# --- full sequence ---- --- best 1 domain ---- --- domain number estimation ---- # target name accession query name accession E-value score bias E-value score bias exp reg clu ov env dom rep inc description of target #------------------- ---------- -------------------- ---------- --------- ------ ----- --------- ------ ----- --- --- --- --- --- --- --- --- --------------------- VID27_N PF17748.1 ETN97098.1 - 0.071 13.0 0.1 0.071 13.0 0.1 2.1 1 1 1 2 2 2 0 VID27 N-terminal region ATS PF15445.6 ETN97098.1 - 0.17 11.2 8.6 0.2 11.0 8.6 1.1 1 0 0 1 1 1 0 acidic terminal segments, variant surface antigen of PfEMP1 PPR PF01535.20 ETN97099.1 - 1.7e-06 27.9 0.6 0.032 14.5 0.1 2.3 2 0 0 2 2 2 2 PPR repeat PPR_2 PF13041.6 ETN97099.1 - 3.8e-06 27.0 1.0 0.0051 17.0 0.1 2.2 2 0 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 ETN97099.1 - 0.016 15.3 0.1 0.21 11.7 0.1 2.1 2 0 0 2 2 2 0 Pentatricopeptide repeat domain mRNA_stabil PF13929.6 ETN97099.1 - 0.04 12.9 0.2 0.045 12.7 0.2 1.1 1 0 0 1 1 1 0 mRNA stabilisation DUF3636 PF12331.8 ETN97099.1 - 0.13 12.1 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) HEAT PF02985.22 ETN97100.1 - 4.4e-13 48.3 0.5 0.9 10.0 0.0 7.7 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 ETN97100.1 - 4.2e-05 23.6 1.8 4.2e-05 23.6 1.8 6.1 2 1 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETN97100.1 - 5e-05 23.6 0.0 0.0043 17.4 0.0 3.5 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ETN97100.1 - 0.001 19.5 0.0 23 5.6 0.0 4.6 3 1 1 4 4 4 0 HEAT-like repeat Ank_3 PF13606.6 ETN97100.1 - 0.0091 16.4 0.1 0.13 12.9 0.0 3.1 3 0 0 3 3 2 1 Ankyrin repeat Vps54 PF07928.12 ETN97100.1 - 0.025 15.0 0.1 0.094 13.1 0.1 2.0 1 0 0 1 1 1 0 Vps54-like protein N_Asn_amidohyd PF14736.6 ETN97100.1 - 0.054 12.6 4.0 1.5 7.9 0.3 3.5 3 1 1 4 4 4 0 Protein N-terminal asparagine amidohydrolase Ank_2 PF12796.7 ETN97100.1 - 0.071 13.7 0.1 0.73 10.5 0.0 2.8 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETN97100.1 - 0.11 13.1 0.2 1.2 9.8 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) DUF627 PF04781.12 ETN97100.1 - 0.11 12.5 1.3 8.5 6.4 0.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF627) BAG PF02179.16 ETN97100.1 - 2.2 8.8 7.7 2.2 8.7 0.1 4.3 4 0 0 4 4 4 0 BAG domain DUF5071 PF16804.5 ETN97100.1 - 2.5 8.4 9.2 2 8.7 2.0 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF5071) UBX PF00789.20 ETN97102.1 - 1.3e-08 34.9 0.2 2.5e-08 34.0 0.0 1.6 2 0 0 2 2 2 1 UBX domain GA PF01468.17 ETN97102.1 - 0.064 13.5 4.2 0.14 12.5 4.1 1.7 1 1 0 1 1 1 0 GA module WD40 PF00400.32 ETN97103.1 - 3.9e-63 207.9 21.1 4.9e-11 43.0 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97103.1 - 3.6e-25 88.1 3.3 0.00057 20.1 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN97103.1 - 2.5e-14 53.0 0.8 0.034 13.1 0.0 6.7 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN97103.1 - 2e-08 34.0 8.4 6.5 6.8 0.1 7.4 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETN97103.1 - 9.1e-08 31.8 3.7 0.12 11.7 0.0 4.2 1 1 4 5 5 5 5 WD40-like domain Cytochrom_D1 PF02239.16 ETN97103.1 - 2e-07 29.9 2.4 0.0002 20.0 0.3 3.0 2 1 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETN97103.1 - 5.2e-05 22.1 4.9 1.9 7.0 0.1 4.5 2 2 3 5 5 5 3 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETN97103.1 - 0.0019 17.0 0.1 3.1 6.5 0.0 3.6 3 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region NHL PF01436.21 ETN97103.1 - 0.0036 17.3 0.8 0.15 12.1 0.1 2.8 3 0 0 3 3 3 1 NHL repeat DUF5570 PF17731.1 ETN97103.1 - 0.0047 17.0 0.7 14 5.8 0.0 4.0 2 1 2 4 4 4 0 Family of unknown function (DUF5570) Flo11 PF10182.9 ETN97103.1 - 0.019 15.1 0.0 5.4 7.1 0.0 2.5 2 0 0 2 2 2 0 Flo11 domain HARP PF07443.13 ETN97103.1 - 0.04 13.5 0.0 0.18 11.4 0.0 2.2 2 0 0 2 2 2 0 HepA-related protein (HARP) nos_propeller PF18764.1 ETN97103.1 - 0.075 12.9 0.0 1 9.3 0.0 2.8 3 1 1 4 4 4 0 Nitrous oxide reductase propeller repeat tRNA-synt_1c PF00749.21 ETN97104.1 - 4.5e-28 98.0 0.0 8.7e-28 97.1 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ETN97104.1 - 6.3e-25 88.0 0.3 1.2e-24 87.1 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), anti-codon binding domain DUF3564 PF12087.8 ETN97105.1 - 0.1 12.6 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3564) WD40 PF00400.32 ETN97106.1 - 2.2e-33 113.7 30.6 4.1e-07 30.6 0.7 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETN97106.1 - 2.8e-09 36.2 9.2 0.0011 17.7 0.9 5.2 2 2 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97106.1 - 3e-09 37.0 1.6 0.34 11.2 0.0 5.3 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain IGR PF09597.10 ETN97107.1 - 0.06 13.5 4.0 1.2 9.3 0.7 2.6 2 1 0 2 2 2 0 IGR protein motif REV1_C PF16727.5 ETN97107.1 - 0.14 12.6 1.8 9.3 6.7 0.2 2.2 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Coq4 PF05019.13 ETN97107.1 - 0.14 11.5 0.9 10 5.4 0.1 2.1 2 0 0 2 2 2 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 Spo7 PF03907.13 ETN97108.1 - 0.0068 15.9 0.7 0.042 13.3 0.1 2.0 2 0 0 2 2 2 1 Spo7-like protein ETRAMP PF09716.10 ETN97108.1 - 4.4 7.4 9.5 9.6 6.4 9.5 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DDE_Tnp_IS1595 PF12762.7 ETN97110.1 - 1.3e-14 54.5 0.8 3.4e-13 49.9 0.8 2.3 1 1 0 1 1 1 1 ISXO2-like transposase domain HSDR_N_2 PF13588.6 ETN97110.1 - 0.023 14.7 1.6 0.045 13.7 0.4 2.1 2 1 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) BRCT PF00533.26 ETN97110.1 - 0.066 13.6 2.6 0.071 13.5 0.2 2.3 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain Adenosine_kin PF04008.14 ETN97111.1 - 0.036 13.9 0.1 0.047 13.5 0.1 1.2 1 0 0 1 1 1 0 Adenosine specific kinase GTP_EFTU PF00009.27 ETN97113.1 - 0.0017 18.0 0.0 0.0026 17.3 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MYCBPAP PF14646.6 ETN97113.1 - 0.0038 16.2 0.4 0.0047 15.9 0.4 1.1 1 0 0 1 1 1 1 MYCBP-associated protein family Lin-8 PF03353.15 ETN97113.1 - 0.094 12.3 2.2 0.12 12.0 2.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Apt1 PF10351.9 ETN97113.1 - 0.18 10.6 9.7 0.18 10.6 9.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF755 PF05501.11 ETN97113.1 - 2.2 8.6 28.8 0.35 11.1 22.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF3446 PF11928.8 ETN97113.1 - 4.3 7.7 21.2 0.86 9.9 17.0 1.9 1 1 1 2 2 2 0 Early growth response N-terminal domain DUF1754 PF08555.10 ETN97113.1 - 7.8 7.4 17.4 2.7 8.8 0.8 2.5 2 1 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Mito_carr PF00153.27 ETN97115.1 - 0.02 14.8 0.0 0.054 13.4 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial carrier protein Ndc1_Nup PF09531.10 ETN97115.1 - 0.056 12.1 0.0 0.075 11.7 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ZZ PF00569.17 ETN97116.1 - 0.0015 18.3 0.9 0.0032 17.3 0.9 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type PI_PP_C PF18365.1 ETN97116.1 - 0.011 15.7 1.4 0.19 11.7 0.0 3.2 3 1 0 3 3 3 0 Phosphoinositide phosphatase C-terminal domain SecA_DEAD PF07517.14 ETN97116.1 - 0.012 15.0 0.6 0.097 11.9 0.0 2.8 2 1 0 2 2 2 0 SecA DEAD-like domain PX PF00787.24 ETN97116.1 - 0.039 13.9 0.2 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 PX domain DUF3783 PF12646.7 ETN97116.1 - 0.11 12.4 0.6 7.9 6.5 0.0 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF3783) DUF3829 PF12889.7 ETN97116.1 - 0.34 10.3 12.1 0.18 11.2 1.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3829) UpxZ PF06603.11 ETN97116.1 - 0.6 10.4 4.6 3 8.2 0.0 3.4 3 1 1 4 4 4 0 UpxZ family of transcription anti-terminator antagonists DUF2536 PF10750.9 ETN97116.1 - 0.92 9.5 4.3 0.38 10.7 0.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2536) Lge1 PF11488.8 ETN97116.1 - 1.3 9.2 6.9 2.1 8.6 1.2 3.0 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 PhoU PF01895.19 ETN97116.1 - 6.2 7.4 9.8 5.5 7.5 0.4 4.2 3 1 1 4 4 4 0 PhoU domain WD40 PF00400.32 ETN97117.1 - 4.7e-27 93.7 2.8 4.6e-10 39.9 0.1 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97117.1 - 1.3e-08 35.1 0.1 0.0093 16.2 0.0 2.9 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97117.1 - 9.3e-07 28.5 1.1 1.6e-06 27.7 1.1 1.4 1 1 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETN97117.1 - 7.3e-06 25.2 0.2 0.29 10.0 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETN97117.1 - 7.7e-05 21.4 0.0 9.3e-05 21.1 0.0 1.1 1 0 0 1 1 1 1 Cytochrome D1 heme domain eIF2A PF08662.11 ETN97117.1 - 0.0002 21.3 0.1 0.00071 19.5 0.1 1.7 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETN97117.1 - 0.0017 18.2 2.5 0.66 10.0 0.0 3.5 3 1 0 3 3 3 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETN97117.1 - 0.0028 16.8 0.1 0.0031 16.6 0.1 1.0 1 0 0 1 1 1 1 Coatomer WD associated region POLO_box PF00659.18 ETN97117.1 - 0.077 13.2 0.1 0.4 10.9 0.0 2.1 2 1 0 2 2 2 0 POLO box duplicated region Proteasome_A_N PF10584.9 ETN97117.1 - 0.26 11.0 0.4 24 4.7 0.0 3.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature TFIIA PF03153.13 ETN97118.1 - 0.02 14.9 47.5 0.022 14.7 47.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NACHT PF05729.12 ETN97120.1 - 0.0015 18.5 1.2 0.19 11.6 0.0 2.5 3 0 0 3 3 3 2 NACHT domain FliG_M PF14841.6 ETN97120.1 - 0.029 14.6 0.3 4.5 7.6 0.0 2.2 2 0 0 2 2 2 0 FliG middle domain Zeta_toxin PF06414.12 ETN97120.1 - 0.084 12.1 0.1 0.87 8.8 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin Peptidase_S9 PF00326.21 ETN97121.1 - 5.9e-34 117.4 0.1 7.2e-34 117.1 0.1 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ETN97121.1 - 0.0067 15.7 0.0 0.0094 15.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Esterase PF00756.20 ETN97121.1 - 0.0099 15.5 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Putative esterase BAAT_C PF08840.11 ETN97121.1 - 0.029 14.3 0.0 0.038 13.9 0.0 1.2 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal DLH PF01738.18 ETN97121.1 - 0.076 12.5 0.2 0.1 12.1 0.2 1.1 1 0 0 1 1 1 0 Dienelactone hydrolase family DUF4746 PF15928.5 ETN97123.1 - 0.14 11.6 2.1 0.18 11.2 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pro-rich_19 PF15455.6 ETN97123.1 - 0.79 8.8 7.0 4.6 6.3 0.2 2.0 1 1 1 2 2 2 0 Proline-rich 19 NST1 PF13945.6 ETN97123.1 - 1.6 8.8 15.7 2.6 8.1 15.7 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Macoilin PF09726.9 ETN97123.1 - 2.3 6.6 11.8 2.6 6.5 11.8 1.1 1 0 0 1 1 1 0 Macoilin family FSA_C PF10479.9 ETN97123.1 - 3.6 5.6 14.4 4.3 5.4 14.4 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus GREB1 PF15782.5 ETN97123.1 - 6.5 3.7 11.8 7.6 3.5 11.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Actin PF00022.19 ETN97124.1 - 2.1e-13 49.6 0.0 2.2e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Actin TPR_2 PF07719.17 ETN97127.1 - 0.011 15.8 7.5 0.12 12.5 0.1 4.2 5 0 0 5 5 5 0 Tetratricopeptide repeat SAG PF04092.13 ETN97127.1 - 0.034 14.9 0.4 0.11 13.3 0.1 2.0 2 0 0 2 2 2 0 SRS domain TPR_8 PF13181.6 ETN97127.1 - 0.14 12.5 0.8 0.59 10.5 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN97127.1 - 0.15 12.2 0.2 0.37 10.9 0.2 1.6 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 ETN97127.1 - 0.22 11.4 4.2 1.3 9.0 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97127.1 - 0.23 11.7 4.3 10 6.5 0.1 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.32 ETN97129.1 - 1.1e-13 51.4 1.0 1.6e-05 25.6 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN97129.1 - 2.1e-05 23.4 0.0 0.027 13.1 0.0 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97129.1 - 0.00052 20.2 0.0 0.91 9.9 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97129.1 - 0.00069 19.0 0.1 0.14 11.5 0.0 2.3 1 1 1 2 2 2 2 WD40-like domain SBP56 PF05694.11 ETN97129.1 - 0.1 11.4 0.0 1.3 7.8 0.0 2.0 2 0 0 2 2 2 0 56kDa selenium binding protein (SBP56) DASH_Dam1 PF08653.10 ETN97131.1 - 0.018 14.8 1.0 0.032 14.0 0.3 1.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 EPO_TPO PF00758.18 ETN97131.1 - 0.024 14.7 1.2 0.033 14.2 1.2 1.1 1 0 0 1 1 1 0 Erythropoietin/thrombopoietin DUF1387 PF07139.11 ETN97132.1 - 0.92 9.2 18.7 1.1 9.0 18.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Mitofilin PF09731.9 ETN97132.1 - 8.8 5.0 15.5 10 4.8 15.5 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein WD40 PF00400.32 ETN97134.1 - 4.1e-10 40.1 8.3 1.2e-08 35.5 3.1 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETN97134.1 - 4.5e-05 22.9 0.9 6.1e-05 22.5 0.9 1.2 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETN97134.1 - 6.9e-05 21.7 0.4 8.2e-05 21.4 0.4 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97134.1 - 0.0097 16.2 0.0 0.012 15.9 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain BLF1 PF17752.1 ETN97134.1 - 0.016 14.5 0.5 0.018 14.4 0.5 1.1 1 0 0 1 1 1 0 Burkholderia lethal factor 1 DUF1943 PF09172.11 ETN97135.1 - 0.53 9.5 5.8 0.12 11.6 2.4 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF1943) DUF5024 PF16427.5 ETN97136.1 - 0.019 15.3 0.2 0.045 14.1 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5024) Sfi1 PF08457.10 ETN97137.1 - 0.057 12.0 0.4 0.09 11.3 0.4 1.2 1 0 0 1 1 1 0 Sfi1 spindle body protein Spindle_Spc25 PF08234.12 ETN97137.1 - 0.085 13.1 1.7 8.3 6.7 0.2 2.9 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 COX5A PF02284.16 ETN97138.1 - 0.00037 20.5 0.5 0.00047 20.1 0.5 1.4 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Syntaxin_2 PF14523.6 ETN97138.1 - 0.018 15.4 7.6 0.12 12.8 7.6 2.0 1 1 0 1 1 1 0 Syntaxin-like protein Fib_alpha PF08702.10 ETN97138.1 - 0.1 12.8 6.3 0.052 13.7 2.0 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family WD40 PF00400.32 ETN97140.1 - 2.6e-24 85.0 1.9 3e-11 43.7 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Pentapeptide PF00805.22 ETN97140.1 - 8.7e-07 28.5 0.1 2.3e-06 27.1 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) ANAPC4_WD40 PF12894.7 ETN97140.1 - 2.7e-06 27.6 0.0 0.00026 21.2 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide_4 PF13599.6 ETN97140.1 - 8.5e-05 22.6 0.0 0.00026 21.1 0.0 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Ge1_WD40 PF16529.5 ETN97140.1 - 0.00037 19.6 0.0 0.48 9.3 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide_3 PF13576.6 ETN97140.1 - 0.0023 18.1 0.2 0.0059 16.7 0.2 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF3472 PF11958.8 ETN97143.1 - 0.23 11.9 6.0 0.28 11.6 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3472) MgsA_C PF12002.8 ETN97143.1 - 1.7 8.6 7.7 2 8.3 7.7 1.1 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal WD40 PF00400.32 ETN97144.1 - 7.8e-12 45.5 2.6 0.00054 20.7 0.2 3.7 3 2 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97144.1 - 0.0029 17.9 0.0 2.9 8.3 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETN97144.1 - 0.04 14.0 0.2 0.099 12.7 0.1 1.7 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ETN97144.1 - 0.094 11.3 0.2 0.8 8.3 0.1 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Kdo PF06293.14 ETN97146.1 - 0.00013 21.4 0.3 0.00022 20.6 0.1 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family HA1 PF18239.1 ETN97146.1 - 0.077 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Hemagglutinin I RNase_H PF00075.24 ETN97148.1 - 6.2e-06 26.4 1.2 0.013 15.7 0.1 2.5 2 1 1 3 3 3 2 RNase H VasL PF12486.8 ETN97148.1 - 0.037 13.9 0.1 0.053 13.4 0.1 1.2 1 0 0 1 1 1 0 Type VI secretion system, EvfB, or VasL zf-C2HE PF16278.5 ETN97149.1 - 0.0022 18.4 1.7 0.0058 17.0 1.7 1.7 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger PRESAN PF09687.10 ETN97149.1 - 0.017 15.7 2.9 0.017 15.7 2.9 2.0 1 1 1 2 2 2 0 Plasmodium RESA N-terminal DUF16 PF01519.16 ETN97149.1 - 0.045 14.2 1.5 0.079 13.5 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF2452 PF10504.9 ETN97149.1 - 0.11 12.0 1.4 0.2 11.1 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) BLOC1_2 PF10046.9 ETN97149.1 - 0.12 12.6 5.2 0.2 12.0 5.2 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YlbD_coat PF14071.6 ETN97149.1 - 0.15 12.3 2.2 0.27 11.5 2.2 1.4 1 0 0 1 1 1 0 Putative coat protein Tubulin PF00091.25 ETN97151.1 - 1e-23 84.6 4.6 2e-11 44.5 1.5 3.0 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain DUF1700 PF08006.11 ETN97152.1 - 0.02 14.4 4.1 0.033 13.7 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) SAM_KSR1 PF13543.6 ETN97154.1 - 0.00011 22.3 3.6 0.031 14.4 0.1 2.8 2 1 1 3 3 3 2 SAM like domain present in kinase suppressor RAS 1 DIL PF01843.19 ETN97154.1 - 0.00078 19.7 0.6 1.3 9.4 0.0 3.3 3 0 0 3 3 3 1 DIL domain HHH_5 PF14520.6 ETN97154.1 - 0.001 19.6 0.1 0.081 13.5 0.0 2.7 2 0 0 2 2 2 1 Helix-hairpin-helix domain HhH-GPD PF00730.25 ETN97154.1 - 0.015 15.7 0.1 0.54 10.7 0.0 2.9 3 0 0 3 3 3 0 HhH-GPD superfamily base excision DNA repair protein SAM_1 PF00536.30 ETN97154.1 - 0.033 14.6 0.1 0.73 10.3 0.0 2.5 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF1757 PF08560.10 ETN97154.1 - 0.14 12.2 0.1 2.8 8.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1757) DUF3944 PF13099.6 ETN97154.1 - 0.16 11.8 0.6 0.55 10.1 0.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) DUF5393 PF17371.2 ETN97154.1 - 0.2 9.8 0.0 0.25 9.4 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5393) Atx10homo_assoc PF09759.9 ETN97154.1 - 0.86 9.7 6.5 1.6 8.8 0.9 3.4 2 1 1 3 3 3 0 Spinocerebellar ataxia type 10 protein domain Slx4 PF09494.10 ETN97154.1 - 0.88 9.6 6.0 7.5 6.6 0.1 3.5 3 1 0 3 3 3 0 Slx4 endonuclease AIG1 PF04548.16 ETN97155.1 - 2e-10 40.4 0.6 2e-10 40.4 0.6 2.3 2 1 0 2 2 2 1 AIG1 family Septin PF00735.18 ETN97155.1 - 6.8e-10 38.7 0.1 1.4e-09 37.7 0.1 1.4 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ETN97155.1 - 2.7e-09 37.1 0.1 9.9e-09 35.3 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_23 PF13476.6 ETN97155.1 - 9.2e-06 26.3 1.5 0.00074 20.1 0.0 2.6 1 1 1 2 2 2 1 AAA domain Dynamin_N PF00350.23 ETN97155.1 - 4.4e-05 23.6 5.3 0.066 13.3 0.0 3.6 3 1 0 3 3 3 2 Dynamin family T2SSE PF00437.20 ETN97155.1 - 7.6e-05 21.9 0.3 0.0002 20.5 0.0 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ETN97155.1 - 0.0003 20.7 0.0 0.0011 18.9 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase GTP_EFTU PF00009.27 ETN97155.1 - 0.00059 19.4 0.0 0.0016 18.0 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 ETN97155.1 - 0.00068 20.2 0.1 0.0051 17.3 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETN97155.1 - 0.00079 19.0 0.0 0.0019 17.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 ETN97155.1 - 0.00081 19.2 0.1 0.047 13.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETN97155.1 - 0.00092 19.5 0.1 0.0034 17.6 0.0 2.0 2 0 0 2 2 1 1 AAA domain AAA_19 PF13245.6 ETN97155.1 - 0.0012 19.2 0.1 0.013 15.8 0.0 2.4 2 1 0 3 3 3 1 AAA domain NACHT PF05729.12 ETN97155.1 - 0.0037 17.2 0.2 0.011 15.6 0.0 1.9 2 0 0 2 2 1 1 NACHT domain PHD PF00628.29 ETN97155.1 - 0.0037 17.1 0.8 0.008 16.1 0.8 1.4 1 0 0 1 1 1 1 PHD-finger AAA_28 PF13521.6 ETN97155.1 - 0.0064 16.8 0.1 1.6 9.0 0.0 2.4 2 0 0 2 2 2 1 AAA domain Roc PF08477.13 ETN97155.1 - 0.007 16.6 0.1 0.052 13.8 0.0 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 ETN97155.1 - 0.011 15.4 0.0 0.034 13.9 0.0 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FtsK_SpoIIIE PF01580.18 ETN97155.1 - 0.011 15.0 0.0 0.023 14.0 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family SRP54 PF00448.22 ETN97155.1 - 0.012 15.3 1.2 0.21 11.2 0.0 2.8 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_16 PF13191.6 ETN97155.1 - 0.013 15.9 0.0 0.037 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ETN97155.1 - 0.013 15.2 0.0 0.04 13.7 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain ResIII PF04851.15 ETN97155.1 - 0.018 15.0 0.4 0.018 15.0 0.4 3.0 2 2 0 2 2 2 0 Type III restriction enzyme, res subunit FeoB_N PF02421.18 ETN97155.1 - 0.024 14.2 0.1 1.9 8.0 0.0 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B ATPase_2 PF01637.18 ETN97155.1 - 0.025 14.5 1.7 0.36 10.7 0.1 2.4 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea TrwB_AAD_bind PF10412.9 ETN97155.1 - 0.041 12.8 0.0 0.072 12.0 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain Sigma54_activat PF00158.26 ETN97155.1 - 0.053 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 ETN97155.1 - 0.072 12.8 0.0 0.2 11.3 0.0 1.7 2 0 0 2 2 2 0 AAA domain NB-ARC PF00931.22 ETN97155.1 - 0.074 12.2 0.8 0.85 8.8 0.0 2.6 3 0 0 3 3 3 0 NB-ARC domain PhoH PF02562.16 ETN97155.1 - 0.077 12.4 0.2 0.22 10.9 0.0 1.8 2 0 0 2 2 1 0 PhoH-like protein PspA_IM30 PF04012.12 ETN97155.1 - 0.078 12.5 3.2 0.14 11.7 3.2 1.3 1 0 0 1 1 1 0 PspA/IM30 family cobW PF02492.19 ETN97155.1 - 0.087 12.4 0.3 0.34 10.5 0.1 2.1 2 1 1 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ETN97155.1 - 0.1 13.0 0.1 0.49 10.8 0.0 2.2 2 0 0 2 2 2 0 RNA helicase DUF87 PF01935.17 ETN97155.1 - 0.21 11.6 4.7 1.6 8.8 0.0 3.0 2 1 1 3 3 3 0 Helicase HerA, central domain KASH_CCD PF14662.6 ETN97155.1 - 0.23 11.3 7.0 0.3 10.9 6.1 1.7 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH ATP_bind_1 PF03029.17 ETN97155.1 - 0.38 10.5 2.2 1.3 8.7 0.0 2.7 3 1 1 4 4 3 0 Conserved hypothetical ATP binding protein CbiA PF01656.23 ETN97155.1 - 1.2 9.2 4.3 38 4.3 4.3 3.0 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain DUF1216 PF06746.11 ETN97155.1 - 4.2 7.4 11.1 0.27 11.2 3.3 3.0 2 1 2 4 4 3 0 Protein of unknown function (DUF1216) DUF3450 PF11932.8 ETN97155.1 - 5.2 6.3 8.2 4.5 6.5 3.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Laminin_II PF06009.12 ETN97156.1 - 0.0023 18.0 12.9 0.0023 18.0 12.9 3.1 1 1 2 3 3 3 1 Laminin Domain II UPF0242 PF06785.11 ETN97156.1 - 0.0085 16.2 29.7 0.0085 16.2 29.7 3.0 1 1 2 3 3 3 1 Uncharacterised protein family (UPF0242) N-terminus ING PF12998.7 ETN97156.1 - 0.023 15.2 17.6 0.023 15.2 17.6 3.2 1 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding ATG16 PF08614.11 ETN97156.1 - 0.047 13.9 49.8 0.028 14.7 25.8 2.2 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 ETN97156.1 - 0.079 12.8 61.8 0.043 13.6 41.5 2.6 1 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH HOOK PF05622.12 ETN97156.1 - 0.33 9.1 59.4 0.07 11.3 33.2 2.2 1 1 1 2 2 2 0 HOOK protein ZapB PF06005.12 ETN97156.1 - 0.35 11.3 69.9 1.2 9.6 16.0 4.5 2 1 1 3 3 2 0 Cell division protein ZapB Fib_alpha PF08702.10 ETN97156.1 - 0.39 10.9 49.5 2.7 8.2 19.9 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 ETN97156.1 - 0.61 10.6 61.8 5.2 7.6 17.5 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region CALCOCO1 PF07888.11 ETN97156.1 - 1.8 7.3 53.1 9.2 5.0 53.1 2.0 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF3450 PF11932.8 ETN97156.1 - 2.7 7.2 48.9 0.055 12.8 17.9 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 ETN97156.1 - 3.4 7.7 57.5 2.6 8.1 21.3 3.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 ETN97156.1 - 4.4 5.8 46.5 5.7 5.5 46.5 1.1 1 0 0 1 1 1 0 AAA domain DUF4407 PF14362.6 ETN97156.1 - 5.8 6.2 38.9 0.53 9.6 18.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 ETN97156.1 - 6.8 6.8 63.9 0.17 12.0 22.3 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding YabA PF06156.13 ETN97156.1 - 8.2 7.1 49.5 30 5.3 8.9 3.5 1 1 2 3 3 3 0 Initiation control protein YabA Golgin_A5 PF09787.9 ETN97156.1 - 9.1 5.6 59.7 23 4.3 20.4 2.5 1 1 1 2 2 2 0 Golgin subfamily A member 5 SIX1_SD PF16878.5 ETN97158.1 - 2.8 8.5 8.0 24 5.5 0.1 3.3 2 1 1 3 3 3 0 Transcriptional regulator, SIX1, N-terminal SD domain 5_3_exonuc PF01367.20 ETN97159.1 - 0.015 15.9 2.9 0.015 15.9 2.9 2.8 2 1 1 3 3 3 0 5'-3' exonuclease, C-terminal SAM fold AAA_23 PF13476.6 ETN97159.1 - 0.027 15.0 12.0 0.056 13.9 0.1 2.1 1 1 0 2 2 2 0 AAA domain Laminin_II PF06009.12 ETN97159.1 - 0.3 11.1 25.6 0.33 10.9 3.7 3.1 2 1 1 3 3 3 0 Laminin Domain II Nup88 PF10168.9 ETN97159.1 - 0.31 8.8 19.3 0.012 13.5 11.9 1.8 2 0 0 2 2 2 0 Nuclear pore component DUF2205 PF10224.9 ETN97159.1 - 0.33 11.0 11.2 0.51 10.4 1.1 3.4 3 0 0 3 3 3 0 Short coiled-coil protein DUF16 PF01519.16 ETN97159.1 - 0.44 11.1 22.9 0.53 10.8 5.4 3.4 2 1 1 3 3 3 0 Protein of unknown function DUF16 Vps54_N PF10475.9 ETN97159.1 - 0.69 9.2 10.4 0.15 11.3 0.3 2.9 2 1 1 3 3 3 0 Vacuolar-sorting protein 54, of GARP complex DUF1664 PF07889.12 ETN97159.1 - 1.7 8.7 19.4 0.32 11.0 1.2 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) CorA PF01544.18 ETN97159.1 - 3.4 6.9 12.2 6.5 6.0 6.9 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein COG2 PF06148.11 ETN97159.1 - 8 6.6 15.7 0.25 11.4 1.5 3.3 3 1 0 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 SKA1 PF07160.12 ETN97159.1 - 9.2 6.0 19.3 0.44 10.4 11.4 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 GHL13 PF14883.6 ETN97160.1 - 0.055 12.5 3.2 0.044 12.8 1.8 1.5 1 1 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 Imm74 PF15603.6 ETN97160.1 - 0.093 12.9 4.0 1.6 8.9 1.4 2.5 1 1 1 2 2 2 0 Immunity protein 74 UPF0160 PF03690.13 ETN97160.1 - 0.094 12.3 3.9 0.11 12.1 3.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0160) Terminase_4 PF05119.12 ETN97160.1 - 0.13 12.7 3.6 0.076 13.5 1.4 1.8 2 0 0 2 2 2 0 Phage terminase, small subunit Osmo_CC PF08946.10 ETN97160.1 - 0.39 11.0 8.9 2.2 8.6 8.9 2.4 1 1 0 1 1 1 0 Osmosensory transporter coiled coil DUF745 PF05335.13 ETN97160.1 - 0.63 9.7 9.9 0.17 11.6 3.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Sec34 PF04136.15 ETN97160.1 - 2 8.3 15.5 0.079 12.8 3.8 2.2 1 1 1 2 2 2 0 Sec34-like family Occludin_ELL PF07303.13 ETN97160.1 - 2.4 8.9 11.5 9.9 7.0 10.0 2.2 1 1 1 2 2 2 0 Occludin homology domain Fib_alpha PF08702.10 ETN97160.1 - 3.9 7.6 18.2 10 6.3 18.2 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 ETN97160.1 - 7.1 6.1 11.3 9.1 5.7 11.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Rap_GAP PF02145.15 ETN97162.1 - 0.0041 16.7 0.2 0.0046 16.5 0.2 1.1 1 0 0 1 1 1 1 Rap/ran-GAP DUF3298 PF11738.8 ETN97162.1 - 0.2 12.7 1.1 2.6 9.2 1.1 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3298) SecA_DEAD PF07517.14 ETN97163.1 - 2.7e-10 40.0 0.0 7.1e-10 38.6 0.0 1.7 1 0 0 1 1 1 1 SecA DEAD-like domain Helicase_C PF00271.31 ETN97163.1 - 3.4e-05 24.1 0.0 0.00021 21.6 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF563 PF04577.14 ETN97164.1 - 0.0039 17.3 0.1 0.0043 17.2 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) TPM_phosphatase PF04536.14 ETN97164.1 - 0.042 14.0 0.0 0.047 13.9 0.0 1.2 1 0 0 1 1 1 0 TPM domain DRY_EERY PF09750.9 ETN97165.1 - 0.06 13.6 4.6 0.079 13.2 4.6 1.2 1 0 0 1 1 1 0 Alternative splicing regulator GLTP PF08718.11 ETN97165.1 - 0.16 12.3 2.4 0.21 11.9 2.4 1.1 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) ASL_C PF08328.11 ETN97165.1 - 0.31 11.2 9.0 0.17 12.0 6.3 1.7 1 1 1 2 2 2 0 Adenylosuccinate lyase C-terminal DUF2911 PF11138.8 ETN97165.1 - 0.56 10.1 4.2 1 9.2 4.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2911) Exonuc_VII_L PF02601.15 ETN97165.1 - 0.68 9.4 4.9 0.77 9.3 4.9 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Transposase_22 PF02994.14 ETN97165.1 - 5 7.4 9.5 3.6 7.8 7.6 1.7 1 1 1 2 2 2 0 L1 transposable element RBD-like domain TH1 PF04858.13 ETN97167.1 - 2e-05 23.5 6.3 0.00056 18.7 6.3 2.4 1 1 0 1 1 1 1 TH1 protein Kelch_2 PF07646.15 ETN97171.1 - 2.1e-06 27.5 0.1 0.0054 16.7 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETN97171.1 - 9e-06 25.6 0.0 0.007 16.4 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN97171.1 - 0.00018 21.7 0.4 0.12 12.7 0.3 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETN97171.1 - 0.0011 19.1 0.0 0.016 15.5 0.0 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN97171.1 - 0.0036 16.9 0.2 0.009 15.6 0.1 1.8 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETN97171.1 - 0.096 12.7 0.3 0.32 11.0 0.2 1.8 2 0 0 2 2 2 0 Kelch motif DUF4715 PF15835.5 ETN97172.1 - 2.4 8.2 9.5 5.9 7.0 2.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4715) Sec20 PF03908.13 ETN97172.1 - 4.5 7.3 12.2 0.9 9.5 0.7 3.2 1 1 2 3 3 3 0 Sec20 IFT57 PF10498.9 ETN97173.1 - 0.00083 18.4 9.5 0.0014 17.7 8.8 1.7 1 1 0 1 1 1 1 Intra-flagellar transport protein 57 MscS_porin PF12795.7 ETN97173.1 - 0.0013 18.3 8.8 0.003 17.1 8.9 1.6 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain Cytochrom_B562 PF07361.11 ETN97173.1 - 0.0014 19.3 27.1 0.61 10.8 7.9 4.0 2 2 1 3 3 3 3 Cytochrome b562 DUF1664 PF07889.12 ETN97173.1 - 0.0058 16.7 15.7 0.021 14.8 7.2 3.0 4 0 0 4 4 2 1 Protein of unknown function (DUF1664) Lectin_N PF03954.14 ETN97173.1 - 0.035 13.9 3.1 0.066 13.0 1.8 2.1 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain LMBR1 PF04791.16 ETN97173.1 - 0.038 12.9 6.1 0.061 12.2 6.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Fusion_gly PF00523.18 ETN97173.1 - 0.19 9.9 5.0 0.43 8.8 1.8 2.2 1 1 1 2 2 2 0 Fusion glycoprotein F0 ING PF12998.7 ETN97173.1 - 0.22 12.1 8.7 0.36 11.4 1.0 2.8 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding BST2 PF16716.5 ETN97173.1 - 0.41 11.3 13.1 3.9 8.1 1.0 3.3 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 AAA_13 PF13166.6 ETN97173.1 - 0.55 8.8 16.2 1.1 7.8 16.2 1.4 1 0 0 1 1 1 0 AAA domain TRPM_tetra PF16519.5 ETN97173.1 - 0.59 10.3 10.9 1.5 9.0 0.1 4.5 5 0 0 5 5 5 0 Tetramerisation domain of TRPM DUF1993 PF09351.10 ETN97173.1 - 0.65 10.1 7.1 1.5 9.0 7.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1993) COG2 PF06148.11 ETN97173.1 - 0.9 9.6 11.4 2.5 8.2 8.6 3.2 3 1 0 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 V_ATPase_I PF01496.19 ETN97173.1 - 1.7 6.5 7.9 2.5 5.9 7.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Baculo_PEP_C PF04513.12 ETN97173.1 - 1.8 8.6 10.1 2.7 8.0 6.1 3.1 3 1 0 3 3 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Exonuc_VII_L PF02601.15 ETN97173.1 - 1.9 8.0 8.3 1.2 8.7 6.2 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit Spc7 PF08317.11 ETN97173.1 - 1.9 7.3 24.8 0.41 9.5 20.4 2.0 2 1 0 2 2 2 0 Spc7 kinetochore protein Vps53_N PF04100.12 ETN97173.1 - 2.4 7.0 14.1 0.64 8.9 7.6 2.5 3 1 1 4 4 4 0 Vps53-like, N-terminal DUF4407 PF14362.6 ETN97173.1 - 2.9 7.2 15.0 0.31 10.4 10.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Sulfatase_C PF14707.6 ETN97173.1 - 2.9 8.7 4.6 3.7 8.3 1.3 2.5 1 1 1 2 2 2 0 C-terminal region of aryl-sulfatase DUF4140 PF13600.6 ETN97173.1 - 3.3 8.2 11.1 6.7 7.2 6.5 3.0 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF948 PF06103.11 ETN97173.1 - 3.6 7.9 12.1 12 6.3 6.0 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Spore_III_AB PF09548.10 ETN97173.1 - 4 7.5 7.8 1.5 8.9 4.4 2.1 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Snapin_Pallidin PF14712.6 ETN97173.1 - 4.1 7.9 13.7 7.5 7.1 8.4 2.9 1 1 1 2 2 2 0 Snapin/Pallidin HrpB7 PF09486.10 ETN97173.1 - 4.1 7.8 16.2 0.36 11.2 6.4 2.7 3 0 0 3 3 2 0 Bacterial type III secretion protein (HrpB7) Atg14 PF10186.9 ETN97173.1 - 4.5 6.3 13.6 0.67 9.0 1.7 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 ETN97173.1 - 5.2 6.2 15.4 6 6.0 5.9 2.3 1 1 1 2 2 2 0 TMPIT-like protein Seryl_tRNA_N PF02403.22 ETN97173.1 - 6.3 7.1 23.8 2.3 8.5 13.3 3.3 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.12 ETN97173.1 - 7.3 6.6 23.5 1.5 8.9 11.5 3.8 3 1 1 4 4 4 0 Laminin Domain II KxDL PF10241.9 ETN97173.1 - 8.3 6.8 7.1 9.5 6.6 2.1 3.3 1 1 2 3 3 3 0 Uncharacterized conserved protein RNA_pol_Rpb5_C PF01191.19 ETN97176.1 - 0.011 15.6 0.9 0.011 15.6 0.9 1.6 2 0 0 2 2 2 0 RNA polymerase Rpb5, C-terminal domain TPR_12 PF13424.6 ETN97177.1 - 7.3e-23 80.7 5.3 2.5e-15 56.5 1.5 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97177.1 - 9.1e-14 50.8 0.6 4.9e-05 23.1 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97177.1 - 7.1e-13 47.6 4.1 0.00064 19.6 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97177.1 - 3.4e-12 45.6 12.9 4.3e-06 26.3 1.4 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97177.1 - 2e-06 27.5 9.7 0.18 12.0 0.6 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97177.1 - 3.9e-06 26.7 11.3 0.0021 18.1 0.7 3.6 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN97177.1 - 5.8e-05 22.6 0.0 6.9e-05 22.4 0.0 1.0 1 0 0 1 1 1 1 MalT-like TPR region TPR_17 PF13431.6 ETN97177.1 - 0.01 16.1 1.0 25 5.5 0.1 3.6 3 2 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97177.1 - 0.011 15.5 4.1 0.62 9.8 0.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETN97177.1 - 0.013 16.2 0.1 2.1 9.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETN97177.1 - 0.17 11.9 6.2 2.1 8.4 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETN97177.1 - 0.18 11.9 4.2 6.6 6.9 0.2 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 ETN97177.1 - 0.34 11.0 3.9 0.66 10.1 0.1 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 ETN97177.1 - 3.6 8.0 6.5 6.8 7.2 0.2 3.4 4 0 0 4 4 3 0 PPR repeat AAA PF00004.29 ETN97178.1 - 1e-07 32.5 0.0 0.00027 21.4 0.0 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETN97178.1 - 2.1e-07 30.6 0.1 0.0092 15.5 0.0 2.8 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETN97178.1 - 1e-06 28.8 0.0 0.0011 18.9 0.0 2.8 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETN97178.1 - 2.3e-06 27.9 0.3 0.0089 16.3 0.0 3.2 3 0 0 3 3 3 2 AAA domain ABC_tran PF00005.27 ETN97178.1 - 0.00056 20.4 0.4 0.004 17.7 0.2 2.6 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ETN97178.1 - 0.00067 19.6 0.0 0.0019 18.2 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ETN97178.1 - 0.0011 19.4 0.1 0.24 11.8 0.0 2.9 2 1 0 2 2 2 1 AAA ATPase domain DUF815 PF05673.13 ETN97178.1 - 0.0013 18.0 0.0 0.0047 16.1 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) MCM PF00493.23 ETN97178.1 - 0.0016 17.6 1.0 0.035 13.2 0.1 2.8 3 0 0 3 3 3 1 MCM P-loop domain AAA_8 PF12780.7 ETN97178.1 - 0.0016 17.8 0.2 0.0058 16.0 0.0 2.0 1 1 1 2 2 2 1 P-loop containing dynein motor region D4 TsaE PF02367.17 ETN97178.1 - 0.0045 17.0 1.6 0.14 12.1 0.0 3.1 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ETN97178.1 - 0.0063 16.4 0.6 1.5 8.7 0.2 3.0 2 0 0 2 2 2 1 NACHT domain AAA_19 PF13245.6 ETN97178.1 - 0.0068 16.7 0.1 5.2 7.4 0.0 2.5 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ETN97178.1 - 0.036 13.8 0.0 0.77 9.4 0.0 2.8 2 0 0 2 2 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 ETN97178.1 - 0.053 13.6 0.0 1.3 9.2 0.0 2.7 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETN97178.1 - 0.058 13.8 0.3 2.2 8.7 0.1 3.2 2 1 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 ETN97178.1 - 0.071 12.8 0.0 0.61 9.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETN97178.1 - 0.1 11.9 0.1 14 5.0 0.0 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI PduV-EutP PF10662.9 ETN97178.1 - 0.11 12.3 0.1 0.11 12.3 0.1 2.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation WBP-1 PF11669.8 ETN97178.1 - 0.22 12.2 2.0 0.63 10.7 0.3 2.5 2 0 0 2 2 2 0 WW domain-binding protein 1 PI3_PI4_kinase PF00454.27 ETN97180.1 - 6.3e-26 91.7 0.7 8.9e-26 91.2 0.7 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ETN97180.1 - 1.7e-13 50.1 0.1 3.1e-13 49.3 0.1 1.5 1 0 0 1 1 1 1 FATC domain Chordopox_A35R PF05989.12 ETN97180.1 - 0.0053 16.7 1.5 0.01 15.7 1.5 1.5 1 1 0 1 1 1 1 Chordopoxvirus A35R protein PAS_6 PF08348.11 ETN97180.1 - 0.077 12.9 1.4 0.22 11.4 0.0 2.4 3 1 1 4 4 4 0 YheO-like PAS domain CHAT PF12770.7 ETN97181.1 - 8e-08 32.0 0.1 1.5e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 CHAT domain Ndc1_Nup PF09531.10 ETN97181.1 - 0.0055 15.5 6.3 0.0076 15.0 6.3 1.2 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Apt1 PF10351.9 ETN97181.1 - 0.044 12.6 14.1 0.073 11.9 14.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ETN97181.1 - 1.8 8.4 21.0 4 7.3 21.0 1.5 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 ETN97181.1 - 3 6.3 16.5 5 5.6 16.5 1.2 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 ETN97181.1 - 3.7 6.6 19.9 6.2 5.9 19.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein Zip PF02535.22 ETN97181.1 - 4 6.5 6.5 6.9 5.8 6.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETN97181.1 - 8 5.1 14.7 13 4.4 14.7 1.2 1 0 0 1 1 1 0 Presenilin Arabino_trans_N PF17689.1 ETN97183.1 - 0.12 12.6 0.0 0.14 12.3 0.0 1.1 1 0 0 1 1 1 0 Arabinosyltransferase concanavalin like domain Microvir_H PF04687.12 ETN97184.1 - 0.57 9.5 3.6 0.57 9.5 3.6 1.0 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) Gal4_dimer PF03902.13 ETN97184.1 - 0.65 10.2 3.3 2.6 8.3 0.4 2.3 2 0 0 2 2 2 0 Gal4-like dimerisation domain Elf1 PF05129.13 ETN97185.1 - 0.0097 15.9 0.0 0.023 14.7 0.0 1.7 1 0 0 1 1 1 1 Transcription elongation factor Elf1 like DUF4058 PF13267.6 ETN97185.1 - 0.19 11.1 4.0 0.25 10.7 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) Secretin_N_2 PF07655.13 ETN97186.1 - 1.4 9.5 9.1 0.25 11.9 4.3 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain TPR_12 PF13424.6 ETN97188.1 - 1.5e-30 105.2 3.6 1.4e-17 63.7 0.3 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97188.1 - 2.4e-26 90.4 25.4 2.2e-11 43.1 1.8 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97188.1 - 8.8e-26 89.0 7.3 9.5e-10 38.0 0.2 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97188.1 - 2.5e-21 74.0 17.8 5.3e-09 35.5 0.5 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97188.1 - 7e-21 72.7 4.4 5.9e-08 32.2 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97188.1 - 7.7e-19 66.3 19.1 4.4e-08 32.7 0.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97188.1 - 9.7e-13 48.5 0.0 1.8e-05 25.3 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97188.1 - 6.3e-12 45.0 14.9 0.0028 17.9 3.3 4.2 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97188.1 - 2.3e-09 37.3 2.7 0.077 13.7 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97188.1 - 1.4e-08 34.3 32.1 0.00072 19.2 0.4 6.5 4 3 2 7 7 7 3 TPR repeat TPR_14 PF13428.6 ETN97188.1 - 8e-08 32.5 0.0 0.079 13.8 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETN97188.1 - 2.9e-07 29.8 0.7 0.033 13.7 0.0 3.5 3 0 0 3 3 3 2 SHNi-TPR ANAPC3 PF12895.7 ETN97188.1 - 1.1e-05 25.6 8.3 0.0029 17.8 1.1 2.7 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETN97188.1 - 2.4e-05 24.2 13.2 0.011 15.8 0.7 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97188.1 - 2.5e-05 24.7 2.5 0.048 14.2 0.7 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_5 PF12688.7 ETN97188.1 - 0.00012 22.3 0.1 0.0077 16.5 0.0 2.2 1 1 1 2 2 2 1 Tetratrico peptide repeat SNAP PF14938.6 ETN97188.1 - 0.00025 20.6 6.8 0.0076 15.7 2.6 2.5 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP DUF627 PF04781.12 ETN97188.1 - 0.00066 19.7 1.4 1.7 8.7 0.0 3.0 3 1 0 3 3 3 2 Protein of unknown function (DUF627) DUF2225 PF09986.9 ETN97188.1 - 0.011 15.5 6.1 0.058 13.1 1.4 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETN97188.1 - 0.011 15.5 13.9 0.045 13.6 0.3 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) MIT PF04212.18 ETN97188.1 - 0.012 15.6 16.6 0.015 15.3 1.0 4.0 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain ATP-synt_E_2 PF08112.11 ETN97188.1 - 0.014 15.6 1.1 12 6.3 0.0 3.2 3 0 0 3 3 3 0 ATP synthase epsilon subunit HTH_Bact PF18768.1 ETN97188.1 - 0.016 14.8 6.1 4 7.1 0.1 4.0 4 0 0 4 4 4 0 Helix-turn-helix bacterial domain BAR_3 PF16746.5 ETN97188.1 - 0.058 13.1 0.6 0.091 12.5 0.6 1.4 1 1 0 1 1 1 0 BAR domain of APPL family PPR PF01535.20 ETN97188.1 - 0.074 13.3 1.1 43 4.7 0.1 3.3 3 0 0 3 3 3 0 PPR repeat OEP PF02321.18 ETN97188.1 - 0.075 12.8 3.2 0.52 10.1 0.6 2.3 2 1 0 2 2 2 0 Outer membrane efflux protein YflT PF11181.8 ETN97188.1 - 0.15 12.5 2.1 0.36 11.4 1.6 1.9 1 1 1 2 2 2 0 Heat induced stress protein YflT SPO22 PF08631.10 ETN97188.1 - 0.24 10.9 3.3 0.55 9.7 0.3 2.3 2 1 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like RPN7 PF10602.9 ETN97188.1 - 0.32 10.7 3.8 0.4 10.4 1.8 2.2 1 1 1 2 2 2 0 26S proteasome subunit RPN7 DUF4992 PF16383.5 ETN97188.1 - 0.86 9.1 7.2 13 5.3 0.1 3.0 1 1 2 3 3 3 0 Domain of unknown function NSF PF02071.20 ETN97188.1 - 0.96 10.5 8.0 11 7.3 0.1 4.4 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat DUF1515 PF07439.11 ETN97189.1 - 0.00033 20.6 2.3 0.00033 20.6 2.3 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF1515) YabA PF06156.13 ETN97189.1 - 0.039 14.6 10.6 0.47 11.1 5.1 2.9 1 1 1 3 3 3 0 Initiation control protein YabA FliT PF05400.13 ETN97189.1 - 0.18 12.6 6.7 0.53 11.1 0.0 3.2 1 1 1 3 3 3 0 Flagellar protein FliT YL1 PF05764.13 ETN97189.1 - 0.91 9.6 19.1 2 8.5 19.0 1.7 1 1 0 1 1 1 0 YL1 nuclear protein DHR10 PF18595.1 ETN97189.1 - 0.93 9.6 12.3 0.98 9.5 2.3 3.2 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain ZapB PF06005.12 ETN97189.1 - 2.3 8.7 15.7 0.68 10.4 0.1 3.4 1 1 2 3 3 3 0 Cell division protein ZapB DUF2203 PF09969.9 ETN97189.1 - 2.8 8.7 9.4 8.3 7.2 0.0 2.9 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) ADIP PF11559.8 ETN97189.1 - 4.9 7.2 17.0 0.22 11.6 9.7 2.3 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding IBN_N PF03810.19 ETN97190.1 - 0.0019 18.1 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain Kinetochor_Ybp2 PF08568.10 ETN97190.1 - 0.014 14.0 0.0 0.017 13.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family, YAP/Alf4/glomulin Mis12 PF05859.12 ETN97190.1 - 0.061 13.4 0.0 0.079 13.0 0.0 1.2 1 0 0 1 1 1 0 Mis12 protein HEAT PF02985.22 ETN97191.1 - 2.9e-06 27.1 4.0 0.022 15.0 0.3 3.6 3 1 0 3 3 3 2 HEAT repeat IFRD PF05004.13 ETN97191.1 - 0.00041 19.5 1.0 0.00074 18.7 0.9 1.4 1 1 0 1 1 1 1 Interferon-related developmental regulator (IFRD) Vac14_Fab1_bd PF12755.7 ETN97191.1 - 0.0013 19.3 0.2 0.029 15.0 0.0 2.6 1 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ETN97191.1 - 0.0014 17.3 2.2 0.011 14.4 2.1 2.3 1 1 0 1 1 1 1 Adaptin N terminal region MMS19_C PF12460.8 ETN97191.1 - 0.0069 15.6 2.4 0.012 14.8 0.1 2.1 1 1 1 3 3 3 2 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 ETN97191.1 - 0.0079 16.3 2.0 0.066 13.3 1.1 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Sec7_N PF12783.7 ETN97191.1 - 0.012 15.5 4.8 2.2 8.2 4.8 2.1 1 1 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Xpo1 PF08389.12 ETN97191.1 - 0.013 15.5 0.8 0.11 12.6 0.2 2.2 1 1 1 2 2 2 0 Exportin 1-like protein HEAT_2 PF13646.6 ETN97191.1 - 0.039 14.3 1.2 0.19 12.1 1.1 2.1 1 1 1 2 2 2 0 HEAT repeats HEAT_EZ PF13513.6 ETN97191.1 - 0.17 12.5 3.3 3.1 8.4 0.3 3.3 2 1 2 4 4 4 0 HEAT-like repeat HEAT PF02985.22 ETN97192.1 - 0.00074 19.6 0.7 0.52 10.7 0.2 3.1 3 0 0 3 3 3 2 HEAT repeat IFRD PF05004.13 ETN97192.1 - 0.00098 18.3 0.2 0.0024 17.0 0.2 1.6 2 0 0 2 2 2 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 ETN97192.1 - 0.0086 16.6 0.0 0.04 14.4 0.0 2.1 2 0 0 2 2 2 1 HEAT-like repeat V-ATPase_H_C PF11698.8 ETN97192.1 - 0.075 13.1 0.2 0.72 10.0 0.0 2.2 2 1 0 2 2 2 0 V-ATPase subunit H BP28CT PF08146.12 ETN97193.1 - 0.00013 21.8 0.3 2.1 8.1 0.1 3.3 2 1 0 2 2 2 2 BP28CT (NUC211) domain Importin_rep_6 PF18829.1 ETN97193.1 - 0.11 12.6 0.8 0.5 10.5 0.8 2.1 1 0 0 1 1 1 0 Importin repeat 6 Cation_ATPase_C PF00689.21 ETN97194.1 - 2.4e-11 43.7 0.4 3.4e-11 43.2 0.4 1.2 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus DUF4549 PF15082.6 ETN97194.1 - 0.063 13.1 0.0 0.097 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) Macoilin PF09726.9 ETN97195.1 - 0.56 8.7 5.0 0.44 9.0 5.0 1.0 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETN97195.1 - 1.3 7.3 8.5 1.2 7.4 8.5 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETN97195.1 - 1.8 7.3 4.6 1.6 7.4 4.6 1.0 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETN97195.1 - 7.5 7.6 8.2 11 7.1 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Integrase_H2C2 PF17921.1 ETN97197.1 - 1.6e-12 47.4 0.1 2.7e-12 46.6 0.1 1.4 1 0 0 1 1 1 1 Integrase zinc binding domain rve PF00665.26 ETN97197.1 - 9.7e-07 29.0 0.0 1.7e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain zf-H2C2 PF09337.10 ETN97197.1 - 0.045 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 H2C2 zinc finger EnY2 PF10163.9 ETN97199.1 - 0.33 11.4 4.6 4.2 7.8 0.9 2.2 2 0 0 2 2 2 0 Transcription factor e(y)2 RNase_J_C PF17770.1 ETN97199.1 - 1.1 10.3 8.6 0.76 10.9 0.7 2.2 1 1 1 2 2 2 0 Ribonuclease J C-terminal domain O-antigen_lig PF13425.6 ETN97202.1 - 4.8 5.9 5.9 5.1 5.8 5.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CoA_binding_3 PF13727.6 ETN97203.1 - 0.19 11.7 0.0 0.28 11.2 0.0 1.2 1 0 0 1 1 1 0 CoA-binding domain O-antigen_lig PF13425.6 ETN97203.1 - 4.3 6.0 9.1 6.7 5.4 9.1 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CDC50 PF03381.15 ETN97205.1 - 9.7e-22 77.8 3.5 7.8e-14 51.9 0.6 2.1 2 0 0 2 2 2 2 LEM3 (ligand-effect modulator 3) family / CDC50 family PalH PF08733.10 ETN97205.1 - 0.021 13.8 5.3 0.025 13.6 5.3 1.1 1 0 0 1 1 1 0 PalH/RIM21 Phage_T4_gp19 PF06841.12 ETN97205.1 - 0.14 12.0 0.4 0.23 11.3 0.4 1.4 1 0 0 1 1 1 0 T4-like virus tail tube protein gp19 Serinc PF03348.15 ETN97209.1 - 2.8e-12 46.3 1.1 3.1e-12 46.2 1.1 1.2 1 0 0 1 1 1 1 Serine incorporator (Serinc) IBR PF01485.21 ETN97210.1 - 0.77 10.0 5.9 0.2 11.9 1.5 2.1 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain WD40 PF00400.32 ETN97212.1 - 9e-58 190.9 16.3 1.3e-11 44.8 0.3 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97212.1 - 2.1e-22 79.2 0.4 0.0009 19.5 0.0 5.4 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN97212.1 - 5.4e-12 45.3 0.1 0.043 12.8 0.0 5.5 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETN97212.1 - 7.6e-12 45.5 0.3 1.3e-05 25.2 0.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETN97212.1 - 3.3e-09 36.5 3.0 0.001 18.5 0.3 3.2 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETN97212.1 - 1.8e-07 30.2 5.8 1.3 7.6 0.0 4.9 1 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETN97212.1 - 1.1e-05 25.2 5.9 2.6 8.1 0.1 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETN97212.1 - 2e-05 23.8 1.6 0.0022 17.1 1.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region DUF5570 PF17731.1 ETN97212.1 - 4.1e-05 23.7 0.9 16 5.6 0.1 4.8 2 1 2 4 4 4 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETN97212.1 - 4.1e-05 22.3 0.8 0.11 11.0 0.0 2.7 1 1 3 4 4 4 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETN97212.1 - 0.00014 20.7 5.5 0.14 10.9 1.5 3.5 1 1 2 3 3 3 3 Nup133 N terminal like DUF4999 PF16390.5 ETN97212.1 - 0.00032 20.9 3.9 16 5.8 0.1 4.4 4 0 0 4 4 4 0 Domain of unknown function SGL PF08450.12 ETN97212.1 - 0.00063 19.4 0.3 0.0071 15.9 0.3 2.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region VID27 PF08553.10 ETN97212.1 - 0.001 18.2 0.2 0.89 8.5 0.0 3.1 1 1 2 3 3 3 1 VID27 C-terminal WD40-like domain DUF5449 PF17528.2 ETN97212.1 - 0.0033 17.2 1.2 3.5 7.4 0.1 3.8 1 1 3 4 4 4 1 Family of unknown function (DUF5449) SBD PF17882.1 ETN97212.1 - 0.0038 17.1 1.0 1e+02 2.7 0.0 4.1 1 1 0 2 2 2 0 OAA-family lectin sugar binding domain DUF4221 PF13970.6 ETN97212.1 - 0.0055 16.3 1.2 0.18 11.3 0.1 3.0 1 1 2 4 4 4 1 Domain of unknown function (DUF4221) PQQ PF01011.21 ETN97212.1 - 0.006 16.5 0.0 16 5.6 0.0 3.7 3 0 0 3 3 3 0 PQQ enzyme repeat NHL PF01436.21 ETN97212.1 - 0.017 15.1 0.2 39 4.5 0.0 3.8 3 0 0 3 3 3 0 NHL repeat IKI3 PF04762.12 ETN97212.1 - 0.058 11.4 0.5 0.65 7.9 0.2 2.0 1 1 1 2 2 2 0 IKI3 family TraK PF06586.11 ETN97212.1 - 0.074 12.7 0.9 2.6 7.7 0.0 2.8 2 1 1 3 3 3 0 TraK protein Surfac_D-trimer PF09006.11 ETN97212.1 - 0.19 11.6 0.3 2.3 8.2 0.1 2.8 2 1 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation PS_Dcarbxylase PF02666.15 ETN97212.1 - 0.46 10.0 4.1 9.9 5.6 0.2 3.8 1 1 2 3 3 3 0 Phosphatidylserine decarboxylase HEAT_2 PF13646.6 ETN97213.1 - 0.0068 16.8 0.0 0.0095 16.3 0.0 1.2 1 0 0 1 1 1 1 HEAT repeats DUF3944 PF13099.6 ETN97213.1 - 0.027 14.3 0.7 0.07 13.0 0.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) OrfB_IS605 PF01385.19 ETN97213.1 - 0.087 13.1 0.2 0.19 12.0 0.2 1.6 2 0 0 2 2 2 0 Probable transposase ORF6N PF10543.9 ETN97213.1 - 0.29 11.3 1.5 6.2 7.1 0.1 2.4 2 1 0 2 2 2 0 ORF6N domain U-box PF04564.15 ETN97214.1 - 6.5e-13 48.7 0.1 1.3e-12 47.7 0.1 1.5 1 1 0 1 1 1 1 U-box domain NPR3 PF03666.13 ETN97215.1 - 1 8.1 10.2 1 8.1 10.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ureide_permease PF07168.11 ETN97215.1 - 2.1 7.0 2.9 2.3 6.9 2.9 1.1 1 0 0 1 1 1 0 Ureide permease Ada3 PF10198.9 ETN97218.1 - 3.8e-05 23.9 0.1 6.1e-05 23.2 0.1 1.3 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 TPR_19 PF14559.6 ETN97220.1 - 0.0028 18.1 0.0 0.0051 17.3 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97220.1 - 0.017 15.2 0.0 0.035 14.2 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97220.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETN97220.1 - 0.18 12.0 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97221.1 - 0.0026 18.2 0.0 0.0055 17.2 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97221.1 - 0.018 15.1 0.0 0.036 14.2 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97221.1 - 0.11 12.4 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETN97221.1 - 0.18 12.0 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat HEAT_2 PF13646.6 ETN97222.1 - 5.1e-05 23.6 0.0 0.9 10.0 0.0 3.9 2 1 2 4 4 4 1 HEAT repeats HEAT_EZ PF13513.6 ETN97222.1 - 0.00012 22.5 0.1 8.8 7.0 0.0 4.4 5 0 0 5 5 5 2 HEAT-like repeat HEAT PF02985.22 ETN97222.1 - 0.00086 19.4 2.7 6.2 7.4 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat Urb2 PF10441.9 ETN97222.1 - 0.0064 16.4 0.2 0.83 9.6 0.0 3.1 1 1 1 2 2 2 1 Urb2/Npa2 family MMS19_N PF14500.6 ETN97222.1 - 0.012 15.2 3.8 0.07 12.7 0.3 2.8 1 1 1 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Pneumo_matrix PF03393.16 ETN97222.1 - 0.038 13.2 0.7 0.055 12.7 0.7 1.2 1 0 0 1 1 1 0 Pneumovirus matrix protein TAN PF11640.8 ETN97222.1 - 0.099 12.8 4.7 0.85 9.7 0.1 3.2 1 1 1 2 2 2 0 Telomere-length maintenance and DNA damage repair KicB PF03882.14 ETN97222.1 - 0.13 12.4 3.9 41 4.4 0.1 4.1 2 2 3 5 5 5 0 MukF winged-helix domain Sigma54_activ_2 PF14532.6 ETN97222.1 - 0.14 12.3 3.7 3.2 7.8 0.2 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_lid_7 PF17867.1 ETN97222.1 - 0.47 10.7 3.1 2 8.6 0.1 3.4 3 1 1 4 4 4 0 Midasin AAA lid domain NACHT PF05729.12 ETN97225.1 - 7e-06 26.1 0.0 1.2e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain THDPS_N PF14790.6 ETN97225.1 - 0.027 14.3 1.7 0.22 11.3 0.2 2.3 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal ALMT PF11744.8 ETN97225.1 - 4.6 6.0 7.4 6.2 5.5 7.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter VWA PF00092.28 ETN97226.1 - 0.019 15.2 0.0 1.6 8.9 0.0 2.7 1 1 0 1 1 1 0 von Willebrand factor type A domain WD40 PF00400.32 ETN97227.1 - 1.7e-19 69.8 16.6 7.9e-08 32.9 3.1 4.1 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97227.1 - 2.8e-08 33.9 0.1 0.016 15.5 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97227.1 - 6.5e-08 31.7 1.0 0.016 13.9 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN97227.1 - 0.011 15.1 0.4 0.53 9.6 0.1 2.2 1 1 1 2 2 2 0 WD40-like domain BLF1 PF17752.1 ETN97227.1 - 0.063 12.6 0.0 0.2 11.0 0.1 1.7 2 0 0 2 2 2 0 Burkholderia lethal factor 1 DUF4221 PF13970.6 ETN97227.1 - 0.14 11.7 3.3 2.3 7.7 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Actin PF00022.19 ETN97229.1 - 3.6e-105 351.9 0.0 2.2e-55 187.9 0.0 2.1 1 1 1 2 2 2 2 Actin DUF3819 PF12842.7 ETN97230.1 - 0.035 14.0 0.1 0.059 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) zf-TRAF PF02176.18 ETN97231.1 - 6.9e-09 36.3 6.2 1.7e-08 35.0 6.2 1.7 1 0 0 1 1 1 1 TRAF-type zinc finger MalF_P2 PF14785.6 ETN97231.1 - 0.014 15.4 3.4 0.019 15.0 3.4 1.2 1 0 0 1 1 1 0 Maltose transport system permease protein MalF P2 domain Uso1_p115_C PF04871.13 ETN97231.1 - 0.061 13.7 10.7 0.12 12.7 10.7 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region NRBF2 PF08961.10 ETN97231.1 - 0.073 12.7 10.4 0.034 13.7 8.2 1.6 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator AAA_11 PF13086.6 ETN97231.1 - 0.19 11.5 6.9 0.19 11.5 6.9 1.1 1 0 0 1 1 1 0 AAA domain Cnn_1N PF07989.11 ETN97231.1 - 1.1 9.5 18.2 0.51 10.5 14.1 2.4 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Rootletin PF15035.6 ETN97231.1 - 1.6 8.7 17.0 2.8 7.9 17.0 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.21 ETN97231.1 - 2 8.6 16.9 0.33 11.1 11.2 2.5 2 1 1 3 3 3 0 bZIP transcription factor ZapB PF06005.12 ETN97231.1 - 3.3 8.2 19.8 1.4 9.4 16.5 2.2 2 1 0 2 2 2 0 Cell division protein ZapB DUF5595 PF18077.1 ETN97231.1 - 4.7 7.4 10.1 2 8.6 7.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF5595) CN_hydrolase PF00795.22 ETN97232.1 - 9e-06 25.2 0.0 1.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase DUF3150 PF11348.8 ETN97234.1 - 0.023 13.9 3.0 0.044 13.0 1.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3150) DUF1133 PF06576.11 ETN97234.1 - 0.051 13.0 2.0 0.064 12.7 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1133) Trp_DMAT PF11991.8 ETN97234.1 - 0.069 12.6 0.6 0.12 11.7 0.2 1.5 1 1 0 1 1 1 0 Tryptophan dimethylallyltransferase FOXP-CC PF16159.5 ETN97234.1 - 0.15 12.7 6.9 2.5 8.8 0.1 2.9 2 1 1 3 3 3 0 FOXP coiled-coil domain EDS1_EP PF18117.1 ETN97234.1 - 0.31 11.5 4.5 0.15 12.5 2.1 1.7 2 0 0 2 2 2 0 Enhanced disease susceptibility 1 protein EP domain Tubulin PF00091.25 ETN97234.1 - 0.43 10.7 5.5 0.6 10.3 5.5 1.2 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain V-ATPase_G PF03179.15 ETN97234.1 - 0.44 11.1 12.7 0.91 10.1 12.7 1.6 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Exonuc_VII_L PF02601.15 ETN97234.1 - 0.53 9.8 8.7 0.7 9.4 8.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Laminin_II PF06009.12 ETN97234.1 - 0.95 9.5 11.4 2.3 8.3 11.4 1.6 1 1 1 2 2 2 0 Laminin Domain II RAP80_UIM PF18282.1 ETN97234.1 - 1.1 9.1 5.5 0.17 11.7 1.4 1.8 2 0 0 2 2 2 0 RAP80 N-terminal ubiquitin interaction motif LMBR1 PF04791.16 ETN97234.1 - 1.1 8.1 7.6 1.3 7.9 7.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein FAD-SLDH PF12318.8 ETN97234.1 - 2.1 8.4 4.5 1.8 8.6 0.8 2.0 1 1 1 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase FAM76 PF16046.5 ETN97234.1 - 4.5 6.6 14.3 1.4 8.2 11.5 1.5 1 1 0 1 1 1 0 FAM76 protein Ly49 PF08391.10 ETN97234.1 - 7.3 7.0 17.3 0.52 10.7 1.1 2.4 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region CBP4 PF07960.11 ETN97234.1 - 8 6.3 11.7 12 5.8 11.7 1.1 1 0 0 1 1 1 0 CBP4 AI-2E_transport PF01594.16 ETN97234.1 - 9.4 5.3 9.1 8.1 5.5 1.9 2.0 1 1 1 2 2 2 0 AI-2E family transporter zf-RanBP PF00641.18 ETN97235.1 - 0.0012 18.1 1.8 0.0012 18.1 1.8 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ETN97235.1 - 0.014 15.4 0.2 0.014 15.4 0.2 2.5 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger Ino80_Iec3 PF14612.6 ETN97235.1 - 0.11 13.1 4.6 0.13 12.9 4.6 1.1 1 0 0 1 1 1 0 IEC3 subunit of the Ino80 complex, chromatin re-modelling UIM PF02809.20 ETN97235.1 - 0.14 12.1 9.0 0.43 10.6 2.9 2.6 2 0 0 2 2 2 0 Ubiquitin interaction motif DZR PF12773.7 ETN97235.1 - 0.18 11.8 6.8 0.2 11.7 1.2 1.9 1 1 1 2 2 2 0 Double zinc ribbon Ribosomal_L37e PF01907.19 ETN97235.1 - 0.37 11.0 3.4 4 7.7 0.3 2.4 2 0 0 2 2 2 0 Ribosomal protein L37e DUF1735 PF08522.10 ETN97235.1 - 0.48 11.0 4.1 0.85 10.2 4.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1735) Menin PF05053.13 ETN97235.1 - 0.56 8.5 9.6 0.58 8.5 9.6 1.1 1 0 0 1 1 1 0 Menin zinc_ribbon_2 PF13240.6 ETN97235.1 - 0.71 9.7 6.5 0.15 11.8 1.5 2.2 2 0 0 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 ETN97235.1 - 1.4 8.5 5.1 42 3.7 0.1 3.5 3 0 0 3 3 3 0 zinc-ribbon domain Mit_ribos_Mrp51 PF11709.8 ETN97236.1 - 0.094 12.3 0.5 0.12 12.0 0.5 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit LAP1C PF05609.12 ETN97237.1 - 2.1 7.4 33.5 3 6.8 33.5 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WD40 PF00400.32 ETN97238.1 - 0.0071 17.2 0.5 0.022 15.6 0.2 1.9 2 1 0 2 2 2 1 WD domain, G-beta repeat PqqD PF05402.12 ETN97239.1 - 0.033 14.5 0.1 0.05 13.9 0.1 1.4 1 0 0 1 1 1 0 Coenzyme PQQ synthesis protein D (PqqD) MCR_alpha_N PF02745.15 ETN97239.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, N-terminal domain PT PF04886.12 ETN97240.1 - 0.00023 20.6 67.6 0.062 12.8 19.1 4.6 1 1 2 3 3 3 1 PT repeat DUF1700 PF08006.11 ETN97241.1 - 0.0033 17.0 0.4 0.0034 16.9 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1700) HEAT_2 PF13646.6 ETN97242.1 - 0.0019 18.6 0.0 0.12 12.8 0.0 2.8 2 1 1 3 3 3 1 HEAT repeats MMS19_C PF12460.8 ETN97242.1 - 0.026 13.7 2.3 0.58 9.2 2.3 2.0 1 1 0 1 1 1 0 RNAPII transcription regulator C-terminal APG6 PF04111.12 ETN97242.1 - 0.038 13.9 1.3 0.39 10.6 0.5 2.2 1 1 1 2 2 2 0 Apg6 BARA domain MMS19_N PF14500.6 ETN97242.1 - 0.06 12.9 0.3 0.38 10.3 0.0 2.0 1 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Syja_N PF02383.18 ETN97242.1 - 0.19 11.0 3.5 0.32 10.3 0.4 2.1 1 1 1 2 2 2 0 SacI homology domain WD40 PF00400.32 ETN97245.1 - 9.7e-12 45.2 4.4 0.00011 22.9 0.1 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN97245.1 - 0.0018 17.0 0.1 0.67 8.5 0.0 2.0 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Ig_6 PF18452.1 ETN97245.1 - 0.063 12.9 0.1 0.12 11.9 0.1 1.4 1 0 0 1 1 1 0 Immunoglobulin domain CTP_transf_like PF01467.26 ETN97246.1 - 1.3e-05 25.5 0.1 3e-05 24.2 0.1 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like DUF3138 PF11336.8 ETN97246.1 - 0.16 10.6 1.1 0.2 10.2 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) SMK-1 PF04802.15 ETN97248.1 - 0.03 14.2 0.5 0.039 13.8 0.5 1.0 1 0 0 1 1 1 0 Component of IIS longevity pathway SMK-1 Kelch_1 PF01344.25 ETN97249.1 - 5.7e-06 25.8 0.7 0.11 12.1 0.3 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETN97249.1 - 0.00081 19.6 4.8 0.16 12.3 0.6 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETN97249.1 - 0.0088 16.0 1.4 0.52 10.4 0.2 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETN97249.1 - 0.017 15.1 3.1 0.034 14.2 0.1 3.1 3 1 0 3 3 3 0 Galactose oxidase, central domain 2-ph_phosp PF04029.14 ETN97249.1 - 0.037 13.2 0.0 0.058 12.6 0.0 1.3 1 0 0 1 1 1 0 2-phosphosulpholactate phosphatase Kelch_5 PF13854.6 ETN97249.1 - 2 8.5 6.0 1.6 8.8 0.2 3.2 4 0 0 4 4 4 0 Kelch motif Mito_carr PF00153.27 ETN97250.1 - 1.4e-19 69.8 0.6 9.3e-13 47.9 0.0 2.0 1 1 1 2 2 2 2 Mitochondrial carrier protein Cas_CT1975 PF09344.10 ETN97251.1 - 0.018 14.5 0.1 0.019 14.5 0.1 1.0 1 0 0 1 1 1 0 CT1975-like protein DUSP PF06337.12 ETN97253.1 - 0.13 12.9 0.5 0.31 11.7 0.5 1.6 1 0 0 1 1 1 0 DUSP domain Cys_rich_FGFR PF00839.17 ETN97253.1 - 0.13 12.4 3.3 1.7 8.8 0.1 3.5 4 0 0 4 4 4 0 Cysteine rich repeat CTK3 PF12243.8 ETN97253.1 - 0.78 9.7 6.4 11 6.1 0.0 3.7 3 1 1 4 4 4 0 CTD kinase subunit gamma CTK3 Kelch_5 PF13854.6 ETN97254.1 - 0.0071 16.3 3.3 0.013 15.5 0.6 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETN97254.1 - 0.12 12.4 0.9 0.94 9.6 0.1 2.8 3 0 0 3 3 3 0 Kelch motif Ras PF00071.22 ETN97255.1 - 3.8e-06 26.6 0.0 6.8e-06 25.8 0.0 1.4 1 1 0 1 1 1 1 Ras family EGF_MSP1_1 PF12946.7 ETN97255.1 - 1.3 9.1 5.1 2.7 8.1 2.9 2.3 2 0 0 2 2 2 0 MSP1 EGF domain 1 Histone PF00125.24 ETN97257.1 - 1.1 9.6 11.5 1.2 9.5 11.5 1.0 1 0 0 1 1 1 0 Core histone H2A/H2B/H3/H4 Connexin PF00029.19 ETN97257.1 - 1.8 8.3 6.1 1.8 8.3 6.1 1.1 1 0 0 1 1 1 0 Connexin WD40 PF00400.32 ETN97259.1 - 2.8e-17 62.8 8.5 2.3e-09 37.7 1.2 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN97259.1 - 9.1e-05 21.3 0.4 0.0019 16.9 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97259.1 - 0.0055 17.0 0.0 0.016 15.5 0.0 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97259.1 - 0.024 14.0 0.1 0.024 14.0 0.1 1.5 2 0 0 2 2 2 0 WD40-like domain CsiD PF08943.10 ETN97260.1 - 0.025 13.7 0.1 0.028 13.5 0.1 1.1 1 0 0 1 1 1 0 CsiD BAAT_C PF08840.11 ETN97260.1 - 0.2 11.6 2.0 0.22 11.4 2.0 1.1 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal Torus PF16131.5 ETN97260.1 - 0.25 12.0 2.7 0.28 11.9 1.2 1.8 1 1 0 1 1 1 0 Torus domain sCache_like PF16736.5 ETN97260.1 - 0.55 10.3 6.7 1.1 9.3 6.8 1.5 1 1 0 1 1 1 0 Single Cache-like Clat_adaptor_s PF01217.20 ETN97261.1 - 0.0097 15.8 0.6 0.014 15.3 0.6 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain Tim44 PF04280.15 ETN97261.1 - 0.048 13.8 0.7 0.061 13.4 0.7 1.3 1 0 0 1 1 1 0 Tim44-like domain DUF2373 PF10180.9 ETN97261.1 - 0.057 13.3 0.5 1.4 8.8 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) CENP-Q PF13094.6 ETN97261.1 - 8.8 6.5 17.2 8.2 6.6 15.3 1.8 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit RAB3GAP2_C PF14656.6 ETN97262.1 - 0.024 12.9 0.1 0.024 12.9 0.1 1.5 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Glyco_hydro_49 PF03718.13 ETN97263.1 - 0.083 12.9 2.6 0.25 11.4 0.2 2.3 2 1 0 2 2 2 0 Glycosyl hydrolase family 49 DUF4558 PF15104.6 ETN97264.1 - 0.085 12.9 2.4 0.13 12.4 0.6 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4558) Suppressor_APC PF11414.8 ETN97265.1 - 0.015 15.3 2.3 0.37 10.9 0.1 2.9 1 1 3 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein SUB1_ProdP9 PF18213.1 ETN97265.1 - 0.04 13.8 2.2 0.061 13.2 2.2 1.3 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 ExsD PF16806.5 ETN97265.1 - 0.045 13.7 2.0 0.055 13.4 2.0 1.1 1 0 0 1 1 1 0 Antiactivator protein ExsD WD-3 PF09765.9 ETN97265.1 - 0.047 13.0 1.6 0.052 12.9 1.6 1.1 1 0 0 1 1 1 0 WD-repeat region DUF5117 PF17148.4 ETN97265.1 - 0.049 13.5 0.8 0.18 11.7 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5117) FemAB PF02388.16 ETN97265.1 - 0.055 12.3 1.8 0.061 12.2 1.8 1.0 1 0 0 1 1 1 0 FemAB family DUF2443 PF10398.9 ETN97265.1 - 0.093 12.8 5.2 1.5 8.9 2.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2443) PCRF PF03462.18 ETN97265.1 - 0.097 12.5 2.2 0.12 12.3 2.2 1.1 1 0 0 1 1 1 0 PCRF domain CENP-R PF06729.12 ETN97265.1 - 0.11 12.4 6.4 0.13 12.2 6.4 1.1 1 0 0 1 1 1 0 Kinetochore component, CENP-R Mlo PF03094.15 ETN97265.1 - 0.11 10.8 0.0 0.11 10.8 0.0 1.9 1 1 0 2 2 2 0 Mlo family BLOC1_2 PF10046.9 ETN97265.1 - 0.2 11.9 6.8 0.17 12.2 5.5 1.6 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FapA PF03961.13 ETN97265.1 - 0.28 9.8 6.1 0.29 9.7 6.1 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin PF02996.17 ETN97265.1 - 0.56 10.1 8.4 4.6 7.2 0.2 2.5 2 1 1 3 3 3 0 Prefoldin subunit Osmo_CC PF08946.10 ETN97265.1 - 3.1 8.1 8.9 6.1 7.2 0.5 2.5 2 1 0 2 2 2 0 Osmosensory transporter coiled coil XhlA PF10779.9 ETN97265.1 - 4.7 7.5 11.5 2 8.7 3.6 2.5 1 1 1 2 2 2 0 Haemolysin XhlA SF3a60_bindingd PF12108.8 ETN97265.1 - 6.3 6.8 6.2 12 5.9 0.1 3.0 3 0 0 3 3 3 0 Splicing factor SF3a60 binding domain DUF2052 PF09747.9 ETN97266.1 - 0.098 12.8 9.2 0.11 12.6 9.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) TFIIF_alpha PF05793.12 ETN97266.1 - 0.17 10.4 15.2 0.2 10.2 15.2 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Tub_N PF16322.5 ETN97266.1 - 0.18 12.2 12.1 0.2 12.0 12.1 1.1 1 0 0 1 1 1 0 Tubby N-terminal FAM176 PF14851.6 ETN97266.1 - 0.21 11.2 7.3 0.24 11.0 7.3 1.2 1 0 0 1 1 1 0 FAM176 family Myc_N PF01056.18 ETN97266.1 - 0.22 11.4 11.6 0.25 11.2 11.6 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Sporozoite_P67 PF05642.11 ETN97266.1 - 0.57 8.2 7.7 0.61 8.1 7.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4746 PF15928.5 ETN97266.1 - 0.77 9.1 11.7 0.81 9.1 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TRAP_alpha PF03896.16 ETN97266.1 - 1.3 8.2 7.3 1.4 8.1 7.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 ETN97266.1 - 1.6 6.9 8.8 1.7 6.8 8.8 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 ETN97266.1 - 3.7 7.8 14.0 5.7 7.2 14.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 ETN97266.1 - 5.2 7.5 8.5 4.1 7.8 7.5 1.4 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RR_TM4-6 PF06459.12 ETN97266.1 - 5.5 6.7 13.2 6.7 6.4 13.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ureide_permease PF07168.11 ETN97266.1 - 7.2 5.3 4.7 7.7 5.2 4.7 1.0 1 0 0 1 1 1 0 Ureide permease RTT107_BRCT_6 PF16771.5 ETN97268.1 - 0.02 15.1 0.4 0.052 13.7 0.4 1.7 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Pkinase PF00069.25 ETN97270.1 - 9e-37 126.9 0.0 1.5e-36 126.2 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN97270.1 - 1.9e-21 76.5 0.0 2.4e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETN97270.1 - 1.6e-06 27.6 0.1 4.7e-06 26.1 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETN97270.1 - 0.003 16.4 0.1 0.0048 15.7 0.1 1.3 1 1 0 1 1 1 1 Fungal protein kinase DUF3112 PF11309.8 ETN97271.1 - 0.0027 17.2 1.3 0.0051 16.3 1.3 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3112) Pkinase PF00069.25 ETN97272.1 - 5.5e-18 65.3 0.0 1.5e-09 37.6 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain NACHT PF05729.12 ETN97274.1 - 7.2e-07 29.3 0.0 8.3e-07 29.1 0.0 1.1 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETN97274.1 - 0.0089 16.6 0.0 0.011 16.3 0.0 1.3 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETN97274.1 - 0.08 13.3 0.8 0.95 9.9 0.8 2.1 1 1 0 1 1 1 0 RNA helicase Cyclase_polyket PF04673.12 ETN97274.1 - 0.091 13.0 0.3 0.11 12.8 0.3 1.2 1 0 0 1 1 1 0 Polyketide synthesis cyclase AAA_5 PF07728.14 ETN97274.1 - 0.1 12.6 0.0 1.5 8.8 0.0 2.0 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF3287 PF11690.8 ETN97276.1 - 0.021 14.5 2.6 0.051 13.3 2.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3287) Spc7 PF08317.11 ETN97277.1 - 0.036 12.9 37.6 0.41 9.5 27.5 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein TMPIT PF07851.13 ETN97277.1 - 0.081 12.2 30.9 0.25 10.6 15.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein Golgin_A5 PF09787.9 ETN97277.1 - 0.14 11.6 36.4 0.29 10.5 23.3 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 APG6_N PF17675.1 ETN97277.1 - 0.22 12.0 35.9 0.33 11.5 2.2 3.0 2 1 1 3 3 3 0 Apg6 coiled-coil region DUF1411 PF07199.11 ETN97277.1 - 0.3 10.7 8.0 0.64 9.7 7.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1411) CENP-F_leu_zip PF10473.9 ETN97277.1 - 0.37 10.8 43.9 0.4 10.7 26.7 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 ETN97277.1 - 0.47 9.9 40.9 0.64 9.4 23.2 2.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF2259 PF10016.9 ETN97277.1 - 1.3 8.9 5.3 1.8 8.4 3.9 1.9 1 1 1 2 2 2 0 Predicted secreted protein (DUF2259) TRAF_BIRC3_bd PF16673.5 ETN97277.1 - 1.8 8.4 16.1 1.4 8.8 1.6 2.8 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain NPV_P10 PF05531.12 ETN97277.1 - 2.5 8.6 22.1 14 6.2 0.9 4.2 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein Fez1 PF06818.15 ETN97277.1 - 2.9 8.3 32.7 2.5e+02 2.0 32.7 2.2 1 1 0 1 1 1 0 Fez1 DUF1525 PF07511.11 ETN97277.1 - 3.4 7.9 12.5 0.19 11.9 2.2 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1525) TPR_MLP1_2 PF07926.12 ETN97277.1 - 4.8 7.3 38.7 0.075 13.1 3.9 3.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 ETN97277.1 - 7.2 6.7 34.6 1.2 9.2 20.7 2.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Cnd1_N PF12922.7 ETN97279.1 - 0.00097 19.0 1.6 0.001 19.0 1.6 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term O_anti_polymase PF01901.16 ETN97279.1 - 0.12 11.7 1.7 0.13 11.5 1.7 1.0 1 0 0 1 1 1 0 Putative O-antigen polymerase SDH_sah PF01972.16 ETN97279.1 - 0.13 11.3 1.5 0.16 11.0 1.5 1.1 1 0 0 1 1 1 0 Serine dehydrogenase proteinase Ycf70 PF17382.2 ETN97279.1 - 0.19 12.1 5.6 0.27 11.7 5.6 1.4 1 0 0 1 1 1 0 Uncharacterized Ycf70-like OATP PF03137.20 ETN97279.1 - 0.26 9.5 2.2 0.29 9.3 2.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2681 PF10883.8 ETN97279.1 - 0.48 10.9 8.8 0.66 10.4 8.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) OAD_gamma PF04277.13 ETN97279.1 - 5.5 7.7 5.8 11 6.6 5.8 1.6 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain WD40 PF00400.32 ETN97280.1 - 4.3e-19 68.5 18.6 1.2e-07 32.2 2.5 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97280.1 - 1.7e-09 37.8 0.2 0.0012 19.1 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97280.1 - 2.1e-07 30.0 0.9 0.066 11.8 0.1 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN97280.1 - 0.00017 21.0 2.3 0.0035 16.7 1.5 2.5 1 1 1 2 2 2 1 WD40-like domain Peptidase_C6 PF00851.18 ETN97280.1 - 0.0026 16.8 2.2 0.0031 16.5 2.2 1.1 1 0 0 1 1 1 1 Helper component proteinase GH101_N PF17995.1 ETN97280.1 - 0.035 13.8 1.4 0.05 13.2 1.4 1.3 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase N-terminal Cys_rich_VLP PF14194.6 ETN97281.1 - 0.047 13.8 0.4 0.1 12.7 0.4 1.6 1 0 0 1 1 1 0 Cysteine-rich VLP zf-TRAF PF02176.18 ETN97283.1 - 0.00066 20.3 4.1 0.00066 20.3 4.1 2.0 2 0 0 2 2 2 1 TRAF-type zinc finger PKcGMP_CC PF16808.5 ETN97283.1 - 0.017 14.9 5.2 0.017 14.9 5.2 3.6 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 ETN97283.1 - 0.038 14.3 16.3 0.53 10.6 3.6 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Geminin PF07412.12 ETN97283.1 - 0.042 13.6 3.8 0.042 13.6 3.8 2.9 2 1 0 2 2 2 0 Geminin TPR_MLP1_2 PF07926.12 ETN97283.1 - 0.046 13.8 17.3 0.94 9.5 5.5 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1192 PF06698.11 ETN97283.1 - 0.054 13.5 7.5 6.4 6.9 2.0 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF1192) Wtap PF17098.5 ETN97283.1 - 0.23 11.4 12.0 10 6.0 12.0 2.3 1 1 0 1 1 1 0 WTAP/Mum2p family Cep57_CLD_2 PF14197.6 ETN97283.1 - 0.53 10.4 12.3 0.54 10.4 5.8 2.6 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Fez1 PF06818.15 ETN97283.1 - 0.88 10.0 18.7 0.83 10.1 12.8 2.6 1 1 1 2 2 2 0 Fez1 YabA PF06156.13 ETN97283.1 - 3.1 8.5 17.2 1.6 9.4 7.0 2.7 1 1 0 2 2 2 0 Initiation control protein YabA FapA PF03961.13 ETN97283.1 - 9.1 4.8 20.5 4.1 5.9 7.7 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A TPR_12 PF13424.6 ETN97284.1 - 5.8e-19 68.2 0.6 1.7e-11 44.2 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97284.1 - 2e-13 49.7 0.1 6.9e-05 22.6 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97284.1 - 7.8e-12 44.4 9.8 0.0011 19.0 1.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97284.1 - 1.5e-11 43.6 6.5 5.2e-06 26.0 0.8 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97284.1 - 1.3e-08 34.3 1.0 0.005 16.8 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97284.1 - 4.4e-08 32.6 4.8 0.0018 18.2 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97284.1 - 0.00055 19.6 3.8 0.17 11.6 0.1 3.5 3 1 1 4 4 4 1 TPR repeat SHNi-TPR PF10516.9 ETN97284.1 - 0.0051 16.2 0.9 3.9 7.0 0.1 3.4 3 0 0 3 3 3 2 SHNi-TPR TPR_3 PF07720.12 ETN97284.1 - 0.0091 16.0 3.1 0.066 13.2 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97284.1 - 0.018 15.7 0.2 3.1 8.7 0.0 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.9 ETN97284.1 - 0.05 13.3 0.9 0.25 11.0 0.0 2.1 1 1 1 2 2 2 0 26S proteasome subunit RPN7 MIT PF04212.18 ETN97284.1 - 0.13 12.4 6.9 4.6 7.4 0.7 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 ETN97285.1 - 1.8e-10 40.9 0.0 6.5e-07 29.5 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97285.1 - 1.8e-07 30.9 0.7 2.8e-06 27.1 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97285.1 - 1.4e-06 28.0 0.0 9.8e-05 22.1 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97285.1 - 9.8e-06 25.3 0.1 0.0025 17.8 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97285.1 - 0.00032 20.4 0.3 0.0024 17.6 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97285.1 - 0.00058 19.7 0.0 0.023 14.7 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97285.1 - 0.2 12.6 0.0 0.35 11.8 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF5531 PF17671.1 ETN97286.1 - 1.2 9.0 5.5 0.73 9.7 4.1 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5531) DUF1330 PF07045.11 ETN97288.1 - 0.14 12.5 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1330) Nup84_Nup100 PF04121.13 ETN97290.1 - 2.4e-34 118.6 26.4 5.5e-17 61.2 10.8 4.3 3 2 0 3 3 3 3 Nuclear pore protein 84 / 107 CbeA_antitoxin PF06154.11 ETN97291.1 - 0.043 14.4 0.1 0.92 10.1 0.0 2.6 1 1 2 3 3 3 0 CbeA_antitoxin, type IV, cytoskeleton bundling-enhancing factor A MMACHC PF16690.5 ETN97291.1 - 0.44 10.2 4.7 0.88 9.2 0.8 2.5 1 1 2 3 3 3 0 Methylmalonic aciduria and homocystinuria type C family CAP_GLY PF01302.25 ETN97293.1 - 0.094 12.7 0.1 0.31 11.1 0.0 1.9 3 0 0 3 3 3 0 CAP-Gly domain Thioredoxin_11 PF18078.1 ETN97294.1 - 0.041 14.0 3.7 2.3 8.3 0.3 2.1 2 0 0 2 2 2 0 Thioredoxin-like SNTX domain DUF3716 PF12511.8 ETN97294.1 - 0.17 11.9 0.6 0.3 11.2 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3716) WD40 PF00400.32 ETN97295.1 - 2.3e-19 69.4 20.6 3.9e-06 27.5 0.1 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN97295.1 - 3.2e-06 26.1 0.4 0.11 11.1 0.0 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97295.1 - 7.8e-06 26.1 0.3 0.39 11.0 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97295.1 - 0.012 14.9 1.1 0.13 11.5 0.7 2.3 1 1 2 3 3 3 0 WD40-like domain DUF4221 PF13970.6 ETN97295.1 - 0.046 13.3 2.2 0.15 11.6 1.3 1.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4221) CAP_GLY PF01302.25 ETN97296.1 - 0.0019 18.2 0.1 0.92 9.6 0.0 2.4 2 0 0 2 2 2 2 CAP-Gly domain CENP-B_dimeris PF09026.10 ETN97296.1 - 0.86 10.0 6.3 2.6 8.5 1.3 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SAP18 PF06487.12 ETN97296.1 - 1.5 9.0 4.6 6.2 7.0 4.6 2.2 1 1 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) RPA43_OB PF17875.1 ETN97296.1 - 6.3 7.4 8.6 1.5 9.4 3.7 2.3 1 1 1 2 2 2 0 RPA43 OB domain in RNA Pol I FG-GAP PF01839.23 ETN97298.1 - 1.5e-13 50.6 2.6 1.5e-06 28.2 0.7 2.3 2 0 0 2 2 2 2 FG-GAP repeat VCBS PF13517.6 ETN97298.1 - 6.1e-07 29.9 3.2 1.8e-06 28.4 2.4 2.0 2 1 0 2 2 2 1 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella Itfg2 PF15907.5 ETN97298.1 - 0.15 11.1 0.1 0.7 8.9 0.1 1.8 1 1 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 RGS PF00615.19 ETN97299.1 - 2.2e-07 31.1 2.2 3.2e-07 30.6 2.2 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain Phosphorylase PF00343.20 ETN97299.1 - 0.02 13.2 0.0 0.025 12.9 0.0 1.1 1 0 0 1 1 1 0 Carbohydrate phosphorylase VPS13 PF16908.5 ETN97301.1 - 0.043 13.6 0.2 0.052 13.3 0.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal HEAT PF02985.22 ETN97302.1 - 4.5e-16 57.6 0.1 0.00018 21.4 0.0 4.6 4 1 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 ETN97302.1 - 1.2e-10 41.7 0.0 4.3e-06 27.0 0.0 2.5 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 ETN97302.1 - 1.2e-08 35.2 0.0 0.27 11.8 0.0 4.1 3 1 1 4 4 4 3 HEAT-like repeat Cnd1 PF12717.7 ETN97302.1 - 1.5e-06 28.4 7.2 0.00075 19.6 2.2 2.7 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 ETN97302.1 - 9.9e-05 21.6 0.5 5.4 6.0 0.0 3.1 1 1 0 2 2 2 1 Interferon-related developmental regulator (IFRD) RTP1_C1 PF10363.9 ETN97302.1 - 0.00028 21.1 0.1 0.0034 17.5 0.0 2.4 1 1 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 ETN97302.1 - 0.00037 19.2 1.2 0.00063 18.4 0.5 1.5 1 1 0 1 1 1 1 Adaptin N terminal region TIP120 PF08623.10 ETN97302.1 - 0.00037 20.3 0.5 0.18 11.6 0.0 2.6 1 1 1 2 2 2 2 TATA-binding protein interacting (TIP20) DUF5105 PF17118.5 ETN97302.1 - 0.00045 20.0 1.5 2.8 7.7 0.0 3.7 1 1 3 4 4 4 1 Domain of unknown function (DUF5105) ThylakoidFormat PF11264.8 ETN97302.1 - 0.00098 18.9 1.6 0.19 11.4 0.1 2.7 1 1 2 3 3 3 1 Thylakoid formation protein XkdW PF09636.10 ETN97302.1 - 0.0027 17.8 2.8 0.36 11.0 0.0 3.1 2 1 1 3 3 3 1 XkdW protein Vac14_Fab1_bd PF12755.7 ETN97302.1 - 0.0029 18.2 0.2 0.76 10.4 0.0 2.8 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region Mu-like_Pro PF10123.9 ETN97302.1 - 0.004 16.8 0.5 0.0092 15.6 0.2 1.5 1 1 1 2 2 2 1 Mu-like prophage I protein DrsE PF02635.15 ETN97302.1 - 0.0054 17.1 1.9 0.048 14.0 1.4 2.3 1 1 1 2 2 2 1 DsrE/DsrF-like family MMS19_N PF14500.6 ETN97302.1 - 0.007 16.0 0.4 0.068 12.7 0.4 2.2 1 1 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II CART PF06373.11 ETN97302.1 - 0.0087 16.2 1.0 1.8 8.8 0.1 3.0 3 0 0 3 3 2 1 Cocaine and amphetamine regulated transcript protein (CART) HBB PF06777.11 ETN97302.1 - 0.012 15.3 2.5 1.4 8.6 0.3 2.5 2 1 1 3 3 3 0 Helical and beta-bridge domain Spore_III_AB PF09548.10 ETN97302.1 - 0.013 15.7 1.9 0.017 15.3 1.0 1.7 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Med23 PF11573.8 ETN97302.1 - 0.014 13.1 4.3 0.089 10.4 0.2 2.7 1 1 2 3 3 3 0 Mediator complex subunit 23 HEAT_PBS PF03130.16 ETN97302.1 - 0.016 15.8 0.0 1.2e+02 3.8 0.0 4.5 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat UME PF08064.13 ETN97302.1 - 0.016 15.1 0.1 9.1 6.3 0.0 2.9 1 1 1 2 2 2 0 UME (NUC010) domain Ku_PK_bind PF08785.11 ETN97302.1 - 0.056 13.6 2.8 4.2 7.6 0.1 3.2 1 1 1 2 2 2 0 Ku C terminal domain like DUF4428 PF14471.6 ETN97302.1 - 0.063 13.2 4.1 1.5 8.8 0.5 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) Prp18 PF02840.15 ETN97302.1 - 0.075 13.1 1.5 3.2 7.8 0.1 2.7 1 1 1 2 2 2 0 Prp18 domain DUF445 PF04286.12 ETN97302.1 - 0.077 12.8 3.4 0.16 11.7 3.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Activator-TraM PF11657.8 ETN97302.1 - 0.1 12.4 1.0 0.31 10.9 0.0 2.1 2 1 0 2 2 2 0 Transcriptional activator TraM Spore_Cse60 PF10957.8 ETN97302.1 - 0.16 12.0 5.5 1.1 9.4 0.2 3.6 3 1 0 3 3 3 0 Sporulation protein Cse60 PRIMA1 PF16101.5 ETN97303.1 - 0.14 12.2 0.4 0.16 12.0 0.4 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 V_ATPase_I PF01496.19 ETN97304.1 - 0.018 13.0 9.0 0.02 12.9 9.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PMC2NT PF08066.12 ETN97304.1 - 0.024 15.3 6.3 0.026 15.2 1.3 2.4 2 0 0 2 2 2 0 PMC2NT (NUC016) domain LMBR1 PF04791.16 ETN97304.1 - 0.049 12.6 6.9 0.057 12.3 6.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Nup54 PF13874.6 ETN97304.1 - 0.099 12.7 11.2 0.073 13.2 3.6 2.6 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 YkyA PF10368.9 ETN97304.1 - 0.14 11.8 28.9 0.21 11.3 28.9 1.2 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein RmuC PF02646.16 ETN97304.1 - 0.18 10.9 17.4 0.25 10.5 4.3 2.2 1 1 0 2 2 2 0 RmuC family Prominin PF05478.11 ETN97304.1 - 0.19 9.7 11.7 0.24 9.3 11.7 1.1 1 0 0 1 1 1 0 Prominin DUF4407 PF14362.6 ETN97304.1 - 0.2 11.0 10.9 0.25 10.7 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SLATT_4 PF18186.1 ETN97304.1 - 0.27 10.8 8.4 4.3 7.0 0.2 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 MCPsignal PF00015.21 ETN97304.1 - 0.48 10.2 9.6 1 9.2 1.9 2.2 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.12 ETN97304.1 - 0.56 10.2 15.5 1.9 8.5 6.1 2.3 1 1 1 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.15 ETN97304.1 - 0.58 9.7 7.6 0.7 9.4 7.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Seryl_tRNA_N PF02403.22 ETN97304.1 - 0.63 10.3 27.2 2.3 8.5 15.8 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RNA_pol_Rpb1_5 PF04998.17 ETN97304.1 - 0.83 9.0 7.2 1.1 8.6 7.2 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 COG2 PF06148.11 ETN97304.1 - 1 9.5 12.4 1.5 8.9 3.6 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 ALMT PF11744.8 ETN97304.1 - 1 8.1 13.2 1.2 7.8 13.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Med21 PF11221.8 ETN97304.1 - 2.1 8.6 22.1 2.6 8.3 6.1 2.5 2 0 0 2 2 2 0 Subunit 21 of Mediator complex DUF948 PF06103.11 ETN97304.1 - 2.2 8.6 10.4 2.6e+02 1.9 10.4 2.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Muted PF14942.6 ETN97304.1 - 2.5 8.4 24.4 6.4 7.1 14.1 2.1 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein Goodbye PF17109.5 ETN97304.1 - 2.6 8.5 10.9 0.74 10.3 3.5 2.4 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain zf-CRD PF17979.1 ETN97304.1 - 4.7 7.3 6.0 1.9 8.6 1.2 2.1 1 1 1 2 2 2 0 Cysteine rich domain with multizinc binding regions DUF4175 PF13779.6 ETN97304.1 - 4.8 5.0 8.4 12 3.7 8.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4446 PF14584.6 ETN97304.1 - 5.2 7.0 17.5 4.2 7.3 4.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) GvpG PF05120.12 ETN97304.1 - 5.5 7.1 13.5 1.9 8.5 6.9 2.7 2 1 1 3 3 3 0 Gas vesicle protein G TPR_8 PF13181.6 ETN97305.1 - 1.3e-12 46.8 4.2 1.1e-09 37.7 0.6 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97305.1 - 5.5e-11 41.7 2.2 1.9e-07 30.7 0.2 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97305.1 - 1.1e-10 41.6 0.0 1.5e-10 41.2 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97305.1 - 5.4e-09 35.5 4.6 9.3e-07 28.4 1.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97305.1 - 5.2e-07 29.2 0.1 0.0011 18.9 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97305.1 - 1e-06 28.4 0.0 0.00027 20.7 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97305.1 - 0.00025 21.5 0.1 0.0012 19.4 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN97305.1 - 0.00087 18.8 0.0 0.00091 18.7 0.0 1.0 1 0 0 1 1 1 1 MalT-like TPR region MIT PF04212.18 ETN97305.1 - 0.0045 17.0 3.3 0.0068 16.5 2.0 1.9 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 ETN97305.1 - 0.0048 16.6 0.2 0.006 16.3 0.2 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_11 PF13414.6 ETN97305.1 - 0.015 15.0 3.6 0.019 14.6 1.3 2.3 2 0 0 2 2 2 0 TPR repeat ECSIT PF06239.11 ETN97305.1 - 0.034 13.3 0.4 0.036 13.2 0.4 1.2 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway TPR_19 PF14559.6 ETN97305.1 - 0.043 14.3 0.0 0.17 12.4 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97305.1 - 0.053 13.3 1.7 0.11 12.3 1.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETN97305.1 - 0.062 14.2 0.0 0.83 10.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.12 ETN97305.1 - 0.076 13.7 0.4 0.25 12.1 0.1 2.0 2 0 0 2 2 2 0 Sel1 repeat TPR_17 PF13431.6 ETN97305.1 - 0.082 13.3 7.5 2.4 8.7 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat PRIMA1 PF16101.5 ETN97309.1 - 0.0063 16.5 12.3 0.015 15.3 12.3 1.6 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 baeRF_family3 PF18845.1 ETN97309.1 - 0.1 12.9 0.2 0.1 12.9 0.2 1.9 2 1 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 Pex19 PF04614.12 ETN97309.1 - 0.19 11.5 10.1 0.68 9.7 10.1 1.8 1 1 0 1 1 1 0 Pex19 protein family Mito_fiss_reg PF05308.11 ETN97309.1 - 0.52 10.4 20.8 0.089 12.9 17.2 1.6 2 1 0 2 2 2 0 Mitochondrial fission regulator FAM184 PF15665.5 ETN97309.1 - 1.4 8.6 15.2 0.086 12.6 9.9 1.6 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B DUF1676 PF07898.13 ETN97309.1 - 6.5 6.8 7.3 1.1 9.3 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) CAP_N PF01213.19 ETN97309.1 - 9.8 5.6 24.3 0.69 9.3 18.8 2.0 3 1 0 3 3 3 0 Adenylate cyclase associated (CAP) N terminal Cys_rich_VLP PF14194.6 ETN97311.1 - 0.0091 16.1 0.2 0.014 15.5 0.2 1.3 1 0 0 1 1 1 1 Cysteine-rich VLP Trypan_PARP PF05887.11 ETN97312.1 - 3.3 7.7 18.1 6.6 6.7 18.1 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pkinase PF00069.25 ETN97313.1 - 5.6e-06 25.9 0.0 6.2e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain NADH_B2 PF14813.6 ETN97313.1 - 0.087 12.6 0.1 0.24 11.2 0.1 1.7 1 0 0 1 1 1 0 NADH dehydrogenase 1 beta subcomplex subunit 2 AAA_lid_1 PF17857.1 ETN97314.1 - 0.038 14.2 0.1 0.062 13.5 0.1 1.4 1 0 0 1 1 1 0 AAA+ lid domain Kelch_6 PF13964.6 ETN97316.1 - 4.5e-06 26.8 1.4 0.0005 20.2 0.4 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETN97316.1 - 9.3e-06 25.6 0.9 0.00044 20.2 0.4 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN97316.1 - 2.3e-05 23.9 0.7 8e-05 22.1 0.1 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETN97316.1 - 5.1e-05 23.1 0.3 0.0019 18.1 0.4 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETN97316.1 - 0.017 15.4 0.0 0.071 13.4 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN97316.1 - 0.028 14.4 0.1 5.9 7.0 0.1 2.4 2 0 0 2 2 2 0 Kelch motif Pox_A31 PF05771.11 ETN97316.1 - 0.032 14.2 0.8 0.059 13.4 0.8 1.4 1 0 0 1 1 1 0 Poxvirus A31 protein WD40 PF00400.32 ETN97317.1 - 4.9e-08 33.5 0.4 8.3e-08 32.8 0.4 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 ETN97317.1 - 0.0028 16.4 0.2 0.0031 16.2 0.2 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Gag_p19 PF02228.16 ETN97317.1 - 0.07 13.6 0.1 0.13 12.7 0.1 1.6 1 1 0 1 1 1 0 Major core protein p19 FANCL_C PF11793.8 ETN97318.1 - 0.0029 17.8 2.1 0.0037 17.4 0.1 2.3 3 0 0 3 3 3 1 FANCL C-terminal domain Sushi PF00084.20 ETN97318.1 - 0.035 14.7 0.0 0.12 13.0 0.0 1.9 1 0 0 1 1 1 0 Sushi repeat (SCR repeat) OATP PF03137.20 ETN97319.1 - 0.027 12.8 0.1 0.027 12.8 0.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 ETN97319.1 - 0.036 13.1 0.4 0.042 12.9 0.4 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4199 PF13858.6 ETN97319.1 - 0.18 12.2 2.3 10 6.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) CRA PF06589.11 ETN97319.1 - 0.67 10.1 11.2 0.075 13.1 5.9 1.9 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) RIC3 PF15361.6 ETN97319.1 - 1.2 9.5 10.5 0.11 12.9 2.2 2.1 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 OAD_gamma PF04277.13 ETN97319.1 - 1.7 9.3 5.1 3.7 8.2 1.7 2.4 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain ELO PF01151.18 ETN97319.1 - 5.9 6.3 7.1 5.5 6.4 0.6 2.1 2 0 0 2 2 2 0 GNS1/SUR4 family YajC PF02699.15 ETN97319.1 - 7.6 6.5 8.1 31 4.5 4.6 2.5 2 1 0 2 2 2 0 Preprotein translocase subunit FeoB_associated PF12669.7 ETN97319.1 - 8.3 6.9 5.7 30 5.1 0.7 2.5 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Translin PF01997.16 ETN97320.1 - 0.1 12.5 7.6 0.097 12.6 5.4 2.0 2 1 0 2 2 2 0 Translin family CEP209_CC5 PF16574.5 ETN97320.1 - 0.12 12.5 13.7 0.23 11.6 13.7 1.4 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 FUSC PF04632.12 ETN97320.1 - 1.9 6.9 6.2 3 6.3 6.2 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family bZIP_2 PF07716.15 ETN97320.1 - 2.6 8.2 15.1 4.6 7.4 2.1 3.3 2 1 0 2 2 2 0 Basic region leucine zipper MCU PF04678.13 ETN97320.1 - 3.5 7.7 8.3 9.2 6.3 8.3 1.8 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF4164 PF13747.6 ETN97320.1 - 4.1 7.8 10.6 4.6 7.6 4.1 2.8 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) APG6_N PF17675.1 ETN97320.1 - 5.1 7.6 23.4 0.23 12.0 9.8 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region WD40 PF00400.32 ETN97321.1 - 3e-41 138.6 19.6 1.8e-10 41.2 0.2 5.7 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97321.1 - 7.9e-14 51.7 0.5 0.00011 22.4 0.0 4.5 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97321.1 - 4.6e-07 29.5 1.4 0.0099 15.2 0.1 2.9 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETN97321.1 - 9.8e-07 27.8 1.3 0.12 11.0 0.1 3.6 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETN97321.1 - 5.1e-06 25.7 2.1 1.4 7.8 0.0 4.7 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN97321.1 - 4.3e-05 23.3 0.4 0.95 9.5 0.0 3.7 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETN97321.1 - 0.02 14.2 1.3 0.35 10.2 0.3 2.3 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETN97321.1 - 0.075 11.6 0.1 0.15 10.6 0.1 1.4 2 0 0 2 2 2 0 Cytochrome D1 heme domain HSBP1 PF06825.12 ETN97323.1 - 0.0008 19.2 3.1 0.0014 18.4 3.1 1.4 1 0 0 1 1 1 1 Heat shock factor binding protein 1 SF-assemblin PF06705.11 ETN97323.1 - 0.0055 16.1 4.2 0.0057 16.0 4.2 1.0 1 0 0 1 1 1 1 SF-assemblin/beta giardin NPV_P10 PF05531.12 ETN97323.1 - 0.0085 16.5 4.0 0.0096 16.4 3.3 1.3 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein CdvA PF18822.1 ETN97323.1 - 0.012 15.5 2.5 0.015 15.1 2.5 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain DUF4533 PF15047.6 ETN97323.1 - 0.018 14.6 3.7 0.018 14.6 3.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) FliD_C PF07195.12 ETN97323.1 - 0.02 14.3 2.5 0.021 14.3 2.5 1.0 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Cauli_AT PF03233.13 ETN97323.1 - 0.032 14.2 2.1 0.033 14.1 2.1 1.2 1 0 0 1 1 1 0 Aphid transmission protein BST2 PF16716.5 ETN97323.1 - 0.033 14.8 5.8 0.041 14.5 5.8 1.4 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 YlbD_coat PF14071.6 ETN97323.1 - 0.041 14.2 4.2 0.044 14.0 4.2 1.3 1 1 0 1 1 1 0 Putative coat protein SapB_1 PF05184.15 ETN97323.1 - 0.058 13.4 3.6 1.9 8.6 0.1 2.7 2 1 0 2 2 2 0 Saposin-like type B, region 1 PKcGMP_CC PF16808.5 ETN97323.1 - 0.49 10.3 5.9 2.1 8.2 0.4 2.8 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4709 PF15821.5 ETN97324.1 - 0.02 15.2 0.7 0.02 15.2 0.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4709) O-antigen_lig PF13425.6 ETN97325.1 - 0.09 11.6 6.2 0.13 11.0 6.2 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Neur_chan_memb PF02932.16 ETN97325.1 - 1.3 9.0 7.0 1.8 8.6 7.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5480 PF17576.2 ETN97325.1 - 2.5 8.2 4.2 4.1 7.4 0.1 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5480) Mitofilin PF09731.9 ETN97325.1 - 3 6.6 19.0 3.8 6.2 19.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Herpes_LMP1 PF05297.11 ETN97325.1 - 4.6 6.3 9.6 5.9 6.0 9.6 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Merozoite_SPAM PF07133.11 ETN97326.1 - 4.8e-06 26.7 39.6 9e-06 25.8 39.6 1.4 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) Nop14 PF04147.12 ETN97326.1 - 3.2e-05 22.4 23.8 4e-05 22.1 23.8 1.1 1 0 0 1 1 1 1 Nop14-like family NPR3 PF03666.13 ETN97326.1 - 5.5e-05 22.2 14.3 7.3e-05 21.7 14.3 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 ETN97326.1 - 0.00019 19.9 21.0 0.00023 19.6 21.0 1.2 1 0 0 1 1 1 1 CDC45-like protein Presenilin PF01080.17 ETN97326.1 - 0.00054 18.9 16.8 0.00074 18.4 16.8 1.3 1 0 0 1 1 1 1 Presenilin DUF2151 PF10221.9 ETN97326.1 - 0.0042 15.7 16.6 0.0053 15.4 16.6 1.2 1 0 0 1 1 1 1 Cell cycle and development regulator SAPS PF04499.15 ETN97326.1 - 0.0084 15.0 13.0 0.011 14.6 13.0 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Dynactin_p62 PF05502.13 ETN97326.1 - 0.0093 14.8 8.3 0.012 14.4 8.3 1.1 1 0 0 1 1 1 1 Dynactin p62 family BUD22 PF09073.10 ETN97326.1 - 0.012 15.0 29.4 0.017 14.5 29.4 1.2 1 0 0 1 1 1 0 BUD22 Spore_coat_CotO PF14153.6 ETN97326.1 - 0.013 15.5 29.2 0.019 14.9 29.2 1.2 1 0 0 1 1 1 0 Spore coat protein CotO SDA1 PF05285.12 ETN97326.1 - 0.018 14.5 31.6 0.027 13.9 31.6 1.2 1 0 0 1 1 1 0 SDA1 LAP1C PF05609.12 ETN97326.1 - 0.028 13.5 12.4 0.036 13.2 12.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2052 PF09747.9 ETN97326.1 - 0.04 14.0 32.1 0.068 13.3 32.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Zip PF02535.22 ETN97326.1 - 0.072 12.3 10.8 0.057 12.6 9.5 1.5 2 0 0 2 2 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ETN97326.1 - 0.098 12.5 32.0 0.15 11.8 32.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 ETN97326.1 - 0.1 10.5 15.3 0.14 10.1 15.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4045 PF13254.6 ETN97326.1 - 0.12 12.0 20.7 0.16 11.5 20.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SLC12 PF03522.15 ETN97326.1 - 0.12 11.3 18.5 0.17 10.9 18.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 ETN97326.1 - 0.16 10.7 14.5 0.21 10.3 14.5 1.1 1 0 0 1 1 1 0 Raftlin DUF3807 PF12720.7 ETN97326.1 - 0.2 11.9 26.8 0.32 11.3 26.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DNA_pol_phi PF04931.13 ETN97326.1 - 0.21 9.7 31.5 0.33 9.0 31.5 1.4 1 0 0 1 1 1 0 DNA polymerase phi ALMT PF11744.8 ETN97326.1 - 0.21 10.3 18.0 0.28 10.0 18.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MDM10 PF12519.8 ETN97326.1 - 0.31 9.9 15.2 0.41 9.5 15.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Mitofilin PF09731.9 ETN97326.1 - 0.35 9.6 27.1 0.46 9.3 27.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PPL5 PF18168.1 ETN97326.1 - 0.38 10.0 13.2 0.68 9.2 13.2 1.5 1 0 0 1 1 1 0 Prim-pol family 5 Neur_chan_memb PF02932.16 ETN97326.1 - 0.47 10.5 11.1 0.74 9.8 11.1 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 ETN97326.1 - 0.47 9.8 35.8 0.71 9.2 35.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC27 PF09507.10 ETN97326.1 - 0.49 9.7 36.8 0.71 9.2 36.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF2828 PF11443.8 ETN97326.1 - 0.53 8.3 18.5 0.72 7.9 18.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) SOBP PF15279.6 ETN97326.1 - 0.96 10.0 6.4 1.4 9.4 6.4 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein Pannexin_like PF12534.8 ETN97326.1 - 0.97 8.5 13.9 1.5 7.8 13.9 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Astro_capsid_p PF12226.8 ETN97326.1 - 1.2 8.3 14.9 1.7 7.7 14.9 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein HSP70 PF00012.20 ETN97326.1 - 1.7 6.7 20.2 2.1 6.4 20.2 1.1 1 0 0 1 1 1 0 Hsp70 protein RNA_pol_3_Rpc31 PF11705.8 ETN97326.1 - 2.4 8.4 31.2 4.6 7.4 31.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Gti1_Pac2 PF09729.9 ETN97326.1 - 2.6 8.1 16.3 4.7 7.3 16.3 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family MCM_bind PF09739.9 ETN97326.1 - 2.7 6.4 20.4 3.5 6.0 20.4 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF262 PF03235.14 ETN97326.1 - 2.7 8.1 16.9 0.78 9.9 13.8 1.7 2 0 0 2 2 1 0 Protein of unknown function DUF262 PPP4R2 PF09184.11 ETN97326.1 - 2.8 7.5 31.9 4.3 6.9 31.9 1.3 1 0 0 1 1 1 0 PPP4R2 Sec62 PF03839.16 ETN97326.1 - 3.4 7.1 24.9 7.3 6.0 24.9 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 TRAPPC-Trs85 PF12739.7 ETN97326.1 - 3.6 6.4 12.1 5.7 5.8 12.1 1.5 1 1 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Band_3_cyto PF07565.13 ETN97326.1 - 4.1 7.1 13.1 7.7 6.2 13.1 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF5427 PF10310.9 ETN97326.1 - 4.4 6.2 27.5 6.1 5.7 27.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) AAA_11 PF13086.6 ETN97326.1 - 4.9 6.9 20.6 7.9 6.2 20.6 1.4 1 0 0 1 1 1 0 AAA domain Endostatin PF06482.11 ETN97326.1 - 5 6.5 10.8 7.1 6.0 10.8 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Vfa1 PF08432.10 ETN97326.1 - 5.1 7.4 34.9 9.7 6.5 34.9 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 BORG_CEP PF14957.6 ETN97326.1 - 5.4 8.2 14.5 11 7.1 14.5 1.5 1 0 0 1 1 1 0 Cdc42 effector Rtf2 PF04641.12 ETN97326.1 - 5.5 6.3 24.8 8.4 5.7 24.8 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4746 PF15928.5 ETN97326.1 - 5.8 6.2 33.4 9.2 5.6 33.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM60A PF15396.6 ETN97326.1 - 8.5 6.3 18.7 15 5.6 18.7 1.4 1 0 0 1 1 1 0 Protein Family FAM60A U79_P34 PF03064.16 ETN97326.1 - 8.7 5.6 28.4 15 4.9 28.4 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Membralin PF09746.9 ETN97326.1 - 8.7 5.3 12.6 13 4.7 12.6 1.3 1 0 0 1 1 1 0 Tumour-associated protein Paramyxo_ncap PF00973.19 ETN97326.1 - 9.1 5.1 15.3 12 4.6 15.3 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AIG1 PF04548.16 ETN97328.1 - 9.2e-22 77.4 0.0 1.8e-21 76.4 0.0 1.5 1 0 0 1 1 1 1 AIG1 family MIB_HERC2 PF06701.13 ETN97328.1 - 5.8e-14 52.1 2.9 1.3e-13 51.0 2.9 1.6 1 0 0 1 1 1 1 Mib_herc2 MMR_HSR1 PF01926.23 ETN97328.1 - 9.3e-09 35.4 0.0 2.1e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETN97328.1 - 3.9e-06 27.0 1.8 0.0057 16.7 0.0 3.1 3 0 0 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 ETN97328.1 - 0.00025 21.0 0.4 0.0012 18.8 0.1 2.2 2 1 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 ETN97328.1 - 0.01 15.6 0.2 1.9 8.2 0.0 3.0 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein IIGP PF05049.13 ETN97328.1 - 0.011 14.8 0.3 0.019 14.0 0.3 1.6 1 1 0 1 1 1 0 Interferon-inducible GTPase (IIGP) GTP_EFTU PF00009.27 ETN97328.1 - 0.016 14.8 0.8 2.3 7.7 0.1 2.9 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ETN97328.1 - 0.017 15.4 0.1 0.056 13.7 0.0 2.0 2 1 0 2 2 2 0 AAA domain Septin PF00735.18 ETN97328.1 - 0.029 13.7 0.6 0.12 11.6 0.0 2.1 2 0 0 2 2 2 0 Septin AAA_18 PF13238.6 ETN97328.1 - 0.031 14.8 0.6 0.085 13.4 0.1 2.2 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETN97328.1 - 0.094 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FeoB_N PF02421.18 ETN97328.1 - 0.14 11.7 0.0 0.63 9.6 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B PduV-EutP PF10662.9 ETN97328.1 - 0.22 11.3 0.5 5.6 6.7 0.1 3.0 2 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TrbL PF04610.14 ETN97330.1 - 1.1e-05 25.4 2.5 1.4e-05 24.9 2.5 1.2 1 0 0 1 1 1 1 TrbL/VirB6 plasmid conjugal transfer protein NMT PF01233.19 ETN97330.1 - 0.1 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain ZapB PF06005.12 ETN97331.1 - 0.0002 21.7 27.6 0.052 14.0 7.1 3.1 3 0 0 3 3 3 2 Cell division protein ZapB bZIP_1 PF00170.21 ETN97331.1 - 0.0019 18.2 23.1 0.021 14.9 3.2 3.5 3 1 0 3 3 3 2 bZIP transcription factor DUF3450 PF11932.8 ETN97331.1 - 0.0038 16.6 2.0 0.0038 16.6 2.0 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF3450) Ead_Ea22 PF13935.6 ETN97331.1 - 0.0047 17.6 7.5 0.055 14.1 6.9 2.4 1 1 0 1 1 1 1 Ead/Ea22-like protein Kinesin_assoc PF16183.5 ETN97331.1 - 0.0061 16.7 4.8 0.0091 16.2 4.8 1.3 1 0 0 1 1 1 1 Kinesin-associated KLRAQ PF10205.9 ETN97331.1 - 0.0085 16.3 8.0 0.0085 16.3 8.0 2.9 1 1 2 3 3 3 1 Predicted coiled-coil domain-containing protein ATG16 PF08614.11 ETN97331.1 - 0.0094 16.2 21.5 0.083 13.1 2.2 2.8 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) Vps51 PF08700.11 ETN97331.1 - 0.017 15.2 8.6 1.7 8.8 0.1 3.6 2 2 0 3 3 3 0 Vps51/Vps67 HAUS-augmin3 PF14932.6 ETN97331.1 - 0.024 14.2 20.8 0.034 13.7 13.1 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 APG6_N PF17675.1 ETN97331.1 - 0.027 15.0 21.7 0.067 13.7 10.2 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region Rho_Binding PF08912.11 ETN97331.1 - 0.029 15.2 21.9 0.13 13.1 5.4 3.4 2 1 1 3 3 3 0 Rho Binding YabA PF06156.13 ETN97331.1 - 0.036 14.7 17.5 1.1 9.9 4.2 3.1 2 1 1 3 3 3 0 Initiation control protein YabA Phage_GP20 PF06810.11 ETN97331.1 - 0.038 13.8 18.3 0.067 13.0 3.2 3.0 1 1 2 3 3 3 0 Phage minor structural protein GP20 DUF1192 PF06698.11 ETN97331.1 - 0.041 13.9 7.4 3.7 7.7 0.9 3.5 3 1 1 4 4 3 0 Protein of unknown function (DUF1192) KASH_CCD PF14662.6 ETN97331.1 - 0.054 13.3 26.0 4.5 7.1 26.0 2.8 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Rx_N PF18052.1 ETN97331.1 - 0.072 13.4 10.6 2.4 8.5 0.2 3.1 2 1 1 3 3 3 0 Rx N-terminal domain DUF4474 PF14751.6 ETN97331.1 - 0.098 12.0 0.4 0.14 11.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) TPR_MLP1_2 PF07926.12 ETN97331.1 - 0.11 12.6 20.3 5.8 7.0 0.3 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DHR10 PF18595.1 ETN97331.1 - 0.13 12.3 25.5 0.051 13.6 7.7 3.1 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DUF4618 PF15397.6 ETN97331.1 - 0.14 11.6 19.2 0.44 9.9 2.5 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) TolA_bind_tri PF16331.5 ETN97331.1 - 0.15 12.2 23.2 0.21 11.7 0.1 3.5 3 1 0 3 3 3 0 TolA binding protein trimerisation ADIP PF11559.8 ETN97331.1 - 0.32 11.1 22.8 0.37 10.9 2.9 3.1 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Prefoldin PF02996.17 ETN97331.1 - 0.36 10.7 16.2 2.5 8.1 2.4 3.2 3 0 0 3 3 3 0 Prefoldin subunit THOC7 PF05615.13 ETN97331.1 - 0.37 11.1 19.1 1.1 9.5 4.0 3.1 2 1 1 3 3 3 0 Tho complex subunit 7 UPF0242 PF06785.11 ETN97331.1 - 0.38 10.8 22.6 0.3 11.2 16.3 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cep57_MT_bd PF06657.13 ETN97331.1 - 0.47 10.9 14.5 1.8 9.1 0.5 3.3 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 TSC22 PF01166.18 ETN97331.1 - 0.51 10.7 18.6 1.5 9.2 3.0 3.3 2 1 1 3 3 3 0 TSC-22/dip/bun family Prefoldin_2 PF01920.20 ETN97331.1 - 0.57 10.2 23.5 2.6 8.0 4.1 3.3 2 1 1 3 3 3 0 Prefoldin subunit ApoO PF09769.9 ETN97331.1 - 0.6 10.1 2.5 6.4 6.8 0.0 2.7 2 1 1 3 3 3 0 Apolipoprotein O DUF1664 PF07889.12 ETN97331.1 - 0.61 10.1 14.5 0.44 10.6 5.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 ETN97331.1 - 0.7 10.1 20.0 1.1 9.4 12.9 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 ERM PF00769.19 ETN97331.1 - 0.72 9.6 20.1 0.21 11.3 14.3 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Seryl_tRNA_N PF02403.22 ETN97331.1 - 0.75 10.1 20.9 1.1 9.5 5.1 2.9 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.9 ETN97331.1 - 0.92 9.9 12.9 7.8 6.9 0.5 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 ETN97331.1 - 1.1 8.1 21.9 0.51 9.2 12.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF724 PF05266.14 ETN97331.1 - 1.1 9.0 15.4 0.7 9.7 8.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Med30 PF11315.8 ETN97331.1 - 1.5 9.0 13.0 41 4.3 13.0 2.9 1 1 0 1 1 1 0 Mediator complex subunit 30 Golgin_A5 PF09787.9 ETN97331.1 - 1.5 8.2 22.8 0.29 10.6 12.3 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 GrpE PF01025.19 ETN97331.1 - 1.8 8.2 18.2 0.74 9.5 4.2 3.0 2 1 1 3 3 3 0 GrpE CENP-F_leu_zip PF10473.9 ETN97331.1 - 2.1 8.4 24.9 3 7.9 15.8 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Alpha-E PF04168.12 ETN97331.1 - 2.3 7.9 6.9 0.39 10.5 2.4 1.7 2 0 0 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. FapA PF03961.13 ETN97331.1 - 2.6 6.6 16.7 1.6 7.2 10.4 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Cnn_1N PF07989.11 ETN97331.1 - 3 8.1 21.2 1.9 8.7 3.8 3.3 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DivIC PF04977.15 ETN97331.1 - 3.1 7.6 20.8 8 6.3 8.2 3.9 2 1 1 3 3 3 0 Septum formation initiator DUF4208 PF13907.6 ETN97331.1 - 3.2 8.3 10.3 0.22 12.0 0.8 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4208) FlaC_arch PF05377.11 ETN97331.1 - 3.2 8.2 13.0 53 4.3 7.5 3.6 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) Cortex-I_coil PF09304.10 ETN97331.1 - 3.6 7.8 16.1 6.2 7.1 9.0 2.1 2 0 0 2 2 2 0 Cortexillin I, coiled coil HALZ PF02183.18 ETN97331.1 - 3.7 7.8 17.5 0.2 11.9 1.5 3.7 3 1 0 3 3 3 0 Homeobox associated leucine zipper TMF_DNA_bd PF12329.8 ETN97331.1 - 3.8 7.6 23.1 3.3 7.8 7.3 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding KELK PF15796.5 ETN97331.1 - 4 8.0 20.7 0.13 12.8 7.7 3.1 2 2 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Occludin_ELL PF07303.13 ETN97331.1 - 4.1 8.2 12.3 4.3 8.1 2.0 3.1 2 1 1 3 3 3 0 Occludin homology domain PRKG1_interact PF15898.5 ETN97331.1 - 4.5 8.2 21.6 2.3 9.2 5.0 2.6 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Spc24 PF08286.11 ETN97331.1 - 5 7.4 22.4 13 6.1 2.8 3.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.10 ETN97331.1 - 5 7.3 17.5 0.9 9.7 7.3 2.3 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF465 PF04325.13 ETN97331.1 - 5.7 7.1 9.5 12 6.0 0.1 3.7 4 1 0 4 4 3 0 Protein of unknown function (DUF465) betaPIX_CC PF16523.5 ETN97331.1 - 5.9 6.8 14.7 0.08 12.8 2.4 2.9 2 1 1 3 3 3 0 betaPIX coiled coil Prp19 PF08606.11 ETN97331.1 - 6.1 6.9 10.0 3.6 7.6 0.3 3.2 3 0 0 3 3 3 0 Prp19/Pso4-like DUF2508 PF10704.9 ETN97331.1 - 6.6 7.0 12.6 9.7 6.4 1.7 3.7 2 1 2 4 4 4 0 Protein of unknown function (DUF2508) DUF883 PF05957.13 ETN97331.1 - 6.6 7.4 9.3 8 7.1 0.4 2.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) CorA PF01544.18 ETN97331.1 - 6.8 5.9 10.7 5.8 6.1 5.1 2.0 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF3552 PF12072.8 ETN97331.1 - 7.3 6.0 21.8 58 3.0 11.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Tup_N PF08581.10 ETN97331.1 - 7.4 7.0 15.1 1.6 9.1 1.6 3.2 2 1 0 3 3 3 0 Tup N-terminal Ax_dynein_light PF10211.9 ETN97331.1 - 7.6 6.4 22.4 22 5.0 13.1 3.0 2 1 0 2 2 2 0 Axonemal dynein light chain NPV_P10 PF05531.12 ETN97331.1 - 8 7.0 10.5 2.8e+02 2.1 0.0 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Uso1_p115_C PF04871.13 ETN97331.1 - 8 6.8 21.1 9.3 6.6 2.5 2.5 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region KMP11 PF03037.16 ETN97332.1 - 0.0098 16.7 0.1 0.013 16.3 0.1 1.2 1 0 0 1 1 1 1 Kinetoplastid membrane protein 11 HEAT PF02985.22 ETN97334.1 - 0.0012 19.0 0.0 0.0095 16.1 0.0 2.5 2 0 0 2 2 2 1 HEAT repeat bZIP_1 PF00170.21 ETN97335.1 - 0.00063 19.8 1.7 0.00063 19.8 1.7 2.4 3 0 0 3 3 3 1 bZIP transcription factor KASH_CCD PF14662.6 ETN97335.1 - 0.0021 17.9 4.9 0.0023 17.8 4.9 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH MAGSP PF03082.14 ETN97335.1 - 0.0026 17.4 2.2 0.0034 17.0 2.2 1.2 1 0 0 1 1 1 1 Male accessory gland secretory protein DUF465 PF04325.13 ETN97335.1 - 0.004 17.2 1.2 0.014 15.4 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF465) YabA PF06156.13 ETN97335.1 - 0.0052 17.4 2.4 0.0063 17.1 2.4 1.2 1 0 0 1 1 1 1 Initiation control protein YabA DivIC PF04977.15 ETN97335.1 - 0.0079 16.0 1.1 0.0079 16.0 1.1 1.5 2 0 0 2 2 2 1 Septum formation initiator Tho2 PF11262.8 ETN97335.1 - 0.0087 15.3 1.3 0.011 14.9 1.3 1.1 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 Tropomyosin_1 PF12718.7 ETN97335.1 - 0.013 15.7 1.8 0.023 14.9 1.8 1.4 1 0 0 1 1 1 0 Tropomyosin like TSC22 PF01166.18 ETN97335.1 - 0.016 15.5 2.2 3.6 8.0 0.4 2.4 1 1 1 2 2 2 0 TSC-22/dip/bun family TMCO5 PF14992.6 ETN97335.1 - 0.016 14.8 3.8 0.018 14.6 3.8 1.2 1 0 0 1 1 1 0 TMCO5 family Cnn_1N PF07989.11 ETN97335.1 - 0.034 14.3 3.7 0.036 14.2 1.3 2.1 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DUF4829 PF16111.5 ETN97335.1 - 0.14 12.9 5.7 0.18 12.6 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) bZIP_2 PF07716.15 ETN97335.1 - 1.1 9.4 6.0 0.28 11.3 1.5 2.2 2 0 0 2 2 2 0 Basic region leucine zipper Y_phosphatase3 PF13350.6 ETN97336.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family CMS1 PF14617.6 ETN97337.1 - 0.015 14.6 8.9 0.017 14.5 8.9 1.0 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit SR-25 PF10500.9 ETN97337.1 - 0.32 10.6 17.5 0.31 10.6 17.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCDC71L PF15374.6 ETN97337.1 - 0.84 8.8 10.6 0.92 8.7 10.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L DUF1168 PF06658.12 ETN97337.1 - 3.7 7.3 16.8 4.5 7.1 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) AP3D1 PF06375.11 ETN97337.1 - 6.7 6.9 14.5 7.7 6.7 14.5 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 G-alpha PF00503.20 ETN97338.1 - 4.2e-43 147.9 5.4 4.4e-43 147.8 5.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETN97338.1 - 3.7e-10 39.5 0.3 7.2e-10 38.6 0.3 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETN97338.1 - 0.0016 17.8 0.3 0.0019 17.6 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ETN97338.1 - 0.0031 17.0 0.1 0.005 16.3 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit WWE PF02825.20 ETN97339.1 - 5.3e-07 30.1 0.1 1e-06 29.2 0.1 1.5 1 0 0 1 1 1 1 WWE domain Spore_YhcN_YlaJ PF09580.10 ETN97341.1 - 5.4 7.1 7.4 31 4.6 0.3 2.7 2 0 0 2 2 2 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) WD40 PF00400.32 ETN97342.1 - 2e-14 53.7 8.5 0.00018 22.2 0.1 4.5 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN97342.1 - 6.9e-05 21.7 0.1 0.03 13.0 0.1 2.6 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97342.1 - 7.7e-05 22.9 0.1 6.9 7.0 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain KduI PF04962.12 ETN97342.1 - 0.015 14.6 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 KduI/IolB family DUF1541 PF07563.11 ETN97342.1 - 0.028 14.3 0.0 0.096 12.6 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1541) Ribosomal_L21e PF01157.18 ETN97342.1 - 0.23 11.3 1.2 11 5.9 0.1 2.3 1 1 1 2 2 2 0 Ribosomal protein L21e PT PF04886.12 ETN97344.1 - 1.4e-25 88.5 132.9 6.9e-07 28.7 14.3 8.0 3 2 4 7 7 7 5 PT repeat AID PF18767.1 ETN97344.1 - 0.039 14.0 0.1 0.039 14.0 0.1 2.3 2 0 0 2 2 2 0 Activation induced deaminase RAP PF08373.10 ETN97345.1 - 0.11 12.6 0.5 0.11 12.6 0.5 1.9 2 1 0 2 2 2 0 RAP domain FAST_1 PF06743.15 ETN97346.1 - 0.074 13.0 0.1 0.88 9.6 0.0 2.8 2 1 1 3 3 3 0 FAST kinase-like protein, subdomain 1 FapA PF03961.13 ETN97346.1 - 1.1 7.7 8.5 1.6 7.3 8.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A ESP PF16590.5 ETN97347.1 - 2 8.7 4.8 10 6.5 0.0 3.1 2 1 1 3 3 3 0 Exocrine gland-secreting peptide CIAPIN1 PF05093.13 ETN97348.1 - 0.038 14.5 3.3 0.071 13.6 3.3 1.4 1 0 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF3819 PF12842.7 ETN97350.1 - 0.005 16.8 0.4 0.0051 16.7 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) Rib_recp_KP_reg PF05104.12 ETN97351.1 - 0.042 14.9 1.7 0.061 14.4 1.7 1.2 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region DUF5528 PF17666.1 ETN97351.1 - 5 7.1 6.7 0.4 10.6 0.6 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5528) ArsA_HSP20 PF17886.1 ETN97352.1 - 0.006 16.1 0.0 0.0073 15.8 0.0 1.2 1 0 0 1 1 1 1 HSP20-like domain found in ArsA TPR_12 PF13424.6 ETN97353.1 - 4.7e-47 158.2 3.7 2.8e-21 75.6 0.1 3.2 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97353.1 - 3.4e-28 96.7 1.8 1.8e-08 34.0 0.1 5.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97353.1 - 8.7e-23 78.6 3.4 5.4e-09 35.5 0.1 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97353.1 - 1.1e-18 65.8 15.5 8.9e-07 28.6 0.6 4.6 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97353.1 - 1.2e-18 66.0 14.8 1.1e-06 28.2 0.3 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97353.1 - 2.7e-15 55.1 7.5 5.3e-05 23.0 0.2 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97353.1 - 1.9e-06 28.1 5.4 0.099 13.3 0.1 4.1 4 1 1 5 5 4 2 Tetratricopeptide repeat PPR PF01535.20 ETN97353.1 - 5.3e-06 26.3 1.0 0.9 9.9 0.0 4.1 4 0 0 4 4 4 2 PPR repeat TPR_14 PF13428.6 ETN97353.1 - 5.8e-06 26.7 0.0 2.8 9.0 0.0 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97353.1 - 8.4e-05 23.1 0.0 0.83 10.4 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97353.1 - 0.00015 21.9 4.7 0.72 10.4 0.1 4.5 3 2 0 3 3 3 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETN97353.1 - 0.00067 19.4 4.0 0.021 14.5 3.9 2.1 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_MalT PF17874.1 ETN97353.1 - 0.001 18.5 0.6 0.005 16.3 0.2 1.9 1 1 1 2 2 2 1 MalT-like TPR region DUF5113 PF17140.4 ETN97353.1 - 0.002 18.0 5.8 0.6 9.9 0.3 3.4 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETN97353.1 - 0.0038 16.9 20.5 0.07 12.8 0.6 5.5 4 3 3 7 7 6 2 TPR repeat Sel1 PF08238.12 ETN97353.1 - 0.012 16.3 4.7 1.4 9.7 0.2 3.5 3 1 0 3 3 3 0 Sel1 repeat RPN7 PF10602.9 ETN97353.1 - 0.029 14.1 3.0 4.9 6.8 0.1 2.8 3 1 0 3 3 3 0 26S proteasome subunit RPN7 MIT PF04212.18 ETN97353.1 - 0.035 14.2 10.3 6.1 7.0 5.4 3.7 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF627 PF04781.12 ETN97353.1 - 0.079 13.0 1.3 0.22 11.6 0.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF627) NSF PF02071.20 ETN97353.1 - 0.91 10.6 13.4 5.1 8.3 0.2 4.4 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_MLP1_2 PF07926.12 ETN97354.1 - 1.8e-05 24.8 37.7 0.0043 17.1 6.9 3.1 1 1 2 3 3 3 3 TPR/MLP1/MLP2-like protein Muted PF14942.6 ETN97354.1 - 0.014 15.7 16.0 0.014 15.7 16.0 2.9 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DUF1192 PF06698.11 ETN97354.1 - 0.025 14.6 5.2 0.044 13.8 0.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1192) Peptidase_S39 PF02122.15 ETN97354.1 - 0.087 12.3 1.0 0.16 11.5 1.0 1.6 1 0 0 1 1 1 0 Peptidase S39 zf-C2H2_aberr PF17017.5 ETN97354.1 - 0.17 12.0 0.3 0.17 12.0 0.3 3.1 1 1 2 3 3 3 0 Aberrant zinc-finger Mod_r PF07200.13 ETN97354.1 - 0.83 9.8 39.0 2.6 8.1 3.6 3.4 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Ribosomal_L22 PF00237.19 ETN97354.1 - 1.6 9.0 14.7 4.7 7.5 0.0 4.0 2 1 0 2 2 2 0 Ribosomal protein L22p/L17e V_ATPase_I PF01496.19 ETN97354.1 - 1.8 6.4 31.8 0.07 11.0 20.6 2.0 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Spectrin PF00435.21 ETN97354.1 - 6.5 7.3 32.6 3.9 8.0 13.3 3.7 1 1 2 4 4 4 0 Spectrin repeat DASH_Dam1 PF08653.10 ETN97354.1 - 8.3 6.3 8.6 29 4.6 0.5 3.8 3 1 0 3 3 3 0 DASH complex subunit Dam1 Alpha_E1_glycop PF01589.16 ETN97355.1 - 0.16 10.6 0.0 0.18 10.5 0.0 1.0 1 0 0 1 1 1 0 Alphavirus E1 glycoprotein DUF3246 PF11596.8 ETN97356.1 - 0.012 15.0 8.6 0.015 14.7 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) CDC45 PF02724.14 ETN97356.1 - 0.16 10.2 13.7 0.18 10.0 13.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETN97356.1 - 0.51 8.4 11.1 0.58 8.2 11.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MCM_bind PF09739.9 ETN97356.1 - 5.9 5.2 10.4 6.8 5.0 10.4 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor AAA_8 PF12780.7 ETN97359.1 - 9.1e-05 21.9 0.0 0.00025 20.4 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA PF00004.29 ETN97359.1 - 0.0002 21.8 0.0 0.00084 19.8 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETN97359.1 - 0.0003 20.8 0.0 0.00081 19.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETN97359.1 - 0.00062 20.1 1.0 0.012 15.9 0.0 3.4 5 0 0 5 5 5 1 AAA domain AAA_7 PF12775.7 ETN97359.1 - 0.00083 18.9 0.0 0.0039 16.7 0.0 2.2 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETN97359.1 - 0.0016 19.0 1.1 0.011 16.3 0.0 2.7 2 1 0 2 2 2 1 ABC transporter DUF815 PF05673.13 ETN97359.1 - 0.0045 16.2 0.0 0.011 14.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Tenui_N PF05733.11 ETN97359.1 - 0.0047 16.5 0.0 0.0097 15.5 0.0 1.5 1 0 0 1 1 1 1 Tenuivirus/Phlebovirus nucleocapsid protein RsgA_GTPase PF03193.16 ETN97359.1 - 0.013 15.4 0.2 0.037 13.9 0.0 1.8 2 0 0 2 2 2 0 RsgA GTPase NACHT PF05729.12 ETN97359.1 - 0.015 15.2 2.1 2 8.3 0.1 3.3 3 1 0 3 3 3 0 NACHT domain AAA_16 PF13191.6 ETN97359.1 - 0.022 15.2 0.1 0.45 10.9 0.1 3.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 ETN97359.1 - 0.046 13.7 0.0 0.046 13.7 0.0 3.1 4 0 0 4 4 4 0 AAA domain PduV-EutP PF10662.9 ETN97359.1 - 0.071 12.8 0.1 0.17 11.7 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 ETN97359.1 - 0.073 12.1 0.2 0.7 8.9 0.1 2.3 2 0 0 2 2 2 0 MCM P-loop domain AAA_19 PF13245.6 ETN97359.1 - 0.083 13.2 0.1 20 5.5 0.1 2.6 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ETN97359.1 - 0.084 12.8 5.1 0.88 9.4 0.1 3.6 4 0 0 4 4 4 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ETN97359.1 - 0.13 12.3 0.1 0.45 10.5 0.1 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Roc PF08477.13 ETN97359.1 - 0.16 12.2 2.7 5.6 7.2 0.1 3.6 3 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 ETN97359.1 - 0.33 11.4 0.0 0.33 11.4 0.0 3.5 2 1 0 2 2 1 0 AAA domain CUE PF02845.16 ETN97362.1 - 0.0026 17.4 0.1 0.0065 16.1 0.1 1.7 1 0 0 1 1 1 1 CUE domain KBP_C PF12309.8 ETN97362.1 - 0.0072 15.9 1.5 0.0074 15.9 1.5 1.1 1 0 0 1 1 1 1 KIF-1 binding protein C terminal DUF2239 PF09998.9 ETN97362.1 - 0.12 12.2 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2239) DUF4407 PF14362.6 ETN97362.1 - 0.15 11.4 1.0 0.2 11.0 0.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HC2 PF07382.11 ETN97363.1 - 0.009 16.1 13.7 0.0098 16.0 13.7 1.1 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 Connexin PF00029.19 ETN97365.1 - 0.00063 19.6 1.4 0.00072 19.4 1.4 1.2 1 0 0 1 1 1 1 Connexin UPF0767 PF15990.5 ETN97365.1 - 0.017 15.2 1.2 0.022 14.9 1.2 1.2 1 0 0 1 1 1 0 UPF0767 family CLN3 PF02487.17 ETN97365.1 - 0.022 13.8 0.2 0.025 13.6 0.2 1.1 1 0 0 1 1 1 0 CLN3 protein EOS1 PF12326.8 ETN97365.1 - 0.052 13.5 0.1 0.052 13.5 0.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF3987 PF13148.6 ETN97365.1 - 0.28 10.2 1.4 0.33 9.9 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) NARP1 PF12569.8 ETN97365.1 - 0.76 8.6 12.6 0.93 8.3 12.6 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Mpp10 PF04006.12 ETN97365.1 - 0.82 8.0 15.0 0.89 7.9 15.0 1.0 1 0 0 1 1 1 0 Mpp10 protein Peptidase_C14 PF00656.22 ETN97366.1 - 1.1e-08 35.4 1.2 2.6e-07 30.9 1.2 2.4 1 1 0 1 1 1 1 Caspase domain DUF3584 PF12128.8 ETN97370.1 - 0.17 9.3 30.1 0.26 8.8 30.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 ETN97370.1 - 1.2 8.0 43.9 0.021 13.7 34.0 2.5 2 1 1 3 3 3 0 Spc7 kinetochore protein Laminin_II PF06009.12 ETN97370.1 - 8.3 6.4 26.4 0.028 14.4 6.2 3.2 1 1 2 3 3 3 0 Laminin Domain II APG6_N PF17675.1 ETN97370.1 - 9.9 6.7 38.9 9.9 6.7 9.6 2.8 2 0 0 2 2 2 0 Apg6 coiled-coil region zf-AD PF07776.15 ETN97371.1 - 5.1 7.4 8.0 0.31 11.3 0.5 2.9 3 0 0 3 3 3 0 Zinc-finger associated domain (zf-AD) JmjN PF02375.17 ETN97372.1 - 0.19 11.7 0.9 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 jmjN domain TPR_12 PF13424.6 ETN97373.1 - 2.7e-33 114.1 5.8 1.9e-17 63.3 0.4 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97373.1 - 2.1e-25 87.8 1.2 6.3e-09 35.4 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97373.1 - 2.5e-21 74.5 12.4 1.1e-09 37.7 1.6 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97373.1 - 8.6e-21 72.3 7.0 2.8e-08 33.2 0.5 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97373.1 - 4.1e-17 60.9 11.4 9.4e-07 28.6 1.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97373.1 - 6.2e-16 57.2 0.3 8.5e-06 25.4 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97373.1 - 5.2e-11 42.0 13.5 0.00064 19.4 0.4 4.2 3 1 1 4 4 4 3 TPR repeat SHNi-TPR PF10516.9 ETN97373.1 - 1.7e-07 30.6 0.0 0.027 13.9 0.0 3.2 3 0 0 3 3 3 2 SHNi-TPR TPR_6 PF13174.6 ETN97373.1 - 4.1e-07 30.2 0.8 0.025 15.2 0.0 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97373.1 - 4.7e-07 30.1 0.0 0.098 13.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97373.1 - 3.6e-06 26.9 8.3 0.0096 15.7 0.5 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETN97373.1 - 6e-06 26.3 13.0 0.0015 18.8 1.8 3.8 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97373.1 - 1.8e-05 25.3 0.0 0.81 10.4 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat SNAP PF14938.6 ETN97373.1 - 0.00011 21.8 0.9 0.00018 21.0 0.9 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETN97373.1 - 0.00029 20.9 5.9 0.0043 17.1 0.2 3.1 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETN97373.1 - 0.0014 18.1 0.0 0.0017 17.8 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region TPR_19 PF14559.6 ETN97373.1 - 0.0024 18.3 0.4 0.06 13.9 0.2 2.6 1 1 0 2 2 2 1 Tetratricopeptide repeat DUF627 PF04781.12 ETN97373.1 - 0.0057 16.7 1.0 1.2 9.2 0.2 2.7 2 1 0 2 2 2 1 Protein of unknown function (DUF627) ANAPC3 PF12895.7 ETN97373.1 - 0.0064 16.7 5.1 0.022 15.0 1.6 2.4 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 ETN97373.1 - 0.014 14.9 0.6 1.4 8.4 0.1 2.1 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like Sel1 PF08238.12 ETN97373.1 - 0.016 15.9 0.9 12 6.8 0.4 3.0 2 1 0 2 2 2 0 Sel1 repeat DUF2225 PF09986.9 ETN97373.1 - 0.017 14.9 1.9 0.088 12.5 1.9 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF5344 PF17279.2 ETN97373.1 - 0.027 15.0 2.3 1.3 9.6 0.5 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5344) HTH_Bact PF18768.1 ETN97373.1 - 0.054 13.1 1.1 18 5.0 0.1 3.3 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain DUF3856 PF12968.7 ETN97373.1 - 0.083 13.0 0.3 0.31 11.1 0.2 1.8 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) NSF PF02071.20 ETN97373.1 - 0.21 12.5 1.7 29 6.1 0.1 3.3 3 0 0 3 3 2 0 Aromatic-di-Alanine (AdAR) repeat MMS19_N PF14500.6 ETN97375.1 - 0.0015 18.2 0.3 0.004 16.8 0.3 2.0 1 1 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II COMMD1_N PF17221.3 ETN97375.1 - 0.14 12.5 3.1 0.08 13.2 0.7 1.7 2 0 0 2 2 2 0 COMMD1 N-terminal domain DUF1421 PF07223.11 ETN97375.1 - 0.22 11.4 0.1 0.22 11.4 0.1 2.0 2 0 0 2 2 2 0 UBA-like domain (DUF1421) G-alpha PF00503.20 ETN97376.1 - 4.2e-43 147.9 5.4 4.4e-43 147.8 5.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETN97376.1 - 3.7e-10 39.5 0.3 7.2e-10 38.6 0.3 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETN97376.1 - 0.0016 17.8 0.3 0.0019 17.6 0.3 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ETN97376.1 - 0.0031 17.0 0.1 0.005 16.3 0.1 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit CN_hydrolase PF00795.22 ETN97377.1 - 2.5e-27 95.9 0.0 3.8e-27 95.3 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase MSC PF09402.10 ETN97377.1 - 0.27 10.7 0.0 0.27 10.7 0.0 1.4 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain CENP-B_dimeris PF09026.10 ETN97378.1 - 0.076 13.4 4.0 0.11 12.9 4.0 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 ETN97378.1 - 5.6 6.2 14.7 7.1 5.8 14.7 1.1 1 0 0 1 1 1 0 NOA36 protein TPR_7 PF13176.6 ETN97379.1 - 0.011 15.7 0.0 1.7 8.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97379.1 - 0.1 12.9 0.0 19 5.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat zf-CCHC_3 PF13917.6 ETN97380.1 - 2.3 8.2 16.6 12 6.0 4.1 2.4 1 1 1 2 2 2 0 Zinc knuckle Adhesin_E PF16747.5 ETN97381.1 - 0.071 13.2 3.1 0.18 11.8 2.3 1.9 2 0 0 2 2 2 0 Surface-adhesin protein E UPF0240 PF06784.11 ETN97383.1 - 0.021 14.9 2.0 0.04 14.0 2.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) NPHI_C PF08469.10 ETN97383.1 - 0.055 13.4 0.5 0.073 13.0 0.5 1.3 1 0 0 1 1 1 0 Nucleoside triphosphatase I C-terminal Myb_DNA-bind_2 PF08914.11 ETN97383.1 - 0.11 12.7 1.4 0.57 10.4 0.2 2.5 2 1 1 3 3 3 0 Rap1 Myb domain AAA_24 PF13479.6 ETN97383.1 - 0.46 10.2 5.1 0.37 10.5 0.8 2.0 1 1 1 2 2 2 0 AAA domain Occludin_ELL PF07303.13 ETN97385.1 - 0.0023 18.6 1.3 0.0033 18.1 1.3 1.4 1 0 0 1 1 1 1 Occludin homology domain PUB PF09409.10 ETN97387.1 - 0.001 19.0 1.3 0.0081 16.1 1.3 2.2 1 1 0 1 1 1 1 PUB domain WD40 PF00400.32 ETN97388.1 - 6.3e-39 131.3 37.5 3.1e-06 27.8 0.2 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97388.1 - 1.3e-07 31.8 1.8 0.24 11.7 0.0 5.0 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97388.1 - 1.5e-07 30.4 12.8 0.075 11.7 0.3 5.5 3 3 1 5 5 5 4 Nucleoporin Nup120/160 DUF1539 PF07560.11 ETN97389.1 - 0.0085 16.2 0.9 0.013 15.6 0.2 1.7 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1539) PXA PF02194.15 ETN97389.1 - 0.022 14.8 1.1 0.026 14.5 1.1 1.1 1 0 0 1 1 1 0 PXA domain DDHD PF02862.17 ETN97389.1 - 0.025 14.7 6.0 0.031 14.4 6.0 1.2 1 0 0 1 1 1 0 DDHD domain Serinc PF03348.15 ETN97389.1 - 0.033 13.1 1.7 0.041 12.8 1.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNase_H2_suC PF08615.11 ETN97389.1 - 0.041 14.1 7.7 0.37 10.9 7.7 2.1 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Velvet PF11754.8 ETN97389.1 - 0.13 12.1 6.1 0.15 11.9 6.1 1.1 1 0 0 1 1 1 0 Velvet factor Folliculin PF11704.8 ETN97389.1 - 0.15 12.0 4.2 0.19 11.6 4.2 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Spt20 PF12090.8 ETN97389.1 - 0.54 9.8 16.7 0.83 9.2 16.7 1.3 1 0 0 1 1 1 0 Spt20 family Borrelia_P83 PF05262.11 ETN97389.1 - 0.57 8.6 11.0 0.59 8.6 11.0 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Adaptin_binding PF10199.9 ETN97389.1 - 0.71 10.5 19.3 0.93 10.1 19.3 1.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF913 PF06025.12 ETN97389.1 - 0.77 8.7 4.7 0.88 8.5 4.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 ETN97389.1 - 1.1 8.0 9.2 1.3 7.8 9.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 ETN97389.1 - 1.8 8.6 7.0 1.9 8.5 7.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Membralin PF09746.9 ETN97389.1 - 3.7 6.5 5.5 3.9 6.4 5.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein CLN3 PF02487.17 ETN97389.1 - 4.1 6.3 4.8 5.4 5.9 4.8 1.2 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 ETN97389.1 - 6.1 6.0 4.4 6.5 5.9 4.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DRIM PF07539.12 ETN97391.1 - 0.0059 15.0 1.5 0.0074 14.6 1.5 1.2 1 0 0 1 1 1 1 Down-regulated in metastasis WD40 PF00400.32 ETN97392.1 - 7.9e-19 67.7 9.9 3e-07 31.0 0.1 4.3 3 1 1 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN97392.1 - 0.00069 18.4 0.5 0.65 8.6 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97392.1 - 0.005 17.1 0.1 0.16 12.3 0.0 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETN97393.1 - 3.3e-27 94.2 14.6 8.2e-07 29.6 0.1 5.0 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97393.1 - 1.1e-08 35.3 0.3 0.036 14.3 0.0 4.1 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97393.1 - 1.8e-06 26.9 0.1 0.88 8.1 0.0 4.0 3 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN97393.1 - 5.5e-05 22.6 3.8 0.019 14.3 0.2 3.9 2 1 3 5 5 5 2 WD40-like domain DUF4807 PF16065.5 ETN97394.1 - 0.06 13.0 0.1 0.13 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4807) Intein_splicing PF14890.6 ETN97394.1 - 0.12 12.3 3.5 0.25 11.3 3.5 1.5 1 0 0 1 1 1 0 Intein splicing domain SUB1_ProdP9 PF18213.1 ETN97395.1 - 0.037 13.9 1.0 0.15 12.0 1.0 2.0 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 Tai4 PF16695.5 ETN97396.1 - 0.0057 17.2 0.0 0.0096 16.4 0.0 1.3 1 0 0 1 1 1 1 Type VI secretion system (T6SS), amidase immunity protein Cys_rich_VLP PF14194.6 ETN97396.1 - 0.029 14.5 0.8 0.048 13.8 0.5 1.5 1 1 0 1 1 1 0 Cysteine-rich VLP MRP-S33 PF08293.11 ETN97396.1 - 0.033 14.4 0.1 0.054 13.7 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 ETRAMP PF09716.10 ETN97397.1 - 8.8 6.5 9.2 1.4e+02 2.7 9.2 2.1 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) NACHT PF05729.12 ETN97398.1 - 8.9e-05 22.5 0.0 0.00013 22.0 0.0 1.2 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETN97398.1 - 0.022 14.0 0.0 0.025 13.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Torsin PF06309.11 ETN97398.1 - 0.024 14.7 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Torsin Condensin2nSMC PF12422.8 ETN97399.1 - 0.04 14.1 0.4 0.079 13.1 0.1 1.6 2 0 0 2 2 2 0 Condensin II non structural maintenance of chromosomes subunit CAP_GLY PF01302.25 ETN97400.1 - 1e-36 124.8 8.2 2.4e-16 59.5 0.3 3.1 3 0 0 3 3 3 3 CAP-Gly domain YajC PF02699.15 ETN97400.1 - 0.091 12.6 2.5 4.3 7.3 0.9 2.7 2 1 0 2 2 2 0 Preprotein translocase subunit CENP-B_dimeris PF09026.10 ETN97401.1 - 0.024 15.0 6.7 0.036 14.4 6.7 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain MRNIP PF15749.5 ETN97401.1 - 0.13 13.0 2.5 0.17 12.6 2.5 1.1 1 0 0 1 1 1 0 MRN-interacting protein NOA36 PF06524.12 ETN97401.1 - 0.36 10.1 7.1 0.42 9.9 7.1 1.1 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 ETN97401.1 - 3.1 6.9 6.3 3.2 6.9 6.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETN97402.1 - 8.7e-06 26.4 3.1 0.00073 20.3 0.6 3.1 2 2 0 2 2 2 2 WD domain, G-beta repeat DUF2798 PF11391.8 ETN97403.1 - 7.5 6.7 22.6 2.2 8.4 3.0 3.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2798) zf-TRAF PF02176.18 ETN97404.1 - 0.006 17.3 5.4 0.006 17.3 5.4 3.4 2 1 1 3 3 3 1 TRAF-type zinc finger TPR_12 PF13424.6 ETN97405.1 - 4.3e-157 510.7 25.6 6.3e-23 80.9 0.1 6.7 1 1 8 9 9 9 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97405.1 - 2.6e-97 316.4 0.1 2.8e-12 46.1 0.0 9.1 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97405.1 - 4.3e-68 222.6 59.3 1.4e-09 37.3 0.9 9.7 9 1 1 10 10 10 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97405.1 - 4.9e-68 220.3 14.5 1.8e-08 33.8 0.0 9.2 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97405.1 - 1.6e-58 190.1 60.5 5e-08 32.6 0.8 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97405.1 - 8.6e-57 184.8 40.1 1.1e-07 31.3 1.4 9.9 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97405.1 - 8.2e-36 122.4 0.0 0.00038 21.0 0.0 8.9 6 1 3 9 9 9 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97405.1 - 2.5e-35 118.3 17.8 0.00023 21.3 0.2 10.2 9 2 0 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97405.1 - 1.1e-24 85.0 0.0 0.29 12.1 0.0 8.6 5 2 4 9 9 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97405.1 - 6.8e-20 70.5 61.2 0.00058 19.5 3.5 12.2 6 3 4 10 10 10 7 TPR repeat TPR_6 PF13174.6 ETN97405.1 - 2.1e-19 68.8 11.2 0.069 13.8 0.1 9.3 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN97405.1 - 1.7e-17 63.8 0.0 1.5e-07 31.2 0.0 3.3 1 1 2 3 3 3 3 MalT-like TPR region SNAP PF14938.6 ETN97405.1 - 1.8e-16 60.4 10.5 1.7e-06 27.6 1.3 4.1 1 1 3 4 4 4 4 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETN97405.1 - 7.4e-14 50.9 27.3 0.23 11.8 0.1 9.4 9 0 0 9 9 9 4 PPR repeat DUF5113 PF17140.4 ETN97405.1 - 7.3e-13 48.6 29.4 0.081 12.7 0.1 8.7 7 2 2 9 9 9 5 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETN97405.1 - 3.6e-12 46.3 16.6 0.038 14.2 0.1 6.3 3 2 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETN97405.1 - 9e-12 44.7 38.7 0.00083 19.3 0.8 9.4 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97405.1 - 3.8e-11 43.3 4.4 0.26 11.8 0.0 6.0 3 2 3 7 7 7 5 Tetratricopeptide repeat RPN7 PF10602.9 ETN97405.1 - 1.3e-08 34.7 20.6 0.11 12.3 0.2 7.1 2 2 5 7 7 7 2 26S proteasome subunit RPN7 MIT PF04212.18 ETN97405.1 - 6.5e-08 32.5 46.0 0.13 12.4 0.3 8.6 9 0 0 9 9 8 5 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETN97405.1 - 9e-07 28.3 9.8 8.6 5.9 0.0 9.1 11 0 0 11 11 11 0 SHNi-TPR TPR_9 PF13371.6 ETN97405.1 - 9e-05 22.5 0.0 7.5 6.8 0.0 4.9 2 1 3 6 6 6 0 Tetratricopeptide repeat DUF4810 PF16068.5 ETN97405.1 - 0.00011 22.7 16.9 3.9 8.1 0.2 6.6 6 1 0 6 6 6 1 Domain of unknown function (DUF4810) HisG PF01634.18 ETN97405.1 - 0.00021 21.3 2.8 3.8 7.5 0.1 5.1 1 1 3 5 5 5 1 ATP phosphoribosyltransferase TPR_21 PF09976.9 ETN97405.1 - 0.00026 20.7 16.3 0.00075 19.3 0.3 5.8 3 2 4 7 7 7 1 Tetratricopeptide repeat-like domain BTAD PF03704.17 ETN97405.1 - 0.001 19.5 0.0 3.5 8.0 0.0 3.6 4 1 0 4 4 3 1 Bacterial transcriptional activator domain TPR_15 PF13429.6 ETN97405.1 - 0.0026 17.0 0.2 24 4.0 0.0 4.6 4 2 0 5 5 5 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETN97405.1 - 0.0029 17.7 6.6 6.7 6.8 0.2 5.3 1 1 2 4 4 4 0 Domain of Unknown Function (DUF3856) FATC PF02260.20 ETN97405.1 - 0.0056 16.5 5.9 53 3.8 0.1 5.8 7 0 0 7 7 6 0 FATC domain UBA_6 PF18039.1 ETN97405.1 - 0.028 14.3 0.1 14 5.7 0.0 4.9 7 0 0 7 7 5 0 UBA-like domain Mob_Pre PF01076.19 ETN97405.1 - 0.031 14.1 17.0 0.56 10.0 0.2 4.6 2 1 2 5 5 5 0 Plasmid recombination enzyme Musclin PF11037.8 ETN97405.1 - 0.13 12.2 0.0 49 3.8 0.0 4.1 6 0 0 6 6 5 0 Insulin-resistance promoting peptide in skeletal muscle DUF2777 PF10949.8 ETN97405.1 - 0.17 11.5 3.4 31 4.2 0.0 4.4 3 1 2 5 5 5 0 Protein of unknown function (DUF2777) Sel1 PF08238.12 ETN97405.1 - 0.25 12.1 27.3 27 5.6 0.0 9.9 9 3 0 9 9 9 0 Sel1 repeat Pep3_Vps18 PF05131.14 ETN97405.1 - 0.42 10.4 9.3 54 3.6 0.0 6.0 7 0 0 7 7 7 0 Pep3/Vps18/deep orange family DUF916 PF06030.12 ETN97405.1 - 0.72 9.9 4.5 4.9 7.3 0.0 3.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF916) PG_binding_2 PF08823.11 ETN97405.1 - 0.75 10.1 6.7 2.8 8.3 0.1 4.2 4 2 1 5 5 3 0 Putative peptidoglycan binding domain DUF627 PF04781.12 ETN97405.1 - 0.93 9.5 13.5 6.3 6.9 0.9 5.5 4 2 1 5 5 4 0 Protein of unknown function (DUF627) Rota_NSP3 PF01665.16 ETN97405.1 - 1.5 7.9 9.5 21 4.1 0.2 4.5 2 2 2 5 5 5 0 Rotavirus non-structural protein NSP3 SPO22 PF08631.10 ETN97405.1 - 1.6 8.2 13.4 21 4.4 0.0 5.3 2 1 1 6 6 6 0 Meiosis protein SPO22/ZIP4 like PPR_2 PF13041.6 ETN97405.1 - 3.1 8.0 22.2 67 3.8 0.1 8.0 9 0 0 9 9 8 0 PPR repeat family SLT PF01464.20 ETN97405.1 - 4.3 7.0 14.5 25 4.6 0.1 5.8 2 2 5 7 7 7 0 Transglycosylase SLT domain Clathrin PF00637.20 ETN97405.1 - 6.3 6.7 19.5 31 4.4 0.1 6.7 3 1 2 7 7 7 0 Region in Clathrin and VPS DUF3627 PF12299.8 ETN97405.1 - 8.8 6.5 18.2 8.3 6.6 0.2 5.6 4 2 3 7 7 6 0 Protein of unknown function (DUF3627) DDE_3 PF13358.6 ETN97406.1 - 6.2e-19 68.2 0.2 1.1e-18 67.4 0.2 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 ETN97406.1 - 9.6e-14 51.4 8.1 9.6e-14 51.4 8.1 2.5 2 1 1 3 3 3 1 Transposase HTH_38 PF13936.6 ETN97406.1 - 6e-08 32.3 0.0 2.1e-07 30.6 0.0 2.0 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_Tnp_Tc3_1 PF11427.8 ETN97406.1 - 0.00088 19.1 0.2 0.0022 17.8 0.1 1.8 2 0 0 2 2 2 1 Tc3 transposase Succ_DH_flav_C PF02910.20 ETN97406.1 - 0.004 17.1 0.4 0.0085 16.1 0.4 1.6 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term HTH_30 PF13556.6 ETN97406.1 - 0.0064 16.3 1.9 0.031 14.1 0.0 2.6 2 1 1 3 3 3 1 PucR C-terminal helix-turn-helix domain HTH_29 PF13551.6 ETN97406.1 - 0.0079 16.2 1.4 0.011 15.8 0.3 1.7 2 0 0 2 2 2 1 Winged helix-turn helix HTH_23 PF13384.6 ETN97406.1 - 0.011 15.6 0.3 0.051 13.4 0.3 2.2 1 0 0 1 1 1 0 Homeodomain-like domain Sigma70_r4_2 PF08281.12 ETN97406.1 - 0.012 15.3 1.2 0.067 12.9 0.3 2.3 2 0 0 2 2 2 0 Sigma-70, region 4 HTH_32 PF13565.6 ETN97406.1 - 0.017 15.7 9.5 0.079 13.6 3.8 2.7 1 1 1 2 2 2 0 Homeodomain-like domain MarR_2 PF12802.7 ETN97406.1 - 0.049 13.5 0.4 0.049 13.5 0.4 2.3 1 1 1 2 2 2 0 MarR family MarR PF01047.22 ETN97406.1 - 0.16 11.9 0.0 0.16 11.9 0.0 2.6 3 0 0 3 3 3 0 MarR family RGS PF00615.19 ETN97407.1 - 0.0043 17.3 0.3 0.005 17.1 0.3 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain MSC PF09402.10 ETN97409.1 - 0.0034 16.9 0.9 0.026 14.0 0.2 2.1 2 0 0 2 2 2 1 Man1-Src1p-C-terminal domain CrgA PF06781.12 ETN97409.1 - 0.097 12.7 0.2 0.16 12.0 0.2 1.3 1 0 0 1 1 1 0 Cell division protein CrgA Exo_endo_phos_2 PF14529.6 ETN97410.1 - 1.5e-11 44.1 0.9 1.5e-11 44.1 0.9 2.1 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase TPR_12 PF13424.6 ETN97411.1 - 9.7e-25 86.7 0.1 2.3e-17 63.0 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97411.1 - 5.2e-23 80.2 0.1 1.5e-08 34.2 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97411.1 - 1.3e-22 78.6 11.5 1.1e-09 37.7 0.5 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97411.1 - 1.1e-21 75.2 0.6 7.7e-09 35.0 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97411.1 - 5.2e-19 66.8 15.1 7e-09 35.2 0.6 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97411.1 - 1.7e-17 62.0 5.2 1.5e-07 31.0 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97411.1 - 1.1e-07 31.7 5.3 0.017 15.5 0.0 4.0 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97411.1 - 2.1e-06 28.1 0.0 0.82 10.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97411.1 - 2e-05 24.9 0.1 0.61 10.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97411.1 - 0.00014 21.7 6.2 0.31 10.8 0.4 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETN97411.1 - 0.00046 20.8 0.0 0.5 11.1 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97411.1 - 0.00082 19.0 11.5 0.0098 15.6 0.2 4.0 3 2 0 3 3 3 1 TPR repeat TPR_3 PF07720.12 ETN97411.1 - 0.0016 18.4 3.7 7.4 6.7 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETN97411.1 - 0.0022 18.0 3.9 4.3 7.5 0.2 3.1 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF4810 PF16068.5 ETN97411.1 - 0.018 15.6 0.4 8.4 7.0 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4810) SNAP PF14938.6 ETN97411.1 - 0.025 14.0 0.5 0.056 12.9 0.1 1.7 2 0 0 2 2 2 0 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETN97411.1 - 0.029 14.6 5.2 0.38 11.1 0.1 3.0 3 0 0 3 3 3 0 PPR repeat DUF5475 PF17569.2 ETN97411.1 - 0.031 14.6 0.1 13 6.2 0.0 2.9 1 1 1 3 3 3 0 Family of unknown function (DUF5475) ATP-synt_E_2 PF08112.11 ETN97411.1 - 0.055 13.7 7.9 0.46 10.8 0.5 3.1 3 0 0 3 3 3 0 ATP synthase epsilon subunit TPR_MalT PF17874.1 ETN97411.1 - 0.063 12.6 0.0 0.074 12.4 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region ACP PF06857.11 ETN97412.1 - 0.039 14.2 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Malonate decarboxylase delta subunit (MdcD) HEAT PF02985.22 ETN97413.1 - 1.2e-09 37.6 0.1 0.0024 18.0 0.0 4.2 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ETN97413.1 - 1.6e-09 38.0 0.0 4.8e-07 30.1 0.0 2.7 2 1 1 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ETN97413.1 - 1e-05 26.0 0.1 0.33 11.6 0.1 2.9 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETN97413.1 - 3e-05 23.9 2.1 0.088 12.6 0.1 3.2 1 1 2 3 3 3 2 TATA-binding protein interacting (TIP20) RTP1_C1 PF10363.9 ETN97413.1 - 3.4e-05 24.0 1.1 0.12 12.5 0.1 3.3 1 1 2 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETN97413.1 - 0.00046 20.3 4.9 0.0021 18.1 2.0 2.9 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 ETN97413.1 - 0.0033 16.6 0.3 0.45 9.6 0.0 2.6 2 1 1 3 3 3 1 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 ETN97413.1 - 0.0057 17.1 0.0 6.5 7.4 0.0 3.0 3 0 0 3 3 3 1 HEAT-like repeat U3snoRNP10 PF12397.8 ETN97413.1 - 0.016 15.5 0.0 5.2 7.4 0.0 2.8 2 1 0 2 2 2 0 U3 small nucleolar RNA-associated protein 10 NLE PF08154.12 ETN97413.1 - 0.017 15.7 8.8 2.9 8.5 0.2 4.8 2 1 2 5 5 5 0 NLE (NUC135) domain Spore_Cse60 PF10957.8 ETN97413.1 - 0.14 12.2 3.9 9.3 6.4 0.2 3.4 2 1 1 3 3 3 0 Sporulation protein Cse60 RNA_binding PF01877.17 ETN97413.1 - 1 9.7 9.6 1.5 9.1 0.4 3.8 2 1 3 5 5 5 0 RNA binding Kelch_4 PF13418.6 ETN97414.1 - 0.00023 21.1 0.1 0.009 16.0 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN97414.1 - 0.00038 20.6 2.6 0.023 15.0 0.0 4.1 4 1 1 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETN97414.1 - 0.045 14.1 0.1 0.62 10.4 0.0 2.8 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN97414.1 - 0.062 12.9 1.5 0.1 12.2 0.1 2.2 3 0 0 3 3 3 0 Kelch motif DUF1154 PF06631.11 ETN97414.1 - 0.25 11.4 3.7 0.21 11.6 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1154) RICTOR_N PF14664.6 ETN97415.1 - 0.05 12.6 1.7 2.3 7.1 0.1 2.1 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term SET PF00856.28 ETN97416.1 - 5.6e-10 39.9 0.5 5.6e-10 39.9 0.5 1.9 2 1 0 2 2 2 1 SET domain DUF2852 PF11014.8 ETN97416.1 - 0.6 10.3 5.0 5.4 7.2 2.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2852) IMUP PF15761.5 ETN97416.1 - 0.98 10.1 5.7 2.2 9.0 5.7 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 ETN97416.1 - 2.3 7.8 12.5 5 6.7 12.5 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ubiquitin PF00240.23 ETN97417.1 - 2.5e-120 392.3 14.6 3.2e-33 113.3 0.4 4.0 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 ETN97417.1 - 1.1e-59 198.1 13.5 2.9e-16 59.0 0.5 4.0 4 0 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETN97417.1 - 8.5e-21 74.2 6.6 0.00013 22.4 0.1 5.6 4 4 0 4 4 4 3 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETN97417.1 - 1.8e-16 60.2 0.9 0.022 14.8 0.0 4.8 4 3 0 4 4 4 4 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETN97417.1 - 1.4e-14 53.7 6.3 0.0061 16.5 0.1 4.2 4 0 0 4 4 4 3 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ETN97417.1 - 1.7e-14 53.9 3.3 0.031 14.6 0.1 4.1 4 0 0 4 4 4 4 Ubiquitin-like domain DUF2407 PF10302.9 ETN97417.1 - 9.4e-13 48.6 0.9 0.15 12.6 0.0 4.2 1 1 3 4 4 4 3 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETN97417.1 - 1.2e-09 38.0 11.1 11 6.1 0.1 7.0 7 0 0 7 7 7 0 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ETN97417.1 - 1.1e-06 28.6 0.1 2.7 7.8 0.0 3.9 4 0 0 4 4 4 3 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 ETN97417.1 - 2.5e-06 27.8 0.8 25 5.3 0.0 5.3 4 3 3 7 7 7 0 Protein of unknown function (DUF2870) PI3K_rbd PF00794.18 ETN97417.1 - 1e-05 25.6 1.1 4.2 7.6 0.0 3.4 3 0 0 3 3 3 3 PI3-kinase family, ras-binding domain eRF1_1 PF03463.15 ETN97417.1 - 0.00015 21.7 0.5 10 6.2 0.0 3.4 3 0 0 3 3 3 0 eRF1 domain 1 DUF3379 PF11859.8 ETN97417.1 - 0.00063 19.1 0.2 12 5.2 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF3379) RBD PF02196.15 ETN97417.1 - 0.00085 19.4 0.0 23 5.1 0.0 3.4 3 0 0 3 3 3 0 Raf-like Ras-binding domain DUF969 PF06149.12 ETN97417.1 - 0.0019 17.7 0.1 26 4.2 0.0 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF969) DUF4454 PF14628.6 ETN97417.1 - 0.0027 17.6 0.1 22 4.8 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4454) Polysacc_deac_3 PF15421.6 ETN97417.1 - 0.02 13.4 0.3 27 3.1 0.0 3.0 1 1 0 3 3 3 0 Putative polysaccharide deacetylase ProRS-C_2 PF09181.10 ETN97417.1 - 0.047 13.8 1.5 68 3.7 0.0 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal DUF5383 PF17355.2 ETN97417.1 - 0.053 13.9 7.0 30 5.0 0.1 3.8 4 0 0 4 4 4 0 Family of unknown function (DUF5383) DUF3861 PF12977.7 ETN97417.1 - 0.054 13.7 0.3 98 3.2 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) FlgD_ig PF13860.6 ETN97417.1 - 0.085 12.7 2.9 60 3.6 0.1 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain PI3K_p85B PF02192.16 ETN97417.1 - 0.17 11.6 3.3 56 3.6 0.1 3.4 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain LBP_C PF17386.2 ETN97417.1 - 0.18 11.7 0.7 1.3e+02 2.6 0.0 3.2 3 0 0 3 3 3 0 Lacto-N-biose phosphorylase C-terminal domain Phage_sheath_1N PF17481.2 ETN97417.1 - 0.2 12.1 1.9 32 5.1 0.3 3.0 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain DMA PF03474.14 ETN97417.1 - 0.29 10.8 4.3 1.4e+02 2.2 0.0 4.1 4 0 0 4 4 4 0 DMRTA motif DUF2207 PF09972.9 ETN97418.1 - 6.8e-05 21.8 3.1 9e-05 21.4 3.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4272 PF14094.6 ETN97419.1 - 0.021 14.0 0.0 0.039 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) PsbQ PF05757.11 ETN97419.1 - 0.12 12.1 0.1 0.33 10.7 0.1 1.6 2 0 0 2 2 2 0 Oxygen evolving enhancer protein 3 (PsbQ) UCH PF00443.29 ETN97421.1 - 0.0021 17.6 0.1 0.0021 17.6 0.1 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase CsgE PF10627.9 ETN97421.1 - 0.12 12.6 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Curli assembly protein CsgE Nudix_N_2 PF14803.6 ETN97421.1 - 0.15 12.0 0.1 0.15 12.0 0.1 2.0 2 0 0 2 2 2 0 Nudix N-terminal CDC45 PF02724.14 ETN97421.1 - 0.28 9.5 2.7 0.37 9.0 2.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TPR_12 PF13424.6 ETN97422.1 - 3e-18 65.9 0.9 1.5e-08 34.8 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97422.1 - 6.8e-15 54.0 16.6 9.7e-07 28.5 0.8 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97422.1 - 4.2e-13 48.3 11.8 1.1e-05 25.1 1.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97422.1 - 2.1e-12 46.3 19.4 1.3e-06 28.0 1.5 4.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97422.1 - 2.3e-12 46.0 1.1 4.7e-05 23.1 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97422.1 - 9.7e-12 44.4 0.4 6e-05 22.8 0.2 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETN97422.1 - 1.8e-06 27.9 10.9 0.1 12.7 0.2 4.3 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETN97422.1 - 3.2e-05 23.8 2.2 9.2e-05 22.3 0.7 2.2 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETN97422.1 - 0.00045 19.8 11.3 0.053 13.2 0.8 3.5 3 1 1 4 4 4 2 TPR repeat TPR_14 PF13428.6 ETN97422.1 - 0.00062 20.4 0.1 0.84 10.6 0.0 3.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97422.1 - 0.0015 18.7 1.7 2.6 8.6 0.0 3.1 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97422.1 - 0.0045 17.6 0.0 3.8 8.2 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97422.1 - 0.0053 17.3 4.9 2.3 9.0 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETN97422.1 - 0.27 11.3 2.6 7.9 6.6 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97423.1 - 1.4e-71 236.8 23.2 2.4e-19 69.4 0.5 4.5 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97423.1 - 1.4e-47 158.3 0.8 4.9e-09 35.8 0.0 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97423.1 - 7.5e-35 117.3 36.0 3.3e-09 36.2 1.2 5.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97423.1 - 9.6e-34 112.9 12.7 6.1e-07 29.0 0.1 5.4 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97423.1 - 3e-30 101.8 28.0 6.4e-08 32.1 0.6 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97423.1 - 1.4e-20 71.7 35.4 2.1e-05 24.4 1.9 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97423.1 - 7.3e-18 64.0 27.9 6.5e-06 25.7 1.2 6.1 5 1 1 6 6 6 4 TPR repeat TPR_6 PF13174.6 ETN97423.1 - 4.7e-14 52.0 6.4 0.012 16.2 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97423.1 - 6.6e-14 52.3 0.1 0.0013 19.4 0.0 4.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97423.1 - 6.2e-13 48.2 3.7 0.39 11.2 0.0 6.0 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97423.1 - 2e-10 40.6 0.5 0.43 11.5 0.1 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN97423.1 - 3.7e-09 36.4 0.0 1.1e-05 25.0 0.0 2.0 1 1 1 2 2 2 2 MalT-like TPR region DUF5113 PF17140.4 ETN97423.1 - 4.9e-07 29.7 11.7 0.19 11.5 0.1 4.8 3 1 1 5 5 5 2 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETN97423.1 - 1.7e-06 28.1 9.2 0.0025 18.0 1.7 3.5 1 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ETN97423.1 - 1.7e-06 27.9 10.0 0.75 10.2 0.1 5.3 5 0 0 5 5 5 2 PPR repeat TPR_19 PF14559.6 ETN97423.1 - 5.8e-06 26.7 0.8 0.091 13.3 0.2 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat Med9 PF07544.13 ETN97423.1 - 0.00018 21.5 0.1 8.1 6.6 0.0 3.4 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 ATP-synt_E_2 PF08112.11 ETN97423.1 - 0.00036 20.7 25.9 0.43 10.9 0.6 5.9 6 0 0 6 6 6 2 ATP synthase epsilon subunit DUF4298 PF14131.6 ETN97423.1 - 0.00041 20.3 17.3 0.0066 16.4 1.5 3.4 2 2 1 3 3 3 1 Domain of unknown function (DUF4298) DUF4810 PF16068.5 ETN97423.1 - 0.00083 19.8 1.4 3.9 8.1 0.2 3.8 2 2 2 4 4 4 1 Domain of unknown function (DUF4810) DUF4320 PF14208.6 ETN97423.1 - 0.001 19.1 0.0 0.88 9.7 0.0 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4320) TPR_9 PF13371.6 ETN97423.1 - 0.0059 16.7 0.1 0.34 11.1 0.0 3.0 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETN97423.1 - 0.0088 15.8 5.3 0.91 9.2 0.1 3.5 2 2 1 3 3 3 1 Tetratricopeptide repeat-like domain HpaP PF09483.10 ETN97423.1 - 0.0095 16.2 0.2 0.32 11.3 0.0 2.8 3 1 1 4 4 2 1 Type III secretion protein (HpaP) Mob_Pre PF01076.19 ETN97423.1 - 0.012 15.4 4.1 0.19 11.5 1.9 2.3 2 1 0 2 2 2 0 Plasmid recombination enzyme Ubiq-assoc PF09145.10 ETN97423.1 - 0.029 14.4 14.4 12 6.0 0.1 5.9 5 0 0 5 5 5 0 Ubiquitin-associated OrfA PF17495.2 ETN97423.1 - 0.036 14.2 0.3 47 4.2 0.0 3.6 1 1 2 4 4 4 0 Vpr-like OrfA SHNi-TPR PF10516.9 ETN97423.1 - 0.047 13.2 2.6 12 5.4 0.0 4.3 5 0 0 5 5 5 0 SHNi-TPR DUF3416 PF11896.8 ETN97423.1 - 0.07 13.4 0.1 0.29 11.4 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3416) DUF3775 PF12616.8 ETN97423.1 - 0.074 13.1 1.7 11 6.2 0.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3775) Thg1 PF04446.12 ETN97423.1 - 0.076 13.1 0.2 1 9.4 0.0 2.1 1 1 1 2 2 2 0 tRNAHis guanylyltransferase HTH_Bact PF18768.1 ETN97423.1 - 0.11 12.1 15.0 17 5.1 2.3 6.3 3 3 2 5 5 5 0 Helix-turn-helix bacterial domain TssN PF17555.2 ETN97423.1 - 0.11 11.9 4.0 4.4 6.6 0.0 2.6 3 0 0 3 3 3 0 Type VI secretion system, TssN Rapsyn_N PF10579.9 ETN97423.1 - 0.14 12.3 8.4 1.3 9.2 0.3 3.6 2 2 2 4 4 4 0 Rapsyn N-terminal myristoylation and linker region M60-like_N PF17291.2 ETN97423.1 - 0.15 11.9 0.2 25 4.8 0.0 2.5 2 0 0 2 2 2 0 N-terminal domain of M60-like peptidases NSF PF02071.20 ETN97423.1 - 0.2 12.5 10.1 76 4.8 0.1 5.4 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat DUF3836 PF12930.7 ETN97423.1 - 0.2 11.4 11.3 0.052 13.3 2.3 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF3836) SPAN-X PF07458.12 ETN97423.1 - 0.22 12.0 6.8 70 4.0 0.0 4.7 4 1 1 5 5 4 0 Sperm protein associated with nucleus, mapped to X chromosome bPH_3 PF14470.6 ETN97423.1 - 1.7 9.0 9.0 3.5 8.0 0.2 3.8 2 1 2 4 4 4 0 Bacterial PH domain SPO22 PF08631.10 ETN97423.1 - 2.4 7.6 15.6 3 7.2 0.2 3.7 3 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETN97423.1 - 2.7 8.1 18.6 3.8 7.6 0.2 4.9 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Tmpp129 PF10272.9 ETN97424.1 - 0.0069 15.7 0.6 0.011 15.0 0.6 1.2 1 0 0 1 1 1 1 Putative transmembrane protein precursor HTH_Tnp_Tc3_2 PF01498.18 ETN97425.1 - 6.5e-12 45.5 0.9 8.7e-12 45.1 0.9 1.2 1 0 0 1 1 1 1 Transposase HTH_21 PF13276.6 ETN97425.1 - 0.001 19.2 0.0 0.0017 18.5 0.0 1.4 1 0 0 1 1 1 1 HTH-like domain Sun2_CC2 PF18580.1 ETN97425.1 - 0.052 13.8 0.1 0.088 13.0 0.1 1.4 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 Intein_splicing PF14890.6 ETN97425.1 - 0.074 13.0 1.4 0.085 12.8 1.4 1.1 1 0 0 1 1 1 0 Intein splicing domain LacI PF00356.21 ETN97425.1 - 0.094 12.5 0.3 0.15 11.9 0.3 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Syntaxin_2 PF14523.6 ETN97426.1 - 0.0024 18.2 2.2 0.0024 18.2 2.2 1.7 1 1 0 1 1 1 1 Syntaxin-like protein TPR_8 PF13181.6 ETN97426.1 - 0.77 10.1 0.2 0.77 10.1 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97429.1 - 3.7e-38 129.7 5.1 4.3e-18 65.4 0.1 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97429.1 - 1.1e-19 69.7 0.1 1.3e-08 34.4 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97429.1 - 1.6e-18 65.3 0.4 1.3e-09 37.4 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97429.1 - 8.9e-15 53.8 14.8 5.8e-09 35.4 1.0 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97429.1 - 7.5e-12 44.5 12.7 1.5e-07 31.1 1.6 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97429.1 - 1.9e-11 43.2 7.2 6.1e-07 29.1 0.3 3.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97429.1 - 2.6e-06 27.4 6.1 0.0067 16.7 0.2 4.2 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97429.1 - 1.7e-05 25.1 0.1 0.18 12.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97429.1 - 5.5e-05 23.7 0.0 0.17 12.5 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 ETN97429.1 - 0.00013 21.9 1.9 0.22 11.6 0.2 2.8 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETN97429.1 - 0.00025 20.5 0.0 0.0003 20.3 0.0 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_3 PF07720.12 ETN97429.1 - 0.00049 20.0 3.8 0.41 10.7 0.3 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97429.1 - 0.00058 19.5 13.7 0.13 12.0 0.7 4.8 3 2 2 5 5 5 4 TPR repeat DUF5113 PF17140.4 ETN97429.1 - 0.0019 18.0 0.2 0.69 9.7 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF5113) PPR PF01535.20 ETN97429.1 - 0.0025 17.9 0.6 0.12 12.7 0.1 2.6 2 0 0 2 2 2 1 PPR repeat TPR_14 PF13428.6 ETN97429.1 - 0.0027 18.4 0.0 1.9 9.5 0.0 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat Sel1 PF08238.12 ETN97429.1 - 0.026 15.2 2.6 19 6.1 0.5 4.0 3 2 0 3 3 3 0 Sel1 repeat BING4CT PF08149.11 ETN97429.1 - 0.079 12.8 0.0 1.2 8.9 0.0 2.2 2 0 0 2 2 2 0 BING4CT (NUC141) domain ATP-synt_E_2 PF08112.11 ETN97429.1 - 0.18 12.1 4.8 2.9 8.2 4.8 2.5 1 1 0 1 1 1 0 ATP synthase epsilon subunit DUF4378 PF14309.6 ETN97430.1 - 0.027 14.8 0.4 0.035 14.5 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) BAP PF06639.11 ETN97430.1 - 0.21 12.0 1.9 3.2 8.1 0.2 2.2 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) CAP_GLY PF01302.25 ETN97431.1 - 0.0074 16.3 0.6 9 6.4 0.0 3.2 3 1 1 4 4 4 2 CAP-Gly domain TAFII55_N PF04658.13 ETN97432.1 - 2.7e-22 79.2 0.0 4e-22 78.6 0.0 1.3 1 0 0 1 1 1 1 TAFII55 protein conserved region Arc PF03869.14 ETN97432.1 - 0.02 14.7 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 Arc-like DNA binding domain ETRAMP PF09716.10 ETN97433.1 - 0.86 9.7 3.4 8.9 6.5 0.1 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF5444 PF17519.2 ETN97434.1 - 0.013 15.5 0.1 0.031 14.3 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5444) DpnI_C PF17726.1 ETN97434.1 - 0.7 10.1 4.2 1.3 9.2 0.2 3.1 3 0 0 3 3 3 0 Dam-replacing HTH domain CAP_GLY PF01302.25 ETN97436.1 - 3.7e-07 30.1 0.0 6.6e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain TetR_C_12 PF16914.5 ETN97436.1 - 0.21 11.8 0.6 2 8.6 0.0 2.5 2 1 1 3 3 3 0 Bacterial transcriptional repressor C-terminal Transket_pyr PF02779.24 ETN97437.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 Transketolase, pyrimidine binding domain Utp14 PF04615.13 ETN97439.1 - 0.74 8.3 30.3 0.85 8.1 30.3 1.0 1 0 0 1 1 1 0 Utp14 protein CCDC71L PF15374.6 ETN97440.1 - 7.1 5.8 25.6 11 5.2 25.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L zf-TRAF PF02176.18 ETN97443.1 - 2.5e-05 24.9 3.7 2.5e-05 24.9 3.7 3.1 3 1 0 3 3 3 1 TRAF-type zinc finger zf-RVT PF13966.6 ETN97443.1 - 0.12 13.1 6.3 0.15 12.8 0.1 3.0 3 1 0 3 3 3 0 zinc-binding in reverse transcriptase T2SS_PulS_OutS PF09691.10 ETN97444.1 - 1.9 8.7 5.1 3.3 7.9 0.0 3.3 5 0 0 5 5 5 0 Type II secretion system pilotin lipoprotein (PulS_OutS) CAP_GLY PF01302.25 ETN97445.1 - 0.0026 17.7 0.0 0.0054 16.7 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain RTX_C PF08339.10 ETN97445.1 - 0.033 14.3 0.1 0.06 13.4 0.1 1.4 1 0 0 1 1 1 0 RTX C-terminal domain CitMHS PF03600.16 ETN97448.1 - 0.12 11.6 3.5 0.12 11.5 0.7 1.9 1 1 1 2 2 2 0 Citrate transporter Tmemb_9 PF05434.11 ETN97448.1 - 2.5 8.0 10.3 0.22 11.4 2.4 3.1 3 0 0 3 3 3 0 TMEM9 DUF2427 PF10348.9 ETN97450.1 - 0.048 13.5 3.3 7 6.5 0.1 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF2427) Clostridium_P47 PF06597.11 ETN97450.1 - 0.057 12.1 0.1 0.077 11.7 0.1 1.1 1 0 0 1 1 1 0 Clostridium P-47 protein WD40 PF00400.32 ETN97451.1 - 2.3e-22 78.8 0.4 4.7e-11 43.1 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97451.1 - 5.1e-07 29.9 0.0 0.00028 21.1 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97451.1 - 0.00023 20.6 0.0 0.0004 19.8 0.0 1.4 1 1 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETN97451.1 - 0.0016 17.5 0.0 0.19 10.6 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN97451.1 - 0.0087 16.0 0.2 6.9 6.7 0.0 2.6 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETN97451.1 - 0.16 11.7 0.2 24 4.7 0.0 2.5 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature AvrM-A PF18241.1 ETN97452.1 - 0.043 14.2 0.8 0.049 14.0 0.8 1.2 1 0 0 1 1 1 0 Flax-rust effector AvrM-A EF-hand_6 PF13405.6 ETN97452.1 - 0.073 13.0 2.2 0.33 11.0 2.2 2.2 1 1 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 ETN97452.1 - 0.075 12.6 1.6 0.075 12.6 1.6 2.2 2 0 0 2 2 2 0 EF hand EF-hand_1 PF00036.32 ETN97452.1 - 0.13 11.8 3.8 0.16 11.6 1.6 2.3 2 1 0 2 2 2 0 EF hand Nab1 PF04902.12 ETN97453.1 - 0.024 15.1 0.5 0.026 14.9 0.5 1.1 1 0 0 1 1 1 0 Conserved region in Nab1 Kin17_mid PF10357.9 ETN97453.1 - 0.04 13.8 2.8 0.081 12.8 2.8 1.5 1 1 0 1 1 1 0 Domain of Kin17 curved DNA-binding protein STAT_int PF02865.17 ETN97453.1 - 0.5 10.8 4.3 4.1 7.9 0.8 2.1 1 1 1 2 2 2 0 STAT protein, protein interaction domain GRAB PF10375.9 ETN97453.1 - 0.84 9.6 3.6 8.9 6.4 1.3 2.5 2 0 0 2 2 2 0 GRIP-related Arf-binding domain DUF5534 PF17686.1 ETN97454.1 - 0.092 13.0 0.3 0.21 11.9 0.0 1.7 2 1 0 2 2 2 0 Family of unknown function (DUF5534) Cnd1 PF12717.7 ETN97455.1 - 3.8e-06 27.0 2.8 3.3e-05 24.0 0.3 2.3 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 TAN PF11640.8 ETN97455.1 - 0.015 15.4 2.9 0.18 11.9 0.3 3.4 1 1 2 3 3 3 0 Telomere-length maintenance and DNA damage repair Arm-DNA-bind_2 PF12167.8 ETN97455.1 - 0.034 14.1 0.6 3.4 7.6 0.1 3.3 2 1 1 3 3 3 0 Arm DNA-binding domain N_Asn_amidohyd PF14736.6 ETN97455.1 - 0.069 12.3 0.6 0.85 8.7 0.2 2.1 1 1 1 2 2 2 0 Protein N-terminal asparagine amidohydrolase HEAT PF02985.22 ETN97455.1 - 0.07 13.4 0.4 53 4.5 0.0 4.2 5 0 0 5 5 5 0 HEAT repeat SPOB_ab PF14682.6 ETN97455.1 - 0.15 12.2 1.5 10 6.3 0.1 3.2 2 1 2 4 4 4 0 Sporulation initiation phospho-transferase B, C-terminal EF-hand_8 PF13833.6 ETN97455.1 - 0.15 11.9 0.5 19 5.2 0.0 3.4 3 0 0 3 3 3 0 EF-hand domain pair DUF5105 PF17118.5 ETN97455.1 - 0.57 9.9 4.6 8 6.2 0.1 3.9 2 1 3 5 5 5 0 Domain of unknown function (DUF5105) MSP7_C PF12948.7 ETN97455.1 - 0.59 10.8 12.2 4.3 8.0 0.3 3.9 2 2 3 5 5 5 0 MSP7-like protein C-terminal domain Zn_Tnp_IS1595 PF12760.7 ETN97456.1 - 1.1e-11 44.5 4.5 1.9e-11 43.8 4.5 1.4 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DDE_Tnp_IS1595 PF12762.7 ETN97456.1 - 1.7e-10 41.1 0.2 2.6e-10 40.5 0.2 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Peptidase_C26 PF07722.13 ETN97457.1 - 9e-38 130.2 0.0 1e-37 130.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 ETN97457.1 - 1.2e-07 31.7 0.0 3.2e-07 30.3 0.0 1.8 2 1 0 2 2 2 1 Glutamine amidotransferase class-I GATase_3 PF07685.14 ETN97457.1 - 0.023 14.3 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain PEPCK_ATP PF01293.20 ETN97458.1 - 5.3e-171 569.4 0.0 6.7e-171 569.0 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase DUF736 PF05284.12 ETN97458.1 - 0.023 14.6 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF736) AAA_16 PF13191.6 ETN97458.1 - 0.024 15.0 0.0 0.034 14.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain RRM_1 PF00076.22 ETN97459.1 - 1.7e-17 63.0 0.1 5.9e-17 61.3 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETN97459.1 - 0.00037 20.5 0.0 0.0012 18.9 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif GTP-bdg_M PF16360.5 ETN97459.1 - 1.1 9.9 5.9 18 6.0 0.4 2.8 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Hen1_Lam_C PF18441.1 ETN97461.1 - 1.8 8.4 5.3 18 5.2 0.1 2.3 2 1 0 2 2 2 0 Hen1 La-motif C-terminal domain Peptidase_S49_N PF08496.10 ETN97461.1 - 3 7.9 6.5 4.9 7.2 6.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Neur_chan_memb PF02932.16 ETN97461.1 - 8.2 6.4 8.7 10 6.1 8.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pep_M12B_propep PF01562.19 ETN97462.1 - 0.076 13.2 0.8 0.18 12.0 0.8 1.8 1 1 0 1 1 1 0 Reprolysin family propeptide DUF445 PF04286.12 ETN97464.1 - 0.12 12.2 6.3 0.15 11.8 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) cNMP_binding PF00027.29 ETN97465.1 - 3.8e-14 52.5 0.2 3.7e-12 46.1 0.2 2.3 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain DUF2076 PF09849.9 ETN97465.1 - 4.1 7.4 8.1 5.1 7.1 8.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) LRR_8 PF13855.6 ETN97466.1 - 1.7e-09 37.3 17.3 3.1e-07 30.0 3.6 3.4 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ETN97466.1 - 5.4e-07 29.8 21.9 0.00056 20.2 3.6 4.1 2 1 1 4 4 4 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETN97466.1 - 7e-05 22.8 13.1 0.19 12.4 0.2 4.8 4 0 0 4 4 4 3 Leucine Rich Repeat Peptidase_C14 PF00656.22 ETN97467.1 - 4.7e-05 23.5 0.1 5.8e-05 23.2 0.1 1.1 1 0 0 1 1 1 1 Caspase domain UPF0180 PF03698.13 ETN97468.1 - 0.00077 19.6 0.2 0.0011 19.1 0.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0180) DUF4443 PF14544.6 ETN97468.1 - 0.047 13.9 0.1 0.057 13.7 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4443) DUF3641 PF12345.8 ETN97468.1 - 0.094 12.7 0.7 0.11 12.5 0.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3641) PRE_C2HC PF07530.11 ETN97468.1 - 0.12 12.6 2.1 0.12 12.5 0.5 1.9 2 1 0 2 2 2 0 Associated with zinc fingers Arg_repressor PF01316.21 ETN97468.1 - 0.19 11.5 3.4 2 8.2 0.6 2.5 1 1 1 2 2 2 0 Arginine repressor, DNA binding domain SPATA1_C PF15743.5 ETN97469.1 - 0.022 14.9 2.0 0.023 14.8 0.2 1.7 2 0 0 2 2 2 0 Spermatogenesis-associated C-terminus TK PF00265.18 ETN97471.1 - 0.027 14.3 0.2 0.06 13.2 0.0 1.7 2 0 0 2 2 2 0 Thymidine kinase MFA1_2 PF17317.2 ETN97471.1 - 1.1 9.1 5.6 17 5.3 0.0 2.5 2 0 0 2 2 2 0 Mating hormone A-factor 1&2 HYR PF02494.16 ETN97472.1 - 0.038 14.3 0.2 0.081 13.3 0.2 1.6 1 0 0 1 1 1 0 HYR domain PT PF04886.12 ETN97472.1 - 0.88 9.2 23.4 1.6 8.3 6.7 2.4 2 0 0 2 2 2 0 PT repeat DUF3107 PF11305.8 ETN97473.1 - 0.13 12.6 0.0 0.3 11.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3107) DUF3781 PF12636.7 ETN97474.1 - 1.1 9.1 6.0 0.68 9.9 1.0 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF3781) WD40 PF00400.32 ETN97475.1 - 3.9e-09 37.0 0.3 9.5e-07 29.4 0.0 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETN97475.1 - 0.0025 17.2 0.1 0.0031 16.9 0.1 1.2 1 0 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETN97475.1 - 0.0034 17.6 0.1 0.071 13.4 0.0 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain GTP1_OBG PF01018.22 ETN97475.1 - 0.075 12.6 0.1 0.09 12.4 0.1 1.1 1 0 0 1 1 1 0 GTP1/OBG Adeno_GP19K PF04881.13 ETN97477.1 - 0.07 13.1 0.3 0.17 11.9 0.3 1.5 1 1 1 2 2 2 0 Adenovirus GP19K DMSP_lyase PF16867.5 ETN97477.1 - 0.09 12.4 0.0 0.097 12.3 0.0 1.1 1 0 0 1 1 1 0 Dimethlysulfonioproprionate lyase DUF2207 PF09972.9 ETN97477.1 - 0.18 10.5 1.7 0.19 10.5 1.7 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) NDUF_B4 PF07225.12 ETN97478.1 - 0.21 11.5 3.3 0.18 11.7 2.7 1.3 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) PepSY_TM_like_2 PF16357.5 ETN97478.1 - 0.65 9.9 2.8 0.71 9.8 2.8 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like Exo_endo_phos PF03372.23 ETN97479.1 - 0.00085 18.9 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VPS13 PF16908.5 ETN97481.1 - 0.047 13.5 0.0 0.052 13.3 0.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal LacI PF00356.21 ETN97481.1 - 0.055 13.3 0.2 0.16 11.8 0.2 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Kelch_6 PF13964.6 ETN97482.1 - 0.1 12.9 0.0 6 7.3 0.0 2.5 2 0 0 2 2 2 0 Kelch motif Oxidored_q3 PF00499.20 ETN97483.1 - 0.065 13.0 0.1 0.073 12.8 0.1 1.1 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 RNase_H PF00075.24 ETN97484.1 - 0.059 13.5 0.0 0.32 11.2 0.0 2.1 3 0 0 3 3 3 0 RNase H Ribosomal_S17 PF00366.20 ETN97485.1 - 0.19 11.9 4.1 0.2 11.8 0.3 2.2 1 1 1 2 2 2 0 Ribosomal protein S17 Sec66 PF09802.9 ETN97486.1 - 0.00046 19.8 1.5 0.00086 18.9 1.0 1.7 1 1 0 1 1 1 1 Preprotein translocase subunit Sec66 RGCC PF15151.6 ETN97486.1 - 0.02 15.1 0.4 0.074 13.3 0.1 2.0 2 0 0 2 2 2 0 Response gene to complement 32 protein family Anticodon_1 PF08264.13 ETN97486.1 - 0.027 14.4 0.6 0.16 11.9 0.1 2.4 2 0 0 2 2 2 0 Anticodon-binding domain of tRNA DMPK_coil PF08826.10 ETN97486.1 - 4.8 7.4 7.7 1.5 9.0 0.1 3.1 2 1 1 3 3 3 0 DMPK coiled coil domain like RGCC PF15151.6 ETN97487.1 - 0.051 13.8 0.4 0.11 12.7 0.1 1.7 2 0 0 2 2 2 0 Response gene to complement 32 protein family DMPK_coil PF08826.10 ETN97487.1 - 0.19 11.9 6.1 2.2 8.5 0.7 2.8 2 0 0 2 2 2 0 DMPK coiled coil domain like Metallophos PF00149.28 ETN97488.1 - 6.3e-07 30.1 0.2 1e-06 29.4 0.0 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Ank_3 PF13606.6 ETN97489.1 - 0.028 14.9 0.3 0.67 10.7 0.1 3.1 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 ETN97489.1 - 0.15 12.4 0.3 0.55 10.6 0.0 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) ClpB_D2-small PF10431.9 ETN97490.1 - 0.057 13.5 0.1 2.7 8.1 0.0 2.2 2 0 0 2 2 2 0 C-terminal, D2-small domain, of ClpB protein Csm1 PF12539.8 ETN97491.1 - 0.031 14.9 0.0 0.072 13.7 0.0 1.6 1 0 0 1 1 1 0 Chromosome segregation protein Csm1/Pcs1 DUF2981 PF11200.8 ETN97494.1 - 0.066 12.9 0.1 0.073 12.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) PerC PF06069.11 ETN97494.1 - 0.13 12.5 0.1 0.38 11.0 0.0 1.7 2 0 0 2 2 2 0 PerC transcriptional activator DUF5077 PF16871.5 ETN97495.1 - 0.13 12.2 2.6 0.16 11.9 2.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5077) DndB PF14072.6 ETN97497.1 - 0.0098 15.1 0.4 0.012 14.9 0.4 1.1 1 0 0 1 1 1 1 DNA-sulfur modification-associated Peptidase_M24_C PF16188.5 ETN97497.1 - 0.18 11.9 1.4 0.83 9.8 0.2 2.3 2 0 0 2 2 2 0 C-terminal region of peptidase_M24 DUF2415 PF10313.9 ETN97499.1 - 0.0028 17.6 0.0 0.0054 16.6 0.0 1.4 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) UPF0180 PF03698.13 ETN97499.1 - 0.092 12.9 1.5 1.3 9.2 0.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) Receptor_2B4 PF11465.8 ETN97500.1 - 0.093 12.9 0.4 0.24 11.6 0.1 1.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 Kelch_4 PF13418.6 ETN97501.1 - 0.005 16.8 0.1 0.0092 16.0 0.1 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN97501.1 - 0.012 15.8 0.0 0.023 15.0 0.0 1.4 1 0 0 1 1 1 0 Kelch motif FSA_C PF10479.9 ETN97501.1 - 0.013 13.6 7.1 0.015 13.5 7.1 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Kelch_1 PF01344.25 ETN97501.1 - 0.04 13.5 0.1 0.078 12.6 0.1 1.4 1 0 0 1 1 1 0 Kelch motif Mucin PF01456.17 ETN97501.1 - 0.053 13.5 16.4 0.081 12.9 16.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein TipE PF16972.5 ETN97501.1 - 2.5 7.2 9.3 2.9 7.0 9.3 1.0 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE BTB PF00651.31 ETN97502.1 - 1.2e-14 54.5 0.1 2e-14 53.7 0.1 1.3 1 1 0 1 1 1 1 BTB/POZ domain DUF2451 PF10474.9 ETN97503.1 - 0.011 15.5 1.3 0.013 15.3 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2451) DUF2469 PF10611.9 ETN97503.1 - 0.034 14.7 0.9 0.049 14.2 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2469) DUF3858 PF12970.7 ETN97503.1 - 0.036 14.1 0.8 0.087 12.9 0.2 1.8 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3858) CAP_GLY PF01302.25 ETN97507.1 - 0.089 12.8 0.0 3.1 7.9 0.0 2.3 2 0 0 2 2 2 0 CAP-Gly domain HRM PF02793.22 ETN97508.1 - 0.097 13.0 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Hormone receptor domain Peptidase_C14 PF00656.22 ETN97509.1 - 4.8e-06 26.7 0.1 6.6e-06 26.3 0.1 1.1 1 0 0 1 1 1 1 Caspase domain DUF3164 PF11363.8 ETN97509.1 - 0.091 12.4 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) WD40 PF00400.32 ETN97510.1 - 9.1e-07 29.5 1.2 2.5e-06 28.1 1.2 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat Tubulin_C PF03953.17 ETN97511.1 - 6.5e-14 52.2 0.0 1e-13 51.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain FAM221 PF14753.6 ETN97512.1 - 0.0058 16.2 4.1 0.0092 15.6 4.1 1.3 1 0 0 1 1 1 1 Protein FAM221A/B DUF1850 PF08905.11 ETN97513.1 - 0.0024 18.2 0.6 0.0048 17.2 0.6 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF1850) CAP_GLY PF01302.25 ETN97515.1 - 8.2e-33 112.2 2.7 1.3e-17 63.6 0.1 2.3 2 0 0 2 2 2 2 CAP-Gly domain BACK PF07707.15 ETN97515.1 - 2.3e-07 30.9 0.3 5.2e-05 23.3 0.3 2.6 2 0 0 2 2 2 2 BTB And C-terminal Kelch Myotub-related PF06602.14 ETN97517.1 - 5.7e-29 101.1 9.3 1.5e-20 73.4 0.1 3.1 1 1 2 3 3 3 3 Myotubularin-like phosphatase domain Y_phosphatase3 PF13350.6 ETN97517.1 - 0.069 13.1 0.1 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 Tyrosine phosphatase family CKAP2_C PF15297.6 ETN97517.1 - 0.13 11.3 4.9 0.19 10.7 4.9 1.2 1 0 0 1 1 1 0 Cytoskeleton-associated protein 2 C-terminus DTHCT PF08070.11 ETN97518.1 - 0.91 10.3 26.7 1.5 9.6 10.9 3.1 1 1 2 3 3 3 0 DTHCT (NUC029) region SOBP PF15279.6 ETN97518.1 - 1.5 9.3 7.9 1.9 9.0 7.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein ALMT PF11744.8 ETN97518.1 - 4 6.2 8.8 4.6 6.0 8.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter VGPC1_C PF16799.5 ETN97519.1 - 0.032 14.2 0.0 0.077 13.0 0.0 1.6 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 SDA1 PF05285.12 ETN97521.1 - 0.0055 16.2 9.6 0.0061 16.0 9.6 1.1 1 0 0 1 1 1 1 SDA1 DUF5308 PF17233.2 ETN97521.1 - 0.022 15.0 0.1 0.027 14.7 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Connexin PF00029.19 ETN97521.1 - 0.023 14.4 0.2 0.03 14.1 0.2 1.2 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 ETN97521.1 - 0.025 12.9 8.7 0.027 12.8 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein MRNIP PF15749.5 ETN97521.1 - 0.054 14.2 3.7 0.069 13.9 3.7 1.2 1 0 0 1 1 1 0 MRN-interacting protein CPSF100_C PF13299.6 ETN97521.1 - 0.059 13.6 4.0 0.079 13.1 4.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 ETN97521.1 - 0.12 11.1 1.2 0.1 11.3 1.2 1.1 1 0 0 1 1 1 0 Presenilin Radial_spoke PF04712.12 ETN97521.1 - 0.17 10.8 9.2 0.28 10.1 9.2 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein CobT PF06213.12 ETN97521.1 - 0.18 11.2 12.2 0.21 10.9 12.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 ETN97521.1 - 0.27 11.6 5.2 0.46 10.9 5.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 ETN97521.1 - 1.3 8.2 8.2 1.6 7.9 8.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Feld-I_B PF09252.10 ETN97522.1 - 0.0034 17.3 0.1 0.0071 16.3 0.1 1.5 1 0 0 1 1 1 1 Allergen Fel d I-B chain Glyco_transf_92 PF01697.27 ETN97523.1 - 0.003 17.3 4.0 0.0037 16.9 4.0 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 92 Nucleoside_tran PF01733.18 ETN97523.1 - 0.022 14.1 2.6 0.028 13.8 2.6 1.3 1 0 0 1 1 1 0 Nucleoside transporter AAA_11 PF13086.6 ETN97523.1 - 0.1 12.4 5.2 0.12 12.1 5.2 1.1 1 0 0 1 1 1 0 AAA domain PTPlike_phytase PF14566.6 ETN97523.1 - 0.12 12.5 1.8 0.16 12.1 1.8 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate DUF262 PF03235.14 ETN97523.1 - 0.16 12.1 8.3 0.18 11.9 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 HORMA PF02301.18 ETN97523.1 - 0.27 10.8 8.2 0.37 10.3 8.2 1.1 1 0 0 1 1 1 0 HORMA domain DUF4337 PF14235.6 ETN97523.1 - 0.79 9.8 5.9 1.2 9.3 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF641 PF04859.12 ETN97524.1 - 0.068 13.5 3.0 0.14 12.5 2.9 1.8 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Atg14 PF10186.9 ETN97524.1 - 0.17 11.0 6.2 0.21 10.6 6.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Syntaphilin PF15290.6 ETN97524.1 - 0.33 10.6 8.1 0.39 10.3 8.1 1.2 1 0 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp FAM76 PF16046.5 ETN97524.1 - 0.4 10.0 7.5 0.5 9.7 7.5 1.3 1 1 0 1 1 1 0 FAM76 protein BST2 PF16716.5 ETN97524.1 - 2.3 8.9 7.1 5 7.8 6.8 1.8 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 Tup_N PF08581.10 ETN97524.1 - 2.7 8.3 15.4 5.1 7.5 10.2 2.3 2 1 0 2 2 2 0 Tup N-terminal CC2-LZ PF16516.5 ETN97524.1 - 3.5 8.1 11.3 1.9 8.9 8.4 2.1 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF724 PF05266.14 ETN97524.1 - 3.7 7.3 9.9 4.2 7.1 9.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Sua5_yciO_yrdC PF01300.18 ETN97525.1 - 0.17 11.4 2.7 0.19 11.2 2.7 1.1 1 0 0 1 1 1 0 Telomere recombination Peptidase_S49_N PF08496.10 ETN97525.1 - 3.5 7.7 8.0 4.2 7.4 8.0 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF5398 PF17376.2 ETN97527.1 - 0.0049 17.5 1.9 0.0049 17.5 1.9 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5398) SR-25 PF10500.9 ETN97527.1 - 4.7 6.8 10.1 0.48 10.0 4.3 1.9 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein ABA_GPCR PF12430.8 ETN97528.1 - 0.041 13.7 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Abscisic acid G-protein coupled receptor Pkinase PF00069.25 ETN97529.1 - 3.7e-19 69.1 2.9 4.6e-19 68.8 2.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN97529.1 - 4.7e-11 42.5 1.2 5.8e-11 42.2 1.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Med6 PF04934.14 ETN97529.1 - 0.08 12.7 0.5 0.15 11.8 0.1 1.6 2 0 0 2 2 2 0 MED6 mediator sub complex component SMI1_KNR4 PF09346.10 ETN97529.1 - 0.11 12.8 0.0 0.14 12.6 0.0 1.3 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) ETM PF17577.2 ETN97529.1 - 0.79 10.3 5.6 4.1 8.0 1.5 2.6 1 1 1 2 2 2 0 ECORI-T site Lebercilin PF15619.6 ETN97531.1 - 0.00059 19.6 11.2 0.00059 19.6 11.2 2.1 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF3584 PF12128.8 ETN97531.1 - 0.005 14.4 15.1 0.0062 14.1 15.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF641 PF04859.12 ETN97531.1 - 0.0089 16.4 14.7 0.052 13.9 5.7 2.3 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) Pyr_excise PF03013.14 ETN97531.1 - 0.012 15.6 7.4 0.02 14.9 7.1 1.5 1 1 0 1 1 1 0 Pyrimidine dimer DNA glycosylase Csm1_N PF18504.1 ETN97531.1 - 0.019 15.3 19.4 0.024 15.0 3.1 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain YgbB PF02542.16 ETN97531.1 - 0.28 11.5 1.7 0.42 10.9 1.7 1.3 1 0 0 1 1 1 0 YgbB family YabA PF06156.13 ETN97531.1 - 0.54 10.9 23.6 1.9 9.2 12.9 2.2 1 1 1 2 2 2 0 Initiation control protein YabA DUF4140 PF13600.6 ETN97531.1 - 2 8.9 8.3 16 6.0 8.3 2.2 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) PRKG1_interact PF15898.5 ETN97531.1 - 2.1 9.3 21.0 0.42 11.5 11.9 2.2 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YfhO PF09586.10 ETN97531.1 - 2.1 6.5 10.5 16 3.5 10.5 1.9 1 1 0 1 1 1 0 Bacterial membrane protein YfhO DUF4200 PF13863.6 ETN97531.1 - 2.4 8.6 30.5 2.5 8.5 5.6 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DUF3251 PF11622.8 ETN97531.1 - 4.3 7.0 8.8 1.4 8.5 4.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3251) DUF2730 PF10805.8 ETN97531.1 - 6.1 7.0 12.2 3.3 7.9 6.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Kelch_4 PF13418.6 ETN97532.1 - 6.1e-07 29.3 0.1 0.00012 22.0 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN97532.1 - 1.3e-06 28.1 0.2 3.4e-05 23.6 0.3 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETN97532.1 - 4.3e-05 23.0 0.5 0.0001 21.8 0.2 1.7 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETN97532.1 - 7.3e-05 22.7 1.4 0.00057 19.8 0.8 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN97532.1 - 0.00043 20.5 0.0 0.073 13.4 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETN97532.1 - 0.00051 20.3 0.0 0.0055 17.0 0.0 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain HEAT_2 PF13646.6 ETN97534.1 - 1.7e-05 25.2 0.0 0.48 10.9 0.0 4.1 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 ETN97534.1 - 0.00023 21.6 0.0 1.1 9.8 0.0 4.5 5 0 0 5 5 5 1 HEAT-like repeat HEAT PF02985.22 ETN97534.1 - 0.0014 18.7 0.3 0.76 10.2 0.0 5.0 6 0 0 6 6 6 1 HEAT repeat CLASP_N PF12348.8 ETN97534.1 - 0.02 14.4 0.9 0.02 14.4 0.9 4.2 3 2 1 4 4 4 0 CLASP N terminal DUF2555 PF10742.9 ETN97534.1 - 0.18 11.6 0.5 53 3.7 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2555) Utp13 PF08625.11 ETN97534.1 - 0.31 11.0 3.3 2.7 7.9 1.6 3.1 2 1 0 2 2 2 0 Utp13 specific WD40 associated domain ThiI PF02568.14 ETN97534.1 - 0.98 9.0 4.2 0.54 9.8 0.1 2.5 3 0 0 3 3 3 0 Thiamine biosynthesis protein (ThiI) COX2_TM PF02790.15 ETN97535.1 - 1.8 8.8 4.0 13 6.0 0.0 3.4 4 0 0 4 4 4 0 Cytochrome C oxidase subunit II, transmembrane domain DUF2757 PF10955.8 ETN97536.1 - 0.0084 16.3 2.5 0.012 15.8 2.5 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2757) Peptidase_S49_N PF08496.10 ETN97537.1 - 0.14 12.2 6.6 0.15 12.1 6.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_C1 PF00112.23 ETN97540.1 - 4.8e-59 200.1 5.4 8.3e-59 199.3 5.4 1.4 1 0 0 1 1 1 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ETN97540.1 - 3e-13 50.0 0.7 6e-13 49.0 0.7 1.5 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) PhaP_Bmeg PF09602.10 ETN97540.1 - 0.026 14.5 0.1 0.046 13.7 0.1 1.3 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) WD40 PF00400.32 ETN97542.1 - 1.4e-13 51.1 6.4 3.9e-06 27.5 0.2 3.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN97542.1 - 0.002 16.8 0.4 1 8.0 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ricin_B_lectin PF00652.22 ETN97542.1 - 0.053 13.8 0.1 0.067 13.5 0.1 1.2 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain ANAPC4_WD40 PF12894.7 ETN97542.1 - 0.054 13.8 0.2 1.8 8.9 0.0 2.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETN97542.1 - 0.25 11.4 2.9 13 5.9 0.1 3.2 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Nop14 PF04147.12 ETN97544.1 - 2.1 6.5 16.0 2.1 6.4 16.0 1.1 1 0 0 1 1 1 0 Nop14-like family Pes-10 PF07149.11 ETN97544.1 - 4.9 6.1 16.8 5.3 6.0 16.8 1.0 1 0 0 1 1 1 0 Pes-10 DUF2457 PF10446.9 ETN97544.1 - 8.3 5.4 18.2 8.6 5.4 18.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) AIG1 PF04548.16 ETN97545.1 - 1.4e-08 34.4 0.0 2.1e-08 33.8 0.0 1.2 1 0 0 1 1 1 1 AIG1 family TelA PF05816.11 ETN97545.1 - 0.0046 16.1 0.1 0.0082 15.3 0.0 1.4 1 1 0 1 1 1 1 Toxic anion resistance protein (TelA) SeqA_N PF17206.3 ETN97545.1 - 0.056 12.8 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 SeqA protein N-terminal domain FliT PF05400.13 ETN97545.1 - 0.12 13.2 0.6 0.84 10.5 0.2 2.2 2 1 0 2 2 2 0 Flagellar protein FliT FTA4 PF13093.6 ETN97545.1 - 0.17 11.8 0.9 0.27 11.1 0.9 1.6 1 1 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 AIG1 PF04548.16 ETN97546.1 - 6.8e-12 45.2 0.0 1.3e-11 44.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 ETN97546.1 - 0.00044 20.3 0.0 0.00078 19.5 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase SeqA_N PF17206.3 ETN97546.1 - 0.083 12.2 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 SeqA protein N-terminal domain Pkinase PF00069.25 ETN97548.1 - 4.6e-19 68.8 0.0 8.4e-11 41.7 0.0 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETN97548.1 - 0.033 13.5 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase TPR_12 PF13424.6 ETN97549.1 - 1.6e-09 37.9 0.1 1.3e-08 35.0 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97549.1 - 2.8e-09 36.4 3.2 2.5e-06 27.2 0.6 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97549.1 - 6.1e-09 35.5 0.1 1.7e-06 27.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97549.1 - 8.7e-08 31.7 0.8 1.4e-05 24.8 0.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97549.1 - 4.4e-07 29.5 0.7 2.8e-06 26.9 0.8 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97549.1 - 3.4e-05 23.5 0.4 0.00018 21.3 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97549.1 - 0.0021 17.7 1.6 1.1 9.1 0.1 2.8 3 0 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 ETN97549.1 - 0.016 15.8 0.3 0.085 13.5 0.1 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETN97550.1 - 2.1e-47 158.1 6.5 3.8e-10 40.2 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97550.1 - 7.5e-20 71.0 1.0 3.3e-05 24.1 0.1 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETN97550.1 - 6.8e-10 39.2 1.0 1.6e-06 28.1 0.2 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETN97550.1 - 9.3e-10 38.0 0.1 0.13 11.2 0.0 4.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETN97550.1 - 5e-09 35.4 2.1 0.11 11.2 0.1 4.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN97550.1 - 7.4e-08 32.1 0.3 0.0032 16.8 0.0 2.9 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETN97550.1 - 7e-06 25.8 3.0 3.6 7.6 0.1 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETN97550.1 - 0.00034 19.5 2.3 0.43 9.3 0.7 3.1 1 1 1 2 2 2 1 Nup133 N terminal like DUF5570 PF17731.1 ETN97550.1 - 0.0012 19.0 0.2 5.7 7.0 0.0 3.3 1 1 1 4 4 4 2 Family of unknown function (DUF5570) SBD PF17882.1 ETN97550.1 - 0.006 16.4 0.2 9.6 6.1 0.0 3.5 1 1 3 4 4 4 1 OAA-family lectin sugar binding domain DUF5474 PF17568.2 ETN97550.1 - 0.02 14.9 0.1 4.2 7.5 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5474) Cytochrom_D1 PF02239.16 ETN97550.1 - 0.027 13.0 0.0 0.58 8.6 0.0 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain nos_propeller PF18764.1 ETN97550.1 - 0.032 14.2 0.1 37 4.3 0.0 3.6 3 1 1 4 4 4 0 Nitrous oxide reductase propeller repeat PALB2_WD40 PF16756.5 ETN97550.1 - 0.081 11.8 3.8 5.1 5.9 0.2 3.2 1 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETN97550.1 - 0.11 12.3 4.5 23 4.8 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature TPR_17 PF13431.6 ETN97551.1 - 1e-05 25.6 0.2 4.7e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97551.1 - 1.8e-05 24.4 0.2 0.00035 20.2 0.1 2.6 1 1 1 2 2 2 1 TPR repeat TPR_1 PF00515.28 ETN97551.1 - 3.3e-05 23.5 1.5 0.00021 21.0 0.2 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97551.1 - 0.00016 21.6 0.7 0.0029 17.7 0.2 3.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97551.1 - 0.00044 20.2 3.6 0.00055 19.9 0.2 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97551.1 - 0.0032 17.9 0.0 0.0084 16.6 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETN97551.1 - 0.097 12.8 0.0 0.63 10.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97551.1 - 0.11 12.8 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97551.1 - 0.12 13.1 0.0 0.23 12.1 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97551.1 - 0.15 12.2 0.0 0.64 10.2 0.0 2.1 1 0 0 1 1 1 0 Tetratricopeptide repeat Antiterm PF03589.13 ETN97551.1 - 0.2 12.0 0.8 2.5 8.5 0.0 2.8 3 0 0 3 3 3 0 Antitermination protein Corona_NSP4_C PF16348.5 ETN97551.1 - 1.3 9.9 4.1 1.5 9.7 0.8 2.5 2 0 0 2 2 2 0 Coronavirus nonstructural protein 4 C-terminus PSII_Pbs27 PF13326.6 ETN97551.1 - 8.4 6.7 7.4 30 4.9 0.6 3.3 2 1 1 3 3 3 0 Photosystem II Pbs27 CAP_GLY PF01302.25 ETN97552.1 - 0.00085 19.3 0.2 0.025 14.6 0.1 2.4 2 1 0 2 2 2 1 CAP-Gly domain Aida_C2 PF14186.6 ETN97552.1 - 0.16 11.6 0.0 14 5.3 0.0 2.0 1 1 1 2 2 2 0 Cytoskeletal adhesion PIN_8 PF18476.1 ETN97553.1 - 0.1 12.5 4.8 0.11 12.3 4.8 1.0 1 0 0 1 1 1 0 PIN like domain APG6_N PF17675.1 ETN97553.1 - 0.14 12.7 7.3 0.19 12.3 7.3 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4407 PF14362.6 ETN97553.1 - 0.3 10.4 2.8 0.35 10.2 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 ETN97555.1 - 5.7e-12 46.0 4.4 4.8e-07 30.4 0.5 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97555.1 - 2.7e-06 27.6 0.0 0.059 13.7 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97555.1 - 4.2e-05 22.4 0.7 7.1e-05 21.6 0.6 1.5 1 1 0 1 1 1 1 Nucleoporin Nup120/160 FAD_binding_8 PF08022.12 ETN97555.1 - 0.076 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 FAD-binding domain Kelch_6 PF13964.6 ETN97556.1 - 0.034 14.5 1.2 0.073 13.4 0.0 2.2 2 1 0 2 2 2 0 Kelch motif MutS_I PF01624.20 ETN97557.1 - 7.8e-30 103.4 0.1 1.4e-29 102.6 0.1 1.4 1 0 0 1 1 1 1 MutS domain I DUF3274 PF11678.8 ETN97557.1 - 0.31 10.2 11.9 0.49 9.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3274) Nop14 PF04147.12 ETN97557.1 - 0.73 8.0 26.6 0.92 7.6 26.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETN97557.1 - 1.3 7.2 23.6 1.7 6.8 23.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Merozoite_SPAM PF07133.11 ETN97557.1 - 2.1 8.3 45.1 3.8 7.5 45.1 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC27 PF09507.10 ETN97557.1 - 2.2 7.6 29.6 3 7.1 29.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SLC12 PF03522.15 ETN97557.1 - 4.9 6.1 13.9 6.6 5.6 13.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ETN97557.1 - 6.7 5.4 14.2 8.9 5.0 14.2 1.2 1 0 0 1 1 1 0 Presenilin RSN1_TM PF13967.6 ETN97558.1 - 0.044 13.6 1.0 0.14 11.9 1.0 1.8 1 1 0 1 1 1 0 Late exocytosis, associated with Golgi transport UPF0239 PF06783.11 ETN97558.1 - 0.3 11.3 0.0 0.3 11.3 0.0 2.7 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0239) ETRAMP PF09716.10 ETN97558.1 - 0.7 10.0 4.7 0.51 10.4 0.3 2.4 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) RAP80_UIM PF18282.1 ETN97558.1 - 1 9.2 4.9 17 5.2 1.0 3.2 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif Urocanase_C PF17392.2 ETN97559.1 - 0.048 13.1 0.2 0.11 11.9 0.2 1.6 1 1 1 2 2 2 0 Urocanase C-terminal domain NETI PF14044.6 ETN97559.1 - 0.12 12.1 0.0 0.4 10.5 0.0 1.8 2 0 0 2 2 2 0 NETI protein Yippee-Mis18 PF03226.14 ETN97560.1 - 3.2e-10 40.1 3.8 3.2e-10 40.1 3.8 1.8 2 0 0 2 2 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Spc7 PF08317.11 ETN97560.1 - 0.00044 19.2 17.9 0.00054 18.9 17.9 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein ERM PF00769.19 ETN97560.1 - 0.00055 19.8 13.0 0.00078 19.3 13.0 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Lebercilin PF15619.6 ETN97560.1 - 0.0018 17.9 17.1 0.0029 17.3 17.1 1.3 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 ETN97560.1 - 0.0031 17.6 23.4 0.0049 16.9 6.8 3.2 1 1 1 2 2 2 1 bZIP transcription factor ATG16 PF08614.11 ETN97560.1 - 0.0043 17.3 17.9 0.0061 16.8 17.9 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) V_ATPase_I PF01496.19 ETN97560.1 - 0.0091 14.0 7.2 0.01 13.8 7.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Cluap1 PF10234.9 ETN97560.1 - 0.012 15.0 14.6 0.017 14.6 14.6 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 DUF1664 PF07889.12 ETN97560.1 - 0.018 15.1 7.8 0.018 15.1 7.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 ETN97560.1 - 0.02 15.0 18.1 0.11 12.6 6.8 2.3 1 1 1 2 2 2 0 RasGAP C-terminus Lar_restr_allev PF14354.6 ETN97560.1 - 0.023 15.0 3.5 3.9 7.9 0.1 2.6 1 1 0 2 2 2 0 Restriction alleviation protein Lar DUF4806 PF16064.5 ETN97560.1 - 0.041 14.2 2.1 0.094 13.0 2.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) EzrA PF06160.12 ETN97560.1 - 0.049 11.8 12.4 0.068 11.3 12.4 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA AbfS_sensor PF18225.1 ETN97560.1 - 0.07 13.1 0.6 0.31 11.0 0.0 2.1 2 0 0 2 2 2 0 Sensor histidine kinase (AbfS) sensor domain DUF3584 PF12128.8 ETN97560.1 - 0.11 10.0 13.4 0.14 9.7 13.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GFA PF04828.14 ETN97560.1 - 0.11 12.8 7.0 0.13 12.7 0.5 2.9 1 1 2 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme SKA2 PF16740.5 ETN97560.1 - 0.12 12.2 17.7 0.83 9.5 17.4 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 TolA_bind_tri PF16331.5 ETN97560.1 - 0.14 12.3 15.9 0.046 13.8 7.8 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation BDV_P24 PF06595.11 ETN97560.1 - 0.17 11.7 1.7 0.28 11.0 1.5 1.4 1 1 0 1 1 1 0 Borna disease virus P24 protein CorA PF01544.18 ETN97560.1 - 0.2 11.0 5.1 0.34 10.2 5.1 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein GAS PF13851.6 ETN97560.1 - 0.22 10.9 24.7 0.024 14.0 18.6 1.9 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF773 PF05600.12 ETN97560.1 - 0.22 10.2 14.6 0.33 9.7 14.6 1.3 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 PEARLI-4 PF05278.12 ETN97560.1 - 0.23 11.0 15.7 0.12 11.9 13.6 1.5 1 1 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Mod_r PF07200.13 ETN97560.1 - 0.24 11.5 16.6 0.38 10.9 16.6 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Prominin PF05478.11 ETN97560.1 - 0.3 9.0 10.8 0.4 8.6 10.8 1.1 1 0 0 1 1 1 0 Prominin Nup54 PF13874.6 ETN97560.1 - 0.31 11.1 15.0 0.51 10.5 15.0 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Flagellin_N PF00669.20 ETN97560.1 - 0.33 11.1 6.7 0.36 10.9 4.6 2.0 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region Nup188_C PF18378.1 ETN97560.1 - 0.35 9.7 6.1 0.47 9.2 6.1 1.2 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain BMP2K_C PF15282.6 ETN97560.1 - 0.35 10.7 4.8 0.53 10.1 4.8 1.3 1 0 0 1 1 1 0 BMP-2-inducible protein kinase C-terminus CRR7 PF12095.8 ETN97560.1 - 0.47 10.9 7.1 0.65 10.5 4.7 2.4 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 APG6_N PF17675.1 ETN97560.1 - 0.5 10.9 27.1 1.2 9.7 17.9 2.3 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF3615 PF12274.8 ETN97560.1 - 0.56 10.8 5.5 0.32 11.5 2.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3615) Leu_zip PF15294.6 ETN97560.1 - 0.77 9.2 21.4 0.069 12.7 9.7 2.0 1 1 1 2 2 2 0 Leucine zipper DUF812 PF05667.11 ETN97560.1 - 0.78 8.5 21.4 1.4 7.7 21.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Jnk-SapK_ap_N PF09744.9 ETN97560.1 - 0.82 9.9 21.0 1.6 8.9 21.0 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 ZapB PF06005.12 ETN97560.1 - 0.91 10.0 26.8 2.3 8.7 3.9 2.6 1 1 2 3 3 3 0 Cell division protein ZapB PCRF PF03462.18 ETN97560.1 - 1.1 9.1 16.0 2 8.2 15.6 1.6 1 1 1 2 2 2 0 PCRF domain Fez1 PF06818.15 ETN97560.1 - 1.1 9.7 20.9 5.1 7.5 21.0 1.8 1 1 0 1 1 1 0 Fez1 DivIC PF04977.15 ETN97560.1 - 1.2 9.0 20.7 4.5 7.1 6.4 3.0 1 1 2 3 3 3 0 Septum formation initiator Med30 PF11315.8 ETN97560.1 - 1.4 9.1 14.1 2.3 8.4 14.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 30 Pga1 PF10333.9 ETN97560.1 - 1.4 8.8 4.5 0.71 9.7 0.4 2.0 1 1 1 2 2 2 0 GPI-Mannosyltransferase II co-activator DUF2680 PF10925.8 ETN97560.1 - 1.5 8.8 10.5 0.77 9.8 0.5 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF2680) DUF948 PF06103.11 ETN97560.1 - 1.6 9.0 5.2 4.9 7.5 5.0 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FapA PF03961.13 ETN97560.1 - 1.8 7.1 17.9 4.4 5.8 17.9 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 ETN97560.1 - 1.8 9.2 19.8 1.4e+02 3.1 19.8 2.6 1 1 0 1 1 1 0 Initiation control protein YabA DUF724 PF05266.14 ETN97560.1 - 1.8 8.3 15.0 3.4 7.4 15.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) 5_nucleotid PF05761.14 ETN97560.1 - 1.9 7.3 7.4 3.1 6.6 7.4 1.4 1 0 0 1 1 1 0 5' nucleotidase family GIT_CC PF16559.5 ETN97560.1 - 2 8.4 16.3 1.4 8.8 5.9 2.6 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMPIT PF07851.13 ETN97560.1 - 2.3 7.4 16.7 3.2 6.9 16.3 1.4 1 1 0 1 1 1 0 TMPIT-like protein HAUS6_N PF14661.6 ETN97560.1 - 2.4 7.7 15.1 3.4 7.2 15.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Occludin_ELL PF07303.13 ETN97560.1 - 2.8 8.7 14.8 0.7 10.6 7.4 2.2 1 1 1 2 2 2 0 Occludin homology domain Syntaxin_2 PF14523.6 ETN97560.1 - 3.3 8.1 13.8 15 6.0 2.9 2.4 2 1 1 3 3 2 0 Syntaxin-like protein DHHA1 PF02272.19 ETN97560.1 - 3.4 8.1 9.6 2.6 8.5 0.3 2.3 2 0 0 2 2 2 0 DHHA1 domain AHD PF17793.1 ETN97560.1 - 4.1 7.3 6.3 17 5.3 1.0 2.8 2 1 0 2 2 2 0 ANC1 homology domain (AHD) HlyD_2 PF12700.7 ETN97560.1 - 4.1 6.0 13.1 6.1 5.5 13.1 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Prefoldin_2 PF01920.20 ETN97560.1 - 4.4 7.3 24.3 1.2 9.1 7.2 3.2 1 1 2 3 3 3 0 Prefoldin subunit Seryl_tRNA_N PF02403.22 ETN97560.1 - 5.3 7.3 21.9 8.3 6.7 12.3 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4795 PF16043.5 ETN97560.1 - 5.7 6.5 22.9 3 7.4 12.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) bZIP_Maf PF03131.17 ETN97560.1 - 6 7.5 16.9 1.2 9.7 7.7 2.6 1 1 1 2 2 2 0 bZIP Maf transcription factor Tho2 PF11262.8 ETN97560.1 - 6.2 5.9 13.1 11 5.1 13.1 1.4 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DASH_Dam1 PF08653.10 ETN97560.1 - 6.8 6.6 8.5 18 5.2 0.8 3.2 1 1 1 3 3 3 0 DASH complex subunit Dam1 SlyX PF04102.12 ETN97560.1 - 7.2 7.3 15.9 12 6.6 3.0 3.1 1 1 2 3 3 3 0 SlyX SWI-SNF_Ssr4 PF08549.10 ETN97560.1 - 7.4 5.1 10.4 9.5 4.7 10.4 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF3450 PF11932.8 ETN97560.1 - 8.4 5.6 17.3 4.6 6.5 9.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HALZ PF02183.18 ETN97560.1 - 9.3 6.6 21.5 0.91 9.8 8.9 3.4 1 1 1 3 3 3 0 Homeobox associated leucine zipper UCH PF00443.29 ETN97561.1 - 1.1e-15 57.9 7.3 1.6e-15 57.4 7.3 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RapA_C PF12137.8 ETN97561.1 - 0.064 12.3 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal UCH_1 PF13423.6 ETN97561.1 - 0.63 9.6 14.5 0.48 10.0 10.8 2.6 2 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase GET2 PF08690.10 ETN97563.1 - 0.0026 17.5 0.7 0.0042 16.8 0.7 1.4 1 1 0 1 1 1 1 GET complex subunit GET2 LAP1C PF05609.12 ETN97563.1 - 0.018 14.1 2.2 0.025 13.7 2.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RRN3 PF05327.11 ETN97563.1 - 0.069 11.7 11.0 0.1 11.2 11.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.12 ETN97563.1 - 2.4 7.5 18.8 2.8 7.3 18.8 1.2 1 0 0 1 1 1 0 SDA1 C2 PF00168.30 ETN97565.1 - 0.0043 17.3 0.4 0.015 15.5 0.2 2.0 1 1 0 2 2 2 1 C2 domain CS PF04969.16 ETN97566.1 - 4.2e-06 27.7 0.1 8e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 CS domain PIH1_CS PF18201.1 ETN97566.1 - 0.05 14.0 0.0 0.099 13.1 0.0 1.5 1 0 0 1 1 1 0 PIH1 CS-like domain CS PF04969.16 ETN97567.1 - 1.6e-06 29.0 0.1 3.6e-06 27.9 0.1 1.5 1 0 0 1 1 1 1 CS domain PIH1_CS PF18201.1 ETN97567.1 - 0.027 14.9 0.0 0.088 13.2 0.0 1.8 1 1 1 2 2 2 0 PIH1 CS-like domain MG1 PF17790.1 ETN97567.1 - 0.23 11.9 3.4 1.8 9.1 0.0 2.7 2 1 0 2 2 2 0 Macroglobulin domain MG1 WD40 PF00400.32 ETN97569.1 - 4.4e-33 112.8 26.4 3.1e-06 27.8 1.3 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97569.1 - 1.1e-09 38.5 4.8 0.032 14.5 0.1 6.2 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97569.1 - 1.8e-06 26.9 9.0 0.41 9.2 0.1 5.5 1 1 4 6 6 6 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETN97569.1 - 0.00023 21.8 7.3 0.00023 21.8 7.3 2.6 3 0 0 3 3 3 1 TRAF-type zinc finger XRN_M PF17846.1 ETN97569.1 - 0.1 11.5 7.1 0.17 10.8 7.1 1.3 1 0 0 1 1 1 0 Xrn1 helical domain DUF641 PF04859.12 ETN97569.1 - 0.37 11.1 13.8 0.79 10.1 12.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Csm1_N PF18504.1 ETN97569.1 - 8.2 6.8 20.1 2.1 8.8 10.5 2.7 1 1 1 2 2 2 0 Csm1 N-terminal domain RGS PF00615.19 ETN97570.1 - 0.11 12.8 2.1 0.35 11.1 0.1 2.2 2 0 0 2 2 2 0 Regulator of G protein signaling domain CDC45 PF02724.14 ETN97574.1 - 8.2 4.6 35.7 4.3 5.5 15.7 2.1 2 0 0 2 2 2 0 CDC45-like protein AAA_7 PF12775.7 ETN97576.1 - 0.0021 17.6 0.2 0.0077 15.8 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETN97576.1 - 0.013 15.4 0.1 0.093 12.6 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 ETN97576.1 - 0.074 13.6 1.6 0.19 12.2 0.0 2.5 3 0 0 3 3 3 0 ABC transporter Roc PF08477.13 ETN97576.1 - 0.082 13.1 1.4 6.1 7.1 0.0 3.8 3 1 1 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ETN97576.1 - 0.083 13.2 1.4 1.1 9.5 0.0 3.4 4 0 0 4 4 4 0 AAA domain AAA_7 PF12775.7 ETN97577.1 - 0.0073 15.8 0.1 0.043 13.3 0.0 2.2 1 1 1 2 2 2 1 P-loop containing dynein motor region DUF5078 PF16877.5 ETN97577.1 - 0.055 13.9 0.9 1.3 9.5 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5078) DUF2570 PF10828.8 ETN97578.1 - 0.02 14.7 1.2 0.052 13.4 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) DUF2207 PF09972.9 ETN97579.1 - 0.002 17.0 0.4 0.002 17.0 0.4 2.1 1 1 1 2 2 2 1 Predicted membrane protein (DUF2207) DUF5009 PF16401.5 ETN97579.1 - 0.34 10.4 4.7 1.7 8.1 4.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF5009) DUF2569 PF10754.9 ETN97579.1 - 0.51 10.8 7.0 0.031 14.7 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Pkinase_Tyr PF07714.17 ETN97580.1 - 5e-53 180.0 0.1 2.7e-26 92.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETN97580.1 - 3.6e-45 154.4 0.1 2e-21 76.6 0.3 2.1 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.14 ETN97580.1 - 0.077 12.3 2.3 0.44 9.9 2.3 2.0 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DeoC PF01791.9 ETN97582.1 - 1.8e-09 37.6 1.1 0.0017 18.0 0.9 2.2 2 0 0 2 2 2 2 DeoC/LacD family aldolase MH1 PF03165.16 ETN97582.1 - 0.056 13.6 1.0 0.17 12.1 0.0 2.3 2 1 1 3 3 3 0 MH1 domain Peptidase_S3 PF00944.19 ETN97583.1 - 0.04 13.7 0.0 0.076 12.8 0.0 1.4 1 0 0 1 1 1 0 Alphavirus core protein PRP21_like_P PF12230.8 ETN97587.1 - 4e-17 62.8 0.6 4e-17 62.8 0.6 3.0 2 1 1 3 3 3 1 Pre-mRNA splicing factor PRP21 like protein GPS2_interact PF15784.5 ETN97587.1 - 0.027 14.9 5.0 0.11 13.0 5.0 2.1 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain DUF4349 PF14257.6 ETN97587.1 - 0.056 12.9 0.4 0.13 11.7 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) PIEZO PF15917.5 ETN97587.1 - 0.15 11.5 3.0 0.3 10.5 3.0 1.6 1 0 0 1 1 1 0 Piezo TraC PF07820.12 ETN97587.1 - 0.16 12.3 6.4 0.4 11.0 4.3 2.5 2 0 0 2 2 2 0 TraC-like protein MscS_porin PF12795.7 ETN97590.1 - 0.0053 16.3 2.4 0.0053 16.3 2.4 2.0 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain Filament PF00038.21 ETN97590.1 - 0.0084 15.7 5.7 0.14 11.7 0.8 2.0 2 0 0 2 2 2 2 Intermediate filament protein TPR_MLP1_2 PF07926.12 ETN97590.1 - 0.0092 16.1 18.0 0.13 12.3 7.2 2.0 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ETN97590.1 - 0.016 14.1 14.9 0.064 12.1 5.2 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein DegS PF05384.11 ETN97590.1 - 0.021 14.3 8.0 1.1 8.8 0.1 2.1 2 0 0 2 2 2 0 Sensor protein DegS HIP1_clath_bdg PF16515.5 ETN97590.1 - 0.028 15.0 13.5 0.14 12.8 4.0 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-F_leu_zip PF10473.9 ETN97590.1 - 0.035 14.1 17.5 0.29 11.1 6.9 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.13 ETN97590.1 - 0.039 13.7 5.6 0.59 9.8 1.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Prefoldin_2 PF01920.20 ETN97590.1 - 0.054 13.4 11.5 0.12 12.3 2.7 2.2 2 0 0 2 2 2 0 Prefoldin subunit DLP_helical PF18709.1 ETN97590.1 - 0.067 12.4 8.5 0.086 12.0 2.8 2.0 2 0 0 2 2 2 0 Dynamin-like helical domain PRKG1_interact PF15898.5 ETN97590.1 - 0.069 14.1 10.5 1.6 9.7 3.8 2.1 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF5339 PF17274.2 ETN97590.1 - 0.087 13.7 5.3 0.41 11.5 0.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5339) HAUS5 PF14817.6 ETN97590.1 - 0.16 10.7 7.7 0.14 10.9 1.5 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 5 FliJ PF02050.16 ETN97590.1 - 0.17 12.1 7.3 0.58 10.4 7.3 1.7 1 1 0 1 1 1 0 Flagellar FliJ protein Golgin_A5 PF09787.9 ETN97590.1 - 0.18 11.2 11.3 1.8 7.9 11.3 1.9 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF2524 PF10732.9 ETN97590.1 - 0.21 11.9 5.8 1.8 8.9 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) APG6_N PF17675.1 ETN97590.1 - 0.26 11.8 16.6 0.89 10.1 5.8 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region G-gamma PF00631.22 ETN97590.1 - 0.33 11.0 7.3 1.6 8.8 1.7 2.4 2 0 0 2 2 2 0 GGL domain GrpE PF01025.19 ETN97590.1 - 0.34 10.6 11.1 1.1 8.9 4.3 2.0 2 0 0 2 2 2 0 GrpE Jnk-SapK_ap_N PF09744.9 ETN97590.1 - 0.41 10.9 13.3 0.58 10.4 13.3 1.3 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Sec8_exocyst PF04048.14 ETN97590.1 - 0.65 9.9 6.5 1.2 9.0 0.7 2.1 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain KfrA_N PF11740.8 ETN97590.1 - 0.66 10.7 8.6 1.6 9.4 2.7 2.1 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term MIT_C PF16565.5 ETN97590.1 - 0.69 9.9 3.6 4.7 7.2 0.4 2.0 2 0 0 2 2 2 0 Phospholipase D-like domain at C-terminus of MIT Syntaxin-6_N PF09177.11 ETN97590.1 - 0.77 10.4 8.2 0.68 10.5 2.5 2.1 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF5082 PF16888.5 ETN97590.1 - 1 9.6 8.3 1.2 9.4 2.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) DUF4140 PF13600.6 ETN97590.1 - 1.4 9.4 7.8 4.2 7.9 2.3 2.1 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF3391 PF11871.8 ETN97590.1 - 1.9 9.1 5.8 8 7.0 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Seryl_tRNA_N PF02403.22 ETN97590.1 - 1.9 8.8 11.3 3.8 7.8 2.7 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain H-kinase_dim PF02895.14 ETN97590.1 - 2.2 8.7 6.3 3.8 8.0 2.3 2.2 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Spc24 PF08286.11 ETN97590.1 - 2.3 8.5 11.8 4.6 7.5 2.9 2.1 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4404 PF14357.6 ETN97590.1 - 2.4 8.9 8.5 12 6.6 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) THOC7 PF05615.13 ETN97590.1 - 2.5 8.4 13.9 1.3e+02 2.9 13.9 2.1 1 1 0 1 1 1 0 Tho complex subunit 7 FlaC_arch PF05377.11 ETN97590.1 - 3.3 8.2 11.3 17 5.9 3.0 3.0 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) UPF0449 PF15136.6 ETN97590.1 - 3.8 8.0 8.5 2.6 8.6 1.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 YabA PF06156.13 ETN97590.1 - 5.5 7.7 9.5 4.7 7.9 2.6 2.1 2 0 0 2 2 2 0 Initiation control protein YabA OmpH PF03938.14 ETN97590.1 - 6.4 7.1 11.1 6.4 7.1 3.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) SR-25 PF10500.9 ETN97593.1 - 7.8 6.0 23.1 9.2 5.8 23.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spt20 PF12090.8 ETN97594.1 - 0.00016 21.4 8.7 0.00018 21.2 8.7 1.1 1 0 0 1 1 1 1 Spt20 family DUF918 PF06033.11 ETN97594.1 - 0.018 15.0 3.8 0.92 9.5 0.2 2.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF918) ANAPC1 PF12859.7 ETN97594.1 - 0.097 13.2 1.4 0.11 13.0 1.4 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 Med24_N PF11277.8 ETN97594.1 - 0.17 9.9 8.0 0.21 9.6 8.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 24 N-terminal Membralin PF09746.9 ETN97594.1 - 1.6 7.7 6.4 1.8 7.5 6.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein Nop25 PF09805.9 ETN97595.1 - 1 9.8 18.4 1.1 9.7 18.4 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) PIEZO PF15917.5 ETN97596.1 - 3.4 7.1 11.2 3.8 6.9 11.2 1.0 1 0 0 1 1 1 0 Piezo WD40 PF00400.32 ETN97597.1 - 7.1e-18 64.6 2.6 9.4e-05 23.1 0.0 4.6 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN97597.1 - 3.5e-07 29.2 0.5 0.015 14.0 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN97597.1 - 1.9e-06 28.0 0.0 1.6 9.1 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97597.1 - 0.00026 20.4 0.8 0.18 11.1 0.5 2.3 1 1 1 2 2 2 2 WD40-like domain Peptidase_M1_N PF17900.1 ETN97602.1 - 8.8e-05 22.8 0.1 0.00035 20.8 0.0 1.8 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain RNA_bind PF08675.11 ETN97602.1 - 0.021 14.8 0.0 0.034 14.2 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain DUF3504 PF12012.8 ETN97603.1 - 0.039 13.8 3.3 0.069 13.1 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) DUF1115 PF06544.12 ETN97603.1 - 0.064 13.3 9.3 0.11 12.6 9.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) HDA2-3 PF11496.8 ETN97603.1 - 1.4 8.0 6.7 2.3 7.3 6.7 1.3 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 PBP_sp32 PF07222.12 ETN97603.1 - 2.8 7.3 7.6 4.1 6.8 7.6 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Connexin PF00029.19 ETN97603.1 - 2.8 7.6 7.2 4.5 7.0 7.2 1.3 1 0 0 1 1 1 0 Connexin WD40 PF00400.32 ETN97604.1 - 2.5e-15 56.6 6.5 1.1e-07 32.4 0.6 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat FAM76 PF16046.5 ETN97604.1 - 0.0002 20.9 15.1 0.00027 20.4 15.1 1.3 1 0 0 1 1 1 1 FAM76 protein Gp58 PF07902.11 ETN97604.1 - 0.00023 19.6 7.3 0.0003 19.2 7.3 1.1 1 0 0 1 1 1 1 gp58-like protein ANAPC4_WD40 PF12894.7 ETN97604.1 - 0.0038 17.5 0.1 0.021 15.1 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Atg14 PF10186.9 ETN97604.1 - 0.34 10.0 13.9 0.43 9.6 13.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lipoprotein_3 PF00938.17 ETN97604.1 - 0.65 10.2 8.5 0.1 12.8 1.7 2.6 1 1 0 2 2 2 0 Lipoprotein Ly49 PF08391.10 ETN97604.1 - 3.3 8.1 19.0 0.32 11.3 5.5 2.6 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region DUF1189 PF06691.11 ETN97604.1 - 6.2 6.3 17.9 9.4 5.7 17.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) DUF5383 PF17355.2 ETN97605.1 - 0.18 12.1 0.2 0.18 12.1 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5383) ZapB PF06005.12 ETN97607.1 - 0.0073 16.7 2.1 0.0073 16.7 2.1 8.0 2 2 4 6 6 5 3 Cell division protein ZapB PI3K_P85_iSH2 PF16454.5 ETN97607.1 - 0.0084 15.7 9.5 0.0084 15.7 9.5 5.9 2 1 2 4 4 4 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GAS PF13851.6 ETN97607.1 - 0.015 14.7 74.4 0.14 11.5 19.8 4.8 2 2 2 4 4 4 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ETN97607.1 - 0.032 14.2 68.3 0.11 12.6 8.4 5.1 2 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 ETN97607.1 - 0.14 12.7 73.1 4.2 7.9 16.5 6.1 1 1 5 6 6 6 0 Apg6 coiled-coil region bZIP_1 PF00170.21 ETN97607.1 - 0.2 11.8 53.8 0.98 9.6 1.5 8.4 5 2 3 9 9 9 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 ETN97607.1 - 0.22 11.6 77.0 0.049 13.7 8.4 6.2 2 2 4 6 6 6 0 TPR/MLP1/MLP2-like protein KASH_CCD PF14662.6 ETN97607.1 - 0.3 10.9 73.6 0.044 13.6 2.4 4.8 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 ETN97607.1 - 0.7 10.0 70.0 1.8 8.7 10.2 4.7 1 1 1 4 4 4 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ETN97607.1 - 5.1 7.3 72.8 2.3 8.4 11.1 4.9 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ETN97607.1 - 7.5 5.3 69.7 1.2 7.9 9.5 4.6 2 2 3 5 5 5 0 Spc7 kinetochore protein JIP_LZII PF16471.5 ETN97607.1 - 8.1 6.7 54.6 2.8 8.2 5.3 8.5 4 3 4 8 8 8 0 JNK-interacting protein leucine zipper II CALCOCO1 PF07888.11 ETN97607.1 - 9.2 5.0 60.5 0.3 9.9 20.8 3.2 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Phage_CII PF05269.11 ETN97610.1 - 0.11 12.7 0.1 1.6 9.0 0.0 2.7 3 0 0 3 3 3 0 Bacteriophage CII protein NOA36 PF06524.12 ETN97612.1 - 1.9 7.7 6.9 2.9 7.1 6.9 1.2 1 0 0 1 1 1 0 NOA36 protein TetR_C_23 PF17931.1 ETN97612.1 - 2.8 8.1 6.1 35 4.5 0.1 3.6 2 1 1 4 4 4 0 Tetracyclin repressor-like, C-terminal domain PPR PF01535.20 ETN97613.1 - 3.4e-13 48.9 1.6 0.00012 22.1 0.1 3.3 3 0 0 3 3 3 3 PPR repeat PPR_2 PF13041.6 ETN97613.1 - 4.6e-13 49.1 3.0 4.6e-07 29.9 0.1 3.0 2 1 1 3 3 3 3 PPR repeat family PPR_1 PF12854.7 ETN97613.1 - 7.6e-09 35.1 0.1 0.00067 19.3 0.0 3.1 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.6 ETN97613.1 - 1.1e-08 35.0 0.0 0.00027 20.9 0.0 3.0 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ETN97613.1 - 0.0094 15.3 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETN97613.1 - 0.017 15.0 0.2 0.042 13.7 0.1 1.8 2 1 1 3 3 3 0 Mitochondrial ATPase expression WD40 PF00400.32 ETN97614.1 - 4.9e-24 84.1 12.0 4.3e-07 30.5 0.2 6.2 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97614.1 - 7.3e-12 45.4 3.4 0.0069 16.7 0.0 5.1 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97614.1 - 4.4e-07 28.9 3.2 0.23 10.1 0.0 4.5 2 1 3 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETN97614.1 - 0.028 14.3 0.5 2.1 8.2 0.2 2.7 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF883 PF05957.13 ETN97614.1 - 0.36 11.5 5.4 0.21 12.2 2.8 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) FAM76 PF16046.5 ETN97614.1 - 0.59 9.4 18.4 1.1 8.5 18.4 1.4 1 0 0 1 1 1 0 FAM76 protein Cupin_8 PF13621.6 ETN97614.1 - 0.65 9.7 4.7 1.3 8.7 4.7 1.5 1 1 0 1 1 1 0 Cupin-like domain SH3_13 PF18335.1 ETN97614.1 - 2.6 7.9 0.0 2.6 7.9 0.0 3.9 4 1 1 5 5 5 0 ATP-dependent RecD-like DNA helicase SH3 domain TMPIT PF07851.13 ETN97614.1 - 6 6.0 10.9 9.4 5.4 10.9 1.4 1 0 0 1 1 1 0 TMPIT-like protein ATG16 PF08614.11 ETN97615.1 - 0.095 12.9 41.9 0.095 12.9 21.5 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) NACHT PF05729.12 ETN97618.1 - 0.12 12.2 0.0 0.12 12.2 0.0 1.1 1 0 0 1 1 1 0 NACHT domain WD40 PF00400.32 ETN97619.1 - 8.3e-12 45.4 3.5 7.6e-06 26.6 0.0 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97619.1 - 0.0034 17.7 0.3 0.24 11.7 0.1 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97619.1 - 0.037 12.7 0.0 1.5 7.4 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ComGF PF15980.5 ETN97619.1 - 0.084 13.2 0.0 0.11 12.9 0.0 1.2 1 0 0 1 1 1 0 Putative Competence protein ComGF CDC45 PF02724.14 ETN97620.1 - 0.032 12.5 8.4 0.035 12.4 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 ETN97620.1 - 0.036 13.9 11.8 0.044 13.6 11.8 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF913 PF06025.12 ETN97620.1 - 0.038 13.0 3.8 0.043 12.8 3.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4637 PF15470.6 ETN97620.1 - 0.052 13.3 6.0 0.077 12.7 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) BUD22 PF09073.10 ETN97620.1 - 0.081 12.2 9.3 0.096 12.0 9.3 1.2 1 0 0 1 1 1 0 BUD22 DUF4471 PF14740.6 ETN97620.1 - 0.09 12.0 8.2 0.11 11.7 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) PI3K_1B_p101 PF10486.9 ETN97620.1 - 0.13 10.0 10.4 0.15 9.8 10.4 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NOA36 PF06524.12 ETN97620.1 - 0.14 11.5 14.1 0.18 11.1 14.1 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETN97620.1 - 0.14 12.5 9.9 0.24 11.8 9.9 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4746 PF15928.5 ETN97620.1 - 0.18 11.2 13.1 0.22 10.9 13.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM176 PF14851.6 ETN97620.1 - 0.18 11.5 7.9 0.29 10.8 7.9 1.4 1 0 0 1 1 1 0 FAM176 family Myc_N PF01056.18 ETN97620.1 - 0.19 11.6 7.4 0.19 11.6 7.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Methyltransf_32 PF13679.6 ETN97620.1 - 0.23 11.4 4.7 0.67 9.9 4.7 1.7 1 1 0 1 1 1 0 Methyltransferase domain DUF4446 PF14584.6 ETN97620.1 - 0.23 11.4 9.6 0.047 13.7 2.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) RP-C_C PF11800.8 ETN97620.1 - 0.92 9.6 6.5 1.1 9.3 6.5 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 ETN97620.1 - 0.98 8.6 2.3 1.1 8.5 2.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2457 PF10446.9 ETN97620.1 - 1.4 8.0 13.6 1.6 7.8 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2428 PF10350.9 ETN97620.1 - 2.5 7.3 7.5 20 4.3 0.1 1.9 1 1 1 2 2 2 0 Putative death-receptor fusion protein (DUF2428) DUF740 PF05340.12 ETN97620.1 - 6.4 5.4 10.2 7.3 5.2 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) CobT PF06213.12 ETN97620.1 - 6.9 6.0 14.3 7.8 5.8 14.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TRAP_alpha PF03896.16 ETN97620.1 - 8.9 5.4 12.9 9.7 5.3 12.6 1.3 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF1192 PF06698.11 ETN97621.1 - 0.32 11.1 5.4 0.54 10.4 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1192) SUKH-3 PF14433.6 ETN97621.1 - 0.39 11.2 2.7 1.9 9.0 0.4 2.6 3 0 0 3 3 3 0 SUKH-3 immunity protein Sen15 PF09631.10 ETN97624.1 - 0.0087 16.3 0.0 0.011 16.1 0.0 1.1 1 0 0 1 1 1 1 Sen15 protein EVI2A PF05399.11 ETN97625.1 - 0.082 12.5 11.2 0.11 12.1 11.2 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Menin PF05053.13 ETN97625.1 - 0.24 9.7 4.8 0.27 9.6 4.8 1.1 1 0 0 1 1 1 0 Menin ATF7IP_BD PF16788.5 ETN97625.1 - 0.76 9.8 12.1 1.1 9.4 12.1 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain BSP_II PF05432.11 ETN97625.1 - 3.1 7.4 15.8 4.1 7.0 15.8 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Snf7 PF03357.21 ETN97626.1 - 0.0078 15.8 2.8 0.0078 15.8 2.8 1.8 2 0 0 2 2 2 1 Snf7 XH PF03469.14 ETN97626.1 - 0.016 15.1 2.8 0.64 9.9 0.0 2.2 2 0 0 2 2 2 0 XH domain OrfB_IS605 PF01385.19 ETN97626.1 - 0.18 12.1 5.6 5 7.4 0.1 2.3 1 1 0 2 2 2 0 Probable transposase DUF501 PF04417.12 ETN97626.1 - 0.26 11.1 3.3 1.3 8.9 0.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF501) zf-RING_11 PF17123.5 ETN97628.1 - 0.0039 16.9 1.4 0.0039 16.9 1.4 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETN97628.1 - 0.0057 16.5 1.1 0.011 15.6 1.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Inhibitor_I71 PF12628.7 ETN97628.1 - 0.0058 16.5 0.7 0.0092 15.8 0.7 1.3 1 0 0 1 1 1 1 Falstatin, cysteine peptidase inhibitor zf-C3HC4_3 PF13920.6 ETN97628.1 - 0.0066 16.3 0.5 0.01 15.7 0.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETN97628.1 - 0.014 15.7 0.6 0.027 14.8 0.6 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 ETN97628.1 - 0.026 14.5 1.5 0.054 13.5 1.5 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 ETN97628.1 - 0.069 13.1 0.4 0.13 12.3 0.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Vps39_2 PF10367.9 ETN97628.1 - 0.11 12.9 0.2 0.23 11.9 0.2 1.5 1 0 0 1 1 1 0 Vacuolar sorting protein 39 domain 2 RPN2_C PF18004.1 ETN97628.1 - 0.15 11.9 5.6 0.21 11.5 5.6 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain zf-C3HC4 PF00097.25 ETN97628.1 - 0.16 11.9 0.8 0.29 11.0 0.8 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) BUD22 PF09073.10 ETN97628.1 - 0.85 8.9 10.9 0.93 8.8 10.9 1.1 1 0 0 1 1 1 0 BUD22 Corazonin PF17308.2 ETN97630.1 - 0.02 15.3 2.2 0.032 14.6 2.2 1.3 1 0 0 1 1 1 0 Pro-corazonin RVT_1 PF00078.27 ETN97632.1 - 0.0013 18.3 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Pet20 PF08692.10 ETN97633.1 - 0.035 14.8 3.3 0.048 14.4 3.3 1.3 1 0 0 1 1 1 0 Mitochondrial protein Pet20 Spt20 PF12090.8 ETN97633.1 - 0.038 13.6 37.3 0.048 13.3 37.3 1.1 1 0 0 1 1 1 0 Spt20 family USP8_interact PF08941.10 ETN97633.1 - 0.056 13.3 10.1 0.062 13.1 10.1 1.1 1 0 0 1 1 1 0 USP8 interacting MAP65_ASE1 PF03999.12 ETN97633.1 - 0.063 12.0 14.0 0.068 11.9 14.0 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DDHD PF02862.17 ETN97633.1 - 0.092 12.9 5.5 0.094 12.9 5.5 1.1 1 0 0 1 1 1 0 DDHD domain MMR1 PF08505.10 ETN97633.1 - 0.1 12.9 15.1 0.12 12.7 15.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein EPL1 PF10513.9 ETN97633.1 - 0.12 12.7 9.0 0.13 12.6 9.0 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Tim54 PF11711.8 ETN97633.1 - 0.13 11.0 8.2 0.15 10.9 8.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM150 PF15129.6 ETN97633.1 - 0.31 11.2 7.5 0.35 11.0 7.5 1.2 1 0 0 1 1 1 0 FAM150 family SpoIIP PF07454.11 ETN97633.1 - 0.46 9.9 9.2 0.49 9.8 9.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) ABC2_membrane_2 PF12679.7 ETN97633.1 - 0.46 9.7 2.3 0.41 9.9 2.3 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein PAT1 PF09770.9 ETN97633.1 - 0.5 8.6 24.3 0.53 8.5 24.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF702 PF05142.12 ETN97633.1 - 0.88 10.0 10.8 1.2 9.6 10.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF702) MPM1 PF17234.2 ETN97633.1 - 1.1 9.6 12.4 1.4 9.2 12.4 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 RAB3GAP2_N PF14655.6 ETN97633.1 - 1.1 8.5 9.3 1.3 8.2 9.3 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4770 PF15994.5 ETN97633.1 - 1.1 9.5 12.8 1.3 9.2 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) CPSF100_C PF13299.6 ETN97633.1 - 1.1 9.4 10.6 1.4 9.1 10.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal eIF-3_zeta PF05091.12 ETN97633.1 - 1.2 8.0 14.6 1.3 7.9 14.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) TERB2 PF15101.6 ETN97633.1 - 1.2 9.1 18.9 1.5 8.8 18.9 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 NST1 PF13945.6 ETN97633.1 - 1.4 9.0 19.1 1.7 8.7 19.1 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator GREB1 PF15782.5 ETN97633.1 - 1.7 5.7 13.5 1.8 5.6 13.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SLC12 PF03522.15 ETN97633.1 - 1.8 7.5 10.9 1.9 7.5 10.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 TraV PF09676.10 ETN97633.1 - 1.9 9.5 12.6 2.8 8.9 12.6 1.3 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) EMC3_TMCO1 PF01956.16 ETN97633.1 - 2 8.1 9.3 2.2 8.0 9.3 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ALMT PF11744.8 ETN97633.1 - 2.3 7.0 8.6 2.4 6.9 8.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 ETN97633.1 - 2.4 7.6 7.5 2.7 7.5 7.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 VIT1 PF01988.19 ETN97633.1 - 2.9 7.7 4.4 3.1 7.6 4.4 1.1 1 0 0 1 1 1 0 VIT family Presenilin PF01080.17 ETN97633.1 - 3.1 6.5 13.3 3.4 6.4 13.3 1.0 1 0 0 1 1 1 0 Presenilin Gti1_Pac2 PF09729.9 ETN97633.1 - 3.2 7.8 8.5 3.6 7.6 8.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Plasmodium_Vir PF05795.11 ETN97633.1 - 3.9 6.8 5.4 4.1 6.7 5.4 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein DUF4199 PF13858.6 ETN97633.1 - 4.3 7.7 7.0 4.9 7.5 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) PepSY_TM PF03929.16 ETN97633.1 - 4.4 6.9 7.0 4.5 6.9 7.0 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Membralin PF09746.9 ETN97633.1 - 4.4 6.2 6.4 4.7 6.2 6.4 1.0 1 0 0 1 1 1 0 Tumour-associated protein EIF4E-T PF10477.9 ETN97633.1 - 4.6 5.9 27.6 5.8 5.6 27.6 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E Med15 PF09606.10 ETN97633.1 - 4.9 5.7 39.8 5.9 5.4 39.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Connexin PF00029.19 ETN97633.1 - 5 6.8 7.2 6.1 6.5 7.2 1.1 1 0 0 1 1 1 0 Connexin Ctr PF04145.15 ETN97633.1 - 5.7 7.6 6.0 6.1 7.5 6.0 1.2 1 0 0 1 1 1 0 Ctr copper transporter family CLN3 PF02487.17 ETN97633.1 - 6.3 5.7 9.1 6.7 5.6 9.1 1.1 1 0 0 1 1 1 0 CLN3 protein V_ATPase_I PF01496.19 ETN97633.1 - 6.3 4.6 10.9 6.8 4.5 10.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rrn6 PF10214.9 ETN97633.1 - 6.8 5.1 28.4 7.4 4.9 28.4 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Ndc1_Nup PF09531.10 ETN97633.1 - 7.6 5.1 15.5 7.5 5.1 15.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Band_3_cyto PF07565.13 ETN97633.1 - 7.8 6.2 11.4 8.8 6.0 11.4 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain CSG2 PF16965.5 ETN97633.1 - 9.3 5.1 5.6 10 4.9 5.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Neur_chan_memb PF02932.16 ETN97633.1 - 9.9 6.1 9.8 10 6.1 9.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HEAT PF02985.22 ETN97634.1 - 6.8e-11 41.5 0.0 0.044 14.1 0.0 3.5 3 0 0 3 3 3 3 HEAT repeat HEAT_2 PF13646.6 ETN97634.1 - 1.2e-05 25.6 0.0 0.012 15.9 0.0 2.4 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 ETN97634.1 - 0.00031 21.2 0.0 0.019 15.5 0.0 3.1 2 1 2 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETN97634.1 - 0.00057 20.4 0.3 0.21 12.2 0.0 2.6 1 1 2 3 3 3 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETN97634.1 - 0.0014 18.7 1.8 0.0022 18.1 0.5 2.0 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 ETN97634.1 - 0.015 14.4 0.8 3.4 6.7 0.1 2.3 1 1 1 2 2 2 0 Interferon-related developmental regulator (IFRD) RsfS PF02410.15 ETN97634.1 - 0.055 13.9 0.3 0.66 10.4 0.3 2.5 1 1 0 1 1 1 0 Ribosomal silencing factor during starvation TAN PF11640.8 ETN97634.1 - 0.1 12.7 2.8 0.12 12.5 0.6 2.3 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair GhoS PF11080.8 ETN97634.1 - 0.11 12.5 0.0 0.7 9.9 0.0 2.2 1 1 1 2 2 2 0 Endoribonuclease GhoS NLE PF08154.12 ETN97634.1 - 0.72 10.4 6.1 21 5.7 0.1 4.0 1 1 3 4 4 4 0 NLE (NUC135) domain tRNA-synt_1 PF00133.22 ETN97635.1 - 1.5e-09 36.7 0.0 1.7e-09 36.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETN97635.1 - 1.7e-08 33.7 0.0 1.9e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (M) PH_3 PF14593.6 ETN97636.1 - 0.016 15.3 0.3 0.054 13.6 0.0 1.9 2 0 0 2 2 2 0 PH domain PH PF00169.29 ETN97636.1 - 0.93 10.0 3.7 0.65 10.5 0.3 2.2 2 1 0 2 2 2 0 PH domain Vps53_N PF04100.12 ETN97637.1 - 0.0028 16.7 0.3 0.0066 15.5 0.0 1.7 2 0 0 2 2 2 1 Vps53-like, N-terminal Ferritin PF00210.24 ETN97638.1 - 0.0071 16.3 0.1 0.2 11.6 0.1 2.5 2 0 0 2 2 2 1 Ferritin-like domain Med7 PF05983.11 ETN97638.1 - 0.041 14.0 0.5 0.14 12.2 0.1 2.1 2 0 0 2 2 2 0 MED7 protein Cyanate_lyase PF02560.14 ETN97638.1 - 0.049 13.5 0.0 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Cyanate lyase C-terminal domain TMEM189_B_dmain PF10520.9 ETN97638.1 - 0.059 13.5 0.7 0.12 12.5 0.3 1.8 2 0 0 2 2 2 0 B domain of TMEM189, localisation domain HAD_2 PF13419.6 ETN97639.1 - 1.3e-08 35.2 0.0 3e-08 34.0 0.0 1.8 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETN97639.1 - 0.00023 21.5 0.0 0.00064 20.1 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETN97639.1 - 0.0042 17.1 0.0 0.011 15.8 0.0 1.6 1 0 0 1 1 1 1 HAD-hyrolase-like Na_H_antiport_3 PF07399.11 ETN97639.1 - 0.13 11.1 0.0 0.21 10.4 0.0 1.2 1 0 0 1 1 1 0 Putative Na+/H+ antiporter Adeno_terminal PF02459.15 ETN97640.1 - 0.037 12.4 1.8 0.042 12.3 1.8 1.1 1 0 0 1 1 1 0 Adenoviral DNA terminal protein DUF1484 PF07363.11 ETN97641.1 - 0.054 14.5 0.2 0.14 13.2 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1484) DUF3046 PF11248.8 ETN97642.1 - 0.015 15.6 0.1 0.047 14.1 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3046) AlcCBM31 PF11606.8 ETN97642.1 - 0.038 14.2 0.1 0.064 13.4 0.1 1.4 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein RTT107_BRCT_5 PF16770.5 ETN97643.1 - 0.0026 17.6 0.3 0.0053 16.6 0.3 1.5 1 0 0 1 1 1 1 Regulator of Ty1 transposition protein 107 BRCT domain Inj_translocase PF16928.5 ETN97643.1 - 0.037 13.5 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome Ndufs5 PF10200.9 ETN97644.1 - 0.0095 16.2 1.3 0.01 16.1 1.3 1.1 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa Chromo_shadow PF01393.19 ETN97644.1 - 1.3 9.2 7.9 3.9 7.7 0.8 2.3 1 1 1 2 2 2 0 Chromo shadow domain PX PF00787.24 ETN97645.1 - 3e-07 30.4 0.3 4.4e-07 29.9 0.3 1.3 1 0 0 1 1 1 1 PX domain Nbl1_Borealin_N PF10444.9 ETN97647.1 - 0.039 13.6 0.5 0.16 11.7 0.4 1.9 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal DUF3942 PF13078.6 ETN97648.1 - 0.026 14.8 0.5 0.039 14.3 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3942) Glyco_hydro_88 PF07470.13 ETN97648.1 - 0.043 12.9 1.8 0.055 12.6 1.8 1.2 1 0 0 1 1 1 0 Glycosyl Hydrolase Family 88 Glyco_transf_49 PF13896.6 ETN97649.1 - 1.3e-27 97.1 0.1 4.1e-27 95.4 0.1 1.7 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 ETN97649.1 - 4.9e-05 23.2 0.0 0.00011 22.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ETN97649.1 - 0.0018 17.8 0.0 0.0046 16.5 0.0 1.6 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ETN97649.1 - 0.11 13.0 0.0 0.21 12.1 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 N6_N4_Mtase PF01555.18 ETN97650.1 - 0.0069 16.1 0.0 0.01 15.6 0.0 1.4 1 1 0 1 1 1 1 DNA methylase Rib_5-P_isom_A PF06026.14 ETN97650.1 - 0.05 13.2 0.6 0.078 12.6 0.6 1.2 1 0 0 1 1 1 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) INCENP_ARK-bind PF03941.15 ETN97650.1 - 0.062 13.2 1.7 0.16 11.9 1.7 1.7 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region TLD PF07534.16 ETN97651.1 - 7.1e-22 78.1 1.4 9.8e-22 77.7 1.4 1.2 1 0 0 1 1 1 1 TLD zf-TRAF PF02176.18 ETN97652.1 - 0.00011 22.8 7.2 0.00011 22.8 7.2 1.9 2 0 0 2 2 2 1 TRAF-type zinc finger YabA PF06156.13 ETN97652.1 - 0.0093 16.6 1.6 0.0093 16.6 1.6 3.2 3 0 0 3 3 3 1 Initiation control protein YabA DUF641 PF04859.12 ETN97652.1 - 0.16 12.3 15.9 0.45 10.9 2.0 2.9 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) DUF1192 PF06698.11 ETN97652.1 - 0.33 11.1 5.9 13 6.0 0.0 3.4 2 1 0 3 3 3 0 Protein of unknown function (DUF1192) Bap31_Bap29_C PF18035.1 ETN97652.1 - 1 9.4 22.7 1.8 8.7 7.0 2.9 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain FapA PF03961.13 ETN97652.1 - 1.8 7.1 26.6 3.9 6.0 12.7 2.2 1 1 1 2 2 2 0 Flagellar Assembly Protein A GvpL_GvpF PF06386.11 ETN97652.1 - 8.6 6.2 8.3 8.1 6.3 0.9 2.5 3 0 0 3 3 3 0 Gas vesicle synthesis protein GvpL/GvpF Gly-zipper_Omp PF13488.6 ETN97653.1 - 1.1e-16 60.5 76.8 0.0012 18.8 11.4 7.0 1 1 6 7 7 7 7 Glycine zipper Gly-zipper_YMGG PF13441.6 ETN97653.1 - 3.8e-10 39.3 53.9 1.8e+04 -30.4 53.9 7.2 1 1 0 1 1 1 0 YMGG-like Gly-zipper AAA_8 PF12780.7 ETN97655.1 - 0.0019 17.6 1.2 0.0041 16.5 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA PF00004.29 ETN97655.1 - 0.0026 18.2 0.2 0.011 16.1 0.0 2.2 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_15 PF13175.6 ETN97655.1 - 0.0052 16.5 1.8 0.0064 16.2 1.0 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETN97655.1 - 0.02 15.2 0.0 0.076 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 ETN97655.1 - 0.052 12.6 0.0 0.089 11.9 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain PduV-EutP PF10662.9 ETN97655.1 - 0.061 13.1 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MTS_N PF08468.11 ETN97655.1 - 0.064 13.3 1.2 0.11 12.6 0.0 1.9 2 1 0 2 2 2 0 Methyltransferase small domain N-terminal ABC_tran PF00005.27 ETN97655.1 - 0.071 13.6 1.5 0.13 12.8 0.5 2.2 2 1 0 2 2 2 0 ABC transporter AAA_5 PF07728.14 ETN97655.1 - 0.073 13.1 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ATP-synt_ab PF00006.25 ETN97655.1 - 0.084 12.5 0.1 0.23 11.1 0.2 1.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_23 PF13476.6 ETN97655.1 - 0.26 11.7 6.5 1.4 9.4 0.2 2.7 2 1 1 3 3 3 0 AAA domain Phage_portal PF04860.12 ETN97656.1 - 0.013 14.8 0.2 0.019 14.2 0.1 1.3 1 1 0 1 1 1 0 Phage portal protein SPOUT_MTase PF02590.17 ETN97656.1 - 0.018 15.1 1.2 0.02 14.8 1.2 1.1 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase HTH_25 PF13413.6 ETN97656.1 - 0.019 14.8 0.1 0.045 13.6 0.1 1.6 1 1 0 1 1 1 0 Helix-turn-helix domain HTH_15 PF12324.8 ETN97656.1 - 0.058 13.3 0.3 0.17 11.9 0.2 1.8 2 0 0 2 2 2 0 Helix-turn-helix domain of alkylmercury lyase Tristanin_u2 PF16638.5 ETN97656.1 - 0.16 12.8 2.3 0.22 12.3 2.3 1.3 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Lipoprotein_20 PF13942.6 ETN97657.1 - 0.086 12.8 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 YfhG lipoprotein ThiP_synth PF10120.9 ETN97658.1 - 0.06 13.0 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Thiamine-phosphate synthase FLgD_tudor PF13861.6 ETN97659.1 - 0.029 14.6 0.0 0.068 13.4 0.0 2.0 1 1 0 1 1 1 0 FlgD Tudor-like domain SIT PF15330.6 ETN97659.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.6 1 1 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT PKD PF00801.20 ETN97660.1 - 0.022 14.6 0.2 0.052 13.4 0.2 1.6 1 0 0 1 1 1 0 PKD domain Toxin_ToxA PF11584.8 ETN97663.1 - 0.068 13.2 0.1 0.1 12.6 0.1 1.4 1 0 0 1 1 1 0 Proteinaceous host-selective toxin ToxA YqaJ PF09588.10 ETN97664.1 - 0.018 15.2 0.3 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 YqaJ-like viral recombinase domain Pkinase PF00069.25 ETN97665.1 - 9.4e-38 130.1 0.0 1.4e-37 129.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN97665.1 - 3.2e-15 56.1 0.0 7e-15 55.0 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETN97665.1 - 0.012 15.5 0.2 0.02 14.8 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family HSP70 PF00012.20 ETN97666.1 - 0.021 13.0 0.0 0.2 9.8 0.0 2.1 2 0 0 2 2 2 0 Hsp70 protein Pkinase PF00069.25 ETN97667.1 - 2.5e-13 50.0 0.3 6.2e-07 29.0 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETN97667.1 - 4.6e-05 22.8 0.2 0.0059 15.9 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETN97669.1 - 4.6e-19 68.8 0.0 7.2e-19 68.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN97669.1 - 0.00013 21.4 0.0 0.00029 20.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase GAS PF13851.6 ETN97669.1 - 0.012 15.0 0.4 0.016 14.5 0.4 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding ESAG1 PF03238.13 ETN97669.1 - 0.021 14.3 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 ESAG protein CAP_GLY PF01302.25 ETN97670.1 - 4.5e-05 23.4 1.7 0.00042 20.3 1.7 2.4 1 1 0 1 1 1 1 CAP-Gly domain FUR PF01475.19 ETN97671.1 - 0.073 13.2 0.0 0.082 13.0 0.0 1.1 1 0 0 1 1 1 0 Ferric uptake regulator family TMEM132D_C PF15706.5 ETN97672.1 - 5.7 6.8 0.0 5.7 6.8 0.0 4.0 5 0 0 5 5 5 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Dopey_N PF04118.14 ETN97673.1 - 8.8e-06 25.0 1.0 2.3e-05 23.7 1.0 2.1 1 1 0 1 1 1 1 Dopey, N-terminal HEAT_2 PF13646.6 ETN97673.1 - 9.7e-05 22.7 0.0 0.51 10.8 0.0 2.7 2 1 0 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETN97673.1 - 0.00053 20.1 0.7 0.17 12.0 0.2 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETN97673.1 - 0.018 15.2 0.1 15 6.1 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat TetR_C_13 PF16925.5 ETN97673.1 - 0.024 14.6 1.6 0.27 11.2 0.6 2.5 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain HEAT_EZ PF13513.6 ETN97673.1 - 0.11 13.0 0.0 36 5.0 0.0 3.1 3 0 0 3 3 3 0 HEAT-like repeat Syntaxin-6_N PF09177.11 ETN97674.1 - 0.36 11.4 2.7 0.48 11.0 1.2 1.9 2 0 0 2 2 2 0 Syntaxin 6, N-terminal NACHT PF05729.12 ETN97675.1 - 1.5e-19 70.5 0.0 2.7e-19 69.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETN97675.1 - 0.00023 21.6 0.0 0.00059 20.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 ETN97675.1 - 0.0028 16.9 4.0 0.03 13.5 0.1 2.7 2 1 0 2 2 2 1 NB-ARC domain THDPS_N PF14790.6 ETN97675.1 - 0.0047 16.8 0.4 0.015 15.1 0.4 1.8 1 0 0 1 1 1 1 Tetrahydrodipicolinate N-succinyltransferase N-terminal NLRC4_HD2 PF17776.1 ETN97675.1 - 0.12 13.0 0.1 0.12 13.0 0.1 4.0 4 1 1 5 5 5 0 NLRC4 helical domain HD2 ABC_tran PF00005.27 ETN97675.1 - 0.23 12.0 2.1 1.2 9.7 0.0 2.8 3 0 0 3 3 3 0 ABC transporter TRAP_alpha PF03896.16 ETN97675.1 - 0.52 9.5 7.8 1 8.5 7.8 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4820 PF16091.5 ETN97675.1 - 1 8.7 9.2 2 7.7 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DNA_pol_phi PF04931.13 ETN97675.1 - 1.1 7.3 16.8 2.3 6.2 16.8 1.5 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETN97675.1 - 1.2 7.8 12.5 1.8 7.2 12.5 1.2 1 0 0 1 1 1 0 Presenilin RPN2_C PF18004.1 ETN97675.1 - 1.4 8.9 18.3 0.13 12.1 10.3 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain CTU2 PF10288.9 ETN97675.1 - 1.5 9.1 10.2 2.6 8.3 9.4 1.7 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 MID_MedPIWI PF18296.1 ETN97675.1 - 2.8 7.7 10.3 1.1 8.9 7.5 1.7 2 0 0 2 2 2 0 MID domain of medPIWI CENP-T_N PF16171.5 ETN97675.1 - 5.7 5.7 6.3 8.3 5.2 6.3 1.1 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T N-terminus Neur_chan_memb PF02932.16 ETN97675.1 - 7.7 6.5 6.6 13 5.8 6.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RPA43_OB PF17875.1 ETN97675.1 - 8.1 7.1 14.7 0.32 11.6 7.3 2.4 3 0 0 3 3 2 0 RPA43 OB domain in RNA Pol I DDHD PF02862.17 ETN97675.1 - 9.6 6.3 12.3 10 6.2 10.9 1.6 1 1 0 2 2 2 0 DDHD domain NOA36 PF06524.12 ETN97675.1 - 9.8 5.4 14.8 15 4.8 14.8 1.3 1 0 0 1 1 1 0 NOA36 protein RdRP PF05183.12 ETN97678.1 - 0.0014 17.4 0.4 0.0017 17.1 0.0 1.4 2 0 0 2 2 2 1 RNA dependent RNA polymerase NuDC PF16273.5 ETN97678.1 - 0.45 11.1 4.7 0.17 12.5 1.5 1.8 2 0 0 2 2 2 0 Nuclear distribution C domain CH PF00307.31 ETN97679.1 - 1.5e-20 73.4 0.7 2.2e-12 47.1 0.2 2.1 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETN97679.1 - 0.00052 19.8 0.0 0.00099 18.9 0.0 1.4 1 0 0 1 1 1 1 CAMSAP CH domain DivIVA PF05103.13 ETN97680.1 - 0.0076 16.3 4.7 0.18 11.9 0.1 2.4 2 0 0 2 2 2 2 DivIVA protein Med12 PF09497.10 ETN97680.1 - 0.061 13.6 0.3 0.6 10.4 0.0 2.6 3 0 0 3 3 3 0 Transcription mediator complex subunit Med12 PI_PP_I PF18363.1 ETN97680.1 - 0.18 12.0 11.4 1.7 8.9 2.0 2.8 1 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain Mod_r PF07200.13 ETN97680.1 - 0.44 10.6 9.2 0.44 10.6 5.9 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein APG6_N PF17675.1 ETN97680.1 - 1.2 9.6 5.4 2.3 8.8 5.4 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Fib_alpha PF08702.10 ETN97680.1 - 5.8 7.1 9.2 5.8 7.1 4.2 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF4746 PF15928.5 ETN97681.1 - 0.1 12.0 4.7 0.13 11.6 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 ETN97681.1 - 2.4 6.8 6.2 2.7 6.7 6.2 1.1 1 0 0 1 1 1 0 Presenilin Lipoprotein_15 PF03640.15 ETN97683.1 - 0.054 13.1 0.2 0.12 12.0 0.2 1.5 1 0 0 1 1 1 0 Secreted repeat of unknown function DUF5523 PF17661.1 ETN97685.1 - 7.5 6.2 34.7 8.6 6.0 34.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF1764 PF08576.10 ETN97687.1 - 0.32 11.9 8.8 0.45 11.4 8.8 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) PIEZO PF15917.5 ETN97687.1 - 0.48 9.9 11.5 0.55 9.7 11.5 1.1 1 0 0 1 1 1 0 Piezo TPR_12 PF13424.6 ETN97688.1 - 2.6e-82 271.1 24.0 1.8e-19 69.8 2.6 7.0 3 3 3 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97688.1 - 5.5e-61 200.9 7.3 2.2e-08 33.7 0.3 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97688.1 - 1.3e-52 173.6 51.6 1.2e-06 28.1 1.7 10.7 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97688.1 - 1.7e-44 146.6 17.5 1.2e-06 28.1 0.2 10.9 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97688.1 - 5e-37 123.0 40.0 0.00028 20.7 1.2 10.6 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97688.1 - 9.9e-32 106.5 55.2 2.2e-05 24.3 0.3 10.6 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97688.1 - 1.4e-11 43.9 17.6 0.11 12.9 0.0 9.8 7 2 2 9 9 9 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN97688.1 - 1.1e-10 41.4 0.0 0.00011 21.7 0.0 2.7 1 1 2 3 3 3 2 MalT-like TPR region DUF5113 PF17140.4 ETN97688.1 - 4.4e-10 39.6 24.7 0.81 9.5 1.7 8.3 8 0 0 8 8 8 3 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETN97688.1 - 9.3e-10 39.0 0.1 4.7 8.0 0.0 7.0 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97688.1 - 7.4e-09 35.7 0.0 16 6.7 0.0 7.5 8 0 0 8 8 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97688.1 - 1.3e-08 34.9 12.5 14 6.6 0.0 9.0 10 0 0 10 10 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN97688.1 - 5.5e-06 26.5 23.6 0.0066 16.6 4.0 5.7 3 1 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETN97688.1 - 5.7e-06 25.9 50.7 0.15 11.8 0.2 11.7 10 4 4 14 14 13 3 TPR repeat PPR PF01535.20 ETN97688.1 - 2.4e-05 24.3 9.3 0.61 10.5 0.0 6.3 5 0 0 5 5 5 1 PPR repeat TPR_3 PF07720.12 ETN97688.1 - 0.00024 21.0 29.6 0.032 14.2 1.6 6.4 6 0 0 6 6 5 2 Tetratricopeptide repeat DUF3856 PF12968.7 ETN97688.1 - 0.002 18.2 11.5 0.14 12.2 0.3 5.0 1 1 5 6 6 6 1 Domain of Unknown Function (DUF3856) TPR_19 PF14559.6 ETN97688.1 - 0.0021 18.5 5.5 1.2 9.7 0.1 4.9 3 2 1 5 5 5 1 Tetratricopeptide repeat Endonuclease_1 PF04231.13 ETN97688.1 - 0.0039 16.9 9.1 0.14 11.8 1.0 2.4 2 1 0 2 2 2 2 Endonuclease I SPO22 PF08631.10 ETN97688.1 - 0.0069 15.9 14.8 1.5 8.2 0.7 5.0 2 2 3 5 5 5 2 Meiosis protein SPO22/ZIP4 like HisG PF01634.18 ETN97688.1 - 0.0087 16.0 1.3 3.3 7.6 0.0 3.7 2 2 2 4 4 4 1 ATP phosphoribosyltransferase Fis1_TPR_C PF14853.6 ETN97688.1 - 0.015 15.3 34.7 0.15 12.2 0.5 8.9 9 1 1 10 10 10 0 Fis1 C-terminal tetratricopeptide repeat NRBF2_MIT PF17169.4 ETN97688.1 - 0.019 15.2 11.3 9.2 6.6 0.1 5.6 4 2 2 6 6 6 0 MIT domain of nuclear receptor-binding factor 2 TBK1_CCD1 PF18394.1 ETN97688.1 - 0.024 14.2 0.1 1.1 8.7 0.0 2.5 2 1 0 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 DUF2977 PF11192.8 ETN97688.1 - 0.028 14.5 0.0 26 5.1 0.0 3.8 4 0 0 4 4 3 0 Protein of unknown function (DUF2977) DUF627 PF04781.12 ETN97688.1 - 0.054 13.5 15.2 2.9 8.0 0.1 6.2 3 2 3 6 6 6 0 Protein of unknown function (DUF627) SPAN-X PF07458.12 ETN97688.1 - 0.16 12.4 6.4 32 5.1 0.1 4.6 5 1 0 5 5 4 0 Sperm protein associated with nucleus, mapped to X chromosome FATC PF02260.20 ETN97688.1 - 0.2 11.5 0.0 12 5.9 0.0 2.7 3 0 0 3 3 2 0 FATC domain DUF357 PF04010.13 ETN97688.1 - 0.74 9.9 16.8 3 8.0 0.0 5.8 4 1 4 8 8 6 0 Protein of unknown function (DUF357) SHNi-TPR PF10516.9 ETN97688.1 - 1.4 8.5 8.2 40 3.8 0.0 5.9 7 0 0 7 7 5 0 SHNi-TPR HTH_Bact PF18768.1 ETN97688.1 - 1.4 8.5 33.1 13 5.4 2.0 9.8 7 3 2 9 9 9 0 Helix-turn-helix bacterial domain DUF3568 PF12092.8 ETN97688.1 - 2.9 8.0 8.5 4.8 7.3 0.2 4.5 1 1 3 5 5 5 0 Protein of unknown function (DUF3568) MIT PF04212.18 ETN97688.1 - 4.7 7.4 31.8 12 6.1 0.1 8.0 6 1 2 8 8 8 0 MIT (microtubule interacting and transport) domain Prefoldin PF02996.17 ETN97688.1 - 7.4 6.5 11.7 12 5.8 0.3 4.4 3 1 1 4 4 4 0 Prefoldin subunit RadC PF04002.15 ETN97689.1 - 0.68 9.9 4.2 2.3 8.2 0.2 2.8 1 1 2 3 3 3 0 RadC-like JAB domain Kelch_5 PF13854.6 ETN97690.1 - 0.0022 17.9 0.3 0.023 14.7 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN97690.1 - 0.011 16.0 0.4 3.3 8.2 0.2 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETN97690.1 - 0.014 15.3 0.2 0.66 10.0 0.3 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETN97690.1 - 0.032 13.8 1.1 0.081 12.5 0.4 2.0 2 1 0 2 2 2 0 Kelch motif PC4 PF02229.16 ETN97690.1 - 0.036 13.7 1.0 0.067 12.8 0.4 1.7 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) Kelch_4 PF13418.6 ETN97690.1 - 0.05 13.6 0.3 0.32 11.0 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain BSD PF03909.17 ETN97692.1 - 0.043 13.8 1.6 4.6 7.3 0.0 3.3 4 1 0 4 4 4 0 BSD domain PBP_dimer PF03717.15 ETN97692.1 - 0.38 11.1 4.3 0.53 10.6 4.3 1.4 1 1 0 1 1 1 0 Penicillin-binding Protein dimerisation domain RMI1_C PF16099.5 ETN97693.1 - 0.0038 17.1 0.1 0.093 12.6 0.1 2.3 1 1 0 1 1 1 1 Recq-mediated genome instability protein 1, C-terminal OB-fold HEPN_Swt1 PF18731.1 ETN97693.1 - 0.13 12.7 0.9 0.21 11.9 0.6 1.6 1 1 0 1 1 1 0 Swt1-like HEPN Ank_4 PF13637.6 ETN97694.1 - 2.5e-08 34.3 1.6 1.4e-05 25.6 0.5 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETN97694.1 - 7.7e-08 32.8 2.7 3e-06 27.7 1.3 2.7 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETN97694.1 - 1.3e-05 25.4 2.2 0.3 11.6 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ETN97694.1 - 2.5e-05 24.3 1.5 2.2 9.1 0.1 4.2 4 0 0 4 4 4 1 Ankyrin repeat O_anti_polymase PF01901.16 ETN97694.1 - 0.00072 18.9 0.1 0.00098 18.5 0.1 1.2 1 0 0 1 1 1 1 Putative O-antigen polymerase Ank_5 PF13857.6 ETN97694.1 - 0.0088 16.3 2.1 0.63 10.4 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETN97695.1 - 8.1e-08 32.7 0.0 0.0027 18.2 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETN97695.1 - 3.5e-06 27.2 0.1 0.023 15.1 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_3 PF13606.6 ETN97695.1 - 1.7e-05 24.8 0.4 0.85 10.4 0.0 4.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETN97695.1 - 0.0018 18.5 0.3 0.64 10.4 0.0 4.1 3 1 1 4 4 4 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETN97695.1 - 0.0037 17.8 0.1 0.18 12.4 0.0 3.1 2 1 0 2 2 2 1 Ankyrin repeats (many copies) DUF3677 PF12432.8 ETN97696.1 - 0.017 15.4 0.1 0.029 14.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) U1snRNP70_N PF12220.8 ETN97698.1 - 0.93 10.2 8.3 0.29 11.8 4.3 2.0 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Kelch_4 PF13418.6 ETN97700.1 - 0.00049 20.1 0.3 0.16 12.0 0.0 2.8 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN97700.1 - 0.00075 19.7 1.5 18 5.8 0.1 3.9 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETN97700.1 - 0.0026 17.3 0.5 1.1 8.9 0.0 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETN97700.1 - 0.016 15.2 2.8 1.8 8.7 0.1 3.8 4 0 0 4 4 4 0 Kelch motif IL3 PF02059.15 ETN97700.1 - 0.12 12.4 0.1 0.38 10.8 0.1 1.9 1 0 0 1 1 1 0 Interleukin-3 Auxin_canalis PF05703.11 ETN97701.1 - 0.023 14.6 3.1 0.03 14.3 3.1 1.1 1 0 0 1 1 1 0 Auxin canalisation TetR_C_26 PF17934.1 ETN97701.1 - 0.55 10.6 4.2 6.8 7.1 0.5 2.5 1 1 2 3 3 3 0 Tetracyclin repressor-like, C-terminal domain LAMTOR PF15454.6 ETN97701.1 - 0.74 10.5 4.5 0.45 11.2 1.1 2.1 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator DUF4407 PF14362.6 ETN97701.1 - 1.2 8.4 4.6 1.4 8.2 4.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 ETN97701.1 - 2.8 6.8 6.6 2.9 6.7 6.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein UN_NPL4 PF11543.8 ETN97702.1 - 0.14 12.7 0.0 0.39 11.2 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Choline_sulf_C PF12411.8 ETN97702.1 - 0.55 10.1 2.9 3.2 7.6 0.4 2.4 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal WD40 PF00400.32 ETN97703.1 - 3.5e-68 223.8 15.4 3.8e-11 43.4 0.0 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97703.1 - 7.8e-20 71.0 0.1 0.0054 17.0 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN97703.1 - 6.7e-16 58.2 0.4 0.002 17.2 0.0 6.5 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETN97703.1 - 1.4e-09 38.2 0.0 0.00028 20.8 0.0 3.6 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETN97703.1 - 7.7e-09 35.3 0.1 0.0024 17.3 0.1 3.3 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETN97703.1 - 8e-07 28.8 11.1 3.8 7.6 0.1 6.9 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETN97703.1 - 4.3e-05 22.2 0.3 0.0059 15.2 0.0 2.3 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETN97703.1 - 9.6e-05 21.2 3.2 1.4 7.5 0.0 4.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETN97703.1 - 0.00012 21.3 0.0 0.14 11.2 0.0 2.5 1 1 1 2 2 2 2 Coatomer WD associated region Nbas_N PF15492.6 ETN97703.1 - 0.0011 18.4 0.4 1.4 8.1 0.1 3.1 1 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Me-amine-dh_H PF06433.11 ETN97703.1 - 0.026 13.4 0.0 0.1 11.4 0.0 1.9 1 1 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Proteasome_A_N PF10584.9 ETN97703.1 - 0.038 13.7 2.6 59 3.5 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF2963 PF11178.8 ETN97703.1 - 0.09 12.5 0.0 14 5.5 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF2963) DPPIV_N PF00930.21 ETN97703.1 - 0.11 11.2 0.1 5.4 5.7 0.0 3.0 3 1 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cys_rich_VLP PF14194.6 ETN97704.1 - 0.00069 19.7 2.2 0.0012 18.9 2.2 1.5 1 0 0 1 1 1 1 Cysteine-rich VLP Peptidase_C1 PF00112.23 ETN97707.1 - 4.3e-55 187.2 5.3 4.7e-55 187.0 5.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ETN97707.1 - 0.00065 18.6 0.2 0.00091 18.1 0.2 1.1 1 0 0 1 1 1 1 Peptidase C1-like family MTHFR_C PF12225.8 ETN97707.1 - 0.045 13.4 2.5 2.7 7.7 0.2 2.6 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal SirB PF04247.12 ETN97708.1 - 0.029 14.4 10.2 0.28 11.3 8.6 2.2 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB Polysacc_synt_C PF14667.6 ETN97708.1 - 2 8.5 18.6 0.22 11.6 7.2 2.3 1 1 0 2 2 2 0 Polysaccharide biosynthesis C-terminal domain DUF3270 PF11674.8 ETN97710.1 - 0.18 12.0 2.0 0.28 11.4 2.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3270) zf-TRAF PF02176.18 ETN97711.1 - 1.7e-06 28.6 2.1 4.8e-06 27.2 2.1 1.8 1 0 0 1 1 1 1 TRAF-type zinc finger FAM76 PF16046.5 ETN97711.1 - 0.28 10.5 32.2 2.2 7.6 31.0 2.0 1 1 1 2 2 2 0 FAM76 protein Muted PF14942.6 ETN97711.1 - 3.1 8.1 33.4 9.3 6.6 17.4 2.2 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein TPR_12 PF13424.6 ETN97713.1 - 2.3e-20 72.6 0.7 3.8e-20 71.9 0.7 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97713.1 - 1.5e-19 68.9 10.2 1.2e-09 37.5 0.7 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97713.1 - 5e-18 64.4 0.1 2.4e-08 33.6 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97713.1 - 3.9e-16 57.8 5.7 1.8e-07 30.7 1.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97713.1 - 4e-16 57.8 8.2 3.7e-08 33.0 0.5 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97713.1 - 8.9e-16 56.7 0.3 1.2e-07 31.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97713.1 - 1.2e-09 37.7 8.2 2e-05 24.2 1.1 3.5 2 2 2 4 4 4 2 TPR repeat TPR_17 PF13431.6 ETN97713.1 - 1.5e-06 28.2 2.9 0.0016 18.7 0.5 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETN97713.1 - 5e-06 26.4 2.5 0.0063 16.5 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97713.1 - 8.2e-06 26.1 0.5 0.03 15.0 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97713.1 - 0.00012 22.7 0.0 0.0027 18.3 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 ETN97713.1 - 0.00022 21.2 6.3 0.19 11.8 0.8 2.6 1 1 1 2 2 2 2 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETN97713.1 - 0.00026 20.3 0.0 0.19 11.2 0.0 2.5 2 0 0 2 2 2 2 SHNi-TPR SNAP PF14938.6 ETN97713.1 - 0.00053 19.5 1.1 0.0009 18.7 1.1 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETN97713.1 - 0.0013 18.6 3.4 0.26 11.1 0.5 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETN97713.1 - 0.0022 18.7 0.0 2.2 9.3 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97713.1 - 0.0034 17.9 0.3 0.55 10.8 0.1 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF3856 PF12968.7 ETN97713.1 - 0.009 16.1 0.5 0.049 13.7 0.2 2.2 2 1 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_MalT PF17874.1 ETN97713.1 - 0.075 12.4 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region DUF627 PF04781.12 ETN97713.1 - 0.14 12.2 0.6 1.4 9.0 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF627) FRG1 PF06229.12 ETN97717.1 - 0.16 11.7 11.7 0.27 10.9 11.7 1.3 1 0 0 1 1 1 0 FRG1-like domain AAA_11 PF13086.6 ETN97717.1 - 0.42 10.4 9.7 0.67 9.7 9.7 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETN97717.1 - 1.8 9.0 20.6 0.37 11.3 16.9 1.7 2 0 0 2 2 2 0 AAA domain EMC3_TMCO1 PF01956.16 ETN97717.1 - 6.4 6.5 8.4 13 5.4 8.4 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like WD40 PF00400.32 ETN97718.1 - 2.8e-06 28.0 0.9 6.6e-06 26.8 0.9 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat DUF641 PF04859.12 ETN97718.1 - 0.00057 20.2 13.8 0.078 13.3 3.7 2.5 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) Atg14 PF10186.9 ETN97718.1 - 0.0071 15.5 16.4 0.01 14.9 16.4 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DDHD PF02862.17 ETN97718.1 - 0.017 15.3 7.3 0.022 14.9 7.3 1.1 1 0 0 1 1 1 0 DDHD domain PKcGMP_CC PF16808.5 ETN97718.1 - 0.018 14.9 4.4 0.018 14.9 4.4 3.3 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4177 PF13783.6 ETN97718.1 - 0.029 14.7 2.3 0.034 14.4 0.2 2.4 3 0 0 3 3 2 0 Domain of unknown function (DUF4177) RecC_C PF17946.1 ETN97718.1 - 0.13 12.0 0.2 1.1 9.1 0.1 1.9 2 0 0 2 2 2 0 RecC C-terminal domain Bap31_Bap29_C PF18035.1 ETN97718.1 - 0.3 11.1 20.3 0.17 11.9 6.3 2.6 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain HIP1_clath_bdg PF16515.5 ETN97718.1 - 0.71 10.5 24.0 0.17 12.5 6.8 3.0 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PI3K_p85B PF02192.16 ETN97718.1 - 0.85 9.4 8.0 0.28 10.9 2.2 2.8 2 1 0 3 3 3 0 PI3-kinase family, p85-binding domain zf-TRAF PF02176.18 ETN97718.1 - 1 10.1 4.1 0.32 11.7 0.8 2.0 2 0 0 2 2 2 0 TRAF-type zinc finger DUF1192 PF06698.11 ETN97718.1 - 1 9.5 7.2 13 5.9 0.1 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF1192) YabA PF06156.13 ETN97718.1 - 1.2 9.9 23.3 0.16 12.6 7.1 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Geminin PF07412.12 ETN97718.1 - 1.5 8.5 20.1 0.3 10.8 7.6 3.2 2 2 0 2 2 2 0 Geminin CC2-LZ PF16516.5 ETN97718.1 - 1.5 9.2 20.2 0.55 10.6 5.4 2.4 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF2203 PF09969.9 ETN97718.1 - 2.2 9.0 10.8 2.1 9.1 3.1 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Csm1_N PF18504.1 ETN97718.1 - 2.8 8.4 25.4 5.1 7.5 9.7 3.2 2 1 1 3 3 3 0 Csm1 N-terminal domain GvpL_GvpF PF06386.11 ETN97718.1 - 3.5 7.5 8.5 26 4.6 8.5 1.9 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF TMPIT PF07851.13 ETN97718.1 - 3.8 6.7 24.4 0.66 9.2 11.5 2.1 1 1 1 2 2 2 0 TMPIT-like protein HMMR_N PF15905.5 ETN97718.1 - 4.2 6.7 27.9 1.1 8.7 11.4 2.1 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal SAM_1 PF00536.30 ETN97719.1 - 1.8e-13 50.7 0.3 3e-13 50.0 0.3 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN97719.1 - 1.1e-09 38.2 0.2 1.7e-09 37.7 0.2 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TFIIE_alpha PF02002.17 ETN97719.1 - 0.046 13.6 0.8 0.066 13.1 0.8 1.2 1 0 0 1 1 1 0 TFIIE alpha subunit MRNIP PF15749.5 ETN97721.1 - 0.022 15.5 10.2 4 8.2 0.0 2.4 2 0 0 2 2 2 0 MRN-interacting protein Vfa1 PF08432.10 ETN97721.1 - 0.033 14.5 10.5 0.061 13.7 10.5 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Zip PF02535.22 ETN97721.1 - 0.088 12.0 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4746 PF15928.5 ETN97721.1 - 0.17 11.3 7.4 0.26 10.7 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RPOL_N PF14700.6 ETN97721.1 - 0.17 11.3 7.8 0.27 10.6 7.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal Connexin PF00029.19 ETN97721.1 - 0.55 10.0 2.8 0.82 9.4 2.8 1.4 1 0 0 1 1 1 0 Connexin DUF4208 PF13907.6 ETN97722.1 - 0.035 14.5 0.2 0.062 13.7 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) DUF4795 PF16043.5 ETN97723.1 - 0.0008 19.1 29.3 0.00091 18.9 29.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) TMF_DNA_bd PF12329.8 ETN97723.1 - 0.0038 17.2 18.3 0.0038 17.2 18.3 2.9 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding Atg14 PF10186.9 ETN97723.1 - 0.0042 16.2 24.8 0.007 15.5 24.8 1.4 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 IFT57 PF10498.9 ETN97723.1 - 0.0052 15.8 20.7 0.0052 15.8 20.7 1.6 1 1 1 2 2 2 1 Intra-flagellar transport protein 57 ADIP PF11559.8 ETN97723.1 - 0.0086 16.2 17.0 0.0086 16.2 17.0 2.1 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding SusD-like_3 PF14322.6 ETN97723.1 - 0.012 15.9 2.5 0.012 15.9 2.5 1.6 1 1 1 2 2 2 0 Starch-binding associating with outer membrane CLZ PF16526.5 ETN97723.1 - 0.012 15.9 13.2 0.012 15.9 13.2 2.8 2 1 2 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels KxDL PF10241.9 ETN97723.1 - 0.014 15.6 14.3 0.014 15.6 14.3 2.6 1 1 1 2 2 2 0 Uncharacterized conserved protein DASH_Duo1 PF08651.10 ETN97723.1 - 0.037 13.8 11.6 0.057 13.2 3.3 2.6 1 1 1 2 2 2 0 DASH complex subunit Duo1 AAA_13 PF13166.6 ETN97723.1 - 0.041 12.5 23.1 0.048 12.3 23.1 1.0 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 ETN97723.1 - 0.044 12.7 29.4 0.061 12.2 29.4 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ETN97723.1 - 0.078 13.0 30.3 0.27 11.3 28.5 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3150 PF11348.8 ETN97723.1 - 0.078 12.2 7.8 0.086 12.1 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) HOOK PF05622.12 ETN97723.1 - 0.082 11.0 31.5 0.12 10.6 23.0 2.0 1 1 1 2 2 2 0 HOOK protein FPP PF05911.11 ETN97723.1 - 0.099 10.8 31.3 0.11 10.7 31.3 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil Leu_zip PF15294.6 ETN97723.1 - 0.13 11.7 26.9 0.24 10.9 26.9 1.5 1 1 0 1 1 1 0 Leucine zipper FTCD_C PF04961.12 ETN97723.1 - 0.19 11.4 10.8 0.29 10.9 10.8 1.3 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase FAM184 PF15665.5 ETN97723.1 - 0.22 11.3 27.7 0.99 9.1 21.8 2.1 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B Exonuc_VII_L PF02601.15 ETN97723.1 - 0.26 10.8 18.4 0.3 10.6 18.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit EzrA PF06160.12 ETN97723.1 - 0.3 9.2 23.2 0.51 8.5 23.2 1.4 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Fmp27_WPPW PF10359.9 ETN97723.1 - 0.32 9.8 19.7 0.37 9.6 19.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain KASH_CCD PF14662.6 ETN97723.1 - 0.33 10.8 30.3 0.58 10.0 30.3 1.4 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 ETN97723.1 - 0.33 11.0 20.2 0.05 13.6 8.5 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) YscO PF07321.12 ETN97723.1 - 0.35 10.8 24.3 0.21 11.5 21.4 1.9 1 1 1 2 2 2 0 Type III secretion protein YscO RmuC PF02646.16 ETN97723.1 - 0.4 9.8 20.8 0.047 12.8 11.1 2.0 1 1 1 2 2 2 0 RmuC family DUF3552 PF12072.8 ETN97723.1 - 0.4 10.1 31.6 0.022 14.2 16.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) HAUS-augmin3 PF14932.6 ETN97723.1 - 0.46 10.0 24.4 0.65 9.5 24.4 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 HMMR_N PF15905.5 ETN97723.1 - 0.6 9.5 29.9 0.85 9.0 29.9 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Acyl-CoA_dh_2 PF08028.11 ETN97723.1 - 0.68 10.2 6.1 0.9 9.8 6.0 1.3 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, C-terminal domain Phage_GPO PF05929.11 ETN97723.1 - 0.75 9.4 16.6 0.97 9.0 16.6 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase T3SSipB PF16535.5 ETN97723.1 - 1 9.9 20.9 1.3 9.4 20.9 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB STAT_alpha PF01017.20 ETN97723.1 - 1 9.2 25.0 1.1 9.1 22.5 2.2 1 1 1 2 2 2 0 STAT protein, all-alpha domain Metal_resist PF13801.6 ETN97723.1 - 1 9.6 9.7 0.12 12.6 4.3 1.9 1 1 1 2 2 2 0 Heavy-metal resistance Tropomyosin_1 PF12718.7 ETN97723.1 - 1.1 9.4 31.2 5.8 7.1 31.2 2.0 1 1 0 1 1 1 0 Tropomyosin like FlaC_arch PF05377.11 ETN97723.1 - 1.2 9.6 20.4 2.6 8.5 6.1 3.5 1 1 3 4 4 3 0 Flagella accessory protein C (FlaC) ERM PF00769.19 ETN97723.1 - 1.2 8.8 33.1 3.6 7.4 33.1 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Tweety PF04906.13 ETN97723.1 - 1.4 7.5 8.9 1.5 7.4 8.9 1.2 1 0 0 1 1 1 0 Tweety GAS PF13851.6 ETN97723.1 - 1.4 8.2 33.2 19 4.5 33.2 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF1043 PF06295.12 ETN97723.1 - 1.5 8.9 22.3 0.7 9.9 19.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) TMPIT PF07851.13 ETN97723.1 - 1.6 7.9 23.7 1.6 7.9 19.1 1.7 1 1 0 1 1 1 0 TMPIT-like protein Tup_N PF08581.10 ETN97723.1 - 1.6 9.1 20.3 0.14 12.5 13.3 2.5 1 1 2 3 3 3 0 Tup N-terminal FapA PF03961.13 ETN97723.1 - 1.8 7.1 19.4 2 6.9 19.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TPR_MLP1_2 PF07926.12 ETN97723.1 - 1.9 8.5 33.7 3.8 7.6 20.3 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 ETN97723.1 - 2.1 9.0 24.7 4.5 8.0 5.4 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Jnk-SapK_ap_N PF09744.9 ETN97723.1 - 2.6 8.2 30.7 3 8.0 25.3 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 UPF0184 PF03670.13 ETN97723.1 - 2.7 8.4 11.4 9.9 6.6 0.4 3.2 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0184) NPV_P10 PF05531.12 ETN97723.1 - 2.9 8.4 11.3 1.1e+02 3.4 11.3 2.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 ETN97723.1 - 2.9 5.3 25.8 3.5 5.0 25.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Laminin_II PF06009.12 ETN97723.1 - 3 7.9 20.0 0.8 9.7 11.8 2.1 1 1 1 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.8 ETN97723.1 - 3.1 8.0 28.4 0.18 12.1 16.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding FUSC PF04632.12 ETN97723.1 - 3.4 6.1 4.1 3.4 6.1 4.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Sec20 PF03908.13 ETN97723.1 - 4 7.4 13.3 2.6 8.0 0.5 2.8 1 1 2 3 3 3 0 Sec20 COG2 PF06148.11 ETN97723.1 - 4 7.5 17.6 0.62 10.2 8.5 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 HemX PF04375.14 ETN97723.1 - 4 6.6 30.6 1.6 8.0 20.8 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Mit_KHE1 PF10173.9 ETN97723.1 - 4.9 7.2 14.2 5.7 7.0 14.2 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related bZIP_1 PF00170.21 ETN97723.1 - 6.1 7.0 29.6 0.6 10.2 2.8 3.9 1 1 4 5 5 5 0 bZIP transcription factor Rho_Binding PF08912.11 ETN97723.1 - 6.5 7.7 33.1 35 5.3 9.7 3.5 2 1 1 3 3 3 0 Rho Binding DHR10 PF18595.1 ETN97723.1 - 6.6 6.8 33.8 1.9 8.6 24.0 2.8 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Nup88 PF10168.9 ETN97723.1 - 7.6 4.2 24.0 7.8 4.2 24.0 1.0 1 0 0 1 1 1 0 Nuclear pore component Sulfatase_C PF14707.6 ETN97723.1 - 7.9 7.2 8.2 37 5.1 8.2 2.1 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase V_ATPase_I PF01496.19 ETN97723.1 - 8 4.2 21.5 40 1.9 21.5 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-H PF05837.12 ETN97723.1 - 8.1 6.9 29.2 1.9 8.9 15.9 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF812 PF05667.11 ETN97723.1 - 8.2 5.2 31.3 50 2.6 30.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Nre_C PF04895.12 ETN97723.1 - 8.2 6.4 10.4 2.3 8.2 4.2 2.2 1 1 1 2 2 2 0 Archaeal Nre, C-terminal Prominin PF05478.11 ETN97723.1 - 8.7 4.2 14.1 9.7 4.0 14.1 1.1 1 0 0 1 1 1 0 Prominin FAA_hydro_N_2 PF18288.1 ETN97723.1 - 9.9 6.7 10.3 8.4 6.9 2.3 2.7 1 1 2 3 3 2 0 Fumarylacetoacetase N-terminal domain 2 AAA_9 PF12781.7 ETN97725.1 - 1.3e-65 220.7 0.6 2.1e-65 220.0 0.6 1.3 1 0 0 1 1 1 1 ATP-binding dynein motor region MT PF12777.7 ETN97725.1 - 2.3e-09 36.8 0.0 4.6e-09 35.8 0.0 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor WD40 PF00400.32 ETN97728.1 - 4.3e-09 36.8 3.7 0.00048 20.9 0.3 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat Mt_ATP-synt_B PF05405.14 ETN97728.1 - 0.049 13.3 0.0 0.067 12.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) CRCB PF02537.15 ETN97732.1 - 0.00012 22.3 2.2 0.00018 21.7 2.2 1.6 1 1 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) PFK PF00365.20 ETN97732.1 - 0.0045 16.4 0.0 0.0045 16.3 0.0 1.1 1 0 0 1 1 1 1 Phosphofructokinase Hid1 PF12722.7 ETN97733.1 - 0.16 10.1 22.5 0.2 9.8 22.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4778 PF16008.5 ETN97733.1 - 0.29 11.2 19.1 0.39 10.7 19.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) TFIIF_alpha PF05793.12 ETN97733.1 - 1.3 7.6 50.0 1.5 7.3 50.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4551 PF15087.6 ETN97733.1 - 6.1 5.6 23.7 7 5.4 23.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) WD40 PF00400.32 ETN97734.1 - 1.5e-15 57.3 5.1 1.6e-05 25.6 0.4 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97734.1 - 2.7e-05 24.4 0.2 0.038 14.3 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97734.1 - 0.0081 15.5 0.1 0.0081 15.5 0.1 1.6 2 0 0 2 2 2 1 WD40-like domain GET2 PF08690.10 ETN97734.1 - 0.0087 15.8 5.6 0.0099 15.6 5.6 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 Lyase_1 PF00206.20 ETN97734.1 - 0.045 13.2 4.4 0.065 12.6 4.4 1.2 1 0 0 1 1 1 0 Lyase V_ATPase_I PF01496.19 ETN97734.1 - 0.073 11.0 5.7 0.064 11.2 5.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_13 PF13166.6 ETN97734.1 - 0.085 11.5 16.9 0.1 11.2 16.9 1.1 1 0 0 1 1 1 0 AAA domain OmpH PF03938.14 ETN97734.1 - 0.26 11.6 12.5 0.46 10.8 12.5 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 ETN97734.1 - 0.45 9.9 13.4 0.67 9.4 13.4 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF2408 PF10303.9 ETN97734.1 - 0.65 10.6 11.8 1.3 9.6 11.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) PNPase PF03726.14 ETN97734.1 - 1.6 9.2 6.4 4 8.0 6.4 1.8 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain DUF4200 PF13863.6 ETN97734.1 - 2 8.8 18.7 3.8 7.9 18.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Fmp27_WPPW PF10359.9 ETN97734.1 - 5.1 5.8 16.6 10 4.8 16.6 1.5 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF1189 PF06691.11 ETN97734.1 - 5.6 6.5 9.5 7.3 6.1 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) LMBR1 PF04791.16 ETN97734.1 - 5.7 5.7 12.1 6.9 5.4 12.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RP-C_C PF11800.8 ETN97734.1 - 6 6.9 9.7 7.9 6.5 9.7 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4407 PF14362.6 ETN97734.1 - 6.4 6.0 8.7 7.9 5.7 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3342 PF11822.8 ETN97736.1 - 9.1 6.5 10.7 35 4.7 10.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) DPPIV_N PF00930.21 ETN97737.1 - 0.00023 20.1 0.0 0.00025 19.9 0.0 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region TPR_12 PF13424.6 ETN97738.1 - 5.6e-59 196.4 0.4 3.2e-21 75.4 0.0 3.7 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97738.1 - 2e-50 167.3 0.0 1.7e-10 40.4 0.0 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97738.1 - 8.8e-45 147.5 0.3 1.9e-08 33.8 0.0 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97738.1 - 5.8e-43 143.0 22.0 3.8e-09 36.0 0.7 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97738.1 - 7.9e-36 119.3 26.6 3.3e-07 30.0 0.4 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97738.1 - 7.3e-30 100.7 12.0 2.5e-06 27.1 0.2 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97738.1 - 3.8e-23 80.1 0.7 0.0032 17.7 0.0 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97738.1 - 5.8e-14 51.6 0.0 0.43 11.5 0.0 5.3 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97738.1 - 4.5e-13 49.6 0.0 0.17 12.6 0.0 5.2 3 1 2 5 5 5 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97738.1 - 8.9e-13 48.4 9.5 0.013 15.3 0.1 5.1 5 0 0 5 5 5 4 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETN97738.1 - 1.1e-11 44.6 0.9 0.0078 16.8 0.1 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97738.1 - 6e-11 41.9 24.8 0.042 13.5 0.6 7.4 5 2 2 7 7 7 5 TPR repeat PPR PF01535.20 ETN97738.1 - 2.7e-09 36.7 10.5 0.43 10.9 0.1 6.2 6 0 0 6 6 6 3 PPR repeat TPR_3 PF07720.12 ETN97738.1 - 2.9e-08 33.5 13.6 0.016 15.2 0.2 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN97738.1 - 7.1e-07 29.4 8.0 0.71 10.1 0.1 5.6 2 1 3 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 OrfA PF17495.2 ETN97738.1 - 1.3e-06 28.5 0.0 0.88 9.8 0.0 4.7 2 1 3 5 5 5 1 Vpr-like OrfA TPR_MalT PF17874.1 ETN97738.1 - 1.7e-06 27.7 0.0 0.0006 19.3 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region SNAP PF14938.6 ETN97738.1 - 2.1e-06 27.4 4.0 0.00011 21.7 1.7 2.5 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETN97738.1 - 8.4e-06 25.8 18.1 0.36 10.9 0.2 5.3 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETN97738.1 - 6.4e-05 23.4 0.2 11 6.6 0.0 3.9 3 2 1 4 4 4 0 Tetratricopeptide repeat DUF357 PF04010.13 ETN97738.1 - 0.00018 21.5 6.3 3.5 7.8 0.2 4.9 1 1 4 5 5 5 1 Protein of unknown function (DUF357) RPN7 PF10602.9 ETN97738.1 - 0.00045 20.0 8.1 0.23 11.1 2.9 4.4 1 1 1 3 3 3 1 26S proteasome subunit RPN7 DUF4810 PF16068.5 ETN97738.1 - 0.00089 19.8 4.9 2.1 9.0 0.1 4.4 3 2 1 4 4 4 1 Domain of unknown function (DUF4810) YecM PF06185.12 ETN97738.1 - 0.0092 15.7 2.7 3 7.5 0.1 4.5 2 1 3 5 5 5 1 YecM protein SHNi-TPR PF10516.9 ETN97738.1 - 0.0093 15.4 0.1 9.4 5.8 0.0 4.0 4 0 0 4 4 4 0 SHNi-TPR Sel1 PF08238.12 ETN97738.1 - 0.04 14.6 8.6 27 5.6 0.4 6.0 6 2 0 6 6 5 0 Sel1 repeat HTH_Bact PF18768.1 ETN97738.1 - 0.046 13.3 7.6 7.7 6.2 0.7 5.1 4 1 0 4 4 4 0 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETN97738.1 - 0.057 13.4 2.7 20 5.2 0.2 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF627) DUF3450 PF11932.8 ETN97738.1 - 0.075 12.3 6.4 6.5 6.0 0.1 3.9 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) SPAN-X PF07458.12 ETN97738.1 - 0.69 10.4 4.1 20 5.7 0.0 4.0 3 1 2 5 5 5 0 Sperm protein associated with nucleus, mapped to X chromosome BAR_3 PF16746.5 ETN97738.1 - 5.7 6.6 8.1 11 5.6 0.7 3.8 3 1 2 5 5 5 0 BAR domain of APPL family DUF2645 PF10840.8 ETN97740.1 - 0.037 14.7 1.4 1.2 9.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2645) DUF4249 PF14054.6 ETN97740.1 - 0.044 13.4 0.0 0.052 13.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4249) DUF3899 PF13038.6 ETN97740.1 - 1.4 9.4 4.7 1.4 9.5 0.4 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3899) O-antigen_lig PF13425.6 ETN97742.1 - 4.7 5.9 11.8 4.8 5.9 11.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein LicD PF04991.13 ETN97742.1 - 6.6 6.8 18.6 7.5 6.6 18.6 1.1 1 0 0 1 1 1 0 LicD family SID-1_RNA_chan PF13965.6 ETN97743.1 - 0.058 11.8 1.7 0.094 11.1 1.7 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 BAF1_ABF1 PF04684.13 ETN97743.1 - 0.36 9.8 28.4 0.033 13.3 22.7 1.8 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor PAT1 PF09770.9 ETN97743.1 - 0.9 7.7 25.7 1.3 7.2 25.7 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 COG2 PF06148.11 ETN97744.1 - 0.0017 18.5 3.2 0.0032 17.6 3.2 1.4 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3584 PF12128.8 ETN97744.1 - 0.0047 14.5 5.4 0.0056 14.3 5.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Occludin_ELL PF07303.13 ETN97744.1 - 0.022 15.5 8.7 0.053 14.2 8.7 1.7 1 0 0 1 1 1 0 Occludin homology domain Csm1_B PF18211.1 ETN97744.1 - 0.024 14.5 0.9 0.13 12.1 0.0 2.4 1 1 0 2 2 2 0 Csm1 subunit domain B TPR_MLP1_2 PF07926.12 ETN97744.1 - 0.052 13.6 7.0 0.042 13.9 3.7 1.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF3042 PF11240.8 ETN97744.1 - 0.13 12.3 1.1 0.37 10.9 1.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) Med4 PF10018.9 ETN97744.1 - 0.14 11.8 6.6 0.27 10.9 6.6 1.6 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 XhlA PF10779.9 ETN97744.1 - 0.5 10.6 6.6 0.13 12.5 2.0 2.5 2 1 1 3 3 3 0 Haemolysin XhlA DUF1759 PF03564.15 ETN97744.1 - 0.61 10.0 8.1 1.7 8.6 2.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) Mt_ATP-synt_D PF05873.12 ETN97744.1 - 1.4 8.8 13.4 18 5.2 10.6 2.7 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) UPF0242 PF06785.11 ETN97744.1 - 1.5 8.9 12.6 2.2 8.4 12.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RNA_pol_Rpb1_5 PF04998.17 ETN97744.1 - 2 7.8 8.9 3.1 7.2 8.9 1.3 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 TMPIT PF07851.13 ETN97744.1 - 7.9 5.6 12.0 11 5.1 11.5 1.5 1 1 0 1 1 1 0 TMPIT-like protein DnaJ PF00226.31 ETN97745.1 - 6.1e-11 42.3 0.0 1.8e-10 40.8 0.0 1.8 1 0 0 1 1 1 1 DnaJ domain Thioredoxin PF00085.20 ETN97745.1 - 9.1e-07 28.8 0.1 2.3e-06 27.5 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin CENP-B_dimeris PF09026.10 ETN97745.1 - 0.0073 16.7 4.6 0.16 12.4 0.3 2.5 2 0 0 2 2 2 2 Centromere protein B dimerisation domain OST3_OST6 PF04756.13 ETN97745.1 - 0.071 12.5 1.1 0.23 10.8 0.1 2.2 2 0 0 2 2 2 0 OST3 / OST6 family, transporter family DUF2457 PF10446.9 ETN97745.1 - 2 7.5 9.4 0.12 11.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) NARP1 PF12569.8 ETN97746.1 - 9.8e-85 285.4 14.9 2.5e-82 277.5 12.8 3.9 2 1 0 2 2 2 1 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 ETN97746.1 - 6.8e-07 28.9 5.5 0.045 13.9 0.0 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97746.1 - 1.3e-05 25.6 0.7 20 6.4 0.0 6.2 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97746.1 - 0.00021 20.9 0.9 0.18 11.5 0.0 2.9 3 0 0 3 3 3 2 TPR repeat TPR_7 PF13176.6 ETN97746.1 - 0.0011 18.9 0.1 0.18 11.9 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97746.1 - 0.006 17.1 7.6 0.098 13.2 0.6 4.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97746.1 - 0.0086 16.3 1.7 13 6.2 0.0 5.3 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97746.1 - 0.023 14.5 8.2 0.15 11.9 0.0 5.4 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97746.1 - 0.026 14.7 5.8 35 4.9 0.0 5.8 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETN97746.1 - 0.041 14.0 0.4 0.17 12.0 0.2 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ETN97747.1 - 2.9e-22 78.5 7.2 1.1e-09 38.7 0.0 4.1 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97747.1 - 1.5e-07 31.6 0.2 9.1e-05 22.7 0.1 3.2 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97747.1 - 0.00093 18.6 0.0 0.0014 18.0 0.0 1.4 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETN97747.1 - 0.0065 15.2 1.2 2.2 6.8 0.1 2.5 1 1 2 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETN97747.1 - 0.033 14.2 0.4 19 5.4 0.0 3.2 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Ge1_WD40 PF16529.5 ETN97747.1 - 0.038 12.9 0.0 0.081 11.9 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein TPR_11 PF13414.6 ETN97748.1 - 3.3e-16 58.7 4.5 2.9e-07 30.0 0.2 2.5 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 ETN97748.1 - 6.1e-15 54.3 6.1 7.3e-08 31.9 2.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97748.1 - 2.4e-13 49.1 9.1 2.7e-06 27.0 0.9 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97748.1 - 2.9e-09 37.4 0.0 6.9e-05 23.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97748.1 - 5.2e-09 36.2 0.0 0.00061 20.4 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97748.1 - 2.4e-06 27.3 3.5 0.0026 17.9 1.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat RPN7 PF10602.9 ETN97748.1 - 7.7e-05 22.5 9.9 0.00094 18.9 4.5 2.4 1 1 1 2 2 2 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETN97748.1 - 0.0001 22.8 0.1 0.24 11.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97748.1 - 0.00015 21.6 0.1 0.049 13.7 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97748.1 - 0.00017 22.0 2.1 0.089 13.5 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETN97748.1 - 0.00049 20.3 4.7 0.48 10.7 1.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat SLC12 PF03522.15 ETN97748.1 - 0.0022 17.1 10.0 0.0037 16.4 10.0 1.3 1 0 0 1 1 1 1 Solute carrier family 12 TPR_17 PF13431.6 ETN97748.1 - 0.0083 16.4 2.6 2 9.0 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPM_phosphatase PF04536.14 ETN97748.1 - 0.017 15.3 0.0 0.043 14.0 0.0 1.8 1 0 0 1 1 1 0 TPM domain TPR_21 PF09976.9 ETN97748.1 - 0.038 13.7 11.6 1.1 8.9 0.1 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain NPR3 PF03666.13 ETN97748.1 - 0.06 12.1 13.2 0.089 11.6 13.2 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETN97748.1 - 0.084 11.6 12.0 0.12 11.1 12.0 1.3 1 0 0 1 1 1 0 Presenilin TPR_10 PF13374.6 ETN97748.1 - 0.11 12.5 9.8 0.56 10.1 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat CAML PF14963.6 ETN97748.1 - 0.31 11.1 12.8 0.48 10.5 12.8 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand MAJIN PF15077.6 ETN97748.1 - 0.54 10.0 11.9 0.99 9.1 11.9 1.4 1 0 0 1 1 1 0 Membrane-anchored junction protein FAT PF02259.23 ETN97748.1 - 0.81 8.8 13.5 0.2 10.8 0.3 2.2 2 0 0 2 2 2 0 FAT domain Hid1 PF12722.7 ETN97748.1 - 4.7 5.2 14.1 6 4.9 14.1 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Dsh_C PF12316.8 ETN97748.1 - 6.7 7.1 6.6 10 6.4 6.6 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Gti1_Pac2 PF09729.9 ETN97748.1 - 7.3 6.6 14.2 0.88 9.6 9.9 1.7 2 0 0 2 2 2 0 Gti1/Pac2 family HSP70 PF00012.20 ETN97749.1 - 3.1e-47 161.1 0.0 1.1e-46 159.3 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETN97749.1 - 2.4e-05 23.3 0.0 9.1e-05 21.4 0.0 2.0 2 1 1 3 3 3 1 MreB/Mbl protein DUF2709 PF10915.8 ETN97754.1 - 0.0032 16.8 0.0 0.0039 16.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2709) PPR_3 PF13812.6 ETN97755.1 - 0.021 14.9 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain TMEM215 PF15746.5 ETN97755.1 - 0.052 13.0 0.2 0.063 12.7 0.2 1.1 1 0 0 1 1 1 0 TMEM215 family OAD_gamma PF04277.13 ETN97756.1 - 0.093 13.3 0.0 0.12 13.0 0.0 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain CCSAP PF15748.5 ETN97757.1 - 0.0019 18.4 23.0 0.002 18.4 23.0 1.1 1 0 0 1 1 1 1 Centriole, cilia and spindle-associated NPR3 PF03666.13 ETN97757.1 - 0.0028 16.5 28.1 0.0037 16.1 28.1 1.0 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETN97757.1 - 0.0094 15.2 11.3 0.0095 15.2 11.3 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter GAGA_bind PF06217.12 ETN97757.1 - 0.011 16.1 20.3 0.014 15.7 20.3 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family SAPS PF04499.15 ETN97757.1 - 0.018 13.9 14.5 0.018 13.9 14.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LicD PF04991.13 ETN97757.1 - 0.04 14.0 14.3 0.047 13.8 14.3 1.2 1 0 0 1 1 1 0 LicD family RRN3 PF05327.11 ETN97757.1 - 0.055 12.0 13.8 0.067 11.7 13.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 ETN97757.1 - 0.058 13.2 33.6 0.075 12.9 33.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 ETN97757.1 - 0.078 12.1 19.7 0.099 11.7 19.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Caldesmon PF02029.15 ETN97757.1 - 0.078 11.7 36.3 0.094 11.5 36.3 1.0 1 0 0 1 1 1 0 Caldesmon SRP-alpha_N PF04086.13 ETN97757.1 - 0.18 11.7 29.2 0.22 11.4 29.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Smg8_Smg9 PF10220.9 ETN97757.1 - 0.22 9.8 18.5 0.24 9.6 18.5 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Endostatin PF06482.11 ETN97757.1 - 0.23 10.9 13.6 0.3 10.5 13.6 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Dapper PF15268.6 ETN97757.1 - 0.27 10.1 23.3 0.31 9.8 23.3 1.0 1 0 0 1 1 1 0 Dapper PA26 PF04636.13 ETN97757.1 - 0.29 10.0 16.8 0.32 9.9 16.8 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Ydc2-catalyt PF09159.10 ETN97757.1 - 0.31 10.7 21.9 0.4 10.4 21.9 1.1 1 0 0 1 1 1 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 Vfa1 PF08432.10 ETN97757.1 - 0.37 11.1 41.3 0.6 10.4 41.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CLN3 PF02487.17 ETN97757.1 - 0.45 9.5 14.3 0.69 8.9 14.3 1.3 1 0 0 1 1 1 0 CLN3 protein DUF2201_N PF13203.6 ETN97757.1 - 0.46 10.0 10.4 0.64 9.6 10.4 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Nucleo_P87 PF07267.11 ETN97757.1 - 0.49 9.2 20.5 0.59 8.9 20.5 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF2052 PF09747.9 ETN97757.1 - 0.54 10.4 28.0 0.8 9.8 28.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Cellulose_synt PF03552.14 ETN97757.1 - 0.65 8.4 10.5 0.79 8.1 10.5 1.1 1 0 0 1 1 1 0 Cellulose synthase Presenilin PF01080.17 ETN97757.1 - 0.67 8.7 29.0 0.83 8.3 29.0 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETN97757.1 - 0.78 9.8 14.7 0.95 9.5 14.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Asp-B-Hydro_N PF05279.11 ETN97757.1 - 0.85 9.6 28.7 1.1 9.3 28.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region XRN_M PF17846.1 ETN97757.1 - 1.3 7.9 21.2 1.5 7.7 21.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain SID-1_RNA_chan PF13965.6 ETN97757.1 - 1.4 7.2 10.6 1.6 7.0 10.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GREB1 PF15782.5 ETN97757.1 - 1.4 5.9 16.6 1.6 5.8 16.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOBP PF15279.6 ETN97757.1 - 1.5 9.4 16.4 1.8 9.1 16.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein SLC12 PF03522.15 ETN97757.1 - 1.6 7.7 29.3 1.9 7.4 29.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Mitofilin PF09731.9 ETN97757.1 - 1.6 7.5 32.8 1.9 7.2 32.8 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Dsh_C PF12316.8 ETN97757.1 - 2.4 8.5 11.3 3.3 8.1 11.3 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal ALMT PF11744.8 ETN97757.1 - 2.7 6.7 20.9 3.3 6.4 20.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 ETN97757.1 - 3.1 6.0 32.6 4 5.6 32.6 1.1 1 0 0 1 1 1 0 CDC45-like protein SprA-related PF12118.8 ETN97757.1 - 3.9 6.5 27.3 4.8 6.2 27.3 1.2 1 0 0 1 1 1 0 SprA-related family AF-4 PF05110.13 ETN97757.1 - 4 5.4 34.6 5.3 5.0 34.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MMR1 PF08505.10 ETN97757.1 - 4.6 7.5 28.1 5.7 7.2 28.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SelP_N PF04592.14 ETN97757.1 - 4.7 6.5 20.5 6 6.2 20.5 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region HSP70 PF00012.20 ETN97757.1 - 5 5.2 22.8 5.6 5.0 22.8 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF3807 PF12720.7 ETN97757.1 - 5.1 7.3 39.0 8.1 6.7 39.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Tyrosinase PF00264.20 ETN97757.1 - 6.3 7.0 8.9 8.2 6.6 8.9 1.1 1 0 0 1 1 1 0 Common central domain of tyrosinase Sec62 PF03839.16 ETN97757.1 - 6.9 6.1 33.2 11 5.5 33.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 PBP_sp32 PF07222.12 ETN97757.1 - 7.2 6.0 25.4 12 5.2 25.4 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 HCO3_cotransp PF00955.21 ETN97757.1 - 7.7 5.2 8.9 9.3 4.9 8.9 1.2 1 0 0 1 1 1 0 HCO3- transporter family LMBR1 PF04791.16 ETN97757.1 - 9.5 5.0 11.1 10 4.9 11.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_11 PF13086.6 ETN97757.1 - 9.6 5.9 28.6 13 5.4 28.6 1.2 1 0 0 1 1 1 0 AAA domain A_deaminase PF00962.22 ETN97758.1 - 7.7e-06 25.5 0.0 9.8e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Pox_A3L PF05288.11 ETN97760.1 - 0.13 12.3 2.0 5 7.2 0.3 2.1 1 1 1 2 2 2 0 Poxvirus A3L Protein DWNN PF08783.11 ETN97760.1 - 0.16 12.3 3.6 0.87 9.9 0.4 2.1 1 1 0 2 2 2 0 DWNN domain Sulfotransfer_3 PF13469.6 ETN97761.1 - 0.00013 22.5 0.0 0.00062 20.2 0.0 1.9 2 0 0 2 2 2 1 Sulfotransferase family Equine_IAV_S2 PF06502.11 ETN97761.1 - 0.09 12.9 1.4 0.22 11.6 1.4 1.7 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein Pox_G5 PF04599.12 ETN97761.1 - 0.57 9.1 6.0 0.82 8.6 6.0 1.2 1 0 0 1 1 1 0 Poxvirus G5 protein Inhibitor_I71 PF12628.7 ETN97761.1 - 0.86 9.4 11.2 1.7 8.5 11.2 1.5 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Agouti PF05039.12 ETN97761.1 - 1.4 9.6 5.4 0.9 10.3 0.7 2.6 3 0 0 3 3 3 0 Agouti protein DUF2457 PF10446.9 ETN97762.1 - 0.017 14.3 25.1 0.02 14.1 25.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sin_N PF04801.13 ETN97762.1 - 0.6 9.3 15.5 0.79 8.9 15.5 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region DUF999 PF06198.11 ETN97762.1 - 0.69 9.9 7.6 1.1 9.2 7.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF999) Sporozoite_P67 PF05642.11 ETN97762.1 - 0.72 7.9 14.8 0.92 7.5 14.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3347 PF11827.8 ETN97762.1 - 1.2 9.2 21.8 1.7 8.8 21.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) BUD22 PF09073.10 ETN97762.1 - 1.3 8.3 31.1 1.5 8.1 31.1 1.0 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETN97762.1 - 2.5 6.3 25.4 3 6.0 25.4 1.1 1 0 0 1 1 1 0 CDC45-like protein PI3K_1B_p101 PF10486.9 ETN97762.1 - 4 5.1 21.2 4.7 4.9 21.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LAP1C PF05609.12 ETN97762.1 - 7.7 5.5 24.9 8.8 5.3 24.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WD40 PF00400.32 ETN97763.1 - 9.4e-06 26.3 1.1 0.00026 21.7 0.2 2.7 2 1 0 2 2 2 1 WD domain, G-beta repeat HmuY PF14064.6 ETN97763.1 - 0.053 13.7 0.1 0.059 13.6 0.1 1.1 1 0 0 1 1 1 0 HmuY protein Nup160 PF11715.8 ETN97763.1 - 0.083 11.5 0.0 0.083 11.5 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 RNase_H PF00075.24 ETN97764.1 - 3.5e-11 43.5 0.0 4.8e-11 43.0 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETN97764.1 - 8.3e-05 22.4 0.0 0.00013 21.7 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase-like AfsA PF03756.13 ETN97764.1 - 0.015 15.3 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 A-factor biosynthesis hotdog domain RPAP1_N PF08621.10 ETN97764.1 - 0.023 14.4 0.3 0.058 13.2 0.0 1.7 2 0 0 2 2 2 0 RPAP1-like, N-terminal WD40 PF00400.32 ETN97765.1 - 1.8e-10 41.2 2.8 6.5e-06 26.8 0.2 2.8 3 1 0 3 3 3 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETN97765.1 - 0.033 14.2 0.4 0.11 12.5 0.3 2.1 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ETN97765.1 - 0.1 11.2 0.1 0.82 8.2 0.0 1.8 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PPR_3 PF13812.6 ETN97767.1 - 0.0072 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Pentatricopeptide repeat domain DUF1652 PF07865.11 ETN97767.1 - 0.12 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1652) NACHT PF05729.12 ETN97768.1 - 5.6e-08 32.9 0.0 9.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETN97768.1 - 5.4e-06 27.0 0.2 3e-05 24.6 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETN97768.1 - 0.00013 22.3 0.1 0.00041 20.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 ETN97768.1 - 0.00032 20.7 0.0 0.00099 19.1 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETN97768.1 - 0.0037 17.6 0.2 0.011 16.1 0.2 2.0 1 1 0 1 1 1 1 RNA helicase ABC_tran PF00005.27 ETN97768.1 - 0.0038 17.7 0.1 0.0056 17.2 0.1 1.3 1 1 0 1 1 1 1 ABC transporter AAA_17 PF13207.6 ETN97768.1 - 0.0038 17.6 0.0 0.0092 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETN97768.1 - 0.0052 16.7 0.1 0.011 15.6 0.1 1.7 1 1 1 2 2 2 1 RsgA GTPase ATP_bind_2 PF03668.15 ETN97768.1 - 0.0079 15.5 0.0 0.01 15.2 0.0 1.2 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_33 PF13671.6 ETN97768.1 - 0.019 15.1 0.0 0.031 14.4 0.0 1.5 1 1 0 1 1 1 0 AAA domain Torsin PF06309.11 ETN97768.1 - 0.022 14.9 0.0 0.033 14.3 0.0 1.3 1 0 0 1 1 1 0 Torsin AAA_30 PF13604.6 ETN97768.1 - 0.022 14.5 0.0 0.027 14.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Cytidylate_kin PF02224.18 ETN97768.1 - 0.03 14.0 0.0 0.043 13.6 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase Sigma54_activat PF00158.26 ETN97768.1 - 0.031 14.0 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 ETN97768.1 - 0.045 13.0 0.0 0.058 12.7 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 ETN97768.1 - 0.048 14.0 0.1 0.11 12.8 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 ETN97768.1 - 0.05 13.3 0.2 0.14 11.9 0.0 2.0 1 1 1 2 2 2 0 AAA domain PRK PF00485.18 ETN97768.1 - 0.053 13.3 0.0 0.094 12.4 0.0 1.4 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATPase PF06745.13 ETN97768.1 - 0.057 12.8 0.4 0.45 9.8 0.0 2.1 1 1 1 2 2 2 0 KaiC AAA_5 PF07728.14 ETN97768.1 - 0.064 13.3 0.0 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) KAP_NTPase PF07693.14 ETN97768.1 - 0.066 12.4 0.0 0.11 11.7 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain AAA_21 PF13304.6 ETN97768.1 - 0.074 12.8 0.2 0.11 12.2 0.2 1.3 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PduV-EutP PF10662.9 ETN97768.1 - 0.09 12.5 0.0 0.19 11.5 0.0 1.5 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CPT PF07931.12 ETN97768.1 - 0.14 12.0 0.0 0.15 11.9 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein CbiA PF01656.23 ETN97768.1 - 0.22 11.6 0.2 2 8.5 0.2 2.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain ILEI PF15711.5 ETN97769.1 - 0.032 14.7 0.1 0.098 13.1 0.1 1.9 2 0 0 2 2 2 0 Interleukin-like EMT inducer RNA_pol_Rpb5_C PF01191.19 ETN97769.1 - 0.25 11.2 2.2 1.7 8.6 0.3 2.4 2 1 1 3 3 3 0 RNA polymerase Rpb5, C-terminal domain Rad51 PF08423.11 ETN97771.1 - 9.8e-06 25.0 0.0 2.4e-05 23.7 0.0 1.6 1 0 0 1 1 1 1 Rad51 AAA_29 PF13555.6 ETN97771.1 - 0.0017 18.1 0.0 0.0037 17.0 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ETN97771.1 - 0.0018 18.8 0.8 0.0057 17.2 0.5 1.9 1 1 0 1 1 1 1 ABC transporter NARP1 PF12569.8 ETN97772.1 - 2.7e-27 95.9 8.2 2e-26 93.0 8.0 2.2 1 1 2 3 3 3 2 NMDA receptor-regulated protein 1 DUF4709 PF15821.5 ETN97772.1 - 0.074 13.3 1.3 0.25 11.6 0.1 2.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4709) ER PF01133.17 ETN97772.1 - 0.12 12.4 1.8 0.23 11.5 0.5 2.1 2 0 0 2 2 2 0 Enhancer of rudimentary TSNAXIP1_N PF15739.5 ETN97772.1 - 0.7 10.3 4.7 0.14 12.6 0.5 1.9 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Peptidase_A3 PF02160.15 ETN97773.1 - 0.0094 15.5 5.0 0.014 14.9 5.0 1.3 1 0 0 1 1 1 1 Cauliflower mosaic virus peptidase (A3) RelE PF06296.12 ETN97774.1 - 0.074 13.2 0.1 0.097 12.8 0.1 1.2 1 0 0 1 1 1 0 RelE toxin of RelE / RelB toxin-antitoxin system DUF4549 PF15082.6 ETN97774.1 - 0.23 11.3 3.0 1.9 8.2 1.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4549) SAM_1 PF00536.30 ETN97779.1 - 0.0069 16.8 0.0 0.014 15.8 0.0 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) Kelch_4 PF13418.6 ETN97783.1 - 2.4e-06 27.4 0.1 0.00062 19.7 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN97783.1 - 2.4e-06 27.3 0.2 0.0074 16.2 0.2 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETN97783.1 - 1.4e-05 24.5 0.5 2.8e-05 23.6 0.5 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 ETN97783.1 - 2.1e-05 24.6 0.2 0.059 13.7 0.1 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETN97783.1 - 0.0013 18.7 0.9 0.0047 16.9 0.9 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETN97783.1 - 0.0017 18.6 0.2 0.0052 17.0 0.1 1.9 2 0 0 2 2 2 1 Galactose oxidase, central domain UCH PF00443.29 ETN97788.1 - 0.00037 20.1 0.8 0.0025 17.3 0.8 2.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETN97789.1 - 1e-16 61.2 8.1 4.9e-15 55.7 8.1 2.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PNPase PF03726.14 ETN97789.1 - 0.19 12.3 1.5 1.3 9.6 0.2 3.0 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain FAM176 PF14851.6 ETN97789.1 - 0.46 10.1 4.7 0.37 10.5 1.2 2.3 2 0 0 2 2 2 0 FAM176 family WD40 PF00400.32 ETN97790.1 - 2e-22 79.1 18.0 1.4e-07 32.1 2.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97790.1 - 1.1e-06 28.9 0.2 0.076 13.3 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97790.1 - 0.031 12.9 4.3 8.3 4.9 1.0 3.6 3 1 0 3 3 3 0 Nucleoporin Nup120/160 FTHFS PF01268.19 ETN97792.1 - 0.058 11.6 1.4 0.062 11.5 1.4 1.2 1 0 0 1 1 1 0 Formate--tetrahydrofolate ligase 7TMR-HDED PF07697.11 ETN97792.1 - 0.062 13.4 4.8 0.083 13.0 4.8 1.2 1 0 0 1 1 1 0 7TM-HD extracellular Exonuc_VII_L PF02601.15 ETN97792.1 - 0.16 11.5 4.5 0.18 11.3 4.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OSCP PF00213.18 ETN97792.1 - 0.22 11.6 5.7 0.71 10.0 5.7 1.8 1 1 0 1 1 1 0 ATP synthase delta (OSCP) subunit DUF948 PF06103.11 ETN97792.1 - 0.5 10.7 4.7 0.87 9.9 1.8 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 ETN97792.1 - 0.52 9.1 6.5 0.63 8.9 6.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 ETN97792.1 - 1.2 9.5 14.2 3.6 7.9 14.2 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 ETN97792.1 - 1.3 8.2 7.1 1.7 7.8 7.1 1.4 1 0 0 1 1 1 0 TMPIT-like protein Atg14 PF10186.9 ETN97792.1 - 2.1 7.4 11.8 3.2 6.8 11.8 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 mCpol PF18182.1 ETN97792.1 - 2.3 8.6 7.7 6.2 7.2 0.6 2.7 1 1 1 3 3 3 0 minimal CRISPR polymerase domain Glyco_H_20C_C PF18088.1 ETN97794.1 - 0.012 15.5 5.6 0.017 15.0 5.6 1.2 1 0 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain APG6_N PF17675.1 ETN97794.1 - 0.17 12.4 17.0 0.33 11.5 17.0 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region ApoO PF09769.9 ETN97794.1 - 0.2 11.7 3.7 0.26 11.3 2.0 1.8 1 1 1 2 2 2 0 Apolipoprotein O DUF2400 PF09674.10 ETN97794.1 - 0.48 10.4 10.9 0.14 12.1 8.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) BT1 PF03092.16 ETN97794.1 - 0.82 7.8 4.2 1.5 7.0 4.2 1.3 1 0 0 1 1 1 0 BT1 family AAA_11 PF13086.6 ETN97794.1 - 1.1 9.0 10.9 1.6 8.4 10.9 1.2 1 0 0 1 1 1 0 AAA domain DUF719 PF05334.13 ETN97794.1 - 2.3 8.4 11.7 6.1 7.0 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF719) G_path_suppress PF15991.5 ETN97794.1 - 8.9 6.4 22.5 12 5.9 22.5 1.2 1 0 0 1 1 1 0 G-protein pathway suppressor DUF1664 PF07889.12 ETN97794.1 - 9.3 6.3 9.5 8.1 6.5 6.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Iron_permease PF04120.12 ETN97796.1 - 0.033 14.0 0.1 0.062 13.1 0.1 1.5 1 1 1 2 2 2 0 Low affinity iron permease Peptidase_M1 PF01433.20 ETN97799.1 - 5.9e-27 94.6 0.0 9.6e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ETN97799.1 - 4.7e-22 78.9 0.4 1.2e-20 74.3 0.4 2.2 1 1 0 1 1 1 1 ERAP1-like C-terminal domain YccJ PF13993.6 ETN97799.1 - 0.11 12.8 0.1 0.32 11.4 0.1 1.8 1 0 0 1 1 1 0 YccJ-like protein TPR_12 PF13424.6 ETN97801.1 - 3.7e-72 238.6 20.0 1.6e-20 73.2 0.4 3.9 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97801.1 - 1.9e-41 138.8 1.8 6.4e-09 35.4 0.1 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97801.1 - 1.1e-30 104.1 30.5 8.7e-09 34.8 0.8 6.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97801.1 - 1.5e-30 102.9 6.0 1.2e-06 28.1 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97801.1 - 2.4e-26 89.7 18.8 8e-07 28.7 0.2 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97801.1 - 2.8e-22 77.0 28.8 1.8e-08 33.9 0.9 5.4 6 0 0 6 6 4 4 Tetratricopeptide repeat TPR_3 PF07720.12 ETN97801.1 - 2.8e-11 43.2 19.6 0.0017 18.3 0.6 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97801.1 - 3.4e-11 43.0 2.4 0.32 11.7 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97801.1 - 1e-10 42.1 0.1 0.27 11.9 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97801.1 - 1.9e-10 40.4 9.7 0.4 11.2 0.0 6.4 6 2 0 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97801.1 - 1.2e-09 38.1 0.0 1.1 10.3 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97801.1 - 2.3e-07 30.4 31.7 0.00044 19.9 0.9 6.0 5 2 2 7 7 7 4 TPR repeat DUF5113 PF17140.4 ETN97801.1 - 6.5e-05 22.8 13.2 0.2 11.5 0.1 4.4 3 1 1 4 4 4 2 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETN97801.1 - 8.9e-05 22.0 0.0 0.01 15.2 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region SNAP PF14938.6 ETN97801.1 - 0.00065 19.2 5.4 0.012 15.0 1.1 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETN97801.1 - 0.0012 19.0 10.8 0.94 9.9 0.1 5.7 6 0 0 6 6 6 1 PPR repeat TPR_9 PF13371.6 ETN97801.1 - 0.0055 16.8 0.0 0.38 10.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN97801.1 - 0.0059 16.6 20.9 0.16 12.0 0.9 4.6 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ETN97801.1 - 0.0075 16.5 20.3 0.054 13.7 0.9 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETN97801.1 - 0.015 14.8 0.3 20 4.8 0.0 3.8 4 0 0 4 4 4 0 SHNi-TPR Sel1 PF08238.12 ETN97801.1 - 0.042 14.5 15.5 2.2 9.1 0.2 5.2 5 2 0 5 5 4 0 Sel1 repeat SPO22 PF08631.10 ETN97801.1 - 0.051 13.0 10.7 0.91 9.0 0.7 4.2 3 2 1 5 5 5 0 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETN97801.1 - 0.059 13.4 17.4 1.3 9.1 0.5 4.5 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain ATP-synt_E_2 PF08112.11 ETN97801.1 - 0.08 13.2 5.3 17 5.8 0.1 4.1 3 0 0 3 3 3 0 ATP synthase epsilon subunit DUF4810 PF16068.5 ETN97801.1 - 0.36 11.4 8.5 4.4 7.9 0.7 3.7 3 1 1 4 4 3 0 Domain of unknown function (DUF4810) Mob_Pre PF01076.19 ETN97801.1 - 0.63 9.8 9.8 0.047 13.5 1.4 3.0 2 1 1 3 3 3 0 Plasmid recombination enzyme RSS_P20 PF11757.8 ETN97801.1 - 3.5 8.2 10.6 3.1 8.3 0.3 4.2 5 1 1 6 6 4 0 Suppressor of RNA silencing P21-like N-terminal domain RPN7 PF10602.9 ETN97801.1 - 5.3 6.7 14.5 5.6 6.6 0.8 4.2 2 1 2 5 5 5 0 26S proteasome subunit RPN7 TPR_12 PF13424.6 ETN97802.1 - 2.4e-44 149.5 7.1 8.8e-20 70.8 0.1 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97802.1 - 5.5e-32 108.7 0.1 1.1e-09 37.8 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97802.1 - 3.6e-26 89.9 20.1 5.5e-10 38.6 2.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97802.1 - 1.5e-25 87.3 1.6 5.4e-08 32.3 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97802.1 - 8e-21 72.5 17.6 8.5e-09 34.9 2.2 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97802.1 - 1.8e-20 71.3 12.6 1.2e-07 31.2 0.7 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97802.1 - 2.3e-10 40.1 10.0 7.9e-05 22.8 0.0 4.8 5 1 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97802.1 - 1.8e-09 38.1 0.0 0.0089 16.7 0.1 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97802.1 - 5.5e-09 36.1 1.3 0.003 18.1 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97802.1 - 8.5e-07 29.3 0.0 0.15 13.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat PPR PF01535.20 ETN97802.1 - 9.7e-07 28.6 6.8 0.085 13.1 0.1 4.9 5 0 0 5 5 5 2 PPR repeat TPR_11 PF13414.6 ETN97802.1 - 2.8e-06 26.9 21.1 0.046 13.4 2.9 5.7 4 2 2 6 6 6 4 TPR repeat DUF5113 PF17140.4 ETN97802.1 - 3.6e-06 26.9 3.9 0.064 13.1 0.1 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETN97802.1 - 6.7e-06 26.0 11.6 0.02 14.9 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat SNAP PF14938.6 ETN97802.1 - 1e-05 25.1 7.7 0.00067 19.2 2.3 2.0 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP ATP-synt_E_2 PF08112.11 ETN97802.1 - 0.00026 21.2 6.2 0.41 10.9 0.1 3.8 3 0 0 3 3 3 2 ATP synthase epsilon subunit TPR_MalT PF17874.1 ETN97802.1 - 0.0009 18.7 0.0 0.0013 18.1 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region TPR_19 PF14559.6 ETN97802.1 - 0.0063 17.0 0.1 0.38 11.3 0.1 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 ETN97802.1 - 0.013 15.2 9.5 1.4 8.6 0.1 3.9 1 1 3 4 4 4 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 ETN97802.1 - 0.029 14.6 12.3 0.55 10.5 0.5 4.1 2 2 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ETN97802.1 - 0.035 14.2 6.7 0.072 13.2 0.9 2.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 ETN97802.1 - 0.2 11.7 11.8 2.2 8.4 1.0 3.8 5 0 0 5 5 3 0 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 ETN97802.1 - 0.25 10.8 4.8 4.3 6.7 0.3 3.1 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like HTH_Bact PF18768.1 ETN97802.1 - 0.54 9.9 5.9 13 5.4 2.1 4.0 2 2 1 3 3 3 0 Helix-turn-helix bacterial domain Prefoldin PF02996.17 ETN97802.1 - 0.87 9.5 4.8 3.1 7.7 0.1 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF4810 PF16068.5 ETN97802.1 - 0.9 10.1 6.2 1.1 9.8 0.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) Sel1 PF08238.12 ETN97802.1 - 0.94 10.3 10.0 14 6.6 0.7 4.8 4 3 0 4 4 3 0 Sel1 repeat TMEM215 PF15746.5 ETN97803.1 - 0.051 13.0 0.1 0.058 12.8 0.1 1.1 1 0 0 1 1 1 0 TMEM215 family TLD PF07534.16 ETN97804.1 - 0.056 13.7 0.9 0.29 11.3 0.2 2.0 1 1 1 2 2 2 0 TLD DUF4853 PF16145.5 ETN97804.1 - 0.11 12.7 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) PUB PF09409.10 ETN97804.1 - 0.11 12.4 5.0 0.14 12.1 1.3 2.6 2 1 0 2 2 2 0 PUB domain CW_binding_1 PF01473.20 ETN97804.1 - 0.11 12.8 5.0 0.27 11.6 5.0 1.7 1 0 0 1 1 1 0 Putative cell wall binding repeat Dynamin_N PF00350.23 ETN97805.1 - 0.0016 18.5 0.2 0.0016 18.5 0.2 3.0 2 1 2 4 4 4 1 Dynamin family MMR_HSR1 PF01926.23 ETN97805.1 - 0.11 12.6 2.0 0.39 10.8 1.6 2.4 1 1 0 1 1 1 0 50S ribosome-binding GTPase Connexin PF00029.19 ETN97806.1 - 0.066 13.0 1.7 0.095 12.4 1.7 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETN97806.1 - 2.4 6.8 5.7 2.6 6.7 5.7 1.1 1 0 0 1 1 1 0 Presenilin SH3_4 PF06347.13 ETN97809.1 - 0.079 12.8 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain RVT_1 PF00078.27 ETN97810.1 - 0.00019 21.0 0.8 0.00028 20.5 0.8 1.5 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Herpes_TK_C PF08465.10 ETN97810.1 - 0.092 12.5 0.2 0.23 11.2 0.2 1.7 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal Tmemb_14 PF03647.13 ETN97810.1 - 0.2 12.4 0.1 0.24 12.2 0.1 1.3 1 1 0 1 1 1 0 Transmembrane proteins 14C SwrA PF17423.2 ETN97812.1 - 0.17 11.9 1.3 1.5 8.8 1.1 2.1 1 1 0 1 1 1 0 Swarming motility protein FAD_binding_4 PF01565.23 ETN97813.1 - 0.0025 17.6 0.0 0.046 13.5 0.0 2.1 2 0 0 2 2 2 2 FAD binding domain Copine PF07002.16 ETN97814.1 - 1.9e-38 132.1 0.4 2.6e-38 131.7 0.4 1.2 1 0 0 1 1 1 1 Copine Adaptin_binding PF10199.9 ETN97815.1 - 0.044 14.4 0.4 0.073 13.7 0.4 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 TB2_DP1_HVA22 PF03134.19 ETN97815.1 - 0.12 12.4 0.1 0.29 11.1 0.1 1.6 2 0 0 2 2 2 0 TB2/DP1, HVA22 family Gly_kinase PF02595.15 ETN97815.1 - 0.22 10.5 0.1 0.32 10.0 0.1 1.2 1 0 0 1 1 1 0 Glycerate kinase family DUF4604 PF15377.6 ETN97817.1 - 0.17 12.3 6.5 0.21 12.0 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Glyco_hydro_2_C PF02836.17 ETN97818.1 - 1.4e-07 30.9 1.0 3.5e-06 26.4 1.0 2.2 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain CTP_transf_3 PF02348.19 ETN97819.1 - 0.094 12.6 0.1 0.1 12.5 0.1 1.1 1 0 0 1 1 1 0 Cytidylyltransferase OGG_N PF07934.12 ETN97820.1 - 0.81 9.8 6.9 7.6 6.7 0.5 2.8 1 1 1 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain Peptidase_S8_N PF16361.5 ETN97821.1 - 0.089 13.3 0.0 0.13 12.7 0.0 1.3 1 0 0 1 1 1 0 N-terminal of Subtilase family Gln-synt_C PF00120.24 ETN97822.1 - 2.5e-27 95.8 0.0 2.7e-27 95.7 0.0 1.0 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain HEAT_2 PF13646.6 ETN97823.1 - 0.0032 17.8 0.0 0.0055 17.1 0.0 1.4 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.22 ETN97823.1 - 0.0033 17.5 0.0 1.6 9.2 0.0 2.6 2 1 0 2 2 2 2 HEAT repeat Vac14_Fab1_bd PF12755.7 ETN97823.1 - 0.0054 17.3 0.1 0.024 15.2 0.0 1.8 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region NLE PF08154.12 ETN97823.1 - 0.006 17.1 0.2 0.052 14.1 0.0 2.0 1 1 1 2 2 2 1 NLE (NUC135) domain bVLRF1 PF18826.1 ETN97823.1 - 0.028 14.3 0.0 0.031 14.1 0.0 1.1 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor p25-alpha PF05517.12 ETN97823.1 - 0.06 13.5 0.0 0.12 12.6 0.0 1.5 1 1 0 1 1 1 0 p25-alpha Baculo_PEP_C PF04513.12 ETN97824.1 - 0.012 15.6 6.5 0.019 15.0 6.5 1.3 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Serine_rich PF08824.10 ETN97824.1 - 0.018 15.0 2.2 0.021 14.8 2.2 1.1 1 0 0 1 1 1 0 Serine rich protein interaction domain RSS_P20 PF11757.8 ETN97824.1 - 0.021 15.2 5.5 0.076 13.5 2.2 2.1 1 1 1 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain DUF2175 PF09943.9 ETN97824.1 - 0.028 14.7 0.7 0.038 14.3 0.7 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) EMP24_GP25L PF01105.24 ETN97824.1 - 0.035 14.0 3.3 0.044 13.7 3.2 1.3 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF724 PF05266.14 ETN97824.1 - 0.055 13.3 4.4 0.059 13.2 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) NPV_P10 PF05531.12 ETN97824.1 - 0.072 13.6 8.5 1.8 9.1 8.5 2.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein E2F_CC-MB PF16421.5 ETN97824.1 - 0.097 13.0 3.3 0.15 12.4 2.5 1.7 2 0 0 2 2 2 0 E2F transcription factor CC-MB domain FlaC_arch PF05377.11 ETN97824.1 - 0.16 12.4 8.2 4.7 7.7 5.2 3.2 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ETN97824.1 - 0.16 12.0 6.4 0.26 11.3 6.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) BLOC1_2 PF10046.9 ETN97824.1 - 0.96 9.8 9.6 1.6 9.0 4.1 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 XhlA PF10779.9 ETN97824.1 - 0.96 9.7 9.1 4.7 7.5 0.4 2.2 1 1 1 2 2 2 0 Haemolysin XhlA DivIC PF04977.15 ETN97824.1 - 9.1 6.1 9.9 3.1 7.6 5.8 2.0 1 1 1 2 2 2 0 Septum formation initiator WD40 PF00400.32 ETN97826.1 - 1.8e-11 44.4 3.2 0.0034 18.2 0.0 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97826.1 - 0.041 14.2 0.1 3.4 8.0 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain G_glu_transpept PF01019.21 ETN97827.1 - 1.8e-56 192.0 0.0 2.2e-56 191.7 0.0 1.1 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Glycolytic PF00274.19 ETN97827.1 - 0.19 10.4 0.1 0.7 8.6 0.0 1.8 2 0 0 2 2 2 0 Fructose-bisphosphate aldolase class-I ANAPC4 PF12896.7 ETN97828.1 - 0.01 15.4 1.8 0.023 14.2 1.1 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 Spc7 PF08317.11 ETN97828.1 - 0.011 14.6 5.7 0.018 14.0 5.7 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein LMBR1 PF04791.16 ETN97828.1 - 0.015 14.2 0.9 0.015 14.2 0.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein PhaP_Bmeg PF09602.10 ETN97828.1 - 0.023 14.6 7.9 0.068 13.1 4.3 2.2 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Cluap1 PF10234.9 ETN97828.1 - 0.048 13.0 3.4 0.089 12.2 3.4 1.5 1 0 0 1 1 1 0 Clusterin-associated protein-1 Fibroin_P25 PF07294.11 ETN97828.1 - 0.084 12.9 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Fibroin P25 Sec66 PF09802.9 ETN97828.1 - 0.15 11.6 2.7 0.2 11.2 0.4 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit Sec66 DUF948 PF06103.11 ETN97828.1 - 0.16 12.2 4.8 0.74 10.1 2.7 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF3802 PF12290.8 ETN97828.1 - 0.16 12.4 4.4 1 9.9 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3802) ISG65-75 PF11727.8 ETN97828.1 - 0.18 11.0 2.8 0.31 10.2 2.8 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF4446 PF14584.6 ETN97828.1 - 0.18 11.7 4.2 0.13 12.2 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Med21 PF11221.8 ETN97828.1 - 0.37 11.0 7.1 0.098 12.9 4.1 1.6 2 0 0 2 2 1 0 Subunit 21 of Mediator complex Med4 PF10018.9 ETN97828.1 - 0.87 9.2 6.5 0.16 11.6 2.6 1.8 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 DHR10 PF18595.1 ETN97828.1 - 4.6 7.3 12.1 0.3 11.1 6.6 1.9 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF1635 PF07795.11 ETN97828.1 - 6.4 6.6 7.4 2.3 8.0 4.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Ank_2 PF12796.7 ETN97829.1 - 1.8e-07 31.7 0.3 9.8e-07 29.3 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETN97829.1 - 4.3e-06 26.9 1.5 6.3e-05 23.2 0.0 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETN97829.1 - 2.4e-05 24.4 1.9 0.0002 21.5 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Ank PF00023.30 ETN97829.1 - 0.0021 18.4 0.1 0.042 14.3 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 ETN97829.1 - 0.045 14.3 0.2 0.21 12.2 0.2 2.2 1 1 1 2 2 2 0 Ankyrin repeats (many copies) INCENP_ARK-bind PF03941.15 ETN97831.1 - 0.15 12.0 2.0 0.22 11.5 2.0 1.3 1 0 0 1 1 1 0 Inner centromere protein, ARK binding region Roughex PF06020.11 ETN97831.1 - 0.2 10.8 2.5 0.2 10.7 2.5 1.0 1 0 0 1 1 1 0 Drosophila roughex protein PH PF00169.29 ETN97832.1 - 0.00019 21.9 10.3 0.00027 21.4 5.3 3.0 2 1 0 2 2 2 1 PH domain Menin PF05053.13 ETN97832.1 - 0.15 10.3 5.4 0.24 9.7 5.4 1.3 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETN97832.1 - 1.5 9.4 15.0 0.14 12.8 9.3 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain VWA_2 PF13519.6 ETN97833.1 - 0.046 14.4 0.0 1.2 9.9 0.0 2.3 2 0 0 2 2 2 0 von Willebrand factor type A domain NdhL PF10716.9 ETN97833.1 - 0.06 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit Piwi PF02171.17 ETN97834.1 - 2e-20 73.3 0.0 2.4e-20 73.0 0.0 1.1 1 0 0 1 1 1 1 Piwi domain Oberon_cc PF16312.5 ETN97834.1 - 0.049 13.6 0.1 0.072 13.0 0.1 1.2 1 0 0 1 1 1 0 Coiled-coil region of Oberon WD40 PF00400.32 ETN97835.1 - 1.3e-09 38.5 2.0 1.6e-06 28.7 0.4 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF4973 PF16343.5 ETN97835.1 - 0.045 13.8 0.6 0.067 13.2 0.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4973) Presenilin PF01080.17 ETN97837.1 - 0.47 9.2 2.5 0.54 9.0 2.5 1.1 1 0 0 1 1 1 0 Presenilin zf-TRAF PF02176.18 ETN97839.1 - 1.4e-05 25.7 5.6 2.8e-05 24.7 5.6 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger Golgin_A5 PF09787.9 ETN97839.1 - 0.0078 15.7 4.2 0.009 15.5 4.2 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 CC2-LZ PF16516.5 ETN97839.1 - 0.012 15.9 5.9 0.016 15.6 5.9 1.2 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC PF16808.5 ETN97839.1 - 0.018 14.8 4.2 0.018 14.8 4.2 2.3 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase YabA PF06156.13 ETN97839.1 - 0.022 15.4 6.6 0.051 14.2 6.4 1.6 1 1 0 1 1 1 0 Initiation control protein YabA DUF4435 PF14491.6 ETN97839.1 - 0.03 14.2 6.3 0.056 13.3 6.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF4435) DUF4047 PF13256.6 ETN97839.1 - 0.071 13.3 2.3 0.28 11.4 2.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) TraF_2 PF13729.6 ETN97839.1 - 0.094 12.1 0.2 0.11 11.8 0.2 1.1 1 0 0 1 1 1 0 F plasmid transfer operon, TraF, protein FapA PF03961.13 ETN97839.1 - 0.098 11.2 4.4 0.12 11.0 4.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_23 PF13476.6 ETN97839.1 - 0.1 13.1 5.9 0.12 12.9 5.9 1.1 1 0 0 1 1 1 0 AAA domain Csm1_N PF18504.1 ETN97839.1 - 0.56 10.6 8.3 4.4 7.7 8.4 2.0 1 1 1 2 2 2 0 Csm1 N-terminal domain ZapB PF06005.12 ETN97839.1 - 1.8 9.1 11.0 5.8 7.4 10.9 1.8 1 1 0 1 1 1 0 Cell division protein ZapB DivIC PF04977.15 ETN97839.1 - 2.5 7.9 12.1 5.8 6.8 4.6 2.2 1 1 1 2 2 2 0 Septum formation initiator GIT_CC PF16559.5 ETN97839.1 - 3.4 7.6 9.5 1.8 8.5 0.9 2.2 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor HEAT PF02985.22 ETN97840.1 - 1.1e-09 37.7 0.0 0.0015 18.6 0.0 2.2 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 ETN97840.1 - 9.7e-08 32.3 0.0 6.7e-07 29.6 0.0 1.8 1 1 0 1 1 1 1 HEAT repeats Cnd1 PF12717.7 ETN97840.1 - 0.00073 19.6 0.1 0.0026 17.8 0.1 1.7 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETN97840.1 - 0.00084 19.8 0.0 0.16 12.5 0.0 2.1 1 1 1 2 2 2 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETN97840.1 - 0.0014 19.1 0.1 0.18 12.4 0.0 1.9 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region NLE PF08154.12 ETN97840.1 - 0.0056 17.2 1.0 0.015 15.8 0.4 2.1 1 1 1 2 2 2 1 NLE (NUC135) domain S_100 PF01023.19 ETN97840.1 - 0.032 13.9 0.2 7.3 6.4 0.0 2.5 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain HEAT_PBS PF03130.16 ETN97840.1 - 0.037 14.7 0.0 0.97 10.3 0.0 2.5 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat CLASP_N PF12348.8 ETN97840.1 - 0.046 13.3 0.1 0.085 12.4 0.1 1.5 1 1 0 1 1 1 0 CLASP N terminal MutL_C PF08676.11 ETN97840.1 - 0.057 13.2 0.1 0.5 10.1 0.0 1.9 1 1 1 2 2 2 0 MutL C terminal dimerisation domain TIP120 PF08623.10 ETN97840.1 - 0.1 12.3 0.3 0.78 9.5 0.2 1.9 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) Flu_NS1 PF00600.19 ETN97840.1 - 0.13 11.8 0.0 5.3 6.5 0.0 2.0 1 1 1 2 2 2 0 Influenza non-structural protein (NS1) Spore_Cse60 PF10957.8 ETN97840.1 - 0.23 11.5 1.6 2.2 8.4 0.2 2.2 1 1 1 2 2 2 0 Sporulation protein Cse60 Connexin PF00029.19 ETN97841.1 - 0.02 14.7 1.0 0.034 13.9 1.0 1.3 1 0 0 1 1 1 0 Connexin Atrophin-1 PF03154.15 ETN97843.1 - 0.0034 15.8 13.7 0.004 15.5 13.7 1.0 1 0 0 1 1 1 1 Atrophin-1 family MPM1 PF17234.2 ETN97843.1 - 0.027 14.7 10.4 0.035 14.4 10.4 1.1 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 A_deamin PF02137.18 ETN97843.1 - 0.046 13.2 1.1 0.057 12.9 1.1 1.1 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain ERK-JNK_inhib PF15002.6 ETN97843.1 - 0.061 13.0 12.0 0.083 12.6 12.0 1.2 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor DUF3915 PF13054.6 ETN97843.1 - 0.18 11.8 4.2 0.27 11.2 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Rota_VP2 PF05087.12 ETN97843.1 - 0.51 8.4 4.2 0.58 8.2 4.2 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein DUF4637 PF15470.6 ETN97843.1 - 0.94 9.2 7.9 1.1 9.0 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Hid1 PF12722.7 ETN97843.1 - 6.7 4.7 9.4 8.1 4.4 9.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein WD40 PF00400.32 ETN97845.1 - 3.5e-06 27.6 2.5 2.6e-05 24.9 0.5 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETN97845.1 - 7e-05 21.7 0.3 8.9e-05 21.3 0.3 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 BLF1 PF17752.1 ETN97845.1 - 0.083 12.2 0.1 0.15 11.3 0.1 1.5 1 1 0 1 1 1 0 Burkholderia lethal factor 1 Peptidase_C14 PF00656.22 ETN97848.1 - 1.5e-06 28.3 0.0 1.9e-06 28.0 0.0 1.0 1 0 0 1 1 1 1 Caspase domain Peptidase_S49_N PF08496.10 ETN97849.1 - 0.036 14.1 0.9 0.051 13.6 0.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal WD40 PF00400.32 ETN97850.1 - 3.8e-15 56.0 6.5 3e-06 27.8 0.1 4.9 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97850.1 - 0.00045 20.4 1.1 1.8 8.9 0.2 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97850.1 - 0.0033 16.2 0.6 0.48 9.0 0.0 2.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETN97851.1 - 3e-44 148.1 12.8 3.1e-12 46.8 0.1 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97851.1 - 2.9e-19 69.1 0.0 4.3e-06 26.9 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETN97851.1 - 5.8e-08 32.9 0.0 0.00011 22.1 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETN97851.1 - 9.4e-08 31.8 0.8 3 7.9 0.0 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETN97851.1 - 2.3e-07 30.4 0.0 0.45 9.8 0.0 2.9 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETN97851.1 - 1.5e-05 24.1 0.0 1.8 7.4 0.0 3.3 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 ETN97851.1 - 2e-05 24.3 0.0 0.03 13.9 0.0 2.0 1 1 0 2 2 2 2 PQQ-like domain Nup160 PF11715.8 ETN97851.1 - 4.3e-05 22.4 0.0 0.38 9.3 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETN97851.1 - 0.00014 21.4 4.6 11 5.8 0.0 4.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETN97851.1 - 0.00052 18.6 0.0 0.002 16.8 0.0 1.8 1 1 1 2 2 2 1 Cytochrome D1 heme domain GspH PF12019.8 ETN97851.1 - 0.0016 18.8 2.2 1.5 9.3 0.2 3.4 1 1 2 3 3 3 1 Type II transport protein GspH Frtz PF11768.8 ETN97851.1 - 0.0025 16.2 0.0 0.36 9.1 0.0 2.6 1 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz DPPIV_N PF00930.21 ETN97851.1 - 0.0056 15.5 0.0 5.6 5.6 0.0 3.3 1 1 2 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region GAIN_A PF18619.1 ETN97851.1 - 0.0067 16.6 0.0 8.6 6.7 0.0 3.6 4 0 0 4 4 4 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A DUF3475 PF11961.8 ETN97851.1 - 0.011 15.8 0.1 2.5 8.3 0.0 2.7 2 1 1 3 3 2 0 Domain of unknown function (DUF3475) Big_7 PF17957.1 ETN97851.1 - 0.014 16.1 1.0 29 5.5 0.0 3.8 1 1 1 4 4 4 0 Bacterial Ig domain NYD-SP28_assoc PF14775.6 ETN97851.1 - 0.021 14.9 0.1 20 5.4 0.0 3.6 4 0 0 4 4 4 0 Sperm tail C-terminal domain Gmad1 PF10647.9 ETN97851.1 - 0.043 13.6 0.0 50 3.5 0.0 3.5 1 1 1 4 4 4 0 Lipoprotein LpqB beta-propeller domain Me-amine-dh_H PF06433.11 ETN97851.1 - 0.045 12.6 0.0 0.63 8.9 0.0 2.1 1 1 1 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) PH_TFIIH PF08567.11 ETN97851.1 - 0.06 13.7 0.3 13 6.2 0.0 3.2 4 0 0 4 4 4 0 TFIIH p62 subunit, N-terminal domain Germane PF10646.9 ETN97851.1 - 0.076 13.8 0.0 22 5.9 0.0 3.1 2 2 1 3 3 3 0 Sporulation and spore germination Titin_Ig-rpts PF06582.12 ETN97851.1 - 0.11 12.5 0.3 8.5 6.4 0.0 3.0 3 0 0 3 3 3 0 Titin repeat PLD_C PF12357.8 ETN97851.1 - 0.11 12.4 0.3 39 4.3 0.0 3.5 2 1 2 4 4 4 0 Phospholipase D C terminal CSN4_RPN5_eIF3a PF18420.1 ETN97851.1 - 0.39 10.9 5.2 57 4.0 0.1 3.9 4 0 0 4 4 4 0 CSN4/RPN5/eIF3a helix turn helix domain DUF2990 PF11693.8 ETN97852.1 - 0.078 13.2 0.3 0.15 12.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2990) Menin PF05053.13 ETN97853.1 - 1.8 6.9 9.2 1.5 7.0 9.2 1.1 1 0 0 1 1 1 0 Menin RNA_pol_Rpb2_1 PF04563.15 ETN97854.1 - 0.086 12.3 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 RNA polymerase beta subunit HEPN_AbiA_CTD PF18732.1 ETN97855.1 - 0.022 14.7 0.7 0.036 14.0 0.7 1.3 1 0 0 1 1 1 0 HEPN like, Abia C-terminal domain PA_decarbox PF05870.11 ETN97855.1 - 0.024 14.3 0.1 0.039 13.6 0.1 1.3 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) zf-TRAF PF02176.18 ETN97856.1 - 0.00082 20.0 2.0 0.00082 20.0 2.0 3.1 3 1 0 3 3 3 1 TRAF-type zinc finger PKcGMP_CC PF16808.5 ETN97856.1 - 0.0026 17.6 1.2 0.0026 17.6 1.2 2.1 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase HNHc_6 PF16784.5 ETN97857.1 - 0.061 12.9 0.1 0.074 12.6 0.1 1.1 1 0 0 1 1 1 0 Putative HNHc nuclease PPR_3 PF13812.6 ETN97859.1 - 0.0067 16.5 0.3 0.017 15.2 0.3 1.7 1 0 0 1 1 1 1 Pentatricopeptide repeat domain EbsA PF17255.2 ETN97860.1 - 0.051 13.9 0.0 2 8.7 0.0 2.0 2 0 0 2 2 2 0 EbsA-like protein ANAPC4_WD40 PF12894.7 ETN97861.1 - 3.9e-15 55.9 0.2 4.4e-05 23.7 0.0 3.7 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETN97861.1 - 2.2e-14 53.6 7.8 1.1e-05 26.1 1.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat WD40_like PF17005.5 ETN97861.1 - 0.0044 16.4 1.2 0.22 10.8 0.0 2.5 2 1 0 3 3 3 1 WD40-like domain PALB2_WD40 PF16756.5 ETN97861.1 - 0.031 13.2 0.0 1.3 7.9 0.0 2.3 2 0 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Clathrin_propel PF01394.20 ETN97861.1 - 0.064 13.6 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 Clathrin propeller repeat Utp8 PF10395.9 ETN97861.1 - 0.089 11.3 0.0 0.092 11.2 0.0 1.2 1 0 0 1 1 1 0 Utp8 family HSP70 PF00012.20 ETN97862.1 - 2.6e-41 141.5 0.0 2.9e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Fucose_iso_C PF02952.17 ETN97868.1 - 0.025 14.3 0.1 0.059 13.1 0.1 1.8 1 0 0 1 1 1 0 L-fucose isomerase, C-terminal domain PKcGMP_CC PF16808.5 ETN97868.1 - 0.076 12.9 0.0 0.076 12.9 0.0 6.7 8 1 1 9 9 9 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ERM PF00769.19 ETN97868.1 - 0.42 10.4 60.0 1.3 8.8 13.4 3.2 1 1 2 3 3 3 0 Ezrin/radixin/moesin family APG6_N PF17675.1 ETN97868.1 - 4.8 7.7 58.7 0.13 12.8 20.3 3.6 1 1 2 3 3 3 0 Apg6 coiled-coil region Fez1 PF06818.15 ETN97868.1 - 6 7.3 56.2 0.12 12.8 22.2 4.0 1 1 2 3 3 3 0 Fez1 LMF1 PF06762.14 ETN97869.1 - 5.6e-25 88.3 0.4 8.7e-19 67.9 0.3 2.1 2 0 0 2 2 2 2 Lipase maturation factor DUF2512 PF10710.9 ETN97874.1 - 2.5 7.8 8.8 8.5 6.0 4.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2512) Orf78 PF06024.12 ETN97875.1 - 0.81 10.0 0.0 0.81 10.0 0.0 3.6 2 1 2 4 4 4 0 Orf78 (ac78) DUF2330 PF10092.9 ETN97876.1 - 9.5e-74 248.3 0.2 2.9e-72 243.4 0.2 2.0 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2330) zf-TRAF PF02176.18 ETN97877.1 - 7.4e-06 26.6 1.8 7.4e-06 26.6 1.8 2.2 2 2 0 2 2 2 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETN97877.1 - 0.7 10.4 5.8 0.21 12.1 1.9 2.0 1 1 1 2 2 2 0 TRAF-like zinc-finger SBF_like PF13593.6 ETN97878.1 - 0.013 14.8 0.1 0.015 14.6 0.1 1.0 1 0 0 1 1 1 0 SBF-like CPA transporter family (DUF4137) DUF5009 PF16401.5 ETN97878.1 - 0.19 11.2 1.7 0.24 10.8 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5009) AF-4 PF05110.13 ETN97878.1 - 0.73 7.9 6.6 0.76 7.8 6.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein NLRC4_HD2 PF17776.1 ETN97878.1 - 0.85 10.2 4.6 2.1 8.9 4.6 1.8 1 1 0 1 1 1 0 NLRC4 helical domain HD2 SR-25 PF10500.9 ETN97878.1 - 3 7.4 17.8 3.5 7.2 17.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Lipoprotein_3 PF00938.17 ETN97879.1 - 0.0044 17.2 2.0 0.39 10.9 1.1 2.3 1 1 1 2 2 2 2 Lipoprotein WAK PF08488.11 ETN97879.1 - 0.0085 16.6 1.2 0.01 16.4 1.2 1.2 1 0 0 1 1 1 1 Wall-associated kinase Chi-conotoxin PF16981.5 ETN97879.1 - 1.9 8.8 7.8 1.8 8.9 0.2 2.7 3 0 0 3 3 3 0 chi-Conotoxin or t superfamily PPR_2 PF13041.6 ETN97881.1 - 0.063 13.5 0.1 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 PPR repeat family Cys_rich_VLP PF14194.6 ETN97882.1 - 0.029 14.5 0.4 0.043 13.9 0.4 1.2 1 0 0 1 1 1 0 Cysteine-rich VLP Baculo_IE-1 PF05290.11 ETN97885.1 - 0.043 13.8 3.9 0.059 13.3 3.9 1.2 1 0 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) DUF5517 PF17639.2 ETN97885.1 - 0.12 12.6 0.5 0.12 12.6 0.5 1.9 1 1 1 2 2 2 0 Family of unknown function (DUF5517) DUF3437 PF11919.8 ETN97886.1 - 0.26 11.2 1.2 0.38 10.7 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) CAP_GLY PF01302.25 ETN97887.1 - 0.00099 19.1 1.3 0.0011 18.9 0.1 1.7 2 0 0 2 2 2 1 CAP-Gly domain BCAS2 PF05700.11 ETN97888.1 - 5.7e-05 22.9 0.7 8.7e-05 22.3 0.6 1.4 1 1 0 1 1 1 1 Breast carcinoma amplified sequence 2 (BCAS2) DUF3416 PF11896.8 ETN97888.1 - 0.016 15.5 0.0 0.019 15.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3416) MLANA PF14991.6 ETN97888.1 - 0.068 13.5 0.1 0.14 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein melan-A Tetraspanin PF00335.20 ETN97888.1 - 0.087 12.5 1.6 0.14 11.9 1.6 1.3 1 0 0 1 1 1 0 Tetraspanin family DUF4750 PF15938.5 ETN97888.1 - 2.9 7.6 4.3 4.7 6.9 4.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) MAJIN PF15077.6 ETN97889.1 - 1.9 8.3 7.5 2 8.1 7.5 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein FAM176 PF14851.6 ETN97889.1 - 1.9 8.2 5.2 2.2 7.9 5.2 1.3 1 0 0 1 1 1 0 FAM176 family BLOC1_2 PF10046.9 ETN97890.1 - 0.00033 20.9 2.8 0.00033 20.9 2.8 1.7 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4200 PF13863.6 ETN97890.1 - 0.017 15.5 2.1 0.017 15.5 2.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DASH_Dam1 PF08653.10 ETN97890.1 - 0.022 14.5 0.3 0.046 13.5 0.2 1.6 1 1 0 1 1 1 0 DASH complex subunit Dam1 Med15_fungi PF05397.12 ETN97890.1 - 0.026 14.8 5.4 0.03 14.6 5.4 1.3 1 1 0 1 1 1 0 Mediator complex subunit 15 Rop-like PF05082.13 ETN97890.1 - 0.033 14.0 1.4 3.2 7.7 0.1 2.5 2 1 0 2 2 2 0 Rop-like LZ3wCH PF18517.1 ETN97890.1 - 0.037 14.1 0.2 0.037 14.1 0.2 1.9 1 1 1 2 2 2 0 Leucine zipper with capping helix domain DIM1 PF02966.16 ETN97890.1 - 0.038 13.8 0.2 0.038 13.8 0.2 1.4 2 0 0 2 2 2 0 Mitosis protein DIM1 FliD_N PF02465.18 ETN97890.1 - 0.042 14.5 4.5 0.052 14.2 4.5 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF4140 PF13600.6 ETN97890.1 - 0.044 14.2 0.1 0.067 13.6 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) USP8_interact PF08941.10 ETN97890.1 - 0.095 12.5 3.3 0.11 12.3 3.3 1.1 1 0 0 1 1 1 0 USP8 interacting DivIC PF04977.15 ETN97890.1 - 0.12 12.1 5.3 0.21 11.4 4.6 1.8 1 1 1 2 2 2 0 Septum formation initiator FlaC_arch PF05377.11 ETN97890.1 - 0.21 12.0 6.2 0.065 13.6 2.2 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF2232 PF09991.9 ETN97890.1 - 0.43 9.7 1.1 0.52 9.4 1.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) SR-25 PF10500.9 ETN97891.1 - 0.44 10.1 26.8 0.28 10.8 24.9 1.6 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Neur_chan_memb PF02932.16 ETN97891.1 - 8 6.4 6.8 11 5.9 6.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3161 PF11362.8 ETN97892.1 - 0.00089 19.2 1.3 0.005 16.8 0.9 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF3161) zf-CpG_bind_C PF12269.8 ETN97893.1 - 0.047 13.5 8.2 0.049 13.4 8.2 1.0 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain Ribosomal_L19 PF01245.20 ETN97894.1 - 2e-07 30.9 0.0 2.3e-07 30.7 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L19 Flavi_NS4B PF01349.17 ETN97895.1 - 0.078 12.4 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4B NACHT PF05729.12 ETN97895.1 - 0.1 12.5 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 NACHT domain Peptidase_C14 PF00656.22 ETN97896.1 - 2e-07 31.2 0.2 4e-07 30.2 0.2 1.4 1 1 0 1 1 1 1 Caspase domain SR-25 PF10500.9 ETN97897.1 - 0.0017 18.0 8.5 0.0029 17.2 8.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein TMEM237 PF15383.6 ETN97897.1 - 0.031 13.4 2.2 0.044 12.9 2.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 237 IMUP PF15761.5 ETN97897.1 - 0.089 13.5 10.9 0.14 12.9 10.9 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein ICMT PF04140.14 ETN97898.1 - 0.017 15.6 0.1 0.017 15.6 0.1 2.0 2 1 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family ECSCR PF15820.5 ETN97899.1 - 0.037 13.8 2.3 0.043 13.6 0.3 2.2 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Smim3 PF17307.2 ETN97899.1 - 9.6 5.8 8.3 0.52 9.8 2.7 1.7 2 0 0 2 2 2 0 Small integral membrane protein 3 XkdW PF09636.10 ETN97900.1 - 0.0022 18.1 0.0 0.0024 17.9 0.0 1.0 1 0 0 1 1 1 1 XkdW protein TIP120 PF08623.10 ETN97900.1 - 0.019 14.7 0.0 0.02 14.6 0.0 1.1 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) HEAT PF02985.22 ETN97900.1 - 0.021 15.1 0.0 0.7 10.3 0.0 2.4 3 0 0 3 3 3 0 HEAT repeat NLE PF08154.12 ETN97900.1 - 0.066 13.8 0.0 8.9 6.9 0.0 2.1 2 0 0 2 2 2 0 NLE (NUC135) domain TENA_THI-4 PF03070.16 ETN97900.1 - 0.087 12.6 0.0 0.098 12.5 0.0 1.0 1 0 0 1 1 1 0 TENA/THI-4/PQQC family RTP1_C1 PF10363.9 ETN97900.1 - 0.091 12.9 0.0 0.091 12.9 0.0 1.1 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 ETN97900.1 - 0.1 13.0 0.0 0.16 12.4 0.0 1.3 1 1 0 1 1 1 0 HEAT repeats Med23 PF11573.8 ETN97900.1 - 0.17 9.5 0.0 0.19 9.4 0.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 23 zf-TRAF PF02176.18 ETN97902.1 - 5.2e-06 27.1 1.4 5.2e-06 27.1 1.4 3.0 3 0 0 3 3 3 1 TRAF-type zinc finger WD40 PF00400.32 ETN97902.1 - 6.3 7.9 6.2 4.5 8.3 0.4 3.4 4 0 0 4 4 4 0 WD domain, G-beta repeat TPR_12 PF13424.6 ETN97903.1 - 4.2e-26 91.0 0.2 1e-12 48.2 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97903.1 - 8.7e-21 73.1 0.0 0.00015 21.5 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97903.1 - 1.2e-14 53.2 18.4 5.8e-05 23.0 0.3 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97903.1 - 1.1e-13 50.4 18.6 6e-05 22.7 0.5 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97903.1 - 4.6e-12 45.1 0.7 0.016 15.2 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97903.1 - 1.7e-09 37.1 13.5 0.00074 19.4 0.3 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97903.1 - 5.1e-09 35.9 4.6 0.038 14.4 0.0 4.7 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97903.1 - 5.1e-06 26.8 0.5 0.37 11.5 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETN97903.1 - 0.00028 20.8 6.1 0.089 12.8 0.4 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97903.1 - 0.00072 19.2 16.0 0.6 9.8 0.6 5.1 4 2 1 5 5 5 2 TPR repeat Mob_Pre PF01076.19 ETN97903.1 - 0.00092 19.1 1.2 0.001 18.9 0.1 1.5 2 0 0 2 2 2 1 Plasmid recombination enzyme PPR PF01535.20 ETN97903.1 - 0.0011 19.1 7.6 0.49 10.8 0.2 3.7 4 0 0 4 4 4 2 PPR repeat TPR_16 PF13432.6 ETN97903.1 - 0.0012 19.4 0.0 1.1 10.0 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN97903.1 - 0.0028 17.8 1.0 0.45 10.8 0.1 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETN97903.1 - 0.0068 16.9 0.9 6.5 7.4 0.1 3.0 3 1 0 3 3 3 2 Domain of unknown function (DUF4810) KH_4 PF13083.6 ETN97903.1 - 0.0078 16.1 0.0 1.8 8.5 0.0 3.0 3 0 0 3 3 3 1 KH domain TPR_14 PF13428.6 ETN97903.1 - 0.024 15.4 0.0 1.4 9.9 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF5621 PF18532.1 ETN97904.1 - 0.01 15.8 0.4 0.012 15.5 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5621) ECH_2 PF16113.5 ETN97906.1 - 4.5e-89 299.2 0.0 4.9e-89 299.1 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ETN97906.1 - 6.5e-13 48.6 0.1 1.5e-11 44.1 0.0 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase Pkinase PF00069.25 ETN97908.1 - 4.4e-11 42.6 0.0 5.5e-11 42.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 ETN97909.1 - 1.1e-06 29.1 1.2 5.1e-06 26.9 0.9 2.3 2 1 0 2 2 2 1 PH domain Ribosomal_L12_N PF16320.5 ETN97909.1 - 0.011 15.4 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain PH_6 PF15406.6 ETN97909.1 - 0.013 15.8 0.0 0.025 14.9 0.0 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ETN97909.1 - 0.11 12.9 2.0 9.8 6.7 0.2 3.2 2 1 2 4 4 4 0 Pleckstrin homology domain KA1 PF02149.19 ETN97910.1 - 0.2 11.5 0.0 0.41 10.5 0.0 1.5 1 0 0 1 1 1 0 Kinase associated domain 1 DUF4709 PF15821.5 ETN97911.1 - 0.017 15.4 2.4 0.097 13.0 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4709) PP2C_2 PF13672.6 ETN97911.1 - 0.15 11.7 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein phosphatase 2C zf-TRAF PF02176.18 ETN97914.1 - 4.1e-05 24.2 4.9 7.4e-05 23.4 4.9 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger DUF4200 PF13863.6 ETN97914.1 - 0.00045 20.6 4.1 0.00059 20.2 4.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Bap31_Bap29_C PF18035.1 ETN97914.1 - 0.01 15.9 9.8 0.015 15.3 9.8 1.3 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain GPS2_interact PF15784.5 ETN97914.1 - 0.014 15.9 3.2 0.019 15.4 3.2 1.2 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Csm1_N PF18504.1 ETN97914.1 - 0.027 14.8 6.5 0.047 14.0 6.5 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain DUF3426 PF11906.8 ETN97914.1 - 0.1 12.7 0.6 0.16 12.1 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3426) DivIC PF04977.15 ETN97914.1 - 2.5 7.9 7.1 3.4 7.5 6.6 1.5 1 1 0 1 1 1 0 Septum formation initiator KGK PF08872.10 ETN97915.1 - 0.038 14.5 0.6 0.071 13.6 0.6 1.4 1 0 0 1 1 1 0 KGK domain Spore_SspJ PF09575.10 ETN97916.1 - 0.11 12.8 7.9 0.17 12.3 0.5 2.3 2 0 0 2 2 2 0 Small spore protein J (Spore_SspJ) Imm5 PF14423.6 ETN97916.1 - 0.16 12.2 2.4 0.19 11.9 2.4 1.1 1 0 0 1 1 1 0 Immunity protein Imm5 Mucin PF01456.17 ETN97916.1 - 0.45 10.5 19.6 0.54 10.3 19.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein CENP-U PF13097.6 ETN97916.1 - 3.9 7.4 15.3 4.7 7.1 15.3 1.0 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit DUF3138 PF11336.8 ETN97916.1 - 4.5 5.8 8.7 4.9 5.6 8.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) FSA_C PF10479.9 ETN97916.1 - 6.3 4.8 11.2 6.6 4.7 11.2 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF410 PF04190.13 ETN97917.1 - 0.011 15.6 0.5 0.012 15.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF410) Flavodoxin_1 PF00258.25 ETN97918.1 - 2.1e-15 57.2 0.1 3.5e-15 56.5 0.1 1.3 1 0 0 1 1 1 1 Flavodoxin Flavodoxin_5 PF12724.7 ETN97918.1 - 0.011 16.0 0.5 0.037 14.3 0.1 1.8 2 0 0 2 2 2 0 Flavodoxin domain RPN2_C PF18004.1 ETN97918.1 - 0.13 12.2 6.4 1.9 8.4 0.0 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain eIF3_p135 PF12807.7 ETN97918.1 - 0.18 11.9 3.8 0.72 9.9 0.5 2.2 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 RelA_SpoT PF04607.17 ETN97919.1 - 0.0034 17.6 0.6 0.0087 16.3 0.6 1.7 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins CpXC PF14353.6 ETN97919.1 - 0.14 12.2 2.5 1.7 8.7 0.0 2.5 3 0 0 3 3 3 0 CpXC protein Glyco_hydro_92 PF07971.12 ETN97922.1 - 0.042 12.8 0.8 0.045 12.7 0.8 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 Mss4 PF04421.13 ETN97924.1 - 0.45 10.7 4.0 0.22 11.7 0.3 2.3 3 0 0 3 3 3 0 Mss4 protein HisK_sensor PF18698.1 ETN97924.1 - 0.55 10.6 8.1 3 8.2 1.4 2.6 1 1 0 2 2 2 0 Histidine kinase sensor domain CopC PF04234.12 ETN97925.1 - 0.12 13.4 0.0 0.16 13.1 0.0 1.2 1 0 0 1 1 1 0 CopC domain WD40 PF00400.32 ETN97926.1 - 0.12 13.3 0.6 0.49 11.3 0.0 2.2 2 1 1 3 3 3 0 WD domain, G-beta repeat WD40 PF00400.32 ETN97927.1 - 1.6e-23 82.5 21.5 3.9e-06 27.5 2.2 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97927.1 - 1.8e-07 31.3 0.9 0.0075 16.5 0.0 3.4 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN97927.1 - 7.3e-05 21.6 8.6 0.0093 14.7 2.9 3.4 2 2 1 3 3 3 3 Nucleoporin Nup120/160 TPR_12 PF13424.6 ETN97930.1 - 1.6e-50 169.3 19.7 1.5e-21 76.4 0.6 4.5 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97930.1 - 1.3e-43 145.1 42.0 3.5e-10 39.3 2.9 6.1 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97930.1 - 7.9e-40 133.7 6.4 5.5e-09 35.6 0.0 6.0 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97930.1 - 5.1e-37 123.0 34.2 5.2e-09 35.5 0.9 6.0 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97930.1 - 3.5e-32 107.9 36.9 2e-08 33.8 3.3 6.1 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97930.1 - 7.4e-28 94.5 14.1 2e-05 24.3 0.0 6.1 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97930.1 - 1.5e-19 69.3 10.4 6.4e-05 23.3 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETN97930.1 - 1.8e-19 70.1 0.2 3.9e-05 24.2 0.0 4.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97930.1 - 6.4e-17 60.8 0.0 0.0024 18.6 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97930.1 - 7.2e-17 60.5 26.6 0.0071 16.7 0.1 6.7 5 3 1 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97930.1 - 1.3e-16 60.0 49.4 0.00067 19.3 0.4 9.4 5 4 5 10 10 10 9 TPR repeat SHNi-TPR PF10516.9 ETN97930.1 - 7.5e-11 41.3 4.0 0.00036 19.9 0.1 4.9 5 0 0 5 5 5 2 SHNi-TPR SNAP PF14938.6 ETN97930.1 - 2.9e-08 33.5 13.0 8.2e-05 22.2 8.4 2.8 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETN97930.1 - 6.8e-08 32.5 15.7 0.0081 16.2 0.3 5.0 5 0 0 5 5 5 3 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETN97930.1 - 2.4e-07 30.9 24.3 0.0024 18.1 2.2 4.2 1 1 3 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 ETN97930.1 - 1.8e-06 27.7 14.0 0.0045 16.5 1.1 4.3 3 1 0 4 4 4 3 Meiosis protein SPO22/ZIP4 like HTH_Bact PF18768.1 ETN97930.1 - 2e-06 27.3 7.9 0.19 11.3 0.2 5.3 5 0 0 5 5 5 1 Helix-turn-helix bacterial domain TPR_19 PF14559.6 ETN97930.1 - 4.3e-06 27.1 4.1 1.2 9.7 0.8 4.6 2 1 3 5 5 5 2 Tetratricopeptide repeat SMBP PF16785.5 ETN97930.1 - 5.7e-06 26.5 0.1 0.00016 21.8 0.2 2.4 2 0 0 2 2 2 1 Small metal-binding protein TPR_5 PF12688.7 ETN97930.1 - 3.1e-05 24.2 0.2 0.0023 18.1 0.1 3.1 2 1 1 3 3 3 1 Tetratrico peptide repeat DUF2225 PF09986.9 ETN97930.1 - 3.9e-05 23.5 16.0 0.0033 17.2 6.6 2.5 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETN97930.1 - 5.3e-05 23.1 23.1 1.3 8.8 0.1 5.0 4 1 1 5 5 5 4 Domain of unknown function (DUF5113) BRO1 PF03097.18 ETN97930.1 - 0.00055 18.9 6.9 0.0036 16.2 1.6 2.8 1 1 1 2 2 2 1 BRO1-like domain TPR_MalT PF17874.1 ETN97930.1 - 0.002 17.6 0.0 0.38 10.1 0.0 2.1 1 1 1 2 2 2 1 MalT-like TPR region Sel1 PF08238.12 ETN97930.1 - 0.002 18.7 24.3 1.2 9.9 0.9 6.2 5 2 0 5 5 5 1 Sel1 repeat Prefoldin PF02996.17 ETN97930.1 - 0.0055 16.6 9.0 15 5.5 0.1 4.6 4 1 0 5 5 5 0 Prefoldin subunit DUF627 PF04781.12 ETN97930.1 - 0.018 15.1 10.7 0.12 12.3 2.6 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF627) RPN7 PF10602.9 ETN97930.1 - 0.025 14.3 13.4 0.16 11.7 1.3 4.1 2 2 2 4 4 4 0 26S proteasome subunit RPN7 TPR_3 PF07720.12 ETN97930.1 - 0.036 14.1 34.6 0.17 11.9 2.5 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF2959 PF11172.8 ETN97930.1 - 0.051 13.7 2.3 2.6 8.2 0.1 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF2959) mit_SMPDase PF14724.6 ETN97930.1 - 0.053 11.5 1.1 2.9 5.8 0.1 2.0 1 1 1 2 2 2 0 Mitochondrial-associated sphingomyelin phosphodiesterase PPR PF01535.20 ETN97930.1 - 0.09 13.1 9.7 6.8 7.2 0.1 5.6 5 2 1 6 6 6 0 PPR repeat Sda PF08970.10 ETN97930.1 - 0.19 11.5 7.5 33 4.3 0.1 4.7 4 1 0 4 4 4 0 Sporulation inhibitor A NSF PF02071.20 ETN97930.1 - 0.51 11.3 12.3 11 7.3 0.2 6.0 5 1 1 6 6 5 0 Aromatic-di-Alanine (AdAR) repeat BAR_3 PF16746.5 ETN97930.1 - 1.3 8.7 8.5 15 5.2 4.3 3.2 1 1 3 4 4 4 0 BAR domain of APPL family DUF5344 PF17279.2 ETN97930.1 - 2.7 8.6 7.7 2.7 8.6 1.7 3.5 1 1 3 4 4 4 0 Family of unknown function (DUF5344) Fis1_TPR_C PF14853.6 ETN97930.1 - 2.7 8.1 27.1 1.1 9.4 2.5 4.5 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat Mob_Pre PF01076.19 ETN97930.1 - 2.8 7.7 12.9 2.8 7.7 0.9 2.7 1 1 1 3 3 3 0 Plasmid recombination enzyme UVR PF02151.19 ETN97930.1 - 5.8 6.8 7.3 24 4.8 0.1 4.0 4 0 0 4 4 4 0 UvrB/uvrC motif CLASP_N PF12348.8 ETN97931.1 - 0.0061 16.1 0.1 0.0064 16.1 0.1 1.1 1 0 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 ETN97931.1 - 0.029 14.6 0.0 4 7.9 0.0 2.4 2 0 0 2 2 2 0 HEAT repeat HEAT_2 PF13646.6 ETN97931.1 - 0.12 12.8 0.0 6.6 7.2 0.0 2.0 1 1 1 2 2 2 0 HEAT repeats NAD_binding_7 PF13241.6 ETN97933.1 - 0.74 10.3 2.8 4.3 7.8 0.4 2.1 1 1 1 2 2 2 0 Putative NAD(P)-binding zf_C2H2_6 PF18450.1 ETN97933.1 - 6.5 6.6 10.1 0.44 10.3 4.2 2.2 2 0 0 2 2 2 0 Zinc Finger domain zf-CCHC PF00098.23 ETN97935.1 - 0.00057 19.8 8.4 0.00062 19.7 4.8 2.2 2 0 0 2 2 2 1 Zinc knuckle gag-asp_proteas PF13975.6 ETN97935.1 - 0.027 15.0 0.0 0.05 14.2 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF4838 PF16126.5 ETN97935.1 - 0.049 13.0 0.3 0.059 12.7 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) Asp_protease_2 PF13650.6 ETN97935.1 - 0.17 12.5 0.0 0.32 11.7 0.0 1.4 1 0 0 1 1 1 0 Aspartyl protease Exo_endo_phos_2 PF14529.6 ETN97936.1 - 5.7e-05 22.9 0.3 5.7e-05 22.9 0.3 1.8 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase AKAP28 PF14469.6 ETN97936.1 - 0.46 10.3 4.1 0.27 11.0 0.3 2.4 2 1 1 3 3 3 0 28 kDa A-kinase anchor Atg31 PF09795.9 ETN97937.1 - 0.023 14.7 0.5 0.031 14.3 0.4 1.4 1 1 0 1 1 1 0 Autophagy-related protein 31 GNAT_C PF18164.1 ETN97937.1 - 0.079 12.7 0.2 0.2 11.3 0.1 1.7 1 1 1 2 2 2 0 GNAT-like C-terminal domain TPR_12 PF13424.6 ETN97938.1 - 1.3e-54 182.4 10.8 1.4e-13 51.0 0.2 6.0 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97938.1 - 8.4e-34 114.5 0.0 9.5e-08 31.7 0.0 8.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97938.1 - 3.9e-29 98.4 35.1 0.00016 21.6 0.1 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97938.1 - 1.2e-27 94.5 38.6 5.4e-07 29.2 1.2 9.9 9 1 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97938.1 - 2.3e-27 92.9 10.4 0.00012 21.9 0.0 8.8 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97938.1 - 6.2e-25 85.3 33.0 0.0018 18.3 0.1 9.6 9 1 0 9 9 9 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97938.1 - 3.5e-12 46.0 0.0 5 8.2 0.0 7.7 6 2 2 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97938.1 - 3.2e-08 33.7 5.0 5.3 7.9 0.0 7.7 8 1 1 9 9 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97938.1 - 3.7e-08 33.2 5.9 2.3 8.8 1.4 7.2 7 1 0 7 7 6 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97938.1 - 3e-07 30.4 9.9 0.23 11.2 0.0 5.6 6 0 0 6 6 6 2 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETN97938.1 - 3.3e-07 30.0 0.0 1.9e-05 24.2 0.0 2.7 2 1 0 2 2 2 1 MalT-like TPR region TPR_11 PF13414.6 ETN97938.1 - 4.6e-07 29.4 25.2 0.046 13.4 0.1 8.3 9 2 1 10 10 10 4 TPR repeat TPR_16 PF13432.6 ETN97938.1 - 2.9e-06 27.8 0.0 4.5 8.0 0.0 5.4 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97938.1 - 0.00013 22.4 0.1 34 5.1 0.0 4.8 3 1 0 4 4 4 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETN97938.1 - 0.00014 21.7 14.2 0.028 14.1 1.5 4.3 1 1 1 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 ETN97938.1 - 0.00069 20.2 10.1 0.91 10.3 0.2 6.1 5 1 1 6 6 5 1 Sel1 repeat SHNi-TPR PF10516.9 ETN97938.1 - 0.0014 18.0 8.5 3.8 7.1 0.0 6.8 9 0 0 9 9 9 1 SHNi-TPR SPO22 PF08631.10 ETN97938.1 - 0.0016 18.0 3.8 0.09 12.2 3.8 3.2 1 1 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like DUF3856 PF12968.7 ETN97938.1 - 0.0066 16.5 6.4 2 8.5 0.5 3.9 2 2 2 4 4 4 2 Domain of Unknown Function (DUF3856) TPR_21 PF09976.9 ETN97938.1 - 0.0072 16.1 0.2 1.2 8.8 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat-like domain TOM20_plant PF06552.12 ETN97938.1 - 0.068 12.9 3.3 3.5 7.3 0.1 3.3 3 1 1 4 4 4 0 Plant specific mitochondrial import receptor subunit TOM20 DUF627 PF04781.12 ETN97938.1 - 0.13 12.3 5.7 4.4 7.4 0.2 3.5 4 1 0 4 4 4 0 Protein of unknown function (DUF627) Mob_Pre PF01076.19 ETN97938.1 - 0.13 12.1 9.5 0.6 9.9 1.2 3.4 3 1 1 4 4 4 0 Plasmid recombination enzyme DUF3889 PF13028.6 ETN97938.1 - 0.39 10.7 4.0 17 5.4 0.2 3.1 2 1 0 3 3 3 0 Protein of unknown function (DUF3889) MIT PF04212.18 ETN97938.1 - 0.67 10.1 19.4 4.8 7.3 0.2 6.9 9 0 0 9 9 8 0 MIT (microtubule interacting and transport) domain DUF1296 PF06972.11 ETN97939.1 - 0.045 13.9 0.3 0.082 13.1 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1296) Phosphodiest PF01663.22 ETN97940.1 - 4.7e-33 115.3 0.3 5.9e-33 114.9 0.3 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ETN97940.1 - 0.00021 20.8 0.0 0.00025 20.5 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ETN97940.1 - 0.012 15.0 0.2 0.02 14.3 0.2 1.5 1 1 0 1 1 1 0 Sulfatase DUF229 PF02995.17 ETN97940.1 - 0.086 11.4 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Phosphodiest PF01663.22 ETN97941.1 - 4.7e-33 115.3 0.3 5.9e-33 114.9 0.3 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ETN97941.1 - 0.00021 20.8 0.0 0.00025 20.5 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ETN97941.1 - 0.012 15.0 0.2 0.02 14.3 0.2 1.5 1 1 0 1 1 1 0 Sulfatase DUF229 PF02995.17 ETN97941.1 - 0.086 11.4 0.0 0.1 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) Symplekin_C PF12295.8 ETN97942.1 - 0.0049 17.0 0.2 0.0058 16.7 0.2 1.1 1 0 0 1 1 1 1 Symplekin tight junction protein C terminal Peptidase_C50 PF03568.17 ETN97942.1 - 0.0086 15.2 1.8 0.011 15.0 1.8 1.0 1 0 0 1 1 1 1 Peptidase family C50 SICA_beta PF12878.7 ETN97942.1 - 0.011 16.0 0.2 0.014 15.6 0.2 1.3 1 0 0 1 1 1 0 SICA extracellular beta domain YlbD_coat PF14071.6 ETN97942.1 - 0.011 16.0 1.7 0.015 15.5 1.7 1.2 1 0 0 1 1 1 0 Putative coat protein Mu-like_Pro PF10123.9 ETN97942.1 - 0.16 11.5 3.1 0.13 11.8 2.0 1.4 1 1 1 2 2 2 0 Mu-like prophage I protein dDENN PF03455.19 ETN97943.1 - 1.6e-07 31.2 2.6 3.1e-07 30.3 2.6 1.5 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.6 ETN97943.1 - 2.7e-05 24.2 0.0 0.00035 20.7 0.0 2.5 3 0 0 3 3 3 1 PPR repeat family PPR_3 PF13812.6 ETN97943.1 - 0.18 11.9 0.0 3.2 7.9 0.0 2.3 2 0 0 2 2 2 0 Pentatricopeptide repeat domain DUF3584 PF12128.8 ETN97945.1 - 0.0087 13.6 26.7 0.012 13.2 26.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF3410 PF11890.8 ETN97945.1 - 0.37 10.6 2.2 1.7 8.5 1.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3410) FAM76 PF16046.5 ETN97945.1 - 0.99 8.7 26.6 0.92 8.8 24.2 2.2 1 1 0 1 1 1 0 FAM76 protein Exonuc_VII_L PF02601.15 ETN97945.1 - 2 7.9 24.9 8.3 5.9 24.9 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETN97945.1 - 2.1 8.4 22.5 0.21 11.6 10.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 ETN97945.1 - 2.9 8.0 42.9 0.6 10.2 31.5 2.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_M15_3 PF08291.11 ETN97946.1 - 4.6e-15 55.7 0.0 1.1e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase M15 Plasmodium_Vir PF05795.11 ETN97946.1 - 0.00022 20.8 0.2 0.00022 20.8 0.2 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Orf78 PF06024.12 ETN97946.1 - 0.0006 20.1 0.5 0.001 19.3 0.5 1.3 1 0 0 1 1 1 1 Orf78 (ac78) DUF4448 PF14610.6 ETN97946.1 - 0.0017 18.1 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 ETN97946.1 - 0.002 18.1 1.2 0.003 17.4 1.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family DUF5305 PF17231.2 ETN97946.1 - 0.0031 16.9 0.2 0.0051 16.2 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF2520 PF10728.9 ETN97946.1 - 0.005 16.6 0.0 0.0089 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2520) Glycophorin_A PF01102.18 ETN97946.1 - 0.0065 16.7 0.3 0.011 15.9 0.3 1.3 1 0 0 1 1 1 1 Glycophorin A CD34_antigen PF06365.12 ETN97946.1 - 0.0088 15.6 1.3 0.024 14.2 1.3 1.7 1 1 0 1 1 1 1 CD34/Podocalyxin family Amnionless PF14828.6 ETN97946.1 - 0.014 14.2 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Amnionless RIFIN PF02009.16 ETN97946.1 - 0.029 14.3 0.1 0.03 14.2 0.1 1.2 1 0 0 1 1 1 0 Rifin Chordopox_A13L PF05961.11 ETN97946.1 - 0.038 14.2 0.6 0.1 12.8 0.4 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Peptidase_M56 PF05569.11 ETN97946.1 - 0.066 12.4 0.1 0.088 12.0 0.1 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 DAG1 PF05454.11 ETN97946.1 - 0.096 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) LRRC37AB_C PF14914.6 ETN97946.1 - 0.16 11.9 0.6 0.24 11.3 0.6 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Type_ISP_C PF18135.1 ETN97947.1 - 0.025 13.6 0.3 0.027 13.5 0.3 1.1 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain Hus1 PF04005.12 ETN97948.1 - 0.15 11.2 0.2 0.16 11.0 0.2 1.1 1 0 0 1 1 1 0 Hus1-like protein Secretin_N_2 PF07655.13 ETN97948.1 - 0.47 11.0 2.6 1.6 9.3 2.6 1.9 1 1 0 1 1 1 0 Secretin N-terminal domain Pox_E10 PF04805.12 ETN97949.1 - 0.025 14.4 0.2 0.064 13.1 0.2 1.7 1 0 0 1 1 1 0 E10-like protein conserved region Pentapeptide PF00805.22 ETN97950.1 - 0.0001 21.8 0.0 0.00022 20.8 0.0 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) BP28CT PF08146.12 ETN97950.1 - 0.028 14.3 0.6 0.053 13.4 0.3 1.6 1 1 0 2 2 2 0 BP28CT (NUC211) domain B PF02216.16 ETN97952.1 - 2.2e-09 37.2 33.8 1.5e+02 2.5 0.0 17.5 1 1 19 20 20 20 0 B domain Colicin_Pyocin PF01320.18 ETN97952.1 - 4.5e-07 29.9 12.5 20 5.3 0.1 9.6 1 1 12 13 13 13 1 Colicin immunity protein / pyocin immunity protein RA PF00788.23 ETN97952.1 - 5.1e-06 27.0 19.2 40 4.9 0.4 10.5 1 1 10 11 11 11 0 Ras association (RalGDS/AF-6) domain DUF1961 PF09224.11 ETN97952.1 - 6.3e-05 22.5 22.6 2.8 7.3 0.3 6.9 1 1 9 10 10 10 8 Domain of unknown function (DUF1961) Cpn10 PF00166.21 ETN97952.1 - 0.0013 18.7 7.9 38 4.4 0.1 6.3 1 1 10 11 11 11 0 Chaperonin 10 Kd subunit Mtr2 PF10429.9 ETN97952.1 - 0.51 10.3 32.3 37 4.2 0.5 7.7 1 1 9 10 10 10 0 Nuclear pore RNA shuttling protein Mtr2 Peptidase_M22 PF00814.25 ETN97955.1 - 0.005 16.6 0.0 0.0056 16.4 0.0 1.0 1 0 0 1 1 1 1 Glycoprotease family HD_6 PF18019.1 ETN97957.1 - 0.0099 16.0 0.0 3.5 7.7 0.0 2.1 2 0 0 2 2 2 2 HD domain Kelch_6 PF13964.6 ETN97957.1 - 0.014 15.7 0.2 0.21 11.9 0.1 2.6 2 0 0 2 2 2 0 Kelch motif ANAPC15 PF15243.6 ETN97959.1 - 0.67 10.4 12.8 0.28 11.6 3.7 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 SAPS PF04499.15 ETN97959.1 - 5.4 5.7 12.8 6.4 5.4 12.8 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MFMR_assoc PF16596.5 ETN97959.1 - 9.4 6.7 13.7 0.35 11.3 1.7 2.1 1 1 1 2 2 2 0 Disordered region downstream of MFMR Sec20 PF03908.13 ETN97960.1 - 0.0034 17.3 3.1 0.0054 16.6 1.8 2.0 2 0 0 2 2 2 1 Sec20 Syntaxin-6_N PF09177.11 ETN97960.1 - 0.023 15.3 3.9 3.7 8.2 0.2 2.8 2 0 0 2 2 2 0 Syntaxin 6, N-terminal PCRF PF03462.18 ETN97960.1 - 0.037 13.9 0.8 0.037 13.9 0.8 1.9 2 0 0 2 2 2 0 PCRF domain His_kinase PF06580.13 ETN97960.1 - 0.33 11.3 2.2 48 4.4 0.0 3.5 3 1 0 3 3 3 0 Histidine kinase Cauli_VI PF01693.16 ETN97961.1 - 0.21 11.9 7.1 0.34 11.2 0.8 3.0 3 0 0 3 3 3 0 Caulimovirus viroplasmin Folliculin PF11704.8 ETN97962.1 - 0.66 9.8 5.4 13 5.6 4.1 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport HemX PF04375.14 ETN97962.1 - 2.9 7.1 9.5 3.9 6.7 9.5 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TPR_12 PF13424.6 ETN97963.1 - 1.6e-54 182.1 0.5 7e-20 71.1 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97963.1 - 2.3e-46 154.4 0.1 1.3e-09 37.6 0.4 5.0 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97963.1 - 2.2e-39 130.6 1.4 1.5e-08 34.1 0.0 5.1 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97963.1 - 1.5e-38 129.0 23.4 2.1e-09 36.8 2.5 5.1 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97963.1 - 1.6e-28 96.5 25.3 3.2e-07 30.0 1.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97963.1 - 6.9e-23 78.9 15.3 7.5e-07 28.8 0.2 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97963.1 - 1.1e-13 51.3 10.1 0.007 16.2 0.1 4.5 5 0 0 5 5 5 4 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETN97963.1 - 5.5e-13 48.4 26.6 0.0029 17.3 0.6 7.0 5 2 2 7 7 7 6 TPR repeat TPR_17 PF13431.6 ETN97963.1 - 2.1e-12 46.5 7.8 0.00076 19.7 0.1 5.5 4 2 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97963.1 - 5.4e-10 39.2 0.0 0.32 11.9 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat RPN7 PF10602.9 ETN97963.1 - 1.3e-07 31.5 6.5 0.0014 18.4 0.3 3.7 1 1 2 3 3 3 3 26S proteasome subunit RPN7 TPR_6 PF13174.6 ETN97963.1 - 1.8e-06 28.2 0.2 0.08 13.6 0.0 4.5 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETN97963.1 - 3.5e-06 26.9 8.6 0.008 16.1 0.4 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN97963.1 - 7.9e-06 26.0 6.1 0.21 11.9 0.2 4.1 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETN97963.1 - 2.3e-05 24.9 0.0 0.12 13.0 0.0 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat DUF357 PF04010.13 ETN97963.1 - 8.2e-05 22.6 4.1 2.9 8.0 0.1 4.1 1 1 3 4 4 4 1 Protein of unknown function (DUF357) TPR_MalT PF17874.1 ETN97963.1 - 0.00011 21.8 0.0 0.00014 21.3 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region PPR PF01535.20 ETN97963.1 - 0.00028 20.9 9.6 2.3 8.7 0.1 4.5 5 0 0 5 5 4 1 PPR repeat Ten1_2 PF15490.6 ETN97963.1 - 0.00028 20.6 0.2 5.2 6.8 0.0 3.7 1 1 3 4 4 4 0 Telomere-capping, CST complex subunit MIT PF04212.18 ETN97963.1 - 0.0007 19.6 11.4 1.2 9.2 0.5 4.8 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain TLE_N PF03920.15 ETN97963.1 - 0.00087 19.4 2.4 13 5.9 0.2 4.1 1 1 2 4 4 4 0 Groucho/TLE N-terminal Q-rich domain ATP-synt_E_2 PF08112.11 ETN97963.1 - 0.0012 19.1 9.9 28 5.1 0.1 5.3 5 0 0 5 5 5 0 ATP synthase epsilon subunit TPR_5 PF12688.7 ETN97963.1 - 0.0014 18.8 0.1 3 8.1 0.0 3.8 2 1 2 4 4 4 1 Tetratrico peptide repeat HTH_Bact PF18768.1 ETN97963.1 - 0.0016 18.0 9.3 10 5.8 0.0 5.6 4 3 0 4 4 4 0 Helix-turn-helix bacterial domain SHNi-TPR PF10516.9 ETN97963.1 - 0.0017 17.8 1.3 1.1 8.7 0.0 4.2 5 0 0 5 5 5 1 SHNi-TPR DUF4810 PF16068.5 ETN97963.1 - 0.002 18.6 2.1 4.7 7.8 0.1 3.6 2 2 2 4 4 4 0 Domain of unknown function (DUF4810) Musclin PF11037.8 ETN97963.1 - 0.0028 17.6 0.0 45 4.0 0.0 4.3 4 1 1 5 5 5 0 Insulin-resistance promoting peptide in skeletal muscle Mob_Pre PF01076.19 ETN97963.1 - 0.0029 17.4 2.9 0.011 15.5 0.1 2.3 1 1 2 3 3 3 2 Plasmid recombination enzyme ILEI PF15711.5 ETN97963.1 - 0.0031 17.9 0.9 74 3.9 0.0 4.6 2 1 3 5 5 5 0 Interleukin-like EMT inducer TPR_19 PF14559.6 ETN97963.1 - 0.0038 17.7 0.9 0.55 10.8 0.1 3.0 1 1 3 4 4 4 1 Tetratricopeptide repeat DUF3450 PF11932.8 ETN97963.1 - 0.0054 16.1 3.8 11 5.3 0.1 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Sel1 PF08238.12 ETN97963.1 - 0.0058 17.3 7.8 32 5.4 0.0 5.5 5 2 0 5 5 5 0 Sel1 repeat Rota_NSP3 PF01665.16 ETN97963.1 - 0.011 14.9 6.2 0.43 9.6 0.2 3.4 1 1 3 4 4 4 0 Rotavirus non-structural protein NSP3 DUF386 PF04074.12 ETN97963.1 - 0.018 15.0 4.9 0.078 12.9 2.2 2.8 1 1 1 2 2 2 0 YhcH/YjgK/YiaL Fis1_TPR_C PF14853.6 ETN97963.1 - 0.023 14.8 11.5 1.4 9.0 0.2 4.1 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat mRNA_cap_C PF03919.15 ETN97963.1 - 0.025 15.2 0.8 1e+02 3.6 0.0 4.2 1 1 3 4 4 4 0 mRNA capping enzyme, C-terminal domain TBK1_CCD1 PF18394.1 ETN97963.1 - 0.026 14.1 0.0 1.1 8.7 0.0 2.2 2 0 0 2 2 2 0 TANK-binding kinase 1 coiled-coil domain 1 YecM PF06185.12 ETN97963.1 - 0.055 13.1 4.5 28 4.3 0.1 4.1 2 2 2 4 4 4 0 YecM protein UxuA PF03786.13 ETN97963.1 - 0.062 12.1 1.4 0.55 9.0 0.2 2.3 1 1 1 2 2 2 0 D-mannonate dehydratase (UxuA) bPH_3 PF14470.6 ETN97963.1 - 0.11 12.9 5.6 1.8 9.0 0.1 3.5 1 1 3 4 4 4 0 Bacterial PH domain Clathrin PF00637.20 ETN97963.1 - 0.12 12.2 5.9 8.2 6.3 0.0 3.5 2 1 2 4 4 4 0 Region in Clathrin and VPS NRBF2_MIT PF17169.4 ETN97963.1 - 0.2 11.9 5.3 37 4.6 0.0 4.2 2 2 2 5 5 5 0 MIT domain of nuclear receptor-binding factor 2 SPO22 PF08631.10 ETN97963.1 - 0.31 10.5 3.5 17 4.8 0.2 2.8 1 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like DUF627 PF04781.12 ETN97963.1 - 0.35 10.9 5.9 8.8 6.4 1.0 3.8 1 1 2 3 3 3 0 Protein of unknown function (DUF627) TPR_12 PF13424.6 ETN97964.1 - 4.6e-69 228.7 9.5 2.2e-22 79.1 0.1 5.2 1 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETN97964.1 - 1e-60 200.1 0.1 6.8e-11 41.7 0.0 7.0 6 1 1 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97964.1 - 1.7e-59 193.6 5.3 2.9e-09 36.3 0.0 7.1 6 1 1 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97964.1 - 2.2e-56 185.5 32.9 1.3e-10 40.6 1.4 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97964.1 - 3.1e-40 133.0 37.7 1.8e-08 33.9 1.9 7.2 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97964.1 - 1.5e-38 127.7 21.4 7.5e-08 31.9 0.5 7.1 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETN97964.1 - 3.4e-18 64.8 0.0 0.033 15.0 0.0 7.0 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN97964.1 - 2e-16 59.1 12.3 0.00035 20.8 0.1 7.5 7 3 1 8 8 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN97964.1 - 2.6e-15 55.8 35.8 0.01 15.5 0.5 9.1 7 3 2 9 9 9 6 TPR repeat TPR_16 PF13432.6 ETN97964.1 - 2.5e-14 53.6 0.0 0.0042 17.7 0.0 5.1 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETN97964.1 - 9.8e-14 51.0 3.8 0.069 13.8 0.0 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETN97964.1 - 1.8e-12 47.4 15.1 0.057 13.2 0.3 6.6 6 1 1 7 7 7 4 Domain of unknown function (DUF5113) SNAP PF14938.6 ETN97964.1 - 2.6e-10 40.2 4.7 0.00044 19.8 0.1 3.5 1 1 2 3 3 3 3 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 ETN97964.1 - 1e-09 38.2 0.0 2.5e-05 23.8 0.0 2.3 1 1 0 2 2 2 2 MalT-like TPR region MIT PF04212.18 ETN97964.1 - 1.3e-08 34.7 21.2 0.051 13.6 0.7 6.9 6 1 1 7 7 7 2 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETN97964.1 - 3.1e-08 34.0 0.9 2.1 8.9 0.1 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat PPR PF01535.20 ETN97964.1 - 4.4e-08 32.8 15.9 0.044 14.0 0.1 6.4 7 0 0 7 7 6 2 PPR repeat ANAPC3 PF12895.7 ETN97964.1 - 7e-08 32.6 10.8 0.16 12.2 0.1 5.0 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETN97964.1 - 2.2e-07 30.7 17.9 0.33 11.0 0.5 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat RPN7 PF10602.9 ETN97964.1 - 2.7e-07 30.5 13.6 0.02 14.6 0.3 5.1 1 1 3 5 5 5 2 26S proteasome subunit RPN7 DUF4810 PF16068.5 ETN97964.1 - 2.8e-07 31.0 4.0 1.5 9.4 0.0 5.4 5 1 0 6 6 5 1 Domain of unknown function (DUF4810) Mob_Pre PF01076.19 ETN97964.1 - 1e-06 28.7 5.4 0.015 15.1 0.0 3.1 1 1 2 3 3 3 3 Plasmid recombination enzyme SHNi-TPR PF10516.9 ETN97964.1 - 7e-06 25.4 5.4 4.2 6.9 0.0 6.1 7 0 0 7 7 6 0 SHNi-TPR DUF3856 PF12968.7 ETN97964.1 - 7.2e-06 26.1 1.3 1.1 9.3 0.0 4.4 1 1 2 3 3 3 1 Domain of Unknown Function (DUF3856) TPR_5 PF12688.7 ETN97964.1 - 2.2e-05 24.7 0.1 3.7 7.8 0.0 5.2 1 1 4 6 6 6 1 Tetratrico peptide repeat ATP-synt_E_2 PF08112.11 ETN97964.1 - 5.3e-05 23.4 21.2 0.63 10.4 0.2 7.3 6 1 0 7 7 7 1 ATP synthase epsilon subunit Sel1 PF08238.12 ETN97964.1 - 0.0004 21.0 14.5 5.9 7.7 0.4 7.7 7 3 0 7 7 7 0 Sel1 repeat Fis1_TPR_C PF14853.6 ETN97964.1 - 0.0009 19.3 18.0 5.7 7.1 0.0 6.0 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 ETN97964.1 - 0.00098 19.2 0.0 13 6.0 0.0 4.1 1 1 2 4 4 4 0 Tetratricopeptide repeat mRNA_cap_C PF03919.15 ETN97964.1 - 0.0014 19.2 2.3 8.6 7.0 0.0 4.9 2 1 1 4 4 4 0 mRNA capping enzyme, C-terminal domain Musclin PF11037.8 ETN97964.1 - 0.0016 18.3 0.0 11 5.9 0.0 4.6 6 1 1 7 7 5 0 Insulin-resistance promoting peptide in skeletal muscle DUF2225 PF09986.9 ETN97964.1 - 0.0023 17.7 10.1 0.38 10.4 0.5 3.0 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) HTH_Bact PF18768.1 ETN97964.1 - 0.003 17.1 15.1 16 5.2 0.0 7.1 6 1 0 6 6 6 0 Helix-turn-helix bacterial domain DUF3568 PF12092.8 ETN97964.1 - 0.0032 17.5 2.7 0.44 10.6 0.1 4.1 2 1 2 4 4 4 1 Protein of unknown function (DUF3568) ILEI PF15711.5 ETN97964.1 - 0.0055 17.1 1.8 55 4.3 0.0 5.4 4 3 3 7 7 6 0 Interleukin-like EMT inducer TPR_15 PF13429.6 ETN97964.1 - 0.015 14.6 0.1 13 4.9 0.0 4.2 3 2 1 4 4 4 0 Tetratricopeptide repeat SPO22 PF08631.10 ETN97964.1 - 0.016 14.7 5.4 0.82 9.1 0.0 3.6 2 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like bPH_3 PF14470.6 ETN97964.1 - 0.017 15.4 9.2 3.9 7.9 0.1 4.1 2 1 3 5 5 5 0 Bacterial PH domain DUF627 PF04781.12 ETN97964.1 - 0.02 14.9 10.1 1.5 8.9 0.3 4.8 2 2 3 5 5 5 0 Protein of unknown function (DUF627) Clathrin PF00637.20 ETN97964.1 - 0.024 14.5 9.9 5.6 6.8 0.0 5.2 3 2 2 6 6 5 0 Region in Clathrin and VPS OrfA PF17495.2 ETN97964.1 - 0.024 14.8 0.0 22 5.3 0.0 3.9 1 1 3 5 5 4 0 Vpr-like OrfA FATC PF02260.20 ETN97964.1 - 0.14 12.0 0.1 9.1 6.2 0.1 3.1 3 0 0 3 3 3 0 FATC domain Chordopox_A13L PF05961.11 ETN97964.1 - 0.15 12.3 12.3 14 6.0 0.1 5.4 4 2 2 6 6 5 0 Chordopoxvirus A13L protein NRBF2_MIT PF17169.4 ETN97964.1 - 0.19 12.0 3.2 64 3.9 0.0 4.3 5 0 0 5 5 4 0 MIT domain of nuclear receptor-binding factor 2 DUF2802 PF10975.8 ETN97964.1 - 0.26 11.4 1.0 51 4.1 0.0 4.0 4 1 1 5 5 5 0 Protein of unknown function (DUF2802) SLT PF01464.20 ETN97964.1 - 1 9.0 6.3 16 5.2 0.6 3.5 1 1 4 5 5 5 0 Transglycosylase SLT domain DUF3450 PF11932.8 ETN97964.1 - 2 7.7 9.8 24 4.1 0.1 4.2 1 1 4 5 5 5 0 Protein of unknown function (DUF3450) Phage_Gp23 PF10669.9 ETN97965.1 - 0.011 16.0 8.8 0.011 16.0 8.8 1.5 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Pur_ac_phosph_N PF16656.5 ETN97965.1 - 0.029 14.9 0.4 0.029 14.9 0.4 2.0 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Trypan_PARP PF05887.11 ETN97965.1 - 0.07 13.1 1.5 0.089 12.8 1.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GOLD_2 PF13897.6 ETN97965.1 - 0.2 12.2 3.3 0.32 11.5 3.3 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF3464 PF11947.8 ETN97965.1 - 0.99 9.1 5.0 1.5 8.6 5.0 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3915 PF13054.6 ETN97965.1 - 2.4 8.1 5.2 0.81 9.7 2.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 ETN97965.1 - 4.9 5.3 10.2 6.2 5.0 10.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family rve PF00665.26 ETN97966.1 - 4.3e-07 30.1 0.0 6.3e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 ETN97966.1 - 2.4e-05 24.0 0.0 4.4e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 ETN97966.1 - 0.0036 17.4 0.0 0.006 16.6 0.0 1.3 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain FAF PF11250.8 ETN97966.1 - 5.9 7.2 5.6 63 3.9 0.2 3.2 3 0 0 3 3 3 0 Fantastic Four meristem regulator BACK PF07707.15 ETN97967.1 - 9.5e-05 22.4 0.0 0.00014 21.9 0.0 1.4 1 0 0 1 1 1 1 BTB And C-terminal Kelch WD40 PF00400.32 ETN97968.1 - 2.6e-21 75.5 13.9 4.7e-07 30.4 0.7 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97968.1 - 5.7e-07 29.8 0.1 0.0015 18.8 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97968.1 - 5.1e-05 22.7 2.6 0.0041 16.5 0.3 2.2 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETN97968.1 - 0.00014 20.6 2.5 0.0045 15.7 0.6 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETN97968.1 - 0.028 14.0 3.6 0.091 12.3 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) SH3_13 PF18335.1 ETN97968.1 - 2 8.3 5.2 11 5.9 1.0 2.4 1 1 1 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain RyR PF02026.16 ETN97969.1 - 2.3e-05 24.5 0.2 8.9e-05 22.6 0.0 2.1 2 0 0 2 2 2 1 RyR domain Yos1 PF08571.10 ETN97970.1 - 0.0023 18.1 0.3 0.57 10.5 0.1 2.4 2 0 0 2 2 2 2 Yos1-like Salp15 PF12115.8 ETN97970.1 - 0.062 13.7 0.4 0.14 12.6 0.1 1.6 2 0 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Cas_Cas4 PF01930.17 ETN97970.1 - 0.13 12.3 3.2 0.32 11.1 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function DUF83 FYVE_2 PF02318.16 ETN97970.1 - 1 9.6 6.3 4.3 7.6 0.3 2.2 2 0 0 2 2 2 0 FYVE-type zinc finger PUB PF09409.10 ETN97971.1 - 0.04 13.8 0.6 0.11 12.5 0.6 1.8 1 1 0 1 1 1 0 PUB domain Kelch_2 PF07646.15 ETN97972.1 - 0.0024 17.8 0.3 3.5 7.7 0.2 2.7 1 1 1 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETN97972.1 - 0.062 13.6 0.1 0.39 11.1 0.0 2.2 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN97972.1 - 0.073 13.1 0.1 0.36 10.9 0.1 2.1 2 0 0 2 2 2 0 Kelch motif UDPG_MGDP_dh_C PF03720.15 ETN97973.1 - 0.053 13.9 0.2 0.18 12.2 0.1 1.8 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain Ground-like PF04155.18 ETN97975.1 - 0.031 14.9 2.2 0.053 14.2 2.2 1.4 1 1 0 1 1 1 0 Ground-like domain Cys_rich_VLP PF14194.6 ETN97975.1 - 0.054 13.6 4.5 0.11 12.7 0.6 2.5 3 0 0 3 3 3 0 Cysteine-rich VLP WD40 PF00400.32 ETN97976.1 - 5.1e-08 33.4 0.7 2.9e-07 31.1 1.2 1.9 2 1 0 2 2 2 1 WD domain, G-beta repeat Pentapeptide PF00805.22 ETN97978.1 - 1.4e-05 24.6 0.8 3.1e-05 23.5 0.1 2.0 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 ETN97978.1 - 0.0014 18.7 0.0 0.0024 18.0 0.0 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 ETN97978.1 - 0.0016 18.6 1.2 0.021 15.0 0.1 2.5 1 1 0 2 2 2 1 Pentapeptide repeats (9 copies) LZ3wCH PF18517.1 ETN97978.1 - 0.11 12.6 0.8 0.43 10.7 0.4 2.2 1 1 1 2 2 2 0 Leucine zipper with capping helix domain WD40 PF00400.32 ETN97979.1 - 0.0057 17.5 1.7 0.035 15.0 0.3 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat LIN52 PF10044.9 ETN97980.1 - 10 6.9 12.1 16 6.3 4.6 3.1 1 1 2 3 3 3 0 Retinal tissue protein DUF1033 PF06279.11 ETN97981.1 - 0.028 14.6 2.8 0.051 13.8 2.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1033) DUF4556 PF15094.6 ETN97981.1 - 0.035 13.3 0.4 0.043 13.0 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4556) PrgU PF09627.10 ETN97981.1 - 0.064 13.2 1.7 0.13 12.3 1.7 1.5 1 1 0 1 1 1 0 PrgU-like protein DUF3245 PF11595.8 ETN97981.1 - 0.081 13.4 4.2 0.12 12.9 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) PUB PF09409.10 ETN97982.1 - 0.0007 19.5 1.4 0.28 11.1 0.5 2.2 2 0 0 2 2 2 2 PUB domain WD40 PF00400.32 ETN97984.1 - 1.7e-44 148.9 15.3 2.9e-08 34.2 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97984.1 - 3e-17 62.7 0.2 0.00042 20.5 0.0 4.5 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN97984.1 - 5.1e-10 38.8 0.1 0.043 12.8 0.0 5.1 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN97984.1 - 3.1e-09 36.6 8.2 8.6e-05 22.0 0.5 3.3 2 1 2 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETN97984.1 - 8.1e-08 32.4 0.2 0.0034 17.3 0.1 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETN97984.1 - 1.2e-07 30.8 3.5 0.0078 14.9 0.1 4.1 1 1 2 3 3 3 2 Nucleoporin Nup120/160 NHL PF01436.21 ETN97984.1 - 9.3e-06 25.4 0.5 0.2 11.8 0.0 2.6 2 0 0 2 2 2 2 NHL repeat PALB2_WD40 PF16756.5 ETN97984.1 - 0.00016 20.7 0.3 2.4 7.0 0.1 3.3 1 1 2 3 3 3 2 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 ETN97984.1 - 0.00046 20.0 0.0 9.7 6.3 0.0 4.2 4 0 0 4 4 4 1 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETN97984.1 - 0.0005 18.7 0.0 0.0012 17.5 0.0 1.7 1 1 1 2 2 2 1 Cytochrome D1 heme domain VID27 PF08553.10 ETN97984.1 - 0.00074 18.7 0.1 0.13 11.3 0.1 2.4 1 1 1 2 2 2 2 VID27 C-terminal WD40-like domain Coatomer_WDAD PF04053.14 ETN97984.1 - 0.00093 18.3 1.2 0.0032 16.6 0.5 1.9 1 1 1 2 2 2 1 Coatomer WD associated region BBS2_Mid PF14783.6 ETN97984.1 - 0.0014 18.7 5.5 24 5.0 0.0 5.5 2 1 3 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 ETN97984.1 - 0.0018 17.6 0.2 0.76 9.0 0.0 2.8 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETN97984.1 - 0.0022 17.6 0.0 0.0033 17.0 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain DUF5474 PF17568.2 ETN97984.1 - 0.0029 17.6 0.6 0.65 10.1 0.0 3.6 2 1 1 4 4 4 1 Family of unknown function (DUF5474) PD40 PF07676.12 ETN97984.1 - 0.0041 17.0 0.6 8 6.5 0.0 3.9 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF1854 PF08909.11 ETN97984.1 - 0.012 15.5 0.7 0.075 12.8 0.1 2.3 1 1 1 3 3 3 0 Domain of unknown function (DUF1854) DUF4752 PF15944.5 ETN97986.1 - 0.15 12.1 1.9 0.18 11.8 1.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) YMF19 PF02326.15 ETN97986.1 - 0.33 11.8 4.9 0.45 11.3 4.9 1.2 1 0 0 1 1 1 0 Plant ATP synthase F0 WD40 PF00400.32 ETN97987.1 - 2.8e-62 205.2 23.2 2.1e-12 47.3 0.4 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97987.1 - 3e-31 107.6 2.4 1.3e-05 25.4 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97987.1 - 1.9e-14 53.7 1.2 0.00033 20.1 0.0 4.4 2 1 2 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETN97987.1 - 1.3e-11 44.1 1.0 0.0054 15.7 0.1 4.8 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETN97987.1 - 8.3e-09 34.9 0.9 3.2e-05 23.5 0.6 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) PQQ_2 PF13360.6 ETN97987.1 - 5.1e-07 29.5 0.7 0.00022 20.9 0.6 2.7 1 1 1 2 2 2 2 PQQ-like domain BBS2_Mid PF14783.6 ETN97987.1 - 1.2e-05 25.3 0.1 0.32 11.1 0.0 4.9 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Pentapeptide_4 PF13599.6 ETN97987.1 - 5.2e-05 23.3 1.4 0.00081 19.5 0.9 2.4 1 1 1 2 2 2 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETN97987.1 - 8.2e-05 22.4 13.1 6.6 6.8 0.0 6.6 7 0 0 7 7 6 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETN97987.1 - 0.00042 20.1 0.0 27 4.9 0.0 5.0 5 0 0 5 5 5 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETN97987.1 - 0.00073 18.2 0.7 0.043 12.4 0.1 2.7 1 1 1 3 3 3 1 Cytochrome D1 heme domain Frtz PF11768.8 ETN97987.1 - 0.00089 17.7 0.0 6.6 4.9 0.0 3.9 2 1 1 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz NYD-SP28_assoc PF14775.6 ETN97987.1 - 0.0025 17.9 0.1 17 5.6 0.0 4.9 5 0 0 5 5 5 0 Sperm tail C-terminal domain WXG100 PF06013.12 ETN97987.1 - 0.006 16.8 0.0 29 5.0 0.0 4.6 5 0 0 5 5 5 0 Proteins of 100 residues with WXG Pentapeptide_3 PF13576.6 ETN97987.1 - 0.0069 16.5 0.3 0.028 14.6 0.1 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Gmad1 PF10647.9 ETN97987.1 - 0.0071 16.1 0.4 0.39 10.4 0.1 3.7 1 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain ArlS_N PF18719.1 ETN97987.1 - 0.014 15.6 0.1 4.9 7.4 0.1 3.1 1 1 2 3 3 3 0 ArlS sensor domain DUF5570 PF17731.1 ETN97987.1 - 0.025 14.7 9.5 20 5.3 0.2 5.1 1 1 3 5 5 5 0 Family of unknown function (DUF5570) GspH PF12019.8 ETN97987.1 - 0.029 14.8 6.9 0.5 10.8 0.7 3.8 1 1 2 3 3 3 0 Type II transport protein GspH IKI3 PF04762.12 ETN97987.1 - 0.062 11.3 0.1 1.4 6.8 0.0 2.3 1 1 0 2 2 2 0 IKI3 family VID27 PF08553.10 ETN97987.1 - 0.062 12.3 0.0 0.34 9.9 0.0 2.2 1 1 1 3 3 3 0 VID27 C-terminal WD40-like domain DUF4072 PF13284.6 ETN97987.1 - 0.071 13.6 0.0 62 4.1 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4072) DUF3748 PF12566.8 ETN97987.1 - 0.097 12.6 0.2 31 4.5 0.0 3.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3748) DUF1513 PF07433.11 ETN97987.1 - 0.16 11.0 0.1 2.9 6.9 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETN97987.1 - 0.55 10.0 11.5 64 3.4 0.0 6.5 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETN97988.1 - 1.2e-67 222.1 21.0 1e-11 45.2 0.3 7.3 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN97988.1 - 5.2e-32 110.0 0.6 1.8e-05 25.0 0.0 5.7 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN97988.1 - 3.8e-15 56.0 0.2 0.00015 21.2 0.0 4.5 1 1 4 5 5 5 5 WD40-like domain PD40 PF07676.12 ETN97988.1 - 1.3e-10 40.9 7.9 12 6.0 0.0 7.8 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETN97988.1 - 2.4e-10 39.9 0.0 1.1 8.2 0.0 6.1 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETN97988.1 - 9e-09 34.8 0.9 3.3e-05 23.4 0.6 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) PQQ_2 PF13360.6 ETN97988.1 - 2.1e-06 27.5 0.6 4.5e-05 23.2 0.5 2.6 1 1 1 2 2 2 2 PQQ-like domain Cytochrom_D1 PF02239.16 ETN97988.1 - 4.6e-06 25.4 0.3 0.01 14.4 0.0 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETN97988.1 - 7.6e-05 22.8 1.9 0.0008 19.5 0.9 2.2 2 1 1 3 3 2 1 Pentapeptide repeats (9 copies) PQQ PF01011.21 ETN97988.1 - 0.00011 21.9 0.0 18 5.5 0.0 4.7 4 0 0 4 4 4 0 PQQ enzyme repeat Gmad1 PF10647.9 ETN97988.1 - 0.00018 21.4 0.1 0.22 11.3 0.0 3.9 2 1 2 4 4 4 1 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.9 ETN97988.1 - 0.00064 19.3 14.8 62 3.4 0.1 8.5 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Frtz PF11768.8 ETN97988.1 - 0.0019 16.6 0.0 11 4.1 0.0 3.8 1 1 3 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz Peptidase_C9 PF01707.16 ETN97988.1 - 0.0039 16.8 0.1 30 4.1 0.0 4.4 2 1 2 5 5 5 0 Peptidase family C9 WXG100 PF06013.12 ETN97988.1 - 0.006 16.8 0.0 30 5.0 0.0 4.2 5 0 0 5 5 4 0 Proteins of 100 residues with WXG Pentapeptide_3 PF13576.6 ETN97988.1 - 0.0074 16.4 0.3 0.028 14.6 0.3 2.0 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF1258 PF06869.12 ETN97988.1 - 0.018 14.6 0.0 0.57 9.6 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1258) GspH PF12019.8 ETN97988.1 - 0.023 15.1 6.0 2.4 8.6 0.2 3.8 1 1 2 3 3 3 0 Type II transport protein GspH ArlS_N PF18719.1 ETN97988.1 - 0.05 13.8 0.0 7 6.9 0.0 3.4 1 1 3 4 4 4 0 ArlS sensor domain Syntaxin_2 PF14523.6 ETN97990.1 - 0.007 16.7 11.6 0.0075 16.6 4.7 2.3 1 1 1 2 2 2 1 Syntaxin-like protein PRKG1_interact PF15898.5 ETN97990.1 - 0.048 14.6 9.0 0.066 14.1 9.0 1.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain BRE1 PF08647.11 ETN97990.1 - 3.9 7.6 16.7 0.38 10.8 8.9 2.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Transposase_22 PF02994.14 ETN97990.1 - 4.3 7.6 7.6 4.1 7.6 3.4 2.0 1 1 1 2 2 2 0 L1 transposable element RBD-like domain DUF5600 PF18150.1 ETN97991.1 - 1.1e-26 93.5 0.4 1.8e-26 92.8 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 ETN97991.1 - 5.5e-08 32.7 0.0 1.3e-07 31.5 0.0 1.6 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand YMF19 PF02326.15 ETN97991.1 - 0.16 12.7 1.8 0.34 11.7 0.4 2.1 2 0 0 2 2 2 0 Plant ATP synthase F0 TPR_12 PF13424.6 ETN97993.1 - 6.4e-10 39.2 0.2 1.2e-09 38.3 0.1 1.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN97993.1 - 1e-06 28.3 5.6 0.0026 17.5 2.5 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN97993.1 - 2.1e-06 27.5 4.1 0.00078 19.5 0.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat Pkinase PF00069.25 ETN97993.1 - 7.3e-06 25.5 1.3 1e-05 25.0 0.8 1.5 1 1 1 2 2 2 1 Protein kinase domain TPR_10 PF13374.6 ETN97993.1 - 4.5e-05 23.2 2.2 0.45 10.5 0.8 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN97993.1 - 4.5e-05 23.2 0.7 0.15 12.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN97993.1 - 0.0024 17.9 4.3 0.81 10.0 0.5 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETN97993.1 - 0.011 16.2 0.0 0.02 15.4 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Choline_kinase PF01633.20 ETN97993.1 - 0.012 15.2 0.7 0.023 14.3 0.7 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ETN97993.1 - 0.018 15.0 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETN97993.1 - 0.026 13.3 0.1 0.032 13.0 0.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase BRAP2 PF07576.12 ETN97993.1 - 0.026 14.7 0.3 1.7 8.9 0.2 2.4 2 0 0 2 2 2 0 BRCA1-associated protein 2 TPR_3 PF07720.12 ETN97993.1 - 0.034 14.1 0.5 2.2 8.3 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Atypical_Card PF18461.1 ETN97993.1 - 0.065 13.5 2.3 0.65 10.3 0.1 2.2 2 0 0 2 2 2 0 Atypical caspase recruitment domain eIF3_subunit PF08597.10 ETN97994.1 - 0.044 13.7 16.4 0.05 13.5 16.4 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit PEX11 PF05648.14 ETN97994.1 - 0.27 10.7 3.8 0.32 10.4 3.8 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) SR-25 PF10500.9 ETN97994.1 - 2.1 7.9 22.9 2.7 7.5 22.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 ETN97994.1 - 3.6 7.8 18.2 5.3 7.3 18.2 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Exonuc_VII_L PF02601.15 ETN97995.1 - 0.067 12.7 6.3 0.085 12.4 6.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FSA_C PF10479.9 ETN97995.1 - 0.36 8.9 15.2 0.48 8.5 15.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF1548 PF07579.11 ETN97996.1 - 0.049 14.0 2.4 0.046 14.1 1.0 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) Glyco_hydro_47 PF01532.20 ETN97997.1 - 1e-75 255.4 0.2 1.2e-75 255.1 0.2 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Gly_rich PF12810.7 ETN97998.1 - 9.7e-17 61.7 27.8 1.7e-16 60.9 27.8 1.3 1 0 0 1 1 1 1 Glycine rich protein WD40 PF00400.32 ETN98000.1 - 1e-09 38.8 13.3 0.0009 20.0 1.5 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98000.1 - 0.0018 18.6 0.1 0.45 10.8 0.1 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98000.1 - 0.048 12.3 0.1 6.9 5.2 0.0 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETN98001.1 - 9.3e-13 48.5 4.3 1.4e-05 25.7 0.2 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98001.1 - 0.0032 17.7 0.0 0.12 12.7 0.0 2.5 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98001.1 - 0.04 12.6 0.2 0.051 12.2 0.2 1.4 1 1 0 1 1 1 0 Nucleoporin Nup120/160 DUF2442 PF10387.9 ETN98001.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) Flavodoxin_3 PF12641.7 ETN98002.1 - 0.016 14.9 1.1 0.023 14.4 0.2 1.6 1 1 0 2 2 2 0 Flavodoxin domain DUF2749 PF10907.8 ETN98002.1 - 0.2 11.9 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2749) RTP1_C1 PF10363.9 ETN98003.1 - 0.00035 20.7 0.7 0.00077 19.6 0.1 1.8 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 FPL PF09758.9 ETN98003.1 - 0.0067 16.4 7.9 0.15 12.0 0.3 3.2 1 1 1 2 2 2 2 Uncharacterised conserved protein DNA_primase_lrg PF04104.14 ETN98003.1 - 0.073 12.5 0.9 0.17 11.2 0.1 1.8 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit Utp12 PF04003.12 ETN98003.1 - 0.073 13.4 1.0 7.9 6.8 0.1 2.9 2 2 0 2 2 2 0 Dip2/Utp12 Family DED PF01335.21 ETN98003.1 - 0.96 9.8 12.5 1.2 9.5 0.4 3.4 4 0 0 4 4 4 0 Death effector domain Cation_efflux PF01545.21 ETN98004.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Cation efflux family PUB PF09409.10 ETN98005.1 - 0.015 15.2 1.0 0.05 13.5 1.0 1.8 1 1 0 1 1 1 0 PUB domain SH3_5 PF08460.10 ETN98005.1 - 0.13 12.4 2.4 0.25 11.5 0.3 2.1 2 0 0 2 2 2 0 Bacterial SH3 domain CW_binding_1 PF01473.20 ETN98005.1 - 2 8.9 9.0 0.29 11.5 3.0 2.3 2 0 0 2 2 2 0 Putative cell wall binding repeat CDC45 PF02724.14 ETN98006.1 - 0.006 14.9 19.1 0.0057 15.0 19.1 1.0 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 ETN98006.1 - 0.037 14.2 14.8 0.038 14.1 14.8 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Apc15p PF05841.11 ETN98006.1 - 0.27 12.1 8.6 0.32 11.8 8.6 1.1 1 0 0 1 1 1 0 Apc15p protein Nop53 PF07767.11 ETN98006.1 - 0.28 10.5 18.4 0.33 10.3 18.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Connexin PF00029.19 ETN98006.1 - 0.3 10.8 2.0 0.33 10.7 2.0 1.1 1 0 0 1 1 1 0 Connexin Mpp10 PF04006.12 ETN98006.1 - 1.6 7.1 22.4 1.7 7.0 22.4 1.0 1 0 0 1 1 1 0 Mpp10 protein SDA1 PF05285.12 ETN98006.1 - 1.7 8.0 26.6 1.8 7.9 26.6 1.0 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 ETN98006.1 - 2 8.8 9.1 2.6 8.5 9.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 PTPRCAP PF15713.5 ETN98006.1 - 2.6 8.3 15.9 2.9 8.1 15.9 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 ETN98006.1 - 2.7 6.1 24.4 3.1 5.9 24.4 1.0 1 0 0 1 1 1 0 Nop14-like family Tim54 PF11711.8 ETN98006.1 - 5 5.8 10.3 5.7 5.6 10.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 ETN98006.1 - 6.1 5.5 13.1 6 5.5 13.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Zip PF02535.22 ETN98006.1 - 9.6 5.3 8.5 8.8 5.4 8.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETN98006.1 - 9.6 4.4 9.8 9.9 4.4 9.8 1.1 1 0 0 1 1 1 0 Menin Vfa1 PF08432.10 ETN98007.1 - 0.01 16.2 13.0 0.013 15.8 13.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 V_ATPase_I PF01496.19 ETN98007.1 - 0.049 11.6 2.9 0.058 11.3 2.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RNA_pol_Rpc4 PF05132.14 ETN98007.1 - 0.065 13.7 2.8 0.083 13.3 2.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RPN2_C PF18004.1 ETN98007.1 - 0.14 12.1 12.8 0.19 11.6 12.8 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ETN98007.1 - 0.16 10.7 4.0 0.19 10.4 4.0 1.1 1 0 0 1 1 1 0 Presenilin MDM10 PF12519.8 ETN98007.1 - 0.58 9.0 4.8 0.82 8.5 4.8 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TFB6 PF17110.5 ETN98007.1 - 8 6.2 9.6 12 5.5 9.6 1.4 1 1 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Motile_Sperm PF00635.26 ETN98009.1 - 0.049 13.5 0.1 0.066 13.1 0.1 1.2 1 0 0 1 1 1 0 MSP (Major sperm protein) domain Ribosomal_L27_C PF18471.1 ETN98011.1 - 0.024 14.1 2.3 0.04 13.4 2.3 1.5 1 1 0 1 1 1 0 Ribosomal L27 protein C-terminal domain KicB PF03882.14 ETN98011.1 - 0.057 13.6 1.3 0.57 10.4 0.3 2.5 1 1 2 3 3 3 0 MukF winged-helix domain Syja_N PF02383.18 ETN98011.1 - 0.18 11.1 1.9 0.49 9.6 1.0 2.1 1 1 1 2 2 2 0 SacI homology domain WD40 PF00400.32 ETN98012.1 - 6.1e-10 39.5 5.6 1e-05 26.1 0.7 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98012.1 - 0.00027 19.7 0.3 0.1 11.2 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Rtf2 PF04641.12 ETN98013.1 - 7.8e-08 32.0 0.1 2.4e-07 30.4 0.1 1.6 1 1 0 1 1 1 1 Rtf2 RING-finger zf-NOSIP PF15906.5 ETN98013.1 - 9.3e-07 28.9 0.1 1.9e-06 27.9 0.0 1.5 2 0 0 2 2 2 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETN98013.1 - 0.00024 20.8 0.1 0.13 12.0 0.0 2.4 2 0 0 2 2 2 2 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 ETN98013.1 - 0.0038 17.4 0.0 0.0094 16.1 0.0 1.6 1 1 0 1 1 1 1 U-box domain zf-TRAF PF02176.18 ETN98014.1 - 0.0057 17.3 2.2 0.0057 17.3 2.2 2.5 2 1 1 3 3 3 1 TRAF-type zinc finger Tubulin PF00091.25 ETN98015.1 - 0.012 15.8 0.2 0.021 15.0 0.2 1.4 1 0 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain CAP_C PF08603.11 ETN98016.1 - 1.1e-20 73.8 1.1 1.8e-20 73.1 1.1 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal CAP_N PF01213.19 ETN98016.1 - 1e-09 38.4 0.3 1.5e-09 37.8 0.3 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal TBCC PF07986.12 ETN98016.1 - 0.00012 21.8 3.9 0.00019 21.1 3.9 1.3 1 0 0 1 1 1 1 Tubulin binding cofactor C EF-hand_7 PF13499.6 ETN98017.1 - 1.4e-05 25.4 0.2 3.2e-05 24.3 0.2 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETN98017.1 - 8.7e-05 22.2 0.2 0.53 10.4 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETN98017.1 - 0.00047 19.5 0.2 1 9.1 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 ETN98017.1 - 0.035 14.0 0.6 0.21 11.5 0.0 2.4 3 0 0 3 3 3 0 EF hand EF-hand_8 PF13833.6 ETN98017.1 - 0.13 12.1 0.2 0.68 9.8 0.1 2.1 1 1 1 2 2 2 0 EF-hand domain pair SR-25 PF10500.9 ETN98018.1 - 0.29 10.7 9.0 0.37 10.4 9.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1940 PF09155.10 ETN98019.1 - 0.23 11.6 5.4 0.15 12.2 1.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1940) RGS-like PF09128.11 ETN98019.1 - 0.44 10.2 6.5 0.61 9.8 6.1 1.4 1 1 0 1 1 1 0 Regulator of G protein signalling-like domain Vps51 PF08700.11 ETN98019.1 - 0.7 10.0 6.5 11 6.1 0.8 2.7 1 1 2 3 3 3 0 Vps51/Vps67 Lipoprotein_2 PF00921.17 ETN98019.1 - 1.5 8.3 7.7 0.17 11.4 0.7 2.0 1 1 1 2 2 2 0 Borrelia lipoprotein PseudoU_synth_2 PF00849.22 ETN98020.1 - 0.00097 19.3 0.8 0.0011 19.0 0.1 1.5 2 0 0 2 2 2 1 RNA pseudouridylate synthase PseudoU_synth_2 PF00849.22 ETN98021.1 - 1.1e-08 35.4 0.0 2.6e-08 34.1 0.0 1.7 1 0 0 1 1 1 1 RNA pseudouridylate synthase Yuri_gagarin PF15934.5 ETN98021.1 - 0.063 13.1 0.4 0.15 11.9 0.1 1.7 2 0 0 2 2 2 0 Yuri gagarin Mod_r PF07200.13 ETN98021.1 - 0.077 13.1 1.3 0.19 11.9 1.3 1.6 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein CRAL_TRIO PF00650.20 ETN98024.1 - 0.072 12.8 0.6 0.12 12.0 0.4 1.5 1 1 0 1 1 1 0 CRAL/TRIO domain TPR_12 PF13424.6 ETN98025.1 - 7.7e-26 90.2 4.7 5.2e-11 42.7 0.2 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98025.1 - 4.6e-15 54.9 0.0 9.2e-05 22.2 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98025.1 - 1.3e-10 40.6 17.4 0.00036 20.5 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98025.1 - 9.1e-10 37.9 3.7 0.031 14.3 0.0 4.8 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98025.1 - 6.7e-08 32.0 20.6 3.4e-05 23.5 0.2 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98025.1 - 3.1e-06 26.9 15.2 0.09 12.9 0.2 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98025.1 - 0.0003 20.4 11.4 0.0047 16.6 0.7 4.4 5 1 1 6 6 6 2 TPR repeat Defb50 PF17546.2 ETN98025.1 - 0.044 13.7 0.1 0.25 11.3 0.1 2.2 2 0 0 2 2 2 0 Beta defensin 50 TPR_17 PF13431.6 ETN98025.1 - 0.056 13.8 1.5 8.8 7.0 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98025.1 - 0.079 13.6 3.0 4.2 8.2 0.2 3.7 4 1 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ETN98025.1 - 0.15 12.1 10.7 0.28 11.3 0.2 3.5 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Mob_Pre PF01076.19 ETN98025.1 - 7.2 6.4 9.1 20 4.9 0.2 2.2 1 1 1 2 2 2 0 Plasmid recombination enzyme Pkinase PF00069.25 ETN98026.1 - 4.8e-60 203.1 0.0 8.1e-60 202.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98026.1 - 5.7e-22 78.2 0.0 2e-21 76.4 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETN98026.1 - 8.3e-05 22.0 0.0 1.3 8.2 0.0 3.2 2 1 0 3 3 3 2 Kinase-like ORC_WH_C PF18137.1 ETN98026.1 - 0.23 11.5 1.5 0.46 10.6 1.1 1.7 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal WD40 PF00400.32 ETN98027.1 - 1.3e-39 133.5 22.9 2.4e-06 28.2 0.8 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98027.1 - 8.9e-13 48.4 2.0 0.0046 17.2 0.0 5.9 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98027.1 - 5.9e-12 45.0 6.5 0.011 14.4 0.0 5.6 2 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN98027.1 - 2.2e-05 23.9 4.3 0.062 12.6 0.2 4.6 3 1 2 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.11 ETN98027.1 - 0.0014 17.5 8.0 0.0069 15.2 4.0 3.5 1 1 1 2 2 2 1 Nup133 N terminal like Npun_R1517 PF18068.1 ETN98028.1 - 0.16 12.3 0.1 0.29 11.5 0.1 1.4 1 0 0 1 1 1 0 Npun R1517 Phage_Gp23 PF10669.9 ETN98030.1 - 3.4 8.0 10.9 0.29 11.5 6.2 1.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Csa1 PF06023.12 ETN98031.1 - 0.02 14.3 0.1 0.026 13.9 0.1 1.2 1 0 0 1 1 1 0 CRISPR-associated exonuclease Csa1 DUF2981 PF11200.8 ETN98032.1 - 1.3 8.7 6.6 1.7 8.3 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) HEAT PF02985.22 ETN98033.1 - 0.0031 17.6 0.0 0.57 10.6 0.0 2.7 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ETN98033.1 - 0.01 16.2 0.0 0.034 14.5 0.0 1.7 1 1 0 2 2 2 0 HEAT repeats Cnd1 PF12717.7 ETN98033.1 - 0.014 15.4 0.0 0.32 11.0 0.0 2.1 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Arm-DNA-bind_2 PF12167.8 ETN98033.1 - 0.15 12.0 0.0 1.1 9.2 0.0 2.0 2 0 0 2 2 2 0 Arm DNA-binding domain THDPS_N PF14790.6 ETN98036.1 - 0.024 14.5 0.0 0.034 14.0 0.0 1.2 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal DUF2207 PF09972.9 ETN98037.1 - 0.0018 17.1 8.0 0.0021 16.9 2.0 2.1 1 1 1 2 2 2 2 Predicted membrane protein (DUF2207) Sulf_transp PF04143.14 ETN98037.1 - 0.007 16.0 9.1 0.011 15.4 9.1 1.2 1 0 0 1 1 1 1 Sulphur transport Neurensin PF14927.6 ETN98037.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.6 1 0 0 1 1 1 0 Neurensin ETRAMP PF09716.10 ETN98037.1 - 0.035 14.2 3.9 0.88 9.7 0.1 2.7 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Thia_YuaJ PF09515.10 ETN98037.1 - 0.11 12.6 1.8 2.1 8.4 0.2 2.2 2 0 0 2 2 2 0 Thiamine transporter protein (Thia_YuaJ) Peptidase_M56 PF05569.11 ETN98037.1 - 3.9 6.6 6.9 0.31 10.2 0.8 2.1 3 0 0 3 3 3 0 BlaR1 peptidase M56 TFIIA PF03153.13 ETN98037.1 - 5.5 6.9 15.4 7.7 6.4 15.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit zf_C2H2_ZHX PF18387.1 ETN98038.1 - 0.047 13.3 1.4 1.6 8.5 0.3 2.3 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain MCM PF00493.23 ETN98041.1 - 1.2e-98 328.7 0.0 2.8e-98 327.5 0.0 1.6 2 0 0 2 2 2 1 MCM P-loop domain MCM_OB PF17207.3 ETN98041.1 - 8.9e-34 116.1 3.0 2.3e-33 114.7 3.0 1.7 1 1 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETN98041.1 - 5.8e-28 97.2 2.7 2.4e-27 95.2 1.5 2.4 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ETN98041.1 - 5.9e-08 32.3 0.1 2.4e-05 23.8 0.0 2.4 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI MCM_N PF14551.6 ETN98041.1 - 2e-07 31.5 0.7 9.7e-07 29.3 0.7 2.2 1 0 0 1 1 1 1 MCM N-terminal domain AAA_5 PF07728.14 ETN98041.1 - 2.9e-07 30.6 0.0 1e-06 28.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ETN98041.1 - 0.002 18.0 0.0 0.006 16.4 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETN98041.1 - 0.008 15.9 0.0 5.9 6.6 0.0 2.6 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_16 PF13191.6 ETN98041.1 - 0.01 16.2 0.0 0.044 14.2 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA PF00004.29 ETN98041.1 - 0.021 15.2 0.0 0.085 13.3 0.0 2.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_lid_2 PF17863.1 ETN98041.1 - 0.062 13.2 0.4 0.16 11.9 0.4 1.6 1 0 0 1 1 1 0 AAA lid domain Pex24p PF06398.11 ETN98041.1 - 2.1 7.2 5.3 4.8 6.1 0.1 3.0 3 0 0 3 3 3 0 Integral peroxisomal membrane peroxin RRM_1 PF00076.22 ETN98042.1 - 0.022 14.5 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_pol_Rpb2_5 PF04567.17 ETN98042.1 - 0.11 13.1 0.0 0.11 13.1 0.0 2.6 2 1 0 2 2 2 0 RNA polymerase Rpb2, domain 5 AAA PF00004.29 ETN98043.1 - 0.00024 21.5 0.3 0.067 13.6 0.0 4.0 4 1 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) EST1 PF10374.9 ETN98043.1 - 1.8 9.2 6.9 25 5.5 0.1 3.8 3 1 0 3 3 3 0 Telomerase activating protein Est1 Pkinase PF00069.25 ETN98046.1 - 2e-25 89.7 2.2 6.1e-11 42.2 1.0 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98046.1 - 2e-12 46.9 0.8 2.7e-05 23.6 0.5 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase APH PF01636.23 ETN98046.1 - 0.053 13.4 0.2 0.081 12.8 0.2 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF986 PF06173.12 ETN98046.1 - 0.66 10.0 8.0 0.23 11.6 3.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF986) Orf78 PF06024.12 ETN98047.1 - 0.0033 17.7 1.2 0.0033 17.7 1.2 2.0 1 1 1 2 2 2 1 Orf78 (ac78) CSG2 PF16965.5 ETN98047.1 - 0.059 12.3 2.8 0.069 12.1 2.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator SAM35 PF10806.8 ETN98047.1 - 1.7 8.9 8.7 0.74 10.1 2.5 2.3 2 1 0 2 2 2 0 SAM35, subunit of SAM coomplex DSPc PF00782.20 ETN98048.1 - 5.9e-22 77.9 0.1 7.4e-22 77.6 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETN98048.1 - 0.00041 20.0 0.0 0.00057 19.5 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETN98048.1 - 0.0068 16.7 0.0 0.0098 16.2 0.0 1.3 1 0 0 1 1 1 1 Rit1 DUSP-like domain AA_permease PF00324.21 ETN98049.1 - 1e-14 54.0 16.9 1.7e-14 53.3 16.9 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETN98049.1 - 0.00011 21.2 18.8 0.00016 20.7 18.8 1.2 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETN98050.1 - 5.7e-18 64.8 11.7 7.8e-16 57.7 7.2 2.1 2 0 0 2 2 2 2 Amino acid permease SLC12 PF03522.15 ETN98051.1 - 4.4e-17 62.2 0.2 5.5e-17 61.9 0.2 1.2 1 0 0 1 1 1 1 Solute carrier family 12 AA_permease PF00324.21 ETN98051.1 - 1.7e-07 30.3 1.4 2.1e-07 29.9 1.4 1.2 1 0 0 1 1 1 1 Amino acid permease Annexin PF00191.20 ETN98052.1 - 1.8e-06 27.9 0.0 2.2e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Annexin HI0933_like PF03486.14 ETN98053.1 - 0.091 11.4 0.3 0.092 11.4 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein zf-Sec23_Sec24 PF04810.15 ETN98055.1 - 0.038 14.0 0.1 0.12 12.4 0.1 1.9 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Peptidase_M50 PF02163.22 ETN98056.1 - 0.15 11.3 0.0 0.17 11.1 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M50 Bud13 PF09736.9 ETN98057.1 - 1.5 9.2 12.0 1.9 8.8 12.0 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex TolA_bind_tri PF16331.5 ETN98058.1 - 0.0021 18.1 2.4 0.0027 17.7 2.4 1.2 1 0 0 1 1 1 1 TolA binding protein trimerisation DUF3552 PF12072.8 ETN98058.1 - 0.026 13.9 7.1 0.034 13.6 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF3290 PF11694.8 ETN98058.1 - 0.097 12.6 0.1 0.15 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) DUF3584 PF12128.8 ETN98059.1 - 0.00048 17.8 3.5 0.00057 17.6 3.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) KASH_CCD PF14662.6 ETN98059.1 - 0.0054 16.6 5.4 0.0067 16.3 5.4 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 ETN98059.1 - 0.026 14.7 3.4 0.026 14.7 3.4 2.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper DUF913 PF06025.12 ETN98060.1 - 0.0033 16.4 0.5 0.016 14.2 0.2 1.7 1 1 1 2 2 2 2 Domain of Unknown Function (DUF913) DUF1884 PF08967.10 ETN98060.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1884) PPR PF01535.20 ETN98061.1 - 1.7e-05 24.7 0.3 0.094 13.0 0.0 2.7 2 0 0 2 2 2 2 PPR repeat PPR_2 PF13041.6 ETN98061.1 - 3.8e-05 23.8 0.2 0.0014 18.7 0.0 2.4 2 0 0 2 2 2 1 PPR repeat family WD40 PF00400.32 ETN98062.1 - 0.011 16.5 0.6 0.019 15.8 0.1 1.8 2 0 0 2 2 2 0 WD domain, G-beta repeat Nup160 PF11715.8 ETN98062.1 - 0.1 11.2 0.0 0.12 11.0 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 DEP PF00610.21 ETN98063.1 - 0.044 13.9 0.4 3.3 7.8 0.0 2.6 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SusF_SusE PF16411.5 ETN98063.1 - 0.069 13.7 0.7 0.25 11.9 0.1 1.9 1 1 1 2 2 2 0 Outer membrane protein SusF_SusE Pkinase PF00069.25 ETN98065.1 - 5.2e-12 45.7 5.0 9.4e-09 35.0 0.9 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98065.1 - 9.2e-07 28.4 2.9 5.6e-06 25.8 0.6 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase RhoGEF PF00621.20 ETN98066.1 - 2.7e-07 31.0 0.0 4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 RhoGEF domain SQS_PSY PF00494.19 ETN98067.1 - 6.3e-08 32.4 0.0 7.6e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Squalene/phytoene synthase HEAT_EZ PF13513.6 ETN98068.1 - 0.028 14.9 0.3 21 5.8 0.0 3.4 3 1 1 4 4 4 0 HEAT-like repeat HEAT PF02985.22 ETN98068.1 - 9.7 6.8 7.7 3.6 8.1 0.1 3.8 4 0 0 4 4 4 0 HEAT repeat DUF3440 PF11922.8 ETN98069.1 - 0.0034 17.1 0.4 0.0043 16.8 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3440) NACHT PF05729.12 ETN98070.1 - 0.002 18.1 0.6 0.0066 16.4 0.2 1.8 2 0 0 2 2 2 1 NACHT domain TEX19 PF15553.6 ETN98071.1 - 1.3 9.0 7.3 1.4 8.9 7.3 1.1 1 0 0 1 1 1 0 Testis-expressed protein 19 PTPRCAP PF15713.5 ETN98071.1 - 2.2 8.6 17.2 2.6 8.3 17.2 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CENP-I PF07778.11 ETN98071.1 - 2.3 6.8 9.5 2.3 6.8 9.5 1.0 1 0 0 1 1 1 0 Mis6 Tim54 PF11711.8 ETN98071.1 - 7.9 5.1 15.6 8.1 5.1 15.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RGS PF00615.19 ETN98073.1 - 0.0082 16.4 2.7 1.3 9.3 0.1 2.4 2 1 0 2 2 2 2 Regulator of G protein signaling domain PAT1 PF09770.9 ETN98074.1 - 1.8 6.8 28.9 2.1 6.5 28.9 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DHC_N2 PF08393.13 ETN98075.1 - 5.2e-14 52.2 3.8 1.2e-13 50.9 3.8 1.6 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 MULE PF10551.9 ETN98075.1 - 0.046 14.1 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 MULE transposase domain DUF4924 PF16271.5 ETN98076.1 - 0.0013 18.8 1.8 0.0015 18.5 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4924) TniB PF05621.11 ETN98076.1 - 0.049 13.1 0.3 0.055 12.9 0.3 1.1 1 0 0 1 1 1 0 Bacterial TniB protein WD40 PF00400.32 ETN98079.1 - 4.7e-52 172.8 20.6 3.4e-09 37.2 0.3 6.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98079.1 - 9.7e-15 54.7 6.6 0.00028 21.1 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98079.1 - 7.1e-12 44.9 4.1 0.21 10.5 0.0 5.7 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN98079.1 - 7.8e-08 32.0 0.3 0.0022 17.4 0.1 3.5 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETN98079.1 - 2.3e-07 29.8 8.9 0.92 8.1 0.0 5.8 1 1 5 6 6 6 4 Nucleoporin Nup120/160 HARP PF07443.13 ETN98079.1 - 0.00027 20.5 0.4 3.4 7.4 0.0 4.0 4 0 0 4 4 4 2 HepA-related protein (HARP) DUF5570 PF17731.1 ETN98079.1 - 0.0029 17.7 4.0 1.2 9.3 0.2 4.3 1 1 5 6 6 6 1 Family of unknown function (DUF5570) PALB2_WD40 PF16756.5 ETN98079.1 - 0.0033 16.4 6.4 0.0073 15.3 0.4 3.5 1 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETN98079.1 - 0.0033 17.3 1.9 5.6 7.0 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF1258 PF06869.12 ETN98079.1 - 0.0041 16.6 0.3 0.55 9.7 0.2 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1258) Cytochrom_D1 PF02239.16 ETN98079.1 - 0.0052 15.4 1.0 1 7.8 0.1 2.7 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETN98079.1 - 0.027 13.2 3.3 0.38 9.4 0.3 3.4 1 1 2 3 3 3 0 Nup133 N terminal like Utp8 PF10395.9 ETN98079.1 - 0.086 11.3 0.1 0.14 10.6 0.1 1.5 1 0 0 1 1 1 0 Utp8 family Methyltransf_12 PF08242.12 ETN98080.1 - 0.011 16.4 0.2 0.018 15.8 0.2 1.3 1 0 0 1 1 1 0 Methyltransferase domain Glyoxalase_6 PF18029.1 ETN98080.1 - 0.2 12.4 0.1 0.3 11.9 0.1 1.4 1 1 0 1 1 1 0 Glyoxalase-like domain Kelch_1 PF01344.25 ETN98081.1 - 7.4e-08 31.9 3.7 1.2e-06 27.9 0.4 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETN98081.1 - 4.5e-07 29.9 3.7 0.0076 16.5 0.3 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETN98081.1 - 5.5e-05 23.0 3.9 0.11 12.6 1.4 4.9 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 ETN98081.1 - 6.9e-05 22.7 3.9 0.0055 16.6 0.3 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETN98081.1 - 0.0044 17.0 1.2 0.043 13.8 0.1 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETN98081.1 - 0.006 16.9 0.6 0.074 13.4 0.1 3.0 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF3819 PF12842.7 ETN98082.1 - 0.0081 16.1 0.3 0.0085 16.0 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) Spore_YunB PF09560.10 ETN98087.1 - 0.11 12.5 0.1 0.57 10.2 0.0 1.8 2 0 0 2 2 2 0 Sporulation protein YunB (Spo_YunB) MethyltransfD12 PF02086.15 ETN98089.1 - 4.3e-16 59.4 1.0 5.1e-16 59.1 0.1 1.5 2 0 0 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase HSDR_N_2 PF13588.6 ETN98089.1 - 0.0022 18.0 1.3 0.047 13.7 0.2 2.5 2 1 1 3 3 3 2 Type I restriction enzyme R protein N terminus (HSDR_N) DUF515 PF04415.12 ETN98091.1 - 0.061 11.7 1.3 0.069 11.5 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF1104 PF06518.11 ETN98091.1 - 0.067 13.6 1.8 0.094 13.1 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) DUF5487 PF17589.2 ETN98091.1 - 0.074 13.3 0.2 0.16 12.2 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5487) zf-TRAF PF02176.18 ETN98092.1 - 6.5e-06 26.7 2.4 1.3e-05 25.8 2.4 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger Fzo_mitofusin PF04799.13 ETN98092.1 - 0.0016 18.0 4.4 0.0016 18.0 4.4 1.7 1 1 1 2 2 2 2 fzo-like conserved region zf-TRAF_2 PF15965.5 ETN98092.1 - 0.061 13.8 0.7 0.12 12.9 0.7 1.5 1 0 0 1 1 1 0 TRAF-like zinc-finger DUF1192 PF06698.11 ETN98092.1 - 0.065 13.3 1.2 1.8 8.7 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) YabA PF06156.13 ETN98092.1 - 1.4 9.6 12.1 3.5 8.3 12.0 1.8 1 1 0 1 1 1 0 Initiation control protein YabA Cep57_CLD_2 PF14197.6 ETN98092.1 - 6.3 7.0 13.8 9.8 6.4 8.7 3.0 3 1 0 3 3 3 0 Centrosome localisation domain of PPC89 HemN_C PF06969.16 ETN98093.1 - 0.0048 16.9 0.1 3.5 7.8 0.0 2.2 2 0 0 2 2 2 2 HemN C-terminal domain RasGEF PF00617.19 ETN98093.1 - 0.013 15.8 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 RasGEF domain ubiquitin PF00240.23 ETN98094.1 - 2.5e-10 40.0 0.0 4.7e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETN98094.1 - 0.012 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Lge1 PF11488.8 ETN98095.1 - 0.042 14.0 1.0 0.042 14.0 1.0 1.7 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 AF-4 PF05110.13 ETN98096.1 - 0.19 9.8 16.3 0.24 9.4 16.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RP-C_C PF11800.8 ETN98096.1 - 1.4 8.9 4.7 2 8.4 4.7 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Secretin_N_2 PF07655.13 ETN98096.1 - 6 7.5 21.5 15 6.2 21.5 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain Sp38 PF07354.12 ETN98097.1 - 0.033 13.6 0.2 0.64 9.4 0.2 2.0 1 1 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) RVT_1 PF00078.27 ETN98098.1 - 5.9e-05 22.7 0.1 6.4e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 ETN98101.1 - 2.6e-11 43.9 0.2 4.9e-06 27.2 0.0 3.1 2 2 1 3 3 3 2 WD domain, G-beta repeat DUF3954 PF13128.6 ETN98101.1 - 0.018 14.8 0.2 6.7 6.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3954) Nup160 PF11715.8 ETN98101.1 - 0.027 13.1 1.4 0.41 9.2 0.2 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PITH PF06201.13 ETN98102.1 - 0.12 12.5 1.6 0.18 12.0 1.6 1.3 1 1 0 1 1 1 0 PITH domain Filament PF00038.21 ETN98104.1 - 4.1 6.9 173.4 0.022 14.3 8.1 8.9 2 1 5 8 8 8 0 Intermediate filament protein SCAB_CC PF16712.5 ETN98105.1 - 0.00081 19.3 1.9 0.00081 19.3 1.9 1.6 1 1 0 1 1 1 1 Coiled-coil regions of plant-specific actin-binding protein zf-C4H2 PF10146.9 ETN98105.1 - 0.0078 16.5 2.3 0.0078 16.5 2.3 1.5 1 1 0 1 1 1 1 Zinc finger-containing protein PRKG1_interact PF15898.5 ETN98105.1 - 0.043 14.7 2.1 0.043 14.7 2.1 2.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF1216 PF06746.11 ETN98105.1 - 0.098 12.7 0.7 0.21 11.6 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1216) SNARE PF05739.19 ETN98106.1 - 9.9e-06 25.5 2.0 9.9e-06 25.5 2.0 1.9 2 0 0 2 2 2 1 SNARE domain Use1 PF09753.9 ETN98106.1 - 0.00025 20.9 8.4 0.00038 20.3 8.4 1.3 1 0 0 1 1 1 1 Membrane fusion protein Use1 DUF1359 PF07097.11 ETN98106.1 - 0.0092 16.2 2.3 0.021 15.0 2.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1359) Med15_fungi PF05397.12 ETN98106.1 - 0.021 15.1 3.1 0.059 13.6 0.2 2.7 2 1 0 2 2 2 0 Mediator complex subunit 15 Prominin PF05478.11 ETN98106.1 - 0.066 11.2 11.4 0.0027 15.8 3.6 1.9 1 1 1 2 2 2 0 Prominin Sec20 PF03908.13 ETN98106.1 - 2.4 8.1 8.8 8.4 6.4 0.3 3.0 2 2 1 3 3 3 0 Sec20 Laminin_II PF06009.12 ETN98106.1 - 4.5 7.3 9.9 0.7 9.9 1.8 2.4 2 0 0 2 2 2 0 Laminin Domain II Noelin-1 PF12308.8 ETN98106.1 - 5.7 7.0 9.1 0.47 10.5 1.9 2.5 2 2 0 2 2 2 0 Neurogenesis glycoprotein TMPIT PF07851.13 ETN98106.1 - 6.1 6.0 13.1 3.6 6.7 1.9 2.1 2 0 0 2 2 2 0 TMPIT-like protein PH PF00169.29 ETN98107.1 - 0.00049 20.6 3.9 0.0029 18.1 0.2 2.9 3 0 0 3 3 3 2 PH domain Annexin PF00191.20 ETN98109.1 - 3.4e-12 46.3 0.5 2.1e-07 30.9 0.1 2.6 2 0 0 2 2 2 2 Annexin Uds1 PF15456.6 ETN98109.1 - 0.033 14.4 4.0 0.064 13.4 0.3 2.1 2 0 0 2 2 2 0 Up-regulated During Septation GA PF01468.17 ETN98109.1 - 0.11 12.8 0.5 0.11 12.8 0.5 2.2 2 0 0 2 2 2 0 GA module Ground-like PF04155.18 ETN98109.1 - 5.5 7.7 6.8 3.3 8.4 0.9 2.8 2 2 1 3 3 3 0 Ground-like domain Gpi16 PF04113.14 ETN98111.1 - 6.5e-09 34.8 0.0 7.3e-09 34.6 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component GFA PF04828.14 ETN98112.1 - 0.011 16.1 0.5 0.02 15.3 0.3 1.5 1 1 0 1 1 1 0 Glutathione-dependent formaldehyde-activating enzyme FapA PF03961.13 ETN98114.1 - 0.0086 14.7 7.8 0.0091 14.7 7.8 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A Allexi_40kDa PF05549.11 ETN98114.1 - 0.13 11.7 1.1 0.14 11.6 1.1 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein Laminin_II PF06009.12 ETN98114.1 - 0.19 11.8 2.5 3.2 7.8 0.3 2.2 2 0 0 2 2 2 0 Laminin Domain II SOGA PF11365.8 ETN98114.1 - 0.39 11.9 7.8 0.66 11.1 7.8 1.3 1 0 0 1 1 1 0 Protein SOGA SLATT_1 PF18181.1 ETN98115.1 - 0.35 10.8 1.5 32 4.5 0.0 2.9 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 CAC1F_C PF16885.5 ETN98116.1 - 9.8 5.7 16.0 13 5.3 16.0 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term RelA_SpoT PF04607.17 ETN98118.1 - 0.0099 16.2 0.1 0.011 15.9 0.1 1.1 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins CobT_C PF11775.8 ETN98119.1 - 3.8e-52 177.1 0.1 7.3e-40 136.9 0.0 2.1 1 1 1 2 2 2 2 Cobalamin biosynthesis protein CobT VWA domain VWA PF00092.28 ETN98119.1 - 0.002 18.4 0.0 0.6 10.3 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Phage_min_cap2 PF06152.11 ETN98120.1 - 0.033 13.1 0.7 0.038 12.9 0.7 1.1 1 0 0 1 1 1 0 Phage minor capsid protein 2 MMR_HSR1 PF01926.23 ETN98121.1 - 3.5e-06 27.1 0.1 3e-05 24.1 0.1 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETN98121.1 - 2.9e-05 24.1 0.9 0.00046 20.1 0.9 2.2 1 1 0 1 1 1 1 RsgA GTPase Dynamin_N PF00350.23 ETN98121.1 - 0.00011 22.3 0.5 0.091 12.8 0.0 2.1 1 1 1 2 2 2 2 Dynamin family ABC_tran PF00005.27 ETN98121.1 - 0.00019 22.0 0.1 0.00021 21.8 0.1 1.2 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ETN98121.1 - 0.0028 17.3 0.2 0.005 16.5 0.2 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 ETN98121.1 - 0.0041 16.6 0.1 0.0073 15.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region Septin PF00735.18 ETN98121.1 - 0.0047 16.2 0.1 0.0066 15.8 0.1 1.2 1 0 0 1 1 1 1 Septin T2SSE PF00437.20 ETN98121.1 - 0.0067 15.5 0.2 0.0099 15.0 0.2 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein SRP54 PF00448.22 ETN98121.1 - 0.0094 15.6 0.2 0.024 14.3 0.2 1.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AAA_28 PF13521.6 ETN98121.1 - 0.012 15.9 0.6 0.015 15.6 0.6 1.4 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ETN98121.1 - 0.014 15.7 0.1 0.016 15.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETN98121.1 - 0.025 15.1 0.2 0.025 15.1 0.2 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETN98121.1 - 0.029 14.7 0.2 0.058 13.8 0.2 1.5 1 1 0 1 1 1 0 RNA helicase DUF815 PF05673.13 ETN98121.1 - 0.041 13.0 0.3 0.053 12.7 0.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF815) Zeta_toxin PF06414.12 ETN98121.1 - 0.046 13.0 0.1 0.079 12.2 0.1 1.3 1 1 0 1 1 1 0 Zeta toxin PhoH PF02562.16 ETN98121.1 - 0.048 13.1 0.3 0.083 12.3 0.2 1.4 1 1 0 1 1 1 0 PhoH-like protein MCM PF00493.23 ETN98121.1 - 0.058 12.5 0.1 0.097 11.8 0.1 1.4 1 1 0 1 1 1 0 MCM P-loop domain ABC_ATPase PF09818.9 ETN98121.1 - 0.063 12.1 0.1 0.065 12.0 0.1 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class Ploopntkinase3 PF18751.1 ETN98121.1 - 0.068 13.1 0.0 0.088 12.7 0.0 1.1 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 PduV-EutP PF10662.9 ETN98121.1 - 0.073 12.8 0.7 0.22 11.3 0.2 1.9 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 ETN98121.1 - 0.074 12.8 0.2 0.16 11.7 0.1 1.5 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA PF00004.29 ETN98121.1 - 0.081 13.4 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETN98121.1 - 0.1 12.9 0.2 0.13 12.5 0.2 1.3 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETN98121.1 - 0.13 12.8 0.3 0.17 12.5 0.3 1.4 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETN98121.1 - 0.13 12.0 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_10 PF12846.7 ETN98121.1 - 0.13 11.1 0.1 0.13 11.1 0.1 1.1 1 0 0 1 1 1 0 AAA-like domain AAA_25 PF13481.6 ETN98121.1 - 0.16 11.5 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETN98121.1 - 0.19 12.1 0.0 0.21 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ETN98121.1 - 0.2 11.7 0.2 0.28 11.2 0.2 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DAP3 PF10236.9 ETN98121.1 - 0.24 10.6 0.4 0.32 10.1 0.4 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DUF2251 PF10008.9 ETN98125.1 - 0.071 13.2 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) Macoilin PF09726.9 ETN98130.1 - 6.5 5.2 8.7 7.3 5.0 8.7 1.1 1 0 0 1 1 1 0 Macoilin family 7tm_7 PF08395.12 ETN98131.1 - 0.4 9.8 4.4 0.45 9.7 4.4 1.0 1 0 0 1 1 1 0 7tm Chemosensory receptor Kelch_2 PF07646.15 ETN98132.1 - 0.00062 19.6 0.2 0.0017 18.3 0.2 1.8 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 ETN98132.1 - 0.00078 19.7 1.6 0.0047 17.2 0.2 2.4 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN98132.1 - 0.0052 16.8 0.0 0.012 15.6 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98132.1 - 0.09 12.4 0.3 0.3 10.7 0.1 2.0 2 0 0 2 2 2 0 Kelch motif RRM_1 PF00076.22 ETN98133.1 - 0.00043 20.1 0.0 0.00078 19.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETN98133.1 - 0.08 13.1 0.0 0.16 12.1 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 ETN98133.1 - 0.15 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH_2 PF14608.6 ETN98133.1 - 2.2 8.9 6.0 1.2 9.7 2.0 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger RRM_1 PF00076.22 ETN98134.1 - 0.00042 20.1 0.0 0.00071 19.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETN98134.1 - 0.069 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif Nup35_RRM_2 PF14605.6 ETN98134.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif zf-CCCH_2 PF14608.6 ETN98134.1 - 2 9.0 6.0 1.1 9.8 2.0 2.5 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger VWA_2 PF13519.6 ETN98136.1 - 0.0046 17.6 0.0 0.0086 16.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ETN98136.1 - 0.013 14.9 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein VWA PF00092.28 ETN98136.1 - 0.048 13.9 0.0 0.066 13.5 0.0 1.3 1 1 0 1 1 1 0 von Willebrand factor type A domain Thioredoxin_6 PF13848.6 ETN98136.1 - 0.074 13.0 0.2 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin-like domain PH_2 PF08458.10 ETN98137.1 - 0.00079 19.7 0.0 0.0012 19.2 0.0 1.4 1 0 0 1 1 1 1 Plant pleckstrin homology-like region PH_13 PF16652.5 ETN98137.1 - 0.008 16.0 0.0 0.0091 15.8 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_16 PF17838.1 ETN98137.1 - 0.049 13.5 0.0 0.091 12.6 0.0 1.4 1 0 0 1 1 1 0 PH domain PH_11 PF15413.6 ETN98137.1 - 0.098 13.1 0.1 0.18 12.3 0.1 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain UQ_con PF00179.26 ETN98138.1 - 1.1e-05 25.1 0.5 1.2e-05 25.0 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETN98138.1 - 0.059 13.7 0.3 0.077 13.3 0.3 1.3 1 0 0 1 1 1 0 RWD domain MAD PF05557.13 ETN98139.1 - 0.0031 16.0 35.7 0.0047 15.4 35.7 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein HOOK PF05622.12 ETN98139.1 - 0.0045 15.2 34.8 0.022 12.9 34.8 1.9 1 1 0 1 1 1 1 HOOK protein CALCOCO1 PF07888.11 ETN98139.1 - 0.043 12.7 29.3 0.066 12.1 29.3 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4019 PF13211.6 ETN98139.1 - 1.7 9.0 7.2 1.2 9.5 4.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4019) FlaC_arch PF05377.11 ETN98139.1 - 6.6 7.2 12.3 9.3 6.7 2.7 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF5320 PF17253.2 ETN98139.1 - 8.9 7.5 0.0 8.9 7.5 0.0 4.2 2 1 2 4 4 4 0 Family of unknown function (DUF5320) DUF2207 PF09972.9 ETN98139.1 - 9.8 4.8 13.4 0.13 11.0 4.2 2.1 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Cauli_AT PF03233.13 ETN98140.1 - 0.042 13.8 0.2 0.042 13.8 0.2 2.4 3 0 0 3 3 3 0 Aphid transmission protein zf-C4_Topoisom PF01396.19 ETN98140.1 - 0.063 13.1 0.5 5 7.0 0.1 2.9 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger Cullin_Nedd8 PF10557.9 ETN98141.1 - 0.0021 18.0 2.0 0.0021 18.0 2.0 2.5 2 0 0 2 2 2 1 Cullin protein neddylation domain Pterin_bind PF00809.22 ETN98141.1 - 0.012 15.3 1.7 0.018 14.7 1.6 1.3 1 1 0 1 1 1 0 Pterin binding enzyme CBM_4_9 PF02018.17 ETN98141.1 - 0.042 14.1 0.8 0.054 13.8 0.8 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain Vac_Fusion PF02346.16 ETN98141.1 - 0.047 13.3 6.3 0.11 12.1 0.8 2.5 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DUF1664 PF07889.12 ETN98141.1 - 0.054 13.5 12.7 0.35 10.9 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) F_actin_bind PF08919.10 ETN98141.1 - 0.067 13.3 4.9 0.12 12.5 4.9 1.4 1 0 0 1 1 1 0 F-actin binding G-gamma PF00631.22 ETN98141.1 - 0.07 13.1 1.2 0.18 11.8 0.5 2.1 2 0 0 2 2 2 0 GGL domain OmpH PF03938.14 ETN98141.1 - 0.074 13.4 15.4 6.2 7.2 15.6 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) PI3Ka PF00613.20 ETN98141.1 - 0.15 11.5 7.5 0.66 9.3 1.6 2.4 1 1 1 2 2 2 0 Phosphoinositide 3-kinase family, accessory domain (PIK domain) EF-hand_7 PF13499.6 ETN98141.1 - 0.16 12.4 1.9 2 8.9 1.9 2.6 1 1 0 1 1 1 0 EF-hand domain pair V-ATPase_G_2 PF16999.5 ETN98141.1 - 0.19 12.2 3.3 2.5 8.6 0.2 2.2 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit DLP_helical PF18709.1 ETN98141.1 - 0.34 10.1 12.3 0.76 8.9 12.3 1.5 1 1 0 1 1 1 0 Dynamin-like helical domain PIN_2 PF10130.9 ETN98141.1 - 0.77 10.0 8.3 0.78 10.0 5.7 2.0 1 1 1 2 2 2 0 PIN domain Baculo_PEP_C PF04513.12 ETN98141.1 - 0.83 9.7 9.9 0.53 10.3 1.1 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HEPN_Swt1 PF18731.1 ETN98141.1 - 0.83 10.0 5.6 4.3 7.7 0.7 2.3 1 1 1 2 2 2 0 Swt1-like HEPN MCPsignal PF00015.21 ETN98141.1 - 1.1 9.1 7.9 7.7 6.3 0.5 2.2 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain GP3_package PF16677.5 ETN98141.1 - 1.1 9.4 4.7 18 5.5 0.1 2.4 1 1 0 2 2 2 0 DNA-packaging protein gp3 DpnI_C PF17726.1 ETN98141.1 - 1.6 8.9 0.0 1.6 8.9 0.0 3.7 2 1 1 3 3 3 0 Dam-replacing HTH domain LMBR1 PF04791.16 ETN98141.1 - 6.1 5.6 11.5 6.9 5.4 11.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 ETN98144.1 - 6e-43 144.0 10.8 1.9e-10 41.2 0.0 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98144.1 - 1.1e-17 64.1 0.3 0.00043 20.5 0.0 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98144.1 - 8.1e-13 48.0 2.0 0.03 13.3 0.0 5.3 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETN98144.1 - 5.7e-09 36.1 0.2 0.0057 16.6 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETN98144.1 - 9.6e-06 24.5 0.2 0.11 11.2 0.0 3.5 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETN98144.1 - 1.5e-05 23.7 0.0 0.0073 14.9 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETN98144.1 - 4.1e-05 23.1 0.5 0.19 11.0 0.0 2.5 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 ETN98144.1 - 0.0022 17.9 3.4 13 5.9 0.1 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat nos_propeller PF18764.1 ETN98144.1 - 0.016 15.1 0.1 5.7 6.9 0.0 3.7 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat Proteasome_A_N PF10584.9 ETN98144.1 - 0.064 12.9 5.2 2.8 7.7 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETN98146.1 - 0.0017 19.1 0.3 0.015 16.1 0.3 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat TIP49_C PF17856.1 ETN98146.1 - 0.093 12.9 0.3 0.39 10.9 0.1 1.9 2 0 0 2 2 2 0 TIP49 AAA-lid domain NACHT PF05729.12 ETN98147.1 - 2.2e-08 34.2 0.0 3.4e-08 33.6 0.0 1.3 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETN98147.1 - 0.1 12.5 0.0 0.27 11.2 0.0 1.8 1 1 0 1 1 1 0 STI1 domain Sulfate_transp PF00916.20 ETN98148.1 - 8.5e-23 80.7 1.1 1.2e-22 80.2 1.1 1.2 1 0 0 1 1 1 1 Sulfate permease family TPR_12 PF13424.6 ETN98150.1 - 2.5e-39 133.4 2.1 5.1e-18 65.1 0.2 2.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98150.1 - 2.8e-22 77.9 0.0 1.8e-10 40.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98150.1 - 4.9e-18 64.1 9.9 2.3e-09 36.7 0.6 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98150.1 - 2.6e-17 61.5 0.1 7.1e-09 35.1 0.1 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98150.1 - 3.7e-17 61.0 8.5 1.6e-08 34.1 1.3 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98150.1 - 5.5e-14 51.1 5.2 1.4e-06 28.0 0.2 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98150.1 - 2.8e-09 36.7 1.7 0.00069 19.8 0.1 3.0 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98150.1 - 1.8e-07 31.7 0.0 0.016 15.8 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETN98150.1 - 1.2e-05 25.1 1.2 0.074 13.1 0.3 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98150.1 - 2.7e-05 24.5 0.0 0.15 12.7 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98150.1 - 0.00016 22.2 0.0 0.81 10.7 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF4810 PF16068.5 ETN98150.1 - 0.00044 20.7 0.3 1.1 9.8 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF4810) RPN7 PF10602.9 ETN98150.1 - 0.0005 19.8 0.1 0.00064 19.5 0.1 1.1 1 0 0 1 1 1 1 26S proteasome subunit RPN7 DUF5113 PF17140.4 ETN98150.1 - 0.00085 19.2 1.9 0.29 10.9 0.3 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETN98150.1 - 0.00094 18.8 11.9 1.2 8.9 1.7 4.1 3 1 1 4 4 4 1 TPR repeat TPR_MalT PF17874.1 ETN98150.1 - 0.0011 18.4 0.0 0.0013 18.2 0.0 1.0 1 0 0 1 1 1 1 MalT-like TPR region HTH_Bact PF18768.1 ETN98150.1 - 0.0011 18.4 1.0 1.7 8.2 0.1 3.3 3 1 1 4 4 4 2 Helix-turn-helix bacterial domain MIT PF04212.18 ETN98150.1 - 0.0016 18.5 3.4 0.04 14.0 0.7 2.2 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETN98150.1 - 0.0026 17.9 1.5 0.6 10.5 0.1 2.3 2 0 0 2 2 2 1 PPR repeat ANAPC3 PF12895.7 ETN98150.1 - 0.0062 16.7 0.8 0.023 14.9 0.3 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ETN98150.1 - 0.028 13.9 0.2 0.042 13.3 0.2 1.3 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP DUF627 PF04781.12 ETN98150.1 - 0.029 14.4 0.1 8.9 6.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF627) Pep3_Vps18 PF05131.14 ETN98150.1 - 0.16 11.8 0.0 6.8 6.5 0.0 2.1 2 0 0 2 2 2 0 Pep3/Vps18/deep orange family Fis1_TPR_C PF14853.6 ETN98150.1 - 0.16 12.1 1.7 2.4 8.3 0.1 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Ubiq-assoc PF09145.10 ETN98150.1 - 8.3 6.5 7.6 4.7 7.3 0.4 3.1 3 1 0 3 3 3 0 Ubiquitin-associated COPI_C PF06957.11 ETN98153.1 - 0.13 11.0 23.8 0.29 9.8 23.7 1.6 1 1 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus SIR4_SID PF16991.5 ETN98153.1 - 5.7 7.0 10.0 3.4 7.7 7.8 1.7 1 1 0 1 1 1 0 Sir4 SID domain DUF2457 PF10446.9 ETN98153.1 - 6.1 5.9 23.1 7.9 5.5 23.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2722 PF10846.8 ETN98153.1 - 9.9 5.0 11.9 11 4.9 11.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Sigma70_ner PF04546.13 ETN98154.1 - 0.02 14.7 3.0 0.031 14.2 2.1 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region GCIP PF13324.6 ETN98154.1 - 0.24 11.0 4.4 0.33 10.5 4.4 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting FAM176 PF14851.6 ETN98154.1 - 0.45 10.2 3.4 0.64 9.7 3.4 1.3 1 0 0 1 1 1 0 FAM176 family SpoIIIAH PF12685.7 ETN98154.1 - 0.99 9.2 5.7 4.7 7.0 2.3 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein LAT PF15234.6 ETN98154.1 - 1.3 8.7 7.8 1.7 8.3 7.8 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells DNA_pol_phi PF04931.13 ETN98154.1 - 7 4.6 13.8 9.2 4.2 13.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETN98154.1 - 7.5 5.0 7.5 9.2 4.7 7.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF3959 PF13105.6 ETN98155.1 - 0.26 10.8 1.9 0.28 10.7 1.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) OAD_gamma PF04277.13 ETN98155.1 - 7.7 7.2 9.9 37 5.0 9.9 2.1 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Zip PF02535.22 ETN98156.1 - 1.6e-05 24.3 1.5 1.6e-05 24.3 1.5 2.1 2 0 0 2 2 2 1 ZIP Zinc transporter Menin PF05053.13 ETN98156.1 - 2.7 6.2 15.4 0.035 12.5 8.1 1.5 2 0 0 2 2 2 0 Menin YqfQ PF14181.6 ETN98156.1 - 4.2 7.5 10.8 6.8 6.9 2.8 2.2 2 0 0 2 2 2 0 YqfQ-like protein Ctr PF04145.15 ETN98156.1 - 4.8 7.8 7.8 5.6 7.6 2.4 2.5 2 1 0 2 2 2 0 Ctr copper transporter family Endostatin PF06482.11 ETN98156.1 - 5.3 6.4 11.3 0.78 9.1 5.0 2.0 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin SLC12 PF03522.15 ETN98156.1 - 7.2 5.5 12.3 7.7 5.4 0.9 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Glyco_transf_49 PF13896.6 ETN98158.1 - 1.1e-11 44.7 0.5 5.4e-10 39.1 0.2 2.5 2 0 0 2 2 2 2 Glycosyl-transferase for dystroglycan RNase_H PF00075.24 ETN98159.1 - 2.4e-05 24.5 0.0 0.00014 22.1 0.0 2.0 2 1 0 2 2 2 1 RNase H Fer4_24 PF18109.1 ETN98159.1 - 0.051 13.9 0.0 0.12 12.7 0.0 1.6 1 1 0 1 1 1 0 Ferredoxin I 4Fe-4S cluster domain DUF3265 PF11665.8 ETN98159.1 - 0.19 12.0 0.1 0.4 10.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3265) PhoLip_ATPase_N PF16209.5 ETN98160.1 - 1.1e-19 69.9 7.9 2.2e-17 62.5 7.9 2.4 1 1 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal PGK PF00162.19 ETN98161.1 - 2.3e-96 323.0 1.0 3.7e-96 322.3 1.0 1.3 1 1 0 1 1 1 1 Phosphoglycerate kinase K_oxygenase PF13434.6 ETN98161.1 - 0.062 12.4 0.1 0.4 9.8 0.2 2.1 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) Tat PF00539.18 ETN98164.1 - 0.07 13.3 3.5 0.14 12.4 3.5 1.4 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) CLN3 PF02487.17 ETN98165.1 - 0.093 11.8 0.6 0.1 11.6 0.6 1.1 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 ETN98165.1 - 0.25 10.5 0.4 0.28 10.4 0.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NMN_transporter PF04973.12 ETN98165.1 - 0.45 10.5 5.5 0.62 10.0 5.5 1.5 1 1 0 1 1 1 0 Nicotinamide mononucleotide transporter DUF4922 PF16269.5 ETN98166.1 - 0.094 12.5 0.3 0.12 12.1 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4922) FAM35_C PF15793.5 ETN98167.1 - 0.047 13.1 0.0 0.082 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein family FAM35, C-terminal HSP70 PF00012.20 ETN98168.1 - 2.7e-05 22.6 0.0 0.00034 18.9 0.0 2.2 2 0 0 2 2 2 1 Hsp70 protein Hydantoinase_A PF01968.18 ETN98168.1 - 0.13 11.5 0.0 0.35 10.1 0.0 1.6 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase TelA PF05816.11 ETN98168.1 - 0.22 10.6 3.2 0.12 11.4 0.9 1.7 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) PRKCSH_1 PF13015.6 ETN98170.1 - 1.1e-07 31.7 0.3 1.9e-07 30.9 0.3 1.4 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein Man-6-P_recep PF02157.15 ETN98170.1 - 0.0065 15.6 1.0 0.0079 15.3 0.2 1.5 2 0 0 2 2 2 1 Mannose-6-phosphate receptor GGDEF PF00990.21 ETN98171.1 - 3.9e-05 23.5 0.7 9.6e-05 22.2 0.1 1.8 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain TPR_2 PF07719.17 ETN98172.1 - 0.032 14.3 0.0 0.084 13.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98172.1 - 0.043 14.0 0.1 0.14 12.4 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat JHY PF15261.6 ETN98173.1 - 0.0037 18.0 0.2 0.01 16.6 0.2 1.7 1 0 0 1 1 1 1 Jhy protein WD40 PF00400.32 ETN98174.1 - 6.7e-19 67.9 1.6 4.3e-10 40.0 0.2 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98174.1 - 1.2e-06 28.7 0.1 0.015 15.6 0.0 3.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN98174.1 - 1.2e-05 24.8 0.8 1.6e-05 24.4 0.7 1.3 1 1 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETN98174.1 - 0.00027 20.0 0.1 0.0017 17.4 0.0 2.0 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETN98174.1 - 0.0035 16.1 0.5 0.022 13.5 0.2 1.9 1 1 1 2 2 2 1 Nup133 N terminal like Nup160 PF11715.8 ETN98174.1 - 0.0079 14.9 0.0 0.087 11.5 0.0 2.3 1 1 1 3 3 3 1 Nucleoporin Nup120/160 PD40 PF07676.12 ETN98174.1 - 0.029 14.3 0.1 0.37 10.8 0.0 2.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETN98174.1 - 0.22 11.2 0.2 0.75 9.5 0.2 1.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature YajC PF02699.15 ETN98175.1 - 0.27 11.1 2.7 0.65 9.9 2.7 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Cys_rich_VLP PF14194.6 ETN98176.1 - 0.031 14.4 0.5 0.051 13.7 0.5 1.3 1 0 0 1 1 1 0 Cysteine-rich VLP GNAT_acetyltr_2 PF13718.6 ETN98176.1 - 0.08 12.3 0.1 0.11 11.8 0.1 1.3 1 1 0 1 1 1 0 GNAT acetyltransferase 2 TPR_12 PF13424.6 ETN98177.1 - 2.9e-30 104.3 3.3 5.6e-18 65.0 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98177.1 - 1.9e-27 93.9 24.0 2.4e-08 33.5 2.6 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98177.1 - 6.4e-25 86.3 6.1 1.5e-08 34.2 0.0 4.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98177.1 - 4e-18 64.0 5.1 4.9e-05 23.1 0.2 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98177.1 - 4.9e-18 63.8 20.5 2.4e-07 30.4 1.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98177.1 - 4.4e-17 60.7 18.0 1.5e-07 31.0 2.0 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98177.1 - 2.9e-11 42.9 15.5 0.0034 17.7 0.2 4.9 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98177.1 - 1.8e-10 40.8 1.4 0.072 13.8 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98177.1 - 7.8e-10 38.3 26.6 0.00098 18.8 4.5 6.7 4 1 2 6 6 6 2 TPR repeat TPR_14 PF13428.6 ETN98177.1 - 6.6e-09 35.9 0.0 0.11 13.3 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat SNAP PF14938.6 ETN98177.1 - 2.5e-07 30.4 2.9 3.2e-07 30.1 2.9 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 ETN98177.1 - 1.4e-06 28.8 0.0 1.6 9.4 0.2 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETN98177.1 - 3.6e-06 26.9 13.7 0.027 14.3 0.5 3.4 3 1 0 3 3 3 3 Domain of unknown function (DUF5113) DUF627 PF04781.12 ETN98177.1 - 5.4e-06 26.4 1.1 0.22 11.6 0.1 3.4 3 0 0 3 3 3 1 Protein of unknown function (DUF627) SHNi-TPR PF10516.9 ETN98177.1 - 3.4e-05 23.2 0.4 0.35 10.3 0.0 3.3 3 0 0 3 3 3 2 SHNi-TPR HTH_Bact PF18768.1 ETN98177.1 - 0.00091 18.8 3.5 8.2 6.1 0.0 4.1 4 0 0 4 4 4 0 Helix-turn-helix bacterial domain TPR_19 PF14559.6 ETN98177.1 - 0.0016 18.9 0.6 1.1 9.8 0.0 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETN98177.1 - 0.0034 17.4 11.4 0.14 12.3 0.4 3.9 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETN98177.1 - 0.0036 17.5 13.3 0.32 11.3 1.4 3.5 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 Ubiq-assoc PF09145.10 ETN98177.1 - 0.0055 16.7 14.0 0.62 10.1 0.1 4.6 4 1 0 4 4 4 1 Ubiquitin-associated DUF2959 PF11172.8 ETN98177.1 - 0.034 14.3 0.7 0.68 10.0 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2959) TPR_20 PF14561.6 ETN98177.1 - 0.035 14.4 0.4 13 6.2 0.0 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETN98177.1 - 0.063 13.0 8.1 0.2 11.4 2.0 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 ETN98177.1 - 0.19 12.5 8.5 3.9 8.3 1.1 4.4 3 2 0 3 3 3 0 Sel1 repeat NSF PF02071.20 ETN98177.1 - 0.19 12.6 5.4 13 7.1 0.1 4.4 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat OEP PF02321.18 ETN98177.1 - 0.28 11.0 5.6 5.6 6.7 0.7 2.7 1 1 0 2 2 2 0 Outer membrane efflux protein TAP_C PF03943.13 ETN98177.1 - 0.45 10.2 4.8 4.7 6.9 0.5 3.1 3 0 0 3 3 3 0 TAP C-terminal domain UVR PF02151.19 ETN98177.1 - 1.2 9.0 4.9 7.2 6.5 0.1 3.5 3 1 1 4 4 4 0 UvrB/uvrC motif SPO22 PF08631.10 ETN98177.1 - 4.5 6.7 7.5 9.8 5.6 0.1 3.1 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like Sda PF08970.10 ETN98177.1 - 4.5 7.1 5.2 26 4.6 0.1 3.8 4 0 0 4 4 4 0 Sporulation inhibitor A AAA_6 PF12774.7 ETN98178.1 - 0.09 11.7 0.6 0.12 11.3 0.6 1.3 1 1 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region Kelch_6 PF13964.6 ETN98179.1 - 0.052 13.9 0.0 0.45 10.9 0.0 2.3 2 1 1 3 3 3 0 Kelch motif DUF5041 PF16444.5 ETN98181.1 - 0.038 14.2 0.1 0.042 14.1 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5041) AP3D1 PF06375.11 ETN98181.1 - 3.6 7.8 11.7 4.6 7.5 11.7 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Choline_sulf_C PF12411.8 ETN98182.1 - 0.017 14.9 0.2 0.097 12.5 0.1 2.2 3 0 0 3 3 3 0 Choline sulfatase enzyme C terminal Hema_stalk PF08720.10 ETN98184.1 - 0.014 15.1 0.3 0.016 14.9 0.3 1.2 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk Aegerolysin PF06355.13 ETN98184.1 - 0.026 14.6 0.2 0.03 14.4 0.2 1.1 1 0 0 1 1 1 0 Aegerolysin Na_Ca_ex_C PF16494.5 ETN98184.1 - 0.12 12.8 1.7 0.34 11.4 1.6 1.7 1 1 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain Golgin_A5 PF09787.9 ETN98186.1 - 0.0037 16.8 4.3 0.0037 16.8 4.3 1.3 2 0 0 2 2 2 1 Golgin subfamily A member 5 HMMR_C PF15908.5 ETN98186.1 - 0.0082 16.4 6.5 0.073 13.3 6.5 1.9 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor C-terminal HSBP1 PF06825.12 ETN98186.1 - 0.0091 15.8 2.3 0.016 15.1 2.3 1.5 1 0 0 1 1 1 1 Heat shock factor binding protein 1 TetR_C_4 PF08359.11 ETN98186.1 - 0.0099 16.0 2.9 0.014 15.6 2.9 1.2 1 0 0 1 1 1 1 YsiA-like protein, C-terminal region NPV_P10 PF05531.12 ETN98186.1 - 0.015 15.7 4.3 0.02 15.3 4.0 1.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein MutS_IV PF05190.18 ETN98186.1 - 0.018 15.4 2.4 0.028 14.8 2.4 1.4 1 0 0 1 1 1 0 MutS family domain IV Phage_GP20 PF06810.11 ETN98186.1 - 0.019 14.8 3.0 0.024 14.4 3.0 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 MRP-S32 PF10210.9 ETN98186.1 - 0.023 15.2 1.7 0.034 14.7 1.5 1.4 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 L31 PF09784.9 ETN98186.1 - 0.032 14.7 0.6 0.044 14.2 0.6 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L31 BST2 PF16716.5 ETN98186.1 - 0.034 14.7 4.3 0.075 13.6 4.3 1.7 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 P4Ha_N PF08336.11 ETN98186.1 - 0.051 13.6 4.0 0.059 13.4 4.0 1.1 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Cauli_AT PF03233.13 ETN98186.1 - 0.089 12.7 10.4 0.097 12.6 4.7 2.1 1 1 1 2 2 2 0 Aphid transmission protein USP8_interact PF08941.10 ETN98186.1 - 0.1 12.4 2.6 0.13 12.1 2.6 1.2 1 0 0 1 1 1 0 USP8 interacting FapA PF03961.13 ETN98186.1 - 0.12 11.0 4.3 0.13 10.9 4.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A MtrB PF05440.12 ETN98186.1 - 0.14 12.6 0.0 0.18 12.2 0.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase subunit B Exonuc_VII_L PF02601.15 ETN98186.1 - 0.17 11.4 2.1 0.18 11.4 2.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Swi5 PF07061.11 ETN98186.1 - 0.2 11.7 6.0 0.78 9.9 6.0 1.9 1 1 0 1 1 1 0 Swi5 YjeF_N PF03853.15 ETN98186.1 - 0.21 11.4 0.1 0.24 11.3 0.1 1.1 1 0 0 1 1 1 0 YjeF-related protein N-terminus Sec2p PF06428.11 ETN98186.1 - 0.84 9.6 9.2 2.5 8.1 9.2 1.9 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF3800 PF12686.7 ETN98186.1 - 1.2 9.8 4.3 1.5 9.5 4.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) MetOD2 PF18548.1 ETN98186.1 - 2.5 8.3 8.8 8.4 6.6 2.8 2.7 1 1 1 3 3 3 0 Metanogen output domain 2 Chisel PF15355.6 ETN98188.1 - 0.086 13.1 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Stretch-responsive small skeletal muscle X protein, Chisel SecG PF03840.14 ETN98188.1 - 0.12 12.5 1.7 0.43 10.7 0.0 2.4 2 0 0 2 2 2 0 Preprotein translocase SecG subunit DUF3482 PF11981.8 ETN98188.1 - 0.58 9.5 2.8 0.72 9.2 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) T5orf172 PF10544.9 ETN98190.1 - 0.0075 16.8 1.8 0.012 16.1 0.9 1.7 2 0 0 2 2 2 1 T5orf172 domain KBP_C PF12309.8 ETN98190.1 - 0.28 10.7 5.8 0.66 9.5 5.8 1.6 1 1 0 1 1 1 0 KIF-1 binding protein C terminal Goodbye PF17109.5 ETN98192.1 - 0.013 15.9 0.3 0.017 15.6 0.3 1.1 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain ETRAMP PF09716.10 ETN98192.1 - 0.017 15.1 1.0 0.025 14.6 1.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF1453 PF07301.11 ETN98192.1 - 0.052 13.5 0.0 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1453) ST7 PF04184.12 ETN98192.1 - 0.058 11.9 0.0 0.06 11.8 0.0 1.0 1 0 0 1 1 1 0 ST7 protein DUF819 PF05684.12 ETN98192.1 - 0.079 12.0 0.0 0.086 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF819) Nucleoside_tran PF01733.18 ETN98192.1 - 0.12 11.7 0.1 0.13 11.7 0.1 1.0 1 0 0 1 1 1 0 Nucleoside transporter OAD_gamma PF04277.13 ETN98192.1 - 0.21 12.2 0.1 0.28 11.8 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TetR_C_9 PF14514.6 ETN98193.1 - 2.2e-05 24.6 0.1 0.1 12.7 0.0 2.3 2 0 0 2 2 2 2 Tetracyclin repressor-like, C-terminal domain DNTTIP1_dimer PF18192.1 ETN98193.1 - 7.6e-05 23.0 3.3 0.025 14.9 0.2 2.2 2 0 0 2 2 2 2 DNTTIP1 dimerisation domain DDE_1 PF03184.19 ETN98193.1 - 0.00049 19.8 1.3 0.56 9.8 0.1 2.1 1 1 1 2 2 2 2 DDE superfamily endonuclease CLASP_N PF12348.8 ETN98193.1 - 0.0012 18.4 0.5 1.1 8.8 0.1 2.2 2 0 0 2 2 2 2 CLASP N terminal N_Asn_amidohyd PF14736.6 ETN98193.1 - 0.0025 17.0 0.6 0.51 9.5 0.1 2.0 1 1 1 2 2 2 2 Protein N-terminal asparagine amidohydrolase HEAT_EZ PF13513.6 ETN98193.1 - 0.01 16.4 0.0 7.8 7.1 0.0 3.2 3 0 0 3 3 3 0 HEAT-like repeat DUF5438 PF17506.2 ETN98193.1 - 0.01 16.1 0.0 7.8 6.9 0.0 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5438) PqqD PF05402.12 ETN98193.1 - 0.011 16.1 0.1 6 7.2 0.0 2.3 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) Ribosomal_L29 PF00831.23 ETN98193.1 - 0.012 15.5 0.1 3.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Ribosomal L29 protein DUF4477 PF14780.6 ETN98193.1 - 0.016 14.8 1.9 1.8 8.1 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4477) HEAT PF02985.22 ETN98193.1 - 0.018 15.3 1.3 2.2 8.7 0.0 3.7 4 0 0 4 4 3 0 HEAT repeat Mpv17_PMP22 PF04117.12 ETN98193.1 - 0.025 14.8 0.1 27 5.1 0.0 3.3 2 2 1 3 3 3 0 Mpv17 / PMP22 family UNC45-central PF11701.8 ETN98193.1 - 0.03 14.3 0.1 1.2 9.1 0.0 2.2 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central Coiled-coil_56 PF09813.9 ETN98193.1 - 0.043 13.9 0.4 8.8 6.4 0.1 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 CCDC32 PF14989.6 ETN98193.1 - 0.076 13.0 2.5 2.8 7.9 0.3 2.1 1 1 1 2 2 2 0 Coiled-coil domain containing 32 DUF5477 PF17571.2 ETN98193.1 - 0.078 13.2 0.2 12 6.2 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5477) Methyltr_RsmF_N PF17125.5 ETN98193.1 - 0.088 13.3 0.5 6 7.4 0.1 2.1 2 0 0 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF Aldo_ket_red PF00248.21 ETN98193.1 - 0.13 11.5 1.6 7.7 5.6 0.2 2.5 1 1 0 2 2 2 0 Aldo/keto reductase family Prp19 PF08606.11 ETN98193.1 - 0.15 12.0 3.2 43 4.2 0.0 3.7 3 1 1 4 4 4 0 Prp19/Pso4-like ToxB_N PF18224.1 ETN98193.1 - 0.16 11.9 0.0 15 5.6 0.0 2.2 2 0 0 2 2 2 0 ToxB N-terminal domain VPS13_C PF16909.5 ETN98194.1 - 1.8e-52 177.7 0.2 3.4e-52 176.8 0.2 1.5 1 0 0 1 1 1 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 ETN98194.1 - 3.1e-27 95.6 0.1 6e-27 94.7 0.1 1.5 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 C2 PF00168.30 ETN98194.1 - 1.4e-15 57.4 0.2 1.7e-13 50.7 0.0 3.4 3 0 0 3 3 3 1 C2 domain Ferlin_C PF16165.5 ETN98195.1 - 1 9.3 6.5 2.1 8.2 6.5 1.6 1 0 0 1 1 1 0 Ferlin C-terminus Peptidase_S49_N PF08496.10 ETN98195.1 - 1.4 9.0 4.5 2.1 8.4 4.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SR-25 PF10500.9 ETN98195.1 - 6.8 6.2 17.4 8.2 6.0 17.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dynamin_N PF00350.23 ETN98196.1 - 0.41 10.7 0.0 0.41 10.7 0.0 4.7 5 0 0 5 5 5 0 Dynamin family VWA_2 PF13519.6 ETN98197.1 - 7.9e-09 36.1 0.0 1.8e-07 31.7 0.0 2.6 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETN98197.1 - 6.8e-05 23.2 0.0 0.0015 18.8 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ETN98197.1 - 0.016 14.6 0.0 1.3 8.4 0.0 2.2 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Ssl1 PF04056.14 ETN98197.1 - 0.11 12.3 0.2 3.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Ssl1-like LRR_4 PF12799.7 ETN98198.1 - 2.6e-08 34.0 21.1 0.002 18.5 0.3 4.8 3 2 2 6 6 6 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETN98198.1 - 9.7e-08 31.5 14.0 0.72 10.6 0.2 6.2 4 1 1 5 5 5 4 Leucine Rich Repeat LRR_6 PF13516.6 ETN98198.1 - 1.3e-06 27.9 6.4 0.16 12.1 0.0 5.4 5 0 0 5 5 5 2 Leucine Rich repeat LRR_8 PF13855.6 ETN98198.1 - 2.4e-06 27.2 15.7 0.058 13.2 5.7 5.0 3 1 0 3 3 3 3 Leucine rich repeat GramPos_pilinD1 PF16555.5 ETN98200.1 - 0.36 11.0 4.8 0.63 10.2 3.8 1.8 1 1 1 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain HEAT PF02985.22 ETN98202.1 - 2.3e-08 33.6 0.1 0.015 15.5 0.0 4.0 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ETN98202.1 - 1.4e-07 31.8 0.0 0.0019 18.5 0.0 2.5 3 1 2 5 5 5 2 HEAT repeats RTP1_C1 PF10363.9 ETN98202.1 - 0.0001 22.5 0.1 0.0019 18.4 0.0 2.9 1 1 3 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETN98202.1 - 0.00045 20.3 4.6 0.0019 18.3 2.3 2.4 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETN98202.1 - 0.0026 17.6 1.1 0.19 11.5 0.1 3.4 2 1 1 3 3 3 1 TATA-binding protein interacting (TIP20) FGase PF05013.12 ETN98202.1 - 0.004 17.4 0.0 0.0055 16.9 0.0 1.2 1 0 0 1 1 1 1 N-formylglutamate amidohydrolase DUF2487 PF10673.9 ETN98202.1 - 0.0063 16.5 0.1 0.013 15.6 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2487) DUF3349 PF11829.8 ETN98202.1 - 0.011 16.5 0.7 5.4 7.9 0.0 3.7 3 2 2 5 5 5 0 Protein of unknown function (DUF3349) Ku_PK_bind PF08785.11 ETN98202.1 - 0.016 15.3 2.9 0.92 9.7 0.1 3.0 1 1 1 2 2 2 0 Ku C terminal domain like HEAT_EZ PF13513.6 ETN98202.1 - 0.019 15.4 0.0 4 8.0 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETN98202.1 - 0.028 15.0 0.1 0.78 10.4 0.0 2.5 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region Membr_traf_MHD PF10540.9 ETN98202.1 - 0.033 14.4 0.7 6 7.0 0.0 2.7 1 1 1 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain CRAL_TRIO_2 PF13716.6 ETN98202.1 - 0.047 13.9 0.3 5.8 7.1 0.0 2.7 2 1 1 3 3 3 0 Divergent CRAL/TRIO domain Dmd PF17587.2 ETN98202.1 - 0.059 13.7 0.0 0.43 11.0 0.0 2.2 2 0 0 2 2 2 0 Discriminator of mRNA degradation ZNRF_3_ecto PF18212.1 ETN98202.1 - 0.085 12.9 0.1 0.2 11.7 0.1 1.6 1 0 0 1 1 1 0 ZNRF-3 Ectodomain TAN PF11640.8 ETN98202.1 - 0.15 12.2 5.4 0.25 11.5 0.7 3.2 1 1 1 2 2 2 0 Telomere-length maintenance and DNA damage repair NACHT PF05729.12 ETN98203.1 - 9e-10 38.7 0.0 1.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Rap1a PF18602.1 ETN98203.1 - 0.023 15.0 0.0 0.059 13.7 0.0 1.7 1 0 0 1 1 1 0 Rap1a immunity proteins NPA PF16469.5 ETN98203.1 - 0.034 14.7 0.8 0.93 10.1 0.4 2.4 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 Hexapep PF00132.24 ETN98204.1 - 7e-06 25.6 0.0 0.0033 17.1 0.0 2.6 2 1 1 3 3 3 2 Bacterial transferase hexapeptide (six repeats) DUF1858 PF08984.11 ETN98204.1 - 0.053 13.7 3.8 4.7 7.5 0.4 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF1858) LicD PF04991.13 ETN98206.1 - 0.07 13.3 0.8 0.076 13.1 0.8 1.0 1 0 0 1 1 1 0 LicD family PIP5K PF01504.18 ETN98208.1 - 2.4e-24 86.0 0.6 3.7e-24 85.4 0.6 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3177 PF11375.8 ETN98208.1 - 0.023 14.5 0.2 0.036 13.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3177) CsgA PF17334.2 ETN98208.1 - 0.031 15.0 0.2 0.081 13.7 0.2 1.7 1 0 0 1 1 1 0 Minor curli fiber component A PIP5K PF01504.18 ETN98209.1 - 4.9e-30 104.7 0.0 6.6e-30 104.3 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Ribonuclease_3 PF00636.26 ETN98210.1 - 1.3e-10 41.8 0.1 9.4e-10 39.1 0.1 2.2 1 1 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ETN98210.1 - 1.6e-09 38.0 0.0 2.6e-09 37.3 0.0 1.3 1 0 0 1 1 1 1 Ribonuclease-III-like Adipogenin PF15202.6 ETN98210.1 - 0.023 14.7 0.1 0.023 14.7 0.1 1.8 2 0 0 2 2 2 0 Adipogenin RHD3 PF05879.12 ETN98212.1 - 9.2e-05 20.8 0.1 9.2e-05 20.8 0.1 1.9 2 1 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ETN98212.1 - 0.00026 20.4 0.0 0.00052 19.4 0.0 1.5 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 ETN98212.1 - 0.024 14.7 0.0 0.085 12.9 0.0 2.0 1 0 0 1 1 1 0 Dynamin family Kelch_4 PF13418.6 ETN98213.1 - 9.3e-06 25.6 0.0 0.0026 17.8 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN98213.1 - 0.00078 19.3 0.7 0.08 13.0 0.0 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETN98213.1 - 0.0059 16.2 0.1 0.06 12.9 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN98213.1 - 0.016 15.5 0.0 0.29 11.5 0.0 2.1 2 0 0 2 2 2 0 Kelch motif UQ_con PF00179.26 ETN98215.1 - 2.1e-05 24.2 0.3 2.1e-05 24.2 0.3 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETN98215.1 - 0.00011 22.4 1.2 0.00015 22.1 1.2 1.3 1 1 0 1 1 1 1 RWD domain BRE PF06113.12 ETN98215.1 - 0.0016 17.3 0.1 0.002 17.0 0.1 1.2 1 0 0 1 1 1 1 Brain and reproductive organ-expressed protein (BRE) UEV PF05743.13 ETN98215.1 - 0.036 13.9 0.1 0.065 13.1 0.1 1.6 1 0 0 1 1 1 0 UEV domain SPAN-X PF07458.12 ETN98215.1 - 0.19 12.2 5.1 0.2 12.1 1.2 2.4 2 1 0 2 2 2 0 Sperm protein associated with nucleus, mapped to X chromosome Peptidase_C14 PF00656.22 ETN98216.1 - 4.3e-07 30.1 0.2 5.6e-07 29.8 0.2 1.1 1 0 0 1 1 1 1 Caspase domain Importin_rep_4 PF18808.1 ETN98216.1 - 0.069 13.4 0.2 0.64 10.3 0.0 2.1 2 0 0 2 2 2 0 Importin repeat Csm1_N PF18504.1 ETN98217.1 - 0.00087 19.6 6.7 0.00087 19.6 5.8 1.5 1 1 0 1 1 1 1 Csm1 N-terminal domain TssR PF17643.1 ETN98217.1 - 0.00094 17.3 4.2 0.001 17.2 4.2 1.0 1 0 0 1 1 1 1 Type VI secretion system, TssR VPS38 PF17649.1 ETN98217.1 - 0.0077 15.2 7.9 0.0094 14.9 7.9 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting 38 UPF0240 PF06784.11 ETN98217.1 - 0.018 15.1 3.6 0.022 14.8 3.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) LRAT PF04970.13 ETN98217.1 - 0.045 14.1 1.5 0.051 13.9 1.5 1.1 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Ly49 PF08391.10 ETN98217.1 - 0.49 10.8 10.1 0.75 10.2 10.2 1.3 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region CTP_transf_like PF01467.26 ETN98221.1 - 0.069 13.4 0.3 0.084 13.1 0.3 1.1 1 0 0 1 1 1 0 Cytidylyltransferase-like DNA_pol_E_B PF04042.16 ETN98221.1 - 0.11 11.8 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Cys_rich_VLP PF14194.6 ETN98222.1 - 0.075 13.2 0.9 0.075 13.2 0.9 2.0 2 0 0 2 2 2 0 Cysteine-rich VLP Copine PF07002.16 ETN98223.1 - 1.3e-18 67.3 0.3 1.4e-18 67.2 0.3 1.0 1 0 0 1 1 1 1 Copine WD40 PF00400.32 ETN98224.1 - 0.0036 18.1 6.5 5.1 8.1 0.1 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat HSP90 PF00183.18 ETN98225.1 - 1.1e-42 146.6 11.0 1.9e-28 99.7 1.1 3.5 2 1 1 3 3 3 3 Hsp90 protein SAMP PF05924.11 ETN98226.1 - 0.071 12.4 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 SAMP Motif DUF4667 PF15700.5 ETN98227.1 - 0.19 11.8 10.2 0.62 10.1 10.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) MLVIN_C PF18697.1 ETN98228.1 - 0.00053 20.0 0.0 0.0012 18.9 0.0 1.6 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain SH3_11 PF18103.1 ETN98228.1 - 0.022 14.9 0.0 0.072 13.3 0.0 1.9 2 0 0 2 2 2 0 Retroviral integrase C-terminal SH3 domain SpoIISA_toxin PF14171.6 ETN98231.1 - 0.11 12.2 6.8 0.14 11.8 6.8 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Branch PF02485.21 ETN98233.1 - 0.025 14.1 1.3 0.033 13.7 1.3 1.1 1 0 0 1 1 1 0 Core-2/I-Branching enzyme PUB PF09409.10 ETN98233.1 - 0.057 13.4 5.3 0.068 13.1 2.4 2.4 2 1 0 2 2 2 0 PUB domain Tropomyosin_1 PF12718.7 ETN98234.1 - 0.00036 20.7 19.2 0.091 12.9 10.8 2.4 1 1 1 2 2 2 2 Tropomyosin like TACC_C PF05010.14 ETN98234.1 - 0.0041 16.9 18.8 0.0058 16.4 18.8 1.3 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PolyA_pol PF01743.20 ETN98234.1 - 0.0048 17.3 0.9 0.0065 16.9 0.9 1.4 1 0 0 1 1 1 1 Poly A polymerase head domain CEP209_CC5 PF16574.5 ETN98234.1 - 0.014 15.6 13.6 0.023 14.8 13.6 1.4 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 MPS2 PF17060.5 ETN98234.1 - 0.018 14.3 11.3 0.022 14.0 11.3 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 Atg14 PF10186.9 ETN98234.1 - 0.07 12.2 12.2 0.088 11.9 12.2 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TPR_MLP1_2 PF07926.12 ETN98234.1 - 0.1 12.7 15.2 0.12 12.5 12.9 2.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein HAP1_N PF04849.13 ETN98234.1 - 0.11 11.7 20.4 0.26 10.5 20.4 1.6 1 1 0 1 1 1 0 HAP1 N-terminal conserved region UPF0242 PF06785.11 ETN98234.1 - 0.11 12.6 25.0 0.16 12.1 21.2 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus THOC7 PF05615.13 ETN98234.1 - 0.14 12.5 10.3 0.22 11.8 10.3 1.3 1 0 0 1 1 1 0 Tho complex subunit 7 TMF_DNA_bd PF12329.8 ETN98234.1 - 0.28 11.2 22.7 0.071 13.1 12.3 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding zf-C2HE PF16278.5 ETN98234.1 - 0.44 11.0 0.4 0.44 11.0 0.4 2.7 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger FAM76 PF16046.5 ETN98234.1 - 0.48 9.7 16.7 1.5 8.1 7.5 2.0 1 1 1 2 2 2 0 FAM76 protein DUF2570 PF10828.8 ETN98234.1 - 0.91 9.4 17.0 0.18 11.6 10.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) Seryl_tRNA_N PF02403.22 ETN98234.1 - 1.1 9.5 19.1 0.99 9.7 15.3 2.5 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF745 PF05335.13 ETN98234.1 - 1.6 8.4 10.7 2.8 7.6 10.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Laminin_II PF06009.12 ETN98234.1 - 3.1 7.8 14.6 0.56 10.2 9.4 2.1 1 1 1 2 2 2 0 Laminin Domain II APG6_N PF17675.1 ETN98234.1 - 3.4 8.2 16.5 11 6.6 15.6 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETN98234.1 - 4.7 7.3 15.3 2.1 8.4 10.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ETN98234.1 - 7.5 6.7 20.8 7.8 6.7 18.3 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family BRE1 PF08647.11 ETN98234.1 - 7.8 6.6 24.9 0.68 10.0 13.8 2.7 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Ephrin_rec_like PF07699.13 ETN98238.1 - 0.021 14.6 0.5 0.029 14.1 0.5 1.2 1 0 0 1 1 1 0 Putative ephrin-receptor like zf-LITAF-like PF10601.9 ETN98238.1 - 0.25 11.6 1.4 0.5 10.7 0.5 2.1 1 1 1 2 2 2 0 LITAF-like zinc ribbon domain Peptidase_C14 PF00656.22 ETN98240.1 - 2.3e-10 40.9 1.7 3.7e-10 40.2 1.7 1.4 1 1 0 1 1 1 1 Caspase domain DUF1106 PF06523.11 ETN98240.1 - 0.023 14.8 0.7 0.045 13.8 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1106) RTP1_C1 PF10363.9 ETN98241.1 - 0.0018 18.5 5.9 0.2 11.8 0.3 4.6 5 1 1 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 ETN98241.1 - 0.037 14.3 0.0 65 4.2 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat DUF573 PF04504.14 ETN98241.1 - 0.42 11.3 8.0 31 5.3 0.1 5.3 4 2 1 5 5 5 0 Protein of unknown function, DUF573 RPAP3_C PF13877.6 ETN98241.1 - 0.44 11.1 9.4 12 6.5 0.7 6.0 4 2 1 6 6 6 0 Potential Monad-binding region of RPAP3 CAP_GLY PF01302.25 ETN98242.1 - 6.4e-14 51.7 0.2 1.1e-13 51.0 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain GatB_Yqey PF02637.18 ETN98243.1 - 0.015 15.2 0.1 0.022 14.7 0.1 1.3 1 0 0 1 1 1 0 GatB domain MIF4G PF02854.19 ETN98245.1 - 1.2e-09 38.2 2.8 1.2e-09 38.2 2.8 2.0 2 0 0 2 2 2 1 MIF4G domain YqzH PF14164.6 ETN98245.1 - 0.33 11.1 0.1 0.33 11.1 0.1 3.1 4 0 0 4 4 4 0 YqzH-like protein putAbiC PF16872.5 ETN98246.1 - 0.093 13.4 4.1 1.5 9.6 4.1 2.3 1 1 0 1 1 1 0 Putative phage abortive infection protein AIG1 PF04548.16 ETN98249.1 - 0.035 13.4 0.6 0.048 13.0 0.5 1.3 1 1 0 1 1 1 0 AIG1 family Orf78 PF06024.12 ETN98250.1 - 0.0071 16.6 2.0 0.0071 16.6 2.0 2.8 2 1 1 3 3 3 2 Orf78 (ac78) U-box PF04564.15 ETN98251.1 - 3.5e-14 52.7 0.1 8.9e-14 51.4 0.1 1.7 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETN98251.1 - 0.038 14.1 0.0 0.065 13.4 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETN98251.1 - 0.093 12.6 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit DNApol_Exo PF18136.1 ETN98251.1 - 0.12 11.5 0.0 0.15 11.1 0.0 1.1 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain NACHT PF05729.12 ETN98252.1 - 0.00065 19.7 0.0 0.00091 19.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain RNA_pol_Rpb1_7 PF04990.12 ETN98252.1 - 0.34 10.9 6.2 1.6 8.7 0.5 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 7 CAP_GLY PF01302.25 ETN98254.1 - 2.9e-07 30.4 0.0 4.2e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Phage_T7_Capsid PF05396.11 ETN98255.1 - 0.0073 16.7 0.0 0.01 16.2 0.0 1.2 1 0 0 1 1 1 1 Phage T7 capsid assembly protein LpxI_N PF17930.1 ETN98255.1 - 0.05 13.5 0.0 0.069 13.0 0.0 1.3 1 1 0 1 1 1 0 LpxI N-terminal domain Mac PF12464.8 ETN98255.1 - 0.069 13.4 0.9 0.23 11.7 0.4 2.2 2 1 0 2 2 2 0 Maltose acetyltransferase KIP1 PF07765.12 ETN98255.1 - 0.15 12.2 0.2 0.3 11.2 0.0 1.7 2 0 0 2 2 2 0 KIP1-like protein Kelch_1 PF01344.25 ETN98256.1 - 0.11 12.0 4.4 1.2 8.8 0.5 2.7 3 0 0 3 3 3 0 Kelch motif Ripply PF14998.6 ETN98256.1 - 0.14 12.8 0.2 0.31 11.7 0.2 1.6 1 0 0 1 1 1 0 Transcription Regulator RT_RNaseH_2 PF17919.1 ETN98257.1 - 1.9e-19 69.6 0.1 7.8e-19 67.6 0.0 1.8 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETN98257.1 - 8.7e-07 29.2 0.0 1.9e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Collagen_bind_2 PF12904.7 ETN98257.1 - 0.033 14.2 0.0 0.048 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative collagen-binding domain of a collagenase PUB PF09409.10 ETN98259.1 - 0.0035 17.2 2.6 0.018 15.0 2.6 2.0 1 1 0 1 1 1 1 PUB domain Dymeclin PF09742.9 ETN98259.1 - 0.023 13.2 0.5 0.025 13.0 0.5 1.0 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein PDT PF00800.18 ETN98259.1 - 0.043 13.6 0.2 0.071 12.9 0.1 1.5 2 0 0 2 2 2 0 Prephenate dehydratase DUF2171 PF09939.9 ETN98260.1 - 0.11 12.8 1.4 0.14 12.4 0.2 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2171) ABC_tran_CTD PF16326.5 ETN98261.1 - 0.0072 16.6 5.9 0.0072 16.6 5.9 3.6 1 1 2 3 3 3 1 ABC transporter C-terminal domain L_lactis_ph-MCP PF06673.11 ETN98261.1 - 0.024 13.6 2.7 0.034 13.1 2.7 1.2 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein ApoO PF09769.9 ETN98261.1 - 0.91 9.5 3.2 2 8.4 2.6 2.1 1 1 0 1 1 1 0 Apolipoprotein O FAM76 PF16046.5 ETN98261.1 - 1.6 8.0 25.6 2.1 7.6 25.6 1.1 1 0 0 1 1 1 0 FAM76 protein RsgA_GTPase PF03193.16 ETN98262.1 - 0.0095 15.9 1.4 0.017 15.1 1.4 1.4 1 1 0 1 1 1 1 RsgA GTPase Thioredoxin_2 PF13098.6 ETN98262.1 - 0.094 13.2 1.6 1.7 9.1 0.0 2.2 1 1 1 2 2 2 0 Thioredoxin-like domain AIG1 PF04548.16 ETN98262.1 - 0.27 10.5 4.5 0.47 9.8 0.0 2.4 2 1 0 2 2 2 0 AIG1 family Dna2 PF08696.11 ETN98262.1 - 0.32 10.8 4.2 0.28 10.9 3.5 1.3 1 1 0 1 1 1 0 DNA replication factor Dna2 KMP11 PF03037.16 ETN98262.1 - 1.8 9.4 11.5 0.11 13.3 3.7 2.0 2 0 0 2 2 2 0 Kinetoplastid membrane protein 11 PKcGMP_CC PF16808.5 ETN98263.1 - 0.044 13.6 4.3 0.074 12.9 4.3 1.4 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CC2-LZ PF16516.5 ETN98263.1 - 0.067 13.6 5.7 0.081 13.3 5.7 1.1 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Bap31_Bap29_C PF18035.1 ETN98263.1 - 0.11 12.5 6.5 0.2 11.7 6.5 1.4 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF641 PF04859.12 ETN98263.1 - 0.23 11.8 4.6 0.32 11.3 4.6 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF4239 PF14023.6 ETN98263.1 - 3.2 7.4 6.5 0.72 9.5 1.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) LRR_4 PF12799.7 ETN98264.1 - 1.3e-06 28.6 5.5 0.12 12.8 0.3 3.7 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETN98264.1 - 0.0013 18.4 3.1 0.037 13.8 2.3 3.0 2 1 2 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 ETN98264.1 - 0.74 10.6 5.4 11 7.0 0.1 4.2 4 1 0 4 4 4 0 Leucine Rich Repeat CREPT PF16566.5 ETN98265.1 - 0.014 15.5 0.3 0.022 14.9 0.3 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour IBN_N PF03810.19 ETN98266.1 - 0.14 12.1 1.7 0.28 11.1 1.7 1.7 1 1 0 1 1 1 0 Importin-beta N-terminal domain Antimicrobial12 PF08107.11 ETN98266.1 - 0.35 10.6 0.1 0.35 10.6 0.1 1.9 3 0 0 3 3 3 0 Pleurocidin family DUF3819 PF12842.7 ETN98267.1 - 0.064 13.2 0.4 0.081 12.9 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) WD40 PF00400.32 ETN98270.1 - 6.1e-36 121.8 31.0 8.2e-07 29.6 0.9 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98270.1 - 3.9e-10 39.9 0.4 0.33 11.3 0.0 5.9 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98270.1 - 4.4e-09 35.5 10.3 0.6 8.7 0.1 5.9 2 2 3 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN98270.1 - 1.9e-06 27.4 4.7 0.057 12.7 0.8 4.2 2 2 2 4 4 4 3 WD40-like domain Dynamin_M PF01031.20 ETN98271.1 - 0.019 14.2 0.3 0.023 13.9 0.3 1.1 1 0 0 1 1 1 0 Dynamin central region BNR_6 PF15899.5 ETN98271.1 - 0.58 10.4 3.4 6 7.2 0.6 2.6 2 0 0 2 2 2 0 BNR-Asp box repeat TPR_1 PF00515.28 ETN98274.1 - 7.4e-23 79.4 20.7 1.8e-06 27.5 1.8 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_12 PF13424.6 ETN98274.1 - 7.7e-22 77.4 5.3 1.3e-09 38.2 0.4 3.0 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98274.1 - 2.3e-18 64.8 3.6 0.00096 19.0 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98274.1 - 6.5e-17 60.2 14.6 3.1e-06 26.9 1.4 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98274.1 - 5.5e-16 57.4 16.4 2.2e-05 24.3 1.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98274.1 - 2.4e-15 55.8 12.2 1.3e-05 24.8 0.3 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98274.1 - 8.9e-10 39.1 0.7 0.00093 19.8 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98274.1 - 3.5e-09 36.7 4.5 0.0078 16.8 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98274.1 - 9.5e-08 32.3 0.0 0.44 11.5 0.0 4.0 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98274.1 - 6.8e-06 25.7 20.7 0.024 14.3 3.8 5.0 4 2 2 6 6 6 3 TPR repeat ANAPC3 PF12895.7 ETN98274.1 - 9.7e-05 22.5 11.1 0.06 13.6 1.1 3.2 2 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETN98274.1 - 0.00014 21.9 19.0 0.61 10.2 3.1 4.2 1 1 2 4 4 4 3 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETN98274.1 - 0.00035 20.1 7.8 0.0046 16.4 5.3 2.6 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_5 PF12688.7 ETN98274.1 - 0.00055 20.2 0.2 0.0083 16.4 0.0 2.4 1 1 0 2 2 2 1 Tetratrico peptide repeat SHNi-TPR PF10516.9 ETN98274.1 - 0.00058 19.3 2.1 1.6 8.3 0.1 3.5 4 0 0 4 4 4 1 SHNi-TPR TPR_19 PF14559.6 ETN98274.1 - 0.0021 18.5 3.8 0.26 11.8 0.3 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98274.1 - 0.0027 18.0 16.2 0.04 14.3 1.7 4.3 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETN98274.1 - 0.0032 17.4 1.9 0.0032 17.4 1.9 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat HTH_Bact PF18768.1 ETN98274.1 - 0.01 15.4 1.7 4.6 6.9 0.3 3.3 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain Sel1 PF08238.12 ETN98274.1 - 0.012 16.3 8.5 0.93 10.3 0.3 4.3 4 2 0 4 4 4 0 Sel1 repeat PPR PF01535.20 ETN98274.1 - 0.015 15.5 0.1 23 5.5 0.0 3.9 4 0 0 4 4 4 0 PPR repeat DUF627 PF04781.12 ETN98274.1 - 0.089 12.8 0.8 3.8 7.6 0.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF627) DUF5113 PF17140.4 ETN98274.1 - 0.12 12.1 14.4 1.1 9.1 0.2 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) Fis1_TPR_C PF14853.6 ETN98274.1 - 4.1 7.6 9.1 3.1 7.9 1.3 3.2 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat DUF4099 PF13351.6 ETN98275.1 - 0.028 14.7 0.0 0.052 13.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4099) Ca_bind_SSO6904 PF18249.1 ETN98275.1 - 0.2 12.0 3.0 7.3 7.0 0.3 2.8 2 1 1 3 3 3 0 Calcium binding protein SSO6904 DLP_helical PF18709.1 ETN98275.1 - 0.46 9.6 4.1 2.5 7.2 0.3 2.1 1 1 1 2 2 2 0 Dynamin-like helical domain DUF4416 PF14385.6 ETN98276.1 - 0.13 12.2 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) ATG16 PF08614.11 ETN98278.1 - 0.74 10.0 10.9 1.9 8.6 10.0 1.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Ovate PF04844.13 ETN98280.1 - 0.051 13.6 0.2 0.14 12.1 0.2 1.7 1 0 0 1 1 1 0 Transcriptional repressor, ovate WD40 PF00400.32 ETN98282.1 - 1.6e-30 104.6 26.7 9.1e-07 29.5 2.7 7.2 7 1 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 ETN98282.1 - 7.7e-08 31.4 2.3 0.0076 14.9 0.1 4.2 2 2 1 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98282.1 - 4.6e-07 30.0 0.5 1.5 9.1 0.0 4.9 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN98282.1 - 5.7e-05 22.1 8.0 0.5 9.1 1.0 4.0 2 2 2 4 4 4 4 Nup133 N terminal like DUF4979 PF16351.5 ETN98282.1 - 0.11 12.7 0.2 12 6.1 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4979) DUF2085 PF09858.9 ETN98285.1 - 0.05 14.1 0.0 0.066 13.7 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2085) HTH_40 PF14493.6 ETN98285.1 - 0.1 13.0 0.1 0.2 12.1 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain RsgA_GTPase PF03193.16 ETN98286.1 - 8.4e-07 29.0 0.8 2.2e-05 24.4 0.8 2.2 1 1 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ETN98286.1 - 4.4e-06 26.8 0.8 4.1e-05 23.6 0.3 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETN98286.1 - 3.3e-05 24.4 0.0 3.9e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 ETN98286.1 - 7.3e-05 22.9 1.1 0.17 12.0 0.0 2.3 1 1 0 2 2 2 2 Dynamin family AAA_29 PF13555.6 ETN98286.1 - 0.0011 18.7 0.1 0.002 17.8 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ETN98286.1 - 0.0013 19.2 0.2 0.0022 18.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETN98286.1 - 0.0053 17.0 0.0 0.0073 16.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain T2SSE PF00437.20 ETN98286.1 - 0.0093 15.1 0.1 0.013 14.6 0.1 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein Septin PF00735.18 ETN98286.1 - 0.015 14.6 0.0 0.023 14.0 0.0 1.2 1 0 0 1 1 1 0 Septin Zeta_toxin PF06414.12 ETN98286.1 - 0.025 13.9 0.1 0.039 13.2 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_28 PF13521.6 ETN98286.1 - 0.025 14.8 0.4 0.039 14.2 0.4 1.6 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 ETN98286.1 - 0.028 13.6 0.2 0.04 13.1 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ETN98286.1 - 0.03 14.1 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 ETN98286.1 - 0.034 13.7 0.0 0.052 13.1 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain MCM PF00493.23 ETN98286.1 - 0.037 13.1 0.1 0.056 12.5 0.1 1.2 1 0 0 1 1 1 0 MCM P-loop domain TsaE PF02367.17 ETN98286.1 - 0.041 13.9 0.2 0.068 13.2 0.2 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PhoH PF02562.16 ETN98286.1 - 0.042 13.3 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 ETN98286.1 - 0.053 13.9 0.1 0.068 13.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETN98286.1 - 0.062 12.8 0.1 0.095 12.2 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Ploopntkinase3 PF18751.1 ETN98286.1 - 0.062 13.2 0.0 0.084 12.8 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 SRP54 PF00448.22 ETN98286.1 - 0.068 12.8 0.7 0.23 11.1 0.7 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_33 PF13671.6 ETN98286.1 - 0.098 12.8 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETN98286.1 - 0.16 11.7 0.0 0.42 10.3 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Cpn60_TCP1 PF00118.24 ETN98287.1 - 7.8e-06 24.8 0.1 1.1e-05 24.3 0.1 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Myosin_head PF00063.21 ETN98288.1 - 1.6e-63 215.1 0.0 2e-63 214.8 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) CDC45 PF02724.14 ETN98289.1 - 0.0026 16.2 3.5 0.0029 16.0 3.5 1.1 1 0 0 1 1 1 1 CDC45-like protein Zip PF02535.22 ETN98289.1 - 0.021 14.1 0.8 0.024 13.9 0.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Corazonin PF17308.2 ETN98289.1 - 0.089 13.2 14.3 0.16 12.3 14.3 1.4 1 0 0 1 1 1 0 Pro-corazonin CLN3 PF02487.17 ETN98289.1 - 0.18 10.8 2.1 0.22 10.5 2.1 1.1 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 ETN98289.1 - 0.3 9.8 4.8 0.36 9.6 4.8 1.1 1 0 0 1 1 1 0 Presenilin PRP1_N PF06424.12 ETN98289.1 - 0.39 11.1 14.6 0.057 13.8 10.7 1.5 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal NST1 PF13945.6 ETN98289.1 - 0.4 10.8 16.4 0.57 10.3 16.4 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Gti1_Pac2 PF09729.9 ETN98289.1 - 0.42 10.7 7.2 0.54 10.3 7.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4834 PF16118.5 ETN98289.1 - 0.45 11.5 4.2 0.73 10.8 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Pox_Ag35 PF03286.14 ETN98289.1 - 0.48 10.2 7.8 0.74 9.6 7.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CPSF100_C PF13299.6 ETN98289.1 - 0.71 10.0 4.1 0.92 9.7 4.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Apis_Csd PF11671.8 ETN98289.1 - 0.96 9.5 11.1 1.6 8.7 11.1 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein RNA_pol_Rpc4 PF05132.14 ETN98289.1 - 0.98 9.8 4.9 1.5 9.2 4.9 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Tim54 PF11711.8 ETN98289.1 - 3.3 6.4 7.4 4.8 5.9 7.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TFB6 PF17110.5 ETN98289.1 - 3.6 7.3 7.4 7 6.4 7.4 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CobT PF06213.12 ETN98289.1 - 3.8 6.8 9.1 5.2 6.4 9.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Secretin_N_2 PF07655.13 ETN98289.1 - 6.2 7.4 18.2 15 6.2 18.2 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Cpn60_TCP1 PF00118.24 ETN98291.1 - 4.6e-19 68.4 0.5 2.3e-18 66.1 0.5 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF2726 PF10881.8 ETN98291.1 - 0.018 15.0 0.0 0.036 14.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) PP2 PF14299.6 ETN98292.1 - 0.26 11.3 3.8 13 5.8 0.0 2.3 2 0 0 2 2 2 0 Phloem protein 2 Ppx-GppA PF02541.16 ETN98295.1 - 3.3e-11 43.2 0.1 5.1e-11 42.5 0.0 1.5 2 0 0 2 2 2 1 Ppx/GppA phosphatase family PilM_2 PF11104.8 ETN98295.1 - 0.043 12.8 0.1 0.14 11.2 0.0 1.8 1 1 1 2 2 2 0 Type IV pilus assembly protein PilM; MMR_HSR1 PF01926.23 ETN98296.1 - 2.9e-22 78.9 0.0 5.4e-22 78.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETN98296.1 - 1.8e-11 43.8 0.1 2.6e-11 43.3 0.1 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ETN98296.1 - 1.1e-07 32.0 0.0 8.4e-05 22.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ETN98296.1 - 5.2e-06 26.1 0.2 0.0007 19.2 0.2 2.5 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Septin PF00735.18 ETN98296.1 - 8.4e-06 25.3 2.2 0.00047 19.5 2.3 2.9 2 1 0 2 2 2 1 Septin Dynamin_N PF00350.23 ETN98296.1 - 5.8e-05 23.2 0.1 0.16 12.0 0.2 2.6 1 1 1 2 2 2 2 Dynamin family IIGP PF05049.13 ETN98296.1 - 0.011 14.9 0.0 0.018 14.1 0.0 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) MMR_HSR1_Xtn PF16897.5 ETN98296.1 - 0.017 15.1 0.2 0.035 14.1 0.2 1.5 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain DUF4020 PF13212.6 ETN98296.1 - 0.035 13.9 0.8 1.9 8.3 0.0 3.0 2 2 1 3 3 3 0 Domain of unknown function (DUF4020) Roc PF08477.13 ETN98296.1 - 0.042 14.1 0.1 0.25 11.5 0.0 2.4 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETN98296.1 - 0.043 13.2 0.1 0.11 11.9 0.0 1.7 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit DUF2813 PF11398.8 ETN98296.1 - 0.052 12.8 0.7 1.2 8.4 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2813) AIG1 PF04548.16 ETN98296.1 - 0.053 12.8 0.1 0.094 12.0 0.1 1.3 1 0 0 1 1 1 0 AIG1 family AAA_22 PF13401.6 ETN98296.1 - 0.11 12.8 0.2 0.42 10.9 0.0 2.1 2 2 0 2 2 2 0 AAA domain HTH_12 PF08461.10 ETN98296.1 - 0.16 12.0 0.0 0.42 10.6 0.0 1.7 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain Secretin_N_2 PF07655.13 ETN98297.1 - 8.1e-07 29.5 8.0 1.7e-06 28.5 8.0 1.5 1 0 0 1 1 1 1 Secretin N-terminal domain Secretin PF00263.21 ETN98297.1 - 6.6e-06 25.9 2.1 9.1e-06 25.4 0.5 2.1 2 1 0 2 2 2 1 Bacterial type II and III secretion system protein STN PF07660.14 ETN98297.1 - 0.08 12.8 0.1 1.5 8.7 0.0 2.6 1 1 1 2 2 2 0 Secretin and TonB N terminus short domain HTH_Tnp_Tc3_2 PF01498.18 ETN98299.1 - 6.8e-09 35.8 0.1 1.3e-08 35.0 0.1 1.5 1 0 0 1 1 1 1 Transposase PX PF00787.24 ETN98300.1 - 7e-13 48.5 0.6 1.6e-12 47.4 0.6 1.6 1 0 0 1 1 1 1 PX domain Mlo PF03094.15 ETN98301.1 - 0.012 14.0 0.9 0.014 13.8 0.9 1.1 1 0 0 1 1 1 0 Mlo family Ribosomal_S17_N PF16205.5 ETN98301.1 - 2.4 8.6 7.8 6.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Ribosomal_S17 N-terminal Cnd1 PF12717.7 ETN98302.1 - 0.00012 22.1 0.2 0.00015 21.8 0.2 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETN98302.1 - 0.00035 20.6 0.2 8.3 7.0 0.0 3.3 3 0 0 3 3 3 2 HEAT repeat TIP120 PF08623.10 ETN98302.1 - 0.00056 19.7 1.0 1.4 8.7 0.0 2.6 1 1 2 3 3 3 3 TATA-binding protein interacting (TIP20) Vac14_Fab1_bd PF12755.7 ETN98302.1 - 0.0088 16.6 0.2 0.2 12.3 0.0 2.2 1 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT_2 PF13646.6 ETN98302.1 - 0.011 16.1 0.0 0.46 10.9 0.0 2.3 1 1 1 2 2 2 0 HEAT repeats Imm30 PF15565.6 ETN98302.1 - 0.026 14.6 0.5 0.068 13.2 0.3 1.8 1 1 1 2 2 2 0 Immunity protein 30 RTP1_C1 PF10363.9 ETN98302.1 - 0.035 14.3 0.0 0.072 13.3 0.0 1.5 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 TPR_12 PF13424.6 ETN98303.1 - 2e-73 242.7 24.7 2.6e-17 62.9 0.1 6.2 2 1 6 8 8 8 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98303.1 - 1.7e-40 135.8 2.8 1.1e-06 28.3 0.0 8.5 9 0 0 9 9 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98303.1 - 1.8e-36 122.5 43.6 6e-08 32.2 1.0 8.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98303.1 - 1.5e-30 103.0 14.5 4.2e-06 26.4 0.0 7.7 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98303.1 - 2.3e-24 83.5 41.2 2.7e-05 24.0 2.3 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98303.1 - 2.7e-23 80.1 34.0 1.4e-07 31.0 0.9 8.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98303.1 - 2.3e-10 40.1 5.8 1.2 9.6 0.0 6.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98303.1 - 1.3e-09 38.1 7.5 0.025 15.2 0.1 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98303.1 - 4e-09 37.0 0.5 1.1 10.0 0.0 6.6 5 2 1 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98303.1 - 1.4e-08 34.2 40.2 0.00052 19.6 0.8 8.2 8 1 1 9 9 9 4 TPR repeat TPR_14 PF13428.6 ETN98303.1 - 5e-08 33.1 0.9 3.6 8.6 0.0 6.5 6 2 2 8 8 6 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETN98303.1 - 6.5e-05 22.8 22.1 0.017 14.9 0.5 6.8 6 1 1 7 7 7 1 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETN98303.1 - 0.00072 19.5 31.0 1.4 9.0 0.2 7.1 8 0 0 8 8 8 3 Tetratricopeptide repeat DUF4810 PF16068.5 ETN98303.1 - 0.0045 17.5 4.2 9.1 6.9 0.1 5.0 4 1 1 5 5 5 0 Domain of unknown function (DUF4810) SPO22 PF08631.10 ETN98303.1 - 0.012 15.1 5.6 0.93 8.9 0.1 3.6 3 1 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like Thg1 PF04446.12 ETN98303.1 - 0.015 15.3 1.5 28 4.8 0.0 4.2 2 1 1 3 3 3 0 tRNAHis guanylyltransferase Alpha-amylase_N PF02903.14 ETN98303.1 - 0.017 15.3 10.8 9.3 6.5 0.2 4.8 1 1 3 4 4 4 0 Alpha amylase, N-terminal ig-like domain Phage_ABA_S PF18066.1 ETN98303.1 - 0.27 12.0 3.0 0.45 11.2 1.1 2.4 2 0 0 2 2 2 0 Phage ABA sandwich domain PPR PF01535.20 ETN98303.1 - 0.41 11.0 8.1 6.1 7.3 0.1 5.3 5 0 0 5 5 5 0 PPR repeat ANAPC3 PF12895.7 ETN98303.1 - 0.77 10.0 14.1 0.99 9.7 0.8 5.1 3 2 3 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 HisK_sensor PF18698.1 ETN98303.1 - 1.6 9.1 11.2 0.49 10.8 1.9 2.8 1 1 0 2 2 2 0 Histidine kinase sensor domain Cys_rich_VLP PF14194.6 ETN98304.1 - 0.03 14.4 1.0 0.071 13.2 0.3 1.8 2 0 0 2 2 2 0 Cysteine-rich VLP NACHT PF05729.12 ETN98305.1 - 0.00038 20.4 0.0 0.00087 19.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETN98305.1 - 0.022 14.4 0.5 0.053 13.2 0.5 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) CUE PF02845.16 ETN98306.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 CUE domain RRM_1 PF00076.22 ETN98307.1 - 5.5e-22 77.4 0.0 2.1e-09 37.1 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETN98307.1 - 0.0072 15.9 0.0 4.3 7.0 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phycobilisome PF00502.19 ETN98307.1 - 0.035 14.0 0.0 0.063 13.2 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome protein DnaJ_C PF01556.18 ETN98310.1 - 4.2e-27 95.0 0.0 5.1e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETN98310.1 - 0.093 13.1 0.1 0.14 12.6 0.1 1.3 1 0 0 1 1 1 0 DnaJ central domain zf_CopZ PF18423.1 ETN98310.1 - 0.16 11.9 0.2 0.32 11.0 0.2 1.5 1 0 0 1 1 1 0 Zinc binding domain Dus PF01207.17 ETN98311.1 - 7.7e-08 31.8 0.0 9e-08 31.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DEAD PF00270.29 ETN98313.1 - 2.3e-29 102.4 0.7 1.4e-28 99.9 0.3 2.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETN98313.1 - 5.2e-20 71.8 1.9 7.5e-20 71.3 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ETN98313.1 - 1.1e-05 24.3 0.2 3.3e-05 22.8 0.2 1.8 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETN98313.1 - 0.00018 21.6 0.6 0.00059 19.9 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Thump_like PF18096.1 ETN98313.1 - 5.4 7.0 6.7 16 5.5 0.3 3.5 3 0 0 3 3 3 0 THUMP domain-like F-box PF00646.33 ETN98314.1 - 0.0073 16.2 0.2 0.02 14.8 0.2 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETN98314.1 - 0.031 14.2 0.3 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 F-box-like WD40 PF00400.32 ETN98315.1 - 5.5e-17 61.8 5.7 2.8e-05 24.8 0.1 4.5 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98315.1 - 0.00017 21.8 0.4 3.2 8.1 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98315.1 - 0.0077 14.9 0.3 0.27 9.8 0.0 2.6 1 1 1 2 2 2 1 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETN98315.1 - 0.012 15.8 0.8 9.9 6.4 0.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) Nucleoporin_N PF08801.11 ETN98315.1 - 0.027 13.2 0.7 0.19 10.5 0.7 2.0 1 1 0 1 1 1 0 Nup133 N terminal like Rieske_2 PF13806.6 ETN98315.1 - 0.12 12.3 0.0 0.93 9.5 0.0 2.2 1 1 1 2 2 2 0 Rieske-like [2Fe-2S] domain TraI_2_C PF07515.11 ETN98317.1 - 0.19 11.7 1.7 0.39 10.7 0.1 2.3 3 0 0 3 3 3 0 Putative conjugal transfer nickase/helicase TraI C-term zf-C2HE PF16278.5 ETN98318.1 - 0.0024 18.3 0.7 0.0032 17.9 0.7 1.5 1 1 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger DUF2500 PF10694.9 ETN98319.1 - 1.5 9.4 7.8 0.15 12.6 3.3 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Fis1_TPR_C PF14853.6 ETN98320.1 - 0.026 14.6 0.2 0.044 13.9 0.2 1.4 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 ETN98320.1 - 0.051 13.8 0.2 0.094 13.0 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat F-112 PF09645.10 ETN98321.1 - 0.0078 16.3 1.4 0.0078 16.3 1.4 1.6 2 0 0 2 2 2 1 F-112 protein Exo_endo_phos_2 PF14529.6 ETN98322.1 - 0.023 14.5 0.6 0.05 13.4 0.6 1.7 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase zf-CRD PF17979.1 ETN98322.1 - 0.044 13.9 0.1 0.068 13.3 0.1 1.3 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions PseudoU_synth_2 PF00849.22 ETN98323.1 - 0.011 15.9 0.2 0.014 15.5 0.2 1.1 1 0 0 1 1 1 0 RNA pseudouridylate synthase HD_assoc PF13286.6 ETN98323.1 - 0.27 11.8 1.2 0.39 11.3 0.2 1.7 2 0 0 2 2 2 0 Phosphohydrolase-associated domain Zmiz1_N PF18028.1 ETN98324.1 - 0.045 14.1 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Zmiz1 N-terminal tetratricopeptide repeat domain MFS_1 PF07690.16 ETN98325.1 - 1.1e-23 83.8 13.7 1.3e-23 83.6 13.7 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETN98325.1 - 9.3e-09 34.7 6.0 9.3e-09 34.7 6.0 1.4 1 1 1 2 2 2 1 Sugar (and other) transporter OATP PF03137.20 ETN98325.1 - 0.041 12.2 1.6 0.041 12.2 1.6 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MFS_1_like PF12832.7 ETN98325.1 - 0.3 9.9 4.9 0.37 9.6 4.9 1.1 1 0 0 1 1 1 0 MFS_1 like family SAM_1 PF00536.30 ETN98326.1 - 7.1e-08 32.8 2.3 1.3e-07 31.9 2.3 1.5 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN98326.1 - 9.6e-08 32.0 1.4 1.5e-07 31.4 1.4 1.4 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETN98326.1 - 0.053 13.5 2.0 0.16 11.9 2.0 1.8 1 1 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain SAM_4 PF18017.1 ETN98326.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Exonuc_VII_L PF02601.15 ETN98327.1 - 2.9 7.4 16.2 3.2 7.2 16.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tetraspanin PF00335.20 ETN98328.1 - 0.37 10.5 9.5 0.039 13.7 4.3 1.9 1 1 0 2 2 2 0 Tetraspanin family AP-5_subunit_s1 PF15001.6 ETN98331.1 - 0.088 12.8 2.0 3.4 7.6 0.1 2.1 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 WD40 PF00400.32 ETN98334.1 - 1.6e-58 193.3 21.0 8e-08 32.8 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98334.1 - 6e-20 71.3 3.2 0.00063 20.0 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98334.1 - 1.6e-18 66.8 1.3 0.0012 17.9 0.0 6.2 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETN98334.1 - 4.5e-07 28.9 8.7 0.067 11.8 0.1 4.7 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN98334.1 - 0.023 14.0 9.6 0.062 12.6 0.1 3.8 2 1 2 5 5 5 0 WD40-like domain PD40 PF07676.12 ETN98334.1 - 0.045 13.7 6.0 24 5.0 0.0 5.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat ETRAMP PF09716.10 ETN98335.1 - 0.016 15.3 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PT PF04886.12 ETN98335.1 - 0.16 11.5 48.4 0.034 13.7 26.6 3.7 2 1 0 2 2 2 0 PT repeat ORC6 PF05460.13 ETN98335.1 - 0.26 10.5 5.8 0.44 9.8 5.8 1.4 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF1623 PF07785.11 ETN98336.1 - 0.011 15.8 0.4 0.018 15.2 0.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1623) Cpn60_TCP1 PF00118.24 ETN98337.1 - 5.3e-12 45.1 0.1 5.3e-12 45.1 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GTP-bdg_M PF16360.5 ETN98337.1 - 0.022 15.4 1.7 0.86 10.2 0.2 2.2 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region ChlI PF13541.6 ETN98337.1 - 0.038 13.8 0.1 0.058 13.2 0.1 1.2 1 0 0 1 1 1 0 Subunit ChlI of Mg-chelatase HalX PF08663.10 ETN98337.1 - 0.079 13.3 0.9 8.4 6.8 0.9 2.2 2 0 0 2 2 2 0 HalX domain HAMP_N3 PF18575.1 ETN98337.1 - 0.16 11.5 0.6 18 5.0 0.2 2.2 2 0 0 2 2 2 0 HAMP N-terminal domain 3 CENP-Q PF13094.6 ETN98339.1 - 0.033 14.4 12.4 0.024 14.9 10.9 1.6 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit GCIP PF13324.6 ETN98339.1 - 0.033 13.8 5.8 0.04 13.5 5.8 1.0 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting 7TMR-HDED PF07697.11 ETN98339.1 - 0.42 10.7 10.3 0.54 10.3 10.3 1.3 1 0 0 1 1 1 0 7TM-HD extracellular ALMT PF11744.8 ETN98339.1 - 0.61 8.9 9.1 0.29 9.9 6.8 1.3 1 1 0 1 1 1 0 Aluminium activated malate transporter DUF745 PF05335.13 ETN98339.1 - 0.98 9.1 9.4 0.6 9.8 7.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Tfb5 PF06331.12 ETN98339.1 - 1.1 9.3 11.6 4.6 7.3 0.4 3.1 2 1 1 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 Peptidase_M76 PF09768.9 ETN98339.1 - 1.1 9.0 7.2 5 6.9 7.2 1.9 1 1 0 1 1 1 0 Peptidase M76 family ABC2_membrane_3 PF12698.7 ETN98339.1 - 1.6 7.8 5.5 2 7.4 5.5 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein PIN_8 PF18476.1 ETN98339.1 - 1.8 8.4 12.7 0.34 10.7 8.4 1.7 1 1 1 2 2 2 0 PIN like domain HNOBA PF07701.14 ETN98339.1 - 6.5 6.1 14.2 0.36 10.2 7.3 1.9 2 0 0 2 2 2 0 Heme NO binding associated BAAT_C PF08840.11 ETN98339.1 - 8.4 6.2 8.6 2.4 8.0 2.1 2.0 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF1043 PF06295.12 ETN98339.1 - 9.7 6.2 16.9 5.6 7.0 11.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) Kelch_6 PF13964.6 ETN98340.1 - 1.6e-08 34.5 2.6 0.032 14.5 0.1 4.6 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETN98340.1 - 1.7e-05 24.7 0.4 0.051 13.6 0.0 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98340.1 - 6.1e-05 22.5 0.1 0.036 13.6 0.0 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETN98340.1 - 0.00078 19.4 3.5 0.099 12.7 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETN98340.1 - 0.023 15.0 0.0 17 5.9 0.0 3.0 2 0 0 2 2 2 0 Galactose oxidase, central domain tRNA-synt_1b PF00579.25 ETN98341.1 - 1.7e-42 145.8 0.3 2.2e-42 145.4 0.0 1.3 2 0 0 2 2 2 1 tRNA synthetases class I (W and Y) T6PP_N PF18572.1 ETN98341.1 - 0.078 12.8 1.1 0.29 11.0 1.1 1.9 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain zf-RING_2 PF13639.6 ETN98342.1 - 3.4e-10 40.1 8.6 3.4e-10 40.1 8.6 2.0 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 ETN98342.1 - 2.8e-09 36.5 8.9 4.3e-09 35.9 4.2 2.6 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETN98342.1 - 5.2e-06 26.2 5.5 5.2e-06 26.2 5.5 2.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETN98342.1 - 8.7e-05 22.4 4.4 8.7e-05 22.4 4.4 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETN98342.1 - 0.0007 19.8 9.9 0.0007 19.8 9.9 2.8 1 1 2 3 3 3 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETN98342.1 - 0.0011 19.0 6.9 0.0016 18.4 1.4 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETN98342.1 - 0.003 17.4 5.5 0.003 17.4 5.5 2.3 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) PigN PF04987.14 ETN98342.1 - 0.0089 14.9 0.3 0.012 14.6 0.3 1.0 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) FAM176 PF14851.6 ETN98342.1 - 0.016 14.9 1.3 0.022 14.4 1.3 1.2 1 0 0 1 1 1 0 FAM176 family GP67 PF17634.2 ETN98342.1 - 0.022 15.1 1.5 0.036 14.5 1.5 1.2 1 0 0 1 1 1 0 Gene product 67 Acatn PF13000.7 ETN98342.1 - 0.025 13.1 0.2 0.03 12.8 0.2 1.0 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Prok-RING_4 PF14447.6 ETN98342.1 - 0.036 13.9 5.3 0.1 12.5 5.3 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 MAP17 PF15807.5 ETN98342.1 - 0.068 13.4 3.8 0.098 12.9 3.8 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Ctr PF04145.15 ETN98342.1 - 0.2 12.2 0.1 0.24 12.0 0.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Cytomega_UL84 PF06284.11 ETN98342.1 - 2 6.8 3.7 2.3 6.6 3.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Peptidase_S49_N PF08496.10 ETN98342.1 - 5.9 6.9 6.5 9.3 6.3 6.5 1.3 1 1 0 1 1 1 0 Peptidase family S49 N-terminal TolA_bind_tri PF16331.5 ETN98343.1 - 0.00011 22.1 5.7 0.00011 22.1 5.7 2.6 2 1 0 3 3 3 1 TolA binding protein trimerisation DUF4407 PF14362.6 ETN98343.1 - 0.00089 18.7 22.1 0.001 18.5 22.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF2347 PF09804.9 ETN98343.1 - 3.2 7.2 6.2 3.3 7.2 5.8 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DASH_Spc19 PF08287.11 ETN98343.1 - 3.5 7.5 24.1 0.12 12.3 15.6 2.1 1 1 1 2 2 2 0 Spc19 DUF16 PF01519.16 ETN98343.1 - 4.6 7.8 18.8 0.083 13.4 7.0 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 Exo_endo_phos_2 PF14529.6 ETN98344.1 - 0.00047 20.0 0.1 0.0012 18.7 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-RVT PF13966.6 ETN98344.1 - 0.0049 17.6 0.3 0.01 16.5 0.3 1.5 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase DUF4046 PF13255.6 ETN98344.1 - 0.0096 16.5 0.1 0.021 15.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF4046) Imm63 PF15599.6 ETN98344.1 - 0.09 13.2 0.2 3.4 8.1 0.0 2.8 3 0 0 3 3 3 0 Immunity protein 63 DUF1048 PF06304.11 ETN98345.1 - 0.00024 21.5 0.1 0.00041 20.8 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1048) Suppressor_APC PF11414.8 ETN98345.1 - 0.091 12.8 3.1 0.11 12.5 1.3 2.1 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein zf-CCHC PF00098.23 ETN98347.1 - 0.013 15.5 1.1 0.027 14.5 1.1 1.6 1 0 0 1 1 1 0 Zinc knuckle Minor_capsid_3 PF12691.7 ETN98349.1 - 0.061 13.7 1.1 0.12 12.8 0.9 1.6 1 1 0 1 1 1 0 Minor capsid protein from bacteriophage Phage_Gp23 PF10669.9 ETN98349.1 - 0.35 11.2 14.5 1.5 9.1 8.7 2.4 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) DUF3482 PF11981.8 ETN98349.1 - 0.57 9.5 3.9 0.86 8.9 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) AAA_24 PF13479.6 ETN98350.1 - 1e-05 25.4 0.8 0.096 12.4 0.3 2.3 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ETN98350.1 - 0.0003 21.2 0.0 0.00089 19.7 0.0 1.9 2 1 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETN98350.1 - 0.0013 19.0 0.1 0.0056 17.0 0.0 2.2 2 1 0 2 2 2 1 AAA domain TniB PF05621.11 ETN98350.1 - 0.0085 15.5 0.0 0.035 13.5 0.0 1.9 2 0 0 2 2 2 1 Bacterial TniB protein IstB_IS21 PF01695.17 ETN98350.1 - 0.013 15.3 0.0 0.16 11.7 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Nrap_D3 PF17404.2 ETN98350.1 - 0.034 14.2 0.5 0.065 13.3 0.5 1.4 1 0 0 1 1 1 0 Nrap protein domain 3 RsgA_GTPase PF03193.16 ETN98350.1 - 0.17 11.8 0.1 0.57 10.1 0.0 1.8 1 1 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 ETN98350.1 - 0.29 11.6 2.9 0.88 10.0 0.6 3.1 2 2 2 4 4 4 0 RNA helicase DUF3800 PF12686.7 ETN98350.1 - 2.8 8.6 4.8 8.1 7.1 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3800) DUF87 PF01935.17 ETN98350.1 - 3.5 7.6 7.2 2.6 8.1 0.1 2.8 3 1 0 3 3 3 0 Helicase HerA, central domain NACHT PF05729.12 ETN98352.1 - 0.047 13.6 0.0 0.059 13.3 0.0 1.2 1 0 0 1 1 1 0 NACHT domain Trypan_PARP PF05887.11 ETN98353.1 - 0.033 14.2 11.0 0.048 13.6 11.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PPP4R2 PF09184.11 ETN98353.1 - 0.78 9.3 28.8 0.96 9.0 28.8 1.1 1 0 0 1 1 1 0 PPP4R2 Sfi1 PF08457.10 ETN98355.1 - 0.0029 16.2 0.6 0.0041 15.7 0.6 1.1 1 0 0 1 1 1 1 Sfi1 spindle body protein Cys_rich_VLP PF14194.6 ETN98355.1 - 0.0072 16.4 0.2 0.016 15.3 0.2 1.5 1 0 0 1 1 1 1 Cysteine-rich VLP Herpes_TK_C PF08465.10 ETN98356.1 - 0.1 12.3 0.2 0.27 11.0 0.2 1.7 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal RicinB_lectin_2 PF14200.6 ETN98357.1 - 0.046 14.4 0.0 0.22 12.3 0.0 1.7 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like WD40 PF00400.32 ETN98358.1 - 2.3e-64 211.8 29.8 4.4e-11 43.2 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98358.1 - 5.9e-23 81.0 5.6 4.1e-05 23.8 0.1 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN98358.1 - 3.6e-09 36.4 7.2 0.0017 17.8 0.3 4.0 1 1 4 6 6 6 4 WD40-like domain Nup160 PF11715.8 ETN98358.1 - 4.5e-09 35.5 5.1 0.68 8.5 0.0 6.5 1 1 5 7 7 7 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETN98358.1 - 1.9e-08 33.6 0.5 0.016 14.2 0.0 5.5 1 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETN98358.1 - 2.3e-05 23.1 0.4 0.018 13.6 0.0 2.7 2 1 1 3 3 3 3 Cytochrome D1 heme domain NHL PF01436.21 ETN98358.1 - 0.00041 20.2 0.9 1.7 8.8 0.0 4.2 4 0 0 4 4 4 1 NHL repeat Nucleoporin_N PF08801.11 ETN98358.1 - 0.00087 18.1 10.8 0.72 8.5 0.1 4.8 2 1 1 5 5 5 2 Nup133 N terminal like VID27 PF08553.10 ETN98358.1 - 0.0011 18.1 0.0 1.4 7.9 0.0 3.1 2 1 1 3 3 3 1 VID27 C-terminal WD40-like domain PQQ PF01011.21 ETN98358.1 - 0.0044 16.9 0.0 34 4.6 0.0 4.1 3 0 0 3 3 3 0 PQQ enzyme repeat Resistin PF06954.11 ETN98358.1 - 0.03 14.9 0.3 3.5 8.2 0.0 3.4 3 1 1 4 4 4 0 Resistin DUF4221 PF13970.6 ETN98358.1 - 0.05 13.2 1.7 7.1 6.1 0.0 3.7 1 1 2 4 4 4 0 Domain of unknown function (DUF4221) PALB2_WD40 PF16756.5 ETN98358.1 - 0.058 12.3 4.6 0.21 10.5 0.0 3.6 2 1 2 5 5 5 0 Partner and localizer of BRCA2 WD40 domain DUF727 PF05303.12 ETN98358.1 - 0.075 13.1 0.6 3 7.9 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF727) DUF2415 PF10313.9 ETN98358.1 - 0.4 10.6 1.5 15 5.6 0.0 3.0 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) Pkinase PF00069.25 ETN98359.1 - 5.4e-58 196.4 0.2 6.3e-58 196.2 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98359.1 - 1e-33 116.7 0.0 1.1e-33 116.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ETN98359.1 - 8.9e-06 25.4 0.2 1.3e-05 24.9 0.2 1.2 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 ETN98359.1 - 1.9e-05 24.2 0.0 2.5e-05 23.7 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETN98359.1 - 0.00041 20.3 0.2 0.016 15.2 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETN98359.1 - 0.0028 17.1 0.3 0.0044 16.4 0.3 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETN98359.1 - 0.0063 15.5 0.2 0.0078 15.2 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain YukC PF10140.9 ETN98359.1 - 0.017 14.0 0.1 0.023 13.6 0.1 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Choline_kinase PF01633.20 ETN98359.1 - 0.12 11.9 0.3 0.23 11.0 0.3 1.6 1 1 0 1 1 1 0 Choline/ethanolamine kinase Urocanase PF01175.18 ETN98361.1 - 0.077 12.6 0.6 0.18 11.5 0.6 1.6 1 0 0 1 1 1 0 Urocanase Rossmann-like domain CENP-H PF05837.12 ETN98361.1 - 0.35 11.3 34.7 0.23 11.9 8.1 4.0 2 2 2 4 4 4 0 Centromere protein H (CENP-H) USP8_interact PF08941.10 ETN98361.1 - 1.3 8.8 11.1 0.9 9.3 3.1 2.8 2 0 0 2 2 2 0 USP8 interacting DUF948 PF06103.11 ETN98361.1 - 3.7 7.9 9.8 4.4 7.6 1.7 3.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CEP63 PF17045.5 ETN98361.1 - 4.3 7.2 37.6 0.11 12.4 29.8 2.1 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa DUF848 PF05852.11 ETN98361.1 - 4.7 7.3 21.0 5.4 7.1 2.9 3.0 2 1 1 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1664 PF07889.12 ETN98361.1 - 9.8 6.2 15.1 11 6.0 3.8 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) TLD PF07534.16 ETN98362.1 - 7.6e-13 48.9 0.1 1.9e-12 47.6 0.1 1.7 1 0 0 1 1 1 1 TLD DUF190 PF02641.15 ETN98362.1 - 0.011 16.0 0.1 0.049 14.0 0.1 2.2 1 1 0 1 1 1 0 Uncharacterized ACR, COG1993 Acid_PPase PF12689.7 ETN98362.1 - 0.022 14.6 3.2 0.054 13.3 3.2 1.7 1 1 0 1 1 1 0 Acid Phosphatase RAMP4 PF06624.12 ETN98362.1 - 0.11 12.5 0.0 0.5 10.5 0.0 2.1 1 0 0 1 1 1 0 Ribosome associated membrane protein RAMP4 TFIIA PF03153.13 ETN98363.1 - 0.0083 16.2 24.6 0.011 15.7 24.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Roughex PF06020.11 ETN98363.1 - 2 7.4 10.5 2.6 7.1 10.5 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3123 PF11321.8 ETN98363.1 - 2.3 8.9 5.4 9.8 6.9 0.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3123) Ndc1_Nup PF09531.10 ETN98363.1 - 4.9 5.7 9.3 5.3 5.6 9.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Metallophos PF00149.28 ETN98365.1 - 7.2e-12 46.2 2.7 1e-11 45.7 2.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETN98365.1 - 2.7e-08 34.2 0.5 0.0099 16.1 0.1 2.5 2 1 0 2 2 2 2 Calcineurin-like phosphoesterase superfamily domain BcrAD_BadFG PF01869.20 ETN98369.1 - 0.19 11.2 0.0 0.25 10.8 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Ecm33 PF12454.8 ETN98370.1 - 0.08 13.1 0.1 0.25 11.5 0.1 1.9 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Peptidase_S49_N PF08496.10 ETN98372.1 - 0.0011 19.0 5.4 0.0015 18.6 5.4 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DUF4614 PF15391.6 ETN98372.1 - 0.0048 16.9 6.4 0.0063 16.5 6.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4614) CDC45 PF02724.14 ETN98372.1 - 0.027 12.8 4.0 0.027 12.8 4.0 1.0 1 0 0 1 1 1 0 CDC45-like protein PPL5 PF18168.1 ETN98372.1 - 0.04 13.2 2.6 0.045 13.0 2.6 1.2 1 0 0 1 1 1 0 Prim-pol family 5 GAGA_bind PF06217.12 ETN98372.1 - 0.057 13.7 10.5 0.069 13.4 10.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 ETN98372.1 - 0.096 11.4 5.2 0.096 11.4 5.2 1.1 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 ETN98372.1 - 0.12 12.5 4.1 0.11 12.5 4.1 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DAG_kinase_N PF14513.6 ETN98372.1 - 0.12 12.5 3.8 0.17 12.1 3.8 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus EOS1 PF12326.8 ETN98372.1 - 0.2 11.6 2.3 0.25 11.2 2.3 1.3 1 0 0 1 1 1 0 N-glycosylation protein NPR3 PF03666.13 ETN98372.1 - 0.24 10.1 7.9 0.25 10.1 7.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2828 PF11443.8 ETN98372.1 - 0.29 9.2 9.6 0.38 8.8 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RNA_pol_Rpc4 PF05132.14 ETN98372.1 - 0.43 11.0 7.0 0.61 10.5 7.0 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 MAP17 PF15807.5 ETN98372.1 - 0.43 10.8 7.7 0.74 10.0 7.7 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Connexin PF00029.19 ETN98372.1 - 0.46 10.2 6.9 0.65 9.7 6.9 1.2 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ETN98372.1 - 0.55 9.4 3.5 0.56 9.4 3.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3807 PF12720.7 ETN98372.1 - 0.65 10.2 15.0 1 9.6 15.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CBP_BcsG PF11658.8 ETN98372.1 - 0.67 8.3 5.3 0.8 8.0 4.5 1.5 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsG DUF2370 PF10176.9 ETN98372.1 - 0.71 9.5 4.2 0.95 9.1 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) NARP1 PF12569.8 ETN98372.1 - 0.8 8.5 12.4 1.3 7.9 12.4 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Otopetrin PF03189.13 ETN98372.1 - 1.2 7.9 2.6 1.3 7.8 2.6 1.1 1 0 0 1 1 1 0 Otopetrin Neur_chan_memb PF02932.16 ETN98372.1 - 1.4 9.0 4.6 1.5 8.8 4.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region YqfQ PF14181.6 ETN98372.1 - 1.4 9.1 11.9 2.1 8.5 11.9 1.2 1 0 0 1 1 1 0 YqfQ-like protein MDFI PF15316.6 ETN98372.1 - 1.6 8.8 5.4 2.5 8.2 5.4 1.2 1 0 0 1 1 1 0 MyoD family inhibitor RR_TM4-6 PF06459.12 ETN98372.1 - 1.9 8.2 12.8 2.7 7.7 12.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 ETN98372.1 - 2 8.0 6.1 4.5 6.9 6.1 1.7 1 1 0 1 1 1 0 FAM176 family Serinc PF03348.15 ETN98372.1 - 3.5 6.4 3.9 4.9 6.0 3.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) ALMT PF11744.8 ETN98372.1 - 4.9 5.9 7.9 6.5 5.5 7.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CSG2 PF16965.5 ETN98372.1 - 6.1 5.7 6.0 8.3 5.2 6.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator V_ATPase_I PF01496.19 ETN98372.1 - 7.6 4.3 10.2 10 3.9 10.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 ETN98372.1 - 8.5 5.3 6.2 11 4.9 6.2 1.1 1 0 0 1 1 1 0 CLN3 protein O-antigen_lig PF13425.6 ETN98372.1 - 9.6 4.9 8.3 13 4.4 8.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Orf78 PF06024.12 ETN98373.1 - 0.53 10.6 2.7 0.58 10.5 2.7 1.1 1 0 0 1 1 1 0 Orf78 (ac78) XAP5 PF04921.14 ETN98373.1 - 2.8 7.7 10.1 2.7 7.8 10.1 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF4637 PF15470.6 ETN98373.1 - 4.8 6.9 14.1 5.2 6.8 14.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) BBE PF08031.12 ETN98374.1 - 0.051 13.7 1.5 1.9 8.6 0.2 2.6 2 0 0 2 2 2 0 Berberine and berberine like NLRC4_HD2 PF17776.1 ETN98374.1 - 0.63 10.6 0.2 0.63 10.6 0.2 2.7 3 0 0 3 3 3 0 NLRC4 helical domain HD2 DNA_pol3_delta2 PF13177.6 ETN98375.1 - 0.051 13.4 2.4 3.4 7.4 0.1 2.4 2 0 0 2 2 2 0 DNA polymerase III, delta subunit STI1 PF17830.1 ETN98378.1 - 0.00076 19.4 0.8 0.16 12.0 0.0 3.1 3 0 0 3 3 3 2 STI1 domain NACHT PF05729.12 ETN98379.1 - 0.00021 21.3 0.0 0.00056 19.9 0.0 1.8 1 0 0 1 1 1 1 NACHT domain TsaE PF02367.17 ETN98379.1 - 0.0026 17.8 0.2 1.1 9.3 0.0 2.5 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 ETN98379.1 - 0.0066 15.8 0.0 0.052 12.9 0.0 2.4 3 0 0 3 3 3 1 KaiC RsgA_GTPase PF03193.16 ETN98379.1 - 0.017 15.0 0.0 0.042 13.8 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ETN98379.1 - 0.019 15.2 0.0 0.054 13.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETN98379.1 - 0.02 14.6 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETN98379.1 - 0.033 14.8 0.2 0.31 11.6 0.0 2.7 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETN98379.1 - 0.038 13.7 0.0 1.1 9.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETN98379.1 - 0.048 14.0 0.0 0.22 11.9 0.0 2.2 1 0 0 1 1 1 0 RNA helicase Sigma54_activat PF00158.26 ETN98379.1 - 0.1 12.3 0.0 0.25 11.0 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain T2SSE PF00437.20 ETN98379.1 - 0.12 11.5 0.0 0.32 10.0 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein WD40 PF00400.32 ETN98380.1 - 9.3e-42 140.2 11.5 4.2e-07 30.6 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98380.1 - 8.6e-13 48.4 4.0 0.023 15.0 0.0 6.2 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETN98380.1 - 2.5e-07 30.8 0.8 0.0061 16.5 0.1 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETN98380.1 - 2.3e-05 23.3 9.7 0.1 11.3 0.1 4.5 2 1 3 6 6 6 3 Nucleoporin Nup120/160 Utp8 PF10395.9 ETN98380.1 - 0.00012 20.8 5.9 0.0019 16.8 0.1 3.0 2 2 0 3 3 3 2 Utp8 family Ge1_WD40 PF16529.5 ETN98380.1 - 0.00014 21.0 1.8 0.016 14.2 0.0 3.7 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN98380.1 - 0.00029 20.2 13.2 0.0012 18.3 1.9 4.0 2 1 2 5 5 5 3 WD40-like domain BBS2_Mid PF14783.6 ETN98380.1 - 0.01 15.8 3.7 4.7 7.3 0.0 4.4 2 2 2 4 4 4 0 Ciliary BBSome complex subunit 2, middle region PALB2_WD40 PF16756.5 ETN98380.1 - 0.059 12.3 3.3 3.8 6.3 0.0 3.9 1 1 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain MraZ PF02381.18 ETN98380.1 - 0.11 12.5 0.7 3.1 7.9 0.1 3.1 2 1 1 3 3 3 0 MraZ protein, putative antitoxin-like DUF2316 PF10078.9 ETN98381.1 - 0.025 14.8 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2316) DUF3108 PF11306.8 ETN98381.1 - 0.032 14.2 0.0 0.033 14.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) Thymopoietin PF08198.11 ETN98381.1 - 0.068 12.8 0.1 0.13 11.8 0.1 1.4 1 0 0 1 1 1 0 Thymopoietin protein WD40 PF00400.32 ETN98382.1 - 2.3e-06 28.2 0.2 4.6e-06 27.3 0.2 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat Exo_endo_phos_2 PF14529.6 ETN98382.1 - 0.11 12.3 2.0 0.16 11.9 2.0 1.2 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase Gp58 PF07902.11 ETN98382.1 - 0.27 9.5 5.9 0.32 9.2 5.9 1.0 1 0 0 1 1 1 0 gp58-like protein ADIP PF11559.8 ETN98382.1 - 0.39 10.8 16.7 0.56 10.3 16.7 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding AvrM_N PF18247.1 ETN98382.1 - 0.61 10.1 4.5 0.51 10.3 2.9 1.7 1 1 1 2 2 2 0 Flax-rust effector AvrM N-terminal domain OmpH PF03938.14 ETN98382.1 - 0.69 10.2 14.9 0.97 9.8 14.9 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMF_DNA_bd PF12329.8 ETN98382.1 - 2.3 8.3 27.5 0.23 11.5 11.7 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding FapA PF03961.13 ETN98382.1 - 3.8 6.0 14.0 4.3 5.8 14.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 ETN98382.1 - 5.7 6.1 10.5 6.4 5.9 10.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein SlyX PF04102.12 ETN98382.1 - 8.4 7.1 9.7 4.6 7.9 2.1 2.3 1 1 1 2 2 2 0 SlyX DUF1664 PF07889.12 ETN98382.1 - 8.6 6.4 9.0 14 5.8 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4834 PF16118.5 ETN98384.1 - 6.6 7.8 8.4 6.9 7.7 8.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TPR_12 PF13424.6 ETN98385.1 - 3.6e-30 104.1 5.5 2.6e-16 59.6 0.6 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98385.1 - 2.3e-22 77.8 14.8 1.5e-07 30.9 0.9 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98385.1 - 1.5e-19 69.2 0.4 3.1e-05 23.7 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98385.1 - 3.1e-18 64.3 9.8 2.7e-05 23.9 0.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98385.1 - 3.3e-16 58.1 14.3 3.8e-05 23.6 0.9 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98385.1 - 8.8e-14 50.4 0.3 0.0014 18.6 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98385.1 - 1.7e-09 37.2 13.0 0.0034 17.1 0.6 3.8 3 2 0 3 3 3 3 TPR repeat TPR_6 PF13174.6 ETN98385.1 - 3.3e-08 33.6 0.1 0.1 13.2 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98385.1 - 1.4e-07 31.4 8.2 0.029 14.8 0.3 3.7 3 2 0 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.6 ETN98385.1 - 3.2e-05 23.5 1.8 4.6e-05 23.0 1.8 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 ETN98385.1 - 6.2e-05 23.1 6.5 0.0016 18.7 1.4 2.4 1 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETN98385.1 - 6.9e-05 23.4 0.0 1 10.1 0.0 2.9 1 1 0 2 2 2 2 Tetratricopeptide repeat DUF627 PF04781.12 ETN98385.1 - 0.00076 19.5 4.4 3.8 7.6 0.0 3.2 2 1 2 4 4 4 1 Protein of unknown function (DUF627) HTH_Bact PF18768.1 ETN98385.1 - 0.001 18.6 0.7 6.2 6.5 0.0 3.3 3 0 0 3 3 3 1 Helix-turn-helix bacterial domain TPR_14 PF13428.6 ETN98385.1 - 0.0023 18.6 0.0 20 6.3 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Prefoldin PF02996.17 ETN98385.1 - 0.003 17.5 1.6 0.52 10.2 0.0 2.9 2 1 1 3 3 3 1 Prefoldin subunit TPR_3 PF07720.12 ETN98385.1 - 0.0037 17.2 9.3 0.029 14.4 0.9 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETN98385.1 - 0.0081 16.0 10.5 0.27 11.0 0.3 3.0 1 1 2 3 3 3 1 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETN98385.1 - 0.024 14.4 3.2 3.1 7.5 1.0 2.1 2 0 0 2 2 2 0 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 ETN98385.1 - 0.03 13.8 0.4 9.4 5.8 0.0 2.8 3 0 0 3 3 3 0 SHNi-TPR Mistic PF11458.8 ETN98385.1 - 0.05 13.6 3.4 9.4 6.3 0.1 3.0 3 0 0 3 3 3 0 Membrane-integrating protein Mistic MbeB_N PF04837.12 ETN98385.1 - 0.094 13.0 0.7 19 5.6 0.0 2.8 3 0 0 3 3 3 0 MbeB-like, N-term conserved region DUF2225 PF09986.9 ETN98385.1 - 0.1 12.3 6.3 1.7 8.3 6.3 2.0 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) TOM20_plant PF06552.12 ETN98385.1 - 0.11 12.3 3.3 2.9 7.6 0.5 2.8 1 1 1 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 SPG4 PF17325.2 ETN98385.1 - 3.2 8.9 9.8 2.6 9.2 2.7 3.1 1 1 2 3 3 3 0 Stationary phase protein 4 SPO22 PF08631.10 ETN98385.1 - 3.2 7.1 7.8 25 4.2 0.4 2.9 1 1 2 3 3 3 0 Meiosis protein SPO22/ZIP4 like DUF4298 PF14131.6 ETN98385.1 - 3.8 7.6 8.6 10 6.2 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) MIT PF04212.18 ETN98385.1 - 6.3 7.0 11.4 11 6.2 0.3 3.0 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain KKLCAg1 PF15204.6 ETN98388.1 - 0.59 10.3 3.0 0.32 11.1 0.5 1.9 2 0 0 2 2 2 0 Kita-kyushu lung cancer antigen 1 CD20 PF04103.15 ETN98388.1 - 3.3 7.8 6.5 0.42 10.7 1.7 1.9 2 0 0 2 2 2 0 CD20-like family SPARC_Ca_bdg PF10591.9 ETN98389.1 - 0.064 13.6 1.4 0.11 12.8 0.3 1.8 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region RPN2_C PF18004.1 ETN98390.1 - 0.019 14.9 17.6 0.019 14.9 17.6 2.0 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain PPP4R2 PF09184.11 ETN98390.1 - 0.083 12.5 18.4 0.11 12.1 18.4 1.2 1 0 0 1 1 1 0 PPP4R2 BSP_II PF05432.11 ETN98390.1 - 2.7 7.6 22.0 4 7.1 22.0 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Folate_carrier PF01770.18 ETN98390.1 - 2.8 6.6 4.1 3.6 6.2 4.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier Sec62 PF03839.16 ETN98390.1 - 4.3 6.8 13.9 22 4.5 10.7 2.0 2 0 0 2 2 2 0 Translocation protein Sec62 CLN3 PF02487.17 ETN98390.1 - 4.4 6.2 4.4 7 5.6 4.4 1.3 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 ETN98390.1 - 7.7 5.2 12.0 8.6 5.0 12.0 1.1 1 0 0 1 1 1 0 Presenilin FAM83 PF07894.12 ETN98390.1 - 9.2 5.7 10.7 2 7.9 5.8 1.9 2 0 0 2 2 2 0 FAM83 A-H DUF4667 PF15700.5 ETN98391.1 - 5.5e-06 26.7 5.0 6.2e-06 26.5 5.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4667) BUD22 PF09073.10 ETN98391.1 - 0.0015 17.9 0.5 0.0016 17.9 0.5 1.1 1 0 0 1 1 1 1 BUD22 Chorion_2 PF03964.15 ETN98391.1 - 0.06 14.2 8.4 0.1 13.4 8.4 1.4 1 0 0 1 1 1 0 Chorion family 2 RHINO PF15319.6 ETN98391.1 - 0.13 12.2 2.9 0.17 11.9 2.9 1.1 1 0 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein SPX PF03105.19 ETN98391.1 - 0.15 12.0 9.2 0.18 11.7 9.2 1.1 1 0 0 1 1 1 0 SPX domain Herpes_capsid PF06112.11 ETN98391.1 - 0.18 11.9 15.8 0.24 11.4 15.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CCDC106 PF15794.5 ETN98391.1 - 0.43 10.3 11.9 0.73 9.5 11.9 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Apt1 PF10351.9 ETN98391.1 - 0.55 9.0 11.1 0.69 8.7 11.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ETN98391.1 - 0.75 8.3 14.5 1 7.8 14.5 1.2 1 0 0 1 1 1 0 Macoilin family Secretin_N_2 PF07655.13 ETN98391.1 - 1.2 9.7 21.2 2.5 8.7 21.2 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4614 PF15391.6 ETN98391.1 - 1.3 9.0 17.7 2 8.4 17.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) RAP1 PF07218.11 ETN98391.1 - 2.5 6.2 15.5 3 6.0 15.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1635 PF07795.11 ETN98391.1 - 2.6 7.8 10.9 3.8 7.3 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) CCDC24 PF15669.5 ETN98391.1 - 4.6 7.1 10.0 6.5 6.6 10.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family PAP1 PF08601.10 ETN98391.1 - 6.7 6.3 21.2 8.6 6.0 21.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 CARMIL_C PF16000.5 ETN98392.1 - 0.0089 15.7 3.5 0.01 15.5 3.5 1.0 1 0 0 1 1 1 1 CARMIL C-terminus Zip PF02535.22 ETN98392.1 - 0.68 9.1 8.7 0.75 8.9 8.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 ETN98392.1 - 1.3 7.9 4.9 1.4 7.8 4.9 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Podoplanin PF05808.11 ETN98392.1 - 1.4 9.0 5.2 1.6 8.8 5.2 1.2 1 0 0 1 1 1 0 Podoplanin Presenilin PF01080.17 ETN98392.1 - 1.6 7.4 10.3 1.8 7.3 10.3 1.0 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 ETN98392.1 - 1.7 8.7 8.2 2 8.4 8.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Menin PF05053.13 ETN98392.1 - 1.7 6.9 8.9 1.9 6.8 8.9 1.0 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 ETN98392.1 - 3.2 6.2 11.5 3.4 6.1 11.5 1.0 1 0 0 1 1 1 0 Macoilin family HCO3_cotransp PF00955.21 ETN98392.1 - 5.1 5.8 6.6 5.6 5.7 6.6 1.0 1 0 0 1 1 1 0 HCO3- transporter family ALMT PF11744.8 ETN98392.1 - 9.6 4.9 10.3 10 4.8 10.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Comm PF15957.5 ETN98394.1 - 0.1 13.0 3.3 0.12 12.7 2.9 1.5 1 1 0 1 1 1 0 Commissureless Rib_recp_KP_reg PF05104.12 ETN98394.1 - 9 7.3 9.7 0.6 11.1 5.0 1.4 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Yop-YscD_cpl PF16697.5 ETN98395.1 - 5e-06 26.7 0.0 9.2e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 ETN98395.1 - 7.8e-06 26.1 0.1 1.8e-05 25.0 0.1 1.6 1 0 0 1 1 1 1 FHA domain WD40 PF00400.32 ETN98396.1 - 4.9e-09 36.7 0.1 0.00044 21.0 0.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98396.1 - 0.00028 21.1 0.0 0.00034 20.9 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain SF3A3 PF16837.5 ETN98397.1 - 0.0039 17.7 0.7 5.4 7.6 0.0 3.1 2 2 1 3 3 3 2 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 HBB PF06777.11 ETN98397.1 - 0.044 13.5 0.2 0.08 12.6 0.2 1.4 1 1 0 1 1 1 0 Helical and beta-bridge domain PABP PF00658.18 ETN98398.1 - 0.04 14.1 1.3 0.063 13.5 0.1 2.0 2 1 0 2 2 2 0 Poly-adenylate binding protein, unique domain WD40 PF00400.32 ETN98399.1 - 1.1e-42 143.1 31.0 8.6e-07 29.6 0.1 7.9 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98399.1 - 2.7e-13 50.0 4.4 0.01 16.1 0.0 5.6 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98399.1 - 1.2e-10 40.7 6.7 0.011 14.4 0.4 5.2 3 1 2 5 5 5 4 Nucleoporin Nup120/160 TraC PF07820.12 ETN98400.1 - 0.0097 16.2 0.2 0.022 15.1 0.0 1.6 2 0 0 2 2 2 1 TraC-like protein DUF2802 PF10975.8 ETN98403.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) DUF4710 PF15828.5 ETN98403.1 - 3.7 7.7 9.3 0.55 10.4 5.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) TPR_12 PF13424.6 ETN98404.1 - 6.9e-38 128.8 9.5 2.2e-18 66.3 0.9 2.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98404.1 - 2.2e-20 71.8 5.2 2.4e-08 33.6 0.1 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98404.1 - 8e-18 63.4 12.2 3.9e-09 35.9 0.5 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98404.1 - 4.2e-17 60.8 2.7 9.4e-08 31.6 0.1 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98404.1 - 1.5e-10 40.3 8.1 5.8e-05 22.9 0.8 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98404.1 - 2.9e-10 39.5 8.8 6.4e-07 29.1 0.4 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98404.1 - 3.2e-07 30.3 4.4 0.028 14.8 0.0 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN98404.1 - 7.5e-05 22.7 5.0 0.028 14.5 0.3 2.2 2 0 0 2 2 2 2 Fis1 C-terminal tetratricopeptide repeat PPR PF01535.20 ETN98404.1 - 0.00036 20.6 0.3 0.11 12.8 0.0 2.7 2 1 0 2 2 2 1 PPR repeat HTH_Bact PF18768.1 ETN98404.1 - 0.0005 19.6 0.3 2.9 7.6 0.1 3.5 2 1 1 3 3 3 2 Helix-turn-helix bacterial domain DUF5113 PF17140.4 ETN98404.1 - 0.00055 19.8 3.8 0.13 12.1 0.6 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETN98404.1 - 0.001 18.7 12.9 0.23 11.2 0.4 4.2 3 2 1 4 4 4 2 TPR repeat MIT PF04212.18 ETN98404.1 - 0.0015 18.6 2.8 0.19 11.8 0.3 2.2 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETN98404.1 - 0.0023 18.5 0.1 1 10.1 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat SPO22 PF08631.10 ETN98404.1 - 0.0073 15.8 0.7 0.067 12.7 0.7 1.9 1 1 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 ETN98404.1 - 0.03 15.1 0.0 13 6.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Cohesin_load PF10345.9 ETN98404.1 - 0.057 11.9 1.5 0.93 7.9 0.4 2.0 1 1 1 2 2 2 0 Cohesin loading factor Sel1 PF08238.12 ETN98404.1 - 0.082 13.6 2.9 13 6.6 0.1 2.9 2 1 0 2 2 2 0 Sel1 repeat TPR_MalT PF17874.1 ETN98404.1 - 0.096 12.0 0.0 0.11 11.8 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region TPR_16 PF13432.6 ETN98404.1 - 0.11 13.2 0.0 11 6.8 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat 4PPT_N PF17837.1 ETN98405.1 - 0.014 15.5 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain EFG_C PF00679.24 ETN98409.1 - 1e-21 76.7 0.0 1.6e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 ETN98409.1 - 9.7e-19 67.3 0.0 1.4e-18 66.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor G, domain IV Kelch_6 PF13964.6 ETN98410.1 - 5e-06 26.6 1.3 0.027 14.8 0.2 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETN98410.1 - 4.2e-05 23.0 0.5 0.21 11.2 0.1 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETN98410.1 - 4.9e-05 23.2 3.7 0.028 14.4 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETN98410.1 - 6.6e-05 22.8 0.2 0.45 10.6 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN98410.1 - 0.00059 19.7 0.3 1.1 9.3 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Neur_chan_memb PF02932.16 ETN98412.1 - 0.0021 18.2 5.6 0.0027 17.8 5.6 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF929 PF06053.11 ETN98412.1 - 0.045 13.1 1.4 0.074 12.3 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF929) DUF4834 PF16118.5 ETN98412.1 - 0.046 14.7 5.4 0.046 14.7 5.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) PspB PF06667.12 ETN98412.1 - 0.05 13.7 1.3 0.094 12.8 1.3 1.5 1 0 0 1 1 1 0 Phage shock protein B DUF4381 PF14316.6 ETN98412.1 - 0.058 13.6 0.1 0.1 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Cadherin_C_2 PF16492.5 ETN98412.1 - 0.18 12.5 2.4 0.72 10.6 2.4 2.2 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal WBP-1 PF11669.8 ETN98412.1 - 0.23 12.1 5.8 0.18 12.4 1.4 2.2 2 0 0 2 2 2 0 WW domain-binding protein 1 RCR PF12273.8 ETN98412.1 - 0.45 11.2 5.8 0.85 10.3 5.8 1.5 1 1 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red MFS_Mycoplasma PF07672.13 ETN98412.1 - 0.62 9.3 5.2 1.1 8.4 5.2 1.4 1 0 0 1 1 1 0 Mycoplasma MFS transporter MscS_TM PF12794.7 ETN98412.1 - 1.1 8.1 3.0 1.8 7.4 3.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 SCFA_trans PF02667.14 ETN98412.1 - 1.2 8.0 5.0 1.6 7.6 5.0 1.1 1 0 0 1 1 1 0 Short chain fatty acid transporter PRC2_HTH_1 PF18118.1 ETN98412.1 - 1.4 9.7 10.9 7.2 7.5 6.8 2.2 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Eapp_C PF10238.9 ETN98412.1 - 1.8 8.7 12.8 3.8 7.6 7.5 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein 60KD_IMP PF02096.20 ETN98412.1 - 1.8 8.4 10.8 2.4 8.0 10.8 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein EphA2_TM PF14575.6 ETN98412.1 - 1.9 9.4 12.5 37 5.3 12.5 2.5 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Tmemb_9 PF05434.11 ETN98412.1 - 2 8.3 12.9 9.2 6.1 0.3 2.2 2 0 0 2 2 2 0 TMEM9 Baculo_11_kDa PF06143.11 ETN98412.1 - 5 6.8 9.0 0.4 10.3 3.6 2.1 2 0 0 2 2 2 0 Baculovirus 11 kDa family Protocadherin PF08374.11 ETN98412.1 - 5 7.0 16.1 0.075 13.0 2.8 2.2 1 1 0 2 2 2 0 Protocadherin Afi1 PF07792.12 ETN98412.1 - 7.3 7.1 11.4 2.7 8.5 0.4 2.3 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking OSTbeta PF15048.6 ETN98412.1 - 9.3 6.4 12.3 0.52 10.5 1.7 2.2 2 0 0 2 2 2 0 Organic solute transporter subunit beta protein CLN3 PF02487.17 ETN98412.1 - 9.8 5.1 8.6 2.6 7.0 0.4 2.0 2 0 0 2 2 2 0 CLN3 protein ERF PF04404.12 ETN98414.1 - 0.025 14.4 6.5 0.077 12.9 6.0 1.8 2 0 0 2 2 2 0 ERF superfamily DUF4338 PF14236.6 ETN98414.1 - 0.19 11.0 0.7 0.25 10.6 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4338) Rpn3_C PF08375.11 ETN98415.1 - 0.057 13.9 1.1 0.057 13.9 1.1 2.1 1 1 1 2 2 2 0 Proteasome regulatory subunit C-terminal Dala_Dala_lig_N PF01820.21 ETN98416.1 - 0.034 14.6 0.0 0.066 13.7 0.0 1.6 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus Condensin2nSMC PF12422.8 ETN98416.1 - 0.087 13.0 0.1 0.088 13.0 0.1 1.1 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit TPR_2 PF07719.17 ETN98418.1 - 1.8e-05 24.5 0.4 0.42 10.8 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98418.1 - 0.00015 21.4 0.4 0.33 10.8 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETN98418.1 - 0.0059 16.9 5.9 0.49 10.7 0.5 2.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98418.1 - 0.0099 16.6 2.1 0.41 11.6 0.2 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat Virul_Fac PF10139.9 ETN98418.1 - 0.024 12.9 0.2 0.028 12.7 0.2 1.0 1 0 0 1 1 1 0 Putative bacterial virulence factor TPR_15 PF13429.6 ETN98418.1 - 0.039 13.1 0.9 0.14 11.4 0.1 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98418.1 - 0.042 14.1 0.2 17 5.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN98418.1 - 0.043 13.9 0.8 0.094 12.8 0.8 1.6 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat GP24_25 PF17388.2 ETN98418.1 - 0.071 13.1 0.1 2.6 8.0 0.0 2.6 2 1 1 3 3 3 0 Tail assembly gene products 24 & 25 TPR_19 PF14559.6 ETN98418.1 - 0.26 11.8 3.7 0.41 11.2 1.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat CagY_M PF07337.11 ETN98419.1 - 0.65 9.7 5.5 0.66 9.6 2.4 2.3 2 0 0 2 2 2 0 DC-EC Repeat Cation_ATPase_C PF00689.21 ETN98421.1 - 3.4e-11 43.2 0.1 6.6e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus HSCB_C PF07743.13 ETN98423.1 - 0.016 15.7 0.5 0.026 15.0 0.5 1.3 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain AKNA PF12443.8 ETN98423.1 - 0.19 12.4 0.3 0.61 10.8 0.1 1.8 1 1 1 2 2 2 0 AT-hook-containing transcription factor Peptidase_C14 PF00656.22 ETN98424.1 - 0.001 19.1 0.0 0.0011 18.9 0.0 1.0 1 0 0 1 1 1 1 Caspase domain H2TH PF06831.14 ETN98425.1 - 0.12 12.3 0.0 0.28 11.2 0.0 1.8 1 1 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain Sod_Ni PF09055.11 ETN98425.1 - 0.14 12.7 1.8 0.39 11.3 0.1 2.4 1 1 2 3 3 3 0 Nickel-containing superoxide dismutase DUF5381 PF17353.2 ETN98426.1 - 0.015 15.0 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5381) Med19 PF10278.9 ETN98427.1 - 7.1 6.5 11.2 10 6.0 11.2 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 WD40 PF00400.32 ETN98428.1 - 9.9e-09 35.7 4.7 1.3e-06 29.0 0.4 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat CEP63 PF17045.5 ETN98428.1 - 0.0013 18.7 39.5 0.022 14.6 21.2 2.1 1 1 1 2 2 2 2 Centrosomal protein of 63 kDa Filament PF00038.21 ETN98428.1 - 0.0041 16.7 18.8 0.0041 16.7 18.8 2.1 1 1 1 2 2 2 1 Intermediate filament protein ANAPC4_WD40 PF12894.7 ETN98428.1 - 0.0083 16.4 0.6 0.024 14.9 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain HrpB7 PF09486.10 ETN98428.1 - 0.01 16.3 10.9 0.01 16.3 10.9 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) FAM76 PF16046.5 ETN98428.1 - 0.012 15.0 44.5 0.39 10.0 8.4 3.9 1 1 2 3 3 3 0 FAM76 protein Spc7 PF08317.11 ETN98428.1 - 0.013 14.4 44.4 0.023 13.6 26.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Nsp1_C PF05064.13 ETN98428.1 - 0.014 15.2 22.3 0.014 15.2 22.3 2.7 2 1 1 3 3 3 0 Nsp1-like C-terminal region DUF4200 PF13863.6 ETN98428.1 - 0.015 15.7 24.8 0.015 15.7 24.8 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) CC2-LZ PF16516.5 ETN98428.1 - 0.079 13.3 41.1 0.052 13.9 9.8 3.3 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF5631 PF18645.1 ETN98428.1 - 0.17 12.3 1.1 5.5 7.4 0.1 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5631) BRE1 PF08647.11 ETN98428.1 - 0.21 11.7 47.3 0.037 14.1 21.2 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase AAA_13 PF13166.6 ETN98428.1 - 0.23 10.1 38.9 0.094 11.3 36.7 1.4 1 1 0 1 1 1 0 AAA domain Sugarporin_N PF11471.8 ETN98428.1 - 0.36 10.8 12.7 0.72 9.9 2.0 3.4 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension DUF4618 PF15397.6 ETN98428.1 - 0.6 9.5 43.3 0.92 8.9 29.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) ATG16 PF08614.11 ETN98428.1 - 0.68 10.1 38.3 0.48 10.6 21.0 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spc24 PF08286.11 ETN98428.1 - 1 9.7 44.0 0.15 12.3 10.8 3.3 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Fez1 PF06818.15 ETN98428.1 - 1.1 9.7 35.3 3.6 8.0 21.3 2.1 1 1 1 2 2 2 0 Fez1 Cast PF10174.9 ETN98428.1 - 1.3 7.2 41.1 12 4.0 41.1 1.9 1 1 0 1 1 1 0 RIM-binding protein of the cytomatrix active zone OmpH PF03938.14 ETN98428.1 - 1.3 9.3 51.9 0.079 13.3 21.5 2.9 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) DUF641 PF04859.12 ETN98428.1 - 1.4 9.3 35.1 1.6 9.1 12.9 3.1 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) Sec2p PF06428.11 ETN98428.1 - 1.7 8.6 45.3 0.34 10.9 10.2 3.3 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p ERM PF00769.19 ETN98428.1 - 1.8 8.3 35.9 2.6 7.8 25.5 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family RasGAP_C PF03836.15 ETN98428.1 - 2.1 8.5 44.3 0.23 11.6 22.3 3.5 1 1 2 3 3 3 0 RasGAP C-terminus Fib_alpha PF08702.10 ETN98428.1 - 2.9 8.1 44.2 0.42 10.8 26.1 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF812 PF05667.11 ETN98428.1 - 3.5 6.4 42.5 5.6 5.7 42.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Prefoldin_2 PF01920.20 ETN98428.1 - 3.7 7.6 52.7 0.33 10.9 9.4 4.3 2 1 2 4 4 4 0 Prefoldin subunit GvpK PF05121.12 ETN98428.1 - 4 7.5 20.2 0.38 10.8 2.5 3.2 1 1 1 3 3 3 0 Gas vesicle protein K FliJ PF02050.16 ETN98428.1 - 4.2 7.6 37.9 3.6 7.8 26.2 2.4 1 1 0 2 2 2 0 Flagellar FliJ protein Swi5 PF07061.11 ETN98428.1 - 5 7.3 39.5 0.15 12.1 6.8 3.8 1 1 2 3 3 3 0 Swi5 DUF16 PF01519.16 ETN98428.1 - 6.3 7.3 47.1 1.2 9.7 13.6 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 DASH_Hsk3 PF08227.11 ETN98428.1 - 6.7 7.2 13.8 1.5 9.2 5.1 2.6 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Golgin_A5 PF09787.9 ETN98428.1 - 7.3 6.0 43.8 4.7 6.6 17.8 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Jnk-SapK_ap_N PF09744.9 ETN98428.1 - 8.1 6.7 42.4 2.7 8.2 24.8 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 ETN98428.1 - 10 5.4 33.3 10 5.3 23.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Flag1_repress PF03614.13 ETN98430.1 - 0.0032 17.3 0.5 0.0047 16.7 0.5 1.4 1 0 0 1 1 1 1 Repressor of phase-1 flagellin RICTOR_M PF14666.6 ETN98430.1 - 0.065 13.0 0.1 0.16 11.7 0.0 1.7 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, middle domain WD40 PF00400.32 ETN98431.1 - 2.6e-40 135.6 15.5 2.7e-07 31.2 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98431.1 - 1.2e-15 57.5 1.1 0.0024 18.1 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98431.1 - 3.3e-07 29.6 0.1 0.28 10.1 0.0 4.1 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 ETN98431.1 - 4e-06 26.1 0.1 0.00064 18.9 0.0 1.6 1 1 1 2 2 2 2 Coatomer WD associated region WD40_like PF17005.5 ETN98431.1 - 9.9e-06 25.1 3.5 0.0048 16.3 0.5 2.9 2 1 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETN98431.1 - 2.1e-05 24.3 8.4 0.37 10.8 0.0 4.1 5 1 1 6 6 6 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETN98431.1 - 0.00039 19.1 0.2 0.021 13.4 0.1 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETN98431.1 - 0.00089 18.3 4.0 1.4 7.8 0.7 3.9 2 2 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ETN98431.1 - 0.0016 17.2 2.2 9.5 4.7 0.1 4.3 3 1 1 4 4 4 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETN98431.1 - 0.0086 16.2 0.1 2.8 8.1 0.0 3.5 3 1 1 5 5 5 1 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETN98431.1 - 0.02 13.8 0.0 0.093 11.6 0.0 1.9 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Proteasome_A_N PF10584.9 ETN98431.1 - 0.025 14.2 2.6 21 4.9 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF5137 PF17220.3 ETN98433.1 - 0.11 13.3 0.1 0.56 11.1 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF5137) PI3K_rbd PF00794.18 ETN98433.1 - 0.13 12.5 2.2 1.5 9.0 0.0 3.9 4 0 0 4 4 4 0 PI3-kinase family, ras-binding domain DUF2721 PF11026.8 ETN98435.1 - 0.026 14.4 0.9 0.026 14.4 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) AAA PF00004.29 ETN98436.1 - 7.5e-09 36.1 0.0 0.00076 19.9 0.0 2.8 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETN98436.1 - 2.1e-07 31.0 0.2 0.0001 22.3 0.0 3.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETN98436.1 - 4.5e-07 29.6 0.1 0.0012 18.5 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 ETN98436.1 - 1e-05 25.9 0.3 0.15 12.3 0.0 3.3 3 0 0 3 3 2 2 AAA domain RsgA_GTPase PF03193.16 ETN98436.1 - 4e-05 23.6 0.3 0.0072 16.2 0.0 2.9 2 1 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ETN98436.1 - 0.00017 22.0 0.1 0.013 15.9 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 ETN98436.1 - 0.00036 21.0 0.0 0.0014 19.1 0.0 2.0 1 0 0 1 1 1 1 ABC transporter AAA_8 PF12780.7 ETN98436.1 - 0.0044 16.4 0.0 0.013 14.8 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 TsaE PF02367.17 ETN98436.1 - 0.01 15.8 1.0 0.03 14.3 0.0 2.3 3 0 0 3 3 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 ETN98436.1 - 0.015 15.4 0.0 0.45 10.6 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain MCM PF00493.23 ETN98436.1 - 0.026 13.6 0.1 0.16 11.1 0.0 2.2 2 0 0 2 2 2 0 MCM P-loop domain PduV-EutP PF10662.9 ETN98436.1 - 0.029 14.1 0.2 0.11 12.2 0.1 2.1 2 0 0 2 2 1 0 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 ETN98436.1 - 0.035 13.3 0.0 0.092 11.9 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_14 PF13173.6 ETN98436.1 - 0.035 14.1 0.1 0.31 11.1 0.0 2.8 2 0 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETN98436.1 - 0.048 13.4 0.0 0.36 10.5 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 ETN98436.1 - 0.078 12.9 0.9 0.82 9.6 0.1 2.9 2 1 0 2 2 2 0 NACHT domain AAA_19 PF13245.6 ETN98436.1 - 0.089 13.1 0.1 1.5 9.2 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ETN98436.1 - 0.1 12.4 0.5 11 5.7 0.0 3.2 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Mg_chelatase PF01078.21 ETN98436.1 - 0.17 11.2 0.1 8.3 5.7 0.0 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ETN98436.1 - 0.18 11.5 0.4 1.1 9.0 0.0 2.5 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_30 PF13604.6 ETN98436.1 - 0.19 11.4 0.1 18 5.0 0.1 2.4 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETN98436.1 - 0.78 10.2 0.0 0.78 10.2 0.0 3.5 3 1 0 3 3 2 0 AAA domain MlrC_C PF07171.12 ETN98437.1 - 0.23 11.6 0.0 0.43 10.7 0.0 1.3 1 0 0 1 1 1 0 MlrC C-terminus TMF_DNA_bd PF12329.8 ETN98439.1 - 0.0001 22.2 62.5 0.04 13.9 13.8 4.1 1 1 3 4 4 4 4 TATA element modulatory factor 1 DNA binding DUF16 PF01519.16 ETN98439.1 - 0.0019 18.7 48.2 0.19 12.3 17.0 4.1 1 1 2 3 3 3 1 Protein of unknown function DUF16 CHASE3 PF05227.13 ETN98439.1 - 0.0025 17.7 21.6 0.57 10.1 4.1 4.0 1 1 2 3 3 3 2 CHASE3 domain BRE1 PF08647.11 ETN98439.1 - 0.0038 17.3 23.6 0.0038 17.3 23.6 2.3 1 1 1 2 2 2 1 BRE1 E3 ubiquitin ligase YkyA PF10368.9 ETN98439.1 - 0.0059 16.3 31.8 0.0059 16.3 31.8 2.1 1 1 1 2 2 2 1 Putative cell-wall binding lipoprotein SlyX PF04102.12 ETN98439.1 - 0.0077 16.8 31.8 0.19 12.4 6.8 4.0 1 1 2 3 3 3 2 SlyX Spectrin PF00435.21 ETN98439.1 - 0.016 15.7 37.0 0.57 10.7 11.3 3.1 1 1 2 3 3 3 0 Spectrin repeat Phage_GP20 PF06810.11 ETN98439.1 - 0.016 15.0 15.6 0.016 15.0 15.6 4.6 1 1 4 5 5 5 0 Phage minor structural protein GP20 KASH_CCD PF14662.6 ETN98439.1 - 0.017 15.0 50.5 0.77 9.6 20.9 2.8 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH SHE3 PF17078.5 ETN98439.1 - 0.026 14.3 43.4 0.0089 15.8 33.4 2.2 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 bZIP_Maf PF03131.17 ETN98439.1 - 0.053 14.0 38.3 1.8 9.1 2.6 4.5 1 1 4 5 5 5 0 bZIP Maf transcription factor APG6_N PF17675.1 ETN98439.1 - 0.054 14.0 50.9 0.81 10.2 24.1 3.1 1 1 2 3 3 3 0 Apg6 coiled-coil region DivIC PF04977.15 ETN98439.1 - 0.078 12.8 56.6 0.34 10.7 8.9 5.1 1 1 4 5 5 5 0 Septum formation initiator DUF2570 PF10828.8 ETN98439.1 - 0.14 12.0 37.4 0.61 9.9 5.9 4.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2570) Med9 PF07544.13 ETN98439.1 - 0.27 11.4 47.4 0.5 10.5 5.9 5.1 1 1 6 7 7 7 0 RNA polymerase II transcription mediator complex subunit 9 CorA PF01544.18 ETN98439.1 - 0.48 9.7 17.3 0.061 12.6 9.6 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein ADIP PF11559.8 ETN98439.1 - 0.52 10.4 47.6 3.9 7.5 13.5 2.9 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4446 PF14584.6 ETN98439.1 - 0.59 10.1 37.4 1.5 8.8 2.3 4.6 1 1 4 5 5 5 0 Protein of unknown function (DUF4446) DUF2935 PF11155.8 ETN98439.1 - 0.66 10.3 19.8 1.5 9.1 8.1 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF2935) MAD PF05557.13 ETN98439.1 - 1 7.6 47.4 2.3 6.5 47.4 1.5 1 1 0 1 1 1 0 Mitotic checkpoint protein Mod_r PF07200.13 ETN98439.1 - 1.1 9.4 47.7 0.26 11.4 13.7 2.9 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein TPR_MLP1_2 PF07926.12 ETN98439.1 - 1.2 9.2 48.3 0.039 14.0 28.1 3.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Leu_zip PF15294.6 ETN98439.1 - 1.3 8.5 44.4 0.26 10.8 25.2 2.1 1 1 1 2 2 2 0 Leucine zipper MCD PF05292.11 ETN98439.1 - 1.4 8.5 12.7 5 6.6 7.8 2.0 1 1 1 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain Fib_alpha PF08702.10 ETN98439.1 - 1.4 9.1 41.2 0.13 12.5 18.0 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family GAS PF13851.6 ETN98439.1 - 1.5 8.1 58.1 0.2 11.0 32.7 2.6 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding HOOK PF05622.12 ETN98439.1 - 3.2 5.8 48.6 3.4 5.7 11.1 2.1 1 1 1 2 2 2 0 HOOK protein Herpes_UL6 PF01763.16 ETN98439.1 - 7.1 5.0 37.0 1.8 7.0 2.6 3.5 1 1 2 3 3 3 0 Herpesvirus UL6 like zf-C4H2 PF10146.9 ETN98439.1 - 7.6 6.8 38.3 27 5.0 3.9 2.8 1 1 1 2 2 2 0 Zinc finger-containing protein BLOC1_2 PF10046.9 ETN98439.1 - 7.9 6.9 45.3 5.7 7.3 2.7 4.5 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1759 PF03564.15 ETN98439.1 - 8.1 6.4 22.4 1.6 8.6 2.5 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1759) RR_TM4-6 PF06459.12 ETN98440.1 - 1.2 8.9 21.0 1.4 8.7 21.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DNA_topoisoIV PF00521.20 ETN98441.1 - 0.00023 20.2 7.9 0.00023 20.2 7.9 1.9 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A DUF2232 PF09991.9 ETN98441.1 - 0.041 13.1 0.1 0.061 12.5 0.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) ABC2_membrane_3 PF12698.7 ETN98441.1 - 2.3 7.3 5.9 3 6.9 5.9 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3915 PF13054.6 ETN98441.1 - 3.3 7.7 12.8 0.64 10.0 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) CAC1F_C PF16885.5 ETN98441.1 - 5.9 6.4 13.0 8.4 5.9 13.0 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DNA_gyraseB PF00204.25 ETN98443.1 - 8.8e-16 57.9 5.0 8.8e-16 57.9 5.0 1.9 3 0 0 3 3 3 1 DNA gyrase B HATPase_c PF02518.26 ETN98443.1 - 7e-12 45.9 0.6 2.4e-11 44.1 0.1 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ETN98443.1 - 7.4e-08 32.6 0.0 7.4e-08 32.6 0.0 3.1 3 2 0 3 3 3 1 Toprim domain Kelch_4 PF13418.6 ETN98446.1 - 7.6e-08 32.2 0.0 0.002 18.1 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98446.1 - 2.1e-07 30.4 0.7 0.00047 19.7 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETN98446.1 - 1.1e-06 28.7 0.1 0.015 15.6 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETN98446.1 - 1.5e-05 24.8 0.1 0.0019 18.1 0.1 2.4 2 0 0 2 2 2 1 Kelch motif CDC45 PF02724.14 ETN98446.1 - 0.0018 16.6 2.4 0.002 16.5 2.4 1.1 1 0 0 1 1 1 1 CDC45-like protein Kelch_5 PF13854.6 ETN98446.1 - 0.0051 16.8 0.4 1 9.4 0.0 2.3 2 0 0 2 2 2 1 Kelch motif Astro_capsid_p PF12226.8 ETN98446.1 - 0.018 14.2 3.6 0.024 13.8 3.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Kelch_3 PF13415.6 ETN98446.1 - 0.064 13.6 0.1 31 5.0 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF4611 PF15387.6 ETN98446.1 - 0.13 12.5 12.2 0.21 11.8 12.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ETN98446.1 - 0.77 9.4 9.4 1.2 8.8 9.4 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETN98446.1 - 0.77 9.0 9.1 1.1 8.5 9.1 1.2 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.11 ETN98446.1 - 1.6 6.7 9.2 1.9 6.5 9.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.6 ETN98446.1 - 1.8 9.0 7.8 3.3 8.1 7.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WD40 PF00400.32 ETN98447.1 - 2.8e-13 50.1 0.4 6.4e-06 26.8 0.0 2.7 2 1 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98447.1 - 0.012 14.3 0.1 1.7 7.2 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Vps16_C PF04840.12 ETN98448.1 - 0.02 13.9 0.2 0.026 13.6 0.2 1.1 1 0 0 1 1 1 0 Vps16, C-terminal region EGF PF00008.27 ETN98448.1 - 0.02 15.2 8.4 0.02 15.2 8.4 2.5 2 0 0 2 2 2 0 EGF-like domain EGF_2 PF07974.13 ETN98448.1 - 0.029 14.7 11.7 0.029 14.7 11.7 2.1 2 0 0 2 2 2 0 EGF-like domain FTR1 PF03239.14 ETN98448.1 - 0.033 13.4 0.1 0.047 12.9 0.1 1.1 1 0 0 1 1 1 0 Iron permease FTR1 family Adeno_E3_CR2 PF02439.15 ETN98448.1 - 0.24 11.2 5.3 0.5 10.2 5.3 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 hEGF PF12661.7 ETN98448.1 - 1.2 9.9 17.7 1.5 9.6 8.7 2.9 3 0 0 3 3 3 0 Human growth factor-like EGF DUF645 PF04875.12 ETN98449.1 - 0.016 15.2 0.4 0.031 14.3 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF645 Nuc_H_symport PF03825.16 ETN98449.1 - 0.035 13.1 0.0 0.045 12.7 0.0 1.1 1 0 0 1 1 1 0 Nucleoside H+ symporter HetR_C PF18460.1 ETN98450.1 - 0.012 15.5 0.3 0.017 15.0 0.3 1.2 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain Striatin PF08232.12 ETN98450.1 - 0.057 14.0 9.9 0.076 13.6 9.9 1.2 1 0 0 1 1 1 0 Striatin family CDC45 PF02724.14 ETN98450.1 - 5 5.3 12.4 5.1 5.3 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Di19_C PF14571.6 ETN98450.1 - 6.2 7.4 10.0 9.7 6.8 10.0 1.5 1 1 0 1 1 1 0 Stress-induced protein Di19, C-terminal Golgin_A5 PF09787.9 ETN98451.1 - 0.0081 15.7 27.6 0.08 12.4 15.7 2.3 1 1 1 2 2 2 2 Golgin subfamily A member 5 DUF4201 PF13870.6 ETN98451.1 - 0.023 14.5 7.3 0.023 14.5 7.3 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF641 PF04859.12 ETN98451.1 - 0.031 14.6 19.0 0.092 13.1 3.0 2.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) GAS PF13851.6 ETN98451.1 - 0.11 11.9 28.2 0.17 11.2 22.0 2.5 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Med4 PF10018.9 ETN98451.1 - 0.44 10.2 20.7 0.11 12.2 8.3 2.6 1 1 2 3 3 3 0 Vitamin-D-receptor interacting Mediator subunit 4 Atg14 PF10186.9 ETN98451.1 - 1.1 8.3 16.9 13 4.8 15.0 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 bZIP_1 PF00170.21 ETN98451.1 - 1.1 9.4 15.6 2.2 8.4 3.5 3.8 2 1 1 3 3 3 0 bZIP transcription factor FlaC_arch PF05377.11 ETN98451.1 - 1.5 9.3 12.0 9.9 6.6 1.7 4.0 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) FliD_N PF02465.18 ETN98451.1 - 1.6 9.4 20.0 19 6.0 9.0 3.9 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TPR_MLP1_2 PF07926.12 ETN98451.1 - 2.2 8.4 28.6 0.46 10.6 24.1 2.2 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein NPV_P10 PF05531.12 ETN98451.1 - 2.7 8.5 14.6 4.2 7.9 0.3 4.1 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 ETN98451.1 - 2.9 7.9 18.7 0.084 12.9 2.0 3.1 2 1 2 4 4 4 0 Laminin Domain II Spc7 PF08317.11 ETN98451.1 - 3.4 6.5 29.0 0.41 9.5 18.6 2.4 1 1 2 3 3 3 0 Spc7 kinetochore protein DASH_Dam1 PF08653.10 ETN98451.1 - 3.7 7.4 6.9 4.1 7.3 0.3 3.4 4 1 0 4 4 3 0 DASH complex subunit Dam1 YabA PF06156.13 ETN98451.1 - 4.3 8.0 22.5 0.94 10.2 1.9 4.1 1 1 2 3 3 3 0 Initiation control protein YabA Lipoprotein_6 PF01441.19 ETN98451.1 - 4.6 7.2 15.8 0.13 12.3 1.0 3.4 2 1 2 4 4 4 0 Lipoprotein Exonuc_VII_L PF02601.15 ETN98451.1 - 4.7 6.7 21.2 41 3.6 1.3 2.2 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETN98451.1 - 5.1 7.2 14.9 1.3 9.1 6.2 3.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) eIF-4B PF06273.11 ETN98451.1 - 9.7 5.1 11.8 4 6.4 8.7 1.8 1 1 0 2 2 2 0 Plant specific eukaryotic initiation factor 4B Ion_trans PF00520.31 ETN98453.1 - 1.2e-12 47.6 31.9 1.2e-12 47.6 31.9 6.5 5 3 0 5 5 5 2 Ion transport protein DUF2615 PF11027.8 ETN98453.1 - 0.01 16.0 5.2 7.1 6.8 0.0 6.0 7 0 0 7 7 7 0 Protein of unknown function (DUF2615) SspB PF04386.13 ETN98453.1 - 0.031 14.2 0.1 0.11 12.4 0.1 1.9 1 0 0 1 1 1 0 Stringent starvation protein B PepSY_TM PF03929.16 ETN98453.1 - 0.083 12.5 0.0 0.73 9.5 0.0 2.4 2 0 0 2 2 2 0 PepSY-associated TM region EphA2_TM PF14575.6 ETN98453.1 - 0.3 12.0 10.2 1.8 9.5 1.6 5.6 4 1 0 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain Cpn60_TCP1 PF00118.24 ETN98455.1 - 4.1e-40 137.8 0.5 5.1e-40 137.5 0.5 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glyoxalase_3 PF13468.6 ETN98455.1 - 0.049 13.8 0.0 0.068 13.3 0.0 1.1 1 0 0 1 1 1 0 Glyoxalase-like domain ASFV_J13L PF05568.11 ETN98456.1 - 2.6e-05 24.1 1.0 3.6e-05 23.6 1.0 1.3 1 0 0 1 1 1 1 African swine fever virus J13L protein SpoIIIAH PF12685.7 ETN98456.1 - 3.2e-05 23.9 0.6 3.2e-05 23.9 0.6 1.3 2 0 0 2 2 2 1 SpoIIIAH-like protein DUF4834 PF16118.5 ETN98456.1 - 4.9e-05 24.2 2.7 4.9e-05 24.2 2.7 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 ETN98456.1 - 0.00033 20.8 9.2 0.00042 20.4 9.2 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal PIG-U PF06728.13 ETN98456.1 - 0.00038 19.6 1.9 0.00047 19.3 1.9 1.1 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U CBP_BcsG PF11658.8 ETN98456.1 - 0.0027 16.2 0.2 0.0027 16.2 0.2 1.1 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsG Tmemb_9 PF05434.11 ETN98456.1 - 0.0027 17.6 9.1 0.0039 17.1 8.9 1.5 1 1 0 1 1 1 1 TMEM9 DUF1700 PF08006.11 ETN98456.1 - 0.038 13.5 8.3 0.064 12.8 8.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) EOS1 PF12326.8 ETN98456.1 - 0.049 13.6 0.6 0.065 13.2 0.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein Shisa PF13908.6 ETN98456.1 - 0.39 10.9 4.6 0.73 10.0 4.6 1.6 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Cytomega_TRL10 PF06084.11 ETN98456.1 - 0.75 9.8 4.0 1.2 9.2 4.0 1.5 1 1 0 1 1 1 0 Cytomegalovirus TRL10 protein DUF2681 PF10883.8 ETN98456.1 - 8.3 6.9 14.6 38 4.8 14.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) zf-TRAF PF02176.18 ETN98457.1 - 0.00027 21.6 2.1 0.00027 21.6 2.1 2.9 2 1 1 3 3 3 1 TRAF-type zinc finger NRBF2 PF08961.10 ETN98457.1 - 0.027 14.1 0.4 0.039 13.6 0.4 1.4 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator GIT_CC PF16559.5 ETN98457.1 - 0.038 13.9 3.3 0.16 11.9 1.0 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 ETN98457.1 - 0.061 14.0 9.7 0.057 14.1 7.4 2.2 2 1 0 2 2 2 0 Initiation control protein YabA IF-2 PF11987.8 ETN98457.1 - 0.067 13.3 0.1 0.73 10.0 0.0 2.1 2 0 0 2 2 2 0 Translation-initiation factor 2 Herpes_BLRF2 PF05812.12 ETN98457.1 - 0.95 9.6 5.3 7.3 6.8 1.5 2.3 1 1 1 2 2 2 0 Herpesvirus BLRF2 protein AKAP7_RIRII_bdg PF10470.9 ETN98457.1 - 1.8 8.7 5.5 4.8 7.3 0.1 2.9 3 0 0 3 3 3 0 PKA-RI-RII subunit binding domain of A-kinase anchor protein DivIC PF04977.15 ETN98457.1 - 3.3 7.6 10.9 0.45 10.3 3.9 2.5 1 1 1 2 2 2 0 Septum formation initiator WD40 PF00400.32 ETN98458.1 - 9.7e-09 35.7 1.4 2e-08 34.8 0.7 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98458.1 - 0.074 13.4 0.0 0.22 11.9 0.0 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Tho2 PF11262.8 ETN98458.1 - 0.57 9.3 13.0 0.76 8.9 13.0 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Cbl_N2 PF02761.14 ETN98458.1 - 1.2 9.9 4.7 3.2 8.5 1.2 2.3 1 1 1 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain LRS4 PF10422.9 ETN98458.1 - 1.5 8.3 15.1 2.1 7.8 15.1 1.3 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 FtsX_ECD PF18075.1 ETN98458.1 - 2.5 8.8 10.7 8.8 7.0 3.2 2.3 1 1 1 2 2 2 0 FtsX extracellular domain PTPlike_phytase PF14566.6 ETN98458.1 - 7 6.7 7.3 34 4.5 7.4 1.9 1 1 0 1 1 1 0 Inositol hexakisphosphate U-box PF04564.15 ETN98459.1 - 8.3e-05 22.7 0.4 0.00022 21.3 0.4 1.7 2 0 0 2 2 2 1 U-box domain BLM_N PF16202.5 ETN98459.1 - 0.063 12.4 0.0 0.076 12.1 0.0 1.1 1 0 0 1 1 1 0 N-terminal region of Bloom syndrome protein HOOK PF05622.12 ETN98460.1 - 0.0013 17.0 21.5 0.0013 17.0 21.5 2.0 1 1 1 2 2 2 1 HOOK protein APG6_N PF17675.1 ETN98460.1 - 0.0081 16.7 14.2 0.0081 16.7 14.2 2.1 1 1 1 2 2 2 1 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 ETN98460.1 - 0.03 14.3 35.3 0.6 10.1 17.9 3.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 ETN98460.1 - 0.15 12.1 19.3 1 9.4 5.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ETN98460.1 - 0.15 10.9 40.1 0.15 10.9 20.5 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein FapA PF03961.13 ETN98460.1 - 0.21 10.2 27.2 0.021 13.4 9.5 2.5 1 1 2 3 3 3 0 Flagellar Assembly Protein A ATG16 PF08614.11 ETN98460.1 - 0.8 9.9 40.7 0.21 11.8 18.7 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) PI3K_P85_iSH2 PF16454.5 ETN98460.1 - 1.4 8.5 31.1 19 4.8 30.0 2.8 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3584 PF12128.8 ETN98460.1 - 3.1 5.2 35.5 24 2.2 35.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Golgin_A5 PF09787.9 ETN98460.1 - 4.2 6.7 36.4 0.78 9.1 13.2 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF4164 PF13747.6 ETN98460.1 - 5.9 7.2 19.9 0.13 12.6 5.6 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF4105 PF13387.6 ETN98460.1 - 6.1 6.4 9.2 0.46 10.1 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4105) Ank_2 PF12796.7 ETN98461.1 - 4.2e-09 36.9 0.0 0.00052 20.6 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETN98461.1 - 6.7e-08 32.9 0.0 0.00092 19.7 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETN98461.1 - 2.7e-06 27.6 0.0 0.0017 18.7 0.0 3.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETN98461.1 - 2.3e-05 24.6 0.0 0.025 14.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETN98461.1 - 8.2e-05 22.7 0.0 0.003 17.9 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Cdh1_DBD_1 PF18196.1 ETN98461.1 - 0.18 12.1 2.4 0.21 11.9 0.4 1.9 2 0 0 2 2 2 0 Chromodomain helicase DNA-binding domain 1 Lebercilin PF15619.6 ETN98463.1 - 0.0047 16.6 18.4 0.025 14.3 4.6 2.8 1 1 1 2 2 2 2 Ciliary protein causing Leber congenital amaurosis disease LemA PF04011.12 ETN98463.1 - 0.01 15.7 0.4 0.01 15.7 0.4 1.7 2 0 0 2 2 2 0 LemA family Apt1 PF10351.9 ETN98463.1 - 0.015 14.1 7.9 0.025 13.5 4.1 1.9 1 1 1 2 2 2 0 Golgi-body localisation protein domain DNA_pol_lambd_f PF10391.9 ETN98463.1 - 0.032 14.0 0.7 2.5 8.0 0.0 2.9 3 0 0 3 3 3 0 Fingers domain of DNA polymerase lambda She9_MDM33 PF05546.11 ETN98463.1 - 0.073 12.9 10.4 0.26 11.0 0.7 2.3 2 1 0 2 2 2 0 She9 / Mdm33 family Bacillus_HBL PF05791.11 ETN98463.1 - 0.093 12.6 7.6 0.025 14.4 2.4 1.9 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Glutaredoxin2_C PF04399.13 ETN98463.1 - 0.12 12.2 5.1 3.9 7.3 0.1 3.0 1 1 2 3 3 3 0 Glutaredoxin 2, C terminal domain DUF5082 PF16888.5 ETN98463.1 - 0.12 12.6 13.5 2.3 8.5 6.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) CorA PF01544.18 ETN98463.1 - 0.18 11.1 4.5 1.6 8.0 0.4 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein AAA_lid_9 PF17871.1 ETN98463.1 - 1.1 9.2 9.1 1.4 8.9 0.3 2.8 2 1 0 2 2 2 0 AAA lid domain WXG100 PF06013.12 ETN98463.1 - 1.2 9.4 5.0 23 5.3 0.1 3.2 3 1 1 4 4 4 0 Proteins of 100 residues with WXG Exonuc_VII_L PF02601.15 ETN98463.1 - 1.6 8.3 7.0 2.1 7.8 7.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 ETN98463.1 - 2.5 6.9 18.1 0.076 11.9 7.9 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETN98463.1 - 3.3 7.8 9.9 12 6.0 0.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 ETN98463.1 - 5.5 7.2 17.9 1 9.6 8.2 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 FapA PF03961.13 ETN98463.1 - 9.8 4.6 16.0 1.5 7.4 7.7 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A OmpH PF03938.14 ETN98464.1 - 0.0026 18.1 10.9 0.0026 18.1 10.9 4.9 4 2 0 5 5 5 2 Outer membrane protein (OmpH-like) Spc7 PF08317.11 ETN98464.1 - 0.0065 15.4 6.7 0.0065 15.4 6.7 4.4 3 2 2 5 5 5 2 Spc7 kinetochore protein Med13_N PF11597.8 ETN98464.1 - 0.055 12.8 0.2 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 Mediator complex subunit 13 N-terminal F-box_4 PF15966.5 ETN98464.1 - 0.17 11.8 1.6 1.1 9.1 0.1 2.5 2 0 0 2 2 2 0 F-box DUF5617 PF18493.1 ETN98464.1 - 0.31 11.2 0.1 0.31 11.2 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF5617) DUF5601 PF18151.1 ETN98464.1 - 0.54 10.6 7.7 0.37 11.1 0.3 4.1 3 1 0 3 3 3 0 Domain of unknown function (DUF5601) Lebercilin PF15619.6 ETN98464.1 - 5.5 6.6 48.0 0.22 11.2 9.3 4.8 3 1 1 4 4 4 0 Ciliary protein causing Leber congenital amaurosis disease DUF501 PF04417.12 ETN98464.1 - 8.5 6.2 9.3 19 5.0 2.1 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF501) SR-25 PF10500.9 ETN98465.1 - 1.6 8.3 13.8 1.7 8.2 13.8 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Tsc35 PF15079.6 ETN98469.1 - 0.018 14.6 0.3 0.019 14.6 0.3 1.0 1 0 0 1 1 1 0 Testis-specific protein 35 ACP_PD PF04336.12 ETN98470.1 - 0.029 14.8 1.1 0.029 14.8 1.1 2.4 2 1 1 3 3 3 0 Acyl carrier protein phosphodiesterase DUF1053 PF06327.14 ETN98470.1 - 0.071 13.7 4.9 0.23 12.0 4.9 1.9 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1053) Flavokinase PF01687.17 ETN98470.1 - 0.077 13.3 0.0 0.98 9.8 0.0 2.4 2 0 0 2 2 2 0 Riboflavin kinase Glyco_hydro_67N PF03648.14 ETN98470.1 - 0.12 12.7 2.8 0.35 11.2 2.8 1.8 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus NgoMIV_restric PF09015.10 ETN98470.1 - 0.43 9.6 4.1 0.28 10.3 1.6 1.8 2 0 0 2 2 2 0 NgoMIV restriction enzyme FlxA PF14282.6 ETN98470.1 - 0.92 9.5 25.0 3.4 7.7 25.0 2.0 1 0 0 1 1 1 0 FlxA-like protein PP2C_C PF07830.13 ETN98470.1 - 1.1 9.8 5.4 1.2 9.6 3.4 2.1 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain DUF2228 PF10228.9 ETN98470.1 - 1.2 8.8 9.6 0.051 13.3 3.2 2.0 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2228) DUF2935 PF11155.8 ETN98470.1 - 3.3 8.0 9.3 12 6.3 7.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) Med4 PF10018.9 ETN98470.1 - 6.5 6.4 16.5 1.3 8.7 4.2 2.3 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 Peptidase_C14 PF00656.22 ETN98471.1 - 2.4e-08 34.3 0.1 3.4e-08 33.8 0.1 1.3 1 1 0 1 1 1 1 Caspase domain EPOP PF15223.6 ETN98472.1 - 0.0083 15.5 0.1 0.0083 15.5 0.1 1.1 1 0 0 1 1 1 1 Elongin BC and Polycomb repressive complex 2-associated protein RecQ_Zn_bind PF16124.5 ETN98473.1 - 0.045 14.5 2.1 0.087 13.6 2.0 1.6 1 1 0 1 1 1 0 RecQ zinc-binding NDUFB10 PF10249.9 ETN98473.1 - 0.098 13.2 0.4 0.11 13.0 0.4 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit 10 Fimbrial_CS1 PF04449.12 ETN98474.1 - 0.022 14.9 0.6 0.059 13.5 0.0 1.9 3 0 0 3 3 3 0 CS1 type fimbrial major subunit SAP30_Sin3_bdg PF13867.6 ETN98475.1 - 0.066 13.6 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 Gly-zipper_Omp PF13488.6 ETN98476.1 - 0.0034 17.3 25.1 0.027 14.4 24.4 2.1 1 1 1 2 2 2 2 Glycine zipper Gly-zipper_YMGG PF13441.6 ETN98476.1 - 0.004 16.9 29.1 0.028 14.2 29.1 2.0 1 1 1 2 2 2 2 YMGG-like Gly-zipper DUF937 PF06078.11 ETN98476.1 - 0.05 14.2 0.7 0.085 13.5 0.7 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF937) Rick_17kDa_Anti PF05433.15 ETN98476.1 - 0.061 13.2 28.4 0.17 11.8 28.4 1.7 1 1 0 1 1 1 0 Glycine zipper 2TM domain SLATT_1 PF18181.1 ETN98476.1 - 0.069 13.1 2.7 0.77 9.7 0.4 2.4 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 1 Gly-zipper_OmpA PF13436.6 ETN98476.1 - 0.07 12.9 28.6 0.086 12.6 9.4 2.2 1 1 1 2 2 2 0 Glycine-zipper domain EMP24_GP25L PF01105.24 ETN98476.1 - 0.078 12.9 6.4 0.16 11.9 6.4 1.6 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD SRA1 PF07304.11 ETN98476.1 - 0.084 12.7 1.0 0.14 11.9 0.8 1.5 1 1 0 1 1 1 0 Steroid receptor RNA activator (SRA1) APG6_N PF17675.1 ETN98476.1 - 0.1 13.1 7.5 0.18 12.3 7.5 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region TraT PF05818.12 ETN98476.1 - 0.29 10.8 8.1 0.67 9.6 8.1 1.8 1 1 0 1 1 1 0 Enterobacterial TraT complement resistance protein DUF919 PF06034.11 ETN98476.1 - 0.68 9.8 12.1 0.36 10.7 2.8 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF3482 PF11981.8 ETN98476.1 - 0.73 9.2 5.4 1.8 7.9 5.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Seryl_tRNA_N PF02403.22 ETN98476.1 - 1.2 9.3 13.9 2.2 8.5 7.6 2.6 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Bacteriocin_IIc PF10439.9 ETN98476.1 - 5.1 7.3 24.4 4.8e+02 1.0 24.4 2.3 1 1 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide FliD_N PF02465.18 ETN98476.1 - 7.9 7.2 8.6 15 6.4 3.6 3.1 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF3744 PF12558.8 ETN98477.1 - 0.034 14.9 0.1 0.037 14.8 0.1 1.2 1 0 0 1 1 1 0 ATP-binding cassette cobalt transporter Peptidase_C14 PF00656.22 ETN98478.1 - 1e-08 35.5 0.5 2.1e-08 34.4 0.5 1.5 1 0 0 1 1 1 1 Caspase domain SAM_1 PF00536.30 ETN98479.1 - 1.1e-09 38.6 0.1 1.9e-09 37.8 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN98479.1 - 1.2e-08 34.9 0.1 2.1e-08 34.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF4485 PF14846.6 ETN98480.1 - 0.027 14.5 0.1 0.037 14.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) Polbeta PF18765.1 ETN98480.1 - 0.061 13.4 1.8 0.068 13.3 1.1 1.4 1 1 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase WW PF00397.26 ETN98481.1 - 0.28 11.3 5.0 0.74 10.0 5.0 1.7 1 0 0 1 1 1 0 WW domain NifQ PF04891.12 ETN98482.1 - 0.015 15.7 0.4 0.061 13.7 0.1 2.2 2 0 0 2 2 2 0 NifQ HDV_ag PF01517.18 ETN98483.1 - 0.015 15.1 0.3 0.015 15.1 0.3 2.2 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen Myc_N PF01056.18 ETN98483.1 - 0.28 11.0 16.7 0.015 15.3 9.3 2.2 1 1 2 3 3 3 0 Myc amino-terminal region Nnf1 PF03980.14 ETN98484.1 - 0.73 10.2 20.7 0.32 11.4 10.6 2.1 2 0 0 2 2 2 0 Nnf1 DASH_Hsk3 PF08227.11 ETN98484.1 - 0.76 10.2 5.0 2.3 8.6 5.0 1.9 1 0 0 1 1 1 0 DASH complex subunit Hsk3 like DUF4320 PF14208.6 ETN98484.1 - 1.1 9.4 5.1 0.26 11.4 0.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) GCN5L1 PF06320.13 ETN98484.1 - 1.9 8.7 13.9 2.3 8.4 0.3 2.3 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) KLRAQ PF10205.9 ETN98484.1 - 4.9 7.4 18.8 0.45 10.8 8.8 2.6 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein NAM-associated PF14303.6 ETN98484.1 - 5.1 7.8 16.8 0.23 12.2 9.9 1.8 1 1 1 2 2 2 0 No apical meristem-associated C-terminal domain ERM PF00769.19 ETN98484.1 - 8.5 6.1 26.3 57 3.4 26.3 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family S-AdoMet_synt_C PF02773.16 ETN98485.1 - 1.8e-69 232.1 0.0 3.2e-69 231.2 0.0 1.4 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ETN98485.1 - 1.7e-45 154.1 0.1 3.4e-45 153.2 0.1 1.5 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ETN98485.1 - 4.4e-41 139.6 0.2 9.3e-41 138.5 0.2 1.6 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain DUF2312 PF10073.9 ETN98485.1 - 0.14 11.8 0.1 0.36 10.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) ATP13 PF12921.7 ETN98486.1 - 0.034 14.0 0.1 0.056 13.3 0.1 1.4 1 0 0 1 1 1 0 Mitochondrial ATPase expression Exo_endo_phos PF03372.23 ETN98487.1 - 0.02 14.4 0.1 0.024 14.1 0.1 1.3 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family CDC45 PF02724.14 ETN98489.1 - 0.19 10.0 10.6 0.21 9.9 10.6 1.0 1 0 0 1 1 1 0 CDC45-like protein NARP1 PF12569.8 ETN98489.1 - 1 8.2 12.7 1.1 8.0 12.7 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.17 ETN98489.1 - 8.7 5.0 9.1 9 4.9 9.1 1.0 1 0 0 1 1 1 0 Presenilin Pentapeptide PF00805.22 ETN98490.1 - 0.016 14.8 0.3 1.3 8.8 0.0 2.4 2 0 0 2 2 2 0 Pentapeptide repeats (8 copies) SNX17_FERM_C PF18116.1 ETN98491.1 - 0.076 13.1 0.0 0.093 12.8 0.0 1.1 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain WD40 PF00400.32 ETN98492.1 - 1.1e-27 95.7 6.0 1.1e-06 29.2 0.4 5.2 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98492.1 - 3.7e-11 43.2 0.8 0.0078 16.5 0.0 4.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98492.1 - 2e-08 33.4 0.8 0.12 11.0 0.1 3.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETN98492.1 - 6.8e-06 26.7 3.4 6.8e-06 26.7 3.4 2.8 1 1 1 2 2 2 1 TRAF-type zinc finger WD40_like PF17005.5 ETN98492.1 - 0.00035 20.0 14.1 0.015 14.6 0.2 4.9 3 3 1 4 4 4 3 WD40-like domain F5_F8_type_C PF00754.25 ETN98493.1 - 0.00023 21.3 0.0 0.00033 20.8 0.0 1.3 1 0 0 1 1 1 1 F5/8 type C domain Sad1_UNC PF07738.13 ETN98493.1 - 0.16 12.0 0.1 21 5.1 0.0 2.2 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal Kelch_1 PF01344.25 ETN98494.1 - 5.7e-07 29.0 0.2 0.00072 19.1 0.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETN98494.1 - 2.7e-05 24.1 0.1 0.061 13.3 0.0 2.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN98494.1 - 8.4e-05 22.7 0.3 0.11 12.8 0.0 3.4 2 1 1 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETN98494.1 - 0.0021 18.0 0.8 0.083 12.9 0.0 3.2 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETN98494.1 - 0.043 13.8 1.0 10 6.2 0.0 3.3 4 0 0 4 4 4 0 Kelch motif NOA36 PF06524.12 ETN98496.1 - 0.024 14.0 4.1 0.041 13.2 4.1 1.3 1 0 0 1 1 1 0 NOA36 protein WD40 PF00400.32 ETN98497.1 - 1.3e-10 41.7 1.8 0.0023 18.7 0.0 5.6 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98497.1 - 3.4e-08 33.7 0.0 0.4 11.0 0.0 5.4 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETN98497.1 - 3.4e-07 30.0 0.7 4.4 7.4 0.0 5.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETN98497.1 - 1.6e-06 28.2 1.6 0.38 10.6 0.1 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETN98497.1 - 0.0062 15.3 0.3 0.38 9.4 0.0 2.9 3 0 0 3 3 3 1 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETN98497.1 - 0.007 15.5 0.7 5.8 5.8 0.7 3.1 2 1 0 2 2 2 2 Coatomer WD associated region Proteasome_A_N PF10584.9 ETN98497.1 - 0.037 13.7 1.5 18 5.1 0.2 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETN98497.1 - 0.083 12.5 0.0 1.2 8.7 0.0 2.2 2 1 0 2 2 2 0 PQQ-like domain SGL PF08450.12 ETN98497.1 - 0.13 11.8 0.6 5.1 6.6 0.1 3.0 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region IKI3 PF04762.12 ETN98497.1 - 0.16 9.9 0.0 0.24 9.3 0.0 1.2 1 0 0 1 1 1 0 IKI3 family WD40 PF00400.32 ETN98498.1 - 1.8e-24 85.5 17.6 8.1e-07 29.6 0.4 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98498.1 - 4.8e-06 26.8 0.6 0.0077 16.5 0.1 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98498.1 - 0.024 13.3 2.3 3.9 6.0 0.0 3.3 1 1 3 4 4 4 0 Nucleoporin Nup120/160 PPR_2 PF13041.6 ETN98499.1 - 9.6e-11 41.7 2.0 0.00019 21.5 0.1 2.2 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETN98499.1 - 1.4e-08 34.4 0.2 0.0026 17.9 0.0 2.6 2 0 0 2 2 2 2 PPR repeat PPR_3 PF13812.6 ETN98499.1 - 1.2e-07 31.7 0.0 4.6e-06 26.6 0.0 2.5 2 1 0 2 2 2 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETN98499.1 - 9e-07 28.5 0.2 0.011 15.5 0.0 2.3 2 0 0 2 2 2 2 PPR repeat DUF2709 PF10915.8 ETN98499.1 - 0.0086 15.4 0.4 0.22 10.8 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF2709) DinB PF05163.12 ETN98500.1 - 0.093 12.6 0.6 0.11 12.4 0.6 1.1 1 0 0 1 1 1 0 DinB family DrsE PF02635.15 ETN98500.1 - 0.14 12.5 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 DsrE/DsrF-like family YabA PF06156.13 ETN98501.1 - 0.0012 19.4 7.5 0.0022 18.6 7.5 1.4 1 0 0 1 1 1 1 Initiation control protein YabA DUF5105 PF17118.5 ETN98501.1 - 0.01 15.6 1.5 0.015 15.1 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) zf-TRAF PF02176.18 ETN98501.1 - 0.012 16.3 3.6 0.012 16.3 1.9 2.0 2 0 0 2 2 2 0 TRAF-type zinc finger AAA_23 PF13476.6 ETN98501.1 - 0.58 10.6 9.3 0.75 10.3 9.2 1.3 1 1 0 1 1 1 0 AAA domain Herpes_BLRF2 PF05812.12 ETN98501.1 - 0.75 9.9 5.0 1.2 9.3 5.0 1.3 1 0 0 1 1 1 0 Herpesvirus BLRF2 protein DivIC PF04977.15 ETN98501.1 - 2 8.3 11.8 0.22 11.3 6.4 1.9 1 1 1 2 2 2 0 Septum formation initiator Geminin PF07412.12 ETN98502.1 - 0.092 12.5 14.5 0.071 12.8 10.6 1.9 1 1 1 2 2 2 0 Geminin DUF728 PF05304.12 ETN98502.1 - 0.75 9.6 4.7 0.79 9.6 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF728) SseC PF04888.12 ETN98502.1 - 2.9 7.4 10.6 2.9 7.4 10.6 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family WD40 PF00400.32 ETN98503.1 - 4.9e-17 62.0 5.1 1.4e-05 25.8 0.2 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN98503.1 - 0.00023 20.0 1.5 1.8 7.1 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF3973 PF13119.6 ETN98503.1 - 0.071 13.2 1.3 0.15 12.2 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3973) UpxZ PF06603.11 ETN98503.1 - 0.089 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 UpxZ family of transcription anti-terminator antagonists Leo1 PF04004.13 ETN98505.1 - 4.6e-23 81.9 1.1 7.6e-23 81.2 0.3 1.7 2 0 0 2 2 2 1 Leo1-like protein zf-UBP PF02148.19 ETN98506.1 - 1.1e-09 38.5 0.2 8.6e-09 35.6 0.0 2.2 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein FAD_syn PF06574.12 ETN98506.1 - 0.097 12.6 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 FAD synthetase Kelch_5 PF13854.6 ETN98507.1 - 0.00022 21.1 3.6 1.9 8.5 0.1 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETN98507.1 - 0.0015 18.7 1.1 1.1 9.6 0.1 4.0 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETN98507.1 - 0.013 15.5 3.0 3 8.0 0.0 3.6 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ETN98507.1 - 0.019 14.9 0.5 0.46 10.5 0.0 3.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98507.1 - 0.35 10.5 1.7 7.7 6.2 0.1 3.2 3 0 0 3 3 3 0 Kelch motif ZYG-11_interact PF05884.12 ETN98508.1 - 0.1 12.0 0.9 0.14 11.6 0.9 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 Exonuc_VII_L PF02601.15 ETN98508.1 - 2.3 7.7 6.6 2.8 7.4 6.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPR_1 PF00515.28 ETN98512.1 - 6.3e-16 57.4 12.1 1.8e-05 24.3 0.9 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98512.1 - 3.5e-14 51.7 0.8 0.00029 20.7 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETN98512.1 - 5.3e-12 45.9 2.0 0.017 15.4 0.3 3.1 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98512.1 - 5.4e-11 41.7 8.7 0.00047 20.1 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98512.1 - 1.4e-10 40.5 11.3 0.00065 19.7 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98512.1 - 2.7e-07 30.2 1.1 0.078 12.9 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat MIT PF04212.18 ETN98512.1 - 6.1e-05 23.0 7.9 0.21 11.6 0.1 3.2 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETN98512.1 - 8.2e-05 23.0 1.8 0.28 11.9 0.0 3.5 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98512.1 - 0.0011 19.5 0.0 13 6.9 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98512.1 - 0.01 16.4 0.0 31 5.3 0.0 3.1 2 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98512.1 - 0.24 11.1 14.0 3.9 7.3 1.1 4.1 3 1 1 4 4 4 0 TPR repeat Sel1 PF08238.12 ETN98512.1 - 0.27 12.0 2.6 6 7.7 0.2 3.0 3 0 0 3 3 3 0 Sel1 repeat TPR_19 PF14559.6 ETN98512.1 - 0.62 10.6 3.7 10 6.7 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETN98512.1 - 0.96 9.1 5.2 5 6.8 0.1 3.3 3 1 1 4 4 4 0 Helix-turn-helix bacterial domain NSF PF02071.20 ETN98512.1 - 4.8 8.4 7.4 1.1e+02 4.3 0.1 4.6 5 1 1 6 6 5 0 Aromatic-di-Alanine (AdAR) repeat PCI PF01399.27 ETN98513.1 - 0.0011 19.4 0.1 0.0021 18.5 0.1 1.6 1 1 0 1 1 1 1 PCI domain CUE PF02845.16 ETN98513.1 - 0.056 13.2 0.2 0.056 13.2 0.2 2.5 3 0 0 3 3 3 0 CUE domain Glyco_trans_4_5 PF16994.5 ETN98513.1 - 0.062 12.9 0.3 0.075 12.6 0.3 1.2 1 0 0 1 1 1 0 Glycosyl-transferase family 4 DUF2673 PF10880.8 ETN98513.1 - 0.45 10.7 4.9 0.23 11.6 1.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2673) HSP90 PF00183.18 ETN98516.1 - 1.6e-50 172.5 15.0 9.5e-32 110.6 2.0 2.0 1 1 1 2 2 2 2 Hsp90 protein HSP90 PF00183.18 ETN98517.1 - 1.8e-09 37.0 2.3 4.8e-09 35.6 1.8 1.8 1 1 0 1 1 1 1 Hsp90 protein Pkinase PF00069.25 ETN98519.1 - 1.5e-35 122.9 0.9 1.6e-35 122.7 0.9 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98519.1 - 3e-18 66.0 0.1 3.5e-18 65.8 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETN98519.1 - 0.00026 20.4 0.0 0.0005 19.5 0.0 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETN98519.1 - 0.03 13.3 0.1 0.034 13.1 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain DUF2490 PF10677.9 ETN98519.1 - 0.087 12.8 0.1 0.1 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2490) APH PF01636.23 ETN98519.1 - 0.1 12.5 0.1 0.17 11.8 0.1 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF4533 PF15047.6 ETN98520.1 - 0.002 17.7 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4533) DHC_N1 PF08385.12 ETN98521.1 - 0.0017 17.1 0.9 0.0024 16.6 0.9 1.3 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Pil1 PF13805.6 ETN98522.1 - 0.028 13.9 0.4 0.032 13.7 0.4 1.1 1 0 0 1 1 1 0 Eisosome component PIL1 DUF1213 PF06740.12 ETN98522.1 - 0.27 11.9 2.5 2.3 8.9 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) DNA_pol_A PF00476.20 ETN98523.1 - 3.4e-21 75.7 0.0 8.9e-20 71.1 0.0 2.2 1 1 0 1 1 1 1 DNA polymerase family A DNA_pol_A PF00476.20 ETN98524.1 - 8.4e-08 31.7 0.1 1.1e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 ETN98524.1 - 0.085 12.6 0.2 0.21 11.3 0.0 1.7 2 0 0 2 2 2 0 3'-5' exonuclease WD40 PF00400.32 ETN98526.1 - 1.6e-19 69.9 3.2 9.1e-06 26.3 0.0 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN98526.1 - 1.4e-05 23.9 1.5 0.57 8.8 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98526.1 - 0.00072 19.8 0.1 0.86 9.9 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETN98527.1 - 8.9e-31 105.5 3.8 4.3e-10 40.0 0.2 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98527.1 - 1e-05 25.7 0.1 0.041 14.2 0.0 2.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98527.1 - 8e-05 21.8 0.0 0.0097 14.9 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Str_synth PF03088.16 ETN98527.1 - 0.0044 17.1 0.1 0.017 15.2 0.0 2.0 2 0 0 2 2 2 1 Strictosidine synthase WD40_like PF17005.5 ETN98527.1 - 0.0048 16.3 0.3 0.0097 15.3 0.4 1.5 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETN98527.1 - 0.034 12.8 1.7 0.35 9.5 0.1 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 AAA PF00004.29 ETN98528.1 - 8.9e-10 39.1 0.1 0.00035 21.0 0.0 3.5 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETN98528.1 - 1.1e-07 31.6 1.7 0.011 15.3 0.0 4.1 4 0 0 4 4 4 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETN98528.1 - 2.7e-07 30.7 0.5 0.003 17.6 0.0 4.2 3 2 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETN98528.1 - 8.8e-07 29.3 0.0 0.11 12.8 0.0 4.0 3 0 0 3 3 3 2 AAA domain AAA_16 PF13191.6 ETN98528.1 - 4.5e-05 23.9 0.1 0.067 13.6 0.1 3.9 3 1 1 4 4 3 1 AAA ATPase domain IstB_IS21 PF01695.17 ETN98528.1 - 0.0003 20.6 0.0 0.41 10.4 0.0 3.6 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_8 PF12780.7 ETN98528.1 - 0.00032 20.1 0.6 0.0025 17.2 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 Rad17 PF03215.15 ETN98528.1 - 0.0011 19.0 6.5 4.8 7.1 0.1 3.9 3 1 0 3 3 3 2 Rad17 P-loop domain ABC_tran PF00005.27 ETN98528.1 - 0.0016 19.0 1.4 0.011 16.2 0.0 3.0 3 0 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 ETN98528.1 - 0.0019 18.2 0.0 0.0051 16.7 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase DUF815 PF05673.13 ETN98528.1 - 0.002 17.3 0.1 0.0077 15.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ETN98528.1 - 0.01 15.6 0.8 0.12 12.1 0.0 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 ETN98528.1 - 0.013 15.5 0.3 0.27 11.2 0.0 2.9 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 ETN98528.1 - 0.021 14.0 1.8 1.5 7.9 0.0 3.5 4 0 0 4 4 4 0 MCM P-loop domain ADSL_C PF10397.9 ETN98528.1 - 0.022 15.3 0.0 1.2 9.7 0.0 3.0 2 0 0 2 2 2 0 Adenylosuccinate lyase C-terminus NACHT PF05729.12 ETN98528.1 - 0.034 14.1 0.9 1.4 8.8 0.1 3.3 3 0 0 3 3 3 0 NACHT domain AAA_19 PF13245.6 ETN98528.1 - 0.035 14.4 0.0 22 5.4 0.0 3.2 3 0 0 3 3 2 0 AAA domain RNA_helicase PF00910.22 ETN98528.1 - 0.038 14.4 0.2 3.2 8.2 0.0 3.4 2 1 0 2 2 2 0 RNA helicase Mg_chelatase PF01078.21 ETN98528.1 - 0.07 12.5 0.1 19 4.6 0.1 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETN98528.1 - 0.11 12.2 0.0 1.1 9.0 0.0 2.5 3 0 0 3 3 2 0 Sigma-54 interaction domain Sigma54_activ_2 PF14532.6 ETN98528.1 - 0.27 11.4 2.3 1.8 8.6 0.0 3.4 4 1 1 5 5 3 0 Sigma-54 interaction domain AAA_23 PF13476.6 ETN98528.1 - 0.51 10.8 0.0 0.51 10.8 0.0 3.3 3 0 0 3 3 2 0 AAA domain Peptidase_S49_N PF08496.10 ETN98528.1 - 3.5 7.7 9.6 2.3 8.3 6.7 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal UCH PF00443.29 ETN98531.1 - 1.9e-07 30.9 0.1 4.2e-07 29.7 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETN98531.1 - 0.004 16.8 0.7 0.009 15.6 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_M99_m PF17130.4 ETN98532.1 - 0.46 10.4 3.7 0.33 10.9 1.3 2.1 2 1 0 2 2 2 0 beta-barrel domain of carboxypeptidase M99 HEAT PF02985.22 ETN98533.1 - 2.3e-11 42.9 0.0 2.2 8.7 0.0 8.8 9 0 0 9 9 9 2 HEAT repeat HEAT_EZ PF13513.6 ETN98533.1 - 9.7e-05 22.8 0.0 1.6 9.3 0.0 5.2 4 2 1 5 5 5 1 HEAT-like repeat Sec23_helical PF04815.15 ETN98533.1 - 0.00011 21.9 0.0 1.5 8.7 0.0 5.5 4 3 0 4 4 4 1 Sec23/Sec24 helical domain HEAT_2 PF13646.6 ETN98533.1 - 0.0015 18.9 0.0 0.41 11.1 0.0 4.2 3 1 0 4 4 4 1 HEAT repeats RTP1_C1 PF10363.9 ETN98533.1 - 0.002 18.3 19.5 0.26 11.5 1.0 6.2 2 2 2 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 MEDS PF14417.6 ETN98533.1 - 0.0034 17.2 0.0 0.15 11.9 0.0 3.3 2 1 0 3 3 3 1 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Cytochrom_C PF00034.21 ETN98533.1 - 0.0041 18.2 0.0 51 5.1 0.0 4.7 5 0 0 5 5 5 0 Cytochrome c NLRC4_HD2 PF17776.1 ETN98533.1 - 0.037 14.6 0.0 0.037 14.6 0.0 6.6 4 1 3 7 7 7 0 NLRC4 helical domain HD2 N_Asn_amidohyd PF14736.6 ETN98533.1 - 0.04 13.1 5.9 0.68 9.0 0.2 3.8 3 1 1 4 4 4 0 Protein N-terminal asparagine amidohydrolase Tfb5 PF06331.12 ETN98533.1 - 0.093 12.7 6.9 0.16 12.0 0.9 4.3 3 0 0 3 3 3 0 Transcription factor TFIIH complex subunit Tfb5 Viral_cys_rich PF08008.12 ETN98533.1 - 0.29 11.2 5.8 4.6 7.4 0.3 4.5 3 1 1 4 4 4 0 Viral cysteine rich Ndc80_HEC PF03801.13 ETN98533.1 - 5.6 6.6 16.7 0.18 11.4 0.5 4.4 4 1 1 5 5 5 0 HEC/Ndc80p family CD52 PF15116.6 ETN98534.1 - 0.14 12.2 0.3 0.33 11.0 0.3 1.7 1 0 0 1 1 1 0 CAMPATH-1 antigen Rota_NS26 PF01525.16 ETN98535.1 - 0.022 14.8 0.8 0.025 14.6 0.8 1.1 1 0 0 1 1 1 0 Rotavirus NS26 WD40 PF00400.32 ETN98536.1 - 8.1e-11 42.3 0.7 1.2e-09 38.6 0.1 2.8 3 0 0 3 3 3 1 WD domain, G-beta repeat Kelch_1 PF01344.25 ETN98536.1 - 1.3e-09 37.5 0.6 3.5e-05 23.3 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETN98536.1 - 2.5e-07 30.8 0.5 0.033 14.5 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETN98536.1 - 2.8e-07 30.4 0.0 0.0056 16.7 0.0 2.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN98536.1 - 2.3e-06 27.5 0.3 0.0067 16.4 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETN98536.1 - 9.3e-05 22.3 0.2 0.046 13.7 0.0 2.5 2 0 0 2 2 2 2 Kelch motif ANAPC4_WD40 PF12894.7 ETN98536.1 - 0.0011 19.2 0.0 0.003 17.8 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Kelch_3 PF13415.6 ETN98536.1 - 0.015 15.6 0.0 8.6 6.8 0.1 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Nup160 PF11715.8 ETN98536.1 - 0.065 11.9 0.0 0.095 11.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETN98537.1 - 1.3e-08 35.3 5.5 6.9e-08 33.0 1.3 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat zf-TRAF PF02176.18 ETN98537.1 - 5.9e-06 26.9 6.9 2.9e-05 24.7 6.9 2.3 1 0 0 1 1 1 1 TRAF-type zinc finger Spc7 PF08317.11 ETN98537.1 - 0.0011 17.9 22.1 0.0019 17.1 22.1 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein XRN_M PF17846.1 ETN98537.1 - 0.014 14.4 13.0 0.022 13.7 13.0 1.3 1 0 0 1 1 1 0 Xrn1 helical domain DUF641 PF04859.12 ETN98537.1 - 0.072 13.4 22.6 0.7 10.2 8.6 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) NPAT_C PF15712.5 ETN98537.1 - 0.25 10.0 14.9 0.26 9.9 14.9 1.1 1 0 0 1 1 1 0 NPAT C terminus DUF4407 PF14362.6 ETN98537.1 - 0.33 10.3 13.9 0.46 9.8 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 ETN98537.1 - 0.51 9.1 13.8 0.68 8.7 13.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter APG6_N PF17675.1 ETN98537.1 - 0.61 10.6 25.1 1.3 9.6 25.1 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region ArAE_2_N PF10337.9 ETN98537.1 - 0.63 9.0 6.6 0.77 8.7 6.6 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal FapA PF03961.13 ETN98537.1 - 3.1 6.3 23.2 5.2 5.6 23.2 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF1192 PF06698.11 ETN98537.1 - 3.1 7.9 7.7 5.8 7.0 0.2 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1192) HIP1_clath_bdg PF16515.5 ETN98537.1 - 5.5 7.7 26.7 2.7e+02 2.3 26.4 2.7 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 ETN98537.1 - 8.9 7.0 28.0 0.18 12.4 6.6 2.7 1 1 1 2 2 1 0 Initiation control protein YabA UBA PF00627.31 ETN98539.1 - 0.0093 15.9 0.2 0.016 15.1 0.2 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Choline_transpo PF04515.12 ETN98539.1 - 0.014 14.7 0.0 0.024 13.9 0.0 1.4 1 0 0 1 1 1 0 Plasma-membrane choline transporter ABC2_membrane_3 PF12698.7 ETN98539.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF3592 PF12158.8 ETN98539.1 - 0.02 15.0 0.0 0.03 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3592) LssY_C PF14067.6 ETN98539.1 - 0.083 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 LssY C-terminus APG6_N PF17675.1 ETN98540.1 - 0.0014 19.1 21.1 0.082 13.4 8.8 2.4 2 0 0 2 2 2 2 Apg6 coiled-coil region FlxA PF14282.6 ETN98540.1 - 0.0022 17.9 31.2 0.068 13.2 9.1 3.1 3 0 0 3 3 3 2 FlxA-like protein Spc7 PF08317.11 ETN98540.1 - 0.0052 15.7 23.7 0.0059 15.5 5.8 2.0 2 0 0 2 2 2 2 Spc7 kinetochore protein Uso1_p115_C PF04871.13 ETN98540.1 - 0.015 15.6 4.5 0.015 15.6 4.5 2.3 1 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Tropomyosin_1 PF12718.7 ETN98540.1 - 0.031 14.4 30.3 0.05 13.8 7.1 2.7 1 1 0 2 2 2 0 Tropomyosin like Snapin_Pallidin PF14712.6 ETN98540.1 - 0.033 14.6 6.7 0.033 14.6 6.7 2.9 2 2 0 2 2 2 0 Snapin/Pallidin PspA_IM30 PF04012.12 ETN98540.1 - 0.047 13.3 23.7 0.027 14.1 5.8 2.7 2 1 0 2 2 2 0 PspA/IM30 family Sas10 PF09368.10 ETN98540.1 - 0.073 13.6 0.6 0.073 13.6 0.6 2.3 1 1 0 2 2 2 0 Sas10 C-terminal domain Laminin_II PF06009.12 ETN98540.1 - 0.093 12.8 17.3 0.08 13.0 4.9 3.1 1 1 2 3 3 3 0 Laminin Domain II DUF2431 PF10354.9 ETN98540.1 - 0.14 12.4 7.0 0.053 13.8 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2431) DUF4407 PF14362.6 ETN98540.1 - 0.14 11.5 21.2 0.049 13.0 18.1 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) OmpH PF03938.14 ETN98540.1 - 0.15 12.4 29.1 0.21 11.9 6.5 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) HalX PF08663.10 ETN98540.1 - 0.17 12.2 0.2 0.17 12.2 0.2 4.2 2 2 2 4 4 4 0 HalX domain Golgin_A5 PF09787.9 ETN98540.1 - 0.18 11.2 24.8 0.21 11.0 7.2 2.3 2 1 0 2 2 2 0 Golgin subfamily A member 5 DUF1664 PF07889.12 ETN98540.1 - 0.23 11.5 17.0 0.049 13.7 4.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Phage_pRha PF09669.10 ETN98540.1 - 0.3 11.7 4.4 1.2 9.7 0.2 2.4 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Fib_alpha PF08702.10 ETN98540.1 - 0.39 10.9 21.6 0.027 14.7 8.1 2.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CLZ PF16526.5 ETN98540.1 - 0.48 10.8 23.0 1.6 9.1 0.2 4.3 1 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4200 PF13863.6 ETN98540.1 - 0.85 10.0 30.6 0.05 14.0 5.5 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Jnk-SapK_ap_N PF09744.9 ETN98540.1 - 0.86 9.8 28.6 1.5 9.0 0.1 3.0 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 HIP1_clath_bdg PF16515.5 ETN98540.1 - 0.94 10.1 28.8 0.058 14.0 6.7 2.9 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FUSC PF04632.12 ETN98540.1 - 1.3 7.5 4.8 10 4.5 3.5 1.8 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF724 PF05266.14 ETN98540.1 - 2 8.2 27.2 2.1 8.1 3.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF724) SpecificRecomb PF10136.9 ETN98540.1 - 2.2 6.5 7.3 2.3 6.5 6.6 1.2 1 1 0 1 1 1 0 Site-specific recombinase DUF948 PF06103.11 ETN98540.1 - 2.3 8.5 10.6 0.23 11.7 1.5 2.7 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) FlgN PF05130.12 ETN98540.1 - 3.4 8.2 21.0 4 8.0 17.8 2.4 1 1 1 2 2 2 0 FlgN protein FlaC_arch PF05377.11 ETN98540.1 - 3.9 7.9 17.3 0.2 12.1 1.7 4.1 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) Cluap1 PF10234.9 ETN98540.1 - 4 6.8 24.6 0.91 8.9 8.8 2.2 1 1 1 2 2 2 0 Clusterin-associated protein-1 TMF_DNA_bd PF12329.8 ETN98540.1 - 4 7.5 30.2 0.083 12.9 3.9 4.2 3 1 1 4 4 3 0 TATA element modulatory factor 1 DNA binding CREPT PF16566.5 ETN98540.1 - 5.9 7.1 17.4 2.7 8.2 3.6 2.6 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Exonuc_VII_L PF02601.15 ETN98540.1 - 6.7 6.2 19.6 40 3.6 19.6 1.9 1 1 0 1 1 1 0 Exonuclease VII, large subunit Osmo_CC PF08946.10 ETN98540.1 - 7.8 6.8 0.0 7.8 6.8 0.0 4.3 3 2 2 5 5 5 0 Osmosensory transporter coiled coil LPP PF04728.13 ETN98540.1 - 9 6.8 14.4 4.8 7.6 4.2 3.6 2 1 1 3 3 3 0 Lipoprotein leucine-zipper NPV_P10 PF05531.12 ETN98540.1 - 9.5 6.8 15.4 6.3 7.3 3.4 3.4 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF2828 PF11443.8 ETN98543.1 - 0.013 13.6 1.8 0.014 13.5 1.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) NARP1 PF12569.8 ETN98543.1 - 0.89 8.4 9.6 0.77 8.6 8.6 1.4 1 1 0 1 1 1 0 NMDA receptor-regulated protein 1 eIF_4EBP PF05456.11 ETN98543.1 - 1.2 9.1 6.2 0.59 10.1 3.9 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Presenilin PF01080.17 ETN98543.1 - 4.3 6.0 4.6 4.5 5.9 4.6 1.1 1 0 0 1 1 1 0 Presenilin Ca_hom_mod PF14798.6 ETN98544.1 - 0.0021 17.2 0.1 0.0033 16.6 0.1 1.5 1 1 0 1 1 1 1 Calcium homeostasis modulator FA_desaturase PF00487.24 ETN98545.1 - 4.3e-13 49.7 6.6 6.3e-13 49.2 6.6 1.1 1 0 0 1 1 1 1 Fatty acid desaturase DUF443 PF04276.12 ETN98546.1 - 0.023 14.5 0.0 0.051 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF443) Vma12 PF11712.8 ETN98546.1 - 0.43 10.6 6.3 0.86 9.7 6.3 1.6 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase AAA_11 PF13086.6 ETN98546.1 - 3.8 7.2 10.4 5.4 6.7 10.4 1.1 1 0 0 1 1 1 0 AAA domain MTP18 PF10558.9 ETN98546.1 - 6.7 6.6 8.6 22 4.9 0.2 2.3 1 1 1 2 2 2 0 Mitochondrial 18 KDa protein (MTP18) CDC73_C PF05179.14 ETN98547.1 - 4.1e-39 133.8 0.3 4.1e-39 133.8 0.3 2.1 2 0 0 2 2 2 1 RNA pol II accessory factor, Cdc73 family, C-terminal Secretin_N_2 PF07655.13 ETN98547.1 - 7.9 7.1 16.7 9.4 6.9 8.7 2.8 2 0 0 2 2 2 0 Secretin N-terminal domain TPR_12 PF13424.6 ETN98548.1 - 2.8e-28 98.0 0.2 4e-18 65.5 0.0 3.4 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98548.1 - 8.7e-21 72.8 11.5 2.5e-08 33.4 0.4 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98548.1 - 5.9e-20 69.7 6.6 2e-07 30.6 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98548.1 - 1.2e-18 65.7 0.1 9.7e-06 25.3 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98548.1 - 5.3e-18 64.3 0.0 8.7e-05 22.3 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98548.1 - 6.9e-18 63.3 10.2 6e-05 22.9 0.3 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98548.1 - 5e-06 26.8 1.8 0.036 14.7 0.1 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98548.1 - 2e-05 25.0 0.0 0.76 10.8 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN98548.1 - 0.00014 21.3 0.0 0.12 11.8 0.0 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 ETN98548.1 - 0.0003 21.4 0.0 0.33 11.7 0.0 2.8 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98548.1 - 0.00052 19.7 10.5 0.0028 17.3 0.7 4.2 4 1 0 4 4 4 1 TPR repeat SNAP PF14938.6 ETN98548.1 - 0.00074 19.0 0.5 0.076 12.4 0.2 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETN98548.1 - 0.0025 17.9 3.8 0.5 10.5 0.0 4.1 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETN98548.1 - 0.011 15.7 4.7 0.015 15.3 1.4 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETN98548.1 - 0.019 14.9 0.4 0.071 13.0 0.1 1.9 1 1 0 2 2 2 0 Caspase domain TPR_19 PF14559.6 ETN98548.1 - 0.023 15.2 0.0 2.8 8.5 0.0 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98548.1 - 0.037 14.4 3.5 7.7 7.1 0.0 4.1 5 0 0 5 5 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN98548.1 - 0.076 13.2 0.5 0.29 11.4 0.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 CIDE-N PF02017.15 ETN98548.1 - 0.12 12.4 0.4 0.72 9.9 0.2 2.2 2 0 0 2 2 2 0 CIDE-N domain Sel1 PF08238.12 ETN98548.1 - 0.27 12.0 1.4 8.9 7.2 0.0 3.3 3 1 0 3 3 3 0 Sel1 repeat HTH_Bact PF18768.1 ETN98548.1 - 4.5 6.9 6.0 8.8 6.0 0.0 3.4 2 1 0 2 2 2 0 Helix-turn-helix bacterial domain SYCP2_SLD PF18584.1 ETN98549.1 - 0.053 13.7 0.1 0.14 12.4 0.1 1.8 1 0 0 1 1 1 0 Synaptonemal complex 2 Spt16M-like domain AAA PF00004.29 ETN98551.1 - 3.7e-07 30.6 0.0 0.00026 21.4 0.0 3.4 3 0 0 3 3 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETN98551.1 - 5.8e-05 23.4 0.1 0.0037 17.5 0.0 3.6 4 0 0 4 4 3 1 AAA domain DUF815 PF05673.13 ETN98551.1 - 0.00083 18.6 0.0 0.0018 17.5 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETN98551.1 - 0.0031 18.0 0.1 0.022 15.3 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETN98551.1 - 0.0031 17.0 0.2 0.023 14.2 0.0 2.6 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 ETN98551.1 - 0.0043 17.1 0.2 0.3 11.1 0.0 3.7 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ETN98551.1 - 0.0049 16.9 0.0 0.059 13.4 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ETN98551.1 - 0.0055 16.6 0.0 0.02 14.8 0.0 2.0 1 0 0 1 1 1 1 RsgA GTPase NACHT PF05729.12 ETN98551.1 - 0.01 15.8 0.7 2.8 7.8 0.1 3.8 3 0 0 3 3 3 0 NACHT domain IstB_IS21 PF01695.17 ETN98551.1 - 0.023 14.4 0.1 1.3 8.8 0.0 2.9 3 0 0 3 3 3 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ETN98551.1 - 0.032 14.6 0.0 0.96 9.9 0.0 3.4 2 0 0 2 2 2 0 RNA helicase MCM PF00493.23 ETN98551.1 - 0.034 13.3 0.2 0.22 10.6 0.0 2.4 3 0 0 3 3 3 0 MCM P-loop domain AAA_16 PF13191.6 ETN98551.1 - 0.092 13.1 0.0 0.36 11.2 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 ETN98551.1 - 0.1 12.4 0.1 0.24 11.2 0.1 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 ETN98551.1 - 0.11 12.5 0.0 0.45 10.5 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PDE4_UCR PF18100.1 ETN98551.1 - 5.1 7.8 13.2 0.11 13.2 0.6 3.9 3 1 0 4 4 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) AAA_24 PF13479.6 ETN98551.1 - 6 6.5 8.1 1.2 8.8 0.0 3.7 4 0 0 4 4 4 0 AAA domain WD40 PF00400.32 ETN98553.1 - 1.9e-31 107.6 20.0 2.5e-06 28.1 0.3 6.0 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETN98553.1 - 3.8e-10 39.0 7.7 0.021 13.5 0.1 4.7 1 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98553.1 - 1.9e-09 37.7 0.5 0.098 13.0 0.0 4.8 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETN98553.1 - 0.0011 19.0 2.5 1.5 8.9 0.3 3.5 3 2 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF851 PF05867.11 ETN98553.1 - 0.014 14.8 0.0 3 7.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF851) DUF1140 PF06600.11 ETN98553.1 - 0.08 13.4 3.4 0.048 14.1 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1140) DUF1348 PF07080.11 ETN98553.1 - 0.15 12.0 1.7 0.34 10.8 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1348) Read-through PF16814.5 ETN98553.1 - 0.2 11.4 3.4 3.1 7.5 0.1 3.0 1 1 2 3 3 3 0 Read-through domain SpecificRecomb PF10136.9 ETN98554.1 - 0.09 11.1 0.3 0.11 10.7 0.3 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF3323 PF11796.8 ETN98555.1 - 0.16 11.8 0.1 0.23 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) GAS PF13851.6 ETN98556.1 - 1.3 8.3 11.1 0.28 10.5 3.4 2.5 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding IFT81_CH PF18383.1 ETN98557.1 - 0.015 15.5 3.5 0.25 11.6 0.0 3.1 2 1 1 3 3 3 0 Intraflagellar transport 81 calponin homology domain PUB PF09409.10 ETN98557.1 - 0.025 14.5 1.9 0.22 11.5 1.9 2.5 1 1 0 1 1 1 0 PUB domain EF_TS PF00889.19 ETN98557.1 - 0.044 13.4 0.1 0.054 13.1 0.1 1.2 1 0 0 1 1 1 0 Elongation factor TS DUF2951 PF11166.8 ETN98557.1 - 0.96 9.7 6.2 1.7 9.0 1.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) WD40 PF00400.32 ETN98559.1 - 1.1e-08 35.6 6.9 0.00028 21.6 0.8 3.3 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98559.1 - 0.014 15.7 0.1 1.7 9.0 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98559.1 - 0.02 13.5 0.1 0.19 10.3 0.1 1.9 1 1 0 1 1 1 0 Nucleoporin Nup120/160 RTC_insert PF05189.13 ETN98560.1 - 0.063 13.8 0.1 0.097 13.2 0.1 1.4 1 0 0 1 1 1 0 RNA 3'-terminal phosphate cyclase (RTC), insert domain CALM_bind PF16025.5 ETN98560.1 - 1 9.9 3.5 0.45 11.0 0.4 2.0 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding Menin PF05053.13 ETN98560.1 - 4.1 5.7 10.0 5.1 5.3 10.0 1.1 1 0 0 1 1 1 0 Menin FAM176 PF14851.6 ETN98561.1 - 7.2e-07 29.0 0.1 0.0006 19.5 0.0 2.2 2 0 0 2 2 2 2 FAM176 family LRR19-TM PF15176.6 ETN98561.1 - 0.0085 16.1 0.3 3.2 7.8 0.1 2.5 2 0 0 2 2 2 2 Leucine-rich repeat family 19 TM domain TMEM237 PF15383.6 ETN98561.1 - 0.049 12.7 1.9 0.077 12.1 0.1 2.2 2 0 0 2 2 2 0 Transmembrane protein 237 DUF4611 PF15387.6 ETN98561.1 - 0.069 13.4 1.1 0.069 13.4 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Saf_2TM PF18303.1 ETN98561.1 - 0.082 12.5 6.0 4 7.0 0.0 3.1 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain P22_AR_C PF10548.9 ETN98562.1 - 0.13 12.4 0.8 0.91 9.7 0.1 2.2 2 1 0 2 2 2 0 P22AR C-terminal domain RE_Alw26IDE PF09665.10 ETN98562.1 - 0.2 10.8 1.5 0.23 10.6 1.5 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) Lge1 PF11488.8 ETN98562.1 - 0.47 10.7 3.1 1.9 8.7 3.1 2.0 1 1 0 1 1 1 0 Transcriptional regulatory protein LGE1 PPR_2 PF13041.6 ETN98563.1 - 0.0027 17.9 1.3 0.0063 16.7 0.2 2.0 2 0 0 2 2 2 1 PPR repeat family Pentapeptide PF00805.22 ETN98564.1 - 1.5e-12 46.9 4.8 6.8e-06 25.6 0.9 2.3 1 1 2 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETN98564.1 - 1.4e-05 25.1 0.6 3.3e-05 24.0 0.1 1.8 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETN98564.1 - 0.0022 18.1 0.1 0.0043 17.2 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) WD40 PF00400.32 ETN98564.1 - 0.016 16.1 0.0 0.036 14.9 0.0 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat SHMT PF00464.19 ETN98564.1 - 0.083 11.5 0.1 0.12 10.9 0.1 1.2 1 0 0 1 1 1 0 Serine hydroxymethyltransferase CorA PF01544.18 ETN98567.1 - 1.2e-12 47.8 0.3 1.3e-12 47.6 0.3 1.0 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Glyco_hydro_85 PF03644.13 ETN98570.1 - 0.022 14.2 0.2 0.022 14.2 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 85 GreA_GreB_N PF03449.15 ETN98570.1 - 0.065 13.4 0.2 0.12 12.6 0.2 1.5 1 1 0 1 1 1 0 Transcription elongation factor, N-terminal Herpes_ORF11 PF04797.13 ETN98570.1 - 0.077 11.8 0.1 0.082 11.7 0.1 1.0 1 0 0 1 1 1 0 Herpesvirus dUTPase protein HMMR_N PF15905.5 ETN98571.1 - 0.0099 15.4 5.4 0.012 15.1 5.4 1.0 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal BST2 PF16716.5 ETN98571.1 - 1.1 9.9 5.6 2 9.1 5.6 1.4 1 1 0 1 1 1 0 Bone marrow stromal antigen 2 Ldl_recept_a PF00057.18 ETN98572.1 - 0.018 15.2 2.6 0.04 14.1 2.6 1.6 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A MULE PF10551.9 ETN98573.1 - 0.011 16.2 0.3 0.014 15.8 0.3 1.3 1 0 0 1 1 1 0 MULE transposase domain DUF2547 PF10818.8 ETN98573.1 - 0.16 12.9 3.0 0.17 12.8 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) E1-E2_ATPase PF00122.20 ETN98573.1 - 0.44 10.1 3.1 0.69 9.4 3.1 1.3 1 0 0 1 1 1 0 E1-E2 ATPase CDC45 PF02724.14 ETN98577.1 - 4.9 5.3 19.1 5.6 5.1 19.1 1.1 1 0 0 1 1 1 0 CDC45-like protein TPR_12 PF13424.6 ETN98578.1 - 2.5e-51 171.9 5.5 1.3e-20 73.5 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98578.1 - 3.4e-37 125.3 6.2 1.1e-11 44.2 0.0 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98578.1 - 7e-29 98.4 19.0 8.4e-10 38.1 0.7 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98578.1 - 8.3e-28 94.4 0.4 4.4e-08 32.6 0.0 3.5 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98578.1 - 3.2e-27 92.4 17.2 8.1e-09 35.0 1.1 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98578.1 - 4.2e-24 82.7 9.9 2.4e-07 30.3 0.3 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_3 PF07720.12 ETN98578.1 - 2.9e-11 43.1 5.7 0.0029 17.5 0.2 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98578.1 - 8.6e-11 41.4 7.4 0.065 13.6 0.0 4.9 4 3 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98578.1 - 1.8e-10 41.3 0.0 0.00037 21.1 0.0 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98578.1 - 7.6e-10 38.8 0.1 0.28 11.9 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98578.1 - 1.2e-09 37.7 23.3 0.0014 18.2 1.1 5.5 4 2 2 6 6 6 4 TPR repeat TPR_14 PF13428.6 ETN98578.1 - 9.6e-09 35.3 0.0 0.18 12.7 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN98578.1 - 8.9e-08 32.3 2.7 0.0021 18.2 0.8 3.0 2 1 1 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETN98578.1 - 2.3e-07 30.7 2.7 0.13 12.1 0.1 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF5113) MIT PF04212.18 ETN98578.1 - 1.8e-06 27.9 8.4 0.0061 16.6 0.2 3.1 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF4810 PF16068.5 ETN98578.1 - 2.3e-06 28.0 1.6 1.6 9.3 0.0 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4810) ATP-synt_E_2 PF08112.11 ETN98578.1 - 1e-05 25.7 3.8 0.61 10.4 0.1 3.2 3 0 0 3 3 3 2 ATP synthase epsilon subunit PPR PF01535.20 ETN98578.1 - 4.2e-05 23.5 3.0 0.072 13.4 0.2 3.3 3 0 0 3 3 3 1 PPR repeat RPN7 PF10602.9 ETN98578.1 - 0.00014 21.6 2.4 0.079 12.7 0.2 2.6 1 1 1 2 2 2 2 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ETN98578.1 - 0.00015 21.2 0.0 0.00021 20.8 0.0 1.2 1 0 0 1 1 1 1 MalT-like TPR region Mob_Pre PF01076.19 ETN98578.1 - 0.00027 20.8 0.2 0.00072 19.4 0.2 1.6 1 1 1 2 2 2 1 Plasmid recombination enzyme SHNi-TPR PF10516.9 ETN98578.1 - 0.00036 19.9 0.0 6.3 6.3 0.0 3.3 3 0 0 3 3 3 0 SHNi-TPR SNAP PF14938.6 ETN98578.1 - 0.0019 17.7 3.0 0.018 14.4 3.1 2.1 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 ETN98578.1 - 0.002 18.7 10.8 1.4 9.7 0.3 4.6 3 3 0 3 3 3 1 Sel1 repeat DUF627 PF04781.12 ETN98578.1 - 0.0031 17.5 0.0 6.9 6.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF627) EST1_DNA_bind PF10373.9 ETN98578.1 - 0.0043 16.6 1.1 4.1 6.8 0.1 3.0 3 0 0 3 3 3 1 Est1 DNA/RNA binding domain TPR_19 PF14559.6 ETN98578.1 - 0.0051 17.3 0.1 0.24 11.9 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat mRNA_cap_C PF03919.15 ETN98578.1 - 0.013 16.1 0.0 12 6.5 0.0 3.1 2 1 0 3 3 2 0 mRNA capping enzyme, C-terminal domain Vps39_1 PF10366.9 ETN98578.1 - 0.049 13.9 2.4 1.4 9.2 0.1 2.9 1 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 HTH_Bact PF18768.1 ETN98578.1 - 0.093 12.3 6.7 9.1 6.0 0.1 3.6 3 1 0 3 3 3 0 Helix-turn-helix bacterial domain Raftlin PF15250.6 ETN98578.1 - 0.17 10.6 0.1 0.96 8.1 0.0 1.9 1 1 1 2 2 2 0 Raftlin PPR_2 PF13041.6 ETN98578.1 - 0.2 11.8 3.9 2 8.7 0.2 3.0 3 0 0 3 3 3 0 PPR repeat family TCTP PF00838.17 ETN98578.1 - 0.43 10.9 3.2 7.2 6.9 0.1 2.7 1 1 2 3 3 3 0 Translationally controlled tumour protein Fis1_TPR_C PF14853.6 ETN98578.1 - 0.64 10.1 7.3 5.8 7.1 0.2 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Rota_NSP3 PF01665.16 ETN98578.1 - 0.65 9.1 2.3 21 4.1 0.1 2.7 1 1 2 3 3 3 0 Rotavirus non-structural protein NSP3 AAA_5 PF07728.14 ETN98579.1 - 1.8e-07 31.2 0.0 3.9e-07 30.1 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETN98579.1 - 3.7e-06 27.4 0.0 8.5e-06 26.2 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ETN98579.1 - 7.8e-05 23.2 0.0 0.0002 21.9 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETN98579.1 - 0.00039 20.0 0.0 0.0013 18.3 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_8 PF12780.7 ETN98579.1 - 0.00046 19.6 0.1 0.0017 17.7 0.0 1.9 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_22 PF13401.6 ETN98579.1 - 0.0007 19.9 0.0 0.0034 17.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETN98579.1 - 0.00075 19.9 0.0 0.0015 19.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ETN98579.1 - 0.0013 18.8 0.2 0.0047 17.0 0.0 2.0 3 0 0 3 3 2 1 AAA domain RsgA_GTPase PF03193.16 ETN98579.1 - 0.0022 17.9 0.0 0.0037 17.2 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase TsaE PF02367.17 ETN98579.1 - 0.0068 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 ETN98579.1 - 0.0087 15.8 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 ETN98579.1 - 0.0092 15.2 0.0 0.015 14.5 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) MCM PF00493.23 ETN98579.1 - 0.012 14.7 0.0 0.038 13.1 0.0 1.8 2 0 0 2 2 2 0 MCM P-loop domain NACHT PF05729.12 ETN98579.1 - 0.032 14.1 0.3 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 ETN98579.1 - 0.033 13.9 0.1 0.09 12.5 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 ETN98579.1 - 0.034 14.0 0.0 0.061 13.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ETN98579.1 - 0.048 13.4 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Rad17 PF03215.15 ETN98579.1 - 0.049 13.6 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 ETN98579.1 - 0.05 14.1 0.5 0.16 12.4 0.0 2.0 2 1 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 ETN98579.1 - 0.067 13.3 0.0 0.15 12.1 0.0 1.6 2 0 0 2 2 1 0 Sigma-54 interaction domain ATP-synt_ab PF00006.25 ETN98579.1 - 0.075 12.7 0.0 0.19 11.4 0.0 1.5 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain Zeta_toxin PF06414.12 ETN98579.1 - 0.084 12.1 0.0 0.15 11.3 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin MMR_HSR1 PF01926.23 ETN98579.1 - 0.11 12.6 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 ETN98579.1 - 0.12 12.8 0.0 0.39 11.1 0.0 2.0 1 0 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.18 ETN98579.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 ETN98579.1 - 0.15 12.4 0.1 0.45 10.8 0.1 1.6 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 ETN98580.1 - 1.3e-10 41.7 9.2 4.3e-05 24.2 0.4 4.1 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98580.1 - 0.00055 20.2 0.1 6.8 7.1 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98580.1 - 0.00069 18.4 1.2 0.49 9.0 0.0 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETN98580.1 - 0.028 13.2 0.8 0.042 12.6 0.8 1.3 1 1 0 1 1 1 0 Nup133 N terminal like Apis_Csd PF11671.8 ETN98581.1 - 0.49 10.4 8.4 0.65 10.0 8.4 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein KleE PF17394.2 ETN98583.1 - 0.064 13.5 0.0 0.078 13.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein Fascin PF06268.13 ETN98584.1 - 0.0044 17.2 0.1 0.0067 16.6 0.1 1.2 1 0 0 1 1 1 1 Fascin domain OEP PF02321.18 ETN98584.1 - 0.089 12.6 3.0 0.13 12.1 3.0 1.2 1 0 0 1 1 1 0 Outer membrane efflux protein CBM26 PF16738.5 ETN98585.1 - 0.66 10.3 4.1 1.4 9.2 0.1 2.3 2 0 0 2 2 2 0 Starch-binding module 26 WD40 PF00400.32 ETN98587.1 - 1.4e-35 120.6 10.0 1.6e-11 44.6 0.1 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98587.1 - 8e-15 54.9 0.9 9.2e-05 22.7 0.0 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98587.1 - 2.6e-13 49.7 0.0 0.0021 17.1 0.0 3.6 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETN98587.1 - 4.4e-07 30.0 0.1 7.4e-07 29.2 0.1 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETN98587.1 - 2.3e-06 26.6 1.3 0.0051 15.5 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETN98587.1 - 9e-05 21.2 0.1 0.00028 19.5 0.1 1.7 1 1 0 1 1 1 1 Cytochrome D1 heme domain PD40 PF07676.12 ETN98587.1 - 0.0006 19.7 3.4 1.1 9.3 0.1 3.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETN98587.1 - 0.0017 17.7 0.0 0.057 12.7 0.0 2.2 1 1 1 2 2 2 1 WD40-like domain Nucleoporin_N PF08801.11 ETN98587.1 - 0.0041 15.9 2.1 0.3 9.8 0.1 2.7 1 1 2 3 3 3 2 Nup133 N terminal like Nbas_N PF15492.6 ETN98587.1 - 0.015 14.6 0.4 0.74 9.1 0.0 2.5 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETN98587.1 - 0.018 15.1 1.2 5.7 7.1 0.3 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5570) SGL PF08450.12 ETN98587.1 - 0.027 14.1 0.3 0.046 13.3 0.2 1.5 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region Utp8 PF10395.9 ETN98587.1 - 0.074 11.5 0.0 0.18 10.3 0.0 1.5 1 1 1 2 2 2 0 Utp8 family WD40 PF00400.32 ETN98589.1 - 4.8e-13 49.4 7.6 5.5e-06 27.0 1.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98589.1 - 6e-07 28.5 1.8 0.0013 17.5 0.3 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98589.1 - 0.00055 20.2 0.1 0.015 15.6 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain BLF1 PF17752.1 ETN98589.1 - 0.0044 16.4 0.2 0.0054 16.1 0.2 1.3 1 0 0 1 1 1 1 Burkholderia lethal factor 1 BRCT_2 PF16589.5 ETN98591.1 - 0.083 13.3 0.6 0.083 13.3 0.6 2.2 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETN98591.1 - 0.1 13.0 2.5 0.1 13.0 0.2 2.2 2 1 1 3 3 3 0 BRCA1 C Terminus (BRCT) domain ALMT PF11744.8 ETN98591.1 - 0.2 10.5 9.7 0.2 10.4 8.9 1.2 1 1 0 1 1 1 0 Aluminium activated malate transporter CDC4_D PF16856.5 ETN98592.1 - 0.12 12.2 3.2 0.48 10.3 0.3 2.2 2 0 0 2 2 2 0 Cell division control protein 4 dimerisation domain Solute_trans_a PF03619.16 ETN98593.1 - 6.5e-36 124.2 6.2 7.7e-36 124.0 6.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PIRT PF15099.6 ETN98593.1 - 0.054 13.1 0.2 0.1 12.2 0.2 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family UCMA PF17085.5 ETN98594.1 - 0.061 13.3 1.2 0.08 12.9 0.8 1.4 1 1 0 1 1 1 0 Unique cartilage matrix associated protein ANAPC8 PF04049.13 ETN98595.1 - 0.11 12.5 0.6 0.14 12.2 0.6 1.1 1 0 0 1 1 1 0 Anaphase promoting complex subunit 8 / Cdc23 CRAL_TRIO PF00650.20 ETN98596.1 - 7.9e-12 45.2 0.2 9.7e-12 44.9 0.2 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain DASH_Dad1 PF08649.10 ETN98597.1 - 0.0083 16.3 5.4 0.31 11.2 0.1 4.1 3 0 0 3 3 3 1 DASH complex subunit Dad1 TPR_MLP1_2 PF07926.12 ETN98597.1 - 0.013 15.6 40.7 0.59 10.2 23.2 3.3 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein GARP PF16731.5 ETN98597.1 - 0.46 10.2 14.2 0.86 9.3 8.1 2.8 2 1 1 3 3 3 0 Glutamic acid/alanine-rich protein of Trypanosoma DUF1192 PF06698.11 ETN98597.1 - 0.48 10.5 7.8 0.85 9.7 0.4 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF1192) Spc7 PF08317.11 ETN98597.1 - 2.1 7.2 46.0 0.039 12.8 15.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Muted PF14942.6 ETN98597.1 - 4.7 7.5 44.6 0.23 11.8 16.4 3.1 1 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein MitMem_reg PF13012.6 ETN98597.1 - 8.9 6.8 20.3 2.6 8.5 5.9 3.2 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function Acyl-CoA_ox_N PF14749.6 ETN98598.1 - 0.061 13.9 0.8 0.061 13.9 0.8 1.6 1 1 1 2 2 2 0 Acyl-coenzyme A oxidase N-terminal YMF19 PF02326.15 ETN98598.1 - 0.2 12.5 4.2 0.61 10.9 3.9 2.1 1 1 0 1 1 1 0 Plant ATP synthase F0 Presenilin PF01080.17 ETN98598.1 - 2.1 7.0 4.8 2.5 6.8 4.8 1.1 1 0 0 1 1 1 0 Presenilin zf-RRPl_C4 PF17026.5 ETN98599.1 - 0.018 15.1 2.1 2.8 8.1 0.8 2.6 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type NdhM PF10664.9 ETN98599.1 - 0.092 13.0 0.1 0.24 11.7 0.1 1.6 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M Kelch_1 PF01344.25 ETN98600.1 - 2.8e-07 30.0 2.6 0.00013 21.5 0.1 2.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETN98600.1 - 4e-05 23.5 3.8 0.00041 20.3 0.4 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN98600.1 - 4e-05 23.7 6.5 0.0047 17.2 0.5 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETN98600.1 - 0.00017 21.5 6.8 0.0067 16.4 0.8 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETN98600.1 - 0.03 14.3 0.7 4.4 7.4 0.1 3.1 3 0 0 3 3 3 0 Kelch motif ATG16 PF08614.11 ETN98601.1 - 0.00061 20.1 24.3 0.00061 20.1 24.3 3.0 1 1 2 3 3 3 2 Autophagy protein 16 (ATG16) DUF2353 PF09789.9 ETN98601.1 - 0.0013 18.1 36.3 0.0013 18.1 36.3 2.5 1 1 2 3 3 3 1 Uncharacterized coiled-coil protein (DUF2353) KASH_CCD PF14662.6 ETN98601.1 - 0.0014 18.5 32.6 0.0014 18.5 32.6 3.3 1 1 2 3 3 3 1 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.7 ETN98601.1 - 0.0061 16.7 67.6 0.039 14.1 26.9 3.0 1 1 2 3 3 3 2 Tropomyosin like bZIP_1 PF00170.21 ETN98601.1 - 0.017 15.2 11.5 0.033 14.3 2.6 7.0 1 1 3 6 6 5 0 bZIP transcription factor BLOC1_2 PF10046.9 ETN98601.1 - 0.028 14.7 11.1 0.028 14.7 11.1 5.3 1 1 5 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 ETN98601.1 - 0.056 13.5 63.5 0.039 14.0 19.4 3.7 1 1 3 4 4 4 0 TPR/MLP1/MLP2-like protein GAS PF13851.6 ETN98601.1 - 0.079 12.3 72.3 0.9 8.8 9.5 3.2 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF3584 PF12128.8 ETN98601.1 - 0.1 10.1 54.3 0.042 11.4 31.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) CENP-F_leu_zip PF10473.9 ETN98601.1 - 0.38 10.8 65.2 0.58 10.2 28.8 3.5 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FUSC PF04632.12 ETN98601.1 - 0.56 8.7 0.7 0.96 7.9 0.1 1.5 1 1 1 2 2 2 0 Fusaric acid resistance protein family Atg14 PF10186.9 ETN98601.1 - 1.4 8.0 62.5 0.16 11.0 22.4 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 kleA_kleC PF17383.2 ETN98601.1 - 1.4 9.3 12.9 1.1 9.6 2.0 3.3 2 1 1 3 3 3 0 Uncharacterized KorC regulated protein A Fez1 PF06818.15 ETN98601.1 - 1.4 9.3 56.0 9.5 6.6 27.2 2.3 1 1 1 2 2 2 0 Fez1 ERM PF00769.19 ETN98601.1 - 1.6 8.5 57.6 0.11 12.4 26.0 2.9 1 1 2 3 3 3 0 Ezrin/radixin/moesin family DUF5082 PF16888.5 ETN98601.1 - 2 8.7 52.6 0.91 9.8 21.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) JIP_LZII PF16471.5 ETN98601.1 - 2.2 8.5 48.3 1.1 9.5 1.9 6.0 2 1 3 5 5 5 0 JNK-interacting protein leucine zipper II Mod_r PF07200.13 ETN98601.1 - 2.5 8.2 60.2 18 5.4 22.8 4.0 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein CALCOCO1 PF07888.11 ETN98601.1 - 4.2 6.1 54.4 9.5 5.0 54.5 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Jnk-SapK_ap_N PF09744.9 ETN98601.1 - 6.1 7.1 64.6 60 3.8 31.0 3.3 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 ETN98601.1 - 6.5 5.5 64.6 2.5 6.9 25.2 3.1 1 1 2 3 3 3 0 Spc7 kinetochore protein HemX PF04375.14 ETN98601.1 - 7.3 5.8 50.4 4.8 6.4 11.4 3.4 1 1 3 4 4 4 0 HemX, putative uroporphyrinogen-III C-methyltransferase Filament PF00038.21 ETN98601.1 - 7.7 6.0 55.7 0.81 9.2 15.9 3.1 1 1 1 3 3 3 0 Intermediate filament protein CEP63 PF17045.5 ETN98601.1 - 8.5 6.2 56.1 31 4.4 56.1 1.9 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa Spectrin PF00435.21 ETN98601.1 - 9.4 6.8 48.5 0.82 10.2 10.1 4.1 1 1 2 4 4 4 0 Spectrin repeat SecA_DEAD PF07517.14 ETN98602.1 - 3.1e-06 26.7 0.0 5.9e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain NACHT PF05729.12 ETN98605.1 - 1.6e-05 24.9 0.0 3.1e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Kinesin PF00225.23 ETN98606.1 - 2.3e-07 30.1 5.2 6.5e-07 28.6 5.2 1.8 1 1 0 1 1 1 1 Kinesin motor domain CheW PF01584.19 ETN98606.1 - 0.041 13.5 0.0 0.072 12.7 0.0 1.4 1 0 0 1 1 1 0 CheW-like domain DUF4716 PF15837.5 ETN98606.1 - 0.099 12.7 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4716) DnaJ PF00226.31 ETN98607.1 - 1.1e-16 60.7 1.0 4.6e-12 45.9 0.0 2.9 3 0 0 3 3 3 2 DnaJ domain Adeno_E3_15_3 PF03307.14 ETN98607.1 - 0.05 13.6 2.9 0.072 13.0 0.1 2.5 3 0 0 3 3 3 0 Adenovirus 15.3kD protein in E3 region DUF5118 PF17162.4 ETN98607.1 - 0.091 12.6 0.3 0.32 10.9 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5118) Herpes_U44 PF04533.13 ETN98611.1 - 0.096 12.3 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Herpes virus U44 protein YL1 PF05764.13 ETN98612.1 - 0.01 16.0 14.9 0.011 15.8 14.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein AAA_assoc_2 PF16193.5 ETN98612.1 - 0.22 11.9 2.2 0.49 10.8 2.2 1.7 1 1 0 1 1 1 0 AAA C-terminal domain RRN3 PF05327.11 ETN98612.1 - 0.25 9.8 5.3 0.24 9.9 5.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LAX PF15681.5 ETN98612.1 - 0.37 9.6 3.8 0.48 9.2 3.8 1.2 1 0 0 1 1 1 0 Lymphocyte activation family X Renin_r PF07850.14 ETN98612.1 - 0.47 11.1 3.4 6.5 7.4 0.1 2.5 2 0 0 2 2 2 0 Renin receptor-like protein B277 PF17623.2 ETN98612.1 - 1.5 7.8 6.3 1.9 7.5 6.3 1.1 1 0 0 1 1 1 0 Domain of unknown function CDC45 PF02724.14 ETN98612.1 - 7.8 4.7 15.2 8.7 4.5 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein TIP120 PF08623.10 ETN98613.1 - 0.00012 21.9 1.4 0.011 15.5 0.1 2.5 2 1 0 2 2 2 2 TATA-binding protein interacting (TIP20) Spore_III_AB PF09548.10 ETN98613.1 - 0.021 15.0 0.5 0.066 13.3 0.2 1.9 1 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Ras PF00071.22 ETN98615.1 - 8.6e-09 35.2 0.2 3.2e-08 33.3 0.0 1.9 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETN98615.1 - 1e-08 35.4 0.0 3.3e-08 33.8 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase YqaH PF17448.2 ETN98615.1 - 0.00074 19.8 0.1 0.0012 19.1 0.1 1.4 1 0 0 1 1 1 1 Uncharacterized YqaH-like Arf PF00025.21 ETN98615.1 - 0.0036 16.8 3.2 0.037 13.5 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family TsaE PF02367.17 ETN98615.1 - 0.024 14.7 0.6 0.091 12.8 0.0 2.0 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE WD40 PF00400.32 ETN98617.1 - 1.4e-14 54.2 9.0 9.5e-05 23.1 0.0 4.1 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98617.1 - 0.005 17.1 0.1 0.96 9.8 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain LOR PF04525.12 ETN98617.1 - 0.083 12.5 2.0 1.4 8.5 0.1 2.3 2 1 0 2 2 2 0 LURP-one-related Pro-NT_NN PF07421.11 ETN98619.1 - 0.8 10.0 9.6 0.81 9.9 1.9 2.5 2 1 0 2 2 2 0 Neurotensin/neuromedin N precursor Tnp_22_trimer PF17489.2 ETN98620.1 - 0.04 13.9 6.2 0.15 12.0 0.4 2.3 2 0 0 2 2 2 0 L1 transposable element trimerization domain Terminase_2 PF03592.16 ETN98620.1 - 0.083 13.4 2.3 0.093 13.2 2.3 1.1 1 0 0 1 1 1 0 Terminase small subunit Exo84_C PF16528.5 ETN98621.1 - 4.7e-06 26.6 0.1 8.4e-06 25.7 0.1 1.3 1 0 0 1 1 1 1 Exocyst component 84 C-terminal RNase_H2_suC PF08615.11 ETN98621.1 - 7.9 6.7 6.7 1.2 9.3 1.8 2.0 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DNA_pol_E_B PF04042.16 ETN98622.1 - 0.06 12.7 0.1 0.081 12.3 0.1 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B DUF3130 PF11328.8 ETN98623.1 - 0.035 14.3 0.1 0.059 13.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3130 Sec16 PF12932.7 ETN98624.1 - 0.0025 18.4 0.1 0.0055 17.3 0.1 1.6 1 0 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Fungal_KA1 PF16797.5 ETN98624.1 - 0.1 12.3 0.2 0.28 10.9 0.2 1.8 1 1 0 1 1 1 0 Fungal kinase associated-1 domain Sec16 PF12932.7 ETN98625.1 - 0.0054 17.3 0.4 0.0094 16.5 0.3 1.4 1 1 0 1 1 1 1 Vesicle coat trafficking protein Sec16 mid-region Fungal_KA1 PF16797.5 ETN98625.1 - 0.059 13.1 0.1 0.093 12.4 0.1 1.4 1 0 0 1 1 1 0 Fungal kinase associated-1 domain SHR-BD PF06650.12 ETN98626.1 - 3.7e-27 95.4 0.1 5.4e-27 94.8 0.1 1.3 1 0 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 DUF3883 PF13020.6 ETN98626.1 - 0.13 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) VWA_2 PF13519.6 ETN98627.1 - 4.6e-07 30.4 0.4 1.4e-06 28.9 0.4 1.9 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETN98627.1 - 0.0035 17.6 1.0 0.035 14.4 1.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain FAD_binding_8 PF08022.12 ETN98627.1 - 0.027 14.6 0.0 0.055 13.6 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain DUF5578 PF17741.1 ETN98627.1 - 0.15 11.4 0.0 4.3 6.7 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5578) DUF2543 PF10820.8 ETN98628.1 - 0.0035 17.5 0.1 0.0066 16.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2543) MA3 PF02847.17 ETN98628.1 - 0.0061 16.5 4.2 0.94 9.5 0.2 2.1 1 1 1 2 2 2 2 MA3 domain HEAT_2 PF13646.6 ETN98628.1 - 0.0063 16.9 0.0 0.0082 16.5 0.0 1.1 1 0 0 1 1 1 1 HEAT repeats OrfB_IS605 PF01385.19 ETN98628.1 - 0.1 12.8 0.2 0.14 12.4 0.2 1.2 1 0 0 1 1 1 0 Probable transposase WD40 PF00400.32 ETN98629.1 - 2.4e-16 59.8 14.6 2.9e-06 27.9 1.6 4.8 6 1 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98629.1 - 0.00037 20.7 0.7 2 8.8 0.1 3.7 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98629.1 - 0.003 16.3 3.1 0.68 8.5 0.0 3.6 1 1 1 4 4 4 3 Nucleoporin Nup120/160 zf-RRPl_C4 PF17026.5 ETN98631.1 - 0.054 13.6 1.1 0.054 13.6 1.1 2.1 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C3HC4_2 PF13923.6 ETN98631.1 - 1.1 9.1 8.0 1.3 8.9 4.5 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TPR_12 PF13424.6 ETN98632.1 - 1.5e-09 38.0 0.1 2.3e-09 37.4 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98632.1 - 6.1e-07 29.0 0.3 6.1e-07 29.0 0.3 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98632.1 - 2.8e-05 23.9 1.0 4.7e-05 23.2 0.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98632.1 - 9.2e-05 22.4 0.9 0.00022 21.2 0.9 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98632.1 - 0.00058 19.6 0.1 0.0033 17.3 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98632.1 - 0.0033 17.4 0.1 0.0072 16.3 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98632.1 - 0.0072 17.0 0.0 0.012 16.3 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat ATP-grasp_4 PF13535.6 ETN98632.1 - 0.012 15.2 1.7 0.55 9.8 0.1 2.3 2 0 0 2 2 2 0 ATP-grasp domain TPR_11 PF13414.6 ETN98632.1 - 0.017 14.8 0.1 0.044 13.5 0.1 1.7 1 0 0 1 1 1 0 TPR repeat DUF4865 PF16157.5 ETN98632.1 - 0.044 13.8 0.3 0.077 13.0 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4865) TPR_MalT PF17874.1 ETN98632.1 - 0.08 12.3 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 MalT-like TPR region Kelch_6 PF13964.6 ETN98633.1 - 0.0012 19.1 0.6 0.011 16.0 0.1 2.4 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN98633.1 - 0.0013 18.7 0.4 0.0046 16.9 0.0 1.9 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98633.1 - 0.04 13.5 0.1 0.35 10.5 0.0 2.1 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETN98633.1 - 0.065 13.5 0.0 0.2 12.0 0.0 1.8 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN98633.1 - 0.12 12.4 1.5 0.89 9.6 0.3 2.4 3 0 0 3 3 3 0 Kelch motif Allexi_40kDa PF05549.11 ETN98633.1 - 0.32 10.5 2.1 0.51 9.8 2.1 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein RVT_1 PF00078.27 ETN98635.1 - 1.4e-06 28.0 0.0 6e-06 25.9 0.0 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Piwi PF02171.17 ETN98636.1 - 5.8e-46 157.1 0.4 4e-45 154.4 0.0 1.9 1 1 1 2 2 2 1 Piwi domain TPR_12 PF13424.6 ETN98638.1 - 1.1e-56 189.1 2.5 1.1e-21 76.8 0.1 2.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98638.1 - 1.4e-33 113.8 0.0 3.8e-11 42.5 0.0 4.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98638.1 - 7.9e-28 94.4 0.9 4.2e-09 35.8 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98638.1 - 2.3e-27 93.7 20.8 5.5e-11 41.8 1.7 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98638.1 - 1.6e-24 84.0 21.5 3.9e-09 36.0 1.6 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98638.1 - 2.3e-23 80.4 11.6 1.4e-08 34.2 0.4 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98638.1 - 1.7e-12 46.8 8.7 0.00017 21.7 0.3 4.1 3 3 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98638.1 - 1.4e-09 37.5 23.9 0.00079 19.1 2.0 5.6 4 2 2 6 6 6 6 TPR repeat TPR_16 PF13432.6 ETN98638.1 - 3.5e-09 37.2 0.0 0.013 16.1 0.0 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98638.1 - 2.7e-07 30.8 0.5 0.46 11.2 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98638.1 - 1.6e-06 28.4 0.0 0.52 11.3 0.0 3.4 2 2 1 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETN98638.1 - 4.8e-06 25.9 0.1 0.0075 15.7 0.0 3.5 3 0 0 3 3 3 1 SHNi-TPR MIT PF04212.18 ETN98638.1 - 6.4e-06 26.1 8.7 0.07 13.2 0.2 3.2 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Mob_Pre PF01076.19 ETN98638.1 - 8.4e-05 22.5 0.1 0.00023 21.1 0.1 1.4 1 1 1 2 2 2 1 Plasmid recombination enzyme SNAP PF14938.6 ETN98638.1 - 0.00017 21.1 0.4 0.00077 19.0 0.4 1.9 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 ETN98638.1 - 0.00043 19.8 0.0 0.00047 19.6 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region Sel1 PF08238.12 ETN98638.1 - 0.00059 20.4 3.7 5.1 7.9 0.4 4.5 4 1 0 4 4 4 1 Sel1 repeat RPN7 PF10602.9 ETN98638.1 - 0.0017 18.1 1.8 0.39 10.4 0.1 2.3 1 1 1 2 2 2 2 26S proteasome subunit RPN7 DUF4810 PF16068.5 ETN98638.1 - 0.0018 18.8 0.5 3.2 8.4 0.0 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4810) ANAPC3 PF12895.7 ETN98638.1 - 0.0019 18.4 2.3 0.24 11.7 0.2 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETN98638.1 - 0.002 18.0 6.1 0.38 10.5 0.1 3.4 4 0 0 4 4 4 2 Domain of unknown function (DUF5113) PPR PF01535.20 ETN98638.1 - 0.0021 18.2 5.9 0.023 14.9 0.2 3.7 4 0 0 4 4 4 1 PPR repeat YecM PF06185.12 ETN98638.1 - 0.011 15.4 0.0 6 6.5 0.0 2.9 1 1 1 3 3 3 0 YecM protein TPR_3 PF07720.12 ETN98638.1 - 0.015 15.3 0.1 0.015 15.3 0.1 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat Phage_Treg PF04761.12 ETN98638.1 - 0.018 15.1 1.5 17 5.6 0.1 3.2 3 0 0 3 3 3 0 Lactococcus bacteriophage putative transcription regulator DUF2225 PF09986.9 ETN98638.1 - 0.025 14.3 1.0 1.5 8.5 0.9 2.1 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) ATP-synt_E_2 PF08112.11 ETN98638.1 - 0.026 14.8 10.5 1.9 8.8 0.1 3.3 2 1 1 3 3 3 0 ATP synthase epsilon subunit Y1_Tnp PF01797.16 ETN98638.1 - 0.034 14.3 0.8 4.3 7.5 0.1 2.5 1 1 2 3 3 3 0 Transposase IS200 like Ten1_2 PF15490.6 ETN98638.1 - 0.043 13.5 0.0 8.8 6.1 0.0 2.8 1 1 2 3 3 3 0 Telomere-capping, CST complex subunit TPR_19 PF14559.6 ETN98638.1 - 0.088 13.3 0.1 1.8 9.1 0.0 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat FATC PF02260.20 ETN98638.1 - 0.11 12.4 0.0 18 5.3 0.0 2.9 3 0 0 3 3 3 0 FATC domain Rota_NSP3 PF01665.16 ETN98638.1 - 0.12 11.5 3.3 2.9 6.9 0.2 2.5 1 1 2 3 3 3 0 Rotavirus non-structural protein NSP3 HTH_Bact PF18768.1 ETN98638.1 - 0.25 10.9 5.2 26 4.5 0.1 3.6 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain SPO22 PF08631.10 ETN98638.1 - 0.69 9.3 3.1 33 3.8 0.1 2.6 1 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like Fis1_TPR_C PF14853.6 ETN98638.1 - 5.7 7.1 8.5 11 6.2 0.3 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Cpn60_TCP1 PF00118.24 ETN98642.1 - 1.7e-37 129.2 0.0 2.3e-36 125.5 0.0 2.0 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family PolC_DP2 PF03833.13 ETN98642.1 - 0.048 11.5 0.1 0.072 11.0 0.1 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Spectrin PF00435.21 ETN98642.1 - 0.074 13.5 0.1 0.16 12.5 0.1 1.5 1 0 0 1 1 1 0 Spectrin repeat Phosducin PF02114.16 ETN98643.1 - 2.8e-06 26.5 0.0 4.7e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Phosducin Cwf_Cwc_15 PF04889.12 ETN98644.1 - 0.0056 16.5 13.7 0.0056 16.5 13.7 1.7 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.32 ETN98645.1 - 6.8e-17 61.5 12.7 3.2e-07 30.9 1.4 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN98645.1 - 1.3e-06 27.4 0.1 0.0049 15.6 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98645.1 - 2.9e-05 24.3 0.1 0.12 12.7 0.0 2.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETN98645.1 - 0.0035 16.9 2.9 0.0046 16.6 2.3 1.5 1 1 1 2 2 2 1 Domain of unknown function (DUF4221) TBCC PF07986.12 ETN98645.1 - 0.011 15.5 0.7 0.015 15.0 0.7 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor C WD40 PF00400.32 ETN98646.1 - 1.3e-10 41.7 12.6 3.1e-05 24.6 0.7 3.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Hph PF13694.6 ETN98646.1 - 0.00094 19.5 7.9 0.0014 18.9 7.9 1.3 1 0 0 1 1 1 1 Sec63/Sec62 complex-interacting family Lipoprotein_3 PF00938.17 ETN98646.1 - 0.038 14.2 2.3 0.073 13.3 2.3 1.5 1 0 0 1 1 1 0 Lipoprotein HBB PF06777.11 ETN98646.1 - 0.059 13.0 0.2 0.078 12.7 0.2 1.1 1 0 0 1 1 1 0 Helical and beta-bridge domain CorA PF01544.18 ETN98647.1 - 0.02 14.2 3.4 0.021 14.2 3.4 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUSP PF06337.12 ETN98647.1 - 7 7.3 11.3 10 6.8 11.3 1.5 1 1 0 1 1 1 0 DUSP domain Inhibitor_I29 PF08246.12 ETN98647.1 - 9.6 6.7 12.8 9.6 6.7 9.8 2.3 1 1 1 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) GNAT_acetyltr_2 PF13718.6 ETN98648.1 - 0.032 13.6 2.2 0.037 13.4 1.0 1.6 1 1 0 1 1 1 0 GNAT acetyltransferase 2 DUF3573 PF12097.8 ETN98648.1 - 0.2 10.4 4.4 0.28 10.0 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF5315 PF17242.2 ETN98648.1 - 0.25 11.2 0.3 0.25 11.2 0.3 2.5 2 0 0 2 2 2 0 Disordered region of unknown function (DUF5315) YPEB PF14620.6 ETN98648.1 - 0.34 10.2 7.6 0.45 9.8 7.6 1.1 1 0 0 1 1 1 0 YpeB sporulation Rab3-GTPase_cat PF13890.6 ETN98649.1 - 1.8e-07 30.9 0.9 3e-07 30.2 0.9 1.4 1 0 0 1 1 1 1 Rab3 GTPase-activating protein catalytic subunit zf-CCHC_4 PF14392.6 ETN98651.1 - 0.054 13.2 2.7 0.71 9.6 0.6 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 ETN98651.1 - 0.38 10.9 8.0 0.28 11.4 0.5 2.7 2 1 0 2 2 2 0 Zinc knuckle DUF2358 PF10184.9 ETN98652.1 - 0.03 14.6 0.4 0.085 13.1 0.0 2.0 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2358) DUF5128 PF17170.4 ETN98653.1 - 0.00096 18.4 4.2 0.0011 18.2 4.2 1.2 1 0 0 1 1 1 1 6-bladed beta-propeller BSMAP PF12280.8 ETN98654.1 - 0.022 15.0 0.2 0.022 15.0 0.2 1.1 1 0 0 1 1 1 0 Brain specific membrane anchored protein EMC3_TMCO1 PF01956.16 ETN98654.1 - 0.047 13.4 0.6 0.065 13.0 0.6 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Ring_hydroxyl_A PF00848.19 ETN98654.1 - 0.13 12.2 0.0 0.16 11.9 0.0 1.1 1 0 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) Zip PF02535.22 ETN98654.1 - 0.25 10.5 0.7 0.3 10.3 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETN98656.1 - 0.006 17.4 0.1 0.18 12.7 0.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat PUB PF09409.10 ETN98657.1 - 0.066 13.2 1.2 0.29 11.1 1.2 2.1 1 1 0 1 1 1 0 PUB domain WD40 PF00400.32 ETN98659.1 - 2.1e-07 31.5 12.7 0.0013 19.5 1.0 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98659.1 - 2.1e-05 23.4 0.4 0.0032 16.2 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ricin_B_lectin PF00652.22 ETN98659.1 - 0.014 15.6 4.6 0.018 15.3 4.6 1.1 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain CUE PF02845.16 ETN98660.1 - 0.039 13.7 0.1 0.12 12.1 0.1 1.9 1 0 0 1 1 1 0 CUE domain DUF1904 PF08921.11 ETN98660.1 - 0.1 12.9 3.0 0.11 12.8 0.3 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF1904) Mei5_like PF17021.5 ETN98661.1 - 0.013 15.5 3.0 0.065 13.3 1.9 2.1 1 1 1 2 2 2 0 Putative double-strand recombination repair-like SKA2 PF16740.5 ETN98661.1 - 0.019 14.8 0.4 0.027 14.3 0.4 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 IZUMO PF15005.6 ETN98661.1 - 0.14 12.7 1.3 0.18 12.3 1.3 1.1 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Kinesin PF00225.23 ETN98662.1 - 0.066 12.1 0.2 0.082 11.8 0.2 1.2 1 0 0 1 1 1 0 Kinesin motor domain PUB PF09409.10 ETN98663.1 - 9.8e-07 28.6 0.0 2.8e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 PUB domain DUF503 PF04456.12 ETN98663.1 - 0.022 14.6 0.3 0.048 13.5 0.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF503) ZZ PF00569.17 ETN98664.1 - 0.011 15.6 1.4 0.025 14.4 0.6 2.0 2 0 0 2 2 2 0 Zinc finger, ZZ type zf-4CXXC_R1 PF10497.9 ETN98664.1 - 0.02 15.1 1.3 0.038 14.2 1.3 1.4 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 TFIIIC_delta PF12657.7 ETN98664.1 - 0.083 12.8 0.1 0.22 11.4 0.2 1.8 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Fzo_mitofusin PF04799.13 ETN98664.1 - 0.47 10.0 5.0 1.5 8.3 4.5 2.1 2 0 0 2 2 2 0 fzo-like conserved region KxDL PF10241.9 ETN98664.1 - 0.55 10.6 10.6 2.8 8.3 0.2 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein Fib_alpha PF08702.10 ETN98664.1 - 2.7 8.2 12.9 1.4 9.1 0.2 3.3 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family FlxA PF14282.6 ETN98664.1 - 4.2 7.4 10.8 0.33 11.0 5.6 1.8 2 0 0 2 2 2 0 FlxA-like protein Exo_endo_phos_2 PF14529.6 ETN98665.1 - 5.9e-06 26.1 0.8 1.2e-05 25.1 0.8 1.6 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Kelch_2 PF07646.15 ETN98666.1 - 5.2e-05 23.0 0.3 0.0013 18.6 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETN98666.1 - 0.00042 20.5 0.0 0.0013 19.0 0.0 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98666.1 - 0.00085 18.9 1.2 0.0096 15.5 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN98666.1 - 0.0029 17.6 0.1 0.026 14.5 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN98666.1 - 0.0051 16.8 0.4 0.11 12.5 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN98666.1 - 0.04 14.2 2.5 0.8 10.1 0.3 2.5 1 1 1 2 2 2 0 Kelch motif IL3Ra_N PF18611.1 ETN98666.1 - 0.33 11.0 5.9 0.08 12.9 2.4 1.8 2 0 0 2 2 2 0 IL-3 receptor alpha chain N-terminal domain RNA_pol_Rpb5_C PF01191.19 ETN98667.1 - 0.038 13.8 0.3 0.065 13.1 0.3 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Nup54_57_C PF18570.1 ETN98667.1 - 0.14 11.8 0.2 0.14 11.8 0.2 2.8 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain Phos_pyr_kin PF08543.12 ETN98668.1 - 4e-12 46.1 0.0 5.4e-12 45.6 0.0 1.1 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase PfkB PF00294.24 ETN98668.1 - 9.1e-06 25.2 0.0 2e-05 24.1 0.0 1.5 2 0 0 2 2 2 1 pfkB family carbohydrate kinase Glyco_hydro_3_C PF01915.22 ETN98670.1 - 9.2e-14 51.9 0.0 1.3e-13 51.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain TPR_12 PF13424.6 ETN98671.1 - 2.1e-29 101.6 6.9 1.5e-17 63.6 0.6 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98671.1 - 6.3e-19 67.2 0.4 8e-08 31.9 0.1 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98671.1 - 7.7e-17 60.0 3.7 2.1e-05 24.2 0.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98671.1 - 7.1e-16 57.3 17.3 3.1e-08 33.1 3.7 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98671.1 - 3.3e-13 48.7 12.9 8.1e-05 22.4 0.7 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98671.1 - 1.9e-11 43.2 14.6 4.9e-07 29.5 2.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN98671.1 - 2.8e-07 30.7 1.5 0.14 12.8 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98671.1 - 3.1e-06 27.7 0.0 0.029 15.0 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98671.1 - 3.6e-05 23.8 7.5 0.068 13.6 0.4 3.1 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98671.1 - 3.8e-05 23.3 18.8 0.26 11.0 1.5 4.7 3 2 2 5 5 5 3 TPR repeat ANAPC3 PF12895.7 ETN98671.1 - 0.00013 22.1 2.9 0.0069 16.6 0.6 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETN98671.1 - 0.00016 22.2 0.1 4.4 8.4 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETN98671.1 - 0.00028 20.7 1.7 0.69 9.7 0.2 2.6 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) SPO22 PF08631.10 ETN98671.1 - 0.0004 20.0 0.6 0.002 17.7 0.1 1.9 1 1 1 2 2 2 1 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 ETN98671.1 - 0.0087 16.0 4.3 0.067 13.2 0.2 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat Dioxygenase_N PF04444.14 ETN98671.1 - 0.027 14.3 0.2 9 6.2 0.0 2.8 3 0 0 3 3 3 0 Catechol dioxygenase N terminus ATP-synt_E_2 PF08112.11 ETN98671.1 - 0.053 13.8 9.6 1 9.7 0.2 3.3 2 1 1 3 3 3 0 ATP synthase epsilon subunit CvfB_WH PF17783.1 ETN98671.1 - 0.059 13.2 0.5 10 6.0 0.1 2.3 2 0 0 2 2 2 0 CvfB-like winged helix domain TPR_MalT PF17874.1 ETN98671.1 - 0.065 12.6 0.0 0.066 12.6 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region Coq4 PF05019.13 ETN98671.1 - 0.11 11.8 0.0 0.14 11.5 0.0 1.3 1 1 0 1 1 1 0 Coenzyme Q (ubiquinone) biosynthesis protein Coq4 DUF2582 PF10771.9 ETN98671.1 - 0.17 12.0 1.3 1.4 9.2 0.1 2.2 2 0 0 2 2 2 0 Winged helix-turn-helix domain (DUF2582) DUF4795 PF16043.5 ETN98671.1 - 0.19 11.3 1.8 4.1 7.0 0.3 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) LMWSLP_N PF12211.8 ETN98671.1 - 0.4 10.3 3.6 0.41 10.2 0.9 1.8 1 1 1 2 2 2 0 Low molecular weight S layer protein N terminal Ubiq-assoc PF09145.10 ETN98671.1 - 2.9 8.0 7.8 0.81 9.7 0.5 3.3 2 1 3 5 5 5 0 Ubiquitin-associated SPRY PF00622.28 ETN98672.1 - 2.8e-07 30.7 0.2 4.9e-07 29.9 0.2 1.4 1 0 0 1 1 1 1 SPRY domain Tudor_4 PF18358.1 ETN98672.1 - 0.033 13.8 0.1 0.071 12.7 0.1 1.5 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain Cupin_3 PF05899.12 ETN98672.1 - 0.12 12.1 0.2 0.36 10.5 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF861) DUF5342 PF17277.2 ETN98672.1 - 3.9 7.9 5.2 2.4 8.6 0.3 3.0 4 0 0 4 4 4 0 Family of unknown function (DUF5342) AAA_5 PF07728.14 ETN98673.1 - 0.0048 16.9 0.0 0.023 14.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) DUF5069 PF16798.5 ETN98673.1 - 0.12 12.6 0.0 0.68 10.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5069) HSBP1 PF06825.12 ETN98674.1 - 0.034 14.0 0.9 0.073 12.9 0.9 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Zn_clus PF00172.18 ETN98675.1 - 0.011 15.9 1.6 0.018 15.1 1.6 1.4 1 0 0 1 1 1 0 Fungal Zn(2)-Cys(6) binuclear cluster domain Trp_dioxygenase PF03301.13 ETN98676.1 - 0.041 13.2 0.0 0.12 11.7 0.0 1.7 2 0 0 2 2 2 0 Tryptophan 2,3-dioxygenase DUF2431 PF10354.9 ETN98677.1 - 1.9e-05 25.0 0.5 2.3e-05 24.7 0.5 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) DUF4085 PF13315.6 ETN98677.1 - 0.03 14.0 0.3 0.043 13.4 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) DUF1980 PF09323.10 ETN98679.1 - 0.45 10.4 6.1 0.56 10.1 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Choline_sulf_C PF12411.8 ETN98680.1 - 0.0099 15.7 0.0 0.046 13.5 0.1 2.0 2 0 0 2 2 2 1 Choline sulfatase enzyme C terminal PA_decarbox PF05870.11 ETN98680.1 - 0.056 13.1 0.0 0.084 12.5 0.0 1.4 1 0 0 1 1 1 0 Phenolic acid decarboxylase (PAD) WD40 PF00400.32 ETN98682.1 - 0.001 19.8 0.0 0.0041 17.9 0.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF1924 PF09086.11 ETN98683.1 - 0.1 12.9 0.0 0.17 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1924) WD40 PF00400.32 ETN98684.1 - 3.3e-18 65.7 9.7 1.8e-06 28.6 0.3 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN98684.1 - 7.1e-05 21.7 1.0 2.1 6.9 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98684.1 - 0.001 19.3 0.0 0.071 13.4 0.0 2.7 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN98684.1 - 0.0021 16.9 2.1 0.0033 16.2 2.1 1.3 1 1 0 1 1 1 1 Nup133 N terminal like Read-through PF16814.5 ETN98684.1 - 0.0056 16.5 0.7 0.07 12.9 0.3 2.0 1 1 1 2 2 2 1 Read-through domain BBS2_Mid PF14783.6 ETN98684.1 - 0.015 15.3 0.8 0.082 12.9 0.1 2.2 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETN98687.1 - 1.5e-09 38.3 4.2 2.1e-05 25.2 0.5 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98687.1 - 0.0042 17.4 0.0 0.38 11.1 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98687.1 - 0.0072 15.0 0.1 0.95 8.0 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ank_3 PF13606.6 ETN98689.1 - 5.3e-08 32.5 0.8 5.4e-05 23.3 0.2 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ETN98689.1 - 4.6e-06 27.1 0.0 1.5e-05 25.5 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETN98689.1 - 7.1e-06 26.2 0.1 1.6e-05 25.1 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETN98689.1 - 2.4e-05 24.6 0.9 9.7e-05 22.7 0.2 2.4 2 0 0 2 2 2 1 Ankyrin repeat Med5 PF08689.10 ETN98689.1 - 0.0023 15.9 0.1 0.003 15.5 0.1 1.1 1 0 0 1 1 1 1 Mediator complex subunit Med5 Ank_4 PF13637.6 ETN98689.1 - 0.0045 17.5 0.4 0.013 16.0 0.4 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HU-DNA_bdg PF14848.6 ETN98689.1 - 0.048 13.7 0.3 0.093 12.7 0.3 1.4 1 0 0 1 1 1 0 DNA-binding domain UPF0172 PF03665.13 ETN98691.1 - 0.083 12.9 3.9 0.1 12.6 3.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) RNA_pol_Rpc4 PF05132.14 ETN98693.1 - 0.033 14.6 4.0 0.037 14.5 4.0 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 COPI_C PF06957.11 ETN98693.1 - 0.17 10.6 4.5 0.2 10.4 4.5 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus eIF-3c_N PF05470.12 ETN98693.1 - 0.19 10.0 4.8 0.22 9.8 4.8 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF913 PF06025.12 ETN98693.1 - 0.51 9.3 3.1 0.59 9.1 3.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETN98693.1 - 2.1 7.5 3.6 2.3 7.3 3.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ank_2 PF12796.7 ETN98695.1 - 1.7e-07 31.7 0.8 0.0081 16.7 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETN98695.1 - 4.4e-06 27.1 0.0 0.0071 16.9 0.0 4.0 4 0 0 4 4 4 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETN98695.1 - 6.7e-05 23.1 0.0 3.4 8.1 0.0 4.9 4 1 2 6 6 6 2 Ankyrin repeats (many copies) FAD_binding_6 PF00970.24 ETN98697.1 - 4.4e-23 81.5 0.0 1.4e-22 79.9 0.0 1.8 1 1 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ETN98697.1 - 3.8e-12 46.8 0.1 3.5e-11 43.7 0.0 2.5 2 1 1 3 3 3 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETN98697.1 - 2.7e-06 27.6 0.9 4.5e-06 26.9 0.2 1.7 2 0 0 2 2 2 1 Ferric reductase NAD binding domain TryThrA_C PF12319.8 ETN98698.1 - 0.00072 19.1 0.8 0.00072 19.1 0.8 2.1 2 0 0 2 2 2 2 Tryptophan-Threonine-rich plasmodium antigen C terminal EF-hand_6 PF13405.6 ETN98698.1 - 0.0011 18.7 0.1 0.0036 17.1 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ETN98698.1 - 0.0032 16.9 0.2 0.0078 15.7 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 ETN98698.1 - 0.0034 16.8 0.1 0.0087 15.6 0.1 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETN98698.1 - 0.006 17.0 0.2 0.011 16.1 0.2 1.6 1 1 0 1 1 1 1 EF-hand domain pair DEAD PF00270.29 ETN98699.1 - 0.00026 20.8 0.0 0.00098 18.9 0.0 1.7 1 1 1 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 ETN98699.1 - 0.025 14.1 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein ResIII PF04851.15 ETN98699.1 - 0.027 14.5 2.5 0.11 12.5 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETN98699.1 - 0.046 13.4 0.1 0.18 11.5 0.0 1.9 2 1 0 2 2 2 0 AAA domain TIP49 PF06068.13 ETN98699.1 - 0.06 12.5 0.0 0.097 11.9 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain K_channel_TID PF07941.11 ETN98699.1 - 1.6 9.2 11.5 1.9 9.0 2.9 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Ceramidse_alk_C PF17048.5 ETN98705.1 - 0.095 12.6 2.5 0.17 11.7 2.5 1.3 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, C-terminal Pneumo_M2 PF07380.11 ETN98705.1 - 0.31 11.3 0.2 0.31 11.3 0.2 2.5 3 0 0 3 3 3 0 Pneumovirus M2 protein PBP1_TM PF14812.6 ETN98708.1 - 0.0022 18.3 2.8 0.0022 18.3 2.8 1.8 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 ETN98708.1 - 0.081 12.6 0.9 0.11 12.1 0.9 1.2 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ETN98708.1 - 1.2 9.6 8.2 1.8 9.0 8.2 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Transketolase_N PF00456.21 ETN98709.1 - 0.05 12.6 0.2 0.081 11.9 0.2 1.3 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain HEAT_2 PF13646.6 ETN98710.1 - 0.00026 21.3 0.0 0.00052 20.3 0.0 1.5 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 ETN98710.1 - 0.0026 17.9 0.0 1.9 9.0 0.0 2.4 2 0 0 2 2 2 2 HEAT repeat HEAT PF02985.22 ETN98711.1 - 7.5e-17 60.0 0.1 0.037 14.3 0.0 5.6 5 0 0 5 5 5 5 HEAT repeat HEAT_2 PF13646.6 ETN98711.1 - 1e-13 51.5 0.0 0.0001 22.6 0.0 3.2 1 1 2 3 3 3 3 HEAT repeats Vac14_Fab1_bd PF12755.7 ETN98711.1 - 2.3e-12 47.4 1.4 0.0063 17.1 0.0 4.3 1 1 4 5 5 5 4 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETN98711.1 - 1.6e-08 34.7 1.0 7.9e-05 22.8 0.1 3.3 1 1 2 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETN98711.1 - 3.9e-08 33.5 5.3 0.0017 18.4 0.5 3.5 1 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETN98711.1 - 4.1e-07 29.9 5.9 0.087 12.6 0.1 4.0 1 1 4 5 5 5 3 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 ETN98711.1 - 6.6e-06 26.5 0.0 5.5 7.6 0.0 4.6 3 1 1 5 5 5 2 HEAT-like repeat NLE PF08154.12 ETN98711.1 - 0.00011 22.6 4.9 5.8 7.5 0.1 5.1 3 2 2 5 5 5 1 NLE (NUC135) domain Adaptin_N PF01602.20 ETN98711.1 - 0.0006 18.5 1.5 0.027 13.1 0.2 1.9 1 1 1 2 2 2 1 Adaptin N terminal region DrsE PF02635.15 ETN98711.1 - 0.0041 17.5 0.6 0.11 12.9 0.2 2.8 2 1 0 2 2 2 1 DsrE/DsrF-like family HTH_10 PF04967.12 ETN98711.1 - 0.013 15.3 0.0 6.7 6.6 0.0 3.7 3 1 1 4 4 4 0 HTH DNA binding domain ThiJ_like PF17124.5 ETN98711.1 - 0.017 14.8 0.0 0.33 10.6 0.0 2.4 2 1 0 2 2 2 0 ThiJ/PfpI family-like IFRD PF05004.13 ETN98711.1 - 0.017 14.2 1.3 4 6.5 0.9 3.0 1 1 2 3 3 3 0 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 ETN98711.1 - 0.022 14.3 0.1 5.4 6.5 0.0 2.3 1 1 1 2 2 2 0 CLASP N terminal T3RM_EcoP15I_C PF18273.1 ETN98711.1 - 0.027 14.8 5.5 21 5.5 0.2 4.7 1 1 4 5 5 5 0 Type III R-M EcoP15I C-terminal domain PL48 PF15903.5 ETN98711.1 - 0.041 12.8 0.1 3.3 6.6 0.0 3.1 1 1 3 4 4 4 0 Filopodia upregulated, FAM65 DUF3349 PF11829.8 ETN98711.1 - 0.064 14.0 4.8 20 6.0 0.3 4.8 3 1 4 7 7 5 0 Protein of unknown function (DUF3349) DUF1677 PF07911.13 ETN98711.1 - 0.073 13.5 0.9 4.9 7.6 0.2 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1677) FAM178 PF14816.6 ETN98711.1 - 0.089 11.8 0.4 1.6 7.7 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function, FAM178 DUF2487 PF10673.9 ETN98711.1 - 0.15 12.1 0.4 4.9 7.2 0.0 3.0 2 2 2 4 4 4 0 Protein of unknown function (DUF2487) Activator-TraM PF11657.8 ETN98711.1 - 0.19 11.6 1.2 0.77 9.6 0.0 2.5 3 1 0 3 3 3 0 Transcriptional activator TraM Inhibitor_I9 PF05922.16 ETN98711.1 - 0.53 11.0 1.8 54 4.5 0.0 3.2 3 0 0 3 3 3 0 Peptidase inhibitor I9 Imm30 PF15565.6 ETN98711.1 - 1.4 9.0 7.5 13 6.0 0.5 3.7 3 2 1 4 4 4 0 Immunity protein 30 Spore_Cse60 PF10957.8 ETN98711.1 - 3.7 7.6 6.5 62 3.7 0.1 4.0 3 1 1 4 4 4 0 Sporulation protein Cse60 AAA PF00004.29 ETN98712.1 - 0.0011 19.4 0.0 0.0027 18.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETN98712.1 - 0.0051 17.1 0.0 0.07 13.4 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 ETN98712.1 - 0.025 14.1 0.1 0.21 11.1 0.0 2.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_5 PF07728.14 ETN98712.1 - 0.13 12.3 0.1 2.3 8.2 0.1 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) TAF6_C PF07571.13 ETN98713.1 - 0.13 12.5 0.1 49 4.4 0.0 3.1 3 0 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain PqiA PF04403.13 ETN98716.1 - 0.056 13.3 1.1 0.93 9.3 0.2 2.1 2 0 0 2 2 2 0 Paraquat-inducible protein A ERAP1_C PF11838.8 ETN98717.1 - 7.6e-34 117.7 0.0 9.2e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain HEAT_2 PF13646.6 ETN98717.1 - 0.0046 17.3 0.0 0.0069 16.7 0.0 1.3 1 0 0 1 1 1 1 HEAT repeats AAA_18 PF13238.6 ETN98719.1 - 0.066 13.8 0.0 0.086 13.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain MRP-S25 PF13741.6 ETN98719.1 - 0.17 11.4 0.8 0.22 11.1 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein S25 RPN2_C PF18004.1 ETN98721.1 - 2.8e-09 37.1 10.0 4e-09 36.6 10.0 1.3 1 1 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PTP_tm PF18861.1 ETN98721.1 - 0.047 13.7 0.3 0.049 13.6 0.3 1.1 1 0 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DUF3987 PF13148.6 ETN98721.1 - 0.31 10.0 3.1 0.36 9.8 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Glyco_hydro_77 PF02446.17 ETN98723.1 - 0.019 13.8 0.2 0.028 13.3 0.2 1.3 1 0 0 1 1 1 0 4-alpha-glucanotransferase Cupin_8 PF13621.6 ETN98724.1 - 0.033 13.9 0.4 0.034 13.9 0.4 1.3 1 0 0 1 1 1 0 Cupin-like domain FtsX_ECD PF18075.1 ETN98724.1 - 0.053 14.1 3.4 0.46 11.1 0.1 2.5 2 1 1 3 3 3 0 FtsX extracellular domain UPF0121 PF03661.13 ETN98724.1 - 0.069 12.5 0.5 0.16 11.3 0.0 1.7 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0121) LCAT PF02450.15 ETN98726.1 - 0.011 14.9 1.0 0.056 12.6 0.2 2.0 2 0 0 2 2 2 0 Lecithin:cholesterol acyltransferase KIP1 PF07765.12 ETN98726.1 - 0.07 13.3 0.4 7.3 6.8 0.1 2.7 2 0 0 2 2 2 0 KIP1-like protein WD40 PF00400.32 ETN98727.1 - 5.5e-08 33.3 1.9 9.3e-07 29.5 0.4 2.9 2 1 0 2 2 2 1 WD domain, G-beta repeat SMYLE_N PF18615.1 ETN98730.1 - 0.36 10.3 11.6 0.44 10.1 11.6 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TMEM132 PF16070.5 ETN98730.1 - 2.4 7.4 8.5 9.5 5.4 6.6 2.2 1 1 1 2 2 2 0 Transmembrane protein family 132 Menin PF05053.13 ETN98730.1 - 4.7 5.4 18.3 6.4 5.0 18.3 1.2 1 0 0 1 1 1 0 Menin HCO3_cotransp PF00955.21 ETN98730.1 - 6.9 5.4 6.5 9.6 4.9 6.5 1.1 1 0 0 1 1 1 0 HCO3- transporter family SprA-related PF12118.8 ETN98730.1 - 9 5.3 21.8 12 4.9 21.8 1.2 1 0 0 1 1 1 0 SprA-related family U-box PF04564.15 ETN98731.1 - 2.5e-08 33.9 0.1 6.7e-08 32.6 0.1 1.8 1 1 0 1 1 1 1 U-box domain SAM_3 PF18016.1 ETN98731.1 - 0.059 13.2 1.8 0.09 12.6 0.3 2.1 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) Gpi1 PF05024.15 ETN98731.1 - 0.074 13.1 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) AI-2E_transport PF01594.16 ETN98731.1 - 0.38 9.9 0.7 0.53 9.4 0.7 1.2 1 0 0 1 1 1 0 AI-2E family transporter STAR_dimer PF16544.5 ETN98731.1 - 3 7.5 6.0 16 5.1 3.6 2.7 2 1 0 2 2 2 0 Homodimerisation region of STAR domain protein ArfGap PF01412.18 ETN98732.1 - 9.3e-08 32.2 0.0 2e-07 31.1 0.0 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 ETN98732.1 - 0.00074 20.0 6.1 0.11 13.0 0.8 3.4 2 2 0 2 2 2 2 PH domain TcdB_N PF12918.7 ETN98733.1 - 0.035 14.4 0.2 0.07 13.4 0.2 1.5 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain GLTSCR1 PF15249.6 ETN98733.1 - 1.5 9.3 4.6 0.46 11.0 1.5 1.6 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein ubiquitin PF00240.23 ETN98735.1 - 7.3e-69 227.5 5.0 9.4e-34 115.0 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETN98735.1 - 8.4e-35 118.4 5.7 8.6e-17 60.7 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETN98735.1 - 1.4e-13 51.1 1.3 4.1e-05 24.0 0.1 3.2 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 ETN98735.1 - 2.3e-09 37.0 0.8 0.0021 18.0 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETN98735.1 - 9.2e-09 35.4 0.3 0.0069 16.5 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETN98735.1 - 4.6e-08 33.3 0.9 0.01 16.2 0.1 2.1 2 0 0 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 ETN98735.1 - 8.4e-07 29.5 0.1 0.062 13.9 0.0 2.2 1 1 0 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETN98735.1 - 7e-06 26.0 6.6 3 8.0 0.7 4.0 2 2 0 2 2 2 2 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ETN98735.1 - 0.00032 20.6 0.0 0.79 9.5 0.0 2.1 2 0 0 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain PI3K_rbd PF00794.18 ETN98735.1 - 0.0024 18.0 0.4 1.5 9.0 0.0 2.4 2 0 0 2 2 2 2 PI3-kinase family, ras-binding domain DUF2870 PF11069.8 ETN98735.1 - 0.0063 16.9 0.5 11 6.5 0.0 3.3 2 2 2 4 4 4 0 Protein of unknown function (DUF2870) RBD PF02196.15 ETN98735.1 - 0.018 15.1 0.0 8.4 6.6 0.0 2.3 2 0 0 2 2 2 0 Raf-like Ras-binding domain eRF1_1 PF03463.15 ETN98735.1 - 0.022 14.8 0.3 3.1 7.8 0.1 2.4 1 1 0 2 2 2 0 eRF1 domain 1 USP7_C2 PF14533.6 ETN98735.1 - 0.038 13.7 0.3 7.6 6.2 0.0 2.1 2 0 0 2 2 2 0 Ubiquitin-specific protease C-terminal FERM_f0 PF16511.5 ETN98735.1 - 0.042 14.2 2.6 27 5.2 0.2 3.7 2 2 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM DUF5383 PF17355.2 ETN98735.1 - 0.078 13.4 1.5 11 6.4 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5383) TmoB PF06234.12 ETN98735.1 - 0.1 12.7 0.4 23 5.2 0.1 2.8 2 2 0 2 2 2 0 Toluene-4-monooxygenase system protein B (TmoB) FlgD_ig PF13860.6 ETN98735.1 - 0.13 12.2 0.3 24 4.9 0.0 2.4 2 0 0 2 2 2 0 FlgD Ig-like domain DUF969 PF06149.12 ETN98735.1 - 0.19 11.1 0.0 8.8 5.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF969) PI3K_p85B PF02192.16 ETN98735.1 - 0.26 11.0 0.7 26 4.6 0.1 2.4 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain EssA PF10661.9 ETN98736.1 - 0.00026 20.9 5.9 0.00026 20.9 5.9 2.4 2 1 1 3 3 3 1 WXG100 protein secretion system (Wss), protein EssA Jnk-SapK_ap_N PF09744.9 ETN98736.1 - 0.00031 21.0 5.2 0.00031 21.0 5.2 2.2 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 ADIP PF11559.8 ETN98736.1 - 0.002 18.3 4.6 0.002 18.3 4.6 2.2 2 1 0 2 2 2 1 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ETN98736.1 - 0.0021 18.3 4.8 0.0021 18.3 4.8 2.2 2 0 0 2 2 1 1 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 ETN98736.1 - 0.0041 16.6 5.1 0.0041 16.6 5.1 2.1 2 0 0 2 2 2 1 Golgin subfamily A member 5 Spc24 PF08286.11 ETN98736.1 - 0.011 16.0 14.0 0.14 12.4 0.6 3.2 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 DUF603 PF04645.12 ETN98736.1 - 0.022 14.5 3.7 0.041 13.6 3.7 1.5 1 1 0 1 1 1 0 Protein of unknown function, DUF603 HAUS-augmin3 PF14932.6 ETN98736.1 - 0.054 13.1 14.0 0.05 13.2 2.6 2.1 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 YMF19 PF02326.15 ETN98736.1 - 0.28 12.0 0.2 0.28 12.0 0.2 2.6 1 1 2 3 3 3 0 Plant ATP synthase F0 HR1 PF02185.16 ETN98736.1 - 1.2 9.3 19.0 1.2 9.3 7.7 3.4 2 1 1 3 3 3 0 Hr1 repeat Qua1 PF16274.5 ETN98736.1 - 1.3 8.9 5.8 0.2 11.5 0.7 2.5 2 1 1 3 3 3 0 Qua1 domain PRKG1_interact PF15898.5 ETN98736.1 - 1.4 9.9 18.6 0.33 11.9 2.8 3.1 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain Mt_ATP-synt_D PF05873.12 ETN98736.1 - 1.6 8.6 7.6 0.18 11.6 2.4 2.1 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) APG6_N PF17675.1 ETN98736.1 - 1.8 9.1 22.6 84 3.7 22.7 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETN98736.1 - 2.5 8.1 8.3 0.25 11.4 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 ETN98736.1 - 3.1 8.5 18.6 0.56 10.8 7.0 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3584 PF12128.8 ETN98736.1 - 3.2 5.2 15.7 0.0054 14.3 4.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) DUF1003 PF06210.11 ETN98736.1 - 3.4 7.8 8.9 0.31 11.1 3.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1003) DUF1640 PF07798.11 ETN98736.1 - 4.4 7.3 16.0 0.25 11.4 5.1 3.3 2 2 2 4 4 4 0 Protein of unknown function (DUF1640) TMPIT PF07851.13 ETN98736.1 - 6 6.0 11.3 1.6 7.9 3.8 2.2 2 0 0 2 2 2 0 TMPIT-like protein SLX9 PF15341.6 ETN98736.1 - 6.9 7.1 12.0 0.093 13.1 3.5 1.9 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 SlyX PF04102.12 ETN98736.1 - 8.7 7.0 14.7 6 7.6 1.2 3.4 2 2 1 3 3 3 0 SlyX DUF2714 PF10896.8 ETN98739.1 - 0.0027 17.7 0.2 0.0055 16.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2714) XS PF03468.14 ETN98739.1 - 0.035 14.4 0.1 0.073 13.4 0.1 1.5 1 0 0 1 1 1 0 XS domain Fmp27_SW PF10305.9 ETN98740.1 - 0.25 12.1 8.2 5.2 7.8 3.7 2.2 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain LMBR1 PF04791.16 ETN98740.1 - 2.3 7.1 4.5 0.69 8.7 1.9 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein DUF5355 PF17306.2 ETN98740.1 - 4.7 6.2 11.8 0.33 10.0 7.0 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5355) KASH_CCD PF14662.6 ETN98743.1 - 3.7e-05 23.6 68.1 0.0027 17.6 37.7 2.2 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH DUF16 PF01519.16 ETN98743.1 - 0.0004 20.8 67.6 0.34 11.4 17.0 4.8 1 1 5 6 6 6 4 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.12 ETN98743.1 - 0.00056 20.0 65.3 0.071 13.2 19.3 3.7 1 1 1 3 3 3 3 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 ETN98743.1 - 0.011 15.7 83.3 0.032 14.2 13.9 5.5 1 1 5 6 6 6 0 TATA element modulatory factor 1 DNA binding Seryl_tRNA_N PF02403.22 ETN98743.1 - 0.016 15.4 66.2 0.023 14.9 18.4 3.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 ETN98743.1 - 0.036 14.3 55.6 0.026 14.7 23.4 2.4 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 ETN98743.1 - 0.061 13.8 68.8 3.8 8.0 25.4 3.5 1 1 3 4 4 4 0 Apg6 coiled-coil region DivIC PF04977.15 ETN98743.1 - 0.12 12.2 73.5 0.31 10.8 8.4 5.9 1 1 5 6 6 6 0 Septum formation initiator SlyX PF04102.12 ETN98743.1 - 0.15 12.7 46.2 2.6 8.7 7.3 5.2 1 1 3 4 4 4 0 SlyX GAS PF13851.6 ETN98743.1 - 0.19 11.1 77.2 4.7 6.5 34.6 2.9 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding BLOC1_2 PF10046.9 ETN98743.1 - 0.3 11.4 60.1 2.7 8.4 4.3 5.2 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.15 ETN98743.1 - 0.3 11.5 55.3 0.74 10.2 22.1 2.1 1 1 1 2 2 2 0 Fez1 Fib_alpha PF08702.10 ETN98743.1 - 0.57 10.4 56.3 0.083 13.1 24.4 3.0 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family CHASE3 PF05227.13 ETN98743.1 - 0.59 10.1 29.8 0.94 9.4 1.7 4.5 1 1 3 4 4 4 0 CHASE3 domain zf-C4H2 PF10146.9 ETN98743.1 - 1.6 9.0 57.9 2.6 8.3 25.9 2.3 1 1 1 2 2 2 0 Zinc finger-containing protein HOOK PF05622.12 ETN98743.1 - 2.1 6.4 69.4 0.11 10.7 31.5 2.3 1 1 1 2 2 2 0 HOOK protein HIP1_clath_bdg PF16515.5 ETN98743.1 - 4.4 8.0 59.5 10 6.8 20.2 4.2 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ERM PF00769.19 ETN98743.1 - 6.3 6.5 60.6 4.9 6.9 36.6 2.1 1 1 1 2 2 2 0 Ezrin/radixin/moesin family Herpes_UL6 PF01763.16 ETN98743.1 - 7.7 4.9 47.5 2.8 6.3 14.3 3.5 1 1 2 3 3 3 0 Herpesvirus UL6 like Leu_zip PF15294.6 ETN98743.1 - 8.7 5.8 62.5 3.2 7.2 14.3 3.2 1 1 2 3 3 3 0 Leucine zipper WD40 PF00400.32 ETN98744.1 - 0.0016 19.2 1.0 18 6.4 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat Sec20 PF03908.13 ETN98744.1 - 0.046 13.6 9.5 0.45 10.5 4.9 2.9 2 0 0 2 2 2 0 Sec20 HSP70 PF00012.20 ETN98745.1 - 0.00036 18.9 0.0 0.0066 14.7 0.0 2.1 2 0 0 2 2 2 2 Hsp70 protein BcrAD_BadFG PF01869.20 ETN98745.1 - 0.15 11.5 0.0 0.28 10.7 0.0 1.4 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DDR PF08841.10 ETN98745.1 - 0.2 10.6 0.1 0.31 10.0 0.1 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain VWA_2 PF13519.6 ETN98747.1 - 0.033 14.8 0.0 0.05 14.2 0.0 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain HSP70 PF00012.20 ETN98748.1 - 0.026 12.7 0.0 0.069 11.3 0.0 1.5 1 1 0 1 1 1 0 Hsp70 protein FANCI_HD1 PF14679.6 ETN98748.1 - 0.12 12.3 0.2 1 9.4 0.0 2.3 2 0 0 2 2 2 0 FANCI helical domain 1 WD40 PF00400.32 ETN98750.1 - 3.6e-54 179.5 20.0 1.5e-10 41.5 0.1 6.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98750.1 - 9.8e-25 86.7 3.4 0.00042 20.6 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98750.1 - 1.3e-13 50.7 0.0 0.0044 16.0 0.0 5.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN98750.1 - 4.3e-12 46.0 1.7 0.00031 20.2 0.3 4.3 2 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETN98750.1 - 7.6e-08 31.4 5.7 0.083 11.5 0.1 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETN98750.1 - 3e-05 24.1 1.6 2.3 8.3 0.1 4.3 1 1 4 5 5 5 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETN98750.1 - 3.5e-05 22.5 0.4 0.46 9.0 0.0 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETN98750.1 - 0.00017 20.7 3.7 7.9 5.3 0.0 4.0 2 1 1 4 4 4 3 Partner and localizer of BRCA2 WD40 domain DUF5474 PF17568.2 ETN98750.1 - 0.0026 17.8 1.5 2.5 8.3 0.0 3.7 2 1 2 4 4 4 1 Family of unknown function (DUF5474) PQQ PF01011.21 ETN98750.1 - 0.013 15.4 0.0 2.5 8.2 0.1 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat DPPIV_N PF00930.21 ETN98750.1 - 0.017 13.9 0.1 2.5 6.8 0.0 3.3 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETN98750.1 - 0.043 13.8 1.2 46 4.1 0.2 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Hint PF01079.20 ETN98750.1 - 0.07 12.6 0.1 18 4.7 0.0 2.9 3 0 0 3 3 3 0 Hint module DUF5449 PF17528.2 ETN98750.1 - 0.072 12.8 0.1 0.98 9.2 0.0 2.5 1 1 1 3 3 3 0 Family of unknown function (DUF5449) MCM PF00493.23 ETN98751.1 - 2.1e-85 285.4 1.0 3.1e-85 284.8 1.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETN98751.1 - 1.3e-26 92.9 0.5 2.7e-26 91.9 0.5 1.5 1 0 0 1 1 1 1 MCM OB domain Mg_chelatase PF01078.21 ETN98751.1 - 4.9e-07 29.3 0.1 0.00012 21.6 0.0 2.5 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETN98751.1 - 0.0093 15.8 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ETN98751.1 - 0.013 16.0 0.1 0.039 14.4 0.1 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETN98751.1 - 0.024 14.4 0.1 0.081 12.6 0.1 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain TPR_1 PF00515.28 ETN98752.1 - 6.2e-05 22.6 0.2 0.00022 20.9 0.1 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98752.1 - 0.00018 21.1 1.2 0.00021 20.9 0.1 1.7 2 0 0 2 2 2 1 TPR repeat TPR_2 PF07719.17 ETN98752.1 - 0.0029 17.6 0.1 0.0065 16.5 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98752.1 - 0.069 13.4 1.2 0.12 12.6 0.1 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.25 ETN98753.1 - 2.6e-40 138.4 0.0 3.9e-40 137.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98753.1 - 3.6e-15 55.9 0.0 5.8e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETN98753.1 - 1.2e-05 24.8 0.0 2.1e-05 24.0 0.0 1.3 1 1 0 1 1 1 1 Kinase-like PEPcase PF00311.17 ETN98753.1 - 0.067 11.3 0.3 0.092 10.8 0.3 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Seadorna_VP7 PF07387.11 ETN98753.1 - 0.097 11.7 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 LIF_OSM PF01291.17 ETN98755.1 - 0.025 14.8 0.1 0.055 13.6 0.1 1.5 1 1 0 1 1 1 0 LIF / OSM family SapB_2 PF03489.17 ETN98755.1 - 0.11 12.6 0.1 1.7 8.9 0.0 2.5 2 0 0 2 2 2 0 Saposin-like type B, region 2 Ank_5 PF13857.6 ETN98756.1 - 0.15 12.5 0.0 23 5.4 0.0 3.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) PCRF PF03462.18 ETN98756.1 - 1.4 8.7 5.1 1.9 8.3 0.5 2.8 2 0 0 2 2 2 0 PCRF domain CNOT11 PF10155.9 ETN98756.1 - 6 7.0 8.5 31 4.7 0.0 4.6 5 0 0 5 5 5 0 CCR4-NOT transcription complex subunit 11 VIT1 PF01988.19 ETN98757.1 - 1.6e-62 211.2 1.5 1.8e-62 211.0 1.5 1.0 1 0 0 1 1 1 1 VIT family BON PF04972.17 ETN98758.1 - 1.3e-32 111.9 6.4 8.5e-19 67.6 1.6 2.2 2 0 0 2 2 2 2 BON domain EFG_C PF00679.24 ETN98758.1 - 0.055 13.5 0.0 8 6.6 0.0 2.3 2 0 0 2 2 2 0 Elongation factor G C-terminus DUF3194 PF11419.8 ETN98758.1 - 0.34 11.3 4.9 1.2 9.6 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3194) DUF5342 PF17277.2 ETN98759.1 - 0.021 15.2 0.2 0.046 14.1 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5342) RGS PF00615.19 ETN98760.1 - 1.7e-07 31.5 0.2 6.7e-07 29.6 0.0 2.1 2 1 0 2 2 2 1 Regulator of G protein signaling domain DUF3916 PF13079.6 ETN98760.1 - 0.043 13.7 0.0 0.13 12.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3916) MAP17 PF15807.5 ETN98763.1 - 3.4 7.9 10.0 8.9 6.6 10.0 1.7 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Leu_zip PF15294.6 ETN98766.1 - 0.00028 20.5 9.5 0.0003 20.4 9.5 1.1 1 0 0 1 1 1 1 Leucine zipper TMCO5 PF14992.6 ETN98766.1 - 0.0011 18.6 14.0 0.0012 18.4 14.0 1.0 1 0 0 1 1 1 1 TMCO5 family UPF0449 PF15136.6 ETN98766.1 - 0.0051 17.2 9.8 0.0075 16.7 9.8 1.3 1 0 0 1 1 1 1 Uncharacterised protein family UPF0449 DUF1465 PF07323.12 ETN98766.1 - 0.0086 15.9 5.1 0.011 15.6 5.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1465) Cauli_AT PF03233.13 ETN98766.1 - 0.0087 16.0 7.9 0.01 15.8 7.9 1.2 1 0 0 1 1 1 1 Aphid transmission protein CENP-R PF06729.12 ETN98766.1 - 0.014 15.3 7.6 0.02 14.8 7.2 1.4 1 1 0 1 1 1 0 Kinetochore component, CENP-R Prominin PF05478.11 ETN98766.1 - 0.026 12.5 9.5 0.03 12.3 9.5 1.0 1 0 0 1 1 1 0 Prominin Spc7 PF08317.11 ETN98766.1 - 0.041 12.8 13.7 0.052 12.4 13.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein UPF0242 PF06785.11 ETN98766.1 - 0.046 13.8 12.1 0.052 13.6 12.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ERM PF00769.19 ETN98766.1 - 0.046 13.5 18.0 0.048 13.5 18.0 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SlyX PF04102.12 ETN98766.1 - 0.057 14.0 3.6 0.057 14.0 3.6 2.2 1 1 1 2 2 2 0 SlyX PA26 PF04636.13 ETN98766.1 - 0.16 10.9 11.0 0.18 10.7 11.0 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2730 PF10805.8 ETN98766.1 - 0.17 12.0 4.7 0.22 11.6 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) TraH PF06122.11 ETN98766.1 - 0.2 10.9 4.8 0.23 10.7 4.8 1.0 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein SprA-related PF12118.8 ETN98766.1 - 0.24 10.5 14.1 0.27 10.3 14.1 1.0 1 0 0 1 1 1 0 SprA-related family KIAA1430 PF13879.6 ETN98766.1 - 0.4 11.5 18.3 22 5.9 18.3 2.1 1 1 0 1 1 1 0 KIAA1430 homologue FapA PF03961.13 ETN98766.1 - 0.44 9.1 11.9 0.49 8.9 11.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_11 PF13086.6 ETN98766.1 - 0.5 10.1 12.1 0.6 9.9 12.1 1.1 1 0 0 1 1 1 0 AAA domain FliD_N PF02465.18 ETN98766.1 - 0.53 11.0 7.1 0.71 10.6 7.1 1.3 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF2205 PF10224.9 ETN98766.1 - 0.56 10.2 13.3 1 9.4 10.0 2.3 1 1 1 2 2 2 0 Short coiled-coil protein GrpE PF01025.19 ETN98766.1 - 0.57 9.8 13.7 0.76 9.4 13.7 1.3 1 0 0 1 1 1 0 GrpE LCD1 PF09798.9 ETN98766.1 - 0.68 8.4 13.1 0.74 8.3 13.1 1.0 1 0 0 1 1 1 0 DNA damage checkpoint protein HemX PF04375.14 ETN98766.1 - 0.86 8.8 12.2 1 8.6 12.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TMPIT PF07851.13 ETN98766.1 - 1.1 8.5 10.8 1.2 8.3 10.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4337 PF14235.6 ETN98766.1 - 1.1 9.4 14.2 1.4 9.0 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DivIC PF04977.15 ETN98766.1 - 1.3 8.8 17.9 2.4 8.0 14.4 2.5 1 1 2 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 ETN98766.1 - 1.5 8.1 9.6 1.6 8.0 9.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XhlA PF10779.9 ETN98766.1 - 1.9 8.8 11.6 0.98 9.7 9.4 1.7 1 1 1 2 2 2 0 Haemolysin XhlA DUF3450 PF11932.8 ETN98766.1 - 1.9 7.7 12.5 2.7 7.2 12.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) LMBR1 PF04791.16 ETN98766.1 - 3.6 6.4 11.0 3.9 6.3 11.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4140 PF13600.6 ETN98766.1 - 5.1 7.6 9.3 9.2 6.8 8.9 1.8 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) V_ATPase_I PF01496.19 ETN98766.1 - 8.4 4.2 11.6 8.5 4.2 11.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WD40 PF00400.32 ETN98768.1 - 1.6e-47 158.5 3.3 3.8e-10 40.2 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98768.1 - 7.5e-17 61.4 1.3 0.049 13.9 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98768.1 - 6.8e-10 38.4 0.3 0.41 9.6 0.0 5.5 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN98768.1 - 3.5e-09 36.4 5.2 0.00026 20.4 0.4 3.6 2 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETN98768.1 - 4.1e-08 32.2 0.0 0.00016 20.4 0.0 2.5 2 1 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 ETN98768.1 - 4.7e-08 33.1 1.2 0.0034 17.3 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETN98768.1 - 5.9e-05 22.9 5.3 1.9 8.5 0.0 6.1 6 1 0 6 6 6 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETN98768.1 - 0.00088 18.4 1.3 0.011 14.8 0.1 2.0 1 1 0 2 2 2 1 Coatomer WD associated region PQQ PF01011.21 ETN98768.1 - 0.009 15.9 0.0 3.8 7.6 0.0 3.5 3 0 0 3 3 3 1 PQQ enzyme repeat Str_synth PF03088.16 ETN98768.1 - 0.0096 16.0 0.1 42 4.3 0.0 4.6 4 2 1 5 5 5 0 Strictosidine synthase SBD PF17882.1 ETN98768.1 - 0.013 15.4 0.0 2.4 8.0 0.0 3.3 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain DUF5570 PF17731.1 ETN98768.1 - 0.017 15.2 0.0 15 5.7 0.0 4.3 3 1 2 5 5 5 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETN98768.1 - 0.021 13.6 4.2 0.67 8.6 1.5 3.4 1 1 2 3 3 3 0 Nup133 N terminal like Proteasome_A_N PF10584.9 ETN98768.1 - 0.11 12.3 0.4 64 3.4 0.0 3.9 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETN98769.1 - 5.3e-62 204.3 19.3 9e-12 45.3 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98769.1 - 3.7e-33 113.7 0.0 2.8e-05 24.3 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETN98769.1 - 1.6e-14 54.2 0.0 0.00036 20.5 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETN98769.1 - 1.1e-13 51.3 0.0 1.5e-05 24.5 0.0 4.0 1 1 4 5 5 5 5 WD40-like domain PQQ_2 PF13360.6 ETN98769.1 - 6.4e-10 39.0 1.2 1.3e-05 24.9 0.1 2.6 1 1 0 2 2 2 2 PQQ-like domain Ge1_WD40 PF16529.5 ETN98769.1 - 1.7e-09 37.1 0.0 0.23 10.4 0.0 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN98769.1 - 4.8e-09 35.9 3.2 5.9 7.0 0.1 5.4 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETN98769.1 - 3.3e-07 29.9 0.0 3 8.0 0.0 5.6 6 0 0 6 6 6 1 PQQ enzyme repeat GspH PF12019.8 ETN98769.1 - 3.5e-07 30.6 3.4 0.85 10.1 0.1 4.2 2 2 2 4 4 4 3 Type II transport protein GspH Nup160 PF11715.8 ETN98769.1 - 4.5e-06 25.6 1.1 1.3 7.5 0.0 4.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Gmad1 PF10647.9 ETN98769.1 - 1.1e-05 25.3 0.0 0.89 9.3 0.0 4.4 2 1 0 3 3 3 2 Lipoprotein LpqB beta-propeller domain DUF4072 PF13284.6 ETN98769.1 - 1.5e-05 25.3 0.0 17 5.9 0.0 5.8 6 0 0 6 6 6 0 Domain of unknown function (DUF4072) Cytochrom_D1 PF02239.16 ETN98769.1 - 2e-05 23.3 1.1 0.27 9.7 0.1 3.4 1 1 2 3 3 3 3 Cytochrome D1 heme domain Frtz PF11768.8 ETN98769.1 - 8.1e-05 21.1 0.0 0.21 9.9 0.0 3.4 1 1 3 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETN98769.1 - 0.0045 17.1 9.9 6.8 6.8 0.1 4.9 1 1 4 5 5 5 1 Family of unknown function (DUF5570) DUF3509 PF12021.8 ETN98769.1 - 0.0091 15.7 0.1 0.31 10.8 0.0 3.2 3 2 1 4 4 4 1 Protein of unknown function (DUF3509) NYD-SP28_assoc PF14775.6 ETN98769.1 - 0.025 14.7 0.1 37 4.5 0.0 4.4 5 0 0 5 5 5 0 Sperm tail C-terminal domain Proteasome_A_N PF10584.9 ETN98769.1 - 0.029 14.1 13.9 38 4.1 0.1 5.9 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PH_TFIIH PF08567.11 ETN98769.1 - 0.064 13.6 1.8 93 3.5 0.0 4.3 5 0 0 5 5 5 0 TFIIH p62 subunit, N-terminal domain DUF3475 PF11961.8 ETN98769.1 - 0.067 13.3 0.3 0.42 10.7 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) FLgD_tudor PF13861.6 ETN98769.1 - 0.14 12.4 2.9 25 5.2 0.0 4.1 3 2 0 4 4 4 0 FlgD Tudor-like domain GP41 PF00517.17 ETN98771.1 - 5 7.0 9.9 2.2 8.1 6.4 2.1 1 1 1 2 2 2 0 Retroviral envelope protein Kelch_2 PF07646.15 ETN98772.1 - 5.3e-07 29.4 0.7 7.8e-05 22.5 0.4 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN98772.1 - 3.4e-06 27.0 0.5 0.021 14.8 0.2 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN98772.1 - 0.00016 21.2 4.3 0.0077 15.8 0.6 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETN98772.1 - 0.00017 21.7 2.0 0.058 13.7 0.2 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETN98772.1 - 0.00096 19.4 1.6 0.073 13.4 0.1 2.8 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN98772.1 - 0.033 14.2 3.1 1.7 8.7 0.0 2.8 2 1 0 2 2 2 0 Kelch motif YrpD PF15493.6 ETN98773.1 - 0.033 14.0 1.3 0.042 13.7 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function, YrpD Bacteriocin_IIi PF11758.8 ETN98773.1 - 0.044 13.6 0.5 0.35 10.7 0.1 2.3 2 0 0 2 2 2 0 Aureocin-like type II bacteriocin CRISPR_Cas2 PF09827.9 ETN98774.1 - 0.043 14.0 0.1 0.061 13.5 0.1 1.4 1 1 0 1 1 1 0 CRISPR associated protein Cas2 Cys_rich_VLP PF14194.6 ETN98774.1 - 0.12 12.6 0.1 0.17 12.0 0.1 1.3 1 0 0 1 1 1 0 Cysteine-rich VLP DUF4698 PF15769.5 ETN98775.1 - 0.029 13.4 3.2 0.034 13.2 3.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) ANAPC1 PF12859.7 ETN98775.1 - 0.1 13.2 2.1 0.14 12.7 2.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 Secretin_N_2 PF07655.13 ETN98775.1 - 0.77 10.3 22.2 0.38 11.3 19.9 1.7 2 0 0 2 2 2 0 Secretin N-terminal domain DUF1053 PF06327.14 ETN98777.1 - 0.037 14.6 2.7 0.31 11.6 0.6 2.2 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1053) BBS2_C PF14782.6 ETN98779.1 - 0.009 14.8 0.7 0.0092 14.8 0.7 1.0 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal Aida_N PF08910.10 ETN98779.1 - 0.028 14.8 0.4 0.04 14.3 0.4 1.3 1 0 0 1 1 1 0 Aida N-terminus FAP206 PF12018.8 ETN98780.1 - 0.024 14.2 10.6 0.03 13.8 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function CODH_A_N PF18537.1 ETN98780.1 - 0.56 10.3 2.2 16 5.6 0.3 2.6 1 1 1 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain IL17R_fnIII_D2 PF16578.5 ETN98780.1 - 0.68 10.5 6.5 9.9 6.7 1.7 2.5 1 1 1 2 2 2 0 Interleukin 17 receptor D PID PF00640.23 ETN98780.1 - 1.1 9.3 7.4 2.4 8.2 7.4 1.7 1 1 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) Pex14_N PF04695.13 ETN98780.1 - 5.1 7.7 12.8 5.6 7.6 11.9 1.6 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cnd1 PF12717.7 ETN98781.1 - 0.0008 19.5 7.3 0.22 11.6 0.3 3.4 1 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETN98781.1 - 0.0051 17.2 0.0 2.3 8.7 0.0 3.0 2 1 1 3 3 3 2 HEAT repeats FPL PF09758.9 ETN98781.1 - 0.012 15.6 1.8 7.3 6.6 0.1 3.2 2 1 1 3 3 3 0 Uncharacterised conserved protein Ribosomal_L22 PF00237.19 ETN98781.1 - 0.026 14.8 0.9 12 6.2 0.0 3.4 3 1 0 3 3 3 0 Ribosomal protein L22p/L17e HEAT PF02985.22 ETN98781.1 - 0.032 14.5 0.0 21 5.7 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat Thioredoxin_12 PF18400.1 ETN98782.1 - 0.0034 17.3 0.1 0.0055 16.6 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin-like domain AAA_7 PF12775.7 ETN98782.1 - 0.0053 16.3 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETN98782.1 - 0.0068 16.8 0.1 0.042 14.3 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETN98782.1 - 0.032 14.3 0.0 0.15 12.1 0.0 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETN98782.1 - 0.065 13.5 0.0 0.65 10.3 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETN98782.1 - 0.19 12.1 0.3 0.95 9.8 0.3 2.1 1 1 0 1 1 1 0 AAA domain VWA PF00092.28 ETN98784.1 - 2.4e-05 24.7 0.1 2.9e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETN98784.1 - 0.015 15.9 0.0 0.021 15.4 0.0 1.4 1 0 0 1 1 1 0 von Willebrand factor type A domain DUF5373 PF17343.2 ETN98785.1 - 0.0024 17.7 0.8 0.004 17.0 0.8 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5373) DUF5373 PF17343.2 ETN98786.1 - 0.0011 18.9 0.9 0.0012 18.7 0.9 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5373) Peptidase_C41 PF05417.11 ETN98786.1 - 0.098 12.5 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 Hepatitis E cysteine protease Kelch_1 PF01344.25 ETN98787.1 - 0.00024 20.6 0.3 0.0041 16.7 0.2 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETN98787.1 - 0.0021 18.0 0.3 0.053 13.5 0.3 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN98787.1 - 0.0028 17.6 0.0 0.0082 16.1 0.0 1.9 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN98787.1 - 0.15 12.1 1.5 0.86 9.7 0.1 2.7 3 1 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETN98787.1 - 0.16 12.3 0.0 0.53 10.6 0.0 1.9 1 0 0 1 1 1 0 Galactose oxidase, central domain TSP9 PF11493.8 ETN98788.1 - 0.4 11.4 0.0 0.4 11.4 0.0 2.1 2 1 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 ArAE_2_N PF10337.9 ETN98788.1 - 5.6 5.9 8.0 6.3 5.7 8.0 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal DUF3276 PF11680.8 ETN98789.1 - 0.27 11.4 5.4 0.24 11.5 4.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3276) ThiS-like PF14453.6 ETN98789.1 - 0.37 10.9 6.1 1.5 8.9 0.9 2.8 3 0 0 3 3 3 0 ThiS-like ubiquitin Guanylate_cyc PF00211.20 ETN98790.1 - 9.1e-08 31.9 0.1 1.3e-07 31.4 0.1 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3522 PF12036.8 ETN98790.1 - 0.0072 16.6 3.6 0.011 16.0 3.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Guanylate_cyc PF00211.20 ETN98791.1 - 2.3e-26 92.5 1.0 2.3e-26 92.5 1.0 1.9 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Renin_r PF07850.14 ETN98792.1 - 0.019 15.6 0.4 0.33 11.6 0.0 2.3 2 0 0 2 2 2 0 Renin receptor-like protein NOA36 PF06524.12 ETN98793.1 - 0.0038 16.6 6.3 0.0048 16.3 6.3 1.2 1 0 0 1 1 1 1 NOA36 protein Phage_holin_3_6 PF07332.11 ETN98793.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III TPR_12 PF13424.6 ETN98794.1 - 2.7e-16 59.6 4.1 8.3e-09 35.6 0.1 2.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98794.1 - 1.3e-08 34.4 0.4 3.1e-06 26.8 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98794.1 - 8.2e-07 28.6 4.8 8.5e-06 25.4 0.5 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98794.1 - 9e-07 28.5 4.7 0.0019 18.2 0.3 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98794.1 - 1.2e-06 28.3 6.0 0.0012 18.9 0.4 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98794.1 - 4e-06 26.5 0.5 2.8e-05 23.8 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN98794.1 - 0.00022 20.8 3.4 0.058 13.1 0.2 2.9 3 0 0 3 3 3 2 TPR repeat TPR_3 PF07720.12 ETN98794.1 - 0.012 15.6 0.4 0.031 14.3 0.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98794.1 - 0.024 15.4 0.0 1.9 9.5 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 ETN98794.1 - 0.086 12.9 0.2 0.17 11.9 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF627) ubiquitin PF00240.23 ETN98795.1 - 5.2e-14 51.7 3.0 2.5e-13 49.6 0.1 2.4 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.8 ETN98795.1 - 1.3e-05 25.0 0.1 1.3e-05 25.0 0.1 1.5 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ART PF01129.18 ETN98796.1 - 0.041 13.2 0.0 0.075 12.3 0.0 1.3 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase Tubulin PF00091.25 ETN98797.1 - 9e-08 32.5 0.1 1.6e-07 31.7 0.1 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain SWIRM PF04433.17 ETN98800.1 - 0.079 13.3 0.1 0.38 11.1 0.0 2.2 2 1 0 2 2 2 0 SWIRM domain Macoilin PF09726.9 ETN98800.1 - 0.23 10.0 11.9 0.28 9.7 11.9 1.1 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 ETN98800.1 - 3.6 5.6 8.6 4.2 5.4 8.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM220 PF15487.6 ETN98800.1 - 8.8 5.9 12.5 11 5.6 11.8 1.5 1 1 0 1 1 1 0 FAM220 family VPS13_C PF16909.5 ETN98801.1 - 0.00096 19.0 0.6 0.0016 18.2 0.0 1.7 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal DUF3015 PF11220.8 ETN98801.1 - 0.083 12.8 0.2 1.8 8.4 0.0 2.5 2 1 0 3 3 3 0 Protein of unknown function (DUF3015) PMSR PF01625.21 ETN98803.1 - 0.027 14.7 0.4 0.04 14.1 0.2 1.4 1 1 0 1 1 1 0 Peptide methionine sulfoxide reductase zf-C3HC4_2 PF13923.6 ETN98806.1 - 0.0035 17.1 1.2 0.08 12.8 0.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) TFIID_NTD2 PF04494.15 ETN98806.1 - 0.0038 17.5 2.3 0.006 16.8 2.3 1.4 1 0 0 1 1 1 1 WD40 associated region in TFIID subunit, NTD2 domain zf-RING_2 PF13639.6 ETN98806.1 - 0.008 16.5 0.4 0.85 10.0 0.0 2.3 2 0 0 2 2 2 1 Ring finger domain zf-met PF12874.7 ETN98806.1 - 0.017 15.5 1.3 0.035 14.5 1.3 1.5 1 0 0 1 1 1 0 Zinc-finger of C2H2 type zf-rbx1 PF12678.7 ETN98806.1 - 0.025 14.8 0.1 0.73 10.2 0.0 2.3 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ETN98806.1 - 0.041 13.7 1.4 3.3 7.6 0.1 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Prok-RING_4 PF14447.6 ETN98806.1 - 0.048 13.5 1.0 8.5 6.3 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETN98806.1 - 0.053 13.4 1.1 5.4 7.0 0.2 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Dna2 PF08696.11 ETN98807.1 - 1.1e-15 58.0 2.8 7.3e-08 32.5 0.3 2.7 1 1 1 2 2 2 2 DNA replication factor Dna2 TssD PF17642.1 ETN98809.1 - 0.023 14.5 2.0 0.026 14.3 2.0 1.2 1 0 0 1 1 1 0 Hemolysin coregulated protein Hcp (TssD) LssY_C PF14067.6 ETN98810.1 - 0.00093 18.8 0.0 0.0015 18.1 0.0 1.3 1 1 0 1 1 1 1 LssY C-terminus Baculo_IE-1 PF05290.11 ETN98810.1 - 0.09 12.7 0.3 0.09 12.7 0.3 1.7 2 1 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) Kelch_6 PF13964.6 ETN98811.1 - 0.0053 17.0 4.9 2 8.8 0.0 4.8 5 1 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETN98811.1 - 0.0089 16.0 0.2 0.3 11.1 0.0 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF2415 PF10313.9 ETN98811.1 - 0.069 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) Kelch_2 PF07646.15 ETN98811.1 - 0.1 12.6 0.3 11 6.2 0.0 3.5 3 1 0 3 3 3 0 Kelch motif DUF5341 PF17276.2 ETN98812.1 - 0.031 14.5 2.5 0.34 11.1 0.4 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5341) DUF726 PF05277.12 ETN98814.1 - 3.3e-10 39.4 0.0 3.6e-10 39.3 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF726) Connexin PF00029.19 ETN98814.1 - 0.08 12.7 0.1 0.093 12.5 0.1 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETN98814.1 - 0.11 11.2 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Presenilin Pes-10 PF07149.11 ETN98814.1 - 0.57 9.2 12.5 0.6 9.1 12.5 1.0 1 0 0 1 1 1 0 Pes-10 Sporozoite_P67 PF05642.11 ETN98814.1 - 0.67 8.0 3.7 0.55 8.2 3.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Tim54 PF11711.8 ETN98814.1 - 1.1 8.0 6.1 1.2 7.8 6.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SDA1 PF05285.12 ETN98814.1 - 1.6 8.1 17.7 1.7 8.0 17.7 1.0 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETN98814.1 - 5.4 5.2 15.9 5.5 5.1 15.9 1.0 1 0 0 1 1 1 0 CDC45-like protein ANAPC4_WD40 PF12894.7 ETN98815.1 - 1.5e-05 25.2 0.0 0.059 13.7 0.1 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETN98815.1 - 6e-05 22.9 0.8 1.9 8.5 0.0 3.6 3 1 0 3 3 3 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETN98815.1 - 0.00017 22.3 0.7 3.3 8.7 0.3 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat eIF2A PF08662.11 ETN98815.1 - 0.00042 20.2 0.1 0.0038 17.1 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETN98815.1 - 0.0005 19.5 0.1 0.13 11.6 0.0 2.2 1 1 1 2 2 2 2 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETN98815.1 - 0.0043 16.2 0.1 0.18 10.8 0.0 2.0 1 1 1 2 2 2 2 Coatomer WD associated region Utp8 PF10395.9 ETN98815.1 - 0.012 14.2 0.0 0.015 13.9 0.0 1.1 1 0 0 1 1 1 0 Utp8 family Proteasome_A_N PF10584.9 ETN98815.1 - 0.016 14.9 0.7 0.96 9.2 0.0 3.3 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DPPIV_N PF00930.21 ETN98815.1 - 0.074 11.8 0.0 1 8.0 0.0 2.3 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region HPIH PF13323.6 ETN98817.1 - 0.049 13.5 0.6 0.055 13.3 0.6 1.1 1 0 0 1 1 1 0 N-terminal domain with HPIH motif DUF719 PF05334.13 ETN98817.1 - 0.092 12.9 4.5 0.095 12.9 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF719) ERAP1_C PF11838.8 ETN98818.1 - 7.3e-08 32.3 0.0 7.4e-08 32.3 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Peptidase_C37 PF05416.12 ETN98819.1 - 0.032 12.8 1.8 0.045 12.3 1.8 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Folate_carrier PF01770.18 ETN98819.1 - 0.097 11.4 0.1 0.13 11.0 0.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier RPN2_C PF18004.1 ETN98819.1 - 0.94 9.4 10.8 0.032 14.1 5.0 1.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain WD40 PF00400.32 ETN98821.1 - 8.1e-08 32.8 3.7 0.012 16.4 1.1 3.2 2 1 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98821.1 - 0.00038 19.2 0.1 0.37 9.4 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98821.1 - 0.085 13.2 0.0 8.9 6.7 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain FGGY_C PF02782.16 ETN98822.1 - 0.0085 15.8 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Rimk_N PF18030.1 ETN98823.1 - 1.8e-12 47.5 0.0 3.1e-12 46.7 0.0 1.3 1 0 0 1 1 1 1 RimK PreATP-grasp domain TOM20_plant PF06552.12 ETN98823.1 - 0.15 11.8 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 EloA-BP1 PF15870.5 ETN98824.1 - 0.019 15.2 0.7 0.03 14.6 0.7 1.2 1 0 0 1 1 1 0 ElonginA binding-protein 1 PI3K_1B_p101 PF10486.9 ETN98824.1 - 0.11 10.3 5.5 0.13 10.0 5.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SR-25 PF10500.9 ETN98824.1 - 4.3 6.9 11.3 3.1 7.3 9.3 1.6 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein WD40 PF00400.32 ETN98826.1 - 5.5e-08 33.3 4.1 0.0003 21.5 0.6 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98826.1 - 0.01 14.5 0.1 0.033 12.8 0.1 1.7 1 1 0 1 1 1 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98826.1 - 0.099 13.0 0.0 18 5.7 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RIG-I_C PF18119.1 ETN98827.1 - 0.059 13.4 0.2 0.091 12.8 0.2 1.6 1 1 0 1 1 1 0 RIG-I receptor C-terminal domain HEAT PF02985.22 ETN98827.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 HEAT repeat TT_ORF1 PF02956.14 ETN98828.1 - 0.066 11.9 4.7 0.066 11.9 4.7 1.0 1 0 0 1 1 1 0 TT viral orf 1 Kelch_4 PF13418.6 ETN98829.1 - 1.4e-05 25.0 0.1 0.0053 16.7 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN98829.1 - 6.2e-05 23.1 0.6 0.0042 17.3 0.1 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETN98829.1 - 0.011 15.4 0.3 0.099 12.2 0.1 2.3 2 0 0 2 2 2 0 Kelch motif DUF5074 PF16819.5 ETN98829.1 - 0.081 13.0 0.8 0.19 11.7 0.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5074) eRF1_3 PF03465.15 ETN98830.1 - 8.6e-19 68.1 0.2 1.4e-18 67.4 0.0 1.4 2 0 0 2 2 2 1 eRF1 domain 3 DUF5074 PF16819.5 ETN98831.1 - 0.11 12.6 1.2 0.65 10.1 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5074) DUF4834 PF16118.5 ETN98832.1 - 0.12 13.3 0.1 0.12 13.3 0.1 3.5 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) Vpu PF00558.19 ETN98832.1 - 0.87 9.4 5.7 2.6 7.9 5.7 1.9 1 0 0 1 1 1 0 Vpu protein HEAT_2 PF13646.6 ETN98834.1 - 1.6e-50 169.4 44.1 1.5e-13 50.9 2.1 7.4 2 2 5 8 8 8 8 HEAT repeats HEAT PF02985.22 ETN98834.1 - 1.2e-31 106.0 13.4 0.011 15.9 0.0 12.7 12 0 0 12 12 12 8 HEAT repeat Cnd1 PF12717.7 ETN98834.1 - 3.8e-25 88.8 11.7 1.9e-08 34.5 1.4 6.8 4 2 1 5 5 5 5 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETN98834.1 - 3.4e-16 58.9 9.5 8.4e-11 41.1 0.6 3.3 2 1 1 3 3 3 3 Adaptin N terminal region Ank_4 PF13637.6 ETN98834.1 - 1.6e-11 44.5 0.1 5.2e-08 33.3 0.1 3.8 2 1 1 3 3 3 2 Ankyrin repeats (many copies) HEAT_EZ PF13513.6 ETN98834.1 - 2.2e-10 40.8 19.5 0.56 10.8 0.0 8.9 8 0 0 8 8 8 3 HEAT-like repeat DUF294 PF03445.13 ETN98834.1 - 3.6e-10 39.8 2.0 7.8e-07 29.0 0.0 4.9 6 0 0 6 6 6 1 Putative nucleotidyltransferase DUF294 Ank_2 PF12796.7 ETN98834.1 - 1.3e-09 38.5 0.1 6.4e-09 36.3 0.1 2.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF3385 PF11865.8 ETN98834.1 - 1.6e-07 31.4 4.1 0.86 9.5 0.0 6.5 4 3 0 4 4 4 2 Domain of unknown function (DUF3385) UBA_6 PF18039.1 ETN98834.1 - 9e-07 28.7 1.6 0.19 11.7 0.1 5.3 5 0 0 5 5 5 2 UBA-like domain Ank_3 PF13606.6 ETN98834.1 - 3e-06 27.2 0.1 0.0024 18.2 0.0 4.1 4 0 0 4 4 2 1 Ankyrin repeat RTP1_C1 PF10363.9 ETN98834.1 - 0.00014 22.0 3.8 7 6.9 0.0 5.2 2 1 2 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Ank_5 PF13857.6 ETN98834.1 - 0.00032 20.9 0.6 0.0014 18.9 0.1 2.5 2 0 0 2 2 1 1 Ankyrin repeats (many copies) Vac14_Fab1_bd PF12755.7 ETN98834.1 - 0.00034 21.1 0.1 5 7.8 0.0 5.9 2 2 5 7 7 7 1 Vacuolar 14 Fab1-binding region HEAT_PBS PF03130.16 ETN98834.1 - 0.00049 20.5 25.6 8.4 7.4 0.1 10.4 11 0 0 11 11 10 1 PBS lyase HEAT-like repeat DUF5071 PF16804.5 ETN98834.1 - 0.00056 20.2 1.4 1.3 9.3 0.0 5.1 5 1 0 5 5 4 1 Domain of unknown function (DUF5071) Ank PF00023.30 ETN98834.1 - 0.0084 16.5 0.0 0.063 13.8 0.0 2.7 2 0 0 2 2 1 1 Ankyrin repeat DUF4757 PF15949.5 ETN98834.1 - 4.1 7.8 10.7 1.3 9.5 5.9 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4757) Pkinase PF00069.25 ETN98835.1 - 0.08 12.3 0.5 0.1 11.9 0.5 1.1 1 0 0 1 1 1 0 Protein kinase domain Peptidase_C14 PF00656.22 ETN98836.1 - 0.0059 16.6 0.1 0.01 15.8 0.1 1.3 1 0 0 1 1 1 1 Caspase domain DUF1077 PF06417.12 ETN98836.1 - 0.0083 16.1 0.1 0.13 12.3 0.1 2.2 1 1 0 1 1 1 1 Protein of unknown function (DUF1077) Raptor_N PF14538.6 ETN98836.1 - 0.045 13.7 0.7 0.085 12.8 0.7 1.8 1 1 0 1 1 1 0 Raptor N-terminal CASPase like domain Endotoxin_M PF00555.19 ETN98836.1 - 0.21 11.6 3.7 2.4 8.2 0.8 2.2 2 0 0 2 2 2 0 delta endotoxin Kelch_1 PF01344.25 ETN98837.1 - 4.2e-06 26.3 0.1 0.043 13.4 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETN98837.1 - 8.4e-06 25.9 0.1 0.14 12.5 0.1 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETN98837.1 - 1.7e-05 24.6 0.6 0.016 15.2 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETN98837.1 - 0.0033 17.4 0.2 2.5 8.2 0.0 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETN98837.1 - 0.0072 16.6 0.0 0.37 11.1 0.0 3.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETN98837.1 - 0.0091 16.0 0.2 2.5 8.2 0.1 2.6 1 1 1 2 2 2 2 Galactose oxidase, central domain DUF4302 PF14135.6 ETN98838.1 - 0.017 15.1 1.3 0.029 14.3 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4302) Kelch_6 PF13964.6 ETN98839.1 - 0.0055 17.0 5.8 9 6.8 0.1 4.4 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETN98839.1 - 0.17 11.9 0.1 2.3 8.3 0.0 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Kinesin PF00225.23 ETN98840.1 - 2.3e-26 92.5 0.0 3e-26 92.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETN98840.1 - 2.6e-10 40.4 0.0 5.3e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Microtubule binding MdcE PF06833.11 ETN98840.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) MMR_HSR1 PF01926.23 ETN98841.1 - 2.2e-06 27.8 0.1 1.8e-05 24.8 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETN98841.1 - 0.00036 20.5 0.4 0.0018 18.2 0.4 2.1 1 1 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ETN98841.1 - 0.0011 19.5 0.0 0.002 18.7 0.0 1.5 1 0 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 ETN98841.1 - 0.0099 15.9 0.9 1.7 8.7 0.2 2.4 1 1 1 2 2 2 1 Dynamin family AAA_28 PF13521.6 ETN98841.1 - 0.014 15.7 0.0 0.026 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETN98841.1 - 0.019 14.7 0.2 0.033 13.9 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 ETN98841.1 - 0.035 13.6 0.0 0.082 12.4 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_19 PF13245.6 ETN98841.1 - 0.062 13.6 0.0 0.15 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ETN98841.1 - 0.066 12.3 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein Septin PF00735.18 ETN98841.1 - 0.078 12.2 0.0 0.16 11.2 0.0 1.5 1 0 0 1 1 1 0 Septin Zeta_toxin PF06414.12 ETN98841.1 - 0.1 11.9 0.7 0.44 9.8 0.7 2.0 1 1 0 1 1 1 0 Zeta toxin RNA_helicase PF00910.22 ETN98841.1 - 0.13 12.7 0.1 0.3 11.5 0.1 1.8 1 1 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 ETN98841.1 - 0.15 12.6 0.0 0.35 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETN98841.1 - 0.31 11.5 3.5 1.4 9.3 3.5 2.1 1 1 0 1 1 1 0 AAA domain Peptidase_C14 PF00656.22 ETN98842.1 - 7.9e-09 35.8 0.2 9.2e-09 35.6 0.2 1.1 1 0 0 1 1 1 1 Caspase domain NACHT PF05729.12 ETN98843.1 - 8.9e-12 45.2 0.0 3.1e-11 43.5 0.0 1.7 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETN98843.1 - 0.00061 19.1 0.0 0.00083 18.6 0.0 1.4 1 1 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.9 ETN98843.1 - 0.003 16.9 0.0 0.0039 16.5 0.0 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ETN98843.1 - 0.0057 16.9 0.0 0.011 16.0 0.0 1.5 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 ETN98843.1 - 0.0069 15.9 0.1 0.0081 15.6 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETN98843.1 - 0.0093 16.4 0.0 0.012 16.0 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain DAP3 PF10236.9 ETN98843.1 - 0.04 13.1 0.0 0.06 12.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATPase PF06745.13 ETN98843.1 - 0.17 11.2 0.0 1 8.7 0.0 1.9 2 0 0 2 2 2 0 KaiC FF PF01846.19 ETN98844.1 - 0.031 14.5 1.7 4.4 7.6 0.2 3.4 2 0 0 2 2 2 0 FF domain Sec20 PF03908.13 ETN98844.1 - 0.11 12.4 8.4 0.023 14.6 2.0 2.9 2 0 0 2 2 2 0 Sec20 Menin PF05053.13 ETN98847.1 - 0.00043 18.8 5.6 0.00054 18.5 5.6 1.1 1 0 0 1 1 1 1 Menin SSP160 PF06933.11 ETN98847.1 - 0.82 7.8 8.8 0.92 7.6 8.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 NST1 PF13945.6 ETN98847.1 - 1.5 8.9 10.1 2.2 8.4 10.1 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Macoilin PF09726.9 ETN98847.1 - 2.1 6.8 4.7 2.3 6.7 4.7 1.1 1 0 0 1 1 1 0 Macoilin family F-box-like PF12937.7 ETN98850.1 - 0.0021 17.9 0.1 0.006 16.5 0.1 1.7 1 0 0 1 1 1 1 F-box-like RP-C_C PF11800.8 ETN98850.1 - 0.01 16.0 0.1 0.016 15.4 0.1 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region LRR_6 PF13516.6 ETN98850.1 - 0.035 14.1 4.7 0.12 12.5 0.1 2.8 3 0 0 3 3 3 0 Leucine Rich repeat ObR_Ig PF18589.1 ETN98850.1 - 0.04 14.3 4.6 0.77 10.2 0.9 2.2 2 0 0 2 2 2 0 Obesity receptor immunoglobulin like domain DUF4645 PF15488.6 ETN98850.1 - 0.16 11.4 0.0 0.23 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4645) LRR_4 PF12799.7 ETN98850.1 - 0.31 11.5 4.6 2.1 8.9 0.9 2.5 1 1 2 3 3 3 0 Leucine Rich repeats (2 copies) RNA_pol_Rpc4 PF05132.14 ETN98850.1 - 2.4 8.6 6.6 3.1 8.2 6.6 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Sec62 PF03839.16 ETN98850.1 - 8.8 5.8 11.0 16 4.9 11.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 CDC27 PF09507.10 ETN98851.1 - 5 6.4 48.4 5.8 6.2 48.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF1010 PF06231.11 ETN98854.1 - 0.052 14.1 0.9 0.14 12.6 0.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1010) PEN-2 PF10251.9 ETN98854.1 - 1.2 9.6 4.8 0.67 10.4 1.2 2.4 2 1 0 2 2 2 0 Presenilin enhancer-2 subunit of gamma secretase SNF2_N PF00176.23 ETN98855.1 - 3.1e-67 226.8 4.2 2.1e-66 224.0 0.7 2.5 1 1 1 2 2 2 2 SNF2 family N-terminal domain FANCI_S1-cap PF14674.6 ETN98855.1 - 0.057 13.5 3.1 0.074 13.2 0.9 2.4 2 0 0 2 2 2 0 FANCI solenoid 1 cap ResIII PF04851.15 ETN98855.1 - 0.064 13.3 15.0 0.01 15.8 5.7 3.3 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit RGS12_us1 PF16613.5 ETN98855.1 - 0.15 12.4 0.1 0.15 12.4 0.1 2.6 3 0 0 3 3 3 0 Unstructured region of RGS12 GAT PF03127.14 ETN98855.1 - 1.7 9.0 6.6 3.2 8.1 0.4 3.6 4 0 0 4 4 4 0 GAT domain RTP1_C1 PF10363.9 ETN98856.1 - 0.0031 17.7 7.3 0.69 10.1 0.2 4.8 3 1 0 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Stork_head PF10264.9 ETN98856.1 - 0.0038 17.4 1.9 10 6.4 0.0 3.9 3 0 0 3 3 3 1 Winged helix Storkhead-box1 domain FPL PF09758.9 ETN98856.1 - 0.0053 16.8 29.3 1.6 8.7 0.0 7.2 4 3 3 7 7 7 3 Uncharacterised conserved protein HEAT PF02985.22 ETN98856.1 - 0.0082 16.3 0.2 4.1 7.9 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat Utp13 PF08625.11 ETN98856.1 - 0.015 15.2 23.8 3.5 7.5 0.2 6.3 2 2 3 6 6 6 0 Utp13 specific WD40 associated domain RICTOR_M PF14666.6 ETN98856.1 - 0.062 13.1 8.2 0.63 9.8 0.3 4.4 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, middle domain DUF2270 PF10028.9 ETN98856.1 - 0.11 12.1 0.1 18 4.8 0.1 2.4 2 0 0 2 2 2 0 Predicted integral membrane protein (DUF2270) P16-Arc PF04699.14 ETN98856.1 - 0.18 12.3 4.9 1.1 9.7 0.1 3.6 2 1 0 3 3 3 0 ARP2/3 complex 16 kDa subunit (p16-Arc) COP23 PF14218.6 ETN98856.1 - 0.22 11.3 3.0 1.5 8.6 2.6 2.7 1 1 1 2 2 2 0 Circadian oscillating protein COP23 COMM_domain PF07258.14 ETN98856.1 - 0.58 10.3 13.3 11 6.2 0.1 5.5 5 0 0 5 5 5 0 COMM domain DUF573 PF04504.14 ETN98856.1 - 0.62 10.8 7.9 36 5.1 0.0 4.8 5 1 0 5 5 4 0 Protein of unknown function, DUF573 Prenylcys_lyase PF07156.14 ETN98857.1 - 0.0005 19.3 0.3 0.0006 19.0 0.3 1.1 1 0 0 1 1 1 1 Prenylcysteine lyase Cupin_4 PF08007.12 ETN98858.1 - 4.1e-09 36.3 0.0 6.3e-09 35.7 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 ETN98858.1 - 3e-06 27.1 0.1 1.4e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Cupin-like domain Cupin_2 PF07883.11 ETN98858.1 - 0.0013 18.4 0.0 0.0024 17.5 0.0 1.4 1 0 0 1 1 1 1 Cupin domain PipA PF07108.11 ETN98859.1 - 0.066 12.7 0.1 0.11 12.0 0.0 1.4 1 1 0 1 1 1 0 PipA protein SDP_N PF12278.8 ETN98859.1 - 1.4 9.0 9.3 3.7 7.7 3.2 2.6 2 1 0 2 2 2 0 Sex determination protein N terminal zf-C2H2 PF00096.26 ETN98860.1 - 1.4e-05 25.3 3.4 0.00085 19.6 0.1 6.5 7 0 0 7 7 7 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETN98860.1 - 4.2e-05 24.0 36.9 0.05 14.5 0.5 6.5 7 0 0 7 7 6 3 C2H2-type zinc finger zf-Di19 PF05605.12 ETN98860.1 - 8.8e-05 22.7 3.6 8.8e-05 22.7 3.6 4.1 3 1 0 4 4 4 1 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 ETN98860.1 - 0.0028 18.0 0.9 0.0028 18.0 0.9 5.8 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ETN98860.1 - 0.0038 17.5 2.4 0.0038 17.5 2.4 4.8 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETN98860.1 - 0.01 16.2 0.8 0.01 16.2 0.8 3.9 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-MYST PF17772.1 ETN98860.1 - 0.03 13.9 1.3 0.03 13.9 1.3 4.5 4 1 1 5 5 5 0 MYST family zinc finger domain HET PF06985.11 ETN98860.1 - 0.048 14.0 1.5 0.059 13.7 1.5 1.3 1 1 0 1 1 1 0 Heterokaryon incompatibility protein (HET) zf_Hakai PF18408.1 ETN98860.1 - 0.13 12.0 0.1 0.13 12.0 0.1 4.2 4 1 0 4 4 3 0 C2H2 Hakai zinc finger domain Plasmid_parti PF01672.16 ETN98860.1 - 0.14 12.9 3.4 5.6 7.7 0.2 2.6 2 1 0 2 2 2 0 Putative plasmid partition protein C1_4 PF07975.12 ETN98860.1 - 9.5 6.5 19.8 0.74 10.1 0.5 4.2 3 1 1 4 4 4 0 TFIIH C1-like domain zf-HIT PF04438.16 ETN98860.1 - 10 6.1 19.2 2.4 8.1 0.5 4.5 4 0 0 4 4 4 0 HIT zinc finger TPR_12 PF13424.6 ETN98861.1 - 1.5e-10 41.2 0.1 3.3e-10 40.1 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98861.1 - 2.9e-08 33.3 0.1 1.5e-06 27.9 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98861.1 - 3.2e-06 26.7 3.4 1.9e-05 24.3 0.2 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98861.1 - 3.8e-06 26.7 4.1 5.1e-06 26.3 0.4 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98861.1 - 2.3e-05 24.2 2.5 0.00039 20.3 0.2 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98861.1 - 0.00032 20.5 0.0 0.0017 18.3 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETN98861.1 - 0.031 14.1 0.1 0.059 13.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) DUF2225 PF09986.9 ETN98861.1 - 0.075 12.8 0.3 0.096 12.4 0.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) MethyltransfD12 PF02086.15 ETN98864.1 - 4.3e-16 59.4 1.0 5.1e-16 59.1 0.1 1.5 2 0 0 2 2 2 1 D12 class N6 adenine-specific DNA methyltransferase HSDR_N_2 PF13588.6 ETN98864.1 - 0.0022 18.0 1.3 0.047 13.7 0.2 2.5 2 1 1 3 3 3 2 Type I restriction enzyme R protein N terminus (HSDR_N) DUF2457 PF10446.9 ETN98865.1 - 0.58 9.2 18.2 0.63 9.1 18.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CCDC53 PF10152.9 ETN98866.1 - 0.01 16.2 14.4 0.031 14.7 14.4 1.8 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF4603 PF15376.6 ETN98868.1 - 3.2 5.0 11.6 3.5 4.9 11.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Kelch_1 PF01344.25 ETN98869.1 - 2.4e-08 33.4 3.0 9.4e-05 21.9 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETN98869.1 - 1.9e-05 24.8 1.9 0.19 12.1 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Radial_spoke PF04712.12 ETN98869.1 - 0.00012 21.2 4.4 0.00019 20.6 4.4 1.3 1 0 0 1 1 1 1 Radial spokehead-like protein Kelch_2 PF07646.15 ETN98869.1 - 0.00014 21.7 1.1 0.041 13.9 0.4 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETN98869.1 - 0.00017 21.5 0.7 0.0025 17.8 0.1 2.8 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETN98869.1 - 0.00061 20.0 0.1 0.013 15.8 0.0 2.8 3 0 0 3 3 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN98869.1 - 0.025 14.5 0.5 0.65 10.0 0.2 2.9 3 0 0 3 3 3 0 Kelch motif Pet20 PF08692.10 ETN98869.1 - 0.074 13.8 5.0 0.35 11.6 0.0 2.4 2 0 0 2 2 2 0 Mitochondrial protein Pet20 FAM176 PF14851.6 ETN98869.1 - 0.47 10.1 5.2 1.3 8.7 5.2 1.7 1 0 0 1 1 1 0 FAM176 family E7 PF00527.18 ETN98869.1 - 0.88 9.8 6.3 2.8 8.2 6.3 1.8 1 0 0 1 1 1 0 E7 protein, Early protein DUF3682 PF12446.8 ETN98869.1 - 8.6 6.8 8.7 16 6.0 8.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) DUF16 PF01519.16 ETN98870.1 - 0.0075 16.7 34.8 0.19 12.3 13.7 3.1 1 1 2 3 3 3 2 Protein of unknown function DUF16 DUF641 PF04859.12 ETN98870.1 - 0.042 14.2 3.0 0.042 14.2 3.0 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) TPR_MLP1_2 PF07926.12 ETN98870.1 - 0.4 10.8 25.5 0.036 14.1 10.7 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Bacillus_HBL PF05791.11 ETN98870.1 - 1.3 8.8 29.9 1.7 8.4 10.5 2.9 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) UPF0242 PF06785.11 ETN98870.1 - 1.6 8.8 32.7 0.98 9.5 11.1 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 ETN98870.1 - 2.4 8.2 19.5 5.9 6.9 6.3 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Glycohydro_20b2 PF14845.6 ETN98870.1 - 5.7 7.6 10.8 11 6.7 10.8 1.7 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like YtxH PF12732.7 ETN98870.1 - 7.2 7.2 9.3 2.4e+03 -0.9 9.3 3.1 1 1 0 1 1 1 0 YtxH-like protein Jnk-SapK_ap_N PF09744.9 ETN98870.1 - 8.6 6.6 27.2 1.6 8.9 16.8 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.10 ETN98870.1 - 9.1 6.5 27.9 1.9 8.7 1.5 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family MvaI_BcnI PF15515.6 ETN98872.1 - 5e-36 124.7 3.0 9.1e-36 123.8 0.0 2.5 2 1 0 2 2 2 1 MvaI/BcnI restriction endonuclease family Dynactin_p22 PF07426.11 ETN98872.1 - 0.05 13.5 8.7 0.11 12.3 8.7 1.6 1 0 0 1 1 1 0 Dynactin subunit p22 EF-G-binding_N PF07299.11 ETN98872.1 - 0.12 12.9 1.5 0.58 10.7 1.5 2.2 1 1 0 1 1 1 0 Elongation factor G-binding protein, N-terminal DUF1912 PF08930.10 ETN98872.1 - 0.65 10.2 4.5 5.9 7.1 0.8 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1912) CarD_CdnL_TRCF PF02559.16 ETN98872.1 - 0.93 10.2 4.3 12 6.7 0.1 2.6 2 0 0 2 2 2 0 CarD-like/TRCF domain DUF4172 PF13776.6 ETN98873.1 - 0.032 14.6 3.2 6.1 7.2 0.2 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4172) FAM176 PF14851.6 ETN98875.1 - 0.17 11.6 4.8 0.2 11.3 4.8 1.1 1 0 0 1 1 1 0 FAM176 family Paf1 PF03985.13 ETN98875.1 - 1.1 8.2 9.9 1.2 8.1 9.9 1.0 1 0 0 1 1 1 0 Paf1 CENP-B_dimeris PF09026.10 ETN98875.1 - 1.4 9.3 8.1 1.8 9.0 8.1 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Radial_spoke PF04712.12 ETN98875.1 - 1.6 7.6 11.4 1.7 7.5 11.4 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein DUF4746 PF15928.5 ETN98875.1 - 2.2 7.6 7.9 2.4 7.5 7.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 ETN98875.1 - 2.4 6.4 6.6 2.5 6.3 6.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 ETN98875.1 - 2.7 7.7 6.1 3 7.6 6.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein U-box PF04564.15 ETN98876.1 - 6.6e-07 29.4 0.1 1.1e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 U-box domain TPM_phosphatase PF04536.14 ETN98877.1 - 1.8e-15 57.2 0.0 2.5e-15 56.8 0.0 1.2 1 0 0 1 1 1 1 TPM domain MOLO1 PF17175.4 ETN98877.1 - 4.3e-05 23.6 0.1 9.1e-05 22.6 0.0 1.6 2 0 0 2 2 2 1 Modulator of levamisole receptor-1 OATP PF03137.20 ETN98878.1 - 2.9e-07 29.2 14.0 0.00024 19.5 1.7 3.1 2 1 0 2 2 2 2 Organic Anion Transporter Polypeptide (OATP) family Gram_pos_anchor PF00746.21 ETN98878.1 - 0.17 11.9 1.7 0.44 10.5 1.7 1.7 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DUF2353 PF09789.9 ETN98879.1 - 0.00097 18.6 8.9 0.0013 18.1 8.9 1.2 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Wzy_C PF04932.15 ETN98879.1 - 0.0065 16.1 0.1 0.0071 16.0 0.1 1.2 1 0 0 1 1 1 1 O-Antigen ligase OAD_gamma PF04277.13 ETN98879.1 - 0.0071 16.9 0.5 0.0071 16.9 0.5 1.7 2 0 0 2 2 1 1 Oxaloacetate decarboxylase, gamma chain OATP PF03137.20 ETN98879.1 - 0.0094 14.3 0.4 0.01 14.1 0.4 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family DUF3452 PF11934.8 ETN98879.1 - 0.012 15.2 1.6 0.014 14.9 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) DUF5385 PF17359.2 ETN98879.1 - 0.014 15.0 8.1 0.023 14.2 8.1 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5385) DivIC PF04977.15 ETN98879.1 - 0.021 14.6 5.8 0.076 12.8 0.3 2.4 2 0 0 2 2 2 0 Septum formation initiator Adeno_E3_CR2 PF02439.15 ETN98879.1 - 0.024 14.4 0.5 0.024 14.4 0.5 1.8 2 0 0 2 2 1 0 Adenovirus E3 region protein CR2 Peptidase_S30 PF01577.16 ETN98879.1 - 0.028 14.0 4.0 0.037 13.6 4.0 1.0 1 0 0 1 1 1 0 Potyvirus P1 protease Rib_hydrolayse PF02267.17 ETN98879.1 - 0.057 12.8 0.4 0.07 12.5 0.4 1.1 1 0 0 1 1 1 0 ADP-ribosyl cyclase MMM1 PF10296.9 ETN98879.1 - 0.084 11.9 3.9 0.11 11.5 3.9 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF2140 PF09911.9 ETN98879.1 - 0.11 12.0 4.5 0.16 11.5 4.0 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) UDPGT PF00201.18 ETN98879.1 - 0.25 10.1 2.2 0.3 9.8 2.2 1.1 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase OmpH PF03938.14 ETN98879.1 - 0.28 11.5 9.1 0.36 11.2 9.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Com_YlbF PF06133.11 ETN98879.1 - 0.28 11.8 10.0 0.29 11.8 9.1 1.4 1 1 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA ZapB PF06005.12 ETN98879.1 - 1.9 9.0 12.4 4.8 7.7 2.3 2.2 2 0 0 2 2 2 0 Cell division protein ZapB TMF_TATA_bd PF12325.8 ETN98879.1 - 2 8.7 13.9 0.2 11.9 3.3 2.0 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding M PF02370.16 ETN98879.1 - 2.2 9.1 20.2 0.93 10.3 13.5 2.7 2 0 0 2 2 2 0 M protein repeat DUF2681 PF10883.8 ETN98879.1 - 2.7 8.5 11.1 0.35 11.3 4.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Med21 PF11221.8 ETN98879.1 - 9.3 6.5 12.7 1.1 9.5 1.8 2.0 1 1 1 2 2 2 0 Subunit 21 of Mediator complex Chorein_N PF12624.7 ETN98881.1 - 1.7e-13 50.7 3.5 3.4e-07 30.4 0.8 2.4 1 1 1 2 2 2 2 N-terminal region of Chorein or VPS13 RcpB PF16971.5 ETN98881.1 - 0.039 13.9 0.3 0.065 13.1 0.3 1.3 1 0 0 1 1 1 0 Rough colony protein B, tight adherence - tad - subunit tRNA-synt_1c_C PF03950.18 ETN98883.1 - 3.2e-33 115.0 0.3 7.6e-33 113.8 0.3 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain Topo-VIb_trans PF09239.11 ETN98885.1 - 0.08 12.8 1.3 0.21 11.4 0.0 2.0 2 0 0 2 2 2 0 Topoisomerase VI B subunit, transducer CCDC-167 PF15188.6 ETN98885.1 - 0.15 12.4 6.7 0.2 12.0 5.8 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 ABC_tran_CTD PF16326.5 ETN98885.1 - 0.22 11.8 7.8 0.3 11.4 6.7 1.8 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF5344 PF17279.2 ETN98885.1 - 0.23 12.0 5.4 0.82 10.3 5.4 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5344) RRP36 PF06102.12 ETN98885.1 - 0.57 10.1 9.7 0.7 9.8 9.7 1.2 1 1 0 1 1 1 0 rRNA biogenesis protein RRP36 Vpu PF00558.19 ETN98885.1 - 4 7.3 6.8 1.4 8.7 3.1 2.0 1 1 1 2 2 2 0 Vpu protein SPARC_Ca_bdg PF10591.9 ETN98887.1 - 0.0051 17.1 0.9 0.011 16.0 0.8 1.7 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region CUE PF02845.16 ETN98888.1 - 0.0054 16.4 0.2 0.008 15.9 0.2 1.3 1 0 0 1 1 1 1 CUE domain Peptidase_C14 PF00656.22 ETN98889.1 - 4.4e-09 36.7 2.7 9e-09 35.6 2.7 1.5 1 0 0 1 1 1 1 Caspase domain Kelch_1 PF01344.25 ETN98889.1 - 0.0011 18.5 2.5 0.0015 18.0 0.6 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETN98889.1 - 0.051 13.6 3.5 0.069 13.1 0.3 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETN98889.1 - 0.7 9.9 3.2 9.9 6.3 0.5 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETN98889.1 - 0.79 10.1 3.1 12 6.3 0.2 3.0 2 1 0 2 2 2 0 Kelch motif DUF1892 PF08987.10 ETN98892.1 - 0.04 14.1 7.2 0.047 13.9 5.7 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1892) DUF719 PF05334.13 ETN98893.1 - 0.0042 17.3 6.2 0.0057 16.9 6.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF719) DUF3357 PF11837.8 ETN98893.1 - 0.01 16.3 0.9 0.016 15.7 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) DcuC PF03606.15 ETN98893.1 - 0.072 11.5 2.5 0.091 11.2 2.5 1.1 1 0 0 1 1 1 0 C4-dicarboxylate anaerobic carrier SID-1_RNA_chan PF13965.6 ETN98893.1 - 0.096 11.1 3.9 0.12 10.8 3.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Myc_N PF01056.18 ETN98893.1 - 0.13 12.1 5.5 0.16 11.9 5.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Peptidase_S49_N PF08496.10 ETN98893.1 - 0.71 9.9 4.1 1.1 9.3 4.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Apis_Csd PF11671.8 ETN98895.1 - 0.018 15.1 0.3 0.023 14.7 0.3 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein WD40 PF00400.32 ETN98896.1 - 0.0006 20.6 2.1 0.27 12.2 0.4 3.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ADH_N_2 PF16884.5 ETN98896.1 - 0.028 14.3 0.0 0.078 12.9 0.0 1.7 2 0 0 2 2 2 0 N-terminal domain of oxidoreductase FN3_7 PF18447.1 ETN98896.1 - 0.91 9.9 7.9 0.68 10.3 5.7 2.0 2 1 0 2 2 2 0 Fibronectin type III domain fn3 PF00041.21 ETN98897.1 - 4.6e-12 46.1 2.7 1e-06 29.0 0.7 3.3 2 1 0 2 2 2 2 Fibronectin type III domain DUF2369 PF10179.9 ETN98897.1 - 0.00057 20.2 0.1 0.0069 16.7 0.1 2.5 2 0 0 2 2 2 1 Uncharacterised conserved protein (DUF2369) zf-TRAF PF02176.18 ETN98898.1 - 3.7e-06 27.5 3.2 3.7e-06 27.5 3.2 3.3 2 1 2 4 4 4 1 TRAF-type zinc finger Sina PF03145.16 ETN98898.1 - 0.014 15.3 5.8 0.014 15.3 5.8 2.0 1 1 2 3 3 3 0 Seven in absentia protein family zf-TRAF_2 PF15965.5 ETN98898.1 - 3.7 8.1 12.3 0.34 11.4 1.3 3.2 1 1 2 3 3 3 0 TRAF-like zinc-finger ABC_membrane PF00664.23 ETN98900.1 - 2.5e-28 99.5 0.1 2.6e-28 99.4 0.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ETN98901.1 - 8.5e-13 49.0 0.0 1.9e-12 47.9 0.0 1.6 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ETN98901.1 - 0.00012 22.1 0.0 0.00035 20.5 0.0 1.7 1 1 1 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ETN98901.1 - 0.00019 21.1 0.2 0.00034 20.3 0.2 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ETN98901.1 - 0.00029 21.3 0.0 0.00041 20.8 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ETN98901.1 - 0.0036 17.8 0.4 0.0057 17.2 0.2 1.4 1 1 0 1 1 1 1 AAA domain ABC_membrane PF00664.23 ETN98901.1 - 0.004 16.8 0.4 0.0058 16.3 0.4 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF87 PF01935.17 ETN98901.1 - 0.018 15.1 0.2 0.036 14.2 0.1 1.5 1 1 0 1 1 1 0 Helicase HerA, central domain G-alpha PF00503.20 ETN98901.1 - 0.019 14.1 0.0 0.026 13.7 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_22 PF13401.6 ETN98901.1 - 0.024 14.9 0.0 0.049 13.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETN98901.1 - 0.029 13.9 0.0 0.056 13.0 0.0 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_21 PF13304.6 ETN98901.1 - 0.048 13.5 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Rad17 PF03215.15 ETN98901.1 - 0.067 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_18 PF13238.6 ETN98901.1 - 0.068 13.7 0.0 0.11 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ETN98901.1 - 0.073 12.8 0.2 0.073 12.8 0.2 1.4 2 0 0 2 2 2 0 AAA ATPase domain AAA_30 PF13604.6 ETN98901.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETN98901.1 - 0.08 12.7 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATP-synt_ab PF00006.25 ETN98901.1 - 0.098 12.3 0.0 0.26 10.9 0.0 1.6 2 0 0 2 2 2 0 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 ETN98901.1 - 0.13 11.4 0.0 0.24 10.5 0.0 1.4 1 1 0 1 1 1 0 NB-ARC domain SMC_N PF02463.19 ETN98901.1 - 0.15 11.5 0.5 0.28 10.6 0.3 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_28 PF13521.6 ETN98901.1 - 0.15 12.3 0.0 0.22 11.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETN98901.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Cytidylate_kin PF02224.18 ETN98901.1 - 0.16 11.7 0.0 0.26 11.0 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase AAA_33 PF13671.6 ETN98901.1 - 0.21 11.8 0.0 0.38 10.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 ETN98902.1 - 5.6e-06 27.0 1.2 2.3e-05 25.1 0.3 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat Pneumo_M2 PF07380.11 ETN98902.1 - 1.2 9.4 7.2 0.43 10.9 2.9 2.1 2 0 0 2 2 2 0 Pneumovirus M2 protein DIX PF00778.17 ETN98902.1 - 3.6 7.5 8.7 0.16 11.9 1.6 2.2 1 1 1 2 2 2 0 DIX domain EDS1_EP PF18117.1 ETN98903.1 - 0.022 15.2 3.5 0.093 13.2 0.2 3.3 3 0 0 3 3 3 0 Enhanced disease susceptibility 1 protein EP domain DUF72 PF01904.18 ETN98904.1 - 0.1 12.7 0.1 1.1 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function DUF72 Ank_2 PF12796.7 ETN98906.1 - 1.7e-24 86.2 16.2 1.2e-09 38.7 1.0 4.1 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETN98906.1 - 2e-16 58.4 2.3 0.024 15.1 0.0 5.7 5 0 0 5 5 5 5 Ankyrin repeat Ank_4 PF13637.6 ETN98906.1 - 2.9e-14 53.2 1.5 1.9e-05 25.1 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ETN98906.1 - 9.6e-11 41.6 2.0 0.023 15.2 0.0 5.6 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ETN98906.1 - 5.5e-10 39.3 0.4 0.0056 17.0 0.0 4.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) C1_2 PF03107.16 ETN98906.1 - 0.024 14.9 0.8 0.024 14.9 0.8 3.7 3 1 0 3 3 3 0 C1 domain DUF3447 PF11929.8 ETN98906.1 - 0.045 13.7 0.5 5 7.2 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3447) Pribosyltran PF00156.27 ETN98906.1 - 0.1 12.1 0.0 3.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Phosphoribosyl transferase domain NCD3G PF07562.14 ETN98906.1 - 0.37 10.8 0.1 0.37 10.8 0.1 4.2 4 1 0 5 5 5 0 Nine Cysteines Domain of family 3 GPCR SAPS PF04499.15 ETN98906.1 - 9.8 4.8 7.4 16 4.1 7.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Tmemb_18A PF09771.9 ETN98907.1 - 0.0051 17.2 1.3 0.006 17.0 0.7 1.5 1 1 0 1 1 1 1 Transmembrane protein 188 Glycos_transf_1 PF00534.20 ETN98908.1 - 2.5e-15 56.5 0.0 4.1e-15 55.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETN98908.1 - 8.6e-10 39.2 0.0 1.5e-09 38.4 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ETN98908.1 - 0.0015 18.9 0.0 0.0074 16.7 0.0 2.1 2 1 0 2 2 2 1 Glycosyl transferases group 1 Glycogen_syn PF05693.13 ETN98908.1 - 0.015 13.9 0.0 0.019 13.5 0.0 1.2 1 0 0 1 1 1 0 Glycogen synthase Halogen_Hydrol PF10112.9 ETN98908.1 - 0.025 14.6 0.5 0.04 13.9 0.5 1.3 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF713 PF05218.14 ETN98913.1 - 0.015 15.0 1.0 0.021 14.5 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF713) Copine PF07002.16 ETN98914.1 - 5e-09 35.9 0.1 6.1e-09 35.6 0.1 1.1 1 0 0 1 1 1 1 Copine OTCace PF00185.24 ETN98916.1 - 1.1e-10 41.8 2.0 4.1e-10 39.9 0.4 2.3 2 1 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain baeRF_family3 PF18845.1 ETN98916.1 - 0.052 13.8 0.1 0.1 12.9 0.0 1.5 1 1 1 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 Chorismate_synt PF01264.21 ETN98917.1 - 0.054 12.2 0.1 0.069 11.9 0.1 1.1 1 0 0 1 1 1 0 Chorismate synthase DUF4838 PF16126.5 ETN98918.1 - 0.04 13.3 0.1 0.053 12.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) DUF4834 PF16118.5 ETN98920.1 - 0.0029 18.5 0.6 0.0035 18.3 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Tmemb_9 PF05434.11 ETN98920.1 - 0.078 12.9 0.9 0.083 12.8 0.9 1.2 1 0 0 1 1 1 0 TMEM9 Baculo_11_kDa PF06143.11 ETN98920.1 - 0.083 12.5 4.4 0.12 12.0 4.4 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF929 PF06053.11 ETN98920.1 - 0.093 12.0 7.5 0.11 11.8 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Shisa PF13908.6 ETN98920.1 - 0.14 12.4 10.2 0.15 12.3 10.2 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator tRNA_anti-like PF12869.7 ETN98920.1 - 0.16 11.5 6.9 0.17 11.5 6.9 1.2 1 0 0 1 1 1 0 tRNA_anti-like OAD_gamma PF04277.13 ETN98920.1 - 0.38 11.4 19.5 0.52 10.9 19.5 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF2895 PF11444.8 ETN98920.1 - 0.5 9.7 1.6 0.53 9.6 1.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2895) CBP_BcsG PF11658.8 ETN98920.1 - 0.83 8.0 5.8 0.82 8.0 5.8 1.0 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG SKN1 PF03935.15 ETN98920.1 - 0.94 7.8 2.4 0.92 7.8 2.4 1.0 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) ODV-E18 PF10717.9 ETN98920.1 - 1.3 9.0 17.5 1.8 8.5 16.3 1.8 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 DUF2207 PF09972.9 ETN98920.1 - 3.2 6.4 5.9 3.1 6.5 5.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5385 PF17359.2 ETN98920.1 - 5.3 6.5 5.1 6.3 6.3 5.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Hid1 PF12722.7 ETN98921.1 - 0.89 7.6 11.1 0.99 7.4 11.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MFMR_assoc PF16596.5 ETN98921.1 - 0.99 9.9 10.8 1.2 9.6 10.0 1.6 1 1 0 1 1 1 0 Disordered region downstream of MFMR TPR_MLP1_2 PF07926.12 ETN98924.1 - 7.7e-05 22.8 34.6 0.0014 18.7 12.8 3.0 1 1 2 3 3 3 3 TPR/MLP1/MLP2-like protein GAS PF13851.6 ETN98924.1 - 0.00033 20.1 28.9 0.0095 15.3 15.8 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding HrpB7 PF09486.10 ETN98924.1 - 0.00098 19.5 12.3 0.0016 18.8 12.3 1.3 1 1 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) IFT57 PF10498.9 ETN98924.1 - 0.0028 16.7 26.9 0.004 16.2 22.7 1.9 1 1 1 2 2 2 1 Intra-flagellar transport protein 57 Jnk-SapK_ap_N PF09744.9 ETN98924.1 - 0.0032 17.7 18.8 0.0032 17.7 18.8 2.2 1 1 1 2 2 2 1 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.9 ETN98924.1 - 0.0094 16.0 22.7 0.0094 16.0 22.7 1.8 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 JIP_LZII PF16471.5 ETN98924.1 - 0.011 15.9 16.7 0.049 13.8 1.8 3.3 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II APG6_N PF17675.1 ETN98924.1 - 0.014 15.9 22.3 0.014 15.9 22.3 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region CALCOCO1 PF07888.11 ETN98924.1 - 0.015 14.2 23.2 0.035 13.0 23.2 1.5 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HIP1_clath_bdg PF16515.5 ETN98924.1 - 0.016 15.8 30.3 0.038 14.6 9.8 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Macoilin PF09726.9 ETN98924.1 - 0.026 13.1 20.2 0.031 12.8 20.2 1.1 1 0 0 1 1 1 0 Macoilin family Fez1 PF06818.15 ETN98924.1 - 0.039 14.4 23.2 0.053 14.0 23.2 1.1 1 0 0 1 1 1 0 Fez1 OmpH PF03938.14 ETN98924.1 - 0.063 13.6 24.5 0.91 9.9 24.4 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DASH_Duo1 PF08651.10 ETN98924.1 - 0.071 12.9 13.0 0.2 11.4 9.6 2.5 1 1 1 2 2 2 0 DASH complex subunit Duo1 KASH_CCD PF14662.6 ETN98924.1 - 0.072 12.9 26.2 1.3 8.9 25.9 2.1 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF4201 PF13870.6 ETN98924.1 - 0.13 12.0 25.7 0.31 10.8 5.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Phage_GP20 PF06810.11 ETN98924.1 - 0.18 11.6 23.9 1 9.1 7.5 3.0 1 1 2 3 3 3 0 Phage minor structural protein GP20 Exonuc_VII_L PF02601.15 ETN98924.1 - 0.19 11.2 18.4 0.25 10.9 18.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4200 PF13863.6 ETN98924.1 - 0.2 12.1 26.6 0.43 11.0 10.5 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) Spc7 PF08317.11 ETN98924.1 - 0.25 10.2 26.7 0.068 12.0 15.7 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Rab5-bind PF09311.11 ETN98924.1 - 0.25 10.7 26.0 0.91 8.8 25.9 2.1 1 1 0 1 1 1 0 Rabaptin-like protein CENP-H PF05837.12 ETN98924.1 - 0.26 11.7 24.2 0.15 12.5 15.9 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF3584 PF12128.8 ETN98924.1 - 0.27 8.7 23.7 0.54 7.7 23.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Lipoprotein_6 PF01441.19 ETN98924.1 - 0.29 11.1 9.4 1 9.4 3.7 2.4 1 1 1 2 2 2 0 Lipoprotein DUF3450 PF11932.8 ETN98924.1 - 0.33 10.2 27.3 0.83 8.9 4.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ERM PF00769.19 ETN98924.1 - 0.34 10.7 26.8 0.41 10.4 26.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Mod_r PF07200.13 ETN98924.1 - 0.35 11.0 29.6 0.44 10.6 19.4 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Atg14 PF10186.9 ETN98924.1 - 0.35 9.9 19.8 0.43 9.6 19.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MbeD_MobD PF04899.12 ETN98924.1 - 0.4 10.8 22.7 0.13 12.4 2.2 3.5 1 1 2 3 3 3 0 MbeD/MobD like HemX PF04375.14 ETN98924.1 - 0.45 9.8 27.8 14 4.9 27.8 2.0 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase MCC-bdg_PDZ PF10506.9 ETN98924.1 - 0.47 10.5 14.3 0.29 11.2 1.9 2.6 2 1 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome V_ATPase_I PF01496.19 ETN98924.1 - 0.61 7.9 16.9 0.76 7.6 16.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 ETN98924.1 - 0.65 10.0 17.1 2.7 8.0 10.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SIKE PF05769.11 ETN98924.1 - 0.88 9.5 24.3 0.16 11.9 14.2 2.3 1 1 1 2 2 2 0 SIKE family zf-CpG_bind_C PF12269.8 ETN98924.1 - 0.95 9.2 19.9 0.17 11.6 7.6 2.0 1 1 1 2 2 2 0 CpG binding protein zinc finger C terminal domain FAP206 PF12018.8 ETN98924.1 - 0.96 8.9 19.4 1.3 8.5 7.1 2.0 1 1 1 2 2 2 0 Domain of unknown function Glutaminase PF04960.15 ETN98924.1 - 0.99 8.5 6.3 1.4 8.0 6.3 1.2 1 0 0 1 1 1 0 Glutaminase Nup88 PF10168.9 ETN98924.1 - 1.3 6.8 17.7 1.4 6.6 17.7 1.0 1 0 0 1 1 1 0 Nuclear pore component Mt_ATP-synt_D PF05873.12 ETN98924.1 - 1.3 8.9 15.5 1.6 8.6 2.8 2.1 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF16 PF01519.16 ETN98924.1 - 1.4 9.5 19.4 0.35 11.4 4.8 2.2 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF3683 PF12447.8 ETN98924.1 - 1.4 9.0 8.7 1.3 9.2 2.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3683) Rootletin PF15035.6 ETN98924.1 - 1.5 8.8 28.9 0.62 10.1 11.7 3.0 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion LMBR1 PF04791.16 ETN98924.1 - 1.6 7.6 16.9 1.8 7.4 16.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DivIC PF04977.15 ETN98924.1 - 1.7 8.5 25.4 0.43 10.4 2.9 3.5 1 1 2 3 3 3 0 Septum formation initiator DUF1043 PF06295.12 ETN98924.1 - 1.7 8.7 29.0 1.4 9.0 12.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF5595 PF18077.1 ETN98924.1 - 1.7 8.8 19.8 1.4 9.1 2.7 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF5595) COLFI PF01410.18 ETN98924.1 - 1.9 7.7 12.9 2.4 7.4 12.9 1.0 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain FUSC PF04632.12 ETN98924.1 - 3.1 6.2 6.3 3.7 6.0 6.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DivIVA PF05103.13 ETN98924.1 - 3.1 7.9 22.4 3.1 7.9 12.9 2.3 1 1 1 2 2 2 0 DivIVA protein FapA PF03961.13 ETN98924.1 - 3.9 6.0 20.9 5.1 5.6 16.1 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A YabA PF06156.13 ETN98924.1 - 4.1 8.1 22.6 3.1 8.5 12.0 2.5 1 1 2 3 3 3 0 Initiation control protein YabA Golgin_A5 PF09787.9 ETN98924.1 - 4.7 6.6 30.6 9.3 5.6 30.6 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 KELK PF15796.5 ETN98924.1 - 4.9 7.7 24.4 4.4 7.8 14.7 2.7 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ZapB PF06005.12 ETN98924.1 - 5.2 7.6 33.0 4.4 7.8 10.1 3.4 1 1 1 3 3 3 0 Cell division protein ZapB FAA_hydro_N_2 PF18288.1 ETN98924.1 - 5.4 7.5 13.3 6.6 7.2 1.9 3.2 1 1 1 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 HAUS-augmin3 PF14932.6 ETN98924.1 - 6 6.4 27.9 0.86 9.1 12.2 2.1 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 Uso1_p115_C PF04871.13 ETN98924.1 - 7 7.0 28.6 15 6.0 16.8 2.6 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region LPP PF04728.13 ETN98924.1 - 7.4 7.0 16.0 1.5e+03 -0.4 15.9 3.6 1 1 0 1 1 1 0 Lipoprotein leucine-zipper Neur_chan_memb PF02932.16 ETN98924.1 - 7.5 6.5 10.1 9.9 6.1 10.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region UPF0242 PF06785.11 ETN98924.1 - 8 6.5 31.5 1.2e+03 -0.6 31.5 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4446 PF14584.6 ETN98924.1 - 8.2 6.4 17.3 2.4 8.1 2.4 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF4446) Prefoldin PF02996.17 ETN98924.1 - 8.2 6.4 22.3 7.5 6.5 1.8 3.5 1 1 2 3 3 3 0 Prefoldin subunit Fmp27_WPPW PF10359.9 ETN98924.1 - 8.7 5.1 23.1 29 3.3 23.1 1.7 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain TSNAXIP1_N PF15739.5 ETN98924.1 - 8.8 6.8 23.2 2.3 8.6 10.5 3.3 1 1 3 4 4 3 0 Translin-associated factor X-interacting N-terminus DUF4407 PF14362.6 ETN98924.1 - 9.2 5.5 18.5 36 3.6 18.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 ETN98924.1 - 9.6 4.9 17.7 12 4.5 17.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Prominin PF05478.11 ETN98924.1 - 9.6 4.0 18.4 15 3.3 18.4 1.4 1 1 0 1 1 1 0 Prominin Pkinase PF00069.25 ETN98926.1 - 5.3e-45 153.8 0.1 8.3e-45 153.2 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN98926.1 - 1.8e-29 102.8 0.1 2.3e-29 102.5 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETN98926.1 - 0.00013 21.4 0.0 0.00027 20.4 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 ETN98926.1 - 0.0039 16.3 0.1 0.0071 15.4 0.1 1.5 1 0 0 1 1 1 1 Seadornavirus VP7 Choline_kinase PF01633.20 ETN98926.1 - 0.043 13.4 0.4 0.043 13.4 0.4 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase VPS13_mid_rpt PF16910.5 ETN98926.1 - 0.084 12.3 1.5 0.14 11.6 1.5 1.3 1 0 0 1 1 1 0 Repeating coiled region of VPS13 SPOUT_MTase PF02590.17 ETN98926.1 - 8 6.4 7.2 0.45 10.5 0.3 2.0 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase Glu-tRNAGln PF02686.15 ETN98927.1 - 0.024 14.9 1.0 0.93 9.8 0.0 3.6 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit PKK PF12474.8 ETN98927.1 - 0.091 12.9 0.0 0.091 12.9 0.0 3.9 4 1 0 4 4 4 0 Polo kinase kinase TetR_C_13 PF16925.5 ETN98927.1 - 0.81 9.6 2.9 23 5.0 0.1 4.1 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Proteasome PF00227.26 ETN98928.1 - 9.1e-29 100.3 0.0 1.2e-28 99.9 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit HSP90 PF00183.18 ETN98929.1 - 3.2e-35 122.0 11.2 1.2e-17 64.1 2.9 2.1 1 1 1 2 2 2 2 Hsp90 protein DUF2012 PF09430.10 ETN98929.1 - 0.011 15.8 0.9 0.011 15.8 0.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2012) Gemini_AL1 PF00799.20 ETN98929.1 - 0.053 13.9 1.5 0.71 10.3 0.1 2.7 2 0 0 2 2 2 0 Geminivirus Rep catalytic domain Mem_trans PF03547.18 ETN98930.1 - 0.66 8.3 6.8 0.82 8.0 6.8 1.0 1 0 0 1 1 1 0 Membrane transport protein CobT PF06213.12 ETN98931.1 - 0.0094 15.4 16.1 0.0097 15.3 16.1 1.0 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 ETN98931.1 - 0.029 12.6 19.6 0.028 12.7 19.6 1.0 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 ETN98931.1 - 0.051 13.9 23.2 0.057 13.7 23.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Afi1 PF07792.12 ETN98931.1 - 0.072 13.6 16.2 0.087 13.3 16.2 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Tim54 PF11711.8 ETN98931.1 - 0.083 11.7 14.8 0.086 11.6 14.8 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5308 PF17233.2 ETN98931.1 - 0.098 12.9 2.8 0.11 12.7 2.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Connexin PF00029.19 ETN98931.1 - 0.13 12.0 12.9 0.16 11.7 12.9 1.0 1 0 0 1 1 1 0 Connexin BSMAP PF12280.8 ETN98931.1 - 0.17 12.1 3.7 0.2 11.8 3.7 1.1 1 0 0 1 1 1 0 Brain specific membrane anchored protein SpoIIP PF07454.11 ETN98931.1 - 0.21 11.0 14.8 0.23 10.9 14.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF789 PF05623.12 ETN98931.1 - 0.23 11.1 10.9 0.25 11.0 10.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) DUF3438 PF11920.8 ETN98931.1 - 0.23 10.6 5.9 0.3 10.3 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) TRAP_alpha PF03896.16 ETN98931.1 - 0.25 10.5 12.6 0.27 10.4 12.6 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CPSF100_C PF13299.6 ETN98931.1 - 0.26 11.4 12.6 0.36 11.0 12.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 ETN98931.1 - 0.29 9.4 22.8 0.3 9.3 22.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Peroxin-13_N PF04088.13 ETN98931.1 - 0.31 11.3 1.6 0.39 11.0 1.6 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Astro_capsid_p PF12226.8 ETN98931.1 - 0.38 9.9 14.4 0.45 9.6 14.4 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF913 PF06025.12 ETN98931.1 - 0.38 9.7 8.8 0.39 9.7 8.8 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CLN3 PF02487.17 ETN98931.1 - 0.39 9.7 5.0 0.44 9.5 5.0 1.0 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 ETN98931.1 - 0.39 10.5 17.1 0.42 10.4 17.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RPN2_C PF18004.1 ETN98931.1 - 0.52 10.2 20.8 0.66 9.9 20.8 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain PTPRCAP PF15713.5 ETN98931.1 - 0.53 10.6 16.8 0.59 10.4 16.8 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SpoIIIAH PF12685.7 ETN98931.1 - 0.55 10.0 15.3 0.59 9.9 15.3 1.0 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF4637 PF15470.6 ETN98931.1 - 0.6 9.8 16.0 0.8 9.4 16.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) ATP-synt_E PF05680.12 ETN98931.1 - 0.65 10.4 9.8 1 9.8 9.8 1.3 1 0 0 1 1 1 0 ATP synthase E chain Zip PF02535.22 ETN98931.1 - 0.84 8.8 8.0 0.92 8.7 8.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC27 PF09507.10 ETN98931.1 - 0.86 8.9 23.7 0.92 8.8 23.7 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4770 PF15994.5 ETN98931.1 - 0.88 9.8 10.1 1.1 9.5 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) TFIIF_alpha PF05793.12 ETN98931.1 - 0.88 8.1 28.5 0.89 8.1 28.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNA_pol_Rpc4 PF05132.14 ETN98931.1 - 1 9.8 16.8 1.3 9.5 16.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 ETN98931.1 - 1.2 7.1 22.0 1.3 7.0 22.0 1.0 1 0 0 1 1 1 0 DNA polymerase phi Atrophin-1 PF03154.15 ETN98931.1 - 1.2 7.3 17.4 1.4 7.1 17.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF2428 PF10350.9 ETN98931.1 - 1.9 7.7 5.8 2.3 7.4 5.8 1.2 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) DUF2956 PF11169.8 ETN98931.1 - 2.3 8.4 14.0 3.2 8.0 14.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DDHD PF02862.17 ETN98931.1 - 2.8 8.1 8.3 3.1 7.9 8.3 1.1 1 0 0 1 1 1 0 DDHD domain EOS1 PF12326.8 ETN98931.1 - 2.9 7.8 5.2 3.4 7.6 5.2 1.1 1 0 0 1 1 1 0 N-glycosylation protein PPL5 PF18168.1 ETN98931.1 - 3.1 7.0 11.1 3.3 6.9 11.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF3537 PF12056.8 ETN98931.1 - 3.1 6.5 4.7 3.7 6.3 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) SAPS PF04499.15 ETN98931.1 - 3.4 6.3 12.3 3.5 6.3 12.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2151 PF10221.9 ETN98931.1 - 3.4 6.1 15.1 3.4 6.2 15.1 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Presenilin PF01080.17 ETN98931.1 - 3.7 6.2 12.6 3.7 6.2 12.6 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETN98931.1 - 3.9 6.2 15.2 3.9 6.2 15.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCM_bind PF09739.9 ETN98931.1 - 4.2 5.7 12.6 4.6 5.6 12.6 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor YqfQ PF14181.6 ETN98931.1 - 4.6 7.4 17.4 5.6 7.1 17.4 1.1 1 0 0 1 1 1 0 YqfQ-like protein CSG2 PF16965.5 ETN98931.1 - 5 6.0 4.4 5.3 5.9 4.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator GNAT_acetyltr_2 PF13718.6 ETN98931.1 - 5.2 6.4 7.7 6.1 6.2 7.7 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Paf1 PF03985.13 ETN98931.1 - 6.3 5.7 27.2 7.8 5.4 27.2 1.1 1 0 0 1 1 1 0 Paf1 AIF_C PF14721.6 ETN98931.1 - 6.7 7.1 10.0 7.9 6.8 10.0 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RRN3 PF05327.11 ETN98931.1 - 7.8 4.9 17.0 8.1 4.9 17.0 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Mem_trans PF03547.18 ETN98931.1 - 7.9 4.8 9.1 8.6 4.6 9.1 1.0 1 0 0 1 1 1 0 Membrane transport protein Roughex PF06020.11 ETN98931.1 - 9.8 5.2 12.6 11 5.0 12.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF4661 PF15576.6 ETN98932.1 - 0.39 10.6 3.3 0.43 10.4 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) DUF445 PF04286.12 ETN98932.1 - 0.69 9.6 5.0 0.78 9.5 5.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Kelch_6 PF13964.6 ETN98934.1 - 0.02 15.2 0.2 0.6 10.5 0.0 3.0 2 1 1 3 3 3 0 Kelch motif PulA_N1 PF17999.1 ETN98934.1 - 0.16 12.7 0.5 1.1 10.1 0.1 2.1 2 0 0 2 2 2 0 Pullulanase N1-terminal domain DUF2315 PF10231.9 ETN98936.1 - 8.2 6.5 11.6 1.3 9.1 0.1 4.1 4 0 0 4 4 4 0 Apoptogenic protein 1 PT PF04886.12 ETN98937.1 - 1.8e-95 312.1 470.7 2.3e-07 30.2 17.8 21.3 2 1 12 14 14 14 12 PT repeat ASL_C PF08328.11 ETN98938.1 - 0.32 11.1 4.5 0.2 11.7 0.2 2.7 2 1 0 2 2 2 0 Adenylosuccinate lyase C-terminal Orthopox_A47 PF06334.11 ETN98939.1 - 0.016 14.5 0.5 0.063 12.5 0.1 2.1 1 1 1 3 3 3 0 Orthopoxvirus A47 protein XRCC4 PF06632.12 ETN98940.1 - 0.019 13.8 0.1 0.024 13.5 0.1 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Sec6 PF06046.13 ETN98940.1 - 0.049 12.0 0.4 0.053 11.9 0.4 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec6 CMAS PF02353.20 ETN98940.1 - 0.094 12.0 0.2 0.11 11.8 0.2 1.0 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF3698 PF12479.8 ETN98941.1 - 0.24 11.9 3.7 0.23 12.0 2.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3698) zf-RING_7 PF02591.15 ETN98942.1 - 0.031 14.4 0.2 0.11 12.7 0.2 2.0 1 0 0 1 1 1 0 C4-type zinc ribbon domain HTS PF04204.16 ETN98942.1 - 0.11 11.5 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 Homoserine O-succinyltransferase Tubulin PF00091.25 ETN98943.1 - 5.9e-29 101.7 0.2 3.4e-22 79.6 0.1 2.5 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETN98943.1 - 9.3e-09 35.5 0.2 4e-08 33.5 0.0 2.1 2 0 0 2 2 2 1 Tubulin C-terminal domain DEP PF00610.21 ETN98944.1 - 2.7e-18 65.8 0.2 4.7e-11 42.6 0.0 2.7 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_7 PF13499.6 ETN98944.1 - 0.00016 22.0 1.9 0.00023 21.5 0.2 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_10 PF14788.6 ETN98944.1 - 0.0014 18.4 0.5 0.96 9.4 0.0 3.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETN98944.1 - 0.0019 18.0 0.2 2.5 8.3 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETN98944.1 - 0.0086 15.6 0.2 4.6 7.0 0.1 2.6 2 0 0 2 2 2 2 EF hand WD40 PF00400.32 ETN98945.1 - 2.1e-05 25.2 0.8 0.00016 22.4 0.6 2.4 2 2 0 2 2 2 1 WD domain, G-beta repeat DUF3683 PF12447.8 ETN98946.1 - 0.047 13.8 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3683) TPR_8 PF13181.6 ETN98947.1 - 0.12 12.7 8.0 0.14 12.4 3.9 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat Pox_RNA_Pol_19 PF05320.12 ETN98947.1 - 0.68 9.9 5.9 0.74 9.8 2.1 2.1 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit TPR_6 PF13174.6 ETN98947.1 - 5.4 7.9 6.3 3.2 8.6 1.2 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETN98948.1 - 0.066 14.1 0.0 0.11 13.4 0.0 1.4 1 0 0 1 1 1 0 WD domain, G-beta repeat Acetyltransf_18 PF18014.1 ETN98950.1 - 0.046 13.6 0.0 0.066 13.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain ANAPC4_WD40 PF12894.7 ETN98951.1 - 4.6e-08 33.2 0.1 0.18 12.1 0.0 4.3 1 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETN98951.1 - 3.8e-06 26.7 0.3 2.2 8.3 0.0 4.7 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETN98951.1 - 0.0033 18.2 0.8 18 6.4 0.0 4.5 5 0 0 5 5 5 1 WD domain, G-beta repeat Coatomer_WDAD PF04053.14 ETN98951.1 - 0.014 14.5 1.1 2.9 6.8 0.4 2.4 1 1 1 2 2 2 0 Coatomer WD associated region Proteasome_A_N PF10584.9 ETN98951.1 - 3.5 7.4 6.2 16 5.3 0.2 4.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature LRR_4 PF12799.7 ETN98952.1 - 0.032 14.7 1.3 0.084 13.3 0.3 2.2 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) DASH_Duo1 PF08651.10 ETN98954.1 - 0.0044 16.7 1.2 0.0064 16.2 0.3 1.7 2 0 0 2 2 2 1 DASH complex subunit Duo1 Glyco_hydro_77 PF02446.17 ETN98954.1 - 0.0078 15.1 0.1 0.01 14.7 0.1 1.2 1 0 0 1 1 1 1 4-alpha-glucanotransferase Sod_Ni PF09055.11 ETN98954.1 - 0.079 13.5 3.8 0.095 13.3 0.5 2.3 2 1 1 3 3 3 0 Nickel-containing superoxide dismutase Afaf PF15339.6 ETN98956.1 - 0.016 14.9 0.2 0.019 14.7 0.2 1.0 1 0 0 1 1 1 0 Acrosome formation-associated factor SPOB_ab PF14682.6 ETN98956.1 - 0.039 14.0 0.1 0.049 13.7 0.1 1.1 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal zf-RVT PF13966.6 ETN98959.1 - 6.2e-05 23.6 1.5 6.2e-05 23.6 1.5 2.3 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase zf-CCHC PF00098.23 ETN98959.1 - 0.00055 19.9 1.7 0.00055 19.9 1.7 3.1 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 ETN98959.1 - 1.1 9.1 11.5 0.7 9.7 1.2 3.1 3 0 0 3 3 3 0 Zinc knuckle TPR_12 PF13424.6 ETN98961.1 - 2.4e-21 75.8 1.0 3.6e-21 75.2 0.6 1.5 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN98961.1 - 7.5e-20 70.2 1.7 3.4e-11 42.6 0.3 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN98961.1 - 1.5e-16 59.4 6.6 8.2e-11 41.2 1.5 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN98961.1 - 2.2e-16 58.6 1.2 3.5e-10 39.2 0.2 2.6 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN98961.1 - 2.4e-14 52.2 7.8 7.9e-10 38.2 1.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN98961.1 - 3.5e-14 51.7 5.1 2.2e-08 33.6 0.7 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN98961.1 - 3.8e-10 39.4 2.7 1.7e-05 24.8 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN98961.1 - 8e-09 36.0 0.0 2.1e-05 25.1 0.0 2.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETN98961.1 - 2.9e-08 33.5 3.1 0.0006 19.8 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN98961.1 - 2.8e-07 30.8 0.0 0.012 16.4 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat PPR PF01535.20 ETN98961.1 - 7.8e-06 25.8 1.9 0.0008 19.5 0.1 2.9 3 0 0 3 3 3 1 PPR repeat TPR_11 PF13414.6 ETN98961.1 - 2.1e-05 24.1 11.5 0.0046 16.6 2.2 3.7 1 1 2 3 3 3 3 TPR repeat DUF5113 PF17140.4 ETN98961.1 - 7e-05 22.7 1.5 0.018 14.9 0.3 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETN98961.1 - 0.0002 21.8 0.2 0.039 14.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN98961.1 - 0.013 15.7 3.7 2.7 8.3 0.3 2.7 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF3450 PF11932.8 ETN98961.1 - 0.013 14.8 0.3 1 8.6 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HTH_Bact PF18768.1 ETN98961.1 - 0.022 14.4 3.2 1.4 8.5 0.3 2.7 2 1 1 3 3 3 0 Helix-turn-helix bacterial domain MIT PF04212.18 ETN98961.1 - 0.029 14.4 0.9 0.029 14.4 0.9 1.9 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETN98961.1 - 0.029 13.8 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 ETN98961.1 - 0.031 13.7 0.0 0.034 13.5 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region RPN7 PF10602.9 ETN98961.1 - 0.058 13.1 0.9 0.14 11.8 0.2 1.8 1 1 1 2 2 2 0 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 ETN98961.1 - 0.1 12.7 5.0 2.4 8.3 0.4 2.3 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat DUF357 PF04010.13 ETN98961.1 - 0.11 12.6 2.4 5.5 7.1 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF357) PPR_2 PF13041.6 ETN98961.1 - 0.13 12.5 0.4 1.2 9.4 0.0 2.4 3 0 0 3 3 3 0 PPR repeat family DSPc PF00782.20 ETN98962.1 - 5.8e-13 48.8 0.0 7.3e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETN98962.1 - 2.6e-05 23.9 0.3 4.3e-05 23.2 0.2 1.4 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETN98962.1 - 0.00048 20.3 0.0 0.00048 20.3 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ETN98962.1 - 0.017 15.1 0.0 0.019 14.9 0.0 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ETN98962.1 - 0.064 12.8 0.0 0.073 12.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family RE_HindVP PF09519.10 ETN98962.1 - 0.065 12.3 0.0 0.077 12.0 0.0 1.1 1 0 0 1 1 1 0 HindVP restriction endonuclease SAC3 PF12209.8 ETN98965.1 - 0.0032 17.6 0.3 0.0066 16.6 0.3 1.4 1 0 0 1 1 1 1 Leucine permease transcriptional regulator helical domain v110 PF01639.17 ETN98965.1 - 0.071 13.0 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Viral family 110 PT PF04886.12 ETN98966.1 - 4.3e-17 61.4 68.3 0.0002 20.8 3.9 4.9 1 1 1 2 2 2 1 PT repeat DUF3071 PF11268.8 ETN98967.1 - 0.06 13.4 1.8 0.072 13.2 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3071) DUF883 PF05957.13 ETN98967.1 - 1.4 9.6 4.2 2.2 8.9 0.8 2.1 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) LMBR1 PF04791.16 ETN98967.1 - 3.4 6.5 7.8 3.9 6.3 7.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein SCVP PF17619.2 ETN98969.1 - 0.096 13.6 0.1 0.15 12.9 0.1 1.3 1 0 0 1 1 1 0 Secreted clade V proteins DUF1699 PF08004.11 ETN98970.1 - 0.0048 16.6 0.1 2.9 7.6 0.0 2.2 1 1 1 2 2 2 2 Protein of unknown function (DUF1699) FrpC PF06901.12 ETN98970.1 - 0.068 12.8 0.0 0.1 12.2 0.0 1.3 1 1 0 1 1 1 0 RTX iron-regulated protein FrpC Nro1 PF12753.7 ETN98971.1 - 0.026 13.5 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 dUTPase PF00692.19 ETN98973.1 - 4e-36 123.6 0.0 2e-24 85.7 0.0 2.1 2 0 0 2 2 2 2 dUTPase MSG PF02349.15 ETN98974.1 - 0.023 14.9 9.8 0.048 13.9 9.8 1.5 1 0 0 1 1 1 0 Major surface glycoprotein WD40 PF00400.32 ETN98975.1 - 0.00067 20.4 0.7 0.005 17.6 1.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF908 PF06012.12 ETN98976.1 - 0.00065 19.2 0.6 0.00069 19.1 0.6 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) Ctr PF04145.15 ETN98976.1 - 0.008 16.8 2.0 0.0092 16.6 2.0 1.2 1 0 0 1 1 1 1 Ctr copper transporter family YmaF PF12788.7 ETN98976.1 - 0.025 15.1 0.7 0.025 15.1 0.7 2.3 1 1 1 2 2 2 0 YmaF family Ribosomal_L18_c PF14204.6 ETN98976.1 - 0.13 13.2 9.0 0.19 12.7 9.0 1.4 1 0 0 1 1 1 0 Ribosomal L18 C-terminal region CAP_GLY PF01302.25 ETN98977.1 - 0.078 13.0 0.0 0.28 11.2 0.0 1.8 2 0 0 2 2 2 0 CAP-Gly domain TPR_12 PF13424.6 ETN98980.1 - 3.6e-07 30.4 0.0 0.0021 18.3 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat WD40 PF00400.32 ETN98982.1 - 5.3e-19 68.2 6.0 1.3e-06 29.0 0.2 4.0 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98982.1 - 1.3e-10 41.5 0.1 7.6e-06 26.1 0.0 3.0 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98982.1 - 6.8e-09 34.9 0.3 9.1e-07 27.9 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Med21 PF11221.8 ETN98983.1 - 0.019 15.2 1.0 0.31 11.3 0.4 2.3 2 0 0 2 2 2 0 Subunit 21 of Mediator complex VPR PF00522.18 ETN98983.1 - 0.21 11.6 2.1 1.7 8.7 0.5 2.4 2 0 0 2 2 2 0 VPR/VPX protein WD40 PF00400.32 ETN98987.1 - 4.2e-52 173.0 28.0 1.3e-08 35.3 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98987.1 - 1.2e-18 67.2 7.0 0.092 13.0 0.1 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98987.1 - 3.1e-12 46.1 4.3 0.12 11.3 0.0 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETN98987.1 - 2.9e-08 32.6 0.3 0.00067 18.3 0.0 3.7 1 1 3 4 4 4 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETN98987.1 - 7.7e-08 32.0 4.9 0.00036 20.0 0.4 3.5 1 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETN98987.1 - 2.4e-07 29.8 6.1 0.013 14.2 0.1 5.0 1 1 4 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETN98987.1 - 7.4e-05 21.7 12.5 0.019 13.7 1.4 4.6 1 1 5 6 6 6 3 Nup133 N terminal like VID27 PF08553.10 ETN98987.1 - 0.0017 17.5 0.1 0.042 12.9 0.1 2.5 1 1 2 3 3 3 1 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETN98987.1 - 0.02 14.8 1.6 14 5.8 0.0 4.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat S6PP PF05116.13 ETN98988.1 - 0.00097 18.7 0.9 0.0055 16.3 0.0 2.0 1 1 1 2 2 2 1 Sucrose-6F-phosphate phosphohydrolase WD40 PF00400.32 ETN98989.1 - 4.1e-26 90.7 16.3 4.5e-08 33.6 0.3 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98989.1 - 3e-07 30.6 0.4 0.0023 18.2 0.0 4.0 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98989.1 - 2.5e-06 26.4 0.9 0.015 13.9 0.1 3.3 3 0 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN98989.1 - 1.8e-05 24.3 9.7 0.03 13.6 1.4 3.6 2 2 1 4 4 4 2 WD40-like domain W_rich_C PF07483.11 ETN98989.1 - 0.091 12.9 3.5 4.6 7.5 0.3 2.9 2 1 1 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain RhoGAP PF00620.27 ETN98990.1 - 0.00045 20.1 0.0 0.00076 19.3 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Virulence_fact PF13769.6 ETN98991.1 - 0.014 15.6 1.3 0.044 14.0 0.2 2.0 1 1 1 2 2 2 0 Virulence factor Exo_endo_phos_2 PF14529.6 ETN98992.1 - 5.3e-05 23.0 0.3 8.5e-05 22.4 0.3 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Peptidase_C36 PF05415.11 ETN98992.1 - 0.067 13.4 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase WD40 PF00400.32 ETN98993.1 - 2e-15 56.9 7.1 7.3e-07 29.8 0.4 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98993.1 - 0.00022 21.4 0.2 0.00077 19.7 0.0 1.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S66 PF02016.15 ETN98993.1 - 0.017 15.2 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain BLF1 PF17752.1 ETN98993.1 - 0.018 14.3 0.2 0.029 13.7 0.2 1.3 1 0 0 1 1 1 0 Burkholderia lethal factor 1 DNA_PPF PF02916.15 ETN98993.1 - 0.039 14.3 0.2 0.076 13.4 0.2 1.4 1 0 0 1 1 1 0 DNA polymerase processivity factor WD40 PF00400.32 ETN98994.1 - 5.8e-13 49.1 5.6 8.8e-07 29.5 0.2 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN98994.1 - 0.00041 19.1 0.3 0.0013 17.5 0.3 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN98994.1 - 0.0011 19.3 0.0 0.0055 17.0 0.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S66 PF02016.15 ETN98994.1 - 0.01 16.0 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 0 LD-carboxypeptidase N-terminal domain DUF4221 PF13970.6 ETN98994.1 - 0.19 11.3 9.7 0.7 9.4 9.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4221) WD40 PF00400.32 ETN98995.1 - 2e-26 91.7 0.6 2.3e-09 37.7 0.0 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETN98995.1 - 1e-09 37.8 0.1 1.8e-06 27.1 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETN98995.1 - 9.8e-08 32.2 0.1 0.0058 16.9 0.1 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN98995.1 - 0.0027 16.4 0.0 0.59 8.7 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETN98995.1 - 0.012 14.4 0.2 0.36 9.5 0.1 2.0 1 1 1 2 2 2 0 Nup133 N terminal like WD40_like PF17005.5 ETN98995.1 - 0.019 14.3 0.0 1.5 8.0 0.0 2.6 1 1 2 3 3 3 0 WD40-like domain PD40 PF07676.12 ETN98995.1 - 0.05 13.6 0.0 40 4.3 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat RAB3GAP2_N PF14655.6 ETN98995.1 - 0.065 12.5 0.1 0.081 12.2 0.1 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF5570 PF17731.1 ETN98995.1 - 0.17 12.0 0.0 12 6.0 0.0 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF5570) Peptidase_C14 PF00656.22 ETN98996.1 - 2e-15 57.4 0.4 2.6e-15 57.1 0.4 1.1 1 0 0 1 1 1 1 Caspase domain Rep_fac_C PF08542.11 ETN98996.1 - 0.07 13.5 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Replication factor C C-terminal domain DUF2722 PF10846.8 ETN98997.1 - 0.1 11.5 13.1 0.12 11.3 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) PHD_4 PF16866.5 ETN98997.1 - 0.39 10.8 3.5 0.74 9.9 3.5 1.4 1 0 0 1 1 1 0 PHD-finger Corona_nucleoca PF00937.18 ETN98997.1 - 0.41 9.6 12.1 0.5 9.3 12.1 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein CMV_US PF08001.11 ETN98997.1 - 0.89 8.8 3.4 1.3 8.3 3.4 1.2 1 0 0 1 1 1 0 CMV US WD40 PF00400.32 ETN98998.1 - 2.2e-25 88.4 1.2 1.6e-11 44.6 0.1 2.0 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN98998.1 - 3.5e-05 24.0 0.0 0.0018 18.5 0.0 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN98998.1 - 6e-05 22.2 0.0 0.16 10.9 0.0 2.0 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN98998.1 - 0.0045 16.9 0.1 1.3 9.1 0.0 2.3 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat DUF2415 PF10313.9 ETN98998.1 - 0.045 13.7 0.0 0.28 11.2 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) TMCO5 PF14992.6 ETN98999.1 - 0.0074 15.9 0.9 0.013 15.1 0.9 1.4 1 0 0 1 1 1 1 TMCO5 family BLOC1_2 PF10046.9 ETN98999.1 - 0.051 13.9 0.3 0.12 12.7 0.3 1.6 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 THOC7 PF05615.13 ETN98999.1 - 0.065 13.5 0.4 0.13 12.5 0.4 1.4 1 0 0 1 1 1 0 Tho complex subunit 7 TSC22 PF01166.18 ETN98999.1 - 0.12 12.7 2.0 0.6 10.5 0.3 2.6 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF3573 PF12097.8 ETN98999.1 - 0.21 10.4 0.0 0.27 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DivIC PF04977.15 ETN98999.1 - 0.45 10.3 2.0 2.7 7.8 0.2 2.2 1 1 1 2 2 2 0 Septum formation initiator DUF3194 PF11419.8 ETN99000.1 - 0.0015 18.9 0.6 0.016 15.5 0.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3194) NPR3 PF03666.13 ETN99002.1 - 0.77 8.5 9.0 0.82 8.4 9.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5532 PF17673.1 ETN99003.1 - 0.011 15.8 1.0 0.016 15.3 1.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5532) AAA PF00004.29 ETN99004.1 - 0.0046 17.4 0.0 0.0079 16.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETN99004.1 - 0.013 15.5 0.0 0.33 10.9 0.0 2.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETN99004.1 - 0.016 15.5 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETN99004.1 - 0.12 12.8 0.0 0.32 11.4 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain Kelch_4 PF13418.6 ETN99007.1 - 5.6e-07 29.5 1.1 0.00062 19.7 0.2 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99007.1 - 0.00014 21.4 0.9 0.02 14.4 0.5 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETN99007.1 - 0.015 15.3 2.4 1.5 8.9 0.3 3.7 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETN99007.1 - 0.021 15.1 6.6 1.7 9.0 0.0 3.6 4 0 0 4 4 4 0 Kelch motif SRP-alpha_N PF04086.13 ETN99008.1 - 0.043 13.7 38.4 0.062 13.2 38.4 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal N6_Mtase PF02384.16 ETN99009.1 - 6.1e-21 75.0 0.1 6.6e-21 74.9 0.1 1.0 1 0 0 1 1 1 1 N-6 DNA Methylase UPF0020 PF01170.18 ETN99009.1 - 0.012 15.3 0.0 0.017 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 MTS PF05175.14 ETN99009.1 - 0.03 13.9 0.0 0.042 13.4 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase small domain AviRa PF11599.8 ETN99009.1 - 0.085 12.3 0.0 0.097 12.1 0.0 1.2 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Kelch_4 PF13418.6 ETN99010.1 - 1.4e-06 28.2 0.1 7.7e-06 25.8 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99010.1 - 4.3e-05 23.0 0.0 0.0026 17.3 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN99010.1 - 0.00075 19.7 1.4 0.0078 16.5 0.1 3.0 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETN99010.1 - 0.0032 17.7 0.0 0.0082 16.4 0.0 1.7 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN99010.1 - 0.034 14.1 0.2 0.17 11.9 0.1 2.1 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETN99010.1 - 0.17 11.9 1.4 0.42 10.6 0.2 2.2 2 0 0 2 2 2 0 Kelch motif AC_N PF16214.5 ETN99011.1 - 0.19 10.9 0.1 0.3 10.2 0.1 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF1330 PF07045.11 ETN99012.1 - 0.03 14.6 0.1 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) Helicase_C PF00271.31 ETN99012.1 - 0.11 12.8 0.7 1.3 9.4 0.5 2.6 1 1 0 1 1 1 0 Helicase conserved C-terminal domain Helicase_C_2 PF13307.6 ETN99012.1 - 0.13 12.5 1.1 0.2 11.8 0.1 1.8 2 0 0 2 2 2 0 Helicase C-terminal domain EamA PF00892.20 ETN99013.1 - 5.2e-05 23.4 6.4 6.8e-05 23.1 6.4 1.2 1 0 0 1 1 1 1 EamA-like transporter family DUF1361 PF07099.11 ETN99013.1 - 0.092 12.7 3.7 0.39 10.7 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1361) DUF2808 PF10989.8 ETN99014.1 - 0.022 14.8 0.2 0.043 13.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2808) Phage_TAC_2 PF06894.11 ETN99014.1 - 0.029 14.2 0.2 0.088 12.6 0.1 1.7 1 1 1 2 2 2 0 Bacteriophage lambda tail assembly chaperone, TAC, protein G Cation_efflux PF01545.21 ETN99015.1 - 0.0054 16.5 6.3 0.0075 16.0 6.3 1.2 1 0 0 1 1 1 1 Cation efflux family zf-C3HC4_3 PF13920.6 ETN99018.1 - 3.2e-10 39.7 8.7 7.4e-10 38.5 8.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETN99018.1 - 1e-06 29.0 10.3 1.4e-06 28.5 8.6 2.2 2 0 0 2 2 2 1 Ring finger domain FHA PF00498.26 ETN99018.1 - 3.8e-06 27.2 0.2 7.2e-06 26.3 0.2 1.5 1 0 0 1 1 1 1 FHA domain Prok-RING_4 PF14447.6 ETN99018.1 - 3.8e-06 26.7 8.9 1e-05 25.3 8.9 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ETN99018.1 - 4.9e-05 23.1 13.0 5.1e-05 23.1 9.6 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETN99018.1 - 0.00024 20.9 10.3 0.00072 19.4 8.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETN99018.1 - 0.00043 20.2 9.5 0.00043 20.2 9.5 2.4 2 1 0 2 2 2 1 zinc-RING finger domain Yop-YscD_cpl PF16697.5 ETN99018.1 - 0.0013 19.0 0.1 0.0033 17.7 0.1 1.6 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_4 PF15227.6 ETN99018.1 - 0.043 14.0 5.7 0.36 11.0 5.1 2.7 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ETN99018.1 - 0.08 12.7 7.4 0.16 11.8 6.3 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 ETN99018.1 - 0.83 9.7 11.3 0.84 9.7 7.1 2.8 3 0 0 3 3 3 0 RING-type zinc-finger zf-rbx1 PF12678.7 ETN99018.1 - 1.3 9.3 9.1 2.7 8.3 7.8 2.2 2 0 0 2 2 2 0 RING-H2 zinc finger domain GET2 PF08690.10 ETN99019.1 - 0.021 14.5 1.5 0.029 14.0 1.5 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF913 PF06025.12 ETN99019.1 - 0.029 13.3 0.4 0.037 13.0 0.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PTPRCAP PF15713.5 ETN99019.1 - 0.056 13.7 6.6 0.076 13.3 6.6 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Pox_Ag35 PF03286.14 ETN99019.1 - 0.062 13.1 7.2 0.087 12.6 7.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM60A PF15396.6 ETN99019.1 - 0.11 12.5 2.5 0.15 12.0 2.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CSG2 PF16965.5 ETN99019.1 - 0.14 11.1 0.2 0.16 10.9 0.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CDC45 PF02724.14 ETN99019.1 - 0.77 8.0 8.3 0.98 7.6 8.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CRA PF06589.11 ETN99019.1 - 2.5 8.2 9.1 4.1 7.5 9.1 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) FAM176 PF14851.6 ETN99019.1 - 4.1 7.1 9.2 7.5 6.2 9.2 1.5 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 ETN99019.1 - 6.5 5.4 7.0 8.4 5.0 7.0 1.1 1 0 0 1 1 1 0 Presenilin Na_Ca_ex PF01699.24 ETN99020.1 - 1.5e-06 28.2 20.1 0.00011 22.1 6.3 2.2 2 0 0 2 2 2 2 Sodium/calcium exchanger protein Cyt_bd_oxida_II PF02322.15 ETN99020.1 - 0.00053 19.4 1.9 0.0046 16.4 0.6 2.0 2 0 0 2 2 2 1 Cytochrome bd terminal oxidase subunit II DUF2207 PF09972.9 ETN99020.1 - 3.6 6.2 8.6 21 3.7 8.6 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Kelch_6 PF13964.6 ETN99021.1 - 0.0019 18.4 0.0 0.003 17.8 0.0 1.2 1 0 0 1 1 1 1 Kelch motif NTP_transf_7 PF07984.12 ETN99021.1 - 0.036 13.3 0.2 0.043 13.0 0.2 1.1 1 0 0 1 1 1 0 Nucleotidyltransferase Kelch_5 PF13854.6 ETN99021.1 - 0.052 13.6 0.0 0.093 12.7 0.0 1.5 1 0 0 1 1 1 0 Kelch motif GF_recep_IV PF14843.6 ETN99021.1 - 0.083 12.7 0.1 0.1 12.4 0.1 1.1 1 0 0 1 1 1 0 Growth factor receptor domain IV BCIP PF13862.6 ETN99022.1 - 0.011 15.5 0.5 0.017 14.9 0.5 1.2 1 0 0 1 1 1 0 p21-C-terminal region-binding protein DUF1115 PF06544.12 ETN99025.1 - 0.1 12.7 3.2 0.12 12.5 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) DUF4701 PF15773.5 ETN99026.1 - 0.0048 16.0 2.1 0.0065 15.5 2.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4701) TehB PF03848.14 ETN99026.1 - 0.019 14.3 0.2 0.041 13.3 0.2 1.5 1 0 0 1 1 1 0 Tellurite resistance protein TehB SAM_1 PF00536.30 ETN99028.1 - 6.6e-06 26.5 0.0 1.2e-05 25.6 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN99028.1 - 9.9e-05 22.4 0.0 0.00021 21.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF5403 PF17395.2 ETN99028.1 - 0.21 11.9 3.9 0.4 11.0 3.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5403) Hid1 PF12722.7 ETN99028.1 - 5.2 5.1 12.9 6.8 4.7 12.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Y_phosphatase2 PF03162.13 ETN99029.1 - 4.6e-48 162.9 0.0 1e-47 161.8 0.0 1.5 1 1 1 2 2 2 1 Tyrosine phosphatase family DSPc PF00782.20 ETN99029.1 - 0.00069 19.4 0.2 0.0031 17.3 0.0 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETN99029.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ETN99029.1 - 0.0015 18.2 0.0 0.0036 16.9 0.0 1.6 2 0 0 2 2 2 1 Protein-tyrosine phosphatase KCNQ2_u3 PF16642.5 ETN99029.1 - 0.1 13.6 0.9 0.19 12.7 0.9 1.5 1 0 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 ubiquitin PF00240.23 ETN99031.1 - 0.067 12.9 1.0 0.15 11.9 0.3 1.9 2 0 0 2 2 2 0 Ubiquitin family HemY_N PF07219.13 ETN99031.1 - 8.5 6.6 8.0 0.4 10.9 1.5 2.0 2 0 0 2 2 2 0 HemY protein N-terminus DUF3524 PF12038.8 ETN99032.1 - 4.7e-16 59.1 1.5 8.6e-15 55.0 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3524) Glycos_transf_1 PF00534.20 ETN99032.1 - 6.4e-09 35.6 0.0 1e-08 34.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETN99032.1 - 0.0031 17.9 0.0 0.005 17.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Methyltransf_12 PF08242.12 ETN99033.1 - 7.4e-10 39.5 0.0 1.1e-09 38.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETN99033.1 - 1.9e-09 38.1 0.0 3.1e-09 37.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETN99033.1 - 3.1e-08 33.2 0.0 4.8e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_28 PF02636.17 ETN99033.1 - 4.3e-06 26.6 0.0 6.1e-06 26.0 0.0 1.3 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Methyltransf_5 PF01795.19 ETN99033.1 - 6.4e-06 25.9 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 MraW methylase family Methyltransf_11 PF08241.12 ETN99033.1 - 2.9e-05 24.6 0.0 4.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_33 PF10017.9 ETN99033.1 - 9.5e-05 21.7 0.0 0.00013 21.3 0.0 1.1 1 0 0 1 1 1 1 Histidine-specific methyltransferase, SAM-dependent Methyltransf_31 PF13847.6 ETN99033.1 - 0.0003 20.6 0.0 0.00036 20.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETN99033.1 - 0.00079 19.4 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ETN99033.1 - 0.00092 18.7 0.0 0.0013 18.2 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase PCMT PF01135.19 ETN99033.1 - 0.021 14.6 0.0 0.03 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 ETN99033.1 - 0.027 13.8 0.0 0.048 13.0 0.0 1.5 1 1 0 1 1 1 0 O-methyltransferase domain Methyltransf_23 PF13489.6 ETN99033.1 - 0.046 13.5 0.0 0.064 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain RrnaAD PF00398.20 ETN99033.1 - 0.052 12.6 0.0 0.067 12.3 0.0 1.2 1 0 0 1 1 1 0 Ribosomal RNA adenine dimethylase 4HPAD_g_N PF18671.1 ETN99033.1 - 0.084 12.6 0.0 0.22 11.3 0.0 1.7 1 0 0 1 1 1 0 4-Hydroxyphenylacetate decarboxylase subunit gamma N-terminal DOT1 PF08123.13 ETN99033.1 - 0.091 12.3 0.0 0.15 11.6 0.0 1.4 1 1 0 1 1 1 0 Histone methylation protein DOT1 MTS PF05175.14 ETN99033.1 - 0.18 11.3 0.0 0.31 10.6 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Phage_ABA_S PF18066.1 ETN99034.1 - 0.16 12.7 0.4 0.57 10.9 0.4 1.9 1 0 0 1 1 1 0 Phage ABA sandwich domain DIT1_PvcA PF05141.12 ETN99034.1 - 0.92 8.9 5.4 0.3 10.5 0.7 2.1 2 0 0 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein OPT PF03169.15 ETN99036.1 - 0.061 11.9 0.4 0.065 11.8 0.4 1.0 1 0 0 1 1 1 0 OPT oligopeptide transporter protein YjbH PF06082.11 ETN99037.1 - 0.68 8.7 8.4 0.79 8.5 8.4 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH SDA1 PF05285.12 ETN99037.1 - 3.2 7.1 26.2 4.1 6.7 26.2 1.2 1 0 0 1 1 1 0 SDA1 BAF1_ABF1 PF04684.13 ETN99037.1 - 3.6 6.5 29.5 4.1 6.3 29.5 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor DNA_pol_phi PF04931.13 ETN99037.1 - 5 5.1 29.9 5.7 4.9 29.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ETN99040.1 - 1.5e-14 54.1 8.3 2e-09 37.9 0.1 3.3 2 1 1 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99040.1 - 1.8e-05 25.0 0.2 0.0002 21.6 0.2 2.4 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN99040.1 - 0.01 14.6 0.2 1.1 7.9 0.1 2.1 1 1 1 2 2 2 0 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETN99040.1 - 0.016 14.3 0.0 0.019 14.0 0.0 1.1 1 0 0 1 1 1 0 Coatomer WD associated region Nup160 PF11715.8 ETN99040.1 - 0.025 13.2 1.7 2.8 6.5 0.0 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 zf-C4H2 PF10146.9 ETN99042.1 - 0.001 19.4 2.2 0.0013 19.1 2.2 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein DUF2972 PF11186.8 ETN99042.1 - 0.0019 18.2 0.3 0.0021 18.0 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2972) ComR_TPR PF18710.1 ETN99044.1 - 0.032 13.8 0.3 0.032 13.8 0.3 1.8 2 0 0 2 2 2 0 ComR tetratricopeptide G0-G1_switch_2 PF15103.6 ETN99045.1 - 5.1 7.6 8.3 2.3 8.7 1.2 2.5 2 1 1 3 3 3 0 G0/G1 switch protein 2 DUF642 PF04862.12 ETN99047.1 - 0.11 12.2 1.5 0.16 11.7 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF642) Lig_chan PF00060.26 ETN99047.1 - 0.21 11.4 3.3 0.14 12.0 0.9 1.8 2 0 0 2 2 2 0 Ligand-gated ion channel GWT1 PF06423.12 ETN99047.1 - 8.2 6.5 16.7 4 7.5 3.8 3.1 1 1 2 3 3 3 0 GWT1 Kelch_1 PF01344.25 ETN99048.1 - 2e-09 36.9 0.8 0.00013 21.5 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETN99048.1 - 1.3e-05 25.0 0.5 0.11 12.5 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETN99048.1 - 2.1e-05 24.6 2.2 0.3 11.5 0.0 3.8 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETN99048.1 - 2.7e-05 24.1 0.2 0.016 15.2 0.0 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN99048.1 - 0.0016 18.4 3.3 0.59 10.2 0.0 3.6 4 1 0 4 4 4 2 Kelch motif DKNYY PF13644.6 ETN99048.1 - 0.027 15.3 0.5 0.053 14.3 0.5 1.5 1 1 0 1 1 1 0 DKNYY family WD40 PF00400.32 ETN99050.1 - 9.5e-20 70.6 0.7 5.2e-07 30.3 0.2 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99050.1 - 5.9e-10 39.3 0.3 0.0014 18.9 0.0 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99050.1 - 0.00054 19.4 0.1 0.00066 19.1 0.1 1.2 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETN99050.1 - 0.0088 15.0 0.2 1.3 7.9 0.0 2.0 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ETN99050.1 - 0.088 12.8 0.0 10 6.3 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat TFIIIC_delta PF12657.7 ETN99050.1 - 0.13 12.2 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Transcription factor IIIC subunit delta N-term Gp37 PF09646.10 ETN99051.1 - 0.022 14.6 0.0 0.025 14.4 0.0 1.1 1 0 0 1 1 1 0 Gp37 protein CAP_GLY PF01302.25 ETN99051.1 - 0.15 12.1 0.4 9.6 6.3 0.0 2.5 2 1 1 3 3 3 0 CAP-Gly domain RasGEF PF00617.19 ETN99053.1 - 1.8e-32 113.0 2.8 3.7e-32 112.0 2.8 1.6 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETN99053.1 - 6.9e-11 42.3 0.2 6.9e-11 42.3 0.2 2.8 3 0 0 3 3 3 1 RasGEF N-terminal motif Neugrin PF06413.11 ETN99053.1 - 0.061 13.3 3.8 0.21 11.6 3.8 1.9 1 0 0 1 1 1 0 Neugrin DUF448 PF04296.13 ETN99054.1 - 0.048 13.5 4.2 0.051 13.4 0.1 2.9 4 0 0 4 4 4 0 Protein of unknown function (DUF448) DZR PF12773.7 ETN99054.1 - 0.05 13.6 6.8 2.3 8.3 1.2 2.4 2 0 0 2 2 2 0 Double zinc ribbon RVT_1 PF00078.27 ETN99055.1 - 5.3e-06 26.1 0.1 1.8e-05 24.4 0.0 1.6 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) CDC73_N PF16050.5 ETN99055.1 - 0.13 11.6 0.1 0.16 11.3 0.1 1.1 1 0 0 1 1 1 0 Paf1 complex subunit CDC73 N-terminal CALM_bind PF16025.5 ETN99056.1 - 0.002 18.6 1.5 0.0031 17.9 1.5 1.3 1 0 0 1 1 1 1 Calcium-dependent calmodulin binding Atg14 PF10186.9 ETN99056.1 - 0.012 14.8 4.3 0.015 14.4 4.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EMC3_TMCO1 PF01956.16 ETN99056.1 - 0.015 15.1 0.2 0.019 14.7 0.2 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like SIL1 PF16782.5 ETN99059.1 - 0.012 14.8 0.4 0.018 14.2 0.4 1.2 1 0 0 1 1 1 0 Nucleotide exchange factor SIL1 Thioredoxin_6 PF13848.6 ETN99059.1 - 0.026 14.4 1.3 0.028 14.3 0.4 1.6 2 0 0 2 2 2 0 Thioredoxin-like domain N6-adenineMlase PF10237.9 ETN99059.1 - 0.12 12.2 3.2 0.21 11.4 2.1 1.9 1 1 0 1 1 1 0 Probable N6-adenine methyltransferase HSP90 PF00183.18 ETN99061.1 - 6.9e-11 41.7 9.6 1e-05 24.7 2.2 2.9 2 1 1 3 3 3 2 Hsp90 protein HMG_CoA_synt_N PF01154.17 ETN99062.1 - 0.15 11.9 0.0 0.19 11.6 0.0 1.2 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A synthase N terminal PDZ_6 PF17820.1 ETN99063.1 - 8.4e-07 28.7 0.0 7.8e-06 25.6 0.0 2.5 3 0 0 3 3 3 1 PDZ domain PDZ_2 PF13180.6 ETN99063.1 - 0.00027 21.2 0.1 0.00094 19.5 0.0 1.9 2 0 0 2 2 2 1 PDZ domain SAM_1 PF00536.30 ETN99063.1 - 0.00035 20.9 0.0 0.00086 19.7 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ PF00595.24 ETN99063.1 - 0.0005 20.4 0.0 0.0014 19.0 0.0 1.8 1 0 0 1 1 1 1 PDZ domain SAM_2 PF07647.17 ETN99063.1 - 0.0012 18.9 0.0 0.0027 17.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3069 PF11269.8 ETN99064.1 - 0.033 14.4 0.1 0.059 13.6 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3069) SDA1 PF05285.12 ETN99065.1 - 0.0044 16.5 8.0 0.0066 15.9 8.0 1.2 1 0 0 1 1 1 1 SDA1 RXT2_N PF08595.11 ETN99065.1 - 0.0065 16.5 5.6 0.0065 16.5 5.6 1.7 2 0 0 2 2 2 1 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 ETN99065.1 - 0.03 14.7 12.2 0.13 12.7 12.6 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain LAP1C PF05609.12 ETN99065.1 - 0.052 12.6 3.2 3.2 6.7 0.0 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) DUF4746 PF15928.5 ETN99065.1 - 0.28 10.6 9.5 0.53 9.6 9.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop14 PF04147.12 ETN99065.1 - 0.56 8.4 12.6 0.77 7.9 12.6 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ETN99065.1 - 1.3 7.1 18.6 1.7 6.6 18.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi SURF2 PF05477.11 ETN99065.1 - 1.4 8.6 5.8 2.5 7.7 5.8 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) TRAP_alpha PF03896.16 ETN99065.1 - 2.3 7.4 10.6 0.52 9.5 6.8 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 ETN99065.1 - 2.6 7.3 15.2 4.1 6.6 15.2 1.2 1 0 0 1 1 1 0 NOA36 protein XAP5 PF04921.14 ETN99065.1 - 7.7 6.3 8.3 1.4 8.7 4.4 1.6 2 0 0 2 2 2 0 XAP5, circadian clock regulator Pkinase PF00069.25 ETN99068.1 - 7.8e-21 74.6 0.1 1.7e-20 73.5 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN99068.1 - 1.4e-10 40.9 0.1 2.1e-10 40.4 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETN99068.1 - 0.00022 20.6 0.0 0.00038 19.9 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Herpes_TAF50 PF03326.13 ETN99069.1 - 0.022 13.4 0.3 0.025 13.2 0.3 1.1 1 0 0 1 1 1 0 Herpesvirus transcription activation factor (transactivator) zf-TRAF PF02176.18 ETN99070.1 - 2e-05 25.2 2.4 4.7e-05 24.0 1.2 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger Kelch_4 PF13418.6 ETN99073.1 - 3.5e-07 30.1 0.0 1e-05 25.4 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN99073.1 - 5.1e-07 29.4 0.4 0.00024 21.0 0.3 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETN99073.1 - 1.4e-06 27.8 0.2 1.3e-05 24.6 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN99073.1 - 4.9e-05 23.5 0.3 0.037 14.3 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETN99073.1 - 0.07 13.5 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN99073.1 - 0.096 12.7 0.4 1.6 8.8 0.7 2.4 2 0 0 2 2 2 0 Kelch motif TatD_DNase PF01026.21 ETN99074.1 - 4.5e-25 88.5 0.0 4.9e-25 88.4 0.0 1.1 1 0 0 1 1 1 1 TatD related DNase ART PF01129.18 ETN99075.1 - 0.001 18.4 0.2 0.0045 16.3 0.1 1.9 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase E1_UFD PF09358.10 ETN99075.1 - 0.0028 18.3 0.0 0.0097 16.6 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin fold domain WD40 PF00400.32 ETN99076.1 - 0.011 16.6 2.5 0.076 13.9 1.2 2.9 2 2 0 2 2 2 0 WD domain, G-beta repeat Mucin15 PF15672.5 ETN99076.1 - 0.13 11.8 0.7 0.17 11.3 0.7 1.1 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 BRCT_assoc PF12820.7 ETN99076.1 - 0.13 12.0 4.8 0.2 11.5 4.8 1.3 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT OmpH PF03938.14 ETN99076.1 - 1.1 9.6 11.9 1.1 9.6 9.2 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) WD40 PF00400.32 ETN99077.1 - 2.7e-25 88.1 22.0 7.6e-07 29.7 1.8 5.3 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99077.1 - 8.9e-09 35.5 2.1 0.011 16.0 0.1 3.8 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99077.1 - 1.5e-08 33.8 2.4 0.02 13.6 0.1 3.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF1264 PF06884.11 ETN99077.1 - 0.035 13.7 0.8 15 5.1 0.0 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF1264) PSI PF01437.25 ETN99077.1 - 0.084 13.4 5.3 0.12 12.9 3.8 2.1 2 1 0 2 2 2 0 Plexin repeat DUF3902 PF13042.6 ETN99077.1 - 0.96 9.0 2.5 22 4.6 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3902) zf-TRAF PF02176.18 ETN99078.1 - 1.3e-07 32.1 6.1 3.5e-07 30.8 6.1 1.8 1 0 0 1 1 1 1 TRAF-type zinc finger AviRa PF11599.8 ETN99078.1 - 0.15 11.5 3.6 0.26 10.7 3.6 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa HMMR_N PF15905.5 ETN99078.1 - 6.1 6.2 32.9 0.025 14.1 19.0 2.4 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF3102 PF11300.8 ETN99080.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3102) TPR_19 PF14559.6 ETN99082.1 - 0.00013 22.4 0.5 0.0012 19.3 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99082.1 - 0.0012 18.5 1.1 0.051 13.4 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETN99082.1 - 0.0014 18.9 1.0 0.48 10.7 1.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99082.1 - 0.014 15.4 9.1 0.072 13.2 2.3 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Trypan_PARP PF05887.11 ETN99082.1 - 0.13 12.2 19.4 0.27 11.2 19.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TPR_6 PF13174.6 ETN99082.1 - 0.21 12.3 2.5 2.4e+02 2.7 0.0 4.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99082.1 - 0.29 12.0 4.9 0.9 10.5 0.1 4.0 3 1 2 5 5 5 0 Tetratricopeptide repeat UPF0029 PF01205.19 ETN99084.1 - 1.2e-32 112.3 0.1 2.8e-32 111.2 0.1 1.7 1 0 0 1 1 1 1 Uncharacterized protein family UPF0029 RWD PF05773.22 ETN99084.1 - 8.9e-09 35.7 1.2 2.6e-08 34.1 1.2 1.8 1 0 0 1 1 1 1 RWD domain DUF1905 PF08922.11 ETN99085.1 - 0.085 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1905) T_Ag_DNA_bind PF02217.16 ETN99085.1 - 0.11 13.1 0.0 0.15 12.7 0.0 1.3 1 1 0 1 1 1 0 Origin of replication binding protein Chorein_N PF12624.7 ETN99085.1 - 0.28 11.3 4.4 0.55 10.4 4.4 1.5 1 1 0 1 1 1 0 N-terminal region of Chorein or VPS13 PPL5 PF18168.1 ETN99086.1 - 4.2 6.6 9.3 5.7 6.1 9.3 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF1041 PF06292.17 ETN99086.1 - 8.8 6.8 10.7 29 5.1 10.7 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1041) N6_N4_Mtase PF01555.18 ETN99086.1 - 9.3 5.9 19.9 11 5.6 19.0 1.6 1 1 1 2 2 2 0 DNA methylase DUF4337 PF14235.6 ETN99086.1 - 9.8 6.3 14.4 8.3 6.5 13.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) SK_channel PF03530.14 ETN99087.1 - 0.064 13.3 0.1 0.1 12.6 0.1 1.3 1 0 0 1 1 1 0 Calcium-activated SK potassium channel Cys_rich_VLP PF14194.6 ETN99088.1 - 0.01 15.9 0.8 0.023 14.8 0.8 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP FERM_N_2 PF18038.1 ETN99089.1 - 0.06 14.2 2.8 0.079 13.8 0.1 2.2 1 1 0 2 2 2 0 FERM N-terminal domain Peptidase_M28 PF04389.17 ETN99089.1 - 0.47 10.1 2.7 0.53 9.9 2.7 1.1 1 0 0 1 1 1 0 Peptidase family M28 DDHD PF02862.17 ETN99091.1 - 0.19 11.9 4.1 0.22 11.7 4.1 1.2 1 0 0 1 1 1 0 DDHD domain Zip PF02535.22 ETN99091.1 - 2.4 7.3 4.5 3 7.0 4.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETN99091.1 - 3.8 6.2 11.7 5.5 5.6 11.7 1.2 1 0 0 1 1 1 0 Presenilin TPR_12 PF13424.6 ETN99095.1 - 4.3e-15 55.8 0.9 6.9e-15 55.1 0.9 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99095.1 - 6.3e-10 38.6 0.3 0.00022 21.0 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99095.1 - 5.6e-08 32.3 0.3 0.0046 16.9 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99095.1 - 1.1e-07 31.3 8.5 0.00049 19.8 0.4 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99095.1 - 0.00061 19.8 16.3 0.004 17.2 0.2 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99095.1 - 0.18 12.0 4.5 0.3 11.3 0.4 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat COX5A PF02284.16 ETN99098.1 - 0.039 13.9 1.4 0.075 13.0 1.4 1.6 1 1 0 1 1 1 0 Cytochrome c oxidase subunit Va DUF1870 PF08965.10 ETN99099.1 - 0.12 12.5 0.0 0.15 12.1 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1870) zf-CW PF07496.15 ETN99099.1 - 1.8 8.7 5.6 0.73 9.9 0.9 2.4 2 0 0 2 2 2 0 CW-type Zinc Finger TPR_12 PF13424.6 ETN99100.1 - 1.6e-31 108.4 18.3 7.1e-11 42.2 0.1 3.9 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99100.1 - 9.2e-15 53.8 10.0 2.2e-07 30.4 0.2 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99100.1 - 9.5e-15 53.9 2.8 1.4e-07 31.1 0.0 5.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99100.1 - 4.2e-11 42.1 8.5 0.00027 20.8 0.1 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99100.1 - 2.8e-10 39.5 1.9 0.0021 17.9 0.0 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99100.1 - 1.2e-09 37.6 6.8 0.00036 20.5 0.2 4.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN99100.1 - 0.0018 18.8 0.1 1.2 9.9 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99100.1 - 0.005 16.5 12.0 1.1 9.0 0.0 5.1 5 1 1 6 6 6 3 TPR repeat TPR_14 PF13428.6 ETN99100.1 - 0.028 15.2 0.0 16 6.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETN99100.1 - 0.057 13.2 9.5 1.9 8.3 0.5 3.7 1 1 3 4 4 4 0 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETN99100.1 - 0.09 12.5 2.4 18 5.0 0.1 3.4 2 1 0 3 3 3 0 26S proteasome subunit RPN7 TPR_15 PF13429.6 ETN99100.1 - 0.093 11.9 0.0 7.6 5.7 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99100.1 - 0.11 12.9 0.5 44 4.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99100.1 - 0.24 11.7 4.3 0.087 13.1 1.0 2.1 2 1 0 2 2 1 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ETN99100.1 - 0.34 11.3 5.1 12 6.4 0.1 4.4 5 0 0 5 5 5 0 PPR repeat WD40 PF00400.32 ETN99101.1 - 1.9e-65 215.2 18.2 1.2e-09 38.6 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99101.1 - 4.3e-23 81.4 7.5 0.0024 18.1 0.0 6.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99101.1 - 3.9e-13 49.1 3.4 0.17 10.8 0.0 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN99101.1 - 6.9e-09 35.5 4.9 0.00066 19.1 0.2 3.7 2 1 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETN99101.1 - 5e-08 32.1 4.0 0.83 8.2 0.0 4.9 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETN99101.1 - 1e-05 24.3 0.7 0.0064 15.1 0.1 2.9 1 1 3 4 4 4 4 Cytochrome D1 heme domain PD40 PF07676.12 ETN99101.1 - 4.9e-05 23.2 4.2 27 4.8 0.0 6.3 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ETN99101.1 - 0.0029 17.4 0.0 0.054 13.2 0.0 2.6 2 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain DUF5570 PF17731.1 ETN99101.1 - 0.0033 17.5 1.5 22 5.2 0.0 4.9 2 1 3 5 5 5 0 Family of unknown function (DUF5570) PA14 PF07691.12 ETN99101.1 - 0.037 13.8 0.4 7.8 6.3 0.0 2.6 2 1 1 3 3 3 0 PA14 domain DPPIV_N PF00930.21 ETN99101.1 - 0.039 12.7 0.3 23 3.6 0.0 3.9 2 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF727 PF05303.12 ETN99101.1 - 0.043 13.9 0.4 2.4 8.2 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF727) DUF1513 PF07433.11 ETN99101.1 - 0.2 10.7 0.2 19 4.2 0.0 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETN99101.1 - 2.8 7.7 6.5 4 7.2 0.0 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETN99102.1 - 1.1e-27 95.7 27.6 4.1e-06 27.4 1.7 6.3 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99102.1 - 5.6e-08 33.0 2.7 0.1 12.9 0.2 4.8 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99102.1 - 2.1e-07 30.0 4.1 0.033 12.9 2.4 3.9 2 1 2 4 4 4 4 Nucleoporin Nup120/160 Yos1 PF08571.10 ETN99103.1 - 0.065 13.5 0.1 0.13 12.6 0.1 1.4 1 0 0 1 1 1 0 Yos1-like NACHT PF05729.12 ETN99103.1 - 0.13 12.1 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 NACHT domain STI1 PF17830.1 ETN99103.1 - 0.14 12.1 0.9 3.5 7.6 0.0 3.1 3 1 0 3 3 3 0 STI1 domain Ank_4 PF13637.6 ETN99106.1 - 1.3e-07 32.1 0.0 5e-05 23.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETN99106.1 - 1.5e-07 31.9 0.0 2.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETN99106.1 - 7.1e-07 29.1 0.0 0.0077 16.7 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETN99106.1 - 0.00088 19.6 0.1 0.0046 17.4 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETN99106.1 - 0.02 15.2 0.0 1.4 9.4 0.0 2.6 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Apis_Csd PF11671.8 ETN99107.1 - 0.0011 19.1 4.9 0.0014 18.7 4.9 1.1 1 0 0 1 1 1 1 Complementary sex determiner protein FAM176 PF14851.6 ETN99107.1 - 0.087 12.5 5.3 0.11 12.1 5.3 1.3 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 ETN99107.1 - 0.16 11.7 15.4 0.2 11.4 15.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Connexin PF00029.19 ETN99107.1 - 0.24 11.2 5.7 0.24 11.1 5.7 1.1 1 0 0 1 1 1 0 Connexin NPR3 PF03666.13 ETN99107.1 - 0.45 9.2 10.2 0.49 9.1 10.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PIEZO PF15917.5 ETN99107.1 - 0.5 9.8 12.4 0.54 9.7 12.4 1.1 1 0 0 1 1 1 0 Piezo PBP1_TM PF14812.6 ETN99107.1 - 0.69 10.3 14.6 1.2 9.6 14.6 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Presenilin PF01080.17 ETN99107.1 - 1.1 8.0 4.5 1.1 8.0 4.5 1.1 1 0 0 1 1 1 0 Presenilin Folate_carrier PF01770.18 ETN99107.1 - 1.5 7.5 3.4 1.6 7.4 3.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier TFB6 PF17110.5 ETN99107.1 - 3.7 7.3 7.2 4.8 6.9 7.2 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PPL5 PF18168.1 ETN99107.1 - 4 6.6 8.9 4.2 6.6 8.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Sec62 PF03839.16 ETN99107.1 - 4.3 6.8 12.5 4.6 6.7 12.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 V_ATPase_I PF01496.19 ETN99107.1 - 4.4 5.1 8.2 4.6 5.0 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NARP1 PF12569.8 ETN99107.1 - 9.8 5.0 15.0 9.4 5.0 15.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Syntaxin-6_N PF09177.11 ETN99109.1 - 0.52 10.9 5.8 9 6.9 0.2 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HSCB_C PF07743.13 ETN99109.1 - 1.4 9.5 6.5 0.6 10.6 0.3 2.7 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain TPR_8 PF13181.6 ETN99111.1 - 2.7e-06 27.2 0.7 3e-05 23.9 0.1 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99111.1 - 0.00016 21.5 0.1 0.15 12.2 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETN99111.1 - 0.00037 20.7 0.1 0.06 13.6 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99111.1 - 0.0006 19.5 0.2 0.31 11.0 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99111.1 - 0.0068 16.1 0.1 0.66 9.7 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_19 PF14559.6 ETN99111.1 - 0.013 16.0 0.0 0.027 15.0 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99111.1 - 0.02 14.7 0.3 0.68 9.9 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat CNDH2_M PF16869.5 ETN99111.1 - 0.026 15.2 8.6 0.026 15.2 8.6 2.1 2 0 0 2 2 1 0 PF16858 TPR_14 PF13428.6 ETN99111.1 - 0.03 15.2 0.0 0.52 11.3 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99111.1 - 0.069 13.2 0.0 0.56 10.4 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat eIF-3c_N PF05470.12 ETN99111.1 - 0.18 10.1 12.8 0.2 9.9 12.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Hid1 PF12722.7 ETN99111.1 - 1.3 7.0 7.8 1.5 6.8 7.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SURF2 PF05477.11 ETN99111.1 - 3 7.5 18.5 1.1 8.9 15.9 1.6 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Proteasome PF00227.26 ETN99112.1 - 0.15 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Proteasome subunit DUF2115 PF09888.9 ETN99116.1 - 0.61 10.6 4.8 0.59 10.6 3.7 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) WD40 PF00400.32 ETN99117.1 - 3.1e-22 78.5 0.2 4.2e-07 30.5 0.0 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99117.1 - 6.5e-11 42.4 0.1 0.00079 19.7 0.0 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99117.1 - 2.5e-10 39.8 0.0 0.0017 17.4 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN99117.1 - 1.1e-05 24.9 0.1 5.9e-05 22.5 0.1 1.8 1 1 1 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETN99117.1 - 7e-05 22.8 0.1 0.0001 22.3 0.1 1.3 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETN99117.1 - 0.00014 20.6 0.4 0.34 9.5 0.0 2.5 1 1 2 3 3 3 2 Nucleoporin Nup120/160 VID27 PF08553.10 ETN99117.1 - 0.0041 16.2 0.1 0.013 14.6 0.0 1.6 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ETN99117.1 - 0.0094 14.5 0.1 0.024 13.2 0.0 1.5 1 1 0 1 1 1 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETN99117.1 - 0.013 14.3 0.2 0.65 8.7 0.3 2.2 1 1 1 2 2 2 0 Nup133 N terminal like Nbas_N PF15492.6 ETN99117.1 - 0.021 14.2 0.1 0.46 9.8 0.0 2.4 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETN99117.1 - 0.021 14.7 0.0 1.5 8.9 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Lipocalin_4 PF13648.6 ETN99117.1 - 0.063 14.3 0.4 0.12 13.4 0.4 1.6 1 1 0 1 1 1 0 Lipocalin-like domain Proteasome_A_N PF10584.9 ETN99117.1 - 1 9.1 2.9 30 4.4 0.1 3.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Elicitin PF00964.17 ETN99118.1 - 0.065 13.3 0.9 0.11 12.6 0.9 1.3 1 0 0 1 1 1 0 Elicitin V-set_2 PF15910.5 ETN99118.1 - 0.086 12.9 1.6 0.15 12.1 1.6 1.4 1 0 0 1 1 1 0 ICOS V-set domain Baculo_p24 PF05073.12 ETN99118.1 - 0.16 11.7 4.0 0.25 11.1 4.0 1.2 1 0 0 1 1 1 0 Baculovirus P24 capsid protein Gal_Lectin PF02140.18 ETN99118.1 - 0.17 12.4 2.3 0.25 11.8 2.0 1.5 1 1 0 1 1 1 0 Galactose binding lectin domain Exonuc_VII_L PF02601.15 ETN99118.1 - 3.2 7.2 8.2 3.3 7.2 8.1 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit TH1 PF04858.13 ETN99119.1 - 8.1e-12 44.6 3.8 1.1e-11 44.1 3.8 1.1 1 0 0 1 1 1 1 TH1 protein PI_PP_C PF18365.1 ETN99120.1 - 0.014 15.4 2.1 0.049 13.6 0.1 2.8 3 0 0 3 3 3 0 Phosphoinositide phosphatase C-terminal domain EIF_2_alpha PF07541.12 ETN99120.1 - 0.041 14.0 6.7 0.072 13.2 0.2 3.3 3 1 0 3 3 3 0 Eukaryotic translation initiation factor 2 alpha subunit PX PF00787.24 ETN99120.1 - 0.049 13.6 0.3 0.15 12.0 0.1 1.9 2 0 0 2 2 2 0 PX domain YkyA PF10368.9 ETN99120.1 - 0.052 13.2 11.5 0.5 10.0 0.7 2.8 2 1 0 2 2 2 0 Putative cell-wall binding lipoprotein Porphobil_deam PF01379.20 ETN99120.1 - 0.072 12.6 0.7 1.4 8.3 0.1 2.2 2 0 0 2 2 2 0 Porphobilinogen deaminase, dipyromethane cofactor binding domain Csm2_III-A PF03750.13 ETN99120.1 - 7.5 7.4 10.0 0.47 11.3 0.3 3.1 3 1 0 3 3 3 0 Csm2 Type III-A DUF5344 PF17279.2 ETN99120.1 - 8.9 7.0 10.0 1.6 9.3 0.6 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) E1-E2_ATPase PF00122.20 ETN99121.1 - 6.3e-07 29.1 1.0 6.7e-07 29.0 0.1 1.5 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase PF00702.26 ETN99121.1 - 0.022 15.1 0.2 0.03 14.6 0.2 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase GPDPase_memb PF10110.9 ETN99121.1 - 0.071 11.9 0.1 0.096 11.5 0.1 1.1 1 0 0 1 1 1 0 Membrane domain of glycerophosphoryl diester phosphodiesterase Kelch_6 PF13964.6 ETN99123.1 - 6.4e-09 35.8 2.4 0.00024 21.3 0.1 4.5 5 1 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETN99123.1 - 6.3e-08 32.1 0.2 7.2e-05 22.3 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETN99123.1 - 4.1e-07 29.9 0.1 1.2e-05 25.2 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETN99123.1 - 9.7e-06 25.7 0.2 0.00057 20.1 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN99123.1 - 0.0014 18.6 0.1 0.19 11.8 0.1 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETN99123.1 - 0.0014 18.5 0.5 0.06 13.3 0.3 3.4 4 0 0 4 4 4 1 Kelch motif CALCOCO1 PF07888.11 ETN99124.1 - 0.00063 18.7 0.3 0.00063 18.7 0.3 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.8 ETN99124.1 - 0.0018 18.5 5.8 0.0041 17.3 1.8 2.1 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding Gp58 PF07902.11 ETN99124.1 - 0.002 16.5 0.5 0.0021 16.4 0.5 1.2 1 0 0 1 1 1 1 gp58-like protein DUF16 PF01519.16 ETN99124.1 - 0.0051 17.3 1.0 0.0051 17.3 1.0 1.5 2 0 0 2 2 2 1 Protein of unknown function DUF16 ATG16 PF08614.11 ETN99124.1 - 0.0071 16.6 0.6 0.0071 16.6 0.6 1.5 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ETN99124.1 - 0.0083 16.6 0.5 0.011 16.3 0.5 1.1 1 0 0 1 1 1 1 Fez1 Phage_lysis PF03245.13 ETN99124.1 - 0.01 16.0 0.1 0.014 15.5 0.1 1.2 1 0 0 1 1 1 0 Bacteriophage Rz lysis protein V_ATPase_I PF01496.19 ETN99124.1 - 0.014 13.4 1.0 0.016 13.1 1.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UPF0242 PF06785.11 ETN99124.1 - 0.017 15.3 2.7 0.017 15.2 0.9 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HemX PF04375.14 ETN99124.1 - 0.036 13.3 0.2 0.055 12.7 0.2 1.3 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF948 PF06103.11 ETN99124.1 - 0.044 14.0 1.2 0.09 13.0 0.7 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 ETN99124.1 - 0.045 14.3 1.6 0.051 14.1 0.3 1.6 2 0 0 2 2 2 0 Apg6 coiled-coil region YabA PF06156.13 ETN99124.1 - 0.053 14.2 1.8 0.12 13.1 1.7 1.7 1 1 0 1 1 1 0 Initiation control protein YabA SlyX PF04102.12 ETN99124.1 - 0.067 13.8 0.5 0.13 12.9 0.5 1.5 1 0 0 1 1 1 0 SlyX PCNA_C PF02747.15 ETN99124.1 - 0.092 12.9 0.2 0.15 12.3 0.2 1.3 1 1 0 1 1 1 0 Proliferating cell nuclear antigen, C-terminal domain ABC_tran_CTD PF16326.5 ETN99124.1 - 0.1 12.9 1.1 0.18 12.1 0.3 1.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain TMF_DNA_bd PF12329.8 ETN99124.1 - 0.12 12.4 7.8 0.16 12.0 3.4 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DMPK_coil PF08826.10 ETN99124.1 - 0.13 12.4 1.3 0.34 11.0 1.3 1.8 1 1 0 1 1 1 0 DMPK coiled coil domain like SSXRD PF09514.10 ETN99124.1 - 0.13 11.8 0.5 4.2 7.0 0.0 2.8 3 0 0 3 3 3 0 SSXRD motif Laminin_II PF06009.12 ETN99124.1 - 0.19 11.8 4.3 0.073 13.1 1.6 1.6 2 0 0 2 2 2 0 Laminin Domain II Spc7 PF08317.11 ETN99124.1 - 0.2 10.5 4.5 0.32 9.8 4.5 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Fib_alpha PF08702.10 ETN99124.1 - 0.22 11.7 6.8 0.09 13.0 2.2 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Tup_N PF08581.10 ETN99124.1 - 0.25 11.7 5.3 4.4 7.7 0.5 3.1 2 1 1 3 3 3 0 Tup N-terminal Spectrin PF00435.21 ETN99124.1 - 0.27 11.8 2.3 0.51 10.9 1.0 1.8 1 1 0 2 2 2 0 Spectrin repeat DUF724 PF05266.14 ETN99124.1 - 0.44 10.4 3.2 0.6 9.9 1.7 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF724) ZapB PF06005.12 ETN99124.1 - 0.61 10.6 8.9 0.3 11.5 5.7 2.0 2 1 0 2 2 1 0 Cell division protein ZapB Lge1 PF11488.8 ETN99124.1 - 0.73 10.1 5.0 9.1 6.6 0.9 3.2 2 2 2 4 4 4 0 Transcriptional regulatory protein LGE1 Snapin_Pallidin PF14712.6 ETN99124.1 - 0.75 10.3 4.8 0.34 11.4 2.0 1.9 2 0 0 2 2 2 0 Snapin/Pallidin DivIC PF04977.15 ETN99124.1 - 1.8 8.4 6.4 0.49 10.2 1.0 2.4 2 1 1 3 3 3 0 Septum formation initiator DASH_Dad4 PF08650.10 ETN99124.1 - 3.1 7.8 9.6 1.5 8.9 0.9 3.0 2 1 1 3 3 3 0 DASH complex subunit Dad4 DUF4094 PF13334.6 ETN99125.1 - 0.055 13.9 12.6 0.039 14.4 6.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) FAM76 PF16046.5 ETN99125.1 - 0.079 12.3 15.1 0.013 14.9 10.9 1.6 2 0 0 2 2 2 0 FAM76 protein DUF3573 PF12097.8 ETN99125.1 - 7.2 5.3 7.0 0.5 9.1 1.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3573) HU-CCDC81_bac_2 PF18175.1 ETN99127.1 - 0.12 12.3 2.3 0.81 9.6 0.1 2.7 3 0 0 3 3 3 0 CCDC81-like prokaryotic HU domain 2 Cpn60_TCP1 PF00118.24 ETN99128.1 - 2.3e-16 59.5 0.0 2.7e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family WD40 PF00400.32 ETN99131.1 - 3.6e-163 524.5 55.9 1.6e-11 44.6 0.1 15.4 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99131.1 - 8.7e-80 263.1 9.1 5e-05 23.5 0.1 15.2 1 1 14 15 15 15 15 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99131.1 - 3.7e-35 121.7 1.2 0.00027 20.4 0.0 9.9 4 2 6 10 10 10 10 WD40-like domain Ge1_WD40 PF16529.5 ETN99131.1 - 1.4e-20 73.6 0.6 1.4 7.8 0.0 12.9 2 2 12 14 14 14 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN99131.1 - 8.5e-16 57.4 19.7 38 4.4 0.1 14.5 15 0 0 15 15 15 0 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETN99131.1 - 7.9e-12 44.3 0.0 2.6 6.3 0.0 9.7 2 1 6 11 11 11 3 WD repeat-containing and planar cell polarity effector protein Fritz FCP1_C PF09309.10 ETN99131.1 - 5e-09 36.4 0.0 16 5.2 0.0 9.5 3 2 9 12 12 12 0 FCP1, C-terminal Cytochrom_D1 PF02239.16 ETN99131.1 - 2e-08 33.2 8.6 0.25 9.8 0.0 6.4 1 1 3 6 6 6 4 Cytochrome D1 heme domain PQQ PF01011.21 ETN99131.1 - 2.3e-08 33.6 0.0 11 6.1 0.0 9.5 11 0 0 11 11 11 1 PQQ enzyme repeat AMIN PF11741.8 ETN99131.1 - 1.2e-05 25.4 4.2 0.088 12.9 0.1 6.5 5 1 0 7 7 7 1 AMIN domain Gmad1 PF10647.9 ETN99131.1 - 6.4e-05 22.8 4.9 1.6 8.4 0.0 6.2 5 2 1 6 6 6 2 Lipoprotein LpqB beta-propeller domain DUF5570 PF17731.1 ETN99131.1 - 0.0051 16.9 33.9 7.2 6.7 0.2 12.1 1 1 12 14 14 14 1 Family of unknown function (DUF5570) DUF2218 PF09981.9 ETN99131.1 - 0.0067 16.8 0.0 20 5.6 0.0 5.5 6 2 2 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2218) DpaA_N PF16924.5 ETN99131.1 - 0.019 15.1 0.0 37 4.5 0.0 5.5 5 2 1 6 6 6 0 Dipicolinate synthase subunit A N-terminal domain Proteasome_A_N PF10584.9 ETN99131.1 - 0.066 12.9 38.6 1.5e+02 2.1 0.0 14.4 15 0 0 15 15 15 0 Proteasome subunit A N-terminal signature UBA PF00627.31 ETN99132.1 - 2.1e-17 62.7 0.8 3e-06 27.0 0.0 3.9 3 0 0 3 3 3 3 UBA/TS-N domain UBA_4 PF14555.6 ETN99132.1 - 0.00019 21.2 2.6 0.039 13.8 0.0 3.9 4 0 0 4 4 4 1 UBA-like domain DUF789 PF05623.12 ETN99132.1 - 1.4 8.6 11.4 0.25 11.0 7.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF789) TetR_C_1 PF02909.17 ETN99132.1 - 2.6 7.9 7.2 0.26 11.1 0.3 2.7 2 2 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain SID-1_RNA_chan PF13965.6 ETN99132.1 - 3.5 5.9 4.5 5.1 5.4 4.5 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 XRN_M PF17846.1 ETN99132.1 - 6.4 5.6 24.7 0.66 8.9 2.3 2.2 1 1 1 2 2 2 0 Xrn1 helical domain RNase_H PF00075.24 ETN99134.1 - 1.2e-09 38.5 0.0 9.2e-09 35.6 0.0 2.0 1 1 0 1 1 1 1 RNase H zf-RVT PF13966.6 ETN99135.1 - 0.0038 17.9 0.7 0.0048 17.6 0.7 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase HEAT PF02985.22 ETN99136.1 - 5.2e-09 35.6 0.0 0.047 14.0 0.0 4.3 3 1 1 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ETN99136.1 - 1.1e-05 25.7 0.0 0.0055 17.1 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETN99136.1 - 7.1e-05 22.9 1.2 0.035 14.1 0.3 2.5 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETN99136.1 - 0.00011 22.1 1.2 0.16 11.8 0.1 2.4 1 1 1 2 2 2 2 TATA-binding protein interacting (TIP20) DUF2791 PF10923.8 ETN99136.1 - 0.0055 15.6 0.0 0.0067 15.3 0.0 1.1 1 0 0 1 1 1 1 P-loop Domain of unknown function (DUF2791) Ecm29 PF13001.7 ETN99136.1 - 0.01 14.6 0.1 0.012 14.3 0.1 1.0 1 0 0 1 1 1 0 Proteasome stabiliser HEAT_EZ PF13513.6 ETN99136.1 - 0.014 15.8 0.0 4.9 7.8 0.0 2.4 2 0 0 2 2 2 0 HEAT-like repeat TAN PF11640.8 ETN99136.1 - 0.051 13.7 0.2 0.14 12.3 0.2 1.8 1 1 1 2 2 2 0 Telomere-length maintenance and DNA damage repair Spore_III_AB PF09548.10 ETN99136.1 - 0.054 13.6 0.1 0.073 13.2 0.1 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) CCDC-167 PF15188.6 ETN99136.1 - 0.061 13.7 2.6 9.9 6.6 0.1 2.7 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 DUF4197 PF13852.6 ETN99136.1 - 0.077 12.7 0.0 0.51 10.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4197) YojJ PF10372.9 ETN99136.1 - 0.087 12.9 1.9 1.2 9.3 0.3 2.8 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus DUF5105 PF17118.5 ETN99136.1 - 0.092 12.5 0.2 15 5.3 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5105) RTP1_C1 PF10363.9 ETN99136.1 - 0.13 12.4 0.2 6.7 6.9 0.0 2.3 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DNTTIP1_dimer PF18192.1 ETN99136.1 - 0.2 12.0 1.0 17 5.8 0.0 3.2 2 1 2 4 4 4 0 DNTTIP1 dimerisation domain zf-TRAF PF02176.18 ETN99138.1 - 3.8e-06 27.5 3.0 3.8e-06 27.5 3.0 2.3 3 0 0 3 3 3 1 TRAF-type zinc finger DUF2205 PF10224.9 ETN99138.1 - 0.11 12.5 0.0 0.28 11.2 0.0 1.6 1 0 0 1 1 1 0 Short coiled-coil protein zf-RING-like PF08746.11 ETN99138.1 - 1.6 9.1 0.0 1.6 9.1 0.0 3.6 4 1 1 5 5 5 0 RING-like domain zf-TRAF_2 PF15965.5 ETN99138.1 - 1.9 9.0 8.8 0.14 12.7 2.4 2.3 1 1 1 2 2 2 0 TRAF-like zinc-finger PUB PF09409.10 ETN99139.1 - 0.2 11.6 0.6 0.39 10.7 0.4 1.5 1 1 0 1 1 1 0 PUB domain DUF1961 PF09224.11 ETN99140.1 - 0.00013 21.4 41.0 4.3 6.7 0.3 10.6 1 1 12 14 14 14 14 Domain of unknown function (DUF1961) Nop14 PF04147.12 ETN99141.1 - 1.9 6.6 29.3 2.3 6.3 29.3 1.1 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 ETN99141.1 - 8.6 6.0 36.7 11 5.6 36.7 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Na_H_antiport_3 PF07399.11 ETN99143.1 - 0.043 12.7 0.3 0.095 11.6 0.0 1.6 2 0 0 2 2 2 0 Putative Na+/H+ antiporter Atypical_Card PF18461.1 ETN99143.1 - 0.12 12.6 2.4 0.35 11.1 0.5 2.9 2 0 0 2 2 2 0 Atypical caspase recruitment domain WD40 PF00400.32 ETN99145.1 - 4.3e-22 78.0 6.3 2.5e-07 31.3 0.7 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat Kelch_6 PF13964.6 ETN99146.1 - 2.5e-07 30.8 0.2 3.9e-07 30.1 0.2 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 ETN99146.1 - 1.3e-05 24.6 0.5 2e-05 24.1 0.5 1.2 1 0 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 ETN99146.1 - 0.0016 18.7 0.0 0.002 18.3 0.0 1.3 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN99146.1 - 0.0073 16.3 1.5 0.015 15.3 1.5 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 ETN99146.1 - 0.013 15.4 0.2 0.023 14.7 0.2 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.6 ETN99146.1 - 0.013 15.4 0.3 0.024 14.7 0.3 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Hexokinase_2 PF03727.16 ETN99148.1 - 0.071 12.5 0.3 0.24 10.8 0.2 1.7 1 1 1 2 2 2 0 Hexokinase RNase_H PF00075.24 ETN99149.1 - 0.00021 21.5 0.3 0.001 19.3 0.0 2.1 2 0 0 2 2 2 1 RNase H IL22 PF14565.6 ETN99149.1 - 0.019 15.2 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor Dicty_CAD PF05720.12 ETN99149.1 - 0.019 14.9 0.0 0.046 13.7 0.0 1.7 1 1 0 1 1 1 0 Cell-cell adhesion domain YaaC PF14175.6 ETN99151.1 - 0.00015 21.1 1.2 0.00018 20.8 1.2 1.0 1 0 0 1 1 1 1 YaaC-like Protein PPR_3 PF13812.6 ETN99152.1 - 3.4e-12 46.2 3.4 1.7e-06 28.0 0.1 2.7 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETN99152.1 - 2.7e-10 40.3 0.5 2.7e-08 33.9 0.1 2.5 2 0 0 2 2 2 1 PPR repeat family PPR_1 PF12854.7 ETN99152.1 - 6.9e-10 38.5 1.9 3.3e-05 23.5 0.0 3.3 3 0 0 3 3 3 3 PPR repeat ATP13 PF12921.7 ETN99152.1 - 3.2e-05 23.8 0.4 7.2e-05 22.6 0.4 1.6 1 0 0 1 1 1 1 Mitochondrial ATPase expression PPR PF01535.20 ETN99152.1 - 0.00015 21.7 0.6 0.00051 20.1 0.0 2.2 2 0 0 2 2 2 1 PPR repeat PPR_long PF17177.4 ETN99152.1 - 0.013 14.9 0.0 0.026 13.9 0.0 1.6 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP DUF3987 PF13148.6 ETN99152.1 - 0.15 11.0 1.2 0.23 10.4 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) WD40 PF00400.32 ETN99153.1 - 3.1e-29 100.6 2.9 1.5e-09 38.3 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99153.1 - 3.8e-12 46.4 0.0 0.0018 18.5 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99153.1 - 2.8e-07 29.8 0.0 0.044 12.7 0.0 2.9 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETN99153.1 - 4.5e-07 30.0 0.0 5.3e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETN99153.1 - 1.1e-05 25.3 1.4 1.3 9.0 0.0 3.7 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETN99153.1 - 3.8e-05 23.2 0.0 0.002 17.5 0.0 2.0 1 1 1 2 2 2 1 WD40-like domain Proteasome_A_N PF10584.9 ETN99153.1 - 0.0059 16.3 2.3 9.3 6.0 0.0 3.5 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Nup160 PF11715.8 ETN99153.1 - 0.0091 14.7 0.1 0.05 12.2 0.0 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETN99153.1 - 0.14 11.1 0.2 7.8 5.3 0.1 2.1 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain nos_propeller PF18764.1 ETN99153.1 - 0.14 12.1 0.0 48 4.0 0.0 3.0 2 1 1 3 3 3 0 Nitrous oxide reductase propeller repeat NOA36 PF06524.12 ETN99154.1 - 1.4 8.2 9.3 2.5 7.4 9.3 1.4 1 0 0 1 1 1 0 NOA36 protein Vfa1 PF08432.10 ETN99154.1 - 1.9 8.8 7.2 3.2 8.0 7.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 BUD22 PF09073.10 ETN99154.1 - 6.5 6.0 16.6 7.9 5.7 16.6 1.3 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETN99154.1 - 7.3 4.8 12.2 8.5 4.5 12.2 1.1 1 0 0 1 1 1 0 CDC45-like protein ApoC-I PF04691.12 ETN99157.1 - 0.078 12.9 1.1 0.4 10.7 1.1 2.2 1 1 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) TPR_12 PF13424.6 ETN99158.1 - 3.7e-74 245.0 0.3 1.6e-23 82.8 0.0 4.2 2 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99158.1 - 1.5e-64 212.3 0.0 1.4e-11 43.8 0.0 6.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99158.1 - 9.4e-52 169.3 1.0 5.7e-08 32.2 0.0 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99158.1 - 9.3e-47 155.0 31.8 1.9e-09 37.0 0.9 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99158.1 - 5.1e-31 104.3 34.1 2e-06 27.6 0.5 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99158.1 - 4.6e-25 85.7 24.0 7.6e-05 22.5 0.1 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99158.1 - 2.7e-22 77.5 10.7 0.00063 19.9 0.0 7.4 6 1 2 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99158.1 - 6e-15 55.6 0.0 0.0026 18.4 0.0 5.6 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99158.1 - 1.3e-11 44.3 0.0 1.5 9.9 0.0 6.1 4 2 2 6 6 6 2 Tetratricopeptide repeat MIT PF04212.18 ETN99158.1 - 9.8e-11 41.6 20.0 0.048 13.7 0.2 6.1 3 2 3 6 6 6 3 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETN99158.1 - 5.6e-10 38.8 13.3 0.015 15.5 0.1 6.0 6 0 0 6 6 6 2 PPR repeat DUF5113 PF17140.4 ETN99158.1 - 2.9e-08 33.7 11.5 0.46 10.3 0.1 5.7 3 2 3 6 6 6 3 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETN99158.1 - 5.6e-08 32.3 37.3 0.024 14.3 4.2 10.0 5 4 5 10 10 10 3 TPR repeat TPR_6 PF13174.6 ETN99158.1 - 7.3e-08 32.6 1.5 5.5 7.9 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF4810 PF16068.5 ETN99158.1 - 9.2e-06 26.1 5.9 7.6 7.2 0.0 4.5 2 1 0 4 4 4 0 Domain of unknown function (DUF4810) TPR_19 PF14559.6 ETN99158.1 - 2e-05 25.0 0.3 2.9 8.5 0.0 3.9 2 1 3 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99158.1 - 4.8e-05 23.5 8.5 0.28 11.4 0.4 4.3 1 1 4 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 HTH_Bact PF18768.1 ETN99158.1 - 8.5e-05 22.0 6.8 35 4.1 0.1 6.5 6 1 0 6 6 6 0 Helix-turn-helix bacterial domain TPR_MalT PF17874.1 ETN99158.1 - 0.00012 21.5 0.0 0.00083 18.8 0.0 1.8 1 1 1 2 2 2 1 MalT-like TPR region TPR_3 PF07720.12 ETN99158.1 - 0.00014 21.7 23.8 1.3 9.1 0.1 6.2 6 0 0 6 6 6 2 Tetratricopeptide repeat DUF2777 PF10949.8 ETN99158.1 - 0.0004 20.1 1.8 2.5 7.7 0.1 4.1 2 2 3 5 5 5 1 Protein of unknown function (DUF2777) Fis1_TPR_C PF14853.6 ETN99158.1 - 0.0011 18.9 10.7 6.9 6.8 0.2 5.8 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat KH_4 PF13083.6 ETN99158.1 - 0.0015 18.4 0.0 0.67 9.9 0.0 2.9 1 1 1 2 2 2 1 KH domain DUF2977 PF11192.8 ETN99158.1 - 0.0032 17.6 1.5 86 3.4 0.1 5.3 5 1 1 6 6 6 0 Protein of unknown function (DUF2977) Frataxin_Cyay PF01491.16 ETN99158.1 - 0.0081 16.2 2.2 6 7.0 0.0 3.4 1 1 2 3 3 3 0 Frataxin-like domain Thump_like PF18096.1 ETN99158.1 - 0.017 15.0 0.2 88 3.1 0.0 4.5 5 0 0 5 5 5 0 THUMP domain-like YtzH PF14165.6 ETN99158.1 - 0.035 14.5 6.6 34 4.9 0.0 5.3 6 0 0 6 6 6 0 YtzH-like protein RPN7 PF10602.9 ETN99158.1 - 0.06 13.1 5.2 30 4.3 0.0 3.8 1 1 1 3 3 3 0 26S proteasome subunit RPN7 Musclin PF11037.8 ETN99158.1 - 0.13 12.2 0.0 45 4.0 0.0 3.5 4 0 0 4 4 4 0 Insulin-resistance promoting peptide in skeletal muscle TPR_9 PF13371.6 ETN99158.1 - 0.17 12.0 0.0 7.6 6.8 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 ETN99158.1 - 0.95 9.5 6.4 15 5.7 0.3 4.3 2 2 0 3 3 3 0 Protein of unknown function (DUF627) PPR_2 PF13041.6 ETN99158.1 - 1.6 9.0 4.2 46 4.3 0.1 3.9 4 0 0 4 4 4 0 PPR repeat family SepRS_C PF18006.1 ETN99159.1 - 0.062 13.4 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 O-phosphoseryl-tRNA synthetase C-terminal domain DUF4713 PF15831.5 ETN99159.1 - 1.3 9.5 4.8 0.46 11.0 1.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) NUDIX PF00293.28 ETN99160.1 - 0.00015 21.8 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 NUDIX domain zf-Di19 PF05605.12 ETN99160.1 - 0.00063 20.0 5.2 0.18 12.1 0.3 2.6 2 0 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ETN99160.1 - 0.0079 17.0 12.0 0.025 15.4 0.9 3.1 3 0 0 3 3 3 2 C2H2-type zinc finger NUDIX_2 PF13869.6 ETN99160.1 - 0.011 15.3 0.1 0.027 14.0 0.1 1.6 1 0 0 1 1 1 0 Nucleotide hydrolase zf-C2H2 PF00096.26 ETN99160.1 - 0.035 14.5 1.7 0.035 14.5 1.7 3.1 3 0 0 3 3 3 0 Zinc finger, C2H2 type Rad50_zn_hook PF04423.14 ETN99160.1 - 0.058 13.2 0.2 0.18 11.7 0.2 1.8 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2H2_2 PF12756.7 ETN99160.1 - 0.084 13.2 7.3 4 7.8 7.2 2.7 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ETN99160.1 - 2.3 8.9 20.7 1.2 9.8 0.2 4.7 3 1 2 5 5 5 0 Zinc finger C2H2-type, 3 repeats CCDC106 PF15794.5 ETN99160.1 - 6.5 6.4 24.1 1.7 8.3 3.8 3.3 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 106 DUF2985 PF11204.8 ETN99161.1 - 0.57 10.4 6.4 1.5 9.0 6.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2985) Destabilase PF05497.12 ETN99164.1 - 0.0061 16.9 3.4 0.0076 16.6 3.4 1.1 1 0 0 1 1 1 1 Destabilase WD40 PF00400.32 ETN99165.1 - 1.2e-29 101.9 12.9 1e-06 29.3 0.2 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99165.1 - 4.8e-14 52.4 0.1 0.0012 19.1 0.0 4.2 4 0 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99165.1 - 1.4e-11 43.8 0.9 0.0028 16.4 0.1 3.7 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99165.1 - 2.6e-05 23.7 0.8 0.2 10.9 0.1 3.8 2 1 1 3 3 3 2 WD40-like domain DUF851 PF05867.11 ETN99165.1 - 0.00067 19.2 0.0 0.12 11.9 0.0 2.3 1 1 0 2 2 2 2 Protein of unknown function (DUF851) Nucleoporin_N PF08801.11 ETN99165.1 - 0.0017 17.2 1.1 0.57 8.9 0.1 3.1 1 1 2 3 3 3 2 Nup133 N terminal like ABC_transp_aux PF09822.9 ETN99167.1 - 0.0035 16.9 0.0 0.0041 16.6 0.0 1.1 1 0 0 1 1 1 1 ABC-type uncharacterized transport system DUF4350 PF14258.6 ETN99167.1 - 0.036 14.5 0.0 0.067 13.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4350) DDHD PF02862.17 ETN99168.1 - 0.0012 19.0 5.3 0.0012 19.0 5.3 2.2 1 1 1 2 2 2 1 DDHD domain MukF_M PF17192.4 ETN99168.1 - 0.0053 16.5 5.0 0.0053 16.5 5.0 3.7 3 1 0 3 3 3 1 MukF middle domain SUIM_assoc PF16619.5 ETN99168.1 - 0.23 11.6 5.7 1.1 9.4 5.7 2.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Sec23_helical PF04815.15 ETN99168.1 - 0.79 9.6 4.9 1.9 8.4 0.2 3.7 3 1 0 3 3 3 0 Sec23/Sec24 helical domain Sas10_Utp3 PF04000.15 ETN99169.1 - 0.19 12.4 1.9 0.35 11.5 1.9 1.7 1 1 0 1 1 1 0 Sas10/Utp3/C1D family Ank_5 PF13857.6 ETN99170.1 - 0.024 15.0 0.0 0.054 13.8 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) MinC_N PF05209.13 ETN99170.1 - 0.062 13.3 0.2 0.088 12.8 0.2 1.3 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain DUF4219 PF13961.6 ETN99172.1 - 0.39 10.4 2.8 1.2 8.9 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4219) Chordopox_A13L PF05961.11 ETN99173.1 - 0.022 15.0 2.7 0.041 14.1 1.5 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein AHSP PF09236.10 ETN99173.1 - 0.051 14.0 3.2 0.11 13.0 0.4 2.6 2 1 1 3 3 3 0 Alpha-haemoglobin stabilising protein UPF0184 PF03670.13 ETN99173.1 - 0.65 10.4 6.0 0.51 10.8 0.6 2.5 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0184) CTP-dep_RFKase PF01982.16 ETN99174.1 - 0.068 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF120 Copine PF07002.16 ETN99176.1 - 2.2e-09 37.1 0.0 3.4e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Copine ATG_C PF09333.11 ETN99177.1 - 0.011 16.1 1.4 0.016 15.6 1.4 1.2 1 0 0 1 1 1 0 Autophagy-related protein C terminal domain Med3 PF11593.8 ETN99177.1 - 0.078 12.2 12.1 0.082 12.1 12.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FAM199X PF15814.5 ETN99177.1 - 0.16 11.0 4.9 0.22 10.6 4.9 1.1 1 0 0 1 1 1 0 Protein family FAM199X FSA_C PF10479.9 ETN99177.1 - 0.34 9.0 11.5 0.35 8.9 11.5 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TFB6 PF17110.5 ETN99178.1 - 0.0034 17.1 0.5 0.012 15.4 0.2 2.1 2 0 0 2 2 2 1 Subunit 11 of the general transcription factor TFIIH Receptor_2B4 PF11465.8 ETN99179.1 - 0.016 15.4 0.0 0.032 14.4 0.0 1.4 1 0 0 1 1 1 0 Natural killer cell receptor 2B4 ubiquitin PF00240.23 ETN99182.1 - 5.1e-07 29.3 0.5 5.6e-06 26.0 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin family LYRIC PF15686.5 ETN99182.1 - 0.065 12.8 13.7 0.071 12.7 13.7 1.2 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF3398 PF11878.8 ETN99183.1 - 0.0014 19.0 1.5 0.26 11.7 0.5 2.2 1 1 0 2 2 2 2 Domain of unknown function (DUF3398) DUF3164 PF11363.8 ETN99184.1 - 0.01 15.4 0.0 0.011 15.3 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3164) UN_NPL4 PF11543.8 ETN99184.1 - 0.021 15.3 0.0 0.028 14.9 0.0 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 PB1 PF00564.24 ETN99184.1 - 0.044 13.7 0.1 0.063 13.2 0.1 1.3 1 0 0 1 1 1 0 PB1 domain EF-hand_5 PF13202.6 ETN99184.1 - 0.61 9.7 0.0 0.61 9.7 0.0 2.3 2 0 0 2 2 2 0 EF hand WD40 PF00400.32 ETN99186.1 - 0.0011 19.7 0.0 0.028 15.3 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Phage_GP20 PF06810.11 ETN99187.1 - 0.035 13.9 31.3 0.033 14.0 13.6 3.1 3 0 0 3 3 3 0 Phage minor structural protein GP20 CCM2_C PF16545.5 ETN99187.1 - 4 8.0 7.0 3.8 8.1 1.7 3.3 1 1 1 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology DUF5586 PF17824.1 ETN99188.1 - 0.0073 15.5 0.3 0.0081 15.3 0.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5586) PalH PF08733.10 ETN99189.1 - 0.022 13.8 6.1 0.032 13.2 6.1 1.4 1 1 0 1 1 1 0 PalH/RIM21 Choline_sulf_C PF12411.8 ETN99190.1 - 0.027 14.3 0.1 0.052 13.4 0.1 1.5 1 0 0 1 1 1 0 Choline sulfatase enzyme C terminal Laminin_II PF06009.12 ETN99191.1 - 2.4e-05 24.3 2.1 3.6e-05 23.8 2.1 1.2 1 0 0 1 1 1 1 Laminin Domain II Vps5 PF09325.10 ETN99191.1 - 0.00083 19.0 4.2 0.0011 18.6 4.2 1.1 1 0 0 1 1 1 1 Vps5 C terminal like COG2 PF06148.11 ETN99191.1 - 0.0013 18.9 0.6 0.0021 18.2 0.6 1.5 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 SHE3 PF17078.5 ETN99191.1 - 0.0032 17.2 6.2 0.0044 16.8 6.2 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Lipoprotein_2 PF00921.17 ETN99191.1 - 0.0034 17.0 1.4 0.0042 16.7 1.4 1.1 1 0 0 1 1 1 1 Borrelia lipoprotein Fib_alpha PF08702.10 ETN99191.1 - 0.0042 17.3 6.4 0.0058 16.8 6.4 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family DUF948 PF06103.11 ETN99191.1 - 0.006 16.8 3.2 0.012 15.8 2.9 1.6 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) ATPase PF06745.13 ETN99191.1 - 0.0084 15.5 0.5 0.011 15.1 0.5 1.2 1 0 0 1 1 1 1 KaiC BAR_3 PF16746.5 ETN99191.1 - 0.0087 15.8 5.2 0.011 15.4 5.2 1.2 1 0 0 1 1 1 1 BAR domain of APPL family Filo_VP35 PF02097.15 ETN99191.1 - 0.015 14.4 0.6 0.019 14.1 0.6 1.1 1 0 0 1 1 1 0 Filoviridae VP35 Talin_middle PF09141.10 ETN99191.1 - 0.021 14.8 8.0 0.087 12.9 0.9 2.1 1 1 1 2 2 2 0 Talin, middle domain DUF1664 PF07889.12 ETN99191.1 - 0.022 14.8 3.6 0.058 13.4 3.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Tup_N PF08581.10 ETN99191.1 - 0.029 14.7 4.9 0.042 14.2 0.8 2.3 1 1 1 2 2 2 0 Tup N-terminal Allexi_40kDa PF05549.11 ETN99191.1 - 0.038 13.5 1.2 0.045 13.3 1.2 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein PG_binding_4 PF12229.8 ETN99191.1 - 0.046 14.0 3.6 0.078 13.3 0.2 2.0 1 1 1 2 2 2 0 Putative peptidoglycan binding domain TMPIT PF07851.13 ETN99191.1 - 0.078 12.2 2.2 0.094 11.9 2.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein FlaC_arch PF05377.11 ETN99191.1 - 0.1 13.0 7.8 12 6.4 6.8 3.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Vps51 PF08700.11 ETN99191.1 - 0.13 12.4 11.2 3.6 7.7 0.5 3.2 1 1 2 3 3 3 0 Vps51/Vps67 DASH_Dam1 PF08653.10 ETN99191.1 - 0.16 11.8 8.6 4.1 7.3 0.3 3.1 1 1 1 2 2 2 0 DASH complex subunit Dam1 Matrilin_ccoil PF10393.9 ETN99191.1 - 0.16 11.8 1.4 0.62 10.0 0.6 2.3 1 1 1 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF724 PF05266.14 ETN99191.1 - 0.23 11.3 5.4 0.42 10.4 5.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) ALMT PF11744.8 ETN99191.1 - 0.34 9.7 4.1 0.39 9.5 4.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Syntaxin_2 PF14523.6 ETN99191.1 - 0.52 10.7 10.8 16 6.0 10.7 2.2 1 1 0 1 1 1 0 Syntaxin-like protein Spc24 PF08286.11 ETN99191.1 - 0.83 9.9 7.9 4.6 7.5 1.2 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 DASH_Dad1 PF08649.10 ETN99191.1 - 1.2 9.4 5.7 0.35 11.1 0.7 2.3 1 1 1 2 2 2 0 DASH complex subunit Dad1 XhlA PF10779.9 ETN99191.1 - 1.3 9.3 9.8 3.1 8.1 0.8 2.4 1 1 1 2 2 2 0 Haemolysin XhlA Mic1 PF07035.12 ETN99192.1 - 0.04 13.6 0.2 0.21 11.3 0.1 1.9 2 0 0 2 2 2 0 Colon cancer-associated protein Mic1-like tRNA_bind PF01588.20 ETN99193.1 - 7.4e-25 86.9 0.0 1.2e-24 86.2 0.0 1.3 1 0 0 1 1 1 1 Putative tRNA binding domain Peptidase_C14 PF00656.22 ETN99195.1 - 1.3e-12 48.2 0.1 1.7e-12 47.8 0.1 1.0 1 0 0 1 1 1 1 Caspase domain ABC2_membrane_5 PF13346.6 ETN99196.1 - 0.11 12.0 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein KIP1 PF07765.12 ETN99196.1 - 0.8 9.9 5.2 1.4 9.1 5.2 1.4 1 0 0 1 1 1 0 KIP1-like protein SecE PF00584.20 ETN99197.1 - 0.033 14.1 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex TMEM208_SND2 PF05620.11 ETN99197.1 - 0.057 13.2 1.2 0.072 12.9 1.2 1.2 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 WD40 PF00400.32 ETN99199.1 - 2.6e-10 40.7 0.9 1.8e-08 34.9 0.2 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Peptidase_S80 PF07230.11 ETN99199.1 - 0.00073 17.9 0.9 0.00088 17.7 0.9 1.1 1 0 0 1 1 1 1 Bacteriophage T4-like capsid assembly protein (Gp20) ANAPC4_WD40 PF12894.7 ETN99199.1 - 0.02 15.2 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Macoilin PF09726.9 ETN99201.1 - 1.2 7.5 11.3 1.5 7.3 11.3 1.0 1 0 0 1 1 1 0 Macoilin family WD40 PF00400.32 ETN99202.1 - 5.2e-05 23.9 0.6 0.0011 19.7 0.2 2.9 2 2 0 2 2 2 1 WD domain, G-beta repeat DUF4061 PF13270.6 ETN99205.1 - 0.048 14.0 0.1 0.048 14.0 0.1 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4061) ING PF12998.7 ETN99205.1 - 2.7 8.7 7.4 0.38 11.4 0.2 2.7 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding CENP-Q PF13094.6 ETN99205.1 - 4.8 7.4 9.3 11 6.1 6.2 2.6 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit WD40 PF00400.32 ETN99207.1 - 1.4e-18 66.8 14.2 5.6e-05 23.8 0.7 5.3 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99207.1 - 1.1e-07 32.1 0.0 0.73 10.2 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99207.1 - 3e-06 26.2 1.0 2.5 6.6 0.0 4.0 2 1 2 4 4 4 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETN99207.1 - 0.04 14.0 0.5 32 4.6 0.0 3.7 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Gp49 PF05973.14 ETN99208.1 - 0.074 13.2 1.2 0.13 12.4 1.2 1.5 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) WD40 PF00400.32 ETN99209.1 - 5.7e-13 49.1 11.1 6.2e-06 26.9 0.1 4.0 3 1 1 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN99209.1 - 0.00013 20.8 0.2 0.22 10.1 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99209.1 - 0.00065 19.9 0.0 0.018 15.3 0.0 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN99209.1 - 0.0076 15.0 1.8 0.2 10.4 0.6 2.5 1 1 0 2 2 2 2 Nup133 N terminal like UBN_AB PF14075.6 ETN99210.1 - 0.019 14.7 2.7 0.025 14.3 2.5 1.3 1 1 0 1 1 1 0 Ubinuclein conserved middle domain SprA-related PF12118.8 ETN99210.1 - 0.35 10.0 2.8 0.45 9.6 2.8 1.1 1 0 0 1 1 1 0 SprA-related family Tmem26 PF09772.9 ETN99212.1 - 0.15 11.4 0.0 0.25 10.6 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 26 SPX PF03105.19 ETN99212.1 - 1.5 8.7 14.7 1.9 8.3 14.7 1.0 1 0 0 1 1 1 0 SPX domain Ndc1_Nup PF09531.10 ETN99215.1 - 2.5 6.7 7.6 2.7 6.6 7.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3416 PF11896.8 ETN99217.1 - 0.0033 17.8 0.0 0.038 14.3 0.0 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3416) Halogen_Hydrol PF10112.9 ETN99218.1 - 0.0062 16.6 0.5 0.01 15.9 0.5 1.3 1 0 0 1 1 1 1 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF3818 PF12825.7 ETN99219.1 - 0.16 10.9 3.0 0.19 10.7 3.0 1.0 1 0 0 1 1 1 0 Domain of unknown function in PX-proteins (DUF3818) Presenilin PF01080.17 ETN99219.1 - 2 7.1 5.8 2 7.1 5.8 1.0 1 0 0 1 1 1 0 Presenilin DUF4703 PF15775.5 ETN99219.1 - 2 8.2 5.3 2.6 7.8 5.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4703) DUF874 PF05917.11 ETN99219.1 - 7.1 5.6 16.4 8.8 5.2 16.4 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) UPF0203 PF05254.12 ETN99220.1 - 0.0097 16.1 7.7 0.59 10.4 1.6 2.4 1 1 0 2 2 2 2 Uncharacterised protein family (UPF0203) UCMA PF17085.5 ETN99220.1 - 0.017 15.1 0.4 0.063 13.3 0.1 1.9 2 0 0 2 2 2 0 Unique cartilage matrix associated protein UCR_hinge PF02320.16 ETN99220.1 - 0.034 14.3 4.7 0.29 11.4 4.7 2.2 1 1 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein BTB_2 PF02214.22 ETN99220.1 - 0.051 13.9 2.9 0.73 10.2 0.2 2.6 2 1 0 2 2 2 0 BTB/POZ domain WW PF00397.26 ETN99220.1 - 0.13 12.4 1.6 0.14 12.2 0.2 1.8 2 0 0 2 2 2 0 WW domain COX6B PF02297.17 ETN99220.1 - 1.2 9.4 6.7 0.18 12.1 1.8 2.1 1 1 1 2 2 2 0 Cytochrome oxidase c subunit VIb TPR_8 PF13181.6 ETN99221.1 - 1.9e-05 24.5 0.2 3.9e-05 23.5 0.2 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99221.1 - 8.1e-05 22.3 0.2 0.00012 21.7 0.2 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETN99221.1 - 0.00026 21.2 0.0 0.00038 20.7 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99221.1 - 0.0008 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99221.1 - 0.029 14.5 0.0 0.051 13.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99224.1 - 0.0012 18.5 0.1 0.0012 18.5 0.1 1.7 2 0 0 2 2 2 1 TPR repeat BCDHK_Adom3 PF10436.9 ETN99224.1 - 0.028 14.2 2.6 0.11 12.4 1.9 1.9 1 1 1 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase LETM1 PF07766.13 ETN99224.1 - 0.035 13.4 2.5 0.042 13.2 2.5 1.1 1 0 0 1 1 1 0 LETM1-like protein Hist_deacetyl PF00850.19 ETN99224.1 - 0.16 11.4 1.2 0.18 11.2 1.2 1.1 1 0 0 1 1 1 0 Histone deacetylase domain DUF4175 PF13779.6 ETN99224.1 - 0.62 7.9 9.1 0.68 7.8 9.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) VIT1 PF01988.19 ETN99224.1 - 2.5 7.9 3.4 2.9 7.7 3.4 1.1 1 0 0 1 1 1 0 VIT family GBP_C PF02841.14 ETN99224.1 - 3.8 6.8 13.8 4.3 6.7 13.8 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF2207 PF09972.9 ETN99225.1 - 2.3 6.9 9.5 0.36 9.5 1.0 2.3 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) RPW8 PF05659.11 ETN99225.1 - 4.3 7.0 8.6 0.19 11.4 0.5 2.5 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 WD40 PF00400.32 ETN99226.1 - 6.1e-06 26.9 6.1 0.00011 22.9 1.1 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETN99226.1 - 0.00025 19.8 1.7 0.00029 19.6 1.0 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99226.1 - 0.0063 16.8 0.4 0.036 14.3 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF2956 PF11169.8 ETN99226.1 - 0.2 11.8 7.5 0.062 13.5 1.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Col_cuticle_N PF01484.17 ETN99226.1 - 0.64 10.1 3.1 0.51 10.4 0.3 2.3 2 1 0 2 2 2 0 Nematode cuticle collagen N-terminal domain YabA PF06156.13 ETN99226.1 - 1.2 9.8 14.1 2.5 8.8 7.6 2.4 2 0 0 2 2 2 0 Initiation control protein YabA Sec20 PF03908.13 ETN99226.1 - 1.8 8.5 10.6 0.47 10.4 5.9 2.2 1 1 2 3 3 3 0 Sec20 ADIP PF11559.8 ETN99226.1 - 2 8.5 20.7 0.52 10.4 10.8 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding BST2 PF16716.5 ETN99226.1 - 8.3 7.1 18.7 1.1 9.9 10.3 2.3 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 ADIP PF11559.8 ETN99228.1 - 0.00031 20.9 3.2 0.00034 20.7 2.1 1.6 1 1 0 1 1 1 1 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 ETN99228.1 - 0.0011 19.3 2.4 0.0014 18.9 2.4 1.4 1 1 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF3450 PF11932.8 ETN99228.1 - 0.0016 17.8 2.9 0.0023 17.3 2.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETN99228.1 - 0.0039 17.2 0.3 0.0062 16.6 0.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETN99228.1 - 0.0059 17.1 2.5 0.0084 16.6 2.2 1.5 1 1 0 1 1 1 1 Apg6 coiled-coil region IES5 PF17335.2 ETN99228.1 - 0.0096 16.2 0.9 0.26 11.6 0.3 2.3 1 1 1 2 2 2 1 Ino80 complex subunit 5 Rac1 PF09632.10 ETN99228.1 - 0.012 14.9 1.3 0.015 14.5 1.3 1.2 1 0 0 1 1 1 0 Rac1-binding domain DHR10 PF18595.1 ETN99228.1 - 0.012 15.6 2.7 0.016 15.2 1.9 1.6 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF641 PF04859.12 ETN99228.1 - 0.016 15.5 0.7 0.027 14.8 0.5 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 ETN99228.1 - 0.026 15.0 0.3 0.068 13.6 0.3 1.8 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Atg14 PF10186.9 ETN99228.1 - 0.028 13.5 2.0 0.034 13.3 2.0 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MbeD_MobD PF04899.12 ETN99228.1 - 0.054 13.6 2.9 0.18 11.9 1.7 2.3 1 1 1 2 2 2 0 MbeD/MobD like FlaC_arch PF05377.11 ETN99228.1 - 0.081 13.3 0.2 27 5.2 0.0 2.9 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) ZnuA PF01297.17 ETN99228.1 - 0.086 12.2 1.8 0.11 11.9 1.8 1.1 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic LPP PF04728.13 ETN99228.1 - 0.087 13.2 1.8 0.3 11.5 0.3 2.6 1 1 1 2 2 2 0 Lipoprotein leucine-zipper HrpB7 PF09486.10 ETN99228.1 - 0.093 13.1 3.1 0.43 11.0 3.1 1.9 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) V-SNARE_C PF12352.8 ETN99228.1 - 0.11 12.8 0.5 6.9 7.0 0.4 2.4 1 1 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Acetyltransf_11 PF13720.6 ETN99228.1 - 0.18 12.3 1.7 14 6.2 0.2 2.7 2 1 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 GAT PF03127.14 ETN99228.1 - 0.2 12.0 2.5 0.15 12.4 0.5 2.0 2 1 0 2 2 2 0 GAT domain DUF4407 PF14362.6 ETN99228.1 - 0.2 11.0 4.4 0.23 10.8 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Bap31_Bap29_C PF18035.1 ETN99228.1 - 0.28 11.2 5.8 0.083 12.9 2.4 1.9 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain YlqD PF11068.8 ETN99228.1 - 0.35 11.2 4.4 0.57 10.5 4.4 1.4 1 0 0 1 1 1 0 YlqD protein TMF_DNA_bd PF12329.8 ETN99228.1 - 0.37 10.8 3.6 0.24 11.4 0.5 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 ETN99228.1 - 0.47 10.3 6.4 0.12 12.1 1.7 2.4 2 1 2 4 4 4 0 Septum formation initiator SlyX PF04102.12 ETN99228.1 - 1.8 9.2 4.9 2.3 8.9 1.8 2.4 1 1 1 2 2 2 0 SlyX NACHT PF05729.12 ETN99229.1 - 4.3e-08 33.3 0.0 6.7e-08 32.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain CsgG PF03783.14 ETN99229.1 - 0.1 11.8 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Curli production assembly/transport component CsgG SDA1 PF05285.12 ETN99231.1 - 0.0078 15.7 9.6 0.016 14.7 9.6 1.6 1 0 0 1 1 1 1 SDA1 Zip PF02535.22 ETN99231.1 - 0.41 9.8 4.9 1.1 8.4 4.9 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4820 PF16091.5 ETN99231.1 - 4.9 6.5 9.0 20 4.5 6.6 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) TSP_NTD PF17804.1 ETN99233.1 - 0.021 15.1 3.4 0.023 15.0 3.4 1.1 1 0 0 1 1 1 0 Tail specific protease N-terminal domain DUF4337 PF14235.6 ETN99233.1 - 0.03 14.4 0.5 0.033 14.3 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) PPR PF01535.20 ETN99234.1 - 3.1e-05 23.9 0.9 0.14 12.4 0.1 3.3 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.6 ETN99234.1 - 4e-05 23.7 3.2 0.018 15.2 0.1 3.2 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 ETN99234.1 - 0.001 19.1 0.2 0.23 11.5 0.1 3.0 2 1 1 3 3 3 1 Pentatricopeptide repeat domain zf-TRAF PF02176.18 ETN99235.1 - 7.6e-08 32.9 2.5 7.6e-08 32.9 2.5 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger Peroxin-13_N PF04088.13 ETN99236.1 - 0.034 14.4 1.1 1.1 9.5 0.2 3.0 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Orf78 PF06024.12 ETN99236.1 - 0.34 11.2 4.3 12 6.3 0.2 2.5 2 0 0 2 2 2 0 Orf78 (ac78) NPR1_interact PF15699.5 ETN99236.1 - 1 10.0 0.0 1 10.0 0.0 3.1 3 0 0 3 3 3 0 NPR1 interacting Corazonin PF17308.2 ETN99236.1 - 8.3 6.8 11.1 15 6.0 4.1 2.8 3 0 0 3 3 3 0 Pro-corazonin SF3A3 PF16837.5 ETN99237.1 - 0.00083 19.8 9.6 0.47 11.0 0.0 4.8 3 2 1 4 4 4 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 YscJ_FliF PF01514.17 ETN99237.1 - 0.0088 15.7 3.8 0.0088 15.7 3.8 2.0 1 1 1 2 2 2 1 Secretory protein of YscJ/FliF family HsbA PF12296.8 ETN99237.1 - 0.17 12.3 1.9 18 5.8 0.1 3.2 2 1 0 3 3 3 0 Hydrophobic surface binding protein A T3SS_needle_E PF08988.10 ETN99237.1 - 0.39 10.9 6.1 4.1 7.6 0.4 3.5 3 0 0 3 3 3 0 Type III secretion system, cytoplasmic E component of needle T3SSipB PF16535.5 ETN99237.1 - 2 8.9 13.7 2.1 8.8 4.4 2.6 1 1 1 2 2 2 0 Type III cell invasion protein SipB DUF4407 PF14362.6 ETN99237.1 - 2.2 7.5 16.8 3.6 6.9 16.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 ETN99237.1 - 3.2 7.8 36.4 0.24 11.5 15.3 3.4 3 1 0 4 4 4 0 Modifier of rudimentary (Mod(r)) protein AAA_lid_9 PF17871.1 ETN99237.1 - 6.3 6.8 18.0 0.051 13.5 4.8 3.5 1 1 2 3 3 3 0 AAA lid domain Noelin-1 PF12308.8 ETN99237.1 - 7.1 6.7 14.9 2.2 8.3 2.4 3.9 3 1 1 4 4 4 0 Neurogenesis glycoprotein AgrB PF04647.15 ETN99238.1 - 0.29 10.4 5.2 0.69 9.2 5.2 1.7 1 1 0 1 1 1 0 Accessory gene regulator B DUF2116 PF09889.9 ETN99238.1 - 0.56 10.2 3.6 0.9 9.6 1.4 2.3 1 1 2 3 3 3 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Mst1_SARAH PF11629.8 ETN99240.1 - 0.083 13.0 0.2 0.17 12.0 0.2 1.6 1 0 0 1 1 1 0 C terminal SARAH domain of Mst1 PH_8 PF15409.6 ETN99241.1 - 0.028 14.7 0.1 0.045 14.0 0.1 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain Toxin_trans PF07952.12 ETN99242.1 - 0.064 12.3 1.1 0.076 12.1 1.1 1.3 1 1 0 1 1 1 0 Clostridium neurotoxin, Translocation domain PTS_EIIB PF00367.20 ETN99242.1 - 0.088 12.3 0.3 0.16 11.5 0.3 1.4 1 0 0 1 1 1 0 phosphotransferase system, EIIB Csm1_N PF18504.1 ETN99244.1 - 0.081 13.3 0.6 0.15 12.5 0.6 1.4 1 0 0 1 1 1 0 Csm1 N-terminal domain Ploopntkinase3 PF18751.1 ETN99244.1 - 0.17 11.7 0.0 0.22 11.4 0.0 1.1 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 FUR PF01475.19 ETN99245.1 - 0.0018 18.4 0.3 0.0026 17.9 0.3 1.3 1 0 0 1 1 1 1 Ferric uptake regulator family HTH_Tnp_Tc3_2 PF01498.18 ETN99245.1 - 0.0097 16.1 0.3 0.028 14.6 0.1 1.8 1 1 1 2 2 2 1 Transposase PKHD_C PF18331.1 ETN99246.1 - 0.051 13.6 0.3 6.7 6.9 0.1 2.8 3 0 0 3 3 3 0 PKHD-type hydroxylase C-terminal domain PGA_cap PF09587.10 ETN99246.1 - 0.2 11.1 5.0 0.32 10.4 5.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap LTD PF00932.19 ETN99247.1 - 0.00036 20.9 0.0 0.0039 17.5 0.0 2.0 1 1 0 1 1 1 1 Lamin Tail Domain DOCK-C2 PF14429.6 ETN99248.1 - 5.5e-22 78.5 0.2 5.5e-22 78.5 0.2 2.7 2 1 1 3 3 3 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 ETN99248.1 - 1.8e-15 56.7 0.0 5e-12 45.4 0.0 2.4 1 1 1 2 2 2 2 DOCK N-terminus DHR-2 PF06920.13 ETN99249.1 - 3.2e-53 181.2 9.5 8.7e-52 176.5 9.5 2.0 1 1 0 1 1 1 1 Dock homology region 2 GT-D PF08759.11 ETN99249.1 - 0.13 12.0 2.2 0.19 11.4 0.2 2.3 2 0 0 2 2 2 0 Glycosyltransferase GT-D fold CDC27 PF09507.10 ETN99251.1 - 0.013 14.9 33.1 0.017 14.5 33.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 ETN99251.1 - 0.028 12.7 30.9 0.037 12.3 30.9 1.2 1 0 0 1 1 1 0 CDC45-like protein REV PF00424.18 ETN99251.1 - 0.14 12.1 2.2 0.27 11.3 1.1 2.0 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) DNA_pol_phi PF04931.13 ETN99251.1 - 0.66 8.0 52.8 0.65 8.0 51.8 1.4 1 1 0 1 1 1 0 DNA polymerase phi Serinc PF03348.15 ETN99251.1 - 1.3 7.9 10.6 1.9 7.3 0.3 2.2 2 0 0 2 2 2 0 Serine incorporator (Serinc) Nop53 PF07767.11 ETN99251.1 - 2.6 7.3 44.5 10 5.4 44.5 1.8 1 1 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) eIF3_subunit PF08597.10 ETN99251.1 - 9.8 6.0 43.7 1.3 8.9 13.9 2.5 1 1 1 2 2 2 0 Translation initiation factor eIF3 subunit MBOAT PF03062.19 ETN99254.1 - 1.8 7.9 23.6 0.024 14.0 7.9 2.1 1 1 1 2 2 2 0 MBOAT, membrane-bound O-acyltransferase family G-gamma PF00631.22 ETN99255.1 - 0.0055 16.7 0.1 0.018 15.0 0.1 1.8 1 0 0 1 1 1 1 GGL domain Pterin_bind PF00809.22 ETN99255.1 - 0.045 13.4 0.9 0.092 12.4 0.9 1.5 1 0 0 1 1 1 0 Pterin binding enzyme ALS_ss_C PF10369.9 ETN99255.1 - 0.05 13.8 3.0 0.38 11.0 0.0 3.0 3 1 0 3 3 3 0 Small subunit of acetolactate synthase ETC_C1_NDUFA5 PF04716.14 ETN99255.1 - 0.12 12.2 0.1 0.12 12.2 0.1 3.1 4 0 0 4 4 4 0 ETC complex I subunit conserved region PIN_2 PF10130.9 ETN99255.1 - 1 9.6 6.6 0.36 11.1 3.4 1.9 2 0 0 2 2 2 0 PIN domain RNA_pol_Rpb5_C PF01191.19 ETN99255.1 - 2 8.3 8.3 3.9 7.4 0.1 3.5 3 1 0 3 3 3 0 RNA polymerase Rpb5, C-terminal domain Prominin PF05478.11 ETN99257.1 - 0.14 10.0 0.5 0.16 9.9 0.5 1.0 1 0 0 1 1 1 0 Prominin NOA36 PF06524.12 ETN99258.1 - 1.7 7.9 8.2 1.6 8.0 8.2 1.1 1 0 0 1 1 1 0 NOA36 protein Herpes_LMP1 PF05297.11 ETN99258.1 - 7.2 5.7 12.3 8 5.5 12.3 1.0 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DSPc PF00782.20 ETN99260.1 - 1.2e-06 28.4 0.3 2.3e-06 27.4 0.1 1.5 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain NPR3 PF03666.13 ETN99261.1 - 2.5 6.8 5.5 2.7 6.7 5.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETN99261.1 - 6.5 5.0 13.4 7.2 4.8 13.4 1.1 1 0 0 1 1 1 0 Menin Ras PF00071.22 ETN99262.1 - 5.8e-45 152.8 0.4 6.4e-45 152.6 0.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETN99262.1 - 5.8e-21 74.9 0.1 8.9e-21 74.3 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETN99262.1 - 1.1e-10 41.3 0.1 1.1e-10 41.2 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETN99262.1 - 0.028 14.0 0.0 0.078 12.5 0.0 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETN99262.1 - 0.067 13.1 0.1 0.094 12.6 0.1 1.4 1 1 0 1 1 1 0 RsgA GTPase CENP-M PF11111.8 ETN99262.1 - 0.069 12.3 0.1 0.088 12.0 0.1 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) CLN3 PF02487.17 ETN99264.1 - 0.059 12.4 0.4 0.078 12.0 0.4 1.1 1 0 0 1 1 1 0 CLN3 protein DUF3671 PF12420.8 ETN99264.1 - 1.3 9.1 6.9 0.57 10.3 4.4 1.7 2 0 0 2 2 2 0 Protein of unknown function DnaJ_C PF01556.18 ETN99266.1 - 0.0011 19.0 0.3 0.0091 16.1 0.3 2.0 1 1 0 1 1 1 1 DnaJ C terminal domain Transket_pyr PF02779.24 ETN99267.1 - 9.3e-56 188.3 0.0 1.2e-55 188.0 0.0 1.1 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ETN99267.1 - 0.11 11.4 0.1 0.17 10.8 0.1 1.3 1 0 0 1 1 1 0 Dehydrogenase E1 component WD40 PF00400.32 ETN99268.1 - 8.7e-06 26.4 2.3 0.0015 19.3 0.8 3.1 2 2 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN99268.1 - 0.0038 16.0 0.0 0.0041 15.8 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99268.1 - 0.061 13.6 0.0 0.13 12.6 0.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain BAP PF06639.11 ETN99268.1 - 0.094 13.1 0.1 0.23 11.8 0.0 1.6 1 1 1 2 2 2 0 Basal layer antifungal peptide (BAP) Actin PF00022.19 ETN99271.1 - 9e-16 57.5 0.0 9.9e-16 57.3 0.0 1.0 1 0 0 1 1 1 1 Actin DarA_N PF18788.1 ETN99271.1 - 0.09 12.9 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Defence against restriction A N-terminal Actin PF00022.19 ETN99272.1 - 1.5e-08 33.7 0.1 1.5e-08 33.7 0.1 1.1 1 0 0 1 1 1 1 Actin DUF386 PF04074.12 ETN99272.1 - 0.028 14.3 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 YhcH/YjgK/YiaL zf_C2H2_6 PF18450.1 ETN99273.1 - 0.039 13.7 2.9 0.039 13.7 2.9 2.4 3 0 0 3 3 3 0 Zinc Finger domain RsgA_GTPase PF03193.16 ETN99274.1 - 1.4e-06 28.4 0.2 1e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETN99274.1 - 0.00043 20.3 0.9 0.0019 18.2 0.1 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase PPV_E1_C PF00519.17 ETN99274.1 - 0.0012 17.8 2.7 0.3 9.9 0.5 2.3 2 1 0 2 2 2 2 Papillomavirus helicase DUF815 PF05673.13 ETN99274.1 - 0.0014 17.8 0.1 0.0028 16.9 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_PrkA PF08298.11 ETN99274.1 - 0.0028 16.6 0.1 0.0037 16.2 0.1 1.3 1 0 0 1 1 1 1 PrkA AAA domain ABC_tran PF00005.27 ETN99274.1 - 0.0076 16.8 0.2 0.0076 16.8 0.2 2.2 1 1 0 2 2 2 1 ABC transporter IstB_IS21 PF01695.17 ETN99274.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.6 ETN99274.1 - 0.088 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ETN99274.1 - 0.12 12.8 2.7 0.18 12.2 0.1 2.5 2 2 0 3 3 3 0 RNA helicase MoCF_biosynth PF00994.24 ETN99274.1 - 0.14 11.8 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Probable molybdopterin binding domain Coilin_N PF15862.5 ETN99274.1 - 0.38 10.6 11.3 0.66 9.8 11.3 1.4 1 0 0 1 1 1 0 Coilin N-terminus Endonuclease_NS PF01223.23 ETN99275.1 - 1.8e-14 54.1 0.1 2.1e-14 53.9 0.1 1.1 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease AAA_PrkA PF08298.11 ETN99279.1 - 0.025 13.5 0.3 0.025 13.5 0.3 1.4 2 0 0 2 2 2 0 PrkA AAA domain APG5 PF04106.12 ETN99279.1 - 0.026 14.1 1.0 0.092 12.3 0.4 1.9 1 1 1 2 2 2 0 Autophagy protein Apg5 PigN PF04987.14 ETN99280.1 - 0.0073 15.2 3.1 0.0073 15.2 3.1 1.4 2 0 0 2 2 2 1 Phosphatidylinositolglycan class N (PIG-N) Monooxygenase_B PF04744.12 ETN99280.1 - 0.021 13.7 5.4 0.025 13.4 5.4 1.1 1 0 0 1 1 1 0 Monooxygenase subunit B protein Ctr PF04145.15 ETN99280.1 - 0.1 13.2 2.0 0.13 12.8 2.0 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Presenilin PF01080.17 ETN99280.1 - 0.19 10.4 5.8 0.24 10.1 5.8 1.2 1 0 0 1 1 1 0 Presenilin DivIC PF04977.15 ETN99280.1 - 0.83 9.5 21.4 0.92 9.3 11.4 2.2 2 0 0 2 2 2 0 Septum formation initiator FAM70 PF14967.6 ETN99280.1 - 0.89 9.0 7.2 1 8.8 7.2 1.1 1 0 0 1 1 1 0 FAM70 protein FliJ PF02050.16 ETN99280.1 - 1.2 9.4 28.7 2.9 8.1 28.7 1.6 1 1 0 1 1 1 0 Flagellar FliJ protein PspB PF06667.12 ETN99280.1 - 4.9 7.3 9.0 0.57 10.3 3.8 2.0 2 0 0 2 2 2 0 Phage shock protein B Peroxin-13_N PF04088.13 ETN99280.1 - 6 7.1 9.8 0.3 11.3 1.4 2.0 1 1 1 2 2 2 0 Peroxin 13, N-terminal region DUF2508 PF10704.9 ETN99281.1 - 0.018 15.2 2.4 0.018 15.2 2.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2508) GlutR_dimer PF00745.20 ETN99282.1 - 1.1 9.8 7.5 4.5 7.8 2.7 2.1 1 1 1 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain RBM39linker PF15519.6 ETN99284.1 - 0.007 17.4 0.5 0.007 17.4 0.5 2.0 2 0 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein zf-CCHC PF00098.23 ETN99284.1 - 0.13 12.4 13.2 0.14 12.3 1.1 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 ETN99284.1 - 0.4 10.5 6.3 1.2 8.9 0.1 2.5 2 0 0 2 2 2 0 Zinc knuckle OTOS PF15182.6 ETN99285.1 - 0.12 12.3 0.2 0.36 10.8 0.2 1.7 1 1 1 2 2 2 0 Otospiralin Kelch_6 PF13964.6 ETN99286.1 - 5.1e-05 23.4 0.7 0.16 12.3 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETN99286.1 - 8.6e-05 22.0 1.4 0.13 11.9 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETN99286.1 - 0.00019 21.3 1.4 0.85 9.7 0.3 3.1 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETN99286.1 - 0.003 17.5 1.0 0.77 9.8 0.0 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN99286.1 - 0.005 16.8 3.1 1.2 9.2 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Myco_haema PF05692.12 ETN99286.1 - 0.0087 15.1 3.3 0.01 14.9 3.3 1.1 1 0 0 1 1 1 1 Mycoplasma haemagglutinin Kelch_3 PF13415.6 ETN99286.1 - 0.27 11.6 1.3 20 5.6 0.1 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain NACHT PF05729.12 ETN99287.1 - 8.2e-09 35.6 0.0 1.8e-08 34.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETN99287.1 - 0.00032 21.0 0.3 0.0027 18.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETN99287.1 - 0.014 15.9 0.0 0.014 15.9 0.0 3.6 4 0 0 4 4 4 0 AAA domain TsaE PF02367.17 ETN99287.1 - 0.078 13.0 0.1 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ETN99287.1 - 0.092 13.2 0.0 0.33 11.4 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ETN99287.1 - 0.17 12.4 1.3 0.42 11.1 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ETN99287.1 - 0.23 11.9 0.1 1.2 9.6 0.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ETN99287.1 - 0.76 10.2 0.0 0.76 10.2 0.0 3.7 4 0 0 4 4 4 0 RNA helicase DUF4920 PF16267.5 ETN99288.1 - 0.14 12.2 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4920) HEAT PF02985.22 ETN99289.1 - 0.024 14.8 0.0 0.19 12.1 0.0 2.3 3 0 0 3 3 3 0 HEAT repeat HEAT_2 PF13646.6 ETN99289.1 - 0.19 12.2 0.0 0.25 11.7 0.0 1.4 1 1 0 1 1 1 0 HEAT repeats HemY_N PF07219.13 ETN99290.1 - 0.62 10.3 7.7 4.8 7.4 0.1 2.7 2 1 0 3 3 3 0 HemY protein N-terminus LEDGF PF11467.8 ETN99291.1 - 0.056 13.1 1.5 0.15 11.7 1.5 1.7 1 1 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) ENTH PF01417.20 ETN99291.1 - 0.058 13.4 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 ENTH domain OMPdecase PF00215.24 ETN99292.1 - 4.6e-69 232.4 0.0 7.3e-69 231.8 0.0 1.3 1 0 0 1 1 1 1 Orotidine 5'-phosphate decarboxylase / HUMPS family Pribosyltran PF00156.27 ETN99292.1 - 2e-09 37.1 0.0 3.9e-09 36.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Rep_fac_C PF08542.11 ETN99293.1 - 1.9e-13 50.6 0.4 1.1e-12 48.2 0.1 2.1 2 0 0 2 2 2 1 Replication factor C C-terminal domain DNA_pol3_delta2 PF13177.6 ETN99293.1 - 9.6e-11 41.7 0.0 1.8e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 DNA polymerase III, delta subunit AAA PF00004.29 ETN99293.1 - 8.8e-06 26.2 0.0 2.1e-05 25.0 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_assoc_2 PF16193.5 ETN99293.1 - 2.1e-05 24.7 0.6 6.5e-05 23.2 0.1 2.1 2 0 0 2 2 2 1 AAA C-terminal domain DNA_pol3_delta PF06144.13 ETN99293.1 - 0.017 14.9 0.0 0.043 13.6 0.0 1.6 1 0 0 1 1 1 0 DNA polymerase III, delta subunit TIP49_C PF17856.1 ETN99293.1 - 0.019 15.1 1.9 0.027 14.6 0.2 2.1 3 0 0 3 3 3 0 TIP49 AAA-lid domain DUF2075 PF09848.9 ETN99293.1 - 0.035 13.3 0.0 0.068 12.4 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) MCM2_N PF12619.8 ETN99294.1 - 0.051 13.9 0.9 0.08 13.2 0.1 1.6 2 0 0 2 2 2 0 Mini-chromosome maintenance protein 2 Nrap_D2 PF17403.2 ETN99295.1 - 0.059 13.1 0.0 0.085 12.6 0.0 1.3 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain DHR-2 PF06920.13 ETN99297.1 - 0.15 10.7 0.1 0.15 10.7 0.1 1.0 1 0 0 1 1 1 0 Dock homology region 2 WD40 PF00400.32 ETN99298.1 - 1.1e-10 41.8 4.2 0.00014 22.5 0.3 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99298.1 - 0.041 14.2 0.0 5.3 7.4 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99298.1 - 0.1 11.2 0.1 0.48 9.0 0.0 1.8 1 1 1 2 2 2 0 Nucleoporin Nup120/160 OSTbeta PF15048.6 ETN99300.1 - 1 9.5 7.0 1.4 9.0 1.0 2.6 1 1 1 2 2 2 0 Organic solute transporter subunit beta protein NLRC4_HD2 PF17776.1 ETN99301.1 - 0.0069 16.9 3.3 0.022 15.3 0.1 2.9 3 0 0 3 3 3 1 NLRC4 helical domain HD2 Cnd1 PF12717.7 ETN99301.1 - 0.029 14.4 1.7 0.054 13.5 0.4 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF3181 PF11378.8 ETN99301.1 - 0.068 13.5 0.0 0.3 11.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3181) HEAT PF02985.22 ETN99301.1 - 0.15 12.4 0.0 22 5.6 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat HEAT_2 PF13646.6 ETN99301.1 - 0.15 12.5 0.0 5.6 7.4 0.0 2.9 2 1 1 3 3 3 0 HEAT repeats Phage_holin_6_1 PF09682.10 ETN99301.1 - 0.26 11.7 0.7 5.9 7.4 0.0 3.0 3 0 0 3 3 3 0 Bacteriophage holin of superfamily 6 (Holin_LLH) JHD PF17811.1 ETN99301.1 - 0.83 10.2 3.7 0.79 10.3 0.1 2.8 4 0 0 4 4 4 0 Jumonji helical domain Peptidase_C14 PF00656.22 ETN99302.1 - 5.6e-06 26.5 0.0 1e-05 25.7 0.0 1.4 1 1 0 1 1 1 1 Caspase domain Cofilin_ADF PF00241.20 ETN99303.1 - 0.042 13.6 0.0 0.61 9.9 0.0 2.1 2 0 0 2 2 2 0 Cofilin/tropomyosin-type actin-binding protein DUF1398 PF07166.11 ETN99304.1 - 0.092 12.8 2.1 0.15 12.2 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1398) SATase_N PF06426.14 ETN99305.1 - 0.0019 18.5 1.0 0.0022 18.3 1.0 1.1 1 0 0 1 1 1 1 Serine acetyltransferase, N-terminal Ca_bind_SSO6904 PF18249.1 ETN99305.1 - 0.0085 16.4 0.9 0.012 16.0 0.6 1.6 1 1 0 1 1 1 1 Calcium binding protein SSO6904 IL15 PF02372.15 ETN99305.1 - 0.047 13.7 4.4 0.085 12.9 4.4 1.5 1 1 0 1 1 1 0 Interleukin 15 CT_C_D PF02682.16 ETN99305.1 - 0.14 11.9 0.7 0.15 11.8 0.7 1.0 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D KxDL PF10241.9 ETN99305.1 - 0.32 11.3 13.8 2.4 8.5 3.7 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein FlgT_N PF16548.5 ETN99305.1 - 0.34 11.5 4.5 0.42 11.2 3.9 1.5 1 1 0 1 1 1 0 Flagellar assembly protein T, N-terminal domain SPATA24 PF15175.6 ETN99305.1 - 0.6 10.0 14.5 0.29 11.0 4.8 2.0 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 DUF4795 PF16043.5 ETN99305.1 - 0.72 9.4 11.6 1.1 8.8 11.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) PAP_central PF04928.17 ETN99305.1 - 1.6 7.6 7.3 1.8 7.5 7.3 1.0 1 0 0 1 1 1 0 Poly(A) polymerase central domain CRT10 PF08728.10 ETN99306.1 - 0.29 9.3 13.0 0.3 9.2 13.0 1.0 1 0 0 1 1 1 0 CRT10 WD40 PF00400.32 ETN99308.1 - 1.3e-37 127.1 17.3 5.1e-12 46.1 0.1 5.2 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99308.1 - 3.2e-19 69.0 0.3 5.2e-05 23.5 0.0 3.7 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETN99308.1 - 2.2e-07 31.0 0.0 0.00075 19.4 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETN99308.1 - 2.9e-07 30.1 0.0 0.00086 18.7 0.0 2.7 1 1 0 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETN99308.1 - 1.8e-06 27.1 0.0 0.56 9.1 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN99308.1 - 0.00011 22.0 1.0 9.1 6.4 0.0 3.5 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Titin_Ig-rpts PF06582.12 ETN99308.1 - 0.00019 21.3 1.3 15 5.6 0.0 4.3 4 0 0 4 4 4 0 Titin repeat Frtz PF11768.8 ETN99308.1 - 0.00083 17.8 0.0 3.1 6.0 0.0 2.9 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETN99308.1 - 0.0011 19.0 5.9 4.4 7.4 0.1 3.7 1 1 3 4 4 4 3 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETN99308.1 - 0.0014 18.3 0.1 0.064 12.8 0.1 2.3 1 1 0 2 2 2 1 PQQ-like domain GspH PF12019.8 ETN99308.1 - 0.002 18.5 1.6 0.74 10.3 0.1 2.8 1 1 2 3 3 3 1 Type II transport protein GspH Nup160 PF11715.8 ETN99308.1 - 0.0025 16.6 0.5 3.4 6.2 0.0 3.2 1 1 2 3 3 3 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETN99308.1 - 0.0038 15.8 0.1 1.6 7.1 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETN99308.1 - 0.013 15.4 0.0 19 5.4 0.0 3.4 4 0 0 4 4 4 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETN99308.1 - 0.013 15.2 2.6 23 4.8 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature CSN4_RPN5_eIF3a PF18420.1 ETN99308.1 - 4.4 7.6 8.0 55 4.0 0.1 4.0 4 0 0 4 4 4 0 CSN4/RPN5/eIF3a helix turn helix domain PDEase_I PF00233.19 ETN99309.1 - 0.049 13.4 1.7 0.071 12.8 1.7 1.4 1 1 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase IL15 PF02372.15 ETN99309.1 - 4.2 7.4 7.1 14 5.7 0.5 2.8 2 1 1 3 3 3 0 Interleukin 15 ACBP PF00887.19 ETN99311.1 - 0.039 14.2 2.0 0.039 14.2 2.0 1.7 1 1 0 1 1 1 0 Acyl CoA binding protein Ndc1_Nup PF09531.10 ETN99311.1 - 7.3 5.1 11.3 8 5.0 11.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Sin_N PF04801.13 ETN99311.1 - 7.9 5.6 17.7 8.4 5.5 17.7 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region PDEase_I PF00233.19 ETN99312.1 - 9.4e-73 244.8 0.0 1.7e-72 244.0 0.0 1.4 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETN99312.1 - 0.035 14.3 0.0 0.057 13.6 0.0 1.4 1 0 0 1 1 1 0 HD domain Sigma70_ner PF04546.13 ETN99312.1 - 0.13 12.2 3.3 0.19 11.6 3.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region RRN3 PF05327.11 ETN99312.1 - 0.17 10.4 2.3 0.23 9.9 2.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GCIP PF13324.6 ETN99312.1 - 3.7 7.1 6.5 5.6 6.5 6.5 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF2457 PF10446.9 ETN99312.1 - 4.3 6.4 12.9 6.1 5.9 12.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Roughex PF06020.11 ETN99312.1 - 7.7 5.5 6.3 11 5.0 6.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein NOA36 PF06524.12 ETN99312.1 - 9.1 5.5 12.4 16 4.7 12.4 1.3 1 0 0 1 1 1 0 NOA36 protein SAM_1 PF00536.30 ETN99313.1 - 3.9e-05 24.0 0.1 0.17 12.3 0.0 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN99313.1 - 0.0018 18.3 0.1 0.52 10.5 0.1 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) NCD1 PF04904.13 ETN99313.1 - 0.0023 17.9 0.1 0.0046 16.9 0.1 1.5 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) PUB PF09409.10 ETN99315.1 - 0.0067 16.3 1.9 0.015 15.2 1.9 1.7 1 1 0 1 1 1 1 PUB domain WD40 PF00400.32 ETN99316.1 - 7.9e-17 61.3 8.1 7.1e-06 26.7 0.0 4.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN99316.1 - 0.01 14.6 0.0 2.1 6.9 0.0 2.5 2 1 0 3 3 3 0 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99316.1 - 0.016 14.6 3.4 0.11 11.8 0.3 2.3 1 1 0 2 2 2 0 WD40-like domain Nucleoporin_N PF08801.11 ETN99316.1 - 0.1 11.4 4.9 0.28 9.9 4.9 1.8 1 1 0 1 1 1 0 Nup133 N terminal like TetM_leader PF08076.11 ETN99316.1 - 0.36 10.6 1.7 44 4.0 0.1 3.1 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide FA_desaturase PF00487.24 ETN99317.1 - 1.9 8.2 13.5 0.79 9.5 11.2 1.5 1 1 0 1 1 1 0 Fatty acid desaturase WD40 PF00400.32 ETN99318.1 - 3e-09 37.3 8.1 0.0034 18.2 0.1 4.2 3 1 0 3 3 3 3 WD domain, G-beta repeat RasGEF_N PF00618.20 ETN99318.1 - 0.0071 16.6 0.1 0.0094 16.2 0.1 1.3 1 0 0 1 1 1 1 RasGEF N-terminal motif ANAPC4_WD40 PF12894.7 ETN99318.1 - 0.018 15.3 0.1 2.9 8.2 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3438 PF11920.8 ETN99320.1 - 0.44 9.7 1.1 0.58 9.3 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) Zip PF02535.22 ETN99320.1 - 0.55 9.4 3.2 0.54 9.4 3.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETN99320.1 - 0.71 8.2 9.4 0.71 8.2 9.4 1.0 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETN99320.1 - 1.5 7.5 5.0 1.5 7.5 5.0 1.1 1 0 0 1 1 1 0 Presenilin DUF2076 PF09849.9 ETN99320.1 - 2.2 8.3 11.0 2.6 8.0 11.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Orf78 PF06024.12 ETN99320.1 - 4.6 7.6 8.9 8.3 6.8 8.9 1.5 1 0 0 1 1 1 0 Orf78 (ac78) ABC2_membrane_3 PF12698.7 ETN99320.1 - 5.4 6.0 6.3 5.7 5.9 6.3 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein TPR_8 PF13181.6 ETN99321.1 - 1.1e-05 25.2 0.6 0.052 13.8 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETN99321.1 - 2.7e-05 24.4 1.5 0.12 12.7 0.6 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99321.1 - 0.0014 18.3 3.5 0.51 10.2 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99321.1 - 0.029 14.6 0.5 0.074 13.3 0.4 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETN99321.1 - 0.11 12.7 2.6 3.5 8.0 0.3 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99321.1 - 0.15 12.7 0.1 0.39 11.4 0.1 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Receptor_2B4 PF11465.8 ETN99321.1 - 0.31 11.3 0.0 0.31 11.3 0.0 2.9 3 0 0 3 3 3 0 Natural killer cell receptor 2B4 SID-1_RNA_chan PF13965.6 ETN99322.1 - 1.1 7.5 4.4 0.14 10.5 0.2 1.5 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PH PF00169.29 ETN99323.1 - 0.00026 21.5 0.1 0.00044 20.7 0.1 1.3 1 0 0 1 1 1 1 PH domain Med3 PF11593.8 ETN99324.1 - 0.0012 18.2 1.9 0.0012 18.2 1.9 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal DNA_pol3_tau_4 PF12168.8 ETN99324.1 - 0.056 14.0 4.9 0.087 13.4 4.9 1.3 1 0 0 1 1 1 0 DNA polymerase III subunits tau domain IV DnaB-binding Kei1 PF08552.11 ETN99324.1 - 0.13 12.2 0.1 0.17 11.8 0.1 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Peptidase_M1 PF01433.20 ETN99325.1 - 1.8e-38 132.3 0.1 6.5e-38 130.5 0.1 1.8 1 1 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ETN99325.1 - 1.4e-14 54.7 0.2 5.4e-14 52.8 0.1 1.9 2 0 0 2 2 2 1 Peptidase M1 N-terminal domain DUF3458 PF11940.8 ETN99325.1 - 0.0029 18.0 0.0 0.0067 16.9 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold DUF2777 PF10949.8 ETN99326.1 - 0.073 12.7 5.3 0.1 12.2 5.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) Glyco_transf_22 PF03901.17 ETN99327.1 - 0.00024 20.5 5.1 0.00024 20.5 5.1 1.9 3 0 0 3 3 3 1 Alg9-like mannosyltransferase family Glyco_transf_22 PF03901.17 ETN99328.1 - 2.9e-16 59.7 23.7 4.8e-10 39.3 9.0 3.1 2 1 1 3 3 3 2 Alg9-like mannosyltransferase family Virul_fac_BrkB PF03631.15 ETN99328.1 - 0.95 9.0 7.2 0.075 12.6 0.5 2.4 3 0 0 3 3 3 0 Virulence factor BrkB Herpes_UL73 PF03554.13 ETN99330.1 - 0.32 11.0 2.9 3 7.9 0.3 2.1 1 1 1 2 2 2 0 UL73 viral envelope glycoprotein LRRC37AB_C PF14914.6 ETN99331.1 - 0.074 13.0 0.4 0.074 13.0 0.4 1.5 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Phage_CII PF05269.11 ETN99332.1 - 0.021 15.0 1.3 1.5 9.1 0.2 2.2 2 0 0 2 2 2 0 Bacteriophage CII protein NACHT PF05729.12 ETN99333.1 - 1.4e-10 41.3 0.0 2.7e-10 40.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain ATP_bind_2 PF03668.15 ETN99333.1 - 9.5e-05 21.8 0.0 0.00019 20.9 0.0 1.4 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_22 PF13401.6 ETN99333.1 - 0.00099 19.4 0.0 0.0046 17.2 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETN99333.1 - 0.0011 19.5 0.1 0.0053 17.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETN99333.1 - 0.013 15.0 0.1 0.036 13.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region CbiA PF01656.23 ETN99333.1 - 0.015 15.4 0.0 6.2 6.9 0.0 2.7 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain OTOS PF15182.6 ETN99333.1 - 0.099 12.6 0.3 0.46 10.4 0.1 2.3 2 0 0 2 2 2 0 Otospiralin RNA_helicase PF00910.22 ETN99333.1 - 0.15 12.4 0.1 0.15 12.4 0.1 2.9 3 1 0 3 3 3 0 RNA helicase AAA_16 PF13191.6 ETN99333.1 - 0.16 12.4 0.1 0.87 9.9 0.0 2.4 3 1 0 3 3 3 0 AAA ATPase domain Pneumo_M2 PF07380.11 ETN99333.1 - 0.35 11.2 3.5 0.92 9.8 0.2 3.3 2 1 0 2 2 2 0 Pneumovirus M2 protein ABC_tran PF00005.27 ETN99333.1 - 0.36 11.3 5.4 0.3 11.6 3.1 2.1 2 1 0 2 2 1 0 ABC transporter RelA_SpoT PF04607.17 ETN99334.1 - 0.0054 17.0 1.0 0.012 15.9 0.1 1.9 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins ATP-cone PF03477.16 ETN99334.1 - 0.018 15.6 0.6 10 6.8 0.1 2.4 2 0 0 2 2 2 0 ATP cone domain DUF2209 PF09974.9 ETN99334.1 - 0.051 13.9 0.1 0.44 10.9 0.0 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2209) Csm2_III-A PF03750.13 ETN99334.1 - 0.61 10.9 6.0 1.6 9.6 1.6 2.9 1 1 0 2 2 2 0 Csm2 Type III-A DUF3658 PF12395.8 ETN99335.1 - 0.0096 15.8 0.5 0.024 14.5 0.5 1.7 1 0 0 1 1 1 1 Protein of unknown function FUSC PF04632.12 ETN99335.1 - 1.8 7.0 2.9 4.2 5.8 2.9 1.7 1 1 0 1 1 1 0 Fusaric acid resistance protein family BCL_N PF04714.13 ETN99335.1 - 3.3 7.8 5.5 1.1 9.4 0.5 2.6 3 0 0 3 3 3 0 BCL7, N-terminal conserver region DUF4407 PF14362.6 ETN99335.1 - 8.4 5.7 13.0 11 5.2 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_C14 PF00656.22 ETN99336.1 - 1.6e-14 54.4 0.3 1.8e-14 54.3 0.3 1.0 1 0 0 1 1 1 1 Caspase domain NblA PF04485.12 ETN99336.1 - 0.0048 17.3 0.1 0.0078 16.6 0.1 1.3 1 0 0 1 1 1 1 Phycobilisome degradation protein nblA Rep_2 PF01719.17 ETN99336.1 - 0.031 14.1 0.3 0.066 13.0 0.2 1.6 1 1 1 2 2 2 0 Plasmid replication protein Phage_int_SAM_4 PF13495.6 ETN99336.1 - 0.13 12.8 0.1 0.21 12.1 0.1 1.4 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain TPR_12 PF13424.6 ETN99337.1 - 2.1e-177 575.8 61.6 2e-16 60.0 0.2 14.1 4 3 10 15 15 15 15 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99337.1 - 2.4e-132 427.8 8.8 5.7e-08 32.4 0.1 20.2 18 1 2 20 20 20 19 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99337.1 - 2.1e-109 353.3 145.9 1.7e-08 33.9 1.2 20.3 19 1 1 20 20 20 19 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99337.1 - 8.4e-85 272.8 55.4 3.3e-06 26.7 0.1 20.2 18 1 2 20 20 20 18 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99337.1 - 7.6e-81 259.9 118.1 3.4e-07 29.9 0.6 20.1 18 1 2 20 20 20 16 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99337.1 - 7.6e-62 200.4 141.4 3.4e-06 26.8 2.7 19.8 18 1 2 20 20 20 16 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99337.1 - 2.2e-34 115.3 37.4 0.01 16.1 0.1 19.0 18 2 1 19 19 18 8 Tetratricopeptide repeat TPR_6 PF13174.6 ETN99337.1 - 1.7e-31 106.7 29.6 0.065 13.9 0.1 16.0 16 1 1 17 17 16 8 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99337.1 - 2.5e-29 101.6 0.0 0.024 15.3 0.0 13.3 11 3 4 15 15 13 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99337.1 - 3e-27 94.0 119.7 3.1e-05 23.6 1.2 22.9 21 7 7 28 28 26 14 TPR repeat TPR_14 PF13428.6 ETN99337.1 - 1.1e-21 75.6 5.5 2.8 9.0 0.0 15.9 16 2 3 19 19 16 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETN99337.1 - 1.2e-18 67.6 0.0 0.04 13.3 0.0 6.1 2 2 4 6 6 6 5 MalT-like TPR region DUF5113 PF17140.4 ETN99337.1 - 1.1e-12 48.1 60.9 0.35 10.6 0.6 16.2 14 4 2 17 17 17 5 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETN99337.1 - 5e-11 42.7 37.2 0.25 11.6 0.2 10.9 7 3 3 10 10 10 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETN99337.1 - 5.9e-08 32.8 0.0 3.9 7.7 0.1 8.0 8 2 0 8 8 8 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETN99337.1 - 1.3e-07 31.4 47.2 0.0028 17.6 2.4 11.3 11 0 0 11 11 11 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETN99337.1 - 1.2e-05 25.8 14.9 4.3 7.9 0.1 9.5 5 4 6 11 11 11 1 Tetratricopeptide repeat POR PF01558.18 ETN99337.1 - 2.2e-05 24.6 3.2 0.084 12.9 0.1 5.1 4 2 1 6 6 6 1 Pyruvate ferredoxin/flavodoxin oxidoreductase PPR PF01535.20 ETN99337.1 - 0.00014 21.8 61.6 3.8 8.0 0.1 16.6 19 0 0 19 19 19 1 PPR repeat DUF4810 PF16068.5 ETN99337.1 - 0.00034 21.1 21.8 13 6.4 0.0 10.0 9 2 2 11 11 11 0 Domain of unknown function (DUF4810) DUF5475 PF17569.2 ETN99337.1 - 0.00047 20.4 10.1 24 5.3 0.0 9.3 11 1 3 14 14 11 0 Family of unknown function (DUF5475) SHNi-TPR PF10516.9 ETN99337.1 - 0.0019 17.6 11.7 0.17 11.4 0.0 7.9 9 0 0 9 9 9 1 SHNi-TPR Ten1_2 PF15490.6 ETN99337.1 - 0.0088 15.8 0.6 1.1e+02 2.6 0.0 5.6 5 1 1 6 6 6 0 Telomere-capping, CST complex subunit Med9 PF07544.13 ETN99337.1 - 0.055 13.6 12.0 14 5.8 0.1 6.8 9 0 0 9 9 6 0 RNA polymerase II transcription mediator complex subunit 9 Ubiq-assoc PF09145.10 ETN99337.1 - 0.099 12.6 0.3 0.099 12.6 0.3 14.4 15 3 2 17 17 14 0 Ubiquitin-associated Rapsyn_N PF10579.9 ETN99337.1 - 0.43 10.7 26.4 11 6.2 0.0 9.2 9 2 2 11 11 10 0 Rapsyn N-terminal myristoylation and linker region ATP-sulfurylase PF01747.17 ETN99337.1 - 0.48 9.8 3.5 37 3.7 0.0 4.5 4 2 1 5 5 5 0 ATP-sulfurylase Peptidase_M99_C PF17129.4 ETN99337.1 - 0.86 9.8 5.6 19 5.5 0.1 4.4 3 0 0 3 3 3 0 C-terminal domain of metallo-carboxypeptidase Mob_Pre PF01076.19 ETN99337.1 - 1.1 9.0 41.6 0.83 9.4 0.6 6.6 2 2 5 7 7 7 0 Plasmid recombination enzyme Orf78 PF06024.12 ETN99339.1 - 0.0019 18.5 0.8 0.0031 17.8 0.8 1.4 1 0 0 1 1 1 1 Orf78 (ac78) SNX17_FERM_C PF18116.1 ETN99339.1 - 0.015 15.4 1.1 0.026 14.6 1.1 1.3 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain DUF4834 PF16118.5 ETN99339.1 - 0.19 12.7 2.2 0.29 12.1 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) GBP_C PF02841.14 ETN99340.1 - 0.013 14.9 6.0 0.015 14.7 6.0 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain NdhM PF10664.9 ETN99341.1 - 0.13 12.6 0.1 0.13 12.6 0.1 4.2 5 1 0 5 5 5 0 Cyanobacterial and plastid NDH-1 subunit M DUF4092 PF13322.6 ETN99341.1 - 1.3 8.9 4.1 1.2 9.0 1.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4092) Adap_comp_sub PF00928.21 ETN99343.1 - 2.1e-49 168.3 1.3 2.7e-49 167.9 1.3 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family AAA_9 PF12781.7 ETN99344.1 - 0.028 13.6 0.0 0.036 13.2 0.0 1.1 1 0 0 1 1 1 0 ATP-binding dynein motor region Choline_sulf_C PF12411.8 ETN99345.1 - 0.017 14.9 0.3 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal ANAPC4_WD40 PF12894.7 ETN99346.1 - 0.052 13.9 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 ETN99346.1 - 0.1 11.4 0.0 0.13 11.0 0.0 1.1 1 0 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region WD40 PF00400.32 ETN99347.1 - 8.3e-06 26.5 0.5 8.3e-06 26.5 0.5 4.1 4 1 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99347.1 - 0.0016 18.7 0.4 0.074 13.4 0.0 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN99347.1 - 0.0017 17.2 1.2 0.049 12.4 0.1 2.0 1 1 0 2 2 2 2 Nup133 N terminal like Nup160 PF11715.8 ETN99347.1 - 0.011 14.4 1.1 0.026 13.2 0.5 1.6 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ENOD93 PF03386.14 ETN99347.1 - 0.13 12.1 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein WD40 PF00400.32 ETN99348.1 - 5e-16 58.8 10.7 3.7e-06 27.6 0.6 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN99348.1 - 2.8e-06 26.3 0.3 0.044 12.4 0.1 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99348.1 - 1.1e-05 25.7 0.2 0.13 12.5 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99348.1 - 0.00078 18.9 0.4 0.022 14.1 0.1 2.1 1 1 0 2 2 2 1 WD40-like domain TetM_leader PF08076.11 ETN99348.1 - 0.052 13.3 0.2 8.6 6.2 0.0 3.3 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide WYL_2 PF10902.8 ETN99348.1 - 0.13 12.7 0.6 12 6.4 0.0 2.7 2 1 1 3 3 3 0 WYL_2, Sm-like SH3 beta-barrel fold Guanylate_cyc PF00211.20 ETN99351.1 - 1.4e-19 70.5 0.5 3.4e-19 69.2 0.5 1.6 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain zf-RanBP PF00641.18 ETN99352.1 - 0.0011 18.3 0.4 0.0017 17.6 0.4 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RFXA_RFXANK_bdg PF15289.6 ETN99352.1 - 0.023 15.0 3.4 0.04 14.2 3.4 1.5 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain Vps36-NZF-N PF16988.5 ETN99352.1 - 0.04 13.3 0.2 0.11 11.9 0.2 1.8 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ETN99352.1 - 0.054 13.6 0.1 0.098 12.7 0.1 1.3 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger Syntaxin_2 PF14523.6 ETN99353.1 - 0.044 14.1 6.1 0.58 10.6 6.1 2.4 1 1 0 1 1 1 0 Syntaxin-like protein GPS PF01825.21 ETN99357.1 - 0.0036 17.8 2.2 0.013 16.0 2.2 2.0 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Pox_Ag35 PF03286.14 ETN99360.1 - 0.1 12.4 6.2 0.14 12.0 6.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PRiA4_ORF3 PF07929.11 ETN99360.1 - 1 9.0 8.7 0.22 11.2 4.9 1.7 1 1 1 2 2 2 0 Plasmid pRiA4b ORF-3-like protein DUF4164 PF13747.6 ETN99360.1 - 1.2 9.4 9.7 3.1 8.1 2.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) Tox-ODYAM1 PF15642.6 ETN99360.1 - 3.2 6.6 10.3 0.098 11.6 2.8 1.8 2 0 0 2 2 2 0 Toxin in Odyssella and Amoebophilus HIP1_clath_bdg PF16515.5 ETN99360.1 - 4.4 8.0 16.0 1.3 9.7 7.3 2.2 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 bZIP_Maf PF03131.17 ETN99360.1 - 6 7.5 15.6 0.4 11.2 3.9 2.4 2 1 0 2 2 2 0 bZIP Maf transcription factor DUF3112 PF11309.8 ETN99360.1 - 9.7 5.6 7.4 0.99 8.8 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3112) HEAT PF02985.22 ETN99361.1 - 1.1e-09 37.7 0.0 0.046 14.0 0.0 5.4 6 0 0 6 6 5 2 HEAT repeat Ank_3 PF13606.6 ETN99361.1 - 1e-05 25.5 0.1 0.00055 20.2 0.0 4.0 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 ETN99361.1 - 0.00015 22.2 0.1 0.0037 17.8 0.1 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETN99361.1 - 0.00044 20.5 0.0 0.0019 18.5 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETN99361.1 - 0.0011 19.6 0.8 0.027 15.0 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) HEAT_2 PF13646.6 ETN99361.1 - 0.0025 18.2 0.0 3.8 8.0 0.0 3.6 3 1 1 4 4 3 1 HEAT repeats Ank PF00023.30 ETN99361.1 - 0.015 15.7 0.0 0.068 13.7 0.0 2.2 1 0 0 1 1 1 0 Ankyrin repeat DNA_pol3_gamma3 PF12169.8 ETN99361.1 - 0.024 14.6 0.4 23 4.9 0.0 3.6 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III Cnd1 PF12717.7 ETN99361.1 - 0.46 10.5 17.5 4.5 7.3 3.4 4.2 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 FPL PF09758.9 ETN99361.1 - 0.91 9.5 25.1 0.83 9.6 0.2 6.8 2 2 3 5 5 5 0 Uncharacterised conserved protein Sec23_helical PF04815.15 ETN99361.1 - 1.7 8.5 4.9 73 3.3 0.1 4.2 3 1 0 3 3 3 0 Sec23/Sec24 helical domain Ku_PK_bind PF08785.11 ETN99361.1 - 1.8 8.7 8.2 0.35 11.0 1.0 3.7 5 1 0 5 5 5 0 Ku C terminal domain like HEAT PF02985.22 ETN99362.1 - 2.4e-08 33.5 0.1 0.19 12.1 0.0 7.0 7 0 0 7 7 7 1 HEAT repeat Dopey_N PF04118.14 ETN99362.1 - 1.3e-05 24.5 23.7 0.00011 21.5 3.5 4.3 1 1 3 4 4 4 2 Dopey, N-terminal HEAT_2 PF13646.6 ETN99362.1 - 1.6e-05 25.2 0.0 0.036 14.5 0.0 4.8 3 1 4 7 7 7 3 HEAT repeats HEAT_EZ PF13513.6 ETN99362.1 - 0.011 16.2 0.0 1.2 9.7 0.0 4.0 4 1 1 5 5 5 0 HEAT-like repeat RTP1_C1 PF10363.9 ETN99362.1 - 0.018 15.2 21.6 1.3 9.2 0.8 6.0 3 2 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 Tfb5 PF06331.12 ETN99362.1 - 0.061 13.3 0.3 0.061 13.3 0.3 5.7 7 2 1 8 8 8 0 Transcription factor TFIIH complex subunit Tfb5 MEDS PF14417.6 ETN99362.1 - 0.09 12.6 0.1 2.7 7.8 0.0 3.3 4 0 0 4 4 4 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain Collectrin PF16959.5 ETN99362.1 - 0.11 12.2 3.7 5.4 6.8 0.2 2.9 2 1 0 2 2 2 0 Renal amino acid transporter LuxT_C PF18285.1 ETN99362.1 - 0.14 12.7 5.3 21 5.7 0.4 5.2 3 1 1 4 4 4 0 Tetracycline repressor LuxT C-terminal domain DUF4508 PF14969.6 ETN99362.1 - 0.4 11.0 14.4 0.68 10.2 0.1 4.9 4 3 1 5 5 5 0 Domain of unknown function (DUF4508) CCM2_C PF16545.5 ETN99362.1 - 8.7 6.9 10.4 23 5.6 0.0 4.8 4 3 1 5 5 5 0 Cerebral cavernous malformation protein, harmonin-homology SepSecS PF05889.13 ETN99363.1 - 2.4e-15 56.1 0.0 2.7e-15 55.9 0.0 1.0 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Peptidase_C23 PF05379.11 ETN99364.1 - 0.099 12.8 0.1 2.7 8.2 0.0 2.9 2 1 1 3 3 3 0 Carlavirus endopeptidase DUF4286 PF14114.6 ETN99365.1 - 0.019 15.4 1.5 2.6 8.6 0.4 3.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4286) DUF4379 PF14311.6 ETN99365.1 - 0.37 11.2 2.7 0.7 10.3 0.3 2.6 2 0 0 2 2 2 0 Probable Zinc-ribbon domain RecQ_Zn_bind PF16124.5 ETN99365.1 - 1.1 10.1 4.8 9.7 7.0 2.3 3.0 2 0 0 2 2 2 0 RecQ zinc-binding Presenilin PF01080.17 ETN99366.1 - 0.015 14.1 0.4 0.029 13.2 0.4 1.4 1 0 0 1 1 1 0 Presenilin RisS_PPD PF16524.5 ETN99366.1 - 0.064 13.5 0.9 0.33 11.2 0.2 2.3 2 0 0 2 2 2 0 Periplasmic domain of Sensor histidine kinase RisS HAD_2 PF13419.6 ETN99366.1 - 0.12 12.4 4.2 3.5 7.7 2.5 2.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase DUF4484 PF14831.6 ETN99366.1 - 0.39 10.7 5.1 0.15 12.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) FAM60A PF15396.6 ETN99366.1 - 3.7 7.5 9.4 0.99 9.4 0.9 2.3 2 0 0 2 2 2 0 Protein Family FAM60A Pkinase PF00069.25 ETN99367.1 - 2.2e-05 24.0 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain 2_5_RNA_ligase2 PF13563.6 ETN99368.1 - 5.3e-06 26.4 0.1 8.3e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily DUF1569 PF07606.11 ETN99368.1 - 0.021 14.8 0.1 0.38 10.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1569) CFEM PF05730.11 ETN99368.1 - 0.28 11.3 3.6 3.9 7.6 0.1 2.6 3 0 0 3 3 3 0 CFEM domain Mito_fiss_reg PF05308.11 ETN99369.1 - 0.0021 18.2 9.2 0.0027 17.8 9.2 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator Tfb4 PF03850.14 ETN99369.1 - 0.0038 16.8 3.1 0.0044 16.6 3.1 1.2 1 0 0 1 1 1 1 Transcription factor Tfb4 PPL5 PF18168.1 ETN99369.1 - 0.014 14.7 9.3 0.02 14.2 9.3 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Pox_Ag35 PF03286.14 ETN99369.1 - 0.15 11.9 17.9 0.093 12.5 16.4 1.4 1 1 0 1 1 1 0 Pox virus Ag35 surface protein HeLo PF14479.6 ETN99369.1 - 0.19 11.6 10.4 0.24 11.2 10.4 1.1 1 0 0 1 1 1 0 Prion-inhibition and propagation DUF935 PF06074.12 ETN99369.1 - 0.2 10.4 9.1 0.25 10.0 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF935) WDCP PF15390.6 ETN99369.1 - 0.24 9.8 10.7 0.29 9.5 10.7 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family CDC45 PF02724.14 ETN99369.1 - 0.25 9.6 16.9 0.32 9.2 16.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETN99369.1 - 0.38 9.5 9.8 0.4 9.4 9.8 1.2 1 0 0 1 1 1 0 Presenilin DUF1664 PF07889.12 ETN99369.1 - 0.41 10.7 6.6 0.64 10.1 6.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3573 PF12097.8 ETN99369.1 - 0.53 9.0 1.7 0.61 8.8 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) NARP1 PF12569.8 ETN99369.1 - 0.56 9.1 18.6 0.68 8.8 18.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Neur_chan_memb PF02932.16 ETN99369.1 - 0.83 9.7 14.1 1.2 9.1 14.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_11 PF13086.6 ETN99369.1 - 1.1 8.9 14.1 1.5 8.5 14.1 1.3 1 0 0 1 1 1 0 AAA domain SH3_13 PF18335.1 ETN99369.1 - 1.2 9.0 7.7 27 4.7 5.5 3.2 3 0 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain PIEZO PF15917.5 ETN99369.1 - 1.4 8.3 19.5 2 7.9 19.5 1.1 1 0 0 1 1 1 0 Piezo DUF913 PF06025.12 ETN99369.1 - 1.4 7.8 7.1 1.8 7.5 7.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Membralin PF09746.9 ETN99369.1 - 1.9 7.5 10.4 2 7.3 10.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein MDM10 PF12519.8 ETN99369.1 - 2.2 7.1 9.3 2.3 7.0 9.3 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 V_ATPase_I PF01496.19 ETN99369.1 - 2.5 5.9 11.7 3.3 5.5 11.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OATP PF03137.20 ETN99369.1 - 5 5.3 8.3 7 4.8 8.3 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family UPF0242 PF06785.11 ETN99369.1 - 5.7 7.0 22.4 8.9 6.4 22.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Zip PF02535.22 ETN99369.1 - 6.4 5.9 8.6 7.7 5.6 8.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 ETN99369.1 - 7 6.1 17.6 10 5.6 17.6 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 RRN3 PF05327.11 ETN99369.1 - 7.6 4.9 14.0 10 4.5 14.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 REV1_C PF16727.5 ETN99370.1 - 0.018 15.4 0.0 0.026 14.9 0.0 1.3 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain PNK3P PF08645.11 ETN99370.1 - 0.038 13.7 1.7 0.045 13.5 1.7 1.1 1 0 0 1 1 1 0 Polynucleotide kinase 3 phosphatase DHHA1 PF02272.19 ETN99370.1 - 0.22 12.0 4.0 0.28 11.6 4.0 1.1 1 0 0 1 1 1 0 DHHA1 domain Pkinase PF00069.25 ETN99372.1 - 1.5e-09 37.6 3.1 6e-09 35.6 0.5 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN99372.1 - 4.5e-06 26.1 1.2 9.2e-06 25.1 0.3 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Pyr_redox_2 PF07992.14 ETN99372.1 - 5.1e-06 25.9 0.0 8.9e-06 25.1 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase WD40 PF00400.32 ETN99373.1 - 1.1e-24 86.2 12.1 6.6e-06 26.8 0.4 5.5 4 2 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETN99373.1 - 2.3e-09 36.4 0.5 0.014 14.1 0.0 3.9 2 2 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99373.1 - 2.5e-09 37.3 0.1 0.0095 16.2 0.0 4.2 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN99373.1 - 0.00088 18.1 3.6 1.5 7.5 0.3 3.8 1 1 2 3 3 3 3 Nup133 N terminal like WD40_like PF17005.5 ETN99373.1 - 0.0083 15.5 0.9 2.1 7.6 0.0 3.2 1 1 2 4 4 4 2 WD40-like domain DUF1296 PF06972.11 ETN99374.1 - 0.029 14.5 0.0 0.053 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1296) WD40 PF00400.32 ETN99375.1 - 2.5e-22 78.7 18.3 1.1e-05 26.0 0.2 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99375.1 - 1.8e-09 37.8 0.1 0.0016 18.7 0.0 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99375.1 - 9.4e-07 27.8 2.2 0.05 12.2 0.0 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETN99375.1 - 0.00013 21.9 4.8 0.0005 20.0 3.3 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A zf-TRAF PF02176.18 ETN99376.1 - 3.7e-06 27.5 2.5 6.7e-06 26.7 2.5 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger YhdB PF14148.6 ETN99376.1 - 0.13 12.4 4.2 0.094 12.8 1.4 2.0 1 1 0 2 2 2 0 YhdB-like protein Ly49 PF08391.10 ETN99376.1 - 0.36 11.2 16.7 0.14 12.5 4.9 2.3 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region ABC_tran PF00005.27 ETN99376.1 - 0.87 10.1 5.2 1.3 9.6 5.2 1.3 1 0 0 1 1 1 0 ABC transporter FAM76 PF16046.5 ETN99376.1 - 4.5 6.6 16.3 12 5.1 16.2 1.7 1 1 0 1 1 1 0 FAM76 protein HEAT PF02985.22 ETN99377.1 - 2.1e-11 43.0 0.0 0.0029 17.7 0.0 5.9 6 0 0 6 6 6 2 HEAT repeat HEAT_2 PF13646.6 ETN99377.1 - 2.6e-08 34.1 0.0 0.09 13.2 0.0 5.1 3 2 3 6 6 6 2 HEAT repeats Cnd1 PF12717.7 ETN99377.1 - 0.0017 18.4 11.0 0.34 10.9 2.3 4.4 1 1 3 4 4 4 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETN99377.1 - 0.0078 16.7 0.0 20 5.8 0.0 4.5 7 1 0 7 7 7 1 HEAT-like repeat NLE PF08154.12 ETN99377.1 - 0.023 15.2 0.8 9.2 6.9 0.0 4.6 4 1 1 5 5 5 0 NLE (NUC135) domain MMS19_C PF12460.8 ETN99377.1 - 0.16 11.0 6.6 0.6 9.2 1.5 3.2 2 1 0 2 2 2 0 RNAPII transcription regulator C-terminal TAN PF11640.8 ETN99377.1 - 1.2 9.3 8.3 24 5.1 0.2 4.6 3 2 3 6 6 6 0 Telomere-length maintenance and DNA damage repair Baculo_11_kDa PF06143.11 ETN99378.1 - 2.2 7.9 6.8 2.8 7.6 0.8 2.5 3 0 0 3 3 3 0 Baculovirus 11 kDa family IMPa_helical PF18642.1 ETN99381.1 - 0.21 12.0 1.6 0.55 10.7 0.4 2.1 3 0 0 3 3 3 0 Immunomodulating metalloprotease helical domain RR_TM4-6 PF06459.12 ETN99382.1 - 2.3 8.0 16.8 2.5 7.9 16.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4775 PF16001.5 ETN99382.1 - 3.3 7.0 24.5 3.8 6.8 24.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Vfa1 PF08432.10 ETN99382.1 - 3.7 7.9 19.8 4.3 7.6 19.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Tim54 PF11711.8 ETN99382.1 - 5.3 5.7 12.8 6.6 5.4 12.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RabGAP-TBC PF00566.18 ETN99382.1 - 5.4 6.6 7.1 6.4 6.4 7.1 1.2 1 0 0 1 1 1 0 Rab-GTPase-TBC domain HEAT PF02985.22 ETN99384.1 - 9.6e-09 34.8 0.0 0.8 10.1 0.0 7.3 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 ETN99384.1 - 1.1e-08 35.3 0.0 0.015 15.7 0.0 5.3 3 1 2 5 5 5 2 HEAT repeats Cytochrom_C PF00034.21 ETN99384.1 - 0.00066 20.8 0.4 13 7.1 0.0 5.5 6 2 0 6 6 6 1 Cytochrome c RTP1_C1 PF10363.9 ETN99384.1 - 0.0014 18.8 19.4 0.59 10.3 0.1 6.1 3 3 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF3349 PF11829.8 ETN99384.1 - 0.0088 16.8 0.7 20 6.0 0.0 4.9 4 1 1 5 5 5 0 Protein of unknown function (DUF3349) HEAT_EZ PF13513.6 ETN99384.1 - 0.025 15.1 0.0 45 4.7 0.0 4.5 4 0 0 4 4 3 0 HEAT-like repeat BRCA-2_OB3 PF09104.10 ETN99384.1 - 0.029 14.0 1.8 8.9 6.0 0.0 4.5 5 0 0 5 5 5 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 DUF2459 PF09601.10 ETN99384.1 - 0.048 13.5 4.4 27 4.5 0.1 5.2 4 1 1 5 5 5 0 Protein of unknown function (DUF2459) BAF PF02961.14 ETN99384.1 - 0.16 12.4 2.6 4.8 7.7 0.1 4.4 3 0 0 3 3 3 0 Barrier to autointegration factor TPR_20 PF14561.6 ETN99384.1 - 0.21 11.9 5.8 3 8.2 0.0 5.1 3 1 3 6 6 6 0 Tetratricopeptide repeat Inhibitor_I9 PF05922.16 ETN99384.1 - 1.4 9.6 6.6 10 6.9 0.0 5.0 5 2 0 5 5 4 0 Peptidase inhibitor I9 Cnd1 PF12717.7 ETN99384.1 - 2.2 8.3 44.7 0.25 11.4 10.0 6.7 2 2 2 6 6 6 0 non-SMC mitotic condensation complex subunit 1 VraX PF17412.2 ETN99384.1 - 3 7.5 9.9 12 5.6 0.0 4.4 4 1 1 5 5 5 0 Family of unknown function Fe-S_assembly PF04384.13 ETN99384.1 - 3.8 8.2 9.1 1.1 9.9 0.1 4.7 6 0 0 6 6 5 0 Iron-sulphur cluster assembly NACHT PF05729.12 ETN99385.1 - 0.019 14.9 0.0 0.21 11.5 0.0 2.6 3 0 0 3 3 3 0 NACHT domain NLRC4_HD2 PF17776.1 ETN99385.1 - 0.021 15.4 11.2 0.062 13.8 0.1 4.2 3 1 0 3 3 3 0 NLRC4 helical domain HD2 Viral_DNA_Zn_bi PF03728.13 ETN99385.1 - 0.048 14.2 1.0 0.14 12.8 1.0 1.8 1 0 0 1 1 1 0 Viral DNA-binding protein, zinc binding domain DUF1086 PF06461.11 ETN99385.1 - 0.11 12.3 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) ABC_tran PF00005.27 ETN99389.1 - 0.00056 20.4 2.3 0.002 18.7 0.0 2.4 2 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ETN99389.1 - 0.0014 18.9 0.3 0.0068 16.7 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETN99389.1 - 0.0022 18.4 0.3 0.029 14.8 0.0 2.1 1 1 1 2 2 2 1 AAA ATPase domain AAA_7 PF12775.7 ETN99389.1 - 0.004 16.7 0.2 0.0082 15.7 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETN99389.1 - 0.0041 17.0 1.3 0.032 14.1 0.6 2.6 2 1 0 2 2 2 1 RsgA GTPase PduV-EutP PF10662.9 ETN99389.1 - 0.0082 15.9 0.0 0.019 14.7 0.0 1.6 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation DUF4811 PF16069.5 ETN99389.1 - 0.011 15.6 0.2 0.23 11.3 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4811) AAA PF00004.29 ETN99389.1 - 0.013 15.9 0.4 0.061 13.7 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 ETN99389.1 - 0.016 14.3 0.0 0.027 13.6 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain TsaE PF02367.17 ETN99389.1 - 0.026 14.5 0.0 0.058 13.4 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ETN99389.1 - 0.026 14.4 0.2 0.097 12.6 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Y_phosphatase PF00102.27 ETN99389.1 - 0.027 14.0 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein-tyrosine phosphatase DUF815 PF05673.13 ETN99389.1 - 0.032 13.4 0.5 0.093 11.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 ETN99389.1 - 0.035 14.1 0.0 0.072 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ETN99389.1 - 0.084 13.3 0.2 0.43 11.0 0.0 2.3 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 ETN99389.1 - 0.35 11.3 0.1 0.35 11.3 0.1 2.4 2 1 0 2 2 2 0 AAA domain GLTSCR1 PF15249.6 ETN99390.1 - 0.47 10.9 7.4 0.78 10.2 1.1 3.6 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein COG5 PF10392.9 ETN99390.1 - 0.5 10.5 9.5 0.023 14.8 1.7 2.8 3 0 0 3 3 3 0 Golgi transport complex subunit 5 MMR_HSR1 PF01926.23 ETN99392.1 - 0.0023 18.0 3.8 0.0031 17.6 0.5 2.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Spc7 PF08317.11 ETN99392.1 - 0.018 13.9 9.2 0.033 13.1 9.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein ABC_tran PF00005.27 ETN99392.1 - 0.049 14.1 2.2 0.089 13.3 0.0 2.3 2 0 0 2 2 2 0 ABC transporter NPL PF17800.1 ETN99392.1 - 0.15 12.7 3.4 0.11 13.1 1.4 1.8 2 0 0 2 2 2 0 Nucleoplasmin-like domain AAA_23 PF13476.6 ETN99392.1 - 0.34 11.4 9.4 12 6.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ETN99392.1 - 0.72 9.7 3.3 0.33 10.8 0.2 2.1 2 1 0 2 2 2 0 RsgA GTPase DUF4663 PF15668.5 ETN99393.1 - 0.1 11.7 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) YmaF PF12788.7 ETN99393.1 - 0.1 13.2 0.0 0.25 11.9 0.0 1.6 1 0 0 1 1 1 0 YmaF family MT PF12777.7 ETN99394.1 - 2.4e-10 40.0 11.0 3e-10 39.6 11.0 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Spc7 PF08317.11 ETN99394.1 - 0.0012 17.8 21.8 0.0015 17.5 21.8 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein UPF0489 PF12640.7 ETN99394.1 - 0.02 15.1 2.9 0.036 14.3 2.8 1.6 1 1 0 1 1 1 0 UPF0489 domain 30K_MP_C_Ter PF11330.8 ETN99394.1 - 0.033 13.5 2.1 0.039 13.3 0.9 1.6 1 1 1 2 2 2 0 C-Terminal of 30K viral movement proteins AAA_8 PF12780.7 ETN99394.1 - 0.045 13.1 0.1 0.045 13.1 0.1 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 DUF3673 PF12425.8 ETN99394.1 - 0.1 12.5 0.1 0.3 11.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3673) Nup88 PF10168.9 ETN99394.1 - 0.15 9.8 15.9 0.18 9.6 15.9 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF4200 PF13863.6 ETN99394.1 - 0.29 11.5 25.4 0.27 11.7 24.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Atg14 PF10186.9 ETN99394.1 - 0.31 10.1 8.2 0.42 9.6 8.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ALMT PF11744.8 ETN99394.1 - 0.67 8.7 9.8 0.81 8.4 9.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter ERM PF00769.19 ETN99394.1 - 0.71 9.6 26.4 1 9.2 26.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Borrelia_P83 PF05262.11 ETN99394.1 - 1.7 7.0 17.3 1.9 6.9 17.3 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF572 PF04502.13 ETN99394.1 - 2.5 7.7 13.0 2.8 7.5 13.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) V_ATPase_I PF01496.19 ETN99394.1 - 4.8 5.0 15.9 7.2 4.4 15.6 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family SwrA PF17423.2 ETN99395.1 - 0.11 12.5 3.1 0.23 11.5 0.9 2.7 2 0 0 2 2 2 0 Swarming motility protein Mad3_BUB1_I PF08311.12 ETN99395.1 - 0.69 9.9 5.1 0.43 10.6 0.6 2.9 2 1 1 3 3 3 0 Mad3/BUB1 homology region 1 CD34_antigen PF06365.12 ETN99396.1 - 0.0066 16.1 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 CD34/Podocalyxin family Ran-binding PF05508.11 ETN99396.1 - 0.16 10.9 1.5 6.5 5.6 0.1 2.8 3 0 0 3 3 3 0 RanGTP-binding protein DctQ PF04290.12 ETN99396.1 - 0.77 9.7 3.9 6.8 6.6 1.1 2.8 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF3948 PF13134.6 ETN99396.1 - 2.8 7.7 7.7 0.35 10.6 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3948) Rab5ip PF07019.12 ETN99396.1 - 8 7.1 15.5 10 6.8 0.3 4.5 4 0 0 4 4 4 0 Rab5-interacting protein (Rab5ip) WD40 PF00400.32 ETN99397.1 - 8.7e-95 308.1 39.0 1.5e-09 38.3 0.2 13.9 14 0 0 14 14 14 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99397.1 - 1e-25 89.8 16.2 0.0029 17.9 0.0 10.3 1 1 10 11 11 11 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99397.1 - 2e-19 69.8 14.9 0.034 13.1 0.1 10.3 2 1 6 9 9 9 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETN99397.1 - 4.5e-17 61.9 26.8 0.029 13.0 0.1 11.5 3 2 6 11 11 11 9 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99397.1 - 3.7e-10 39.6 9.4 0.03 13.6 0.1 5.8 3 2 3 6 6 6 3 WD40-like domain PD40 PF07676.12 ETN99397.1 - 1.6e-05 24.7 8.1 21 5.2 0.1 7.3 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETN99397.1 - 2.9e-05 22.8 6.0 0.23 10.0 0.1 4.4 3 2 1 4 4 4 2 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETN99397.1 - 3.2e-05 23.4 4.0 0.046 13.4 2.4 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) DUF5570 PF17731.1 ETN99397.1 - 4.5e-05 23.5 16.0 1.4 9.0 0.1 8.2 5 3 3 9 9 9 2 Family of unknown function (DUF5570) Ubiquitin_3 PF14836.6 ETN99397.1 - 0.024 14.6 0.3 14 5.7 0.0 4.8 2 1 2 5 5 5 0 Ubiquitin-like domain DUF1283 PF06932.11 ETN99397.1 - 0.15 12.2 0.6 1.3 9.3 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1283) Glycogen_syn PF05693.13 ETN99398.1 - 0.03 12.9 0.0 0.036 12.6 0.0 1.0 1 0 0 1 1 1 0 Glycogen synthase Lambda_Bor PF06291.11 ETN99399.1 - 0.11 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Bor protein WD40 PF00400.32 ETN99403.1 - 6.1e-67 219.9 24.7 3.5e-11 43.4 0.2 8.2 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99403.1 - 1.7e-25 89.1 2.7 0.00016 21.9 0.0 7.1 1 1 7 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99403.1 - 1.6e-21 76.6 3.9 0.0071 15.3 0.0 7.2 2 2 5 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN99403.1 - 2.1e-13 49.8 7.2 0.26 11.3 0.0 8.0 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETN99403.1 - 1.4e-08 34.5 0.1 0.1 11.9 0.0 3.9 2 2 2 4 4 4 4 WD40-like domain DUF727 PF05303.12 ETN99403.1 - 8.8e-07 29.0 0.7 4.5 7.4 0.0 6.1 2 2 5 7 7 7 1 Protein of unknown function (DUF727) DPPIV_N PF00930.21 ETN99403.1 - 1.2e-05 24.3 0.9 0.14 10.9 0.0 5.2 2 1 4 7 7 7 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nup160 PF11715.8 ETN99403.1 - 2.4e-05 23.2 7.3 0.62 8.6 0.0 4.8 1 1 1 5 5 5 2 Nucleoporin Nup120/160 Gmad1 PF10647.9 ETN99403.1 - 2.6e-05 24.1 0.0 8.1 6.1 0.0 5.3 1 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.6 ETN99403.1 - 0.00011 21.6 8.2 5.2 6.3 0.0 5.9 1 1 4 6 6 6 2 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETN99403.1 - 0.00012 21.3 0.4 0.11 11.6 0.1 2.7 1 1 2 3 3 3 2 Coatomer WD associated region PQQ_2 PF13360.6 ETN99403.1 - 0.00019 21.1 2.5 0.12 11.9 0.1 3.1 2 1 1 3 3 3 2 PQQ-like domain POLO_box PF00659.18 ETN99403.1 - 0.0024 18.1 1.7 2.5 8.3 0.0 5.0 2 2 3 5 5 5 1 POLO box duplicated region Proteasome_A_N PF10584.9 ETN99403.1 - 0.0036 16.9 15.7 5.5 6.8 0.1 6.7 6 0 0 6 6 6 1 Proteasome subunit A N-terminal signature Frtz PF11768.8 ETN99403.1 - 0.0048 15.3 0.0 4.8 5.4 0.0 3.4 2 1 2 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz Invas_SpaK PF03519.14 ETN99403.1 - 0.0064 16.5 0.5 0.026 14.6 0.5 2.2 1 0 0 1 1 1 1 Invasion protein B family DUF5570 PF17731.1 ETN99403.1 - 0.0067 16.5 11.8 3 8.0 0.0 5.7 1 1 4 5 5 5 1 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETN99403.1 - 0.0076 15.1 0.0 0.19 10.5 0.0 2.3 2 0 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) DUF5122 PF17164.4 ETN99403.1 - 0.018 15.3 0.2 8.1 6.8 0.0 4.6 6 0 0 6 6 5 0 Domain of unknown function (DUF5122) beta-propeller Big_7 PF17957.1 ETN99403.1 - 0.12 13.1 5.6 30 5.5 0.2 4.3 3 3 0 3 3 3 0 Bacterial Ig domain WD40 PF00400.32 ETN99404.1 - 6.9e-16 58.3 1.4 1.5e-08 35.1 0.0 4.9 3 1 1 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99404.1 - 1e-07 32.1 0.0 0.027 14.8 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETN99404.1 - 2.5e-06 27.5 0.3 0.0024 17.8 0.1 3.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETN99404.1 - 0.00037 20.4 0.3 1.3 9.0 0.0 2.8 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETN99404.1 - 0.0092 14.7 0.2 1.4 7.4 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETN99404.1 - 0.04 12.8 0.2 4 6.3 0.0 2.4 1 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain ABC_tran PF00005.27 ETN99406.1 - 0.0012 19.3 0.7 0.014 15.9 0.1 2.9 3 0 0 3 3 2 1 ABC transporter DUF815 PF05673.13 ETN99406.1 - 0.0027 16.9 0.0 0.0079 15.4 0.0 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ETN99406.1 - 0.0046 16.5 0.1 0.015 14.8 0.1 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETN99406.1 - 0.031 14.2 0.2 0.21 11.5 0.1 2.5 2 1 0 2 2 2 0 RsgA GTPase PduV-EutP PF10662.9 ETN99406.1 - 0.05 13.3 0.2 0.22 11.2 0.1 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 ETN99406.1 - 0.051 13.6 0.6 0.32 11.0 0.0 2.8 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ETN99406.1 - 0.072 13.4 3.0 22 5.4 0.1 3.7 3 0 0 3 3 3 0 AAA domain AAA PF00004.29 ETN99406.1 - 0.12 12.8 0.1 0.39 11.1 0.1 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETN99406.1 - 0.15 12.5 0.3 0.8 10.1 0.1 2.4 2 1 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETN99406.1 - 0.17 12.2 2.4 0.42 10.9 0.1 2.9 4 0 0 4 4 3 0 AAA domain HEPN_AbiA_CTD PF18732.1 ETN99406.1 - 1.6 8.7 5.8 6.7 6.6 1.3 2.9 2 0 0 2 2 2 0 HEPN like, Abia C-terminal domain Roc PF08477.13 ETN99406.1 - 5.8 7.2 6.4 9.4 6.5 0.1 3.9 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase BSP_II PF05432.11 ETN99407.1 - 0.002 17.9 21.9 0.0025 17.5 21.9 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 ETN99407.1 - 0.0032 17.0 18.8 0.0033 16.9 18.8 1.1 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 ETN99407.1 - 0.0037 16.7 18.9 0.0045 16.4 18.9 1.1 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 ETN99407.1 - 0.014 13.6 22.2 0.017 13.3 22.2 1.0 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETN99407.1 - 0.052 12.3 16.4 0.06 12.1 16.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2457 PF10446.9 ETN99407.1 - 0.079 12.1 23.1 0.094 11.8 23.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETN99407.1 - 0.19 10.0 18.4 0.22 9.8 18.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETN99407.1 - 0.2 9.7 25.8 0.26 9.4 25.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi CNDH2_C PF16858.5 ETN99407.1 - 0.3 10.9 16.1 0.41 10.5 16.1 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RR_TM4-6 PF06459.12 ETN99407.1 - 0.79 9.5 16.6 1.1 9.1 16.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 ETN99407.1 - 0.8 8.7 12.9 0.93 8.5 12.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Zip PF02535.22 ETN99407.1 - 1.1 8.4 9.1 1.3 8.2 9.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETN99407.1 - 1.4 7.6 14.8 1.7 7.3 14.8 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 ETN99407.1 - 2 8.4 11.6 2.5 8.0 11.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Vfa1 PF08432.10 ETN99407.1 - 2.1 8.7 22.4 3.1 8.1 22.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 ETN99407.1 - 2.2 7.2 13.3 2.8 6.9 13.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Smg8_Smg9 PF10220.9 ETN99407.1 - 2.7 6.2 12.1 3.3 5.9 12.1 1.0 1 0 0 1 1 1 0 Smg8_Smg9 DUF913 PF06025.12 ETN99407.1 - 5.4 5.9 10.2 7.2 5.5 10.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Hid1 PF12722.7 ETN99407.1 - 6.5 4.7 11.9 7.7 4.5 11.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.15 ETN99407.1 - 8.9 5.0 20.4 12 4.5 20.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 ETN99407.1 - 9 6.3 7.1 12 5.9 7.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AAA_11 PF13086.6 ETN99407.1 - 9.8 5.9 13.5 14 5.4 13.5 1.1 1 0 0 1 1 1 0 AAA domain zf-MYND PF01753.18 ETN99408.1 - 4.9e-09 36.1 4.7 1.4e-08 34.7 4.6 1.9 1 1 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 ETN99408.1 - 1.7e-05 24.8 6.1 1.7e-05 24.8 6.1 2.0 2 1 0 2 2 2 1 Zinc-finger of mitochondrial splicing suppressor 51 FAM222A PF15258.6 ETN99408.1 - 0.018 14.2 12.8 0.022 13.9 12.8 1.3 1 0 0 1 1 1 0 Protein family of FAM222A Pex14_N PF04695.13 ETN99408.1 - 0.8 10.3 15.1 1.4 9.5 15.1 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 ETN99408.1 - 1.2 7.8 2.7 1.3 7.8 2.7 1.1 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETN99409.1 - 1.3e-82 269.6 35.5 3.7e-09 37.1 0.2 11.1 12 0 0 12 12 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99409.1 - 5.2e-23 81.2 7.3 0.012 15.9 0.0 9.0 1 1 8 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99409.1 - 4.9e-12 45.5 1.6 0.91 8.4 0.0 7.4 1 1 7 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN99409.1 - 2.2e-11 43.6 7.1 0.00076 18.9 0.2 5.2 2 2 2 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETN99409.1 - 2.4e-07 29.8 14.7 2.2 6.8 0.0 8.2 1 1 6 8 8 8 3 Nucleoporin Nup120/160 DUF5046 PF16465.5 ETN99409.1 - 1.6e-06 27.7 0.0 0.053 13.0 0.0 3.3 2 1 1 3 3 3 2 Domain of unknown function (DUF5046) DUF5570 PF17731.1 ETN99409.1 - 7.7e-06 26.0 6.9 1.9 8.6 0.0 6.2 2 2 3 6 6 6 1 Family of unknown function (DUF5570) Frtz PF11768.8 ETN99409.1 - 1.8e-05 23.3 0.5 0.6 8.4 0.0 3.3 2 1 0 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETN99409.1 - 1.9e-05 24.5 2.7 5.2 7.1 0.0 5.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETN99409.1 - 6.2e-05 21.7 2.4 0.6 8.6 0.1 3.5 2 1 1 3 3 3 3 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETN99409.1 - 0.012 14.6 4.4 0.43 9.4 0.1 4.0 3 3 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Senescence PF06911.12 ETN99410.1 - 9.4e-09 35.8 4.2 1.2e-08 35.4 4.2 1.1 1 0 0 1 1 1 1 Senescence-associated protein DUF4775 PF16001.5 ETN99411.1 - 0.43 10.0 11.7 0.52 9.7 11.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) DUF641 PF04859.12 ETN99411.1 - 1.2 9.5 9.5 3.1 8.2 9.4 1.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) zf-C3HC4_3 PF13920.6 ETN99412.1 - 3.3e-08 33.3 10.3 3.3e-08 33.3 10.3 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETN99412.1 - 0.00012 21.8 7.8 0.00025 20.8 7.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 MBT PF02820.18 ETN99412.1 - 0.0011 19.3 1.3 0.1 13.0 0.0 3.2 3 0 0 3 3 3 1 mbt repeat SAM_1 PF00536.30 ETN99412.1 - 0.0017 18.8 0.5 0.0077 16.6 0.5 2.3 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SLT_2 PF13406.6 ETN99412.1 - 0.11 11.7 0.3 0.22 10.7 0.3 1.4 1 0 0 1 1 1 0 Transglycosylase SLT domain Tudor-knot PF11717.8 ETN99412.1 - 0.15 11.9 2.8 0.23 11.4 0.2 2.8 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain DUF3330 PF11809.8 ETN99412.1 - 1.1 9.4 4.2 2.7 8.1 4.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3330) HEAT PF02985.22 ETN99413.1 - 1e-26 90.7 1.1 0.0065 16.6 0.0 9.7 11 0 0 11 11 9 5 HEAT repeat HEAT_2 PF13646.6 ETN99413.1 - 1.8e-15 57.1 0.0 2.1e-06 28.0 0.0 5.6 3 1 4 7 7 7 4 HEAT repeats Vac14_Fab1_bd PF12755.7 ETN99413.1 - 2.9e-11 43.8 10.6 0.0082 16.7 0.2 6.8 4 2 3 7 7 7 3 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ETN99413.1 - 1.8e-08 34.7 0.0 0.97 10.0 0.0 4.9 3 1 1 4 4 4 2 HEAT-like repeat Ank_3 PF13606.6 ETN99413.1 - 4.4e-08 32.8 0.2 0.00083 19.6 0.0 4.1 4 0 0 4 4 3 2 Ankyrin repeat Cnd1 PF12717.7 ETN99413.1 - 4.6e-08 33.3 28.1 1.7e-05 24.9 2.4 6.3 2 1 4 6 6 6 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETN99413.1 - 1.1e-07 32.0 3.1 0.13 12.4 0.0 5.0 2 1 2 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Ank_2 PF12796.7 ETN99413.1 - 5.7e-07 30.0 0.3 1.4e-05 25.6 0.0 3.4 4 0 0 4 4 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETN99413.1 - 3.9e-06 27.0 0.1 2e-05 24.8 0.1 2.3 2 0 0 2 2 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETN99413.1 - 0.0014 19.1 0.4 0.049 14.2 0.1 3.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETN99413.1 - 0.0032 17.9 0.0 0.036 14.5 0.0 3.0 2 0 0 2 2 1 1 Ankyrin repeat DUF3349 PF11829.8 ETN99413.1 - 0.0064 17.2 5.9 37 5.2 0.4 6.4 3 1 3 7 7 7 0 Protein of unknown function (DUF3349) DNA_pol3_gamma3 PF12169.8 ETN99413.1 - 0.03 14.2 0.0 9.1 6.2 0.0 3.8 2 2 3 5 5 5 0 DNA polymerase III subunits gamma and tau domain III Cache_3-Cache_2 PF17201.4 ETN99413.1 - 0.071 12.4 1.3 5 6.3 0.2 2.5 1 1 0 2 2 2 0 Cache 3/Cache 2 fusion domain Sacchrp_dh_NADP PF03435.18 ETN99413.1 - 0.1 12.9 0.0 0.5 10.6 0.0 2.2 2 0 0 2 2 1 0 Saccharopine dehydrogenase NADP binding domain RsfS PF02410.15 ETN99413.1 - 0.46 10.9 4.0 55 4.3 3.9 3.8 1 1 0 1 1 1 0 Ribosomal silencing factor during starvation MOR2-PAG1_C PF14225.6 ETN99413.1 - 0.59 9.9 7.6 1.3 8.9 0.2 3.4 2 1 2 4 4 3 0 Cell morphogenesis C-terminal Arm-DNA-bind_2 PF12167.8 ETN99413.1 - 0.86 9.6 2.5 24 4.9 0.0 4.2 5 0 0 5 5 5 0 Arm DNA-binding domain CCDC24 PF15669.5 ETN99413.1 - 1 9.2 5.1 4.2 7.2 0.4 3.4 2 2 2 4 4 4 0 Coiled-coil domain-containing protein 24 family Syntaphilin PF15290.6 ETN99413.1 - 1.1 8.9 10.2 18 4.9 0.5 3.4 1 1 2 3 3 3 0 Golgi-localised syntaxin-1-binding clamp CCDC-167 PF15188.6 ETN99413.1 - 1.1 9.7 13.2 15 6.0 1.0 4.7 3 1 1 5 5 3 0 Coiled-coil domain-containing protein 167 Spore_III_AB PF09548.10 ETN99413.1 - 8.9 6.4 13.6 5.6 7.0 0.8 3.9 2 2 3 5 5 5 0 Stage III sporulation protein AB (spore_III_AB) Pet20 PF08692.10 ETN99414.1 - 0.045 14.5 1.0 0.084 13.6 0.0 1.9 2 1 0 2 2 2 0 Mitochondrial protein Pet20 RNase_H PF00075.24 ETN99415.1 - 3.5e-17 62.9 0.0 9.7e-17 61.5 0.0 1.8 1 0 0 1 1 1 1 RNase H RVT_1 PF00078.27 ETN99415.1 - 9e-07 28.6 0.7 4.2e-06 26.4 0.1 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RVT_3 PF13456.6 ETN99415.1 - 0.016 15.1 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like CMAS PF02353.20 ETN99415.1 - 0.033 13.5 0.0 0.073 12.4 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Herpes_TK_C PF08465.10 ETN99415.1 - 0.088 12.6 0.1 0.23 11.2 0.1 1.7 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal PI_PP_I PF18363.1 ETN99415.1 - 5.8 7.2 7.3 4.1 7.6 0.1 3.2 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain DUF1421 PF07223.11 ETN99416.1 - 0.003 17.3 0.1 0.0048 16.7 0.1 1.3 1 0 0 1 1 1 1 UBA-like domain (DUF1421) ERAP1_C PF11838.8 ETN99417.1 - 1.8e-11 44.2 0.1 3.5e-11 43.2 0.1 1.5 2 0 0 2 2 2 1 ERAP1-like C-terminal domain TPR_12 PF13424.6 ETN99418.1 - 2.5e-18 66.1 1.5 6e-10 39.3 0.2 2.3 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99418.1 - 4.3e-14 51.8 0.5 1.2e-05 25.0 0.4 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99418.1 - 1.7e-13 49.8 12.2 6.7e-07 28.9 0.5 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99418.1 - 1.4e-12 46.6 1.2 5.9e-05 22.8 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99418.1 - 7.9e-10 38.2 10.4 4.9e-05 23.2 0.4 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99418.1 - 9.7e-10 37.8 7.8 0.00015 21.6 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat SNAP PF14938.6 ETN99418.1 - 0.00032 20.2 1.7 0.00033 20.2 1.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETN99418.1 - 0.00034 20.8 2.0 0.0083 16.4 0.6 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99418.1 - 0.00061 20.4 0.0 1.4 9.6 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat Phage_Treg PF04761.12 ETN99418.1 - 0.0036 17.4 1.7 0.024 14.7 0.1 2.2 2 0 0 2 2 2 1 Lactococcus bacteriophage putative transcription regulator ANAPC3 PF12895.7 ETN99418.1 - 0.0039 17.4 4.1 0.01 16.1 1.9 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETN99418.1 - 0.0048 16.6 14.3 0.064 12.9 0.6 3.6 3 1 1 4 4 4 2 TPR repeat TPR_6 PF13174.6 ETN99418.1 - 0.011 16.3 0.2 3 8.7 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETN99418.1 - 0.019 14.8 4.7 0.36 10.6 2.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) HTH_Bact PF18768.1 ETN99418.1 - 0.027 14.1 6.6 3.1 7.4 0.4 3.8 2 1 2 4 4 4 0 Helix-turn-helix bacterial domain TPR_MalT PF17874.1 ETN99418.1 - 0.041 13.3 0.0 0.044 13.1 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region ox_reductase_C PF08635.10 ETN99418.1 - 0.046 13.4 0.2 0.054 13.2 0.2 1.1 1 0 0 1 1 1 0 Putative oxidoreductase C terminal domain zf-TRAF PF02176.18 ETN99420.1 - 5e-06 27.1 1.9 5e-06 27.1 1.9 2.4 2 1 0 2 2 2 1 TRAF-type zinc finger Sina PF03145.16 ETN99420.1 - 0.0049 16.8 6.4 0.017 15.0 6.3 1.9 1 1 0 1 1 1 1 Seven in absentia protein family CCDC50_N PF15295.6 ETN99420.1 - 0.022 14.9 0.4 0.041 14.0 0.4 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus OrsD PF12013.8 ETN99420.1 - 0.04 14.3 2.2 0.081 13.4 0.7 2.1 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D CENP-N PF05238.13 ETN99420.1 - 0.046 13.0 0.3 0.07 12.4 0.3 1.2 1 0 0 1 1 1 0 Kinetochore protein CHL4 like CDO_I PF05995.12 ETN99420.1 - 0.063 12.6 0.2 0.12 11.6 0.1 1.5 1 1 1 2 2 2 0 Cysteine dioxygenase type I Aa_trans PF01490.18 ETN99421.1 - 1.1e-19 70.5 0.3 1.4e-19 70.1 0.3 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein EI24 PF07264.11 ETN99421.1 - 3e-05 24.4 1.4 7.9e-05 23.0 1.4 1.7 1 1 0 1 1 1 1 Etoposide-induced protein 2.4 (EI24) cNMP_binding PF00027.29 ETN99423.1 - 7e-09 35.7 0.0 7.7e-07 29.1 0.0 2.3 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DUF4835 PF16119.5 ETN99424.1 - 0.0012 18.0 0.9 0.0021 17.2 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4835) BOF PF04076.13 ETN99424.1 - 0.018 15.1 0.4 0.037 14.1 0.4 1.4 1 1 0 1 1 1 0 Bacterial OB fold (BOF) protein DUF4958 PF16319.5 ETN99425.1 - 0.00073 17.7 3.5 0.00092 17.3 3.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4958) DUF445 PF04286.12 ETN99425.1 - 0.0092 15.8 0.3 0.02 14.7 0.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF445) Imm70 PF15601.6 ETN99425.1 - 0.01 15.4 0.4 12 5.5 0.0 3.8 2 1 1 4 4 4 0 Immunity protein 70 TIP120 PF08623.10 ETN99425.1 - 0.034 13.9 1.9 0.14 12.0 0.4 2.4 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) DUF2543 PF10820.8 ETN99425.1 - 0.065 13.4 0.5 0.27 11.4 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2543) DUF4508 PF14969.6 ETN99425.1 - 0.21 11.9 2.3 8.9 6.7 0.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4508) RPN2_C PF18004.1 ETN99426.1 - 0.33 10.9 3.2 0.35 10.8 3.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cwf_Cwc_15 PF04889.12 ETN99426.1 - 1.2 8.8 19.3 1.4 8.6 19.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Mpp10 PF04006.12 ETN99426.1 - 8.2 4.7 22.9 9.6 4.5 22.9 1.0 1 0 0 1 1 1 0 Mpp10 protein TRAP_alpha PF03896.16 ETN99426.1 - 8.6 5.5 10.4 9.2 5.4 10.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit WD40 PF00400.32 ETN99427.1 - 5.4e-24 84.0 3.0 1.4e-11 44.7 0.1 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99427.1 - 4.3e-11 43.0 0.0 6.2e-05 23.2 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide PF00805.22 ETN99427.1 - 1.2e-07 31.2 7.6 6e-05 22.6 2.0 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) WD40_like PF17005.5 ETN99427.1 - 3.5e-05 23.3 0.1 0.0001 21.8 0.0 1.7 2 0 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETN99427.1 - 0.00015 21.7 0.0 0.00037 20.4 0.0 1.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Pentapeptide_4 PF13599.6 ETN99427.1 - 0.00054 20.1 0.2 0.001 19.2 0.2 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Ge1_WD40 PF16529.5 ETN99427.1 - 0.0015 17.5 0.0 0.85 8.5 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN99427.1 - 0.015 15.2 0.1 5.3 7.1 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETN99427.1 - 0.022 14.3 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 PQQ-like domain Nbas_N PF15492.6 ETN99427.1 - 0.038 13.3 0.1 1 8.6 0.0 2.0 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETN99427.1 - 0.04 14.0 0.5 10 6.2 0.1 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5570) Frtz PF11768.8 ETN99427.1 - 0.045 12.1 0.0 2.3 6.4 0.0 2.0 1 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Pentapeptide_3 PF13576.6 ETN99427.1 - 0.047 13.9 0.8 0.047 13.9 0.8 2.0 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) Proteasome_A_N PF10584.9 ETN99427.1 - 0.16 11.7 0.9 20 4.9 0.1 2.6 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature APG12 PF04110.13 ETN99429.1 - 0.14 12.6 0.4 3.9 8.0 0.2 2.4 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 PT PF04886.12 ETN99429.1 - 0.36 10.4 21.0 0.55 9.8 4.3 3.0 2 1 0 2 2 2 0 PT repeat DUF2572 PF10833.8 ETN99430.1 - 0.13 12.0 2.5 0.14 11.9 2.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2572) DUF3959 PF13105.6 ETN99430.1 - 7 6.1 7.0 8.2 5.9 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) zf-RanBP PF00641.18 ETN99431.1 - 7.3e-07 28.4 1.4 1.4e-06 27.5 1.4 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Paf1 PF03985.13 ETN99431.1 - 0.055 12.5 3.8 0.088 11.8 3.8 1.3 1 0 0 1 1 1 0 Paf1 HEAT PF02985.22 ETN99432.1 - 0.01 16.0 0.0 5.5 7.5 0.0 3.6 3 0 0 3 3 3 0 HEAT repeat C1_2 PF03107.16 ETN99433.1 - 0.00054 20.2 1.8 0.0012 19.1 1.8 1.7 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 ETN99433.1 - 0.0034 17.2 5.8 0.0075 16.1 5.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) CDC27 PF09507.10 ETN99433.1 - 0.014 14.8 15.4 0.016 14.7 15.4 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Prok-RING_1 PF14446.6 ETN99433.1 - 0.022 14.7 4.1 0.022 14.7 4.1 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 ETN99433.1 - 0.023 14.6 5.4 0.074 13.0 5.4 1.9 1 0 0 1 1 1 0 PHD-finger CAC1F_C PF16885.5 ETN99433.1 - 2.1 8.0 11.6 2.7 7.6 11.6 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term TPR_12 PF13424.6 ETN99434.1 - 2.8e-40 136.5 2.2 3.8e-17 62.4 0.0 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99434.1 - 6.9e-21 73.4 0.0 1.3e-07 31.2 0.0 3.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99434.1 - 6.1e-20 70.1 12.8 6.1e-09 35.3 0.6 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99434.1 - 1.9e-19 68.2 0.1 5.3e-06 26.1 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99434.1 - 1.1e-14 53.3 13.2 1.1e-05 25.3 0.2 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99434.1 - 1.7e-12 46.4 5.1 0.00024 21.0 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99434.1 - 3.7e-06 26.9 7.2 0.0071 16.7 0.2 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99434.1 - 6.7e-06 25.7 17.0 0.029 14.1 1.1 4.5 4 2 1 5 5 5 3 TPR repeat DUF5113 PF17140.4 ETN99434.1 - 5.4e-05 23.1 1.8 0.062 13.1 0.1 2.8 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) DUF4810 PF16068.5 ETN99434.1 - 0.0011 19.4 0.1 2.3 8.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4810) TPR_6 PF13174.6 ETN99434.1 - 0.0026 18.3 0.1 1.2 9.9 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETN99434.1 - 0.0034 17.1 1.3 0.006 16.3 1.4 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) SNAP PF14938.6 ETN99434.1 - 0.0091 15.5 0.1 0.011 15.1 0.1 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP EST1_DNA_bind PF10373.9 ETN99434.1 - 0.013 15.0 0.1 0.045 13.2 0.1 1.9 1 1 1 2 2 2 0 Est1 DNA/RNA binding domain HTH_Bact PF18768.1 ETN99434.1 - 0.014 15.0 0.1 20 4.9 0.0 3.3 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain MIT PF04212.18 ETN99434.1 - 0.015 15.4 2.5 0.21 11.6 0.2 2.8 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 ETN99434.1 - 0.025 15.2 0.0 3.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99434.1 - 0.025 15.4 0.0 2.2 9.3 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 ETN99434.1 - 0.033 14.4 1.6 4.1 7.9 0.0 3.0 3 0 0 3 3 3 0 PPR repeat YecM PF06185.12 ETN99434.1 - 0.064 12.9 0.3 11 5.6 0.1 2.4 1 1 0 2 2 2 0 YecM protein TPR_3 PF07720.12 ETN99434.1 - 0.077 13.0 2.0 0.33 11.0 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF627 PF04781.12 ETN99434.1 - 0.091 12.8 0.1 0.18 11.9 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF627) Mob_Pre PF01076.19 ETN99434.1 - 0.1 12.4 1.3 0.12 12.2 0.6 1.6 1 1 1 2 2 2 0 Plasmid recombination enzyme SPO22 PF08631.10 ETN99434.1 - 0.13 11.7 1.0 0.79 9.2 0.8 1.9 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like Cys_rich_KTR PF14205.6 ETN99435.1 - 0.044 13.6 0.1 0.12 12.2 0.1 1.7 1 0 0 1 1 1 0 Cysteine-rich KTR HigB_toxin PF09907.9 ETN99436.1 - 0.012 15.8 0.1 0.021 15.1 0.1 1.4 1 0 0 1 1 1 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system NACHT PF05729.12 ETN99437.1 - 2.4e-18 66.6 0.0 6e-18 65.3 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 ETN99437.1 - 0.1 13.2 0.0 0.1 13.2 0.0 4.3 5 1 0 5 5 5 0 NLRC4 helical domain HD2 TPR_12 PF13424.6 ETN99438.1 - 2.4e-12 47.0 0.0 1.4e-10 41.3 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99438.1 - 2.4e-11 42.9 0.6 1.4e-07 31.0 0.2 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99438.1 - 9.6e-09 34.7 0.2 1.7e-06 27.7 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99438.1 - 9.7e-09 34.8 2.7 8e-07 28.8 0.5 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99438.1 - 9.5e-07 28.4 0.0 5.8e-05 22.8 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99438.1 - 1.5e-06 27.9 0.0 0.00037 20.3 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99438.1 - 0.00098 18.8 2.2 0.009 15.7 0.4 2.3 2 1 0 2 2 2 1 TPR repeat MIT PF04212.18 ETN99438.1 - 0.0011 19.0 0.9 0.014 15.5 0.2 2.0 1 1 1 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETN99438.1 - 0.0021 18.3 0.7 0.11 13.0 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99438.1 - 0.0092 16.7 0.0 0.071 14.0 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETN99438.1 - 0.015 15.9 0.8 0.16 12.6 0.2 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Vta1_C PF18097.1 ETN99438.1 - 0.13 12.0 1.2 13 5.6 0.0 2.4 2 1 0 2 2 2 0 Vta1 C-terminal domain TPR_3 PF07720.12 ETN99438.1 - 1.1 9.3 3.8 0.68 10.0 0.4 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat UCH PF00443.29 ETN99439.1 - 9.8e-07 28.5 0.0 4.1e-06 26.5 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETN99439.1 - 0.0087 15.7 0.6 0.03 13.9 0.5 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SPARC_Ca_bdg PF10591.9 ETN99441.1 - 0.03 14.6 0.4 0.03 14.6 0.4 3.4 3 1 1 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region DUF3439 PF11921.8 ETN99441.1 - 1.1 9.2 9.1 2.6 8.0 9.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rtf2 PF04641.12 ETN99442.1 - 5.9 6.2 21.3 8.2 5.7 13.5 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Fibrinogen_C PF00147.18 ETN99444.1 - 0.0042 16.9 0.0 0.0099 15.7 0.0 1.6 2 0 0 2 2 2 1 Fibrinogen beta and gamma chains, C-terminal globular domain DUF4145 PF13643.6 ETN99444.1 - 0.079 13.1 0.4 0.21 11.7 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) TolB_like PF15869.5 ETN99444.1 - 0.08 12.2 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 TolB-like 6-blade propeller-like WD40 PF00400.32 ETN99445.1 - 1.1e-44 149.4 9.7 3.5e-11 43.4 0.1 5.0 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99445.1 - 1.4e-19 70.2 0.0 1.2e-05 25.5 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99445.1 - 5.5e-14 52.2 0.5 6.6e-05 22.4 0.0 3.5 1 1 3 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETN99445.1 - 5.2e-07 28.9 0.1 0.29 10.0 0.0 3.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETN99445.1 - 4.4e-05 23.6 3.4 0.044 13.9 0.4 3.6 1 1 3 4 4 4 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETN99445.1 - 6e-05 22.7 0.2 0.076 12.6 0.0 2.6 1 1 0 2 2 2 2 PQQ-like domain PD40 PF07676.12 ETN99445.1 - 0.00011 22.1 6.1 7 6.7 0.1 4.9 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat DUF727 PF05303.12 ETN99445.1 - 0.00012 22.1 0.0 3.1 7.9 0.0 3.9 1 1 3 4 4 4 2 Protein of unknown function (DUF727) Nup160 PF11715.8 ETN99445.1 - 0.00014 20.7 0.0 7.8 5.0 0.0 3.9 2 1 2 4 4 4 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETN99445.1 - 0.00031 20.2 1.4 0.41 9.9 0.1 3.1 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Big_7 PF17957.1 ETN99445.1 - 0.0023 18.7 1.1 15 6.4 0.3 4.0 3 1 0 3 3 3 0 Bacterial Ig domain Cytochrom_D1 PF02239.16 ETN99445.1 - 0.0059 15.2 0.1 0.078 11.5 0.1 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain NYD-SP28_assoc PF14775.6 ETN99445.1 - 0.024 14.8 0.0 75 3.5 0.0 3.9 4 0 0 4 4 4 0 Sperm tail C-terminal domain Proteasome_A_N PF10584.9 ETN99445.1 - 0.025 14.3 2.9 30 4.4 0.1 4.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Gmad1 PF10647.9 ETN99445.1 - 0.036 13.8 0.0 0.68 9.6 0.0 2.9 1 1 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain PQQ PF01011.21 ETN99445.1 - 0.093 12.7 0.0 82 3.4 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat 3-dmu-9_3-mt PF06983.13 ETN99445.1 - 0.11 13.0 0.1 18 5.9 0.0 3.4 1 1 3 4 4 4 0 3-demethylubiquinone-9 3-methyltransferase RE_XamI PF09572.10 ETN99445.1 - 0.17 11.6 0.0 21 4.7 0.0 3.2 1 1 3 4 4 4 0 XamI restriction endonuclease CSN4_RPN5_eIF3a PF18420.1 ETN99445.1 - 1.1 9.5 7.7 65 3.8 0.1 4.0 4 0 0 4 4 4 0 CSN4/RPN5/eIF3a helix turn helix domain NUC173 PF08161.12 ETN99447.1 - 0.011 15.4 0.1 0.039 13.6 0.1 1.8 1 1 1 2 2 2 0 NUC173 domain Ripply PF14998.6 ETN99449.1 - 0.086 13.5 0.1 0.2 12.3 0.1 1.6 1 0 0 1 1 1 0 Transcription Regulator Kelch_4 PF13418.6 ETN99450.1 - 1.3e-07 31.5 0.0 3.6e-07 30.1 0.0 1.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99450.1 - 1.1e-06 28.1 0.4 2.6e-05 23.7 0.1 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETN99450.1 - 2.4e-05 24.4 0.2 0.0017 18.6 0.1 3.0 2 1 1 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETN99450.1 - 0.00042 20.2 0.6 0.014 15.3 0.4 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETN99450.1 - 0.016 15.5 0.0 0.093 13.0 0.0 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain U-box PF04564.15 ETN99451.1 - 1.7e-11 44.1 0.1 4.5e-11 42.8 0.1 1.7 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETN99451.1 - 0.027 14.6 0.0 0.045 13.9 0.0 1.5 1 1 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein SAM_3 PF18016.1 ETN99451.1 - 0.089 12.6 0.1 0.23 11.3 0.1 1.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) UPRTase PF14681.6 ETN99451.1 - 0.17 11.3 0.0 0.18 11.2 0.0 1.1 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase DUF4720 PF15846.5 ETN99452.1 - 0.029 14.2 0.0 0.039 13.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4720) DUF4152 PF13680.6 ETN99453.1 - 0.019 14.4 1.6 0.71 9.3 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4152) DUF1477 PF07346.11 ETN99453.1 - 0.068 13.4 1.4 0.71 10.1 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1477) L27_1 PF09058.10 ETN99454.1 - 0.18 11.8 0.4 2.2 8.3 0.0 2.3 2 0 0 2 2 2 0 L27_1 BRK PF07533.16 ETN99455.1 - 0.0077 15.8 0.4 0.014 15.0 0.4 1.4 1 0 0 1 1 1 1 BRK domain TPR_11 PF13414.6 ETN99455.1 - 0.039 13.6 0.2 0.039 13.6 0.2 1.7 2 0 0 2 2 2 0 TPR repeat ANAPC4 PF12896.7 ETN99455.1 - 0.064 12.8 3.0 0.77 9.2 0.5 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 4 YgaB PF14182.6 ETN99455.1 - 0.074 13.5 0.5 0.074 13.5 0.5 2.9 3 0 0 3 3 3 0 YgaB-like protein TPR_14 PF13428.6 ETN99455.1 - 0.086 13.7 0.1 6.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF948 PF06103.11 ETN99455.1 - 0.15 12.3 0.1 0.15 12.3 0.1 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CENP-B_dimeris PF09026.10 ETN99455.1 - 0.15 12.4 6.9 0.34 11.3 6.9 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TPR_2 PF07719.17 ETN99455.1 - 0.2 11.9 1.8 24 5.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2031 PF09592.10 ETN99455.1 - 0.9 9.0 11.1 2.2 7.7 11.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2031) AAA_11 PF13086.6 ETN99455.1 - 7.2 6.3 11.6 6.3 6.5 8.8 1.9 2 0 0 2 2 2 0 AAA domain HEAT PF02985.22 ETN99456.1 - 4.6e-18 63.8 4.5 0.0027 17.8 0.0 9.3 9 0 0 9 9 8 4 HEAT repeat HEAT_2 PF13646.6 ETN99456.1 - 5.2e-17 62.0 0.0 2.4e-07 31.0 0.0 6.4 4 2 3 7 7 7 5 HEAT repeats HEAT_EZ PF13513.6 ETN99456.1 - 9.3e-11 42.0 0.0 0.00063 20.2 0.0 6.6 7 1 1 8 8 7 3 HEAT-like repeat Ank_3 PF13606.6 ETN99456.1 - 2e-06 27.7 0.4 0.0033 17.8 0.1 3.8 3 0 0 3 3 2 1 Ankyrin repeat Vac14_Fab1_bd PF12755.7 ETN99456.1 - 2.6e-06 28.0 12.8 0.29 11.8 0.0 6.0 5 1 1 6 6 5 2 Vacuolar 14 Fab1-binding region Ank_2 PF12796.7 ETN99456.1 - 4.6e-06 27.1 0.4 3.7e-05 24.2 0.0 2.9 3 0 0 3 3 1 1 Ankyrin repeats (3 copies) Cnd1 PF12717.7 ETN99456.1 - 4e-05 23.7 24.2 0.0028 17.7 1.6 5.5 2 1 3 6 6 6 2 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETN99456.1 - 5.1e-05 23.1 14.5 0.032 14.0 0.2 5.2 3 1 2 5 5 5 2 TATA-binding protein interacting (TIP20) Ank_4 PF13637.6 ETN99456.1 - 0.00017 22.1 0.2 0.00095 19.7 0.2 2.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) CLASP_N PF12348.8 ETN99456.1 - 0.00034 20.2 0.5 0.00034 20.2 0.5 3.4 3 1 0 3 3 3 1 CLASP N terminal Ank_5 PF13857.6 ETN99456.1 - 0.00081 19.6 0.1 0.0031 17.8 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) UN_NPL4 PF11543.8 ETN99456.1 - 0.0058 17.1 0.1 0.026 15.0 0.0 2.1 2 0 0 2 2 1 1 Nuclear pore localisation protein NPL4 Ank PF00023.30 ETN99456.1 - 0.0062 16.9 0.7 0.077 13.5 0.0 3.3 4 0 0 4 4 2 1 Ankyrin repeat Symplekin_C PF12295.8 ETN99456.1 - 0.027 14.6 3.4 3.9 7.5 0.0 4.0 3 0 0 3 3 3 0 Symplekin tight junction protein C terminal DUF2555 PF10742.9 ETN99456.1 - 0.052 13.4 0.1 37 4.3 0.0 4.8 4 0 0 4 4 4 0 Protein of unknown function (DUF2555) HEAT_PBS PF03130.16 ETN99456.1 - 0.054 14.2 0.0 1.5e+02 3.5 0.0 5.2 4 1 0 4 4 4 0 PBS lyase HEAT-like repeat DnaG_DnaB_bind PF08278.11 ETN99456.1 - 0.055 14.1 3.3 4.1 8.0 0.1 5.0 6 0 0 6 6 5 0 DNA primase DnaG DnaB-binding DUF3349 PF11829.8 ETN99456.1 - 0.15 12.8 7.8 31 5.4 0.0 6.1 3 1 4 7 7 7 0 Protein of unknown function (DUF3349) DUF5071 PF16804.5 ETN99456.1 - 0.37 11.0 0.0 0.37 11.0 0.0 4.7 5 1 0 5 5 4 0 Domain of unknown function (DUF5071) OS-D PF03392.13 ETN99456.1 - 0.59 10.3 6.3 0.42 10.7 0.7 3.7 3 0 0 3 3 3 0 Insect pheromone-binding family, A10/OS-D EF-hand_7 PF13499.6 ETN99456.1 - 6.8 7.2 7.5 29 5.2 0.1 5.2 4 1 1 5 5 5 0 EF-hand domain pair Vac14_Fab1_bd PF12755.7 ETN99457.1 - 0.00029 21.4 0.2 0.1 13.2 0.0 1.9 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETN99457.1 - 0.00051 20.1 0.3 0.00055 20.0 0.3 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETN99457.1 - 0.00055 20.3 0.0 0.00075 19.8 0.0 1.2 1 0 0 1 1 1 1 HEAT repeats RTP1_C1 PF10363.9 ETN99457.1 - 0.00058 20.0 0.1 0.0048 17.1 0.0 1.9 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT PF02985.22 ETN99457.1 - 0.0034 17.5 0.0 1.4 9.3 0.0 2.4 2 0 0 2 2 2 2 HEAT repeat GhoS PF11080.8 ETN99457.1 - 0.022 14.7 0.0 0.051 13.5 0.0 1.6 1 1 1 2 2 2 0 Endoribonuclease GhoS TIP120 PF08623.10 ETN99457.1 - 0.1 12.3 0.1 0.14 12.0 0.1 1.3 1 1 0 1 1 1 0 TATA-binding protein interacting (TIP20) UCH PF00443.29 ETN99458.1 - 0.019 14.5 0.1 0.02 14.4 0.1 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DUF4519 PF15012.6 ETN99460.1 - 1.7 8.9 9.5 4.6 7.5 9.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) OST-HTH PF12872.7 ETN99461.1 - 0.15 11.9 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 OST-HTH/LOTUS domain WD40 PF00400.32 ETN99463.1 - 1.2e-44 149.3 15.3 3.4e-10 40.3 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99463.1 - 5.9e-12 45.7 0.3 0.0078 16.5 0.0 4.2 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99463.1 - 1.4e-07 31.2 0.0 0.16 11.3 0.0 3.2 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETN99463.1 - 5.1e-07 29.0 0.1 1.8 7.5 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Frtz PF11768.8 ETN99463.1 - 0.0018 16.7 0.0 3.6 5.8 0.0 3.3 1 1 3 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 ETN99463.1 - 0.0036 16.0 3.9 1.3 7.6 0.0 4.0 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETN99463.1 - 0.012 14.2 0.2 0.064 11.8 0.1 1.9 1 1 1 2 2 2 0 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETN99463.1 - 0.019 14.6 0.0 0.037 13.6 0.0 1.6 1 1 0 1 1 1 0 PQQ-like domain NYD-SP28_assoc PF14775.6 ETN99463.1 - 0.03 14.4 0.1 40 4.4 0.0 3.9 4 0 0 4 4 4 0 Sperm tail C-terminal domain PD40 PF07676.12 ETN99463.1 - 0.055 13.4 0.1 12 6.0 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETN99463.1 - 0.072 11.8 3.3 0.37 9.5 0.2 2.6 1 1 0 3 3 3 0 Nup133 N terminal like DUF1652 PF07865.11 ETN99463.1 - 0.13 12.1 0.0 28 4.6 0.0 3.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1652) DUF4420 PF14390.6 ETN99465.1 - 0.053 12.8 0.1 0.078 12.2 0.1 1.2 1 0 0 1 1 1 0 Putative PD-(D/E)XK family member, (DUF4420) Peroxin-22 PF12827.7 ETN99468.1 - 0.038 13.9 0.1 0.043 13.7 0.1 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family Ribonuc_L-PSP PF01042.21 ETN99468.1 - 0.11 12.5 0.0 0.12 12.3 0.0 1.1 1 0 0 1 1 1 0 Endoribonuclease L-PSP RsgA_GTPase PF03193.16 ETN99469.1 - 3.8e-06 26.9 0.1 6.2e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ETN99469.1 - 8.7e-05 23.1 1.7 0.00022 21.7 0.1 2.0 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETN99469.1 - 0.003 17.3 0.1 0.0054 16.4 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 ETN99469.1 - 0.007 15.5 0.0 0.0076 15.3 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_7 PF12775.7 ETN99469.1 - 0.021 14.4 0.0 0.031 13.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region MMR_HSR1 PF01926.23 ETN99469.1 - 0.026 14.6 1.6 0.029 14.5 0.1 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase DUF815 PF05673.13 ETN99469.1 - 0.032 13.4 0.2 0.065 12.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 ETN99469.1 - 0.043 14.1 0.0 0.14 12.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ETN99469.1 - 0.044 14.0 0.1 0.1 12.8 0.1 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase PduV-EutP PF10662.9 ETN99469.1 - 0.048 13.4 0.0 0.1 12.3 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_28 PF13521.6 ETN99469.1 - 0.17 12.1 0.8 0.44 10.8 0.1 1.9 2 1 0 2 2 2 0 AAA domain CN_hydrolase PF00795.22 ETN99471.1 - 3.5e-12 46.2 0.0 4.2e-12 46.0 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase NACHT PF05729.12 ETN99475.1 - 3.7e-08 33.5 0.0 5.8e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETN99475.1 - 7.3e-05 22.6 0.5 0.0073 16.2 0.0 2.9 2 1 0 2 2 2 1 STI1 domain EC042_2821 PF18740.1 ETN99476.1 - 0.057 13.3 1.9 0.07 13.0 1.9 1.1 1 0 0 1 1 1 0 EC042_2821-lke REase Ribosomal_S30AE PF02482.19 ETN99476.1 - 0.096 13.5 0.1 0.12 13.1 0.1 1.1 1 0 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein Peroxin-13_N PF04088.13 ETN99477.1 - 5.6 7.2 6.7 6.5 7.0 6.7 1.0 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Transferase PF02458.15 ETN99477.1 - 6.7 5.2 10.1 7.9 5.0 10.1 1.0 1 0 0 1 1 1 0 Transferase family PTR2 PF00854.21 ETN99477.1 - 9.9 4.9 5.9 10 4.8 5.9 1.0 1 0 0 1 1 1 0 POT family EF-hand_1 PF00036.32 ETN99478.1 - 1.2e-09 37.0 3.0 0.00055 19.3 0.3 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETN99478.1 - 3.7e-09 35.8 1.0 0.0015 18.3 0.3 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETN99478.1 - 4.9e-09 36.5 5.1 5.2e-07 30.0 0.3 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ETN99478.1 - 2.4e-06 26.8 1.9 0.0082 15.6 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETN99478.1 - 2.8e-06 27.0 1.2 1e-05 25.3 0.4 2.3 1 1 1 2 2 2 1 EF-hand domain pair FAM76 PF16046.5 ETN99478.1 - 0.0011 18.4 12.0 0.0011 18.4 12.0 2.8 3 0 0 3 3 3 2 FAM76 protein APG12 PF04110.13 ETN99478.1 - 0.0035 17.7 0.6 4.2 7.8 0.1 3.7 3 0 0 3 3 3 1 Ubiquitin-like autophagy protein Apg12 WD40_alt PF14077.6 ETN99478.1 - 1.2 9.1 11.9 0.24 11.3 0.5 4.2 4 0 0 4 4 4 0 Alternative WD40 repeat motif Atg14 PF10186.9 ETN99478.1 - 1.2 8.1 22.5 0.24 10.5 7.3 2.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 ETN99478.1 - 1.7 8.0 46.0 0.31 10.5 15.9 3.2 3 0 0 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF3037 PF11236.8 ETN99478.1 - 5.6 7.4 9.2 1 9.8 1.5 3.2 3 2 0 3 3 3 0 Protein of unknown function (DUF3037) Pox_A_type_inc PF04508.12 ETN99479.1 - 0.13 12.2 4.5 0.24 11.3 0.2 3.8 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Apolipoprotein PF01442.18 ETN99479.1 - 0.33 10.8 46.8 1.7 8.5 14.9 2.4 1 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF4407 PF14362.6 ETN99479.1 - 0.7 9.2 40.6 1.1 8.5 19.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) EF-hand_1 PF00036.32 ETN99480.1 - 0.089 12.4 0.0 0.21 11.2 0.0 1.6 1 0 0 1 1 1 0 EF hand HHH_7 PF14635.6 ETN99482.1 - 0.043 14.2 2.8 2.8 8.3 0.1 2.2 1 1 1 2 2 2 0 Helix-hairpin-helix motif 3-HAO PF06052.12 ETN99483.1 - 0.098 12.3 0.0 0.15 11.7 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase DUF3827 PF12877.7 ETN99484.1 - 0.0039 15.7 1.9 0.0046 15.4 1.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3827) Noggin PF05806.12 ETN99484.1 - 0.14 12.0 1.8 0.14 12.0 1.1 1.5 1 1 1 2 2 2 0 Noggin WD40 PF00400.32 ETN99485.1 - 4.4e-11 43.2 2.2 8.8e-06 26.4 0.5 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99485.1 - 0.0094 16.2 0.0 3.8 7.9 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99485.1 - 0.011 14.5 0.2 0.09 11.4 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 AAA_5 PF07728.14 ETN99489.1 - 0.0012 18.8 0.0 0.0063 16.5 0.0 2.3 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETN99489.1 - 0.0013 19.2 0.2 0.013 16.0 0.0 2.8 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) Thioredoxin_12 PF18400.1 ETN99489.1 - 0.031 14.1 0.2 0.14 12.0 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain AAA_22 PF13401.6 ETN99489.1 - 0.078 13.3 0.0 1.5 9.1 0.0 3.1 3 1 0 3 3 3 0 AAA domain CAP_GLY PF01302.25 ETN99490.1 - 2.6e-09 37.0 0.2 3.7e-09 36.5 0.1 1.4 1 1 0 1 1 1 1 CAP-Gly domain HEAT PF02985.22 ETN99491.1 - 0.00047 20.2 0.0 0.0013 18.8 0.0 1.8 1 0 0 1 1 1 1 HEAT repeat Activator-TraM PF11657.8 ETN99491.1 - 0.061 13.2 0.1 0.095 12.5 0.1 1.3 1 1 0 1 1 1 0 Transcriptional activator TraM HEAT_EZ PF13513.6 ETN99491.1 - 0.14 12.7 0.0 0.24 11.9 0.0 1.4 1 0 0 1 1 1 0 HEAT-like repeat DUF3349 PF11829.8 ETN99491.1 - 0.17 12.7 0.1 9.3 7.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3349) IGR PF09597.10 ETN99492.1 - 0.038 14.1 0.1 0.078 13.1 0.1 1.5 1 0 0 1 1 1 0 IGR protein motif Intein_splicing PF14890.6 ETN99493.1 - 3.6e-09 36.7 0.3 1.2e-08 34.9 0.3 1.8 1 1 0 1 1 1 1 Intein splicing domain Hint PF01079.20 ETN99493.1 - 7.4e-08 32.2 0.0 1.1e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 Hint module PT-HINT PF07591.11 ETN99493.1 - 2.1e-05 24.8 0.3 0.00029 21.1 0.6 2.5 2 1 0 2 2 2 1 Pretoxin HINT domain Asp_decarbox PF02261.16 ETN99493.1 - 0.0027 17.6 0.1 0.0042 17.0 0.1 1.3 1 0 0 1 1 1 1 Aspartate decarboxylase AXH PF08517.12 ETN99493.1 - 0.005 17.4 0.0 0.0093 16.5 0.0 1.5 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) Zn_Tnp_IS1595 PF12760.7 ETN99493.1 - 0.012 15.6 3.0 0.037 14.0 3.0 1.9 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Hom_end_hint PF05203.16 ETN99493.1 - 0.047 13.6 0.1 0.084 12.8 0.1 1.3 1 0 0 1 1 1 0 Hom_end-associated Hint Ribosomal_S17_N PF16205.5 ETN99496.1 - 7.8e-31 106.3 0.4 1.3e-30 105.6 0.4 1.4 1 0 0 1 1 1 1 Ribosomal_S17 N-terminal Ribosomal_S17 PF00366.20 ETN99496.1 - 1.1e-23 83.1 0.3 1.1e-23 83.1 0.3 1.7 2 0 0 2 2 2 1 Ribosomal protein S17 RRM_1 PF00076.22 ETN99497.1 - 3e-14 52.6 0.0 5.4e-14 51.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETN99497.1 - 0.0024 18.0 0.1 0.0079 16.3 0.0 2.0 1 1 0 1 1 1 1 RNA recognition motif NACHT PF05729.12 ETN99498.1 - 0.002 18.1 0.0 0.0032 17.4 0.0 1.2 1 1 0 1 1 1 1 NACHT domain DDE_3 PF13358.6 ETN99499.1 - 0.00027 20.7 0.3 0.00036 20.3 0.3 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease DUF2674 PF10879.8 ETN99499.1 - 0.068 12.7 1.1 0.14 11.7 1.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2674) VWA PF00092.28 ETN99501.1 - 0.022 15.0 0.0 0.031 14.5 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain TPR_12 PF13424.6 ETN99505.1 - 7.5e-33 112.7 7.0 1.2e-16 60.7 1.8 3.5 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99505.1 - 4.7e-20 70.1 4.6 3.7e-06 26.6 0.1 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99505.1 - 1.3e-19 69.4 0.6 6.1e-06 25.9 0.1 4.5 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99505.1 - 4.4e-19 67.0 14.3 2.1e-05 24.3 0.6 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99505.1 - 2.5e-18 65.0 20.2 1.6e-06 27.6 5.1 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99505.1 - 1e-17 62.8 21.6 1.9e-06 27.7 0.2 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99505.1 - 3.6e-08 33.9 0.0 0.034 14.8 0.0 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN99505.1 - 3.9e-08 33.4 3.9 0.099 13.3 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99505.1 - 1.9e-06 28.2 0.0 1.1 10.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99505.1 - 2.6e-06 27.0 22.4 0.00012 21.7 0.3 4.6 3 2 2 5 5 5 4 TPR repeat ANAPC3 PF12895.7 ETN99505.1 - 3e-06 27.4 6.7 0.00064 19.9 2.9 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETN99505.1 - 1e-05 25.1 0.0 0.074 12.4 0.0 2.0 1 1 1 2 2 2 2 MalT-like TPR region TPR_17 PF13431.6 ETN99505.1 - 0.00014 22.0 8.2 0.024 15.0 0.6 4.4 4 1 1 5 5 5 1 Tetratricopeptide repeat Phage_Treg PF04761.12 ETN99505.1 - 0.0015 18.6 8.1 0.026 14.6 0.2 3.5 3 1 1 4 4 4 1 Lactococcus bacteriophage putative transcription regulator RPN7 PF10602.9 ETN99505.1 - 0.018 14.7 8.9 0.48 10.1 0.6 3.2 1 1 2 3 3 3 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETN99505.1 - 0.018 15.5 1.7 5.4 7.6 0.1 3.1 3 1 1 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN99505.1 - 0.027 14.5 13.6 5.2 7.2 0.5 4.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 ETN99505.1 - 0.034 13.6 0.2 0.16 11.4 0.1 2.3 2 0 0 2 2 2 0 SHNi-TPR DUF5113 PF17140.4 ETN99505.1 - 0.049 13.4 9.6 0.56 10.0 1.8 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) Endonuclease_1 PF04231.13 ETN99505.1 - 0.072 12.8 2.6 0.069 12.8 1.4 1.5 1 1 0 1 1 1 0 Endonuclease I SPO22 PF08631.10 ETN99505.1 - 0.16 11.4 6.2 4.5 6.7 0.1 3.2 2 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like HTH_Bact PF18768.1 ETN99505.1 - 0.28 10.8 15.0 17 5.1 0.3 5.2 3 1 2 5 5 5 0 Helix-turn-helix bacterial domain DUF4058 PF13267.6 ETN99505.1 - 0.91 8.9 5.9 1.2 8.4 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4058) MIT PF04212.18 ETN99505.1 - 4.7 7.4 15.9 4.9 7.3 0.3 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Ank_2 PF12796.7 ETN99506.1 - 7.1e-11 42.5 0.0 0.00038 21.0 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETN99506.1 - 1.6e-05 25.1 0.1 0.11 12.8 0.0 3.4 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETN99506.1 - 3.5e-05 24.3 0.0 0.51 11.0 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETN99506.1 - 0.00067 19.9 0.0 4.7 8.1 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Fez1 PF06818.15 ETN99508.1 - 0.41 11.1 18.0 0.3 11.5 15.5 2.0 1 1 1 2 2 2 0 Fez1 ADIP PF11559.8 ETN99508.1 - 0.91 9.6 19.6 0.27 11.3 8.8 3.0 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding DUF2533 PF10752.9 ETN99508.1 - 1.5 9.3 5.7 2.1 8.9 2.1 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2533) Fib_alpha PF08702.10 ETN99508.1 - 1.9 8.7 16.7 0.16 12.1 2.5 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Dynamin_N PF00350.23 ETN99508.1 - 7.4 6.6 7.6 0.93 9.5 2.8 1.9 3 0 0 3 3 3 0 Dynamin family SNF2_N PF00176.23 ETN99509.1 - 2.6e-44 151.4 0.1 4.1e-21 75.1 0.1 2.5 2 0 0 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ETN99509.1 - 9.1e-10 38.9 0.0 2.7e-09 37.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 ETN99509.1 - 2.3e-08 33.9 5.9 6.7e-08 32.4 5.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETN99509.1 - 7.7e-08 32.1 4.4 2.2e-07 30.6 4.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETN99509.1 - 4.8e-07 29.5 6.3 4.8e-07 29.5 6.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETN99509.1 - 4.1e-06 26.5 3.0 1.1e-05 25.1 3.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETN99509.1 - 5.8e-06 26.4 5.4 1.5e-05 25.0 5.4 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING CDC27 PF09507.10 ETN99509.1 - 3.7e-05 23.3 34.0 3.7e-05 23.3 34.0 2.2 2 0 0 2 2 2 1 DNA polymerase subunit Cdc27 Prok-RING_4 PF14447.6 ETN99509.1 - 0.00015 21.6 4.0 0.00074 19.3 4.2 2.1 1 1 1 2 2 2 2 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETN99509.1 - 0.00016 21.9 5.6 0.00016 21.9 5.6 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETN99509.1 - 0.0002 21.3 4.7 0.00064 19.6 4.7 1.9 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETN99509.1 - 0.063 13.0 7.8 0.16 11.8 7.8 1.8 1 0 0 1 1 1 0 RING-like zinc finger LAP1C PF05609.12 ETN99509.1 - 0.083 12.0 24.2 0.16 11.0 24.2 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) zf-rbx1 PF12678.7 ETN99509.1 - 0.093 13.0 2.6 0.38 11.1 2.6 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain Menin PF05053.13 ETN99510.1 - 6.2 5.0 16.8 6 5.1 16.8 1.2 1 0 0 1 1 1 0 Menin Sec8_exocyst PF04048.14 ETN99511.1 - 0.00012 22.0 1.0 0.00012 22.0 1.0 2.1 1 1 1 2 2 2 1 Sec8 exocyst complex component specific domain AAA_13 PF13166.6 ETN99511.1 - 0.00051 18.8 9.6 0.00057 18.7 9.6 1.0 1 0 0 1 1 1 1 AAA domain Fib_alpha PF08702.10 ETN99511.1 - 0.00082 19.6 11.8 0.064 13.4 7.5 2.1 1 1 1 2 2 2 2 Fibrinogen alpha/beta chain family DUF3584 PF12128.8 ETN99511.1 - 0.0014 16.3 8.9 0.0018 15.9 8.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Spc7 PF08317.11 ETN99511.1 - 0.0018 17.2 15.1 0.0023 16.9 15.1 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein RPW8 PF05659.11 ETN99511.1 - 0.0019 17.9 6.6 0.0028 17.3 6.6 1.4 1 1 0 1 1 1 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF4200 PF13863.6 ETN99511.1 - 0.0038 17.6 19.4 0.067 13.6 17.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) She9_MDM33 PF05546.11 ETN99511.1 - 0.0052 16.6 5.5 0.0098 15.7 5.4 1.6 1 1 0 1 1 1 1 She9 / Mdm33 family TPR_MLP1_2 PF07926.12 ETN99511.1 - 0.024 14.7 21.3 0.19 11.8 21.3 1.9 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein HMMR_N PF15905.5 ETN99511.1 - 0.024 14.1 15.9 0.032 13.7 15.9 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Vps5 PF09325.10 ETN99511.1 - 0.025 14.1 0.3 0.025 14.1 0.3 2.1 1 1 1 2 2 2 0 Vps5 C terminal like Exonuc_VII_L PF02601.15 ETN99511.1 - 0.031 13.8 4.7 0.04 13.5 4.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 ETN99511.1 - 0.063 13.8 16.4 0.089 13.3 16.4 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region Spectrin PF00435.21 ETN99511.1 - 0.067 13.7 13.1 1.3 9.5 9.5 2.1 2 0 0 2 2 2 0 Spectrin repeat T3SS_needle_E PF08988.10 ETN99511.1 - 0.067 13.3 4.3 3.2 8.0 0.7 3.0 1 1 2 3 3 3 0 Type III secretion system, cytoplasmic E component of needle MreB_Mbl PF06723.13 ETN99511.1 - 0.075 11.8 1.2 0.084 11.7 1.2 1.1 1 0 0 1 1 1 0 MreB/Mbl protein Jnk-SapK_ap_N PF09744.9 ETN99511.1 - 0.076 13.2 20.1 2.1 8.6 16.1 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3416 PF11896.8 ETN99511.1 - 0.099 12.9 4.0 0.14 12.5 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3416) DUF1664 PF07889.12 ETN99511.1 - 0.1 12.6 11.3 2.7 8.0 6.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Borrelia_P83 PF05262.11 ETN99511.1 - 0.13 10.7 13.4 0.16 10.5 13.4 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Laminin_II PF06009.12 ETN99511.1 - 0.13 12.2 12.7 0.13 12.3 2.8 2.1 1 1 1 2 2 2 0 Laminin Domain II Fzo_mitofusin PF04799.13 ETN99511.1 - 0.14 11.7 10.1 0.083 12.4 1.0 2.2 1 1 1 2 2 2 0 fzo-like conserved region MerR-DNA-bind PF09278.11 ETN99511.1 - 0.14 12.7 8.9 3.1 8.4 4.4 2.3 2 1 0 2 2 2 0 MerR, DNA binding Helo_like_N PF17111.5 ETN99511.1 - 0.14 11.5 8.9 0.014 14.7 1.7 1.9 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins DUF745 PF05335.13 ETN99511.1 - 0.15 11.8 10.4 0.3 10.8 10.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) WXG100 PF06013.12 ETN99511.1 - 0.15 12.3 4.9 12 6.2 0.1 2.9 2 1 1 3 3 3 0 Proteins of 100 residues with WXG Baculo_PEP_C PF04513.12 ETN99511.1 - 0.15 12.1 2.4 5.1 7.1 0.1 2.2 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DLP_helical PF18709.1 ETN99511.1 - 0.18 11.0 10.1 0.47 9.6 10.1 1.6 1 1 1 2 2 2 0 Dynamin-like helical domain DUF4407 PF14362.6 ETN99511.1 - 0.19 11.0 7.6 0.27 10.5 7.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 ETN99511.1 - 0.21 10.8 12.6 0.014 14.6 2.3 2.0 1 1 1 2 2 2 0 TMPIT-like protein FapA PF03961.13 ETN99511.1 - 0.22 10.1 11.5 0.29 9.7 11.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A FUSC PF04632.12 ETN99511.1 - 0.26 9.8 0.5 0.3 9.6 0.5 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF3552 PF12072.8 ETN99511.1 - 0.28 10.6 23.5 0.41 10.0 18.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DASH_Dam1 PF08653.10 ETN99511.1 - 0.31 10.9 1.3 2.2 8.2 0.1 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 Seryl_tRNA_N PF02403.22 ETN99511.1 - 0.32 11.3 20.1 4.8 7.5 20.1 2.1 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Sec34 PF04136.15 ETN99511.1 - 0.34 10.8 9.5 5.2 6.9 5.2 2.1 2 0 0 2 2 2 0 Sec34-like family Fmp27_WPPW PF10359.9 ETN99511.1 - 0.38 9.6 13.4 0.94 8.3 13.4 1.5 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Syntaxin-6_N PF09177.11 ETN99511.1 - 0.4 11.3 10.8 1.8 9.2 1.3 2.1 1 1 1 2 2 2 0 Syntaxin 6, N-terminal OmpH PF03938.14 ETN99511.1 - 0.49 10.7 20.9 30 5.0 20.9 2.1 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) V_ATPase_I PF01496.19 ETN99511.1 - 0.57 8.0 6.8 0.72 7.7 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ING PF12998.7 ETN99511.1 - 0.89 10.2 11.7 0.55 10.8 6.8 2.1 1 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding CLZ PF16526.5 ETN99511.1 - 0.92 9.9 15.7 1.5 9.3 0.3 2.7 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels PhoU PF01895.19 ETN99511.1 - 0.98 9.9 12.7 84 3.7 9.3 3.0 1 1 1 2 2 2 0 PhoU domain DUF4618 PF15397.6 ETN99511.1 - 1 8.8 15.7 6.8 6.0 0.2 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) Prefoldin PF02996.17 ETN99511.1 - 1.1 9.2 18.7 1.3 8.9 0.2 2.8 1 1 1 2 2 2 0 Prefoldin subunit MIP-T3_C PF17749.1 ETN99511.1 - 1.1 9.2 16.4 1.8 8.5 14.1 1.8 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region CorA PF01544.18 ETN99511.1 - 1.1 8.5 8.9 1.4 8.2 0.2 2.1 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Prominin PF05478.11 ETN99511.1 - 1.3 6.9 8.1 2.7 5.8 8.2 1.4 1 1 0 1 1 1 0 Prominin CREPT PF16566.5 ETN99511.1 - 1.3 9.1 13.7 14 5.8 10.7 2.1 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Med9 PF07544.13 ETN99511.1 - 1.4 9.0 15.8 0.21 11.7 4.0 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Nup54 PF13874.6 ETN99511.1 - 1.5 8.9 9.9 8.3 6.5 9.9 1.9 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 TMF_DNA_bd PF12329.8 ETN99511.1 - 1.6 8.7 24.0 11 6.1 6.1 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.11 ETN99511.1 - 1.7 9.0 6.2 16 5.8 0.1 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) YabA PF06156.13 ETN99511.1 - 1.7 9.3 10.1 7.8 7.2 10.1 1.9 1 1 0 1 1 1 0 Initiation control protein YabA DUF4549 PF15082.6 ETN99511.1 - 1.8 8.4 11.9 0.075 12.8 0.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4549) UPF0449 PF15136.6 ETN99511.1 - 1.8 9.1 13.4 31 5.1 9.8 2.5 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 FAM76 PF16046.5 ETN99511.1 - 1.9 7.8 17.3 1.6 8.0 13.0 1.8 1 1 1 2 2 2 0 FAM76 protein CCDC-167 PF15188.6 ETN99511.1 - 1.9 8.9 16.1 0.042 14.2 3.6 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Holin_BhlA PF10960.8 ETN99511.1 - 2.6 8.1 12.1 2.1 8.4 0.3 2.5 1 1 2 3 3 2 0 BhlA holin family HAUS6_N PF14661.6 ETN99511.1 - 3.3 7.2 11.6 11 5.5 11.6 1.8 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus THOC7 PF05615.13 ETN99511.1 - 4.3 7.6 16.7 19 5.6 16.1 2.1 1 1 0 1 1 1 0 Tho complex subunit 7 MCU PF04678.13 ETN99511.1 - 4.6 7.3 10.3 20 5.2 10.3 1.8 1 1 0 1 1 1 0 Mitochondrial calcium uniporter Sec2p PF06428.11 ETN99511.1 - 4.7 7.3 20.8 4.4 7.4 6.4 3.0 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p DUF4375 PF14300.6 ETN99511.1 - 6.1 7.1 9.7 7.8 6.8 8.9 1.5 1 1 1 2 2 1 0 Domain of unknown function (DUF4375) Atg14 PF10186.9 ETN99511.1 - 7.5 5.5 15.4 17 4.4 15.4 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2203 PF09969.9 ETN99511.1 - 8.2 7.2 11.0 19 6.0 7.8 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Glyco_hydro_79n PF03662.14 ETN99512.1 - 0.03 13.2 0.0 0.039 12.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain zf-UBR PF02207.20 ETN99512.1 - 0.034 14.3 0.6 0.083 13.1 0.6 1.6 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF4798 PF16055.5 ETN99513.1 - 0.27 11.5 3.8 0.4 10.9 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) Trimer_CC PF08954.11 ETN99514.1 - 0.11 12.1 0.3 1 9.0 0.2 2.3 1 1 1 2 2 2 0 Trimerisation motif Jnk-SapK_ap_N PF09744.9 ETN99516.1 - 0.0018 18.6 18.1 0.29 11.4 11.7 2.0 1 1 1 2 2 2 2 JNK_SAPK-associated protein-1 Mod_r PF07200.13 ETN99516.1 - 0.019 15.0 16.7 0.033 14.3 10.5 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein TACC_C PF05010.14 ETN99516.1 - 0.029 14.2 13.1 0.034 13.9 13.1 1.1 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Laminin_II PF06009.12 ETN99516.1 - 0.037 14.0 6.2 0.045 13.8 0.2 2.2 1 1 1 2 2 2 0 Laminin Domain II SlyX PF04102.12 ETN99516.1 - 0.037 14.6 3.7 0.94 10.1 0.1 2.9 1 1 2 3 3 3 0 SlyX TPR_MLP1_2 PF07926.12 ETN99516.1 - 0.058 13.4 17.7 0.16 12.0 11.8 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein GDNF PF02351.16 ETN99516.1 - 0.063 14.3 8.9 0.055 14.4 3.5 2.1 1 1 1 2 2 2 0 GDNF/GAS1 domain Tup_N PF08581.10 ETN99516.1 - 0.11 12.8 11.4 1.4 9.3 0.1 3.5 2 1 1 3 3 3 0 Tup N-terminal EzrA PF06160.12 ETN99516.1 - 0.13 10.5 15.9 0.14 10.3 15.9 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA bZIP_1 PF00170.21 ETN99516.1 - 0.13 12.4 0.3 0.13 12.4 0.3 3.5 1 1 3 4 4 4 0 bZIP transcription factor Synaptobrevin PF00957.21 ETN99516.1 - 0.14 11.9 2.7 3.9 7.3 0.1 2.3 2 0 0 2 2 2 0 Synaptobrevin IFT57 PF10498.9 ETN99516.1 - 0.16 10.9 16.1 0.24 10.4 15.4 1.5 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Snapin_Pallidin PF14712.6 ETN99516.1 - 0.16 12.4 9.7 0.38 11.2 1.1 2.6 1 1 0 2 2 2 0 Snapin/Pallidin Rootletin PF15035.6 ETN99516.1 - 0.19 11.8 16.5 0.51 10.3 3.8 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Filament PF00038.21 ETN99516.1 - 0.28 10.7 13.8 0.16 11.5 3.9 2.2 1 1 1 2 2 2 0 Intermediate filament protein DegS PF05384.11 ETN99516.1 - 0.29 10.6 13.6 0.2 11.2 2.5 2.1 1 1 1 2 2 2 0 Sensor protein DegS YabA PF06156.13 ETN99516.1 - 0.36 11.5 13.1 2.4 8.9 0.9 2.1 1 1 1 2 2 2 0 Initiation control protein YabA DUF4200 PF13863.6 ETN99516.1 - 0.46 10.9 14.0 0.56 10.6 8.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) YkyA PF10368.9 ETN99516.1 - 0.58 9.8 15.5 0.72 9.5 15.5 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein Exonuc_VII_L PF02601.15 ETN99516.1 - 0.76 9.3 8.4 0.91 9.0 8.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.9 ETN99516.1 - 0.84 9.7 17.1 0.99 9.4 2.6 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TolA_bind_tri PF16331.5 ETN99516.1 - 0.86 9.7 5.1 13 5.9 2.4 2.8 1 1 2 3 3 3 0 TolA binding protein trimerisation APG6_N PF17675.1 ETN99516.1 - 0.88 10.1 18.1 0.2 12.2 4.7 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region HR1 PF02185.16 ETN99516.1 - 0.93 9.7 6.5 0.85 9.8 1.7 3.0 1 1 1 2 2 2 0 Hr1 repeat MscS_porin PF12795.7 ETN99516.1 - 0.95 9.0 6.8 1.3 8.5 0.6 1.9 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain DUF1664 PF07889.12 ETN99516.1 - 1.4 8.9 8.5 11 6.0 4.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ZapB PF06005.12 ETN99516.1 - 1.6 9.2 13.0 0.48 10.9 0.7 2.9 1 1 1 2 2 2 0 Cell division protein ZapB CheZ PF04344.13 ETN99516.1 - 1.8 8.4 6.3 3.4 7.5 6.2 1.6 1 1 0 1 1 1 0 Chemotaxis phosphatase, CheZ KELK PF15796.5 ETN99516.1 - 4.4 7.8 12.6 2.1 8.8 1.4 2.7 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase TMPIT PF07851.13 ETN99516.1 - 5.1 6.2 16.5 0.23 10.7 7.8 1.9 1 1 1 2 2 2 0 TMPIT-like protein UPF0242 PF06785.11 ETN99516.1 - 5.9 6.9 17.8 0.86 9.7 7.7 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus JIP_LZII PF16471.5 ETN99516.1 - 9 6.6 10.8 5.9 7.1 0.5 2.8 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II DUF3130 PF11328.8 ETN99521.1 - 0.0077 16.5 0.1 0.033 14.4 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF3130 DUF272 PF03312.15 ETN99521.1 - 0.023 15.0 1.0 0.03 14.6 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF272) WD40 PF00400.32 ETN99522.1 - 2.5e-41 138.9 12.7 3.5e-11 43.5 0.3 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99522.1 - 1.2e-17 64.0 0.4 0.0048 17.2 0.0 4.9 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99522.1 - 3e-13 49.3 1.2 0.00062 18.5 0.0 4.9 2 1 3 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETN99522.1 - 4.1e-09 36.6 0.1 0.0037 17.2 0.0 2.7 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETN99522.1 - 5.3e-06 25.6 0.2 0.99 8.3 0.0 3.7 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETN99522.1 - 2.1e-05 24.0 1.0 0.011 15.1 0.2 2.8 1 1 1 3 3 3 2 WD40-like domain PALB2_WD40 PF16756.5 ETN99522.1 - 3.2e-05 23.0 1.3 0.21 10.5 0.1 3.6 1 1 3 4 4 4 2 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETN99522.1 - 0.0016 18.3 3.7 0.58 10.2 1.5 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETN99522.1 - 0.0089 16.1 0.6 5.7 7.0 0.0 3.3 1 1 2 4 4 4 1 Family of unknown function (DUF5570) RicinB_lectin_2 PF14200.6 ETN99522.1 - 0.019 15.7 0.1 0.062 14.0 0.1 1.9 2 1 0 2 2 1 0 Ricin-type beta-trefoil lectin domain-like PQQ PF01011.21 ETN99522.1 - 0.041 13.8 0.0 44 4.2 0.0 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETN99522.1 - 0.047 13.4 0.1 13 5.6 0.0 2.8 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature DUF5474 PF17568.2 ETN99522.1 - 0.062 13.4 0.5 4.5 7.4 0.1 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5474) DUF1513 PF07433.11 ETN99522.1 - 0.15 11.1 0.0 2.8 7.0 0.0 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF1513) TPR_2 PF07719.17 ETN99523.1 - 1.8e-06 27.6 7.5 0.0037 17.2 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99523.1 - 0.0001 22.0 8.8 0.0063 16.3 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99523.1 - 0.00011 21.9 1.5 0.43 10.3 0.1 3.6 3 1 0 3 3 3 2 TPR repeat TPR_19 PF14559.6 ETN99523.1 - 0.00016 22.1 1.8 0.029 14.9 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETN99523.1 - 0.0004 19.8 0.3 1.1 8.7 0.1 2.5 2 0 0 2 2 2 2 SHNi-TPR TPR_8 PF13181.6 ETN99523.1 - 0.0018 18.4 2.4 0.64 10.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99523.1 - 0.0018 18.1 1.2 1.9 8.5 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETN99523.1 - 0.0081 16.4 4.9 0.74 10.1 0.9 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETN99523.1 - 0.0082 16.7 2.3 0.44 11.3 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TMEM108 PF15759.5 ETN99523.1 - 0.014 14.4 3.4 0.021 13.9 3.4 1.2 1 0 0 1 1 1 0 TMEM108 family Med3 PF11593.8 ETN99523.1 - 0.077 12.2 4.5 0.1 11.8 4.5 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF3439 PF11921.8 ETN99523.1 - 0.14 12.1 4.9 0.22 11.5 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TPR_7 PF13176.6 ETN99523.1 - 0.38 10.9 3.8 4.1 7.7 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat PUB PF09409.10 ETN99524.1 - 0.00037 20.4 3.6 0.0011 18.9 2.0 2.5 1 1 1 2 2 2 1 PUB domain HCR PF07111.12 ETN99524.1 - 0.035 12.2 0.3 0.04 12.0 0.3 1.0 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) Sulfolobus_pRN PF05584.11 ETN99524.1 - 0.064 13.3 1.4 0.39 10.8 0.0 2.6 1 1 2 3 3 3 0 Sulfolobus plasmid regulatory protein DUF4472 PF14739.6 ETN99526.1 - 0.0055 17.4 13.4 0.0055 17.4 13.4 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4472) TPR_MLP1_2 PF07926.12 ETN99526.1 - 0.0067 16.5 21.6 0.0067 16.5 21.6 2.0 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein ZapB PF06005.12 ETN99526.1 - 0.015 15.7 32.9 0.46 11.0 15.0 2.1 1 1 1 2 2 2 0 Cell division protein ZapB CALCOCO1 PF07888.11 ETN99526.1 - 0.029 13.2 23.8 0.032 13.1 23.8 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc7 PF08317.11 ETN99526.1 - 0.042 12.7 27.4 0.046 12.6 27.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein APG6_N PF17675.1 ETN99526.1 - 0.047 14.2 28.2 0.022 15.3 25.7 1.6 1 1 1 2 2 2 0 Apg6 coiled-coil region KASH_CCD PF14662.6 ETN99526.1 - 0.052 13.4 29.1 0.28 11.0 13.7 2.0 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH ING PF12998.7 ETN99526.1 - 0.054 14.1 17.5 0.07 13.7 17.5 1.2 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding ATG16 PF08614.11 ETN99526.1 - 0.058 13.6 24.5 0.087 13.0 24.5 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 ETN99526.1 - 0.063 13.0 28.9 0.072 12.8 28.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) Cep57_CLD_2 PF14197.6 ETN99526.1 - 0.068 13.3 25.0 1.8 8.7 1.0 3.4 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 OmpH PF03938.14 ETN99526.1 - 0.079 13.3 28.1 0.096 13.0 28.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Shugoshin_N PF07558.11 ETN99526.1 - 0.091 12.6 0.7 0.091 12.6 0.7 4.2 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region Laminin_II PF06009.12 ETN99526.1 - 0.11 12.5 17.2 0.15 12.1 16.9 1.4 1 1 0 1 1 1 0 Laminin Domain II DUF4200 PF13863.6 ETN99526.1 - 0.13 12.7 32.1 0.16 12.4 32.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF2730 PF10805.8 ETN99526.1 - 0.15 12.1 11.9 0.22 11.6 11.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) Mto2_bdg PF12808.7 ETN99526.1 - 0.17 12.2 13.4 0.2 12.0 1.4 2.9 2 1 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF3584 PF12128.8 ETN99526.1 - 0.18 9.3 25.0 0.19 9.2 25.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) UPF0242 PF06785.11 ETN99526.1 - 0.18 11.9 31.0 0.054 13.6 17.3 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus COG5 PF10392.9 ETN99526.1 - 0.23 11.6 13.3 1.2 9.3 0.6 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 HMMR_N PF15905.5 ETN99526.1 - 0.27 10.7 29.7 0.29 10.5 29.7 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal HIP1_clath_bdg PF16515.5 ETN99526.1 - 0.55 10.9 27.7 0.15 12.6 20.7 2.1 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2968 PF11180.8 ETN99526.1 - 0.77 9.4 16.8 1 9.0 16.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) CtIP_N PF10482.9 ETN99526.1 - 0.82 9.7 25.7 0.25 11.4 10.7 3.0 1 1 2 3 3 3 0 Tumour-suppressor protein CtIP N-terminal domain Atg14 PF10186.9 ETN99526.1 - 0.87 8.6 22.5 1 8.4 22.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1515 PF07439.11 ETN99526.1 - 0.94 9.5 9.1 0.23 11.5 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) TSC22 PF01166.18 ETN99526.1 - 0.95 9.8 20.4 0.11 12.8 6.9 3.2 1 1 2 3 3 3 0 TSC-22/dip/bun family CC2-LZ PF16516.5 ETN99526.1 - 1.1 9.6 25.1 0.83 10.1 9.2 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ADIP PF11559.8 ETN99526.1 - 1.3 9.1 28.9 0.8 9.8 16.5 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3450 PF11932.8 ETN99526.1 - 1.3 8.3 23.9 1.4 8.2 23.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 ETN99526.1 - 1.5 9.0 28.0 8.9 6.5 17.2 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Tropomyosin_1 PF12718.7 ETN99526.1 - 1.6 8.8 31.9 0.22 11.7 13.9 2.0 1 1 1 2 2 2 0 Tropomyosin like DUF724 PF05266.14 ETN99526.1 - 1.7 8.4 26.6 1.4 8.7 21.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Spectrin PF00435.21 ETN99526.1 - 1.7 9.1 22.1 3.1 8.3 13.3 2.5 1 1 0 2 2 2 0 Spectrin repeat AAA_13 PF13166.6 ETN99526.1 - 1.7 7.2 21.9 2 7.0 21.9 1.1 1 0 0 1 1 1 0 AAA domain Golgin_A5 PF09787.9 ETN99526.1 - 1.8 7.9 29.4 2 7.8 29.4 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 BRE1 PF08647.11 ETN99526.1 - 2.2 8.4 31.2 40 4.4 31.2 2.2 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase YabA PF06156.13 ETN99526.1 - 2.7 8.7 24.5 4 8.1 9.3 2.3 1 1 1 2 2 2 0 Initiation control protein YabA CRR7 PF12095.8 ETN99526.1 - 2.8 8.5 12.7 2.2 8.8 10.8 1.8 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Fib_alpha PF08702.10 ETN99526.1 - 3.3 7.9 23.5 0.76 10.0 14.5 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Seryl_tRNA_N PF02403.22 ETN99526.1 - 3.6 7.9 27.9 0.54 10.5 14.2 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3087 PF11286.8 ETN99526.1 - 4.4 6.8 10.4 5.6 6.4 10.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) APC_N_CC PF16689.5 ETN99526.1 - 4.4 7.4 19.4 0.38 10.8 9.2 2.9 1 1 2 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain DUF4407 PF14362.6 ETN99526.1 - 5.5 6.2 18.8 6.1 6.1 18.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FixO PF02433.15 ETN99526.1 - 5.8 6.3 8.6 6.9 6.1 8.6 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO Spc24 PF08286.11 ETN99526.1 - 6.2 7.1 26.7 6.3 7.1 11.8 2.2 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Exonuc_VII_L PF02601.15 ETN99526.1 - 7.2 6.1 18.2 7.3 6.1 18.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF641 PF04859.12 ETN99526.1 - 7.4 6.9 18.3 0.72 10.2 12.3 1.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Z1 PF10593.9 ETN99526.1 - 8.8 5.8 13.8 11 5.4 13.8 1.1 1 0 0 1 1 1 0 Z1 domain MipZ PF09140.11 ETN99527.1 - 0.062 12.6 0.3 0.11 11.7 0.1 1.4 2 0 0 2 2 2 0 ATPase MipZ Peptidase_C14 PF00656.22 ETN99528.1 - 0.00053 20.0 0.6 0.00071 19.6 0.6 1.3 1 1 0 1 1 1 1 Caspase domain DDE_3 PF13358.6 ETN99528.1 - 0.0058 16.4 0.1 0.0062 16.3 0.1 1.2 1 0 0 1 1 1 1 DDE superfamily endonuclease TLD PF07534.16 ETN99529.1 - 6.1e-17 62.1 1.6 6.1e-17 62.1 1.6 1.6 2 0 0 2 2 2 1 TLD Ras PF00071.22 ETN99530.1 - 2e-21 76.3 0.5 2.2e-21 76.1 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETN99530.1 - 0.0026 18.0 0.1 0.0066 16.7 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Galactosyl_T PF01762.21 ETN99530.1 - 0.012 15.4 0.0 0.013 15.3 0.0 1.0 1 0 0 1 1 1 0 Galactosyltransferase SNF2_N PF00176.23 ETN99530.1 - 0.03 13.1 0.0 0.03 13.1 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain TipAS PF07739.13 ETN99530.1 - 0.079 13.5 0.2 0.084 13.4 0.2 1.2 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain GEN1_C PF18380.1 ETN99531.1 - 0.079 13.9 7.6 0.18 12.7 0.7 2.7 2 1 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain BRCT_2 PF16589.5 ETN99531.1 - 0.087 13.2 0.0 0.087 13.2 0.0 2.2 3 1 0 3 3 3 0 BRCT domain, a BRCA1 C-terminus domain FAM176 PF14851.6 ETN99531.1 - 1.7 8.3 6.7 8.4 6.0 0.2 2.2 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 ETN99531.1 - 5.2 7.1 11.4 14 5.7 5.3 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal TPR_12 PF13424.6 ETN99533.1 - 2.4e-42 143.1 20.2 1.6e-18 66.8 3.8 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99533.1 - 1.2e-25 88.3 21.5 1.9e-09 37.0 3.6 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99533.1 - 2.7e-23 80.2 14.9 1.8e-07 30.8 1.4 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99533.1 - 1.1e-22 79.2 2.6 7.7e-09 35.2 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99533.1 - 1.5e-16 59.1 4.4 1.5e-05 24.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99533.1 - 6.6e-15 54.0 18.6 4.9e-05 23.2 0.6 4.0 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99533.1 - 2.6e-12 46.2 20.1 0.00016 21.3 0.9 4.5 4 1 1 5 5 4 4 TPR repeat TPR_6 PF13174.6 ETN99533.1 - 1e-09 38.4 1.3 0.15 12.7 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99533.1 - 1.1e-09 38.0 11.4 0.0023 18.2 0.6 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99533.1 - 1.5e-09 38.3 0.0 0.0004 21.0 0.1 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99533.1 - 3.3e-08 33.7 0.0 0.015 16.1 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETN99533.1 - 1.9e-05 25.1 0.8 0.005 17.3 0.3 2.5 1 1 1 2 2 2 2 Tetratricopeptide repeat SNAP PF14938.6 ETN99533.1 - 5e-05 22.9 6.9 0.0034 16.9 2.8 2.4 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 ETN99533.1 - 0.00048 20.3 15.0 0.0078 16.4 5.4 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETN99533.1 - 0.0012 18.2 0.6 1.9 8.0 0.0 3.3 3 0 0 3 3 3 1 SHNi-TPR TPR_MalT PF17874.1 ETN99533.1 - 0.0051 16.2 0.0 0.0085 15.5 0.0 1.3 1 0 0 1 1 1 1 MalT-like TPR region HTH_Bact PF18768.1 ETN99533.1 - 0.0077 15.8 4.6 2.7 7.7 0.0 3.9 3 1 0 3 3 3 1 Helix-turn-helix bacterial domain PPR PF01535.20 ETN99533.1 - 0.023 14.9 1.6 13 6.3 0.1 3.6 3 0 0 3 3 3 0 PPR repeat MIT PF04212.18 ETN99533.1 - 0.033 14.2 13.3 0.042 13.9 0.6 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF3899 PF13038.6 ETN99533.1 - 0.085 13.4 0.1 0.085 13.4 0.1 2.1 3 1 0 3 3 2 0 Domain of unknown function (DUF3899) SPO22 PF08631.10 ETN99533.1 - 0.15 11.6 9.3 0.26 10.7 1.1 2.9 1 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like DUF5113 PF17140.4 ETN99533.1 - 0.18 11.6 22.6 0.13 12.0 0.7 4.0 2 1 2 4 4 4 0 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETN99533.1 - 0.27 12.0 11.6 4 8.2 0.3 4.8 5 1 0 5 5 3 0 Sel1 repeat DUF627 PF04781.12 ETN99533.1 - 0.37 10.8 5.5 2.5 8.2 0.3 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF627) Rapsyn_N PF10579.9 ETN99533.1 - 0.47 10.6 5.7 13 6.0 0.0 4.0 3 2 0 4 4 4 0 Rapsyn N-terminal myristoylation and linker region NYD-SP28_assoc PF14775.6 ETN99533.1 - 0.74 10.0 6.4 3.2 7.9 0.8 3.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain TPR_3 PF07720.12 ETN99533.1 - 0.79 9.8 21.3 0.067 13.2 3.7 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Lipoprotein_15 PF03640.15 ETN99536.1 - 0.11 12.0 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 Secreted repeat of unknown function FERM_N PF09379.10 ETN99536.1 - 0.19 11.7 1.7 0.47 10.4 1.0 2.2 2 1 0 2 2 2 0 FERM N-terminal domain MS_channel PF00924.18 ETN99538.1 - 6.4e-17 61.8 1.9 6.4e-17 61.8 1.9 2.0 2 0 0 2 2 2 1 Mechanosensitive ion channel RhoGAP-FF1 PF16512.5 ETN99543.1 - 0.0063 17.2 2.3 0.033 14.9 0.5 2.5 2 0 0 2 2 2 1 p190-A and -B Rho GAPs FF domain Peptidase_C14 PF00656.22 ETN99545.1 - 3.9e-12 46.7 0.8 5.1e-12 46.3 0.8 1.1 1 0 0 1 1 1 1 Caspase domain NblA PF04485.12 ETN99545.1 - 0.16 12.4 0.0 0.34 11.3 0.0 1.5 1 0 0 1 1 1 0 Phycobilisome degradation protein nblA Ldl_recept_a PF00057.18 ETN99546.1 - 0.021 15.1 2.8 0.042 14.1 2.8 1.5 1 0 0 1 1 1 0 Low-density lipoprotein receptor domain class A VASP_tetra PF08776.11 ETN99546.1 - 0.088 12.4 0.9 2.5 7.7 0.1 2.8 2 0 0 2 2 2 0 VASP tetramerisation domain NIF PF03031.18 ETN99547.1 - 5.4e-32 110.7 0.0 9.4e-32 109.9 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase WD40 PF00400.32 ETN99550.1 - 2e-19 69.5 6.2 1.7e-05 25.5 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETN99550.1 - 0.0023 16.9 0.2 0.073 12.0 0.2 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETN99550.1 - 0.003 17.8 0.1 7.7 6.9 0.0 3.6 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_38N PF01074.22 ETN99551.1 - 0.042 13.2 0.0 0.087 12.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 N-terminal domain DRY_EERY PF09750.9 ETN99551.1 - 0.092 13.0 0.3 0.17 12.1 0.3 1.5 1 0 0 1 1 1 0 Alternative splicing regulator Syntaxin_2 PF14523.6 ETN99552.1 - 0.079 13.3 2.0 0.11 12.9 0.4 1.9 1 1 1 2 2 2 0 Syntaxin-like protein baeRF_family12 PF18856.1 ETN99555.1 - 0.075 13.6 5.1 0.093 13.3 4.2 1.5 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 KfrA_N PF11740.8 ETN99555.1 - 0.31 11.7 4.7 0.41 11.3 1.0 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term CDC45 PF02724.14 ETN99555.1 - 0.41 8.9 10.9 0.5 8.6 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETN99555.1 - 2.4 8.4 12.1 3.8 7.8 12.1 1.3 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 WD40 PF00400.32 ETN99556.1 - 1.6e-20 73.0 3.4 1.1e-06 29.2 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99556.1 - 1.6e-06 28.3 0.4 0.4 11.0 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99556.1 - 3e-06 26.2 0.1 0.11 11.1 0.0 2.9 1 1 1 3 3 3 3 Nucleoporin Nup120/160 Read-through PF16814.5 ETN99556.1 - 0.011 15.5 0.3 0.16 11.8 0.1 2.3 1 1 1 2 2 2 0 Read-through domain CENP-B_dimeris PF09026.10 ETN99558.1 - 0.063 13.7 5.5 5.7 7.4 3.8 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain SARAF PF06682.12 ETN99558.1 - 1.6 8.3 3.9 28 4.2 0.0 3.1 3 1 2 5 5 5 0 SOCE-associated regulatory factor of calcium homoeostasis MAP17 PF15807.5 ETN99559.1 - 1.7 8.9 12.1 0.37 11.0 7.0 2.1 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4551 PF15087.6 ETN99559.1 - 4.6 6.0 10.3 5.4 5.7 10.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Peptidase_S49_N PF08496.10 ETN99559.1 - 8.8 6.4 9.8 16 5.5 9.8 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Herpes_LMP1 PF05297.11 ETN99559.1 - 9.7 5.3 14.7 12 4.9 14.7 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Trypsin PF00089.26 ETN99561.1 - 3e-14 53.4 0.0 3.8e-14 53.0 0.0 1.1 1 0 0 1 1 1 1 Trypsin PMP22_Claudin PF00822.20 ETN99561.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family PUA PF01472.20 ETN99562.1 - 7.3e-16 57.9 0.3 1.5e-15 56.9 0.2 1.6 2 0 0 2 2 2 1 PUA domain SAM_2 PF07647.17 ETN99563.1 - 5.8e-08 32.7 0.1 1.2e-07 31.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETN99563.1 - 5.5e-05 23.5 0.2 0.00012 22.4 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_KSR1 PF13543.6 ETN99563.1 - 0.0029 17.7 0.8 0.0029 17.7 0.8 2.7 1 1 2 3 3 3 1 SAM like domain present in kinase suppressor RAS 1 AAA_32 PF13654.6 ETN99563.1 - 0.014 14.2 10.7 0.021 13.6 10.1 1.6 1 1 0 1 1 1 0 AAA domain GST_C PF00043.25 ETN99563.1 - 0.056 13.7 1.1 0.12 12.6 0.2 2.1 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain LUC7 PF03194.15 ETN99563.1 - 0.21 11.2 10.8 0.2 11.3 10.0 1.3 1 1 0 1 1 1 0 LUC7 N_terminus dCache_2 PF08269.11 ETN99563.1 - 0.48 9.5 7.2 0.13 11.4 4.4 1.5 2 0 0 2 2 2 0 Cache domain GrpE PF01025.19 ETN99563.1 - 0.58 9.8 11.4 0.73 9.5 7.8 2.2 1 1 1 2 2 2 0 GrpE TBCC_N PF16752.5 ETN99563.1 - 1.5 9.3 11.5 2.6 8.5 9.8 2.3 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF948 PF06103.11 ETN99563.1 - 1.5 9.1 3.7 16 5.9 0.8 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ETN99563.1 - 2.6 8.1 9.3 2.4 8.2 3.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Colicin-DNase PF12639.7 ETN99563.1 - 3.4 8.5 7.3 0.94 10.3 2.8 2.2 2 1 0 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin Exonuc_VII_L PF02601.15 ETN99563.1 - 3.9 7.0 7.6 5.1 6.6 7.6 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit Syntaxin-6_N PF09177.11 ETN99563.1 - 5.7 7.6 10.3 3 8.5 2.7 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal TFIIA PF03153.13 ETN99565.1 - 0.054 13.5 28.7 0.061 13.3 28.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Trypan_PARP PF05887.11 ETN99565.1 - 1.9 8.5 6.6 1.2 9.2 3.8 2.0 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF4551 PF15087.6 ETN99565.1 - 2.6 6.8 19.6 3.3 6.5 19.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GREB1 PF15782.5 ETN99565.1 - 6.2 3.8 25.7 7.3 3.6 25.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Choline_sulf_C PF12411.8 ETN99567.1 - 0.0034 17.1 0.2 0.055 13.3 0.1 2.2 2 0 0 2 2 2 1 Choline sulfatase enzyme C terminal DUF4653 PF15546.6 ETN99567.1 - 0.074 12.7 1.2 0.11 12.0 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) V-ATPase_H_N PF03224.14 ETN99568.1 - 0.0096 15.2 0.8 0.013 14.8 0.8 1.2 1 0 0 1 1 1 1 V-ATPase subunit H RTP1_C1 PF10363.9 ETN99568.1 - 0.036 14.3 0.1 0.12 12.5 0.1 1.8 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 TSR PF18487.1 ETN99568.1 - 0.41 10.9 6.3 1 9.6 0.1 3.2 3 0 0 3 3 3 0 Thrombospondin type 1 repeat DUF326 PF03860.16 ETN99568.1 - 3.8 7.6 10.4 4.1 7.5 0.8 3.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF326) WD40 PF00400.32 ETN99570.1 - 0.00025 21.8 0.7 0.00093 20.0 0.7 2.1 1 1 0 1 1 1 1 WD domain, G-beta repeat CUE PF02845.16 ETN99573.1 - 0.015 15.0 0.1 0.033 13.9 0.1 1.5 1 0 0 1 1 1 0 CUE domain CcdA PF07362.12 ETN99573.1 - 0.32 11.5 2.1 1.4 9.4 0.3 2.3 2 0 0 2 2 2 0 Post-segregation antitoxin CcdA Dna2 PF08696.11 ETN99574.1 - 0.034 14.0 0.9 0.19 11.5 0.0 2.6 3 0 0 3 3 3 0 DNA replication factor Dna2 Ribosomal_L22 PF00237.19 ETN99574.1 - 0.066 13.5 0.6 0.22 11.8 0.6 1.9 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e Dynamin_N PF00350.23 ETN99574.1 - 0.5 10.4 5.2 2.3 8.2 5.0 2.1 1 1 0 1 1 1 0 Dynamin family Kelch_2 PF07646.15 ETN99575.1 - 8.2e-07 28.8 2.5 0.0026 17.7 0.2 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETN99575.1 - 0.0019 18.4 0.7 0.51 10.7 0.3 2.8 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETN99575.1 - 0.0055 16.7 0.5 0.21 11.6 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99575.1 - 0.01 15.4 2.1 0.018 14.6 0.2 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETN99575.1 - 0.049 13.6 0.9 1.5 8.9 0.4 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETN99575.1 - 0.13 12.5 0.0 0.79 10.1 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain zf-TRAF PF02176.18 ETN99576.1 - 3.2e-08 34.1 3.2 6.2e-08 33.2 3.2 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger FapA PF03961.13 ETN99576.1 - 0.0024 16.6 6.2 0.0025 16.5 6.2 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A Val_tRNA-synt_C PF10458.9 ETN99576.1 - 0.022 15.0 3.1 0.022 15.0 3.1 2.5 2 1 1 3 3 3 0 Valyl tRNA synthetase tRNA binding arm zf-TRAF_2 PF15965.5 ETN99576.1 - 0.027 14.9 1.4 0.055 13.9 1.4 1.4 1 0 0 1 1 1 0 TRAF-like zinc-finger DivIC PF04977.15 ETN99576.1 - 0.028 14.2 1.1 0.028 14.2 1.1 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF1192 PF06698.11 ETN99576.1 - 0.05 13.7 1.5 9.4 6.4 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) DUF334 PF03904.13 ETN99576.1 - 0.14 11.7 12.5 0.18 11.3 12.4 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF334) SlyX PF04102.12 ETN99576.1 - 0.65 10.7 3.9 6.8 7.4 0.2 2.4 1 1 1 2 2 2 0 SlyX MAP17 PF15807.5 ETN99577.1 - 0.0096 16.2 0.8 0.022 15.0 0.0 1.8 1 1 1 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Na_Ca_ex PF01699.24 ETN99577.1 - 0.03 14.3 0.1 0.041 13.8 0.1 1.1 1 0 0 1 1 1 0 Sodium/calcium exchanger protein DUF4615 PF15393.6 ETN99577.1 - 0.035 14.7 0.4 0.096 13.3 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4615) DUF3149 PF11346.8 ETN99577.1 - 0.62 9.7 2.4 3.1 7.5 2.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3149) Glycophorin_A PF01102.18 ETN99577.1 - 7.9 6.8 8.3 0.42 10.9 0.1 2.2 1 1 1 2 2 2 0 Glycophorin A DUF3439 PF11921.8 ETN99577.1 - 8.5 6.4 12.3 0.099 12.6 4.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3439) WD40 PF00400.32 ETN99578.1 - 1.2e-16 60.7 14.8 2.4e-05 25.0 1.0 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99578.1 - 5.8e-09 36.1 0.0 0.0033 17.7 0.0 2.3 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99578.1 - 3.1e-05 22.8 0.6 0.13 10.9 0.1 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99578.1 - 3.3e-05 23.4 0.9 0.0007 19.0 0.4 2.3 1 1 1 2 2 2 1 WD40-like domain DUF4221 PF13970.6 ETN99578.1 - 0.051 13.1 0.5 0.096 12.2 0.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) XRN_N PF03159.18 ETN99579.1 - 4.6e-84 281.6 0.0 7.7e-84 280.9 0.0 1.4 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 ETN99579.1 - 1.2e-20 73.9 0.0 1.2e-20 73.9 0.0 2.0 3 0 0 3 3 3 1 Xrn1 helical domain MCM6_C PF18263.1 ETN99580.1 - 0.025 14.8 4.8 4 7.7 0.0 2.5 2 1 0 2 2 2 0 MCM6 C-terminal winged-helix domain DUF2973 PF11189.8 ETN99580.1 - 9.9 6.3 5.8 40 4.4 1.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2973) Kelch_6 PF13964.6 ETN99583.1 - 1.6e-07 31.4 0.7 0.00069 19.8 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETN99583.1 - 0.00014 21.3 0.2 0.21 11.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif RNA_pol_Rpb4 PF03874.16 ETN99583.1 - 0.0041 17.4 0.3 0.0062 16.9 0.3 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb4 PPR PF01535.20 ETN99588.1 - 1.7e-09 37.2 2.0 0.011 15.9 0.0 3.6 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.6 ETN99588.1 - 1.9e-09 37.5 4.2 0.036 14.2 0.0 3.6 2 1 0 3 3 3 3 PPR repeat family PPR_3 PF13812.6 ETN99588.1 - 4.5e-09 36.2 0.3 4.1e-05 23.6 0.0 3.0 1 1 2 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETN99588.1 - 1.9e-05 24.2 0.5 0.037 13.7 0.0 3.3 3 0 0 3 3 3 2 PPR repeat NACHT PF05729.12 ETN99590.1 - 2.2e-08 34.2 0.0 2.8e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETN99590.1 - 0.0011 19.5 0.0 0.0017 18.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain EF-hand_11 PF08976.11 ETN99590.1 - 0.011 16.6 0.1 0.015 16.2 0.1 1.2 1 0 0 1 1 1 0 EF-hand domain AAA PF00004.29 ETN99590.1 - 0.026 14.9 0.0 0.03 14.7 0.0 1.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETN99590.1 - 0.046 14.0 0.1 0.24 11.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain Kdo PF06293.14 ETN99591.1 - 0.0021 17.4 0.1 0.0044 16.4 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_phi PF04931.13 ETN99591.1 - 1.1 7.3 28.2 0.031 12.4 21.4 1.7 2 0 0 2 2 2 0 DNA polymerase phi CDC45 PF02724.14 ETN99591.1 - 8.1 4.6 23.5 0.088 11.1 16.0 1.4 2 0 0 2 2 2 0 CDC45-like protein CobT PF06213.12 ETN99591.1 - 9 5.6 19.5 18 4.6 19.5 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 ETN99591.1 - 9.5 4.9 13.5 1.3 7.8 8.9 1.7 2 0 0 2 2 2 0 Presenilin Cep57_MT_bd PF06657.13 ETN99592.1 - 0.068 13.6 2.2 0.58 10.7 0.3 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4046 PF13255.6 ETN99592.1 - 0.85 10.2 3.3 0.55 10.8 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4046) SAM_1 PF00536.30 ETN99593.1 - 0.00016 22.0 0.0 0.00043 20.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN99593.1 - 0.0042 17.2 0.1 0.0078 16.3 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) NT5C PF06941.12 ETN99593.1 - 0.047 13.6 0.4 4.9 7.0 0.0 2.7 1 1 1 2 2 2 0 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) LRV_FeS PF05484.11 ETN99593.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 LRV protein FeS4 cluster CUB_2 PF02408.20 ETN99593.1 - 0.63 9.8 3.6 1.2 9.0 0.1 2.6 3 0 0 3 3 3 0 CUB-like domain SAM_1 PF00536.30 ETN99594.1 - 5.6e-07 29.9 0.6 1.1e-06 28.9 0.2 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETN99594.1 - 1.1e-05 25.5 0.5 2.9e-05 24.1 0.5 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETN99594.1 - 0.011 15.6 0.1 0.031 14.2 0.1 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Pkinase PF00069.25 ETN99595.1 - 1.1e-63 215.1 0.0 2.1e-63 214.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 ETN99595.1 - 1.7e-54 181.8 1.6 1.9e-20 72.7 0.0 4.8 5 0 0 5 5 5 3 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 ETN99595.1 - 1.9e-25 89.6 0.0 3.6e-25 88.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETN99595.1 - 7.2e-06 25.5 0.0 1.9e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Cupin_2 PF07883.11 ETN99595.1 - 0.0098 15.6 1.3 3 7.6 0.0 3.0 3 0 0 3 3 3 2 Cupin domain NifZ PF04319.13 ETN99595.1 - 0.069 12.9 0.1 0.21 11.4 0.1 1.8 1 0 0 1 1 1 0 NifZ domain Cupin_3 PF05899.12 ETN99595.1 - 0.095 12.4 0.6 0.46 10.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF861) FRQ PF09421.10 ETN99600.1 - 0.043 11.8 5.3 0.049 11.7 5.3 1.0 1 0 0 1 1 1 0 Frequency clock protein MDM31_MDM32 PF08118.11 ETN99600.1 - 0.35 9.5 3.6 0.39 9.3 3.6 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins Presenilin PF01080.17 ETN99600.1 - 0.78 8.4 6.1 0.92 8.2 6.1 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETN99600.1 - 0.99 8.1 6.0 0.99 8.1 6.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.6 ETN99600.1 - 2.6 7.7 6.6 3.5 7.3 6.6 1.3 1 0 0 1 1 1 0 FAM176 family Zip PF02535.22 ETN99600.1 - 3.3 6.8 5.1 3.4 6.8 5.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETN99600.1 - 6.9 5.9 9.9 9.7 5.4 9.9 1.3 1 0 0 1 1 1 0 NOA36 protein zf-TRAF PF02176.18 ETN99601.1 - 3.2e-05 24.5 0.7 3.2e-05 24.5 0.7 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETN99601.1 - 0.15 11.9 2.8 1.9 8.4 2.8 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) LMBR1 PF04791.16 ETN99601.1 - 0.28 10.0 2.0 0.29 10.0 2.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein ETRAMP PF09716.10 ETN99602.1 - 5.6 7.1 10.7 2.7e+02 1.7 10.7 2.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) GTPase_binding PF09027.10 ETN99603.1 - 0.021 14.8 0.1 0.039 14.0 0.1 1.4 1 0 0 1 1 1 0 GTPase binding DnaB PF00772.21 ETN99605.1 - 0.069 13.2 0.0 0.079 13.0 0.0 1.1 1 0 0 1 1 1 0 DnaB-like helicase N terminal domain Metallophos PF00149.28 ETN99606.1 - 6.3e-07 30.1 0.2 1e-06 29.4 0.0 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase WD40 PF00400.32 ETN99607.1 - 1.3e-69 228.4 28.0 1.7e-11 44.4 0.1 7.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99607.1 - 5.6e-33 113.1 0.2 0.0001 22.5 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99607.1 - 9.6e-15 54.7 0.1 0.0015 17.9 0.0 4.4 2 1 3 5 5 5 5 WD40-like domain eIF2A PF08662.11 ETN99607.1 - 2e-12 47.4 0.0 9.9e-06 25.6 0.0 3.3 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 ETN99607.1 - 1.3e-11 44.5 1.7 5.2e-05 22.9 0.1 3.3 1 1 1 2 2 2 2 PQQ-like domain PD40 PF07676.12 ETN99607.1 - 8.6e-11 41.5 6.1 3.1 7.9 0.0 6.5 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETN99607.1 - 3.4e-10 39.4 0.5 1 8.3 0.0 5.9 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Gmad1 PF10647.9 ETN99607.1 - 3.3e-07 30.3 0.0 0.3 10.8 0.0 5.1 1 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain Me-amine-dh_H PF06433.11 ETN99607.1 - 4.4e-07 29.1 0.0 0.084 11.7 0.0 3.8 3 1 1 4 4 4 2 Methylamine dehydrogenase heavy chain (MADH) DUF727 PF05303.12 ETN99607.1 - 7.1e-06 26.0 0.0 14 5.8 0.0 5.6 1 1 5 6 6 6 0 Protein of unknown function (DUF727) DUF5570 PF17731.1 ETN99607.1 - 3.5e-05 23.9 16.9 2.8 8.1 0.2 6.5 1 1 6 7 7 7 1 Family of unknown function (DUF5570) Frtz PF11768.8 ETN99607.1 - 5.4e-05 21.7 0.0 2.1 6.6 0.0 3.9 2 2 2 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 ETN99607.1 - 6.4e-05 21.6 2.0 0.11 11.1 0.1 3.1 1 1 3 4 4 4 4 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETN99607.1 - 0.00018 20.4 0.3 4.1 6.1 0.0 5.0 1 1 4 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETN99607.1 - 0.0014 18.3 15.7 20 5.0 0.1 6.8 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature CT_A_B PF02626.15 ETN99607.1 - 0.0032 17.1 0.4 6.6 6.3 0.0 3.8 2 1 2 4 4 4 1 Carboxyltransferase domain, subdomain A and B Tudor_RapA PF18337.1 ETN99607.1 - 0.0083 16.3 0.2 47 4.3 0.0 4.9 5 0 0 5 5 5 0 RapA N-terminal Tudor like domain DUF3509 PF12021.8 ETN99607.1 - 0.014 15.1 0.0 13 5.6 0.0 4.1 2 1 3 5 5 5 0 Protein of unknown function (DUF3509) PQQ PF01011.21 ETN99607.1 - 0.017 15.0 0.0 75 3.5 0.0 5.0 6 0 0 6 6 5 0 PQQ enzyme repeat DUF2799 PF10973.8 ETN99607.1 - 0.11 13.0 0.0 70 3.9 0.0 4.2 6 0 0 6 6 4 0 Protein of unknown function (DUF2799) IRF-3 PF10401.9 ETN99607.1 - 0.23 11.2 0.0 1.2e+02 2.3 0.0 4.1 3 2 2 5 5 5 0 Interferon-regulatory factor 3 Dehydrin PF00257.19 ETN99608.1 - 0.03 14.9 1.9 0.031 14.8 1.9 1.1 1 0 0 1 1 1 0 Dehydrin 6PF2K PF01591.18 ETN99609.1 - 0.003 16.9 2.3 0.003 16.9 2.3 1.0 1 0 0 1 1 1 1 6-phosphofructo-2-kinase DUF4890 PF16231.5 ETN99609.1 - 0.012 16.1 3.0 0.014 15.8 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4890) Pneumovirus_M2 PF06436.11 ETN99609.1 - 0.072 12.6 3.4 0.08 12.4 3.4 1.2 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) DUF5345 PF17280.2 ETN99609.1 - 0.7 9.9 3.0 0.64 10.0 1.6 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5345) CHASE9 PF17153.4 ETN99610.1 - 0.0054 16.9 1.2 0.0079 16.3 1.2 1.2 1 0 0 1 1 1 1 Periplasmic sensor domain, extracellular WD40 PF00400.32 ETN99611.1 - 2.4e-32 110.4 7.0 7.4e-09 36.1 0.2 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99611.1 - 2.7e-17 62.9 0.2 5.9e-05 23.3 0.0 3.8 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99611.1 - 1.4e-05 24.0 0.3 0.092 11.4 0.0 3.7 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETN99611.1 - 3.4e-05 23.0 0.0 0.49 9.3 0.0 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETN99611.1 - 7.3e-05 22.6 0.0 17 5.5 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETN99611.1 - 0.00092 18.6 0.8 0.0085 15.5 0.8 1.9 1 1 0 1 1 1 1 WD40-like domain Coatomer_WDAD PF04053.14 ETN99611.1 - 0.0023 17.1 0.1 0.27 10.3 0.0 2.1 1 1 0 2 2 2 2 Coatomer WD associated region DUF5570 PF17731.1 ETN99611.1 - 0.0023 18.0 0.2 0.86 9.7 0.0 3.1 1 1 2 3 3 3 1 Family of unknown function (DUF5570) PQQ PF01011.21 ETN99611.1 - 0.006 16.4 0.0 14 5.8 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETN99611.1 - 0.013 14.4 0.2 5.6 5.8 0.0 3.1 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain 120_Rick_ant PF12574.8 ETN99611.1 - 0.033 13.4 0.0 0.042 13.0 0.0 1.2 1 0 0 1 1 1 0 120 KDa Rickettsia surface antigen Cu2_monoox_C PF03712.15 ETN99611.1 - 0.077 12.5 0.1 0.84 9.1 0.0 2.1 1 1 1 2 2 2 0 Copper type II ascorbate-dependent monooxygenase, C-terminal domain Cytochrom_D1 PF02239.16 ETN99611.1 - 0.1 11.1 0.0 0.38 9.2 0.0 1.7 1 1 1 2 2 2 0 Cytochrome D1 heme domain TPH PF13868.6 ETN99612.1 - 3.9e-28 98.0 143.4 3.9e-28 98.0 143.4 4.0 2 1 1 3 3 3 1 Trichohyalin-plectin-homology domain Pkinase PF00069.25 ETN99613.1 - 1.1e-09 38.1 0.0 1.1e-09 38.1 0.0 2.2 2 1 0 2 2 1 1 Protein kinase domain Merozoite_SPAM PF07133.11 ETN99613.1 - 0.00079 19.5 16.6 0.00079 19.5 16.6 2.2 2 0 0 2 2 2 1 Merozoite surface protein (SPAM) Presenilin PF01080.17 ETN99613.1 - 0.016 14.0 11.2 0.019 13.8 11.2 1.1 1 0 0 1 1 1 0 Presenilin SR-25 PF10500.9 ETN99613.1 - 0.037 13.6 17.3 0.054 13.1 17.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CCSAP PF15748.5 ETN99613.1 - 0.095 12.9 16.8 0.13 12.4 16.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Connexin PF00029.19 ETN99613.1 - 0.11 12.3 12.2 0.052 13.3 5.8 2.1 2 0 0 2 2 2 0 Connexin DUF2956 PF11169.8 ETN99613.1 - 0.23 11.7 10.8 0.13 12.5 5.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) AIF_C PF14721.6 ETN99613.1 - 0.39 11.1 10.5 0.25 11.7 3.1 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SLC12 PF03522.15 ETN99613.1 - 0.43 9.6 11.1 0.55 9.2 11.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 MAP17 PF15807.5 ETN99613.1 - 0.98 9.7 0.0 0.98 9.7 0.0 3.4 1 1 2 3 3 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Apis_Csd PF11671.8 ETN99613.1 - 2.1 8.4 10.1 0.19 11.7 1.8 2.2 2 0 0 2 2 2 0 Complementary sex determiner protein PA26 PF04636.13 ETN99613.1 - 2.4 7.0 11.6 3.4 6.5 11.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) BSMAP PF12280.8 ETN99613.1 - 3.2 7.9 9.9 0.42 10.8 1.7 2.1 1 1 1 2 2 2 0 Brain specific membrane anchored protein Hid1 PF12722.7 ETN99613.1 - 3.5 5.6 14.7 4.3 5.4 14.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Cytomega_UL84 PF06284.11 ETN99613.1 - 3.9 5.8 5.5 6.7 5.0 5.5 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein CSG2 PF16965.5 ETN99613.1 - 6.2 5.7 7.5 11 4.9 7.5 1.3 1 1 0 1 1 1 0 Ceramide synthase regulator Vfa1 PF08432.10 ETN99613.1 - 6.5 7.1 29.4 0.081 13.2 15.6 2.1 1 1 1 2 2 2 0 AAA-ATPase Vps4-associated protein 1 ATP-synt_E PF05680.12 ETN99613.1 - 8.9 6.7 17.9 3.1 8.2 12.6 2.2 2 0 0 2 2 2 0 ATP synthase E chain Metallothio_11 PF02066.15 ETN99614.1 - 0.026 14.7 0.8 8.2 6.7 0.0 2.5 2 0 0 2 2 2 0 Metallothionein family 11 TFIIF_beta PF02270.15 ETN99614.1 - 0.12 12.5 1.1 1.3 9.3 0.0 3.0 4 0 0 4 4 4 0 TFIIF, beta subunit HTH domain RepB-RCR_reg PF10723.9 ETN99614.1 - 0.35 10.8 1.5 29 4.7 0.4 2.5 2 0 0 2 2 2 0 Replication regulatory protein RepB EssA PF10661.9 ETN99615.1 - 0.051 13.4 12.5 0.15 11.9 4.5 2.2 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA DUF1002 PF06207.11 ETN99615.1 - 1.4 8.4 7.7 0.23 11.0 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) RE_MjaI PF09568.10 ETN99616.1 - 0.017 14.9 11.1 0.023 14.5 3.3 2.3 1 1 1 2 2 2 0 MjaI restriction endonuclease DUF3666 PF12408.8 ETN99616.1 - 0.033 13.4 0.3 0.12 11.7 0.1 2.0 2 0 0 2 2 2 0 Ribose-5-phosphate isomerase Toxin-JAB1 PF15659.6 ETN99616.1 - 0.057 13.8 0.2 0.13 12.6 0.2 1.6 1 0 0 1 1 1 0 JAB-like toxin 1 Mer2 PF09074.10 ETN99616.1 - 0.58 9.9 14.3 68 3.2 14.5 2.1 1 1 0 1 1 1 0 Mer2 Lge1 PF11488.8 ETN99616.1 - 1.1 9.5 7.2 0.38 11.0 2.4 2.6 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 Glu-tRNAGln PF02686.15 ETN99616.1 - 5.4 7.4 7.0 0.73 10.2 0.9 2.6 3 0 0 3 3 3 0 Glu-tRNAGln amidotransferase C subunit WD40 PF00400.32 ETN99617.1 - 4.7e-06 27.2 10.6 5.2e-06 27.1 0.3 4.1 3 2 1 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99617.1 - 0.00095 19.4 0.5 0.046 14.0 0.1 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99617.1 - 0.009 14.7 1.0 0.015 13.9 0.9 1.5 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETN99617.1 - 0.017 13.9 0.3 0.033 12.9 0.1 1.4 1 1 0 1 1 1 0 Nup133 N terminal like eIF2A PF08662.11 ETN99617.1 - 0.022 14.6 0.5 0.053 13.4 0.1 1.8 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A ENOD93 PF03386.14 ETN99617.1 - 0.1 12.5 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 Early nodulin 93 ENOD93 protein PUB PF09409.10 ETN99618.1 - 0.0049 16.8 1.0 0.031 14.2 1.0 2.0 1 1 0 1 1 1 1 PUB domain DUF2207 PF09972.9 ETN99619.1 - 0.18 10.5 1.4 0.24 10.1 1.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) PHP PF02811.19 ETN99620.1 - 0.15 12.4 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 PHP domain WD40 PF00400.32 ETN99622.1 - 2.5e-16 59.8 11.1 1.6e-07 31.9 2.1 3.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN99622.1 - 1.2e-06 27.5 1.0 0.0082 14.8 0.2 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99622.1 - 1.3e-05 25.4 0.1 0.39 11.0 0.1 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99622.1 - 0.00031 20.2 0.5 0.0008 18.8 0.4 1.6 1 1 1 2 2 2 2 WD40-like domain Colicin_immun PF09204.10 ETN99623.1 - 0.87 10.2 6.0 0.62 10.6 0.3 2.1 1 1 1 2 2 2 0 Bacterial self-protective colicin-like immunity WD40 PF00400.32 ETN99624.1 - 1.5e-10 41.5 1.5 8.7e-05 23.2 0.1 2.8 2 2 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN99624.1 - 0.00019 20.2 0.0 0.078 11.6 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99624.1 - 0.008 16.4 0.1 0.96 9.8 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETN99624.1 - 0.04 12.7 0.2 1.4 7.6 0.1 2.0 1 1 1 2 2 2 0 Nup133 N terminal like Ytp1 PF10355.9 ETN99624.1 - 0.073 12.3 0.1 0.085 12.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (Ytp1) WD40 PF00400.32 ETN99626.1 - 1.3e-13 51.2 10.6 1.1e-07 32.4 1.2 2.8 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN99626.1 - 3.9e-06 25.8 2.0 0.00097 17.9 0.3 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99626.1 - 0.0021 18.3 0.1 0.019 15.3 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Fe_hyd_lg_C PF02906.14 ETN99627.1 - 1.9e-48 165.3 1.1 3.7e-48 164.3 1.1 1.5 1 0 0 1 1 1 1 Iron only hydrogenase large subunit, C-terminal domain HSA PF07529.13 ETN99627.1 - 0.067 13.5 3.8 2.6 8.4 0.1 2.8 2 0 0 2 2 2 0 HSA DUF4868 PF16162.5 ETN99629.1 - 0.34 10.8 26.5 2 8.3 1.1 3.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4868) DUF4573 PF15140.6 ETN99629.1 - 0.73 9.6 6.0 3.7 7.3 6.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4573) Mrpl_C PF18502.1 ETN99630.1 - 0.00072 19.8 0.8 0.0016 18.7 0.8 1.6 1 0 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain tRNA-synt_His PF13393.6 ETN99630.1 - 0.033 13.5 0.1 0.041 13.2 0.1 1.1 1 0 0 1 1 1 0 Histidyl-tRNA synthetase cNMP_binding PF00027.29 ETN99631.1 - 4.5e-10 39.5 0.0 1.4e-08 34.7 0.0 2.5 2 1 0 3 3 3 1 Cyclic nucleotide-binding domain FAM199X PF15814.5 ETN99631.1 - 0.017 14.2 7.4 0.019 14.0 7.4 1.2 1 0 0 1 1 1 0 Protein family FAM199X CBM39 PF15886.5 ETN99631.1 - 0.049 13.5 0.0 0.069 13.1 0.0 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 32) ATF7IP_BD PF16788.5 ETN99631.1 - 0.17 12.0 3.0 0.2 11.8 3.0 1.2 1 0 0 1 1 1 0 ATF-interacting protein binding domain DUF515 PF04415.12 ETN99631.1 - 0.36 9.2 9.3 0.39 9.1 9.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Atrophin-1 PF03154.15 ETN99631.1 - 2.1 6.5 7.2 2.5 6.3 7.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family Herpes_capsid PF06112.11 ETN99631.1 - 4.9 7.2 12.9 9.6 6.2 12.9 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SSP160 PF06933.11 ETN99631.1 - 8 4.5 19.7 9 4.4 18.7 1.5 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 MYT1 PF08474.11 ETN99633.1 - 0.0028 17.6 1.6 0.0028 17.6 1.6 1.0 1 0 0 1 1 1 1 Myelin transcription factor 1 Myc_target_1 PF15179.6 ETN99633.1 - 0.035 14.0 0.4 0.045 13.7 0.4 1.1 1 0 0 1 1 1 0 Myc target protein 1 Methyltrn_RNA_2 PF04013.12 ETN99633.1 - 0.069 12.8 0.4 0.075 12.7 0.4 1.0 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase STN PF07660.14 ETN99633.1 - 0.092 12.6 0.2 0.19 11.5 0.0 1.6 2 0 0 2 2 2 0 Secretin and TonB N terminus short domain HEAT PF02985.22 ETN99635.1 - 3.1e-06 27.0 0.0 0.55 10.6 0.0 5.2 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 ETN99635.1 - 0.00017 21.9 0.0 26 5.3 0.0 4.5 3 1 1 4 4 4 0 HEAT repeats MMS19_C PF12460.8 ETN99635.1 - 0.0029 16.8 4.7 0.022 13.9 3.8 2.6 1 1 0 1 1 1 1 RNAPII transcription regulator C-terminal HEXIM PF15313.6 ETN99635.1 - 0.041 14.1 1.1 0.33 11.2 0.1 2.3 2 0 0 2 2 2 0 Hexamethylene bis-acetamide-inducible protein DUF1421 PF07223.11 ETN99635.1 - 0.048 13.5 0.2 0.64 9.9 0.0 2.6 3 0 0 3 3 3 0 UBA-like domain (DUF1421) DUF3944 PF13099.6 ETN99635.1 - 0.077 12.9 0.1 1.2 9.0 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3944) RTP1_C1 PF10363.9 ETN99635.1 - 0.1 12.8 3.0 1.2 9.3 0.1 3.4 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 DNA_pol3_gamma3 PF12169.8 ETN99635.1 - 0.13 12.1 0.2 12 5.8 0.0 3.3 3 1 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III HEAT_EZ PF13513.6 ETN99635.1 - 0.2 12.2 0.0 47 4.6 0.0 4.1 6 0 0 6 6 6 0 HEAT-like repeat Peptidase_C14 PF00656.22 ETN99636.1 - 0.0014 18.6 0.0 0.0035 17.3 0.0 1.5 1 1 0 1 1 1 1 Caspase domain RUN PF02759.19 ETN99637.1 - 0.044 13.7 1.1 0.056 13.4 0.5 1.4 1 1 0 1 1 1 0 RUN domain Presenilin PF01080.17 ETN99638.1 - 1.6 7.4 5.6 1.9 7.1 5.6 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETN99638.1 - 2.4 9.2 8.9 0.66 11.0 1.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF823 PF05689.11 ETN99639.1 - 0.031 14.1 1.1 0.043 13.6 1.1 1.3 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF823) DUF2911 PF11138.8 ETN99639.1 - 0.098 12.5 2.1 0.19 11.6 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2911) DUF1664 PF07889.12 ETN99639.1 - 0.3 11.1 4.7 0.88 9.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) WD40 PF00400.32 ETN99640.1 - 8.4e-11 42.3 1.0 9.7e-05 23.1 0.2 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN99640.1 - 0.0014 17.4 0.4 0.78 8.3 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Rieske_2 PF13806.6 ETN99640.1 - 0.038 13.9 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Rieske-like [2Fe-2S] domain NinF PF05810.12 ETN99642.1 - 0.082 12.8 2.7 0.18 11.7 1.4 2.0 1 1 1 2 2 2 0 NinF protein zf-C3HC4_2 PF13923.6 ETN99642.1 - 0.13 12.1 8.0 0.57 10.1 5.2 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) BTB_2 PF02214.22 ETN99646.1 - 0.15 12.4 4.0 0.14 12.5 2.4 1.7 1 1 1 2 2 2 0 BTB/POZ domain DUF4239 PF14023.6 ETN99646.1 - 0.23 11.2 1.9 0.3 10.8 1.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4239) APG6_N PF17675.1 ETN99646.1 - 0.67 10.5 14.7 0.85 10.1 14.7 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF641 PF04859.12 ETN99646.1 - 0.81 10.0 12.0 33 4.8 12.0 2.3 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Exonuc_VII_L PF02601.15 ETN99646.1 - 2.1 7.9 8.0 2.3 7.7 8.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2663 PF10864.8 ETN99647.1 - 0.21 12.0 5.3 0.051 14.0 1.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) GET2 PF08690.10 ETN99648.1 - 0.091 12.4 12.7 0.11 12.2 12.7 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 VIT1 PF01988.19 ETN99649.1 - 0.44 10.4 1.3 0.51 10.2 1.3 1.2 1 0 0 1 1 1 0 VIT family RabGAP-TBC PF00566.18 ETN99650.1 - 2.7e-20 73.0 0.7 3e-20 72.8 0.7 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain PPR_2 PF13041.6 ETN99651.1 - 0.016 15.3 0.1 0.037 14.2 0.1 1.6 1 0 0 1 1 1 0 PPR repeat family Kelch_6 PF13964.6 ETN99652.1 - 1.6e-06 28.2 0.1 7.5e-05 22.9 0.0 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETN99652.1 - 1.2e-05 25.2 0.1 5.9e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99652.1 - 1.8e-05 24.2 0.0 0.00017 21.1 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETN99652.1 - 0.00018 21.7 0.0 0.0013 19.0 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN99652.1 - 0.0036 17.2 0.1 0.049 13.6 0.1 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETN99652.1 - 0.11 12.6 0.1 2.7 8.1 0.1 2.3 2 0 0 2 2 2 0 Kelch motif OmpH PF03938.14 ETN99652.1 - 0.2 12.0 4.9 0.32 11.3 4.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) WD40 PF00400.32 ETN99653.1 - 1.2e-28 98.7 3.0 3.2e-07 30.9 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99653.1 - 6.1e-16 58.5 0.1 0.0022 18.2 0.0 4.8 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99653.1 - 8.1e-08 31.4 1.1 0.031 12.9 0.1 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99653.1 - 6.5e-06 25.7 3.8 0.0006 19.2 0.3 2.9 2 1 1 3 3 3 2 WD40-like domain PQQ PF01011.21 ETN99653.1 - 0.00014 21.6 0.0 5.3 7.2 0.0 4.2 4 0 0 4 4 4 1 PQQ enzyme repeat Coatomer_WDAD PF04053.14 ETN99653.1 - 0.0039 16.3 0.2 0.0056 15.8 0.1 1.4 1 1 0 1 1 1 1 Coatomer WD associated region Me-amine-dh_H PF06433.11 ETN99653.1 - 0.0041 16.0 0.1 0.046 12.6 0.0 2.3 1 1 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) MIR PF02815.19 ETN99653.1 - 0.0086 15.9 0.0 1.5 8.6 0.0 2.6 2 1 0 2 2 2 1 MIR domain Nbas_N PF15492.6 ETN99653.1 - 0.038 13.3 0.2 0.43 9.9 0.0 2.4 3 0 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETN99653.1 - 0.057 13.0 0.0 1.7 8.2 0.0 1.9 1 1 1 2 2 2 0 PQQ-like domain DPPIV_N PF00930.21 ETN99653.1 - 0.058 12.1 0.1 16 4.1 0.0 3.1 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETN99653.1 - 2.8 8.0 6.3 1.4e+02 2.5 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Phtf-FEM1B_bdg PF12129.8 ETN99654.1 - 0.053 13.4 0.3 0.079 12.8 0.3 1.3 1 0 0 1 1 1 0 Male germ-cell putative homeodomain transcription factor rve_2 PF13333.6 ETN99655.1 - 0.022 15.0 0.4 0.31 11.3 0.3 2.3 1 1 0 1 1 1 0 Integrase core domain BIRC6 PF12356.8 ETN99655.1 - 0.04 13.4 0.0 0.049 13.0 0.0 1.2 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 YlbE PF14003.6 ETN99656.1 - 0.011 16.2 0.1 0.57 10.7 0.0 3.0 2 0 0 2 2 2 0 YlbE-like protein DUF2430 PF10353.9 ETN99656.1 - 0.065 13.6 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) DUF4485 PF14846.6 ETN99656.1 - 0.072 13.1 0.3 0.22 11.6 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4485) HLH PF00010.26 ETN99657.1 - 0.087 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain zf-TRAF PF02176.18 ETN99658.1 - 1.2e-05 25.9 7.7 4.5e-05 24.1 7.7 2.0 1 1 0 1 1 1 1 TRAF-type zinc finger YabA PF06156.13 ETN99658.1 - 0.011 16.3 4.4 0.028 15.0 4.4 1.7 1 0 0 1 1 1 0 Initiation control protein YabA HALZ PF02183.18 ETN99658.1 - 0.026 14.7 4.6 0.072 13.3 4.6 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Sina PF03145.16 ETN99658.1 - 1.5 8.8 11.9 0.4 10.6 5.3 2.5 1 1 0 2 2 2 0 Seven in absentia protein family zf-TRAF PF02176.18 ETN99659.1 - 1.8e-06 28.5 3.0 1.8e-06 28.5 3.0 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger EF-hand_2 PF09068.11 ETN99659.1 - 3.1 8.0 8.1 1.2 9.3 4.6 2.2 2 1 0 2 2 2 0 EF hand EVI2A PF05399.11 ETN99661.1 - 2.2 7.8 12.1 2.4 7.7 12.1 1.0 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) WD40 PF00400.32 ETN99662.1 - 5.8e-12 45.9 1.9 7.2e-05 23.5 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETN99662.1 - 0.027 13.1 0.3 2.9 6.4 0.2 2.3 1 1 2 3 3 3 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99662.1 - 0.094 13.0 0.0 18 5.7 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Ricin_B_lectin PF00652.22 ETN99662.1 - 0.14 12.4 1.8 0.22 11.8 1.8 1.2 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain DUF4979 PF16351.5 ETN99662.1 - 0.15 12.3 3.4 0.2 11.9 2.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4979) Flp_N PF03930.14 ETN99663.1 - 0.07 13.1 2.1 0.27 11.2 0.4 2.3 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus ArsR PF09824.9 ETN99664.1 - 0.015 14.9 0.1 0.11 12.0 0.0 2.2 2 0 0 2 2 2 0 ArsR transcriptional regulator Cofilin_ADF PF00241.20 ETN99665.1 - 0.003 17.3 0.4 0.0044 16.8 0.4 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein ETRAMP PF09716.10 ETN99665.1 - 0.0067 16.5 6.9 0.87 9.7 6.9 2.3 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF3810 PF12725.7 ETN99665.1 - 0.057 12.8 0.3 0.068 12.5 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) NACHT PF05729.12 ETN99666.1 - 3.1e-09 37.0 0.0 3.5e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETN99666.1 - 0.036 14.0 0.5 0.13 12.2 0.0 2.2 2 1 0 2 2 2 0 STI1 domain WD40 PF00400.32 ETN99667.1 - 1e-22 80.0 9.8 5.1e-08 33.4 1.0 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99667.1 - 1.1e-07 32.1 0.8 0.13 12.5 0.0 3.9 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99667.1 - 3.4e-07 29.3 1.7 0.026 13.2 0.2 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99667.1 - 0.081 12.2 6.6 0.12 11.7 1.1 2.6 2 1 1 3 3 3 0 WD40-like domain V-ATPase_G PF03179.15 ETN99667.1 - 0.23 12.0 13.3 0.22 12.0 10.1 2.2 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit FapA PF03961.13 ETN99667.1 - 5.2 5.6 11.4 6.3 5.3 11.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A EVI2A PF05399.11 ETN99668.1 - 0.017 14.7 0.3 0.025 14.2 0.3 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Kelch_1 PF01344.25 ETN99669.1 - 4.3e-07 29.4 1.5 8.9e-07 28.4 1.5 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 ETN99669.1 - 0.002 18.1 0.6 0.0053 16.7 0.6 1.7 1 0 0 1 1 1 1 Kelch motif Kelch_5 PF13854.6 ETN99669.1 - 0.0028 17.6 0.9 0.0028 17.6 0.9 2.1 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETN99669.1 - 0.0063 16.8 1.0 0.016 15.5 0.5 1.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETN99669.1 - 0.013 15.5 0.3 0.028 14.4 0.3 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN99669.1 - 0.051 13.9 2.3 0.074 13.4 0.8 2.1 2 1 0 2 2 2 0 Kelch motif DSL PF01414.19 ETN99670.1 - 2 8.7 10.7 3.9 7.8 0.4 2.6 2 0 0 2 2 2 0 Delta serrate ligand Ssl1 PF04056.14 ETN99672.1 - 0.064 13.1 1.3 1.3 8.8 0.1 2.5 2 0 0 2 2 2 0 Ssl1-like DNA_pol_E_B PF04042.16 ETN99676.1 - 0.0015 17.9 0.1 0.0021 17.4 0.1 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Symplekin_C PF12295.8 ETN99676.1 - 0.022 14.9 0.4 0.038 14.1 0.2 1.4 1 1 1 2 2 2 0 Symplekin tight junction protein C terminal DUF684 PF05075.14 ETN99677.1 - 0.013 14.5 1.1 0.014 14.4 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF684) DUF4488 PF14869.6 ETN99677.1 - 0.056 13.4 0.2 0.069 13.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4488) DUF4195 PF13836.6 ETN99678.1 - 0.0075 16.4 2.9 0.0092 16.1 2.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4195) MRI PF15325.6 ETN99678.1 - 6.4 7.9 9.2 15 6.7 4.5 2.0 1 1 1 2 2 2 0 Modulator of retrovirus infection PIN_12 PF16289.5 ETN99680.1 - 0.0065 17.0 5.7 0.0083 16.6 5.7 1.1 1 0 0 1 1 1 1 PIN domain Granin PF01271.17 ETN99680.1 - 0.0082 15.1 1.9 0.0099 14.8 1.9 1.0 1 0 0 1 1 1 1 Granin (chromogranin or secretogranin) Allexi_40kDa PF05549.11 ETN99680.1 - 0.0089 15.6 2.9 0.011 15.3 2.9 1.1 1 0 0 1 1 1 1 Allexivirus 40kDa protein Pex26 PF07163.12 ETN99680.1 - 0.019 14.3 3.2 0.022 14.1 3.2 1.1 1 0 0 1 1 1 0 Pex26 protein AbiH PF14253.6 ETN99680.1 - 0.024 14.5 5.0 0.026 14.4 5.0 1.1 1 0 0 1 1 1 0 Bacteriophage abortive infection AbiH Tfb4 PF03850.14 ETN99680.1 - 0.032 13.7 4.0 0.038 13.5 4.0 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 DDHD PF02862.17 ETN99680.1 - 0.24 11.5 4.6 0.6 10.2 3.4 1.7 1 1 1 2 2 2 0 DDHD domain SUIM_assoc PF16619.5 ETN99680.1 - 0.81 9.8 10.8 1.6 8.8 10.8 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF16 PF01519.16 ETN99680.1 - 3.4 8.2 13.5 6.5 7.3 13.5 1.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 CD36 PF01130.21 ETN99681.1 - 3e-46 157.9 6.9 4e-46 157.5 6.9 1.0 1 0 0 1 1 1 1 CD36 family Ank_3 PF13606.6 ETN99682.1 - 1.1e-07 31.5 0.1 0.0048 17.3 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETN99682.1 - 5.8e-07 29.9 0.3 8e-07 29.5 0.3 1.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETN99682.1 - 1.9e-05 25.1 0.1 2.4e-05 24.8 0.1 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETN99682.1 - 4.6e-05 23.6 0.2 0.00011 22.4 0.1 1.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETN99682.1 - 0.0072 16.7 0.2 0.24 11.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat INSC_LBD PF16748.5 ETN99682.1 - 0.056 12.9 0.1 0.11 11.9 0.0 1.5 2 0 0 2 2 2 0 Inscuteable LGN-binding domain NOA36 PF06524.12 ETN99683.1 - 0.0096 15.3 11.4 0.011 15.1 11.4 1.1 1 0 0 1 1 1 1 NOA36 protein Alpha-mann_mid PF09261.11 ETN99684.1 - 0.03 14.5 0.6 0.036 14.2 0.6 1.1 1 0 0 1 1 1 0 Alpha mannosidase middle domain RRN3 PF05327.11 ETN99685.1 - 0.046 12.3 9.6 0.045 12.3 9.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 ETN99685.1 - 0.1 12.0 18.2 0.11 11.8 18.2 1.1 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 ETN99685.1 - 0.44 9.1 21.7 0.48 9.0 21.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GET2 PF08690.10 ETN99685.1 - 0.85 9.2 5.7 1.5 8.4 5.7 1.4 1 1 0 1 1 1 0 GET complex subunit GET2 CCSAP PF15748.5 ETN99685.1 - 2 8.6 11.4 2.2 8.4 11.4 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DNA_pol_phi PF04931.13 ETN99685.1 - 2.1 6.4 25.5 2.2 6.3 25.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 ETN99685.1 - 2.3 7.6 24.4 2.7 7.4 24.4 1.2 1 0 0 1 1 1 0 SDA1 PGA2 PF07543.12 ETN99685.1 - 2.5 8.1 14.9 4.1 7.4 14.9 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Vfa1 PF08432.10 ETN99685.1 - 2.9 8.2 13.0 3.9 7.8 13.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Tim54 PF11711.8 ETN99685.1 - 3 6.6 9.0 3.3 6.4 9.0 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 ETN99685.1 - 3.3 5.9 21.0 3.6 5.8 21.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 ETN99685.1 - 4.3 5.7 28.4 4.9 5.5 28.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Kelch_2 PF07646.15 ETN99687.1 - 6.3e-05 22.8 2.7 0.22 11.5 0.1 4.7 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETN99687.1 - 0.00019 21.4 0.7 0.0036 17.3 0.0 2.8 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99687.1 - 0.00058 19.4 0.4 0.008 15.7 0.1 2.8 3 0 0 3 3 3 1 Kelch motif TLD PF07534.16 ETN99687.1 - 0.028 14.7 1.2 0.057 13.6 0.3 2.0 1 1 1 2 2 2 0 TLD Kelch_5 PF13854.6 ETN99687.1 - 0.044 13.8 0.2 2.6 8.1 0.1 3.3 3 0 0 3 3 3 0 Kelch motif PI3K_P85_iSH2 PF16454.5 ETN99688.1 - 0.011 15.3 12.0 0.013 15.1 12.0 1.1 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Csm1_N PF18504.1 ETN99688.1 - 0.022 15.1 8.5 0.022 15.1 8.5 1.9 1 1 1 2 2 2 0 Csm1 N-terminal domain DUSP PF06337.12 ETN99688.1 - 0.96 10.1 7.7 1.2 9.8 7.7 1.2 1 0 0 1 1 1 0 DUSP domain zf-CpG_bind_C PF12269.8 ETN99688.1 - 2.6 7.8 12.2 2.7 7.7 12.2 1.0 1 0 0 1 1 1 0 CpG binding protein zinc finger C terminal domain CHD5 PF04420.14 ETN99688.1 - 3.3 7.6 8.5 12 5.7 8.5 1.9 1 1 0 1 1 1 0 CHD5-like protein DUF4407 PF14362.6 ETN99688.1 - 9.7 5.4 9.2 9.5 5.5 9.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RsgA_GTPase PF03193.16 ETN99689.1 - 2.5e-05 24.2 1.3 0.00039 20.4 1.3 2.2 1 1 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ETN99689.1 - 7.2e-05 23.3 0.1 0.00014 22.4 0.1 1.4 1 0 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 ETN99689.1 - 9.2e-05 22.5 0.3 0.00035 20.6 0.3 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase T2SSE PF00437.20 ETN99689.1 - 0.0017 17.5 0.1 0.002 17.2 0.1 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF815 PF05673.13 ETN99689.1 - 0.0042 16.3 0.1 0.0063 15.7 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) PhoH PF02562.16 ETN99689.1 - 0.0066 15.9 0.3 0.0094 15.4 0.3 1.2 1 0 0 1 1 1 1 PhoH-like protein AAA_19 PF13245.6 ETN99689.1 - 0.0079 16.5 0.1 0.011 16.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ETN99689.1 - 0.0084 15.8 0.1 0.019 14.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_7 PF12775.7 ETN99689.1 - 0.011 15.3 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region Dynamin_N PF00350.23 ETN99689.1 - 0.019 15.0 2.7 0.57 10.2 0.1 2.5 2 1 1 3 3 3 0 Dynamin family Septin PF00735.18 ETN99689.1 - 0.02 14.2 0.2 0.032 13.5 0.2 1.3 1 0 0 1 1 1 0 Septin IstB_IS21 PF01695.17 ETN99689.1 - 0.021 14.6 0.2 0.1 12.4 0.2 1.9 1 1 1 2 2 2 0 IstB-like ATP binding protein AAA_23 PF13476.6 ETN99689.1 - 0.032 14.7 0.4 0.049 14.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETN99689.1 - 0.032 13.9 0.1 0.042 13.6 0.1 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETN99689.1 - 0.058 13.6 0.5 0.09 13.0 0.5 1.5 1 1 0 1 1 1 0 AAA domain MCM PF00493.23 ETN99689.1 - 0.064 12.3 0.1 0.095 11.8 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain FtsK_SpoIIIE PF01580.18 ETN99689.1 - 0.065 12.6 0.1 0.1 11.9 0.1 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family Adeno_IVa2 PF02456.15 ETN99689.1 - 0.074 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein Zeta_toxin PF06414.12 ETN99689.1 - 0.09 12.0 0.1 0.13 11.5 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin RNase_T PF00929.24 ETN99691.1 - 5.6e-07 30.3 0.0 1.1e-06 29.3 0.0 1.5 1 0 0 1 1 1 1 Exonuclease DUF5051 PF16473.5 ETN99691.1 - 0.072 13.1 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 3' exoribonuclease, RNase T-like Trypan_PARP PF05887.11 ETN99691.1 - 0.4 10.7 5.2 0.61 10.1 5.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) RNA_pol_Rpb4 PF03874.16 ETN99692.1 - 0.12 12.7 12.1 0.66 10.3 12.1 2.0 1 1 0 1 1 1 0 RNA polymerase Rpb4 Zip PF02535.22 ETN99692.1 - 0.29 10.3 1.2 0.31 10.2 1.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TMEM232 PF15877.5 ETN99693.1 - 0.14 11.1 0.2 0.19 10.7 0.2 1.1 1 0 0 1 1 1 0 Transmembrane protein family 232 Zip PF02535.22 ETN99694.1 - 0.19 10.9 0.8 0.24 10.6 0.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter O-antigen_lig PF13425.6 ETN99694.1 - 0.32 9.7 9.1 0.35 9.6 9.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein zf-TRAF PF02176.18 ETN99696.1 - 9.4e-07 29.4 1.0 2.2e-06 28.2 1.0 1.7 1 0 0 1 1 1 1 TRAF-type zinc finger YabA PF06156.13 ETN99696.1 - 0.0046 17.6 7.4 0.0046 17.6 7.4 2.4 1 1 1 2 2 2 1 Initiation control protein YabA CENP-F_leu_zip PF10473.9 ETN99696.1 - 0.0068 16.4 22.2 0.01 15.9 19.7 2.2 2 0 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TSC22 PF01166.18 ETN99696.1 - 0.014 15.7 4.1 0.014 15.7 4.1 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family Sina PF03145.16 ETN99696.1 - 0.025 14.5 6.2 0.04 13.9 5.5 1.6 1 1 0 1 1 1 0 Seven in absentia protein family Atg14 PF10186.9 ETN99696.1 - 0.031 13.4 11.4 0.042 12.9 11.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 ETN99696.1 - 0.11 12.0 21.5 0.15 11.5 21.5 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF4407 PF14362.6 ETN99696.1 - 0.32 10.3 7.6 0.45 9.8 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GIDA_assoc PF13932.6 ETN99696.1 - 0.46 10.6 10.9 0.61 10.2 10.9 1.2 1 0 0 1 1 1 0 GidA associated domain LMBR1 PF04791.16 ETN99696.1 - 2.8 6.7 5.8 3 6.7 5.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein bZIP_1 PF00170.21 ETN99696.1 - 5.4 7.2 12.0 0.22 11.7 3.9 2.9 2 2 0 2 2 2 0 bZIP transcription factor DUF3450 PF11932.8 ETN99696.1 - 8.4 5.6 15.8 4.3 6.6 13.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Cast PF10174.9 ETN99700.1 - 0.0051 15.1 4.0 0.0057 15.0 4.0 1.0 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Ribosomal_L50 PF10501.9 ETN99700.1 - 0.0053 16.9 1.0 0.0075 16.4 0.5 1.5 2 0 0 2 2 2 1 Ribosomal subunit 39S DUF148 PF02520.17 ETN99700.1 - 0.0063 16.6 6.1 0.23 11.6 4.4 2.2 1 1 1 2 2 2 1 Domain of unknown function DUF148 FlaC_arch PF05377.11 ETN99700.1 - 0.0068 16.8 6.5 0.88 10.0 2.1 2.4 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) DUF2063 PF09836.9 ETN99700.1 - 0.0086 16.3 0.0 0.01 16.1 0.0 1.2 1 0 0 1 1 1 1 Putative DNA-binding domain Effector_1 PF04518.12 ETN99700.1 - 0.0096 15.1 1.6 0.011 14.9 1.6 1.1 1 0 0 1 1 1 1 Effector from type III secretion system FlxA PF14282.6 ETN99700.1 - 0.016 15.2 1.7 0.032 14.2 1.7 1.5 1 0 0 1 1 1 0 FlxA-like protein RasGAP_C PF03836.15 ETN99700.1 - 0.026 14.7 2.1 0.03 14.5 2.1 1.1 1 0 0 1 1 1 0 RasGAP C-terminus Cauli_DNA-bind PF03310.13 ETN99700.1 - 0.032 14.3 4.9 2.3 8.3 1.9 2.1 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein FOXP-CC PF16159.5 ETN99700.1 - 0.13 12.9 0.1 0.26 12.0 0.1 1.5 1 0 0 1 1 1 0 FOXP coiled-coil domain HEAT PF02985.22 ETN99701.1 - 8.7e-07 28.7 0.0 0.0058 16.8 0.0 2.8 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETN99701.1 - 0.001 19.4 0.0 0.013 15.9 0.0 2.0 1 1 1 2 2 2 2 HEAT repeats CLASP_N PF12348.8 ETN99701.1 - 0.0011 18.6 0.4 0.0024 17.5 0.2 1.6 1 1 0 1 1 1 1 CLASP N terminal Cnd1 PF12717.7 ETN99701.1 - 0.0014 18.7 5.0 0.008 16.2 0.2 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Cas_Csm6 PF09659.10 ETN99701.1 - 0.015 14.1 3.4 0.018 13.8 3.4 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) HEAT_EZ PF13513.6 ETN99701.1 - 0.033 14.7 0.0 0.21 12.1 0.0 2.1 1 1 1 2 2 2 0 HEAT-like repeat HAUS6_N PF14661.6 ETN99701.1 - 0.035 13.7 3.2 1.2 8.6 0.2 2.8 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 6 N-terminus Inhibitor_I9 PF05922.16 ETN99701.1 - 0.054 14.2 0.0 0.08 13.6 0.0 1.6 1 1 0 1 1 1 0 Peptidase inhibitor I9 AAA_lid_7 PF17867.1 ETN99701.1 - 0.068 13.4 0.1 0.3 11.3 0.1 1.8 1 1 1 2 2 2 0 Midasin AAA lid domain EF-hand_1 PF00036.32 ETN99702.1 - 0.012 15.1 0.0 0.03 13.9 0.0 1.7 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 ETN99702.1 - 0.15 12.1 0.1 0.35 10.9 0.1 1.6 1 0 0 1 1 1 0 EF-hand domain Copine PF07002.16 ETN99704.1 - 5.6e-23 81.5 0.0 4.5e-12 45.9 0.0 2.1 2 0 0 2 2 2 2 Copine Med2 PF11214.8 ETN99705.1 - 0.019 15.1 0.2 0.028 14.5 0.2 1.3 1 1 0 1 1 1 0 Mediator complex subunit 2 Med6 PF04934.14 ETN99705.1 - 0.024 14.4 0.6 0.034 13.9 0.6 1.2 1 0 0 1 1 1 0 MED6 mediator sub complex component RE_CfrBI PF09516.10 ETN99705.1 - 0.11 11.9 2.9 0.12 11.7 2.9 1.1 1 0 0 1 1 1 0 CfrBI restriction endonuclease TPR_14 PF13428.6 ETN99706.1 - 8.9e-08 32.3 0.1 0.2 12.6 0.0 3.9 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99706.1 - 9.1e-07 28.5 0.7 0.17 12.1 0.0 4.5 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99706.1 - 2.4e-06 27.5 5.5 0.034 14.5 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETN99706.1 - 3.8e-06 27.3 0.0 0.16 12.5 0.0 3.0 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99706.1 - 1.8e-05 24.3 0.9 0.0047 16.7 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99706.1 - 3.1e-05 23.6 0.3 0.027 14.2 0.1 3.3 2 1 1 3 3 3 1 TPR repeat TPR_9 PF13371.6 ETN99706.1 - 0.00012 22.1 0.1 0.0016 18.6 0.5 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN99706.1 - 0.00013 21.9 1.7 0.0066 16.5 0.0 3.0 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 ETN99706.1 - 0.0059 16.6 0.3 4.3 7.6 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ETN99706.1 - 0.01 15.5 0.1 0.34 10.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 ETN99706.1 - 0.014 16.0 1.0 3.7 8.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99706.1 - 0.021 15.5 0.0 2.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SPESP1 PF15754.5 ETN99706.1 - 0.06 12.5 0.3 0.085 12.0 0.3 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 TPR_12 PF13424.6 ETN99706.1 - 0.11 12.8 3.0 1.7 9.0 1.9 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99706.1 - 0.27 11.5 5.9 0.78 10.0 0.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ETN99710.1 - 7e-06 25.6 0.6 7e-06 25.6 0.6 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99710.1 - 1.5e-05 24.7 0.9 4.1e-05 23.4 0.4 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETN99710.1 - 0.0018 18.5 0.3 0.0063 16.8 0.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99710.1 - 0.029 14.1 0.7 0.083 12.6 0.7 1.7 1 0 0 1 1 1 0 TPR repeat TPR_7 PF13176.6 ETN99710.1 - 0.031 14.3 0.6 0.33 11.1 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF928 PF06051.12 ETN99710.1 - 0.038 13.9 0.1 0.066 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) TPR_10 PF13374.6 ETN99710.1 - 0.042 13.7 0.9 0.1 12.5 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN99710.1 - 0.061 13.4 1.2 0.1 12.7 0.2 1.9 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETN99710.1 - 0.13 12.8 0.2 0.26 11.8 0.2 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Gluconate_2-dh3 PF13618.6 ETN99711.1 - 0.067 13.4 0.2 0.079 13.2 0.2 1.3 1 0 0 1 1 1 0 Gluconate 2-dehydrogenase subunit 3 DUF2072 PF09845.9 ETN99711.1 - 0.07 13.4 0.8 0.091 13.0 0.8 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein PABP PF00658.18 ETN99712.1 - 1.5e-22 79.5 2.5 3.6e-22 78.3 2.5 1.7 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-TRAF PF02176.18 ETN99712.1 - 0.00018 22.1 2.5 0.00092 19.9 2.5 2.1 1 1 1 2 2 2 1 TRAF-type zinc finger PDEase_I PF00233.19 ETN99713.1 - 4.6e-48 164.0 17.2 6.4e-48 163.5 5.9 3.1 2 1 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase AIG1 PF04548.16 ETN99715.1 - 1.2e-05 24.8 0.0 1.7e-05 24.2 0.0 1.2 1 0 0 1 1 1 1 AIG1 family MMR_HSR1 PF01926.23 ETN99715.1 - 2.8e-05 24.2 0.0 3.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATPase PF06745.13 ETN99715.1 - 0.0057 16.0 0.0 0.012 14.9 0.0 1.5 1 1 0 1 1 1 1 KaiC RNA_helicase PF00910.22 ETN99715.1 - 0.0062 16.9 0.0 0.02 15.3 0.0 1.8 1 1 1 2 2 2 1 RNA helicase DUF1732 PF08340.11 ETN99715.1 - 0.036 14.1 0.2 0.47 10.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1732) AAA_22 PF13401.6 ETN99715.1 - 0.049 13.9 0.0 0.11 12.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain Roc PF08477.13 ETN99715.1 - 0.05 13.8 0.0 0.095 12.9 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DAP3 PF10236.9 ETN99715.1 - 0.053 12.7 0.0 0.082 12.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Sigma54_activat PF00158.26 ETN99715.1 - 0.063 13.0 0.0 0.079 12.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain ATPase_2 PF01637.18 ETN99715.1 - 0.087 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ETN99715.1 - 0.09 13.3 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter TniB PF05621.11 ETN99715.1 - 0.14 11.5 0.0 0.83 9.0 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein RsgA_GTPase PF03193.16 ETN99715.1 - 0.16 11.9 0.0 0.29 11.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Septin PF00735.18 ETN99715.1 - 0.2 10.9 0.0 0.37 10.0 0.0 1.4 1 1 0 1 1 1 0 Septin Sigma_reg_N PF13800.6 ETN99716.1 - 0.11 12.8 2.3 0.22 11.9 2.3 1.5 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF3271 PF11675.8 ETN99716.1 - 0.11 11.7 0.1 0.14 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3271) ASFV_J13L PF05568.11 ETN99716.1 - 0.21 11.3 0.6 0.2 11.4 0.6 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF3139 PF11337.8 ETN99716.1 - 0.72 10.6 4.1 0.75 10.5 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) 7TM_GPCR_Srw PF10324.9 ETN99718.1 - 0.00036 19.9 6.4 0.00046 19.6 6.4 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srw RGS PF00615.19 ETN99718.1 - 0.0033 17.7 0.1 0.089 13.1 0.1 2.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain EphA2_TM PF14575.6 ETN99718.1 - 0.1 13.5 2.2 1 10.3 0.1 2.3 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Spt20 PF12090.8 ETN99718.1 - 0.87 9.1 9.8 0.41 10.2 2.4 2.2 2 0 0 2 2 2 0 Spt20 family DDRGK PF09756.9 ETN99718.1 - 0.91 9.1 0.0 0.91 9.1 0.0 3.1 3 0 0 3 3 3 0 DDRGK domain Med3 PF11593.8 ETN99718.1 - 3.1 6.9 10.6 17 4.5 0.1 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal Kelch_6 PF13964.6 ETN99719.1 - 5.6e-06 26.4 0.2 0.00065 19.9 0.0 2.6 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETN99719.1 - 0.00023 21.1 0.0 0.0094 15.9 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99719.1 - 0.0077 15.8 0.0 0.045 13.3 0.0 2.0 2 0 0 2 2 2 1 Kelch motif 3-HAO PF06052.12 ETN99721.1 - 3.1e-44 150.2 0.3 1.4e-43 148.2 0.1 2.0 2 1 0 2 2 2 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 ETN99721.1 - 2.3e-05 24.0 0.2 0.0018 17.9 0.1 2.8 3 0 0 3 3 3 1 Cupin domain AraC_binding PF02311.19 ETN99721.1 - 0.0078 16.1 0.1 0.028 14.3 0.1 1.9 3 0 0 3 3 3 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ETN99721.1 - 0.0082 15.8 0.0 0.39 10.3 0.0 2.2 2 0 0 2 2 2 1 Cupin DUF1229 PF06797.11 ETN99722.1 - 0.61 10.3 13.0 0.76 10.0 13.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) DUF3654 PF12376.8 ETN99723.1 - 0.012 15.8 0.2 0.03 14.5 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3654) Tubulin_C PF03953.17 ETN99724.1 - 4e-06 27.0 0.0 5.6e-06 26.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF262 PF03235.14 ETN99725.1 - 1.4 9.1 12.6 1.6 8.8 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 Acetyltransf_13 PF13880.6 ETN99726.1 - 0.051 13.6 0.1 0.21 11.6 0.0 2.0 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase TPR_8 PF13181.6 ETN99727.1 - 0.094 13.0 0.3 0.21 11.9 0.3 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat WD40 PF00400.32 ETN99728.1 - 0.0018 19.1 0.4 0.0066 17.3 0.1 2.1 3 0 0 3 3 3 1 WD domain, G-beta repeat Ig_6 PF18452.1 ETN99728.1 - 0.1 12.2 1.5 0.11 12.1 0.1 1.7 2 1 0 2 2 2 0 Immunoglobulin domain TPR_12 PF13424.6 ETN99729.1 - 3e-31 107.5 0.1 2.2e-16 59.9 0.1 2.8 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99729.1 - 4.7e-30 102.6 0.0 7.4e-11 41.6 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99729.1 - 3.4e-22 77.3 9.2 7e-11 41.5 1.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99729.1 - 2.6e-21 74.0 0.0 2.2e-06 27.3 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99729.1 - 1.7e-17 62.1 6.7 3e-08 33.2 0.4 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99729.1 - 2.1e-12 46.1 5.1 1.1e-06 28.3 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99729.1 - 4.4e-08 33.0 0.2 0.0024 18.2 0.0 3.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99729.1 - 6.1e-07 30.0 0.0 0.054 14.1 0.0 2.4 2 1 1 3 3 3 2 Tetratricopeptide repeat PPR PF01535.20 ETN99729.1 - 1.3e-05 25.1 1.6 0.029 14.6 0.2 3.1 3 0 0 3 3 3 1 PPR repeat TPR_14 PF13428.6 ETN99729.1 - 3.6e-05 24.2 0.0 4.4 8.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99729.1 - 0.00066 19.9 0.3 0.73 10.1 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETN99729.1 - 0.0014 18.3 10.1 0.49 10.1 0.2 4.5 3 2 2 5 5 5 1 TPR repeat DUF4810 PF16068.5 ETN99729.1 - 0.0023 18.4 0.3 2.5 8.7 0.0 2.3 1 1 0 2 2 2 2 Domain of unknown function (DUF4810) DUF5113 PF17140.4 ETN99729.1 - 0.004 17.0 0.8 0.74 9.6 0.1 2.4 2 1 1 3 3 3 1 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETN99729.1 - 0.0043 17.6 0.0 2 9.2 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETN99729.1 - 0.0051 16.8 2.1 1.9 8.6 0.1 3.0 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETN99729.1 - 0.022 15.3 0.0 2.4 8.7 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2777 PF10949.8 ETN99729.1 - 0.03 14.0 0.1 5.1 6.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2777) KH_4 PF13083.6 ETN99729.1 - 0.042 13.7 0.0 0.086 12.7 0.0 1.6 1 1 0 1 1 1 0 KH domain TPR_MalT PF17874.1 ETN99729.1 - 0.045 13.1 0.0 0.048 13.0 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region Fis1_TPR_C PF14853.6 ETN99729.1 - 0.067 13.3 1.2 2.4 8.3 0.2 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 ETN99729.1 - 0.091 12.2 0.0 2.7 7.5 0.0 2.8 3 1 1 4 4 4 0 SHNi-TPR HTH_Bact PF18768.1 ETN99729.1 - 0.14 11.8 1.2 4.1 7.1 0.0 3.1 3 1 1 4 4 4 0 Helix-turn-helix bacterial domain TPR_3 PF07720.12 ETN99729.1 - 0.26 11.3 4.1 0.91 9.6 0.1 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat HEAT PF02985.22 ETN99730.1 - 0.0036 17.4 0.0 0.0097 16.1 0.0 1.8 1 0 0 1 1 1 1 HEAT repeat Cnd1 PF12717.7 ETN99730.1 - 0.021 14.9 0.7 0.041 13.9 0.7 1.5 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HD_6 PF18019.1 ETN99731.1 - 0.025 14.7 0.0 0.027 14.6 0.0 1.2 1 0 0 1 1 1 0 HD domain HEAT PF02985.22 ETN99732.1 - 5.8e-09 35.5 6.7 1.4 9.4 0.0 8.6 8 1 1 9 9 8 2 HEAT repeat HEAT_2 PF13646.6 ETN99732.1 - 1.1e-08 35.4 0.0 0.11 13.0 0.0 5.4 5 1 0 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ETN99732.1 - 6e-05 23.1 12.2 0.38 10.8 2.1 4.4 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETN99732.1 - 0.00075 19.9 0.0 81 3.9 0.0 6.0 6 1 1 7 7 7 0 HEAT-like repeat RTP1_C1 PF10363.9 ETN99732.1 - 0.0053 16.9 2.1 23 5.2 0.0 4.6 4 1 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2543 PF10820.8 ETN99732.1 - 0.023 14.9 5.7 0.37 11.0 0.2 4.0 3 1 1 4 4 4 0 Protein of unknown function (DUF2543) DUF3535 PF12054.8 ETN99732.1 - 0.037 13.3 0.0 9.2 5.4 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3535) DUF4279 PF14106.6 ETN99732.1 - 0.061 13.5 1.9 1.4 9.1 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4279) DinB PF05163.12 ETN99732.1 - 0.13 12.2 0.1 0.43 10.5 0.0 1.9 2 0 0 2 2 2 0 DinB family DUF2555 PF10742.9 ETN99732.1 - 0.56 10.1 3.1 15 5.5 0.0 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2555) RUN PF02759.19 ETN99732.1 - 4.4 7.2 5.6 23 4.9 0.1 4.0 4 1 1 5 5 5 0 RUN domain Cytochrom_B_C PF00032.17 ETN99733.1 - 0.00079 19.7 4.1 0.0043 17.3 4.3 1.9 1 1 0 1 1 1 1 Cytochrome b(C-terminal)/b6/petD MerC PF03203.14 ETN99733.1 - 0.078 13.4 6.4 1.4 9.4 0.8 2.1 1 1 1 2 2 2 0 MerC mercury resistance protein DUF2975 PF11188.8 ETN99733.1 - 0.22 11.4 4.8 4.7 7.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) DUF4131 PF13567.6 ETN99733.1 - 0.26 10.9 8.2 0.34 10.5 0.1 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4131) YfhO PF09586.10 ETN99733.1 - 0.33 9.1 4.6 0.42 8.8 4.6 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO 7TMR-DISM_7TM PF07695.11 ETN99733.1 - 0.68 9.8 14.0 1.8 8.4 14.0 1.5 1 1 0 1 1 1 0 7TM diverse intracellular signalling MARVEL PF01284.23 ETN99733.1 - 2.4 8.2 12.5 22 5.1 12.6 2.1 1 1 0 1 1 1 0 Membrane-associating domain SfLAP PF11139.8 ETN99733.1 - 5.8 6.3 7.7 3.3 7.1 0.8 2.6 1 1 1 3 3 3 0 Sap, sulfolipid-1-addressing protein GWT1 PF06423.12 ETN99733.1 - 6.2 6.9 6.6 0.85 9.7 0.7 2.3 1 1 1 2 2 2 0 GWT1 WD40 PF00400.32 ETN99735.1 - 5.2e-22 77.7 12.6 3.6e-07 30.8 0.0 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETN99735.1 - 4e-07 29.1 0.0 0.041 12.5 0.0 3.0 3 0 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETN99735.1 - 3e-06 27.4 0.0 0.039 14.2 0.0 2.5 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99735.1 - 0.0067 15.8 0.1 0.078 12.3 0.0 2.1 1 1 0 2 2 2 1 WD40-like domain DUF5530 PF17670.1 ETN99735.1 - 0.062 13.1 0.4 5.9 6.7 0.0 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5530) E1-E2_ATPase PF00122.20 ETN99737.1 - 3.5e-10 39.7 0.0 4e-07 29.7 0.0 2.3 2 0 0 2 2 2 2 E1-E2 ATPase SART-1 PF03343.13 ETN99737.1 - 0.31 9.5 19.2 0.29 9.6 7.9 2.1 2 0 0 2 2 2 0 SART-1 family NPR3 PF03666.13 ETN99737.1 - 0.48 9.1 15.8 0.022 13.6 1.4 3.0 3 0 0 3 3 3 0 Nitrogen Permease regulator of amino acid transport activity 3 Fib_alpha PF08702.10 ETN99738.1 - 0.02 15.1 1.6 0.029 14.5 1.6 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4435 PF14491.6 ETN99738.1 - 0.16 11.8 7.7 0.21 11.4 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4435) UPF0029 PF01205.19 ETN99739.1 - 0.17 12.2 0.4 0.62 10.4 0.1 1.9 2 0 0 2 2 2 0 Uncharacterized protein family UPF0029 RIC3 PF15361.6 ETN99740.1 - 0.013 15.9 0.1 0.02 15.3 0.1 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Abhydrolase_5 PF12695.7 ETN99740.1 - 0.1 12.3 0.2 0.15 11.9 0.2 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Connexin PF00029.19 ETN99740.1 - 0.22 11.3 0.9 0.28 10.9 0.9 1.1 1 0 0 1 1 1 0 Connexin MFMR_assoc PF16596.5 ETN99740.1 - 0.36 11.3 7.0 0.63 10.5 7.0 1.4 1 0 0 1 1 1 0 Disordered region downstream of MFMR Presenilin PF01080.17 ETN99740.1 - 2.5 6.8 4.2 2.6 6.7 4.2 1.1 1 0 0 1 1 1 0 Presenilin Thioredoxin_11 PF18078.1 ETN99741.1 - 0.077 13.1 1.5 1.8 8.7 1.0 2.6 1 1 1 2 2 2 0 Thioredoxin-like SNTX domain Peptidase_C14 PF00656.22 ETN99742.1 - 2.8e-16 60.2 0.9 5.2e-16 59.3 0.9 1.4 1 1 0 1 1 1 1 Caspase domain Med29 PF11568.8 ETN99743.1 - 0.00031 21.0 1.3 0.00041 20.6 1.3 1.2 1 0 0 1 1 1 1 Mediator complex subunit 29 DUF4175 PF13779.6 ETN99743.1 - 0.0023 16.0 3.1 0.0029 15.6 3.1 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4175) DUF4315 PF14193.6 ETN99743.1 - 0.0064 16.5 4.1 0.011 15.7 4.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4315) Pox_G9-A16 PF03003.16 ETN99743.1 - 0.034 13.9 0.1 0.077 12.7 0.0 1.7 1 1 1 2 2 2 0 Pox virus entry-fusion-complex G9/A16 WD40 PF00400.32 ETN99744.1 - 2.6e-36 123.0 7.1 2.3e-10 40.9 0.2 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99744.1 - 5.1e-16 58.7 0.0 0.00054 20.2 0.0 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99744.1 - 1.3e-08 34.5 0.1 0.002 17.5 0.0 2.6 2 1 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETN99744.1 - 7.8e-08 32.1 0.4 1.1 9.2 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETN99744.1 - 1.2e-05 24.2 0.0 0.24 10.0 0.0 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETN99744.1 - 0.00034 19.7 0.0 3.4 6.5 0.0 3.2 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETN99744.1 - 0.0028 17.7 1.8 3.7 7.7 0.1 3.0 1 1 2 3 3 3 1 Family of unknown function (DUF5570) CSN4_RPN5_eIF3a PF18420.1 ETN99744.1 - 0.0079 16.3 1.9 24 5.2 0.0 3.3 3 0 0 3 3 3 0 CSN4/RPN5/eIF3a helix turn helix domain Proteasome_A_N PF10584.9 ETN99744.1 - 0.0098 15.6 5.8 5.9 6.7 0.0 4.2 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Nucleoporin_N PF08801.11 ETN99744.1 - 0.01 14.7 1.9 1.3 7.7 0.1 2.7 1 1 2 3 3 3 1 Nup133 N terminal like TolB_N PF04052.13 ETN99744.1 - 0.02 15.1 0.0 8.5 6.6 0.0 2.9 3 0 0 3 3 3 0 TolB amino-terminal domain BBS2_Mid PF14783.6 ETN99744.1 - 0.02 14.9 0.2 8.2 6.5 0.1 3.1 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region zf-C2H2_6 PF13912.6 ETN99744.1 - 0.027 14.5 1.3 17 5.6 0.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger Frtz PF11768.8 ETN99744.1 - 0.03 12.7 0.0 4.5 5.5 0.0 2.4 1 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz HARP PF07443.13 ETN99744.1 - 0.051 13.2 0.0 2.4 7.9 0.0 2.8 3 0 0 3 3 3 0 HepA-related protein (HARP) DUF5122 PF17164.4 ETN99744.1 - 0.083 13.2 0.9 2.7 8.4 0.1 3.2 4 1 1 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller TFR_dimer PF04253.15 ETN99745.1 - 0.017 15.3 0.0 0.36 11.0 0.0 2.1 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain TNFR_16_TM PF18422.1 ETN99745.1 - 0.53 10.3 3.0 3.1 7.8 0.1 2.5 2 0 0 2 2 2 0 Tumor necrosis factor receptor member 16 trans-membrane domain DUF2833 PF11090.8 ETN99746.1 - 0.064 13.6 0.3 0.19 12.1 0.1 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2833) TFIIF_alpha PF05793.12 ETN99749.1 - 0.46 9.0 41.2 0.51 8.9 41.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4661 PF15576.6 ETN99749.1 - 2.4 8.0 12.3 2.6 7.9 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Dynactin_p62 PF05502.13 ETN99749.1 - 2.5 6.8 11.2 2.5 6.8 11.2 1.1 1 0 0 1 1 1 0 Dynactin p62 family DDHD PF02862.17 ETN99749.1 - 3.5 7.7 9.7 4.5 7.4 9.7 1.2 1 0 0 1 1 1 0 DDHD domain SLC12 PF03522.15 ETN99749.1 - 4.3 6.3 17.6 4.6 6.2 17.6 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 ETN99749.1 - 4.8 7.2 17.1 5.9 6.9 17.1 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family CDC45 PF02724.14 ETN99749.1 - 5.2 5.2 28.2 5 5.3 28.2 1.0 1 0 0 1 1 1 0 CDC45-like protein SpoIIIAH PF12685.7 ETN99749.1 - 6.2 6.6 19.9 6.9 6.4 19.9 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein DUF2151 PF10221.9 ETN99749.1 - 7.8 5.0 20.3 8.1 4.9 20.3 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Presenilin PF01080.17 ETN99749.1 - 8.4 5.0 15.6 8.1 5.1 15.6 1.0 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ETN99749.1 - 8.5 4.3 40.9 9.7 4.2 40.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi Atrophin-1 PF03154.15 ETN99749.1 - 9.8 4.3 21.9 13 3.9 21.9 1.3 1 0 0 1 1 1 0 Atrophin-1 family RVT_1 PF00078.27 ETN99750.1 - 0.021 14.4 0.1 0.029 13.9 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) aGPT-Pplase3 PF18746.1 ETN99750.1 - 0.072 12.4 0.1 0.11 11.9 0.1 1.2 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 TFIIF_alpha PF05793.12 ETN99751.1 - 0.0066 15.1 33.7 0.0079 14.8 33.7 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PNISR PF15996.5 ETN99751.1 - 0.99 9.6 25.6 1.2 9.3 25.6 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 ETN99751.1 - 1.4 7.6 17.5 1.5 7.5 17.5 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETN99751.1 - 1.9 6.7 29.3 2.3 6.4 29.3 1.1 1 0 0 1 1 1 0 CDC45-like protein CAC1F_C PF16885.5 ETN99751.1 - 2.1 7.9 14.5 2.6 7.6 14.5 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Nop14 PF04147.12 ETN99751.1 - 2.8 6.0 30.7 2.8 6.0 30.7 1.0 1 0 0 1 1 1 0 Nop14-like family SLC12 PF03522.15 ETN99751.1 - 3 6.8 17.4 3.3 6.6 17.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 ETN99751.1 - 4.6 5.8 7.1 5.2 5.6 7.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Dsh_C PF12316.8 ETN99751.1 - 5.7 7.3 12.5 8 6.8 12.5 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SAPS PF04499.15 ETN99751.1 - 5.9 5.6 17.9 7.4 5.2 17.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LAP1C PF05609.12 ETN99752.1 - 0.11 11.6 22.3 0.13 11.4 22.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WD40 PF00400.32 ETN99753.1 - 1.1e-08 35.6 0.9 1.9e-05 25.3 0.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF851 PF05867.11 ETN99753.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF851) YabA PF06156.13 ETN99754.1 - 0.77 10.4 16.8 0.065 13.9 11.1 2.0 1 1 1 2 2 2 0 Initiation control protein YabA DUF2570 PF10828.8 ETN99754.1 - 4 7.3 9.2 3.4 7.5 7.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) SpoIISA_toxin PF14171.6 ETN99755.1 - 0.038 13.7 0.4 0.049 13.3 0.4 1.2 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system RhoGEF PF00621.20 ETN99756.1 - 2.9e-22 79.8 0.0 4e-22 79.3 0.0 1.2 1 0 0 1 1 1 1 RhoGEF domain NBD94 PF16830.5 ETN99756.1 - 0.022 15.1 1.0 0.18 12.3 0.1 2.5 2 0 0 2 2 2 0 Nucleotide-Binding Domain 94 of RH Put_DNA-bind_N PF06971.13 ETN99756.1 - 0.091 12.8 0.1 0.32 11.1 0.1 2.0 2 0 0 2 2 2 0 Putative DNA-binding protein N-terminus Coatomer_b_Cpla PF14806.6 ETN99758.1 - 0.023 14.7 0.1 0.031 14.3 0.1 1.3 1 0 0 1 1 1 0 Coatomer beta subunit appendage platform GTP_EFTU_D4 PF14578.6 ETN99759.1 - 1.5e-06 28.0 0.5 2.9e-06 27.1 0.3 1.6 2 0 0 2 2 2 1 Elongation factor Tu domain 4 GTP_EFTU_D2 PF03144.25 ETN99759.1 - 2.3e-06 27.9 0.2 4.6e-06 26.9 0.2 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 ETN99759.1 - 0.0037 16.8 0.0 0.0048 16.4 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gly_rich PF12810.7 ETN99760.1 - 0.012 15.6 0.9 0.019 14.9 0.9 1.3 1 0 0 1 1 1 0 Glycine rich protein Cpn60_TCP1 PF00118.24 ETN99763.1 - 6.8e-07 28.3 0.2 2.8e-06 26.3 0.2 1.8 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family Ntox5 PF15543.6 ETN99763.1 - 0.084 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 5 Chlorosome_CsmC PF11098.8 ETN99764.1 - 0.014 15.4 0.0 0.49 10.4 0.0 2.1 2 0 0 2 2 2 0 Chlorosome envelope protein C AviRa PF11599.8 ETN99764.1 - 0.019 14.5 0.1 0.023 14.2 0.1 1.1 1 0 0 1 1 1 0 RRNA methyltransferase AviRa Sp38 PF07354.12 ETN99764.1 - 0.077 12.4 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) NACHT PF05729.12 ETN99767.1 - 0.00025 21.0 1.9 0.0012 18.8 0.4 2.5 2 1 0 2 2 2 1 NACHT domain Tfb4 PF03850.14 ETN99770.1 - 1.6 8.2 4.5 2.4 7.6 4.5 1.2 1 0 0 1 1 1 0 Transcription factor Tfb4 RR_TM4-6 PF06459.12 ETN99770.1 - 2.2 8.1 14.2 2.8 7.7 14.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TRAP_alpha PF03896.16 ETN99770.1 - 5.4 6.1 9.3 8.7 5.4 9.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit GREB1 PF15782.5 ETN99770.1 - 6 3.9 12.4 6.6 3.7 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Connexin PF00029.19 ETN99770.1 - 6.1 6.5 6.6 8.6 6.0 6.6 1.3 1 0 0 1 1 1 0 Connexin Paramyxo_ncap PF00973.19 ETN99770.1 - 8.4 5.2 14.4 8.6 5.2 12.7 1.7 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein Hid1 PF12722.7 ETN99770.1 - 9.8 4.2 14.1 11 4.1 14.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein YL1 PF05764.13 ETN99771.1 - 0.0019 18.4 18.2 0.0034 17.5 18.2 1.4 1 0 0 1 1 1 1 YL1 nuclear protein AAA_21 PF13304.6 ETN99771.1 - 0.0047 16.8 0.4 0.0057 16.5 0.4 1.3 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SeqA PF03925.13 ETN99772.1 - 0.0037 17.2 2.4 0.005 16.8 0.1 2.0 2 0 0 2 2 2 1 SeqA protein C-terminal domain Cytochrom_C550 PF14495.6 ETN99772.1 - 0.049 13.3 0.3 0.07 12.8 0.3 1.3 1 0 0 1 1 1 0 Cytochrome c-550 domain Spidroin_N PF16763.5 ETN99772.1 - 0.057 13.4 0.2 0.091 12.8 0.2 1.3 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term PH PF00169.29 ETN99773.1 - 0.0017 18.8 0.1 0.0026 18.2 0.1 1.3 1 1 0 1 1 1 1 PH domain PH_14 PF17787.1 ETN99773.1 - 0.006 16.4 0.0 0.064 13.1 0.0 2.2 1 1 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 ETN99773.1 - 0.021 14.9 0.1 0.027 14.6 0.1 1.4 1 1 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology MotB_plug PF13677.6 ETN99774.1 - 0.48 10.1 3.4 0.88 9.2 2.3 2.0 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB MPC PF03650.13 ETN99775.1 - 0.0094 16.1 0.4 0.014 15.6 0.4 1.3 1 0 0 1 1 1 1 Mitochondrial pyruvate carriers DNA_pol_phi PF04931.13 ETN99776.1 - 0.15 10.1 15.0 0.16 10.0 15.0 1.0 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETN99776.1 - 0.26 10.6 12.4 0.29 10.4 12.4 1.1 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 ETN99776.1 - 0.28 10.3 7.8 0.29 10.3 7.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MPP6 PF10175.9 ETN99776.1 - 0.32 11.5 12.4 0.38 11.3 12.4 1.1 1 0 0 1 1 1 0 M-phase phosphoprotein 6 DUF2457 PF10446.9 ETN99776.1 - 0.33 10.1 15.0 0.33 10.0 15.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 ETN99776.1 - 0.33 10.7 11.6 0.35 10.6 11.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ETN99776.1 - 0.33 10.6 9.0 0.41 10.3 9.0 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ETN99776.1 - 0.43 8.8 13.9 0.45 8.7 13.9 1.0 1 0 0 1 1 1 0 CDC45-like protein YqhG PF11079.8 ETN99776.1 - 0.73 8.7 7.9 0.89 8.5 7.9 1.1 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function Trypan_PARP PF05887.11 ETN99776.1 - 0.76 9.8 6.3 0.87 9.6 6.3 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AAA_11 PF13086.6 ETN99776.1 - 0.89 9.3 9.2 0.9 9.3 9.2 1.0 1 0 0 1 1 1 0 AAA domain RRN3 PF05327.11 ETN99776.1 - 0.98 7.9 9.3 1.1 7.8 9.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GNAT_acetyltr_2 PF13718.6 ETN99776.1 - 1.2 8.5 5.5 1.3 8.4 5.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 PBP1_TM PF14812.6 ETN99776.1 - 1.5 9.2 18.4 8.7 6.8 18.4 1.9 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 ETN99776.1 - 2.4 8.2 16.4 2.8 8.0 16.1 1.3 1 1 0 1 1 1 0 RXT2-like, N-terminal RNA_pol_3_Rpc31 PF11705.8 ETN99776.1 - 2.9 8.1 18.0 3.7 7.7 18.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Astro_capsid_p PF12226.8 ETN99776.1 - 3.1 6.9 11.9 3.6 6.6 11.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Sporozoite_P67 PF05642.11 ETN99776.1 - 3.6 5.6 9.0 3.8 5.5 9.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Connexin PF00029.19 ETN99776.1 - 7.1 6.3 6.9 8.3 6.1 6.9 1.1 1 0 0 1 1 1 0 Connexin PUB PF09409.10 ETN99777.1 - 0.042 13.8 0.7 0.21 11.5 0.7 2.1 1 1 0 1 1 1 0 PUB domain O-antigen_lig PF13425.6 ETN99778.1 - 0.0017 17.2 5.1 0.002 17.0 5.1 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein CRA PF06589.11 ETN99778.1 - 0.099 12.8 0.3 0.099 12.8 0.3 2.2 1 1 1 2 2 2 0 Circumsporozoite-related antigen (CRA) AAA_23 PF13476.6 ETN99778.1 - 0.61 10.6 12.8 0.83 10.1 12.8 1.1 1 0 0 1 1 1 0 AAA domain REV1_C PF16727.5 ETN99779.1 - 0.028 14.8 0.2 0.056 13.8 0.2 1.4 1 0 0 1 1 1 0 DNA repair protein REV1 C-terminal domain SMC_hinge PF06470.13 ETN99779.1 - 0.15 12.4 0.0 0.29 11.4 0.0 1.5 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain RSS_P20 PF11757.8 ETN99780.1 - 0.028 14.8 4.6 0.035 14.5 4.6 1.2 1 0 0 1 1 1 0 Suppressor of RNA silencing P21-like N-terminal domain Latarcin PF10279.9 ETN99780.1 - 0.36 11.3 5.3 0.48 10.9 5.3 1.3 1 1 0 1 1 1 0 Latarcin precursor Connexin PF00029.19 ETN99781.1 - 0.23 11.2 3.0 0.25 11.1 3.0 1.0 1 0 0 1 1 1 0 Connexin GHBP PF12772.7 ETN99784.1 - 0.027 14.0 3.2 0.03 13.9 3.2 1.0 1 0 0 1 1 1 0 Growth hormone receptor binding HNOBA PF07701.14 ETN99784.1 - 0.46 9.9 7.4 0.55 9.6 7.4 1.3 1 0 0 1 1 1 0 Heme NO binding associated Folate_carrier PF01770.18 ETN99784.1 - 0.69 8.6 3.9 0.79 8.4 3.9 1.1 1 0 0 1 1 1 0 Reduced folate carrier CDC45 PF02724.14 ETN99784.1 - 1.5 7.1 15.8 1.6 7.0 15.8 1.0 1 0 0 1 1 1 0 CDC45-like protein LicD PF04991.13 ETN99784.1 - 2.3 8.3 14.8 2.4 8.2 14.8 1.1 1 0 0 1 1 1 0 LicD family Presenilin PF01080.17 ETN99784.1 - 3 6.5 8.8 3.1 6.5 8.8 1.1 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ETN99784.1 - 3.9 7.8 21.6 4.3 7.6 21.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpb1_5 PF04998.17 ETN99784.1 - 6.2 6.2 8.2 6.6 6.1 8.2 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 TMPIT PF07851.13 ETN99784.1 - 6.9 5.8 14.5 7.3 5.7 14.5 1.0 1 0 0 1 1 1 0 TMPIT-like protein Connexin PF00029.19 ETN99784.1 - 7.6 6.2 10.6 9.3 5.9 10.6 1.3 1 0 0 1 1 1 0 Connexin MDM10 PF12519.8 ETN99784.1 - 7.8 5.2 12.0 8.3 5.1 12.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TPR_12 PF13424.6 ETN99785.1 - 0.00023 21.4 0.2 0.00036 20.8 0.2 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99785.1 - 0.012 15.4 2.1 0.037 13.9 2.1 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99785.1 - 0.023 14.8 1.3 0.08 13.1 1.3 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99785.1 - 0.1 12.6 0.4 0.23 11.6 0.4 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99785.1 - 0.28 11.5 4.2 0.88 10.0 3.7 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Sensor_TM1 PF13755.6 ETN99786.1 - 0.14 11.9 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain DUF1664 PF07889.12 ETN99788.1 - 0.015 15.3 0.7 0.025 14.6 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) PilM PF07419.12 ETN99788.1 - 0.066 13.4 1.5 0.11 12.6 1.0 1.6 1 1 0 1 1 1 0 PilM COG5 PF10392.9 ETN99788.1 - 0.11 12.7 4.7 0.17 12.1 4.7 1.3 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DUF1640 PF07798.11 ETN99788.1 - 1.3 9.1 9.6 1.9 8.5 9.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) CAML PF14963.6 ETN99788.1 - 2 8.5 7.0 2.4 8.2 7.0 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Phage_TAC_3 PF06896.11 ETN99789.1 - 0.064 13.8 0.9 0.23 12.1 0.0 2.5 3 0 0 3 3 3 0 Phage tail assembly chaperone proteins, TAC GPS PF01825.21 ETN99792.1 - 0.32 11.6 5.6 0.22 12.1 2.1 2.7 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif DUF4407 PF14362.6 ETN99792.1 - 0.75 9.1 3.5 1.2 8.4 2.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Ferlin_C PF16165.5 ETN99792.1 - 1.4 8.9 9.5 0.093 12.7 3.4 2.2 2 1 0 2 2 2 0 Ferlin C-terminus MpPF26 PF07666.11 ETN99792.1 - 1.6 8.9 5.3 7.3 6.7 0.1 3.4 3 0 0 3 3 3 0 M penetrans paralogue family 26 Erythro-docking PF09277.11 ETN99793.1 - 4.4 7.3 6.4 3.4 7.7 1.1 2.3 1 1 1 2 2 2 0 Erythronolide synthase, docking Reo_P9 PF06043.11 ETN99795.1 - 0.00092 18.7 2.8 0.001 18.6 2.8 1.1 1 0 0 1 1 1 1 Reovirus P9-like family DUF3112 PF11309.8 ETN99795.1 - 0.0044 16.5 2.0 0.0047 16.4 2.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3112) Vfa1 PF08432.10 ETN99795.1 - 0.02 15.2 4.7 0.023 15.0 4.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Gag_p17 PF00540.18 ETN99795.1 - 0.16 12.0 1.9 0.2 11.6 1.9 1.1 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) Siah-Interact_N PF09032.11 ETN99795.1 - 7.5 6.9 12.8 66 3.9 12.8 2.0 1 1 0 1 1 1 0 Siah interacting protein, N terminal putAbiC PF16872.5 ETN99796.1 - 0.13 13.0 2.9 1.9 9.3 0.6 2.9 3 0 0 3 3 3 0 Putative phage abortive infection protein NACHT PF05729.12 ETN99799.1 - 0.00031 20.7 0.0 0.00033 20.6 0.0 1.2 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETN99799.1 - 0.00073 19.8 0.0 0.00078 19.7 0.0 1.3 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETN99799.1 - 0.0009 19.8 0.0 0.001 19.6 0.0 1.1 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETN99799.1 - 0.0083 16.5 0.2 0.018 15.4 0.2 1.7 1 1 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 ETN99799.1 - 0.0095 16.1 0.0 0.01 16.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain PRK PF00485.18 ETN99799.1 - 0.01 15.6 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_24 PF13479.6 ETN99799.1 - 0.012 15.4 0.0 0.013 15.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain ATP_bind_2 PF03668.15 ETN99799.1 - 0.017 14.4 0.0 0.017 14.4 0.0 1.1 1 0 0 1 1 1 0 P-loop ATPase protein family ABC_tran PF00005.27 ETN99799.1 - 0.03 14.8 0.5 0.036 14.6 0.5 1.3 1 1 0 1 1 1 0 ABC transporter PduV-EutP PF10662.9 ETN99799.1 - 0.043 13.6 0.1 0.079 12.7 0.1 1.4 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 ETN99799.1 - 0.055 13.5 0.0 0.067 13.2 0.0 1.3 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETN99799.1 - 0.059 13.7 0.0 0.061 13.7 0.0 1.1 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ETN99799.1 - 0.07 13.1 0.0 0.13 12.3 0.0 1.4 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ETN99799.1 - 0.076 12.7 0.0 0.076 12.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ETN99799.1 - 0.076 12.2 0.0 0.079 12.2 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) RsgA_GTPase PF03193.16 ETN99799.1 - 0.084 12.8 0.4 0.29 11.0 0.1 1.7 1 1 1 2 2 2 0 RsgA GTPase VirE PF05272.11 ETN99799.1 - 0.085 12.6 0.1 0.093 12.4 0.1 1.4 1 1 0 1 1 1 0 Virulence-associated protein E Cytidylate_kin PF02224.18 ETN99799.1 - 0.09 12.5 0.0 0.1 12.3 0.0 1.1 1 0 0 1 1 1 0 Cytidylate kinase CPT PF07931.12 ETN99799.1 - 0.12 12.2 0.0 0.13 12.1 0.0 1.2 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.6 ETN99799.1 - 0.19 11.5 0.1 0.3 10.9 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SCF PF02404.15 ETN99800.1 - 0.012 15.0 0.8 0.013 14.9 0.8 1.1 1 0 0 1 1 1 0 Stem cell factor Not3 PF04065.15 ETN99801.1 - 4.8e-45 153.8 20.3 5.7e-45 153.5 20.3 1.0 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Syntaxin_2 PF14523.6 ETN99801.1 - 0.023 15.0 1.6 0.023 15.0 1.6 1.9 1 1 1 2 2 2 0 Syntaxin-like protein FapA PF03961.13 ETN99801.1 - 0.56 8.7 8.3 0.63 8.6 8.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 ETN99801.1 - 2.1 7.5 8.1 2.6 7.2 8.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein AFG1_ATPase PF03969.16 ETN99803.1 - 0.12 11.3 0.0 0.24 10.2 0.0 1.5 2 0 0 2 2 2 0 AFG1-like ATPase Ntox5 PF15543.6 ETN99805.1 - 0.14 12.0 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Bacterial toxin 5 G-alpha PF00503.20 ETN99806.1 - 3.3e-12 46.2 0.1 4.2e-12 45.9 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit zf-P11 PF03854.14 ETN99807.1 - 0.083 12.6 3.9 2.8 7.7 1.3 2.4 2 0 0 2 2 2 0 P-11 zinc finger zf-MIZ PF02891.20 ETN99807.1 - 0.88 9.4 7.1 0.19 11.5 2.6 2.1 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger RGS PF00615.19 ETN99808.1 - 0.00051 20.3 0.0 0.00051 20.3 0.0 1.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain WD40 PF00400.32 ETN99809.1 - 7.2e-10 39.3 8.4 0.011 16.5 0.9 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat WD40_like PF17005.5 ETN99809.1 - 1.9e-05 24.1 3.1 4.3e-05 23.0 3.1 1.6 1 1 0 1 1 1 1 WD40-like domain Vhr1 PF04001.13 ETN99809.1 - 0.0078 16.5 0.2 0.015 15.5 0.2 1.5 1 0 0 1 1 1 1 Transcription factor Vhr1 ANAPC4_WD40 PF12894.7 ETN99809.1 - 0.016 15.5 0.0 0.1 12.9 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain YL1 PF05764.13 ETN99810.1 - 0.082 13.0 10.5 0.09 12.9 10.5 1.0 1 0 0 1 1 1 0 YL1 nuclear protein DUF2457 PF10446.9 ETN99810.1 - 0.99 8.5 19.9 1 8.4 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETN99810.1 - 1.1 7.5 13.1 1.1 7.5 13.1 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 ETN99810.1 - 1.9 8.2 7.7 2 8.1 7.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Trypan_PARP PF05887.11 ETN99810.1 - 3.4 7.7 7.6 4.5 7.3 7.6 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SDA1 PF05285.12 ETN99810.1 - 6.1 6.2 15.0 6.2 6.1 15.0 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETN99810.1 - 7.8 4.6 15.1 8.1 4.5 15.1 1.0 1 0 0 1 1 1 0 Nop14-like family HCO3_cotransp PF00955.21 ETN99812.1 - 0.11 11.3 0.9 0.11 11.2 0.9 1.2 1 0 0 1 1 1 0 HCO3- transporter family AAA_5 PF07728.14 ETN99813.1 - 3.1e-28 98.5 0.0 1e-16 61.2 0.0 3.6 3 0 0 3 3 3 3 AAA domain (dynein-related subfamily) AAA_lid_7 PF17867.1 ETN99813.1 - 1.9e-15 57.0 4.1 1.1e-13 51.3 0.2 3.5 3 0 0 3 3 3 1 Midasin AAA lid domain AAA_3 PF07726.11 ETN99813.1 - 1e-14 54.5 0.0 1.9e-11 44.0 0.0 3.4 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ETN99813.1 - 1.4e-09 38.5 0.0 0.00032 21.1 0.0 3.6 4 0 0 4 4 3 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETN99813.1 - 2.5e-07 31.2 0.0 0.024 15.0 0.0 3.1 2 0 0 2 2 2 2 AAA ATPase domain AAA_22 PF13401.6 ETN99813.1 - 7.6e-07 29.5 0.1 0.061 13.6 0.0 3.5 3 1 0 3 3 3 2 AAA domain AAA_6 PF12774.7 ETN99813.1 - 4.4e-06 25.9 0.4 0.03 13.3 0.0 3.9 3 1 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 ETN99813.1 - 4.5e-06 26.3 0.1 0.16 11.5 0.0 3.2 4 0 0 4 4 4 2 P-loop containing dynein motor region Dynein_heavy PF03028.15 ETN99813.1 - 0.00011 22.3 0.6 0.0017 18.4 0.0 3.2 4 0 0 4 4 4 1 Dynein heavy chain region D6 P-loop domain AAA_18 PF13238.6 ETN99813.1 - 0.00011 22.7 0.2 0.033 14.7 0.0 3.3 4 0 0 4 4 2 1 AAA domain Rad17 PF03215.15 ETN99813.1 - 0.00041 20.3 0.0 0.051 13.5 0.0 2.5 2 0 0 2 2 2 1 Rad17 P-loop domain TsaE PF02367.17 ETN99813.1 - 0.0012 18.9 0.1 0.31 11.0 0.0 2.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETN99813.1 - 0.0024 18.4 0.5 2.5 8.6 0.0 3.2 3 0 0 3 3 3 1 ABC transporter AAA_24 PF13479.6 ETN99813.1 - 0.003 17.3 0.8 2 8.1 0.0 3.5 3 0 0 3 3 3 1 AAA domain RsgA_GTPase PF03193.16 ETN99813.1 - 0.0033 17.3 0.0 0.36 10.7 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 ETN99813.1 - 0.004 16.5 0.0 0.017 14.4 0.0 2.0 2 0 0 2 2 2 1 Zeta toxin Mg_chelatase PF01078.21 ETN99813.1 - 0.0042 16.5 0.0 5.1 6.4 0.0 3.5 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI AAA_8 PF12780.7 ETN99813.1 - 0.0047 16.3 0.0 0.31 10.3 0.0 2.8 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 IstB_IS21 PF01695.17 ETN99813.1 - 0.0053 16.5 0.2 0.084 12.6 0.0 3.0 3 0 0 3 3 2 1 IstB-like ATP binding protein AAA_28 PF13521.6 ETN99813.1 - 0.0064 16.7 2.7 0.74 10.0 0.0 3.5 3 0 0 3 3 3 1 AAA domain DUF815 PF05673.13 ETN99813.1 - 0.0071 15.5 0.0 0.47 9.6 0.0 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ETN99813.1 - 0.02 15.3 0.0 13 6.2 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 ETN99813.1 - 0.024 14.8 1.1 7.6 6.7 0.0 3.3 3 0 0 3 3 3 0 AAA domain Sigma54_activat PF00158.26 ETN99813.1 - 0.026 14.3 0.0 4.7 6.9 0.0 2.6 3 0 0 3 3 2 0 Sigma-54 interaction domain RuvB_N PF05496.12 ETN99813.1 - 0.038 13.7 0.1 1.8 8.3 0.0 3.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Roc PF08477.13 ETN99813.1 - 0.051 13.8 0.0 21 5.4 0.0 3.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NACHT PF05729.12 ETN99813.1 - 0.073 13.0 0.6 3.4 7.6 0.1 3.1 3 0 0 3 3 3 0 NACHT domain MMR_HSR1 PF01926.23 ETN99813.1 - 0.099 12.7 0.1 8.7 6.5 0.0 3.2 4 0 0 4 4 3 0 50S ribosome-binding GTPase AAA_25 PF13481.6 ETN99813.1 - 0.11 12.0 0.0 9.4 5.8 0.1 2.5 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ETN99813.1 - 0.13 11.9 0.1 6 6.4 0.0 2.9 3 0 0 3 3 3 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 ETN99813.1 - 0.18 11.6 0.0 4.2 7.2 0.0 2.6 2 0 0 2 2 2 0 P-loop containing region of AAA domain Tipalpha PF16753.5 ETN99814.1 - 0.00077 19.3 0.1 0.0011 18.9 0.1 1.1 1 0 0 1 1 1 1 TNF-alpha-Inducing protein of Helicobacter DUF3112 PF11309.8 ETN99815.1 - 0.035 13.5 0.1 0.072 12.5 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) Dynamin_N PF00350.23 ETN99816.1 - 0.13 12.4 1.2 0.95 9.5 0.0 2.1 1 1 0 2 2 2 0 Dynamin family zf-TRAF PF02176.18 ETN99817.1 - 9.2e-06 26.3 7.7 3.3e-05 24.5 7.7 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger MyTH4 PF00784.17 ETN99817.1 - 1.1 9.8 9.3 3.5 8.2 2.7 2.8 2 1 0 2 2 2 0 MyTH4 domain zf-C3HC4_2 PF13923.6 ETN99818.1 - 0.79 9.6 7.3 4 7.4 4.7 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) PA_decarbox PF05870.11 ETN99819.1 - 0.097 12.3 0.6 0.23 11.1 0.0 1.8 3 0 0 3 3 3 0 Phenolic acid decarboxylase (PAD) SLC12 PF03522.15 ETN99821.1 - 7.8e-42 143.8 2.7 1.4e-16 60.6 0.1 3.7 2 2 1 3 3 3 3 Solute carrier family 12 Sushi_2 PF09014.10 ETN99821.1 - 0.094 12.6 0.0 0.31 11.0 0.0 1.9 1 0 0 1 1 1 0 Beta-2-glycoprotein-1 fifth domain BP28CT PF08146.12 ETN99822.1 - 0.049 13.5 0.4 5.9 6.7 0.1 2.1 1 1 1 2 2 2 0 BP28CT (NUC211) domain ubiquitin PF00240.23 ETN99825.1 - 9.3e-22 76.6 2.1 5.9e-13 48.4 0.5 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETN99825.1 - 3.6e-10 39.5 1.1 4.6e-06 26.4 0.2 2.3 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETN99825.1 - 0.012 15.6 1.1 5.2 7.2 0.0 3.3 2 2 1 3 3 3 0 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ETN99825.1 - 0.059 13.8 0.2 0.63 10.5 0.1 2.6 2 1 0 2 2 2 0 Ubiquitin-like domain CGGC PF08821.11 ETN99825.1 - 0.1 12.8 0.0 0.16 12.2 0.0 1.3 1 0 0 1 1 1 0 CGGC domain FlgH PF02107.16 ETN99826.1 - 0.044 13.4 0.1 0.071 12.7 0.1 1.3 1 0 0 1 1 1 0 Flagellar L-ring protein HEAT PF02985.22 ETN99827.1 - 1.3e-10 40.6 0.0 0.18 12.2 0.0 4.6 4 0 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 ETN99827.1 - 3.1e-06 27.5 0.0 0.0002 21.7 0.0 2.5 2 1 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 ETN99827.1 - 2.5e-05 24.7 0.0 2.4 8.8 0.0 4.5 3 2 2 5 5 5 3 HEAT-like repeat Peptidase_C14 PF00656.22 ETN99827.1 - 0.1 12.5 1.5 0.15 12.0 1.5 1.4 1 1 0 1 1 1 0 Caspase domain Cnd1 PF12717.7 ETN99827.1 - 0.21 11.6 7.5 1.3 9.0 0.8 3.1 1 1 2 3 3 3 0 non-SMC mitotic condensation complex subunit 1 PPR_2 PF13041.6 ETN99828.1 - 0.00048 20.3 0.3 0.001 19.2 0.0 1.7 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ETN99828.1 - 0.025 14.8 0.2 0.067 13.5 0.0 1.8 2 0 0 2 2 2 0 PPR repeat WHEP-TRS PF00458.20 ETN99828.1 - 0.037 14.2 0.0 0.1 12.8 0.0 1.7 2 0 0 2 2 2 0 WHEP-TRS domain zf-TRAF PF02176.18 ETN99829.1 - 3.4e-05 24.5 8.5 7.5e-05 23.3 8.5 1.7 1 1 0 1 1 1 1 TRAF-type zinc finger Shugoshin_N PF07558.11 ETN99829.1 - 0.0059 16.4 1.9 0.79 9.6 0.0 2.5 2 0 0 2 2 2 2 Shugoshin N-terminal coiled-coil region DUF4047 PF13256.6 ETN99829.1 - 0.017 15.3 2.0 0.053 13.7 2.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) FapA PF03961.13 ETN99829.1 - 0.019 13.6 2.6 0.024 13.2 2.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A FliJ PF02050.16 ETN99829.1 - 0.33 11.2 8.2 0.058 13.6 4.3 1.6 2 0 0 2 2 2 0 Flagellar FliJ protein TSC22 PF01166.18 ETN99829.1 - 0.42 11.0 6.3 2.3 8.6 3.2 2.7 2 1 1 3 3 3 0 TSC-22/dip/bun family YabA PF06156.13 ETN99829.1 - 0.46 11.2 10.4 0.044 14.4 4.9 2.1 2 1 0 2 2 2 0 Initiation control protein YabA Glyco_tran_WbsX PF14307.6 ETN99830.1 - 0.046 13.2 0.4 5.4 6.4 0.0 2.2 2 0 0 2 2 2 0 Glycosyltransferase WbsX HEAT_2 PF13646.6 ETN99830.1 - 0.06 13.7 0.0 0.22 11.9 0.0 1.9 1 1 1 2 2 2 0 HEAT repeats IL7 PF01415.16 ETN99830.1 - 0.17 11.9 4.2 0.36 10.9 4.2 1.5 1 0 0 1 1 1 0 Interleukin 7/9 family Kelch_1 PF01344.25 ETN99831.1 - 1.4e-08 34.1 0.5 4.1e-06 26.3 0.4 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETN99831.1 - 6.1e-06 26.0 0.6 0.043 13.8 0.4 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETN99831.1 - 9.8e-06 25.7 0.7 0.00063 19.9 0.2 2.3 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN99831.1 - 5.3e-05 23.1 0.7 0.0009 19.2 0.2 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN99831.1 - 0.014 15.4 0.9 0.1 12.6 0.5 2.1 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETN99831.1 - 0.015 15.6 0.0 0.032 14.5 0.0 1.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Peptidase_M1_N PF17900.1 ETN99832.1 - 6.1e-10 39.6 3.3 0.0025 18.0 0.3 3.2 1 1 2 3 3 3 3 Peptidase M1 N-terminal domain TPR_12 PF13424.6 ETN99833.1 - 1.1e-40 137.8 5.9 2.6e-18 66.1 0.0 2.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99833.1 - 1.1e-28 98.3 0.1 1.1e-09 37.8 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99833.1 - 1.3e-24 84.9 15.3 3.4e-10 39.3 1.3 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99833.1 - 2.3e-21 74.1 15.5 1e-08 34.7 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99833.1 - 7.8e-20 69.3 8.9 3.7e-07 29.8 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99833.1 - 1.7e-17 62.1 0.5 4.6e-06 26.3 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.6 ETN99833.1 - 4.9e-08 32.8 1.7 5.6e-08 32.6 1.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETN99833.1 - 1.1e-07 32.0 0.6 0.53 11.0 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99833.1 - 5.9e-07 29.4 10.0 0.01 16.1 0.1 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99833.1 - 1.9e-06 28.4 0.0 0.0095 16.6 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 ETN99833.1 - 8.6e-06 25.7 15.2 0.12 12.5 0.6 3.1 2 1 1 3 3 3 3 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETN99833.1 - 9.7e-06 24.9 2.0 0.48 9.9 0.0 3.5 3 0 0 3 3 3 2 SHNi-TPR TPR_11 PF13414.6 ETN99833.1 - 1.4e-05 24.7 16.0 0.012 15.3 1.5 5.3 2 2 3 5 5 5 2 TPR repeat TPR_14 PF13428.6 ETN99833.1 - 5.4e-05 23.7 0.0 5.1 8.2 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETN99833.1 - 0.0007 19.5 6.7 0.043 13.8 0.2 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETN99833.1 - 0.0008 19.2 6.9 0.097 12.5 0.4 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) PPR PF01535.20 ETN99833.1 - 0.0011 19.1 0.4 5.6 7.4 0.0 3.3 3 0 0 3 3 3 1 PPR repeat DUF2225 PF09986.9 ETN99833.1 - 0.0014 18.4 7.3 0.0024 17.6 7.3 1.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) ANAPC3 PF12895.7 ETN99833.1 - 0.0031 17.7 3.8 0.057 13.6 0.4 2.8 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Toxin_13 PF07822.11 ETN99833.1 - 0.088 12.9 1.7 4 7.6 0.3 2.4 2 0 0 2 2 2 0 Neurotoxin B-IV-like protein TAP_C PF03943.13 ETN99833.1 - 0.2 11.3 0.5 8.3 6.1 0.0 2.8 3 0 0 3 3 3 0 TAP C-terminal domain OrfB_IS605 PF01385.19 ETN99833.1 - 0.28 11.4 2.9 0.14 12.3 0.7 1.6 2 1 0 2 2 1 0 Probable transposase NSF PF02071.20 ETN99833.1 - 0.39 11.7 7.0 87 4.6 0.1 3.7 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat WD40 PF00400.32 ETN99835.1 - 4.5e-18 65.3 0.5 2.6e-08 34.4 0.1 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETN99835.1 - 3.1e-06 26.4 0.0 0.011 14.7 0.0 2.7 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETN99835.1 - 9.8e-06 25.1 14.9 0.0001 21.9 6.5 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETN99835.1 - 2.5e-05 24.4 0.1 5.7e-05 23.2 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) ANAPC4_WD40 PF12894.7 ETN99835.1 - 6.8e-05 23.1 0.3 0.018 15.3 0.1 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide_3 PF13576.6 ETN99835.1 - 0.015 15.4 3.7 0.04 14.1 3.7 1.8 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Nup160 PF11715.8 ETN99835.1 - 0.027 13.1 1.2 3.7 6.1 0.0 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETN99835.1 - 0.086 12.1 0.2 0.25 10.6 0.1 1.9 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETN99835.1 - 0.11 12.5 0.3 17 5.5 0.0 2.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DHC PF09626.10 ETN99836.1 - 0.021 15.7 1.4 0.021 15.7 1.4 1.8 2 0 0 2 2 2 0 Dihaem cytochrome c SEO_N PF14576.6 ETN99836.1 - 0.038 13.2 4.4 0.024 13.8 2.5 1.6 1 1 0 1 1 1 0 Sieve element occlusion N-terminus AAA-ATPase_like PF09820.9 ETN99836.1 - 0.056 12.9 4.8 0.074 12.5 4.8 1.2 1 0 0 1 1 1 0 Predicted AAA-ATPase KAP_NTPase PF07693.14 ETN99836.1 - 0.13 11.4 5.8 0.097 11.9 1.2 2.3 1 1 1 2 2 2 0 KAP family P-loop domain CAF1 PF04857.20 ETN99836.1 - 0.2 10.8 3.2 0.23 10.6 3.2 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease Tugs PF17840.1 ETN99836.1 - 0.28 11.4 3.9 0.52 10.5 0.9 2.6 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain SPG4 PF17325.2 ETN99836.1 - 0.38 11.8 9.5 0.62 11.2 6.0 2.2 2 0 0 2 2 2 0 Stationary phase protein 4 Hom_end_hint PF05203.16 ETN99836.1 - 0.98 9.3 4.3 1.4 8.8 4.3 1.2 1 0 0 1 1 1 0 Hom_end-associated Hint RNase_HII PF01351.18 ETN99836.1 - 1.8 8.3 7.8 3.2 7.5 7.7 1.5 1 1 0 1 1 1 0 Ribonuclease HII Eno-Rase_FAD_bd PF07055.12 ETN99836.1 - 6.2 7.3 7.7 2.1 8.8 0.4 3.0 3 0 0 3 3 3 0 Enoyl reductase FAD binding domain eIF-4B PF06273.11 ETN99836.1 - 6.4 5.7 7.8 8.1 5.4 7.8 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B ESP PF16590.5 ETN99837.1 - 0.15 12.4 3.2 0.47 10.8 0.3 2.2 1 1 1 2 2 2 0 Exocrine gland-secreting peptide DUF1102 PF06510.11 ETN99838.1 - 0.053 13.7 0.0 0.064 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1102) Pox_Ag35 PF03286.14 ETN99841.1 - 9.8e-05 22.2 13.5 0.00013 21.9 13.5 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein DUF3245 PF11595.8 ETN99841.1 - 0.00021 21.8 9.4 0.00025 21.5 9.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3245) Astro_capsid_p PF12226.8 ETN99841.1 - 0.00022 20.5 9.6 0.00022 20.5 9.6 1.1 1 0 0 1 1 1 1 Turkey astrovirus capsid protein Sigma70_ner PF04546.13 ETN99841.1 - 0.0008 19.3 11.0 0.00083 19.3 11.0 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region CDC45 PF02724.14 ETN99841.1 - 0.0036 15.7 13.6 0.0035 15.7 13.6 1.0 1 0 0 1 1 1 1 CDC45-like protein FYDLN_acid PF09538.10 ETN99841.1 - 0.0048 17.5 18.0 0.0068 17.1 18.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) Nop14 PF04147.12 ETN99841.1 - 0.007 14.7 21.4 0.0076 14.5 21.4 1.0 1 0 0 1 1 1 1 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 ETN99841.1 - 0.0071 16.6 23.3 0.0089 16.3 23.3 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BUD22 PF09073.10 ETN99841.1 - 0.0097 15.3 20.5 0.011 15.1 20.5 1.0 1 0 0 1 1 1 1 BUD22 DDHD PF02862.17 ETN99841.1 - 0.012 15.7 0.5 0.012 15.7 0.5 1.2 1 0 0 1 1 1 0 DDHD domain DUF5523 PF17661.1 ETN99841.1 - 0.02 14.6 18.4 0.024 14.4 18.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DNA_pol_phi PF04931.13 ETN99841.1 - 0.021 13.0 33.9 0.014 13.5 32.7 1.3 2 0 0 2 2 2 0 DNA polymerase phi CPSF100_C PF13299.6 ETN99841.1 - 0.023 14.9 7.2 0.026 14.7 7.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal PPL5 PF18168.1 ETN99841.1 - 0.023 14.0 5.7 0.025 13.9 5.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CNDH2_C PF16858.5 ETN99841.1 - 0.025 14.4 9.7 0.029 14.2 9.7 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RR_TM4-6 PF06459.12 ETN99841.1 - 0.035 13.9 14.2 0.041 13.7 14.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ETN99841.1 - 0.035 13.1 4.5 0.036 13.1 4.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 ETN99841.1 - 0.038 12.8 7.0 0.038 12.8 7.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Drc1-Sld2 PF11719.8 ETN99841.1 - 0.063 12.8 15.9 0.068 12.7 15.9 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein DUF2052 PF09747.9 ETN99841.1 - 0.066 13.3 20.6 0.083 13.0 20.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) BBL5 PF07289.11 ETN99841.1 - 0.071 12.1 1.4 0.078 12.0 1.4 1.0 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein V_ATPase_I PF01496.19 ETN99841.1 - 0.076 10.9 8.5 0.086 10.8 8.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 ETN99841.1 - 0.086 13.2 15.5 0.1 12.9 15.5 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 ETN99841.1 - 0.087 13.3 8.2 0.11 13.0 8.2 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 TFIIA PF03153.13 ETN99841.1 - 0.094 12.7 16.4 0.1 12.6 16.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RICTOR_N PF14664.6 ETN99841.1 - 0.098 11.6 0.3 0.11 11.5 0.3 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term RP-C_C PF11800.8 ETN99841.1 - 0.1 12.7 4.7 0.11 12.6 4.7 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region TLP-20 PF06088.11 ETN99841.1 - 0.12 12.2 7.9 0.17 11.7 7.9 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF5427 PF10310.9 ETN99841.1 - 0.13 11.2 12.2 0.15 11.0 12.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2457 PF10446.9 ETN99841.1 - 0.13 11.4 29.8 0.15 11.2 29.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Mpp10 PF04006.12 ETN99841.1 - 0.14 10.5 24.4 0.17 10.3 24.4 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC27 PF09507.10 ETN99841.1 - 0.15 11.4 19.4 0.19 11.1 19.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Paf1 PF03985.13 ETN99841.1 - 0.15 11.0 26.6 0.17 10.8 26.6 1.0 1 0 0 1 1 1 0 Paf1 SID-1_RNA_chan PF13965.6 ETN99841.1 - 0.16 10.3 2.8 0.16 10.3 2.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Slu7 PF11708.8 ETN99841.1 - 0.2 11.4 21.1 0.25 11.1 21.1 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor Cwf_Cwc_15 PF04889.12 ETN99841.1 - 0.28 10.9 23.3 0.34 10.6 23.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NARP1 PF12569.8 ETN99841.1 - 0.28 10.0 16.1 0.32 9.9 16.1 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 VAD1-2 PF15310.6 ETN99841.1 - 0.32 10.8 6.0 0.36 10.7 6.0 1.1 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling XRN_M PF17846.1 ETN99841.1 - 0.33 9.9 6.6 0.35 9.8 6.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Presenilin PF01080.17 ETN99841.1 - 0.37 9.5 10.1 0.41 9.3 10.1 1.0 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 ETN99841.1 - 0.53 9.7 14.0 0.62 9.5 14.0 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 ETN99841.1 - 0.63 10.1 5.6 0.75 9.8 5.6 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 F-protein PF00469.20 ETN99841.1 - 0.68 9.5 10.0 0.79 9.3 10.0 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef FAM60A PF15396.6 ETN99841.1 - 0.68 9.9 7.6 0.8 9.7 7.6 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF3295 PF11702.8 ETN99841.1 - 0.81 9.0 13.1 0.92 8.8 13.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Tim54 PF11711.8 ETN99841.1 - 0.82 8.4 12.8 0.93 8.2 12.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RPN2_C PF18004.1 ETN99841.1 - 0.83 9.6 19.1 1.3 9.0 19.1 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain GNAT_acetyltr_2 PF13718.6 ETN99841.1 - 0.86 9.0 4.6 1 8.7 4.6 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 SDA1 PF05285.12 ETN99841.1 - 0.94 8.8 25.4 1.1 8.6 25.4 1.1 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 ETN99841.1 - 1.1 7.9 14.8 1.3 7.7 14.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ETN99841.1 - 1.2 8.8 9.8 1.5 8.5 9.8 1.1 1 0 0 1 1 1 0 Connexin SspB PF04386.13 ETN99841.1 - 1.2 9.0 11.9 1.5 8.7 11.9 1.2 1 0 0 1 1 1 0 Stringent starvation protein B RNA_polI_A34 PF08208.11 ETN99841.1 - 1.3 9.0 17.4 1.6 8.8 17.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Nop53 PF07767.11 ETN99841.1 - 1.4 8.3 24.1 1.6 8.0 24.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CobT PF06213.12 ETN99841.1 - 1.7 8.0 25.0 2.1 7.7 25.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AAA_11 PF13086.6 ETN99841.1 - 1.7 8.3 7.9 2 8.1 7.9 1.1 1 0 0 1 1 1 0 AAA domain TMEM119 PF15724.5 ETN99841.1 - 1.7 8.6 6.9 2.1 8.4 6.9 1.2 1 0 0 1 1 1 0 TMEM119 family Zip PF02535.22 ETN99841.1 - 1.8 7.7 8.3 2.1 7.5 8.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CSRNP_N PF16019.5 ETN99841.1 - 1.9 8.3 9.9 2.5 7.9 9.9 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF2722 PF10846.8 ETN99841.1 - 2.2 7.1 14.5 2.6 6.9 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Afi1 PF07792.12 ETN99841.1 - 2.2 8.8 15.2 2.8 8.4 15.2 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking LAP1C PF05609.12 ETN99841.1 - 2.5 7.1 12.2 3 6.8 12.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SLC12 PF03522.15 ETN99841.1 - 2.7 6.9 7.1 3 6.8 7.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF2151 PF10221.9 ETN99841.1 - 3 6.3 11.3 3.3 6.2 11.3 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator MCM_bind PF09739.9 ETN99841.1 - 3.1 6.1 9.5 3.5 6.0 9.5 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor HSP70 PF00012.20 ETN99841.1 - 3.3 5.8 12.2 3.9 5.5 12.2 1.0 1 0 0 1 1 1 0 Hsp70 protein MDM31_MDM32 PF08118.11 ETN99841.1 - 3.7 6.1 5.9 4.4 5.9 5.9 1.0 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins DUF3824 PF12868.7 ETN99841.1 - 3.7 8.2 12.5 5 7.8 12.5 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) AIF_C PF14721.6 ETN99841.1 - 3.9 7.8 9.9 5.3 7.4 9.9 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TFB6 PF17110.5 ETN99841.1 - 3.9 7.2 14.7 5.5 6.7 14.7 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RAB3GAP2_C PF14656.6 ETN99841.1 - 4.3 5.5 6.7 4.9 5.3 6.7 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus CLN3 PF02487.17 ETN99841.1 - 4.8 6.1 5.4 5.4 6.0 5.4 1.1 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 ETN99841.1 - 5.1 5.8 5.5 5.7 5.6 5.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Ureide_permease PF07168.11 ETN99841.1 - 5.4 5.7 5.0 5.9 5.5 5.0 1.1 1 0 0 1 1 1 0 Ureide permease EIIBC-GUT_N PF03612.14 ETN99841.1 - 5.7 6.6 7.8 7.2 6.3 7.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MAS20 PF02064.15 ETN99841.1 - 6 7.0 11.0 9.1 6.4 11.0 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor PPP4R2 PF09184.11 ETN99841.1 - 7.9 6.0 26.1 10 5.6 26.1 1.1 1 0 0 1 1 1 0 PPP4R2 PA26 PF04636.13 ETN99841.1 - 8.5 5.2 7.2 9.4 5.0 7.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Cellulose_synt PF03552.14 ETN99841.1 - 9.1 4.6 6.0 10 4.5 6.0 1.0 1 0 0 1 1 1 0 Cellulose synthase PTPRCAP PF15713.5 ETN99841.1 - 9.3 6.5 23.2 13 6.0 23.2 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4746 PF15928.5 ETN99841.1 - 9.4 5.6 21.4 12 5.2 21.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) MDM10 PF12519.8 ETN99841.1 - 9.7 4.9 5.8 10 4.8 5.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 U-box PF04564.15 ETN99842.1 - 4.5e-11 42.8 0.9 1.8e-10 40.9 0.0 2.4 2 1 1 3 3 3 1 U-box domain ENT PF03735.14 ETN99842.1 - 0.25 11.4 2.6 0.42 10.7 0.7 2.3 2 0 0 2 2 2 0 ENT domain Flagellin_N PF00669.20 ETN99842.1 - 0.81 9.8 3.0 18 5.4 0.2 3.1 4 0 0 4 4 4 0 Bacterial flagellin N-terminal helical region IGR PF09597.10 ETN99842.1 - 0.93 9.6 4.1 8.1 6.6 0.1 3.1 3 0 0 3 3 3 0 IGR protein motif DUF1258 PF06869.12 ETN99843.1 - 0.022 14.2 0.4 0.034 13.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1258) DUF3450 PF11932.8 ETN99843.1 - 0.025 13.9 9.4 0.067 12.5 9.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Fez1 PF06818.15 ETN99843.1 - 0.033 14.7 17.4 0.048 14.1 17.4 1.2 1 0 0 1 1 1 0 Fez1 PV-1 PF06637.11 ETN99843.1 - 0.22 10.3 7.9 0.29 9.9 7.9 1.1 1 0 0 1 1 1 0 PV-1 protein (PLVAP) DUF87 PF01935.17 ETN99843.1 - 1.1 9.3 4.9 1.8 8.6 4.9 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain TMPIT PF07851.13 ETN99843.1 - 3.4 6.8 5.7 5.1 6.2 5.7 1.3 1 0 0 1 1 1 0 TMPIT-like protein MAGE_N PF12440.8 ETN99843.1 - 7.8 7.3 9.1 0.13 13.0 1.3 2.0 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Mucin PF01456.17 ETN99843.1 - 7.9 6.5 26.3 13 5.8 26.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein ABC_tran PF00005.27 ETN99846.1 - 2.6e-05 24.7 0.0 0.00018 22.0 0.0 2.2 3 0 0 3 3 3 1 ABC transporter AAA_5 PF07728.14 ETN99846.1 - 4.1e-05 23.6 0.0 8.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETN99846.1 - 0.00033 21.1 0.1 0.0018 18.7 0.0 2.3 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ETN99846.1 - 0.00096 19.1 1.2 0.083 12.8 0.1 2.9 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 ETN99846.1 - 0.0029 17.6 0.0 0.0052 16.7 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ETN99846.1 - 0.0034 17.8 0.0 0.0066 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_7 PF12775.7 ETN99846.1 - 0.0044 16.5 0.1 0.0097 15.4 0.1 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 ETN99846.1 - 0.0048 17.2 0.0 0.016 15.5 0.0 1.9 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ETN99846.1 - 0.0088 16.0 0.2 0.14 12.0 0.2 2.6 1 1 0 1 1 1 1 NACHT domain DUF3215 PF11503.8 ETN99846.1 - 0.013 15.3 0.1 2.4 8.0 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3215) Zeta_toxin PF06414.12 ETN99846.1 - 0.03 13.6 0.0 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 ETN99846.1 - 0.037 14.4 0.0 0.086 13.2 0.0 1.8 1 1 0 1 1 1 0 RNA helicase TsaE PF02367.17 ETN99846.1 - 0.063 13.3 0.3 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_23 PF13476.6 ETN99846.1 - 0.098 13.1 2.3 0.26 11.7 2.3 1.9 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETN99850.1 - 3.2e-08 34.2 0.0 3.8e-08 33.9 0.0 1.0 1 0 0 1 1 1 1 ABC transporter NBP1 PF08537.10 ETN99851.1 - 0.17 11.3 7.4 0.33 10.3 7.4 1.4 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 Spherulin4 PF12138.8 ETN99852.1 - 0.04 13.6 0.7 0.046 13.4 0.7 1.1 1 0 0 1 1 1 0 Spherulation-specific family 4 Cys_rich_VLP PF14194.6 ETN99852.1 - 0.11 12.6 0.6 0.22 11.7 0.3 1.8 1 1 0 1 1 1 0 Cysteine-rich VLP Thioredoxin_8 PF13905.6 ETN99852.1 - 0.14 12.5 6.6 0.14 12.5 5.4 1.5 1 1 0 1 1 1 0 Thioredoxin-like APP_N PF02177.16 ETN99857.1 - 0.079 13.3 1.1 0.1 12.9 1.1 1.3 1 0 0 1 1 1 0 Amyloid A4 N-terminal heparin-binding Kelch_1 PF01344.25 ETN99858.1 - 0.00019 21.0 0.2 0.00052 19.5 0.1 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN99858.1 - 0.00028 20.8 0.1 0.0065 16.5 0.1 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN99858.1 - 0.0016 18.3 0.1 0.15 12.1 0.1 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETN99858.1 - 0.0032 17.7 0.4 0.42 11.0 0.2 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETN99858.1 - 0.0075 16.5 0.0 0.027 14.7 0.0 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Monellin PF09200.10 ETN99858.1 - 0.028 14.3 0.1 1 9.3 0.0 3.0 3 0 0 3 3 3 0 Monellin Kelch_5 PF13854.6 ETN99858.1 - 0.036 14.1 0.0 1.8 8.6 0.1 2.4 2 0 0 2 2 2 0 Kelch motif HTH_Tnp_Tc3_2 PF01498.18 ETN99859.1 - 1.7e-13 50.6 0.1 2.8e-13 49.9 0.1 1.4 1 0 0 1 1 1 1 Transposase HTH_21 PF13276.6 ETN99859.1 - 0.00019 21.5 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 HTH-like domain HTH_32 PF13565.6 ETN99859.1 - 0.021 15.5 0.1 0.036 14.7 0.1 1.4 1 0 0 1 1 1 0 Homeodomain-like domain DUF3978 PF13123.6 ETN99859.1 - 0.086 12.6 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3978) OmdA PF13376.6 ETN99859.1 - 0.11 12.5 0.1 3.9 7.6 0.0 2.6 2 1 1 3 3 3 0 Bacteriocin-protection, YdeI or OmpD-Associated HTH_20 PF12840.7 ETN99859.1 - 0.13 12.3 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain WD40 PF00400.32 ETN99860.1 - 3.3e-15 56.2 6.4 1.2e-08 35.5 0.9 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETN99860.1 - 7.1e-05 22.3 1.3 0.00012 21.5 1.3 1.5 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETN99860.1 - 0.00015 22.0 0.1 0.015 15.6 0.0 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99860.1 - 0.00085 18.1 1.2 0.0038 16.0 0.2 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 CHASE3 PF05227.13 ETN99861.1 - 0.41 10.6 13.0 0.99 9.3 12.7 1.8 2 1 0 2 2 2 0 CHASE3 domain Rootletin PF15035.6 ETN99861.1 - 0.58 10.1 25.6 1.1 9.2 25.6 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ATP19 PF11022.8 ETN99861.1 - 1 9.8 6.0 3.5 8.1 0.1 2.5 2 0 0 2 2 2 0 ATP synthase subunit K LMBR1 PF04791.16 ETN99861.1 - 1.1 8.0 14.1 1.4 7.7 14.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TraB PF01963.17 ETN99861.1 - 1.2 9.0 12.7 0.74 9.7 10.7 1.7 1 1 1 2 2 2 0 TraB family HCO3_cotransp PF00955.21 ETN99861.1 - 2 7.2 6.3 2.5 6.8 6.3 1.4 1 0 0 1 1 1 0 HCO3- transporter family SHP PF03579.13 ETN99861.1 - 3.1 7.8 5.9 0.26 11.3 0.7 1.9 2 0 0 2 2 2 0 Small hydrophobic protein HALZ PF02183.18 ETN99861.1 - 4.1 7.7 22.7 0.99 9.7 0.2 4.0 3 1 0 3 3 3 0 Homeobox associated leucine zipper DUF4407 PF14362.6 ETN99861.1 - 4.9 6.4 17.2 7.3 5.9 17.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec20 PF03908.13 ETN99862.1 - 0.0037 17.1 1.3 0.007 16.3 0.4 2.0 2 0 0 2 2 2 1 Sec20 YscO-like PF16789.5 ETN99862.1 - 0.012 15.7 1.1 0.02 14.9 1.1 1.4 1 0 0 1 1 1 0 YscO-like protein zf-C3HC4_3 PF13920.6 ETN99862.1 - 0.042 13.7 6.1 0.12 12.2 6.1 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETN99862.1 - 0.093 12.8 2.7 0.1 12.6 0.7 2.2 2 1 0 2 2 2 0 RING-type zinc-finger Cys_knot PF00007.22 ETN99862.1 - 0.46 10.8 10.3 0.12 12.6 6.1 2.0 2 0 0 2 2 2 0 Cystine-knot domain zf-C6H2 PF15801.5 ETN99862.1 - 0.81 10.0 0.1 0.81 10.0 0.1 3.1 2 1 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding SID-1_RNA_chan PF13965.6 ETN99863.1 - 0.048 12.1 0.1 0.053 11.9 0.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Cnd1_N PF12922.7 ETN99863.1 - 0.078 12.8 3.3 0.14 12.0 1.5 2.2 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term WD40 PF00400.32 ETN99865.1 - 0.00011 22.9 1.8 0.48 11.4 0.1 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat CCDC106 PF15794.5 ETN99868.1 - 0.4 10.4 4.7 0.74 9.5 4.7 1.7 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 106 Sulfotransfer_3 PF13469.6 ETN99869.1 - 4e-08 33.9 0.2 0.00017 22.0 0.1 2.4 2 0 0 2 2 2 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 ETN99869.1 - 6.3e-06 25.9 0.2 3.3e-05 23.5 0.0 2.3 2 0 0 2 2 2 1 Sulfotransferase domain Sulfotransfer_4 PF17784.1 ETN99869.1 - 0.08 12.8 0.0 0.21 11.4 0.0 1.9 1 0 0 1 1 1 0 Sulfotransferase domain LTD PF00932.19 ETN99872.1 - 0.00015 22.1 0.0 0.00029 21.2 0.0 1.5 1 1 0 1 1 1 1 Lamin Tail Domain Tau95_N PF17682.1 ETN99873.1 - 0.092 12.9 0.3 0.2 11.9 0.3 1.4 1 1 0 1 1 1 0 Tau95 Triple barrel domain TPR_12 PF13424.6 ETN99876.1 - 1.6e-49 166.1 29.8 1.4e-17 63.7 1.2 3.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99876.1 - 4.8e-28 95.8 36.4 2.7e-06 27.0 0.7 5.9 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99876.1 - 4.3e-26 90.0 10.5 5.7e-06 26.0 0.2 5.7 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99876.1 - 4.3e-25 85.9 10.7 0.00014 21.6 0.1 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99876.1 - 1.1e-24 84.5 28.7 7.1e-06 25.7 0.3 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99876.1 - 8.3e-19 66.2 30.7 8.3e-05 22.5 1.0 5.7 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99876.1 - 1.4e-15 56.7 30.3 2.5e-05 23.8 0.3 6.5 6 1 1 7 7 7 5 TPR repeat TPR_6 PF13174.6 ETN99876.1 - 1.8e-11 43.9 6.3 0.37 11.5 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99876.1 - 2.9e-11 43.2 0.0 2 9.4 0.0 5.8 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETN99876.1 - 1.4e-09 38.4 0.8 0.002 18.7 0.0 4.2 4 1 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 ETN99876.1 - 1.9e-09 37.4 10.4 0.00043 19.8 7.3 2.9 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.9 ETN99876.1 - 1.4e-08 34.0 0.4 0.11 12.0 0.0 5.1 5 0 0 5 5 5 2 SHNi-TPR MIT PF04212.18 ETN99876.1 - 1.6e-08 34.5 16.3 0.0094 16.0 0.6 5.0 5 0 0 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETN99876.1 - 7.8e-07 29.5 3.2 0.0014 19.1 0.4 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETN99876.1 - 1.4e-06 28.2 16.3 0.075 12.7 0.1 4.1 1 1 3 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2225) TPR_17 PF13431.6 ETN99876.1 - 2.3e-06 27.6 23.3 0.018 15.4 0.3 6.0 6 2 0 6 6 5 3 Tetratricopeptide repeat TPR_3 PF07720.12 ETN99876.1 - 3.9e-06 26.7 24.2 0.00025 21.0 5.3 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99876.1 - 1.6e-05 25.1 16.8 0.0038 17.4 2.8 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETN99876.1 - 0.00033 20.1 0.1 0.00051 19.5 0.1 1.3 1 1 0 1 1 1 1 MalT-like TPR region RPN7 PF10602.9 ETN99876.1 - 0.00045 20.0 11.3 0.18 11.5 1.5 3.3 2 1 1 3 3 3 2 26S proteasome subunit RPN7 Sel1 PF08238.12 ETN99876.1 - 0.0007 20.2 14.6 1.5 9.6 0.2 5.5 5 1 0 5 5 4 1 Sel1 repeat TPR_5 PF12688.7 ETN99876.1 - 0.0044 17.2 0.8 0.25 11.6 0.0 3.6 3 2 2 5 5 5 1 Tetratrico peptide repeat TPR_9 PF13371.6 ETN99876.1 - 0.0056 16.8 0.0 0.63 10.2 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Foie-gras_1 PF11817.8 ETN99876.1 - 0.0059 16.2 0.8 0.063 12.8 0.1 2.3 2 1 0 2 2 2 1 Foie gras liver health family 1 DUF5113 PF17140.4 ETN99876.1 - 0.052 13.3 21.3 0.12 12.2 0.3 4.5 3 2 2 5 5 5 0 Domain of unknown function (DUF5113) Rapsyn_N PF10579.9 ETN99876.1 - 0.092 12.9 2.0 17 5.6 0.2 3.8 3 1 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region NSF PF02071.20 ETN99876.1 - 0.097 13.5 15.7 4.1 8.6 0.3 6.0 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat GspL_C PF12693.7 ETN99876.1 - 0.15 11.8 0.0 15 5.4 0.0 2.8 1 1 2 3 3 3 0 GspL periplasmic domain DUF2989 PF11207.8 ETN99876.1 - 0.17 11.7 8.6 1.3 8.8 1.3 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2989) HEPN PF05168.14 ETN99876.1 - 0.28 11.3 7.5 0.13 12.4 1.7 2.6 2 1 0 2 2 2 0 HEPN domain Alpha-amylase_N PF02903.14 ETN99876.1 - 0.4 10.8 5.5 7 6.8 0.2 3.3 2 1 1 3 3 3 0 Alpha amylase, N-terminal ig-like domain Lambda_Kil PF06301.11 ETN99876.1 - 0.41 10.3 1.2 3.4 7.4 0.0 2.6 3 0 0 3 3 3 0 Bacteriophage lambda Kil protein DUF4298 PF14131.6 ETN99876.1 - 0.96 9.4 15.4 1 9.4 4.3 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4298) HTH_Bact PF18768.1 ETN99876.1 - 1.5 8.4 13.7 8.3 6.1 0.1 5.0 4 1 1 5 5 5 0 Helix-turn-helix bacterial domain DUF3802 PF12290.8 ETN99876.1 - 2.6 8.6 5.4 4.2 7.9 0.3 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF3802) RabGAP-TBC PF00566.18 ETN99877.1 - 2.6e-52 177.6 4.8 2.6e-52 177.6 4.8 3.4 3 1 0 3 3 3 1 Rab-GTPase-TBC domain MMPL PF03176.15 ETN99878.1 - 2.9e-16 59.3 7.3 9.4e-14 51.1 0.3 2.9 1 1 1 2 2 2 2 MMPL family RELT PF12606.8 ETN99878.1 - 1.9 7.6 5.0 5.8 6.0 5.0 1.8 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 Kelch_6 PF13964.6 ETN99879.1 - 0.019 15.3 0.0 4 7.9 0.0 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETN99879.1 - 0.087 12.8 0.0 6.5 6.9 0.0 2.6 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETN99880.1 - 3.4e-07 30.8 0.4 0.0004 21.1 0.0 2.7 2 2 0 2 2 2 2 WD domain, G-beta repeat Kelch_6 PF13964.6 ETN99881.1 - 5.3e-09 36.1 6.2 0.0063 16.8 0.2 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETN99881.1 - 8.3e-07 28.9 3.2 0.0018 18.2 0.1 4.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99881.1 - 2e-05 24.1 4.0 0.00019 20.9 0.4 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETN99881.1 - 4e-05 23.5 12.2 0.006 16.6 0.8 5.3 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ETN99881.1 - 0.0001 22.5 1.7 0.0027 18.0 0.0 3.9 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETN99881.1 - 0.00011 22.1 3.4 0.054 13.5 0.1 4.9 5 0 0 5 5 5 1 Kelch motif WD40 PF00400.32 ETN99882.1 - 1.2e-22 79.8 12.5 5.9e-07 30.1 0.5 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99882.1 - 1.4e-07 31.7 0.3 0.045 14.1 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99882.1 - 1.8e-06 26.9 0.8 0.0016 17.2 1.2 2.9 2 1 0 2 2 2 2 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETN99882.1 - 1.4e-05 25.6 1.5 1.4e-05 25.6 1.5 3.4 3 1 1 4 4 4 1 TRAF-type zinc finger Gp-FAR-1 PF05823.12 ETN99882.1 - 0.02 15.3 11.4 0.022 15.1 4.9 2.3 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) WD40_like PF17005.5 ETN99882.1 - 0.029 13.7 0.9 0.029 13.7 0.9 3.1 2 1 0 3 3 3 0 WD40-like domain DUF4407 PF14362.6 ETN99882.1 - 0.13 11.6 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ETN99882.1 - 0.14 11.7 1.6 0.19 11.3 1.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4510 PF14971.6 ETN99882.1 - 0.17 12.2 0.1 0.37 11.1 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4510) FapA PF03961.13 ETN99882.1 - 0.4 9.2 6.5 0.29 9.7 5.0 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A PT PF04886.12 ETN99884.1 - 1.3e-06 27.8 17.4 1.3e-06 27.8 17.4 2.9 1 1 1 2 2 1 1 PT repeat TMEM154 PF15102.6 ETN99884.1 - 0.00047 20.1 1.4 0.0015 18.5 1.3 1.9 1 1 0 1 1 1 1 TMEM154 protein family SAM_2 PF07647.17 ETN99884.1 - 0.0043 17.1 0.1 0.0086 16.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETN99884.1 - 0.0055 17.1 0.0 0.0095 16.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Syndecan PF01034.20 ETN99884.1 - 0.017 15.0 0.1 0.032 14.1 0.1 1.3 1 0 0 1 1 1 0 Syndecan domain SKG6 PF08693.10 ETN99884.1 - 0.033 13.6 0.1 0.068 12.6 0.1 1.5 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Sigma_reg_N PF13800.6 ETN99884.1 - 0.043 14.1 0.0 0.09 13.1 0.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF1180 PF06679.12 ETN99884.1 - 0.056 13.9 2.8 0.13 12.7 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Amnionless PF14828.6 ETN99884.1 - 0.073 11.9 0.0 0.099 11.4 0.0 1.2 1 0 0 1 1 1 0 Amnionless Cadherin_C_2 PF16492.5 ETN99884.1 - 0.11 13.3 0.1 0.33 11.7 0.0 1.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF4692 PF15763.5 ETN99884.1 - 1.6 9.2 0.0 1.6 9.2 0.0 2.4 2 0 0 2 2 1 0 Regulator of human erythroid cell expansion (RHEX) DUF2471 PF10616.9 ETN99887.1 - 0.084 13.4 0.0 0.11 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2471) Arch_flagellin PF01917.16 ETN99888.1 - 0.012 15.8 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 Archaebacterial flagellin AAA_22 PF13401.6 ETN99888.1 - 0.022 15.0 0.0 0.095 13.0 0.0 2.0 1 1 0 2 2 2 0 AAA domain AAA PF00004.29 ETN99888.1 - 0.033 14.6 0.0 0.051 14.0 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) WD40 PF00400.32 ETN99890.1 - 2.8e-06 27.9 1.7 6.1e-06 26.9 1.7 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat IBR PF01485.21 ETN99891.1 - 0.19 12.0 11.8 0.48 10.7 11.8 1.8 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Tubulin_C PF03953.17 ETN99892.1 - 1.1e-23 83.7 0.0 1.5e-23 83.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Spc7 PF08317.11 ETN99894.1 - 0.023 13.6 11.1 0.031 13.2 11.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HALZ PF02183.18 ETN99894.1 - 0.051 13.8 0.4 0.051 13.8 0.4 2.6 1 1 1 2 2 2 0 Homeobox associated leucine zipper DUF1387 PF07139.11 ETN99894.1 - 0.088 12.5 9.9 0.12 12.1 9.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) NCKAP5 PF15246.6 ETN99894.1 - 1.9 8.1 13.9 2.2 7.8 13.9 1.1 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein Mit_KHE1 PF10173.9 ETN99894.1 - 3.3 7.7 7.9 5.9 6.9 7.9 1.4 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF573 PF04504.14 ETN99894.1 - 6.8 7.4 9.7 0.25 12.0 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function, DUF573 Spc7 PF08317.11 ETN99895.1 - 0.00059 18.8 31.8 0.00074 18.5 31.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein IFT57 PF10498.9 ETN99895.1 - 0.014 14.3 26.3 0.018 14.0 26.3 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 MscS_porin PF12795.7 ETN99895.1 - 0.11 12.0 35.0 0.14 11.7 35.0 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain YscO PF07321.12 ETN99895.1 - 0.12 12.3 35.6 0.22 11.5 15.7 2.1 1 1 1 2 2 2 0 Type III secretion protein YscO DHR10 PF18595.1 ETN99895.1 - 0.12 12.4 45.4 0.35 10.9 25.4 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF3584 PF12128.8 ETN99895.1 - 0.34 8.4 33.9 0.4 8.1 33.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Phage_GP20 PF06810.11 ETN99895.1 - 0.37 10.6 34.8 1.2 8.9 16.8 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 YscO-like PF16789.5 ETN99895.1 - 0.44 10.6 36.9 0.78 9.8 36.8 1.5 1 1 0 1 1 1 0 YscO-like protein DUF3450 PF11932.8 ETN99895.1 - 0.85 8.9 35.1 1.4 8.1 12.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 ETN99895.1 - 0.87 10.1 42.5 0.41 11.2 16.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 ETN99895.1 - 0.97 9.2 35.5 0.21 11.4 14.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 ETN99895.1 - 1.5 6.6 25.9 1.7 6.4 25.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family THOC7 PF05615.13 ETN99895.1 - 1.9 8.8 38.8 0.088 13.1 8.2 3.0 1 1 2 3 3 3 0 Tho complex subunit 7 YjcZ PF13990.6 ETN99895.1 - 3.5 6.9 11.6 4.7 6.5 11.6 1.3 1 0 0 1 1 1 0 YjcZ-like protein DUF3523 PF12037.8 ETN99895.1 - 4 6.7 34.6 4.6 6.5 34.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Bacillus_HBL PF05791.11 ETN99895.1 - 4.1 7.2 24.9 2.5 7.9 9.0 2.0 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) OmpH PF03938.14 ETN99895.1 - 4.3 7.7 46.1 1.1 9.6 20.3 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 ETN99895.1 - 5.2 6.4 39.3 2.1 7.7 18.0 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 HHA PF05321.11 ETN99895.1 - 7.2 7.0 7.4 0.93 9.9 1.3 2.5 1 1 1 2 2 2 0 Haemolysin expression modulating protein KELK PF15796.5 ETN99895.1 - 7.7 7.1 38.7 1.4 9.4 20.9 2.4 1 1 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase ERM PF00769.19 ETN99895.1 - 8.3 6.1 44.3 24 4.6 44.3 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF3552 PF12072.8 ETN99896.1 - 0.0017 17.8 103.4 0.024 14.0 43.4 4.4 1 1 2 3 3 3 3 Domain of unknown function (DUF3552) Spc7 PF08317.11 ETN99896.1 - 1 8.2 81.9 0.014 14.3 36.4 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein NACHT PF05729.12 ETN99898.1 - 0.0099 15.8 0.4 0.093 12.6 0.1 2.5 3 0 0 3 3 3 1 NACHT domain Ribosomal_L22 PF00237.19 ETN99898.1 - 0.37 11.1 1.7 2.4 8.4 0.0 2.8 3 0 0 3 3 3 0 Ribosomal protein L22p/L17e DUF4393 PF14337.6 ETN99898.1 - 1.1 9.0 6.3 1.7 8.4 0.1 3.6 2 2 1 4 4 4 0 Domain of unknown function (DUF4393) Kelch_6 PF13964.6 ETN99899.1 - 1.2e-07 31.7 0.3 0.013 15.8 0.2 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETN99899.1 - 2.1e-06 27.4 0.4 0.00022 21.1 0.2 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETN99899.1 - 9.8e-06 25.1 1.6 4.3e-05 23.0 0.3 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETN99899.1 - 1.2e-05 25.2 0.1 0.00063 19.7 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETN99899.1 - 0.0015 18.4 0.3 0.14 12.2 0.5 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETN99899.1 - 0.056 13.8 0.1 0.61 10.4 0.0 2.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Sigma54_CBD PF04963.13 ETN99900.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain FBA_2 PF07735.17 ETN99900.1 - 1.3 9.2 8.6 0.43 10.7 1.0 2.5 2 1 1 3 3 3 0 F-box associated PD40 PF07676.12 ETN99901.1 - 3.4e-10 39.6 0.3 6.1 6.9 0.0 6.2 6 0 0 6 6 6 4 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETN99901.1 - 4.3e-08 33.7 0.6 0.41 11.6 0.0 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99901.1 - 1.1e-06 28.8 0.1 0.51 10.7 0.0 5.4 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 ETN99901.1 - 2.1e-06 27.1 1.0 0.1 11.6 0.3 3.4 1 1 2 4 4 4 3 Coatomer WD associated region eIF2A PF08662.11 ETN99901.1 - 2.8e-06 27.4 1.6 0.013 15.4 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A SGL PF08450.12 ETN99901.1 - 0.07 12.7 0.5 0.35 10.4 0.2 2.3 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DUF3882 PF07066.11 ETN99902.1 - 0.033 14.2 0.1 0.038 14.0 0.1 1.1 1 0 0 1 1 1 0 Lactococcus phage M3 protein Sec34 PF04136.15 ETN99902.1 - 0.074 12.9 6.5 0.13 12.2 6.5 1.4 1 1 0 1 1 1 0 Sec34-like family IL2 PF00715.17 ETN99902.1 - 0.11 12.4 4.2 1.1 9.1 3.3 2.1 1 1 1 2 2 2 0 Interleukin 2 MMR_HSR1_C PF08438.10 ETN99902.1 - 0.14 12.7 1.6 0.39 11.3 1.6 1.8 1 1 0 1 1 1 0 GTPase of unknown function C-terminal C2 PF00168.30 ETN99903.1 - 2.3e-06 27.9 0.2 4.6e-06 26.9 0.1 1.7 2 0 0 2 2 2 1 C2 domain Cys_rich_VLP PF14194.6 ETN99904.1 - 0.063 13.4 0.4 0.12 12.5 0.4 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP SecIII_SopE_N PF05364.14 ETN99905.1 - 0.26 11.4 3.8 0.96 9.6 0.1 3.0 3 0 0 3 3 3 0 Salmonella type III secretion SopE effector N-terminus Pelovaterin PF17859.1 ETN99906.1 - 0.097 12.9 1.6 0.21 11.9 1.6 1.5 1 0 0 1 1 1 0 Pelovaterin FtsH_ext PF06480.15 ETN99907.1 - 0.14 12.6 0.9 16 5.9 0.0 2.3 2 1 0 2 2 2 0 FtsH Extracellular WD40 PF00400.32 ETN99911.1 - 1e-71 235.1 26.2 8.1e-12 45.5 0.4 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99911.1 - 1.1e-28 99.4 2.6 3.2e-05 24.1 0.0 5.8 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETN99911.1 - 2e-13 50.4 0.1 0.0013 18.1 0.0 4.3 2 1 1 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETN99911.1 - 2.7e-09 37.2 0.0 0.0019 18.1 0.0 2.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETN99911.1 - 9.4e-09 34.7 0.1 1.9 7.4 0.0 5.7 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETN99911.1 - 7.9e-08 31.4 6.6 0.33 9.5 0.2 5.5 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETN99911.1 - 5.1e-07 29.5 4.9 0.0011 18.6 1.1 3.0 1 1 1 2 2 2 2 PQQ-like domain DUF4072 PF13284.6 ETN99911.1 - 1.8e-05 25.1 0.0 15 6.1 0.0 5.6 6 0 0 6 6 6 0 Domain of unknown function (DUF4072) PD40 PF07676.12 ETN99911.1 - 2.5e-05 24.1 4.0 9.1 6.4 0.0 5.9 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETN99911.1 - 0.00036 20.3 0.0 18 5.5 0.0 4.6 5 0 0 5 5 5 0 PQQ enzyme repeat Frtz PF11768.8 ETN99911.1 - 0.00053 18.4 0.0 1.6 7.0 0.0 4.0 2 1 3 5 5 5 2 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_3 PF13570.6 ETN99911.1 - 0.0026 18.2 0.2 15 6.2 0.0 4.9 4 1 1 5 5 5 0 PQQ-like domain Cytochrom_D1 PF02239.16 ETN99911.1 - 0.0031 16.1 1.5 1.3 7.5 0.2 2.9 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETN99911.1 - 0.0053 16.8 16.6 4.8 7.3 0.1 5.7 1 1 5 6 6 6 1 Family of unknown function (DUF5570) SAND PF01342.21 ETN99911.1 - 0.0061 16.2 0.1 1.8 8.4 0.0 2.9 2 1 1 3 3 3 1 SAND domain DUF5643 PF18705.1 ETN99911.1 - 0.017 15.1 0.1 0.11 12.5 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5643) MIR PF02815.19 ETN99911.1 - 0.025 14.4 0.0 19 5.1 0.0 3.7 3 1 1 4 4 4 0 MIR domain DUF1652 PF07865.11 ETN99911.1 - 0.028 14.2 0.0 3.3 7.6 0.0 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF1652) TolB_N PF04052.13 ETN99911.1 - 0.037 14.2 0.0 71 3.6 0.0 4.5 6 0 0 6 6 6 0 TolB amino-terminal domain PKD PF00801.20 ETN99911.1 - 0.7 9.8 8.0 36 4.3 0.2 4.6 3 1 1 4 4 4 0 PKD domain ABC_membrane_2 PF06472.15 ETN99913.1 - 2.2e-07 30.6 6.7 2.5e-07 30.4 6.7 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 Ribosomal_S17_N PF16205.5 ETN99914.1 - 0.28 11.6 1.7 0.59 10.5 0.4 2.2 2 0 0 2 2 2 0 Ribosomal_S17 N-terminal HIGH_NTase1 PF05636.11 ETN99916.1 - 0.03 13.5 0.3 0.035 13.3 0.3 1.1 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase DUF2853 PF11015.8 ETN99916.1 - 0.1 13.3 0.8 4.5 8.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2853) WD40 PF00400.32 ETN99920.1 - 6.3e-21 74.3 15.6 1.5e-05 25.6 0.1 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99920.1 - 6.9e-07 29.5 0.1 0.0093 16.2 0.0 3.7 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETN99920.1 - 0.0021 16.8 4.7 3.6 6.1 0.1 3.8 1 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETN99920.1 - 0.03 13.7 3.5 0.3 10.4 0.1 2.9 2 1 1 4 4 4 0 WD40-like domain RCC1 PF00415.18 ETN99922.1 - 1.1e-26 93.2 1.9 6.1e-09 36.4 0.0 7.5 8 1 0 8 8 8 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETN99922.1 - 0.067 13.0 21.2 0.18 11.6 0.0 5.3 6 0 0 6 6 6 0 Regulator of chromosome condensation (RCC1) repeat SOG2 PF10428.9 ETN99922.1 - 0.53 9.4 9.9 0.75 8.9 9.9 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein GDYXXLXY PF14345.6 ETN99924.1 - 0.27 11.0 2.1 0.83 9.4 2.1 1.8 1 1 0 1 1 1 0 GDYXXLXY protein Kelch_4 PF13418.6 ETN99925.1 - 2.2e-06 27.6 0.0 0.001 19.0 0.0 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETN99925.1 - 0.00018 21.7 0.5 0.073 13.4 0.0 2.8 2 1 1 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETN99925.1 - 0.033 14.2 1.3 0.44 10.6 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETN99925.1 - 0.044 14.1 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99925.1 - 0.21 11.2 3.1 0.69 9.5 0.1 3.1 3 1 0 3 3 3 0 Kelch motif FH2 PF02181.23 ETN99926.1 - 9.3e-38 130.3 3.8 1e-37 130.2 3.8 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain DUF1804 PF08822.11 ETN99926.1 - 0.0096 15.9 0.9 0.021 14.8 0.2 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF1804) DUF4097 PF13349.6 ETN99927.1 - 0.15 11.4 0.1 0.18 11.2 0.1 1.0 1 0 0 1 1 1 0 Putative adhesin AAA_7 PF12775.7 ETN99929.1 - 0.00017 21.2 0.0 0.45 10.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 ETN99929.1 - 0.0037 17.7 0.0 0.17 12.3 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETN99929.1 - 0.012 15.9 1.1 0.9 9.8 0.2 4.1 4 2 0 4 4 4 0 AAA domain AAA_5 PF07728.14 ETN99929.1 - 0.093 12.7 0.3 16 5.4 0.0 3.2 2 2 0 2 2 2 0 AAA domain (dynein-related subfamily) DED PF01335.21 ETN99929.1 - 0.14 12.5 2.8 1.6 9.1 0.0 3.9 5 0 0 5 5 5 0 Death effector domain CobA_CobO_BtuR PF02572.15 ETN99929.1 - 0.16 12.2 0.3 1.8 8.8 0.0 2.5 3 0 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP APOC4 PF15119.6 ETN99931.1 - 0.054 13.8 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 Apolipoprotein C4 MIF4G PF02854.19 ETN99932.1 - 2.3e-25 89.5 6.9 5e-25 88.4 6.9 1.6 1 0 0 1 1 1 1 MIF4G domain PAM2 PF07145.15 ETN99933.1 - 0.014 15.0 0.0 0.052 13.3 0.0 2.0 1 0 0 1 1 1 0 Ataxin-2 C-terminal region DUF1564 PF07600.11 ETN99934.1 - 0.002 17.9 1.6 0.0023 17.7 1.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1564) BEN PF10523.9 ETN99934.1 - 0.024 14.9 0.2 0.042 14.1 0.2 1.6 1 1 0 1 1 1 0 BEN domain Rit1_C PF17184.4 ETN99934.1 - 0.05 13.1 1.3 0.05 13.0 1.3 1.1 1 0 0 1 1 1 0 Rit1 N-terminal domain Pox_C7_F8A PF03287.14 ETN99934.1 - 0.07 13.1 1.9 0.076 13.0 1.9 1.1 1 0 0 1 1 1 0 Poxvirus C7/F8A protein Matrilin_ccoil PF10393.9 ETN99934.1 - 2.6 8.0 7.8 0.85 9.5 1.8 2.7 1 1 1 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin SNCAIP_SNCA_bd PF16700.5 ETN99934.1 - 7.2 6.4 10.4 5.2 6.9 3.5 2.5 1 1 2 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain RVT_1 PF00078.27 ETN99935.1 - 3.6e-08 33.2 0.0 6.8e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LVIVD PF08309.11 ETN99936.1 - 0.0036 16.6 2.5 1 8.7 0.5 2.5 2 0 0 2 2 2 2 LVIVD repeat Kelch_6 PF13964.6 ETN99936.1 - 0.011 16.0 0.0 0.02 15.2 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 ETN99936.1 - 0.089 12.8 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Kelch motif DASH_Dad1 PF08649.10 ETN99938.1 - 0.054 13.7 0.3 0.12 12.6 0.3 1.6 1 0 0 1 1 1 0 DASH complex subunit Dad1 DPM3 PF08285.11 ETN99938.1 - 0.53 10.5 3.5 6.7 7.0 0.1 3.0 3 0 0 3 3 3 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) Kelch_5 PF13854.6 ETN99939.1 - 0.21 11.6 5.3 9.1 6.4 1.0 3.4 3 1 0 3 3 3 0 Kelch motif TPR_12 PF13424.6 ETN99941.1 - 9e-14 51.5 0.6 9.6e-11 41.8 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99941.1 - 1.8e-12 46.5 6.8 2.2e-05 24.1 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99941.1 - 8e-12 44.3 5.2 0.00054 19.9 0.1 4.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99941.1 - 1.1e-08 34.6 8.4 0.001 19.1 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99941.1 - 1.1e-07 31.5 0.0 0.0067 16.3 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99941.1 - 1.1e-05 25.1 1.9 0.0081 16.1 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETN99941.1 - 0.00016 22.2 0.0 1.6 9.7 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETN99941.1 - 0.0082 16.2 3.1 0.081 13.0 1.4 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 ETN99941.1 - 0.05 14.3 1.0 16 6.4 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99941.1 - 0.57 10.7 6.3 6.3 7.4 0.9 4.0 4 1 0 4 4 4 0 Tetratricopeptide repeat Iron_permease PF04120.12 ETN99942.1 - 0.4 10.4 4.5 0.44 10.3 4.5 1.1 1 0 0 1 1 1 0 Low affinity iron permease CtIP_N PF10482.9 ETN99943.1 - 0.51 10.4 5.6 0.097 12.7 1.0 1.9 2 0 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain RNA_pol_Rpc4 PF05132.14 ETN99944.1 - 0.038 14.4 0.6 0.06 13.8 0.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETN99944.1 - 0.079 11.7 2.1 0.086 11.6 2.1 1.2 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 ETN99944.1 - 0.21 12.2 17.4 0.58 10.7 17.4 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain TPR_2 PF07719.17 ETN99944.1 - 0.25 11.6 2.7 0.43 10.8 0.2 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat ALMT PF11744.8 ETN99944.1 - 0.29 9.9 4.3 0.35 9.7 4.3 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Gti1_Pac2 PF09729.9 ETN99944.1 - 0.75 9.9 7.9 1.4 9.0 7.9 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.22 ETN99944.1 - 1.5 7.9 3.3 2 7.6 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Pox_Ag35 PF03286.14 ETN99944.1 - 1.6 8.5 8.2 2.7 7.8 8.2 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Menin PF05053.13 ETN99944.1 - 2.2 6.5 10.7 2.2 6.5 9.3 1.7 2 0 0 2 2 2 0 Menin Spore_YhcN_YlaJ PF09580.10 ETN99944.1 - 5.4 7.1 22.7 8.7 6.4 22.7 1.2 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) NST1 PF13945.6 ETN99944.1 - 9.8 6.2 22.7 17 5.5 22.7 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Peptidase_M18 PF02127.15 ETN99945.1 - 2.4e-08 33.2 0.0 4.4e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) FtsX PF02687.21 ETN99946.1 - 0.018 15.5 4.1 0.018 15.5 4.1 2.2 2 0 0 2 2 2 0 FtsX-like permease family DUF1878 PF08963.10 ETN99946.1 - 0.047 14.2 0.1 0.08 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1878) Ninjurin PF04923.12 ETN99946.1 - 0.3 11.0 2.8 0.64 10.0 0.5 2.1 2 0 0 2 2 2 0 Ninjurin 2TM PF13239.6 ETN99946.1 - 0.62 10.4 14.6 0.044 14.1 5.8 2.3 2 0 0 2 2 2 0 2TM domain SUR7 PF06687.12 ETN99946.1 - 5.4 6.6 12.4 0.33 10.5 5.4 2.0 1 1 1 2 2 2 0 SUR7/PalI family Ofd1_CTDD PF10637.9 ETN99948.1 - 0.036 13.4 0.5 0.13 11.6 0.5 1.9 1 1 0 1 1 1 0 Oxoglutarate and iron-dependent oxygenase degradation C-term IMPDH PF00478.25 ETN99950.1 - 1.2e-26 93.5 0.4 1.4e-26 93.3 0.4 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Presenilin PF01080.17 ETN99952.1 - 0.15 10.8 0.5 0.17 10.6 0.5 1.2 1 0 0 1 1 1 0 Presenilin LodA_N PF17990.1 ETN99952.1 - 0.59 10.0 5.4 0.83 9.5 5.4 1.2 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal TCL1_MTCP1 PF01840.17 ETN99953.1 - 0.032 13.9 0.4 0.051 13.2 0.3 1.4 1 1 0 1 1 1 0 TCL1/MTCP1 family RVT_3 PF13456.6 ETN99953.1 - 0.05 13.4 0.5 0.071 12.9 0.5 1.2 1 0 0 1 1 1 0 Reverse transcriptase-like TORC_N PF12884.7 ETN99954.1 - 5.4 7.9 8.7 1.1 10.1 3.9 2.3 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus CLZ PF16526.5 ETN99956.1 - 0.044 14.1 0.3 12 6.4 0.0 3.1 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4713 PF15831.5 ETN99956.1 - 0.17 12.3 0.9 0.35 11.3 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) DUF4709 PF15821.5 ETN99957.1 - 0.18 12.1 0.1 0.18 12.1 0.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4709) CAP18_C PF12153.8 ETN99959.1 - 4.9 7.1 7.7 0.41 10.6 0.9 2.5 3 0 0 3 3 3 0 LPS binding domain of CAP18 (C terminal) DUF2140 PF09911.9 ETN99962.1 - 0.048 13.2 6.0 0.16 11.5 0.7 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) zf-UBP PF02148.19 ETN99962.1 - 0.093 13.1 0.0 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein DUF3333 PF11812.8 ETN99962.1 - 0.17 12.1 2.7 3.2 7.9 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3333) Choline_sulf_C PF12411.8 ETN99963.1 - 0.17 11.7 0.1 0.51 10.2 0.1 1.7 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal DUF4598 PF15370.6 ETN99964.1 - 0.12 12.9 2.4 0.15 12.5 2.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) WD40 PF00400.32 ETN99965.1 - 6.2e-21 74.3 5.6 3.5e-08 34.0 0.1 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETN99965.1 - 5.1e-09 36.3 0.0 0.00035 20.8 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETN99965.1 - 0.00036 19.6 0.2 0.071 12.1 0.0 2.8 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein LZ3wCH PF18517.1 ETN99965.1 - 0.17 12.0 1.5 0.78 9.9 0.7 2.1 1 1 1 2 2 2 0 Leucine zipper with capping helix domain SGS PF05002.15 ETN99966.1 - 0.036 14.2 4.5 0.05 13.7 4.5 1.3 1 1 0 1 1 1 0 SGS domain SEEEED PF14797.6 ETN99966.1 - 0.038 14.1 7.7 0.047 13.9 7.7 1.1 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Zip PF02535.22 ETN99966.1 - 1.9 7.6 5.5 1.9 7.6 5.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETN99966.1 - 4 6.1 5.4 4.1 6.1 5.4 1.0 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 ETN99966.1 - 9.8 4.8 7.0 11 4.7 7.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Vif PF00559.17 ETN99968.1 - 0.019 14.6 0.3 0.044 13.5 0.0 1.6 2 0 0 2 2 2 0 Retroviral Vif (Viral infectivity) protein GPS PF01825.21 ETN99969.1 - 0.00019 21.9 1.8 0.00019 21.9 1.8 1.7 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif DUF4961 PF16328.5 ETN99969.1 - 0.046 13.0 0.2 0.071 12.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4961) Cadherin_C_2 PF16492.5 ETN99969.1 - 0.063 14.0 0.2 1.5 9.6 0.0 2.5 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal CUE PF02845.16 ETN99970.1 - 0.022 14.4 0.1 0.047 13.4 0.1 1.6 1 0 0 1 1 1 0 CUE domain DUF4972 PF16342.5 ETN99970.1 - 0.028 14.1 2.8 0.17 11.6 2.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4972) EMC3_TMCO1 PF01956.16 ETN99970.1 - 0.14 11.9 0.4 0.17 11.6 0.4 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like TPR_12 PF13424.6 ETN99971.1 - 1.1e-11 44.8 0.1 8.5e-05 22.8 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99971.1 - 2e-07 30.6 0.3 0.016 15.3 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99971.1 - 8.7e-07 28.5 1.8 0.0017 18.1 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99971.1 - 4.1e-05 23.3 0.2 0.35 11.0 0.0 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99971.1 - 0.00012 22.0 3.2 0.57 10.5 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99971.1 - 0.00041 20.1 0.0 0.012 15.5 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETN99971.1 - 0.056 13.8 0.2 36 5.1 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETN99971.1 - 0.56 10.5 3.5 3.8 7.8 2.8 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ETN99971.1 - 0.76 9.9 4.6 22 5.2 0.0 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Kelch_4 PF13418.6 ETN99972.1 - 2.3e-08 33.9 0.9 0.00013 21.9 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETN99972.1 - 7.6e-08 31.8 3.0 0.00025 20.6 0.3 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETN99972.1 - 5.2e-07 29.7 1.0 0.0099 16.1 0.2 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETN99972.1 - 9.4e-07 28.7 2.6 0.015 15.3 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETN99972.1 - 7.9e-05 22.5 2.7 0.019 14.9 0.1 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETN99972.1 - 0.025 14.9 0.2 0.83 10.0 0.1 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain RPEL PF02755.15 ETN99973.1 - 1.2e-07 31.1 31.7 0.00077 19.1 1.6 9.4 10 0 0 10 10 10 5 RPEL repeat DUF2203 PF09969.9 ETN99973.1 - 0.57 10.9 0.0 0.57 10.9 0.0 4.7 2 1 4 6 6 6 0 Uncharacterized conserved protein (DUF2203) DUF3280 PF11684.8 ETN99973.1 - 9.9 6.6 15.9 2.3 8.6 0.1 4.7 5 1 0 5 5 5 0 Protein of unknown function (DUF2380) DUF1216 PF06746.11 ETN99974.1 - 0.055 13.5 13.4 0.25 11.3 2.1 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1216) Phasin_2 PF09361.10 ETN99974.1 - 0.14 12.4 0.2 0.14 12.4 0.2 3.3 5 0 0 5 5 5 0 Phasin protein DUF1664 PF07889.12 ETN99974.1 - 1.8 8.6 18.5 0.22 11.6 1.0 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF1664) FUSC PF04632.12 ETN99974.1 - 3.5 6.0 5.7 4 5.9 4.7 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family ING PF12998.7 ETN99974.1 - 3.8 8.2 22.6 0.29 11.8 0.6 4.9 4 2 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding Atg14 PF10186.9 ETN99974.1 - 4.2 6.4 25.6 0.0076 15.4 10.2 2.9 2 1 1 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Dynein_C PF18199.1 ETN99974.1 - 4.7 6.3 9.6 0.9 8.7 4.1 2.3 2 1 0 2 2 2 0 Dynein heavy chain C-terminal domain ECM11 PF15463.6 ETN99974.1 - 5.3 7.6 16.1 0.9 10.1 4.2 4.1 3 1 1 4 4 4 0 Extracellular mutant protein 11 Pkinase PF00069.25 ETN99975.1 - 3.1e-66 223.5 7.2 3.4e-66 223.3 0.9 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETN99975.1 - 8.4e-32 110.5 0.3 8.4e-32 110.5 0.3 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Dyp_perox PF04261.12 ETN99975.1 - 0.017 14.2 0.0 0.03 13.3 0.0 1.4 1 0 0 1 1 1 0 Dyp-type peroxidase family GDI PF00996.18 ETN99976.1 - 2.8e-146 487.5 1.7 7.8e-113 377.3 0.0 2.1 1 1 1 2 2 2 2 GDP dissociation inhibitor INTS5_N PF14837.6 ETN99978.1 - 0.04 13.5 0.6 5.8 6.4 0.0 2.1 2 0 0 2 2 2 0 Integrator complex subunit 5 N-terminus TetR_C_37 PF18665.1 ETN99978.1 - 0.63 10.7 5.2 2.3 8.8 2.2 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 ETN99979.1 - 0.00018 22.2 0.6 0.00034 21.3 0.6 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat RP-C_C PF11800.8 ETN99979.1 - 0.39 10.8 4.1 0.49 10.5 4.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF2370 PF10176.9 ETN99979.1 - 1.4 8.5 3.3 2 8.0 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) NPR3 PF03666.13 ETN99979.1 - 2.5 6.8 8.9 2.6 6.8 8.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETN99979.1 - 3.4 6.3 6.1 3.4 6.3 6.1 1.1 1 0 0 1 1 1 0 Presenilin Sde2_N_Ubi PF13019.6 ETN99979.1 - 3.7 7.3 5.7 5.7 6.7 5.7 1.3 1 0 0 1 1 1 0 Silencing defective 2 N-terminal ubiquitin domain PBP1_TM PF14812.6 ETN99979.1 - 4.5 7.7 11.4 7.8 7.0 11.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Terminase_4 PF05119.12 ETN99980.1 - 0.022 15.2 1.3 0.05 14.0 1.3 1.6 1 0 0 1 1 1 0 Phage terminase, small subunit Imm74 PF15603.6 ETN99980.1 - 0.049 13.8 3.1 2.4 8.4 1.2 2.5 1 1 1 2 2 2 0 Immunity protein 74 Osmo_CC PF08946.10 ETN99980.1 - 0.072 13.3 5.0 0.2 11.9 4.8 1.9 1 1 0 1 1 1 0 Osmosensory transporter coiled coil SF3b10 PF07189.11 ETN99980.1 - 0.3 11.2 2.7 0.51 10.5 0.1 2.4 2 1 0 2 2 2 0 Splicing factor 3B subunit 10 (SF3b10) DUF745 PF05335.13 ETN99980.1 - 0.68 9.6 7.1 0.39 10.4 3.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Sec34 PF04136.15 ETN99980.1 - 1.9 8.4 11.2 0.14 12.1 3.9 2.1 1 1 1 2 2 2 0 Sec34-like family Fib_alpha PF08702.10 ETN99980.1 - 2.9 8.1 13.9 5.2 7.3 13.5 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FapA PF03961.13 ETN99980.1 - 8.1 4.9 12.9 7.4 5.1 11.8 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A U-box PF04564.15 ETN99982.1 - 7.1e-11 42.1 0.0 3.1e-10 40.1 0.0 2.2 1 1 0 1 1 1 1 U-box domain DUF3450 PF11932.8 ETN99982.1 - 0.55 9.5 7.0 0.87 8.8 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PMC2NT PF08066.12 ETN99982.1 - 0.58 10.9 3.3 2.4 8.9 0.7 2.4 1 1 1 2 2 2 0 PMC2NT (NUC016) domain EpoR_lig-bind PF09067.10 ETN99983.1 - 0.014 15.6 1.0 0.025 14.8 0.7 1.5 1 1 0 1 1 1 0 Erythropoietin receptor, ligand binding Casc1 PF12366.8 ETN99985.1 - 0.0082 15.7 3.3 0.0095 15.5 3.3 1.0 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 DUF3381 PF11861.8 ETN99985.1 - 0.12 12.2 6.0 0.14 12.0 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) DUF5388 PF17363.2 ETN99986.1 - 0.056 13.6 3.0 1.9 8.7 0.0 3.3 2 1 1 3 3 3 0 Family of unknown function (DUF5388) Dynamin_N PF00350.23 ETN99986.1 - 0.1 12.6 0.1 0.74 9.8 0.0 2.4 2 0 0 2 2 2 0 Dynamin family DUF1548 PF07579.11 ETN99986.1 - 0.19 12.1 2.9 1.4 9.2 0.0 3.0 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1548) HATPase_c_5 PF14501.6 ETN99987.1 - 0.066 13.1 0.3 0.066 13.1 0.3 2.3 2 1 0 2 2 2 0 GHKL domain Peptidase_S64 PF08192.11 ETN99987.1 - 1.1 7.7 16.5 1.3 7.4 16.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 ETN99987.1 - 6.3 3.8 12.8 7.5 3.5 12.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pox_Ag35 PF03286.14 ETN99987.1 - 6.5 6.5 18.8 4.1 7.2 17.2 1.6 1 1 0 1 1 1 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 ETN99988.1 - 5.9 5.9 30.2 8.9 5.3 30.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TPR_12 PF13424.6 ETN99989.1 - 9.3e-23 80.3 0.1 2.5e-08 34.1 0.0 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETN99989.1 - 1.3e-14 53.5 0.1 0.021 14.7 0.0 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETN99989.1 - 1.2e-12 47.1 29.3 0.001 18.8 1.0 5.8 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETN99989.1 - 3.4e-12 45.5 16.1 0.0039 17.2 0.5 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETN99989.1 - 3.8e-10 39.1 4.5 0.024 14.7 0.0 4.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETN99989.1 - 1.3e-08 34.3 27.8 0.0097 16.1 0.5 5.7 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETN99989.1 - 0.002 18.7 3.7 26 5.7 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETN99989.1 - 0.002 18.0 13.8 0.069 13.2 0.6 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETN99989.1 - 0.021 14.5 25.1 0.34 10.6 1.1 5.0 5 0 0 5 5 5 0 TPR repeat Glyco_hydro_59 PF02057.15 ETN99989.1 - 0.023 13.9 1.5 0.031 13.5 0.9 1.5 1 1 0 1 1 1 0 Glycosyl hydrolase family 59 DUF725 PF05267.12 ETN99989.1 - 0.048 13.7 0.2 4.8 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF725) ANAPC3 PF12895.7 ETN99989.1 - 0.12 12.7 7.4 0.53 10.5 1.1 3.5 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ETN99989.1 - 1.3 8.4 9.6 2.8 7.3 0.1 3.4 3 1 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETN99989.1 - 1.6 9.3 11.7 9.6 6.9 0.1 4.6 4 2 1 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 ETN99989.1 - 1.8 8.7 17.4 1.9 8.6 0.8 4.2 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain CLN3 PF02487.17 ETN99991.1 - 0.32 10.0 2.7 0.39 9.7 2.7 1.4 1 1 0 1 1 1 0 CLN3 protein Orf78 PF06024.12 ETN99991.1 - 0.53 10.6 7.1 0.2 11.9 1.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Vma12 PF11712.8 ETN99991.1 - 1.9 8.6 3.9 0.87 9.6 0.7 1.8 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Peptidase_S49_N PF08496.10 ETN99991.1 - 5.1 7.1 8.9 0.74 9.9 3.9 1.8 1 1 1 2 2 2 0 Peptidase family S49 N-terminal QCR10 PF09796.9 ETN99993.1 - 0.086 12.9 0.3 0.23 11.5 0.1 1.8 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) Peptidase_S49_N PF08496.10 ETN99993.1 - 0.87 9.6 6.3 0.47 10.5 1.7 2.6 3 0 0 3 3 3 0 Peptidase family S49 N-terminal LRR_4 PF12799.7 ETN99994.1 - 0.0038 17.6 6.9 0.041 14.3 1.5 3.3 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) PCMT PF01135.19 ETN99996.1 - 0.039 13.7 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ras PF00071.22 ETN99997.1 - 9.4e-08 31.8 0.1 1.4e-07 31.2 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETN99997.1 - 2e-07 31.2 0.1 3.8e-07 30.3 0.1 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF2207 PF09972.9 ETN99997.1 - 0.017 13.9 1.2 0.017 14.0 1.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) G-alpha PF00503.20 ETN99997.1 - 0.051 12.7 0.1 0.055 12.6 0.1 1.2 1 0 0 1 1 1 0 G-protein alpha subunit TniB PF05621.11 ETN99997.1 - 0.079 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein Dicty_REP PF05086.12 ETN99998.1 - 0.098 10.6 3.8 0.095 10.7 3.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF1282 PF06930.12 ETN99998.1 - 0.12 12.1 0.4 0.18 11.5 0.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1282) TMEM154 PF15102.6 ETN99998.1 - 0.73 9.7 5.0 0.92 9.4 5.0 1.2 1 0 0 1 1 1 0 TMEM154 protein family DUF3439 PF11921.8 ETN99998.1 - 8.4 6.4 21.8 15 5.5 21.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) GDI PF00996.18 ETN99999.1 - 1.7e-12 46.6 0.4 2.2e-12 46.2 0.4 1.2 1 0 0 1 1 1 1 GDP dissociation inhibitor Zip PF02535.22 ETN99999.1 - 0.16 11.2 1.3 0.16 11.2 1.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETN99999.1 - 0.35 9.6 4.4 0.4 9.4 4.4 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETN99999.1 - 0.49 9.1 5.9 0.57 8.9 5.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 ETN99999.1 - 2.2 6.5 10.8 2.5 6.3 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Med6 PF04934.14 ETO00002.1 - 0.0053 16.6 0.5 0.0053 16.6 0.5 1.9 2 0 0 2 2 2 1 MED6 mediator sub complex component DUF3192 PF11399.8 ETO00002.1 - 0.1 12.6 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3192) WD40 PF00400.32 ETO00004.1 - 3.8e-24 84.5 13.7 4.6e-07 30.4 1.0 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO00004.1 - 5.2e-07 28.7 3.3 0.0058 15.3 1.0 3.1 2 1 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00004.1 - 9.4e-07 29.0 1.5 0.032 14.5 0.0 3.5 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Flu_B_M2 PF04772.12 ETO00004.1 - 0.17 12.1 5.7 0.3 11.3 5.7 1.5 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) FAM76 PF16046.5 ETO00004.1 - 0.24 10.7 14.5 0.33 10.3 12.5 2.2 1 1 2 3 3 3 0 FAM76 protein Atg14 PF10186.9 ETO00004.1 - 1.8 7.6 11.2 2.3 7.2 11.2 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF678 PF05077.12 ETO00006.1 - 0.097 12.8 2.6 0.24 11.5 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF678) TPR_12 PF13424.6 ETO00008.1 - 7.5e-38 128.7 0.1 1.5e-12 47.6 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00008.1 - 4e-27 92.9 22.2 6.2e-08 32.1 0.4 5.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00008.1 - 1.6e-25 87.1 11.9 1.2e-06 28.1 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00008.1 - 6.8e-25 85.2 24.6 1e-05 25.3 0.2 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00008.1 - 9.4e-25 84.8 2.4 0.00015 21.6 0.0 5.9 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00008.1 - 8.1e-19 66.9 0.0 0.00036 20.3 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00008.1 - 1e-08 35.2 3.0 0.76 10.6 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00008.1 - 1.4e-07 31.1 18.9 0.012 15.3 0.0 6.7 6 2 2 8 8 8 2 TPR repeat SNAP PF14938.6 ETO00008.1 - 4.9e-05 22.9 5.9 0.0012 18.3 1.0 2.8 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO00008.1 - 6.4e-05 23.1 2.9 2.8 8.5 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00008.1 - 9e-05 23.0 0.0 16 6.6 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00008.1 - 0.00014 22.4 0.0 0.61 10.8 0.0 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO00008.1 - 0.00065 20.2 0.2 1.7 9.2 0.1 3.7 2 2 2 4 4 4 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO00008.1 - 0.0012 19.5 1.8 5.1 7.9 0.2 3.5 3 0 0 3 3 3 2 Sel1 repeat DDE_3 PF13358.6 ETO00008.1 - 0.0028 17.4 0.4 0.006 16.3 0.4 1.5 1 0 0 1 1 1 1 DDE superfamily endonuclease SHNi-TPR PF10516.9 ETO00008.1 - 0.0052 16.2 0.4 1.5 8.4 0.0 3.9 4 0 0 4 4 4 1 SHNi-TPR MIT PF04212.18 ETO00008.1 - 0.0071 16.4 9.6 12 6.1 0.2 5.5 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO00008.1 - 0.01 15.8 17.4 1.6 8.8 0.5 5.8 5 1 0 5 5 5 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO00008.1 - 0.018 14.8 6.8 15 5.3 0.0 4.5 4 1 1 5 5 5 0 Domain of unknown function (DUF5113) Phospholip_A2_1 PF00068.19 ETO00008.1 - 0.035 14.6 0.6 6.9 7.2 0.0 3.1 3 0 0 3 3 3 0 Phospholipase A2 PPR PF01535.20 ETO00008.1 - 0.31 11.4 10.5 26 5.3 0.1 5.8 7 0 0 7 7 5 0 PPR repeat DUF627 PF04781.12 ETO00008.1 - 0.88 9.6 4.1 6.6 6.8 0.1 3.8 3 2 1 4 4 4 0 Protein of unknown function (DUF627) Ycf70 PF17382.2 ETO00008.1 - 0.88 10.0 4.9 9.7 6.7 0.1 3.7 3 1 1 4 4 4 0 Uncharacterized Ycf70-like SPO22 PF08631.10 ETO00008.1 - 1.2 8.6 5.0 6.2 6.2 1.0 3.3 1 1 3 4 4 4 0 Meiosis protein SPO22/ZIP4 like tRNA-synt_1d PF00750.19 ETO00009.1 - 0.002 17.1 0.0 0.0024 16.9 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (R) DUF1722 PF08349.11 ETO00009.1 - 0.019 15.2 1.0 0.023 15.0 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1722) CALM_bind PF16025.5 ETO00009.1 - 0.058 13.9 1.0 0.069 13.6 1.0 1.2 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding UvrA_DNA-bind PF17755.1 ETO00009.1 - 0.2 12.0 2.7 0.53 10.7 1.5 1.9 1 1 1 2 2 2 0 UvrA DNA-binding domain She9_MDM33 PF05546.11 ETO00011.1 - 0.0021 17.9 8.2 0.0026 17.6 8.2 1.1 1 0 0 1 1 1 1 She9 / Mdm33 family GAS PF13851.6 ETO00011.1 - 0.0057 16.0 13.7 0.0089 15.4 13.6 1.3 1 1 0 1 1 1 1 Growth-arrest specific micro-tubule binding SPATA1_C PF15743.5 ETO00011.1 - 0.014 15.5 7.7 0.016 15.3 7.7 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Geminin PF07412.12 ETO00011.1 - 0.025 14.3 3.7 0.025 14.3 3.7 1.8 1 1 0 1 1 1 0 Geminin DUF641 PF04859.12 ETO00011.1 - 0.038 14.3 7.5 0.08 13.3 5.5 2.4 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF16 PF01519.16 ETO00011.1 - 0.039 14.4 12.8 0.057 13.9 12.8 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 DUF4177 PF13783.6 ETO00011.1 - 0.046 14.0 1.2 0.15 12.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4177) DUF2098 PF09871.9 ETO00011.1 - 0.066 13.6 7.6 0.082 13.3 7.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) TMPIT PF07851.13 ETO00011.1 - 0.1 11.8 10.1 0.11 11.7 10.1 1.0 1 0 0 1 1 1 0 TMPIT-like protein Bap31_Bap29_C PF18035.1 ETO00011.1 - 0.11 12.5 11.3 0.2 11.7 4.8 2.4 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF4407 PF14362.6 ETO00011.1 - 0.12 11.7 4.6 0.14 11.5 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 ETO00011.1 - 0.19 12.2 13.4 0.3 11.5 13.4 1.5 1 1 0 1 1 1 0 Fez1 PhoU PF01895.19 ETO00011.1 - 0.25 11.8 2.1 0.31 11.5 2.0 1.3 1 1 0 1 1 1 0 PhoU domain FapA PF03961.13 ETO00011.1 - 0.3 9.7 9.2 0.32 9.5 9.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 ETO00011.1 - 0.57 10.4 12.3 0.65 10.2 12.3 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family PKcGMP_CC PF16808.5 ETO00011.1 - 1.2 9.0 10.3 1.6 8.7 1.0 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HIP1_clath_bdg PF16515.5 ETO00011.1 - 1.4 9.6 11.4 1.1 9.9 5.1 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ZYG-11_interact PF05884.12 ETO00011.1 - 2.6 7.4 5.6 2.7 7.3 5.6 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 FKBP_C PF00254.28 ETO00012.1 - 2.1e-05 24.7 0.2 5.5e-05 23.4 0.2 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF305 PF03713.13 ETO00012.1 - 0.29 11.3 1.6 0.35 11.0 1.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF305) DUF1299 PF06975.11 ETO00012.1 - 7.6 6.7 12.9 0.67 10.1 7.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1299) E2F_CC-MB PF16421.5 ETO00013.1 - 0.021 15.2 1.2 0.03 14.7 1.2 1.3 1 0 0 1 1 1 0 E2F transcription factor CC-MB domain Kelch_4 PF13418.6 ETO00014.1 - 1.8e-08 34.2 0.1 4.1e-08 33.1 0.1 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO00014.1 - 3.6e-07 29.7 0.9 2.9e-06 26.8 0.0 2.7 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO00014.1 - 6.7e-07 29.4 0.3 0.00014 22.0 0.1 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO00014.1 - 3.2e-05 23.7 0.2 0.0003 20.6 0.1 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO00014.1 - 0.00011 22.4 0.0 0.0003 21.0 0.0 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00014.1 - 0.0075 16.2 0.6 0.03 14.3 0.4 2.1 3 0 0 3 3 3 1 Kelch motif Ntox23 PF15528.6 ETO00014.1 - 0.1 12.8 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Bacterial toxin 23 HSP90 PF00183.18 ETO00016.1 - 2.4e-60 204.9 10.7 1.2e-50 172.9 0.0 3.1 2 1 1 3 3 3 3 Hsp90 protein P21-Arc PF04062.14 ETO00017.1 - 1.7e-24 86.8 0.2 2e-24 86.6 0.2 1.0 1 0 0 1 1 1 1 ARP2/3 complex ARPC3 (21 kDa) subunit HEAT PF02985.22 ETO00019.1 - 0.00074 19.6 0.1 0.028 14.7 0.0 2.5 3 0 0 3 3 3 1 HEAT repeat DEP PF00610.21 ETO00021.1 - 0.0037 17.3 0.0 0.011 15.8 0.0 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) WD40 PF00400.32 ETO00022.1 - 3.8e-23 81.3 14.7 3.4e-06 27.7 0.4 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00022.1 - 3e-09 37.0 2.2 0.39 11.0 0.0 4.2 4 0 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00022.1 - 8.8e-05 21.3 4.0 3.1 6.3 0.3 3.8 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00022.1 - 0.00025 20.5 3.7 1 8.6 0.0 3.5 1 1 2 4 4 4 2 WD40-like domain DUF4979 PF16351.5 ETO00022.1 - 0.034 14.4 0.6 16 5.7 0.0 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) ATP-synt_DE_N PF02823.16 ETO00022.1 - 0.13 12.2 0.0 33 4.5 0.0 2.9 3 0 0 3 3 3 0 ATP synthase, Delta/Epsilon chain, beta-sandwich domain DUF3388 PF11868.8 ETO00023.1 - 0.039 13.3 0.0 0.064 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3388) SecA_DEAD PF07517.14 ETO00026.1 - 0.037 13.3 0.0 0.057 12.7 0.0 1.3 1 0 0 1 1 1 0 SecA DEAD-like domain UvrD-helicase PF00580.21 ETO00026.1 - 0.14 11.7 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain DUF3915 PF13054.6 ETO00029.1 - 0.062 13.3 0.7 0.062 13.3 0.7 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3915) WD40 PF00400.32 ETO00030.1 - 3.5e-17 62.4 13.3 1e-07 32.5 1.2 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00030.1 - 2e-07 31.2 0.9 0.56 10.5 0.1 3.1 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00030.1 - 0.00011 21.0 1.5 0.62 8.6 0.1 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO00030.1 - 0.014 15.5 0.4 0.16 12.0 0.2 2.2 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DDE_3 PF13358.6 ETO00031.1 - 6.6e-14 51.9 3.1 6.7e-14 51.9 2.1 1.7 1 1 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 ETO00031.1 - 2e-11 44.0 2.1 2e-11 44.0 2.1 1.8 2 0 0 2 2 2 1 Transposase FUR PF01475.19 ETO00031.1 - 0.0078 16.4 0.7 0.037 14.2 0.4 2.1 2 0 0 2 2 2 1 Ferric uptake regulator family HTH_32 PF13565.6 ETO00031.1 - 0.014 16.0 0.0 0.029 15.0 0.0 1.6 1 0 0 1 1 1 0 Homeodomain-like domain DUF676 PF05057.14 ETO00033.1 - 2.8e-11 43.4 0.1 4.5e-11 42.7 0.1 1.3 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Macoilin PF09726.9 ETO00033.1 - 5.3 5.5 10.7 5.4 5.4 10.7 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO00034.1 - 0.054 12.3 1.4 0.069 11.9 1.4 1.3 1 0 0 1 1 1 0 Presenilin ArsP_2 PF11449.8 ETO00034.1 - 0.14 11.4 1.3 0.18 11.0 1.2 1.3 1 1 0 1 1 1 0 Putative, 10TM heavy-metal exporter DUF4834 PF16118.5 ETO00034.1 - 0.57 11.2 8.0 0.23 12.4 4.4 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Kelch_4 PF13418.6 ETO00037.1 - 2.5e-07 30.6 0.1 6.7e-06 26.0 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO00037.1 - 1.2e-05 24.8 0.3 0.00019 20.9 0.2 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO00037.1 - 2.3e-05 24.5 1.3 0.0078 16.5 0.2 3.2 2 1 1 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO00037.1 - 0.0019 18.4 0.0 0.013 15.8 0.0 2.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00037.1 - 0.0045 16.9 0.5 0.88 9.6 0.5 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO00037.1 - 0.024 14.6 0.1 0.4 10.7 0.1 2.4 2 0 0 2 2 2 0 Kelch motif RAG2 PF03089.14 ETO00037.1 - 0.06 12.3 0.0 0.06 12.3 0.0 1.1 1 0 0 1 1 1 0 Recombination activating protein 2 IpaC_SipC PF09599.10 ETO00038.1 - 1.4 8.3 15.2 1.3 8.5 13.7 1.6 1 1 1 2 2 2 0 Salmonella-Shigella invasin protein C (IpaC_SipC) PNISR PF15996.5 ETO00038.1 - 1.6 9.0 14.1 2.2 8.5 14.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NTP_transf_7 PF07984.12 ETO00041.1 - 0.086 12.0 0.6 0.12 11.6 0.6 1.1 1 0 0 1 1 1 0 Nucleotidyltransferase WD40 PF00400.32 ETO00044.1 - 0.027 15.4 0.0 0.061 14.2 0.0 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat DUF2207 PF09972.9 ETO00044.1 - 0.046 12.5 1.7 0.049 12.4 1.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TipE PF16972.5 ETO00044.1 - 0.99 8.5 3.9 1.5 7.9 3.9 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE Lectin_N PF03954.14 ETO00044.1 - 1.4 8.6 5.5 24 4.7 0.0 2.1 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Matrix PF00661.21 ETO00045.1 - 0.054 12.2 0.0 0.081 11.6 0.0 1.2 1 0 0 1 1 1 0 Viral matrix protein WD40 PF00400.32 ETO00046.1 - 6.2e-13 49.0 6.3 0.00075 20.3 0.5 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO00046.1 - 2.1e-07 30.0 2.3 0.0034 16.1 1.3 2.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00046.1 - 0.0039 17.4 0.4 0.79 10.1 0.0 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4867 PF16161.5 ETO00046.1 - 0.051 13.0 0.0 0.056 12.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4867) Read-through PF16814.5 ETO00046.1 - 0.27 11.0 2.0 2 8.2 0.2 2.0 1 1 1 2 2 2 0 Read-through domain zf-TRAF PF02176.18 ETO00047.1 - 3.2e-07 30.9 2.0 3.2e-07 30.9 2.0 3.3 4 1 0 4 4 4 1 TRAF-type zinc finger DUF5341 PF17276.2 ETO00047.1 - 0.11 12.6 1.1 0.29 11.3 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5341) zf-C3HC4_3 PF13920.6 ETO00047.1 - 0.12 12.2 3.9 0.96 9.4 3.9 2.5 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO00047.1 - 6.6 6.7 12.6 1.2 9.0 4.7 3.4 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-TRAF PF02176.18 ETO00048.1 - 6.2e-05 23.6 2.4 6.2e-05 23.6 2.4 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger ChuX_HutX PF06228.13 ETO00048.1 - 0.031 14.1 0.5 0.21 11.4 0.1 2.2 2 0 0 2 2 2 0 Haem utilisation ChuX/HutX zf-C3HC4_2 PF13923.6 ETO00048.1 - 1.9 8.4 4.6 14 5.6 2.1 3.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) GTP_CH_N PF12471.8 ETO00049.1 - 1.3e-08 34.8 0.3 2.9e-06 27.2 0.2 3.4 2 1 0 2 2 2 1 GTP cyclohydrolase N terminal GTP_cyclohydro2 PF00925.20 ETO00049.1 - 9.1e-05 22.1 0.0 0.00014 21.5 0.0 1.3 1 0 0 1 1 1 1 GTP cyclohydrolase II SelK_SelG PF10961.8 ETO00049.1 - 1 10.0 3.3 1.7 9.3 0.3 2.3 2 0 0 2 2 2 0 Selenoprotein SelK_SelG FixH PF05751.11 ETO00049.1 - 3.7 7.5 6.7 1.6 8.7 1.2 2.5 2 1 1 3 3 3 0 FixH ETRAMP PF09716.10 ETO00049.1 - 5 7.3 9.3 2.8 8.1 0.2 3.2 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) ATP-synt_8 PF00895.20 ETO00049.1 - 8.7 6.9 6.6 37 4.9 2.3 2.6 2 0 0 2 2 2 0 ATP synthase protein 8 Pkinase PF00069.25 ETO00050.1 - 7.8e-18 64.8 0.2 1.2e-16 60.8 0.2 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00050.1 - 2.7e-05 23.6 0.1 0.029 13.7 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase DUF4197 PF13852.6 ETO00051.1 - 0.00058 19.6 0.2 0.0013 18.5 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4197) EcsC PF12787.7 ETO00051.1 - 0.038 13.7 2.3 0.052 13.2 2.3 1.2 1 0 0 1 1 1 0 EcsC protein family DUF5305 PF17231.2 ETO00051.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) UPF0697 PF15117.6 ETO00051.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0697 FapA PF03961.13 ETO00051.1 - 4.6 5.7 6.4 0.77 8.3 2.1 1.8 2 0 0 2 2 2 0 Flagellar Assembly Protein A HEAT PF02985.22 ETO00053.1 - 2.3e-08 33.6 0.0 0.0011 19.1 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 ETO00053.1 - 4.9e-07 30.0 0.0 0.03 14.7 0.0 3.9 4 0 0 4 4 4 2 HEAT repeats RTP1_C1 PF10363.9 ETO00053.1 - 1.3e-05 25.4 0.7 0.017 15.3 0.0 2.8 2 2 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO00053.1 - 4.7e-05 23.9 2.2 0.011 16.3 0.0 3.4 2 2 2 4 4 4 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETO00053.1 - 8.3e-05 22.7 10.5 0.2 11.7 0.2 3.8 2 2 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO00053.1 - 0.0011 19.5 0.0 0.043 14.3 0.0 3.1 3 0 0 3 3 3 1 HEAT-like repeat Adaptin_N PF01602.20 ETO00053.1 - 0.0016 17.1 4.3 0.021 13.4 0.1 2.2 1 1 1 2 2 2 1 Adaptin N terminal region ENTH PF01417.20 ETO00053.1 - 0.0027 17.8 3.3 4.2 7.4 0.0 3.4 2 1 0 2 2 2 2 ENTH domain DUF4487 PF14868.6 ETO00053.1 - 0.0057 15.5 1.8 0.25 10.1 0.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4487) CLASP_N PF12348.8 ETO00053.1 - 0.0062 16.1 0.4 0.078 12.5 0.0 2.3 2 0 0 2 2 2 1 CLASP N terminal IPK PF03770.16 ETO00053.1 - 0.0067 16.3 3.1 0.037 13.9 2.9 2.1 1 1 0 1 1 1 1 Inositol polyphosphate kinase TAF6_C PF07571.13 ETO00053.1 - 0.013 15.8 0.1 8.6 6.8 0.0 3.8 3 1 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain Spore_III_AB PF09548.10 ETO00053.1 - 0.015 15.4 5.2 0.34 11.0 0.4 2.6 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Arm-DNA-bind_2 PF12167.8 ETO00053.1 - 0.071 13.0 0.1 7.2 6.6 0.0 3.3 3 0 0 3 3 2 0 Arm DNA-binding domain HEAT_PBS PF03130.16 ETO00053.1 - 0.077 13.7 0.0 4.3 8.3 0.0 3.6 4 1 0 4 4 3 0 PBS lyase HEAT-like repeat DnaG_DnaB_bind PF08278.11 ETO00053.1 - 0.098 13.3 1.3 58 4.3 0.2 3.8 3 1 1 4 4 4 0 DNA primase DnaG DnaB-binding ArAE_1_C PF11728.8 ETO00053.1 - 0.16 12.0 5.0 0.19 11.7 2.0 2.3 2 0 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain Histidinol_dh PF00815.20 ETO00053.1 - 0.18 10.8 0.1 0.32 9.9 0.1 1.3 1 0 0 1 1 1 0 Histidinol dehydrogenase DUF1018 PF06252.12 ETO00053.1 - 0.26 12.3 2.7 33 5.5 0.0 3.5 3 1 1 4 4 3 0 Protein of unknown function (DUF1018) MIT PF04212.18 ETO00053.1 - 0.29 11.2 2.4 4.4 7.4 0.9 3.5 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain DUF3819 PF12842.7 ETO00054.1 - 0.0061 16.5 0.5 0.0068 16.4 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) WD40 PF00400.32 ETO00058.1 - 0.00085 20.1 0.4 0.0031 18.3 0.5 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Beta_helix PF13229.6 ETO00058.1 - 0.0052 16.6 1.2 0.0056 16.5 1.2 1.1 1 0 0 1 1 1 1 Right handed beta helix region UDPG_MGDP_dh PF00984.19 ETO00059.1 - 0.02 15.1 0.1 0.03 14.5 0.1 1.2 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain YppF PF14178.6 ETO00059.1 - 0.11 12.4 5.0 0.12 12.3 0.3 2.3 1 1 1 2 2 2 0 YppF-like protein HEAT PF02985.22 ETO00060.1 - 2.9e-07 30.2 0.0 0.0038 17.3 0.0 2.4 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 ETO00060.1 - 0.0039 17.5 0.0 0.29 11.6 0.0 2.1 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETO00060.1 - 0.0085 16.1 0.0 0.014 15.4 0.0 1.4 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETO00060.1 - 0.013 15.1 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 CLASP N terminal DUF3283 PF11686.8 ETO00060.1 - 0.022 14.6 0.0 0.047 13.5 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3283) HEAT_EZ PF13513.6 ETO00060.1 - 0.029 14.9 0.0 0.061 13.9 0.0 1.6 1 0 0 1 1 1 0 HEAT-like repeat FmiP_Thoc5 PF09766.9 ETO00062.1 - 0.0042 16.4 6.4 0.0042 16.4 6.4 1.8 1 1 0 2 2 2 1 Fms-interacting protein/Thoc5 GCN5L1 PF06320.13 ETO00062.1 - 0.013 15.6 5.7 0.019 15.1 5.7 1.4 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) RHSP PF07999.11 ETO00062.1 - 0.089 11.6 0.9 0.097 11.5 0.9 1.0 1 0 0 1 1 1 0 Retrotransposon hot spot protein NYD-SP28_assoc PF14775.6 ETO00062.1 - 0.12 12.4 2.7 0.16 12.1 1.5 1.9 1 1 1 2 2 2 0 Sperm tail C-terminal domain ZYG-11_interact PF05884.12 ETO00062.1 - 0.25 10.7 0.7 0.28 10.6 0.7 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 XhlA PF10779.9 ETO00062.1 - 0.45 10.8 4.3 0.22 11.8 2.1 1.7 2 0 0 2 2 2 0 Haemolysin XhlA Jnk-SapK_ap_N PF09744.9 ETO00062.1 - 4.9 7.3 15.5 16 5.7 15.3 1.8 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 RtcR PF06956.11 ETO00064.1 - 0.06 12.8 0.1 0.062 12.7 0.1 1.2 1 0 0 1 1 1 0 Regulator of RNA terminal phosphate cyclase DUF4215 PF13948.6 ETO00064.1 - 0.15 12.5 5.0 0.2 12.1 5.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) Aminotran_1_2 PF00155.21 ETO00065.1 - 4.6e-22 78.7 0.0 5.3e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Jiraiya PF15038.6 ETO00065.1 - 0.041 13.3 0.2 0.061 12.8 0.2 1.3 1 0 0 1 1 1 0 Jiraiya DUF1987 PF09345.10 ETO00067.1 - 0.051 13.3 0.9 0.07 12.8 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1987) GNAT_acetyltr_2 PF13718.6 ETO00069.1 - 0.02 14.3 2.4 0.025 14.0 2.4 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase 2 RNA_pol_Rpc4 PF05132.14 ETO00069.1 - 0.52 10.7 5.8 0.62 10.5 5.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETO00069.1 - 0.94 8.2 4.8 0.97 8.1 4.8 1.0 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.13 ETO00069.1 - 0.98 8.2 3.4 1.1 8.1 3.4 1.0 1 0 0 1 1 1 0 Otopetrin CDC45 PF02724.14 ETO00069.1 - 1.2 7.4 7.2 1.3 7.3 7.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO00069.1 - 2.3 7.9 4.0 2.6 7.7 4.0 1.0 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 ETO00069.1 - 3.6 7.5 4.4 4.1 7.3 4.4 1.0 1 0 0 1 1 1 0 N-glycosylation protein Mito_carr PF00153.27 ETO00070.1 - 1.8e-08 34.2 0.4 4.7e-05 23.2 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial carrier protein AAA_5 PF07728.14 ETO00072.1 - 1.6e-05 24.9 0.0 3.1e-05 24.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO00072.1 - 0.00011 22.6 0.0 0.00023 21.6 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ETO00072.1 - 0.00025 21.6 0.0 0.00054 20.5 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETO00072.1 - 0.00035 20.2 0.1 0.00091 18.8 0.1 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 ETO00072.1 - 0.00076 19.5 0.2 0.084 12.8 0.0 2.2 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO00072.1 - 0.0015 18.9 0.0 0.0023 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO00072.1 - 0.0031 17.5 0.0 0.0041 17.0 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase NACHT PF05729.12 ETO00072.1 - 0.0038 17.1 0.1 0.048 13.6 0.1 2.4 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO00072.1 - 0.0041 17.4 0.4 0.016 15.5 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO00072.1 - 0.028 15.0 0.1 0.068 13.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain MCM PF00493.23 ETO00072.1 - 0.033 13.3 0.0 0.33 10.0 0.0 2.2 2 0 0 2 2 2 0 MCM P-loop domain TsaE PF02367.17 ETO00072.1 - 0.038 14.0 0.0 0.064 13.3 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 ETO00072.1 - 0.043 13.8 0.3 0.091 12.8 0.1 1.7 2 1 0 2 2 1 0 AAA domain Zeta_toxin PF06414.12 ETO00072.1 - 0.089 12.1 0.0 0.14 11.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AIG1 PF04548.16 ETO00072.1 - 0.092 12.1 0.3 5.5 6.2 0.0 2.4 2 0 0 2 2 2 0 AIG1 family RNA_helicase PF00910.22 ETO00072.1 - 0.093 13.1 0.0 0.23 11.8 0.0 1.9 1 1 0 1 1 1 0 RNA helicase ATP-synt_ab PF00006.25 ETO00072.1 - 0.15 11.7 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain AAA_25 PF13481.6 ETO00072.1 - 0.16 11.6 0.0 0.2 11.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO00072.1 - 0.16 11.6 0.0 0.41 10.3 0.0 1.7 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_23 PF13476.6 ETO00072.1 - 0.36 11.3 2.6 0.3 11.6 0.7 2.0 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 ETO00072.1 - 0.9 8.9 4.8 3.5 7.0 0.2 3.0 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 ETO00073.1 - 3.1e-08 33.7 0.0 3.4e-08 33.6 0.0 1.0 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETO00073.1 - 0.0059 16.5 0.1 0.011 15.6 0.1 1.6 1 1 0 1 1 1 1 STI1 domain WD40 PF00400.32 ETO00074.1 - 1.8e-39 133.0 17.6 3.5e-12 46.6 0.3 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00074.1 - 4.5e-16 58.9 0.6 0.00017 21.8 0.1 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO00074.1 - 6.3e-07 28.7 0.0 0.37 9.7 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO00074.1 - 2.8e-06 26.3 2.8 0.34 9.5 0.0 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 SAND PF01342.21 ETO00074.1 - 4.9e-06 26.2 0.2 0.049 13.3 0.0 2.3 1 1 1 2 2 2 2 SAND domain WD40_like PF17005.5 ETO00074.1 - 3.9e-05 23.1 0.0 0.0042 16.4 0.0 2.1 1 1 1 2 2 2 1 WD40-like domain PD40 PF07676.12 ETO00074.1 - 9.9e-05 22.2 0.9 4.1 7.5 0.0 3.5 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat AcetylCoA_hyd_C PF13336.6 ETO00074.1 - 0.00047 20.1 3.5 1.6 8.6 0.1 3.0 1 1 2 3 3 3 2 Acetyl-CoA hydrolase/transferase C-terminal domain DUF5570 PF17731.1 ETO00074.1 - 0.00076 19.6 7.6 1.3 9.1 0.1 3.9 1 1 3 4 4 4 2 Family of unknown function (DUF5570) DUF727 PF05303.12 ETO00074.1 - 0.0017 18.4 0.0 7.3 6.7 0.0 3.0 1 1 1 3 3 3 1 Protein of unknown function (DUF727) SoxZ PF08770.11 ETO00074.1 - 0.0024 17.6 0.0 11 5.8 0.0 3.1 3 0 0 3 3 3 0 Sulphur oxidation protein SoxZ Cytochrom_D1 PF02239.16 ETO00074.1 - 0.0053 15.3 0.2 0.29 9.6 0.0 2.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain DUF1513 PF07433.11 ETO00074.1 - 0.0063 15.6 0.3 1.5 7.9 0.0 2.6 1 1 2 3 3 3 1 Protein of unknown function (DUF1513) Gmad1 PF10647.9 ETO00074.1 - 0.0072 16.1 0.0 3.8 7.2 0.0 2.7 1 1 2 3 3 3 1 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.9 ETO00074.1 - 0.045 13.4 2.9 22 4.8 0.1 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Reg_prop PF07494.11 ETO00074.1 - 0.063 13.5 0.5 45 4.8 0.0 3.5 3 0 0 3 3 3 0 Two component regulator propeller Me-amine-dh_H PF06433.11 ETO00074.1 - 0.067 12.0 0.0 2.3 7.0 0.0 2.2 1 1 2 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) DUF3841 PF12952.7 ETO00074.1 - 0.089 12.6 1.9 7.9 6.2 0.1 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF3841) Neur_chan_memb PF02932.16 ETO00075.1 - 0.44 10.6 4.3 0.11 12.6 0.3 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region WD40 PF00400.32 ETO00076.1 - 1.7e-26 91.9 18.7 1e-06 29.3 0.2 5.4 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00076.1 - 8.7e-13 48.4 0.2 0.066 13.5 0.0 4.2 4 0 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00076.1 - 7.3e-09 34.8 0.8 0.25 9.9 0.0 3.9 1 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00076.1 - 2.8e-06 26.9 0.7 0.00079 18.8 0.2 3.1 2 1 1 3 3 3 2 WD40-like domain CLIP_1 PF18322.1 ETO00076.1 - 0.072 13.2 5.1 1.1 9.3 0.8 2.8 2 0 0 2 2 2 0 Serine protease Clip domain PPAF-2 YlbE PF14003.6 ETO00077.1 - 0.0077 16.7 0.2 0.26 11.8 0.0 2.3 1 1 1 2 2 2 2 YlbE-like protein DUF913 PF06025.12 ETO00078.1 - 0.092 11.7 2.8 0.11 11.5 2.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 ETO00078.1 - 0.1 12.7 2.2 0.11 12.7 2.2 1.1 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.19 ETO00078.1 - 0.65 9.7 3.7 0.72 9.6 3.7 1.1 1 0 0 1 1 1 0 Connexin RRN3 PF05327.11 ETO00078.1 - 0.95 7.9 8.0 1.2 7.6 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Presenilin PF01080.17 ETO00078.1 - 1.2 7.8 5.3 1.5 7.5 5.3 1.1 1 0 0 1 1 1 0 Presenilin Vps52 PF04129.12 ETO00079.1 - 1.5e-18 66.9 7.4 2.1e-18 66.3 7.4 1.2 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 ETO00079.1 - 1.1e-05 24.1 10.2 1.6e-05 23.5 10.2 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec3 ATG16 PF08614.11 ETO00079.1 - 0.0025 18.1 2.6 0.0033 17.7 2.6 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 ETO00079.1 - 0.016 15.0 11.4 0.026 14.3 11.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) COG2 PF06148.11 ETO00079.1 - 0.029 14.4 7.4 0.29 11.2 7.3 2.3 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF2452 PF10504.9 ETO00079.1 - 0.036 13.5 1.0 0.068 12.6 1.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2452) HMMR_N PF15905.5 ETO00079.1 - 0.062 12.8 10.3 0.03 13.8 7.1 1.8 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Laminin_II PF06009.12 ETO00079.1 - 0.094 12.7 7.8 0.55 10.2 1.5 2.2 1 1 1 2 2 2 0 Laminin Domain II DUF1664 PF07889.12 ETO00079.1 - 0.11 12.6 5.2 0.13 12.3 2.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PLATZ PF04640.14 ETO00079.1 - 0.13 12.9 0.4 0.28 11.8 0.3 1.6 1 1 0 1 1 1 0 PLATZ transcription factor Fez1 PF06818.15 ETO00079.1 - 0.13 12.7 5.6 0.072 13.5 3.5 1.6 1 1 1 2 2 2 0 Fez1 Cob_adeno_trans PF01923.18 ETO00079.1 - 0.13 12.3 1.3 0.27 11.4 1.3 1.6 1 1 0 1 1 1 0 Cobalamin adenosyltransferase YlbD_coat PF14071.6 ETO00079.1 - 0.26 11.5 11.2 1.2 9.4 1.2 2.9 1 1 2 3 3 3 0 Putative coat protein RSS_P20 PF11757.8 ETO00079.1 - 0.44 11.0 7.9 0.2 12.1 3.9 2.1 1 1 1 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain Dynamin_N PF00350.23 ETO00079.1 - 0.86 9.6 6.0 0.34 10.9 1.0 2.1 1 1 1 2 2 2 0 Dynamin family COG5 PF10392.9 ETO00079.1 - 1 9.5 8.8 1 9.5 7.3 1.7 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Noelin-1 PF12308.8 ETO00079.1 - 1.2 9.2 5.0 0.38 10.8 1.1 2.1 2 1 0 2 2 2 0 Neurogenesis glycoprotein Cep57_MT_bd PF06657.13 ETO00079.1 - 1.5 9.3 8.4 0.6 10.6 4.5 2.2 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 zf-C4H2 PF10146.9 ETO00079.1 - 6.8 6.9 11.6 4.5 7.5 1.7 2.4 1 1 2 3 3 3 0 Zinc finger-containing protein WD40 PF00400.32 ETO00082.1 - 1.3e-14 54.3 7.5 5.3e-07 30.2 0.1 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00082.1 - 4.4e-05 23.7 0.1 0.026 14.8 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00082.1 - 0.0047 15.6 0.3 0.83 8.2 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF3292 PF11696.8 ETO00084.1 - 0.035 12.5 3.2 0.046 12.1 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Pneumo_M2 PF07380.11 ETO00084.1 - 0.054 13.8 0.5 3 8.2 0.1 2.4 2 0 0 2 2 2 0 Pneumovirus M2 protein NYD-SP28 PF14772.6 ETO00084.1 - 0.27 11.3 4.9 0.4 10.8 1.4 2.4 2 0 0 2 2 2 0 Sperm tail AAA_5 PF07728.14 ETO00085.1 - 2.3e-12 47.1 0.2 7.6e-11 42.2 0.1 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 ETO00085.1 - 0.0006 19.9 0.0 0.0063 16.6 0.0 2.1 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_3 PF07726.11 ETO00085.1 - 0.017 15.0 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ETO00085.1 - 0.083 12.3 0.0 0.2 11.0 0.0 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Connexin PF00029.19 ETO00087.1 - 1.6 8.4 5.5 2.8 7.7 5.5 1.5 1 0 0 1 1 1 0 Connexin AIF_C PF14721.6 ETO00087.1 - 7 7.0 6.9 17 5.8 6.3 1.8 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term WD40 PF00400.32 ETO00088.1 - 3.8e-21 75.0 2.1 6.7e-10 39.4 0.1 3.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00088.1 - 6.4e-08 32.8 0.1 0.03 14.6 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00088.1 - 0.0001 21.1 0.0 0.02 13.5 0.0 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO00088.1 - 0.0022 17.8 0.0 1.7 8.7 0.0 3.0 3 0 0 3 3 3 1 PQQ enzyme repeat WD40_like PF17005.5 ETO00088.1 - 0.0047 16.3 0.8 0.0084 15.5 0.4 1.5 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO00088.1 - 0.013 15.4 0.1 0.025 14.5 0.1 1.4 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO00088.1 - 0.016 14.2 0.0 0.032 13.2 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ETO00088.1 - 0.051 12.5 0.1 0.21 10.4 0.0 1.9 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain nos_propeller PF18764.1 ETO00088.1 - 0.14 12.0 0.0 31 4.6 0.0 2.9 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat DUF5083 PF16890.5 ETO00090.1 - 0.012 15.4 0.2 0.022 14.5 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5083) DUF1539 PF07560.11 ETO00090.1 - 0.2 11.8 5.1 0.14 12.2 1.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) Sipho_Gp157 PF05565.11 ETO00091.1 - 0.018 15.1 1.6 0.37 10.8 0.9 2.0 1 1 0 2 2 2 0 Siphovirus Gp157 A_deamin PF02137.18 ETO00093.1 - 0.13 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain Read-through PF16814.5 ETO00094.1 - 0.084 12.7 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Read-through domain Prok-RING_4 PF14447.6 ETO00097.1 - 0.35 10.7 8.3 4 7.4 1.5 3.3 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETO00097.1 - 5.2 7.0 8.7 10 6.1 0.0 3.3 4 0 0 4 4 4 0 Zinc finger, C3HC4 type (RING finger) EzrA PF06160.12 ETO00099.1 - 0.0026 16.0 3.0 0.0038 15.5 2.9 1.2 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Dsl1_C PF11989.8 ETO00099.1 - 0.0087 15.8 0.9 0.013 15.2 0.9 1.2 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal PPR_2 PF13041.6 ETO00100.1 - 0.00035 20.7 0.2 0.0006 20.0 0.2 1.4 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 ETO00100.1 - 0.022 15.0 0.1 0.041 14.1 0.1 1.5 1 0 0 1 1 1 0 PPR repeat PPR_1 PF12854.7 ETO00100.1 - 0.13 12.0 0.1 0.2 11.4 0.1 1.4 1 0 0 1 1 1 0 PPR repeat RsbU_N PF08673.10 ETO00101.1 - 0.059 13.5 0.3 0.32 11.1 0.2 2.3 2 0 0 2 2 2 0 Phosphoserine phosphatase RsbU, N-terminal domain SRI PF08236.11 ETO00101.1 - 0.099 12.8 1.3 2.5 8.4 0.1 3.1 2 0 0 2 2 2 0 SRI (Set2 Rpb1 interacting) domain DUF2610 PF11020.8 ETO00102.1 - 0.0032 17.3 0.1 0.0058 16.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2610) DUF5121 PF17165.4 ETO00102.1 - 0.016 15.6 0.4 0.026 15.0 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5121) DUF5605 PF18310.1 ETO00102.1 - 0.1 12.5 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) Neuromodulin_N PF10580.9 ETO00102.1 - 0.17 11.7 0.6 0.17 11.7 0.6 1.6 2 0 0 2 2 2 0 Gap junction protein N-terminal region TPR_12 PF13424.6 ETO00104.1 - 1.4e-25 89.4 0.4 2.9e-15 56.3 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00104.1 - 5e-17 61.2 0.1 3.4e-06 26.7 0.0 4.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00104.1 - 1.7e-11 43.3 6.5 0.00094 19.1 0.5 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00104.1 - 2e-11 43.1 0.4 0.0035 17.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00104.1 - 2.6e-11 42.8 15.7 3.2e-06 26.7 1.1 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00104.1 - 1.4e-07 31.1 7.4 0.00022 21.2 1.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00104.1 - 3.4e-05 23.9 0.2 0.63 10.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00104.1 - 0.00012 21.6 8.4 0.025 14.2 0.2 3.9 3 1 1 4 4 4 2 TPR repeat TPR_6 PF13174.6 ETO00104.1 - 0.00032 21.1 0.1 12 6.8 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat HisK_sensor PF18698.1 ETO00104.1 - 0.0054 17.1 1.9 0.0054 17.1 1.9 2.7 2 1 1 3 3 3 1 Histidine kinase sensor domain TPR_16 PF13432.6 ETO00104.1 - 0.069 13.8 0.0 38 5.1 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO00104.1 - 0.084 12.4 0.1 0.084 12.4 0.1 2.9 2 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like Phage_ABA_S PF18066.1 ETO00104.1 - 0.43 11.3 5.5 0.3 11.8 1.0 2.7 2 1 0 2 2 2 0 Phage ABA sandwich domain DUF357 PF04010.13 ETO00104.1 - 0.51 10.5 2.4 11 6.2 0.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF357) DUF5113 PF17140.4 ETO00104.1 - 0.93 9.3 6.4 8.6 6.1 0.0 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF5113) WD40 PF00400.32 ETO00105.1 - 7.3e-34 115.3 6.1 1.2e-09 38.7 0.7 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00105.1 - 5.8e-16 58.6 0.0 0.0046 17.2 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00105.1 - 1.8e-08 33.5 1.5 0.0094 14.6 0.0 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO00105.1 - 3.8e-07 29.9 0.6 0.91 9.5 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO00105.1 - 1.9e-06 27.1 0.0 1.2 8.1 0.0 3.9 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO00105.1 - 2.8e-06 27.3 0.0 0.00046 20.1 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 ETO00105.1 - 7.5e-05 22.3 2.4 1 9.1 0.1 4.3 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Str_synth PF03088.16 ETO00105.1 - 0.00031 20.8 0.0 1.2 9.4 0.0 3.4 3 1 1 4 4 4 2 Strictosidine synthase DUF5570 PF17731.1 ETO00105.1 - 0.00039 20.5 1.9 6.2 6.9 0.1 3.5 1 1 3 4 4 4 2 Family of unknown function (DUF5570) DUF5046 PF16465.5 ETO00105.1 - 0.0033 16.9 0.0 0.0056 16.2 0.0 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF5046) WD40_like PF17005.5 ETO00105.1 - 0.0074 15.6 0.0 0.27 10.5 0.0 2.6 2 1 1 3 3 3 2 WD40-like domain PALB2_WD40 PF16756.5 ETO00105.1 - 0.023 13.7 0.6 13 4.6 0.0 3.5 2 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO00105.1 - 0.06 11.9 0.0 11 4.5 0.0 2.7 1 1 1 2 2 2 0 Cytochrome D1 heme domain Lactonase PF10282.9 ETO00105.1 - 0.12 11.5 0.0 0.26 10.5 0.0 1.8 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller nos_propeller PF18764.1 ETO00105.1 - 0.13 12.1 0.1 11 6.1 0.0 3.3 2 1 0 4 4 4 0 Nitrous oxide reductase propeller repeat MCM PF00493.23 ETO00106.1 - 2.8e-31 108.4 0.0 1.3e-30 106.2 0.0 1.9 1 1 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 ETO00106.1 - 3.4e-13 49.8 2.9 5.6e-13 49.1 2.9 1.3 1 0 0 1 1 1 1 MCM AAA-lid domain AAA_5 PF07728.14 ETO00106.1 - 5.1e-06 26.5 0.0 0.00014 21.9 0.0 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO00106.1 - 0.0012 19.3 1.2 0.0058 17.0 0.2 2.2 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETO00106.1 - 0.0015 18.8 1.7 0.046 14.0 0.1 2.8 3 0 0 3 3 3 1 AAA domain AAA_7 PF12775.7 ETO00106.1 - 0.013 15.0 0.2 0.056 12.9 0.1 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region Mg_chelatase PF01078.21 ETO00106.1 - 0.035 13.5 0.0 0.17 11.3 0.0 2.0 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 ETO00106.1 - 0.039 14.4 0.2 0.47 10.9 0.1 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETO00106.1 - 0.048 13.4 0.1 0.2 11.4 0.1 2.0 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO00106.1 - 0.055 13.9 0.2 4.2 7.8 0.0 2.5 2 0 0 2 2 2 0 RNA helicase TniB PF05621.11 ETO00106.1 - 0.066 12.6 0.0 7.3 6.0 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein AAA_19 PF13245.6 ETO00106.1 - 0.19 12.0 0.3 1.1 9.5 0.0 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO00106.1 - 0.71 10.4 2.4 2 8.9 0.0 2.7 2 1 1 3 3 3 0 ABC transporter SdpI PF13630.6 ETO00107.1 - 0.49 10.6 5.6 0.1 12.7 1.5 2.0 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF4131 PF13567.6 ETO00107.1 - 0.5 10.0 11.8 0.024 14.3 3.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) PrgI PF12666.7 ETO00107.1 - 0.83 10.4 6.7 0.91 10.3 3.3 2.3 2 1 0 2 2 2 0 PrgI family protein PI3_PI4_kinase PF00454.27 ETO00108.1 - 0.00083 19.2 0.0 0.0018 18.1 0.0 1.6 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Peptidase_S10 PF00450.22 ETO00109.1 - 1.4e-58 199.3 7.6 3.2e-56 191.5 7.6 3.0 1 1 0 1 1 1 1 Serine carboxypeptidase CAP_GLY PF01302.25 ETO00110.1 - 3.4e-21 75.0 0.1 5.9e-21 74.3 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 ETO00110.1 - 8.7e-13 48.5 0.5 2.3e-12 47.2 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain T6_Ig_like PF18002.1 ETO00110.1 - 0.0014 18.5 0.2 0.0021 18.0 0.2 1.3 1 0 0 1 1 1 1 T6 antigen Ig like domain DUF1043 PF06295.12 ETO00110.1 - 0.028 14.4 2.0 0.058 13.4 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) EMC3_TMCO1 PF01956.16 ETO00110.1 - 0.2 11.4 0.0 0.25 11.0 0.0 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like PNPase PF03726.14 ETO00110.1 - 0.45 11.0 4.0 0.79 10.3 4.0 1.3 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain WD40 PF00400.32 ETO00111.1 - 1.7e-18 66.6 8.4 6.1e-06 26.9 0.1 4.7 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00111.1 - 3.2e-06 27.4 0.6 0.47 10.8 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00111.1 - 1.9e-05 23.5 0.5 0.17 10.5 0.0 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00111.1 - 0.0096 15.3 3.0 0.1 11.9 0.7 2.5 1 1 1 2 2 2 2 WD40-like domain RicinB_lectin_2 PF14200.6 ETO00111.1 - 0.043 14.5 1.4 2.5 8.9 0.2 2.4 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Peptidase_C14 PF00656.22 ETO00112.1 - 1.1e-12 48.5 0.2 1.2e-12 48.3 0.2 1.1 1 0 0 1 1 1 1 Caspase domain CO_dh PF02552.16 ETO00112.1 - 0.038 13.8 0.4 0.06 13.1 0.4 1.2 1 0 0 1 1 1 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit JmjC PF02373.22 ETO00113.1 - 0.084 13.3 0.2 1.4 9.3 0.0 2.1 2 0 0 2 2 2 0 JmjC domain, hydroxylase PUB PF09409.10 ETO00114.1 - 0.052 13.5 0.6 0.2 11.6 0.6 2.0 1 1 0 1 1 1 0 PUB domain PIP5K PF01504.18 ETO00116.1 - 4.9e-37 127.7 2.1 5e-27 94.8 1.1 2.6 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Cpn60_TCP1 PF00118.24 ETO00116.1 - 1.6e-28 99.6 0.2 3.9e-28 98.3 0.0 1.6 2 0 0 2 2 2 1 TCP-1/cpn60 chaperonin family NACHT PF05729.12 ETO00117.1 - 0.00058 19.8 0.1 0.00066 19.6 0.1 1.2 1 0 0 1 1 1 1 NACHT domain p450 PF00067.22 ETO00118.1 - 2.2e-59 201.5 0.0 2.3e-59 201.4 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 NACHT PF05729.12 ETO00119.1 - 0.033 14.1 0.0 0.11 12.4 0.1 1.8 2 0 0 2 2 2 0 NACHT domain FtsK_SpoIIIE PF01580.18 ETO00119.1 - 0.057 12.8 0.0 0.9 8.8 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Glyco_transf_10 PF00852.19 ETO00122.1 - 0.0012 18.6 0.7 0.0021 17.8 0.4 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term DUF3819 PF12842.7 ETO00123.1 - 0.029 14.3 0.3 0.049 13.6 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) DSX_dimer PF08828.10 ETO00123.1 - 0.06 13.0 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Doublesex dimerisation domain Toxin_30 PF08117.11 ETO00123.1 - 0.12 12.7 6.1 0.2 11.9 6.1 1.3 1 0 0 1 1 1 0 Ptu family PUB PF09409.10 ETO00124.1 - 0.0045 16.9 1.2 0.04 13.8 1.2 2.0 1 1 0 1 1 1 1 PUB domain Aph-1 PF06105.12 ETO00124.1 - 0.042 13.3 1.1 0.15 11.4 1.1 1.8 1 1 0 1 1 1 0 Aph-1 protein RP853 PF17542.2 ETO00125.1 - 0.023 13.8 1.3 0.029 13.5 1.3 1.2 1 0 0 1 1 1 0 Uncharacterized RP853 DUF3744 PF12558.8 ETO00125.1 - 0.15 12.9 4.5 0.8 10.5 0.3 2.3 2 1 0 2 2 2 0 ATP-binding cassette cobalt transporter AP3D1 PF06375.11 ETO00127.1 - 3.6 7.8 18.4 0.054 13.7 11.9 1.5 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Ribosom_S12_S23 PF00164.25 ETO00128.1 - 7e-45 151.3 0.9 1.8e-42 143.5 0.9 2.4 1 1 0 1 1 1 1 Ribosomal protein S12/S23 DUF2956 PF11169.8 ETO00133.1 - 0.05 13.8 7.4 0.2 11.9 2.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Exo_endo_phos_2 PF14529.6 ETO00136.1 - 2.1e-08 34.0 2.2 8.4e-08 32.1 0.3 2.9 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 ETO00136.1 - 9.6e-07 28.5 1.5 1e-06 28.5 0.1 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 ETO00136.1 - 0.04 13.4 1.7 0.12 11.9 0.3 2.1 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family Lac_bphage_repr PF06543.12 ETO00138.1 - 0.035 14.1 1.0 0.13 12.2 0.5 2.1 2 0 0 2 2 2 0 Lactococcus bacteriophage repressor DUF2408 PF10303.9 ETO00138.1 - 0.045 14.3 4.5 0.053 14.1 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF4709 PF15821.5 ETO00138.1 - 0.066 13.5 5.4 0.12 12.6 1.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) G10 PF01125.17 ETO00138.1 - 0.1 12.4 3.5 0.81 9.4 0.5 2.2 2 0 0 2 2 2 0 G10 protein DUF4175 PF13779.6 ETO00139.1 - 0.043 11.7 5.0 0.047 11.6 5.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) NDUF_B5 PF09781.9 ETO00139.1 - 0.096 12.3 2.5 0.044 13.4 0.8 1.3 1 1 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit DUF5362 PF17319.2 ETO00139.1 - 0.13 12.2 0.6 0.23 11.3 0.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5362) Sec62 PF03839.16 ETO00139.1 - 0.98 8.9 8.8 1.1 8.8 8.8 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 TPR_11 PF13414.6 ETO00140.1 - 5.5e-19 67.6 20.6 0.00013 21.6 0.2 4.2 3 1 1 4 4 4 4 TPR repeat TPR_17 PF13431.6 ETO00140.1 - 2.8e-13 49.2 21.5 0.00055 20.1 1.6 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00140.1 - 6.3e-13 48.4 5.5 0.014 16.2 0.4 4.2 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00140.1 - 3.7e-11 42.3 13.4 0.0014 18.7 1.8 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00140.1 - 1.3e-10 40.5 27.7 0.0039 17.2 0.5 5.9 5 3 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00140.1 - 2e-10 40.0 25.5 0.0018 18.0 0.2 6.0 4 2 0 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO00140.1 - 6e-09 36.3 11.0 0.0044 17.5 1.4 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO00140.1 - 1.2e-07 31.9 15.2 0.0004 20.6 5.1 3.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00140.1 - 2.4e-06 28.1 15.5 0.0011 19.6 1.6 3.8 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 ETO00140.1 - 6.2e-05 23.1 3.8 0.00074 19.6 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00140.1 - 0.00029 21.3 6.1 11 6.9 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO00140.1 - 0.0071 16.4 4.2 0.16 12.1 0.1 3.3 2 1 1 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 ETO00140.1 - 0.019 14.9 7.1 21 5.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat eIF-3c_N PF05470.12 ETO00140.1 - 0.023 13.0 2.6 0.027 12.8 2.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Cor1 PF04803.12 ETO00140.1 - 0.11 12.7 0.2 0.16 12.2 0.2 1.4 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region L31 PF09784.9 ETO00140.1 - 0.14 12.6 1.2 1.5 9.3 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 Pec_lyase_N PF04431.13 ETO00140.1 - 0.15 12.3 1.8 0.63 10.3 0.4 2.4 2 0 0 2 2 2 0 Pectate lyase, N terminus FAT PF02259.23 ETO00140.1 - 0.28 10.3 6.3 1.1 8.4 2.4 2.2 1 1 1 2 2 2 0 FAT domain Mucin PF01456.17 ETO00141.1 - 5.8 6.9 17.0 7.3 6.6 17.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein APC_u14 PF16635.5 ETO00142.1 - 0.38 11.3 6.4 0.074 13.6 2.3 1.8 2 0 0 2 2 2 0 Unstructured region on APC between SAMP and APC_crr Pkinase PF00069.25 ETO00143.1 - 5.8e-08 32.4 0.1 8.6e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00143.1 - 0.02 14.2 0.1 0.028 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase AAA_9 PF12781.7 ETO00144.1 - 0.017 14.3 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 ATP-binding dynein motor region DUF3819 PF12842.7 ETO00145.1 - 0.017 15.0 0.2 0.028 14.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) DUF1462 PF07315.11 ETO00146.1 - 0.043 14.1 0.1 0.058 13.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1462) SAM_2 PF07647.17 ETO00147.1 - 4.5e-14 52.3 1.1 1.9e-09 37.5 0.3 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO00147.1 - 5.8e-11 42.7 0.6 2.1e-07 31.3 0.1 2.5 2 1 0 2 2 2 2 SAM domain (Sterile alpha motif) SPRY PF00622.28 ETO00148.1 - 0.0019 18.3 0.2 0.0019 18.3 0.2 2.2 3 0 0 3 3 3 1 SPRY domain fn3 PF00041.21 ETO00148.1 - 0.0071 16.7 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Fibronectin type III domain CNDH2_C PF16858.5 ETO00148.1 - 0.0087 16.0 7.4 0.014 15.3 7.4 1.3 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 ETO00148.1 - 1.5 7.0 10.0 2.6 6.3 10.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO00148.1 - 2.6 6.7 5.7 27 3.4 4.4 2.1 2 0 0 2 2 2 0 Presenilin Pkinase PF00069.25 ETO00149.1 - 1.7e-62 211.2 0.0 2.1e-62 210.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00149.1 - 8.8e-26 90.7 0.0 1.1e-25 90.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO00149.1 - 2.4e-05 23.3 0.0 3.4e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO00149.1 - 0.0063 15.9 0.0 1.8 7.8 0.0 2.2 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ETO00149.1 - 0.0085 16.0 0.0 0.027 14.4 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO00149.1 - 0.038 13.4 0.0 0.078 12.3 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RUN PF02759.19 ETO00150.1 - 0.0097 15.9 0.7 0.013 15.5 0.7 1.3 1 0 0 1 1 1 1 RUN domain ARS2 PF04959.13 ETO00151.1 - 0.035 14.5 0.1 0.042 14.2 0.1 1.1 1 0 0 1 1 1 0 Arsenite-resistance protein 2 Lipoprotein_19 PF13617.6 ETO00151.1 - 0.052 13.3 0.9 0.31 10.9 0.0 2.4 2 0 0 2 2 2 0 YnbE-like lipoprotein Nab6_mRNP_bdg PF10567.9 ETO00152.1 - 0.0045 16.5 0.1 0.005 16.4 0.1 1.0 1 0 0 1 1 1 1 RNA-recognition motif Spt20 PF12090.8 ETO00152.1 - 0.0099 15.5 15.5 0.011 15.4 15.5 1.1 1 0 0 1 1 1 1 Spt20 family Oleosin PF01277.17 ETO00152.1 - 0.16 11.7 0.0 0.21 11.4 0.0 1.1 1 0 0 1 1 1 0 Oleosin Band_3_cyto PF07565.13 ETO00152.1 - 0.34 10.7 3.7 0.37 10.6 3.7 1.0 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4834 PF16118.5 ETO00152.1 - 0.48 11.4 5.8 0.58 11.2 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DivIC PF04977.15 ETO00152.1 - 0.55 10.0 8.5 0.91 9.3 8.5 1.4 1 0 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.6 ETO00152.1 - 0.65 9.3 4.5 0.6 9.4 4.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 ETO00152.1 - 1.2 7.8 3.6 1.2 7.8 3.6 1.0 1 0 0 1 1 1 0 Presenilin MITF_TFEB_C_3_N PF15951.5 ETO00152.1 - 1.9 9.1 20.2 24 5.5 0.0 2.1 2 0 0 2 2 2 0 MITF/TFEB/TFEC/TFE3 N-terminus DUF2722 PF10846.8 ETO00152.1 - 2.3 7.1 17.1 2.7 6.8 17.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) ATP-synt_E PF05680.12 ETO00152.1 - 3.3 8.1 7.5 4.5 7.7 7.5 1.1 1 0 0 1 1 1 0 ATP synthase E chain Med3 PF11593.8 ETO00152.1 - 6.8 5.8 16.6 7.8 5.6 16.6 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FERM_C PF09380.10 ETO00154.1 - 0.0047 17.3 0.5 0.0073 16.7 0.5 1.5 1 1 0 1 1 1 1 FERM C-terminal PH-like domain SBDS_C PF09377.10 ETO00154.1 - 0.018 15.1 1.8 0.024 14.6 1.8 1.3 1 0 0 1 1 1 0 SBDS protein C-terminal domain SAP PF02037.27 ETO00154.1 - 0.039 13.7 0.0 0.096 12.5 0.0 1.6 1 0 0 1 1 1 0 SAP domain U-box PF04564.15 ETO00155.1 - 0.0063 16.7 1.2 0.14 12.4 0.5 2.7 2 0 0 2 2 2 1 U-box domain Peptidase_A17 PF05380.13 ETO00155.1 - 0.038 14.0 10.0 0.12 12.4 0.1 2.4 1 1 1 2 2 2 0 Pao retrotransposon peptidase SH3_19 PF18597.1 ETO00155.1 - 0.13 12.1 0.0 0.32 10.9 0.0 1.6 1 0 0 1 1 1 0 Myosin X N-terminal SH3 domain Stk19 PF10494.9 ETO00155.1 - 2 8.0 6.4 6.3 6.4 6.4 1.7 1 1 0 1 1 1 0 Serine-threonine protein kinase 19 WD40 PF00400.32 ETO00156.1 - 2.2e-63 208.7 28.3 1.9e-10 41.2 0.4 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00156.1 - 5.8e-20 71.4 6.9 0.00019 21.7 0.1 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO00156.1 - 8e-13 48.0 2.0 0.1 11.5 0.0 5.8 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO00156.1 - 1.8e-07 30.8 1.7 0.0025 17.2 0.0 3.3 2 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO00156.1 - 6e-06 25.0 1.4 0.073 11.6 0.0 3.8 1 1 3 4 4 4 4 Cytochrome D1 heme domain Nup160 PF11715.8 ETO00156.1 - 1.3e-05 24.0 11.5 1.1 7.8 0.1 5.8 1 1 5 6 6 6 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO00156.1 - 0.16 12.1 3.8 5.3 7.2 0.0 3.8 1 1 3 4 4 4 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO00156.1 - 0.31 11.0 2.5 84 3.3 0.3 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat MazG PF03819.17 ETO00158.1 - 0.025 14.8 0.0 0.039 14.1 0.0 1.3 1 0 0 1 1 1 0 MazG nucleotide pyrophosphohydrolase domain DUF3385 PF11865.8 ETO00158.1 - 0.078 12.9 0.0 0.62 10.0 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3385) SAM_1 PF00536.30 ETO00159.1 - 0.088 13.3 0.2 0.38 11.2 0.2 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) TPR_1 PF00515.28 ETO00162.1 - 1.5e-10 40.4 6.9 2.1e-06 27.3 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00162.1 - 5.9e-10 38.5 3.5 7.8e-05 22.5 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO00162.1 - 1.6e-08 34.7 3.0 2.5e-06 27.7 0.4 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00162.1 - 6.4e-06 25.9 0.3 0.012 15.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO00162.1 - 3.5e-05 23.9 3.6 3.5e-05 23.9 3.6 1.9 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ETO00162.1 - 0.00023 20.9 0.7 0.54 10.4 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00162.1 - 0.00026 20.9 6.2 0.00064 19.7 0.4 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00162.1 - 0.00053 20.5 0.2 0.13 13.0 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat Sigma_reg_N PF13800.6 ETO00162.1 - 0.00055 20.2 0.7 0.00055 20.2 0.7 1.9 2 0 0 2 2 2 1 Sigma factor regulator N-terminal TPR_14 PF13428.6 ETO00162.1 - 0.001 19.7 0.0 1.5 9.8 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00162.1 - 0.0011 19.2 4.2 0.13 12.7 0.2 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_15 PF13429.6 ETO00162.1 - 0.0024 17.1 0.1 0.003 16.8 0.1 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat SNAP PF14938.6 ETO00162.1 - 0.003 17.0 3.2 0.0045 16.5 3.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 ETO00162.1 - 0.015 15.0 2.6 0.29 10.8 2.7 2.2 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TPR_11 PF13414.6 ETO00162.1 - 0.019 14.6 9.1 0.35 10.6 1.1 2.7 1 1 1 2 2 2 0 TPR repeat TPR_19 PF14559.6 ETO00162.1 - 0.022 15.2 0.0 0.044 14.3 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat PIG-P PF08510.12 ETO00162.1 - 0.029 14.3 2.7 0.029 14.3 2.7 1.8 1 1 0 2 2 2 0 PIG-P TPR_9 PF13371.6 ETO00162.1 - 0.084 13.0 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00162.1 - 0.16 12.6 0.0 7.7 7.3 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Mt_ATP-synt_D PF05873.12 ETO00164.1 - 0.074 12.9 3.5 0.14 12.0 0.1 2.8 2 1 1 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) DUF4844 PF16133.5 ETO00164.1 - 2.9 8.5 8.3 6 7.5 0.2 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4844) NBD94 PF16830.5 ETO00164.1 - 3 8.3 16.5 0.7 10.3 2.0 3.3 3 0 0 3 3 3 0 Nucleotide-Binding Domain 94 of RH REPA_OB_2 PF16900.5 ETO00165.1 - 0.17 11.8 1.5 3.7 7.5 1.5 2.1 1 1 0 1 1 1 0 Replication protein A OB domain BPTA PF17044.5 ETO00166.1 - 0.0045 16.9 3.2 0.0055 16.6 3.2 1.2 1 0 0 1 1 1 1 Borrelial persistence in ticks protein A Seryl_tRNA_N PF02403.22 ETO00167.1 - 0.057 13.6 5.5 0.066 13.5 0.4 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Spore_III_AF PF09581.10 ETO00168.1 - 0.17 11.9 6.9 0.29 11.1 6.9 1.4 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Peptidase_C37 PF05416.12 ETO00168.1 - 0.39 9.2 8.7 0.47 8.9 8.7 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Jak1_Phl PF17887.1 ETO00168.1 - 1.3 9.0 20.7 2.1 8.3 10.8 2.2 1 1 0 2 2 2 0 Jak1 pleckstrin homology-like domain DUF2615 PF11027.8 ETO00168.1 - 3.3 7.9 6.0 1.1 9.5 0.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) DUF4770 PF15994.5 ETO00168.1 - 5.6 7.2 16.5 0.17 12.1 8.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4770) DUF2358 PF10184.9 ETO00169.1 - 0.051 13.9 0.1 0.11 12.8 0.0 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) Pox_Ag35 PF03286.14 ETO00170.1 - 0.0068 16.2 0.5 0.0083 15.9 0.5 1.1 1 0 0 1 1 1 1 Pox virus Ag35 surface protein Menin PF05053.13 ETO00170.1 - 0.071 11.5 4.5 0.083 11.2 4.5 1.2 1 0 0 1 1 1 0 Menin DUF4834 PF16118.5 ETO00170.1 - 0.21 12.5 1.8 0.33 11.9 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Corazonin PF17308.2 ETO00170.1 - 0.41 11.0 11.7 0.69 10.3 11.7 1.4 1 0 0 1 1 1 0 Pro-corazonin Secretin_N_2 PF07655.13 ETO00170.1 - 0.65 10.6 12.1 1 10.0 12.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain NOA36 PF06524.12 ETO00170.1 - 1.7 7.9 7.6 1.9 7.7 7.6 1.1 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO00170.1 - 1.8 9.0 5.3 2.6 8.5 5.3 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3891 PF13030.6 ETO00171.1 - 0.058 13.2 0.0 0.069 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) Peptidase_M1_N PF17900.1 ETO00172.1 - 0.0014 18.9 0.0 0.0015 18.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain WD40 PF00400.32 ETO00174.1 - 9.7e-16 57.9 8.4 7.6e-08 32.9 0.7 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO00174.1 - 4.4e-05 22.3 1.1 0.003 16.3 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00174.1 - 0.0013 18.2 0.7 0.0022 17.4 0.7 1.5 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO00174.1 - 0.0038 17.5 0.0 0.085 13.2 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF5345 PF17280.2 ETO00175.1 - 0.79 9.7 6.7 3.1 7.8 0.0 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5345) U-box PF04564.15 ETO00176.1 - 1.1e-11 44.7 1.2 7.8e-11 42.0 0.0 2.7 2 1 0 2 2 2 1 U-box domain Cbl_N2 PF02761.14 ETO00176.1 - 0.23 12.2 7.3 0.22 12.3 1.8 2.9 1 1 2 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain FliJ PF02050.16 ETO00176.1 - 4.4 7.5 18.4 1.8 8.8 4.2 2.9 2 1 1 3 3 3 0 Flagellar FliJ protein Kelch_6 PF13964.6 ETO00177.1 - 1.6e-07 31.3 0.5 1.1 9.7 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO00177.1 - 0.0016 17.9 0.1 0.67 9.6 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO00177.1 - 0.0022 17.9 0.2 1.9 8.6 0.1 4.0 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO00177.1 - 0.0058 16.9 0.1 0.25 11.7 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00177.1 - 0.056 13.4 0.0 4.1 7.5 0.0 3.4 3 0 0 3 3 3 0 Kelch motif ZZ PF00569.17 ETO00179.1 - 0.015 15.1 6.4 0.015 15.1 6.4 2.5 1 1 1 2 2 2 0 Zinc finger, ZZ type PolC_DP2 PF03833.13 ETO00179.1 - 0.56 8.0 4.9 0.6 7.9 4.9 1.0 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 VWA_N2 PF16164.5 ETO00179.1 - 4.1 7.6 8.9 0.46 10.7 4.3 1.7 1 1 1 2 2 2 0 VWA N-terminal Rubredoxin_2 PF18073.1 ETO00179.1 - 7.2 6.4 14.2 3.6 7.4 3.0 3.0 3 0 0 3 3 3 0 Rubredoxin metal binding domain DNA_pol3_beta_3 PF02768.15 ETO00180.1 - 0.0054 16.6 2.3 2.2 8.1 0.4 3.1 1 1 2 3 3 3 2 DNA polymerase III beta subunit, C-terminal domain SOGA PF11365.8 ETO00180.1 - 0.079 14.1 3.9 0.44 11.7 3.9 2.2 1 1 0 1 1 1 0 Protein SOGA SOGA PF11365.8 ETO00181.1 - 0.16 13.1 4.0 0.68 11.1 3.6 2.2 1 1 0 1 1 1 0 Protein SOGA DUF3822 PF12864.7 ETO00182.1 - 0.036 13.3 0.0 0.042 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3822) GTP_EFTU_D2 PF03144.25 ETO00182.1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Elongation factor Tu domain 2 zf-TRAF PF02176.18 ETO00185.1 - 1.7e-05 25.4 1.5 3.2e-05 24.5 1.5 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger FAM76 PF16046.5 ETO00185.1 - 0.0042 16.5 3.1 0.0045 16.4 3.1 1.1 1 0 0 1 1 1 1 FAM76 protein DUF484 PF04340.12 ETO00185.1 - 0.022 14.4 0.8 0.025 14.3 0.8 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF484 YabA PF06156.13 ETO00185.1 - 0.056 14.1 4.9 0.072 13.7 4.9 1.2 1 0 0 1 1 1 0 Initiation control protein YabA zf-TRAF_2 PF15965.5 ETO00185.1 - 0.062 13.8 0.4 0.1 13.0 0.4 1.4 1 0 0 1 1 1 0 TRAF-like zinc-finger DUF3573 PF12097.8 ETO00185.1 - 0.089 11.6 1.1 0.089 11.6 1.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) MRPL52 PF18699.1 ETO00185.1 - 0.41 10.9 5.7 0.54 10.5 5.7 1.2 1 0 0 1 1 1 0 Mitoribosomal protein mL52 AAA_7 PF12775.7 ETO00186.1 - 0.0057 16.2 0.1 0.012 15.1 0.0 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region Hydrolase_3 PF08282.12 ETO00186.1 - 0.039 13.7 0.0 0.046 13.5 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase tRNA-Thr_ED PF08915.11 ETO00188.1 - 0.24 11.5 4.0 0.4 10.8 4.0 1.3 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase DUF809 PF05663.11 ETO00188.1 - 0.6 10.3 2.5 1 9.5 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF809) CENP-N PF05238.13 ETO00189.1 - 0.26 10.6 14.5 0.31 10.3 14.5 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Presenilin PF01080.17 ETO00189.1 - 0.93 8.2 22.6 1.1 7.9 22.6 1.1 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 ETO00189.1 - 1 8.0 17.0 1.3 7.8 17.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 ETO00189.1 - 1.1 9.2 9.6 1.5 8.8 9.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4778 PF16008.5 ETO00189.1 - 2.1 8.3 15.0 2.9 7.8 15.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) XRN_M PF17846.1 ETO00189.1 - 2.3 7.1 15.4 3.3 6.6 15.4 1.3 1 0 0 1 1 1 0 Xrn1 helical domain PI3K_1B_p101 PF10486.9 ETO00189.1 - 5.6 4.6 20.6 7.3 4.2 20.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Mitofilin PF09731.9 ETO00189.1 - 5.6 5.7 32.6 7.1 5.3 32.6 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF2151 PF10221.9 ETO00189.1 - 5.9 5.4 17.3 8.9 4.8 17.3 1.3 1 0 0 1 1 1 0 Cell cycle and development regulator PIEZO PF15917.5 ETO00189.1 - 6 6.3 17.3 8.1 5.9 17.3 1.2 1 0 0 1 1 1 0 Piezo UPF0524 PF15823.5 ETO00189.1 - 6.9 6.0 12.0 9.6 5.5 12.0 1.2 1 0 0 1 1 1 0 UPF0524 of C3orf70 Hid1 PF12722.7 ETO00189.1 - 7.1 4.6 20.7 8.5 4.4 20.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rgp1 PF08737.10 ETO00189.1 - 9 5.3 16.0 11 5.0 16.0 1.1 1 0 0 1 1 1 0 Rgp1 RhoGAP PF00620.27 ETO00190.1 - 0.011 15.6 0.0 0.023 14.5 0.0 1.6 1 0 0 1 1 1 0 RhoGAP domain P_proprotein PF01483.20 ETO00190.1 - 0.18 11.8 0.5 4 7.5 0.2 2.5 2 0 0 2 2 2 0 Proprotein convertase P-domain DUF2457 PF10446.9 ETO00190.1 - 2.3 7.3 9.3 3.6 6.6 9.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) LEDGF PF11467.8 ETO00191.1 - 0.031 13.9 0.1 0.042 13.5 0.1 1.3 1 0 0 1 1 1 0 Lens epithelium-derived growth factor (LEDGF) RNA_pol_Rpb5_C PF01191.19 ETO00191.1 - 0.032 14.1 0.4 0.051 13.5 0.4 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain DUF5333 PF17267.2 ETO00191.1 - 0.061 13.5 0.3 6.1 7.1 0.0 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5333) PRE_C2HC PF07530.11 ETO00191.1 - 0.78 9.9 3.9 0.2 11.8 0.4 1.8 2 1 0 2 2 2 0 Associated with zinc fingers DUF2052 PF09747.9 ETO00192.1 - 0.012 15.8 4.9 0.016 15.4 4.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Connexin PF00029.19 ETO00192.1 - 8.9 6.0 7.9 1.9e+02 1.7 7.9 2.0 1 1 0 1 1 1 0 Connexin WD40 PF00400.32 ETO00193.1 - 9.2e-22 76.9 2.0 1.2e-08 35.4 0.0 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00193.1 - 0.0012 19.0 0.0 0.33 11.3 0.0 2.6 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00193.1 - 0.12 11.0 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 MAS20 PF02064.15 ETO00196.1 - 0.048 13.7 3.8 0.06 13.4 3.8 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor SR-25 PF10500.9 ETO00196.1 - 0.051 13.2 8.1 0.066 12.8 8.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein OATP PF03137.20 ETO00196.1 - 0.24 9.7 2.3 0.28 9.4 2.3 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Gram_pos_anchor PF00746.21 ETO00196.1 - 0.78 9.7 0.1 0.78 9.7 0.1 2.6 2 0 0 2 2 2 0 LPXTG cell wall anchor motif Baculo_LEF5_C PF11792.8 ETO00198.1 - 0.011 15.3 0.4 0.048 13.3 0.1 2.1 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain DUF3496 PF12001.8 ETO00198.1 - 0.29 11.5 10.4 0.45 10.9 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) DUF4413 PF14372.6 ETO00198.1 - 6.2 7.3 10.4 3 8.3 1.6 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4413) CHIP_TPR_N PF18391.1 ETO00199.1 - 0.017 15.9 6.6 0.017 15.9 6.6 1.9 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain DUF3984 PF13136.6 ETO00199.1 - 0.27 10.6 2.4 0.3 10.5 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) DUF365 PF04033.12 ETO00199.1 - 0.31 11.3 5.7 0.5 10.7 5.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF365) MYO10_CC PF16735.5 ETO00199.1 - 3.5 7.8 12.9 2.5 8.3 3.0 2.4 1 1 1 2 2 2 0 Unconventional myosin-X coiled coil domain GTP_EFTU_D3 PF03143.17 ETO00202.1 - 0.00095 19.5 0.0 0.0024 18.1 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu C-terminal domain Actin PF00022.19 ETO00202.1 - 0.11 11.1 0.0 0.13 10.9 0.0 1.2 1 0 0 1 1 1 0 Actin HAD_SAK_2 PF18143.1 ETO00203.1 - 3.7e-10 40.3 0.0 8.2e-10 39.1 0.0 1.6 2 0 0 2 2 2 1 HAD domain in Swiss Army Knife RNA repair proteins Reticulon PF02453.17 ETO00204.1 - 0.14 12.1 6.4 0.026 14.5 2.6 1.6 2 0 0 2 2 2 0 Reticulon bZIP_2 PF07716.15 ETO00206.1 - 0.052 13.6 3.0 0.15 12.2 3.0 1.9 1 0 0 1 1 1 0 Basic region leucine zipper DPPIV_rep PF18811.1 ETO00206.1 - 0.18 11.8 0.3 0.18 11.8 0.3 3.0 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) low complexity region TSC22 PF01166.18 ETO00206.1 - 0.55 10.6 4.8 0.8 10.1 1.1 3.0 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF4365 PF14280.6 ETO00207.1 - 0.054 13.4 4.7 0.78 9.7 4.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4365) Astro_capsid_N PF03115.14 ETO00207.1 - 0.25 9.9 7.0 0.31 9.6 7.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF433 PF04255.14 ETO00208.1 - 0.046 13.6 0.1 0.22 11.4 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF433) DUF349 PF03993.12 ETO00208.1 - 0.077 13.3 0.6 0.12 12.7 0.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF349) HemY_N PF07219.13 ETO00209.1 - 0.036 14.3 0.1 0.38 11.0 0.1 2.2 2 0 0 2 2 2 0 HemY protein N-terminus Bap31 PF05529.12 ETO00209.1 - 0.097 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region DUF724 PF05266.14 ETO00210.1 - 0.095 12.5 4.9 0.11 12.4 4.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PDZ_2 PF13180.6 ETO00210.1 - 0.096 13.0 0.1 0.14 12.5 0.1 1.3 1 1 0 1 1 1 0 PDZ domain FERM_M PF00373.18 ETO00212.1 - 0.39 11.1 3.3 0.18 12.2 0.2 2.3 2 1 0 2 2 2 0 FERM central domain GREB1 PF15782.5 ETO00212.1 - 6.6 3.7 16.8 7 3.6 16.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer LVIVD PF08309.11 ETO00213.1 - 1.8 7.9 4.9 28 4.1 4.9 2.3 1 1 0 1 1 1 0 LVIVD repeat Yip1 PF04893.17 ETO00214.1 - 0.31 10.8 5.6 3.5 7.3 0.1 2.2 2 0 0 2 2 2 0 Yip1 domain Gly-zipper_Omp PF13488.6 ETO00214.1 - 2.8 8.0 15.5 13 5.9 10.7 3.0 2 1 0 2 2 2 0 Glycine zipper Pkinase PF00069.25 ETO00216.1 - 0.018 14.4 0.1 0.13 11.6 0.0 2.2 2 1 1 3 3 3 0 Protein kinase domain BTB PF00651.31 ETO00217.1 - 7e-08 32.7 0.0 2.4e-07 31.0 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain U-box PF04564.15 ETO00218.1 - 2.7e-10 40.3 0.0 7.4e-10 38.9 0.0 1.8 1 1 0 1 1 1 1 U-box domain CBS PF00571.28 ETO00219.1 - 0.0014 19.1 0.2 0.0069 16.8 0.2 2.0 1 1 0 1 1 1 1 CBS domain CdiI_2 PF18593.1 ETO00220.1 - 0.026 15.2 1.3 0.6 10.8 0.1 3.4 3 0 0 3 3 3 0 CdiI immunity protein Pex14_N PF04695.13 ETO00220.1 - 8.3 7.0 17.5 2.3 8.8 4.3 3.0 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FAM91_C PF14648.6 ETO00221.1 - 0.064 12.1 1.2 0.062 12.1 1.2 1.0 1 0 0 1 1 1 0 FAM91 C-terminus Connexin PF00029.19 ETO00221.1 - 0.11 12.2 4.9 0.13 12.0 4.9 1.0 1 0 0 1 1 1 0 Connexin CLN3 PF02487.17 ETO00221.1 - 0.31 10.1 1.8 0.31 10.0 1.8 1.0 1 0 0 1 1 1 0 CLN3 protein LRIF1 PF15741.5 ETO00221.1 - 0.78 8.2 9.3 0.88 8.0 9.3 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Folate_carrier PF01770.18 ETO00221.1 - 1 8.0 2.9 1.2 7.8 2.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier YqfQ PF14181.6 ETO00221.1 - 4.7 7.4 9.4 5.4 7.2 9.4 1.1 1 0 0 1 1 1 0 YqfQ-like protein Pkinase PF00069.25 ETO00222.1 - 9.1e-47 159.6 0.0 1.1e-46 159.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00222.1 - 4.2e-28 98.4 0.0 5.1e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO00222.1 - 9.4e-07 29.0 0.0 0.012 15.5 0.0 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ETO00222.1 - 7.1e-06 25.5 0.9 3.1e-05 23.4 0.9 1.9 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO00222.1 - 0.003 17.2 0.2 0.009 15.6 0.1 1.8 1 1 1 2 2 2 1 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ETO00222.1 - 0.0039 16.0 0.0 0.0075 15.1 0.0 1.4 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO00222.1 - 0.022 13.7 0.4 0.17 10.8 0.1 2.3 1 1 1 2 2 2 0 Haspin like kinase domain Peptidase_C14 PF00656.22 ETO00224.1 - 4.1e-09 36.7 0.3 4.2e-09 36.7 0.3 1.1 1 0 0 1 1 1 1 Caspase domain CUE PF02845.16 ETO00227.1 - 0.2 11.4 0.1 0.2 11.4 0.1 2.1 2 0 0 2 2 2 0 CUE domain PUB PF09409.10 ETO00227.1 - 0.38 10.7 3.7 0.48 10.4 1.1 2.6 2 2 0 2 2 2 0 PUB domain TPR_2 PF07719.17 ETO00229.1 - 8.2e-07 28.7 0.1 1.6 9.1 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO00229.1 - 1.3e-06 28.8 0.1 3.1e-06 27.6 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00229.1 - 4.8e-06 27.0 0.1 0.031 15.1 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00229.1 - 5.8e-05 23.5 0.2 1.7 9.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO00229.1 - 0.00032 20.0 0.1 0.00034 19.9 0.1 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO00229.1 - 0.00061 20.0 0.0 0.00067 19.8 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Coatomer_E PF04733.14 ETO00229.1 - 0.00076 19.0 0.0 0.00086 18.8 0.0 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_20 PF14561.6 ETO00229.1 - 0.0022 18.3 0.1 0.01 16.1 0.1 1.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETO00229.1 - 0.0027 17.5 0.0 0.0027 17.4 0.0 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain NARP1 PF12569.8 ETO00229.1 - 0.0037 16.3 0.0 0.0043 16.0 0.0 1.0 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_16 PF13432.6 ETO00229.1 - 0.0046 17.6 0.0 3.9 8.2 0.0 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00229.1 - 0.0066 16.2 0.1 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Cas_Cas02710 PF09670.10 ETO00229.1 - 0.017 13.9 0.0 0.02 13.7 0.0 1.0 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) HrpB1_HrpK PF09613.10 ETO00229.1 - 0.019 14.6 0.0 0.69 9.6 0.0 2.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) T6SS_VasJ PF16989.5 ETO00229.1 - 0.035 13.6 0.0 0.035 13.6 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion, EvfE, EvfF, ImpA, BimE, VC_A0119, VasJ Hydin_ADK PF17213.3 ETO00231.1 - 5 7.4 15.5 7.9 6.7 15.5 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain YL1 PF05764.13 ETO00231.1 - 6.7 6.7 29.3 8.8 6.4 29.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein WD40 PF00400.32 ETO00232.1 - 5.6e-09 36.5 3.7 7.7e-07 29.7 0.6 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO00232.1 - 0.0019 16.9 0.0 0.0022 16.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO00232.1 - 0.008 15.8 0.8 0.0089 15.6 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) ANAPC4_WD40 PF12894.7 ETO00232.1 - 0.036 14.4 0.0 0.05 13.9 0.0 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain UPF0449 PF15136.6 ETO00233.1 - 0.037 14.5 1.5 0.037 14.5 1.5 3.4 3 1 2 5 5 5 0 Uncharacterised protein family UPF0449 TraF_2 PF13729.6 ETO00233.1 - 0.08 12.3 4.3 0.075 12.4 2.8 1.8 1 1 0 1 1 1 0 F plasmid transfer operon, TraF, protein DUF2400 PF09674.10 ETO00233.1 - 0.45 10.5 9.5 7.5 6.5 9.5 2.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) PBP1_TM PF14812.6 ETO00235.1 - 9.6 6.7 10.0 7.8 6.9 3.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TMPIT PF07851.13 ETO00236.1 - 0.23 10.7 3.4 0.35 10.1 3.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein Neur_chan_memb PF02932.16 ETO00236.1 - 7.7 6.5 6.4 9.7 6.2 6.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pneumovirus_M2 PF06436.11 ETO00237.1 - 0.074 12.5 0.1 0.099 12.1 0.1 1.2 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) HEAT_2 PF13646.6 ETO00239.1 - 9e-06 26.0 0.0 0.43 11.0 0.0 4.0 3 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ETO00239.1 - 9.5e-05 22.3 4.2 12 6.4 0.0 5.9 6 0 0 6 6 6 0 HEAT repeat TAN PF11640.8 ETO00239.1 - 0.00025 21.2 6.5 0.14 12.3 0.3 3.6 1 1 1 3 3 3 2 Telomere-length maintenance and DNA damage repair HEAT_EZ PF13513.6 ETO00239.1 - 0.00028 21.3 0.0 6.7 7.3 0.0 3.9 4 0 0 4 4 4 2 HEAT-like repeat OrfB_IS605 PF01385.19 ETO00239.1 - 0.014 15.6 1.4 0.4 10.9 0.1 2.6 2 0 0 2 2 2 0 Probable transposase DUF2614 PF11023.8 ETO00239.1 - 0.037 14.1 0.9 9.3 6.4 0.1 3.2 3 0 0 3 3 3 0 Zinc-ribbon containing domain CLASP_N PF12348.8 ETO00239.1 - 0.048 13.2 10.4 0.043 13.4 2.5 3.2 3 1 0 3 3 3 0 CLASP N terminal AAA_lid_7 PF17867.1 ETO00239.1 - 0.067 13.4 5.7 6 7.1 0.2 3.9 2 2 2 4 4 4 0 Midasin AAA lid domain DUF1421 PF07223.11 ETO00239.1 - 0.08 12.8 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain (DUF1421) NLE PF08154.12 ETO00239.1 - 0.14 12.7 0.4 0.9 10.1 0.0 2.5 2 0 0 2 2 2 0 NLE (NUC135) domain RPAP3_C PF13877.6 ETO00239.1 - 0.21 12.2 4.6 33 5.1 0.0 4.4 2 1 3 5 5 5 0 Potential Monad-binding region of RPAP3 KicB PF03882.14 ETO00239.1 - 0.26 11.5 6.4 27 5.0 0.1 4.4 2 1 1 4 4 4 0 MukF winged-helix domain MecA_N PF05223.11 ETO00239.1 - 0.31 11.3 1.7 8.6 6.7 0.1 3.1 1 1 1 3 3 3 0 NTF2-like N-terminal transpeptidase domain DUF2555 PF10742.9 ETO00239.1 - 0.58 10.0 3.0 5 7.0 0.0 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2555) DUF2670 PF10875.8 ETO00239.1 - 1.3 9.1 4.1 2.8 8.0 0.4 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF2670) IPK PF03770.16 ETO00239.1 - 3.3 7.5 7.3 1.5 8.6 1.8 2.6 1 1 0 2 2 2 0 Inositol polyphosphate kinase H2TH PF06831.14 ETO00241.1 - 0.025 14.5 0.0 0.051 13.6 0.0 1.5 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase H2TH domain DUF4545 PF15078.6 ETO00241.1 - 0.026 13.5 0.1 0.033 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4545) Pkinase PF00069.25 ETO00243.1 - 5.9e-32 111.1 0.6 1.6e-30 106.4 0.0 2.6 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00243.1 - 8.7e-21 74.4 0.2 1.9e-14 53.6 0.2 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 ETO00243.1 - 0.069 12.5 2.1 0.13 11.6 2.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4354 PF14263.6 ETO00244.1 - 0.041 13.7 0.2 0.08 12.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4354) DIOX_N PF14226.6 ETO00245.1 - 5e-14 53.1 0.0 9.9e-14 52.1 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETO00245.1 - 9.7e-12 45.3 0.0 2e-11 44.3 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Homeodomain PF00046.29 ETO00245.1 - 0.064 13.1 0.0 0.16 11.8 0.0 1.6 1 0 0 1 1 1 0 Homeodomain ZapB PF06005.12 ETO00246.1 - 0.00045 20.6 2.9 0.00045 20.6 2.9 10.6 6 3 4 10 10 10 5 Cell division protein ZapB YcbB PF08664.10 ETO00247.1 - 0.2 11.7 1.9 0.22 11.5 0.1 1.9 2 0 0 2 2 2 0 YcbB domain PH PF00169.29 ETO00248.1 - 1.8e-12 47.7 0.6 1.8e-12 47.7 0.6 2.3 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ETO00248.1 - 1.2e-08 35.0 0.8 2.7e-08 33.9 0.8 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO00248.1 - 5.5e-08 33.0 1.7 7.1e-08 32.6 0.7 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 ETO00248.1 - 2.4e-06 27.9 10.9 6.2e-06 26.6 1.6 3.5 2 2 2 4 4 4 2 Pleckstrin homology domain PH_2 PF08458.10 ETO00248.1 - 0.067 13.6 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region DUF2222 PF09984.9 ETO00248.1 - 6.9 6.5 7.8 7.1 6.5 0.1 2.8 3 0 0 3 3 3 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) NAD_kinase PF01513.21 ETO00249.1 - 2.7e-55 187.7 0.0 6.4e-54 183.1 0.0 2.7 2 1 0 2 2 2 1 ATP-NAD kinase DAGK_cat PF00781.24 ETO00249.1 - 0.0027 17.3 0.0 0.005 16.4 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Piezo_RRas_bdg PF12166.8 ETO00250.1 - 0.058 12.7 1.1 0.066 12.5 1.1 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain FYDLN_acid PF09538.10 ETO00250.1 - 2.7 8.7 12.6 2.1 9.1 11.1 1.6 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 ETO00250.1 - 3.5 5.6 9.7 5 5.1 9.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 ETO00250.1 - 6.5 7.2 9.7 1.2 9.5 2.7 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ppx-GppA PF02541.16 ETO00251.1 - 0.11 11.9 4.7 3.4 7.0 0.0 2.7 3 0 0 3 3 3 0 Ppx/GppA phosphatase family WD40 PF00400.32 ETO00253.1 - 7.7e-06 26.6 1.0 7.7e-06 26.6 1.0 3.5 3 2 0 3 3 3 1 WD domain, G-beta repeat SWIM PF04434.17 ETO00253.1 - 0.065 12.9 1.9 0.076 12.7 0.5 1.8 2 0 0 2 2 2 0 SWIM zinc finger YoqO PF14037.6 ETO00254.1 - 0.029 14.9 3.9 0.045 14.3 4.0 1.5 1 1 0 1 1 1 0 YoqO-like protein HIP1_clath_bdg PF16515.5 ETO00256.1 - 0.0083 16.7 3.6 0.0083 16.7 3.6 2.2 2 0 0 2 2 2 1 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3896 PF13035.6 ETO00256.1 - 0.079 13.1 1.3 0.079 13.1 1.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) ABC_tran_CTD PF16326.5 ETO00256.1 - 0.12 12.6 12.6 0.22 11.8 3.1 2.3 2 0 0 2 2 2 0 ABC transporter C-terminal domain DUF2730 PF10805.8 ETO00256.1 - 0.56 10.3 5.0 12 6.1 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) APG6_N PF17675.1 ETO00256.1 - 1.6 9.2 18.0 1.6 9.2 4.5 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region Fungal_TACC PF12709.7 ETO00256.1 - 5.8 7.4 17.0 2.5 8.6 4.7 2.9 2 1 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins HALZ PF02183.18 ETO00256.1 - 8.3 6.7 9.8 0.26 11.6 0.9 2.7 3 0 0 3 3 3 0 Homeobox associated leucine zipper Kelch_6 PF13964.6 ETO00257.1 - 0.00093 19.4 1.9 3 8.3 0.1 4.4 5 1 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO00257.1 - 0.0015 18.4 1.1 1.3 9.1 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO00257.1 - 0.0033 17.0 0.6 0.035 13.7 0.1 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO00257.1 - 0.024 14.6 0.3 0.27 11.3 0.0 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00257.1 - 0.036 14.1 0.1 11 6.1 0.2 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO00257.1 - 0.078 13.3 0.0 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain RasGEF_N PF00618.20 ETO00258.1 - 7.8e-06 26.1 2.1 2.1e-05 24.7 1.3 1.8 1 1 1 2 2 2 1 RasGEF N-terminal motif WD40 PF00400.32 ETO00259.1 - 6.2e-06 26.9 7.5 0.0021 18.9 2.2 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO00259.1 - 0.0054 15.4 0.1 0.006 15.3 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00259.1 - 0.014 15.7 0.0 0.023 15.0 0.0 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO00261.1 - 5.4e-15 55.5 4.8 7.4e-07 29.8 1.4 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00261.1 - 6.9e-05 23.1 2.5 0.016 15.5 0.1 3.1 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain zf-C4H2 PF10146.9 ETO00261.1 - 0.0095 16.3 9.9 0.012 15.9 9.9 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein WD40_like PF17005.5 ETO00261.1 - 0.011 15.1 1.1 0.011 15.1 1.1 1.9 2 1 0 2 2 2 0 WD40-like domain BBS2_Mid PF14783.6 ETO00261.1 - 0.08 13.0 3.9 3.6 7.7 0.4 3.2 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region V_ATPase_I PF01496.19 ETO00261.1 - 0.095 10.6 10.9 0.1 10.5 10.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM76 PF16046.5 ETO00261.1 - 0.13 11.6 19.3 0.27 10.6 19.3 1.6 1 0 0 1 1 1 0 FAM76 protein Exonuc_VII_L PF02601.15 ETO00261.1 - 0.55 9.8 10.7 0.7 9.4 10.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MAD PF05557.13 ETO00261.1 - 1.1 7.5 25.1 1.4 7.2 25.1 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein DUF724 PF05266.14 ETO00261.1 - 1.8 8.3 19.5 1 9.1 17.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Atg14 PF10186.9 ETO00261.1 - 2.1 7.4 23.6 0.065 12.3 17.3 1.6 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Noelin-1 PF12308.8 ETO00261.1 - 4.3 7.4 9.8 0.94 9.5 5.5 2.2 2 1 1 3 3 3 0 Neurogenesis glycoprotein HMMR_N PF15905.5 ETO00261.1 - 5 6.5 28.9 7.8 5.9 28.9 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal ALMT PF11744.8 ETO00261.1 - 5.9 5.6 11.2 8.4 5.1 11.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Pkinase PF00069.25 ETO00262.1 - 1.4e-26 93.5 3.2 3e-20 72.7 0.1 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00262.1 - 2.8e-12 46.5 2.4 1.2e-10 41.2 0.2 2.0 1 1 1 2 2 2 2 Protein tyrosine kinase DUF1569 PF07606.11 ETO00262.1 - 0.057 13.4 0.5 0.086 12.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1569) Pkinase PF00069.25 ETO00264.1 - 1.8e-06 27.5 0.2 1.6e-05 24.5 0.2 2.0 1 1 0 1 1 1 1 Protein kinase domain PB1 PF00564.24 ETO00265.1 - 0.0057 16.6 0.7 0.012 15.5 0.7 1.6 1 0 0 1 1 1 1 PB1 domain Annexin PF00191.20 ETO00267.1 - 0.0007 19.6 0.0 0.001 19.1 0.0 1.4 1 0 0 1 1 1 1 Annexin DUF3807 PF12720.7 ETO00270.1 - 3.7 7.8 17.6 4 7.7 5.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) RNA_pol_RpbG PF16992.5 ETO00271.1 - 0.00026 21.1 0.0 0.0003 20.8 0.0 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase, subunit G HEAT PF02985.22 ETO00272.1 - 0.00022 21.2 0.1 0.045 14.0 0.0 3.3 4 0 0 4 4 4 1 HEAT repeat TAF6_C PF07571.13 ETO00272.1 - 0.099 13.0 0.0 4 7.8 0.0 2.2 1 1 1 2 2 2 0 TAF6 C-terminal HEAT repeat domain Cnd1 PF12717.7 ETO00272.1 - 0.16 12.0 2.4 2.6 8.0 0.0 2.2 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 SPATA48 PF15073.6 ETO00275.1 - 0.046 14.0 0.0 0.13 12.5 0.0 1.9 1 0 0 1 1 1 0 Spermatogenesis-associated protein 48 MAM33 PF02330.16 ETO00276.1 - 0.017 15.1 0.6 0.017 15.1 0.6 1.6 2 0 0 2 2 2 0 Mitochondrial glycoprotein DUF1320 PF07030.12 ETO00276.1 - 0.1 12.7 0.5 0.26 11.4 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1320) TFB6 PF17110.5 ETO00276.1 - 4.2 7.1 7.1 1.3 8.8 3.4 1.9 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH PT PF04886.12 ETO00277.1 - 1.7e-10 40.2 37.0 14 5.4 37.0 3.5 1 1 0 1 1 1 1 PT repeat Peripla_BP_4 PF13407.6 ETO00279.1 - 0.079 12.5 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein domain DUF859 PF05895.12 ETO00280.1 - 0.02 13.4 0.1 0.027 13.0 0.1 1.1 1 0 0 1 1 1 0 Siphovirus protein of unknown function (DUF859) PPP4R2 PF09184.11 ETO00281.1 - 0.39 10.3 14.4 0.45 10.1 14.4 1.0 1 0 0 1 1 1 0 PPP4R2 GRP PF07172.11 ETO00281.1 - 0.64 10.8 2.9 0.43 11.3 0.6 1.8 1 1 1 2 2 2 0 Glycine rich protein family BUD22 PF09073.10 ETO00281.1 - 6 6.1 14.6 6.9 5.9 14.6 1.0 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETO00281.1 - 7.8 4.7 8.9 7.7 4.7 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Tubulin PF00091.25 ETO00283.1 - 7.7e-46 156.8 6.6 1e-19 71.6 0.0 4.1 4 1 0 4 4 4 3 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO00283.1 - 1.6e-42 144.7 0.1 2.8e-42 143.9 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO00283.1 - 4.2e-05 23.8 0.0 7.8e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Lactonase PF10282.9 ETO00284.1 - 2.7e-15 56.5 0.0 3.9e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller WD40 PF00400.32 ETO00284.1 - 0.079 13.9 0.4 9.1 7.3 0.1 3.2 2 1 0 2 2 2 0 WD domain, G-beta repeat Ribosomal_L30_N PF08079.12 ETO00285.1 - 0.51 10.6 15.7 0.83 9.9 15.7 1.2 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain SR-25 PF10500.9 ETO00285.1 - 2.4 7.7 14.6 2.5 7.7 14.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpb1_7 PF04990.12 ETO00287.1 - 0.033 14.2 0.5 0.046 13.7 0.5 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 7 WD40 PF00400.32 ETO00288.1 - 1.5e-12 47.8 10.1 2.8e-05 24.8 2.2 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO00288.1 - 0.00056 18.7 0.5 0.4 9.3 0.1 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00288.1 - 0.015 15.5 0.5 11 6.3 0.1 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO00288.1 - 0.14 12.2 1.4 2.3 8.3 0.2 2.6 1 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO00289.1 - 6e-39 131.3 18.8 2.1e-06 28.4 2.6 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00289.1 - 1.6e-13 50.8 1.9 0.076 13.3 0.0 6.2 4 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00289.1 - 8.3e-10 37.9 8.7 0.0027 16.4 1.1 5.0 2 2 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00289.1 - 2.8e-09 36.7 9.6 0.0059 16.0 0.6 4.7 2 2 1 4 4 4 4 WD40-like domain LydB PF16084.5 ETO00289.1 - 0.049 13.5 0.0 0.13 12.1 0.0 1.8 1 0 0 1 1 1 0 LydA-holin antagonist GBP_C PF02841.14 ETO00291.1 - 0.025 14.0 6.9 0.029 13.8 6.9 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain PDDEXK_6 PF04720.12 ETO00291.1 - 1 9.3 8.4 1.2 9.0 8.4 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function TRAP_alpha PF03896.16 ETO00291.1 - 1.8 7.7 14.4 2.2 7.4 14.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO00291.1 - 6.2 4.8 29.2 6.4 4.7 29.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Mem_trans PF03547.18 ETO00291.1 - 8.1 4.7 6.3 10 4.4 6.3 1.1 1 0 0 1 1 1 0 Membrane transport protein CDC45 PF02724.14 ETO00291.1 - 8.3 4.6 19.1 9.2 4.4 19.1 1.0 1 0 0 1 1 1 0 CDC45-like protein RED_N PF07808.13 ETO00294.1 - 0.017 14.7 0.5 0.018 14.6 0.5 1.1 1 0 0 1 1 1 0 RED-like protein N-terminal region SirA PF10747.9 ETO00295.1 - 0.00048 20.5 3.3 0.057 13.8 0.5 3.1 2 1 1 3 3 3 2 Sporulation inhibitor of replication protein SirA Ank_2 PF12796.7 ETO00295.1 - 0.004 17.7 0.2 0.021 15.4 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO00295.1 - 0.054 14.1 0.1 0.15 12.7 0.1 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) NLRC4_HD2 PF17776.1 ETO00296.1 - 0.0038 17.8 0.2 0.0093 16.5 0.2 1.5 1 1 0 1 1 1 1 NLRC4 helical domain HD2 JHD PF17811.1 ETO00296.1 - 0.12 12.9 0.1 0.66 10.5 0.1 2.2 2 0 0 2 2 2 0 Jumonji helical domain UPF0242 PF06785.11 ETO00297.1 - 0.0032 17.6 45.0 0.033 14.3 28.5 2.5 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus Lebercilin PF15619.6 ETO00297.1 - 0.0039 16.9 19.8 0.0039 16.9 19.8 2.4 1 1 1 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF3584 PF12128.8 ETO00297.1 - 0.0071 13.9 28.5 0.0096 13.5 28.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Pro-rich_19 PF15455.6 ETO00297.1 - 0.0078 15.4 0.3 0.0078 15.4 0.3 1.5 2 0 0 2 2 2 1 Proline-rich 19 Fez1 PF06818.15 ETO00297.1 - 0.008 16.6 25.4 0.016 15.6 25.4 1.5 1 0 0 1 1 1 1 Fez1 FAM76 PF16046.5 ETO00297.1 - 0.097 12.0 30.7 0.029 13.7 12.3 2.3 1 1 1 2 2 2 0 FAM76 protein PilJ PF13675.6 ETO00297.1 - 0.21 11.6 6.4 0.094 12.7 1.8 2.2 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Golgin_A5 PF09787.9 ETO00297.1 - 0.42 10.0 35.3 0.77 9.2 35.1 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 ETO00297.1 - 0.64 10.0 35.8 0.67 10.0 6.3 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 V_ATPase_I PF01496.19 ETO00297.1 - 1 7.2 18.0 1.5 6.6 18.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.9 ETO00297.1 - 2.2 8.5 34.9 1.4 9.1 20.4 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 ETO00297.1 - 3.4 7.7 27.3 1.5 8.9 0.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO00297.1 - 4.4 7.8 36.1 0.062 13.8 23.0 3.0 1 1 2 3 3 2 0 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 ETO00297.1 - 6.2 7.5 34.4 1.5 9.5 15.5 3.2 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 ETO00297.1 - 9.1 6.4 32.2 7.1 6.8 8.1 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Dehalogenase PF13486.6 ETO00300.1 - 0.029 13.8 0.9 0.036 13.5 0.9 1.2 1 0 0 1 1 1 0 Reductive dehalogenase subunit MFS_Mycoplasma PF07672.13 ETO00300.1 - 0.043 13.1 0.6 0.068 12.4 0.6 1.3 1 0 0 1 1 1 0 Mycoplasma MFS transporter TPR_12 PF13424.6 ETO00302.1 - 6.5e-14 52.0 4.1 1.8e-09 37.7 0.6 1.9 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00302.1 - 2.6e-13 49.0 1.5 5.5e-06 26.0 0.3 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00302.1 - 7.6e-12 44.4 4.7 3.1e-07 30.0 1.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00302.1 - 1.2e-11 43.9 7.5 2.3e-06 27.2 2.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00302.1 - 3.7e-11 42.3 5.4 2.5e-07 30.4 1.6 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00302.1 - 1.2e-07 31.4 0.1 0.0011 18.8 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00302.1 - 7.2e-07 29.5 0.5 0.00017 22.0 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00302.1 - 9.7e-07 29.3 0.0 5.3e-05 23.8 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO00302.1 - 1.1e-05 25.3 9.7 0.37 10.8 0.1 3.7 3 1 0 3 3 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO00302.1 - 4.2e-05 23.7 1.0 0.023 14.9 0.1 3.4 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ETO00302.1 - 0.0001 22.4 0.2 0.25 11.8 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00302.1 - 0.00035 21.2 0.1 0.11 13.3 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat SNAP PF14938.6 ETO00302.1 - 0.02 14.4 0.1 0.025 14.0 0.1 1.1 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO00302.1 - 0.072 13.2 2.1 2.3 8.3 0.9 2.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Imm31 PF15591.6 ETO00302.1 - 0.09 12.6 0.0 1.5 8.7 0.1 2.5 3 0 0 3 3 3 0 Immunity protein 31 Sel1 PF08238.12 ETO00302.1 - 0.16 12.7 1.4 2.1 9.2 1.0 2.8 3 0 0 3 3 3 0 Sel1 repeat TPR_11 PF13414.6 ETO00302.1 - 0.16 11.6 10.6 0.19 11.5 1.5 4.1 3 2 2 5 5 5 0 TPR repeat Ubiq-assoc PF09145.10 ETO00302.1 - 0.88 9.6 6.1 6.1 6.9 0.2 2.8 3 0 0 3 3 3 0 Ubiquitin-associated Cellulase PF00150.18 ETO00303.1 - 0.019 14.4 0.1 0.025 14.0 0.1 1.1 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) PDR_CDR PF06422.12 ETO00304.1 - 0.0028 17.5 0.1 0.0041 17.0 0.1 1.2 1 0 0 1 1 1 1 CDR ABC transporter SseC PF04888.12 ETO00306.1 - 2.7 7.5 7.8 0.17 11.4 2.8 1.5 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family DUF4284 PF14112.6 ETO00307.1 - 0.0064 17.4 0.5 0.0086 17.0 0.5 1.3 1 0 0 1 1 1 1 Immunity protein 22 DUF1398 PF07166.11 ETO00307.1 - 0.4 10.7 3.8 0.58 10.2 2.8 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1398) CsoSCA PF08936.10 ETO00308.1 - 0.011 14.5 0.4 0.013 14.2 0.4 1.1 1 0 0 1 1 1 0 Carboxysome Shell Carbonic Anhydrase Fucose_iso_N1 PF07881.12 ETO00308.1 - 0.012 15.4 0.2 0.019 14.8 0.2 1.3 1 0 0 1 1 1 0 L-fucose isomerase, first N-terminal domain DUF2536 PF10750.9 ETO00308.1 - 0.79 9.7 6.1 0.16 11.9 1.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2536) KIP1 PF07765.12 ETO00308.1 - 1.1 9.4 5.6 8.4 6.6 0.3 2.8 2 2 0 2 2 2 0 KIP1-like protein Kelch_6 PF13964.6 ETO00309.1 - 2.1e-07 31.0 0.2 0.00054 20.1 0.2 2.6 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO00309.1 - 2.1e-05 24.0 0.5 6.9e-05 22.3 0.7 1.7 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO00309.1 - 0.00077 19.4 0.1 0.012 15.6 0.6 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO00309.1 - 0.0085 16.4 0.0 0.026 14.8 0.0 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain RAG2 PF03089.14 ETO00309.1 - 0.0099 14.9 0.0 0.013 14.5 0.0 1.2 1 0 0 1 1 1 1 Recombination activating protein 2 Kelch_4 PF13418.6 ETO00309.1 - 0.016 15.2 0.4 0.21 11.6 0.4 2.5 2 1 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO00309.1 - 0.055 13.5 0.5 0.12 12.4 0.5 1.6 1 0 0 1 1 1 0 Kelch motif NACHT PF05729.12 ETO00310.1 - 0.011 15.6 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 0 NACHT domain Syntaxin_2 PF14523.6 ETO00311.1 - 0.031 14.6 1.1 0.031 14.6 1.1 1.4 2 0 0 2 2 2 0 Syntaxin-like protein Syntaxin-18_N PF10496.9 ETO00311.1 - 0.25 11.6 2.1 0.48 10.7 2.0 1.7 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus LRR_4 PF12799.7 ETO00312.1 - 0.00089 19.6 2.9 0.047 14.1 0.7 2.1 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LMP PF04778.12 ETO00312.1 - 0.89 9.5 7.6 1.8 8.4 7.6 1.5 1 1 0 1 1 1 0 LMP repeated region ASXH PF13919.6 ETO00313.1 - 0.0094 16.0 0.8 0.012 15.7 0.8 1.3 1 0 0 1 1 1 1 Asx homology domain FAA_hydrolase_N PF09298.11 ETO00313.1 - 0.12 12.6 0.5 0.23 11.6 0.5 1.7 1 1 0 1 1 1 0 Fumarylacetoacetase N-terminal Kelch_6 PF13964.6 ETO00314.1 - 0.046 14.0 0.3 1.3 9.4 0.1 2.9 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO00315.1 - 3.4e-19 68.8 23.5 2.6e-05 24.9 0.1 6.6 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00315.1 - 6.4e-11 42.4 2.1 0.00041 20.6 0.0 5.6 2 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00315.1 - 7.1e-07 28.3 1.3 0.4 9.3 0.2 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Mitofilin PF09731.9 ETO00315.1 - 0.00022 20.2 30.9 0.00033 19.6 30.9 1.2 1 0 0 1 1 1 1 Mitochondrial inner membrane protein DUF2207 PF09972.9 ETO00315.1 - 0.012 14.5 4.8 0.034 12.9 4.8 1.7 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SLC12 PF03522.15 ETO00315.1 - 0.034 13.2 22.4 0.07 12.1 22.4 1.6 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO00315.1 - 0.66 8.2 37.5 0.98 7.6 37.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 ETO00315.1 - 3 5.8 27.8 4.5 5.3 27.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AF-4 PF05110.13 ETO00315.1 - 5.6 4.9 40.1 8.1 4.4 40.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein EMC3_TMCO1 PF01956.16 ETO00315.1 - 5.6 6.7 31.1 14 5.4 1.0 3.7 2 1 1 3 3 3 0 Integral membrane protein EMC3/TMCO1-like PAC3 PF10178.9 ETO00316.1 - 1e-16 60.9 0.0 2e-16 59.9 0.0 1.5 1 0 0 1 1 1 1 Proteasome assembly chaperone 3 DUF5586 PF17824.1 ETO00316.1 - 0.024 13.7 0.3 0.033 13.3 0.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5586) PalH PF08733.10 ETO00317.1 - 0.022 13.8 6.1 0.032 13.2 6.1 1.4 1 1 0 1 1 1 0 PalH/RIM21 Glyco_hydro38C2 PF17677.1 ETO00318.1 - 6.6e-12 45.4 0.0 9.4e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Glyco_hydro_38C PF07748.13 ETO00318.1 - 1.2e-11 45.1 0.0 2.6e-11 44.0 0.0 1.6 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain WD40 PF00400.32 ETO00319.1 - 2e-20 72.7 19.8 0.00016 22.3 0.4 6.7 5 2 0 5 5 5 5 WD domain, G-beta repeat WD40_like PF17005.5 ETO00319.1 - 3.5e-07 29.8 1.1 0.072 12.4 0.4 3.3 2 2 1 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 ETO00319.1 - 6.1e-07 29.7 0.4 0.91 9.9 0.0 4.7 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00319.1 - 1.2e-06 27.6 7.8 0.0013 17.4 0.7 3.4 1 1 2 4 4 4 2 Nucleoporin Nup120/160 RE_MamI PF09567.10 ETO00319.1 - 0.045 13.4 0.7 0.12 12.0 0.3 1.9 2 0 0 2 2 2 0 MamI restriction endonuclease GLTSCR1 PF15249.6 ETO00321.1 - 0.047 14.1 0.6 0.29 11.6 0.6 2.4 1 0 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein PCRF PF03462.18 ETO00321.1 - 3.7 7.4 6.0 0.66 9.8 0.8 2.3 2 0 0 2 2 2 0 PCRF domain GlutR_dimer PF00745.20 ETO00322.1 - 0.03 14.8 2.1 0.53 10.8 0.2 2.6 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain BAF PF02961.14 ETO00322.1 - 4 7.9 7.2 4 7.9 0.1 3.9 4 0 0 4 4 4 0 Barrier to autointegration factor Glutaredoxin2_C PF04399.13 ETO00323.1 - 0.049 13.5 0.1 0.049 13.5 0.1 1.9 2 1 0 2 2 2 0 Glutaredoxin 2, C terminal domain Lip_A_acyltrans PF03279.13 ETO00325.1 - 0.047 12.9 0.8 0.068 12.3 0.8 1.2 1 0 0 1 1 1 0 Bacterial lipid A biosynthesis acyltransferase Par3_HAL_N_term PF12053.8 ETO00325.1 - 0.13 12.5 0.1 1.1 9.5 0.1 2.2 2 0 0 2 2 2 0 N-terminal of Par3 and HAL proteins RabGAP-TBC PF00566.18 ETO00326.1 - 0.0025 17.5 0.0 0.0025 17.5 0.0 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Amidase PF01425.21 ETO00327.1 - 1e-26 93.9 0.9 3.2e-26 92.3 0.4 1.9 2 1 1 3 3 3 1 Amidase DUF588 PF04535.12 ETO00327.1 - 0.056 13.2 0.3 0.22 11.3 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF588) CENP-B_dimeris PF09026.10 ETO00328.1 - 9 6.8 8.5 2.2 8.7 0.4 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Acetyltransf_1 PF00583.25 ETO00331.1 - 1.6e-10 41.2 0.0 2.8e-10 40.5 0.0 1.4 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO00331.1 - 1.7e-06 28.0 0.0 6.4e-05 22.9 0.0 2.1 1 1 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO00331.1 - 6.2e-05 23.4 0.1 0.00015 22.1 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETO00331.1 - 0.00082 19.4 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain s48_45 PF07422.13 ETO00331.1 - 0.017 15.7 1.4 0.048 14.2 0.5 2.0 1 1 1 2 2 2 0 Sexual stage antigen s48/45 domain Acetyltransf_3 PF13302.7 ETO00331.1 - 0.034 14.8 0.0 0.14 12.9 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO00331.1 - 0.05 13.6 0.0 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_CG PF14542.6 ETO00331.1 - 0.055 13.6 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase DUF5613 PF18467.1 ETO00331.1 - 0.055 13.9 1.1 5.5 7.5 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5613) SET PF00856.28 ETO00332.1 - 0.0001 22.8 2.0 0.00093 19.6 0.3 2.7 2 1 0 2 2 2 1 SET domain Chromo PF00385.24 ETO00333.1 - 6.2e-06 26.0 0.3 1.7e-05 24.6 0.3 1.8 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DOCK_N PF16172.5 ETO00333.1 - 0.0019 17.2 0.4 0.46 9.4 0.0 2.1 2 0 0 2 2 2 2 DOCK N-terminus PHD PF00628.29 ETO00333.1 - 0.005 16.7 5.6 0.019 14.9 5.6 2.0 1 1 0 1 1 1 1 PHD-finger DUF4834 PF16118.5 ETO00333.1 - 2.7 9.0 7.2 4.9 8.2 7.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO00333.1 - 6.7 5.4 6.6 2.9 6.6 4.3 1.5 2 0 0 2 2 2 0 Presenilin NTP_transf_2 PF01909.23 ETO00334.1 - 0.046 14.0 1.0 0.1 12.9 0.2 2.0 2 0 0 2 2 2 0 Nucleotidyltransferase domain RabGGT_insert PF07711.11 ETO00334.1 - 0.056 13.9 0.7 0.2 12.2 0.1 2.1 2 1 1 3 3 3 0 Rab geranylgeranyl transferase alpha-subunit, insert domain Exo_endo_phos_2 PF14529.6 ETO00336.1 - 2.8e-05 24.0 0.8 2.8e-05 24.0 0.8 1.7 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase FERM_F1 PF18379.1 ETO00338.1 - 0.29 11.2 5.2 0.16 12.0 2.1 2.1 2 0 0 2 2 2 0 FERM F1 ubiquitin-like domain RabGAP-TBC PF00566.18 ETO00340.1 - 0.015 15.0 0.4 0.029 14.0 0.4 1.4 1 0 0 1 1 1 0 Rab-GTPase-TBC domain UCH PF00443.29 ETO00341.1 - 2.3e-13 50.2 0.0 5.7e-13 49.0 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO00341.1 - 6.5e-05 22.7 0.5 0.00017 21.3 0.5 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase YoqO PF14037.6 ETO00341.1 - 0.0027 18.2 2.6 0.009 16.5 2.6 1.8 1 0 0 1 1 1 1 YoqO-like protein Vma12 PF11712.8 ETO00341.1 - 0.044 13.9 0.8 0.1 12.7 0.0 1.9 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase HSP70 PF00012.20 ETO00342.1 - 2.3e-32 112.0 4.5 1.9e-20 72.6 0.1 2.1 1 1 1 2 2 2 2 Hsp70 protein HemY_N PF07219.13 ETO00343.1 - 0.18 12.0 0.7 0.25 11.5 0.7 1.4 1 1 0 1 1 1 0 HemY protein N-terminus DIOX_N PF14226.6 ETO00345.1 - 9.1e-08 32.9 0.0 1.5e-07 32.1 0.0 1.4 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal DUF4637 PF15470.6 ETO00347.1 - 2.3 7.9 11.2 0.27 11.0 2.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) FAM176 PF14851.6 ETO00347.1 - 8.3 6.1 15.4 7.8 6.1 8.5 2.2 2 0 0 2 2 2 0 FAM176 family DUF3464 PF11947.8 ETO00347.1 - 9.1 6.0 14.4 0.31 10.8 0.5 2.1 1 1 1 2 2 2 0 Photosynthesis affected mutant 68 TLD PF07534.16 ETO00348.1 - 9.2e-22 77.8 6.2 3.3e-21 76.0 0.9 2.2 2 0 0 2 2 2 2 TLD CCDC53 PF10152.9 ETO00349.1 - 4e-07 30.6 7.9 3.7e-06 27.4 0.2 2.9 3 0 0 3 3 3 2 Subunit CCDC53 of WASH complex PXT1 PF15214.6 ETO00349.1 - 1.5e-05 25.2 0.4 0.25 11.7 0.0 2.1 2 0 0 2 2 2 2 Peroxisomal testis-specific protein 1 Ribosomal_60s PF00428.19 ETO00349.1 - 0.0024 18.4 6.3 0.41 11.3 1.5 2.2 2 0 0 2 2 2 2 60s Acidic ribosomal protein DUF2974 PF11187.8 ETO00349.1 - 0.04 13.5 0.1 1.6 8.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) TonB_2 PF13103.6 ETO00349.1 - 0.078 13.2 0.6 1.7 8.9 0.1 2.2 2 0 0 2 2 2 0 TonB C terminal DUF2868 PF11067.8 ETO00349.1 - 0.28 10.7 4.6 3.5 7.1 0.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2868) Renin_r PF07850.14 ETO00349.1 - 0.29 11.8 7.4 3.7 8.2 1.1 2.2 2 0 0 2 2 2 0 Renin receptor-like protein ASFV_J13L PF05568.11 ETO00349.1 - 2.1 8.1 8.2 1.6 8.4 1.2 2.0 1 1 1 2 2 2 0 African swine fever virus J13L protein Kelch_4 PF13418.6 ETO00351.1 - 4.6e-08 33.0 2.3 0.0006 19.8 0.1 4.3 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO00351.1 - 1.2e-06 28.6 9.4 0.017 15.4 0.3 5.2 4 2 1 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO00351.1 - 1.5e-06 28.3 0.4 0.036 14.4 0.0 3.7 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO00351.1 - 2e-05 24.1 1.8 0.00036 20.1 0.4 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO00351.1 - 0.0014 18.6 1.4 0.37 10.9 0.3 3.6 4 0 0 4 4 4 1 Kelch motif DUF2415 PF10313.9 ETO00351.1 - 0.0045 16.9 0.0 0.086 12.8 0.0 2.4 2 0 0 2 2 2 1 Uncharacterised protein domain (DUF2415) Kelch_5 PF13854.6 ETO00351.1 - 0.009 16.0 7.7 3.7 7.7 0.0 4.5 5 1 0 5 5 5 2 Kelch motif aGPT-Pplase3 PF18746.1 ETO00351.1 - 0.047 13.0 2.3 3.7 6.8 0.2 2.2 2 0 0 2 2 2 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 PUB PF09409.10 ETO00352.1 - 0.059 13.3 2.4 0.11 12.5 1.6 2.0 1 1 0 1 1 1 0 PUB domain Cas9-BH PF16593.5 ETO00352.1 - 0.13 12.0 3.2 4.4 7.1 1.2 2.6 2 0 0 2 2 2 0 Bridge helix of CRISPR-associated endonuclease Cas9 DSPc PF00782.20 ETO00353.1 - 4.2e-26 91.3 1.5 1.1e-22 80.3 0.5 3.0 2 1 0 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ETO00353.1 - 7.1e-05 23.0 0.1 0.00014 22.0 0.1 1.6 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase PF00102.27 ETO00353.1 - 0.0021 17.7 0.2 0.0043 16.7 0.1 1.4 1 1 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETO00353.1 - 0.0062 16.8 0.2 0.011 16.0 0.2 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain GABP-alpha PF11620.8 ETO00354.1 - 0.24 11.6 3.6 0.16 12.2 0.7 2.2 2 0 0 2 2 2 0 GA-binding protein alpha chain CAP_GLY PF01302.25 ETO00356.1 - 3.8e-05 23.6 2.3 0.093 12.8 0.0 3.3 2 1 1 3 3 3 3 CAP-Gly domain ZZ PF00569.17 ETO00357.1 - 6.7e-14 51.4 6.7 1.8e-13 50.0 6.7 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type zf-B_box PF00643.24 ETO00357.1 - 0.0033 17.5 6.4 0.0091 16.1 6.4 1.8 1 0 0 1 1 1 1 B-box zinc finger C1_2 PF03107.16 ETO00357.1 - 0.0046 17.3 5.4 0.0046 17.3 5.4 2.1 2 0 0 2 2 2 1 C1 domain NRDD PF13597.6 ETO00357.1 - 0.22 10.3 3.0 0.28 9.9 3.0 1.1 1 0 0 1 1 1 0 Anaerobic ribonucleoside-triphosphate reductase TFIIA PF03153.13 ETO00358.1 - 0.00038 20.6 10.7 0.00052 20.1 10.7 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Spore_YhcN_YlaJ PF09580.10 ETO00358.1 - 0.0073 16.4 0.0 0.019 15.1 0.0 1.7 1 1 0 1 1 1 1 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) Pkinase PF00069.25 ETO00358.1 - 0.046 13.1 0.0 0.046 13.1 0.0 2.9 2 1 2 4 4 4 0 Protein kinase domain Dishevelled PF02377.15 ETO00358.1 - 7.8 6.9 9.4 15 6.0 9.4 1.5 1 1 0 1 1 1 0 Dishevelled specific domain Pkinase PF00069.25 ETO00359.1 - 7.3e-24 84.5 0.0 8.2e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00359.1 - 0.0032 16.8 0.1 0.0052 16.1 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase SID-1_RNA_chan PF13965.6 ETO00360.1 - 7.5 4.8 10.1 7.8 4.8 10.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 COMP PF11598.8 ETO00361.1 - 0.0068 16.8 0.0 0.011 16.2 0.0 1.3 1 0 0 1 1 1 1 Cartilage oligomeric matrix protein PH_5 PF15405.6 ETO00361.1 - 0.069 13.2 2.2 0.098 12.8 0.8 1.9 1 1 0 2 2 2 0 Pleckstrin homology domain TPR_12 PF13424.6 ETO00364.1 - 3e-25 88.3 1.0 6.4e-18 64.8 0.4 1.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00364.1 - 2.1e-18 65.6 0.2 3.4e-09 36.3 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00364.1 - 3.1e-14 52.1 9.0 4.6e-09 35.7 4.6 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00364.1 - 2.1e-13 49.3 0.1 9.1e-08 31.6 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00364.1 - 6.8e-09 35.3 8.3 3.5e-06 26.8 2.7 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00364.1 - 2.5e-08 33.4 5.6 2e-05 24.4 2.3 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00364.1 - 0.00018 21.6 0.2 0.023 15.1 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO00364.1 - 0.0027 17.5 0.3 0.014 15.2 0.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF5113) Fis1_TPR_C PF14853.6 ETO00364.1 - 0.0033 17.5 3.0 0.051 13.6 0.7 2.1 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat HTH_Bact PF18768.1 ETO00364.1 - 0.0069 15.9 0.7 0.76 9.4 0.0 3.4 3 1 1 4 4 4 1 Helix-turn-helix bacterial domain TPR_11 PF13414.6 ETO00364.1 - 0.01 15.5 8.6 0.13 12.0 0.3 3.4 2 2 2 4 4 4 0 TPR repeat TPR_6 PF13174.6 ETO00364.1 - 0.01 16.4 0.1 2.3 9.0 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00364.1 - 0.032 14.9 0.0 3.1 8.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 ETO00364.1 - 0.037 14.3 0.2 2.7 8.4 0.1 2.4 2 0 0 2 2 2 0 PPR repeat TPR_14 PF13428.6 ETO00364.1 - 0.081 13.8 0.0 17 6.5 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF962 PF06127.11 ETO00364.1 - 0.23 11.6 1.5 0.37 10.9 0.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF962) Arm PF00514.23 ETO00365.1 - 1.4e-13 50.4 7.4 0.0007 19.5 0.0 6.5 7 1 0 7 7 7 3 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETO00365.1 - 0.01 16.2 0.1 1.1 9.6 0.0 3.2 2 1 1 3 3 3 0 HEAT repeats RICTOR_V PF14668.6 ETO00365.1 - 0.033 14.4 4.0 0.15 12.4 0.2 3.7 4 1 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 TetR_C_8 PF14278.6 ETO00365.1 - 0.041 14.0 1.9 0.67 10.1 0.0 3.4 3 1 1 4 4 4 0 Transcriptional regulator C-terminal region HEAT PF02985.22 ETO00365.1 - 0.056 13.7 0.0 26 5.4 0.0 4.2 4 0 0 4 4 4 0 HEAT repeat Rtt106_N PF18215.1 ETO00365.1 - 0.09 12.5 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain HEAT_EZ PF13513.6 ETO00365.1 - 0.19 12.3 0.3 16 6.1 0.0 3.8 4 1 2 6 6 6 0 HEAT-like repeat TPR_12 PF13424.6 ETO00367.1 - 2.5e-34 117.4 3.0 1.9e-14 53.7 0.5 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00367.1 - 1.4e-29 100.6 23.3 3e-10 39.5 3.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00367.1 - 7.3e-29 98.8 0.2 2.5e-12 46.2 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00367.1 - 2e-26 89.9 15.0 6.1e-08 32.2 2.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00367.1 - 2.3e-24 83.6 2.4 4e-08 32.7 0.1 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00367.1 - 8.8e-24 81.7 19.0 1.2e-08 34.5 1.6 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00367.1 - 5.6e-14 51.7 0.0 0.006 17.3 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00367.1 - 9.5e-12 44.4 23.0 0.002 17.8 0.8 5.2 2 2 2 4 4 4 3 TPR repeat TPR_6 PF13174.6 ETO00367.1 - 1.3e-10 41.2 4.9 0.015 15.9 0.2 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00367.1 - 8.4e-10 39.1 0.0 0.0073 16.9 0.3 3.9 2 2 2 4 4 4 4 Tetratricopeptide repeat SNAP PF14938.6 ETO00367.1 - 1.1e-09 38.1 6.5 2.8e-09 36.8 1.6 2.0 1 1 1 2 2 2 1 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO00367.1 - 1.4e-09 37.9 12.1 0.0019 18.2 0.1 4.1 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO00367.1 - 9.8e-08 31.9 11.2 7.5e-05 22.8 0.8 4.7 4 2 0 4 4 4 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO00367.1 - 4.8e-07 29.1 3.7 0.18 11.3 0.1 3.6 3 0 0 3 3 3 3 SHNi-TPR DUF2225 PF09986.9 ETO00367.1 - 1.1e-05 25.2 12.4 0.00024 20.9 6.1 3.1 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) DUF2262 PF10020.9 ETO00367.1 - 0.00011 22.7 4.2 0.067 13.6 0.1 2.3 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2262) Sel1 PF08238.12 ETO00367.1 - 0.00018 22.1 10.4 1 10.1 0.9 4.1 4 1 0 4 4 3 2 Sel1 repeat ANAPC3 PF12895.7 ETO00367.1 - 0.00025 21.2 11.0 0.035 14.3 0.9 3.1 2 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO00367.1 - 0.00026 21.4 4.2 0.16 12.5 0.3 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO00367.1 - 0.0014 18.1 0.0 0.88 8.9 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region PPR PF01535.20 ETO00367.1 - 0.0034 17.5 4.7 7.2 7.1 0.3 4.2 4 0 0 4 4 4 0 PPR repeat TPR_3 PF07720.12 ETO00367.1 - 0.0038 17.2 12.4 0.2 11.7 1.3 3.8 5 0 0 5 5 5 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO00367.1 - 0.0047 16.7 7.2 0.33 10.7 0.5 3.4 3 1 0 4 4 4 1 Domain of unknown function (DUF5113) TPR_9 PF13371.6 ETO00367.1 - 0.0086 16.2 0.0 3.4 7.9 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat RPN7 PF10602.9 ETO00367.1 - 0.015 15.0 8.9 1.4 8.6 1.4 3.2 2 2 1 3 3 3 0 26S proteasome subunit RPN7 OEP PF02321.18 ETO00367.1 - 0.033 14.0 1.8 6.4 6.5 0.3 2.4 2 1 0 2 2 2 0 Outer membrane efflux protein Miga PF10265.9 ETO00367.1 - 0.04 12.9 0.1 0.69 8.8 0.0 2.0 2 0 0 2 2 2 0 Mitoguardin DUF3856 PF12968.7 ETO00367.1 - 0.052 13.6 1.5 0.2 11.8 0.4 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) NSF PF02071.20 ETO00367.1 - 0.054 14.2 13.6 15 6.9 0.1 5.0 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TetR_C_19 PF17924.1 ETO00367.1 - 0.078 13.6 3.3 2.7 8.6 0.2 3.1 4 0 0 4 4 3 0 Tetracyclin repressor-like, C-terminal domain Goodbye PF17109.5 ETO00367.1 - 0.11 12.9 0.3 0.37 11.2 0.0 1.9 3 0 0 3 3 2 0 fungal STAND N-terminal Goodbye domain ATP-synt_E_2 PF08112.11 ETO00367.1 - 0.11 12.8 2.6 9.2 6.6 0.2 3.1 3 0 0 3 3 3 0 ATP synthase epsilon subunit pPIWI_RE_Z PF18155.1 ETO00367.1 - 0.12 12.3 0.4 4.4 7.1 0.1 2.3 2 0 0 2 2 2 0 pPIWI RE three-gene island domain Z HTH_Bact PF18768.1 ETO00367.1 - 0.12 11.9 5.4 8.6 6.0 0.1 3.3 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain NYD-SP28_assoc PF14775.6 ETO00367.1 - 0.15 12.2 3.4 3 8.0 0.1 3.2 3 0 0 3 3 3 0 Sperm tail C-terminal domain TPR_5 PF12688.7 ETO00367.1 - 0.16 12.2 0.7 12 6.2 0.0 2.9 1 1 2 3 3 3 0 Tetratrico peptide repeat TPR_21 PF09976.9 ETO00367.1 - 0.49 10.1 5.2 1.1 9.0 0.6 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain Styelin PF17562.2 ETO00367.1 - 0.61 10.5 3.1 2.5 8.5 0.1 3.1 3 1 0 3 3 3 0 Styelin SPO22 PF08631.10 ETO00367.1 - 1.3 8.4 8.8 20 4.6 0.8 3.2 1 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like UVR PF02151.19 ETO00367.1 - 1.8 8.4 7.0 18 5.3 0.1 3.9 3 1 1 4 4 4 0 UvrB/uvrC motif 14-3-3 PF00244.20 ETO00367.1 - 2.2 7.7 10.4 2.4 7.6 0.2 3.4 2 2 1 4 4 4 0 14-3-3 protein Clathrin PF00637.20 ETO00367.1 - 2.8 7.8 8.5 9.5 6.1 0.6 3.0 2 1 0 3 3 2 0 Region in Clathrin and VPS OST-HTH PF12872.7 ETO00369.1 - 0.034 14.0 0.0 0.05 13.4 0.0 1.3 1 0 0 1 1 1 0 OST-HTH/LOTUS domain POX PF07526.11 ETO00369.1 - 0.067 13.8 2.6 5.8 7.5 0.0 2.2 2 0 0 2 2 2 0 Associated with HOX Menin PF05053.13 ETO00369.1 - 4.7 5.4 9.5 6.6 5.0 9.5 1.2 1 0 0 1 1 1 0 Menin Kelch_2 PF07646.15 ETO00370.1 - 1.3e-05 24.9 0.3 0.027 14.4 0.3 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO00370.1 - 1.3e-05 25.0 0.1 0.018 15.0 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO00370.1 - 0.0002 21.5 0.6 0.15 12.4 0.4 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO00370.1 - 0.0078 16.5 0.0 0.082 13.2 0.0 2.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO00370.1 - 0.012 15.2 0.5 0.024 14.2 0.1 1.7 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO00370.1 - 0.13 12.3 0.9 0.38 10.8 0.8 1.8 2 0 0 2 2 2 0 Kelch motif Radial_spoke PF04712.12 ETO00371.1 - 0.0004 19.5 7.0 0.00041 19.4 7.0 1.0 1 0 0 1 1 1 1 Radial spokehead-like protein DNA_pol_phi PF04931.13 ETO00371.1 - 0.00074 17.8 5.9 0.00074 17.8 5.9 1.1 1 0 0 1 1 1 1 DNA polymerase phi FAM176 PF14851.6 ETO00371.1 - 0.00083 19.0 0.5 0.00098 18.8 0.5 1.2 1 0 0 1 1 1 1 FAM176 family CENP-B_dimeris PF09026.10 ETO00371.1 - 0.0028 18.0 7.6 0.0039 17.5 7.6 1.3 1 0 0 1 1 1 1 Centromere protein B dimerisation domain CbtA PF09490.10 ETO00371.1 - 0.0076 16.0 0.2 0.0094 15.7 0.2 1.2 1 0 0 1 1 1 1 Probable cobalt transporter subunit (CbtA) TRAP_alpha PF03896.16 ETO00371.1 - 0.0086 15.3 1.8 0.011 15.0 1.8 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF3591 PF12157.8 ETO00371.1 - 0.011 14.4 0.5 0.013 14.2 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3591) OAD_gamma PF04277.13 ETO00371.1 - 0.013 16.1 0.2 0.013 16.1 0.2 1.4 2 0 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain SDA1 PF05285.12 ETO00371.1 - 0.024 14.1 6.9 0.023 14.1 6.9 1.1 1 0 0 1 1 1 0 SDA1 BSP_II PF05432.11 ETO00371.1 - 0.061 13.0 13.6 0.07 12.8 13.6 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) WRNPLPNID PF15017.6 ETO00371.1 - 0.063 14.2 14.5 0.13 13.2 11.0 2.1 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box CobT PF06213.12 ETO00371.1 - 0.071 12.5 8.0 0.089 12.2 8.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BUD22 PF09073.10 ETO00371.1 - 0.071 12.4 4.4 0.073 12.4 4.4 1.0 1 0 0 1 1 1 0 BUD22 Tim54 PF11711.8 ETO00371.1 - 0.088 11.6 2.3 0.099 11.4 2.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sigma70_ner PF04546.13 ETO00371.1 - 0.094 12.6 9.3 0.13 12.1 9.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Conotoxin PF02950.17 ETO00371.1 - 0.095 13.7 0.1 0.16 13.0 0.1 1.3 1 0 0 1 1 1 0 Conotoxin TFB6 PF17110.5 ETO00371.1 - 0.11 12.2 0.7 0.11 12.2 0.7 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Tmemb_9 PF05434.11 ETO00371.1 - 0.2 11.5 0.0 0.25 11.2 0.0 1.1 1 0 0 1 1 1 0 TMEM9 PI3K_1B_p101 PF10486.9 ETO00371.1 - 0.24 9.1 1.6 0.25 9.1 1.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1840 PF08895.11 ETO00371.1 - 0.24 11.7 2.9 0.37 11.1 2.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Phage_Gp23 PF10669.9 ETO00371.1 - 0.3 11.4 3.7 0.44 10.9 3.7 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Med17 PF10156.9 ETO00371.1 - 0.36 9.5 3.9 0.39 9.4 3.9 1.0 1 0 0 1 1 1 0 Subunit 17 of Mediator complex SHR3_chaperone PF08229.11 ETO00371.1 - 0.47 9.4 2.1 0.63 9.0 1.8 1.4 2 0 0 2 2 2 0 ER membrane protein SH3 RPN2_C PF18004.1 ETO00371.1 - 0.56 10.1 8.1 0.74 9.7 8.1 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain MRNIP PF15749.5 ETO00371.1 - 0.63 10.8 4.8 0.86 10.3 4.8 1.1 1 0 0 1 1 1 0 MRN-interacting protein GREB1 PF15782.5 ETO00371.1 - 1.2 6.2 2.3 1.3 6.0 2.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RRN3 PF05327.11 ETO00371.1 - 1.6 7.2 3.6 1.5 7.3 3.6 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Trypan_PARP PF05887.11 ETO00371.1 - 2.4 8.1 15.1 3.4 7.6 15.1 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nop53 PF07767.11 ETO00371.1 - 2.7 7.3 12.9 3.2 7.0 12.9 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF4746 PF15928.5 ETO00371.1 - 4.8 6.5 15.0 6.2 6.2 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GCR1_C PF12550.8 ETO00372.1 - 0.027 14.8 3.6 0.032 14.5 3.6 1.1 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes HSP70 PF00012.20 ETO00373.1 - 1.9e-08 33.0 0.2 0.0007 17.9 0.2 2.4 2 1 0 2 2 2 2 Hsp70 protein Peptidase_S13 PF02113.15 ETO00374.1 - 0.14 10.8 0.0 0.17 10.6 0.0 1.1 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family WD40 PF00400.32 ETO00375.1 - 0.29 12.1 5.0 0.76 10.8 1.2 3.1 2 1 1 3 3 3 0 WD domain, G-beta repeat GreA_GreB_N PF03449.15 ETO00376.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.6 1 0 0 1 1 1 1 Transcription elongation factor, N-terminal SPACA9 PF15120.6 ETO00376.1 - 0.0084 15.9 0.0 0.019 14.8 0.0 1.5 1 0 0 1 1 1 1 Sperm acrosome-associated protein 9 ORC_WH_C PF18137.1 ETO00376.1 - 0.055 13.5 0.1 0.35 10.9 0.0 2.3 2 1 1 3 3 3 0 Origin recognition complex winged helix C-terminal DnaB_2 PF07261.11 ETO00376.1 - 0.074 12.8 0.3 0.23 11.2 0.3 1.8 1 0 0 1 1 1 0 Replication initiation and membrane attachment WD40 PF00400.32 ETO00377.1 - 9.5e-29 99.1 28.0 2.4e-07 31.3 0.4 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00377.1 - 1.2e-07 31.9 0.4 0.048 14.0 0.0 3.9 3 2 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00377.1 - 0.00011 21.1 0.4 3 6.4 0.0 3.9 3 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00377.1 - 0.0085 15.4 4.0 0.76 9.0 0.2 3.8 1 1 3 4 4 4 1 WD40-like domain NLRC4_HD2 PF17776.1 ETO00378.1 - 0.00035 21.1 0.2 0.011 16.3 0.0 2.6 2 0 0 2 2 2 1 NLRC4 helical domain HD2 TPR_19 PF14559.6 ETO00378.1 - 0.013 16.0 0.3 5.9 7.5 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat Orf78 PF06024.12 ETO00379.1 - 0.02 15.2 0.1 0.023 15.0 0.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) P5-ATPase PF12409.8 ETO00379.1 - 0.13 12.3 0.2 0.16 12.0 0.2 1.0 1 0 0 1 1 1 0 P5-type ATPase cation transporter TPH PF13868.6 ETO00380.1 - 3.5e-05 22.5 41.5 3.5e-05 22.5 41.5 1.8 2 0 0 2 2 2 1 Trichohyalin-plectin-homology domain Tox-HNH-HHH PF15637.6 ETO00380.1 - 1.2 9.4 5.2 0.35 11.0 0.8 2.4 1 1 1 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif EzrA PF06160.12 ETO00381.1 - 0.003 15.8 14.0 0.0038 15.5 14.0 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA MPS2 PF17060.5 ETO00381.1 - 0.026 13.8 14.8 0.033 13.5 14.8 1.0 1 0 0 1 1 1 0 Monopolar spindle protein 2 IL11 PF07400.11 ETO00381.1 - 0.047 13.3 0.4 0.047 13.3 0.4 1.6 1 1 1 2 2 2 0 Interleukin 11 XhlA PF10779.9 ETO00381.1 - 0.074 13.3 1.6 0.074 13.3 1.6 2.4 2 1 0 3 3 3 0 Haemolysin XhlA JIP_LZII PF16471.5 ETO00381.1 - 0.36 11.0 9.6 2.1 8.6 2.8 2.7 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II MFA1_2 PF17317.2 ETO00381.1 - 0.42 10.4 1.8 6.5 6.6 0.1 2.8 2 0 0 2 2 2 0 Mating hormone A-factor 1&2 V_ATPase_I PF01496.19 ETO00381.1 - 0.77 7.6 12.4 0.88 7.4 12.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 ETO00381.1 - 1.3 8.5 11.1 1.5 8.3 11.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Spc7 PF08317.11 ETO00381.1 - 1.4 7.7 18.7 2.4 7.0 18.7 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein G-gamma PF00631.22 ETO00381.1 - 1.8 8.7 5.5 3.9 7.5 1.0 2.5 2 0 0 2 2 2 0 GGL domain DUF4407 PF14362.6 ETO00381.1 - 1.8 7.8 13.9 2.2 7.6 13.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Goodbye PF17109.5 ETO00381.1 - 2.1 8.8 5.3 1.2 9.6 2.5 2.0 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain Fib_alpha PF08702.10 ETO00381.1 - 3.4 7.9 13.0 3.3 7.9 4.8 2.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 ETO00381.1 - 3.8 7.6 8.9 2.2 8.4 3.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PspB PF06667.12 ETO00381.1 - 5.2 7.2 7.7 0.96 9.6 2.7 2.2 2 1 0 2 2 2 0 Phage shock protein B RRP36 PF06102.12 ETO00383.1 - 3.3e-10 40.2 29.1 4.4e-09 36.5 29.1 1.9 1 1 0 1 1 1 1 rRNA biogenesis protein RRP36 WD40 PF00400.32 ETO00384.1 - 2e-60 199.3 9.4 3.8e-11 43.3 0.0 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00384.1 - 1.8e-23 82.6 0.6 8e-07 29.3 0.0 5.9 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO00384.1 - 3.4e-13 49.6 0.8 5.8e-05 22.6 0.0 3.2 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO00384.1 - 1.8e-09 37.1 0.0 0.34 9.8 0.0 5.2 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO00384.1 - 4.4e-08 32.2 2.2 0.22 10.1 0.1 4.8 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO00384.1 - 1.6e-06 27.9 0.5 1.4 8.9 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO00384.1 - 0.00063 18.4 0.3 0.61 8.6 0.1 2.6 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO00384.1 - 0.001 17.9 5.7 1.3 7.7 0.4 4.1 1 1 3 4 4 4 2 Nup133 N terminal like nos_propeller PF18764.1 ETO00384.1 - 0.0018 18.1 0.0 0.87 9.5 0.0 3.7 4 0 0 4 4 4 1 Nitrous oxide reductase propeller repeat DPPIV_N PF00930.21 ETO00384.1 - 0.0053 15.6 0.3 5.8 5.6 0.0 3.6 1 1 2 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO00384.1 - 0.0059 16.7 0.1 5.2 7.2 0.0 4.4 3 2 3 6 6 6 1 Family of unknown function (DUF5570) DUF5046 PF16465.5 ETO00384.1 - 0.048 13.1 0.2 3.2 7.1 0.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) HPS6 PF15702.5 ETO00384.1 - 0.098 10.6 0.0 3.5 5.5 0.0 2.5 1 1 0 2 2 2 0 Hermansky-Pudlak syndrome 6 protein Proteasome_A_N PF10584.9 ETO00384.1 - 0.27 10.9 1.6 62 3.4 0.1 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO00387.1 - 2.4e-25 88.3 5.4 3.9e-06 27.5 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00387.1 - 3e-06 27.4 0.2 0.0056 16.9 0.0 2.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00387.1 - 0.00049 18.9 2.8 0.11 11.1 0.4 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO00387.1 - 0.0045 15.8 2.2 0.83 8.3 0.4 2.7 1 1 2 3 3 3 3 Nup133 N terminal like Ge1_WD40 PF16529.5 ETO00387.1 - 0.034 13.1 0.1 0.83 8.6 0.0 2.4 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO00387.1 - 0.084 12.7 0.1 0.14 12.0 0.1 1.4 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A NMT1_3 PF16868.5 ETO00388.1 - 6.6e-33 114.4 0.0 1.1e-32 113.7 0.0 1.3 1 0 0 1 1 1 1 NMT1-like family CSG2 PF16965.5 ETO00390.1 - 0.015 14.3 1.5 0.019 13.9 1.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Secretin_N_2 PF07655.13 ETO00390.1 - 0.059 13.9 5.8 0.12 12.9 5.8 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain CENP-B_dimeris PF09026.10 ETO00390.1 - 0.32 11.4 3.6 1 9.8 3.1 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Methyltransf_12 PF08242.12 ETO00390.1 - 1.3 9.8 8.9 3.7 8.4 0.0 2.2 1 1 0 2 2 2 0 Methyltransferase domain RR_TM4-6 PF06459.12 ETO00393.1 - 0.0043 16.9 19.8 0.0049 16.8 19.8 1.2 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO00393.1 - 0.022 13.5 17.5 0.03 13.1 17.5 1.1 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 ETO00393.1 - 0.075 13.2 22.7 0.12 12.5 22.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) VIR_N PF15912.5 ETO00393.1 - 0.14 11.8 14.7 0.18 11.4 14.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF4746 PF15928.5 ETO00393.1 - 0.16 11.3 17.3 0.19 11.1 17.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.15 ETO00393.1 - 0.18 10.8 16.9 0.2 10.7 16.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Vfa1 PF08432.10 ETO00393.1 - 0.19 12.1 30.7 0.3 11.4 30.7 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 COesterase PF00135.28 ETO00393.1 - 0.3 9.9 5.4 0.31 9.8 5.4 1.0 1 0 0 1 1 1 0 Carboxylesterase family GAGA_bind PF06217.12 ETO00393.1 - 0.34 11.2 16.3 0.42 10.9 16.3 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.17 ETO00393.1 - 0.36 11.0 10.1 0.47 10.6 10.1 1.4 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 ETO00393.1 - 0.74 8.0 24.8 0.92 7.7 24.8 1.1 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.16 ETO00393.1 - 0.75 9.1 30.3 1.2 8.5 30.3 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 TRAP_alpha PF03896.16 ETO00393.1 - 1 8.5 9.8 1.4 8.1 9.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SpoIIP PF07454.11 ETO00393.1 - 1.3 8.4 20.9 1.9 7.9 20.9 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PPL5 PF18168.1 ETO00393.1 - 1.7 7.9 16.2 2.4 7.4 16.2 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Zip PF02535.22 ETO00393.1 - 1.8 7.7 11.5 2.2 7.4 11.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FancD2 PF14631.6 ETO00393.1 - 2.3 5.5 18.1 2.7 5.3 18.1 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RP-C_C PF11800.8 ETO00393.1 - 3.2 7.8 9.6 4.8 7.2 9.6 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region CSG2 PF16965.5 ETO00393.1 - 3.3 6.6 8.3 3.7 6.4 8.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator RPN2_C PF18004.1 ETO00393.1 - 3.9 7.4 32.8 7.4 6.5 32.8 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SID-1_RNA_chan PF13965.6 ETO00393.1 - 5 5.4 9.0 5.3 5.3 9.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 ETO00393.1 - 7 6.6 11.2 8.2 6.4 11.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MCM_bind PF09739.9 ETO00393.1 - 7.8 4.8 20.9 9.5 4.5 20.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Hid1 PF12722.7 ETO00393.1 - 8 4.5 15.4 8.7 4.3 15.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SprA-related PF12118.8 ETO00393.1 - 9.2 5.3 19.4 12 4.9 19.4 1.2 1 0 0 1 1 1 0 SprA-related family Myotub-related PF06602.14 ETO00394.1 - 3.2e-56 190.8 1.4 3.6e-56 190.6 1.4 1.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain HSP90 PF00183.18 ETO00396.1 - 1.8e-31 109.7 0.1 2.3e-31 109.3 0.1 1.0 1 0 0 1 1 1 1 Hsp90 protein Methyltr_RsmB-F PF01189.17 ETO00396.1 - 0.0012 18.5 0.0 0.0013 18.5 0.0 1.2 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Cofac_haem_bdg PF04187.13 ETO00396.1 - 0.062 13.3 0.0 0.072 13.1 0.0 1.2 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN DUF2951 PF11166.8 ETO00397.1 - 0.062 13.5 1.3 0.062 13.5 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DEAD_assoc PF08494.11 ETO00398.1 - 0.2 11.4 0.0 0.29 10.9 0.0 1.2 1 0 0 1 1 1 0 DEAD/H associated Mid1 PF12929.7 ETO00399.1 - 0.029 13.6 0.8 0.035 13.3 0.8 1.1 1 0 0 1 1 1 0 Stretch-activated Ca2+-permeable channel component RNA_pol_Rpb1_5 PF04998.17 ETO00399.1 - 0.27 10.6 2.9 0.32 10.4 2.9 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Nop14 PF04147.12 ETO00400.1 - 4.7 5.3 14.1 5.8 5.0 14.1 1.1 1 0 0 1 1 1 0 Nop14-like family RPN2_C PF18004.1 ETO00400.1 - 7.7 6.4 10.8 0.68 9.8 2.3 2.1 1 1 1 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF3098 PF11297.8 ETO00402.1 - 0.07 12.7 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3098) OTCace PF00185.24 ETO00402.1 - 0.11 12.5 0.2 0.67 10.0 0.1 1.8 1 1 1 2 2 2 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain GTP_EFTU_D3 PF03143.17 ETO00403.1 - 8.7e-14 51.8 0.2 1.9e-12 47.4 0.0 2.7 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETO00403.1 - 2.1e-07 31.2 0.1 6.9e-07 29.6 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ETO00403.1 - 5e-06 26.3 0.0 1.2e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Pro_isomerase PF00160.21 ETO00404.1 - 2.6e-44 151.3 0.1 3.1e-44 151.0 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PUB PF09409.10 ETO00406.1 - 0.0096 15.8 2.5 0.082 12.9 2.5 2.4 1 1 0 1 1 1 1 PUB domain DUF5591 PF17884.1 ETO00407.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5591) zf-CCHC PF00098.23 ETO00408.1 - 0.0057 16.7 14.9 0.076 13.1 2.1 2.5 2 0 0 2 2 2 2 Zinc knuckle CorA PF01544.18 ETO00408.1 - 0.013 14.8 2.9 0.013 14.8 2.9 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein HEAT PF02985.22 ETO00409.1 - 1e-07 31.6 0.4 0.18 12.1 0.1 4.1 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ETO00409.1 - 8.2e-07 29.3 0.0 0.0015 18.8 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETO00409.1 - 9.3e-07 29.0 0.9 0.0053 16.8 0.2 2.0 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETO00409.1 - 0.00015 21.9 0.3 0.014 15.6 0.1 2.3 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ETO00409.1 - 0.00078 19.9 0.0 0.19 12.2 0.0 3.1 2 1 1 3 3 3 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO00409.1 - 0.00088 19.8 1.2 1.3 9.6 0.1 2.3 1 1 2 3 3 3 2 Vacuolar 14 Fab1-binding region ENTH PF01417.20 ETO00409.1 - 0.058 13.4 0.2 0.27 11.3 0.1 2.0 1 1 2 3 3 3 0 ENTH domain DNA_alkylation PF08713.11 ETO00409.1 - 0.092 12.4 0.2 6.2 6.5 0.1 2.0 1 1 1 2 2 2 0 DNA alkylation repair enzyme MSP7_C PF12948.7 ETO00409.1 - 0.11 13.2 1.8 12 6.5 0.2 2.7 1 1 2 3 3 3 0 MSP7-like protein C-terminal domain THUMP PF02926.17 ETO00411.1 - 0.046 13.8 4.2 2.5 8.2 1.2 2.5 2 1 0 2 2 2 0 THUMP domain WD40 PF00400.32 ETO00413.1 - 0.00023 21.9 2.7 0.00026 21.7 0.3 2.3 2 2 0 2 2 2 1 WD domain, G-beta repeat Exo_endo_phos_2 PF14529.6 ETO00414.1 - 4.9e-13 49.0 0.7 8.5e-13 48.2 0.7 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO00414.1 - 0.075 12.5 0.0 0.1 12.1 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DEP PF00610.21 ETO00416.1 - 3.5e-11 43.0 0.1 7e-11 42.0 0.1 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF3762 PF12591.8 ETO00416.1 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3762) Kelch_2 PF07646.15 ETO00417.1 - 7e-05 22.6 0.1 0.00016 21.5 0.1 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO00417.1 - 0.00052 20.0 0.1 0.00093 19.2 0.1 1.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO00417.1 - 0.0012 19.1 1.0 0.0097 16.2 0.2 2.4 1 1 1 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO00417.1 - 0.069 12.8 0.1 0.16 11.6 0.1 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_3 PF13415.6 ETO00417.1 - 0.1 12.9 0.0 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF1765 PF08578.10 ETO00419.1 - 8e-12 45.7 3.3 8e-12 45.7 3.3 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1765) Erf4 PF10256.9 ETO00419.1 - 0.45 10.6 5.2 0.16 12.1 0.6 2.6 3 0 0 3 3 3 0 Golgin subfamily A member 7/ERF4 family WD40 PF00400.32 ETO00420.1 - 0.00018 22.2 0.1 0.035 15.0 0.0 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat IMCp PF12314.8 ETO00420.1 - 0.023 15.0 0.4 0.049 13.9 0.4 1.6 1 0 0 1 1 1 0 Inner membrane complex protein GlcNAc-1_reg PF18440.1 ETO00420.1 - 0.04 14.2 1.2 0.04 14.2 1.2 2.0 1 1 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain FAM76 PF16046.5 ETO00420.1 - 1.8 7.9 14.0 0.46 9.8 11.2 1.4 2 0 0 2 2 2 0 FAM76 protein SspO PF08175.12 ETO00420.1 - 4.5 7.8 8.8 0.16 12.4 0.9 2.4 2 0 0 2 2 2 0 Small acid-soluble spore protein O family PPR_2 PF13041.6 ETO00421.1 - 2e-10 40.7 0.0 0.00076 19.6 0.0 2.8 2 1 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETO00421.1 - 0.00017 21.6 2.4 0.72 10.2 0.0 4.5 5 0 0 5 5 5 2 PPR repeat PPR_1 PF12854.7 ETO00421.1 - 0.0011 18.6 4.3 0.27 11.0 0.0 4.2 5 0 0 5 5 5 2 PPR repeat WD40 PF00400.32 ETO00423.1 - 9.2e-51 168.7 14.6 8.9e-11 42.2 0.1 5.0 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00423.1 - 1.6e-23 82.8 1.3 3.5e-06 27.2 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO00423.1 - 9.2e-13 48.2 0.7 4.5e-05 22.9 0.0 3.3 1 1 3 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO00423.1 - 4.2e-09 35.8 0.7 0.084 11.8 0.1 4.4 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 ETO00423.1 - 1.1e-08 35.0 0.2 8.2e-05 22.3 0.1 2.2 1 1 1 2 2 2 2 PQQ-like domain Frtz PF11768.8 ETO00423.1 - 8.7e-08 30.9 0.0 0.0028 16.0 0.0 3.3 2 2 1 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO00423.1 - 1e-07 31.7 2.6 7.1 6.7 0.0 5.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO00423.1 - 3.3e-05 22.7 0.0 1.2 7.7 0.0 3.6 1 1 3 4 4 4 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO00423.1 - 3.4e-05 23.9 8.0 2.3 8.3 0.1 4.0 1 1 3 4 4 4 3 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO00423.1 - 0.00022 20.2 0.0 0.37 9.6 0.0 2.3 1 1 1 2 2 2 2 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO00423.1 - 0.00046 18.8 0.6 0.35 9.3 0.0 2.8 1 1 3 4 4 4 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO00423.1 - 0.0036 16.1 0.1 7.9 5.1 0.0 3.6 1 1 2 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETO00423.1 - 0.0053 16.4 7.8 31 4.4 0.0 5.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO00423.1 - 0.022 14.7 0.0 76 3.5 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat DUF1258 PF06869.12 ETO00423.1 - 0.041 13.4 0.0 6.7 6.1 0.0 3.1 1 1 2 4 4 4 0 Protein of unknown function (DUF1258) DUF4242 PF14026.6 ETO00423.1 - 0.14 12.3 0.0 2.9 8.1 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF4242) CSN4_RPN5_eIF3a PF18420.1 ETO00423.1 - 0.29 11.3 9.0 51 4.1 0.1 4.3 4 0 0 4 4 4 0 CSN4/RPN5/eIF3a helix turn helix domain MlaD PF02470.20 ETO00423.1 - 0.3 11.4 2.1 1.3e+02 3.0 0.0 4.2 3 1 1 4 4 4 0 MlaD protein ubiquitin PF00240.23 ETO00424.1 - 5.3e-28 96.6 0.2 5.7e-28 96.5 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO00424.1 - 1e-12 47.7 0.3 1.1e-12 47.6 0.3 1.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO00424.1 - 1.7e-05 25.2 0.1 7.7e-05 23.1 0.1 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO00424.1 - 0.00079 19.7 0.1 0.0009 19.6 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO00424.1 - 0.0013 18.8 0.0 0.0038 17.3 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETO00424.1 - 0.0029 17.5 0.1 0.003 17.5 0.1 1.1 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ETO00424.1 - 0.0087 16.6 0.1 0.01 16.4 0.1 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO00424.1 - 0.15 12.1 0.2 1.7 8.8 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin-like domain YqfQ PF14181.6 ETO00425.1 - 0.0035 17.6 10.5 0.1 12.8 0.0 3.1 3 0 0 3 3 3 2 YqfQ-like protein HlyU PF10115.9 ETO00425.1 - 0.022 14.8 0.6 0.038 14.0 0.6 1.4 1 0 0 1 1 1 0 Transcriptional activator HlyU DUF2497 PF10691.9 ETO00426.1 - 0.034 14.6 0.2 0.13 12.7 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2497) YyzF PF14116.6 ETO00426.1 - 0.082 12.9 0.2 20 5.3 0.1 2.7 2 0 0 2 2 2 0 YyzF-like protein INT_SG_DDX_CT_C PF15300.6 ETO00426.1 - 0.088 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 INTS6/SAGE1/DDX26B/CT45 C-terminus Nuf2 PF03800.14 ETO00428.1 - 0.039 14.1 0.5 0.068 13.3 0.5 1.4 1 0 0 1 1 1 0 Nuf2 family TetR_C_6 PF13977.6 ETO00428.1 - 0.12 12.6 0.1 0.37 11.0 0.0 1.7 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal ArsR PF09824.9 ETO00429.1 - 0.037 13.6 4.6 0.065 12.8 2.8 2.1 2 1 0 2 2 2 0 ArsR transcriptional regulator YajC PF02699.15 ETO00429.1 - 0.4 10.6 4.5 1.2 9.1 0.4 2.7 3 0 0 3 3 3 0 Preprotein translocase subunit Myc_N PF01056.18 ETO00430.1 - 0.0082 16.1 6.9 0.0096 15.9 6.9 1.2 1 0 0 1 1 1 1 Myc amino-terminal region CLPTM1 PF05602.12 ETO00430.1 - 0.094 11.7 1.7 0.11 11.5 1.7 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Nucleo_P87 PF07267.11 ETO00430.1 - 1.1 8.0 10.1 1.6 7.5 10.1 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Presenilin PF01080.17 ETO00430.1 - 5.7 5.6 10.8 7.6 5.2 10.8 1.3 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO00430.1 - 6.9 5.9 12.1 9.9 5.4 12.1 1.3 1 0 0 1 1 1 0 NOA36 protein Prothymosin PF03247.14 ETO00430.1 - 8.3 6.9 19.7 27 5.3 19.7 1.9 1 1 0 1 1 1 0 Prothymosin/parathymosin family Kelch_1 PF01344.25 ETO00431.1 - 3.5e-08 32.9 4.0 5.6e-05 22.7 0.4 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO00431.1 - 1.4e-07 31.5 8.5 0.0022 18.2 0.7 4.4 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO00431.1 - 9.2e-06 25.4 5.8 0.016 15.2 0.1 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO00431.1 - 0.00022 21.2 2.9 0.0025 17.8 0.5 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00431.1 - 0.0006 19.7 8.4 0.1 12.7 0.4 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO00431.1 - 0.064 13.6 1.5 0.39 11.1 0.1 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain Renin_r PF07850.14 ETO00433.1 - 1.3 9.6 4.1 3.1 8.5 2.3 2.5 2 1 0 2 2 2 0 Renin receptor-like protein BUD22 PF09073.10 ETO00436.1 - 0.27 10.5 6.6 0.34 10.2 6.6 1.1 1 0 0 1 1 1 0 BUD22 FAM176 PF14851.6 ETO00436.1 - 0.3 10.8 5.4 0.46 10.1 5.4 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 ETO00436.1 - 0.63 10.1 11.0 0.79 9.7 9.2 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal Nop14 PF04147.12 ETO00436.1 - 0.7 8.0 12.3 0.91 7.7 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO00436.1 - 0.92 7.7 10.0 1.4 7.1 10.0 1.2 1 0 0 1 1 1 0 CDC45-like protein GCIP PF13324.6 ETO00436.1 - 1 8.9 10.0 1.7 8.2 10.0 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Slu7 PF11708.8 ETO00436.1 - 1.1 9.0 9.6 1.6 8.4 9.6 1.1 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor NOA36 PF06524.12 ETO00436.1 - 1.2 8.4 15.9 1.8 7.8 15.9 1.2 1 0 0 1 1 1 0 NOA36 protein Cytomega_UL84 PF06284.11 ETO00436.1 - 1.8 6.9 5.5 1.5 7.2 4.2 1.4 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein CENP-B_dimeris PF09026.10 ETO00436.1 - 2.8 8.4 18.1 5.2 7.5 18.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 ETO00436.1 - 2.9 8.2 13.9 9.3 6.5 13.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) SDA1 PF05285.12 ETO00436.1 - 4.4 6.6 14.0 3.1 7.1 12.6 1.4 2 0 0 2 2 2 0 SDA1 Cwf_Cwc_15 PF04889.12 ETO00436.1 - 5.2 6.7 16.0 7.9 6.1 16.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein HECT PF00632.25 ETO00437.1 - 1.6e-11 44.3 0.2 2.4e-11 43.7 0.2 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) REC1 PF18501.1 ETO00437.1 - 1.1 9.2 6.2 2 8.2 6.2 1.4 1 0 0 1 1 1 0 Alpha helical recognition lobe domain AAA_14 PF13173.6 ETO00439.1 - 0.23 11.5 1.4 11 6.0 0.2 2.2 1 1 1 2 2 2 0 AAA domain RVT_1 PF00078.27 ETO00440.1 - 0.0028 17.2 0.1 0.0042 16.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 ETO00441.1 - 2.5e-06 27.3 0.7 4.6e-06 26.5 0.5 1.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase ATP-sulfurylase PF01747.17 ETO00441.1 - 0.089 12.2 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 ATP-sulfurylase TPR_12 PF13424.6 ETO00443.1 - 1.1e-13 51.2 0.0 2.2e-06 27.9 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00443.1 - 3.2e-12 45.7 6.0 2.4e-05 24.0 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00443.1 - 4.1e-09 35.9 1.7 0.002 18.1 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00443.1 - 2e-08 33.8 2.9 0.0032 17.6 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00443.1 - 2.9e-07 30.0 0.0 0.00026 20.8 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00443.1 - 4.9e-07 29.4 0.0 0.012 15.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00443.1 - 0.0091 16.6 0.2 9.4 7.1 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00443.1 - 0.0092 15.7 2.5 3.4 7.4 0.2 3.3 3 0 0 3 3 3 1 TPR repeat Fis1_TPR_C PF14853.6 ETO00443.1 - 0.053 13.6 0.1 0.16 12.0 0.0 1.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 ETO00443.1 - 0.15 13.0 0.0 10 7.3 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00443.1 - 0.16 12.4 0.8 11 6.6 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat FHA PF00498.26 ETO00444.1 - 1.7e-10 41.1 0.2 3.1e-10 40.3 0.2 1.4 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ETO00444.1 - 1.4e-09 38.1 0.1 2.3e-09 37.5 0.1 1.2 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF677 PF05055.12 ETO00445.1 - 0.00016 20.7 3.7 0.00022 20.3 3.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF677) RNA_polI_A14 PF08203.11 ETO00445.1 - 0.0032 18.2 5.1 0.0054 17.4 5.1 1.4 1 0 0 1 1 1 1 Yeast RNA polymerase I subunit RPA14 UBA_3 PF09288.10 ETO00445.1 - 0.057 13.2 0.0 16 5.4 0.1 2.7 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain UBA_2 PF08587.11 ETO00445.1 - 1.1 9.5 0.0 1.1 9.5 0.0 3.0 4 0 0 4 4 4 0 Ubiquitin associated domain (UBA) Kelch_6 PF13964.6 ETO00446.1 - 0.0012 19.0 1.2 3.2 8.2 0.1 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO00446.1 - 0.0025 17.8 0.6 0.6 10.2 0.1 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Sec3-PIP2_bind PF15277.6 ETO00446.1 - 0.081 13.1 0.9 0.95 9.6 0.1 2.3 2 0 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH GF_recep_IV PF14843.6 ETO00446.1 - 0.095 12.5 1.1 0.15 11.9 1.1 1.3 1 0 0 1 1 1 0 Growth factor receptor domain IV Csm1_N PF18504.1 ETO00448.1 - 0.21 12.0 4.8 0.5 10.7 4.8 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain zf-C3HC4_2 PF13923.6 ETO00448.1 - 1.8 8.5 6.0 5.1 7.0 3.3 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Paired_CXXCH_1 PF09699.10 ETO00449.1 - 0.028 14.2 0.1 0.076 12.8 0.1 1.8 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-RING_5 PF14634.6 ETO00449.1 - 0.35 10.9 3.2 0.37 10.8 0.7 2.2 2 0 0 2 2 2 0 zinc-RING finger domain Presenilin PF01080.17 ETO00449.1 - 0.48 9.1 4.5 0.65 8.7 4.5 1.1 1 0 0 1 1 1 0 Presenilin zf-RING_2 PF13639.6 ETO00449.1 - 1.2 9.6 7.3 0.32 11.4 3.2 2.2 2 1 0 2 2 2 0 Ring finger domain YqfD PF06898.11 ETO00449.1 - 7.3 5.3 7.5 0.23 10.2 1.1 1.6 2 0 0 2 2 2 0 Putative stage IV sporulation protein YqfD HEAT PF02985.22 ETO00450.1 - 5.3e-06 26.2 1.2 0.00098 19.2 0.0 4.0 5 1 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 ETO00450.1 - 2.1e-05 24.6 0.1 4.1e-05 23.7 0.1 1.5 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO00450.1 - 6.1e-05 23.3 0.0 0.00012 22.4 0.0 1.5 1 1 0 1 1 1 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO00450.1 - 0.00094 19.7 0.0 0.027 15.0 0.0 2.3 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO00450.1 - 0.0012 18.4 0.0 0.0016 18.1 0.0 1.2 1 0 0 1 1 1 1 CLASP N terminal Arm-DNA-bind_2 PF12167.8 ETO00450.1 - 0.031 14.2 0.0 7.8 6.5 0.0 3.0 3 0 0 3 3 3 0 Arm DNA-binding domain TAN PF11640.8 ETO00450.1 - 0.098 12.8 0.7 0.19 11.8 0.7 1.6 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair Glyco_hydro_2_C PF02836.17 ETO00451.1 - 2.6e-23 82.6 0.5 4.5e-23 81.8 0.5 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2 PF00703.21 ETO00451.1 - 9.8e-07 29.4 1.2 2e-06 28.5 1.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 TPT PF03151.16 ETO00452.1 - 0.00013 21.4 6.1 0.00024 20.5 6.1 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ETO00452.1 - 0.18 12.0 11.8 0.49 10.6 9.2 2.4 2 1 0 2 2 2 0 EamA-like transporter family V-ATPase_H_C PF11698.8 ETO00454.1 - 0.028 14.5 0.9 0.076 13.1 0.9 1.7 1 0 0 1 1 1 0 V-ATPase subunit H PPR_2 PF13041.6 ETO00455.1 - 4.4e-09 36.4 7.6 0.0041 17.3 0.2 3.2 2 1 1 3 3 3 3 PPR repeat family PPR PF01535.20 ETO00455.1 - 7.3e-08 32.2 7.9 0.15 12.4 0.1 3.6 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 ETO00455.1 - 2e-05 24.6 0.4 0.00043 20.3 0.1 2.9 2 1 1 3 3 3 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO00455.1 - 5.6e-05 22.8 2.6 0.16 11.7 0.0 3.3 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 ETO00455.1 - 0.0048 16.3 0.1 0.0062 15.9 0.1 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DEP PF00610.21 ETO00457.1 - 0.00022 21.2 0.0 0.00045 20.2 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Taxilin PF09728.9 ETO00458.1 - 6.5e-06 25.5 35.7 0.0004 19.7 28.7 2.4 1 1 1 2 2 2 2 Myosin-like coiled-coil protein DUF3365 PF11845.8 ETO00458.1 - 0.12 12.7 1.7 0.27 11.6 1.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3365) DUF4156 PF13698.6 ETO00458.1 - 0.12 12.7 1.7 0.28 11.5 1.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4156) Ribosomal_S15 PF00312.22 ETO00458.1 - 0.2 11.9 7.3 0.21 11.8 0.2 2.7 3 0 0 3 3 3 0 Ribosomal protein S15 DUF948 PF06103.11 ETO00458.1 - 0.91 9.8 6.8 2.7 8.3 1.0 2.6 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1843 PF08898.10 ETO00458.1 - 1 9.9 7.6 6.8 7.3 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1843) Phage_1_1 PF08200.11 ETO00458.1 - 1.9 9.0 8.9 2 8.9 2.1 2.9 2 1 1 3 3 3 0 Bacteriophage 1.1 Protein Cortex-I_coil PF09304.10 ETO00458.1 - 5 7.4 17.8 0.22 11.8 1.4 3.6 1 1 1 3 3 3 0 Cortexillin I, coiled coil TPR_12 PF13424.6 ETO00459.1 - 3.6e-55 184.2 1.2 1.5e-18 66.8 0.1 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00459.1 - 4.1e-35 118.7 0.0 5.3e-11 42.0 0.0 4.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00459.1 - 6.3e-25 85.3 1.0 3.2e-08 33.0 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00459.1 - 3.7e-24 83.5 14.2 1.6e-08 34.0 0.3 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00459.1 - 2.6e-17 61.5 15.4 1.4e-05 24.9 0.3 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00459.1 - 3.7e-15 54.7 10.5 0.00017 21.4 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat MIT PF04212.18 ETO00459.1 - 9.1e-10 38.5 8.4 0.00078 19.5 0.1 4.0 3 1 1 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO00459.1 - 1.7e-09 37.4 3.1 0.0041 17.4 0.2 4.3 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO00459.1 - 4e-07 29.9 12.5 0.0034 17.3 0.9 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00459.1 - 1.3e-06 28.9 0.0 0.031 14.9 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00459.1 - 1.5e-06 28.5 0.0 2.4 9.2 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00459.1 - 1.3e-05 25.5 0.4 9.6 7.1 0.1 4.6 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO00459.1 - 5.8e-05 22.6 0.0 0.0002 20.8 0.0 1.6 1 1 0 1 1 1 1 MalT-like TPR region DUF5113 PF17140.4 ETO00459.1 - 0.0001 22.2 5.3 0.79 9.5 0.1 3.6 3 1 1 4 4 4 2 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO00459.1 - 0.00017 21.7 4.0 0.0077 16.4 0.9 2.9 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO00459.1 - 0.00063 20.2 0.0 2.8 8.5 0.0 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO00459.1 - 0.0048 16.4 0.9 32 4.2 0.0 4.4 4 1 0 4 4 4 0 Helix-turn-helix bacterial domain TPR_11 PF13414.6 ETO00459.1 - 0.006 16.2 13.5 5.8 6.7 0.1 5.3 4 1 1 5 5 5 1 TPR repeat FAIM1 PF06905.13 ETO00459.1 - 0.016 15.0 0.3 0.13 11.9 0.1 1.9 1 1 0 2 2 2 0 Fas apoptotic inhibitory molecule (FAIM1) Fis1_TPR_C PF14853.6 ETO00459.1 - 0.026 14.6 5.4 7.9 6.6 0.1 3.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF4810 PF16068.5 ETO00459.1 - 0.043 14.4 1.2 9.8 6.8 0.0 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF4810) PPR PF01535.20 ETO00459.1 - 0.067 13.5 3.4 16 6.0 0.1 3.6 4 0 0 4 4 4 0 PPR repeat HnRNPA1 PF11627.8 ETO00459.1 - 1.5 9.1 5.2 4.2 7.6 0.5 2.5 2 0 0 2 2 2 0 Nuclear factor hnRNPA1 DUF4624 PF15417.6 ETO00460.1 - 0.11 12.3 1.7 1 9.2 0.3 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4624) CinA_KH PF18146.1 ETO00460.1 - 0.15 12.2 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Damage-inducible protein CinA KH domain DUF587 PF04532.12 ETO00460.1 - 0.16 11.2 0.0 0.79 9.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF587) RPA_C PF08784.11 ETO00461.1 - 0.011 16.3 0.3 0.019 15.6 0.3 1.4 1 0 0 1 1 1 0 Replication protein A C terminal RNA_pol_Rpb8 PF03870.15 ETO00461.1 - 0.12 12.6 1.4 2.3 8.4 0.2 2.4 2 1 0 2 2 2 0 RNA polymerase Rpb8 AAR2 PF05282.11 ETO00462.1 - 0.26 10.6 4.4 0.29 10.5 4.4 1.1 1 0 0 1 1 1 0 AAR2 protein Pex14_N PF04695.13 ETO00463.1 - 0.12 13.1 4.4 0.15 12.7 4.4 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region POX PF07526.11 ETO00463.1 - 2.4 8.7 10.2 4.7 7.8 10.2 1.6 1 1 0 1 1 1 0 Associated with HOX CDC45 PF02724.14 ETO00463.1 - 3.4 5.9 15.3 3.6 5.8 15.3 1.0 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO00464.1 - 0.13 12.3 5.6 0.21 11.7 5.6 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Orf78 PF06024.12 ETO00464.1 - 5 7.5 5.7 48 4.3 0.2 2.8 2 0 0 2 2 2 0 Orf78 (ac78) YfbU PF03887.14 ETO00465.1 - 0.009 16.0 0.2 0.014 15.4 0.2 1.3 1 0 0 1 1 1 1 YfbU domain TPR_12 PF13424.6 ETO00467.1 - 1e-34 118.6 0.2 6e-13 48.9 0.0 4.0 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00467.1 - 1e-30 104.7 0.0 3.8e-09 36.1 0.0 4.6 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00467.1 - 4e-25 86.5 18.9 2.2e-08 33.6 0.6 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00467.1 - 5.9e-23 79.2 2.3 4.9e-07 29.3 0.0 4.7 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00467.1 - 5e-22 76.2 22.1 3.5e-08 33.0 1.7 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00467.1 - 5.7e-19 66.6 8.9 4.5e-07 29.5 0.3 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00467.1 - 5.4e-12 45.2 9.8 0.0015 18.8 0.1 5.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00467.1 - 1.9e-07 31.6 0.0 0.082 13.6 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00467.1 - 3.6e-07 30.4 0.3 0.11 13.2 0.0 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00467.1 - 6.3e-06 25.8 22.5 0.0028 17.3 1.2 6.0 5 2 3 8 8 8 3 TPR repeat ANAPC3 PF12895.7 ETO00467.1 - 0.00015 22.0 2.1 0.022 15.0 0.3 3.4 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETO00467.1 - 0.0002 21.9 0.0 0.47 11.4 0.0 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO00467.1 - 0.00026 20.8 9.6 0.056 13.3 0.2 3.7 3 2 2 5 5 5 2 Domain of unknown function (DUF5113) DUF4810 PF16068.5 ETO00467.1 - 0.01 16.3 0.6 48 4.6 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4810) TPR_3 PF07720.12 ETO00467.1 - 0.017 15.1 15.8 0.29 11.2 0.2 5.4 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO00467.1 - 0.038 14.5 0.0 10 6.7 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 ETO00467.1 - 0.04 13.3 2.2 0.94 8.8 1.2 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 ETO00467.1 - 0.098 12.4 1.3 23 4.6 0.1 3.2 3 1 0 3 3 3 0 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ETO00467.1 - 0.11 11.9 0.0 0.51 9.7 0.0 1.8 1 1 1 2 2 2 0 MalT-like TPR region MIT PF04212.18 ETO00467.1 - 0.34 11.0 9.7 2.1 8.5 1.4 3.6 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 ETO00467.1 - 0.54 11.0 5.5 22 5.9 0.3 4.5 5 1 0 5 5 5 0 Sel1 repeat PPR PF01535.20 ETO00467.1 - 0.95 9.9 12.8 5.9 7.4 0.1 4.9 5 0 0 5 5 5 0 PPR repeat DUF4363 PF14276.6 ETO00468.1 - 0.012 15.7 1.1 0.016 15.3 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4363) TBCA PF02970.16 ETO00468.1 - 0.027 14.8 0.9 0.24 11.8 0.2 2.2 2 1 0 2 2 2 0 Tubulin binding cofactor A DUF3426 PF11906.8 ETO00468.1 - 0.073 13.2 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3426) SR-25 PF10500.9 ETO00469.1 - 0.003 17.2 4.1 0.0032 17.1 4.1 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ETO00469.1 - 0.053 14.2 4.7 0.075 13.7 4.7 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein Secretin_N_2 PF07655.13 ETO00469.1 - 0.68 10.5 16.4 0.13 12.8 3.4 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain zf-C3HC4_3 PF13920.6 ETO00470.1 - 0.44 10.4 7.4 1.1 9.1 7.4 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO00470.1 - 0.58 10.5 9.3 0.093 13.1 4.4 2.1 1 1 1 2 2 2 0 RING-like domain zf-RING_2 PF13639.6 ETO00470.1 - 2.3 8.7 9.4 0.84 10.0 5.6 2.2 2 1 0 2 2 2 0 Ring finger domain RB_A PF01858.17 ETO00471.1 - 0.032 14.1 0.1 0.04 13.8 0.1 1.1 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain DUF3236 PF11576.8 ETO00472.1 - 0.049 13.3 0.1 0.15 11.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) TFIIA_gamma_N PF02268.16 ETO00474.1 - 1.9 8.6 4.4 2.7 8.1 0.0 3.0 4 0 0 4 4 4 0 Transcription initiation factor IIA, gamma subunit, helical domain HTH_ABP1_N PF18107.1 ETO00475.1 - 0.041 13.6 0.1 0.082 12.6 0.1 1.6 1 0 0 1 1 1 0 Fission yeast centromere protein N-terminal domain SLAC1 PF03595.17 ETO00478.1 - 0.038 13.3 2.1 0.053 12.8 2.1 1.1 1 0 0 1 1 1 0 Voltage-dependent anion channel TraH PF06122.11 ETO00478.1 - 0.049 12.9 0.0 0.067 12.5 0.0 1.1 1 0 0 1 1 1 0 Conjugative relaxosome accessory transposon protein HAUS6_N PF14661.6 ETO00479.1 - 0.01 15.4 0.2 0.011 15.3 0.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus BRF1 PF07741.13 ETO00480.1 - 0.04 14.3 4.9 0.06 13.7 2.6 2.4 2 0 0 2 2 2 0 Brf1-like TBP-binding domain GlcNAc PF11397.8 ETO00482.1 - 2.7e-32 112.6 0.4 3.5e-32 112.2 0.4 1.1 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) CooT PF10133.9 ETO00483.1 - 0.031 14.5 3.8 0.056 13.7 3.8 1.5 1 0 0 1 1 1 0 CO dehydrogenase accessory protein CooT Pannexin_like PF12534.8 ETO00483.1 - 0.05 12.7 2.8 0.029 13.5 1.5 1.3 1 1 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF2357 PF09823.9 ETO00484.1 - 0.0075 15.5 0.0 0.009 15.3 0.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF2357) ICEA PF05315.11 ETO00484.1 - 0.058 12.8 0.0 0.063 12.7 0.0 1.0 1 0 0 1 1 1 0 ICEA Protein DUF5308 PF17233.2 ETO00487.1 - 0.0061 16.8 0.4 0.0068 16.6 0.4 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5308) SMYLE_N PF18615.1 ETO00487.1 - 0.068 12.7 2.9 0.08 12.5 2.9 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Connexin PF00029.19 ETO00487.1 - 0.14 11.9 6.6 0.16 11.7 6.6 1.1 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 ETO00487.1 - 0.23 10.4 4.3 0.26 10.2 4.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO00487.1 - 0.27 10.0 2.3 0.3 9.8 2.3 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO00487.1 - 0.4 9.8 1.3 0.43 9.8 1.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TPR_2 PF07719.17 ETO00488.1 - 7e-10 38.3 0.7 0.00081 19.3 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00488.1 - 4.9e-09 36.0 1.0 0.013 15.8 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00488.1 - 7e-09 35.1 7.3 2e-05 24.2 0.1 3.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00488.1 - 0.00046 20.2 0.9 0.15 12.3 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO00488.1 - 0.0015 18.6 0.8 0.99 9.5 0.1 3.2 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 ETO00488.1 - 0.012 16.4 0.0 8.2 7.5 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO00488.1 - 0.017 15.6 0.2 17 6.0 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00488.1 - 0.028 14.1 7.7 0.85 9.4 0.6 4.2 4 2 0 4 4 4 0 TPR repeat DUF3808 PF10300.9 ETO00488.1 - 0.031 13.0 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Glutaredoxin PF00462.24 ETO00489.1 - 0.13 12.5 0.6 0.2 11.9 0.5 1.4 1 1 0 1 1 1 0 Glutaredoxin RNA_pol_RpbG PF16992.5 ETO00491.1 - 0.003 17.6 0.2 0.0048 16.9 0.1 1.4 1 1 0 1 1 1 1 DNA-directed RNA polymerase, subunit G ETC_C1_NDUFA4 PF04800.12 ETO00491.1 - 0.072 13.4 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 ETC complex I subunit conserved region Ploopntkinase2 PF18747.1 ETO00491.1 - 0.11 11.8 0.1 0.15 11.3 0.1 1.1 1 0 0 1 1 1 0 P-loop Nucleotide Kinase2 Actin PF00022.19 ETO00492.1 - 1.8e-33 115.8 0.0 2e-33 115.6 0.0 1.0 1 0 0 1 1 1 1 Actin RGS_DHEX PF18148.1 ETO00494.1 - 0.0072 16.4 0.6 0.0072 16.4 0.6 2.0 2 1 0 2 2 2 1 Regulator of G-protein signalling DHEX domain zf-HC5HC2H_2 PF13832.6 ETO00495.1 - 0.00021 21.4 1.9 0.00033 20.8 1.9 1.5 1 0 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO00495.1 - 0.00034 20.8 4.8 0.00065 19.9 4.8 1.6 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-RING-like PF08746.11 ETO00495.1 - 0.011 16.1 3.9 0.011 16.1 3.9 1.7 2 0 0 2 2 2 0 RING-like domain PHD PF00628.29 ETO00495.1 - 0.51 10.3 8.9 1.5 8.7 8.9 1.8 1 1 0 1 1 1 0 PHD-finger NRN1 PF15056.6 ETO00496.1 - 0.3 11.2 1.7 11 6.2 0.2 2.2 2 0 0 2 2 2 0 Neuritin protein family Spo0A_C PF08769.11 ETO00498.1 - 0.029 14.4 1.8 0.048 13.8 0.2 2.1 2 1 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal TolA_bind_tri PF16331.5 ETO00498.1 - 0.045 13.8 1.8 0.097 12.8 1.8 1.6 1 0 0 1 1 1 0 TolA binding protein trimerisation Nbl1_Borealin_N PF10444.9 ETO00498.1 - 0.073 12.7 4.1 3.1 7.5 0.1 3.4 2 1 1 3 3 3 0 Nbl1 / Borealin N terminal CLZ PF16526.5 ETO00498.1 - 0.076 13.4 7.5 0.41 11.0 3.6 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels APG6_N PF17675.1 ETO00498.1 - 0.11 13.0 9.4 0.22 12.1 9.4 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Muted PF14942.6 ETO00498.1 - 0.16 12.3 11.7 0.29 11.5 11.0 1.7 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Exonuc_VII_L PF02601.15 ETO00498.1 - 0.36 10.4 5.7 0.45 10.0 5.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETO00498.1 - 1.1 9.3 7.3 1.6 8.8 5.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 ETO00498.1 - 1.1 9.4 12.3 2.3 8.4 3.0 2.4 1 1 1 2 2 2 0 RasGAP C-terminus FlaC_arch PF05377.11 ETO00498.1 - 2 8.9 7.1 1.3 9.4 2.7 2.7 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 ETO00498.1 - 2 7.6 6.8 2.8 7.1 6.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein FlxA PF14282.6 ETO00498.1 - 2.7 8.1 10.9 5.1 7.1 10.3 1.7 1 1 0 1 1 1 0 FlxA-like protein DUF3535 PF12054.8 ETO00499.1 - 0.007 15.7 1.3 0.0077 15.5 1.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF3535) DUF1811 PF08838.10 ETO00500.1 - 0.021 15.0 4.2 0.059 13.6 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1811) OATP PF03137.20 ETO00501.1 - 0.58 8.4 4.1 0.86 7.8 4.1 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Zip PF02535.22 ETO00501.1 - 0.62 9.2 2.9 0.69 9.1 2.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter COG4 PF08318.12 ETO00501.1 - 1.5 7.8 14.8 1.8 7.6 12.2 1.9 1 1 1 2 2 2 0 COG4 transport protein Serinc PF03348.15 ETO00501.1 - 2.1 7.2 4.8 2.4 7.0 4.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) V_ATPase_I PF01496.19 ETO00501.1 - 7.4 4.4 16.2 7.7 4.3 16.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 ETO00501.1 - 7.5 5.5 6.8 8.5 5.3 6.8 1.3 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 ETO00501.1 - 7.6 4.8 9.4 8.4 4.7 9.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4775 PF16001.5 ETO00501.1 - 8.2 5.7 20.5 10 5.4 20.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Zn_ribbon_2 PF12674.7 ETO00502.1 - 0.017 15.7 0.8 0.024 15.3 0.8 1.2 1 0 0 1 1 1 0 Putative zinc ribbon domain SL4P PF17618.2 ETO00502.1 - 0.018 15.1 0.8 0.018 15.1 0.8 1.6 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein DEAD PF00270.29 ETO00502.1 - 0.071 12.9 0.1 0.085 12.6 0.1 1.2 1 0 0 1 1 1 0 DEAD/DEAH box helicase NACHT PF05729.12 ETO00503.1 - 0.011 15.6 0.0 0.011 15.6 0.0 1.1 1 0 0 1 1 1 0 NACHT domain DUF1359 PF07097.11 ETO00503.1 - 0.037 14.3 0.4 0.041 14.1 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1359) HSP70 PF00012.20 ETO00504.1 - 0.062 11.5 2.7 0.099 10.8 2.7 1.3 1 0 0 1 1 1 0 Hsp70 protein FAM176 PF14851.6 ETO00504.1 - 0.23 11.1 4.6 0.067 12.8 1.4 1.7 2 0 0 2 2 2 0 FAM176 family Ureide_permease PF07168.11 ETO00504.1 - 1.9 7.1 3.2 2.8 6.6 3.2 1.2 1 0 0 1 1 1 0 Ureide permease Ax_dynein_light PF10211.9 ETO00504.1 - 4 7.3 18.1 0.69 9.8 0.6 2.4 2 0 0 2 2 2 0 Axonemal dynein light chain PRC2_HTH_1 PF18118.1 ETO00504.1 - 7.5 7.4 15.5 2 9.2 10.6 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain WD40 PF00400.32 ETO00505.1 - 3e-115 372.8 57.8 5.1e-09 36.6 0.4 15.6 16 0 0 16 16 16 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00505.1 - 1.1e-25 89.7 16.8 0.0052 17.1 0.0 12.0 1 1 12 14 14 14 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO00505.1 - 3.3e-16 59.2 8.2 0.76 8.7 0.1 10.7 1 1 6 9 9 9 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO00505.1 - 2.4e-11 43.5 12.7 0.089 12.1 0.0 6.9 5 1 1 7 7 7 5 WD40-like domain Str_synth PF03088.16 ETO00505.1 - 6.6e-08 32.6 1.3 10 6.3 0.0 7.1 6 2 2 8 8 8 1 Strictosidine synthase Pentapeptide PF00805.22 ETO00505.1 - 7.3e-08 31.9 1.8 1.4e-07 31.0 1.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) eIF2A PF08662.11 ETO00505.1 - 6.4e-05 22.9 7.3 3.3 7.5 0.2 6.0 2 2 5 7 7 7 2 Eukaryotic translation initiation factor eIF2A Pentapeptide_4 PF13599.6 ETO00505.1 - 0.00011 22.3 0.1 0.00032 20.8 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO00505.1 - 0.00022 21.1 9.3 27 4.9 0.1 8.4 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat RE_XamI PF09572.10 ETO00505.1 - 0.00036 20.3 0.0 8.1 6.0 0.0 5.3 4 2 2 6 6 6 1 XamI restriction endonuclease Pentapeptide_3 PF13576.6 ETO00505.1 - 0.00087 19.4 0.6 0.0023 18.1 0.6 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Mid2 PF04478.12 ETO00505.1 - 0.00099 19.0 9.3 10 5.9 0.1 6.1 4 1 1 6 6 6 1 Mid2 like cell wall stress sensor DUF4988 PF16378.5 ETO00505.1 - 0.0023 17.7 1.9 3.7 7.2 0.0 4.5 4 1 0 5 5 5 2 Domain of unknown function DUF5319 PF17252.2 ETO00505.1 - 0.15 12.3 0.0 48 4.2 0.0 4.2 4 2 2 6 6 6 0 Family of unknown function (DUF5319) Hist_deacetyl PF00850.19 ETO00506.1 - 2.6e-09 37.0 0.0 5.5e-09 35.9 0.0 1.4 1 0 0 1 1 1 1 Histone deacetylase domain ubiquitin PF00240.23 ETO00507.1 - 3.7e-31 106.7 0.6 8.1e-31 105.6 0.6 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO00507.1 - 5.3e-14 51.8 0.3 5.3e-14 51.8 0.3 2.0 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO00507.1 - 2e-05 24.9 1.5 4.8e-05 23.7 0.1 2.3 2 1 0 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO00507.1 - 0.00077 19.3 0.6 0.0032 17.4 0.1 2.2 2 1 1 3 3 3 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO00507.1 - 0.0015 18.8 0.4 0.0015 18.8 0.4 1.8 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO00507.1 - 0.0039 17.3 0.1 0.0094 16.0 0.1 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO00507.1 - 0.028 15.0 0.1 0.039 14.5 0.1 1.3 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain zf-RanBP PF00641.18 ETO00508.1 - 1.7e-06 27.2 0.9 1.7e-06 27.2 0.9 2.5 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Rubredoxin_2 PF18073.1 ETO00508.1 - 0.022 14.5 0.1 0.022 14.5 0.1 2.6 4 0 0 4 4 4 0 Rubredoxin metal binding domain DZR PF12773.7 ETO00508.1 - 0.22 11.6 6.3 0.63 10.1 6.3 1.8 1 0 0 1 1 1 0 Double zinc ribbon SMC_N PF02463.19 ETO00509.1 - 0.12 11.7 0.0 0.18 11.2 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Tim54 PF11711.8 ETO00510.1 - 0.0011 17.8 0.5 0.0013 17.6 0.5 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 ETO00510.1 - 0.0019 16.6 5.9 0.0022 16.4 5.9 1.1 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 ETO00510.1 - 0.0055 16.2 7.4 0.0058 16.1 7.4 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO00510.1 - 0.017 13.4 6.2 0.017 13.4 6.2 1.1 1 0 0 1 1 1 0 Nop14-like family RPN2_C PF18004.1 ETO00510.1 - 0.025 14.5 2.4 0.038 13.9 2.4 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TFB6 PF17110.5 ETO00510.1 - 0.025 14.3 3.5 0.04 13.6 3.5 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NPR3 PF03666.13 ETO00510.1 - 0.03 13.1 10.5 0.019 13.8 8.2 1.6 1 1 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 ETO00510.1 - 0.032 13.1 3.0 0.033 13.0 3.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO00510.1 - 0.033 13.0 1.7 0.035 12.9 1.7 1.2 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ETO00510.1 - 0.041 12.0 7.7 0.048 11.8 7.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi PTPRCAP PF15713.5 ETO00510.1 - 0.064 13.6 8.8 0.11 12.8 8.8 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Sporozoite_P67 PF05642.11 ETO00510.1 - 0.068 11.3 2.1 0.079 11.0 2.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_Rpc4 PF05132.14 ETO00510.1 - 0.077 13.4 1.7 0.1 13.1 1.7 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 ETO00510.1 - 0.18 11.0 0.7 0.18 11.0 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2457 PF10446.9 ETO00510.1 - 0.19 10.9 14.2 0.22 10.6 14.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CPSF100_C PF13299.6 ETO00510.1 - 0.29 11.3 4.0 0.36 11.0 4.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ETO00510.1 - 0.86 9.3 2.7 1 9.0 2.7 1.2 1 0 0 1 1 1 0 Connexin Pox_Ag35 PF03286.14 ETO00510.1 - 1.1 9.0 12.6 1.5 8.5 12.6 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4820 PF16091.5 ETO00510.1 - 1.4 8.3 5.8 1.9 7.8 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CobT PF06213.12 ETO00510.1 - 2.9 7.2 11.0 4.4 6.6 11.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT V_ATPase_I PF01496.19 ETO00510.1 - 3.2 5.5 7.2 3.6 5.4 7.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RRN3 PF05327.11 ETO00510.1 - 3.7 6.0 9.0 4.2 5.8 9.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Menin PF05053.13 ETO00510.1 - 4.6 5.5 8.7 5.6 5.2 8.7 1.1 1 0 0 1 1 1 0 Menin FA_hydroxylase PF04116.13 ETO00511.1 - 0.26 11.7 3.5 0.21 11.9 1.5 1.8 2 0 0 2 2 2 0 Fatty acid hydroxylase superfamily FKBP_N PF01346.18 ETO00512.1 - 0.58 11.2 4.5 2.5 9.1 0.6 2.2 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase NIR_SIR PF01077.22 ETO00513.1 - 0.11 12.0 0.0 0.16 11.5 0.0 1.3 1 0 0 1 1 1 0 Nitrite and sulphite reductase 4Fe-4S domain MAP17 PF15807.5 ETO00514.1 - 0.12 12.7 1.3 0.47 10.7 0.0 2.0 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 ATP-synt_F6 PF05511.11 ETO00514.1 - 0.13 12.7 2.6 7.4 7.1 0.3 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 SpoIISA_toxin PF14171.6 ETO00514.1 - 0.39 10.4 8.0 0.26 11.0 3.5 2.0 1 1 1 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system WD40 PF00400.32 ETO00515.1 - 3.8e-16 59.2 10.6 5e-05 24.0 0.0 4.1 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO00515.1 - 1.3e-05 24.1 1.1 0.54 8.8 0.0 3.4 4 0 0 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00515.1 - 0.011 16.0 0.0 6.1 7.2 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain MMR_HSR1 PF01926.23 ETO00516.1 - 2.1e-07 31.0 0.2 3.2e-07 30.4 0.2 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ETO00516.1 - 0.0031 17.1 0.2 0.0061 16.1 0.1 1.5 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETO00516.1 - 0.0033 17.4 0.2 0.015 15.2 0.1 1.9 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ETO00516.1 - 0.0096 15.3 0.1 0.017 14.4 0.1 1.5 2 0 0 2 2 2 1 AIG1 family NAD_binding_7 PF13241.6 ETO00516.1 - 0.035 14.5 0.0 0.07 13.6 0.0 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding ABC_tran PF00005.27 ETO00516.1 - 0.042 14.4 0.1 0.11 13.0 0.2 1.7 2 1 0 2 2 2 0 ABC transporter DUF815 PF05673.13 ETO00516.1 - 0.097 11.8 0.1 0.17 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) DUF87 PF01935.17 ETO00516.1 - 0.15 12.1 0.8 0.23 11.5 0.2 1.5 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_5 PF07728.14 ETO00516.1 - 0.23 11.5 0.4 1.7 8.6 0.1 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TBCC_N PF16752.5 ETO00518.1 - 0.073 13.5 3.9 0.062 13.7 2.0 1.7 1 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF4363 PF14276.6 ETO00518.1 - 0.099 12.8 3.7 0.11 12.6 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) WD40 PF00400.32 ETO00519.1 - 5e-37 125.3 7.7 5.6e-11 42.8 0.1 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00519.1 - 3.5e-14 52.9 0.0 1.8e-05 24.9 0.0 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO00519.1 - 3.1e-09 36.6 0.1 0.0004 19.8 0.0 2.7 1 1 0 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO00519.1 - 1.2e-08 35.1 0.0 8.8e-05 22.5 0.0 1.9 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 ETO00519.1 - 0.00012 21.6 5.6 4 7.2 0.0 4.8 5 0 0 5 5 5 2 Proteasome subunit A N-terminal signature Ge1_WD40 PF16529.5 ETO00519.1 - 0.00018 20.6 0.0 1.9 7.4 0.0 3.5 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO00519.1 - 0.0007 18.4 0.0 0.71 8.4 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO00519.1 - 0.002 18.0 3.0 4.8 7.2 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat PLD_C PF12357.8 ETO00519.1 - 0.0031 17.4 0.0 0.3 11.0 0.0 2.8 1 1 2 3 3 3 1 Phospholipase D C terminal Cytochrom_D1 PF02239.16 ETO00519.1 - 0.0037 15.9 0.6 0.98 7.9 0.1 2.1 1 1 0 2 2 2 2 Cytochrome D1 heme domain DUF5122 PF17164.4 ETO00519.1 - 0.0089 16.3 1.3 1.7 9.0 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF5122) beta-propeller Cuticle_1 PF08140.11 ETO00519.1 - 0.014 15.4 0.4 12 6.0 0.0 3.9 4 1 1 5 5 5 0 Crustacean cuticle protein repeat DUF4221 PF13970.6 ETO00519.1 - 0.026 14.1 0.2 1.4 8.4 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) TRAP-delta PF05404.12 ETO00519.1 - 0.029 13.9 0.1 1.3 8.5 0.1 2.0 1 1 1 2 2 2 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) DUF5570 PF17731.1 ETO00519.1 - 0.047 13.8 0.4 7.7 6.6 0.1 2.6 1 1 2 3 3 3 0 Family of unknown function (DUF5570) Reg_prop PF07494.11 ETO00519.1 - 0.051 13.8 0.1 24 5.6 0.0 3.4 3 0 0 3 3 3 0 Two component regulator propeller Nbas_N PF15492.6 ETO00519.1 - 0.058 12.7 0.4 0.4 10.0 0.2 2.0 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal CSN4_RPN5_eIF3a PF18420.1 ETO00519.1 - 0.06 13.5 2.7 6.3 7.0 0.1 3.1 3 0 0 3 3 3 0 CSN4/RPN5/eIF3a helix turn helix domain DPPIV_N PF00930.21 ETO00519.1 - 0.069 11.9 0.1 16 4.1 0.0 3.0 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ank_3 PF13606.6 ETO00521.1 - 9.9e-07 28.6 0.7 0.00021 21.5 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO00521.1 - 3.6e-06 27.1 0.2 1e-05 25.7 0.2 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO00521.1 - 0.00037 21.0 0.9 0.00089 19.8 0.5 1.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO00521.1 - 0.00095 19.5 0.4 0.0059 17.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO00521.1 - 0.017 15.7 1.5 0.21 12.2 0.7 2.6 2 1 1 3 3 3 0 Ankyrin repeats (many copies) HTH_54 PF18607.1 ETO00521.1 - 0.028 14.5 0.0 0.057 13.5 0.0 1.5 1 0 0 1 1 1 0 ParA helix turn helix domain Sacchrp_dh_NADP PF03435.18 ETO00521.1 - 0.16 12.2 0.0 0.21 11.9 0.0 1.3 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain WES_acyltransf PF03007.16 ETO00522.1 - 2.1e-06 27.7 0.0 0.04 13.7 0.0 2.6 2 1 0 2 2 2 2 Wax ester synthase-like Acyl-CoA acyltransferase domain Secretin_N_2 PF07655.13 ETO00522.1 - 0.00068 20.1 14.7 0.0028 18.2 1.7 2.3 2 0 0 2 2 2 2 Secretin N-terminal domain Raftlin PF15250.6 ETO00522.1 - 0.022 13.5 0.3 0.033 13.0 0.3 1.2 1 0 0 1 1 1 0 Raftlin IMUP PF15761.5 ETO00522.1 - 0.076 13.7 10.7 0.18 12.5 10.7 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SR-25 PF10500.9 ETO00522.1 - 0.11 12.1 15.8 0.046 13.3 13.2 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 ETO00522.1 - 0.29 9.6 7.0 0.32 9.5 7.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF2076 PF09849.9 ETO00522.1 - 5.1 7.1 6.8 26 4.7 5.0 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Copine PF07002.16 ETO00523.1 - 2.1e-16 60.1 0.3 2.7e-14 53.1 0.0 2.1 2 0 0 2 2 2 2 Copine PAP2_C PF14360.6 ETO00524.1 - 1.6e-16 60.6 11.9 1.6e-16 60.6 11.9 2.0 2 0 0 2 2 2 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ETO00524.1 - 3e-07 30.3 3.6 3e-07 30.3 3.6 2.0 2 0 0 2 2 2 1 PAP2 superfamily PAP2_3 PF14378.6 ETO00524.1 - 0.007 16.1 7.8 0.011 15.4 7.8 1.4 1 1 0 1 1 1 1 PAP2 superfamily Kinesin PF00225.23 ETO00525.1 - 0.012 14.6 0.0 0.014 14.3 0.0 1.1 1 0 0 1 1 1 0 Kinesin motor domain Ank_2 PF12796.7 ETO00526.1 - 2.9e-06 27.8 0.3 3.8e-06 27.4 0.3 1.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO00526.1 - 7.7e-06 26.1 0.2 1.6e-05 25.1 0.2 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO00526.1 - 7.4e-05 22.9 0.3 0.0027 18.1 0.0 2.9 2 1 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO00526.1 - 0.0073 16.9 0.2 0.015 15.8 0.2 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO00526.1 - 0.012 16.0 0.1 0.047 14.1 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeat Caldesmon PF02029.15 ETO00527.1 - 5.9 5.5 59.5 6.9 5.3 59.5 1.1 1 0 0 1 1 1 0 Caldesmon Polysacc_deac_1 PF01522.21 ETO00528.1 - 0.056 13.4 1.9 0.098 12.6 1.9 1.6 1 1 0 1 1 1 0 Polysaccharide deacetylase SprA-related PF12118.8 ETO00528.1 - 0.16 11.1 5.1 0.24 10.5 5.1 1.2 1 0 0 1 1 1 0 SprA-related family CYLD_phos_site PF16607.5 ETO00530.1 - 0.51 10.2 8.1 0.78 9.6 8.1 1.3 1 0 0 1 1 1 0 Phosphorylation region of CYLD, unstructured Tox-PLDMTX PF15645.6 ETO00531.1 - 0.064 13.5 2.5 0.12 12.6 2.5 1.6 1 1 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold GlutR_dimer PF00745.20 ETO00532.1 - 4.1 7.9 9.1 3.3 8.2 0.5 3.7 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain RsgA_GTPase PF03193.16 ETO00533.1 - 2.9e-06 27.3 0.1 0.00013 21.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO00533.1 - 2.6e-05 24.2 0.6 0.00028 20.9 0.1 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETO00533.1 - 0.00023 21.3 0.3 0.33 11.0 0.0 2.5 1 1 0 2 2 2 2 Dynamin family ABC_tran PF00005.27 ETO00533.1 - 0.00027 21.5 0.0 0.00041 20.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_28 PF13521.6 ETO00533.1 - 0.0036 17.5 0.2 0.0071 16.6 0.2 1.7 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ETO00533.1 - 0.0046 16.1 0.0 0.006 15.7 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_29 PF13555.6 ETO00533.1 - 0.0053 16.5 0.0 0.0095 15.7 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.6 ETO00533.1 - 0.0082 16.5 0.0 0.011 16.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETO00533.1 - 0.018 14.6 0.1 0.031 13.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TAA-Trp-ring PF15401.6 ETO00533.1 - 0.021 15.3 0.3 0.057 13.9 0.3 1.8 1 0 0 1 1 1 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin SRP54 PF00448.22 ETO00533.1 - 0.04 13.6 0.1 0.076 12.6 0.1 1.5 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain PhoH PF02562.16 ETO00533.1 - 0.042 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein MCM PF00493.23 ETO00533.1 - 0.043 12.9 0.0 0.061 12.4 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain Septin PF00735.18 ETO00533.1 - 0.046 13.0 0.0 0.09 12.0 0.0 1.5 1 0 0 1 1 1 0 Septin CoA_trans PF01144.23 ETO00533.1 - 0.051 13.0 0.0 0.072 12.5 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase DUF815 PF05673.13 ETO00533.1 - 0.055 12.6 0.0 0.089 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ETO00533.1 - 0.082 13.3 0.0 0.21 12.0 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 ETO00533.1 - 0.082 12.2 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 ETO00533.1 - 0.13 12.5 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO00533.1 - 0.16 12.0 0.1 0.3 11.1 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ETO00533.1 - 0.16 11.6 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO00533.1 - 3.9 7.9 7.8 1.3 9.5 4.1 1.9 1 1 1 2 2 2 0 AAA domain GDA1_CD39 PF01150.17 ETO00534.1 - 1.9e-05 23.5 2.2 2.4e-05 23.2 2.2 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family GDA1_CD39 PF01150.17 ETO00535.1 - 9.3e-45 153.0 0.0 1.2e-44 152.7 0.0 1.0 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family KOW PF00467.29 ETO00535.1 - 0.0019 18.1 0.0 0.0041 17.0 0.0 1.6 1 0 0 1 1 1 1 KOW motif ANAPC4_WD40 PF12894.7 ETO00540.1 - 0.024 14.9 0.0 0.066 13.5 0.0 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S9_N PF02897.15 ETO00540.1 - 0.037 12.8 0.0 0.045 12.6 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase, N-terminal beta-propeller domain HCO3_cotransp PF00955.21 ETO00541.1 - 0.0028 16.5 0.4 0.0033 16.3 0.4 1.0 1 0 0 1 1 1 1 HCO3- transporter family Otopetrin PF03189.13 ETO00541.1 - 0.017 13.9 0.5 0.021 13.7 0.5 1.2 1 0 0 1 1 1 0 Otopetrin Zip PF02535.22 ETO00541.1 - 0.081 12.1 0.2 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Phage_holin_3_6 PF07332.11 ETO00541.1 - 0.13 12.3 0.1 0.18 11.9 0.1 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Secretin_N_2 PF07655.13 ETO00541.1 - 0.24 11.9 12.2 0.36 11.4 12.2 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 ETO00541.1 - 1.1 7.6 7.0 1.3 7.3 7.0 1.1 1 0 0 1 1 1 0 Menin CrgA PF06781.12 ETO00541.1 - 6.5 6.9 7.7 0.3 11.2 0.7 2.3 2 1 0 2 2 2 0 Cell division protein CrgA Kelch_2 PF07646.15 ETO00544.1 - 0.0086 16.0 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 Kelch motif SecA_DEAD PF07517.14 ETO00545.1 - 0.077 12.3 0.3 0.34 10.1 0.0 2.4 2 1 0 2 2 2 0 SecA DEAD-like domain TetR_C_37 PF18665.1 ETO00545.1 - 3.1 8.5 11.1 2.3 8.8 1.3 3.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Syntaxin_2 PF14523.6 ETO00547.1 - 0.0013 19.1 3.8 0.0021 18.4 3.8 1.4 1 0 0 1 1 1 1 Syntaxin-like protein COG2 PF06148.11 ETO00547.1 - 0.014 15.5 2.1 0.014 15.5 2.1 1.4 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 GatB_Yqey PF02637.18 ETO00547.1 - 0.017 15.0 5.1 0.021 14.7 5.1 1.2 1 0 0 1 1 1 0 GatB domain DUF4522 PF15022.6 ETO00547.1 - 0.15 12.3 5.0 0.075 13.3 2.7 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4522) SKA2 PF16740.5 ETO00547.1 - 0.16 11.8 7.6 0.23 11.2 2.0 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 FUN14 PF04930.15 ETO00547.1 - 0.53 10.7 2.6 0.88 10.0 2.6 1.6 1 1 0 1 1 1 0 FUN14 family TMPIT PF07851.13 ETO00547.1 - 1.9 7.6 7.5 2.2 7.5 7.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein PseudoU_synth_2 PF00849.22 ETO00548.1 - 2.6e-06 27.6 1.0 4.3e-06 26.9 0.5 1.7 2 1 0 2 2 2 1 RNA pseudouridylate synthase Drc1-Sld2 PF11719.8 ETO00548.1 - 0.0057 16.3 2.3 0.009 15.6 2.3 1.2 1 0 0 1 1 1 1 DNA replication and checkpoint protein Minor_capsid_1 PF10665.9 ETO00548.1 - 0.072 13.3 0.6 0.13 12.5 0.6 1.5 1 0 0 1 1 1 0 Minor capsid protein BORCS6 PF10157.9 ETO00550.1 - 0.00061 20.0 0.0 0.00065 20.0 0.0 1.1 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 6 PUB PF09409.10 ETO00550.1 - 0.056 13.4 1.6 0.12 12.3 1.6 1.7 1 1 0 1 1 1 0 PUB domain Nbs1_C PF08599.10 ETO00551.1 - 2.7 8.2 8.4 24 5.2 0.6 3.6 3 0 0 3 3 3 0 DNA damage repair protein Nbs1 Dsl1_C PF11989.8 ETO00552.1 - 0.0048 16.6 0.7 0.0054 16.5 0.7 1.1 1 0 0 1 1 1 1 Retrograde transport protein Dsl1 C terminal DUF247 PF03140.15 ETO00553.1 - 0.059 12.6 0.1 0.2 10.8 0.1 1.7 1 1 1 2 2 2 0 Plant protein of unknown function DUF3443 PF11925.8 ETO00553.1 - 0.077 11.8 0.1 0.15 10.9 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3443) SAM_decarbox PF01536.16 ETO00554.1 - 1e-35 123.4 0.3 1.3e-35 123.1 0.3 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase CPSF100_C PF13299.6 ETO00554.1 - 0.047 13.9 0.6 0.06 13.5 0.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Folate_carrier PF01770.18 ETO00554.1 - 0.082 11.6 3.1 0.11 11.2 3.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier GOLD_2 PF13897.6 ETO00554.1 - 0.13 12.8 0.1 0.18 12.3 0.1 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Apc15p PF05841.11 ETO00554.1 - 0.8 10.5 14.1 1.1 10.0 14.1 1.2 1 0 0 1 1 1 0 Apc15p protein Secretin_N_2 PF07655.13 ETO00554.1 - 1.1 9.9 17.8 1.7 9.3 17.8 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Orf78 PF06024.12 ETO00554.1 - 1.6 9.0 8.8 2.4 8.5 8.8 1.2 1 0 0 1 1 1 0 Orf78 (ac78) SelP_N PF04592.14 ETO00555.1 - 0.008 15.6 11.4 0.018 14.4 11.4 1.5 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Zip PF02535.22 ETO00555.1 - 1.6 7.9 8.4 3.5 6.8 8.4 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter PBP1_TM PF14812.6 ETO00555.1 - 6 7.3 7.4 0.57 10.6 2.7 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RGS PF00615.19 ETO00556.1 - 9.7e-11 42.0 1.8 1.8e-10 41.1 1.8 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Vps55 PF04133.14 ETO00556.1 - 0.031 14.2 3.4 0.66 10.0 0.8 2.3 1 1 1 2 2 2 0 Vacuolar protein sorting 55 TMEM156 PF15106.6 ETO00556.1 - 0.62 9.5 5.2 6.3 6.2 0.4 2.7 3 0 0 3 3 3 0 TMEM156 protein family RRM_5 PF13893.6 ETO00558.1 - 1.1e-21 76.7 0.2 3.2e-21 75.2 0.2 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO00558.1 - 1.8e-10 40.5 0.1 1.5e-06 27.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO00558.1 - 0.00012 21.9 0.0 0.0019 18.0 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif CAP_GLY PF01302.25 ETO00560.1 - 4.2e-17 61.9 0.0 6.8e-17 61.2 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain Ubiquitin_2 PF14560.6 ETO00560.1 - 3.1e-14 53.2 0.3 1.4e-13 51.0 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain YqhG PF11079.8 ETO00560.1 - 0.024 13.6 0.2 0.029 13.4 0.2 1.1 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function ACCA PF03255.14 ETO00560.1 - 0.063 13.2 0.3 0.12 12.3 0.3 1.3 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ndc1_Nup PF09531.10 ETO00561.1 - 0.55 8.9 3.2 0.67 8.6 3.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NRBF2 PF08961.10 ETO00561.1 - 0.57 9.8 16.0 0.36 10.4 1.1 2.9 1 1 2 3 3 3 0 Nuclear receptor-binding factor 2, autophagy regulator DUF4407 PF14362.6 ETO00561.1 - 1.2 8.5 15.1 1.3 8.3 15.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ETO00561.1 - 2.2 7.8 11.4 2.4 7.7 11.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Atg14 PF10186.9 ETO00561.1 - 5.6 6.0 18.7 6.7 5.7 18.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NACHT PF05729.12 ETO00564.1 - 9.4e-07 28.9 0.0 1.1e-06 28.7 0.0 1.0 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETO00564.1 - 0.049 13.6 0.0 0.16 11.9 0.0 2.0 1 1 0 1 1 1 0 STI1 domain PAN_3 PF08277.12 ETO00564.1 - 0.051 13.4 1.5 0.064 13.1 0.3 1.8 2 0 0 2 2 2 0 PAN-like domain Hydrolase PF00702.26 ETO00567.1 - 9.7e-06 26.0 0.0 1e-05 25.9 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETO00567.1 - 0.0034 17.5 0.0 0.0048 17.0 0.0 1.2 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO00567.1 - 0.011 16.1 0.0 0.013 15.9 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SIS PF01380.22 ETO00567.1 - 0.049 13.5 0.0 0.054 13.3 0.0 1.1 1 0 0 1 1 1 0 SIS domain ADH_zinc_N PF00107.26 ETO00567.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-binding dehydrogenase DUF669 PF05037.13 ETO00568.1 - 0.00078 19.6 1.0 0.001 19.2 0.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF669) Tnp_22_trimer PF17489.2 ETO00568.1 - 0.15 12.0 0.3 0.15 12.0 0.3 2.7 3 0 0 3 3 3 0 L1 transposable element trimerization domain RRM_1 PF00076.22 ETO00569.1 - 9.1e-18 63.8 0.8 3e-07 30.2 0.4 3.8 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) HEAT PF02985.22 ETO00570.1 - 4.9e-08 32.6 0.0 0.0029 17.7 0.0 2.7 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO00570.1 - 0.00011 22.5 0.0 0.00023 21.5 0.0 1.5 2 0 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 ETO00570.1 - 0.0086 16.1 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 RsbRD_N PF14361.6 ETO00570.1 - 0.013 16.2 0.1 0.13 13.0 0.1 2.3 1 1 0 1 1 1 0 RsbT co-antagonist protein rsbRD N-terminal domain HEAT_PBS PF03130.16 ETO00570.1 - 0.014 16.0 0.0 11 7.1 0.0 2.7 2 1 0 2 2 2 0 PBS lyase HEAT-like repeat DUF1102 PF06510.11 ETO00571.1 - 0.005 17.0 0.1 0.17 12.1 0.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF1102) RVT_1 PF00078.27 ETO00572.1 - 1.5e-33 116.2 0.0 1.6e-33 116.1 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) APG5 PF04106.12 ETO00573.1 - 0.022 14.4 0.1 0.022 14.3 0.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg5 Myco_arth_vir_N PF09610.10 ETO00573.1 - 0.096 12.8 1.6 0.096 12.8 1.6 3.3 3 0 0 3 3 3 0 Mycoplasma virulence signal region (Myco_arth_vir_N) RAB3GAP2_N PF14655.6 ETO00574.1 - 0.0072 15.6 0.0 0.0085 15.4 0.0 1.0 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus WD40 PF00400.32 ETO00575.1 - 5e-07 30.3 0.7 7.9e-06 26.5 0.1 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Mod_r PF07200.13 ETO00575.1 - 0.0015 18.7 5.5 0.002 18.3 5.5 1.1 1 0 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein CCDC-167 PF15188.6 ETO00575.1 - 0.022 15.1 1.8 0.035 14.4 1.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 MCU PF04678.13 ETO00575.1 - 0.044 13.9 1.5 0.058 13.5 1.5 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter FlxA PF14282.6 ETO00575.1 - 0.12 12.4 9.6 0.16 12.0 9.6 1.2 1 0 0 1 1 1 0 FlxA-like protein DUF3941 PF13081.6 ETO00575.1 - 3.1 8.3 8.6 0.17 12.3 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3941) DUF4735 PF15882.5 ETO00577.1 - 0.0054 16.2 6.3 0.0056 16.2 5.2 1.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4735) Tom7 PF08038.12 ETO00578.1 - 0.00028 20.5 0.4 0.00063 19.4 0.4 1.5 1 0 0 1 1 1 1 TOM7 family SH PF01445.17 ETO00579.1 - 0.075 13.0 3.4 2 8.5 2.7 2.8 2 0 0 2 2 2 0 Viral small hydrophobic protein EamA PF00892.20 ETO00579.1 - 2.2 8.4 10.4 0.085 13.0 4.6 1.6 2 0 0 2 2 2 0 EamA-like transporter family Metallophos_C PF14008.6 ETO00580.1 - 5.5e-16 59.2 0.4 2.8e-15 56.9 0.1 2.2 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 ETO00580.1 - 5.1e-11 43.5 0.1 9.1e-11 42.6 0.1 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Geminin PF07412.12 ETO00581.1 - 0.0053 16.5 4.5 0.0053 16.5 4.5 3.0 2 1 1 3 3 3 1 Geminin M_domain PF12938.7 ETO00581.1 - 0.031 14.1 12.5 0.081 12.7 5.5 2.1 2 0 0 2 2 2 0 M domain of GW182 AMP-binding PF00501.28 ETO00581.1 - 0.033 12.8 0.8 0.038 12.6 0.8 1.1 1 0 0 1 1 1 0 AMP-binding enzyme Csm1_N PF18504.1 ETO00581.1 - 0.053 13.9 23.3 0.27 11.6 3.8 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain Phage_HK97_TLTM PF06120.11 ETO00581.1 - 0.14 11.3 14.2 0.15 11.2 14.2 1.0 1 0 0 1 1 1 0 Tail length tape measure protein DUF641 PF04859.12 ETO00581.1 - 0.23 11.8 15.7 0.33 11.3 4.5 2.5 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF724 PF05266.14 ETO00581.1 - 0.25 11.1 18.5 0.029 14.2 10.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Fez1 PF06818.15 ETO00581.1 - 0.32 11.4 16.2 0.38 11.2 15.5 1.5 1 1 0 1 1 1 0 Fez1 DUF4407 PF14362.6 ETO00581.1 - 1.2 8.5 8.3 1.5 8.1 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 ETO00581.1 - 1.7 9.3 19.4 9.3 6.9 18.8 2.1 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Atg14 PF10186.9 ETO00581.1 - 1.8 7.6 14.9 2 7.4 14.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4140 PF13600.6 ETO00581.1 - 9.2 6.8 8.7 93 3.6 8.6 2.3 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) RRN3 PF05327.11 ETO00582.1 - 0.017 13.7 3.2 0.019 13.6 3.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pex26 PF07163.12 ETO00582.1 - 0.071 12.4 0.0 0.092 12.0 0.0 1.1 1 0 0 1 1 1 0 Pex26 protein NACHT_N PF17100.5 ETO00582.1 - 0.1 12.4 2.2 0.16 11.8 2.2 1.2 1 0 0 1 1 1 0 N-terminal domain of NWD NACHT-NTPase B56 PF01603.20 ETO00583.1 - 3.9e-111 372.0 3.0 4.3e-111 371.8 3.0 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DUF2513 PF10711.9 ETO00585.1 - 0.024 14.9 0.1 0.41 11.0 0.0 2.5 2 0 0 2 2 2 0 Hypothetical protein (DUF2513) AAA PF00004.29 ETO00585.1 - 0.044 14.2 0.0 0.092 13.2 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO00585.1 - 0.077 13.0 0.1 1.2 9.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO00585.1 - 0.083 13.2 0.0 0.54 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO00585.1 - 0.13 12.7 0.0 0.42 11.0 0.0 1.9 2 1 0 2 2 2 0 AAA ATPase domain DUF4549 PF15082.6 ETO00587.1 - 0.05 13.4 3.3 4.5 7.1 0.1 3.0 2 1 1 4 4 4 0 Domain of unknown function (DUF4549) JAB PF01398.21 ETO00590.1 - 4.2e-18 65.4 0.0 1e-17 64.2 0.0 1.7 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ETO00590.1 - 0.0013 18.5 0.0 0.0028 17.4 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain MGC-24 PF05283.11 ETO00590.1 - 1.7 9.1 11.2 4 7.9 11.2 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Nucleo_P87 PF07267.11 ETO00590.1 - 3.6 6.3 6.6 4.3 6.1 6.6 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MAP65_ASE1 PF03999.12 ETO00590.1 - 5.3 5.6 12.7 5.7 5.5 12.7 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) 14-3-3 PF00244.20 ETO00591.1 - 4.8e-54 183.2 4.3 4.7e-36 124.4 0.3 2.2 1 1 1 2 2 2 2 14-3-3 protein Exo_endo_phos_2 PF14529.6 ETO00592.1 - 6.1e-10 39.0 0.2 7.3e-10 38.7 0.2 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase UL20 PF17582.2 ETO00592.1 - 0.032 13.5 0.0 0.033 13.5 0.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL20 Exo_endo_phos PF03372.23 ETO00592.1 - 0.09 12.3 0.1 0.09 12.3 0.1 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family TetR_C_17 PF17922.1 ETO00593.1 - 0.1 12.7 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Lebercilin PF15619.6 ETO00595.1 - 0.00013 21.7 12.9 0.00016 21.4 12.9 1.1 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease AAA_13 PF13166.6 ETO00595.1 - 0.0051 15.5 4.6 0.0056 15.4 4.6 1.2 1 0 0 1 1 1 1 AAA domain Apolipoprotein PF01442.18 ETO00595.1 - 0.014 15.3 6.0 0.024 14.5 6.0 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Tup_N PF08581.10 ETO00595.1 - 0.022 15.1 4.2 0.022 15.1 4.2 1.7 2 0 0 2 2 2 0 Tup N-terminal LOH1CR12 PF10158.9 ETO00595.1 - 0.033 14.2 2.1 0.042 13.9 2.1 1.2 1 0 0 1 1 1 0 Tumour suppressor protein DUF5339 PF17274.2 ETO00595.1 - 0.041 14.7 5.4 0.18 12.7 4.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5339) HisKA_3 PF07730.13 ETO00595.1 - 0.077 13.5 2.1 0.54 10.8 2.1 2.2 1 1 0 1 1 1 0 Histidine kinase Syntaxin_2 PF14523.6 ETO00595.1 - 0.11 12.9 7.8 0.21 11.9 7.8 1.5 1 0 0 1 1 1 0 Syntaxin-like protein FAM76 PF16046.5 ETO00595.1 - 0.12 11.7 6.4 0.13 11.5 6.4 1.1 1 0 0 1 1 1 0 FAM76 protein CENP-K PF11802.8 ETO00595.1 - 0.12 11.9 10.0 0.17 11.5 10.0 1.2 1 0 0 1 1 1 0 Centromere-associated protein K HARP PF07443.13 ETO00595.1 - 0.12 12.0 0.5 0.27 10.9 0.1 1.8 2 0 0 2 2 2 0 HepA-related protein (HARP) WASH_WAHD PF11945.8 ETO00595.1 - 0.16 11.5 5.3 0.21 11.1 5.3 1.2 1 0 0 1 1 1 0 WAHD domain of WASH complex DUF4094 PF13334.6 ETO00595.1 - 0.16 12.4 6.6 0.42 11.1 6.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) MICSWaP PF17018.5 ETO00595.1 - 0.17 11.4 2.8 0.28 10.7 2.8 1.3 1 0 0 1 1 1 0 Spore wall protein DUF1664 PF07889.12 ETO00595.1 - 0.18 11.8 7.6 0.28 11.2 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ING PF12998.7 ETO00595.1 - 0.25 11.9 7.1 0.41 11.2 7.1 1.3 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding Phage_GP20 PF06810.11 ETO00595.1 - 0.63 9.8 12.4 0.18 11.6 6.0 2.4 1 1 2 3 3 3 0 Phage minor structural protein GP20 DUF3958 PF13125.6 ETO00595.1 - 0.64 10.2 10.9 1.7 8.9 6.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3958) SOAR PF16533.5 ETO00595.1 - 0.7 9.9 8.5 0.85 9.6 3.3 2.2 1 1 1 2 2 2 0 STIM1 Orai1-activating region TMPIT PF07851.13 ETO00595.1 - 0.9 8.7 7.8 1.2 8.3 7.3 1.5 1 1 1 2 2 2 0 TMPIT-like protein CLZ PF16526.5 ETO00595.1 - 1.2 9.5 10.1 0.69 10.3 2.7 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NPV_P10 PF05531.12 ETO00595.1 - 1.2 9.6 6.7 4 8.0 2.7 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein HBS1_N PF08938.10 ETO00595.1 - 2.4 8.5 7.3 0.7 10.2 1.7 2.3 1 1 1 2 2 2 0 HBS1 N-terminus YtxH PF12732.7 ETO00595.1 - 4.4 7.9 6.4 32 5.2 4.9 2.7 2 1 0 2 2 2 0 YtxH-like protein LemA PF04011.12 ETO00596.1 - 0.032 14.1 0.4 0.085 12.7 0.1 1.9 2 0 0 2 2 2 0 LemA family IL28A PF15177.6 ETO00596.1 - 0.046 13.6 0.7 0.11 12.3 0.2 1.9 2 0 0 2 2 2 0 Interleukin-28A CDC45 PF02724.14 ETO00597.1 - 8.9 4.5 15.4 12 4.0 15.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4028 PF13220.6 ETO00598.1 - 0.0059 16.4 6.8 0.013 15.3 6.8 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4028) Peptidase_S49_N PF08496.10 ETO00599.1 - 0.038 14.1 1.5 0.042 13.9 1.5 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal UPF0261 PF06792.11 ETO00599.1 - 0.04 12.9 0.5 0.062 12.2 0.2 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0261) DUF4484 PF14831.6 ETO00599.1 - 0.12 12.4 0.1 0.14 12.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) NusG PF02357.19 ETO00602.1 - 0.45 11.1 3.5 0.26 11.8 1.1 1.8 2 0 0 2 2 2 0 Transcription termination factor nusG zf-C2HE PF16278.5 ETO00603.1 - 0.27 11.7 11.2 1.8 9.1 1.8 2.7 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF1644 PF07800.12 ETO00603.1 - 0.61 10.1 12.0 5 7.2 12.0 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) Ank_3 PF13606.6 ETO00604.1 - 2.1e-09 36.8 0.6 0.00018 21.7 0.1 4.0 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 ETO00604.1 - 4.5e-08 33.6 0.5 3.1e-07 30.9 0.1 2.3 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO00604.1 - 1.9e-06 28.0 1.2 8.8e-06 25.9 0.2 2.4 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO00604.1 - 3.7e-05 24.2 1.9 0.0011 19.5 0.4 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO00604.1 - 0.00087 19.6 0.0 0.011 16.2 0.0 2.7 3 0 0 3 3 3 1 Ankyrin repeat Sacchrp_dh_NADP PF03435.18 ETO00604.1 - 0.051 13.8 0.0 0.074 13.3 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain DNA_pol_E_B PF04042.16 ETO00604.1 - 0.052 12.9 0.0 0.078 12.3 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B TPR_1 PF00515.28 ETO00605.1 - 4.7e-06 26.2 0.1 8.3e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00605.1 - 0.0017 18.4 0.0 0.0037 17.3 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00605.1 - 0.0023 17.8 0.0 0.0033 17.3 0.0 1.4 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00605.1 - 0.014 15.5 0.5 0.035 14.3 0.5 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO00605.1 - 0.017 15.4 0.0 0.028 14.7 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat MIT PF04212.18 ETO00605.1 - 0.019 15.0 0.1 0.025 14.6 0.1 1.3 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO00605.1 - 0.054 13.2 2.0 1.3 8.7 0.8 2.5 1 1 1 2 2 2 0 TPR repeat Kelch_6 PF13964.6 ETO00606.1 - 3.3e-06 27.2 2.1 0.015 15.6 0.3 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO00606.1 - 3.8e-06 26.4 1.3 0.00057 19.4 0.1 2.1 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO00606.1 - 0.0013 18.7 0.4 0.27 11.3 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO00606.1 - 0.0033 17.4 1.3 0.16 12.0 0.1 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain UL20 PF17582.2 ETO00607.1 - 0.0074 15.6 0.1 0.01 15.2 0.1 1.1 1 0 0 1 1 1 1 Cytomegalovirus UL20 putAbiC PF16872.5 ETO00607.1 - 0.44 11.3 5.3 3.7 8.3 5.3 2.2 1 1 0 1 1 1 0 Putative phage abortive infection protein DUF1542 PF07564.11 ETO00609.1 - 0.17 12.0 3.5 0.13 12.4 0.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1542) Lipl32 PF12103.8 ETO00609.1 - 0.17 11.5 1.8 0.37 10.4 1.8 1.4 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order Peptidase_C54 PF03416.19 ETO00614.1 - 0.088 12.2 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C54 WD40 PF00400.32 ETO00615.1 - 7.2e-08 33.0 0.7 1.4e-07 32.1 0.7 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO00615.1 - 8.5e-06 26.4 1.7 1.7e-05 25.4 1.7 1.6 1 0 0 1 1 1 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO00615.1 - 0.0049 17.1 0.1 0.023 15.0 0.0 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain SspO PF08175.12 ETO00615.1 - 0.033 14.6 2.1 0.033 14.6 2.1 3.0 3 0 0 3 3 3 0 Small acid-soluble spore protein O family FAM76 PF16046.5 ETO00615.1 - 2.5 7.4 34.0 1.6 8.0 32.1 1.6 1 1 0 1 1 1 0 FAM76 protein WD40 PF00400.32 ETO00617.1 - 3.9e-05 24.3 2.7 5.1e-05 24.0 0.6 2.2 2 2 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO00617.1 - 0.17 10.5 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Potex_coat PF06184.11 ETO00617.1 - 0.18 11.4 0.0 0.21 11.1 0.0 1.1 1 0 0 1 1 1 0 Potexvirus coat protein DUF2607 PF10795.9 ETO00619.1 - 0.064 13.4 0.5 5.9 7.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2607) zf-RING-like PF08746.11 ETO00619.1 - 0.27 11.6 5.0 0.39 11.1 0.5 2.8 1 1 1 2 2 2 0 RING-like domain zf-C3HC4_3 PF13920.6 ETO00619.1 - 0.75 9.7 4.8 4.4 7.2 4.8 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO00619.1 - 2.6 8.5 8.0 0.63 10.4 3.0 2.6 2 1 1 3 3 3 0 Ring finger domain DUF4407 PF14362.6 ETO00621.1 - 2.5 7.4 12.6 3 7.1 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) fn3 PF00041.21 ETO00622.1 - 0.00015 22.0 0.0 0.00097 19.4 0.0 2.2 2 0 0 2 2 2 1 Fibronectin type III domain Atrophin-1 PF03154.15 ETO00622.1 - 0.011 14.1 6.1 0.015 13.7 6.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family CENP-B_dimeris PF09026.10 ETO00622.1 - 0.011 16.0 3.8 0.02 15.3 3.8 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RPA43_OB PF17875.1 ETO00622.1 - 0.11 13.2 1.8 0.15 12.7 1.8 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DUF3915 PF13054.6 ETO00622.1 - 0.14 12.1 4.0 0.3 11.1 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Pur_ac_phosph_N PF16656.5 ETO00622.1 - 0.15 12.7 0.1 0.47 11.0 0.1 1.8 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain CDC45 PF02724.14 ETO00622.1 - 0.16 10.3 5.4 0.16 10.2 5.4 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETO00622.1 - 1.5 8.5 6.1 2.5 7.8 6.1 1.3 1 0 0 1 1 1 0 FAM176 family Pes-10 PF07149.11 ETO00622.1 - 1.6 7.7 7.0 2.8 6.9 7.0 1.3 1 0 0 1 1 1 0 Pes-10 DUF2987 PF11205.8 ETO00624.1 - 0.057 13.3 1.0 4.5 7.2 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2987) Tir_receptor_N PF07490.11 ETO00624.1 - 0.24 11.2 1.1 0.3 10.9 1.1 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus BOFC_N PF08977.10 ETO00624.1 - 0.38 10.8 2.3 8.3 6.5 0.2 2.4 2 0 0 2 2 2 0 Bypass of Forespore C, N terminal RNase_H PF00075.24 ETO00626.1 - 6.1e-11 42.7 0.0 1.6e-10 41.3 0.0 1.6 1 1 0 1 1 1 1 RNase H WD40 PF00400.32 ETO00627.1 - 5.5e-13 49.2 3.9 7e-06 26.7 1.9 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00627.1 - 7.4e-05 23.0 0.0 0.0046 17.2 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00627.1 - 0.0018 17.0 0.4 0.12 10.9 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 FUSC PF04632.12 ETO00628.1 - 0.053 12.1 1.3 0.06 11.9 0.3 1.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family DASH_Dad1 PF08649.10 ETO00628.1 - 2.2 8.6 14.2 2.3 8.5 0.2 6.0 6 0 0 6 6 6 0 DASH complex subunit Dad1 Kelch_5 PF13854.6 ETO00629.1 - 0.11 12.6 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Kelch motif DUF2052 PF09747.9 ETO00630.1 - 0.014 15.5 14.5 0.015 15.5 14.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 ETO00630.1 - 0.019 14.4 14.3 0.019 14.4 14.3 1.0 1 0 0 1 1 1 0 SDA1 RPN2_C PF18004.1 ETO00630.1 - 0.048 13.6 10.5 0.053 13.4 10.5 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 ETO00630.1 - 0.076 11.1 18.7 0.083 11.0 18.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi CPSF100_C PF13299.6 ETO00630.1 - 0.078 13.2 7.8 0.09 13.0 7.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 ETO00630.1 - 0.1 12.7 2.2 0.11 12.6 2.2 1.1 1 0 0 1 1 1 0 DDHD domain Eapp_C PF10238.9 ETO00630.1 - 0.13 12.4 3.3 0.13 12.3 3.3 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Nop14 PF04147.12 ETO00630.1 - 0.13 10.4 16.0 0.12 10.5 16.0 1.0 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 ETO00630.1 - 0.2 11.3 25.2 0.25 11.0 25.2 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) TEX19 PF15553.6 ETO00630.1 - 0.23 11.4 8.9 0.28 11.1 8.9 1.1 1 0 0 1 1 1 0 Testis-expressed protein 19 Tim54 PF11711.8 ETO00630.1 - 0.23 10.2 8.1 0.21 10.3 8.1 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AIF_C PF14721.6 ETO00630.1 - 0.3 11.4 3.3 0.36 11.2 3.3 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RNA_pol_Rpc4 PF05132.14 ETO00630.1 - 0.3 11.5 6.1 0.35 11.3 6.1 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 XAP5 PF04921.14 ETO00630.1 - 0.33 10.7 7.0 0.3 10.9 7.0 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF3306 PF11748.8 ETO00630.1 - 0.34 11.8 9.5 0.35 11.7 9.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DUF3464 PF11947.8 ETO00630.1 - 0.4 10.4 3.2 0.4 10.4 3.2 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 RPA43_OB PF17875.1 ETO00630.1 - 0.4 11.3 6.8 0.43 11.2 6.8 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I PI3K_1B_p101 PF10486.9 ETO00630.1 - 0.42 8.3 6.0 0.39 8.4 6.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit EIIBC-GUT_N PF03612.14 ETO00630.1 - 0.45 10.2 4.8 0.46 10.2 4.8 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 ETO00630.1 - 0.53 9.0 5.8 0.55 9.0 5.8 1.0 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 ETO00630.1 - 0.61 9.4 15.7 0.71 9.2 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SpoIIP PF07454.11 ETO00630.1 - 0.71 9.3 10.2 0.76 9.2 10.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Sec62 PF03839.16 ETO00630.1 - 0.82 9.1 3.7 0.78 9.2 3.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Vfa1 PF08432.10 ETO00630.1 - 0.93 9.8 9.8 0.97 9.7 9.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NARP1 PF12569.8 ETO00630.1 - 1.1 8.1 8.5 1.3 7.9 8.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 FAM176 PF14851.6 ETO00630.1 - 1.2 8.8 14.7 1.5 8.4 14.7 1.1 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ETO00630.1 - 1.2 7.4 14.1 1.2 7.4 14.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO00630.1 - 1.2 8.9 5.6 1.3 8.8 5.6 1.1 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 ETO00630.1 - 1.2 8.0 5.9 1.3 7.9 5.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO00630.1 - 1.2 7.8 5.0 1.1 7.9 5.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CLN3 PF02487.17 ETO00630.1 - 1.6 7.7 4.1 1.8 7.5 4.1 1.0 1 0 0 1 1 1 0 CLN3 protein DUF3530 PF12048.8 ETO00630.1 - 1.8 7.9 8.5 2.4 7.5 8.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) Zip PF02535.22 ETO00630.1 - 2.2 7.4 3.4 2 7.6 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Gag_p12 PF01141.18 ETO00630.1 - 2.3 8.6 4.8 0.53 10.7 0.3 1.9 1 1 1 2 2 1 0 Gag polyprotein, inner coat protein p12 Pox_Ag35 PF03286.14 ETO00630.1 - 2.6 7.8 14.9 3.2 7.5 14.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RRN3 PF05327.11 ETO00630.1 - 2.8 6.4 9.8 2.5 6.5 9.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cytomega_UL84 PF06284.11 ETO00630.1 - 2.9 6.3 11.8 3 6.2 11.8 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein HSP90 PF00183.18 ETO00630.1 - 3.3 6.5 16.5 3.4 6.5 16.5 1.1 1 0 0 1 1 1 0 Hsp90 protein DUF4637 PF15470.6 ETO00630.1 - 4.2 7.1 19.9 5.7 6.6 19.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RR_TM4-6 PF06459.12 ETO00630.1 - 4.7 6.9 15.2 5.1 6.8 15.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2722 PF10846.8 ETO00630.1 - 5.1 5.9 10.2 5.5 5.8 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Afi1 PF07792.12 ETO00630.1 - 5.3 7.5 10.2 6.5 7.2 10.2 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CobT PF06213.12 ETO00630.1 - 5.6 6.3 20.7 8.2 5.7 20.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sporozoite_P67 PF05642.11 ETO00630.1 - 6.2 4.8 10.5 6.8 4.7 10.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.6 ETO00630.1 - 6.6 7.2 9.2 10 6.6 9.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Myco_haema PF05692.12 ETO00630.1 - 6.8 5.6 5.6 7.2 5.5 5.6 1.1 1 0 0 1 1 1 0 Mycoplasma haemagglutinin Usp PF00582.26 ETO00630.1 - 7 7.2 12.4 10 6.6 12.4 1.2 1 0 0 1 1 1 0 Universal stress protein family TRAP_alpha PF03896.16 ETO00630.1 - 7.5 5.7 13.6 8.1 5.6 13.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Fmp27 PF10344.9 ETO00630.1 - 8.8 4.3 10.7 9.5 4.2 10.7 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 V_ATPase_I PF01496.19 ETO00630.1 - 9.7 4.0 8.5 10 3.9 8.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WD40 PF00400.32 ETO00632.1 - 4.7e-15 55.7 10.7 0.00044 21.0 0.2 5.0 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO00632.1 - 2.4e-06 26.5 1.0 0.11 11.1 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00632.1 - 0.00038 20.7 0.1 0.55 10.6 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain KduI PF04962.12 ETO00632.1 - 0.068 12.5 0.0 0.084 12.2 0.0 1.1 1 0 0 1 1 1 0 KduI/IolB family NACHT PF05729.12 ETO00633.1 - 1.8e-09 37.8 0.0 2.1e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO00633.1 - 0.00015 22.1 0.1 0.00061 20.1 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO00633.1 - 0.00017 22.1 1.3 0.00028 21.4 0.0 1.9 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ETO00633.1 - 0.0034 17.8 0.5 0.026 14.9 0.2 2.4 1 1 0 1 1 1 1 RNA helicase ATP_bind_2 PF03668.15 ETO00633.1 - 0.0052 16.1 0.0 0.0071 15.7 0.0 1.2 1 0 0 1 1 1 1 P-loop ATPase protein family DUF2075 PF09848.9 ETO00633.1 - 0.0088 15.3 0.1 0.0088 15.3 0.1 1.8 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 ETO00633.1 - 0.0091 16.5 0.6 0.016 15.7 0.4 1.6 1 1 0 1 1 1 1 ABC transporter Zeta_toxin PF06414.12 ETO00633.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.4 1 1 0 1 1 1 0 Zeta toxin RsgA_GTPase PF03193.16 ETO00633.1 - 0.014 15.3 1.2 0.021 14.8 0.9 1.5 1 1 0 1 1 1 0 RsgA GTPase AAA_7 PF12775.7 ETO00633.1 - 0.015 14.8 0.1 0.023 14.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 ETO00633.1 - 0.016 14.6 0.2 0.02 14.3 0.2 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 ETO00633.1 - 0.02 14.6 0.1 0.038 13.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ETO00633.1 - 0.022 15.2 0.8 0.15 12.5 0.1 2.4 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETO00633.1 - 0.03 14.0 0.0 0.048 13.4 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 ETO00633.1 - 0.032 14.7 0.0 0.053 13.9 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ETO00633.1 - 0.037 13.4 0.4 0.084 12.2 0.1 1.8 1 1 1 2 2 2 0 KaiC AAA_30 PF13604.6 ETO00633.1 - 0.042 13.6 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO00633.1 - 0.045 13.9 0.0 0.1 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO00633.1 - 0.05 13.4 0.1 0.099 12.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO00633.1 - 0.074 13.4 0.0 0.1 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ABC_export PF16962.5 ETO00633.1 - 0.084 11.3 0.1 0.097 11.1 0.1 1.1 1 0 0 1 1 1 0 Putative ABC exporter TsaE PF02367.17 ETO00633.1 - 0.092 12.8 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 ETO00633.1 - 0.28 11.2 3.8 0.07 13.2 0.8 1.6 2 1 0 2 2 1 0 AAA domain Peptidase_S49_N PF08496.10 ETO00633.1 - 0.3 11.1 3.2 0.59 10.2 3.2 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF1163 PF06651.11 ETO00633.1 - 0.5 10.5 3.3 4.7 7.4 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1163) Eaf7 PF07904.13 ETO00633.1 - 4.5 7.7 11.1 0.67 10.4 0.5 2.2 1 1 0 2 2 2 0 Chromatin modification-related protein EAF7 RasGAP_C PF03836.15 ETO00635.1 - 0.023 14.8 0.4 0.097 12.8 0.1 2.1 2 0 0 2 2 2 0 RasGAP C-terminus Kelch_1 PF01344.25 ETO00636.1 - 9.2e-12 44.4 1.2 2.4e-07 30.2 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO00636.1 - 3.4e-09 36.3 0.5 7.9e-06 25.6 0.2 2.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO00636.1 - 3.4e-08 33.5 0.1 0.002 18.3 0.2 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO00636.1 - 1.2e-07 31.7 0.3 0.00038 20.4 0.2 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00636.1 - 5.8e-07 29.4 0.0 0.00079 19.4 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO00636.1 - 2.1e-06 27.9 0.7 0.00018 21.7 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain SCF PF02404.15 ETO00640.1 - 0.0023 17.3 1.9 0.014 14.7 0.4 2.1 2 0 0 2 2 2 2 Stem cell factor U-box PF04564.15 ETO00642.1 - 1.5e-11 44.3 0.0 3.3e-11 43.2 0.0 1.6 1 1 0 1 1 1 1 U-box domain SAM_1 PF00536.30 ETO00642.1 - 0.02 15.3 0.2 0.048 14.1 0.2 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2124 PF09897.9 ETO00642.1 - 0.1 12.5 0.4 0.15 11.9 0.4 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2124) Beta_helix PF13229.6 ETO00643.1 - 0.033 14.0 13.1 0.037 13.9 10.5 1.7 1 1 0 1 1 1 0 Right handed beta helix region WD40 PF00400.32 ETO00647.1 - 2.1e-16 60.0 1.4 1.8e-05 25.4 0.0 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO00647.1 - 0.0037 17.3 0.4 1 9.4 0.0 2.3 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ETO00647.1 - 0.015 14.0 0.1 1.8 7.1 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Ribosomal_L6e PF01159.19 ETO00650.1 - 0.22 12.1 15.7 0.26 11.9 15.7 1.0 1 0 0 1 1 1 0 Ribosomal protein L6e AP3D1 PF06375.11 ETO00650.1 - 0.63 10.3 21.6 0.7 10.1 21.6 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Vfa1 PF08432.10 ETO00650.1 - 0.94 9.8 17.1 0.94 9.8 17.1 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1764 PF08576.10 ETO00650.1 - 1.1 10.2 15.3 1.1 10.2 15.3 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) SR-25 PF10500.9 ETO00650.1 - 1.2 8.7 29.1 1.3 8.6 29.1 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3464 PF11947.8 ETO00650.1 - 1.2 8.8 12.6 1.2 8.9 12.6 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Ribosomal_S25 PF03297.15 ETO00650.1 - 1.5 9.1 24.3 1.6 9.0 24.3 1.1 1 0 0 1 1 1 0 S25 ribosomal protein Ferlin_C PF16165.5 ETO00650.1 - 1.5 8.7 15.8 1.7 8.6 15.8 1.1 1 0 0 1 1 1 0 Ferlin C-terminus EIIBC-GUT_N PF03612.14 ETO00650.1 - 2 8.1 7.9 2 8.1 7.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Eapp_C PF10238.9 ETO00650.1 - 2.4 8.2 9.5 2.4 8.2 9.5 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein DNApol_Exo PF18136.1 ETO00650.1 - 2.5 7.2 7.8 2.4 7.2 7.8 1.0 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF2956 PF11169.8 ETO00650.1 - 2.6 8.3 17.0 2.8 8.2 17.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Connexin PF00029.19 ETO00650.1 - 3 7.5 10.1 2.9 7.6 10.1 1.0 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 ETO00650.1 - 3.7 7.0 14.6 3.9 6.9 14.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 CMS1 PF14617.6 ETO00650.1 - 5 6.4 17.1 5.3 6.3 17.1 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit PPL5 PF18168.1 ETO00650.1 - 5.7 6.1 11.0 5.7 6.1 11.0 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Folate_carrier PF01770.18 ETO00650.1 - 7 5.3 5.3 6.8 5.3 5.3 1.0 1 0 0 1 1 1 0 Reduced folate carrier Peroxin-13_N PF04088.13 ETO00650.1 - 7.2 6.9 6.5 7.5 6.8 6.5 1.0 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Presenilin PF01080.17 ETO00650.1 - 7.5 5.2 6.2 7.5 5.2 6.2 1.0 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.8 ETO00650.1 - 9 6.2 6.1 8.8 6.2 6.1 1.1 1 0 0 1 1 1 0 N-glycosylation protein DUF4482 PF14818.6 ETO00651.1 - 0.016 16.1 2.0 0.041 14.7 2.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) U3_assoc_6 PF08640.11 ETO00651.1 - 0.059 13.4 1.3 0.11 12.6 0.1 1.9 2 0 0 2 2 2 0 U3 small nucleolar RNA-associated protein 6 NACHT PF05729.12 ETO00652.1 - 3.4e-13 49.8 0.0 5.5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO00652.1 - 3.3e-05 23.2 0.1 7e-05 22.1 0.1 1.6 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ETO00652.1 - 0.0012 19.3 0.0 0.0039 17.6 0.0 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO00652.1 - 0.0017 18.6 0.2 0.015 15.5 0.0 2.4 2 2 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ETO00652.1 - 0.0038 17.6 0.2 0.56 10.6 0.0 3.2 3 0 0 3 3 3 1 RNA helicase AAA_30 PF13604.6 ETO00652.1 - 0.074 12.8 0.0 0.42 10.3 0.0 2.0 1 1 1 2 2 2 0 AAA domain Torsin PF06309.11 ETO00652.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.5 1 0 0 1 1 1 0 Torsin Enkurin PF13864.6 ETO00653.1 - 0.77 10.2 14.0 3.6 8.1 0.4 4.0 3 0 0 3 3 3 0 Calmodulin-binding SPG4 PF17325.2 ETO00653.1 - 0.88 10.7 5.3 6.8 7.8 5.7 2.3 2 0 0 2 2 2 0 Stationary phase protein 4 AAA_5 PF07728.14 ETO00654.1 - 2.2e-05 24.4 0.0 6.5e-05 22.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 ETO00654.1 - 3e-05 23.5 0.0 6.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA PF00004.29 ETO00654.1 - 6.2e-05 23.4 0.0 0.00025 21.5 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ETO00654.1 - 0.00011 22.2 0.0 0.0011 19.0 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETO00654.1 - 0.00016 21.2 0.0 0.00063 19.3 0.0 2.0 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF815 PF05673.13 ETO00654.1 - 0.00021 20.6 0.2 0.00042 19.6 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO00654.1 - 0.00045 20.7 0.2 0.0017 18.9 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ETO00654.1 - 0.0063 16.9 0.0 0.042 14.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETO00654.1 - 0.0075 16.5 0.2 0.051 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain MCM PF00493.23 ETO00654.1 - 0.0096 15.0 0.1 0.052 12.6 0.0 2.2 3 0 0 3 3 3 1 MCM P-loop domain Sigma54_activat PF00158.26 ETO00654.1 - 0.018 14.8 0.0 0.2 11.3 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETO00654.1 - 0.019 15.3 0.1 0.093 13.1 0.0 2.3 2 0 0 2 2 1 0 RNA helicase AAA_2 PF07724.14 ETO00654.1 - 0.062 13.4 0.1 0.23 11.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) ATPase_2 PF01637.18 ETO00654.1 - 0.069 13.0 0.1 0.3 11.0 0.0 2.2 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ETO00654.1 - 0.099 12.7 0.3 0.31 11.1 0.0 2.0 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TMEM247 PF15444.6 ETO00660.1 - 0.042 13.9 0.7 0.066 13.3 0.7 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 zf-CCHC PF00098.23 ETO00661.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.7 3 0 0 3 3 3 0 Zinc knuckle LRR_5 PF13306.6 ETO00664.1 - 0.0043 17.0 3.7 0.017 15.1 3.7 1.8 1 1 0 1 1 1 1 BspA type Leucine rich repeat region (6 copies) DUF913 PF06025.12 ETO00665.1 - 0.028 13.4 7.9 0.038 13.0 7.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 ETO00665.1 - 0.043 12.1 14.6 0.052 11.8 14.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO00665.1 - 0.25 9.5 20.5 0.31 9.2 20.5 1.1 1 0 0 1 1 1 0 Nop14-like family CCDC106 PF15794.5 ETO00665.1 - 0.72 9.5 12.3 1.1 8.9 12.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Zip PF02535.22 ETO00665.1 - 1.6 7.8 9.3 2 7.6 9.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO00665.1 - 2.1 8.3 5.1 2.7 8.0 5.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 ETO00665.1 - 4.2 6.7 14.2 6.9 6.0 14.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4519 PF15012.6 ETO00665.1 - 4.3 7.6 8.5 0.37 11.0 3.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Hid1 PF12722.7 ETO00665.1 - 4.6 5.3 10.7 5.1 5.1 10.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRN3 PF05327.11 ETO00665.1 - 6.1 5.3 13.4 7.9 4.9 13.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Presenilin PF01080.17 ETO00665.1 - 8.1 5.1 12.4 9.6 4.9 12.4 1.1 1 0 0 1 1 1 0 Presenilin Flavodoxin_4 PF12682.7 ETO00667.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.3 1 0 0 1 1 1 0 Flavodoxin Tho2 PF11262.8 ETO00669.1 - 0.0018 17.5 0.2 0.0031 16.8 0.2 1.3 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 CREPT PF16566.5 ETO00669.1 - 0.05 13.8 0.4 0.48 10.6 0.1 2.2 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Gpi1 PF05024.15 ETO00669.1 - 0.081 13.0 0.2 0.18 11.9 0.1 1.6 1 1 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) RdgC PF04381.12 ETO00670.1 - 0.034 13.4 1.8 0.087 12.1 0.4 1.9 2 0 0 2 2 2 0 Putative exonuclease, RdgC HSP90 PF00183.18 ETO00671.1 - 1.1e-64 219.3 14.6 2.3e-62 211.6 14.6 2.0 1 1 0 1 1 1 1 Hsp90 protein NAT PF04768.13 ETO00671.1 - 0.0066 16.1 0.2 0.011 15.4 0.2 1.5 1 0 0 1 1 1 1 NAT, N-acetyltransferase, of N-acetylglutamate synthase PilN PF05137.13 ETO00671.1 - 0.014 15.5 0.0 0.037 14.2 0.0 1.7 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) HATPase_c PF02518.26 ETO00672.1 - 0.1 13.1 0.0 0.16 12.5 0.0 1.3 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Mss4 PF04421.13 ETO00672.1 - 0.4 10.9 3.4 0.49 10.6 2.1 1.6 1 1 1 2 2 2 0 Mss4 protein Golgin_A5 PF09787.9 ETO00676.1 - 3.3e-05 23.5 25.3 0.0013 18.3 13.4 2.0 1 1 1 2 2 2 2 Golgin subfamily A member 5 EzrA PF06160.12 ETO00676.1 - 0.00015 20.1 24.1 0.00024 19.4 12.5 2.0 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA WEMBL PF05701.11 ETO00676.1 - 0.00022 20.1 30.3 0.00038 19.3 30.3 1.4 1 1 0 1 1 1 1 Weak chloroplast movement under blue light HIP1_clath_bdg PF16515.5 ETO00676.1 - 0.00049 20.7 29.1 0.009 16.6 7.1 3.1 1 1 2 3 3 3 2 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2524 PF10732.9 ETO00676.1 - 0.013 15.7 15.3 0.34 11.2 3.2 3.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2524) Spc7 PF08317.11 ETO00676.1 - 0.021 13.7 33.2 0.28 10.0 8.9 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Filament PF00038.21 ETO00676.1 - 0.03 13.9 24.7 0.31 10.6 10.5 2.2 1 1 1 2 2 2 0 Intermediate filament protein HMMR_N PF15905.5 ETO00676.1 - 0.032 13.7 32.4 0.056 12.9 32.4 1.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FlaC_arch PF05377.11 ETO00676.1 - 0.038 14.4 22.0 2.3 8.7 0.9 4.0 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.11 ETO00676.1 - 0.041 12.8 27.4 0.013 14.4 14.8 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like GAS PF13851.6 ETO00676.1 - 0.043 13.2 32.5 0.059 12.7 9.2 2.6 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ETO00676.1 - 0.065 13.8 38.5 2.2 8.8 17.9 2.8 1 1 2 3 3 3 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 ETO00676.1 - 0.073 13.1 35.9 0.054 13.5 10.7 2.9 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 ETO00676.1 - 0.079 13.2 31.5 0.13 12.5 15.3 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Sharpin_PH PF16764.5 ETO00676.1 - 0.086 12.6 1.5 0.14 11.9 1.2 1.6 1 1 0 1 1 1 0 Sharpin PH domain Fez1 PF06818.15 ETO00676.1 - 0.12 12.8 29.1 0.61 10.5 14.2 2.0 1 1 1 2 2 2 0 Fez1 APG17 PF04108.12 ETO00676.1 - 0.13 11.3 17.3 0.038 13.1 6.2 2.1 1 1 1 2 2 2 0 Autophagy protein Apg17 TPR_MLP1_2 PF07926.12 ETO00676.1 - 0.17 12.0 33.6 3.7 7.6 16.9 3.0 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DLP_helical PF18709.1 ETO00676.1 - 0.24 10.6 21.6 0.41 9.8 2.3 3.0 1 1 1 3 3 3 0 Dynamin-like helical domain Sec8_exocyst PF04048.14 ETO00676.1 - 0.25 11.2 18.1 1.6 8.6 2.1 3.1 1 1 2 3 3 3 0 Sec8 exocyst complex component specific domain SLATT_6 PF18169.1 ETO00676.1 - 0.43 10.2 10.2 0.07 12.7 1.7 2.3 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 PRKG1_interact PF15898.5 ETO00676.1 - 0.49 11.3 30.0 7.6 7.5 14.2 3.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain TolA_bind_tri PF16331.5 ETO00676.1 - 0.56 10.3 7.7 9.8 6.3 0.2 2.7 2 1 0 2 2 2 0 TolA binding protein trimerisation Seryl_tRNA_N PF02403.22 ETO00676.1 - 0.68 10.2 29.8 0.94 9.7 13.6 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain YscO-like PF16789.5 ETO00676.1 - 0.76 9.8 31.4 3.9 7.5 6.4 3.4 1 1 3 4 4 4 0 YscO-like protein DegS PF05384.11 ETO00676.1 - 0.82 9.1 23.4 1.5 8.3 5.9 3.0 1 1 2 3 3 3 0 Sensor protein DegS DUF3584 PF12128.8 ETO00676.1 - 0.88 7.0 25.2 0.18 9.3 2.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) ADIP PF11559.8 ETO00676.1 - 0.94 9.6 31.6 0.36 10.9 10.3 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Vps5 PF09325.10 ETO00676.1 - 1.6 8.2 23.0 1.9 8.0 7.8 2.3 1 1 1 2 2 2 0 Vps5 C terminal like DUF1664 PF07889.12 ETO00676.1 - 1.6 8.8 16.8 7.9 6.5 2.3 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 ETO00676.1 - 1.8 8.3 19.7 9.3 5.9 13.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Laminin_II PF06009.12 ETO00676.1 - 1.8 8.5 18.6 40 4.2 12.2 2.7 1 1 1 2 2 2 0 Laminin Domain II ERM PF00769.19 ETO00676.1 - 2 8.2 35.1 0.26 11.1 24.9 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DHR10 PF18595.1 ETO00676.1 - 2.5 8.2 34.1 1.5 8.9 5.9 3.1 1 1 2 3 3 3 0 Designed helical repeat protein 10 domain YgaB PF14182.6 ETO00676.1 - 3.5 8.1 23.3 17 5.9 3.1 4.0 1 1 2 4 4 4 0 YgaB-like protein TMEM247 PF15444.6 ETO00676.1 - 4.3 7.3 18.9 5.9 6.9 5.9 3.1 1 1 2 3 3 3 0 Transmembrane protein 247 Ntox28 PF15605.6 ETO00676.1 - 5.7 7.2 15.6 0.77 10.0 2.7 3.0 2 1 1 3 3 3 0 Bacterial toxin 28 DUF4201 PF13870.6 ETO00676.1 - 5.8 6.6 30.7 8.4 6.1 7.9 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) DUF4472 PF14739.6 ETO00676.1 - 6.1 7.6 27.0 9.6 7.0 14.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) DUF3450 PF11932.8 ETO00676.1 - 8.2 5.7 21.9 5.1 6.3 8.1 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) H-kinase_dim PF02895.14 ETO00676.1 - 9.1 6.8 14.6 15 6.0 1.9 3.5 1 1 1 2 2 2 0 Signal transducing histidine kinase, homodimeric domain Glyco_hydro_2 PF00703.21 ETO00676.1 - 9.1 7.0 14.2 5.1 7.8 4.6 2.2 1 1 1 2 2 2 0 Glycosyl hydrolases family 2 LMBR1 PF04791.16 ETO00676.1 - 9.9 4.9 21.4 20 3.9 21.4 1.5 1 1 0 1 1 1 0 LMBR1-like membrane protein TLD PF07534.16 ETO00678.1 - 3.9e-12 46.6 0.7 7.9e-12 45.6 0.7 1.5 1 0 0 1 1 1 1 TLD ART PF01129.18 ETO00678.1 - 0.024 13.9 0.0 0.044 13.1 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase Fimbrial_PilY2 PF14481.6 ETO00678.1 - 0.12 12.0 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Type 4 fimbrial biogenesis protein PilY2 Tubulin_C PF03953.17 ETO00679.1 - 7e-29 100.6 0.0 9.6e-29 100.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO00679.1 - 9.7e-08 32.4 0.0 1.7e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain tRNA-synt_1c_C PF03950.18 ETO00679.1 - 0.013 15.4 0.0 0.019 14.8 0.0 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain TPR_12 PF13424.6 ETO00680.1 - 1.9e-47 159.4 7.9 1.7e-20 73.1 0.2 3.6 3 1 1 4 4 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00680.1 - 2.7e-37 125.6 3.5 1e-08 34.7 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00680.1 - 2.1e-32 108.8 5.3 1.6e-07 30.8 0.0 4.8 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00680.1 - 2.6e-31 106.1 36.6 1.9e-08 33.7 1.9 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00680.1 - 1e-24 84.6 29.5 6.7e-07 29.0 1.2 4.9 6 0 0 6 6 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00680.1 - 4e-21 73.4 20.7 3.4e-05 23.6 0.6 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00680.1 - 3.5e-14 52.1 10.3 0.0059 16.9 0.2 5.9 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00680.1 - 4.3e-12 46.5 0.0 0.1 13.3 0.0 5.2 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00680.1 - 7.8e-10 38.7 3.2 0.02 15.5 0.2 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00680.1 - 2e-09 37.5 0.0 2.3 9.2 0.0 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO00680.1 - 1.5e-08 34.7 12.8 0.028 14.2 0.3 4.2 4 0 0 4 4 4 4 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO00680.1 - 4.3e-07 29.8 24.5 0.032 14.2 0.1 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat RPN7 PF10602.9 ETO00680.1 - 1e-06 28.6 6.4 0.0049 16.6 0.1 3.3 1 1 2 3 3 3 2 26S proteasome subunit RPN7 SNAP PF14938.6 ETO00680.1 - 1.8e-06 27.6 6.4 0.0014 18.1 1.9 2.6 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_MalT PF17874.1 ETO00680.1 - 9.5e-06 25.2 0.0 2.8e-05 23.7 0.0 1.6 1 1 0 1 1 1 1 MalT-like TPR region TPR_11 PF13414.6 ETO00680.1 - 9e-05 22.1 40.0 0.1 12.3 2.4 8.0 7 3 3 10 10 9 4 TPR repeat ANAPC3 PF12895.7 ETO00680.1 - 0.0002 21.5 11.1 0.013 15.8 0.7 4.6 1 1 4 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF627 PF04781.12 ETO00680.1 - 0.00044 20.2 1.9 2 8.4 0.1 3.5 2 1 2 4 4 4 1 Protein of unknown function (DUF627) PPR PF01535.20 ETO00680.1 - 0.00085 19.4 10.6 1.2 9.6 0.3 5.4 5 0 0 5 5 5 1 PPR repeat TPR_19 PF14559.6 ETO00680.1 - 0.004 17.6 1.0 3.6 8.2 0.1 3.9 2 1 2 4 4 4 1 Tetratricopeptide repeat OrfA PF17495.2 ETO00680.1 - 0.007 16.5 0.1 6.5 7.0 0.0 3.7 1 1 4 5 5 5 0 Vpr-like OrfA UPF0223 PF05256.12 ETO00680.1 - 0.012 15.9 4.4 3.3 8.1 0.1 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0223) MIT PF04212.18 ETO00680.1 - 0.026 14.6 18.4 3.3 7.9 0.2 4.6 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain YecM PF06185.12 ETO00680.1 - 0.033 13.8 0.6 20 4.8 0.0 3.5 1 1 3 4 4 4 0 YecM protein DUF4810 PF16068.5 ETO00680.1 - 0.053 14.1 5.9 1.9 9.1 1.3 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4810) HTH_Bact PF18768.1 ETO00680.1 - 0.096 12.3 7.3 13 5.4 0.0 4.5 4 1 0 4 4 4 0 Helix-turn-helix bacterial domain DUF3450 PF11932.8 ETO00680.1 - 0.12 11.7 7.5 6 6.1 0.1 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) DUF3856 PF12968.7 ETO00680.1 - 0.14 12.2 1.3 31 4.6 0.1 3.2 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) DUF2225 PF09986.9 ETO00680.1 - 0.24 11.1 8.5 0.57 9.9 2.1 2.7 1 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TetR_C_19 PF17924.1 ETO00680.1 - 0.33 11.6 6.6 13 6.5 0.1 3.9 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Mob_Pre PF01076.19 ETO00680.1 - 0.81 9.5 8.2 0.17 11.7 1.4 2.1 1 1 1 2 2 2 0 Plasmid recombination enzyme Sel1 PF08238.12 ETO00680.1 - 0.84 10.4 13.8 27 5.6 0.3 5.8 5 3 0 5 5 4 0 Sel1 repeat SPAN-X PF07458.12 ETO00680.1 - 2 8.9 4.0 37 4.8 0.2 3.3 3 1 1 4 4 3 0 Sperm protein associated with nucleus, mapped to X chromosome Peripla_BP_7 PF18610.1 ETO00680.1 - 2.1 8.6 9.8 1.2 9.3 1.8 3.0 2 1 1 3 3 3 0 Periplasmic binding protein domain TPR_12 PF13424.6 ETO00681.1 - 1.4e-45 153.4 6.3 1.1e-20 73.7 0.3 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00681.1 - 1e-37 127.0 0.5 1.7e-09 37.2 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00681.1 - 1.3e-34 115.6 4.4 6.2e-09 35.3 0.1 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00681.1 - 7.9e-30 101.5 29.6 4.3e-09 35.8 2.6 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00681.1 - 5.7e-24 82.3 16.8 1e-07 31.5 0.8 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00681.1 - 3.4e-23 79.9 26.6 6.6e-08 32.2 1.8 4.6 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00681.1 - 2.6e-13 49.3 10.0 0.00065 19.9 0.1 5.5 4 1 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00681.1 - 1.7e-10 41.4 0.0 0.005 17.5 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00681.1 - 5.9e-09 36.0 1.5 0.21 12.3 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00681.1 - 4.2e-08 33.4 0.0 1.1 10.3 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO00681.1 - 1.2e-06 28.4 10.8 0.12 12.2 0.2 3.9 4 0 0 4 4 4 3 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO00681.1 - 2.2e-06 27.2 32.1 0.018 14.7 2.2 6.9 6 2 1 7 7 7 4 TPR repeat RPN7 PF10602.9 ETO00681.1 - 2.9e-06 27.1 8.1 0.016 14.9 0.5 3.8 1 1 3 4 4 4 2 26S proteasome subunit RPN7 TPR_3 PF07720.12 ETO00681.1 - 3.5e-06 26.9 15.7 0.14 12.2 0.4 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat PPR PF01535.20 ETO00681.1 - 7.4e-06 25.9 7.4 0.099 12.9 0.2 4.3 4 0 0 4 4 4 1 PPR repeat SNAP PF14938.6 ETO00681.1 - 4.5e-05 23.0 7.6 0.019 14.4 0.7 2.9 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP OrfA PF17495.2 ETO00681.1 - 0.00011 22.4 0.0 1.9 8.7 0.0 3.0 1 1 2 3 3 3 2 Vpr-like OrfA TPR_19 PF14559.6 ETO00681.1 - 0.00056 20.4 0.3 0.077 13.5 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF627 PF04781.12 ETO00681.1 - 0.0026 17.8 0.9 0.4 10.7 0.6 2.9 1 1 1 2 2 2 1 Protein of unknown function (DUF627) TPR_MalT PF17874.1 ETO00681.1 - 0.0028 17.1 0.0 0.14 11.5 0.0 1.9 1 1 1 2 2 2 2 MalT-like TPR region YecM PF06185.12 ETO00681.1 - 0.0031 17.2 0.3 4.9 6.8 0.0 3.6 1 1 3 4 4 4 0 YecM protein TPR_5 PF12688.7 ETO00681.1 - 0.0039 17.4 0.0 18 5.6 0.0 3.6 1 1 3 4 4 4 0 Tetratrico peptide repeat ILEI PF15711.5 ETO00681.1 - 0.0057 17.1 0.2 9.8 6.7 0.0 3.3 4 0 0 4 4 3 0 Interleukin-like EMT inducer HTH_Bact PF18768.1 ETO00681.1 - 0.0095 15.5 14.1 4.6 6.9 0.0 5.3 3 2 2 5 5 5 0 Helix-turn-helix bacterial domain DUF4810 PF16068.5 ETO00681.1 - 0.012 16.1 3.3 0.85 10.2 0.1 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF4810) DUF357 PF04010.13 ETO00681.1 - 0.016 15.3 4.0 0.6 10.2 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF357) SHNi-TPR PF10516.9 ETO00681.1 - 0.016 14.6 1.0 16 5.1 0.0 4.0 4 0 0 4 4 4 0 SHNi-TPR UxuA PF03786.13 ETO00681.1 - 0.029 13.2 1.7 0.53 9.1 0.1 2.3 1 1 1 2 2 2 0 D-mannonate dehydratase (UxuA) Sel1 PF08238.12 ETO00681.1 - 0.03 15.0 13.0 12 6.7 0.3 6.0 4 3 0 4 4 4 0 Sel1 repeat ANAPC3 PF12895.7 ETO00681.1 - 0.032 14.5 7.2 0.25 11.6 0.6 3.4 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Pep3_Vps18 PF05131.14 ETO00681.1 - 0.033 14.0 1.9 3.7 7.4 0.0 3.4 2 1 1 4 4 4 0 Pep3/Vps18/deep orange family DUF3856 PF12968.7 ETO00681.1 - 0.038 14.1 1.1 7.6 6.6 0.1 2.9 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 ETO00681.1 - 0.048 13.7 16.5 1.4 9.1 0.3 4.2 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 ETO00681.1 - 0.1 12.8 0.0 6.6 7.0 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat FATC PF02260.20 ETO00681.1 - 0.18 11.6 0.9 10 6.0 0.0 3.2 4 0 0 4 4 4 0 FATC domain UPF0223 PF05256.12 ETO00681.1 - 0.19 12.1 2.9 1.6 9.1 0.3 2.5 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0223) DUF3450 PF11932.8 ETO00681.1 - 0.29 10.4 9.3 7.4 5.8 0.3 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Peripla_BP_7 PF18610.1 ETO00681.1 - 0.36 11.0 9.9 2.6 8.3 1.6 3.1 2 1 1 3 3 3 0 Periplasmic binding protein domain SPAN-X PF07458.12 ETO00681.1 - 0.4 11.2 2.6 76 3.9 0.0 3.4 3 1 1 4 4 4 0 Sperm protein associated with nucleus, mapped to X chromosome DUF1689 PF07954.11 ETO00681.1 - 0.43 11.0 2.8 30 5.0 0.3 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1689) DUF1980 PF09323.10 ETO00683.1 - 0.11 12.5 1.6 0.18 11.7 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Serinc PF03348.15 ETO00683.1 - 1.7 7.5 5.1 2.4 7.0 5.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Mak16 PF04874.14 ETO00683.1 - 3 8.5 18.5 1.4 9.5 0.9 2.3 2 0 0 2 2 2 0 Mak16 protein C-terminal region CNDH2_N PF06278.11 ETO00683.1 - 3.4 7.9 10.5 0.5 10.6 0.5 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal RNase_H2_suC PF08615.11 ETO00683.1 - 4.2 7.5 11.3 30 4.8 10.7 2.2 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) IBB PF01749.20 ETO00684.1 - 2.9e-08 34.0 1.6 9.4e-08 32.4 1.6 1.9 1 0 0 1 1 1 1 Importin beta binding domain Arm PF00514.23 ETO00684.1 - 0.041 13.9 0.4 30 4.9 0.3 3.2 2 1 0 2 2 2 0 Armadillo/beta-catenin-like repeat Paramecium_SA PF01508.16 ETO00684.1 - 0.23 11.9 7.6 0.5 10.8 7.6 1.5 1 0 0 1 1 1 0 Paramecium surface antigen domain Arm PF00514.23 ETO00685.1 - 3.2e-10 39.7 0.1 0.00099 19.1 0.0 4.3 4 0 0 4 4 4 4 Armadillo/beta-catenin-like repeat Copine PF07002.16 ETO00686.1 - 6.2e-07 29.1 0.1 1e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 Copine PPR_2 PF13041.6 ETO00687.1 - 0.00031 20.9 0.4 0.00066 19.8 0.2 1.7 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ETO00687.1 - 0.019 15.2 0.8 0.045 14.0 0.1 2.0 3 0 0 3 3 3 0 PPR repeat PPR_1 PF12854.7 ETO00687.1 - 0.099 12.4 0.1 0.2 11.4 0.1 1.6 1 0 0 1 1 1 0 PPR repeat Iwr1 PF08574.10 ETO00689.1 - 3.2 8.8 7.7 11 7.1 7.7 1.8 1 1 0 1 1 1 0 Transcription factor Iwr1 WD40 PF00400.32 ETO00692.1 - 5.7e-17 61.8 12.8 1.8e-06 28.6 0.9 4.7 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO00692.1 - 0.00018 20.3 0.1 3.7 6.1 0.0 3.0 2 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO00694.1 - 2e-57 189.8 14.7 3.1e-09 37.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00694.1 - 2.1e-21 76.0 0.5 0.0038 17.5 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO00694.1 - 1.2e-16 61.0 6.6 8.5e-05 22.0 1.8 3.9 2 2 2 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO00694.1 - 6e-10 38.6 5.0 0.0011 18.0 0.0 5.3 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO00694.1 - 1.6e-08 34.6 1.5 0.017 15.0 0.0 3.8 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO00694.1 - 1.9e-07 30.1 2.0 0.21 10.2 0.0 4.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO00694.1 - 0.0017 17.7 0.8 0.17 11.2 0.0 3.4 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO00694.1 - 0.0027 17.6 8.2 5.3 7.1 0.1 5.2 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO00694.1 - 0.021 13.6 0.0 4 6.1 0.0 3.5 2 2 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cytochrom_D1 PF02239.16 ETO00694.1 - 0.027 13.0 0.1 1.1 7.6 0.0 2.6 1 1 0 2 2 2 0 Cytochrome D1 heme domain Ricin_B_lectin PF00652.22 ETO00694.1 - 0.11 12.7 4.0 0.18 12.0 2.0 2.4 2 2 0 2 2 2 0 Ricin-type beta-trefoil lectin domain TPR_12 PF13424.6 ETO00695.1 - 1.4e-29 102.2 0.3 2.4e-10 40.5 0.0 3.1 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00695.1 - 6.4e-24 82.7 20.6 1.4e-09 37.3 1.5 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00695.1 - 1.1e-23 81.4 3.2 1.3e-08 34.3 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00695.1 - 4.7e-23 79.4 12.3 1e-07 31.5 0.4 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00695.1 - 6.5e-23 79.9 2.8 6.2e-07 29.1 0.0 4.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00695.1 - 1.5e-21 74.7 20.7 3.7e-08 32.9 2.4 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00695.1 - 9.1e-09 35.4 2.3 0.017 15.7 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO00695.1 - 2.7e-08 33.8 11.6 0.017 15.2 0.4 3.2 3 0 0 3 3 3 3 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO00695.1 - 4.8e-07 30.1 0.0 0.046 14.5 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00695.1 - 9.9e-07 29.3 0.0 0.065 13.9 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00695.1 - 7.4e-06 26.0 7.9 0.0079 16.5 0.0 4.2 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO00695.1 - 0.00023 21.1 14.3 0.03 14.3 0.9 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat SNAP PF14938.6 ETO00695.1 - 0.0055 16.2 7.0 0.023 14.2 3.5 2.4 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.9 ETO00695.1 - 0.009 15.5 0.1 16 5.0 0.0 3.2 3 0 0 3 3 3 0 SHNi-TPR DUF2225 PF09986.9 ETO00695.1 - 0.0097 15.7 5.9 0.026 14.3 2.2 2.0 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_MalT PF17874.1 ETO00695.1 - 0.011 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region Sel1 PF08238.12 ETO00695.1 - 0.012 16.3 12.9 0.87 10.4 1.8 4.8 3 3 0 3 3 3 0 Sel1 repeat Mob_Pre PF01076.19 ETO00695.1 - 0.019 14.8 2.2 0.019 14.8 2.2 1.8 2 0 0 2 2 2 0 Plasmid recombination enzyme TPR_11 PF13414.6 ETO00695.1 - 0.02 14.6 24.5 0.41 10.4 0.5 5.5 3 3 3 6 6 6 0 TPR repeat PPR PF01535.20 ETO00695.1 - 0.026 14.8 5.9 0.62 10.4 0.1 3.5 3 0 0 3 3 3 0 PPR repeat Tat PF00539.18 ETO00695.1 - 0.036 14.2 0.0 19 5.5 0.0 2.9 3 0 0 3 3 3 0 Transactivating regulatory protein (Tat) DUF5113 PF17140.4 ETO00695.1 - 0.091 12.6 16.9 0.15 11.8 0.3 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) RHD_DNA_bind PF00554.22 ETO00695.1 - 0.12 12.3 0.1 8 6.4 0.0 2.6 1 1 2 3 3 3 0 Rel homology DNA-binding domain DUF4810 PF16068.5 ETO00695.1 - 0.12 12.9 1.8 20 5.8 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4810) TPR_19 PF14559.6 ETO00695.1 - 0.13 12.8 0.7 20 5.8 0.0 2.7 2 1 0 3 3 3 0 Tetratricopeptide repeat Nsp1_C PF05064.13 ETO00695.1 - 0.25 11.2 2.4 7.9 6.3 0.1 2.8 2 1 1 3 3 3 0 Nsp1-like C-terminal region SPO22 PF08631.10 ETO00695.1 - 0.26 10.7 1.7 42 3.5 0.0 2.9 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like BAR_3 PF16746.5 ETO00695.1 - 1 9.0 3.9 17 5.1 1.5 2.7 2 1 1 3 3 3 0 BAR domain of APPL family NSF PF02071.20 ETO00695.1 - 1.2 10.1 5.7 62 5.1 0.2 3.9 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat Peptidase_C14 PF00656.22 ETO00696.1 - 6.6e-10 39.4 1.0 1e-09 38.8 1.0 1.2 1 0 0 1 1 1 1 Caspase domain Baculo_Y142 PF04913.12 ETO00697.1 - 0.036 12.8 0.1 0.041 12.6 0.1 1.0 1 0 0 1 1 1 0 Baculovirus Y142 protein WD40 PF00400.32 ETO00698.1 - 5.5e-08 33.3 0.3 4e-05 24.3 0.0 2.7 2 1 0 2 2 2 2 WD domain, G-beta repeat AAA_22 PF13401.6 ETO00699.1 - 0.0016 18.7 0.1 0.0041 17.4 0.0 1.7 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 ETO00699.1 - 0.0022 18.0 0.0 0.0043 17.0 0.0 1.5 2 0 0 2 2 1 1 NACHT domain G-alpha PF00503.20 ETO00699.1 - 0.0046 16.2 1.7 0.0054 15.9 1.1 1.3 1 1 0 1 1 1 1 G-protein alpha subunit TsaE PF02367.17 ETO00699.1 - 0.014 15.4 0.0 0.022 14.7 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 ETO00699.1 - 0.017 15.1 0.2 0.02 14.8 0.2 1.3 1 1 0 1 1 1 0 RsgA GTPase PPV_E1_C PF00519.17 ETO00699.1 - 0.021 13.6 1.5 0.59 8.9 0.0 2.1 1 1 1 2 2 2 0 Papillomavirus helicase DAP3 PF10236.9 ETO00699.1 - 0.024 13.8 0.1 0.065 12.4 0.1 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Zeta_toxin PF06414.12 ETO00699.1 - 0.026 13.8 0.0 0.047 13.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 ETO00699.1 - 0.035 14.6 4.5 0.067 13.7 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO00699.1 - 0.037 13.8 0.1 0.14 11.9 0.0 1.9 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO00699.1 - 0.044 14.2 0.9 0.092 13.1 0.0 1.9 2 1 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 ETO00699.1 - 0.048 13.4 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain EloA-BP1 PF15870.5 ETO00699.1 - 0.056 13.7 5.2 0.84 9.9 0.1 2.3 1 1 1 2 2 2 0 ElonginA binding-protein 1 VirE PF05272.11 ETO00699.1 - 0.061 13.0 0.1 0.15 11.8 0.1 1.6 1 1 1 2 2 2 0 Virulence-associated protein E Pox_A32 PF04665.12 ETO00699.1 - 0.061 12.8 0.0 0.1 12.0 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein ATP_bind_1 PF03029.17 ETO00699.1 - 0.063 13.0 1.7 2.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_30 PF13604.6 ETO00699.1 - 0.11 12.2 0.0 0.17 11.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO00699.1 - 0.12 12.5 0.2 0.43 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO00699.1 - 0.13 12.8 0.1 0.13 12.8 0.1 1.9 1 1 1 2 2 2 0 ABC transporter DUF2371 PF10177.9 ETO00699.1 - 0.13 12.4 0.4 0.26 11.4 0.3 1.5 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) AAA_16 PF13191.6 ETO00699.1 - 0.14 12.6 0.1 0.36 11.2 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain PRK PF00485.18 ETO00699.1 - 0.16 11.7 0.9 0.24 11.1 0.1 1.7 2 1 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family CPT PF07931.12 ETO00699.1 - 0.17 11.8 0.1 0.36 10.6 0.0 1.6 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein AAA_29 PF13555.6 ETO00699.1 - 0.19 11.5 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Gin PF10764.9 ETO00700.1 - 0.27 11.2 3.2 0.75 9.8 0.1 2.7 3 0 0 3 3 3 0 Inhibitor of sigma-G Gin Spore_GerAC PF05504.11 ETO00701.1 - 0.023 14.9 1.5 0.44 10.8 0.1 2.3 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal UBN_AB PF14075.6 ETO00701.1 - 0.031 14.0 0.2 0.099 12.4 0.1 1.9 1 1 1 2 2 2 0 Ubinuclein conserved middle domain OAS1_C PF10421.9 ETO00701.1 - 0.049 13.1 0.0 0.13 11.8 0.0 1.7 1 1 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus p25-alpha PF05517.12 ETO00705.1 - 0.036 14.2 4.8 1.7 8.8 0.2 2.7 2 0 0 2 2 2 0 p25-alpha Pox_D5 PF03288.16 ETO00705.1 - 1.6 9.2 6.6 6.4 7.3 1.7 2.9 2 1 0 2 2 2 0 Poxvirus D5 protein-like DUF3245 PF11595.8 ETO00706.1 - 0.0099 16.4 1.0 0.021 15.3 1.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3245) FYDLN_acid PF09538.10 ETO00706.1 - 0.013 16.1 5.0 0.013 16.1 5.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) EMP24_GP25L PF01105.24 ETO00708.1 - 2.7e-26 92.7 0.0 3e-26 92.5 0.0 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD MaoC_dehydratas PF01575.19 ETO00709.1 - 6.2e-11 41.9 0.0 1.1e-10 41.1 0.0 1.4 1 0 0 1 1 1 1 MaoC like domain Glyco_hydro_47 PF01532.20 ETO00709.1 - 0.008 15.1 0.1 0.011 14.7 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 RNase_H PF00075.24 ETO00710.1 - 5.9e-07 29.8 0.0 2.8e-06 27.6 0.0 1.8 1 1 0 1 1 1 1 RNase H Peptidase_C12 PF01088.21 ETO00711.1 - 0.0077 16.0 0.3 0.011 15.6 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 PUB PF09409.10 ETO00711.1 - 0.015 15.2 1.7 0.05 13.5 0.6 2.3 2 1 0 2 2 2 0 PUB domain Kelch_1 PF01344.25 ETO00713.1 - 8.1e-08 31.7 0.2 1.5e-07 30.8 0.2 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO00713.1 - 1.5e-05 24.9 0.0 3.1e-05 23.9 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO00713.1 - 0.00011 22.4 0.0 0.0003 21.0 0.0 1.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO00713.1 - 0.023 15.0 0.4 0.091 13.1 0.2 2.0 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO00713.1 - 0.03 14.3 0.1 0.057 13.4 0.1 1.4 1 0 0 1 1 1 0 Kelch motif ABC_tran PF00005.27 ETO00714.1 - 4.3e-19 69.4 11.1 2.9e-18 66.7 7.7 2.9 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETO00714.1 - 4.3e-05 23.2 2.4 0.00054 19.6 0.1 2.9 3 0 0 3 3 3 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO00714.1 - 0.00018 21.4 0.0 0.00039 20.4 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase SMC_N PF02463.19 ETO00714.1 - 0.0003 20.3 8.4 0.056 12.9 4.0 2.8 3 1 0 3 3 3 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO00714.1 - 0.0011 18.8 2.3 0.0011 18.8 2.3 1.8 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF87 PF01935.17 ETO00714.1 - 0.0018 18.4 0.1 0.0018 18.4 0.1 3.0 2 1 1 3 3 3 1 Helicase HerA, central domain AAA_30 PF13604.6 ETO00714.1 - 0.0034 17.1 0.0 0.0078 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ETO00714.1 - 0.0059 16.6 0.1 0.016 15.1 0.1 1.7 1 0 0 1 1 1 1 NACHT domain AAA_10 PF12846.7 ETO00714.1 - 0.0071 15.3 0.5 0.016 14.1 0.0 1.8 2 0 0 2 2 2 1 AAA-like domain MMR_HSR1 PF01926.23 ETO00714.1 - 0.0086 16.2 0.1 0.02 15.0 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ETO00714.1 - 0.017 15.4 0.2 0.1 12.9 0.1 2.2 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETO00714.1 - 0.022 14.3 0.5 0.18 11.3 0.0 2.3 2 0 0 2 2 2 0 P-loop containing dynein motor region FtsK_SpoIIIE PF01580.18 ETO00714.1 - 0.043 13.1 0.1 0.083 12.2 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_16 PF13191.6 ETO00714.1 - 0.062 13.7 0.1 0.16 12.3 0.1 1.9 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 ETO00714.1 - 0.072 13.5 3.3 2 8.8 0.0 3.2 3 0 0 3 3 3 0 RNA helicase Zeta_toxin PF06414.12 ETO00714.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 ETO00714.1 - 7.8 6.9 24.1 0.077 13.5 12.4 2.9 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO00715.1 - 2e-16 60.8 18.0 3.4e-16 60.0 11.9 3.2 2 1 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETO00715.1 - 0.00027 20.6 0.1 0.00097 18.8 0.1 2.0 1 0 0 1 1 1 1 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO00715.1 - 0.00029 20.8 0.0 0.00071 19.5 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase DUF87 PF01935.17 ETO00715.1 - 0.003 17.7 0.1 0.003 17.7 0.1 2.9 3 0 0 3 3 3 1 Helicase HerA, central domain AAA_30 PF13604.6 ETO00715.1 - 0.0066 16.2 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ETO00715.1 - 0.011 15.6 0.1 0.028 14.3 0.1 1.7 1 0 0 1 1 1 0 NACHT domain MMR_HSR1 PF01926.23 ETO00715.1 - 0.021 14.9 0.0 0.06 13.4 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ETO00715.1 - 0.038 14.3 0.5 0.18 12.1 0.1 2.4 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO00715.1 - 0.074 12.4 0.5 0.16 11.3 0.1 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family SMC_N PF02463.19 ETO00715.1 - 0.1 12.0 15.7 0.31 10.5 4.9 3.1 3 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETO00715.1 - 0.14 12.6 0.0 0.34 11.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_membrane_2 PF06472.15 ETO00716.1 - 4.1e-09 36.2 3.3 5.7e-09 35.8 3.3 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 RepA_C PF04796.12 ETO00717.1 - 2.3 8.2 5.3 6 6.9 0.2 2.2 1 1 1 2 2 2 0 Plasmid encoded RepA protein cNMP_binding PF00027.29 ETO00718.1 - 1.1e-08 35.0 0.0 1.7e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Peptidase_M57 PF12388.8 ETO00718.1 - 0.17 11.4 6.6 0.22 11.1 6.5 1.2 1 1 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Secretin_N_2 PF07655.13 ETO00718.1 - 0.37 11.4 15.3 0.59 10.7 15.3 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Nop25 PF09805.9 ETO00718.1 - 0.65 10.5 6.0 0.83 10.1 6.0 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) DUF2722 PF10846.8 ETO00718.1 - 0.88 8.4 14.0 1.1 8.2 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) NOA36 PF06524.12 ETO00718.1 - 1.4 8.1 7.9 1.7 7.9 7.9 1.1 1 0 0 1 1 1 0 NOA36 protein WD40 PF00400.32 ETO00719.1 - 3.1e-07 31.0 2.5 4.9e-06 27.2 0.1 3.1 3 1 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00719.1 - 0.042 14.2 0.0 0.076 13.3 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00719.1 - 0.07 11.8 0.0 0.07 11.8 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 DUSP PF06337.12 ETO00721.1 - 0.61 10.7 6.7 0.76 10.4 6.7 1.1 1 0 0 1 1 1 0 DUSP domain Peptidase_C14 PF00656.22 ETO00722.1 - 4.6e-10 39.9 0.3 8.1e-10 39.1 0.3 1.4 1 1 0 1 1 1 1 Caspase domain PNISR PF15996.5 ETO00723.1 - 0.0042 17.4 2.6 0.0047 17.2 2.6 1.2 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR CDC45 PF02724.14 ETO00723.1 - 0.0057 15.0 2.3 0.0055 15.1 2.3 1.2 1 0 0 1 1 1 1 CDC45-like protein Macoilin PF09726.9 ETO00723.1 - 0.0063 15.1 7.0 0.0068 15.0 7.0 1.2 1 0 0 1 1 1 1 Macoilin family TALPID3 PF15324.6 ETO00723.1 - 0.021 12.5 8.0 0.024 12.3 8.0 1.0 1 0 0 1 1 1 0 Hedgehog signalling target Zip PF02535.22 ETO00723.1 - 0.026 13.7 1.0 0.027 13.7 1.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO00723.1 - 0.064 11.6 12.4 0.076 11.4 12.4 1.1 1 0 0 1 1 1 0 Menin WDCP PF15390.6 ETO00723.1 - 0.07 11.5 4.2 0.07 11.5 4.2 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family DUF789 PF05623.12 ETO00723.1 - 0.072 12.8 6.2 0.097 12.3 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Presenilin PF01080.17 ETO00723.1 - 0.081 11.7 10.3 0.093 11.5 10.3 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 ETO00723.1 - 0.085 11.7 1.8 0.089 11.6 1.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family Tim54 PF11711.8 ETO00723.1 - 0.16 10.8 4.9 0.21 10.4 4.9 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Ndc1_Nup PF09531.10 ETO00723.1 - 0.19 10.4 5.6 0.21 10.2 5.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NPR3 PF03666.13 ETO00723.1 - 0.21 10.3 13.0 0.23 10.2 13.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NST1 PF13945.6 ETO00723.1 - 0.31 11.1 20.4 0.48 10.5 20.4 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Connexin PF00029.19 ETO00723.1 - 0.31 10.8 1.4 0.47 10.2 1.4 1.3 1 0 0 1 1 1 0 Connexin Pex14_N PF04695.13 ETO00723.1 - 0.41 11.3 9.0 0.68 10.6 9.0 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Striatin PF08232.12 ETO00723.1 - 0.68 10.5 9.2 0.94 10.1 9.2 1.3 1 0 0 1 1 1 0 Striatin family RP-C_C PF11800.8 ETO00723.1 - 0.76 9.8 4.6 1 9.4 4.6 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Sporozoite_P67 PF05642.11 ETO00723.1 - 0.91 7.5 10.2 1.1 7.3 10.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Neur_chan_memb PF02932.16 ETO00723.1 - 0.93 9.5 5.9 1.3 9.0 5.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ETO00723.1 - 0.99 8.4 11.3 1.4 7.8 11.3 1.3 1 0 0 1 1 1 0 Solute carrier family 12 CPSF100_C PF13299.6 ETO00723.1 - 1.1 9.5 6.8 1.8 8.7 6.8 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Membralin PF09746.9 ETO00723.1 - 1.6 7.7 5.8 1.7 7.6 5.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Gti1_Pac2 PF09729.9 ETO00723.1 - 3.1 7.8 15.1 0.69 10.0 12.0 1.6 2 0 0 2 2 1 0 Gti1/Pac2 family CSG2 PF16965.5 ETO00723.1 - 3.7 6.4 6.7 4.7 6.1 6.7 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4661 PF15576.6 ETO00723.1 - 3.9 7.3 5.8 5.3 6.9 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Coilin_N PF15862.5 ETO00723.1 - 5.1 6.9 13.5 8.5 6.2 13.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus Otopetrin PF03189.13 ETO00723.1 - 5.9 5.6 7.1 7.4 5.3 7.1 1.1 1 0 0 1 1 1 0 Otopetrin CCDC106 PF15794.5 ETO00723.1 - 8.9 6.0 14.9 14 5.3 14.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 CLN3 PF02487.17 ETO00723.1 - 9.2 5.2 6.3 12 4.8 6.3 1.1 1 0 0 1 1 1 0 CLN3 protein WD40 PF00400.32 ETO00724.1 - 7.6e-14 51.9 17.6 7.1e-07 29.8 1.4 4.1 3 1 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO00724.1 - 5.4e-05 22.7 0.8 0.0014 18.1 0.3 2.2 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO00724.1 - 0.00012 20.8 1.4 0.0048 15.6 0.2 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00724.1 - 0.00058 20.1 0.3 0.02 15.2 0.0 2.3 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain SGBP_B_XBD PF18329.1 ETO00725.1 - 0.021 14.8 4.1 0.026 14.5 4.1 1.2 1 0 0 1 1 1 0 Surface glycan-binding protein B xyloglucan binding domain ARGLU PF15346.6 ETO00725.1 - 0.12 12.3 19.2 0.61 10.0 7.5 2.1 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 DUF4455 PF14643.6 ETO00725.1 - 0.2 10.3 22.7 0.23 10.0 22.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) V_ATPase_I PF01496.19 ETO00725.1 - 3.8 5.3 18.9 4.1 5.2 18.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 ETO00725.1 - 4.5 6.7 16.1 6.6 6.2 16.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit tRNA-synt_1g PF09334.11 ETO00725.1 - 5.1 5.7 14.3 1.1 8.0 6.8 2.0 1 1 1 2 2 2 0 tRNA synthetases class I (M) DUF2344 PF10105.9 ETO00725.1 - 7 6.5 10.6 6.5 6.6 9.8 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) Phage_GPO PF05929.11 ETO00725.1 - 7.3 6.1 17.2 8.5 5.9 17.2 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Iron_permease PF04120.12 ETO00725.1 - 8.5 6.2 12.7 39 4.0 12.7 1.9 1 1 0 1 1 1 0 Low affinity iron permease CENP-K PF11802.8 ETO00726.1 - 0.012 15.2 5.2 0.017 14.7 5.2 1.1 1 0 0 1 1 1 0 Centromere-associated protein K Lipoprotein_7 PF01540.16 ETO00726.1 - 0.015 14.6 6.2 0.018 14.4 6.2 1.2 1 0 0 1 1 1 0 Adhesin lipoprotein Spc7 PF08317.11 ETO00726.1 - 0.038 12.9 6.1 0.045 12.6 6.1 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Pex19 PF04614.12 ETO00726.1 - 0.043 13.6 2.9 0.053 13.3 2.9 1.1 1 0 0 1 1 1 0 Pex19 protein family DUF948 PF06103.11 ETO00726.1 - 0.043 14.1 0.4 0.097 12.9 0.4 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Med21 PF11221.8 ETO00726.1 - 0.12 12.6 3.3 0.19 12.0 3.3 1.3 1 0 0 1 1 1 0 Subunit 21 of Mediator complex GBP_C PF02841.14 ETO00726.1 - 0.12 11.8 5.7 0.17 11.3 5.7 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Herpes_UL92 PF03048.14 ETO00726.1 - 0.16 11.7 2.1 0.12 12.2 1.0 1.4 2 0 0 2 2 2 0 UL92 family Seryl_tRNA_N PF02403.22 ETO00726.1 - 0.19 12.0 10.5 0.33 11.2 10.5 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Blo-t-5 PF11642.8 ETO00726.1 - 0.22 11.5 7.5 0.5 10.3 7.5 1.7 1 1 0 1 1 1 0 Mite allergen Blo t 5 WD40 PF00400.32 ETO00727.1 - 9.4e-40 133.9 30.3 8.1e-07 29.6 0.9 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00727.1 - 2.7e-12 46.8 2.2 0.056 13.7 0.0 5.5 4 2 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00727.1 - 9e-11 41.1 4.7 0.01 14.5 0.1 5.0 1 1 1 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00727.1 - 8.3e-07 28.6 6.2 0.0024 17.3 0.7 4.0 2 2 1 4 4 4 2 WD40-like domain HARP PF07443.13 ETO00727.1 - 0.015 14.9 0.4 1.9 8.2 0.0 2.9 2 0 0 2 2 2 0 HepA-related protein (HARP) NACHT PF05729.12 ETO00728.1 - 0.1 12.5 0.3 0.23 11.3 0.3 1.6 1 0 0 1 1 1 0 NACHT domain Transglut_prok PF09017.10 ETO00728.1 - 0.27 10.5 2.5 0.32 10.3 2.5 1.1 1 0 0 1 1 1 0 Microbial transglutaminase ASPRs PF17641.2 ETO00728.1 - 2.6 8.4 8.3 6 7.2 8.3 1.8 1 1 0 1 1 1 0 Ancylostoma-associated secreted protein related eIF3_N PF09440.10 ETO00730.1 - 0.059 13.8 0.1 0.1 13.0 0.1 1.4 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain zf-TRAF PF02176.18 ETO00731.1 - 0.00013 22.6 0.7 0.00013 22.6 0.7 2.6 3 1 0 3 3 3 1 TRAF-type zinc finger SPOB_ab PF14682.6 ETO00733.1 - 0.052 13.6 0.9 0.098 12.7 0.2 1.8 2 0 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal CW_binding_1 PF01473.20 ETO00733.1 - 0.97 9.9 5.4 0.81 10.1 2.2 2.6 2 0 0 2 2 2 0 Putative cell wall binding repeat MMR_HSR1 PF01926.23 ETO00734.1 - 1.2e-05 25.3 0.7 0.00016 21.8 0.2 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO00734.1 - 2.3e-05 24.4 0.3 0.00099 19.0 0.1 2.6 3 0 0 3 3 3 1 RsgA GTPase ABC_tran PF00005.27 ETO00734.1 - 0.0027 18.2 0.1 0.0027 18.2 0.1 2.3 2 1 0 2 2 2 1 ABC transporter T2SSE PF00437.20 ETO00734.1 - 0.013 14.6 0.0 0.021 13.9 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 ETO00734.1 - 0.018 14.5 0.1 0.042 13.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 ETO00734.1 - 0.022 14.5 0.1 0.054 13.2 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_28 PF13521.6 ETO00734.1 - 0.035 14.4 0.6 0.093 13.0 0.2 2.0 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETO00734.1 - 0.038 14.3 0.4 0.038 14.3 0.4 2.4 1 1 1 2 2 2 0 AAA domain Dynamin_N PF00350.23 ETO00734.1 - 0.056 13.5 5.7 1.1 9.3 0.0 3.4 2 1 1 3 3 3 0 Dynamin family MCM PF00493.23 ETO00734.1 - 0.057 12.5 0.1 0.1 11.7 0.1 1.4 1 0 0 1 1 1 0 MCM P-loop domain SRP54 PF00448.22 ETO00734.1 - 0.062 12.9 0.1 0.13 11.8 0.1 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain RNA_helicase PF00910.22 ETO00734.1 - 0.13 12.6 0.5 0.65 10.4 0.0 2.5 2 0 0 2 2 2 0 RNA helicase IstB_IS21 PF01695.17 ETO00734.1 - 0.14 11.9 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_30 PF13604.6 ETO00734.1 - 0.39 10.4 2.3 1.4 8.6 0.3 2.2 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 ETO00738.1 - 5.9e-60 197.8 23.2 1.7e-10 41.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00738.1 - 5.5e-26 90.7 1.4 0.0046 17.2 0.0 6.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO00738.1 - 2.4e-13 49.8 5.4 0.0071 15.3 0.1 6.8 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO00738.1 - 1.1e-09 38.5 0.9 0.0052 16.7 0.0 3.9 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO00738.1 - 2.5e-09 36.4 10.3 0.082 11.5 0.8 5.1 1 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO00738.1 - 3.3e-08 33.2 0.3 0.05 12.9 0.0 4.0 3 1 1 4 4 4 3 WD40-like domain PD40 PF07676.12 ETO00738.1 - 5.5e-07 29.4 3.0 1.6 8.8 0.0 6.2 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 ETO00738.1 - 3.7e-05 23.3 0.0 0.00093 18.7 0.0 2.7 1 1 3 4 4 4 1 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 ETO00738.1 - 6.2e-05 21.7 1.4 0.46 9.0 0.1 3.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO00738.1 - 0.00058 20.0 2.5 11 6.1 0.0 3.9 1 1 1 3 3 3 2 Family of unknown function (DUF5570) VID27 PF08553.10 ETO00738.1 - 0.0026 16.9 0.0 0.41 9.6 0.0 2.3 2 0 0 2 2 2 2 VID27 C-terminal WD40-like domain Proteasome_A_N PF10584.9 ETO00738.1 - 0.0056 16.3 7.6 1.8 8.4 0.1 5.0 6 0 0 6 6 6 1 Proteasome subunit A N-terminal signature DUF641 PF04859.12 ETO00740.1 - 0.027 14.8 8.5 0.13 12.6 8.2 1.8 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Spc7 PF08317.11 ETO00740.1 - 0.034 13.0 13.9 0.037 12.9 13.9 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Phage_GP20 PF06810.11 ETO00740.1 - 0.054 13.3 15.1 0.071 12.9 15.1 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF2314 PF10077.9 ETO00740.1 - 0.25 11.4 8.3 0.48 10.5 5.0 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2314) DUF3074 PF11274.8 ETO00740.1 - 0.29 11.1 2.6 0.35 10.8 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3074) MPS2 PF17060.5 ETO00740.1 - 0.56 9.4 14.2 0.19 11.0 2.2 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 UPF0242 PF06785.11 ETO00740.1 - 2.8 8.0 19.4 3.3 7.8 19.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 ETO00740.1 - 7.8 6.0 10.4 7.8 6.0 10.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Activator-TraM PF11657.8 ETO00741.1 - 0.084 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Transcriptional activator TraM Kelch_2 PF07646.15 ETO00742.1 - 0.00021 21.1 0.4 0.33 11.0 0.2 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO00742.1 - 0.0066 16.7 0.2 2.2 8.7 0.1 2.6 2 0 0 2 2 2 2 Kelch motif IL3Ra_N PF18611.1 ETO00742.1 - 0.024 14.6 0.2 0.05 13.6 0.2 1.5 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain Polbeta PF18765.1 ETO00743.1 - 0.061 13.4 0.6 0.15 12.2 0.3 1.8 1 1 1 2 2 2 0 Polymerase beta, Nucleotidyltransferase PH_12 PF16457.5 ETO00745.1 - 6.7e-11 42.9 0.8 2.4e-10 41.0 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_14 PF17787.1 ETO00745.1 - 0.00038 20.3 0.2 0.00038 20.3 0.2 2.1 2 2 1 3 3 3 1 PH domain Pox_Rif PF03340.13 ETO00745.1 - 0.00097 17.7 0.6 0.0014 17.1 0.4 1.2 1 1 0 1 1 1 1 Poxvirus rifampicin resistance protein BLYB PF05289.11 ETO00745.1 - 0.0035 17.5 0.5 0.0067 16.6 0.5 1.4 1 0 0 1 1 1 1 Borrelia hemolysin accessory protein PUB PF09409.10 ETO00746.1 - 0.021 14.8 1.3 0.071 13.1 1.3 1.9 1 1 0 1 1 1 0 PUB domain Rootletin PF15035.6 ETO00746.1 - 0.024 14.6 0.5 0.029 14.4 0.5 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4853 PF16145.5 ETO00746.1 - 0.1 12.7 0.0 0.12 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) Microtub_bd PF16796.5 ETO00748.1 - 2.1e-34 118.6 5.9 2.8e-34 118.2 5.9 1.1 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 ETO00748.1 - 4.4e-30 104.7 2.8 5.5e-30 104.4 2.8 1.1 1 0 0 1 1 1 1 Kinesin motor domain tRNA_synthFbeta PF17759.1 ETO00748.1 - 0.013 14.9 0.2 0.02 14.3 0.2 1.4 1 1 0 1 1 1 0 Phenylalanyl tRNA synthetase beta chain CLM domain NBP1 PF08537.10 ETO00748.1 - 0.015 14.7 2.7 0.021 14.3 2.7 1.2 1 0 0 1 1 1 0 Fungal Nap binding protein NBP1 ArgoMid PF16487.5 ETO00748.1 - 0.021 15.1 2.4 1 9.6 0.2 2.9 2 1 1 3 3 3 0 Mid domain of argonaute YabA PF06156.13 ETO00748.1 - 0.066 13.8 5.2 0.037 14.7 1.7 2.4 2 1 0 2 2 2 0 Initiation control protein YabA DUF5531 PF17671.1 ETO00750.1 - 0.012 15.5 3.6 0.014 15.3 3.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5531) AKNA PF12443.8 ETO00750.1 - 0.029 15.0 0.9 0.029 15.0 0.9 2.2 1 1 0 2 2 2 0 AT-hook-containing transcription factor TMF_TATA_bd PF12325.8 ETO00750.1 - 0.074 13.3 13.3 0.072 13.3 11.4 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_L PF02601.15 ETO00750.1 - 0.18 11.3 6.3 0.21 11.1 6.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit SpecificRecomb PF10136.9 ETO00750.1 - 0.23 9.7 1.9 0.25 9.6 1.9 1.0 1 0 0 1 1 1 0 Site-specific recombinase Golgin_A5 PF09787.9 ETO00750.1 - 0.29 10.6 12.1 0.42 10.0 12.1 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 UPF0449 PF15136.6 ETO00750.1 - 0.38 11.3 8.5 0.14 12.6 2.8 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 CC2-LZ PF16516.5 ETO00750.1 - 0.61 10.5 13.4 0.83 10.1 6.2 2.1 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HR1 PF02185.16 ETO00750.1 - 0.71 10.0 9.3 0.18 12.0 5.9 1.7 2 0 0 2 2 2 0 Hr1 repeat Tropomyosin_1 PF12718.7 ETO00750.1 - 0.79 9.9 16.7 2.1 8.5 16.0 2.0 1 1 0 1 1 1 0 Tropomyosin like UPF0242 PF06785.11 ETO00750.1 - 0.83 9.7 17.1 1.5 8.9 17.1 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FliD_C PF07195.12 ETO00750.1 - 0.98 8.8 9.5 0.93 8.9 2.3 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Csm1_N PF18504.1 ETO00750.1 - 1.3 9.4 17.2 1.4 9.3 2.5 3.1 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF4407 PF14362.6 ETO00750.1 - 1.5 8.1 6.2 2.1 7.6 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 ETO00750.1 - 2 6.9 8.7 2.6 6.5 8.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Swi5 PF07061.11 ETO00750.1 - 2.5 8.3 11.7 1.6 8.9 0.5 2.7 1 1 2 3 3 3 0 Swi5 ATG16 PF08614.11 ETO00750.1 - 2.5 8.3 16.6 4.5 7.4 10.2 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Ku_C PF03730.14 ETO00750.1 - 2.8 8.7 9.9 0.34 11.6 2.0 2.4 1 1 2 3 3 3 0 Ku70/Ku80 C-terminal arm Uds1 PF15456.6 ETO00750.1 - 2.8 8.1 11.4 5.5 7.2 11.2 1.8 1 1 0 1 1 1 0 Up-regulated During Septation Cluap1 PF10234.9 ETO00750.1 - 3.2 7.1 16.4 1.5 8.2 6.8 2.0 1 1 1 2 2 2 0 Clusterin-associated protein-1 SlyX PF04102.12 ETO00750.1 - 3.2 8.4 9.7 26 5.5 0.1 2.4 1 1 1 2 2 2 0 SlyX DUF745 PF05335.13 ETO00750.1 - 8 6.1 11.7 18 5.0 11.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF4652 PF15525.6 ETO00752.1 - 0.051 13.4 12.0 0.063 13.1 12.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4652) EIIBC-GUT_N PF03612.14 ETO00752.1 - 0.12 12.2 1.8 0.12 12.1 1.8 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PBP1_TM PF14812.6 ETO00752.1 - 0.13 12.6 1.2 0.15 12.4 1.2 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Orf78 PF06024.12 ETO00752.1 - 0.29 11.5 6.8 0.32 11.3 6.8 1.1 1 0 0 1 1 1 0 Orf78 (ac78) ETRAMP PF09716.10 ETO00752.1 - 2.2 8.4 8.0 2.8 8.1 8.0 1.3 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Fibrinogen_BP PF08017.11 ETO00753.1 - 0.0071 14.8 0.2 0.0083 14.6 0.2 1.1 1 0 0 1 1 1 1 Fibrinogen binding protein MREG PF15812.5 ETO00753.1 - 0.074 13.4 0.1 0.11 12.9 0.1 1.2 1 0 0 1 1 1 0 Melanoregulin EzrA PF06160.12 ETO00754.1 - 0.0039 15.4 2.1 0.0044 15.3 2.1 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA XRN_N PF03159.18 ETO00755.1 - 4.4e-12 45.9 0.1 4.4e-12 45.9 0.1 2.3 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus DAG_kinase_N PF14513.6 ETO00755.1 - 0.04 14.1 5.5 0.051 13.8 5.5 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus CobT PF06213.12 ETO00755.1 - 0.27 10.6 15.5 0.34 10.3 15.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CCDC106 PF15794.5 ETO00755.1 - 0.29 10.8 9.9 0.39 10.4 9.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 RRN3 PF05327.11 ETO00755.1 - 4.3 5.8 11.5 4.8 5.6 11.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RP-C_C PF11800.8 ETO00755.1 - 5.8 7.0 8.6 7.4 6.6 8.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region ALMT PF11744.8 ETO00755.1 - 7.8 5.2 8.4 8.8 5.0 8.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO00755.1 - 9.1 4.9 10.9 12 4.6 10.9 1.1 1 0 0 1 1 1 0 Presenilin XRN_N PF03159.18 ETO00756.1 - 5e-12 45.8 0.1 5e-12 45.8 0.1 2.5 2 1 0 2 2 1 1 XRN 5'-3' exonuclease N-terminus DAG_kinase_N PF14513.6 ETO00756.1 - 0.0074 16.5 8.5 0.0097 16.1 8.5 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus CCDC106 PF15794.5 ETO00756.1 - 0.0075 16.0 13.8 0.0099 15.6 13.8 1.2 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 106 Nop53 PF07767.11 ETO00756.1 - 0.015 14.7 17.6 0.021 14.2 17.6 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RP-C_C PF11800.8 ETO00756.1 - 0.12 12.5 10.8 0.16 12.0 10.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region EOS1 PF12326.8 ETO00756.1 - 0.14 12.1 5.3 0.19 11.6 5.3 1.3 1 0 0 1 1 1 0 N-glycosylation protein Nop14 PF04147.12 ETO00756.1 - 0.19 9.9 20.1 0.21 9.8 20.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF3827 PF12877.7 ETO00756.1 - 0.27 9.6 8.4 0.33 9.3 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CobT PF06213.12 ETO00756.1 - 0.32 10.3 18.2 0.4 10.0 18.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 ETO00756.1 - 0.54 10.1 12.8 0.67 9.7 12.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 ETO00756.1 - 1.1 8.2 15.2 1.4 7.9 15.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 ETO00756.1 - 1.8 8.6 6.9 2.2 8.3 6.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NOA36 PF06524.12 ETO00756.1 - 1.8 7.8 17.7 2.3 7.5 17.7 1.2 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO00756.1 - 2.2 7.0 14.6 2.7 6.7 14.6 1.1 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 ETO00756.1 - 2.5 5.9 9.1 3 5.6 9.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hid1 PF12722.7 ETO00756.1 - 2.8 5.9 11.1 3.3 5.7 11.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 ETO00756.1 - 2.8 7.0 9.6 3.1 6.9 9.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RRN3 PF05327.11 ETO00756.1 - 3.1 6.2 15.4 3.8 5.9 15.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 zf-TRAF PF02176.18 ETO00757.1 - 3.1e-07 31.0 4.3 9.5e-07 29.4 4.3 1.9 1 0 0 1 1 1 1 TRAF-type zinc finger DUF1644 PF07800.12 ETO00757.1 - 0.049 13.7 4.1 0.22 11.6 4.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) TPR_12 PF13424.6 ETO00759.1 - 1.8e-15 57.0 0.6 5.8e-13 48.9 0.1 2.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00759.1 - 2.5e-15 55.8 0.7 5.1e-07 29.4 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00759.1 - 6.5e-14 50.9 12.2 4.9e-07 29.5 0.4 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00759.1 - 9.7e-14 50.5 12.3 1.2e-05 24.9 0.2 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00759.1 - 1.1e-12 47.0 3.9 9.2e-07 28.5 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00759.1 - 1.1e-10 40.8 8.1 0.0038 17.2 0.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO00759.1 - 1.9e-07 30.9 4.5 0.002 18.4 0.1 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00759.1 - 0.00011 22.8 0.0 1.3 9.8 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00759.1 - 0.00061 20.3 0.1 0.47 11.2 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO00759.1 - 0.037 14.0 4.1 2.3 8.3 0.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00759.1 - 2.2 8.0 19.2 4.8 7.0 0.0 5.0 4 2 2 6 6 6 0 TPR repeat Rcd1 PF04078.13 ETO00760.1 - 0.012 14.9 0.2 0.037 13.3 0.0 1.8 2 0 0 2 2 2 0 Cell differentiation family, Rcd1-like RIBIOP_C PF04950.12 ETO00760.1 - 0.095 12.1 3.5 0.043 13.2 1.2 1.5 2 0 0 2 2 2 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Adeno_E3_CR1 PF02440.15 ETO00761.1 - 0.068 13.0 0.3 0.08 12.7 0.3 1.2 1 0 0 1 1 1 0 Adenovirus E3 region protein CR1 ResIII PF04851.15 ETO00762.1 - 0.0015 18.6 2.6 0.042 13.8 0.0 2.3 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Chitin_bind_4 PF00379.23 ETO00763.1 - 0.088 13.4 0.3 0.17 12.4 0.3 1.7 1 1 0 1 1 1 0 Insect cuticle protein zf-MIZ PF02891.20 ETO00764.1 - 0.061 13.1 0.5 0.087 12.6 0.5 1.3 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Ribonuc_red_sm PF00268.21 ETO00765.1 - 0.013 15.0 4.2 0.016 14.7 4.2 1.0 1 0 0 1 1 1 0 Ribonucleotide reductase, small chain DNA_topoisoIV PF00521.20 ETO00765.1 - 2.4 6.9 8.2 2.5 6.9 8.2 1.0 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A MSG PF02349.15 ETO00765.1 - 3.9 7.7 10.8 18 5.6 10.3 1.9 1 1 0 1 1 1 0 Major surface glycoprotein AAA_7 PF12775.7 ETO00767.1 - 0.00077 19.0 0.1 0.0038 16.8 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region DUF815 PF05673.13 ETO00767.1 - 0.0025 17.0 0.0 0.0053 15.9 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO00767.1 - 0.0053 17.3 0.1 0.0053 17.3 0.1 2.2 2 1 0 2 2 2 1 ABC transporter SurA_N_3 PF13624.6 ETO00767.1 - 0.016 15.0 0.7 0.34 10.7 0.1 2.4 2 0 0 2 2 2 0 SurA N-terminal domain PduV-EutP PF10662.9 ETO00767.1 - 0.023 14.4 0.3 0.056 13.2 0.1 1.8 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ETO00767.1 - 0.029 14.8 0.6 0.18 12.2 0.1 2.3 1 1 1 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETO00767.1 - 0.037 14.3 2.4 0.14 12.4 0.1 2.8 2 1 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ETO00767.1 - 0.052 13.5 0.2 0.052 13.5 0.2 1.9 2 1 0 2 2 2 0 RsgA GTPase TsaE PF02367.17 ETO00767.1 - 0.1 12.6 0.2 0.39 10.7 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ETO00767.1 - 2.9 8.3 5.2 0.74 10.2 0.2 2.6 3 2 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Pox_G7 PF05503.12 ETO00771.1 - 0.04 12.8 0.8 0.11 11.4 0.0 1.9 2 0 0 2 2 2 0 Poxvirus G7-like DUF2793 PF10983.8 ETO00771.1 - 0.13 12.1 0.0 0.29 11.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2793) GlcNAc PF11397.8 ETO00772.1 - 1.3e-15 57.7 0.1 2.6e-15 56.7 0.1 1.4 1 1 0 1 1 1 1 Glycosyltransferase (GlcNAc) Latrotoxin_C PF15658.6 ETO00774.1 - 0.015 15.0 0.1 0.026 14.3 0.1 1.5 1 1 0 1 1 1 0 Latrotoxin C-terminal domain DUF3671 PF12420.8 ETO00775.1 - 0.011 15.8 4.8 0.012 15.6 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function AIF_C PF14721.6 ETO00775.1 - 0.037 14.4 2.4 0.048 14.0 2.4 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Connexin PF00029.19 ETO00775.1 - 0.041 13.6 1.9 0.05 13.4 1.9 1.1 1 0 0 1 1 1 0 Connexin Comm PF15957.5 ETO00775.1 - 0.051 13.9 0.2 0.057 13.8 0.2 1.2 1 0 0 1 1 1 0 Commissureless DUF2309 PF10070.9 ETO00775.1 - 0.11 10.8 0.4 0.12 10.7 0.4 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2309) DUF3464 PF11947.8 ETO00775.1 - 0.11 12.2 4.7 0.17 11.6 4.7 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 U79_P34 PF03064.16 ETO00775.1 - 4.3 6.6 13.5 5.7 6.2 13.5 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Peptidase_S49_N PF08496.10 ETO00775.1 - 4.6 7.3 13.2 6.6 6.8 13.2 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ABC_export PF16962.5 ETO00775.1 - 6.6 5.0 6.2 6.6 5.0 6.2 1.1 1 0 0 1 1 1 0 Putative ABC exporter DUF4503 PF14951.6 ETO00776.1 - 0.0012 17.4 0.5 0.0016 17.0 0.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4503) HOOK PF05622.12 ETO00776.1 - 0.0024 16.1 16.2 0.0024 16.1 16.2 1.5 1 1 0 1 1 1 1 HOOK protein APG6_N PF17675.1 ETO00776.1 - 0.0042 17.6 25.7 0.068 13.7 6.1 2.2 2 0 0 2 2 2 2 Apg6 coiled-coil region DUF2625 PF10946.8 ETO00776.1 - 0.035 13.2 0.2 0.076 12.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF2625 DUF682 PF05081.12 ETO00776.1 - 0.05 13.3 0.3 0.084 12.6 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF682) Atg14 PF10186.9 ETO00776.1 - 0.17 10.9 21.3 0.53 9.3 7.1 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4164 PF13747.6 ETO00776.1 - 3.3 8.0 12.1 0.31 11.3 5.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) UPF0242 PF06785.11 ETO00776.1 - 6.9 6.7 23.1 1.4 9.0 7.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CENP-N PF05238.13 ETO00777.1 - 0.045 13.1 3.9 0.043 13.1 3.9 1.0 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Eapp_C PF10238.9 ETO00777.1 - 0.078 13.1 6.7 0.11 12.5 6.7 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein AAA_11 PF13086.6 ETO00777.1 - 0.2 11.4 7.0 0.23 11.2 7.0 1.1 1 0 0 1 1 1 0 AAA domain DDHD PF02862.17 ETO00777.1 - 0.3 11.2 2.2 0.37 10.9 2.2 1.2 1 0 0 1 1 1 0 DDHD domain SMN PF06003.12 ETO00777.1 - 0.34 10.1 7.4 0.49 9.6 7.4 1.3 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Astro_capsid_N PF03115.14 ETO00777.1 - 0.43 9.2 3.5 0.4 9.3 3.5 1.2 1 0 0 1 1 1 0 Astrovirus capsid protein precursor DUF4569 PF15133.6 ETO00777.1 - 0.7 9.6 5.5 0.82 9.3 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF1168 PF06658.12 ETO00777.1 - 0.71 9.7 27.8 1 9.2 27.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) AP3D1 PF06375.11 ETO00777.1 - 0.85 9.8 21.9 1.2 9.4 21.9 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF3807 PF12720.7 ETO00777.1 - 0.99 9.7 16.2 1.2 9.4 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CDC27 PF09507.10 ETO00777.1 - 1.8 7.9 21.5 2 7.7 21.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SOBP PF15279.6 ETO00777.1 - 2.1 8.9 6.4 2.4 8.7 6.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 ETO00777.1 - 2.1 7.0 5.3 2.9 6.5 5.3 1.3 1 0 0 1 1 1 0 Presenilin CAS_C PF12026.8 ETO00777.1 - 2.9 7.9 10.2 3.7 7.6 10.2 1.1 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Vfa1 PF08432.10 ETO00777.1 - 3.2 8.0 19.9 4.1 7.7 19.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SR-25 PF10500.9 ETO00777.1 - 3.7 7.1 30.4 5.2 6.6 30.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1764 PF08576.10 ETO00777.1 - 4.3 8.3 17.3 6.2 7.8 17.3 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) MAS20 PF02064.15 ETO00777.1 - 4.4 7.4 14.0 6.3 6.9 14.0 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor ORC_WH_C PF18137.1 ETO00777.1 - 5.2 7.1 11.0 7 6.7 11.0 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal ORC5_C PF14630.6 ETO00777.1 - 8.6 5.8 7.9 11 5.5 7.9 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus RT_RNaseH_2 PF17919.1 ETO00778.1 - 3e-33 113.8 0.1 4.8e-33 113.2 0.1 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETO00778.1 - 7.6e-29 100.1 0.2 1.5e-28 99.2 0.2 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ETO00778.1 - 2.3e-17 63.2 1.7 3.3e-17 62.8 0.1 1.9 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF498 PF04430.14 ETO00778.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) DUF3769 PF12600.8 ETO00782.1 - 0.092 11.6 0.1 0.1 11.5 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3769) Stn1 PF10451.9 ETO00783.1 - 0.011 14.7 0.2 0.014 14.4 0.2 1.2 1 0 0 1 1 1 0 Telomere regulation protein Stn1 Cys_knot PF00007.22 ETO00783.1 - 0.055 13.8 5.9 0.069 13.5 5.9 1.2 1 0 0 1 1 1 0 Cystine-knot domain DUF1644 PF07800.12 ETO00783.1 - 0.35 10.9 8.7 0.07 13.2 5.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Amino_oxidase PF01593.24 ETO00784.1 - 2.4e-18 66.7 0.0 2.2e-14 53.6 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DDHD PF02862.17 ETO00784.1 - 0.0078 16.4 1.2 0.0083 16.3 1.2 1.1 1 0 0 1 1 1 1 DDHD domain FSA_C PF10479.9 ETO00784.1 - 0.019 13.1 15.7 0.026 12.7 15.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Med13_C PF06333.12 ETO00784.1 - 0.02 14.2 7.7 0.023 13.9 7.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain DUF3391 PF11871.8 ETO00784.1 - 0.028 14.9 0.0 0.088 13.3 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Presenilin PF01080.17 ETO00784.1 - 0.038 12.7 6.0 0.046 12.5 6.0 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO00784.1 - 0.12 11.0 5.4 0.13 10.8 5.4 1.0 1 0 0 1 1 1 0 Macoilin family PAP1 PF08601.10 ETO00784.1 - 0.26 11.0 10.9 0.34 10.6 10.9 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 CCDC71L PF15374.6 ETO00784.1 - 0.27 10.5 8.3 0.34 10.1 8.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SAPS PF04499.15 ETO00784.1 - 0.29 9.9 6.5 0.35 9.6 6.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 ETO00784.1 - 2 8.2 10.2 2.8 7.7 10.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AJAP1_PANP_C PF15298.6 ETO00784.1 - 2.5 8.3 18.7 3.8 7.7 18.7 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Hid1 PF12722.7 ETO00784.1 - 3.3 5.7 9.6 4.3 5.3 9.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Zip PF02535.22 ETO00784.1 - 3.8 6.6 5.2 4.9 6.3 5.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 ETO00784.1 - 4.3 6.1 8.3 5.9 5.7 8.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 ETO00784.1 - 4.8 6.1 11.5 6.4 5.7 11.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 HU-CCDC81_bac_2 PF18175.1 ETO00785.1 - 0.0078 16.1 0.1 0.033 14.1 0.0 2.1 2 0 0 2 2 2 1 CCDC81-like prokaryotic HU domain 2 ATP12 PF07542.11 ETO00785.1 - 0.16 12.1 1.4 3.9 7.6 0.2 3.1 3 0 0 3 3 3 0 ATP12 chaperone protein ssDNA_DBD PF18333.1 ETO00785.1 - 0.27 11.3 0.1 0.27 11.3 0.1 2.1 2 1 0 2 2 2 0 Non-canonical single-stranded DNA-binding domain FKBP_C PF00254.28 ETO00787.1 - 3e-09 37.1 0.2 3.7e-09 36.8 0.2 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TB PF00683.17 ETO00787.1 - 0.016 14.9 0.5 0.032 14.0 0.1 1.7 2 0 0 2 2 2 0 TB domain FYDLN_acid PF09538.10 ETO00787.1 - 0.017 15.8 9.7 0.017 15.8 9.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Zip PF02535.22 ETO00787.1 - 0.049 12.9 0.3 0.068 12.4 0.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BUD22 PF09073.10 ETO00787.1 - 0.059 12.7 10.6 0.091 12.1 10.6 1.2 1 0 0 1 1 1 0 BUD22 Peptidase_A4 PF01828.17 ETO00787.1 - 0.086 12.3 0.1 0.13 11.7 0.1 1.2 1 0 0 1 1 1 0 Peptidase A4 family V_ATPase_I PF01496.19 ETO00787.1 - 0.1 10.5 0.7 0.14 10.1 0.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 ETO00787.1 - 0.3 9.8 4.2 0.23 10.2 3.0 1.4 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Cwf_Cwc_15 PF04889.12 ETO00787.1 - 1.6 8.4 18.1 2.7 7.6 18.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETO00787.1 - 2.7 7.2 12.6 4.9 6.4 12.6 1.4 1 0 0 1 1 1 0 NOA36 protein EF-hand_7 PF13499.6 ETO00788.1 - 0.0017 18.8 0.0 0.0054 17.2 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair DUF3915 PF13054.6 ETO00788.1 - 0.0061 16.5 1.3 0.013 15.5 1.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3915) EF-hand_1 PF00036.32 ETO00788.1 - 0.015 14.8 0.1 0.12 12.0 0.0 2.4 2 1 1 3 3 3 0 EF hand EF-hand_6 PF13405.6 ETO00788.1 - 0.053 13.5 0.1 0.23 11.5 0.1 2.1 1 1 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 ETO00788.1 - 0.49 10.0 3.4 2.9 7.5 0.0 3.0 3 0 0 3 3 3 0 EF hand Presenilin PF01080.17 ETO00788.1 - 0.89 8.3 6.6 1.4 7.6 6.6 1.4 1 0 0 1 1 1 0 Presenilin Arabino_trans_C PF14896.6 ETO00788.1 - 3 6.8 11.5 0.39 9.7 3.2 2.2 1 1 1 2 2 2 0 EmbC C-terminal domain Connexin PF00029.19 ETO00788.1 - 6.7 6.4 6.2 1.1 8.9 2.2 1.7 2 0 0 2 2 2 0 Connexin CENP-B_dimeris PF09026.10 ETO00789.1 - 0.027 14.9 1.2 0.055 13.9 1.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF364 PF04016.12 ETO00790.1 - 0.17 11.5 0.0 0.27 10.8 0.0 1.3 1 0 0 1 1 1 0 Putative heavy-metal chelation DEP PF00610.21 ETO00791.1 - 4.1e-08 33.2 2.3 1.4e-07 31.5 0.0 2.6 2 1 1 3 3 3 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PH PF00169.29 ETO00792.1 - 0.0078 16.7 0.4 0.027 15.0 0.4 2.0 1 0 0 1 1 1 1 PH domain DUF3439 PF11921.8 ETO00793.1 - 0.011 15.7 2.5 0.024 14.6 2.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO00793.1 - 0.017 13.2 1.8 0.026 12.6 1.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Inp1 PF12634.7 ETO00793.1 - 0.022 14.8 1.3 0.072 13.1 0.2 2.1 2 0 0 2 2 2 0 Inheritance of peroxisomes protein 1 FUN14 PF04930.15 ETO00793.1 - 0.12 12.8 0.2 21 5.6 0.0 2.3 2 0 0 2 2 2 0 FUN14 family SSP160 PF06933.11 ETO00793.1 - 1.5 6.9 9.3 2.5 6.2 9.3 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Menin PF05053.13 ETO00794.1 - 0.027 12.9 5.6 0.023 13.1 5.6 1.1 1 0 0 1 1 1 0 Menin FSA_C PF10479.9 ETO00794.1 - 0.1 10.7 13.8 0.12 10.5 13.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus EST1_DNA_bind PF10373.9 ETO00794.1 - 0.16 11.4 7.8 0.17 11.3 7.8 1.0 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain Dicty_REP PF05086.12 ETO00794.1 - 0.38 8.7 14.1 0.4 8.6 14.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NST1 PF13945.6 ETO00794.1 - 0.49 10.5 8.6 0.8 9.8 8.6 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Mucin PF01456.17 ETO00794.1 - 0.68 9.9 22.7 1.2 9.2 22.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein CUE PF02845.16 ETO00795.1 - 0.0002 21.0 0.3 0.084 12.6 0.1 2.7 2 1 0 2 2 2 2 CUE domain DUF3654 PF12376.8 ETO00795.1 - 0.046 13.9 1.1 0.11 12.7 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3654) DUF2140 PF09911.9 ETO00795.1 - 0.05 13.2 2.0 0.18 11.4 2.0 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) PfUIS3 PF11567.8 ETO00795.1 - 0.2 12.0 3.8 0.12 12.7 0.9 2.0 2 0 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein DUF1746 PF08508.10 ETO00796.1 - 0.062 13.6 0.1 0.066 13.5 0.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) Cys_rich_VLP PF14194.6 ETO00799.1 - 0.0087 16.2 0.1 0.016 15.3 0.1 1.4 1 0 0 1 1 1 1 Cysteine-rich VLP Kelch_1 PF01344.25 ETO00803.1 - 6.6e-08 32.0 0.1 1.3e-06 27.9 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO00803.1 - 6.4e-07 29.4 0.8 8.1e-05 22.8 0.2 2.2 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO00803.1 - 9.7e-07 28.7 0.1 6.3e-06 26.1 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO00803.1 - 2.2e-05 24.6 0.0 0.00025 21.2 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00803.1 - 6.5e-05 22.8 1.7 0.0065 16.4 0.8 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO00803.1 - 6.6e-05 22.7 0.2 0.00074 19.4 0.2 2.1 2 0 0 2 2 2 1 Kelch motif ART PF01129.18 ETO00805.1 - 0.0054 16.0 0.0 0.0077 15.5 0.0 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase HSCB_C PF07743.13 ETO00806.1 - 0.028 14.9 0.2 0.057 13.9 0.2 1.5 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain Ank_3 PF13606.6 ETO00807.1 - 8.7e-07 28.8 0.4 0.17 12.5 0.0 3.7 3 1 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ETO00807.1 - 2.6e-05 24.7 1.2 8.2e-05 23.1 0.4 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO00807.1 - 0.00014 22.1 0.4 0.00065 19.9 0.2 2.2 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO00807.1 - 0.00039 20.9 0.4 0.0024 18.4 0.2 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DNA_pol_E_B PF04042.16 ETO00807.1 - 0.0075 15.6 0.1 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Ank PF00023.30 ETO00807.1 - 0.018 15.5 0.1 0.28 11.7 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat NACHT PF05729.12 ETO00808.1 - 2.9e-06 27.3 0.1 8.6e-06 25.8 0.1 1.7 1 1 0 1 1 1 1 NACHT domain DUF1863 PF08937.11 ETO00808.1 - 0.075 13.3 1.7 0.095 13.0 0.6 1.6 1 1 1 2 2 2 0 MTH538 TIR-like domain (DUF1863) PPR_2 PF13041.6 ETO00809.1 - 6.4e-08 32.7 1.7 0.0004 20.5 0.2 3.2 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETO00809.1 - 5.1e-07 29.5 1.0 0.014 15.6 0.1 3.0 2 0 0 2 2 2 2 PPR repeat PPR_1 PF12854.7 ETO00809.1 - 0.00083 19.0 1.2 0.018 14.7 0.0 2.5 2 0 0 2 2 2 1 PPR repeat PPR_3 PF13812.6 ETO00809.1 - 0.09 12.9 2.8 0.72 10.0 0.8 3.2 3 1 1 4 4 4 0 Pentatricopeptide repeat domain WD40 PF00400.32 ETO00811.1 - 2.3e-05 25.1 1.3 0.0019 19.0 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO00811.1 - 0.00027 19.7 0.0 0.00035 19.3 0.0 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Kelch_4 PF13418.6 ETO00812.1 - 2.5e-07 30.6 0.1 0.85 9.7 0.0 4.1 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO00812.1 - 1.2e-06 28.0 0.9 0.00095 18.7 0.0 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO00812.1 - 0.00017 21.5 1.1 0.69 10.0 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO00812.1 - 0.00044 20.2 0.8 13 5.9 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Nuf2 PF03800.14 ETO00813.1 - 0.021 14.9 0.1 0.025 14.7 0.1 1.1 1 0 0 1 1 1 0 Nuf2 family WD40 PF00400.32 ETO00814.1 - 3.5e-08 34.0 2.9 8.5e-08 32.8 1.1 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO00814.1 - 0.0014 17.4 0.2 0.0017 17.1 0.2 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 IL11 PF07400.11 ETO00814.1 - 0.0078 15.9 0.1 0.011 15.4 0.1 1.1 1 0 0 1 1 1 1 Interleukin 11 Csm1_N PF18504.1 ETO00814.1 - 0.03 14.7 8.5 0.046 14.1 8.5 1.3 1 0 0 1 1 1 0 Csm1 N-terminal domain TssO PF17561.2 ETO00814.1 - 0.044 13.9 6.0 0.065 13.3 6.0 1.4 1 0 0 1 1 1 0 Type VI secretion system, TssO PIEZO PF15917.5 ETO00814.1 - 0.05 13.1 2.4 0.055 12.9 2.4 1.1 1 0 0 1 1 1 0 Piezo ANAPC4_WD40 PF12894.7 ETO00814.1 - 0.068 13.5 0.0 0.16 12.3 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3573 PF12097.8 ETO00814.1 - 0.07 12.0 3.9 0.079 11.8 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DivIC PF04977.15 ETO00814.1 - 1.6 8.6 6.4 2.3 8.0 6.4 1.4 1 0 0 1 1 1 0 Septum formation initiator UPF0242 PF06785.11 ETO00814.1 - 2.4 8.2 8.4 3.5 7.7 8.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Enterotoxin_b PF01376.18 ETO00815.1 - 0.0044 17.2 0.8 0.011 15.9 0.8 1.7 1 0 0 1 1 1 1 Heat-labile enterotoxin beta chain CC2-LZ PF16516.5 ETO00815.1 - 0.032 14.6 11.1 0.032 14.6 11.1 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator zf-RING_2 PF13639.6 ETO00815.1 - 0.05 13.9 1.1 0.05 13.9 1.1 3.0 2 1 1 3 3 3 0 Ring finger domain YjcZ PF13990.6 ETO00815.1 - 0.1 12.0 4.0 0.14 11.5 4.0 1.2 1 0 0 1 1 1 0 YjcZ-like protein HalX PF08663.10 ETO00815.1 - 0.21 11.9 1.2 1.8 9.0 0.8 2.3 2 0 0 2 2 2 0 HalX domain Phasin PF05597.11 ETO00815.1 - 0.35 10.9 11.0 0.27 11.3 5.5 2.3 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) FAM76 PF16046.5 ETO00815.1 - 0.5 9.7 31.0 1 8.6 31.0 1.5 1 1 0 1 1 1 0 FAM76 protein TMF_TATA_bd PF12325.8 ETO00815.1 - 0.71 10.1 18.9 1.5 9.1 7.2 2.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF603 PF04645.12 ETO00815.1 - 0.85 9.3 8.7 0.26 11.0 3.9 2.0 1 1 1 2 2 2 0 Protein of unknown function, DUF603 LPP PF04728.13 ETO00815.1 - 2.2 8.7 11.8 7.9e+02 0.6 11.8 3.5 1 1 0 1 1 1 0 Lipoprotein leucine-zipper CENP-H PF05837.12 ETO00815.1 - 2.3 8.7 16.7 1.1 9.6 11.0 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Bap31_Bap29_C PF18035.1 ETO00815.1 - 3.3 7.8 16.3 1.1 9.4 1.4 3.1 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain HR1 PF02185.16 ETO00815.1 - 5.6 7.1 21.3 0.99 9.6 2.0 4.0 2 1 2 4 4 4 0 Hr1 repeat Mt_ATP-synt_D PF05873.12 ETO00815.1 - 7.5 6.4 13.6 0.66 9.8 2.4 3.0 2 1 1 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) Ras PF00071.22 ETO00818.1 - 1.1e-17 64.1 2.4 7.6e-17 61.4 2.4 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO00818.1 - 1e-16 61.2 1.4 4.8e-15 55.8 1.4 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO00818.1 - 8.8e-07 28.5 0.2 0.00015 21.3 0.2 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO00818.1 - 1.5e-06 28.3 0.0 1.9e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase TniB PF05621.11 ETO00818.1 - 0.0006 19.3 0.0 0.00082 18.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein SRPRB PF09439.10 ETO00818.1 - 0.0018 17.7 0.3 0.027 13.9 0.3 2.0 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Gtr1_RagA PF04670.12 ETO00818.1 - 0.017 14.5 0.1 0.026 13.9 0.1 1.3 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region MCM PF00493.23 ETO00818.1 - 0.067 12.3 0.0 0.12 11.4 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain Dynamin_N PF00350.23 ETO00818.1 - 0.13 12.3 1.3 0.26 11.3 1.3 1.6 1 1 0 1 1 1 0 Dynamin family AAA_22 PF13401.6 ETO00818.1 - 0.15 12.3 0.0 0.2 11.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ETO00818.1 - 0.17 11.6 5.4 0.63 9.7 5.4 1.7 1 1 0 1 1 1 0 AAA ATPase domain NPCC PF08058.11 ETO00819.1 - 0.11 12.5 0.2 0.11 12.5 0.2 1.9 1 1 1 2 2 2 0 Nuclear pore complex component Kelch_5 PF13854.6 ETO00826.1 - 1.8e-06 27.8 2.9 0.0049 16.8 0.9 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO00826.1 - 1.9e-06 27.3 1.1 0.00029 20.3 0.4 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO00826.1 - 4.3e-06 26.8 1.4 0.58 10.5 0.7 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO00826.1 - 0.00037 20.4 0.2 0.13 12.3 0.2 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO00826.1 - 0.0025 17.7 8.8 0.035 14.1 0.2 4.9 5 1 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO00826.1 - 0.016 15.5 0.6 0.14 12.5 0.3 2.8 4 0 0 4 4 4 0 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO00826.1 - 0.026 13.7 0.1 0.77 8.9 0.1 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase U-box PF04564.15 ETO00827.1 - 2e-11 43.9 1.5 8.4e-11 41.9 0.1 2.6 2 0 0 2 2 2 1 U-box domain TraN PF06986.11 ETO00827.1 - 0.0027 17.4 2.9 0.0038 17.0 2.9 1.4 1 0 0 1 1 1 1 Type-1V conjugative transfer system mating pair stabilisation SAM_1 PF00536.30 ETO00827.1 - 0.02 15.3 0.9 0.052 14.0 0.0 2.1 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) LOH1CR12 PF10158.9 ETO00827.1 - 0.2 11.7 10.5 0.78 9.8 6.0 2.5 1 1 1 2 2 2 0 Tumour suppressor protein KapB PF08810.10 ETO00827.1 - 2.3 8.4 7.3 5.2 7.3 0.6 2.9 1 1 0 2 2 2 0 Kinase associated protein B G-gamma PF00631.22 ETO00827.1 - 2.5 8.2 5.6 2.2 8.4 0.4 2.9 2 1 0 2 2 2 0 GGL domain Lipoprotein_2 PF00921.17 ETO00827.1 - 3.4 7.1 11.3 2.8 7.4 1.4 2.1 2 0 0 2 2 2 0 Borrelia lipoprotein Ran_BP1 PF00638.18 ETO00831.1 - 7.1e-06 26.3 0.6 1e-05 25.8 0.1 1.5 2 0 0 2 2 2 1 RanBP1 domain PcrB PF01884.17 ETO00832.1 - 0.028 13.9 0.0 0.05 13.1 0.0 1.3 1 0 0 1 1 1 0 PcrB family DUF4834 PF16118.5 ETO00832.1 - 0.1 13.6 0.1 0.1 13.6 0.1 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) ECSCR PF15820.5 ETO00832.1 - 5.5 6.9 0.0 5.5 6.9 0.0 3.3 3 1 1 4 4 4 0 Endothelial cell-specific chemotaxis regulator DUF2663 PF10864.8 ETO00832.1 - 5.6 7.4 6.5 4.5 7.7 2.1 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2663) NOA36 PF06524.12 ETO00834.1 - 0.00012 21.6 0.4 0.00016 21.1 0.4 1.1 1 0 0 1 1 1 1 NOA36 protein FIIND PF13553.6 ETO00835.1 - 0.009 15.4 0.3 0.01 15.3 0.3 1.3 1 1 0 1 1 1 1 Function to find zf-C3HC4_2 PF13923.6 ETO00836.1 - 0.76 9.7 8.2 2.9 7.8 4.9 3.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Sua5_yciO_yrdC PF01300.18 ETO00837.1 - 0.068 12.7 0.4 0.093 12.2 0.4 1.2 1 0 0 1 1 1 0 Telomere recombination PBP_dimer PF03717.15 ETO00837.1 - 0.65 10.3 4.9 0.95 9.8 4.9 1.2 1 0 0 1 1 1 0 Penicillin-binding Protein dimerisation domain G-alpha PF00503.20 ETO00838.1 - 1.5e-62 211.8 2.2 1.8e-50 172.1 0.3 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO00838.1 - 1.5e-12 47.3 0.0 2.6e-09 36.8 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO00838.1 - 0.00016 21.9 0.0 0.14 12.3 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO00838.1 - 0.00037 20.6 0.0 0.16 12.0 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase Rad17 PF03215.15 ETO00838.1 - 0.033 14.1 0.1 0.15 11.9 0.0 1.9 1 1 1 2 2 2 0 Rad17 P-loop domain Gtr1_RagA PF04670.12 ETO00838.1 - 0.27 10.6 2.2 0.61 9.4 0.0 2.4 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ETO00839.1 - 1.4e-48 165.9 0.7 1.5e-47 162.5 0.7 1.9 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO00839.1 - 8.2e-07 28.6 0.0 1.2e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family KinB_sensor PF16767.5 ETO00840.1 - 0.043 14.3 2.7 0.16 12.4 0.6 2.7 1 1 1 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB ERCC4 PF02732.15 ETO00840.1 - 1.2 9.4 9.3 4.8 7.4 1.1 2.8 2 1 1 3 3 3 0 ERCC4 domain AAA PF00004.29 ETO00841.1 - 0.0011 19.4 0.0 0.0043 17.5 0.0 2.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF815 PF05673.13 ETO00841.1 - 0.0011 18.2 0.0 0.003 16.8 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 ETO00841.1 - 0.0017 18.3 0.0 0.01 15.8 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_5 PF07728.14 ETO00841.1 - 0.0022 18.0 0.0 0.0094 16.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO00841.1 - 0.0037 17.8 4.0 0.01 16.4 0.1 3.4 3 1 0 3 3 2 1 ABC transporter AAA_7 PF12775.7 ETO00841.1 - 0.0039 16.7 0.0 0.012 15.1 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 ETO00841.1 - 0.006 16.9 0.5 0.06 13.6 0.0 3.0 4 0 0 4 4 3 1 AAA domain AAA_19 PF13245.6 ETO00841.1 - 0.035 14.4 0.3 21 5.4 0.1 3.1 3 0 0 3 3 3 0 AAA domain PduV-EutP PF10662.9 ETO00841.1 - 0.042 13.6 0.4 0.22 11.3 0.1 2.4 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation TsaE PF02367.17 ETO00841.1 - 0.045 13.7 0.2 0.35 10.9 0.1 2.6 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETO00841.1 - 0.08 13.3 0.1 0.51 10.7 0.0 2.4 3 0 0 3 3 3 0 AAA ATPase domain Roc PF08477.13 ETO00841.1 - 0.19 11.9 2.1 7 6.9 0.0 4.1 4 1 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase ubiquitin PF00240.23 ETO00842.1 - 7.9e-11 41.6 0.0 1.6e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family VWA_2 PF13519.6 ETO00842.1 - 0.0036 17.9 0.1 0.015 15.9 0.0 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain MG4 PF17789.1 ETO00842.1 - 0.014 15.5 0.0 0.03 14.5 0.0 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG4 Rad60-SLD PF11976.8 ETO00842.1 - 0.072 12.9 0.1 0.39 10.6 0.0 2.3 3 0 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like WD40 PF00400.32 ETO00844.1 - 2.3e-09 37.7 2.0 5.6e-09 36.5 2.0 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat DUF4570 PF15134.6 ETO00844.1 - 0.00018 21.5 3.0 0.00024 21.1 3.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4570) Nup160 PF11715.8 ETO00844.1 - 0.00091 18.0 0.4 0.0011 17.7 0.2 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Clusterin PF01093.17 ETO00844.1 - 0.00092 18.4 3.9 0.00096 18.3 3.9 1.1 1 0 0 1 1 1 1 Clusterin ATP11 PF06644.11 ETO00844.1 - 0.0022 17.8 1.8 0.0029 17.4 1.8 1.1 1 0 0 1 1 1 1 ATP11 protein APG17 PF04108.12 ETO00844.1 - 0.0062 15.7 4.1 0.0066 15.6 4.1 1.1 1 0 0 1 1 1 1 Autophagy protein Apg17 Nmad5 PF18757.1 ETO00844.1 - 0.009 16.2 0.3 0.01 16.1 0.3 1.1 1 0 0 1 1 1 1 Nucleotide modification associated domain 5 ANAPC4_WD40 PF12894.7 ETO00844.1 - 0.031 14.6 0.1 0.083 13.2 0.0 1.9 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4407 PF14362.6 ETO00844.1 - 0.08 12.3 2.2 0.11 11.9 2.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 ETO00844.1 - 0.098 13.3 2.7 0.18 12.5 2.7 1.5 1 0 0 1 1 1 0 Initiation control protein YabA FAM76 PF16046.5 ETO00844.1 - 0.29 10.4 14.8 0.048 13.0 10.7 1.7 1 1 1 2 2 2 0 FAM76 protein GlcNAc-1_reg PF18440.1 ETO00844.1 - 0.39 11.0 3.1 0.62 10.3 1.8 2.0 2 0 0 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain Ax_dynein_light PF10211.9 ETO00844.1 - 7.2 6.5 14.5 0.26 11.2 7.3 1.9 1 1 1 2 2 2 0 Axonemal dynein light chain zf-RING_4 PF14570.6 ETO00846.1 - 3.3e-07 30.0 8.1 3.3e-07 30.0 8.1 2.1 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 ETO00846.1 - 8.7e-05 22.4 11.3 8.7e-05 22.4 11.3 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETO00846.1 - 0.00011 22.5 13.4 0.00011 22.5 13.4 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ETO00846.1 - 0.0013 18.6 12.0 0.0029 17.5 12.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO00846.1 - 0.0077 16.2 6.7 0.016 15.2 6.7 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO00846.1 - 0.0078 16.0 10.6 0.017 15.0 10.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO00846.1 - 0.037 13.9 15.7 0.028 14.3 13.5 2.0 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Rpp20 PF12328.8 ETO00846.1 - 0.13 12.2 0.0 11 6.0 0.0 2.8 2 1 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P WD40 PF00400.32 ETO00848.1 - 5.3e-108 349.9 49.4 1.7e-12 47.6 0.1 11.4 12 0 0 12 12 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00848.1 - 1.5e-41 140.6 7.2 0.00019 21.6 0.0 9.8 1 1 9 10 10 10 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO00848.1 - 1.2e-21 77.0 5.4 0.11 11.4 0.0 9.4 1 1 9 10 10 10 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO00848.1 - 3.8e-20 72.4 8.7 9.3e-05 21.9 0.1 6.4 3 2 3 6 6 6 5 WD40-like domain Nup160 PF11715.8 ETO00848.1 - 3.7e-12 45.7 15.0 0.0069 15.1 0.1 8.0 1 1 5 8 8 8 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO00848.1 - 3.9e-11 42.6 12.4 1 9.4 0.0 9.4 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO00848.1 - 1.2e-10 41.4 4.7 2.3 8.3 0.1 8.2 2 2 6 8 8 8 2 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 ETO00848.1 - 4e-10 38.8 2.2 0.084 11.4 0.0 5.2 1 1 5 6 6 6 4 Cytochrome D1 heme domain DUF727 PF05303.12 ETO00848.1 - 9.3e-08 32.1 2.9 0.71 10.0 0.0 7.1 2 2 7 9 9 9 1 Protein of unknown function (DUF727) Frtz PF11768.8 ETO00848.1 - 1.2e-07 30.5 0.8 0.35 9.1 0.0 5.0 3 3 1 5 5 5 2 WD repeat-containing and planar cell polarity effector protein Fritz HARP PF07443.13 ETO00848.1 - 6e-07 29.0 0.0 6.5 6.5 0.0 6.2 7 0 0 7 7 7 2 HepA-related protein (HARP) DPPIV_N PF00930.21 ETO00848.1 - 2.8e-06 26.4 2.2 0.055 12.2 0.0 5.6 2 2 4 7 7 7 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Reg_prop PF07494.11 ETO00848.1 - 1.6e-05 24.6 1.6 3.4 8.2 0.0 6.8 7 0 0 7 7 6 1 Two component regulator propeller Str_synth PF03088.16 ETO00848.1 - 0.0001 22.3 0.5 3.7 7.7 0.0 5.3 3 3 2 5 5 5 1 Strictosidine synthase Proteasome_A_N PF10584.9 ETO00848.1 - 0.00049 19.7 17.9 12 5.7 0.0 9.4 10 0 0 10 10 10 0 Proteasome subunit A N-terminal signature SGL PF08450.12 ETO00848.1 - 0.00053 19.7 1.0 5.9 6.4 0.0 3.8 1 1 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Peptidase_S29 PF02907.15 ETO00848.1 - 0.0058 16.4 1.7 0.81 9.4 0.2 3.2 2 1 1 3 3 3 1 Hepatitis C virus NS3 protease DUF4221 PF13970.6 ETO00848.1 - 0.0074 15.9 5.5 2.3 7.7 0.1 4.4 2 2 3 5 5 5 1 Domain of unknown function (DUF4221) DUF4123 PF13503.6 ETO00848.1 - 0.071 13.5 0.0 19 5.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4123) ArlS_N PF18719.1 ETO00848.1 - 0.14 12.4 0.7 4 7.6 0.0 3.4 4 1 0 5 5 4 0 ArlS sensor domain B_lectin PF01453.24 ETO00848.1 - 0.16 12.5 7.7 39 4.9 0.0 4.7 2 2 3 6 6 6 0 D-mannose binding lectin PH_TFIIH PF08567.11 ETO00848.1 - 0.47 10.8 4.7 45 4.5 0.0 4.7 4 1 2 6 6 5 0 TFIIH p62 subunit, N-terminal domain Dynamitin PF04912.14 ETO00849.1 - 0.015 14.7 0.6 0.016 14.6 0.6 1.2 1 0 0 1 1 1 0 Dynamitin NPA PF16469.5 ETO00849.1 - 0.1 13.2 0.3 0.1 13.2 0.3 1.9 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 FlxA PF14282.6 ETO00849.1 - 0.35 10.9 4.2 0.89 9.6 1.4 2.6 2 1 1 3 3 3 0 FlxA-like protein LPP PF04728.13 ETO00849.1 - 0.65 10.4 4.6 3.5 8.1 0.5 2.7 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Peptidase_C14 PF00656.22 ETO00851.1 - 1.5e-09 38.2 1.8 2.3e-09 37.6 1.8 1.3 1 1 0 1 1 1 1 Caspase domain KIP1 PF07765.12 ETO00851.1 - 0.027 14.6 0.2 2.9 8.1 0.1 2.2 2 0 0 2 2 2 0 KIP1-like protein MitMem_reg PF13012.6 ETO00851.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.4 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function TaqI_C PF12950.7 ETO00852.1 - 0.032 14.3 0.7 0.05 13.7 0.6 1.5 1 1 0 1 1 1 0 TaqI-like C-terminal specificity domain DHC_N1 PF08385.12 ETO00854.1 - 0.00018 20.3 3.1 0.0002 20.2 3.1 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 tRNA-synt_1g PF09334.11 ETO00855.1 - 0.069 11.9 0.3 0.087 11.6 0.3 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (M) 4PPT_N PF17837.1 ETO00857.1 - 0.18 12.0 0.0 0.26 11.5 0.0 1.3 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain NESP55 PF06390.12 ETO00859.1 - 0.51 9.9 10.3 0.79 9.3 10.3 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) TRAP_alpha PF03896.16 ETO00859.1 - 0.56 9.4 7.5 1.1 8.4 7.5 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 ETO00859.1 - 1.7 7.9 7.2 2.7 7.2 7.2 1.2 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO00859.1 - 1.7 6.8 10.1 2.2 6.4 10.1 1.1 1 0 0 1 1 1 0 Nop14-like family Herpes_BLRF2 PF05812.12 ETO00860.1 - 0.0063 16.6 0.3 0.0084 16.2 0.3 1.2 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein Mce4_CUP1 PF11887.8 ETO00862.1 - 0.053 13.0 2.5 0.068 12.6 2.5 1.1 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative WD40 PF00400.32 ETO00864.1 - 2e-13 50.5 5.1 2e-06 28.4 0.7 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO00864.1 - 1.5e-05 25.2 0.1 0.0098 16.2 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO00864.1 - 0.00036 19.3 0.1 0.0006 18.6 0.1 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 CitMHS PF03600.16 ETO00865.1 - 9.3e-13 48.0 10.4 1.3e-12 47.6 10.4 1.2 1 0 0 1 1 1 1 Citrate transporter ArsB PF02040.15 ETO00865.1 - 1.2e-06 28.1 12.4 1.7e-06 27.7 12.4 1.1 1 0 0 1 1 1 1 Arsenical pump membrane protein LIF_OSM PF01291.17 ETO00867.1 - 0.0023 18.1 1.7 0.0023 18.1 1.7 2.5 2 1 0 2 2 2 1 LIF / OSM family FUSC PF04632.12 ETO00867.1 - 0.13 10.7 7.9 0.15 10.6 3.6 2.1 2 0 0 2 2 2 0 Fusaric acid resistance protein family Flagellin_C PF00700.21 ETO00867.1 - 0.23 11.8 7.1 0.44 10.9 0.2 2.7 2 1 0 2 2 2 0 Bacterial flagellin C-terminal helical region Golgin_A5 PF09787.9 ETO00867.1 - 0.82 9.1 37.5 0.48 9.8 8.3 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 DBD_HTH PF18430.1 ETO00867.1 - 1.3 8.8 10.9 3.5 7.5 2.2 3.1 2 1 0 2 2 2 0 Putative DNA-binding domain Fib_alpha PF08702.10 ETO00867.1 - 1.5 9.0 28.5 1.5 9.0 9.7 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 ETO00867.1 - 1.8 8.9 44.9 0.18 12.2 12.1 3.2 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 ETO00867.1 - 2 7.7 33.5 1.4 8.2 10.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Grg1 PF11034.8 ETO00867.1 - 5.5 7.3 18.9 2.7 8.3 2.1 3.0 3 0 0 3 3 3 0 Glucose-repressible protein Grg1 ApoB100_C PF12491.8 ETO00867.1 - 8.4 6.4 11.1 18 5.3 0.2 3.9 4 0 0 4 4 4 0 Apolipoprotein B100 C terminal zf-RanBP PF00641.18 ETO00868.1 - 4.8e-06 25.8 8.1 1.3e-05 24.3 8.1 1.8 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Kelch_4 PF13418.6 ETO00870.1 - 1.8e-07 31.0 0.5 3e-06 27.1 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO00870.1 - 3.1e-06 26.7 0.1 1.4e-05 24.6 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO00870.1 - 4.5e-05 23.6 2.8 0.0063 16.8 0.1 3.6 3 1 1 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO00870.1 - 0.0074 16.6 0.0 0.027 14.8 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO00870.1 - 0.016 15.2 0.8 0.44 10.6 0.5 2.9 3 0 0 3 3 3 0 Kelch motif DUF2415 PF10313.9 ETO00870.1 - 0.019 14.9 0.0 0.23 11.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) FRB_dom PF08771.11 ETO00872.1 - 0.031 14.7 0.8 0.14 12.6 0.1 2.4 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain INCENP_N PF12178.8 ETO00872.1 - 0.038 14.0 0.4 0.16 12.0 0.4 2.1 1 0 0 1 1 1 0 Chromosome passenger complex (CPC) protein INCENP N terminal Utp12 PF04003.12 ETO00872.1 - 0.12 12.7 1.7 0.55 10.6 1.7 2.1 1 0 0 1 1 1 0 Dip2/Utp12 Family CTK3 PF12243.8 ETO00872.1 - 0.16 12.0 0.1 0.16 12.0 0.1 3.5 4 0 0 4 4 4 0 CTD kinase subunit gamma CTK3 MRP-S23 PF10484.9 ETO00872.1 - 2.3 8.5 4.8 4.1 7.7 0.5 3.2 2 1 1 3 3 3 0 Mitochondrial ribosomal protein S23 INTS2 PF14750.6 ETO00873.1 - 0.07 10.7 0.8 0.075 10.6 0.8 1.1 1 0 0 1 1 1 0 Integrator complex subunit 2 WD40 PF00400.32 ETO00874.1 - 2.7e-06 28.0 2.8 5e-06 27.1 0.1 2.6 2 2 0 2 2 2 1 WD domain, G-beta repeat TPR_12 PF13424.6 ETO00875.1 - 0.00045 20.5 0.0 0.00069 19.9 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00875.1 - 0.012 15.8 1.0 0.19 12.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00875.1 - 0.014 15.4 0.1 2.1 8.6 0.0 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat RPN7 PF10602.9 ETO00875.1 - 0.014 15.1 0.1 0.017 14.8 0.1 1.3 1 0 0 1 1 1 0 26S proteasome subunit RPN7 TPR_10 PF13374.6 ETO00875.1 - 0.022 14.6 0.0 3.7 7.5 0.0 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00875.1 - 0.026 14.4 0.6 0.63 10.0 0.3 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat RVT_1 PF00078.27 ETO00876.1 - 6.1e-07 29.2 2.3 8.8e-07 28.7 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 ETO00876.1 - 0.0045 16.8 0.1 0.014 15.2 0.1 1.8 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase PHC2_SAM_assoc PF16616.5 ETO00877.1 - 0.95 10.3 12.1 4.8 8.0 12.1 2.0 1 1 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 GET2 PF08690.10 ETO00878.1 - 0.019 14.7 6.8 0.027 14.2 0.9 2.1 1 1 1 2 2 2 0 GET complex subunit GET2 PMT_4TMC PF16192.5 ETO00878.1 - 0.026 14.1 0.2 0.042 13.4 0.0 1.4 2 0 0 2 2 2 0 C-terminal four TMM region of protein-O-mannosyltransferase Exonuc_VII_L PF02601.15 ETO00879.1 - 0.0014 18.3 7.3 0.0016 18.1 7.3 1.2 1 0 0 1 1 1 1 Exonuclease VII, large subunit FapA PF03961.13 ETO00879.1 - 0.39 9.3 13.1 0.55 8.8 13.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3552 PF12072.8 ETO00879.1 - 0.63 9.4 33.7 1.5 8.2 33.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Kelch_6 PF13964.6 ETO00880.1 - 0.03 14.6 1.2 0.11 12.8 0.0 2.5 3 0 0 3 3 3 0 Kelch motif DUF4710 PF15828.5 ETO00881.1 - 0.057 13.5 1.2 1.8 8.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) COesterase PF00135.28 ETO00882.1 - 0.0022 17.0 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family DUF641 PF04859.12 ETO00884.1 - 0.0022 18.3 5.0 0.36 11.2 1.6 2.1 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) Bap31_Bap29_C PF18035.1 ETO00884.1 - 0.0024 17.8 13.9 0.18 11.8 5.1 2.1 2 0 0 2 2 2 2 Bap31/Bap29 cytoplasmic coiled-coil domain Csm1_N PF18504.1 ETO00884.1 - 0.0025 18.1 6.1 0.027 14.8 3.1 2.1 2 0 0 2 2 2 1 Csm1 N-terminal domain PKcGMP_CC PF16808.5 ETO00884.1 - 0.0054 16.6 11.1 0.0086 15.9 3.2 2.3 2 0 0 2 2 2 2 Coiled-coil N-terminus of cGMP-dependent protein kinase CC2-LZ PF16516.5 ETO00884.1 - 0.079 13.3 6.5 0.21 12.0 2.0 2.1 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Exo5 PF09810.9 ETO00884.1 - 0.26 10.7 4.0 0.28 10.6 4.0 1.0 1 0 0 1 1 1 0 Exonuclease V - a 5' deoxyribonuclease Geminin PF07412.12 ETO00884.1 - 0.31 10.8 7.6 0.65 9.7 0.3 2.1 2 0 0 2 2 2 0 Geminin DivIC PF04977.15 ETO00884.1 - 1.2 9.0 9.9 4.9 7.0 2.7 2.6 1 1 2 3 3 3 0 Septum formation initiator C4bp_oligo PF18453.1 ETO00884.1 - 1.4 9.1 7.3 1.5 9.1 0.6 3.0 3 0 0 3 3 3 0 Oligomerization domain of C4b-binding protein alpha DUF4201 PF13870.6 ETO00884.1 - 2.7 7.7 13.2 1.7 8.3 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) bZIP_1 PF00170.21 ETO00884.1 - 3.8 7.7 9.9 3.9 7.6 0.4 2.9 2 1 1 3 3 3 0 bZIP transcription factor CUE PF02845.16 ETO00885.1 - 0.03 14.0 0.0 0.065 13.0 0.0 1.6 1 0 0 1 1 1 0 CUE domain DUF4400 PF14348.6 ETO00887.1 - 0.048 13.2 0.1 0.083 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) DUF3892 PF13031.6 ETO00888.1 - 0.014 16.0 0.9 0.023 15.3 0.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3892) SBF2 PF12335.8 ETO00891.1 - 0.0016 18.1 2.8 0.0016 18.1 2.8 2.1 2 1 1 3 3 3 1 Myotubularin protein Pkinase PF00069.25 ETO00892.1 - 2.8e-20 72.8 0.1 3.4e-20 72.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00892.1 - 4e-11 42.7 0.0 4.7e-11 42.5 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO00892.1 - 0.14 11.5 0.2 0.18 11.1 0.2 1.1 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family eRF1_1 PF03463.15 ETO00893.1 - 3.4e-08 33.6 0.1 3e-05 24.0 0.0 2.1 1 1 1 2 2 2 2 eRF1 domain 1 eRF1_2 PF03464.15 ETO00893.1 - 0.003 17.9 0.0 0.0089 16.3 0.0 1.8 1 1 0 1 1 1 1 eRF1 domain 2 Ycf1 PF05758.12 ETO00895.1 - 0.014 13.3 10.7 0.016 13.1 10.7 1.1 1 0 0 1 1 1 0 Ycf1 OATP PF03137.20 ETO00895.1 - 0.019 13.3 1.0 0.022 13.1 1.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CPP1-like PF11833.8 ETO00895.1 - 0.041 13.5 0.3 0.05 13.3 0.3 1.2 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like CLN3 PF02487.17 ETO00895.1 - 0.095 11.7 1.1 0.099 11.7 1.1 1.1 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 ETO00895.1 - 0.12 11.9 8.8 0.13 11.7 8.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Ureide_permease PF07168.11 ETO00895.1 - 0.18 10.5 1.4 0.22 10.3 1.4 1.1 1 0 0 1 1 1 0 Ureide permease Connexin PF00029.19 ETO00895.1 - 0.5 10.1 5.9 0.65 9.7 5.9 1.2 1 0 0 1 1 1 0 Connexin SprA-related PF12118.8 ETO00895.1 - 0.68 9.0 7.3 0.82 8.8 7.3 1.1 1 0 0 1 1 1 0 SprA-related family PEX11 PF05648.14 ETO00895.1 - 0.91 8.9 7.1 2 7.8 7.1 1.6 1 1 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) Membralin PF09746.9 ETO00895.1 - 1.6 7.7 7.8 1.9 7.4 7.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein CCDC71L PF15374.6 ETO00895.1 - 2 7.6 13.5 2.5 7.3 13.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SPT2 PF08243.11 ETO00897.1 - 0.99 10.0 10.0 0.13 12.8 6.3 1.4 2 0 0 2 2 2 0 SPT2 chromatin protein EzrA PF06160.12 ETO00898.1 - 0.0056 14.9 1.6 0.0056 14.9 1.6 2.0 2 0 0 2 2 2 2 Septation ring formation regulator, EzrA DUF3802 PF12290.8 ETO00898.1 - 0.0083 16.6 0.2 0.094 13.2 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3802) JHBP PF06585.11 ETO00898.1 - 0.014 14.5 1.7 0.027 13.6 1.7 1.7 1 1 0 1 1 1 0 Haemolymph juvenile hormone binding protein (JHBP) Sec23_helical PF04815.15 ETO00898.1 - 0.058 13.2 0.3 9.1 6.2 0.0 2.1 1 1 1 2 2 2 0 Sec23/Sec24 helical domain Med4 PF10018.9 ETO00898.1 - 0.17 11.6 3.3 2.6 7.7 0.1 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 SpmSyn_N PF17950.1 ETO00898.1 - 0.53 10.5 4.1 17 5.7 0.1 2.8 2 1 1 3 3 3 0 S-adenosylmethionine decarboxylase N -terminal DUF16 PF01519.16 ETO00898.1 - 0.94 10.0 10.4 2.7 8.5 1.8 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 LMBR1 PF04791.16 ETO00898.1 - 1.9 7.3 4.2 4.3 6.1 4.2 1.6 1 1 0 1 1 1 0 LMBR1-like membrane protein CcmE PF03100.15 ETO00899.1 - 0.0065 16.5 0.2 0.0081 16.2 0.2 1.1 1 0 0 1 1 1 1 CcmE FliD_N PF02465.18 ETO00899.1 - 0.02 15.6 0.5 0.025 15.3 0.5 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus FERM_F1 PF18379.1 ETO00899.1 - 0.12 12.4 1.0 0.17 11.9 1.0 1.2 1 0 0 1 1 1 0 FERM F1 ubiquitin-like domain SUIM_assoc PF16619.5 ETO00899.1 - 0.15 12.2 7.7 0.2 11.7 7.7 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 SH3_10 PF17902.1 ETO00900.1 - 0.43 10.7 3.3 4.4 7.5 0.2 3.1 2 0 0 2 2 2 0 SH3 domain Nrap_D2 PF17403.2 ETO00901.1 - 0.17 11.7 1.7 0.42 10.4 0.1 2.0 1 1 0 2 2 2 0 Nrap protein PAP/OAS-like domain FapA PF03961.13 ETO00902.1 - 0.11 11.1 8.2 0.12 10.9 8.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Tmemb_cc2 PF10267.9 ETO00902.1 - 0.11 11.6 11.1 0.14 11.3 11.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Methyltrn_RNA_2 PF04013.12 ETO00902.1 - 0.15 11.7 0.9 0.19 11.4 0.9 1.2 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase PspB PF06667.12 ETO00902.1 - 1.3 9.2 4.0 1.1 9.3 2.0 1.9 2 0 0 2 2 2 0 Phage shock protein B DUF3443 PF11925.8 ETO00903.1 - 0.097 11.5 0.1 0.13 11.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3443) GLTSCR1 PF15249.6 ETO00904.1 - 0.0042 17.5 0.2 0.0042 17.5 0.2 3.6 3 0 0 3 3 3 1 Conserved region of unknown function on GLTSCR protein zf-TFIIIC PF12660.7 ETO00905.1 - 0.042 13.8 1.3 0.094 12.7 1.3 1.7 1 1 0 1 1 1 0 Putative zinc-finger of transcription factor IIIC complex Thr_synth_N PF14821.6 ETO00909.1 - 0.051 13.8 0.0 1.8 8.8 0.0 2.1 2 0 0 2 2 2 0 Threonine synthase N terminus Leo1 PF04004.13 ETO00909.1 - 0.066 13.0 0.0 0.073 12.9 0.0 1.2 1 0 0 1 1 1 0 Leo1-like protein XRN_M PF17846.1 ETO00910.1 - 1.5e-58 198.8 6.3 6.5e-58 196.7 3.6 2.0 1 1 1 2 2 2 2 Xrn1 helical domain RRP36 PF06102.12 ETO00910.1 - 0.032 14.2 0.5 0.046 13.7 0.5 1.1 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Lac_bphage_repr PF06543.12 ETO00912.1 - 3.7 7.6 7.4 5.1 7.2 2.3 2.8 1 1 2 3 3 3 0 Lactococcus bacteriophage repressor TMEM132 PF16070.5 ETO00913.1 - 2.5 7.4 5.5 5.5 6.2 4.3 1.8 1 1 1 2 2 2 0 Transmembrane protein family 132 ILEI PF15711.5 ETO00914.1 - 0.031 14.8 0.2 0.14 12.6 0.0 2.0 1 1 1 2 2 2 0 Interleukin-like EMT inducer RNA_pol_Rpb5_C PF01191.19 ETO00914.1 - 0.062 13.2 0.8 2.2 8.2 0.2 2.2 1 1 1 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Pkinase PF00069.25 ETO00915.1 - 2.5e-10 40.2 1.4 3.2e-10 39.8 1.4 1.1 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ETO00917.1 - 3e-13 50.0 6.6 5.7e-07 30.1 0.5 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO00917.1 - 7.9e-05 21.5 2.0 0.011 14.5 0.2 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00917.1 - 0.012 15.9 0.1 0.14 12.5 0.0 2.5 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Pox_E10 PF04805.12 ETO00920.1 - 0.032 14.1 0.8 0.05 13.5 0.2 1.7 1 1 0 1 1 1 0 E10-like protein conserved region AAA_18 PF13238.6 ETO00921.1 - 8.3e-06 26.4 0.5 8.3e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ETO00921.1 - 5.9e-05 23.1 0.0 0.00011 22.2 0.0 1.5 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ETO00921.1 - 0.00022 21.5 0.0 0.0011 19.3 0.0 1.9 1 1 1 2 2 2 1 AAA domain AAA_33 PF13671.6 ETO00921.1 - 0.0026 17.9 0.0 0.0056 16.8 0.0 1.6 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ETO00921.1 - 0.0028 17.7 0.0 0.0039 17.2 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_2 PF03668.15 ETO00921.1 - 0.0044 16.4 0.0 0.0064 15.8 0.0 1.3 1 0 0 1 1 1 1 P-loop ATPase protein family PRK PF00485.18 ETO00921.1 - 0.0071 16.1 0.1 0.013 15.2 0.0 1.5 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family RsgA_GTPase PF03193.16 ETO00921.1 - 0.0071 16.3 0.6 0.016 15.1 0.1 1.8 1 1 1 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 ETO00921.1 - 0.0093 16.3 3.5 0.02 15.3 0.1 2.2 2 1 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 ETO00921.1 - 0.011 15.8 0.0 0.016 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO00921.1 - 0.011 16.1 0.0 0.016 15.6 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain G-alpha PF00503.20 ETO00921.1 - 0.011 14.9 1.9 0.016 14.3 1.9 1.4 1 1 0 1 1 1 0 G-protein alpha subunit NB-ARC PF00931.22 ETO00921.1 - 0.022 13.9 0.1 0.038 13.2 0.1 1.4 1 1 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 ETO00921.1 - 0.035 13.8 0.0 0.043 13.5 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain KAP_NTPase PF07693.14 ETO00921.1 - 0.035 13.3 0.0 0.042 13.1 0.0 1.3 1 0 0 1 1 1 0 KAP family P-loop domain Torsin PF06309.11 ETO00921.1 - 0.042 14.0 0.1 0.074 13.2 0.1 1.4 1 1 0 1 1 1 0 Torsin PduV-EutP PF10662.9 ETO00921.1 - 0.046 13.5 0.0 0.1 12.3 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Zeta_toxin PF06414.12 ETO00921.1 - 0.054 12.8 0.0 0.069 12.4 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 ETO00921.1 - 0.066 12.9 0.1 0.24 11.1 0.0 2.0 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO00921.1 - 0.07 13.7 0.5 0.11 13.0 0.3 1.6 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 ETO00921.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO00921.1 - 0.15 11.8 0.0 0.24 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Cnd1 PF12717.7 ETO00922.1 - 1.9e-07 31.2 5.8 0.001 19.1 1.0 2.0 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Bac_DNA_binding PF00216.21 ETO00922.1 - 0.0029 17.8 0.9 0.03 14.5 0.7 2.2 2 1 0 2 2 2 1 Bacterial DNA-binding protein FliT PF05400.13 ETO00922.1 - 0.0041 17.9 0.9 0.0093 16.8 0.7 1.7 1 1 1 2 2 2 1 Flagellar protein FliT RP-C_C PF11800.8 ETO00922.1 - 0.0078 16.3 1.6 0.01 15.9 1.6 1.2 1 0 0 1 1 1 1 Replication protein C C-terminal region HEAT PF02985.22 ETO00922.1 - 0.008 16.4 0.1 0.045 14.0 0.0 2.3 2 1 0 2 2 2 1 HEAT repeat PRD PF00874.20 ETO00922.1 - 0.0087 16.3 1.2 0.019 15.2 1.2 1.7 2 0 0 2 2 1 1 PRD domain NYD-SP28 PF14772.6 ETO00922.1 - 0.018 15.1 3.6 0.018 15.1 3.6 2.5 3 0 0 3 3 3 0 Sperm tail Baculo_PEP_C PF04513.12 ETO00922.1 - 0.037 14.1 2.2 0.29 11.1 2.2 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HSBP1 PF06825.12 ETO00922.1 - 0.041 13.7 1.2 0.1 12.5 0.5 2.0 2 0 0 2 2 2 0 Heat shock factor binding protein 1 HEAT_2 PF13646.6 ETO00922.1 - 0.058 13.8 0.0 0.093 13.1 0.0 1.3 1 0 0 1 1 1 0 HEAT repeats DUF4279 PF14106.6 ETO00922.1 - 0.068 13.4 2.8 0.16 12.2 1.7 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4279) PqqD PF05402.12 ETO00922.1 - 0.071 13.4 2.1 1.8 8.9 0.1 3.0 4 0 0 4 4 4 0 Coenzyme PQQ synthesis protein D (PqqD) PAS_10 PF13596.6 ETO00922.1 - 0.11 13.1 1.0 1.1 9.8 0.1 2.3 1 1 1 2 2 2 0 PAS domain DUF4446 PF14584.6 ETO00922.1 - 0.98 9.4 5.2 0.7 9.9 2.0 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) DUF4247 PF14042.6 ETO00925.1 - 7.4 7.3 8.0 1.7 9.3 3.6 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4247) Kelch_6 PF13964.6 ETO00926.1 - 0.62 10.4 2.2 0.59 10.5 0.6 1.8 2 0 0 2 2 2 0 Kelch motif AAA_22 PF13401.6 ETO00927.1 - 0.001 19.4 0.2 0.0027 18.0 0.1 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO00927.1 - 0.015 15.7 0.0 0.031 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 ETO00927.1 - 0.031 14.0 0.5 0.096 12.4 0.4 1.8 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ETO00927.1 - 0.053 14.0 0.4 0.15 12.5 0.4 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO00927.1 - 0.063 12.8 0.6 0.25 10.9 0.6 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region NACHT PF05729.12 ETO00927.1 - 0.084 12.8 0.2 0.14 12.0 0.2 1.6 1 1 0 1 1 1 0 NACHT domain OST-HTH PF12872.7 ETO00927.1 - 0.2 11.5 0.9 0.43 10.4 0.2 1.9 2 0 0 2 2 2 0 OST-HTH/LOTUS domain Spc7_N PF15402.6 ETO00928.1 - 0.017 13.4 4.0 0.019 13.3 4.0 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 DUF1400 PF07176.11 ETO00928.1 - 0.039 14.2 0.2 0.05 13.9 0.2 1.4 1 1 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1400) SSPI PF14098.6 ETO00928.1 - 0.25 11.5 0.4 0.25 11.5 0.4 2.6 3 0 0 3 3 3 0 Small, acid-soluble spore protein I TPR_12 PF13424.6 ETO00929.1 - 5.5e-84 276.5 33.7 5.3e-20 71.5 0.8 5.3 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO00929.1 - 8.7e-50 165.3 10.6 9.8e-10 38.0 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO00929.1 - 4.1e-48 159.3 60.1 2.9e-09 36.4 1.9 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO00929.1 - 1.5e-42 140.3 50.2 1.1e-07 31.4 0.9 7.8 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO00929.1 - 1.4e-39 131.0 52.4 4.5e-07 29.6 1.3 7.8 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO00929.1 - 2.4e-37 124.2 16.7 8e-05 22.4 0.1 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO00929.1 - 4.6e-26 89.3 0.1 0.01 16.6 0.0 7.2 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO00929.1 - 1.4e-23 83.2 0.4 4.9e-06 27.1 0.0 5.4 3 3 1 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO00929.1 - 1.3e-22 78.8 15.6 0.0075 16.8 0.0 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO00929.1 - 1e-17 63.5 49.7 9.4e-05 22.0 0.5 8.7 8 2 2 10 10 10 5 TPR repeat SNAP PF14938.6 ETO00929.1 - 1.3e-16 60.9 20.2 3.5e-07 29.9 2.0 3.3 1 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO00929.1 - 1.4e-15 56.5 24.5 0.0034 17.6 0.9 7.7 7 3 0 7 7 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO00929.1 - 8.9e-12 45.1 34.6 0.00076 19.7 5.0 6.0 1 1 5 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO00929.1 - 1.1e-10 40.7 10.7 0.4 10.2 0.0 7.4 8 0 0 8 8 8 3 SHNi-TPR TPR_19 PF14559.6 ETO00929.1 - 3.4e-10 40.3 12.3 0.0046 17.4 0.2 5.9 4 2 2 6 6 6 3 Tetratricopeptide repeat MIT PF04212.18 ETO00929.1 - 2.1e-09 37.3 33.2 0.49 10.5 0.6 7.3 7 0 0 7 7 7 4 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETO00929.1 - 2e-07 30.8 0.0 0.0021 17.5 0.1 2.9 1 1 2 3 3 3 2 MalT-like TPR region TPR_3 PF07720.12 ETO00929.1 - 4.7e-07 29.7 42.6 0.018 15.1 0.9 7.0 7 0 0 7 7 7 4 Tetratricopeptide repeat DUF2225 PF09986.9 ETO00929.1 - 1.7e-06 28.0 28.8 0.054 13.2 2.9 4.1 1 1 1 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) HTH_Bact PF18768.1 ETO00929.1 - 1.2e-05 24.7 12.5 5.3 6.7 0.2 6.7 6 1 1 7 7 6 0 Helix-turn-helix bacterial domain Sel1 PF08238.12 ETO00929.1 - 2.5e-05 24.8 29.3 1.9 9.3 0.2 8.4 8 2 0 8 8 7 1 Sel1 repeat PPR PF01535.20 ETO00929.1 - 7.5e-05 22.7 11.3 0.46 10.9 0.1 6.5 7 1 0 7 7 7 2 PPR repeat ATP-synt_E_2 PF08112.11 ETO00929.1 - 0.00095 19.4 11.3 11 6.3 0.0 6.4 6 1 1 7 7 6 0 ATP synthase epsilon subunit DUF5113 PF17140.4 ETO00929.1 - 0.00096 19.0 30.7 0.27 11.0 0.5 6.4 4 3 2 6 6 6 1 Domain of unknown function (DUF5113) SMBP PF16785.5 ETO00929.1 - 0.0037 17.5 6.8 9.6 6.5 0.0 4.8 5 1 0 5 5 4 0 Small metal-binding protein TPR_21 PF09976.9 ETO00929.1 - 0.0052 16.5 12.1 0.44 10.2 4.0 3.9 1 1 1 3 3 3 2 Tetratricopeptide repeat-like domain DUF5601 PF18151.1 ETO00929.1 - 0.0063 16.8 0.3 9.6 6.6 0.0 3.3 4 1 0 4 4 3 0 Domain of unknown function (DUF5601) VWA_2 PF13519.6 ETO00929.1 - 0.0065 17.1 0.1 6.4 7.5 0.0 3.6 2 2 2 4 4 4 0 von Willebrand factor type A domain NSF PF02071.20 ETO00929.1 - 0.0065 17.0 31.8 30 6.0 0.1 8.9 8 0 0 8 8 8 0 Aromatic-di-Alanine (AdAR) repeat DUF627 PF04781.12 ETO00929.1 - 0.0067 16.4 14.1 6 6.9 0.0 5.9 2 1 2 5 5 5 0 Protein of unknown function (DUF627) TPR_5 PF12688.7 ETO00929.1 - 0.017 15.4 1.6 1.7 8.9 0.0 4.3 3 2 1 5 5 5 0 Tetratrico peptide repeat DUF424 PF04242.13 ETO00929.1 - 0.02 15.2 2.9 8.9 6.7 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF424) RPN7 PF10602.9 ETO00929.1 - 0.041 13.6 22.3 0.49 10.1 2.9 5.4 2 2 3 5 5 5 0 26S proteasome subunit RPN7 Mistic PF11458.8 ETO00929.1 - 0.08 12.9 13.7 18 5.4 0.3 5.9 5 1 1 6 6 6 0 Membrane-integrating protein Mistic TEX29 PF15839.5 ETO00929.1 - 0.096 13.3 0.5 9.5 6.9 0.1 4.0 2 1 3 5 5 4 0 Testis-expressed sequence 29 protein Mg-por_mtran_C PF07109.11 ETO00929.1 - 0.11 12.9 0.4 0.46 10.9 0.1 2.1 2 0 0 2 2 2 0 Magnesium-protoporphyrin IX methyltransferase C-terminus DUF2753 PF10952.8 ETO00929.1 - 0.12 12.5 2.4 37 4.5 0.1 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2753) DUF3856 PF12968.7 ETO00929.1 - 0.13 12.4 8.5 6.3 6.9 0.5 3.9 1 1 0 3 3 3 0 Domain of Unknown Function (DUF3856) TetR_C_19 PF17924.1 ETO00929.1 - 0.18 12.4 13.5 30 5.2 0.1 5.3 5 0 0 5 5 5 0 Tetracyclin repressor-like, C-terminal domain UPF0262 PF06793.12 ETO00929.1 - 0.22 11.6 3.9 0.65 10.1 0.1 2.9 1 1 3 4 4 4 0 Uncharacterised protein family (UPF0262) Ubiq_cyt_C_chap PF03981.12 ETO00929.1 - 0.26 11.4 1.8 5.6 7.0 0.1 3.6 1 1 2 4 4 4 0 Ubiquinol-cytochrome C chaperone Vps39_1 PF10366.9 ETO00929.1 - 2 8.7 16.9 7 7.0 0.5 5.4 1 1 3 5 5 5 0 Vacuolar sorting protein 39 domain 1 Sda PF08970.10 ETO00929.1 - 2.5 7.9 16.1 32 4.4 0.0 6.4 7 0 0 7 7 7 0 Sporulation inhibitor A UVR PF02151.19 ETO00929.1 - 3.4 7.5 14.4 16 5.4 0.1 5.9 7 0 0 7 7 6 0 UvrB/uvrC motif Prefoldin PF02996.17 ETO00929.1 - 7.1 6.6 12.7 6.7 6.6 0.0 4.7 6 0 0 6 6 6 0 Prefoldin subunit DHC_N1 PF08385.12 ETO00931.1 - 7.5e-20 71.1 0.1 1.3e-19 70.2 0.1 1.5 1 1 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DUF3439 PF11921.8 ETO00931.1 - 0.46 10.5 4.6 0.73 9.8 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 ETO00934.1 - 2e-17 63.5 1.0 3.5e-17 62.6 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO00934.1 - 1.6e-16 60.4 0.0 3.8e-16 59.1 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO00934.1 - 1.5e-06 27.7 0.0 3.7e-06 26.5 0.0 1.6 1 0 0 1 1 1 1 Kinase-like SUIM_assoc PF16619.5 ETO00934.1 - 0.0047 17.0 9.7 0.0098 15.9 9.7 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 PIP49_C PF12260.8 ETO00934.1 - 0.0061 16.2 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein-kinase domain of FAM69 Phage_Gp23 PF10669.9 ETO00935.1 - 0.53 10.6 6.9 1.7 9.0 6.9 1.8 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) PWWP PF00855.17 ETO00936.1 - 4.7e-07 30.1 4.9 5.3e-07 29.9 0.5 2.3 2 0 0 2 2 2 1 PWWP domain DUF4551 PF15087.6 ETO00936.1 - 0.2 10.5 2.1 0.24 10.2 2.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) EAP30 PF04157.16 ETO00938.1 - 0.0036 16.6 0.5 0.0036 16.6 0.5 2.7 2 1 0 2 2 2 1 EAP30/Vps36 family Cytochrom_C_2 PF01322.20 ETO00938.1 - 0.1 13.5 4.6 0.11 13.3 0.9 2.3 2 0 0 2 2 2 0 Cytochrome C' Abhydrolase_4 PF08386.10 ETO00938.1 - 0.18 12.0 1.0 0.64 10.2 0.1 2.3 2 2 2 4 4 4 0 TAP-like protein LUC7 PF03194.15 ETO00938.1 - 0.34 10.6 17.3 0.022 14.5 7.2 2.2 2 0 0 2 2 2 0 LUC7 N_terminus PilJ PF13675.6 ETO00938.1 - 0.34 10.9 9.2 0.29 11.2 4.6 2.2 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term FUSC PF04632.12 ETO00938.1 - 0.53 8.8 2.9 0.81 8.1 2.9 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family TolA_bind_tri PF16331.5 ETO00938.1 - 2 8.5 22.4 0.059 13.5 10.2 3.2 2 1 1 3 3 3 0 TolA binding protein trimerisation DUF2203 PF09969.9 ETO00938.1 - 2.6 8.8 15.2 5.3 7.8 0.7 3.1 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF4407 PF14362.6 ETO00938.1 - 4.2 6.6 13.7 5.7 6.2 6.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Cnd1 PF12717.7 ETO00939.1 - 0.00085 19.4 2.4 0.0017 18.4 1.1 2.1 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 NLE PF08154.12 ETO00939.1 - 0.0033 17.9 2.4 0.26 11.8 0.0 3.6 2 1 1 3 3 3 1 NLE (NUC135) domain RTP1_C1 PF10363.9 ETO00939.1 - 0.0052 17.0 0.4 0.11 12.7 0.2 2.7 2 1 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 TIP120 PF08623.10 ETO00939.1 - 0.017 14.9 0.3 5.1 6.8 0.1 2.5 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) Arm-DNA-bind_2 PF12167.8 ETO00939.1 - 0.03 14.2 0.0 0.51 10.3 0.0 2.7 3 0 0 3 3 3 0 Arm DNA-binding domain FANCI_S1 PF14675.6 ETO00939.1 - 0.06 12.9 2.6 0.36 10.4 0.3 2.1 1 1 0 2 2 2 0 FANCI solenoid 1 DSHCT PF08148.12 ETO00939.1 - 0.067 12.9 0.2 0.21 11.2 0.2 1.9 1 1 0 1 1 1 0 DSHCT (NUC185) domain CCDC-167 PF15188.6 ETO00939.1 - 0.23 11.8 2.8 7.7 6.9 0.4 3.2 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 FPL PF09758.9 ETO00939.1 - 0.84 9.6 5.6 2.7 8.0 0.6 3.4 2 2 0 2 2 2 0 Uncharacterised conserved protein zf-AD PF07776.15 ETO00941.1 - 0.16 12.2 2.0 0.2 11.9 0.1 2.1 1 1 0 2 2 2 0 Zinc-finger associated domain (zf-AD) Endonuclease_NS PF01223.23 ETO00942.1 - 9.4e-35 120.5 3.7 2.5e-28 99.4 0.2 2.7 2 1 1 3 3 3 2 DNA/RNA non-specific endonuclease CCDC142 PF14923.6 ETO00943.1 - 0.0076 15.0 0.2 0.0083 14.9 0.2 1.2 1 0 0 1 1 1 1 Coiled-coil protein 142 WD40 PF00400.32 ETO00944.1 - 8.1e-07 29.7 0.1 0.00045 21.0 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO00944.1 - 0.0073 16.3 0.0 0.011 15.7 0.0 1.3 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ETO00944.1 - 0.011 14.4 0.0 0.012 14.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Connexin PF00029.19 ETO00945.1 - 1.5 8.5 5.8 1.7 8.4 5.8 1.1 1 0 0 1 1 1 0 Connexin RNA_ligase PF09414.10 ETO00947.1 - 0.0027 18.0 0.0 0.0034 17.7 0.0 1.2 1 0 0 1 1 1 1 RNA ligase Peptidase_C14 PF00656.22 ETO00948.1 - 8.5e-13 48.8 0.2 1e-12 48.5 0.2 1.1 1 0 0 1 1 1 1 Caspase domain zf-TRAF PF02176.18 ETO00950.1 - 3.4e-08 34.0 2.6 1.3e-07 32.2 2.6 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger TMEM43 PF07787.12 ETO00950.1 - 0.12 11.8 0.0 0.18 11.2 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 Nodulin_late PF07127.11 ETO00952.1 - 0.075 13.4 7.3 4.9 7.6 7.3 2.2 1 1 0 1 1 1 0 Late nodulin protein MT PF12777.7 ETO00953.1 - 6.9e-09 35.2 0.2 8e-09 35.0 0.2 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor DUF4201 PF13870.6 ETO00953.1 - 0.00081 19.2 5.3 0.0013 18.5 5.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4201) Tropomyosin PF00261.20 ETO00953.1 - 0.0058 16.0 4.0 0.0083 15.5 3.8 1.4 1 1 0 1 1 1 1 Tropomyosin Perilipin PF03036.16 ETO00953.1 - 0.0076 15.3 3.8 0.0088 15.1 3.8 1.1 1 0 0 1 1 1 1 Perilipin family RmuC PF02646.16 ETO00953.1 - 0.0088 15.2 3.9 0.013 14.6 3.9 1.4 1 0 0 1 1 1 1 RmuC family Rho_Binding PF08912.11 ETO00953.1 - 0.012 16.4 1.4 0.012 16.4 1.4 2.8 2 1 1 3 3 3 0 Rho Binding Laminin_II PF06009.12 ETO00953.1 - 0.013 15.5 4.3 0.013 15.5 4.3 1.7 1 1 1 2 2 2 0 Laminin Domain II ABC_tran_CTD PF16326.5 ETO00953.1 - 0.015 15.5 0.3 0.015 15.5 0.3 2.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF812 PF05667.11 ETO00953.1 - 0.017 14.1 5.2 0.024 13.6 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) CENP-F_leu_zip PF10473.9 ETO00953.1 - 0.018 15.1 6.2 0.045 13.8 6.2 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO00953.1 - 0.019 13.9 6.0 0.022 13.6 6.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein TolA_bind_tri PF16331.5 ETO00953.1 - 0.024 14.7 1.0 0.024 14.7 1.0 1.9 2 1 0 2 2 2 0 TolA binding protein trimerisation TMF_TATA_bd PF12325.8 ETO00953.1 - 0.031 14.5 5.2 0.06 13.6 5.2 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.10 ETO00953.1 - 0.047 13.9 6.3 0.057 13.6 1.2 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 ETO00953.1 - 0.051 13.6 4.5 0.098 12.7 3.4 1.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Occludin_ELL PF07303.13 ETO00953.1 - 0.052 14.3 1.8 0.14 12.9 1.5 1.9 1 1 1 2 2 2 0 Occludin homology domain KxDL PF10241.9 ETO00953.1 - 0.053 13.8 0.8 0.053 13.8 0.8 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein Swi5 PF07061.11 ETO00953.1 - 0.061 13.4 0.5 0.061 13.4 0.5 2.4 3 0 0 3 3 2 0 Swi5 DUF1664 PF07889.12 ETO00953.1 - 0.064 13.3 2.7 0.044 13.8 1.1 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF1664) TFR_dimer PF04253.15 ETO00953.1 - 0.076 13.1 0.5 0.37 10.9 0.3 2.1 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain Mce4_CUP1 PF11887.8 ETO00953.1 - 0.077 12.4 0.4 0.11 11.9 0.4 1.2 1 0 0 1 1 1 0 Cholesterol uptake porter CUP1 of Mce4, putative Phage_GPO PF05929.11 ETO00953.1 - 0.086 12.4 3.4 0.26 10.9 3.4 1.7 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase SesA PF17107.5 ETO00953.1 - 0.11 12.7 6.5 0.16 12.2 1.9 2.1 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Tropomyosin_1 PF12718.7 ETO00953.1 - 0.11 12.7 8.0 0.34 11.1 5.7 2.2 1 1 1 2 2 2 0 Tropomyosin like DASH_Dam1 PF08653.10 ETO00953.1 - 0.11 12.3 2.5 1 9.2 0.6 2.8 2 1 1 3 3 3 0 DASH complex subunit Dam1 DUF724 PF05266.14 ETO00953.1 - 0.12 12.2 4.1 0.087 12.6 2.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Focal_AT PF03623.13 ETO00953.1 - 0.12 12.3 3.8 0.2 11.7 2.6 1.8 1 1 1 2 2 2 0 Focal adhesion targeting region TPR_MLP1_2 PF07926.12 ETO00953.1 - 0.13 12.3 6.5 0.15 12.1 1.8 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 ETO00953.1 - 0.14 11.9 4.0 0.13 12.0 2.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF745) DUF4806 PF16064.5 ETO00953.1 - 0.17 12.2 2.3 0.77 10.1 1.0 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4806) DASH_Duo1 PF08651.10 ETO00953.1 - 0.19 11.5 4.9 0.58 10.0 1.6 2.4 1 1 1 2 2 2 0 DASH complex subunit Duo1 FliJ PF02050.16 ETO00953.1 - 0.22 11.7 6.0 0.061 13.5 2.6 1.7 2 0 0 2 2 2 0 Flagellar FliJ protein FlgN PF05130.12 ETO00953.1 - 0.23 11.9 7.7 0.062 13.8 4.0 1.8 2 0 0 2 2 2 0 FlgN protein FlaC_arch PF05377.11 ETO00953.1 - 0.24 11.8 6.3 0.43 11.0 1.3 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) FapA PF03961.13 ETO00953.1 - 0.26 9.9 4.8 0.28 9.8 4.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF948 PF06103.11 ETO00953.1 - 0.31 11.3 3.6 0.6 10.4 2.4 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PCRF PF03462.18 ETO00953.1 - 0.39 10.6 4.1 1.1 9.1 4.1 1.7 1 1 0 1 1 1 0 PCRF domain Hrs_helical PF12210.8 ETO00953.1 - 0.48 11.0 7.4 2.7 8.6 0.5 2.5 2 1 1 3 3 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DUF16 PF01519.16 ETO00953.1 - 0.61 10.6 6.6 1.2 9.6 6.6 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 YabA PF06156.13 ETO00953.1 - 0.66 10.6 6.9 0.36 11.5 4.4 1.9 2 1 0 2 2 1 0 Initiation control protein YabA Seryl_tRNA_N PF02403.22 ETO00953.1 - 0.87 9.9 6.4 1.5 9.1 4.7 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain JIP_LZII PF16471.5 ETO00953.1 - 2.4 8.4 10.8 3.7 7.8 1.1 2.9 2 1 0 3 3 3 0 JNK-interacting protein leucine zipper II TMF_DNA_bd PF12329.8 ETO00953.1 - 2.7 8.1 10.1 0.53 10.3 6.1 1.9 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BST2 PF16716.5 ETO00953.1 - 2.7 8.6 12.7 2 9.0 6.4 2.6 2 1 1 3 3 2 0 Bone marrow stromal antigen 2 Uso1_p115_C PF04871.13 ETO00953.1 - 4 7.8 8.3 1.8 8.9 1.2 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Prefoldin_2 PF01920.20 ETO00953.1 - 4.4 7.3 11.9 0.87 9.6 1.2 2.7 2 1 1 3 3 3 0 Prefoldin subunit Prefoldin PF02996.17 ETO00953.1 - 4.6 7.2 9.0 1.2 9.1 0.9 2.5 2 1 2 4 4 3 0 Prefoldin subunit Lipoprotein_9 PF03180.14 ETO00956.1 - 0.0084 15.2 0.3 0.0096 15.1 0.3 1.1 1 0 0 1 1 1 1 NLPA lipoprotein DUF1816 PF08846.10 ETO00957.1 - 0.069 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1816) Cep57_CLD_2 PF14197.6 ETO00957.1 - 0.12 12.5 15.9 0.45 10.6 8.0 2.9 1 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Ax_dynein_light PF10211.9 ETO00957.1 - 3.7 7.5 14.4 20 5.1 14.3 2.0 1 1 0 1 1 1 0 Axonemal dynein light chain Uso1_p115_C PF04871.13 ETO00957.1 - 6.6 7.1 14.4 1.5 9.2 9.7 1.9 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region AAA_5 PF07728.14 ETO00958.1 - 0.0082 16.2 0.0 0.66 10.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO00958.1 - 0.029 13.9 0.3 0.13 11.8 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 ETO00958.1 - 0.044 14.2 0.4 0.26 11.7 0.0 2.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO00958.1 - 0.069 13.4 0.1 1.6 9.0 0.0 3.3 3 1 0 3 3 3 0 AAA domain Med4 PF10018.9 ETO00959.1 - 0.011 15.4 2.2 0.014 15.1 2.2 1.2 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Paramyxo_P PF01806.17 ETO00959.1 - 0.011 15.2 0.9 0.013 15.0 0.9 1.0 1 0 0 1 1 1 0 Paramyxovirinae P phosphoprotein C-terminal region dUTPase_2 PF08761.11 ETO00960.1 - 0.0078 16.4 1.4 0.41 10.8 0.2 2.1 1 1 1 2 2 2 2 dUTPase DUF502 PF04367.13 ETO00960.1 - 0.0088 15.9 0.0 2.6 8.0 0.0 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF502) DUF1048 PF06304.11 ETO00961.1 - 0.00072 20.0 0.1 0.0039 17.6 0.1 2.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1048) DUF1548 PF07579.11 ETO00961.1 - 0.004 17.5 4.1 0.004 17.5 4.1 3.7 4 0 0 4 4 4 1 Domain of Unknown Function (DUF1548) Nup54_C PF18437.1 ETO00962.1 - 0.00058 19.7 6.8 0.87 9.5 0.3 4.0 3 0 0 3 3 3 2 Nup54 C-terminal interacting domain TMF_DNA_bd PF12329.8 ETO00962.1 - 0.0076 16.2 137.8 0.59 10.2 16.6 8.6 1 1 5 8 8 8 6 TATA element modulatory factor 1 DNA binding KASH_CCD PF14662.6 ETO00962.1 - 0.055 13.3 129.6 0.47 10.3 28.8 5.2 1 1 4 5 5 5 0 Coiled-coil region of CCDC155 or KASH APG6_N PF17675.1 ETO00962.1 - 0.057 13.9 124.4 0.31 11.6 22.0 5.4 1 1 4 5 5 5 0 Apg6 coiled-coil region DUF16 PF01519.16 ETO00962.1 - 0.13 12.7 121.2 0.11 13.0 15.6 8.4 1 1 7 8 8 8 0 Protein of unknown function DUF16 TPR_MLP1_2 PF07926.12 ETO00962.1 - 5.9 7.0 117.5 0.3 11.2 25.2 6.4 1 1 7 8 8 8 0 TPR/MLP1/MLP2-like protein NACHT PF05729.12 ETO00966.1 - 0.0057 16.6 0.0 0.013 15.4 0.0 1.6 1 1 0 1 1 1 1 NACHT domain ESP PF16590.5 ETO00966.1 - 0.093 13.0 1.2 0.27 11.5 0.9 2.0 1 1 0 1 1 1 0 Exocrine gland-secreting peptide GIT_CC PF16559.5 ETO00967.1 - 0.0027 17.5 2.2 0.0027 17.5 2.2 6.2 5 1 3 8 8 8 1 GIT coiled-coil Rho guanine nucleotide exchange factor Fungal_TACC PF12709.7 ETO00967.1 - 0.0084 16.5 7.0 0.0084 16.5 7.0 8.6 3 1 5 9 9 9 1 Fungal Transforming acidic coiled-coil (TACC) proteins Filament PF00038.21 ETO00967.1 - 0.01 15.4 10.3 0.01 15.4 10.3 3.9 1 1 3 4 4 4 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 ETO00967.1 - 0.14 12.2 77.8 0.42 10.7 8.9 5.7 1 1 5 6 6 6 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 ETO00967.1 - 2.3 7.5 61.4 0.81 8.9 7.9 5.3 2 1 2 5 5 5 0 Protein of unknown function (DUF3450) ATG16 PF08614.11 ETO00967.1 - 2.8 8.1 85.0 0.042 14.1 26.4 5.8 3 1 3 6 6 6 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.11 ETO00967.1 - 3.3 6.5 82.3 0.055 12.3 27.5 3.1 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like FUSC PF04632.12 ETO00967.1 - 7.5 5.0 6.3 8.1 4.8 4.6 1.6 1 1 1 2 2 2 0 Fusaric acid resistance protein family MIEAP PF16026.5 ETO00968.1 - 6e-09 36.4 3.5 6e-09 36.4 3.5 3.2 1 1 1 2 2 2 1 Mitochondria-eating protein HD_3 PF13023.6 ETO00968.1 - 0.0095 15.9 0.8 0.0095 15.9 0.8 2.8 3 1 0 3 3 3 1 HD domain MHC_II_beta PF00969.19 ETO00970.1 - 0.016 15.3 0.3 1.2 9.3 0.0 3.1 3 0 0 3 3 3 0 Class II histocompatibility antigen, beta domain Nbl1_Borealin_N PF10444.9 ETO00970.1 - 0.042 13.5 2.8 0.44 10.2 0.5 2.9 2 1 0 2 2 2 0 Nbl1 / Borealin N terminal Alliinase_C PF04864.13 ETO00970.1 - 0.048 12.5 0.4 0.32 9.8 0.4 2.0 1 1 0 1 1 1 0 Allinase TBCA PF02970.16 ETO00970.1 - 0.079 13.3 4.2 6.5 7.2 0.7 3.5 2 2 0 2 2 2 0 Tubulin binding cofactor A TBCC_N PF16752.5 ETO00970.1 - 0.15 12.6 4.3 0.11 13.0 0.8 2.5 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Neuropep_like PF15161.6 ETO00970.1 - 0.16 11.7 0.0 1 9.0 0.0 2.3 2 0 0 2 2 2 0 Neuropeptide-like DUF4363 PF14276.6 ETO00970.1 - 0.42 10.7 5.1 0.22 11.7 0.3 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4363) CHIP_TPR_N PF18391.1 ETO00970.1 - 4.6 8.1 8.0 3.9 8.3 0.8 3.3 2 2 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain BTHB PF18410.1 ETO00974.1 - 0.059 13.2 0.2 0.099 12.5 0.2 1.4 1 0 0 1 1 1 0 Basic tilted helix bundle domain Csm2_III-A PF03750.13 ETO00975.1 - 0.11 13.3 3.7 2.5 9.0 0.4 2.2 2 0 0 2 2 2 0 Csm2 Type III-A DUF2722 PF10846.8 ETO00976.1 - 1.5 7.7 12.2 1.6 7.6 12.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pelovaterin PF17859.1 ETO00978.1 - 0.13 12.6 0.4 0.26 11.6 0.4 1.4 1 0 0 1 1 1 0 Pelovaterin DUF5532 PF17673.1 ETO00979.1 - 0.053 13.6 1.9 0.15 12.1 1.6 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5532) DUF3730 PF12530.8 ETO00979.1 - 0.066 12.8 0.2 0.099 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) Pyr_redox_dim PF02852.22 ETO00980.1 - 0.00025 21.3 0.0 0.00049 20.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Cupin_4 PF08007.12 ETO00982.1 - 7.9e-18 65.0 0.1 1.9e-17 63.7 0.1 1.6 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 ETO00982.1 - 2.4e-07 30.8 1.4 3e-06 27.2 1.4 2.5 1 1 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ETO00982.1 - 0.0019 18.6 0.4 0.01 16.3 0.1 2.4 1 1 1 2 2 2 1 JmjC domain, hydroxylase SpoIIP PF07454.11 ETO00982.1 - 0.47 9.9 5.7 0.045 13.2 1.3 1.5 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) BCIP PF13862.6 ETO00982.1 - 0.82 9.4 5.2 0.19 11.5 1.3 1.8 2 0 0 2 2 2 0 p21-C-terminal region-binding protein RNase_H PF00075.24 ETO00983.1 - 2.3e-17 63.5 0.0 6e-17 62.2 0.0 1.6 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETO00983.1 - 9.3e-07 28.7 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase-like RVT_1 PF00078.27 ETO00983.1 - 0.025 14.1 0.1 0.091 12.3 0.0 2.0 2 0 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) KicB PF03882.14 ETO00985.1 - 0.13 12.5 0.5 6.6 7.0 0.1 2.5 2 1 0 2 2 2 0 MukF winged-helix domain TSR PF18487.1 ETO00985.1 - 0.19 12.0 2.1 23 5.3 0.1 3.1 3 0 0 3 3 3 0 Thrombospondin type 1 repeat Nup160 PF11715.8 ETO00986.1 - 0.015 14.0 0.0 0.015 14.0 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO00986.1 - 0.035 15.0 0.1 2 9.4 0.0 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat Mad3_BUB1_I PF08311.12 ETO00987.1 - 0.027 14.5 0.9 0.18 11.8 0.1 2.1 2 0 0 2 2 2 0 Mad3/BUB1 homology region 1 Cu_bind_like PF02298.17 ETO00987.1 - 0.061 13.3 0.2 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 Plastocyanin-like domain CRIM PF16978.5 ETO00988.1 - 0.0063 16.7 0.1 0.011 15.9 0.1 1.4 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain QRPTase_C PF01729.19 ETO00989.1 - 0.12 12.2 0.6 0.15 11.9 0.6 1.2 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain DUF604 PF04646.12 ETO00989.1 - 0.35 10.2 5.1 0.37 10.2 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF604 CiPC PF15800.5 ETO00990.1 - 0.016 14.9 0.3 0.018 14.8 0.3 1.2 1 0 0 1 1 1 0 Clock interacting protein circadian Com_YlbF PF06133.11 ETO00990.1 - 3.7 8.2 10.2 0.91 10.2 4.8 2.0 1 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA ANAPC15 PF15243.6 ETO00991.1 - 0.0056 17.1 8.9 0.01 16.2 3.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 15 Herpes_UL32 PF06070.11 ETO00991.1 - 4.2 5.0 8.2 0.11 10.3 1.8 1.4 2 0 0 2 2 2 0 Herpesvirus large structural phosphoprotein UL32 Tubulin_C PF03953.17 ETO00992.1 - 3.8e-16 59.4 0.2 5.8e-16 58.8 0.2 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain FAD_binding_8 PF08022.12 ETO00993.1 - 3.9e-18 65.5 0.0 5.4e-18 65.1 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 ETO00993.1 - 0.063 13.6 0.0 0.092 13.1 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain Ssl1 PF04056.14 ETO00994.1 - 0.13 12.1 0.1 0.24 11.2 0.1 1.4 1 0 0 1 1 1 0 Ssl1-like Tubulin_C PF03953.17 ETO00995.1 - 1.3e-13 51.2 0.1 1.8e-13 50.8 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain HA70_C PF17993.1 ETO00995.1 - 0.11 12.6 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Haemagglutinin 70 C-terminal domain FAD_binding_8 PF08022.12 ETO00996.1 - 1.4e-23 83.1 0.0 2.3e-23 82.3 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ETO00996.1 - 5e-10 39.6 7.0 5e-10 39.6 7.0 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component Pox_A31 PF05771.11 ETO00997.1 - 0.88 9.6 9.2 2.9 7.9 0.2 2.3 2 0 0 2 2 2 0 Poxvirus A31 protein WD40 PF00400.32 ETO00998.1 - 7.4e-11 42.4 5.0 0.00021 22.0 0.0 3.5 4 1 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO00998.1 - 5.6e-05 22.0 0.1 0.016 13.9 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO00998.1 - 0.00044 20.5 0.1 0.38 11.1 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain USP7_C2 PF14533.6 ETO00998.1 - 0.15 11.7 0.0 0.24 11.1 0.0 1.4 1 1 0 1 1 1 0 Ubiquitin-specific protease C-terminal DUF3232 PF11554.8 ETO00999.1 - 0.074 13.4 0.3 1 9.8 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3232) AAA_14 PF13173.6 ETO01000.1 - 1.8e-05 24.8 0.4 0.02 14.9 0.0 3.4 2 1 1 3 3 3 1 AAA domain AAA PF00004.29 ETO01000.1 - 0.00015 22.2 0.0 0.00065 20.1 0.0 2.2 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_8 PF12780.7 ETO01000.1 - 0.00019 20.9 0.0 0.00051 19.4 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 ETO01000.1 - 0.00021 21.3 0.0 0.00062 19.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO01000.1 - 0.00029 21.3 0.6 0.0043 17.6 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ETO01000.1 - 0.00046 20.5 0.2 0.0031 17.8 0.0 2.5 2 1 1 3 3 3 1 AAA domain DUF815 PF05673.13 ETO01000.1 - 0.00089 18.5 0.0 0.0016 17.6 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_7 PF12775.7 ETO01000.1 - 0.0019 17.7 0.3 0.0061 16.1 0.1 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETO01000.1 - 0.0029 17.5 0.0 0.0067 16.4 0.0 1.6 1 0 0 1 1 1 1 RsgA GTPase MCM PF00493.23 ETO01000.1 - 0.0089 15.1 0.1 0.095 11.8 0.0 2.4 2 1 0 2 2 2 1 MCM P-loop domain Sigma54_activat PF00158.26 ETO01000.1 - 0.097 12.4 0.0 0.24 11.1 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ETO01000.1 - 0.16 12.4 0.0 0.71 10.2 0.0 2.0 1 1 1 2 2 2 0 AAA ATPase domain AAA_23 PF13476.6 ETO01000.1 - 0.19 12.2 14.0 1.2 9.6 0.0 3.2 3 0 0 3 3 3 0 AAA domain DUF2963 PF11178.8 ETO01001.1 - 9.7 6.0 7.5 27 4.6 0.3 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2963) AAA_8 PF12780.7 ETO01002.1 - 0.00021 20.7 0.0 0.00044 19.7 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_22 PF13401.6 ETO01002.1 - 0.00046 20.5 0.2 0.0017 18.7 0.0 2.0 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ETO01002.1 - 0.00071 19.6 0.0 0.0016 18.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ETO01002.1 - 0.00073 18.8 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO01002.1 - 0.001 19.6 0.8 0.0027 18.2 0.0 1.9 2 1 0 2 2 2 1 ABC transporter AAA PF00004.29 ETO01002.1 - 0.0017 18.8 0.0 0.0044 17.5 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO01002.1 - 0.0018 17.8 0.1 0.0033 17.0 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETO01002.1 - 0.0019 18.1 0.0 0.0036 17.2 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase MCM PF00493.23 ETO01002.1 - 0.03 13.4 0.0 0.05 12.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Sigma54_activat PF00158.26 ETO01002.1 - 0.076 12.7 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ETO01002.1 - 0.16 12.3 0.0 0.3 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ETO01002.1 - 8.4 6.8 13.2 0.83 10.1 0.1 2.5 2 1 0 2 2 2 0 AAA domain Tubulin_C PF03953.17 ETO01003.1 - 1.9e-05 24.8 0.1 2.3e-05 24.6 0.1 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Pkinase PF00069.25 ETO01004.1 - 1.8e-43 148.8 0.0 2.1e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO01004.1 - 9.2e-23 80.8 0.0 1.1e-22 80.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO01004.1 - 0.0015 17.9 0.0 0.0022 17.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO01004.1 - 0.0057 16.6 0.1 0.039 13.9 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ETO01004.1 - 0.0067 16.0 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ETO01004.1 - 0.013 14.5 0.0 0.017 14.1 0.0 1.3 1 1 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO01004.1 - 0.018 13.8 0.0 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 ETO01004.1 - 0.077 12.3 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Guanylate_cyc PF00211.20 ETO01006.1 - 9.1e-09 35.2 0.4 1.4e-08 34.6 0.4 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF1823 PF08853.11 ETO01006.1 - 0.051 13.8 0.0 0.09 13.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1823) GlcNAc PF11397.8 ETO01007.1 - 6.3e-35 121.3 0.0 6.8e-35 121.2 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) TPR_17 PF13431.6 ETO01008.1 - 5.4e-05 23.3 3.0 0.0009 19.5 0.4 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01008.1 - 0.00014 21.5 0.1 0.00057 19.6 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01008.1 - 0.0021 18.0 0.1 0.0074 16.3 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat FemAB_like PF04339.12 ETO01008.1 - 0.0031 16.7 0.4 0.0043 16.2 0.4 1.1 1 0 0 1 1 1 1 Peptidogalycan biosysnthesis/recognition TPR_8 PF13181.6 ETO01008.1 - 0.0065 16.6 1.2 0.029 14.5 0.0 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01008.1 - 0.017 14.8 1.9 0.047 13.4 0.3 2.1 2 0 0 2 2 2 0 TPR repeat DUF5398 PF17376.2 ETO01009.1 - 0.057 14.0 8.2 0.43 11.2 0.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5398) Bromodomain PF00439.25 ETO01010.1 - 0.022 14.8 0.1 0.045 13.8 0.1 1.5 1 0 0 1 1 1 0 Bromodomain HTH_52 PF18576.1 ETO01011.1 - 0.0028 17.8 1.1 0.071 13.3 0.0 2.4 2 0 0 2 2 2 2 Helix-turn-helix domain VWD PF00094.25 ETO01012.1 - 0.26 11.5 11.2 6.2 7.1 10.7 2.1 1 1 0 1 1 1 0 von Willebrand factor type D domain FlxA PF14282.6 ETO01012.1 - 4.6 7.3 31.4 1.7 8.7 28.8 1.6 1 1 0 1 1 1 0 FlxA-like protein B56 PF01603.20 ETO01013.1 - 1.9e-42 145.7 1.5 2.2e-42 145.5 1.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) B56 PF01603.20 ETO01014.1 - 0.0057 15.7 0.8 0.015 14.3 0.8 1.7 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) B56 PF01603.20 ETO01015.1 - 3.2e-12 46.2 3.8 5e-12 45.5 3.8 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Atrophin-1 PF03154.15 ETO01015.1 - 0.023 13.0 6.5 0.023 13.0 6.5 1.0 1 0 0 1 1 1 0 Atrophin-1 family Trypan_PARP PF05887.11 ETO01015.1 - 0.67 9.9 10.3 1.2 9.1 10.3 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_S64 PF08192.11 ETO01015.1 - 0.71 8.3 15.1 0.81 8.1 15.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 Menin PF05053.13 ETO01015.1 - 0.72 8.1 15.4 0.9 7.8 15.4 1.1 1 0 0 1 1 1 0 Menin LAP1C PF05609.12 ETO01015.1 - 0.98 8.4 17.4 1.1 8.2 17.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 ETO01015.1 - 3.7 7.5 9.3 7.4 6.6 9.3 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region B56 PF01603.20 ETO01016.1 - 7e-47 160.3 5.5 8e-47 160.1 5.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) ECSCR PF15820.5 ETO01017.1 - 0.00027 20.7 0.3 0.0006 19.6 0.3 1.6 1 0 0 1 1 1 1 Endothelial cell-specific chemotaxis regulator MIG-14_Wnt-bd PF06664.12 ETO01017.1 - 0.0032 16.7 2.5 0.17 11.1 1.1 2.1 2 0 0 2 2 2 2 Wnt-binding factor required for Wnt secretion OAD_gamma PF04277.13 ETO01017.1 - 0.0042 17.6 6.1 0.032 14.8 1.7 2.7 2 1 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain Protocadherin PF08374.11 ETO01017.1 - 0.0064 16.5 0.5 0.012 15.6 0.5 1.6 1 0 0 1 1 1 1 Protocadherin EphA2_TM PF14575.6 ETO01017.1 - 0.015 16.2 0.1 0.043 14.7 0.1 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 ETO01017.1 - 0.026 15.5 0.3 0.026 15.5 0.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF2615 PF11027.8 ETO01017.1 - 0.052 13.7 0.5 0.13 12.4 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) MEA1 PF06910.11 ETO01017.1 - 0.94 10.1 7.2 0.071 13.7 1.0 2.0 2 0 0 2 2 2 0 Male enhanced antigen 1 (MEA1) DUF3671 PF12420.8 ETO01017.1 - 1.9 8.6 7.9 1.1 9.3 4.4 2.2 2 0 0 2 2 2 0 Protein of unknown function ASFV_J13L PF05568.11 ETO01017.1 - 1.9 8.2 9.2 3.8 7.2 9.2 1.5 1 1 0 1 1 1 0 African swine fever virus J13L protein Shisa PF13908.6 ETO01017.1 - 2.5 8.3 3.6 3.5 7.8 3.3 1.6 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator Phlebovirus_G2 PF07245.11 ETO01017.1 - 2.7 6.4 4.3 4 5.8 4.3 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G2 Cofac_haem_bdg PF04187.13 ETO01018.1 - 0.022 14.8 0.0 0.062 13.3 0.0 1.8 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Arc_PepC_II PF06847.11 ETO01018.1 - 0.54 10.8 2.7 1.4 9.4 0.1 3.2 3 0 0 3 3 3 0 Archaeal Peptidase A24 C-terminus Type II FAM163 PF15069.6 ETO01018.1 - 0.71 10.3 5.7 0.15 12.5 0.3 2.4 2 0 0 2 2 2 0 FAM163 family Glyco_transf_49 PF13896.6 ETO01019.1 - 6.2e-14 52.1 0.0 1.2e-13 51.1 0.0 1.5 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 ETO01019.1 - 0.001 18.9 0.0 0.0022 17.8 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ETO01019.1 - 0.018 14.5 0.0 0.084 12.3 0.0 2.0 2 0 0 2 2 2 0 Glycosyltransferase like family 2 TUTF7_u4 PF16631.5 ETO01019.1 - 0.06 14.0 1.0 0.15 12.7 1.0 1.6 1 0 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 Ldh_1_N PF00056.23 ETO01020.1 - 0.00017 21.7 0.0 0.00021 21.4 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain Kelch_4 PF13418.6 ETO01021.1 - 0.00066 19.6 0.1 0.0033 17.4 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01021.1 - 0.04 13.5 0.5 0.82 9.3 0.2 2.3 2 0 0 2 2 2 0 Kelch motif SecY PF00344.20 ETO01022.1 - 6.8e-33 114.2 2.8 6.8e-33 114.2 2.8 1.4 2 0 0 2 2 2 1 SecY translocase QCR10 PF09796.9 ETO01022.1 - 0.015 15.4 0.3 0.13 12.3 0.1 2.5 2 0 0 2 2 2 0 Ubiquinol-cytochrome-c reductase complex subunit (QCR10) SieB PF14163.6 ETO01022.1 - 0.022 14.3 0.3 0.093 12.2 0.0 2.1 2 0 0 2 2 2 0 Super-infection exclusion protein B FAA_hydrolase PF01557.18 ETO01024.1 - 2.7e-47 161.2 0.0 4.5e-47 160.5 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Med26 PF08711.11 ETO01026.1 - 0.084 12.9 0.0 0.13 12.3 0.0 1.4 1 0 0 1 1 1 0 TFIIS helical bundle-like domain UN_NPL4 PF11543.8 ETO01026.1 - 0.13 12.7 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Lactamase_B_6 PF16661.5 ETO01027.1 - 0.042 13.3 0.1 0.047 13.1 0.1 1.1 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain Adeno_E3_15_3 PF03307.14 ETO01027.1 - 0.06 13.3 0.2 0.074 13.0 0.2 1.2 1 0 0 1 1 1 0 Adenovirus 15.3kD protein in E3 region Ank_2 PF12796.7 ETO01028.1 - 0.00092 19.8 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) S6PP PF05116.13 ETO01028.1 - 0.047 13.2 0.0 0.073 12.6 0.0 1.5 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase DHC PF09626.10 ETO01028.1 - 0.12 13.3 0.3 0.34 11.8 0.0 1.8 2 0 0 2 2 2 0 Dihaem cytochrome c Tetraspanin PF00335.20 ETO01029.1 - 2.9 7.6 6.3 0.27 10.9 0.5 1.7 1 1 1 2 2 2 0 Tetraspanin family Tubulin_C PF03953.17 ETO01030.1 - 2.2e-26 92.5 0.1 3.9e-26 91.7 0.1 1.3 1 1 0 1 1 1 1 Tubulin C-terminal domain Interferon PF00143.19 ETO01031.1 - 0.14 12.4 4.5 0.51 10.5 0.2 2.2 2 0 0 2 2 2 0 Interferon alpha/beta domain Tubulin_C PF03953.17 ETO01032.1 - 1.8e-23 83.1 0.0 1e-22 80.7 0.0 1.9 1 1 0 1 1 1 1 Tubulin C-terminal domain DS PF01916.17 ETO01032.1 - 0.077 12.2 0.0 0.096 11.9 0.0 1.1 1 0 0 1 1 1 0 Deoxyhypusine synthase LAMTOR5 PF16672.5 ETO01032.1 - 0.13 12.2 0.1 0.23 11.4 0.1 1.3 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Cnd1 PF12717.7 ETO01034.1 - 7.1e-07 29.4 4.6 0.00073 19.6 2.0 2.4 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO01034.1 - 1.5e-06 27.9 0.0 0.00021 21.3 0.0 3.8 5 0 0 5 5 4 1 HEAT repeat HEAT_2 PF13646.6 ETO01034.1 - 2.1e-06 28.1 0.0 0.00025 21.4 0.0 2.3 1 1 2 3 3 3 1 HEAT repeats ENTH PF01417.20 ETO01034.1 - 1.4e-05 25.2 2.2 0.058 13.5 0.1 3.2 1 1 3 4 4 4 2 ENTH domain CLASP_N PF12348.8 ETO01034.1 - 0.00014 21.5 2.9 0.013 15.1 0.5 2.2 1 1 1 2 2 2 2 CLASP N terminal TIP120 PF08623.10 ETO01034.1 - 0.0008 19.2 1.6 0.23 11.2 0.1 2.8 1 1 2 3 3 3 2 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 ETO01034.1 - 0.002 18.6 0.0 0.46 11.1 0.0 3.0 3 1 1 4 4 3 1 HEAT-like repeat Spore_Cse60 PF10957.8 ETO01034.1 - 0.009 16.0 0.6 11 6.1 0.0 3.4 3 0 0 3 3 3 0 Sporulation protein Cse60 RTP1_C1 PF10363.9 ETO01034.1 - 0.018 15.2 0.3 0.42 10.8 0.3 2.8 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 MOR2-PAG1_N PF14222.6 ETO01034.1 - 0.028 13.4 0.0 1.3 7.9 0.0 2.3 1 1 1 2 2 2 0 Cell morphogenesis N-terminal Vac14_Fab1_bd PF12755.7 ETO01034.1 - 0.037 14.6 0.6 0.69 10.5 0.0 2.7 1 1 2 3 3 3 0 Vacuolar 14 Fab1-binding region DUF445 PF04286.12 ETO01034.1 - 0.038 13.8 1.0 0.057 13.2 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Closter_coat PF01785.17 ETO01034.1 - 0.044 13.0 2.1 5.1 6.3 0.1 2.9 2 1 1 3 3 3 0 Closterovirus coat protein Phage_TAC_3 PF06896.11 ETO01034.1 - 0.063 13.9 2.2 2.8 8.6 0.0 3.0 3 1 0 3 3 3 0 Phage tail assembly chaperone proteins, TAC DUF5071 PF16804.5 ETO01034.1 - 0.08 13.2 0.1 0.83 9.9 0.0 2.5 2 2 1 3 3 3 0 Domain of unknown function (DUF5071) Med23 PF11573.8 ETO01034.1 - 0.095 10.3 3.0 0.31 8.6 0.8 2.0 1 1 1 2 2 2 0 Mediator complex subunit 23 Ribosomal_S3Ae PF01015.18 ETO01034.1 - 0.13 11.8 1.3 0.72 9.4 0.6 2.3 1 1 1 2 2 2 0 Ribosomal S3Ae family bVLRF1 PF18826.1 ETO01034.1 - 0.14 12.0 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor MH1 PF03165.16 ETO01034.1 - 0.35 11.1 6.0 4.4 7.6 0.1 3.3 2 1 0 2 2 2 0 MH1 domain DUF3349 PF11829.8 ETO01034.1 - 0.59 11.0 1.8 51 4.7 0.3 3.6 1 1 4 5 5 5 0 Protein of unknown function (DUF3349) WD40 PF00400.32 ETO01035.1 - 3.1e-26 91.1 21.2 1.2e-06 29.1 2.3 6.4 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01035.1 - 2.7e-11 43.6 1.8 0.024 14.9 0.0 4.0 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01035.1 - 4.1e-06 26.3 4.4 0.015 14.6 1.1 4.0 1 1 2 4 4 4 4 WD40-like domain DEP PF00610.21 ETO01036.1 - 1.4e-15 57.1 0.2 1.8e-15 56.7 0.2 1.1 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_1 PF00036.32 ETO01037.1 - 0.0042 16.5 0.0 0.0086 15.6 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ETO01037.1 - 0.005 16.3 0.0 0.0089 15.5 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO01037.1 - 0.028 14.9 0.0 0.05 14.1 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair Mt_ATP-synt_B PF05405.14 ETO01037.1 - 0.032 13.9 0.5 0.048 13.3 0.5 1.3 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) EF-hand_6 PF13405.6 ETO01037.1 - 0.04 13.9 0.0 0.085 12.8 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain Plasmodium_Vir PF05795.11 ETO01037.1 - 0.32 10.4 4.5 0.049 13.0 0.8 1.5 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Tropomyosin_1 PF12718.7 ETO01038.1 - 5e-05 23.5 46.3 0.004 17.3 8.3 3.2 1 1 2 3 3 3 2 Tropomyosin like HOOK PF05622.12 ETO01038.1 - 0.00037 18.8 17.6 0.00037 18.8 17.6 2.4 1 1 1 2 2 2 1 HOOK protein CEP63 PF17045.5 ETO01038.1 - 0.00099 19.1 23.5 0.00099 19.1 23.5 2.1 1 1 1 2 2 2 1 Centrosomal protein of 63 kDa Fib_alpha PF08702.10 ETO01038.1 - 0.0036 17.5 17.6 0.0036 17.5 17.6 3.1 1 1 2 3 3 3 1 Fibrinogen alpha/beta chain family Filament PF00038.21 ETO01038.1 - 0.017 14.8 37.1 0.022 14.3 37.1 1.1 1 0 0 1 1 1 0 Intermediate filament protein GAS PF13851.6 ETO01038.1 - 0.019 14.3 47.1 0.56 9.5 22.2 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ETO01038.1 - 0.022 15.3 45.9 0.73 10.4 20.6 2.5 1 1 1 2 2 2 0 Apg6 coiled-coil region KASH_CCD PF14662.6 ETO01038.1 - 0.063 13.1 46.5 0.061 13.1 21.7 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Seryl_tRNA_N PF02403.22 ETO01038.1 - 0.14 12.4 44.8 0.075 13.3 15.8 3.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain MAD PF05557.13 ETO01038.1 - 0.3 9.4 45.0 0.49 8.7 45.0 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein SPATA1_C PF15743.5 ETO01038.1 - 0.7 10.0 44.7 0.31 11.1 25.9 2.4 1 1 1 2 2 2 0 Spermatogenesis-associated C-terminus Jnk-SapK_ap_N PF09744.9 ETO01038.1 - 0.75 10.0 40.6 3.3 7.9 22.4 2.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 ATG16 PF08614.11 ETO01038.1 - 0.76 10.0 38.2 1.2 9.4 11.8 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF948 PF06103.11 ETO01038.1 - 0.87 9.9 16.5 0.34 11.2 1.4 3.7 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) HAP1_N PF04849.13 ETO01038.1 - 1.5 8.0 38.8 6.1 6.0 14.1 3.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Fmp27_WPPW PF10359.9 ETO01038.1 - 1.6 7.5 38.1 0.24 10.2 18.5 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain WDCP PF15390.6 ETO01038.1 - 1.7 7.0 21.6 2.1 6.6 21.6 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family TMF_TATA_bd PF12325.8 ETO01038.1 - 1.8 8.8 37.5 2.4 8.4 7.2 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Rootletin PF15035.6 ETO01038.1 - 2 8.4 36.9 3.5 7.6 31.8 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion CENP-F_leu_zip PF10473.9 ETO01038.1 - 2.3 8.2 41.4 2.7 8.0 17.4 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO01038.1 - 2.7 6.8 44.2 6.7 5.5 17.9 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-Q PF13094.6 ETO01038.1 - 2.7 8.2 29.2 0.4 10.9 12.7 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Phage_GPO PF05929.11 ETO01038.1 - 2.9 7.4 27.7 2.3 7.7 13.5 2.1 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase AAA_13 PF13166.6 ETO01038.1 - 3.1 6.3 42.7 1.1 7.8 14.9 2.4 1 1 0 1 1 1 0 AAA domain DUF3450 PF11932.8 ETO01038.1 - 3.2 7.0 39.6 0.2 10.9 13.9 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Pox_A_type_inc PF04508.12 ETO01038.1 - 3.9 7.5 10.2 5.7 7.0 0.6 4.1 5 0 0 5 5 3 0 Viral A-type inclusion protein repeat HemX PF04375.14 ETO01038.1 - 6.4 6.0 36.3 5.8 6.1 15.6 2.9 1 1 2 3 3 3 0 HemX, putative uroporphyrinogen-III C-methyltransferase SlyX PF04102.12 ETO01038.1 - 7.1 7.3 28.0 22 5.8 4.7 4.9 2 2 2 4 4 4 0 SlyX PI3K_P85_iSH2 PF16454.5 ETO01038.1 - 7.2 6.2 41.3 0.48 10.0 12.5 3.0 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Uso1_p115_C PF04871.13 ETO01038.1 - 7.3 7.0 43.0 3 8.2 8.9 3.1 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region S10_plectin PF03501.15 ETO01039.1 - 0.14 12.3 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Plectin/S10 domain Tubulin PF00091.25 ETO01040.1 - 1.5e-09 38.4 0.0 1.8e-09 38.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain TPR_12 PF13424.6 ETO01041.1 - 6.2e-96 314.8 20.8 3.1e-22 78.6 0.7 4.6 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01041.1 - 9.1e-74 241.6 5.0 2.6e-11 43.0 0.0 7.0 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01041.1 - 3.1e-61 200.9 47.6 1.2e-10 40.7 0.6 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01041.1 - 4.6e-60 195.3 15.8 4.1e-09 35.8 0.0 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01041.1 - 3.3e-52 170.4 51.5 4.2e-09 35.9 1.6 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01041.1 - 8.4e-52 169.2 35.2 2.3e-08 33.5 0.1 7.2 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01041.1 - 6.4e-26 90.7 0.1 8.5e-07 29.5 0.0 5.6 4 1 2 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01041.1 - 8e-23 79.2 0.0 0.047 14.5 0.0 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01041.1 - 2.3e-22 77.7 22.3 6.9e-05 23.0 0.0 7.9 8 3 0 8 8 6 6 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01041.1 - 2.5e-22 77.9 10.6 0.0026 18.3 0.1 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01041.1 - 5.9e-18 64.3 58.7 0.00023 20.8 1.6 10.7 7 4 4 11 11 11 7 TPR repeat TPR_3 PF07720.12 ETO01041.1 - 1.6e-17 63.1 28.3 0.007 16.3 0.1 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO01041.1 - 6.7e-11 42.1 0.0 0.0044 16.4 0.0 3.0 1 1 2 3 3 3 3 MalT-like TPR region MIT PF04212.18 ETO01041.1 - 1.5e-10 41.0 34.7 0.13 12.4 0.6 7.1 7 0 0 7 7 7 5 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO01041.1 - 2.6e-10 39.8 18.8 0.15 12.3 0.2 6.5 7 0 0 7 7 6 3 PPR repeat DUF5113 PF17140.4 ETO01041.1 - 2.4e-09 37.2 23.0 0.046 13.5 0.1 6.1 5 1 1 6 6 6 4 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 ETO01041.1 - 2.8e-09 36.3 9.0 3.6 7.1 0.0 7.2 7 0 0 7 7 7 2 SHNi-TPR TPR_19 PF14559.6 ETO01041.1 - 4.1e-09 36.8 6.3 0.018 15.6 0.3 4.8 2 2 4 6 6 6 4 Tetratricopeptide repeat DUF4810 PF16068.5 ETO01041.1 - 2.7e-08 34.3 9.0 0.82 10.3 0.0 5.6 5 1 0 5 5 5 2 Domain of unknown function (DUF4810) TPR_9 PF13371.6 ETO01041.1 - 1.4e-07 31.5 0.0 0.32 11.2 0.0 4.9 2 2 3 5 5 4 2 Tetratricopeptide repeat Sel1 PF08238.12 ETO01041.1 - 1.8e-07 31.6 27.6 6.4 7.6 0.3 9.0 7 4 0 7 7 7 0 Sel1 repeat Mob_Pre PF01076.19 ETO01041.1 - 3.6e-07 30.2 16.1 1.1e-05 25.4 2.3 3.9 1 1 3 4 4 4 2 Plasmid recombination enzyme ANAPC3 PF12895.7 ETO01041.1 - 9.9e-07 28.9 23.3 0.012 15.9 2.3 5.4 1 1 5 6 6 6 6 Anaphase-promoting complex, cyclosome, subunit 3 ATP-synt_E_2 PF08112.11 ETO01041.1 - 3.2e-06 27.3 26.3 3.1 8.2 0.5 7.2 7 0 0 7 7 7 1 ATP synthase epsilon subunit RPN7 PF10602.9 ETO01041.1 - 3.3e-06 26.9 21.4 0.015 15.0 3.4 4.7 1 1 4 5 5 5 4 26S proteasome subunit RPN7 DUF2225 PF09986.9 ETO01041.1 - 8.4e-06 25.7 18.7 0.16 11.7 5.6 4.0 1 1 3 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2225) SPO22 PF08631.10 ETO01041.1 - 0.00052 19.6 17.8 0.07 12.6 0.1 5.1 2 1 2 5 5 5 1 Meiosis protein SPO22/ZIP4 like DUF5475 PF17569.2 ETO01041.1 - 0.023 15.0 0.1 5.8 7.3 0.0 3.9 5 1 0 5 5 4 0 Family of unknown function (DUF5475) DUF3856 PF12968.7 ETO01041.1 - 0.039 14.0 6.3 1.6 8.8 0.2 3.7 1 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) Fis1_TPR_C PF14853.6 ETO01041.1 - 0.063 13.4 0.9 0.063 13.4 0.9 6.3 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat Clathrin PF00637.20 ETO01041.1 - 0.18 11.6 18.0 52 3.7 0.1 5.9 2 1 1 4 4 4 0 Region in Clathrin and VPS Tat PF00539.18 ETO01041.1 - 0.2 11.8 0.1 95 3.3 0.0 4.4 4 2 0 6 6 4 0 Transactivating regulatory protein (Tat) SPAN-X PF07458.12 ETO01041.1 - 0.22 12.0 12.7 29 5.2 0.1 6.0 3 3 3 7 7 7 0 Sperm protein associated with nucleus, mapped to X chromosome TetR_C_19 PF17924.1 ETO01041.1 - 0.38 11.4 12.5 50 4.5 0.1 5.2 5 2 0 6 6 5 0 Tetracyclin repressor-like, C-terminal domain RSS_P20 PF11757.8 ETO01041.1 - 0.56 10.7 14.1 26 5.3 0.1 5.4 4 1 1 5 5 5 0 Suppressor of RNA silencing P21-like N-terminal domain HTH_Bact PF18768.1 ETO01041.1 - 0.59 9.7 21.5 5.8 6.6 0.1 7.6 7 2 2 9 9 9 0 Helix-turn-helix bacterial domain YecM PF06185.12 ETO01041.1 - 0.72 9.5 10.8 4.2 7.0 0.0 5.1 4 2 3 7 7 6 0 YecM protein OEP PF02321.18 ETO01041.1 - 3.6 7.4 9.8 8.5 6.1 0.4 3.6 2 2 2 4 4 4 0 Outer membrane efflux protein NHL PF01436.21 ETO01041.1 - 4.9 7.4 8.3 0.68 10.1 0.2 3.4 4 0 0 4 4 3 0 NHL repeat KH_8 PF17903.1 ETO01045.1 - 0.075 13.1 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Krr1 KH1 domain DUF1800 PF08811.11 ETO01045.1 - 0.096 11.7 0.1 0.12 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1800) Dynein_heavy PF03028.15 ETO01046.1 - 0.68 10.0 6.4 0.57 10.3 2.7 2.2 1 1 1 2 2 2 0 Dynein heavy chain region D6 P-loop domain Microtub_bd PF16796.5 ETO01049.1 - 6.4e-23 81.3 3.3 8.4e-23 81.0 3.3 1.2 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 ETO01049.1 - 1.8e-11 43.6 0.7 2.7e-11 43.0 0.7 1.2 1 0 0 1 1 1 1 Kinesin motor domain zf-TRAF PF02176.18 ETO01050.1 - 4.3e-06 27.3 0.8 4.3e-06 27.3 0.8 3.2 3 1 2 5 5 5 1 TRAF-type zinc finger Kelch_1 PF01344.25 ETO01052.1 - 6e-05 22.6 0.5 0.00036 20.0 0.0 2.5 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO01052.1 - 0.0029 17.5 0.6 0.034 14.1 0.2 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO01052.1 - 0.0051 17.1 2.9 3.4 8.1 0.3 3.3 2 1 2 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO01052.1 - 0.011 15.7 1.7 0.06 13.4 0.2 2.6 2 1 1 3 3 3 0 Galactose oxidase, central domain Glyoxal_oxid_N PF07250.11 ETO01052.1 - 0.076 12.2 0.0 0.14 11.3 0.0 1.4 2 0 0 2 2 2 0 Glyoxal oxidase N-terminus Kelch_3 PF13415.6 ETO01052.1 - 0.086 13.2 0.4 0.86 10.0 0.0 2.6 2 1 1 3 3 3 0 Galactose oxidase, central domain MULE PF10551.9 ETO01053.1 - 0.013 15.9 1.1 1.2 9.6 0.2 2.5 2 0 0 2 2 2 0 MULE transposase domain Ribosomal_L22 PF00237.19 ETO01054.1 - 0.047 13.9 0.1 0.16 12.2 0.1 1.9 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e Kelch_2 PF07646.15 ETO01055.1 - 1.5e-05 24.8 0.1 0.0021 18.0 0.2 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO01055.1 - 5.6e-05 22.6 0.9 0.00011 21.7 0.9 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO01055.1 - 0.00095 19.1 0.1 0.0022 18.0 0.1 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO01055.1 - 0.012 15.9 0.2 0.36 11.2 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO01055.1 - 0.039 14.0 0.3 7.4 6.7 0.7 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO01055.1 - 0.14 12.5 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Apt1 PF10351.9 ETO01057.1 - 0.7 8.7 7.8 1 8.1 7.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4173 PF13777.6 ETO01058.1 - 0.046 13.1 6.7 0.8 9.1 0.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4173) NuA4 PF09340.10 ETO01059.1 - 0.023 14.6 0.3 6.7 6.7 0.1 3.1 2 1 0 2 2 2 0 Histone acetyltransferase subunit NuA4 RE_MamI PF09567.10 ETO01060.1 - 0.078 12.6 7.1 0.015 14.9 2.9 1.9 1 1 1 2 2 2 0 MamI restriction endonuclease BLOC1_2 PF10046.9 ETO01060.1 - 0.14 12.5 0.3 0.14 12.5 0.3 2.9 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DASH_Dam1 PF08653.10 ETO01060.1 - 0.22 11.4 0.1 0.22 11.4 0.1 2.9 4 0 0 4 4 4 0 DASH complex subunit Dam1 DivIC PF04977.15 ETO01060.1 - 1.2 9.0 7.8 1.2 9.0 1.9 3.0 2 0 0 2 2 2 0 Septum formation initiator MIEAP PF16026.5 ETO01063.1 - 8.6e-07 29.4 3.8 1.3e-05 25.5 3.8 2.3 1 1 0 1 1 1 1 Mitochondria-eating protein Memo PF01875.17 ETO01064.1 - 8.6e-65 218.6 0.2 9.6e-65 218.4 0.2 1.0 1 0 0 1 1 1 1 Memo-like protein Asp_Arg_Hydrox PF05118.15 ETO01066.1 - 6.1e-07 29.4 0.4 2.6e-06 27.4 0.1 2.0 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase FAM176 PF14851.6 ETO01066.1 - 0.016 14.8 0.6 0.02 14.6 0.6 1.1 1 0 0 1 1 1 0 FAM176 family DUF4533 PF15047.6 ETO01066.1 - 0.049 13.2 0.6 0.061 12.9 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) PBP_sp32 PF07222.12 ETO01066.1 - 0.065 12.7 1.2 0.078 12.4 1.2 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 RasGAP PF00616.19 ETO01066.1 - 0.13 11.9 2.0 0.18 11.5 2.0 1.1 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase TatD_DNase PF01026.21 ETO01067.1 - 4.1e-11 42.7 0.0 4.5e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 TatD related DNase CDC45 PF02724.14 ETO01067.1 - 0.0015 17.0 21.3 0.0015 17.0 21.3 1.7 2 0 0 2 2 2 1 CDC45-like protein SAPS PF04499.15 ETO01067.1 - 0.062 12.1 16.9 0.083 11.7 16.9 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PAC1 PF16094.5 ETO01067.1 - 0.062 12.5 0.2 0.062 12.5 0.2 2.9 2 1 0 2 2 2 0 Proteasome assembly chaperone 4 Zip PF02535.22 ETO01067.1 - 0.062 12.5 11.9 0.092 11.9 11.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 ETO01067.1 - 0.85 8.3 13.2 1.3 7.7 13.2 1.3 1 0 0 1 1 1 0 Raftlin DUF2201_N PF13203.6 ETO01067.1 - 0.9 9.1 7.3 0.45 10.1 5.7 1.3 1 1 0 1 1 1 0 Putative metallopeptidase domain FTA4 PF13093.6 ETO01069.1 - 0.0029 17.6 1.7 0.0029 17.6 1.7 2.0 1 1 0 2 2 2 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 T3SS_basalb_I PF17001.5 ETO01069.1 - 0.029 15.0 6.3 0.13 12.8 0.1 3.0 2 1 1 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI DUF3683 PF12447.8 ETO01069.1 - 0.32 11.1 5.1 7.2 6.8 0.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3683) HSBP1 PF06825.12 ETO01069.1 - 0.36 10.7 6.0 0.11 12.3 0.7 3.0 3 0 0 3 3 3 0 Heat shock factor binding protein 1 COG5 PF10392.9 ETO01069.1 - 0.73 10.0 6.2 0.37 11.0 0.8 2.8 2 1 0 2 2 2 0 Golgi transport complex subunit 5 SKA2 PF16740.5 ETO01069.1 - 1.5 8.7 8.9 0.15 11.9 1.2 2.9 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 Aida_N PF08910.10 ETO01069.1 - 2 8.9 7.8 0.42 11.0 0.8 3.0 1 1 1 3 3 3 0 Aida N-terminus Pup PF05639.11 ETO01069.1 - 3 8.8 8.0 5.3 8.0 0.2 3.5 3 0 0 3 3 3 0 Pup-like protein Noelin-1 PF12308.8 ETO01069.1 - 5.5 7.0 9.9 2.7 8.0 0.5 3.5 2 2 0 4 4 4 0 Neurogenesis glycoprotein CLZ PF16526.5 ETO01069.1 - 5.6 7.4 11.6 0.64 10.4 0.7 3.8 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels GCHY-1 PF02649.14 ETO01070.1 - 0.058 12.9 1.2 0.096 12.2 1.2 1.4 1 0 0 1 1 1 0 Type I GTP cyclohydrolase folE2 TPR_12 PF13424.6 ETO01072.1 - 2.4e-112 367.4 12.3 2.3e-22 79.0 0.2 6.9 1 1 7 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01072.1 - 7.3e-69 226.0 0.1 1.7e-09 37.2 0.0 9.2 9 1 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01072.1 - 9.7e-64 206.8 4.4 7.3e-09 35.1 0.0 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01072.1 - 3.8e-56 184.7 42.5 2.4e-09 36.6 0.5 8.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01072.1 - 2.8e-40 133.2 45.2 1.9e-07 30.8 1.2 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01072.1 - 1.1e-38 128.2 24.1 1.1e-06 28.3 0.2 7.6 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01072.1 - 2.2e-21 74.7 14.8 0.018 15.4 0.0 9.8 6 4 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01072.1 - 1.3e-17 64.2 0.0 0.0021 18.7 0.0 6.9 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01072.1 - 6.8e-16 57.6 0.0 0.58 11.1 0.0 7.0 5 2 2 7 7 7 3 Tetratricopeptide repeat MIT PF04212.18 ETO01072.1 - 4.2e-11 42.7 29.6 0.0045 17.0 0.5 7.0 5 1 2 7 7 7 5 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETO01072.1 - 3.1e-10 40.0 6.2 0.00048 19.6 1.0 4.2 1 1 3 4 4 4 3 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO01072.1 - 1.3e-09 38.1 18.3 0.18 11.6 0.1 6.9 4 3 3 7 7 7 3 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO01072.1 - 3.2e-09 37.2 0.1 0.25 11.9 0.1 5.0 1 1 5 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01072.1 - 4.4e-09 36.4 4.5 0.38 11.5 0.0 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat PPR PF01535.20 ETO01072.1 - 2.3e-08 33.7 19.6 0.87 10.0 0.1 7.0 7 1 0 7 7 7 3 PPR repeat TPR_MalT PF17874.1 ETO01072.1 - 1.1e-07 31.6 0.0 1.7e-06 27.7 0.0 2.0 1 1 0 2 2 2 1 MalT-like TPR region DUF4810 PF16068.5 ETO01072.1 - 5.2e-07 30.1 9.6 2.5 8.7 0.2 6.2 3 3 2 5 5 5 2 Domain of unknown function (DUF4810) TPR_11 PF13414.6 ETO01072.1 - 4.9e-06 26.1 53.9 0.016 14.9 0.9 12.1 8 5 5 13 13 12 4 TPR repeat ANAPC3 PF12895.7 ETO01072.1 - 6.6e-06 26.3 9.8 0.14 12.4 0.2 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO01072.1 - 0.0011 18.9 26.8 0.57 10.2 0.4 7.2 7 0 0 7 7 7 1 Tetratricopeptide repeat ChuX_HutX PF06228.13 ETO01072.1 - 0.0014 18.4 0.0 0.96 9.2 0.0 3.2 3 0 0 3 3 3 1 Haem utilisation ChuX/HutX HemS PF05171.12 ETO01072.1 - 0.0052 16.7 0.0 3 7.8 0.0 3.2 3 0 0 3 3 3 1 Haemin-degrading HemS.ChuX domain RPN7 PF10602.9 ETO01072.1 - 0.0054 16.4 10.5 0.82 9.3 1.4 4.8 2 2 1 4 4 4 1 26S proteasome subunit RPN7 TPR_9 PF13371.6 ETO01072.1 - 0.0074 16.4 0.0 9.4 6.5 0.0 3.4 2 1 0 3 3 3 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO01072.1 - 0.019 14.5 17.0 3.3 7.4 0.0 7.7 8 1 1 9 9 9 0 Helix-turn-helix bacterial domain KH_4 PF13083.6 ETO01072.1 - 0.024 14.5 0.0 4.3 7.3 0.0 2.9 2 1 1 3 3 2 0 KH domain DUF627 PF04781.12 ETO01072.1 - 0.027 14.5 11.0 15 5.6 0.1 5.6 3 3 4 7 7 7 0 Protein of unknown function (DUF627) FlaE PF07559.14 ETO01072.1 - 0.068 13.8 0.6 1.8 9.1 0.1 2.5 2 0 0 2 2 2 0 Flagellar basal body protein FlaE UPF0223 PF05256.12 ETO01072.1 - 0.077 13.3 4.7 0.87 10.0 0.3 3.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0223) NdhO PF11910.8 ETO01072.1 - 0.16 12.2 8.9 5.7 7.2 0.8 4.3 3 1 2 5 5 4 0 Cyanobacterial and plant NDH-1 subunit O Musclin PF11037.8 ETO01072.1 - 0.16 11.9 0.0 27 4.7 0.0 3.7 4 0 0 4 4 4 0 Insulin-resistance promoting peptide in skeletal muscle TPR_5 PF12688.7 ETO01072.1 - 0.18 12.1 0.0 13 6.1 0.0 3.3 2 2 2 4 4 4 0 Tetratrico peptide repeat SHNi-TPR PF10516.9 ETO01072.1 - 0.62 9.6 9.5 32 4.1 0.1 5.6 7 0 0 7 7 6 0 SHNi-TPR Clathrin PF00637.20 ETO01072.1 - 0.75 9.7 15.2 62 3.4 0.3 5.6 2 2 1 4 4 4 0 Region in Clathrin and VPS SPAN-X PF07458.12 ETO01072.1 - 0.93 10.0 3.8 30 5.1 0.1 3.4 4 1 0 4 4 2 0 Sperm protein associated with nucleus, mapped to X chromosome BAR_3 PF16746.5 ETO01072.1 - 1.2 8.8 12.1 33 4.1 0.1 5.4 4 2 1 6 6 6 0 BAR domain of APPL family YtzH PF14165.6 ETO01072.1 - 1.4 9.4 4.2 18 5.8 0.2 3.9 4 0 0 4 4 4 0 YtzH-like protein PAZ PF02170.22 ETO01072.1 - 1.6 8.5 4.9 15 5.4 0.1 2.9 2 1 0 3 3 3 0 PAZ domain Sel1 PF08238.12 ETO01072.1 - 2 9.2 12.8 12 6.7 0.1 6.0 7 0 0 7 7 4 0 Sel1 repeat Mob_Pre PF01076.19 ETO01072.1 - 4.4 7.1 7.9 15 5.3 0.2 3.8 2 1 3 5 5 5 0 Plasmid recombination enzyme TetR_C_19 PF17924.1 ETO01072.1 - 4.9 7.8 8.5 82 3.8 0.1 4.8 6 0 0 6 6 5 0 Tetracyclin repressor-like, C-terminal domain ABC_tran PF00005.27 ETO01073.1 - 7.2e-14 52.5 0.0 1.3e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter ABC_ATPase PF09818.9 ETO01073.1 - 9.2e-06 24.7 0.0 1.1e-05 24.4 0.0 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class SMC_N PF02463.19 ETO01073.1 - 5.8e-05 22.6 0.0 6.6e-05 22.5 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO01073.1 - 0.0022 18.2 0.7 0.057 13.6 0.7 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA PF00004.29 ETO01073.1 - 0.0096 16.3 0.0 0.013 15.9 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) WD40 PF00400.32 ETO01074.1 - 6.7e-41 137.5 22.6 9.2e-08 32.6 0.7 8.0 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01074.1 - 5.2e-16 58.7 1.1 0.0044 17.3 0.0 5.6 4 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01074.1 - 3.8e-09 35.7 6.0 0.17 10.5 0.0 5.6 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO01074.1 - 5e-07 29.3 9.5 0.097 12.0 0.1 4.6 2 2 2 5 5 5 3 WD40-like domain SAM_1 PF00536.30 ETO01075.1 - 3.1e-19 69.2 0.3 5.9e-09 36.3 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO01075.1 - 4.1e-16 58.9 0.3 6.6e-07 29.3 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO01075.1 - 0.00064 19.6 0.2 0.005 16.8 0.0 2.3 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain BSP_II PF05432.11 ETO01075.1 - 0.0024 17.6 19.2 0.18 11.5 0.1 2.6 2 0 0 2 2 2 2 Bone sialoprotein II (BSP-II) Vpu PF00558.19 ETO01075.1 - 3.7 7.4 7.8 0.66 9.8 3.0 2.3 2 0 0 2 2 2 0 Vpu protein PTPRCAP PF15713.5 ETO01075.1 - 7.6 6.8 21.6 7.3 6.9 2.1 2.8 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Gemini_mov PF01708.16 ETO01076.1 - 0.092 12.5 0.1 0.092 12.5 0.1 1.8 2 0 0 2 2 2 0 Geminivirus putative movement protein RNA_lig_T4_1 PF09511.10 ETO01077.1 - 0.054 13.3 0.0 0.06 13.2 0.0 1.1 1 0 0 1 1 1 0 RNA ligase Baculo_LEF-11 PF06385.12 ETO01078.1 - 0.045 14.2 1.1 0.059 13.9 1.1 1.2 1 0 0 1 1 1 0 Baculovirus LEF-11 protein WD40 PF00400.32 ETO01081.1 - 1.8e-53 177.3 15.0 2.1e-11 44.2 0.5 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01081.1 - 2.5e-18 66.1 0.5 0.0023 18.2 0.0 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01081.1 - 1.2e-10 41.3 0.0 9.6e-06 25.1 0.0 3.1 2 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO01081.1 - 9.7e-10 37.9 0.7 0.1 11.5 0.0 4.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO01081.1 - 1.9e-09 36.7 0.4 0.53 8.9 0.0 4.1 3 1 1 4 4 4 4 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO01081.1 - 0.00022 21.3 2.6 4 7.6 0.0 3.9 2 2 2 4 4 4 1 Family of unknown function (DUF5570) Gmad1 PF10647.9 ETO01081.1 - 0.00036 20.4 0.5 0.33 10.6 0.0 3.1 2 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 ETO01081.1 - 0.0005 19.9 3.6 30 4.7 0.0 5.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO01081.1 - 0.00076 18.1 0.5 0.048 12.2 0.1 2.2 1 1 0 2 2 2 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO01081.1 - 0.0011 17.9 1.8 0.056 12.2 0.1 3.1 1 1 2 3 3 3 1 Nup133 N terminal like HPS6 PF15702.5 ETO01081.1 - 0.0049 14.9 0.0 1.1 7.2 0.0 2.9 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 6 protein PALB2_WD40 PF16756.5 ETO01081.1 - 0.027 13.4 1.6 2.9 6.7 0.0 3.2 2 2 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain BBS2_Mid PF14783.6 ETO01081.1 - 0.27 11.3 2.5 16 5.6 0.4 3.9 2 2 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Proteasome_A_N PF10584.9 ETO01081.1 - 3.3 7.5 4.9 42 4.0 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature HMG-CoA_red PF00368.18 ETO01082.1 - 4.7e-100 335.2 0.1 6.2e-100 334.8 0.1 1.1 1 0 0 1 1 1 1 Hydroxymethylglutaryl-coenzyme A reductase ATG11 PF10377.9 ETO01083.1 - 1.8 8.6 7.7 3.2 7.8 7.7 1.4 1 0 0 1 1 1 0 Autophagy-related protein 11 YMF19 PF02326.15 ETO01083.1 - 3.9 8.3 8.9 17 6.3 5.0 2.2 2 0 0 2 2 2 0 Plant ATP synthase F0 WD40 PF00400.32 ETO01084.1 - 2.2e-22 78.9 14.7 4.7e-08 33.6 0.1 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO01084.1 - 5.4e-06 25.3 1.2 0.04 12.6 0.2 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01084.1 - 2.9e-05 24.3 0.1 0.49 10.7 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01084.1 - 0.00082 18.8 1.7 0.016 14.5 0.6 2.3 1 1 2 3 3 3 1 WD40-like domain HEAT PF02985.22 ETO01085.1 - 2e-22 77.3 16.7 0.004 17.3 0.1 11.8 13 1 0 13 13 13 6 HEAT repeat HEAT_2 PF13646.6 ETO01085.1 - 4.3e-19 68.7 1.5 0.17 12.3 0.0 8.0 5 3 2 7 7 7 5 HEAT repeats Cnd1 PF12717.7 ETO01085.1 - 3.4e-12 46.7 8.5 0.02 14.9 0.1 5.6 4 1 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO01085.1 - 1.5e-07 31.9 8.4 1.2 9.8 0.2 6.6 4 3 2 6 6 6 2 Vacuolar 14 Fab1-binding region Cnd3 PF12719.7 ETO01085.1 - 0.0001 21.6 1.5 0.0021 17.3 0.4 2.7 1 1 1 2 2 2 1 Nuclear condensing complex subunits, C-term domain HEAT_EZ PF13513.6 ETO01085.1 - 0.00073 20.0 5.8 5 7.7 0.0 6.9 7 2 2 9 9 9 2 HEAT-like repeat Cohesin_HEAT PF12765.7 ETO01085.1 - 0.0051 17.1 0.5 4.4 7.7 0.1 3.6 3 0 0 3 3 3 1 HEAT repeat associated with sister chromatid cohesion RasGEF_N_2 PF14663.6 ETO01085.1 - 0.074 13.5 2.0 12 6.4 0.0 4.0 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain PB1 PF00564.24 ETO01086.1 - 0.0062 16.4 0.2 0.0086 16.0 0.2 1.2 1 0 0 1 1 1 1 PB1 domain DUF3164 PF11363.8 ETO01086.1 - 0.033 13.8 0.0 0.048 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) GCP_N_terminal PF17681.1 ETO01088.1 - 2e-11 44.1 0.1 3e-11 43.5 0.1 1.3 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal Aldedh PF00171.22 ETO01089.1 - 6.9e-15 54.5 0.0 7.5e-15 54.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Cellulase PF00150.18 ETO01089.1 - 0.0057 16.1 0.0 0.0057 16.1 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Zeta_toxin PF06414.12 ETO01089.1 - 0.11 11.8 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Zeta toxin Leg1 PF05612.12 ETO01090.1 - 0.08 12.1 0.1 0.1 11.8 0.1 1.1 1 0 0 1 1 1 0 Leg1 HSP70 PF00012.20 ETO01091.1 - 6.6e-109 364.8 0.3 2.8e-108 362.7 0.3 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO01091.1 - 3.4e-16 59.0 0.0 4.4e-16 58.6 0.0 1.0 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 ETO01091.1 - 0.00048 19.5 0.1 0.00092 18.5 0.1 1.4 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase HEPPP_synt_1 PF07307.11 ETO01091.1 - 0.021 14.4 0.1 0.035 13.7 0.1 1.2 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 PilM_2 PF11104.8 ETO01091.1 - 0.048 12.7 0.0 1.5 7.8 0.0 2.1 2 0 0 2 2 2 0 Type IV pilus assembly protein PilM; Enterotoxin_ST PF02048.16 ETO01091.1 - 0.31 11.5 3.4 0.48 10.9 0.3 2.3 2 0 0 2 2 2 0 Heat-stable enterotoxin ST EST1_DNA_bind PF10373.9 ETO01093.1 - 4.5e-07 29.6 0.1 4.5e-07 29.6 0.1 2.2 3 0 0 3 3 3 1 Est1 DNA/RNA binding domain EST1 PF10374.9 ETO01093.1 - 7.2e-06 26.7 2.0 7.2e-06 26.7 2.0 1.7 2 0 0 2 2 2 1 Telomerase activating protein Est1 TPR_17 PF13431.6 ETO01093.1 - 0.0023 18.2 0.0 0.009 16.3 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat DUF3106 PF11304.8 ETO01093.1 - 0.02 15.4 1.1 0.02 15.4 1.1 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3106) TPR_2 PF07719.17 ETO01093.1 - 0.038 14.1 0.0 1.6 9.0 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01093.1 - 0.042 13.5 0.1 0.21 11.3 0.0 2.2 2 0 0 2 2 2 0 TPR repeat Chalcone PF02431.15 ETO01093.1 - 0.065 12.6 0.3 0.15 11.5 0.0 1.7 2 0 0 2 2 2 0 Chalcone-flavanone isomerase KilA-N PF04383.13 ETO01093.1 - 0.18 11.7 0.2 0.18 11.7 0.2 2.1 2 1 0 2 2 2 0 KilA-N domain DUF3450 PF11932.8 ETO01093.1 - 1.4 8.2 12.3 0.24 10.7 0.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Nup160 PF11715.8 ETO01094.1 - 0.00022 20.0 0.3 0.00026 19.8 0.3 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 WD40 PF00400.32 ETO01094.1 - 0.0064 17.3 2.2 0.0064 17.3 2.2 3.1 3 1 0 3 3 3 1 WD domain, G-beta repeat PUB PF09409.10 ETO01095.1 - 0.013 15.4 0.7 0.051 13.5 0.7 2.0 1 0 0 1 1 1 0 PUB domain NACHT PF05729.12 ETO01096.1 - 0.00088 19.2 0.0 0.0019 18.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO01096.1 - 0.0068 16.9 0.1 0.098 13.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ETO01096.1 - 0.0068 16.4 0.0 0.023 14.7 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 ETO01096.1 - 0.013 15.8 0.0 0.03 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO01096.1 - 0.04 14.3 0.3 0.18 12.2 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_16 PF13191.6 ETO01096.1 - 0.05 14.0 0.0 0.13 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO01096.1 - 0.058 13.9 0.0 0.19 12.3 0.0 1.8 2 1 0 2 2 2 0 ABC transporter Torsin PF06309.11 ETO01096.1 - 0.074 13.2 0.0 0.13 12.4 0.0 1.4 1 0 0 1 1 1 0 Torsin PRK PF00485.18 ETO01096.1 - 0.086 12.6 0.1 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_30 PF13604.6 ETO01096.1 - 0.088 12.5 0.0 0.16 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO01096.1 - 0.095 12.7 0.0 1 9.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ETO01096.1 - 0.21 11.3 0.0 0.37 10.6 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain TFR_dimer PF04253.15 ETO01098.1 - 0.045 13.8 0.1 0.15 12.2 0.0 1.9 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain DUF4710 PF15828.5 ETO01099.1 - 0.56 10.4 7.9 0.22 11.7 5.1 1.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4710) RCC1_2 PF13540.6 ETO01101.1 - 4.9e-12 45.3 7.7 6e-05 22.7 0.2 3.3 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO01101.1 - 8.6e-07 29.5 0.9 1.2 9.8 0.0 4.2 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat Mucin PF01456.17 ETO01101.1 - 0.021 14.8 39.5 0.037 14.0 39.5 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Reprolysin_3 PF13582.6 ETO01101.1 - 0.13 12.7 2.8 0.28 11.7 2.0 2.0 2 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like Sporozoite_P67 PF05642.11 ETO01101.1 - 0.31 9.1 9.3 0.48 8.5 9.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen MGC-24 PF05283.11 ETO01101.1 - 0.43 11.0 21.4 0.78 10.2 21.4 1.4 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin FSA_C PF10479.9 ETO01101.1 - 0.92 7.6 14.9 1.4 7.0 14.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Phage_holin_3_6 PF07332.11 ETO01102.1 - 0.34 11.0 2.1 0.4 10.7 2.1 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Peptidase_C65 PF10275.9 ETO01103.1 - 0.00014 21.4 0.2 0.00015 21.3 0.2 1.1 1 0 0 1 1 1 1 Peptidase C65 Otubain KELK PF15796.5 ETO01103.1 - 0.02 15.3 0.3 0.034 14.6 0.0 1.5 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase MCM_N PF14551.6 ETO01103.1 - 0.075 13.6 0.7 0.088 13.4 0.7 1.1 1 0 0 1 1 1 0 MCM N-terminal domain Topoisom_I_N PF02919.15 ETO01103.1 - 0.08 12.4 0.5 0.082 12.4 0.5 1.1 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Ank_3 PF13606.6 ETO01104.1 - 1.9e-09 36.9 0.2 5.7e-05 23.2 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_2 PF12796.7 ETO01104.1 - 3.1e-07 30.9 0.2 1.4e-06 28.7 0.1 2.1 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO01104.1 - 6.2e-07 29.6 1.4 4.7e-06 26.8 0.1 2.9 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO01104.1 - 3.5e-06 27.4 0.4 1.4e-05 25.5 0.2 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO01104.1 - 1e-05 25.7 0.1 0.00054 20.3 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat DNA_pol_E_B PF04042.16 ETO01104.1 - 0.11 11.8 0.0 0.21 10.9 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B zf-C2H2_4 PF13894.6 ETO01106.1 - 9.8e-05 22.9 15.7 0.054 14.4 4.5 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO01106.1 - 0.013 15.9 7.0 0.9 10.1 3.2 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2 PF00096.26 ETO01106.1 - 0.036 14.5 13.3 0.6 10.7 2.8 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type HypA PF01155.19 ETO01106.1 - 0.066 13.2 0.6 0.32 11.0 0.2 2.3 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Zn-ribbon_8 PF09723.10 ETO01106.1 - 0.3 11.3 3.5 13 6.0 0.2 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-AN1 PF01428.16 ETO01106.1 - 1.3 9.3 13.4 0.22 11.7 2.0 3.5 2 1 1 3 3 3 0 AN1-like Zinc finger zf-C2H2_11 PF16622.5 ETO01106.1 - 8.1 6.3 11.9 7.8 6.4 4.4 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type Toast_rack_N PF17115.5 ETO01108.1 - 0.022 15.0 0.1 0.028 14.7 0.1 1.1 1 0 0 1 1 1 0 N-terminal domain of toast_rack, DUF2154 RTP1_C1 PF10363.9 ETO01109.1 - 0.0035 17.5 0.6 0.062 13.5 0.0 2.2 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ETO01109.1 - 0.0052 17.3 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 HEAT-like repeat DUF999 PF06198.11 ETO01109.1 - 0.029 14.4 0.8 0.048 13.7 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF999) WD40 PF00400.32 ETO01110.1 - 7.6e-08 32.9 6.3 0.00094 19.9 0.3 3.6 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01110.1 - 0.018 13.7 0.1 0.93 8.1 0.1 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ATG27 PF09451.10 ETO01111.1 - 0.095 12.5 0.4 0.59 9.9 0.4 1.9 1 1 0 1 1 1 0 Autophagy-related protein 27 zf-RVT PF13966.6 ETO01112.1 - 0.00077 20.1 0.2 0.0011 19.6 0.2 1.3 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase PSI_integrin PF17205.3 ETO01112.1 - 0.028 14.1 0.4 0.051 13.3 0.4 1.4 1 0 0 1 1 1 0 Integrin plexin domain RecO_N PF11967.8 ETO01112.1 - 0.11 12.5 0.0 0.15 12.1 0.0 1.2 1 0 0 1 1 1 0 Recombination protein O N terminal Tubulin PF00091.25 ETO01115.1 - 2.8e-29 102.7 0.2 2.8e-25 89.7 0.0 2.1 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO01115.1 - 0.0023 17.2 0.0 0.0024 17.1 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Ank_2 PF12796.7 ETO01116.1 - 9.1e-14 51.8 2.0 4.6e-12 46.4 0.4 2.8 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO01116.1 - 9.9e-13 48.3 1.2 1.7e-09 38.0 0.1 3.8 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO01116.1 - 2.3e-09 36.7 4.7 0.042 14.4 0.0 5.1 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 ETO01116.1 - 1.9e-06 28.0 10.2 0.00046 20.4 0.4 3.3 2 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO01116.1 - 2.7e-06 27.5 1.8 0.018 15.5 0.0 4.0 4 0 0 4 4 4 2 Ankyrin repeat FSA_C PF10479.9 ETO01117.1 - 3.5 5.6 7.9 3.4 5.7 7.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 ETO01117.1 - 4.5 7.3 19.2 0.6 10.1 15.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO01117.1 - 5.8 4.8 5.8 6.2 4.7 5.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein WD40 PF00400.32 ETO01118.1 - 1.9e-26 91.8 4.7 4.9e-07 30.3 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01118.1 - 1e-08 35.3 0.2 0.0056 17.0 0.0 3.7 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01118.1 - 0.00021 20.7 0.2 0.0039 16.6 0.1 2.1 1 1 1 2 2 2 2 WD40-like domain DUF1513 PF07433.11 ETO01118.1 - 0.011 14.9 0.0 0.016 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1513) Ge1_WD40 PF16529.5 ETO01118.1 - 0.03 13.3 0.3 15 4.4 0.0 3.3 1 1 3 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO01118.1 - 0.058 12.0 0.8 12 4.5 0.1 2.9 1 1 2 3 3 3 0 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO01118.1 - 0.064 13.1 0.0 0.18 11.7 0.0 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A Pkinase PF00069.25 ETO01119.1 - 0.00012 21.5 0.3 0.00016 21.1 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO01119.1 - 0.015 14.6 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase DUF2457 PF10446.9 ETO01120.1 - 0.0035 16.6 16.5 0.0038 16.4 16.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO01120.1 - 0.12 10.6 10.7 0.13 10.4 10.7 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO01120.1 - 1.3 8.2 12.5 1.5 8.1 12.5 1.1 1 0 0 1 1 1 0 BUD22 eIF-3c_N PF05470.12 ETO01120.1 - 1.7 6.9 7.6 1.9 6.7 7.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 ETO01120.1 - 2.2 6.3 19.5 2.4 6.2 19.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ETO01120.1 - 7.1 7.1 25.8 16 6.0 25.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RRN3 PF05327.11 ETO01120.1 - 9.5 4.6 9.2 9.5 4.6 9.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SR-25 PF10500.9 ETO01123.1 - 0.024 14.2 16.5 0.03 13.9 16.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1149 PF06619.11 ETO01123.1 - 0.033 14.5 0.2 0.062 13.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1149) NACHT PF05729.12 ETO01125.1 - 5.9e-09 36.1 0.0 8.2e-09 35.6 0.0 1.1 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETO01125.1 - 0.055 13.4 1.0 0.66 10.0 0.2 2.6 2 1 0 2 2 2 0 STI1 domain GAS PF13851.6 ETO01126.1 - 5.9e-06 25.8 11.1 5.9e-06 25.8 11.1 2.6 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 ETO01126.1 - 0.00018 21.7 29.1 0.0041 17.3 19.4 2.3 1 1 1 2 2 2 2 Tropomyosin like Seryl_tRNA_N PF02403.22 ETO01126.1 - 0.00073 19.7 7.6 0.00073 19.7 7.6 2.5 1 1 1 2 2 1 1 Seryl-tRNA synthetase N-terminal domain FlxA PF14282.6 ETO01126.1 - 0.00077 19.4 6.5 0.00077 19.4 6.5 2.6 2 1 1 3 3 3 1 FlxA-like protein HAP1_N PF04849.13 ETO01126.1 - 0.0013 18.1 21.1 0.0018 17.6 21.1 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DASH_Hsk3 PF08227.11 ETO01126.1 - 0.0017 18.6 5.6 0.04 14.3 0.0 3.1 3 0 0 3 3 2 1 DASH complex subunit Hsk3 like bZIP_1 PF00170.21 ETO01126.1 - 0.0023 18.0 23.3 0.022 14.9 1.5 3.8 2 2 0 2 2 2 1 bZIP transcription factor FlaC_arch PF05377.11 ETO01126.1 - 0.0045 17.4 14.4 0.71 10.3 2.6 3.7 1 1 3 4 4 4 2 Flagella accessory protein C (FlaC) DUF3450 PF11932.8 ETO01126.1 - 0.0084 15.4 9.4 0.0084 15.4 9.4 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3450) Uso1_p115_C PF04871.13 ETO01126.1 - 0.014 15.7 8.0 0.014 15.7 8.0 2.5 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Fib_alpha PF08702.10 ETO01126.1 - 0.016 15.4 5.9 0.016 15.4 5.9 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 ETO01126.1 - 0.026 15.0 9.0 5.3 7.6 0.2 3.3 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein JIP_LZII PF16471.5 ETO01126.1 - 0.028 14.6 1.0 0.028 14.6 1.0 3.7 2 1 2 4 4 3 0 JNK-interacting protein leucine zipper II HOOK PF05622.12 ETO01126.1 - 0.03 12.5 27.8 0.12 10.5 27.8 1.8 1 1 0 1 1 1 0 HOOK protein RmuC PF02646.16 ETO01126.1 - 0.037 13.2 1.0 0.037 13.2 1.0 3.0 1 1 2 3 3 2 0 RmuC family CENP-F_leu_zip PF10473.9 ETO01126.1 - 0.038 14.0 29.0 0.038 14.0 7.2 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Baculo_PEP_C PF04513.12 ETO01126.1 - 0.051 13.6 2.0 0.21 11.6 2.0 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Spc7 PF08317.11 ETO01126.1 - 0.068 12.0 29.7 0.074 11.9 7.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 ETO01126.1 - 0.074 13.3 4.3 3.4 8.0 0.9 3.0 1 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 ETO01126.1 - 0.1 12.9 26.3 0.11 12.7 2.9 3.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_L PF02601.15 ETO01126.1 - 0.11 12.0 16.6 0.14 11.7 16.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit EzrA PF06160.12 ETO01126.1 - 0.15 10.2 22.9 0.4 8.8 14.9 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA MAD PF05557.13 ETO01126.1 - 0.16 10.3 28.2 0.19 10.0 28.2 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein YabA PF06156.13 ETO01126.1 - 0.17 12.5 19.9 0.2 12.3 3.2 3.4 1 1 1 3 3 3 0 Initiation control protein YabA Lectin_N PF03954.14 ETO01126.1 - 0.18 11.6 15.4 0.078 12.7 4.2 2.3 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF724 PF05266.14 ETO01126.1 - 0.22 11.3 27.7 0.063 13.1 19.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) PEARLI-4 PF05278.12 ETO01126.1 - 0.33 10.5 23.0 0.17 11.5 3.4 2.1 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) UPF0242 PF06785.11 ETO01126.1 - 0.38 10.8 25.1 0.74 9.9 25.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Phlebovirus_NSM PF07246.11 ETO01126.1 - 0.47 9.8 16.7 0.13 11.6 13.2 1.7 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M Matrilin_ccoil PF10393.9 ETO01126.1 - 0.51 10.2 6.5 4.5 7.2 0.4 3.2 2 1 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Fzo_mitofusin PF04799.13 ETO01126.1 - 0.58 9.7 15.4 0.58 9.7 8.3 2.5 1 1 1 2 2 2 0 fzo-like conserved region Mod_r PF07200.13 ETO01126.1 - 0.64 10.1 25.2 0.23 11.6 4.5 2.4 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Laminin_II PF06009.12 ETO01126.1 - 0.69 9.9 16.5 0.026 14.5 2.8 2.7 1 1 1 2 2 2 0 Laminin Domain II ATG16 PF08614.11 ETO01126.1 - 0.78 9.9 27.2 73 3.5 27.2 2.2 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Cnn_1N PF07989.11 ETO01126.1 - 0.79 9.9 26.6 0.26 11.5 7.5 3.3 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 HemX PF04375.14 ETO01126.1 - 0.81 8.9 23.9 0.31 10.3 5.9 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase ADIP PF11559.8 ETO01126.1 - 0.84 9.7 28.0 0.048 13.7 5.8 2.3 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 ETO01126.1 - 0.93 10.2 24.1 2.9 8.6 1.3 4.1 1 1 3 4 4 4 0 SlyX APG6_N PF17675.1 ETO01126.1 - 1.1 9.8 29.8 0.35 11.4 4.0 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF2203 PF09969.9 ETO01126.1 - 1.5 9.5 18.3 1.5 9.6 3.3 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) XhlA PF10779.9 ETO01126.1 - 1.7 8.9 19.9 1.1 9.5 1.7 3.9 1 1 2 3 3 2 0 Haemolysin XhlA MbeD_MobD PF04899.12 ETO01126.1 - 1.8 8.7 12.4 2 8.6 2.2 3.4 1 1 2 3 3 3 0 MbeD/MobD like KASH_CCD PF14662.6 ETO01126.1 - 2.1 8.2 28.8 0.17 11.7 8.7 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Fez1 PF06818.15 ETO01126.1 - 2.5 8.5 24.5 13 6.1 24.5 1.8 1 1 0 1 1 1 0 Fez1 Cellulose_synt PF03552.14 ETO01126.1 - 2.8 6.3 6.9 3.4 6.0 6.9 1.0 1 0 0 1 1 1 0 Cellulose synthase DUF1664 PF07889.12 ETO01126.1 - 2.9 8.0 18.4 0.2 11.7 5.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ETO01126.1 - 3.4 7.0 20.2 23 4.2 20.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) EMP24_GP25L PF01105.24 ETO01126.1 - 3.7 7.5 14.5 2.3 8.1 7.6 2.8 1 1 2 3 3 3 0 emp24/gp25L/p24 family/GOLD Cauli_AT PF03233.13 ETO01126.1 - 3.7 7.4 17.7 0.046 13.7 4.4 2.2 1 1 1 2 2 2 0 Aphid transmission protein DUF1515 PF07439.11 ETO01126.1 - 3.8 7.6 11.8 0.33 11.0 1.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Noelin-1 PF12308.8 ETO01126.1 - 4.2 7.4 10.0 1.6 8.7 1.6 2.7 1 1 3 4 4 3 0 Neurogenesis glycoprotein DUF5082 PF16888.5 ETO01126.1 - 4.6 7.5 22.1 5.1 7.4 1.9 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF5082) Jnk-SapK_ap_N PF09744.9 ETO01126.1 - 4.8 7.4 28.0 1.3e+03 -0.6 28.0 2.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4201 PF13870.6 ETO01126.1 - 7.1 6.3 29.0 75 3.0 29.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) GIT_CC PF16559.5 ETO01126.1 - 7.9 6.4 18.9 1.4 8.9 1.3 4.0 1 1 2 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF572 PF04502.13 ETO01126.1 - 8.4 5.9 18.0 10 5.6 18.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) T3SSipB PF16535.5 ETO01126.1 - 9.4 6.7 20.3 3 8.3 5.2 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB Spc24 PF08286.11 ETO01126.1 - 9.4 6.5 27.0 0.97 9.7 2.0 3.6 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Roc PF08477.13 ETO01127.1 - 0.026 14.7 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO01127.1 - 0.13 11.9 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Ras family Ribosomal_S8e PF01201.22 ETO01127.1 - 0.17 12.1 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S8e TPR_12 PF13424.6 ETO01128.1 - 4.7e-30 103.7 0.1 8.8e-19 67.6 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01128.1 - 8.3e-21 73.2 0.1 7.9e-10 38.3 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01128.1 - 5e-17 60.9 6.4 8.5e-09 34.9 0.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01128.1 - 1.8e-16 58.8 1.8 8e-08 31.8 0.0 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01128.1 - 6.7e-15 54.0 9.5 6.1e-08 32.3 0.9 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01128.1 - 7.5e-13 47.5 2.6 1.2e-05 25.1 0.1 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01128.1 - 3.7e-08 32.9 9.9 0.0009 18.9 0.3 3.5 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 ETO01128.1 - 2.8e-07 31.1 0.0 0.002 18.7 0.0 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01128.1 - 3.1e-07 30.3 0.7 0.0019 18.5 0.1 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO01128.1 - 1.3e-06 28.3 0.8 0.039 13.9 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01128.1 - 3.6e-06 27.3 0.0 0.09 13.6 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 ETO01128.1 - 2.9e-05 24.1 3.7 0.014 15.5 0.3 2.1 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO01128.1 - 8.4e-05 22.6 3.5 0.013 15.7 0.1 2.4 3 0 0 3 3 2 2 PPR repeat TPR_6 PF13174.6 ETO01128.1 - 0.00013 22.4 0.0 0.62 10.8 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO01128.1 - 0.003 17.0 0.0 0.0031 16.9 0.0 1.0 1 0 0 1 1 1 1 MalT-like TPR region TPR_19 PF14559.6 ETO01128.1 - 0.0067 16.9 0.0 0.012 16.1 0.0 1.6 1 1 0 1 1 1 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO01128.1 - 0.011 15.6 0.3 0.41 10.4 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) HTH_Bact PF18768.1 ETO01128.1 - 0.013 15.0 2.8 0.71 9.5 0.2 3.3 2 2 2 4 4 4 0 Helix-turn-helix bacterial domain ATP-synt_E_2 PF08112.11 ETO01128.1 - 0.017 15.4 0.8 3.3 8.1 0.1 2.3 2 0 0 2 2 2 0 ATP synthase epsilon subunit SNAP PF14938.6 ETO01128.1 - 0.02 14.3 1.7 0.26 10.7 1.8 1.9 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP Clathrin PF00637.20 ETO01128.1 - 0.024 14.5 0.2 4.1 7.3 0.0 2.2 2 0 0 2 2 2 0 Region in Clathrin and VPS SHNi-TPR PF10516.9 ETO01128.1 - 0.026 14.0 0.1 2.1 7.9 0.0 2.3 2 0 0 2 2 2 0 SHNi-TPR ANAPC3 PF12895.7 ETO01128.1 - 0.028 14.6 0.2 0.04 14.1 0.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.7 ETO01128.1 - 0.034 14.4 0.0 7.2 6.9 0.0 2.1 1 1 1 2 2 2 0 Tetratrico peptide repeat Sel1 PF08238.12 ETO01128.1 - 0.04 14.6 2.5 6.4 7.6 0.1 2.8 3 0 0 3 3 3 0 Sel1 repeat KapB PF08810.10 ETO01128.1 - 0.057 13.6 0.9 4.7 7.4 0.1 2.0 1 1 1 2 2 2 0 Kinase associated protein B Cnd1 PF12717.7 ETO01129.1 - 0.073 13.1 3.7 0.087 12.9 0.1 2.5 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 Phage_TAC_3 PF06896.11 ETO01129.1 - 0.086 13.4 0.1 0.54 10.9 0.1 2.2 2 0 0 2 2 2 0 Phage tail assembly chaperone proteins, TAC MAS20 PF02064.15 ETO01130.1 - 2.4 8.3 10.8 4 7.5 0.6 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor TFIIA PF03153.13 ETO01130.1 - 5.2 6.9 25.0 7.6 6.4 25.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Rsbr_N PF08678.10 ETO01131.1 - 0.0091 16.1 2.7 0.01 15.9 0.7 2.1 2 0 0 2 2 2 1 Rsbr N terminal FliS PF02561.14 ETO01131.1 - 0.23 11.8 3.8 0.29 11.4 0.4 2.8 1 1 1 2 2 2 0 Flagellar protein FliS DASH_Dad1 PF08649.10 ETO01131.1 - 1.2 9.4 5.9 0.31 11.3 0.2 3.1 3 1 0 3 3 3 0 DASH complex subunit Dad1 ASFV_p27 PF06556.11 ETO01132.1 - 0.067 13.3 0.1 0.078 13.1 0.1 1.1 1 0 0 1 1 1 0 IAP-like protein p27 C-terminus HEAT PF02985.22 ETO01133.1 - 3.7e-17 61.0 0.3 0.018 15.3 0.0 6.5 6 0 0 6 6 6 4 HEAT repeat HEAT_EZ PF13513.6 ETO01133.1 - 4.2e-13 49.5 0.0 0.28 11.7 0.0 6.8 5 2 2 7 7 7 3 HEAT-like repeat HEAT_2 PF13646.6 ETO01133.1 - 1.7e-10 41.1 0.0 0.019 15.4 0.0 5.2 4 2 2 6 6 5 4 HEAT repeats Cnd1 PF12717.7 ETO01133.1 - 9.5e-10 38.7 20.2 0.0001 22.4 0.1 6.0 2 1 4 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO01133.1 - 1.1e-07 32.4 4.8 0.1 13.2 0.1 4.9 2 2 3 5 5 5 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO01133.1 - 4.7e-07 29.6 4.4 0.14 11.7 0.1 4.5 2 1 1 5 5 5 3 CLASP N terminal RTP1_C1 PF10363.9 ETO01133.1 - 1.6e-05 25.0 0.2 0.36 11.0 0.0 4.8 3 2 0 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 IFRD PF05004.13 ETO01133.1 - 9.1e-05 21.7 0.7 0.097 11.8 0.1 3.2 2 1 1 3 3 3 2 Interferon-related developmental regulator (IFRD) SAC3_GANP PF03399.16 ETO01133.1 - 0.044 13.2 5.4 5.8 6.2 0.0 4.2 3 1 0 4 4 4 0 SAC3/GANP family Methyltransf_4 PF02390.17 ETO01133.1 - 0.094 12.2 5.1 3.6 7.0 0.1 3.3 3 0 0 3 3 3 0 Putative methyltransferase SASA PF03629.18 ETO01133.1 - 0.097 12.3 0.4 0.21 11.2 0.4 1.5 1 0 0 1 1 1 0 Carbohydrate esterase, sialic acid-specific acetylesterase RNA_binding PF01877.17 ETO01133.1 - 0.1 12.9 14.1 13 6.1 0.0 6.4 3 3 3 7 7 7 0 RNA binding MgtE_N PF03448.17 ETO01133.1 - 0.18 12.4 1.5 31 5.3 0.0 3.1 3 0 0 3 3 3 0 MgtE intracellular N domain Imm3 PF14425.6 ETO01134.1 - 0.087 12.9 1.5 0.13 12.3 1.1 1.5 1 1 0 1 1 1 0 Immunity protein Imm3 Tfb5 PF06331.12 ETO01134.1 - 0.17 11.9 1.5 0.35 10.9 1.5 1.5 1 0 0 1 1 1 0 Transcription factor TFIIH complex subunit Tfb5 Fringe PF02434.16 ETO01135.1 - 0.025 14.0 0.1 0.035 13.5 0.1 1.2 1 0 0 1 1 1 0 Fringe-like Raftlin PF15250.6 ETO01135.1 - 0.068 11.9 4.8 0.083 11.6 4.8 1.0 1 0 0 1 1 1 0 Raftlin Actin PF00022.19 ETO01136.1 - 4.9e-57 193.4 0.0 3.1e-55 187.4 0.0 2.0 1 1 0 1 1 1 1 Actin WD40 PF00400.32 ETO01137.1 - 3.2e-07 30.9 1.3 7.8e-07 29.7 0.0 2.2 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01137.1 - 0.035 14.4 0.1 0.049 13.9 0.1 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain PPR_2 PF13041.6 ETO01138.1 - 3e-11 43.3 7.4 0.0058 16.8 0.0 5.0 3 1 2 5 5 5 3 PPR repeat family PPR PF01535.20 ETO01138.1 - 6.1e-11 41.8 4.7 0.01 16.1 0.0 5.2 4 0 0 4 4 4 3 PPR repeat PPR_1 PF12854.7 ETO01138.1 - 1.6e-06 27.7 1.2 0.088 12.5 0.0 3.5 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.6 ETO01138.1 - 7.7e-05 22.7 0.6 0.036 14.1 0.1 3.4 1 1 2 3 3 3 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO01138.1 - 0.0022 17.4 0.5 0.008 15.6 0.3 1.9 1 1 1 2 2 2 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO01138.1 - 0.0024 17.7 0.4 0.012 15.4 0.2 2.4 1 1 0 1 1 1 1 Mitochondrial ATPase expression Utp21 PF04192.12 ETO01138.1 - 0.14 11.7 5.4 0.062 12.8 2.4 2.0 2 0 0 2 2 2 0 Utp21 specific WD40 associated putative domain FAM76 PF16046.5 ETO01139.1 - 0.005 16.3 18.3 0.0082 15.5 18.3 1.5 1 1 0 1 1 1 1 FAM76 protein Gp58 PF07902.11 ETO01139.1 - 0.055 11.7 6.8 0.072 11.4 6.8 1.1 1 0 0 1 1 1 0 gp58-like protein LMBR1 PF04791.16 ETO01139.1 - 0.97 8.3 5.6 1.1 8.1 5.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Lipoprotein_3 PF00938.17 ETO01139.1 - 2.6 8.3 12.5 0.28 11.4 2.9 2.8 2 1 0 3 3 3 0 Lipoprotein Actin PF00022.19 ETO01140.1 - 7.3e-24 84.1 0.0 8.2e-24 84.0 0.0 1.0 1 0 0 1 1 1 1 Actin Kelch_1 PF01344.25 ETO01141.1 - 1.8e-07 30.6 6.1 1.3e-05 24.6 1.4 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO01141.1 - 0.00025 21.2 7.1 2.1 8.8 0.9 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO01141.1 - 0.0022 17.9 12.2 0.36 10.9 1.6 5.0 5 2 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO01141.1 - 0.0031 17.8 0.4 0.21 11.9 0.1 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01141.1 - 0.019 15.0 9.0 0.034 14.1 1.0 4.6 6 0 0 6 6 6 0 Kelch motif MVL PF12151.8 ETO01141.1 - 0.21 11.5 0.8 0.49 10.3 0.8 1.6 1 0 0 1 1 1 0 Mannan-binding protein DUF1664 PF07889.12 ETO01142.1 - 0.056 13.5 14.0 0.97 9.5 6.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 ETO01142.1 - 0.22 11.8 27.2 0.36 11.1 8.2 3.2 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.9 ETO01142.1 - 0.27 11.5 19.4 0.042 14.1 8.0 2.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 ETO01142.1 - 0.39 9.6 32.8 0.1 11.5 15.2 2.7 1 1 2 3 3 3 0 Spc7 kinetochore protein Syntaxin-6_N PF09177.11 ETO01142.1 - 0.66 10.6 17.4 3.1 8.4 3.9 3.3 1 1 0 2 2 2 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.12 ETO01142.1 - 0.9 9.6 35.0 0.17 12.0 7.7 3.1 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein FliJ PF02050.16 ETO01142.1 - 2.4 8.4 31.3 1.6 9.0 8.2 3.1 2 1 1 3 3 3 0 Flagellar FliJ protein DUF4200 PF13863.6 ETO01142.1 - 3.4 8.1 32.6 3.3 8.2 18.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) DUF3584 PF12128.8 ETO01142.1 - 3.8 4.9 27.2 4.6 4.6 27.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4201 PF13870.6 ETO01142.1 - 4.8 6.9 28.1 0.18 11.6 11.4 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Ribosomal_60s PF00428.19 ETO01143.1 - 0.00017 22.1 10.8 0.00017 22.1 10.8 2.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein RskA PF10099.9 ETO01143.1 - 0.056 13.7 6.7 0.081 13.2 6.7 1.2 1 0 0 1 1 1 0 Anti-sigma-K factor rskA DUF3235 PF11574.8 ETO01143.1 - 0.061 14.2 7.1 0.1 13.4 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) Glyco_hydro_3_C PF01915.22 ETO01143.1 - 4 7.3 6.5 0.49 10.3 2.6 1.4 1 1 1 2 2 2 0 Glycosyl hydrolase family 3 C-terminal domain SPARC_Ca_bdg PF10591.9 ETO01146.1 - 0.0016 18.7 0.7 0.0016 18.7 0.7 2.4 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_10 PF14788.6 ETO01146.1 - 0.08 12.8 0.2 0.47 10.4 0.0 2.4 2 0 0 2 2 2 0 EF hand PQQ PF01011.21 ETO01146.1 - 0.15 12.1 0.1 8.7 6.5 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat CYTL1 PF15153.6 ETO01146.1 - 1.4 8.9 4.6 3.3 7.7 1.1 2.7 2 1 1 3 3 3 0 Cytokine-like protein 1 PheRS_DBD1 PF18552.1 ETO01147.1 - 0.031 14.0 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 PheRS DNA binding domain 1 FdsD PF11390.8 ETO01149.1 - 0.039 14.3 0.0 0.071 13.4 0.0 1.4 1 0 0 1 1 1 0 NADH-dependant formate dehydrogenase delta subunit FdsD Peptidase_C14 PF00656.22 ETO01151.1 - 9.2e-05 22.5 0.1 0.00015 21.9 0.1 1.3 1 0 0 1 1 1 1 Caspase domain WD40 PF00400.32 ETO01153.1 - 1.2e-24 86.1 14.0 2.2e-11 44.1 0.1 5.3 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01153.1 - 1.8e-10 40.9 0.8 8e-05 22.9 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO01153.1 - 2e-07 30.3 0.0 0.00068 18.7 0.0 2.9 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO01153.1 - 0.00027 19.8 0.3 0.0054 15.4 0.0 2.4 2 1 1 3 3 3 1 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO01153.1 - 0.00068 19.6 0.0 0.0014 18.6 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO01153.1 - 0.0012 17.5 0.3 0.065 11.8 0.1 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO01153.1 - 0.0016 18.3 0.8 9.3 6.3 0.0 3.3 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO01153.1 - 0.0083 14.9 0.7 0.025 13.3 0.7 1.9 1 1 0 1 1 1 1 Nup133 N terminal like WD40_like PF17005.5 ETO01153.1 - 0.023 14.0 0.0 1.7 7.9 0.0 2.1 1 1 1 2 2 2 0 WD40-like domain WD40 PF00400.32 ETO01155.1 - 8.1e-13 48.6 11.2 3.2e-05 24.6 0.3 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat WD40_like PF17005.5 ETO01155.1 - 0.001 18.5 0.5 0.37 10.1 0.1 2.4 1 1 2 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 ETO01155.1 - 0.0044 17.3 1.1 8.3 6.8 0.4 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01155.1 - 0.013 14.1 3.2 0.28 9.8 3.2 2.3 1 1 0 1 1 1 0 Nucleoporin Nup120/160 WYL_2 PF10902.8 ETO01155.1 - 0.12 12.7 0.4 3.6 8.0 0.2 2.3 2 0 0 2 2 2 0 WYL_2, Sm-like SH3 beta-barrel fold W_rich_C PF07483.11 ETO01155.1 - 0.5 10.5 6.7 4.9 7.4 0.5 2.6 1 1 1 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain RGS PF00615.19 ETO01156.1 - 2.6e-05 24.5 0.1 6.1e-05 23.3 0.1 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Protoglobin PF11563.8 ETO01156.1 - 0.0057 16.6 0.0 0.0085 16.0 0.0 1.4 1 0 0 1 1 1 1 Protoglobin ubiquitin PF00240.23 ETO01158.1 - 6e-21 74.0 0.0 2.7e-17 62.3 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETO01158.1 - 8.9e-09 35.1 0.0 3.2e-06 26.9 0.0 2.3 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 ETO01158.1 - 0.049 14.3 0.0 0.26 12.0 0.0 2.1 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukD Helo_like_N PF17111.5 ETO01159.1 - 0.012 15.0 1.9 0.012 15.0 1.9 1.3 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins tRNA_synt_1c_R1 PF04558.15 ETO01159.1 - 0.022 14.8 0.3 0.037 14.0 0.3 1.4 1 0 0 1 1 1 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 1 Rsd_AlgQ PF04353.13 ETO01159.1 - 0.081 12.9 1.0 0.12 12.3 1.0 1.2 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DUF3627 PF12299.8 ETO01159.1 - 1.8 8.7 9.0 17 5.6 6.7 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3627) WD40 PF00400.32 ETO01160.1 - 2.3e-19 69.3 6.4 6.7e-08 33.1 0.1 3.9 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01160.1 - 8.4e-08 32.4 0.1 0.076 13.3 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01160.1 - 2.5e-06 26.5 1.4 0.0037 16.0 0.2 2.6 1 1 1 3 3 3 2 Nucleoporin Nup120/160 GKAP PF03359.13 ETO01160.1 - 0.11 12.0 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein Aminotran_5 PF00266.19 ETO01162.1 - 6.3e-23 81.3 0.2 1.1e-22 80.5 0.2 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Ank_3 PF13606.6 ETO01163.1 - 0.024 15.1 0.4 0.1 13.2 0.1 2.1 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 ETO01163.1 - 0.054 14.1 0.1 0.12 13.0 0.0 1.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) WD40 PF00400.32 ETO01164.1 - 0.00028 21.6 1.1 0.004 18.0 0.9 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat Dna2 PF08696.11 ETO01165.1 - 8.2e-14 51.9 0.1 1.3e-13 51.2 0.1 1.3 1 0 0 1 1 1 1 DNA replication factor Dna2 MG4 PF17789.1 ETO01165.1 - 0.01 15.9 0.2 0.022 14.9 0.2 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG4 Cas_Cas4 PF01930.17 ETO01165.1 - 0.03 14.4 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function DUF83 PDDEXK_1 PF12705.7 ETO01165.1 - 0.034 14.1 0.1 0.13 12.2 0.1 1.9 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily WD40 PF00400.32 ETO01166.1 - 3.5e-16 59.3 4.1 1.1e-07 32.3 0.3 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01166.1 - 1.7e-06 27.0 0.4 0.0049 15.6 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01166.1 - 0.00098 19.4 0.0 0.34 11.2 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1481 PF07356.12 ETO01166.1 - 0.048 13.4 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1481) CAMSAP_CH PF11971.8 ETO01169.1 - 0.00014 21.7 0.1 0.00029 20.6 0.1 1.5 1 0 0 1 1 1 1 CAMSAP CH domain CH_2 PF06294.11 ETO01169.1 - 0.00016 21.7 0.8 0.00034 20.7 0.8 1.6 2 0 0 2 2 2 1 CH-like domain in sperm protein CH PF00307.31 ETO01169.1 - 0.00026 21.1 0.7 0.00026 21.1 0.7 2.0 2 1 0 2 2 2 1 Calponin homology (CH) domain DUF1616 PF07760.11 ETO01170.1 - 0.0087 15.5 0.0 0.0092 15.4 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1616) MIEAP PF16026.5 ETO01171.1 - 0.052 13.8 0.1 0.26 11.5 0.0 2.1 2 0 0 2 2 2 0 Mitochondria-eating protein IZUMO PF15005.6 ETO01173.1 - 0.077 13.5 1.4 1.9 9.0 0.2 1.9 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated 2OG-FeII_Oxy_3 PF13640.6 ETO01174.1 - 0.0071 17.2 0.0 0.017 16.0 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily HSP70 PF00012.20 ETO01175.1 - 7.3e-43 146.6 3.0 1.5e-23 82.9 0.2 3.0 2 1 1 3 3 3 3 Hsp70 protein DUF3819 PF12842.7 ETO01176.1 - 0.039 13.9 0.2 0.056 13.4 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) TatD_DNase PF01026.21 ETO01178.1 - 2.4e-30 105.8 0.1 3.1e-30 105.4 0.1 1.1 1 0 0 1 1 1 1 TatD related DNase Collectrin PF16959.5 ETO01179.1 - 0.0021 17.8 0.3 0.0051 16.6 0.0 1.8 2 0 0 2 2 2 1 Renal amino acid transporter ubiquitin PF00240.23 ETO01179.1 - 0.011 15.5 0.8 0.02 14.6 0.0 1.8 2 0 0 2 2 2 0 Ubiquitin family Ubiquitin_5 PF18037.1 ETO01179.1 - 0.054 13.9 0.0 0.2 12.0 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-like domain SAM_Ste50p PF09235.10 ETO01180.1 - 4.6e-06 26.8 3.8 3.2e-05 24.1 0.3 2.7 1 1 1 2 2 2 1 Ste50p, sterile alpha motif TUG-UBL1 PF11470.8 ETO01180.1 - 0.0034 17.6 0.1 0.0096 16.1 0.0 1.8 2 0 0 2 2 2 1 TUG ubiquitin-like domain DUF4193 PF13834.6 ETO01180.1 - 0.17 12.4 1.2 0.52 10.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4193) Kelch_1 PF01344.25 ETO01181.1 - 0.15 11.7 0.4 1.3 8.7 0.1 2.6 3 0 0 3 3 3 0 Kelch motif IBR PF01485.21 ETO01182.1 - 0.018 15.2 23.9 0.034 14.4 16.9 3.4 1 1 0 2 2 2 0 IBR domain, a half RING-finger domain ASL_C PF08328.11 ETO01182.1 - 0.097 12.8 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal UCH PF00443.29 ETO01183.1 - 8.3e-08 32.0 0.1 2.2e-07 30.7 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2232 PF09991.9 ETO01183.1 - 0.037 13.2 2.3 0.053 12.7 2.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) Zip PF02535.22 ETO01183.1 - 0.067 12.4 1.1 0.28 10.4 0.0 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4010 PF13194.6 ETO01184.1 - 0.043 13.5 0.0 0.056 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4010) DUF3099 PF11298.8 ETO01184.1 - 0.14 12.3 3.4 0.34 11.1 3.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3099) VWA PF00092.28 ETO01187.1 - 0.007 16.6 0.0 0.0078 16.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO01187.1 - 0.0091 16.6 0.0 0.015 16.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ETO01187.1 - 0.079 13.1 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 vWA found in TerF C terminus iPGM_N PF06415.13 ETO01187.1 - 0.089 12.2 0.0 0.17 11.3 0.0 1.4 1 0 0 1 1 1 0 BPG-independent PGAM N-terminus (iPGM_N) Astro_capsid_p PF12226.8 ETO01188.1 - 0.015 14.5 0.4 0.023 13.9 0.4 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein LRR_4 PF12799.7 ETO01188.1 - 4.2 7.9 8.6 24 5.5 1.6 4.4 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) MUG113 PF13455.6 ETO01190.1 - 0.063 14.0 0.6 0.14 12.8 0.6 1.7 1 1 0 1 1 1 0 Meiotically up-regulated gene 113 Orf78 PF06024.12 ETO01190.1 - 0.63 10.4 3.5 1 9.7 3.5 1.3 1 0 0 1 1 1 0 Orf78 (ac78) TPR_12 PF13424.6 ETO01191.1 - 9.8e-39 131.5 13.1 8.9e-18 64.4 1.1 2.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01191.1 - 4.9e-25 86.6 2.8 5.2e-10 38.9 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01191.1 - 5.5e-24 83.0 14.9 4.5e-09 35.7 1.1 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01191.1 - 1.6e-21 74.6 3.8 1.3e-07 31.2 0.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01191.1 - 8.1e-16 56.9 13.0 8.4e-07 28.7 0.4 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01191.1 - 8.1e-16 56.8 10.5 1.6e-06 27.8 0.3 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01191.1 - 4.8e-10 39.1 3.6 0.01 16.2 0.1 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01191.1 - 3.1e-06 27.4 0.5 0.36 11.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01191.1 - 7.6e-06 26.5 0.1 0.1 13.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01191.1 - 7.6e-05 22.3 19.5 0.14 11.9 0.1 5.6 3 3 3 6 6 6 3 TPR repeat DUF5113 PF17140.4 ETO01191.1 - 8.3e-05 22.4 3.9 0.63 9.8 0.1 3.0 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO01191.1 - 0.00012 22.5 0.1 0.87 10.6 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO01191.1 - 0.00049 20.1 10.0 0.067 13.3 0.3 3.1 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO01191.1 - 0.01 15.6 0.4 0.014 15.1 0.4 1.2 1 0 0 1 1 1 1 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 ETO01191.1 - 0.012 15.7 7.0 0.73 9.9 0.5 3.0 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SNAP PF14938.6 ETO01191.1 - 0.013 14.9 1.1 0.025 14.0 1.1 1.4 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP SPO22 PF08631.10 ETO01191.1 - 0.037 13.5 0.5 0.1 12.1 0.4 1.9 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like DUF386 PF04074.12 ETO01191.1 - 0.059 13.3 2.9 0.068 13.1 2.9 1.2 1 0 0 1 1 1 0 YhcH/YjgK/YiaL HTH_Bact PF18768.1 ETO01191.1 - 0.22 11.1 3.5 6.2 6.5 0.0 3.9 4 0 0 4 4 4 0 Helix-turn-helix bacterial domain TPR_3 PF07720.12 ETO01191.1 - 0.25 11.4 9.0 3.1 7.9 0.3 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO01191.1 - 0.52 11.1 6.7 17 6.3 0.1 3.7 3 1 0 3 3 3 0 Sel1 repeat Ubiq-assoc PF09145.10 ETO01191.1 - 7.4 6.7 9.9 12 6.0 0.4 4.2 3 3 1 4 4 4 0 Ubiquitin-associated DUF3402 PF11882.8 ETO01192.1 - 1.8e-20 73.5 12.3 1.3e-17 64.1 2.8 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF3402) DUF913 PF06025.12 ETO01192.1 - 0.13 11.2 1.9 0.2 10.6 0.2 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO01193.1 - 1.2 7.8 8.9 1.5 7.6 8.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NOA36 PF06524.12 ETO01193.1 - 8.8 5.6 15.6 14 4.9 15.6 1.4 1 0 0 1 1 1 0 NOA36 protein PRA1 PF03208.19 ETO01194.1 - 0.075 12.7 1.5 0.14 11.8 1.5 1.5 1 0 0 1 1 1 0 PRA1 family protein TMEM234 PF10639.9 ETO01194.1 - 0.1 12.6 3.0 1.1 9.3 0.4 2.4 1 1 1 2 2 2 0 Putative transmembrane family 234 zf-TRAF PF02176.18 ETO01195.1 - 2.9e-06 27.9 9.7 7.4e-06 26.6 8.5 2.5 1 1 0 1 1 1 1 TRAF-type zinc finger FAM76 PF16046.5 ETO01196.1 - 0.33 10.3 12.4 0.48 9.7 12.4 1.3 1 0 0 1 1 1 0 FAM76 protein MRP-S31 PF15433.6 ETO01196.1 - 1 8.9 13.1 1.1 8.9 13.1 1.2 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 CPP1-like PF11833.8 ETO01196.1 - 1.2 8.8 6.1 1.5 8.4 5.3 1.6 1 1 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Utp14 PF04615.13 ETO01196.1 - 2.3 6.7 19.8 2.4 6.6 19.8 1.0 1 0 0 1 1 1 0 Utp14 protein Kelch_4 PF13418.6 ETO01197.1 - 1.7e-05 24.8 0.3 0.0063 16.5 0.1 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01197.1 - 0.0022 17.5 0.6 0.072 12.7 0.4 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO01197.1 - 0.091 13.1 0.1 3.3 8.1 0.1 2.4 1 1 1 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO01197.1 - 0.17 11.9 3.9 0.22 11.6 0.8 2.7 3 0 0 3 3 3 0 Kelch motif Sigma_reg_N PF13800.6 ETO01197.1 - 2.6 8.4 7.5 0.12 12.7 1.1 2.0 3 0 0 3 3 3 0 Sigma factor regulator N-terminal MHYT PF03707.16 ETO01201.1 - 0.47 10.7 7.5 1.4 9.1 1.8 2.6 1 1 1 2 2 2 0 Bacterial signalling protein N terminal repeat SR-25 PF10500.9 ETO01203.1 - 0.0014 18.3 20.4 0.0022 17.7 20.4 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Med19 PF10278.9 ETO01203.1 - 0.0028 17.6 17.8 0.0054 16.7 17.8 1.5 1 0 0 1 1 1 1 Mediator of RNA pol II transcription subunit 19 Dicty_REP PF05086.12 ETO01203.1 - 0.0047 15.0 5.3 0.0051 14.9 5.3 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 ETO01203.1 - 0.0082 14.9 9.9 0.0092 14.8 9.9 1.1 1 0 0 1 1 1 1 Presenilin DDHD PF02862.17 ETO01203.1 - 0.0092 16.2 6.3 0.011 16.0 6.3 1.2 1 0 0 1 1 1 1 DDHD domain Dsh_C PF12316.8 ETO01203.1 - 0.011 16.1 3.3 0.016 15.6 3.3 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4746 PF15928.5 ETO01203.1 - 0.014 14.9 12.9 0.02 14.3 12.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Tim54 PF11711.8 ETO01203.1 - 0.016 14.0 7.3 0.022 13.6 7.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 ETO01203.1 - 0.018 13.9 10.1 0.02 13.7 10.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM220 PF15487.6 ETO01203.1 - 0.019 14.6 6.8 0.023 14.3 6.8 1.1 1 0 0 1 1 1 0 FAM220 family GEMIN8 PF15348.6 ETO01203.1 - 0.04 14.2 12.0 0.059 13.7 12.0 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 V_ATPase_I PF01496.19 ETO01203.1 - 0.054 11.4 7.3 0.067 11.1 7.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Rota_VP2 PF05087.12 ETO01203.1 - 0.072 11.2 3.9 0.098 10.8 3.9 1.3 1 0 0 1 1 1 0 Rotavirus VP2 protein DUF908 PF06012.12 ETO01203.1 - 0.14 11.5 9.4 0.18 11.2 9.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Zip PF02535.22 ETO01203.1 - 0.24 10.6 10.3 0.32 10.2 10.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ETO01203.1 - 0.33 10.9 9.3 0.55 10.2 9.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Cellulose_synt PF03552.14 ETO01203.1 - 0.46 8.9 1.4 0.48 8.8 1.4 1.1 1 0 0 1 1 1 0 Cellulose synthase GAGA_bind PF06217.12 ETO01203.1 - 0.63 10.3 10.1 0.74 10.0 10.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hid1 PF12722.7 ETO01203.1 - 0.69 8.0 10.8 0.75 7.9 10.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 ETO01203.1 - 0.69 9.9 5.8 0.83 9.7 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 ETO01203.1 - 0.76 8.4 4.7 0.77 8.4 4.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spore_coat_CotO PF14153.6 ETO01203.1 - 0.81 9.6 15.8 1.1 9.2 15.8 1.2 1 0 0 1 1 1 0 Spore coat protein CotO ALMT PF11744.8 ETO01203.1 - 0.83 8.4 9.1 1 8.2 9.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 ETO01203.1 - 0.85 8.3 17.0 1.2 7.9 17.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 ETO01203.1 - 1.1 8.2 13.1 1.5 7.8 13.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 ETO01203.1 - 1.2 8.0 7.5 1.5 7.7 7.5 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF3807 PF12720.7 ETO01203.1 - 1.4 9.1 20.7 0.051 13.8 14.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) CDC45 PF02724.14 ETO01203.1 - 1.5 7.0 14.9 1.9 6.7 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3682 PF12446.8 ETO01203.1 - 1.7 9.1 22.4 3.8 8.0 22.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Band_3_cyto PF07565.13 ETO01203.1 - 1.9 8.2 8.9 2.8 7.7 8.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Otopetrin PF03189.13 ETO01203.1 - 2 7.2 4.7 2.6 6.8 4.7 1.1 1 0 0 1 1 1 0 Otopetrin Ureide_permease PF07168.11 ETO01203.1 - 2.6 6.7 8.0 3.4 6.3 8.0 1.2 1 0 0 1 1 1 0 Ureide permease Membralin PF09746.9 ETO01203.1 - 2.8 6.9 6.2 3.4 6.6 6.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein RR_TM4-6 PF06459.12 ETO01203.1 - 6.9 6.4 20.0 11 5.7 20.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 ETO01203.1 - 7.7 6.3 22.2 8.3 6.2 21.0 1.7 1 1 1 2 2 2 0 Pox virus Ag35 surface protein Geminin PF07412.12 ETO01204.1 - 0.015 15.1 5.1 0.015 15.1 5.1 3.1 2 1 1 3 3 3 0 Geminin Rootletin PF15035.6 ETO01204.1 - 0.024 14.7 9.0 0.024 14.7 9.0 2.2 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Hemocyanin_C PF03723.14 ETO01204.1 - 0.031 13.6 9.1 0.042 13.2 9.1 1.2 1 0 0 1 1 1 0 Hemocyanin, ig-like domain HlyD_2 PF12700.7 ETO01204.1 - 0.14 10.8 25.1 0.19 10.4 25.1 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Fez1 PF06818.15 ETO01204.1 - 0.15 12.5 22.7 0.11 13.0 21.0 1.6 1 1 0 1 1 1 0 Fez1 DUF2808 PF10989.8 ETO01204.1 - 0.17 11.8 7.3 0.15 12.0 6.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2808) TPR_MLP1_2 PF07926.12 ETO01204.1 - 0.2 11.8 26.4 1.4 9.0 13.6 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein TMEM237 PF15383.6 ETO01204.1 - 0.34 10.0 8.0 0.45 9.6 8.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 237 Macoilin PF09726.9 ETO01204.1 - 0.5 8.9 20.8 0.55 8.7 20.8 1.0 1 0 0 1 1 1 0 Macoilin family DUF4200 PF13863.6 ETO01204.1 - 0.54 10.7 31.1 3.5 8.0 8.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) GCD14 PF08704.10 ETO01204.1 - 0.64 9.6 8.4 0.79 9.4 8.4 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit DUF641 PF04859.12 ETO01204.1 - 1.3 9.4 20.9 1.2 9.4 6.5 2.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) HOOK PF05622.12 ETO01204.1 - 1.4 7.0 27.1 1.6 6.8 27.1 1.0 1 0 0 1 1 1 0 HOOK protein DDHD PF02862.17 ETO01204.1 - 1.7 8.8 9.2 1.9 8.6 9.2 1.1 1 0 0 1 1 1 0 DDHD domain TMPIT PF07851.13 ETO01204.1 - 3.2 6.9 16.8 4 6.6 16.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein HMMR_N PF15905.5 ETO01204.1 - 3.6 7.0 30.1 5.9 6.3 30.1 1.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Golgin_A5 PF09787.9 ETO01204.1 - 8.4 5.8 28.1 28 4.0 28.1 1.7 1 1 0 1 1 1 0 Golgin subfamily A member 5 eRF1_1 PF03463.15 ETO01205.1 - 5.7e-09 36.0 0.2 8.4e-09 35.5 0.2 1.2 1 0 0 1 1 1 1 eRF1 domain 1 Mito_carr PF00153.27 ETO01206.1 - 1.3e-42 143.6 0.2 7.1e-14 51.5 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein MatE PF01554.18 ETO01207.1 - 0.043 13.5 0.8 0.054 13.1 0.8 1.1 1 0 0 1 1 1 0 MatE zf-TRAF PF02176.18 ETO01208.1 - 0.0002 22.0 4.8 0.0002 22.0 4.8 2.6 3 1 0 3 3 3 1 TRAF-type zinc finger Cyto_heme_lyase PF01265.17 ETO01208.1 - 0.013 15.1 2.2 0.018 14.7 2.2 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase WD40 PF00400.32 ETO01212.1 - 4.4e-06 27.3 0.4 9.4e-06 26.3 0.4 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat Ank_4 PF13637.6 ETO01213.1 - 0.0029 18.1 0.2 0.013 16.1 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO01213.1 - 0.027 15.0 0.8 1.6 9.5 0.0 3.4 4 0 0 4 4 4 0 Ankyrin repeat Ank_2 PF12796.7 ETO01213.1 - 0.073 13.7 0.3 0.15 12.7 0.3 1.8 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Tat PF00539.18 ETO01215.1 - 0.044 13.9 4.0 0.051 13.7 0.1 2.5 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) RecR PF02132.15 ETO01215.1 - 0.13 11.9 1.5 0.33 10.6 0.1 2.5 3 0 0 3 3 3 0 RecR protein Kelch_1 PF01344.25 ETO01217.1 - 0.12 12.0 0.1 53 3.5 0.0 3.4 3 0 0 3 3 3 0 Kelch motif SAM_4 PF18017.1 ETO01220.1 - 0.11 12.5 0.1 0.29 11.1 0.1 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF5409 PF17421.2 ETO01220.1 - 0.25 12.1 6.4 0.1 13.3 0.5 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5409) WD40 PF00400.32 ETO01221.1 - 1.6e-06 28.7 0.0 2.2e-05 25.1 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Atg14 PF10186.9 ETO01222.1 - 0.0023 17.1 8.2 0.0025 17.0 8.2 1.0 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 ETO01222.1 - 0.0027 17.7 4.7 0.0033 17.4 4.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Med3 PF11593.8 ETO01222.1 - 0.012 14.9 5.7 0.013 14.7 5.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Phlebovirus_NSM PF07246.11 ETO01222.1 - 0.025 14.0 3.8 0.032 13.6 3.8 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M HAP1_N PF04849.13 ETO01222.1 - 0.057 12.6 14.6 0.082 12.1 14.6 1.4 1 1 0 1 1 1 0 HAP1 N-terminal conserved region AAA_13 PF13166.6 ETO01222.1 - 0.063 11.9 7.8 0.065 11.9 7.8 1.0 1 0 0 1 1 1 0 AAA domain CorA PF01544.18 ETO01222.1 - 0.068 12.5 5.5 0.082 12.2 5.5 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3450 PF11932.8 ETO01222.1 - 0.071 12.4 14.3 0.082 12.2 14.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Mito_fiss_reg PF05308.11 ETO01222.1 - 0.11 12.6 8.3 0.12 12.4 8.3 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator UPF0515 PF15135.6 ETO01222.1 - 0.19 11.1 7.0 0.22 10.9 7.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 DUF2203 PF09969.9 ETO01222.1 - 0.24 12.1 5.4 0.3 11.8 5.4 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Suf PF05843.14 ETO01222.1 - 0.31 11.0 7.6 0.35 10.8 7.6 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF935 PF06074.12 ETO01222.1 - 0.42 9.3 8.9 0.48 9.1 8.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF935) DUF3573 PF12097.8 ETO01222.1 - 0.5 9.1 4.8 0.5 9.1 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) RRN3 PF05327.11 ETO01222.1 - 0.9 8.0 11.2 1.1 7.8 11.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4407 PF14362.6 ETO01222.1 - 1.1 8.6 9.2 1.2 8.5 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) OATP PF03137.20 ETO01222.1 - 1.2 7.3 2.5 1.2 7.3 2.5 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CLN3 PF02487.17 ETO01222.1 - 1.2 8.0 4.2 1.5 7.8 4.2 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4094 PF13334.6 ETO01222.1 - 1.5 9.3 8.5 0.39 11.2 5.8 1.4 2 0 0 2 2 1 0 Domain of unknown function (DUF4094) DUF3464 PF11947.8 ETO01222.1 - 9.8 5.9 6.7 15 5.4 6.7 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 WD40 PF00400.32 ETO01224.1 - 1.1e-14 54.5 13.5 0.00034 21.4 0.2 5.7 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01224.1 - 9.5e-08 32.2 0.4 0.065 13.5 0.0 4.0 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01224.1 - 0.0011 17.7 2.9 0.74 8.4 0.1 3.5 3 1 1 4 4 4 2 Nucleoporin Nup120/160 RasGEF_N PF00618.20 ETO01225.1 - 0.057 13.7 3.8 0.15 12.3 3.8 1.8 1 1 0 1 1 1 0 RasGEF N-terminal motif RelA_SpoT PF04607.17 ETO01227.1 - 0.029 14.6 0.3 0.073 13.4 0.3 1.6 1 0 0 1 1 1 0 Region found in RelA / SpoT proteins zf-Mss51 PF13824.6 ETO01227.1 - 0.042 13.9 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 DNA_ligase_ZBD PF03119.16 ETO01227.1 - 0.24 11.4 2.7 4.7 7.3 0.3 2.4 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain MSA_2 PF00985.17 ETO01228.1 - 0.085 13.2 1.6 0.12 12.8 1.6 1.1 1 0 0 1 1 1 0 Merozoite Surface Antigen 2 (MSA-2) family SDA1 PF05285.12 ETO01230.1 - 4.4 6.6 58.4 5.5 6.3 58.4 1.2 1 0 0 1 1 1 0 SDA1 ubiquitin PF00240.23 ETO01231.1 - 3e-58 193.5 3.4 6.5e-34 115.5 0.4 2.0 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETO01231.1 - 5.2e-28 96.7 2.1 6e-17 61.3 0.5 2.0 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO01231.1 - 1.5e-10 41.4 0.9 2.9e-05 24.4 0.1 3.3 2 2 0 2 2 2 2 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO01231.1 - 1.1e-07 31.9 0.1 0.0046 17.0 0.1 2.5 2 1 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO01231.1 - 2.5e-07 30.9 0.3 0.0064 16.8 0.1 2.1 1 1 1 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO01231.1 - 3.2e-07 30.2 0.4 0.0015 18.4 0.1 2.2 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ETO01231.1 - 1.5e-05 25.5 0.1 0.04 14.5 0.0 2.2 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO01231.1 - 0.0001 22.3 2.4 3.1 7.9 0.2 3.1 2 1 1 3 3 3 3 Ubiquitin-like domain DUF2870 PF11069.8 ETO01231.1 - 0.0043 17.4 0.2 7.9 6.9 0.0 3.0 2 2 2 4 4 4 2 Protein of unknown function (DUF2870) Sde2_N_Ubi PF13019.6 ETO01231.1 - 0.032 14.1 0.0 0.54 10.1 0.0 2.0 2 0 0 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain DUF969 PF06149.12 ETO01231.1 - 0.037 13.4 0.0 6.9 6.0 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF969) FERM_f0 PF16511.5 ETO01231.1 - 0.084 13.2 0.7 20 5.6 0.2 3.0 2 1 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM DUF5383 PF17355.2 ETO01231.1 - 0.14 12.6 0.9 8.9 6.7 0.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5383) NINJA_B PF16136.5 ETO01235.1 - 0.04 14.3 1.2 0.048 14.0 1.2 1.3 1 0 0 1 1 1 0 Putative nuclear localisation signal DUF1924 PF09086.11 ETO01237.1 - 0.092 13.1 1.1 0.19 12.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1924) DUF1911 PF08929.10 ETO01238.1 - 0.029 15.2 1.9 0.042 14.6 1.7 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1911) Scm3 PF10384.9 ETO01238.1 - 0.06 13.1 0.6 0.13 12.0 0.6 1.6 1 0 0 1 1 1 0 Centromere protein Scm3 GT-D PF08759.11 ETO01238.1 - 0.067 12.9 3.8 0.078 12.6 1.9 1.7 1 1 1 2 2 2 0 Glycosyltransferase GT-D fold Cytochrom_C PF00034.21 ETO01238.1 - 0.19 12.9 0.0 23 6.2 0.0 2.4 2 0 0 2 2 2 0 Cytochrome c Spore_Cse60 PF10957.8 ETO01238.1 - 0.82 9.7 8.8 2 8.5 0.2 2.9 2 1 0 3 3 3 0 Sporulation protein Cse60 BLYB PF05289.11 ETO01239.1 - 0.0021 18.3 1.6 0.0026 18.0 1.6 1.2 1 0 0 1 1 1 1 Borrelia hemolysin accessory protein FPRL1_inhibitor PF16104.5 ETO01239.1 - 0.018 15.2 0.6 0.029 14.5 0.6 1.4 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein Imm41 PF15592.6 ETO01239.1 - 0.11 12.8 0.2 0.19 12.0 0.2 1.6 1 1 0 1 1 1 0 Immunity protein 41 zf-C3HC4_2 PF13923.6 ETO01240.1 - 0.57 10.1 8.5 1.3 8.9 5.8 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) U-box PF04564.15 ETO01248.1 - 2.7e-13 49.9 0.1 5.4e-13 48.9 0.1 1.5 1 1 0 1 1 1 1 U-box domain WD40 PF00400.32 ETO01250.1 - 2.4e-26 91.4 4.2 3.7e-06 27.6 0.0 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01250.1 - 1.1e-14 54.4 0.0 0.00018 21.7 0.0 4.1 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01250.1 - 2.5e-08 33.6 1.1 0.0013 18.1 0.1 2.6 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO01250.1 - 2.2e-05 24.5 0.1 0.39 10.6 0.0 2.9 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ETO01250.1 - 3.1e-05 23.2 0.1 0.048 12.7 0.0 2.4 1 1 2 3 3 3 3 Coatomer WD associated region Ge1_WD40 PF16529.5 ETO01250.1 - 9.1e-05 21.6 0.1 3.4 6.6 0.0 3.2 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 ETO01250.1 - 0.00014 21.5 0.0 0.00071 19.2 0.0 1.8 2 0 0 2 2 2 1 PQQ-like domain Cytochrom_D1 PF02239.16 ETO01250.1 - 0.00056 18.6 0.0 0.0017 17.0 0.0 1.6 1 1 1 2 2 2 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO01250.1 - 0.0026 17.6 0.0 5 7.2 0.0 2.9 3 0 0 3 3 3 2 PQQ enzyme repeat PTB PF08416.13 ETO01250.1 - 0.0073 16.5 0.0 0.41 10.8 0.1 2.7 2 1 1 3 3 3 1 Phosphotyrosine-binding domain PD40 PF07676.12 ETO01250.1 - 0.0098 15.8 0.1 13 5.9 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat SBD PF17882.1 ETO01250.1 - 0.019 14.8 0.0 0.29 11.0 0.0 2.2 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain Lactonase PF10282.9 ETO01250.1 - 0.034 13.4 0.0 0.093 12.0 0.0 1.7 1 1 0 1 1 1 0 Lactonase, 7-bladed beta-propeller Frtz PF11768.8 ETO01250.1 - 0.042 12.2 0.1 1.6 6.9 0.0 2.2 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz TFIIIC_delta PF12657.7 ETO01250.1 - 0.056 13.4 0.0 6.2 6.7 0.0 2.3 1 1 1 2 2 2 0 Transcription factor IIIC subunit delta N-term DPPIV_N PF00930.21 ETO01250.1 - 0.1 11.3 0.0 2.9 6.6 0.0 2.4 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF3139 PF11337.8 ETO01251.1 - 1.5 9.5 11.4 6.9 7.4 0.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) KicB PF03882.14 ETO01253.1 - 0.021 15.0 1.7 0.2 11.9 0.4 2.5 1 1 2 3 3 3 0 MukF winged-helix domain Pox_A_type_inc PF04508.12 ETO01253.1 - 0.098 12.5 1.1 50 4.0 0.0 3.6 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat CENP-R PF06729.12 ETO01255.1 - 0.012 15.5 1.2 0.014 15.3 1.2 1.1 1 0 0 1 1 1 0 Kinetochore component, CENP-R Kelch_4 PF13418.6 ETO01256.1 - 0.00055 19.9 3.6 0.0033 17.4 0.2 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01256.1 - 0.00066 19.2 2.2 0.9 9.2 0.3 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO01256.1 - 0.00088 19.2 6.1 2.2 8.4 0.6 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO01256.1 - 0.0021 18.0 6.0 0.77 9.8 0.4 4.4 5 0 0 5 5 5 2 Kelch motif WD40 PF00400.32 ETO01258.1 - 1.2e-23 82.9 19.6 2.8e-07 31.1 0.4 5.5 6 2 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01258.1 - 3.5e-10 40.1 0.3 0.00068 19.9 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01258.1 - 1.4e-06 27.3 4.2 0.026 13.2 0.3 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO01258.1 - 0.00044 19.7 4.1 0.42 9.9 0.2 3.4 1 1 3 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETO01258.1 - 0.0019 18.1 2.7 5.1 6.9 0.3 3.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A SAM_decarbox PF01536.16 ETO01259.1 - 0.0065 15.5 1.1 0.0085 15.1 1.1 1.1 1 0 0 1 1 1 1 Adenosylmethionine decarboxylase DUF1737 PF08410.10 ETO01259.1 - 0.014 15.2 0.0 0.038 13.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1737) AAA_31 PF13614.6 ETO01260.1 - 1.1e-28 100.3 0.4 1.7e-28 99.7 0.4 1.2 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ETO01260.1 - 1.1e-09 38.4 0.0 1.5e-09 38.0 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ETO01260.1 - 1.5e-05 24.6 0.0 2.2e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 ETO01260.1 - 0.00011 21.5 0.2 0.0014 17.9 0.1 2.5 2 1 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 ETO01260.1 - 0.002 17.6 0.1 0.051 13.0 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family MipZ PF09140.11 ETO01260.1 - 0.021 14.1 0.0 5.2 6.3 0.0 2.2 1 1 1 2 2 2 0 ATPase MipZ DnaJ PF00226.31 ETO01261.1 - 0.18 12.0 0.5 0.33 11.1 0.1 1.6 2 0 0 2 2 2 0 DnaJ domain BrnA_antitoxin PF14384.6 ETO01262.1 - 0.055 14.0 2.4 0.51 10.9 1.3 2.3 2 0 0 2 2 2 0 BrnA antitoxin of type II toxin-antitoxin system DUF3292 PF11696.8 ETO01262.1 - 0.13 10.6 4.8 0.14 10.5 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3504 PF12012.8 ETO01262.1 - 0.16 11.9 4.6 0.24 11.3 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) SDA1 PF05285.12 ETO01262.1 - 0.17 11.3 19.3 0.25 10.7 19.3 1.3 1 1 0 1 1 1 0 SDA1 Ndc1_Nup PF09531.10 ETO01262.1 - 0.37 9.4 1.3 0.44 9.2 1.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Atrophin-1 PF03154.15 ETO01262.1 - 0.54 8.5 10.0 0.73 8.1 10.0 1.2 1 0 0 1 1 1 0 Atrophin-1 family Cellulose_synt PF03552.14 ETO01262.1 - 1.3 7.5 5.6 1.3 7.4 5.6 1.0 1 0 0 1 1 1 0 Cellulose synthase Connexin PF00029.19 ETO01262.1 - 3.8 7.2 6.8 5 6.8 6.8 1.2 1 0 0 1 1 1 0 Connexin Ac110_PIF PF07280.11 ETO01263.1 - 0.058 13.2 1.6 7.6 6.4 0.2 2.5 2 0 0 2 2 2 0 Per os infectivity factor AC110 NACHT PF05729.12 ETO01264.1 - 0.0097 15.8 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NAM PF02365.15 ETO01264.1 - 3.3 8.7 7.0 6.2 7.7 1.4 2.5 2 1 0 2 2 2 0 No apical meristem (NAM) protein Cys_rich_VLP PF14194.6 ETO01265.1 - 0.035 14.2 0.2 0.067 13.3 0.2 1.5 1 0 0 1 1 1 0 Cysteine-rich VLP TLD PF07534.16 ETO01266.1 - 0.00014 22.1 0.2 0.0017 18.6 0.0 2.3 2 1 0 2 2 2 1 TLD DUF4240 PF14024.6 ETO01266.1 - 0.15 12.2 0.0 0.23 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4240) WD40 PF00400.32 ETO01268.1 - 2.8e-11 43.8 5.7 1.1e-07 32.4 0.8 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01268.1 - 0.0015 17.2 0.5 0.0026 16.5 0.2 1.4 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01268.1 - 0.002 18.4 0.0 0.0043 17.3 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01268.1 - 0.007 15.7 0.5 0.007 15.7 0.5 2.1 2 0 0 2 2 2 1 WD40-like domain PB1 PF00564.24 ETO01270.1 - 0.013 15.4 0.7 0.051 13.5 0.4 2.0 2 0 0 2 2 2 0 PB1 domain DUF3164 PF11363.8 ETO01270.1 - 0.019 14.5 0.4 0.072 12.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3164) UN_NPL4 PF11543.8 ETO01270.1 - 0.028 14.9 0.0 0.068 13.7 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 AAA_assoc_C PF09821.9 ETO01271.1 - 0.081 13.5 0.3 0.13 12.8 0.3 1.4 1 0 0 1 1 1 0 C-terminal AAA-associated domain PHR PF08005.12 ETO01272.1 - 0.0049 17.5 0.1 0.0072 17.0 0.1 1.3 1 0 0 1 1 1 1 PHR domain AAA_12 PF13087.6 ETO01273.1 - 2.2e-45 154.7 1.9 3.4e-45 154.1 1.9 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETO01273.1 - 2e-12 47.5 1.1 1.7e-11 44.4 0.0 2.6 2 2 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ETO01273.1 - 0.00016 21.5 0.2 0.045 13.5 0.0 2.7 3 0 0 3 3 3 2 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 ETO01273.1 - 0.00047 19.9 0.0 0.0012 18.6 0.0 1.7 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C PF13361.6 ETO01273.1 - 0.011 15.2 1.4 0.1 11.9 0.1 2.5 1 1 1 2 2 2 0 UvrD-like helicase C-terminal domain Melibiase PF02065.18 ETO01273.1 - 0.03 13.3 0.1 0.057 12.4 0.1 1.4 1 0 0 1 1 1 0 Melibiase AAA_30 PF13604.6 ETO01273.1 - 0.068 12.9 0.0 0.2 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain Sin_N PF04801.13 ETO01274.1 - 0.074 12.3 0.2 0.085 12.1 0.2 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region WD40 PF00400.32 ETO01275.1 - 1.1e-18 67.2 19.3 4.8e-07 30.4 1.3 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO01275.1 - 3.8e-08 32.4 3.3 0.0011 17.7 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01275.1 - 1.1e-07 32.1 0.5 0.0076 16.5 0.0 2.9 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01275.1 - 0.0018 17.7 1.0 0.068 12.5 0.5 2.3 1 1 0 2 2 2 2 WD40-like domain NACHT PF05729.12 ETO01276.1 - 0.011 15.6 0.0 0.012 15.5 0.0 1.2 1 0 0 1 1 1 0 NACHT domain DUF3715 PF12509.8 ETO01279.1 - 0.047 13.7 1.9 0.095 12.7 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3715) S_2TMBeta PF18153.1 ETO01279.1 - 0.055 13.3 1.2 0.12 12.2 1.2 1.5 1 0 0 1 1 1 0 SMODS-associating 2TM, beta-strand rich effector domain BSP_II PF05432.11 ETO01280.1 - 0.0043 16.8 12.8 0.0043 16.8 12.8 3.5 3 0 0 3 3 3 2 Bone sialoprotein II (BSP-II) DUF2052 PF09747.9 ETO01280.1 - 0.84 9.7 41.8 0.14 12.3 12.9 4.1 4 0 0 4 4 4 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO01280.1 - 1.5 7.0 37.8 0.053 11.8 9.0 3.3 3 0 0 3 3 3 0 CDC45-like protein Myc_N PF01056.18 ETO01280.1 - 2.4 8.0 33.0 0.27 11.1 7.1 3.7 3 0 0 3 3 3 0 Myc amino-terminal region DUF2076 PF09849.9 ETO01283.1 - 0.088 12.8 6.1 0.15 12.0 6.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Presenilin PF01080.17 ETO01283.1 - 1.5 7.5 10.1 3 6.5 10.1 1.4 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 ETO01283.1 - 8 6.7 9.4 15 5.8 9.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) PI3_PI4_kinase PF00454.27 ETO01285.1 - 4.1e-37 128.3 2.0 5e-35 121.5 0.0 3.3 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase FRB_dom PF08771.11 ETO01285.1 - 0.0011 19.4 6.8 0.38 11.2 0.2 4.3 4 0 0 4 4 4 2 FKBP12-rapamycin binding domain FATC PF02260.20 ETO01286.1 - 2e-09 37.1 0.1 4.1e-09 36.1 0.1 1.5 1 0 0 1 1 1 1 FATC domain DNA_pol_phi PF04931.13 ETO01286.1 - 1.8 6.6 7.0 2.2 6.3 7.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 ETO01286.1 - 2.2 8.7 7.6 4.5 7.7 7.6 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal IL1_propep PF02394.16 ETO01286.1 - 7.1 7.6 7.4 3.9 8.4 0.1 2.5 1 1 2 3 3 3 0 Interleukin-1 propeptide Mustang PF15682.5 ETO01287.1 - 0.032 14.3 0.0 0.076 13.1 0.0 1.6 1 0 0 1 1 1 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 DnaJ PF00226.31 ETO01288.1 - 2.8e-21 75.4 1.6 5.7e-21 74.4 1.6 1.6 1 0 0 1 1 1 1 DnaJ domain T4_deiodinase PF00837.17 ETO01289.1 - 3.2e-17 62.6 0.0 6e-17 61.7 0.0 1.3 1 0 0 1 1 1 1 Iodothyronine deiodinase WD40 PF00400.32 ETO01290.1 - 0.015 16.1 3.6 0.073 14.0 2.3 2.4 2 1 0 2 2 2 0 WD domain, G-beta repeat Xpo1 PF08389.12 ETO01292.1 - 0.0018 18.3 0.2 2.7 8.1 0.0 3.6 2 1 1 3 3 3 2 Exportin 1-like protein HEAT_2 PF13646.6 ETO01292.1 - 0.0074 16.7 0.0 0.56 10.6 0.0 2.8 2 1 1 3 3 3 2 HEAT repeats HEAT PF02985.22 ETO01292.1 - 0.1 12.9 0.9 10 6.7 0.0 4.2 5 0 0 5 5 5 0 HEAT repeat DUSP PF06337.12 ETO01292.1 - 0.19 12.3 0.8 0.43 11.2 0.2 1.9 2 0 0 2 2 2 0 DUSP domain WD40 PF00400.32 ETO01293.1 - 1.8e-16 60.2 0.7 1.1e-06 29.3 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01293.1 - 3.5e-07 30.4 0.1 0.00033 20.9 0.0 2.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01293.1 - 2.1e-05 24.0 0.0 3.3e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 WD40-like domain HisK_sensor PF18698.1 ETO01293.1 - 0.027 14.8 0.6 0.047 14.1 0.6 1.5 1 0 0 1 1 1 0 Histidine kinase sensor domain RVT_1 PF00078.27 ETO01297.1 - 4.9e-43 147.2 0.2 9.8e-43 146.2 0.2 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5320 PF17253.2 ETO01299.1 - 0.73 10.9 2.4 1.1 10.4 0.1 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5320) FANCI_S4 PF14678.6 ETO01301.1 - 0.0092 15.1 0.3 0.01 15.0 0.3 1.1 1 0 0 1 1 1 1 FANCI solenoid 4 Menin PF05053.13 ETO01301.1 - 0.038 12.4 6.0 0.038 12.4 6.0 1.0 1 0 0 1 1 1 0 Menin DUF600 PF04634.12 ETO01302.1 - 0.084 12.9 3.2 0.79 9.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function, DUF600 Pro-rich PF15240.6 ETO01302.1 - 0.24 11.6 0.6 0.33 11.2 0.6 1.1 1 0 0 1 1 1 0 Proline-rich CAP_GLY PF01302.25 ETO01303.1 - 0.0057 16.6 0.6 2.5 8.2 0.0 2.3 2 1 0 2 2 2 2 CAP-Gly domain DUF4662 PF15578.6 ETO01306.1 - 0.0078 16.0 2.9 0.0078 16.0 2.9 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4662) Med19 PF10278.9 ETO01306.1 - 0.01 15.8 12.3 0.01 15.8 12.3 4.5 5 0 0 5 5 5 0 Mediator of RNA pol II transcription subunit 19 YL1 PF05764.13 ETO01306.1 - 4.3 7.4 36.2 0.021 15.0 15.4 2.7 2 1 0 2 2 2 0 YL1 nuclear protein Skp1_POZ PF03931.15 ETO01307.1 - 0.12 12.6 0.1 0.17 12.1 0.1 1.2 1 0 0 1 1 1 0 Skp1 family, tetramerisation domain Ufm1 PF03671.14 ETO01308.1 - 0.07 13.2 0.1 0.1 12.7 0.1 1.5 1 1 0 1 1 1 0 Ubiquitin fold modifier 1 protein HEAT_2 PF13646.6 ETO01309.1 - 4.6e-10 39.7 0.2 0.083 13.3 0.1 4.4 2 1 3 5 5 5 3 HEAT repeats RTP1_C1 PF10363.9 ETO01309.1 - 0.00045 20.4 5.9 0.001 19.2 0.1 3.7 3 1 1 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Lyase_N PF09092.11 ETO01309.1 - 0.044 13.6 0.0 0.1 12.4 0.0 1.6 1 0 0 1 1 1 0 Lyase, N terminal DUF4093 PF13331.6 ETO01311.1 - 0.0058 17.0 0.2 0.021 15.3 0.2 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4093) WD40 PF00400.32 ETO01313.1 - 2.8e-27 94.4 17.9 1.4e-06 28.9 1.2 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01313.1 - 5.5e-11 42.6 0.4 0.002 18.4 0.0 3.9 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01313.1 - 2.9e-08 32.8 1.6 0.37 9.4 0.0 4.2 1 1 2 4 4 4 4 Nucleoporin Nup120/160 DUF659 PF04937.15 ETO01313.1 - 0.011 15.6 0.3 0.019 14.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF 659) PTP_tm PF18861.1 ETO01314.1 - 0.19 11.7 0.3 0.71 9.8 0.3 1.8 1 1 0 1 1 1 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J Ion_trans PF00520.31 ETO01315.1 - 2.8e-11 43.1 5.0 3.8e-11 42.7 5.0 1.1 1 0 0 1 1 1 1 Ion transport protein WD40 PF00400.32 ETO01316.1 - 5.7e-32 109.2 22.8 1.2e-06 29.1 0.4 6.9 5 2 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01316.1 - 1.8e-07 31.4 1.4 0.068 13.5 0.0 4.8 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_1 PF01344.25 ETO01317.1 - 2.6e-06 26.9 0.7 0.0013 18.3 0.1 3.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO01317.1 - 0.00023 21.3 3.2 6.4 7.2 0.0 4.4 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO01317.1 - 0.00039 20.4 0.1 0.0045 17.0 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01317.1 - 0.0021 18.0 5.5 3.6 7.7 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO01317.1 - 0.01 15.8 2.2 3.3 7.8 0.1 3.7 4 0 0 4 4 4 0 Kelch motif TIP120 PF08623.10 ETO01319.1 - 0.087 12.6 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) Peptidase_M22 PF00814.25 ETO01319.1 - 0.098 12.3 0.0 0.13 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycoprotease family Actin PF00022.19 ETO01320.1 - 7.3e-24 84.1 0.0 8.1e-24 84.0 0.0 1.0 1 0 0 1 1 1 1 Actin Jnk-SapK_ap_N PF09744.9 ETO01321.1 - 0.026 14.8 16.5 0.029 14.6 16.5 1.0 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 EF1_GNE PF00736.19 ETO01321.1 - 0.036 14.3 2.7 0.047 13.9 2.7 1.3 1 0 0 1 1 1 0 EF-1 guanine nucleotide exchange domain LRS4 PF10422.9 ETO01321.1 - 0.12 12.0 11.2 0.14 11.7 11.2 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 Uds1 PF15456.6 ETO01321.1 - 0.19 11.9 6.7 0.19 11.9 4.7 1.7 1 1 1 2 2 2 0 Up-regulated During Septation Fib_alpha PF08702.10 ETO01321.1 - 0.45 10.7 15.2 0.53 10.5 15.2 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family UPF0242 PF06785.11 ETO01321.1 - 0.71 9.9 21.2 1.7 8.7 21.2 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ZapB PF06005.12 ETO01321.1 - 1.3 9.5 17.1 2.4 8.6 0.2 2.3 1 1 1 2 2 2 0 Cell division protein ZapB Csm1_N PF18504.1 ETO01321.1 - 1.6 9.1 16.8 0.97 9.8 10.1 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain PepSY_like PF11396.8 ETO01321.1 - 1.7 9.3 9.8 0.49 11.0 2.0 2.1 1 1 1 2 2 2 0 Putative beta-lactamase-inhibitor-like, PepSY-like SieB PF14163.6 ETO01321.1 - 1.7 8.1 8.2 0.073 12.6 1.7 1.9 1 1 1 2 2 2 0 Super-infection exclusion protein B YabA PF06156.13 ETO01321.1 - 4.3 8.0 13.0 8.3 7.1 13.0 1.6 1 1 0 1 1 1 0 Initiation control protein YabA Exonuc_VII_L PF02601.15 ETO01321.1 - 9.3 5.7 9.9 9.9 5.6 9.9 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nup88 PF10168.9 ETO01322.1 - 0.0053 14.6 0.2 0.0053 14.6 0.2 1.0 1 0 0 1 1 1 1 Nuclear pore component PUB PF09409.10 ETO01323.1 - 9.4e-05 22.3 2.2 0.00015 21.6 0.3 2.2 2 1 0 2 2 2 1 PUB domain N6-adenineMlase PF10237.9 ETO01323.1 - 0.0087 15.9 0.1 0.014 15.2 0.1 1.5 1 1 0 1 1 1 1 Probable N6-adenine methyltransferase PDDEXK_7 PF04411.12 ETO01323.1 - 0.034 14.1 0.2 0.053 13.5 0.1 1.5 1 1 0 1 1 1 0 PD-(D/E)XK nuclease superfamily TAF1_subA PF14929.6 ETO01325.1 - 0.012 15.0 0.4 0.013 14.9 0.4 1.0 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A FrhB_FdhB_C PF04432.13 ETO01325.1 - 0.014 15.3 0.2 0.015 15.1 0.2 1.0 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus DUF5586 PF17824.1 ETO01325.1 - 0.038 13.1 0.0 0.043 12.9 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5586) DUF327 PF03885.13 ETO01327.1 - 0.038 13.9 1.0 0.051 13.5 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF327) Tex_N PF09371.10 ETO01328.1 - 4.4 6.9 9.7 2 8.0 1.5 3.3 3 1 0 3 3 3 0 Tex-like protein N-terminal domain DUF617 PF04759.13 ETO01329.1 - 0.0058 16.7 0.3 0.0077 16.3 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF617 NiFe-hyd_HybE PF11939.8 ETO01329.1 - 0.077 12.9 0.1 0.09 12.7 0.1 1.2 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE Pannexin_like PF12534.8 ETO01329.1 - 0.15 11.2 3.9 0.17 11.0 3.9 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 zf-C3HC4_5 PF17121.5 ETO01330.1 - 0.0094 15.8 6.3 0.0094 15.8 6.3 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF1655 PF07868.11 ETO01330.1 - 0.057 13.5 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1655) TRAP_alpha PF03896.16 ETO01331.1 - 0.12 11.6 1.4 0.13 11.5 1.4 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit ART PF01129.18 ETO01333.1 - 4.4e-06 26.1 0.4 4.4e-06 26.1 0.4 2.0 3 0 0 3 3 3 1 NAD:arginine ADP-ribosyltransferase PUB PF09409.10 ETO01333.1 - 0.0023 17.9 0.1 0.011 15.6 0.1 2.2 1 0 0 1 1 1 1 PUB domain WD40 PF00400.32 ETO01334.1 - 1.4e-06 28.9 3.3 0.0082 17.0 0.3 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01334.1 - 0.019 13.6 0.0 0.48 9.0 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 FAD_binding_8 PF08022.12 ETO01336.1 - 0.053 13.6 0.1 9 6.4 0.0 2.4 2 0 0 2 2 2 0 FAD-binding domain RRM_7 PF16367.5 ETO01336.1 - 0.08 13.1 0.3 0.75 10.0 0.1 2.2 2 0 0 2 2 2 0 RNA recognition motif Ral PF11058.8 ETO01336.1 - 0.12 12.0 1.0 10 5.8 0.0 3.1 3 0 0 3 3 3 0 Antirestriction protein Ral Ammonium_transp PF00909.21 ETO01337.1 - 0.056 12.1 0.1 0.071 11.8 0.1 1.1 1 0 0 1 1 1 0 Ammonium Transporter Family FPL PF09758.9 ETO01339.1 - 0.00029 20.9 1.5 0.15 12.0 0.3 2.3 1 1 1 2 2 2 2 Uncharacterised conserved protein DUF3600 PF12207.8 ETO01339.1 - 0.043 13.8 2.3 1.9 8.4 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3600) DUF982 PF06169.12 ETO01339.1 - 0.11 12.5 0.0 0.7 10.0 0.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF982) PAM2 PF07145.15 ETO01340.1 - 0.00076 19.0 3.7 0.0017 17.9 3.7 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region DUF410 PF04190.13 ETO01341.1 - 0.012 15.4 0.2 0.012 15.4 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF410) Helicase_C PF00271.31 ETO01342.1 - 0.0032 17.8 0.0 0.018 15.4 0.0 2.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain VWA_2 PF13519.6 ETO01342.1 - 0.0088 16.7 0.0 0.047 14.3 0.0 2.2 2 0 0 2 2 2 1 von Willebrand factor type A domain SecA_DEAD PF07517.14 ETO01342.1 - 0.0091 15.3 0.6 0.041 13.2 0.0 2.4 2 0 0 2 2 2 1 SecA DEAD-like domain RsgA_GTPase PF03193.16 ETO01343.1 - 1.7e-05 24.8 0.6 1.7e-05 24.8 0.6 3.9 4 1 0 4 4 4 1 RsgA GTPase Sigma70_ner PF04546.13 ETO01343.1 - 4.3e-05 23.5 9.7 4.3e-05 23.5 9.7 5.8 4 2 1 5 5 4 1 Sigma-70, non-essential region MMR_HSR1 PF01926.23 ETO01343.1 - 0.00012 22.1 0.0 0.00012 22.1 0.0 4.1 5 0 0 5 5 5 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO01343.1 - 0.0072 16.8 0.1 0.0072 16.8 0.1 4.4 5 1 0 5 5 4 1 ABC transporter AAA PF00004.29 ETO01343.1 - 0.0077 16.7 0.2 7.6 7.0 0.1 3.4 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ETO01343.1 - 0.028 14.2 0.1 0.059 13.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 ETO01343.1 - 0.039 14.3 1.4 0.27 11.6 0.1 2.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO01343.1 - 0.075 13.4 0.3 0.5 10.7 0.0 2.6 2 0 0 2 2 2 0 AAA ATPase domain AAA_18 PF13238.6 ETO01343.1 - 0.077 13.5 2.8 2.8 8.5 0.2 4.0 2 0 0 2 2 2 0 AAA domain T2SSE PF00437.20 ETO01343.1 - 0.12 11.4 1.9 0.15 11.1 0.1 2.1 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_22 PF13401.6 ETO01343.1 - 0.16 12.2 3.4 0.55 10.5 0.1 3.7 4 0 0 4 4 4 0 AAA domain Aldo_ket_red PF00248.21 ETO01344.1 - 0.00073 18.8 0.0 0.00093 18.5 0.0 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family ADIP PF11559.8 ETO01345.1 - 1e-05 25.7 13.3 0.00045 20.3 4.9 2.2 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding PI3K_P85_iSH2 PF16454.5 ETO01345.1 - 0.0039 16.8 4.8 0.0039 16.8 4.8 2.2 2 0 0 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ZapB PF06005.12 ETO01345.1 - 0.0039 17.6 10.0 0.0049 17.3 6.6 2.5 2 1 0 2 2 2 1 Cell division protein ZapB Rab5-bind PF09311.11 ETO01345.1 - 0.0073 15.7 6.5 0.01 15.3 6.4 1.3 1 1 0 1 1 1 1 Rabaptin-like protein HALZ PF02183.18 ETO01345.1 - 0.014 15.6 2.1 0.014 15.6 2.1 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper Shugoshin_N PF07558.11 ETO01345.1 - 0.014 15.2 3.3 0.059 13.2 2.4 2.4 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.15 ETO01345.1 - 0.039 14.0 2.3 0.039 14.0 2.3 3.1 3 0 0 3 3 3 0 Basic region leucine zipper Mod_r PF07200.13 ETO01345.1 - 0.066 13.3 9.8 0.088 12.9 8.6 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Atg14 PF10186.9 ETO01345.1 - 0.072 12.2 15.5 0.084 11.9 15.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3606 PF12244.8 ETO01345.1 - 0.088 12.8 0.5 0.23 11.4 0.0 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF3606) KfrA_N PF11740.8 ETO01345.1 - 0.095 13.4 0.1 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DUF4694 PF15765.5 ETO01345.1 - 0.11 12.6 6.5 0.13 12.3 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4694) Histidinol_dh PF00815.20 ETO01345.1 - 0.16 11.0 1.9 0.17 10.8 1.4 1.3 1 1 0 1 1 1 0 Histidinol dehydrogenase DivIC PF04977.15 ETO01345.1 - 0.17 11.7 2.1 0.51 10.1 1.5 2.1 1 1 1 2 2 2 0 Septum formation initiator DUF1387 PF07139.11 ETO01345.1 - 0.23 11.1 17.3 0.28 10.9 17.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4477 PF14780.6 ETO01345.1 - 0.26 10.9 4.8 0.42 10.2 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) ApoO PF09769.9 ETO01345.1 - 0.3 11.1 1.4 1.7 8.6 1.4 2.2 1 1 0 1 1 1 0 Apolipoprotein O Golgin_A5 PF09787.9 ETO01345.1 - 0.31 10.4 13.0 0.38 10.2 13.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Cortex-I_coil PF09304.10 ETO01345.1 - 0.33 11.2 10.0 0.11 12.7 4.8 2.4 1 1 2 3 3 3 0 Cortexillin I, coiled coil APG6_N PF17675.1 ETO01345.1 - 0.33 11.5 12.4 0.16 12.5 10.1 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF3450 PF11932.8 ETO01345.1 - 0.49 9.7 4.6 0.35 10.1 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO01345.1 - 0.49 10.4 3.1 0.4 10.7 1.9 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc24 PF08286.11 ETO01345.1 - 0.66 10.2 8.2 2.2 8.6 7.6 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 JIP_LZII PF16471.5 ETO01345.1 - 0.87 9.8 8.9 0.11 12.7 2.5 2.4 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Tub_N PF16322.5 ETO01345.1 - 0.88 9.9 13.2 1.3 9.4 13.2 1.2 1 0 0 1 1 1 0 Tubby N-terminal TMPIT PF07851.13 ETO01345.1 - 4.8 6.3 9.9 5.5 6.1 9.9 1.3 1 0 0 1 1 1 0 TMPIT-like protein ATG16 PF08614.11 ETO01345.1 - 5.9 7.1 15.9 0.23 11.7 8.6 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF848 PF05852.11 ETO01345.1 - 8.4 6.5 11.9 1.6 8.8 3.2 2.6 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Pox_E10 PF04805.12 ETO01347.1 - 0.011 15.6 0.4 0.24 11.3 0.0 2.7 2 0 0 2 2 2 0 E10-like protein conserved region AAA_9 PF12781.7 ETO01347.1 - 0.019 14.1 0.0 0.057 12.5 0.0 1.8 1 0 0 1 1 1 0 ATP-binding dynein motor region AAA_22 PF13401.6 ETO01347.1 - 0.034 14.4 0.0 0.12 12.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain LAGLIDADG_1 PF00961.19 ETO01347.1 - 0.087 13.8 4.8 0.13 13.2 0.2 2.9 3 0 0 3 3 3 0 LAGLIDADG endonuclease DUF4295 PF14128.6 ETO01348.1 - 0.037 13.9 0.3 0.077 12.8 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4295) Serinc PF03348.15 ETO01349.1 - 0.0033 16.4 1.1 0.0061 15.5 1.1 1.4 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF4611 PF15387.6 ETO01349.1 - 0.21 11.8 12.0 0.42 10.9 8.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Usp PF00582.26 ETO01349.1 - 2.3 8.7 4.9 0.94 10.0 2.3 1.6 2 0 0 2 2 2 0 Universal stress protein family FAM176 PF14851.6 ETO01349.1 - 2.4 7.8 9.8 0.17 11.6 4.1 1.9 2 0 0 2 2 2 0 FAM176 family Flavodoxin_1 PF00258.25 ETO01351.1 - 1.2e-36 126.1 6.5 1.2e-36 126.0 2.6 2.4 2 0 0 2 2 2 1 Flavodoxin FAD_binding_1 PF00667.20 ETO01351.1 - 5.8e-28 98.0 0.0 1.1e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain NAD_binding_1 PF00175.21 ETO01351.1 - 1.2e-15 58.0 0.0 5.6e-15 55.9 0.0 2.2 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETO01351.1 - 0.04 14.0 0.4 3.2 7.8 0.0 2.9 3 0 0 3 3 3 0 Ferric reductase NAD binding domain DUF5071 PF16804.5 ETO01351.1 - 0.21 11.9 2.1 0.31 11.3 0.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5071) CENP-B_dimeris PF09026.10 ETO01351.1 - 0.3 11.5 3.0 0.52 10.7 0.8 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain NACHT PF05729.12 ETO01353.1 - 0.00061 19.8 0.1 0.0009 19.2 0.1 1.3 1 1 0 1 1 1 1 NACHT domain WD40_3 PF15911.5 ETO01356.1 - 0.11 12.5 0.8 2.2 8.3 0.0 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat Kelch_6 PF13964.6 ETO01357.1 - 0.0049 17.1 0.2 0.019 15.3 0.1 2.0 2 1 0 2 2 2 1 Kelch motif WD40 PF00400.32 ETO01358.1 - 4.7e-61 201.3 28.3 1.5e-09 38.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO01358.1 - 2.8e-18 66.0 2.3 0.067 12.1 0.0 6.8 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO01358.1 - 3e-17 62.7 2.9 0.045 14.1 0.0 5.6 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO01358.1 - 1.3e-11 44.7 0.1 0.0016 18.4 0.0 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO01358.1 - 4.4e-09 36.1 0.1 6.9e-05 22.3 0.0 2.7 1 1 1 3 3 3 2 WD40-like domain Arena_nucleocap PF00843.17 ETO01358.1 - 0.004 16.1 0.3 1.4 7.8 0.0 2.4 3 0 0 3 3 3 2 Arenavirus nucleocapsid N-terminal domain Cytochrom_D1 PF02239.16 ETO01358.1 - 0.0078 14.8 1.1 0.62 8.5 0.0 3.0 1 1 2 3 3 3 1 Cytochrome D1 heme domain CHAP PF05257.16 ETO01358.1 - 0.0095 16.5 2.3 6.3 7.5 0.2 4.4 2 2 2 5 5 5 1 CHAP domain NHL PF01436.21 ETO01358.1 - 0.0099 15.9 1.5 14 6.0 0.1 3.7 3 0 0 3 3 3 1 NHL repeat VID27 PF08553.10 ETO01358.1 - 0.017 14.2 0.0 0.42 9.6 0.0 2.4 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO01358.1 - 0.065 13.2 13.2 4 7.5 0.1 5.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat NYD-SP28_assoc PF14775.6 ETO01358.1 - 0.23 11.6 0.2 7.3 6.8 0.0 3.2 4 0 0 4 4 4 0 Sperm tail C-terminal domain Proteasome_A_N PF10584.9 ETO01358.1 - 4.4 7.1 15.1 11 5.9 0.1 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF1799 PF08809.11 ETO01360.1 - 0.054 13.7 0.1 2.8 8.2 0.0 2.1 2 0 0 2 2 2 0 Phage related hypothetical protein (DUF1799) DMPK_coil PF08826.10 ETO01361.1 - 0.026 14.6 0.6 0.049 13.7 0.6 1.4 1 0 0 1 1 1 0 DMPK coiled coil domain like CEP209_CC5 PF16574.5 ETO01361.1 - 0.036 14.2 0.6 0.036 14.2 0.6 2.0 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 Pre-PUA PF17832.1 ETO01362.1 - 0.11 13.2 1.2 9.6 7.0 0.0 3.5 3 0 0 3 3 3 0 Pre-PUA-like domain SIR2 PF02146.17 ETO01362.1 - 1.9 8.4 7.9 4.4 7.2 2.2 3.7 3 0 0 3 3 3 0 Sir2 family YqzH PF14164.6 ETO01362.1 - 7 6.8 13.7 6 7.0 1.3 4.2 4 0 0 4 4 4 0 YqzH-like protein UCH PF00443.29 ETO01364.1 - 7.9e-08 32.1 0.9 7.9e-08 32.1 0.9 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ETO01365.1 - 4.3e-42 141.3 17.1 2.6e-10 40.7 0.9 4.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01365.1 - 7.1e-17 61.5 3.0 0.00055 20.2 0.0 4.4 2 1 3 5 5 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01365.1 - 1.6e-11 44.1 1.2 3.2e-05 23.4 0.0 3.6 2 1 2 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO01365.1 - 6e-10 38.6 0.6 0.086 11.8 0.0 4.2 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO01365.1 - 1.5e-07 30.4 1.4 0.66 8.6 0.0 4.2 1 1 3 4 4 4 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO01365.1 - 1.8e-07 31.2 0.2 8.6e-06 25.8 0.0 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Pentapeptide PF00805.22 ETO01365.1 - 4.3e-05 23.1 2.6 8.5e-05 22.1 1.9 1.8 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO01365.1 - 6e-05 22.9 4.0 4.5 7.3 0.0 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO01365.1 - 0.0011 19.0 0.9 0.0021 18.2 0.9 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Frtz PF11768.8 ETO01365.1 - 0.0096 14.3 0.0 0.86 7.8 0.0 2.7 1 1 2 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETO01365.1 - 0.021 14.9 7.4 14 5.8 0.1 4.2 1 1 3 4 4 4 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO01365.1 - 0.042 12.4 0.2 0.087 11.3 0.2 1.4 1 1 0 1 1 1 0 Cytochrome D1 heme domain PQQ PF01011.21 ETO01365.1 - 0.12 12.4 0.0 2e+02 2.2 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat Pentapeptide_3 PF13576.6 ETO01365.1 - 0.18 12.0 3.6 0.49 10.6 3.6 1.7 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) GBP_PSP PF02425.15 ETO01366.1 - 0.11 12.1 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Paralytic/GBP/PSP peptide CSG2 PF16965.5 ETO01366.1 - 4.4 6.1 7.8 0.87 8.5 4.2 1.6 1 1 1 2 2 2 0 Ceramide synthase regulator DUF2370 PF10176.9 ETO01366.1 - 4.7 6.8 11.3 0.87 9.2 6.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) Ten_N PF06484.12 ETO01367.1 - 0.0067 16.4 0.7 0.0068 16.3 0.7 1.2 1 0 0 1 1 1 1 Teneurin Intracellular Region PGM_PMM_I PF02878.16 ETO01370.1 - 1.9e-14 53.5 0.1 2e-07 30.8 0.0 3.1 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ETO01370.1 - 0.0063 17.1 0.0 0.025 15.2 0.0 2.1 1 1 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ODAM PF15424.6 ETO01370.1 - 0.098 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 Odontogenic ameloblast-associated family CDC45 PF02724.14 ETO01372.1 - 0.82 7.9 10.5 1.4 7.1 10.5 1.3 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO01373.1 - 0.0053 17.6 3.6 0.024 15.5 0.9 2.9 2 2 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO01374.1 - 8.4e-13 48.6 9.7 4.3e-05 24.2 1.4 3.7 3 2 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01374.1 - 7.1e-05 23.0 0.0 0.035 14.4 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain AstE_AspA PF04952.14 ETO01375.1 - 4.7e-19 68.6 0.0 5.1e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family zf-CCHC PF00098.23 ETO01376.1 - 0.0018 18.3 0.8 0.0018 18.3 0.8 2.4 2 0 0 2 2 2 1 Zinc knuckle RPAP3_C PF13877.6 ETO01376.1 - 0.063 13.8 3.1 0.41 11.2 0.9 2.4 1 1 1 2 2 2 0 Potential Monad-binding region of RPAP3 BORCS8 PF10167.9 ETO01376.1 - 0.11 12.4 5.1 4.5 7.2 0.5 2.8 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 8 zf-CCHC_4 PF14392.6 ETO01376.1 - 1.3 8.8 5.8 1.6 8.6 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle FapA PF03961.13 ETO01378.1 - 0.39 9.3 10.3 0.45 9.1 10.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Intein_splicing PF14890.6 ETO01378.1 - 5.3 7.0 8.5 7.4 6.5 8.5 1.2 1 0 0 1 1 1 0 Intein splicing domain IFP_35_N PF07334.13 ETO01378.1 - 5.8 7.1 12.3 1.8 8.7 4.8 2.8 2 1 1 3 3 3 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus STAC2_u1 PF16664.5 ETO01379.1 - 0.018 15.5 12.4 0.021 15.3 12.4 1.0 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 MMM1 PF10296.9 ETO01379.1 - 0.091 11.8 5.8 0.1 11.7 5.8 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 SRP-alpha_N PF04086.13 ETO01379.1 - 1.2 8.9 20.8 1.5 8.6 20.8 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RR_TM4-6 PF06459.12 ETO01379.1 - 2.7 7.7 18.4 3.1 7.5 18.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3043 PF11241.8 ETO01379.1 - 4 7.4 8.8 5 7.1 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) RNA_polI_A34 PF08208.11 ETO01379.1 - 6.1 6.9 30.2 7 6.7 30.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 ETO01379.1 - 7.7 4.7 19.5 8.6 4.5 19.5 1.0 1 0 0 1 1 1 0 CDC45-like protein VIR_N PF15912.5 ETO01379.1 - 7.8 6.0 12.2 9 5.8 12.2 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal DUF908 PF06012.12 ETO01379.1 - 9.5 5.5 11.6 11 5.4 11.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Peptidase_M9 PF01752.17 ETO01381.1 - 0.83 8.8 6.7 0.82 8.9 6.7 1.0 1 0 0 1 1 1 0 Collagenase Tfb4 PF03850.14 ETO01383.1 - 0.0043 16.6 5.2 0.0053 16.3 5.2 1.1 1 0 0 1 1 1 1 Transcription factor Tfb4 DUF724 PF05266.14 ETO01383.1 - 0.1 12.4 21.8 0.11 12.3 12.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Connexin PF00029.19 ETO01383.1 - 0.14 11.9 5.6 0.16 11.7 5.6 1.2 1 0 0 1 1 1 0 Connexin DUF641 PF04859.12 ETO01383.1 - 0.4 11.0 16.6 0.73 10.2 4.6 2.4 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Csm1_N PF18504.1 ETO01383.1 - 0.44 10.9 22.4 0.69 10.3 4.1 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain Complex1_51K PF01512.17 ETO01383.1 - 0.45 10.4 6.8 9.9 6.0 6.8 2.0 1 1 0 1 1 1 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit HIP1_clath_bdg PF16515.5 ETO01383.1 - 0.56 10.9 18.0 0.97 10.1 7.2 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Macoilin PF09726.9 ETO01383.1 - 5.8 5.4 17.5 0.083 11.4 7.0 2.0 2 0 0 2 2 2 0 Macoilin family HEAT PF02985.22 ETO01385.1 - 3.2e-08 33.2 0.1 0.00044 20.3 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO01385.1 - 4.9e-06 26.8 0.0 7.4e-05 23.1 0.0 2.1 2 0 0 2 2 2 1 HEAT repeats Cnd1 PF12717.7 ETO01385.1 - 2.3e-05 24.5 2.6 0.036 14.1 0.0 2.3 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETO01385.1 - 0.0086 15.7 0.7 0.085 12.4 0.7 2.1 1 1 0 1 1 1 1 CLASP N terminal Tubulin PF00091.25 ETO01386.1 - 2.1e-36 126.0 0.4 1.2e-32 113.7 0.3 2.3 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO01386.1 - 1.1e-17 64.3 0.5 3.8e-12 46.5 0.1 2.4 1 1 1 2 2 2 2 Tubulin C-terminal domain MRP-L20 PF12824.7 ETO01386.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 Lipase_3 PF01764.25 ETO01386.1 - 0.17 11.8 0.0 0.56 10.1 0.0 1.8 2 0 0 2 2 2 0 Lipase (class 3) G3P_acyltransf PF02660.15 ETO01387.1 - 0.079 13.0 6.5 0.095 12.8 6.5 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate acyltransferase DUF2583 PF10762.9 ETO01387.1 - 0.52 10.8 8.4 0.53 10.7 1.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF2583) DUF417 PF04224.12 ETO01387.1 - 1 8.9 5.3 2.2 7.8 5.2 1.8 1 1 0 1 1 1 0 Protein of unknown function, DUF417 FeoB_associated PF12669.7 ETO01387.1 - 3.4 8.1 0.0 3.4 8.1 0.0 2.8 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Phage_holin_2_4 PF16082.5 ETO01387.1 - 4.5 7.1 18.1 4 7.2 0.0 3.5 1 1 1 2 2 2 0 Bacteriophage holin family, superfamily II-like DRMBL PF07522.14 ETO01388.1 - 1.2e-20 73.7 0.1 3.1e-19 69.2 0.0 2.4 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 ETO01388.1 - 0.00098 19.0 0.1 0.0019 18.1 0.1 1.4 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Sep15_SelM PF08806.11 ETO01388.1 - 0.047 13.8 0.2 0.13 12.4 0.2 1.8 1 1 0 1 1 1 0 Sep15/SelM redox domain SH3_16 PF18348.1 ETO01388.1 - 1.6 8.5 5.8 9.8 6.1 2.2 3.0 3 0 0 3 3 3 0 Bacterial dipeptidyl-peptidase Sh3 domain G_glu_transpept PF01019.21 ETO01390.1 - 0.12 11.1 0.1 0.12 11.1 0.1 1.1 1 0 0 1 1 1 0 Gamma-glutamyltranspeptidase PX PF00787.24 ETO01391.1 - 1.8e-07 31.1 1.0 3.9e-07 30.0 0.6 1.7 2 0 0 2 2 2 1 PX domain Ank_2 PF12796.7 ETO01391.1 - 0.0032 18.0 0.0 0.13 12.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) CAF1 PF04857.20 ETO01391.1 - 0.032 13.4 0.4 0.043 13.0 0.4 1.3 1 1 0 1 1 1 0 CAF1 family ribonuclease PPR_2 PF13041.6 ETO01392.1 - 0.00061 19.9 0.8 0.0039 17.3 0.1 2.3 2 0 0 2 2 2 1 PPR repeat family Peptidase_C3 PF00548.20 ETO01392.1 - 0.071 13.0 0.2 0.11 12.4 0.1 1.5 1 1 0 1 1 1 0 3C cysteine protease (picornain 3C) WD40 PF00400.32 ETO01393.1 - 2.6e-151 486.9 60.1 2.7e-11 43.8 0.5 16.2 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01393.1 - 1e-69 230.9 9.0 2.4e-05 24.6 0.0 14.6 2 2 12 14 14 14 14 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01393.1 - 4.7e-38 131.2 0.0 1.3e-05 24.7 0.0 9.4 6 3 2 8 8 8 7 WD40-like domain eIF2A PF08662.11 ETO01393.1 - 2.5e-24 86.2 0.0 0.0008 19.3 0.0 7.0 1 1 6 7 7 7 6 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 ETO01393.1 - 6.4e-14 52.1 8.3 0.0021 17.7 0.2 6.0 1 1 2 4 4 4 4 PQQ-like domain PD40 PF07676.12 ETO01393.1 - 6.6e-10 38.7 10.5 37 4.4 0.0 11.3 11 0 0 11 11 11 0 WD40-like Beta Propeller Repeat Germane PF10646.9 ETO01393.1 - 1.3e-07 32.3 0.0 68 4.3 0.0 8.3 7 2 2 9 9 9 0 Sporulation and spore germination PQQ_3 PF13570.6 ETO01393.1 - 2.1e-07 31.2 0.8 0.72 10.4 0.0 6.9 9 0 0 9 9 7 1 PQQ-like domain PQQ PF01011.21 ETO01393.1 - 6.7e-07 28.9 0.0 9.5 6.3 0.0 8.4 9 0 0 9 9 8 1 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETO01393.1 - 4.6e-05 22.1 8.6 1.5 7.3 0.0 5.7 2 2 2 7 7 7 3 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO01393.1 - 0.00016 21.2 0.1 0.00046 19.8 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DUF1258 PF06869.12 ETO01393.1 - 0.00047 19.7 0.0 59 3.0 0.0 6.0 3 2 3 8 8 8 0 Protein of unknown function (DUF1258) Big_7 PF17957.1 ETO01393.1 - 0.00051 20.8 10.7 64 4.4 0.0 8.9 10 2 0 10 10 8 0 Bacterial Ig domain Pentapeptide_4 PF13599.6 ETO01393.1 - 0.0025 18.0 0.7 0.011 15.9 0.6 1.9 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO01393.1 - 0.015 15.4 23.2 15 5.7 0.1 9.4 4 2 6 11 11 11 0 Family of unknown function (DUF5570) DUF4859 PF16151.5 ETO01393.1 - 0.018 14.9 0.6 6.1 6.8 0.1 4.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4859) Pneumo_M2 PF07380.11 ETO01393.1 - 0.26 11.6 3.6 11 6.3 0.7 2.7 2 0 0 2 2 2 0 Pneumovirus M2 protein DUF5604 PF18300.1 ETO01393.1 - 4.1 7.5 5.6 72 3.5 0.0 5.0 4 1 2 6 6 6 0 Domain of unknown function (DUF5604) PHR PF08005.12 ETO01394.1 - 1.2e-12 48.7 3.5 2e-12 48.0 3.5 1.4 1 1 0 1 1 1 1 PHR domain HSCB_C PF07743.13 ETO01395.1 - 3.3e-07 30.7 8.6 3.3e-07 30.7 8.6 1.9 2 0 0 2 2 2 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 ETO01395.1 - 0.013 15.6 0.2 0.032 14.4 0.2 1.7 1 0 0 1 1 1 0 DnaJ domain DZR PF12773.7 ETO01395.1 - 0.021 14.8 0.8 0.035 14.1 0.8 1.3 1 0 0 1 1 1 0 Double zinc ribbon HIGH_NTase1_ass PF16581.5 ETO01395.1 - 0.023 14.7 5.4 0.037 14.0 4.9 1.5 1 1 0 1 1 1 0 Cytidyltransferase-related C-terminal region CSD PF00313.22 ETO01395.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 'Cold-shock' DNA-binding domain zinc_ribbon_2 PF13240.6 ETO01395.1 - 0.88 9.4 6.9 2.5 8.0 6.7 1.8 1 1 1 2 2 2 0 zinc-ribbon domain zf-ribbon_3 PF13248.6 ETO01395.1 - 2.6 7.6 5.3 12 5.5 1.3 2.2 2 0 0 2 2 2 0 zinc-ribbon domain N6_Mtase PF02384.16 ETO01396.1 - 8e-22 77.9 1.2 3.2e-20 72.6 0.1 2.5 1 1 1 2 2 2 1 N-6 DNA Methylase UPF0020 PF01170.18 ETO01396.1 - 0.00085 19.1 0.6 0.016 14.9 0.5 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 ETO01396.1 - 0.013 15.2 0.4 0.39 10.5 0.0 2.7 3 0 0 3 3 3 0 Methyltransferase domain Wound_ind PF08186.11 ETO01396.1 - 0.045 14.2 0.2 1.4 9.4 0.0 2.6 2 0 0 2 2 2 0 Wound-inducible basic protein family N6_N4_Mtase PF01555.18 ETO01396.1 - 0.047 13.4 5.9 0.1 12.3 5.9 1.5 1 1 0 1 1 1 0 DNA methylase MTS PF05175.14 ETO01396.1 - 0.12 11.9 0.0 0.71 9.4 0.0 2.2 3 0 0 3 3 3 0 Methyltransferase small domain DUF2666 PF10869.8 ETO01396.1 - 1.3 9.3 8.5 1.6 8.9 0.3 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2666) DUF2415 PF10313.9 ETO01397.1 - 0.0067 16.3 0.0 0.014 15.3 0.0 1.5 1 0 0 1 1 1 1 Uncharacterised protein domain (DUF2415) TPR_12 PF13424.6 ETO01398.1 - 6.2e-42 141.8 3.9 1e-17 64.2 0.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01398.1 - 6.2e-29 99.0 5.0 3e-06 26.9 0.3 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01398.1 - 1.9e-28 97.1 31.7 9.3e-09 34.7 4.7 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01398.1 - 6.7e-24 82.0 22.5 3.3e-08 33.0 1.6 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01398.1 - 5.4e-22 76.1 25.4 2.2e-06 27.4 3.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01398.1 - 3.3e-20 70.6 6.3 0.0003 20.6 0.3 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01398.1 - 9.7e-15 54.9 0.0 2.4e-06 28.1 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01398.1 - 9.6e-13 47.9 3.2 0.0059 17.2 0.1 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat SNAP PF14938.6 ETO01398.1 - 1.6e-12 47.5 7.5 8.7e-09 35.2 1.4 2.0 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 ETO01398.1 - 2.8e-12 46.4 0.0 0.0041 17.8 0.0 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01398.1 - 6.3e-11 41.8 26.2 0.00012 21.7 0.1 5.8 5 1 1 6 6 6 4 TPR repeat MIT PF04212.18 ETO01398.1 - 1.4e-07 31.5 18.8 0.039 14.0 0.2 5.0 4 1 1 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO01398.1 - 2.5e-07 30.6 12.3 0.0023 18.2 3.3 5.2 4 2 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO01398.1 - 4.7e-07 29.9 9.5 0.0041 17.3 1.1 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 ETO01398.1 - 2.7e-06 27.3 12.9 0.022 14.5 0.2 3.1 1 1 2 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 ETO01398.1 - 0.00024 21.6 6.2 0.76 10.3 0.5 4.3 2 1 1 4 4 4 2 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO01398.1 - 0.0016 18.0 2.3 8.3 6.1 0.0 4.3 4 0 0 4 4 4 0 Helix-turn-helix bacterial domain SHNi-TPR PF10516.9 ETO01398.1 - 0.002 17.5 3.1 1.3 8.5 0.0 4.4 5 0 0 5 5 5 1 SHNi-TPR Sel1 PF08238.12 ETO01398.1 - 0.0047 17.6 11.0 12 6.7 0.0 5.4 5 1 0 5 5 5 0 Sel1 repeat 14-3-3 PF00244.20 ETO01398.1 - 0.0069 15.9 11.2 0.036 13.6 0.5 3.1 1 1 2 3 3 3 2 14-3-3 protein TPR_5 PF12688.7 ETO01398.1 - 0.0099 16.1 0.3 0.48 10.7 0.0 3.1 1 1 2 3 3 3 1 Tetratrico peptide repeat DUF2950 PF11453.8 ETO01398.1 - 0.027 13.7 1.1 0.029 13.6 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2950) DUF5113 PF17140.4 ETO01398.1 - 0.049 13.4 15.5 0.11 12.4 1.2 3.9 3 1 1 5 5 4 0 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO01398.1 - 0.055 13.5 1.3 0.055 13.5 1.3 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF4254 PF14063.6 ETO01398.1 - 0.061 13.1 0.6 3.3 7.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4254) OEP PF02321.18 ETO01398.1 - 0.064 13.1 1.3 8.4 6.1 0.6 2.5 2 0 0 2 2 2 0 Outer membrane efflux protein TetR_C_19 PF17924.1 ETO01398.1 - 0.12 12.9 3.7 6.2 7.4 0.1 2.8 3 0 0 3 3 2 0 Tetracyclin repressor-like, C-terminal domain SPO22 PF08631.10 ETO01398.1 - 0.19 11.2 7.5 0.37 10.2 0.7 3.1 2 2 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like RPN7 PF10602.9 ETO01398.1 - 0.27 10.9 7.2 0.74 9.5 0.3 3.0 1 1 0 2 2 2 0 26S proteasome subunit RPN7 NSF PF02071.20 ETO01398.1 - 0.69 10.9 19.4 22 6.4 0.1 5.7 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat Sda PF08970.10 ETO01398.1 - 0.96 9.2 9.1 7.2 6.4 0.3 4.4 4 0 0 4 4 4 0 Sporulation inhibitor A Vps39_1 PF10366.9 ETO01398.1 - 1.3 9.4 8.5 8.1 6.8 0.1 3.8 1 1 3 4 4 4 0 Vacuolar sorting protein 39 domain 1 DUF1296 PF06972.11 ETO01400.1 - 0.042 14.0 0.2 0.073 13.2 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1296) WD40 PF00400.32 ETO01402.1 - 5.4e-15 55.5 4.0 6.9e-06 26.7 0.2 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01402.1 - 0.00026 21.2 0.1 0.061 13.6 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01402.1 - 0.00028 19.7 0.4 0.11 11.1 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO01402.1 - 0.0018 17.1 1.0 0.032 13.0 0.1 2.0 1 1 1 2 2 2 2 Nup133 N terminal like zf-RING_7 PF02591.15 ETO01403.1 - 0.002 18.2 0.1 0.66 10.2 0.0 2.4 2 0 0 2 2 2 2 C4-type zinc ribbon domain NurA PF09376.10 ETO01403.1 - 0.0056 16.4 0.2 0.017 14.8 0.2 1.7 1 1 0 1 1 1 1 NurA domain Ogr_Delta PF04606.12 ETO01403.1 - 0.0076 16.2 0.1 1.1 9.3 0.0 2.5 2 0 0 2 2 2 1 Ogr/Delta-like zinc finger Cys_rich_CPXG PF14255.6 ETO01403.1 - 0.013 15.3 0.7 0.023 14.6 0.7 1.4 1 0 0 1 1 1 0 Cysteine-rich CPXCG zinc_ribbon_10 PF10058.9 ETO01403.1 - 0.02 14.6 0.6 0.039 13.7 0.6 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Lar_restr_allev PF14354.6 ETO01403.1 - 0.077 13.4 0.1 0.14 12.6 0.1 1.4 1 0 0 1 1 1 0 Restriction alleviation protein Lar zinc_ribbon_9 PF14369.6 ETO01403.1 - 2.3 8.5 4.6 17 5.8 0.2 2.5 1 1 1 2 2 2 0 zinc-ribbon NACHT PF05729.12 ETO01405.1 - 1.6e-09 37.9 0.0 2.7e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO01405.1 - 4e-06 27.4 0.4 1.4e-05 25.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO01405.1 - 2.7e-05 24.5 0.2 9e-05 22.8 0.1 2.0 1 1 0 1 1 1 1 AAA domain ATP_bind_2 PF03668.15 ETO01405.1 - 0.0021 17.4 0.0 0.008 15.5 0.0 1.9 2 0 0 2 2 2 1 P-loop ATPase protein family RsgA_GTPase PF03193.16 ETO01405.1 - 0.003 17.5 0.3 0.029 14.3 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA PF00004.29 ETO01405.1 - 0.006 17.0 0.2 0.013 15.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO01405.1 - 0.01 15.8 0.0 0.022 14.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 ETO01405.1 - 0.01 15.8 0.0 0.044 13.8 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 ETO01405.1 - 0.013 15.2 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 ETO01405.1 - 0.022 15.1 4.5 0.053 13.9 0.1 2.9 1 1 1 2 2 2 0 RNA helicase AAA_16 PF13191.6 ETO01405.1 - 0.033 14.6 0.1 0.26 11.6 0.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO01405.1 - 0.046 14.2 1.4 0.069 13.7 0.7 1.7 1 1 0 1 1 1 0 ABC transporter PRK PF00485.18 ETO01405.1 - 0.049 13.4 0.2 0.3 10.8 0.0 2.2 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 ETO01405.1 - 0.074 13.2 0.0 0.14 12.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ETO01405.1 - 0.094 12.5 4.9 4.7 6.9 2.2 2.4 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Yippee-Mis18 PF03226.14 ETO01406.1 - 8.4e-09 35.6 5.2 1.5e-08 34.8 5.2 1.4 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly BUD22 PF09073.10 ETO01406.1 - 0.0073 15.7 18.1 0.031 13.6 6.9 2.1 2 0 0 2 2 2 2 BUD22 Myc_N PF01056.18 ETO01406.1 - 0.024 14.6 18.6 0.077 12.9 1.1 2.1 2 0 0 2 2 2 0 Myc amino-terminal region THEG4 PF15834.5 ETO01406.1 - 0.12 12.4 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Testis highly expressed protein 4 SDA1 PF05285.12 ETO01406.1 - 0.77 9.1 27.9 0.46 9.8 5.0 2.2 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ETO01406.1 - 2.3 6.3 30.4 0.14 10.4 5.5 2.0 2 0 0 2 2 2 0 Nop14-like family DUF913 PF06025.12 ETO01406.1 - 3.5 6.5 12.1 1.9 7.4 3.6 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SAPS PF04499.15 ETO01406.1 - 3.6 6.2 14.2 2.3 6.9 5.0 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Sigma70_ner PF04546.13 ETO01406.1 - 7.1 6.5 19.4 0.21 11.4 2.9 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF2681 PF10883.8 ETO01407.1 - 0.11 12.9 1.3 0.19 12.2 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) RDD PF06271.12 ETO01408.1 - 0.085 13.1 1.1 0.16 12.1 1.1 1.4 1 0 0 1 1 1 0 RDD family zf-TRAF PF02176.18 ETO01409.1 - 2.8e-05 24.7 5.6 2.8e-05 24.7 5.6 2.6 3 1 1 4 4 4 1 TRAF-type zinc finger Geminin PF07412.12 ETO01409.1 - 0.016 14.9 3.3 0.016 14.9 3.3 3.9 2 1 2 4 4 4 0 Geminin Metal_CEHH PF14455.6 ETO01409.1 - 0.18 11.4 1.3 0.5 10.0 0.2 2.1 2 0 0 2 2 2 0 Predicted metal binding domain DUF4407 PF14362.6 ETO01409.1 - 0.21 10.9 9.2 0.28 10.5 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF641 PF04859.12 ETO01409.1 - 0.26 11.6 19.0 11 6.4 15.5 3.1 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) CENP-H PF05837.12 ETO01409.1 - 0.71 10.3 18.8 0.32 11.4 11.2 2.8 1 1 1 2 2 2 0 Centromere protein H (CENP-H) bZIP_1 PF00170.21 ETO01409.1 - 4.3 7.5 16.9 1.1 9.4 4.4 3.5 1 1 2 3 3 3 0 bZIP transcription factor DUF1192 PF06698.11 ETO01409.1 - 9.6 6.3 8.1 22 5.2 0.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Pneumo_M2 PF07380.11 ETO01414.1 - 0.028 14.7 2.2 0.028 14.7 2.2 1.9 1 1 0 1 1 1 0 Pneumovirus M2 protein AC_N PF16214.5 ETO01418.1 - 0.43 9.7 6.2 0.53 9.4 6.2 1.1 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region GREB1 PF15782.5 ETO01418.1 - 7 3.6 17.1 8.6 3.3 17.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ras PF00071.22 ETO01419.1 - 2.4e-06 27.2 0.0 2.9e-06 27.0 0.0 1.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO01419.1 - 8.5e-05 22.8 1.1 0.00028 21.1 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF4299 PF14132.6 ETO01419.1 - 0.0074 15.7 0.0 0.0074 15.7 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4299) DNA_primase_S PF01896.19 ETO01419.1 - 0.18 11.8 2.6 0.24 11.4 2.3 1.3 1 1 0 1 1 1 0 DNA primase small subunit SR-25 PF10500.9 ETO01419.1 - 4 7.0 18.4 5.1 6.6 18.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein HCR PF07111.12 ETO01420.1 - 0.33 9.0 0.2 0.39 8.7 0.2 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) RRM_1 PF00076.22 ETO01421.1 - 0.0002 21.1 0.1 0.00092 19.0 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GldM_N PF12081.8 ETO01421.1 - 0.0053 16.9 3.8 0.0053 16.9 3.8 1.6 2 0 0 2 2 2 1 GldM N-terminal domain Na_Ca_ex_C PF16494.5 ETO01421.1 - 1.2 9.6 9.3 2.2 8.7 9.3 1.7 1 1 0 1 1 1 0 C-terminal extension of sodium/calcium exchanger domain CREPT PF16566.5 ETO01421.1 - 1.8 8.7 9.7 53 4.0 9.7 2.3 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour V_ATPase_I PF01496.19 ETO01421.1 - 3.3 5.5 9.0 0.61 7.9 5.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Syntaxin-6_N PF09177.11 ETO01421.1 - 4.6 7.9 11.7 16 6.1 11.6 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal MRP-S27 PF10037.9 ETO01421.1 - 6.8 5.4 16.4 20 3.9 16.4 1.8 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S27 Exonuc_VII_L PF02601.15 ETO01421.1 - 8.3 5.9 8.7 10 5.6 8.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPR3 PF03666.13 ETO01422.1 - 2.4 6.9 9.1 3 6.5 9.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 ETO01422.1 - 8.6 5.1 6.6 10 4.8 6.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter ERM PF00769.19 ETO01423.1 - 0.011 15.6 44.2 0.015 15.1 44.2 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3584 PF12128.8 ETO01423.1 - 0.017 12.7 40.8 0.022 12.3 40.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MAJIN PF15077.6 ETO01423.1 - 0.091 12.5 14.8 0.12 12.2 14.8 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein CALCOCO1 PF07888.11 ETO01423.1 - 0.18 10.7 40.1 0.22 10.4 40.1 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like LMBR1 PF04791.16 ETO01423.1 - 0.34 9.8 23.4 0.43 9.4 23.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_15 PF13175.6 ETO01423.1 - 0.62 9.7 32.0 0.88 9.2 32.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Hid1 PF12722.7 ETO01423.1 - 0.77 7.8 22.3 0.88 7.6 22.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Fusion_gly PF00523.18 ETO01423.1 - 1.6 6.9 20.0 2.4 6.3 11.3 2.2 1 1 1 2 2 2 0 Fusion glycoprotein F0 MAP7 PF05672.11 ETO01423.1 - 2.3 7.9 48.7 3.3 7.4 48.7 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Neur_chan_memb PF02932.16 ETO01423.1 - 4.2 7.4 14.6 5.5 7.0 14.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Phasin PF05597.11 ETO01423.1 - 4.6 7.3 31.8 0.033 14.2 13.9 2.3 1 1 1 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) Spc7 PF08317.11 ETO01423.1 - 7.1 5.4 48.1 14 4.4 48.1 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein SKA1 PF07160.12 ETO01423.1 - 7.9 6.3 38.6 3 7.6 0.5 2.8 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 Atg14 PF10186.9 ETO01423.1 - 8.3 5.4 45.0 28 3.7 45.0 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 ETO01423.1 - 8.5 5.8 34.1 16 4.9 34.1 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit SLC12 PF03522.15 ETO01423.1 - 9.6 5.1 25.1 12 4.8 25.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TMEM138 PF14935.6 ETO01425.1 - 0.012 16.3 2.0 0.018 15.7 2.0 1.2 1 0 0 1 1 1 0 Transmembrane protein 138 Synaptobrevin PF00957.21 ETO01425.1 - 0.073 12.9 1.2 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 Synaptobrevin Cnn_1N PF07989.11 ETO01425.1 - 3.4 7.9 8.2 2.1 8.6 0.5 3.1 3 0 0 3 3 3 0 Centrosomin N-terminal motif 1 DUF4050 PF13259.6 ETO01428.1 - 0.022 15.1 8.4 0.027 14.8 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Pex14_N PF04695.13 ETO01428.1 - 0.062 14.0 4.0 0.072 13.8 4.0 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NPR3 PF03666.13 ETO01428.1 - 0.064 12.0 12.0 0.07 11.9 12.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4614 PF15391.6 ETO01428.1 - 0.11 12.5 9.5 0.11 12.4 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) FXMRP1_C_core PF12235.8 ETO01428.1 - 0.19 12.4 11.7 0.23 12.1 11.7 1.2 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal DUF1635 PF07795.11 ETO01428.1 - 0.46 10.3 5.9 0.49 10.2 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) PNISR PF15996.5 ETO01428.1 - 0.51 10.6 6.2 0.59 10.4 6.2 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Menin PF05053.13 ETO01428.1 - 1.2 7.4 10.1 1.2 7.4 10.1 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO01428.1 - 1.3 7.7 11.1 1.4 7.7 11.1 1.0 1 0 0 1 1 1 0 Presenilin YscJ_FliF_C PF08345.11 ETO01428.1 - 1.9 8.8 17.3 2.5 8.4 17.3 1.1 1 0 0 1 1 1 0 Flagellar M-ring protein C-terminal Transformer PF06495.11 ETO01428.1 - 2.1 8.4 12.1 2.6 8.1 12.1 1.2 1 0 0 1 1 1 0 Fruit fly transformer protein Pannexin_like PF12534.8 ETO01428.1 - 2.4 7.2 5.6 2.8 6.9 5.6 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Secretin_N_2 PF07655.13 ETO01428.1 - 3.2 8.3 28.6 5.7 7.5 28.6 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain AAR2 PF05282.11 ETO01428.1 - 3.8 6.8 12.1 4.3 6.6 12.1 1.0 1 0 0 1 1 1 0 AAR2 protein NAM-associated PF14303.6 ETO01428.1 - 4 8.1 16.7 5.9 7.6 16.7 1.3 1 1 0 1 1 1 0 No apical meristem-associated C-terminal domain Apis_Csd PF11671.8 ETO01428.1 - 4.4 7.3 28.0 5.4 7.0 27.7 1.4 1 1 0 1 1 1 0 Complementary sex determiner protein ALMT PF11744.8 ETO01428.1 - 5.9 5.6 7.8 6.4 5.5 7.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2956 PF11169.8 ETO01428.1 - 7.5 6.8 6.4 12 6.1 6.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2956) Apt1 PF10351.9 ETO01428.1 - 8.8 5.1 17.8 10 4.9 17.8 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF5320 PF17253.2 ETO01429.1 - 1.7 9.8 27.3 0.088 13.9 20.7 2.1 2 1 0 2 2 2 0 Family of unknown function (DUF5320) zf-RRPl_C4 PF17026.5 ETO01430.1 - 0.022 14.8 1.3 0.025 14.7 1.3 1.2 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-MIZ PF02891.20 ETO01430.1 - 0.028 14.2 0.4 0.044 13.5 0.4 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Kelch_1 PF01344.25 ETO01431.1 - 3.8e-07 29.6 1.7 2.9e-05 23.6 0.3 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO01431.1 - 0.00015 21.9 2.1 0.022 15.1 0.2 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO01431.1 - 0.00046 20.1 2.1 0.46 10.5 0.4 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO01431.1 - 0.0012 18.8 2.7 0.25 11.4 0.4 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO01431.1 - 0.023 15.0 0.1 0.64 10.4 0.0 3.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO01431.1 - 0.15 12.1 0.2 0.56 10.3 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain TPR_8 PF13181.6 ETO01432.1 - 2.1e-07 30.6 0.2 6.2e-07 29.1 0.2 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01432.1 - 1.6e-05 24.6 0.0 3.9e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01432.1 - 8.1e-05 22.3 0.9 0.00014 21.5 0.2 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO01432.1 - 0.001 19.3 0.0 0.0017 18.6 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01432.1 - 0.0026 18.3 0.0 0.15 12.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO01432.1 - 0.0035 17.2 0.3 0.0051 16.6 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5113) Collagen_bind_2 PF12904.7 ETO01432.1 - 0.019 14.9 1.7 0.022 14.7 0.8 1.7 2 0 0 2 2 2 0 Putative collagen-binding domain of a collagenase TED_complement PF07678.14 ETO01432.1 - 0.023 13.7 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 A-macroglobulin TED domain TPR_10 PF13374.6 ETO01432.1 - 0.056 13.3 0.0 0.14 12.0 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO01432.1 - 0.12 13.1 0.2 0.47 11.2 0.0 2.0 2 0 0 2 2 2 0 Sel1 repeat TPR_7 PF13176.6 ETO01432.1 - 0.14 12.3 0.0 0.69 10.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Terminase_5 PF06056.12 ETO01432.1 - 0.27 11.2 1.8 0.3 11.0 0.3 1.8 2 0 0 2 2 2 0 Putative ATPase subunit of terminase (gpP-like) FRG2 PF15315.6 ETO01434.1 - 7.7 6.7 15.5 6 7.0 14.5 1.3 1 1 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 ETRAMP PF09716.10 ETO01435.1 - 0.72 10.0 3.9 0.9 9.6 3.9 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PseudoU_synth_2 PF00849.22 ETO01436.1 - 0.0028 17.8 0.4 0.0033 17.5 0.4 1.2 1 1 0 1 1 1 1 RNA pseudouridylate synthase BLUF PF04940.12 ETO01436.1 - 0.067 13.3 0.1 0.099 12.8 0.1 1.3 1 0 0 1 1 1 0 Sensors of blue-light using FAD Ank_3 PF13606.6 ETO01437.1 - 6.6e-08 32.2 0.1 0.0002 21.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ETO01437.1 - 3.1e-06 27.7 0.0 5.2e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO01437.1 - 6.4e-06 26.4 0.0 1.6e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO01437.1 - 0.00034 21.1 0.1 0.00098 19.6 0.1 1.8 1 1 0 1 1 1 1 Ankyrin repeats (many copies) ACCA PF03255.14 ETO01437.1 - 0.00095 19.1 0.1 0.0013 18.6 0.1 1.1 1 0 0 1 1 1 1 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Ank PF00023.30 ETO01437.1 - 0.0015 18.9 0.0 0.017 15.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat HEAT PF02985.22 ETO01439.1 - 3e-13 48.8 0.0 0.0021 18.2 0.0 3.2 3 0 0 3 3 3 3 HEAT repeat HEAT_2 PF13646.6 ETO01439.1 - 4.3e-09 36.6 0.0 0.00035 20.9 0.0 2.1 1 1 1 2 2 2 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO01439.1 - 1.1e-07 32.4 2.1 0.0016 19.0 0.1 2.6 1 1 2 3 3 3 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETO01439.1 - 2.6e-06 27.6 0.4 1.5e-05 25.1 0.4 2.0 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETO01439.1 - 4.4e-06 26.6 1.2 0.016 14.9 0.2 2.6 1 1 2 3 3 3 3 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 ETO01439.1 - 1.6e-05 25.3 0.0 0.02 15.4 0.0 3.0 2 1 1 3 3 3 1 HEAT-like repeat KAP PF05804.12 ETO01439.1 - 0.0004 18.7 2.1 0.71 7.9 0.1 3.0 1 1 2 3 3 3 2 Kinesin-associated protein (KAP) RTP1_C1 PF10363.9 ETO01439.1 - 0.00098 19.3 0.0 0.0017 18.5 0.0 1.5 1 1 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 Adaptin_N PF01602.20 ETO01439.1 - 0.0017 17.0 0.3 0.0017 17.0 0.3 1.1 1 0 0 1 1 1 1 Adaptin N terminal region IFRD PF05004.13 ETO01439.1 - 0.0049 16.0 0.3 5.5 6.0 0.0 2.6 1 1 2 3 3 3 2 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 ETO01439.1 - 0.0088 15.6 0.1 0.017 14.7 0.1 1.6 1 1 0 1 1 1 1 CLASP N terminal Arm-DNA-bind_2 PF12167.8 ETO01439.1 - 0.0095 15.8 0.0 1.8 8.5 0.0 2.4 2 0 0 2 2 2 1 Arm DNA-binding domain Spore_Cse60 PF10957.8 ETO01439.1 - 0.033 14.2 1.8 0.64 10.1 0.1 2.6 3 0 0 3 3 3 0 Sporulation protein Cse60 Gcn1_N PF12074.8 ETO01439.1 - 0.033 13.5 0.1 0.042 13.2 0.1 1.1 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Med23 PF11573.8 ETO01439.1 - 0.044 11.5 0.3 0.11 10.2 0.3 1.4 1 1 1 2 2 2 0 Mediator complex subunit 23 MutL_C PF08676.11 ETO01439.1 - 0.045 13.5 0.3 7.3 6.3 0.0 2.6 1 1 2 3 3 3 0 MutL C terminal dimerisation domain PAS_10 PF13596.6 ETO01439.1 - 0.067 13.8 0.3 10 6.8 0.0 2.5 1 1 2 3 3 3 0 PAS domain Ribosomal_S3Ae PF01015.18 ETO01439.1 - 0.068 12.7 0.9 0.32 10.6 0.1 2.1 1 1 1 2 2 2 0 Ribosomal S3Ae family CRM1_C PF08767.11 ETO01439.1 - 0.077 12.1 0.1 2.5 7.2 0.0 2.0 1 1 2 3 3 3 0 CRM1 C terminal GhoS PF11080.8 ETO01439.1 - 0.096 12.7 0.1 1.5 8.9 0.0 2.1 1 1 1 2 2 2 0 Endoribonuclease GhoS CCDC-167 PF15188.6 ETO01439.1 - 0.21 11.9 2.1 1.2 9.5 0.9 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 WD40 PF00400.32 ETO01442.1 - 9.3e-08 32.6 0.1 0.0084 16.9 0.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO01442.1 - 0.0011 18.4 1.9 0.0019 17.6 1.6 1.5 2 0 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO01442.1 - 0.032 14.5 0.1 0.81 10.0 0.0 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 ETO01443.1 - 0.11 12.8 0.0 5.9 7.3 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats TPR_12 PF13424.6 ETO01444.1 - 1.9e-107 351.7 11.3 2.6e-26 91.7 0.2 4.0 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01444.1 - 4.9e-67 220.2 0.0 1.2e-11 44.1 0.0 6.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01444.1 - 1.7e-54 179.5 34.5 1.6e-11 43.5 2.0 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01444.1 - 6.5e-53 172.9 3.1 1.4e-09 37.3 0.0 6.1 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01444.1 - 1.8e-42 140.0 38.9 1e-08 34.7 1.7 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01444.1 - 1.2e-41 137.4 28.6 1.2e-08 34.4 0.9 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01444.1 - 1.3e-27 94.2 11.9 4.4e-05 23.6 0.1 7.1 6 2 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01444.1 - 5.7e-27 94.1 0.0 0.00021 21.8 0.0 6.0 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01444.1 - 1.6e-18 65.8 0.0 0.034 14.9 0.0 6.2 2 2 4 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01444.1 - 8.9e-17 60.5 2.8 0.076 13.7 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01444.1 - 3.5e-16 58.6 38.2 1.3e-06 28.0 4.6 9.4 3 2 3 7 7 7 3 TPR repeat MIT PF04212.18 ETO01444.1 - 5.3e-12 45.6 24.4 0.0016 18.5 0.5 6.0 5 1 1 6 6 6 4 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO01444.1 - 8e-12 45.5 0.7 0.00031 21.2 0.1 3.7 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO01444.1 - 1.2e-10 41.3 0.0 6.2e-05 22.5 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region DUF5113 PF17140.4 ETO01444.1 - 2.1e-10 40.6 17.4 0.16 11.8 0.2 6.0 4 2 2 6 6 6 3 Domain of unknown function (DUF5113) PPR PF01535.20 ETO01444.1 - 2.7e-10 39.8 13.4 0.008 16.4 0.1 5.7 6 0 0 6 6 6 3 PPR repeat TPR_3 PF07720.12 ETO01444.1 - 4.7e-10 39.3 20.0 0.028 14.4 0.9 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO01444.1 - 1.3e-09 38.1 13.2 0.0012 19.0 0.8 4.9 1 1 5 6 6 6 5 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ETO01444.1 - 4.2e-09 36.2 7.7 3.1e-08 33.4 2.3 3.3 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 ETO01444.1 - 2.6e-07 30.5 9.9 0.41 10.3 0.1 4.7 2 2 3 5 5 5 3 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 ETO01444.1 - 4.4e-07 29.2 0.2 0.86 9.1 0.0 6.0 6 0 0 6 6 6 1 SHNi-TPR DUF4810 PF16068.5 ETO01444.1 - 5.5e-06 26.8 7.6 1 10.0 0.4 5.2 4 1 2 6 6 6 2 Domain of unknown function (DUF4810) HTH_Bact PF18768.1 ETO01444.1 - 8.4e-05 22.1 6.5 15 5.3 0.1 6.6 6 1 1 7 7 7 0 Helix-turn-helix bacterial domain TPR_9 PF13371.6 ETO01444.1 - 0.00054 20.1 0.0 0.26 11.4 0.0 3.2 2 1 0 3 3 3 1 Tetratricopeptide repeat Pep3_Vps18 PF05131.14 ETO01444.1 - 0.0012 18.7 5.8 14 5.5 0.0 5.1 4 1 1 5 5 5 0 Pep3/Vps18/deep orange family Fis1_TPR_C PF14853.6 ETO01444.1 - 0.0012 18.8 18.2 2.6 8.2 0.1 6.1 6 0 0 6 6 6 1 Fis1 C-terminal tetratricopeptide repeat KH_4 PF13083.6 ETO01444.1 - 0.0013 18.5 0.0 0.92 9.4 0.0 3.3 1 1 3 4 4 4 1 KH domain Clathrin PF00637.20 ETO01444.1 - 0.0021 17.9 10.3 4.1 7.3 0.2 5.4 1 1 2 4 4 4 0 Region in Clathrin and VPS DUF2225 PF09986.9 ETO01444.1 - 0.0029 17.4 6.3 0.13 11.9 3.3 2.7 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) bMG1 PF17970.1 ETO01444.1 - 0.004 17.2 0.0 27 4.9 0.0 4.6 1 1 5 6 6 6 0 Bacterial Alpha-2-macroglobulin MG1 domain DUF627 PF04781.12 ETO01444.1 - 0.012 15.6 7.4 10 6.2 0.1 4.6 2 1 3 5 5 5 0 Protein of unknown function (DUF627) Mob_Pre PF01076.19 ETO01444.1 - 0.019 14.8 6.8 0.14 11.9 0.3 3.3 1 1 2 3 3 3 0 Plasmid recombination enzyme Sel1 PF08238.12 ETO01444.1 - 0.03 15.0 17.0 4.8 8.0 0.3 6.6 6 3 0 6 6 5 0 Sel1 repeat BAR_3 PF16746.5 ETO01444.1 - 0.034 13.9 7.1 1.9 8.1 0.2 3.7 4 1 0 4 4 4 0 BAR domain of APPL family TetR_C_19 PF17924.1 ETO01444.1 - 0.055 14.1 3.9 1.5 9.4 0.0 3.4 4 0 0 4 4 3 0 Tetracyclin repressor-like, C-terminal domain CLTH PF10607.9 ETO01444.1 - 0.06 13.2 2.0 2.3 8.1 0.1 2.7 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain SPO22 PF08631.10 ETO01444.1 - 0.062 12.8 9.4 0.91 8.9 0.2 4.0 3 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like TPR_21 PF09976.9 ETO01444.1 - 0.093 12.4 3.5 2.7 7.7 0.2 3.5 2 1 1 3 3 3 0 Tetratricopeptide repeat-like domain ChuX_HutX PF06228.13 ETO01444.1 - 0.12 12.2 0.0 7.8 6.3 0.0 3.2 1 1 3 4 4 4 0 Haem utilisation ChuX/HutX Intimin_C PF07979.11 ETO01444.1 - 0.23 11.9 6.5 1.9 8.9 0.1 3.5 1 1 2 3 3 3 0 Intimin C-type lectin domain Rota_NSP3 PF01665.16 ETO01444.1 - 0.23 10.5 6.5 12 4.9 0.1 3.8 1 1 3 4 4 4 0 Rotavirus non-structural protein NSP3 PPR_2 PF13041.6 ETO01444.1 - 0.88 9.8 9.4 12 6.2 0.1 4.3 5 0 0 5 5 4 0 PPR repeat family DUF3450 PF11932.8 ETO01444.1 - 4.4 6.5 8.4 26 4.0 0.1 3.8 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Mad3_BUB1_I PF08311.12 ETO01444.1 - 4.6 7.2 10.5 15 5.6 0.1 4.1 5 0 0 5 5 4 0 Mad3/BUB1 homology region 1 Tim44 PF04280.15 ETO01446.1 - 0.15 12.1 0.0 0.2 11.8 0.0 1.2 1 0 0 1 1 1 0 Tim44-like domain AAA_5 PF07728.14 ETO01447.1 - 3.8e-05 23.7 0.0 7.5e-05 22.7 0.0 1.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO01447.1 - 9.4e-05 22.0 0.1 0.00016 21.2 0.1 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETO01447.1 - 0.0001 22.8 0.0 0.00024 21.6 0.0 1.6 2 0 0 2 2 2 1 ABC transporter AAA PF00004.29 ETO01447.1 - 0.00038 20.9 0.0 0.00086 19.7 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ETO01447.1 - 0.0026 17.7 0.1 0.041 13.8 0.1 2.3 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ETO01447.1 - 0.0028 17.9 0.0 0.02 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETO01447.1 - 0.0055 16.6 0.0 0.0085 16.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase NACHT PF05729.12 ETO01447.1 - 0.0059 16.5 0.0 0.22 11.4 0.0 2.5 2 1 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 ETO01447.1 - 0.031 14.3 0.0 0.059 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO01447.1 - 0.047 14.1 0.0 0.076 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain HTH_27 PF13463.6 ETO01447.1 - 0.066 13.7 0.1 23 5.6 0.0 2.6 2 1 0 2 2 2 0 Winged helix DNA-binding domain AAA_21 PF13304.6 ETO01447.1 - 0.069 12.9 0.0 0.098 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TsaE PF02367.17 ETO01447.1 - 0.078 13.0 0.3 0.18 11.8 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 ETO01447.1 - 0.11 11.5 0.0 1.2 8.2 0.0 2.3 2 1 0 2 2 2 0 MCM P-loop domain Mga PF05043.13 ETO01447.1 - 0.11 13.0 0.0 19 5.9 0.0 2.3 2 0 0 2 2 2 0 Mga helix-turn-helix domain RNA_helicase PF00910.22 ETO01447.1 - 0.12 12.7 0.1 0.25 11.7 0.1 1.7 1 1 0 1 1 1 0 RNA helicase Peptidase_C12 PF01088.21 ETO01449.1 - 0.0062 16.3 0.4 0.0065 16.2 0.4 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Folliculin_C PF16692.5 ETO01449.1 - 0.072 12.8 0.7 0.075 12.7 0.7 1.1 1 0 0 1 1 1 0 Folliculin C-terminal domain DUF4519 PF15012.6 ETO01449.1 - 3.2 8.0 7.3 4.9 7.4 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) WD40 PF00400.32 ETO01450.1 - 2.2e-14 53.6 11.6 3.3e-05 24.5 0.0 4.3 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO01450.1 - 8.9e-05 21.3 3.0 0.42 9.2 0.1 3.1 2 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO01451.1 - 3.8e-34 116.1 16.7 1.5e-06 28.8 0.3 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01451.1 - 7.1e-12 45.5 1.0 0.0084 16.4 0.0 5.4 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01451.1 - 2.7e-08 32.9 3.6 0.0012 17.6 0.1 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO01451.1 - 9.2e-08 32.7 2.5 4e-07 30.6 2.5 2.2 1 0 0 1 1 1 1 TRAF-type zinc finger Marek_SORF3 PF07153.11 ETO01451.1 - 0.12 11.7 0.0 11 5.2 0.0 2.2 2 0 0 2 2 2 0 Marek's disease-like virus SORF3 protein DUF4407 PF14362.6 ETO01451.1 - 0.18 11.1 14.6 0.27 10.5 14.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KASH_CCD PF14662.6 ETO01451.1 - 4.8 7.0 39.3 17 5.2 28.1 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TPR_12 PF13424.6 ETO01452.1 - 2.5e-27 95.0 1.0 4.9e-16 58.8 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01452.1 - 4e-14 52.0 0.0 5.9e-05 22.8 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01452.1 - 1.3e-13 50.1 9.2 2.8e-05 23.7 0.7 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01452.1 - 2.1e-12 46.2 6.6 0.0037 17.4 0.2 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01452.1 - 1.6e-11 43.3 0.3 0.00099 19.0 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01452.1 - 2e-08 33.7 4.5 0.0096 16.0 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01452.1 - 9e-08 31.7 2.1 0.03 14.0 0.0 3.8 3 0 0 3 3 3 2 TPR repeat MIT PF04212.18 ETO01452.1 - 0.00087 19.3 1.5 6 7.0 0.0 3.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain Kelch_5 PF13854.6 ETO01452.1 - 0.0023 17.9 0.5 0.41 10.7 0.1 4.0 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO01452.1 - 0.0031 17.7 5.4 0.81 10.1 0.1 4.6 3 1 1 4 4 4 1 Kelch motif TPR_17 PF13431.6 ETO01452.1 - 0.12 12.8 1.2 57 4.4 0.2 4.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO01452.1 - 0.13 11.7 0.1 2 8.0 0.0 2.3 2 0 0 2 2 2 0 SHNi-TPR Kelch_4 PF13418.6 ETO01452.1 - 0.27 11.3 0.7 6.1 6.9 0.0 3.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO01452.1 - 2.3 8.3 6.5 11 6.2 0.1 4.7 5 0 0 5 5 5 0 Kelch motif DUF3573 PF12097.8 ETO01453.1 - 0.096 11.5 3.6 0.11 11.3 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DivIC PF04977.15 ETO01453.1 - 0.24 11.2 5.7 0.41 10.5 4.1 2.0 2 0 0 2 2 2 0 Septum formation initiator bZIP_2 PF07716.15 ETO01453.1 - 4 7.6 11.9 9.2 6.4 6.9 2.3 2 0 0 2 2 2 0 Basic region leucine zipper IL34 PF15036.6 ETO01454.1 - 0.0082 16.2 1.0 0.017 15.2 1.0 1.5 1 1 0 1 1 1 1 Interleukin 34 Peptidase_M29 PF02073.15 ETO01455.1 - 0.02 13.7 0.5 0.022 13.6 0.5 1.1 1 0 0 1 1 1 0 Thermophilic metalloprotease (M29) VasL PF12486.8 ETO01457.1 - 0.033 14.0 1.0 0.042 13.7 1.0 1.3 1 1 0 1 1 1 0 Type VI secretion system, EvfB, or VasL CR6_interact PF10147.9 ETO01457.1 - 0.38 10.4 11.2 0.49 10.1 11.2 1.1 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 DUF4094 PF13334.6 ETO01457.1 - 0.41 11.1 3.2 0.72 10.3 3.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) DUF4140 PF13600.6 ETO01457.1 - 1.1 9.8 3.1 1.6 9.2 3.0 1.5 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Aminotran_1_2 PF00155.21 ETO01458.1 - 3.5e-08 33.0 0.2 2.4e-07 30.2 0.2 2.0 1 1 0 1 1 1 1 Aminotransferase class I and II ADH_zinc_N PF00107.26 ETO01459.1 - 4.9e-20 71.8 0.0 1.1e-19 70.7 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO01459.1 - 2e-13 51.6 0.0 4.9e-13 50.3 0.0 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO01459.1 - 1.8e-05 24.6 0.4 0.00056 19.8 0.1 2.5 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Thioredoxin PF00085.20 ETO01460.1 - 1.6e-17 63.4 0.1 2.6e-17 62.7 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin OST3_OST6 PF04756.13 ETO01460.1 - 0.00042 19.8 0.3 0.00063 19.2 0.2 1.6 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Curlin_rpt PF07012.12 ETO01460.1 - 0.0074 16.3 0.0 0.083 12.9 0.0 2.2 1 1 0 1 1 1 1 Curlin associated repeat Thioredoxin_2 PF13098.6 ETO01460.1 - 0.022 15.2 0.1 0.081 13.4 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin-like domain DSBA PF01323.20 ETO01460.1 - 0.091 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 DSBA-like thioredoxin domain TLD PF07534.16 ETO01461.1 - 6.3e-13 49.1 1.0 3e-11 43.7 0.0 3.3 2 1 1 3 3 3 1 TLD SAM_LFY PF01698.16 ETO01461.1 - 0.042 13.8 0.6 0.1 12.5 0.1 1.9 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain HrcA PF01628.21 ETO01461.1 - 1.9 8.3 9.5 3.8 7.4 9.3 1.6 1 1 0 1 1 1 0 HrcA protein C terminal domain WD40 PF00400.32 ETO01462.1 - 1.7e-05 25.5 0.1 9.8e-05 23.1 0.2 2.2 2 1 0 2 2 2 1 WD domain, G-beta repeat DEAD PF00270.29 ETO01463.1 - 1.3e-42 145.6 0.1 1.9e-42 145.0 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO01463.1 - 4.4e-31 107.5 1.5 1.4e-29 102.7 0.5 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO01463.1 - 6.9e-05 22.9 0.0 0.00014 21.9 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ETO01463.1 - 0.02 15.2 0.3 0.11 12.8 0.2 2.2 1 1 1 2 2 2 0 AAA domain CMS1 PF14617.6 ETO01463.1 - 0.06 12.7 0.0 0.16 11.3 0.0 1.7 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Flavi_DEAD PF07652.14 ETO01463.1 - 0.081 12.9 0.1 0.63 10.0 0.1 2.1 1 1 0 1 1 1 0 Flavivirus DEAD domain NACHT PF05729.12 ETO01466.1 - 0.016 15.1 0.1 0.016 15.1 0.1 1.3 1 1 0 1 1 1 0 NACHT domain FliS_cochap PF16522.5 ETO01466.1 - 0.027 14.4 0.4 0.046 13.7 0.4 1.5 1 1 0 1 1 1 0 Flagellar FLiS export co-chaperone, HP1076 HPPK PF01288.20 ETO01466.1 - 0.065 13.8 0.2 0.086 13.4 0.2 1.1 1 0 0 1 1 1 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) DUF2726 PF10881.8 ETO01468.1 - 0.073 13.0 4.7 0.045 13.6 1.5 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2726) LicD PF04991.13 ETO01468.1 - 0.1 12.7 10.1 0.13 12.4 10.1 1.1 1 0 0 1 1 1 0 LicD family Usher PF00577.20 ETO01468.1 - 0.19 10.6 0.3 0.21 10.4 0.3 1.0 1 0 0 1 1 1 0 Outer membrane usher protein MBR1 PF17058.5 ETO01468.1 - 0.35 11.2 2.7 0.43 10.9 2.7 1.1 1 0 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 DNMT1-RFD PF12047.8 ETO01469.1 - 0.025 14.6 1.7 0.058 13.4 1.3 1.8 1 1 1 2 2 2 0 Cytosine specific DNA methyltransferase replication foci domain DUF3915 PF13054.6 ETO01469.1 - 0.28 11.2 6.5 0.19 11.7 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Kelch_1 PF01344.25 ETO01472.1 - 0.014 15.0 0.6 0.099 12.2 0.2 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO01472.1 - 0.046 14.0 0.1 0.12 12.7 0.1 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_3 PF13415.6 ETO01472.1 - 0.082 13.2 0.1 0.21 11.9 0.1 1.7 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO01472.1 - 0.12 12.4 0.2 0.36 10.9 0.0 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Peroxin-22 PF12827.7 ETO01473.1 - 0.027 14.4 0.1 0.033 14.1 0.1 1.1 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family AAA_9 PF12781.7 ETO01473.1 - 0.059 12.5 0.0 0.063 12.4 0.0 1.2 1 0 0 1 1 1 0 ATP-binding dynein motor region Spc7 PF08317.11 ETO01474.1 - 0.00012 21.0 14.7 0.00012 21.0 14.7 8.7 3 3 6 9 9 9 5 Spc7 kinetochore protein GAS PF13851.6 ETO01474.1 - 0.0005 19.5 169.0 0.0074 15.7 9.3 9.5 3 3 6 9 9 9 6 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ETO01474.1 - 0.0067 16.5 17.1 0.0067 16.5 17.1 10.4 4 3 4 10 10 10 4 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SOGA PF11365.8 ETO01474.1 - 0.0071 17.5 7.8 0.0071 17.5 7.8 10.3 4 4 6 10 10 10 2 Protein SOGA DUF1192 PF06698.11 ETO01474.1 - 0.0099 15.9 1.1 0.0099 15.9 1.1 7.1 8 1 0 9 9 9 1 Protein of unknown function (DUF1192) APG6_N PF17675.1 ETO01474.1 - 0.016 15.7 18.2 0.016 15.7 18.2 10.4 2 2 7 10 10 10 0 Apg6 coiled-coil region ABC_tran PF00005.27 ETO01475.1 - 2.9e-05 24.6 0.2 0.0019 18.7 0.1 2.1 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETO01475.1 - 0.0012 18.4 0.1 0.0019 17.7 0.1 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 ETO01475.1 - 0.0022 18.3 0.1 0.04 14.2 0.1 2.2 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ETO01475.1 - 0.004 17.1 0.2 0.011 15.6 0.0 1.7 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea RsgA_GTPase PF03193.16 ETO01475.1 - 0.0049 16.8 0.1 0.0097 15.8 0.1 1.6 1 1 1 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ETO01475.1 - 0.0097 16.3 0.0 0.016 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_23 PF13476.6 ETO01475.1 - 0.016 15.7 0.6 0.016 15.7 0.6 2.2 1 1 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ETO01475.1 - 0.017 15.1 0.0 0.04 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) FTO_CTD PF12934.7 ETO01475.1 - 0.031 14.0 0.1 0.039 13.7 0.1 1.2 1 0 0 1 1 1 0 FTO C-terminal domain TsaE PF02367.17 ETO01475.1 - 0.041 13.9 0.3 0.12 12.4 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ETO01475.1 - 0.057 13.8 0.7 0.12 12.9 0.2 1.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETO01475.1 - 0.072 13.0 0.1 0.14 12.1 0.1 1.4 1 0 0 1 1 1 0 NACHT domain PduV-EutP PF10662.9 ETO01475.1 - 0.091 12.5 0.2 0.18 11.5 0.2 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_25 PF13481.6 ETO01475.1 - 0.13 11.9 0.0 0.3 10.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain Transp_Tc5_C PF04236.15 ETO01475.1 - 0.23 11.8 1.5 0.4 11.1 0.5 1.8 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain NOA36 PF06524.12 ETO01476.1 - 0.019 14.3 5.9 0.024 14.0 5.9 1.0 1 0 0 1 1 1 0 NOA36 protein SprA-related PF12118.8 ETO01476.1 - 0.041 13.0 15.0 0.044 12.9 15.0 1.0 1 0 0 1 1 1 0 SprA-related family TFIIA PF03153.13 ETO01476.1 - 0.24 11.4 19.5 0.27 11.2 19.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Paramyxo_ncap PF00973.19 ETO01476.1 - 1.1 8.1 11.6 1.2 7.9 11.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MAP17 PF15807.5 ETO01476.1 - 1.9 8.7 10.3 0.6 10.3 6.5 1.8 1 1 1 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Kei1 PF08552.11 ETO01476.1 - 2.3 8.1 5.4 3.1 7.6 5.4 1.4 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Cadherin_C_2 PF16492.5 ETO01476.1 - 2.7 8.8 6.2 7.4 7.4 6.1 2.1 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Presenilin PF01080.17 ETO01476.1 - 3.2 6.4 14.0 3.6 6.2 14.0 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO01476.1 - 4.4 6.0 10.4 4.7 5.9 10.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 ETO01476.1 - 4.6 6.7 7.4 5.6 6.4 7.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DDHD PF02862.17 ETO01476.1 - 7.5 6.6 12.7 9.2 6.4 12.7 1.1 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 ETO01476.1 - 8.1 6.4 8.6 9.9 6.1 8.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hydrolase PF00702.26 ETO01477.1 - 5.8e-07 30.0 0.0 1.8e-06 28.4 0.0 1.7 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO01477.1 - 0.12 12.7 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NACHT PF05729.12 ETO01478.1 - 1.1e-06 28.7 0.0 2.1e-06 27.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO01478.1 - 0.0013 17.9 3.1 0.0078 15.4 0.0 2.3 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 ETO01478.1 - 0.015 15.6 0.0 0.32 11.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO01478.1 - 0.049 14.0 0.0 0.13 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain SMC_N PF02463.19 ETO01478.1 - 0.21 11.0 5.5 0.77 9.1 0.0 2.5 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain LMBR1 PF04791.16 ETO01478.1 - 4.1 6.2 8.4 5.1 5.9 8.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 ETO01480.1 - 7.5e-05 23.4 1.6 0.0017 19.1 0.3 2.8 2 1 0 2 2 2 1 WD domain, G-beta repeat Kinesin PF00225.23 ETO01481.1 - 9.3e-13 47.8 4.6 1.2e-11 44.1 4.6 2.5 1 1 0 1 1 1 1 Kinesin motor domain NLRC4_HD2 PF17776.1 ETO01482.1 - 0.0025 18.4 0.1 0.012 16.2 0.0 2.2 2 0 0 2 2 2 1 NLRC4 helical domain HD2 WD40 PF00400.32 ETO01483.1 - 3.5e-10 40.3 4.8 5.8e-08 33.3 0.3 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01483.1 - 0.00091 18.0 0.1 0.0011 17.7 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 BLF1 PF17752.1 ETO01483.1 - 0.098 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Burkholderia lethal factor 1 LMBR1 PF04791.16 ETO01484.1 - 0.096 11.6 0.4 0.098 11.5 0.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3458 PF11940.8 ETO01487.1 - 3e-05 24.4 0.0 5.2e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3458) Ig-like fold DUF3458_C PF17432.2 ETO01487.1 - 4.5e-05 23.0 0.0 6.7e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 ETO01488.1 - 1.1e-11 44.7 0.0 1.4e-11 44.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ETO01489.1 - 8.1e-09 35.9 0.0 1.1e-08 35.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain DDE_Tnp_IS66 PF03050.14 ETO01489.1 - 0.2 11.1 0.0 0.27 10.7 0.0 1.1 1 0 0 1 1 1 0 Transposase IS66 family zf-TRAF PF02176.18 ETO01490.1 - 2.4e-07 31.3 1.0 2.4e-07 31.3 1.0 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger SGTA_dimer PF16546.5 ETO01490.1 - 0.034 13.9 2.2 0.77 9.6 0.1 2.6 2 1 0 2 2 2 0 Homodimerisation domain of SGTA Sina PF03145.16 ETO01490.1 - 0.088 12.7 5.6 1.6 8.7 0.5 2.8 1 1 1 3 3 3 0 Seven in absentia protein family CUE PF02845.16 ETO01493.1 - 0.034 13.8 0.1 0.056 13.2 0.1 1.4 1 0 0 1 1 1 0 CUE domain GlcNAc PF11397.8 ETO01494.1 - 2.4e-05 23.9 1.4 2.9e-05 23.7 0.1 1.7 2 0 0 2 2 2 1 Glycosyltransferase (GlcNAc) DUF3502 PF12010.8 ETO01494.1 - 0.017 15.8 1.7 0.023 15.3 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3502) DUF2063 PF09836.9 ETO01495.1 - 0.041 14.1 0.0 0.54 10.5 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain CENP-B_dimeris PF09026.10 ETO01496.1 - 0.066 13.6 0.3 1.4 9.3 0.1 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain COG4 PF08318.12 ETO01497.1 - 0.021 13.9 1.1 0.025 13.7 1.1 1.1 1 0 0 1 1 1 0 COG4 transport protein CLN3 PF02487.17 ETO01497.1 - 2.9 6.8 3.5 3.4 6.6 3.5 1.0 1 0 0 1 1 1 0 CLN3 protein WD40 PF00400.32 ETO01498.1 - 9.8e-24 83.2 18.2 3.8e-08 33.9 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01498.1 - 1.4e-08 34.9 0.1 0.038 14.3 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01498.1 - 8.1e-07 28.6 3.0 0.0055 16.1 0.4 3.1 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO01498.1 - 7.3e-06 24.9 3.5 0.011 14.5 0.4 3.0 1 1 1 3 3 3 2 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO01498.1 - 0.056 13.3 0.2 1.9 8.4 0.0 2.9 3 0 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain DUF1308 PF07000.11 ETO01500.1 - 3.6e-39 134.3 0.1 6e-38 130.4 0.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF1308) DUF4551 PF15087.6 ETO01500.1 - 0.0013 17.7 0.2 0.0013 17.7 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4551) Dicty_REP PF05086.12 ETO01500.1 - 8.4 4.2 19.5 0.041 11.9 9.2 1.9 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein AAA_18 PF13238.6 ETO01501.1 - 7.7e-06 26.5 0.9 0.00047 20.7 0.0 2.3 1 1 1 2 2 2 1 AAA domain NACHT PF05729.12 ETO01501.1 - 1.6e-05 24.9 0.0 2.8e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain TsaE PF02367.17 ETO01501.1 - 0.00082 19.4 0.0 0.0014 18.6 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 ETO01501.1 - 0.0011 19.3 0.0 0.002 18.4 0.0 1.5 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 ETO01501.1 - 0.0013 18.5 0.1 0.0032 17.2 0.0 1.6 2 0 0 2 2 2 1 Phosphoribulokinase / Uridine kinase family AAA_33 PF13671.6 ETO01501.1 - 0.0037 17.4 0.0 0.0067 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO01501.1 - 0.0057 17.0 4.2 0.034 14.5 0.1 2.6 1 1 2 3 3 3 1 RNA helicase AAA_5 PF07728.14 ETO01501.1 - 0.012 15.6 0.0 0.034 14.2 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 ETO01501.1 - 0.017 14.9 0.1 0.045 13.5 0.0 1.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATP_bind_2 PF03668.15 ETO01501.1 - 0.023 14.0 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family AAA_16 PF13191.6 ETO01501.1 - 0.023 15.1 0.0 0.069 13.5 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain Torsin PF06309.11 ETO01501.1 - 0.043 13.9 0.0 0.068 13.3 0.0 1.5 1 0 0 1 1 1 0 Torsin AAA_30 PF13604.6 ETO01501.1 - 0.053 13.2 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain VirE PF05272.11 ETO01501.1 - 0.061 13.1 0.0 0.11 12.2 0.0 1.5 1 1 0 1 1 1 0 Virulence-associated protein E ABC_tran PF00005.27 ETO01501.1 - 0.065 13.8 0.3 0.12 12.9 0.1 1.7 1 1 1 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 ETO01501.1 - 0.074 13.0 0.3 0.18 11.7 0.1 1.8 1 1 1 2 2 2 0 RsgA GTPase Sigma54_activat PF00158.26 ETO01501.1 - 0.081 12.6 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain Herpes_U44 PF04533.13 ETO01502.1 - 0.096 12.3 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 Herpes virus U44 protein Endostatin PF06482.11 ETO01503.1 - 0.29 10.6 11.0 0.38 10.2 11.0 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SAPS PF04499.15 ETO01503.1 - 0.5 9.1 14.2 0.51 9.1 14.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO01503.1 - 1.1 7.4 20.0 1.3 7.2 20.0 1.1 1 0 0 1 1 1 0 CDC45-like protein MCM_bind PF09739.9 ETO01503.1 - 1.7 7.0 17.7 1.8 6.9 17.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 ETO01503.1 - 3.7 7.3 27.2 5.3 6.8 27.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 ETO01503.1 - 4.2 4.4 14.8 4.4 4.3 14.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer VIR_N PF15912.5 ETO01503.1 - 4.7 6.7 17.7 6.2 6.3 17.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Borrelia_P83 PF05262.11 ETO01503.1 - 5.6 5.3 26.6 5.6 5.3 26.6 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein MAJIN PF15077.6 ETO01503.1 - 8.2 6.1 18.4 11 5.7 18.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein NACHT PF05729.12 ETO01504.1 - 1.7e-05 24.8 0.2 0.00019 21.4 0.2 2.3 1 1 0 1 1 1 1 NACHT domain ABC2_membrane PF01061.24 ETO01505.1 - 3e-32 111.7 19.7 2.2e-27 95.9 9.9 2.2 2 0 0 2 2 2 2 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO01505.1 - 2.4e-05 23.6 19.2 7.2e-05 22.0 18.6 1.9 1 1 0 1 1 1 1 ABC-2 family transporter protein SPC12 PF06645.13 ETO01505.1 - 0.13 12.3 4.0 0.8 9.8 0.4 2.8 2 0 0 2 2 2 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF4485 PF14846.6 ETO01507.1 - 0.037 14.1 0.0 0.077 13.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) DUF2085 PF09858.9 ETO01508.1 - 0.033 14.6 0.0 0.052 14.0 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2085) HTH_40 PF14493.6 ETO01508.1 - 0.092 13.2 0.2 0.14 12.6 0.2 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain WD40 PF00400.32 ETO01509.1 - 1.6e-18 66.7 13.2 1.9e-06 28.5 0.3 4.7 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01509.1 - 0.0072 16.6 1.3 9.6 6.6 0.1 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01509.1 - 0.047 12.3 0.4 4.1 5.9 0.0 2.7 2 1 0 3 3 3 0 Nucleoporin Nup120/160 Peptidase_C14 PF00656.22 ETO01511.1 - 0.00015 21.8 0.1 0.00023 21.2 0.1 1.2 1 0 0 1 1 1 1 Caspase domain SHE3 PF17078.5 ETO01511.1 - 0.064 13.0 0.3 0.12 12.0 0.3 1.4 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 RPAP3_C PF13877.6 ETO01512.1 - 0.12 12.9 0.4 0.27 11.8 0.4 1.5 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 WD40 PF00400.32 ETO01515.1 - 9e-37 124.4 14.0 3.1e-11 43.6 0.2 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01515.1 - 5.2e-18 65.1 0.1 9.5e-05 22.6 0.0 4.8 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO01515.1 - 9.3e-08 31.4 0.1 0.014 14.4 0.1 3.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 ETO01515.1 - 3e-06 27.0 0.0 0.0095 15.5 0.0 2.3 1 1 1 2 2 2 2 PQQ-like domain DUF727 PF05303.12 ETO01515.1 - 1.6e-05 24.9 0.1 0.78 9.8 0.0 3.4 1 1 2 3 3 3 2 Protein of unknown function (DUF727) WD40_like PF17005.5 ETO01515.1 - 0.00012 21.5 0.3 0.11 11.8 0.1 2.3 2 0 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO01515.1 - 0.0014 18.6 1.1 5.4 7.1 0.0 3.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO01515.1 - 0.0044 17.1 3.3 5.7 7.0 0.2 4.1 1 1 4 5 5 5 1 Family of unknown function (DUF5570) Frtz PF11768.8 ETO01515.1 - 0.0082 14.5 0.0 3.1 6.0 0.0 2.6 2 1 0 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz WXG100 PF06013.12 ETO01515.1 - 0.0094 16.2 0.0 21 5.4 0.0 3.1 3 0 0 3 3 3 0 Proteins of 100 residues with WXG Cytochrom_D1 PF02239.16 ETO01515.1 - 0.0099 14.4 0.1 0.82 8.1 0.0 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO01515.1 - 0.015 15.2 0.0 22 5.2 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat DUF5643 PF18705.1 ETO01515.1 - 0.016 15.2 0.1 9.2 6.3 0.0 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5643) Peptidase_C9 PF01707.16 ETO01515.1 - 0.054 13.1 0.0 17 5.0 0.0 3.0 2 1 1 3 3 3 0 Peptidase family C9 FPL PF09758.9 ETO01516.1 - 0.032 14.2 0.4 0.043 13.8 0.4 1.1 1 0 0 1 1 1 0 Uncharacterised conserved protein OPA3 PF07047.12 ETO01516.1 - 0.17 11.7 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 Optic atrophy 3 protein (OPA3) TPR_12 PF13424.6 ETO01517.1 - 0.00012 22.3 0.0 0.00022 21.5 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01517.1 - 0.00048 19.9 0.1 0.001 18.9 0.0 1.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01517.1 - 0.0019 18.2 0.0 0.0062 16.6 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01517.1 - 0.0063 16.6 0.1 0.019 15.1 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01517.1 - 0.016 15.0 0.3 0.05 13.4 0.3 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat s48_45 PF07422.13 ETO01517.1 - 0.49 11.0 8.1 0.89 10.2 8.1 1.6 1 1 0 1 1 1 0 Sexual stage antigen s48/45 domain INTS5_N PF14837.6 ETO01518.1 - 0.095 12.3 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Integrator complex subunit 5 N-terminus CENP-B_dimeris PF09026.10 ETO01518.1 - 2.2 8.7 18.8 0.081 13.3 9.4 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Importin_rep_4 PF18808.1 ETO01518.1 - 2.3 8.6 8.3 1 9.7 6.0 1.5 1 1 1 2 2 2 0 Importin repeat DUF1754 PF08555.10 ETO01518.1 - 4.2 8.2 16.8 3.8 8.4 1.0 2.3 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Cytomega_UL84 PF06284.11 ETO01518.1 - 5.9 5.2 6.4 9.4 4.6 6.4 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF4407 PF14362.6 ETO01518.1 - 7.8 5.8 8.0 10 5.4 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2540 PF10802.8 ETO01519.1 - 0.017 15.2 0.4 0.025 14.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2540) UQ_con PF00179.26 ETO01520.1 - 3.9e-07 29.8 1.4 5.3e-07 29.4 1.2 1.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETO01520.1 - 6.9e-05 23.1 0.1 9.5e-05 22.7 0.1 1.2 1 0 0 1 1 1 1 RWD domain Prok-E2_B PF14461.6 ETO01520.1 - 0.0023 17.6 0.0 0.0032 17.2 0.0 1.3 1 1 0 1 1 1 1 Prokaryotic E2 family B UEV PF05743.13 ETO01520.1 - 0.0075 16.1 0.1 0.012 15.5 0.1 1.3 1 0 0 1 1 1 1 UEV domain WD40 PF00400.32 ETO01521.1 - 6.5e-10 39.4 8.9 1.2e-07 32.3 2.0 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01521.1 - 0.0022 16.7 0.1 0.0025 16.6 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO01521.1 - 0.0091 15.4 0.4 0.014 14.8 0.4 1.2 1 0 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO01521.1 - 0.011 16.0 0.0 0.021 15.1 0.0 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4403 PF14356.6 ETO01523.1 - 0.022 13.4 5.0 0.028 13.1 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4403) XRN_M PF17846.1 ETO01523.1 - 0.034 13.1 5.1 0.035 13.1 5.1 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF4770 PF15994.5 ETO01523.1 - 0.041 14.1 7.0 0.058 13.6 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Auxin_canalis PF05703.11 ETO01523.1 - 2.6 7.9 8.9 3.2 7.6 8.9 1.1 1 0 0 1 1 1 0 Auxin canalisation E7 PF00527.18 ETO01523.1 - 7.4 6.8 8.9 0.55 10.5 0.8 2.5 2 1 0 3 3 3 0 E7 protein, Early protein Protoglobin PF11563.8 ETO01524.1 - 0.013 15.5 0.2 0.018 15.0 0.2 1.2 1 0 0 1 1 1 0 Protoglobin MIEAP PF16026.5 ETO01524.1 - 0.013 15.8 0.1 0.036 14.3 0.1 1.8 1 1 0 1 1 1 0 Mitochondria-eating protein Nodulin_late PF07127.11 ETO01525.1 - 0.2 12.1 5.3 0.3 11.4 1.3 2.4 2 0 0 2 2 2 0 Late nodulin protein WD40 PF00400.32 ETO01527.1 - 2e-30 104.4 25.7 1.5e-05 25.7 1.2 7.6 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01527.1 - 8.1e-13 48.5 3.9 0.00043 20.5 0.1 5.9 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01527.1 - 1.1e-10 40.8 12.9 0.0028 16.4 0.5 4.9 1 1 3 4 4 4 4 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO01527.1 - 0.019 15.2 2.7 0.23 11.7 0.5 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) ABC_tran PF00005.27 ETO01528.1 - 1.7e-12 48.0 0.0 3e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO01528.1 - 0.00086 19.2 0.1 0.0011 18.8 0.1 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ETO01528.1 - 0.0053 17.0 0.2 0.16 12.2 0.2 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ETO01528.1 - 0.012 15.1 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain KDGP_aldolase PF07071.11 ETO01528.1 - 0.15 11.8 0.0 0.19 11.5 0.0 1.1 1 0 0 1 1 1 0 KDGP aldolase VWA PF00092.28 ETO01529.1 - 8.9e-05 22.8 0.1 0.00073 19.8 0.0 2.4 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO01529.1 - 0.00019 22.0 0.0 0.00047 20.8 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain Helicase_C PF00271.31 ETO01529.1 - 0.00037 20.8 0.2 0.0023 18.3 0.1 2.5 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DUF1330 PF07045.11 ETO01529.1 - 0.12 12.7 0.1 0.4 11.1 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) FAM176 PF14851.6 ETO01530.1 - 0.06 13.0 0.4 0.13 11.9 0.4 1.6 1 0 0 1 1 1 0 FAM176 family DUF2098 PF09871.9 ETO01530.1 - 2.2 8.7 5.3 4.7 7.6 5.2 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Ly49 PF08391.10 ETO01531.1 - 3.9 7.9 10.0 4.3 7.7 10.0 1.1 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region LptF_LptG PF03739.14 ETO01531.1 - 4.8 5.9 4.9 4.7 5.9 4.9 1.0 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG SNF2_assoc PF08455.10 ETO01534.1 - 0.049 12.7 1.5 0.058 12.4 1.5 1.2 1 0 0 1 1 1 0 Bacterial SNF2 helicase associated Kelch_4 PF13418.6 ETO01535.1 - 0.0011 18.9 0.5 0.0093 16.0 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01535.1 - 0.083 12.5 1.7 2.5 7.8 0.2 3.2 3 0 0 3 3 3 0 Kelch motif PIP5K PF01504.18 ETO01537.1 - 1.1e-33 116.7 0.0 1.1e-33 116.7 0.0 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase RP-C_C PF11800.8 ETO01537.1 - 0.056 13.5 1.8 0.076 13.1 1.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region VAD1-2 PF15310.6 ETO01537.1 - 0.13 12.2 3.8 0.17 11.8 3.8 1.2 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling DNA_pol_phi PF04931.13 ETO01537.1 - 0.21 9.6 4.7 0.3 9.1 4.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF913 PF06025.12 ETO01537.1 - 0.25 10.3 1.4 0.4 9.6 1.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO01537.1 - 0.27 10.0 4.0 0.33 9.7 4.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ribosomal_L6e PF01159.19 ETO01537.1 - 0.29 11.7 4.7 0.71 10.4 3.8 1.9 2 0 0 2 2 2 0 Ribosomal protein L6e DUF4637 PF15470.6 ETO01537.1 - 0.44 10.3 4.6 0.66 9.7 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PPL5 PF18168.1 ETO01537.1 - 5.1 6.3 9.8 11 5.2 0.0 2.1 2 0 0 2 2 2 0 Prim-pol family 5 TPR_12 PF13424.6 ETO01538.1 - 1.3e-11 44.6 0.1 5.2e-11 42.7 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01538.1 - 6.1e-10 38.5 2.6 5.3e-08 32.4 1.4 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01538.1 - 6.6e-08 32.2 1.5 1.5e-07 31.1 0.5 2.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01538.1 - 2.4e-07 30.3 0.4 1.8e-06 27.6 0.2 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01538.1 - 6.3e-06 25.9 0.9 5.5e-05 23.0 0.6 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01538.1 - 2.1e-05 24.2 0.6 0.00039 20.2 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO01538.1 - 0.00043 20.2 1.4 0.087 12.8 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01538.1 - 0.00044 20.7 0.9 0.0015 19.0 0.4 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO01538.1 - 0.00086 19.5 0.4 0.0058 16.8 0.2 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETO01538.1 - 0.0012 18.5 4.4 0.0096 15.6 2.0 3.0 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO01538.1 - 0.0029 17.9 0.3 0.025 14.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01538.1 - 0.0047 17.5 0.0 0.027 15.1 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01538.1 - 0.007 17.1 0.1 0.026 15.3 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2521 PF10730.9 ETO01538.1 - 0.044 13.8 0.0 0.046 13.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2521) Ubiq-assoc PF09145.10 ETO01538.1 - 0.056 13.4 1.9 6.3 6.9 0.1 2.4 2 0 0 2 2 2 0 Ubiquitin-associated PPR PF01535.20 ETO01538.1 - 0.17 12.2 0.7 6.7 7.2 0.0 2.9 3 0 0 3 3 3 0 PPR repeat MIT PF04212.18 ETO01538.1 - 0.22 11.6 1.6 2 8.6 1.1 2.2 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain YnfE PF17452.2 ETO01539.1 - 0.63 10.4 6.5 0.45 10.8 0.9 2.8 1 1 1 2 2 2 0 Uncharacterized YnfE-like CDC45 PF02724.14 ETO01541.1 - 2.3 6.4 12.4 2.8 6.1 12.4 1.2 1 0 0 1 1 1 0 CDC45-like protein ThiJ_like PF17124.5 ETO01542.1 - 0.03 14.0 0.0 0.035 13.8 0.0 1.1 1 0 0 1 1 1 0 ThiJ/PfpI family-like BspA_v PF18220.1 ETO01542.1 - 0.053 13.6 1.9 0.065 13.4 1.9 1.3 1 1 0 1 1 1 0 Adhesin BspA variable domain ACP_PD PF04336.12 ETO01542.1 - 0.074 13.5 0.0 0.097 13.1 0.0 1.3 1 0 0 1 1 1 0 Acyl carrier protein phosphodiesterase DUF3989 PF13150.6 ETO01542.1 - 0.098 12.4 1.7 6.3 6.6 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3989) PBP_sp32 PF07222.12 ETO01543.1 - 0.25 10.8 4.7 0.31 10.5 4.7 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 O-FucT PF10250.9 ETO01545.1 - 0.00053 19.8 6.5 0.0026 17.5 0.1 3.1 2 1 1 3 3 3 2 GDP-fucose protein O-fucosyltransferase DUF1031 PF06275.11 ETO01545.1 - 0.054 13.8 0.2 0.2 11.9 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1031) Exo_endo_phos PF03372.23 ETO01546.1 - 1.5e-11 44.3 0.0 5.6e-11 42.4 0.0 1.9 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family PMI_typeI PF01238.21 ETO01547.1 - 4.7e-50 170.8 1.1 1.1e-49 169.6 1.1 1.5 1 1 0 1 1 1 1 Phosphomannose isomerase type I HCO3_cotransp PF00955.21 ETO01548.1 - 0.076 11.8 5.2 0.084 11.7 5.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family MAP17 PF15807.5 ETO01548.1 - 0.077 13.2 7.0 0.051 13.8 5.6 1.4 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SID-1_RNA_chan PF13965.6 ETO01548.1 - 0.077 11.4 5.7 0.087 11.2 5.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 ETO01548.1 - 0.21 10.8 3.8 0.23 10.6 3.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 ETO01548.1 - 0.25 10.3 4.0 0.28 10.2 4.0 1.1 1 0 0 1 1 1 0 CLN3 protein YbgS PF13985.6 ETO01548.1 - 9.5 6.5 8.4 4 7.7 5.9 1.6 1 1 1 2 2 2 0 YbgS-like protein PARG_cat PF05028.14 ETO01550.1 - 1.2e-13 51.1 0.0 1.3e-13 51.0 0.0 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) FAA_hydrolase PF01557.18 ETO01553.1 - 4.7e-08 33.0 0.0 5.2e-08 32.8 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family CAP_GLY PF01302.25 ETO01555.1 - 0.065 13.3 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 CAP-Gly domain COMM_domain PF07258.14 ETO01556.1 - 2.5e-14 53.1 0.1 3.1e-14 52.8 0.1 1.1 1 0 0 1 1 1 1 COMM domain CAC1F_C PF16885.5 ETO01557.1 - 2.1 8.0 12.2 2.2 7.9 12.2 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Presenilin PF01080.17 ETO01558.1 - 0.00052 18.9 9.0 0.00052 18.9 9.0 3.1 2 1 0 2 2 2 1 Presenilin GBP_C PF02841.14 ETO01558.1 - 0.0043 16.5 11.7 0.0043 16.5 11.7 3.6 3 0 0 3 3 3 1 Guanylate-binding protein, C-terminal domain OmpH PF03938.14 ETO01558.1 - 0.0082 16.5 17.8 0.0082 16.5 17.8 4.2 4 1 0 4 4 4 1 Outer membrane protein (OmpH-like) Nup54 PF13874.6 ETO01558.1 - 0.068 13.3 17.9 0.077 13.1 1.2 2.7 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Zip PF02535.22 ETO01558.1 - 0.2 10.8 15.6 12 5.0 0.0 3.1 2 1 0 2 2 2 0 ZIP Zinc transporter DUF948 PF06103.11 ETO01558.1 - 7.9 6.8 13.3 2.4 8.5 4.3 3.7 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF2369 PF10179.9 ETO01562.1 - 0.013 15.8 0.0 0.02 15.3 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Folate_carrier PF01770.18 ETO01563.1 - 0.023 13.4 4.7 0.029 13.1 4.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF3584 PF12128.8 ETO01567.1 - 4.8e-06 24.4 37.1 6.1e-06 24.1 37.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF1385 PF07136.11 ETO01567.1 - 0.085 12.1 0.1 0.18 11.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1385) RNA_pol_Rpb5_C PF01191.19 ETO01567.1 - 0.13 12.2 4.4 0.19 11.6 0.0 3.4 3 0 0 3 3 3 0 RNA polymerase Rpb5, C-terminal domain Mod_r PF07200.13 ETO01567.1 - 0.44 10.6 53.5 0.041 14.0 17.6 4.1 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF948 PF06103.11 ETO01567.1 - 0.87 9.9 12.0 26 5.1 2.0 3.5 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) KASH_CCD PF14662.6 ETO01567.1 - 1.4 8.7 62.5 20 5.0 21.7 4.3 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.7 ETO01567.1 - 9.2 6.4 64.5 7.5 6.7 27.9 2.8 1 1 1 2 2 2 0 Tropomyosin like EF-hand_13 PF17958.1 ETO01568.1 - 0.073 12.9 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain AIF_C PF14721.6 ETO01570.1 - 1 9.7 7.5 1.3 9.4 7.5 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Connexin PF00029.19 ETO01570.1 - 2.7 7.7 6.6 3 7.6 6.6 1.1 1 0 0 1 1 1 0 Connexin Met_synt_B12 PF02965.17 ETO01574.1 - 0.0098 15.4 0.4 0.011 15.2 0.4 1.1 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain DUF494 PF04361.13 ETO01575.1 - 0.0071 16.3 0.9 0.046 13.6 0.3 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF494) Pox_A_type_inc PF04508.12 ETO01575.1 - 0.025 14.4 1.2 0.036 13.9 0.1 1.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat VSG_B PF13206.6 ETO01575.1 - 0.39 9.9 9.6 0.56 9.4 9.6 1.2 1 0 0 1 1 1 0 Trypanosomal VSG domain Apis_Csd PF11671.8 ETO01575.1 - 1.2 9.2 8.0 0.059 13.4 0.7 2.0 2 0 0 2 2 2 0 Complementary sex determiner protein CRAL_TRIO PF00650.20 ETO01576.1 - 1.7e-22 79.9 0.3 2e-22 79.6 0.3 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ETO01576.1 - 4.3e-05 23.7 0.5 5.6e-05 23.3 0.5 1.1 1 0 0 1 1 1 1 Divergent CRAL/TRIO domain PDR_CDR PF06422.12 ETO01576.1 - 0.053 13.4 0.4 0.11 12.4 0.4 1.4 1 0 0 1 1 1 0 CDR ABC transporter Aldo_ket_red PF00248.21 ETO01578.1 - 5.5e-52 176.8 0.0 7.1e-52 176.4 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family La PF05383.17 ETO01580.1 - 4.2e-10 39.5 0.5 4.2e-10 39.5 0.5 2.5 2 1 1 3 3 3 1 La domain XPC-binding PF09280.11 ETO01582.1 - 0.0038 16.9 0.2 0.015 15.0 0.1 1.8 2 0 0 2 2 2 1 XPC-binding domain RasGAP_C PF03836.15 ETO01582.1 - 0.019 15.1 2.9 0.024 14.8 2.9 1.1 1 0 0 1 1 1 0 RasGAP C-terminus MCM_N PF14551.6 ETO01582.1 - 0.039 14.6 1.7 0.054 14.1 1.7 1.3 1 0 0 1 1 1 0 MCM N-terminal domain Complex1_49kDa PF00346.19 ETO01582.1 - 0.18 10.9 1.6 0.19 10.8 1.6 1.1 1 0 0 1 1 1 0 Respiratory-chain NADH dehydrogenase, 49 Kd subunit MRPL52 PF18699.1 ETO01582.1 - 2.1 8.6 7.7 0.86 9.8 4.1 1.9 1 1 2 3 3 3 0 Mitoribosomal protein mL52 WD40 PF00400.32 ETO01584.1 - 1.6e-17 63.5 7.5 4.2e-05 24.2 0.2 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO01584.1 - 7.6e-06 24.8 2.1 0.29 9.7 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01584.1 - 0.00082 19.6 0.3 0.63 10.4 0.0 3.0 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01584.1 - 0.0059 16.0 2.0 0.078 12.3 0.3 2.4 1 1 1 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETO01584.1 - 0.0083 16.0 0.1 1.8 8.4 0.1 2.7 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A DUF4979 PF16351.5 ETO01584.1 - 0.025 14.8 0.9 13 6.0 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) Ribosomal_S8e PF01201.22 ETO01585.1 - 5e-50 169.2 0.7 1.4e-49 167.7 0.7 1.6 1 1 0 1 1 1 1 Ribosomal protein S8e IL12p40_C PF10420.9 ETO01587.1 - 0.018 15.5 4.0 0.72 10.4 0.1 2.5 2 1 1 3 3 3 0 Cytokine interleukin-12p40 C-terminus PUB PF09409.10 ETO01588.1 - 0.0048 16.8 2.4 0.026 14.4 2.4 2.1 1 1 0 1 1 1 1 PUB domain Actin PF00022.19 ETO01589.1 - 8.2e-15 54.3 0.1 1e-14 54.0 0.1 1.4 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO01589.1 - 0.22 10.3 0.0 0.35 9.7 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein DUF3774 PF12609.8 ETO01589.1 - 0.69 11.0 3.5 5.3 8.1 0.3 2.5 1 1 1 2 2 2 0 Wound-induced protein Peptidase_S8_N PF16361.5 ETO01591.1 - 0.06 13.8 1.6 0.089 13.3 1.6 1.4 1 1 0 1 1 1 0 N-terminal of Subtilase family DUF3510 PF12022.8 ETO01591.1 - 0.062 13.7 0.7 0.099 13.0 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) TPR_12 PF13424.6 ETO01596.1 - 0.0055 17.0 7.6 0.0061 16.8 0.6 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01596.1 - 0.0068 16.5 0.9 0.0068 16.5 0.9 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat DUF3584 PF12128.8 ETO01596.1 - 0.015 12.9 18.4 0.019 12.5 18.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_2 PF07719.17 ETO01596.1 - 0.024 14.7 14.2 0.14 12.3 0.9 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat YlqD PF11068.8 ETO01596.1 - 0.039 14.3 10.0 0.039 14.3 10.0 2.4 1 1 1 2 2 2 0 YlqD protein FapA PF03961.13 ETO01596.1 - 0.15 10.6 10.4 0.18 10.4 10.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Phage_GPO PF05929.11 ETO01596.1 - 0.16 11.6 11.5 0.21 11.2 11.5 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase TPR_1 PF00515.28 ETO01596.1 - 0.17 11.8 9.8 1.1 9.1 2.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM76 PF16046.5 ETO01596.1 - 0.22 10.8 14.1 0.27 10.5 14.1 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 ETO01596.1 - 0.53 9.6 8.8 0.71 9.2 8.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cob_adeno_trans PF01923.18 ETO01596.1 - 1.6 8.8 8.1 1.6 8.8 4.5 2.0 1 1 1 2 2 2 0 Cobalamin adenosyltransferase TPR_11 PF13414.6 ETO01596.1 - 2 8.2 10.6 0.069 12.8 2.3 2.7 2 1 1 3 3 3 0 TPR repeat Phage_Mu_Gam PF07352.12 ETO01596.1 - 4.1 7.3 15.9 2.6 8.0 11.2 2.4 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein YL1 PF05764.13 ETO01597.1 - 0.00053 20.2 7.6 0.0006 20.0 7.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein NPR3 PF03666.13 ETO01597.1 - 0.017 14.0 1.2 0.018 13.9 1.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 eIF-3c_N PF05470.12 ETO01597.1 - 0.26 9.6 11.1 0.31 9.3 11.1 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2151 PF10221.9 ETO01597.1 - 0.28 9.7 6.6 0.32 9.5 6.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Spt5_N PF11942.8 ETO01597.1 - 0.42 11.6 14.7 0.58 11.2 14.7 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Zip PF02535.22 ETO01597.1 - 0.52 9.5 7.3 0.22 10.7 3.0 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter SDA1 PF05285.12 ETO01597.1 - 0.61 9.5 17.7 0.77 9.1 17.7 1.0 1 0 0 1 1 1 0 SDA1 XAP5 PF04921.14 ETO01597.1 - 0.71 9.7 10.6 1 9.1 10.6 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator EFTUD2 PF16004.5 ETO01597.1 - 1.2 9.8 13.4 1.6 9.3 13.4 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus CPSF100_C PF13299.6 ETO01597.1 - 1.4 9.0 6.7 2 8.6 6.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 ETO01597.1 - 2.2 7.0 7.8 3 6.5 7.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.16 ETO01597.1 - 2.3 7.4 10.3 3 7.0 10.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 ETO01597.1 - 3 6.5 6.0 3.7 6.2 6.0 1.1 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 ETO01597.1 - 3.2 7.1 16.7 4.5 6.6 16.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Roughex PF06020.11 ETO01597.1 - 3.2 6.8 10.4 4.9 6.2 10.4 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Nop14 PF04147.12 ETO01597.1 - 5.1 5.2 16.1 6.2 4.9 16.1 1.0 1 0 0 1 1 1 0 Nop14-like family PTPRCAP PF15713.5 ETO01597.1 - 5.2 7.4 13.6 7.2 6.9 13.6 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DNA_pol_phi PF04931.13 ETO01597.1 - 8.1 4.4 15.4 10 4.1 15.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Menin PF05053.13 ETO01598.1 - 0.0026 16.2 4.8 0.0028 16.1 4.8 1.1 1 0 0 1 1 1 1 Menin Cwf_Cwc_15 PF04889.12 ETO01598.1 - 0.003 17.4 13.2 0.0035 17.1 13.2 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Spt20 PF12090.8 ETO01598.1 - 0.0044 16.7 12.7 0.006 16.2 12.7 1.3 1 0 0 1 1 1 1 Spt20 family Zip PF02535.22 ETO01598.1 - 0.012 14.9 4.0 0.013 14.8 4.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ETO01598.1 - 0.015 15.2 7.2 0.016 15.0 7.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ETO01598.1 - 0.022 13.7 2.8 0.025 13.6 2.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.12 ETO01598.1 - 0.035 12.3 11.8 0.035 12.3 11.8 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 ETO01598.1 - 0.042 14.2 11.5 0.055 13.8 11.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NOA36 PF06524.12 ETO01598.1 - 0.044 13.1 14.5 0.055 12.8 14.5 1.1 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETO01598.1 - 0.12 12.0 12.5 0.15 11.7 12.5 1.2 1 0 0 1 1 1 0 PPP4R2 Suf PF05843.14 ETO01598.1 - 0.14 12.2 4.3 0.15 12.0 4.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SAPS PF04499.15 ETO01598.1 - 0.16 10.8 9.4 0.16 10.7 9.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Pox_Ag35 PF03286.14 ETO01598.1 - 0.19 11.5 11.3 0.29 10.9 11.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Raftlin PF15250.6 ETO01598.1 - 0.21 10.3 5.8 0.26 10.0 5.8 1.1 1 0 0 1 1 1 0 Raftlin CDC45 PF02724.14 ETO01598.1 - 0.26 9.5 13.5 0.35 9.1 13.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Serinc PF03348.15 ETO01598.1 - 0.38 9.6 3.2 0.47 9.3 3.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM60A PF15396.6 ETO01598.1 - 0.39 10.7 6.2 0.46 10.5 6.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ETO01598.1 - 0.42 9.3 10.8 0.5 9.1 10.8 1.1 1 0 0 1 1 1 0 Presenilin DUF2370 PF10176.9 ETO01598.1 - 0.5 10.0 3.7 0.76 9.4 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SpoIIIAH PF12685.7 ETO01598.1 - 0.78 9.5 13.4 1.3 8.8 13.4 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein ALMT PF11744.8 ETO01598.1 - 1 8.1 3.5 1.1 8.1 3.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RRN3 PF05327.11 ETO01598.1 - 1.1 7.8 10.3 1.5 7.3 10.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SLC12 PF03522.15 ETO01598.1 - 1.3 7.9 9.8 1.6 7.7 9.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 ETO01598.1 - 1.6 6.8 8.6 1.6 6.7 8.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Paramyxo_ncap PF00973.19 ETO01598.1 - 1.6 7.6 7.1 1.7 7.5 7.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Neur_chan_memb PF02932.16 ETO01598.1 - 1.8 8.5 5.9 2.1 8.3 5.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sporozoite_P67 PF05642.11 ETO01598.1 - 3.1 5.8 15.7 4.2 5.3 15.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PGA2 PF07543.12 ETO01598.1 - 3.4 7.6 13.0 5.1 7.1 13.0 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF4820 PF16091.5 ETO01598.1 - 9.3 5.5 12.8 16 4.7 12.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) Peptidase_C14 PF00656.22 ETO01599.1 - 4.1e-05 23.7 0.8 0.00013 22.0 0.8 1.7 1 1 0 1 1 1 1 Caspase domain TPR_12 PF13424.6 ETO01600.1 - 7.5e-27 93.4 1.5 3.3e-15 56.1 0.6 3.2 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01600.1 - 3.6e-26 89.9 22.4 6.1e-09 35.3 4.0 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01600.1 - 8.9e-21 72.3 14.6 4.9e-07 29.4 1.2 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01600.1 - 4.4e-20 70.2 19.8 9.9e-07 28.5 3.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01600.1 - 1e-19 69.7 0.0 1.4e-06 28.0 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01600.1 - 2.8e-19 67.7 1.8 1.6e-05 24.6 0.0 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO01600.1 - 6.6e-11 42.6 0.6 1.4e-10 41.5 0.6 1.5 1 0 0 1 1 1 1 Caspase domain TPR_11 PF13414.6 ETO01600.1 - 8.7e-08 31.7 13.2 0.003 17.2 1.5 5.3 4 1 1 5 5 5 3 TPR repeat TPR_6 PF13174.6 ETO01600.1 - 1.5e-05 25.3 7.3 0.046 14.4 0.2 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01600.1 - 3.9e-05 24.2 0.1 9.1 7.0 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO01600.1 - 0.0013 18.3 8.3 0.0027 17.2 1.5 3.1 3 1 1 4 4 4 2 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 ETO01600.1 - 0.0032 18.2 0.0 37 5.5 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO01600.1 - 0.025 14.6 9.3 3 7.9 2.1 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01600.1 - 0.062 13.7 12.3 9.7 6.8 2.9 4.7 4 1 0 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO01600.1 - 0.2 11.1 1.1 29 4.2 0.0 3.6 4 0 0 4 4 4 0 SHNi-TPR TPR_19 PF14559.6 ETO01600.1 - 0.21 12.1 0.5 3.6 8.2 0.3 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETO01600.1 - 0.23 11.6 10.1 4.9 7.3 0.0 4.3 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain HTH_Bact PF18768.1 ETO01600.1 - 0.3 10.7 6.1 0.53 9.9 0.2 3.4 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain ANAPC3 PF12895.7 ETO01600.1 - 0.63 10.3 8.2 3.3 8.0 1.4 3.4 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Spore_GerAC PF05504.11 ETO01600.1 - 9.7 6.4 18.8 3.2 8.0 4.6 3.4 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal NST1 PF13945.6 ETO01601.1 - 3.7 7.6 22.9 0.3 11.2 9.1 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator PI3_PI4_kinase PF00454.27 ETO01602.1 - 4.8e-08 33.1 0.0 7.2e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PDR_CDR PF06422.12 ETO01602.1 - 0.012 15.5 0.5 0.019 14.8 0.5 1.3 1 0 0 1 1 1 0 CDR ABC transporter zf-RanBP PF00641.18 ETO01605.1 - 9e-06 24.9 5.0 9e-06 24.9 5.0 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others TssO PF17561.2 ETO01605.1 - 0.0051 16.9 7.5 0.011 15.9 7.5 1.5 1 0 0 1 1 1 1 Type VI secretion system, TssO CrgA PF06781.12 ETO01605.1 - 0.036 14.1 0.0 0.071 13.2 0.0 1.5 1 0 0 1 1 1 0 Cell division protein CrgA NACHT PF05729.12 ETO01607.1 - 0.054 13.4 0.0 0.054 13.4 0.0 1.1 1 0 0 1 1 1 0 NACHT domain DUF5436 PF17504.2 ETO01608.1 - 0.0052 17.1 0.8 0.061 13.6 0.0 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5436) DUF2490 PF10677.9 ETO01608.1 - 0.042 13.8 0.0 0.053 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2490) HSP70 PF00012.20 ETO01609.1 - 5.5e-47 160.3 0.4 2.1e-31 108.8 0.7 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO01609.1 - 4.7e-10 38.8 0.6 6.2e-10 38.4 0.6 1.3 1 1 0 1 1 1 1 MreB/Mbl protein MRG PF05712.13 ETO01609.1 - 0.019 14.3 0.2 0.057 12.7 0.1 1.7 1 1 1 2 2 2 0 MRG MMR_HSR1 PF01926.23 ETO01610.1 - 1.6e-11 44.3 0.8 2.8e-11 43.5 0.1 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO01610.1 - 4.1e-05 23.6 1.0 7.6e-05 22.7 0.3 1.7 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 ETO01610.1 - 6e-05 23.6 0.6 0.00031 21.3 0.1 2.1 2 0 0 2 2 2 1 ABC transporter AIG1 PF04548.16 ETO01610.1 - 0.00051 19.4 0.2 0.00097 18.5 0.2 1.5 1 0 0 1 1 1 1 AIG1 family FeoB_N PF02421.18 ETO01610.1 - 0.00093 18.7 0.2 0.0016 18.0 0.2 1.3 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 ETO01610.1 - 0.0035 17.6 1.8 0.018 15.2 1.8 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 ETO01610.1 - 0.0045 16.2 0.0 0.0076 15.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ETO01610.1 - 0.0051 16.5 0.1 0.012 15.3 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 ETO01610.1 - 0.01 15.9 1.0 0.08 13.0 1.2 2.2 1 1 1 2 2 2 0 Dynamin family AAA_16 PF13191.6 ETO01610.1 - 0.061 13.7 0.0 0.095 13.1 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ETO01610.1 - 0.072 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.18 ETO01610.1 - 0.077 12.3 0.1 0.18 11.1 0.1 1.6 1 0 0 1 1 1 0 Septin AAA_21 PF13304.6 ETO01610.1 - 0.094 12.5 0.1 0.15 11.9 0.1 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ETO01610.1 - 0.097 13.0 0.1 0.2 11.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ETO01610.1 - 0.17 11.7 0.8 0.75 9.5 0.8 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 ETO01610.1 - 0.17 12.3 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ETO01610.1 - 2.6 8.5 6.8 12 6.3 6.4 2.3 1 1 1 2 2 2 0 AAA domain RRM_1 PF00076.22 ETO01611.1 - 9.3e-15 54.2 0.0 3.3e-06 26.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MepB PF08877.10 ETO01611.1 - 0.038 13.7 0.7 0.59 9.8 0.0 2.5 2 0 0 2 2 2 0 MepB protein Flavi_NS1 PF00948.21 ETO01611.1 - 0.1 11.5 0.1 0.14 11.0 0.1 1.2 1 0 0 1 1 1 0 Flavivirus non-structural Protein NS1 Kelch_2 PF07646.15 ETO01615.1 - 8.3e-07 28.8 0.1 0.0024 17.8 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO01615.1 - 4.9e-06 26.6 0.3 0.014 15.7 0.3 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO01615.1 - 1.3e-05 25.1 0.2 0.034 14.1 0.1 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01615.1 - 3e-05 23.5 0.2 0.0028 17.2 0.3 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO01615.1 - 0.00012 22.2 0.1 0.008 16.5 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01615.1 - 0.0019 18.2 0.2 0.15 12.1 0.5 2.3 2 0 0 2 2 2 1 Kelch motif Peptidase_M48 PF01435.18 ETO01616.1 - 1.9e-26 93.0 0.6 5.5e-26 91.6 0.6 1.8 1 0 0 1 1 1 1 Peptidase family M48 Thioredoxin_4 PF13462.6 ETO01616.1 - 6.5e-23 81.7 1.0 5e-22 78.8 0.0 3.0 3 0 0 3 3 3 1 Thioredoxin DSBA PF01323.20 ETO01616.1 - 8.2e-20 71.4 0.0 1.5e-18 67.3 0.0 2.6 1 1 0 1 1 1 1 DSBA-like thioredoxin domain TPR_19 PF14559.6 ETO01616.1 - 1.9e-06 28.3 0.4 0.021 15.3 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01616.1 - 2.3e-05 24.1 0.9 0.11 12.7 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat Thioredoxin_2 PF13098.6 ETO01616.1 - 5e-05 23.7 0.0 0.0003 21.2 0.0 2.4 1 0 0 1 1 1 1 Thioredoxin-like domain ScsC_N PF18312.1 ETO01616.1 - 5.3e-05 22.9 1.9 0.00022 21.0 0.2 2.5 2 0 0 2 2 2 1 Copper resistance protein ScsC N-terminal domain Fis1_TPR_C PF14853.6 ETO01616.1 - 7.4e-05 22.7 0.5 0.00061 19.8 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 ETO01616.1 - 0.00012 22.7 0.0 0.00028 21.4 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat RYDR_ITPR PF01365.21 ETO01616.1 - 0.0012 18.3 0.5 0.0012 18.3 0.5 3.3 4 0 0 4 4 4 1 RIH domain ANAPC3 PF12895.7 ETO01616.1 - 0.0069 16.6 1.7 0.55 10.5 0.2 2.8 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Thioredoxin PF00085.20 ETO01616.1 - 0.013 15.5 2.4 0.05 13.6 0.2 3.3 3 1 1 4 4 4 0 Thioredoxin Thioredoxin_3 PF13192.6 ETO01616.1 - 0.025 14.6 3.0 3.2 7.9 0.1 3.4 3 0 0 3 3 2 0 Thioredoxin domain DUF2661 PF10860.8 ETO01616.1 - 0.34 11.0 6.4 4.3 7.5 0.1 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF2661) TPR_17 PF13431.6 ETO01616.1 - 0.45 11.0 4.2 23 5.7 0.0 3.7 4 0 0 4 4 2 0 Tetratricopeptide repeat Goodbye PF17109.5 ETO01618.1 - 0.013 15.9 0.3 0.017 15.6 0.3 1.1 1 0 0 1 1 1 0 fungal STAND N-terminal Goodbye domain ETRAMP PF09716.10 ETO01618.1 - 0.017 15.1 1.0 0.025 14.6 1.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF1453 PF07301.11 ETO01618.1 - 0.052 13.5 0.0 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1453) ST7 PF04184.12 ETO01618.1 - 0.058 11.9 0.0 0.06 11.8 0.0 1.0 1 0 0 1 1 1 0 ST7 protein DUF819 PF05684.12 ETO01618.1 - 0.079 12.0 0.0 0.086 11.9 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF819) Nucleoside_tran PF01733.18 ETO01618.1 - 0.12 11.7 0.1 0.13 11.7 0.1 1.0 1 0 0 1 1 1 0 Nucleoside transporter OAD_gamma PF04277.13 ETO01618.1 - 0.21 12.2 0.1 0.28 11.8 0.1 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TPR_12 PF13424.6 ETO01623.1 - 9.1e-14 51.5 0.1 3.6e-08 33.6 0.0 2.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01623.1 - 4.6e-09 35.9 0.0 0.00048 19.9 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01623.1 - 6.5e-09 35.2 8.3 1.3e-05 24.8 1.5 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01623.1 - 7.3e-08 31.9 4.7 0.0015 18.4 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01623.1 - 3.3e-07 30.0 7.1 0.0033 17.5 0.7 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01623.1 - 1e-06 28.3 0.1 0.027 14.5 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO01623.1 - 0.00012 22.0 4.1 0.13 12.3 0.0 3.1 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO01623.1 - 0.0045 16.7 4.0 0.0081 15.9 2.0 1.9 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETO01623.1 - 0.031 13.9 5.6 2.2 8.0 0.1 3.2 3 1 1 4 4 4 0 TPR repeat TPR_3 PF07720.12 ETO01623.1 - 1.9 8.6 8.5 2.7 8.1 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01623.1 - 2.1 8.9 5.4 1.4 9.5 0.5 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat zf-C3HC4_2 PF13923.6 ETO01624.1 - 0.066 13.1 7.0 0.23 11.3 3.9 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) EP400_N PF15790.5 ETO01625.1 - 0.34 9.7 5.7 0.41 9.4 5.7 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal MMR_HSR1 PF01926.23 ETO01626.1 - 1.6e-05 25.0 0.4 0.00015 21.8 0.0 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO01626.1 - 3.5e-05 23.8 2.2 0.00087 19.2 0.1 3.2 3 1 2 5 5 5 1 RsgA GTPase ABC_tran PF00005.27 ETO01626.1 - 0.0019 18.7 1.7 0.0031 18.0 0.0 2.2 2 1 0 2 2 2 1 ABC transporter AAA_19 PF13245.6 ETO01626.1 - 0.01 16.2 1.9 0.056 13.8 1.9 2.4 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ETO01626.1 - 0.015 14.3 0.1 0.057 12.5 0.0 1.9 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_29 PF13555.6 ETO01626.1 - 0.017 14.9 0.1 0.036 13.8 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Dynamin_N PF00350.23 ETO01626.1 - 0.02 15.0 3.2 0.85 9.6 0.0 3.3 2 1 1 3 3 3 0 Dynamin family AAA_22 PF13401.6 ETO01626.1 - 0.027 14.7 1.3 0.32 11.2 0.0 2.9 3 1 0 3 3 3 0 AAA domain DUF815 PF05673.13 ETO01626.1 - 0.035 13.3 0.3 0.31 10.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF815) AAA_28 PF13521.6 ETO01626.1 - 0.039 14.2 0.2 0.2 11.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 ETO01626.1 - 0.06 12.8 0.1 0.31 10.5 0.0 2.1 2 0 0 2 2 2 0 PhoH-like protein AAA_7 PF12775.7 ETO01626.1 - 0.094 12.2 0.0 0.22 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_16 PF13191.6 ETO01626.1 - 0.18 12.2 0.4 2.2 8.6 0.0 2.6 2 1 0 2 2 2 0 AAA ATPase domain DUF3399 PF11879.8 ETO01626.1 - 0.21 11.9 7.0 1 9.7 0.7 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) Terminase_2 PF03592.16 ETO01626.1 - 0.7 10.3 4.8 0.47 10.9 1.3 2.4 1 1 0 2 2 2 0 Terminase small subunit Exo_endo_phos_2 PF14529.6 ETO01627.1 - 1.1e-14 54.3 2.6 1.6e-14 53.8 2.5 1.3 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Baculo_FP PF03258.14 ETO01627.1 - 0.029 14.5 0.2 0.059 13.5 0.2 1.5 1 0 0 1 1 1 0 Baculovirus FP protein DUF5085 PF16895.5 ETO01627.1 - 0.033 14.5 0.4 0.96 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5085) Peptidase_C36 PF05415.11 ETO01627.1 - 0.067 13.4 0.0 0.11 12.7 0.0 1.5 1 1 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase Disaggr_assoc PF08480.10 ETO01628.1 - 0.049 13.5 0.0 0.055 13.3 0.0 1.2 1 0 0 1 1 1 0 Disaggregatase related BOFC_N PF08977.10 ETO01629.1 - 0.029 14.4 4.0 0.32 11.0 0.7 2.3 2 0 0 2 2 2 0 Bypass of Forespore C, N terminal DUF3292 PF11696.8 ETO01629.1 - 0.074 11.4 1.7 0.086 11.2 1.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) LRAT PF04970.13 ETO01629.1 - 0.089 13.1 1.1 0.1 12.9 1.1 1.1 1 0 0 1 1 1 0 Lecithin retinol acyltransferase Prok-E2_D PF14460.6 ETO01629.1 - 1.2 8.8 6.3 3.1 7.5 3.4 2.0 1 1 1 2 2 2 0 Prokaryotic E2 family D RRM_1 PF00076.22 ETO01633.1 - 2.5e-08 33.6 0.0 0.00032 20.5 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO01633.1 - 8.3e-05 22.5 0.0 0.4 10.7 0.0 2.3 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif DUF4651 PF15513.6 ETO01633.1 - 0.092 12.6 0.0 0.96 9.3 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4651) RL PF17797.1 ETO01633.1 - 0.14 12.1 1.6 5.3 7.1 0.0 3.0 3 0 0 3 3 3 0 RL domain HisKA PF00512.25 ETO01634.1 - 0.057 13.5 1.0 0.13 12.3 0.2 1.9 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain LAGLIDADG_WhiA PF14527.6 ETO01634.1 - 0.084 13.0 5.9 1.5 9.0 0.2 3.3 2 1 1 3 3 3 0 WhiA LAGLIDADG-like domain Peptidase_C14 PF00656.22 ETO01641.1 - 6.3e-15 55.8 0.2 1.2e-14 54.8 0.2 1.4 1 0 0 1 1 1 1 Caspase domain Adeno_PV PF03910.13 ETO01641.1 - 0.2 10.3 0.4 0.33 9.6 0.4 1.3 1 0 0 1 1 1 0 Adenovirus minor core protein PV TPR_12 PF13424.6 ETO01642.1 - 4.4e-39 132.6 1.1 1.7e-13 50.7 0.3 4.2 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01642.1 - 5.8e-16 57.6 18.1 4.4e-08 32.6 1.9 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01642.1 - 1.7e-14 53.2 0.0 8.4e-07 28.7 0.2 5.1 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01642.1 - 1.1e-12 47.0 8.8 6.1e-06 26.0 0.4 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01642.1 - 1.1e-12 47.0 0.7 0.011 15.6 0.0 4.7 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01642.1 - 1.9e-11 43.2 10.8 1.3e-05 24.9 0.9 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01642.1 - 5.6e-06 25.9 4.7 0.26 11.0 0.0 4.3 4 1 1 5 5 5 3 TPR repeat RPN7 PF10602.9 ETO01642.1 - 0.00029 20.6 1.3 0.0005 19.8 0.2 2.0 2 1 0 2 2 2 1 26S proteasome subunit RPN7 DUF627 PF04781.12 ETO01642.1 - 0.00058 19.8 0.1 0.0039 17.2 0.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF627) TPR_14 PF13428.6 ETO01642.1 - 0.0046 17.7 0.0 2.3 9.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO01642.1 - 0.014 15.3 0.2 4 7.2 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO01642.1 - 0.11 13.1 0.1 33 5.4 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat Whib PF02467.16 ETO01642.1 - 0.23 12.1 1.7 0.84 10.3 1.7 2.0 1 1 0 1 1 1 0 Transcription factor WhiB TPR_17 PF13431.6 ETO01642.1 - 1.3 9.6 3.6 37 5.0 0.4 3.8 3 1 1 4 4 3 0 Tetratricopeptide repeat MMR_HSR1 PF01926.23 ETO01643.1 - 1.1e-05 25.4 0.2 3.4e-05 23.9 0.2 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase T2SSE PF00437.20 ETO01643.1 - 0.00092 18.3 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein G-alpha PF00503.20 ETO01643.1 - 0.0012 18.1 0.1 0.0017 17.6 0.1 1.4 1 0 0 1 1 1 1 G-protein alpha subunit Thymidylate_kin PF02223.17 ETO01643.1 - 0.0027 17.4 1.5 2 8.1 0.0 2.6 2 0 0 2 2 2 2 Thymidylate kinase ResIII PF04851.15 ETO01643.1 - 0.003 17.6 0.3 0.0061 16.6 0.2 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Septin PF00735.18 ETO01643.1 - 0.0091 15.3 0.7 0.018 14.3 0.0 1.8 1 1 1 2 2 2 1 Septin SRP54 PF00448.22 ETO01643.1 - 0.014 15.1 0.2 0.28 10.8 0.2 2.2 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain Gtr1_RagA PF04670.12 ETO01643.1 - 0.014 14.8 0.0 0.035 13.5 0.0 1.6 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ETO01643.1 - 0.019 14.9 0.4 0.071 13.0 0.2 2.1 1 1 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ETO01643.1 - 0.032 14.8 0.1 0.075 13.6 0.0 1.8 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ETO01643.1 - 0.032 14.5 0.3 0.063 13.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO01643.1 - 0.034 13.5 0.0 0.064 12.6 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family Arf PF00025.21 ETO01643.1 - 0.058 12.8 0.3 0.2 11.1 0.3 1.9 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA_29 PF13555.6 ETO01643.1 - 0.069 12.9 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ETO01643.1 - 0.091 12.8 0.0 0.22 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PduV-EutP PF10662.9 ETO01643.1 - 0.098 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 ETO01643.1 - 0.13 12.7 0.2 2.1 8.8 0.2 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO01643.1 - 0.15 12.4 0.0 0.22 11.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_23 PF13476.6 ETO01643.1 - 7.6 7.0 12.7 0.092 13.2 0.4 2.4 1 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ETO01645.1 - 2.5e-12 47.0 0.1 6.1e-11 42.5 0.0 2.4 1 1 1 2 2 2 1 NACHT domain NB-ARC PF00931.22 ETO01645.1 - 0.00056 19.2 0.0 0.001 18.3 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ETO01645.1 - 0.00062 20.2 0.0 0.0029 18.0 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain ApoA-II PF04711.13 ETO01645.1 - 0.01 16.0 1.0 0.78 9.9 0.1 2.4 2 0 0 2 2 2 0 Apolipoprotein A-II (ApoA-II) AAA_22 PF13401.6 ETO01645.1 - 0.011 16.0 0.2 0.038 14.3 0.2 2.1 1 1 0 1 1 1 0 AAA domain Torsin PF06309.11 ETO01645.1 - 0.085 13.0 0.0 0.17 12.0 0.0 1.5 1 0 0 1 1 1 0 Torsin DUF87 PF01935.17 ETO01645.1 - 0.096 12.8 2.2 0.31 11.1 0.9 2.6 1 1 0 1 1 1 0 Helicase HerA, central domain WD40 PF00400.32 ETO01650.1 - 5.7e-06 27.0 0.3 5.7e-06 27.0 0.3 3.2 3 2 0 3 3 3 1 WD domain, G-beta repeat LPD30 PF18850.1 ETO01651.1 - 0.081 12.7 0.0 0.1 12.4 0.0 1.1 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 Pkinase PF00069.25 ETO01653.1 - 4.6e-47 160.6 0.1 5.5e-47 160.3 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO01653.1 - 4.9e-24 85.0 0.1 5.3e-24 84.9 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO01653.1 - 1.5e-05 24.5 0.1 2.1e-05 24.0 0.1 1.1 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO01653.1 - 0.00029 20.3 0.0 0.00035 20.0 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO01653.1 - 0.0063 15.3 0.0 0.0074 15.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO01653.1 - 0.0086 15.1 0.1 0.01 14.8 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pox_ser-thr_kin PF05445.11 ETO01653.1 - 0.014 14.4 1.1 0.019 14.0 1.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 ETO01653.1 - 0.035 14.0 0.1 0.041 13.8 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ETO01653.1 - 0.042 13.5 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 TPR_12 PF13424.6 ETO01654.1 - 6.1e-73 241.1 9.8 7.2e-21 74.3 0.2 4.8 1 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01654.1 - 1.2e-53 177.6 0.7 3.4e-10 39.5 0.0 6.7 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01654.1 - 2.2e-37 125.3 35.0 3.4e-08 33.0 0.2 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01654.1 - 1.9e-36 121.4 10.1 4.7e-06 26.2 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01654.1 - 3.4e-30 101.7 24.5 2.1e-06 27.4 0.6 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01654.1 - 4e-28 95.2 36.4 8.9e-07 28.7 1.1 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01654.1 - 7.5e-15 54.2 12.7 0.0024 18.1 0.2 6.2 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01654.1 - 2e-13 50.8 0.0 0.2 12.4 0.0 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO01654.1 - 3.9e-13 49.5 0.0 3.3e-08 33.3 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 ETO01654.1 - 3.9e-10 39.7 0.0 1.1 10.3 0.0 5.7 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01654.1 - 4.1e-09 36.0 34.9 0.043 13.5 1.7 8.9 6 4 4 10 10 10 4 TPR repeat TPR_3 PF07720.12 ETO01654.1 - 1.4e-08 34.5 17.1 0.1 12.6 0.1 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETO01654.1 - 8.4e-08 32.2 15.9 0.047 13.5 0.4 5.4 5 1 1 6 6 5 3 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO01654.1 - 1.2e-07 31.9 7.4 0.95 10.2 0.1 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat PPR PF01535.20 ETO01654.1 - 1.5e-07 31.2 11.2 0.54 10.6 0.1 5.7 6 0 0 6 6 5 3 PPR repeat TPR_19 PF14559.6 ETO01654.1 - 5.4e-05 23.6 1.3 0.51 10.9 0.0 4.2 3 1 2 5 5 5 1 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO01654.1 - 0.00027 20.4 1.5 7.7 6.2 0.1 5.3 5 0 0 5 5 5 0 Helix-turn-helix bacterial domain DUF5112 PF17139.4 ETO01654.1 - 0.0006 19.4 0.8 4 6.8 0.0 3.3 1 1 2 3 3 3 1 Domain of unknown function (DUF5112) ANAPC3 PF12895.7 ETO01654.1 - 0.0011 19.2 16.8 0.28 11.5 0.9 4.3 2 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO01654.1 - 0.0016 19.0 2.6 14 6.3 0.0 4.2 1 1 1 3 3 3 0 Domain of unknown function (DUF4810) DUF3450 PF11932.8 ETO01654.1 - 0.016 14.5 0.7 4.8 6.4 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF3450) HisG PF01634.18 ETO01654.1 - 0.02 14.9 0.1 9.1 6.2 0.0 3.2 1 1 2 3 3 3 0 ATP phosphoribosyltransferase Pep3_Vps18 PF05131.14 ETO01654.1 - 0.023 14.5 4.0 5.5 6.8 0.0 4.3 5 0 0 5 5 5 0 Pep3/Vps18/deep orange family FATC PF02260.20 ETO01654.1 - 0.2 11.5 1.0 70 3.4 0.2 3.2 3 0 0 3 3 3 0 FATC domain MIT PF04212.18 ETO01654.1 - 1.3 9.2 21.5 35 4.6 0.1 6.3 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 ETO01654.1 - 7.3 7.4 19.1 59 4.6 0.1 7.4 7 2 1 8 8 8 0 Sel1 repeat Clathrin PF00637.20 ETO01654.1 - 7.8 6.4 11.7 7.3 6.5 0.3 4.6 2 1 2 4 4 4 0 Region in Clathrin and VPS CALCOCO1 PF07888.11 ETO01655.1 - 0.0032 16.4 10.5 0.0032 16.4 10.5 2.0 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like BAAT_C PF08840.11 ETO01655.1 - 0.025 14.5 1.3 0.04 13.8 1.3 1.4 1 0 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal CSN5_C PF18323.1 ETO01655.1 - 1.6 9.7 8.7 3.1 8.8 8.2 1.7 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain Latarcin PF10279.9 ETO01655.1 - 2 8.9 11.7 0.26 11.7 3.9 2.5 2 1 1 3 3 3 0 Latarcin precursor GDI PF00996.18 ETO01656.1 - 4.8e-31 107.7 0.0 8.9e-31 106.9 0.0 1.4 1 1 0 1 1 1 1 GDP dissociation inhibitor E3_UbLigase_R4 PF13764.6 ETO01656.1 - 0.0092 14.2 0.4 0.011 13.9 0.4 1.1 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 DUF262 PF03235.14 ETO01656.1 - 0.15 12.3 7.4 0.048 13.8 4.7 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF262 FAM163 PF15069.6 ETO01656.1 - 0.3 11.5 2.1 0.78 10.2 2.1 1.7 1 0 0 1 1 1 0 FAM163 family RXT2_N PF08595.11 ETO01656.1 - 5 7.1 11.5 7.4 6.6 8.0 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal EpoR_lig-bind PF09067.10 ETO01657.1 - 0.032 14.4 0.2 0.058 13.6 0.2 1.4 1 0 0 1 1 1 0 Erythropoietin receptor, ligand binding Acetyltransf_13 PF13880.6 ETO01657.1 - 0.049 13.6 0.0 3.1 7.9 0.0 2.4 2 0 0 2 2 2 0 ESCO1/2 acetyl-transferase FRG PF08867.11 ETO01657.1 - 0.11 13.5 0.4 0.21 12.5 0.4 1.6 1 1 0 1 1 1 0 FRG domain WD40 PF00400.32 ETO01658.1 - 6.3e-10 39.5 1.1 1.3e-06 29.0 0.2 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01658.1 - 1.1e-05 25.7 0.0 1.3e-05 25.4 0.0 1.2 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01658.1 - 0.015 14.0 0.0 0.015 14.0 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PBECR1 PF18809.1 ETO01659.1 - 0.15 12.7 1.3 0.25 12.0 0.9 1.6 1 1 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 Zip PF02535.22 ETO01660.1 - 0.00011 21.6 7.3 0.00014 21.2 7.3 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter SDA1 PF05285.12 ETO01660.1 - 0.059 12.8 6.6 0.063 12.7 6.6 1.1 1 0 0 1 1 1 0 SDA1 Drc1-Sld2 PF11719.8 ETO01660.1 - 0.096 12.2 2.4 0.12 11.9 2.4 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein V_ATPase_I PF01496.19 ETO01660.1 - 0.38 8.6 2.5 0.54 8.1 2.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pox_P35 PF03213.14 ETO01660.1 - 1 8.5 4.0 1.6 7.9 4.0 1.3 1 0 0 1 1 1 0 Poxvirus P35 protein DUF2457 PF10446.9 ETO01660.1 - 1.6 7.8 20.2 2.3 7.3 20.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFIIF_alpha PF05793.12 ETO01660.1 - 2.1 6.9 13.2 2.9 6.4 13.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ETO01660.1 - 3 5.8 8.2 3.2 5.7 8.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO01660.1 - 4.8 5.4 11.3 6.4 4.9 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DEAD PF00270.29 ETO01662.1 - 2.6e-10 40.4 0.0 6.1e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase DEP PF00610.21 ETO01664.1 - 4.6e-23 81.0 0.1 7.3e-23 80.4 0.1 1.3 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) WD40 PF00400.32 ETO01665.1 - 1e-14 54.7 5.1 8.8e-07 29.5 0.9 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01665.1 - 0.072 13.4 0.1 2.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Vfa1 PF08432.10 ETO01666.1 - 0.097 13.0 27.6 0.13 12.6 27.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PNISR PF15996.5 ETO01666.1 - 0.62 10.3 30.2 1 9.6 30.2 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4662 PF15578.6 ETO01666.1 - 3.9 7.2 13.1 4.4 7.0 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) NPR3 PF03666.13 ETO01666.1 - 4 6.1 24.4 4.2 6.1 24.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.12 ETO01666.1 - 6.8 4.8 31.6 7.2 4.7 31.6 1.0 1 0 0 1 1 1 0 Nop14-like family SecA_DEAD PF07517.14 ETO01668.1 - 2.2e-08 33.8 0.0 2.2e-08 33.8 0.0 3.5 2 1 1 3 3 3 1 SecA DEAD-like domain DUF5601 PF18151.1 ETO01668.1 - 0.0084 16.4 1.7 10 6.5 0.5 4.0 2 0 0 2 2 2 2 Domain of unknown function (DUF5601) Sec23_helical PF04815.15 ETO01668.1 - 0.02 14.7 2.7 2.8 7.8 0.1 4.3 3 1 1 4 4 4 0 Sec23/Sec24 helical domain HOIP-UBA PF16678.5 ETO01668.1 - 0.11 12.5 9.3 0.039 14.0 2.7 3.1 2 1 1 3 3 3 0 HOIP UBA domain pair MitMem_reg PF13012.6 ETO01668.1 - 0.16 12.4 7.9 0.79 10.2 1.3 4.7 3 2 0 3 3 3 0 Maintenance of mitochondrial structure and function T3SS_basalb_I PF17001.5 ETO01668.1 - 0.32 11.6 4.0 2 9.1 0.1 3.7 2 1 0 2 2 2 0 Type III secretion basal body protein I, YscI, HrpB, PscI CarD_CdnL_TRCF PF02559.16 ETO01668.1 - 0.7 10.6 11.1 1.2 9.8 1.0 3.5 3 0 0 3 3 3 0 CarD-like/TRCF domain DUF948 PF06103.11 ETO01668.1 - 0.77 10.1 12.5 3.5 8.0 0.5 5.0 2 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CLZ PF16526.5 ETO01668.1 - 1.8 9.0 8.7 1 9.8 1.0 4.2 3 0 0 3 3 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YtxH PF12732.7 ETO01668.1 - 3.5 8.2 10.8 2.3 8.8 0.3 4.7 4 1 0 4 4 3 0 YtxH-like protein AP4E_app_platf PF14807.6 ETO01668.1 - 4.2 7.8 8.2 4.6 7.7 0.2 4.1 4 0 0 4 4 4 0 Adaptin AP4 complex epsilon appendage platform ECSCR PF15820.5 ETO01669.1 - 1.4 8.8 5.5 4.1 7.3 5.5 1.8 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator DUF2358 PF10184.9 ETO01670.1 - 0.0055 17.0 0.1 0.024 14.9 0.0 1.9 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2358) YlbE PF14003.6 ETO01670.1 - 0.094 13.2 0.2 0.24 11.9 0.1 1.7 2 0 0 2 2 2 0 YlbE-like protein Fip1 PF05182.13 ETO01671.1 - 3.1e-20 71.4 3.9 5.2e-20 70.7 3.9 1.4 1 0 0 1 1 1 1 Fip1 motif STI1 PF17830.1 ETO01673.1 - 0.17 11.8 6.2 0.25 11.3 0.0 3.0 3 0 0 3 3 3 0 STI1 domain tRNA-synt_2 PF00152.20 ETO01674.1 - 1e-25 90.5 0.8 1.1e-25 90.4 0.8 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) PPR_3 PF13812.6 ETO01678.1 - 1.1e-11 44.7 0.4 0.00022 21.3 0.0 3.5 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO01678.1 - 1.1e-10 41.6 1.5 1.4e-06 28.4 0.1 3.5 2 1 1 3 3 3 3 PPR repeat family PPR_1 PF12854.7 ETO01678.1 - 4.9e-09 35.7 0.4 0.0016 18.1 0.0 3.4 3 0 0 3 3 3 3 PPR repeat PPR PF01535.20 ETO01678.1 - 3.6e-08 33.1 0.5 0.00074 19.6 0.1 2.9 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 ETO01678.1 - 0.0023 17.3 0.0 0.0033 16.8 0.0 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF1350 PF07082.11 ETO01679.1 - 0.14 11.4 0.0 0.16 11.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1350) Guanylate_cyc PF00211.20 ETO01680.1 - 7.5e-21 74.6 1.0 2.5e-20 72.9 1.0 1.7 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain MRF_C2 PF13888.6 ETO01681.1 - 0.069 13.0 0.2 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Myelin gene regulatory factor C-terminal domain 2 RsgA_GTPase PF03193.16 ETO01683.1 - 2.1e-05 24.5 0.7 0.0026 17.7 0.0 3.5 3 0 0 3 3 3 1 RsgA GTPase AAA_19 PF13245.6 ETO01683.1 - 0.00014 22.2 3.4 0.0017 18.7 1.1 3.0 2 1 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ETO01683.1 - 0.00047 20.2 0.1 0.0065 16.5 0.1 3.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO01683.1 - 0.0054 17.3 0.0 0.0054 17.3 0.0 3.1 3 0 0 3 3 3 1 ABC transporter AAA_29 PF13555.6 ETO01683.1 - 0.011 15.5 0.0 0.027 14.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO01683.1 - 0.016 15.5 3.5 0.12 12.6 0.0 3.5 3 1 0 4 4 4 0 AAA domain T2SSE PF00437.20 ETO01683.1 - 0.028 13.5 0.0 0.07 12.2 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_28 PF13521.6 ETO01683.1 - 0.042 14.1 0.1 0.14 12.4 0.1 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO01683.1 - 0.044 14.2 0.2 2.6 8.4 0.0 2.8 2 0 0 2 2 2 0 AAA ATPase domain PI_PP_I PF18363.1 ETO01683.1 - 0.061 13.5 2.7 14 6.0 0.1 3.8 4 0 0 4 4 3 0 Phosphoinositide phosphatase insertion domain AAA_7 PF12775.7 ETO01683.1 - 0.068 12.7 0.5 0.17 11.4 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 ETO01683.1 - 0.07 12.6 0.0 0.22 11.0 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein rve_3 PF13683.6 ETO01683.1 - 0.092 12.5 0.0 0.52 10.1 0.0 2.3 1 0 0 1 1 1 0 Integrase core domain DUF5388 PF17363.2 ETO01683.1 - 1.6 9.0 10.5 6.3 7.1 0.1 4.8 5 0 0 5 5 5 0 Family of unknown function (DUF5388) Alpha_adaptinC2 PF02883.20 ETO01684.1 - 0.034 14.4 0.5 0.046 14.0 0.5 1.2 1 0 0 1 1 1 0 Adaptin C-terminal domain CDC45 PF02724.14 ETO01685.1 - 0.00046 18.6 12.2 0.00053 18.4 12.2 1.0 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 ETO01685.1 - 0.0079 16.3 17.1 0.013 15.7 17.1 1.3 1 0 0 1 1 1 1 YL1 nuclear protein AAA_11 PF13086.6 ETO01685.1 - 0.016 15.0 3.9 0.018 14.9 3.9 1.1 1 0 0 1 1 1 0 AAA domain SLC12 PF03522.15 ETO01685.1 - 0.017 14.1 5.2 0.02 13.9 5.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 SDA1 PF05285.12 ETO01685.1 - 0.018 14.5 17.5 0.024 14.1 17.5 1.2 1 0 0 1 1 1 0 SDA1 Cwf_Cwc_15 PF04889.12 ETO01685.1 - 0.029 14.1 20.3 0.038 13.7 20.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 ETO01685.1 - 0.03 12.6 16.8 0.045 12.0 16.8 1.2 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 ETO01685.1 - 0.03 14.7 3.8 0.04 14.4 3.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 SAPS PF04499.15 ETO01685.1 - 0.056 12.2 4.6 0.056 12.2 4.6 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sporozoite_P67 PF05642.11 ETO01685.1 - 0.068 11.3 6.3 0.077 11.1 6.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4746 PF15928.5 ETO01685.1 - 0.11 12.0 6.1 0.12 11.7 6.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF913 PF06025.12 ETO01685.1 - 0.12 11.3 2.6 0.13 11.2 2.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO01685.1 - 0.15 11.3 3.2 0.16 11.1 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Pes-10 PF07149.11 ETO01685.1 - 0.15 11.1 13.4 0.2 10.7 13.4 1.1 1 0 0 1 1 1 0 Pes-10 Sin_N PF04801.13 ETO01685.1 - 0.2 10.8 9.8 0.26 10.5 9.8 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region RR_TM4-6 PF06459.12 ETO01685.1 - 0.21 11.4 12.5 0.27 11.0 12.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 ETO01685.1 - 0.23 10.2 6.1 0.27 9.9 6.1 1.1 1 0 0 1 1 1 0 Raftlin NPR3 PF03666.13 ETO01685.1 - 0.47 9.2 9.1 0.56 8.9 9.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop53 PF07767.11 ETO01685.1 - 0.68 9.3 20.6 0.96 8.8 20.6 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) AIF_C PF14721.6 ETO01685.1 - 0.76 10.1 9.2 0.088 13.2 0.7 2.1 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CRA PF06589.11 ETO01685.1 - 0.95 9.6 10.0 1.9 8.6 10.0 1.6 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) PTPRCAP PF15713.5 ETO01685.1 - 1.1 9.5 12.4 1.6 9.0 12.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CCDC106 PF15794.5 ETO01685.1 - 1.2 8.8 13.8 1.8 8.2 13.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF4614 PF15391.6 ETO01685.1 - 1.6 8.7 7.1 2.2 8.3 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Med19 PF10278.9 ETO01685.1 - 1.8 8.4 18.4 0.099 12.6 13.2 1.4 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Neur_chan_memb PF02932.16 ETO01685.1 - 1.9 8.5 5.1 2.1 8.3 5.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MDM10 PF12519.8 ETO01685.1 - 2.6 6.8 8.1 3.3 6.5 8.1 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 TRAP_alpha PF03896.16 ETO01685.1 - 2.9 7.0 7.0 3.8 6.6 7.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 ETO01685.1 - 3 6.5 11.7 3.8 6.2 11.7 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETO01685.1 - 3 5.8 7.0 3.6 5.6 7.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Connexin PF00029.19 ETO01685.1 - 3.2 7.5 13.2 13 5.4 13.3 1.8 1 1 0 1 1 1 0 Connexin RNA_polI_A34 PF08208.11 ETO01685.1 - 3.4 7.7 19.9 5.1 7.1 19.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 ALMT PF11744.8 ETO01685.1 - 4.5 6.0 7.9 5.9 5.6 7.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_C14 PF00656.22 ETO01686.1 - 0.0012 18.9 0.1 0.002 18.1 0.1 1.4 1 1 0 1 1 1 1 Caspase domain DUF4158 PF13700.6 ETO01687.1 - 0.086 12.7 0.0 0.13 12.1 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4158) Acetyltransf_7 PF13508.7 ETO01687.1 - 0.092 13.2 0.1 2.3 8.7 0.0 2.3 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF166 PF02593.14 ETO01687.1 - 0.13 11.8 1.5 0.16 11.5 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function zf-C2H2 PF00096.26 ETO01687.1 - 0.6 10.7 2.2 14 6.4 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Kelch_1 PF01344.25 ETO01689.1 - 7.1e-11 41.5 3.6 8.4e-07 28.5 0.5 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO01689.1 - 2.1e-08 34.0 0.1 0.00048 20.1 0.1 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO01689.1 - 3.9e-08 33.0 1.0 6.8e-05 22.7 0.3 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO01689.1 - 2.6e-07 30.5 0.1 0.0023 17.9 0.2 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO01689.1 - 7.3e-07 29.2 0.5 0.0071 16.6 0.3 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO01689.1 - 2e-06 28.0 0.7 0.00029 21.1 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain WD40 PF00400.32 ETO01691.1 - 4e-09 36.9 1.4 0.00014 22.6 0.1 2.9 2 1 0 2 2 2 2 WD domain, G-beta repeat DUF261 PF03196.13 ETO01692.1 - 0.003 17.6 1.9 0.0041 17.2 1.9 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF261 COG4 PF08318.12 ETO01692.1 - 0.032 13.3 0.8 0.038 13.1 0.8 1.0 1 0 0 1 1 1 0 COG4 transport protein Cytochrom_B562 PF07361.11 ETO01693.1 - 0.035 14.8 0.4 0.088 13.5 0.4 1.7 1 0 0 1 1 1 0 Cytochrome b562 Nsp1_C PF05064.13 ETO01693.1 - 0.23 11.3 4.5 0.078 12.8 1.2 1.9 2 0 0 2 2 2 0 Nsp1-like C-terminal region DUF4456 PF14644.6 ETO01693.1 - 0.31 10.7 4.6 7.9 6.1 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4456) TFIIIC_sub6 PF10419.9 ETO01694.1 - 0.14 12.0 0.1 0.29 11.0 0.1 1.4 1 0 0 1 1 1 0 TFIIIC subunit triple barrel domain Phage_GP20 PF06810.11 ETO01696.1 - 0.13 12.0 40.3 0.89 9.4 18.1 3.2 1 1 2 3 3 3 0 Phage minor structural protein GP20 DUF16 PF01519.16 ETO01696.1 - 0.26 11.8 40.5 0.33 11.4 14.9 3.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 CHASE3 PF05227.13 ETO01696.1 - 0.34 10.8 18.5 1.1 9.2 1.8 3.0 1 1 1 2 2 2 0 CHASE3 domain HrpB7 PF09486.10 ETO01696.1 - 0.44 10.9 14.3 0.74 10.2 14.3 1.5 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF3584 PF12128.8 ETO01696.1 - 0.61 7.5 32.6 0.75 7.2 32.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4407 PF14362.6 ETO01696.1 - 0.84 8.9 20.9 1.1 8.5 20.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EzrA PF06160.12 ETO01696.1 - 1.1 7.4 37.7 3.7 5.6 20.3 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA ADIP PF11559.8 ETO01696.1 - 1.2 9.2 41.5 0.38 10.8 27.6 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ETO01696.1 - 1.3 9.2 35.9 39 4.4 34.4 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) V_ATPase_I PF01496.19 ETO01696.1 - 1.4 6.8 26.2 1.7 6.4 26.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DNA_methylase PF00145.17 ETO01696.1 - 2.9 7.1 17.4 3.5 6.9 17.4 1.2 1 0 0 1 1 1 0 C-5 cytosine-specific DNA methylase DUF2381 PF09544.10 ETO01696.1 - 3.1 7.3 6.0 0.43 10.1 1.1 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF2381) APG6_N PF17675.1 ETO01696.1 - 3.5 8.2 37.8 11 6.6 23.1 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Asp-B-Hydro_N PF05279.11 ETO01696.1 - 6.7 6.7 23.5 7.5 6.5 23.5 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region YabA PF06156.13 ETO01696.1 - 7.8 7.2 33.9 5.8 7.6 13.9 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Mod_r PF07200.13 ETO01696.1 - 8.5 6.5 37.7 1.7 8.8 19.2 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CENP-F_leu_zip PF10473.9 ETO01699.1 - 0.0067 16.5 7.0 0.016 15.2 7.0 1.7 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 zf-C2H2_9 PF16293.5 ETO01699.1 - 0.0072 16.1 2.4 0.027 14.3 0.4 2.6 2 0 0 2 2 2 1 C2H2 type zinc-finger (1 copy) Kazal_3 PF18434.1 ETO01699.1 - 0.095 12.5 0.8 10 5.9 0.2 2.4 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain FlaC_arch PF05377.11 ETO01699.1 - 0.31 11.5 3.9 0.95 9.9 3.9 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Bap31_Bap29_C PF18035.1 ETO01699.1 - 0.41 10.7 10.2 20 5.3 6.3 3.6 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain CCDC-167 PF15188.6 ETO01699.1 - 0.59 10.5 6.1 2.5 8.5 6.1 2.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF1664 PF07889.12 ETO01699.1 - 0.69 10.0 4.6 0.72 9.9 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DivIC PF04977.15 ETO01699.1 - 1 9.2 4.6 2.8 7.8 4.6 1.8 1 0 0 1 1 1 0 Septum formation initiator XhlA PF10779.9 ETO01699.1 - 1.8 8.8 10.9 11 6.4 6.1 2.8 2 0 0 2 2 2 0 Haemolysin XhlA SlyX PF04102.12 ETO01699.1 - 2.8 8.6 6.5 7.6 7.2 5.6 2.3 2 0 0 2 2 2 0 SlyX PUB PF09409.10 ETO01700.1 - 0.013 15.4 0.4 0.055 13.4 0.4 2.0 1 1 0 1 1 1 0 PUB domain DAAD PF18752.1 ETO01701.1 - 0.15 11.9 0.9 0.24 11.2 0.9 1.3 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase RGS PF00615.19 ETO01702.1 - 4.4e-05 23.7 3.0 0.00015 22.0 3.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 ETO01703.1 - 1.2e-41 139.9 24.2 7.8e-07 29.7 1.0 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01703.1 - 2.7e-10 40.4 3.4 0.018 15.3 0.0 6.4 6 1 2 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01703.1 - 1.2e-07 30.8 4.5 0.026 13.2 0.0 4.7 2 2 2 4 4 4 2 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO01703.1 - 4.1e-06 27.4 6.3 4.1e-06 27.4 6.3 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger CDO_I PF05995.12 ETO01703.1 - 0.055 12.8 0.0 0.16 11.3 0.0 1.7 1 0 0 1 1 1 0 Cysteine dioxygenase type I DUF4407 PF14362.6 ETO01703.1 - 0.3 10.4 7.9 0.45 9.8 7.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4570 PF15134.6 ETO01703.1 - 5.5 7.0 22.1 1.9 8.6 6.6 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4570) YabA PF06156.13 ETO01704.1 - 0.003 18.1 3.2 0.36 11.5 0.0 2.2 1 1 1 2 2 2 1 Initiation control protein YabA DUF4618 PF15397.6 ETO01704.1 - 0.0079 15.6 5.2 0.0079 15.6 5.2 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4618) SSP160 PF06933.11 ETO01704.1 - 0.01 14.1 6.2 0.014 13.6 6.2 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Fmp27_WPPW PF10359.9 ETO01704.1 - 0.011 14.6 5.1 0.0079 15.1 2.2 1.9 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain FlxA PF14282.6 ETO01704.1 - 0.012 15.6 5.2 0.012 15.6 5.2 2.5 3 0 0 3 3 2 0 FlxA-like protein Troponin PF00992.20 ETO01704.1 - 0.022 15.0 5.9 0.022 15.0 5.9 2.1 2 0 0 2 2 2 0 Troponin KASH_CCD PF14662.6 ETO01704.1 - 0.023 14.5 11.0 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 ETO01704.1 - 0.058 13.6 8.5 1.3 9.3 2.4 2.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper TSC22 PF01166.18 ETO01704.1 - 0.071 13.4 4.9 1.7 9.0 0.2 2.7 3 0 0 3 3 2 0 TSC-22/dip/bun family TMCO5 PF14992.6 ETO01704.1 - 0.11 12.1 8.9 0.32 10.5 5.7 2.0 2 0 0 2 2 2 0 TMCO5 family DUF3439 PF11921.8 ETO01704.1 - 0.12 12.4 7.0 0.22 11.5 7.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DivIC PF04977.15 ETO01704.1 - 0.26 11.1 16.8 0.43 10.4 1.2 3.0 3 1 0 4 4 4 0 Septum formation initiator OmpH PF03938.14 ETO01704.1 - 0.37 11.1 10.8 0.69 10.2 5.5 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Fungal_TACC PF12709.7 ETO01704.1 - 0.53 10.8 10.1 1 9.9 3.3 2.7 2 1 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins bZIP_2 PF07716.15 ETO01704.1 - 0.57 10.3 10.4 2.4 8.3 1.2 2.8 2 1 0 2 2 2 0 Basic region leucine zipper ApoLp-III PF07464.11 ETO01704.1 - 0.68 10.0 9.4 0.46 10.6 2.3 2.3 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Seryl_tRNA_N PF02403.22 ETO01704.1 - 0.81 9.9 11.4 0.28 11.4 5.9 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain bZIP_1 PF00170.21 ETO01704.1 - 0.87 9.7 13.6 1.6 8.9 0.4 2.9 2 1 0 2 2 2 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 ETO01704.1 - 1.2 9.3 15.6 2 8.5 7.1 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Cnn_1N PF07989.11 ETO01704.1 - 1.6 8.9 13.1 0.62 10.3 0.5 2.9 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 DivIVA PF05103.13 ETO01704.1 - 1.9 8.5 8.2 4.2 7.5 2.2 2.5 2 1 0 2 2 2 0 DivIVA protein Jnk-SapK_ap_N PF09744.9 ETO01704.1 - 2.3 8.4 14.9 2.4 8.4 7.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Tup_N PF08581.10 ETO01704.1 - 4.4 7.7 7.8 15 6.0 0.2 2.7 2 1 0 2 2 2 0 Tup N-terminal CLZ PF16526.5 ETO01704.1 - 4.7 7.6 8.6 3 8.3 3.2 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UPF0449 PF15136.6 ETO01704.1 - 4.8 7.7 7.7 13 6.3 1.7 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 GTP-bdg_M PF16360.5 ETO01704.1 - 7.6 7.2 8.0 18 6.0 0.4 2.6 1 1 0 2 2 2 0 GTP-binding GTPase Middle Region WD40 PF00400.32 ETO01707.1 - 1.4e-11 44.7 9.1 8e-05 23.3 0.0 5.8 5 1 1 6 6 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01707.1 - 1.5e-09 38.1 0.2 0.0015 18.8 0.1 4.3 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO01707.1 - 5.2e-07 29.4 13.7 2.5 8.1 0.7 6.4 6 0 0 6 6 6 4 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO01707.1 - 6e-07 29.5 1.6 0.0006 19.7 0.1 2.6 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A DPPIV_N PF00930.21 ETO01707.1 - 0.00047 19.0 3.1 0.32 9.7 0.1 4.1 2 2 2 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Kelch_1 PF01344.25 ETO01707.1 - 0.00065 19.2 0.1 0.0049 16.4 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Coatomer_WDAD PF04053.14 ETO01707.1 - 0.002 17.2 0.3 0.0057 15.7 0.2 1.9 1 1 0 1 1 1 1 Coatomer WD associated region Kelch_2 PF07646.15 ETO01707.1 - 0.018 15.0 0.2 1.1 9.4 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Lactonase PF10282.9 ETO01707.1 - 0.02 14.2 0.1 12 5.0 0.0 3.4 2 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller Kelch_6 PF13964.6 ETO01707.1 - 0.025 14.9 0.2 5.9 7.3 0.0 3.6 3 0 0 3 3 3 0 Kelch motif Cytochrom_D1 PF02239.16 ETO01707.1 - 0.037 12.5 0.0 2 6.9 0.0 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain OCRE PF17780.1 ETO01707.1 - 0.084 12.9 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 OCRE domain RhoGAP-FF1 PF16512.5 ETO01708.1 - 0.064 13.9 0.1 0.13 12.9 0.1 1.4 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain Kelch_1 PF01344.25 ETO01708.1 - 0.065 12.8 0.1 0.89 9.2 0.1 2.7 2 0 0 2 2 2 0 Kelch motif NACHT PF05729.12 ETO01709.1 - 2.1e-09 37.5 0.0 6.3e-09 36.0 0.0 1.9 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO01709.1 - 0.019 15.2 0.1 0.15 12.3 0.0 2.6 2 1 1 3 3 3 0 AAA domain RNA_helicase PF00910.22 ETO01709.1 - 0.021 15.2 0.3 0.45 10.9 0.0 3.3 3 0 0 3 3 3 0 RNA helicase AAA_18 PF13238.6 ETO01709.1 - 0.027 15.0 0.4 0.21 12.1 0.0 2.9 3 0 0 3 3 3 0 AAA domain ABC_tran PF00005.27 ETO01709.1 - 0.06 13.9 0.5 1 9.9 0.0 2.8 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ETO01709.1 - 0.081 13.3 0.1 0.76 10.1 0.0 2.4 1 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 ETO01709.1 - 0.082 13.3 0.0 0.29 11.6 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ETO01709.1 - 0.087 12.8 0.0 0.63 10.1 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Ribosomal_S20p PF01649.18 ETO01709.1 - 0.32 11.7 0.1 0.32 11.7 0.1 3.1 3 0 0 3 3 2 0 Ribosomal protein S20 RsgA_GTPase PF03193.16 ETO01709.1 - 0.72 9.7 3.4 0.66 9.9 0.1 2.7 2 1 0 2 2 2 0 RsgA GTPase YbfN PF13982.6 ETO01709.1 - 2 8.7 5.9 3.9 7.8 0.5 3.1 3 0 0 3 3 3 0 YbfN-like lipoprotein WD40 PF00400.32 ETO01710.1 - 1e-102 333.1 42.1 3.8e-10 40.2 0.2 14.4 13 1 1 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01710.1 - 8e-23 80.6 11.9 0.022 15.0 0.0 11.3 2 1 9 11 11 11 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO01710.1 - 1.1e-15 57.5 3.8 0.018 14.0 0.0 7.8 3 1 3 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO01710.1 - 1.9e-06 27.7 8.7 1.6 8.8 0.0 8.1 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO01710.1 - 3.9e-06 26.4 2.8 6.3e-06 25.7 0.9 2.4 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO01710.1 - 7.9e-05 22.7 0.4 0.0012 19.0 0.2 2.5 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) SGL PF08450.12 ETO01710.1 - 9.5e-05 22.1 0.2 0.38 10.3 0.0 4.6 3 2 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO01710.1 - 0.00073 18.2 2.1 0.15 10.5 0.0 4.3 3 2 1 5 5 5 1 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO01710.1 - 0.027 14.6 1.7 0.17 12.0 1.7 2.3 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF1938 PF09153.10 ETO01710.1 - 0.063 13.4 0.0 75 3.5 0.0 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF1938) Pneumo_M2 PF07380.11 ETO01710.1 - 0.12 12.6 0.9 3.9 7.8 0.3 3.1 2 0 0 2 2 2 0 Pneumovirus M2 protein Corona_NS8 PF12093.8 ETO01710.1 - 0.15 12.6 0.9 25 5.5 0.0 3.8 4 0 0 4 4 4 0 Coronavirus NS8 protein NYD-SP28_assoc PF14775.6 ETO01710.1 - 0.37 10.9 10.2 15 5.8 0.0 7.4 9 0 0 9 9 9 0 Sperm tail C-terminal domain CAP_GLY PF01302.25 ETO01711.1 - 0.00024 21.1 0.1 0.00067 19.6 0.0 1.8 1 1 0 1 1 1 1 CAP-Gly domain DUF4975 PF16346.5 ETO01711.1 - 0.023 14.8 0.2 0.046 13.8 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) MMR_HSR1 PF01926.23 ETO01713.1 - 7.4e-06 26.0 0.3 2.9e-05 24.1 0.3 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Septin PF00735.18 ETO01713.1 - 9.3e-06 25.1 0.3 2.1e-05 24.0 0.2 1.7 1 1 1 2 2 2 1 Septin Gtr1_RagA PF04670.12 ETO01713.1 - 4.7e-05 22.9 0.3 0.00024 20.5 0.0 2.1 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region AIG1 PF04548.16 ETO01713.1 - 0.00016 21.1 0.4 0.0013 18.1 0.0 2.1 1 1 1 2 2 2 1 AIG1 family GTP_EFTU PF00009.27 ETO01713.1 - 0.00025 20.7 0.2 0.0012 18.4 0.0 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO01713.1 - 0.00036 20.5 0.8 0.0019 18.2 0.8 2.1 1 1 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ETO01713.1 - 0.0022 17.7 0.1 0.0046 16.7 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO01713.1 - 0.0093 16.5 0.9 0.014 15.9 0.7 1.5 1 1 0 1 1 1 1 AAA domain G-alpha PF00503.20 ETO01713.1 - 0.031 13.4 0.2 0.15 11.2 0.1 1.9 2 0 0 2 2 2 0 G-protein alpha subunit ABC_tran PF00005.27 ETO01713.1 - 0.036 14.6 0.6 0.054 14.0 0.5 1.6 1 1 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ETO01713.1 - 0.037 14.3 1.6 0.23 11.7 0.1 2.5 2 2 1 3 3 3 0 AAA domain AAA_16 PF13191.6 ETO01713.1 - 0.044 14.2 0.2 0.1 13.0 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain Microtub_bd PF16796.5 ETO01713.1 - 0.049 13.6 0.0 0.1 12.5 0.0 1.6 1 0 0 1 1 1 0 Microtubule binding IstB_IS21 PF01695.17 ETO01713.1 - 0.051 13.3 0.0 0.077 12.7 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein PduV-EutP PF10662.9 ETO01713.1 - 0.054 13.2 0.1 0.22 11.2 0.1 2.1 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Dynamin_N PF00350.23 ETO01713.1 - 0.055 13.5 1.1 0.14 12.2 1.1 1.9 1 1 0 1 1 1 0 Dynamin family Myosin_head PF00063.21 ETO01713.1 - 0.059 11.6 0.0 0.088 11.0 0.0 1.2 1 0 0 1 1 1 0 Myosin head (motor domain) TsaE PF02367.17 ETO01713.1 - 0.064 13.2 0.0 0.16 12.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RXLR PF16810.5 ETO01715.1 - 0.0018 18.7 2.7 0.0038 17.7 2.7 1.6 1 0 0 1 1 1 1 RXLR phytopathogen effector protein, Avirulence activity HNF-1_N PF04814.13 ETO01715.1 - 0.013 16.1 6.1 0.018 15.7 6.1 1.3 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus NYAP_C PF15452.6 ETO01715.1 - 0.075 12.9 2.6 0.11 12.3 2.6 1.2 1 0 0 1 1 1 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Mucin PF01456.17 ETO01715.1 - 0.1 12.6 29.4 0.15 12.1 29.4 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 ETO01715.1 - 0.18 9.9 7.9 0.22 9.6 7.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Med3 PF11593.8 ETO01715.1 - 0.49 9.5 13.8 0.63 9.2 13.8 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Radial_spoke PF04712.12 ETO01715.1 - 6.4 5.6 17.0 11 4.8 17.1 1.3 1 1 0 1 1 1 0 Radial spokehead-like protein DEAD PF00270.29 ETO01718.1 - 7e-23 81.3 0.0 8.9e-23 80.9 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO01718.1 - 0.00011 22.2 0.0 0.00014 22.0 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 ETO01718.1 - 0.095 12.0 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain Flavi_DEAD PF07652.14 ETO01718.1 - 0.15 12.0 0.1 3.3 7.7 0.0 2.3 2 1 1 3 3 3 0 Flavivirus DEAD domain zf-CCHC PF00098.23 ETO01719.1 - 0.01 15.9 1.1 0.01 15.9 1.1 1.9 2 0 0 2 2 2 0 Zinc knuckle DUF2314 PF10077.9 ETO01719.1 - 0.032 14.3 0.0 0.059 13.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2314) TLD PF07534.16 ETO01720.1 - 3.9e-13 49.8 1.9 5.7e-13 49.3 1.9 1.2 1 0 0 1 1 1 1 TLD PPR_1 PF12854.7 ETO01720.1 - 0.18 11.6 0.5 0.34 10.7 0.5 1.4 1 0 0 1 1 1 0 PPR repeat HEAT PF02985.22 ETO01722.1 - 0.087 13.1 0.0 0.25 11.7 0.0 1.8 2 0 0 2 2 2 0 HEAT repeat GH43_C PF16369.5 ETO01725.1 - 0.05 14.2 0.6 0.094 13.4 0.6 1.4 1 0 0 1 1 1 0 C-terminal lipocalin-like domain Lipoprotein_3 PF00938.17 ETO01725.1 - 0.37 11.0 2.7 0.74 10.0 0.6 2.1 2 0 0 2 2 2 0 Lipoprotein TPR_12 PF13424.6 ETO01726.1 - 1.1e-156 509.4 23.8 2.7e-24 85.2 0.1 8.0 1 1 6 9 9 9 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01726.1 - 1.5e-106 345.8 0.4 1.2e-11 44.1 0.0 12.0 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01726.1 - 2.5e-96 308.8 22.5 3.5e-09 36.0 0.0 11.3 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01726.1 - 1.6e-83 271.4 68.3 2.2e-09 36.7 0.4 11.9 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01726.1 - 1.3e-70 227.8 69.8 9.1e-10 38.0 0.7 11.4 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01726.1 - 1.2e-69 224.9 41.5 1.8e-07 30.7 0.2 11.4 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01726.1 - 9.3e-40 135.0 0.0 0.0011 19.5 0.0 9.6 9 2 0 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01726.1 - 5.6e-38 126.6 19.2 0.0038 17.5 0.1 12.2 11 1 0 11 11 11 8 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01726.1 - 7.1e-31 104.3 0.0 0.049 14.5 0.0 10.8 8 3 3 11 11 11 4 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO01726.1 - 1.2e-25 90.6 0.0 4.4e-08 32.9 0.0 4.0 1 1 3 4 4 4 4 MalT-like TPR region TPR_6 PF13174.6 ETO01726.1 - 1.4e-24 85.1 5.0 0.14 12.8 0.0 11.1 11 0 0 11 11 11 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01726.1 - 6.8e-21 73.7 89.0 3.5e-05 23.4 3.2 17.1 9 6 9 18 18 17 11 TPR repeat SNAP PF14938.6 ETO01726.1 - 6.2e-19 68.5 17.2 3.4e-06 26.7 0.6 5.8 1 1 2 5 5 5 5 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETO01726.1 - 1.2e-18 65.9 34.5 0.13 12.6 0.1 10.5 11 0 0 11 11 10 6 PPR repeat TPR_19 PF14559.6 ETO01726.1 - 3.4e-17 62.7 0.5 0.09 13.3 0.0 7.4 3 2 6 9 9 9 7 Tetratricopeptide repeat DUF5113 PF17140.4 ETO01726.1 - 4.4e-15 55.9 27.4 0.48 10.2 0.1 10.1 9 1 1 10 10 10 6 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO01726.1 - 1.8e-14 53.3 38.4 0.039 13.9 0.1 10.3 10 1 0 10 10 9 6 Tetratricopeptide repeat OrfA PF17495.2 ETO01726.1 - 2.5e-10 40.4 0.0 3.5 7.8 0.0 7.1 1 1 6 8 8 7 1 Vpr-like OrfA TPR_9 PF13371.6 ETO01726.1 - 4.9e-10 39.4 0.0 0.74 10.0 0.0 5.9 3 2 3 7 7 7 3 Tetratricopeptide repeat MIT PF04212.18 ETO01726.1 - 9.2e-10 38.5 47.1 0.36 10.9 0.3 10.5 9 1 1 10 10 10 4 MIT (microtubule interacting and transport) domain DUF4810 PF16068.5 ETO01726.1 - 1.1e-09 38.6 14.5 1.4 9.5 0.0 8.0 5 2 3 8 8 8 1 Domain of unknown function (DUF4810) RPN7 PF10602.9 ETO01726.1 - 2.5e-09 37.1 24.9 1 9.1 0.1 9.3 2 2 6 10 10 10 2 26S proteasome subunit RPN7 ANAPC3 PF12895.7 ETO01726.1 - 2.6e-09 37.2 25.3 0.05 13.8 0.2 7.0 1 1 7 9 9 9 4 Anaphase-promoting complex, cyclosome, subunit 3 DUF627 PF04781.12 ETO01726.1 - 4e-08 33.2 13.9 0.51 10.4 0.1 7.9 6 2 2 8 8 8 2 Protein of unknown function (DUF627) ChuX_HutX PF06228.13 ETO01726.1 - 5.6e-07 29.4 0.3 20 4.9 0.0 7.7 1 1 7 8 8 8 0 Haem utilisation ChuX/HutX Ten1_2 PF15490.6 ETO01726.1 - 4.3e-06 26.4 0.0 28 4.4 0.0 7.1 2 2 8 10 10 10 0 Telomere-capping, CST complex subunit UBA_6 PF18039.1 ETO01726.1 - 3e-05 23.8 0.6 32 4.6 0.0 6.6 8 1 1 9 9 6 0 UBA-like domain Mob_Pre PF01076.19 ETO01726.1 - 7.3e-05 22.7 18.2 0.27 11.0 0.7 5.8 2 2 4 7 7 7 3 Plasmid recombination enzyme bPH_3 PF14470.6 ETO01726.1 - 0.00012 22.3 10.4 2.6 8.5 0.1 6.3 2 1 5 8 8 8 1 Bacterial PH domain SHNi-TPR PF10516.9 ETO01726.1 - 0.00017 21.0 5.7 2.6 7.6 0.0 6.7 7 0 0 7 7 7 1 SHNi-TPR Mad3_BUB1_I PF08311.12 ETO01726.1 - 0.00032 20.7 20.6 3.8 7.5 0.1 8.8 10 0 0 10 10 9 1 Mad3/BUB1 homology region 1 TPR_15 PF13429.6 ETO01726.1 - 0.00055 19.2 0.3 7.1 5.7 0.0 5.0 4 2 1 5 5 5 0 Tetratricopeptide repeat UPF0223 PF05256.12 ETO01726.1 - 0.00093 19.5 17.4 3.6 8.0 0.1 7.5 2 2 5 8 8 8 1 Uncharacterised protein family (UPF0223) SERTA PF06031.13 ETO01726.1 - 0.0012 18.4 0.2 28 4.5 0.0 5.4 6 0 0 6 6 5 0 SERTA motif HTH_Bact PF18768.1 ETO01726.1 - 0.0051 16.4 26.7 20 4.9 0.1 10.9 10 2 0 10 10 10 0 Helix-turn-helix bacterial domain GvpK PF05121.12 ETO01726.1 - 0.011 15.7 0.3 63 3.7 0.0 5.2 7 1 0 7 7 4 0 Gas vesicle protein K ATP-synt_E_2 PF08112.11 ETO01726.1 - 0.018 15.3 33.2 3.6 7.9 0.1 9.1 9 0 0 9 9 8 0 ATP synthase epsilon subunit Sel1 PF08238.12 ETO01726.1 - 0.036 14.8 30.0 29 5.5 0.0 10.4 10 3 0 10 10 9 0 Sel1 repeat OEP PF02321.18 ETO01726.1 - 0.055 13.3 1.2 52 3.6 0.0 4.1 4 1 0 4 4 4 0 Outer membrane efflux protein FATC PF02260.20 ETO01726.1 - 0.2 11.5 1.6 1.4e+02 2.4 0.0 4.5 5 0 0 5 5 4 0 FATC domain CagS PF16707.5 ETO01726.1 - 0.42 10.6 21.7 2.2 8.3 0.4 6.2 1 1 8 9 9 9 0 Cag pathogenicity island protein S of Helicobacter pylori TPR_21 PF09976.9 ETO01726.1 - 0.42 10.3 12.8 36 4.0 0.1 6.4 2 1 2 7 7 7 0 Tetratricopeptide repeat-like domain TetR_C_19 PF17924.1 ETO01726.1 - 0.54 10.9 13.8 90 3.7 0.0 7.4 9 0 0 9 9 9 0 Tetracyclin repressor-like, C-terminal domain Med31 PF05669.12 ETO01726.1 - 0.58 10.2 5.2 9.3 6.3 0.2 3.3 2 1 0 3 3 2 0 SOH1 PPR_2 PF13041.6 ETO01726.1 - 1 9.6 14.2 91 3.4 0.0 7.5 8 0 0 8 8 8 0 PPR repeat family BAR_3 PF16746.5 ETO01726.1 - 2.2 7.9 19.6 31 4.2 0.1 7.3 3 2 3 7 7 7 0 BAR domain of APPL family Mis12 PF05859.12 ETO01727.1 - 0.0095 16.0 1.3 0.013 15.6 0.2 1.7 1 1 1 2 2 2 1 Mis12 protein DDHD PF02862.17 ETO01727.1 - 0.95 9.6 6.9 1.3 9.2 6.9 1.2 1 0 0 1 1 1 0 DDHD domain SMYLE_N PF18615.1 ETO01727.1 - 1.4 8.4 7.4 1.4 8.4 7.4 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain FGF-BP1 PF06473.12 ETO01727.1 - 1.4 8.7 11.9 2.3 8.0 11.9 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Zip PF02535.22 ETO01727.1 - 1.7 7.8 8.7 2 7.6 8.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 ETO01727.1 - 2.3 6.8 7.9 2.5 6.7 7.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4820 PF16091.5 ETO01727.1 - 3.8 6.8 10.3 5 6.4 10.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) SID-1_RNA_chan PF13965.6 ETO01727.1 - 4.4 5.6 6.5 5 5.4 6.1 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 AsnA PF03590.15 ETO01728.1 - 0.11 12.2 1.9 0.31 10.8 0.2 2.0 2 0 0 2 2 2 0 Aspartate-ammonia ligase HTH_AraC PF00165.23 ETO01728.1 - 0.12 12.6 0.1 1.7 8.8 0.0 2.3 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix proteins, AraC family DUF2776 PF10951.8 ETO01728.1 - 0.3 10.3 0.0 0.37 10.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2776) TLD PF07534.16 ETO01729.1 - 0.0019 18.4 0.3 0.85 9.8 0.0 2.2 2 0 0 2 2 2 2 TLD ALMT PF11744.8 ETO01732.1 - 0.82 8.4 26.4 0.23 10.3 15.9 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter TFIIA PF03153.13 ETO01732.1 - 7 6.5 40.9 10 6.0 40.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Agenet PF05641.12 ETO01733.1 - 0.1 13.1 0.0 0.19 12.2 0.0 1.4 1 0 0 1 1 1 0 Agenet domain Memo PF01875.17 ETO01734.1 - 3e-52 177.5 0.0 1.1e-51 175.6 0.0 1.8 2 0 0 2 2 2 1 Memo-like protein Dynactin_p62 PF05502.13 ETO01734.1 - 0.00016 20.6 0.5 0.00026 19.9 0.5 1.3 1 0 0 1 1 1 1 Dynactin p62 family SAPS PF04499.15 ETO01734.1 - 0.0079 15.0 2.1 0.0096 14.8 2.1 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein MCM_bind PF09739.9 ETO01734.1 - 0.036 12.5 5.4 0.061 11.8 5.4 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Nop14 PF04147.12 ETO01734.1 - 0.059 11.6 18.0 0.093 10.9 18.0 1.2 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 ETO01734.1 - 0.072 12.1 2.0 0.12 11.4 2.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) OAD_gamma PF04277.13 ETO01734.1 - 0.087 13.4 1.4 5.1 7.8 0.1 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Afi1 PF07792.12 ETO01734.1 - 0.14 12.6 17.7 0.22 12.0 16.1 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_Rpc4 PF05132.14 ETO01734.1 - 2.6 8.5 7.9 0.21 12.0 1.3 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 RRN3 PF05327.11 ETO01734.1 - 4.1 5.8 19.7 7.1 5.0 19.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Presenilin PF01080.17 ETO01734.1 - 7.2 5.3 7.4 14 4.3 7.4 1.4 1 0 0 1 1 1 0 Presenilin Astro_capsid_p PF12226.8 ETO01734.1 - 8.6 5.4 19.2 16 4.5 19.2 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Zip PF02535.22 ETO01734.1 - 10 5.3 7.2 1.8 7.7 3.8 1.4 2 0 0 2 2 2 0 ZIP Zinc transporter SpoIIIAH PF12685.7 ETO01737.1 - 0.043 13.7 3.6 0.061 13.2 3.6 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Presenilin PF01080.17 ETO01737.1 - 3.6 6.2 4.0 4.8 5.8 4.0 1.1 1 0 0 1 1 1 0 Presenilin Slx4 PF09494.10 ETO01738.1 - 0.058 13.3 0.5 0.14 12.1 0.5 1.6 1 0 0 1 1 1 0 Slx4 endonuclease TPR_12 PF13424.6 ETO01739.1 - 1.6e-18 66.8 0.1 3.9e-14 52.7 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01739.1 - 4.9e-15 54.9 0.1 2.1e-09 37.0 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01739.1 - 6e-10 38.5 4.9 0.00014 21.5 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01739.1 - 5.6e-09 35.4 1.2 0.0012 18.8 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01739.1 - 2.6e-08 33.5 5.5 0.00071 19.6 0.7 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01739.1 - 3.7e-07 30.1 0.4 0.034 14.5 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01739.1 - 1.9e-06 27.5 0.2 0.00075 19.4 0.0 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat PPR PF01535.20 ETO01739.1 - 0.00058 19.9 1.3 0.0063 16.7 0.1 2.3 2 0 0 2 2 2 1 PPR repeat Cohesin_load PF10345.9 ETO01739.1 - 0.00066 18.3 4.4 0.00066 18.3 4.4 1.7 1 1 1 2 2 2 1 Cohesin loading factor TPR_21 PF09976.9 ETO01739.1 - 0.0072 16.1 0.2 0.051 13.3 0.2 2.0 1 1 0 1 1 1 1 Tetratricopeptide repeat-like domain DUF5113 PF17140.4 ETO01739.1 - 0.023 14.5 1.4 0.86 9.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 ETO01739.1 - 0.068 12.6 0.1 1.2 8.7 0.0 2.3 2 0 0 2 2 2 0 SHNi-TPR TPR_MalT PF17874.1 ETO01739.1 - 0.072 12.5 0.0 0.086 12.2 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region AAA PF00004.29 ETO01740.1 - 0.0012 19.3 0.0 0.0038 17.7 0.0 1.9 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ETO01740.1 - 0.045 13.0 0.2 1.3 8.3 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin AAA_5 PF07728.14 ETO01740.1 - 0.078 13.0 0.0 0.27 11.2 0.0 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ETO01740.1 - 0.12 12.4 0.1 0.55 10.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO01740.1 - 0.13 12.8 0.0 0.21 12.1 0.0 1.4 1 0 0 1 1 1 0 ABC transporter Flavodoxin_NdrI PF07972.11 ETO01741.1 - 0.063 13.4 0.2 0.47 10.6 0.0 2.5 2 1 0 2 2 2 0 NrdI Flavodoxin like RuvA_C PF07499.13 ETO01742.1 - 0.084 13.3 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 RuvA, C-terminal domain zf-C3HC4_3 PF13920.6 ETO01744.1 - 0.031 14.1 10.6 0.031 14.1 10.6 1.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO01744.1 - 0.29 11.0 10.4 0.57 10.1 10.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO01744.1 - 0.67 10.3 11.4 1.4 9.3 11.4 1.6 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 ETO01744.1 - 1.2 9.2 10.4 2.2 8.3 10.4 1.4 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO01744.1 - 3.9 7.4 12.9 2 8.3 10.5 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ion_trans PF00520.31 ETO01745.1 - 1.5e-08 34.1 6.0 2.1e-08 33.7 5.3 1.6 1 1 0 1 1 1 1 Ion transport protein Kelch_4 PF13418.6 ETO01746.1 - 0.00065 19.6 0.5 0.036 14.1 0.1 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO01746.1 - 0.0017 18.5 6.1 0.76 10.2 0.2 3.8 5 0 0 5 5 5 2 Kelch motif OAD_gamma PF04277.13 ETO01746.1 - 0.003 18.1 0.4 0.0061 17.1 0.4 1.5 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain Kelch_5 PF13854.6 ETO01746.1 - 0.0065 16.4 4.2 0.57 10.2 2.2 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO01746.1 - 0.026 14.8 0.0 5.1 7.5 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain PDR_CDR PF06422.12 ETO01746.1 - 0.075 12.9 0.9 0.87 9.5 0.2 2.4 2 0 0 2 2 2 0 CDR ABC transporter Adaptin_N PF01602.20 ETO01747.1 - 3.4e-09 35.8 0.2 1.4e-06 27.2 0.0 2.2 2 0 0 2 2 2 2 Adaptin N terminal region VWA_2 PF13519.6 ETO01749.1 - 1.7e-06 28.6 0.0 6e-06 26.9 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain DUF87 PF01935.17 ETO01749.1 - 0.026 14.6 4.2 0.11 12.6 0.5 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain DrsE PF02635.15 ETO01749.1 - 0.14 12.5 0.7 3.7 7.9 0.1 3.0 3 1 0 3 3 3 0 DsrE/DsrF-like family HEAT_2 PF13646.6 ETO01750.1 - 2.2e-37 127.3 9.7 4.1e-09 36.7 0.0 6.1 1 1 3 5 5 5 5 HEAT repeats HEAT PF02985.22 ETO01750.1 - 2e-18 64.9 3.2 0.053 13.8 0.0 9.7 10 0 0 10 10 10 4 HEAT repeat Cnd1 PF12717.7 ETO01750.1 - 3.1e-14 53.3 9.8 7.1e-05 22.9 0.2 6.6 1 1 4 6 6 6 4 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETO01750.1 - 5.9e-12 44.9 16.2 0.0066 15.1 4.0 4.4 2 1 2 4 4 4 4 Adaptin N terminal region HEAT_EZ PF13513.6 ETO01750.1 - 6e-07 29.8 11.5 0.1 13.1 0.1 7.8 6 2 3 9 9 9 2 HEAT-like repeat HEAT_PBS PF03130.16 ETO01750.1 - 9.4e-05 22.7 7.6 9.1 7.3 0.1 7.2 7 0 0 7 7 7 2 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO01750.1 - 0.002 18.7 0.3 19 5.9 0.0 4.8 3 1 1 4 4 4 1 Vacuolar 14 Fab1-binding region Arm PF00514.23 ETO01750.1 - 0.019 15.0 1.6 1 9.5 0.1 4.2 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat DUF3385 PF11865.8 ETO01750.1 - 0.024 14.6 6.4 7.2 6.5 0.0 5.4 4 2 1 5 5 5 0 Domain of unknown function (DUF3385) DUF294 PF03445.13 ETO01751.1 - 1e-08 35.1 0.0 4.8e-08 32.9 0.0 2.1 2 0 0 2 2 2 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 ETO01751.1 - 0.035 13.9 0.0 0.078 12.8 0.0 1.6 1 0 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain Ank_2 PF12796.7 ETO01752.1 - 2.7e-20 72.8 2.2 9.9e-10 38.9 0.1 2.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO01752.1 - 1.4e-15 57.4 0.1 9.4e-07 29.3 0.2 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO01752.1 - 6.8e-10 38.3 0.0 1.5e-05 25.0 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO01752.1 - 2.4e-08 34.1 0.1 5.3e-07 29.8 0.2 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO01752.1 - 3.4e-05 24.1 0.1 0.00071 19.9 0.1 2.6 3 0 0 3 3 3 1 Ankyrin repeat MIase PF02426.16 ETO01752.1 - 0.11 12.7 0.0 0.41 10.8 0.0 1.9 1 1 1 2 2 2 0 Muconolactone delta-isomerase Ras PF00071.22 ETO01755.1 - 4.5e-21 75.1 0.8 2.1e-19 69.7 0.6 2.8 1 1 1 2 2 2 1 Ras family Peptidase_C14 PF00656.22 ETO01755.1 - 6.3e-14 52.5 1.0 1.6e-13 51.2 1.0 1.7 1 0 0 1 1 1 1 Caspase domain Ribosomal_L18p PF00861.22 ETO01755.1 - 0.24 11.8 1.6 9.2 6.7 0.0 2.8 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast AAA_assoc_C PF09821.9 ETO01755.1 - 0.65 10.5 7.5 3 8.4 0.2 3.7 4 0 0 4 4 4 0 C-terminal AAA-associated domain AAA_22 PF13401.6 ETO01755.1 - 1 9.6 4.3 10 6.4 0.0 3.8 3 1 1 4 4 4 0 AAA domain Kelch_1 PF01344.25 ETO01756.1 - 3.1e-05 23.5 0.4 0.0014 18.2 0.2 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO01756.1 - 6.2e-05 22.8 6.0 0.0087 16.0 0.3 4.1 4 1 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO01756.1 - 0.0024 18.1 1.7 5.9 7.3 0.0 3.8 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO01756.1 - 0.0033 17.4 0.2 0.058 13.4 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01756.1 - 0.0041 17.1 1.5 1.7 8.7 0.2 3.7 4 0 0 4 4 4 2 Kelch motif SCAB_CC PF16712.5 ETO01757.1 - 0.016 15.1 2.4 0.041 13.7 2.4 1.6 1 0 0 1 1 1 0 Coiled-coil regions of plant-specific actin-binding protein FAM176 PF14851.6 ETO01757.1 - 3.1 7.5 7.3 8.4 6.0 7.3 1.7 1 0 0 1 1 1 0 FAM176 family Ribosomal_S4e PF00900.20 ETO01758.1 - 1e-29 102.2 0.0 1e-29 102.2 0.0 2.8 4 0 0 4 4 4 1 Ribosomal family S4e 40S_S4_C PF16121.5 ETO01758.1 - 1.2e-19 69.7 0.1 2.9e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus S4 PF01479.25 ETO01758.1 - 3.6e-05 23.4 0.5 0.00011 21.9 0.1 2.0 2 0 0 2 2 2 1 S4 domain KOW PF00467.29 ETO01758.1 - 0.00035 20.4 3.4 0.0011 18.8 3.4 1.9 1 0 0 1 1 1 1 KOW motif NAD_binding_1 PF00175.21 ETO01758.1 - 0.031 14.9 0.5 5 7.8 0.2 3.0 3 0 0 3 3 3 0 Oxidoreductase NAD-binding domain PPTA PF01239.22 ETO01759.1 - 4.3e-34 115.2 10.9 1e-09 37.8 0.4 4.4 4 0 0 4 4 4 4 Protein prenyltransferase alpha subunit repeat Retrotran_gag_3 PF14244.6 ETO01759.1 - 0.023 14.5 0.8 17 5.3 0.0 3.4 3 0 0 3 3 3 0 gag-polypeptide of LTR copia-type AvrM-A PF18241.1 ETO01759.1 - 0.13 12.6 4.9 0.21 12.0 4.9 1.3 1 0 0 1 1 1 0 Flax-rust effector AvrM-A AAT PF03417.16 ETO01760.1 - 2.3e-20 73.2 0.0 4.4e-20 72.3 0.0 1.4 1 0 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase M_domain PF12938.7 ETO01761.1 - 0.0056 16.5 6.9 0.0056 16.5 6.9 1.9 1 1 1 2 2 2 1 M domain of GW182 Geminin PF07412.12 ETO01761.1 - 2.5 7.8 10.8 7.6 6.2 9.5 2.1 1 1 1 2 2 2 0 Geminin Myb_DNA-bind_6 PF13921.6 ETO01762.1 - 0.0038 17.5 2.5 0.012 15.9 2.5 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Chromo PF00385.24 ETO01762.1 - 0.087 12.7 2.3 0.34 10.8 0.6 2.7 1 1 1 2 2 2 0 Chromo (CHRromatin Organisation MOdifier) domain DUF4239 PF14023.6 ETO01762.1 - 0.78 9.4 2.1 1.1 8.9 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) WD-3 PF09765.9 ETO01762.1 - 1.2 8.4 8.7 0.045 13.1 0.5 2.1 2 0 0 2 2 2 0 WD-repeat region TPR_12 PF13424.6 ETO01764.1 - 2.8e-78 258.2 22.7 4.6e-19 68.5 0.2 6.1 1 1 5 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01764.1 - 5.9e-45 149.3 38.5 3.1e-08 33.1 0.7 9.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01764.1 - 2e-42 141.9 4.5 1.2e-08 34.5 0.1 8.3 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01764.1 - 4.4e-38 126.5 16.5 3.9e-06 26.5 0.1 8.2 7 1 1 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01764.1 - 1.9e-31 105.6 29.0 7.7e-06 25.6 0.4 9.2 8 1 1 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01764.1 - 1.7e-29 99.5 39.5 2.6e-05 24.1 0.6 9.0 8 1 1 9 9 9 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01764.1 - 8.2e-11 41.5 6.3 4.4 7.9 0.6 8.4 8 1 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01764.1 - 3.6e-10 39.8 0.0 1.8 9.6 0.0 6.8 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01764.1 - 9.2e-10 39.0 0.0 0.4 11.4 0.0 5.6 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01764.1 - 1.3e-09 38.1 0.4 0.75 10.6 0.0 7.4 9 0 0 9 9 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01764.1 - 1.5e-09 37.4 38.5 0.017 14.8 1.5 9.3 10 3 2 12 12 11 4 TPR repeat TPR_MalT PF17874.1 ETO01764.1 - 3.4e-08 33.3 0.0 0.00029 20.3 0.0 2.2 1 1 1 2 2 2 2 MalT-like TPR region DUF5113 PF17140.4 ETO01764.1 - 3.4e-05 23.7 17.9 0.48 10.2 0.0 6.6 7 1 1 8 8 7 2 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 ETO01764.1 - 0.00055 19.3 5.9 3.1 7.3 0.0 5.8 5 0 0 5 5 5 1 SHNi-TPR DUF3856 PF12968.7 ETO01764.1 - 0.00058 19.9 0.8 0.17 12.0 0.1 3.1 2 1 0 2 2 2 1 Domain of Unknown Function (DUF3856) TPR_19 PF14559.6 ETO01764.1 - 0.0031 18.0 5.0 7 7.2 0.0 4.3 3 1 2 5 5 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO01764.1 - 0.0044 17.7 7.8 6.1 7.7 0.1 5.7 6 0 0 6 6 6 1 Sel1 repeat DUF4810 PF16068.5 ETO01764.1 - 0.037 14.6 4.7 3.9 8.1 0.5 4.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4810) HTH_Bact PF18768.1 ETO01764.1 - 0.15 11.7 17.5 5.9 6.6 0.1 7.4 8 0 0 8 8 8 0 Helix-turn-helix bacterial domain DUF3922 PF13059.6 ETO01764.1 - 0.3 11.6 6.6 14 6.2 0.2 4.5 4 1 0 4 4 3 0 Protein of unknown function (DUF3992) SPO22 PF08631.10 ETO01764.1 - 0.37 10.2 10.5 0.34 10.3 2.0 3.9 2 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 ETO01764.1 - 0.4 10.7 18.5 1 9.4 0.5 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO01764.1 - 0.41 10.3 19.5 0.15 11.8 2.1 4.2 2 1 2 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2225) Phage_Treg PF04761.12 ETO01764.1 - 1.9 8.7 15.1 1.4 9.1 0.2 6.0 7 0 0 7 7 7 0 Lactococcus bacteriophage putative transcription regulator Mob_Pre PF01076.19 ETO01764.1 - 4.2 7.1 19.6 0.042 13.7 0.9 3.8 2 1 0 3 3 3 0 Plasmid recombination enzyme PPR PF01535.20 ETO01764.1 - 7.8 7.0 8.4 12 6.4 0.0 5.4 7 0 0 7 7 5 0 PPR repeat KNOX2 PF03791.13 ETO01765.1 - 0.018 14.6 0.5 0.044 13.3 0.3 1.7 2 0 0 2 2 2 0 KNOX2 domain DUF4061 PF13270.6 ETO01766.1 - 0.0074 16.6 1.0 0.0074 16.6 1.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4061) ACP_PD PF04336.12 ETO01766.1 - 0.017 15.6 0.4 0.037 14.4 0.2 1.6 1 1 1 2 2 2 0 Acyl carrier protein phosphodiesterase TINF2_N PF14973.6 ETO01767.1 - 0.054 13.8 2.5 0.07 13.5 2.5 1.3 1 1 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus PDEase_I PF00233.19 ETO01768.1 - 2.5e-36 125.6 5.4 4.5e-36 124.8 5.4 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase DUF2457 PF10446.9 ETO01768.1 - 0.27 10.3 7.9 0.46 9.6 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RXT2_N PF08595.11 ETO01768.1 - 0.49 10.4 5.0 1.1 9.2 5.0 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal RNA_pol_3_Rpc31 PF11705.8 ETO01768.1 - 0.74 10.0 9.6 1.3 9.2 9.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 FYDLN_acid PF09538.10 ETO01768.1 - 0.8 10.4 8.0 1.5 9.6 8.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DNA_pol_phi PF04931.13 ETO01768.1 - 0.9 7.6 8.5 1.2 7.1 8.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO01768.1 - 3.8 6.8 7.5 5.8 6.1 7.5 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO01768.1 - 5.9 7.4 14.0 1.6 9.1 9.3 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Tctex-1 PF03645.13 ETO01769.1 - 0.16 12.2 0.5 1.3 9.3 0.5 2.2 1 1 0 1 1 1 0 Tctex-1 family Mitoc_mL59 PF18126.1 ETO01769.1 - 1.4 9.2 6.4 0.2 11.9 2.0 1.9 2 1 0 2 2 2 0 Mitochondrial ribosomal protein mL59 Cue1_U7BR PF18499.1 ETO01770.1 - 0.15 12.1 1.9 0.9 9.6 0.1 2.7 2 2 1 3 3 3 0 Ubc7p-binding region of Cue1 DUF908 PF06012.12 ETO01771.1 - 0.05 13.0 0.1 0.05 13.0 0.1 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF908) GET2 PF08690.10 ETO01771.1 - 5.5 6.6 17.8 7.1 6.2 17.8 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Ndc1_Nup PF09531.10 ETO01771.1 - 8.3 5.0 9.3 9.6 4.8 9.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup APA3_viroporin PF11289.8 ETO01772.1 - 0.014 15.0 0.2 0.032 13.8 0.2 1.7 1 1 0 1 1 1 0 Coronavirus accessory protein 3a Atx10homo_assoc PF09759.9 ETO01774.1 - 0.0084 16.1 0.1 0.01 15.8 0.1 1.1 1 0 0 1 1 1 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 ETO01777.1 - 0.00025 21.0 0.0 0.0021 18.0 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ETO01777.1 - 0.0057 16.7 1.9 0.028 14.4 0.1 2.6 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain V-ATPase_H_C PF11698.8 ETO01777.1 - 0.016 15.3 5.6 0.19 11.9 0.0 3.7 3 2 1 4 4 4 0 V-ATPase subunit H DUF3361 PF11841.8 ETO01777.1 - 0.038 13.9 1.9 0.17 11.9 1.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) DUF1746 PF08508.10 ETO01777.1 - 0.35 11.2 4.3 1.2 9.5 1.8 2.5 1 1 1 2 2 2 0 Fungal domain of unknown function (DUF1746) ABC2_membrane PF01061.24 ETO01778.1 - 1.7e-16 60.3 38.0 2.8e-13 49.8 38.0 2.1 1 1 0 1 1 1 1 ABC-2 type transporter PDR_CDR PF06422.12 ETO01778.1 - 0.17 11.8 0.2 0.17 11.8 0.2 2.8 2 0 0 2 2 2 0 CDR ABC transporter Intein_splicing PF14890.6 ETO01779.1 - 0.053 13.5 2.9 0.14 12.2 0.0 2.2 2 0 0 2 2 2 0 Intein splicing domain Hint PF01079.20 ETO01779.1 - 0.089 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Hint module TMF_TATA_bd PF12325.8 ETO01780.1 - 0.0032 17.7 0.7 0.0059 16.8 0.7 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding RNA_pol_Rpb2_2 PF04561.14 ETO01780.1 - 0.0098 15.5 0.7 0.013 15.1 0.7 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RecQ_Zn_bind PF16124.5 ETO01780.1 - 0.12 13.1 4.9 0.15 12.8 1.6 2.4 1 1 0 2 2 2 0 RecQ zinc-binding DUF16 PF01519.16 ETO01780.1 - 0.13 12.8 5.6 0.48 10.9 5.6 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Kelch_6 PF13964.6 ETO01781.1 - 0.011 15.9 0.0 0.03 14.6 0.0 1.7 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO01781.1 - 0.096 12.7 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Kelch motif MRP-S33 PF08293.11 ETO01782.1 - 0.0064 16.7 0.2 0.0095 16.1 0.2 1.2 1 0 0 1 1 1 1 Mitochondrial ribosomal subunit S27 Tai4 PF16695.5 ETO01782.1 - 0.0079 16.7 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 Type VI secretion system (T6SS), amidase immunity protein Cys_rich_VLP PF14194.6 ETO01782.1 - 0.032 14.3 1.3 0.055 13.6 1.3 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP SF3A3 PF16837.5 ETO01783.1 - 0.12 12.9 1.4 0.19 12.3 0.3 1.9 1 1 1 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Kelch_4 PF13418.6 ETO01784.1 - 3.3e-06 27.0 0.1 8.3e-05 22.5 0.0 2.4 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO01784.1 - 4.9e-06 26.3 1.7 0.0011 18.8 0.5 2.7 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO01784.1 - 2.9e-05 23.5 0.6 2.9e-05 23.5 0.6 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO01784.1 - 0.0017 18.6 0.0 0.012 15.9 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01784.1 - 0.0061 16.5 0.3 0.12 12.4 0.8 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO01784.1 - 0.013 15.7 1.7 0.29 11.5 0.8 2.5 2 0 0 2 2 2 0 Kelch motif Ran-binding PF05508.11 ETO01789.1 - 0.025 13.6 0.6 0.025 13.6 0.6 1.1 1 0 0 1 1 1 0 RanGTP-binding protein Herpes_U59 PF04529.12 ETO01790.1 - 0.0064 15.6 0.0 0.012 14.7 0.0 1.4 1 0 0 1 1 1 1 Herpesvirus U59 protein SPOB_ab PF14682.6 ETO01791.1 - 0.045 13.8 1.3 6.9 6.8 0.3 2.9 2 0 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal DDE_Tnp_IS240 PF13610.6 ETO01791.1 - 0.058 13.6 0.4 0.19 11.9 0.1 2.0 2 0 0 2 2 2 0 DDE domain Rx_N PF18052.1 ETO01791.1 - 0.13 12.5 0.9 0.41 10.9 0.9 1.8 1 0 0 1 1 1 0 Rx N-terminal domain Ribosomal_L19e PF01280.20 ETO01791.1 - 0.17 12.0 1.7 0.37 10.8 0.3 2.1 2 0 0 2 2 2 0 Ribosomal protein L19e DUF1690 PF07956.11 ETO01791.1 - 0.97 9.8 5.4 0.097 13.1 0.6 1.9 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Lipoprotein_3 PF00938.17 ETO01792.1 - 0.35 11.1 3.1 3.5 7.9 0.9 2.4 2 0 0 2 2 2 0 Lipoprotein Kelch_6 PF13964.6 ETO01793.1 - 0.00039 20.6 0.1 0.0067 16.7 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO01793.1 - 0.0012 18.8 0.0 0.0024 17.8 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01793.1 - 0.0032 17.0 0.0 0.007 15.9 0.0 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 ETO01793.1 - 0.042 13.9 0.1 0.17 11.9 0.0 2.0 2 0 0 2 2 2 0 Kelch motif GGDEF PF00990.21 ETO01794.1 - 0.0026 17.5 0.2 0.0047 16.7 0.1 1.5 2 0 0 2 2 2 1 Diguanylate cyclase, GGDEF domain MMU163 PF17119.5 ETO01795.1 - 0.6 9.2 5.5 0.7 9.0 5.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF1168 PF06658.12 ETO01795.1 - 2.1 8.2 13.2 3.2 7.6 13.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Presenilin PF01080.17 ETO01795.1 - 8.3 5.0 5.6 8.1 5.1 5.6 1.0 1 0 0 1 1 1 0 Presenilin DUF711 PF05167.12 ETO01796.1 - 0.079 11.9 0.1 0.098 11.5 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) DUF2877 PF11392.8 ETO01796.1 - 0.45 11.3 1.0 1.8 9.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) PRE_C2HC PF07530.11 ETO01796.1 - 0.61 10.2 5.4 0.79 9.9 0.1 3.2 4 0 0 4 4 4 0 Associated with zinc fingers CdiI PF07262.11 ETO01796.1 - 1.1 9.0 12.3 0.023 14.5 4.7 2.1 3 0 0 3 3 3 0 CDI immunity protein Tristanin_u2 PF16638.5 ETO01797.1 - 0.22 12.4 1.2 0.42 11.4 0.1 2.0 2 1 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers U-box PF04564.15 ETO01799.1 - 2.4e-13 50.0 1.0 1.1e-12 47.9 0.0 2.7 2 1 0 2 2 2 1 U-box domain zf-NOSIP PF15906.5 ETO01799.1 - 0.03 14.4 0.1 0.11 12.6 0.0 2.0 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein DUF4570 PF15134.6 ETO01799.1 - 0.18 11.8 5.7 0.23 11.5 3.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4570) MTBP_C PF14920.6 ETO01800.1 - 0.082 12.6 7.7 0.097 12.4 7.7 1.1 1 0 0 1 1 1 0 MDM2-binding PAP1 PF08601.10 ETO01800.1 - 2.2 7.9 19.3 2.3 7.9 19.3 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 WD40 PF00400.32 ETO01801.1 - 2e-36 123.3 25.0 5.2e-07 30.2 0.8 7.0 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01801.1 - 8.1e-09 35.7 1.1 0.17 12.2 0.0 4.5 2 2 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01801.1 - 2.9e-07 29.5 6.7 0.0035 16.1 0.2 4.7 1 1 4 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO01801.1 - 1.2e-06 28.0 10.6 0.0024 17.3 0.4 4.2 2 2 1 4 4 4 2 WD40-like domain DCX PF03607.17 ETO01801.1 - 0.1 12.7 1.2 5.8 7.1 0.0 3.4 4 0 0 4 4 4 0 Doublecortin Ank_2 PF12796.7 ETO01802.1 - 9.7e-10 38.9 0.1 2.2e-09 37.7 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO01802.1 - 3.9e-09 36.0 0.1 0.0008 19.7 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ETO01802.1 - 1.7e-08 34.8 0.1 1.5e-06 28.6 0.1 3.0 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO01802.1 - 3.3e-07 30.4 0.1 0.0034 17.8 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO01802.1 - 0.017 15.4 7.2 0.019 15.3 0.1 3.4 2 1 2 4 4 4 0 Ankyrin repeats (many copies) WD40 PF00400.32 ETO01803.1 - 3.5e-33 113.1 25.0 3.9e-07 30.7 0.2 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO01803.1 - 1.6e-10 40.3 4.2 0.083 11.5 1.2 4.1 1 1 3 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01803.1 - 3.2e-10 40.1 1.9 0.071 13.4 0.0 5.3 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain ASFV_360 PF01671.16 ETO01803.1 - 0.01 15.3 1.4 0.027 14.0 1.4 1.7 1 0 0 1 1 1 0 African swine fever virus multigene family 360 protein Tub_N PF16322.5 ETO01804.1 - 0.13 12.6 8.4 0.022 15.2 3.4 2.1 2 0 0 2 2 2 0 Tubby N-terminal GOLD_2 PF13897.6 ETO01804.1 - 0.2 12.2 2.2 0.54 10.7 2.2 1.7 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking WRNPLPNID PF15017.6 ETO01804.1 - 5.7 7.9 10.6 62 4.6 6.8 2.7 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box OKR_DC_1_N PF03709.15 ETO01806.1 - 0.12 12.6 0.0 1.7 8.9 0.0 2.1 2 0 0 2 2 2 0 Orn/Lys/Arg decarboxylase, N-terminal domain Tim54 PF11711.8 ETO01807.1 - 0.014 14.3 0.6 0.016 14.1 0.6 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Npun_R1517 PF18068.1 ETO01808.1 - 0.014 15.7 0.3 0.016 15.5 0.3 1.2 1 0 0 1 1 1 0 Npun R1517 Peptidase_C14 PF00656.22 ETO01809.1 - 1.4e-15 58.0 0.2 2.9e-15 56.9 0.2 1.5 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO01809.1 - 5.3e-05 23.1 2.9 0.0017 18.3 0.0 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO01809.1 - 0.00063 19.9 2.8 0.51 10.7 0.1 4.5 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 ETO01809.1 - 0.0024 17.8 0.1 0.14 12.2 0.1 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO01809.1 - 0.0045 17.3 0.3 0.024 14.9 0.0 2.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO01809.1 - 0.024 14.2 0.2 0.36 10.5 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO01809.1 - 0.2 11.7 1.0 2.4 8.3 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Cys_knot PF00007.22 ETO01810.1 - 0.23 11.7 5.3 0.35 11.2 5.3 1.4 1 0 0 1 1 1 0 Cystine-knot domain PP2C PF00481.21 ETO01811.1 - 1.9e-09 37.5 0.0 3.2e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ETO01811.1 - 0.048 13.6 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) DUF2040 PF09745.9 ETO01812.1 - 2.4e-27 95.4 19.4 2.4e-27 95.4 19.4 3.5 3 0 0 3 3 3 1 Coiled-coil domain-containing protein 55 (DUF2040) TP2 PF01254.18 ETO01812.1 - 0.0041 17.7 16.7 0.0041 17.7 16.7 3.1 4 0 0 4 4 4 1 Nuclear transition protein 2 DCB PF16213.5 ETO01813.1 - 0.00038 20.2 0.1 0.00053 19.7 0.1 1.2 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Condensin2nSMC PF12422.8 ETO01813.1 - 0.0074 16.5 0.3 0.014 15.6 0.3 1.6 1 1 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit RIFIN PF02009.16 ETO01814.1 - 0.015 15.2 7.7 0.023 14.6 7.7 1.2 1 0 0 1 1 1 0 Rifin MMR1 PF08505.10 ETO01814.1 - 0.043 14.1 24.1 0.048 13.9 24.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF1189 PF06691.11 ETO01814.1 - 0.044 13.3 0.3 0.044 13.3 0.3 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF1189) DUF3671 PF12420.8 ETO01814.1 - 0.066 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function LAP1C PF05609.12 ETO01814.1 - 0.23 10.5 22.8 0.29 10.2 22.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neurensin PF14927.6 ETO01814.1 - 0.3 10.8 0.0 0.3 10.8 0.0 1.8 2 1 0 2 2 2 0 Neurensin FUSC PF04632.12 ETO01814.1 - 0.7 8.4 12.0 0.92 8.0 12.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family TraG_N PF07916.11 ETO01814.1 - 0.74 8.6 15.3 0.99 8.2 15.3 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Zip PF02535.22 ETO01814.1 - 0.81 8.8 10.5 1.6 7.9 10.5 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter Patched PF02460.18 ETO01814.1 - 0.9 7.5 7.1 1.3 7.0 7.1 1.3 1 1 0 1 1 1 0 Patched family Hid1 PF12722.7 ETO01814.1 - 1 7.4 23.8 1.2 7.1 23.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GET2 PF08690.10 ETO01814.1 - 4.6 6.8 24.2 6.2 6.4 24.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 TMEM154 PF15102.6 ETO01814.1 - 5.5 6.9 8.4 0.46 10.4 0.1 2.2 2 0 0 2 2 2 0 TMEM154 protein family Suf PF05843.14 ETO01814.1 - 5.6 6.9 26.2 1.8 8.5 23.5 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 ETO01814.1 - 7.5 6.4 51.8 13 5.7 51.8 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Peptidase_C14 PF00656.22 ETO01816.1 - 3e-13 50.3 0.5 3.9e-13 49.9 0.5 1.1 1 0 0 1 1 1 1 Caspase domain TFIIS_M PF07500.14 ETO01817.1 - 0.031 14.8 3.8 0.12 12.9 1.4 2.2 1 1 1 2 2 2 0 Transcription factor S-II (TFIIS), central domain zf-C3HC4_3 PF13920.6 ETO01820.1 - 1.8e-14 53.3 11.0 2.8e-14 52.7 11.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO01820.1 - 1.8e-07 30.9 12.1 3.2e-07 30.1 12.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 WWE PF02825.20 ETO01820.1 - 6.5e-06 26.6 0.3 1.4e-05 25.6 0.3 1.6 1 0 0 1 1 1 1 WWE domain zf-RING_5 PF14634.6 ETO01820.1 - 0.012 15.5 13.3 0.025 14.6 13.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_2 PF13639.6 ETO01820.1 - 0.014 15.8 14.2 0.025 14.9 14.2 1.5 1 0 0 1 1 1 0 Ring finger domain Csc2 PF18320.1 ETO01820.1 - 0.015 14.3 0.7 0.02 13.9 0.7 1.1 1 0 0 1 1 1 0 Csc2 Crispr CS PF04969.16 ETO01821.1 - 0.0086 17.1 2.2 0.01 16.8 0.3 2.0 2 0 0 2 2 2 1 CS domain WD40 PF00400.32 ETO01823.1 - 7.5e-20 70.9 11.7 3.6e-08 33.9 0.6 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO01823.1 - 1.4e-06 27.3 2.3 0.00012 20.9 0.5 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO01823.1 - 0.00013 21.7 0.0 0.2 11.5 0.0 2.7 2 0 0 2 2 2 2 ATP-dependent RecD-like DNA helicase SH3 domain WD40_like PF17005.5 ETO01823.1 - 0.00088 18.7 0.1 0.0019 17.6 0.1 1.6 1 0 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO01823.1 - 0.0049 17.1 0.1 0.021 15.1 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nudix_N_2 PF14803.6 ETO01826.1 - 0.097 12.6 0.2 0.097 12.6 0.2 2.1 2 0 0 2 2 2 0 Nudix N-terminal DUF4718 PF15842.5 ETO01827.1 - 0.36 10.6 3.3 0.65 9.8 3.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4718) DUF4718 PF15842.5 ETO01828.1 - 0.12 12.2 0.2 0.13 12.0 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) TetR_C_23 PF17931.1 ETO01831.1 - 0.056 13.6 0.3 0.08 13.1 0.3 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain DrrA_P4M PF14860.6 ETO01831.1 - 0.17 11.8 4.9 0.31 10.9 2.6 2.2 1 1 1 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain Peptidase_M1 PF01433.20 ETO01832.1 - 4e-19 69.1 0.0 5.6e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ETO01832.1 - 2.5e-12 47.3 0.7 5.4e-10 39.8 0.1 2.3 1 1 1 2 2 2 2 Peptidase M1 N-terminal domain RNA_bind PF08675.11 ETO01832.1 - 0.13 12.3 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 RNA binding domain WD40 PF00400.32 ETO01836.1 - 5.1e-12 46.1 3.2 8e-06 26.5 0.6 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01836.1 - 0.0019 18.5 0.1 1.9 8.8 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01836.1 - 0.0023 16.6 0.2 0.71 8.5 0.1 1.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF1837 PF08878.11 ETO01837.1 - 0.076 12.8 8.4 0.16 11.7 8.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1837) DUF3561 PF12084.8 ETO01838.1 - 0.2 11.7 0.0 0.2 11.7 0.0 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF3561) Hydrolase_3 PF08282.12 ETO01839.1 - 0.0076 16.0 2.3 0.013 15.3 2.3 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETO01839.1 - 0.022 15.1 0.1 0.037 14.3 0.0 1.5 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO01839.1 - 0.098 12.7 0.0 0.15 12.1 0.0 1.3 1 1 0 1 1 1 0 Cation transport ATPase (P-type) WD40 PF00400.32 ETO01840.1 - 8e-82 267.0 24.9 2.5e-11 43.9 0.2 8.4 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01840.1 - 1.5e-30 105.4 1.3 0.00023 21.4 0.0 8.2 1 1 7 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01840.1 - 1.8e-17 63.7 3.9 0.00065 19.1 0.1 5.7 3 1 3 6 6 6 5 WD40-like domain Ge1_WD40 PF16529.5 ETO01840.1 - 2.7e-12 46.3 5.9 0.45 9.4 0.0 7.7 3 2 5 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO01840.1 - 1.8e-06 27.7 11.7 7.4 6.6 0.0 7.5 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO01840.1 - 3e-06 26.8 2.7 0.00035 20.1 0.3 1.8 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) PQQ_2 PF13360.6 ETO01840.1 - 3.7e-06 26.7 0.8 0.017 14.7 0.1 3.7 1 1 1 2 2 2 2 PQQ-like domain Gmad1 PF10647.9 ETO01840.1 - 6.7e-05 22.8 0.1 1.6 8.4 0.1 4.2 2 1 1 3 3 3 2 Lipoprotein LpqB beta-propeller domain GspH PF12019.8 ETO01840.1 - 0.0012 19.3 3.7 3.5 8.1 0.5 5.0 2 1 1 3 3 3 1 Type II transport protein GspH DUF5570 PF17731.1 ETO01840.1 - 0.0027 17.8 11.0 1.7 8.8 0.6 5.6 1 1 5 6 6 6 2 Family of unknown function (DUF5570) Rpn3_C PF08375.11 ETO01840.1 - 0.024 15.1 0.0 34 5.0 0.0 4.6 5 0 0 5 5 5 0 Proteasome regulatory subunit C-terminal DUF3475 PF11961.8 ETO01840.1 - 0.031 14.3 0.1 80 3.4 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) PQQ PF01011.21 ETO01840.1 - 0.035 14.0 0.0 1.2e+02 2.9 0.0 4.7 5 0 0 5 5 5 0 PQQ enzyme repeat DUF3292 PF11696.8 ETO01840.1 - 0.14 10.5 3.5 0.21 9.9 3.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Proteasome_A_N PF10584.9 ETO01840.1 - 1.4 8.7 18.4 24 4.7 0.0 7.0 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Peptidase_M1_N PF17900.1 ETO01841.1 - 0.00022 21.5 0.0 0.00024 21.3 0.0 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain RNA_bind PF08675.11 ETO01841.1 - 0.011 15.8 0.0 0.014 15.4 0.0 1.2 1 0 0 1 1 1 0 RNA binding domain WD40 PF00400.32 ETO01842.1 - 0.00082 20.1 7.4 0.00092 20.0 1.3 3.4 3 2 0 3 3 3 1 WD domain, G-beta repeat RE_HindVP PF09519.10 ETO01843.1 - 0.0032 16.5 0.1 0.0043 16.1 0.1 1.1 1 0 0 1 1 1 1 HindVP restriction endonuclease PAP_assoc PF03828.19 ETO01844.1 - 5.8e-09 36.0 3.2 7.9e-09 35.6 0.3 2.8 2 1 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETO01844.1 - 5.7e-05 23.3 0.0 0.00019 21.7 0.0 1.9 1 0 0 1 1 1 1 Nucleotidyltransferase domain SPX PF03105.19 ETO01844.1 - 0.0048 16.9 11.0 0.0048 16.9 11.0 1.6 2 1 0 2 2 2 1 SPX domain PAP_central PF04928.17 ETO01844.1 - 0.022 13.8 0.2 0.94 8.4 0.0 2.4 2 0 0 2 2 2 0 Poly(A) polymerase central domain zf-C3HC4_3 PF13920.6 ETO01845.1 - 1.1e-08 34.8 8.6 1.7e-08 34.2 8.6 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO01845.1 - 2.9e-06 27.2 5.3 8.4e-06 25.7 5.3 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO01845.1 - 4.5e-06 26.4 10.7 8.5e-06 25.5 10.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO01845.1 - 2.1e-05 24.3 9.6 4.1e-05 23.4 9.6 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ETO01845.1 - 3.4e-05 23.9 6.0 0.00011 22.2 6.0 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ETO01845.1 - 8.2e-05 22.5 11.0 0.00027 20.8 11.2 1.8 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO01845.1 - 0.00013 21.7 9.8 0.00032 20.5 9.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO01845.1 - 0.0017 18.6 11.4 0.005 17.2 11.5 1.7 1 1 0 1 1 1 1 Ring finger domain Fur_reg_FbpA PF13076.6 ETO01845.1 - 0.0043 16.7 1.1 0.016 14.9 0.7 2.1 2 0 0 2 2 2 1 Fur-regulated basic protein A DUF1192 PF06698.11 ETO01845.1 - 0.035 14.2 0.5 3.2 7.9 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) zf-rbx1 PF12678.7 ETO01845.1 - 0.12 12.6 6.4 0.34 11.2 6.4 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Zn_Tnp_IS91 PF14319.6 ETO01845.1 - 0.88 9.7 6.8 3.5 7.7 6.8 2.0 1 1 0 1 1 1 0 Transposase zinc-binding domain CPSase_L_D3 PF02787.19 ETO01845.1 - 1.3 9.4 13.1 0.63 10.4 1.1 2.7 3 1 0 3 3 3 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain zf-RING_4 PF14570.6 ETO01845.1 - 2.4 8.0 11.3 2.2 8.2 4.3 2.4 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Macoilin PF09726.9 ETO01845.1 - 5.3 5.5 25.5 7.3 5.0 25.5 1.1 1 0 0 1 1 1 0 Macoilin family TPR_12 PF13424.6 ETO01846.1 - 2.3e-68 226.5 20.0 9.7e-17 61.0 0.1 6.6 5 1 2 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01846.1 - 2e-51 169.8 75.9 1.4e-07 31.0 0.1 10.5 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01846.1 - 2.6e-47 157.5 24.0 6.8e-07 29.0 0.0 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01846.1 - 3.8e-41 135.9 54.7 2.3e-05 24.1 0.4 10.4 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01846.1 - 1.9e-35 118.3 17.8 0.00032 20.5 0.1 10.9 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01846.1 - 4.8e-27 91.9 61.6 3.7e-06 26.7 0.7 10.8 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01846.1 - 3.4e-18 64.6 30.7 0.0028 17.9 0.2 9.4 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01846.1 - 5.7e-16 58.9 0.4 0.17 12.6 0.0 7.2 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01846.1 - 3.7e-14 52.3 13.8 0.46 11.2 0.0 10.1 10 0 0 10 10 9 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01846.1 - 6.9e-14 51.4 0.0 26 6.0 0.0 9.3 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01846.1 - 9.9e-14 50.8 66.1 0.00093 18.8 2.2 12.2 8 2 3 11 11 10 5 TPR repeat TPR_19 PF14559.6 ETO01846.1 - 1.7e-07 31.6 10.3 0.1 13.1 0.1 6.1 6 0 0 6 6 5 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO01846.1 - 8.5e-06 25.6 39.1 0.00081 19.2 0.6 6.5 1 1 4 5 5 5 2 Uncharacterized protein conserved in bacteria (DUF2225) SMBP PF16785.5 ETO01846.1 - 4e-05 23.8 0.1 4 7.7 0.1 5.0 3 2 0 3 3 3 1 Small metal-binding protein ANAPC3 PF12895.7 ETO01846.1 - 4.1e-05 23.7 34.2 1.6 9.0 5.7 7.5 4 3 3 7 7 6 3 Anaphase-promoting complex, cyclosome, subunit 3 zf-TRAF PF02176.18 ETO01846.1 - 4.3e-05 24.1 1.5 4.3e-05 24.1 1.5 2.1 2 0 0 2 2 1 1 TRAF-type zinc finger TPR_5 PF12688.7 ETO01846.1 - 8.6e-05 22.8 0.0 9.6 6.5 0.0 4.2 3 2 1 4 4 3 0 Tetratrico peptide repeat SHNi-TPR PF10516.9 ETO01846.1 - 0.00011 21.6 6.7 10 5.7 0.0 7.3 7 0 0 7 7 7 0 SHNi-TPR RPN7 PF10602.9 ETO01846.1 - 0.0017 18.1 0.6 0.0017 18.1 0.6 6.0 4 4 3 8 8 6 1 26S proteasome subunit RPN7 PPR PF01535.20 ETO01846.1 - 0.0036 17.5 8.9 27 5.3 0.0 7.2 8 0 0 8 8 7 0 PPR repeat MIT PF04212.18 ETO01846.1 - 0.016 15.3 47.4 1.4 9.1 0.4 9.9 9 2 2 11 11 10 0 MIT (microtubule interacting and transport) domain zf-RING-like PF08746.11 ETO01846.1 - 0.14 12.5 0.9 2.4 8.5 0.3 3.0 2 1 0 2 2 2 0 RING-like domain DUF5113 PF17140.4 ETO01846.1 - 0.27 11.0 46.5 1.1 9.0 0.1 9.7 7 2 3 10 10 10 0 Domain of unknown function (DUF5113) Exonuc_VII_L PF02601.15 ETO01846.1 - 0.69 9.4 17.0 1.8 8.0 9.5 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit TPR_3 PF07720.12 ETO01846.1 - 1.2 9.2 42.7 0.7 9.9 0.1 7.1 7 0 0 7 7 6 0 Tetratricopeptide repeat HIP1_clath_bdg PF16515.5 ETO01846.1 - 2.1 9.0 18.8 5.7 7.6 17.2 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Jnk-SapK_ap_N PF09744.9 ETO01846.1 - 2.2 8.5 20.2 7.4 6.8 20.2 1.9 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Sel1 PF08238.12 ETO01846.1 - 5.6 7.8 17.3 56 4.6 0.0 7.2 9 0 0 9 9 7 0 Sel1 repeat Spc24 PF08286.11 ETO01846.1 - 8.6 6.7 21.1 1.1 9.6 4.2 3.8 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 TPR_12 PF13424.6 ETO01848.1 - 1.7e-107 351.8 11.8 3.4e-22 78.5 0.0 5.4 1 1 5 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01848.1 - 4.3e-78 255.3 0.6 1.1e-11 44.2 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01848.1 - 7.6e-59 191.5 9.0 1.6e-08 33.9 0.0 7.2 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01848.1 - 9.4e-55 180.3 39.1 1.1e-09 37.7 0.3 7.3 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01848.1 - 1.1e-44 146.9 42.1 3e-09 36.4 1.1 7.5 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01848.1 - 1.7e-43 143.2 23.2 3e-07 30.0 0.1 7.4 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01848.1 - 1.6e-28 99.0 0.0 0.0002 22.0 0.0 7.1 5 2 2 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01848.1 - 1.1e-26 91.2 20.2 0.0014 18.9 1.0 8.6 8 2 0 8 8 8 6 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO01848.1 - 3.6e-18 66.0 0.0 1.9e-07 30.8 0.0 3.0 1 1 2 3 3 3 3 MalT-like TPR region PPR PF01535.20 ETO01848.1 - 3.6e-16 58.2 20.1 0.11 12.8 0.1 7.3 7 0 0 7 7 7 6 PPR repeat TPR_14 PF13428.6 ETO01848.1 - 5.3e-16 57.9 0.0 0.19 12.6 0.0 6.8 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO01848.1 - 2.9e-14 52.7 1.3 0.39 11.5 0.0 7.2 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01848.1 - 1e-13 50.7 48.0 0.0013 18.4 4.5 10.6 7 5 6 13 13 12 8 TPR repeat DUF5113 PF17140.4 ETO01848.1 - 4.6e-13 49.3 19.3 0.048 13.5 0.1 6.9 5 1 2 7 7 7 4 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO01848.1 - 4.8e-12 46.2 0.9 0.033 14.7 0.0 5.1 2 2 4 6 6 6 3 Tetratricopeptide repeat SNAP PF14938.6 ETO01848.1 - 4.4e-11 42.7 13.8 4.4e-05 23.1 4.4 4.1 1 1 1 3 3 3 3 Soluble NSF attachment protein, SNAP TPR_3 PF07720.12 ETO01848.1 - 1.8e-08 34.2 19.6 0.46 10.5 0.2 6.7 7 0 0 7 7 6 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO01848.1 - 7.7e-07 28.5 1.4 0.95 9.0 0.0 5.9 6 0 0 6 6 6 1 SHNi-TPR OrfA PF17495.2 ETO01848.1 - 8.6e-07 29.1 0.0 30 4.9 0.0 5.9 1 1 5 6 6 6 0 Vpr-like OrfA RPN7 PF10602.9 ETO01848.1 - 1e-05 25.4 13.4 0.22 11.2 1.2 5.2 2 2 2 5 5 5 1 26S proteasome subunit RPN7 TPR_21 PF09976.9 ETO01848.1 - 2e-05 24.4 10.5 0.016 14.9 0.3 5.1 2 2 3 5 5 5 2 Tetratricopeptide repeat-like domain DUF627 PF04781.12 ETO01848.1 - 4.4e-05 23.5 7.0 2.9 7.9 0.0 5.6 6 1 1 7 7 7 1 Protein of unknown function (DUF627) MIT PF04212.18 ETO01848.1 - 6.5e-05 22.9 31.0 1.3 9.2 0.3 6.9 6 1 1 7 7 7 3 MIT (microtubule interacting and transport) domain HTH_Bact PF18768.1 ETO01848.1 - 8e-05 22.1 4.9 2.3 7.9 0.0 6.7 6 1 1 7 7 7 1 Helix-turn-helix bacterial domain UBA_6 PF18039.1 ETO01848.1 - 0.00084 19.2 0.0 22 5.1 0.0 4.6 5 0 0 5 5 4 0 UBA-like domain Sel1 PF08238.12 ETO01848.1 - 0.00089 19.9 14.7 12 6.7 0.0 7.3 7 2 0 7 7 6 0 Sel1 repeat ANAPC3 PF12895.7 ETO01848.1 - 0.00095 19.3 15.2 0.046 14.0 2.8 4.5 2 1 4 6 6 6 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO01848.1 - 0.0011 19.4 8.3 1.4 9.5 0.2 5.2 3 3 0 4 4 4 1 Domain of unknown function (DUF4810) Ten1_2 PF15490.6 ETO01848.1 - 0.0015 18.2 0.0 14 5.4 0.0 4.4 1 1 5 6 6 6 0 Telomere-capping, CST complex subunit BTAD PF03704.17 ETO01848.1 - 0.0069 16.8 0.0 8.2 6.9 0.0 2.9 3 0 0 3 3 3 0 Bacterial transcriptional activator domain TPR_9 PF13371.6 ETO01848.1 - 0.012 15.7 0.0 7.3 6.8 0.0 3.7 3 2 0 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 ETO01848.1 - 0.049 12.9 0.0 2.1 7.5 0.0 3.2 2 2 0 4 4 4 0 Tetratricopeptide repeat FATC PF02260.20 ETO01848.1 - 0.05 13.4 3.3 62 3.5 0.2 4.3 4 0 0 4 4 4 0 FATC domain NRDE-2 PF08424.10 ETO01848.1 - 0.057 12.5 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference Clathrin PF00637.20 ETO01848.1 - 0.07 13.0 16.9 1.3 8.9 1.0 6.0 4 2 1 6 6 6 0 Region in Clathrin and VPS Urocanase_N PF17391.2 ETO01848.1 - 0.11 12.2 1.0 2.3 7.9 0.0 3.3 2 2 1 3 3 3 0 Urocanase N-terminal domain HisG PF01634.18 ETO01848.1 - 0.19 11.7 0.5 17 5.3 0.0 3.5 3 1 1 4 4 4 0 ATP phosphoribosyltransferase Mob_Pre PF01076.19 ETO01848.1 - 0.19 11.5 9.2 16 5.2 0.3 3.8 2 1 3 5 5 5 0 Plasmid recombination enzyme Pep3_Vps18 PF05131.14 ETO01848.1 - 0.22 11.4 8.2 7 6.5 0.1 5.5 7 0 0 7 7 6 0 Pep3/Vps18/deep orange family Mad3_BUB1_I PF08311.12 ETO01848.1 - 0.8 9.7 13.8 30 4.6 0.0 6.2 7 1 1 8 8 7 0 Mad3/BUB1 homology region 1 ATP-synt_E_2 PF08112.11 ETO01848.1 - 2 8.7 17.8 5.6 7.3 0.2 5.9 6 0 0 6 6 6 0 ATP synthase epsilon subunit PPR_2 PF13041.6 ETO01848.1 - 3.5 7.9 15.9 19 5.5 0.1 6.3 7 0 0 7 7 7 0 PPR repeat family ER PF01133.17 ETO01848.1 - 5.6 7.1 7.5 1.6 8.8 0.3 3.4 4 0 0 4 4 4 0 Enhancer of rudimentary Geminin PF07412.12 ETO01849.1 - 0.00082 19.2 2.2 0.00082 19.2 2.2 2.2 2 0 0 2 2 2 1 Geminin Csm1_N PF18504.1 ETO01849.1 - 0.0014 18.9 11.6 0.043 14.2 4.2 2.1 2 0 0 2 2 2 2 Csm1 N-terminal domain DUF641 PF04859.12 ETO01849.1 - 0.012 16.0 10.3 0.2 12.0 1.0 2.1 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) HIP1_clath_bdg PF16515.5 ETO01849.1 - 0.063 13.9 9.9 0.19 12.3 0.4 2.1 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Bap31_Bap29_C PF18035.1 ETO01849.1 - 0.11 12.6 18.0 0.26 11.3 5.3 2.4 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain PKcGMP_CC PF16808.5 ETO01849.1 - 0.11 12.4 14.5 0.1 12.5 4.4 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DivIC PF04977.15 ETO01849.1 - 0.13 12.0 14.5 0.21 11.4 0.3 3.0 2 1 1 3 3 3 0 Septum formation initiator CC2-LZ PF16516.5 ETO01849.1 - 0.22 11.9 9.1 0.49 10.8 1.6 2.2 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF1640 PF07798.11 ETO01849.1 - 0.27 11.3 7.1 0.31 11.0 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Wtap PF17098.5 ETO01849.1 - 0.33 10.9 7.5 0.35 10.8 6.3 1.6 1 1 1 2 2 2 0 WTAP/Mum2p family DUF4200 PF13863.6 ETO01849.1 - 0.93 9.9 16.7 1.7 9.1 5.5 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) bZIP_1 PF00170.21 ETO01849.1 - 2 8.6 14.3 1.9 8.7 1.2 3.0 2 1 1 3 3 3 0 bZIP transcription factor TMF_DNA_bd PF12329.8 ETO01849.1 - 2.8 8.0 17.6 1.4 9.0 3.7 2.8 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.11 ETO01849.1 - 4.8 7.6 9.8 1.5 9.2 1.9 2.5 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.6 ETO01849.1 - 5.4 7.5 6.6 1.7e+02 2.7 6.5 2.2 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) YabA PF06156.13 ETO01849.1 - 9.7 6.9 11.6 16 6.2 0.8 2.5 2 1 0 2 2 2 0 Initiation control protein YabA zf-C3HC4_3 PF13920.6 ETO01850.1 - 2.6 8.0 9.1 1.8 8.5 5.0 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CNH PF00780.22 ETO01851.1 - 0.0026 17.4 0.9 0.5 9.9 0.1 2.8 2 1 0 2 2 2 2 CNH domain BBS2_N PF14781.6 ETO01851.1 - 0.046 13.6 0.0 1.1 9.2 0.0 2.6 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal Hira PF07569.11 ETO01851.1 - 0.046 13.4 0.0 1.1 9.0 0.0 2.4 2 1 0 2 2 2 0 TUP1-like enhancer of split PQQ_3 PF13570.6 ETO01851.1 - 0.08 13.5 2.2 4.3 8.0 0.1 3.8 4 0 0 4 4 4 0 PQQ-like domain DNA_pol_E_B PF04042.16 ETO01852.1 - 0.14 11.5 0.0 0.17 11.2 0.0 1.1 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B PhoQ_Sensor PF08918.10 ETO01853.1 - 0.032 14.1 0.7 0.044 13.6 0.7 1.2 1 0 0 1 1 1 0 PhoQ Sensor ERAP1_C PF11838.8 ETO01854.1 - 6.5e-21 75.2 0.0 7.8e-21 74.9 0.0 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Xan_ur_permease PF00860.20 ETO01855.1 - 9e-23 80.6 42.5 1.2e-22 80.2 42.5 1.1 1 0 0 1 1 1 1 Permease family FAM176 PF14851.6 ETO01855.1 - 0.038 13.7 2.9 4 7.1 2.2 2.7 2 0 0 2 2 2 0 FAM176 family DUF848 PF05852.11 ETO01856.1 - 0.011 15.9 0.2 2.5 8.2 0.1 2.2 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Kelch_2 PF07646.15 ETO01856.1 - 0.021 14.8 0.0 0.46 10.5 0.0 3.1 4 0 0 4 4 4 0 Kelch motif PigN PF04987.14 ETO01856.1 - 0.071 12.0 0.2 0.1 11.5 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) G_path_suppress PF15991.5 ETO01856.1 - 0.072 13.2 9.2 3.1 7.9 6.3 2.1 2 0 0 2 2 2 0 G-protein pathway suppressor WD40 PF00400.32 ETO01857.1 - 3.7e-28 97.2 0.2 4.7e-08 33.6 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01857.1 - 1.6e-08 34.8 0.3 0.27 11.6 0.0 4.5 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO01857.1 - 2.6e-06 26.6 0.0 0.012 14.5 0.0 3.2 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO01857.1 - 9.2e-06 25.5 0.1 0.69 9.9 0.0 4.2 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO01857.1 - 0.00075 18.1 0.0 0.0078 14.8 0.0 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain Ricin_B_lectin PF00652.22 ETO01857.1 - 0.026 14.8 0.0 3.6 7.9 0.0 2.3 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain Nup160 PF11715.8 ETO01857.1 - 0.054 12.1 0.1 4.9 5.7 0.0 2.3 2 1 0 2 2 2 0 Nucleoporin Nup120/160 MRJP PF03022.16 ETO01857.1 - 0.06 12.7 0.1 1.6 8.0 0.0 2.6 1 1 1 3 3 3 0 Major royal jelly protein DUF2431 PF10354.9 ETO01857.1 - 0.095 13.0 0.1 7.9 6.7 0.0 2.5 3 1 0 3 3 3 0 Domain of unknown function (DUF2431) Proteasome_A_N PF10584.9 ETO01857.1 - 0.12 12.1 1.5 17 5.2 0.0 4.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO01857.1 - 0.18 11.9 0.0 2.9 8.0 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5570) Nop53 PF07767.11 ETO01858.1 - 0.00096 18.6 45.6 0.0011 18.4 45.6 1.0 1 0 0 1 1 1 1 Nop53 (60S ribosomal biogenesis) DUF2457 PF10446.9 ETO01858.1 - 1.1 8.3 44.1 1.4 8.0 44.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Apt1 PF10351.9 ETO01858.1 - 2.1 7.1 36.1 3.2 6.5 36.1 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF572 PF04502.13 ETO01858.1 - 6.6 6.3 40.0 7.6 6.0 40.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) WD40 PF00400.32 ETO01860.1 - 9.7e-17 61.1 6.0 3.5e-05 24.5 0.0 4.6 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01860.1 - 4.7e-05 23.6 0.2 0.56 10.5 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO01860.1 - 0.00017 20.4 0.4 0.47 9.0 0.1 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO01860.1 - 0.00051 19.5 2.5 0.36 10.1 0.2 2.3 1 1 1 2 2 2 2 WD40-like domain TolB_N PF04052.13 ETO01860.1 - 0.11 12.7 0.0 2.7 8.2 0.0 2.5 2 1 1 3 3 3 0 TolB amino-terminal domain AAA_5 PF07728.14 ETO01861.1 - 0.0021 18.1 0.0 0.0038 17.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 ETO01861.1 - 0.029 14.3 0.0 0.044 13.7 0.0 1.3 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 ETO01861.1 - 0.092 13.0 0.1 0.23 11.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETO01861.1 - 0.13 11.8 0.0 0.2 11.1 0.0 1.4 1 1 0 1 1 1 0 P-loop containing dynein motor region Kinase-PPPase PF03618.14 ETO01861.1 - 0.16 11.7 0.0 0.3 10.8 0.0 1.4 1 0 0 1 1 1 0 Kinase/pyrophosphorylase SAM_Ste50p PF09235.10 ETO01865.1 - 0.01 16.1 0.1 0.014 15.6 0.1 1.4 1 1 0 1 1 1 0 Ste50p, sterile alpha motif Terminase_4 PF05119.12 ETO01865.1 - 0.047 14.1 0.0 0.078 13.4 0.0 1.4 1 1 0 1 1 1 0 Phage terminase, small subunit Kelch_1 PF01344.25 ETO01866.1 - 0.0011 18.5 0.1 0.0017 17.9 0.1 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_5 PF13854.6 ETO01866.1 - 0.0019 18.1 0.4 0.0035 17.3 0.4 1.3 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 ETO01866.1 - 0.0035 17.6 0.0 0.019 15.3 0.1 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO01866.1 - 0.11 12.5 0.2 0.47 10.5 0.2 2.0 2 0 0 2 2 2 0 Kelch motif Tubulin PF00091.25 ETO01869.1 - 1.1e-62 211.8 0.1 1.3e-62 211.5 0.1 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO01869.1 - 0.00041 19.6 0.0 0.00064 19.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Misat_Tub_SegII PF10644.9 ETO01869.1 - 0.037 14.3 0.0 0.056 13.7 0.0 1.3 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain RACo_linker PF17650.1 ETO01873.1 - 0.0049 16.7 0.0 0.01 15.7 0.0 1.5 1 0 0 1 1 1 1 RACo linker region RED_C PF07807.11 ETO01873.1 - 0.0093 16.4 0.4 0.032 14.7 0.2 2.0 2 0 0 2 2 2 1 RED-like protein C-terminal region FAM163 PF15069.6 ETO01873.1 - 0.013 15.9 0.1 0.03 14.8 0.1 1.5 1 0 0 1 1 1 0 FAM163 family DUF3585 PF12130.8 ETO01873.1 - 0.05 13.7 4.3 0.35 11.0 0.3 2.4 2 0 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain MTTB PF06253.11 ETO01873.1 - 0.27 9.2 0.6 0.38 8.7 0.6 1.1 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Ribosomal_L27e PF01777.18 ETO01873.1 - 0.68 10.3 3.2 2.9 8.3 0.2 3.1 2 1 1 3 3 3 0 Ribosomal L27e protein family AAA PF00004.29 ETO01874.1 - 4.6e-10 40.0 0.0 0.00081 19.8 0.0 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO01874.1 - 2.1e-08 33.9 0.0 6e-05 22.6 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO01874.1 - 8e-08 32.4 0.0 0.00043 20.3 0.0 3.7 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO01874.1 - 3.4e-07 30.6 0.0 0.045 14.0 0.0 2.9 2 0 0 2 2 2 2 AAA domain AAA_16 PF13191.6 ETO01874.1 - 5e-05 23.8 0.1 0.0049 17.3 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO01874.1 - 7.9e-05 22.6 0.0 0.00053 19.9 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase AAA_14 PF13173.6 ETO01874.1 - 0.00022 21.3 0.3 0.024 14.7 0.0 3.2 3 1 0 3 3 3 1 AAA domain ABC_tran PF00005.27 ETO01874.1 - 0.00034 21.1 0.0 0.0019 18.7 0.0 2.2 2 0 0 2 2 2 1 ABC transporter ATPase_2 PF01637.18 ETO01874.1 - 0.0008 19.4 1.7 0.34 10.8 0.0 3.2 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 ETO01874.1 - 0.00082 19.2 0.1 0.024 14.4 0.0 2.3 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_8 PF12780.7 ETO01874.1 - 0.0016 17.8 0.1 0.01 15.2 0.0 2.5 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 DUF815 PF05673.13 ETO01874.1 - 0.0035 16.6 0.0 0.012 14.8 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF815) MCM PF00493.23 ETO01874.1 - 0.0041 16.3 0.7 0.36 9.9 0.0 2.9 3 0 0 3 3 3 1 MCM P-loop domain PduV-EutP PF10662.9 ETO01874.1 - 0.0053 16.5 0.1 0.043 13.6 0.0 2.2 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_2 PF07724.14 ETO01874.1 - 0.008 16.3 0.0 0.22 11.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ETO01874.1 - 0.0099 15.6 0.1 1.3 8.7 0.0 3.4 4 0 0 4 4 3 1 IstB-like ATP binding protein Rad17 PF03215.15 ETO01874.1 - 0.013 15.4 0.2 0.32 10.9 0.0 3.0 3 0 0 3 3 2 0 Rad17 P-loop domain AAA_24 PF13479.6 ETO01874.1 - 0.015 15.0 0.2 0.046 13.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 ETO01874.1 - 0.043 13.2 0.4 5.4 6.3 0.0 3.2 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ETO01874.1 - 0.048 13.7 0.1 0.23 11.5 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETO01874.1 - 0.07 13.5 0.2 2.4 8.6 0.0 3.2 4 0 0 4 4 2 0 RNA helicase Sigma54_activat PF00158.26 ETO01874.1 - 0.092 12.4 0.1 2 8.1 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.12 ETO01874.1 - 0.1 12.5 0.5 0.72 9.8 0.1 2.6 2 1 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 ETO01874.1 - 0.22 11.2 0.0 21 4.7 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETO01874.1 - 0.31 11.4 4.4 3.4 8.0 0.1 3.6 2 2 1 3 3 3 0 AAA domain AAA_23 PF13476.6 ETO01874.1 - 8.5 6.8 8.2 68 3.9 8.2 2.5 1 1 0 1 1 1 0 AAA domain NST1 PF13945.6 ETO01875.1 - 8.8 6.4 22.2 9.7 6.2 22.2 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator Alpha-amylase PF00128.24 ETO01876.1 - 0.026 14.1 0.2 0.03 13.9 0.2 1.0 1 0 0 1 1 1 0 Alpha amylase, catalytic domain Telomerase_RBD PF12009.8 ETO01876.1 - 0.12 12.5 5.1 0.14 12.2 5.1 1.1 1 0 0 1 1 1 0 Telomerase ribonucleoprotein complex - RNA binding domain WD40 PF00400.32 ETO01877.1 - 1.6e-16 60.3 10.6 1.2e-07 32.2 0.9 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO01877.1 - 4e-06 25.8 1.6 0.0026 16.5 0.2 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01877.1 - 2.3e-05 24.6 0.2 0.0055 17.0 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01877.1 - 0.0026 17.1 2.9 0.0033 16.8 2.9 1.2 1 0 0 1 1 1 1 WD40-like domain W_rich_C PF07483.11 ETO01877.1 - 0.25 11.5 2.0 0.59 10.3 0.2 2.2 1 1 1 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain DUF4221 PF13970.6 ETO01877.1 - 0.27 10.7 7.0 0.5 9.9 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) UN_NPL4 PF11543.8 ETO01879.1 - 0.12 12.8 0.7 0.31 11.6 0.1 2.0 2 1 1 3 3 3 0 Nuclear pore localisation protein NPL4 Kelch_1 PF01344.25 ETO01880.1 - 9.4e-06 25.1 1.9 0.0013 18.3 0.3 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO01880.1 - 0.00022 21.2 0.6 0.018 15.1 0.3 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01880.1 - 0.00025 21.0 1.8 0.0022 17.9 0.4 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO01880.1 - 0.00027 21.2 0.9 0.0057 16.9 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO01880.1 - 0.014 15.6 2.6 2.9 8.3 0.1 3.3 4 0 0 4 4 3 0 Kelch motif DUF4820 PF16091.5 ETO01880.1 - 0.046 13.1 3.6 0.072 12.5 3.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Myc_N PF01056.18 ETO01880.1 - 0.22 11.4 6.3 0.33 10.8 6.3 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PBP_sp32 PF07222.12 ETO01880.1 - 0.45 9.9 6.8 0.76 9.2 6.8 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF1840 PF08895.11 ETO01880.1 - 0.54 10.6 4.9 1.2 9.5 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) FAM176 PF14851.6 ETO01880.1 - 1 9.0 9.5 1.9 8.2 9.5 1.4 1 0 0 1 1 1 0 FAM176 family Kelch_2 PF07646.15 ETO01880.1 - 1.1 9.4 3.8 20 5.4 0.5 3.2 3 0 0 3 3 3 0 Kelch motif UPF0767 PF15990.5 ETO01880.1 - 3.2 7.9 4.9 2.3 8.4 2.9 1.8 2 0 0 2 2 2 0 UPF0767 family Caps_assemb_Wzi PF14052.6 ETO01881.1 - 0.025 13.6 0.0 0.025 13.6 0.0 1.6 2 0 0 2 2 2 0 Capsule assembly protein Wzi FTCD_C PF04961.12 ETO01881.1 - 0.044 13.6 0.1 0.092 12.5 0.1 1.5 1 0 0 1 1 1 0 Formiminotransferase-cyclodeaminase CENP-R PF06729.12 ETO01881.1 - 2.4 8.1 7.5 6.2 6.8 0.3 2.4 2 0 0 2 2 2 0 Kinetochore component, CENP-R GlcNAc PF11397.8 ETO01882.1 - 8.7e-11 41.9 0.0 1.4e-10 41.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) HPS3_Mid PF14762.6 ETO01882.1 - 0.0012 17.7 0.0 0.0035 16.2 0.0 1.6 2 0 0 2 2 2 1 Hermansky-Pudlak syndrome 3, middle region zf-HC5HC2H_2 PF13832.6 ETO01882.1 - 0.0033 17.6 1.9 0.66 10.2 1.1 2.3 1 1 1 2 2 2 2 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO01882.1 - 0.28 11.5 3.4 2.5 8.4 0.2 2.4 2 0 0 2 2 2 0 PHD-like zinc-binding domain EF-G-binding_N PF07299.11 ETO01883.1 - 0.025 15.1 0.3 0.056 14.0 0.0 1.8 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal STI1 PF17830.1 ETO01883.1 - 0.025 14.5 0.1 0.061 13.3 0.1 1.6 1 0 0 1 1 1 0 STI1 domain TPR_12 PF13424.6 ETO01884.1 - 4.4e-62 206.3 3.1 4.1e-22 78.2 0.1 3.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO01884.1 - 1.9e-37 126.1 0.0 3.8e-12 45.7 0.0 4.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO01884.1 - 5.1e-27 91.9 1.1 6.6e-09 35.2 0.0 3.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO01884.1 - 6.2e-24 82.8 14.7 1.2e-08 34.4 0.1 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO01884.1 - 1e-18 65.9 13.6 8.1e-06 25.7 0.2 3.9 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO01884.1 - 2.2e-15 55.4 5.0 0.00029 20.7 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO01884.1 - 4.3e-13 48.6 2.2 0.0032 17.8 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO01884.1 - 7e-08 33.0 0.0 0.094 13.4 0.0 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO01884.1 - 5.5e-06 26.3 0.8 0.35 10.7 0.1 3.1 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) MIT PF04212.18 ETO01884.1 - 7.7e-06 25.9 3.6 0.021 14.9 0.0 3.5 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO01884.1 - 5.4e-05 23.6 0.4 12 6.8 0.0 4.3 5 1 0 5 5 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO01884.1 - 0.0001 22.8 0.0 2.7 9.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO01884.1 - 0.0002 21.5 0.6 0.77 10.0 0.1 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ETO01884.1 - 0.00038 20.5 1.4 0.19 12.0 0.0 3.2 3 0 0 3 3 3 1 PPR repeat TPR_19 PF14559.6 ETO01884.1 - 0.0011 19.4 0.0 0.18 12.3 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO01884.1 - 0.0014 18.5 6.4 3.6 7.7 0.1 4.0 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO01884.1 - 0.0018 17.9 16.3 0.75 9.5 0.2 6.0 5 3 3 8 8 8 2 TPR repeat KH_4 PF13083.6 ETO01884.1 - 0.0045 16.8 0.0 0.059 13.3 0.0 2.2 1 1 1 2 2 2 1 KH domain HTH_Bact PF18768.1 ETO01884.1 - 0.0065 16.0 0.2 21 4.8 0.0 3.6 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO01884.1 - 0.012 15.6 0.3 18 5.4 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF627) Fis1_TPR_C PF14853.6 ETO01884.1 - 0.022 14.8 0.8 15 5.8 0.1 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_MalT PF17874.1 ETO01884.1 - 0.028 13.8 0.0 0.034 13.5 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region SNAP PF14938.6 ETO01884.1 - 0.038 13.4 0.0 6.2 6.2 0.0 1.9 1 1 0 2 2 2 0 Soluble NSF attachment protein, SNAP DUF4810 PF16068.5 ETO01884.1 - 0.083 13.4 0.2 6.8 7.3 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4810) Cu_bind_like PF02298.17 ETO01885.1 - 0.13 12.3 1.5 23 5.1 0.0 3.0 3 1 0 3 3 3 0 Plastocyanin-like domain Thioredoxin PF00085.20 ETO01887.1 - 0.16 12.0 1.0 0.25 11.4 0.2 1.7 2 0 0 2 2 2 0 Thioredoxin PrpR_N PF06506.11 ETO01887.1 - 0.17 11.5 0.0 2.7 7.6 0.0 2.2 2 0 0 2 2 2 0 Propionate catabolism activator Pentapeptide PF00805.22 ETO01888.1 - 0.00068 19.2 5.5 0.0048 16.5 0.3 2.7 2 1 1 3 3 3 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO01888.1 - 0.0047 17.1 1.7 0.016 15.4 1.2 1.7 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO01888.1 - 0.14 12.4 2.1 0.51 10.5 2.1 1.9 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) WD40 PF00400.32 ETO01889.1 - 3.5e-55 182.7 15.5 2.7e-09 37.5 0.1 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01889.1 - 1.1e-18 67.3 0.4 1.5e-05 25.2 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO01889.1 - 1.5e-15 57.0 0.4 0.016 14.2 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO01889.1 - 0.00013 20.8 4.2 0.54 8.8 0.0 4.6 3 1 2 5 5 5 2 Nucleoporin Nup120/160 HARP PF07443.13 ETO01889.1 - 0.0018 17.8 0.3 4 7.2 0.0 3.4 3 0 0 3 3 3 2 HepA-related protein (HARP) WD40_like PF17005.5 ETO01889.1 - 0.002 17.5 0.2 0.98 8.7 0.0 3.0 1 1 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO01889.1 - 0.024 13.2 0.5 3.4 6.1 0.1 2.8 2 1 0 3 3 3 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO01889.1 - 0.14 11.0 0.0 0.75 8.6 0.0 2.0 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO01889.1 - 3.9 7.5 6.5 2 8.5 0.2 3.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Choline_transpo PF04515.12 ETO01890.1 - 4.1e-09 36.1 26.6 3.4e-07 29.8 26.6 2.6 1 1 0 1 1 1 1 Plasma-membrane choline transporter TMEM208_SND2 PF05620.11 ETO01890.1 - 1.6 8.5 12.7 0.1 12.4 3.8 2.2 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Sec23_helical PF04815.15 ETO01892.1 - 0.0057 16.5 0.4 0.11 12.4 0.1 2.7 1 1 1 2 2 2 1 Sec23/Sec24 helical domain DUF5345 PF17280.2 ETO01892.1 - 0.069 13.1 0.5 0.27 11.2 0.3 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5345) Secretin_N_2 PF07655.13 ETO01892.1 - 3.9 8.1 8.8 1.6 9.4 4.6 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain WD40 PF00400.32 ETO01893.1 - 0.019 15.8 0.8 2.6 9.1 0.2 2.6 2 0 0 2 2 2 0 WD domain, G-beta repeat HAP1_N PF04849.13 ETO01894.1 - 0.01 15.1 6.7 0.013 14.8 6.7 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Cep57_MT_bd PF06657.13 ETO01894.1 - 0.044 14.2 1.4 0.044 14.2 1.4 2.0 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Flu_NS2 PF00601.19 ETO01895.1 - 0.013 15.8 4.4 3.7 7.9 0.1 3.5 3 1 0 3 3 3 0 Influenza non-structural protein (NS2) zf-CCHC PF00098.23 ETO01895.1 - 0.023 14.8 7.2 0.069 13.2 7.2 1.9 1 0 0 1 1 1 0 Zinc knuckle DUF3262 PF11660.8 ETO01897.1 - 0.0043 17.4 0.3 0.0066 16.8 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3262) DUF4366 PF14283.6 ETO01897.1 - 0.027 14.5 0.0 0.041 13.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Tad PF13400.6 ETO01897.1 - 0.042 14.2 0.4 0.06 13.7 0.4 1.2 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like SIT PF15330.6 ETO01897.1 - 0.058 13.8 0.3 0.1 13.0 0.0 1.6 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF5305 PF17231.2 ETO01897.1 - 0.084 12.3 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5305) HTH_Tnp_Tc3_2 PF01498.18 ETO01898.1 - 7.8e-12 45.3 0.5 1.3e-11 44.5 0.5 1.4 1 1 0 1 1 1 1 Transposase HTH_29 PF13551.6 ETO01898.1 - 0.0073 16.3 0.3 0.078 13.0 0.0 2.5 3 0 0 3 3 3 1 Winged helix-turn helix HTH_Tnp_1 PF01527.20 ETO01898.1 - 0.036 14.4 0.0 0.056 13.8 0.0 1.4 1 0 0 1 1 1 0 Transposase HTH_23 PF13384.6 ETO01898.1 - 0.076 12.8 0.1 0.78 9.6 0.0 2.5 3 0 0 3 3 3 0 Homeodomain-like domain Exo_endo_phos_2 PF14529.6 ETO01899.1 - 1e-06 28.5 2.8 2.2e-06 27.5 0.1 2.6 2 2 0 2 2 2 1 Endonuclease-reverse transcriptase PI_PP_I PF18363.1 ETO01899.1 - 0.19 11.9 1.8 0.69 10.1 0.4 2.3 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain ALMT PF11744.8 ETO01899.1 - 1.2 7.9 10.6 1.7 7.4 10.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Choline_sulf_C PF12411.8 ETO01900.1 - 0.087 12.7 0.2 2.3 8.1 0.0 2.4 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal Ank_4 PF13637.6 ETO01903.1 - 6.9e-07 29.7 0.1 3.7e-05 24.2 0.1 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO01903.1 - 7.9e-07 29.6 0.2 0.0046 17.5 0.0 2.3 2 1 2 4 4 4 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO01903.1 - 4.4e-05 23.6 0.1 0.0042 17.5 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO01903.1 - 0.0023 18.2 0.0 0.01 16.1 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO01903.1 - 0.011 16.2 0.0 0.029 14.8 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeat G-gamma PF00631.22 ETO01903.1 - 0.029 14.4 0.0 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 GGL domain WD40 PF00400.32 ETO01905.1 - 1.6e-47 158.5 13.0 8.5e-12 45.4 0.1 5.0 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01905.1 - 6.7e-21 74.4 0.2 1.4e-05 25.3 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01905.1 - 7.5e-11 41.9 0.3 0.0088 15.4 0.0 3.6 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO01905.1 - 5.6e-07 28.6 0.3 0.32 9.6 0.0 3.9 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO01905.1 - 1e-06 28.5 5.2 6.6 6.8 0.0 5.4 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO01905.1 - 1.4e-06 27.5 0.0 0.16 10.9 0.0 4.0 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_2 PF13360.6 ETO01905.1 - 1.7e-06 27.8 0.1 0.0029 17.2 0.1 2.4 1 1 1 2 2 2 2 PQQ-like domain BBS2_Mid PF14783.6 ETO01905.1 - 3.8e-05 23.7 0.4 2.1 8.4 0.1 4.0 1 1 2 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Frtz PF11768.8 ETO01905.1 - 4.4e-05 22.0 0.0 0.028 12.7 0.0 3.0 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETO01905.1 - 0.00023 21.3 6.8 3.2 7.9 0.1 4.0 1 1 3 4 4 4 1 Family of unknown function (DUF5570) PQQ PF01011.21 ETO01905.1 - 0.00044 20.1 0.0 4.8 7.3 0.0 4.1 4 0 0 4 4 4 1 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETO01905.1 - 0.0017 16.9 0.6 0.1 11.1 0.1 2.7 1 1 2 3 3 3 1 Cytochrome D1 heme domain GspH PF12019.8 ETO01905.1 - 0.0044 17.4 0.8 0.77 10.2 0.8 3.4 1 1 0 1 1 1 1 Type II transport protein GspH Str_synth PF03088.16 ETO01905.1 - 0.019 15.1 0.1 1.5 9.0 0.0 3.2 1 1 3 4 4 4 0 Strictosidine synthase RE_XamI PF09572.10 ETO01905.1 - 0.03 14.0 0.0 14 5.2 0.0 3.2 1 1 3 4 4 4 0 XamI restriction endonuclease Read-through PF16814.5 ETO01905.1 - 0.038 13.8 1.4 3.2 7.5 0.1 3.1 1 1 3 4 4 4 0 Read-through domain BLUF PF04940.12 ETO01905.1 - 0.042 14.0 0.0 15 5.8 0.0 3.1 3 0 0 3 3 3 0 Sensors of blue-light using FAD Rpn3_C PF08375.11 ETO01905.1 - 0.064 13.7 0.0 1 9.9 0.0 2.6 2 2 1 3 3 3 0 Proteasome regulatory subunit C-terminal TolB_N PF04052.13 ETO01905.1 - 0.079 13.1 0.0 58 3.9 0.0 3.7 4 0 0 4 4 4 0 TolB amino-terminal domain PH_TFIIH PF08567.11 ETO01905.1 - 0.37 11.1 1.9 1.5e+02 2.7 0.0 3.7 4 0 0 4 4 4 0 TFIIH p62 subunit, N-terminal domain CSN4_RPN5_eIF3a PF18420.1 ETO01905.1 - 0.59 10.3 3.9 55 4.1 0.0 3.7 4 0 0 4 4 4 0 CSN4/RPN5/eIF3a helix turn helix domain Proteasome_A_N PF10584.9 ETO01905.1 - 1.1 8.9 15.4 26 4.6 0.0 5.4 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Phospholip_B PF04916.13 ETO01907.1 - 5.2e-89 299.2 1.3 6.2e-89 299.0 1.3 1.1 1 0 0 1 1 1 1 Phospholipase B NB-ARC PF00931.22 ETO01912.1 - 0.00034 19.9 0.8 0.61 9.2 1.1 2.2 2 0 0 2 2 2 2 NB-ARC domain GTP1_OBG PF01018.22 ETO01912.1 - 0.0021 17.7 0.1 0.0033 17.0 0.1 1.2 1 0 0 1 1 1 1 GTP1/OBG NACHT PF05729.12 ETO01912.1 - 0.0034 17.3 0.0 0.018 15.0 0.0 1.9 2 0 0 2 2 2 1 NACHT domain THDPS_N PF14790.6 ETO01912.1 - 0.19 11.6 4.4 0.11 12.4 1.4 1.9 1 1 1 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal YodL PF14191.6 ETO01912.1 - 0.2 12.5 6.2 1.9 9.4 0.4 2.3 2 0 0 2 2 2 0 YodL-like zf-RING_2 PF13639.6 ETO01913.1 - 3.7e-05 24.0 5.3 8.3e-05 22.8 5.3 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETO01913.1 - 0.0014 18.9 3.6 0.0035 17.6 3.6 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO01913.1 - 0.0018 18.1 4.3 0.0041 17.0 4.3 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO01913.1 - 0.0021 18.2 0.9 0.0021 18.2 0.9 1.9 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-ANAPC11 PF12861.7 ETO01913.1 - 0.0047 16.9 0.9 0.01 15.9 0.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ETO01913.1 - 0.013 15.5 4.9 0.038 14.0 4.9 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ETO01913.1 - 0.12 12.3 3.4 0.29 11.0 3.4 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO01913.1 - 0.22 11.6 4.1 0.5 10.4 4.1 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Prok-RING_4 PF14447.6 ETO01913.1 - 0.22 11.4 5.4 0.5 10.3 5.4 1.6 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-RING_11 PF17123.5 ETO01913.1 - 0.25 11.1 5.5 0.98 9.2 5.5 2.0 1 1 0 1 1 1 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO01913.1 - 0.42 10.5 5.8 1.3 9.0 5.8 1.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3H2C3 PF17122.5 ETO01913.1 - 0.44 10.6 5.1 2.2 8.4 5.1 2.1 1 1 0 1 1 1 0 Zinc-finger zf-RING_2 PF13639.6 ETO01914.1 - 8.6e-09 35.6 10.0 8.6e-09 35.6 10.0 1.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO01914.1 - 1.4e-06 28.0 5.1 1.4e-06 28.0 5.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO01914.1 - 4.6e-06 26.4 6.8 4.6e-06 26.4 6.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO01914.1 - 7e-06 25.7 7.4 7e-06 25.7 7.4 2.3 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO01914.1 - 5.1e-05 23.2 5.0 5.1e-05 23.2 5.0 2.9 3 0 0 3 3 3 1 RING-type zinc-finger PHD PF00628.29 ETO01914.1 - 0.0001 22.1 5.9 0.0001 22.1 5.9 2.4 2 0 0 2 2 2 1 PHD-finger zf-RING_5 PF14634.6 ETO01914.1 - 0.00089 19.2 8.6 0.014 15.4 7.4 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETO01914.1 - 0.0015 18.8 10.3 0.0015 18.8 10.3 2.4 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ETO01914.1 - 0.014 15.6 5.8 0.014 15.6 5.8 2.4 1 1 1 2 2 1 0 zinc finger of C3HC4-type, RING Zn-ribbon_8 PF09723.10 ETO01914.1 - 0.05 13.7 0.7 0.05 13.7 0.7 2.5 3 0 0 3 3 2 0 Zinc ribbon domain zf-MIZ PF02891.20 ETO01914.1 - 0.62 9.9 7.4 2.6 7.8 7.5 2.0 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger PHD_4 PF16866.5 ETO01914.1 - 0.79 9.9 11.6 2.4 8.3 8.3 3.1 2 1 0 2 2 2 0 PHD-finger zf-ANAPC11 PF12861.7 ETO01914.1 - 1.3 9.1 13.8 0.081 13.0 7.5 2.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETO01914.1 - 3.3 7.4 14.4 9.5 5.9 14.4 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H PF13771.6 ETO01914.1 - 3.6 7.9 13.5 0.39 11.0 5.9 2.6 2 1 1 3 3 3 0 PHD-like zinc-binding domain zf-Di19 PF05605.12 ETO01914.1 - 3.8 7.9 9.8 0.53 10.6 2.9 2.7 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding SecA_DEAD PF07517.14 ETO01919.1 - 9.1e-09 35.0 0.0 4.5e-08 32.7 0.0 2.1 3 0 0 3 3 3 1 SecA DEAD-like domain Trp_dioxygenase PF03301.13 ETO01919.1 - 0.012 15.0 0.5 0.029 13.7 0.1 1.8 2 0 0 2 2 2 0 Tryptophan 2,3-dioxygenase TetR_C_37 PF18665.1 ETO01919.1 - 1.1 9.9 6.6 13 6.4 0.3 3.5 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain LssY_C PF14067.6 ETO01920.1 - 0.094 12.3 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 LssY C-terminus YajC PF02699.15 ETO01921.1 - 1.1 9.2 3.7 0.8 9.6 0.2 2.2 2 1 0 2 2 2 0 Preprotein translocase subunit WD40 PF00400.32 ETO01922.1 - 7.1e-05 23.5 1.9 0.00014 22.6 1.9 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat WD40 PF00400.32 ETO01924.1 - 5.4e-09 36.5 3.2 8.7e-08 32.7 0.6 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO01924.1 - 0.00092 19.5 0.0 0.0015 18.8 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 ETO01924.1 - 0.013 13.7 0.2 0.014 13.6 0.2 1.1 1 0 0 1 1 1 0 CRT10 Nup160 PF11715.8 ETO01924.1 - 0.051 12.2 0.0 0.062 11.9 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Erf4 PF10256.9 ETO01925.1 - 0.019 15.1 0.3 0.033 14.3 0.3 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family Kelch_5 PF13854.6 ETO01926.1 - 0.03 14.3 0.1 0.32 11.0 0.0 2.2 2 0 0 2 2 2 0 Kelch motif ENTH PF01417.20 ETO01928.1 - 0.06 13.4 0.9 0.11 12.5 0.1 1.8 2 1 0 2 2 2 0 ENTH domain Terminase_6C PF17289.2 ETO01928.1 - 0.096 12.8 0.3 0.17 12.0 0.3 1.3 1 1 0 1 1 1 0 Terminase RNaseH-like domain AAA_31 PF13614.6 ETO01929.1 - 8.5e-34 117.0 0.8 8.5e-34 117.0 0.8 2.2 2 1 1 3 3 3 1 AAA domain CBP_BcsQ PF06564.12 ETO01929.1 - 2.8e-13 49.9 0.0 5.1e-13 49.0 0.0 1.4 1 0 0 1 1 1 1 Cellulose biosynthesis protein BcsQ CbiA PF01656.23 ETO01929.1 - 8.2e-13 48.5 0.5 2e-12 47.3 0.0 1.9 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 ETO01929.1 - 6.4e-05 22.4 3.1 0.00023 20.5 0.1 2.6 2 1 0 2 2 2 1 ATPase MipZ ArsA_ATPase PF02374.15 ETO01929.1 - 0.00011 21.5 2.7 0.00013 21.3 0.0 2.4 3 0 0 3 3 3 1 Anion-transporting ATPase ParA PF10609.9 ETO01929.1 - 0.00015 21.3 0.7 0.00049 19.6 0.7 1.7 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase Phage_T7_Capsid PF05396.11 ETO01929.1 - 0.067 13.6 0.1 0.18 12.2 0.1 1.7 1 0 0 1 1 1 0 Phage T7 capsid assembly protein RSD-2 PF07547.13 ETO01929.1 - 7.9 7.1 8.1 17 6.0 0.2 3.2 3 0 0 3 3 3 0 RSD-2 N-terminal domain Hamartin PF04388.12 ETO01930.1 - 1.5 7.4 15.6 1.8 7.1 15.6 1.1 1 0 0 1 1 1 0 Hamartin protein PMC2NT PF08066.12 ETO01931.1 - 0.027 15.1 0.7 29 5.4 0.1 3.2 2 1 0 2 2 2 0 PMC2NT (NUC016) domain APG17 PF04108.12 ETO01931.1 - 0.85 8.7 7.3 7.2 5.6 3.8 2.3 2 1 0 2 2 2 0 Autophagy protein Apg17 YebG PF07130.12 ETO01931.1 - 1.6 8.6 5.2 1 9.3 1.7 2.4 3 0 0 3 3 3 0 YebG protein WD40 PF00400.32 ETO01933.1 - 6.8e-29 99.5 13.6 3.8e-07 30.7 0.3 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO01933.1 - 3.9e-12 45.6 3.2 0.00053 18.8 0.0 3.4 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01933.1 - 4.7e-12 46.1 0.5 0.00054 20.2 0.0 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01933.1 - 0.00011 21.6 0.4 0.17 11.2 0.0 2.5 3 0 0 3 3 3 2 WD40-like domain Fez1 PF06818.15 ETO01934.1 - 0.00057 20.4 19.1 0.016 15.6 3.6 2.0 2 0 0 2 2 2 2 Fez1 TMF_TATA_bd PF12325.8 ETO01934.1 - 0.00061 20.0 26.1 0.038 14.2 8.0 2.1 2 0 0 2 2 2 2 TATA element modulatory factor 1 TATA binding Dynactin_p22 PF07426.11 ETO01934.1 - 0.001 19.0 14.6 0.015 15.2 2.9 2.3 2 0 0 2 2 2 2 Dynactin subunit p22 DUF267 PF03268.14 ETO01934.1 - 0.0013 17.7 0.8 0.002 17.1 0.1 1.6 1 1 1 2 2 2 1 Caenorhabditis protein of unknown function, DUF267 LMBR1 PF04791.16 ETO01934.1 - 0.0033 16.4 1.5 0.0033 16.4 1.5 2.0 1 1 1 2 2 2 1 LMBR1-like membrane protein DUF4972 PF16342.5 ETO01934.1 - 0.0033 17.1 2.2 0.0033 17.1 2.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4972) DUF2207 PF09972.9 ETO01934.1 - 0.0037 16.1 0.1 0.0041 16.0 0.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF2203 PF09969.9 ETO01934.1 - 0.0038 17.9 9.0 0.13 13.0 0.2 2.1 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2203) Nucleoside_tran PF01733.18 ETO01934.1 - 0.0042 16.5 2.5 0.0042 16.5 2.5 1.7 1 1 1 2 2 2 1 Nucleoside transporter HemX PF04375.14 ETO01934.1 - 0.0048 16.2 2.3 0.0048 16.2 2.3 2.0 2 0 0 2 2 2 1 HemX, putative uroporphyrinogen-III C-methyltransferase DUF4337 PF14235.6 ETO01934.1 - 0.0064 16.6 12.3 0.021 14.9 2.8 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4337) DivIC PF04977.15 ETO01934.1 - 0.0067 16.2 0.1 0.0067 16.2 0.1 3.5 2 2 1 3 3 3 1 Septum formation initiator FemAB PF02388.16 ETO01934.1 - 0.0075 15.2 0.4 0.0075 15.2 0.4 2.0 2 0 0 2 2 2 1 FemAB family DUF1664 PF07889.12 ETO01934.1 - 0.0085 16.1 10.8 0.032 14.3 2.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) Sec34 PF04136.15 ETO01934.1 - 0.0091 15.9 20.4 0.21 11.5 7.9 2.2 2 0 0 2 2 2 2 Sec34-like family Spc7 PF08317.11 ETO01934.1 - 0.0096 14.8 23.8 0.023 13.6 8.4 2.0 2 0 0 2 2 2 2 Spc7 kinetochore protein PHM7_cyt PF14703.6 ETO01934.1 - 0.011 16.0 5.4 0.016 15.5 5.4 1.2 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter DUF4003 PF13170.6 ETO01934.1 - 0.013 14.9 3.8 0.013 14.9 3.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4003) GAS PF13851.6 ETO01934.1 - 0.015 14.7 28.4 0.26 10.6 9.1 2.2 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF948 PF06103.11 ETO01934.1 - 0.015 15.5 8.7 0.093 13.0 1.7 2.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) APG6_N PF17675.1 ETO01934.1 - 0.017 15.7 25.8 0.12 12.9 6.2 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region HIP1_clath_bdg PF16515.5 ETO01934.1 - 0.033 14.8 4.4 0.033 14.8 4.4 3.2 2 2 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-K PF11802.8 ETO01934.1 - 0.045 13.3 23.1 0.49 9.9 9.5 2.0 2 0 0 2 2 2 0 Centromere-associated protein K DUF4201 PF13870.6 ETO01934.1 - 0.071 12.8 26.5 0.42 10.3 9.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) FUSC PF04632.12 ETO01934.1 - 0.072 11.6 0.1 0.09 11.3 0.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4446 PF14584.6 ETO01934.1 - 0.089 12.8 8.6 0.072 13.1 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Reticulon PF02453.17 ETO01934.1 - 0.11 12.4 2.5 0.21 11.6 0.6 1.9 1 1 1 2 2 2 0 Reticulon UPF0242 PF06785.11 ETO01934.1 - 0.17 12.0 36.5 0.59 10.2 15.6 2.4 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 ETO01934.1 - 0.23 10.8 28.0 0.14 11.4 9.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Cluap1 PF10234.9 ETO01934.1 - 0.29 10.5 20.1 0.048 13.1 4.3 2.0 2 0 0 2 2 2 0 Clusterin-associated protein-1 COG6 PF06419.11 ETO01934.1 - 0.4 8.9 19.2 0.38 8.9 2.5 2.0 2 0 0 2 2 2 0 Conserved oligomeric complex COG6 KASH_CCD PF14662.6 ETO01934.1 - 0.49 10.2 23.0 0.89 9.4 4.7 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH KIF1B PF12423.8 ETO01934.1 - 0.56 10.7 0.0 0.56 10.7 0.0 2.5 3 1 0 3 3 2 0 Kinesin protein 1B FlaC_arch PF05377.11 ETO01934.1 - 0.58 10.6 16.3 0.26 11.7 1.2 3.6 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) YtxH PF12732.7 ETO01934.1 - 0.65 10.6 6.4 26 5.4 6.4 2.9 1 1 0 1 1 1 0 YtxH-like protein UPF0184 PF03670.13 ETO01934.1 - 0.71 10.3 11.5 3.7 8.0 0.8 2.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) Fmp27_WPPW PF10359.9 ETO01934.1 - 0.97 8.2 16.6 0.15 10.9 3.0 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain HBM PF16591.5 ETO01934.1 - 1.1 8.6 17.7 0.91 8.9 5.4 2.1 2 0 0 2 2 2 0 Helical bimodular sensor domain DHR10 PF18595.1 ETO01934.1 - 1.2 9.2 32.3 0.36 10.9 14.6 2.2 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain T3SSipB PF16535.5 ETO01934.1 - 1.3 9.5 12.1 4.2 7.8 2.0 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB Atg14 PF10186.9 ETO01934.1 - 1.4 8.0 14.5 0.078 12.1 1.9 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 KELK PF15796.5 ETO01934.1 - 1.4 9.5 28.7 1.2 9.7 9.4 3.6 2 2 2 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase COG2 PF06148.11 ETO01934.1 - 1.7 8.7 17.5 3.5 7.7 3.6 2.7 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 KLRAQ PF10205.9 ETO01934.1 - 1.7 8.9 24.6 0.29 11.4 9.7 2.5 2 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein CC2-LZ PF16516.5 ETO01934.1 - 2.1 8.7 24.8 1.1 9.7 8.3 3.4 2 2 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF3584 PF12128.8 ETO01934.1 - 2.3 5.6 22.8 0.87 7.0 7.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) CLN3 PF02487.17 ETO01934.1 - 2.6 7.0 9.9 0.21 10.6 0.7 2.0 1 1 1 2 2 2 0 CLN3 protein YabA PF06156.13 ETO01934.1 - 2.6 8.7 26.9 0.059 14.0 8.2 2.4 2 1 0 2 2 2 0 Initiation control protein YabA DUF812 PF05667.11 ETO01934.1 - 2.7 6.8 25.1 0.64 8.8 10.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Occludin_ELL PF07303.13 ETO01934.1 - 3.1 8.6 17.4 3.4 8.5 5.0 2.5 2 0 0 2 2 2 0 Occludin homology domain Death PF00531.22 ETO01934.1 - 3.2 8.0 10.6 1.2 9.3 2.9 2.6 2 1 0 2 2 2 0 Death domain OmpH PF03938.14 ETO01934.1 - 3.8 7.8 30.6 1.4 9.3 10.0 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DegS PF05384.11 ETO01934.1 - 4 6.9 18.3 4.6 6.7 4.1 2.5 2 1 0 2 2 2 0 Sensor protein DegS HisKA_3 PF07730.13 ETO01934.1 - 4.3 7.9 10.6 2.6 8.7 1.2 2.7 2 1 0 2 2 2 0 Histidine kinase DUF4200 PF13863.6 ETO01934.1 - 4.4 7.7 27.7 5.4 7.4 8.4 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Uso1_p115_C PF04871.13 ETO01934.1 - 4.4 7.7 29.6 1.7 9.0 12.2 2.1 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Sec8_exocyst PF04048.14 ETO01934.1 - 4.6 7.1 15.6 0.73 9.7 2.6 2.6 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain DASH_Duo1 PF08651.10 ETO01934.1 - 4.7 7.0 13.4 4.1 7.2 0.7 3.5 2 2 1 3 3 3 0 DASH complex subunit Duo1 kleA_kleC PF17383.2 ETO01934.1 - 4.8 7.6 8.7 0.61 10.4 1.1 2.5 2 1 0 2 2 2 0 Uncharacterized KorC regulated protein A Seryl_tRNA_N PF02403.22 ETO01934.1 - 4.9 7.4 20.5 12 6.1 8.5 2.8 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain VAPB_antitox PF02697.14 ETO01934.1 - 5.5 7.8 8.4 0.64 10.8 3.1 2.1 2 1 0 2 2 2 0 Putative antitoxin Peptidase_S49_N PF08496.10 ETO01934.1 - 5.5 7.0 12.9 4.2 7.4 2.3 2.2 1 1 1 2 2 2 0 Peptidase family S49 N-terminal TPR_MLP1_2 PF07926.12 ETO01934.1 - 5.9 7.0 29.6 4.7 7.3 12.1 2.4 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein FliJ PF02050.16 ETO01934.1 - 6 7.1 32.0 0.38 11.0 7.9 3.2 2 2 0 2 2 2 0 Flagellar FliJ protein IFT57 PF10498.9 ETO01934.1 - 8.1 5.3 22.3 1.2 8.0 8.4 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Phage_GPO PF05929.11 ETO01934.1 - 8.4 5.9 14.1 0.7 9.5 3.1 2.0 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Mod_r PF07200.13 ETO01934.1 - 8.6 6.5 26.5 2.9 8.0 9.4 2.4 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CENP-F_leu_zip PF10473.9 ETO01934.1 - 8.7 6.4 28.9 5 7.1 13.2 2.3 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fungal_TACC PF12709.7 ETO01934.1 - 8.8 6.9 22.2 0.43 11.1 2.4 3.4 2 2 1 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins ANAPC2 PF08672.11 ETO01934.1 - 9.3 6.9 8.8 0.34 11.5 0.6 2.7 3 0 0 3 3 2 0 Anaphase promoting complex (APC) subunit 2 Zip PF02535.22 ETO01936.1 - 0.0022 17.3 3.8 0.0026 17.0 3.8 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Ctr PF04145.15 ETO01936.1 - 0.0066 17.1 0.1 0.011 16.4 0.1 1.4 1 0 0 1 1 1 1 Ctr copper transporter family Connexin PF00029.19 ETO01936.1 - 0.14 11.9 0.5 0.21 11.3 0.3 1.5 1 1 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 ETO01936.1 - 0.14 10.5 0.4 0.17 10.3 0.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 ETO01936.1 - 0.19 10.6 0.5 0.22 10.4 0.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CSG2 PF16965.5 ETO01936.1 - 0.27 10.1 0.3 0.3 10.0 0.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator NPR3 PF03666.13 ETO01936.1 - 0.96 8.2 7.4 0.95 8.2 7.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO01936.1 - 0.99 7.7 13.4 1.4 7.2 13.4 1.2 1 0 0 1 1 1 0 Menin DNA_pol3_tau_4 PF12168.8 ETO01936.1 - 3.2 8.4 9.4 0.45 11.1 3.4 2.5 2 1 1 3 3 3 0 DNA polymerase III subunits tau domain IV DnaB-binding Shisa PF13908.6 ETO01937.1 - 0.11 12.8 0.5 0.14 12.3 0.5 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EVC2_like PF12297.8 ETO01937.1 - 0.21 10.3 0.8 0.26 9.9 0.8 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Zip PF02535.22 ETO01938.1 - 0.0031 16.8 3.3 0.0036 16.6 3.3 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Ctr PF04145.15 ETO01938.1 - 0.011 16.3 0.1 0.017 15.7 0.1 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Connexin PF00029.19 ETO01938.1 - 0.11 12.2 0.3 0.19 11.4 0.2 1.4 1 1 0 1 1 1 0 Connexin Serinc PF03348.15 ETO01938.1 - 0.18 10.7 0.3 0.21 10.5 0.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) HGTP_anticodon2 PF12745.7 ETO01938.1 - 0.99 8.9 9.5 1.4 8.4 9.5 1.2 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs Menin PF05053.13 ETO01938.1 - 1 7.7 11.2 1.3 7.3 11.2 1.2 1 0 0 1 1 1 0 Menin CRA PF06589.11 ETO01938.1 - 1 9.5 12.4 0.042 13.9 6.4 1.8 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) NPR3 PF03666.13 ETO01938.1 - 1.4 7.7 6.6 1.3 7.7 6.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AlaDh_PNT_N PF05222.15 ETO01939.1 - 4.1e-10 40.1 0.0 0.0013 19.1 0.0 2.3 2 0 0 2 2 2 2 Alanine dehydrogenase/PNT, N-terminal domain Sacchrp_dh_C PF16653.5 ETO01939.1 - 1.5e-08 35.0 0.0 3.1e-08 34.1 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Complex1_LYR_2 PF13233.6 ETO01939.1 - 0.082 13.7 2.2 2.2 9.1 0.5 2.5 1 1 0 2 2 2 0 Complex1_LYR-like Phage_TTP_12 PF16461.5 ETO01939.1 - 0.094 12.4 0.0 0.15 11.7 0.0 1.3 1 0 0 1 1 1 0 Lambda phage tail tube protein, TTP PMP22_Claudin PF00822.20 ETO01939.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.5 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family DUF3654 PF12376.8 ETO01942.1 - 0.0051 17.0 0.3 0.016 15.4 0.3 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3654) Diphtheria_T PF02764.14 ETO01942.1 - 0.41 10.6 2.3 0.47 10.4 1.0 1.8 2 0 0 2 2 2 0 Diphtheria toxin, T domain PPR_2 PF13041.6 ETO01943.1 - 5.1e-05 23.4 1.8 0.029 14.6 0.0 2.8 3 0 0 3 3 3 2 PPR repeat family PPR PF01535.20 ETO01943.1 - 8.4e-05 22.6 2.0 0.093 13.0 0.2 2.9 3 0 0 3 3 3 2 PPR repeat PPR_1 PF12854.7 ETO01943.1 - 0.02 14.6 1.6 0.069 12.9 0.2 2.2 2 0 0 2 2 2 0 PPR repeat PPR_3 PF13812.6 ETO01943.1 - 0.035 14.2 0.5 0.69 10.0 0.1 2.9 3 0 0 3 3 3 0 Pentatricopeptide repeat domain EF_TS PF00889.19 ETO01944.1 - 0.0029 17.2 0.1 0.0036 17.0 0.1 1.1 1 0 0 1 1 1 1 Elongation factor TS TRI5 PF06330.11 ETO01944.1 - 0.012 14.5 0.6 0.014 14.3 0.6 1.1 1 0 0 1 1 1 0 Trichodiene synthase (TRI5) BCAS2 PF05700.11 ETO01944.1 - 0.015 15.0 0.9 0.022 14.5 0.9 1.2 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) Lipoprotein_1 PF00820.19 ETO01944.1 - 0.025 13.7 0.3 0.035 13.2 0.3 1.2 1 0 0 1 1 1 0 Borrelia lipoprotein Receptor_2B4 PF11465.8 ETO01944.1 - 0.086 13.1 0.7 0.15 12.3 0.4 1.4 1 1 0 1 1 1 0 Natural killer cell receptor 2B4 PIN7 PF18475.1 ETO01944.1 - 0.1 13.2 0.7 0.19 12.4 0.2 1.6 2 0 0 2 2 2 0 PIN domain PCI PF01399.27 ETO01944.1 - 0.12 12.9 1.7 0.53 10.8 0.4 2.2 1 1 1 2 2 2 0 PCI domain DUF4441 PF14536.6 ETO01946.1 - 0.0027 17.9 2.7 0.0027 17.9 2.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4441) zf-C4H2 PF10146.9 ETO01946.1 - 0.24 11.7 6.8 0.35 11.1 6.8 1.4 1 1 0 1 1 1 0 Zinc finger-containing protein Allantoicase PF03561.15 ETO01946.1 - 0.41 10.6 1.7 1.1 9.2 0.3 2.1 1 1 1 2 2 2 0 Allantoicase repeat Peptidase_C14 PF00656.22 ETO01947.1 - 2.7e-17 63.6 1.6 7e-17 62.2 1.6 1.7 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO01947.1 - 6.3e-05 22.9 2.9 2.2 8.3 0.4 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO01947.1 - 0.00051 19.6 1.9 1.6 8.4 0.2 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO01947.1 - 0.0011 19.0 1.7 0.028 14.4 0.2 2.7 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO01947.1 - 0.0026 18.0 9.2 0.77 10.1 0.1 4.5 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO01947.1 - 0.062 13.3 4.6 2.9 8.0 0.3 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO01947.1 - 0.53 10.7 1.8 5.7 7.3 0.0 3.1 4 0 0 4 4 4 0 Galactose oxidase, central domain E2F_CC-MB PF16421.5 ETO01947.1 - 4.1 7.8 8.3 0.68 10.3 1.6 3.1 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain B56 PF01603.20 ETO01948.1 - 8.1e-14 51.4 0.7 1e-13 51.1 0.7 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Tubulin PF00091.25 ETO01950.1 - 2.8e-22 79.9 0.1 6.4e-22 78.7 0.1 1.6 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO01950.1 - 4.8e-16 59.1 0.1 1.2e-15 57.8 0.1 1.7 1 0 0 1 1 1 1 Tubulin C-terminal domain Kelch_6 PF13964.6 ETO01951.1 - 7.8e-08 32.3 2.7 0.0042 17.3 0.3 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO01951.1 - 7.5e-07 28.6 2.1 0.00022 20.7 0.3 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO01951.1 - 1.2e-06 28.2 5.4 0.0045 16.9 0.4 5.1 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO01951.1 - 5.6e-05 23.1 1.8 0.00037 20.4 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO01951.1 - 0.00026 20.9 4.3 1.1 9.4 0.8 5.0 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO01951.1 - 0.026 14.8 1.9 0.21 11.9 0.0 3.3 5 0 0 5 5 5 0 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO01951.1 - 0.033 13.3 0.1 0.7 9.0 0.0 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase UPF0180 PF03698.13 ETO01951.1 - 0.096 12.9 0.0 0.57 10.4 0.0 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0180) Methyltransf_11 PF08241.12 ETO01952.1 - 9.7e-18 64.6 0.0 1.1e-17 64.4 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO01952.1 - 1.5e-17 64.1 0.0 1.7e-17 63.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO01952.1 - 2.6e-10 40.3 0.0 3e-10 40.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ETO01952.1 - 2.8e-10 40.1 0.0 3.4e-10 39.9 0.0 1.0 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_23 PF13489.6 ETO01952.1 - 3.9e-10 39.8 0.0 4.4e-10 39.6 0.0 1.0 1 0 0 1 1 1 1 Methyltransferase domain TehB PF03848.14 ETO01952.1 - 1.6e-09 37.5 0.0 1.9e-09 37.2 0.0 1.0 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 ETO01952.1 - 2.6e-09 37.7 0.0 3.1e-09 37.5 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 ETO01952.1 - 8.9e-07 28.6 0.1 1e-06 28.4 0.1 1.0 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase CheR PF01739.18 ETO01952.1 - 0.00059 19.4 0.0 0.00078 19.0 0.0 1.3 1 1 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.14 ETO01952.1 - 0.0012 18.5 0.0 0.0013 18.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ETO01952.1 - 0.0018 17.7 0.0 0.0019 17.5 0.0 1.0 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ETO01952.1 - 0.01 15.3 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase tRNA_U5-meth_tr PF05958.11 ETO01952.1 - 0.018 14.0 0.0 0.025 13.6 0.0 1.3 1 1 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase ODC_AZ PF02100.17 ETO01952.1 - 0.11 12.4 0.1 0.17 11.8 0.1 1.2 1 0 0 1 1 1 0 Ornithine decarboxylase antizyme MMR_HSR1 PF01926.23 ETO01953.1 - 0.02 15.0 0.2 0.062 13.4 0.0 1.9 2 1 0 2 2 2 0 50S ribosome-binding GTPase BAR_3_WASP_bdg PF10456.9 ETO01954.1 - 0.0043 16.6 1.9 0.013 15.0 1.1 2.1 2 1 0 2 2 2 1 WASP-binding domain of Sorting nexin protein DUF3967 PF13152.6 ETO01954.1 - 0.024 14.4 0.5 0.063 13.1 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3967) SF3A3 PF16837.5 ETO01954.1 - 0.074 13.6 0.9 1.2 9.6 0.2 2.5 1 1 1 2 2 2 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 IPPT PF01715.17 ETO01954.1 - 0.21 11.4 2.6 0.34 10.7 2.5 1.7 1 1 0 1 1 1 0 IPP transferase SR-25 PF10500.9 ETO01955.1 - 7.1 6.2 25.5 9.6 5.7 25.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM184 PF15665.5 ETO01958.1 - 1.1e-08 35.2 47.1 1.1e-08 35.2 47.1 8.7 1 1 5 8 8 8 2 Family with sequence similarity 184, A and B pXO2-72 PF17443.2 ETO01958.1 - 0.052 13.8 0.2 0.38 11.0 0.2 2.6 1 0 0 1 1 1 0 Uncharacterized protein pXO2-72 SCO1-SenC PF02630.14 ETO01959.1 - 2.2e-39 134.4 0.1 4.1e-39 133.6 0.1 1.5 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 ETO01959.1 - 0.00048 20.1 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 ETO01959.1 - 0.0012 19.1 0.0 0.0026 18.1 0.0 1.7 1 1 0 1 1 1 1 Thioredoxin-like DUF2615 PF11027.8 ETO01960.1 - 0.00021 21.4 1.2 0.00066 19.8 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2615) FAM176 PF14851.6 ETO01960.1 - 0.012 15.3 0.5 0.041 13.6 0.5 1.9 1 1 0 1 1 1 0 FAM176 family MscL PF01741.18 ETO01960.1 - 0.058 13.7 0.1 3.7 7.9 0.2 2.5 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Menin PF05053.13 ETO01960.1 - 0.18 10.1 5.8 0.24 9.7 5.8 1.1 1 0 0 1 1 1 0 Menin CPP1-like PF11833.8 ETO01960.1 - 0.24 11.0 1.9 0.71 9.5 1.9 1.8 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2457 PF10446.9 ETO01960.1 - 1 8.4 14.9 1.4 8.0 14.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4834 PF16118.5 ETO01961.1 - 0.074 14.0 7.3 0.13 13.3 7.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.22 ETO01961.1 - 0.92 8.7 2.7 0.91 8.7 2.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SAE2 PF08573.10 ETO01961.1 - 1 10.5 11.8 1.4 10.1 11.8 1.2 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Presenilin PF01080.17 ETO01961.1 - 4.2 6.0 10.6 4.5 5.9 10.6 1.1 1 0 0 1 1 1 0 Presenilin DUF1365 PF07103.11 ETO01963.1 - 0.031 13.9 0.0 0.033 13.8 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) ANAPC_CDC26 PF10471.9 ETO01963.1 - 0.35 11.7 4.2 0.47 11.3 4.2 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 ROF PF07073.12 ETO01964.1 - 0.089 13.0 0.6 0.12 12.5 0.5 1.3 1 1 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) ERAP1_C PF11838.8 ETO01965.1 - 1.9e-25 90.1 0.1 6.9e-14 52.1 0.0 2.0 1 1 1 2 2 2 2 ERAP1-like C-terminal domain NACHT PF05729.12 ETO01966.1 - 5e-21 75.3 0.0 8.9e-21 74.5 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO01966.1 - 3.9e-07 29.5 1.5 8.3e-07 28.4 1.5 1.6 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ETO01966.1 - 0.00063 20.2 0.0 0.0019 18.6 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO01966.1 - 0.029 14.7 0.1 0.084 13.1 0.1 1.9 1 1 0 1 1 1 0 AAA domain DUF4286 PF14114.6 ETO01966.1 - 0.036 14.5 0.7 14 6.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4286) ResIII PF04851.15 ETO01966.1 - 0.037 14.0 0.8 0.078 13.0 0.4 1.9 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit Torsin PF06309.11 ETO01966.1 - 0.06 13.4 0.0 0.15 12.2 0.0 1.7 1 0 0 1 1 1 0 Torsin RNA_helicase PF00910.22 ETO01966.1 - 0.061 13.7 0.0 0.53 10.7 0.0 2.5 2 0 0 2 2 2 0 RNA helicase Sigma54_activat PF00158.26 ETO01966.1 - 0.13 12.0 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 ETO01966.1 - 0.13 12.7 0.0 0.69 10.3 0.0 2.1 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) PhoH PF02562.16 ETO01966.1 - 0.14 11.6 0.0 3.1 7.2 0.0 2.3 2 0 0 2 2 2 0 PhoH-like protein DEP PF00610.21 ETO01968.1 - 1.2e-15 57.3 0.3 1.7e-15 56.8 0.3 1.2 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DXPR_C PF13288.6 ETO01968.1 - 0.005 17.1 0.0 0.0064 16.8 0.0 1.3 1 0 0 1 1 1 1 DXP reductoisomerase C-terminal domain STAT_alpha PF01017.20 ETO01969.1 - 0.0069 16.3 9.3 0.0069 16.3 9.3 1.7 2 0 0 2 2 2 1 STAT protein, all-alpha domain HycA_repressor PF11046.8 ETO01969.1 - 0.012 15.8 0.1 0.024 14.9 0.1 1.5 1 0 0 1 1 1 0 Transcriptional repressor of hyc and hyp operons PAM2 PF07145.15 ETO01969.1 - 0.025 14.3 1.2 0.025 14.3 1.2 2.8 2 0 0 2 2 2 0 Ataxin-2 C-terminal region DMPK_coil PF08826.10 ETO01969.1 - 0.11 12.6 7.1 0.21 11.7 0.6 2.5 1 1 0 2 2 2 0 DMPK coiled coil domain like YlqD PF11068.8 ETO01969.1 - 6 7.2 13.7 15 5.9 12.5 2.0 1 1 0 1 1 1 0 YlqD protein FapA PF03961.13 ETO01969.1 - 7.8 5.0 8.6 2.6 6.6 1.2 1.9 1 1 1 2 2 2 0 Flagellar Assembly Protein A KilA-N PF04383.13 ETO01970.1 - 0.28 11.1 5.9 3.5 7.5 0.9 3.1 3 0 0 3 3 3 0 KilA-N domain RPN2_C PF18004.1 ETO01971.1 - 1.9e-38 131.9 9.8 2.4e-38 131.6 9.8 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Methyltransf_15 PF09445.10 ETO01972.1 - 0.02 14.4 0.9 0.02 14.4 0.9 1.9 1 1 1 2 2 2 0 RNA cap guanine-N2 methyltransferase Imm41 PF15592.6 ETO01972.1 - 0.14 12.5 2.1 0.17 12.2 0.4 2.0 1 1 1 2 2 2 0 Immunity protein 41 TRCF PF03461.15 ETO01972.1 - 0.52 10.7 2.6 0.85 10.0 0.1 2.4 3 0 0 3 3 3 0 TRCF domain HEAT PF02985.22 ETO01973.1 - 5.3e-13 48.0 0.0 0.0006 19.9 0.0 4.2 4 0 0 4 4 4 3 HEAT repeat Cnd1 PF12717.7 ETO01973.1 - 1.5e-10 41.3 0.3 0.00026 21.0 0.0 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO01973.1 - 1.8e-07 31.5 0.0 0.0008 19.8 0.0 2.3 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 ETO01973.1 - 3.6e-05 24.2 0.0 0.0027 18.2 0.0 2.7 3 0 0 3 3 3 1 HEAT-like repeat HEAT_PBS PF03130.16 ETO01973.1 - 3.8e-05 23.9 0.0 0.084 13.6 0.0 3.8 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO01973.1 - 5.7e-05 23.6 0.1 0.64 10.7 0.0 2.7 1 1 2 3 3 3 2 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO01973.1 - 9.6e-05 22.2 0.6 1.1 9.0 0.1 3.2 1 1 3 4 4 4 3 TATA-binding protein interacting (TIP20) CLASP_N PF12348.8 ETO01973.1 - 0.00067 19.3 0.1 0.038 13.6 0.0 2.0 2 0 0 2 2 2 1 CLASP N terminal PAS_10 PF13596.6 ETO01973.1 - 0.0054 17.3 0.1 1.1 9.8 0.0 2.9 1 1 2 3 3 3 1 PAS domain Adaptin_N PF01602.20 ETO01973.1 - 0.024 13.2 0.2 0.029 13.0 0.2 1.2 1 0 0 1 1 1 0 Adaptin N terminal region NLE PF08154.12 ETO01973.1 - 0.044 14.3 0.0 3.8 8.1 0.0 2.6 2 0 0 2 2 2 0 NLE (NUC135) domain SAC3_GANP PF03399.16 ETO01973.1 - 0.088 12.2 0.1 8.7 5.6 0.0 2.3 1 1 2 3 3 3 0 SAC3/GANP family DUF3349 PF11829.8 ETO01973.1 - 0.13 13.0 0.3 8 7.3 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) PEX11 PF05648.14 ETO01974.1 - 0.015 14.8 2.0 0.33 10.4 0.3 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Eapp_C PF10238.9 ETO01974.1 - 0.2 11.7 7.4 0.15 12.1 0.8 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein AAA_11 PF13086.6 ETO01974.1 - 0.24 11.1 6.4 0.085 12.6 1.4 2.0 2 0 0 2 2 2 0 AAA domain Peptidase_S49_N PF08496.10 ETO01974.1 - 6.1 6.9 8.1 8.8 6.4 0.8 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal QRPTase_C PF01729.19 ETO01977.1 - 4.1 7.1 7.5 0.64 9.8 3.7 1.5 2 0 0 2 2 2 0 Quinolinate phosphoribosyl transferase, C-terminal domain WD40 PF00400.32 ETO01978.1 - 3.3e-15 56.2 3.9 4.8e-05 24.0 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO01978.1 - 0.0012 17.6 0.4 0.2 10.3 0.3 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO01978.1 - 0.003 17.8 0.1 8.1 6.8 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO01978.1 - 0.016 14.5 4.9 0.36 10.1 0.3 2.2 1 1 1 2 2 2 0 WD40-like domain Beta_helix_2 PF18835.1 ETO01978.1 - 0.16 11.8 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase DUF4457 PF14652.6 ETO01979.1 - 0.021 14.1 6.1 0.025 13.9 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) YPEB PF14620.6 ETO01979.1 - 0.024 14.0 10.1 0.028 13.8 10.1 1.1 1 0 0 1 1 1 0 YpeB sporulation FlgI PF02119.16 ETO01979.1 - 0.091 11.7 5.6 0.12 11.3 5.6 1.1 1 0 0 1 1 1 0 Flagellar P-ring protein Tho2 PF11262.8 ETO01979.1 - 0.16 11.1 13.2 0.19 10.9 13.2 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 TMEM237 PF15383.6 ETO01979.1 - 0.81 8.7 6.6 0.99 8.4 6.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 237 TMPIT PF07851.13 ETO01979.1 - 0.86 8.8 14.0 1 8.6 14.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein CSN5_C PF18323.1 ETO01979.1 - 1.1 10.3 11.1 0.39 11.7 7.8 1.8 1 1 1 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain Exonuc_VII_L PF02601.15 ETO01979.1 - 1.3 8.5 9.4 1.5 8.4 9.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 ETO01979.1 - 3.2 7.9 19.9 7.3 6.8 19.1 1.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HemX PF04375.14 ETO01979.1 - 3.4 6.9 15.8 3.9 6.7 15.8 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase HAUS6_N PF14661.6 ETO01979.1 - 5.2 6.6 14.0 6.1 6.3 14.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Ureide_permease PF07168.11 ETO01979.1 - 5.9 5.5 5.9 6.3 5.4 5.9 1.2 1 0 0 1 1 1 0 Ureide permease Cys_rich_VLP PF14194.6 ETO01981.1 - 0.00043 20.3 0.5 0.00086 19.4 0.5 1.5 1 0 0 1 1 1 1 Cysteine-rich VLP Cys_rich_VLP PF14194.6 ETO01982.1 - 0.00096 19.2 0.5 0.0019 18.3 0.5 1.5 1 0 0 1 1 1 1 Cysteine-rich VLP DUF2569 PF10754.9 ETO01983.1 - 0.0018 18.8 1.1 0.0026 18.2 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2569) AAA_22 PF13401.6 ETO01983.1 - 0.0023 18.2 0.0 0.0041 17.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETO01983.1 - 0.042 13.4 0.1 0.079 12.5 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region Ost4 PF10215.9 ETO01984.1 - 0.011 15.5 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Oligosaccaryltransferase UPF0565 PF10561.9 ETO01986.1 - 0.18 11.0 3.5 0.2 10.8 3.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 PPL5 PF18168.1 ETO01986.1 - 0.27 10.5 5.2 0.32 10.3 5.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 PKI PF02827.16 ETO01986.1 - 0.66 10.2 4.0 1 9.6 4.0 1.3 1 0 0 1 1 1 0 cAMP-dependent protein kinase inhibitor DHHC PF01529.20 ETO01987.1 - 3.7e-19 69.2 9.5 1.2e-18 67.5 9.5 1.8 1 1 0 1 1 1 1 DHHC palmitoyltransferase aGPT-Pplase3 PF18746.1 ETO01987.1 - 0.058 12.7 0.5 0.086 12.2 0.5 1.1 1 0 0 1 1 1 0 Alpha-glutamyl/putrescinyl thymine pyrophosphorylase clade 3 NACHT PF05729.12 ETO01989.1 - 1.1e-18 67.7 0.0 3.3e-18 66.2 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO01989.1 - 0.00045 20.6 0.0 0.0023 18.3 0.0 2.3 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ETO01989.1 - 0.00051 19.3 1.6 0.001 18.3 0.2 2.2 2 1 0 2 2 2 1 NB-ARC domain Lipase_chap PF03280.14 ETO01989.1 - 0.0059 16.6 3.7 0.012 15.6 3.7 1.4 1 0 0 1 1 1 1 Proteobacterial lipase chaperone protein STI1 PF17830.1 ETO01989.1 - 0.022 14.7 0.5 0.19 11.7 0.0 2.8 2 0 0 2 2 2 0 STI1 domain SMC_N PF02463.19 ETO01989.1 - 0.033 13.6 0.1 0.12 11.8 0.0 2.0 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_5 PF07728.14 ETO01989.1 - 0.062 13.3 0.0 1.5 8.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO01989.1 - 0.32 11.3 2.0 1.7 8.9 0.2 2.9 2 1 0 2 2 2 0 AAA domain ABC_membrane PF00664.23 ETO01991.1 - 4.3e-36 125.0 3.2 7.6e-36 124.2 3.2 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ETO01991.1 - 4.2e-20 72.6 2.4 7.9e-17 62.1 0.2 3.3 2 1 0 2 2 2 2 ABC transporter Sensor PF13796.6 ETO01991.1 - 0.0076 16.3 0.6 0.017 15.2 0.6 1.6 1 0 0 1 1 1 1 Putative sensor SRP14 PF02290.15 ETO01991.1 - 0.026 14.9 3.9 0.097 13.0 0.1 3.3 2 1 0 2 2 2 0 Signal recognition particle 14kD protein SMC_N PF02463.19 ETO01991.1 - 0.056 12.9 7.2 0.033 13.6 4.7 1.7 1 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC_tran PF00005.27 ETO01992.1 - 2.1e-20 73.6 0.0 4e-20 72.7 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ETO01992.1 - 0.0089 15.8 0.3 0.023 14.4 0.3 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain SMC_N PF02463.19 ETO01992.1 - 0.18 11.2 1.7 1.4 8.3 1.7 2.1 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO01992.1 - 0.21 12.1 0.0 0.33 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ABC_membrane PF00664.23 ETO01993.1 - 1.6e-29 103.4 5.8 2e-29 103.1 5.8 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region DivIC PF04977.15 ETO01995.1 - 0.13 12.0 2.6 0.24 11.2 2.6 1.4 1 0 0 1 1 1 0 Septum formation initiator DnaJ_C PF01556.18 ETO01996.1 - 3.7e-12 46.6 0.4 2.2e-10 40.8 0.4 2.9 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO01996.1 - 1.1 9.7 11.2 3 8.3 1.7 2.7 2 1 0 2 2 2 0 DnaJ central domain Cob_adeno_trans PF01923.18 ETO01997.1 - 2.4e-46 157.9 0.0 3.3e-46 157.4 0.0 1.2 1 0 0 1 1 1 1 Cobalamin adenosyltransferase Fungal_trans PF04082.18 ETO01997.1 - 0.041 12.9 0.1 0.085 11.9 0.0 1.5 1 1 0 1 1 1 0 Fungal specific transcription factor domain FH2 PF02181.23 ETO02001.1 - 1.3e-72 245.0 14.9 2.7e-72 243.9 14.9 1.5 1 0 0 1 1 1 1 Formin Homology 2 Domain LRR_6 PF13516.6 ETO02002.1 - 2.3e-05 24.1 4.2 0.68 10.1 0.0 5.2 5 0 0 5 5 5 2 Leucine Rich repeat CUE PF02845.16 ETO02002.1 - 0.0012 18.5 1.0 0.0022 17.7 0.0 1.9 2 0 0 2 2 2 1 CUE domain RIB43A PF05914.12 ETO02003.1 - 2.8e-34 118.5 66.6 5.2e-27 94.6 37.9 2.5 1 1 0 2 2 2 2 RIB43A NDUFB11 PF17250.2 ETO02003.1 - 0.1 13.2 0.2 0.1 13.2 0.2 3.6 3 2 1 4 4 4 0 NADH-ubiquinone oxidoreductase 11 kDa subunit TPR_2 PF07719.17 ETO02004.1 - 1.4e-06 27.9 0.1 0.0024 17.8 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02004.1 - 2.5e-06 27.1 0.2 0.0066 16.2 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02004.1 - 0.0015 18.6 0.1 0.18 12.1 0.0 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO02004.1 - 0.0053 17.0 0.2 0.037 14.3 0.1 2.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TAtT PF16811.5 ETO02004.1 - 0.0055 16.0 0.3 0.012 14.9 0.0 1.7 2 0 0 2 2 2 1 TRAP transporter T-component FAT PF02259.23 ETO02004.1 - 0.0081 15.4 1.8 0.015 14.6 1.8 1.4 1 1 0 1 1 1 1 FAT domain MIT PF04212.18 ETO02004.1 - 0.02 15.0 4.3 0.11 12.6 0.4 2.9 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO02004.1 - 0.028 14.8 0.0 0.57 10.7 0.0 2.8 3 1 0 3 3 2 0 Tetratricopeptide repeat POTRA_TamA_1 PF17243.2 ETO02004.1 - 0.045 13.8 2.1 0.25 11.5 0.4 2.6 1 1 2 3 3 3 0 POTRA domain TamA domain 1 TPR_14 PF13428.6 ETO02004.1 - 0.056 14.3 0.3 6.1 7.9 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat CLN3 PF02487.17 ETO02004.1 - 0.22 10.5 0.5 0.49 9.4 0.0 1.7 1 1 1 2 2 2 0 CLN3 protein KinB_sensor PF16767.5 ETO02004.1 - 0.39 11.2 6.8 0.093 13.2 3.5 1.6 2 0 0 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB DUF883 PF05957.13 ETO02004.1 - 1.2 9.8 4.1 23 5.7 0.5 3.0 3 1 1 4 4 3 0 Bacterial protein of unknown function (DUF883) DUF4746 PF15928.5 ETO02005.1 - 0.013 15.0 1.9 0.022 14.2 1.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) HEAT PF02985.22 ETO02009.1 - 8.7e-08 31.8 0.2 0.43 11.0 0.0 6.2 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 ETO02009.1 - 7.9e-06 26.2 0.0 0.0071 16.7 0.0 3.1 2 2 1 3 3 3 2 HEAT repeats DNA_pol3_gamma3 PF12169.8 ETO02009.1 - 0.00034 20.5 2.4 0.27 11.1 0.1 3.4 2 2 2 4 4 4 2 DNA polymerase III subunits gamma and tau domain III DUF5071 PF16804.5 ETO02009.1 - 0.034 14.4 2.3 0.14 12.4 0.1 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF5071) RTP1_C1 PF10363.9 ETO02009.1 - 0.035 14.3 5.4 4.9 7.4 1.1 3.5 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Spore_III_AB PF09548.10 ETO02009.1 - 0.15 12.2 9.0 1.7 8.7 4.1 3.1 1 1 3 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) Y2_Tnp PF04986.13 ETO02009.1 - 0.16 12.0 2.9 0.27 11.2 2.9 1.6 1 1 0 1 1 1 0 Putative transposase ROS_MUCR PF05443.11 ETO02009.1 - 0.27 11.3 2.0 7.8 6.6 0.0 3.1 3 1 0 3 3 3 0 ROS/MUCR transcriptional regulator protein GDNF PF02351.16 ETO02009.1 - 8.1 7.5 11.1 0.95 10.5 3.2 3.0 1 1 1 3 3 3 0 GDNF/GAS1 domain LemA PF04011.12 ETO02010.1 - 0.0087 15.9 0.6 0.076 12.9 0.1 2.3 2 1 0 2 2 2 1 LemA family IL28A PF15177.6 ETO02010.1 - 0.047 13.5 0.2 0.13 12.1 0.0 1.9 2 0 0 2 2 2 0 Interleukin-28A Kelch_6 PF13964.6 ETO02012.1 - 3e-06 27.3 0.1 0.051 13.9 0.2 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO02012.1 - 2e-05 24.5 0.0 0.017 15.1 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO02012.1 - 0.00021 21.2 0.5 0.0075 16.2 0.2 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO02012.1 - 0.00097 18.7 0.1 0.017 14.7 0.0 2.2 2 0 0 2 2 2 1 Kelch motif PB1 PF00564.24 ETO02013.1 - 0.018 14.9 1.8 0.044 13.7 0.5 2.1 2 0 0 2 2 2 0 PB1 domain DUF4646 PF15496.6 ETO02013.1 - 0.26 11.9 0.9 3.4 8.3 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4646) FapA PF03961.13 ETO02016.1 - 0.029 13.0 11.4 0.032 12.8 11.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TT_ORF1 PF02956.14 ETO02016.1 - 0.14 10.8 3.8 0.17 10.6 3.8 1.0 1 0 0 1 1 1 0 TT viral orf 1 PAP_RNA-bind PF04926.15 ETO02016.1 - 0.27 10.8 8.9 2.1 8.0 8.9 1.9 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain Peptidase_S49_N PF08496.10 ETO02016.1 - 0.38 10.8 9.6 0.55 10.3 9.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF932 PF06067.11 ETO02016.1 - 1.3 8.7 5.6 1.9 8.2 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF932) DUF3103 PF11301.8 ETO02016.1 - 2.8 6.6 6.7 3.8 6.2 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3103) Presenilin PF01080.17 ETO02016.1 - 3.7 6.2 5.8 4.3 6.0 5.8 1.1 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 ETO02016.1 - 7.4 6.3 7.1 9.5 5.9 7.1 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus NitrOD5 PF11537.8 ETO02017.1 - 0.11 12.6 0.3 0.19 11.9 0.3 1.4 1 0 0 1 1 1 0 Nitrosopumilus output domain 5 RVT_1 PF00078.27 ETO02018.1 - 3.4e-07 30.0 0.0 4.7e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) PDDEXK_6 PF04720.12 ETO02018.1 - 0.046 13.7 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Arm-DNA-bind_1 PF09003.10 ETO02019.1 - 0.0053 16.9 0.1 0.011 15.9 0.1 1.5 1 1 0 1 1 1 1 Bacteriophage lambda integrase, Arm DNA-binding domain SAM_1 PF00536.30 ETO02020.1 - 0.015 15.7 0.1 0.024 15.1 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DDE_Tnp_1_7 PF13843.6 ETO02020.1 - 0.016 14.5 0.5 0.018 14.4 0.5 1.1 1 0 0 1 1 1 0 Transposase IS4 DUF45 PF01863.17 ETO02020.1 - 0.023 14.7 0.9 0.027 14.5 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF45 CTP_transf_like PF01467.26 ETO02020.1 - 0.17 12.0 0.9 0.25 11.5 0.9 1.3 1 1 0 1 1 1 0 Cytidylyltransferase-like CCDC117 PF15810.5 ETO02021.1 - 0.062 13.6 0.5 0.062 13.6 0.5 2.0 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 117 WD40 PF00400.32 ETO02022.1 - 9.5e-07 29.4 3.4 1.4e-06 28.9 1.8 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02022.1 - 0.046 14.0 0.0 0.16 12.3 0.0 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02022.1 - 0.15 11.3 11.3 0.28 10.5 0.1 2.6 2 1 0 2 2 2 0 WD40-like domain zf-RING_2 PF13639.6 ETO02022.1 - 0.18 12.2 0.4 0.18 12.2 0.4 2.6 2 1 0 2 2 2 0 Ring finger domain WD40 PF00400.32 ETO02023.1 - 5.4e-14 52.4 13.0 6.6e-07 29.9 1.8 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02023.1 - 0.00036 19.3 0.8 0.0041 15.8 0.1 2.2 1 1 0 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02023.1 - 0.0076 16.5 0.2 0.094 13.0 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain zf-RanBP PF00641.18 ETO02024.1 - 5.4e-07 28.8 4.7 1.1e-06 27.8 4.7 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others GatB_Yqey PF02637.18 ETO02025.1 - 0.024 14.5 0.8 1 9.2 0.0 2.4 2 0 0 2 2 2 0 GatB domain SH3_4 PF06347.13 ETO02025.1 - 0.2 11.5 0.0 0.44 10.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain HEAT PF02985.22 ETO02026.1 - 8.8e-20 69.1 4.9 0.00098 19.2 0.0 8.8 9 0 0 9 9 8 3 HEAT repeat HEAT_2 PF13646.6 ETO02026.1 - 7.1e-17 61.6 0.0 4.7e-06 26.9 0.0 6.2 5 1 2 7 7 7 5 HEAT repeats Cnd1 PF12717.7 ETO02026.1 - 1.7e-11 44.4 27.6 0.0022 18.1 1.8 7.5 2 2 4 6 6 6 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO02026.1 - 1.3e-08 35.2 0.0 0.033 14.7 0.0 5.9 4 2 3 7 7 7 2 HEAT-like repeat RTP1_C1 PF10363.9 ETO02026.1 - 2.9e-06 27.4 7.5 0.67 10.2 0.0 6.1 3 3 3 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF4428 PF14471.6 ETO02026.1 - 0.027 14.4 4.6 0.19 11.7 0.4 3.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) HEAT_PBS PF03130.16 ETO02026.1 - 0.031 14.9 0.0 13 6.8 0.0 4.5 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat LpxI_N PF17930.1 ETO02026.1 - 0.036 13.9 0.0 0.17 11.8 0.0 2.2 1 0 0 1 1 1 0 LpxI N-terminal domain Activator-TraM PF11657.8 ETO02026.1 - 0.049 13.5 0.4 1.5 8.6 0.1 2.6 2 0 0 2 2 2 0 Transcriptional activator TraM Complex1_51K PF01512.17 ETO02026.1 - 0.092 12.6 0.1 2 8.3 0.0 2.7 2 0 0 2 2 2 0 Respiratory-chain NADH dehydrogenase 51 Kd subunit XkdW PF09636.10 ETO02026.1 - 0.15 12.2 3.7 19 5.4 0.4 4.6 4 1 0 4 4 4 0 XkdW protein KicB PF03882.14 ETO02026.1 - 0.16 12.2 3.7 46 4.3 0.0 5.1 5 1 0 5 5 5 0 MukF winged-helix domain DUF1308 PF07000.11 ETO02026.1 - 0.19 11.6 1.3 9.2 6.2 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1308) TAN PF11640.8 ETO02026.1 - 1.1 9.4 23.1 0.057 13.6 1.4 6.6 3 2 4 7 7 7 0 Telomere-length maintenance and DNA damage repair WD40 PF00400.32 ETO02027.1 - 7.7e-20 70.9 14.5 2.4e-06 28.2 1.3 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO02027.1 - 3.5e-08 32.6 1.8 0.00011 21.0 0.6 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02027.1 - 5.7e-07 29.7 0.3 0.0088 16.3 0.1 3.1 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02027.1 - 0.00033 20.1 1.0 0.042 13.2 0.1 2.8 1 1 2 3 3 3 2 WD40-like domain Cnd1 PF12717.7 ETO02028.1 - 0.012 15.7 0.0 0.012 15.7 0.0 1.1 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETO02028.1 - 0.098 12.4 0.0 0.11 12.3 0.0 1.1 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) SMC_Nse1 PF07574.13 ETO02028.1 - 0.15 12.0 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Nse1 non-SMC component of SMC5-6 complex Kelch_2 PF07646.15 ETO02030.1 - 7.8e-06 25.7 0.2 0.27 11.3 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO02030.1 - 0.00013 21.5 0.1 0.025 14.2 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO02030.1 - 0.0096 15.9 0.0 0.13 12.3 0.0 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO02030.1 - 0.011 15.8 2.8 13 5.9 0.1 4.9 6 0 0 6 6 6 0 Kelch motif DUF2682 PF10909.8 ETO02031.1 - 0.7 10.4 14.0 0.23 12.0 7.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2682) Ac110_PIF PF07280.11 ETO02032.1 - 0.027 14.3 0.2 0.089 12.6 0.2 1.9 1 0 0 1 1 1 0 Per os infectivity factor AC110 MotB_plug PF13677.6 ETO02032.1 - 0.082 12.5 0.4 0.24 11.0 0.4 1.8 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB CorA PF01544.18 ETO02033.1 - 1.9e-06 27.4 0.3 3.6e-06 26.5 0.3 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3342 PF11822.8 ETO02033.1 - 0.033 14.4 0.0 0.077 13.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) Rota_NS6 PF04866.12 ETO02033.1 - 0.092 13.0 0.4 0.092 13.0 0.4 2.3 2 1 0 2 2 2 0 Rotavirus non-structural protein 6 WD40 PF00400.32 ETO02034.1 - 5.3e-49 163.2 18.8 4.3e-12 46.3 0.6 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02034.1 - 6.6e-21 74.4 2.8 3.4e-06 27.2 0.1 4.6 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02034.1 - 1.4e-12 47.6 1.3 0.00013 21.4 0.1 3.5 1 1 3 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO02034.1 - 1.4e-11 44.6 0.0 0.00011 22.2 0.0 2.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO02034.1 - 1e-06 28.0 0.2 2.2 7.2 0.0 4.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO02034.1 - 1.7e-06 27.0 0.3 0.4 9.3 0.0 3.9 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO02034.1 - 2.4e-06 26.4 4.4 6.1e-05 21.7 1.2 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO02034.1 - 9.9e-05 22.0 0.3 0.00099 18.7 0.2 2.0 1 1 1 2 2 2 2 PQQ-like domain Ret2_MD PF18528.1 ETO02034.1 - 0.0026 18.1 0.1 14 6.1 0.0 3.7 1 1 3 4 4 4 0 RNA editing 3' terminal uridylyl transferase 2 middle domain DUF5122 PF17164.4 ETO02034.1 - 0.0033 17.7 3.1 1.5 9.2 0.0 3.5 4 0 0 4 4 3 2 Domain of unknown function (DUF5122) beta-propeller SGL PF08450.12 ETO02034.1 - 0.0065 16.1 0.0 0.0094 15.5 0.0 1.2 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Glyco_hydro_28 PF00295.17 ETO02034.1 - 0.011 14.8 5.5 0.65 9.0 0.3 2.4 1 1 1 2 2 2 0 Glycosyl hydrolases family 28 Frtz PF11768.8 ETO02034.1 - 0.012 13.9 0.0 0.35 9.1 0.0 2.5 1 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz CvfB_WH PF17783.1 ETO02034.1 - 0.038 13.8 0.4 19 5.1 0.0 3.1 3 0 0 3 3 3 0 CvfB-like winged helix domain Germane PF10646.9 ETO02034.1 - 0.042 14.6 0.1 2.6 8.9 0.0 2.9 3 1 1 4 4 4 0 Sporulation and spore germination Proteasome_A_N PF10584.9 ETO02034.1 - 0.083 12.6 1.7 80 3.1 0.0 4.3 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO02034.1 - 0.086 12.8 0.0 72 3.6 0.0 3.6 4 0 0 4 4 3 0 PQQ enzyme repeat PD40 PF07676.12 ETO02034.1 - 0.12 12.3 3.2 8 6.5 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Peptidase_C9 PF01707.16 ETO02034.1 - 0.14 11.7 0.0 37 3.8 0.0 3.3 1 1 3 4 4 4 0 Peptidase family C9 DUF5014 PF16406.5 ETO02034.1 - 0.17 12.2 0.2 10 6.5 0.0 3.1 4 0 0 4 4 3 0 Domain of unknown function (DUF5014) Prot_ATP_ID_OB PF16450.5 ETO02034.1 - 0.18 11.8 1.1 5.7 7.0 0.1 3.1 3 1 0 3 3 3 0 Proteasomal ATPase OB C-terminal domain Rpn3_C PF08375.11 ETO02034.1 - 0.18 12.2 0.0 13 6.3 0.0 3.3 3 1 1 4 4 4 0 Proteasome regulatory subunit C-terminal DUF3246 PF11596.8 ETO02035.1 - 0.13 11.7 9.1 0.16 11.4 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) CDC45 PF02724.14 ETO02035.1 - 0.2 9.9 12.9 0.23 9.7 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO02035.1 - 1.3 7.0 10.8 1.5 6.8 10.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNA_pol_Rpc4 PF05132.14 ETO02035.1 - 2.8 8.4 7.5 3.4 8.1 7.5 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 NOA36 PF06524.12 ETO02035.1 - 5.9 6.1 13.6 8.9 5.5 13.6 1.3 1 0 0 1 1 1 0 NOA36 protein NOA36 PF06524.12 ETO02036.1 - 0.76 9.0 8.3 0.86 8.9 8.3 1.1 1 0 0 1 1 1 0 NOA36 protein ARD PF03079.14 ETO02036.1 - 0.87 9.8 5.9 1 9.5 5.9 1.1 1 0 0 1 1 1 0 ARD/ARD' family RVT_1 PF00078.27 ETO02037.1 - 1.7e-16 60.4 0.7 2.9e-16 59.7 0.7 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 ETO02039.1 - 6.4e-11 42.6 7.6 0.016 16.1 0.3 4.2 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02039.1 - 0.0041 17.4 0.1 1.5 9.2 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02039.1 - 0.0054 15.4 0.0 0.0093 14.7 0.0 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 WD40 PF00400.32 ETO02042.1 - 1e-11 45.2 0.6 2e-05 25.3 0.0 2.8 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02042.1 - 1.6e-07 30.4 0.1 0.0057 15.4 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02042.1 - 0.0034 17.6 0.0 0.55 10.6 0.0 2.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO02043.1 - 5.9e-08 33.3 0.1 1.8e-07 31.7 0.2 1.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Glyco_hydro_47 PF01532.20 ETO02044.1 - 2.6e-15 56.3 0.6 3.2e-15 56.0 0.6 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 XkdW PF09636.10 ETO02045.1 - 0.0022 18.1 0.0 0.0031 17.6 0.0 1.2 1 0 0 1 1 1 1 XkdW protein RNaseH_like PF04308.12 ETO02045.1 - 0.0068 16.3 0.2 0.016 15.1 0.0 1.6 2 0 0 2 2 2 1 Ribonuclease H-like DUF4277 PF14104.6 ETO02045.1 - 0.014 15.7 0.4 2.1 8.7 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4277) Spt20 PF12090.8 ETO02048.1 - 0.0004 20.1 0.5 0.00049 19.8 0.5 1.1 1 0 0 1 1 1 1 Spt20 family TAS2R PF05296.13 ETO02048.1 - 0.013 14.6 0.9 0.055 12.6 0.6 1.8 2 0 0 2 2 2 0 Taste receptor protein (TAS2R) DUF2207 PF09972.9 ETO02048.1 - 0.076 11.8 1.0 0.089 11.5 0.8 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Peroxin-13_N PF04088.13 ETO02048.1 - 0.082 13.2 0.5 0.14 12.5 0.5 1.5 1 1 0 1 1 1 0 Peroxin 13, N-terminal region PBP1_TM PF14812.6 ETO02048.1 - 0.11 12.8 0.1 0.11 12.8 0.1 2.4 2 1 1 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0139 PF03669.13 ETO02048.1 - 0.72 9.8 2.7 0.92 9.4 0.2 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0139) Orf78 PF06024.12 ETO02048.1 - 9.2 6.6 6.5 2.5 8.4 2.7 2.1 2 1 0 2 2 2 0 Orf78 (ac78) ResIII PF04851.15 ETO02050.1 - 3.3e-07 30.5 0.0 4.6e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 ETO02050.1 - 0.00018 21.2 4.4 0.013 15.1 0.1 2.7 3 0 0 3 3 3 2 DEAD_2 DEAD PF00270.29 ETO02050.1 - 0.00053 19.8 0.0 0.00074 19.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF853 PF05872.12 ETO02050.1 - 0.0095 14.6 0.0 0.013 14.1 0.0 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF853) AAA_11 PF13086.6 ETO02050.1 - 0.011 15.5 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain vWF_A PF12450.8 ETO02050.1 - 0.06 13.3 0.4 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 von Willebrand factor AAA_19 PF13245.6 ETO02050.1 - 0.077 13.3 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain Exog_C PF18026.1 ETO02050.1 - 0.079 13.0 0.0 0.21 11.7 0.0 1.7 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain Rx_N PF18052.1 ETO02050.1 - 0.096 13.0 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 Rx N-terminal domain zf-TRAF PF02176.18 ETO02051.1 - 0.00011 22.8 0.9 0.00011 22.8 0.9 2.5 2 1 0 2 2 2 1 TRAF-type zinc finger PAC1 PF16094.5 ETO02052.1 - 0.14 11.2 1.0 0.17 11.1 1.0 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 HXXEE PF13787.6 ETO02054.1 - 0.04 14.7 3.0 0.047 14.5 3.0 1.1 1 0 0 1 1 1 0 Protein of unknown function with HXXEE motif NIF PF03031.18 ETO02055.1 - 1.4e-21 76.9 0.0 2.2e-21 76.3 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Tim54 PF11711.8 ETO02055.1 - 0.022 13.6 5.6 0.026 13.3 5.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AIF_C PF14721.6 ETO02055.1 - 0.21 12.0 5.5 0.39 11.1 5.5 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RbsD_FucU PF05025.13 ETO02055.1 - 0.24 11.8 2.1 0.37 11.2 0.0 2.0 2 0 0 2 2 2 0 RbsD / FucU transport protein family TFIIA PF03153.13 ETO02055.1 - 0.43 10.5 30.1 0.45 10.5 30.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spore_coat_CotO PF14153.6 ETO02055.1 - 0.46 10.4 20.1 0.57 10.1 20.1 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Ndc1_Nup PF09531.10 ETO02055.1 - 0.67 8.6 8.4 0.61 8.7 8.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.22 ETO02055.1 - 0.91 8.7 3.8 0.92 8.7 3.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 ETO02055.1 - 0.98 9.2 7.9 1 9.1 7.9 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Presenilin PF01080.17 ETO02055.1 - 1 8.0 12.6 1.1 8.0 12.6 1.1 1 0 0 1 1 1 0 Presenilin PepSY_TM PF03929.16 ETO02055.1 - 1.2 8.8 3.9 1.4 8.5 3.9 1.2 1 0 0 1 1 1 0 PepSY-associated TM region CLN3 PF02487.17 ETO02055.1 - 2.9 6.8 7.6 3.4 6.6 7.6 1.1 1 0 0 1 1 1 0 CLN3 protein PAT1 PF09770.9 ETO02055.1 - 2.9 6.0 24.3 3.1 6.0 24.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 MAJIN PF15077.6 ETO02055.1 - 3 7.6 10.0 3.7 7.3 10.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Neur_chan_memb PF02932.16 ETO02055.1 - 8.5 6.3 10.8 11 6.0 10.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LCIB_C_CA PF18599.1 ETO02056.1 - 0.059 12.7 2.7 0.064 12.5 2.7 1.1 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases SurA_N PF09312.11 ETO02056.1 - 0.082 13.0 2.6 0.099 12.7 2.6 1.2 1 0 0 1 1 1 0 SurA N-terminal domain U-box PF04564.15 ETO02057.1 - 8.8e-13 48.2 0.0 3.3e-12 46.4 0.0 2.1 1 0 0 1 1 1 1 U-box domain DUF755 PF05501.11 ETO02058.1 - 4.2 7.7 9.7 2.9 8.2 7.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF755) SR-25 PF10500.9 ETO02058.1 - 5.2 6.6 11.4 8.6 5.9 11.4 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Mucin PF01456.17 ETO02059.1 - 0.21 11.6 60.8 0.021 14.8 4.2 3.6 3 0 0 3 3 3 0 Mucin-like glycoprotein REPA_OB_2 PF16900.5 ETO02060.1 - 1.9e-08 34.1 0.1 1.3e-07 31.5 0.0 2.1 2 0 0 2 2 2 1 Replication protein A OB domain Radial_spoke PF04712.12 ETO02060.1 - 0.00071 18.6 2.8 0.00093 18.3 2.8 1.2 1 0 0 1 1 1 1 Radial spokehead-like protein XRN_M PF17846.1 ETO02060.1 - 0.0057 15.7 1.3 0.0093 15.0 1.3 1.3 1 0 0 1 1 1 1 Xrn1 helical domain tRNA_anti-codon PF01336.25 ETO02060.1 - 0.026 14.5 0.4 5.1 7.2 0.1 3.1 3 1 0 3 3 3 0 OB-fold nucleic acid binding domain FIVAR PF07554.13 ETO02062.1 - 0.0062 17.3 3.3 0.0062 17.3 3.3 2.8 2 0 0 2 2 2 1 FIVAR domain SWIRM PF04433.17 ETO02062.1 - 0.083 13.2 2.0 0.35 11.2 2.0 2.2 1 1 0 1 1 1 0 SWIRM domain Pkinase PF00069.25 ETO02063.1 - 0.00046 19.6 1.6 0.00067 19.1 1.6 1.2 1 0 0 1 1 1 1 Protein kinase domain Methyltrn_RNA_4 PF09936.9 ETO02063.1 - 0.069 13.0 0.0 0.086 12.7 0.0 1.1 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase U-box PF04564.15 ETO02064.1 - 8.5e-09 35.5 0.0 2.4e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 U-box domain Kelch_6 PF13964.6 ETO02064.1 - 0.0018 18.5 0.2 1.3 9.4 0.0 3.3 3 0 0 3 3 3 2 Kelch motif N_Asn_amidohyd PF14736.6 ETO02064.1 - 0.034 13.3 0.1 0.13 11.3 0.1 1.9 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase AAA_16 PF13191.6 ETO02068.1 - 0.14 12.5 0.2 4.3 7.7 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Cid2 PF09774.9 ETO02068.1 - 0.31 11.5 8.6 0.45 10.9 8.6 1.3 1 0 0 1 1 1 0 Caffeine-induced death protein 2 Inhibitor_I53 PF11714.8 ETO02068.1 - 0.38 11.0 5.1 0.84 9.9 5.1 1.5 1 0 0 1 1 1 0 Thrombin inhibitor Madanin Presenilin PF01080.17 ETO02068.1 - 3.4 6.3 9.2 3.8 6.2 9.2 1.1 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO02069.1 - 9.1e-06 26.3 0.1 0.0043 17.8 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02069.1 - 0.061 13.6 0.0 0.099 12.9 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4355 PF14265.6 ETO02070.1 - 0.022 15.0 15.1 0.044 14.0 15.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4355) Herpes_UL20 PF04544.12 ETO02070.1 - 0.062 13.7 0.0 0.074 13.4 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus egress protein UL20 EOS1 PF12326.8 ETO02070.1 - 0.13 12.1 2.2 0.2 11.6 2.2 1.3 1 0 0 1 1 1 0 N-glycosylation protein Connexin PF00029.19 ETO02070.1 - 1.1 9.0 5.2 1.2 8.8 5.2 1.2 1 0 0 1 1 1 0 Connexin CrgA PF06781.12 ETO02070.1 - 1.5 9.0 4.8 3.4 7.8 4.8 1.9 1 1 0 1 1 1 0 Cell division protein CrgA Med19 PF10278.9 ETO02073.1 - 0.87 9.5 19.7 0.86 9.5 19.7 1.0 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 CMS1 PF14617.6 ETO02073.1 - 6.7 6.0 13.9 7.6 5.8 13.9 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF2947 PF11163.8 ETO02074.1 - 0.00078 19.3 2.1 0.18 11.7 0.3 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2947) Ldl_recept_a PF00057.18 ETO02075.1 - 3.7e-10 39.8 25.4 3.5e-06 27.1 5.8 3.2 4 0 0 4 4 4 2 Low-density lipoprotein receptor domain class A HTH_56 PF18662.1 ETO02075.1 - 0.037 14.1 5.1 0.29 11.2 0.1 2.5 2 1 0 2 2 2 0 Cch helix turn helix domain RhoGAP-FF1 PF16512.5 ETO02076.1 - 0.066 13.9 0.6 0.54 11.0 0.0 2.9 3 0 0 3 3 3 0 p190-A and -B Rho GAPs FF domain GDPD PF03009.17 ETO02076.1 - 0.075 12.7 0.2 0.15 11.8 0.2 1.5 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Apo-CIII PF05778.12 ETO02076.1 - 0.19 11.4 1.5 1.5 8.5 0.0 2.8 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) DnaGprimase_HBD PF16730.5 ETO02076.1 - 0.47 10.5 6.0 7.2 6.7 0.1 3.8 3 1 1 4 4 4 0 DnaG-primase C-terminal, helicase-binding domain DUF2605 PF10792.9 ETO02076.1 - 1.5 8.8 6.4 0.5 10.3 0.5 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2605) AAA PF00004.29 ETO02077.1 - 1.1e-06 29.1 0.0 1.7e-06 28.5 0.0 1.4 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO02077.1 - 4.3e-06 26.8 0.0 9e-06 25.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ETO02077.1 - 2.9e-05 24.1 0.2 6e-05 23.1 0.1 1.6 1 1 1 2 2 2 1 AAA domain AAA_8 PF12780.7 ETO02077.1 - 3.5e-05 23.3 0.0 6.5e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 ABC_tran PF00005.27 ETO02077.1 - 0.00082 19.9 0.0 0.00098 19.6 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_2 PF07724.14 ETO02077.1 - 0.0039 17.3 0.1 0.017 15.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO02077.1 - 0.0089 16.3 0.3 0.032 14.5 0.3 1.8 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETO02077.1 - 0.014 14.9 0.0 0.022 14.3 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ETO02077.1 - 0.072 13.5 0.1 0.16 12.4 0.1 1.9 1 1 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 ETO02077.1 - 0.096 13.1 0.2 0.25 11.7 0.2 1.9 1 1 0 1 1 1 0 AAA ATPase domain NTPase_1 PF03266.15 ETO02077.1 - 0.19 11.6 0.5 0.81 9.6 0.0 2.0 2 1 1 3 3 3 0 NTPase RNase_HII PF01351.18 ETO02078.1 - 0.25 11.2 2.6 0.58 10.0 2.6 1.6 1 0 0 1 1 1 0 Ribonuclease HII SPG4 PF17325.2 ETO02078.1 - 0.98 10.5 5.7 4.2 8.5 5.7 2.1 1 0 0 1 1 1 0 Stationary phase protein 4 Enkurin PF13864.6 ETO02079.1 - 0.049 14.1 1.1 0.21 12.0 1.1 2.2 1 0 0 1 1 1 0 Calmodulin-binding Fib_alpha PF08702.10 ETO02079.1 - 0.088 13.0 0.4 0.95 9.6 0.1 2.7 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Mac PF12464.8 ETO02079.1 - 0.2 11.9 3.1 0.46 10.8 0.1 2.9 3 0 0 3 3 3 0 Maltose acetyltransferase DUF883 PF05957.13 ETO02081.1 - 0.0071 16.9 4.7 0.0071 16.9 4.7 4.1 1 1 3 4 4 4 1 Bacterial protein of unknown function (DUF883) TPR_MLP1_2 PF07926.12 ETO02081.1 - 0.22 11.6 72.1 0.29 11.2 18.2 3.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO02081.1 - 0.24 10.7 46.6 0.0065 15.9 22.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ADIP PF11559.8 ETO02081.1 - 2.1 8.4 83.9 0.41 10.7 26.4 4.9 1 1 4 5 5 5 0 Afadin- and alpha -actinin-Binding DUF3584 PF12128.8 ETO02081.1 - 5.3 4.4 67.7 7.6 3.9 67.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 ETO02081.1 - 7.7 7.1 79.1 7.4 7.1 24.5 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region NTPase_1 PF03266.15 ETO02082.1 - 0.11 12.4 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 NTPase Cnd1 PF12717.7 ETO02083.1 - 0.007 16.4 3.7 0.28 11.2 0.0 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO02083.1 - 0.0073 16.5 0.1 4.4 7.8 0.0 3.3 3 0 0 3 3 3 1 HEAT repeat RTP1_C1 PF10363.9 ETO02083.1 - 0.027 14.7 0.0 3.2 8.0 0.0 2.2 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 AvrM-A PF18241.1 ETO02083.1 - 0.064 13.7 6.3 0.053 13.9 3.3 1.9 1 1 1 2 2 2 0 Flax-rust effector AvrM-A TAF6_C PF07571.13 ETO02083.1 - 0.16 12.3 0.5 5.6 7.4 0.2 2.4 1 1 1 2 2 2 0 TAF6 C-terminal HEAT repeat domain HEAT PF02985.22 ETO02085.1 - 9.3e-18 62.8 0.3 0.0024 18.0 0.0 7.3 8 0 0 8 8 7 3 HEAT repeat HEAT_2 PF13646.6 ETO02085.1 - 8.4e-15 54.9 0.0 2.6e-06 27.7 0.0 5.3 4 1 1 5 5 5 3 HEAT repeats RTP1_C1 PF10363.9 ETO02085.1 - 1.4e-08 34.9 2.2 0.056 13.6 0.0 5.3 4 2 1 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETO02085.1 - 3.4e-07 30.5 23.9 0.0016 18.5 0.0 6.0 1 1 4 6 6 6 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO02085.1 - 1.4e-06 28.7 0.0 0.001 19.5 0.0 4.6 5 1 1 6 6 6 1 HEAT-like repeat ENTH PF01417.20 ETO02085.1 - 0.00029 20.9 10.7 0.049 13.7 2.4 4.6 3 2 1 4 4 4 1 ENTH domain CLASP_N PF12348.8 ETO02085.1 - 0.00052 19.7 14.0 0.0041 16.7 0.2 4.1 3 2 0 4 4 4 2 CLASP N terminal Spore_IV_A PF09547.10 ETO02085.1 - 0.0013 17.8 0.8 0.0013 17.8 0.8 1.8 2 0 0 2 2 2 1 Stage IV sporulation protein A (spore_IV_A) HEAT_PBS PF03130.16 ETO02085.1 - 0.01 16.4 0.0 0.7 10.7 0.0 3.3 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat DNA_pol3_gamma3 PF12169.8 ETO02085.1 - 0.041 13.8 0.1 8.3 6.3 0.0 3.5 3 0 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III Tudor_RapA PF18337.1 ETO02085.1 - 0.066 13.4 0.4 1.5 9.1 0.0 3.1 3 0 0 3 3 2 0 RapA N-terminal Tudor like domain Vac14_Fab1_bd PF12755.7 ETO02085.1 - 0.09 13.4 9.2 1.7 9.3 0.1 5.1 4 2 3 7 7 7 0 Vacuolar 14 Fab1-binding region DNA_alkylation PF08713.11 ETO02085.1 - 0.27 10.9 7.2 2.9 7.6 0.0 3.5 3 2 1 4 4 4 0 DNA alkylation repair enzyme CDC37_M PF08565.11 ETO02085.1 - 0.75 9.7 11.3 0.56 10.1 0.2 4.5 2 1 1 3 3 3 0 Cdc37 Hsp90 binding domain DUF3349 PF11829.8 ETO02085.1 - 0.75 10.6 3.7 17 6.3 0.1 4.2 3 2 2 5 5 5 0 Protein of unknown function (DUF3349) Syntaphilin PF15290.6 ETO02085.1 - 1.3 8.6 7.1 0.22 11.2 0.2 2.6 3 0 0 3 3 3 0 Golgi-localised syntaxin-1-binding clamp IPK PF03770.16 ETO02085.1 - 2.2 8.1 14.4 0.25 11.2 5.2 3.4 2 1 1 4 4 4 0 Inositol polyphosphate kinase RsfS PF02410.15 ETO02085.1 - 4 7.9 5.4 5 7.6 0.1 3.5 3 3 0 3 3 3 0 Ribosomal silencing factor during starvation SIP1 PF04938.12 ETO02085.1 - 5.6 6.6 13.5 0.51 10.0 0.4 3.8 3 1 1 4 4 4 0 Survival motor neuron (SMN) interacting protein 1 (SIP1) DUF3484 PF11983.8 ETO02087.1 - 0.19 12.9 0.4 0.68 11.1 0.0 2.0 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch zf-C2HE PF16278.5 ETO02088.1 - 0.019 15.4 1.4 0.019 15.4 1.4 2.0 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger MRP-S32 PF10210.9 ETO02088.1 - 0.06 13.9 1.3 0.1 13.1 0.2 1.8 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S32 NPV_P10 PF05531.12 ETO02088.1 - 0.09 13.2 3.4 0.14 12.6 2.6 1.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein YlbD_coat PF14071.6 ETO02088.1 - 0.094 13.0 4.3 0.082 13.2 2.8 1.6 1 1 0 1 1 1 0 Putative coat protein DUF4533 PF15047.6 ETO02088.1 - 0.34 10.5 5.9 0.072 12.6 2.6 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4533) Rootletin PF15035.6 ETO02090.1 - 0.011 15.7 17.8 1.2 9.1 17.8 2.1 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Nsp1_C PF05064.13 ETO02090.1 - 0.034 13.9 1.7 0.034 13.9 1.7 2.7 2 1 1 3 3 3 0 Nsp1-like C-terminal region Syntaxin_2 PF14523.6 ETO02090.1 - 0.33 11.4 13.1 0.29 11.5 0.5 2.5 2 1 0 2 2 2 0 Syntaxin-like protein KxDL PF10241.9 ETO02090.1 - 1.5 9.1 13.9 0.083 13.2 5.8 2.6 2 1 1 3 3 3 0 Uncharacterized conserved protein Swi5 PF07061.11 ETO02090.1 - 2.1 8.5 15.7 14 5.8 0.3 3.2 2 1 1 3 3 3 0 Swi5 DUF489 PF04356.12 ETO02090.1 - 2.4 8.1 8.6 0.49 10.4 4.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF489) DUF948 PF06103.11 ETO02090.1 - 2.9 8.2 5.0 5.4 7.3 0.2 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Ntox28 PF15605.6 ETO02090.1 - 3.4 7.9 8.1 0.67 10.2 2.3 2.4 1 1 2 3 3 3 0 Bacterial toxin 28 Fib_alpha PF08702.10 ETO02090.1 - 3.7 7.7 15.7 1.5 9.0 11.1 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family COG2 PF06148.11 ETO02090.1 - 4.4 7.4 11.5 1.8 8.6 4.7 2.4 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1043 PF06295.12 ETO02090.1 - 4.7 7.2 18.9 8 6.5 10.7 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) DUF1664 PF07889.12 ETO02090.1 - 6.3 6.9 11.5 2 8.5 5.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) YtxH PF12732.7 ETO02090.1 - 7 7.3 5.5 9 6.9 0.3 2.6 2 1 0 2 2 2 0 YtxH-like protein ALMT PF11744.8 ETO02090.1 - 7 5.4 8.5 8 5.2 8.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter UPF0242 PF06785.11 ETO02090.1 - 7.2 6.7 21.2 15 5.6 0.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PP2C_C PF07830.13 ETO02090.1 - 9.3 6.8 9.3 4.5 7.8 0.4 2.5 2 1 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain CAF1A PF12253.8 ETO02091.1 - 0.19 11.9 5.0 0.34 11.1 5.0 1.6 1 1 0 1 1 1 0 Chromatin assembly factor 1 subunit A Macoilin PF09726.9 ETO02091.1 - 0.22 10.1 12.7 0.23 10.0 12.7 1.0 1 0 0 1 1 1 0 Macoilin family GET2 PF08690.10 ETO02091.1 - 0.43 10.2 9.9 0.56 9.8 9.9 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 MDFI PF15316.6 ETO02091.1 - 0.47 10.5 9.1 0.6 10.2 9.1 1.1 1 0 0 1 1 1 0 MyoD family inhibitor RR_TM4-6 PF06459.12 ETO02091.1 - 0.86 9.4 12.6 1 9.1 12.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 ETO02091.1 - 7.4 4.6 11.7 8.1 4.4 11.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein zf-C2H2_3rep PF18868.1 ETO02091.1 - 7.6 7.2 8.2 1.7 9.4 2.8 2.0 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats MIEAP PF16026.5 ETO02092.1 - 6.7e-10 39.5 0.2 2.5e-09 37.7 0.0 1.9 2 0 0 2 2 2 1 Mitochondria-eating protein RuvB_N PF05496.12 ETO02093.1 - 0.09 12.5 0.0 0.13 12.0 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain MAP17 PF15807.5 ETO02094.1 - 0.17 12.2 6.8 0.31 11.3 6.8 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Tau95_N PF17682.1 ETO02094.1 - 0.39 10.9 5.8 0.58 10.3 5.5 1.5 1 1 0 1 1 1 0 Tau95 Triple barrel domain WD40 PF00400.32 ETO02095.1 - 2.4e-57 189.5 17.1 1.9e-09 38.0 0.1 8.2 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02095.1 - 1.3e-24 86.3 3.5 0.0013 18.9 0.1 7.0 3 1 5 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02095.1 - 2.5e-13 50.1 14.9 2.9e-05 23.5 0.0 5.7 4 1 3 7 7 7 4 WD40-like domain Ge1_WD40 PF16529.5 ETO02095.1 - 1.6e-11 43.8 4.6 0.14 11.0 0.0 6.9 3 1 5 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO02095.1 - 6.6e-09 34.9 2.5 0.055 12.1 0.0 5.1 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO02095.1 - 5.8e-08 31.7 0.1 0.0001 21.0 0.0 2.4 1 1 1 2 2 2 2 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO02095.1 - 3.1e-05 23.8 2.2 0.039 13.9 0.1 4.5 4 0 0 4 4 4 1 Kelch motif VID27 PF08553.10 ETO02095.1 - 3.9e-05 22.9 0.0 0.043 12.9 0.0 2.9 1 1 2 3 3 3 2 VID27 C-terminal WD40-like domain Kelch_6 PF13964.6 ETO02095.1 - 0.00051 20.2 6.4 1.2 9.6 0.1 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO02095.1 - 0.00063 19.3 2.1 2.6 7.7 0.0 3.8 4 0 0 4 4 4 2 Kelch motif PALB2_WD40 PF16756.5 ETO02095.1 - 0.0018 17.3 2.0 6.8 5.5 0.0 4.5 2 2 3 5 5 5 1 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO02095.1 - 0.044 13.7 6.4 1.2e+02 2.8 0.0 6.2 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat ArlS_N PF18719.1 ETO02095.1 - 0.069 13.4 0.2 0.51 10.5 0.0 2.5 2 1 1 3 3 3 0 ArlS sensor domain PQQ_2 PF13360.6 ETO02095.1 - 0.15 11.7 0.0 3.1 7.3 0.0 2.3 1 1 1 2 2 2 0 PQQ-like domain Kelch_1 PF01344.25 ETO02096.1 - 8.2e-08 31.7 0.3 0.00037 20.0 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO02096.1 - 2.5e-05 24.0 0.1 0.18 11.9 0.2 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO02096.1 - 3.2e-05 23.8 0.1 0.69 10.0 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO02096.1 - 4.6e-05 23.4 0.0 0.044 13.8 0.0 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO02096.1 - 0.016 15.5 0.4 10 6.6 0.0 3.2 3 0 0 3 3 3 0 Kelch motif HTH_Tnp_Tc3_2 PF01498.18 ETO02097.1 - 2.4e-05 24.5 1.8 3e-05 24.2 0.2 2.1 2 1 0 2 2 2 1 Transposase HTH_23 PF13384.6 ETO02097.1 - 0.0081 15.9 0.1 0.023 14.5 0.0 1.8 2 0 0 2 2 2 1 Homeodomain-like domain PAX PF00292.18 ETO02097.1 - 0.029 14.3 0.0 0.056 13.4 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain HTH_7 PF02796.15 ETO02097.1 - 0.075 13.1 0.2 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase LZ_Tnp_IS481 PF13011.6 ETO02097.1 - 0.077 13.5 0.1 0.13 12.9 0.1 1.3 1 0 0 1 1 1 0 leucine-zipper of insertion element IS481 BrkDBD PF09607.10 ETO02097.1 - 0.19 11.5 0.1 0.19 11.5 0.1 1.8 2 0 0 2 2 2 0 Brinker DNA-binding domain DUF4175 PF13779.6 ETO02099.1 - 0.19 9.6 0.3 0.22 9.4 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Ribosomal_L22e PF01776.17 ETO02103.1 - 0.0026 18.1 0.4 0.0061 16.9 0.4 1.6 1 0 0 1 1 1 1 Ribosomal L22e protein family DUF4825 PF16107.5 ETO02104.1 - 0.01 15.9 0.0 0.019 15.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4825) WD40 PF00400.32 ETO02105.1 - 2.5e-09 37.6 4.6 0.0024 18.7 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02105.1 - 0.0012 19.1 0.1 0.5 10.7 0.0 3.1 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02105.1 - 0.013 14.1 0.3 0.026 13.2 0.3 1.4 1 1 0 1 1 1 0 Nucleoporin Nup120/160 Plk4_PB1 PF18190.1 ETO02106.1 - 0.019 15.1 2.0 0.07 13.3 0.1 2.0 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 1 WD40 PF00400.32 ETO02107.1 - 1e-05 26.2 14.5 0.36 11.8 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat Presenilin PF01080.17 ETO02107.1 - 1.5 7.5 12.4 2.2 6.9 3.3 2.3 2 0 0 2 2 2 0 Presenilin DUF4394 PF14339.6 ETO02110.1 - 0.052 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) MMS19_C PF12460.8 ETO02111.1 - 1.6e-09 37.4 7.7 1.6e-09 37.4 7.7 1.7 1 1 1 2 2 2 1 RNAPII transcription regulator C-terminal Sod_Ni PF09055.11 ETO02111.1 - 0.023 15.2 1.9 0.029 14.9 0.3 2.0 2 0 0 2 2 2 0 Nickel-containing superoxide dismutase MMS19_N PF14500.6 ETO02112.1 - 7.3e-26 91.3 1.9 7.3e-26 91.3 1.9 1.5 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II FliS PF02561.14 ETO02112.1 - 0.2 11.9 0.4 2.2 8.6 0.1 2.2 2 0 0 2 2 2 0 Flagellar protein FliS PGA2 PF07543.12 ETO02114.1 - 0.043 13.8 1.4 0.11 12.5 0.1 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF3090 PF11290.8 ETO02114.1 - 0.077 12.8 0.1 0.097 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) WD40 PF00400.32 ETO02115.1 - 4.1e-33 112.9 25.8 3.6e-07 30.8 2.4 6.1 5 1 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO02115.1 - 2e-10 40.0 9.5 0.0096 14.6 0.4 4.6 1 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02115.1 - 5.2e-10 39.5 2.9 0.49 10.7 0.0 5.5 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Cyto_heme_lyase PF01265.17 ETO02116.1 - 3.7e-18 66.2 7.4 3.7e-18 66.2 7.4 4.1 1 1 3 4 4 4 2 Cytochrome c/c1 heme lyase HMD PF03201.16 ETO02116.1 - 0.19 12.0 0.0 0.33 11.2 0.0 1.3 1 0 0 1 1 1 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase WD40 PF00400.32 ETO02117.1 - 2.5e-67 221.1 18.0 1.1e-11 45.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02117.1 - 1.1e-21 76.9 4.7 0.0046 17.2 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02117.1 - 4.4e-11 42.6 0.3 0.0042 16.5 0.1 3.4 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO02117.1 - 5.6e-10 38.7 0.1 0.24 10.3 0.0 6.0 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO02117.1 - 1.5e-09 37.1 3.7 0.025 13.3 0.0 5.4 3 3 3 6 6 6 4 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO02117.1 - 1.7e-08 34.6 1.7 5 7.2 0.0 6.0 1 1 5 6 6 6 1 Family of unknown function (DUF5570) BBS2_Mid PF14783.6 ETO02117.1 - 0.00019 21.4 4.7 2.2 8.4 0.1 5.4 3 3 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 ETO02117.1 - 0.00066 19.6 0.2 2.4 8.2 0.0 4.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO02117.1 - 0.015 15.2 0.0 30 4.8 0.0 4.5 5 0 0 5 5 5 0 PQQ enzyme repeat Ricin_B_lectin PF00652.22 ETO02117.1 - 0.028 14.7 4.9 0.51 10.6 0.1 3.2 1 1 3 4 4 4 0 Ricin-type beta-trefoil lectin domain WD40 PF00400.32 ETO02118.1 - 1.8e-56 186.8 17.1 3.6e-09 37.1 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02118.1 - 2e-22 79.3 1.1 0.0074 16.6 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO02118.1 - 3e-11 42.9 1.2 0.0013 17.8 0.1 5.6 2 2 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO02118.1 - 5.3e-08 32.0 2.5 0.8 8.3 0.0 5.1 3 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO02118.1 - 1.8e-07 30.8 1.5 0.095 12.0 0.0 3.5 2 2 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO02118.1 - 2.5e-06 27.3 0.7 9.1 6.4 0.0 5.5 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO02118.1 - 8.9e-05 21.4 1.1 0.57 8.9 0.3 3.6 1 1 2 3 3 3 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region MMS1_N PF10433.9 ETO02118.1 - 0.00043 19.0 0.0 1.6 7.3 0.0 3.3 1 1 1 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Phage_CI_repr PF07022.13 ETO02118.1 - 0.0013 18.8 0.9 2.6 8.2 0.2 3.5 3 1 0 3 3 3 1 Bacteriophage CI repressor helix-turn-helix domain DUF1513 PF07433.11 ETO02118.1 - 0.0033 16.6 0.2 0.53 9.3 0.0 3.5 1 1 1 3 3 3 1 Protein of unknown function (DUF1513) HARP PF07443.13 ETO02118.1 - 0.025 14.2 0.0 31 4.3 0.0 3.5 4 0 0 4 4 4 0 HepA-related protein (HARP) DUF1854 PF08909.11 ETO02118.1 - 0.067 13.0 0.3 1.4 8.7 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1854) IFT46_B_C PF12317.8 ETO02121.1 - 0.22 11.2 3.6 0.38 10.5 3.6 1.3 1 0 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal NACHT PF05729.12 ETO02122.1 - 7e-18 65.1 0.0 1.2e-17 64.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO02122.1 - 8.5e-05 21.9 2.7 0.00019 20.7 2.7 1.6 1 1 0 1 1 1 1 NB-ARC domain Sec23_helical PF04815.15 ETO02122.1 - 0.00056 19.7 0.7 0.061 13.1 0.0 2.6 2 0 0 2 2 2 1 Sec23/Sec24 helical domain AAA_22 PF13401.6 ETO02122.1 - 0.00072 19.8 0.2 0.0097 16.2 0.2 2.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO02122.1 - 0.0097 16.3 0.0 0.057 13.8 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 ETO02122.1 - 0.15 11.8 0.0 0.74 9.5 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain BLOC1_2 PF10046.9 ETO02124.1 - 0.0029 17.9 22.0 0.53 10.6 6.2 3.0 1 1 2 3 3 3 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 EzrA PF06160.12 ETO02124.1 - 0.0038 15.5 22.0 0.0095 14.2 22.0 1.7 1 1 0 1 1 1 1 Septation ring formation regulator, EzrA Filament PF00038.21 ETO02124.1 - 0.01 15.5 19.2 0.071 12.7 14.0 2.0 2 0 0 2 2 2 1 Intermediate filament protein 30K_MP_core PF17644.1 ETO02124.1 - 0.023 14.6 0.1 1.9 8.3 0.0 2.3 1 1 1 2 2 2 0 Core domain of 30K viral movement proteins T3SSipB PF16535.5 ETO02124.1 - 0.023 15.2 8.0 1.8 9.1 6.4 2.2 2 0 0 2 2 2 0 Type III cell invasion protein SipB Seryl_tRNA_N PF02403.22 ETO02124.1 - 0.024 14.8 21.9 0.1 12.8 15.6 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HIP1_clath_bdg PF16515.5 ETO02124.1 - 0.026 15.1 20.2 0.88 10.2 0.4 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF16 PF01519.16 ETO02124.1 - 0.034 14.6 30.6 0.052 14.0 9.8 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 HAUS-augmin3 PF14932.6 ETO02124.1 - 0.038 13.6 17.9 0.009 15.6 12.9 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF2115 PF09888.9 ETO02124.1 - 0.057 13.9 7.3 0.037 14.6 5.6 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) CCDC-167 PF15188.6 ETO02124.1 - 0.072 13.4 22.4 0.72 10.2 0.5 3.2 1 1 2 3 3 3 0 Coiled-coil domain-containing protein 167 GAS PF13851.6 ETO02124.1 - 0.073 12.4 31.2 0.14 11.5 22.2 2.1 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 ETO02124.1 - 0.1 12.6 33.1 0.21 11.6 9.4 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Fungal_trans_2 PF11951.8 ETO02124.1 - 0.11 11.3 1.7 0.13 11.0 1.7 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain Jnk-SapK_ap_N PF09744.9 ETO02124.1 - 0.13 12.4 19.1 0.16 12.2 14.7 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 AAA_13 PF13166.6 ETO02124.1 - 0.14 10.8 17.1 0.12 11.0 10.7 2.1 2 0 0 2 2 2 0 AAA domain TPR_MLP1_2 PF07926.12 ETO02124.1 - 0.19 11.8 26.5 0.3 11.2 14.8 2.7 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4509 PF14970.6 ETO02124.1 - 0.2 11.6 14.2 8 6.3 8.9 2.9 1 1 0 2 2 2 0 Domain of unknown function (DUF4509) DUF4515 PF14988.6 ETO02124.1 - 0.32 10.8 30.3 3 7.6 19.2 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) LXG PF04740.12 ETO02124.1 - 0.47 10.1 20.8 0.2 11.3 0.4 3.9 2 1 1 3 3 3 0 LXG domain of WXG superfamily DUF4996 PF16387.5 ETO02124.1 - 0.49 10.9 4.8 1.9 9.1 0.1 2.7 1 1 1 2 2 2 0 Domain of unknown function CorA PF01544.18 ETO02124.1 - 0.51 9.6 6.7 0.7 9.2 6.7 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF2203 PF09969.9 ETO02124.1 - 0.78 10.5 13.3 2e+02 2.7 13.3 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) ZapB PF06005.12 ETO02124.1 - 1 9.9 25.3 0.63 10.5 17.1 2.5 1 1 2 3 3 3 0 Cell division protein ZapB Chordopox_L2 PF05803.12 ETO02124.1 - 1.1 9.1 5.3 0.97 9.3 0.1 2.6 2 1 1 3 3 3 0 Chordopoxvirus L2 protein APG6_N PF17675.1 ETO02124.1 - 1.3 9.5 26.7 0.28 11.7 18.9 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region CHASE3 PF05227.13 ETO02124.1 - 1.6 8.7 10.6 6.2 6.7 7.3 2.8 1 1 1 2 2 2 0 CHASE3 domain DUF948 PF06103.11 ETO02124.1 - 2.1 8.7 11.4 6.1 7.2 5.5 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Mod_r PF07200.13 ETO02124.1 - 2.3 8.3 24.4 18 5.5 0.0 3.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein YlqD PF11068.8 ETO02124.1 - 2.8 8.3 27.4 5.1 7.5 17.8 2.8 1 1 1 2 2 2 0 YlqD protein HOOK PF05622.12 ETO02124.1 - 2.8 6.0 27.2 2.4 6.2 18.7 2.2 1 1 1 2 2 2 0 HOOK protein DUF2968 PF11180.8 ETO02124.1 - 3 7.4 18.5 0.64 9.6 13.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) ATG16 PF08614.11 ETO02124.1 - 3.2 7.9 20.6 13 5.9 15.4 2.5 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 ETO02124.1 - 4.9 6.4 21.6 11 5.3 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) V_ATPase_I PF01496.19 ETO02124.1 - 5.1 4.9 13.8 6.3 4.6 13.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 ETO02124.1 - 5.7 6.1 22.0 9.1 5.4 20.1 1.9 1 1 0 1 1 1 0 TMPIT-like protein bZIP_1 PF00170.21 ETO02124.1 - 6.6 6.9 28.0 0.28 11.3 4.3 4.1 2 1 3 5 5 5 0 bZIP transcription factor DivIC PF04977.15 ETO02124.1 - 6.8 6.5 32.0 0.47 10.2 9.7 4.0 1 1 3 4 4 4 0 Septum formation initiator Med9 PF07544.13 ETO02124.1 - 6.8 6.9 28.7 4 7.6 6.1 3.9 2 1 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 Mt_ATP-synt_D PF05873.12 ETO02124.1 - 8.1 6.3 17.5 2 8.3 11.0 2.4 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Fib_alpha PF08702.10 ETO02124.1 - 8.8 6.5 24.4 4.7 7.4 16.4 2.6 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Kelch_1 PF01344.25 ETO02125.1 - 0.0035 16.9 0.7 2.7 7.6 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Urocanase_C PF17392.2 ETO02125.1 - 0.091 12.2 0.0 9.1 5.7 0.0 2.6 2 1 1 3 3 3 0 Urocanase C-terminal domain DUF4619 PF15398.6 ETO02130.1 - 0.11 12.0 0.2 0.17 11.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4619) GTP_EFTU_D2 PF03144.25 ETO02131.1 - 1.4e-07 31.8 0.1 2.6e-07 31.0 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ETO02131.1 - 4.6e-06 26.4 0.1 7.9e-06 25.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Arm-DNA-bind_5 PF17293.2 ETO02133.1 - 0.041 14.3 0.6 0.098 13.1 0.6 1.6 1 0 0 1 1 1 0 Arm DNA-binding domain Comm PF15957.5 ETO02133.1 - 0.56 10.6 5.8 4.7 7.6 0.1 2.4 1 1 1 2 2 2 0 Commissureless FcoT PF10862.8 ETO02134.1 - 0.043 13.4 0.7 0.051 13.2 0.6 1.3 1 1 0 1 1 1 0 FcoT-like thioesterase domain CPSase_L_D3 PF02787.19 ETO02134.1 - 0.047 14.0 2.0 0.072 13.4 2.0 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain Thymidylate_kin PF02223.17 ETO02135.1 - 3.3e-34 118.2 2.4 1.2e-21 77.3 0.3 2.3 2 1 0 2 2 2 2 Thymidylate kinase dNK PF01712.19 ETO02135.1 - 8.7e-06 25.7 2.9 1.2e-05 25.2 2.9 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase KTI12 PF08433.10 ETO02135.1 - 0.0017 17.8 1.1 0.0099 15.3 1.0 2.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_14 PF13173.6 ETO02135.1 - 0.0026 17.8 2.6 0.11 12.6 0.3 2.4 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO02135.1 - 0.0061 17.1 0.3 0.018 15.6 0.2 2.0 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO02135.1 - 0.0084 16.4 0.1 0.017 15.4 0.1 1.5 1 0 0 1 1 1 1 AAA domain ADK PF00406.22 ETO02135.1 - 0.013 15.6 0.1 0.24 11.5 0.0 2.2 2 0 0 2 2 2 0 Adenylate kinase MiaE PF06175.11 ETO02135.1 - 0.08 12.5 0.2 0.08 12.5 0.2 1.5 2 0 0 2 2 2 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) AAA_17 PF13207.6 ETO02135.1 - 0.14 12.6 1.1 2.3 8.7 0.2 2.6 2 2 1 3 3 3 0 AAA domain Tubulin_C PF03953.17 ETO02135.1 - 0.17 12.1 0.4 0.37 11.0 0.1 1.6 2 0 0 2 2 2 0 Tubulin C-terminal domain Ras PF00071.22 ETO02136.1 - 1.2e-41 142.0 0.2 1.9e-41 141.4 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO02136.1 - 1.7e-21 76.6 0.1 3.3e-21 75.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO02136.1 - 9.9e-09 34.9 0.4 1.6e-08 34.2 0.4 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO02136.1 - 3e-05 23.6 0.1 3.9e-05 23.3 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain TFIID_NTD2 PF04494.15 ETO02136.1 - 0.16 12.2 1.7 0.84 9.9 0.8 2.1 1 1 1 2 2 2 0 WD40 associated region in TFIID subunit, NTD2 domain FAD_binding_6 PF00970.24 ETO02137.1 - 1.6e-19 70.1 0.0 4.6e-19 68.6 0.0 1.8 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ETO02137.1 - 3e-08 34.3 0.0 7.5e-06 26.6 0.0 2.6 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain RabGAP-TBC PF00566.18 ETO02138.1 - 3.4e-25 89.0 16.9 2.4e-24 86.2 6.7 3.5 2 1 1 3 3 3 3 Rab-GTPase-TBC domain WD40 PF00400.32 ETO02139.1 - 1e-33 114.8 19.4 7.3e-08 33.0 0.3 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO02139.1 - 3.6e-14 52.3 8.7 0.02 13.6 0.2 5.4 2 2 4 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02139.1 - 3.4e-11 43.3 3.2 0.0034 17.7 0.1 5.8 4 1 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Hydrolase_4 PF12146.8 ETO02140.1 - 3.3e-10 39.6 0.0 0.00021 20.6 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETO02140.1 - 2.1e-07 30.7 0.0 1.1e-06 28.3 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETO02140.1 - 3e-06 27.2 0.1 3.6e-05 23.7 0.0 2.2 1 1 0 1 1 1 1 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 ETO02140.1 - 0.00041 20.1 0.0 0.06 13.0 0.0 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold FSH1 PF03959.13 ETO02140.1 - 0.0009 19.0 0.1 0.0026 17.4 0.1 1.8 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 ETO02140.1 - 0.0012 18.8 0.0 0.0019 18.1 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold LIP PF03583.14 ETO02140.1 - 0.0012 18.3 0.1 0.0071 15.7 0.0 1.9 2 0 0 2 2 2 1 Secretory lipase DUF1749 PF08538.10 ETO02140.1 - 0.0026 16.9 0.0 0.0033 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) DLH PF01738.18 ETO02140.1 - 0.0076 15.8 0.0 0.014 15.0 0.0 1.5 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ETO02140.1 - 0.045 13.7 0.0 0.46 10.4 0.0 1.9 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Ser_hydrolase PF06821.13 ETO02140.1 - 0.19 11.6 0.0 0.28 11.0 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase NAD_binding_11 PF14833.6 ETO02142.1 - 3.1e-23 82.3 0.4 1.1e-14 54.7 0.0 3.4 3 0 0 3 3 3 3 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 ETO02142.1 - 1.3e-22 80.7 1.4 1.2e-11 45.0 0.1 2.4 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase Aminotran_3 PF00202.21 ETO02143.1 - 5.5e-110 367.8 0.3 2.4e-108 362.4 0.3 2.0 1 1 0 1 1 1 1 Aminotransferase class-III Aminotran_1_2 PF00155.21 ETO02143.1 - 0.0033 16.7 0.0 0.005 16.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Tox-REase-2 PF15646.6 ETO02143.1 - 0.15 12.3 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 2 Pkinase PF00069.25 ETO02144.1 - 0.00012 21.6 0.0 0.00015 21.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO02144.1 - 0.085 12.1 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO02145.1 - 0.087 11.6 0.2 0.23 10.2 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase RGS PF00615.19 ETO02146.1 - 7.7e-09 35.9 6.1 3.2e-08 33.9 2.8 3.0 2 0 0 2 2 2 1 Regulator of G protein signaling domain Pkinase PF00069.25 ETO02146.1 - 0.00078 18.9 2.6 0.00091 18.7 0.3 2.4 2 0 0 2 2 2 1 Protein kinase domain Succ_DH_flav_C PF02910.20 ETO02146.1 - 0.064 13.2 0.1 0.064 13.2 0.1 2.1 2 0 0 2 2 2 0 Fumarate reductase flavoprotein C-term Guanylin PF02058.15 ETO02146.1 - 0.18 12.3 0.4 1.2 9.7 0.3 2.3 2 0 0 2 2 2 0 Guanylin precursor Methyltransf_12 PF08242.12 ETO02146.1 - 0.2 12.4 2.3 0.82 10.5 0.5 3.1 3 0 0 3 3 3 0 Methyltransferase domain CCDC53 PF10152.9 ETO02146.1 - 2 8.8 6.1 1.2 9.5 0.3 2.4 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex Pkinase PF00069.25 ETO02147.1 - 1.2e-15 57.7 0.4 1.2e-14 54.3 0.0 2.6 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO02147.1 - 0.0022 17.3 0.0 0.0067 15.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase VWD PF00094.25 ETO02148.1 - 0.01 16.1 0.0 0.02 15.2 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type D domain NACHT PF05729.12 ETO02151.1 - 1.4e-07 31.5 0.0 1.7e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO02151.1 - 0.00087 18.5 0.1 0.0012 18.1 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO02151.1 - 0.0037 17.6 0.0 0.007 16.6 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO02151.1 - 0.0053 17.2 0.0 0.0063 16.9 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 ETO02151.1 - 0.0076 15.5 0.0 0.011 15.0 0.0 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) SMC_N PF02463.19 ETO02151.1 - 0.0097 15.4 0.0 0.01 15.3 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain DAP3 PF10236.9 ETO02151.1 - 0.035 13.3 0.0 0.065 12.4 0.0 1.4 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 Torsin PF06309.11 ETO02151.1 - 0.074 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Torsin NACHT PF05729.12 ETO02152.1 - 0.00059 19.8 0.0 0.0016 18.4 0.0 1.8 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO02152.1 - 0.00069 19.9 0.1 0.0037 17.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO02152.1 - 0.0029 18.2 0.9 0.035 14.7 0.0 2.7 2 1 0 2 2 2 1 AAA domain ATP_bind_2 PF03668.15 ETO02152.1 - 0.027 13.8 0.0 0.64 9.3 0.0 2.2 2 0 0 2 2 2 0 P-loop ATPase protein family AAA_30 PF13604.6 ETO02152.1 - 0.035 13.8 0.0 0.057 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO02152.1 - 0.041 14.3 2.7 0.22 11.9 0.1 2.7 1 1 1 2 2 2 0 RNA helicase TsaE PF02367.17 ETO02152.1 - 0.057 13.4 0.0 0.44 10.5 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 ETO02152.1 - 0.057 13.3 0.1 0.16 11.8 0.1 1.7 1 1 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ETO02152.1 - 0.064 13.0 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ETO02152.1 - 0.072 12.8 0.1 0.32 10.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 ETO02152.1 - 0.08 13.4 0.3 0.38 11.3 0.0 2.2 2 1 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 ETO02152.1 - 0.17 12.0 0.0 0.44 10.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain HnRNP_M PF11532.8 ETO02152.1 - 0.18 12.0 0.3 0.58 10.4 0.3 1.8 1 0 0 1 1 1 0 Heterogeneous nuclear ribonucleoprotein M TetR_C_23 PF17931.1 ETO02152.1 - 0.19 11.9 3.3 0.29 11.3 0.2 2.5 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain AAA_14 PF13173.6 ETO02152.1 - 2.1 8.4 7.5 3.8 7.6 0.6 2.9 3 1 0 3 3 3 0 AAA domain MCPsignal PF00015.21 ETO02153.1 - 0.012 15.4 6.5 0.3 10.9 2.0 2.6 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Laminin_II PF06009.12 ETO02153.1 - 0.012 15.6 6.2 0.012 15.6 6.2 2.4 1 1 1 2 2 2 0 Laminin Domain II Exonuc_VII_L PF02601.15 ETO02153.1 - 0.047 13.3 4.0 0.064 12.8 4.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_S46 PF10459.9 ETO02153.1 - 0.092 11.4 12.0 0.12 11.0 12.0 1.1 1 0 0 1 1 1 0 Peptidase S46 DUF948 PF06103.11 ETO02153.1 - 0.11 12.7 8.2 0.41 10.9 0.3 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 ETO02153.1 - 0.14 11.1 6.8 0.19 10.6 6.8 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Pex19 PF04614.12 ETO02153.1 - 0.46 10.2 18.1 2.3 7.9 18.2 1.9 1 1 0 1 1 1 0 Pex19 protein family Prominin PF05478.11 ETO02153.1 - 0.75 7.7 14.9 1.1 7.1 14.6 1.4 1 1 0 1 1 1 0 Prominin Seryl_tRNA_N PF02403.22 ETO02153.1 - 0.84 9.9 28.8 3.6 7.9 11.6 2.8 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain PMC2NT PF08066.12 ETO02153.1 - 0.91 10.3 7.9 0.29 11.9 0.9 2.9 1 1 1 2 2 2 0 PMC2NT (NUC016) domain COG2 PF06148.11 ETO02153.1 - 1.2 9.3 17.3 1.6 8.8 5.2 3.4 1 1 2 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 ALMT PF11744.8 ETO02153.1 - 1.5 7.6 11.6 2.3 7.0 11.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Nup54 PF13874.6 ETO02153.1 - 1.7 8.7 12.6 0.54 10.4 5.5 2.3 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 DUF3782 PF12644.7 ETO02153.1 - 3.9 7.7 8.3 18 5.6 0.1 3.1 3 0 0 3 3 2 0 Protein of unknown function (DUF3782) Mu-like_Pro PF10123.9 ETO02153.1 - 4 6.9 10.1 6.2 6.3 10.1 1.3 1 0 0 1 1 1 0 Mu-like prophage I protein DUF4407 PF14362.6 ETO02153.1 - 4.4 6.6 13.7 6.4 6.0 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Med21 PF11221.8 ETO02153.1 - 4.6 7.5 22.3 0.69 10.2 3.2 2.7 3 0 0 3 3 2 0 Subunit 21 of Mediator complex Hormone_1 PF00103.20 ETO02153.1 - 4.9 6.8 12.5 1.1e+02 2.4 12.5 2.4 1 1 0 1 1 1 0 Somatotropin hormone family DUF883 PF05957.13 ETO02153.1 - 5.9 7.6 7.6 18 6.0 2.2 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) Mnd1 PF03962.15 ETO02155.1 - 0.06 13.6 0.9 0.17 12.2 0.9 1.8 1 0 0 1 1 1 0 Mnd1 HTH domain CAP_GLY PF01302.25 ETO02157.1 - 5.6e-06 26.3 0.1 1e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain RNase_H PF00075.24 ETO02158.1 - 6.2e-24 84.8 0.0 8.7e-24 84.3 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETO02158.1 - 1.6e-08 34.4 0.0 2.4e-08 33.8 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase-like Peptidase_C14 PF00656.22 ETO02159.1 - 8.5e-06 25.9 0.1 1.4e-05 25.2 0.1 1.3 1 1 0 1 1 1 1 Caspase domain SAM_2 PF07647.17 ETO02160.1 - 0.0083 16.2 0.2 23 5.2 0.0 3.7 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO02160.1 - 0.03 14.7 0.4 25 5.4 0.0 3.6 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) KilA-N PF04383.13 ETO02160.1 - 0.49 10.3 5.4 5.8 6.8 0.0 3.0 3 1 0 3 3 3 0 KilA-N domain Cauli_AT PF03233.13 ETO02160.1 - 2.4 8.1 10.0 0.53 10.2 4.9 2.5 1 1 0 2 2 2 0 Aphid transmission protein BMP2K_C PF15282.6 ETO02161.1 - 0.044 13.6 0.6 0.05 13.5 0.6 1.1 1 0 0 1 1 1 0 BMP-2-inducible protein kinase C-terminus DUF4653 PF15546.6 ETO02164.1 - 0.094 12.3 1.0 0.14 11.8 1.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4653) Kelch_2 PF07646.15 ETO02165.1 - 0.027 14.4 0.1 2.5 8.2 0.0 3.4 4 0 0 4 4 4 0 Kelch motif ATP-synt_E_2 PF08112.11 ETO02166.1 - 0.045 14.0 4.3 0.21 11.9 0.3 3.2 2 0 0 2 2 2 0 ATP synthase epsilon subunit TBCA PF02970.16 ETO02166.1 - 0.52 10.7 10.7 0.39 11.1 1.3 3.4 3 1 0 3 3 3 0 Tubulin binding cofactor A PI_PP_I PF18363.1 ETO02166.1 - 3.2 8.0 6.5 0.32 11.2 0.5 2.4 3 1 1 4 4 4 0 Phosphoinositide phosphatase insertion domain HEAT PF02985.22 ETO02168.1 - 2.5e-14 52.1 0.0 0.015 15.5 0.0 6.6 7 0 0 7 7 7 3 HEAT repeat HEAT_2 PF13646.6 ETO02168.1 - 5.5e-09 36.3 0.0 0.00013 22.3 0.0 3.3 3 1 1 4 4 4 3 HEAT repeats RTP1_C1 PF10363.9 ETO02168.1 - 9.9e-09 35.4 0.0 0.036 14.3 0.0 4.5 3 2 1 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ETO02168.1 - 5.6e-06 26.7 0.0 5.5 7.6 0.0 5.6 6 1 1 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 ETO02168.1 - 5.4e-05 23.3 21.8 0.00078 19.5 0.1 6.0 3 2 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETO02168.1 - 0.00014 21.7 13.0 0.055 13.3 0.1 4.8 4 1 1 6 6 6 3 TATA-binding protein interacting (TIP20) G6PD_N PF00479.22 ETO02168.1 - 0.81 10.3 3.4 1.4 9.5 0.1 2.8 2 1 1 3 3 3 0 Glucose-6-phosphate dehydrogenase, NAD binding domain WD40 PF00400.32 ETO02169.1 - 2e-14 53.7 13.3 1.4e-07 32.0 1.6 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02169.1 - 1.6e-05 23.8 1.1 0.024 13.3 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02169.1 - 0.02 15.2 0.1 0.1 12.9 0.0 2.1 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain GreA_GreB_N PF03449.15 ETO02173.1 - 0.0038 17.4 0.6 0.0074 16.4 0.0 1.7 2 0 0 2 2 2 1 Transcription elongation factor, N-terminal DUF956 PF06115.11 ETO02173.1 - 0.075 12.7 0.4 0.075 12.7 0.4 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF956) ATG16 PF08614.11 ETO02175.1 - 0.0034 17.6 41.7 0.011 16.0 23.2 2.5 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) Phage_GP20 PF06810.11 ETO02175.1 - 0.014 15.2 7.1 0.014 15.2 7.1 5.0 1 1 4 5 5 5 0 Phage minor structural protein GP20 KASH_CCD PF14662.6 ETO02175.1 - 0.022 14.6 50.7 0.19 11.5 33.7 2.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH Mod_r PF07200.13 ETO02175.1 - 0.027 14.6 15.1 0.027 14.6 15.1 3.8 1 1 3 4 4 4 0 Modifier of rudimentary (Mod(r)) protein ERM PF00769.19 ETO02175.1 - 0.036 13.9 46.2 0.26 11.1 46.3 1.9 1 1 0 1 1 1 0 Ezrin/radixin/moesin family bZIP_1 PF00170.21 ETO02175.1 - 0.051 13.7 54.8 0.14 12.3 1.0 6.3 2 1 3 6 6 6 0 bZIP transcription factor CALCOCO1 PF07888.11 ETO02175.1 - 0.056 12.3 45.1 0.15 10.9 45.1 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like HAP1_N PF04849.13 ETO02175.1 - 0.063 12.5 44.0 0.017 14.4 38.8 2.2 1 1 1 2 2 2 0 HAP1 N-terminal conserved region CENP-F_leu_zip PF10473.9 ETO02175.1 - 0.18 11.8 47.5 0.33 11.0 24.8 3.1 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 ETO02175.1 - 0.2 11.8 51.3 0.45 10.6 19.3 3.5 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 ETO02175.1 - 0.53 10.4 56.9 9.5 6.3 25.8 3.5 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.7 ETO02175.1 - 0.63 10.2 53.6 1.3 9.2 17.4 2.9 1 1 2 3 3 3 0 Tropomyosin like ZapB PF06005.12 ETO02175.1 - 1.5 9.3 59.6 0.46 11.0 7.3 4.8 1 1 3 4 4 4 0 Cell division protein ZapB GAS PF13851.6 ETO02175.1 - 2.4 7.5 60.8 0.21 10.9 20.3 3.1 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Atg14 PF10186.9 ETO02175.1 - 3.6 6.6 47.8 4.2 6.4 20.9 2.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 HrpB7 PF09486.10 ETO02175.1 - 4.5 7.6 15.4 6.5 7.1 1.2 3.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) BRE1 PF08647.11 ETO02175.1 - 4.6 7.4 58.6 1.2 9.2 28.2 3.3 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase Filament PF00038.21 ETO02175.1 - 4.8 6.7 47.2 0.1 12.2 13.9 3.2 1 1 3 4 4 4 0 Intermediate filament protein DUF3584 PF12128.8 ETO02175.1 - 5.4 4.4 42.0 8.2 3.8 42.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) APG6_N PF17675.1 ETO02175.1 - 6.8 7.2 53.2 1.2 9.6 12.0 3.3 1 1 2 3 3 2 0 Apg6 coiled-coil region HMMR_C PF15908.5 ETO02175.1 - 7 6.9 40.4 2.2 8.5 12.9 3.9 1 1 3 4 4 4 0 Hyaluronan mediated motility receptor C-terminal Fez1 PF06818.15 ETO02175.1 - 8.1 6.9 46.5 0.69 10.3 17.2 2.1 1 1 1 2 2 2 0 Fez1 PRKG1_interact PF15898.5 ETO02175.1 - 8.2 7.4 51.8 0.35 11.8 13.0 3.9 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain AAA-ATPase_like PF09820.9 ETO02177.1 - 0.0092 15.4 3.3 0.012 15.1 3.3 1.1 1 0 0 1 1 1 1 Predicted AAA-ATPase Connexin PF00029.19 ETO02178.1 - 0.94 9.2 4.0 1.3 8.7 4.0 1.3 1 0 0 1 1 1 0 Connexin SDA1 PF05285.12 ETO02178.1 - 4.6 6.6 21.5 4.9 6.5 21.5 1.0 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO02178.1 - 4.9 5.2 19.2 5.6 5.0 19.2 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO02178.1 - 6 5.0 14.9 6.3 5.0 14.9 1.0 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO02179.1 - 0.034 15.0 0.0 0.11 13.4 0.0 1.9 1 0 0 1 1 1 0 WD domain, G-beta repeat PRMT5_C PF17286.2 ETO02179.1 - 0.091 12.6 1.9 0.12 12.2 1.9 1.5 1 1 0 1 1 1 0 PRMT5 oligomerisation domain TMEMspv1-c74-12 PF11044.8 ETO02179.1 - 0.94 9.5 0.1 0.94 9.5 0.1 3.4 3 0 0 3 3 3 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein zf-TRAF PF02176.18 ETO02180.1 - 3.7e-06 27.5 3.7 3.7e-06 27.5 3.7 2.5 2 1 0 2 2 2 1 TRAF-type zinc finger Zn_ribbon_2 PF12674.7 ETO02181.1 - 1.3 9.8 4.0 2.8 8.7 0.7 2.6 3 0 0 3 3 3 0 Putative zinc ribbon domain Hepar_II_III_N PF16889.5 ETO02182.1 - 0.0036 16.6 1.1 0.0053 16.1 0.9 1.4 1 1 0 1 1 1 1 Heparinase II/III N-terminus TetR_C_13 PF16925.5 ETO02182.1 - 0.076 12.9 0.8 7.8 6.5 0.1 2.9 2 1 1 3 3 3 0 Tetracyclin repressor-like, C-terminal domain Nbl1_Borealin_N PF10444.9 ETO02182.1 - 0.26 11.0 4.4 0.84 9.3 0.7 3.0 3 0 0 3 3 3 0 Nbl1 / Borealin N terminal TBCC_N PF16752.5 ETO02182.1 - 0.48 10.9 8.1 0.18 12.2 3.8 2.5 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Ank_2 PF12796.7 ETO02183.1 - 0.00023 21.7 0.7 0.0065 17.0 0.1 2.4 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) ELYS PF13934.6 ETO02183.1 - 0.0022 18.0 0.1 0.0028 17.7 0.1 1.1 1 0 0 1 1 1 1 Nuclear pore complex assembly Ank_3 PF13606.6 ETO02183.1 - 0.032 14.8 0.5 4.5 8.2 0.0 3.8 5 0 0 5 5 5 0 Ankyrin repeat Ank_4 PF13637.6 ETO02183.1 - 0.063 13.9 0.1 1.8 9.2 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeats (many copies) WD40 PF00400.32 ETO02184.1 - 3.5e-56 185.9 21.4 3.6e-12 46.6 0.2 5.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02184.1 - 8.7e-25 86.9 0.2 2.3e-05 24.6 0.0 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02184.1 - 8.3e-13 48.3 0.2 0.00029 20.3 0.0 3.4 1 1 2 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO02184.1 - 6.6e-10 38.1 1.4 0.00027 19.6 0.2 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ETO02184.1 - 1.4e-09 37.4 1.1 0.18 10.7 0.0 4.9 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO02184.1 - 1.8e-08 33.5 2.5 0.22 10.1 0.1 4.3 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO02184.1 - 1e-06 28.5 0.2 0.063 12.9 0.0 3.0 1 1 2 3 3 3 3 PQQ-like domain Frtz PF11768.8 ETO02184.1 - 0.00019 19.9 0.0 0.53 8.5 0.0 2.9 1 1 3 4 4 4 4 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETO02184.1 - 0.0043 17.2 6.7 5.2 7.2 0.1 4.4 1 1 4 5 5 5 1 Family of unknown function (DUF5570) Invas_SpaK PF03519.14 ETO02184.1 - 0.0054 16.8 1.4 0.62 10.2 0.0 3.1 2 2 1 3 3 3 1 Invasion protein B family PD40 PF07676.12 ETO02184.1 - 0.0061 16.5 0.8 9.2 6.3 0.0 3.7 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Rpn3_C PF08375.11 ETO02184.1 - 0.0075 16.7 0.0 10 6.7 0.0 4.3 3 2 2 5 5 5 0 Proteasome regulatory subunit C-terminal VID27 PF08553.10 ETO02184.1 - 0.0088 15.1 0.0 0.16 11.0 0.0 2.1 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain BLUF PF04940.12 ETO02184.1 - 0.012 15.7 0.0 27 5.0 0.0 3.9 3 2 1 4 4 4 0 Sensors of blue-light using FAD Ret2_MD PF18528.1 ETO02184.1 - 0.019 15.3 0.1 58 4.2 0.0 4.0 1 1 4 5 5 5 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Big_7 PF17957.1 ETO02184.1 - 0.025 15.3 1.7 6.2 7.7 0.0 3.7 3 1 1 4 4 4 0 Bacterial Ig domain DPPIV_N PF00930.21 ETO02184.1 - 0.034 12.9 1.5 23 3.6 0.0 3.8 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO02184.1 - 0.041 13.8 0.0 8.2 6.5 0.0 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat NYD-SP28_assoc PF14775.6 ETO02184.1 - 0.042 13.9 0.2 5.9 7.1 0.0 3.8 5 0 0 5 5 5 0 Sperm tail C-terminal domain ASCH PF04266.14 ETO02184.1 - 0.044 14.4 0.0 17 6.0 0.0 3.6 4 0 0 4 4 4 0 ASCH domain TPR_12 PF13424.6 ETO02185.1 - 2.4e-27 95.0 1.8 2.4e-12 46.9 0.3 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02185.1 - 1.3e-17 62.8 19.2 2.6e-06 27.0 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02185.1 - 8.6e-17 59.9 3.7 9.9e-06 25.2 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02185.1 - 1.6e-15 56.4 0.3 2.9e-06 27.0 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02185.1 - 6.5e-14 50.8 12.8 0.00055 19.8 0.6 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02185.1 - 3.9e-13 48.5 22.8 6.1e-05 22.9 2.0 5.3 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02185.1 - 2.3e-06 27.8 0.4 1.3 9.8 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02185.1 - 4e-05 24.2 0.0 1.1 10.0 0.0 3.7 3 1 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO02185.1 - 0.002 18.3 7.5 0.25 11.6 4.9 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETO02185.1 - 0.002 17.8 15.3 0.048 13.3 0.1 4.3 4 0 0 4 4 4 2 TPR repeat DUF5113 PF17140.4 ETO02185.1 - 0.0043 16.9 6.2 0.18 11.6 0.2 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO02185.1 - 0.0055 17.4 0.0 42 5.3 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02185.1 - 0.0082 16.5 1.5 3.8 8.1 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat SPO22 PF08631.10 ETO02185.1 - 0.015 14.8 1.7 0.33 10.4 0.2 2.7 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like DUF4752 PF15944.5 ETO02185.1 - 0.023 14.7 0.0 0.057 13.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) TPR_MalT PF17874.1 ETO02185.1 - 0.046 13.1 0.0 0.069 12.5 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region Lipase_GDSL_3 PF14606.6 ETO02185.1 - 0.085 13.0 4.6 0.78 9.8 0.0 2.7 3 0 0 3 3 3 0 GDSL-like Lipase/Acylhydrolase family Mss4 PF04421.13 ETO02185.1 - 0.15 12.2 2.5 0.46 10.7 0.5 2.4 1 1 1 2 2 2 0 Mss4 protein DUF3775 PF12616.8 ETO02185.1 - 0.17 11.9 0.0 0.56 10.3 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3775) Phage_Treg PF04761.12 ETO02185.1 - 2.7 8.2 6.4 2.9 8.0 0.2 3.6 3 1 1 4 4 3 0 Lactococcus bacteriophage putative transcription regulator WD40 PF00400.32 ETO02186.1 - 2.2e-05 25.1 2.0 9.4e-05 23.1 1.2 2.3 2 2 0 2 2 2 1 WD domain, G-beta repeat DUF600 PF04634.12 ETO02187.1 - 0.0037 17.3 5.4 0.031 14.3 0.1 2.9 2 1 0 2 2 2 1 Protein of unknown function, DUF600 DHquinase_II PF01220.19 ETO02187.1 - 0.04 13.6 0.0 0.067 12.9 0.0 1.3 1 0 0 1 1 1 0 Dehydroquinase class II PUB PF09409.10 ETO02190.1 - 0.013 15.4 0.5 0.13 12.2 0.5 2.1 1 1 0 1 1 1 0 PUB domain UPF0122 PF04297.14 ETO02190.1 - 0.038 14.2 2.7 0.89 9.8 0.5 2.1 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like TPR_12 PF13424.6 ETO02191.1 - 2.1e-16 60.0 0.0 2e-08 34.4 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02191.1 - 1.9e-12 46.4 1.9 2.9e-05 23.7 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02191.1 - 1.6e-08 34.0 0.3 0.0025 17.8 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02191.1 - 1.3e-07 31.2 0.1 0.031 14.1 0.0 3.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02191.1 - 2.9e-07 30.1 0.0 0.00033 20.5 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02191.1 - 3.6e-07 29.9 4.7 0.0039 17.3 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO02191.1 - 0.065 13.3 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 ETO02191.1 - 0.078 12.7 0.5 11 5.9 0.1 2.8 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.6 ETO02191.1 - 0.083 13.6 0.1 14 6.5 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02191.1 - 0.24 11.9 4.9 13 6.4 0.0 4.1 4 1 0 4 4 4 0 Tetratricopeptide repeat BOF PF04076.13 ETO02192.1 - 0.022 14.8 0.2 0.038 14.1 0.2 1.4 1 0 0 1 1 1 0 Bacterial OB fold (BOF) protein ISP3_C PF18045.1 ETO02192.1 - 0.086 12.7 1.4 3 7.7 0.1 2.5 2 1 1 3 3 3 0 ISP3 C-terminal DUF4297 PF14130.6 ETO02192.1 - 0.1 12.7 3.9 0.14 12.2 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4297) TPR_12 PF13424.6 ETO02193.1 - 1.9e-38 130.6 8.1 5.8e-11 42.5 0.1 4.1 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02193.1 - 1.3e-22 78.9 1.5 1.7e-06 27.7 0.0 5.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02193.1 - 6.1e-19 67.0 12.3 2.8e-07 30.1 0.3 4.9 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02193.1 - 3.3e-16 58.0 2.1 0.0045 16.9 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02193.1 - 2.6e-13 49.0 5.5 0.1 12.9 0.2 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02193.1 - 4.3e-12 45.2 2.7 0.036 14.2 0.1 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO02193.1 - 2.7e-06 27.0 2.2 0.018 14.4 0.3 2.2 1 1 1 2 2 2 2 MalT-like TPR region MIT PF04212.18 ETO02193.1 - 0.00013 21.9 2.7 0.24 11.5 0.0 4.1 4 0 0 4 4 3 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO02193.1 - 0.00031 20.4 5.9 2.2 8.0 0.4 5.4 4 1 1 5 5 5 1 TPR repeat TPR_17 PF13431.6 ETO02193.1 - 0.00034 20.8 0.4 0.2 12.1 0.1 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02193.1 - 0.0029 18.1 0.8 27 5.7 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02193.1 - 0.015 15.9 0.0 44 4.8 0.0 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02193.1 - 0.035 14.9 0.0 57 4.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4404 PF14357.6 ETO02193.1 - 0.051 14.2 0.6 0.11 13.1 0.0 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4404) Bactofilin PF04519.13 ETO02193.1 - 0.081 13.2 0.1 0.41 11.0 0.0 2.2 2 0 0 2 2 2 0 Polymer-forming cytoskeletal DUF5113 PF17140.4 ETO02193.1 - 0.085 12.7 3.1 1.4 8.8 0.4 3.3 2 2 0 3 3 3 0 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO02193.1 - 0.21 11.6 8.4 6.7 6.8 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat Laps PF10169.9 ETO02193.1 - 3.4 8.3 7.6 0.5 11.0 0.4 2.6 1 1 1 2 2 2 0 Learning-associated protein WD40 PF00400.32 ETO02194.1 - 2.4e-39 132.6 19.4 5.6e-08 33.3 0.4 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02194.1 - 5.5e-13 49.0 0.4 0.034 14.5 0.0 5.3 5 1 0 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02194.1 - 1e-08 34.3 4.7 0.16 10.6 0.0 5.2 2 1 0 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO02194.1 - 0.0017 17.7 0.3 2.5 7.4 0.0 4.1 2 2 1 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO02195.1 - 2.2e-30 104.2 15.6 9.8e-10 38.9 0.4 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02195.1 - 2.6e-10 40.5 0.0 0.00015 22.0 0.0 3.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02195.1 - 0.0062 15.9 0.1 0.031 13.6 0.1 2.0 1 1 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETO02195.1 - 0.013 14.5 0.1 1.7 7.5 0.0 2.7 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO02195.1 - 0.021 14.8 0.6 8.6 6.4 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO02195.1 - 0.032 12.9 0.0 0.19 10.4 0.0 2.1 2 1 1 3 3 3 0 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO02196.1 - 5e-06 27.1 2.5 5e-06 27.1 2.5 3.2 3 1 1 4 4 4 1 TRAF-type zinc finger RGS PF00615.19 ETO02196.1 - 0.014 15.6 1.6 0.014 15.6 1.6 2.5 2 1 1 3 3 3 0 Regulator of G protein signaling domain zf-C3HC4_3 PF13920.6 ETO02196.1 - 0.42 10.5 4.5 2.6 8.0 4.5 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Acyl-CoA_dh_C PF12806.7 ETO02198.1 - 0.11 12.6 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 Acetyl-CoA dehydrogenase C-terminal like zf-TRAF PF02176.18 ETO02199.1 - 3.9e-06 27.5 7.0 3.9e-06 27.5 7.0 2.2 2 1 0 2 2 2 1 TRAF-type zinc finger Glypican PF01153.19 ETO02201.1 - 0.057 12.3 0.0 0.061 12.2 0.0 1.0 1 0 0 1 1 1 0 Glypican PhoQ_Sensor PF08918.10 ETO02203.1 - 0.045 13.6 1.3 0.083 12.7 0.3 1.9 1 1 1 2 2 2 0 PhoQ Sensor WD40 PF00400.32 ETO02204.1 - 2.8e-05 24.8 0.1 0.00083 20.1 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Topoisom_I_N PF02919.15 ETO02204.1 - 6.4 6.2 11.1 5.2 6.5 8.7 1.8 1 1 1 2 2 2 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Ank_2 PF12796.7 ETO02205.1 - 4.4e-07 30.4 0.2 0.0012 19.4 0.2 2.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO02205.1 - 0.002 18.4 0.0 20 6.1 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_4 PF13637.6 ETO02205.1 - 0.0035 17.9 0.1 1.2 9.8 0.0 3.3 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO02205.1 - 0.0057 16.9 0.0 0.075 13.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Urm1 PF09138.11 ETO02205.1 - 0.0096 16.3 1.6 1.1 9.6 0.2 2.9 2 1 0 2 2 2 1 Urm1 (Ubiquitin related modifier) Ank PF00023.30 ETO02205.1 - 0.013 16.0 0.0 0.73 10.4 0.0 2.8 3 0 0 3 3 3 0 Ankyrin repeat MRP-S33 PF08293.11 ETO02206.1 - 0.022 15.0 0.6 0.034 14.4 0.6 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 DUF1746 PF08508.10 ETO02206.1 - 0.074 13.4 0.1 0.084 13.2 0.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) Sigma70_ner PF04546.13 ETO02207.1 - 0.0021 18.0 1.8 0.0021 18.0 1.8 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region GOLD_2 PF13897.6 ETO02207.1 - 0.034 14.7 1.5 0.035 14.6 1.5 1.1 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF4471 PF14740.6 ETO02207.1 - 0.042 13.1 1.7 0.042 13.1 1.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) FAM176 PF14851.6 ETO02207.1 - 0.051 13.2 6.8 0.06 13.0 6.8 1.1 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ETO02207.1 - 0.06 13.7 5.7 0.07 13.5 5.7 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Phage_Gp23 PF10669.9 ETO02207.1 - 0.078 13.3 5.0 0.11 12.9 5.0 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Kelch_6 PF13964.6 ETO02207.1 - 0.095 13.0 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Kelch motif CPSF100_C PF13299.6 ETO02207.1 - 0.15 12.2 3.3 0.18 12.0 3.3 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal D123 PF07065.14 ETO02207.1 - 0.52 9.4 6.2 0.66 9.1 6.2 1.2 1 0 0 1 1 1 0 D123 Pox_Ag35 PF03286.14 ETO02207.1 - 0.53 10.0 8.0 0.61 9.9 8.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO02207.1 - 0.66 8.0 11.8 0.68 8.0 11.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO02207.1 - 0.75 7.9 11.0 0.79 7.9 11.0 1.0 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 ETO02207.1 - 1.4 8.1 6.0 1.6 7.9 6.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sporozoite_P67 PF05642.11 ETO02207.1 - 2.4 6.2 7.9 2.4 6.2 7.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CDC45 PF02724.14 ETO02207.1 - 3.2 6.0 9.9 3.2 5.9 9.9 1.0 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO02207.1 - 3.3 6.1 7.5 3.4 6.1 7.5 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 S-antigen PF05756.11 ETO02207.1 - 8.1 6.9 9.7 12 6.3 9.7 1.4 1 0 0 1 1 1 0 S-antigen protein DUF2457 PF10446.9 ETO02207.1 - 8.7 5.4 14.9 9.6 5.2 14.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) WD40 PF00400.32 ETO02208.1 - 2.3e-27 94.7 5.3 6.7e-08 33.1 0.3 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02208.1 - 5e-12 46.0 0.2 0.00018 21.7 0.2 3.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ETO02208.1 - 2.1e-05 22.8 0.0 4.8e-05 21.6 0.0 1.7 1 1 1 2 2 2 1 IKI3 family Nup160 PF11715.8 ETO02208.1 - 2.2e-05 23.3 0.4 0.016 13.8 0.2 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO02208.1 - 0.00031 20.7 0.7 0.0038 17.1 0.5 2.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO02208.1 - 0.00065 18.8 0.0 3.8 6.4 0.0 3.0 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO02208.1 - 0.0016 17.8 0.7 0.047 13.0 0.1 2.6 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Bac_transf PF02397.16 ETO02208.1 - 0.14 11.8 1.4 0.2 11.2 1.4 1.2 1 0 0 1 1 1 0 Bacterial sugar transferase YozE_SAM_like PF06855.12 ETO02211.1 - 0.018 15.2 1.4 0.029 14.5 0.2 2.0 2 0 0 2 2 2 0 YozE SAM-like fold HEAT_2 PF13646.6 ETO02211.1 - 0.045 14.1 0.0 0.26 11.7 0.0 1.9 1 1 1 2 2 2 0 HEAT repeats Peptidase_M9_N PF08453.10 ETO02211.1 - 0.049 13.3 1.2 0.063 13.0 1.2 1.1 1 0 0 1 1 1 0 Peptidase family M9 N-terminal RTP1_C1 PF10363.9 ETO02211.1 - 0.084 13.1 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 MapZ_EC1 PF18041.1 ETO02211.1 - 0.11 12.8 1.1 0.26 11.5 1.0 1.8 1 1 0 1 1 1 0 MapZ extracellular domain 1 HEAT_EZ PF13513.6 ETO02211.1 - 0.22 12.1 0.0 1.4 9.5 0.0 2.1 2 0 0 2 2 2 0 HEAT-like repeat HEAT_2 PF13646.6 ETO02212.1 - 1.8e-16 60.3 0.0 3.1e-06 27.5 0.0 4.2 2 2 3 5 5 5 4 HEAT repeats HEAT PF02985.22 ETO02212.1 - 6.9e-14 50.8 0.0 0.063 13.6 0.0 5.3 5 0 0 5 5 4 3 HEAT repeat Cnd1 PF12717.7 ETO02212.1 - 1.9e-08 34.5 7.2 0.0012 18.9 0.5 3.3 1 1 3 4 4 4 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO02212.1 - 4.7e-07 30.2 0.0 1.3 9.6 0.0 5.1 3 1 2 5 5 5 2 HEAT-like repeat CLASP_N PF12348.8 ETO02212.1 - 3.8e-05 23.4 0.7 0.094 12.3 0.0 2.8 3 0 0 3 3 3 2 CLASP N terminal RTP1_C1 PF10363.9 ETO02212.1 - 4.2e-05 23.7 1.3 0.88 9.8 0.5 4.0 2 2 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO02212.1 - 0.00042 20.9 7.8 0.33 11.6 0.1 5.3 4 2 3 7 7 7 1 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO02212.1 - 0.0012 18.7 6.8 0.92 9.3 0.1 4.3 2 2 0 3 3 3 1 TATA-binding protein interacting (TIP20) HEAT_PBS PF03130.16 ETO02212.1 - 0.0085 16.7 0.0 10 7.2 0.0 4.5 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat DUF3810 PF12725.7 ETO02212.1 - 0.013 14.9 0.7 0.097 12.0 0.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) NLE PF08154.12 ETO02212.1 - 0.021 15.4 5.6 13 6.3 0.0 4.6 1 1 3 4 4 4 0 NLE (NUC135) domain FCH PF00611.23 ETO02212.1 - 0.077 13.3 3.1 1.4 9.3 0.2 3.5 3 2 0 3 3 3 0 Fes/CIP4, and EFC/F-BAR homology domain Syntaphilin PF15290.6 ETO02212.1 - 0.094 12.3 2.2 6.9 6.2 0.3 2.4 1 1 1 2 2 2 0 Golgi-localised syntaxin-1-binding clamp HBB PF06777.11 ETO02212.1 - 0.1 12.3 3.2 15 5.2 0.1 3.8 3 2 2 5 5 5 0 Helical and beta-bridge domain DUF5105 PF17118.5 ETO02212.1 - 0.27 11.0 6.0 13 5.6 0.3 4.3 2 2 3 5 5 5 0 Domain of unknown function (DUF5105) Spore_III_AB PF09548.10 ETO02212.1 - 0.34 11.0 4.6 0.7 10.0 1.4 3.1 2 1 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) DUF3349 PF11829.8 ETO02212.1 - 0.43 11.4 2.8 1.4e+02 3.4 0.1 4.4 2 1 3 5 5 5 0 Protein of unknown function (DUF3349) GatB_Yqey PF02637.18 ETO02212.1 - 1.3 8.9 5.9 3.3 7.6 3.7 2.5 1 1 1 2 2 2 0 GatB domain MSP7_C PF12948.7 ETO02212.1 - 1.5 9.5 9.8 12 6.5 0.3 4.1 1 1 1 4 4 4 0 MSP7-like protein C-terminal domain AvrM-A PF18241.1 ETO02212.1 - 2.9 8.3 6.1 18 5.7 0.4 3.2 2 1 1 3 3 3 0 Flax-rust effector AvrM-A DUF4795 PF16043.5 ETO02212.1 - 5 6.7 9.2 0.59 9.7 1.6 2.5 2 2 0 2 2 2 0 Domain of unknown function (DUF4795) MEF2_binding PF09047.10 ETO02213.1 - 0.085 12.7 1.0 0.16 11.8 0.2 1.8 2 0 0 2 2 2 0 MEF2 binding TssO PF17561.2 ETO02217.1 - 0.013 15.6 9.7 0.017 15.2 9.7 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssO YMF19 PF02326.15 ETO02217.1 - 0.014 16.2 5.5 0.02 15.7 5.5 1.2 1 0 0 1 1 1 0 Plant ATP synthase F0 Ribosomal_L6e PF01159.19 ETO02217.1 - 0.019 15.5 4.5 0.029 14.9 4.5 1.3 1 0 0 1 1 1 0 Ribosomal protein L6e Saf_2TM PF18303.1 ETO02217.1 - 0.036 13.7 0.1 0.053 13.1 0.1 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Neur_chan_memb PF02932.16 ETO02217.1 - 0.072 13.1 0.4 0.08 13.0 0.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SCIMP PF15050.6 ETO02217.1 - 0.12 12.8 1.1 0.18 12.3 0.3 1.5 1 1 0 1 1 1 0 SCIMP protein O_anti_polymase PF01901.16 ETO02217.1 - 0.2 10.9 1.8 0.22 10.8 1.8 1.1 1 0 0 1 1 1 0 Putative O-antigen polymerase ETRAMP PF09716.10 ETO02217.1 - 0.64 10.1 11.4 1.1 9.3 11.4 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3784 PF12650.7 ETO02217.1 - 4.1 7.7 9.9 18 5.6 9.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3784) Rpn3_C PF08375.11 ETO02218.1 - 0.56 10.7 3.5 3.2 8.2 0.0 2.2 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal bHLH-MYC_N PF14215.6 ETO02219.1 - 0.063 13.6 0.3 0.074 13.3 0.3 1.1 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal zf-RING-like PF08746.11 ETO02219.1 - 0.15 12.4 4.9 1.2 9.5 2.9 2.6 1 1 1 2 2 2 0 RING-like domain zf-C3HC4_2 PF13923.6 ETO02219.1 - 1.4 8.8 10.1 23 4.9 6.3 3.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO02219.1 - 2.3 8.7 8.4 5.3 7.4 4.4 3.1 2 1 1 3 3 3 0 Ring finger domain TPR_12 PF13424.6 ETO02220.1 - 3e-28 97.9 6.6 6.8e-15 55.1 0.3 3.5 1 1 4 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02220.1 - 2.7e-13 49.3 4.1 7.7e-05 22.4 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02220.1 - 9e-11 41.1 16.1 0.00047 19.9 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02220.1 - 4e-10 39.0 2.6 0.0014 18.6 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02220.1 - 9.9e-07 28.4 15.4 0.016 15.3 0.1 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02220.1 - 5.9e-05 23.0 14.7 0.08 13.2 0.1 4.1 4 0 0 4 4 3 3 Tetratricopeptide repeat MIT PF04212.18 ETO02220.1 - 0.00019 21.4 0.2 0.082 13.0 0.1 2.7 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO02220.1 - 0.073 13.5 1.3 26 5.5 0.1 3.2 2 0 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 ETO02220.1 - 0.079 12.4 4.4 0.67 9.3 0.1 2.9 4 0 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO02220.1 - 0.28 10.9 6.9 1.5 8.5 0.0 3.4 3 1 1 4 4 4 0 TPR repeat CD45 PF12567.8 ETO02220.1 - 3.3 7.8 8.5 1.6 8.7 0.5 3.7 3 0 0 3 3 3 0 Leukocyte receptor CD45 U-box PF04564.15 ETO02222.1 - 2e-14 53.5 0.0 4.4e-14 52.4 0.0 1.6 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO02222.1 - 0.042 14.0 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein MotCF PF09158.10 ETO02222.1 - 0.12 12.5 0.9 6 7.0 0.1 2.2 2 0 0 2 2 2 0 Bacteriophage T4 MotA, C-terminal SAM_2 PF07647.17 ETO02223.1 - 0.0017 18.4 0.5 0.0047 17.0 0.5 1.8 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) PPIP5K2_N PF18086.1 ETO02223.1 - 0.027 14.6 0.4 5.1 7.3 0.1 2.4 2 0 0 2 2 2 0 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain SNCAIP_SNCA_bd PF16700.5 ETO02223.1 - 0.053 13.2 0.1 0.14 11.9 0.1 1.7 1 0 0 1 1 1 0 Synphilin-1 alpha-Synuclein-binding domain WD40 PF00400.32 ETO02225.1 - 3.2e-44 148.0 7.5 3.9e-09 37.0 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02225.1 - 4.1e-19 68.7 2.9 0.013 15.8 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO02225.1 - 8.6e-12 44.6 0.4 0.012 14.6 0.0 4.4 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO02225.1 - 8.1e-07 28.1 3.5 0.18 10.4 0.1 4.5 2 2 1 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO02225.1 - 4.8e-06 26.4 2.6 38 4.4 0.1 6.3 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO02225.1 - 0.00091 18.4 0.3 0.0054 15.8 0.3 2.2 1 1 0 1 1 1 1 Coatomer WD associated region WD40_like PF17005.5 ETO02225.1 - 0.0052 16.2 0.2 0.59 9.4 0.0 2.8 1 1 2 3 3 3 1 WD40-like domain Resistin PF06954.11 ETO02225.1 - 0.0074 16.8 0.7 14 6.3 0.0 3.7 2 2 2 4 4 4 1 Resistin Cytochrom_D1 PF02239.16 ETO02225.1 - 0.014 13.9 0.1 0.67 8.4 0.0 2.3 1 1 1 2 2 2 0 Cytochrome D1 heme domain DUF4279 PF14106.6 ETO02226.1 - 0.025 14.8 0.8 0.036 14.3 0.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4279) SMC_ScpB PF04079.16 ETO02226.1 - 0.14 11.8 0.5 0.14 11.7 0.5 1.0 1 0 0 1 1 1 0 Segregation and condensation complex subunit ScpB CdiI PF07262.11 ETO02226.1 - 0.53 10.1 13.0 0.38 10.5 11.9 1.3 1 1 0 1 1 1 0 CDI immunity protein TMPIT PF07851.13 ETO02226.1 - 7.4 5.7 9.1 8.9 5.4 9.1 1.0 1 0 0 1 1 1 0 TMPIT-like protein Mit_KHE1 PF10173.9 ETO02226.1 - 7.8 6.5 9.1 8.6 6.4 9.1 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF960 PF06124.11 ETO02230.1 - 0.00071 20.2 0.6 0.0014 19.2 0.6 1.6 1 1 0 1 1 1 1 Staphylococcal protein of unknown function (DUF960) NicO PF03824.16 ETO02234.1 - 0.57 9.5 1.9 1.3 8.3 1.9 1.5 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF2052 PF09747.9 ETO02234.1 - 2.7 8.1 13.8 3.1 7.9 4.2 2.6 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Zip PF02535.22 ETO02234.1 - 4 6.5 10.5 0.25 10.5 4.5 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter PNPase PF03726.14 ETO02238.1 - 0.0052 17.2 0.1 0.007 16.8 0.1 1.2 1 0 0 1 1 1 1 Polyribonucleotide nucleotidyltransferase, RNA binding domain OAS1_C PF10421.9 ETO02239.1 - 0.078 12.5 0.2 0.089 12.3 0.2 1.1 1 0 0 1 1 1 0 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus Glucosamine_iso PF01182.20 ETO02240.1 - 0.16 11.8 0.0 0.19 11.6 0.0 1.1 1 0 0 1 1 1 0 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase DUF4533 PF15047.6 ETO02243.1 - 0.059 12.9 0.0 0.07 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) RAP80_UIM PF18282.1 ETO02243.1 - 0.11 12.3 0.2 0.23 11.3 0.2 1.5 1 0 0 1 1 1 0 RAP80 N-terminal ubiquitin interaction motif DUF682 PF05081.12 ETO02244.1 - 0.025 14.3 0.1 0.032 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF682) NYAP_C PF15452.6 ETO02244.1 - 0.93 9.3 6.5 0.72 9.6 2.4 2.0 1 1 1 2 2 2 0 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter DUF501 PF04417.12 ETO02244.1 - 8 6.3 9.3 0.99 9.2 1.8 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF501) U-box PF04564.15 ETO02245.1 - 2.3e-11 43.7 0.0 6e-11 42.4 0.0 1.7 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO02245.1 - 0.047 13.8 0.0 0.092 12.9 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein WD40 PF00400.32 ETO02246.1 - 1.6e-09 38.2 2.6 9.9e-05 23.0 0.1 3.9 4 2 0 4 4 4 2 WD domain, G-beta repeat WD40 PF00400.32 ETO02247.1 - 1.9e-12 47.5 0.8 1.7e-07 31.8 0.1 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02247.1 - 0.0031 17.8 0.0 0.0037 17.5 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain DUF851 PF05867.11 ETO02247.1 - 0.068 12.6 0.0 0.077 12.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF851) PBP1_TM PF14812.6 ETO02249.1 - 0.0022 18.3 2.8 0.0022 18.3 2.8 1.8 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 ETO02249.1 - 0.081 12.6 0.9 0.11 12.1 0.9 1.2 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ETO02249.1 - 1.2 9.6 8.2 1.8 9.0 8.2 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ank_3 PF13606.6 ETO02251.1 - 6.1e-08 32.3 0.1 0.00047 20.4 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO02251.1 - 7.4e-07 29.3 1.1 1.5e-05 25.2 0.1 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO02251.1 - 1.1e-06 29.2 0.3 3.3e-06 27.6 0.3 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO02251.1 - 3.8e-06 27.3 0.3 2.6e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) p25-alpha PF05517.12 ETO02251.1 - 0.00038 20.6 2.8 0.36 11.0 0.3 2.5 1 1 1 2 2 2 2 p25-alpha Ank PF00023.30 ETO02251.1 - 0.0013 19.1 0.0 0.016 15.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Activator-TraM PF11657.8 ETO02251.1 - 0.0013 18.6 4.7 0.77 9.6 0.2 3.2 3 0 0 3 3 3 2 Transcriptional activator TraM HEAT PF02985.22 ETO02251.1 - 0.0023 18.0 0.0 0.018 15.3 0.0 2.7 2 0 0 2 2 1 1 HEAT repeat ChaB PF06150.12 ETO02251.1 - 0.0063 17.1 1.7 0.48 11.0 0.1 2.6 2 0 0 2 2 2 1 ChaB HEAT_2 PF13646.6 ETO02251.1 - 0.012 16.0 0.0 0.053 13.9 0.0 2.1 2 0 0 2 2 1 0 HEAT repeats NLE PF08154.12 ETO02251.1 - 0.019 15.5 3.5 4 8.1 0.1 3.7 3 1 1 4 4 4 0 NLE (NUC135) domain Fe-S_assembly PF04384.13 ETO02251.1 - 0.065 13.8 3.3 2 9.1 0.2 3.7 4 0 0 4 4 3 0 Iron-sulphur cluster assembly Gluconate_2-dh3 PF13618.6 ETO02251.1 - 0.071 13.3 0.5 0.26 11.5 0.1 2.0 2 0 0 2 2 2 0 Gluconate 2-dehydrogenase subunit 3 HrcA PF01628.21 ETO02251.1 - 0.096 12.6 1.2 1.4 8.7 0.1 2.3 1 1 1 2 2 2 0 HrcA protein C terminal domain Barstar PF01337.18 ETO02251.1 - 0.16 12.0 2.1 3.8 7.6 0.1 3.4 3 1 0 3 3 3 0 Barstar (barnase inhibitor) Cnd1 PF12717.7 ETO02251.1 - 0.16 12.0 6.4 0.091 12.8 0.4 2.6 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Chalcone PF02431.15 ETO02251.1 - 0.3 10.4 3.2 3.3 7.1 0.3 2.2 1 1 0 2 2 2 0 Chalcone-flavanone isomerase Perilipin PF03036.16 ETO02252.1 - 0.0005 19.2 5.6 0.00055 19.1 5.6 1.0 1 0 0 1 1 1 1 Perilipin family Sigma70_ner PF04546.13 ETO02252.1 - 0.02 14.8 6.5 0.024 14.5 6.5 1.0 1 0 0 1 1 1 0 Sigma-70, non-essential region Adaptin_binding PF10199.9 ETO02252.1 - 0.023 15.3 5.7 0.029 15.0 5.7 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 POX PF07526.11 ETO02252.1 - 0.059 13.9 1.6 0.073 13.6 1.6 1.2 1 0 0 1 1 1 0 Associated with HOX RRN3 PF05327.11 ETO02252.1 - 0.069 11.7 7.1 0.071 11.7 7.1 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CENP-R PF06729.12 ETO02252.1 - 0.071 13.0 6.6 0.087 12.8 6.6 1.2 1 0 0 1 1 1 0 Kinetochore component, CENP-R Mif2_N PF15624.6 ETO02252.1 - 0.085 13.6 2.2 0.11 13.2 2.2 1.1 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal WD40 PF00400.32 ETO02254.1 - 9.9e-11 42.0 1.6 3.7e-06 27.5 0.0 2.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02254.1 - 0.034 14.4 0.1 0.29 11.5 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Tubulin_C PF03953.17 ETO02255.1 - 1.3e-29 102.9 0.1 1.9e-29 102.4 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Kelch_1 PF01344.25 ETO02256.1 - 0.00097 18.7 1.1 0.0054 16.3 0.0 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO02256.1 - 0.0026 17.7 0.2 2.1 8.5 0.1 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO02256.1 - 0.0055 16.7 0.1 1.3 9.1 0.1 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO02256.1 - 0.023 15.0 0.1 5.1 7.5 0.1 2.6 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO02256.1 - 0.027 14.5 0.0 14 5.8 0.0 2.9 3 0 0 3 3 3 0 Kelch motif BTD PF09270.10 ETO02256.1 - 0.028 14.7 0.1 0.045 14.0 0.1 1.4 1 0 0 1 1 1 0 Beta-trefoil DNA-binding domain PUB PF09409.10 ETO02258.1 - 0.058 13.3 2.6 0.51 10.3 2.6 2.2 1 1 0 1 1 1 0 PUB domain DUF3961 PF13106.6 ETO02258.1 - 0.092 12.4 1.0 0.15 11.7 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3961) Cyto_heme_lyase PF01265.17 ETO02260.1 - 0.21 11.2 3.8 0.24 11.0 3.8 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase zf-RRPl_C4 PF17026.5 ETO02260.1 - 0.68 10.1 8.3 0.043 13.9 2.2 1.9 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type RNase_H PF00075.24 ETO02261.1 - 0.00037 20.7 0.0 0.00048 20.3 0.0 1.3 1 0 0 1 1 1 1 RNase H DUF3450 PF11932.8 ETO02262.1 - 0.14 11.5 1.2 0.4 9.9 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Kelch_1 PF01344.25 ETO02263.1 - 2.9e-05 23.5 3.4 0.017 14.7 1.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO02263.1 - 0.0002 21.2 0.9 0.11 12.5 0.2 3.1 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO02263.1 - 0.00058 20.0 2.0 2 8.8 0.1 3.7 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO02263.1 - 0.0064 16.7 0.0 0.29 11.5 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain IBR PF01485.21 ETO02263.1 - 0.019 15.2 30.8 0.055 13.7 0.5 4.5 3 1 1 4 4 4 0 IBR domain, a half RING-finger domain Kelch_4 PF13418.6 ETO02263.1 - 0.056 13.5 0.0 0.36 10.9 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain LPD25 PF18840.1 ETO02263.1 - 0.089 13.4 0.1 0.089 13.4 0.1 2.2 3 0 0 3 3 3 0 Large polyvalent protein associated domain 25 Kelch_5 PF13854.6 ETO02263.1 - 0.36 10.9 9.7 9.1 6.4 0.5 4.6 5 0 0 5 5 5 0 Kelch motif Merozoite_SPAM PF07133.11 ETO02263.1 - 0.76 9.8 11.4 0.058 13.4 4.5 2.1 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) DUF2020 PF09449.10 ETO02264.1 - 0.079 12.8 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2020) PPR_2 PF13041.6 ETO02265.1 - 2e-14 53.5 6.2 1.5e-07 31.5 0.4 3.3 3 0 0 3 3 3 3 PPR repeat family PPR PF01535.20 ETO02265.1 - 1.1e-13 50.4 5.1 0.00018 21.5 0.1 4.4 4 0 0 4 4 4 4 PPR repeat PPR_3 PF13812.6 ETO02265.1 - 2.6e-09 37.0 1.3 3.2e-05 23.9 0.1 3.8 2 1 2 4 4 4 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO02265.1 - 3e-09 36.4 1.9 0.00028 20.5 0.0 3.9 4 0 0 4 4 4 3 PPR repeat PPR_long PF17177.4 ETO02265.1 - 5.8e-05 22.6 0.0 9.4e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF3636 PF12331.8 ETO02265.1 - 0.02 14.7 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) ATP13 PF12921.7 ETO02265.1 - 0.044 13.6 0.5 0.25 11.2 0.1 2.4 1 1 2 3 3 3 0 Mitochondrial ATPase expression SAP PF02037.27 ETO02266.1 - 5.1e-05 22.9 0.1 8.8e-05 22.2 0.1 1.4 1 0 0 1 1 1 1 SAP domain Exonuc_VII_L PF02601.15 ETO02268.1 - 0.055 13.0 4.4 0.07 12.7 4.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-Q PF13094.6 ETO02268.1 - 0.18 12.0 4.6 0.35 11.1 4.6 1.4 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Golgin_A5 PF09787.9 ETO02268.1 - 0.29 10.5 10.6 0.47 9.9 10.6 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Cytomega_UL84 PF06284.11 ETO02268.1 - 3.2 6.1 6.5 5 5.5 6.5 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Cwf_Cwc_15 PF04889.12 ETO02268.1 - 4.2 7.0 22.6 7.3 6.2 22.6 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CobT PF06213.12 ETO02268.1 - 4.5 6.6 8.4 6.2 6.1 8.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3_PI4_kinase PF00454.27 ETO02269.1 - 5e-42 144.4 0.1 5.2e-32 111.6 0.0 2.1 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase WD40 PF00400.32 ETO02270.1 - 2.2e-14 53.6 2.4 2.9e-05 24.7 0.4 3.8 3 2 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO02270.1 - 0.076 11.6 0.0 0.7 8.5 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02270.1 - 0.094 13.0 0.0 6.6 7.1 0.0 2.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_18 PF00704.28 ETO02271.1 - 1.6e-17 64.2 1.7 2.8e-17 63.4 1.7 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 HU-CCDC81_euk_1 PF14908.6 ETO02271.1 - 0.088 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 AlbA_2 PF04326.14 ETO02271.1 - 0.16 12.3 0.0 0.28 11.5 0.0 1.5 1 1 0 1 1 1 0 Putative DNA-binding domain HAD_SAK_2 PF18143.1 ETO02272.1 - 0.022 15.1 0.5 0.022 15.1 0.5 2.1 1 1 1 2 2 2 0 HAD domain in Swiss Army Knife RNA repair proteins DUF4376 PF14301.6 ETO02272.1 - 0.04 14.3 0.2 0.13 12.7 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4376) DnaJ PF00226.31 ETO02274.1 - 5.2e-09 36.1 2.7 5.5e-09 36.0 2.0 1.5 1 1 0 1 1 1 1 DnaJ domain DUF2039 PF10217.9 ETO02274.1 - 0.0005 20.4 2.1 0.00064 20.0 2.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) PKcGMP_CC PF16808.5 ETO02275.1 - 0.016 15.1 3.3 0.016 15.1 3.3 3.1 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Geminin PF07412.12 ETO02275.1 - 0.025 14.3 4.3 0.025 14.3 4.3 2.8 2 2 0 2 2 2 0 Geminin DUF641 PF04859.12 ETO02275.1 - 0.11 12.8 12.6 0.45 10.9 2.0 2.7 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) Phage_HK97_TLTM PF06120.11 ETO02275.1 - 6.2 5.9 21.0 0.28 10.3 14.8 1.8 2 0 0 2 2 2 0 Tail length tape measure protein MMR_HSR1 PF01926.23 ETO02276.1 - 6.3e-05 23.0 0.0 0.00042 20.4 0.0 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO02276.1 - 0.0006 19.8 0.0 0.0006 19.8 0.0 3.6 4 0 0 4 4 4 1 RsgA GTPase ABC_tran PF00005.27 ETO02276.1 - 0.00074 20.0 0.0 0.00074 20.0 0.0 2.9 3 1 1 4 4 4 1 ABC transporter AAA_29 PF13555.6 ETO02276.1 - 0.0052 16.5 0.0 0.014 15.1 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain PI_PP_I PF18363.1 ETO02276.1 - 0.015 15.4 1.3 1.3 9.2 0.7 3.3 3 0 0 3 3 2 0 Phosphoinositide phosphatase insertion domain AAA_16 PF13191.6 ETO02276.1 - 0.021 15.2 0.2 1.2 9.5 0.0 2.7 2 0 0 2 2 2 0 AAA ATPase domain Zeta_toxin PF06414.12 ETO02276.1 - 0.04 13.2 0.1 2 7.7 0.0 2.6 2 0 0 2 2 2 0 Zeta toxin AAA_22 PF13401.6 ETO02276.1 - 0.049 13.9 0.3 0.76 10.1 0.0 2.9 2 0 0 2 2 2 0 AAA domain CoA_trans PF01144.23 ETO02276.1 - 0.12 11.8 0.0 0.21 11.0 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase AAA_30 PF13604.6 ETO02276.1 - 0.12 12.0 1.3 7.1 6.3 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 ETO02276.1 - 0.16 12.2 0.2 1.6 9.0 0.0 2.6 2 1 1 3 3 3 0 AAA domain AAA_33 PF13671.6 ETO02276.1 - 0.38 10.9 1.7 1.2 9.3 0.2 2.5 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ETO02276.1 - 0.44 11.0 2.7 1.3 9.5 0.1 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Cucumopine_C PF18631.1 ETO02277.1 - 0.0041 17.1 1.6 2 8.4 0.0 3.6 4 0 0 4 4 4 2 Cucumopine synthase C-terminal helical bundle domain ATG2_CAD PF13329.6 ETO02277.1 - 0.012 15.4 0.5 0.012 15.4 0.5 2.4 3 0 0 3 3 3 0 Autophagy-related protein 2 CAD motif Acyl-CoA_dh_C PF12806.7 ETO02277.1 - 0.018 15.2 0.3 3.7 7.7 0.0 3.4 2 2 2 4 4 4 0 Acetyl-CoA dehydrogenase C-terminal like TetR PF13972.6 ETO02277.1 - 0.047 13.4 2.2 0.65 9.7 0.3 3.4 3 0 0 3 3 3 0 Bacterial transcriptional repressor Peptidase_S39 PF02122.15 ETO02277.1 - 0.086 12.4 2.0 0.16 11.5 2.0 1.4 1 0 0 1 1 1 0 Peptidase S39 DUF1192 PF06698.11 ETO02277.1 - 0.16 12.1 0.2 0.16 12.1 0.2 4.3 3 2 1 4 4 4 0 Protein of unknown function (DUF1192) DASH_Dad1 PF08649.10 ETO02277.1 - 0.92 9.8 7.1 17 5.7 0.0 4.1 3 0 0 3 3 3 0 DASH complex subunit Dad1 DUF4798 PF16055.5 ETO02277.1 - 1.3 9.3 7.5 1.6 9.0 4.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4798) DUF4407 PF14362.6 ETO02277.1 - 3.5 6.9 14.8 19 4.5 14.6 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 ETO02277.1 - 8.5 6.7 34.2 5.3 7.3 0.5 6.0 4 1 0 6 6 6 0 Domain of unknown function (DUF5082) PPR_3 PF13812.6 ETO02278.1 - 0.0005 20.1 0.1 0.0013 18.8 0.1 1.7 1 0 0 1 1 1 1 Pentatricopeptide repeat domain Toxin-deaminase PF14424.6 ETO02278.1 - 0.013 15.6 0.6 0.016 15.3 0.6 1.1 1 0 0 1 1 1 0 The BURPS668_1122 family of deaminases TPR_12 PF13424.6 ETO02279.1 - 5e-24 84.4 5.8 1.7e-19 69.9 0.8 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02279.1 - 3.4e-22 77.3 28.1 1.9e-09 36.9 2.5 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02279.1 - 7.5e-22 75.6 16.7 3.2e-08 33.1 1.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02279.1 - 2.9e-18 65.1 11.5 9.4e-07 28.5 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02279.1 - 2.4e-14 52.2 6.5 1.4e-05 24.8 0.1 3.7 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02279.1 - 2.3e-13 49.6 22.8 2e-05 24.1 0.8 4.7 3 2 2 5 5 5 3 TPR repeat TPR_8 PF13181.6 ETO02279.1 - 3e-13 48.8 22.4 3.8e-06 26.7 1.8 3.9 4 1 1 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02279.1 - 6.8e-13 49.0 0.1 2.2e-05 25.0 0.0 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02279.1 - 1.7e-10 40.8 0.0 0.14 13.1 0.0 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02279.1 - 2.4e-10 40.3 3.8 0.0042 17.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.6 ETO02279.1 - 1.1e-07 31.5 5.6 1.4e-07 31.3 5.6 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.9 ETO02279.1 - 1.3e-07 30.9 2.0 0.0012 18.2 0.2 3.3 3 0 0 3 3 3 1 SHNi-TPR ANAPC3 PF12895.7 ETO02279.1 - 1.5e-06 28.3 14.2 0.047 13.9 3.6 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 ETO02279.1 - 4.5e-06 26.5 5.5 0.042 13.5 0.1 3.0 1 1 2 3 3 3 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETO02279.1 - 5.2e-06 26.9 4.9 0.0017 18.8 1.2 2.7 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02279.1 - 7e-06 26.1 23.0 0.029 14.7 0.1 4.7 4 2 0 4 4 4 3 Tetratricopeptide repeat MIT PF04212.18 ETO02279.1 - 7e-06 26.0 12.5 0.03 14.4 2.1 3.2 3 0 0 3 3 3 3 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO02279.1 - 7.4e-05 22.6 11.1 0.00022 21.0 4.3 2.0 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 ETO02279.1 - 9.8e-05 22.3 6.8 0.0095 15.9 1.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat PPR PF01535.20 ETO02279.1 - 0.00017 21.6 3.1 0.14 12.4 0.1 3.4 3 0 0 3 3 3 1 PPR repeat Prefoldin PF02996.17 ETO02279.1 - 0.00034 20.5 4.5 0.053 13.4 0.2 2.9 1 1 2 3 3 3 2 Prefoldin subunit TPR_15 PF13429.6 ETO02279.1 - 0.0025 17.1 0.7 0.0069 15.6 0.7 1.7 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_5 PF12688.7 ETO02279.1 - 0.0028 17.9 0.3 0.23 11.7 0.0 2.9 2 1 1 3 3 3 1 Tetratrico peptide repeat PPR_2 PF13041.6 ETO02279.1 - 0.0036 17.5 3.3 4.5 7.6 0.1 3.3 3 0 0 3 3 3 1 PPR repeat family Sel1 PF08238.12 ETO02279.1 - 0.0054 17.4 5.7 1.2 10.0 0.1 3.2 3 1 0 3 3 3 2 Sel1 repeat DUF5113 PF17140.4 ETO02279.1 - 0.0057 16.5 13.3 0.17 11.7 1.8 3.1 1 1 2 3 3 3 2 Domain of unknown function (DUF5113) Vta1_C PF18097.1 ETO02279.1 - 0.013 15.1 0.1 14 5.5 0.0 3.2 3 0 0 3 3 3 0 Vta1 C-terminal domain TPR_9 PF13371.6 ETO02279.1 - 0.022 14.9 0.0 1.9 8.7 0.0 2.3 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETO02279.1 - 0.033 14.2 1.6 0.21 11.7 0.6 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) SMBP PF16785.5 ETO02279.1 - 0.049 13.9 0.0 8.8 6.6 0.0 2.6 1 1 1 2 2 2 0 Small metal-binding protein Rapsyn_N PF10579.9 ETO02279.1 - 0.055 13.6 3.0 10 6.3 0.2 3.1 1 1 2 3 3 3 0 Rapsyn N-terminal myristoylation and linker region NSF PF02071.20 ETO02279.1 - 0.085 13.6 10.1 8.2 7.7 0.3 4.4 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat SPO22 PF08631.10 ETO02279.1 - 0.19 11.2 10.0 3 7.3 0.3 2.9 1 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like Sda PF08970.10 ETO02279.1 - 1.2 8.9 3.9 11 5.8 0.1 3.0 3 0 0 3 3 3 0 Sporulation inhibitor A Sec5 PF15469.6 ETO02279.1 - 3.6 7.3 13.7 1.4e+03 -1.1 13.7 2.9 1 1 0 1 1 1 0 Exocyst complex component Sec5 DUF4968 PF16338.5 ETO02281.1 - 0.17 12.2 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4968) NOA36 PF06524.12 ETO02282.1 - 0.066 12.5 9.4 0.069 12.5 9.4 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 ETO02282.1 - 0.07 12.3 11.0 0.069 12.3 11.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sigma70_ner PF04546.13 ETO02282.1 - 0.28 11.1 4.1 0.28 11.1 4.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region RRN3 PF05327.11 ETO02282.1 - 0.76 8.2 3.4 0.62 8.5 3.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.13 ETO02282.1 - 2.8 8.0 8.2 2.6 8.1 8.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Ank_2 PF12796.7 ETO02283.1 - 0.001 19.6 0.0 0.0016 19.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) RsbRD_N PF14361.6 ETO02283.1 - 0.048 14.3 2.3 0.51 11.1 0.0 2.2 2 0 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain SNAD2 PF18745.1 ETO02284.1 - 0.013 15.2 0.5 0.039 13.7 0.5 1.7 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 2 FUN14 PF04930.15 ETO02285.1 - 1.7e-12 47.5 5.6 3.1e-12 46.8 5.6 1.4 1 0 0 1 1 1 1 FUN14 family LupA PF18242.1 ETO02285.1 - 0.016 14.9 0.0 0.026 14.2 0.0 1.3 1 0 0 1 1 1 0 Legionella ubiquitin-specific protease A domain Copine PF07002.16 ETO02286.1 - 6e-20 71.6 0.2 6.6e-20 71.5 0.2 1.0 1 0 0 1 1 1 1 Copine Cons_hypoth698 PF03601.14 ETO02286.1 - 0.017 14.0 0.1 0.02 13.8 0.1 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein 698 RVT_1 PF00078.27 ETO02287.1 - 3e-20 72.7 10.4 1.7e-19 70.2 8.1 2.9 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) PRF PF06875.11 ETO02287.1 - 0.075 12.5 0.2 0.17 11.3 0.2 1.6 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF RST PF12174.8 ETO02287.1 - 0.66 9.9 4.2 5.1 7.1 0.4 3.6 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain IFS PF16718.5 ETO02290.1 - 0.019 15.1 0.5 0.028 14.5 0.5 1.2 1 0 0 1 1 1 0 Immunity factor for SPN ANAPC15 PF15243.6 ETO02290.1 - 0.045 14.2 5.3 0.084 13.3 2.5 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 DUF913 PF06025.12 ETO02291.1 - 0.05 12.6 4.2 0.07 12.1 4.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SURF2 PF05477.11 ETO02291.1 - 0.085 12.5 9.9 0.12 12.1 9.9 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DDHD PF02862.17 ETO02291.1 - 0.14 12.3 4.3 0.21 11.7 4.3 1.3 1 0 0 1 1 1 0 DDHD domain Sporozoite_P67 PF05642.11 ETO02291.1 - 0.14 10.2 10.0 0.16 10.0 10.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CobT PF06213.12 ETO02291.1 - 0.15 11.4 10.5 0.18 11.1 10.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SAPS PF04499.15 ETO02291.1 - 0.62 8.8 7.1 0.68 8.6 7.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Spt20 PF12090.8 ETO02291.1 - 1.3 8.6 10.8 1.6 8.3 10.8 1.2 1 0 0 1 1 1 0 Spt20 family Cwf_Cwc_15 PF04889.12 ETO02291.1 - 1.6 8.4 17.2 1.9 8.1 17.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pns11_12 PF17464.2 ETO02291.1 - 1.7 8.3 11.9 2.2 8.0 11.9 1.1 1 0 0 1 1 1 0 Non-structural protein 11 and 12 Presenilin PF01080.17 ETO02291.1 - 1.8 7.3 8.1 2 7.1 8.1 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO02291.1 - 2.3 8.0 9.2 2.7 7.7 9.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 U79_P34 PF03064.16 ETO02291.1 - 2.4 7.4 10.2 2.9 7.2 10.2 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MCM_bind PF09739.9 ETO02291.1 - 3.4 6.0 7.7 4.3 5.7 7.7 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NPR3 PF03666.13 ETO02291.1 - 3.5 6.3 10.9 3.7 6.2 10.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Hid1 PF12722.7 ETO02291.1 - 4.7 5.2 6.8 4.5 5.3 6.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CENP-B_dimeris PF09026.10 ETO02291.1 - 5.4 7.5 8.7 0.63 10.5 4.6 1.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDC45 PF02724.14 ETO02291.1 - 6.2 5.0 9.4 6.5 4.9 9.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 ETO02294.1 - 0.00079 19.0 1.5 0.00094 18.7 1.5 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 CEL_III_C PF18054.1 ETO02294.1 - 0.0071 16.4 0.7 0.0092 16.0 0.7 1.1 1 0 0 1 1 1 1 CEL-III C-terminal TolA_bind_tri PF16331.5 ETO02295.1 - 0.00065 19.7 10.8 0.0012 18.9 8.9 2.0 1 1 1 2 2 2 1 TolA binding protein trimerisation DUF3450 PF11932.8 ETO02295.1 - 0.0038 16.6 12.1 0.0041 16.5 12.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) NYD-SP28_assoc PF14775.6 ETO02295.1 - 0.0041 17.2 1.7 0.0041 17.2 1.7 2.1 1 1 1 2 2 2 1 Sperm tail C-terminal domain DUF1204 PF06721.11 ETO02295.1 - 0.0058 16.1 1.9 0.0065 15.9 1.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1204) Herpes_UL6 PF01763.16 ETO02295.1 - 0.0075 14.8 10.8 0.0073 14.9 10.8 1.0 1 0 0 1 1 1 1 Herpesvirus UL6 like ZapB PF06005.12 ETO02295.1 - 0.0075 16.7 13.4 0.022 15.2 13.2 1.8 1 1 0 1 1 1 1 Cell division protein ZapB DUF948 PF06103.11 ETO02295.1 - 0.0077 16.5 3.2 0.035 14.4 3.1 1.8 1 1 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 ETO02295.1 - 0.0089 16.0 7.0 0.01 15.8 7.0 1.1 1 0 0 1 1 1 1 Laminin Domain II CENP-Q PF13094.6 ETO02295.1 - 0.0097 16.1 9.6 0.0099 16.1 9.6 1.0 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit BLOC1_2 PF10046.9 ETO02295.1 - 0.014 15.6 9.7 0.048 14.0 9.7 1.8 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LPP PF04728.13 ETO02295.1 - 0.015 15.6 7.9 0.2 12.0 1.6 2.2 1 1 1 2 2 2 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 ETO02295.1 - 0.032 14.3 14.8 0.081 13.0 14.8 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_MT_bd PF06657.13 ETO02295.1 - 0.052 14.0 5.1 0.074 13.5 5.1 1.3 1 1 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Filament PF00038.21 ETO02295.1 - 0.052 13.1 12.6 0.063 12.9 12.6 1.2 1 0 0 1 1 1 0 Intermediate filament protein RmuC PF02646.16 ETO02295.1 - 0.069 12.3 9.0 0.052 12.7 7.7 1.4 1 1 0 1 1 1 0 RmuC family SbsC_C PF18058.1 ETO02295.1 - 0.077 13.2 8.4 0.099 12.9 8.4 1.3 1 0 0 1 1 1 0 SbsC C-terminal domain DUF1664 PF07889.12 ETO02295.1 - 0.088 12.9 8.4 0.098 12.7 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF745 PF05335.13 ETO02295.1 - 0.099 12.4 10.1 0.11 12.2 10.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF745) T3SSipB PF16535.5 ETO02295.1 - 0.12 12.9 8.4 0.12 12.8 8.4 1.0 1 0 0 1 1 1 0 Type III cell invasion protein SipB TACC_C PF05010.14 ETO02295.1 - 0.12 12.1 16.9 0.12 12.1 16.9 1.0 1 0 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ADIP PF11559.8 ETO02295.1 - 0.12 12.4 13.8 0.14 12.3 13.8 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.11 ETO02295.1 - 0.12 12.7 6.7 0.12 12.7 3.4 2.1 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF4471 PF14740.6 ETO02295.1 - 0.15 11.3 5.5 0.16 11.2 5.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) UPF0242 PF06785.11 ETO02295.1 - 0.15 12.1 15.7 0.16 12.1 15.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 ETO02295.1 - 0.15 12.7 8.8 0.26 11.9 8.8 1.5 1 1 0 1 1 1 0 Initiation control protein YabA DUF724 PF05266.14 ETO02295.1 - 0.18 11.6 11.7 0.21 11.4 11.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.9 ETO02295.1 - 0.22 10.5 11.7 0.24 10.4 11.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Wbp11 PF09429.10 ETO02295.1 - 0.24 11.8 12.8 0.3 11.5 12.8 1.2 1 0 0 1 1 1 0 WW domain binding protein 11 bZIP_1 PF00170.21 ETO02295.1 - 0.28 11.3 19.5 2.1 8.5 0.7 2.5 1 1 1 2 2 2 0 bZIP transcription factor Neugrin PF06413.11 ETO02295.1 - 0.33 10.9 6.7 0.37 10.8 6.7 1.0 1 0 0 1 1 1 0 Neugrin AI-2E_transport PF01594.16 ETO02295.1 - 0.39 9.8 2.3 0.55 9.3 2.3 1.3 1 1 0 1 1 1 0 AI-2E family transporter Erp_C PF06780.11 ETO02295.1 - 0.48 10.4 7.4 0.54 10.3 7.4 1.1 1 0 0 1 1 1 0 Erp protein C-terminus YlqD PF11068.8 ETO02295.1 - 0.64 10.4 15.0 1.5 9.2 15.0 1.6 1 1 0 1 1 1 0 YlqD protein Nup54 PF13874.6 ETO02295.1 - 0.76 9.9 9.7 2.1 8.5 9.7 1.6 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 Spc7 PF08317.11 ETO02295.1 - 0.86 8.4 15.0 0.89 8.4 15.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 ETO02295.1 - 1.1 9.6 11.8 1.7 8.9 11.8 1.4 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CENP-H PF05837.12 ETO02295.1 - 1.2 9.5 11.7 0.24 11.8 7.9 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) SecA_DEAD PF07517.14 ETO02295.1 - 1.2 8.3 6.6 1.3 8.2 6.6 1.1 1 0 0 1 1 1 0 SecA DEAD-like domain IFT57 PF10498.9 ETO02295.1 - 1.3 7.9 14.6 1.3 7.9 14.6 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SlyX PF04102.12 ETO02295.1 - 1.4 9.6 7.6 20 5.9 7.6 2.1 1 1 0 1 1 1 0 SlyX DUF2408 PF10303.9 ETO02295.1 - 1.6 9.3 11.7 1.6 9.3 11.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) Sec16 PF12932.7 ETO02295.1 - 1.6 9.4 5.7 1.8 9.2 3.7 1.9 1 1 1 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region XkdW PF09636.10 ETO02295.1 - 1.6 8.8 8.9 3.6 7.7 1.6 2.1 1 1 1 2 2 2 0 XkdW protein Sec2p PF06428.11 ETO02295.1 - 1.9 8.5 16.1 17 5.5 16.1 1.9 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p V_ATPase_I PF01496.19 ETO02295.1 - 2 6.2 11.1 2 6.2 11.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fzo_mitofusin PF04799.13 ETO02295.1 - 2.2 7.8 11.0 2.5 7.6 11.0 1.1 1 0 0 1 1 1 0 fzo-like conserved region DUF4094 PF13334.6 ETO02295.1 - 2.4 8.7 8.8 1.4 9.4 2.9 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DivIC PF04977.15 ETO02295.1 - 2.6 7.9 12.9 0.63 9.8 3.5 2.1 1 1 1 2 2 2 0 Septum formation initiator HemX PF04375.14 ETO02295.1 - 2.8 7.1 13.7 3.1 7.0 13.7 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DASH_Hsk3 PF08227.11 ETO02295.1 - 3.3 8.2 11.1 1.1 9.7 0.4 2.7 2 1 1 3 3 3 0 DASH complex subunit Hsk3 like Phage_GPO PF05929.11 ETO02295.1 - 4.7 6.8 9.9 4.8 6.7 9.9 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FliD_N PF02465.18 ETO02295.1 - 4.8 7.9 14.9 5.2 7.8 5.0 2.0 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus bZIP_2 PF07716.15 ETO02295.1 - 5.8 7.1 17.3 25 5.1 12.4 2.8 1 1 1 2 2 2 0 Basic region leucine zipper IKKbetaNEMObind PF12179.8 ETO02295.1 - 7.2 6.7 9.1 0.71 10.0 1.8 2.5 2 1 1 3 3 3 0 I-kappa-kinase-beta NEMO binding domain MRPL52 PF18699.1 ETO02295.1 - 7.8 6.8 14.0 28 5.0 0.5 2.1 1 1 1 2 2 2 0 Mitoribosomal protein mL52 HTH_52 PF18576.1 ETO02296.1 - 0.0059 16.8 0.9 0.13 12.5 0.0 2.4 2 0 0 2 2 2 1 Helix-turn-helix domain WD40 PF00400.32 ETO02298.1 - 6e-24 83.9 14.5 1.1e-08 35.5 0.6 6.8 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02298.1 - 1.9e-11 44.1 2.9 0.012 15.9 0.0 5.4 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO02298.1 - 2.1e-08 33.5 0.4 0.0013 17.8 0.0 4.2 2 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO02298.1 - 0.00016 21.1 8.3 0.025 13.9 0.4 3.8 2 1 2 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO02298.1 - 0.0033 17.3 0.0 3 7.9 0.0 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO02298.1 - 0.0048 15.6 9.3 0.67 8.5 2.3 3.8 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO02298.1 - 0.025 14.7 0.1 1.7 8.8 0.0 3.0 2 2 1 3 3 3 0 Family of unknown function (DUF5570) zf-C3HC4_2 PF13923.6 ETO02299.1 - 0.49 10.3 8.2 2.1 8.2 5.4 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Bul1_C PF04426.12 ETO02300.1 - 0.0085 15.5 2.0 0.0098 15.3 2.0 1.0 1 0 0 1 1 1 1 Bul1 C terminus FANCI_S1 PF14675.6 ETO02300.1 - 0.023 14.2 0.8 0.03 13.9 0.8 1.1 1 0 0 1 1 1 0 FANCI solenoid 1 EIIBC-GUT_N PF03612.14 ETO02300.1 - 0.037 13.8 0.6 0.045 13.5 0.6 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PI3K_1B_p101 PF10486.9 ETO02300.1 - 0.04 11.7 4.3 0.049 11.4 4.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SAP18 PF06487.12 ETO02300.1 - 0.071 13.3 1.3 0.11 12.6 1.0 1.4 1 1 1 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) YacG PF03884.14 ETO02300.1 - 0.17 11.6 1.0 0.36 10.6 1.0 1.5 1 0 0 1 1 1 0 DNA gyrase inhibitor YacG Adhes-Ig_like PF09085.10 ETO02300.1 - 2.5 8.2 6.7 0.22 11.6 0.7 1.9 1 1 1 2 2 2 0 Adhesion molecule, immunoglobulin-like CdiI PF07262.11 ETO02301.1 - 0.21 11.3 1.9 0.4 10.4 1.9 1.4 1 0 0 1 1 1 0 CDI immunity protein U-box PF04564.15 ETO02302.1 - 3.7e-09 36.6 0.1 2.5e-08 33.9 0.0 2.5 2 0 0 2 2 2 1 U-box domain Kelch_6 PF13964.6 ETO02302.1 - 3.4e-06 27.1 1.2 0.16 12.3 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO02302.1 - 0.00014 21.4 0.7 0.0072 15.9 0.3 3.0 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO02302.1 - 0.016 15.1 0.4 11 6.2 0.0 3.4 3 0 0 3 3 3 0 Kelch motif zf-NOSIP PF15906.5 ETO02302.1 - 0.057 13.6 0.0 0.18 12.0 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein AAA_28 PF13521.6 ETO02302.1 - 0.16 12.2 4.4 6.9 6.9 0.7 2.9 2 1 0 2 2 2 0 AAA domain Kelch_6 PF13964.6 ETO02303.1 - 5.2e-06 26.6 0.5 2.8e-05 24.3 0.1 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO02303.1 - 8.2e-05 22.1 0.2 0.00032 20.2 0.2 2.0 1 0 0 1 1 1 1 Kelch motif U-box PF04564.15 ETO02303.1 - 0.001 19.2 0.5 0.001 19.2 0.5 2.4 3 0 0 3 3 3 1 U-box domain Kelch_4 PF13418.6 ETO02303.1 - 0.028 14.4 0.3 0.074 13.1 0.1 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Apo-CIII PF05778.12 ETO02303.1 - 0.04 13.6 2.7 0.15 11.7 2.7 2.0 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) Kelch_3 PF13415.6 ETO02303.1 - 0.043 14.1 0.1 0.24 11.7 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO02303.1 - 0.058 13.4 0.2 0.13 12.3 0.2 1.6 1 0 0 1 1 1 0 Kelch motif Arnt_C PF18583.1 ETO02303.1 - 1.4 8.6 4.5 0.41 10.3 0.2 2.2 2 0 0 2 2 2 0 Aminoarabinose transferase C-terminal domain DUF812 PF05667.11 ETO02305.1 - 0.1 11.5 18.7 0.14 11.0 18.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF641 PF04859.12 ETO02305.1 - 0.86 9.9 16.3 2.3 8.5 7.3 2.9 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) LMBR1 PF04791.16 ETO02305.1 - 2.3 7.0 6.2 2.4 7.0 6.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF1664 PF07889.12 ETO02305.1 - 3.3 7.8 9.7 3 7.9 6.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF1043 PF06295.12 ETO02305.1 - 5.9 6.9 19.2 0.14 12.1 9.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1043) FliD_N PF02465.18 ETO02305.1 - 7.7 7.3 17.9 8 7.2 4.5 3.5 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus DUF2390 PF09523.10 ETO02306.1 - 0.071 13.4 1.2 0.16 12.3 0.2 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2390) HSBP1 PF06825.12 ETO02307.1 - 0.00032 20.5 3.4 0.00032 20.5 3.4 3.4 4 0 0 4 4 4 1 Heat shock factor binding protein 1 LMBR1 PF04791.16 ETO02307.1 - 0.035 13.0 16.4 0.044 12.7 16.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Hydantoinase_A PF01968.18 ETO02307.1 - 0.06 12.6 0.8 0.1 11.9 0.8 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase WD40 PF00400.32 ETO02308.1 - 6.7e-12 45.7 2.7 7.2e-05 23.5 0.5 2.9 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02308.1 - 0.022 15.0 0.1 0.16 12.2 0.1 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain FAM221 PF14753.6 ETO02310.1 - 0.013 15.1 0.9 0.017 14.7 0.9 1.3 1 0 0 1 1 1 0 Protein FAM221A/B Tubulin PF00091.25 ETO02311.1 - 5.3e-21 75.7 0.1 1.6e-20 74.1 0.0 1.6 1 1 1 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO02311.1 - 0.0053 16.0 0.0 0.008 15.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Lipase_3 PF01764.25 ETO02311.1 - 0.038 13.8 0.0 0.056 13.3 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) WD40 PF00400.32 ETO02312.1 - 0.0006 20.6 0.7 13 6.9 0.0 5.3 4 2 0 4 4 4 1 WD domain, G-beta repeat DUF4564 PF15169.6 ETO02312.1 - 0.009 15.7 0.1 0.019 14.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) HELP PF03451.14 ETO02313.1 - 0.15 11.9 0.6 0.57 10.1 0.3 2.0 1 1 1 2 2 2 0 HELP motif ETRAMP PF09716.10 ETO02313.1 - 0.87 9.7 6.8 1.1 9.4 6.8 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO02315.1 - 2.1e-40 135.9 10.1 3.1e-08 34.1 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02315.1 - 5.2e-17 61.9 1.3 0.00039 20.6 0.0 4.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO02315.1 - 2.2e-09 37.5 0.8 0.00012 22.0 0.1 2.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO02315.1 - 1.9e-08 34.0 1.7 0.00052 19.4 0.1 2.7 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO02315.1 - 1.9e-07 30.2 0.8 0.31 9.6 0.0 3.9 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO02315.1 - 1.1e-05 24.6 0.0 0.68 8.8 0.0 4.3 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO02315.1 - 0.11 12.5 3.5 24 5.0 0.0 3.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat EGF PF00008.27 ETO02316.1 - 0.00018 21.7 4.6 0.00034 20.9 4.6 1.4 1 0 0 1 1 1 1 EGF-like domain hEGF PF12661.7 ETO02316.1 - 0.0015 19.1 3.7 0.0015 19.1 3.7 1.7 2 0 0 2 2 2 1 Human growth factor-like EGF CRPA PF05745.11 ETO02316.1 - 0.0058 16.6 0.1 0.0084 16.1 0.1 1.2 1 0 0 1 1 1 1 Chlamydia 15 kDa cysteine-rich outer membrane protein (CRPA) EGF_2 PF07974.13 ETO02316.1 - 0.022 15.1 9.5 0.031 14.7 9.5 1.2 1 0 0 1 1 1 0 EGF-like domain SP_C-Propep PF08999.10 ETO02316.1 - 0.047 13.5 2.0 0.072 12.9 2.0 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide ECSCR PF15820.5 ETO02316.1 - 0.26 11.1 4.3 0.43 10.4 4.3 1.4 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator TMEM154 PF15102.6 ETO02316.1 - 1.2 9.0 4.0 0.24 11.3 0.7 1.6 2 0 0 2 2 2 0 TMEM154 protein family Laminin_EGF PF00053.24 ETO02316.1 - 1.5 9.1 9.5 2.5 8.3 9.5 1.3 1 0 0 1 1 1 0 Laminin EGF domain WD40 PF00400.32 ETO02317.1 - 0.11 13.4 2.8 0.74 10.8 0.1 2.8 2 2 0 2 2 2 0 WD domain, G-beta repeat Zip PF02535.22 ETO02318.1 - 0.32 10.2 0.8 0.36 10.0 0.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_C14 PF00656.22 ETO02319.1 - 5.7e-07 29.7 0.1 8.1e-07 29.2 0.1 1.3 1 0 0 1 1 1 1 Caspase domain Meis_PKNOX_N PF16493.5 ETO02319.1 - 0.013 15.8 0.2 0.046 14.0 0.0 2.0 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 THOC7 PF05615.13 ETO02319.1 - 0.14 12.4 0.0 0.35 11.2 0.0 1.6 1 0 0 1 1 1 0 Tho complex subunit 7 TMPIT PF07851.13 ETO02320.1 - 0.3 10.3 5.3 0.35 10.1 5.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF1690 PF07956.11 ETO02320.1 - 0.38 11.2 8.8 0.47 10.9 8.8 1.2 1 0 0 1 1 1 0 Protein of Unknown function (DUF1690) DUF4407 PF14362.6 ETO02320.1 - 0.56 9.5 2.6 0.71 9.2 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 ETO02320.1 - 0.95 9.5 7.3 1.3 9.1 6.1 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) MtrG PF04210.13 ETO02320.1 - 1.7 8.6 4.6 12 5.8 4.6 2.4 1 1 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G FemAB PF02388.16 ETO02320.1 - 2.2 7.1 8.4 2.6 6.8 8.4 1.1 1 0 0 1 1 1 0 FemAB family DUF5395 PF17373.2 ETO02320.1 - 8.9 7.0 6.8 31 5.3 3.6 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5395) RecO_C PF02565.15 ETO02321.1 - 1.1e-17 64.3 0.3 1.4e-17 63.9 0.3 1.1 1 0 0 1 1 1 1 Recombination protein O C terminal RecO_N PF11967.8 ETO02321.1 - 4.9e-05 23.2 0.0 8.4e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Recombination protein O N terminal DUF5617 PF18493.1 ETO02322.1 - 0.0074 16.4 1.2 0.093 12.8 0.1 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF5617) FliG_N PF14842.6 ETO02322.1 - 0.047 14.2 0.5 0.29 11.7 0.2 2.5 3 0 0 3 3 3 0 FliG N-terminal domain DUF5344 PF17279.2 ETO02322.1 - 0.12 12.9 3.2 3.1 8.4 0.0 3.6 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Cnd1 PF12717.7 ETO02324.1 - 4.5e-06 26.8 1.0 0.00098 19.2 0.2 2.0 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Bromodomain PF00439.25 ETO02324.1 - 0.016 15.3 0.1 4 7.6 0.1 2.2 2 0 0 2 2 2 0 Bromodomain HEAT PF02985.22 ETO02324.1 - 0.058 13.7 0.0 15 6.2 0.0 2.7 3 0 0 3 3 3 0 HEAT repeat GIT1_C PF12205.8 ETO02324.1 - 0.084 13.0 0.9 4.1 7.6 0.1 2.1 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term DUF2789 PF10982.8 ETO02324.1 - 0.086 13.0 0.3 12 6.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2789) TSC22 PF01166.18 ETO02324.1 - 0.1 12.9 3.7 3.4 8.0 0.5 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family IATP PF04568.12 ETO02324.1 - 0.14 12.6 0.1 18 5.8 0.1 2.2 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP Baculo_LEF-10 PF07206.11 ETO02324.1 - 0.19 11.9 2.5 8.4 6.6 0.2 2.1 2 0 0 2 2 2 0 Baculovirus late expression factor 10 (LEF-10) CCDC-167 PF15188.6 ETO02324.1 - 0.27 11.6 2.2 7.3 7.0 0.4 2.5 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 tRNA-synt_1 PF00133.22 ETO02325.1 - 0.00015 20.1 0.0 0.00015 20.1 0.0 2.5 1 1 2 3 3 3 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETO02325.1 - 0.00021 20.2 0.3 0.00037 19.4 0.3 1.5 1 1 0 1 1 1 1 tRNA synthetases class I (M) Mlh1_C PF16413.5 ETO02325.1 - 0.016 14.6 1.4 0.021 14.2 1.4 1.1 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus DUF4611 PF15387.6 ETO02325.1 - 0.031 14.5 3.8 0.046 13.9 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Connexin PF00029.19 ETO02325.1 - 0.12 12.1 1.0 0.16 11.7 1.0 1.2 1 0 0 1 1 1 0 Connexin Jak1_Phl PF17887.1 ETO02325.1 - 1.2 9.1 6.3 1.8 8.5 6.3 1.2 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain Methyltransf_25 PF13649.6 ETO02327.1 - 0.011 16.5 0.0 0.018 15.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ETO02327.1 - 0.056 14.1 0.0 0.1 13.3 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain MMU163 PF17119.5 ETO02327.1 - 0.08 12.1 0.3 1.3 8.1 0.5 2.1 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis Minor_tail_Z PF06763.11 ETO02328.1 - 0.0016 18.3 0.6 1.3 8.7 0.3 3.2 1 1 1 2 2 2 1 Prophage minor tail protein Z (GPZ) Trigger_C PF05698.14 ETO02328.1 - 0.0033 17.4 16.2 9.8 6.2 14.6 3.5 1 1 1 2 2 2 1 Bacterial trigger factor protein (TF) C-terminus GerPC PF10737.9 ETO02328.1 - 0.013 15.5 10.4 0.03 14.4 1.4 2.1 1 1 1 2 2 2 0 Spore germination protein GerPC DUF445 PF04286.12 ETO02328.1 - 0.018 14.9 10.6 0.024 14.5 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) DUF2267 PF10025.9 ETO02328.1 - 0.034 14.4 10.0 0.44 10.8 4.5 3.6 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) HI0933_like PF03486.14 ETO02328.1 - 0.052 12.2 1.8 0.56 8.8 1.1 1.9 1 1 1 2 2 2 0 HI0933-like protein DUF668 PF05003.12 ETO02328.1 - 0.19 12.2 1.2 4.6 7.8 1.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF668) RNase_J_C PF17770.1 ETO02328.1 - 0.27 12.3 4.6 26 6.0 0.2 2.9 1 1 1 2 2 2 0 Ribonuclease J C-terminal domain Ribosomal_L12 PF00542.19 ETO02328.1 - 0.35 11.3 8.7 14 6.1 0.9 3.8 1 1 2 3 3 3 0 Ribosomal protein L7/L12 C-terminal domain DUF3819 PF12842.7 ETO02328.1 - 0.45 10.5 2.3 17 5.3 2.3 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3819) DUF1525 PF07511.11 ETO02328.1 - 0.51 10.5 13.4 43 4.3 2.7 4.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1525) pP_pnuc_2 PF18166.1 ETO02328.1 - 0.64 10.1 8.4 10 6.2 0.4 3.4 1 1 2 3 3 3 0 Predicted pPIWI-associating nuclease WASH-7_mid PF14744.6 ETO02328.1 - 0.98 8.4 4.4 7 5.6 1.4 2.0 1 1 1 2 2 2 0 WASH complex subunit 7 Band_7 PF01145.25 ETO02328.1 - 3.7 7.5 11.0 1.4e+03 -0.8 11.0 3.5 1 1 0 1 1 1 0 SPFH domain / Band 7 family FAM75 PF14650.6 ETO02328.1 - 6.3 6.2 10.9 8.5 5.8 10.1 1.5 1 1 0 1 1 1 0 FAM75 family PdaC PF13739.6 ETO02328.1 - 8.4 7.5 7.7 1.2e+03 0.5 7.7 2.6 1 1 0 1 1 1 0 Deacetylase PdaC NapE PF06796.11 ETO02329.1 - 0.07 12.7 0.3 0.72 9.4 0.1 2.3 2 0 0 2 2 2 0 Periplasmic nitrate reductase protein NapE Mpp10 PF04006.12 ETO02330.1 - 0.079 11.4 43.7 0.084 11.3 43.7 1.0 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 ETO02330.1 - 0.089 11.0 45.9 0.092 10.9 45.9 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO02330.1 - 0.46 8.7 36.2 0.55 8.5 36.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO02330.1 - 0.78 9.1 48.6 0.85 9.0 48.6 1.1 1 0 0 1 1 1 0 SDA1 DUF4746 PF15928.5 ETO02330.1 - 1.5 8.2 38.7 1.8 7.9 38.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_polI_A34 PF08208.11 ETO02330.1 - 1.5 8.8 37.8 1.8 8.6 37.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Vfa1 PF08432.10 ETO02330.1 - 2.2 8.6 32.1 3 8.2 32.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NPR3 PF03666.13 ETO02330.1 - 3.8 6.2 23.6 4 6.1 23.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SAPS PF04499.15 ETO02330.1 - 6.3 5.5 27.5 7.3 5.2 27.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 ETO02330.1 - 6.9 5.9 40.5 7.6 5.8 40.5 1.1 1 0 0 1 1 1 0 BUD22 DDRGK PF09756.9 ETO02330.1 - 7.3 6.1 40.0 10 5.7 40.0 1.4 1 0 0 1 1 1 0 DDRGK domain Zip PF02535.22 ETO02330.1 - 7.4 5.7 20.0 8.1 5.6 20.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TERB2 PF15101.6 ETO02330.1 - 8.2 6.4 18.0 10 6.1 18.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RP-C_C PF11800.8 ETO02330.1 - 9.4 6.3 19.9 11 6.1 19.9 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region CAP_GLY PF01302.25 ETO02331.1 - 0.00042 20.3 0.5 0.0025 17.8 0.5 2.4 1 1 0 1 1 1 1 CAP-Gly domain TFIIA PF03153.13 ETO02334.1 - 0.016 15.2 10.4 0.014 15.4 10.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ANAPC_CDC26 PF10471.9 ETO02334.1 - 0.021 15.7 14.2 0.032 15.1 14.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 Spt20 PF12090.8 ETO02334.1 - 0.045 13.4 19.4 0.059 13.0 19.4 1.3 1 0 0 1 1 1 0 Spt20 family Presenilin PF01080.17 ETO02334.1 - 0.56 8.9 4.0 0.49 9.1 4.0 1.1 1 0 0 1 1 1 0 Presenilin Ndc1_Nup PF09531.10 ETO02334.1 - 0.87 8.2 6.2 0.87 8.2 6.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup UPF0560 PF10577.9 ETO02334.1 - 1.9 6.9 10.1 2.1 6.7 10.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4175 PF13779.6 ETO02334.1 - 3.3 5.5 12.1 3.2 5.6 12.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Androgen_recep PF02166.16 ETO02334.1 - 8.3 5.1 16.4 9.7 4.9 16.4 1.1 1 0 0 1 1 1 0 Androgen receptor DUF4834 PF16118.5 ETO02334.1 - 9 7.3 12.1 3.4 8.7 9.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TPR_12 PF13424.6 ETO02335.1 - 2.5e-15 56.5 0.7 1e-08 35.3 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02335.1 - 4.4e-09 35.9 0.0 1.9e-06 27.5 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02335.1 - 5.6e-09 35.5 5.8 4.3e-07 29.6 1.5 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02335.1 - 4e-08 32.7 1.7 1.6e-07 30.9 1.7 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02335.1 - 6.9e-08 32.0 1.2 6.5e-06 25.9 0.7 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02335.1 - 5.5e-06 26.0 1.5 0.00014 21.5 1.5 2.7 1 1 0 1 1 1 1 TPR repeat TPR_7 PF13176.6 ETO02335.1 - 2e-05 24.3 0.4 9.8e-05 22.1 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO02335.1 - 0.00056 19.8 2.5 0.0016 18.4 2.5 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat eIF3g PF12353.8 ETO02335.1 - 0.023 15.1 2.5 0.026 14.9 1.1 1.8 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G TPR_6 PF13174.6 ETO02335.1 - 0.034 14.8 0.2 0.16 12.7 0.2 2.1 2 0 0 2 2 1 0 Tetratricopeptide repeat Fer4_12 PF13353.6 ETO02335.1 - 0.076 13.3 0.0 0.2 12.0 0.0 1.8 1 0 0 1 1 1 0 4Fe-4S single cluster domain TPR_16 PF13432.6 ETO02335.1 - 0.12 13.0 0.1 0.58 10.8 0.0 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF627 PF04781.12 ETO02335.1 - 0.14 12.2 1.2 0.35 10.9 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF627) MMR_HSR1 PF01926.23 ETO02336.1 - 0.0026 17.8 0.1 0.0051 16.9 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF1382 PF07131.11 ETO02336.1 - 0.087 12.8 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1382) RuvX PF03652.15 ETO02336.1 - 0.089 13.2 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 Holliday junction resolvase ETRAMP PF09716.10 ETO02336.1 - 5.4 7.1 8.8 4.6 7.4 5.4 2.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) NACHT PF05729.12 ETO02337.1 - 1.2e-10 41.5 0.0 2.6e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO02337.1 - 3.8e-05 24.0 0.2 0.00024 21.4 0.1 2.4 1 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO02337.1 - 0.0001 22.8 1.7 0.00037 21.0 0.0 2.7 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ETO02337.1 - 0.0036 17.3 0.1 0.065 13.2 0.0 2.5 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETO02337.1 - 0.018 15.5 0.9 0.049 14.1 0.0 2.2 2 1 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 ETO02337.1 - 0.019 15.3 1.9 0.046 14.1 0.0 2.4 2 1 0 2 2 2 0 RNA helicase RsgA_GTPase PF03193.16 ETO02337.1 - 0.039 13.8 1.8 0.17 11.7 0.1 2.7 2 1 1 3 3 3 0 RsgA GTPase AAA PF00004.29 ETO02337.1 - 0.048 14.1 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PRK PF00485.18 ETO02337.1 - 0.065 13.0 0.2 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATP_bind_2 PF03668.15 ETO02337.1 - 0.072 12.4 0.0 0.14 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family AAA_16 PF13191.6 ETO02337.1 - 0.098 13.0 0.3 0.9 9.9 0.0 2.5 1 1 2 3 3 3 0 AAA ATPase domain AAA_5 PF07728.14 ETO02337.1 - 0.14 12.2 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) PRP1_N PF06424.12 ETO02337.1 - 3.9 7.9 7.9 0.69 10.3 3.4 2.0 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal TPR_12 PF13424.6 ETO02338.1 - 1.3e-20 73.4 0.6 1.6e-12 47.6 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02338.1 - 4.9e-15 54.8 0.0 3.4e-06 26.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02338.1 - 1.6e-12 46.5 0.3 8.9e-07 28.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02338.1 - 8.8e-11 41.2 11.7 4.1e-07 29.6 0.4 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02338.1 - 1.2e-10 40.7 9.5 2.1e-06 27.5 0.9 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02338.1 - 4e-10 39.0 4.7 0.00023 21.0 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02338.1 - 5.4e-05 23.3 4.8 0.74 10.3 0.7 3.8 3 2 0 3 3 3 3 Tetratricopeptide repeat DUF840 PF05801.11 ETO02338.1 - 0.15 12.1 1.6 0.21 11.7 0.6 1.7 1 1 1 2 2 2 0 Lagovirus protein of unknown function (DUF840) LRR_8 PF13855.6 ETO02339.1 - 5.8e-08 32.4 12.2 1.6e-05 24.5 5.6 3.0 2 1 1 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ETO02339.1 - 3.2e-05 24.2 12.6 0.12 12.8 2.1 3.4 2 1 2 4 4 4 4 Leucine Rich repeats (2 copies) TRCF PF03461.15 ETO02339.1 - 0.11 12.9 3.9 3.3 8.2 0.1 3.2 1 1 2 3 3 3 0 TRCF domain LRR_1 PF00560.33 ETO02339.1 - 0.17 12.6 9.7 52 5.0 0.2 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat SpoVIF PF14069.6 ETO02340.1 - 0.013 15.3 0.1 3.2 7.6 0.0 2.5 1 1 1 2 2 2 0 Stage VI sporulation protein F Exonuc_VII_L PF02601.15 ETO02340.1 - 0.053 13.1 0.8 0.052 13.1 0.8 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit PIN_12 PF16289.5 ETO02340.1 - 0.22 12.0 4.3 0.29 11.6 4.3 1.2 1 0 0 1 1 1 0 PIN domain DUF2499 PF10693.9 ETO02341.1 - 0.039 14.2 0.6 0.5 10.7 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2499) Lactamase_B PF00753.27 ETO02342.1 - 5.5e-17 62.4 0.1 7.7e-17 62.0 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 ETO02342.1 - 4.8e-13 48.9 0.0 1e-12 47.8 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 ETO02342.1 - 4.5e-07 29.6 0.0 7e-07 29.0 0.0 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_6 PF16661.5 ETO02342.1 - 0.019 14.4 0.0 0.048 13.1 0.0 1.7 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily domain UN_NPL4 PF11543.8 ETO02342.1 - 0.088 13.3 0.0 0.22 12.1 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 Myosin_head PF00063.21 ETO02343.1 - 6.7e-118 394.7 8.4 4e-79 266.6 1.8 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) RicinB_lectin_2 PF14200.6 ETO02344.1 - 0.04 14.7 0.0 0.74 10.6 0.0 2.7 2 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain-like Phosphoprotein PF00922.17 ETO02345.1 - 0.028 14.0 1.6 0.049 13.2 1.6 1.4 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein CENP-B_dimeris PF09026.10 ETO02345.1 - 6.8 7.2 10.4 18 5.8 10.4 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CPSF100_C PF13299.6 ETO02345.1 - 9.4 6.4 6.4 3.5 7.8 3.1 1.8 1 1 1 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal zf-TRAF PF02176.18 ETO02346.1 - 4.7e-06 27.2 1.2 4.7e-06 27.2 1.2 2.9 2 1 0 2 2 2 1 TRAF-type zinc finger EMP24_GP25L PF01105.24 ETO02346.1 - 0.0025 17.8 0.9 0.0048 16.9 0.9 1.5 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD YabA PF06156.13 ETO02346.1 - 0.0043 17.6 5.9 0.015 15.9 5.9 1.9 1 0 0 1 1 1 1 Initiation control protein YabA DivIC PF04977.15 ETO02346.1 - 0.0063 16.3 4.8 0.0063 16.3 4.8 1.9 2 0 0 2 2 2 1 Septum formation initiator TSC22 PF01166.18 ETO02346.1 - 0.0078 16.5 4.2 0.023 15.0 3.1 2.3 2 0 0 2 2 2 1 TSC-22/dip/bun family DUF812 PF05667.11 ETO02346.1 - 0.012 14.5 5.6 0.021 13.7 5.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) ZapB PF06005.12 ETO02346.1 - 0.016 15.6 6.5 0.016 15.6 6.5 2.3 3 0 0 3 3 2 0 Cell division protein ZapB Herpes_BLRF2 PF05812.12 ETO02346.1 - 0.018 15.2 0.4 0.018 15.2 0.4 1.7 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein FlaC_arch PF05377.11 ETO02346.1 - 0.025 14.9 3.8 0.078 13.4 3.8 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) CENP-F_leu_zip PF10473.9 ETO02346.1 - 0.03 14.3 7.8 0.03 14.3 7.8 2.5 3 0 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 bZIP_1 PF00170.21 ETO02346.1 - 0.034 14.2 2.8 0.034 14.2 2.8 2.3 2 0 0 2 2 2 0 bZIP transcription factor Spc24 PF08286.11 ETO02346.1 - 0.046 14.0 2.0 0.12 12.6 2.0 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Mto2_bdg PF12808.7 ETO02346.1 - 0.22 11.9 2.4 0.63 10.4 2.4 1.8 1 0 0 1 1 1 0 Micro-tubular organiser Mto1 C-term Mto2-binding region UPF0242 PF06785.11 ETO02346.1 - 0.22 11.6 11.6 5.8 7.0 12.6 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Seryl_tRNA_N PF02403.22 ETO02346.1 - 0.29 11.4 6.7 0.12 12.6 3.5 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain GIT_CC PF16559.5 ETO02346.1 - 0.67 9.9 9.0 0.31 11.0 5.4 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Amb_V_allergen PF03913.13 ETO02347.1 - 0.1 12.5 0.7 0.2 11.6 0.7 1.4 1 0 0 1 1 1 0 Amb V Allergen MRP-S23 PF10484.9 ETO02347.1 - 0.61 10.4 3.8 0.4 10.9 0.6 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal protein S23 Pneumo_M2 PF07380.11 ETO02349.1 - 0.053 13.8 1.2 0.053 13.8 1.2 2.3 2 1 0 2 2 2 0 Pneumovirus M2 protein Kelch_4 PF13418.6 ETO02350.1 - 0.0077 16.2 0.1 0.017 15.1 0.1 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO02350.1 - 0.015 15.6 0.0 0.027 14.8 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO02350.1 - 0.16 12.3 0.3 0.65 10.4 0.2 2.0 2 0 0 2 2 2 0 Kelch motif DUF739 PF05339.11 ETO02351.1 - 0.037 14.2 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF739) RPEL PF02755.15 ETO02351.1 - 1.3 8.8 94.5 0.21 11.4 0.7 17.3 20 0 0 20 20 20 0 RPEL repeat tRNA-synt_1c PF00749.21 ETO02354.1 - 0.03 13.2 0.2 0.032 13.1 0.2 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain DUF2222 PF09984.9 ETO02354.1 - 0.093 12.6 1.7 0.11 12.4 1.4 1.3 1 1 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) Phasin_2 PF09361.10 ETO02355.1 - 0.039 14.2 0.5 0.34 11.2 0.1 2.3 2 1 0 2 2 2 0 Phasin protein DUF4937 PF16291.5 ETO02356.1 - 0.025 14.8 0.6 0.032 14.5 0.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4937 TMEM51 PF15345.6 ETO02356.1 - 6 6.6 9.7 8.1 6.2 9.7 1.2 1 1 0 1 1 1 0 Transmembrane protein 51 Pkinase PF00069.25 ETO02357.1 - 7.9e-09 35.3 0.0 9.5e-09 35.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO02357.1 - 0.0005 19.4 0.0 0.0006 19.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase SPO22 PF08631.10 ETO02358.1 - 0.022 14.3 0.2 0.026 14.0 0.2 1.1 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Kelch_4 PF13418.6 ETO02360.1 - 4.4e-08 33.0 0.0 0.0063 16.5 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO02360.1 - 4.6e-08 32.5 1.3 0.00051 19.6 0.4 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO02360.1 - 6e-07 29.3 0.6 0.047 13.7 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO02360.1 - 1.1e-06 28.8 0.1 0.0017 18.6 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO02360.1 - 2e-06 27.5 0.4 0.0011 18.8 0.3 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO02360.1 - 7.9e-06 26.0 1.5 0.056 13.7 0.6 2.6 1 1 1 2 2 2 2 Kelch motif tRNA_Me_trans PF03054.16 ETO02360.1 - 0.11 11.2 0.0 0.15 10.8 0.0 1.1 1 0 0 1 1 1 0 tRNA methyl transferase HECT PF00632.25 ETO02361.1 - 3.3e-16 59.6 0.0 3.8e-16 59.5 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TLD PF07534.16 ETO02362.1 - 0.042 14.1 0.5 0.68 10.1 0.1 2.7 2 1 0 2 2 2 0 TLD Tropomyosin_1 PF12718.7 ETO02364.1 - 0.0046 17.1 11.2 0.0046 17.1 4.2 2.4 1 1 1 2 2 2 1 Tropomyosin like TIP_N PF12457.8 ETO02364.1 - 0.029 14.7 1.5 0.046 14.1 1.5 1.4 1 0 0 1 1 1 0 Tuftelin interacting protein N terminal Fib_alpha PF08702.10 ETO02364.1 - 0.16 12.1 10.5 0.061 13.5 2.7 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family PI-TkoII_IV PF18714.1 ETO02365.1 - 0.13 11.8 0.0 0.24 10.9 0.0 1.4 1 0 0 1 1 1 0 DNA polymerase II intein Domain IV Tcf25 PF04910.14 ETO02366.1 - 8.9e-55 186.2 2.7 2.6e-54 184.6 2.7 1.8 1 0 0 1 1 1 1 Transcriptional repressor TCF25 betaPIX_CC PF16523.5 ETO02368.1 - 0.0054 16.5 7.9 0.0054 16.5 7.9 1.4 1 1 0 1 1 1 1 betaPIX coiled coil Mto2_bdg PF12808.7 ETO02368.1 - 0.016 15.5 3.5 0.016 15.5 3.5 1.7 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUSP PF06337.12 ETO02368.1 - 0.061 14.0 1.8 0.072 13.7 1.8 1.2 1 0 0 1 1 1 0 DUSP domain Ax_dynein_light PF10211.9 ETO02368.1 - 0.089 12.7 11.7 0.11 12.4 11.7 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain GrpE PF01025.19 ETO02368.1 - 0.26 11.0 9.7 0.28 10.8 9.7 1.1 1 0 0 1 1 1 0 GrpE MCC-bdg_PDZ PF10506.9 ETO02368.1 - 0.27 11.3 5.7 0.13 12.3 3.4 1.6 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF4140 PF13600.6 ETO02368.1 - 0.45 11.0 3.0 0.6 10.6 3.0 1.2 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) TcdB_N PF12918.7 ETO02368.1 - 0.73 10.2 12.7 0.62 10.4 7.0 2.4 1 1 1 2 2 2 0 TcdB toxin N-terminal helical domain CLN3 PF02487.17 ETO02368.1 - 2 7.4 5.8 2.3 7.2 5.8 1.0 1 0 0 1 1 1 0 CLN3 protein LAGLIDADG_1 PF00961.19 ETO02368.1 - 2.3 9.3 9.1 22 6.1 9.1 2.0 1 1 0 1 1 1 0 LAGLIDADG endonuclease TMPIT PF07851.13 ETO02368.1 - 2.3 7.4 8.3 2.5 7.3 8.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein LMBR1 PF04791.16 ETO02368.1 - 3.5 6.4 6.8 3.7 6.4 6.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 ETO02370.1 - 4e-73 239.5 23.5 1.4e-11 44.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02370.1 - 1.7e-32 111.6 0.8 0.00031 21.0 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02370.1 - 1.6e-14 53.9 0.0 0.00036 20.0 0.0 4.4 1 1 3 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO02370.1 - 8.5e-12 44.7 0.2 0.22 10.4 0.0 5.8 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO02370.1 - 1.2e-08 34.7 3.3 13 5.9 0.0 6.8 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO02370.1 - 6.7e-08 31.6 1.9 0.17 10.5 0.0 5.4 1 1 4 5 5 5 2 Nucleoporin Nup120/160 DUF727 PF05303.12 ETO02370.1 - 1.7e-06 28.0 0.1 3.7 7.7 0.0 5.6 1 1 5 6 6 6 1 Protein of unknown function (DUF727) DUF5570 PF17731.1 ETO02370.1 - 4.8e-06 26.7 10.1 0.78 9.8 0.1 5.5 1 1 5 6 6 6 2 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO02370.1 - 2.8e-05 23.7 9.3 12 5.7 0.0 6.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature BBS2_Mid PF14783.6 ETO02370.1 - 3.4e-05 23.8 0.9 3 7.9 0.1 5.3 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.6 ETO02370.1 - 4.5e-05 23.2 0.5 0.0021 17.7 0.5 2.9 1 1 0 1 1 1 1 PQQ-like domain Gmad1 PF10647.9 ETO02370.1 - 5.9e-05 22.9 0.0 0.37 10.5 0.0 4.1 1 1 2 4 4 4 2 Lipoprotein LpqB beta-propeller domain Pentapeptide PF00805.22 ETO02370.1 - 0.00013 21.5 3.5 0.002 17.7 0.3 2.1 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) Rpn3_C PF08375.11 ETO02370.1 - 0.00073 19.9 0.0 2 8.9 0.0 4.5 5 0 0 5 5 5 1 Proteasome regulatory subunit C-terminal Cytochrom_D1 PF02239.16 ETO02370.1 - 0.0014 17.2 0.3 0.44 9.0 0.1 2.8 1 1 2 3 3 3 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO02370.1 - 0.0016 17.9 3.5 0.72 9.1 0.3 3.7 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 ETO02370.1 - 0.002 16.5 0.0 3.6 5.8 0.0 3.9 1 1 2 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz HARP PF07443.13 ETO02370.1 - 0.011 15.3 0.0 0.47 10.1 0.0 3.4 5 0 0 5 5 5 0 HepA-related protein (HARP) DPPIV_N PF00930.21 ETO02370.1 - 0.015 14.1 0.2 50 2.5 0.0 4.3 2 2 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region TolB_N PF04052.13 ETO02370.1 - 0.02 15.1 0.0 1.4e+02 2.7 0.0 5.3 6 0 0 6 6 6 0 TolB amino-terminal domain Pentapeptide_4 PF13599.6 ETO02370.1 - 0.024 14.8 0.4 0.053 13.7 0.4 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Reg_prop PF07494.11 ETO02370.1 - 0.049 13.9 1.0 50 4.6 0.0 4.8 5 0 0 5 5 5 0 Two component regulator propeller Peptidase_S29 PF02907.15 ETO02370.1 - 0.74 9.5 4.5 76 3.0 0.1 4.1 2 1 2 4 4 4 0 Hepatitis C virus NS3 protease DUF5122 PF17164.4 ETO02370.1 - 3.2 8.1 5.4 15 5.9 0.1 3.9 5 0 0 5 5 4 0 Domain of unknown function (DUF5122) beta-propeller WD40 PF00400.32 ETO02374.1 - 0.027 15.3 1.4 0.036 14.9 0.6 1.7 2 0 0 2 2 2 0 WD domain, G-beta repeat SesA PF17107.5 ETO02375.1 - 0.029 14.6 0.0 0.047 13.9 0.0 1.3 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases HSP90 PF00183.18 ETO02376.1 - 1.1e-49 169.7 5.8 1.4e-49 169.4 5.8 1.0 1 0 0 1 1 1 1 Hsp90 protein DUF2680 PF10925.8 ETO02376.1 - 0.042 13.8 0.0 0.085 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2680) HSP90 PF00183.18 ETO02377.1 - 4.2e-30 105.1 0.4 1.1e-29 103.8 0.4 1.6 1 1 0 1 1 1 1 Hsp90 protein Kelch_4 PF13418.6 ETO02378.1 - 0.0026 17.7 0.2 0.73 9.9 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO02378.1 - 0.053 13.5 0.7 0.92 9.6 0.1 2.3 1 1 1 2 2 2 0 Kelch motif WD40 PF00400.32 ETO02379.1 - 2.9e-31 107.0 27.0 7e-06 26.7 0.1 7.9 7 2 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO02379.1 - 7.3e-08 31.5 8.2 0.019 13.6 0.0 4.4 2 1 3 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02379.1 - 3.1e-06 27.4 3.0 0.44 10.9 0.0 5.2 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO02379.1 - 4.3e-06 25.8 6.2 7.6e-05 21.6 2.5 2.4 2 1 0 2 2 2 2 Nup133 N terminal like BBS2_Mid PF14783.6 ETO02379.1 - 0.00037 20.5 4.8 0.15 12.2 0.2 4.1 3 2 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region CSG2 PF16965.5 ETO02380.1 - 0.0058 15.6 0.6 0.0069 15.4 0.6 1.2 1 0 0 1 1 1 1 Ceramide synthase regulator ORC_WH_C PF18137.1 ETO02380.1 - 0.027 14.5 1.6 0.037 14.1 1.6 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Zip PF02535.22 ETO02380.1 - 0.072 12.3 0.0 0.076 12.2 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 ETO02380.1 - 0.46 10.2 8.8 0.71 9.6 8.8 1.4 1 1 0 1 1 1 0 Connexin AP3D1 PF06375.11 ETO02380.1 - 1.4 9.1 14.7 1.9 8.7 14.7 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4834 PF16118.5 ETO02380.1 - 1.6 9.8 10.8 0.51 11.3 7.6 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) Orf78 PF06024.12 ETO02380.1 - 8.7 6.7 11.6 0.41 11.0 0.2 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Ecm33 PF12454.8 ETO02381.1 - 0.1 12.8 0.1 0.26 11.5 0.1 1.7 1 0 0 1 1 1 0 GPI-anchored cell wall organization protein Dus PF01207.17 ETO02382.1 - 4e-45 154.3 0.4 4.3e-45 154.1 0.4 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ETO02382.1 - 0.00016 21.2 0.0 0.0005 19.6 0.0 1.6 1 1 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 ETO02382.1 - 0.011 15.0 0.0 0.017 14.5 0.0 1.3 1 0 0 1 1 1 0 Thiamine monophosphate synthase BKACE PF05853.12 ETO02382.1 - 0.059 12.7 0.0 0.073 12.4 0.0 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme DHO_dh PF01180.21 ETO02382.1 - 0.086 12.0 0.0 2.3 7.3 0.0 2.1 1 1 0 1 1 1 0 Dihydroorotate dehydrogenase V-ATPase_C PF03223.15 ETO02383.1 - 0.064 12.6 0.8 0.085 12.2 0.8 1.2 1 0 0 1 1 1 0 V-ATPase subunit C Cys_rich_VLP PF14194.6 ETO02384.1 - 0.091 12.9 3.6 0.31 11.2 0.5 2.2 2 0 0 2 2 2 0 Cysteine-rich VLP Cpn60_TCP1 PF00118.24 ETO02385.1 - 1.3e-28 99.9 0.2 2.5e-24 85.8 0.0 2.3 1 1 1 2 2 2 2 TCP-1/cpn60 chaperonin family RsbU_N PF08673.10 ETO02386.1 - 0.037 14.1 0.1 0.18 11.9 0.1 2.3 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain DUF3445 PF11927.8 ETO02387.1 - 0.0065 16.1 1.7 3.2 7.3 0.1 2.9 1 1 2 3 3 3 2 Protein of unknown function (DUF3445) GTP_CH_N PF12471.8 ETO02387.1 - 0.17 11.6 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 GTP cyclohydrolase N terminal CAP_GLY PF01302.25 ETO02388.1 - 2e-05 24.5 1.4 0.00054 19.9 0.1 2.4 2 0 0 2 2 2 2 CAP-Gly domain Sigma70_ner PF04546.13 ETO02389.1 - 6.2e-05 23.0 0.4 7.6e-05 22.7 0.4 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region Sporozoite_P67 PF05642.11 ETO02389.1 - 0.00027 19.2 0.9 0.00033 18.9 0.9 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen SDA1 PF05285.12 ETO02389.1 - 0.0039 16.7 5.6 0.0043 16.5 5.6 1.1 1 0 0 1 1 1 1 SDA1 FAM176 PF14851.6 ETO02389.1 - 0.011 15.4 1.9 0.02 14.5 1.9 1.5 1 0 0 1 1 1 0 FAM176 family FAM60A PF15396.6 ETO02389.1 - 0.012 15.7 0.1 0.016 15.3 0.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4611 PF15387.6 ETO02389.1 - 0.015 15.5 7.9 0.027 14.7 7.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Connexin PF00029.19 ETO02389.1 - 0.027 14.2 0.0 0.037 13.8 0.0 1.2 1 0 0 1 1 1 0 Connexin DUF2722 PF10846.8 ETO02389.1 - 0.03 13.3 2.6 0.032 13.2 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TRAP_alpha PF03896.16 ETO02389.1 - 0.049 12.8 2.4 0.07 12.3 2.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tim54 PF11711.8 ETO02389.1 - 0.088 11.6 1.9 0.11 11.2 1.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 YqfQ PF14181.6 ETO02389.1 - 0.11 12.7 1.5 0.15 12.3 1.5 1.2 1 0 0 1 1 1 0 YqfQ-like protein CDC45 PF02724.14 ETO02389.1 - 0.13 10.5 10.3 0.18 10.0 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO02389.1 - 0.14 12.2 14.0 0.19 11.8 14.0 1.1 1 0 0 1 1 1 0 YL1 nuclear protein PI3K_1B_p101 PF10486.9 ETO02389.1 - 0.26 9.0 1.2 0.32 8.7 1.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PBP1_TM PF14812.6 ETO02389.1 - 0.28 11.6 15.5 0.53 10.7 15.5 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFB6 PF17110.5 ETO02389.1 - 0.39 10.5 5.8 0.61 9.8 5.8 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF5520 PF17658.1 ETO02389.1 - 0.42 9.7 5.0 0.55 9.3 5.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) SGT1 PF07093.11 ETO02389.1 - 0.47 8.8 10.2 0.67 8.3 10.2 1.1 1 0 0 1 1 1 0 SGT1 protein CobT PF06213.12 ETO02389.1 - 0.5 9.7 9.2 0.66 9.3 9.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Cnd2 PF05786.14 ETO02389.1 - 0.6 8.7 9.9 0.8 8.3 9.9 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 RXT2_N PF08595.11 ETO02389.1 - 0.61 10.1 7.2 0.99 9.4 7.2 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.11 ETO02389.1 - 0.65 8.5 7.4 0.86 8.1 7.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 ETO02389.1 - 0.76 7.9 12.4 0.95 7.6 12.4 1.0 1 0 0 1 1 1 0 Nop14-like family TLP-20 PF06088.11 ETO02389.1 - 1.3 8.9 8.9 2 8.3 8.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RNA_polI_A34 PF08208.11 ETO02389.1 - 1.4 9.0 9.3 2.4 8.2 9.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NOA36 PF06524.12 ETO02389.1 - 1.6 7.9 19.6 2.2 7.5 19.6 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 ETO02389.1 - 2.2 7.3 19.5 3 6.9 19.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TFIIF_alpha PF05793.12 ETO02389.1 - 2.8 6.4 15.8 3.8 6.0 15.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GEN1_C PF18380.1 ETO02389.1 - 3.5 8.6 8.6 6.9 7.6 8.6 1.4 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain RPN2_C PF18004.1 ETO02389.1 - 4.8 7.1 9.4 7 6.5 9.4 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pox_Ag35 PF03286.14 ETO02389.1 - 5.7 6.7 11.2 7.9 6.2 11.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO02389.1 - 8.7 4.3 19.7 11 3.9 19.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF5549 PF17703.1 ETO02390.1 - 0.009 15.7 0.2 0.012 15.3 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5549) Glycophorin_A PF01102.18 ETO02390.1 - 0.073 13.3 5.3 0.13 12.5 5.3 1.4 1 0 0 1 1 1 0 Glycophorin A Dicty_REP PF05086.12 ETO02390.1 - 0.11 10.5 12.6 0.11 10.4 12.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ABG_transport PF03806.13 ETO02390.1 - 0.29 9.3 0.0 0.33 9.1 0.0 1.0 1 0 0 1 1 1 0 AbgT putative transporter family AJAP1_PANP_C PF15298.6 ETO02390.1 - 0.4 10.9 15.6 0.55 10.4 15.6 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF3484 PF11983.8 ETO02390.1 - 0.55 11.4 3.0 0.84 10.8 2.2 1.6 1 1 1 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Mucin PF01456.17 ETO02390.1 - 0.58 10.1 29.4 0.89 9.5 29.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Presenilin PF01080.17 ETO02390.1 - 0.7 8.6 3.9 0.8 8.4 3.9 1.1 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO02390.1 - 0.8 8.0 7.0 0.95 7.7 7.0 1.1 1 0 0 1 1 1 0 Menin DUF5320 PF17253.2 ETO02390.1 - 0.87 10.7 11.0 0.43 11.7 8.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5320) TMEM154 PF15102.6 ETO02390.1 - 7 6.6 13.4 10 6.1 13.4 1.4 1 0 0 1 1 1 0 TMEM154 protein family LmjF365940-deam PF14421.6 ETO02391.1 - 2.5e-29 102.3 0.0 2.9e-29 102.1 0.0 1.1 1 0 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.23 ETO02391.1 - 0.065 13.1 0.0 0.089 12.7 0.0 1.2 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF641 PF04859.12 ETO02393.1 - 0.023 15.1 3.7 0.023 15.1 3.7 2.8 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) HAP1_N PF04849.13 ETO02393.1 - 0.028 13.7 23.7 0.22 10.7 12.5 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region Fib_alpha PF08702.10 ETO02393.1 - 0.81 9.9 26.4 3.5 7.8 9.7 2.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF16 PF01519.16 ETO02393.1 - 1 9.9 24.3 4.8 7.7 10.8 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 THOC7 PF05615.13 ETO02393.1 - 1.2 9.4 20.9 1.8 8.8 14.0 2.8 1 1 1 2 2 2 0 Tho complex subunit 7 DUF1818 PF08848.11 ETO02393.1 - 1.4 9.0 12.5 1.6 8.8 2.8 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF1818) LPP PF04728.13 ETO02393.1 - 3.1 8.3 12.8 8.9 6.8 0.6 4.1 3 1 1 4 4 4 0 Lipoprotein leucine-zipper zf-C3HC4_3 PF13920.6 ETO02393.1 - 3.3 7.7 8.8 15 5.6 8.8 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TMF_TATA_bd PF12325.8 ETO02393.1 - 3.7 7.8 20.7 0.071 13.3 6.2 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF848 PF05852.11 ETO02393.1 - 4 7.5 13.3 0.76 9.9 7.9 2.4 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) YlqD PF11068.8 ETO02393.1 - 8.5 6.8 25.7 7.6 6.9 20.9 2.8 1 1 1 2 2 2 0 YlqD protein WD40 PF00400.32 ETO02395.1 - 1.5e-24 85.8 14.6 1e-05 26.2 0.1 5.7 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02395.1 - 4.9e-07 30.0 0.8 0.31 11.4 0.0 4.1 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02395.1 - 2.8e-05 23.0 0.6 0.086 11.5 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 P2 PF07194.11 ETO02397.1 - 0.025 14.6 0.2 0.049 13.7 0.1 1.7 1 1 1 2 2 2 0 P2 response regulator binding domain RPA_interact_M PF14767.6 ETO02398.1 - 0.043 14.4 0.3 3.9 8.1 0.1 2.5 3 0 0 3 3 3 0 Replication protein A interacting middle PIN_5 PF08745.11 ETO02398.1 - 0.062 12.7 0.2 0.34 10.3 0.0 2.2 2 1 0 2 2 2 0 PINc domain ribonuclease AAA_22 PF13401.6 ETO02399.1 - 2.3e-05 24.7 0.1 0.0009 19.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO02399.1 - 2.5e-05 24.8 0.1 0.00015 22.3 0.0 2.0 2 0 0 2 2 2 1 ABC transporter AAA_8 PF12780.7 ETO02399.1 - 3.6e-05 23.2 0.2 9.4e-05 21.8 0.0 1.7 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_5 PF07728.14 ETO02399.1 - 5.2e-05 23.3 0.0 9.8e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO02399.1 - 9.3e-05 22.0 0.0 0.00021 20.9 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO02399.1 - 0.00027 21.3 0.0 0.00074 19.9 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 ETO02399.1 - 0.0013 17.9 0.1 0.0038 16.4 0.0 1.6 1 1 1 2 2 2 1 MCM P-loop domain RNA_helicase PF00910.22 ETO02399.1 - 0.0021 18.4 0.1 0.038 14.4 0.0 2.3 2 0 0 2 2 2 1 RNA helicase TsaE PF02367.17 ETO02399.1 - 0.0092 16.0 0.1 0.017 15.1 0.0 1.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETO02399.1 - 0.013 15.9 0.0 0.021 15.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ETO02399.1 - 0.016 15.1 0.1 0.03 14.2 0.1 1.5 1 1 0 1 1 1 0 RsgA GTPase Sigma54_activat PF00158.26 ETO02399.1 - 0.02 14.6 0.0 0.032 13.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 ETO02399.1 - 0.021 14.0 0.2 0.066 12.4 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 ETO02399.1 - 0.034 14.1 0.1 0.068 13.1 0.1 1.5 1 0 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 ETO02399.1 - 0.058 13.9 0.1 0.55 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ETO02399.1 - 0.063 13.2 0.1 0.063 13.2 0.1 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_23 PF13476.6 ETO02399.1 - 0.1 13.1 0.3 0.1 13.1 0.3 2.2 1 1 1 2 2 2 0 AAA domain T2SSE PF00437.20 ETO02399.1 - 0.19 10.7 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 ETO02399.1 - 0.59 10.2 4.0 3.1 7.8 0.0 2.4 1 1 1 2 2 2 0 AAA domain DUF4018 PF13210.6 ETO02400.1 - 0.086 12.6 2.1 0.13 12.0 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4018) Herpes_gE PF02480.16 ETO02400.1 - 0.15 10.7 6.9 0.2 10.3 6.5 1.3 1 1 0 1 1 1 0 Alphaherpesvirus glycoprotein E NuiA PF07924.11 ETO02401.1 - 0.076 13.4 0.1 0.14 12.6 0.1 1.4 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein DegT_DnrJ_EryC1 PF01041.17 ETO02402.1 - 0.071 12.4 1.3 0.082 12.2 1.3 1.1 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family Hydrolase_3 PF08282.12 ETO02402.1 - 0.65 9.7 4.6 0.75 9.5 4.6 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Peptidase_S46 PF10459.9 ETO02402.1 - 1.5 7.4 8.7 1.9 7.0 8.7 1.0 1 0 0 1 1 1 0 Peptidase S46 Kelch_4 PF13418.6 ETO02403.1 - 0.00014 21.8 0.1 0.0024 17.8 0.0 2.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO02403.1 - 0.017 14.7 0.1 0.064 12.9 0.1 2.0 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO02403.1 - 0.062 13.6 0.1 6 7.3 0.1 2.5 2 0 0 2 2 2 0 Kelch motif CLP_protease PF00574.23 ETO02403.1 - 0.13 12.1 1.0 0.2 11.5 1.0 1.2 1 0 0 1 1 1 0 Clp protease WD40 PF00400.32 ETO02404.1 - 8.6e-13 48.6 0.9 2.8e-05 24.8 0.2 3.0 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02404.1 - 0.0019 16.9 0.2 0.4 9.3 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02404.1 - 0.039 14.2 0.1 1.4 9.3 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Sigma_reg_N PF13800.6 ETO02405.1 - 0.048 14.0 0.2 0.048 14.0 0.2 4.5 4 1 2 6 6 6 0 Sigma factor regulator N-terminal Orthopox_A36R PF05950.11 ETO02406.1 - 0.33 11.1 1.4 0.52 10.5 0.2 1.8 1 1 1 2 2 2 0 Orthopoxvirus A36R protein TPR_12 PF13424.6 ETO02407.1 - 9.3e-44 147.6 0.6 4.3e-18 65.4 0.1 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02407.1 - 4.4e-31 105.9 0.0 1.6e-10 40.5 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02407.1 - 3.5e-23 80.4 4.4 6.5e-09 35.2 0.2 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02407.1 - 3.6e-23 79.8 0.1 6.8e-09 35.1 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02407.1 - 1.1e-17 62.7 8.5 5.2e-07 29.4 0.4 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02407.1 - 1.4e-12 46.7 1.9 0.00076 19.4 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02407.1 - 8.8e-11 41.4 4.2 0.00037 20.7 0.1 3.8 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02407.1 - 3.6e-08 33.9 0.0 0.014 16.1 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02407.1 - 5.8e-07 29.1 7.6 0.036 13.7 0.0 4.2 3 1 1 4 4 4 2 TPR repeat MIT PF04212.18 ETO02407.1 - 4.2e-06 26.7 5.0 0.014 15.4 0.1 3.1 1 1 2 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO02407.1 - 2.2e-05 24.9 0.0 2.8 9.0 0.0 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02407.1 - 6.7e-05 22.8 2.8 0.065 13.0 0.1 2.8 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO02407.1 - 0.00039 20.9 0.0 19 6.1 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat SNAP PF14938.6 ETO02407.1 - 0.0034 16.9 0.1 0.024 14.1 0.1 2.0 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETO02407.1 - 0.015 15.5 0.8 9.7 6.7 0.1 2.8 3 0 0 3 3 3 0 PPR repeat HTH_Bact PF18768.1 ETO02407.1 - 0.021 14.4 0.2 36 4.0 0.0 3.4 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain DUF4810 PF16068.5 ETO02407.1 - 0.037 14.6 0.5 7.2 7.2 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4810) Fis1_TPR_C PF14853.6 ETO02407.1 - 0.047 13.8 0.7 57 3.9 0.1 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF627 PF04781.12 ETO02407.1 - 0.083 12.9 0.1 0.98 9.5 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF627) Intimin_C PF07979.11 ETO02407.1 - 0.11 12.9 1.0 0.65 10.5 0.2 2.1 1 1 1 2 2 2 0 Intimin C-type lectin domain TPR_19 PF14559.6 ETO02407.1 - 0.12 12.9 0.0 8.9 6.9 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat Rota_NSP3 PF01665.16 ETO02407.1 - 0.18 10.9 1.5 23 4.0 0.1 2.8 1 1 2 3 3 3 0 Rotavirus non-structural protein NSP3 BAR_3 PF16746.5 ETO02407.1 - 0.23 11.1 0.8 10 5.7 0.1 2.2 1 1 1 2 2 2 0 BAR domain of APPL family MBOAT_2 PF13813.6 ETO02410.1 - 0.039 14.2 1.9 0.11 12.8 1.9 1.8 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family TPR_12 PF13424.6 ETO02411.1 - 4.3e-40 135.9 7.9 5.7e-19 68.2 0.8 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02411.1 - 4.5e-31 105.8 3.6 7.8e-09 35.1 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02411.1 - 4.5e-22 76.9 22.2 2.7e-08 33.3 0.6 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02411.1 - 5.7e-16 57.3 18.6 2.1e-05 24.4 0.5 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02411.1 - 9.4e-16 56.6 6.9 0.0003 20.6 0.0 3.4 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02411.1 - 5.1e-13 48.0 10.4 0.00065 19.6 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02411.1 - 6.9e-10 39.0 3.7 0.04 13.7 0.4 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETO02411.1 - 1.1e-06 28.6 11.4 0.086 13.3 0.2 4.6 5 2 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02411.1 - 2.5e-05 23.9 23.4 0.014 15.1 0.3 5.6 4 2 2 6 6 6 5 TPR repeat DUF357 PF04010.13 ETO02411.1 - 0.0004 20.4 4.4 0.16 12.1 0.1 3.0 1 1 2 3 3 3 2 Protein of unknown function (DUF357) TPR_14 PF13428.6 ETO02411.1 - 0.00091 19.9 0.0 11 7.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5475 PF17569.2 ETO02411.1 - 0.0025 18.1 0.4 6.9 7.1 0.0 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5475) Thg1 PF04446.12 ETO02411.1 - 0.0031 17.5 0.7 15 5.7 0.0 3.0 1 1 2 3 3 3 0 tRNAHis guanylyltransferase NSF PF02071.20 ETO02411.1 - 0.0034 17.8 4.0 24 6.3 0.1 4.1 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat WHAMM-JMY_N PF15920.5 ETO02411.1 - 0.0044 16.8 0.0 4.3 7.3 0.0 2.8 3 0 0 3 3 3 1 N-terminal of Junction-mediating and WASP homolog-associated Acetate_kinase PF00871.17 ETO02411.1 - 0.0065 15.2 1.6 1 8.0 0.1 2.8 1 1 2 3 3 3 2 Acetokinase family HTH_Bact PF18768.1 ETO02411.1 - 0.011 15.3 2.1 1.9 8.2 0.0 3.9 2 1 1 3 3 3 0 Helix-turn-helix bacterial domain Cation_ATPase PF13246.6 ETO02411.1 - 0.044 13.9 0.1 17 5.6 0.0 2.8 1 1 1 2 2 2 0 Cation transport ATPase (P-type) POR PF01558.18 ETO02411.1 - 0.083 13.0 0.3 35 4.4 0.0 2.7 1 1 2 3 3 3 0 Pyruvate ferredoxin/flavodoxin oxidoreductase Cytochrom_CIII PF02085.16 ETO02411.1 - 0.15 12.4 0.4 5.5 7.4 0.1 2.1 1 1 1 2 2 2 0 Class III cytochrome C family PLL PF18587.1 ETO02411.1 - 0.16 12.1 1.5 57 3.8 0.1 3.2 1 1 2 3 3 3 0 PTX/LNS-Like (PLL) domain TPR_MalT PF17874.1 ETO02411.1 - 0.18 11.1 0.0 0.2 11.0 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region SPO22 PF08631.10 ETO02411.1 - 0.2 11.1 2.2 7.2 6.0 0.1 2.0 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like NRBF2_MIT PF17169.4 ETO02411.1 - 0.22 11.8 3.2 12 6.2 0.1 2.8 2 1 1 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 Nudix_N PF12535.8 ETO02411.1 - 0.3 10.7 9.0 4.4 7.0 0.2 3.2 3 0 0 3 3 3 0 Hydrolase of X-linked nucleoside diphosphate N terminal TPR_3 PF07720.12 ETO02411.1 - 0.92 9.6 5.5 18 5.5 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat CDC45 PF02724.14 ETO02412.1 - 0.022 13.1 12.2 0.026 12.9 12.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 ETO02412.1 - 0.026 14.7 3.0 0.036 14.2 3.0 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO02412.1 - 0.13 11.0 10.5 0.19 10.5 10.5 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO02412.1 - 0.34 9.6 12.7 0.41 9.4 12.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO02412.1 - 0.41 9.8 7.3 0.53 9.4 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ASD2 PF08687.11 ETO02412.1 - 0.59 9.7 13.5 0.89 9.1 13.5 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Secretin_N_2 PF07655.13 ETO02412.1 - 0.63 10.6 10.8 1.7 9.3 10.8 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Pox_Ag35 PF03286.14 ETO02412.1 - 0.86 9.4 20.7 1.4 8.6 20.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SLC12 PF03522.15 ETO02412.1 - 1.5 7.8 11.7 2.1 7.3 11.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RP-C_C PF11800.8 ETO02412.1 - 1.6 8.8 6.5 2.3 8.2 6.5 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Neur_chan_memb PF02932.16 ETO02412.1 - 7 6.6 6.8 11 6.1 6.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PTPRCAP PF15713.5 ETO02412.1 - 7 6.9 18.1 12 6.2 18.1 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TMEM51 PF15345.6 ETO02413.1 - 0.49 10.2 3.6 0.47 10.3 3.6 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 PI3K_rbd PF00794.18 ETO02415.1 - 0.037 14.2 0.0 0.067 13.4 0.0 1.5 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain DUF3677 PF12432.8 ETO02415.1 - 0.044 14.1 0.1 0.075 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3677) Kelch_6 PF13964.6 ETO02417.1 - 0.084 13.2 0.1 1.2 9.5 0.0 2.6 3 0 0 3 3 3 0 Kelch motif FPP PF05911.11 ETO02418.1 - 0.0059 14.9 4.0 0.0059 14.9 4.0 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Geminin PF07412.12 ETO02418.1 - 0.014 15.1 2.8 0.014 15.1 2.8 2.0 2 0 0 2 2 2 0 Geminin DUF641 PF04859.12 ETO02418.1 - 0.036 14.4 1.4 0.036 14.4 1.4 1.5 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Flavokinase PF01687.17 ETO02418.1 - 0.068 13.5 0.7 0.081 13.2 0.7 1.3 1 1 0 1 1 1 0 Riboflavin kinase TMEM247 PF15444.6 ETO02419.1 - 0.083 12.9 3.1 0.13 12.3 3.1 1.4 1 1 0 1 1 1 0 Transmembrane protein 247 Inhibitor_I29 PF08246.12 ETO02420.1 - 4.2 7.9 9.7 1.9 9.0 3.0 2.4 2 0 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) ELMO_CED12 PF04727.13 ETO02421.1 - 0.053 13.6 0.5 0.082 13.0 0.2 1.5 2 0 0 2 2 2 0 ELMO/CED-12 family Presenilin PF01080.17 ETO02422.1 - 0.17 10.6 4.6 0.18 10.5 4.6 1.1 1 0 0 1 1 1 0 Presenilin MID_MedPIWI PF18296.1 ETO02422.1 - 0.23 11.2 9.1 0.3 10.8 9.1 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Folate_carrier PF01770.18 ETO02422.1 - 0.34 9.6 4.4 0.44 9.2 4.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier U-box PF04564.15 ETO02423.1 - 3.7e-14 52.7 0.1 8.2e-14 51.5 0.1 1.6 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO02423.1 - 0.013 15.7 0.0 0.019 15.1 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETO02423.1 - 0.038 13.8 0.1 0.092 12.6 0.0 1.7 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit DNApol_Exo PF18136.1 ETO02423.1 - 0.11 11.7 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain FERM_M PF00373.18 ETO02424.1 - 8.3e-14 52.0 0.5 8.3e-14 52.0 0.5 2.4 1 1 0 2 2 2 1 FERM central domain MyTH4 PF00784.17 ETO02424.1 - 2.5e-13 50.4 0.0 9.3e-13 48.6 0.0 2.0 1 0 0 1 1 1 1 MyTH4 domain RA PF00788.23 ETO02424.1 - 5.1e-05 23.8 0.2 0.00014 22.4 0.2 1.8 1 1 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_N PF09379.10 ETO02424.1 - 0.0029 17.5 0.0 0.0059 16.5 0.0 1.5 1 0 0 1 1 1 1 FERM N-terminal domain ABC_tran PF00005.27 ETO02425.1 - 4.8e-13 49.8 0.0 9.1e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ETO02425.1 - 1.2e-05 25.2 0.0 1.6e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ETO02425.1 - 0.00012 21.7 0.1 0.00028 20.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_membrane PF00664.23 ETO02425.1 - 0.0019 17.9 1.0 0.003 17.2 1.0 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region AAA_16 PF13191.6 ETO02425.1 - 0.0075 16.7 0.0 0.01 16.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ETO02425.1 - 0.0079 16.0 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_22 PF13401.6 ETO02425.1 - 0.01 16.1 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO02425.1 - 0.018 15.6 0.0 0.028 14.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain PRK PF00485.18 ETO02425.1 - 0.025 14.3 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family DUF87 PF01935.17 ETO02425.1 - 0.026 14.6 0.0 0.04 14.0 0.0 1.2 1 0 0 1 1 1 0 Helicase HerA, central domain AAA_18 PF13238.6 ETO02425.1 - 0.032 14.8 0.0 0.057 14.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ETO02425.1 - 0.034 13.8 0.0 0.054 13.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ETO02425.1 - 0.043 13.3 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_30 PF13604.6 ETO02425.1 - 0.044 13.5 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETO02425.1 - 0.045 13.5 0.0 0.085 12.6 0.0 1.4 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ETO02425.1 - 0.058 13.1 0.0 0.089 12.5 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein Rad17 PF03215.15 ETO02425.1 - 0.066 13.1 0.0 0.092 12.7 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_28 PF13521.6 ETO02425.1 - 0.14 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain SMC_N PF02463.19 ETO02425.1 - 0.16 11.4 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_33 PF13671.6 ETO02425.1 - 0.16 12.1 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain TniB PF05621.11 ETO02425.1 - 0.18 11.2 0.0 5.2 6.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial TniB protein Cytidylate_kin PF02224.18 ETO02425.1 - 0.19 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA_25 PF13481.6 ETO02425.1 - 0.2 11.2 0.0 0.29 10.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ETO02425.1 - 0.23 10.5 0.0 0.31 10.0 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF3987 PF13148.6 ETO02425.1 - 0.28 10.2 0.0 0.34 9.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) TPR_12 PF13424.6 ETO02426.1 - 4.2e-35 119.9 8.1 2.9e-19 69.1 0.7 5.8 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02426.1 - 4.6e-25 85.7 29.1 1.5e-08 34.2 0.4 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02426.1 - 7.3e-24 82.6 30.4 2e-07 30.5 0.7 7.1 7 1 0 7 7 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02426.1 - 1e-20 72.9 9.0 1.1e-08 34.6 0.1 6.6 7 2 0 7 7 7 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02426.1 - 9.6e-18 62.8 25.4 4.2e-06 26.5 0.6 6.7 6 1 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02426.1 - 2.3e-17 61.7 8.4 4.4e-05 23.2 0.1 5.7 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02426.1 - 9.6e-09 35.4 0.1 2.1 9.4 0.0 5.8 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02426.1 - 3.7e-08 33.2 6.2 4.1 8.0 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02426.1 - 7.1e-08 33.0 0.0 0.00076 20.1 0.1 3.7 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02426.1 - 8.3e-07 29.3 9.8 0.19 12.4 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02426.1 - 2.2e-06 27.2 16.6 0.29 10.8 0.1 7.6 7 2 1 8 8 7 2 TPR repeat TPR_MalT PF17874.1 ETO02426.1 - 0.00087 18.8 0.3 0.13 11.6 0.0 2.7 2 1 0 2 2 2 1 MalT-like TPR region MIT PF04212.18 ETO02426.1 - 0.0059 16.7 15.6 2.5 8.2 0.1 5.1 4 1 1 5 5 5 2 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO02426.1 - 0.0068 16.1 7.8 0.52 10.0 0.1 4.3 3 1 1 5 5 5 1 26S proteasome subunit RPN7 TPR_3 PF07720.12 ETO02426.1 - 0.015 15.3 18.0 0.1 12.6 1.7 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02426.1 - 0.018 14.8 0.2 0.018 14.8 0.2 4.7 3 2 2 5 5 5 0 Domain of unknown function (DUF5113) DUF357 PF04010.13 ETO02426.1 - 0.023 14.7 4.5 1.2 9.2 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF357) PPR PF01535.20 ETO02426.1 - 0.025 14.8 7.6 4.9 7.6 0.0 4.5 5 0 0 5 5 5 0 PPR repeat TPR_19 PF14559.6 ETO02426.1 - 0.029 14.9 1.5 0.29 11.7 0.2 2.9 3 1 0 3 3 2 0 Tetratricopeptide repeat HEPN_Toprim_N PF18871.1 ETO02426.1 - 0.037 14.0 1.3 4.2 7.2 0.1 2.6 1 1 1 2 2 2 0 HEPN/Toprim N-terminal domain 1 Sel1 PF08238.12 ETO02426.1 - 0.059 14.1 4.8 0.23 12.2 0.1 3.5 3 1 0 3 3 3 0 Sel1 repeat DHR10 PF18595.1 ETO02426.1 - 0.071 13.2 0.2 6.5 6.8 0.0 3.2 3 1 1 4 4 4 0 Designed helical repeat protein 10 domain Tup_N PF08581.10 ETO02426.1 - 1.8 8.9 4.5 32 4.9 0.6 2.9 2 0 0 2 2 2 0 Tup N-terminal DUF627 PF04781.12 ETO02426.1 - 2.4 8.2 5.6 4.4 7.4 0.0 3.3 4 1 1 5 5 3 0 Protein of unknown function (DUF627) PPR_2 PF13041.6 ETO02426.1 - 7.4 6.9 6.4 50 4.2 0.0 3.7 5 0 0 5 5 4 0 PPR repeat family MMR_HSR1 PF01926.23 ETO02428.1 - 4.5e-05 23.5 0.8 0.00031 20.8 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO02428.1 - 0.00024 21.0 3.7 0.00048 20.1 1.0 2.7 2 1 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 ETO02428.1 - 0.0038 17.8 0.2 0.0038 17.8 0.2 2.4 1 1 1 2 2 2 1 ABC transporter T2SSE PF00437.20 ETO02428.1 - 0.0059 15.7 0.1 0.012 14.7 0.1 1.5 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ETO02428.1 - 0.013 15.7 0.1 1.7 8.9 0.0 2.9 2 1 0 2 2 2 0 AAA domain PhoH PF02562.16 ETO02428.1 - 0.017 14.6 0.2 0.035 13.5 0.2 1.5 1 0 0 1 1 1 0 PhoH-like protein AAA_29 PF13555.6 ETO02428.1 - 0.022 14.5 0.1 0.05 13.4 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CX9C PF16860.5 ETO02428.1 - 0.023 14.7 3.9 0.063 13.3 3.9 1.7 1 0 0 1 1 1 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, AAA_7 PF12775.7 ETO02428.1 - 0.028 13.9 0.0 0.1 12.1 0.0 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region Spot_14 PF07084.12 ETO02428.1 - 0.034 14.3 0.7 0.11 12.6 0.7 1.9 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 AAA_19 PF13245.6 ETO02428.1 - 0.045 14.1 0.0 0.09 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO02428.1 - 0.059 13.6 0.1 0.19 11.9 0.1 2.0 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ETO02428.1 - 0.065 13.0 1.1 1.4 8.7 0.1 2.6 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation CoA_trans PF01144.23 ETO02428.1 - 0.11 11.8 0.0 0.22 10.9 0.0 1.4 1 0 0 1 1 1 0 Coenzyme A transferase PP2C PF00481.21 ETO02429.1 - 8.6e-55 186.1 0.2 9.9e-55 185.9 0.2 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ETO02429.1 - 5.2e-05 23.3 0.0 0.0002 21.3 0.0 1.7 2 0 0 2 2 2 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ETO02429.1 - 0.00046 19.9 0.0 0.00085 19.0 0.0 1.4 1 1 0 1 1 1 1 Protein phosphatase 2C MMR_HSR1 PF01926.23 ETO02431.1 - 4.1e-14 52.6 0.1 7.1e-14 51.9 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO02431.1 - 2.6e-08 33.5 0.1 4.9e-07 29.4 0.1 2.3 2 1 0 2 2 2 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ETO02431.1 - 2.9e-06 27.3 1.2 0.053 13.4 0.3 2.4 1 1 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ETO02431.1 - 0.0025 17.9 2.3 0.083 12.9 2.2 2.6 1 1 0 1 1 1 1 Dynamin family SRPRB PF09439.10 ETO02431.1 - 0.0056 16.1 0.1 0.01 15.3 0.1 1.4 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ETO02431.1 - 0.024 15.0 0.0 0.052 13.9 0.0 1.7 1 1 0 1 1 1 0 AAA ATPase domain AIG1 PF04548.16 ETO02431.1 - 0.084 12.2 0.2 0.17 11.2 0.2 1.5 1 0 0 1 1 1 0 AIG1 family CCDC32 PF14989.6 ETO02431.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing 32 DUF3074 PF11274.8 ETO02432.1 - 0.012 15.7 0.1 0.015 15.3 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3074) HEAT PF02985.22 ETO02433.1 - 7.8e-08 31.9 0.0 0.0074 16.5 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO02433.1 - 0.0001 22.6 0.0 0.00033 21.0 0.0 1.8 2 0 0 2 2 1 1 HEAT repeats DUF5105 PF17118.5 ETO02433.1 - 0.015 15.1 5.8 1.4 8.7 0.2 3.7 1 1 2 4 4 4 0 Domain of unknown function (DUF5105) Activator-TraM PF11657.8 ETO02433.1 - 0.043 13.7 0.3 0.12 12.2 0.1 1.8 2 0 0 2 2 2 0 Transcriptional activator TraM RPAP3_C PF13877.6 ETO02433.1 - 0.045 14.3 1.0 0.57 10.8 0.3 2.9 2 1 0 2 2 2 0 Potential Monad-binding region of RPAP3 CHASE5 PF17149.4 ETO02433.1 - 0.066 13.1 0.4 1.8 8.6 0.1 3.0 2 1 1 3 3 3 0 Periplasmic sensor domain found in signal transduction proteins NLE PF08154.12 ETO02433.1 - 0.069 13.7 6.0 1.4 9.5 0.3 3.6 2 1 1 3 3 3 0 NLE (NUC135) domain DUF3349 PF11829.8 ETO02433.1 - 0.078 13.8 0.8 4.7 8.1 0.1 3.1 2 2 1 3 3 3 0 Protein of unknown function (DUF3349) HEAT_EZ PF13513.6 ETO02433.1 - 0.12 12.9 0.0 0.27 11.8 0.0 1.6 1 0 0 1 1 1 0 HEAT-like repeat XkdW PF09636.10 ETO02433.1 - 0.43 10.7 3.8 7.6 6.7 0.2 3.0 2 1 1 3 3 3 0 XkdW protein L27_N PF09060.10 ETO02433.1 - 8.5 6.5 6.6 16 5.6 0.6 3.8 5 0 0 5 5 5 0 L27_N DUF4366 PF14283.6 ETO02434.1 - 0.18 11.8 2.6 0.25 11.4 0.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4366) TLD PF07534.16 ETO02435.1 - 1.7e-12 47.7 0.5 8.1e-12 45.5 0.1 2.0 2 0 0 2 2 2 1 TLD DUF3246 PF11596.8 ETO02437.1 - 0.007 15.8 1.3 0.0082 15.6 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) DUF4611 PF15387.6 ETO02437.1 - 0.011 16.0 0.9 0.016 15.4 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ETO02437.1 - 0.087 12.5 0.2 0.12 12.1 0.2 1.2 1 0 0 1 1 1 0 FAM176 family DUF3245 PF11595.8 ETO02437.1 - 0.19 12.2 2.5 0.23 11.9 2.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) DUF3867 PF12983.7 ETO02438.1 - 0.052 13.6 0.5 0.18 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3867) EFhand_Ca_insen PF08726.10 ETO02439.1 - 0.021 14.9 0.8 0.69 10.0 0.1 2.2 1 1 1 2 2 2 0 Ca2+ insensitive EF hand Y_phosphatase2 PF03162.13 ETO02439.1 - 0.025 14.1 0.7 0.032 13.8 0.4 1.4 1 1 0 1 1 1 0 Tyrosine phosphatase family SOAR PF16533.5 ETO02439.1 - 0.14 12.1 4.8 0.45 10.5 4.8 1.7 1 1 0 1 1 1 0 STIM1 Orai1-activating region LapA_dom PF06305.11 ETO02439.1 - 1 9.3 4.0 0.55 10.1 1.3 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Pkinase PF00069.25 ETO02440.1 - 2.1e-05 24.1 0.0 2.4e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO02440.1 - 0.0013 18.1 0.1 0.0016 17.7 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase CysG_dimeriser PF10414.9 ETO02441.1 - 0.045 13.5 0.0 0.92 9.3 0.0 2.4 2 0 0 2 2 2 0 Sirohaem synthase dimerisation region GCR1_C PF12550.8 ETO02441.1 - 0.32 11.4 4.9 0.1 13.0 1.0 2.2 2 1 0 3 3 3 0 Transcriptional activator of glycolytic enzymes HSCB_C PF07743.13 ETO02442.1 - 1.1 9.7 7.8 1.5 9.3 1.2 2.5 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain DUF2115 PF09888.9 ETO02442.1 - 9.2 6.8 7.8 6 7.4 4.2 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) Cation_ATPase_N PF00690.26 ETO02444.1 - 7.4e-16 57.6 0.0 1.3e-15 56.8 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus ThrE PF06738.12 ETO02444.1 - 0.049 13.0 0.4 0.25 10.7 0.6 1.8 2 0 0 2 2 2 0 Putative threonine/serine exporter GCR1_C PF12550.8 ETO02444.1 - 0.19 12.1 2.7 0.6 10.5 0.1 2.2 2 0 0 2 2 2 0 Transcriptional activator of glycolytic enzymes DUF4549 PF15082.6 ETO02444.1 - 0.84 9.4 4.9 0.46 10.3 1.8 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4549) DEAD PF00270.29 ETO02445.1 - 2.7e-29 102.2 0.1 4.1e-29 101.6 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Presenilin PF01080.17 ETO02445.1 - 0.025 13.4 4.9 0.025 13.4 4.9 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 ETO02445.1 - 0.49 10.4 7.3 0.62 10.0 7.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Zip PF02535.22 ETO02445.1 - 1.8 7.7 5.2 2.2 7.4 5.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter F-protein PF00469.20 ETO02445.1 - 3.6 7.1 11.6 5 6.7 11.6 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DUF4775 PF16001.5 ETO02445.1 - 3.7 6.9 24.4 5 6.4 24.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Band_3_cyto PF07565.13 ETO02445.1 - 4.9 6.9 8.0 6.6 6.4 8.0 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain PTPRCAP PF15713.5 ETO02445.1 - 8.8 6.6 16.3 14 5.9 16.3 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TRAP_alpha PF03896.16 ETO02446.1 - 0.0058 15.9 0.3 0.0058 15.9 0.3 1.8 1 1 1 2 2 2 1 Translocon-associated protein (TRAP), alpha subunit SARAF PF06682.12 ETO02446.1 - 0.14 11.8 0.1 0.17 11.5 0.1 1.3 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis RGS PF00615.19 ETO02447.1 - 2.1e-05 24.8 4.6 2.7e-05 24.4 1.3 2.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain Na_H_Exchanger PF00999.21 ETO02447.1 - 0.001 17.9 9.8 0.0015 17.4 9.8 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family MadM PF03818.13 ETO02447.1 - 0.53 10.2 5.2 1.5 8.8 5.2 1.7 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit RseC_MucC PF04246.12 ETO02447.1 - 3.6 7.6 7.4 0.17 11.8 0.4 2.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Helicase_C PF00271.31 ETO02448.1 - 1.2e-26 93.3 0.0 5.3e-26 91.1 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ETO02448.1 - 1e-05 25.6 0.2 2.2e-05 24.6 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) DEAD PF00270.29 ETO02448.1 - 0.042 13.6 0.0 0.13 12.0 0.0 1.8 1 0 0 1 1 1 0 DEAD/DEAH box helicase Ac110_PIF PF07280.11 ETO02452.1 - 0.47 10.3 3.8 51 3.8 0.2 3.1 3 0 0 3 3 3 0 Per os infectivity factor AC110 Tubulin PF00091.25 ETO02453.1 - 7.1e-24 85.1 0.0 8.8e-24 84.8 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO02453.1 - 0.082 13.1 0.1 0.15 12.2 0.1 1.5 1 0 0 1 1 1 0 Tubulin C-terminal domain ABC_tran PF00005.27 ETO02454.1 - 7e-06 26.6 0.1 0.00019 22.0 0.0 2.3 2 1 0 2 2 2 1 ABC transporter AAA_5 PF07728.14 ETO02454.1 - 0.00021 21.3 0.0 0.00045 20.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO02454.1 - 0.00023 21.6 0.0 0.00057 20.3 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ETO02454.1 - 0.0017 18.3 0.1 0.0042 17.0 0.0 1.6 1 1 0 1 1 1 1 RsgA GTPase AAA_7 PF12775.7 ETO02454.1 - 0.003 17.1 0.1 0.0067 16.0 0.1 1.7 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_23 PF13476.6 ETO02454.1 - 0.012 16.1 0.6 0.012 16.1 0.6 2.4 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO02454.1 - 0.013 15.7 0.0 0.064 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ETO02454.1 - 0.014 15.3 5.2 0.044 13.7 0.0 3.4 3 2 1 4 4 4 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO02454.1 - 0.015 15.7 0.0 0.03 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ETO02454.1 - 0.083 12.8 0.1 0.47 10.4 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ATP-synt_ab PF00006.25 ETO02454.1 - 0.099 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Cas_APE2256 PF09651.10 ETO02454.1 - 0.12 12.3 0.0 0.37 10.7 0.0 1.8 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_APE2256) TrmK PF04816.12 ETO02454.1 - 0.16 11.5 4.4 5.4 6.5 0.7 2.9 2 1 1 3 3 3 0 tRNA (adenine(22)-N(1))-methyltransferase TsaE PF02367.17 ETO02454.1 - 0.17 11.9 0.4 0.45 10.5 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATG27 PF09451.10 ETO02458.1 - 2e-06 27.9 1.5 2.5e-06 27.6 1.5 1.0 1 0 0 1 1 1 1 Autophagy-related protein 27 GSH_synthase PF03199.15 ETO02458.1 - 0.034 14.6 3.5 0.077 13.4 0.1 2.1 2 0 0 2 2 2 0 Eukaryotic glutathione synthase DUF1837 PF08878.11 ETO02458.1 - 0.11 12.3 6.4 0.13 12.1 5.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1837) Orf78 PF06024.12 ETO02458.1 - 1.4 9.3 7.7 0.31 11.4 0.6 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Calcyon PF06387.11 ETO02458.1 - 6.7 6.7 11.0 0.66 9.9 3.7 2.0 1 1 1 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) Peptidase_M56 PF05569.11 ETO02459.1 - 0.0048 16.1 2.3 0.85 8.7 0.8 2.4 2 0 0 2 2 2 2 BlaR1 peptidase M56 7tm_1 PF00001.21 ETO02459.1 - 0.019 14.3 0.2 0.88 8.8 0.0 2.4 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) MARVEL PF01284.23 ETO02459.1 - 0.082 12.9 1.9 0.27 11.3 0.2 2.0 2 0 0 2 2 2 0 Membrane-associating domain DHHC PF01529.20 ETO02459.1 - 0.31 11.1 6.5 6.1 7.0 0.1 2.6 2 1 0 2 2 2 0 DHHC palmitoyltransferase PspB PF06667.12 ETO02459.1 - 0.95 9.6 5.3 3.9 7.6 0.4 3.6 3 1 0 3 3 3 0 Phage shock protein B Activator-TraM PF11657.8 ETO02460.1 - 0.0031 17.4 0.1 0.0041 16.9 0.1 1.2 1 0 0 1 1 1 1 Transcriptional activator TraM FlaF PF07309.11 ETO02460.1 - 0.072 13.1 0.0 0.16 12.0 0.0 1.5 2 0 0 2 2 2 0 Flagellar protein FlaF Myosin_head PF00063.21 ETO02461.1 - 8.6e-90 301.9 0.3 9.5e-90 301.7 0.3 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) Thioredoxin PF00085.20 ETO02463.1 - 2.2e-09 37.2 0.1 4.6e-09 36.2 0.1 1.6 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_7 PF13899.6 ETO02463.1 - 0.015 15.5 0.0 0.033 14.3 0.0 1.7 1 1 0 1 1 1 0 Thioredoxin-like Glycos_transf_1 PF00534.20 ETO02463.1 - 0.016 14.8 0.1 0.023 14.3 0.1 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_hydro_59M PF17387.2 ETO02463.1 - 0.021 15.0 0.0 0.033 14.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 59 central domain zf-TRAF PF02176.18 ETO02466.1 - 6.8e-05 23.5 6.1 6.8e-05 23.5 6.1 2.7 1 1 2 3 3 3 1 TRAF-type zinc finger Cyto_heme_lyase PF01265.17 ETO02466.1 - 0.38 10.3 3.0 0.48 10.0 3.0 1.1 1 0 0 1 1 1 0 Cytochrome c/c1 heme lyase PARM PF17061.5 ETO02467.1 - 0.047 13.8 6.2 0.055 13.6 6.2 1.0 1 0 0 1 1 1 0 PARM HrpJ PF07201.11 ETO02469.1 - 0.019 15.3 6.1 0.022 15.1 6.1 1.1 1 0 0 1 1 1 0 HrpJ-like domain DUF4407 PF14362.6 ETO02469.1 - 0.56 9.5 6.7 0.6 9.4 6.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2828 PF11443.8 ETO02469.1 - 2 6.4 8.9 2.3 6.2 8.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 ETO02469.1 - 2 8.1 7.6 2.1 8.0 7.6 1.0 1 0 0 1 1 1 0 Connexin PhetRS_B1 PF18262.1 ETO02474.1 - 0.087 13.1 0.2 0.83 9.9 0.1 2.0 2 0 0 2 2 2 0 Phe-tRNA synthetase beta subunit B1 domain WD40 PF00400.32 ETO02475.1 - 8.7e-38 127.7 7.7 1.8e-11 44.3 0.1 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02475.1 - 5.1e-17 62.0 0.4 0.00081 19.6 0.0 4.6 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO02475.1 - 5.1e-07 29.5 0.6 0.38 10.8 0.0 4.4 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO02475.1 - 3.1e-05 23.1 0.1 0.28 10.1 0.0 3.3 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO02475.1 - 0.00013 21.4 0.1 0.019 14.3 0.0 2.4 1 1 2 3 3 3 3 WD40-like domain PQQ_2 PF13360.6 ETO02475.1 - 0.0009 18.9 0.2 0.006 16.2 0.1 2.1 1 1 0 1 1 1 1 PQQ-like domain Frtz PF11768.8 ETO02475.1 - 0.003 16.0 0.0 0.59 8.4 0.0 2.8 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz PQQ PF01011.21 ETO02475.1 - 0.018 15.0 0.0 16 5.6 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat RE_XamI PF09572.10 ETO02475.1 - 0.047 13.4 0.0 18 4.9 0.0 2.8 1 1 2 3 3 3 0 XamI restriction endonuclease DUF4072 PF13284.6 ETO02475.1 - 0.069 13.6 0.0 26 5.3 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4072) DUF1652 PF07865.11 ETO02475.1 - 0.072 12.9 0.0 18 5.2 0.0 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1652) Proteasome_A_N PF10584.9 ETO02475.1 - 0.11 12.3 5.9 5.4 6.8 0.2 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO02475.1 - 0.15 12.2 2.1 15 5.7 0.1 3.0 1 1 3 4 4 4 0 Family of unknown function (DUF5570) FAM176 PF14851.6 ETO02476.1 - 0.1 12.3 3.8 0.25 11.0 3.8 1.7 1 1 0 1 1 1 0 FAM176 family DUF3464 PF11947.8 ETO02476.1 - 0.26 11.1 1.7 1.6 8.5 2.9 1.7 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 DUF2098 PF09871.9 ETO02476.1 - 1.2 9.5 6.8 2.4 8.6 6.3 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) WD40 PF00400.32 ETO02478.1 - 0.00078 20.2 0.8 0.01 16.7 0.2 2.3 2 1 0 2 2 2 1 WD domain, G-beta repeat HTH_19 PF12844.7 ETO02478.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Helix-turn-helix domain Pkinase PF00069.25 ETO02480.1 - 0.0002 20.8 0.3 0.00032 20.1 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain ABC2_membrane_3 PF12698.7 ETO02484.1 - 0.0017 17.6 1.5 0.0017 17.5 1.5 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF3270 PF11674.8 ETO02484.1 - 0.22 11.7 3.1 0.38 11.0 3.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3270) Kelch_6 PF13964.6 ETO02486.1 - 0.00027 21.1 0.9 0.0028 17.9 0.1 2.3 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO02486.1 - 0.00063 19.7 0.4 0.054 13.5 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO02486.1 - 0.043 14.1 0.0 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 Galactose oxidase, central domain WD40 PF00400.32 ETO02487.1 - 7.2e-21 74.1 16.4 2.8e-07 31.1 0.3 6.2 5 3 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02487.1 - 0.00016 21.9 0.3 1.5 9.2 0.0 4.1 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02487.1 - 0.00081 18.2 0.6 0.72 8.4 0.0 3.7 3 1 1 4 4 4 1 Nucleoporin Nup120/160 DUF4550 PF15084.6 ETO02487.1 - 0.00087 19.7 0.3 0.078 13.4 0.1 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4550) Nucleoporin_N PF08801.11 ETO02487.1 - 0.026 13.3 0.9 1.4 7.6 0.7 2.6 2 1 0 2 2 2 0 Nup133 N terminal like GDA1_CD39 PF01150.17 ETO02488.1 - 2.3e-74 250.6 0.0 3.6e-74 249.9 0.0 1.1 1 0 0 1 1 1 1 GDA1/CD39 (nucleoside phosphatase) family NIF3 PF01784.18 ETO02489.1 - 0.1 12.2 0.2 0.1 12.2 0.2 1.1 1 0 0 1 1 1 0 NIF3 (NGG1p interacting factor 3) UCH PF00443.29 ETO02491.1 - 4.9e-08 32.8 0.6 7e-08 32.3 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UPF0172 PF03665.13 ETO02492.1 - 0.012 15.6 0.0 0.018 15.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) Kelch_6 PF13964.6 ETO02492.1 - 0.021 15.1 0.4 0.37 11.2 0.1 3.1 3 2 0 3 3 3 0 Kelch motif Peptidase_C14 PF00656.22 ETO02493.1 - 3e-07 30.6 0.4 1.9e-06 28.0 0.4 2.0 1 1 0 1 1 1 1 Caspase domain MRP-S26 PF14943.6 ETO02494.1 - 0.63 9.9 12.8 1 9.3 12.8 1.2 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 TPM_phosphatase PF04536.14 ETO02495.1 - 1.4e-13 51.1 0.8 2e-13 50.6 0.0 1.6 2 0 0 2 2 1 1 TPM domain zf-RING_2 PF13639.6 ETO02495.1 - 1.9e-10 40.9 8.6 3.9e-10 39.9 8.6 1.5 1 0 0 1 1 1 1 Ring finger domain MOLO1 PF17175.4 ETO02495.1 - 5.9e-09 36.1 2.3 1.8e-08 34.6 0.9 2.3 2 1 0 2 2 2 1 Modulator of levamisole receptor-1 zf-C3HC4 PF00097.25 ETO02495.1 - 7.2e-09 35.4 7.2 1.6e-08 34.3 7.2 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO02495.1 - 1.4e-07 31.3 7.4 2.7e-07 30.3 7.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO02495.1 - 4.3e-07 29.9 7.3 4.3e-07 29.9 7.3 2.7 2 1 0 2 2 2 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ETO02495.1 - 7.8e-06 25.7 10.9 7.3e-05 22.6 10.6 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETO02495.1 - 1.3e-05 24.9 7.8 3.5e-05 23.5 7.8 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO02495.1 - 6.4e-05 22.8 7.5 0.00017 21.5 7.5 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_4 PF14570.6 ETO02495.1 - 0.00078 19.2 8.9 0.0019 17.9 8.9 1.7 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ETO02495.1 - 0.0016 18.4 3.6 0.0036 17.3 3.6 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ETO02495.1 - 0.0049 16.6 3.4 0.0049 16.6 3.4 1.9 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 ETO02495.1 - 0.0097 16.0 12.0 0.11 12.6 12.1 2.4 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 ETO02495.1 - 0.0098 15.3 0.5 0.0098 15.3 0.5 1.6 2 0 0 2 2 2 1 Rtf2 RING-finger zf-UDP PF14569.6 ETO02495.1 - 0.015 15.4 3.1 0.033 14.3 3.1 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-rbx1 PF12678.7 ETO02495.1 - 0.028 14.7 10.4 0.17 12.2 10.4 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain OrfB_Zn_ribbon PF07282.11 ETO02495.1 - 0.57 10.1 5.2 1.1 9.2 1.5 2.6 1 1 1 2 2 2 0 Putative transposase DNA-binding domain zf-Nse PF11789.8 ETO02495.1 - 0.86 9.5 3.7 3.7 7.4 3.7 2.1 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TPM_phosphatase PF04536.14 ETO02496.1 - 2.9e-13 50.1 0.0 4.7e-13 49.4 0.0 1.3 1 0 0 1 1 1 1 TPM domain zf-RING_2 PF13639.6 ETO02496.1 - 2e-10 40.8 8.8 2e-10 40.8 8.8 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO02496.1 - 1.7e-08 34.2 7.4 4.3e-08 32.9 7.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO02496.1 - 1.2e-07 31.6 6.1 9.3e-07 28.8 6.3 2.4 1 1 1 2 2 2 1 RING-type zinc-finger MOLO1 PF17175.4 ETO02496.1 - 2e-06 27.9 0.0 4e-06 27.0 0.0 1.4 1 0 0 1 1 1 1 Modulator of levamisole receptor-1 zf-C3HC4_2 PF13923.6 ETO02496.1 - 2.2e-05 24.2 8.8 7.6e-05 22.5 8.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO02496.1 - 8.4e-05 22.4 9.3 0.00014 21.7 8.2 2.1 1 1 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO02496.1 - 0.0005 19.9 12.8 0.0056 16.5 11.7 2.5 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETO02496.1 - 0.0013 18.7 3.9 0.0029 17.6 3.9 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 ETO02496.1 - 0.011 15.5 9.1 0.011 15.5 9.1 2.2 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 ETO02496.1 - 0.016 15.5 11.9 0.093 13.0 11.9 2.3 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-UDP PF14569.6 ETO02496.1 - 0.017 15.2 3.0 0.035 14.2 3.0 1.5 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-C3HC4_4 PF15227.6 ETO02496.1 - 0.036 14.2 10.3 0.036 14.2 10.3 2.8 2 1 0 2 2 1 0 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 ETO02496.1 - 0.038 13.3 1.5 0.057 12.8 1.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger DUF1244 PF06844.11 ETO02496.1 - 0.3 11.3 2.6 0.66 10.2 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1244) Saf_2TM PF18303.1 ETO02496.1 - 0.31 10.6 2.5 1.8 8.1 0.0 2.4 1 1 0 2 2 2 0 SAVED-fused 2TM effector domain zf-Nse PF11789.8 ETO02496.1 - 0.5 10.2 4.2 1.5 8.7 4.1 1.8 1 1 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit TRIQK PF15168.6 ETO02496.1 - 0.61 10.0 2.1 1.7 8.6 2.1 1.7 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family zf-RING_10 PF16685.5 ETO02496.1 - 1.6 8.9 8.3 0.24 11.6 3.9 2.0 2 0 0 2 2 1 0 zinc RING finger of MSL2 zf-RING_11 PF17123.5 ETO02496.1 - 1.9 8.3 9.4 0.089 12.6 3.4 2.1 2 0 0 2 2 2 0 RING-like zinc finger OrfB_Zn_ribbon PF07282.11 ETO02496.1 - 2.1 8.3 6.7 1.8 8.6 2.7 2.3 1 1 1 2 2 2 0 Putative transposase DNA-binding domain Cation_ATPase_C PF00689.21 ETO02497.1 - 0.0085 15.8 2.7 0.0099 15.6 2.7 1.1 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus DUF2576 PF10845.8 ETO02497.1 - 0.55 9.9 0.1 0.55 9.9 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2576) DUF4710 PF15828.5 ETO02497.1 - 0.88 9.7 6.6 1.4 9.1 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) TPR_12 PF13424.6 ETO02498.1 - 6.2e-08 32.8 0.0 1.4e-05 25.3 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02498.1 - 1.4e-07 31.1 0.3 7.8e-06 25.5 0.3 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02498.1 - 3.9e-06 26.6 1.0 0.00051 20.0 0.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02498.1 - 6.1e-05 22.9 0.7 0.0016 18.5 0.2 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02498.1 - 6.9e-05 22.6 0.0 0.00049 19.9 0.1 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02498.1 - 0.00036 20.3 0.1 0.0064 16.4 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat HEPN PF05168.14 ETO02498.1 - 0.081 13.1 0.1 0.13 12.4 0.1 1.3 1 0 0 1 1 1 0 HEPN domain TPR_11 PF13414.6 ETO02498.1 - 0.17 11.6 0.8 0.49 10.1 0.2 2.1 2 0 0 2 2 2 0 TPR repeat RNB PF00773.19 ETO02499.1 - 8e-33 114.1 0.1 9e-33 114.0 0.1 1.0 1 0 0 1 1 1 1 RNB domain Ribosomal_S8 PF00410.19 ETO02500.1 - 0.1 12.6 0.9 0.17 11.8 0.9 1.3 1 0 0 1 1 1 0 Ribosomal protein S8 Peptidase_C14 PF00656.22 ETO02501.1 - 2.3e-13 50.7 0.6 3.5e-13 50.1 0.6 1.3 1 0 0 1 1 1 1 Caspase domain HEAT PF02985.22 ETO02502.1 - 1.1e-07 31.4 0.1 5 7.7 0.0 6.4 7 0 0 7 7 5 1 HEAT repeat TIP120 PF08623.10 ETO02502.1 - 3.4e-05 23.7 17.9 0.19 11.5 0.1 6.5 3 2 2 6 6 6 3 TATA-binding protein interacting (TIP20) Ank_2 PF12796.7 ETO02502.1 - 9.7e-05 22.9 5.1 0.00033 21.2 0.0 4.3 4 1 0 5 5 4 1 Ankyrin repeats (3 copies) HEAT_EZ PF13513.6 ETO02502.1 - 0.00028 21.3 0.5 12 6.5 0.0 5.8 7 0 0 7 7 5 1 HEAT-like repeat HEAT_2 PF13646.6 ETO02502.1 - 0.0011 19.3 0.0 5.6 7.4 0.0 4.4 2 1 1 4 4 4 1 HEAT repeats Ank_4 PF13637.6 ETO02502.1 - 0.0026 18.3 0.3 0.012 16.2 0.3 2.2 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO02502.1 - 0.005 17.2 0.1 0.15 12.7 0.0 3.3 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ETO02502.1 - 0.0059 17.0 0.0 0.026 15.0 0.0 2.2 1 0 0 1 1 1 1 Ankyrin repeat Vac14_Fab1_bd PF12755.7 ETO02502.1 - 0.0076 16.8 11.7 1.3 9.7 0.2 5.7 5 2 0 5 5 4 1 Vacuolar 14 Fab1-binding region DUF5071 PF16804.5 ETO02502.1 - 0.048 13.9 23.6 0.1 12.9 1.2 6.3 5 2 3 8 8 8 0 Domain of unknown function (DUF5071) Utp12 PF04003.12 ETO02502.1 - 0.25 11.7 4.2 3.2 8.1 0.6 3.6 3 0 0 3 3 3 0 Dip2/Utp12 Family MnmE_helical PF12631.7 ETO02502.1 - 3.8 7.6 15.7 0.17 12.1 6.3 3.3 3 1 1 4 4 4 0 MnmE helical domain GlutR_dimer PF00745.20 ETO02502.1 - 4.4 7.8 13.5 14 6.3 0.3 6.0 5 1 1 6 6 6 0 Glutamyl-tRNAGlu reductase, dimerisation domain WIYLD PF10440.9 ETO02502.1 - 6.7 6.6 9.8 3.6 7.4 0.1 4.9 6 0 0 6 6 6 0 Ubiquitin-binding WIYLD domain DUF2400 PF09674.10 ETO02503.1 - 0.05 13.6 0.2 0.054 13.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) ABC_tran PF00005.27 ETO02505.1 - 0.0018 18.8 2.5 0.019 15.5 0.2 2.1 1 1 1 2 2 2 1 ABC transporter DUF2813 PF11398.8 ETO02505.1 - 0.015 14.6 0.4 0.02 14.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2813) AAA_7 PF12775.7 ETO02505.1 - 0.035 13.6 1.6 0.055 13.0 0.1 2.1 2 1 1 3 3 3 0 P-loop containing dynein motor region AAA_16 PF13191.6 ETO02505.1 - 0.059 13.8 0.1 0.13 12.7 0.1 1.6 1 1 1 2 2 2 0 AAA ATPase domain MCM PF00493.23 ETO02505.1 - 0.06 12.4 0.2 0.22 10.6 0.1 1.8 1 1 1 2 2 2 0 MCM P-loop domain Sigma54_activat PF00158.26 ETO02505.1 - 0.076 12.7 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 ETO02505.1 - 0.095 13.0 2.4 0.6 10.4 0.5 2.2 2 1 0 2 2 2 0 AAA domain CH PF00307.31 ETO02507.1 - 2.9e-07 30.6 0.2 4.4e-07 30.1 0.1 1.4 2 0 0 2 2 2 1 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO02507.1 - 0.12 12.2 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 CAMSAP CH domain GSH-S_ATP PF02955.16 ETO02508.1 - 5.9e-56 188.6 0.5 5.9e-56 188.6 0.5 2.2 3 0 0 3 3 3 1 Prokaryotic glutathione synthetase, ATP-grasp domain N6_Mtase PF02384.16 ETO02508.1 - 3.6e-42 144.7 1.2 4.7e-41 141.1 1.2 2.5 1 1 0 1 1 1 1 N-6 DNA Methylase GSH-S_N PF02951.14 ETO02508.1 - 1e-26 93.4 0.0 4.6e-26 91.3 0.0 2.1 2 0 0 2 2 2 1 Prokaryotic glutathione synthetase, N-terminal domain RimK PF08443.11 ETO02508.1 - 1.2e-14 54.3 0.3 7.1e-14 51.8 0.4 2.2 2 0 0 2 2 2 1 RimK-like ATP-grasp domain UPF0020 PF01170.18 ETO02508.1 - 0.00014 21.6 0.0 0.00037 20.3 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 ETO02508.1 - 0.0006 19.6 0.0 0.0013 18.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETO02508.1 - 0.00087 18.9 0.0 0.0069 16.0 0.0 2.4 1 1 0 1 1 1 1 Methyltransferase small domain Eco57I PF07669.11 ETO02508.1 - 0.0035 17.8 0.1 0.012 16.1 0.1 2.0 1 0 0 1 1 1 1 Eco57I restriction-modification methylase ATPgrasp_YheCD PF14398.6 ETO02508.1 - 0.048 12.9 1.8 0.15 11.3 0.1 2.6 3 0 0 3 3 3 0 YheC/D like ATP-grasp Propeptide_C1 PF08127.13 ETO02508.1 - 0.052 13.4 0.2 0.21 11.5 0.2 2.1 1 0 0 1 1 1 0 Peptidase family C1 propeptide Asn_synthase PF00733.21 ETO02509.1 - 0.0041 16.8 0.0 0.0044 16.7 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 ETO02509.1 - 0.0067 15.6 0.0 0.0076 15.4 0.0 1.1 1 0 0 1 1 1 1 NAD synthase TPR_12 PF13424.6 ETO02511.1 - 3.2e-22 78.6 2.6 1.3e-14 54.2 0.1 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02511.1 - 1.4e-15 56.6 2.5 0.00028 20.6 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02511.1 - 1.6e-15 55.9 4.6 0.001 19.0 0.0 5.1 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02511.1 - 1e-12 47.3 32.3 5.3e-05 22.9 0.7 6.1 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02511.1 - 1.2e-09 37.5 22.8 3.6e-05 23.5 0.6 5.7 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02511.1 - 5.1e-09 35.6 27.8 0.0085 16.2 0.5 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02511.1 - 0.00014 22.4 0.0 0.74 10.8 0.0 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02511.1 - 0.0045 17.6 0.0 1.3 9.8 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO02511.1 - 0.0068 15.8 2.2 3.6 7.1 0.0 3.9 4 0 0 4 4 4 1 SHNi-TPR TPR_6 PF13174.6 ETO02511.1 - 0.0072 16.9 1.8 3.8 8.4 0.3 3.4 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO02511.1 - 0.01 15.8 9.6 0.16 12.0 4.3 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO02511.1 - 0.025 14.1 5.6 20 4.9 0.0 4.7 4 0 0 4 4 4 0 Helix-turn-helix bacterial domain TPR_17 PF13431.6 ETO02511.1 - 0.044 14.2 14.6 3.2 8.3 0.1 5.1 5 1 0 5 5 4 0 Tetratricopeptide repeat DUF5362 PF17319.2 ETO02511.1 - 0.13 12.1 0.1 0.42 10.5 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5362) ANAPC3 PF12895.7 ETO02511.1 - 0.16 12.2 11.8 2.6 8.3 2.2 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO02511.1 - 0.17 11.7 22.1 0.19 11.5 0.1 4.5 3 1 2 5 5 5 0 Domain of unknown function (DUF5113) PPR PF01535.20 ETO02511.1 - 0.18 12.1 0.7 9.7 6.7 0.1 3.1 2 0 0 2 2 2 0 PPR repeat TEX12 PF15219.6 ETO02511.1 - 1.7 9.0 6.6 1.3 9.3 3.1 2.4 1 1 1 2 2 2 0 Testis-expressed 12 TPR_11 PF13414.6 ETO02511.1 - 2.7 7.7 27.7 0.21 11.3 0.5 5.2 4 1 0 4 4 4 0 TPR repeat TLD PF07534.16 ETO02516.1 - 1.5e-17 64.1 6.7 8.7e-16 58.4 2.4 3.0 2 0 0 2 2 2 2 TLD G-gamma PF00631.22 ETO02516.1 - 0.024 14.7 1.6 0.068 13.2 0.9 2.2 2 0 0 2 2 2 0 GGL domain Pterin_bind PF00809.22 ETO02516.1 - 0.065 12.9 1.8 0.14 11.8 1.3 1.8 1 1 0 1 1 1 0 Pterin binding enzyme ALS_ss_C PF10369.9 ETO02516.1 - 0.96 9.7 3.3 5.6 7.3 0.1 2.9 2 1 1 3 3 3 0 Small subunit of acetolactate synthase Vac_Fusion PF02346.16 ETO02516.1 - 2.3 7.9 5.8 2 8.1 0.9 2.6 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 Terminase_4 PF05119.12 ETO02516.1 - 2.5 8.6 10.4 0.23 11.9 0.5 3.1 3 1 0 3 3 3 0 Phage terminase, small subunit PIN_2 PF10130.9 ETO02516.1 - 4.6 7.5 8.8 0.96 9.7 4.3 2.2 2 1 1 3 3 3 0 PIN domain KIP1 PF07765.12 ETO02516.1 - 7.4 6.8 12.2 10 6.3 4.5 2.9 2 1 0 2 2 2 0 KIP1-like protein Peptidase_M24 PF00557.24 ETO02519.1 - 3.6e-40 137.9 0.1 4.3e-40 137.7 0.1 1.0 1 0 0 1 1 1 1 Metallopeptidase family M24 HJURP_mid PF12346.8 ETO02520.1 - 0.0046 17.4 1.3 0.0095 16.4 1.3 1.5 1 0 0 1 1 1 1 Holliday junction recognition protein-associated repeat Connexin PF00029.19 ETO02520.1 - 0.0093 15.8 1.5 0.019 14.8 1.5 1.4 1 0 0 1 1 1 1 Connexin GAGA_bind PF06217.12 ETO02520.1 - 0.017 15.4 5.8 0.023 15.0 5.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family CLN3 PF02487.17 ETO02520.1 - 0.047 12.7 0.6 0.075 12.1 0.6 1.3 1 0 0 1 1 1 0 CLN3 protein Plasmid_parti PF01672.16 ETO02520.1 - 0.11 13.1 0.6 0.11 13.1 0.6 2.7 3 0 0 3 3 3 0 Putative plasmid partition protein Presenilin PF01080.17 ETO02520.1 - 0.11 11.2 1.9 0.13 11.1 1.9 1.2 1 0 0 1 1 1 0 Presenilin FHIPEP PF00771.20 ETO02520.1 - 0.17 10.3 1.8 0.91 7.9 0.2 2.0 2 0 0 2 2 2 0 FHIPEP family DUF4834 PF16118.5 ETO02520.1 - 0.56 11.2 3.8 0.16 12.9 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF733 PF05306.11 ETO02520.1 - 1.4 9.2 7.8 0.19 12.0 3.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF733) Trypan_PARP PF05887.11 ETO02520.1 - 2.6 8.0 10.7 4.3 7.3 10.7 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SKA1 PF07160.12 ETO02520.1 - 4.9 6.9 13.5 2.2 8.1 7.5 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Menin PF05053.13 ETO02520.1 - 5.2 5.3 7.6 1.3 7.3 1.5 2.0 2 0 0 2 2 2 0 Menin Peptidase_S49 PF01343.18 ETO02521.1 - 2.9e-05 24.1 0.0 3.1e-05 23.9 0.0 1.0 1 0 0 1 1 1 1 Peptidase family S49 LnmK_N_HDF PF18238.1 ETO02522.1 - 0.0065 16.3 0.0 0.0068 16.2 0.0 1.1 1 0 0 1 1 1 1 LnmK N-terminal Hot Dog Fold domain CmlA_N PF18456.1 ETO02523.1 - 0.024 13.9 0.9 0.032 13.5 0.9 1.2 1 0 0 1 1 1 0 Diiron non-heme beta-hydroxylase N-terminal domain ETRAMP PF09716.10 ETO02524.1 - 0.0024 17.9 0.0 0.0098 15.9 0.0 2.0 1 1 1 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) HlyC PF02794.16 ETO02525.1 - 0.029 14.2 0.7 0.092 12.6 0.2 2.1 2 1 0 2 2 2 0 RTX toxin acyltransferase family Pathogen_betaC1 PF09593.10 ETO02525.1 - 0.035 14.0 0.8 0.084 12.8 0.7 1.7 1 1 0 1 1 1 0 Beta-satellite pathogenicity beta C1 protein DUF1779 PF08680.10 ETO02525.1 - 0.17 12.1 5.9 0.27 11.4 0.6 2.1 1 1 1 2 2 2 0 TATA-box binding CAP_GLY PF01302.25 ETO02526.1 - 0.00055 19.9 0.0 0.0032 17.5 0.0 2.0 2 0 0 2 2 2 1 CAP-Gly domain NACHT PF05729.12 ETO02527.1 - 1.2e-06 28.5 0.0 3.2e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain JHD PF17811.1 ETO02527.1 - 0.008 16.7 0.1 0.033 14.7 0.1 2.1 1 0 0 1 1 1 1 Jumonji helical domain NLRC4_HD2 PF17776.1 ETO02527.1 - 0.053 14.1 0.1 0.41 11.2 0.0 2.6 2 0 0 2 2 2 0 NLRC4 helical domain HD2 Adaptin_N PF01602.20 ETO02528.1 - 0.005 15.5 0.9 0.0059 15.2 0.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region RasGEF_N PF00618.20 ETO02528.1 - 0.044 14.0 0.5 1.2 9.4 0.1 2.1 2 0 0 2 2 2 0 RasGEF N-terminal motif TetR_C_8 PF14278.6 ETO02528.1 - 0.049 13.7 0.5 0.79 9.9 0.0 2.3 1 1 0 2 2 2 0 Transcriptional regulator C-terminal region HEAT PF02985.22 ETO02529.1 - 3.4e-14 51.7 4.9 0.34 11.3 0.0 10.1 11 0 0 11 11 11 3 HEAT repeat HEAT_2 PF13646.6 ETO02529.1 - 3.2e-11 43.4 0.0 0.022 15.1 0.0 5.5 4 2 3 7 7 7 4 HEAT repeats HEAT_EZ PF13513.6 ETO02529.1 - 6.5e-10 39.3 0.0 4 8.0 0.0 8.5 8 1 1 9 9 9 2 HEAT-like repeat Cnd1 PF12717.7 ETO02529.1 - 1.5e-07 31.6 24.6 0.0014 18.7 0.5 5.8 2 2 4 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO02529.1 - 6.4e-06 26.7 18.2 0.015 15.8 0.1 6.7 3 2 3 6 6 6 1 Vacuolar 14 Fab1-binding region Ank_3 PF13606.6 ETO02529.1 - 0.0044 17.4 0.3 0.092 13.4 0.0 3.3 2 1 1 3 3 2 1 Ankyrin repeat RTP1_C1 PF10363.9 ETO02529.1 - 0.013 15.7 9.1 11 6.3 0.0 5.3 4 1 1 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 BP28CT PF08146.12 ETO02529.1 - 0.042 13.7 8.8 0.15 11.9 0.2 4.7 3 1 1 4 4 4 0 BP28CT (NUC211) domain DNA_alkylation PF08713.11 ETO02529.1 - 0.064 13.0 3.3 3.4 7.3 0.2 3.2 3 1 0 3 3 3 0 DNA alkylation repair enzyme FPL PF09758.9 ETO02529.1 - 0.07 13.1 13.3 0.14 12.1 3.2 4.7 4 0 0 4 4 4 0 Uncharacterised conserved protein Ank_2 PF12796.7 ETO02529.1 - 0.076 13.6 0.2 3.6 8.3 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeats (3 copies) HEAT_PBS PF03130.16 ETO02529.1 - 0.19 12.5 0.0 1.9e+02 3.2 0.0 4.1 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat ALMT PF11744.8 ETO02530.1 - 0.00022 20.2 1.7 0.00036 19.5 1.7 1.3 1 0 0 1 1 1 1 Aluminium activated malate transporter WD40 PF00400.32 ETO02531.1 - 8.9e-13 48.5 12.0 5.7e-06 27.0 1.0 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO02531.1 - 2.2e-06 26.6 1.0 0.025 13.2 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02531.1 - 0.0028 17.9 0.1 0.14 12.5 0.0 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Neur_chan_memb PF02932.16 ETO02532.1 - 5.7 6.9 11.7 6.7 6.7 11.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ras PF00071.22 ETO02534.1 - 1.7e-11 44.0 0.4 5e-11 42.5 0.0 1.9 2 1 0 2 2 2 1 Ras family mRNA_stabil PF13929.6 ETO02535.1 - 0.0068 15.4 1.0 0.0077 15.2 1.0 1.0 1 0 0 1 1 1 1 mRNA stabilisation Clusterin PF01093.17 ETO02535.1 - 0.032 13.3 0.1 0.032 13.3 0.1 1.1 1 0 0 1 1 1 0 Clusterin SPRY PF00622.28 ETO02536.1 - 7.5e-06 26.1 0.1 1.2e-05 25.4 0.1 1.4 1 0 0 1 1 1 1 SPRY domain zf-RING_5 PF14634.6 ETO02537.1 - 0.026 14.5 0.6 0.026 14.5 0.6 4.5 2 1 1 3 3 3 0 zinc-RING finger domain FYVE PF01363.21 ETO02537.1 - 0.16 12.2 14.6 3 8.0 0.5 4.4 4 1 0 4 4 4 0 FYVE zinc finger Prok-RING_4 PF14447.6 ETO02537.1 - 0.19 11.6 0.4 0.19 11.6 0.4 3.7 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-C2H2_3 PF13878.6 ETO02537.1 - 0.24 11.2 2.1 2.9 7.8 0.0 3.1 3 0 0 3 3 3 0 zinc-finger of acetyl-transferase ESCO CTU2 PF10288.9 ETO02537.1 - 0.25 11.6 5.3 0.28 11.5 1.2 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 Rpr2 PF04032.16 ETO02537.1 - 2 8.7 7.7 2.3 8.6 3.4 2.9 2 1 0 2 2 2 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain zf-RING_5 PF14634.6 ETO02538.1 - 0.016 15.2 11.2 0.071 13.1 5.8 3.1 2 1 0 2 2 2 0 zinc-RING finger domain Rpr2 PF04032.16 ETO02538.1 - 0.11 12.7 6.0 1.3 9.4 1.8 3.1 2 1 1 3 3 3 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain WD40 PF00400.32 ETO02539.1 - 0.0041 17.9 1.0 0.022 15.6 0.1 2.2 2 1 0 2 2 2 1 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO02539.1 - 0.072 13.1 0.1 0.26 11.3 0.1 1.8 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region Macoilin PF09726.9 ETO02542.1 - 0.11 11.1 15.6 0.12 10.9 15.6 1.0 1 0 0 1 1 1 0 Macoilin family PPP4R2 PF09184.11 ETO02542.1 - 2.9 7.4 21.6 0.7 9.4 0.1 2.2 1 1 1 2 2 2 0 PPP4R2 Hid1 PF12722.7 ETO02542.1 - 7.6 4.5 12.3 9 4.3 12.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CUE PF02845.16 ETO02543.1 - 0.022 14.5 0.0 0.05 13.3 0.0 1.6 1 0 0 1 1 1 0 CUE domain IFT81_CH PF18383.1 ETO02543.1 - 0.029 14.6 4.9 0.73 10.1 0.2 3.0 2 2 1 3 3 3 0 Intraflagellar transport 81 calponin homology domain PBP_GOBP PF01395.22 ETO02543.1 - 0.075 13.2 3.4 0.11 12.7 0.4 2.5 1 1 1 2 2 2 0 PBP/GOBP family His_Phos_1 PF00300.22 ETO02544.1 - 1.1e-05 25.2 0.0 1.6e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) UPF0239 PF06783.11 ETO02545.1 - 0.035 14.3 0.0 0.05 13.8 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) SRTM1 PF15872.5 ETO02545.1 - 0.082 13.1 0.0 0.094 12.9 0.0 1.1 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 WD40 PF00400.32 ETO02546.1 - 6.7e-09 36.2 0.2 0.0023 18.7 0.0 2.6 3 0 0 3 3 3 2 WD domain, G-beta repeat eIF2A PF08662.11 ETO02546.1 - 0.00015 21.7 1.6 0.00033 20.6 1.3 1.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Str_synth PF03088.16 ETO02546.1 - 0.0087 16.2 0.2 0.016 15.3 0.2 1.4 1 0 0 1 1 1 1 Strictosidine synthase ANAPC4_WD40 PF12894.7 ETO02546.1 - 0.034 14.4 0.0 0.3 11.4 0.0 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Exostosin PF03016.15 ETO02546.1 - 0.078 12.2 0.0 0.095 11.9 0.0 1.1 1 0 0 1 1 1 0 Exostosin family Phage_Gp23 PF10669.9 ETO02551.1 - 0.027 14.8 11.0 0.03 14.7 11.0 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) AP3D1 PF06375.11 ETO02551.1 - 1.8 8.7 14.4 1.6 9.0 14.4 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Peptidase_S49_N PF08496.10 ETO02551.1 - 3.2 7.8 11.5 2.9 8.0 11.5 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EF-hand_1 PF00036.32 ETO02553.1 - 8.5e-09 34.4 7.6 9.6e-05 21.7 0.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO02553.1 - 8e-08 32.6 1.2 0.0037 17.7 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO02553.1 - 1.6e-07 30.7 4.0 0.006 16.4 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO02553.1 - 5.8e-06 26.1 6.3 0.0068 16.2 0.4 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO02553.1 - 0.00027 20.3 3.4 0.039 13.4 0.2 2.6 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 ETO02553.1 - 0.00053 19.9 3.0 0.11 12.4 0.3 2.5 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Phostensin_N PF13916.6 ETO02553.1 - 0.24 11.8 0.1 0.24 11.8 0.1 2.1 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal DUF3381 PF11861.8 ETO02553.1 - 3.9 7.3 9.8 27 4.5 7.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Colicin_im PF03857.13 ETO02554.1 - 0.0078 16.2 0.2 0.01 15.8 0.2 1.2 1 0 0 1 1 1 1 Colicin immunity protein zf-TRAF PF02176.18 ETO02557.1 - 4.4e-06 27.3 2.7 4.4e-06 27.3 2.7 2.9 2 1 0 2 2 2 1 TRAF-type zinc finger TMF_TATA_bd PF12325.8 ETO02557.1 - 0.085 13.1 0.3 2.3 8.4 0.2 2.5 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding zf-C3HC4 PF00097.25 ETO02557.1 - 0.97 9.4 6.1 13 5.8 0.2 3.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF755 PF05501.11 ETO02557.1 - 1.7 8.9 6.6 0.23 11.8 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF755) tRNA_synt_2f PF02092.17 ETO02559.1 - 2.9e-56 191.5 0.0 3.4e-56 191.3 0.0 1.0 1 0 0 1 1 1 1 Glycyl-tRNA synthetase beta subunit Tudor-knot PF11717.8 ETO02560.1 - 0.0066 16.3 2.1 0.018 14.9 2.1 1.7 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain Glyco_trans_1_2 PF13524.6 ETO02560.1 - 0.11 12.9 0.4 0.18 12.2 0.4 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 DUF5097 PF17020.5 ETO02561.1 - 0.033 14.5 0.0 0.045 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) Actin PF00022.19 ETO02561.1 - 0.069 11.8 0.0 0.076 11.6 0.0 1.1 1 0 0 1 1 1 0 Actin Chordopox_RPO7 PF05864.12 ETO02562.1 - 0.5 10.7 4.5 0.5 10.6 0.4 2.2 1 1 1 2 2 2 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) Crust_neurohorm PF01147.17 ETO02565.1 - 0.066 13.0 3.7 0.13 12.1 1.5 2.7 2 1 0 2 2 2 0 Crustacean CHH/MIH/GIH neurohormone family zf-C2H2_9 PF16293.5 ETO02565.1 - 0.099 12.5 0.5 0.8 9.6 0.0 2.6 2 0 0 2 2 2 0 C2H2 type zinc-finger (1 copy) Kinesin PF00225.23 ETO02566.1 - 1.8e-27 96.2 0.3 2.6e-27 95.7 0.3 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO02566.1 - 2.7e-13 50.1 0.2 6.8e-13 48.8 0.2 1.6 1 0 0 1 1 1 1 Microtubule binding zf-TFIIB PF13453.6 ETO02567.1 - 0.0026 17.0 0.3 0.0057 15.9 0.3 1.6 1 0 0 1 1 1 1 Transcription factor zinc-finger CUE PF02845.16 ETO02568.1 - 0.088 12.5 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 CUE domain DUF836 PF05768.14 ETO02568.1 - 0.18 12.2 1.6 2.5 8.6 0.1 2.6 3 0 0 3 3 3 0 Glutaredoxin-like domain (DUF836) EIIBC-GUT_N PF03612.14 ETO02571.1 - 1.4 8.7 10.0 1.6 8.5 10.0 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Syntaxin_2 PF14523.6 ETO02572.1 - 0.0028 18.0 4.7 0.0028 18.0 4.7 2.1 1 1 1 2 2 2 1 Syntaxin-like protein DUF4522 PF15022.6 ETO02572.1 - 0.031 14.5 3.0 0.031 14.5 3.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4522) YL1 PF05764.13 ETO02573.1 - 0.56 10.3 22.9 0.68 10.0 22.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein MPTase-PolyVal PF18818.1 ETO02574.1 - 0.011 15.8 0.1 0.018 15.1 0.1 1.3 1 0 0 1 1 1 0 Metallopeptidase superfamily domain KIND PF16474.5 ETO02574.1 - 0.047 13.6 0.2 0.097 12.6 0.0 1.5 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain DUF3891 PF13030.6 ETO02575.1 - 0.14 11.9 0.0 0.14 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) Glyco_transf_5 PF08323.11 ETO02576.1 - 0.037 13.7 0.1 0.067 12.9 0.0 1.5 1 1 0 1 1 1 0 Starch synthase catalytic domain DUF2393 PF09624.10 ETO02577.1 - 0.085 12.8 2.1 4.4 7.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) LCAT PF02450.15 ETO02578.1 - 0.026 13.7 2.5 0.057 12.6 2.5 1.5 1 1 0 1 1 1 0 Lecithin:cholesterol acyltransferase DUF1018 PF06252.12 ETO02579.1 - 0.015 16.3 6.1 0.051 14.6 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1018) DUF4375 PF14300.6 ETO02579.1 - 0.05 13.9 4.3 0.058 13.7 2.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4375) SUIM_assoc PF16619.5 ETO02580.1 - 0.009 16.1 6.6 0.009 16.1 6.6 1.9 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 PXA PF02194.15 ETO02580.1 - 0.041 13.9 0.2 0.062 13.3 0.2 1.3 1 0 0 1 1 1 0 PXA domain SID-1_RNA_chan PF13965.6 ETO02580.1 - 0.068 11.6 0.0 0.087 11.2 0.0 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PB1 PF00564.24 ETO02581.1 - 0.0032 17.4 0.3 0.0042 17.0 0.3 1.2 1 0 0 1 1 1 1 PB1 domain UN_NPL4 PF11543.8 ETO02581.1 - 0.007 16.8 0.1 0.0079 16.7 0.1 1.2 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 DUF3164 PF11363.8 ETO02581.1 - 0.028 14.1 0.0 0.035 13.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3164) DED PF01335.21 ETO02581.1 - 0.03 14.6 0.3 0.041 14.2 0.3 1.2 1 0 0 1 1 1 0 Death effector domain RPW8 PF05659.11 ETO02583.1 - 0.03 14.0 2.1 0.032 13.9 1.5 1.3 1 1 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Flp_N PF03930.14 ETO02583.1 - 0.09 12.8 2.0 0.17 11.8 0.2 2.0 1 1 1 2 2 2 0 Recombinase Flp protein N-terminus FAM75 PF14650.6 ETO02585.1 - 0.091 12.3 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 FAM75 family ABC_tran PF00005.27 ETO02586.1 - 1.7e-12 48.0 0.0 1.9e-12 47.9 0.0 1.0 1 0 0 1 1 1 1 ABC transporter TPR_12 PF13424.6 ETO02587.1 - 1e-64 214.8 18.2 7.6e-21 74.2 0.8 4.0 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02587.1 - 8.8e-36 120.8 10.3 9.6e-09 34.8 0.0 6.3 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02587.1 - 1.5e-35 119.6 45.1 1e-09 37.8 0.7 6.7 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02587.1 - 1.8e-32 108.8 30.2 9e-08 31.7 0.7 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02587.1 - 6e-24 82.3 11.6 7.2e-05 22.5 0.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02587.1 - 7.7e-21 72.5 35.3 2.2e-07 30.5 0.3 6.4 6 1 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02587.1 - 3e-18 66.2 0.0 2.3e-06 28.2 0.0 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02587.1 - 4.9e-15 55.1 3.5 0.033 14.8 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02587.1 - 8.1e-14 51.0 46.2 0.00019 21.1 0.4 8.9 6 3 3 9 9 9 6 TPR repeat TPR_17 PF13431.6 ETO02587.1 - 3.7e-13 48.9 21.2 0.0014 18.9 2.1 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02587.1 - 1.7e-12 47.0 0.0 0.45 11.5 0.0 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat SNAP PF14938.6 ETO02587.1 - 2e-12 47.2 15.2 1.4e-09 37.8 3.3 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 ETO02587.1 - 9e-08 32.5 4.7 0.0059 17.1 0.8 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO02587.1 - 9.1e-08 32.2 23.0 0.0036 17.5 4.9 5.0 3 1 2 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 ETO02587.1 - 1e-05 25.4 21.8 0.001 18.9 2.7 3.8 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_5 PF12688.7 ETO02587.1 - 2.6e-05 24.5 0.2 0.065 13.5 0.0 3.4 2 1 1 3 3 3 1 Tetratrico peptide repeat TPR_3 PF07720.12 ETO02587.1 - 6.1e-05 22.9 28.5 0.0086 16.1 1.2 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO02587.1 - 0.0003 20.2 6.6 0.68 9.4 0.2 4.3 5 0 0 5 5 4 2 SHNi-TPR HTH_Bact PF18768.1 ETO02587.1 - 0.00034 20.1 2.1 0.86 9.2 0.0 4.2 4 0 0 4 4 4 1 Helix-turn-helix bacterial domain PPR PF01535.20 ETO02587.1 - 0.00065 19.8 7.7 0.71 10.3 0.4 5.4 6 1 1 7 7 6 1 PPR repeat MIT PF04212.18 ETO02587.1 - 0.0015 18.5 21.8 1.9 8.6 0.3 6.0 6 0 0 6 6 6 1 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 ETO02587.1 - 0.0033 18.0 10.5 15 6.5 0.0 5.5 6 0 0 6 6 5 0 Sel1 repeat TetR_C_19 PF17924.1 ETO02587.1 - 0.0038 17.8 6.6 1.4 9.5 0.3 3.8 3 0 0 3 3 3 1 Tetracyclin repressor-like, C-terminal domain TPR_MalT PF17874.1 ETO02587.1 - 0.015 14.7 0.0 2.1 7.6 0.0 2.6 1 1 2 3 3 3 0 MalT-like TPR region Mob_Pre PF01076.19 ETO02587.1 - 0.018 14.9 17.0 0.068 13.0 10.4 2.3 1 1 1 2 2 2 0 Plasmid recombination enzyme Goodbye PF17109.5 ETO02587.1 - 0.026 15.0 1.9 6.6 7.2 0.0 3.2 3 0 0 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF1896 PF08989.10 ETO02587.1 - 0.033 14.3 6.4 0.055 13.6 0.2 3.6 2 1 3 5 5 4 0 Domain of unknown function (DUF1896) Rapsyn_N PF10579.9 ETO02587.1 - 0.039 14.1 3.3 45 4.2 0.1 4.4 4 1 1 5 5 4 0 Rapsyn N-terminal myristoylation and linker region DUF5113 PF17140.4 ETO02587.1 - 0.15 11.9 26.2 3.4 7.5 0.2 5.2 5 1 1 6 6 6 0 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETO02587.1 - 0.36 10.5 16.4 4.9 6.8 0.3 4.5 1 1 2 3 3 3 0 26S proteasome subunit RPN7 Vps39_1 PF10366.9 ETO02587.1 - 1.8 8.9 14.2 5.6 7.3 0.3 4.4 1 1 4 5 5 5 0 Vacuolar sorting protein 39 domain 1 Prefoldin PF02996.17 ETO02587.1 - 1.8 8.5 12.4 1.1 9.2 0.6 4.1 3 2 2 5 5 5 0 Prefoldin subunit PPR_2 PF13041.6 ETO02587.1 - 2.1 8.6 15.3 2 8.7 0.2 5.0 6 0 0 6 6 6 0 PPR repeat family NSF PF02071.20 ETO02587.1 - 3.7 8.7 21.8 25 6.2 0.1 6.7 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat NuA4 PF09340.10 ETO02587.1 - 7.1 6.6 9.4 0.41 10.6 1.3 2.8 2 1 1 3 3 2 0 Histone acetyltransferase subunit NuA4 DUF5344 PF17279.2 ETO02587.1 - 7.5 7.2 12.8 7.5 7.2 2.0 4.2 2 1 2 4 4 4 0 Family of unknown function (DUF5344) UCH PF00443.29 ETO02588.1 - 0.047 13.2 3.7 0.076 12.5 3.8 1.6 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase SPRY PF00622.28 ETO02589.1 - 2.7e-14 53.3 0.4 5.5e-14 52.3 0.4 1.6 1 0 0 1 1 1 1 SPRY domain zf-RanBP PF00641.18 ETO02589.1 - 0.0057 16.0 7.7 0.015 14.6 7.7 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others WD40 PF00400.32 ETO02590.1 - 6e-12 45.9 1.7 6.8e-05 23.6 0.0 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat DUF3637 PF12337.8 ETO02590.1 - 0.046 14.0 0.1 0.082 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3637) Nup160 PF11715.8 ETO02590.1 - 0.078 11.6 0.0 4.7 5.7 0.0 2.1 2 0 0 2 2 2 0 Nucleoporin Nup120/160 Abhydrolase_2 PF02230.16 ETO02593.1 - 5.1e-15 55.9 0.0 7.2e-15 55.4 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 ETO02593.1 - 0.00049 19.6 0.0 0.00066 19.2 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ETO02593.1 - 0.00072 19.2 0.0 0.00098 18.7 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ETO02593.1 - 0.0024 17.2 0.1 0.044 13.1 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 FSH1 PF03959.13 ETO02593.1 - 0.025 14.3 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Neur_chan_memb PF02932.16 ETO02593.1 - 0.14 12.2 0.4 0.15 12.1 0.4 1.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Abhydrolase_4 PF08386.10 ETO02593.1 - 0.19 11.8 0.0 0.27 11.3 0.0 1.2 1 0 0 1 1 1 0 TAP-like protein DHHC PF01529.20 ETO02593.1 - 8.3 6.5 7.2 12 6.0 7.2 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase RL PF17797.1 ETO02594.1 - 0.077 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 RL domain DUF1459 PF07312.11 ETO02594.1 - 1.1 9.5 6.0 2.4 8.4 6.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1459) Mannosyl_trans3 PF11051.8 ETO02596.1 - 1.7e-06 27.6 0.0 2.4e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Sulfatase PF00884.23 ETO02597.1 - 0.11 11.9 1.8 1.5 8.2 0.0 2.2 1 1 1 2 2 2 0 Sulfatase Ras PF00071.22 ETO02598.1 - 8.4e-24 84.0 0.0 1.2e-23 83.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO02598.1 - 0.0003 21.0 0.1 0.0013 18.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF3744 PF12558.8 ETO02598.1 - 0.013 16.2 0.3 0.013 16.2 0.3 1.9 2 0 0 2 2 2 0 ATP-binding cassette cobalt transporter Arf PF00025.21 ETO02598.1 - 0.03 13.8 0.0 0.043 13.3 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family DUF5448 PF17526.2 ETO02599.1 - 0.049 13.8 4.0 0.06 13.5 0.8 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5448) FOXP-CC PF16159.5 ETO02599.1 - 0.091 13.4 6.7 0.53 10.9 0.4 3.3 3 0 0 3 3 3 0 FOXP coiled-coil domain Ran_BP1 PF00638.18 ETO02600.1 - 3.5e-06 27.3 0.1 6.8e-06 26.4 0.1 1.4 1 0 0 1 1 1 1 RanBP1 domain DUF4611 PF15387.6 ETO02600.1 - 0.012 15.8 5.5 0.012 15.8 5.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) NPV_P10 PF05531.12 ETO02600.1 - 0.067 13.7 1.0 0.097 13.2 0.2 1.7 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DASH_Dam1 PF08653.10 ETO02600.1 - 0.076 12.8 0.1 0.21 11.4 0.1 1.8 1 0 0 1 1 1 0 DASH complex subunit Dam1 FAM176 PF14851.6 ETO02600.1 - 0.19 11.4 5.8 0.23 11.1 0.6 2.4 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 ETO02600.1 - 1.5 8.0 15.1 1.8 7.8 9.2 2.0 2 0 0 2 2 2 0 BUD22 RP-C_C PF11800.8 ETO02600.1 - 3.4 7.7 7.1 0.61 10.1 1.7 1.9 2 0 0 2 2 2 0 Replication protein C C-terminal region Vfa1 PF08432.10 ETO02600.1 - 3.8 7.8 10.8 1.4 9.2 4.2 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DASH_Spc19 PF08287.11 ETO02600.1 - 8.8 6.2 7.5 2.1 8.2 3.0 1.9 2 0 0 2 2 2 0 Spc19 DHHC PF01529.20 ETO02602.1 - 2.9e-31 108.3 6.9 2.9e-31 108.3 6.9 2.8 2 1 0 2 2 2 1 DHHC palmitoyltransferase ADH_N PF08240.12 ETO02602.1 - 1.1 9.1 7.0 1.1 9.2 4.6 2.1 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain Kelch_2 PF07646.15 ETO02603.1 - 1.1e-07 31.5 0.5 0.00081 19.3 0.3 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO02603.1 - 7.9e-07 28.6 0.1 4.8e-05 22.8 0.2 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO02603.1 - 2.1e-05 24.7 0.2 0.21 11.9 0.2 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO02603.1 - 4.1e-05 23.5 0.0 0.0033 17.4 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO02603.1 - 0.028 14.4 0.0 0.22 11.6 0.2 2.1 2 0 0 2 2 2 0 Kelch motif CTP_transf_1 PF01148.20 ETO02603.1 - 0.08 12.7 0.0 0.094 12.5 0.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family NYD-SP28_assoc PF14775.6 ETO02604.1 - 0.022 14.8 2.7 0.038 14.1 2.2 1.8 1 1 0 1 1 1 0 Sperm tail C-terminal domain Atg14 PF10186.9 ETO02604.1 - 0.49 9.4 11.9 0.47 9.5 11.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RF-1 PF00472.20 ETO02604.1 - 0.81 9.6 11.6 1.2 9.1 11.6 1.4 1 1 0 1 1 1 0 RF-1 domain Imm70 PF15601.6 ETO02605.1 - 0.008 15.7 0.3 1.1 8.8 0.1 3.0 3 0 0 3 3 3 1 Immunity protein 70 DUF2757 PF10955.8 ETO02605.1 - 0.028 14.7 2.4 0.21 11.9 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2757) DUF3944 PF13099.6 ETO02605.1 - 0.036 13.9 2.3 0.13 12.1 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3944) MA3 PF02847.17 ETO02605.1 - 0.18 11.8 2.8 0.25 11.4 0.4 2.5 2 1 1 3 3 3 0 MA3 domain Fe-S_assembly PF04384.13 ETO02606.1 - 0.048 14.3 1.7 0.073 13.7 0.3 2.1 2 0 0 2 2 2 0 Iron-sulphur cluster assembly Arm PF00514.23 ETO02607.1 - 0.00031 20.7 0.0 0.0027 17.7 0.0 2.7 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ETO02607.1 - 0.0018 18.3 1.5 0.037 14.0 0.1 2.8 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain COX2_TM PF02790.15 ETO02607.1 - 0.77 10.0 5.1 2.6 8.3 0.3 2.7 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain FSAP_sig_propep PF03032.15 ETO02607.1 - 8 6.6 10.3 34 4.6 10.3 2.1 1 1 0 1 1 1 0 Frog skin active peptide family signal and propeptide DUF1746 PF08508.10 ETO02607.1 - 8.8 6.7 11.5 1.6 9.1 1.8 3.4 3 1 1 4 4 4 0 Fungal domain of unknown function (DUF1746) Ada3 PF10198.9 ETO02608.1 - 0.23 11.6 1.1 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 Histone acetyltransferases subunit 3 Peptidase_M1_N PF17900.1 ETO02609.1 - 4.4e-21 75.9 0.4 6.9e-21 75.3 0.4 1.2 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain T3SS_needle_F PF09392.10 ETO02613.1 - 0.22 11.7 2.9 4.1 7.7 0.5 2.3 2 1 0 2 2 2 0 Type III secretion needle MxiH, YscF, SsaG, EprI, PscF, EscF DUF4268 PF14088.6 ETO02613.1 - 0.9 9.4 9.8 10 6.0 9.8 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4268) Membralin PF09746.9 ETO02614.1 - 0.28 10.2 5.7 0.3 10.1 5.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO02614.1 - 0.28 9.9 2.8 0.31 9.8 2.8 1.1 1 0 0 1 1 1 0 Presenilin DUF2951 PF11166.8 ETO02614.1 - 2 8.7 7.0 2.7 8.3 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) YqfQ PF14181.6 ETO02614.1 - 5 7.3 9.9 6.5 6.9 9.9 1.1 1 0 0 1 1 1 0 YqfQ-like protein RVT_1 PF00078.27 ETO02615.1 - 8.9e-08 31.9 0.1 1.1e-07 31.6 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) AgrD PF05931.11 ETO02615.1 - 6.2 6.9 6.7 1.7 8.7 0.6 2.5 2 1 0 2 2 2 0 Staphylococcal AgrD protein Kelch_2 PF07646.15 ETO02616.1 - 1.1e-06 28.4 0.4 0.00026 20.8 0.1 2.5 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO02616.1 - 4.5e-06 26.1 0.1 0.00015 21.3 0.0 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO02616.1 - 2e-05 24.5 0.1 0.00059 19.8 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO02616.1 - 0.00044 20.4 0.2 0.21 12.0 0.2 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO02616.1 - 0.0012 18.8 0.1 0.015 15.3 0.3 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO02616.1 - 0.0075 16.5 0.0 0.15 12.4 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Mpp10 PF04006.12 ETO02617.1 - 1.5 7.2 34.6 1.5 7.2 34.6 1.1 1 0 0 1 1 1 0 Mpp10 protein Presenilin PF01080.17 ETO02617.1 - 4.5 5.9 9.7 4.7 5.9 9.7 1.1 1 0 0 1 1 1 0 Presenilin Alg14 PF08660.11 ETO02618.1 - 0.15 12.0 0.1 0.18 11.7 0.1 1.2 1 0 0 1 1 1 0 Oligosaccharide biosynthesis protein Alg14 like DUF3960 PF13142.6 ETO02618.1 - 0.51 10.5 4.3 0.95 9.6 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3960) Peptidase_C48 PF02902.19 ETO02619.1 - 1e-18 68.0 3.7 1.1e-18 67.9 3.7 1.0 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 ETO02619.1 - 0.0021 16.9 5.1 0.18 10.5 1.0 2.1 1 1 1 2 2 2 2 Vaccinia virus I7 processing peptidase Peptidase_C5 PF00770.18 ETO02619.1 - 0.86 9.2 3.9 5 6.8 1.9 2.0 1 1 1 2 2 2 0 Adenovirus endoprotease zf-C3HC4_2 PF13923.6 ETO02621.1 - 1.2 9.0 8.4 6.5 6.7 5.3 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TMF_DNA_bd PF12329.8 ETO02625.1 - 0.021 14.8 9.5 0.051 13.6 9.5 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding P4Ha_N PF08336.11 ETO02625.1 - 0.038 14.0 3.3 0.087 12.8 3.3 1.6 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region zf-C2HE PF16278.5 ETO02625.1 - 0.058 13.8 1.7 0.058 13.8 1.7 2.4 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger DUF4407 PF14362.6 ETO02625.1 - 0.065 12.6 1.7 0.078 12.3 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ETO02625.1 - 0.078 11.8 11.0 0.11 11.4 11.0 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF641 PF04859.12 ETO02625.1 - 0.11 12.9 5.5 0.15 12.4 3.3 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CC2-LZ PF16516.5 ETO02625.1 - 0.2 12.0 11.0 0.24 11.8 9.3 1.9 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator YscO-like PF16789.5 ETO02625.1 - 0.2 11.7 10.3 0.95 9.5 10.3 1.9 1 1 0 1 1 1 0 YscO-like protein Tropomyosin_1 PF12718.7 ETO02625.1 - 0.22 11.7 13.0 0.054 13.6 6.8 2.4 1 1 0 2 2 2 0 Tropomyosin like DUF948 PF06103.11 ETO02625.1 - 0.37 11.1 4.2 0.73 10.1 4.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FAM76 PF16046.5 ETO02625.1 - 0.38 10.1 18.4 0.54 9.6 18.4 1.3 1 1 0 1 1 1 0 FAM76 protein Laminin_II PF06009.12 ETO02625.1 - 0.46 10.5 10.1 0.72 9.9 9.7 1.6 1 1 0 1 1 1 0 Laminin Domain II DUF724 PF05266.14 ETO02625.1 - 0.75 9.6 11.7 0.11 12.4 6.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 ETO02625.1 - 1.6 8.8 13.9 4.5 7.3 13.9 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 ETO02625.1 - 2.8 8.5 14.2 5.9 7.4 13.6 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 DUF1664 PF07889.12 ETO02625.1 - 3.2 7.8 8.3 10 6.2 2.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) NPV_P10 PF05531.12 ETO02625.1 - 3.3 8.2 13.1 16 6.1 11.9 2.3 2 1 0 2 2 1 0 Nucleopolyhedrovirus P10 protein SlyX PF04102.12 ETO02625.1 - 3.9 8.1 8.4 14 6.3 5.9 2.3 1 1 1 2 2 2 0 SlyX TMPIT PF07851.13 ETO02625.1 - 4.1 6.6 11.0 1.3 8.2 7.5 1.7 1 1 0 1 1 1 0 TMPIT-like protein Cys_rich_VLP PF14194.6 ETO02626.1 - 0.026 14.7 0.5 0.049 13.8 0.5 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP MCM6_C PF18263.1 ETO02627.1 - 4.9e-10 39.6 5.5 1e-09 38.6 5.5 1.5 1 1 0 1 1 1 1 MCM6 C-terminal winged-helix domain Innexin PF00876.18 ETO02627.1 - 0.018 14.3 0.6 0.022 14.0 0.6 1.0 1 0 0 1 1 1 0 Innexin Med6 PF04934.14 ETO02628.1 - 0.028 14.2 0.2 0.043 13.6 0.2 1.4 1 0 0 1 1 1 0 MED6 mediator sub complex component NACHT PF05729.12 ETO02629.1 - 1.5e-18 67.3 0.0 3.6e-18 66.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO02629.1 - 0.00026 20.3 0.9 0.0016 17.7 0.9 2.4 1 1 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ETO02629.1 - 0.0048 17.3 0.0 0.013 15.9 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain SMC_N PF02463.19 ETO02629.1 - 0.033 13.6 0.0 0.033 13.6 0.0 2.8 3 1 1 4 4 4 0 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 ETO02629.1 - 0.063 12.7 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI EOS1 PF12326.8 ETO02630.1 - 5.1 7.0 5.3 8.2 6.3 5.3 1.5 1 1 0 1 1 1 0 N-glycosylation protein Choline_transpo PF04515.12 ETO02631.1 - 0.66 9.1 4.7 0.85 8.8 4.7 1.3 1 1 0 1 1 1 0 Plasma-membrane choline transporter Ank_5 PF13857.6 ETO02632.1 - 0.0052 17.1 0.0 0.018 15.4 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO02632.1 - 0.0094 16.5 0.7 0.14 12.8 0.2 3.0 3 0 0 3 3 3 1 Ankyrin repeats (many copies) CAP_GLY PF01302.25 ETO02633.1 - 1.1e-05 25.4 0.2 1.5e-05 25.0 0.1 1.4 1 1 0 1 1 1 1 CAP-Gly domain DAP PF15228.6 ETO02634.1 - 0.54 11.5 5.9 1.7 9.9 0.2 2.3 2 0 0 2 2 2 0 Death-associated protein NOA36 PF06524.12 ETO02635.1 - 2.4 7.4 14.4 2.3 7.4 14.4 1.0 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO02635.1 - 3.9 7.9 12.0 4.1 7.8 12.0 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cytomega_UL84 PF06284.11 ETO02635.1 - 6.3 5.1 6.3 6.7 5.0 6.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RRN3 PF05327.11 ETO02635.1 - 8.2 4.8 7.4 7.3 5.0 7.4 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 ETO02635.1 - 8.3 5.4 21.8 8.8 5.3 21.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Exo_endo_phos_2 PF14529.6 ETO02638.1 - 6.9e-07 29.1 0.1 6.9e-07 29.1 0.1 2.2 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase ArAE_2_N PF10337.9 ETO02638.1 - 0.043 12.8 0.9 0.093 11.7 0.9 1.6 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal TIP49_C PF17856.1 ETO02638.1 - 0.085 13.0 0.0 0.26 11.5 0.0 1.8 1 0 0 1 1 1 0 TIP49 AAA-lid domain SpmSyn_N PF17950.1 ETO02638.1 - 0.25 11.6 5.1 8.4 6.7 0.1 2.8 1 1 1 2 2 2 0 S-adenosylmethionine decarboxylase N -terminal Neur_chan_memb PF02932.16 ETO02638.1 - 1.5 8.8 7.0 0.2 11.7 2.4 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Phage_pRha PF09669.10 ETO02638.1 - 5.6 7.6 10.9 0.87 10.2 1.3 2.8 2 0 0 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) Exo_endo_phos_2 PF14529.6 ETO02639.1 - 0.0086 15.9 2.8 0.012 15.4 0.0 2.6 3 1 0 3 3 3 1 Endonuclease-reverse transcriptase DUF1499 PF07386.11 ETO02639.1 - 0.074 13.6 0.8 0.33 11.5 0.2 2.2 2 1 0 3 3 3 0 Protein of unknown function (DUF1499) Neur_chan_memb PF02932.16 ETO02639.1 - 1.8 8.5 5.6 2.8 8.0 5.4 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Elongin_A PF06881.11 ETO02639.1 - 3.7 8.1 17.4 8.6 6.9 8.5 2.9 1 1 1 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A ArAE_2_N PF10337.9 ETO02639.1 - 9.3 5.2 7.8 0.3 10.1 2.1 1.5 2 0 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal ARF7EP_C PF14949.6 ETO02640.1 - 0.12 12.9 7.9 0.15 12.7 7.9 1.3 1 1 0 1 1 1 0 ARF7 effector protein C-terminus Intein_splicing PF14890.6 ETO02640.1 - 0.45 10.5 5.0 0.47 10.4 5.0 1.1 1 0 0 1 1 1 0 Intein splicing domain DivIC PF04977.15 ETO02641.1 - 0.24 11.2 10.0 0.31 10.8 5.5 2.1 2 0 0 2 2 2 0 Septum formation initiator TMF_DNA_bd PF12329.8 ETO02641.1 - 0.44 10.6 14.4 0.47 10.5 8.6 2.1 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TH1 PF04858.13 ETO02642.1 - 0.0048 15.6 1.5 0.54 8.8 0.0 2.0 2 0 0 2 2 2 2 TH1 protein WD40 PF00400.32 ETO02644.1 - 1.7e-38 129.9 22.8 4.2e-07 30.6 1.2 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02644.1 - 1.6e-11 44.4 4.0 0.06 13.6 0.0 5.9 6 1 0 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02644.1 - 4e-08 32.4 14.4 0.048 12.3 0.0 6.4 2 1 4 7 7 7 3 Nucleoporin Nup120/160 Atg14 PF10186.9 ETO02644.1 - 0.015 14.4 16.3 0.025 13.7 16.3 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Macoilin PF09726.9 ETO02644.1 - 0.036 12.6 15.4 0.046 12.3 15.4 1.1 1 0 0 1 1 1 0 Macoilin family Exonuc_VII_L PF02601.15 ETO02644.1 - 0.037 13.6 9.5 0.057 13.0 9.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4349 PF14257.6 ETO02644.1 - 0.08 12.4 3.1 0.14 11.5 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF4533 PF15047.6 ETO02644.1 - 0.11 12.0 11.3 0.22 11.1 11.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) DUF848 PF05852.11 ETO02644.1 - 0.19 11.8 12.5 0.42 10.7 12.5 1.5 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) FapA PF03961.13 ETO02644.1 - 0.31 9.6 16.4 0.47 9.0 16.4 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A ATG16 PF08614.11 ETO02644.1 - 0.34 11.1 26.2 0.63 10.2 26.2 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 ETO02644.1 - 0.74 9.9 14.6 0.062 13.3 5.4 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) GCD14 PF08704.10 ETO02644.1 - 1.2 8.8 6.4 2.3 7.8 6.4 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit DUF3450 PF11932.8 ETO02644.1 - 1.3 8.3 14.9 2.2 7.5 14.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF641 PF04859.12 ETO02644.1 - 1.6 9.1 13.0 3.8 7.8 13.0 1.6 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) ALMT PF11744.8 ETO02644.1 - 1.9 7.2 14.2 2.9 6.6 14.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Allexi_40kDa PF05549.11 ETO02644.1 - 3 7.3 14.0 6.9 6.1 13.5 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein MCU PF04678.13 ETO02644.1 - 3.9 7.5 6.8 9.7 6.2 6.8 1.7 1 0 0 1 1 1 0 Mitochondrial calcium uniporter V_ATPase_I PF01496.19 ETO02644.1 - 5.4 4.8 14.9 7.8 4.3 14.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UCH PF00443.29 ETO02645.1 - 1.2e-05 25.0 1.3 0.00011 21.8 1.3 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO02645.1 - 0.069 12.7 0.9 0.094 12.3 0.9 1.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase PLA2_inh PF02988.15 ETO02646.1 - 0.68 10.6 5.6 0.38 11.5 1.1 2.6 2 1 1 3 3 3 0 Phospholipase A2 inhibitor TPR_2 PF07719.17 ETO02649.1 - 2.9e-09 36.3 3.1 0.0084 16.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02649.1 - 6.8e-09 35.2 6.3 0.00064 19.4 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02649.1 - 2.3e-07 30.5 4.2 0.033 14.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02649.1 - 2.1e-06 27.7 9.4 0.0016 18.7 1.2 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO02649.1 - 1.6e-05 25.4 0.1 0.0052 17.3 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02649.1 - 5.6e-05 22.9 0.1 2.8 8.2 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02649.1 - 0.0001 22.7 1.3 9.2 7.1 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02649.1 - 0.00014 21.5 3.2 0.054 13.2 0.3 3.2 2 1 1 3 3 3 1 TPR repeat TPR_12 PF13424.6 ETO02649.1 - 0.0023 18.2 5.4 0.38 11.1 2.5 3.1 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO02649.1 - 0.0034 17.6 4.7 0.0058 16.8 4.7 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETO02649.1 - 0.028 15.2 0.0 1.2 10.1 0.0 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 ETO02649.1 - 0.55 10.3 4.4 13 5.9 0.4 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain zf-TRAF PF02176.18 ETO02650.1 - 1.2e-06 29.1 2.3 1.2e-06 29.1 2.3 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO02650.1 - 1.5 9.3 7.8 0.21 12.1 2.6 2.3 1 1 2 3 3 3 0 TRAF-like zinc-finger DUF1616 PF07760.11 ETO02652.1 - 0.0062 16.0 0.0 0.0099 15.3 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1616) DUF2207 PF09972.9 ETO02652.1 - 0.013 14.3 0.0 0.014 14.2 0.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2615 PF11027.8 ETO02652.1 - 0.023 14.8 2.3 1.4 9.1 0.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2615) DUF5305 PF17231.2 ETO02652.1 - 0.036 13.5 0.0 0.037 13.4 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5305) EphA2_TM PF14575.6 ETO02652.1 - 0.19 12.6 1.3 15 6.6 0.1 2.1 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain RSS_P20 PF11757.8 ETO02653.1 - 0.047 14.1 0.8 0.047 14.1 0.8 2.3 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain Fer2_4 PF13510.6 ETO02654.1 - 3.5e-20 71.8 0.6 6.3e-20 71.0 0.6 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain NADH-G_4Fe-4S_3 PF10588.9 ETO02654.1 - 8.1e-16 57.3 0.0 8.1e-16 57.3 0.0 2.1 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Fer2 PF00111.27 ETO02654.1 - 4.7e-11 42.5 0.5 4.7e-11 42.5 0.5 1.9 2 0 0 2 2 2 1 2Fe-2S iron-sulfur cluster binding domain Fer4_19 PF06902.11 ETO02654.1 - 0.12 12.5 1.5 17 5.6 0.0 2.8 2 0 0 2 2 2 0 Divergent 4Fe-4S mono-cluster Fer4 PF00037.27 ETO02654.1 - 0.71 9.8 6.9 1.7 8.6 0.4 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain Fer4_6 PF12837.7 ETO02654.1 - 4.5 7.5 8.1 0.45 10.7 0.7 3.1 3 0 0 3 3 3 0 4Fe-4S binding domain DUF4197 PF13852.6 ETO02658.1 - 0.014 15.0 0.6 0.021 14.5 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4197) ArAE_1_C PF11728.8 ETO02658.1 - 0.12 12.4 7.5 0.068 13.2 4.3 1.8 1 1 1 2 2 2 0 Putative aromatic acid exporter C-terminal domain DASH_Duo1 PF08651.10 ETO02658.1 - 0.21 11.4 9.7 0.12 12.2 5.1 2.5 1 1 2 3 3 3 0 DASH complex subunit Duo1 AI-2E_transport PF01594.16 ETO02658.1 - 1 8.4 5.2 1.3 8.1 5.2 1.2 1 0 0 1 1 1 0 AI-2E family transporter Glyco_hydro_47 PF01532.20 ETO02661.1 - 7.3e-54 183.4 6.1 1.7e-53 182.2 6.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 Ank_2 PF12796.7 ETO02663.1 - 0.0023 18.5 0.0 0.0071 16.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO02663.1 - 0.0036 17.7 0.1 1.3 9.9 0.0 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO02663.1 - 0.021 15.4 1.5 0.037 14.6 0.2 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) DUF4886 PF16227.5 ETO02663.1 - 0.031 13.5 0.4 0.12 11.6 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4886) Ank_5 PF13857.6 ETO02663.1 - 0.042 14.2 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) ubiquitin PF00240.23 ETO02664.1 - 7.6e-11 41.6 7.4 6.7e-05 22.6 0.7 5.0 3 2 0 3 3 3 2 Ubiquitin family DUF4457 PF14652.6 ETO02665.1 - 0.078 12.2 0.0 0.08 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4457) DUF4604 PF15377.6 ETO02665.1 - 0.15 12.4 9.8 0.18 12.3 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Sec62 PF03839.16 ETO02665.1 - 0.59 9.6 6.5 0.69 9.4 6.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 GOLD_2 PF13897.6 ETO02665.1 - 2.4 8.6 6.8 5.1 7.6 6.7 1.7 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking Cytomega_UL84 PF06284.11 ETO02665.1 - 2.5 6.5 5.2 2.4 6.5 5.2 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Presenilin PF01080.17 ETO02665.1 - 5.2 5.7 5.9 5.3 5.7 5.9 1.0 1 0 0 1 1 1 0 Presenilin Serum_albumin PF00273.20 ETO02666.1 - 0.017 14.9 0.0 0.031 14.0 0.0 1.4 1 0 0 1 1 1 0 Serum albumin family DUF1198 PF06711.11 ETO02666.1 - 0.077 13.1 0.2 1.7 8.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) AAA_32 PF13654.6 ETO02666.1 - 0.29 9.9 2.4 0.38 9.5 0.1 1.9 1 1 1 2 2 2 0 AAA domain FAM76 PF16046.5 ETO02667.1 - 0.79 9.0 6.1 0.056 12.8 0.4 1.8 2 0 0 2 2 2 0 FAM76 protein DUF3891 PF13030.6 ETO02668.1 - 0.042 13.6 0.1 0.068 12.9 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) Helicase_C PF00271.31 ETO02668.1 - 0.082 13.2 0.2 0.38 11.1 0.0 2.1 2 1 0 2 2 2 0 Helicase conserved C-terminal domain Topoisom_bac PF01131.20 ETO02670.1 - 2.9e-35 122.1 0.0 3.4e-35 121.9 0.0 1.0 1 0 0 1 1 1 1 DNA topoisomerase Nop52 PF05997.12 ETO02673.1 - 5.2e-43 147.3 0.6 6.6e-43 147.0 0.6 1.0 1 0 0 1 1 1 1 Nucleolar protein,Nop52 AAA PF00004.29 ETO02675.1 - 3e-05 24.4 1.0 0.0012 19.2 0.0 3.4 3 1 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO02675.1 - 0.00093 19.2 0.0 2.1 8.4 0.0 2.7 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO02675.1 - 0.015 15.5 0.0 0.52 10.6 0.0 3.3 2 1 0 2 2 2 0 AAA domain DUF440 PF04269.12 ETO02676.1 - 0.0034 17.7 0.4 0.0034 17.7 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function, DUF440 Peptidase_C11 PF03415.14 ETO02676.1 - 0.61 9.4 5.3 0.091 12.1 1.6 1.4 2 0 0 2 2 2 0 Clostripain family HTH_40 PF14493.6 ETO02677.1 - 0.3 11.6 2.3 0.84 10.1 0.2 2.8 2 1 1 3 3 3 0 Helix-turn-helix domain DUF1985 PF09331.11 ETO02678.1 - 0.0002 21.4 1.3 0.0003 20.8 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1985) DUF3989 PF13150.6 ETO02678.1 - 0.099 12.4 3.8 0.21 11.3 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3989) WD40 PF00400.32 ETO02679.1 - 0.035 15.0 0.4 0.065 14.1 0.4 1.4 1 0 0 1 1 1 0 WD domain, G-beta repeat RVT_1 PF00078.27 ETO02680.1 - 1.7e-35 122.6 1.7 1.7e-35 122.6 1.7 2.4 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) S_layer_N PF05123.12 ETO02680.1 - 0.0056 16.6 1.4 0.013 15.4 1.4 1.5 1 0 0 1 1 1 1 S-layer like family, N-terminal region DHC PF09626.10 ETO02680.1 - 0.034 15.0 0.5 0.034 15.0 0.5 2.5 2 1 0 2 2 2 0 Dihaem cytochrome c zf-RVT PF13966.6 ETO02680.1 - 0.08 13.7 1.8 0.2 12.4 0.2 2.6 2 0 0 2 2 2 0 zinc-binding in reverse transcriptase zf-MIZ PF02891.20 ETO02682.1 - 0.076 12.8 0.5 0.076 12.8 0.5 2.6 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 ETO02682.1 - 0.51 10.2 6.4 1.8 8.5 4.2 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cse1 PF08506.10 ETO02683.1 - 0.0021 16.9 6.9 1.2 7.9 0.3 3.5 2 2 2 4 4 4 3 Cse1 OrfB_IS605 PF01385.19 ETO02683.1 - 0.13 12.5 1.6 0.31 11.3 0.1 2.4 3 1 0 3 3 3 0 Probable transposase DUF1137 PF06587.11 ETO02683.1 - 0.21 11.6 3.2 7.5 6.6 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1137) KicB PF03882.14 ETO02683.1 - 0.71 10.1 5.2 19 5.5 0.0 3.9 1 1 2 4 4 4 0 MukF winged-helix domain Intg_mem_TP0381 PF09529.10 ETO02684.1 - 0.013 15.1 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) DUF4228 PF14009.6 ETO02684.1 - 0.062 13.7 2.0 0.11 12.9 2.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4228) DUF5568 PF17724.1 ETO02684.1 - 0.11 12.3 0.2 0.11 12.3 0.2 2.3 2 0 0 2 2 1 0 Family of unknown function (DUF5568) DUF1835 PF08874.10 ETO02684.1 - 0.25 11.5 3.2 0.22 11.7 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1835) TraV PF09676.10 ETO02684.1 - 0.31 12.0 4.2 0.27 12.2 0.6 2.0 2 0 0 2 2 2 0 Type IV conjugative transfer system lipoprotein (TraV) YL1 PF05764.13 ETO02684.1 - 1.2 9.2 29.4 0.92 9.6 16.6 2.2 2 0 0 2 2 2 0 YL1 nuclear protein NPR3 PF03666.13 ETO02684.1 - 1.3 7.7 16.1 0.02 13.7 5.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2115 PF09888.9 ETO02684.1 - 2.4 8.6 13.5 0.33 11.4 5.8 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) DcuA_DcuB PF03605.14 ETO02684.1 - 3.2 6.5 5.1 20 4.0 1.6 2.0 1 1 1 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Peroxin-13_N PF04088.13 ETO02684.1 - 3.7 7.8 8.7 2.3 8.5 3.8 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region RR_TM4-6 PF06459.12 ETO02684.1 - 7.3 6.3 19.0 5.3 6.8 11.7 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Kelch_5 PF13854.6 ETO02685.1 - 0.057 13.4 0.0 10 6.3 0.0 2.3 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO02686.1 - 8e-06 26.5 0.4 8e-06 26.5 0.4 2.8 3 1 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO02686.1 - 0.0033 16.2 0.3 0.0038 15.9 0.1 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Peptidase_M9 PF01752.17 ETO02687.1 - 0.16 11.2 0.0 0.19 10.9 0.0 1.1 1 0 0 1 1 1 0 Collagenase WD40 PF00400.32 ETO02688.1 - 4.7e-23 81.0 10.5 4.5e-06 27.3 0.1 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02688.1 - 2.7e-14 53.2 0.5 0.00071 19.8 0.0 4.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02688.1 - 9e-07 27.9 1.8 0.077 11.6 0.2 4.1 1 1 3 4 4 4 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO02688.1 - 0.00013 22.0 0.1 0.5 10.2 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETO02688.1 - 0.00015 20.7 6.0 0.17 10.6 1.2 3.4 1 1 2 3 3 3 3 Nup133 N terminal like Ge1_WD40 PF16529.5 ETO02688.1 - 0.00045 19.3 0.1 3.2 6.6 0.0 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO02688.1 - 0.0031 16.9 1.5 0.016 14.5 0.7 2.4 1 1 1 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO02688.1 - 0.0046 15.5 0.1 0.033 12.7 0.0 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO02688.1 - 0.0062 15.5 5.7 1.2 8.0 0.2 4.2 1 1 4 5 5 5 1 Partner and localizer of BRCA2 WD40 domain nos_propeller PF18764.1 ETO02688.1 - 0.0097 15.8 0.5 0.52 10.3 0.0 3.6 2 1 2 4 4 4 1 Nitrous oxide reductase propeller repeat Str_synth PF03088.16 ETO02688.1 - 0.054 13.6 0.1 3 8.0 0.0 2.9 1 1 2 3 3 3 0 Strictosidine synthase CHAP PF05257.16 ETO02688.1 - 0.15 12.7 0.0 3.3 8.3 0.0 2.4 2 0 0 2 2 2 0 CHAP domain Nop PF01798.18 ETO02691.1 - 2.7e-50 171.0 0.5 3.1e-50 170.8 0.5 1.0 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin WD40 PF00400.32 ETO02692.1 - 0.0036 18.1 0.9 0.015 16.2 0.1 2.2 2 1 0 2 2 2 1 WD domain, G-beta repeat Sina PF03145.16 ETO02693.1 - 0.00024 21.1 0.6 0.00027 20.9 0.6 1.1 1 0 0 1 1 1 1 Seven in absentia protein family Glyco_hydro_127 PF07944.12 ETO02694.1 - 2.5e-08 32.9 0.6 7.7e-07 28.0 0.1 2.1 2 0 0 2 2 2 2 Beta-L-arabinofuranosidase, GH127 Mob1_phocein PF03637.17 ETO02694.1 - 0.1 12.6 1.1 3.6 7.6 0.0 2.6 3 0 0 3 3 3 0 Mob1/phocein family RRN3 PF05327.11 ETO02695.1 - 6 5.3 18.8 7.4 5.0 18.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF1624 PF07786.12 ETO02697.1 - 0.083 12.4 1.8 1 8.9 0.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF1624) HET-S PF17108.5 ETO02697.1 - 0.22 11.3 0.3 0.39 10.5 0.3 1.3 1 0 0 1 1 1 0 N-terminal small S protein of HET, non-prionic WD40 PF00400.32 ETO02698.1 - 8.4e-19 67.6 7.5 0.00021 22.0 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02698.1 - 4e-08 33.4 0.4 0.042 14.1 0.0 3.8 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2963 PF11178.8 ETO02698.1 - 0.26 11.0 2.4 18 5.1 0.1 3.6 2 2 0 2 2 2 0 Protein of unknown function (DUF2963) FlaC_arch PF05377.11 ETO02699.1 - 0.0067 16.8 19.7 0.27 11.6 7.1 2.9 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) Fez1 PF06818.15 ETO02699.1 - 1.7 9.0 37.9 2.2 8.7 2.1 2.1 1 1 1 2 2 2 0 Fez1 DUF4806 PF16064.5 ETO02699.1 - 3.1 8.2 14.2 1.6 9.1 4.4 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4806) DUF948 PF06103.11 ETO02699.1 - 3.2 8.1 8.9 16 5.9 0.4 3.0 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1359 PF07097.11 ETO02699.1 - 9.2 6.6 23.5 0.11 12.7 4.7 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1359) S_layer_C PF05124.12 ETO02701.1 - 0.39 10.7 2.5 0.27 11.2 0.3 1.7 2 0 0 2 2 2 0 S-layer like family, C-terminal region Glyco_hydro_114 PF03537.13 ETO02702.1 - 0.0096 15.3 0.6 0.01 15.1 0.6 1.1 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 CdvA PF18822.1 ETO02704.1 - 0.00014 21.7 7.5 0.00014 21.7 7.5 4.0 3 2 0 3 3 3 1 CdvA-like coiled-coil domain Spc7 PF08317.11 ETO02704.1 - 0.00084 18.3 9.1 0.00084 18.3 9.1 2.4 2 0 0 2 2 2 1 Spc7 kinetochore protein MCC-bdg_PDZ PF10506.9 ETO02704.1 - 0.0023 17.9 1.4 0.013 15.5 1.4 2.4 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome Baculo_PEP_C PF04513.12 ETO02704.1 - 0.0025 17.9 3.7 0.0073 16.4 0.3 2.5 2 1 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus MscS_porin PF12795.7 ETO02704.1 - 0.0039 16.8 5.2 0.0039 16.8 5.2 2.3 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain Exonuc_VII_L PF02601.15 ETO02704.1 - 0.074 12.6 17.2 0.53 9.8 4.4 2.3 2 0 0 2 2 2 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 ETO02704.1 - 0.079 13.4 4.1 0.17 12.4 0.1 3.1 2 2 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF2197 PF09963.9 ETO02704.1 - 0.099 12.9 2.4 0.3 11.4 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) DAO_C PF16901.5 ETO02704.1 - 0.1 12.5 4.3 0.6 10.0 1.0 2.5 2 0 0 2 2 2 0 C-terminal domain of alpha-glycerophosphate oxidase DUF1939 PF09154.10 ETO02704.1 - 0.19 11.9 1.4 0.4 10.9 0.9 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF1939) DUF1664 PF07889.12 ETO02704.1 - 0.35 10.9 9.0 0.59 10.2 0.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FlxA PF14282.6 ETO02704.1 - 0.5 10.4 18.4 5.9 6.9 0.1 4.2 3 2 0 3 3 3 0 FlxA-like protein Ntox28 PF15605.6 ETO02704.1 - 0.6 10.4 4.6 0.68 10.2 0.2 3.0 2 1 0 2 2 2 0 Bacterial toxin 28 KfrA_N PF11740.8 ETO02704.1 - 0.62 10.8 5.1 14 6.4 0.8 3.1 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term WXG100 PF06013.12 ETO02704.1 - 0.84 9.9 4.4 57 4.0 0.1 3.8 4 1 0 4 4 3 0 Proteins of 100 residues with WXG COG2 PF06148.11 ETO02704.1 - 0.87 9.7 20.7 0.47 10.5 0.3 4.5 2 2 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 TolA_bind_tri PF16331.5 ETO02704.1 - 1.2 9.2 11.1 5.2 7.2 0.0 3.7 3 0 0 3 3 3 0 TolA binding protein trimerisation Snapin_Pallidin PF14712.6 ETO02704.1 - 1.3 9.5 19.4 2.7 8.5 0.2 3.9 2 1 1 3 3 3 0 Snapin/Pallidin DUF3450 PF11932.8 ETO02704.1 - 1.6 8.0 17.7 0.12 11.7 0.3 3.9 2 2 2 4 4 4 0 Protein of unknown function (DUF3450) DUF4094 PF13334.6 ETO02704.1 - 1.7 9.1 12.9 2.9 8.4 1.0 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) Laminin_II PF06009.12 ETO02704.1 - 2.3 8.2 15.8 0.44 10.5 1.4 4.0 2 2 1 4 4 4 0 Laminin Domain II DUF4407 PF14362.6 ETO02704.1 - 3.2 7.0 23.5 0.046 13.1 6.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) ApoO PF09769.9 ETO02704.1 - 9.4 6.2 15.2 3.6 7.6 0.4 4.0 2 1 1 3 3 3 0 Apolipoprotein O ubiquitin PF00240.23 ETO02706.1 - 1e-21 76.4 0.3 1.2e-20 73.0 0.0 2.8 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ETO02706.1 - 5.7e-10 38.9 0.0 2e-09 37.1 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Hint PF01079.20 ETO02706.1 - 2e-09 37.3 0.0 3.6e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Hint module Intein_splicing PF14890.6 ETO02706.1 - 6.4e-05 22.9 0.3 6.4e-05 22.9 0.3 2.2 2 0 0 2 2 2 1 Intein splicing domain Hom_end_hint PF05203.16 ETO02706.1 - 7e-05 22.9 0.1 0.00018 21.6 0.1 1.7 1 0 0 1 1 1 1 Hom_end-associated Hint Vint PF14623.6 ETO02706.1 - 0.00013 21.9 0.1 0.00026 20.8 0.1 1.5 1 0 0 1 1 1 1 Hint-domain AXH PF08517.12 ETO02706.1 - 0.00072 20.1 0.1 0.0035 17.9 0.0 2.2 2 0 0 2 2 2 1 Ataxin-1 and HBP1 module (AXH) PT-HINT PF07591.11 ETO02706.1 - 0.0032 17.7 0.5 0.014 15.7 0.3 2.0 2 0 0 2 2 2 1 Pretoxin HINT domain TBK1_ULD PF18396.1 ETO02706.1 - 0.022 14.7 0.3 0.6 10.1 0.0 3.0 3 0 0 3 3 3 0 TANK binding kinase 1 ubiquitin-like domain TPR_12 PF13424.6 ETO02707.1 - 8.8e-60 199.0 1.4 2.9e-19 69.1 0.0 4.0 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02707.1 - 7e-42 140.2 0.1 2.4e-12 46.3 0.0 4.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02707.1 - 2.9e-27 93.3 13.0 1.1e-08 34.5 0.2 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02707.1 - 3.1e-27 92.5 0.3 3.1e-08 33.1 0.0 3.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02707.1 - 2.2e-21 74.2 14.2 8.4e-07 28.7 0.4 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02707.1 - 9.6e-18 62.8 6.5 6.5e-05 22.7 0.1 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02707.1 - 1.4e-14 53.3 0.2 0.00086 19.5 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02707.1 - 3.8e-13 49.8 0.0 0.013 16.1 0.0 3.6 2 2 2 4 4 4 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02707.1 - 1.5e-10 41.1 0.3 0.024 14.4 0.0 3.1 3 0 0 3 3 3 3 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO02707.1 - 1.6e-07 31.6 0.0 1.1 10.3 0.0 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat MIT PF04212.18 ETO02707.1 - 4.9e-07 29.7 4.0 0.07 13.2 0.0 3.2 3 0 0 3 3 3 3 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO02707.1 - 1.1e-06 28.5 3.8 0.57 10.5 0.1 3.2 3 0 0 3 3 3 3 PPR repeat TPR_3 PF07720.12 ETO02707.1 - 1.4e-06 28.2 3.6 0.33 11.0 0.1 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02707.1 - 1.9e-05 24.3 18.2 1.5 8.6 0.5 6.9 4 3 3 7 7 7 2 TPR repeat TPR_6 PF13174.6 ETO02707.1 - 0.00039 20.9 0.0 8.6 7.2 0.0 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat SNAP PF14938.6 ETO02707.1 - 0.00065 19.2 0.1 0.0015 18.1 0.1 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 ETO02707.1 - 0.0016 18.9 0.0 0.21 12.1 0.0 2.9 1 1 2 4 4 3 2 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO02707.1 - 0.0032 17.0 0.2 22 4.7 0.0 4.1 4 1 1 5 5 5 0 Helix-turn-helix bacterial domain Sel1 PF08238.12 ETO02707.1 - 0.004 17.8 3.4 9.9 7.0 0.0 4.6 4 2 0 4 4 3 0 Sel1 repeat DUF3627 PF12299.8 ETO02707.1 - 0.0077 16.3 0.7 3 8.0 0.1 3.0 1 1 2 3 3 3 1 Protein of unknown function (DUF3627) OrfA PF17495.2 ETO02707.1 - 0.029 14.5 0.0 3.9 7.7 0.0 2.2 2 0 0 2 2 2 0 Vpr-like OrfA UBA_6 PF18039.1 ETO02707.1 - 0.029 14.3 0.0 72 3.4 0.0 3.9 4 0 0 4 4 4 0 UBA-like domain ANAPC3 PF12895.7 ETO02707.1 - 0.04 14.1 0.0 0.73 10.1 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2777 PF10949.8 ETO02707.1 - 0.042 13.5 0.0 18 4.9 0.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF2777) DUF5112 PF17139.4 ETO02707.1 - 0.084 12.3 0.1 44 3.4 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5112) TPR_MalT PF17874.1 ETO02707.1 - 0.11 11.9 0.0 0.12 11.8 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region Fis1_TPR_C PF14853.6 ETO02707.1 - 0.5 10.5 4.7 14 5.8 0.3 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Bombolitin PF08096.11 ETO02707.1 - 0.64 10.4 0.0 0.64 10.4 0.0 2.6 4 0 0 4 4 1 0 Bombolitin family YabA PF06156.13 ETO02708.1 - 0.0033 18.0 6.5 0.0033 18.0 6.5 2.0 1 1 1 2 2 2 1 Initiation control protein YabA DUF4686 PF15742.5 ETO02708.1 - 0.0043 16.2 11.1 0.0043 16.2 11.1 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4686) Rootletin PF15035.6 ETO02708.1 - 0.007 16.4 6.4 0.0087 16.1 6.4 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion Perilipin PF03036.16 ETO02708.1 - 0.013 14.5 2.0 0.013 14.5 2.0 1.1 1 0 0 1 1 1 0 Perilipin family ZapB PF06005.12 ETO02708.1 - 0.015 15.7 5.9 0.015 15.7 5.9 1.9 1 1 1 2 2 2 0 Cell division protein ZapB Peptidase_M17_N PF02789.17 ETO02708.1 - 0.023 14.6 0.2 0.033 14.0 0.2 1.3 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain ADIP PF11559.8 ETO02708.1 - 0.061 13.4 11.4 0.081 13.0 11.4 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding DIT1_PvcA PF05141.12 ETO02708.1 - 0.2 11.1 5.4 0.24 10.8 5.4 1.0 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein JIP_LZII PF16471.5 ETO02708.1 - 1.5 9.0 14.4 0.098 12.8 9.0 1.9 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II bZIP_1 PF00170.21 ETO02708.1 - 3 8.0 9.3 0.27 11.3 3.4 2.2 1 1 1 2 2 2 0 bZIP transcription factor UPF0242 PF06785.11 ETO02708.1 - 3.6 7.6 14.5 5.2 7.1 14.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 ETO02708.1 - 4.2 6.6 5.7 5.1 6.4 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SpoIISA_toxin PF14171.6 ETO02708.1 - 7.9 6.1 11.9 4.9 6.8 0.9 2.1 1 1 1 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system ubiquitin PF00240.23 ETO02709.1 - 1.1e-100 329.4 11.4 2.5e-33 113.6 0.4 3.0 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ETO02709.1 - 6.3e-49 163.7 11.9 2.3e-16 59.4 0.5 3.1 3 0 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO02709.1 - 5.6e-19 68.4 4.6 0.0001 22.7 0.1 4.5 3 3 0 3 3 3 3 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO02709.1 - 3.2e-13 49.4 3.9 0.0049 16.8 0.1 3.2 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO02709.1 - 1.2e-12 47.9 1.4 0.018 15.2 0.0 4.0 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO02709.1 - 4.3e-11 43.0 7.6 0.015 15.6 0.8 3.2 2 1 1 3 3 3 3 Ubiquitin-like domain DUF2407 PF10302.9 ETO02709.1 - 1.1e-10 42.0 0.3 0.091 13.3 0.0 3.2 1 1 1 3 3 3 3 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO02709.1 - 3.5e-07 30.2 11.7 4.9 7.3 0.3 6.0 4 2 2 6 6 6 1 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ETO02709.1 - 1.4e-05 25.0 0.1 1.7 8.4 0.0 3.2 3 0 0 3 3 3 2 Silencing defective 2 N-terminal ubiquitin domain DUF2870 PF11069.8 ETO02709.1 - 0.00018 21.8 1.5 21 5.6 0.0 4.6 3 3 3 6 6 6 0 Protein of unknown function (DUF2870) PI3K_rbd PF00794.18 ETO02709.1 - 0.00019 21.6 3.5 3.4 7.9 0.0 3.4 3 0 0 3 3 3 1 PI3-kinase family, ras-binding domain eRF1_1 PF03463.15 ETO02709.1 - 0.0012 18.9 0.8 7.5 6.6 0.0 3.3 3 0 0 3 3 3 0 eRF1 domain 1 RBD PF02196.15 ETO02709.1 - 0.0026 17.8 0.0 19 5.4 0.0 3.3 3 0 0 3 3 3 0 Raf-like Ras-binding domain Big_7 PF17957.1 ETO02709.1 - 0.0049 17.6 0.0 5.4 7.8 0.0 3.1 3 0 0 3 3 3 1 Bacterial Ig domain USP7_C2 PF14533.6 ETO02709.1 - 0.008 15.9 3.1 9.3 5.9 0.2 3.1 3 0 0 3 3 3 0 Ubiquitin-specific protease C-terminal DUF3861 PF12977.7 ETO02709.1 - 0.012 15.8 0.6 29 4.9 0.0 3.2 3 0 0 3 3 3 0 Domain of Unknown Function with PDB structure (DUF3861) DUF969 PF06149.12 ETO02709.1 - 0.012 15.1 0.1 20 4.5 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF969) ProRS-C_2 PF09181.10 ETO02709.1 - 0.019 15.1 2.0 27 5.0 0.1 3.2 3 0 0 3 3 3 0 Prolyl-tRNA synthetase, C-terminal DUF3379 PF11859.8 ETO02709.1 - 0.022 14.1 0.1 6.9 5.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3379) DUF5383 PF17355.2 ETO02709.1 - 0.03 14.7 5.2 24 5.3 0.1 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5383) Raf1_HTH PF18579.1 ETO02709.1 - 0.03 14.0 0.2 67 3.3 0.0 3.2 3 0 0 3 3 3 0 Rubisco accumulation factor 1 helix turn helix domain DUF3435 PF11917.8 ETO02709.1 - 0.051 12.5 0.3 24 3.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3435) Big_3_3 PF13750.6 ETO02709.1 - 0.11 12.1 0.4 8.9 5.9 0.1 2.9 1 1 1 2 2 2 0 Bacterial Ig-like domain (group 3) FlgD_ig PF13860.6 ETO02709.1 - 0.13 12.1 3.8 46 4.0 0.1 3.4 3 0 0 3 3 3 0 FlgD Ig-like domain PI3K_p85B PF02192.16 ETO02709.1 - 0.17 11.6 3.7 48 3.8 0.1 3.4 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Polysacc_deac_3 PF15421.6 ETO02709.1 - 0.19 10.2 0.8 9.6 4.6 0.1 2.9 1 1 1 2 2 2 0 Putative polysaccharide deacetylase LBP_C PF17386.2 ETO02709.1 - 0.19 11.7 1.3 65 3.5 0.1 3.2 3 0 0 3 3 3 0 Lacto-N-biose phosphorylase C-terminal domain LppX_LprAFG PF07161.13 ETO02709.1 - 0.2 11.5 2.5 6.7 6.5 0.1 2.6 2 1 1 3 3 2 0 LppX_LprAFG lipoprotein DMA PF03474.14 ETO02709.1 - 0.5 10.0 1.7 1.2e+02 2.4 0.0 3.2 3 0 0 3 3 3 0 DMRTA motif Phage_sheath_1N PF17481.2 ETO02709.1 - 0.91 10.0 3.3 1.1e+02 3.4 3.3 3.0 1 1 0 1 1 1 0 Phage tail sheath protein beta-sandwich domain Pox_A28 PF04584.14 ETO02709.1 - 1.3 9.3 3.3 26 5.0 0.3 2.9 3 0 0 3 3 3 0 Poxvirus A28 family ALMT PF11744.8 ETO02710.1 - 0.025 13.4 3.6 0.039 12.8 3.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF295 PF03478.18 ETO02710.1 - 0.22 11.1 0.9 16 5.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF295) GIT1_C PF12205.8 ETO02710.1 - 1 9.5 6.4 0.47 10.6 3.4 2.0 2 0 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term HalX PF08663.10 ETO02710.1 - 1.8 8.9 7.3 0.68 10.3 2.0 2.3 2 0 0 2 2 2 0 HalX domain Adaptin_binding PF10199.9 ETO02710.1 - 2.8 8.5 10.1 20 5.8 10.1 2.0 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 WD40 PF00400.32 ETO02713.1 - 4.8e-32 109.5 17.7 8.6e-07 29.6 0.6 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO02713.1 - 6.7e-08 31.6 4.7 0.015 14.0 0.2 4.0 2 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02713.1 - 1.5e-06 28.4 1.1 0.85 10.0 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain HARP PF07443.13 ETO02713.1 - 0.025 14.2 0.0 0.67 9.6 0.0 2.9 3 0 0 3 3 3 0 HepA-related protein (HARP) ELM2 PF01448.24 ETO02715.1 - 0.0068 17.1 0.0 0.018 15.8 0.0 1.7 1 0 0 1 1 1 1 ELM2 domain DiSB-ORF2_chro PF16506.5 ETO02715.1 - 0.049 13.6 0.0 8.2 6.5 0.0 2.4 2 0 0 2 2 2 0 Putative virion glycoprotein of insect viruses Lustrin_cystein PF14625.6 ETO02716.1 - 0.075 13.4 0.8 0.12 12.7 0.8 1.4 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain Antibiotic_NAT PF02522.14 ETO02717.1 - 0.1 12.4 0.6 0.14 11.9 0.6 1.1 1 0 0 1 1 1 0 Aminoglycoside 3-N-acetyltransferase TolA_bind_tri PF16331.5 ETO02717.1 - 0.42 10.7 10.7 4 7.6 4.5 3.1 1 1 1 2 2 2 0 TolA binding protein trimerisation Jnk-SapK_ap_N PF09744.9 ETO02717.1 - 0.61 10.3 13.9 1.1 9.5 12.8 1.7 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 ADIP PF11559.8 ETO02717.1 - 1 9.4 17.4 0.044 13.9 9.0 1.9 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding FAM76 PF16046.5 ETO02717.1 - 2.8 7.2 13.2 3.1 7.1 13.2 1.0 1 0 0 1 1 1 0 FAM76 protein ZapB PF06005.12 ETO02717.1 - 4.5 7.8 17.0 0.064 13.7 3.0 2.2 1 1 1 2 2 2 0 Cell division protein ZapB VPS13 PF16908.5 ETO02719.1 - 3.6e-13 49.9 0.0 4.8e-13 49.5 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal DUF809 PF05663.11 ETO02719.1 - 0.0027 17.9 0.4 0.0038 17.4 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF809) FAM176 PF14851.6 ETO02719.1 - 0.006 16.2 1.1 0.0087 15.7 1.1 1.4 1 0 0 1 1 1 1 FAM176 family Nop14 PF04147.12 ETO02719.1 - 0.0067 14.7 12.6 0.0085 14.4 12.6 1.1 1 0 0 1 1 1 1 Nop14-like family CSRNP_N PF16019.5 ETO02719.1 - 0.014 15.4 1.4 0.018 15.0 1.4 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus TRAP_alpha PF03896.16 ETO02719.1 - 0.12 11.6 6.8 0.18 11.0 6.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TFIIF_alpha PF05793.12 ETO02719.1 - 0.29 9.7 22.2 0.36 9.4 22.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CobT PF06213.12 ETO02719.1 - 1.5 8.1 16.5 2 7.7 16.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2457 PF10446.9 ETO02719.1 - 1.6 7.8 15.7 2 7.5 15.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4637 PF15470.6 ETO02719.1 - 1.8 8.3 14.5 2.6 7.8 14.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 ETO02719.1 - 2.4 6.4 14.5 2.9 6.1 14.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO02719.1 - 5.9 4.9 18.5 7.7 4.5 18.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi Afi1 PF07792.12 ETO02719.1 - 7.5 7.0 14.6 12 6.4 14.6 1.5 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MAD PF05557.13 ETO02720.1 - 0.0063 14.9 26.9 0.007 14.8 26.9 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein Csm1_N PF18504.1 ETO02720.1 - 0.038 14.3 4.7 0.038 14.3 4.7 3.2 1 1 2 3 3 3 0 Csm1 N-terminal domain Phage_GPO PF05929.11 ETO02720.1 - 0.53 9.9 14.9 0.63 9.6 14.9 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase LMBR1 PF04791.16 ETO02720.1 - 0.55 9.1 13.9 0.62 8.9 13.9 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Macoilin PF09726.9 ETO02720.1 - 1.4 7.3 22.9 1.7 7.1 22.9 1.0 1 0 0 1 1 1 0 Macoilin family Mucin15 PF15672.5 ETO02720.1 - 1.6 8.1 8.5 2 7.8 8.5 1.2 1 0 0 1 1 1 0 Cell-membrane associated Mucin15 Seryl_tRNA_N PF02403.22 ETO02720.1 - 2.6 8.3 28.9 0.53 10.5 20.8 2.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Golgin_A5 PF09787.9 ETO02720.1 - 6 6.2 24.6 13 5.1 24.6 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 5 Menin PF05053.13 ETO02722.1 - 0.75 8.1 12.3 0.83 7.9 12.3 1.1 1 0 0 1 1 1 0 Menin TFIIF_alpha PF05793.12 ETO02722.1 - 5.3 5.5 29.2 6 5.3 29.2 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FOXP-CC PF16159.5 ETO02726.1 - 0.096 13.3 2.6 1 10.0 0.3 3.5 2 1 0 2 2 2 0 FOXP coiled-coil domain 7tm_1 PF00001.21 ETO02727.1 - 0.0039 16.6 0.0 0.0047 16.3 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) MAP17 PF15807.5 ETO02727.1 - 0.0087 16.3 2.0 0.01 16.0 2.0 1.1 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 PEX11 PF05648.14 ETO02727.1 - 0.099 12.1 1.0 0.11 11.9 1.0 1.0 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) YMF19 PF02326.15 ETO02727.1 - 0.38 11.5 4.9 0.54 11.1 4.9 1.3 1 1 0 1 1 1 0 Plant ATP synthase F0 zf-CCHC_4 PF14392.6 ETO02728.1 - 0.044 13.5 10.0 1.3 8.8 1.3 2.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 ETO02728.1 - 0.48 10.6 10.7 0.75 10.0 1.4 2.6 2 0 0 2 2 2 0 Zinc knuckle FAM176 PF14851.6 ETO02730.1 - 8.3 6.1 8.4 10 5.8 8.4 1.3 1 0 0 1 1 1 0 FAM176 family DDOST_48kD PF03345.14 ETO02732.1 - 0.026 13.4 0.6 0.03 13.1 0.6 1.0 1 0 0 1 1 1 0 Oligosaccharyltransferase 48 kDa subunit beta DUF5339 PF17274.2 ETO02732.1 - 0.11 13.4 2.8 0.15 12.9 2.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5339) PLA2_B PF01735.18 ETO02733.1 - 0.068 11.6 0.1 0.076 11.4 0.1 1.1 1 0 0 1 1 1 0 Lysophospholipase catalytic domain TF_AP-2 PF03299.14 ETO02734.1 - 0.038 14.0 4.3 0.042 13.8 4.3 1.1 1 0 0 1 1 1 0 Transcription factor AP-2 Tho2 PF11262.8 ETO02734.1 - 0.092 11.9 11.9 0.12 11.6 11.9 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 LRS4 PF10422.9 ETO02734.1 - 0.37 10.3 15.3 0.42 10.1 15.3 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 FtsX_ECD PF18075.1 ETO02734.1 - 0.4 11.3 9.9 4.3 8.0 3.1 2.3 1 1 1 2 2 2 0 FtsX extracellular domain Cbl_N2 PF02761.14 ETO02734.1 - 3.2 8.5 6.9 8.3 7.2 1.4 2.5 1 1 2 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain PTPlike_phytase PF14566.6 ETO02734.1 - 3.6 7.7 7.1 12 6.0 7.1 1.8 1 1 0 1 1 1 0 Inositol hexakisphosphate WD40 PF00400.32 ETO02735.1 - 1.3e-89 291.7 47.6 1.5e-10 41.4 0.5 11.5 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02735.1 - 1.3e-24 86.3 10.8 0.093 13.0 0.0 10.1 1 1 9 10 10 10 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO02735.1 - 3.3e-13 49.3 1.0 0.61 9.0 0.2 8.7 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO02735.1 - 4.6e-11 42.9 0.0 8.1e-11 42.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO02735.1 - 0.00022 21.8 0.5 0.002 18.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain TolB_N PF04052.13 ETO02735.1 - 0.00029 21.0 1.1 1.7 8.8 0.0 5.6 7 1 1 8 8 8 1 TolB amino-terminal domain AAA_22 PF13401.6 ETO02735.1 - 0.0047 17.2 0.0 0.019 15.3 0.0 2.0 2 0 0 2 2 2 1 AAA domain ATP_bind_2 PF03668.15 ETO02735.1 - 0.019 14.3 0.0 0.04 13.2 0.0 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family PD40 PF07676.12 ETO02735.1 - 0.02 14.8 8.6 41 4.3 0.0 6.5 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat RNA_helicase PF00910.22 ETO02735.1 - 0.023 15.1 1.2 0.49 10.8 0.0 3.5 3 1 0 3 3 3 0 RNA helicase RsgA_GTPase PF03193.16 ETO02735.1 - 0.05 13.5 1.5 0.2 11.6 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase Ndc1_Nup PF09531.10 ETO02736.1 - 7.1 5.2 12.2 9.3 4.8 12.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RPEL PF02755.15 ETO02737.1 - 6.1e-08 32.1 11.0 0.0023 17.6 0.2 4.0 3 1 1 4 4 4 3 RPEL repeat SseB_C PF14581.6 ETO02737.1 - 0.0086 16.2 0.1 0.016 15.3 0.1 1.4 1 1 0 1 1 1 1 SseB protein C-terminal domain MHB PF16525.5 ETO02737.1 - 0.058 13.7 0.3 0.8 10.0 0.0 2.5 1 1 2 3 3 3 0 Haemophore, haem-binding WD40 PF00400.32 ETO02738.1 - 0.00093 20.0 6.3 0.0013 19.5 0.9 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ATP_bind_1 PF03029.17 ETO02738.1 - 0.11 12.3 0.2 0.12 12.1 0.2 1.0 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein zf-C3HC4_3 PF13920.6 ETO02739.1 - 0.0081 16.0 4.0 0.15 12.0 4.0 2.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO02739.1 - 0.022 15.1 5.5 0.022 15.1 5.5 2.9 2 1 1 3 3 3 0 Ring finger domain zf-rbx1 PF12678.7 ETO02739.1 - 0.28 11.5 9.4 0.11 12.8 5.2 2.5 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ETO02739.1 - 2.4 8.4 9.7 29 4.9 0.1 3.4 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING Pico_P2B PF01552.17 ETO02740.1 - 0.069 13.3 0.3 0.12 12.5 0.3 1.5 1 0 0 1 1 1 0 Picornavirus 2B protein RsgA_GTPase PF03193.16 ETO02742.1 - 2.4e-06 27.5 0.5 5.7e-05 23.1 0.5 2.3 1 1 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO02742.1 - 7.1e-06 26.1 1.6 8.3e-05 22.6 0.5 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO02742.1 - 0.00013 22.5 0.3 0.00018 22.0 0.3 1.3 1 1 0 1 1 1 1 ABC transporter Dynamin_N PF00350.23 ETO02742.1 - 0.00019 21.5 1.2 0.12 12.4 0.0 2.5 1 1 1 2 2 2 2 Dynamin family AAA_29 PF13555.6 ETO02742.1 - 0.002 17.8 0.0 0.0038 16.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO02742.1 - 0.0036 17.8 0.1 0.0061 17.1 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO02742.1 - 0.0095 16.2 0.0 0.015 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_PrkA PF08298.11 ETO02742.1 - 0.011 14.7 0.0 0.015 14.3 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain Septin PF00735.18 ETO02742.1 - 0.014 14.7 0.1 0.023 14.0 0.1 1.3 1 0 0 1 1 1 0 Septin AAA_28 PF13521.6 ETO02742.1 - 0.018 15.3 0.2 0.038 14.2 0.2 1.7 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ETO02742.1 - 0.019 14.0 0.1 0.028 13.5 0.1 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein RuvB_N PF05496.12 ETO02742.1 - 0.021 14.6 0.1 0.92 9.2 0.1 2.1 1 1 1 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 ETO02742.1 - 0.025 13.7 0.1 0.055 12.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_19 PF13245.6 ETO02742.1 - 0.026 14.8 0.0 0.029 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF5388 PF17363.2 ETO02742.1 - 0.033 14.4 0.1 0.12 12.6 0.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5388) TsaE PF02367.17 ETO02742.1 - 0.039 14.0 0.1 0.071 13.1 0.1 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRP54 PF00448.22 ETO02742.1 - 0.049 13.3 0.3 0.12 12.0 0.2 1.9 1 1 0 1 1 1 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 ETO02742.1 - 0.053 13.3 0.0 0.13 12.0 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PhoH PF02562.16 ETO02742.1 - 0.054 12.9 0.1 0.1 12.0 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein Zeta_toxin PF06414.12 ETO02742.1 - 0.059 12.6 0.1 0.1 11.9 0.1 1.4 1 0 0 1 1 1 0 Zeta toxin MCM PF00493.23 ETO02742.1 - 0.066 12.3 0.0 0.12 11.5 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain AAA_33 PF13671.6 ETO02742.1 - 0.074 13.2 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain DnaB_2 PF07261.11 ETO02742.1 - 0.097 12.4 0.3 1.6 8.6 0.1 2.4 2 0 0 2 2 2 0 Replication initiation and membrane attachment Ploopntkinase3 PF18751.1 ETO02742.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_7 PF12775.7 ETO02742.1 - 0.13 11.8 0.1 0.24 10.9 0.1 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region STI1 PF17830.1 ETO02743.1 - 0.0015 18.4 0.2 0.26 11.3 0.0 2.6 2 1 0 2 2 2 2 STI1 domain NACHT PF05729.12 ETO02743.1 - 0.02 14.8 0.0 0.028 14.4 0.0 1.2 1 0 0 1 1 1 0 NACHT domain Peptidase_C14 PF00656.22 ETO02744.1 - 0.00059 19.9 0.2 0.0007 19.6 0.2 1.1 1 0 0 1 1 1 1 Caspase domain TPR_12 PF13424.6 ETO02745.1 - 7e-65 215.3 9.9 4.1e-22 78.3 0.3 3.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02745.1 - 2e-36 122.8 0.1 3e-10 39.6 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02745.1 - 4.4e-30 102.2 17.8 4.4e-11 42.1 1.9 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02745.1 - 3.4e-29 98.7 1.2 2.1e-07 30.5 0.0 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02745.1 - 2.9e-20 70.7 17.6 3.1e-08 33.2 0.9 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02745.1 - 6.8e-18 63.3 10.7 5.1e-07 29.3 0.5 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02745.1 - 7.3e-12 44.8 8.7 0.0043 17.3 0.1 5.0 3 1 0 5 5 5 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02745.1 - 1.6e-09 38.3 0.0 0.019 15.6 0.0 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02745.1 - 1.3e-08 35.0 0.0 0.42 11.6 0.0 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat MIT PF04212.18 ETO02745.1 - 1.1e-07 31.8 9.1 0.013 15.6 0.2 3.4 2 1 1 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO02745.1 - 3.4e-07 30.1 5.0 0.1 12.6 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02745.1 - 1.9e-06 27.7 9.5 0.07 12.9 0.2 3.4 2 1 2 4 4 4 3 Domain of unknown function (DUF5113) PPR PF01535.20 ETO02745.1 - 4.7e-05 23.3 3.5 0.12 12.7 0.2 3.5 3 0 0 3 3 3 1 PPR repeat HTH_Bact PF18768.1 ETO02745.1 - 7.2e-05 22.3 2.1 1.1 8.9 0.1 4.3 4 0 0 4 4 4 1 Helix-turn-helix bacterial domain TPR_6 PF13174.6 ETO02745.1 - 0.00014 22.3 0.2 1 10.1 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO02745.1 - 0.0004 20.4 5.8 0.46 10.6 0.3 4.1 4 0 0 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ETO02745.1 - 0.00049 20.3 2.8 0.02 15.1 0.3 2.5 1 1 2 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETO02745.1 - 0.00057 19.3 0.0 0.00068 19.1 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region DUF4810 PF16068.5 ETO02745.1 - 0.0006 20.3 0.5 0.25 11.9 0.1 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4810) TPR_11 PF13414.6 ETO02745.1 - 0.0044 16.7 22.5 1 9.1 0.9 6.5 3 2 4 7 7 7 2 TPR repeat TPR_19 PF14559.6 ETO02745.1 - 0.015 15.8 0.1 0.48 11.0 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Pep3_Vps18 PF05131.14 ETO02745.1 - 0.015 15.1 0.5 9.1 6.1 0.0 3.2 2 1 1 3 3 3 0 Pep3/Vps18/deep orange family DUF627 PF04781.12 ETO02745.1 - 0.043 13.8 1.3 0.76 9.8 0.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF627) KH_4 PF13083.6 ETO02745.1 - 0.058 13.3 0.0 0.18 11.7 0.0 1.8 1 1 0 1 1 1 0 KH domain bMG1 PF17970.1 ETO02745.1 - 0.12 12.5 0.0 1.4 9.0 0.0 2.4 1 1 2 3 3 3 0 Bacterial Alpha-2-macroglobulin MG1 domain SLT PF01464.20 ETO02745.1 - 0.72 9.5 4.0 5.6 6.6 0.2 2.9 1 1 2 3 3 3 0 Transglycosylase SLT domain IL3 PF02059.15 ETO02746.1 - 0.036 14.1 0.2 0.046 13.8 0.2 1.1 1 0 0 1 1 1 0 Interleukin-3 Xpo1 PF08389.12 ETO02746.1 - 0.11 12.6 0.9 0.19 11.8 0.9 1.5 1 1 0 1 1 1 0 Exportin 1-like protein KinB_sensor PF16767.5 ETO02748.1 - 1.3 9.5 9.6 3.3 8.2 0.1 3.1 3 1 0 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB Biliv-reduc_cat PF09166.10 ETO02749.1 - 0.15 12.4 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Biliverdin reductase, catalytic CSD PF00313.22 ETO02750.1 - 0.00025 20.8 0.1 0.016 15.0 0.0 2.8 3 1 0 3 3 3 2 'Cold-shock' DNA-binding domain TBCA PF02970.16 ETO02751.1 - 3.5e-20 72.1 9.1 4.7e-20 71.7 9.1 1.2 1 0 0 1 1 1 1 Tubulin binding cofactor A Spc7 PF08317.11 ETO02751.1 - 0.0073 15.2 6.1 0.0073 15.2 6.1 1.9 1 1 1 2 2 2 1 Spc7 kinetochore protein TMPIT PF07851.13 ETO02751.1 - 0.05 12.8 4.1 0.056 12.7 4.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein YlqD PF11068.8 ETO02751.1 - 0.13 12.7 7.4 0.19 12.1 7.4 1.3 1 0 0 1 1 1 0 YlqD protein FlxA PF14282.6 ETO02751.1 - 0.15 12.0 8.8 0.28 11.2 8.8 1.5 1 0 0 1 1 1 0 FlxA-like protein AAA_13 PF13166.6 ETO02751.1 - 0.15 10.7 6.5 0.16 10.6 6.5 1.0 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.6 ETO02751.1 - 0.18 10.8 4.2 0.2 10.6 4.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF2570 PF10828.8 ETO02751.1 - 0.27 11.1 7.4 0.12 12.2 4.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2570) DUF2203 PF09969.9 ETO02751.1 - 0.36 11.6 5.4 0.45 11.2 4.9 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) FapA PF03961.13 ETO02751.1 - 0.98 7.9 7.8 1.1 7.8 7.8 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 ETO02751.1 - 6.2 7.5 8.9 7.1 7.3 7.8 1.6 1 1 1 2 2 2 0 Initiation control protein YabA DnaJ PF00226.31 ETO02753.1 - 0.00016 21.8 1.1 0.00023 21.2 0.0 1.8 2 0 0 2 2 2 1 DnaJ domain WD40 PF00400.32 ETO02754.1 - 2.1e-54 180.3 16.5 1.3e-11 44.8 0.1 6.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02754.1 - 2.8e-20 72.4 0.0 0.0011 19.2 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO02754.1 - 9.1e-13 48.2 0.0 1.4e-06 27.9 0.0 3.4 1 1 3 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO02754.1 - 1.4e-09 37.3 0.1 0.26 10.2 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO02754.1 - 2.8e-07 30.3 0.6 7.5 6.6 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO02754.1 - 9.3e-07 28.5 1.6 0.076 12.3 0.1 3.5 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO02754.1 - 1.3e-06 27.4 0.3 1.6 7.3 0.0 4.7 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO02754.1 - 2.6e-06 26.2 0.7 0.044 12.3 0.1 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain Frtz PF11768.8 ETO02754.1 - 2.8e-05 22.6 0.0 0.082 11.2 0.0 3.2 1 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz NYD-SP28_assoc PF14775.6 ETO02754.1 - 0.00012 22.1 0.3 19 5.5 0.0 4.6 5 0 0 5 5 5 0 Sperm tail C-terminal domain BBS2_Mid PF14783.6 ETO02754.1 - 0.00017 21.6 0.4 4.3 7.4 0.0 4.5 1 1 3 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DUF5570 PF17731.1 ETO02754.1 - 0.0012 18.9 2.4 7.6 6.7 0.0 3.9 1 1 3 4 4 4 1 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO02754.1 - 0.0019 17.9 5.3 30 4.4 0.1 4.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF3475 PF11961.8 ETO02754.1 - 0.0042 17.1 1.7 25 5.0 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) TolB_N PF04052.13 ETO02754.1 - 0.0052 16.9 0.0 26 5.1 0.0 4.3 5 0 0 5 5 5 0 TolB amino-terminal domain VID27 PF08553.10 ETO02754.1 - 0.018 14.2 0.0 1.1 8.2 0.0 2.4 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain DPPIV_N PF00930.21 ETO02754.1 - 0.02 13.7 0.1 25 3.5 0.0 3.5 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Invas_SpaK PF03519.14 ETO02754.1 - 0.02 14.9 0.2 1.9 8.6 0.0 2.7 2 1 1 3 3 3 0 Invasion protein B family Nucleoporin_N PF08801.11 ETO02754.1 - 0.027 13.2 2.1 0.083 11.6 0.8 2.3 1 1 1 2 2 2 0 Nup133 N terminal like Read-through PF16814.5 ETO02754.1 - 0.039 13.7 0.3 5.2 6.8 0.0 2.8 1 1 3 4 4 4 0 Read-through domain SLH PF00395.20 ETO02754.1 - 0.18 11.8 0.0 68 3.6 0.0 3.5 3 0 0 3 3 3 0 S-layer homology domain CH PF00307.31 ETO02755.1 - 4.3e-24 84.8 0.1 6.5e-13 48.8 0.0 3.5 3 0 0 3 3 3 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO02755.1 - 0.053 13.4 0.0 0.22 11.4 0.0 2.0 1 0 0 1 1 1 0 CAMSAP CH domain Chordopox_G3 PF06129.12 ETO02756.1 - 0.035 14.8 2.6 0.035 14.8 2.6 2.0 2 1 0 2 2 2 0 Chordopoxvirus G3 protein Ras PF00071.22 ETO02758.1 - 0.0012 18.5 0.1 0.0032 17.1 0.1 1.7 1 0 0 1 1 1 1 Ras family Intein_splicing PF14890.6 ETO02759.1 - 0.041 13.8 0.0 7.8 6.5 1.2 3.5 3 2 0 3 3 3 0 Intein splicing domain RE_CfrBI PF09516.10 ETO02761.1 - 0.014 14.9 11.6 0.026 13.9 11.6 1.5 1 1 0 1 1 1 0 CfrBI restriction endonuclease APG6_N PF17675.1 ETO02761.1 - 0.079 13.5 15.4 0.053 14.1 2.2 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region CorA PF01544.18 ETO02761.1 - 0.1 11.9 3.3 0.066 12.5 1.5 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein A_deaminase_N PF08451.11 ETO02761.1 - 0.29 11.4 6.3 0.72 10.2 0.5 2.3 2 0 0 2 2 2 0 Adenosine/AMP deaminase N-terminal BSMAP PF12280.8 ETO02762.1 - 0.04 14.1 0.4 0.04 14.1 0.4 1.1 1 0 0 1 1 1 0 Brain specific membrane anchored protein TACC_C PF05010.14 ETO02763.1 - 0.0009 19.1 23.5 0.0009 19.1 23.5 2.1 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal NPV_P10 PF05531.12 ETO02763.1 - 0.017 15.6 3.0 0.017 15.6 3.0 3.3 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein PilJ PF13675.6 ETO02763.1 - 0.15 12.1 10.0 0.13 12.3 4.1 2.3 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term DUF3866 PF12982.7 ETO02763.1 - 1.1 8.3 4.1 1.2 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3866) UPF0242 PF06785.11 ETO02763.1 - 2.6 8.1 51.2 0.24 11.5 18.9 3.0 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus OrfB_IS605 PF01385.19 ETO02764.1 - 0.036 14.3 0.1 0.054 13.7 0.1 1.3 1 0 0 1 1 1 0 Probable transposase DUF3944 PF13099.6 ETO02764.1 - 0.044 13.7 0.2 0.15 12.0 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) ORF6N PF10543.9 ETO02764.1 - 0.087 13.0 0.2 0.93 9.7 0.0 2.1 2 0 0 2 2 2 0 ORF6N domain U-box PF04564.15 ETO02765.1 - 2.9e-12 46.6 0.3 1e-11 44.8 0.0 2.1 2 1 0 2 2 2 1 U-box domain DNApol_Exo PF18136.1 ETO02765.1 - 0.01 15.0 0.0 0.36 9.9 0.0 2.2 2 0 0 2 2 2 0 DNA mitochondrial polymerase exonuclease domain SAM_1 PF00536.30 ETO02765.1 - 0.02 15.3 0.2 0.043 14.3 0.2 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) NFRKB_winged PF14465.6 ETO02765.1 - 0.031 14.4 2.2 0.061 13.5 2.2 1.5 1 1 0 1 1 1 0 NFRKB Winged Helix-like RhoGEF PF00621.20 ETO02768.1 - 8e-14 52.3 25.7 1.5e-10 41.6 8.1 3.5 2 1 1 3 3 3 2 RhoGEF domain FYVE PF01363.21 ETO02769.1 - 2.3e-08 34.0 2.8 4.6e-08 33.1 2.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 ETO02769.1 - 0.044 14.3 0.2 0.17 12.4 0.2 2.2 1 1 0 1 1 1 0 PH domain TEX19 PF15553.6 ETO02770.1 - 0.35 10.8 3.9 0.39 10.7 3.9 1.0 1 0 0 1 1 1 0 Testis-expressed protein 19 UPF0560 PF10577.9 ETO02770.1 - 0.48 8.9 9.7 0.57 8.6 9.7 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RR_TM4-6 PF06459.12 ETO02770.1 - 0.5 10.1 16.1 0.57 10.0 16.1 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paf1 PF03985.13 ETO02770.1 - 0.52 9.2 19.5 0.59 9.1 19.5 1.0 1 0 0 1 1 1 0 Paf1 Presenilin PF01080.17 ETO02770.1 - 0.55 8.9 10.8 0.6 8.8 10.8 1.0 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 ETO02770.1 - 0.56 10.7 9.0 0.64 10.5 9.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 ETO02770.1 - 0.57 9.3 6.2 0.6 9.3 6.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Rgp1 PF08737.10 ETO02770.1 - 0.59 9.2 7.9 0.68 9.0 7.9 1.1 1 0 0 1 1 1 0 Rgp1 DDHD PF02862.17 ETO02770.1 - 1 9.5 6.8 1.1 9.3 6.8 1.0 1 0 0 1 1 1 0 DDHD domain RP-C_C PF11800.8 ETO02770.1 - 1 9.4 9.6 1.2 9.2 9.6 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region PPL5 PF18168.1 ETO02770.1 - 1.1 8.4 7.7 1.2 8.4 7.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CSG2 PF16965.5 ETO02770.1 - 1.3 7.9 2.9 1.3 7.9 2.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator CobT PF06213.12 ETO02770.1 - 1.4 8.3 17.2 1.6 8.1 17.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RasGAP PF00616.19 ETO02770.1 - 1.4 8.5 11.7 1.7 8.3 11.7 1.0 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase F-protein PF00469.20 ETO02770.1 - 1.5 8.3 9.9 1.7 8.2 9.9 1.0 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Spore_coat_CotO PF14153.6 ETO02770.1 - 1.6 8.6 17.5 1.9 8.4 17.5 1.0 1 0 0 1 1 1 0 Spore coat protein CotO SID-1_RNA_chan PF13965.6 ETO02770.1 - 1.6 7.0 3.9 1.7 6.9 3.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PTPRCAP PF15713.5 ETO02770.1 - 3.2 8.0 17.6 3.8 7.8 17.6 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Vfa1 PF08432.10 ETO02770.1 - 3.6 7.9 18.8 4.3 7.6 18.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO02770.1 - 3.6 7.3 8.6 4.5 7.0 8.6 1.3 1 0 0 1 1 1 0 Connexin TFB6 PF17110.5 ETO02770.1 - 4.5 7.0 8.1 6.1 6.6 8.1 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Hid1 PF12722.7 ETO02770.1 - 4.9 5.2 8.8 5.3 5.0 8.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Trypan_PARP PF05887.11 ETO02770.1 - 6.6 6.7 10.8 8 6.4 10.8 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Sec62 PF03839.16 ETO02770.1 - 6.8 6.1 12.9 8.1 5.9 12.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SpoIIP PF07454.11 ETO02770.1 - 7 6.0 15.8 8.4 5.8 15.8 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Neur_chan_memb PF02932.16 ETO02770.1 - 7.2 6.6 6.9 8.5 6.4 6.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region V_ATPase_I PF01496.19 ETO02770.1 - 7.5 4.3 12.4 8.2 4.2 12.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 ETO02770.1 - 7.9 5.4 6.7 8.6 5.3 6.7 1.1 1 0 0 1 1 1 0 CLN3 protein HSP90 PF00183.18 ETO02771.1 - 1.7e-59 202.1 23.1 1.4e-40 139.8 10.6 4.0 2 1 1 3 3 3 3 Hsp90 protein ABC_tran PF00005.27 ETO02772.1 - 0.0013 19.3 4.5 0.0024 18.4 0.1 2.2 2 1 0 2 2 2 1 ABC transporter T2SSE PF00437.20 ETO02772.1 - 0.0023 17.0 0.2 0.0032 16.6 0.2 1.2 1 0 0 1 1 1 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ETO02772.1 - 0.0027 17.6 0.2 0.0057 16.6 0.2 1.6 1 0 0 1 1 1 1 RsgA GTPase PhoH PF02562.16 ETO02772.1 - 0.0054 16.2 0.2 0.022 14.2 0.1 1.9 2 0 0 2 2 2 1 PhoH-like protein DUF815 PF05673.13 ETO02772.1 - 0.0086 15.3 0.1 0.013 14.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_29 PF13555.6 ETO02772.1 - 0.012 15.3 0.1 0.029 14.1 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 ETO02772.1 - 0.025 14.9 0.1 0.053 13.9 0.1 1.5 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO02772.1 - 0.026 14.2 0.1 0.04 13.6 0.1 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 ETO02772.1 - 0.032 13.8 1.3 0.036 13.6 0.1 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 ETO02772.1 - 0.033 13.9 0.3 0.14 11.9 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ETO02772.1 - 0.048 14.1 2.0 0.57 10.6 0.0 2.9 2 1 0 2 2 2 0 RNA helicase FtsK_SpoIIIE PF01580.18 ETO02772.1 - 0.081 12.3 0.2 0.13 11.6 0.2 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_28 PF13521.6 ETO02772.1 - 0.15 12.3 1.1 0.17 12.1 0.2 1.6 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 ETO02772.1 - 0.2 11.1 3.4 0.45 10.0 0.2 2.8 3 1 0 3 3 3 0 ADP-ribosylation factor family AAA_23 PF13476.6 ETO02772.1 - 1.3 9.5 10.8 0.18 12.3 0.6 2.3 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 ETO02773.1 - 2.9e-30 103.8 12.2 1.1e-09 38.7 0.1 4.5 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02773.1 - 5.4e-15 55.5 0.2 0.00045 20.5 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02773.1 - 1.8e-06 26.9 0.3 0.014 14.1 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO02773.1 - 2.4e-06 27.1 0.6 0.0017 17.7 0.1 2.1 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETO02773.1 - 3.2e-06 26.3 0.2 0.15 11.0 0.0 3.3 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO02773.1 - 5.7e-05 23.1 0.0 0.08 12.8 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A DUF5474 PF17568.2 ETO02773.1 - 0.00031 20.8 0.1 1.1 9.3 0.0 3.1 2 1 1 3 3 3 1 Family of unknown function (DUF5474) Cytochrom_D1 PF02239.16 ETO02773.1 - 0.00051 18.7 0.0 0.012 14.2 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain SGL PF08450.12 ETO02773.1 - 0.058 13.0 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region DUF1854 PF08909.11 ETO02773.1 - 0.11 12.4 0.2 2.8 7.8 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1854) Prot_ATP_ID_OB PF16450.5 ETO02773.1 - 0.11 12.4 0.0 10 6.2 0.0 2.4 2 0 0 2 2 2 0 Proteasomal ATPase OB C-terminal domain Str_synth PF03088.16 ETO02773.1 - 0.13 12.4 0.1 0.89 9.7 0.0 2.4 3 1 0 3 3 3 0 Strictosidine synthase PD40 PF07676.12 ETO02773.1 - 0.37 10.8 2.9 28 4.8 0.1 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO02773.1 - 5 6.9 8.1 5.3 6.8 0.0 3.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature SLATT_5 PF18160.1 ETO02776.1 - 0.067 12.5 0.3 0.12 11.7 0.3 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DASH_Spc19 PF08287.11 ETO02777.1 - 0.0021 18.0 2.6 0.0024 17.8 2.6 1.0 1 0 0 1 1 1 1 Spc19 Golgin_A5 PF09787.9 ETO02777.1 - 0.0071 15.9 3.6 0.0087 15.6 3.6 1.0 1 0 0 1 1 1 1 Golgin subfamily A member 5 FAM76 PF16046.5 ETO02777.1 - 0.0077 15.6 3.6 0.0085 15.5 3.6 1.0 1 0 0 1 1 1 1 FAM76 protein DUF3740 PF12548.8 ETO02777.1 - 0.083 13.3 3.3 0.12 12.8 2.8 1.4 1 1 0 1 1 1 0 Sulfatase protein DUF4140 PF13600.6 ETO02777.1 - 0.12 12.8 3.0 0.6 10.6 3.0 1.8 1 1 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) H-kinase_dim PF02895.14 ETO02777.1 - 0.27 11.6 5.6 0.63 10.5 5.6 1.6 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain DUF5320 PF17253.2 ETO02777.1 - 0.43 11.7 3.8 0.53 11.4 1.8 1.8 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Anoctamin PF04547.12 ETO02780.1 - 5.6e-74 249.6 0.4 7.3e-74 249.2 0.4 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel SAM_1 PF00536.30 ETO02780.1 - 0.00014 22.3 0.0 0.00028 21.3 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO02780.1 - 0.00051 20.1 0.0 0.0011 19.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO02780.1 - 0.0029 17.5 0.0 0.99 9.4 0.1 2.5 2 0 0 2 2 2 2 Sterile alpha motif (SAM)/Pointed domain ABC2_membrane_3 PF12698.7 ETO02780.1 - 1 8.4 4.2 3.2 6.8 0.0 2.5 2 1 1 3 3 3 0 ABC-2 family transporter protein PBP1_TM PF14812.6 ETO02780.1 - 1.1 9.7 7.8 2.8 8.4 7.8 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal YscO PF07321.12 ETO02782.1 - 0.014 15.4 5.1 0.014 15.4 5.1 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO DUF1515 PF07439.11 ETO02782.1 - 0.05 13.6 5.4 0.29 11.2 1.4 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) ZapB PF06005.12 ETO02782.1 - 0.088 13.3 0.1 0.088 13.3 0.1 4.2 4 0 0 4 4 4 0 Cell division protein ZapB CysG_dimeriser PF10414.9 ETO02782.1 - 0.1 12.3 0.0 0.31 10.8 0.0 1.8 1 0 0 1 1 1 0 Sirohaem synthase dimerisation region YabA PF06156.13 ETO02782.1 - 0.19 12.4 19.2 2.7 8.7 5.9 4.1 3 2 1 4 4 4 0 Initiation control protein YabA DUF2203 PF09969.9 ETO02782.1 - 0.58 10.9 12.3 18 6.0 3.2 4.0 2 1 2 4 4 4 0 Uncharacterized conserved protein (DUF2203) BLOC1_2 PF10046.9 ETO02782.1 - 0.72 10.2 11.4 3.3 8.1 0.4 3.8 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF349 PF03993.12 ETO02782.1 - 0.73 10.2 20.0 1 9.7 5.0 4.7 3 1 1 4 4 4 0 Domain of Unknown Function (DUF349) Spc24 PF08286.11 ETO02782.1 - 1.1 9.5 14.3 9.9 6.5 3.9 3.8 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 Death PF00531.22 ETO02782.1 - 1.4 9.1 9.6 2 8.6 0.4 3.8 4 0 0 4 4 4 0 Death domain CRIC_ras_sig PF10534.9 ETO02782.1 - 2.4 8.4 6.1 2.5 8.4 0.4 3.6 4 1 1 5 5 5 0 Connector enhancer of kinase suppressor of ras TPR_12 PF13424.6 ETO02783.1 - 2e-21 76.1 5.7 3.7e-17 62.4 0.2 2.4 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02783.1 - 4.9e-21 73.6 22.9 1.7e-08 34.0 1.3 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02783.1 - 1.3e-20 72.6 6.4 8.9e-08 31.8 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02783.1 - 2.7e-19 67.6 16.0 2e-07 30.6 0.5 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02783.1 - 8e-14 50.6 4.7 3.6e-05 23.5 0.1 3.5 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02783.1 - 7.1e-12 44.6 19.5 2.3e-06 27.4 1.1 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO02783.1 - 2.4e-09 37.2 0.2 0.0055 17.3 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02783.1 - 5.9e-09 35.5 25.7 0.0017 18.0 9.3 4.7 3 2 2 5 5 5 4 TPR repeat TPR_16 PF13432.6 ETO02783.1 - 2.8e-07 31.1 0.2 0.0003 21.4 0.2 3.1 2 2 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02783.1 - 3.1e-06 27.5 0.0 0.11 13.4 0.0 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02783.1 - 9e-06 25.7 18.1 0.053 13.9 2.0 4.2 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO02783.1 - 1.8e-05 24.6 1.1 1.8e-05 24.6 1.1 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_5 PF12688.7 ETO02783.1 - 5.3e-05 23.5 0.4 0.28 11.4 0.0 3.0 2 1 0 3 3 3 2 Tetratrico peptide repeat ANAPC3 PF12895.7 ETO02783.1 - 9.4e-05 22.6 12.3 0.0012 19.1 5.1 2.9 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ETO02783.1 - 0.00017 21.1 6.6 0.00058 19.4 6.6 1.8 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETO02783.1 - 0.00027 21.0 5.7 0.11 12.7 0.1 3.7 3 1 0 3 3 3 1 PPR repeat DUF2225 PF09986.9 ETO02783.1 - 0.0003 20.6 9.0 0.0011 18.8 2.2 2.0 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) RPN7 PF10602.9 ETO02783.1 - 0.00039 20.2 6.7 0.13 11.9 1.1 2.9 1 1 2 3 3 3 2 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 ETO02783.1 - 0.0015 17.9 1.8 0.63 9.5 0.1 3.2 4 0 0 4 4 4 1 SHNi-TPR TetR_C_19 PF17924.1 ETO02783.1 - 0.0021 18.6 2.8 0.096 13.3 0.0 2.9 3 0 0 3 3 3 1 Tetracyclin repressor-like, C-terminal domain Prefoldin PF02996.17 ETO02783.1 - 0.0065 16.4 3.4 0.6 10.0 0.3 3.0 2 1 1 3 3 3 1 Prefoldin subunit Sel1 PF08238.12 ETO02783.1 - 0.01 16.5 0.5 1.1 10.0 0.0 3.4 3 1 0 3 3 3 0 Sel1 repeat HTH_Bact PF18768.1 ETO02783.1 - 0.012 15.2 1.1 7.3 6.3 0.2 3.3 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain MIT PF04212.18 ETO02783.1 - 0.012 15.7 1.1 0.012 15.7 1.1 3.5 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO02783.1 - 0.022 15.3 2.4 0.17 12.4 0.7 2.8 2 2 1 3 3 3 0 Tetratricopeptide repeat NSF PF02071.20 ETO02783.1 - 0.043 14.5 7.3 3.6 8.7 0.4 4.5 4 0 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_9 PF13371.6 ETO02783.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETO02783.1 - 0.1 12.6 1.5 0.7 10.0 1.5 2.2 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) SMBP PF16785.5 ETO02783.1 - 0.11 12.7 0.1 2.7 8.3 0.0 2.6 2 2 1 3 3 3 0 Small metal-binding protein SPO22 PF08631.10 ETO02783.1 - 1.1 8.6 11.9 1.8 8.0 0.5 3.0 1 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like PPR_2 PF13041.6 ETO02783.1 - 1.8 8.8 6.8 5.7 7.2 0.2 3.2 3 0 0 3 3 3 0 PPR repeat family TPR_11 PF13414.6 ETO02784.1 - 8.1e-14 51.0 0.1 1.9e-05 24.2 0.1 3.1 3 0 0 3 3 3 3 TPR repeat TPR_1 PF00515.28 ETO02784.1 - 2.8e-11 42.7 2.8 0.0029 17.3 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02784.1 - 2.1e-09 37.1 0.7 0.006 16.9 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02784.1 - 3.1e-06 26.9 0.6 1.1 9.5 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO02784.1 - 7.5e-06 26.1 0.5 0.048 14.0 0.2 2.7 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02784.1 - 1.8e-05 25.2 0.2 0.071 14.0 0.0 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02784.1 - 1.9e-05 24.5 0.0 0.34 11.3 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO02784.1 - 3.7e-05 24.1 0.0 0.43 11.1 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02784.1 - 0.024 14.6 0.1 14 6.0 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02784.1 - 0.024 14.5 1.2 5.2 7.1 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02784.1 - 0.044 14.4 0.3 0.85 10.3 0.2 2.1 1 1 2 3 3 3 0 Tetratricopeptide repeat Phage_int_SAM_4 PF13495.6 ETO02785.1 - 0.0013 19.1 0.5 0.0048 17.3 0.5 2.0 1 1 1 2 2 2 1 Phage integrase, N-terminal SAM-like domain Cadherin_C PF01049.17 ETO02785.1 - 0.0015 18.9 0.3 0.0022 18.3 0.3 1.2 1 0 0 1 1 1 1 Cadherin cytoplasmic region PspB PF06667.12 ETO02785.1 - 0.18 11.8 3.6 5.5 7.1 1.3 2.4 2 1 0 2 2 2 0 Phage shock protein B zf-TRAF PF02176.18 ETO02786.1 - 0.00022 21.8 8.2 0.00022 21.8 8.2 2.8 3 1 1 4 4 4 1 TRAF-type zinc finger HEAT PF02985.22 ETO02787.1 - 3.7e-07 29.9 0.2 0.00026 21.0 0.0 3.3 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ETO02787.1 - 4.1e-05 23.9 0.0 0.024 15.0 0.0 2.0 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETO02787.1 - 0.00017 21.7 0.2 0.0085 16.2 0.1 2.1 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO02787.1 - 0.00022 21.7 0.1 0.027 15.0 0.0 2.1 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO02787.1 - 0.00098 18.8 0.1 0.0025 17.4 0.0 1.6 1 1 0 1 1 1 1 CLASP N terminal HEAT_EZ PF13513.6 ETO02787.1 - 0.0017 18.8 0.1 0.029 14.9 0.0 2.3 2 0 0 2 2 2 1 HEAT-like repeat Adaptin_N PF01602.20 ETO02787.1 - 0.0044 15.6 0.1 0.0048 15.5 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cas_Csm6 PF09659.10 ETO02787.1 - 0.016 14.0 0.1 0.024 13.4 0.1 1.2 1 1 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) TIP120 PF08623.10 ETO02787.1 - 0.026 14.3 0.3 1.3 8.8 0.0 2.2 1 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) SRA1 PF07304.11 ETO02787.1 - 0.063 13.1 0.3 0.097 12.5 0.3 1.3 1 0 0 1 1 1 0 Steroid receptor RNA activator (SRA1) Med23 PF11573.8 ETO02787.1 - 0.086 10.5 0.0 0.094 10.4 0.0 1.0 1 0 0 1 1 1 0 Mediator complex subunit 23 DUF2262 PF10020.9 ETO02787.1 - 0.099 13.0 1.2 1.6 9.1 0.3 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2262) DUF5071 PF16804.5 ETO02787.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5071) WD40 PF00400.32 ETO02788.1 - 3.5e-12 46.6 15.1 1e-06 29.3 0.8 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02788.1 - 8e-05 21.5 1.1 0.064 11.9 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 W_rich_C PF07483.11 ETO02788.1 - 0.041 14.0 0.3 0.077 13.2 0.1 1.5 1 1 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain DUF4666 PF15697.5 ETO02794.1 - 0.11 13.2 0.1 0.27 11.9 0.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4666) MIOX PF05153.15 ETO02796.1 - 3.2e-09 36.7 1.3 3.2e-09 36.7 1.3 1.3 2 0 0 2 2 2 1 Myo-inositol oxygenase DUF262 PF03235.14 ETO02796.1 - 0.09 12.9 5.6 0.1 12.7 5.6 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF262 cwf18 PF08315.12 ETO02796.1 - 0.097 13.3 6.4 0.12 13.1 6.4 1.2 1 0 0 1 1 1 0 cwf18 pre-mRNA splicing factor TMEM132D_C PF15706.5 ETO02798.1 - 0.097 12.5 0.4 0.31 10.9 0.4 1.9 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term YojJ PF10372.9 ETO02800.1 - 0.014 15.5 0.0 0.081 13.0 0.0 2.1 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus TPR_12 PF13424.6 ETO02802.1 - 6.7e-12 45.5 0.0 3.1e-10 40.2 0.0 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02802.1 - 3.2e-10 39.5 0.1 2.8e-07 30.2 0.0 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02802.1 - 2.4e-07 30.3 5.7 3.7e-07 29.7 0.6 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02802.1 - 4.6e-07 29.4 0.0 1.3e-06 28.0 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02802.1 - 1.1e-05 25.3 0.9 1.1e-05 25.3 0.9 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02802.1 - 8.4e-05 22.4 1.3 0.00047 20.1 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02802.1 - 0.014 15.7 2.1 19 5.9 0.0 3.7 2 1 1 3 3 3 0 Tetratricopeptide repeat Kelch_4 PF13418.6 ETO02803.1 - 0.15 12.1 0.1 8.7 6.5 0.0 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain FRB_dom PF08771.11 ETO02804.1 - 0.0036 17.7 0.2 0.0088 16.4 0.2 1.7 1 0 0 1 1 1 1 FKBP12-rapamycin binding domain DUF2369 PF10179.9 ETO02805.1 - 0.1 13.0 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) Sec34 PF04136.15 ETO02806.1 - 0.0011 18.9 3.6 0.0011 18.9 3.6 1.7 2 0 0 2 2 2 1 Sec34-like family Glyco_hydro_36N PF16875.5 ETO02806.1 - 0.044 13.3 0.7 0.049 13.2 0.7 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 36 N-terminal domain Got1 PF04178.12 ETO02807.1 - 0.0095 16.3 3.6 0.0095 16.3 3.6 1.8 2 0 0 2 2 1 1 Got1/Sft2-like family DUF3671 PF12420.8 ETO02807.1 - 0.017 15.2 0.2 0.017 15.2 0.2 3.9 4 1 0 4 4 4 0 Protein of unknown function DUF1129 PF06570.11 ETO02807.1 - 0.024 14.2 0.5 0.024 14.2 0.5 2.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1129) Phage_Gp23 PF10669.9 ETO02807.1 - 0.032 14.6 12.9 1.1 9.5 0.8 3.7 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) Pox_A14 PF05767.12 ETO02807.1 - 0.1 12.8 2.6 0.29 11.3 1.8 2.2 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 Peptidase_U4 PF03419.13 ETO02807.1 - 0.42 9.9 6.7 0.14 11.4 3.2 2.0 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Wzy_C PF04932.15 ETO02807.1 - 0.42 10.2 3.7 1.5 8.4 3.1 2.0 2 0 0 2 2 2 0 O-Antigen ligase FAM176 PF14851.6 ETO02807.1 - 0.64 9.7 11.1 0.31 10.7 1.4 3.2 3 0 0 3 3 3 0 FAM176 family HNOBA PF07701.14 ETO02807.1 - 0.72 9.2 10.8 0.13 11.7 3.8 2.5 2 0 0 2 2 2 0 Heme NO binding associated DUF4611 PF15387.6 ETO02807.1 - 0.79 10.0 16.5 0.21 11.8 6.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) Dynein_AAA_lid PF17852.1 ETO02807.1 - 1.2 9.3 5.0 1.2 9.2 1.3 3.0 2 0 0 2 2 2 0 Dynein heavy chain AAA lid domain Vfa1 PF08432.10 ETO02807.1 - 4.9 7.4 23.4 0.14 12.5 6.0 3.4 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 Peptidase_C48 PF02902.19 ETO02808.1 - 1e-18 68.0 2.5 1e-18 68.0 2.5 1.7 2 1 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain DUF5426 PF17473.2 ETO02808.1 - 0.19 12.0 3.4 2.8 8.2 1.6 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5426) TssO PF17561.2 ETO02810.1 - 0.55 10.3 8.5 0.33 11.0 5.1 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO Kinesin PF00225.23 ETO02811.1 - 3.4e-31 108.4 0.2 3.9e-31 108.2 0.2 1.0 1 0 0 1 1 1 1 Kinesin motor domain Sugar_tr PF00083.24 ETO02812.1 - 2.1e-20 73.1 1.5 2.1e-20 73.1 1.5 1.8 2 0 0 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ETO02812.1 - 0.034 13.1 9.2 0.053 12.4 9.2 1.3 1 1 0 1 1 1 0 Major Facilitator Superfamily ODV-E18 PF10717.9 ETO02812.1 - 0.18 11.7 0.5 0.77 9.7 0.0 2.1 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 zf-C2H2_6 PF13912.6 ETO02813.1 - 0.05 13.6 0.7 0.05 13.6 0.7 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger Baculo_VP39 PF04501.12 ETO02815.1 - 0.0024 17.4 0.8 0.0046 16.5 0.8 1.4 1 0 0 1 1 1 1 Baculovirus major capsid protein VP39 UCH PF00443.29 ETO02817.1 - 4.8e-11 42.7 0.1 6e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GRP PF07172.11 ETO02817.1 - 0.0032 18.1 7.9 0.0043 17.7 7.9 1.2 1 0 0 1 1 1 1 Glycine rich protein family MOR2-PAG1_N PF14222.6 ETO02817.1 - 0.089 11.7 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 Cell morphogenesis N-terminal RRM_1 PF00076.22 ETO02818.1 - 1.1e-07 31.6 0.0 3.7e-07 29.9 0.0 2.0 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RSB_motif PF16294.5 ETO02818.1 - 9e-06 25.9 1.4 9e-06 25.9 1.4 6.1 5 2 1 6 6 6 1 RNSP1-SAP18 binding (RSB) motif SET_assoc PF11767.8 ETO02818.1 - 0.032 13.9 0.0 0.075 12.7 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated EFG_IV PF03764.18 ETO02818.1 - 0.32 10.8 3.9 3 7.6 3.6 2.5 2 0 0 2 2 2 0 Elongation factor G, domain IV Pkinase PF00069.25 ETO02819.1 - 9.1e-17 61.3 5.4 7.5e-16 58.3 5.4 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO02819.1 - 1e-12 47.9 1.2 3.2e-06 26.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase RAP1 PF07218.11 ETO02819.1 - 0.0014 17.1 24.1 0.0015 17.0 24.1 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) Kinase-like PF14531.6 ETO02819.1 - 0.014 14.7 1.6 1.5 8.1 0.0 2.1 2 0 0 2 2 2 0 Kinase-like SANTA PF09133.10 ETO02819.1 - 0.021 15.3 0.1 0.05 14.1 0.1 1.6 1 0 0 1 1 1 0 SANTA (SANT Associated) APH PF01636.23 ETO02819.1 - 0.23 11.3 0.0 0.3 11.0 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ndc1_Nup PF09531.10 ETO02819.1 - 0.49 9.0 8.5 0.54 8.9 8.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAC1F_C PF16885.5 ETO02819.1 - 0.83 9.2 10.6 0.89 9.2 10.6 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term AF-4 PF05110.13 ETO02819.1 - 1.5 6.8 33.7 2.5 6.1 33.7 1.3 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PglL_A PF15864.5 ETO02820.1 - 0.045 13.5 0.1 0.1 12.4 0.1 1.6 1 0 0 1 1 1 0 Protein glycosylation ligase XFP_C PF09363.10 ETO02822.1 - 0.045 13.2 0.0 0.061 12.8 0.0 1.2 1 0 0 1 1 1 0 XFP C-terminal domain DUF1213 PF06740.12 ETO02822.1 - 1.7 9.3 3.9 8 7.1 2.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) WD40 PF00400.32 ETO02823.1 - 3.7e-09 37.1 0.1 9.7e-09 35.7 0.1 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat Spc7 PF08317.11 ETO02823.1 - 0.00097 18.1 9.8 0.0012 17.9 9.8 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Nup160 PF11715.8 ETO02823.1 - 0.002 16.8 0.4 0.006 15.3 0.0 1.7 1 1 0 2 2 2 1 Nucleoporin Nup120/160 HMMR_N PF15905.5 ETO02823.1 - 0.0069 15.9 15.3 0.0089 15.5 15.3 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal PEARLI-4 PF05278.12 ETO02823.1 - 0.009 15.6 8.0 0.01 15.4 8.0 1.2 1 0 0 1 1 1 1 Arabidopsis phospholipase-like protein (PEARLI 4) Vfa1 PF08432.10 ETO02823.1 - 0.014 15.7 10.7 0.018 15.4 10.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF16 PF01519.16 ETO02823.1 - 0.015 15.8 10.5 0.023 15.2 10.5 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 TMF_DNA_bd PF12329.8 ETO02823.1 - 0.02 14.9 20.2 0.037 14.0 20.2 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 DNA binding HSD3 PF15244.6 ETO02823.1 - 0.021 14.4 6.3 0.023 14.2 6.3 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 PIEZO PF15917.5 ETO02823.1 - 0.024 14.1 5.6 0.029 13.9 5.6 1.1 1 0 0 1 1 1 0 Piezo DDHD PF02862.17 ETO02823.1 - 0.029 14.5 2.4 0.042 14.0 2.4 1.2 1 0 0 1 1 1 0 DDHD domain LMBR1 PF04791.16 ETO02823.1 - 0.029 13.3 3.4 0.028 13.3 3.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 ETO02823.1 - 0.042 14.2 12.8 0.058 13.7 12.8 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF3552 PF12072.8 ETO02823.1 - 0.051 13.0 13.3 0.064 12.7 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) GCD14 PF08704.10 ETO02823.1 - 0.068 12.8 4.1 0.085 12.5 4.1 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Connexin PF00029.19 ETO02823.1 - 0.11 12.2 2.1 0.12 12.1 2.1 1.1 1 0 0 1 1 1 0 Connexin Cytomega_UL84 PF06284.11 ETO02823.1 - 0.23 9.9 0.9 0.28 9.6 0.9 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein FAM76 PF16046.5 ETO02823.1 - 0.25 10.7 10.8 0.35 10.2 10.8 1.2 1 0 0 1 1 1 0 FAM76 protein TRAP-gamma PF07074.12 ETO02823.1 - 0.25 10.9 4.4 0.35 10.4 4.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) PPL5 PF18168.1 ETO02823.1 - 0.26 10.5 5.2 0.32 10.3 5.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF724 PF05266.14 ETO02823.1 - 0.26 11.1 13.0 0.36 10.6 13.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) TMPIT PF07851.13 ETO02823.1 - 0.61 9.3 7.8 0.73 9.0 7.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein FemAB PF02388.16 ETO02823.1 - 0.65 8.8 9.5 0.82 8.5 9.5 1.1 1 0 0 1 1 1 0 FemAB family Atg14 PF10186.9 ETO02823.1 - 0.94 8.5 10.3 1.1 8.3 10.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CLN3 PF02487.17 ETO02823.1 - 1 8.3 3.4 1.3 8.0 3.4 1.0 1 0 0 1 1 1 0 CLN3 protein DUF3450 PF11932.8 ETO02823.1 - 1.1 8.5 8.4 1.4 8.2 8.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) YabA PF06156.13 ETO02823.1 - 1.2 9.8 9.7 2.1 9.0 9.7 1.4 1 0 0 1 1 1 0 Initiation control protein YabA EMC3_TMCO1 PF01956.16 ETO02823.1 - 1.7 8.3 5.7 2.1 8.0 5.7 1.2 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF4407 PF14362.6 ETO02823.1 - 3.1 7.1 6.6 4 6.7 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 ETO02823.1 - 4 7.5 8.1 4.9 7.2 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) HEAT PF02985.22 ETO02824.1 - 5.7e-06 26.1 0.0 0.00026 21.0 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ETO02824.1 - 6.8e-06 26.4 0.0 0.051 14.0 0.0 2.3 2 0 0 2 2 2 2 HEAT repeats Imm70 PF15601.6 ETO02824.1 - 0.0011 18.5 0.2 0.52 9.9 0.1 2.9 2 1 1 3 3 3 2 Immunity protein 70 Vac14_Fab1_bd PF12755.7 ETO02824.1 - 0.017 15.7 0.2 1.4 9.6 0.0 3.2 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region RPT PF13446.6 ETO02824.1 - 0.026 14.4 2.0 0.4 10.6 0.1 3.3 2 1 1 3 3 3 0 A repeated domain in UCH-protein SAC3_GANP PF03399.16 ETO02824.1 - 0.085 12.2 6.5 1 8.7 0.2 3.1 3 1 1 4 4 4 0 SAC3/GANP family DUF5614 PF18474.1 ETO02826.1 - 0.12 11.7 0.5 0.17 11.1 0.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5614) DUF2483 PF10656.9 ETO02827.1 - 0.048 13.8 1.0 0.084 13.1 1.0 1.4 1 0 0 1 1 1 0 Hypothetical protein of unknown function (DUF2483) RED_C PF07807.11 ETO02828.1 - 0.0091 16.5 1.2 0.012 16.1 1.2 1.3 1 0 0 1 1 1 1 RED-like protein C-terminal region EFTUD2 PF16004.5 ETO02828.1 - 0.022 15.4 0.6 0.026 15.1 0.6 1.1 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus ETRAMP PF09716.10 ETO02831.1 - 0.029 14.4 1.0 0.054 13.6 1.0 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) GPS PF01825.21 ETO02831.1 - 0.045 14.3 2.2 0.045 14.3 2.2 2.6 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif DUF3149 PF11346.8 ETO02831.1 - 0.25 11.0 1.1 0.65 9.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) CutC PF03932.14 ETO02833.1 - 0.036 13.5 0.3 0.17 11.3 0.2 2.0 2 0 0 2 2 2 0 CutC family Helicase_C PF00271.31 ETO02833.1 - 0.047 14.0 0.9 0.29 11.5 0.2 2.7 2 1 0 2 2 2 0 Helicase conserved C-terminal domain HNF-1_N PF04814.13 ETO02833.1 - 0.056 14.1 0.6 0.056 14.1 0.6 2.4 3 0 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus UXS1_N PF11803.8 ETO02833.1 - 0.59 10.5 3.0 31 5.0 0.3 3.6 3 0 0 3 3 3 0 UDP-glucuronate decarboxylase N-terminal Ribonuc_L-PSP PF01042.21 ETO02833.1 - 0.94 9.5 5.1 2.5 8.1 0.3 3.3 2 1 1 3 3 3 0 Endoribonuclease L-PSP DcpS_C PF11969.8 ETO02835.1 - 2.3e-09 37.7 0.2 5.6e-09 36.5 0.2 1.6 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ETO02835.1 - 4.9e-08 33.6 0.1 1.3e-07 32.3 0.1 1.6 1 0 0 1 1 1 1 HIT domain Atg14 PF10186.9 ETO02835.1 - 0.00062 19.0 0.7 0.00098 18.3 0.7 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 zf-P11 PF03854.14 ETO02836.1 - 0.94 9.2 7.3 4.5 7.0 1.7 2.7 3 0 0 3 3 3 0 P-11 zinc finger CENP-F_leu_zip PF10473.9 ETO02838.1 - 0.00072 19.6 26.2 0.048 13.7 12.9 2.5 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sugarporin_N PF11471.8 ETO02838.1 - 0.011 15.7 0.0 0.023 14.6 0.0 1.5 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension Tropomyosin PF00261.20 ETO02838.1 - 0.069 12.5 20.5 0.014 14.8 7.4 2.2 1 1 1 2 2 2 0 Tropomyosin CALCOCO1 PF07888.11 ETO02838.1 - 0.27 10.0 24.0 0.41 9.5 24.0 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like ATG16 PF08614.11 ETO02838.1 - 0.35 11.1 28.8 0.7 10.1 20.4 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4349 PF14257.6 ETO02838.1 - 0.4 10.1 3.5 0.26 10.7 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) HalX PF08663.10 ETO02838.1 - 0.71 10.2 4.3 5.5 7.4 0.4 3.2 2 1 1 3 3 3 0 HalX domain Laminin_II PF06009.12 ETO02838.1 - 1.3 9.1 14.6 0.06 13.4 5.9 2.3 1 1 1 2 2 2 0 Laminin Domain II ADIP PF11559.8 ETO02838.1 - 1.4 9.0 37.0 2.3 8.3 16.8 2.8 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4763 PF15960.5 ETO02838.1 - 2.4 7.4 30.5 0.053 12.8 7.4 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4763) Mod_r PF07200.13 ETO02838.1 - 4.2 7.5 29.4 0.19 11.8 9.4 2.5 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein APG6_N PF17675.1 ETO02838.1 - 5.3 7.6 33.6 8.9 6.9 7.2 3.3 1 1 1 3 3 3 0 Apg6 coiled-coil region DUF4407 PF14362.6 ETO02838.1 - 6.7 6.0 21.5 18 4.5 21.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 ETO02838.1 - 8.2 6.2 22.7 7.2 6.4 8.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) HSP70 PF00012.20 ETO02840.1 - 0.0019 16.5 0.3 0.0019 16.5 0.3 1.0 1 0 0 1 1 1 1 Hsp70 protein DDR PF08841.10 ETO02840.1 - 0.021 13.8 0.5 0.047 12.7 0.1 1.6 1 1 1 2 2 2 0 Diol dehydratase reactivase ATPase-like domain Hydantoinase_A PF01968.18 ETO02840.1 - 0.11 11.7 0.0 0.11 11.7 0.0 1.1 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase EutA PF06277.11 ETO02840.1 - 0.13 11.1 0.0 0.13 11.1 0.0 1.0 1 0 0 1 1 1 0 Ethanolamine utilisation protein EutA BcrAD_BadFG PF01869.20 ETO02841.1 - 0.013 15.0 0.0 0.018 14.5 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DUF4796 PF16044.5 ETO02841.1 - 0.055 13.1 0.2 0.36 10.4 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4796) Condensin2nSMC PF12422.8 ETO02842.1 - 0.023 14.9 0.6 0.05 13.8 0.6 1.7 1 1 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit MIEAP PF16026.5 ETO02842.1 - 0.027 14.7 0.4 0.074 13.3 0.4 1.9 1 1 0 1 1 1 0 Mitochondria-eating protein TPR_MLP1_2 PF07926.12 ETO02843.1 - 0.024 14.7 38.4 0.36 10.9 13.3 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF16 PF01519.16 ETO02843.1 - 0.21 12.1 42.5 2.1 8.9 19.0 3.5 1 1 2 3 3 3 0 Protein of unknown function DUF16 DUF416 PF04222.12 ETO02843.1 - 0.23 10.9 25.5 0.43 10.0 8.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF416) V_ATPase_I PF01496.19 ETO02843.1 - 1.3 6.8 23.7 1.6 6.6 23.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family VirE PF05272.11 ETO02843.1 - 2.3 7.9 11.9 0.088 12.5 4.2 2.1 1 1 0 2 2 2 0 Virulence-associated protein E Seryl_tRNA_N PF02403.22 ETO02843.1 - 2.6 8.3 36.3 0.11 12.8 22.5 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.9 ETO02843.1 - 2.8 8.3 34.4 2.4 8.5 5.2 3.4 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF5401 PF17380.2 ETO02843.1 - 3.1 5.7 30.5 4 5.4 30.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5401) TMF_DNA_bd PF12329.8 ETO02843.1 - 3.2 7.8 44.8 0.11 12.6 10.4 4.0 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF948 PF06103.11 ETO02843.1 - 3.3 8.0 17.5 26 5.2 9.4 3.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Mannitol_dh PF01232.23 ETO02843.1 - 4.5 7.4 16.5 0.37 11.0 3.2 2.7 1 1 2 3 3 3 0 Mannitol dehydrogenase Rossmann domain ATG16 PF08614.11 ETO02843.1 - 4.6 7.4 33.6 17 5.6 33.4 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CHASE3 PF05227.13 ETO02843.1 - 4.6 7.2 17.2 0.2 11.5 4.4 2.6 1 1 2 3 3 3 0 CHASE3 domain ADIP PF11559.8 ETO02843.1 - 5 7.2 38.9 6 6.9 18.0 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding ALMT PF11744.8 ETO02843.1 - 5.3 5.7 22.5 6.5 5.5 22.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SlyX PF04102.12 ETO02843.1 - 5.5 7.7 26.6 1.7 9.3 6.8 3.9 1 1 3 4 4 4 0 SlyX DUF2203 PF09969.9 ETO02843.1 - 9.8 6.9 22.5 2.9 8.6 7.9 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) CUE PF02845.16 ETO02844.1 - 0.0009 18.9 0.0 0.0036 17.0 0.0 2.1 2 0 0 2 2 2 1 CUE domain RelA_SpoT PF04607.17 ETO02844.1 - 0.079 13.2 0.2 0.079 13.2 0.2 2.6 3 0 0 3 3 3 0 Region found in RelA / SpoT proteins DUF2239 PF09998.9 ETO02844.1 - 0.08 12.7 0.2 0.14 11.9 0.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2239) DUF1664 PF07889.12 ETO02844.1 - 3.2 7.8 6.2 1.1 9.3 3.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FAD_binding_2 PF00890.24 ETO02845.1 - 3.9e-27 95.4 0.3 4.6e-27 95.2 0.3 1.0 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETO02845.1 - 5e-09 36.2 0.2 5.6e-09 36.0 0.2 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ETO02845.1 - 1.4e-08 34.6 0.1 1.4e-08 34.5 0.1 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ETO02845.1 - 1.9e-05 23.9 0.3 2.2e-05 23.8 0.3 1.1 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ETO02845.1 - 2.2e-05 23.9 0.1 2.3e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETO02845.1 - 2.5e-05 23.7 0.0 2.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ETO02845.1 - 4.7e-05 23.5 1.4 4.7e-05 23.5 1.4 2.1 2 1 0 2 2 2 1 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ETO02845.1 - 0.00025 19.9 2.1 0.00035 19.4 2.0 1.3 1 1 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 ETO02845.1 - 0.00053 19.3 0.1 0.0006 19.1 0.1 1.2 1 0 0 1 1 1 1 Thi4 family Pyr_redox_3 PF13738.6 ETO02845.1 - 0.0031 16.8 0.1 0.004 16.5 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO02845.1 - 0.01 16.4 0.6 0.017 15.7 0.6 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ETO02845.1 - 0.021 14.7 0.3 0.027 14.4 0.3 1.1 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ETO02845.1 - 0.064 13.7 0.0 0.088 13.3 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding YcgL PF05166.13 ETO02846.1 - 0.3 11.5 1.5 0.5 10.7 0.2 2.0 2 0 0 2 2 2 0 YcgL domain EOS1 PF12326.8 ETO02848.1 - 0.74 9.7 2.8 0.9 9.5 2.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein Zip PF02535.22 ETO02848.1 - 1.1 8.4 4.2 1.3 8.1 4.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO02848.1 - 2.5 8.1 7.8 2.8 7.9 7.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RHD3 PF05879.12 ETO02849.1 - 7.9e-17 60.7 0.1 7.9e-17 60.7 0.1 2.2 2 1 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ETO02849.1 - 4.6e-10 39.2 0.1 4.6e-10 39.2 0.1 2.0 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain MMR_HSR1 PF01926.23 ETO02849.1 - 1.4e-06 28.4 0.3 4.2e-06 26.8 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETO02849.1 - 0.0064 16.6 0.1 0.0064 16.6 0.1 2.9 3 2 1 4 4 4 1 Dynamin family AAA_28 PF13521.6 ETO02849.1 - 0.0071 16.6 0.0 0.015 15.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO02849.1 - 0.015 15.7 0.0 0.093 13.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 ETO02849.1 - 0.77 10.3 0.0 0.77 10.3 0.0 2.7 2 1 0 2 2 2 0 ABC transporter OSCP PF00213.18 ETO02849.1 - 0.84 9.7 5.9 0.65 10.1 3.8 1.9 2 0 0 2 2 2 0 ATP synthase delta (OSCP) subunit Gly-zipper_Omp PF13488.6 ETO02850.1 - 3e-12 46.3 157.3 0.093 12.7 2.6 8.7 1 1 3 4 4 4 2 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO02850.1 - 4.8e-05 23.0 119.9 0.002 17.8 5.8 8.2 1 1 5 6 6 6 4 YMGG-like Gly-zipper Importin_rep PF18773.1 ETO02851.1 - 0.019 14.6 0.3 0.049 13.3 0.3 1.7 1 0 0 1 1 1 0 Importin 13 repeat Importin_rep PF18773.1 ETO02852.1 - 0.066 12.9 0.3 0.19 11.5 0.3 1.8 1 0 0 1 1 1 0 Importin 13 repeat Cytochrom_c3_2 PF14537.6 ETO02853.1 - 0.031 14.8 12.4 0.12 12.9 12.4 2.0 1 0 0 1 1 1 0 Cytochrome c3 zf-CCHC PF00098.23 ETO02853.1 - 0.052 13.6 2.2 0.14 12.3 2.2 1.8 1 0 0 1 1 1 0 Zinc knuckle FerB PF08150.12 ETO02853.1 - 0.088 13.4 1.9 1.4 9.6 0.0 3.4 2 1 1 3 3 3 0 FerB (NUC096) domain SelB-wing_3 PF09107.11 ETO02854.1 - 0.13 11.9 0.1 0.25 11.0 0.1 1.5 1 0 0 1 1 1 0 Elongation factor SelB, winged helix DUF3189 PF11385.8 ETO02856.1 - 0.09 12.6 0.1 0.25 11.2 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3189) RPN2_C PF18004.1 ETO02860.1 - 3.2e-11 43.4 3.9 4e-11 43.1 3.9 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Dynein_AAA_lid PF17852.1 ETO02862.1 - 0.17 11.9 1.3 0.34 11.0 0.5 2.0 2 1 0 2 2 2 0 Dynein heavy chain AAA lid domain Methyltransf_31 PF13847.6 ETO02863.1 - 1.8e-05 24.6 0.4 3.4e-05 23.7 0.2 1.5 1 1 1 2 2 2 1 Methyltransferase domain MTS PF05175.14 ETO02863.1 - 0.00011 21.8 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ETO02863.1 - 0.0011 19.6 0.2 0.0048 17.6 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO02863.1 - 0.024 14.0 0.2 0.17 11.2 0.1 1.9 1 1 1 2 2 2 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ETO02863.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase UNC80 PF15778.5 ETO02864.1 - 0.028 14.0 0.7 0.038 13.6 0.7 1.3 1 0 0 1 1 1 0 Cation channel complex component UNC80 UPF0542 PF15086.6 ETO02864.1 - 1.2 9.1 5.6 6.2 6.8 1.1 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 GHL6 PF14871.6 ETO02865.1 - 0.08 13.1 0.3 0.12 12.5 0.3 1.3 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 Bromodomain PF00439.25 ETO02865.1 - 0.11 12.5 1.1 0.58 10.3 0.1 2.3 2 0 0 2 2 2 0 Bromodomain Bromodomain PF00439.25 ETO02868.1 - 1.2e-10 41.3 0.1 3.2e-10 40.0 0.1 1.7 1 0 0 1 1 1 1 Bromodomain NAM-associated PF14303.6 ETO02868.1 - 0.02 15.6 7.1 0.029 15.1 7.1 1.2 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain Kelch_5 PF13854.6 ETO02869.1 - 0.0024 17.8 0.1 0.054 13.5 0.0 2.2 2 0 0 2 2 2 1 Kelch motif BP28CT PF08146.12 ETO02869.1 - 0.031 14.1 0.2 0.04 13.7 0.2 1.1 1 0 0 1 1 1 0 BP28CT (NUC211) domain P63C PF10546.9 ETO02869.1 - 0.047 14.3 0.1 0.093 13.3 0.1 1.5 1 0 0 1 1 1 0 P63C domain Kelch_6 PF13964.6 ETO02869.1 - 0.059 13.7 0.0 0.098 13.0 0.0 1.3 1 0 0 1 1 1 0 Kelch motif GILT PF03227.16 ETO02872.1 - 0.15 12.3 1.2 0.23 11.7 0.3 1.8 2 0 0 2 2 2 0 Gamma interferon inducible lysosomal thiol reductase (GILT) Kelch_1 PF01344.25 ETO02873.1 - 0.00011 21.7 0.7 0.0028 17.2 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO02873.1 - 0.00037 20.4 0.2 0.0075 16.2 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO02873.1 - 0.35 11.2 2.3 14 6.2 0.1 2.2 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO02874.1 - 4.7e-13 49.4 11.7 5.8e-08 33.3 1.3 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02874.1 - 0.00035 19.4 1.6 0.036 12.7 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO02874.1 - 0.0056 16.1 0.6 0.0094 15.3 0.6 1.5 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO02874.1 - 0.046 14.0 0.4 0.29 11.5 0.0 2.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_12 PF13424.6 ETO02875.1 - 9.5e-38 128.4 9.8 8.3e-18 64.5 0.7 3.0 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02875.1 - 4.4e-24 83.6 0.1 2.4e-08 33.6 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02875.1 - 7e-12 44.6 14.3 2.7e-06 27.0 1.2 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02875.1 - 1.3e-11 43.7 9.2 0.00016 21.5 0.5 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02875.1 - 5.7e-08 32.3 0.9 0.0068 16.4 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02875.1 - 4.7e-07 29.5 17.3 0.0026 17.8 0.5 3.4 3 1 0 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.6 ETO02875.1 - 6.3e-05 22.5 0.8 7.5e-05 22.3 0.8 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO02875.1 - 0.0014 19.1 1.2 5.3 7.9 0.1 3.6 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO02875.1 - 0.0019 18.4 1.0 0.93 10.0 0.4 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02875.1 - 0.005 16.5 0.3 0.005 16.5 0.3 4.2 3 2 2 5 5 5 1 TPR repeat TPR_16 PF13432.6 ETO02875.1 - 0.018 15.7 0.0 9.4 7.0 0.0 2.7 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02875.1 - 0.019 14.8 7.4 0.73 9.6 0.4 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 ETO02875.1 - 0.029 13.8 0.1 2.8 7.4 0.0 3.0 3 0 0 3 3 3 0 SHNi-TPR DUF2225 PF09986.9 ETO02875.1 - 0.032 14.0 5.2 0.064 13.0 5.2 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2225) Inhibitor_I29 PF08246.12 ETO02875.1 - 0.069 13.6 8.4 2.2 8.8 0.5 3.0 3 0 0 3 3 3 0 Cathepsin propeptide inhibitor domain (I29) ARID PF01388.21 ETO02876.1 - 0.00076 20.1 0.2 0.0016 19.0 0.2 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain MADF_DNA_bdg PF10545.9 ETO02876.1 - 0.026 14.9 0.2 0.05 13.9 0.2 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like ETRAMP PF09716.10 ETO02876.1 - 0.13 12.4 0.3 0.4 10.8 0.1 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) RXT2_N PF08595.11 ETO02876.1 - 0.25 11.4 6.3 0.39 10.7 6.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 ETO02876.1 - 0.28 10.5 10.7 0.37 10.1 10.7 1.1 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 ETO02876.1 - 5.1 6.1 11.5 6.2 5.9 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) ARID PF01388.21 ETO02877.1 - 0.00074 20.1 0.2 0.0016 19.0 0.2 1.5 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain MADF_DNA_bdg PF10545.9 ETO02877.1 - 0.026 14.8 0.2 0.049 13.9 0.2 1.4 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like NOA36 PF06524.12 ETO02877.1 - 0.77 9.0 9.8 1 8.7 9.8 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO02877.1 - 10 6.6 11.2 0.39 11.1 3.8 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4889 PF16230.5 ETO02878.1 - 0.05 13.8 8.3 0.11 12.8 8.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4889) JmjN PF02375.17 ETO02879.1 - 0.089 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 jmjN domain Secretin_N_2 PF07655.13 ETO02883.1 - 0.34 11.5 13.5 1.2 9.8 4.5 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain DUF817 PF05675.12 ETO02884.1 - 0.25 11.0 0.4 0.46 10.1 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF817) Ribosomal_S17e PF00833.18 ETO02884.1 - 3.2 7.7 7.3 0.37 10.7 0.4 2.9 3 0 0 3 3 3 0 Ribosomal S17 Ribosomal_S17e PF00833.18 ETO02885.1 - 0.02 14.8 0.9 0.12 12.2 0.5 2.1 2 0 0 2 2 2 0 Ribosomal S17 DUF3222 PF11519.8 ETO02887.1 - 0.049 13.9 0.7 0.071 13.3 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3222) HEAT PF02985.22 ETO02890.1 - 4.9e-13 48.1 0.3 0.066 13.5 0.0 7.9 8 0 0 8 8 7 3 HEAT repeat HEAT_2 PF13646.6 ETO02890.1 - 1.1e-12 48.1 0.0 0.0021 18.4 0.0 4.8 3 1 1 5 5 5 3 HEAT repeats Cnd1 PF12717.7 ETO02890.1 - 4e-09 36.7 21.7 0.0048 16.9 0.1 6.5 1 1 6 7 7 7 4 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETO02890.1 - 2.3e-08 33.9 6.7 0.016 14.8 0.1 4.7 2 1 2 4 4 4 2 CLASP N terminal Ank_2 PF12796.7 ETO02890.1 - 2.6e-07 31.1 0.2 2.2e-06 28.2 0.2 2.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) HEAT_EZ PF13513.6 ETO02890.1 - 2.6e-07 31.0 0.0 0.29 11.7 0.0 5.9 6 1 0 6 6 5 1 HEAT-like repeat Ank_3 PF13606.6 ETO02890.1 - 1e-06 28.6 0.1 0.0017 18.7 0.1 3.5 2 0 0 2 2 2 1 Ankyrin repeat RTP1_C1 PF10363.9 ETO02890.1 - 9.9e-06 25.7 10.8 1.9 8.7 0.1 6.7 3 2 3 7 7 7 2 Required for nuclear transport of RNA pol II C-terminus 1 Ank_5 PF13857.6 ETO02890.1 - 1.9e-05 24.9 0.0 5.7e-05 23.3 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO02890.1 - 5e-05 23.8 0.2 0.00033 21.1 0.2 2.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) MMS19_N PF14500.6 ETO02890.1 - 0.00099 18.8 6.0 0.038 13.6 0.1 4.1 3 1 1 4 4 4 1 Dos2-interacting transcription regulator of RNA-Pol-II Ank PF00023.30 ETO02890.1 - 0.0032 17.9 0.2 0.03 14.8 0.0 2.9 3 0 0 3 3 1 1 Ankyrin repeat NLRC4_HD2 PF17776.1 ETO02890.1 - 0.0086 16.6 1.1 0.23 12.0 0.0 4.0 2 0 0 2 2 2 1 NLRC4 helical domain HD2 Vac14_Fab1_bd PF12755.7 ETO02890.1 - 0.017 15.7 7.5 7.7 7.2 0.3 6.0 3 3 4 7 7 7 0 Vacuolar 14 Fab1-binding region Spore_Cse60 PF10957.8 ETO02890.1 - 0.11 12.5 8.4 21 5.2 0.1 4.8 4 0 0 4 4 4 0 Sporulation protein Cse60 DUF4485 PF14846.6 ETO02890.1 - 0.13 12.4 1.0 32 4.7 0.0 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4485) Dala_Dala_lig_N PF01820.21 ETO02890.1 - 0.15 12.5 0.0 0.88 10.1 0.0 2.5 1 1 0 1 1 1 0 D-ala D-ala ligase N-terminus NLE PF08154.12 ETO02890.1 - 0.16 12.5 1.1 38 4.9 0.1 3.9 3 0 0 3 3 3 0 NLE (NUC135) domain EF-hand_7 PF13499.6 ETO02890.1 - 0.18 12.3 5.2 10 6.7 0.0 5.3 5 1 1 6 6 5 0 EF-hand domain pair TPR_19 PF14559.6 ETO02890.1 - 0.49 10.9 2.1 5.6 7.6 0.1 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat Mlp PF03304.13 ETO02891.1 - 0.0026 18.0 5.1 0.0044 17.3 5.1 1.4 1 0 0 1 1 1 1 Mlp lipoprotein family MA3 PF02847.17 ETO02891.1 - 0.017 15.1 2.2 1 9.4 0.1 2.3 2 0 0 2 2 2 0 MA3 domain PUB PF09409.10 ETO02891.1 - 1.4 8.9 4.9 0.59 10.1 1.1 2.4 2 2 0 2 2 2 0 PUB domain Draxin PF15550.6 ETO02892.1 - 0.034 14.0 1.5 0.04 13.8 1.5 1.0 1 0 0 1 1 1 0 Draxin TINF2_N PF14973.6 ETO02892.1 - 0.3 11.4 3.5 0.28 11.5 1.2 1.8 1 1 1 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus zf-TRAF PF02176.18 ETO02895.1 - 8.2e-08 32.8 2.3 8.2e-08 32.8 2.3 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger Lge1 PF11488.8 ETO02897.1 - 0.18 12.0 0.3 0.18 12.0 0.3 1.7 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 HSBP1 PF06825.12 ETO02898.1 - 0.0012 18.6 5.6 0.0012 18.6 5.6 3.0 4 0 0 4 4 4 1 Heat shock factor binding protein 1 LMBR1 PF04791.16 ETO02898.1 - 0.02 13.9 14.5 0.025 13.5 14.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Pho88 PF10032.9 ETO02898.1 - 0.046 13.0 1.4 0.087 12.1 1.4 1.4 1 0 0 1 1 1 0 Phosphate transport (Pho88) DUF4062 PF13271.6 ETO02898.1 - 0.2 12.0 1.2 0.75 10.2 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4062) RmuC PF02646.16 ETO02898.1 - 0.57 9.3 14.0 0.44 9.6 3.9 2.4 2 0 0 2 2 2 0 RmuC family 4HB_MCP_1 PF12729.7 ETO02898.1 - 0.73 9.3 19.7 0.43 10.1 4.4 3.2 1 1 1 3 3 3 0 Four helix bundle sensory module for signal transduction Fzo_mitofusin PF04799.13 ETO02898.1 - 3.3 7.3 17.1 0.081 12.5 5.3 2.6 1 1 1 3 3 3 0 fzo-like conserved region DUF1664 PF07889.12 ETO02898.1 - 4.1 7.5 15.4 0.94 9.5 6.4 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Tweety PF04906.13 ETO02898.1 - 5.7 5.5 11.8 2.1 6.9 4.9 2.2 1 1 2 3 3 3 0 Tweety KxDL PF10241.9 ETO02901.1 - 0.029 14.7 3.4 0.061 13.6 3.4 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein Sas6_CC PF18594.1 ETO02901.1 - 0.36 10.7 2.2 1.1 9.0 0.3 2.3 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain NOA36 PF06524.12 ETO02901.1 - 0.68 9.2 20.6 0.99 8.7 20.6 1.3 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ETO02901.1 - 2.1 8.0 14.3 6.1 6.5 14.2 1.8 1 1 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ETO02901.1 - 5.8 5.1 16.9 6.5 4.9 16.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO02901.1 - 7 5.8 6.5 7.4 5.7 6.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ESM4 PF15952.5 ETO02903.1 - 6.7 7.1 9.5 11 6.4 9.5 1.3 1 0 0 1 1 1 0 Enhancer of split M4 family ORF6C PF10552.9 ETO02904.1 - 0.0014 18.7 2.1 0.0017 18.4 0.3 2.1 3 0 0 3 3 3 1 ORF6C domain NusA_N PF08529.11 ETO02904.1 - 0.03 14.7 0.2 0.049 14.0 0.2 1.3 1 0 0 1 1 1 0 NusA N-terminal domain DUF2491 PF10679.9 ETO02904.1 - 0.1 11.8 0.5 0.13 11.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2491) UCH PF00443.29 ETO02906.1 - 3.5e-20 72.6 0.0 5.2e-20 72.0 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO02906.1 - 1.7e-12 47.6 0.0 2.2e-08 34.1 0.0 2.1 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase DUF4407 PF14362.6 ETO02907.1 - 0.0088 15.4 4.9 0.59 9.4 0.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4407) SAPIS-gp6 PF16722.5 ETO02907.1 - 0.028 14.8 1.3 0.14 12.6 0.1 2.8 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus SCIMP PF15050.6 ETO02907.1 - 0.07 13.6 0.5 0.07 13.6 0.5 3.2 4 0 0 4 4 4 0 SCIMP protein MS_channel PF00924.18 ETO02907.1 - 0.083 12.4 0.6 0.27 10.7 0.6 1.8 1 0 0 1 1 1 0 Mechanosensitive ion channel UPF0160 PF03690.13 ETO02907.1 - 1.8 8.1 10.4 0.32 10.6 0.4 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0160) Cep57_MT_bd PF06657.13 ETO02907.1 - 9.7 6.7 11.0 6 7.4 0.5 3.5 3 1 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 PTR2 PF00854.21 ETO02908.1 - 9.1e-25 87.3 1.6 1.4e-24 86.7 1.6 1.4 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 ETO02908.1 - 6.3e-06 25.3 12.5 0.016 14.1 11.7 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily Rod_cone_degen PF15201.6 ETO02908.1 - 0.0099 16.0 3.5 0.02 15.0 1.5 2.3 1 1 1 2 2 2 1 Progressive rod-cone degeneration LPD3 PF18798.1 ETO02908.1 - 0.1 12.9 0.2 0.16 12.3 0.2 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 3 CTP_transf_1 PF01148.20 ETO02909.1 - 4.3e-63 213.6 12.9 7.3e-63 212.8 12.9 1.3 1 0 0 1 1 1 1 Cytidylyltransferase family CBS PF00571.28 ETO02910.1 - 2.3e-23 82.4 0.3 2e-05 25.0 0.0 4.3 4 0 0 4 4 4 4 CBS domain PilJ PF13675.6 ETO02911.1 - 0.00065 19.7 0.8 0.12 12.4 0.2 2.9 1 1 1 2 2 2 2 Type IV pili methyl-accepting chemotaxis transducer N-term EppA_BapA PF07268.11 ETO02912.1 - 0.19 11.7 2.5 0.45 10.5 2.5 1.7 1 1 0 1 1 1 0 Exported protein precursor (EppA/BapA) DUF4652 PF15525.6 ETO02913.1 - 0.025 14.3 3.0 0.035 13.9 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4652) WD40 PF00400.32 ETO02914.1 - 2.6e-12 47.1 7.6 0.018 15.9 0.2 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02914.1 - 0.13 12.6 0.0 1.5 9.2 0.0 2.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO02915.1 - 1.6e-21 76.2 11.6 0.00025 21.8 0.2 6.0 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02915.1 - 5.7e-07 29.7 0.1 0.11 12.8 0.0 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO02915.1 - 0.019 13.9 0.1 7.3 5.4 0.0 2.8 1 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ETO02915.1 - 0.13 12.8 0.3 45 4.7 0.0 3.2 2 1 0 2 2 2 0 PQQ-like domain TPR_12 PF13424.6 ETO02917.1 - 2.2e-70 232.9 13.0 1.1e-19 70.4 0.8 6.8 1 1 5 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO02917.1 - 7.7e-52 171.9 0.5 1.4e-08 34.3 0.0 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO02917.1 - 7.1e-42 139.6 33.7 4.2e-08 32.7 0.7 8.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO02917.1 - 1e-37 125.4 10.8 2.4e-06 27.2 0.0 8.5 8 1 1 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02917.1 - 1.8e-32 108.8 23.6 0.00015 21.6 0.1 8.6 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02917.1 - 3.8e-30 101.6 40.2 2.4e-05 24.2 0.7 8.5 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02917.1 - 9.1e-11 41.3 35.0 0.0056 16.3 0.0 9.3 7 3 3 10 10 10 6 TPR repeat TPR_17 PF13431.6 ETO02917.1 - 7.9e-10 38.4 9.9 0.025 15.0 0.1 7.3 8 2 0 8 8 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02917.1 - 2e-09 37.5 0.0 1.9 9.5 0.0 6.6 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02917.1 - 2.8e-09 37.5 0.0 0.21 12.3 0.0 6.6 5 1 1 6 6 6 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO02917.1 - 6.3e-09 35.8 20.1 0.36 10.6 1.2 7.2 6 2 2 8 8 8 4 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO02917.1 - 2.8e-07 30.7 6.1 4.5 8.1 0.0 7.1 8 0 0 8 8 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO02917.1 - 2.2e-06 27.3 0.0 0.0008 18.9 0.0 1.9 1 1 1 2 2 2 1 MalT-like TPR region TPR_19 PF14559.6 ETO02917.1 - 4.6e-05 23.8 0.4 1.4 9.4 0.2 4.1 4 0 0 4 4 3 2 Tetratricopeptide repeat DUF627 PF04781.12 ETO02917.1 - 7.4e-05 22.7 6.1 0.016 15.2 0.0 4.1 4 1 0 4 4 4 1 Protein of unknown function (DUF627) TPR_3 PF07720.12 ETO02917.1 - 0.0014 18.6 19.8 0.037 14.0 1.6 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO02917.1 - 0.0014 18.1 17.8 8.7 6.0 0.0 8.0 8 2 2 10 10 10 0 Helix-turn-helix bacterial domain ANAPC3 PF12895.7 ETO02917.1 - 0.0015 18.7 12.3 0.13 12.5 3.4 4.9 3 1 4 7 7 7 1 Anaphase-promoting complex, cyclosome, subunit 3 Mob_Pre PF01076.19 ETO02917.1 - 0.019 14.8 0.2 0.019 14.8 0.2 3.9 2 1 3 5 5 5 0 Plasmid recombination enzyme HisG PF01634.18 ETO02917.1 - 0.02 14.9 0.3 1.6 8.6 0.0 3.1 2 1 2 4 4 3 0 ATP phosphoribosyltransferase SHNi-TPR PF10516.9 ETO02917.1 - 0.024 14.1 12.2 14 5.3 0.1 7.0 8 0 0 8 8 8 0 SHNi-TPR NRBF2_MIT PF17169.4 ETO02917.1 - 0.14 12.4 5.1 4.9 7.4 0.1 4.4 2 1 2 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 Fis1_TPR_C PF14853.6 ETO02917.1 - 0.15 12.1 17.3 7.5 6.7 0.1 6.3 7 0 0 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 ETO02917.1 - 0.23 11.6 26.2 0.16 12.1 0.9 6.9 6 1 0 7 7 7 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 ETO02917.1 - 0.26 12.0 12.5 15 6.4 0.1 6.1 6 1 0 6 6 5 0 Sel1 repeat PPR PF01535.20 ETO02917.1 - 0.45 10.9 11.5 9.6 6.7 0.2 6.3 7 0 0 7 7 6 0 PPR repeat Phage_Treg PF04761.12 ETO02917.1 - 0.54 10.4 13.1 5.7 7.1 0.0 5.5 7 0 0 7 7 7 0 Lactococcus bacteriophage putative transcription regulator DUF4810 PF16068.5 ETO02917.1 - 1.8 9.2 12.4 2.4 8.8 0.6 4.9 6 2 0 6 6 4 0 Domain of unknown function (DUF4810) SLT PF01464.20 ETO02917.1 - 7 6.3 7.2 21 4.8 0.6 3.2 3 0 0 3 3 3 0 Transglycosylase SLT domain Gly-zipper_Omp PF13488.6 ETO02918.1 - 9.2e-18 64.0 44.1 9.5e-05 22.3 7.6 5.7 1 1 3 4 4 4 4 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO02918.1 - 4.4e-12 45.5 18.3 0.0062 16.2 0.1 5.2 1 1 2 3 3 3 3 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 ETO02918.1 - 0.0037 17.1 41.7 0.23 11.4 4.0 6.6 1 1 3 4 4 4 3 Glycine zipper 2TM domain DUF456 PF04306.13 ETO02918.1 - 0.039 14.3 65.2 0.46 10.8 11.6 5.2 1 1 3 4 4 4 0 Protein of unknown function (DUF456) Gly-zipper_OmpA PF13436.6 ETO02918.1 - 0.15 11.9 31.6 4.3 7.2 0.9 5.3 1 1 2 3 3 3 0 Glycine-zipper domain TM_helix PF05552.12 ETO02918.1 - 0.37 10.8 21.0 32 4.6 0.1 5.5 2 1 1 3 3 3 0 Conserved TM helix TraT PF05818.12 ETO02918.1 - 1.4 8.5 17.3 0.84 9.3 2.0 3.3 1 1 2 3 3 3 0 Enterobacterial TraT complement resistance protein Transgly_assoc PF04226.13 ETO02918.1 - 8.2 6.8 57.8 2.2 8.6 12.1 5.8 1 1 3 4 4 4 0 Transglycosylase associated protein Glycogen_syn PF05693.13 ETO02919.1 - 0.015 13.9 0.1 0.015 13.9 0.1 1.1 1 0 0 1 1 1 0 Glycogen synthase COQ7 PF03232.13 ETO02919.1 - 0.061 13.1 0.3 0.12 12.1 0.3 1.4 1 0 0 1 1 1 0 Ubiquinone biosynthesis protein COQ7 Ank_3 PF13606.6 ETO02920.1 - 0.0067 16.8 0.3 12 6.8 0.0 3.8 3 1 1 4 4 4 2 Ankyrin repeat WD40 PF00400.32 ETO02921.1 - 9.5e-17 61.1 13.3 2.8e-06 27.9 0.6 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO02921.1 - 1.1e-05 25.6 0.1 0.048 14.0 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO02921.1 - 0.0024 16.6 3.2 0.015 14.0 1.8 2.1 1 1 0 2 2 2 1 Nucleoporin Nup120/160 HEAT PF02985.22 ETO02922.1 - 1.4e-11 43.6 0.0 0.18 12.2 0.0 7.0 7 0 0 7 7 7 3 HEAT repeat HEAT_EZ PF13513.6 ETO02922.1 - 3.1e-07 30.8 0.0 2.1 9.0 0.0 6.3 6 0 0 6 6 6 2 HEAT-like repeat HEAT_2 PF13646.6 ETO02922.1 - 4e-07 30.3 0.0 0.18 12.2 0.0 5.4 4 2 1 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ETO02922.1 - 7.7e-05 22.8 18.6 0.23 11.5 0.2 5.3 1 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 EH_Signature PF15611.6 ETO02922.1 - 0.0032 17.0 0.2 0.0061 16.0 0.2 1.5 1 0 0 1 1 1 1 EH_Signature domain Imm70 PF15601.6 ETO02922.1 - 0.0034 16.9 0.5 11 5.6 0.0 4.9 5 1 1 6 6 6 1 Immunity protein 70 VPS28 PF03997.12 ETO02922.1 - 0.0042 16.8 1.0 0.016 14.9 0.2 2.3 1 1 0 1 1 1 1 VPS28 protein Tudor_RapA PF18337.1 ETO02922.1 - 0.15 12.3 0.1 2.4 8.4 0.0 2.6 2 0 0 2 2 2 0 RapA N-terminal Tudor like domain DUF2431 PF10354.9 ETO02923.1 - 8e-11 42.5 13.7 3.5e-07 30.6 0.0 3.9 3 1 1 4 4 4 2 Domain of unknown function (DUF2431) La PF05383.17 ETO02924.1 - 0.015 15.3 2.0 0.023 14.8 2.0 1.3 1 0 0 1 1 1 0 La domain HEPPP_synt_1 PF07307.11 ETO02924.1 - 0.35 10.5 7.9 0.51 9.9 7.9 1.3 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 DUF3807 PF12720.7 ETO02924.1 - 1.1 9.5 15.3 1.2 9.3 15.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Hydin_ADK PF17213.3 ETO02924.1 - 1.2 9.4 6.3 1.3 9.3 6.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF2828 PF11443.8 ETO02924.1 - 1.4 6.9 13.9 1.5 6.9 13.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Connexin PF00029.19 ETO02924.1 - 2 8.1 10.8 2.1 8.1 10.8 1.2 1 0 0 1 1 1 0 Connexin DUF3405 PF11885.8 ETO02924.1 - 2.9 6.4 16.7 3.1 6.3 16.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Presenilin PF01080.17 ETO02924.1 - 3.2 6.4 6.7 3.2 6.4 6.7 1.0 1 0 0 1 1 1 0 Presenilin GCD14 PF08704.10 ETO02924.1 - 3.6 7.2 8.7 4.2 7.0 8.7 1.1 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit EOS1 PF12326.8 ETO02924.1 - 3.8 7.4 7.5 4.2 7.3 7.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein Peptidase_S49_N PF08496.10 ETO02924.1 - 5.2 7.1 21.3 7.1 6.7 21.3 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3464 PF11947.8 ETO02924.1 - 5.5 6.7 12.4 7.2 6.3 12.4 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF3506 PF12014.8 ETO02924.1 - 6.4 6.8 7.8 12 5.9 7.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3506) DUF4569 PF15133.6 ETO02924.1 - 9.9 5.8 12.0 11 5.6 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Kelch_6 PF13964.6 ETO02925.1 - 0.00067 19.9 0.5 1.8 9.0 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO02925.1 - 0.024 14.6 0.8 0.18 11.8 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO02925.1 - 0.059 13.0 0.6 11 5.7 0.0 3.5 3 0 0 3 3 3 0 Kelch motif PUB PF09409.10 ETO02926.1 - 0.035 14.0 0.4 0.18 11.8 0.4 2.2 1 1 0 1 1 1 0 PUB domain DUF5115 PF17142.4 ETO02926.1 - 0.098 12.3 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5115) ERAP1_C PF11838.8 ETO02927.1 - 1.6e-19 70.6 0.1 1.8e-19 70.5 0.1 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain Cas6b_C PF17262.2 ETO02927.1 - 0.13 12.4 0.0 0.42 10.7 0.0 1.8 2 0 0 2 2 2 0 Cas6b C-terminal domain PIP49_N PF14875.6 ETO02929.1 - 0.2 11.5 3.7 0.18 11.6 0.7 1.9 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 DnaJ PF00226.31 ETO02931.1 - 1.1e-22 80.0 1.2 1.1e-22 80.0 1.2 2.0 2 0 0 2 2 2 1 DnaJ domain DnaJ_C PF01556.18 ETO02931.1 - 3.9e-13 49.7 0.1 7.3e-13 48.9 0.1 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO02931.1 - 0.0013 19.0 17.2 0.014 15.8 12.9 2.5 2 0 0 2 2 2 2 DnaJ central domain Mrr_cat PF04471.12 ETO02933.1 - 0.1 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Restriction endonuclease LMBR1 PF04791.16 ETO02934.1 - 0.0026 16.8 6.1 0.0031 16.5 6.1 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF1676 PF07898.13 ETO02934.1 - 0.52 10.3 5.0 1.6 8.8 5.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) Menin PF05053.13 ETO02934.1 - 2.2 6.6 13.7 3 6.1 13.7 1.2 1 0 0 1 1 1 0 Menin HEAT PF02985.22 ETO02935.1 - 4.5e-05 23.3 0.0 0.041 14.1 0.0 3.1 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ETO02935.1 - 0.00011 22.5 0.0 0.00022 21.5 0.0 1.5 1 0 0 1 1 1 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO02935.1 - 0.00015 22.3 0.1 0.00054 20.5 0.0 2.0 1 1 0 1 1 1 1 Vacuolar 14 Fab1-binding region NLE PF08154.12 ETO02935.1 - 0.00063 20.2 2.6 0.94 10.1 0.1 3.4 2 1 1 4 4 4 2 NLE (NUC135) domain HEAT_PBS PF03130.16 ETO02935.1 - 0.016 15.8 0.0 4.9 8.1 0.0 2.7 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat HEAT_EZ PF13513.6 ETO02935.1 - 0.018 15.6 0.0 0.052 14.1 0.0 1.9 2 0 0 2 2 2 0 HEAT-like repeat Spore_Cse60 PF10957.8 ETO02935.1 - 0.062 13.3 2.5 4.6 7.3 0.0 3.3 3 0 0 3 3 3 0 Sporulation protein Cse60 RTP1_C1 PF10363.9 ETO02935.1 - 0.076 13.2 3.5 1.1 9.5 0.0 3.0 2 1 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Nsp1_C PF05064.13 ETO02935.1 - 0.52 10.1 2.9 6.3 6.6 0.1 3.0 2 2 0 2 2 2 0 Nsp1-like C-terminal region Syntaphilin PF15290.6 ETO02935.1 - 1.5 8.4 4.0 13 5.3 0.0 2.7 2 2 1 3 3 3 0 Golgi-localised syntaxin-1-binding clamp Transferase PF02458.15 ETO02938.1 - 0.01 14.5 0.0 0.014 14.1 0.0 1.2 1 0 0 1 1 1 0 Transferase family GILT PF03227.16 ETO02941.1 - 3.6e-07 30.4 0.4 1.2e-06 28.7 0.0 2.0 2 0 0 2 2 2 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Ank_3 PF13606.6 ETO02942.1 - 1.9e-06 27.8 0.9 0.00029 21.1 0.1 3.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO02942.1 - 5.7e-06 26.5 0.7 2.2e-05 24.7 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO02942.1 - 1.1e-05 25.9 0.2 3.2e-05 24.4 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO02942.1 - 0.0012 19.4 0.6 0.0087 16.6 0.5 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO02942.1 - 0.0051 17.2 0.0 0.017 15.5 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeat Sacchrp_dh_NADP PF03435.18 ETO02942.1 - 0.012 15.8 0.1 0.039 14.2 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain WD40 PF00400.32 ETO02943.1 - 8.7e-15 54.9 3.2 2.7e-06 28.0 0.6 3.0 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO02943.1 - 0.00032 19.5 0.1 0.079 11.6 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02943.1 - 0.0013 19.0 0.1 1.1 9.6 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO02943.1 - 0.034 14.2 0.4 9.3 6.3 0.1 2.6 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region PIG-F PF06699.11 ETO02945.1 - 0.013 15.7 0.0 0.014 15.6 0.0 1.1 1 0 0 1 1 1 0 GPI biosynthesis protein family Pig-F Fumarate_red_D PF02313.17 ETO02945.1 - 0.019 15.1 0.2 0.023 14.8 0.2 1.1 1 0 0 1 1 1 0 Fumarate reductase subunit D DUF3481 PF11980.8 ETO02945.1 - 0.083 12.6 0.2 0.11 12.2 0.2 1.3 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein GIT_CC PF16559.5 ETO02947.1 - 0.0075 16.1 0.4 0.015 15.2 0.4 1.5 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 ETO02947.1 - 0.0093 16.6 1.1 0.0093 16.6 1.1 2.0 2 0 0 2 2 2 1 Initiation control protein YabA TSC22 PF01166.18 ETO02947.1 - 0.29 11.5 4.4 0.17 12.2 1.9 1.9 2 0 0 2 2 2 0 TSC-22/dip/bun family TolA_bind_tri PF16331.5 ETO02947.1 - 0.3 11.2 5.4 0.88 9.7 0.9 2.1 2 0 0 2 2 2 0 TolA binding protein trimerisation Peptidase_C14 PF00656.22 ETO02948.1 - 2.4e-10 40.8 2.3 2.4e-10 40.8 0.2 2.1 2 0 0 2 2 2 1 Caspase domain DUF3646 PF12362.8 ETO02948.1 - 0.011 16.1 2.8 0.024 15.0 2.8 1.5 1 0 0 1 1 1 0 DNA polymerase III gamma and tau subunits C terminal CDC45 PF02724.14 ETO02948.1 - 0.013 13.9 9.5 0.017 13.5 9.5 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4611 PF15387.6 ETO02948.1 - 0.047 13.9 9.5 0.17 12.2 9.5 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) YL1 PF05764.13 ETO02948.1 - 0.34 11.0 21.8 0.7 10.0 21.6 1.5 1 1 0 1 1 1 0 YL1 nuclear protein MDM10 PF12519.8 ETO02948.1 - 0.56 9.0 10.7 0.82 8.5 10.7 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DDHD PF02862.17 ETO02948.1 - 1.1 9.4 6.0 1.3 9.2 2.5 2.2 2 0 0 2 2 2 0 DDHD domain RNase_H2_suC PF08615.11 ETO02948.1 - 2.8 8.1 6.8 1.1 9.4 3.9 1.9 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) CAC1F_C PF16885.5 ETO02948.1 - 3.4 7.2 10.1 5.2 6.6 10.1 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term NOA36 PF06524.12 ETO02948.1 - 4.6 6.5 13.4 8.6 5.6 13.4 1.4 1 0 0 1 1 1 0 NOA36 protein UPF0160 PF03690.13 ETO02949.1 - 3.6e-31 109.0 0.0 3.8e-31 108.9 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) DUF4402 PF14352.6 ETO02951.1 - 0.1 13.3 0.0 0.19 12.3 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4402) Microtub_bind PF13931.6 ETO02951.1 - 0.12 12.8 2.1 0.16 12.4 2.1 1.2 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding Bunya_G2 PF03563.13 ETO02951.1 - 0.12 11.6 0.3 0.14 11.4 0.3 1.1 1 0 0 1 1 1 0 Bunyavirus glycoprotein G2 zf-C3HC4_2 PF13923.6 ETO02952.1 - 0.64 9.9 4.4 9.4 6.2 4.4 2.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) CLPTM1 PF05602.12 ETO02955.1 - 0.066 12.2 0.4 0.1 11.6 0.3 1.3 1 1 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) S6PP_C PF08472.10 ETO02957.1 - 0.083 12.8 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Sucrose-6-phosphate phosphohydrolase C-terminal NOA36 PF06524.12 ETO02958.1 - 0.24 10.7 19.0 0.35 10.2 19.0 1.3 1 0 0 1 1 1 0 NOA36 protein DUF913 PF06025.12 ETO02958.1 - 1.5 7.7 5.0 1.3 7.9 5.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DARPP-32 PF05395.12 ETO02958.1 - 2 8.6 17.7 0.035 14.3 10.8 1.7 2 1 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 rve PF00665.26 ETO02959.1 - 7.5e-08 32.6 0.0 1.1e-07 32.1 0.0 1.2 1 0 0 1 1 1 1 Integrase core domain Integrase_H2C2 PF17921.1 ETO02959.1 - 0.00069 19.7 0.5 0.0069 16.5 0.5 2.2 1 1 0 1 1 1 1 Integrase zinc binding domain Tubulin_C PF03953.17 ETO02960.1 - 0.066 13.4 0.1 0.094 12.9 0.1 1.2 1 0 0 1 1 1 0 Tubulin C-terminal domain Kelch_4 PF13418.6 ETO02961.1 - 2.6e-07 30.5 0.2 0.0035 17.3 0.1 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO02961.1 - 3.6e-07 29.7 2.5 0.0014 18.2 0.6 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO02961.1 - 0.00052 19.9 9.9 0.25 11.4 1.8 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO02961.1 - 0.00085 19.2 2.5 0.044 13.8 0.3 3.4 3 1 0 3 3 3 1 Kelch motif Glyoxal_oxid_N PF07250.11 ETO02961.1 - 0.0012 18.1 0.2 0.0033 16.7 0.0 1.7 1 1 1 2 2 2 1 Glyoxal oxidase N-terminus Kelch_6 PF13964.6 ETO02961.1 - 0.0013 18.9 1.2 2.3 8.6 0.7 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO02961.1 - 0.0088 16.3 0.4 2.1 8.7 0.1 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain UPF0180 PF03698.13 ETO02961.1 - 0.097 12.9 0.3 4.6 7.5 0.0 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0180) DUF1744 PF08490.12 ETO02962.1 - 2.7e-25 88.8 2.0 3e-25 88.7 2.0 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) DNA_pol_B PF00136.21 ETO02962.1 - 0.036 12.8 0.0 0.036 12.8 0.0 1.0 1 0 0 1 1 1 0 DNA polymerase family B DUF1744 PF08490.12 ETO02963.1 - 8.5e-34 116.8 0.2 1e-33 116.5 0.2 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) WD40 PF00400.32 ETO02965.1 - 1.2e-15 57.6 12.0 1.4e-06 28.9 2.3 3.9 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO02965.1 - 4.7e-05 22.2 2.6 0.014 14.1 0.1 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO02965.1 - 0.0012 19.1 0.0 2.6 8.4 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Actin_micro PF17003.5 ETO02965.1 - 0.0029 16.9 0.4 0.0039 16.4 0.4 1.2 1 0 0 1 1 1 1 Putative actin-like family DUF4221 PF13970.6 ETO02965.1 - 0.011 15.3 1.0 0.016 14.8 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) NigD_C PF17415.2 ETO02966.1 - 0.2 11.8 3.7 0.29 11.2 0.9 2.2 2 0 0 2 2 2 0 NigD-like C-terminal beta sandwich domain SopA PF13981.6 ETO02968.1 - 0.062 13.7 1.7 0.22 11.9 0.1 2.2 2 1 0 2 2 2 0 SopA-like central domain UCH PF00443.29 ETO02969.1 - 9e-21 74.5 2.5 1.2e-20 74.2 2.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO02969.1 - 0.003 17.2 0.1 0.0032 17.1 0.1 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase RVT_1 PF00078.27 ETO02971.1 - 1.7e-13 50.6 9.4 5.7e-10 39.1 0.4 2.9 2 1 1 3 3 3 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF16 PF01519.16 ETO02971.1 - 0.015 15.7 6.1 1.3 9.5 1.7 2.8 2 0 0 2 2 2 0 Protein of unknown function DUF16 TPR_1 PF00515.28 ETO02972.1 - 3.9e-12 45.4 4.6 7.2e-06 25.6 0.2 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO02972.1 - 5e-10 38.8 3.0 4.9e-05 23.2 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO02972.1 - 2.3e-08 34.5 0.0 7.4e-08 32.9 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO02972.1 - 8.4e-08 31.8 8.8 0.00048 20.0 0.6 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO02972.1 - 1.6e-07 31.6 0.3 0.019 15.7 0.0 3.3 2 1 1 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO02972.1 - 3.8e-07 29.7 4.0 3e-05 23.6 0.8 2.6 1 1 1 2 2 2 2 TPR repeat TPR_17 PF13431.6 ETO02972.1 - 1.6e-06 28.1 3.4 0.00088 19.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO02972.1 - 0.00054 20.4 0.3 0.0014 19.0 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO02972.1 - 0.0033 17.7 2.1 0.093 13.0 2.1 2.5 1 1 0 1 1 1 1 Tetratricopeptide repeat KxDL PF10241.9 ETO02972.1 - 0.039 14.2 0.7 0.039 14.2 0.7 2.2 3 0 0 3 3 3 0 Uncharacterized conserved protein TPR_10 PF13374.6 ETO02972.1 - 0.067 13.1 4.7 0.88 9.5 0.1 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ETO02972.1 - 0.31 11.5 2.6 1.3 9.5 0.1 2.6 3 1 0 3 3 3 0 Alkyl sulfatase dimerisation UPF0182 PF03699.13 ETO02974.1 - 0.02 13.0 10.1 0.023 12.8 10.1 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) MscS_TM PF12794.7 ETO02976.1 - 2 7.2 3.6 2.1 7.2 2.8 1.4 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF1506 PF07405.11 ETO02977.1 - 0.009 16.2 1.1 0.024 14.8 0.7 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1506) Kelch_1 PF01344.25 ETO02977.1 - 0.058 13.0 0.5 2.5 7.8 0.2 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO02977.1 - 0.089 12.8 3.0 5.8 7.0 0.2 3.9 4 0 0 4 4 4 0 Kelch motif Senescence PF06911.12 ETO02979.1 - 3.2e-05 24.3 0.2 3.9e-05 24.0 0.2 1.1 1 0 0 1 1 1 1 Senescence-associated protein Ku_C PF03730.14 ETO02982.1 - 0.13 13.0 3.3 0.15 12.8 0.5 2.4 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm Mis12 PF05859.12 ETO02983.1 - 0.26 11.3 2.9 0.28 11.2 0.5 2.3 3 0 0 3 3 3 0 Mis12 protein zf-CCHC_3 PF13917.6 ETO02985.1 - 0.0013 18.7 0.6 0.0035 17.3 0.6 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ETO02985.1 - 0.0057 16.7 0.7 0.009 16.1 0.7 1.3 1 0 0 1 1 1 1 Zinc knuckle CALM_bind PF16025.5 ETO02985.1 - 0.096 13.2 0.6 0.096 13.2 0.6 3.0 3 1 0 3 3 3 0 Calcium-dependent calmodulin binding zf-CCHC_4 PF14392.6 ETO02985.1 - 0.11 12.3 1.7 0.14 11.9 0.4 1.8 2 0 0 2 2 2 0 Zinc knuckle Preseq_ALAS PF09029.10 ETO02985.1 - 0.25 11.8 3.4 0.62 10.6 3.4 1.7 1 1 0 1 1 1 0 5-aminolevulinate synthase presequence Memo PF01875.17 ETO02986.1 - 0.00068 18.9 0.0 0.00096 18.4 0.0 1.1 1 0 0 1 1 1 1 Memo-like protein Haem_oxygenas_2 PF14518.6 ETO02986.1 - 0.12 12.1 0.2 0.22 11.3 0.0 1.4 2 0 0 2 2 2 0 Iron-containing redox enzyme DNA_pol_phi PF04931.13 ETO02989.1 - 0.00097 17.4 2.7 0.0011 17.1 2.7 1.0 1 0 0 1 1 1 1 DNA polymerase phi CUE PF02845.16 ETO02989.1 - 0.021 14.5 0.1 0.046 13.4 0.1 1.6 1 0 0 1 1 1 0 CUE domain Orbi_VP4 PF05059.12 ETO02990.1 - 0.089 10.8 0.0 0.11 10.5 0.0 1.1 1 0 0 1 1 1 0 Orbivirus VP4 core protein NOG1 PF06858.14 ETO02990.1 - 0.24 11.2 0.2 0.24 11.2 0.2 2.1 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) bZIP_1 PF00170.21 ETO02992.1 - 2.6e-09 37.0 10.0 2.6e-09 37.0 10.0 2.5 2 0 0 2 2 2 1 bZIP transcription factor bZIP_2 PF07716.15 ETO02992.1 - 0.00046 20.2 13.1 0.00046 20.2 13.1 2.6 2 1 0 2 2 2 1 Basic region leucine zipper DUF5357 PF17310.2 ETO02992.1 - 0.0019 16.8 0.3 0.0033 16.0 0.3 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5357) bZIP_Maf PF03131.17 ETO02992.1 - 0.28 11.7 8.6 0.66 10.5 8.6 1.6 1 0 0 1 1 1 0 bZIP Maf transcription factor YBD PF17725.1 ETO02993.1 - 0.052 13.4 0.2 0.093 12.6 0.1 1.5 2 0 0 2 2 2 0 YAP binding domain HEAT_2 PF13646.6 ETO02993.1 - 0.13 12.7 0.0 0.2 12.0 0.0 1.3 1 0 0 1 1 1 0 HEAT repeats Kelch_6 PF13964.6 ETO02994.1 - 0.00044 20.4 0.3 0.012 15.9 0.0 2.1 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO02994.1 - 0.00049 20.1 0.1 0.052 13.6 0.0 2.1 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO02994.1 - 0.011 15.2 0.1 0.19 11.3 0.0 2.1 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO02994.1 - 0.12 12.4 0.0 7 6.7 0.0 2.2 2 0 0 2 2 2 0 Kelch motif MRP-L46 PF11788.8 ETO02996.1 - 1 10.1 8.6 0.19 12.5 3.8 1.9 1 1 1 2 2 2 0 39S mitochondrial ribosomal protein L46 DUF1664 PF07889.12 ETO02997.1 - 0.024 14.7 2.4 0.024 14.7 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) SKA1 PF07160.12 ETO02997.1 - 0.05 13.5 16.7 0.072 12.9 16.7 1.3 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 NIBRIN_BRCT_II PF16508.5 ETO02997.1 - 0.5 10.7 5.5 0.85 10.0 4.9 1.6 2 0 0 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein TCTP PF00838.17 ETO02997.1 - 1 9.7 14.0 14 6.0 12.0 2.1 1 1 1 2 2 2 0 Translationally controlled tumour protein NPV_P10 PF05531.12 ETO02997.1 - 1.7 9.2 12.8 0.099 13.1 4.1 2.4 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein zf-C2HE PF16278.5 ETO02997.1 - 1.9 9.0 11.1 0.28 11.7 1.9 2.6 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger MRP-S32 PF10210.9 ETO02997.1 - 3.4 8.3 9.3 23 5.6 9.3 2.1 1 1 0 1 1 1 0 Mitochondrial 28S ribosomal protein S32 PUB PF09409.10 ETO02998.1 - 0.011 15.6 0.7 0.067 13.1 0.7 2.2 1 1 0 1 1 1 0 PUB domain EF1G PF00647.19 ETO02998.1 - 0.024 14.7 0.3 0.024 14.7 0.3 2.0 2 0 0 2 2 2 0 Elongation factor 1 gamma, conserved domain CW_binding_1 PF01473.20 ETO02998.1 - 0.56 10.6 4.9 1.4 9.4 4.9 1.7 1 0 0 1 1 1 0 Putative cell wall binding repeat RPN2_C PF18004.1 ETO03000.1 - 4.1 7.3 13.5 0.47 10.4 6.1 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain WD40 PF00400.32 ETO03001.1 - 0.0003 21.5 5.3 0.00065 20.5 0.2 3.2 3 1 0 3 3 3 1 WD domain, G-beta repeat Glyco_hydro_30 PF02055.16 ETO03001.1 - 0.0091 15.0 0.0 0.0098 14.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain NLRC4_HD2 PF17776.1 ETO03002.1 - 0.037 14.6 0.1 0.073 13.6 0.1 1.6 1 0 0 1 1 1 0 NLRC4 helical domain HD2 NACHT PF05729.12 ETO03003.1 - 7.7e-09 35.7 0.0 3.4e-08 33.6 0.0 2.1 2 0 0 2 2 2 1 NACHT domain ATP_bind_2 PF03668.15 ETO03003.1 - 0.0056 16.0 0.1 0.72 9.1 0.0 2.6 2 0 0 2 2 2 1 P-loop ATPase protein family AAA_22 PF13401.6 ETO03003.1 - 0.0068 16.7 0.0 0.025 14.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO03003.1 - 0.0068 16.9 0.3 0.1 13.1 0.0 2.9 2 0 0 2 2 2 1 AAA domain TsaE PF02367.17 ETO03003.1 - 0.038 14.0 0.0 0.3 11.1 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETO03003.1 - 0.13 12.7 0.0 0.49 10.7 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 ETO03003.1 - 0.25 11.7 3.6 0.38 11.2 0.0 3.1 3 0 0 3 3 3 0 RNA helicase ATG101 PF07855.12 ETO03003.1 - 0.29 11.1 4.2 4.3 7.3 0.8 2.9 3 0 0 3 3 3 0 Autophagy-related protein 101 PALP PF00291.25 ETO03004.1 - 1.4e-64 218.4 0.0 1.6e-64 218.1 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme RNA_pol_Rpc34 PF05158.12 ETO03004.1 - 2.4 7.5 6.4 1.6 8.0 0.1 3.1 4 0 0 4 4 4 0 RNA polymerase Rpc34 subunit Gpi1 PF05024.15 ETO03007.1 - 0.0035 17.5 0.0 0.0049 17.0 0.0 1.2 1 0 0 1 1 1 1 N-acetylglucosaminyl transferase component (Gpi1) WD40 PF00400.32 ETO03009.1 - 8.1e-26 89.8 1.7 6.9e-08 33.0 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03009.1 - 1e-05 25.7 0.2 0.014 15.6 0.1 3.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03009.1 - 0.00011 21.3 0.1 0.072 12.0 0.0 2.3 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO03009.1 - 0.00015 21.2 0.7 0.0017 17.8 0.2 2.0 2 0 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO03009.1 - 0.00062 18.5 0.2 2.6 6.6 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO03009.1 - 0.036 12.8 5.5 0.98 8.1 0.6 2.7 1 1 0 2 2 2 0 Nup133 N terminal like DUF2963 PF11178.8 ETO03009.1 - 1.2 8.9 7.7 0.36 10.6 1.4 3.0 2 2 0 2 2 2 0 Protein of unknown function (DUF2963) HEAT_2 PF13646.6 ETO03010.1 - 0.00095 19.5 0.1 0.007 16.7 0.1 2.1 1 1 1 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO03010.1 - 0.0017 18.5 0.0 4 7.9 0.0 3.5 3 1 0 3 3 3 2 HEAT repeat TIP120 PF08623.10 ETO03010.1 - 0.0031 17.3 0.3 0.27 11.0 0.0 2.4 1 1 1 2 2 2 1 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 ETO03010.1 - 0.0041 17.6 0.0 0.051 14.1 0.0 2.3 2 0 0 2 2 2 1 HEAT-like repeat XkdW PF09636.10 ETO03010.1 - 0.01 15.9 0.1 0.23 11.6 0.0 2.4 1 1 1 2 2 2 0 XkdW protein DUF4795 PF16043.5 ETO03010.1 - 0.34 10.5 1.8 2.4 7.7 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) Spore_Cse60 PF10957.8 ETO03010.1 - 5.7 7.1 5.9 14 5.8 0.4 3.4 3 1 1 4 4 4 0 Sporulation protein Cse60 SCHIP-1 PF10148.9 ETO03011.1 - 0.00057 19.6 2.8 0.0007 19.3 2.8 1.0 1 0 0 1 1 1 1 Schwannomin-interacting protein 1 Presenilin PF01080.17 ETO03011.1 - 7.3 5.2 9.6 7.9 5.1 9.6 1.1 1 0 0 1 1 1 0 Presenilin Lyase_1 PF00206.20 ETO03012.1 - 3.8e-51 174.3 0.1 6.3e-51 173.6 0.0 1.4 2 0 0 2 2 2 1 Lyase ASL_C2 PF14698.6 ETO03012.1 - 0.024 15.4 0.0 0.076 13.8 0.0 1.9 1 0 0 1 1 1 0 Argininosuccinate lyase C-terminal DEP PF00610.21 ETO03012.1 - 0.12 12.5 0.1 0.42 10.7 0.0 2.0 2 0 0 2 2 2 0 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ATPase-cat_bd PF12156.8 ETO03014.1 - 0.18 12.6 4.0 0.11 13.3 0.7 2.4 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase Dynamin_N PF00350.23 ETO03015.1 - 0.21 11.7 0.0 0.21 11.7 0.0 4.1 5 0 0 5 5 5 0 Dynamin family NACHT_N PF17100.5 ETO03015.1 - 0.75 9.6 8.1 1.3 8.8 1.9 2.6 2 0 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase Kelch_6 PF13964.6 ETO03016.1 - 0.089 13.1 0.2 0.26 11.6 0.1 1.7 2 0 0 2 2 2 0 Kelch motif UCH PF00443.29 ETO03017.1 - 0.00043 19.9 2.6 0.00043 19.9 2.6 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Hva1_TUDOR PF11160.8 ETO03017.1 - 0.06 13.5 0.5 0.15 12.2 0.5 1.7 1 0 0 1 1 1 0 Hypervirulence associated proteins TUDOR domain HMA PF00403.26 ETO03018.1 - 0.024 15.1 0.1 0.078 13.4 0.1 1.9 1 1 0 1 1 1 0 Heavy-metal-associated domain DUF4304 PF14137.6 ETO03019.1 - 0.028 14.6 0.1 0.034 14.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4304) Chlam_PMP PF02415.17 ETO03020.1 - 0.0018 18.7 30.6 0.38 11.3 0.6 6.0 5 1 0 5 5 5 3 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF4528 PF15031.6 ETO03020.1 - 0.082 13.0 0.2 0.27 11.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4528) COX5A PF02284.16 ETO03021.1 - 0.001 19.0 0.2 0.0012 18.8 0.2 1.1 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Va Vps52 PF04129.12 ETO03021.1 - 0.0028 16.5 2.8 0.0028 16.5 2.8 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family DUF1664 PF07889.12 ETO03021.1 - 0.061 13.4 1.5 0.064 13.3 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Lamp PF01299.17 ETO03022.1 - 0.023 14.5 1.9 0.029 14.2 1.9 1.2 1 0 0 1 1 1 0 Lysosome-associated membrane glycoprotein (Lamp) PIEZO PF15917.5 ETO03023.1 - 0.14 11.6 9.0 0.17 11.3 9.0 1.0 1 0 0 1 1 1 0 Piezo DUF4337 PF14235.6 ETO03025.1 - 1.4 9.0 7.4 2.2 8.4 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DDHD PF02862.17 ETO03025.1 - 3 8.0 5.9 0.2 11.8 1.0 1.5 2 0 0 2 2 2 0 DDHD domain SR-25 PF10500.9 ETO03025.1 - 4.5 6.8 25.0 7.8 6.0 25.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GCD14 PF08704.10 ETO03025.1 - 8.9 5.9 8.3 14 5.3 8.3 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit HlyD_3 PF13437.6 ETO03026.1 - 0.019 15.7 0.6 0.17 12.6 0.4 2.0 1 1 1 2 2 2 0 HlyD family secretion protein PKcGMP_CC PF16808.5 ETO03026.1 - 0.5 10.3 12.6 0.23 11.3 5.7 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HlyD_3 PF13437.6 ETO03027.1 - 0.014 16.1 0.2 0.025 15.3 0.2 1.4 1 1 0 1 1 1 0 HlyD family secretion protein Metal_hydrol PF10118.9 ETO03027.1 - 0.074 12.8 1.1 0.081 12.6 1.1 1.0 1 0 0 1 1 1 0 Predicted metal-dependent hydrolase FGAR-AT_linker PF18072.1 ETO03027.1 - 0.11 13.0 1.9 0.93 10.1 0.3 2.5 2 1 0 2 2 2 0 Formylglycinamide ribonucleotide amidotransferase linker domain Alpha-amylase_N PF02903.14 ETO03027.1 - 0.2 11.8 4.2 0.31 11.2 4.2 1.5 1 1 0 1 1 1 0 Alpha amylase, N-terminal ig-like domain DUF4225 PF13988.6 ETO03027.1 - 0.31 10.6 3.8 0.27 10.8 2.3 1.7 1 1 0 2 2 2 0 Protein of unknown function (DUF4225) UPF0242 PF06785.11 ETO03027.1 - 1.7 8.7 14.3 2 8.5 14.3 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Peptidase_M22 PF00814.25 ETO03028.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Glycoprotease family MMS19_N PF14500.6 ETO03029.1 - 0.0019 17.8 0.6 0.0027 17.3 0.3 1.4 1 1 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT PF02985.22 ETO03029.1 - 0.0095 16.1 0.0 12 6.5 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat MMS19_C PF12460.8 ETO03029.1 - 0.022 13.9 1.8 0.029 13.5 1.7 1.3 1 1 0 1 1 1 0 RNAPII transcription regulator C-terminal DUF508 PF04370.12 ETO03029.1 - 0.044 13.5 0.5 0.067 12.9 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) EFhand_Ca_insen PF08726.10 ETO03030.1 - 0.027 14.6 0.1 1.8 8.8 0.0 2.6 2 0 0 2 2 2 0 Ca2+ insensitive EF hand DUF1493 PF07377.12 ETO03030.1 - 0.038 14.4 1.6 0.055 13.9 1.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1493) SRR1 PF07985.12 ETO03031.1 - 0.047 13.7 0.0 0.5 10.4 0.0 2.3 3 0 0 3 3 3 0 SRR1 Peptidase_M41 PF01434.18 ETO03033.1 - 0.054 13.3 5.9 0.074 12.9 5.9 1.2 1 0 0 1 1 1 0 Peptidase family M41 DUF3685 PF12452.8 ETO03033.1 - 0.94 9.2 10.2 1.3 8.7 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) DUF3683 PF12447.8 ETO03033.1 - 2.6 8.2 7.9 18 5.5 1.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3683) PSCyt3 PF07627.11 ETO03033.1 - 3 8.2 6.3 6 7.2 2.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) DUF1764 PF08576.10 ETO03034.1 - 0.14 13.1 9.2 0.17 12.8 9.2 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Topoisom_I_N PF02919.15 ETO03034.1 - 0.27 10.7 9.1 0.3 10.6 9.1 1.0 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Connexin PF00029.19 ETO03034.1 - 0.33 10.7 5.6 0.37 10.5 5.6 1.0 1 0 0 1 1 1 0 Connexin DUF3886 PF13025.6 ETO03034.1 - 0.65 10.2 21.3 0.93 9.7 21.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Hydin_ADK PF17213.3 ETO03034.1 - 0.76 10.0 6.0 0.75 10.0 6.0 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CLN3 PF02487.17 ETO03034.1 - 1.7 7.6 4.8 2 7.4 4.8 1.0 1 0 0 1 1 1 0 CLN3 protein DUF4446 PF14584.6 ETO03034.1 - 1.9 8.5 7.1 2.4 8.1 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Presenilin PF01080.17 ETO03034.1 - 2.1 7.0 6.3 2.2 7.0 6.3 1.0 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 ETO03034.1 - 3.5 7.7 13.4 5.2 7.1 13.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal WD40 PF00400.32 ETO03036.1 - 1.3e-07 32.1 3.9 5e-06 27.2 0.5 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat PhoLip_ATPase_C PF16212.5 ETO03038.1 - 3.7e-44 151.3 24.0 7.3e-25 88.2 1.9 2.1 2 0 0 2 2 2 2 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 ETO03038.1 - 0.0041 17.4 0.2 0.0064 16.8 0.2 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETO03038.1 - 0.014 15.2 0.1 0.026 14.2 0.1 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase Aminotran_5 PF00266.19 ETO03039.1 - 0.07 12.1 0.1 0.089 11.7 0.1 1.2 1 0 0 1 1 1 0 Aminotransferase class-V NCD1 PF04904.13 ETO03040.1 - 4.4e-06 26.6 0.0 7.5e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 NAB conserved region 1 (NCD1) DUF16 PF01519.16 ETO03040.1 - 0.028 14.9 3.5 0.062 13.8 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 SAM_2 PF07647.17 ETO03040.1 - 0.09 12.9 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) NACHT PF05729.12 ETO03041.1 - 1.2e-18 67.6 0.0 4.1e-18 65.9 0.0 1.8 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO03041.1 - 0.00042 19.6 1.4 0.0027 16.9 0.0 2.7 2 1 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 ETO03041.1 - 0.019 15.3 0.0 0.069 13.5 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain STI1 PF17830.1 ETO03041.1 - 0.069 13.1 1.1 1.1 9.2 0.0 3.3 3 0 0 3 3 3 0 STI1 domain SMC_N PF02463.19 ETO03041.1 - 0.088 12.2 0.0 0.088 12.2 0.0 3.0 3 2 1 4 4 4 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ETO03041.1 - 0.13 12.5 1.9 0.37 11.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain DUF908 PF06012.12 ETO03042.1 - 0.0012 18.4 0.0 0.0025 17.3 0.0 1.5 2 0 0 2 2 2 1 Domain of Unknown Function (DUF908) Tubulin PF00091.25 ETO03043.1 - 2.8e-64 216.9 0.0 3.1e-64 216.8 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Lipase_3 PF01764.25 ETO03043.1 - 0.0097 15.8 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Tubulin_2 PF13809.6 ETO03043.1 - 0.037 13.2 0.0 0.053 12.7 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Misat_Tub_SegII PF10644.9 ETO03043.1 - 0.11 12.8 0.0 0.26 11.6 0.0 1.7 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ETO03043.1 - 0.18 11.5 0.0 0.3 10.7 0.0 1.3 1 0 0 1 1 1 0 Tubulin domain Tubulin_C PF03953.17 ETO03044.1 - 2.1e-32 111.9 0.1 2.5e-32 111.7 0.1 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain TPR_12 PF13424.6 ETO03045.1 - 1e-116 381.4 66.1 5.6e-18 65.0 0.3 10.7 6 2 4 11 11 11 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03045.1 - 2.3e-100 324.7 126.6 3.8e-08 32.8 1.5 16.3 16 0 0 16 16 16 16 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03045.1 - 1.1e-86 282.7 51.7 2.4e-07 30.4 0.0 16.3 16 0 0 16 16 16 16 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03045.1 - 9.7e-84 268.9 97.4 1.3e-06 28.1 0.2 16.4 16 0 0 16 16 16 16 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03045.1 - 2.8e-66 214.8 49.5 0.00023 20.9 0.2 16.7 16 0 0 16 16 16 14 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03045.1 - 1.3e-63 205.9 108.7 2.4e-06 27.3 0.5 16.4 16 0 0 16 16 16 13 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03045.1 - 4.6e-39 129.8 0.0 0.067 14.1 0.0 16.0 13 3 3 16 16 16 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03045.1 - 6e-37 126.0 6.4 0.00076 20.1 0.0 12.6 5 4 7 12 12 12 10 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03045.1 - 8.2e-37 123.4 27.1 0.054 14.2 0.1 16.3 16 0 0 16 16 16 8 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03045.1 - 1.9e-35 120.2 108.2 0.00015 21.3 3.2 18.1 15 4 4 19 19 18 12 TPR repeat TPR_17 PF13431.6 ETO03045.1 - 5e-28 95.4 71.7 0.003 17.8 0.5 16.2 16 0 0 16 16 15 9 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO03045.1 - 2.6e-19 68.4 15.8 0.035 13.6 0.1 12.2 12 0 0 12 12 12 4 SHNi-TPR ANAPC3 PF12895.7 ETO03045.1 - 3.3e-13 49.7 61.7 0.0015 18.7 2.1 9.6 6 1 3 10 10 10 8 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.7 ETO03045.1 - 6.2e-13 49.0 11.4 0.043 14.1 0.0 8.5 8 2 2 10 10 7 3 Tetratrico peptide repeat TPR_19 PF14559.6 ETO03045.1 - 1.1e-12 48.3 31.2 0.038 14.5 0.0 11.3 7 5 8 15 15 15 5 Tetratricopeptide repeat MIT PF04212.18 ETO03045.1 - 1.5e-11 44.1 88.0 0.069 13.2 0.4 16.3 16 1 0 17 17 17 6 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETO03045.1 - 1.6e-10 40.9 2.9 0.019 14.4 0.0 5.0 2 1 3 6 6 5 4 MalT-like TPR region PPR PF01535.20 ETO03045.1 - 6.6e-08 32.3 25.0 0.11 12.8 0.1 11.6 13 0 0 13 13 12 2 PPR repeat RPN7 PF10602.9 ETO03045.1 - 7.9e-08 32.2 58.2 0.01 15.6 0.3 11.9 6 2 6 12 12 12 5 26S proteasome subunit RPN7 DUF2225 PF09986.9 ETO03045.1 - 2.2e-07 30.8 73.1 0.075 12.7 0.6 10.3 2 1 9 11 11 11 8 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETO03045.1 - 2.6e-07 30.6 91.8 0.28 11.0 0.9 14.5 8 2 8 16 16 16 6 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETO03045.1 - 2.7e-05 24.7 40.6 6.6 7.6 0.1 12.8 15 0 0 15 15 12 0 Sel1 repeat zf-TRAF PF02176.18 ETO03045.1 - 4.4e-05 24.1 1.2 4.4e-05 24.1 1.2 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger TPR_9 PF13371.6 ETO03045.1 - 0.00037 20.6 0.0 5.5 7.2 0.0 4.7 5 0 0 5 5 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 ETO03045.1 - 0.0028 17.7 19.8 3.7 7.6 0.3 6.8 4 2 2 7 7 7 2 Domain of Unknown Function (DUF3856) TPR_3 PF07720.12 ETO03045.1 - 0.0028 17.6 78.0 0.024 14.6 0.3 12.5 13 0 0 13 13 12 3 Tetratricopeptide repeat Filament PF00038.21 ETO03045.1 - 0.0043 16.7 41.4 0.048 13.2 3.3 3.3 2 1 1 3 3 3 2 Intermediate filament protein OEP PF02321.18 ETO03045.1 - 3.2 7.5 49.2 0.018 14.9 3.4 7.5 4 3 2 7 7 6 0 Outer membrane efflux protein Peptidase_C58 PF03543.14 ETO03045.1 - 3.6 7.2 10.1 11 5.6 10.1 1.8 1 0 0 1 1 1 0 Yersinia/Haemophilus virulence surface antigen PIG-P PF08510.12 ETO03045.1 - 7.1 6.6 6.8 19 5.2 0.6 4.4 5 0 0 5 5 5 0 PIG-P UVR PF02151.19 ETO03045.1 - 8.2 6.3 12.4 51 3.8 0.2 6.2 5 0 0 5 5 4 0 UvrB/uvrC motif WD40 PF00400.32 ETO03046.1 - 1.3e-30 104.9 6.3 2.2e-10 40.9 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03046.1 - 9.1e-09 35.5 0.2 0.019 15.3 0.0 3.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03046.1 - 3.2e-07 29.4 0.7 0.0098 14.6 0.1 2.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO03046.1 - 8.4e-07 29.1 0.1 1.1e-06 28.7 0.1 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO03046.1 - 4.9e-06 26.1 0.1 0.00087 18.7 0.0 2.1 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO03046.1 - 0.0024 16.9 0.0 0.063 12.2 0.0 2.2 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO03046.1 - 0.012 14.1 0.1 0.044 12.3 0.1 1.7 1 1 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO03046.1 - 0.031 14.2 0.5 5.5 7.1 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO03046.1 - 0.2 10.3 2.5 3.8 6.1 0.2 2.7 1 1 0 2 2 2 0 Nup133 N terminal like WD40 PF00400.32 ETO03048.1 - 1.3e-66 218.9 18.9 2.4e-12 47.1 0.1 6.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03048.1 - 1.7e-27 95.5 0.1 0.00016 21.9 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03048.1 - 1.2e-13 51.1 0.2 0.00013 21.4 0.0 3.7 2 1 2 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETO03048.1 - 7.3e-12 45.6 0.0 0.0015 18.5 0.0 2.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO03048.1 - 8.1e-12 44.7 0.1 0.22 10.4 0.0 5.0 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO03048.1 - 1.4e-08 34.4 3.5 5.9 7.0 0.0 5.5 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO03048.1 - 1.3e-07 30.7 1.1 0.1 11.2 0.0 5.1 1 1 4 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO03048.1 - 1.5e-07 30.3 1.5 0.0008 18.0 0.2 3.3 1 1 2 3 3 3 3 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO03048.1 - 1.3e-06 28.2 0.7 0.00011 21.8 0.6 2.7 1 1 0 1 1 1 1 PQQ-like domain Proteasome_A_N PF10584.9 ETO03048.1 - 1.8e-05 24.3 6.2 7.7 6.3 0.0 5.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Frtz PF11768.8 ETO03048.1 - 3.6e-05 22.3 0.0 0.065 11.5 0.0 3.2 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz BBS2_Mid PF14783.6 ETO03048.1 - 4.3e-05 23.5 1.6 17 5.5 0.0 5.6 2 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Gmad1 PF10647.9 ETO03048.1 - 0.00015 21.6 0.4 0.055 13.2 0.3 2.9 2 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain DUF5570 PF17731.1 ETO03048.1 - 0.00027 21.0 11.4 2.2 8.4 0.2 5.0 1 1 3 5 5 5 1 Family of unknown function (DUF5570) DPPIV_N PF00930.21 ETO03048.1 - 0.00078 18.3 0.6 15 4.2 0.0 4.6 1 1 4 5 5 5 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Reg_prop PF07494.11 ETO03048.1 - 0.0069 16.5 0.8 50 4.6 0.0 4.8 5 0 0 5 5 5 0 Two component regulator propeller DUF3509 PF12021.8 ETO03048.1 - 0.018 14.8 0.0 3.7 7.4 0.0 3.7 2 1 3 5 5 5 0 Protein of unknown function (DUF3509) RE_XamI PF09572.10 ETO03048.1 - 0.026 14.2 0.0 10 5.7 0.0 3.3 1 1 3 4 4 4 0 XamI restriction endonuclease PQQ PF01011.21 ETO03048.1 - 0.039 13.9 0.0 1.9e+02 2.2 0.0 4.9 6 0 0 6 6 6 0 PQQ enzyme repeat Me-amine-dh_H PF06433.11 ETO03048.1 - 0.045 12.6 0.0 0.78 8.5 0.0 2.6 1 1 1 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) GCV_T_C PF08669.11 ETO03048.1 - 0.053 13.4 0.4 10 6.1 0.1 3.1 3 0 0 3 3 3 0 Glycine cleavage T-protein C-terminal barrel domain PH_TFIIH PF08567.11 ETO03048.1 - 0.14 12.5 0.9 1.1e+02 3.2 0.0 4.1 4 1 1 5 5 5 0 TFIIH p62 subunit, N-terminal domain ASCH PF04266.14 ETO03048.1 - 0.21 12.2 0.1 21 5.7 0.0 3.5 3 1 1 4 4 4 0 ASCH domain Peptidase_S29 PF02907.15 ETO03048.1 - 0.92 9.2 3.7 11 5.7 0.1 3.3 1 1 0 2 2 2 0 Hepatitis C virus NS3 protease PKD PF00801.20 ETO03048.1 - 3 7.8 5.3 16 5.4 0.1 3.4 2 2 1 3 3 3 0 PKD domain Atypical_Card PF18461.1 ETO03049.1 - 0.035 14.3 0.7 0.24 11.6 0.4 2.5 2 0 0 2 2 2 0 Atypical caspase recruitment domain DUF5344 PF17279.2 ETO03049.1 - 1.2 9.8 7.5 3.9 8.1 0.1 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5344) Pox_A32 PF04665.12 ETO03050.1 - 7.6e-09 35.4 0.7 1.3e-08 34.6 0.7 1.4 1 0 0 1 1 1 1 Poxvirus A32 protein NACHT PF05729.12 ETO03050.1 - 0.0081 16.1 0.1 0.04 13.8 0.1 2.0 2 0 0 2 2 2 1 NACHT domain ATPase_2 PF01637.18 ETO03050.1 - 0.011 15.7 0.1 0.019 14.9 0.1 1.4 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 ETO03050.1 - 0.058 13.9 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO03050.1 - 0.059 12.7 0.0 0.22 10.8 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 ETO03050.1 - 0.098 13.0 0.2 0.36 11.2 0.2 2.1 1 1 0 1 1 1 0 RNA helicase Roc PF08477.13 ETO03050.1 - 0.11 12.7 0.0 0.23 11.7 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ETO03050.1 - 0.12 12.7 0.1 0.23 11.8 0.1 1.9 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETO03050.1 - 0.17 11.8 0.0 1 9.3 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ETO03050.1 - 0.18 12.2 0.0 0.45 10.9 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DUF5517 PF17639.2 ETO03051.1 - 0.0085 16.4 0.1 0.16 12.3 0.1 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5517) DUF3713 PF12506.8 ETO03051.1 - 0.052 13.8 2.8 1.1 9.6 2.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3713) ThiP_synth PF10120.9 ETO03052.1 - 0.19 11.3 0.0 0.34 10.5 0.0 1.3 1 0 0 1 1 1 0 Thiamine-phosphate synthase LUC7 PF03194.15 ETO03054.1 - 0.024 14.3 0.7 0.039 13.6 0.7 1.3 1 0 0 1 1 1 0 LUC7 N_terminus DUF2555 PF10742.9 ETO03056.1 - 0.0034 17.2 0.0 0.9 9.4 0.0 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2555) BP28CT PF08146.12 ETO03056.1 - 0.014 15.2 1.1 1.5 8.7 0.1 3.6 2 2 1 3 3 3 0 BP28CT (NUC211) domain HEAT PF02985.22 ETO03056.1 - 0.015 15.5 0.2 8.7 6.9 0.0 3.9 4 0 0 4 4 4 0 HEAT repeat DUF2543 PF10820.8 ETO03056.1 - 0.018 15.2 2.1 0.84 9.9 0.0 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF2543) TetR_C_13 PF16925.5 ETO03056.1 - 0.061 13.3 0.3 2.5 8.0 0.0 2.4 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain FPL PF09758.9 ETO03056.1 - 0.14 12.2 4.6 2.5 8.1 0.4 3.4 2 1 1 3 3 3 0 Uncharacterised conserved protein Cys_rich_FGFR PF00839.17 ETO03056.1 - 0.57 10.4 0.1 0.57 10.4 0.1 2.8 3 1 1 4 4 4 0 Cysteine rich repeat Pox_TAA1 PF03295.14 ETO03058.1 - 0.095 12.6 0.5 0.19 11.6 0.1 1.7 2 0 0 2 2 2 0 Poxvirus trans-activator protein A1 C-terminal Lipoprotein_Ltp PF07553.11 ETO03059.1 - 0.024 14.9 0.1 0.066 13.5 0.1 1.7 1 0 0 1 1 1 0 Host cell surface-exposed lipoprotein Nup54_57_C PF18570.1 ETO03061.1 - 0.21 11.2 0.2 0.21 11.2 0.2 2.3 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain AZUL PF16558.5 ETO03064.1 - 0.012 15.8 0.2 0.019 15.2 0.2 1.3 1 0 0 1 1 1 0 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A zn-ribbon_14 PF16503.5 ETO03064.1 - 0.14 11.7 0.9 0.34 10.4 0.9 1.6 1 0 0 1 1 1 0 Zinc-ribbon Helicase_C PF00271.31 ETO03065.1 - 2.6e-08 34.2 0.0 4.7e-08 33.3 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain TFIIB PF00382.19 ETO03065.1 - 0.067 13.2 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Presenilin PF01080.17 ETO03066.1 - 4.4 6.0 6.5 4.9 5.8 6.5 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO03066.1 - 5.4 6.1 5.8 6.3 5.9 5.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETO03067.1 - 2.8e-10 40.6 4.9 3.8e-05 24.4 0.0 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO03067.1 - 0.11 11.1 1.0 11 4.5 0.0 2.8 1 1 2 3 3 3 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO03068.1 - 1.7e-64 212.2 16.5 1.1e-10 41.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03068.1 - 1.8e-28 98.7 3.1 3.4e-05 24.1 0.0 6.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03068.1 - 1.4e-11 44.2 2.1 0.00023 20.6 0.0 4.6 1 1 2 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO03068.1 - 2.7e-09 36.5 0.2 0.01 14.8 0.0 4.8 2 2 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO03068.1 - 6.4e-06 25.1 5.2 3.8 6.0 0.3 5.1 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO03068.1 - 0.0053 15.3 0.2 1.4 7.4 0.0 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO03068.1 - 0.018 15.0 3.5 5 7.2 0.0 4.9 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO03068.1 - 0.03 14.4 1.2 20 5.3 0.0 4.1 2 2 3 5 5 5 0 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO03068.1 - 0.045 13.1 1.5 2.7 7.3 0.1 3.3 1 1 3 4 4 4 0 Neuroblastoma-amplified sequence, N terminal WD40 PF00400.32 ETO03069.1 - 1.8e-36 123.5 14.5 1.3e-09 38.5 0.2 6.5 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03069.1 - 4.9e-14 52.4 1.6 0.0008 19.7 0.0 5.2 2 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03069.1 - 2.2e-05 24.0 12.4 0.00019 20.9 6.2 3.6 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO03069.1 - 0.00017 21.4 5.0 4 7.5 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO03069.1 - 0.00021 20.1 1.5 0.13 10.9 0.0 3.8 2 1 1 4 4 4 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO03069.1 - 0.0087 14.6 0.6 0.68 8.4 0.0 2.3 1 1 0 2 2 2 2 Cytochrome D1 heme domain Arf PF00025.21 ETO03070.1 - 5.6e-75 250.6 0.1 6.6e-75 250.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO03070.1 - 1.2e-13 51.3 0.0 1.9e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO03070.1 - 1.6e-12 47.3 0.0 1.9e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ETO03070.1 - 2e-12 46.9 0.0 2.7e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ETO03070.1 - 5.4e-11 42.3 1.0 4.7e-08 32.6 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ETO03070.1 - 2.3e-08 33.7 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO03070.1 - 4.6e-05 23.5 0.2 9e-05 22.5 0.2 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ETO03070.1 - 0.028 13.7 0.1 0.049 12.9 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_33 PF13671.6 ETO03070.1 - 0.12 12.5 0.3 0.23 11.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETO03070.1 - 0.13 12.1 0.2 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 ETO03070.1 - 0.15 11.6 0.3 0.97 9.0 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain MIEAP PF16026.5 ETO03071.1 - 1.3e-09 38.6 3.7 5.5e-09 36.5 3.4 2.1 1 1 0 1 1 1 1 Mitochondria-eating protein RhoGAP PF00620.27 ETO03071.1 - 0.3 10.9 4.9 2.7 7.8 0.1 2.4 1 1 1 2 2 2 0 RhoGAP domain RPA_interact_C PF14768.6 ETO03071.1 - 0.8 10.3 3.0 1.3 9.6 0.7 2.4 1 1 1 2 2 2 0 Replication protein A interacting C-terminal WD40 PF00400.32 ETO03073.1 - 7.4e-42 140.5 5.8 2.7e-06 28.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03073.1 - 2.8e-19 69.2 0.1 0.00093 19.5 0.0 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03073.1 - 1.5e-10 40.6 0.1 0.053 12.5 0.0 5.2 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO03073.1 - 1.3e-09 38.2 0.6 0.002 18.1 0.2 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO03073.1 - 7.2e-07 28.8 8.9 0.00013 21.5 1.4 3.8 3 1 1 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO03073.1 - 1.5e-05 24.8 11.7 0.019 14.9 0.0 6.0 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO03073.1 - 0.00058 19.0 1.1 1.5 7.8 0.1 3.0 1 1 2 3 3 3 2 Coatomer WD associated region Utp8 PF10395.9 ETO03073.1 - 0.00086 17.9 1.1 0.01 14.3 0.2 2.3 1 1 2 3 3 3 1 Utp8 family DPPIV_N PF00930.21 ETO03073.1 - 0.0011 17.8 0.0 7.6 5.2 0.0 3.9 2 1 2 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nup160 PF11715.8 ETO03073.1 - 0.0058 15.3 1.2 0.13 10.9 0.2 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DNA_pol_B_2 PF03175.13 ETO03073.1 - 0.071 12.0 2.6 0.49 9.2 0.8 2.1 2 0 0 2 2 2 0 DNA polymerase type B, organellar and viral Proteasome_A_N PF10584.9 ETO03073.1 - 0.14 11.9 4.6 29 4.5 0.0 4.4 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO03074.1 - 1.2e-23 83.0 6.3 3.3e-10 40.4 0.1 6.0 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03074.1 - 4.4e-13 49.3 0.3 0.021 15.1 0.0 5.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03074.1 - 1.5e-06 27.5 1.6 0.017 14.1 0.0 3.6 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO03074.1 - 6e-06 25.0 0.0 0.0032 16.1 0.0 3.1 3 0 0 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO03074.1 - 0.00051 19.4 0.2 0.00051 19.4 0.2 3.1 2 1 1 3 3 3 1 WD40-like domain Kelch_6 PF13964.6 ETO03074.1 - 0.00052 20.2 5.2 0.48 10.8 0.1 4.8 4 1 1 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO03074.1 - 0.0027 17.3 3.7 0.47 10.1 0.1 3.3 4 0 0 4 4 4 2 Kelch motif PQQ PF01011.21 ETO03074.1 - 0.012 15.5 0.0 3.6 7.7 0.0 3.3 4 0 0 4 4 4 0 PQQ enzyme repeat WD40 PF00400.32 ETO03075.1 - 8e-17 61.3 9.1 2e-07 31.6 0.7 4.2 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03075.1 - 9.4e-08 32.3 0.0 0.0037 17.5 0.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03075.1 - 1.7e-05 23.7 0.0 0.029 13.0 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO03075.1 - 0.02 14.5 1.5 0.034 13.7 0.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) PT PF04886.12 ETO03076.1 - 4.3e-05 23.0 14.6 4.3e-05 23.0 14.6 2.4 2 0 0 2 2 2 2 PT repeat Myosin_head PF00063.21 ETO03077.1 - 9e-11 40.7 0.2 9.8e-11 40.6 0.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) DUF1877 PF08974.10 ETO03077.1 - 0.017 15.2 0.0 0.018 15.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1877) Myosin_head PF00063.21 ETO03078.1 - 3.8e-18 65.1 0.5 1.4e-17 63.2 0.7 1.7 1 1 1 2 2 2 1 Myosin head (motor domain) TPR_1 PF00515.28 ETO03080.1 - 2.1e-08 33.6 0.3 1.2e-05 24.9 0.1 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03080.1 - 1.8e-06 27.6 0.0 0.0058 16.6 0.0 2.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO03080.1 - 1.1e-05 25.6 0.0 2.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03080.1 - 0.00016 21.6 1.7 0.047 13.9 0.5 2.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03080.1 - 0.00047 20.1 0.1 0.0052 16.8 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETO03080.1 - 0.0058 16.7 0.1 0.036 14.1 0.0 2.0 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO03080.1 - 0.058 13.1 2.7 1.4 8.7 1.0 3.0 1 1 1 2 2 2 0 TPR repeat HERV-K_env_2 PF13804.6 ETO03081.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Retro-transcribing viruses envelope glycoprotein BNIP3 PF06553.12 ETO03081.1 - 0.025 14.3 1.0 0.025 14.3 1.0 2.4 2 0 0 2 2 2 0 BNIP3 Gastrin PF00918.17 ETO03081.1 - 8.3 7.4 9.3 0.48 11.4 0.7 2.7 2 1 0 2 2 2 0 Gastrin/cholecystokinin family ComGG PF14173.6 ETO03082.1 - 0.0022 18.4 1.0 0.0035 17.7 0.0 1.8 2 0 0 2 2 2 1 ComG operon protein 7 ANAPC_CDC26 PF10471.9 ETO03082.1 - 0.038 14.8 1.5 0.038 14.8 1.5 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Otopetrin PF03189.13 ETO03082.1 - 1.2 7.9 9.9 1.6 7.5 9.9 1.1 1 0 0 1 1 1 0 Otopetrin NST1 PF13945.6 ETO03082.1 - 1.2 9.2 30.8 0.67 10.0 19.1 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator HCO3_cotransp PF00955.21 ETO03082.1 - 2.7 6.7 7.5 4.6 6.0 7.5 1.3 1 0 0 1 1 1 0 HCO3- transporter family DUF3080 PF11279.8 ETO03083.1 - 0.032 13.5 0.4 0.056 12.7 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3080) Snapin_Pallidin PF14712.6 ETO03083.1 - 7.7 7.0 8.5 7.8 7.0 0.0 3.0 3 0 0 3 3 3 0 Snapin/Pallidin DUF2120 PF09893.9 ETO03085.1 - 0.055 13.6 3.7 0.063 13.4 3.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) Helicase_C PF00271.31 ETO03087.1 - 1.7e-05 25.2 0.1 4.7e-05 23.7 0.1 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DUF371 PF04027.13 ETO03087.1 - 0.077 13.0 0.1 0.23 11.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF371) Kelch_1 PF01344.25 ETO03091.1 - 4.8e-09 35.7 0.5 3.3e-05 23.4 0.1 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO03091.1 - 2.3e-06 27.7 0.6 0.0079 16.5 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO03091.1 - 5.7e-05 23.0 0.2 0.0011 18.9 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO03091.1 - 0.00047 20.4 0.1 0.1 12.9 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Destabilase PF05497.12 ETO03091.1 - 0.044 14.1 0.3 0.044 14.1 0.3 3.2 4 0 0 4 4 4 0 Destabilase GF_recep_IV PF14843.6 ETO03091.1 - 0.051 13.4 2.7 2.7 7.8 0.2 2.8 2 0 0 2 2 2 0 Growth factor receptor domain IV Noggin PF05806.12 ETO03092.1 - 0.036 14.0 2.6 0.04 13.8 0.1 2.0 1 1 1 2 2 2 0 Noggin SURF6 PF04935.12 ETO03093.1 - 0.3 10.8 8.5 0.48 10.2 8.5 1.2 1 0 0 1 1 1 0 Surfeit locus protein 6 GREB1 PF15782.5 ETO03093.1 - 5.3 4.0 13.5 6.6 3.7 13.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AAA_12 PF13087.6 ETO03094.1 - 7.3e-59 198.8 0.0 1.4e-58 197.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain UPF1_Zn_bind PF09416.10 ETO03094.1 - 2.9e-50 170.2 2.6 9.2e-50 168.6 1.2 2.2 2 0 0 2 2 2 1 RNA helicase (UPF2 interacting domain) AAA_11 PF13086.6 ETO03094.1 - 3.3e-48 164.7 4.7 1.6e-29 103.5 0.1 3.2 3 1 1 4 4 4 2 AAA domain DUF5599 PF18141.1 ETO03094.1 - 5.7e-26 90.6 0.0 1.2e-25 89.6 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5599) AAA_30 PF13604.6 ETO03094.1 - 3e-15 56.4 0.2 1.2e-13 51.2 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ETO03094.1 - 6.6e-11 42.7 0.2 3.4e-09 37.2 0.1 2.6 2 0 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ETO03094.1 - 9.4e-05 22.3 0.3 0.58 9.8 0.0 3.6 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase ResIII PF04851.15 ETO03094.1 - 0.00027 21.0 0.0 0.00055 20.0 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ETO03094.1 - 0.00042 19.7 0.8 0.012 14.9 0.0 3.3 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 ETO03094.1 - 0.00042 20.2 0.1 0.0018 18.1 0.1 2.2 2 1 0 2 2 2 1 Helicase Ribosomal_S13_N PF08069.12 ETO03094.1 - 0.00085 19.3 0.1 0.0025 17.8 0.1 1.8 1 0 0 1 1 1 1 Ribosomal S13/S15 N-terminal domain PIF1 PF05970.14 ETO03094.1 - 0.00085 18.6 0.4 0.87 8.7 0.0 2.6 3 0 0 3 3 3 2 PIF1-like helicase UvrD-helicase PF00580.21 ETO03094.1 - 0.0048 16.4 0.9 2.1 7.8 0.0 3.2 2 1 0 3 3 3 1 UvrD/REP helicase N-terminal domain ATPase PF06745.13 ETO03094.1 - 0.033 13.5 0.0 0.069 12.5 0.0 1.4 1 0 0 1 1 1 0 KaiC PhoH PF02562.16 ETO03094.1 - 0.053 13.0 0.2 0.21 11.0 0.2 2.1 1 1 0 1 1 1 0 PhoH-like protein AAA_10 PF12846.7 ETO03094.1 - 0.054 12.4 0.0 0.11 11.3 0.0 1.5 1 0 0 1 1 1 0 AAA-like domain AAA_5 PF07728.14 ETO03094.1 - 0.054 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO03094.1 - 0.071 13.4 0.0 0.33 11.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO03094.1 - 0.075 13.0 0.1 0.27 11.2 0.0 2.0 2 0 0 2 2 2 0 NACHT domain Tam41_Mmp37 PF09139.11 ETO03094.1 - 0.079 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphatidate cytidylyltransferase, mitochondrial AAA_16 PF13191.6 ETO03094.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain TANGO2 PF05742.12 ETO03095.1 - 0.048 13.7 0.8 0.078 13.0 0.6 1.5 1 1 1 2 2 2 0 Transport and Golgi organisation 2 SLATT_5 PF18160.1 ETO03095.1 - 0.27 10.5 4.5 1.9 7.7 4.5 2.0 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 EpoR_lig-bind PF09067.10 ETO03096.1 - 0.029 14.6 0.7 0.046 13.9 0.7 1.4 1 1 0 1 1 1 0 Erythropoietin receptor, ligand binding YabA PF06156.13 ETO03097.1 - 0.17 12.6 6.7 0.29 11.8 6.7 1.4 1 0 0 1 1 1 0 Initiation control protein YabA PCRF PF03462.18 ETO03097.1 - 0.36 10.7 4.6 0.55 10.1 4.6 1.2 1 0 0 1 1 1 0 PCRF domain ribosomal_L24 PF17136.4 ETO03097.1 - 0.78 10.2 5.5 0.77 10.2 0.2 2.8 1 1 2 3 3 3 0 Ribosomal proteins 50S L24/mitochondrial 39S L24 NLE PF08154.12 ETO03097.1 - 1.5 9.4 6.2 0.4 11.2 0.9 2.7 2 2 0 2 2 2 0 NLE (NUC135) domain DNA_ligase_C PF17879.1 ETO03098.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.4 1 0 0 1 1 1 0 DNA ligase C-terminal domain DUF2524 PF10732.9 ETO03098.1 - 0.24 11.7 5.2 0.21 11.9 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) DUF5526 PF17664.1 ETO03099.1 - 0.01 15.4 1.9 0.012 15.1 1.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5526) FSIP2 PF15783.5 ETO03100.1 - 0.0087 14.1 1.2 0.011 13.7 1.2 1.1 1 0 0 1 1 1 1 Fibrous sheath-interacting protein 2 Mob1_phocein PF03637.17 ETO03100.1 - 0.048 13.7 0.1 0.064 13.3 0.1 1.3 1 0 0 1 1 1 0 Mob1/phocein family FlxA PF14282.6 ETO03100.1 - 5.4 7.1 7.2 0.35 10.9 1.8 1.8 2 0 0 2 2 2 0 FlxA-like protein zf-RRPl_C4 PF17026.5 ETO03101.1 - 0.019 15.1 1.8 0.019 15.1 1.8 1.5 1 1 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type ZZ PF00569.17 ETO03101.1 - 0.12 12.3 0.4 0.12 12.3 0.4 1.9 2 0 0 2 2 2 0 Zinc finger, ZZ type PrgU PF09627.10 ETO03104.1 - 0.11 12.5 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 PrgU-like protein DUF2070 PF09843.9 ETO03105.1 - 3.2 5.9 7.5 4.2 5.5 7.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) A_deaminase PF00962.22 ETO03107.1 - 4.6e-06 26.2 0.0 5.1e-06 26.0 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase Kinesin PF00225.23 ETO03109.1 - 0.0037 16.3 1.6 0.0037 16.3 1.6 1.7 2 0 0 2 2 2 1 Kinesin motor domain CDC45 PF02724.14 ETO03110.1 - 1.5 7.0 7.0 1.7 6.8 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Pep_deformylase PF01327.21 ETO03111.1 - 3e-17 62.7 0.0 4.3e-17 62.2 0.0 1.2 1 0 0 1 1 1 1 Polypeptide deformylase DUF218 PF02698.17 ETO03111.1 - 5e-16 58.9 0.0 6.9e-16 58.5 0.0 1.2 1 0 0 1 1 1 1 DUF218 domain BatD PF13584.6 ETO03112.1 - 0.051 12.4 0.0 0.066 12.0 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance 2TM PF13239.6 ETO03112.1 - 0.1 12.9 1.3 0.2 12.0 1.3 1.4 1 0 0 1 1 1 0 2TM domain DUF3116 PF11313.8 ETO03114.1 - 0.027 14.3 0.2 0.038 13.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3116) zf-MIZ PF02891.20 ETO03116.1 - 0.0067 16.2 1.0 0.0067 16.2 1.0 2.4 3 0 0 3 3 3 1 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 ETO03116.1 - 0.33 10.8 8.6 1.2 9.0 4.4 3.3 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 ETO03117.1 - 3e-09 37.4 3.3 4.6e-06 27.3 1.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Csm1_N PF18504.1 ETO03117.1 - 0.74 10.2 23.0 0.44 10.9 4.7 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF641 PF04859.12 ETO03117.1 - 1.4 9.3 17.1 3.8 7.9 5.6 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Phage_HK97_TLTM PF06120.11 ETO03117.1 - 1.9 7.6 22.4 2.6 7.1 0.5 2.1 1 1 1 2 2 2 0 Tail length tape measure protein PKcGMP_CC PF16808.5 ETO03117.1 - 2.7 7.9 21.6 0.042 13.7 7.2 3.3 2 2 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Exonuc_VII_L PF02601.15 ETO03117.1 - 5.8 6.4 11.5 7.8 6.0 11.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit WD40 PF00400.32 ETO03118.1 - 0.0038 18.0 0.7 0.055 14.4 0.6 2.2 2 1 0 2 2 2 1 WD domain, G-beta repeat SDA1 PF05285.12 ETO03120.1 - 0.0017 17.9 6.0 0.0021 17.6 6.0 1.3 1 0 0 1 1 1 1 SDA1 YL1 PF05764.13 ETO03120.1 - 0.0019 18.4 6.5 0.0026 17.9 6.5 1.3 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 ETO03120.1 - 0.011 14.0 8.0 0.014 13.8 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO03120.1 - 0.018 13.3 9.7 0.021 13.1 9.7 1.1 1 0 0 1 1 1 0 Nop14-like family VAD1-2 PF15310.6 ETO03120.1 - 0.05 13.5 1.0 0.05 13.5 1.0 2.1 2 0 0 2 2 2 0 Vitamin A-deficiency (VAD) rat model signalling DUF3899 PF13038.6 ETO03120.1 - 0.22 12.0 0.0 0.51 10.9 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) Pox_Ag35 PF03286.14 ETO03120.1 - 0.23 11.2 8.3 0.52 10.1 8.3 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RRN3 PF05327.11 ETO03120.1 - 0.25 9.8 6.3 0.3 9.6 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF1840 PF08895.11 ETO03120.1 - 0.51 10.7 3.6 0.5 10.7 1.9 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF1840) TRAP_alpha PF03896.16 ETO03120.1 - 0.62 9.2 5.3 0.88 8.7 5.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO03120.1 - 1.1 7.3 14.8 1.4 7.0 14.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO03120.1 - 1.9 7.7 17.6 3.9 6.7 17.6 1.5 1 1 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETO03120.1 - 3.2 7.3 15.5 0.24 10.9 7.9 2.1 2 0 0 2 2 2 0 PPP4R2 TFB6 PF17110.5 ETO03120.1 - 6 6.6 8.2 11 5.7 8.2 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Cofilin_ADF PF00241.20 ETO03122.1 - 1.6e-05 24.7 0.0 2.7e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein YMF19 PF02326.15 ETO03123.1 - 0.26 12.1 7.8 3.5 8.5 1.6 2.5 2 0 0 2 2 2 0 Plant ATP synthase F0 PPR_3 PF13812.6 ETO03125.1 - 1.4e-05 25.1 0.5 0.00048 20.1 0.2 2.4 2 0 0 2 2 2 1 Pentatricopeptide repeat domain TMEM215 PF15746.5 ETO03125.1 - 0.074 12.5 0.1 0.093 12.2 0.1 1.1 1 0 0 1 1 1 0 TMEM215 family PPR_1 PF12854.7 ETO03125.1 - 0.096 12.4 3.0 8.4 6.2 0.3 2.5 2 0 0 2 2 2 0 PPR repeat DUF3510 PF12022.8 ETO03127.1 - 7.6e-08 32.8 2.0 1.4e-07 31.9 1.7 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF3510) WLM PF08325.10 ETO03127.1 - 0.027 14.5 0.3 0.05 13.7 0.2 1.3 1 1 0 1 1 1 0 WLM domain AIG1 PF04548.16 ETO03129.1 - 0.054 12.8 0.2 0.054 12.8 0.2 2.0 1 1 1 2 2 2 0 AIG1 family PAD PF03068.15 ETO03129.1 - 0.096 11.7 4.9 0.11 11.4 4.9 1.1 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) SR-25 PF10500.9 ETO03130.1 - 0.00051 19.7 43.5 0.0039 16.8 19.6 3.2 2 1 1 3 3 3 2 Nuclear RNA-splicing-associated protein Foie-gras_1 PF11817.8 ETO03130.1 - 0.0022 17.6 2.4 0.0022 17.6 2.4 1.8 2 0 0 2 2 2 1 Foie gras liver health family 1 CAF1-p150_N PF15557.6 ETO03130.1 - 0.018 15.0 1.4 0.018 15.0 1.4 2.0 2 1 0 2 2 2 0 CAF1 complex subunit p150, region binding to PCNA PPP4R2 PF09184.11 ETO03130.1 - 0.34 10.5 14.8 0.42 10.1 13.8 1.6 1 1 1 2 2 2 0 PPP4R2 Kelch_1 PF01344.25 ETO03132.1 - 0.00013 21.4 0.1 0.29 10.8 0.1 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO03132.1 - 0.15 12.4 2.5 20 5.7 0.1 4.1 3 2 1 4 4 4 0 Kelch motif adh_short_C2 PF13561.6 ETO03133.1 - 5.1e-08 32.7 0.1 6.9e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO03133.1 - 6.4e-05 22.5 0.3 8.3e-05 22.1 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase YqzE PF14038.6 ETO03133.1 - 0.066 13.2 3.3 0.1 12.6 3.3 1.3 1 0 0 1 1 1 0 YqzE-like protein SR-25 PF10500.9 ETO03133.1 - 0.89 9.1 5.0 1.1 8.8 5.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WD40 PF00400.32 ETO03134.1 - 1e-30 105.3 26.0 4.2e-07 30.5 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03134.1 - 1.1e-11 44.9 0.3 0.028 14.7 0.0 5.4 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03134.1 - 3e-08 32.8 8.7 0.1 11.3 0.3 5.2 1 1 4 5 5 5 5 Nucleoporin Nup120/160 zf_C2H2_6 PF18450.1 ETO03134.1 - 0.45 10.3 4.2 1.7 8.5 4.2 2.0 1 0 0 1 1 1 0 Zinc Finger domain CSG2 PF16965.5 ETO03135.1 - 0.002 17.1 0.9 0.002 17.1 0.9 1.8 1 1 0 2 2 2 1 Ceramide synthase regulator DUF3464 PF11947.8 ETO03135.1 - 0.0025 17.6 0.1 0.0052 16.5 0.1 1.5 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 NPR3 PF03666.13 ETO03135.1 - 0.1 11.4 7.0 0.14 10.9 7.0 1.3 1 1 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Otopetrin PF03189.13 ETO03135.1 - 0.27 10.0 8.4 0.5 9.1 1.7 2.1 2 0 0 2 2 2 0 Otopetrin PRP1_N PF06424.12 ETO03135.1 - 0.29 11.5 11.2 0.39 11.1 11.2 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Striatin PF08232.12 ETO03135.1 - 0.71 10.5 7.6 1 10.0 7.6 1.2 1 0 0 1 1 1 0 Striatin family 7TM-7TMR_HD PF07698.11 ETO03135.1 - 1.6 8.5 11.6 1.4 8.7 1.9 2.9 2 1 1 3 3 3 0 7TM receptor with intracellular HD hydrolase TSLP PF15216.6 ETO03136.1 - 0.014 15.7 0.4 0.03 14.6 0.4 1.6 1 0 0 1 1 1 0 Thymic stromal lymphopoietin AHJR-like PF18743.1 ETO03136.1 - 0.017 14.7 0.2 0.031 13.8 0.2 1.4 1 0 0 1 1 1 0 REase_AHJR-like WD40 PF00400.32 ETO03140.1 - 3.7e-10 40.2 9.4 4e-08 33.8 3.2 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03140.1 - 0.0053 17.0 0.3 0.025 14.9 0.1 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF641 PF04859.12 ETO03140.1 - 0.37 11.1 15.1 0.39 11.1 5.5 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) MMR_HSR1_C PF08438.10 ETO03140.1 - 0.73 10.4 8.4 1.3 9.7 8.4 1.3 1 0 0 1 1 1 0 GTPase of unknown function C-terminal FapA PF03961.13 ETO03140.1 - 7.9 5.0 20.1 10 4.6 20.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A NAAA-beta PF15508.6 ETO03141.1 - 0.14 12.4 0.1 0.79 10.1 0.0 2.3 2 0 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Tom22 PF04281.13 ETO03141.1 - 0.16 11.8 0.4 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 FPL PF09758.9 ETO03141.1 - 2.2 8.3 9.2 0.25 11.3 2.3 2.4 2 1 0 2 2 2 0 Uncharacterised conserved protein 7TMR-DISM_7TM PF07695.11 ETO03144.1 - 0.0056 16.6 0.0 0.0071 16.3 0.0 1.1 1 0 0 1 1 1 1 7TM diverse intracellular signalling Colicin_immun PF09204.10 ETO03145.1 - 0.043 14.3 0.7 6 7.5 0.3 3.3 2 1 0 3 3 3 0 Bacterial self-protective colicin-like immunity Muted PF14942.6 ETO03146.1 - 0.026 14.9 1.8 0.034 14.5 1.7 1.3 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein NBP1 PF08537.10 ETO03147.1 - 0.0015 18.0 19.7 0.0016 17.9 19.7 1.0 1 0 0 1 1 1 1 Fungal Nap binding protein NBP1 SHE3 PF17078.5 ETO03147.1 - 0.0029 17.4 22.0 0.0056 16.4 22.0 1.6 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 Gp-FAR-1 PF05823.12 ETO03147.1 - 0.01 16.2 14.7 0.016 15.5 14.7 1.3 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) THOC7 PF05615.13 ETO03147.1 - 0.013 15.7 9.3 0.013 15.7 9.3 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 TPR_MLP1_2 PF07926.12 ETO03147.1 - 0.016 15.3 27.4 0.038 14.0 14.6 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ETO03147.1 - 0.025 13.5 25.1 0.16 10.8 25.1 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein CENP-H PF05837.12 ETO03147.1 - 0.041 14.3 24.2 0.16 12.4 10.3 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Leu_zip PF15294.6 ETO03147.1 - 0.054 13.0 19.2 0.079 12.5 19.1 1.3 1 1 0 1 1 1 0 Leucine zipper HALZ PF02183.18 ETO03147.1 - 0.065 13.5 11.4 0.31 11.3 1.6 3.7 2 1 2 4 4 4 0 Homeobox associated leucine zipper Tropomyosin_1 PF12718.7 ETO03147.1 - 0.069 13.3 28.1 0.055 13.6 22.1 2.1 1 1 1 2 2 2 0 Tropomyosin like DUF16 PF01519.16 ETO03147.1 - 0.18 12.3 26.7 24 5.5 16.4 3.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 Filament PF00038.21 ETO03147.1 - 0.24 11.0 24.1 0.091 12.3 14.4 2.0 1 1 1 2 2 2 0 Intermediate filament protein DUF5595 PF18077.1 ETO03147.1 - 0.25 11.5 17.1 0.29 11.2 0.7 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5595) MAD PF05557.13 ETO03147.1 - 0.25 9.7 28.1 0.29 9.4 28.1 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Tho2 PF11262.8 ETO03147.1 - 0.34 10.1 25.7 0.27 10.4 11.5 2.0 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Ax_dynein_light PF10211.9 ETO03147.1 - 0.35 10.8 29.7 0.77 9.7 8.3 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain TMF_DNA_bd PF12329.8 ETO03147.1 - 0.41 10.7 31.0 2.2 8.3 3.8 3.2 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding RecG_N PF17190.4 ETO03147.1 - 0.51 11.1 11.6 0.2 12.4 6.7 2.0 1 1 1 2 2 2 0 RecG N-terminal helical domain FlaC_arch PF05377.11 ETO03147.1 - 0.82 10.1 16.9 9.3 6.7 2.6 3.7 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 ETO03147.1 - 0.85 9.7 28.7 0.65 10.1 14.7 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 ETO03147.1 - 0.86 8.9 18.8 1.3 8.3 18.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3584 PF12128.8 ETO03147.1 - 1.2 6.6 25.6 1.4 6.3 25.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) ZapB PF06005.12 ETO03147.1 - 1.2 9.6 28.2 1.6 9.2 5.3 3.1 2 2 0 2 2 2 0 Cell division protein ZapB Lectin_N PF03954.14 ETO03147.1 - 1.4 8.7 15.1 3.6 7.3 8.8 2.1 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain SlyX PF04102.12 ETO03147.1 - 1.4 9.6 25.5 6.5 7.4 4.7 3.6 1 1 2 3 3 3 0 SlyX bZIP_2 PF07716.15 ETO03147.1 - 1.5 9.0 22.3 0.36 10.9 3.4 3.4 2 1 1 3 3 3 0 Basic region leucine zipper DUF4200 PF13863.6 ETO03147.1 - 1.9 8.9 29.6 0.53 10.7 16.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF4144 PF13642.6 ETO03147.1 - 2.2 8.9 7.7 20 5.8 7.7 2.1 1 1 0 1 1 1 0 protein structure with unknown function JIP_LZII PF16471.5 ETO03147.1 - 2.4 8.4 17.8 0.16 12.1 8.4 2.8 2 2 0 2 2 2 0 JNK-interacting protein leucine zipper II YlqD PF11068.8 ETO03147.1 - 2.6 8.4 33.7 2.3 8.6 17.7 2.3 1 1 1 2 2 2 0 YlqD protein DUF3450 PF11932.8 ETO03147.1 - 2.6 7.3 26.7 0.084 12.2 15.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Fungal_TACC PF12709.7 ETO03147.1 - 3.2 8.3 25.4 1.6 9.2 3.8 3.3 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins YabA PF06156.13 ETO03147.1 - 3.2 8.4 21.3 5.5 7.7 3.8 2.7 1 1 1 2 2 2 0 Initiation control protein YabA DUF4763 PF15960.5 ETO03147.1 - 3.7 6.8 23.4 70 2.6 23.2 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) TMPIT PF07851.13 ETO03147.1 - 3.9 6.6 25.0 4 6.6 10.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein NPV_P10 PF05531.12 ETO03147.1 - 4.3 7.9 17.0 14 6.2 2.5 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Golgin_A5 PF09787.9 ETO03147.1 - 5.7 6.3 26.7 10 5.5 26.3 1.5 1 1 0 1 1 1 0 Golgin subfamily A member 5 APG6_N PF17675.1 ETO03147.1 - 6.2 7.4 27.6 3.3e+02 1.8 27.6 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF948 PF06103.11 ETO03147.1 - 9.2 6.6 10.9 15 5.9 3.4 2.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) LAP1C PF05609.12 ETO03148.1 - 0.077 12.1 12.2 0.089 11.9 12.2 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 ETO03148.1 - 0.11 11.3 15.0 0.23 10.2 15.0 1.6 1 1 0 1 1 1 0 Presenilin 7tm_1 PF00001.21 ETO03148.1 - 0.21 10.9 0.1 0.23 10.7 0.1 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DLIC PF05783.11 ETO03148.1 - 0.36 9.6 5.1 0.47 9.2 5.1 1.1 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) GAGA_bind PF06217.12 ETO03148.1 - 1.7 8.9 18.4 2.3 8.4 18.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family CCDC53 PF10152.9 ETO03148.1 - 2.8 8.3 16.2 4.6 7.7 16.2 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex MID_MedPIWI PF18296.1 ETO03148.1 - 4.5 7.0 15.2 5.4 6.7 15.2 1.1 1 0 0 1 1 1 0 MID domain of medPIWI CAML PF14963.6 ETO03148.1 - 4.5 7.3 8.3 6.8 6.7 8.3 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand PAT1 PF09770.9 ETO03148.1 - 7.9 4.6 23.8 9 4.4 23.8 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 YajC PF02699.15 ETO03150.1 - 0.19 11.6 0.8 1.1 9.2 0.2 2.6 2 1 1 3 3 3 0 Preprotein translocase subunit Peroxin-3 PF04882.12 ETO03150.1 - 0.52 9.2 6.6 3.2 6.6 0.9 2.3 2 0 0 2 2 2 0 Peroxin-3 Orf78 PF06024.12 ETO03150.1 - 0.54 10.6 9.1 0.48 10.7 5.9 2.6 2 1 0 2 2 2 0 Orf78 (ac78) zf-CCHC_4 PF14392.6 ETO03151.1 - 0.04 13.6 0.6 0.095 12.4 0.6 1.6 1 0 0 1 1 1 0 Zinc knuckle zinc_ribbon_10 PF10058.9 ETO03151.1 - 0.34 10.7 5.4 0.2 11.4 3.0 1.9 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-CCHC PF00098.23 ETO03151.1 - 3.3 7.9 6.5 0.41 10.8 1.8 2.0 2 0 0 2 2 2 0 Zinc knuckle Med2 PF11214.8 ETO03152.1 - 0.067 13.4 4.7 0.079 13.1 4.7 1.1 1 0 0 1 1 1 0 Mediator complex subunit 2 VirE_N PF08800.10 ETO03153.1 - 0.064 13.4 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 VirE N-terminal domain Baculo_PEP_C PF04513.12 ETO03156.1 - 0.01 15.9 0.1 0.012 15.6 0.1 1.0 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus U-box PF04564.15 ETO03157.1 - 2.6e-10 40.3 0.1 9e-10 38.6 0.1 1.8 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO03157.1 - 0.0069 16.5 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein CPSase_L_D3 PF02787.19 ETO03158.1 - 0.023 15.0 2.2 0.026 14.9 0.6 1.9 1 1 1 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain RPT PF13446.6 ETO03158.1 - 0.078 12.9 0.1 0.21 11.5 0.1 1.7 1 0 0 1 1 1 0 A repeated domain in UCH-protein HsbA PF12296.8 ETO03159.1 - 0.16 12.4 7.7 14 6.1 0.1 4.5 2 1 1 3 3 3 0 Hydrophobic surface binding protein A DASH_Dad1 PF08649.10 ETO03159.1 - 0.49 10.6 14.2 2.4 8.4 0.1 7.0 6 0 0 6 6 6 0 DASH complex subunit Dad1 Baculo_PEP_C PF04513.12 ETO03159.1 - 1.8 8.6 35.0 1.9 8.5 2.5 6.7 5 1 1 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus SF3A3 PF16837.5 ETO03159.1 - 2.2 8.9 11.3 2.6 8.6 0.0 5.6 5 1 1 6 6 6 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 DUF948 PF06103.11 ETO03159.1 - 6.8 7.0 31.8 1.4 9.2 0.5 7.4 6 2 2 8 8 8 0 Bacterial protein of unknown function (DUF948) Homeobox_KN PF05920.11 ETO03160.1 - 0.05 13.5 0.5 0.17 11.9 0.5 1.9 1 0 0 1 1 1 0 Homeobox KN domain Kelch_2 PF07646.15 ETO03162.1 - 0.00013 21.8 0.3 0.47 10.5 0.0 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO03162.1 - 0.0021 18.0 0.1 0.034 14.2 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO03162.1 - 0.0071 16.3 0.3 0.63 10.1 0.2 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO03162.1 - 0.55 9.9 4.7 3.9 7.1 0.1 3.1 3 0 0 3 3 3 0 Kelch motif TPR_12 PF13424.6 ETO03163.1 - 1.2e-107 352.3 13.1 1.2e-20 73.6 0.2 5.7 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03163.1 - 1.7e-66 218.4 0.0 8.9e-11 41.3 0.0 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03163.1 - 1.5e-46 153.1 1.3 9.6e-09 34.7 0.0 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03163.1 - 2.4e-44 147.4 41.8 2.5e-09 36.6 2.4 7.2 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03163.1 - 4.7e-37 123.1 43.7 8.2e-09 35.0 0.4 7.2 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03163.1 - 4.4e-35 117.0 24.6 6.7e-08 32.1 0.4 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03163.1 - 1.2e-19 69.2 14.4 0.0062 16.8 0.1 7.1 7 1 0 7 7 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03163.1 - 2.5e-11 44.0 0.0 0.083 13.6 0.0 4.5 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03163.1 - 3.7e-11 42.9 0.8 0.34 11.7 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO03163.1 - 1.6e-10 41.0 14.4 0.074 12.9 0.2 6.1 7 0 0 7 7 7 4 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO03163.1 - 1.8e-10 40.6 21.9 0.003 17.5 0.7 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03163.1 - 3.3e-10 39.9 0.0 0.68 10.9 0.0 5.2 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO03163.1 - 6.8e-10 38.8 0.0 4.6e-05 23.0 0.0 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_11 PF13414.6 ETO03163.1 - 1.2e-09 37.6 43.6 0.02 14.6 3.2 9.0 7 3 3 10 10 10 5 TPR repeat SNAP PF14938.6 ETO03163.1 - 5.5e-09 35.9 9.7 0.00076 19.0 0.4 3.9 1 1 2 4 4 4 3 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO03163.1 - 1.8e-07 31.1 28.8 0.053 13.6 0.1 6.6 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO03163.1 - 3.6e-07 30.0 18.2 1.2 9.5 0.2 6.4 6 0 0 6 6 6 1 PPR repeat SHNi-TPR PF10516.9 ETO03163.1 - 6.4e-07 28.7 0.9 2.2 7.8 0.0 6.0 7 0 0 7 7 6 1 SHNi-TPR TPR_19 PF14559.6 ETO03163.1 - 2.7e-06 27.8 0.0 0.28 11.7 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03163.1 - 2.6e-05 24.3 17.4 0.11 12.8 0.5 5.0 2 1 4 6 6 5 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO03163.1 - 3.5e-05 24.3 3.6 2.3 8.8 0.0 4.8 5 0 0 5 5 5 1 Domain of unknown function (DUF4810) RPN7 PF10602.9 ETO03163.1 - 0.00014 21.6 10.9 0.52 10.0 0.2 4.6 1 1 3 5 5 5 3 26S proteasome subunit RPN7 mRNA_cap_C PF03919.15 ETO03163.1 - 0.00043 20.9 0.1 50 4.6 0.0 4.7 3 1 0 5 5 5 0 mRNA capping enzyme, C-terminal domain YecM PF06185.12 ETO03163.1 - 0.00052 19.7 0.0 18 4.9 0.0 4.5 2 1 3 5 5 5 0 YecM protein Sel1 PF08238.12 ETO03163.1 - 0.00089 19.9 19.9 5.7 7.8 0.1 7.5 7 4 0 7 7 7 0 Sel1 repeat SPO22 PF08631.10 ETO03163.1 - 0.0018 17.9 2.1 5.6 6.4 0.0 3.5 4 0 0 4 4 3 0 Meiosis protein SPO22/ZIP4 like ATP-synt_E_2 PF08112.11 ETO03163.1 - 0.0018 18.5 14.7 3.5 8.0 0.1 6.2 6 0 0 6 6 6 1 ATP synthase epsilon subunit TPR_21 PF09976.9 ETO03163.1 - 0.0043 16.8 4.7 0.12 12.0 0.0 4.0 4 1 1 5 5 5 1 Tetratricopeptide repeat-like domain VirE_N PF08800.10 ETO03163.1 - 0.0055 16.8 3.1 21 5.2 0.0 4.9 2 1 4 6 6 6 0 VirE N-terminal domain Mob_Pre PF01076.19 ETO03163.1 - 0.007 16.2 6.8 1.5 8.6 0.1 3.9 1 1 5 6 6 6 3 Plasmid recombination enzyme DUF3568 PF12092.8 ETO03163.1 - 0.025 14.6 4.6 1.6 8.9 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3568) FATC PF02260.20 ETO03163.1 - 0.038 13.8 0.2 72 3.3 0.0 3.8 4 0 0 4 4 4 0 FATC domain s48_45 PF07422.13 ETO03163.1 - 0.18 12.4 4.6 0.96 10.0 3.2 2.7 1 1 0 1 1 1 0 Sexual stage antigen s48/45 domain Rapsyn_N PF10579.9 ETO03163.1 - 0.27 11.4 1.9 17 5.6 0.0 4.0 3 2 1 4 4 4 0 Rapsyn N-terminal myristoylation and linker region TEX29 PF15839.5 ETO03163.1 - 0.43 11.2 1.7 19 6.0 0.0 3.6 3 1 1 4 4 4 0 Testis-expressed sequence 29 protein Fis1_TPR_C PF14853.6 ETO03163.1 - 1.5 8.9 15.6 8.2 6.6 0.3 4.9 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat Pox_A32 PF04665.12 ETO03166.1 - 0.00062 19.3 0.2 0.0017 17.9 0.2 1.7 1 0 0 1 1 1 1 Poxvirus A32 protein DUF1724 PF08350.10 ETO03166.1 - 0.11 12.7 0.7 0.24 11.6 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1724) Lipoprotein_20 PF13942.6 ETO03167.1 - 0.17 11.8 0.1 0.34 10.8 0.1 1.4 2 0 0 2 2 2 0 YfhG lipoprotein zf-RRN7 PF11781.8 ETO03167.1 - 3.6 7.4 6.3 4.6 7.0 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 HEAT PF02985.22 ETO03168.1 - 2.3e-07 30.5 0.0 0.029 14.6 0.0 2.7 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 ETO03168.1 - 0.0001 22.6 0.0 0.00024 21.4 0.0 1.6 1 1 1 2 2 2 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO03168.1 - 0.00044 20.8 0.1 0.059 14.0 0.0 2.7 1 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ETO03168.1 - 0.0086 16.6 0.0 0.014 15.9 0.0 1.3 1 0 0 1 1 1 1 HEAT-like repeat Activator-TraM PF11657.8 ETO03168.1 - 0.042 13.7 0.1 0.097 12.5 0.1 1.6 1 1 0 1 1 1 0 Transcriptional activator TraM TIP120 PF08623.10 ETO03168.1 - 0.083 12.7 0.2 0.13 12.1 0.2 1.5 1 1 0 1 1 1 0 TATA-binding protein interacting (TIP20) FGase PF05013.12 ETO03168.1 - 0.093 12.9 0.0 0.1 12.8 0.0 1.2 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase HEAT_PBS PF03130.16 ETO03168.1 - 0.14 12.9 0.0 8.7 7.3 0.0 2.8 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat PRP38_assoc PF12871.7 ETO03169.1 - 1.2 9.8 110.4 36 5.0 47.9 3.4 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term GST_C PF00043.25 ETO03171.1 - 0.74 10.1 3.7 10 6.4 2.2 2.2 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain CdiI PF07262.11 ETO03171.1 - 1.9 8.3 13.2 2.8 7.7 9.3 2.2 2 0 0 2 2 2 0 CDI immunity protein DHHC PF01529.20 ETO03172.1 - 1.7 8.8 6.4 4.7 7.3 0.0 2.6 1 1 0 2 2 2 0 DHHC palmitoyltransferase DUF1474 PF07342.11 ETO03173.1 - 0.045 14.3 0.6 0.26 11.8 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1474) PPR PF01535.20 ETO03174.1 - 4.3e-06 26.6 1.1 0.032 14.5 0.1 3.1 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.6 ETO03174.1 - 3.2e-05 24.0 3.9 0.00029 21.0 0.1 2.9 3 0 0 3 3 3 1 PPR repeat family PPR_1 PF12854.7 ETO03174.1 - 0.048 13.4 1.0 0.099 12.4 0.1 2.1 3 0 0 3 3 3 0 PPR repeat 2Fe-2S_thioredx PF01257.19 ETO03174.1 - 0.089 12.6 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin WD40 PF00400.32 ETO03176.1 - 1.5e-28 98.4 6.4 1.5e-05 25.7 0.0 7.6 7 3 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03176.1 - 1.1e-14 54.5 0.2 0.0012 19.1 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO03176.1 - 1.2e-10 41.6 0.8 0.00015 21.7 0.4 3.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO03176.1 - 3.8e-08 32.7 0.0 0.01 14.8 0.0 4.3 2 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO03176.1 - 8.2e-07 28.0 0.1 0.047 12.3 0.0 3.4 2 1 1 4 4 4 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO03176.1 - 6.8e-05 22.3 0.5 1.4 8.2 0.0 3.9 2 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO03176.1 - 0.0023 17.8 2.9 12 6.0 0.0 5.4 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO03176.1 - 0.005 15.4 0.0 0.016 13.8 0.0 1.7 2 0 0 2 2 2 1 Cytochrome D1 heme domain Mid2 PF04478.12 ETO03176.1 - 0.028 14.3 0.2 0.2 11.5 0.0 2.1 1 1 1 2 2 2 0 Mid2 like cell wall stress sensor Gmad1 PF10647.9 ETO03176.1 - 0.066 13.0 0.0 8.5 6.1 0.0 2.2 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain DUF2684 PF10885.8 ETO03176.1 - 0.077 13.1 0.0 0.5 10.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2684) TLD PF07534.16 ETO03178.1 - 0.0024 18.1 1.6 0.0045 17.2 1.4 1.8 1 1 0 1 1 1 1 TLD MNSV_P7B PF06692.11 ETO03178.1 - 0.34 10.9 3.2 0.45 10.5 0.8 2.6 2 1 0 2 2 2 0 Melon necrotic spot virus P7B protein DUF2661 PF10860.8 ETO03179.1 - 0.0054 16.8 1.9 0.011 15.8 1.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2661) UBA_2 PF08587.11 ETO03180.1 - 0.041 14.0 0.0 0.16 12.1 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) VWA_3 PF13768.6 ETO03180.1 - 0.14 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain Kelch_6 PF13964.6 ETO03181.1 - 1.5e-05 25.1 0.1 0.012 15.9 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO03181.1 - 0.00069 19.6 0.1 0.0025 17.8 0.0 1.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03181.1 - 0.0044 16.6 1.1 0.0058 16.2 0.1 1.7 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO03181.1 - 0.018 15.4 0.0 0.063 13.6 0.0 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO03181.1 - 0.04 13.9 0.3 0.16 12.0 0.5 1.8 2 0 0 2 2 2 0 Kelch motif Cnd1 PF12717.7 ETO03182.1 - 6.4e-08 32.8 9.8 0.00099 19.2 0.2 3.3 1 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO03182.1 - 7.7e-08 32.0 0.0 0.74 10.2 0.0 4.9 5 0 0 5 5 4 2 HEAT repeat CLASP_N PF12348.8 ETO03182.1 - 5.7e-05 22.8 5.9 0.0028 17.3 1.1 2.4 2 1 0 2 2 2 2 CLASP N terminal SRA1 PF07304.11 ETO03182.1 - 0.0013 18.5 0.6 0.0067 16.2 0.5 2.3 1 1 1 2 2 2 1 Steroid receptor RNA activator (SRA1) HEAT_2 PF13646.6 ETO03182.1 - 0.0022 18.4 0.0 0.27 11.6 0.0 3.0 2 1 1 3 3 3 1 HEAT repeats DUF3361 PF11841.8 ETO03182.1 - 0.0031 17.5 6.0 1.6 8.7 2.8 3.8 1 1 1 2 2 2 1 Domain of unknown function (DUF3361) Urb2 PF10441.9 ETO03182.1 - 0.0035 17.3 1.2 0.011 15.7 1.1 1.8 1 1 0 1 1 1 1 Urb2/Npa2 family N_Asn_amidohyd PF14736.6 ETO03182.1 - 0.007 15.5 0.5 0.15 11.2 0.1 2.4 1 1 0 2 2 2 1 Protein N-terminal asparagine amidohydrolase DNA_alkylation PF08713.11 ETO03182.1 - 0.04 13.6 3.0 0.16 11.7 1.4 2.3 1 1 1 2 2 2 0 DNA alkylation repair enzyme RTP1_C1 PF10363.9 ETO03182.1 - 0.046 13.9 5.4 1.1 9.4 0.8 3.3 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ETO03182.1 - 0.059 13.9 0.0 40 4.9 0.0 3.9 4 0 0 4 4 3 0 HEAT-like repeat LuxT_C PF18285.1 ETO03182.1 - 0.07 13.7 1.2 11 6.6 0.3 3.5 1 1 2 3 3 3 0 Tetracycline repressor LuxT C-terminal domain Baculo_LEF-10 PF07206.11 ETO03182.1 - 0.23 11.7 1.6 1.2 9.3 0.1 2.9 2 1 0 2 2 2 0 Baculovirus late expression factor 10 (LEF-10) MA3 PF02847.17 ETO03182.1 - 0.82 9.7 8.4 1.9 8.5 0.3 4.3 2 2 4 6 6 6 0 MA3 domain P16-Arc PF04699.14 ETO03182.1 - 1.8 9.0 7.8 1 9.9 0.1 3.2 2 2 1 4 4 4 0 ARP2/3 complex 16 kDa subunit (p16-Arc) DUF5388 PF17363.2 ETO03182.1 - 4.8 7.5 7.8 12 6.1 0.2 4.2 5 0 0 5 5 4 0 Family of unknown function (DUF5388) Condensin2nSMC PF12422.8 ETO03182.1 - 5.6 7.1 9.2 5.5 7.2 0.8 3.3 2 2 1 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit DUF4798 PF16055.5 ETO03183.1 - 0.16 12.2 0.1 0.27 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) HMw1_D2 PF18254.1 ETO03184.1 - 0.021 15.2 1.6 0.076 13.4 0.5 2.7 2 0 0 2 2 2 0 HMW1 domain 2 T6PP_N PF18572.1 ETO03184.1 - 1.8 8.5 9.0 0.058 13.2 0.5 3.1 3 0 0 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain AAA PF00004.29 ETO03185.1 - 3.6e-11 43.6 0.0 0.00026 21.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO03185.1 - 4e-10 39.8 0.1 4e-06 26.9 0.0 3.6 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO03185.1 - 1.8e-09 37.3 0.0 2.6e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_22 PF13401.6 ETO03185.1 - 2.1e-07 31.3 0.0 0.038 14.3 0.0 3.1 3 0 0 3 3 2 2 AAA domain AAA_16 PF13191.6 ETO03185.1 - 9.7e-06 26.1 0.1 0.0059 17.0 0.0 3.4 3 1 0 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 ETO03185.1 - 6.1e-05 23.6 0.0 0.0018 18.8 0.0 2.7 2 0 0 2 2 2 1 ABC transporter AAA_14 PF13173.6 ETO03185.1 - 0.00013 22.0 0.0 0.028 14.4 0.0 3.0 2 0 0 2 2 2 1 AAA domain AAA_8 PF12780.7 ETO03185.1 - 0.00054 19.4 0.4 0.0059 16.0 0.0 2.8 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 MCM PF00493.23 ETO03185.1 - 0.00056 19.1 0.6 0.42 9.7 0.0 2.9 3 0 0 3 3 3 2 MCM P-loop domain RsgA_GTPase PF03193.16 ETO03185.1 - 0.00081 19.3 0.0 0.005 16.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Viral_helicase1 PF01443.18 ETO03185.1 - 0.00083 19.2 0.0 0.016 15.0 0.0 2.2 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_2 PF07724.14 ETO03185.1 - 0.0025 18.0 0.1 0.17 12.0 0.0 3.1 3 0 0 3 3 3 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ETO03185.1 - 0.0031 16.7 0.1 0.018 14.2 0.0 2.3 3 0 0 3 3 3 1 Protein of unknown function (DUF815) Rad17 PF03215.15 ETO03185.1 - 0.0035 17.3 1.4 0.12 12.2 0.0 3.4 3 0 0 3 3 3 1 Rad17 P-loop domain IstB_IS21 PF01695.17 ETO03185.1 - 0.013 15.2 0.2 1.6 8.5 0.0 3.6 4 1 0 4 4 4 0 IstB-like ATP binding protein PduV-EutP PF10662.9 ETO03185.1 - 0.014 15.1 0.2 0.057 13.2 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 ETO03185.1 - 0.017 15.1 3.7 0.34 10.8 0.0 3.6 4 0 0 4 4 3 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ETO03185.1 - 0.03 14.3 0.1 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ETO03185.1 - 0.034 14.7 0.5 1.3 9.6 0.0 3.6 3 1 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ETO03185.1 - 0.043 13.7 1.5 27 4.6 0.0 3.8 3 1 1 4 4 3 0 NTPase Mg_chelatase PF01078.21 ETO03185.1 - 0.069 12.5 0.5 4.6 6.6 0.0 3.2 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO03185.1 - 0.08 12.6 0.0 1.9 8.1 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain NACHT PF05729.12 ETO03185.1 - 0.091 12.7 0.0 0.63 9.9 0.1 2.5 2 0 0 2 2 2 0 NACHT domain AAA_3 PF07726.11 ETO03185.1 - 0.12 12.3 0.0 17 5.3 0.0 3.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETO03185.1 - 0.19 11.4 0.0 17 5.1 0.0 2.6 2 1 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO03185.1 - 0.26 11.7 2.3 2.7 8.4 0.0 3.3 3 0 0 3 3 2 0 RNA helicase AAA_19 PF13245.6 ETO03185.1 - 0.62 10.4 4.7 3.9 7.8 0.1 3.5 2 2 1 3 3 3 0 AAA domain Kelch_6 PF13964.6 ETO03187.1 - 0.00023 21.3 0.1 0.01 16.1 0.0 2.3 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO03187.1 - 0.00041 20.3 0.1 0.0071 16.3 0.0 2.3 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO03187.1 - 0.0014 18.8 0.0 0.0037 17.5 0.0 1.7 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03187.1 - 0.014 15.0 0.1 0.035 13.7 0.0 1.7 2 0 0 2 2 2 0 Kelch motif Pkinase PF00069.25 ETO03189.1 - 2.5e-10 40.2 0.0 3.3e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain DUF3510 PF12022.8 ETO03189.1 - 0.054 13.9 0.0 0.067 13.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) LPD14 PF18827.1 ETO03190.1 - 0.049 13.9 0.3 0.11 12.8 0.3 1.6 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 14 TPR_12 PF13424.6 ETO03193.1 - 4.3e-11 42.9 0.3 8e-11 42.1 0.2 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03193.1 - 3.6e-09 36.2 0.9 2.2e-07 30.5 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03193.1 - 5.5e-09 35.5 2.6 5.5e-09 35.5 2.6 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03193.1 - 2.7e-08 33.4 2.8 2.7e-08 33.4 2.8 2.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03193.1 - 2.7e-06 27.1 1.5 2.7e-06 27.1 1.5 2.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03193.1 - 1.8e-05 24.4 1.1 2.2e-05 24.1 0.1 1.7 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03193.1 - 0.00073 19.2 2.3 0.00073 19.2 2.3 2.5 2 1 0 2 2 2 1 TPR repeat TPR_6 PF13174.6 ETO03193.1 - 0.0015 19.1 0.2 0.0046 17.5 0.2 1.9 2 0 0 2 2 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03193.1 - 0.0041 17.7 0.0 0.007 17.0 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03193.1 - 0.01 16.0 1.0 0.026 14.8 0.9 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO03193.1 - 0.024 14.5 0.7 0.039 13.8 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETO03193.1 - 0.027 14.8 2.6 0.15 12.5 0.1 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF3938 PF13074.6 ETO03193.1 - 0.043 14.1 1.9 0.074 13.3 1.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3938) TPR_14 PF13428.6 ETO03193.1 - 0.24 12.3 0.0 0.42 11.5 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Chordopox_A13L PF05961.11 ETO03193.1 - 0.36 11.1 7.6 5.1 7.4 2.7 2.5 2 1 0 2 2 2 0 Chordopoxvirus A13L protein C2 PF00168.30 ETO03194.1 - 4.3e-11 43.0 0.0 1e-10 41.8 0.0 1.6 1 0 0 1 1 1 1 C2 domain CAP_GLY PF01302.25 ETO03194.1 - 1.8e-09 37.5 0.2 4.6e-09 36.2 0.2 1.7 1 0 0 1 1 1 1 CAP-Gly domain PDZ_6 PF17820.1 ETO03194.1 - 0.099 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PUB PF09409.10 ETO03195.1 - 0.064 13.2 0.7 0.22 11.5 0.7 2.0 1 1 0 1 1 1 0 PUB domain DUF908 PF06012.12 ETO03196.1 - 0.0022 17.5 0.1 0.0029 17.1 0.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) Serine_protease PF18405.1 ETO03196.1 - 0.015 14.4 0.2 0.016 14.4 0.2 1.1 1 0 0 1 1 1 0 Gammaproteobacterial serine protease DUF4720 PF15846.5 ETO03197.1 - 0.15 11.9 0.0 0.2 11.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4720) SOBP PF15279.6 ETO03198.1 - 4.4 7.8 22.7 6.1 7.4 22.7 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein WD40 PF00400.32 ETO03199.1 - 3.7e-46 154.1 19.1 3.5e-11 43.5 0.6 4.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03199.1 - 5.2e-21 74.7 0.2 0.00015 22.0 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03199.1 - 2.3e-09 37.0 0.0 0.00091 18.6 0.0 2.9 1 1 2 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO03199.1 - 1.2e-08 35.1 0.0 0.0029 17.5 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO03199.1 - 2.4e-07 30.5 0.2 4.6 7.3 0.0 4.5 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO03199.1 - 2.9e-07 29.8 0.1 1.3 7.9 0.0 4.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF727 PF05303.12 ETO03199.1 - 2.7e-06 27.4 0.0 2.2 8.4 0.0 4.0 1 1 3 4 4 4 2 Protein of unknown function (DUF727) Nup160 PF11715.8 ETO03199.1 - 3.3e-05 22.8 1.6 2 7.0 0.0 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Gmad1 PF10647.9 ETO03199.1 - 0.00026 20.9 0.7 6.4 6.4 0.0 3.5 1 1 0 2 2 2 2 Lipoprotein LpqB beta-propeller domain DUF5570 PF17731.1 ETO03199.1 - 0.00027 21.0 8.4 1.6 8.9 0.1 4.0 1 1 3 4 4 4 3 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO03199.1 - 0.00029 20.5 0.2 0.0023 17.6 0.2 2.2 1 1 1 2 2 2 1 PQQ-like domain PQQ PF01011.21 ETO03199.1 - 0.002 18.0 0.0 32 4.7 0.0 4.1 4 0 0 4 4 4 0 PQQ enzyme repeat Frtz PF11768.8 ETO03199.1 - 0.0044 15.4 0.0 0.76 8.0 0.0 2.5 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Proteasome_A_N PF10584.9 ETO03199.1 - 0.0046 16.6 4.1 24 4.7 0.1 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETO03199.1 - 0.015 13.9 0.0 1.5 7.3 0.0 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain MlaD PF02470.20 ETO03199.1 - 0.02 15.2 0.0 24 5.3 0.0 3.1 2 1 1 3 3 3 0 MlaD protein CSN4_RPN5_eIF3a PF18420.1 ETO03199.1 - 0.14 12.4 1.3 43 4.4 0.0 3.5 3 0 0 3 3 3 0 CSN4/RPN5/eIF3a helix turn helix domain Vps16_N PF04841.13 ETO03199.1 - 0.17 10.6 0.0 0.2 10.4 0.0 1.3 1 0 0 1 1 1 0 Vps16, N-terminal region GCV_T_C PF08669.11 ETO03199.1 - 0.35 10.8 0.9 21 5.1 0.0 2.9 2 1 1 3 3 3 0 Glycine cleavage T-protein C-terminal barrel domain PKD PF00801.20 ETO03199.1 - 1.7 8.5 6.3 29 4.6 0.1 3.6 1 1 2 4 4 4 0 PKD domain WD40 PF00400.32 ETO03200.1 - 5.4e-13 49.2 3.8 4.2e-05 24.2 0.1 3.6 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO03200.1 - 0.00079 18.2 0.4 0.19 10.3 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 HEAT PF02985.22 ETO03201.1 - 0.00014 21.8 0.0 0.0072 16.5 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat MMS19_N PF14500.6 ETO03201.1 - 0.0024 17.5 0.3 0.018 14.6 0.3 2.0 1 1 0 1 1 1 1 Dos2-interacting transcription regulator of RNA-Pol-II Imm30 PF15565.6 ETO03201.1 - 0.0039 17.2 1.6 0.0039 17.2 1.6 1.8 2 1 1 3 3 3 1 Immunity protein 30 Cnd1 PF12717.7 ETO03201.1 - 0.0099 15.9 4.9 0.32 11.0 0.0 2.5 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 QueH PF02677.14 ETO03201.1 - 0.016 15.3 1.1 0.022 14.9 1.1 1.2 1 0 0 1 1 1 0 Epoxyqueuosine reductase QueH CLASP_N PF12348.8 ETO03201.1 - 0.024 14.2 0.2 0.078 12.5 0.0 1.8 1 1 1 2 2 2 0 CLASP N terminal RTP1_C1 PF10363.9 ETO03201.1 - 0.033 14.4 0.1 0.98 9.6 0.0 2.2 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Swm2 PF17083.5 ETO03201.1 - 0.058 13.4 3.6 0.076 13.0 3.0 1.5 1 1 0 1 1 1 0 Nucleolar protein Swm2 LuxT_C PF18285.1 ETO03201.1 - 0.062 13.8 0.7 0.4 11.2 0.2 2.3 2 1 0 2 2 2 0 Tetracycline repressor LuxT C-terminal domain HEAT_2 PF13646.6 ETO03201.1 - 0.084 13.3 0.0 1.5 9.2 0.0 2.1 1 1 1 2 2 2 0 HEAT repeats MBT PF02820.18 ETO03202.1 - 0.021 15.2 0.0 0.045 14.1 0.0 1.5 1 0 0 1 1 1 0 mbt repeat 2_5_RNA_ligase2 PF13563.6 ETO03202.1 - 0.05 13.5 0.1 0.26 11.2 0.0 1.9 1 1 1 2 2 2 0 2'-5' RNA ligase superfamily DUF3294 PF07957.11 ETO03202.1 - 0.15 11.7 0.1 0.23 11.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Peptidase_M1 PF01433.20 ETO03203.1 - 8.4e-12 45.1 0.1 6.5e-11 42.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase family M1 domain DUF3819 PF12842.7 ETO03204.1 - 0.014 15.3 0.1 0.017 15.0 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3819) Spc7 PF08317.11 ETO03205.1 - 0.23 10.3 25.2 0.26 10.2 25.2 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 ETO03205.1 - 0.29 10.2 21.1 0.35 9.9 21.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5401 PF17380.2 ETO03205.1 - 0.36 8.8 18.4 0.4 8.7 18.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF2203 PF09969.9 ETO03205.1 - 1.1 10.0 12.2 2.3 9.0 12.1 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Mgr1 PF08602.10 ETO03205.1 - 1.1 8.0 9.4 1.3 7.8 9.4 1.2 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit TadF PF16964.5 ETO03205.1 - 1.1 8.9 8.7 1.4 8.6 8.7 1.1 1 0 0 1 1 1 0 Putative tight adherence pilin protein F DUF4446 PF14584.6 ETO03205.1 - 3.5 7.6 13.2 2.9 7.9 11.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) UPF0242 PF06785.11 ETO03205.1 - 3.7 7.6 24.9 4.2 7.4 24.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Mt_ATP-synt_D PF05873.12 ETO03205.1 - 5.6 6.8 15.6 7 6.5 11.9 2.0 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Ureide_permease PF07168.11 ETO03205.1 - 7.3 5.2 6.9 9.1 4.9 6.9 1.3 1 0 0 1 1 1 0 Ureide permease eIF-4B PF06273.11 ETO03205.1 - 7.6 5.5 13.0 8.4 5.3 13.0 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Exonuc_VII_L PF02601.15 ETO03205.1 - 9.6 5.7 13.5 13 5.3 13.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MIEAP PF16026.5 ETO03207.1 - 0.014 15.7 0.1 0.24 11.6 0.1 2.1 2 0 0 2 2 2 0 Mitochondria-eating protein RabGAP-TBC PF00566.18 ETO03208.1 - 6.9e-20 71.6 1.5 3.3e-16 59.6 0.7 2.1 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Kelch_2 PF07646.15 ETO03209.1 - 2.7e-05 23.9 0.1 0.005 16.8 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO03209.1 - 3.6e-05 23.9 0.2 0.11 12.9 0.0 2.7 2 1 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO03209.1 - 4.4e-05 23.4 0.0 0.00082 19.3 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03209.1 - 0.00037 20.0 0.5 0.0029 17.2 0.0 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO03209.1 - 0.01 15.8 0.1 0.32 11.0 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO03209.1 - 0.054 13.8 0.0 0.47 10.8 0.0 2.4 3 0 0 3 3 3 0 Galactose oxidase, central domain M20_dimer PF07687.14 ETO03211.1 - 8.5e-07 28.9 0.0 1.1e-06 28.6 0.0 1.1 1 0 0 1 1 1 1 Peptidase dimerisation domain VGPC1_C PF16799.5 ETO03212.1 - 0.013 15.4 10.6 0.013 15.4 10.6 1.9 1 1 1 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 RT_RNaseH_2 PF17919.1 ETO03213.1 - 8.9e-22 77.0 0.0 2.9e-21 75.4 0.0 1.9 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 ETO03213.1 - 2.9e-19 68.9 0.8 1e-18 67.2 0.8 2.0 1 0 0 1 1 1 1 Integrase zinc binding domain RT_RNaseH PF17917.1 ETO03213.1 - 1.1e-12 48.2 1.8 7.8e-10 39.0 0.0 3.5 3 1 1 4 4 4 2 RNase H-like domain found in reverse transcriptase rve PF00665.26 ETO03213.1 - 6.8e-11 42.4 0.9 4.1e-05 23.8 0.0 4.9 5 1 1 6 6 6 2 Integrase core domain zf-H2C2 PF09337.10 ETO03213.1 - 3.9e-08 33.4 0.0 9.3e-08 32.2 0.0 1.6 1 0 0 1 1 1 1 H2C2 zinc finger RVT_1 PF00078.27 ETO03213.1 - 0.00015 21.4 0.3 0.00037 20.1 0.3 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve_3 PF13683.6 ETO03213.1 - 0.0012 18.6 0.0 0.0046 16.7 0.0 2.1 1 0 0 1 1 1 1 Integrase core domain DUF5301 PF17225.3 ETO03213.1 - 0.11 12.9 0.1 0.11 12.9 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF5300) Zn_ribbon_recom PF13408.6 ETO03214.1 - 0.21 12.1 2.4 0.71 10.4 2.2 2.0 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain zf-CCHC PF00098.23 ETO03214.1 - 0.29 11.3 6.8 0.57 10.4 6.8 1.5 1 0 0 1 1 1 0 Zinc knuckle WD40 PF00400.32 ETO03215.1 - 0.00026 21.7 0.8 0.0022 18.8 0.6 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat NACHT PF05729.12 ETO03216.1 - 4.1e-10 39.8 0.0 8.2e-10 38.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO03216.1 - 0.00038 21.0 1.9 0.0011 19.5 0.0 2.5 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO03216.1 - 0.00039 20.7 0.2 0.0023 18.2 0.1 2.3 1 1 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 ETO03216.1 - 0.0016 18.2 0.0 0.0036 17.0 0.0 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation ATP_bind_2 PF03668.15 ETO03216.1 - 0.01 15.1 0.1 0.068 12.5 0.0 2.0 2 0 0 2 2 2 0 P-loop ATPase protein family ABC_tran PF00005.27 ETO03216.1 - 0.014 15.9 0.4 0.044 14.3 0.0 2.0 2 1 0 2 2 2 0 ABC transporter AAA PF00004.29 ETO03216.1 - 0.019 15.4 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ETO03216.1 - 0.024 14.5 4.1 0.087 12.6 0.5 2.3 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ETO03216.1 - 0.032 14.1 0.1 0.08 12.8 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase TsaE PF02367.17 ETO03216.1 - 0.04 13.9 0.1 0.18 11.8 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ETO03216.1 - 0.045 13.4 0.0 0.19 11.4 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain Zeta_toxin PF06414.12 ETO03216.1 - 0.052 12.8 0.0 0.093 12.0 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 ETO03216.1 - 0.089 13.2 0.4 2.4 8.5 0.3 2.8 1 1 1 2 2 2 0 AAA ATPase domain AAA_33 PF13671.6 ETO03216.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO03216.1 - 0.18 12.2 2.9 0.25 11.7 0.3 2.7 2 1 0 2 2 2 0 RNA helicase ABC_membrane PF00664.23 ETO03217.1 - 0.017 14.8 0.2 0.025 14.2 0.2 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region Kelch_5 PF13854.6 ETO03218.1 - 0.0001 22.2 2.7 0.17 11.9 0.2 3.3 3 1 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO03218.1 - 0.00074 19.4 4.1 1.4 9.0 0.1 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO03218.1 - 0.0029 17.8 1.1 0.17 12.2 0.0 3.3 3 1 1 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO03218.1 - 0.014 15.4 0.0 0.59 10.2 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03218.1 - 0.12 12.0 0.2 9 6.0 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO03218.1 - 0.34 11.3 3.5 2.4 8.5 0.2 3.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO03220.1 - 4.4e-07 29.9 2.8 0.031 14.6 0.2 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO03220.1 - 9.2e-07 28.8 0.2 0.0017 18.3 0.0 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03220.1 - 0.0077 15.8 1.7 0.98 9.1 0.2 3.2 3 0 0 3 3 3 1 Kelch motif Rol_Rep_N PF18106.1 ETO03220.1 - 0.031 14.6 0.6 0.17 12.2 0.1 2.5 2 0 0 2 2 2 0 Rolling Circle replication initiation protein N-terminal domain Kelch_5 PF13854.6 ETO03220.1 - 0.56 10.2 3.4 3.7 7.6 0.7 3.2 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO03221.1 - 4e-08 33.8 0.2 4.2e-06 27.4 0.2 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 ETO03222.1 - 2.1e-47 158.1 16.4 6.1e-10 39.5 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03222.1 - 1.5e-20 73.2 0.3 0.00046 20.4 0.0 7.0 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03222.1 - 3.6e-13 49.2 0.3 0.012 14.6 0.0 5.2 2 1 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO03222.1 - 7.3e-08 32.2 6.8 2.6 8.1 0.0 6.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO03222.1 - 9e-07 27.9 4.9 0.16 10.6 0.5 5.8 3 2 2 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO03222.1 - 1.9e-06 27.4 10.3 0.054 12.8 0.0 4.9 2 2 4 6 6 6 3 WD40-like domain DPPIV_N PF00930.21 ETO03222.1 - 0.0099 14.7 1.1 3.8 6.2 0.1 3.5 2 1 2 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETO03222.1 - 0.012 15.2 9.0 2.8 7.7 0.0 5.3 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Kelch_4 PF13418.6 ETO03222.1 - 0.017 15.1 2.1 0.031 14.3 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Cytochrom_D1 PF02239.16 ETO03222.1 - 0.031 12.8 6.6 1.5 7.3 0.0 3.4 2 1 2 4 4 4 0 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO03222.1 - 0.043 13.1 0.3 9.6 5.4 0.0 3.9 2 1 2 5 5 5 0 Neuroblastoma-amplified sequence, N terminal Kelch_5 PF13854.6 ETO03222.1 - 0.1 12.6 3.1 0.41 10.7 0.1 3.2 3 0 0 3 3 3 0 Kelch motif Coat_X PF07552.11 ETO03222.1 - 0.12 12.2 1.3 2.9 7.8 0.2 3.2 2 1 1 3 3 3 0 Spore Coat Protein X and V domain Nucleoporin_N PF08801.11 ETO03222.1 - 0.47 9.1 9.1 2.8 6.6 0.2 4.2 3 1 2 5 5 5 0 Nup133 N terminal like Kelch_1 PF01344.25 ETO03222.1 - 0.68 9.6 2.5 1 9.0 0.1 2.7 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO03223.1 - 7.7e-66 216.4 25.6 1.2e-10 41.8 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03223.1 - 1.8e-25 89.0 3.7 0.00018 21.7 0.0 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03223.1 - 1.7e-14 53.6 0.8 0.4 9.6 0.0 6.5 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO03223.1 - 2.6e-14 53.5 0.9 0.0024 17.8 0.0 3.4 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO03223.1 - 1.6e-13 50.7 2.4 0.00035 20.0 0.0 3.2 3 0 0 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO03223.1 - 6.5e-11 41.9 9.0 0.32 11.0 0.1 7.3 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO03223.1 - 2.3e-08 33.0 0.5 0.00066 18.3 0.0 3.8 1 1 3 4 4 4 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO03223.1 - 7.1e-08 31.6 1.2 0.0042 15.8 0.0 4.2 2 1 2 5 5 5 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO03223.1 - 9.1e-08 32.2 2.1 0.034 14.2 0.1 4.9 1 1 3 5 5 5 1 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO03223.1 - 3.9e-05 22.7 0.0 0.16 10.8 0.0 2.8 2 1 0 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) Coatomer_WDAD PF04053.14 ETO03223.1 - 9.1e-05 21.7 3.2 0.11 11.5 0.8 2.9 1 1 0 2 2 2 2 Coatomer WD associated region HPS6 PF15702.5 ETO03223.1 - 0.0033 15.5 0.0 0.57 8.1 0.0 3.0 1 1 1 3 3 3 1 Hermansky-Pudlak syndrome 6 protein Proteasome_A_N PF10584.9 ETO03223.1 - 0.0041 16.8 10.3 14 5.5 0.0 5.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETO03223.1 - 0.0093 15.6 0.1 0.57 9.7 0.1 2.8 1 1 0 2 2 2 1 PQQ-like domain Ret2_MD PF18528.1 ETO03223.1 - 0.012 15.9 0.1 38 4.8 0.0 4.7 3 3 2 5 5 5 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Plk4_PB1 PF18190.1 ETO03223.1 - 0.018 15.2 1.8 6.1 7.1 0.0 4.2 2 1 4 6 6 6 0 Polo-like Kinase 4 Polo Box 1 Gmad1 PF10647.9 ETO03223.1 - 0.023 14.5 0.0 0.067 12.9 0.0 1.8 2 1 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain PQQ PF01011.21 ETO03223.1 - 0.026 14.4 0.0 19 5.4 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat DUF727 PF05303.12 ETO03223.1 - 0.062 13.4 0.2 14 5.9 0.0 3.7 3 1 2 5 5 4 0 Protein of unknown function (DUF727) Antifungal_prot PF11402.8 ETO03223.1 - 0.16 12.2 0.7 0.76 10.1 0.2 2.3 2 0 0 2 2 2 0 Antifungal protein Menin PF05053.13 ETO03225.1 - 8.8 4.5 8.6 9.6 4.4 8.6 1.2 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 ETO03226.1 - 0.38 9.3 14.6 0.4 9.2 14.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF515 PF04415.12 ETO03226.1 - 0.39 9.0 10.5 0.64 8.4 10.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) ATG16 PF08614.11 ETO03226.1 - 0.6 10.3 8.9 0.73 10.0 7.5 1.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) F-protein PF00469.20 ETO03226.1 - 0.67 9.5 5.0 1.3 8.5 5.0 1.5 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Secretin_N_2 PF07655.13 ETO03226.1 - 1.2 9.8 36.0 0.47 11.0 4.7 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Orf78 PF06024.12 ETO03226.1 - 1.3 9.3 9.5 0.88 9.9 0.4 2.4 2 0 0 2 2 2 0 Orf78 (ac78) Neur_chan_memb PF02932.16 ETO03226.1 - 4.2 7.4 6.9 57 3.7 0.0 2.1 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO03226.1 - 5.3 5.7 8.5 8.2 5.1 8.5 1.3 1 0 0 1 1 1 0 Presenilin SSP160 PF06933.11 ETO03226.1 - 6.1 4.9 20.3 0.043 12.0 8.8 2.0 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 PBS_linker_poly PF00427.21 ETO03227.1 - 0.1 12.6 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Phycobilisome Linker polypeptide UPF0172 PF03665.13 ETO03228.1 - 0.011 15.8 1.6 0.016 15.3 1.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0172) HEAT PF02985.22 ETO03229.1 - 4.1e-18 63.9 0.2 0.00032 20.7 0.0 7.7 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 ETO03229.1 - 3e-15 56.4 0.0 7e-06 26.4 0.0 4.9 4 1 1 5 5 5 4 HEAT repeats HEAT_EZ PF13513.6 ETO03229.1 - 1.9e-09 37.8 0.0 0.0021 18.5 0.0 6.2 6 1 1 7 7 7 1 HEAT-like repeat Cnd1 PF12717.7 ETO03229.1 - 2.1e-07 31.1 29.3 9.3e-05 22.5 2.5 7.0 2 1 4 7 7 7 2 non-SMC mitotic condensation complex subunit 1 Ank_2 PF12796.7 ETO03229.1 - 8.9e-06 26.2 0.0 4.3e-05 24.0 0.0 2.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO03229.1 - 1.6e-05 24.9 0.0 0.095 13.3 0.0 3.6 2 0 0 2 2 2 2 Ankyrin repeat Vac14_Fab1_bd PF12755.7 ETO03229.1 - 3.4e-05 24.4 11.4 2 9.0 0.0 6.6 4 3 1 6 6 5 3 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETO03229.1 - 4.3e-05 23.6 10.3 1.2 9.3 0.0 6.0 1 1 5 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 ETO03229.1 - 0.0008 19.0 10.5 0.044 13.4 0.3 4.8 3 1 2 5 5 5 2 CLASP N terminal Ank_4 PF13637.6 ETO03229.1 - 0.003 18.1 0.7 0.025 15.1 0.1 3.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO03229.1 - 0.023 15.0 0.1 0.077 13.3 0.1 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) GlutR_dimer PF00745.20 ETO03229.1 - 0.097 13.1 1.1 8.7 6.9 0.1 4.2 3 0 0 3 3 3 0 Glutamyl-tRNAGlu reductase, dimerisation domain DUF4279 PF14106.6 ETO03229.1 - 0.12 12.6 2.2 17 5.6 0.1 3.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4279) Cohesin_HEAT PF12765.7 ETO03229.1 - 0.16 12.3 0.1 38 4.7 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat associated with sister chromatid cohesion Choline_sulf_C PF12411.8 ETO03229.1 - 0.46 10.3 1.7 0.81 9.5 0.1 2.2 2 0 0 2 2 1 0 Choline sulfatase enzyme C terminal Kelch_5 PF13854.6 ETO03230.1 - 0.019 14.9 0.4 4.5 7.4 0.1 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO03230.1 - 0.1 12.7 0.9 4.7 7.3 0.1 3.3 3 0 0 3 3 3 0 Kelch motif SpoVR PF04293.13 ETO03232.1 - 0.00026 19.8 1.4 0.00031 19.6 1.4 1.1 1 0 0 1 1 1 1 SpoVR like protein Phage_Gp23 PF10669.9 ETO03232.1 - 0.022 15.1 5.6 0.051 13.9 5.6 1.6 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) OAD_gamma PF04277.13 ETO03232.1 - 0.14 12.7 1.9 0.23 12.1 1.9 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Atrophin-1 PF03154.15 ETO03232.1 - 0.36 9.0 2.4 0.41 8.9 2.4 1.0 1 0 0 1 1 1 0 Atrophin-1 family Spore_III_AB PF09548.10 ETO03232.1 - 0.64 10.1 5.7 1 9.5 5.7 1.3 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) PIN_4 PF13638.6 ETO03232.1 - 1.3 9.3 6.0 4.8 7.5 5.8 1.9 1 1 0 1 1 1 0 PIN domain FAM193_C PF15914.5 ETO03234.1 - 0.084 12.6 2.3 0.19 11.5 2.3 1.6 1 0 0 1 1 1 0 FAM193 family C-terminal NACHT PF05729.12 ETO03236.1 - 0.00034 20.6 1.3 0.011 15.7 0.2 2.1 2 0 0 2 2 2 2 NACHT domain S6OS1 PF15676.5 ETO03237.1 - 0.15 10.5 1.4 0.16 10.4 1.4 1.1 1 0 0 1 1 1 0 Six6 opposite strand transcript 1 family zf-TRAF PF02176.18 ETO03238.1 - 2.3e-07 31.4 2.5 1.2e-06 29.1 2.5 2.3 1 0 0 1 1 1 1 TRAF-type zinc finger SOGA PF11365.8 ETO03238.1 - 0.11 13.6 0.1 0.11 13.6 0.1 2.7 3 0 0 3 3 3 0 Protein SOGA zf-Tim10_DDP PF02953.15 ETO03239.1 - 0.13 11.9 0.3 0.51 10.0 0.3 2.0 1 0 0 1 1 1 0 Tim10/DDP family zinc finger Nebulin PF00880.18 ETO03241.1 - 0.14 12.1 0.2 0.25 11.3 0.0 1.6 2 0 0 2 2 2 0 Nebulin repeat Spt5_N PF11942.8 ETO03244.1 - 0.0024 18.8 2.0 0.0063 17.5 2.0 1.7 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal BSP_II PF05432.11 ETO03244.1 - 0.0059 16.3 6.4 0.0089 15.8 6.4 1.2 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Sporozoite_P67 PF05642.11 ETO03244.1 - 0.89 7.6 5.1 1.4 6.9 5.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Sec7 PF01369.20 ETO03245.1 - 2.2e-58 196.9 0.6 2.2e-58 196.9 0.6 1.6 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 ETO03245.1 - 2.9e-13 50.0 0.3 9e-13 48.4 0.1 2.0 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3641 PF12345.8 ETO03245.1 - 0.086 12.9 0.0 0.31 11.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3641) DUF1296 PF06972.11 ETO03245.1 - 0.13 12.5 2.4 17 5.7 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) DCB PF16213.5 ETO03246.1 - 1.7e-20 73.5 2.8 1.7e-20 73.5 2.8 2.9 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 TPR_1 PF00515.28 ETO03246.1 - 2.8e-10 39.6 3.7 1.6e-05 24.5 0.4 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat Sec7_N PF12783.7 ETO03246.1 - 3.6e-10 40.0 1.6 3.6e-10 40.0 1.6 2.6 3 0 0 3 3 3 1 Guanine nucleotide exchange factor in Golgi transport N-terminal TPR_2 PF07719.17 ETO03246.1 - 1.1e-08 34.5 1.5 0.0019 18.2 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03246.1 - 1.2e-06 28.1 0.4 2.3e-06 27.2 0.4 1.4 1 0 0 1 1 1 1 TPR repeat TPR_19 PF14559.6 ETO03246.1 - 0.00048 20.6 0.1 0.0014 19.0 0.0 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03246.1 - 0.025 14.7 2.8 0.47 10.8 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03246.1 - 0.12 13.2 0.0 0.4 11.6 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat Arg_tRNA_synt_N PF03485.16 ETO03246.1 - 0.16 12.6 0.8 0.75 10.4 0.8 2.1 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain FOXP-CC PF16159.5 ETO03246.1 - 1.1 9.9 10.3 7.4 7.3 10.3 2.4 1 0 0 1 1 1 0 FOXP coiled-coil domain zf-RING_7 PF02591.15 ETO03246.1 - 4.6 7.5 5.8 0.49 10.6 1.0 1.9 2 0 0 2 2 2 0 C4-type zinc ribbon domain Sulfotransfer_4 PF17784.1 ETO03247.1 - 6.7e-21 75.1 0.6 1.3e-20 74.2 0.6 1.4 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO03247.1 - 9.1e-05 22.9 0.2 0.7 10.2 0.0 2.7 1 1 0 2 2 2 2 Sulfotransferase family DUF1981 PF09324.10 ETO03250.1 - 2.4e-30 104.2 12.3 4.5e-30 103.3 0.1 4.2 4 0 0 4 4 4 2 Domain of unknown function (DUF1981) Importin_rep_5 PF18816.1 ETO03250.1 - 0.03 14.6 0.0 0.088 13.1 0.0 1.8 1 0 0 1 1 1 0 Importin repeat WD40 PF00400.32 ETO03252.1 - 7.6e-12 45.6 9.2 5.6e-05 23.8 1.8 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO03252.1 - 0.00022 20.0 0.7 0.064 11.9 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO03252.1 - 0.013 15.8 0.1 0.5 10.7 0.0 2.5 2 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_12 PF13424.6 ETO03253.1 - 3.7e-37 126.5 8.3 1.7e-12 47.5 0.2 3.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03253.1 - 2.4e-33 113.1 0.0 4.2e-10 39.2 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03253.1 - 2.3e-25 87.3 17.3 1.7e-08 33.9 0.5 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03253.1 - 5.7e-24 82.4 2.2 3e-08 33.1 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03253.1 - 7.6e-18 63.1 12.1 1.5e-05 24.7 0.4 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03253.1 - 7.8e-17 60.0 16.5 3.3e-05 23.7 0.5 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03253.1 - 9.2e-10 38.2 6.0 0.0041 17.4 0.2 4.5 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03253.1 - 7.1e-08 32.0 19.2 0.093 12.4 0.2 5.8 4 3 2 6 6 6 4 TPR repeat DUF5113 PF17140.4 ETO03253.1 - 4.4e-07 29.9 5.1 0.19 11.5 0.2 3.0 2 1 1 3 3 3 3 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO03253.1 - 2.5e-06 27.8 0.0 4.4 8.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO03253.1 - 4e-05 23.6 8.1 0.089 12.9 0.2 3.1 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 ETO03253.1 - 0.00011 22.3 1.1 0.028 14.5 0.2 2.3 1 1 1 2 2 2 2 Domain of Unknown Function (DUF3856) SNAP PF14938.6 ETO03253.1 - 0.00024 20.6 0.5 0.00043 19.8 0.5 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETO03253.1 - 0.00029 20.9 1.8 0.1 12.9 0.1 3.1 3 0 0 3 3 3 1 PPR repeat TPR_6 PF13174.6 ETO03253.1 - 0.00035 21.0 0.6 0.81 10.5 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03253.1 - 0.00069 20.2 0.0 3.3 8.5 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO03253.1 - 0.0007 19.1 1.2 3.9 7.1 0.0 4.2 4 2 1 5 5 5 1 Helix-turn-helix bacterial domain TPR_3 PF07720.12 ETO03253.1 - 0.0046 16.9 5.8 0.5 10.4 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat RPN7 PF10602.9 ETO03253.1 - 0.0057 16.4 1.9 0.41 10.3 0.2 2.4 1 1 1 2 2 2 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETO03253.1 - 0.0069 16.9 0.2 0.23 12.0 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Mob_Pre PF01076.19 ETO03253.1 - 0.013 15.4 0.6 0.018 14.9 0.3 1.4 1 1 0 1 1 1 0 Plasmid recombination enzyme ATP-synt_E_2 PF08112.11 ETO03253.1 - 0.026 14.8 0.3 8.8 6.7 0.1 2.4 2 0 0 2 2 2 0 ATP synthase epsilon subunit Myosin_tail_1 PF01576.19 ETO03253.1 - 0.033 12.0 0.2 0.14 9.9 0.0 1.8 2 0 0 2 2 2 0 Myosin tail TPR_MalT PF17874.1 ETO03253.1 - 0.034 13.5 0.0 0.066 12.6 0.0 1.5 1 1 0 1 1 1 0 MalT-like TPR region DUF3450 PF11932.8 ETO03253.1 - 0.039 13.3 0.3 27 4.0 0.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF2225 PF09986.9 ETO03253.1 - 0.04 13.7 1.0 0.15 11.8 0.9 1.7 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF2977 PF11192.8 ETO03253.1 - 0.064 13.4 0.1 6.1 7.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2977) DUF357 PF04010.13 ETO03253.1 - 0.15 12.1 3.5 2.4 8.3 0.1 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF357) Fis1_TPR_C PF14853.6 ETO03253.1 - 0.37 10.9 6.8 8.1 6.6 0.4 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat rRNA_processing PF08524.11 ETO03254.1 - 0.05 13.6 11.1 0.071 13.1 11.1 1.2 1 0 0 1 1 1 0 rRNA processing Moulting_cycle PF04870.16 ETO03254.1 - 0.21 10.8 9.8 0.24 10.6 9.8 1.1 1 0 0 1 1 1 0 Moulting cycle DUF4710 PF15828.5 ETO03254.1 - 3.2 7.9 8.8 7.4 6.8 8.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4710) Filament PF00038.21 ETO03255.1 - 0.0013 18.4 21.0 0.0013 18.4 21.0 2.1 1 1 1 2 2 2 1 Intermediate filament protein TPR_MLP1_2 PF07926.12 ETO03255.1 - 0.0098 16.0 46.0 0.29 11.2 29.0 3.1 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein DHR10 PF18595.1 ETO03255.1 - 0.028 14.5 9.6 0.028 14.5 9.6 3.5 1 1 3 4 4 4 0 Designed helical repeat protein 10 domain DUF1633 PF07794.11 ETO03255.1 - 0.045 11.9 5.4 0.053 11.7 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1633) TMF_DNA_bd PF12329.8 ETO03255.1 - 0.085 12.9 50.8 0.77 9.8 13.1 4.0 1 1 3 4 4 4 0 TATA element modulatory factor 1 DNA binding GAS PF13851.6 ETO03255.1 - 0.16 11.3 50.8 1.6 8.1 28.4 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 ETO03255.1 - 0.47 9.3 37.6 0.62 8.9 37.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Tropomyosin_1 PF12718.7 ETO03255.1 - 0.56 10.3 48.1 0.25 11.5 38.4 2.8 1 1 1 2 2 1 0 Tropomyosin like SHE3 PF17078.5 ETO03255.1 - 0.63 9.7 38.9 3 7.5 38.9 1.8 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF3450 PF11932.8 ETO03255.1 - 0.64 9.3 37.5 3.4 6.9 16.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 ETO03255.1 - 0.81 10.2 47.4 3 8.4 40.4 3.0 2 1 0 2 2 2 0 Apg6 coiled-coil region ADIP PF11559.8 ETO03255.1 - 1 9.4 45.6 1.1 9.3 13.8 2.4 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DUF3584 PF12128.8 ETO03255.1 - 1.1 6.7 36.2 1.5 6.2 36.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) EzrA PF06160.12 ETO03255.1 - 2 6.5 38.7 0.089 11.0 8.9 2.1 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Spc7 PF08317.11 ETO03255.1 - 2.1 7.1 45.2 1.3 7.8 23.8 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ETO03255.1 - 2.3 8.2 43.4 0.025 14.6 24.8 2.4 1 1 1 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Golgin_A5 PF09787.9 ETO03255.1 - 3.8 6.9 43.6 2.4 7.6 21.4 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Seryl_tRNA_N PF02403.22 ETO03255.1 - 4.2 7.6 41.6 0.38 11.0 17.7 3.1 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 ETO03255.1 - 4.5 7.4 43.7 1.3 9.2 24.0 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Cep57_CLD_2 PF14197.6 ETO03255.1 - 5 7.3 30.8 0.048 13.7 5.8 3.7 2 1 0 2 2 1 0 Centrosome localisation domain of PPC89 AAA_13 PF13166.6 ETO03255.1 - 5.8 5.4 35.9 1.8 7.1 22.8 2.0 1 1 1 2 2 2 0 AAA domain Nup88 PF10168.9 ETO03255.1 - 6 4.5 32.7 7.4 4.2 32.7 1.1 1 0 0 1 1 1 0 Nuclear pore component RR_TM4-6 PF06459.12 ETO03255.1 - 6.5 6.5 28.8 6.1 6.6 28.0 1.3 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 Rootletin PF15035.6 ETO03255.1 - 7.7 6.5 37.6 29 4.6 37.6 2.0 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion KASH_CCD PF14662.6 ETO03255.1 - 8.7 6.1 43.7 11 5.8 42.8 1.6 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Swi5 PF07061.11 ETO03255.1 - 9.3 6.4 40.6 0.52 10.4 9.1 4.2 1 1 2 3 3 3 0 Swi5 UQ_con PF00179.26 ETO03257.1 - 0.00073 19.2 0.1 0.0012 18.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF4014 PF13198.6 ETO03257.1 - 0.61 10.5 4.2 1.5 9.3 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4014) Arm PF00514.23 ETO03258.1 - 5.6e-24 83.4 14.8 1.4e-07 31.3 0.0 5.5 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO03258.1 - 3e-08 34.0 9.1 0.0018 18.7 0.2 5.0 4 1 1 5 5 5 4 HEAT-like repeat Cnd1 PF12717.7 ETO03258.1 - 3e-07 30.6 0.3 1.3e-06 28.5 0.0 2.2 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO03258.1 - 1.8e-05 25.0 3.4 0.034 14.5 0.1 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT PF02985.22 ETO03258.1 - 0.00084 19.4 7.6 0.16 12.3 0.0 4.9 6 0 0 6 6 6 1 HEAT repeat Proteasom_PSMB PF10508.9 ETO03258.1 - 0.0065 15.0 1.4 0.0094 14.5 0.3 1.8 2 0 0 2 2 2 1 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.8 ETO03258.1 - 0.0076 16.4 0.5 0.063 13.4 0.2 2.2 2 0 0 2 2 2 1 V-ATPase subunit H CHASE6_C PF17150.4 ETO03258.1 - 0.072 13.8 1.0 16 6.3 0.0 3.4 2 1 1 4 4 4 0 C-terminal domain of two-partite extracellular sensor domain SdrG_C_C PF10425.9 ETO03259.1 - 0.024 14.7 1.6 0.063 13.4 0.2 2.2 2 0 0 2 2 2 0 C-terminus of bacterial fibrinogen-binding adhesin NAPRTase_N PF17767.1 ETO03259.1 - 0.057 13.8 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Phage_T4_gp36 PF03903.13 ETO03259.1 - 0.15 12.0 1.4 0.34 10.9 0.3 1.9 2 0 0 2 2 2 0 Phage T4 tail fibre NTP_transf_7 PF07984.12 ETO03260.1 - 0.1 11.8 0.1 0.13 11.5 0.1 1.2 1 0 0 1 1 1 0 Nucleotidyltransferase DUF1361 PF07099.11 ETO03261.1 - 0.025 14.6 0.1 0.032 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1361) OS-D PF03392.13 ETO03262.1 - 0.0027 17.8 1.5 0.005 16.9 1.5 1.5 1 0 0 1 1 1 1 Insect pheromone-binding family, A10/OS-D IPK PF03770.16 ETO03262.1 - 0.0086 15.9 2.0 0.032 14.1 2.0 1.8 1 1 0 1 1 1 1 Inositol polyphosphate kinase MMS19_N PF14500.6 ETO03262.1 - 0.019 14.5 0.1 0.023 14.3 0.1 1.2 1 0 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Hydrolase_3 PF08282.12 ETO03262.1 - 0.038 13.7 4.6 0.043 13.6 4.6 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase NLE PF08154.12 ETO03262.1 - 0.11 13.1 0.4 0.54 10.8 0.0 2.2 3 0 0 3 3 3 0 NLE (NUC135) domain DUF3887 PF13026.6 ETO03262.1 - 0.8 10.6 4.5 3 8.7 1.8 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3887) zf-TRAF PF02176.18 ETO03263.1 - 4.2e-07 30.5 3.7 4.2e-07 30.5 3.7 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO03263.1 - 0.0066 16.9 3.0 0.015 15.8 3.0 1.6 1 0 0 1 1 1 1 TRAF-like zinc-finger DUF2981 PF11200.8 ETO03263.1 - 1.2 8.8 5.5 1.4 8.6 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SRP19 PF01922.17 ETO03263.1 - 1.7 9.6 5.9 0.63 11.0 0.8 2.2 1 1 1 2 2 2 0 SRP19 protein Cofac_haem_bdg PF04187.13 ETO03264.1 - 0.0022 18.0 0.2 0.0063 16.5 0.0 1.8 2 0 0 2 2 2 1 Haem-binding uptake, Tiki superfamily, ChaN PDGF_N PF04692.13 ETO03264.1 - 0.66 10.8 3.5 48 4.8 0.0 2.5 2 0 0 2 2 2 0 Platelet-derived growth factor, N terminal region DUF445 PF04286.12 ETO03265.1 - 0.041 13.7 0.2 0.21 11.3 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Mrpl_C PF18502.1 ETO03265.1 - 0.055 13.8 1.6 0.069 13.4 0.4 1.7 2 0 0 2 2 2 0 54S ribosomal protein L8 C-terminal domain DUF3484 PF11983.8 ETO03265.1 - 0.11 13.6 0.2 0.42 11.8 0.0 1.9 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch ComGF PF15980.5 ETO03265.1 - 0.13 12.6 5.3 0.53 10.7 1.6 2.4 2 0 0 2 2 2 0 Putative Competence protein ComGF SPARC_Ca_bdg PF10591.9 ETO03266.1 - 0.041 14.2 0.0 0.055 13.8 0.0 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region TPR_12 PF13424.6 ETO03267.1 - 4.2e-67 222.4 7.5 2.6e-21 75.7 0.1 3.4 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03267.1 - 4.1e-44 147.3 0.0 1e-10 41.1 0.0 4.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03267.1 - 2.2e-34 114.9 0.6 1.6e-08 33.9 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03267.1 - 1.5e-28 97.4 24.7 2.9e-08 33.2 0.5 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03267.1 - 5.5e-23 79.2 27.0 1.5e-06 28.0 0.9 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03267.1 - 2.4e-19 67.8 17.1 2.1e-05 24.3 0.3 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03267.1 - 1.5e-15 56.4 9.1 0.0028 17.9 0.1 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat DUF5113 PF17140.4 ETO03267.1 - 5.9e-11 42.4 7.1 0.06 13.2 0.1 4.0 4 0 0 4 4 4 3 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO03267.1 - 8.2e-08 32.1 14.6 0.031 14.3 0.2 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat PPR PF01535.20 ETO03267.1 - 9.8e-06 25.5 7.9 0.46 10.9 0.1 4.0 4 0 0 4 4 4 2 PPR repeat TPR_14 PF13428.6 ETO03267.1 - 7.1e-05 23.3 0.0 0.86 10.6 0.0 3.9 1 1 3 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03267.1 - 0.00011 22.3 10.9 0.35 11.1 0.3 3.5 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 DUF3450 PF11932.8 ETO03267.1 - 0.00012 21.5 2.9 0.57 9.4 0.0 3.3 1 1 2 3 3 3 2 Protein of unknown function (DUF3450) TPR_16 PF13432.6 ETO03267.1 - 0.00027 21.5 0.0 6.9 7.4 0.0 3.5 1 1 3 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03267.1 - 0.00072 20.0 1.6 10 7.0 0.0 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO03267.1 - 0.0015 17.9 0.0 0.0035 16.8 0.0 1.5 1 1 1 2 2 2 1 MalT-like TPR region RPN7 PF10602.9 ETO03267.1 - 0.0026 17.5 5.4 0.085 12.6 0.3 3.2 1 1 2 3 3 3 1 26S proteasome subunit RPN7 YecM PF06185.12 ETO03267.1 - 0.0063 16.2 0.1 1.9 8.2 0.0 3.0 1 1 2 3 3 3 1 YecM protein TPR_11 PF13414.6 ETO03267.1 - 0.0073 16.0 27.2 0.29 10.9 0.6 7.3 4 4 4 8 8 8 2 TPR repeat mRNA_cap_C PF03919.15 ETO03267.1 - 0.011 16.4 0.0 15 6.2 0.0 3.7 1 1 2 3 3 2 0 mRNA capping enzyme, C-terminal domain FATC PF02260.20 ETO03267.1 - 0.021 14.6 0.4 5.4 6.9 0.0 3.3 4 0 0 4 4 4 0 FATC domain DUF627 PF04781.12 ETO03267.1 - 0.025 14.6 9.3 1.8 8.6 0.2 3.9 2 1 1 4 4 4 0 Protein of unknown function (DUF627) Mob_Pre PF01076.19 ETO03267.1 - 0.026 14.4 3.3 0.84 9.4 0.5 2.1 1 1 1 2 2 2 0 Plasmid recombination enzyme OrfA PF17495.2 ETO03267.1 - 0.095 12.9 0.0 57 3.9 0.0 3.3 1 1 3 4 4 4 0 Vpr-like OrfA Vps39_1 PF10366.9 ETO03267.1 - 0.22 11.8 7.9 22 5.4 0.2 3.9 1 1 1 4 4 4 0 Vacuolar sorting protein 39 domain 1 Pep3_Vps18 PF05131.14 ETO03267.1 - 0.24 11.2 2.0 16 5.3 0.1 3.4 4 0 0 4 4 4 0 Pep3/Vps18/deep orange family 14-3-3 PF00244.20 ETO03267.1 - 0.42 10.1 5.7 0.11 12.0 0.5 2.2 1 1 0 2 2 2 0 14-3-3 protein MIT PF04212.18 ETO03267.1 - 0.57 10.3 14.9 3.5 7.7 0.2 4.1 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 ETO03267.1 - 1.2 8.8 4.6 32 4.2 0.1 3.4 3 1 0 4 4 4 0 Tetratricopeptide repeat-like domain ATP-synt_E_2 PF08112.11 ETO03267.1 - 1.7 9.0 10.3 3.8 7.9 0.0 3.8 4 0 0 4 4 4 0 ATP synthase epsilon subunit Kelch_3 PF13415.6 ETO03268.1 - 0.00011 22.4 0.2 0.00089 19.5 0.0 2.5 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO03268.1 - 0.00033 20.5 0.1 0.032 14.2 0.1 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO03268.1 - 0.0012 18.4 0.3 0.011 15.4 0.6 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO03268.1 - 0.011 15.7 0.5 0.17 11.9 0.2 2.3 1 1 0 2 2 2 0 Galactose oxidase, central domain DUF2593 PF10767.9 ETO03268.1 - 0.093 12.8 0.1 9.3 6.3 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2593) Kelch_6 PF13964.6 ETO03268.1 - 0.29 11.5 2.8 3.8 7.9 0.0 3.1 3 2 0 3 3 3 0 Kelch motif Zip PF02535.22 ETO03269.1 - 0.14 11.4 6.3 0.19 10.9 6.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter FAM76 PF16046.5 ETO03269.1 - 2.1 7.6 6.0 2.8 7.2 6.0 1.1 1 0 0 1 1 1 0 FAM76 protein GEMIN8 PF15348.6 ETO03269.1 - 2.2 8.6 14.3 1 9.6 6.7 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 SelP_N PF04592.14 ETO03269.1 - 3.7 6.9 21.8 5.5 6.3 21.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region CagA PF03507.13 ETO03270.1 - 0.94 9.4 5.5 1.2 9.0 5.5 1.1 1 0 0 1 1 1 0 CagA exotoxin GCIP PF13324.6 ETO03271.1 - 0.00092 18.9 6.2 0.0012 18.5 6.2 1.2 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting Ferlin_C PF16165.5 ETO03271.1 - 0.5 10.3 2.4 0.74 9.8 2.4 1.3 1 0 0 1 1 1 0 Ferlin C-terminus TBCC_N PF16752.5 ETO03271.1 - 0.96 9.9 12.4 6.1 7.3 0.0 2.2 1 1 1 2 2 2 0 Tubulin-specific chaperone C N-terminal domain Adaptin_binding PF10199.9 ETO03271.1 - 1.4 9.6 12.9 1.3 9.6 12.0 1.6 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 PDGF_N PF04692.13 ETO03271.1 - 3.4 8.5 8.3 4.1 8.2 6.5 2.2 2 1 0 2 2 2 0 Platelet-derived growth factor, N terminal region SH3_12 PF18129.1 ETO03272.1 - 1.3e-15 57.2 0.4 2.7e-15 56.2 0.4 1.5 1 0 0 1 1 1 1 Xrn1 SH3-like domain Band_3_cyto PF07565.13 ETO03272.1 - 0.0064 16.3 5.7 0.011 15.6 5.7 1.4 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Cellulose_synt PF03552.14 ETO03272.1 - 0.014 13.9 0.4 0.02 13.4 0.4 1.2 1 0 0 1 1 1 0 Cellulose synthase zf-RRPl_C4 PF17026.5 ETO03273.1 - 0.53 10.4 7.2 0.39 10.9 5.5 1.7 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-C3HC4_2 PF13923.6 ETO03273.1 - 2 8.4 7.8 4.3 7.3 4.3 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) AAA_5 PF07728.14 ETO03275.1 - 0.0079 16.2 0.0 0.47 10.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO03275.1 - 0.0099 16.2 0.0 0.017 15.4 0.0 1.4 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ETO03275.1 - 0.015 15.8 0.0 0.017 15.5 0.0 1.1 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ERAP1_C PF11838.8 ETO03276.1 - 0.082 12.4 0.0 0.097 12.2 0.0 1.1 1 0 0 1 1 1 0 ERAP1-like C-terminal domain YscO-like PF16789.5 ETO03277.1 - 0.013 15.5 2.2 0.022 14.8 2.0 1.6 1 1 0 1 1 1 0 YscO-like protein Phosphoesterase PF04185.14 ETO03278.1 - 0.15 11.2 6.6 0.41 9.8 6.6 1.7 1 1 0 1 1 1 0 Phosphoesterase family Sin_N PF04801.13 ETO03278.1 - 0.29 10.3 15.1 0.33 10.1 15.1 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region GIDA_assoc PF13932.6 ETO03278.1 - 0.82 9.8 11.8 0.95 9.6 11.8 1.1 1 0 0 1 1 1 0 GidA associated domain FAM176 PF14851.6 ETO03278.1 - 1 9.0 5.0 1.7 8.3 5.0 1.4 1 0 0 1 1 1 0 FAM176 family BcrAD_BadFG PF01869.20 ETO03279.1 - 0.005 16.4 0.0 0.0063 16.0 0.0 1.1 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family DUF2457 PF10446.9 ETO03280.1 - 4 6.5 25.2 4.1 6.4 25.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Vfa1 PF08432.10 ETO03280.1 - 7.5 6.8 16.1 8.2 6.7 16.1 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 WD40 PF00400.32 ETO03282.1 - 0.0026 18.5 0.6 0.026 15.4 0.2 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat SprB PF13573.6 ETO03282.1 - 0.1 12.4 3.4 5.1 6.9 0.1 2.2 2 0 0 2 2 2 0 SprB repeat RVT_1 PF00078.27 ETO03284.1 - 5e-05 22.9 0.4 0.00013 21.6 0.0 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF2951 PF11166.8 ETO03286.1 - 0.042 14.1 6.4 0.69 10.2 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DUF2304 PF10066.9 ETO03286.1 - 0.15 12.2 5.2 0.062 13.5 2.1 2.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) ETRAMP PF09716.10 ETO03286.1 - 7.8 6.6 12.5 1.2 9.2 3.5 2.6 1 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Tic22 PF04278.12 ETO03287.1 - 0.014 14.7 0.5 0.021 14.2 0.1 1.5 2 0 0 2 2 2 0 Tic22-like family NAPRTase_N PF17767.1 ETO03287.1 - 0.019 15.3 1.3 0.03 14.7 1.3 1.4 1 0 0 1 1 1 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain C_Hendra PF16821.5 ETO03287.1 - 0.21 11.4 8.0 0.083 12.8 4.7 1.8 1 1 1 2 2 2 0 C protein from hendra and measles viruses Nop25 PF09805.9 ETO03287.1 - 0.55 10.7 7.4 0.98 9.9 7.1 1.6 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) WD40 PF00400.32 ETO03289.1 - 0.0018 19.1 0.1 0.004 17.9 0.1 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat ENTH PF01417.20 ETO03289.1 - 0.003 17.6 0.6 0.026 14.6 0.5 2.2 1 1 1 2 2 2 1 ENTH domain WD40 PF00400.32 ETO03291.1 - 4e-15 55.9 1.5 7.6e-10 39.2 0.1 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03291.1 - 0.0026 18.0 0.3 0.074 13.4 0.2 2.3 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO03291.1 - 0.0045 15.8 2.9 0.72 8.5 0.3 2.3 1 1 1 2 2 2 2 Nup133 N terminal like HSCB_C PF07743.13 ETO03292.1 - 2.2 8.8 7.8 0.42 11.1 0.4 3.5 4 0 0 4 4 4 0 HSCB C-terminal oligomerisation domain DUF2700 PF10912.8 ETO03293.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2700) DUF3492 PF11997.8 ETO03294.1 - 0.14 11.9 0.1 0.23 11.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) CBFB_NFYA PF02045.15 ETO03295.1 - 0.7 10.6 7.4 0.11 13.2 3.4 1.7 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B ASL_C PF08328.11 ETO03296.1 - 0.083 13.0 0.7 0.35 11.0 0.2 2.2 2 1 0 2 2 2 0 Adenylosuccinate lyase C-terminal KIP1 PF07765.12 ETO03296.1 - 0.28 11.3 0.1 0.28 11.3 0.1 3.5 3 2 1 4 4 4 0 KIP1-like protein TPR_MLP1_2 PF07926.12 ETO03297.1 - 0.00039 20.5 4.6 0.12 12.4 1.1 2.1 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein SKA2 PF16740.5 ETO03297.1 - 0.0095 15.7 2.1 0.0095 15.7 2.1 1.7 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 2 EzrA PF06160.12 ETO03297.1 - 0.0097 14.1 3.2 0.017 13.3 3.2 1.4 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA DUF4200 PF13863.6 ETO03297.1 - 0.016 15.6 7.6 0.15 12.4 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) Microtub_bd PF16796.5 ETO03297.1 - 0.053 13.5 1.8 0.088 12.7 0.2 2.0 2 0 0 2 2 2 0 Microtubule binding Snapin_Pallidin PF14712.6 ETO03297.1 - 0.063 13.7 1.5 0.063 13.7 1.5 2.0 2 1 0 2 2 2 0 Snapin/Pallidin GrpE PF01025.19 ETO03297.1 - 0.081 12.6 2.5 0.1 12.2 2.5 1.2 1 0 0 1 1 1 0 GrpE Spc7 PF08317.11 ETO03297.1 - 0.12 11.3 4.6 0.043 12.7 2.0 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 ETO03297.1 - 0.24 11.6 5.5 0.13 12.5 3.2 1.7 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF1664 PF07889.12 ETO03297.1 - 0.53 10.3 4.0 0.79 9.8 1.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) WD40 PF00400.32 ETO03298.1 - 1.3e-13 51.2 10.4 1.2e-07 32.3 1.5 3.0 2 1 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO03298.1 - 0.00057 19.3 0.4 0.00057 19.3 0.4 1.5 2 0 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO03298.1 - 0.003 16.3 1.4 0.0045 15.7 1.3 1.5 1 1 0 1 1 1 1 Nucleoporin Nup120/160 DUF5520 PF17658.1 ETO03298.1 - 0.0089 15.2 0.5 0.013 14.6 0.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5520) ANAPC4_WD40 PF12894.7 ETO03298.1 - 0.068 13.5 0.3 0.17 12.2 0.1 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Arena_nucleocap PF00843.17 ETO03298.1 - 0.11 11.4 1.2 4.6 6.1 0.6 2.1 2 0 0 2 2 2 0 Arenavirus nucleocapsid N-terminal domain FAM176 PF14851.6 ETO03298.1 - 0.26 10.9 4.8 0.36 10.5 4.8 1.3 1 0 0 1 1 1 0 FAM176 family AATF-Che1 PF13339.6 ETO03298.1 - 0.39 11.4 5.7 0.58 10.8 5.7 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor Gly-zipper_Omp PF13488.6 ETO03299.1 - 1.2e-07 31.6 9.9 5.3e-05 23.1 2.2 2.6 1 1 1 2 2 2 2 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO03299.1 - 0.0049 16.6 1.8 0.37 10.6 1.8 2.9 1 1 0 1 1 1 1 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 ETO03299.1 - 0.14 11.9 1.7 2 8.2 0.3 2.5 1 1 1 2 2 2 0 Glycine-zipper domain RTC PF01137.21 ETO03300.1 - 8.2e-44 149.4 0.0 9.8e-44 149.2 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase FXMRP1_C_core PF12235.8 ETO03300.1 - 0.00098 19.8 3.2 0.0015 19.2 3.2 1.3 1 0 0 1 1 1 1 Fragile X-related 1 protein core C terminal AdoMetDC_leader PF08132.11 ETO03300.1 - 0.0071 16.2 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 S-adenosyl-l-methionine decarboxylase leader peptide Con-6 PF10346.9 ETO03300.1 - 0.19 11.8 1.0 0.34 11.0 1.0 1.4 1 0 0 1 1 1 0 Conidiation protein 6 V-SNARE_C PF12352.8 ETO03301.1 - 3.1e-05 24.2 4.4 3.1e-05 24.2 4.4 2.0 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO03301.1 - 0.00048 20.0 0.3 0.00048 20.0 0.3 2.6 2 1 1 3 3 3 1 Sec20 DUF3829 PF12889.7 ETO03301.1 - 0.017 14.6 2.0 0.023 14.2 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) Nup54_57_C PF18570.1 ETO03301.1 - 0.098 12.3 0.2 0.31 10.7 0.1 1.9 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain DUF2321 PF10083.9 ETO03301.1 - 0.17 11.5 0.8 9.9 5.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2321) TcdB_N PF12918.7 ETO03301.1 - 0.33 11.3 5.1 0.4 11.0 2.8 2.2 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain V-SNARE PF05008.15 ETO03301.1 - 0.94 9.9 7.9 0.046 14.1 1.8 2.1 3 1 0 3 3 3 0 Vesicle transport v-SNARE protein N-terminus Cor1 PF04803.12 ETO03301.1 - 1.7 8.9 8.3 1.2 9.3 1.7 2.7 1 1 2 3 3 3 0 Cor1/Xlr/Xmr conserved region CAP_GLY PF01302.25 ETO03302.1 - 0.086 12.9 0.1 0.17 11.9 0.1 1.7 1 1 0 1 1 1 0 CAP-Gly domain CAP_GLY PF01302.25 ETO03303.1 - 0.017 15.2 1.5 0.75 9.9 0.1 2.8 2 1 0 2 2 2 0 CAP-Gly domain tRNA-synt_2c PF01411.19 ETO03304.1 - 2.9e-05 22.8 0.1 6e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ETO03304.1 - 3.1e-05 24.0 0.7 8.1e-05 22.6 0.1 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain WD40 PF00400.32 ETO03305.1 - 1.3e-35 120.8 27.4 3e-07 31.0 0.3 8.6 7 3 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03305.1 - 3.4e-11 43.3 1.4 0.061 13.6 0.0 4.9 4 3 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03305.1 - 1.7e-07 30.3 4.9 0.09 11.4 0.3 4.7 1 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO03305.1 - 4.9e-05 22.8 6.1 0.0056 16.0 0.4 4.2 2 2 2 5 5 5 2 WD40-like domain SH3_13 PF18335.1 ETO03305.1 - 0.0075 16.1 1.0 0.15 11.9 0.0 3.0 3 0 0 3 3 3 1 ATP-dependent RecD-like DNA helicase SH3 domain Nucleoporin_N PF08801.11 ETO03305.1 - 0.026 13.3 2.3 0.6 8.8 0.4 3.0 3 2 0 3 3 3 0 Nup133 N terminal like FancD2 PF14631.6 ETO03307.1 - 0.018 12.4 0.0 0.022 12.2 0.0 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF2312 PF10073.9 ETO03307.1 - 0.14 11.8 0.0 0.23 11.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) NADH_dh_m_C1 PF15088.6 ETO03308.1 - 0.088 12.4 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial Nop52 PF05997.12 ETO03309.1 - 2.5e-28 99.3 1.3 4.4e-28 98.6 1.3 1.3 1 1 0 1 1 1 1 Nucleolar protein,Nop52 NACHT PF05729.12 ETO03310.1 - 3.8e-10 39.9 0.0 6.8e-10 39.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO03310.1 - 0.00012 22.4 0.9 0.00066 20.0 0.2 2.7 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ETO03310.1 - 0.00012 22.6 0.2 0.0045 17.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain Pneumo_M2 PF07380.11 ETO03310.1 - 0.0028 17.9 5.7 0.18 12.1 0.2 3.3 3 0 0 3 3 3 2 Pneumovirus M2 protein RNA_helicase PF00910.22 ETO03310.1 - 0.016 15.6 2.3 0.072 13.5 0.4 3.0 2 1 0 2 2 2 0 RNA helicase AAA PF00004.29 ETO03310.1 - 0.03 14.7 0.0 0.088 13.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ETO03310.1 - 0.036 14.2 0.0 0.36 11.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain PRK PF00485.18 ETO03310.1 - 0.042 13.6 0.1 0.15 11.8 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_16 PF13191.6 ETO03310.1 - 0.054 13.9 0.1 0.41 11.0 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 ETO03310.1 - 0.086 12.1 0.0 0.17 11.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 ETO03310.1 - 0.11 12.5 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_2 PF03668.15 ETO03310.1 - 0.11 11.8 0.6 0.36 10.1 0.0 2.1 3 0 0 3 3 3 0 P-loop ATPase protein family HEAT PF02985.22 ETO03311.1 - 0.0021 18.2 0.1 0.51 10.7 0.0 3.2 4 0 0 4 4 4 1 HEAT repeat Kelch_1 PF01344.25 ETO03313.1 - 4.6e-07 29.3 0.2 0.0025 17.4 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO03313.1 - 1.5e-06 28.0 0.1 0.01 15.8 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO03313.1 - 6.8e-06 26.0 0.1 0.037 14.0 0.0 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO03313.1 - 2.9e-05 23.9 0.8 0.054 13.5 0.3 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO03313.1 - 0.00016 21.8 2.6 0.075 13.4 0.2 2.6 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO03313.1 - 0.0085 16.4 0.1 0.15 12.4 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain WD40 PF00400.32 ETO03314.1 - 0.051 14.5 0.7 0.48 11.4 0.1 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF2072 PF09845.9 ETO03315.1 - 0.014 15.6 4.7 0.016 15.5 4.7 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein PLA2_B PF01735.18 ETO03315.1 - 0.05 12.0 0.8 0.058 11.8 0.8 1.0 1 0 0 1 1 1 0 Lysophospholipase catalytic domain Syntaxin PF00804.25 ETO03315.1 - 0.12 12.0 12.3 0.12 12.0 12.3 1.1 1 0 0 1 1 1 0 Syntaxin SLED PF12140.8 ETO03315.1 - 0.24 11.9 5.7 0.27 11.7 5.7 1.2 1 0 0 1 1 1 0 SLED domain MMR1 PF08505.10 ETO03315.1 - 0.28 11.4 7.8 0.28 11.4 7.8 1.0 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein RHD_DNA_bind PF00554.22 ETO03315.1 - 0.4 10.6 8.4 0.48 10.3 8.4 1.2 1 0 0 1 1 1 0 Rel homology DNA-binding domain LIN37 PF15306.6 ETO03315.1 - 0.46 10.7 9.7 0.52 10.5 9.7 1.1 1 0 0 1 1 1 0 LIN37 Mgr1 PF08602.10 ETO03315.1 - 0.64 8.8 8.5 0.67 8.7 8.5 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit DUF1943 PF09172.11 ETO03315.1 - 1.4 8.0 11.4 1.6 7.9 11.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) TMPIT PF07851.13 ETO03315.1 - 5.8 6.1 11.8 5.9 6.0 11.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein Connexin PF00029.19 ETO03315.1 - 6.5 6.4 9.4 7.1 6.3 9.4 1.1 1 0 0 1 1 1 0 Connexin DUF1168 PF06658.12 ETO03315.1 - 7.2 6.4 26.8 8 6.3 26.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) WD40 PF00400.32 ETO03316.1 - 7.4e-16 58.3 16.9 5.6e-06 27.0 0.5 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03316.1 - 1.9e-06 28.1 0.8 0.73 10.2 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03316.1 - 1.1e-05 24.3 3.5 0.018 13.7 0.1 3.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 W_rich_C PF07483.11 ETO03316.1 - 0.076 13.2 0.1 0.076 13.2 0.1 3.4 3 1 1 4 4 4 0 Tryptophan-rich Synechocystis species C-terminal domain WD40 PF00400.32 ETO03317.1 - 1.4e-14 54.2 10.4 5.6e-07 30.2 1.4 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03317.1 - 2.4e-05 24.5 0.1 0.001 19.3 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03317.1 - 0.00014 20.7 1.5 0.12 11.0 0.3 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO03317.1 - 0.0078 15.6 1.1 0.011 15.0 1.1 1.3 1 1 0 1 1 1 1 WD40-like domain TetM_leader PF08076.11 ETO03317.1 - 0.31 10.9 1.9 1.4 8.7 0.4 2.4 2 0 0 2 2 2 0 Tetracycline resistance determinant leader peptide DUF3161 PF11362.8 ETO03318.1 - 0.091 12.7 1.0 0.18 11.8 0.4 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3161) TetR_C_27 PF17935.1 ETO03319.1 - 0.038 14.1 0.8 0.045 13.8 0.8 1.2 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Golgin_A5 PF09787.9 ETO03319.1 - 0.11 11.9 16.4 0.052 13.0 14.5 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF2347 PF09804.9 ETO03319.1 - 0.12 11.9 5.9 0.13 11.9 5.1 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) ALMT PF11744.8 ETO03319.1 - 0.15 10.9 8.7 0.17 10.6 8.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Baculo_PEP_C PF04513.12 ETO03319.1 - 0.19 11.8 2.6 0.27 11.3 2.6 1.2 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus RP-C_C PF11800.8 ETO03319.1 - 0.21 11.6 10.5 0.24 11.4 10.5 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region Paf1 PF03985.13 ETO03319.1 - 0.27 10.2 18.6 0.31 10.0 18.6 1.0 1 0 0 1 1 1 0 Paf1 ATP11 PF06644.11 ETO03319.1 - 0.36 10.6 10.1 0.51 10.1 10.1 1.2 1 0 0 1 1 1 0 ATP11 protein CNDH2_C PF16858.5 ETO03319.1 - 0.44 10.4 14.4 0.52 10.1 14.4 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF4746 PF15928.5 ETO03319.1 - 0.51 9.7 18.5 0.59 9.5 18.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF809 PF05663.11 ETO03319.1 - 0.54 10.4 8.3 0.64 10.2 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF809) HAUS6_N PF14661.6 ETO03319.1 - 0.88 9.1 11.5 1.1 8.8 11.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Hox9_act PF04617.13 ETO03319.1 - 1.3 9.8 8.7 1.5 9.6 8.7 1.1 1 0 0 1 1 1 0 Hox9 activation region DUF2457 PF10446.9 ETO03319.1 - 2.4 7.2 22.3 2.7 7.0 22.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 ETO03319.1 - 3.1 7.0 15.6 3.6 6.8 15.6 1.1 1 0 0 1 1 1 0 NOA36 protein Exonuc_VII_L PF02601.15 ETO03319.1 - 3.2 7.2 8.3 3.7 7.0 8.3 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Nop53 PF07767.11 ETO03319.1 - 4.5 6.5 20.5 5.1 6.4 20.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Csm1_N PF18504.1 ETO03319.1 - 5 7.5 19.4 0.93 9.9 14.3 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain RNA_pol_3_Rpc31 PF11705.8 ETO03319.1 - 5.3 7.2 21.8 6.4 7.0 21.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Astro_capsid_p PF12226.8 ETO03319.1 - 8.4 5.4 14.6 9.4 5.3 14.6 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TMPIT PF07851.13 ETO03319.1 - 8.4 5.5 11.8 9.1 5.4 11.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.19 ETO03319.1 - 9.2 4.0 15.5 10 3.9 15.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WD40 PF00400.32 ETO03321.1 - 2.3e-52 173.8 21.3 3.3e-11 43.5 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03321.1 - 1.6e-21 76.4 7.4 0.00024 21.3 0.1 6.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03321.1 - 5e-12 45.4 0.7 0.0022 17.0 0.1 4.9 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO03321.1 - 8.8e-11 42.0 0.6 0.00051 20.0 0.1 3.9 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO03321.1 - 3.4e-07 29.9 0.8 0.00014 21.3 0.3 3.3 2 2 0 2 2 2 1 WD40-like domain PD40 PF07676.12 ETO03321.1 - 1.9e-05 24.5 0.1 6.5 6.8 0.0 5.6 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO03321.1 - 4.4e-05 22.3 3.8 0.012 14.3 0.8 3.4 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO03321.1 - 0.00011 20.8 0.6 0.16 10.4 0.0 3.3 1 1 2 4 4 4 3 Cytochrome D1 heme domain SGL PF08450.12 ETO03321.1 - 0.0019 17.8 0.2 0.016 14.8 0.1 2.2 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region DUF5570 PF17731.1 ETO03321.1 - 0.033 14.3 3.9 4.8 7.3 0.1 3.9 1 1 2 4 4 4 0 Family of unknown function (DUF5570) Gmad1 PF10647.9 ETO03321.1 - 0.047 13.4 0.0 1.6 8.4 0.0 2.5 3 0 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain Utp8 PF10395.9 ETO03321.1 - 0.081 11.4 0.5 0.13 10.7 0.5 1.4 1 0 0 1 1 1 0 Utp8 family Alpha-amyl_C PF09071.10 ETO03321.1 - 0.11 12.4 1.9 16 5.4 0.1 3.6 4 0 0 4 4 4 0 Alpha-amylase, C terminal DUF1264 PF06884.11 ETO03321.1 - 0.14 11.7 1.3 0.8 9.3 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1264) RyR PF02026.16 ETO03321.1 - 0.19 11.9 0.3 0.46 10.7 0.3 1.6 1 0 0 1 1 1 0 RyR domain Resistin PF06954.11 ETO03321.1 - 0.78 10.3 5.1 23 5.6 0.1 4.0 2 2 3 5 5 5 0 Resistin WD40 PF00400.32 ETO03322.1 - 2.2e-33 113.7 21.2 1e-10 42.0 0.3 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03322.1 - 2.3e-18 66.3 3.2 0.00017 21.8 0.1 4.6 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO03322.1 - 5.7e-08 32.9 0.7 0.0029 17.5 0.2 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO03322.1 - 9.6e-07 28.1 1.9 0.0042 16.1 0.1 3.7 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO03322.1 - 1.2e-05 25.1 0.2 3.7 7.6 0.0 4.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO03322.1 - 3.7e-05 23.2 1.1 0.13 11.6 0.2 3.0 1 1 4 5 5 5 4 WD40-like domain Coatomer_WDAD PF04053.14 ETO03322.1 - 0.0056 15.8 2.2 1.6 7.7 0.3 2.4 1 1 0 2 2 2 2 Coatomer WD associated region DUF5570 PF17731.1 ETO03322.1 - 0.0078 16.3 1.5 2.9 8.0 0.1 3.2 1 1 1 3 3 3 1 Family of unknown function (DUF5570) RyR PF02026.16 ETO03322.1 - 0.074 13.2 0.2 0.14 12.4 0.2 1.5 1 0 0 1 1 1 0 RyR domain DUF1264 PF06884.11 ETO03322.1 - 0.077 12.6 0.5 0.69 9.5 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1264) Gmad1 PF10647.9 ETO03322.1 - 0.088 12.5 0.0 5.1 6.8 0.0 2.4 2 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain CN_hydrolase PF00795.22 ETO03322.1 - 0.12 11.7 0.2 0.45 9.8 0.0 2.0 3 0 0 3 3 3 0 Carbon-nitrogen hydrolase PALB2_WD40 PF16756.5 ETO03322.1 - 0.45 9.4 10.6 0.95 8.3 0.2 3.2 2 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF3439 PF11921.8 ETO03323.1 - 0.00034 20.6 5.7 0.00051 20.0 5.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) EB_dh PF09459.10 ETO03323.1 - 0.034 14.1 5.5 0.041 13.9 5.5 1.1 1 0 0 1 1 1 0 Ethylbenzene dehydrogenase Mucin PF01456.17 ETO03323.1 - 0.26 11.3 9.7 0.39 10.7 9.7 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Ndc1_Nup PF09531.10 ETO03323.1 - 1.8 7.1 5.9 2.1 7.0 5.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3435 PF11917.8 ETO03323.1 - 2.7 6.8 16.2 3.2 6.6 16.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) Presenilin PF01080.17 ETO03323.1 - 3.1 6.5 11.0 3.1 6.4 11.0 1.1 1 0 0 1 1 1 0 Presenilin SWI-SNF_Ssr4 PF08549.10 ETO03323.1 - 4.9 5.7 10.2 5.8 5.4 10.2 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) YL1 PF05764.13 ETO03323.1 - 8 6.5 34.6 11 6.1 34.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Otopetrin PF03189.13 ETO03323.1 - 8.4 5.1 7.1 9.8 4.9 7.1 1.1 1 0 0 1 1 1 0 Otopetrin Ribosomal_S19 PF00203.21 ETO03324.1 - 8e-31 105.8 0.9 1.4e-30 105.0 0.9 1.4 1 0 0 1 1 1 1 Ribosomal protein S19 FemAB PF02388.16 ETO03324.1 - 0.25 10.1 2.3 0.34 9.7 2.3 1.1 1 0 0 1 1 1 0 FemAB family 2OG-FeII_Oxy_3 PF13640.6 ETO03325.1 - 3.4e-07 31.1 0.0 1.6e-06 28.9 0.0 2.2 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily EOS1 PF12326.8 ETO03326.1 - 0.0025 17.8 0.1 0.0034 17.3 0.1 1.2 1 0 0 1 1 1 1 N-glycosylation protein DUF3807 PF12720.7 ETO03326.1 - 1.7 8.9 11.5 2.8 8.2 11.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Connexin PF00029.19 ETO03326.1 - 4.3 7.0 7.8 3.2 7.4 5.9 1.7 2 0 0 2 2 2 0 Connexin SR-25 PF10500.9 ETO03326.1 - 5.3 6.6 23.9 8.6 5.9 23.9 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein zf-RanBP PF00641.18 ETO03328.1 - 2.5e-05 23.5 5.6 5e-05 22.5 5.6 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others C1_2 PF03107.16 ETO03328.1 - 2 8.8 5.6 7.2 7.0 2.5 2.8 2 0 0 2 2 2 0 C1 domain Rhabdo_ncap PF00945.18 ETO03329.1 - 0.085 11.7 0.6 0.095 11.6 0.6 1.0 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein GTP_EFTU_D3 PF03143.17 ETO03332.1 - 5.4e-09 36.3 0.0 1.1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D4 PF14578.6 ETO03332.1 - 0.0009 19.1 0.0 0.0022 17.8 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu domain 4 BUD22 PF09073.10 ETO03333.1 - 0.0093 15.4 28.2 0.011 15.1 28.2 1.0 1 0 0 1 1 1 1 BUD22 CDC27 PF09507.10 ETO03333.1 - 0.047 13.1 21.9 0.057 12.8 21.9 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Apt1 PF10351.9 ETO03333.1 - 0.095 11.5 8.4 0.12 11.2 8.4 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Mpp10 PF04006.12 ETO03333.1 - 0.1 11.0 30.3 0.13 10.7 30.3 1.1 1 0 0 1 1 1 0 Mpp10 protein RRN3 PF05327.11 ETO03333.1 - 0.14 10.7 13.5 0.15 10.6 13.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 ETO03333.1 - 0.4 8.8 35.7 0.52 8.5 35.7 1.1 1 0 0 1 1 1 0 Nop14-like family CNDH2_C PF16858.5 ETO03333.1 - 0.79 9.5 18.3 1.2 9.0 18.3 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PI3K_1B_p101 PF10486.9 ETO03333.1 - 1.7 6.3 10.0 2.3 5.9 10.0 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SDA1 PF05285.12 ETO03333.1 - 3 7.2 36.9 4.3 6.7 36.9 1.2 1 0 0 1 1 1 0 SDA1 Macoilin PF09726.9 ETO03333.1 - 3 6.3 14.0 3.8 5.9 14.0 1.1 1 0 0 1 1 1 0 Macoilin family Afi1 PF07792.12 ETO03333.1 - 4.9 7.6 24.7 1.7 9.2 17.5 2.3 1 1 1 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2457 PF10446.9 ETO03333.1 - 8.4 5.4 41.3 14 4.7 41.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2120 PF09893.9 ETO03334.1 - 0.017 15.3 0.1 0.017 15.2 0.1 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) CAF20 PF17052.5 ETO03334.1 - 0.044 13.9 0.1 0.044 13.9 0.1 1.1 1 0 0 1 1 1 0 Cap associated factor Attractin PF08037.11 ETO03334.1 - 0.076 13.0 0.4 0.11 12.5 0.4 1.3 1 0 0 1 1 1 0 Attractin family Tctex-1 PF03645.13 ETO03338.1 - 0.25 11.6 2.1 0.51 10.6 2.1 1.7 1 1 0 1 1 1 0 Tctex-1 family Rhabdo_ncap_2 PF03216.13 ETO03339.1 - 0.01 15.3 0.8 0.013 15.0 0.8 1.2 1 0 0 1 1 1 0 Rhabdovirus nucleoprotein DUF3888 PF13027.6 ETO03339.1 - 0.031 14.7 0.3 0.071 13.5 0.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) Vac_Fusion PF02346.16 ETO03339.1 - 0.05 13.2 1.5 0.26 10.9 1.5 2.3 1 1 0 1 1 1 0 Chordopoxvirus multifunctional envelope protein A27 FAA_hydro_N_2 PF18288.1 ETO03339.1 - 0.055 13.9 0.1 0.29 11.6 0.1 2.1 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 AbiH PF14253.6 ETO03339.1 - 0.07 13.0 8.5 0.11 12.3 8.3 1.5 1 1 0 1 1 1 0 Bacteriophage abortive infection AbiH HRG PF16954.5 ETO03340.1 - 0.19 12.2 3.9 0.16 12.4 1.8 1.8 1 1 1 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene TB2_DP1_HVA22 PF03134.19 ETO03341.1 - 2.8 7.9 0.0 2.8 7.9 0.0 2.7 2 1 1 3 3 3 0 TB2/DP1, HVA22 family HOIP-UBA PF16678.5 ETO03342.1 - 0.0038 17.2 0.2 0.024 14.6 0.1 2.3 2 0 0 2 2 2 1 HOIP UBA domain pair DUF5617 PF18493.1 ETO03342.1 - 0.011 15.9 0.1 0.011 15.9 0.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF5617) Vps51 PF08700.11 ETO03342.1 - 0.27 11.4 5.9 2.6 8.2 0.4 3.5 1 1 2 3 3 3 0 Vps51/Vps67 DNA_ligase_aden PF01653.18 ETO03343.1 - 0.014 14.5 0.1 0.018 14.1 0.1 1.1 1 0 0 1 1 1 0 NAD-dependent DNA ligase adenylation domain DUF536 PF04394.14 ETO03343.1 - 0.03 14.2 2.0 0.073 12.9 2.0 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF536 DEP PF00610.21 ETO03345.1 - 0.0043 17.1 0.6 0.48 10.5 0.0 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SusF_SusE PF16411.5 ETO03345.1 - 0.033 14.7 0.2 0.17 12.4 0.0 1.8 1 1 1 2 2 2 0 Outer membrane protein SusF_SusE GTP_EFTU PF00009.27 ETO03346.1 - 4.8e-20 71.9 0.0 5.3e-20 71.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ETO03346.1 - 0.017 14.6 0.2 0.096 12.1 0.1 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO03346.1 - 0.057 13.5 0.4 0.89 9.7 0.4 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase NIR_SIR_ferr PF03460.17 ETO03346.1 - 0.069 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Nitrite/Sulfite reductase ferredoxin-like half domain RsgA_GTPase PF03193.16 ETO03346.1 - 0.15 12.0 0.3 0.93 9.4 0.1 2.0 1 1 0 2 2 2 0 RsgA GTPase IL3 PF02059.15 ETO03347.1 - 0.048 13.7 2.7 0.053 13.6 0.3 2.0 2 0 0 2 2 2 0 Interleukin-3 NTP_transf_2 PF01909.23 ETO03347.1 - 0.1 12.9 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 Nucleotidyltransferase domain UPF0515 PF15135.6 ETO03348.1 - 0.13 11.6 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 Kelch_2 PF07646.15 ETO03350.1 - 8.5e-06 25.5 0.3 0.00052 19.9 0.1 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO03350.1 - 3.4e-05 23.4 0.1 0.00027 20.5 0.0 2.5 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO03350.1 - 0.00052 20.2 0.4 1.1 9.7 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO03350.1 - 0.0076 16.2 0.1 0.033 14.2 0.0 2.2 2 1 0 2 2 2 1 Galactose oxidase, central domain DUF4518 PF15008.6 ETO03352.1 - 0.025 13.8 0.1 0.028 13.6 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4518) PPC PF04151.15 ETO03352.1 - 1 10.5 6.4 1.6 9.9 6.4 1.3 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain Secretin_N_2 PF07655.13 ETO03352.1 - 3.4 8.3 13.4 8.9 6.9 13.4 1.8 1 1 0 1 1 1 0 Secretin N-terminal domain Fanconi_A PF03511.14 ETO03354.1 - 0.022 14.7 0.1 0.052 13.5 0.0 1.7 2 0 0 2 2 2 0 Fanconi anaemia group A protein Tubulin PF00091.25 ETO03355.1 - 1.7e-23 83.9 0.3 4.7e-23 82.4 0.3 1.7 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO03355.1 - 0.01 15.1 0.0 0.011 15.0 0.0 1.2 1 0 0 1 1 1 0 Tubulin like NAD_binding_6 PF08030.12 ETO03357.1 - 1e-11 45.2 0.0 1.9e-11 44.3 0.0 1.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain RNase_H PF00075.24 ETO03358.1 - 1.4e-10 41.5 0.0 2.3e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 ETO03358.1 - 0.0024 18.5 0.5 0.0057 17.3 0.5 1.6 1 1 0 1 1 1 1 zinc-binding in reverse transcriptase CTK3 PF12243.8 ETO03358.1 - 0.016 15.2 0.3 7.3 6.6 0.0 3.2 2 1 1 3 3 3 0 CTD kinase subunit gamma CTK3 Lipase_GDSL_3 PF14606.6 ETO03358.1 - 0.067 13.3 0.2 0.15 12.1 0.1 1.6 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase family dDENN PF03455.19 ETO03358.1 - 0.11 12.5 0.7 0.21 11.6 0.7 1.4 1 0 0 1 1 1 0 dDENN domain Chal_sti_synt_C PF02797.15 ETO03358.1 - 0.15 12.0 0.0 0.26 11.3 0.0 1.4 1 1 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain tRNA_Me_trans PF03054.16 ETO03359.1 - 1.1e-22 80.3 0.0 1.3e-22 80.1 0.0 1.0 1 0 0 1 1 1 1 tRNA methyl transferase tRNA_Me_trans PF03054.16 ETO03360.1 - 3.9e-43 147.6 0.0 4.9e-43 147.3 0.0 1.1 1 0 0 1 1 1 1 tRNA methyl transferase NAD_synthase PF02540.17 ETO03360.1 - 0.0065 15.6 0.0 0.013 14.6 0.0 1.4 1 1 0 1 1 1 1 NAD synthase Asn_synthase PF00733.21 ETO03360.1 - 0.022 14.4 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Asparagine synthase Ras PF00071.22 ETO03361.1 - 3.3e-33 114.6 2.1 3.9e-33 114.3 2.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO03361.1 - 3.9e-13 49.7 1.5 4.5e-13 49.5 0.3 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO03361.1 - 2e-06 27.4 0.5 2.5e-06 27.1 0.5 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 ETO03361.1 - 0.0093 16.0 0.2 0.012 15.6 0.2 1.2 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain FAD_binding_8 PF08022.12 ETO03362.1 - 0.13 12.4 0.1 0.31 11.1 0.1 1.6 1 0 0 1 1 1 0 FAD-binding domain DUF1117 PF06547.12 ETO03362.1 - 0.16 12.6 0.0 0.46 11.1 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1117) LHH PF14411.6 ETO03363.1 - 0.035 14.3 0.4 0.9 9.8 0.1 2.2 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH COX2 PF00116.20 ETO03363.1 - 0.055 13.3 0.0 0.075 12.9 0.0 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase subunit II, periplasmic domain TPR_12 PF13424.6 ETO03364.1 - 4.5e-09 36.5 0.2 3.3e-06 27.3 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03364.1 - 2.9e-07 30.2 2.8 0.00029 20.8 0.4 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03364.1 - 0.0015 18.4 0.0 0.55 10.2 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03364.1 - 0.02 15.0 2.4 1.8 8.9 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03364.1 - 0.033 14.0 3.5 0.092 12.6 0.6 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat Lipase_GDSL_3 PF14606.6 ETO03364.1 - 0.035 14.2 0.6 3.9 7.6 0.3 2.2 1 1 1 2 2 2 0 GDSL-like Lipase/Acylhydrolase family Fer4_12 PF13353.6 ETO03364.1 - 0.054 13.8 0.3 0.15 12.3 0.0 2.0 2 1 0 2 2 2 0 4Fe-4S single cluster domain DUF2610 PF11020.8 ETO03364.1 - 0.12 12.3 0.4 0.61 10.0 0.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF2610) Cas_DxTHG PF09455.10 ETO03365.1 - 0.016 14.8 0.9 0.018 14.7 0.9 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family DEAD PF00270.29 ETO03366.1 - 1.3e-17 64.2 3.3 6.5e-17 61.9 0.1 2.5 3 0 0 3 3 3 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO03366.1 - 6.3e-05 23.0 0.7 0.00014 21.9 0.0 1.9 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 ETO03366.1 - 0.18 11.1 0.0 0.18 11.1 0.0 1.8 2 0 0 2 2 2 0 SecA DEAD-like domain PUB PF09409.10 ETO03367.1 - 0.019 14.9 1.9 0.07 13.1 1.9 2.0 1 1 0 1 1 1 0 PUB domain DUF936 PF06075.12 ETO03368.1 - 1.9 7.3 31.6 2.6 6.9 31.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) ABC_tran PF00005.27 ETO03369.1 - 5.7e-16 59.3 0.0 1.4e-15 58.0 0.0 1.6 2 0 0 2 2 2 1 ABC transporter ABC_ATPase PF09818.9 ETO03369.1 - 1.8e-05 23.7 0.1 2.1e-05 23.5 0.1 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class SMC_N PF02463.19 ETO03369.1 - 8.8e-05 22.0 0.0 0.0001 21.8 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO03369.1 - 0.00025 21.2 0.7 0.0095 16.2 0.7 2.3 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit Calpain_III PF01067.22 ETO03370.1 - 0.11 12.8 2.7 0.13 12.5 2.7 1.2 1 0 0 1 1 1 0 Calpain large subunit, domain III DUF2570 PF10828.8 ETO03372.1 - 0.037 13.8 2.4 0.04 13.7 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) TPR_12 PF13424.6 ETO03373.1 - 3.3e-80 264.4 17.8 1.2e-21 76.8 0.2 5.0 2 1 5 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03373.1 - 8e-57 187.7 4.9 2.5e-10 39.9 0.1 6.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03373.1 - 1.1e-48 161.1 43.3 3.9e-10 39.1 1.5 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03373.1 - 1.7e-43 143.3 27.0 3.5e-09 36.1 0.2 7.0 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03373.1 - 1.7e-38 127.6 37.9 6.7e-07 29.0 0.7 6.8 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03373.1 - 5.9e-35 116.7 7.2 2.5e-06 27.1 0.0 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03373.1 - 2.2e-19 68.8 51.5 2.5e-07 30.3 0.7 9.4 6 4 4 10 10 10 5 TPR repeat TPR_6 PF13174.6 ETO03373.1 - 6.4e-19 67.3 5.6 0.014 16.0 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03373.1 - 1.1e-17 63.0 28.6 0.00011 22.3 0.8 7.5 6 5 0 6 6 6 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03373.1 - 2.1e-16 60.3 0.0 0.00076 20.1 0.0 5.2 3 2 1 4 4 4 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO03373.1 - 1.5e-14 53.1 10.4 0.0085 15.5 0.0 6.1 6 0 0 6 6 6 5 SHNi-TPR TPR_14 PF13428.6 ETO03373.1 - 1.9e-13 50.0 0.0 2 9.5 0.0 6.1 6 0 0 6 6 6 2 Tetratricopeptide repeat SNAP PF14938.6 ETO03373.1 - 7.5e-13 48.5 4.8 4.2e-06 26.4 1.2 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP HTH_Bact PF18768.1 ETO03373.1 - 7.8e-08 31.8 14.0 0.88 9.2 0.1 6.4 6 0 0 6 6 6 2 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO03373.1 - 3.6e-07 30.2 8.6 0.65 10.0 0.3 5.8 1 1 3 5 5 5 2 Protein of unknown function (DUF627) MIT PF04212.18 ETO03373.1 - 8.2e-06 25.8 31.1 0.01 15.9 1.4 6.1 4 1 3 7 7 7 3 MIT (microtubule interacting and transport) domain Tat PF00539.18 ETO03373.1 - 9.9e-05 22.4 0.0 35 4.6 0.0 5.4 5 0 0 5 5 5 0 Transactivating regulatory protein (Tat) YflT PF11181.8 ETO03373.1 - 0.00012 22.5 3.2 1.5 9.4 0.1 3.5 2 2 1 3 3 3 2 Heat induced stress protein YflT KCNQC3-Ank-G_bd PF11956.8 ETO03373.1 - 0.00013 22.2 0.1 3.4 8.0 0.0 4.5 1 1 4 5 5 5 1 Ankyrin-G binding motif of KCNQ2-3 ATP-synt_D PF01813.17 ETO03373.1 - 0.00018 21.4 0.2 7.1 6.4 0.0 4.4 1 1 4 5 5 5 0 ATP synthase subunit D TPR_19 PF14559.6 ETO03373.1 - 0.00023 21.6 2.0 3.4 8.2 0.1 3.8 2 2 2 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03373.1 - 0.00026 21.1 12.1 0.11 12.8 0.3 3.9 2 1 1 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 UVR PF02151.19 ETO03373.1 - 0.00074 19.2 17.2 4.3 7.2 0.2 5.9 6 0 0 6 6 6 2 UvrB/uvrC motif mit_SMPDase PF14724.6 ETO03373.1 - 0.0011 17.1 2.0 0.31 9.0 0.1 2.8 1 1 2 3 3 3 2 Mitochondrial-associated sphingomyelin phosphodiesterase DUF5113 PF17140.4 ETO03373.1 - 0.0026 17.6 20.0 0.99 9.2 0.2 5.9 4 1 2 6 6 6 1 Domain of unknown function (DUF5113) DUF5475 PF17569.2 ETO03373.1 - 0.0032 17.7 0.0 3.8 7.9 0.0 4.3 1 1 4 5 5 5 1 Family of unknown function (DUF5475) DUF2959 PF11172.8 ETO03373.1 - 0.0051 17.0 2.1 1.2 9.3 0.7 3.3 1 1 3 4 4 4 1 Protein of unknown function (DUF2959) NSF PF02071.20 ETO03373.1 - 0.0066 16.9 13.0 92 4.6 0.1 6.6 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat OEP PF02321.18 ETO03373.1 - 0.04 13.7 13.4 0.3 10.9 0.3 3.9 2 1 3 5 5 5 0 Outer membrane efflux protein TetR_C_19 PF17924.1 ETO03373.1 - 0.083 13.5 9.5 39 4.9 0.1 5.1 5 0 0 5 5 5 0 Tetracyclin repressor-like, C-terminal domain Sel1 PF08238.12 ETO03373.1 - 0.28 11.9 16.3 28 5.6 0.1 6.3 7 0 0 7 7 6 0 Sel1 repeat Sda PF08970.10 ETO03373.1 - 0.7 9.7 13.6 38 4.1 0.1 5.4 6 0 0 6 6 5 0 Sporulation inhibitor A Pedibin PF08182.11 ETO03373.1 - 0.81 9.5 8.7 1.8e+02 2.1 0.0 5.6 7 0 0 7 7 6 0 Pedibin/Hym-346 family ATP-synt_E_2 PF08112.11 ETO03373.1 - 3.9 7.8 13.0 28 5.1 0.0 5.2 6 0 0 6 6 5 0 ATP synthase epsilon subunit SET PF00856.28 ETO03377.1 - 6.1e-05 23.5 0.2 0.00014 22.3 0.2 1.6 1 1 0 1 1 1 1 SET domain Retrotran_gag_3 PF14244.6 ETO03379.1 - 0.1 12.4 0.2 15 5.5 0.0 2.2 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type WD40 PF00400.32 ETO03381.1 - 7.8e-25 86.7 14.2 1.7e-05 25.4 0.6 5.5 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03381.1 - 1.3e-11 44.6 0.4 0.0034 17.7 0.0 4.2 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03381.1 - 4.4e-07 28.9 1.4 1.1 7.8 0.0 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO03381.1 - 0.00042 20.3 0.4 0.91 9.6 0.2 3.4 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO03382.1 - 4e-08 33.8 3.5 5.8e-08 33.3 1.6 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat Vfa1 PF08432.10 ETO03382.1 - 0.015 15.6 5.2 0.02 15.2 5.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FAM76 PF16046.5 ETO03382.1 - 0.017 14.5 11.7 0.022 14.1 11.7 1.1 1 0 0 1 1 1 0 FAM76 protein Geminin PF07412.12 ETO03382.1 - 0.037 13.8 2.8 0.037 13.8 2.8 2.1 1 1 1 2 2 2 0 Geminin DDHD PF02862.17 ETO03382.1 - 0.083 13.0 2.5 0.11 12.7 2.5 1.1 1 0 0 1 1 1 0 DDHD domain DUF16 PF01519.16 ETO03382.1 - 0.47 11.0 15.4 0.43 11.1 14.2 1.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 Atg14 PF10186.9 ETO03382.1 - 0.5 9.4 10.6 0.56 9.2 10.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MCM PF00493.23 ETO03383.1 - 0.00074 18.7 0.1 0.0012 18.0 0.1 1.4 1 1 0 1 1 1 1 MCM P-loop domain AAA PF00004.29 ETO03383.1 - 0.005 17.3 0.2 0.29 11.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Microtub_bd PF16796.5 ETO03383.1 - 0.0084 16.0 0.1 0.0088 16.0 0.1 1.3 1 0 0 1 1 1 1 Microtubule binding DUF815 PF05673.13 ETO03383.1 - 0.011 15.0 0.0 0.012 14.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 ETO03383.1 - 0.058 13.7 0.2 0.17 12.1 0.1 1.9 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO03383.1 - 0.077 13.5 0.1 0.14 12.7 0.1 1.4 1 0 0 1 1 1 0 ABC transporter ResIII PF04851.15 ETO03383.1 - 0.12 12.4 0.3 0.16 12.0 0.3 1.4 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit PhoH PF02562.16 ETO03383.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein Plasmodium_Vir PF05795.11 ETO03385.1 - 0.016 14.7 20.1 0.018 14.5 20.1 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CDC45 PF02724.14 ETO03385.1 - 0.5 8.6 27.6 0.52 8.5 27.6 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO03385.1 - 0.73 9.6 26.4 0.91 9.3 26.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 ETO03385.1 - 2.2 8.4 14.2 2.9 8.0 14.2 1.2 1 0 0 1 1 1 0 DDHD domain MDM1 PF15501.6 ETO03385.1 - 3 6.9 30.3 3.3 6.8 30.3 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 Paf1 PF03985.13 ETO03385.1 - 3.2 6.6 32.8 4 6.3 32.8 1.1 1 0 0 1 1 1 0 Paf1 Endostatin PF06482.11 ETO03385.1 - 3.6 6.9 12.3 4.3 6.7 12.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin RRN3 PF05327.11 ETO03385.1 - 5.3 5.5 14.6 6.4 5.2 14.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 AAA_11 PF13086.6 ETO03385.1 - 6.4 6.5 21.1 8.1 6.1 21.1 1.1 1 0 0 1 1 1 0 AAA domain DUF1682 PF07946.14 ETO03385.1 - 6.7 5.8 31.5 8 5.6 31.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Serinc PF03348.15 ETO03385.1 - 7.7 5.3 9.0 9.5 5.0 9.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4746 PF15928.5 ETO03385.1 - 7.9 5.8 22.7 9.9 5.5 22.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Rtf2 PF04641.12 ETO03385.1 - 8.5 5.7 24.4 11 5.3 24.4 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger PBP_sp32 PF07222.12 ETO03385.1 - 9.5 5.6 20.7 12 5.3 20.7 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Kelch_4 PF13418.6 ETO03386.1 - 0.017 15.2 0.2 3.7 7.6 0.1 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF2107 PF09880.9 ETO03387.1 - 0.095 12.8 0.1 0.15 12.2 0.1 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2107) DUF4139 PF13598.6 ETO03387.1 - 0.28 10.9 4.1 5.1 6.8 4.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4139) Pkinase PF00069.25 ETO03389.1 - 9.1e-09 35.1 0.0 1.6e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03389.1 - 0.00042 19.7 0.0 0.0008 18.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kelch_2 PF07646.15 ETO03391.1 - 0.0032 17.4 0.9 0.021 14.8 0.4 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO03391.1 - 0.01 15.8 0.5 1 9.4 0.1 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03391.1 - 0.018 14.6 0.5 0.13 11.9 0.2 2.5 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO03391.1 - 0.057 13.7 0.1 0.66 10.4 0.0 2.9 2 0 0 2 2 2 0 Kelch motif DUF987 PF06174.11 ETO03391.1 - 0.12 12.3 0.0 0.37 10.7 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF987) WD40 PF00400.32 ETO03392.1 - 8.2e-14 51.8 5.4 3.4e-07 30.8 0.9 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO03392.1 - 9e-05 21.3 0.8 0.001 17.8 0.2 2.2 1 1 1 2 2 2 1 Nucleoporin Nup120/160 AIP3 PF03915.13 ETO03392.1 - 0.0095 15.1 14.7 0.012 14.7 14.7 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 DUF4525 PF15027.6 ETO03392.1 - 0.0097 15.6 0.2 0.0097 15.6 0.2 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4525) ANAPC4_WD40 PF12894.7 ETO03392.1 - 0.012 15.9 0.1 0.089 13.1 0.0 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain FlhE PF06366.13 ETO03393.1 - 0.055 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Flagellar protein FlhE RIG-I_C-RD PF11648.8 ETO03393.1 - 0.17 12.1 2.8 3.3 7.9 0.1 2.3 2 0 0 2 2 2 0 C-terminal domain of RIG-I DUF1007 PF06226.13 ETO03393.1 - 1.2 9.1 4.4 4.8 7.1 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1007) GSH_synth_ATP PF03917.17 ETO03394.1 - 0.012 14.4 0.2 0.015 14.1 0.2 1.1 1 0 0 1 1 1 0 Eukaryotic glutathione synthase, ATP binding domain DUF3713 PF12506.8 ETO03394.1 - 0.052 13.8 1.5 0.92 9.8 1.5 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3713) Ank_2 PF12796.7 ETO03395.1 - 0.0033 18.0 0.1 0.0053 17.3 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO03395.1 - 0.015 15.8 0.3 0.062 13.9 0.1 2.0 3 0 0 3 3 3 0 Ankyrin repeats (many copies) DUF2208 PF09973.9 ETO03397.1 - 0.023 14.3 0.6 0.028 14.0 0.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Phage_sheath_1 PF04984.14 ETO03397.1 - 0.1 12.5 0.1 5.4 6.8 0.0 2.1 2 0 0 2 2 2 0 Phage tail sheath protein subtilisin-like domain DUF5341 PF17276.2 ETO03397.1 - 0.12 12.5 2.8 1.4 9.1 0.5 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5341) PUF PF00806.19 ETO03398.1 - 0.032 13.9 0.0 2.5 7.9 0.0 2.9 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat NLRC4_HD2 PF17776.1 ETO03399.1 - 0.025 15.1 0.2 0.025 15.1 0.2 2.7 2 1 1 3 3 3 0 NLRC4 helical domain HD2 Kelch_6 PF13964.6 ETO03400.1 - 2e-09 37.4 0.3 7.9e-06 26.0 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO03400.1 - 4.6e-07 29.3 0.1 6.7e-05 22.4 0.1 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO03400.1 - 0.00011 22.1 1.1 0.0061 16.5 0.0 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO03400.1 - 0.001 19.0 0.7 0.09 12.8 0.2 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO03400.1 - 0.001 19.3 0.1 0.034 14.4 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain TMCO5 PF14992.6 ETO03400.1 - 0.034 13.7 4.7 0.062 12.9 4.7 1.3 1 0 0 1 1 1 0 TMCO5 family Csm1_N PF18504.1 ETO03400.1 - 0.31 11.4 4.7 0.72 10.2 4.7 1.6 1 0 0 1 1 1 0 Csm1 N-terminal domain Rtt102p PF09510.10 ETO03400.1 - 5.5 7.2 7.2 2.5 8.3 3.4 2.4 2 1 0 2 2 2 0 Rtt102p-like transcription regulator protein DUF948 PF06103.11 ETO03400.1 - 9.1 6.6 5.8 9 6.6 3.8 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) PH_12 PF16457.5 ETO03401.1 - 0.017 15.6 0.6 0.079 13.5 0.1 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain TLD PF07534.16 ETO03404.1 - 5.8e-21 75.2 2.0 1.5e-20 73.9 2.0 1.7 1 0 0 1 1 1 1 TLD NPV_P10 PF05531.12 ETO03404.1 - 0.0016 18.8 1.9 0.0016 18.8 1.9 2.5 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein PhaP_Bmeg PF09602.10 ETO03404.1 - 0.0037 17.2 13.9 0.0037 17.2 13.9 2.5 3 0 0 3 3 3 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Tox-ODYAM1 PF15642.6 ETO03404.1 - 0.022 13.8 9.6 0.034 13.1 9.6 1.3 1 0 0 1 1 1 0 Toxin in Odyssella and Amoebophilus HhH-GPD PF00730.25 ETO03404.1 - 0.12 12.8 0.6 0.47 10.9 0.6 2.1 1 1 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein PSII_Pbs27 PF13326.6 ETO03404.1 - 0.97 9.8 5.6 3.1 8.1 5.4 1.7 1 1 0 1 1 1 0 Photosystem II Pbs27 DUF4407 PF14362.6 ETO03404.1 - 1.4 8.2 8.9 0.11 11.8 4.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) YojJ PF10372.9 ETO03404.1 - 6.7 6.9 9.6 2.1 8.5 5.2 2.5 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus PPR_3 PF13812.6 ETO03405.1 - 3.8e-13 49.3 0.4 4.6e-05 23.4 0.0 3.4 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO03405.1 - 1e-12 48.0 1.1 3.5e-10 39.9 0.2 3.0 2 1 1 3 3 3 2 PPR repeat family PPR_1 PF12854.7 ETO03405.1 - 2.3e-12 46.4 0.5 1.3e-05 24.8 0.0 3.4 3 0 0 3 3 3 3 PPR repeat PPR PF01535.20 ETO03405.1 - 1.7e-11 43.6 1.6 2.6e-06 27.3 0.0 3.0 4 0 0 4 4 4 2 PPR repeat PPR_long PF17177.4 ETO03405.1 - 0.0055 16.1 0.0 0.0072 15.7 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO03405.1 - 0.033 14.1 0.4 0.12 12.2 0.1 2.2 1 1 1 2 2 2 0 Mitochondrial ATPase expression APOBEC_N PF08210.11 ETO03405.1 - 0.086 12.7 0.6 0.11 12.3 0.6 1.2 1 0 0 1 1 1 0 APOBEC-like N-terminal domain CDC27 PF09507.10 ETO03407.1 - 3.6 6.9 27.6 4.7 6.5 27.6 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 APG12 PF04110.13 ETO03409.1 - 0.089 13.2 0.7 1.3 9.4 0.0 2.2 2 0 0 2 2 2 0 Ubiquitin-like autophagy protein Apg12 DrsE_2 PF13686.6 ETO03409.1 - 0.43 10.5 3.2 0.2 11.6 0.8 1.6 2 0 0 2 2 2 0 DsrE/DsrF/DrsH-like family TPR_22 PF18833.1 ETO03410.1 - 0.033 14.3 1.4 0.047 13.8 0.8 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat DUF3413 PF11893.8 ETO03411.1 - 0.039 13.1 4.9 0.069 12.3 4.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) Cnd1 PF12717.7 ETO03412.1 - 0.015 15.3 0.4 0.025 14.6 0.3 1.4 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO03415.1 - 0.0001 22.7 0.0 2.5 8.7 0.0 3.0 3 0 0 3 3 3 2 HEAT-like repeat HEAT PF02985.22 ETO03415.1 - 0.0016 18.5 0.0 12 6.4 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO03415.1 - 0.017 15.5 0.0 1.4 9.4 0.0 2.1 2 0 0 2 2 2 0 HEAT repeats CLASP_N PF12348.8 ETO03415.1 - 0.094 12.3 0.0 0.13 11.8 0.0 1.3 1 1 0 1 1 1 0 CLASP N terminal rve PF00665.26 ETO03417.1 - 9.7e-14 51.6 0.0 2e-13 50.6 0.0 1.5 2 0 0 2 2 2 1 Integrase core domain rve_3 PF13683.6 ETO03417.1 - 0.011 15.5 0.0 0.026 14.3 0.0 1.7 1 0 0 1 1 1 0 Integrase core domain Pkinase PF00069.25 ETO03418.1 - 2.3e-07 30.5 1.0 5.3e-07 29.3 0.7 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03418.1 - 2.4e-05 23.8 2.1 4.5e-05 22.9 2.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase DUF3949 PF13133.6 ETO03419.1 - 0.36 11.3 0.2 0.36 11.3 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3949) Ldh_1_N PF00056.23 ETO03420.1 - 1.5e-21 77.0 0.3 1.2e-20 74.0 0.3 1.9 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain zf-TRAF PF02176.18 ETO03422.1 - 4.1e-05 24.2 4.9 4.1e-05 24.2 4.9 2.7 3 1 0 3 3 3 1 TRAF-type zinc finger Cyto_heme_lyase PF01265.17 ETO03422.1 - 0.54 9.8 7.4 0.3 10.7 5.7 1.4 1 1 0 1 1 1 0 Cytochrome c/c1 heme lyase RVT_1 PF00078.27 ETO03423.1 - 2.6e-14 53.3 0.3 5.9e-13 48.9 0.2 2.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5542 PF17696.1 ETO03424.1 - 0.19 11.9 0.6 0.55 10.4 0.0 2.0 3 0 0 3 3 3 0 Family of unknown function (DUF5542) TPR_12 PF13424.6 ETO03425.1 - 4.2e-36 123.1 1.0 1.7e-20 73.1 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03425.1 - 7.1e-35 117.9 0.0 2.5e-10 39.9 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03425.1 - 3.4e-24 83.6 17.3 7.2e-09 35.1 0.3 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03425.1 - 7.8e-23 78.8 1.6 7.2e-08 31.9 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03425.1 - 3.2e-19 67.5 19.9 9e-09 34.9 0.8 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03425.1 - 6.5e-19 66.5 12.5 3e-06 26.9 0.1 3.8 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03425.1 - 9.5e-11 41.3 4.5 0.00068 19.8 0.1 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03425.1 - 9.6e-11 42.2 0.0 0.0011 19.5 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03425.1 - 2e-08 34.4 3.3 0.2 12.3 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03425.1 - 1.5e-06 28.5 0.0 2.7 9.0 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03425.1 - 0.00016 21.3 27.7 0.0069 16.0 4.6 5.9 3 2 3 6 6 6 3 TPR repeat SNAP PF14938.6 ETO03425.1 - 0.0003 20.3 1.2 0.00091 18.7 1.2 1.7 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO03425.1 - 0.00056 19.8 5.4 1 9.2 0.1 3.5 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO03425.1 - 0.00077 19.4 19.2 0.098 12.7 0.9 4.1 4 0 0 4 4 3 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03425.1 - 0.001 19.2 2.5 0.33 11.2 0.1 2.8 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO03425.1 - 0.002 18.6 0.4 0.025 15.1 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO03425.1 - 0.007 15.8 0.0 0.012 15.1 0.0 1.4 1 0 0 1 1 1 1 MalT-like TPR region MIT PF04212.18 ETO03425.1 - 0.021 14.9 12.7 0.2 11.7 0.3 3.5 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO03425.1 - 0.069 13.4 10.1 0.16 12.3 0.1 4.5 5 0 0 5 5 4 0 PPR repeat PcfK PF14058.6 ETO03425.1 - 0.1 12.8 0.3 0.1 12.8 0.3 2.8 2 1 0 2 2 2 0 PcfK-like protein RPN7 PF10602.9 ETO03425.1 - 0.14 11.9 3.6 7.7 6.2 0.2 2.8 1 1 2 3 3 3 0 26S proteasome subunit RPN7 DUF627 PF04781.12 ETO03425.1 - 0.17 11.9 1.0 19 5.3 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF627) HTH_Bact PF18768.1 ETO03425.1 - 0.2 11.3 6.6 21 4.8 0.1 4.1 3 1 1 4 4 4 0 Helix-turn-helix bacterial domain DUF4810 PF16068.5 ETO03425.1 - 0.98 10.0 5.9 46 4.7 0.5 3.6 3 1 1 4 4 3 0 Domain of unknown function (DUF4810) Sel1 PF08238.12 ETO03425.1 - 2.6 8.8 6.1 6.1 7.7 0.1 3.1 3 0 0 3 3 2 0 Sel1 repeat DUF1451 PF07295.11 ETO03426.1 - 0.043 13.8 0.1 0.22 11.5 0.0 2.2 3 0 0 3 3 3 0 Zinc-ribbon containing domain NACHT PF05729.12 ETO03427.1 - 4.4e-19 69.0 0.0 1.2e-18 67.5 0.0 1.8 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO03427.1 - 0.00014 21.2 0.1 0.00031 20.0 0.1 1.6 1 0 0 1 1 1 1 NB-ARC domain Mg_chelatase PF01078.21 ETO03427.1 - 0.088 12.2 0.0 0.55 9.6 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ETO03427.1 - 0.12 12.8 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain NLRC4_HD2 PF17776.1 ETO03427.1 - 0.2 12.2 3.7 0.35 11.4 0.0 3.3 4 0 0 4 4 4 0 NLRC4 helical domain HD2 HEAT PF02985.22 ETO03428.1 - 5.1e-15 54.3 0.5 0.09 13.1 0.0 8.4 8 0 0 8 8 8 4 HEAT repeat HEAT_2 PF13646.6 ETO03428.1 - 3.4e-11 43.4 0.0 0.028 14.8 0.0 5.4 3 2 3 6 6 6 2 HEAT repeats Cnd1 PF12717.7 ETO03428.1 - 5.2e-06 26.6 20.8 2e-05 24.7 6.8 4.0 2 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETO03428.1 - 1.6e-05 25.0 10.6 0.26 11.5 0.2 4.9 3 1 0 4 4 4 3 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_EZ PF13513.6 ETO03428.1 - 5.1e-05 23.7 0.0 1.1e+02 3.4 0.0 6.2 6 1 1 7 7 7 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO03428.1 - 0.0095 16.5 5.5 0.22 12.1 0.2 4.2 3 2 1 4 4 4 1 Vacuolar 14 Fab1-binding region Ank_3 PF13606.6 ETO03429.1 - 0.0052 17.2 0.0 0.029 14.9 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat DNA_pol_E_B PF04042.16 ETO03429.1 - 0.03 13.7 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B Smg8_Smg9 PF10220.9 ETO03431.1 - 0.00011 20.8 11.8 0.00013 20.5 11.8 1.0 1 0 0 1 1 1 1 Smg8_Smg9 Apt1 PF10351.9 ETO03431.1 - 0.077 11.8 17.4 0.072 11.9 17.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Transformer PF06495.11 ETO03431.1 - 0.16 12.1 11.9 0.22 11.6 11.9 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein RPOL_N PF14700.6 ETO03431.1 - 0.41 10.0 14.9 0.45 9.9 14.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal SLC12 PF03522.15 ETO03431.1 - 0.99 8.4 21.3 1.1 8.3 21.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Otopetrin PF03189.13 ETO03431.1 - 2.1 7.0 5.5 2.5 6.8 5.5 1.1 1 0 0 1 1 1 0 Otopetrin NPR3 PF03666.13 ETO03431.1 - 3.1 6.5 30.1 3.4 6.4 30.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PI3K_1B_p101 PF10486.9 ETO03431.1 - 3.9 5.1 14.6 3.8 5.2 14.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Raftlin PF15250.6 ETO03431.1 - 5.3 5.7 16.4 6 5.5 16.4 1.0 1 0 0 1 1 1 0 Raftlin DUF5094 PF17015.5 ETO03431.1 - 6.3 6.9 29.2 7.7 6.6 29.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) RR_TM4-6 PF06459.12 ETO03431.1 - 7.8 6.2 28.8 9.2 6.0 28.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 ETO03431.1 - 8.1 5.9 29.6 10 5.5 29.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 WD40 PF00400.32 ETO03433.1 - 8.6e-16 58.1 0.4 6e-10 39.6 0.1 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO03433.1 - 4.8e-10 38.9 7.0 2e-06 27.3 0.7 1.8 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) ANAPC4_WD40 PF12894.7 ETO03433.1 - 0.00011 22.4 0.0 0.00056 20.2 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide_4 PF13599.6 ETO03433.1 - 0.0053 16.9 2.9 0.01 16.0 2.0 2.0 1 1 1 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO03433.1 - 0.019 15.1 1.6 0.05 13.8 1.6 1.8 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF3379 PF11859.8 ETO03433.1 - 0.058 12.7 0.1 0.08 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) SesA PF17107.5 ETO03434.1 - 0.076 13.2 0.1 0.099 12.8 0.1 1.3 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Chlor_dismutase PF06778.12 ETO03436.1 - 0.047 13.3 0.8 0.078 12.6 0.8 1.3 1 0 0 1 1 1 0 Chlorite dismutase Menin PF05053.13 ETO03436.1 - 3.9 5.7 18.4 5 5.4 18.4 1.1 1 0 0 1 1 1 0 Menin TPR_MLP1_2 PF07926.12 ETO03440.1 - 0.00086 19.4 32.0 0.038 14.0 8.8 3.0 1 1 2 3 3 3 2 TPR/MLP1/MLP2-like protein APG6_N PF17675.1 ETO03440.1 - 0.0026 18.3 31.1 0.23 12.0 15.8 3.1 1 1 1 2 2 2 2 Apg6 coiled-coil region DUF4200 PF13863.6 ETO03440.1 - 0.011 16.1 19.4 0.011 16.1 19.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) DUF3450 PF11932.8 ETO03440.1 - 0.021 14.2 26.7 0.065 12.5 10.7 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF948 PF06103.11 ETO03440.1 - 0.023 14.9 2.3 0.023 14.9 2.3 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) GAS PF13851.6 ETO03440.1 - 0.024 14.0 35.1 0.26 10.6 16.2 2.4 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Rootletin PF15035.6 ETO03440.1 - 0.027 14.5 23.8 0.034 14.2 23.8 1.1 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF4407 PF14362.6 ETO03440.1 - 0.046 13.1 16.0 0.036 13.4 14.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CENP-F_leu_zip PF10473.9 ETO03440.1 - 0.056 13.5 31.7 2.1 8.4 8.1 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3584 PF12128.8 ETO03440.1 - 0.058 10.9 22.5 0.068 10.7 22.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MAD PF05557.13 ETO03440.1 - 0.072 11.4 25.8 0.12 10.7 25.8 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein ATG16 PF08614.11 ETO03440.1 - 0.14 12.4 30.6 1 9.6 15.1 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SHE3 PF17078.5 ETO03440.1 - 0.16 11.7 31.4 2.9 7.5 12.8 2.3 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Sugarporin_N PF11471.8 ETO03440.1 - 0.19 11.7 0.1 0.19 11.7 0.1 1.9 2 0 0 2 2 1 0 Maltoporin periplasmic N-terminal extension Filament PF00038.21 ETO03440.1 - 0.23 11.0 26.1 0.73 9.4 25.8 1.7 1 1 0 1 1 1 0 Intermediate filament protein Spc7 PF08317.11 ETO03440.1 - 0.29 10.0 30.9 0.69 8.7 7.3 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein ABC_tran_CTD PF16326.5 ETO03440.1 - 0.35 11.1 17.8 0.34 11.2 2.3 3.2 1 1 1 3 3 3 0 ABC transporter C-terminal domain Mito_fiss_reg PF05308.11 ETO03440.1 - 0.58 10.2 11.9 1 9.4 11.9 1.5 1 1 0 1 1 1 0 Mitochondrial fission regulator DUF489 PF04356.12 ETO03440.1 - 1.5 8.8 11.9 5.3 7.0 4.8 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF489) FapA PF03961.13 ETO03440.1 - 1.9 7.0 29.1 0.19 10.3 15.2 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF5082 PF16888.5 ETO03440.1 - 2 8.7 26.3 0.5 10.7 6.0 3.2 1 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF812 PF05667.11 ETO03440.1 - 2 7.2 30.6 7.7 5.3 30.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) CALCOCO1 PF07888.11 ETO03440.1 - 2.3 7.0 25.0 4.5 6.0 25.0 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.22 ETO03440.1 - 2.9 8.2 25.7 0.56 10.4 13.2 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain KELK PF15796.5 ETO03440.1 - 2.9 8.4 27.7 1.2 9.7 13.3 3.1 1 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Ax_dynein_light PF10211.9 ETO03440.1 - 3.2 7.7 32.9 3.3 7.6 17.3 2.8 1 1 2 3 3 3 0 Axonemal dynein light chain DUF2968 PF11180.8 ETO03440.1 - 4.4 6.9 21.9 21 4.7 9.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) PRKG1_interact PF15898.5 ETO03440.1 - 4.5 8.2 29.2 0.8 10.6 13.5 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain ADIP PF11559.8 ETO03440.1 - 4.7 7.3 33.5 2.5 8.2 8.9 3.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SecD-TM1 PF13721.6 ETO03440.1 - 5.2 7.6 9.7 2.8 8.5 1.3 2.5 1 1 1 2 2 2 0 SecD export protein N-terminal TM region DUF848 PF05852.11 ETO03440.1 - 6.8 6.8 18.7 1.4 9.0 2.1 2.4 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Golgin_A5 PF09787.9 ETO03440.1 - 7.1 6.0 28.0 6.7 6.1 20.1 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 BST2 PF16716.5 ETO03440.1 - 7.5 7.2 31.2 7.6 7.2 16.7 2.4 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 TMPIT PF07851.13 ETO03440.1 - 7.8 5.6 28.5 3.1 7.0 13.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein CENP-H PF05837.12 ETO03440.1 - 7.8 6.9 27.7 0.35 11.3 13.1 2.6 1 1 1 2 2 2 0 Centromere protein H (CENP-H) MIEAP PF16026.5 ETO03441.1 - 0.00099 19.4 2.9 0.007 16.6 2.9 2.3 1 1 0 1 1 1 1 Mitochondria-eating protein DUF5083 PF16890.5 ETO03441.1 - 0.11 12.2 0.1 0.17 11.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5083) SpoIIIAH PF12685.7 ETO03442.1 - 3.9 7.3 17.6 6 6.6 17.6 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein U-box PF04564.15 ETO03443.1 - 4.4e-14 52.4 0.1 1.3e-13 50.9 0.1 1.8 1 1 0 1 1 1 1 U-box domain MotCF PF09158.10 ETO03443.1 - 0.031 14.3 1.9 2.6 8.1 0.3 2.2 2 0 0 2 2 2 0 Bacteriophage T4 MotA, C-terminal zf-NOSIP PF15906.5 ETO03443.1 - 0.081 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TPR_12 PF13424.6 ETO03446.1 - 1.5e-24 86.1 2.1 1.2e-15 57.6 0.3 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03446.1 - 1.5e-18 65.8 12.8 2.4e-06 27.1 0.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03446.1 - 2.1e-15 56.0 0.1 1.2e-05 25.0 0.0 3.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03446.1 - 2.3e-15 55.4 9.5 1.2e-06 28.2 1.7 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03446.1 - 1.4e-13 49.9 12.3 1.6e-05 24.8 0.1 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03446.1 - 5.6e-13 47.9 1.0 0.0017 18.3 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO03446.1 - 2.5e-08 33.2 0.1 0.0003 20.2 0.0 3.1 3 0 0 3 3 3 1 SHNi-TPR TPR_11 PF13414.6 ETO03446.1 - 7.8e-08 31.9 17.3 0.012 15.3 3.4 4.4 3 2 2 5 5 5 4 TPR repeat TPR_6 PF13174.6 ETO03446.1 - 1e-06 29.0 1.6 0.012 16.1 0.4 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03446.1 - 1.1e-06 28.6 2.7 0.033 14.6 0.2 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03446.1 - 1.3e-06 28.9 0.0 0.14 12.8 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03446.1 - 0.00035 21.2 0.0 1.7 9.6 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.6 ETO03446.1 - 0.0095 15.4 0.6 0.016 14.6 0.6 1.4 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 ETO03446.1 - 0.015 15.5 1.8 0.13 12.5 0.5 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO03446.1 - 0.021 15.3 0.1 1.5 9.4 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Flavodoxin_1 PF00258.25 ETO03446.1 - 0.082 13.1 0.1 0.32 11.2 0.1 1.8 1 1 0 1 1 1 0 Flavodoxin DUF3856 PF12968.7 ETO03446.1 - 0.096 12.8 0.4 1.4 9.0 0.1 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) DUF1120 PF06551.12 ETO03446.1 - 0.15 12.2 0.0 19 5.4 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1120) Inhibitor_I29 PF08246.12 ETO03446.1 - 0.52 10.8 3.6 3 8.3 0.1 2.8 2 1 0 2 2 2 0 Cathepsin propeptide inhibitor domain (I29) UVR PF02151.19 ETO03446.1 - 1.2 9.0 5.2 1.4 8.8 0.3 3.1 3 1 1 4 4 4 0 UvrB/uvrC motif Sel1 PF08238.12 ETO03446.1 - 3.4 8.5 6.9 23 5.9 0.0 3.3 3 1 0 3 3 3 0 Sel1 repeat WD40 PF00400.32 ETO03447.1 - 4.3e-32 109.7 21.2 3.6e-05 24.4 0.5 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03447.1 - 3.9e-09 36.7 0.2 0.048 14.0 0.0 4.2 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03447.1 - 8e-07 28.1 4.7 0.82 8.2 0.0 4.9 1 1 3 5 5 5 5 Nucleoporin Nup120/160 WD40 PF00400.32 ETO03448.1 - 6.4e-78 254.7 40.2 4.9e-08 33.5 0.1 10.3 10 0 0 10 10 10 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03448.1 - 2.6e-17 62.9 8.8 0.029 14.7 0.1 8.3 1 1 7 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03448.1 - 4e-14 52.7 13.2 2e-05 24.1 0.3 4.9 1 1 4 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 ETO03448.1 - 2.9e-13 49.5 5.3 0.25 10.3 0.0 7.2 1 1 7 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO03448.1 - 3.1e-08 32.7 18.3 0.34 9.5 0.0 8.3 2 1 6 9 9 9 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO03448.1 - 1.2e-07 31.8 2.5 0.0024 17.8 0.1 4.9 1 1 2 5 5 5 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO03448.1 - 7.4e-05 22.6 19.1 4.6 7.3 0.2 7.6 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETO03448.1 - 0.00013 20.5 2.0 0.36 9.1 0.0 3.9 3 1 1 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz HARP PF07443.13 ETO03448.1 - 0.00039 20.0 0.0 10 5.8 0.0 5.2 6 0 0 6 6 6 1 HepA-related protein (HARP) RE_XamI PF09572.10 ETO03448.1 - 0.0065 16.2 0.0 3.6 7.2 0.0 3.8 3 2 1 4 4 4 1 XamI restriction endonuclease Cytochrom_D1 PF02239.16 ETO03448.1 - 0.02 13.5 1.7 0.31 9.5 0.1 3.3 1 1 1 3 3 3 0 Cytochrome D1 heme domain POLO_box PF00659.18 ETO03448.1 - 0.027 14.7 8.8 20 5.5 0.1 6.8 8 0 0 8 8 8 0 POLO box duplicated region TolB_N PF04052.13 ETO03448.1 - 0.052 13.7 0.0 80 3.5 0.0 5.0 6 0 0 6 6 6 0 TolB amino-terminal domain Mid2 PF04478.12 ETO03448.1 - 0.056 13.3 0.4 2 8.2 0.0 3.4 3 0 0 3 3 3 0 Mid2 like cell wall stress sensor Resistin PF06954.11 ETO03448.1 - 0.22 12.1 0.8 44 4.7 0.0 4.3 5 1 0 5 5 5 0 Resistin Kelch_6 PF13964.6 ETO03449.1 - 4.1e-05 23.7 1.2 0.0017 18.6 0.1 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO03449.1 - 0.0003 20.7 0.1 0.038 14.0 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO03449.1 - 0.0047 16.5 0.2 0.12 12.0 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO03449.1 - 0.12 12.3 0.1 2 8.5 0.0 2.6 2 0 0 2 2 2 0 Kelch motif YABBY PF04690.13 ETO03450.1 - 0.027 15.0 0.3 0.031 14.8 0.3 1.1 1 0 0 1 1 1 0 YABBY protein DUF4834 PF16118.5 ETO03450.1 - 0.33 11.9 2.4 0.64 11.0 2.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) PPR_2 PF13041.6 ETO03452.1 - 0.0013 18.9 0.1 0.0024 18.0 0.1 1.4 1 0 0 1 1 1 1 PPR repeat family DUF2709 PF10915.8 ETO03452.1 - 0.033 13.5 0.4 0.041 13.2 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2709) PPR PF01535.20 ETO03452.1 - 0.049 13.9 0.1 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 PPR repeat FAA_hydrolase PF01557.18 ETO03453.1 - 7.6e-33 114.0 0.0 8.6e-33 113.8 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family tRNA-synt_1c PF00749.21 ETO03454.1 - 6.5e-35 120.5 0.0 6.5e-35 120.5 0.0 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain Vfa1 PF08432.10 ETO03454.1 - 1.8 8.9 10.3 2.4 8.4 10.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 MAJIN PF15077.6 ETO03455.1 - 0.041 13.7 3.3 0.049 13.4 3.3 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein NOA36 PF06524.12 ETO03455.1 - 0.38 10.0 13.8 0.46 9.8 13.8 1.1 1 0 0 1 1 1 0 NOA36 protein CLN3 PF02487.17 ETO03455.1 - 0.63 9.0 1.9 0.6 9.1 1.9 1.2 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 ETO03455.1 - 0.85 8.3 13.2 0.99 8.1 13.2 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO03455.1 - 0.89 8.5 11.4 0.99 8.4 11.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 ALMT PF11744.8 ETO03455.1 - 0.91 8.3 7.5 0.9 8.3 7.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Gti1_Pac2 PF09729.9 ETO03455.1 - 2.4 8.2 13.2 3.6 7.7 13.2 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family HCO3_cotransp PF00955.21 ETO03455.1 - 3.1 6.5 5.8 3.2 6.5 5.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family MRNIP PF15749.5 ETO03455.1 - 5.4 7.8 17.8 10 6.9 17.8 1.5 1 0 0 1 1 1 0 MRN-interacting protein Zip PF02535.22 ETO03455.1 - 6 6.0 9.0 7.4 5.7 9.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MNR PF15718.5 ETO03456.1 - 5.5 5.0 11.2 6.3 4.8 11.2 1.0 1 0 0 1 1 1 0 Protein moonraker NPR3 PF03666.13 ETO03456.1 - 5.8 5.6 9.7 5 5.8 9.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1754 PF08555.10 ETO03456.1 - 6.2 7.7 18.6 2.3 9.1 15.6 1.9 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Apis_Csd PF11671.8 ETO03456.1 - 7.6 6.5 20.1 0.25 11.3 14.1 1.7 1 1 1 2 2 2 0 Complementary sex determiner protein Presenilin PF01080.17 ETO03456.1 - 9.8 4.8 7.2 9.4 4.9 7.2 1.2 1 0 0 1 1 1 0 Presenilin DUF2415 PF10313.9 ETO03463.1 - 0.11 12.4 0.0 0.28 11.2 0.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein domain (DUF2415) HSP70 PF00012.20 ETO03464.1 - 0.00026 19.3 0.0 0.16 10.2 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein Peptidase_M22 PF00814.25 ETO03464.1 - 0.04 13.6 0.0 0.072 12.8 0.0 1.4 1 0 0 1 1 1 0 Glycoprotease family Serinc PF03348.15 ETO03466.1 - 0.23 10.4 2.6 0.26 10.2 2.6 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM176 PF14851.6 ETO03466.1 - 3.7 7.2 8.0 5.4 6.7 8.0 1.3 1 0 0 1 1 1 0 FAM176 family MAP17 PF15807.5 ETO03466.1 - 4.6 7.5 10.9 6.8 6.9 10.9 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Sec62 PF03839.16 ETO03466.1 - 4.8 6.6 9.9 7 6.1 9.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Striatin PF08232.12 ETO03466.1 - 8.7 6.9 13.7 12 6.4 13.7 1.3 1 1 0 1 1 1 0 Striatin family Nitr_red_assoc PF09655.10 ETO03468.1 - 1.9 9.1 10.1 0.13 12.9 3.4 2.0 2 0 0 2 2 2 0 Conserved nitrate reductase-associated protein (Nitr_red_assoc) Ank_3 PF13606.6 ETO03469.1 - 3.9e-08 32.9 1.5 0.00021 21.5 0.0 4.4 5 0 0 5 5 5 2 Ankyrin repeat Ank_2 PF12796.7 ETO03469.1 - 2e-06 28.3 0.1 1.2e-05 25.8 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO03469.1 - 7.9e-06 26.1 0.1 2.9e-05 24.3 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO03469.1 - 1.3e-05 25.7 0.4 0.00013 22.5 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO03469.1 - 0.0012 19.2 0.0 0.0071 16.8 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeat Sacchrp_dh_NADP PF03435.18 ETO03469.1 - 0.059 13.6 0.1 0.12 12.7 0.1 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Cnd1 PF12717.7 ETO03470.1 - 4e-10 40.0 1.6 1.8e-05 24.8 1.0 3.0 1 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO03470.1 - 3.2e-09 36.3 0.1 0.005 17.0 0.0 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ETO03470.1 - 1.7e-08 34.7 0.0 0.00089 19.6 0.0 3.1 1 1 2 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ETO03470.1 - 1.4e-06 28.6 0.0 0.15 12.6 0.0 3.3 2 1 1 3 3 3 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO03470.1 - 1.8e-05 25.3 1.4 0.0043 17.6 0.1 2.9 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO03470.1 - 4.2e-05 23.2 0.3 0.00083 19.0 0.2 2.1 1 1 0 2 2 2 1 CLASP N terminal TIP120 PF08623.10 ETO03470.1 - 0.0003 20.6 3.2 0.037 13.8 0.1 3.4 1 1 3 4 4 4 2 TATA-binding protein interacting (TIP20) DNA_alkylation PF08713.11 ETO03470.1 - 0.00032 20.5 0.0 0.00041 20.1 0.0 1.2 1 0 0 1 1 1 1 DNA alkylation repair enzyme RTP1_C1 PF10363.9 ETO03470.1 - 0.0016 18.6 0.1 0.025 14.8 0.0 2.5 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 IFRD PF05004.13 ETO03470.1 - 0.0032 16.6 0.7 0.032 13.3 0.4 2.5 1 1 1 3 3 3 1 Interferon-related developmental regulator (IFRD) HEAT_PBS PF03130.16 ETO03470.1 - 0.016 15.9 0.0 7.9 7.5 0.0 3.4 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF5105 PF17118.5 ETO03470.1 - 0.019 14.7 0.1 3.1 7.5 0.0 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF5105) BRCA-2_OB3 PF09104.10 ETO03470.1 - 0.02 14.5 0.3 0.5 10.0 0.1 2.3 2 0 0 2 2 2 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 CCDC-167 PF15188.6 ETO03470.1 - 0.07 13.5 2.4 2 8.8 1.6 2.8 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 MOLO1 PF17175.4 ETO03470.1 - 0.09 12.9 1.9 0.78 9.9 0.7 2.3 1 1 0 2 2 2 0 Modulator of levamisole receptor-1 NLRC4_HD2 PF17776.1 ETO03470.1 - 0.098 13.2 3.4 0.72 10.4 0.2 2.2 1 1 1 2 2 2 0 NLRC4 helical domain HD2 Sen15 PF09631.10 ETO03470.1 - 0.14 12.4 0.1 1 9.7 0.0 2.3 1 1 1 2 2 2 0 Sen15 protein NblA PF04485.12 ETO03471.1 - 0.011 16.1 0.1 0.021 15.2 0.1 1.5 1 0 0 1 1 1 0 Phycobilisome degradation protein nblA Tubulin_C PF03953.17 ETO03471.1 - 0.014 15.6 0.6 0.016 15.4 0.6 1.1 1 0 0 1 1 1 0 Tubulin C-terminal domain FliG_C PF01706.16 ETO03471.1 - 0.056 13.6 0.1 0.066 13.4 0.1 1.1 1 0 0 1 1 1 0 FliG C-terminal domain UCH PF00443.29 ETO03472.1 - 1.6e-16 60.6 1.0 2.1e-16 60.2 1.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO03472.1 - 0.0011 18.7 8.7 0.0023 17.6 8.7 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1181 PF06680.11 ETO03472.1 - 0.083 12.7 0.1 0.14 12.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1181) Pkinase PF00069.25 ETO03473.1 - 6e-27 94.7 0.1 1.2e-26 93.6 0.1 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03473.1 - 1.1e-05 24.8 0.0 6e-05 22.5 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase RRM_1 PF00076.22 ETO03474.1 - 3.2e-64 212.7 4.4 4.9e-18 64.7 0.0 4.8 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO03474.1 - 1e-10 41.3 0.0 0.15 12.0 0.0 4.6 4 0 0 4 4 4 3 Occluded RNA-recognition motif RRM_7 PF16367.5 ETO03474.1 - 1.6e-10 40.9 0.5 0.076 13.1 0.0 4.9 4 0 0 4 4 4 3 RNA recognition motif Nup35_RRM_2 PF14605.6 ETO03474.1 - 2.9e-08 33.6 0.7 0.026 14.5 0.1 4.5 5 0 0 5 5 4 2 Nup53/35/40-type RNA recognition motif RL PF17797.1 ETO03474.1 - 6.8e-05 22.7 0.2 0.021 14.8 0.2 3.6 3 0 0 3 3 3 1 RL domain SET_assoc PF11767.8 ETO03474.1 - 0.028 14.1 1.7 1.2 8.8 0.0 3.5 4 0 0 4 4 4 0 Histone lysine methyltransferase SET associated UPF0020 PF01170.18 ETO03474.1 - 0.057 13.1 2.7 2.8 7.6 0.2 3.2 3 1 1 4 4 4 0 Putative RNA methylase family UPF0020 RRM_3 PF08777.11 ETO03474.1 - 0.081 13.0 0.0 0.081 13.0 0.0 5.3 5 1 1 6 6 6 0 RNA binding motif Rgp1 PF08737.10 ETO03474.1 - 0.29 10.3 27.5 0.9 8.6 8.3 2.3 2 0 0 2 2 2 0 Rgp1 Presenilin PF01080.17 ETO03474.1 - 4.9 5.8 28.5 4.4 6.0 8.6 2.2 2 0 0 2 2 2 0 Presenilin CCSAP PF15748.5 ETO03474.1 - 9.8 6.3 29.3 11 6.1 9.1 2.6 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated HTH_43 PF09904.9 ETO03477.1 - 0.24 11.4 1.8 0.96 9.4 0.5 2.6 2 1 1 3 3 3 0 Winged helix-turn helix CAAP1 PF15335.6 ETO03480.1 - 0.48 11.0 4.3 12 6.6 0.1 2.8 2 0 0 2 2 2 0 Caspase activity and apoptosis inhibitor 1 DUF4093 PF13331.6 ETO03481.1 - 0.018 15.5 0.1 0.071 13.5 0.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) DUF2063 PF09836.9 ETO03481.1 - 0.031 14.5 0.0 1.1 9.6 0.0 3.2 3 0 0 3 3 3 0 Putative DNA-binding domain ACP_PD PF04336.12 ETO03481.1 - 0.068 13.6 1.0 4.1 7.9 0.1 3.3 3 0 0 3 3 3 0 Acyl carrier protein phosphodiesterase Tsi6 PF18660.1 ETO03481.1 - 3.7 7.7 7.4 8.3 6.5 0.1 3.9 4 0 0 4 4 4 0 Tsi6 Peptidase_M20 PF01546.28 ETO03482.1 - 2.1e-07 30.9 0.0 2.7e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 RNase_H PF00075.24 ETO03483.1 - 1.1e-09 38.7 0.0 5.9e-05 23.3 0.0 2.1 1 1 1 2 2 2 2 RNase H zf-RVT PF13966.6 ETO03484.1 - 0.015 16.0 0.3 0.025 15.3 0.3 1.4 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase RVT_1 PF00078.27 ETO03486.1 - 3.9e-11 42.9 0.2 7.4e-11 42.0 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 ETO03486.1 - 3.8e-06 26.9 0.0 1.3e-05 25.2 0.0 1.8 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase Ras PF00071.22 ETO03488.1 - 5.8e-08 32.5 0.1 3e-07 30.2 0.1 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO03488.1 - 0.044 14.0 0.0 0.1 12.8 0.0 1.9 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Connexin PF00029.19 ETO03489.1 - 0.89 9.3 5.2 0.99 9.1 5.2 1.2 1 0 0 1 1 1 0 Connexin O-antigen_lig PF13425.6 ETO03489.1 - 5.4 5.7 10.8 6.4 5.4 10.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF5400 PF17379.2 ETO03490.1 - 0.075 13.5 0.1 0.15 12.6 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5400) TMEM208_SND2 PF05620.11 ETO03492.1 - 0.036 13.8 1.2 0.065 13.0 1.2 1.4 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 MadL PF03817.13 ETO03492.1 - 0.12 12.4 0.1 0.19 11.8 0.1 1.3 1 0 0 1 1 1 0 Malonate transporter MadL subunit ParcG PF10274.9 ETO03493.1 - 0.025 14.7 0.1 0.069 13.3 0.0 1.7 2 0 0 2 2 2 0 Parkin co-regulated protein WD40 PF00400.32 ETO03494.1 - 3.8e-42 141.5 17.9 2.8e-06 27.9 0.0 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03494.1 - 3.5e-14 52.9 0.4 0.055 13.8 0.0 6.3 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03494.1 - 1.8e-12 46.7 2.5 0.037 12.7 0.0 5.4 1 1 4 6 6 6 4 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO03494.1 - 0.0003 20.6 0.0 4.3 7.2 0.0 3.9 3 0 0 3 3 3 2 ATP-dependent RecD-like DNA helicase SH3 domain WD40_like PF17005.5 ETO03494.1 - 0.009 15.4 11.2 0.025 13.9 0.0 4.6 4 1 1 5 5 5 1 WD40-like domain SAB PF04382.13 ETO03494.1 - 0.044 13.9 2.3 0.096 12.8 2.3 1.6 1 0 0 1 1 1 0 SAB domain GBP_C PF02841.14 ETO03494.1 - 1.3 8.4 14.7 1.7 8.0 14.7 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain zf-TRAF PF02176.18 ETO03495.1 - 4.6e-07 30.4 4.5 4.6e-07 30.4 4.5 2.0 2 1 0 2 2 2 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO03495.1 - 0.0066 16.9 6.7 0.042 14.3 1.4 2.2 1 1 1 2 2 2 2 TRAF-like zinc-finger Sina PF03145.16 ETO03495.1 - 0.065 13.2 6.4 0.75 9.7 3.8 2.8 1 1 1 3 3 3 0 Seven in absentia protein family WD40 PF00400.32 ETO03496.1 - 3e-12 46.9 10.4 1.3e-05 25.8 0.8 3.8 3 2 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO03496.1 - 0.00028 20.3 1.3 0.1 11.9 0.4 2.2 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO03496.1 - 0.012 14.3 0.1 0.098 11.3 0.1 1.9 1 1 0 1 1 1 0 Nucleoporin Nup120/160 Borrelia_P83 PF05262.11 ETO03496.1 - 0.11 11.0 0.0 0.13 10.7 0.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF2353 PF09789.9 ETO03498.1 - 0.0001 21.8 2.1 0.0001 21.8 2.1 1.9 2 0 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) JAKMIP_CC3 PF16034.5 ETO03498.1 - 0.00018 21.5 2.2 0.00018 21.5 2.2 2.2 2 0 0 2 2 2 1 JAKMIP CC3 domain TMF_TATA_bd PF12325.8 ETO03498.1 - 0.0049 17.1 10.5 0.012 15.9 1.6 3.0 3 0 0 3 3 3 1 TATA element modulatory factor 1 TATA binding Inv-AAD PF18785.1 ETO03498.1 - 0.01 15.7 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase CENP-K PF11802.8 ETO03498.1 - 0.014 15.0 7.4 0.02 14.5 7.4 1.3 1 0 0 1 1 1 0 Centromere-associated protein K PRKG1_interact PF15898.5 ETO03498.1 - 0.055 14.4 3.9 0.055 14.4 3.9 3.1 3 1 0 3 3 2 0 cGMP-dependent protein kinase interacting domain BLOC1_2 PF10046.9 ETO03498.1 - 0.057 13.7 5.0 0.3 11.4 0.4 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spectrin PF00435.21 ETO03498.1 - 0.072 13.6 6.7 0.21 12.1 1.8 2.5 2 0 0 2 2 2 0 Spectrin repeat DivIC PF04977.15 ETO03498.1 - 0.11 12.3 13.0 1.6 8.6 3.1 3.6 3 1 1 4 4 4 0 Septum formation initiator DUF3450 PF11932.8 ETO03498.1 - 0.42 9.9 4.4 0.098 11.9 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SOGA PF11365.8 ETO03498.1 - 0.45 11.7 7.0 0.099 13.8 2.4 2.0 1 1 0 2 2 2 0 Protein SOGA HALZ PF02183.18 ETO03498.1 - 0.71 10.2 0.1 0.71 10.2 0.1 2.9 2 1 0 3 3 2 0 Homeobox associated leucine zipper DUF4140 PF13600.6 ETO03498.1 - 0.82 10.1 5.0 19 5.8 0.1 2.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF16 PF01519.16 ETO03498.1 - 1.2 9.7 12.4 4.6 7.8 5.5 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 bZIP_1 PF00170.21 ETO03498.1 - 1.2 9.3 15.8 0.57 10.3 2.9 3.6 2 2 1 3 3 3 0 bZIP transcription factor DUF4446 PF14584.6 ETO03498.1 - 1.2 9.1 12.1 1.1 9.3 1.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) Laminin_II PF06009.12 ETO03498.1 - 2.8 8.0 9.1 0.67 10.0 3.3 2.3 1 1 1 2 2 2 0 Laminin Domain II TolA_bind_tri PF16331.5 ETO03498.1 - 3.8 7.6 8.8 6.1 7.0 0.2 3.0 2 1 1 3 3 3 0 TolA binding protein trimerisation KELK PF15796.5 ETO03498.1 - 4.8 7.7 12.4 28 5.2 3.4 3.1 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase CENP-H PF05837.12 ETO03498.1 - 5.2 7.5 13.6 7.6 7.0 0.3 3.1 2 1 0 3 3 2 0 Centromere protein H (CENP-H) SlyX PF04102.12 ETO03498.1 - 7 7.3 6.5 26 5.5 0.1 3.2 2 1 0 2 2 2 0 SlyX Cep57_CLD_2 PF14197.6 ETO03498.1 - 9.4 6.4 11.0 12 6.1 0.4 2.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 RNA_polI_A14 PF08203.11 ETO03498.1 - 10 7.0 8.1 4.5 8.1 0.5 2.5 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 TLD PF07534.16 ETO03499.1 - 6.1e-10 39.5 0.0 1.8e-09 37.9 0.0 1.9 1 0 0 1 1 1 1 TLD Gp-FAR-1 PF05823.12 ETO03499.1 - 0.081 13.3 5.5 0.089 13.2 4.2 1.7 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) EST1 PF10374.9 ETO03499.1 - 0.31 11.7 2.3 0.55 10.9 2.3 1.4 1 0 0 1 1 1 0 Telomerase activating protein Est1 COG5 PF10392.9 ETO03499.1 - 4.1 7.6 9.5 9.6 6.4 5.5 2.6 2 1 1 3 3 3 0 Golgi transport complex subunit 5 Presenilin PF01080.17 ETO03500.1 - 0.0013 17.6 8.7 0.0013 17.6 8.7 2.5 2 0 0 2 2 2 1 Presenilin DUF948 PF06103.11 ETO03500.1 - 0.74 10.1 5.9 1.1 9.5 1.3 2.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Chal_sti_synt_C PF02797.15 ETO03500.1 - 1.8 8.5 5.0 5.6 6.9 0.1 3.0 2 1 1 3 3 3 0 Chalcone and stilbene synthases, C-terminal domain TPR_12 PF13424.6 ETO03501.1 - 3.6e-58 193.8 15.3 3.3e-20 72.1 1.1 3.3 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03501.1 - 2.6e-36 122.5 0.6 1.4e-09 37.5 0.0 4.0 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03501.1 - 2.8e-28 96.5 22.4 2.4e-09 36.6 0.9 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03501.1 - 1.2e-23 81.3 19.9 5.3e-07 29.3 0.4 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03501.1 - 3.3e-23 79.9 17.2 4.8e-07 29.4 0.5 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03501.1 - 1.1e-22 78.3 2.7 8.3e-06 25.5 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03501.1 - 3.5e-12 45.8 23.9 1.8e-06 27.5 0.5 5.8 4 2 2 6 6 6 3 TPR repeat TPR_14 PF13428.6 ETO03501.1 - 1.2e-10 41.3 0.0 0.57 11.1 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03501.1 - 1.3e-10 41.7 0.1 0.0002 21.9 0.0 3.3 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03501.1 - 1.6e-10 40.9 2.9 0.015 15.9 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO03501.1 - 2.8e-10 39.5 0.7 0.0035 16.7 0.0 4.1 4 0 0 4 4 4 3 SHNi-TPR TPR_17 PF13431.6 ETO03501.1 - 8.1e-10 38.4 10.2 0.0065 16.8 0.0 4.4 3 2 0 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.6 ETO03501.1 - 1.6e-06 27.8 2.1 5.1e-06 26.1 2.2 1.7 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 ETO03501.1 - 1.5e-05 25.1 8.2 0.0019 18.4 1.7 2.5 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 HTH_Bact PF18768.1 ETO03501.1 - 1.6e-05 24.4 6.7 2.3 7.9 0.1 4.3 4 0 0 4 4 4 1 Helix-turn-helix bacterial domain DUF5113 PF17140.4 ETO03501.1 - 0.00022 21.1 7.3 0.62 9.8 0.2 3.6 4 0 0 4 4 4 2 Domain of unknown function (DUF5113) DUF627 PF04781.12 ETO03501.1 - 0.0003 20.8 1.8 0.37 10.8 0.1 3.2 2 1 0 3 3 3 1 Protein of unknown function (DUF627) SPO22 PF08631.10 ETO03501.1 - 0.00089 18.8 2.5 0.087 12.3 0.5 2.3 2 1 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like DUF2225 PF09986.9 ETO03501.1 - 0.0011 18.7 5.4 0.0095 15.7 0.5 2.2 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO03501.1 - 0.0015 18.6 9.8 0.44 10.6 0.1 3.9 3 1 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO03501.1 - 0.0015 19.0 0.5 0.03 14.8 0.2 2.6 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO03501.1 - 0.0023 17.9 1.0 0.0023 17.9 1.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO03501.1 - 0.0025 18.5 7.5 3.6 8.4 0.1 4.0 4 1 0 4 4 4 1 Sel1 repeat TPR_MalT PF17874.1 ETO03501.1 - 0.0084 15.5 0.0 0.0084 15.5 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region NSF PF02071.20 ETO03501.1 - 0.015 15.9 1.6 38 5.7 0.1 3.8 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat ATP-synt_E_2 PF08112.11 ETO03501.1 - 0.015 15.6 4.1 7.5 6.9 0.1 3.8 4 0 0 4 4 4 0 ATP synthase epsilon subunit Vta1_C PF18097.1 ETO03501.1 - 0.019 14.7 0.9 1.9 8.2 0.1 2.8 3 0 0 3 3 3 0 Vta1 C-terminal domain YflT PF11181.8 ETO03501.1 - 0.021 15.3 1.0 0.79 10.3 0.1 2.2 2 0 0 2 2 2 0 Heat induced stress protein YflT DUF3856 PF12968.7 ETO03501.1 - 0.056 13.5 0.8 0.59 10.2 0.2 2.4 1 1 2 3 3 3 0 Domain of Unknown Function (DUF3856) DUF1938 PF09153.10 ETO03501.1 - 0.09 12.9 0.9 10 6.3 0.0 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF1938) TPR_15 PF13429.6 ETO03501.1 - 0.098 11.8 0.7 0.18 11.0 0.3 1.8 2 1 0 2 2 2 0 Tetratricopeptide repeat OEP PF02321.18 ETO03501.1 - 0.34 10.7 5.7 5.3 6.8 1.7 2.6 1 1 2 3 3 3 0 Outer membrane efflux protein Mistic PF11458.8 ETO03501.1 - 0.43 10.6 6.4 15 5.7 0.0 3.5 3 1 1 4 4 4 0 Membrane-integrating protein Mistic Sda PF08970.10 ETO03501.1 - 0.71 9.6 3.6 24 4.8 0.1 3.0 3 0 0 3 3 3 0 Sporulation inhibitor A PPR PF01535.20 ETO03501.1 - 0.86 10.0 3.9 28 5.2 0.0 4.3 5 1 0 5 5 4 0 PPR repeat UVR PF02151.19 ETO03501.1 - 2.3 8.1 10.0 2.4 8.0 0.1 3.9 4 1 1 5 5 5 0 UvrB/uvrC motif Calci_bind_CcbP PF11535.8 ETO03503.1 - 2.6 8.6 5.6 1.1 9.8 0.1 2.4 2 1 1 3 3 3 0 Calcium binding Allexi_40kDa PF05549.11 ETO03503.1 - 7.8 5.9 6.5 26 4.2 0.0 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein UPF0515 PF15135.6 ETO03504.1 - 0.17 11.2 2.4 0.37 10.1 2.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 CPW_WPC PF09717.10 ETO03505.1 - 0.026 15.5 0.3 0.059 14.4 0.2 1.6 1 1 0 1 1 1 0 Plasmodium falciparum domain of unknown function (CPW_WPC) Vfa1 PF08432.10 ETO03506.1 - 0.013 15.9 13.0 0.013 15.9 13.0 1.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 ETO03506.1 - 0.047 12.4 4.9 0.043 12.6 4.9 1.2 1 0 0 1 1 1 0 Presenilin Atrophin-1 PF03154.15 ETO03506.1 - 0.049 11.9 11.0 0.056 11.7 11.0 1.0 1 0 0 1 1 1 0 Atrophin-1 family Zip PF02535.22 ETO03506.1 - 0.069 12.4 2.5 0.071 12.3 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Amino_oxidase PF01593.24 ETO03506.1 - 0.071 12.4 0.3 0.083 12.2 0.3 1.1 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase NPR3 PF03666.13 ETO03506.1 - 0.1 11.4 11.2 0.11 11.3 11.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4228 PF14009.6 ETO03506.1 - 0.14 12.5 4.4 0.14 12.5 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Connexin PF00029.19 ETO03506.1 - 0.81 9.4 10.6 1.4 8.7 10.6 1.4 1 0 0 1 1 1 0 Connexin Otopetrin PF03189.13 ETO03506.1 - 1.2 7.9 3.4 1.2 7.9 3.4 1.1 1 0 0 1 1 1 0 Otopetrin ALMT PF11744.8 ETO03506.1 - 2.8 6.7 9.5 4.1 6.1 9.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1754 PF08555.10 ETO03506.1 - 3.1 8.6 31.3 0.45 11.3 26.2 2.0 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) FAM176 PF14851.6 ETO03506.1 - 3.9 7.1 11.1 1.3 8.7 8.4 1.6 2 0 0 2 2 2 0 FAM176 family MDM10 PF12519.8 ETO03506.1 - 3.9 6.2 10.9 4.2 6.1 10.9 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CobT PF06213.12 ETO03506.1 - 4.4 6.6 10.2 6 6.2 10.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 ETO03506.1 - 4.6 7.4 12.7 8.1 6.6 12.7 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1764 PF08576.10 ETO03506.1 - 5.2 8.0 20.5 1.1 10.2 16.5 1.8 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) CLN3 PF02487.17 ETO03506.1 - 7.6 5.5 6.4 10 5.1 6.4 1.2 1 0 0 1 1 1 0 CLN3 protein NARP1 PF12569.8 ETO03507.1 - 0.6 9.0 31.2 0.78 8.6 31.2 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF2052 PF09747.9 ETO03507.1 - 7.1 6.7 27.2 11 6.1 27.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO03507.1 - 8.7 4.5 28.5 10 4.3 28.5 1.0 1 0 0 1 1 1 0 CDC45-like protein GW PF13457.6 ETO03508.1 - 0.048 14.3 0.1 0.1 13.2 0.1 1.6 1 0 0 1 1 1 0 GW (Gly-Tryp) dipeptide domain DX PF01666.17 ETO03508.1 - 2 8.9 7.8 18 5.9 3.1 2.7 2 2 0 2 2 2 0 DX module HNF_C PF09354.10 ETO03509.1 - 0.12 13.4 0.2 0.12 13.4 0.2 1.7 2 0 0 2 2 2 0 HNF3 C-terminal domain DUF2884 PF11101.8 ETO03514.1 - 0.22 11.0 0.1 0.31 10.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) Tubulin PF00091.25 ETO03515.1 - 2.6e-30 106.1 0.2 3.9e-30 105.5 0.2 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO03515.1 - 0.00043 20.5 0.1 0.00089 19.4 0.1 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO03515.1 - 0.16 11.1 0.2 0.25 10.5 0.2 1.3 1 1 0 1 1 1 0 Tubulin like Glyoxalase_2 PF12681.7 ETO03516.1 - 0.05 13.5 1.8 0.52 10.3 0.3 2.5 2 0 0 2 2 2 0 Glyoxalase-like domain AbiEi_3 PF11459.8 ETO03516.1 - 0.075 12.7 0.1 0.18 11.5 0.1 1.5 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system Pox_VLTF3 PF04947.14 ETO03516.1 - 0.13 11.9 10.6 0.17 11.6 0.5 2.9 3 1 0 3 3 3 0 Poxvirus Late Transcription Factor VLTF3 like Kelch_2 PF07646.15 ETO03517.1 - 0.0012 18.7 0.4 0.0026 17.7 0.4 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 ETO03517.1 - 0.011 15.4 0.2 0.019 14.5 0.2 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 ETO03517.1 - 0.049 13.9 0.0 0.075 13.4 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.6 ETO03517.1 - 0.063 13.3 0.6 0.13 12.3 0.1 1.8 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO03517.1 - 0.12 12.4 0.2 0.19 11.7 0.2 1.5 1 0 0 1 1 1 0 Kelch motif ERAP1_C PF11838.8 ETO03520.1 - 1.7e-10 41.0 0.0 2e-10 40.7 0.0 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain DnaB_2 PF07261.11 ETO03520.1 - 0.084 12.6 1.8 6.1 6.7 0.1 2.4 2 0 0 2 2 2 0 Replication initiation and membrane attachment HEAT PF02985.22 ETO03522.1 - 5.6e-14 51.1 0.1 0.0024 18.0 0.0 3.6 3 0 0 3 3 3 3 HEAT repeat HEAT_2 PF13646.6 ETO03522.1 - 4.3e-13 49.5 0.0 6.6e-08 32.8 0.1 2.2 1 1 1 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 ETO03522.1 - 2e-07 31.4 0.0 0.0065 17.0 0.0 2.3 1 1 1 2 2 2 2 HEAT-like repeat Cnd1 PF12717.7 ETO03522.1 - 2.9e-06 27.4 0.6 3.7e-06 27.1 0.6 1.2 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_PBS PF03130.16 ETO03522.1 - 1.4e-05 25.3 0.0 0.13 13.0 0.0 3.8 4 0 0 4 4 4 1 PBS lyase HEAT-like repeat CLASP_N PF12348.8 ETO03522.1 - 0.00065 19.3 0.4 0.076 12.6 0.1 2.2 1 1 1 2 2 2 2 CLASP N terminal TIP120 PF08623.10 ETO03522.1 - 0.0028 17.4 0.6 0.4 10.4 0.2 2.4 1 1 1 2 2 2 2 TATA-binding protein interacting (TIP20) Gcn1_N PF12074.8 ETO03522.1 - 0.0065 15.8 0.6 0.62 9.3 0.1 2.1 1 1 1 2 2 2 2 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Vac14_Fab1_bd PF12755.7 ETO03522.1 - 0.008 16.7 0.2 0.62 10.7 0.0 2.5 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region FPL PF09758.9 ETO03522.1 - 0.18 11.8 3.5 7.2 6.6 0.3 2.4 1 1 1 2 2 2 0 Uncharacterised conserved protein DUF4172 PF13776.6 ETO03522.1 - 0.42 11.0 2.3 10 6.5 0.0 3.3 2 1 0 3 3 3 0 Domain of unknown function (DUF4172) PsbW PF07123.12 ETO03523.1 - 0.095 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Photosystem II reaction centre W protein (PsbW) PPL5 PF18168.1 ETO03523.1 - 0.7 9.1 5.0 0.84 8.9 5.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF3987 PF13148.6 ETO03523.1 - 7.5 5.5 6.1 9.2 5.2 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Peptidase_M16_M PF16187.5 ETO03524.1 - 9.6e-45 153.0 2.7 4.7e-44 150.8 2.7 1.9 1 1 0 1 1 1 1 Middle or third domain of peptidase_M16 DPPIV_rep PF18811.1 ETO03525.1 - 0.36 10.8 0.2 0.36 10.8 0.2 1.9 2 0 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) low complexity region TPR_12 PF13424.6 ETO03527.1 - 2.5e-39 133.4 8.1 1.6e-21 76.4 1.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03527.1 - 2.1e-32 109.6 31.7 3.7e-11 42.3 2.8 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03527.1 - 6.4e-27 92.6 5.9 1.1e-09 37.8 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03527.1 - 1.1e-24 84.4 21.7 1.2e-08 34.4 2.6 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03527.1 - 5.6e-22 76.1 26.7 7.6e-08 32.0 1.4 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03527.1 - 1.5e-21 74.7 8.0 1.1e-05 25.1 0.0 4.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03527.1 - 3.6e-18 65.9 0.0 3.4e-07 30.8 0.0 3.2 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03527.1 - 6.1e-16 57.9 3.0 0.0035 17.9 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03527.1 - 4.3e-14 51.9 39.0 3.9e-05 23.2 1.1 6.8 4 3 3 7 7 7 5 TPR repeat TPR_14 PF13428.6 ETO03527.1 - 1.5e-11 44.1 0.0 0.042 14.7 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03527.1 - 1.5e-09 37.6 25.0 0.0026 18.0 2.5 4.6 3 3 2 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03527.1 - 1.8e-07 31.3 11.2 0.00073 19.7 3.1 2.3 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ETO03527.1 - 3.5e-07 29.9 12.9 2.1e-05 24.1 5.2 2.2 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO03527.1 - 5.1e-07 29.7 16.7 0.042 13.9 0.4 4.1 4 0 0 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO03527.1 - 1.3e-06 28.9 6.1 0.016 15.7 1.1 3.2 2 2 0 2 2 2 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO03527.1 - 1.7e-06 27.9 16.5 0.046 13.5 0.8 3.6 4 0 0 4 4 4 3 Domain of unknown function (DUF5113) SPO22 PF08631.10 ETO03527.1 - 7.7e-06 25.6 3.8 0.0094 15.5 0.1 2.9 2 1 1 3 3 3 3 Meiosis protein SPO22/ZIP4 like SHNi-TPR PF10516.9 ETO03527.1 - 1.1e-05 24.8 5.7 0.55 9.7 0.1 3.9 4 0 0 4 4 4 2 SHNi-TPR DUF2225 PF09986.9 ETO03527.1 - 2.5e-05 24.1 6.9 0.0031 17.2 1.3 2.1 1 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) RPN7 PF10602.9 ETO03527.1 - 0.00049 19.9 5.9 0.0034 17.1 5.6 2.1 1 1 0 1 1 1 1 26S proteasome subunit RPN7 TPR_5 PF12688.7 ETO03527.1 - 0.00062 20.0 0.2 0.11 12.8 0.0 3.2 1 1 3 4 4 4 1 Tetratrico peptide repeat PPR PF01535.20 ETO03527.1 - 0.0011 19.0 2.0 0.7 10.3 0.3 3.4 3 0 0 3 3 3 1 PPR repeat TPR_3 PF07720.12 ETO03527.1 - 0.0014 18.6 19.5 0.0088 16.0 1.4 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO03527.1 - 0.0019 18.8 17.1 1.2 10.0 1.0 5.2 4 3 0 4 4 4 2 Sel1 repeat TPR_MalT PF17874.1 ETO03527.1 - 0.0077 15.6 0.0 0.011 15.1 0.0 1.4 1 1 0 1 1 1 1 MalT-like TPR region DUF627 PF04781.12 ETO03527.1 - 0.009 16.0 2.7 0.6 10.1 0.2 2.9 2 1 1 3 3 3 1 Protein of unknown function (DUF627) HTH_Bact PF18768.1 ETO03527.1 - 0.014 15.0 5.8 3.7 7.2 0.1 3.9 4 0 0 4 4 4 0 Helix-turn-helix bacterial domain Mob_Pre PF01076.19 ETO03527.1 - 0.038 13.8 0.6 0.038 13.8 0.6 2.1 1 1 1 2 2 2 0 Plasmid recombination enzyme Vta1_C PF18097.1 ETO03527.1 - 0.05 13.3 0.4 54 3.6 0.0 3.3 3 0 0 3 3 3 0 Vta1 C-terminal domain Goodbye PF17109.5 ETO03527.1 - 0.056 13.9 0.0 0.41 11.1 0.0 2.0 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain YflT PF11181.8 ETO03527.1 - 0.06 13.9 0.6 0.77 10.3 0.3 2.2 1 1 1 2 2 2 0 Heat induced stress protein YflT NSF PF02071.20 ETO03527.1 - 0.076 13.8 13.4 13 7.1 0.1 5.3 5 0 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat Sda PF08970.10 ETO03527.1 - 0.16 11.7 7.5 2.9 7.7 0.1 3.7 4 0 0 4 4 3 0 Sporulation inhibitor A Prefoldin PF02996.17 ETO03527.1 - 0.24 11.3 3.8 2 8.3 0.5 3.0 2 1 1 3 3 3 0 Prefoldin subunit EMP70 PF02990.16 ETO03528.1 - 2.2e-72 244.4 16.8 5.5e-47 160.6 9.3 2.0 1 1 1 2 2 2 2 Endomembrane protein 70 THB PF18362.1 ETO03528.1 - 0.019 14.6 1.5 0.044 13.4 0.2 2.1 1 1 1 2 2 2 0 Tri-helix bundle domain EcsB PF05975.12 ETO03528.1 - 0.39 9.5 13.3 0.093 11.6 9.5 1.8 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB CPP1-like PF11833.8 ETO03528.1 - 2.9 7.5 5.2 1.9 8.1 2.5 2.0 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF2663 PF10864.8 ETO03528.1 - 2.9 8.3 14.0 2.3 8.7 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2663) Sec6 PF06046.13 ETO03529.1 - 5.3e-40 137.4 21.0 6.8e-40 137.0 21.0 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec6 TaqI_C PF12950.7 ETO03529.1 - 0.02 15.0 0.7 0.17 11.9 0.5 2.5 2 0 0 2 2 2 0 TaqI-like C-terminal specificity domain MIEAP PF16026.5 ETO03530.1 - 0.015 15.5 6.0 0.02 15.1 5.8 1.4 1 1 0 1 1 1 0 Mitochondria-eating protein Pox_polyA_pol_C PF12629.7 ETO03530.1 - 0.08 12.8 3.6 0.13 12.1 3.4 1.3 1 1 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain Peptidase_M3 PF01432.20 ETO03531.1 - 2.1e-21 76.8 0.6 3.6e-21 76.0 0.6 1.4 1 1 0 1 1 1 1 Peptidase family M3 zf-RVT PF13966.6 ETO03532.1 - 0.023 15.4 0.0 0.053 14.2 0.0 1.6 1 0 0 1 1 1 0 zinc-binding in reverse transcriptase WD40 PF00400.32 ETO03533.1 - 1.5e-09 38.3 4.8 3e-05 24.7 0.4 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03533.1 - 0.00013 22.2 0.0 0.14 12.5 0.0 2.4 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03533.1 - 0.0017 17.1 0.3 0.13 10.9 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Pico_P2A PF00947.19 ETO03533.1 - 0.051 13.6 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Picornavirus core protein 2A HEAT_2 PF13646.6 ETO03536.1 - 9.1e-23 80.5 0.0 3.2e-08 33.8 0.0 6.2 2 1 2 5 5 5 3 HEAT repeats HEAT PF02985.22 ETO03536.1 - 6e-22 75.9 0.1 0.0029 17.7 0.0 8.8 11 0 0 11 11 9 5 HEAT repeat HEAT_EZ PF13513.6 ETO03536.1 - 7.1e-16 58.3 0.0 0.015 15.7 0.0 6.5 4 2 2 6 6 6 3 HEAT-like repeat Cnd1 PF12717.7 ETO03536.1 - 1.6e-12 47.8 26.8 8.7e-06 25.9 0.9 6.3 1 1 5 6 6 6 4 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO03536.1 - 1.3e-08 35.3 5.6 0.066 13.8 0.1 5.7 2 2 6 8 8 8 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO03536.1 - 7.7e-08 32.2 6.7 0.002 17.8 0.5 4.2 2 1 1 3 3 3 2 CLASP N terminal RTP1_C1 PF10363.9 ETO03536.1 - 8.6e-08 32.4 3.5 0.38 10.9 0.0 5.9 2 2 3 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 Arm-DNA-bind_2 PF12167.8 ETO03536.1 - 1e-06 28.5 0.3 4.9 7.2 0.0 6.4 7 0 0 7 7 6 1 Arm DNA-binding domain RsfS PF02410.15 ETO03536.1 - 2.9e-06 27.6 2.4 2 8.9 0.3 5.1 1 1 1 2 2 2 2 Ribosomal silencing factor during starvation GhoS PF11080.8 ETO03536.1 - 1e-05 25.4 0.8 0.24 11.4 0.0 4.3 3 1 1 4 4 4 1 Endoribonuclease GhoS NLE PF08154.12 ETO03536.1 - 2.1e-05 25.0 6.9 7.5 7.2 0.0 6.4 6 1 1 7 7 6 0 NLE (NUC135) domain HEAT_PBS PF03130.16 ETO03536.1 - 0.00012 22.4 0.0 79 4.4 0.0 5.8 6 0 0 6 6 5 0 PBS lyase HEAT-like repeat Tsi6 PF18660.1 ETO03536.1 - 0.00068 19.6 1.1 8.4 6.5 0.0 4.7 3 2 1 4 4 4 0 Tsi6 Ribosomal_S3Ae PF01015.18 ETO03536.1 - 0.0035 17.0 8.7 0.16 11.5 0.0 4.9 2 1 4 6 6 6 1 Ribosomal S3Ae family DUF5063 PF16702.5 ETO03536.1 - 0.01 16.3 1.1 12 6.3 0.1 4.7 1 1 2 3 3 3 0 Domain of unknown function (DUF5063) DUF5071 PF16804.5 ETO03536.1 - 0.018 15.3 4.4 1.1 9.5 0.0 4.6 2 2 2 5 5 5 0 Domain of unknown function (DUF5071) T3RM_EcoP15I_C PF18273.1 ETO03536.1 - 0.023 15.0 10.1 63 4.0 0.0 6.8 4 2 4 8 8 7 0 Type III R-M EcoP15I C-terminal domain DUF2612 PF11041.8 ETO03536.1 - 0.024 14.6 0.6 0.056 13.4 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2612) EABR PF12180.8 ETO03536.1 - 0.06 13.0 0.5 65 3.3 0.0 4.3 3 0 0 3 3 3 0 TSG101 and ALIX binding domain of CEP55 Alpha-mann_mid PF09261.11 ETO03536.1 - 0.15 12.2 0.5 9.4 6.5 0.1 3.5 2 1 1 3 3 3 0 Alpha mannosidase middle domain Ku_PK_bind PF08785.11 ETO03536.1 - 0.26 11.4 8.0 3.6 7.8 0.1 5.4 2 1 2 4 4 4 0 Ku C terminal domain like ENTH PF01417.20 ETO03536.1 - 0.29 11.2 11.2 8.5 6.4 0.0 5.6 4 1 3 7 7 7 0 ENTH domain Spore_Cse60 PF10957.8 ETO03536.1 - 0.35 10.9 8.9 18 5.4 0.1 5.3 5 1 0 5 5 4 0 Sporulation protein Cse60 Activator-TraM PF11657.8 ETO03536.1 - 0.54 10.1 4.3 0.3 10.9 0.2 2.7 3 0 0 3 3 3 0 Transcriptional activator TraM Spore_III_AB PF09548.10 ETO03536.1 - 0.7 10.0 15.9 0.26 11.4 1.5 4.5 2 1 0 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) DUF3349 PF11829.8 ETO03536.1 - 4.3 8.2 12.7 14 6.5 0.2 6.2 5 1 5 10 10 9 0 Protein of unknown function (DUF3349) Anticodon_1 PF08264.13 ETO03536.1 - 5.2 7.0 7.8 2.7 7.9 0.0 3.8 5 0 0 5 5 4 0 Anticodon-binding domain of tRNA DUF4428 PF14471.6 ETO03536.1 - 5.6 7.0 8.2 2.9 7.9 0.6 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4428) DUF2312 PF10073.9 ETO03537.1 - 0.07 12.8 0.9 0.51 10.0 0.1 2.3 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) FmiP_Thoc5 PF09766.9 ETO03538.1 - 0.0015 17.9 4.0 0.013 14.8 0.3 2.2 2 0 0 2 2 2 2 Fms-interacting protein/Thoc5 7TMR-HDED PF07697.11 ETO03538.1 - 0.08 13.1 1.7 0.24 11.5 1.7 1.7 1 1 0 1 1 1 0 7TM-HD extracellular TBCA PF02970.16 ETO03541.1 - 0.00019 21.7 0.3 0.16 12.3 0.0 3.1 2 0 0 2 2 2 2 Tubulin binding cofactor A BAR_3_WASP_bdg PF10456.9 ETO03541.1 - 0.0016 18.0 6.1 0.0067 15.9 0.3 2.7 2 1 1 3 3 3 2 WASP-binding domain of Sorting nexin protein Tox-MPTase4 PF15640.6 ETO03541.1 - 0.15 12.0 5.5 1.6 8.6 0.1 3.5 4 0 0 4 4 4 0 Metallopeptidase toxin 4 CAP_N PF01213.19 ETO03541.1 - 0.34 10.3 3.1 0.18 11.3 0.4 1.8 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Mt_ATP-synt_D PF05873.12 ETO03541.1 - 4.7 7.0 8.5 2.1 8.2 0.2 3.4 1 1 3 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) TelA PF05816.11 ETO03543.1 - 0.056 12.5 0.2 0.066 12.3 0.2 1.1 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) DUF2540 PF10802.8 ETO03544.1 - 0.048 13.7 0.9 0.1 12.7 0.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2540) Fer2_4 PF13510.6 ETO03546.1 - 0.067 13.2 0.0 0.087 12.9 0.0 1.1 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain WD40 PF00400.32 ETO03547.1 - 3.7e-43 144.7 25.6 1e-07 32.5 0.1 8.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03547.1 - 4.9e-13 49.2 0.1 0.0077 16.5 0.0 5.9 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03547.1 - 1.3e-09 37.3 14.3 0.0012 17.6 0.6 5.9 2 1 0 5 5 5 4 Nucleoporin Nup120/160 PKcGMP_CC PF16808.5 ETO03547.1 - 0.0011 18.8 2.5 0.044 13.7 1.4 2.9 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase PigN PF04987.14 ETO03547.1 - 0.11 11.4 3.2 0.16 10.8 3.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) DUF4349 PF14257.6 ETO03547.1 - 0.31 10.5 4.5 0.094 12.2 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Exonuc_VII_L PF02601.15 ETO03547.1 - 1 8.8 14.7 1.7 8.2 14.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Methyltransf_12 PF08242.12 ETO03547.1 - 1.4 9.7 3.9 2.2 9.1 0.5 2.8 2 0 0 2 2 2 0 Methyltransferase domain Serinc PF03348.15 ETO03547.1 - 2.4 7.0 6.2 0.3 10.0 1.8 1.6 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF4140 PF13600.6 ETO03547.1 - 2.5 8.6 9.2 1.2 9.7 1.0 2.6 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.12 ETO03547.1 - 2.9 8.0 14.1 0.38 10.8 4.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2968 PF11180.8 ETO03547.1 - 5 6.7 16.7 3 7.4 2.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) YojJ PF10372.9 ETO03547.1 - 8.2 6.6 9.7 0.63 10.2 0.6 2.9 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus PPR_2 PF13041.6 ETO03548.1 - 1.5e-05 25.1 2.9 0.068 13.4 0.1 2.4 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 ETO03548.1 - 0.00016 21.7 0.1 0.00051 20.1 0.0 1.9 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR PF01535.20 ETO03548.1 - 0.0034 17.5 0.1 2.6 8.5 0.0 2.6 2 0 0 2 2 2 2 PPR repeat Vasohibin PF14822.6 ETO03549.1 - 0.00066 19.0 0.8 0.00073 18.8 0.8 1.0 1 0 0 1 1 1 1 Vasohibin ASFV_p27 PF06556.11 ETO03552.1 - 0.058 13.5 0.5 0.12 12.5 0.1 1.6 2 0 0 2 2 2 0 IAP-like protein p27 C-terminus PPR_2 PF13041.6 ETO03553.1 - 0.0065 16.7 0.9 0.01 16.0 0.2 1.7 2 0 0 2 2 2 1 PPR repeat family WD40 PF00400.32 ETO03554.1 - 0.016 16.1 0.7 0.042 14.7 0.2 2.1 2 1 0 2 2 2 0 WD domain, G-beta repeat DUF5024 PF16427.5 ETO03555.1 - 0.022 15.1 1.5 0.042 14.2 0.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5024) NusB PF01029.18 ETO03555.1 - 0.035 14.4 1.8 0.091 13.0 1.8 1.6 1 1 0 1 1 1 0 NusB family DUF588 PF04535.12 ETO03556.1 - 0.011 15.5 0.0 0.015 15.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF588) Mannitol_dh PF01232.23 ETO03557.1 - 0.0061 16.7 0.6 0.01 16.0 0.4 1.5 1 1 0 1 1 1 1 Mannitol dehydrogenase Rossmann domain Pox_RNA_Pol_19 PF05320.12 ETO03557.1 - 8.8 6.3 15.5 2.3 8.2 11.6 1.9 1 1 1 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF4775 PF16001.5 ETO03557.1 - 9.3 5.5 20.1 5.3 6.4 18.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4775) Nbl1_Borealin_N PF10444.9 ETO03558.1 - 0.068 12.8 0.6 0.27 10.9 0.4 2.1 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal BT1 PF03092.16 ETO03559.1 - 0.13 10.4 0.3 0.14 10.4 0.3 1.0 1 0 0 1 1 1 0 BT1 family HEAT PF02985.22 ETO03560.1 - 2.1e-18 64.8 2.0 0.5 10.8 0.0 11.0 12 0 0 12 12 11 3 HEAT repeat HEAT_2 PF13646.6 ETO03560.1 - 8.8e-13 48.5 0.0 2e-05 24.9 0.0 7.6 6 1 2 8 8 8 1 HEAT repeats HEAT_EZ PF13513.6 ETO03560.1 - 2.6e-09 37.4 0.0 0.028 14.9 0.0 6.7 7 0 0 7 7 7 2 HEAT-like repeat Ank_4 PF13637.6 ETO03560.1 - 0.0017 18.9 0.1 0.0096 16.5 0.1 2.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) RTP1_C1 PF10363.9 ETO03560.1 - 0.0021 18.2 34.3 0.059 13.6 0.6 9.3 6 3 3 9 9 9 2 Required for nuclear transport of RNA pol II C-terminus 1 Ank_5 PF13857.6 ETO03560.1 - 0.017 15.5 0.1 0.055 13.8 0.1 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO03560.1 - 0.021 15.4 1.3 0.62 10.7 0.0 4.1 4 0 0 4 4 4 0 Ankyrin repeats (3 copies) Gluconate_2-dh3 PF13618.6 ETO03560.1 - 0.039 14.2 0.0 0.83 9.9 0.0 3.3 4 0 0 4 4 4 0 Gluconate 2-dehydrogenase subunit 3 Vac14_Fab1_bd PF12755.7 ETO03560.1 - 0.068 13.8 0.2 0.068 13.8 0.2 8.5 6 2 3 10 10 10 0 Vacuolar 14 Fab1-binding region Ank PF00023.30 ETO03560.1 - 0.069 13.6 0.1 0.36 11.4 0.1 2.4 1 0 0 1 1 1 0 Ankyrin repeat N_Asn_amidohyd PF14736.6 ETO03560.1 - 0.12 11.5 1.3 2.6 7.1 0.2 2.8 1 1 1 2 2 2 0 Protein N-terminal asparagine amidohydrolase F-box_4 PF15966.5 ETO03560.1 - 0.25 11.2 4.6 1.6 8.6 0.1 4.0 3 0 0 3 3 3 0 F-box DHDPS PF00701.22 ETO03561.1 - 0.19 10.4 0.2 0.23 10.1 0.2 1.1 1 0 0 1 1 1 0 Dihydrodipicolinate synthetase family Tubulin PF00091.25 ETO03563.1 - 2.6e-25 89.8 0.0 1.6e-24 87.2 0.0 1.7 1 1 1 2 2 2 1 Tubulin/FtsZ family, GTPase domain Lipase_3 PF01764.25 ETO03563.1 - 0.0027 17.6 0.0 0.0038 17.1 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 ETO03563.1 - 0.068 12.4 0.0 0.099 11.9 0.0 1.4 1 1 0 1 1 1 0 Serine aminopeptidase, S33 WD40 PF00400.32 ETO03564.1 - 1.9e-35 120.3 14.2 2.9e-08 34.2 0.6 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO03564.1 - 1.7e-08 33.9 1.1 3.3e-08 33.0 1.1 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) ANAPC4_WD40 PF12894.7 ETO03564.1 - 2.2e-07 31.1 0.5 0.053 13.8 0.1 3.6 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03564.1 - 1.5e-06 27.4 0.6 0.59 9.0 0.0 3.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide_4 PF13599.6 ETO03564.1 - 3.5e-05 23.9 0.2 8.1e-05 22.7 0.2 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nup160 PF11715.8 ETO03564.1 - 0.00082 18.1 2.2 0.39 9.3 0.2 2.7 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Pentapeptide_3 PF13576.6 ETO03564.1 - 0.001 19.2 0.6 0.0022 18.1 0.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) WD40_like PF17005.5 ETO03564.1 - 0.0062 15.9 4.8 0.64 9.3 0.0 2.5 3 0 0 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO03564.1 - 0.031 12.8 0.5 0.086 11.4 0.4 1.6 1 1 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO03564.1 - 0.037 14.0 4.7 0.45 10.5 0.1 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat LytR_cpsA_psr PF03816.14 ETO03564.1 - 0.23 11.6 0.8 4.1 7.6 0.1 2.9 2 1 1 3 3 3 0 Cell envelope-related transcriptional attenuator domain Crust_neurohorm PF01147.17 ETO03565.1 - 0.0043 16.9 1.0 0.0066 16.2 1.0 1.4 1 0 0 1 1 1 1 Crustacean CHH/MIH/GIH neurohormone family WD40 PF00400.32 ETO03566.1 - 2.4e-15 56.6 8.6 8.3e-06 26.4 0.0 5.1 4 2 0 4 4 4 3 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO03566.1 - 3.4e-06 27.6 3.7 1.6e-05 25.5 3.7 2.2 1 0 0 1 1 1 1 TRAF-type zinc finger DUF4973 PF16343.5 ETO03566.1 - 0.006 16.6 0.1 0.013 15.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4973) ANAPC4_WD40 PF12894.7 ETO03566.1 - 0.013 15.8 0.1 0.53 10.6 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain zinc_ribbon_15 PF17032.5 ETO03566.1 - 5.1 7.9 14.7 2 9.2 1.9 3.2 3 0 0 3 3 3 0 zinc-ribbon family Qua1 PF16274.5 ETO03566.1 - 8.9 6.2 6.5 4.4 7.2 1.1 2.8 3 0 0 3 3 3 0 Qua1 domain DUF918 PF06033.11 ETO03567.1 - 0.0076 16.3 2.9 0.011 15.8 2.9 1.1 1 0 0 1 1 1 1 Nucleopolyhedrovirus protein of unknown function (DUF918) UCH PF00443.29 ETO03568.1 - 1.6e-05 24.5 0.1 5.8e-05 22.7 0.0 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase TPR_12 PF13424.6 ETO03569.1 - 1.3e-121 397.1 15.1 1.4e-22 79.8 0.4 6.1 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03569.1 - 1.3e-72 237.9 0.0 1.4e-10 40.7 0.0 8.0 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03569.1 - 1e-57 188.0 5.2 1.1e-08 34.5 0.0 8.1 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03569.1 - 6.4e-52 171.4 48.2 1.1e-08 34.5 0.4 8.2 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03569.1 - 2.1e-39 130.4 50.1 1.5e-06 27.9 1.0 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03569.1 - 4.6e-33 110.7 36.8 1e-05 25.3 0.2 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03569.1 - 5.5e-26 89.0 15.8 0.0016 18.7 0.0 9.1 7 2 1 8 8 8 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03569.1 - 5.2e-23 81.4 0.0 0.015 15.9 0.0 7.0 4 3 3 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03569.1 - 4.5e-14 52.0 0.0 0.83 10.6 0.0 7.5 6 2 2 8 8 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03569.1 - 3.6e-12 46.1 1.0 1.7 9.5 0.0 7.6 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO03569.1 - 2.2e-11 44.1 0.3 0.68 10.5 0.0 5.4 2 1 3 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO03569.1 - 1.5e-10 41.0 0.0 0.0053 16.2 0.0 3.0 1 1 2 3 3 3 3 MalT-like TPR region MIT PF04212.18 ETO03569.1 - 2.2e-10 40.5 27.8 0.0031 17.5 0.1 7.3 8 0 0 8 8 8 3 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO03569.1 - 5.9e-09 35.9 22.7 0.14 12.0 0.1 7.0 1 1 6 7 7 7 4 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO03569.1 - 4.4e-08 33.2 14.3 0.1 12.8 0.5 5.4 1 1 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 SNAP PF14938.6 ETO03569.1 - 1.2e-07 31.5 7.0 0.0027 17.2 0.7 3.6 1 1 3 4 4 4 4 Soluble NSF attachment protein, SNAP TPR_3 PF07720.12 ETO03569.1 - 4.3e-06 26.6 36.1 0.0069 16.4 0.8 7.5 8 0 0 8 8 8 3 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO03569.1 - 9.2e-06 25.1 12.6 8.2 6.1 0.1 8.3 8 1 0 8 8 8 0 Helix-turn-helix bacterial domain TPR_11 PF13414.6 ETO03569.1 - 3.6e-05 23.4 50.8 0.23 11.2 1.2 11.8 10 4 4 14 14 14 4 TPR repeat DUF4810 PF16068.5 ETO03569.1 - 0.0009 19.7 9.7 9.3 6.9 0.2 5.6 4 2 1 5 5 5 0 Domain of unknown function (DUF4810) PPR PF01535.20 ETO03569.1 - 0.00096 19.3 16.2 3.5 8.1 0.2 6.9 7 0 0 7 7 7 1 PPR repeat Vac_Fusion PF02346.16 ETO03569.1 - 0.001 18.6 0.0 20 4.9 0.0 4.8 5 0 0 5 5 5 0 Chordopoxvirus multifunctional envelope protein A27 TPR_9 PF13371.6 ETO03569.1 - 0.0028 17.7 0.0 6 7.1 0.0 4.0 1 1 4 6 6 6 0 Tetratricopeptide repeat TPR_5 PF12688.7 ETO03569.1 - 0.0043 17.3 0.0 2 8.7 0.0 3.6 2 1 2 4 4 4 1 Tetratrico peptide repeat DUF627 PF04781.12 ETO03569.1 - 0.015 15.3 8.6 60 3.7 0.0 5.8 3 1 2 6 6 6 0 Protein of unknown function (DUF627) RPN7 PF10602.9 ETO03569.1 - 0.018 14.8 10.9 4.8 6.9 0.6 5.2 1 1 3 5 5 5 0 26S proteasome subunit RPN7 bMG1 PF17970.1 ETO03569.1 - 0.073 13.1 0.0 4.8 7.3 0.0 3.5 2 2 2 4 4 4 0 Bacterial Alpha-2-macroglobulin MG1 domain DUF2777 PF10949.8 ETO03569.1 - 0.1 12.3 1.5 21 4.7 0.0 4.1 3 2 0 5 5 5 0 Protein of unknown function (DUF2777) Triabin PF03973.13 ETO03569.1 - 0.15 11.9 2.2 0.56 10.1 0.1 2.7 1 1 1 3 3 3 0 Triabin UFC1 PF08694.11 ETO03569.1 - 0.16 11.6 1.2 17 5.0 0.1 3.5 2 2 2 5 5 5 0 Ubiquitin-fold modifier-conjugating enzyme 1 Sel1 PF08238.12 ETO03569.1 - 0.33 11.7 16.5 8.8 7.2 0.1 7.1 7 2 0 7 7 7 0 Sel1 repeat bPH_3 PF14470.6 ETO03569.1 - 0.34 11.3 4.3 32 5.0 0.1 4.0 1 1 4 6 6 6 0 Bacterial PH domain BAR_3 PF16746.5 ETO03569.1 - 0.66 9.6 9.7 28 4.3 0.0 4.9 4 1 1 5 5 5 0 BAR domain of APPL family FlaE PF07559.14 ETO03569.1 - 1.2 9.7 5.8 17 6.0 2.4 2.9 2 1 0 2 2 2 0 Flagellar basal body protein FlaE Fis1_TPR_C PF14853.6 ETO03569.1 - 6.5 6.9 23.3 28 4.9 0.2 7.0 8 0 0 8 8 7 0 Fis1 C-terminal tetratricopeptide repeat TGFb_propeptide PF00688.18 ETO03571.1 - 0.023 14.4 0.3 0.025 14.3 0.3 1.2 1 0 0 1 1 1 0 TGF-beta propeptide STT3 PF02516.14 ETO03571.1 - 0.067 12.1 0.4 0.072 12.0 0.4 1.0 1 0 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit CENP-B_dimeris PF09026.10 ETO03572.1 - 0.043 14.2 8.4 0.075 13.4 8.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain La PF05383.17 ETO03573.1 - 6.6e-14 51.7 0.0 1.3e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 La domain DUF2312 PF10073.9 ETO03573.1 - 0.078 12.6 1.2 0.078 12.6 1.2 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) GMP_PDE_delta PF05351.11 ETO03573.1 - 0.12 12.5 0.1 0.14 12.2 0.1 1.1 1 0 0 1 1 1 0 GMP-PDE, delta subunit CC2-LZ PF16516.5 ETO03573.1 - 0.76 10.2 7.1 1.1 9.6 4.1 2.4 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FlxA PF14282.6 ETO03573.1 - 4.6 7.3 6.3 18 5.4 6.3 2.1 1 1 0 1 1 1 0 FlxA-like protein Nucleoporin2 PF04096.14 ETO03574.1 - 4.5e-42 143.7 0.0 8.7e-42 142.7 0.0 1.5 1 0 0 1 1 1 1 Nucleoporin autopeptidase Trypan_PARP PF05887.11 ETO03576.1 - 0.24 11.4 6.0 0.47 10.4 6.0 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4746 PF15928.5 ETO03576.1 - 0.3 10.5 8.9 0.37 10.2 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SLC12 PF03522.15 ETO03576.1 - 0.46 9.5 11.9 0.66 8.9 11.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF2981 PF11200.8 ETO03576.1 - 1.9 8.2 9.1 2.5 7.8 9.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Presenilin PF01080.17 ETO03576.1 - 6.6 5.4 11.2 8.6 5.0 11.2 1.3 1 0 0 1 1 1 0 Presenilin DUF2457 PF10446.9 ETO03578.1 - 0.66 9.1 24.7 0.13 11.4 21.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Menin PF05053.13 ETO03578.1 - 7.8 4.7 18.1 15 3.8 14.8 2.2 2 0 0 2 2 2 0 Menin MMR_HSR1 PF01926.23 ETO03579.1 - 5.6e-06 26.4 1.3 1.1e-05 25.4 0.1 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase AIG1 PF04548.16 ETO03579.1 - 0.0012 18.2 1.5 0.0012 18.2 1.5 3.6 3 1 0 3 3 3 1 AIG1 family ABC_tran PF00005.27 ETO03579.1 - 0.0069 16.9 1.0 0.024 15.2 0.3 2.4 1 1 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 ETO03579.1 - 0.015 15.3 0.0 0.064 13.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO03579.1 - 0.015 15.7 0.2 0.044 14.2 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ETO03579.1 - 0.018 14.8 0.1 0.039 13.7 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 ETO03579.1 - 0.018 14.8 0.1 0.1 12.4 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 ETO03579.1 - 0.033 14.1 5.9 0.64 9.9 5.8 2.6 1 1 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ETO03579.1 - 0.033 14.5 0.1 0.27 11.5 0.0 2.5 3 0 0 3 3 3 0 AAA domain T2SSE PF00437.20 ETO03579.1 - 0.052 12.6 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ETO03579.1 - 0.083 12.2 0.4 0.19 11.1 0.4 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family Dynamin_N PF00350.23 ETO03579.1 - 0.15 12.1 10.5 0.091 12.8 7.0 2.3 2 1 0 2 2 2 0 Dynamin family Hydrolase_3 PF08282.12 ETO03579.1 - 5.2 6.7 12.7 4.4 7.0 6.5 3.1 1 1 2 3 3 3 0 haloacid dehalogenase-like hydrolase O-antigen_lig PF13425.6 ETO03580.1 - 0.06 12.1 6.6 0.073 11.9 6.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3987 PF13148.6 ETO03580.1 - 0.26 10.3 5.6 0.32 10.0 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RNA_pol_Rpb1_5 PF04998.17 ETO03580.1 - 0.35 10.3 2.7 0.38 10.1 2.7 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Presenilin PF01080.17 ETO03580.1 - 3 6.5 5.4 3.5 6.3 5.4 1.1 1 0 0 1 1 1 0 Presenilin HEAT PF02985.22 ETO03581.1 - 1.4e-13 49.8 0.2 0.00048 20.2 0.0 7.1 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.6 ETO03581.1 - 2.5e-12 47.0 0.0 0.00015 22.1 0.0 5.0 2 1 4 6 6 6 2 HEAT repeats HEAT_EZ PF13513.6 ETO03581.1 - 4.3e-08 33.5 0.0 0.054 14.0 0.0 5.0 6 0 0 6 6 6 2 HEAT-like repeat Cnd1 PF12717.7 ETO03581.1 - 5.1e-06 26.6 14.1 0.0031 17.6 0.1 4.3 1 1 3 4 4 4 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETO03581.1 - 0.0002 21.5 8.1 0.15 12.3 0.0 5.3 1 1 3 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO03581.1 - 0.00072 20.1 5.7 0.73 10.5 0.0 5.0 1 1 5 6 6 6 2 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO03581.1 - 0.0017 18.2 8.3 1.3 8.8 0.1 4.5 1 1 2 3 3 3 2 TATA-binding protein interacting (TIP20) DUF5063 PF16702.5 ETO03581.1 - 0.0045 17.4 0.9 6.2 7.2 0.1 3.4 2 2 1 3 3 3 2 Domain of unknown function (DUF5063) HEAT_PBS PF03130.16 ETO03581.1 - 0.017 15.7 0.0 50 5.0 0.0 4.5 6 0 0 6 6 3 0 PBS lyase HEAT-like repeat Syntaphilin PF15290.6 ETO03581.1 - 0.02 14.5 1.8 0.8 9.3 0.1 3.0 1 1 2 3 3 3 0 Golgi-localised syntaxin-1-binding clamp NLE PF08154.12 ETO03581.1 - 0.069 13.7 12.7 4.5 7.9 0.0 5.1 6 1 0 7 7 5 0 NLE (NUC135) domain ENTH PF01417.20 ETO03581.1 - 0.11 12.5 4.7 1.1 9.4 0.0 3.5 3 1 0 4 4 4 0 ENTH domain Syndecan PF01034.20 ETO03581.1 - 0.12 12.4 0.0 0.33 10.9 0.0 1.8 1 0 0 1 1 1 0 Syndecan domain DUF3349 PF11829.8 ETO03581.1 - 0.32 11.8 4.5 1.1e+02 3.7 0.1 4.4 2 1 2 4 4 4 0 Protein of unknown function (DUF3349) DDE_Tnp_ISL3 PF01610.17 ETO03581.1 - 0.36 10.5 4.3 0.74 9.5 0.3 2.7 2 2 1 3 3 3 0 Transposase Spore_III_AB PF09548.10 ETO03581.1 - 2.2 8.3 11.9 1.9 8.5 0.2 4.2 1 1 3 4 4 4 0 Stage III sporulation protein AB (spore_III_AB) Spore_Cse60 PF10957.8 ETO03581.1 - 4.3 7.4 9.5 47 4.1 0.1 5.4 5 0 0 5 5 5 0 Sporulation protein Cse60 BCS1_N PF08740.11 ETO03583.1 - 0.0019 18.2 0.1 0.0022 18.0 0.1 1.1 1 0 0 1 1 1 1 BCS1 N terminal Kelch_6 PF13964.6 ETO03587.1 - 0.00019 21.6 0.4 0.0028 17.9 0.1 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO03587.1 - 0.0015 18.1 0.0 0.028 14.0 0.0 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO03587.1 - 0.13 12.3 1.4 1.5 8.9 0.1 3.2 3 2 0 3 3 3 0 Kelch motif Pro-rich_19 PF15455.6 ETO03588.1 - 0.003 16.8 0.2 0.003 16.8 0.2 1.5 2 0 0 2 2 2 1 Proline-rich 19 Phage_GP20 PF06810.11 ETO03588.1 - 0.014 15.2 16.8 0.014 15.2 16.8 3.0 1 1 2 3 3 3 0 Phage minor structural protein GP20 CCDC158 PF15921.5 ETO03588.1 - 0.016 13.1 20.6 0.02 12.8 20.6 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 158 TPR_MLP1_2 PF07926.12 ETO03588.1 - 0.034 14.2 30.1 0.057 13.5 10.7 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein UPF0242 PF06785.11 ETO03588.1 - 0.07 13.2 41.4 0.61 10.2 24.6 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Fez1 PF06818.15 ETO03588.1 - 0.15 12.5 29.2 0.24 11.8 29.1 1.4 1 1 0 1 1 1 0 Fez1 Lebercilin PF15619.6 ETO03588.1 - 0.17 11.5 36.7 0.029 14.0 23.2 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Golgin_A5 PF09787.9 ETO03588.1 - 0.68 9.3 32.8 1.8 7.9 32.8 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 YabA PF06156.13 ETO03588.1 - 1.1 10.0 32.0 1.2 9.9 11.7 2.5 1 1 1 2 2 2 0 Initiation control protein YabA Jnk-SapK_ap_N PF09744.9 ETO03588.1 - 1.8 8.8 35.4 9.5 6.4 11.9 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 OsmC PF02566.19 ETO03588.1 - 1.9 9.0 4.9 0.52 10.8 0.7 2.0 2 1 0 2 2 2 0 OsmC-like protein Tropomyosin_1 PF12718.7 ETO03588.1 - 3.7 7.7 37.2 17 5.5 13.0 2.7 1 1 1 2 2 2 0 Tropomyosin like Fib_alpha PF08702.10 ETO03588.1 - 5.8 7.1 35.4 13 5.9 18.1 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Hemagglutinin PF00509.18 ETO03588.1 - 6.3 5.1 15.8 4.4 5.6 14.0 1.4 1 1 0 1 1 1 0 Haemagglutinin V_ATPase_I PF01496.19 ETO03588.1 - 6.5 4.5 22.7 9.1 4.1 22.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FlaC_arch PF05377.11 ETO03588.1 - 6.6 7.2 23.6 2 8.9 7.2 3.8 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) LA-virus_coat PF09220.10 ETO03589.1 - 0.025 13.2 0.0 0.033 12.8 0.0 1.1 1 0 0 1 1 1 0 L-A virus, major coat protein Cluap1 PF10234.9 ETO03590.1 - 6.4e-67 225.8 16.2 1.2e-48 165.9 0.5 2.5 2 1 0 2 2 2 2 Clusterin-associated protein-1 RibD_C PF01872.17 ETO03590.1 - 0.066 13.0 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 RibD C-terminal domain Nfu_N PF08712.11 ETO03590.1 - 0.068 13.2 0.2 0.4 10.8 0.0 2.4 2 0 0 2 2 2 0 Scaffold protein Nfu/NifU N terminal Ish1 PF10281.9 ETO03590.1 - 0.096 13.0 2.4 0.28 11.5 2.4 1.8 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein ArfGap PF01412.18 ETO03590.1 - 0.19 11.8 3.2 0.66 10.1 3.2 1.9 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf ER-remodelling PF14755.6 ETO03590.1 - 2.8 8.2 4.8 5.7 7.2 4.8 1.4 1 0 0 1 1 1 0 Intracellular membrane remodeller HSP70 PF00012.20 ETO03591.1 - 3.8e-13 48.5 4.2 3.8e-13 48.5 4.2 2.8 2 1 0 2 2 2 1 Hsp70 protein CBP_BcsG PF11658.8 ETO03591.1 - 0.21 10.0 0.0 0.21 10.0 0.0 2.4 3 0 0 3 3 3 0 Cellulose biosynthesis protein BcsG Peptidase_U57 PF05582.12 ETO03591.1 - 0.37 10.0 9.6 0.15 11.3 3.2 2.4 2 0 0 2 2 2 0 YabG peptidase U57 TLP-20 PF06088.11 ETO03591.1 - 2.6 7.9 13.6 1.4 8.8 6.3 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF4890 PF16231.5 ETO03591.1 - 9.3 6.8 15.1 0.44 11.1 0.6 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4890) HSP70 PF00012.20 ETO03592.1 - 3.4e-29 101.5 0.3 4.2e-29 101.2 0.3 1.0 1 0 0 1 1 1 1 Hsp70 protein DUF4047 PF13256.6 ETO03592.1 - 0.097 12.9 0.1 0.14 12.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) Ribosomal_S4 PF00163.19 ETO03593.1 - 3e-07 31.2 3.0 6.6e-07 30.2 2.7 1.8 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain S4 PF01479.25 ETO03593.1 - 3.1e-06 26.8 0.7 3.1e-06 26.8 0.7 1.9 2 0 0 2 2 2 1 S4 domain OATP PF03137.20 ETO03593.1 - 0.031 12.6 0.1 0.035 12.4 0.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Orthopox_F6 PF06601.12 ETO03593.1 - 0.043 14.0 1.0 0.094 12.9 1.0 1.5 1 0 0 1 1 1 0 Orthopoxvirus F6 protein Spore_YhcN_YlaJ PF09580.10 ETO03593.1 - 0.047 13.8 0.1 0.089 12.9 0.1 1.4 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) DUF21 PF01595.20 ETO03594.1 - 1.1 9.0 8.9 0.062 13.0 1.7 2.0 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain RGS PF00615.19 ETO03595.1 - 0.00025 21.3 5.8 0.0022 18.2 0.6 2.5 2 2 0 2 2 2 2 Regulator of G protein signaling domain RNA_pol_Rpc4 PF05132.14 ETO03595.1 - 0.13 12.7 1.7 0.19 12.1 1.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DnaJ PF00226.31 ETO03596.1 - 2.1e-16 59.8 2.2 3.8e-16 59.0 2.2 1.4 1 0 0 1 1 1 1 DnaJ domain eIF-3_zeta PF05091.12 ETO03597.1 - 0.62 9.0 6.1 0.72 8.8 6.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) Ly49 PF08391.10 ETO03597.1 - 1.6 9.1 6.5 0.38 11.1 1.2 2.3 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region Spc24 PF08286.11 ETO03597.1 - 1.7 9.0 6.3 2.4 8.4 6.1 1.6 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF4407 PF14362.6 ETO03597.1 - 2.3 7.5 7.5 2.7 7.3 7.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) OrfB_IS605 PF01385.19 ETO03597.1 - 4.7 7.5 8.5 5.7e+02 0.7 8.4 2.3 1 1 0 1 1 1 0 Probable transposase GrpE PF01025.19 ETO03597.1 - 8.4 6.0 9.6 20 4.8 9.6 1.6 1 1 0 1 1 1 0 GrpE AhpC-TSA PF00578.21 ETO03598.1 - 0.026 14.4 0.2 0.039 13.9 0.2 1.3 1 0 0 1 1 1 0 AhpC/TSA family MHC_II_beta PF00969.19 ETO03598.1 - 0.069 13.3 1.3 0.09 12.9 0.7 1.6 1 1 0 1 1 1 0 Class II histocompatibility antigen, beta domain Pept_S41_N PF18294.1 ETO03600.1 - 0.0016 18.4 0.5 0.023 14.7 0.1 2.3 2 0 0 2 2 2 1 Peptidase S41 N-terminal domain CDC50 PF03381.15 ETO03601.1 - 2.8e-14 53.3 0.9 3.2e-14 53.1 0.9 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Phage_T4_gp19 PF06841.12 ETO03601.1 - 0.06 13.2 0.5 0.11 12.4 0.3 1.5 1 1 0 1 1 1 0 T4-like virus tail tube protein gp19 WD40 PF00400.32 ETO03602.1 - 1.7e-34 117.2 23.6 1.4e-06 28.9 0.6 7.4 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03602.1 - 1e-13 51.4 2.2 0.021 15.1 0.1 5.8 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03602.1 - 7.3e-09 34.8 9.8 0.011 14.4 0.3 5.1 1 1 1 5 5 5 4 Nucleoporin Nup120/160 Lyx_isomer PF07385.12 ETO03602.1 - 0.019 14.2 0.3 0.032 13.5 0.3 1.3 1 0 0 1 1 1 0 D-lyxose isomerase zf-RING_4 PF14570.6 ETO03603.1 - 6.9 6.6 13.8 1 9.2 3.9 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUP PF00674.18 ETO03604.1 - 0.024 14.8 0.2 0.033 14.3 0.2 1.2 1 0 0 1 1 1 0 DUP family CDC45 PF02724.14 ETO03604.1 - 1.7 6.8 11.9 1.7 6.9 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein MyTH4 PF00784.17 ETO03605.1 - 1.7e-23 83.1 0.5 1.7e-23 83.1 0.5 1.8 2 0 0 2 2 2 1 MyTH4 domain OSTMP1 PF09777.9 ETO03605.1 - 0.07 12.5 0.5 0.11 11.8 0.5 1.3 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor DPRP PF04244.13 ETO03606.1 - 0.083 12.7 1.9 0.68 9.7 0.4 2.2 2 0 0 2 2 2 0 Deoxyribodipyrimidine photo-lyase-related protein AbiEi_3 PF11459.8 ETO03607.1 - 0.064 12.9 0.1 0.21 11.2 0.1 1.8 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system CLU_N PF15044.6 ETO03607.1 - 0.82 10.1 0.0 0.82 10.1 0.0 3.0 4 0 0 4 4 4 0 Mitochondrial function, CLU-N-term CENP-R PF06729.12 ETO03607.1 - 1.4 8.9 9.2 0.09 12.7 2.8 2.1 2 0 0 2 2 2 0 Kinetochore component, CENP-R DIRP PF06584.13 ETO03608.1 - 0.13 12.5 0.1 18 5.6 0.0 3.0 3 0 0 3 3 3 0 DIRP hDGE_amylase PF14701.6 ETO03609.1 - 0.048 12.7 10.6 0.071 12.2 10.6 1.3 1 1 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain WD40 PF00400.32 ETO03610.1 - 9.8e-36 121.2 6.4 3.4e-10 40.3 0.0 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03610.1 - 4e-13 49.5 0.6 0.0004 20.6 0.0 3.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03610.1 - 2.2e-06 27.2 0.6 0.00046 19.6 0.2 2.2 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO03610.1 - 8.9e-05 21.3 0.1 0.48 9.0 0.0 3.8 1 1 3 4 4 4 1 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO03610.1 - 0.0011 18.0 0.3 0.21 10.5 0.0 2.9 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 ETO03610.1 - 0.0016 18.3 0.0 3.6 7.7 0.0 3.4 3 0 0 3 3 3 1 PQQ enzyme repeat DUF4221 PF13970.6 ETO03610.1 - 0.0019 17.8 0.5 0.038 13.6 0.0 2.4 1 1 2 3 3 3 1 Domain of unknown function (DUF4221) Coatomer_WDAD PF04053.14 ETO03610.1 - 0.029 13.4 0.3 0.034 13.2 0.3 1.1 1 0 0 1 1 1 0 Coatomer WD associated region DUF5449 PF17528.2 ETO03610.1 - 0.06 13.1 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5449) Arylsulfotran_2 PF14269.6 ETO03610.1 - 0.067 12.6 1.0 6.5 6.0 0.1 2.2 1 1 0 2 2 2 0 Arylsulfotransferase (ASST) NHL PF01436.21 ETO03610.1 - 0.078 13.0 0.5 21 5.4 0.1 3.3 3 0 0 3 3 3 0 NHL repeat VID27 PF08553.10 ETO03610.1 - 0.09 11.8 0.0 0.84 8.6 0.0 1.9 1 1 0 1 1 1 0 VID27 C-terminal WD40-like domain eIF-5_eIF-2B PF01873.17 ETO03611.1 - 2e-33 114.7 0.9 3.4e-33 114.0 0.9 1.3 1 0 0 1 1 1 1 Domain found in IF2B/IF5 Elf1 PF05129.13 ETO03611.1 - 0.03 14.4 0.8 0.098 12.7 0.8 1.8 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like tRNA-synt_1f PF01921.18 ETO03611.1 - 0.093 11.6 0.0 0.11 11.4 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (K) WD40 PF00400.32 ETO03612.1 - 1.7e-51 171.1 24.2 2.3e-10 40.9 0.1 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03612.1 - 4.4e-24 84.6 6.6 7.8e-06 26.1 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO03612.1 - 1.7e-12 47.3 1.0 0.00062 19.2 0.1 3.3 1 1 3 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO03612.1 - 7.1e-11 41.6 0.8 0.1 11.6 0.0 5.1 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO03612.1 - 1.7e-07 30.3 6.3 0.013 14.2 0.1 4.2 1 1 4 5 5 5 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO03612.1 - 3.7e-07 30.0 4.2 0.072 12.7 0.0 3.1 3 0 0 3 3 3 3 PQQ-like domain Cytochrom_D1 PF02239.16 ETO03612.1 - 1.6e-06 26.9 2.7 0.0087 14.6 0.2 3.3 1 1 0 3 3 3 2 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO03612.1 - 9.8e-06 24.7 0.0 0.41 9.4 0.0 3.4 1 1 2 3 3 3 3 Methylamine dehydrogenase heavy chain (MADH) DUF5570 PF17731.1 ETO03612.1 - 0.00016 21.8 4.9 0.48 10.5 0.2 4.7 2 1 3 6 6 5 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO03612.1 - 0.00057 19.7 9.3 5 7.2 0.0 6.5 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO03612.1 - 0.0017 17.4 2.4 0.63 8.9 0.3 3.8 1 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 ETO03612.1 - 0.0027 16.5 11.7 0.13 11.0 2.9 3.3 1 1 2 3 3 3 2 Nup133 N terminal like PQQ PF01011.21 ETO03612.1 - 0.0052 16.7 0.0 23 5.2 0.0 4.6 5 0 0 5 5 5 0 PQQ enzyme repeat NHL PF01436.21 ETO03612.1 - 0.0078 16.2 0.1 8.7 6.6 0.0 3.3 4 0 0 4 4 4 1 NHL repeat FlaE PF07559.14 ETO03612.1 - 0.0092 16.5 0.2 0.026 15.1 0.2 1.7 1 1 0 1 1 1 1 Flagellar basal body protein FlaE DUF2963 PF11178.8 ETO03612.1 - 2.4 7.9 11.0 24 4.7 0.0 5.0 4 1 1 5 5 5 0 Protein of unknown function (DUF2963) WD40 PF00400.32 ETO03613.1 - 1.6e-40 136.3 19.5 6.3e-10 39.5 0.1 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03613.1 - 1.6e-18 66.8 1.8 0.014 15.7 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03613.1 - 2e-10 40.1 0.1 0.00076 18.5 0.0 3.4 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO03613.1 - 3.3e-09 36.9 0.6 0.0023 17.8 0.0 3.5 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO03613.1 - 7.2e-07 29.0 1.4 11 6.1 0.0 5.5 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO03613.1 - 4.7e-06 25.5 3.7 1.8 7.1 0.0 4.5 1 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO03613.1 - 4.9e-06 26.1 4.0 0.02 14.3 0.1 2.9 1 1 2 3 3 3 3 WD40-like domain Ricin_B_lectin PF00652.22 ETO03613.1 - 3.8e-05 24.0 1.0 0.015 15.5 0.3 2.8 1 1 2 3 3 3 2 Ricin-type beta-trefoil lectin domain Cytochrom_D1 PF02239.16 ETO03613.1 - 6.2e-05 21.7 0.0 0.16 10.5 0.0 2.5 2 1 1 3 3 3 2 Cytochrome D1 heme domain Str_synth PF03088.16 ETO03613.1 - 0.00046 20.2 0.7 7.5 6.8 0.0 4.9 3 2 1 5 5 5 1 Strictosidine synthase Nucleoporin_N PF08801.11 ETO03613.1 - 0.0039 16.0 3.4 2 7.1 0.1 3.3 1 1 1 3 3 3 3 Nup133 N terminal like DUF5570 PF17731.1 ETO03613.1 - 0.0093 16.1 0.7 18 5.5 0.0 4.2 2 1 2 5 5 5 0 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO03613.1 - 0.02 14.0 1.8 0.9 8.5 0.6 2.2 1 1 1 2 2 2 0 Coatomer WD associated region PALB2_WD40 PF16756.5 ETO03613.1 - 0.024 13.6 1.4 0.49 9.3 0.2 3.0 1 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Resistin PF06954.11 ETO03613.1 - 0.37 11.4 2.4 40 4.8 0.0 3.9 2 2 1 4 4 4 0 Resistin WD40 PF00400.32 ETO03614.1 - 8.7e-56 184.6 18.7 2.1e-09 37.8 0.0 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03614.1 - 3.4e-18 65.7 2.0 0.0052 17.1 0.0 7.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO03614.1 - 2.6e-10 39.8 1.9 0.097 11.6 0.0 6.5 2 1 6 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ETO03614.1 - 0.00014 21.0 0.1 0.044 12.7 0.0 3.5 3 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ETO03614.1 - 0.00061 18.5 0.6 1.9 7.1 0.0 3.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO03614.1 - 0.00083 19.2 6.0 15 5.7 0.1 6.0 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO03614.1 - 0.00084 19.4 0.3 26 4.9 0.0 5.0 1 1 4 5 5 5 0 Family of unknown function (DUF5570) Kelch_1 PF01344.25 ETO03614.1 - 0.015 14.9 0.2 0.07 12.7 0.1 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO03614.1 - 0.019 15.0 0.1 0.25 11.4 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain PQQ_2 PF13360.6 ETO03614.1 - 0.035 13.7 0.0 0.07 12.7 0.0 1.5 1 0 0 1 1 1 0 PQQ-like domain Kelch_2 PF07646.15 ETO03614.1 - 0.23 11.5 0.8 2 8.5 0.2 3.0 2 0 0 2 2 2 0 Kelch motif Proteasome_A_N PF10584.9 ETO03614.1 - 1.5 8.5 5.4 26 4.6 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF3307 PF11750.8 ETO03615.1 - 0.0055 16.8 0.4 0.0097 16.0 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3307) Orf78 PF06024.12 ETO03615.1 - 0.0094 16.2 0.3 0.0094 16.2 0.3 1.6 2 0 0 2 2 2 1 Orf78 (ac78) DUF3464 PF11947.8 ETO03615.1 - 0.018 14.8 0.0 0.03 14.1 0.0 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 ETRAMP PF09716.10 ETO03615.1 - 0.031 14.3 0.3 0.031 14.3 0.3 1.7 2 0 0 2 2 1 0 Malarial early transcribed membrane protein (ETRAMP) Hyccin PF09790.9 ETO03615.1 - 0.04 13.0 0.1 0.067 12.3 0.1 1.4 1 0 0 1 1 1 0 Hyccin DUF2427 PF10348.9 ETO03615.1 - 0.045 13.5 0.8 0.082 12.7 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2427) SARAF PF06682.12 ETO03615.1 - 0.05 13.3 0.1 1.6 8.3 0.1 2.0 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis CrgA PF06781.12 ETO03615.1 - 0.058 13.5 0.1 0.16 12.0 0.1 1.7 1 0 0 1 1 1 0 Cell division protein CrgA DUF4448 PF14610.6 ETO03615.1 - 0.073 12.8 0.1 0.29 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) DUF4710 PF15828.5 ETO03615.1 - 0.27 11.4 3.7 0.82 9.8 3.7 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4710) Neurensin PF14927.6 ETO03615.1 - 0.46 10.2 2.3 2.1 8.1 0.1 2.3 1 1 0 2 2 2 0 Neurensin Kelch_1 PF01344.25 ETO03617.1 - 0.026 14.1 0.1 0.059 13.0 0.1 1.6 1 0 0 1 1 1 0 Kelch motif Kelch_2 PF07646.15 ETO03617.1 - 0.079 13.0 2.1 2.7 8.1 0.1 2.5 2 1 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO03617.1 - 0.083 12.9 0.4 0.3 11.1 0.1 2.1 2 1 0 2 2 2 0 Galactose oxidase, central domain Sina PF03145.16 ETO03618.1 - 0.011 15.7 0.6 0.21 11.5 0.0 1.9 1 1 1 2 2 2 0 Seven in absentia protein family CC2D2AN-C2 PF15625.6 ETO03618.1 - 0.089 12.5 0.1 0.092 12.5 0.1 1.1 1 0 0 1 1 1 0 CC2D2A N-terminal C2 domain WD40 PF00400.32 ETO03620.1 - 5e-07 30.3 1.7 1.1e-05 26.0 1.8 2.5 2 1 0 2 2 2 1 WD domain, G-beta repeat ELYS-bb PF16687.5 ETO03620.1 - 0.047 12.3 0.1 0.052 12.1 0.1 1.0 1 0 0 1 1 1 0 beta-propeller of ELYS nucleoporin ANAPC4_WD40 PF12894.7 ETO03620.1 - 0.11 12.8 0.1 0.2 12.0 0.1 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO03621.1 - 0.00012 22.7 9.8 0.00021 21.9 7.2 2.6 1 1 1 2 2 2 1 TRAF-type zinc finger UvrD-helicase PF00580.21 ETO03621.1 - 0.0048 16.5 4.8 0.0062 16.1 4.8 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain Cep57_CLD_2 PF14197.6 ETO03621.1 - 0.0093 16.0 3.9 0.03 14.4 3.9 1.8 1 0 0 1 1 1 1 Centrosome localisation domain of PPC89 GIT_CC PF16559.5 ETO03621.1 - 0.11 12.4 0.4 0.11 12.4 0.4 2.5 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 ETO03621.1 - 0.12 12.7 7.8 0.41 11.0 2.3 3.2 3 0 0 3 3 3 0 TSC-22/dip/bun family AAA_23 PF13476.6 ETO03621.1 - 0.14 12.6 7.4 0.18 12.3 7.4 1.3 1 1 0 1 1 1 0 AAA domain YabA PF06156.13 ETO03621.1 - 0.59 10.8 10.6 0.081 13.6 5.6 2.1 2 0 0 2 2 2 0 Initiation control protein YabA FapA PF03961.13 ETO03621.1 - 1.4 7.5 6.7 1.6 7.2 6.4 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A MIEAP PF16026.5 ETO03624.1 - 1e-08 35.6 0.0 1.9e-08 34.7 0.0 1.5 1 1 0 1 1 1 1 Mitochondria-eating protein Herpes_Helicase PF02689.14 ETO03624.1 - 0.16 9.8 0.0 0.21 9.5 0.0 1.1 1 0 0 1 1 1 0 Helicase Presenilin PF01080.17 ETO03625.1 - 8e-07 28.2 2.4 9.8e-07 27.9 2.4 1.1 1 0 0 1 1 1 1 Presenilin Peptidase_M50B PF13398.6 ETO03625.1 - 0.0086 15.7 5.2 0.015 14.9 5.2 1.3 1 0 0 1 1 1 1 Peptidase M50B-like DUF4131 PF13567.6 ETO03625.1 - 0.21 11.2 1.5 0.28 10.8 0.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4131) SelP_N PF04592.14 ETO03625.1 - 0.61 9.4 11.2 1.1 8.6 11.2 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Spt20 PF12090.8 ETO03625.1 - 1.4 8.5 11.3 2.5 7.7 11.3 1.4 1 0 0 1 1 1 0 Spt20 family DUF4436 PF14494.6 ETO03625.1 - 3.1 7.0 6.0 0.48 9.7 2.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4436) Kelch_6 PF13964.6 ETO03627.1 - 0.11 12.9 0.1 13 6.2 0.0 2.1 1 1 1 2 2 2 0 Kelch motif L_lactis_ph-MCP PF06673.11 ETO03627.1 - 0.86 8.5 3.8 1.1 8.2 3.8 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein Peptidase_S41 PF03572.18 ETO03628.1 - 0.0034 17.0 0.1 0.0049 16.5 0.1 1.5 1 1 0 1 1 1 1 Peptidase family S41 RRM_3 PF08777.11 ETO03628.1 - 0.047 13.7 3.5 0.068 13.2 0.0 2.3 2 1 0 2 2 2 0 RNA binding motif DUF2431 PF10354.9 ETO03628.1 - 0.067 13.5 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2431) Raf1_N PF18578.1 ETO03628.1 - 0.09 13.3 0.6 0.47 11.0 0.0 2.2 1 1 1 2 2 2 0 Rubisco accumulation factor 1 alpha helical domain PapB PF03333.13 ETO03628.1 - 0.095 12.7 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Adhesin biosynthesis transcription regulatory protein YflT PF11181.8 ETO03628.1 - 0.12 12.9 0.7 0.29 11.7 0.2 1.9 2 1 0 2 2 2 0 Heat induced stress protein YflT IBR PF01485.21 ETO03629.1 - 2.5e-07 30.8 26.0 0.00016 21.8 6.1 3.0 2 1 0 2 2 2 2 IBR domain, a half RING-finger domain zf-ACC PF17848.1 ETO03629.1 - 0.1 12.7 0.1 0.1 12.7 0.1 4.8 4 2 1 5 5 5 0 Acetyl-coA carboxylase zinc finger domain La PF05383.17 ETO03630.1 - 1.4e-07 31.4 0.0 2.7e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 La domain Cofac_haem_bdg PF04187.13 ETO03630.1 - 0.04 13.9 2.2 0.045 13.7 2.2 1.1 1 0 0 1 1 1 0 Haem-binding uptake, Tiki superfamily, ChaN Neur_chan_memb PF02932.16 ETO03630.1 - 0.9 9.6 2.8 1.1 9.2 2.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO03630.1 - 6 5.5 8.7 6.7 5.4 8.7 1.1 1 0 0 1 1 1 0 Presenilin VWA_2 PF13519.6 ETO03631.1 - 3.1e-05 24.6 0.0 5.6e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO03631.1 - 0.028 14.7 0.0 0.061 13.6 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain SepSecS PF05889.13 ETO03631.1 - 0.072 11.8 0.1 0.093 11.4 0.1 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS PPR PF01535.20 ETO03632.1 - 9.6e-18 63.1 3.5 0.00017 21.6 0.1 4.5 4 0 0 4 4 4 4 PPR repeat PPR_2 PF13041.6 ETO03632.1 - 9e-15 54.6 11.9 2.3e-08 34.1 0.3 4.6 3 1 2 5 5 5 4 PPR repeat family PPR_3 PF13812.6 ETO03632.1 - 1.6e-13 50.5 1.3 1.4e-05 25.0 0.0 4.9 2 1 3 5 5 5 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO03632.1 - 2.8e-11 42.9 4.6 0.00041 20.0 0.0 4.4 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 ETO03632.1 - 2.9e-08 33.3 0.0 4.1e-08 32.9 0.0 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF3636 PF12331.8 ETO03632.1 - 0.029 14.2 0.1 0.046 13.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) ATP13 PF12921.7 ETO03632.1 - 0.042 13.7 0.5 0.31 10.9 0.1 2.6 2 1 1 3 3 3 0 Mitochondrial ATPase expression CENP-B_dimeris PF09026.10 ETO03633.1 - 0.00013 22.3 17.3 0.00013 22.3 17.3 1.9 2 0 0 2 2 2 1 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ETO03633.1 - 0.028 14.1 41.5 0.038 13.7 41.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CNDH2_C PF16858.5 ETO03633.1 - 0.11 12.4 25.0 0.13 12.2 25.0 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC27 PF09507.10 ETO03633.1 - 0.13 11.6 38.0 0.15 11.4 38.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ETO03633.1 - 0.79 7.9 35.6 0.91 7.7 35.6 1.0 1 0 0 1 1 1 0 Nop14-like family Nop25 PF09805.9 ETO03633.1 - 1.3 9.5 39.9 1.5 9.3 39.9 1.0 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) SWIRM-assoc_2 PF16496.5 ETO03633.1 - 1.4 7.7 30.3 1.7 7.4 30.3 1.2 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal FAM60A PF15396.6 ETO03633.1 - 7.6 6.5 24.7 12 5.8 24.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Glyco_hydro_47 PF01532.20 ETO03634.1 - 4.3e-05 22.6 0.0 5.8e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Adaptin_binding PF10199.9 ETO03635.1 - 0.052 14.1 5.6 0.11 13.0 5.7 1.6 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 KxDL PF10241.9 ETO03635.1 - 0.48 10.7 10.2 0.19 12.0 5.5 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein ESM4 PF15952.5 ETO03635.1 - 0.62 10.5 13.1 2 8.8 13.1 1.7 1 1 0 1 1 1 0 Enhancer of split M4 family CHIP_TPR_N PF18391.1 ETO03635.1 - 2.3 9.0 10.1 1.6 9.5 7.2 2.4 2 1 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain RPN2_C PF18004.1 ETO03636.1 - 1.1 9.2 9.7 1.1 9.2 9.7 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cellulose_synt PF03552.14 ETO03636.1 - 3.9 5.8 5.0 3.9 5.8 5.0 1.0 1 0 0 1 1 1 0 Cellulose synthase TRAP_alpha PF03896.16 ETO03636.1 - 6.5 5.9 10.5 6.4 5.9 10.5 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit HEAT_2 PF13646.6 ETO03637.1 - 9.8e-17 61.1 0.0 8.3e-09 35.7 0.0 2.3 1 1 2 3 3 3 2 HEAT repeats HEAT PF02985.22 ETO03637.1 - 2.9e-14 52.0 0.0 0.00085 19.4 0.0 3.7 3 0 0 3 3 3 3 HEAT repeat HEAT_EZ PF13513.6 ETO03637.1 - 1.1e-06 29.0 0.0 0.0026 18.2 0.0 2.3 2 0 0 2 2 2 2 HEAT-like repeat Cnd1 PF12717.7 ETO03637.1 - 2.3e-06 27.8 2.2 5e-06 26.6 1.9 1.7 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO03637.1 - 4.3e-05 24.0 0.1 0.0014 19.2 0.1 2.4 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETO03637.1 - 4.9e-05 23.5 0.1 0.00034 20.8 0.0 2.3 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO03637.1 - 5.6e-05 23.4 0.0 3.3 8.6 0.0 3.5 3 0 0 3 3 3 2 PBS lyase HEAT-like repeat CLASP_N PF12348.8 ETO03637.1 - 0.00056 19.5 3.0 0.00067 19.3 0.3 2.0 2 0 0 2 2 2 1 CLASP N terminal Adaptin_N PF01602.20 ETO03637.1 - 0.0022 16.6 4.7 0.003 16.2 4.7 1.3 1 1 0 1 1 1 1 Adaptin N terminal region MOR2-PAG1_C PF14225.6 ETO03637.1 - 0.0059 16.5 0.4 0.068 13.0 0.1 2.0 1 1 0 2 2 2 1 Cell morphogenesis C-terminal NLE PF08154.12 ETO03637.1 - 0.0069 16.9 1.3 5.1 7.7 0.1 3.2 1 1 2 3 3 3 1 NLE (NUC135) domain TIP120 PF08623.10 ETO03637.1 - 0.014 15.1 0.3 1.9 8.3 0.0 2.3 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) RsfS PF02410.15 ETO03637.1 - 0.072 13.5 0.2 0.46 11.0 0.2 2.3 1 1 0 1 1 1 0 Ribosomal silencing factor during starvation TA0956 PF11513.8 ETO03637.1 - 0.088 13.0 0.1 1.1 9.5 0.0 2.2 1 1 1 2 2 2 0 Thermoplasma acidophilum protein TA0956 Spore_Cse60 PF10957.8 ETO03637.1 - 0.089 12.8 0.8 15 5.7 0.0 3.0 2 0 0 2 2 2 0 Sporulation protein Cse60 SAM_Exu PF18609.1 ETO03637.1 - 0.76 9.9 5.6 1 9.5 0.4 2.9 3 0 0 3 3 3 0 Exuperantia SAM-like domain Ion_trans PF00520.31 ETO03639.1 - 2.5e-14 53.1 12.4 2.5e-14 53.1 12.4 1.8 2 0 0 2 2 2 1 Ion transport protein AAA_23 PF13476.6 ETO03639.1 - 2.7 8.4 9.9 4 7.9 9.9 1.1 1 0 0 1 1 1 0 AAA domain CAMSAP_CKK PF08683.11 ETO03640.1 - 0.032 14.4 2.7 0.052 13.7 2.4 1.5 1 1 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated Bac_export_2 PF01312.19 ETO03640.1 - 0.041 13.1 0.4 0.041 13.1 0.4 1.7 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family DUF2681 PF10883.8 ETO03640.1 - 3.3 8.2 15.5 1.3 9.5 10.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Sugar_tr PF00083.24 ETO03640.1 - 4.1 6.1 8.2 0.044 12.6 0.7 1.5 2 0 0 2 2 2 0 Sugar (and other) transporter COesterase PF00135.28 ETO03642.1 - 0.0022 17.0 0.0 0.0022 17.0 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Prok-RING_4 PF14447.6 ETO03643.1 - 4.3e-11 42.5 7.8 7.5e-11 41.7 7.8 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETO03643.1 - 4.3e-11 42.5 6.1 4.3e-11 42.5 6.1 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO03643.1 - 5.8e-11 42.1 9.9 1.1e-10 41.2 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO03643.1 - 8.7e-11 41.5 11.2 1.5e-10 40.7 11.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO03643.1 - 1.7e-10 41.1 11.3 3.3e-10 40.1 11.3 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ETO03643.1 - 1.8e-08 34.2 9.3 4.8e-08 32.9 9.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETO03643.1 - 2.1e-07 31.0 11.2 4.9e-07 29.8 11.2 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ETO03643.1 - 1.5e-06 28.0 8.5 3e-06 27.1 8.5 1.5 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETO03643.1 - 1.7e-06 28.2 10.6 4.9e-06 26.7 10.6 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 ETO03643.1 - 7.7e-06 26.2 0.2 1.2e-05 25.6 0.2 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-ANAPC11 PF12861.7 ETO03643.1 - 0.0015 18.6 2.8 0.0035 17.3 2.8 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_6 PF14835.6 ETO03643.1 - 0.0038 17.1 4.7 0.0073 16.2 4.7 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein U-box PF04564.15 ETO03643.1 - 0.0069 16.5 0.1 0.02 15.0 0.0 1.8 2 0 0 2 2 2 1 U-box domain zf-RING_10 PF16685.5 ETO03643.1 - 0.012 15.8 6.1 0.024 14.8 6.1 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 AAA_12 PF13087.6 ETO03643.1 - 0.026 14.2 0.6 0.031 13.9 0.6 1.2 1 0 0 1 1 1 0 AAA domain YdjO PF14169.6 ETO03643.1 - 0.027 14.2 5.3 1.6 8.5 0.4 3.5 3 0 0 3 3 3 0 Cold-inducible protein YdjO zf-RING_4 PF14570.6 ETO03643.1 - 0.032 14.0 6.9 0.076 12.8 6.9 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain ERCC3_RAD25_C PF16203.5 ETO03643.1 - 0.051 12.8 1.8 0.087 12.0 0.6 1.7 1 1 1 2 2 2 0 ERCC3/RAD25/XPB C-terminal helicase Rad50_zn_hook PF04423.14 ETO03643.1 - 0.058 13.2 7.2 0.35 10.8 0.4 3.0 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RING_11 PF17123.5 ETO03643.1 - 0.086 12.6 10.6 0.095 12.5 7.3 2.4 2 0 0 2 2 2 0 RING-like zinc finger IBR PF01485.21 ETO03643.1 - 0.29 11.4 8.3 0.4 10.9 7.0 2.0 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C2H2_9 PF16293.5 ETO03643.1 - 1.3 9.0 4.7 1.4 8.8 0.0 2.7 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-C2H2_2 PF12756.7 ETO03643.1 - 4.4 7.7 8.7 0.2 12.0 2.2 2.1 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) PPR PF01535.20 ETO03644.1 - 4.1e-11 42.3 4.8 0.018 15.2 0.1 3.2 3 0 0 3 3 3 3 PPR repeat PPR_2 PF13041.6 ETO03644.1 - 9.1e-10 38.6 7.9 1.4e-05 25.2 0.2 2.9 2 1 1 3 3 3 3 PPR repeat family PPR_3 PF13812.6 ETO03644.1 - 3.5e-08 33.4 0.2 0.00021 21.3 0.0 2.8 1 1 2 3 3 3 2 Pentatricopeptide repeat domain DUF3636 PF12331.8 ETO03644.1 - 0.00033 20.5 0.2 0.00045 20.1 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3636) PPR_long PF17177.4 ETO03644.1 - 0.0014 18.0 0.7 0.059 12.7 0.3 2.0 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ETO03644.1 - 0.015 15.0 6.2 0.082 12.6 0.1 3.6 4 0 0 4 4 4 0 PPR repeat UBA_4 PF14555.6 ETO03645.1 - 5.1e-08 32.6 0.1 2.9e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 UBA-like domain TAP_C PF03943.13 ETO03645.1 - 0.061 13.0 0.0 0.14 11.8 0.0 1.6 1 0 0 1 1 1 0 TAP C-terminal domain Papo_T_antigen PF02380.15 ETO03645.1 - 0.07 13.3 3.0 0.16 12.2 3.0 1.5 1 0 0 1 1 1 0 T-antigen specific domain HTH_25 PF13413.6 ETO03645.1 - 0.13 12.2 0.1 0.31 10.9 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain SPOUT_MTase PF02590.17 ETO03645.1 - 1.2 9.1 7.4 0.086 12.8 0.9 2.4 3 0 0 3 3 3 0 Predicted SPOUT methyltransferase MAM33 PF02330.16 ETO03645.1 - 4.2 7.3 11.4 2.2 8.2 0.1 2.7 3 0 0 3 3 3 0 Mitochondrial glycoprotein HEAT PF02985.22 ETO03646.1 - 5.9e-11 41.7 0.0 0.00012 22.0 0.0 2.2 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 ETO03646.1 - 3.7e-07 30.4 0.0 7.1e-07 29.5 0.0 1.4 1 1 0 1 1 1 1 HEAT repeats HEAT_EZ PF13513.6 ETO03646.1 - 5.6e-05 23.5 0.0 0.0021 18.5 0.0 2.0 1 1 1 2 2 2 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO03646.1 - 0.00091 19.8 0.1 0.17 12.5 0.0 1.9 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETO03646.1 - 0.0052 16.8 0.1 0.013 15.5 0.1 1.6 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETO03646.1 - 0.019 14.8 0.8 0.49 10.1 0.0 2.0 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) HEAT_PBS PF03130.16 ETO03646.1 - 0.047 14.4 0.0 18 6.4 0.0 3.1 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF3052 PF11253.8 ETO03646.1 - 0.078 12.9 0.1 0.091 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) S_100 PF01023.19 ETO03646.1 - 0.084 12.6 0.2 16 5.3 0.1 2.4 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain CLASP_N PF12348.8 ETO03646.1 - 0.1 12.1 0.1 0.2 11.2 0.1 1.5 1 1 0 1 1 1 0 CLASP N terminal LMBR1 PF04791.16 ETO03647.1 - 1.7 7.4 13.1 2 7.2 13.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein GDPD PF03009.17 ETO03647.1 - 2.3 7.9 7.6 3 7.5 7.6 1.2 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family tRNA_anti-codon PF01336.25 ETO03649.1 - 5.6e-05 23.1 0.0 9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain DUF4096 PF13340.6 ETO03649.1 - 0.034 14.4 0.0 0.062 13.5 0.0 1.3 1 0 0 1 1 1 0 Putative transposase of IS4/5 family (DUF4096) WD40 PF00400.32 ETO03650.1 - 7.6e-22 77.2 18.6 1.7e-06 28.6 2.0 4.9 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03650.1 - 0.00052 20.3 0.0 1.3 9.3 0.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO03650.1 - 0.0034 17.0 2.7 0.0075 15.9 2.7 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF4221) Nup160 PF11715.8 ETO03650.1 - 0.008 14.9 0.8 0.24 10.0 0.3 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 PADR1 PF08063.12 ETO03650.1 - 0.5 10.2 4.3 5.6 6.8 0.1 2.9 3 0 0 3 3 3 0 PADR1 (NUC008) domain OSK PF17182.4 ETO03650.1 - 0.56 9.4 3.7 6.3 6.0 0.7 2.1 2 0 0 2 2 2 0 OSK domain TPR_12 PF13424.6 ETO03651.1 - 1.5e-33 114.9 0.0 5.5e-21 74.6 0.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03651.1 - 3.2e-21 74.5 0.0 4.6e-09 35.9 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03651.1 - 3.6e-18 64.5 4.5 3.8e-08 32.8 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03651.1 - 1.4e-14 52.9 0.0 2e-05 24.3 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03651.1 - 2.4e-13 49.1 1.0 6.3e-06 25.9 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03651.1 - 3.1e-11 42.6 11.3 3.3e-05 23.7 0.4 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03651.1 - 4.5e-07 29.8 0.3 0.017 15.5 0.1 2.7 2 2 0 2 2 2 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO03651.1 - 2.6e-05 24.1 0.5 0.15 11.8 0.1 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO03651.1 - 0.00041 20.0 6.5 0.56 9.9 0.0 3.9 2 2 2 4 4 4 3 TPR repeat TPR_6 PF13174.6 ETO03651.1 - 0.00049 20.6 0.1 0.91 10.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03651.1 - 0.0017 19.0 0.0 0.26 12.2 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETO03651.1 - 0.0018 18.3 3.3 0.12 12.5 0.1 2.5 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO03651.1 - 0.0039 17.4 0.6 3.1 8.3 0.1 2.3 2 0 0 2 2 2 2 PPR repeat RPN7 PF10602.9 ETO03651.1 - 0.0072 16.0 0.7 0.3 10.8 0.6 2.0 1 1 1 2 2 2 1 26S proteasome subunit RPN7 DUF357 PF04010.13 ETO03651.1 - 0.0092 16.0 0.2 2.6 8.2 0.0 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF357) TPR_16 PF13432.6 ETO03651.1 - 0.012 16.3 0.0 0.087 13.5 0.0 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat DUF5475 PF17569.2 ETO03651.1 - 0.023 15.0 0.0 2.4 8.6 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5475) FATC PF02260.20 ETO03651.1 - 0.052 13.4 0.0 9 6.2 0.0 2.1 2 0 0 2 2 2 0 FATC domain OrfA PF17495.2 ETO03651.1 - 0.06 13.5 0.0 0.46 10.7 0.0 1.9 1 1 1 2 2 2 0 Vpr-like OrfA OSTbeta PF15048.6 ETO03652.1 - 0.071 13.2 3.0 0.12 12.5 3.0 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein EssA PF10661.9 ETO03652.1 - 0.16 11.8 5.1 0.2 11.5 5.1 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA ubiquitin PF00240.23 ETO03653.1 - 0.012 15.3 0.0 0.032 14.0 0.0 1.8 1 0 0 1 1 1 0 Ubiquitin family ubiquitin PF00240.23 ETO03654.1 - 1.3e-44 149.8 8.3 1e-29 102.1 0.2 3.0 2 1 1 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ETO03654.1 - 2.1e-15 56.3 4.3 1.2e-11 44.3 0.2 3.0 2 1 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO03654.1 - 1.1e-07 32.2 1.7 3.2e-05 24.3 0.1 3.1 2 2 0 2 2 2 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO03654.1 - 0.0054 16.7 5.1 13 5.9 0.4 3.8 3 1 1 4 4 4 2 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO03654.1 - 0.0064 16.8 2.6 0.087 13.2 0.1 2.2 1 1 0 2 2 2 1 Ubiquitin-like domain PI3K_rbd PF00794.18 ETO03654.1 - 0.0099 16.0 2.7 0.64 10.2 0.5 2.5 2 1 0 2 2 2 2 PI3-kinase family, ras-binding domain NdhM PF10664.9 ETO03654.1 - 0.01 16.1 1.6 1.4 9.2 0.2 2.4 1 1 1 2 2 2 0 Cyanobacterial and plastid NDH-1 subunit M TBK1_ULD PF18396.1 ETO03654.1 - 0.011 15.6 0.2 0.029 14.3 0.1 1.7 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain FERM_f0 PF16511.5 ETO03654.1 - 0.017 15.4 1.0 4.1 7.8 0.1 2.6 2 1 0 2 2 2 0 N-terminal or F0 domain of Talin-head FERM Lipase_3 PF01764.25 ETO03657.1 - 3.4e-13 49.7 0.0 6.3e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) SDA1 PF05285.12 ETO03658.1 - 0.018 14.5 8.9 0.024 14.1 8.9 1.1 1 0 0 1 1 1 0 SDA1 DUF2569 PF10754.9 ETO03658.1 - 1.2 9.5 5.4 0.45 10.9 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2569) Nha1_C PF08619.10 ETO03660.1 - 5.4e-05 22.6 8.8 5.8e-05 22.5 8.8 1.1 1 0 0 1 1 1 1 Alkali metal cation/H+ antiporter Nha1 C terminus FAM76 PF16046.5 ETO03660.1 - 0.81 9.0 5.1 0.96 8.7 5.1 1.2 1 0 0 1 1 1 0 FAM76 protein Apt1 PF10351.9 ETO03660.1 - 2.4 6.9 17.6 3 6.6 17.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain 2OG-FeII_Oxy_3 PF13640.6 ETO03661.1 - 3.1e-06 28.0 0.1 0.0011 19.8 0.0 2.7 2 0 0 2 2 2 2 2OG-Fe(II) oxygenase superfamily DUF4834 PF16118.5 ETO03661.1 - 5 8.2 8.7 30 5.7 2.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO03662.1 - 1.1e-31 108.4 16.8 2.2e-07 31.5 0.8 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO03662.1 - 2.2e-10 40.7 0.5 0.00079 19.7 0.0 4.8 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO03662.1 - 9e-05 21.3 2.5 0.13 10.8 0.1 3.7 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF4265 PF14085.6 ETO03662.1 - 0.047 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4265) CENP-B_dimeris PF09026.10 ETO03663.1 - 1.7 9.1 14.0 2.2 8.7 14.0 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ETO03663.1 - 5.8 5.9 11.3 6.1 5.9 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO03663.1 - 7 4.6 7.8 7.2 4.6 7.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi SelK_SelG PF10961.8 ETO03664.1 - 0.064 13.9 1.4 0.13 12.9 1.4 1.6 1 0 0 1 1 1 0 Selenoprotein SelK_SelG RecO_C PF02565.15 ETO03664.1 - 0.21 11.4 0.1 0.41 10.4 0.1 1.3 1 0 0 1 1 1 0 Recombination protein O C terminal DUF2457 PF10446.9 ETO03667.1 - 0.29 10.2 23.5 0.32 10.1 23.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Paf1 PF03985.13 ETO03667.1 - 0.57 9.1 21.1 0.64 9.0 21.1 1.0 1 0 0 1 1 1 0 Paf1 PTPRCAP PF15713.5 ETO03667.1 - 5.5 7.3 20.6 6.7 7.0 20.6 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated NACHT PF05729.12 ETO03668.1 - 7e-18 65.1 0.0 1.2e-15 57.8 0.0 3.1 2 1 0 2 2 2 1 NACHT domain HEAT_2 PF13646.6 ETO03668.1 - 1.5e-07 31.7 0.0 0.041 14.3 0.0 4.7 3 2 1 4 4 4 2 HEAT repeats Ank_3 PF13606.6 ETO03668.1 - 1.8e-07 30.9 0.1 0.0012 19.1 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 ETO03668.1 - 1.7e-06 28.6 4.8 3.9e-06 27.4 0.0 3.9 4 1 0 4 4 3 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO03668.1 - 2.3e-06 27.7 0.1 0.00016 21.9 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) HEAT PF02985.22 ETO03668.1 - 1.8e-05 24.6 0.1 0.92 9.9 0.0 4.5 3 0 0 3 3 3 2 HEAT repeat Ank_4 PF13637.6 ETO03668.1 - 9.6e-05 22.9 1.2 0.0003 21.3 0.2 2.6 2 0 0 2 2 1 1 Ankyrin repeats (many copies) HEAT_EZ PF13513.6 ETO03668.1 - 0.00067 20.1 0.0 5 7.7 0.0 3.5 2 1 0 3 3 3 2 HEAT-like repeat Ank PF00023.30 ETO03668.1 - 0.00089 19.6 0.0 0.076 13.5 0.0 3.3 2 0 0 2 2 2 1 Ankyrin repeat AAA_16 PF13191.6 ETO03668.1 - 0.0032 17.9 0.0 0.08 13.3 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ETO03668.1 - 0.0041 16.4 0.1 0.076 12.2 0.0 2.6 2 0 0 2 2 2 1 NB-ARC domain Symplekin_C PF12295.8 ETO03668.1 - 0.016 15.3 2.2 18 5.4 0.0 4.8 3 1 2 5 5 5 0 Symplekin tight junction protein C terminal TIP120 PF08623.10 ETO03668.1 - 0.018 14.8 2.4 0.07 12.9 0.1 2.9 2 1 1 3 3 3 0 TATA-binding protein interacting (TIP20) Vac14_Fab1_bd PF12755.7 ETO03668.1 - 0.059 14.0 6.4 8.1 7.1 0.1 4.5 4 1 1 5 5 4 0 Vacuolar 14 Fab1-binding region Lambda_CIII PF02061.16 ETO03668.1 - 0.068 13.2 0.1 0.37 10.9 0.1 2.2 2 0 0 2 2 1 0 Lambda Phage CIII Gcn1_N PF12074.8 ETO03668.1 - 0.099 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal NLRC4_HD2 PF17776.1 ETO03668.1 - 0.22 12.1 5.7 0.25 11.9 0.0 4.2 5 1 1 6 6 4 0 NLRC4 helical domain HD2 Cys_rich_KTR PF14205.6 ETO03670.1 - 0.04 13.7 0.0 0.15 11.9 0.0 2.0 1 0 0 1 1 1 0 Cysteine-rich KTR AbiEi_3 PF11459.8 ETO03671.1 - 0.028 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system Spc42p PF11544.8 ETO03672.1 - 1.6 8.8 9.9 0.056 13.4 1.9 2.8 2 1 1 3 3 3 0 Spindle pole body component Spc42p Neur_chan_memb PF02932.16 ETO03672.1 - 8.7 6.3 9.0 10 6.1 9.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO03673.1 - 0.37 10.0 1.4 0.42 9.8 1.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 ETO03673.1 - 1.2 8.5 11.7 1.8 7.9 11.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 ETO03673.1 - 2.5 6.8 4.5 3 6.5 4.5 1.1 1 0 0 1 1 1 0 Presenilin Cytomega_UL84 PF06284.11 ETO03673.1 - 5.5 5.3 5.6 7.4 4.9 5.6 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein O-antigen_lig PF13425.6 ETO03673.1 - 6.7 5.4 6.0 9.1 4.9 6.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PPR PF01535.20 ETO03677.1 - 3.8e-16 58.1 3.3 0.0054 16.9 0.0 5.7 6 0 0 6 6 6 4 PPR repeat PPR_3 PF13812.6 ETO03677.1 - 8e-14 51.5 6.0 3.7e-07 30.1 0.0 4.7 3 1 2 5 5 5 4 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO03677.1 - 3.1e-13 49.7 12.8 1.2e-07 31.8 0.1 4.9 4 1 2 6 6 6 3 PPR repeat family PPR_1 PF12854.7 ETO03677.1 - 1.1e-12 47.4 2.6 0.0018 18.0 0.0 4.4 4 0 0 4 4 4 3 PPR repeat PPR_long PF17177.4 ETO03677.1 - 1.8e-07 30.8 0.0 3e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO03677.1 - 0.051 13.4 0.5 0.051 13.4 0.5 2.8 3 0 0 3 3 3 0 Mitochondrial ATPase expression DUF3636 PF12331.8 ETO03677.1 - 0.11 12.3 0.1 0.18 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) WD40 PF00400.32 ETO03680.1 - 3.6e-17 62.4 15.7 1.6e-06 28.7 0.3 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO03680.1 - 1.5e-05 23.8 0.3 0.2 10.2 0.3 2.8 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO03680.1 - 3.2e-05 24.1 0.1 0.18 12.1 0.0 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Pox_TAP PF03355.14 ETO03680.1 - 0.031 13.9 1.3 0.041 13.5 1.3 1.1 1 0 0 1 1 1 0 Viral Trans-Activator Protein PSI PF01437.25 ETO03680.1 - 0.22 12.1 5.2 0.22 12.1 3.4 2.1 1 1 1 2 2 2 0 Plexin repeat Kelch_6 PF13964.6 ETO03680.1 - 0.47 10.8 3.0 5.4 7.5 0.1 2.9 3 0 0 3 3 3 0 Kelch motif HEAT_2 PF13646.6 ETO03681.1 - 0.0002 21.7 0.0 0.00061 20.1 0.1 1.7 1 1 0 1 1 1 1 HEAT repeats Cnd1 PF12717.7 ETO03681.1 - 0.00042 20.4 0.0 0.00055 20.0 0.0 1.2 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO03681.1 - 0.033 14.8 0.1 6.1 7.5 0.0 2.3 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ETO03681.1 - 0.11 12.8 0.7 51 4.5 0.1 3.3 3 0 0 3 3 3 0 HEAT repeat PDDEXK_5 PF11645.8 ETO03683.1 - 2.7e-06 27.4 2.0 7.6e-06 25.9 0.2 2.1 1 1 1 2 2 2 1 PD-(D/E)XK endonuclease MepB PF08877.10 ETO03683.1 - 0.023 14.4 0.4 0.037 13.7 0.3 1.6 1 1 0 1 1 1 0 MepB protein RNA_pol_Rpc4 PF05132.14 ETO03687.1 - 0.35 11.3 10.0 0.034 14.6 5.5 1.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 TLD PF07534.16 ETO03688.1 - 1e-05 25.8 0.0 2.4e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 TLD RRM_1 PF00076.22 ETO03689.1 - 9.1e-12 44.6 0.7 9.2e-10 38.2 0.2 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2100 PF09873.9 ETO03690.1 - 0.037 13.9 0.1 0.046 13.6 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2100) MADF_DNA_bdg PF10545.9 ETO03690.1 - 0.05 13.9 1.1 0.24 11.7 0.6 1.9 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like Pkinase PF00069.25 ETO03691.1 - 1.6e-18 67.0 0.0 1.8e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03691.1 - 0.00061 19.1 0.0 0.00069 19.0 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO03692.1 - 1.6e-20 73.6 0.2 1.9e-20 73.3 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03692.1 - 4.1e-11 42.7 0.2 4.9e-11 42.4 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Coilin_N PF15862.5 ETO03693.1 - 0.015 15.1 18.1 0.035 13.9 18.1 1.6 1 1 0 1 1 1 0 Coilin N-terminus Nop53 PF07767.11 ETO03693.1 - 0.14 11.5 30.3 0.18 11.1 30.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RNA_polI_A34 PF08208.11 ETO03693.1 - 0.53 10.3 28.2 0.73 9.9 28.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Striatin PF08232.12 ETO03693.1 - 0.8 10.3 22.9 0.87 10.2 22.5 1.3 1 1 0 1 1 1 0 Striatin family Secretin_N_2 PF07655.13 ETO03693.1 - 0.97 10.0 10.8 1.7 9.3 10.8 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain CDC45 PF02724.14 ETO03693.1 - 1.3 7.3 21.0 1.5 7.0 21.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO03693.1 - 1.8 8.3 21.7 2 8.2 21.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SR-25 PF10500.9 ETO03693.1 - 1.9 8.0 27.0 2.4 7.7 27.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AAA_11 PF13086.6 ETO03693.1 - 2.2 8.0 19.8 2.4 7.9 19.8 1.1 1 0 0 1 1 1 0 AAA domain Vfa1 PF08432.10 ETO03693.1 - 3 8.2 26.7 4 7.7 26.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Macoilin PF09726.9 ETO03693.1 - 3.5 6.1 22.1 4.2 5.8 22.1 1.0 1 0 0 1 1 1 0 Macoilin family Cupin_8 PF13621.6 ETO03693.1 - 5 6.8 12.9 7.4 6.2 12.9 1.3 1 1 0 1 1 1 0 Cupin-like domain Zip PF02535.22 ETO03693.1 - 6.3 5.9 11.9 7.3 5.7 11.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MIT PF04212.18 ETO03694.1 - 0.0001 22.3 1.4 0.00017 21.6 1.4 1.3 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain ADPrib_exo_Tox PF03496.14 ETO03694.1 - 0.044 13.1 0.1 0.054 12.8 0.1 1.2 1 0 0 1 1 1 0 ADP-ribosyltransferase exoenzyme V-SNARE PF05008.15 ETO03694.1 - 0.17 12.2 1.6 0.54 10.7 1.6 1.9 1 1 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus TPR_8 PF13181.6 ETO03694.1 - 0.21 11.9 0.5 0.49 10.7 0.5 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Baculo_19 PF04798.12 ETO03695.1 - 0.079 12.7 0.0 0.11 12.2 0.0 1.2 1 0 0 1 1 1 0 Baculovirus 19 kDa protein conserved region FYTT PF07078.11 ETO03696.1 - 0.042 13.2 0.0 0.07 12.4 0.0 1.3 1 0 0 1 1 1 0 Forty-two-three protein Cas_Csx9 PF09658.10 ETO03696.1 - 0.22 10.7 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csx9) CBS PF00571.28 ETO03697.1 - 9.1e-06 26.0 0.0 1.4e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 CBS domain OTCace PF00185.24 ETO03697.1 - 0.00057 20.0 0.0 0.00077 19.6 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain KH_8 PF17903.1 ETO03698.1 - 0.029 14.5 2.6 1.5 8.9 0.0 2.2 2 0 0 2 2 2 0 Krr1 KH1 domain Amidase PF01425.21 ETO03698.1 - 0.054 12.4 0.5 0.065 12.2 0.5 1.0 1 0 0 1 1 1 0 Amidase Borrelia_P83 PF05262.11 ETO03698.1 - 0.055 11.9 2.7 0.089 11.3 2.7 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein PGA2 PF07543.12 ETO03698.1 - 7 6.6 13.5 22 5.0 11.3 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 DUF2407_C PF13373.6 ETO03698.1 - 9.3 6.4 9.9 5.9 7.1 5.0 2.0 2 0 0 2 2 2 0 DUF2407 C-terminal domain TSC22 PF01166.18 ETO03699.1 - 0.00025 21.3 11.6 0.00086 19.6 0.5 3.2 3 0 0 3 3 3 2 TSC-22/dip/bun family GIT_CC PF16559.5 ETO03699.1 - 0.53 10.2 15.9 1.2 9.0 0.5 3.3 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor SOGA PF11365.8 ETO03699.1 - 0.73 11.0 12.5 1.7 9.8 6.4 2.1 1 1 1 2 2 2 0 Protein SOGA AAA_13 PF13166.6 ETO03699.1 - 0.75 8.4 11.6 0.24 10.0 5.3 2.0 1 1 1 2 2 2 0 AAA domain DUF16 PF01519.16 ETO03699.1 - 2.3 8.8 9.8 0.87 10.1 2.4 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF724 PF05266.14 ETO03699.1 - 4.3 7.1 15.6 4.2 7.2 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DivIC PF04977.15 ETO03699.1 - 6.9 6.5 14.1 8.1 6.3 1.1 3.2 3 0 0 3 3 3 0 Septum formation initiator LIN37 PF15306.6 ETO03700.1 - 0.032 14.5 0.1 0.043 14.0 0.1 1.1 1 0 0 1 1 1 0 LIN37 PDZ PF00595.24 ETO03701.1 - 0.0055 17.0 0.2 0.013 15.8 0.2 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO03701.1 - 0.045 13.6 0.1 1 9.2 0.1 2.4 2 0 0 2 2 2 0 PDZ domain Arf PF00025.21 ETO03702.1 - 3.3e-67 225.3 0.2 1.1e-66 223.6 0.2 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO03702.1 - 1.3e-12 48.0 0.0 1.9e-12 47.5 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETO03702.1 - 4.2e-11 42.6 0.0 6.8e-11 41.9 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ETO03702.1 - 1.7e-10 40.6 0.4 1.5e-07 30.9 0.0 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ETO03702.1 - 2.3e-09 37.1 0.0 2.9e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ETO03702.1 - 4.5e-05 22.9 0.0 6.4e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region NACHT PF05729.12 ETO03702.1 - 0.001 19.0 0.2 0.0018 18.2 0.2 1.5 1 1 0 1 1 1 1 NACHT domain MMR_HSR1 PF01926.23 ETO03702.1 - 0.0053 16.8 0.0 0.01 15.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RNaseH_pPIWI_RE PF13032.6 ETO03702.1 - 0.029 14.3 0.0 0.035 14.0 0.0 1.1 1 0 0 1 1 1 0 RNaseH domain of pPIWI_RE SpoIIIAH PF12685.7 ETO03703.1 - 0.16 11.7 4.5 0.22 11.4 3.7 1.5 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF1664 PF07889.12 ETO03705.1 - 2e-05 24.6 6.9 2.9e-05 24.1 6.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) UPF0242 PF06785.11 ETO03705.1 - 0.00019 21.6 18.1 0.00027 21.1 18.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus HMMR_N PF15905.5 ETO03705.1 - 0.00053 19.6 16.9 0.00067 19.2 16.9 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Lzipper-MIP1 PF14389.6 ETO03705.1 - 0.0012 19.1 12.9 0.15 12.4 0.4 2.1 1 1 1 2 2 2 2 Leucine-zipper of ternary complex factor MIP1 HAP1_N PF04849.13 ETO03705.1 - 0.0015 17.8 13.2 0.0019 17.4 13.2 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region DUF812 PF05667.11 ETO03705.1 - 0.0016 17.5 14.9 0.0019 17.1 14.9 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) FliD_C PF07195.12 ETO03705.1 - 0.0018 17.8 4.3 0.0018 17.8 4.3 2.0 1 1 0 2 2 2 1 Flagellar hook-associated protein 2 C-terminus Spc7 PF08317.11 ETO03705.1 - 0.0021 17.0 16.1 0.0025 16.7 16.1 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein FlxA PF14282.6 ETO03705.1 - 0.0022 18.0 18.8 0.0035 17.3 18.8 1.3 1 0 0 1 1 1 1 FlxA-like protein Jnk-SapK_ap_N PF09744.9 ETO03705.1 - 0.0036 17.5 16.9 0.006 16.8 16.9 1.3 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 HOOK PF05622.12 ETO03705.1 - 0.0042 15.3 14.0 0.0064 14.7 14.0 1.3 1 0 0 1 1 1 1 HOOK protein Cnn_1N PF07989.11 ETO03705.1 - 0.0051 16.9 11.7 0.0051 16.9 11.7 2.2 1 1 1 2 2 2 1 Centrosomin N-terminal motif 1 bZIP_1 PF00170.21 ETO03705.1 - 0.0055 16.8 7.1 0.0055 16.8 7.1 2.4 1 1 1 2 2 2 1 bZIP transcription factor TSC22 PF01166.18 ETO03705.1 - 0.0058 16.9 3.7 0.0058 16.9 3.7 2.4 1 1 1 2 2 2 1 TSC-22/dip/bun family ADIP PF11559.8 ETO03705.1 - 0.006 16.7 19.9 0.17 12.0 8.0 2.0 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding Vps5 PF09325.10 ETO03705.1 - 0.0073 15.9 10.0 0.03 13.9 6.1 1.9 1 1 1 2 2 2 1 Vps5 C terminal like DUF4407 PF14362.6 ETO03705.1 - 0.0079 15.6 7.9 0.01 15.2 7.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) GAS PF13851.6 ETO03705.1 - 0.011 15.1 17.0 0.014 14.7 17.0 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FapA PF03961.13 ETO03705.1 - 0.011 14.3 10.5 0.013 14.1 10.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A FlaC_arch PF05377.11 ETO03705.1 - 0.012 16.0 14.6 0.09 13.2 3.0 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.8 ETO03705.1 - 0.013 15.4 21.6 0.021 14.8 7.6 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 ETO03705.1 - 0.015 15.5 15.0 0.037 14.2 14.9 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Geminin PF07412.12 ETO03705.1 - 0.016 14.9 14.0 0.019 14.7 4.1 2.1 1 1 1 2 2 2 0 Geminin DivIC PF04977.15 ETO03705.1 - 0.018 14.8 4.4 0.018 14.8 4.4 2.8 1 1 2 3 3 3 0 Septum formation initiator Golgin_A5 PF09787.9 ETO03705.1 - 0.018 14.5 14.6 0.023 14.2 14.6 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 Tropomyosin_1 PF12718.7 ETO03705.1 - 0.019 15.1 16.7 0.026 14.7 16.7 1.1 1 0 0 1 1 1 0 Tropomyosin like DUF4515 PF14988.6 ETO03705.1 - 0.029 14.2 21.5 0.064 13.1 21.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4515) SKA2 PF16740.5 ETO03705.1 - 0.03 14.1 14.3 0.11 12.3 14.4 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Herpes_BLRF2 PF05812.12 ETO03705.1 - 0.038 14.1 8.4 0.049 13.8 8.0 1.5 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein TPR_MLP1_2 PF07926.12 ETO03705.1 - 0.053 13.6 20.1 0.13 12.3 20.1 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein K-box PF01486.17 ETO03705.1 - 0.053 13.7 14.3 0.08 13.1 14.3 1.2 1 0 0 1 1 1 0 K-box region DUF5082 PF16888.5 ETO03705.1 - 0.054 13.8 12.9 0.13 12.6 4.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DUF2935 PF11155.8 ETO03705.1 - 0.057 13.7 6.6 0.07 13.5 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) DUF1319 PF07028.11 ETO03705.1 - 0.059 13.6 7.7 0.094 12.9 7.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) Adhesin_P1_N PF18652.1 ETO03705.1 - 0.064 13.3 1.4 0.064 13.3 1.4 2.4 1 1 1 2 2 2 0 Adhesin P1 N-terminal domain ABC_tran_CTD PF16326.5 ETO03705.1 - 0.076 13.3 17.5 0.073 13.3 10.2 2.1 1 1 2 3 3 3 0 ABC transporter C-terminal domain Sec2p PF06428.11 ETO03705.1 - 0.098 12.6 21.0 0.18 11.8 4.9 2.1 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p Paralemmin PF03285.15 ETO03705.1 - 0.1 12.2 9.0 0.12 11.9 9.0 1.1 1 0 0 1 1 1 0 Paralemmin Leu_zip PF15294.6 ETO03705.1 - 0.12 11.9 16.9 0.24 10.9 16.7 1.6 1 1 1 2 2 2 0 Leucine zipper Spc24 PF08286.11 ETO03705.1 - 0.12 12.6 18.5 0.27 11.5 7.6 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Atg14 PF10186.9 ETO03705.1 - 0.13 11.3 12.3 0.15 11.1 12.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Lectin_N PF03954.14 ETO03705.1 - 0.13 12.0 10.3 0.12 12.1 6.9 2.0 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Phage_GPO PF05929.11 ETO03705.1 - 0.14 11.8 7.9 0.17 11.5 7.9 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Lebercilin PF15619.6 ETO03705.1 - 0.15 11.7 19.6 0.32 10.6 19.6 1.5 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease ZapB PF06005.12 ETO03705.1 - 0.17 12.3 24.7 0.08 13.4 9.3 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Fzo_mitofusin PF04799.13 ETO03705.1 - 0.19 11.2 12.5 0.076 12.6 1.4 2.0 1 1 1 2 2 2 0 fzo-like conserved region TMCO5 PF14992.6 ETO03705.1 - 0.2 11.2 15.2 0.23 11.0 15.2 1.1 1 0 0 1 1 1 0 TMCO5 family V_ATPase_I PF01496.19 ETO03705.1 - 0.21 9.5 8.9 0.24 9.3 8.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WXG100 PF06013.12 ETO03705.1 - 0.21 11.9 6.4 1.4 9.2 6.3 2.1 1 1 0 1 1 1 0 Proteins of 100 residues with WXG Exonuc_VII_L PF02601.15 ETO03705.1 - 0.21 11.1 8.7 0.24 10.9 8.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DHR10 PF18595.1 ETO03705.1 - 0.22 11.6 21.5 1.1 9.3 9.7 2.0 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Laminin_II PF06009.12 ETO03705.1 - 0.24 11.4 11.0 0.31 11.0 11.0 1.1 1 0 0 1 1 1 0 Laminin Domain II TMPIT PF07851.13 ETO03705.1 - 0.25 10.5 9.8 0.32 10.2 9.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein Tho2 PF11262.8 ETO03705.1 - 0.26 10.5 9.2 0.32 10.1 9.2 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF5595 PF18077.1 ETO03705.1 - 0.26 11.4 12.7 0.7 10.0 3.2 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5595) DUF489 PF04356.12 ETO03705.1 - 0.3 11.1 7.6 0.43 10.6 7.1 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF489) FUSC PF04632.12 ETO03705.1 - 0.3 9.5 0.3 0.34 9.4 0.3 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family Swi5 PF07061.11 ETO03705.1 - 0.31 11.2 17.1 0.88 9.7 4.3 2.2 1 1 1 2 2 2 0 Swi5 DUF4250 PF14056.6 ETO03705.1 - 0.41 10.6 5.9 0.14 12.1 2.0 2.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4250) DUF948 PF06103.11 ETO03705.1 - 0.49 10.7 6.2 1.8 8.9 6.2 1.8 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Shugoshin_N PF07558.11 ETO03705.1 - 0.53 10.2 12.1 0.16 11.8 6.3 2.4 2 1 0 2 2 2 0 Shugoshin N-terminal coiled-coil region DUF4200 PF13863.6 ETO03705.1 - 0.56 10.6 20.9 1.2 9.6 5.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) APG6_N PF17675.1 ETO03705.1 - 0.6 10.6 22.5 0.58 10.7 9.5 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region SlyX PF04102.12 ETO03705.1 - 0.65 10.7 17.2 0.39 11.4 1.7 2.1 1 1 1 2 2 2 0 SlyX Prefoldin PF02996.17 ETO03705.1 - 0.74 9.7 15.3 1.2 9.1 4.2 2.2 1 1 1 2 2 2 0 Prefoldin subunit BLOC1_2 PF10046.9 ETO03705.1 - 0.9 9.9 16.3 0.18 12.2 5.6 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.8 ETO03705.1 - 0.94 8.7 16.6 1.5 8.1 16.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 ETO03705.1 - 0.98 9.7 17.3 5.3 7.3 17.3 1.8 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CLZ PF16526.5 ETO03705.1 - 1 9.7 13.8 0.097 13.0 5.0 2.3 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4446 PF14584.6 ETO03705.1 - 1.2 9.1 12.6 2.1 8.3 3.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) GIT_CC PF16559.5 ETO03705.1 - 1.3 9.0 16.9 0.13 12.1 3.8 2.6 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF3847 PF12958.7 ETO03705.1 - 1.3 9.2 14.3 2.7 8.2 6.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3847) YabA PF06156.13 ETO03705.1 - 1.3 9.7 15.2 41 4.9 15.2 2.1 1 1 0 1 1 1 0 Initiation control protein YabA FbpA PF05833.11 ETO03705.1 - 1.4 7.5 15.9 0.27 10.0 10.6 1.8 1 1 1 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) DASH_Dam1 PF08653.10 ETO03705.1 - 1.7 8.5 4.2 17 5.3 0.3 2.5 1 1 1 2 2 2 0 DASH complex subunit Dam1 Ax_dynein_light PF10211.9 ETO03705.1 - 1.8 8.5 18.2 9.7 6.1 18.2 1.9 1 1 0 1 1 1 0 Axonemal dynein light chain Prominin PF05478.11 ETO03705.1 - 1.8 6.4 11.4 9.8 4.0 11.6 1.5 1 1 0 1 1 1 0 Prominin Csm1_N PF18504.1 ETO03705.1 - 2 8.8 21.0 2.4 8.5 6.3 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain ATG16 PF08614.11 ETO03705.1 - 2 8.6 19.7 4.4 7.5 19.7 1.5 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CENP-H PF05837.12 ETO03705.1 - 2.1 8.8 15.9 9.9 6.6 15.9 1.8 1 1 0 1 1 1 0 Centromere protein H (CENP-H) PspA_IM30 PF04012.12 ETO03705.1 - 2.2 7.8 18.3 23 4.5 18.4 1.8 1 1 0 1 1 1 0 PspA/IM30 family DUF3552 PF12072.8 ETO03705.1 - 2.3 7.6 20.6 27 4.1 20.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) OmpH PF03938.14 ETO03705.1 - 2.5 8.5 20.1 6.1 7.2 20.1 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) NPV_P10 PF05531.12 ETO03705.1 - 2.5 8.6 9.4 24 5.5 9.4 2.1 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein GrpE PF01025.19 ETO03705.1 - 2.5 7.7 16.1 9.7 5.8 16.1 1.7 1 1 0 1 1 1 0 GrpE DUF3573 PF12097.8 ETO03705.1 - 2.8 6.7 5.8 3.4 6.4 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF4140 PF13600.6 ETO03705.1 - 3.1 8.3 12.1 2.7 8.5 1.7 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Sec62 PF03839.16 ETO03705.1 - 3.2 7.2 9.0 3.6 7.0 9.0 1.0 1 0 0 1 1 1 0 Translocation protein Sec62 UPF0449 PF15136.6 ETO03705.1 - 3.5 8.2 16.8 0.35 11.3 2.8 2.1 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 eIF-4B PF06273.11 ETO03705.1 - 3.8 6.5 8.5 4.8 6.1 8.5 1.2 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B bZIP_Maf PF03131.17 ETO03705.1 - 4.8 7.8 16.2 2.7e+02 2.2 16.2 2.4 1 1 0 1 1 1 0 bZIP Maf transcription factor DivIVA PF05103.13 ETO03705.1 - 4.9 7.2 18.0 2.1 8.4 3.3 2.5 1 1 2 3 3 3 0 DivIVA protein DUF4337 PF14235.6 ETO03705.1 - 5 7.2 10.8 0.34 11.0 3.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF2203 PF09969.9 ETO03705.1 - 5.2 7.8 9.5 4.2 8.1 6.4 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) LMBR1 PF04791.16 ETO03705.1 - 6.1 5.6 7.2 7.6 5.3 7.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein dCache_2 PF08269.11 ETO03705.1 - 7.8 5.6 12.4 10 5.2 12.4 1.2 1 0 0 1 1 1 0 Cache domain MerR-DNA-bind PF09278.11 ETO03705.1 - 8.5 7.0 9.6 21 5.8 0.3 2.5 1 1 1 2 2 2 0 MerR, DNA binding B56 PF01603.20 ETO03706.1 - 2.3e-36 125.7 0.5 2.5e-36 125.6 0.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) ENTH PF01417.20 ETO03706.1 - 0.074 13.1 0.0 0.23 11.5 0.0 1.7 1 1 1 2 2 2 0 ENTH domain Aldedh PF00171.22 ETO03708.1 - 1.1e-25 90.1 0.0 1.2e-25 90.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Homeobox_KN PF05920.11 ETO03709.1 - 3e-14 52.6 0.3 4.9e-14 52.0 0.3 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ETO03709.1 - 5.4e-09 35.8 0.7 9.5e-09 35.0 0.7 1.4 1 0 0 1 1 1 1 Homeodomain TFIIA_gamma_N PF02268.16 ETO03710.1 - 0.057 13.4 0.1 4 7.5 0.0 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIA, gamma subunit, helical domain RhoGEF PF00621.20 ETO03710.1 - 0.057 13.7 0.9 0.48 10.7 0.9 2.0 1 1 0 1 1 1 0 RhoGEF domain DCB PF16213.5 ETO03711.1 - 9.1e-09 35.2 0.4 1.1e-08 35.0 0.4 1.0 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 ATP13 PF12921.7 ETO03712.1 - 0.0056 16.5 0.0 0.0076 16.1 0.0 1.2 1 0 0 1 1 1 1 Mitochondrial ATPase expression ssDNA-exonuc_C PF10141.9 ETO03712.1 - 0.0056 16.3 0.0 0.0058 16.3 0.0 1.2 1 0 0 1 1 1 1 Single-strand DNA-specific exonuclease, C terminal domain ParB PF08775.10 ETO03713.1 - 0.07 13.6 1.3 0.26 11.8 0.1 2.0 1 1 1 2 2 2 0 ParB family Tsi6 PF18660.1 ETO03713.1 - 0.09 12.8 1.1 1.1 9.3 0.4 2.6 3 0 0 3 3 3 0 Tsi6 Glu-tRNAGln PF02686.15 ETO03713.1 - 0.12 12.6 0.0 0.45 10.8 0.0 1.8 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit DUF572 PF04502.13 ETO03714.1 - 7.1e-48 163.9 19.2 8.9e-48 163.6 19.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF572) DZR PF12773.7 ETO03714.1 - 0.025 14.6 4.5 1.1 9.4 0.7 3.1 2 1 1 3 3 3 0 Double zinc ribbon YwqJ-deaminase PF14431.6 ETO03714.1 - 0.11 12.7 2.2 0.18 12.0 2.2 1.4 1 0 0 1 1 1 0 YwqJ-like deaminase zf-ribbon_3 PF13248.6 ETO03714.1 - 0.76 9.3 7.4 18 4.9 0.3 3.2 3 0 0 3 3 3 0 zinc-ribbon domain RNA_pol_N PF01194.17 ETO03714.1 - 9.5 6.6 12.5 1.6 9.1 0.4 3.7 4 1 0 4 4 4 0 RNA polymerases N / 8 kDa subunit PH_2 PF08458.10 ETO03716.1 - 0.0009 19.6 0.0 0.0014 19.0 0.0 1.3 1 0 0 1 1 1 1 Plant pleckstrin homology-like region PH PF00169.29 ETO03716.1 - 0.0079 16.7 0.2 0.062 13.8 0.2 2.0 1 1 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 ETO03716.1 - 0.11 12.6 0.0 0.28 11.3 0.0 1.8 1 1 1 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology PH_11 PF15413.6 ETO03716.1 - 0.17 12.3 0.3 0.36 11.3 0.3 1.6 1 1 0 1 1 1 0 Pleckstrin homology domain Ank_2 PF12796.7 ETO03717.1 - 0.009 16.6 0.1 0.029 15.0 0.1 1.9 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) MBR1 PF17058.5 ETO03717.1 - 0.15 12.3 2.3 2.9 8.1 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial biogenesis regulation protein 1 zf-primase PF09329.11 ETO03719.1 - 2.5e-06 27.2 0.5 6.5e-06 25.8 0.5 1.7 1 0 0 1 1 1 1 Primase zinc finger DUF244 PF03112.14 ETO03719.1 - 0.024 14.5 1.0 0.058 13.2 1.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein family (ORF7) DUF PRC2_HTH_1 PF18118.1 ETO03719.1 - 0.098 13.5 5.4 0.19 12.6 5.4 1.5 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Pkinase PF00069.25 ETO03720.1 - 2.3e-41 141.9 0.0 2.6e-41 141.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03720.1 - 5.8e-21 74.9 0.0 6.3e-21 74.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO03720.1 - 0.00016 21.1 0.0 0.00021 20.7 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO03720.1 - 0.0023 16.8 0.0 0.0029 16.5 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Pkinase PF00069.25 ETO03721.1 - 2.4e-22 79.6 0.1 2.7e-22 79.4 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03721.1 - 1.6e-11 44.0 0.1 1.9e-11 43.8 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4887 PF16228.5 ETO03722.1 - 1.7 8.8 21.0 0.027 14.7 10.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4887) DUF4589 PF15252.6 ETO03722.1 - 2.8 7.9 13.5 0.32 11.0 8.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4589) ABC2_membrane_3 PF12698.7 ETO03723.1 - 4.1e-28 98.5 19.6 4.7e-28 98.3 19.6 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein NrsF PF06532.11 ETO03723.1 - 0.041 13.6 1.9 0.075 12.7 1.9 1.4 1 0 0 1 1 1 0 Negative regulator of sigma F ABC2_membrane_2 PF12679.7 ETO03723.1 - 0.24 10.7 15.7 0.43 9.8 15.7 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein V-SNARE_C PF12352.8 ETO03725.1 - 2.4e-09 37.4 2.3 3.5e-09 36.8 2.3 1.3 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO03725.1 - 5.2e-07 29.5 0.4 7.1e-07 29.1 0.4 1.2 1 0 0 1 1 1 1 Sec20 SNARE PF05739.19 ETO03725.1 - 0.0061 16.5 1.3 0.0061 16.5 1.3 2.0 3 0 0 3 3 2 1 SNARE domain EMP24_GP25L PF01105.24 ETO03725.1 - 0.0068 16.4 0.6 0.0089 16.0 0.6 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Mobilization_B PF17511.2 ETO03725.1 - 0.013 15.8 0.0 0.016 15.6 0.0 1.1 1 0 0 1 1 1 0 Mobilization protein B DUF2207 PF09972.9 ETO03725.1 - 0.015 14.1 2.6 0.017 13.9 2.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Tetraspanin PF00335.20 ETO03725.1 - 0.02 14.6 0.2 0.037 13.7 0.2 1.4 1 0 0 1 1 1 0 Tetraspanin family Ferlin_C PF16165.5 ETO03725.1 - 0.021 14.8 7.2 0.032 14.2 7.2 1.3 1 1 0 1 1 1 0 Ferlin C-terminus Prominin PF05478.11 ETO03725.1 - 0.033 12.1 0.6 0.037 12.0 0.6 1.0 1 0 0 1 1 1 0 Prominin DUF4407 PF14362.6 ETO03725.1 - 0.037 13.4 2.2 0.046 13.1 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 ETO03725.1 - 0.11 12.9 1.6 0.2 12.2 1.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Amnionless PF14828.6 ETO03725.1 - 0.14 10.9 0.7 0.15 10.8 0.7 1.0 1 0 0 1 1 1 0 Amnionless OATP PF03137.20 ETO03725.1 - 0.19 10.0 0.2 0.22 9.7 0.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4288 PF14119.6 ETO03725.1 - 0.24 11.8 3.3 0.33 11.4 2.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4288) PRP9_N PF16958.5 ETO03725.1 - 0.59 10.1 7.0 0.88 9.6 7.0 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus YtxH PF12732.7 ETO03725.1 - 0.88 10.2 8.0 1.8 9.1 7.9 1.8 1 1 0 1 1 1 0 YtxH-like protein DUF883 PF05957.13 ETO03725.1 - 1.2 9.8 5.8 0.84 10.3 4.1 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF948 PF06103.11 ETO03725.1 - 1.2 9.4 6.8 0.17 12.2 0.8 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Cauli_AT PF03233.13 ETO03725.1 - 1.2 9.0 9.9 1.7 8.6 9.9 1.2 1 0 0 1 1 1 0 Aphid transmission protein HECT PF00632.25 ETO03726.1 - 5e-21 75.5 0.1 5.9e-21 75.2 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Ras PF00071.22 ETO03727.1 - 1.7e-28 99.3 1.0 3.5e-28 98.2 1.0 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO03727.1 - 1.5e-11 44.5 0.6 2.3e-11 44.0 0.2 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO03727.1 - 0.00065 19.2 0.1 0.0034 16.9 0.1 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family HTH_48 PF17906.1 ETO03727.1 - 0.061 13.4 0.2 0.1 12.7 0.2 1.4 1 0 0 1 1 1 0 HTH domain in Mos1 transposase RGS PF00615.19 ETO03728.1 - 0.09 13.0 0.1 0.15 12.4 0.1 1.4 1 0 0 1 1 1 0 Regulator of G protein signaling domain Pkinase PF00069.25 ETO03729.1 - 3.9e-15 55.9 0.0 4.4e-15 55.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03729.1 - 0.038 13.3 0.0 0.043 13.1 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase Zip PF02535.22 ETO03730.1 - 0.0018 17.5 3.0 0.0019 17.5 3.0 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Shisa PF13908.6 ETO03730.1 - 0.028 14.7 0.1 0.032 14.5 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SelP_N PF04592.14 ETO03730.1 - 0.031 13.7 19.6 0.042 13.3 19.6 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF929 PF06053.11 ETO03730.1 - 0.037 13.3 0.1 0.049 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) EphA2_TM PF14575.6 ETO03730.1 - 0.086 13.7 1.4 0.19 12.7 1.4 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain NicO PF03824.16 ETO03730.1 - 0.21 10.9 5.9 0.24 10.7 5.9 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein ODV-E18 PF10717.9 ETO03730.1 - 0.35 10.8 1.2 0.49 10.3 1.2 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 SARAF PF06682.12 ETO03730.1 - 0.46 10.1 3.4 2.8 7.5 3.4 1.9 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3984 PF13136.6 ETO03730.1 - 1.3 8.4 14.8 1.6 8.0 14.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3984) ANAPC4_WD40 PF12894.7 ETO03731.1 - 0.015 15.6 0.1 0.046 14.0 0.0 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO03731.1 - 0.027 15.3 0.5 6.3 7.9 0.1 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF1398 PF07166.11 ETO03731.1 - 0.1 12.7 3.6 0.14 12.2 2.7 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1398) DIX PF00778.17 ETO03731.1 - 0.13 12.1 2.6 0.64 9.9 0.8 2.3 1 1 1 2 2 2 0 DIX domain zf_CCCH_5 PF18384.1 ETO03731.1 - 0.35 11.0 0.1 0.35 11.0 0.1 1.8 2 0 0 2 2 2 0 Unkempt Zinc finger domain 1 (Znf1) ADAM_CR PF08516.12 ETO03732.1 - 0.066 13.6 0.5 0.089 13.2 0.5 1.2 1 0 0 1 1 1 0 ADAM cysteine-rich LsmAD PF06741.13 ETO03732.1 - 0.068 13.7 1.1 3.3 8.3 0.7 2.2 2 0 0 2 2 2 0 LsmAD domain Rep_fac-A_3 PF08661.11 ETO03734.1 - 0.051 13.9 0.0 0.091 13.1 0.0 1.4 1 0 0 1 1 1 0 Replication factor A protein 3 MCPVI PF02993.14 ETO03734.1 - 0.27 11.0 1.2 0.32 10.8 1.2 1.2 1 0 0 1 1 1 0 Minor capsid protein VI Pex14_N PF04695.13 ETO03734.1 - 0.46 11.1 3.5 0.57 10.8 3.4 1.3 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region FANCI_S4 PF14678.6 ETO03737.1 - 0.0017 17.5 0.1 0.0039 16.3 0.1 1.7 1 0 0 1 1 1 1 FANCI solenoid 4 DUF2670 PF10875.8 ETO03737.1 - 0.049 13.8 0.1 0.078 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) Strep_SA_rep PF06696.11 ETO03738.1 - 0.16 12.0 0.0 0.32 11.0 0.0 1.5 1 0 0 1 1 1 0 Streptococcal surface antigen repeat ubiquitin PF00240.23 ETO03739.1 - 2.9e-15 55.8 4.9 1.7e-14 53.3 4.9 2.0 1 1 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO03739.1 - 3.6e-06 26.7 3.4 1.2e-05 25.0 3.4 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO03739.1 - 0.00019 22.0 2.4 0.00024 21.6 2.4 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO03739.1 - 0.0046 17.0 1.5 0.0061 16.6 1.1 1.5 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Mucin PF01456.17 ETO03739.1 - 0.096 12.7 13.0 0.11 12.5 13.0 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4512 PF14975.6 ETO03739.1 - 0.14 12.9 2.4 0.2 12.4 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) p450 PF00067.22 ETO03739.1 - 0.46 9.2 4.4 0.45 9.2 4.4 1.1 1 0 0 1 1 1 0 Cytochrome P450 FH2 PF02181.23 ETO03740.1 - 1.5e-12 47.4 0.3 1.5e-12 47.3 0.3 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain TOPRIM_C PF16898.5 ETO03740.1 - 0.029 14.6 0.5 0.95 9.7 0.0 2.1 1 1 1 2 2 2 0 C-terminal associated domain of TOPRIM THUMP PF02926.17 ETO03740.1 - 0.067 13.3 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 THUMP domain DUF4065 PF13274.6 ETO03741.1 - 0.01 16.7 7.0 0.014 16.3 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4065) Rho_N PF07498.12 ETO03741.1 - 0.026 14.5 0.0 0.045 13.7 0.0 1.3 1 0 0 1 1 1 0 Rho termination factor, N-terminal domain DoxA PF07680.11 ETO03741.1 - 0.11 12.4 0.1 0.15 12.0 0.1 1.2 1 0 0 1 1 1 0 TQO small subunit DoxA Nop14 PF04147.12 ETO03741.1 - 0.28 9.3 21.4 0.29 9.3 21.4 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO03741.1 - 0.31 10.3 15.4 0.3 10.4 15.4 1.1 1 0 0 1 1 1 0 BUD22 HEXIM PF15313.6 ETO03741.1 - 0.33 11.2 17.1 0.64 10.2 17.1 1.5 1 1 0 1 1 1 0 Hexamethylene bis-acetamide-inducible protein CDC45 PF02724.14 ETO03741.1 - 0.44 8.8 13.4 0.41 8.9 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 ETO03741.1 - 0.95 8.4 4.6 1 8.2 4.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TFIIF_alpha PF05793.12 ETO03741.1 - 0.95 8.0 25.2 1.2 7.7 25.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) NPR3 PF03666.13 ETO03741.1 - 1 8.1 8.8 0.96 8.2 8.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PDDEXK_6 PF04720.12 ETO03741.1 - 1.1 9.2 7.8 1.3 9.0 7.8 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Pox_Ag35 PF03286.14 ETO03741.1 - 1.9 8.2 14.6 3.3 7.5 14.6 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RRN3 PF05327.11 ETO03741.1 - 3.3 6.1 20.0 3.5 6.1 20.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CPSF100_C PF13299.6 ETO03741.1 - 4.4 7.4 6.7 5.9 7.1 6.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 ETO03741.1 - 4.5 5.9 4.9 4.2 6.0 4.9 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO03741.1 - 8.3 5.1 9.5 10 4.8 9.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RNA_pol_Rpc4 PF05132.14 ETO03741.1 - 8.7 6.8 7.7 11 6.5 7.7 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 PI3K_1B_p101 PF10486.9 ETO03741.1 - 9.2 3.9 7.9 9.6 3.8 7.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NIF PF03031.18 ETO03744.1 - 1.6e-05 24.7 0.0 2.6e-05 24.0 0.0 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2608 PF11019.8 ETO03744.1 - 0.009 15.5 0.0 0.01 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2608) DUF5488 PF17590.2 ETO03745.1 - 0.058 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5488) IFT57 PF10498.9 ETO03746.1 - 0.014 14.4 15.7 0.019 14.0 15.7 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 ATG16 PF08614.11 ETO03746.1 - 0.11 12.7 26.6 0.16 12.1 26.6 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4201 PF13870.6 ETO03746.1 - 0.11 12.2 22.1 0.028 14.2 5.0 3.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Atg14 PF10186.9 ETO03746.1 - 0.15 11.1 16.9 0.18 10.9 16.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-F_leu_zip PF10473.9 ETO03746.1 - 0.16 12.0 26.2 0.27 11.3 26.2 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4763 PF15960.5 ETO03746.1 - 0.18 11.1 26.9 0.35 10.1 26.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) SAG PF04092.13 ETO03746.1 - 0.28 12.0 6.6 0.32 11.8 6.6 1.2 1 0 0 1 1 1 0 SRS domain CEP209_CC5 PF16574.5 ETO03746.1 - 0.38 10.9 20.6 0.24 11.5 8.2 2.2 1 1 1 2 2 2 0 Coiled-coil region of centrosome protein CE290 Uso1_p115_C PF04871.13 ETO03746.1 - 0.48 10.8 22.9 0.55 10.6 11.0 2.2 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4407 PF14362.6 ETO03746.1 - 0.53 9.6 8.9 0.86 8.9 8.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BLOC1_2 PF10046.9 ETO03746.1 - 1.6 9.1 16.8 0.82 10.0 8.5 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YabA PF06156.13 ETO03746.1 - 1.8 9.2 19.9 17 6.2 5.1 2.6 1 1 1 2 2 2 0 Initiation control protein YabA Phage_GPO PF05929.11 ETO03746.1 - 2 8.0 12.9 2.7 7.5 12.9 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase SpecificRecomb PF10136.9 ETO03746.1 - 2.6 6.3 9.1 3 6.0 9.1 1.1 1 0 0 1 1 1 0 Site-specific recombinase APG6_N PF17675.1 ETO03746.1 - 2.8 8.5 27.0 2.8 8.5 24.4 2.1 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETO03746.1 - 6.4 6.8 15.7 4.9 7.2 1.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ETO03746.1 - 6.6 7.2 14.8 13 6.2 1.9 3.5 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) Jnk-SapK_ap_N PF09744.9 ETO03746.1 - 7.1 6.8 26.7 10 6.3 5.6 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Cnn_1N PF07989.11 ETO03746.1 - 7.2 6.9 23.7 22 5.3 9.6 3.1 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DASH_Hsk3 PF08227.11 ETO03746.1 - 8.6 6.8 27.9 3.9 7.9 1.3 3.8 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like Exonuc_VII_L PF02601.15 ETO03746.1 - 8.9 5.8 18.2 11 5.5 18.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit bZIP_2 PF07716.15 ETO03746.1 - 9.9 6.3 26.4 0.96 9.6 1.5 4.2 4 0 0 4 4 4 0 Basic region leucine zipper HEAT PF02985.22 ETO03747.1 - 3.8e-05 23.6 4.5 0.73 10.2 0.2 4.4 4 1 0 4 4 4 2 HEAT repeat DRIM PF07539.12 ETO03747.1 - 0.018 13.4 0.2 0.29 9.4 0.0 2.0 2 0 0 2 2 2 0 Down-regulated in metastasis ADH_N PF08240.12 ETO03748.1 - 2.1e-05 24.3 0.5 3.7e-05 23.6 0.0 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ETO03748.1 - 0.083 12.8 0.1 0.17 11.8 0.1 1.7 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase DUF4578 PF15147.6 ETO03748.1 - 0.085 13.7 0.0 0.1 13.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) C2 PF00168.30 ETO03749.1 - 7.4e-05 23.0 0.1 0.00019 21.6 0.0 1.7 2 0 0 2 2 2 1 C2 domain Viral_DNA_bp PF00747.17 ETO03749.1 - 0.0098 13.1 0.0 0.011 12.9 0.0 1.0 1 0 0 1 1 1 1 ssDNA binding protein FPL PF09758.9 ETO03750.1 - 7.2e-41 139.6 5.4 8.3e-41 139.4 5.4 1.0 1 0 0 1 1 1 1 Uncharacterised conserved protein RAI16-like PF10257.9 ETO03750.1 - 0.019 13.9 0.2 0.029 13.3 0.2 1.3 1 1 0 1 1 1 0 Retinoic acid induced 16-like protein RPN2_C PF18004.1 ETO03750.1 - 0.13 12.1 4.2 0.17 11.8 4.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Protocadherin PF08374.11 ETO03750.1 - 0.3 11.0 2.3 0.33 10.9 2.3 1.1 1 0 0 1 1 1 0 Protocadherin Cation_ATPase PF13246.6 ETO03751.1 - 3.5e-08 33.4 0.2 1.3e-07 31.6 0.1 1.9 3 0 0 3 3 3 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO03751.1 - 9.6e-06 26.0 0.0 4.6e-05 23.8 0.0 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase FliG_C PF01706.16 ETO03752.1 - 0.01 16.0 1.1 0.019 15.2 1.1 1.5 1 1 0 1 1 1 0 FliG C-terminal domain ARGLU PF15346.6 ETO03752.1 - 0.039 13.8 11.8 0.18 11.7 0.6 2.2 1 1 0 2 2 2 0 Arginine and glutamate-rich 1 T3SS_basalb_I PF17001.5 ETO03752.1 - 0.071 13.7 0.6 2.7 8.7 0.6 2.1 1 1 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI Salt_tol_Pase PF09506.10 ETO03752.1 - 0.1 11.3 2.3 0.21 10.3 0.4 1.9 2 0 0 2 2 2 0 Glucosylglycerol-phosphate phosphatase (Salt_tol_Pase) SIR4_SID PF16991.5 ETO03752.1 - 0.17 11.9 5.3 1.5 8.8 0.6 2.1 1 1 1 2 2 2 0 Sir4 SID domain DGCR6 PF07324.11 ETO03752.1 - 0.22 11.2 6.9 1.2 8.7 6.9 1.9 1 1 0 1 1 1 0 DiGeorge syndrome critical region 6 (DGCR6) protein DUF3829 PF12889.7 ETO03753.1 - 0.0011 18.5 5.2 0.0015 18.1 5.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3829) DUF4798 PF16055.5 ETO03753.1 - 2.1 8.7 9.8 14 6.0 9.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4798) Calpain_inhib PF00748.19 ETO03754.1 - 0.0093 16.5 0.9 0.012 16.1 0.9 1.1 1 0 0 1 1 1 1 Calpain inhibitor DUF4834 PF16118.5 ETO03756.1 - 0.00088 20.2 1.4 0.0014 19.5 1.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) 7tm_1 PF00001.21 ETO03756.1 - 0.052 12.9 0.9 0.064 12.6 0.9 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) DUF4191 PF13829.6 ETO03756.1 - 1.2 8.4 7.7 1.7 7.9 7.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Mito_carr PF00153.27 ETO03758.1 - 6e-06 26.1 0.4 7.7e-06 25.7 0.4 1.2 1 0 0 1 1 1 1 Mitochondrial carrier protein DDE_Tnp_1 PF01609.21 ETO03760.1 - 1e-17 64.5 0.2 1.5e-17 64.0 0.2 1.1 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_2 PF13586.6 ETO03760.1 - 0.023 15.1 0.0 6.9 7.1 0.0 2.7 3 0 0 3 3 3 0 Transposase DDE domain DEAD PF00270.29 ETO03761.1 - 4.4e-09 36.4 0.2 1.5e-08 34.6 0.1 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase CMS1 PF14617.6 ETO03761.1 - 0.00016 21.1 0.1 0.00019 20.8 0.1 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DUF3879 PF12995.7 ETO03762.1 - 0.0073 16.0 0.9 0.78 9.4 0.1 2.3 2 1 0 2 2 2 2 Domain of unknown function, E. rectale Gene description (DUF3879) GAS2 PF02187.17 ETO03763.1 - 2.1e-06 27.7 0.0 3.8e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Growth-Arrest-Specific Protein 2 Domain PKcGMP_CC PF16808.5 ETO03763.1 - 1.5e-05 24.8 13.4 0.00015 21.5 1.6 3.5 2 1 1 3 3 3 1 Coiled-coil N-terminus of cGMP-dependent protein kinase ATG16 PF08614.11 ETO03763.1 - 8e-05 23.0 2.2 0.00014 22.1 2.2 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 ETO03763.1 - 0.00012 22.1 1.8 0.00023 21.2 1.8 1.4 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO03763.1 - 0.00045 19.2 2.3 0.00069 18.6 2.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein VGPC1_C PF16799.5 ETO03763.1 - 0.00061 19.7 2.6 0.0013 18.6 0.8 2.3 2 0 0 2 2 2 1 C-terminal membrane-localisation domain of ion-channel, VCN1 Rab5-bind PF09311.11 ETO03763.1 - 0.00083 18.8 2.1 0.0013 18.2 2.1 1.2 1 0 0 1 1 1 1 Rabaptin-like protein AAA_13 PF13166.6 ETO03763.1 - 0.00099 17.9 3.3 0.0014 17.4 3.3 1.1 1 0 0 1 1 1 1 AAA domain DUF641 PF04859.12 ETO03763.1 - 0.001 19.4 2.4 0.002 18.4 2.4 1.5 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) Seryl_tRNA_N PF02403.22 ETO03763.1 - 0.0014 18.8 4.0 0.003 17.8 4.0 1.5 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain HrpB7 PF09486.10 ETO03763.1 - 0.0015 18.9 3.3 0.0026 18.1 3.3 1.4 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) HOOK PF05622.12 ETO03763.1 - 0.0024 16.1 1.0 0.0033 15.6 1.0 1.1 1 0 0 1 1 1 1 HOOK protein KASH_CCD PF14662.6 ETO03763.1 - 0.0026 17.6 4.0 0.0041 17.0 4.0 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF2203 PF09969.9 ETO03763.1 - 0.0033 18.1 1.4 0.007 17.1 1.4 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2203) Cep57_MT_bd PF06657.13 ETO03763.1 - 0.0041 17.5 3.6 0.011 16.2 3.6 1.7 1 1 0 1 1 1 1 Centrosome microtubule-binding domain of Cep57 ADIP PF11559.8 ETO03763.1 - 0.0043 17.2 0.8 0.008 16.3 0.8 1.4 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding Atg14 PF10186.9 ETO03763.1 - 0.005 16.0 1.1 0.0067 15.5 1.1 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 SlyX PF04102.12 ETO03763.1 - 0.0052 17.4 2.9 0.0052 17.4 2.9 2.9 2 1 1 3 3 2 1 SlyX BRE1 PF08647.11 ETO03763.1 - 0.0058 16.7 2.7 0.0092 16.0 0.9 1.9 2 0 0 2 2 2 1 BRE1 E3 ubiquitin ligase GrpE PF01025.19 ETO03763.1 - 0.0059 16.3 3.9 0.0059 16.3 3.9 1.8 2 0 0 2 2 2 1 GrpE Angiomotin_C PF12240.8 ETO03763.1 - 0.0063 16.1 1.3 0.0063 16.1 1.3 1.7 2 0 0 2 2 1 1 Angiomotin C terminal UPF0242 PF06785.11 ETO03763.1 - 0.0069 16.5 1.3 0.013 15.6 1.3 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF812 PF05667.11 ETO03763.1 - 0.0085 15.0 2.0 0.013 14.4 2.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF4407 PF14362.6 ETO03763.1 - 0.01 15.2 1.0 0.016 14.6 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HIP1_clath_bdg PF16515.5 ETO03763.1 - 0.011 16.3 0.7 0.011 16.3 0.7 1.5 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF5082 PF16888.5 ETO03763.1 - 0.012 15.9 5.5 0.08 13.2 1.7 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) Spc24 PF08286.11 ETO03763.1 - 0.012 15.8 0.6 0.029 14.6 0.6 1.7 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DUF3450 PF11932.8 ETO03763.1 - 0.015 14.6 1.1 0.028 13.7 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) GAS PF13851.6 ETO03763.1 - 0.016 14.6 4.1 0.028 13.8 4.1 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding HMMR_N PF15905.5 ETO03763.1 - 0.02 14.4 1.6 0.031 13.8 1.6 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DASH_Spc34 PF08657.10 ETO03763.1 - 0.021 14.6 0.3 0.038 13.8 0.3 1.4 1 0 0 1 1 1 0 DASH complex subunit Spc34 FmiP_Thoc5 PF09766.9 ETO03763.1 - 0.022 14.1 0.3 0.03 13.6 0.3 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 TMF_DNA_bd PF12329.8 ETO03763.1 - 0.023 14.7 9.2 0.023 14.7 9.2 2.3 2 1 0 2 2 1 0 TATA element modulatory factor 1 DNA binding FapA PF03961.13 ETO03763.1 - 0.028 13.1 1.3 0.04 12.5 1.3 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 ETO03763.1 - 0.028 13.7 0.1 0.041 13.1 0.1 1.2 1 0 0 1 1 1 0 TMPIT-like protein CALCOCO1 PF07888.11 ETO03763.1 - 0.03 13.2 3.9 0.04 12.8 3.9 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF2046 PF09755.9 ETO03763.1 - 0.034 13.4 2.8 0.051 12.8 2.8 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein H4 (DUF2046) Fez1 PF06818.15 ETO03763.1 - 0.035 14.5 0.4 0.062 13.8 0.4 1.4 1 0 0 1 1 1 0 Fez1 FPP PF05911.11 ETO03763.1 - 0.036 12.3 3.7 0.048 11.9 3.7 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil NPV_P10 PF05531.12 ETO03763.1 - 0.037 14.5 0.4 0.07 13.6 0.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein CC2-LZ PF16516.5 ETO03763.1 - 0.041 14.2 2.6 0.086 13.2 2.6 1.5 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Fib_alpha PF08702.10 ETO03763.1 - 0.043 14.0 1.6 0.043 14.0 1.6 1.9 2 1 0 2 2 1 0 Fibrinogen alpha/beta chain family FAM76 PF16046.5 ETO03763.1 - 0.045 13.1 1.6 0.069 12.5 1.6 1.2 1 0 0 1 1 1 0 FAM76 protein Laminin_II PF06009.12 ETO03763.1 - 0.05 13.6 1.6 0.061 13.3 0.5 1.7 2 0 0 2 2 1 0 Laminin Domain II bZIP_1 PF00170.21 ETO03763.1 - 0.053 13.6 5.5 2.8 8.1 1.2 2.5 1 1 1 2 2 2 0 bZIP transcription factor Helo_like_N PF17111.5 ETO03763.1 - 0.06 12.7 0.2 0.1 11.9 0.2 1.3 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins Histone_HNS PF00816.21 ETO03763.1 - 0.061 14.1 1.8 0.061 14.1 1.8 2.1 2 1 0 2 2 2 0 H-NS histone family YojJ PF10372.9 ETO03763.1 - 0.07 13.2 0.8 0.21 11.7 0.1 2.1 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus CorA PF01544.18 ETO03763.1 - 0.073 12.4 1.8 0.11 11.8 1.8 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein bZIP_2 PF07716.15 ETO03763.1 - 0.074 13.1 0.2 0.074 13.1 0.2 2.6 2 1 1 3 3 2 0 Basic region leucine zipper DUF3584 PF12128.8 ETO03763.1 - 0.077 10.5 0.9 0.1 10.1 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) BST2 PF16716.5 ETO03763.1 - 0.083 13.5 0.8 0.083 13.5 0.8 1.7 2 0 0 2 2 1 0 Bone marrow stromal antigen 2 DUF1664 PF07889.12 ETO03763.1 - 0.084 12.9 0.4 0.15 12.1 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO03763.1 - 0.087 13.4 10.5 0.052 14.1 7.0 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region TMF_TATA_bd PF12325.8 ETO03763.1 - 0.099 12.9 4.3 0.23 11.7 4.3 1.5 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF2481 PF10654.9 ETO03763.1 - 0.1 12.6 0.3 0.2 11.6 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2481) TolA_bind_tri PF16331.5 ETO03763.1 - 0.11 12.6 4.4 0.19 11.8 0.8 2.6 2 1 1 3 3 2 0 TolA binding protein trimerisation YabA PF06156.13 ETO03763.1 - 0.13 12.9 0.6 0.24 12.1 0.6 1.4 1 0 0 1 1 1 0 Initiation control protein YabA DUF4239 PF14023.6 ETO03763.1 - 0.13 12.0 0.2 0.19 11.4 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) MIP-T3_C PF17749.1 ETO03763.1 - 0.13 12.2 2.7 0.27 11.2 2.7 1.6 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region End3 PF12761.7 ETO03763.1 - 0.14 12.3 1.3 0.29 11.3 1.3 1.5 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 HlyD_2 PF12700.7 ETO03763.1 - 0.15 10.8 2.9 0.26 10.0 2.9 1.3 1 0 0 1 1 1 0 HlyD family secretion protein Hormone_4 PF00220.17 ETO03763.1 - 0.15 12.1 0.8 0.34 11.0 0.8 1.5 1 0 0 1 1 1 0 Neurohypophysial hormones, N-terminal Domain DUF16 PF01519.16 ETO03763.1 - 0.17 12.4 2.5 0.16 12.4 0.7 2.0 2 0 0 2 2 1 0 Protein of unknown function DUF16 DUF465 PF04325.13 ETO03763.1 - 0.33 11.0 9.1 0.91 9.6 9.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF465) Cut12 PF11500.8 ETO03763.1 - 0.37 10.8 5.3 1.9 8.5 3.7 2.2 1 1 1 2 2 2 0 Spindle pole body formation-associated protein Med9 PF07544.13 ETO03763.1 - 0.45 10.6 4.2 1.9 8.7 4.2 2.1 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 FlaC_arch PF05377.11 ETO03763.1 - 0.47 10.9 5.5 0.46 10.9 2.3 2.5 2 1 1 3 3 1 0 Flagella accessory protein C (FlaC) HAUS5 PF14817.6 ETO03763.1 - 0.64 8.7 3.5 0.88 8.3 3.5 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 HAUS-augmin3 PF14932.6 ETO03763.1 - 0.67 9.5 3.5 0.33 10.5 1.4 1.5 2 0 0 2 2 1 0 HAUS augmin-like complex subunit 3 DivIC PF04977.15 ETO03763.1 - 0.75 9.6 13.6 0.059 13.1 1.9 2.5 2 1 1 3 3 2 0 Septum formation initiator MutS_IV PF05190.18 ETO03763.1 - 1.2 9.5 9.7 8.1 6.9 0.6 3.1 2 1 1 3 3 3 0 MutS family domain IV ABC_tran_CTD PF16326.5 ETO03763.1 - 1.7 9.0 19.4 0.74 10.1 15.3 2.4 2 1 0 2 2 1 0 ABC transporter C-terminal domain Swi5 PF07061.11 ETO03763.1 - 1.9 8.6 5.8 2.2 8.4 3.6 2.2 2 1 0 2 2 1 0 Swi5 XhlA PF10779.9 ETO03763.1 - 2 8.7 10.6 0.78 10.0 0.5 2.7 2 1 2 4 4 3 0 Haemolysin XhlA DUF1192 PF06698.11 ETO03763.1 - 2.1 8.5 15.2 0.23 11.6 3.0 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1192) DUF4315 PF14193.6 ETO03763.1 - 2.3 8.3 9.7 26 4.9 9.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4315) ZapB PF06005.12 ETO03763.1 - 3.7 8.1 11.9 0.52 10.8 7.6 1.9 2 1 0 2 2 1 0 Cell division protein ZapB MerR-DNA-bind PF09278.11 ETO03763.1 - 3.7 8.1 11.4 11 6.7 3.7 2.6 1 1 1 2 2 2 0 MerR, DNA binding Prefoldin_2 PF01920.20 ETO03763.1 - 4.1 7.4 9.1 0.24 11.4 2.8 2.2 2 1 0 2 2 1 0 Prefoldin subunit DUF4140 PF13600.6 ETO03763.1 - 6.3 7.3 9.4 1.9 9.0 3.5 2.6 2 1 1 3 3 2 0 N-terminal domain of unknown function (DUF4140) BMFP PF04380.13 ETO03763.1 - 6.8 7.3 10.4 0.39 11.2 1.7 2.8 3 0 0 3 3 2 0 Membrane fusogenic activity Prefoldin PF02996.17 ETO03763.1 - 7.2 6.6 11.2 2e+02 1.9 0.2 2.9 2 2 0 2 2 2 0 Prefoldin subunit Matrilin_ccoil PF10393.9 ETO03763.1 - 8.3 6.4 7.9 25 4.8 0.3 3.1 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin GGDEF PF00990.21 ETO03764.1 - 2.1e-05 24.3 0.0 2.8e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain ZapB PF06005.12 ETO03768.1 - 0.048 14.1 0.1 0.11 12.9 0.0 1.6 2 0 0 2 2 2 0 Cell division protein ZapB ArgoN PF16486.5 ETO03769.1 - 0.053 14.1 0.1 0.082 13.5 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of argonaute DUF4175 PF13779.6 ETO03771.1 - 0.5 8.2 5.6 0.57 8.0 5.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) UPF0242 PF06785.11 ETO03774.1 - 0.00024 21.3 9.0 0.00029 21.0 9.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus HR1 PF02185.16 ETO03774.1 - 0.00038 20.5 7.1 0.00038 20.5 7.1 2.2 1 1 1 2 2 2 1 Hr1 repeat DUF16 PF01519.16 ETO03774.1 - 0.0011 19.4 8.3 0.0014 19.1 7.5 1.4 1 1 0 1 1 1 1 Protein of unknown function DUF16 AAA_13 PF13166.6 ETO03774.1 - 0.0018 17.0 5.7 0.0021 16.8 5.7 1.0 1 0 0 1 1 1 1 AAA domain DUF3584 PF12128.8 ETO03774.1 - 0.0091 13.6 8.1 0.011 13.4 8.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Spc7 PF08317.11 ETO03774.1 - 0.02 13.8 11.4 0.026 13.4 11.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4168 PF13767.6 ETO03774.1 - 0.022 15.9 3.1 0.022 15.9 3.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4168) RNase_3_N PF18497.1 ETO03774.1 - 0.025 14.8 4.7 0.14 12.4 3.7 2.1 1 1 1 2 2 2 0 Ribonuclease III N-terminal domain DUF3829 PF12889.7 ETO03774.1 - 0.042 13.3 6.8 1.2 8.6 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3829) Exonuc_VII_L PF02601.15 ETO03774.1 - 0.049 13.2 8.1 0.062 12.9 8.1 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_23 PF13476.6 ETO03774.1 - 0.05 14.1 5.2 0.059 13.9 5.2 1.1 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.9 ETO03774.1 - 0.051 12.7 9.4 0.056 12.5 9.4 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 ETO03774.1 - 0.08 12.2 9.4 0.11 11.8 9.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein SHE3 PF17078.5 ETO03774.1 - 0.1 12.3 9.4 0.16 11.7 9.4 1.4 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 CCP_MauG PF03150.14 ETO03774.1 - 0.11 13.1 0.6 0.12 13.0 0.6 1.1 1 0 0 1 1 1 0 Di-haem cytochrome c peroxidase FapA PF03961.13 ETO03774.1 - 0.11 11.1 3.7 0.13 10.9 3.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A MtrB PF05440.12 ETO03774.1 - 0.12 12.8 0.6 0.92 10.0 0.2 2.1 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF948 PF06103.11 ETO03774.1 - 0.14 12.5 5.1 0.59 10.4 0.6 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) PolyA_pol PF01743.20 ETO03774.1 - 0.2 12.1 2.3 0.29 11.6 1.8 1.5 1 1 0 1 1 1 0 Poly A polymerase head domain CobA_CobO_BtuR PF02572.15 ETO03774.1 - 0.21 11.8 3.0 0.27 11.5 3.0 1.1 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Snapin_Pallidin PF14712.6 ETO03774.1 - 0.22 12.0 10.6 1.6 9.2 5.1 2.2 1 1 1 2 2 2 0 Snapin/Pallidin TYW3 PF02676.14 ETO03774.1 - 0.23 10.8 3.4 0.83 9.0 0.4 2.0 1 1 1 2 2 2 0 Methyltransferase TYW3 DUF1178 PF06676.11 ETO03774.1 - 0.25 11.7 5.6 0.24 11.8 4.4 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1178) T3SSipB PF16535.5 ETO03774.1 - 0.25 11.8 7.6 1.8 9.1 7.5 1.9 1 1 0 1 1 1 0 Type III cell invasion protein SipB DUF4226 PF10774.9 ETO03774.1 - 0.25 11.6 5.4 6.9 7.0 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4226) OmpH PF03938.14 ETO03774.1 - 0.34 11.2 11.9 0.55 10.6 11.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Fib_alpha PF08702.10 ETO03774.1 - 0.36 11.0 8.2 0.52 10.5 8.2 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family CLZ PF16526.5 ETO03774.1 - 0.37 11.2 8.4 3.6 8.0 3.7 2.8 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Stathmin PF00836.19 ETO03774.1 - 0.41 10.6 10.8 0.57 10.1 10.8 1.2 1 0 0 1 1 1 0 Stathmin family JIP_LZII PF16471.5 ETO03774.1 - 0.75 10.0 7.3 2 8.6 7.3 1.8 1 1 0 1 1 1 0 JNK-interacting protein leucine zipper II Mt_ATP-synt_D PF05873.12 ETO03774.1 - 0.79 9.6 7.5 1 9.2 2.0 1.9 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) NPV_P10 PF05531.12 ETO03774.1 - 0.9 10.1 3.8 7.9 7.0 4.3 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.5 ETO03774.1 - 1.5 9.1 10.6 42 4.5 10.7 2.5 1 1 0 1 1 1 0 ABC transporter C-terminal domain XhlA PF10779.9 ETO03774.1 - 1.6 9.0 5.4 6.5 7.0 0.5 2.3 1 1 0 2 2 2 0 Haemolysin XhlA ACCA PF03255.14 ETO03774.1 - 2.3 8.1 8.6 0.94 9.4 3.7 2.0 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Methyltransf_24 PF13578.6 ETO03776.1 - 2.3e-09 38.2 0.0 3.5e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain PCP_red PF08369.10 ETO03776.1 - 0.038 14.2 0.9 0.076 13.2 0.9 1.5 1 0 0 1 1 1 0 Proto-chlorophyllide reductase 57 kD subunit Spc29 PF17082.5 ETO03777.1 - 0.00056 19.8 7.2 0.00064 19.6 7.2 1.0 1 0 0 1 1 1 1 Spindle Pole Component 29 Fez1 PF06818.15 ETO03777.1 - 0.0014 19.1 21.0 0.011 16.2 21.0 1.9 1 1 0 1 1 1 1 Fez1 Myosin_tail_1 PF01576.19 ETO03777.1 - 0.0022 15.9 21.8 0.0028 15.6 21.8 1.1 1 0 0 1 1 1 1 Myosin tail ATG16 PF08614.11 ETO03777.1 - 0.0069 16.6 21.5 0.0093 16.2 21.5 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) BRE1 PF08647.11 ETO03777.1 - 0.016 15.3 22.9 0.022 14.8 19.9 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase PRKG1_interact PF15898.5 ETO03777.1 - 0.017 16.0 24.3 0.14 13.0 6.7 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain BLI1 PF17324.2 ETO03777.1 - 0.018 15.7 5.6 0.018 15.7 5.6 2.1 1 1 1 2 2 2 0 BLOC-1 interactor 1 ZapB PF06005.12 ETO03777.1 - 0.023 15.1 19.4 0.023 15.1 19.4 2.2 1 1 1 2 2 2 0 Cell division protein ZapB Spc7 PF08317.11 ETO03777.1 - 0.035 13.0 22.8 0.046 12.6 22.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein RasGAP_C PF03836.15 ETO03777.1 - 0.059 13.5 12.9 0.14 12.4 12.9 1.6 1 1 0 1 1 1 0 RasGAP C-terminus TMPIT PF07851.13 ETO03777.1 - 0.063 12.5 11.7 0.076 12.3 11.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein AAA_13 PF13166.6 ETO03777.1 - 0.07 11.8 14.3 0.078 11.6 14.3 1.0 1 0 0 1 1 1 0 AAA domain YscO-like PF16789.5 ETO03777.1 - 0.14 12.2 22.1 0.042 13.9 11.3 2.0 1 1 1 2 2 2 0 YscO-like protein DUF5129 PF17173.4 ETO03777.1 - 0.15 11.2 3.5 0.17 10.9 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) DUF3450 PF11932.8 ETO03777.1 - 0.16 11.3 19.4 0.29 10.4 18.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Rabaptin PF03528.15 ETO03777.1 - 0.26 10.0 14.4 0.31 9.7 14.4 1.1 1 0 0 1 1 1 0 Rabaptin DUF1664 PF07889.12 ETO03777.1 - 0.27 11.3 9.7 0.4 10.7 9.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FTO_NTD PF12933.7 ETO03777.1 - 0.31 10.3 5.8 0.35 10.1 5.8 1.2 1 0 0 1 1 1 0 FTO catalytic domain EzrA PF06160.12 ETO03777.1 - 0.41 8.8 20.7 0.5 8.5 20.7 1.0 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA FAM76 PF16046.5 ETO03777.1 - 0.44 9.9 16.3 2.3 7.5 16.3 1.8 1 1 0 1 1 1 0 FAM76 protein UPF0242 PF06785.11 ETO03777.1 - 0.5 10.4 24.4 0.62 10.1 24.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 ETO03777.1 - 0.7 10.1 15.3 1.7 8.8 9.2 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SKA1 PF07160.12 ETO03777.1 - 0.8 9.5 16.9 2.3 8.0 16.9 1.6 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Cluap1 PF10234.9 ETO03777.1 - 0.87 8.9 19.9 4 6.7 19.9 1.8 1 1 0 1 1 1 0 Clusterin-associated protein-1 DUF4407 PF14362.6 ETO03777.1 - 0.91 8.8 14.0 1.3 8.3 14.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DASH_Dam1 PF08653.10 ETO03777.1 - 0.92 9.4 4.3 2.4 8.0 0.6 2.3 2 0 0 2 2 2 0 DASH complex subunit Dam1 ERM PF00769.19 ETO03777.1 - 1 9.1 30.5 0.047 13.5 20.7 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family OmpH PF03938.14 ETO03777.1 - 1 9.7 27.3 5.8 7.2 27.3 1.9 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Tropomyosin_1 PF12718.7 ETO03777.1 - 1.1 9.4 29.1 1.4 9.1 24.5 2.1 1 1 1 2 2 2 0 Tropomyosin like Nmad5 PF18757.1 ETO03777.1 - 1.2 9.3 10.7 4.4 7.5 10.7 1.8 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 HIP1_clath_bdg PF16515.5 ETO03777.1 - 1.5 9.5 21.8 1.7 9.3 20.2 1.8 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 BST2 PF16716.5 ETO03777.1 - 1.6 9.4 21.1 9.9 6.8 4.8 2.7 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Prominin PF05478.11 ETO03777.1 - 1.8 6.4 9.8 2.3 6.1 9.8 1.1 1 0 0 1 1 1 0 Prominin FapA PF03961.13 ETO03777.1 - 2.3 6.7 15.0 2.5 6.6 15.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Herpes_UL6 PF01763.16 ETO03777.1 - 2.7 6.4 10.5 3.2 6.2 10.5 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Fzo_mitofusin PF04799.13 ETO03777.1 - 2.8 7.5 15.1 6.2 6.4 5.8 2.1 1 1 1 2 2 2 0 fzo-like conserved region DUF3584 PF12128.8 ETO03777.1 - 3.1 5.2 22.5 3.4 5.0 22.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) HrpB7 PF09486.10 ETO03777.1 - 3.1 8.2 16.4 9.9 6.5 5.2 2.0 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Golgin_A5 PF09787.9 ETO03777.1 - 3.4 7.1 24.6 0.43 10.0 18.2 1.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 Laminin_II PF06009.12 ETO03777.1 - 3.5 7.6 13.7 2.5 8.1 9.8 1.9 1 1 0 1 1 1 0 Laminin Domain II KELK PF15796.5 ETO03777.1 - 3.6 8.1 23.1 0.56 10.7 16.5 2.4 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase MAS20 PF02064.15 ETO03777.1 - 4.1 7.5 13.6 0.39 10.8 8.5 1.7 1 1 1 2 2 2 0 MAS20 protein import receptor ADIP PF11559.8 ETO03777.1 - 5.4 7.1 23.8 6.3 6.9 14.3 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Nas2_N PF18265.1 ETO03777.1 - 5.6 7.0 15.5 25 4.9 10.4 2.9 1 1 1 2 2 2 0 Nas2 N_terminal domain Lectin_N PF03954.14 ETO03777.1 - 5.7 6.7 10.5 1.2e+02 2.4 10.6 2.1 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain APG6_N PF17675.1 ETO03777.1 - 6 7.4 28.8 17 6.0 28.8 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region Mod_r PF07200.13 ETO03777.1 - 6.1 6.9 24.3 1.9 8.6 14.4 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4446 PF14584.6 ETO03777.1 - 6.2 6.8 13.8 3.5 7.6 9.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Jnk-SapK_ap_N PF09744.9 ETO03777.1 - 6.2 7.0 26.0 46 4.2 25.3 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4298 PF14131.6 ETO03777.1 - 6.6 6.8 13.9 1.4 8.9 1.0 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4298) LUC7 PF03194.15 ETO03777.1 - 7.3 6.2 16.9 9.2 5.8 16.9 1.1 1 0 0 1 1 1 0 LUC7 N_terminus YjcZ PF13990.6 ETO03777.1 - 9 5.6 8.9 2.7 7.3 5.0 1.8 1 1 1 2 2 2 0 YjcZ-like protein V_ATPase_I PF01496.19 ETO03777.1 - 9.5 4.0 14.7 11 3.7 14.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Atg14 PF10186.9 ETO03777.1 - 9.8 5.1 14.2 13 4.7 14.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 ETO03777.1 - 10 5.9 19.5 12 5.6 18.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Ank_2 PF12796.7 ETO03778.1 - 2.8e-18 66.3 2.0 5.3e-10 39.8 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO03778.1 - 1e-15 57.6 0.2 6e-09 36.0 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO03778.1 - 1.9e-13 50.6 0.0 0.0001 22.8 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO03778.1 - 3.5e-11 42.3 0.0 0.049 14.2 0.0 5.0 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ETO03778.1 - 7.1e-11 42.0 0.0 0.0067 16.8 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat ATP-synt_E_2 PF08112.11 ETO03779.1 - 0.25 11.6 1.7 2 8.8 0.2 2.4 3 0 0 3 3 3 0 ATP synthase epsilon subunit Pkinase PF00069.25 ETO03780.1 - 1.5e-21 76.9 0.0 1.8e-21 76.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03780.1 - 2.4e-07 30.3 0.0 2.9e-07 30.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3439 PF11921.8 ETO03781.1 - 0.011 15.7 0.8 0.014 15.3 0.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ThiF PF00899.21 ETO03781.1 - 0.023 14.1 0.1 0.027 13.8 0.1 1.1 1 0 0 1 1 1 0 ThiF family DUF599 PF04654.12 ETO03781.1 - 0.076 12.4 0.1 0.1 12.0 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF599 EVI2A PF05399.11 ETO03782.1 - 0.0046 16.6 0.1 0.0055 16.3 0.1 1.1 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) DEAD PF00270.29 ETO03783.1 - 6.5e-24 84.6 0.0 7.1e-24 84.5 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Neuropeptide_S PF14993.6 ETO03783.1 - 0.0032 17.3 0.0 0.0059 16.4 0.0 1.4 1 0 0 1 1 1 1 Neuropeptide S precursor protein ResIII PF04851.15 ETO03783.1 - 0.019 14.9 0.0 0.022 14.8 0.0 1.1 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF1924 PF09086.11 ETO03784.1 - 0.14 12.5 0.9 0.31 11.4 0.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1924) Homeodomain PF00046.29 ETO03788.1 - 0.011 15.5 0.1 0.028 14.2 0.1 1.6 1 0 0 1 1 1 0 Homeodomain NOA36 PF06524.12 ETO03789.1 - 1 8.6 9.4 1.2 8.4 9.4 1.1 1 0 0 1 1 1 0 NOA36 protein LptF_LptG PF03739.14 ETO03790.1 - 0.0017 17.3 0.1 0.0017 17.2 0.1 1.1 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG Neur_chan_LBD PF02931.23 ETO03790.1 - 0.02 14.3 0.3 0.028 13.9 0.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel ligand binding domain Neur_chan_memb PF02932.16 ETO03790.1 - 0.036 14.1 0.1 0.056 13.5 0.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4149 PF13664.6 ETO03790.1 - 0.074 13.4 0.5 0.11 12.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) Ribosomal_L19 PF01245.20 ETO03791.1 - 2.6e-45 152.9 2.7 5.1e-45 152.0 2.7 1.5 1 0 0 1 1 1 1 Ribosomal protein L19 tRNA_m1G_MT PF01746.21 ETO03791.1 - 1e-39 136.3 0.0 1.6e-39 135.6 0.0 1.2 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Ribosomal_S16 PF00886.19 ETO03791.1 - 4e-25 87.7 0.1 8.5e-25 86.6 0.1 1.6 1 0 0 1 1 1 1 Ribosomal protein S16 RimM PF01782.18 ETO03791.1 - 3.5e-18 65.6 0.1 3.1e-17 62.5 0.0 2.6 3 0 0 3 3 3 1 RimM N-terminal domain XisI PF08869.11 ETO03791.1 - 0.016 15.5 0.1 0.21 11.9 0.0 2.3 2 0 0 2 2 2 0 XisI protein Tubulin_C PF03953.17 ETO03792.1 - 9e-43 145.4 0.0 1.2e-42 145.0 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain AAA PF00004.29 ETO03793.1 - 7.6e-11 42.6 0.0 8.5e-11 42.4 0.0 1.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zot PF05707.12 ETO03793.1 - 0.0021 17.7 0.0 0.0021 17.7 0.0 1.1 1 0 0 1 1 1 1 Zonular occludens toxin (Zot) Plant_vir_prot PF01307.17 ETO03794.1 - 0.048 13.9 0.0 0.05 13.8 0.0 1.1 1 0 0 1 1 1 0 Plant viral movement protein DUF1951 PF09188.10 ETO03794.1 - 0.21 11.6 5.5 0.32 11.0 5.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF1951) TolA_bind_tri PF16331.5 ETO03797.1 - 0.00064 19.7 0.4 0.00091 19.3 0.4 1.3 1 0 0 1 1 1 1 TolA binding protein trimerisation KLRAQ PF10205.9 ETO03797.1 - 0.017 15.4 2.7 0.033 14.4 2.7 1.5 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein LLC1 PF14945.6 ETO03797.1 - 0.02 15.5 0.6 0.022 15.3 0.6 1.1 1 0 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein UPF0242 PF06785.11 ETO03797.1 - 0.025 14.7 4.1 0.027 14.6 4.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 ETO03797.1 - 0.037 13.4 4.3 0.044 13.1 4.3 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Med9 PF07544.13 ETO03797.1 - 0.04 14.0 2.4 0.057 13.5 2.4 1.3 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 TMF_DNA_bd PF12329.8 ETO03797.1 - 0.069 13.2 8.0 1 9.4 3.0 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding HIP1_clath_bdg PF16515.5 ETO03797.1 - 0.072 13.7 4.0 0.082 13.5 4.0 1.1 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DHR10 PF18595.1 ETO03797.1 - 0.15 12.1 4.5 0.14 12.2 0.9 1.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain TPR_1 PF00515.28 ETO03799.1 - 3.6e-09 36.1 0.7 6.2e-09 35.3 0.7 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03799.1 - 6.8e-08 32.1 0.2 1.3e-07 31.1 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03799.1 - 3.6e-07 29.9 0.8 8.7e-07 28.7 0.8 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat Sororin PF09666.10 ETO03799.1 - 0.00059 20.1 0.2 0.00069 19.9 0.2 1.2 1 0 0 1 1 1 1 Sororin protein TPR_19 PF14559.6 ETO03799.1 - 0.005 17.3 0.1 0.0092 16.5 0.1 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03799.1 - 0.009 16.3 4.6 0.11 13.0 0.0 2.7 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03799.1 - 0.016 15.8 0.1 0.032 14.9 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03799.1 - 0.033 13.9 0.1 6.7 6.5 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_7 PF13176.6 ETO03799.1 - 0.038 14.0 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO03799.1 - 0.043 14.1 0.2 0.091 13.1 0.0 1.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Mad3_BUB1_I_2 PF17014.5 ETO03799.1 - 0.048 13.8 0.1 0.063 13.4 0.1 1.2 1 0 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein NARP1 PF12569.8 ETO03799.1 - 0.083 11.8 0.0 0.083 11.8 0.0 2.0 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 Bcl-2_BAD PF10514.9 ETO03799.1 - 0.65 10.5 5.9 1.1 9.7 5.8 1.5 1 1 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD AA_permease PF00324.21 ETO03801.1 - 1.2e-06 27.4 0.6 1.1e-05 24.3 0.6 1.9 1 1 0 1 1 1 1 Amino acid permease DUF423 PF04241.15 ETO03801.1 - 0.093 12.9 0.0 0.22 11.7 0.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF423) Cor1 PF04803.12 ETO03802.1 - 0.00085 19.5 4.4 0.0011 19.2 4.4 1.1 1 0 0 1 1 1 1 Cor1/Xlr/Xmr conserved region UPF0184 PF03670.13 ETO03802.1 - 0.035 14.5 0.2 0.046 14.1 0.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF2240 PF09999.9 ETO03802.1 - 0.057 13.0 0.2 0.075 12.7 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) GCN5L1 PF06320.13 ETO03802.1 - 0.08 13.1 4.9 0.096 12.8 4.9 1.2 1 0 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) CorA PF01544.18 ETO03802.1 - 0.16 11.3 0.4 0.16 11.3 0.4 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein AP3D1 PF06375.11 ETO03802.1 - 0.18 12.0 9.0 0.21 11.8 9.0 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Alpha-2-MRAP_C PF06401.11 ETO03802.1 - 0.73 9.8 8.4 0.99 9.3 8.4 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain 2OG-FeII_Oxy_5 PF13759.6 ETO03804.1 - 3.5e-06 27.3 0.0 7.6e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Cupin_2 PF07883.11 ETO03804.1 - 0.017 14.8 0.0 0.033 13.9 0.0 1.6 1 1 0 1 1 1 0 Cupin domain CHAP PF05257.16 ETO03804.1 - 0.029 14.9 0.1 0.065 13.8 0.1 1.8 1 1 0 1 1 1 0 CHAP domain 2OG-FeII_Oxy_3 PF13640.6 ETO03804.1 - 0.047 14.6 0.0 0.064 14.1 0.0 1.3 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily G-alpha PF00503.20 ETO03806.1 - 1.4e-14 54.1 0.1 1.4e-14 54.1 0.1 1.7 1 1 1 2 2 2 1 G-protein alpha subunit FancD2 PF14631.6 ETO03806.1 - 0.0029 15.1 0.9 0.0035 14.9 0.9 1.1 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease Zip PF02535.22 ETO03806.1 - 0.0095 15.2 0.5 0.014 14.7 0.5 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Mpp10 PF04006.12 ETO03806.1 - 0.031 12.7 13.0 0.051 12.0 13.0 1.2 1 0 0 1 1 1 0 Mpp10 protein RNA_pol_Rpc4 PF05132.14 ETO03806.1 - 0.064 13.7 0.6 0.098 13.1 0.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETO03806.1 - 0.069 11.9 1.8 0.11 11.2 1.8 1.4 1 0 0 1 1 1 0 Presenilin RPN2_C PF18004.1 ETO03806.1 - 0.31 11.0 9.0 0.14 12.1 6.9 1.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain O-antigen_lig PF13425.6 ETO03806.1 - 0.55 9.0 3.1 0.79 8.4 3.1 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Trypan_PARP PF05887.11 ETO03806.1 - 0.59 10.1 4.5 0.33 10.9 2.6 1.5 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF4820 PF16091.5 ETO03806.1 - 2.4 7.5 5.8 3.6 6.9 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Cytomega_UL84 PF06284.11 ETO03806.1 - 4.2 5.7 5.2 6.3 5.1 5.2 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Nop14 PF04147.12 ETO03806.1 - 6.4 4.9 14.6 9 4.4 14.6 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ETO03806.1 - 8.8 4.3 14.6 16 3.5 14.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi Thyroglob_assoc PF16597.5 ETO03808.1 - 0.21 11.9 1.8 0.43 10.9 0.7 2.2 2 1 0 2 2 2 0 Thyroglobulin_1 repeat associated disordered domain Kelch_1 PF01344.25 ETO03809.1 - 0.014 15.0 1.1 1.2 8.7 0.1 2.4 2 1 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO03809.1 - 0.094 12.7 0.1 7.6 6.6 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO03809.1 - 0.14 12.5 1.4 11 6.5 0.0 2.8 2 1 0 2 2 2 0 Kelch motif U79_P34 PF03064.16 ETO03810.1 - 0.11 11.8 15.5 0.14 11.5 15.5 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 RR_TM4-6 PF06459.12 ETO03810.1 - 2.3 8.0 13.5 2.6 7.8 13.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LMBR1 PF04791.16 ETO03810.1 - 4.5 6.1 6.8 5.2 5.9 6.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PH_12 PF16457.5 ETO03811.1 - 7.7e-11 42.7 0.1 9.9e-11 42.3 0.1 1.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_14 PF17787.1 ETO03811.1 - 9.6e-06 25.5 0.3 3.2e-05 23.8 0.3 1.7 1 1 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 ETO03811.1 - 0.016 15.3 0.1 0.019 15.0 0.1 1.1 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology STT3_PglB_C PF18527.1 ETO03811.1 - 0.071 13.2 0.3 0.24 11.5 0.2 1.9 2 1 0 2 2 2 0 STT3/PglB C-terminal beta-barrel domain DUF5362 PF17319.2 ETO03812.1 - 0.15 11.9 0.8 0.25 11.2 0.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5362) Annexin PF00191.20 ETO03813.1 - 1.1e-13 51.1 0.7 6.4e-08 32.6 0.0 2.9 3 0 0 3 3 3 2 Annexin Lycopene_cycl PF05834.12 ETO03814.1 - 0.069 12.2 0.1 0.085 11.9 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein DUF4604 PF15377.6 ETO03815.1 - 2.5 8.5 31.6 3 8.2 31.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) MMPL PF03176.15 ETO03816.1 - 1.8e-22 79.7 1.2 2.6e-22 79.2 1.2 1.1 1 0 0 1 1 1 1 MMPL family ACR_tran PF00873.19 ETO03816.1 - 0.16 9.6 1.5 0.18 9.4 1.5 1.0 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family TPR_12 PF13424.6 ETO03819.1 - 7.7e-59 195.9 6.0 5.1e-24 84.4 0.1 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03819.1 - 3.6e-37 125.2 0.0 1.1e-10 41.0 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03819.1 - 8.3e-25 85.5 19.4 4.3e-11 42.2 1.6 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO03819.1 - 4.2e-24 82.7 2.0 5.9e-10 38.5 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO03819.1 - 2.7e-21 73.9 19.7 8.4e-09 35.0 1.7 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03819.1 - 5.6e-20 69.8 13.6 8.3e-09 34.9 0.4 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO03819.1 - 1.1e-12 47.3 1.8 0.0027 18.0 0.0 4.0 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03819.1 - 8e-10 39.2 0.0 0.034 14.8 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat PPR PF01535.20 ETO03819.1 - 2.9e-07 30.3 1.9 0.016 15.5 0.1 3.4 3 0 0 3 3 3 2 PPR repeat DUF5113 PF17140.4 ETO03819.1 - 2.2e-06 27.5 7.6 0.078 12.8 0.3 3.1 1 1 2 3 3 3 3 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO03819.1 - 4.8e-06 26.4 10.5 0.006 16.6 0.3 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO03819.1 - 1.7e-05 25.3 0.0 0.039 14.8 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO03819.1 - 3.1e-05 23.5 20.8 0.0006 19.5 5.2 5.8 3 2 3 6 6 6 2 TPR repeat TPR_6 PF13174.6 ETO03819.1 - 7.4e-05 23.1 2.4 0.07 13.8 0.0 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO03819.1 - 0.00032 20.2 0.0 0.00043 19.8 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region SNAP PF14938.6 ETO03819.1 - 0.0014 18.1 3.1 0.0041 16.6 2.7 1.8 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP ANAPC3 PF12895.7 ETO03819.1 - 0.0015 18.8 5.4 0.62 10.3 0.9 2.6 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO03819.1 - 0.0015 17.9 0.7 0.19 11.2 0.1 3.2 3 0 0 3 3 3 1 SHNi-TPR RPN7 PF10602.9 ETO03819.1 - 0.0021 17.8 4.8 0.33 10.6 0.3 2.8 1 1 1 2 2 2 2 26S proteasome subunit RPN7 YecM PF06185.12 ETO03819.1 - 0.0023 17.6 0.3 3.6 7.2 0.0 3.1 2 1 1 3 3 3 1 YecM protein Vps39_1 PF10366.9 ETO03819.1 - 0.0042 17.4 3.3 7.4 6.9 0.2 3.2 1 1 2 3 3 3 0 Vacuolar sorting protein 39 domain 1 DUF2225 PF09986.9 ETO03819.1 - 0.0068 16.1 3.8 0.34 10.6 0.2 2.1 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 ETO03819.1 - 0.021 15.3 0.2 1.1 9.8 0.0 2.4 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF386 PF04074.12 ETO03819.1 - 0.022 14.6 2.2 0.036 14.0 2.2 1.4 1 1 0 1 1 1 0 YhcH/YjgK/YiaL FATC PF02260.20 ETO03819.1 - 0.024 14.5 0.1 1 9.2 0.0 2.5 3 0 0 3 3 3 0 FATC domain DUF4810 PF16068.5 ETO03819.1 - 0.028 15.0 2.1 0.37 11.4 0.4 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4810) DUF3856 PF12968.7 ETO03819.1 - 0.039 14.0 0.3 5 7.2 0.0 2.2 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) PPR_2 PF13041.6 ETO03819.1 - 0.14 12.3 3.4 11 6.4 0.1 3.0 3 0 0 3 3 3 0 PPR repeat family OrfA PF17495.2 ETO03819.1 - 0.16 12.1 0.0 11 6.3 0.0 2.3 1 1 2 3 3 3 0 Vpr-like OrfA DUF627 PF04781.12 ETO03819.1 - 0.26 11.3 4.7 8.3 6.5 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF627) MIT PF04212.18 ETO03819.1 - 0.28 11.3 13.7 0.3 11.2 0.9 3.6 3 1 1 4 4 3 0 MIT (microtubule interacting and transport) domain SLT PF01464.20 ETO03819.1 - 0.45 10.2 5.0 7.5 6.2 0.2 3.0 1 1 2 3 3 3 0 Transglycosylase SLT domain ATP-synt_E_2 PF08112.11 ETO03819.1 - 0.51 10.6 10.1 4.1 7.8 0.3 3.8 4 0 0 4 4 4 0 ATP synthase epsilon subunit Sel1 PF08238.12 ETO03819.1 - 0.62 10.8 13.5 6.4 7.6 0.3 5.1 4 2 0 4 4 4 0 Sel1 repeat NYN PF01936.18 ETO03820.1 - 7.8e-08 32.9 0.1 1e-07 32.5 0.1 1.1 1 0 0 1 1 1 1 NYN domain Radical_SAM PF04055.21 ETO03821.1 - 5.7e-19 69.1 0.0 9.1e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily Ribosom_S30AE_C PF16321.5 ETO03821.1 - 2.4e-14 52.8 0.1 4.1e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 Sigma 54 modulation/S30EA ribosomal protein C terminus Fer4_14 PF13394.6 ETO03821.1 - 0.00016 21.8 0.1 0.00037 20.6 0.1 1.5 1 0 0 1 1 1 1 4Fe-4S single cluster domain Fer4_12 PF13353.6 ETO03821.1 - 0.048 13.9 0.1 0.086 13.1 0.1 1.4 1 0 0 1 1 1 0 4Fe-4S single cluster domain Cation_efflux PF01545.21 ETO03822.1 - 2.7e-36 125.2 22.0 3.2e-36 125.0 22.0 1.1 1 0 0 1 1 1 1 Cation efflux family DUF3938 PF13074.6 ETO03822.1 - 7.8 6.8 8.6 3.5 7.9 2.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3938) CTP_transf_3 PF02348.19 ETO03823.1 - 1.4e-32 113.4 0.0 1.8e-32 113.1 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase NTP_transf_3 PF12804.7 ETO03823.1 - 5.6e-07 30.0 0.0 6.4e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 MobA-like NTP transferase domain CofC PF01983.16 ETO03823.1 - 0.024 13.8 1.3 0.11 11.7 0.4 2.0 2 0 0 2 2 2 0 Guanylyl transferase CofC like Phytase-like PF13449.6 ETO03824.1 - 1.1e-43 150.2 0.2 1.5e-43 149.8 0.2 1.2 1 0 0 1 1 1 1 Esterase-like activity of phytase SdiA-regulated PF06977.11 ETO03824.1 - 0.0088 15.3 0.0 0.02 14.1 0.0 1.6 1 0 0 1 1 1 1 SdiA-regulated NHL PF01436.21 ETO03824.1 - 0.11 12.6 0.0 2 8.6 0.0 2.8 2 0 0 2 2 2 0 NHL repeat WG_beta_rep PF14903.6 ETO03824.1 - 1.2 9.5 5.0 21 5.5 0.2 3.4 3 0 0 3 3 3 0 WG containing repeat DUF4805 PF16063.5 ETO03825.1 - 0.0097 15.3 7.8 0.013 14.8 7.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4805) SSP160 PF06933.11 ETO03825.1 - 0.011 14.0 8.3 0.015 13.6 8.3 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 tRNA_bind_3 PF17176.4 ETO03825.1 - 0.11 12.7 0.0 0.25 11.7 0.0 1.6 1 0 0 1 1 1 0 tRNA-binding domain DUF4187 PF13821.6 ETO03825.1 - 0.12 12.2 0.1 0.27 11.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) Mucin PF01456.17 ETO03825.1 - 2.3 8.2 24.8 0.15 12.0 17.1 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF5110 PF17137.4 ETO03826.1 - 2.7e-14 53.2 0.0 3.3e-14 52.9 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) RsgA_GTPase PF03193.16 ETO03827.1 - 5.6e-06 26.4 0.4 9.9e-05 22.3 0.4 2.3 1 1 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO03827.1 - 1.3e-05 25.2 0.0 3.8e-05 23.7 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO03827.1 - 0.0012 19.3 0.0 0.0023 18.4 0.0 1.5 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETO03827.1 - 0.0085 15.8 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Dynamin_N PF00350.23 ETO03827.1 - 0.029 14.4 1.9 0.79 9.8 0.0 2.5 2 1 1 3 3 3 0 Dynamin family Septin PF00735.18 ETO03827.1 - 0.034 13.4 0.3 0.062 12.6 0.0 1.5 2 0 0 2 2 2 0 Septin AAA_22 PF13401.6 ETO03827.1 - 0.035 14.4 0.0 0.43 10.9 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_7 PF12775.7 ETO03827.1 - 0.084 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_23 PF13476.6 ETO03827.1 - 0.12 12.8 1.7 0.14 12.6 1.7 1.6 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO03827.1 - 0.15 12.3 0.4 0.24 11.7 0.4 1.5 1 1 0 1 1 1 0 AAA domain T2SSE PF00437.20 ETO03827.1 - 0.18 10.8 0.1 0.31 10.1 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 ETO03827.1 - 0.19 11.4 0.1 0.31 10.7 0.1 1.4 1 1 0 1 1 1 0 IstB-like ATP binding protein DUF815 PF05673.13 ETO03827.1 - 0.2 10.8 0.0 0.47 9.6 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF815) Peptidase_S49_N PF08496.10 ETO03828.1 - 1.6 8.8 6.5 2.2 8.3 6.5 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Peptidase_M24 PF00557.24 ETO03829.1 - 3.8e-21 75.7 0.0 4.7e-21 75.4 0.0 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 SRP-alpha_N PF04086.13 ETO03830.1 - 6.6 6.6 23.6 7.3 6.4 23.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal VSG_B PF13206.6 ETO03832.1 - 0.0047 16.2 5.1 0.005 16.1 5.1 1.0 1 0 0 1 1 1 1 Trypanosomal VSG domain Rtf2 PF04641.12 ETO03832.1 - 0.011 15.1 8.1 0.013 14.9 8.1 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger WW PF00397.26 ETO03833.1 - 0.091 12.9 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 WW domain DUF2079 PF09852.9 ETO03834.1 - 0.005 15.7 2.3 0.0072 15.2 2.3 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2079) Ank_2 PF12796.7 ETO03834.1 - 0.0074 16.9 0.0 0.014 15.9 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF5436 PF17504.2 ETO03834.1 - 0.033 14.5 2.4 0.033 14.5 2.4 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5436) Ank_4 PF13637.6 ETO03834.1 - 0.058 14.0 0.1 0.13 12.9 0.1 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) BcsB PF03170.13 ETO03835.1 - 0.00048 18.6 0.3 0.00061 18.3 0.3 1.1 1 0 0 1 1 1 1 Bacterial cellulose synthase subunit F_actin_bind PF08919.10 ETO03835.1 - 0.0019 18.3 0.6 0.033 14.3 0.0 2.4 2 1 0 2 2 2 1 F-actin binding Mis14 PF08641.12 ETO03835.1 - 0.0062 16.8 2.7 0.0092 16.3 2.7 1.3 1 0 0 1 1 1 1 Kinetochore protein Mis14 like Syntaxin PF00804.25 ETO03835.1 - 0.021 14.5 3.3 0.03 14.0 3.3 1.2 1 0 0 1 1 1 0 Syntaxin DUF3449 PF11931.8 ETO03835.1 - 0.029 14.2 2.8 0.042 13.6 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) TMCO5 PF14992.6 ETO03835.1 - 0.038 13.6 3.4 0.052 13.1 3.4 1.1 1 0 0 1 1 1 0 TMCO5 family DUF1779 PF08680.10 ETO03835.1 - 0.06 13.5 4.0 0.086 13.0 4.0 1.2 1 0 0 1 1 1 0 TATA-box binding DivIVA PF05103.13 ETO03835.1 - 0.075 13.1 3.9 0.13 12.4 3.9 1.4 1 0 0 1 1 1 0 DivIVA protein HALZ PF02183.18 ETO03835.1 - 0.1 12.8 1.4 0.1 12.8 1.4 2.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper ABC_tran_Xtn PF12848.7 ETO03835.1 - 0.16 12.0 5.8 0.25 11.4 5.8 1.2 1 0 0 1 1 1 0 ABC transporter PRKG1_interact PF15898.5 ETO03835.1 - 0.16 12.9 6.0 0.31 11.9 6.0 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF1640 PF07798.11 ETO03835.1 - 0.22 11.6 7.6 0.46 10.5 6.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) YabA PF06156.13 ETO03835.1 - 6.9 7.4 7.3 20 5.9 7.4 1.7 2 1 0 2 2 1 0 Initiation control protein YabA SAM_1 PF00536.30 ETO03837.1 - 7.1e-22 77.6 0.0 9.3e-22 77.2 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO03837.1 - 5e-19 68.2 0.1 6.6e-19 67.8 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ETO03837.1 - 2.8e-07 30.4 0.0 3.8e-07 30.0 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO03837.1 - 5.1e-05 23.1 0.2 7.8e-05 22.6 0.2 1.3 1 1 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_Ste50p PF09235.10 ETO03837.1 - 0.099 12.9 0.1 0.21 11.8 0.1 1.6 1 1 0 1 1 1 0 Ste50p, sterile alpha motif DUF1387 PF07139.11 ETO03837.1 - 8.6 6.0 10.4 9.6 5.8 10.4 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1387) CAP_N PF01213.19 ETO03838.1 - 0.52 9.7 17.2 0.031 13.7 3.1 2.2 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal P3A PF08727.11 ETO03838.1 - 0.58 9.6 0.1 0.58 9.6 0.1 4.7 3 2 1 4 4 4 0 Poliovirus 3A protein like Golgin_A5 PF09787.9 ETO03839.1 - 1.5e-09 37.8 12.9 4.3e-05 23.1 3.4 2.1 2 0 0 2 2 2 2 Golgin subfamily A member 5 SHE3 PF17078.5 ETO03839.1 - 0.0094 15.7 3.6 0.014 15.1 3.6 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Trimer_CC PF08954.11 ETO03839.1 - 0.061 12.9 6.1 0.76 9.4 0.1 2.3 1 1 1 2 2 2 0 Trimerisation motif Spc7 PF08317.11 ETO03839.1 - 0.11 11.3 3.4 0.13 11.1 2.8 1.4 2 0 0 2 2 2 0 Spc7 kinetochore protein CASP_C PF08172.12 ETO03839.1 - 0.15 11.4 8.2 0.46 9.8 1.9 2.2 2 0 0 2 2 2 0 CASP C terminal DUF4527 PF15030.6 ETO03839.1 - 0.15 11.4 4.9 0.21 11.0 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) Mod_r PF07200.13 ETO03839.1 - 0.66 10.1 7.2 0.93 9.6 7.2 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Cep57_CLD_2 PF14197.6 ETO03839.1 - 1.6 8.9 6.8 2.6 8.2 6.8 1.3 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Cullin PF00888.22 ETO03840.1 - 2.2e-17 62.9 0.5 2.4e-17 62.8 0.5 1.0 1 0 0 1 1 1 1 Cullin family VF530 PF09905.9 ETO03840.1 - 0.0087 16.2 0.2 0.02 15.1 0.0 1.7 2 0 0 2 2 2 1 DNA-binding protein VF530 DUF4834 PF16118.5 ETO03841.1 - 1.5 9.8 5.1 2.1 9.4 1.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PASTA PF03793.19 ETO03842.1 - 0.43 10.5 0.1 0.43 10.5 0.1 2.4 3 1 1 4 4 4 0 PASTA domain GAS PF13851.6 ETO03843.1 - 0.015 14.7 26.1 0.82 9.0 17.2 3.0 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Laminin_II PF06009.12 ETO03843.1 - 0.016 15.3 11.9 0.038 14.0 3.5 2.3 1 1 1 2 2 2 0 Laminin Domain II DUF916 PF06030.12 ETO03843.1 - 0.016 15.3 0.8 0.016 15.3 0.8 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF916) AstB PF04996.12 ETO03843.1 - 0.017 13.8 1.9 0.022 13.4 1.9 1.1 1 0 0 1 1 1 0 Succinylarginine dihydrolase BST2 PF16716.5 ETO03843.1 - 0.065 13.8 5.8 0.065 13.8 5.8 3.3 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 IL2 PF00715.17 ETO03843.1 - 0.08 12.9 8.4 0.021 14.8 3.4 2.0 1 1 1 2 2 2 0 Interleukin 2 Myc-LZ PF02344.15 ETO03843.1 - 0.14 12.3 3.6 0.28 11.3 0.0 3.2 3 0 0 3 3 3 0 Myc leucine zipper domain Tweety PF04906.13 ETO03843.1 - 0.16 10.6 2.5 0.17 10.5 2.0 1.3 1 1 0 1 1 1 0 Tweety STAT_alpha PF01017.20 ETO03843.1 - 0.19 11.6 15.7 0.91 9.4 11.3 2.8 1 1 1 2 2 2 0 STAT protein, all-alpha domain DUF1947 PF09183.10 ETO03843.1 - 0.23 11.8 0.1 0.23 11.8 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1947) SlyX PF04102.12 ETO03843.1 - 0.29 11.8 14.8 0.57 10.8 0.9 3.5 2 1 1 3 3 3 0 SlyX DUF2922 PF11148.8 ETO03843.1 - 0.31 10.8 4.4 0.66 9.7 1.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2922) TPR_MLP1_2 PF07926.12 ETO03843.1 - 0.33 11.0 15.6 0.45 10.6 3.3 2.5 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DNA_pol3_beta_3 PF02768.15 ETO03843.1 - 0.41 10.5 6.6 0.24 11.3 1.4 2.4 2 1 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain Exonuc_VII_L PF02601.15 ETO03843.1 - 0.63 9.6 9.1 1.1 8.7 9.1 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit Baculo_PEP_C PF04513.12 ETO03843.1 - 0.71 9.9 5.1 0.63 10.1 2.4 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CHDCT2 PF08074.11 ETO03843.1 - 0.73 10.0 5.6 0.9 9.7 5.2 1.4 1 1 0 1 1 1 0 CHDCT2 (NUC038) domain Tropomyosin_1 PF12718.7 ETO03843.1 - 0.8 9.9 22.8 2.1 8.5 6.1 2.3 2 0 0 2 2 2 0 Tropomyosin like Prominin PF05478.11 ETO03843.1 - 0.98 7.3 10.0 1.3 6.9 10.0 1.1 1 0 0 1 1 1 0 Prominin HMMR_N PF15905.5 ETO03843.1 - 1.1 8.6 21.9 1.9 7.9 21.9 1.5 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal HIP1_clath_bdg PF16515.5 ETO03843.1 - 1.6 9.4 22.1 6.7 7.4 4.8 3.0 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ERM PF00769.19 ETO03843.1 - 4.1 7.1 19.4 6.5 6.5 14.3 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family LMBR1 PF04791.16 ETO03843.1 - 5.2 5.9 7.1 6.3 5.6 7.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF641 PF04859.12 ETO03843.1 - 5.9 7.2 19.2 1.5 9.1 1.7 3.1 1 1 1 3 3 3 0 Plant protein of unknown function (DUF641) NYD-SP28 PF14772.6 ETO03843.1 - 6.3 6.9 21.1 0.93 9.6 10.0 3.4 2 1 0 2 2 2 0 Sperm tail Ion_trans PF00520.31 ETO03844.1 - 4.8e-22 78.4 11.9 6.1e-22 78.0 11.9 1.1 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ETO03844.1 - 1.6e-11 44.0 2.2 1.6e-11 44.0 2.2 2.2 1 1 1 2 2 2 1 Ion channel CHAT PF12770.7 ETO03845.1 - 4.4e-11 42.7 0.3 5.4e-11 42.4 0.3 1.1 1 0 0 1 1 1 1 CHAT domain Peptidase_C25 PF01364.18 ETO03845.1 - 0.032 13.4 0.0 0.037 13.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase family C25 DUF1002 PF06207.11 ETO03845.1 - 0.12 11.8 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) ParBc_2 PF08857.11 ETO03846.1 - 1.9e-32 112.6 5.3 8.8e-28 97.4 0.4 2.1 1 1 1 2 2 2 2 Putative ParB-like nuclease Ferrochelatase PF00762.19 ETO03847.1 - 1.5e-48 165.6 0.0 1.6e-48 165.4 0.0 1.0 1 0 0 1 1 1 1 Ferrochelatase Ferric_reduct PF01794.19 ETO03850.1 - 0.0002 21.5 4.5 0.0002 21.5 4.5 2.4 1 1 1 2 2 2 1 Ferric reductase like transmembrane component PerB PF06590.11 ETO03850.1 - 0.082 13.4 0.3 0.12 12.9 0.3 1.3 1 0 0 1 1 1 0 PerB protein SNARE_assoc PF09335.11 ETO03850.1 - 0.082 13.4 4.0 1 9.9 0.3 2.1 1 1 1 2 2 2 0 SNARE associated Golgi protein DUF4064 PF13273.6 ETO03850.1 - 0.09 13.1 3.0 0.89 9.9 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Cation_ATPase_C PF00689.21 ETO03850.1 - 0.14 11.9 8.4 0.27 10.9 3.5 2.2 2 1 0 2 2 2 0 Cation transporting ATPase, C-terminus Pho86 PF11124.8 ETO03850.1 - 0.17 11.3 6.4 2.2 7.7 0.2 2.0 1 1 1 2 2 2 0 Inorganic phosphate transporter Pho86 E1-E2_ATPase PF00122.20 ETO03850.1 - 0.41 10.1 7.2 0.048 13.2 2.0 1.8 1 1 1 2 2 2 0 E1-E2 ATPase DUF4405 PF14358.6 ETO03850.1 - 0.75 10.4 9.5 0.094 13.3 4.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4405) GWT1 PF06423.12 ETO03850.1 - 1.6 8.9 6.1 23 5.1 3.4 2.1 1 1 1 2 2 2 0 GWT1 Ion_trans PF00520.31 ETO03851.1 - 0.0077 15.5 1.3 0.011 15.0 1.3 1.2 1 0 0 1 1 1 1 Ion transport protein E7 PF00527.18 ETO03851.1 - 0.065 13.4 0.9 0.12 12.6 0.9 1.5 1 1 0 1 1 1 0 E7 protein, Early protein RNase_PH PF01138.21 ETO03852.1 - 0.00043 20.8 0.0 0.00089 19.8 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Amino_oxidase PF01593.24 ETO03854.1 - 0.0011 18.4 0.1 0.0015 17.9 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase RhoGEF PF00621.20 ETO03860.1 - 5.8e-07 29.9 0.1 1.1e-06 29.0 0.1 1.5 1 0 0 1 1 1 1 RhoGEF domain Flavodoxin_1 PF00258.25 ETO03861.1 - 4.8e-22 78.7 0.1 6.3e-22 78.3 0.1 1.1 1 0 0 1 1 1 1 Flavodoxin DUF3464 PF11947.8 ETO03862.1 - 0.16 11.7 1.3 0.24 11.1 1.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Mit_KHE1 PF10173.9 ETO03862.1 - 0.95 9.5 4.1 1 9.4 4.1 1.3 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Pkinase PF00069.25 ETO03863.1 - 9.9e-22 77.5 0.0 1.1e-21 77.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03863.1 - 1.5e-10 40.9 0.0 1.7e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO03863.1 - 0.0035 16.7 0.0 0.0043 16.4 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO03863.1 - 0.0051 15.6 0.0 0.0058 15.4 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO03863.1 - 0.1 12.5 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family COX7a PF02238.15 ETO03865.1 - 0.15 12.4 0.3 0.28 11.6 0.3 1.4 1 0 0 1 1 1 0 Cytochrome c oxidase subunit VII Pkinase PF00069.25 ETO03866.1 - 3.8e-35 121.5 0.0 4.2e-35 121.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03866.1 - 4.6e-19 68.7 0.0 5e-19 68.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO03866.1 - 0.016 14.5 0.0 0.018 14.3 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Pkinase_fungal PF17667.1 ETO03866.1 - 0.026 13.3 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Haspin_kinase PF12330.8 ETO03866.1 - 0.16 10.9 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Adaptin_N PF01602.20 ETO03868.1 - 8e-39 133.6 0.1 9.6e-39 133.3 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO03868.1 - 1.4e-15 57.7 0.0 1.7e-15 57.4 0.0 1.0 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO03868.1 - 2.6e-05 24.5 0.0 0.0069 16.8 0.0 2.2 1 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO03868.1 - 3.6e-05 23.7 2.4 2.4 8.6 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat RTP1_C1 PF10363.9 ETO03868.1 - 0.0039 17.4 0.0 0.0074 16.5 0.0 1.6 1 1 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 API5 PF05918.11 ETO03868.1 - 0.013 14.4 0.0 0.015 14.2 0.0 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) HEAT_UF PF18817.1 ETO03868.1 - 0.02 15.2 0.0 0.099 12.9 0.0 2.2 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 HEAT_EZ PF13513.6 ETO03868.1 - 0.072 13.6 0.1 6.2 7.4 0.1 2.9 2 1 0 2 2 2 0 HEAT-like repeat Hamartin PF04388.12 ETO03868.1 - 0.084 11.5 0.2 0.11 11.2 0.2 1.1 1 0 0 1 1 1 0 Hamartin protein RRM_1 PF00076.22 ETO03870.1 - 0.00018 21.3 0.1 0.0004 20.1 0.1 1.8 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO03870.1 - 0.06 13.4 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4825 PF16107.5 ETO03870.1 - 0.079 13.1 0.0 0.079 13.1 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4825) Spore_III_AF PF09581.10 ETO03870.1 - 0.12 12.4 2.1 0.13 12.2 2.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF4028 PF13220.6 ETO03871.1 - 0.0093 15.7 0.9 0.02 14.6 0.2 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF4028) Anticodon_1 PF08264.13 ETO03872.1 - 9.3e-06 25.7 0.0 1.2e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA_bind PF01588.20 ETO03872.1 - 3.1e-05 24.0 0.0 6.1e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain AAA_23 PF13476.6 ETO03873.1 - 0.14 12.6 7.1 0.17 12.4 7.1 1.1 1 0 0 1 1 1 0 AAA domain PEHE PF15275.6 ETO03874.1 - 0.067 13.8 0.3 0.077 13.6 0.3 1.1 1 0 0 1 1 1 0 PEHE domain FlxA PF14282.6 ETO03874.1 - 0.099 12.6 8.7 0.12 12.4 8.7 1.2 1 0 0 1 1 1 0 FlxA-like protein DUF2205 PF10224.9 ETO03874.1 - 0.11 12.5 2.5 0.16 12.0 2.5 1.2 1 0 0 1 1 1 0 Short coiled-coil protein HEAT_2 PF13646.6 ETO03875.1 - 0.00014 22.2 0.0 0.00021 21.6 0.0 1.2 1 0 0 1 1 1 1 HEAT repeats Cnd1 PF12717.7 ETO03875.1 - 0.0016 18.5 1.8 0.0028 17.7 1.4 1.5 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO03875.1 - 0.0043 17.6 0.4 0.01 16.4 0.3 1.6 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ETO03875.1 - 0.026 13.1 1.6 0.027 13.0 0.4 1.6 1 1 0 1 1 1 0 Adaptin N terminal region DUF3381 PF11861.8 ETO03876.1 - 7.4e-29 100.7 8.4 1e-28 100.2 8.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3381) PVL_ORF50 PF07768.11 ETO03876.1 - 0.021 15.1 3.3 0.021 15.1 3.3 2.1 2 0 0 2 2 2 0 PVL ORF-50-like family AP-5_subunit_s1 PF15001.6 ETO03876.1 - 0.079 12.9 1.1 0.1 12.6 0.2 1.6 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 Phage_holin_6_1 PF09682.10 ETO03876.1 - 0.15 12.5 3.7 1 9.8 0.9 2.1 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) RasGEF PF00617.19 ETO03878.1 - 0.00014 22.1 0.0 0.00022 21.5 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain U79_P34 PF03064.16 ETO03878.1 - 0.028 13.8 2.3 0.036 13.4 2.3 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 OATP PF03137.20 ETO03878.1 - 0.31 9.3 0.2 0.39 8.9 0.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Adaptin_N PF01602.20 ETO03879.1 - 8.4e-24 84.0 0.2 9.3e-24 83.9 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region CtsR_C PF17727.1 ETO03879.1 - 0.0034 17.5 1.4 1 9.5 0.1 2.4 2 0 0 2 2 2 2 CtsR C-terminal dimerization domain HEAT PF02985.22 ETO03879.1 - 0.012 15.8 0.2 1.1 9.6 0.1 3.3 3 0 0 3 3 3 0 HEAT repeat MIF4G PF02854.19 ETO03879.1 - 0.057 13.1 0.1 0.068 12.8 0.1 1.1 1 0 0 1 1 1 0 MIF4G domain YvbH_ext PF11724.8 ETO03880.1 - 0.44 10.9 4.5 0.79 10.1 0.2 2.7 2 2 1 3 3 3 0 YvbH-like oligomerisation region DUF2660 PF10859.8 ETO03880.1 - 0.95 10.0 7.8 5.3 7.6 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2660) META PF03724.16 ETO03882.1 - 0.032 14.2 1.0 0.05 13.6 1.0 1.3 1 0 0 1 1 1 0 META domain CENP-H PF05837.12 ETO03882.1 - 3.4 8.1 9.8 1.7 9.1 7.7 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) YabA PF06156.13 ETO03882.1 - 7.4 7.3 11.8 0.35 11.5 3.8 2.2 1 1 1 2 2 2 0 Initiation control protein YabA TCP PF03634.13 ETO03883.1 - 2.4 8.7 15.4 3.2 8.3 15.4 1.1 1 0 0 1 1 1 0 TCP family transcription factor eIF-3_zeta PF05091.12 ETO03883.1 - 2.5 7.0 15.7 2.6 6.9 15.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 ETO03883.1 - 2.7 7.8 23.4 2.8 7.7 23.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spore_coat_CotO PF14153.6 ETO03883.1 - 3 7.7 25.0 4.3 7.2 25.0 1.3 1 0 0 1 1 1 0 Spore coat protein CotO EOS1 PF12326.8 ETO03883.1 - 3.1 7.7 4.1 4 7.3 4.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein DUF913 PF06025.12 ETO03883.1 - 3.4 6.6 12.3 4.1 6.3 12.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 ETO03883.1 - 3.9 7.6 13.9 4.5 7.4 13.9 1.1 1 0 0 1 1 1 0 DDHD domain DUF3043 PF11241.8 ETO03883.1 - 7.7 6.5 7.7 9.2 6.3 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) V_ATPase_I PF01496.19 ETO03883.1 - 7.9 4.3 13.1 8.2 4.2 13.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 ETO03883.1 - 9.4 6.2 12.9 10 6.1 12.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region zf-MIZ PF02891.20 ETO03884.1 - 4.5e-19 67.9 6.2 4.5e-19 67.9 6.2 3.1 3 1 0 3 3 3 1 MIZ/SP-RING zinc finger zf-MYND PF01753.18 ETO03884.1 - 5.7e-11 42.3 7.9 5.7e-11 42.3 7.9 2.5 2 0 0 2 2 2 1 MYND finger zf-Nse PF11789.8 ETO03884.1 - 2.3e-05 24.1 2.5 8.6e-05 22.3 2.5 2.1 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-TFIIB PF13453.6 ETO03884.1 - 0.3 10.4 5.6 2.3 7.6 0.4 2.7 2 0 0 2 2 2 0 Transcription factor zinc-finger zf-Sec23_Sec24 PF04810.15 ETO03884.1 - 0.82 9.8 0.1 0.82 9.8 0.1 3.6 2 1 1 3 3 3 0 Sec23/Sec24 zinc finger zf-RanBP PF00641.18 ETO03884.1 - 3.9 6.9 12.4 0.26 10.6 0.8 3.8 3 1 0 3 3 3 0 Zn-finger in Ran binding protein and others dDENN PF03455.19 ETO03885.1 - 2.2e-09 37.1 1.9 3.6e-09 36.5 1.9 1.3 1 0 0 1 1 1 1 dDENN domain SHE3 PF17078.5 ETO03886.1 - 0.0023 17.7 5.6 0.0023 17.7 5.6 1.8 1 1 0 1 1 1 1 SWI5-dependent HO expression protein 3 DUF3584 PF12128.8 ETO03886.1 - 0.004 14.7 13.7 0.0045 14.6 13.7 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Syntaxin_2 PF14523.6 ETO03886.1 - 0.0088 16.4 5.0 0.0088 16.4 5.0 2.2 1 1 1 2 2 2 1 Syntaxin-like protein AAA_32 PF13654.6 ETO03886.1 - 0.13 11.1 11.7 0.2 10.4 11.7 1.3 1 1 0 1 1 1 0 AAA domain DUF948 PF06103.11 ETO03886.1 - 0.14 12.4 3.5 3 8.2 1.1 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DegS PF05384.11 ETO03886.1 - 0.15 11.6 20.4 0.32 10.5 20.3 1.5 1 1 0 1 1 1 0 Sensor protein DegS Rootletin PF15035.6 ETO03886.1 - 0.17 11.9 18.7 0.028 14.5 9.5 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Seryl_tRNA_N PF02403.22 ETO03886.1 - 0.2 11.9 14.2 2.8 8.2 3.0 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FUSC PF04632.12 ETO03886.1 - 0.23 9.9 5.5 0.32 9.5 5.5 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family Mod_r PF07200.13 ETO03886.1 - 0.24 11.5 19.8 1 9.5 8.1 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein HAUS2 PF15003.6 ETO03886.1 - 0.25 11.1 8.4 0.18 11.5 6.4 1.6 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 2 DNA_pol_alpha_N PF12254.8 ETO03886.1 - 0.27 11.4 4.6 0.73 9.9 4.6 1.8 1 1 0 1 1 1 0 DNA polymerase alpha subunit p180 N terminal Prefoldin_2 PF01920.20 ETO03886.1 - 0.28 11.1 15.7 3 7.8 15.3 2.5 1 1 0 1 1 1 0 Prefoldin subunit DUF4200 PF13863.6 ETO03886.1 - 0.55 10.6 18.6 0.82 10.1 18.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF445 PF04286.12 ETO03886.1 - 0.99 9.1 8.3 1.2 8.9 8.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) THOC7 PF05615.13 ETO03886.1 - 1.6 9.0 21.7 5.6 7.3 5.5 2.1 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4446 PF14584.6 ETO03886.1 - 1.7 8.6 11.3 2.9 7.9 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DXP_reductoisom PF02670.16 ETO03886.1 - 1.7 9.3 4.3 4.7 7.9 1.3 2.0 1 1 0 2 2 2 0 1-deoxy-D-xylulose 5-phosphate reductoisomerase UPF0242 PF06785.11 ETO03886.1 - 1.8 8.6 16.0 2.5 8.2 16.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 ETO03886.1 - 1.9 7.8 12.0 2.6 7.3 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 ETO03886.1 - 2.1 8.4 7.2 7.9 6.5 6.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) KLRAQ PF10205.9 ETO03886.1 - 2.2 8.6 15.4 0.16 12.2 4.1 2.3 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein TPR_MLP1_2 PF07926.12 ETO03886.1 - 2.4 8.2 25.4 0.36 10.9 5.6 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein MbeD_MobD PF04899.12 ETO03886.1 - 2.5 8.3 11.6 1.5 9.0 6.3 2.6 1 1 1 2 2 2 0 MbeD/MobD like V_ATPase_I PF01496.19 ETO03886.1 - 2.7 5.8 9.8 3.3 5.5 9.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF724 PF05266.14 ETO03886.1 - 2.9 7.7 13.0 0.34 10.7 7.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF724) YtxH PF12732.7 ETO03886.1 - 2.9 8.5 4.7 12 6.5 4.7 2.1 1 1 0 1 1 1 0 YtxH-like protein Prominin PF05478.11 ETO03886.1 - 3.7 5.4 7.1 5.2 4.9 7.1 1.3 1 0 0 1 1 1 0 Prominin bZIP_2 PF07716.15 ETO03886.1 - 3.7 7.7 18.5 0.39 10.8 2.5 3.0 3 0 0 3 3 2 0 Basic region leucine zipper FapA PF03961.13 ETO03886.1 - 4.9 5.7 12.8 11 4.5 12.8 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A UPF0449 PF15136.6 ETO03886.1 - 5.4 7.5 13.8 4 8.0 4.0 2.3 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 zf-C4H2 PF10146.9 ETO03886.1 - 6.3 7.0 10.2 17 5.6 10.2 1.7 1 1 0 1 1 1 0 Zinc finger-containing protein Fib_alpha PF08702.10 ETO03886.1 - 7.2 6.8 15.1 4.9 7.3 11.8 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SWIRM-assoc_2 PF16496.5 ETO03887.1 - 0.0075 15.2 9.3 0.01 14.8 9.3 1.1 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal ORC6 PF05460.13 ETO03887.1 - 0.082 12.2 3.5 0.093 12.0 3.5 1.0 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) F-protein PF00469.20 ETO03887.1 - 1.3 8.5 3.7 0.66 9.5 0.7 1.7 1 1 1 2 2 2 0 Negative factor, (F-Protein) or Nef PHM7_cyt PF14703.6 ETO03888.1 - 3.3e-08 34.0 0.0 4.3e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter RSN1_7TM PF02714.15 ETO03888.1 - 0.0012 18.2 1.2 0.0012 18.2 1.2 1.5 2 0 0 2 2 2 1 Calcium-dependent channel, 7TM region, putative phosphate Bd3614-deam PF14439.6 ETO03888.1 - 0.0015 18.6 0.8 0.002 18.2 0.8 1.2 1 0 0 1 1 1 1 Bd3614-like deaminase Amnionless PF14828.6 ETO03888.1 - 0.0078 15.1 0.2 0.013 14.3 0.2 1.3 1 0 0 1 1 1 1 Amnionless zinc_ribbon_13 PF09855.9 ETO03890.1 - 0.0062 16.7 0.1 0.014 15.5 0.0 1.8 2 0 0 2 2 2 1 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) ArfGap PF01412.18 ETO03891.1 - 5.1e-32 110.4 2.4 1.1e-31 109.3 2.4 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Hep_59 PF07052.11 ETO03891.1 - 2.1 9.2 8.0 0.54 11.0 4.1 1.9 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 Holin_2-3 PF13272.6 ETO03892.1 - 0.23 11.8 2.6 0.33 11.3 2.6 1.2 1 0 0 1 1 1 0 Putative 2/3 transmembrane domain holin DUF2593 PF10767.9 ETO03892.1 - 2 8.5 13.0 0.23 11.5 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2593) DUF1387 PF07139.11 ETO03893.1 - 1.8 8.2 10.3 1.9 8.1 10.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Macoilin PF09726.9 ETO03893.1 - 8.9 4.7 9.6 10 4.6 9.6 1.0 1 0 0 1 1 1 0 Macoilin family Pyr_redox_2 PF07992.14 ETO03894.1 - 0.018 14.3 0.0 0.02 14.1 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase MutS_III PF05192.18 ETO03895.1 - 2.1e-12 47.7 0.1 2.7e-12 47.3 0.1 1.1 1 0 0 1 1 1 1 MutS domain III ABC2_membrane PF01061.24 ETO03896.1 - 9.6e-10 38.2 4.2 1.1e-09 38.0 4.2 1.0 1 0 0 1 1 1 1 ABC-2 type transporter SAM_2 PF07647.17 ETO03897.1 - 3.7e-08 33.4 0.1 5.5e-08 32.8 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) HyaE PF07449.11 ETO03897.1 - 0.033 14.1 0.0 0.045 13.7 0.0 1.2 1 0 0 1 1 1 0 Hydrogenase-1 expression protein HyaE Peptidase_C5 PF00770.18 ETO03897.1 - 0.43 10.2 3.0 3 7.5 1.3 2.1 1 1 0 2 2 2 0 Adenovirus endoprotease Mannosyl_trans3 PF11051.8 ETO03898.1 - 2.5e-06 27.1 0.3 3.2e-06 26.7 0.3 1.3 1 1 0 1 1 1 1 Mannosyltransferase putative DUF3284 PF11687.8 ETO03898.1 - 0.088 12.7 2.4 0.13 12.1 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3284) SAM_1 PF00536.30 ETO03900.1 - 3.7e-06 27.3 0.1 6.9e-06 26.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO03900.1 - 0.01 15.9 0.0 0.018 15.2 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Vps8 PF12816.7 ETO03901.1 - 0.03 13.8 0.2 0.037 13.5 0.2 1.1 1 0 0 1 1 1 0 Golgi CORVET complex core vacuolar protein 8 Peroxin-13_N PF04088.13 ETO03901.1 - 0.067 13.5 0.0 0.083 13.2 0.0 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region PARP PF00644.20 ETO03903.1 - 8.2e-08 32.1 0.1 9.4e-08 31.9 0.1 1.2 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DDE_Tnp_IS66 PF03050.14 ETO03904.1 - 1.7e-74 250.8 0.1 3.2e-74 249.9 0.0 1.4 2 0 0 2 2 2 1 Transposase IS66 family zf-IS66 PF13005.7 ETO03904.1 - 3.2e-11 43.4 3.0 7.8e-11 42.2 3.0 1.7 1 0 0 1 1 1 1 zinc-finger binding domain of transposase IS66 LZ_Tnp_IS66 PF13007.7 ETO03904.1 - 5.7e-07 30.2 0.4 1.3e-06 29.1 0.4 1.6 1 0 0 1 1 1 1 Transposase C of IS166 homeodomain HAP1_N PF04849.13 ETO03904.1 - 0.023 13.9 1.4 0.034 13.4 1.4 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region Maf1 PF09174.10 ETO03904.1 - 0.041 14.0 0.3 0.16 12.1 0.0 2.0 2 0 0 2 2 2 0 Maf1 regulator TMF_TATA_bd PF12325.8 ETO03904.1 - 0.095 12.9 2.3 0.17 12.1 2.3 1.3 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF5394 PF17372.2 ETO03904.1 - 0.15 11.6 1.9 0.23 11.0 1.9 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5394) Nup54 PF13874.6 ETO03904.1 - 0.16 12.1 2.5 0.25 11.5 2.5 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 DUF5304 PF17230.2 ETO03904.1 - 0.17 12.1 0.1 0.27 11.5 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5304) ZapB PF06005.12 ETO03904.1 - 0.18 12.3 5.0 0.35 11.3 5.0 1.4 1 0 0 1 1 1 0 Cell division protein ZapB GIT_CC PF16559.5 ETO03904.1 - 2.3 8.2 11.0 2.4 8.1 5.8 2.3 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor NRho PF16733.5 ETO03905.1 - 0.16 12.1 0.4 2.8 8.1 0.0 2.3 2 0 0 2 2 2 0 Rhomboid N-terminal domain Exostosin PF03016.15 ETO03906.1 - 0.0007 18.9 0.1 0.0024 17.1 0.0 1.9 1 1 1 2 2 2 1 Exostosin family SHR-BD PF06650.12 ETO03907.1 - 0.0021 17.5 0.0 0.0022 17.4 0.0 1.4 1 1 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 PCEMA1 PF07418.11 ETO03908.1 - 0.0067 16.0 0.6 0.0069 16.0 0.6 1.2 1 0 0 1 1 1 1 Acidic phosphoprotein precursor PCEMA1 Pkinase PF00069.25 ETO03909.1 - 8.3e-23 81.1 0.0 1e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03909.1 - 1e-07 31.5 0.0 1.3e-07 31.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase XK-related PF09815.9 ETO03910.1 - 4.8e-09 35.7 4.5 5.4e-09 35.6 4.5 1.0 1 0 0 1 1 1 1 XK-related protein tRNA-synt_2b PF00587.25 ETO03912.1 - 1e-16 61.5 0.0 1.1e-16 61.3 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) DUF4943 PF16301.5 ETO03912.1 - 0.0093 16.0 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4943) RPN2_C PF18004.1 ETO03913.1 - 1.2e-05 25.3 9.7 1.6e-05 24.9 9.7 1.1 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain NPR3 PF03666.13 ETO03913.1 - 0.019 13.8 6.9 0.021 13.7 6.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 ETO03913.1 - 0.02 13.7 4.4 0.022 13.6 4.4 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Phage_Gp23 PF10669.9 ETO03913.1 - 0.077 13.3 6.9 0.13 12.6 6.9 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF913 PF06025.12 ETO03913.1 - 0.12 11.3 5.4 0.14 11.1 5.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 ETO03913.1 - 0.21 11.3 1.8 0.26 11.0 1.8 1.3 1 0 0 1 1 1 0 Connexin RP-C_C PF11800.8 ETO03913.1 - 0.58 10.2 5.8 0.72 9.9 5.8 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region CSG2 PF16965.5 ETO03913.1 - 0.66 8.9 2.5 0.75 8.7 2.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 ETO03913.1 - 0.74 9.0 7.4 0.84 8.8 7.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETO03913.1 - 0.85 8.9 12.3 1.2 8.4 12.3 1.1 1 0 0 1 1 1 0 NOA36 protein SLC12 PF03522.15 ETO03913.1 - 1.3 8.0 8.0 1.5 7.8 8.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CCDC106 PF15794.5 ETO03913.1 - 1.4 8.6 11.4 2 8.1 11.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 PPP4R2 PF09184.11 ETO03913.1 - 2.1 7.8 18.1 3 7.4 18.1 1.1 1 0 0 1 1 1 0 PPP4R2 Presenilin PF01080.17 ETO03913.1 - 2.2 6.9 10.1 2.4 6.8 10.1 1.1 1 0 0 1 1 1 0 Presenilin TMEM214 PF10151.9 ETO03913.1 - 2.2 6.6 7.9 2.6 6.4 7.9 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Ferlin_C PF16165.5 ETO03913.1 - 2.7 7.9 5.7 4.7 7.1 5.7 1.4 1 0 0 1 1 1 0 Ferlin C-terminus Cytomega_UL84 PF06284.11 ETO03913.1 - 3.1 6.2 5.6 3.6 5.9 5.6 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Sec62 PF03839.16 ETO03913.1 - 4.5 6.7 6.8 5.6 6.4 6.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 PPL5 PF18168.1 ETO03913.1 - 8.9 5.5 10.9 6.9 5.9 9.7 1.3 1 1 0 1 1 1 0 Prim-pol family 5 LRR_4 PF12799.7 ETO03914.1 - 1.7e-07 31.4 5.6 0.0052 17.2 1.4 2.6 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ETO03914.1 - 0.00024 20.7 0.4 0.00059 19.4 0.4 1.6 1 1 1 2 2 2 1 Leucine-rich repeat LRR_8 PF13855.6 ETO03914.1 - 0.0023 17.7 3.5 0.19 11.5 0.2 2.7 1 1 2 3 3 3 3 Leucine rich repeat DLIC PF05783.11 ETO03915.1 - 5.4e-11 42.0 0.0 6.4e-11 41.7 0.0 1.0 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Arf PF00025.21 ETO03915.1 - 0.01 15.3 0.0 0.014 14.8 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO03915.1 - 0.13 11.8 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF2508 PF10704.9 ETO03916.1 - 0.054 13.7 9.0 0.054 13.7 9.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2508) Fumerase_C PF05683.12 ETO03916.1 - 0.06 12.7 0.1 0.078 12.3 0.1 1.2 1 0 0 1 1 1 0 Fumarase C-terminus Chordopox_A33R PF05966.12 ETO03917.1 - 0.018 14.3 0.1 0.024 13.9 0.1 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein Mg_trans_NIPA PF05653.14 ETO03917.1 - 0.089 11.9 0.1 0.12 11.5 0.1 1.1 1 0 0 1 1 1 0 Magnesium transporter NIPA DUF1676 PF07898.13 ETO03917.1 - 0.73 9.8 3.6 1.3 9.1 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) ORC6 PF05460.13 ETO03918.1 - 0.062 12.6 2.7 0.065 12.5 2.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) TFB6 PF17110.5 ETO03918.1 - 0.066 13.0 5.4 0.078 12.7 5.4 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH STAC2_u1 PF16664.5 ETO03918.1 - 0.09 13.2 2.9 0.29 11.6 2.9 1.8 1 1 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 BicD PF09730.9 ETO03918.1 - 0.12 10.8 6.3 0.13 10.6 6.3 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D DNA_pol_phi PF04931.13 ETO03918.1 - 0.17 9.9 14.8 0.19 9.8 14.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 ETO03918.1 - 0.23 11.3 9.0 0.27 11.0 9.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RXT2_N PF08595.11 ETO03918.1 - 0.81 9.7 8.6 1.1 9.3 8.6 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal RRN3 PF05327.11 ETO03918.1 - 1.2 7.6 8.0 1.2 7.6 8.0 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2722 PF10846.8 ETO03918.1 - 2.7 6.9 11.8 3.5 6.5 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Nop14 PF04147.12 ETO03918.1 - 3 5.9 12.3 3 6.0 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO03918.1 - 3.1 7.1 14.5 3.4 7.0 14.5 1.1 1 0 0 1 1 1 0 SDA1 G-alpha PF00503.20 ETO03919.1 - 5.1e-31 108.1 4.7 5.7e-31 108.0 4.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO03919.1 - 0.0019 17.7 0.1 0.0034 16.9 0.1 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Wbp11 PF09429.10 ETO03919.1 - 0.037 14.4 13.5 0.072 13.5 13.5 1.5 1 0 0 1 1 1 0 WW domain binding protein 11 CENP-O PF09496.10 ETO03920.1 - 0.0092 16.0 0.3 0.012 15.6 0.3 1.2 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component DUF5407 PF17401.2 ETO03920.1 - 0.019 15.2 0.3 0.044 14.0 0.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5407) AAA_23 PF13476.6 ETO03920.1 - 0.033 14.7 2.8 0.033 14.7 2.8 1.7 2 0 0 2 2 2 0 AAA domain DUF3736 PF12540.8 ETO03921.1 - 0.15 12.1 0.1 5.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3736) EB1_binding PF05937.11 ETO03922.1 - 0.039 14.6 2.8 0.045 14.4 2.8 1.0 1 0 0 1 1 1 0 EB-1 Binding Domain DUF4158 PF13700.6 ETO03923.1 - 1e-23 84.0 0.4 3e-23 82.5 0.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4158) Phage_integrase PF00589.22 ETO03923.1 - 6.5e-18 65.1 0.0 3.5e-15 56.2 0.0 2.6 1 1 0 1 1 1 1 Phage integrase family FlaF PF07309.11 ETO03924.1 - 0.0046 16.9 2.6 0.009 16.0 2.6 1.5 1 1 0 1 1 1 1 Flagellar protein FlaF P4Ha_N PF08336.11 ETO03924.1 - 0.012 15.6 5.8 0.076 13.0 0.6 2.3 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region CREPT PF16566.5 ETO03924.1 - 0.056 13.6 6.3 0.081 13.1 6.0 1.5 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour IFT46_B_C PF12317.8 ETO03924.1 - 0.061 13.1 3.5 0.088 12.5 3.5 1.3 1 1 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal DUF4951 PF16309.5 ETO03924.1 - 0.062 13.3 0.3 0.062 13.3 0.3 1.8 2 0 0 2 2 2 0 Domian of unknown function (DUF4951) Lipoprotein_3 PF00938.17 ETO03924.1 - 0.085 13.0 3.4 0.58 10.4 0.6 2.5 2 1 1 3 3 3 0 Lipoprotein SAICAR_synt PF01259.18 ETO03924.1 - 0.089 12.4 3.9 0.32 10.6 4.0 1.7 1 1 0 1 1 1 0 SAICAR synthetase UDPG_MGDP_dh_N PF03721.14 ETO03924.1 - 0.1 12.2 2.0 0.14 11.7 1.3 1.6 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain TMPIT PF07851.13 ETO03924.1 - 0.65 9.2 5.3 0.45 9.7 3.9 1.4 1 1 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 ETO03924.1 - 0.88 9.6 8.0 0.13 12.3 3.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 ETO03924.1 - 1.4 8.9 14.8 1.5 8.9 14.0 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 ETO03924.1 - 1.7 8.8 7.5 0.37 11.0 3.5 1.8 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family tRNA-synt_1b PF00579.25 ETO03925.1 - 1e-12 48.0 0.2 6e-12 45.5 0.0 1.9 1 1 1 2 2 2 2 tRNA synthetases class I (W and Y) ZapB PF06005.12 ETO03928.1 - 0.0059 17.0 3.0 0.033 14.6 1.1 2.3 2 0 0 2 2 2 1 Cell division protein ZapB HALZ PF02183.18 ETO03928.1 - 0.019 15.2 3.9 0.041 14.1 2.4 2.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper JIP_LZII PF16471.5 ETO03928.1 - 0.04 14.1 2.4 0.053 13.7 0.5 2.0 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF2972 PF11186.8 ETO03928.1 - 0.075 12.9 1.2 0.084 12.8 0.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2972) DUF3450 PF11932.8 ETO03928.1 - 0.16 11.2 2.9 0.16 11.2 2.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) ATP-synt_ab_N PF02874.23 ETO03931.1 - 5.4e-06 26.8 0.0 1.4e-05 25.5 0.0 1.6 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Kelch_6 PF13964.6 ETO03933.1 - 0.00026 21.1 0.1 0.00063 19.9 0.1 1.7 1 0 0 1 1 1 1 Kelch motif Kelch_1 PF01344.25 ETO03933.1 - 0.00032 20.2 0.0 0.00066 19.2 0.0 1.5 1 0 0 1 1 1 1 Kelch motif Period_C PF12114.8 ETO03933.1 - 7.1 6.2 12.6 11 5.5 12.6 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region DUF3827 PF12877.7 ETO03933.1 - 8.2 4.7 5.0 11 4.3 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) DAGK_cat PF00781.24 ETO03934.1 - 5.9e-05 22.7 0.2 0.00015 21.4 0.0 1.6 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain DUF4588 PF15251.6 ETO03934.1 - 0.0095 15.7 3.3 0.0098 15.7 2.4 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4588) Na_trans_assoc PF06512.13 ETO03934.1 - 0.099 12.9 8.9 0.11 12.8 8.9 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated ASFV_J13L PF05568.11 ETO03934.1 - 4.2 7.1 4.7 0.83 9.4 1.1 1.6 2 0 0 2 2 2 0 African swine fever virus J13L protein BUD22 PF09073.10 ETO03934.1 - 4.6 6.5 14.2 4.8 6.4 14.2 1.0 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 ETO03934.1 - 5.3 5.5 18.5 6.2 5.3 18.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SAPS PF04499.15 ETO03935.1 - 1e-10 41.1 0.2 1e-10 41.1 0.2 2.1 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein Pes-10 PF07149.11 ETO03935.1 - 0.031 13.3 2.2 0.048 12.7 2.2 1.3 1 0 0 1 1 1 0 Pes-10 DUF5102 PF17104.5 ETO03935.1 - 0.22 11.5 8.1 0.45 10.5 8.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) RRN3 PF05327.11 ETO03935.1 - 0.28 9.7 4.7 0.44 9.0 4.7 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sigma70_ner PF04546.13 ETO03935.1 - 4.9 7.0 8.5 7.6 6.4 7.8 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region ABC_tran PF00005.27 ETO03936.1 - 7.9e-12 45.9 0.7 2e-11 44.5 0.2 2.0 2 1 0 2 2 2 1 ABC transporter ABC_tran_Xtn PF12848.7 ETO03936.1 - 9.1e-09 35.2 1.5 1.3e-08 34.8 1.5 1.2 1 0 0 1 1 1 1 ABC transporter DUF87 PF01935.17 ETO03936.1 - 0.00082 19.5 0.4 0.0017 18.5 0.1 1.6 2 0 0 2 2 2 1 Helicase HerA, central domain NACHT PF05729.12 ETO03936.1 - 0.0027 17.6 0.0 0.08 12.9 0.0 2.3 1 1 1 2 2 2 1 NACHT domain AAA_29 PF13555.6 ETO03936.1 - 0.0053 16.5 1.9 0.011 15.5 0.7 2.0 1 1 1 2 2 2 1 P-loop containing region of AAA domain AAA PF00004.29 ETO03936.1 - 0.015 15.7 0.0 0.2 12.1 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO03936.1 - 0.016 15.6 0.0 0.037 14.4 0.0 1.6 1 1 1 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETO03936.1 - 0.016 15.5 0.0 0.41 10.9 0.0 2.2 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 ETO03936.1 - 0.022 13.9 0.0 0.045 12.9 0.0 1.6 1 1 0 1 1 1 0 NB-ARC domain MeaB PF03308.16 ETO03936.1 - 0.023 13.7 0.0 0.036 13.0 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ETO03936.1 - 0.034 14.3 0.0 0.091 12.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ETO03936.1 - 0.034 14.0 2.4 0.059 13.2 0.2 2.2 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 ETO03936.1 - 0.034 13.3 0.0 0.051 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RsgA_GTPase PF03193.16 ETO03936.1 - 0.036 14.0 0.3 0.092 12.7 0.3 1.7 1 1 1 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 ETO03936.1 - 0.042 14.3 0.1 0.64 10.4 0.0 2.4 1 1 1 2 2 2 0 RNA helicase Roc PF08477.13 ETO03936.1 - 0.044 14.0 0.0 0.49 10.6 0.0 2.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase AAA_7 PF12775.7 ETO03936.1 - 0.048 13.2 0.1 0.2 11.2 0.0 1.9 1 1 1 2 2 2 0 P-loop containing dynein motor region SMC_N PF02463.19 ETO03936.1 - 0.066 12.6 0.1 0.11 11.9 0.1 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ETO03936.1 - 0.067 13.3 0.0 0.2 11.7 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 ETO03936.1 - 0.089 12.5 0.0 0.47 10.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain G-alpha PF00503.20 ETO03936.1 - 0.11 11.7 0.7 0.13 11.3 0.1 1.4 2 0 0 2 2 2 0 G-protein alpha subunit AAA_18 PF13238.6 ETO03936.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.8 2 0 0 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ETO03936.1 - 0.18 11.1 0.0 0.38 10.0 0.0 1.6 1 1 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 ETO03936.1 - 0.18 12.2 0.1 0.18 12.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain Glyco_transf_17 PF04724.13 ETO03937.1 - 0.013 14.6 0.1 0.014 14.5 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 17 PrkA PF06798.12 ETO03938.1 - 0.03 13.9 4.8 0.045 13.4 4.5 1.4 1 1 0 1 1 1 0 PrkA serine protein kinase C-terminal domain DDR PF08841.10 ETO03938.1 - 0.083 11.9 0.9 0.13 11.3 0.9 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain DUF1623 PF07785.11 ETO03938.1 - 0.45 10.7 6.1 0.13 12.4 0.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1623) zf-C2H2_4 PF13894.6 ETO03939.1 - 0.065 14.1 4.8 1.4 10.0 0.2 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO03939.1 - 0.35 11.4 5.8 0.76 10.3 0.2 2.5 2 0 0 2 2 2 0 Zinc finger, C2H2 type Serglycin PF04360.12 ETO03940.1 - 0.0014 18.5 0.0 0.0022 17.9 0.0 1.4 1 0 0 1 1 1 1 Serglycin ATP-synt_D PF01813.17 ETO03942.1 - 8.2e-31 107.4 1.6 9e-31 107.2 1.6 1.0 1 0 0 1 1 1 1 ATP synthase subunit D GAS PF13851.6 ETO03942.1 - 0.032 13.6 1.1 0.039 13.3 1.1 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding AIRS_C PF02769.22 ETO03943.1 - 0.0012 19.0 0.0 0.002 18.3 0.0 1.4 1 0 0 1 1 1 1 AIR synthase related protein, C-terminal domain AIRS PF00586.24 ETO03943.1 - 0.0015 19.2 0.2 0.0026 18.4 0.2 1.4 1 0 0 1 1 1 1 AIR synthase related protein, N-terminal domain FH2 PF02181.23 ETO03944.1 - 4.7e-24 85.2 0.0 5.6e-24 85.0 0.0 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain FtsK_gamma PF09397.10 ETO03945.1 - 0.046 13.5 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Ftsk gamma domain ResIII PF04851.15 ETO03945.1 - 0.7 9.9 5.6 0.33 10.9 0.9 2.1 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit DUF3899 PF13038.6 ETO03946.1 - 0.16 12.5 0.6 0.16 12.5 0.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) SpoIIIAH PF12685.7 ETO03946.1 - 0.31 10.8 10.6 0.34 10.7 10.6 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein DOR PF14839.6 ETO03946.1 - 0.48 10.3 9.5 0.58 10.1 9.5 1.1 1 0 0 1 1 1 0 DOR family SLBB PF10531.9 ETO03947.1 - 0.07 13.0 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 SLBB domain Actin PF00022.19 ETO03949.1 - 2e-15 56.3 0.0 2.5e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 Actin PilM_2 PF11104.8 ETO03949.1 - 0.016 14.3 0.0 0.024 13.7 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; Xpo1 PF08389.12 ETO03950.1 - 1e-14 54.9 0.1 1.6e-14 54.2 0.1 1.4 1 0 0 1 1 1 1 Exportin 1-like protein DUF1892 PF08987.10 ETO03950.1 - 0.88 9.8 4.0 19 5.5 0.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1892) Ldl_recept_a PF00057.18 ETO03951.1 - 7.2e-06 26.1 7.8 7.2e-06 26.1 7.8 2.2 2 0 0 2 2 2 1 Low-density lipoprotein receptor domain class A HYR PF02494.16 ETO03951.1 - 1.7e-05 25.1 0.0 5.7e-05 23.4 0.0 1.9 1 0 0 1 1 1 1 HYR domain DUF4446 PF14584.6 ETO03951.1 - 0.22 11.5 0.1 0.22 11.5 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) Kelch_1 PF01344.25 ETO03952.1 - 0.014 15.0 0.1 0.26 10.9 0.0 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO03952.1 - 0.082 12.9 0.2 4.1 7.5 0.0 2.7 2 1 0 2 2 2 0 Kelch motif COesterase PF00135.28 ETO03955.1 - 0.00027 20.0 0.1 0.00059 18.8 0.0 1.5 1 1 0 1 1 1 1 Carboxylesterase family Afi1 PF07792.12 ETO03955.1 - 0.1 13.1 0.5 0.14 12.6 0.5 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CorA PF01544.18 ETO03957.1 - 0.04 13.2 1.8 0.14 11.5 0.1 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein Cbl_N2 PF02761.14 ETO03958.1 - 0.068 13.9 0.0 0.14 12.9 0.0 1.5 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain Dynactin_p22 PF07426.11 ETO03959.1 - 0.00035 20.5 0.7 0.00076 19.4 0.3 1.8 2 0 0 2 2 2 1 Dynactin subunit p22 DUF2959 PF11172.8 ETO03959.1 - 0.15 12.2 2.3 0.26 11.4 0.6 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2959) DUF5344 PF17279.2 ETO03959.1 - 0.23 12.1 1.3 0.79 10.3 0.5 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5344) NPR3 PF03666.13 ETO03960.1 - 0.019 13.8 12.4 0.023 13.5 12.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 ETO03960.1 - 0.07 12.1 5.2 0.081 11.9 5.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CLN3 PF02487.17 ETO03960.1 - 0.072 12.1 1.7 0.094 11.7 1.7 1.1 1 0 0 1 1 1 0 CLN3 protein Menin PF05053.13 ETO03960.1 - 0.097 11.0 9.4 0.098 11.0 9.4 1.0 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.16 ETO03960.1 - 0.18 11.9 5.9 0.2 11.7 5.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PPL5 PF18168.1 ETO03960.1 - 0.29 10.4 6.5 0.36 10.1 6.5 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Zip PF02535.22 ETO03960.1 - 0.31 10.2 9.6 0.37 10.0 9.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 ETO03960.1 - 0.47 9.2 8.0 0.54 9.0 8.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO03960.1 - 0.61 8.8 14.4 0.75 8.5 14.4 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 ETO03960.1 - 0.63 8.4 2.6 0.71 8.2 2.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FAM220 PF15487.6 ETO03960.1 - 0.94 9.1 11.5 1.1 8.8 11.5 1.1 1 0 0 1 1 1 0 FAM220 family Mem_trans PF03547.18 ETO03960.1 - 1.3 7.3 2.9 1.5 7.2 2.9 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF1980 PF09323.10 ETO03960.1 - 1.3 8.9 10.5 1.8 8.4 10.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) DUF4614 PF15391.6 ETO03960.1 - 1.5 8.7 13.8 1.9 8.5 13.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) RR_TM4-6 PF06459.12 ETO03960.1 - 2 8.2 13.9 2.4 7.9 13.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO03960.1 - 2.8 6.1 15.3 3.4 5.8 15.3 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 ETO03960.1 - 3.1 6.7 13.0 3.4 6.6 13.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 AIF_C PF14721.6 ETO03960.1 - 3.7 7.9 10.0 6.7 7.1 10.0 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Macoilin PF09726.9 ETO03960.1 - 3.9 5.9 17.6 4.5 5.7 17.6 1.0 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 ETO03960.1 - 5.8 4.9 10.9 7.4 4.6 10.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Tim54 PF11711.8 ETO03960.1 - 9.9 4.8 13.9 12 4.6 13.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TPR_7 PF13176.6 ETO03961.1 - 1e-05 25.2 0.3 0.24 11.5 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO03961.1 - 0.00015 21.6 0.4 1.7 9.0 0.2 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO03961.1 - 0.00053 20.2 0.6 1 9.7 0.0 2.5 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO03961.1 - 0.018 15.2 0.2 1.1 9.4 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03961.1 - 0.027 14.3 0.1 0.44 10.5 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO03961.1 - 0.13 12.2 0.8 14 5.7 0.2 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO03961.1 - 0.14 12.9 0.1 40 5.1 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat CCDC74_C PF14917.6 ETO03962.1 - 8.5e-05 23.1 1.1 8.5e-05 23.1 1.1 1.4 1 1 0 1 1 1 1 Coiled coil protein 74, C terminal zf-IS66 PF13005.7 ETO03962.1 - 0.048 14.1 0.2 0.18 12.2 0.1 2.0 2 0 0 2 2 2 0 zinc-finger binding domain of transposase IS66 SlyX PF04102.12 ETO03962.1 - 0.057 14.0 0.0 0.08 13.6 0.0 1.3 1 0 0 1 1 1 0 SlyX DUF16 PF01519.16 ETO03962.1 - 0.058 13.9 0.5 0.14 12.7 0.6 1.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 Cnd1 PF12717.7 ETO03964.1 - 2.4e-28 99.2 0.1 3.8e-28 98.5 0.1 1.3 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETO03964.1 - 1.5e-24 86.5 0.6 1.6e-24 86.3 0.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 ETO03964.1 - 5.7e-07 29.8 0.5 0.054 13.9 0.0 2.9 1 1 2 3 3 3 2 HEAT repeats HEAT PF02985.22 ETO03964.1 - 1.6e-05 24.7 1.7 0.02 15.1 0.1 3.5 3 0 0 3 3 3 1 HEAT repeat Arm PF00514.23 ETO03964.1 - 7.7e-05 22.6 1.0 1.1 9.4 0.0 3.5 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO03964.1 - 0.00099 19.6 0.0 1.2 9.7 0.0 2.7 2 1 1 3 3 3 2 HEAT-like repeat MMS19_C PF12460.8 ETO03964.1 - 0.013 14.7 0.2 0.014 14.5 0.2 1.2 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal Nipped-B_C PF12830.7 ETO03964.1 - 0.088 12.7 0.0 1.3 8.9 0.0 2.3 2 1 0 2 2 2 0 Sister chromatid cohesion C-terminus ABC2_membrane PF01061.24 ETO03965.1 - 4.4e-07 29.5 3.9 4.4e-07 29.5 3.9 2.1 2 0 0 2 2 2 2 ABC-2 type transporter Ldh_1_C PF02866.18 ETO03965.1 - 0.0096 15.9 0.0 0.013 15.5 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF4082 PF13313.6 ETO03965.1 - 0.013 15.5 0.0 0.02 14.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) DUF1664 PF07889.12 ETO03966.1 - 0.022 14.8 4.3 0.026 14.6 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FAA_hydro_N_2 PF18288.1 ETO03966.1 - 0.027 14.9 1.0 0.071 13.5 0.3 1.8 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 DUF883 PF05957.13 ETO03966.1 - 0.12 13.0 4.9 1.2 9.8 2.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF948 PF06103.11 ETO03966.1 - 0.14 12.4 2.4 0.23 11.8 2.4 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF3288 PF11691.8 ETO03966.1 - 0.19 11.8 3.9 1.3 9.1 3.9 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3288) DUF1043 PF06295.12 ETO03966.1 - 0.29 11.2 6.1 0.38 10.8 6.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Bap31_Bap29_C PF18035.1 ETO03966.1 - 0.29 11.1 4.8 0.58 10.2 4.8 1.6 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain YabA PF06156.13 ETO03966.1 - 0.35 11.5 8.0 0.42 11.3 8.0 1.1 1 0 0 1 1 1 0 Initiation control protein YabA zf-C4H2 PF10146.9 ETO03966.1 - 0.58 10.4 6.3 0.66 10.2 6.3 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein TMPIT PF07851.13 ETO03966.1 - 4.2 6.5 7.3 4.7 6.4 7.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein Sin3a_C PF16879.5 ETO03967.1 - 7.2e-08 32.5 2.2 5.6e-06 26.3 0.1 2.1 1 1 1 2 2 2 2 C-terminal domain of Sin3a protein CFTR_R PF14396.6 ETO03967.1 - 0.11 12.0 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Cystic fibrosis TM conductance regulator (CFTR), regulator domain DUF1539 PF07560.11 ETO03968.1 - 0.054 13.6 0.4 0.094 12.8 0.0 1.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) Thermopsin PF05317.11 ETO03968.1 - 0.12 11.9 2.5 0.12 11.8 2.5 1.2 1 0 0 1 1 1 0 Thermopsin DUF627 PF04781.12 ETO03971.1 - 0.088 12.8 0.3 0.15 12.1 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF627) Cdh1_DBD_1 PF18196.1 ETO03972.1 - 0.026 14.8 0.8 0.043 14.1 0.8 1.4 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Nucleoside_tran PF01733.18 ETO03972.1 - 0.17 11.2 0.5 0.19 11.1 0.5 1.1 1 0 0 1 1 1 0 Nucleoside transporter eIF3_subunit PF08597.10 ETO03973.1 - 0.00029 20.9 2.7 0.00029 20.9 2.7 1.1 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit FAM60A PF15396.6 ETO03973.1 - 0.019 15.0 1.7 0.02 14.9 1.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 ETO03973.1 - 0.13 11.0 2.4 0.13 11.1 2.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Striatin PF08232.12 ETO03973.1 - 0.34 11.5 8.2 0.4 11.3 8.2 1.1 1 0 0 1 1 1 0 Striatin family DUF1754 PF08555.10 ETO03973.1 - 4.1 8.3 17.1 5.3 7.9 17.1 1.2 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Dynamitin PF04912.14 ETO03974.1 - 3.7e-12 46.3 9.8 4.1e-12 46.1 9.8 1.0 1 0 0 1 1 1 1 Dynamitin PilJ PF13675.6 ETO03974.1 - 0.016 15.2 2.0 0.03 14.4 2.0 1.4 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term EMP24_GP25L PF01105.24 ETO03974.1 - 0.025 14.5 1.8 0.025 14.5 1.8 1.7 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD HEPN PF05168.14 ETO03974.1 - 0.039 14.1 0.4 0.085 13.0 0.3 1.7 1 1 0 1 1 1 0 HEPN domain SAP18 PF06487.12 ETO03974.1 - 0.045 13.9 1.6 0.06 13.5 1.6 1.2 1 0 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) IL2 PF00715.17 ETO03974.1 - 0.23 11.4 3.6 0.32 10.9 3.6 1.2 1 0 0 1 1 1 0 Interleukin 2 Prominin PF05478.11 ETO03974.1 - 0.3 9.0 4.3 0.36 8.7 4.3 1.1 1 0 0 1 1 1 0 Prominin LETM1 PF07766.13 ETO03974.1 - 0.74 9.1 8.7 0.85 8.9 8.7 1.1 1 0 0 1 1 1 0 LETM1-like protein RNA_pol_Rpb4 PF03874.16 ETO03974.1 - 4.8 7.5 9.2 2.2 8.6 5.8 1.9 2 0 0 2 2 2 0 RNA polymerase Rpb4 Ribosomal_L24e PF01246.20 ETO03975.1 - 0.068 13.4 0.0 0.1 12.9 0.0 1.2 1 0 0 1 1 1 0 Ribosomal protein L24e polyprenyl_synt PF00348.17 ETO03976.1 - 0.057 12.5 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 Polyprenyl synthetase ORC_WH_C PF18137.1 ETO03977.1 - 0.054 13.6 14.1 0.12 12.4 14.1 1.6 1 1 0 1 1 1 0 Origin recognition complex winged helix C-terminal TBCC_N PF16752.5 ETO03977.1 - 0.097 13.1 13.4 0.098 13.1 5.4 2.1 2 0 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain RNA_pol_Rpb1_1 PF04997.12 ETO03977.1 - 0.14 11.5 8.0 0.15 11.3 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 1 CDT1_C PF16679.5 ETO03977.1 - 0.17 12.4 0.4 0.17 12.4 0.4 2.3 2 1 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain Med30 PF11315.8 ETO03977.1 - 0.51 10.5 10.5 0.7 10.1 10.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 30 KIP1 PF07765.12 ETO03977.1 - 1.5 9.0 8.3 0.23 11.6 1.4 2.5 2 1 1 3 3 3 0 KIP1-like protein Spot_14 PF07084.12 ETO03977.1 - 5 7.3 10.2 40 4.3 10.2 2.0 1 1 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 Rpn3_C PF08375.11 ETO03977.1 - 9 6.8 10.6 7.5 7.1 1.5 2.5 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal Cullin PF00888.22 ETO03978.1 - 4.8e-41 141.1 8.2 5.2e-41 141.0 8.2 1.0 1 0 0 1 1 1 1 Cullin family zf-H2C2_2 PF13465.6 ETO03980.1 - 2.3e-05 24.6 1.1 2.3e-05 24.6 1.1 2.8 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO03980.1 - 0.00011 22.7 7.6 0.016 16.0 0.2 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-BED PF02892.15 ETO03980.1 - 0.028 14.5 8.1 0.42 10.7 1.6 2.4 1 1 1 2 2 2 0 BED zinc finger zf-C2H2 PF00096.26 ETO03980.1 - 0.098 13.2 7.8 2.9 8.5 2.2 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 ETO03980.1 - 0.11 12.2 0.7 4.9 7.0 0.0 2.2 2 0 0 2 2 2 0 zinc-finger C2H2-type PyrI_C PF02748.15 ETO03980.1 - 0.64 10.0 4.8 4 7.4 0.7 2.5 1 1 1 2 2 2 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_2 PF12756.7 ETO03980.1 - 6 7.3 11.8 2.4 8.5 0.3 2.8 2 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) Suf PF05843.14 ETO03981.1 - 2.9 7.8 14.5 4.5 7.2 14.5 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF4512 PF14975.6 ETO03982.1 - 0.073 13.8 0.2 0.19 12.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Toxin_17 PF08086.11 ETO03982.1 - 0.13 12.6 1.4 0.24 11.7 0.2 1.9 2 0 0 2 2 2 0 Ergtoxin family ATG7_N PF16420.5 ETO03984.1 - 0.0084 15.8 0.7 0.0086 15.8 0.7 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus SLX9 PF15341.6 ETO03984.1 - 0.021 15.2 4.3 0.034 14.5 4.3 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 TFR_dimer PF04253.15 ETO03984.1 - 0.029 14.5 0.6 0.055 13.6 0.5 1.5 1 1 0 1 1 1 0 Transferrin receptor-like dimerisation domain DUF1840 PF08895.11 ETO03984.1 - 0.039 14.3 0.4 0.071 13.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) NADH_4Fe-4S PF10589.9 ETO03984.1 - 0.17 12.0 0.1 0.28 11.3 0.1 1.3 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region YfhO PF09586.10 ETO03985.1 - 0.035 12.4 2.8 0.042 12.1 2.8 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO TssN PF17555.2 ETO03985.1 - 0.11 11.9 3.5 0.14 11.5 3.5 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssN Shikimate_DH PF01488.20 ETO03986.1 - 6e-06 26.4 0.1 0.031 14.3 0.1 2.1 2 0 0 2 2 2 2 Shikimate / quinate 5-dehydrogenase OCD_Mu_crystall PF02423.15 ETO03986.1 - 0.049 12.6 0.0 0.072 12.0 0.0 1.4 1 1 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family DAHP_synth_2 PF01474.16 ETO03986.1 - 0.084 11.4 0.0 0.13 10.7 0.0 1.3 1 1 0 1 1 1 0 Class-II DAHP synthetase family DASH_Dad1 PF08649.10 ETO03986.1 - 0.13 12.4 0.0 0.2 11.8 0.0 1.3 1 0 0 1 1 1 0 DASH complex subunit Dad1 Pkinase PF00069.25 ETO03987.1 - 1.7e-12 47.3 0.1 2e-12 47.1 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO03987.1 - 3.5e-07 29.8 0.0 4.7e-07 29.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO03987.1 - 0.0016 17.8 0.1 0.0016 17.8 0.1 1.3 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO03987.1 - 0.0079 15.0 0.6 0.0083 14.9 0.6 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO03987.1 - 0.0091 15.0 0.1 0.011 14.7 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ETO03987.1 - 0.029 14.0 0.1 0.048 13.3 0.1 1.4 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 ETO03987.1 - 0.04 13.5 0.1 0.052 13.1 0.1 1.2 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ETO03987.1 - 0.058 13.3 0.1 0.072 13.0 0.1 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family UCH PF00443.29 ETO03988.1 - 1.7e-08 34.3 4.5 4.3e-08 33.0 4.5 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO03988.1 - 0.028 14.0 0.5 0.028 14.0 0.5 2.0 1 1 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase BNR_assoc_N PF14873.6 ETO03989.1 - 0.017 14.8 0.6 0.022 14.5 0.6 1.3 1 0 0 1 1 1 0 N-terminal domain of BNR-repeat neuraminidase Carboxyl_trans PF01039.22 ETO03990.1 - 5.1e-35 121.0 0.0 6.3e-35 120.7 0.0 1.0 1 0 0 1 1 1 1 Carboxyl transferase domain ECH_1 PF00378.20 ETO03990.1 - 0.17 11.1 0.1 0.24 10.7 0.1 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase COX17 PF05051.13 ETO03991.1 - 0.016 15.5 2.0 0.035 14.5 2.0 1.5 1 0 0 1 1 1 0 Cytochrome C oxidase copper chaperone (COX17) Glycohydro_20b2 PF14845.6 ETO03992.1 - 6.6 7.4 8.5 56 4.4 8.5 2.0 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like Glyco_transf_8 PF01501.20 ETO03994.1 - 0.0015 18.1 2.3 0.0019 17.8 2.3 1.4 1 1 0 1 1 1 1 Glycosyl transferase family 8 CDC45 PF02724.14 ETO03994.1 - 1.1 7.5 17.0 1.3 7.2 17.0 1.0 1 0 0 1 1 1 0 CDC45-like protein RVT_1 PF00078.27 ETO03995.1 - 9.9e-56 188.7 1.9 2.2e-55 187.6 1.9 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4417 PF14386.6 ETO03995.1 - 0.027 14.1 0.1 0.069 12.7 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4417) DUF1882 PF08966.11 ETO03995.1 - 0.89 9.9 4.5 0.39 11.0 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) SAM_1 PF00536.30 ETO03996.1 - 4.3e-12 46.3 1.7 4.3e-12 46.3 1.7 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO03996.1 - 6e-11 42.3 0.7 9.6e-11 41.6 0.7 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Pox_F12L PF03337.13 ETO03996.1 - 9.3e-05 20.8 0.1 0.00011 20.6 0.1 1.1 1 0 0 1 1 1 1 Poxvirus F12L protein CRA PF06589.11 ETO03996.1 - 0.018 15.2 7.0 0.023 14.8 7.0 1.4 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) PA26 PF04636.13 ETO03996.1 - 0.027 13.4 2.2 0.027 13.4 2.2 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) PepSY_TM_like_2 PF16357.5 ETO03996.1 - 0.035 14.1 0.8 0.043 13.8 0.8 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like PAP_central PF04928.17 ETO03996.1 - 0.036 13.1 0.8 0.042 12.8 0.8 1.1 1 0 0 1 1 1 0 Poly(A) polymerase central domain LMBR1 PF04791.16 ETO03996.1 - 0.35 9.7 2.8 0.35 9.7 2.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein C2 PF00168.30 ETO03997.1 - 2.6e-12 46.9 0.0 5.1e-12 46.0 0.0 1.5 1 0 0 1 1 1 1 C2 domain TPR_2 PF07719.17 ETO03998.1 - 4e-07 29.7 1.6 0.00049 20.0 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO03998.1 - 9.5e-07 28.4 2.7 0.0018 18.0 0.9 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO03998.1 - 1.1e-05 25.5 0.4 1.5e-05 25.1 0.4 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO03998.1 - 0.0014 19.2 1.0 0.055 14.1 0.2 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat NYD-SP12_N PF15015.6 ETO03998.1 - 0.0064 14.9 0.1 0.0066 14.9 0.1 1.2 1 0 0 1 1 1 1 Spermatogenesis-associated, N-terminal TPR_12 PF13424.6 ETO03998.1 - 0.016 15.5 0.5 1.1 9.6 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO03998.1 - 0.078 13.2 5.3 0.38 11.0 5.3 2.2 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO03998.1 - 0.1 13.1 3.8 0.17 12.4 2.4 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat O-antigen_lig PF13425.6 ETO03998.1 - 0.27 10.0 0.8 0.31 9.8 0.8 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Mob1_phocein PF03637.17 ETO03999.1 - 1.5e-25 90.1 8.2 1.9e-25 89.9 8.2 1.1 1 0 0 1 1 1 1 Mob1/phocein family G10 PF01125.17 ETO04000.1 - 0.011 15.5 0.0 0.011 15.4 0.0 1.2 1 0 0 1 1 1 0 G10 protein RRM_1 PF00076.22 ETO04002.1 - 1.9e-28 98.1 0.9 3.5e-15 55.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO04002.1 - 6.2e-07 29.4 0.1 0.019 15.1 0.0 2.8 2 1 0 2 2 2 2 RNA recognition motif WD40 PF00400.32 ETO04003.1 - 9.1e-28 96.0 14.2 6.2e-09 36.4 1.3 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04003.1 - 1e-17 64.2 0.0 7.6e-06 26.1 0.0 5.7 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO04003.1 - 0.0015 18.4 0.0 1.6 8.7 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO04003.1 - 0.01 14.9 0.3 0.46 9.5 0.1 2.6 2 1 1 3 3 3 0 Coatomer WD associated region OAR PF03826.17 ETO04003.1 - 0.16 11.8 0.7 0.52 10.2 0.7 2.0 1 0 0 1 1 1 0 OAR domain TFIIIC_delta PF12657.7 ETO04003.1 - 0.36 10.7 3.6 6.5 6.6 0.0 3.8 3 1 0 4 4 4 0 Transcription factor IIIC subunit delta N-term SUIM_assoc PF16619.5 ETO04004.1 - 0.014 15.5 2.6 0.014 15.5 2.6 1.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Gal_GalNac_35kD PF17337.2 ETO04004.1 - 0.027 14.5 0.1 0.044 13.8 0.0 1.3 1 1 0 1 1 1 0 Galactose-inhibitable lectin 35 kDa subunit Aha1_N PF09229.11 ETO04006.1 - 5.3e-06 26.7 0.3 6.6e-06 26.4 0.3 1.1 1 0 0 1 1 1 1 Activator of Hsp90 ATPase, N-terminal D123 PF07065.14 ETO04007.1 - 3.1e-14 52.9 1.3 2e-13 50.2 1.3 1.9 1 1 0 1 1 1 1 D123 R2K_2 PF18299.1 ETO04007.1 - 0.008 16.0 0.0 0.015 15.1 0.0 1.4 1 1 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 Pkinase PF00069.25 ETO04008.1 - 8.8e-20 71.2 0.6 1e-19 70.9 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04008.1 - 1.9e-07 30.6 0.3 2.1e-07 30.5 0.3 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO04008.1 - 0.0001 21.7 0.6 0.00011 21.7 0.6 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO04008.1 - 0.0005 18.9 0.7 0.00068 18.5 0.7 1.4 1 1 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 ETO04008.1 - 0.013 15.1 1.0 0.016 14.8 1.0 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ETO04008.1 - 0.029 14.3 0.0 0.037 13.9 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ETO04008.1 - 0.041 13.5 0.5 0.054 13.1 0.5 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 IPK PF03770.16 ETO04008.1 - 0.087 12.7 3.8 0.29 11.0 3.8 1.8 1 1 0 1 1 1 0 Inositol polyphosphate kinase SR-25 PF10500.9 ETO04008.1 - 2.3 7.8 10.2 2.8 7.5 10.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ETO04009.1 - 7.9e-11 41.8 0.1 2.7e-10 40.1 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain RGS PF00615.19 ETO04009.1 - 3.9e-06 27.1 0.9 7.2e-06 26.3 0.9 1.6 1 1 0 1 1 1 1 Regulator of G protein signaling domain Pkinase_Tyr PF07714.17 ETO04009.1 - 0.0074 15.6 0.0 0.014 14.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase G-alpha PF00503.20 ETO04010.1 - 2.3e-50 171.8 9.4 2.8e-50 171.5 9.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO04010.1 - 3.7e-10 39.5 0.9 1.6e-06 27.7 0.1 2.5 1 1 1 2 2 2 2 ADP-ribosylation factor family Cullin PF00888.22 ETO04011.1 - 1.5e-30 106.4 2.1 1.6e-30 106.3 2.1 1.0 1 0 0 1 1 1 1 Cullin family Dicty_REP PF05086.12 ETO04012.1 - 0.0037 15.3 7.3 0.0042 15.1 7.3 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Tir_receptor_C PF07489.11 ETO04012.1 - 0.18 11.7 3.8 0.29 11.1 3.8 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus B56 PF01603.20 ETO04013.1 - 2.3e-20 73.0 0.1 2.6e-20 72.8 0.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DUF853 PF05872.12 ETO04014.1 - 2.5 6.6 6.4 2.8 6.4 6.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF4096 PF13340.6 ETO04015.1 - 1.1e-22 80.1 0.3 2e-22 79.2 0.3 1.5 1 0 0 1 1 1 1 Putative transposase of IS4/5 family (DUF4096) DDE_Tnp_1 PF01609.21 ETO04015.1 - 2.2e-21 76.5 0.4 1e-19 71.0 0.4 2.2 1 1 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_2 PF13586.6 ETO04015.1 - 1.6e-15 57.2 0.0 3.4e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_3 PF13612.6 ETO04015.1 - 7.3e-10 39.1 0.0 1.2e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_4 PF13359.6 ETO04015.1 - 9e-08 31.9 0.0 1.6e-07 31.2 0.0 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease SDA1 PF05285.12 ETO04016.1 - 8.7e-05 22.1 12.3 9.2e-05 22.0 12.3 1.1 1 0 0 1 1 1 1 SDA1 Mpp10 PF04006.12 ETO04016.1 - 0.00029 19.4 12.9 0.0003 19.4 12.9 1.0 1 0 0 1 1 1 1 Mpp10 protein DNA_pol_phi PF04931.13 ETO04016.1 - 0.00059 18.1 18.6 0.00074 17.8 18.6 1.1 1 0 0 1 1 1 1 DNA polymerase phi CNDH2_C PF16858.5 ETO04016.1 - 0.00068 19.6 9.0 0.00076 19.4 9.0 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term SAPS PF04499.15 ETO04016.1 - 0.0019 17.1 8.4 0.0021 17.0 8.4 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein BUD22 PF09073.10 ETO04016.1 - 0.0029 17.0 15.0 0.0036 16.7 15.0 1.1 1 0 0 1 1 1 1 BUD22 DUF913 PF06025.12 ETO04016.1 - 0.0041 16.1 3.1 0.0045 16.0 3.1 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) V_ATPase_I PF01496.19 ETO04016.1 - 0.0056 14.7 1.7 0.0058 14.6 1.7 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family NPR3 PF03666.13 ETO04016.1 - 0.007 15.2 10.0 0.0079 15.0 10.0 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO04016.1 - 0.0093 15.2 4.4 0.011 15.0 4.4 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Vfa1 PF08432.10 ETO04016.1 - 0.022 15.1 10.2 0.031 14.6 10.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 ETO04016.1 - 0.024 14.8 3.7 0.027 14.6 3.7 1.2 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.12 ETO04016.1 - 0.031 12.5 19.9 0.042 12.1 19.9 1.2 1 0 0 1 1 1 0 Nop14-like family SID-1_RNA_chan PF13965.6 ETO04016.1 - 0.04 12.3 2.2 0.042 12.3 2.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 ETO04016.1 - 0.067 11.9 7.5 0.083 11.6 7.5 1.1 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.5 ETO04016.1 - 0.091 11.7 0.7 0.11 11.4 0.7 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 ETO04016.1 - 0.094 11.6 0.9 0.11 11.4 0.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) FAM60A PF15396.6 ETO04016.1 - 0.11 12.5 8.6 0.15 12.0 8.6 1.2 1 0 0 1 1 1 0 Protein Family FAM60A FYDLN_acid PF09538.10 ETO04016.1 - 0.11 13.1 22.6 0.46 11.2 22.6 1.9 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF4820 PF16091.5 ETO04016.1 - 0.12 11.7 9.2 0.14 11.5 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Pox_Ag35 PF03286.14 ETO04016.1 - 0.15 11.9 19.2 0.3 10.8 19.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pes-10 PF07149.11 ETO04016.1 - 0.21 10.6 10.7 0.27 10.3 10.7 1.3 1 0 0 1 1 1 0 Pes-10 CPSF100_C PF13299.6 ETO04016.1 - 0.37 11.0 6.3 0.64 10.2 6.3 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 ETO04016.1 - 1 8.1 4.5 1.2 7.8 4.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Nop25 PF09805.9 ETO04016.1 - 1.4 9.4 18.8 2.1 8.8 18.8 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) DUF1980 PF09323.10 ETO04016.1 - 1.9 8.3 9.3 4 7.3 9.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) SLC12 PF03522.15 ETO04016.1 - 2.1 7.3 9.5 2.5 7.0 9.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Connexin PF00029.19 ETO04016.1 - 3.9 7.2 6.1 11 5.7 6.1 1.8 1 1 0 1 1 1 0 Connexin PNISR PF15996.5 ETO04016.1 - 4.2 7.6 14.2 5.7 7.2 14.2 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4746 PF15928.5 ETO04016.1 - 4.8 6.5 11.9 6.2 6.2 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Astro_capsid_p PF12226.8 ETO04016.1 - 5.9 5.9 18.5 9.8 5.2 18.5 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 ETO04016.1 - 8 5.7 29.8 14 4.9 29.8 1.3 1 0 0 1 1 1 0 NOA36 protein PC4 PF02229.16 ETO04019.1 - 7.4e-19 67.1 0.3 1.8e-18 65.9 0.0 1.8 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) Mem_trans PF03547.18 ETO04019.1 - 0.0058 15.1 1.1 0.006 15.0 1.1 1.1 1 0 0 1 1 1 1 Membrane transport protein DUF4318 PF14201.6 ETO04019.1 - 0.012 16.1 0.2 0.18 12.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) KH_9 PF17904.1 ETO04021.1 - 0.011 16.0 0.5 0.016 15.6 0.5 1.3 1 1 0 1 1 1 0 FMRP KH0 domain EF-hand_5 PF13202.6 ETO04021.1 - 0.06 12.9 0.2 0.13 11.8 0.2 1.6 1 0 0 1 1 1 0 EF hand Apis_Csd PF11671.8 ETO04022.1 - 0.4 10.7 4.5 0.58 10.2 4.5 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein Telomere_reg-2 PF10193.9 ETO04023.1 - 1.7e-20 73.5 0.1 2.4e-20 73.0 0.1 1.2 1 0 0 1 1 1 1 Telomere length regulation protein Receptor_2B4 PF11465.8 ETO04024.1 - 0.042 14.0 1.0 0.078 13.2 0.4 1.6 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 GAF PF01590.26 ETO04025.1 - 3.2e-06 27.8 0.0 3.5e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 GAF domain Epimerase PF01370.21 ETO04026.1 - 5.5e-18 65.3 0.0 6.7e-18 65.0 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO04026.1 - 4.9e-11 42.6 0.0 5.1e-11 42.6 0.0 1.0 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ETO04026.1 - 0.06 12.5 0.0 0.06 12.5 0.0 1.1 1 0 0 1 1 1 0 Male sterility protein DUF3336 PF11815.8 ETO04027.1 - 3.1e-11 43.1 0.2 3.5e-11 43.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) DUF1804 PF08822.11 ETO04027.1 - 0.034 14.1 0.0 0.084 12.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1804) PA PF02225.22 ETO04028.1 - 1.1e-08 34.9 0.0 1.7e-08 34.4 0.0 1.3 1 0 0 1 1 1 1 PA domain RhoGEF PF00621.20 ETO04030.1 - 2.1e-21 77.0 0.3 2.7e-21 76.6 0.3 1.1 1 0 0 1 1 1 1 RhoGEF domain SpoIISA_toxin PF14171.6 ETO04030.1 - 0.037 13.7 0.8 0.058 13.1 0.4 1.5 1 1 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system ABC_tran PF00005.27 ETO04031.1 - 5.5e-10 39.9 0.0 7.2e-10 39.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO04031.1 - 4.5e-05 23.4 0.0 5.6e-05 23.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO04031.1 - 0.045 13.2 0.0 0.051 13.0 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain PIN7 PF18475.1 ETO04031.1 - 0.092 13.4 0.0 0.15 12.7 0.0 1.3 1 0 0 1 1 1 0 PIN domain Pkinase PF00069.25 ETO04032.1 - 2e-13 50.4 0.0 5.3e-12 45.7 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04032.1 - 0.0015 17.9 0.0 0.12 11.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Tim54 PF11711.8 ETO04032.1 - 0.021 13.6 1.2 0.022 13.6 1.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CCDC106 PF15794.5 ETO04032.1 - 0.1 12.3 7.8 0.13 11.9 7.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF4614 PF15391.6 ETO04032.1 - 0.14 12.2 6.8 0.16 12.0 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) CDC45 PF02724.14 ETO04032.1 - 1.8 6.7 8.3 2.2 6.5 8.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO04032.1 - 4.2 6.0 5.4 4.7 5.9 5.4 1.1 1 0 0 1 1 1 0 Presenilin TPR_14 PF13428.6 ETO04033.1 - 4e-06 27.2 0.0 0.012 16.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04033.1 - 0.00011 22.0 0.1 0.0096 16.0 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04033.1 - 0.00016 21.6 0.1 0.008 16.3 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO04033.1 - 0.0032 17.7 0.1 0.0056 16.9 0.0 1.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO04033.1 - 0.0097 16.5 0.7 3 8.7 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04033.1 - 0.035 14.0 0.2 0.12 12.3 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04033.1 - 0.043 13.7 0.1 0.73 9.8 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MecA PF05389.12 ETO04034.1 - 0.0088 15.7 2.1 0.01 15.5 2.1 1.0 1 0 0 1 1 1 1 Negative regulator of genetic competence (MecA) Pkinase PF00069.25 ETO04035.1 - 3.7e-41 141.3 0.1 4.1e-41 141.1 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04035.1 - 3.2e-23 82.4 0.0 3.4e-23 82.2 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO04035.1 - 8.6e-06 25.3 0.0 1.6e-05 24.4 0.0 1.4 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO04035.1 - 6.2e-05 22.0 0.2 7e-05 21.8 0.2 1.0 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO04035.1 - 7.5e-05 22.2 0.2 9.6e-05 21.8 0.2 1.1 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO04035.1 - 0.065 12.7 0.0 0.076 12.5 0.0 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF1679 PF07914.11 ETO04035.1 - 0.12 11.3 0.0 0.13 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) Cys_rich_KTR PF14205.6 ETO04037.1 - 0.0022 17.8 0.1 0.0043 16.8 0.1 1.5 1 0 0 1 1 1 1 Cysteine-rich KTR DUF1387 PF07139.11 ETO04038.1 - 0.33 10.6 8.1 0.49 10.1 8.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF1754 PF08555.10 ETO04038.1 - 5 8.0 16.4 1.2 10.0 13.2 1.6 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Pkinase PF00069.25 ETO04039.1 - 0.00055 19.4 0.0 0.0008 18.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain TAF4 PF05236.14 ETO04040.1 - 0.15 11.7 8.5 0.22 11.3 8.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Mating_C PF12737.7 ETO04040.1 - 1.9 7.6 10.1 3.4 6.8 10.1 1.5 1 1 0 1 1 1 0 C-terminal domain of homeodomain 1 Peptidase_C1 PF00112.23 ETO04041.1 - 2.8e-32 112.6 2.3 3.2e-32 112.4 2.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease MscS_TM PF12794.7 ETO04042.1 - 0.0019 17.1 1.2 0.003 16.5 1.2 1.3 1 1 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 CHAT PF12770.7 ETO04042.1 - 0.0066 15.9 0.0 0.0079 15.6 0.0 1.1 1 0 0 1 1 1 1 CHAT domain Col_cuticle_N PF01484.17 ETO04042.1 - 0.013 15.5 0.1 0.028 14.5 0.0 1.6 2 0 0 2 2 2 0 Nematode cuticle collagen N-terminal domain LRR19-TM PF15176.6 ETO04042.1 - 0.014 15.3 0.0 0.023 14.7 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain DoxX_3 PF13781.6 ETO04042.1 - 0.023 15.3 1.5 0.032 14.9 1.5 1.1 1 0 0 1 1 1 0 DoxX-like family DUF5305 PF17231.2 ETO04042.1 - 0.033 13.6 0.1 0.049 13.0 0.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Brr6_like_C_C PF10104.9 ETO04042.1 - 0.037 13.8 0.0 0.26 11.1 0.0 2.0 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain LD_cluster2 PF18163.1 ETO04042.1 - 0.063 12.8 0.3 0.45 10.0 0.1 2.0 2 0 0 2 2 2 0 SLOG cluster2 DUF5534 PF17686.1 ETO04042.1 - 0.16 12.2 1.2 0.56 10.4 1.2 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5534) SIL1 PF16782.5 ETO04042.1 - 0.34 10.1 3.3 0.65 9.2 0.7 1.9 2 0 0 2 2 2 0 Nucleotide exchange factor SIL1 Wzy_C PF04932.15 ETO04042.1 - 0.45 10.1 4.8 0.37 10.4 2.5 1.8 1 1 1 2 2 2 0 O-Antigen ligase eIF2A PF08662.11 ETO04043.1 - 4.8e-06 26.6 0.0 8.8e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A DUF2262 PF10020.9 ETO04043.1 - 0.058 13.8 2.9 0.084 13.3 2.9 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2262) Rrn6 PF10214.9 ETO04044.1 - 0.32 9.5 7.5 0.33 9.4 7.5 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Nucleo_P87 PF07267.11 ETO04044.1 - 2.4 6.9 8.5 2.5 6.8 8.5 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CAML PF14963.6 ETO04044.1 - 2.6 8.1 6.0 3.2 7.8 6.0 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand CDC45 PF02724.14 ETO04044.1 - 6.6 4.9 9.8 6.3 5.0 9.8 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO04045.1 - 0.047 13.0 34.6 0.055 12.8 34.6 1.0 1 0 0 1 1 1 0 BUD22 FXMRP1_C_core PF12235.8 ETO04045.1 - 0.54 10.9 13.1 0.74 10.5 13.1 1.2 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal FAM60A PF15396.6 ETO04045.1 - 0.74 9.8 14.2 0.89 9.5 14.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF3827 PF12877.7 ETO04045.1 - 0.78 8.0 13.6 0.86 7.9 13.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CDC27 PF09507.10 ETO04045.1 - 0.83 9.0 28.0 0.91 8.8 28.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 ETO04045.1 - 1.4 7.6 14.0 1.5 7.5 14.0 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO04045.1 - 2 7.1 23.0 2.4 6.9 23.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FancD2 PF14631.6 ETO04045.1 - 2 5.7 13.9 2.2 5.5 13.9 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF913 PF06025.12 ETO04045.1 - 2.4 7.0 12.0 3 6.7 12.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Dsh_C PF12316.8 ETO04045.1 - 4.4 7.6 9.6 5.4 7.4 9.6 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF2967 PF11179.8 ETO04045.1 - 4.9 5.1 12.9 5.8 4.9 12.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) SLC12 PF03522.15 ETO04045.1 - 5 6.0 11.4 5.5 5.9 11.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Sec62 PF03839.16 ETO04045.1 - 6.8 6.1 14.4 9.1 5.7 14.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 LRIF1 PF15741.5 ETO04045.1 - 7.1 5.0 14.3 8 4.9 14.3 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 RR_TM4-6 PF06459.12 ETO04045.1 - 8 6.2 16.0 11 5.8 16.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Raftlin PF15250.6 ETO04045.1 - 9.5 4.8 14.0 11 4.7 14.0 1.0 1 0 0 1 1 1 0 Raftlin NOA36 PF06524.12 ETO04046.1 - 1.6 8.0 5.7 2.1 7.6 5.7 1.2 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO04046.1 - 2 8.8 5.4 3.2 8.2 5.4 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RIH_assoc PF08454.11 ETO04047.1 - 0.05 13.4 0.0 0.09 12.6 0.0 1.4 1 1 0 1 1 1 0 RyR and IP3R Homology associated Xpo1 PF08389.12 ETO04047.1 - 0.052 13.6 0.0 0.25 11.4 0.0 1.9 2 0 0 2 2 2 0 Exportin 1-like protein Pkinase PF00069.25 ETO04050.1 - 1.6e-29 103.1 0.0 1.8e-29 102.9 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04050.1 - 1.4e-15 57.3 0.0 1.8e-15 57.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO04050.1 - 2.3e-06 26.8 0.0 2.9e-06 26.5 0.0 1.0 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETO04050.1 - 0.0026 17.1 0.1 0.0037 16.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO04050.1 - 0.0036 16.1 0.2 0.74 8.5 0.1 2.0 2 0 0 2 2 2 2 Fungal protein kinase Pox_ser-thr_kin PF05445.11 ETO04050.1 - 0.007 15.4 0.1 0.0097 14.9 0.1 1.2 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase APH PF01636.23 ETO04050.1 - 0.0092 15.9 0.1 0.026 14.4 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO04050.1 - 0.024 14.2 0.2 0.039 13.5 0.2 1.3 1 0 0 1 1 1 0 RIO1 family WD40 PF00400.32 ETO04053.1 - 0.0029 18.4 0.0 0.0052 17.6 0.0 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat TnpV PF14198.6 ETO04054.1 - 0.093 12.7 2.1 0.13 12.2 2.1 1.3 1 0 0 1 1 1 0 Transposon-encoded protein TnpV CortBP2 PF09727.9 ETO04055.1 - 0.37 10.7 25.7 0.32 10.9 24.9 1.3 1 1 0 1 1 1 0 Cortactin-binding protein-2 PRTase_1 PF11202.8 ETO04055.1 - 0.37 10.0 6.8 0.25 10.6 4.6 1.7 1 1 0 1 1 1 0 Phosphoribosyl transferase (PRTase) LIAS_N PF16881.5 ETO04055.1 - 0.51 10.8 8.8 1.2 9.6 8.2 2.1 1 1 0 1 1 1 0 N-terminal domain of lipoyl synthase of Radical_SAM family OmpH PF03938.14 ETO04055.1 - 0.65 10.3 39.4 2.9 8.2 21.2 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4200 PF13863.6 ETO04055.1 - 2.1 8.8 34.1 0.33 11.4 27.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Uso1_p115_C PF04871.13 ETO04055.1 - 6.4 7.2 31.2 0.83 10.0 22.7 2.6 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region CBP_BcsO PF17037.5 ETO04055.1 - 7 6.8 7.1 0.98 9.5 1.9 2.0 1 1 0 2 2 2 0 Cellulose biosynthesis protein BcsO HIP1_clath_bdg PF16515.5 ETO04055.1 - 7.7 7.2 27.9 0.086 13.5 6.0 2.6 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4279 PF14106.6 ETO04055.1 - 7.9 6.7 8.7 67 3.7 8.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4279) Pkinase PF00069.25 ETO04056.1 - 1.1e-38 133.1 0.0 1.4e-38 132.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04056.1 - 6.1e-16 58.5 0.0 7.6e-16 58.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO04056.1 - 0.023 14.6 0.0 0.15 12.0 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ETO04056.1 - 0.052 12.6 0.0 0.052 12.6 0.0 1.8 2 0 0 2 2 2 0 Seadornavirus VP7 Kdo PF06293.14 ETO04056.1 - 0.083 12.2 0.0 0.11 11.9 0.0 1.3 1 1 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF2722 PF10846.8 ETO04057.1 - 0.038 13.0 10.7 0.04 12.9 10.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Ank_2 PF12796.7 ETO04059.1 - 1.1e-09 38.8 0.3 1.4e-09 38.4 0.3 1.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO04059.1 - 2.4e-08 34.3 0.4 6.1e-08 33.1 0.2 1.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO04059.1 - 9.2e-08 31.8 0.5 0.00048 20.4 0.1 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETO04059.1 - 1.1e-07 32.0 0.8 0.00012 22.4 0.2 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO04059.1 - 2.4e-05 24.5 0.1 0.0059 16.9 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) PT PF04886.12 ETO04060.1 - 1.5e-06 27.6 13.9 1.3e-05 24.6 2.3 2.3 1 1 1 2 2 2 2 PT repeat UBA PF00627.31 ETO04061.1 - 7.3e-07 29.0 0.2 1.3e-06 28.1 0.2 1.4 1 0 0 1 1 1 1 UBA/TS-N domain Enkurin PF13864.6 ETO04064.1 - 0.0045 17.4 1.6 0.0045 17.4 1.6 2.8 2 1 0 2 2 2 1 Calmodulin-binding Peptidase_S64 PF08192.11 ETO04064.1 - 0.17 10.3 20.6 0.21 10.0 20.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDC45 PF02724.14 ETO04064.1 - 0.97 7.6 22.8 1.2 7.4 22.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SOBP PF15279.6 ETO04064.1 - 2.4 8.7 11.0 2.8 8.4 11.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Hid1 PF12722.7 ETO04064.1 - 7.2 4.6 17.4 8 4.5 17.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.12 ETO04065.1 - 0.0078 14.5 12.4 0.0097 14.2 12.4 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO04065.1 - 0.028 13.8 14.9 0.033 13.6 14.9 1.1 1 0 0 1 1 1 0 SDA1 CybS PF05328.12 ETO04065.1 - 0.33 10.6 1.2 0.59 9.8 1.2 1.5 1 1 0 1 1 1 0 CybS, succinate dehydrogenase cytochrome B small subunit CDC45 PF02724.14 ETO04065.1 - 0.7 8.1 14.9 0.85 7.8 14.9 1.0 1 0 0 1 1 1 0 CDC45-like protein TRM13 PF05206.14 ETO04065.1 - 7.3 6.0 12.1 0.98 8.9 0.3 2.2 1 1 0 2 2 2 0 Methyltransferase TRM13 LicD PF04991.13 ETO04066.1 - 0.35 11.0 10.3 0.53 10.4 10.3 1.4 1 0 0 1 1 1 0 LicD family DUF966 PF06136.13 ETO04066.1 - 1.6 8.4 27.3 2 8.1 27.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CRT10 PF08728.10 ETO04066.1 - 6.2 4.9 16.3 6.8 4.7 16.3 1.0 1 0 0 1 1 1 0 CRT10 ALMT PF11744.8 ETO04066.1 - 7.7 5.2 18.0 9.2 5.0 18.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 ETO04066.1 - 9.4 5.1 19.8 12 4.8 19.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Mucin PF01456.17 ETO04067.1 - 0.0064 16.5 8.6 0.0086 16.1 8.6 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF771 PF05595.11 ETO04067.1 - 0.025 14.5 0.3 0.31 11.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF771) SOBP PF15279.6 ETO04068.1 - 0.48 11.0 4.9 0.56 10.8 4.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF1103 PF06513.11 ETO04069.1 - 0.035 13.7 0.7 0.041 13.5 0.7 1.1 1 0 0 1 1 1 0 Repeat of unknown function (DUF1103) ANXA2R PF15721.5 ETO04070.1 - 0.054 14.0 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Annexin-2 receptor Parathyroid PF01279.17 ETO04070.1 - 0.068 13.8 1.2 0.23 12.1 1.2 1.8 1 1 0 1 1 1 0 Parathyroid hormone family EF-hand_6 PF13405.6 ETO04070.1 - 0.088 12.8 0.0 0.47 10.5 0.0 2.3 1 1 1 2 2 2 0 EF-hand domain PA PF02225.22 ETO04071.1 - 5.3e-10 39.2 0.0 7.2e-10 38.8 0.0 1.2 1 0 0 1 1 1 1 PA domain ATG16 PF08614.11 ETO04072.1 - 0.00035 20.9 2.5 0.00045 20.5 2.5 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) TolA_bind_tri PF16331.5 ETO04072.1 - 0.00096 19.2 5.7 0.0015 18.6 5.7 1.3 1 0 0 1 1 1 1 TolA binding protein trimerisation DUF648 PF04890.13 ETO04072.1 - 0.0013 18.5 0.9 0.0014 18.4 0.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF648) APG6_N PF17675.1 ETO04072.1 - 0.004 17.7 4.9 0.005 17.4 4.9 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region GAS PF13851.6 ETO04072.1 - 0.0057 16.0 3.7 0.0079 15.6 3.7 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ETO04072.1 - 0.0064 16.5 5.6 0.0076 16.3 5.6 1.1 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 ETO04072.1 - 0.017 15.4 2.3 0.017 15.3 2.3 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 ETO04072.1 - 0.019 15.1 4.7 0.023 14.8 4.7 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus YabA PF06156.13 ETO04072.1 - 0.022 15.4 3.5 0.03 14.9 3.5 1.3 1 0 0 1 1 1 0 Initiation control protein YabA LRRFIP PF09738.9 ETO04072.1 - 0.027 13.9 3.4 0.033 13.7 3.4 1.1 1 0 0 1 1 1 0 LRRFIP family PI3K_P85_iSH2 PF16454.5 ETO04072.1 - 0.029 14.0 5.2 0.035 13.7 5.2 1.1 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Rootletin PF15035.6 ETO04072.1 - 0.05 13.6 5.1 0.071 13.1 5.1 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion bZIP_2 PF07716.15 ETO04072.1 - 0.061 13.4 2.1 0.1 12.7 0.9 1.9 1 1 1 2 2 2 0 Basic region leucine zipper DUF3450 PF11932.8 ETO04072.1 - 0.098 11.9 3.4 0.13 11.6 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO04072.1 - 0.12 12.4 1.3 0.17 11.9 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ZapB PF06005.12 ETO04072.1 - 0.16 12.4 6.5 0.31 11.5 6.5 1.5 1 1 0 1 1 1 0 Cell division protein ZapB Fungal_TACC PF12709.7 ETO04072.1 - 0.26 11.8 5.5 0.19 12.2 2.7 1.9 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Cep57_CLD_2 PF14197.6 ETO04072.1 - 0.42 10.7 5.0 0.5 10.5 1.3 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 Nup54_57_C PF18570.1 ETO04072.1 - 1.2 8.8 0.0 1.2 8.8 0.0 3.1 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain Pterin_bind PF00809.22 ETO04073.1 - 7.8e-50 169.8 0.1 9.1e-50 169.6 0.1 1.0 1 0 0 1 1 1 1 Pterin binding enzyme CdhD PF03599.16 ETO04073.1 - 0.004 15.9 0.0 0.0063 15.3 0.0 1.3 1 0 0 1 1 1 1 CO dehydrogenase/acetyl-CoA synthase delta subunit ComA PF02679.15 ETO04073.1 - 0.037 13.5 1.2 2.8 7.4 0.1 2.2 1 1 0 2 2 2 0 (2R)-phospho-3-sulfolactate synthase (ComA) MBT PF02820.18 ETO04074.1 - 0.00028 21.2 0.1 0.00044 20.5 0.1 1.3 1 0 0 1 1 1 1 mbt repeat Tudor-knot PF11717.8 ETO04074.1 - 0.23 11.4 3.5 0.48 10.3 3.5 1.8 1 1 0 1 1 1 0 RNA binding activity-knot of a chromodomain WD40 PF00400.32 ETO04075.1 - 9.2e-11 42.1 0.3 4.3e-06 27.4 0.2 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04075.1 - 1.7e-07 31.4 0.1 0.004 17.4 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO04075.1 - 0.0023 17.8 0.0 0.11 12.5 0.2 2.4 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Aminotran_4 PF01063.19 ETO04075.1 - 0.0077 16.1 0.0 0.0095 15.8 0.0 1.2 1 0 0 1 1 1 1 Amino-transferase class IV Gmad1 PF10647.9 ETO04075.1 - 0.025 14.3 0.5 0.38 10.4 0.0 2.1 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain Cupin_8 PF13621.6 ETO04076.1 - 1.4e-09 38.1 0.3 1.4e-09 38.1 0.3 1.5 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 ETO04076.1 - 0.00019 21.0 0.1 0.00031 20.3 0.1 1.4 1 1 0 1 1 1 1 Cupin superfamily protein Sulfotransfer_3 PF13469.6 ETO04077.1 - 4.9e-07 30.4 0.0 9.6e-07 29.4 0.0 1.5 1 0 0 1 1 1 1 Sulfotransferase family AAA PF00004.29 ETO04080.1 - 0.026 14.9 0.2 0.1 13.0 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) 5-FTHF_cyc-lig PF01812.20 ETO04080.1 - 0.086 12.7 0.5 0.43 10.4 0.5 2.0 2 0 0 2 2 2 0 5-formyltetrahydrofolate cyclo-ligase family IU_nuc_hydro PF01156.19 ETO04081.1 - 5.3e-33 114.9 0.0 6.2e-33 114.7 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Anoctamin PF04547.12 ETO04082.1 - 3e-31 108.8 2.4 3.1e-31 108.7 2.4 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Cortexin PF11057.8 ETO04082.1 - 0.028 14.3 0.9 0.028 14.3 0.9 1.6 2 0 0 2 2 2 0 Cortexin of kidney DUF3671 PF12420.8 ETO04082.1 - 4.5 7.4 8.3 23 5.1 8.3 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF1387 PF07139.11 ETO04083.1 - 0.16 11.7 16.4 0.16 11.7 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) FAM60A PF15396.6 ETO04083.1 - 0.17 11.8 10.9 0.22 11.5 10.9 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF1754 PF08555.10 ETO04083.1 - 0.77 10.6 24.3 1.2 10.0 24.3 1.3 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) XAP5 PF04921.14 ETO04083.1 - 1.8 8.4 12.7 2.2 8.0 12.7 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator Zip PF02535.22 ETO04083.1 - 2 7.6 5.2 1.8 7.7 5.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Gti1_Pac2 PF09729.9 ETO04083.1 - 3.2 7.8 9.3 3.4 7.7 9.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family NARP1 PF12569.8 ETO04083.1 - 3.3 6.5 14.1 3.3 6.5 14.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Adaptin_binding PF10199.9 ETO04083.1 - 4.1 8.0 12.5 4.7 7.8 12.5 1.1 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Rtf2 PF04641.12 ETO04083.1 - 4.8 6.5 15.1 6.5 6.0 15.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Presenilin PF01080.17 ETO04083.1 - 6.1 5.5 7.7 5.7 5.6 7.7 1.1 1 0 0 1 1 1 0 Presenilin FAM76 PF16046.5 ETO04083.1 - 7.4 5.8 15.5 8.9 5.6 15.5 1.1 1 0 0 1 1 1 0 FAM76 protein RPN2_C PF18004.1 ETO04083.1 - 8.9 6.2 17.6 15 5.4 17.6 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RPOL_N PF14700.6 ETO04084.1 - 0.025 14.0 4.4 0.027 13.9 4.4 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DiS_P_DiS PF06750.13 ETO04084.1 - 0.13 12.4 0.8 0.22 11.6 0.8 1.6 1 1 0 1 1 1 0 Bacterial Peptidase A24 N-terminal domain G-alpha PF00503.20 ETO04085.1 - 1.1e-05 24.7 0.0 1.3e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Pox_P4B PF03292.14 ETO04085.1 - 0.021 13.1 0.1 0.026 12.8 0.1 1.0 1 0 0 1 1 1 0 Poxvirus P4B major core protein Mur_ligase_M PF08245.12 ETO04085.1 - 0.029 14.3 0.0 0.03 14.3 0.0 1.2 1 0 0 1 1 1 0 Mur ligase middle domain Cgr1 PF03879.14 ETO04086.1 - 5.7e-07 29.9 10.2 7.4e-07 29.5 10.2 1.1 1 0 0 1 1 1 1 Cgr1 family SapC PF07277.11 ETO04086.1 - 0.036 13.6 0.8 0.045 13.3 0.8 1.0 1 0 0 1 1 1 0 SapC Fucose_iso_N2 PF07882.12 ETO04086.1 - 0.099 12.2 0.9 0.12 11.9 0.9 1.1 1 0 0 1 1 1 0 L-fucose isomerase, second N-terminal domain PTPlike_phytase PF14566.6 ETO04086.1 - 0.11 12.7 1.8 0.13 12.4 1.8 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate Fib_alpha PF08702.10 ETO04086.1 - 0.25 11.5 4.3 0.33 11.1 4.3 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MDM10 PF12519.8 ETO04086.1 - 0.31 9.8 4.0 0.34 9.7 4.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Tim54 PF11711.8 ETO04087.1 - 0.041 12.7 6.1 0.051 12.4 6.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ECSIT PF06239.11 ETO04087.1 - 0.2 10.7 6.0 0.12 11.5 4.0 1.5 2 0 0 2 2 2 0 Evolutionarily conserved signalling intermediate in Toll pathway MecA PF05389.12 ETO04087.1 - 0.21 11.2 7.3 0.31 10.6 7.3 1.3 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) Presenilin PF01080.17 ETO04087.1 - 0.23 10.2 3.4 0.28 9.9 3.4 1.2 1 0 0 1 1 1 0 Presenilin eIF3_p135 PF12807.7 ETO04087.1 - 0.32 11.0 3.9 0.45 10.5 3.9 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Connexin PF00029.19 ETO04087.1 - 0.46 10.2 4.4 0.69 9.6 4.4 1.3 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 ETO04087.1 - 0.77 9.9 4.3 1.2 9.3 4.3 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NST1 PF13945.6 ETO04087.1 - 4.2 7.4 17.8 5.6 7.0 17.8 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Atrophin-1 PF03154.15 ETO04087.1 - 4.3 5.5 6.8 5.7 5.1 6.8 1.0 1 0 0 1 1 1 0 Atrophin-1 family EpsG PF14897.6 ETO04088.1 - 0.043 13.1 7.7 0.16 11.2 4.9 2.1 2 0 0 2 2 2 0 EpsG family DUF4520 PF15016.6 ETO04088.1 - 0.21 11.7 0.2 0.21 11.7 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4520) DHHC PF01529.20 ETO04088.1 - 6.8 6.8 12.0 17 5.5 6.0 3.3 3 1 0 3 3 3 0 DHHC palmitoyltransferase DUF5436 PF17504.2 ETO04088.1 - 7.5 7.0 8.1 13 6.2 1.1 3.4 4 0 0 4 4 4 0 Family of unknown function (DUF5436) AAA PF00004.29 ETO04089.1 - 1.6e-36 125.6 0.0 5.4e-36 123.9 0.0 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO04089.1 - 5.1e-10 39.0 0.0 4.4e-09 36.0 0.0 2.5 3 0 0 3 3 3 1 AAA+ lid domain Vps4_C PF09336.10 ETO04089.1 - 1.3e-09 38.0 1.1 6.1e-09 35.7 0.1 2.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 ETO04089.1 - 1.4e-05 25.4 0.0 0.00025 21.3 0.0 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETO04089.1 - 1.7e-05 24.7 0.0 3.6e-05 23.5 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ETO04089.1 - 0.00012 22.3 0.0 0.00077 19.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ETO04089.1 - 0.00033 20.7 0.1 0.011 15.7 0.1 2.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETO04089.1 - 0.00064 19.2 0.7 0.0032 16.9 0.1 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ETO04089.1 - 0.0016 18.5 0.0 0.0069 16.4 0.0 2.2 2 0 0 2 2 1 1 AAA domain AAA_18 PF13238.6 ETO04089.1 - 0.0016 19.0 0.1 0.0069 16.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ETO04089.1 - 0.0017 18.1 1.0 0.0043 16.8 0.0 2.2 2 1 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ETO04089.1 - 0.0032 17.2 0.0 0.0063 16.3 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 ETO04089.1 - 0.0071 16.7 0.0 0.039 14.3 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain AAA_28 PF13521.6 ETO04089.1 - 0.01 16.1 0.0 0.026 14.8 0.0 1.7 2 0 0 2 2 1 0 AAA domain ATPase PF06745.13 ETO04089.1 - 0.021 14.2 1.4 0.41 9.9 0.1 2.7 2 1 0 3 3 3 0 KaiC AAA_7 PF12775.7 ETO04089.1 - 0.022 14.3 0.8 0.061 12.8 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_25 PF13481.6 ETO04089.1 - 0.03 13.9 0.1 0.093 12.3 0.0 1.8 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO04089.1 - 0.038 14.4 0.9 0.35 11.3 0.0 3.0 3 1 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 ETO04089.1 - 0.045 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO04089.1 - 0.063 13.0 0.0 0.26 11.0 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain NACHT PF05729.12 ETO04089.1 - 0.077 12.9 0.0 0.53 10.2 0.0 2.2 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 ETO04089.1 - 0.11 12.4 2.7 0.41 10.5 0.0 2.9 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea Seipin PF06775.14 ETO04090.1 - 9.2e-08 32.4 0.0 1.1e-07 32.1 0.0 1.0 1 0 0 1 1 1 1 Putative adipose-regulatory protein (Seipin) Trypan_PARP PF05887.11 ETO04090.1 - 0.00093 19.2 0.2 0.0013 18.8 0.2 1.1 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) FoP_duplication PF13865.6 ETO04090.1 - 0.4 11.3 7.6 0.62 10.7 7.6 1.3 1 0 0 1 1 1 0 C-terminal duplication domain of Friend of PRMT1 Apis_Csd PF11671.8 ETO04091.1 - 0.0075 16.3 2.2 0.01 15.8 2.2 1.2 1 0 0 1 1 1 1 Complementary sex determiner protein HEAT_2 PF13646.6 ETO04092.1 - 7.5e-14 51.9 0.1 6.6e-13 48.9 0.0 2.0 1 1 0 2 2 2 1 HEAT repeats HEAT_PBS PF03130.16 ETO04092.1 - 2.9e-08 33.6 0.0 0.0011 19.5 0.0 3.4 4 0 0 4 4 4 2 PBS lyase HEAT-like repeat HEAT PF02985.22 ETO04092.1 - 0.00013 21.9 0.0 0.019 15.2 0.0 3.1 3 0 0 3 3 3 1 HEAT repeat TAF6_C PF07571.13 ETO04092.1 - 0.02 15.2 0.0 3 8.2 0.0 2.6 1 1 2 3 3 3 0 TAF6 C-terminal HEAT repeat domain Arm PF00514.23 ETO04092.1 - 0.091 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat Vfa1 PF08432.10 ETO04093.1 - 0.0033 17.8 4.3 0.0041 17.5 4.3 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 HemX PF04375.14 ETO04093.1 - 0.018 14.3 4.4 0.022 14.1 4.4 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Erythro_esteras PF05139.14 ETO04093.1 - 0.023 14.5 0.7 0.026 14.3 0.7 1.0 1 0 0 1 1 1 0 Erythromycin esterase Serinc PF03348.15 ETO04093.1 - 0.037 13.0 5.2 0.045 12.7 5.2 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3492 PF11997.8 ETO04093.1 - 0.043 13.6 4.7 0.048 13.4 4.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) DUF4407 PF14362.6 ETO04093.1 - 0.049 13.0 2.0 0.064 12.6 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SseC PF04888.12 ETO04093.1 - 0.051 13.2 1.9 0.056 13.0 1.9 1.0 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family TEX13 PF15186.6 ETO04093.1 - 0.061 13.0 10.6 0.084 12.6 10.6 1.1 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family ASL_C PF08328.11 ETO04093.1 - 0.066 13.3 4.1 0.089 12.9 4.1 1.2 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal DUF5349 PF17298.2 ETO04093.1 - 0.089 12.5 3.9 0.11 12.3 3.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) AI-2E_transport PF01594.16 ETO04093.1 - 0.13 11.4 0.7 0.16 11.1 0.7 1.1 1 0 0 1 1 1 0 AI-2E family transporter TMPIT PF07851.13 ETO04093.1 - 0.14 11.4 8.6 0.18 11.0 8.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein Exonuc_VII_L PF02601.15 ETO04093.1 - 0.37 10.3 4.9 0.43 10.1 4.9 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sporozoite_P67 PF05642.11 ETO04093.1 - 0.58 8.2 3.1 0.32 9.0 1.5 1.3 1 1 0 1 1 1 0 Sporozoite P67 surface antigen FlxA PF14282.6 ETO04093.1 - 4.6 7.3 18.3 2.1 8.4 10.6 2.2 1 1 1 2 2 2 0 FlxA-like protein DUF1664 PF07889.12 ETO04093.1 - 9.8 6.2 10.0 27 4.8 9.9 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) PAP_central PF04928.17 ETO04094.1 - 3.1e-07 29.6 0.0 4.3e-07 29.2 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain CCD48 PF15799.5 ETO04095.1 - 0.008 14.6 0.3 0.0086 14.4 0.3 1.0 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 AATF-Che1 PF13339.6 ETO04095.1 - 0.043 14.5 8.8 0.35 11.6 0.4 2.1 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor DUF755 PF05501.11 ETO04095.1 - 0.42 10.9 7.9 0.5 10.6 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF755) MIP-T3_C PF17749.1 ETO04095.1 - 0.49 10.4 9.0 5.5 6.9 7.5 2.6 1 1 1 2 2 2 0 Microtubule-binding protein MIP-T3 C-terminal region FKS1_dom1 PF14288.6 ETO04096.1 - 0.43 10.9 2.7 0.59 10.5 1.6 1.7 1 1 1 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Peptidase_C37 PF05416.12 ETO04098.1 - 2.1 6.8 6.4 2.5 6.5 6.4 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase Connexin PF00029.19 ETO04098.1 - 9.2 5.9 12.6 7.8 6.2 11.5 1.4 2 0 0 2 2 2 0 Connexin PAE PF03283.13 ETO04100.1 - 0.046 12.8 0.1 0.071 12.2 0.1 1.2 1 0 0 1 1 1 0 Pectinacetylesterase Chordopox_A13L PF05961.11 ETO04100.1 - 0.069 13.4 1.2 11 6.4 0.0 2.2 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Endonuc-dimeris PF09124.10 ETO04100.1 - 0.65 10.2 4.4 15 5.8 0.9 2.6 2 1 0 2 2 2 0 T4 recombination endonuclease VII, dimerisation ATF7IP_BD PF16788.5 ETO04101.1 - 0.0048 17.0 6.6 0.0076 16.4 6.6 1.2 1 0 0 1 1 1 1 ATF-interacting protein binding domain Shugoshin_N PF07558.11 ETO04101.1 - 0.0088 15.9 1.8 0.024 14.5 1.8 1.7 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region Tsc35 PF15079.6 ETO04101.1 - 0.012 15.2 4.0 0.016 14.8 4.0 1.1 1 0 0 1 1 1 0 Testis-specific protein 35 HALZ PF02183.18 ETO04101.1 - 0.013 15.7 1.6 0.16 12.2 0.1 2.2 1 1 1 2 2 2 0 Homeobox associated leucine zipper RapA_C PF12137.8 ETO04101.1 - 0.36 9.8 6.5 0.49 9.4 6.5 1.2 1 0 0 1 1 1 0 RNA polymerase recycling family C-terminal Paramyxo_ncap PF00973.19 ETO04101.1 - 0.51 9.2 6.8 0.61 8.9 6.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF3573 PF12097.8 ETO04101.1 - 0.58 8.9 2.3 0.63 8.8 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) TMF_DNA_bd PF12329.8 ETO04101.1 - 0.92 9.6 13.0 3.1 7.9 13.0 2.0 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding L_lactis_ph-MCP PF06673.11 ETO04101.1 - 0.98 8.3 4.6 1.3 8.0 4.6 1.1 1 0 0 1 1 1 0 Lactococcus lactis bacteriophage major capsid protein DUF2207 PF09972.9 ETO04103.1 - 0.065 12.0 0.0 0.1 11.3 0.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Cation_ATPase_C PF00689.21 ETO04103.1 - 0.15 11.8 3.5 0.22 11.2 3.5 1.2 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus Herpes_UL32 PF06070.11 ETO04103.1 - 0.19 9.4 0.8 0.24 9.1 0.8 1.0 1 0 0 1 1 1 0 Herpesvirus large structural phosphoprotein UL32 Vma12 PF11712.8 ETO04103.1 - 1.5 8.9 4.0 2.5 8.2 4.0 1.6 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2721 PF11026.8 ETO04103.1 - 9.6 6.1 13.6 0.32 10.9 0.8 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) Kelch_1 PF01344.25 ETO04104.1 - 1.3e-09 37.5 0.2 6.5e-05 22.4 0.0 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO04104.1 - 2.9e-06 27.4 0.1 0.0023 18.2 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO04104.1 - 2.6e-05 24.1 0.1 0.021 14.8 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO04104.1 - 8e-05 22.5 0.3 0.01 15.8 0.1 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO04104.1 - 0.00049 20.0 0.8 0.32 11.0 0.1 2.5 2 1 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO04104.1 - 0.011 16.0 0.0 1.2 9.5 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF1387 PF07139.11 ETO04105.1 - 1.2 8.8 12.7 1.6 8.4 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF1754 PF08555.10 ETO04105.1 - 3.4 8.5 22.2 0.67 10.8 8.3 2.1 1 1 1 2 2 2 0 Eukaryotic family of unknown function (DUF1754) PINIT PF14324.6 ETO04106.1 - 0.045 14.1 0.2 0.06 13.7 0.2 1.4 1 0 0 1 1 1 0 PINIT domain MTES_1575 PF18741.1 ETO04106.1 - 0.054 13.7 0.8 0.083 13.1 0.8 1.4 1 1 0 1 1 1 0 REase_MTES_1575 Sigma_1s PF02454.16 ETO04106.1 - 0.082 12.9 1.0 0.11 12.5 1.0 1.2 1 0 0 1 1 1 0 Sigma 1s protein DUF4252 PF14060.6 ETO04106.1 - 1.5 8.7 4.3 1.2 9.0 3.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4252) BioT2 PF15368.6 ETO04108.1 - 0.015 15.3 0.1 0.023 14.7 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis family BioT2 RAMP PF04901.13 ETO04108.1 - 0.027 14.5 0.1 0.068 13.2 0.0 1.6 2 0 0 2 2 2 0 Receptor activity modifying family Phage_Nu1 PF07471.12 ETO04110.1 - 0.21 11.3 0.4 0.31 10.8 0.4 1.1 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 MSP1a PF11670.8 ETO04110.1 - 2 7.7 7.1 0.087 12.1 0.8 1.7 1 1 1 2 2 2 0 Major surface protein 1a (MSP1a) YajC PF02699.15 ETO04111.1 - 0.37 10.7 0.2 0.37 10.7 0.2 2.9 3 0 0 3 3 3 0 Preprotein translocase subunit Tk-SP_N-pro PF18237.1 ETO04112.1 - 0.0036 17.3 0.0 3.8 7.6 0.0 2.6 2 0 0 2 2 2 2 Tk-SP N-propeptide domain AdenylateSensor PF16579.5 ETO04113.1 - 0.1 13.0 0.2 1.2 9.6 0.1 2.1 1 1 1 2 2 2 0 Adenylate sensor of SNF1-like protein kinase HSD3 PF15244.6 ETO04114.1 - 0.14 11.7 0.5 0.16 11.5 0.5 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 SH2 PF00017.24 ETO04116.1 - 3.5e-07 30.2 0.0 1.4e-06 28.3 0.0 1.9 1 1 0 1 1 1 1 SH2 domain Tax PF02959.16 ETO04118.1 - 0.93 8.9 9.0 0.48 9.8 6.7 1.5 1 1 0 1 1 1 0 HTLV Tax MRP-S31 PF15433.6 ETO04119.1 - 0.034 13.8 7.7 0.043 13.5 7.7 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Pox_RNA_Pol_19 PF05320.12 ETO04119.1 - 0.056 13.4 2.1 0.063 13.2 1.5 1.3 1 1 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit CENP-F_leu_zip PF10473.9 ETO04120.1 - 0.015 15.3 6.9 0.05 13.6 5.6 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 ETO04120.1 - 0.024 15.2 8.0 0.04 14.4 8.0 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region HAUS-augmin3 PF14932.6 ETO04120.1 - 0.25 10.9 11.3 0.38 10.3 11.3 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 RabGAP-TBC PF00566.18 ETO04121.1 - 6.3e-14 52.1 1.7 7.3e-14 51.9 1.7 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain SicP-binding PF09119.10 ETO04121.1 - 0.072 13.1 0.2 0.24 11.4 0.1 1.8 2 0 0 2 2 2 0 SicP binding CPV_Polyhedrin PF17515.2 ETO04122.1 - 0.0044 16.4 0.1 0.0044 16.4 0.1 1.1 1 0 0 1 1 1 1 Cypovirus polyhedrin DUF2967 PF11179.8 ETO04123.1 - 0.022 12.9 4.9 0.024 12.8 4.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) GvpH PF05455.11 ETO04123.1 - 0.17 11.9 6.0 0.19 11.8 6.0 1.0 1 0 0 1 1 1 0 GvpH RCC1_2 PF13540.6 ETO04124.1 - 2.5e-18 65.4 12.6 3.7e-07 29.8 2.2 3.3 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO04124.1 - 1.3e-12 48.1 0.1 0.0099 16.5 0.1 3.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Sema PF01403.19 ETO04124.1 - 0.052 12.4 0.3 0.066 12.0 0.3 1.2 1 0 0 1 1 1 0 Sema domain CMS1 PF14617.6 ETO04124.1 - 0.4 10.0 3.0 2.7 7.3 0.0 2.3 2 0 0 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit MatE PF01554.18 ETO04125.1 - 0.15 11.7 2.5 0.42 10.3 0.1 2.1 2 0 0 2 2 2 0 MatE PI3K_1B_p101 PF10486.9 ETO04127.1 - 0.47 8.2 6.9 0.45 8.2 6.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sporozoite_P67 PF05642.11 ETO04127.1 - 3.8 5.5 16.4 6.2 4.8 16.5 1.4 1 1 0 1 1 1 0 Sporozoite P67 surface antigen PMSI1 PF15322.6 ETO04127.1 - 7.3 5.9 16.0 4.7 6.6 10.2 2.0 1 1 1 2 2 2 0 Protein missing in infertile sperm 1, putative ORF6C PF10552.9 ETO04128.1 - 0.073 13.2 11.6 0.55 10.3 3.0 2.3 1 1 1 2 2 2 0 ORF6C domain SUR7 PF06687.12 ETO04128.1 - 0.29 10.8 0.9 0.32 10.6 0.9 1.1 1 0 0 1 1 1 0 SUR7/PalI family Upf2 PF04050.14 ETO04128.1 - 0.31 11.8 10.4 7 7.4 0.2 2.2 1 1 0 2 2 2 0 Up-frameshift suppressor 2 CNP1 PF08750.11 ETO04129.1 - 0.026 14.5 0.1 0.035 14.1 0.1 1.3 1 0 0 1 1 1 0 CNP1-like family FAM184 PF15665.5 ETO04129.1 - 0.07 12.9 12.9 0.14 11.9 1.6 2.0 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B Spc7 PF08317.11 ETO04130.1 - 0.0046 15.9 3.6 0.0046 15.9 3.6 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein ZapB PF06005.12 ETO04130.1 - 0.031 14.7 0.2 0.031 14.7 0.2 2.1 1 1 1 2 2 2 0 Cell division protein ZapB Hrs_helical PF12210.8 ETO04130.1 - 0.036 14.6 1.7 0.061 13.9 1.7 1.4 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate DivIC PF04977.15 ETO04130.1 - 0.16 11.7 4.6 0.31 10.9 0.8 2.4 1 1 1 2 2 2 0 Septum formation initiator ASD2 PF08687.11 ETO04130.1 - 0.2 11.2 7.2 0.12 11.9 5.7 1.3 1 1 0 1 1 1 0 Apx/Shroom domain ASD2 DASH_Spc19 PF08287.11 ETO04130.1 - 1.5 8.7 8.7 1.6 8.6 0.4 2.2 1 1 1 2 2 2 0 Spc19 SR-25 PF10500.9 ETO04130.1 - 4.8 6.7 15.7 1.4 8.5 12.9 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein NST1 PF13945.6 ETO04132.1 - 0.066 13.3 9.6 0.081 13.0 9.6 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator SAE2 PF08573.10 ETO04132.1 - 0.12 13.5 1.8 0.18 12.9 1.8 1.4 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus Pox_Ag35 PF03286.14 ETO04132.1 - 0.83 9.4 8.0 1 9.1 8.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Gti1_Pac2 PF09729.9 ETO04132.1 - 7.8 6.5 9.7 9.6 6.3 9.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Secretin_N_2 PF07655.13 ETO04133.1 - 0.23 12.0 20.7 0.72 10.4 4.8 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain LSM14 PF12701.7 ETO04136.1 - 0.036 14.2 0.0 0.14 12.3 0.0 1.9 2 0 0 2 2 2 0 Scd6-like Sm domain EF-hand_7 PF13499.6 ETO04137.1 - 1.2e-08 35.3 2.5 0.00021 21.7 0.1 1.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO04137.1 - 2.1e-07 30.0 0.1 3.9e-07 29.2 0.1 1.5 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO04137.1 - 3.9e-05 23.2 0.1 8.3e-05 22.2 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ETO04137.1 - 0.001 18.4 0.3 0.0018 17.7 0.3 1.4 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 ETO04137.1 - 0.0012 18.6 0.1 0.002 18.0 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO04137.1 - 0.094 13.0 1.0 0.29 11.5 1.0 1.8 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region tRNA_synt_1c_R2 PF04557.15 ETO04137.1 - 0.15 13.0 4.0 0.27 12.2 3.2 1.7 1 1 1 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Nsp1_C PF05064.13 ETO04138.1 - 0.0019 18.0 0.3 0.015 15.1 0.1 2.5 1 1 2 3 3 3 1 Nsp1-like C-terminal region LtuB PF17455.2 ETO04138.1 - 0.08 13.6 0.2 0.17 12.5 0.2 1.5 1 0 0 1 1 1 0 Late transcription unit B DUF1651 PF07864.11 ETO04139.1 - 0.18 12.2 1.4 1.9 8.9 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1651) MIT PF04212.18 ETO04140.1 - 7.4e-13 48.4 0.7 7.4e-13 48.4 0.7 1.7 2 1 0 2 2 2 1 MIT (microtubule interacting and transport) domain RGS PF00615.19 ETO04141.1 - 0.014 15.6 1.3 0.027 14.7 1.3 1.7 1 1 0 1 1 1 0 Regulator of G protein signaling domain Rav1p_C PF12234.8 ETO04142.1 - 0.028 12.8 0.5 0.034 12.6 0.5 1.0 1 0 0 1 1 1 0 RAVE protein 1 C terminal FCP1_C PF09309.10 ETO04143.1 - 0.49 10.2 7.7 0.51 10.2 7.7 1.0 1 0 0 1 1 1 0 FCP1, C-terminal THF_DHG_CYH_C PF02882.19 ETO04144.1 - 2.9e-28 98.2 0.1 1.1e-26 93.1 0.1 2.0 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 ETO04144.1 - 0.022 14.8 0.0 0.037 14.1 0.0 1.4 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Guanylate_cyc_2 PF09778.9 ETO04144.1 - 0.037 13.4 0.0 0.046 13.1 0.0 1.1 1 0 0 1 1 1 0 Guanylylate cyclase Chordopox_G3 PF06129.12 ETO04144.1 - 0.083 13.6 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 Chordopoxvirus G3 protein AlaDh_PNT_C PF01262.21 ETO04144.1 - 0.098 11.9 0.1 0.13 11.5 0.1 1.3 1 1 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DEAD PF00270.29 ETO04145.1 - 0.00018 21.4 0.0 0.00037 20.3 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF1631 PF07793.11 ETO04145.1 - 0.014 13.9 0.1 0.017 13.6 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) B56 PF01603.20 ETO04148.1 - 1e-64 219.1 3.7 1.1e-64 219.0 3.7 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) WavE PF07507.11 ETO04150.1 - 0.021 14.0 0.2 0.023 13.9 0.2 1.1 1 0 0 1 1 1 0 WavE lipopolysaccharide synthesis DUF2818 PF10993.8 ETO04150.1 - 0.071 13.7 0.1 0.096 13.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2818) AAA_16 PF13191.6 ETO04151.1 - 3.2e-06 27.6 0.0 4.1e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain dNK PF01712.19 ETO04151.1 - 0.0055 16.6 0.3 0.01 15.7 0.1 1.8 2 1 0 2 2 2 1 Deoxynucleoside kinase NB-ARC PF00931.22 ETO04151.1 - 0.011 14.9 0.1 0.016 14.4 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain DAP3 PF10236.9 ETO04151.1 - 0.012 14.8 0.0 0.023 13.9 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_22 PF13401.6 ETO04151.1 - 0.028 14.7 0.0 0.14 12.4 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO04151.1 - 0.077 13.5 0.9 0.11 13.0 0.0 1.8 3 0 0 3 3 3 0 AAA domain ATPase_2 PF01637.18 ETO04151.1 - 0.079 12.9 0.0 0.22 11.4 0.0 1.7 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_PrkA PF08298.11 ETO04151.1 - 0.1 11.5 0.0 0.1 11.5 0.0 1.1 1 0 0 1 1 1 0 PrkA AAA domain Peptidase_M3_N PF08439.10 ETO04151.1 - 0.16 12.3 0.4 0.46 10.8 0.4 1.8 1 0 0 1 1 1 0 Oligopeptidase F G-alpha PF00503.20 ETO04154.1 - 3.6e-07 29.7 0.5 4.3e-07 29.4 0.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit NOD2_WH PF17779.1 ETO04154.1 - 0.052 13.9 0.2 0.087 13.2 0.2 1.5 1 0 0 1 1 1 0 NOD2 winged helix domain TLC PF03219.14 ETO04154.1 - 0.16 10.7 0.0 0.17 10.5 0.0 1.0 1 0 0 1 1 1 0 TLC ATP/ADP transporter TipE PF16972.5 ETO04155.1 - 0.029 13.6 0.1 0.036 13.3 0.1 1.1 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE DUF2383 PF09537.10 ETO04156.1 - 0.021 15.2 3.6 0.021 15.2 3.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF2383) RNA_pol_L_2 PF13656.6 ETO04156.1 - 0.027 14.2 1.4 0.046 13.5 1.4 1.6 1 1 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Peptidase_M32 PF02074.15 ETO04156.1 - 0.29 9.8 12.9 0.37 9.5 12.9 1.1 1 0 0 1 1 1 0 Carboxypeptidase Taq (M32) metallopeptidase CorA PF01544.18 ETO04156.1 - 1.3 8.3 15.4 1.1 8.5 14.2 1.5 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DNA_pol_B_exo1 PF03104.19 ETO04158.1 - 1.1e-32 113.5 0.0 1.4e-32 113.2 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_exo2 PF10108.9 ETO04158.1 - 5.4e-09 36.0 0.8 9.9e-08 31.9 0.8 2.1 1 1 0 1 1 1 1 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB RNase_H_2 PF13482.6 ETO04158.1 - 0.00017 21.6 0.8 0.0018 18.3 0.8 2.5 1 1 0 1 1 1 1 RNase_H superfamily UCH PF00443.29 ETO04162.1 - 4.3e-31 108.4 0.1 5e-31 108.1 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Adhesin_P1_N PF18652.1 ETO04163.1 - 0.19 11.8 2.5 0.37 10.8 2.5 1.5 1 0 0 1 1 1 0 Adhesin P1 N-terminal domain Hydrolase PF00702.26 ETO04164.1 - 1.6e-07 31.9 0.1 2.3e-07 31.3 0.1 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF1015 PF06245.11 ETO04167.1 - 1.8e-43 148.9 0.0 2.3e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1015) HALZ PF02183.18 ETO04168.1 - 0.004 17.3 4.6 0.11 12.8 0.0 2.9 3 0 0 3 3 3 1 Homeobox associated leucine zipper YabA PF06156.13 ETO04168.1 - 0.0069 17.0 10.2 0.027 15.1 0.1 2.2 2 0 0 2 2 2 1 Initiation control protein YabA ZapB PF06005.12 ETO04168.1 - 0.018 15.5 20.1 0.59 10.6 0.5 3.0 2 1 0 2 2 2 0 Cell division protein ZapB Tropomyosin_1 PF12718.7 ETO04168.1 - 0.021 15.0 11.1 0.021 15.0 11.1 2.0 2 0 0 2 2 2 0 Tropomyosin like bZIP_1 PF00170.21 ETO04168.1 - 0.038 14.1 11.5 0.046 13.8 0.1 3.2 3 0 0 3 3 3 0 bZIP transcription factor GAS PF13851.6 ETO04168.1 - 0.18 11.1 15.0 0.32 10.3 13.2 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding LMBR1 PF04791.16 ETO04168.1 - 0.18 10.7 4.4 0.22 10.4 4.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein HAP1_N PF04849.13 ETO04168.1 - 0.19 10.9 13.3 0.75 8.9 12.3 1.9 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DUF1539 PF07560.11 ETO04168.1 - 0.28 11.3 6.9 3.7 7.6 0.1 2.1 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) APG6_N PF17675.1 ETO04168.1 - 0.32 11.5 22.2 1.9 9.0 17.1 2.2 1 1 0 2 2 2 0 Apg6 coiled-coil region TMF_DNA_bd PF12329.8 ETO04168.1 - 0.51 10.4 19.6 1.8 8.6 0.3 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 ETO04168.1 - 0.86 9.6 16.7 1.3 9.1 0.2 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KASH_CCD PF14662.6 ETO04168.1 - 1 9.2 16.4 1.9 8.3 0.6 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TRAF_BIRC3_bd PF16673.5 ETO04168.1 - 1.2 9.0 6.2 2.1 8.2 1.2 3.0 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Jnk-SapK_ap_N PF09744.9 ETO04168.1 - 1.5 9.1 16.9 10 6.3 11.2 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4094 PF13334.6 ETO04168.1 - 2 8.9 6.3 11 6.6 1.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) GIT_CC PF16559.5 ETO04168.1 - 2 8.3 10.6 6.1 6.8 0.1 3.1 3 0 0 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor bZIP_2 PF07716.15 ETO04168.1 - 3.5 7.8 14.8 4.7 7.4 0.0 3.4 3 0 0 3 3 3 0 Basic region leucine zipper CENP-H PF05837.12 ETO04168.1 - 3.8 8.0 15.8 0.96 9.9 0.2 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ERM PF00769.19 ETO04168.1 - 8.3 6.1 19.5 70 3.1 18.8 1.9 1 1 0 1 1 1 0 Ezrin/radixin/moesin family PIN_12 PF16289.5 ETO04169.1 - 0.00021 21.8 0.1 0.00023 21.7 0.1 1.1 1 0 0 1 1 1 1 PIN domain Macro PF01661.21 ETO04170.1 - 1.4e-11 44.5 0.0 2.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Macro domain FYRN PF05964.14 ETO04171.1 - 2.8e-13 49.5 0.1 5.5e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus Pkinase PF00069.25 ETO04172.1 - 0.00044 19.7 0.0 0.00058 19.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain FoP_duplication PF13865.6 ETO04174.1 - 3.2 8.3 15.4 0.34 11.5 7.2 2.4 2 1 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 TFIIF_alpha PF05793.12 ETO04174.1 - 5.3 5.5 24.6 5.8 5.4 24.6 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) sCache_like PF16736.5 ETO04175.1 - 0.037 14.1 0.1 0.043 13.9 0.1 1.1 1 0 0 1 1 1 0 Single Cache-like ResIII PF04851.15 ETO04175.1 - 0.053 13.5 0.5 0.082 12.9 0.3 1.3 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit DUF3246 PF11596.8 ETO04176.1 - 0.011 15.1 7.6 0.016 14.6 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) BK_channel_a PF03493.18 ETO04176.1 - 0.76 10.0 6.9 3 8.1 0.1 2.3 1 1 1 2 2 2 0 Calcium-activated BK potassium channel alpha subunit AA_permease PF00324.21 ETO04177.1 - 1.6e-15 56.7 16.3 1.9e-15 56.4 16.3 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETO04177.1 - 0.014 14.3 14.1 0.041 12.7 14.3 1.5 1 1 1 2 2 2 0 Amino acid permease DUF2207 PF09972.9 ETO04177.1 - 0.073 11.8 4.0 0.085 11.6 4.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DHHC PF01529.20 ETO04177.1 - 0.41 10.8 2.8 0.99 9.5 0.9 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF3671 PF12420.8 ETO04177.1 - 0.54 10.4 6.6 1.4 9.1 6.6 1.9 1 1 0 1 1 1 0 Protein of unknown function AAA_6 PF12774.7 ETO04178.1 - 2.8e-61 207.3 0.2 3.5e-61 207.0 0.2 1.1 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region RsgA_GTPase PF03193.16 ETO04178.1 - 0.0045 16.9 0.1 0.0068 16.3 0.1 1.2 1 0 0 1 1 1 1 RsgA GTPase T2SSE PF00437.20 ETO04178.1 - 0.016 14.3 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_7 PF12775.7 ETO04178.1 - 0.023 14.2 0.1 0.043 13.3 0.1 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Virul_Fac PF10139.9 ETO04178.1 - 0.047 11.9 0.0 0.061 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor AAA_22 PF13401.6 ETO04178.1 - 0.093 13.0 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO04178.1 - 0.1 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain cNMP_binding PF00027.29 ETO04180.1 - 1.6e-15 56.9 0.0 2.8e-15 56.2 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain YceD PF02620.17 ETO04181.1 - 0.03 14.4 7.9 0.12 12.5 7.5 2.2 1 1 0 1 1 1 0 Large ribosomal RNA subunit accumulation protein YceD DUF1387 PF07139.11 ETO04181.1 - 0.86 9.3 23.7 1 9.0 23.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4551 PF15087.6 ETO04181.1 - 1.8 7.3 14.0 2.2 7.0 14.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF1754 PF08555.10 ETO04181.1 - 5.2 7.9 27.8 0.36 11.7 15.0 2.3 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) PPR_2 PF13041.6 ETO04182.1 - 1.7e-09 37.7 0.0 0.00021 21.4 0.0 3.0 3 0 0 3 3 3 2 PPR repeat family PPR_long PF17177.4 ETO04182.1 - 7.5e-06 25.4 0.0 8.4e-06 25.3 0.0 1.0 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ETO04182.1 - 8.2e-05 22.6 1.7 0.81 10.1 0.1 3.2 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 ETO04182.1 - 0.00021 21.3 0.0 0.0025 17.8 0.0 2.1 2 0 0 2 2 2 1 Pentatricopeptide repeat domain Rhabdo_NV PF02484.15 ETO04182.1 - 0.13 12.4 0.0 0.16 12.1 0.0 1.2 1 0 0 1 1 1 0 Rhabdovirus Non-virion protein Brix PF04427.18 ETO04183.1 - 0.0091 16.1 0.8 0.044 13.9 0.0 2.1 2 1 0 2 2 2 1 Brix domain DUF188 PF02639.14 ETO04183.1 - 0.015 14.9 1.4 2 8.1 0.0 2.4 2 1 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Lipase_GDSL_3 PF14606.6 ETO04183.1 - 0.11 12.6 0.9 0.18 11.9 0.9 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Popeye PF04831.13 ETO04184.1 - 4.4e-12 46.4 0.1 4.8e-12 46.2 0.1 1.2 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 ETO04184.1 - 0.03 14.4 0.0 0.049 13.7 0.0 1.4 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain RPOL_N PF14700.6 ETO04185.1 - 0.0069 15.8 0.7 0.0072 15.8 0.7 1.0 1 0 0 1 1 1 1 DNA-directed RNA polymerase N-terminal Imm-NTF2 PF15655.6 ETO04185.1 - 0.013 15.7 0.4 0.018 15.3 0.4 1.1 1 0 0 1 1 1 0 NTF2 fold immunity protein ANAPC_CDC26 PF10471.9 ETO04185.1 - 0.045 14.6 3.9 1.6 9.6 0.7 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Menin PF05053.13 ETO04185.1 - 0.16 10.3 5.3 0.15 10.4 5.3 1.0 1 0 0 1 1 1 0 Menin Ank_2 PF12796.7 ETO04186.1 - 4.5e-16 59.2 0.5 2.2e-07 31.3 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO04186.1 - 2.4e-15 56.2 0.2 6.4e-05 23.2 0.1 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_4 PF13637.6 ETO04186.1 - 1.4e-14 54.2 0.6 6.3e-06 26.6 0.0 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO04186.1 - 8.4e-14 50.3 0.2 1.3e-05 25.1 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ETO04186.1 - 1.4e-12 47.5 0.1 2e-06 28.0 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) PUF PF00806.19 ETO04186.1 - 0.056 13.2 0.0 0.83 9.5 0.0 2.4 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat RhoGAP PF00620.27 ETO04187.1 - 3.1e-15 56.3 0.0 4.7e-15 55.7 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Xin PF08043.12 ETO04187.1 - 0.86 9.3 3.8 0.93 9.2 2.5 1.7 2 0 0 2 2 2 0 Xin repeat DEP PF00610.21 ETO04188.1 - 1.8e-12 47.2 0.1 2.6e-12 46.6 0.1 1.3 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) SICA_beta PF12878.7 ETO04188.1 - 0.023 14.9 0.3 0.028 14.6 0.3 1.1 1 0 0 1 1 1 0 SICA extracellular beta domain Mad3_BUB1_I PF08311.12 ETO04191.1 - 0.00017 21.6 1.3 0.00017 21.6 1.3 1.8 2 1 0 2 2 2 1 Mad3/BUB1 homology region 1 Cas_Cas02710 PF09670.10 ETO04191.1 - 0.023 13.5 1.3 0.029 13.2 1.3 1.1 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas02710) SYCE1 PF15233.6 ETO04191.1 - 0.075 13.1 3.7 0.078 13.0 2.8 1.4 1 1 0 1 1 1 0 Synaptonemal complex central element protein 1 Apc15p PF05841.11 ETO04192.1 - 0.015 16.1 2.0 0.017 16.0 2.0 1.1 1 0 0 1 1 1 0 Apc15p protein Orf78 PF06024.12 ETO04192.1 - 0.29 11.4 2.7 0.32 11.3 2.7 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Gti1_Pac2 PF09729.9 ETO04193.1 - 9.3 6.3 12.8 3.9 7.5 10.4 1.6 1 1 1 2 2 2 0 Gti1/Pac2 family UQ_con PF00179.26 ETO04195.1 - 1.7e-14 53.6 0.2 1.7e-14 53.6 0.2 2.0 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Caskin-tail PF16632.5 ETO04195.1 - 0.13 12.7 0.1 0.23 11.9 0.1 1.4 1 0 0 1 1 1 0 C-terminal region of Caskin SDA1 PF05285.12 ETO04196.1 - 0.011 15.2 24.0 0.013 14.9 24.0 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO04196.1 - 0.027 12.8 18.8 0.03 12.6 18.8 1.0 1 0 0 1 1 1 0 CDC45-like protein PAF PF15715.5 ETO04196.1 - 0.041 14.5 7.4 0.053 14.1 7.4 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain RNA_pol_Rpc4 PF05132.14 ETO04196.1 - 0.096 13.1 4.6 0.11 12.9 4.6 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 SURF2 PF05477.11 ETO04196.1 - 0.1 12.2 7.1 0.12 12.0 7.1 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) CobT PF06213.12 ETO04196.1 - 0.11 11.9 18.0 0.12 11.7 18.0 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 ETO04196.1 - 0.12 10.4 26.6 0.13 10.3 26.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO04196.1 - 0.14 10.3 23.0 0.15 10.2 23.0 1.0 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 ETO04196.1 - 0.35 10.7 8.6 0.4 10.5 8.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sigma70_ner PF04546.13 ETO04196.1 - 0.39 10.6 17.6 0.51 10.2 17.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region ALMT PF11744.8 ETO04196.1 - 0.6 8.9 2.1 0.65 8.8 2.1 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter BUD22 PF09073.10 ETO04196.1 - 0.73 9.1 17.5 0.79 9.0 17.5 1.1 1 0 0 1 1 1 0 BUD22 SAPS PF04499.15 ETO04196.1 - 1.1 7.9 11.3 1.2 7.8 11.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein YL1 PF05764.13 ETO04196.1 - 2.4 8.2 22.4 2.9 8.0 22.4 1.1 1 0 0 1 1 1 0 YL1 nuclear protein TRAP_alpha PF03896.16 ETO04196.1 - 2.9 7.0 12.6 3.5 6.8 12.6 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit LAP1C PF05609.12 ETO04196.1 - 4 6.4 11.5 4.7 6.2 11.5 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 ETO04196.1 - 4.9 5.8 6.9 5.3 5.7 6.9 1.1 1 0 0 1 1 1 0 Presenilin Kelch_1 PF01344.25 ETO04198.1 - 7.1e-07 28.7 2.6 0.00015 21.3 0.9 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO04198.1 - 9e-05 22.4 6.0 0.12 12.4 0.9 3.7 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO04198.1 - 0.00035 20.7 0.9 0.15 12.4 0.3 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO04198.1 - 0.019 14.9 1.7 5.7 7.1 0.1 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO04198.1 - 0.038 14.0 0.1 0.038 14.0 0.1 2.5 3 0 0 3 3 3 0 Galactose oxidase, central domain TetR_C_22 PF17928.1 ETO04199.1 - 0.0036 17.6 0.1 0.52 10.6 0.0 2.1 2 0 0 2 2 2 2 Tetracyclin repressor-like, C-terminal domain DUF2968 PF11180.8 ETO04199.1 - 0.0045 16.7 0.4 0.0079 15.8 0.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2968) TRF PF08558.10 ETO04199.1 - 0.043 13.4 0.3 0.25 10.9 0.0 1.9 1 1 1 2 2 2 0 Telomere repeat binding factor (TRF) ALIX_LYPXL_bnd PF13949.6 ETO04201.1 - 0.0037 16.6 12.1 0.0065 15.8 12.1 1.5 1 1 0 1 1 1 1 ALIX V-shaped domain binding to HIV DUF1843 PF08898.10 ETO04201.1 - 0.017 15.6 4.2 0.051 14.1 0.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) GvpK PF05121.12 ETO04201.1 - 0.023 14.7 5.6 0.17 11.9 0.5 2.6 1 1 2 3 3 3 0 Gas vesicle protein K ABC_tran_CTD PF16326.5 ETO04201.1 - 0.031 14.5 2.6 0.031 14.5 2.6 2.6 1 1 1 2 2 2 0 ABC transporter C-terminal domain DUF1476 PF07345.11 ETO04201.1 - 0.048 14.0 0.6 7.8 6.9 0.1 2.2 2 0 0 2 2 2 0 ATPase inhibitor subunit zeta PSRP-3_Ycf65 PF04839.13 ETO04201.1 - 0.097 12.9 0.1 0.32 11.3 0.1 1.8 1 0 0 1 1 1 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) Cep57_MT_bd PF06657.13 ETO04201.1 - 0.098 13.1 8.9 1.3 9.6 3.1 2.7 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4164 PF13747.6 ETO04201.1 - 0.16 12.3 4.1 0.25 11.6 1.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) T2SSM PF04612.12 ETO04201.1 - 0.18 11.9 0.4 0.48 10.5 0.3 1.8 1 1 1 2 2 2 0 Type II secretion system (T2SS), protein M Spc7 PF08317.11 ETO04201.1 - 0.22 10.4 16.6 0.27 10.0 16.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein LPP PF04728.13 ETO04201.1 - 0.28 11.6 3.6 0.36 11.2 0.2 2.6 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Occludin_ELL PF07303.13 ETO04201.1 - 0.28 11.9 11.6 0.096 13.4 4.9 2.4 1 1 1 2 2 2 0 Occludin homology domain DUF3450 PF11932.8 ETO04201.1 - 0.42 9.9 7.3 0.29 10.4 5.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Exonuc_VII_L PF02601.15 ETO04201.1 - 0.51 9.9 9.0 0.62 9.6 9.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DASH_Dad3 PF08656.10 ETO04201.1 - 0.58 10.3 9.0 0.87 9.7 1.3 2.7 1 1 1 2 2 2 0 DASH complex subunit Dad3 DUF1664 PF07889.12 ETO04201.1 - 0.81 9.7 9.7 0.15 12.1 4.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YkyA PF10368.9 ETO04201.1 - 0.9 9.2 20.0 2.1 8.0 19.1 1.8 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein BLOC1_2 PF10046.9 ETO04201.1 - 0.96 9.8 13.3 0.21 11.9 7.6 2.3 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4200 PF13863.6 ETO04201.1 - 1.3 9.4 17.9 0.033 14.6 7.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Jnk-SapK_ap_N PF09744.9 ETO04201.1 - 1.8 8.7 19.2 2.7 8.2 6.6 2.4 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 PRKG1_interact PF15898.5 ETO04201.1 - 3 8.8 16.5 0.82 10.6 8.0 2.4 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Fzo_mitofusin PF04799.13 ETO04201.1 - 5.5 6.5 11.8 0.37 10.3 3.8 2.4 1 1 2 3 3 3 0 fzo-like conserved region YabA PF06156.13 ETO04201.1 - 5.8 7.6 15.1 1 10.0 6.6 2.2 1 1 1 2 2 2 0 Initiation control protein YabA CLPTM1 PF05602.12 ETO04202.1 - 5.5e-87 292.5 17.8 6.5e-87 292.3 17.8 1.0 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) Pico_P2B PF01552.17 ETO04202.1 - 0.025 14.7 0.4 0.092 12.9 0.4 2.0 1 0 0 1 1 1 0 Picornavirus 2B protein PQ-loop PF04193.14 ETO04202.1 - 1.4 8.7 9.6 2.5 8.0 0.3 3.9 3 1 1 4 4 4 0 PQ loop repeat cNMP_binding PF00027.29 ETO04203.1 - 4.2e-28 97.2 0.3 3.3e-08 33.5 0.0 4.3 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain FAM176 PF14851.6 ETO04203.1 - 3.1 7.5 10.6 1.8 8.2 3.5 2.4 2 0 0 2 2 2 0 FAM176 family 2OG-FeII_Oxy_2 PF13532.6 ETO04204.1 - 2e-10 41.2 0.0 6.5e-10 39.5 0.0 1.8 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Arteri_nucleo PF01481.16 ETO04204.1 - 2.2 8.6 4.7 1.2 9.5 0.4 2.2 1 1 1 2 2 2 0 Arterivirus nucleocapsid protein HSP70 PF00012.20 ETO04205.1 - 5.7e-46 156.9 0.0 7.2e-46 156.6 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Trans_coact PF16805.5 ETO04205.1 - 1.1 9.4 5.1 3.2 7.9 0.9 2.9 3 0 0 3 3 3 0 Phage late-transcription coactivator Fib_alpha PF08702.10 ETO04206.1 - 0.028 14.6 1.9 0.11 12.7 0.0 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Spectrin PF00435.21 ETO04206.1 - 0.072 13.6 6.2 10 6.7 2.4 3.3 1 1 0 2 2 2 0 Spectrin repeat BLOC1_2 PF10046.9 ETO04206.1 - 0.076 13.3 1.6 2.2 8.6 0.1 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF2433 PF10360.9 ETO04206.1 - 0.13 12.4 2.4 3.1 7.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) DUF948 PF06103.11 ETO04206.1 - 0.17 12.2 0.2 5.5 7.3 0.1 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Syntaxin-6_N PF09177.11 ETO04206.1 - 0.44 11.1 3.2 0.61 10.7 0.4 2.4 1 1 0 2 2 2 0 Syntaxin 6, N-terminal CAP_GLY PF01302.25 ETO04207.1 - 1.2e-08 34.9 0.0 2.2e-08 34.0 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain DUF1033 PF06279.11 ETO04207.1 - 0.043 14.0 0.1 0.096 12.9 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1033) Menin PF05053.13 ETO04207.1 - 2.3 6.5 17.0 3.4 5.9 17.0 1.3 1 0 0 1 1 1 0 Menin SOG2 PF10428.9 ETO04207.1 - 4.1 6.5 16.9 6.4 5.8 16.9 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein SOBP PF15279.6 ETO04207.1 - 8.8 6.8 12.5 11 6.6 12.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Ndc1_Nup PF09531.10 ETO04207.1 - 9.5 4.8 5.8 11 4.6 5.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SAM_KSR1 PF13543.6 ETO04209.1 - 0.013 15.6 0.3 0.02 15.0 0.3 1.2 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 SAM_1 PF00536.30 ETO04209.1 - 0.12 12.8 0.1 0.19 12.2 0.1 1.4 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) Syntaxin_2 PF14523.6 ETO04212.1 - 0.0092 16.3 6.0 1.4 9.3 1.7 2.8 2 0 0 2 2 2 2 Syntaxin-like protein Totivirus_coat PF05518.11 ETO04213.1 - 0.17 9.9 0.5 0.17 9.9 0.5 1.0 1 0 0 1 1 1 0 Totivirus coat protein FapA PF03961.13 ETO04214.1 - 0.0091 14.6 9.7 0.01 14.5 9.7 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A Sigma70_ner PF04546.13 ETO04214.1 - 0.028 14.3 5.1 0.044 13.7 5.1 1.5 1 1 0 1 1 1 0 Sigma-70, non-essential region TPR_MLP1_2 PF07926.12 ETO04214.1 - 0.042 13.9 5.3 0.061 13.4 5.3 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Mod_r PF07200.13 ETO04214.1 - 0.072 13.2 7.3 0.027 14.6 4.9 1.6 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2408 PF10303.9 ETO04214.1 - 0.09 13.3 4.3 0.12 13.0 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF16 PF01519.16 ETO04214.1 - 0.16 12.5 6.3 0.27 11.8 6.2 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 Osmo_CC PF08946.10 ETO04214.1 - 0.18 12.1 4.0 0.39 11.0 3.9 1.7 1 1 0 1 1 1 0 Osmosensory transporter coiled coil K-box PF01486.17 ETO04214.1 - 0.2 11.9 5.7 1.8 8.8 5.7 2.2 1 1 0 1 1 1 0 K-box region CENP-H PF05837.12 ETO04214.1 - 0.28 11.6 4.8 0.22 12.0 3.0 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Mucin PF01456.17 ETO04214.1 - 0.38 10.8 14.3 0.59 10.1 14.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein HAUS6_N PF14661.6 ETO04214.1 - 0.42 10.2 5.2 0.56 9.8 5.2 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus ABC_tran_CTD PF16326.5 ETO04214.1 - 0.51 10.6 5.3 0.14 12.4 2.0 1.8 2 0 0 2 2 2 0 ABC transporter C-terminal domain Troponin PF00992.20 ETO04214.1 - 0.58 10.5 9.3 1.1 9.6 9.3 1.6 1 1 0 1 1 1 0 Troponin ETC_C1_NDUFA5 PF04716.14 ETO04214.1 - 2.2 8.2 7.4 0.25 11.2 0.5 2.7 3 1 0 3 3 3 0 ETC complex I subunit conserved region bZIP_1 PF00170.21 ETO04214.1 - 3.8 7.7 7.7 2.7 8.1 3.6 2.3 1 1 1 2 2 2 0 bZIP transcription factor E3_UbLigase_RBR PF18091.1 ETO04215.1 - 0.022 14.9 1.6 0.034 14.3 1.6 1.4 1 1 0 1 1 1 0 E3 Ubiquitin Ligase RBR C-terminal domain DUF190 PF02641.15 ETO04215.1 - 0.025 14.9 1.5 0.034 14.5 1.4 1.5 1 1 0 1 1 1 0 Uncharacterized ACR, COG1993 SCVP PF17619.2 ETO04215.1 - 0.028 15.2 0.4 0.032 15.1 0.4 1.2 1 0 0 1 1 1 0 Secreted clade V proteins DHHA1 PF02272.19 ETO04215.1 - 0.11 12.9 0.8 0.12 12.8 0.8 1.1 1 0 0 1 1 1 0 DHHA1 domain WD40 PF00400.32 ETO04219.1 - 1.7e-40 136.2 11.2 2e-09 37.9 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO04219.1 - 1.3e-10 40.8 0.2 0.025 13.6 0.0 4.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO04219.1 - 8.8e-08 32.4 0.1 1.4 9.3 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04219.1 - 2.7e-07 29.6 1.5 0.32 9.6 0.0 3.9 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO04219.1 - 9.1e-06 25.2 0.4 0.019 14.3 0.1 2.8 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO04219.1 - 9.6e-05 22.2 8.8 0.46 10.5 0.1 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO04219.1 - 0.00011 21.6 1.3 0.29 10.4 0.0 3.1 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO04219.1 - 0.00072 19.6 1.0 1.3 9.1 0.0 3.6 1 1 3 4 4 4 1 Family of unknown function (DUF5570) POLO_box PF00659.18 ETO04219.1 - 0.0039 17.3 0.7 5.2 7.3 0.0 3.6 4 0 0 4 4 4 1 POLO box duplicated region Pectate_lyase22 PF14583.6 ETO04219.1 - 0.024 13.3 0.0 1.2 7.7 0.0 2.0 1 1 1 2 2 2 0 Oligogalacturonate lyase Ubiquitin_3 PF14836.6 ETO04219.1 - 0.14 12.1 0.0 4.9 7.2 0.0 2.8 2 1 1 3 3 3 0 Ubiquitin-like domain AcetylCoA_hyd_C PF13336.6 ETO04219.1 - 0.15 12.0 0.0 0.97 9.4 0.0 2.0 2 0 0 2 2 2 0 Acetyl-CoA hydrolase/transferase C-terminal domain ADP_ribosyl_GH PF03747.14 ETO04220.1 - 3.4e-57 194.4 0.0 4.8e-57 193.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Sld7_N PF18636.1 ETO04221.1 - 0.015 15.7 0.6 0.02 15.3 0.6 1.2 1 0 0 1 1 1 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain Bac_rhamnosid6H PF17389.2 ETO04221.1 - 0.079 12.2 0.3 0.08 12.2 0.3 1.1 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Pro_isomerase PF00160.21 ETO04222.1 - 4.3e-54 183.1 0.4 4.9e-54 182.9 0.4 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD U-box PF04564.15 ETO04223.1 - 1.3e-14 54.1 1.0 2.8e-14 53.1 0.1 2.0 2 0 0 2 2 2 1 U-box domain zf-NOSIP PF15906.5 ETO04223.1 - 0.066 13.4 0.0 0.22 11.7 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein ATP-synt_ab_C PF00306.27 ETO04223.1 - 1.2 9.4 9.8 0.17 12.2 1.2 2.6 1 1 1 2 2 2 0 ATP synthase alpha/beta chain, C terminal domain Cbl_N2 PF02761.14 ETO04223.1 - 4.8 8.0 11.5 0.53 11.0 2.8 3.1 3 2 0 3 3 3 0 CBL proto-oncogene N-terminus, EF hand-like domain WD40 PF00400.32 ETO04224.1 - 0.037 14.9 0.1 0.099 13.5 0.0 1.8 2 0 0 2 2 2 0 WD domain, G-beta repeat DUF917 PF06032.12 ETO04224.1 - 0.088 11.6 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF917) DUF3911 PF13050.6 ETO04224.1 - 3.5 7.8 5.5 12 6.1 0.2 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3911) Ntox50 PF15542.6 ETO04224.1 - 9.7 7.1 11.1 0.75 10.6 0.5 2.6 2 1 0 2 2 2 0 Bacterial toxin 50 GvpH PF05455.11 ETO04225.1 - 0.044 13.9 0.0 0.053 13.6 0.0 1.1 1 0 0 1 1 1 0 GvpH Slu7 PF11708.8 ETO04226.1 - 0.0071 16.1 7.6 0.0084 15.9 7.6 1.1 1 0 0 1 1 1 1 Pre-mRNA splicing Prp18-interacting factor Presenilin PF01080.17 ETO04226.1 - 1.9 7.2 5.1 1.8 7.2 5.1 1.2 1 0 0 1 1 1 0 Presenilin SprA-related PF12118.8 ETO04226.1 - 2 7.5 9.8 2.5 7.2 9.8 1.1 1 0 0 1 1 1 0 SprA-related family FAM91_C PF14648.6 ETO04226.1 - 4 6.2 9.5 4.2 6.1 9.5 1.0 1 0 0 1 1 1 0 FAM91 C-terminus HSP90 PF00183.18 ETO04227.1 - 4e-62 210.8 6.8 5.3e-62 210.4 6.8 1.0 1 0 0 1 1 1 1 Hsp90 protein Y_phosphatase3 PF13350.6 ETO04228.1 - 0.0013 18.8 0.3 0.003 17.6 0.0 1.7 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ETO04228.1 - 0.0061 16.1 0.0 0.013 15.1 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase ColG_sub PF18496.1 ETO04229.1 - 0.46 10.6 9.6 1.7 8.8 2.8 3.5 3 1 1 4 4 4 0 Collagenase G catalytic helper subdomain DUF3417 PF11897.8 ETO04229.1 - 10 6.7 10.2 0.75 10.3 0.2 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF3417) WD40 PF00400.32 ETO04230.1 - 5.8e-36 121.9 18.7 2.6e-06 28.0 0.7 7.5 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04230.1 - 1.4e-10 41.4 0.4 0.032 14.5 0.0 5.5 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04230.1 - 1.8e-08 33.5 2.3 0.059 12.0 0.1 4.0 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO04230.1 - 4.5e-06 26.2 6.9 0.008 15.5 0.5 4.4 2 2 3 5 5 5 3 WD40-like domain DUF4221 PF13970.6 ETO04230.1 - 0.015 14.8 5.4 0.016 14.8 0.8 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4221) Kelch_6 PF13964.6 ETO04230.1 - 4.5 7.7 8.2 6.3 7.3 0.1 4.3 5 1 0 5 5 5 0 Kelch motif Kelch_5 PF13854.6 ETO04231.1 - 3.6e-07 30.0 9.1 0.00013 21.8 1.0 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 ETO04231.1 - 5.3e-07 29.7 4.9 0.076 13.3 0.2 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO04231.1 - 8.9e-07 28.4 3.0 0.0019 17.8 0.2 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO04231.1 - 1.4e-06 28.4 0.1 3.6e-05 23.9 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO04231.1 - 0.0032 17.5 2.4 0.029 14.4 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Phage_Integr_2 PF13009.6 ETO04233.1 - 0.016 14.3 0.2 0.021 13.9 0.2 1.1 1 0 0 1 1 1 0 Putative phage integrase zf-RING_2 PF13639.6 ETO04234.1 - 1.1e-10 41.7 5.1 2.6e-10 40.4 5.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO04234.1 - 6.6e-08 32.3 5.2 2e-07 30.7 5.2 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO04234.1 - 6.9e-08 32.7 4.3 2.2e-07 31.0 4.3 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO04234.1 - 2.5e-05 24.0 4.9 6.5e-05 22.7 4.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO04234.1 - 3.1e-05 23.8 4.7 6.6e-05 22.8 4.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETO04234.1 - 0.00051 19.7 3.1 0.00051 19.7 3.1 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-ANAPC11 PF12861.7 ETO04234.1 - 0.00071 19.6 1.5 0.0019 18.2 1.5 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_UBOX PF13445.6 ETO04234.1 - 0.0014 18.6 2.5 0.0059 16.6 2.5 2.1 1 1 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO04234.1 - 0.0018 18.1 2.7 0.0037 17.1 2.7 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO04234.1 - 0.0049 16.7 3.7 0.013 15.3 3.7 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ETO04234.1 - 0.005 16.4 3.8 0.013 15.2 3.8 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 ETO04234.1 - 0.022 15.0 7.5 0.12 12.6 7.0 2.4 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ETO04234.1 - 0.35 11.0 8.2 0.1 12.7 5.0 1.9 2 0 0 2 2 2 0 RING-variant domain PHD PF00628.29 ETO04234.1 - 1.5 8.8 7.3 5.6 6.9 5.9 2.5 1 1 1 2 2 2 0 PHD-finger zf-RING-like PF08746.11 ETO04234.1 - 1.5 9.1 5.0 6.3 7.2 5.0 2.1 1 1 0 1 1 1 0 RING-like domain Asp_Glu_race PF01177.22 ETO04235.1 - 4.3e-33 115.0 0.0 5.6e-33 114.7 0.0 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase Defensin_like PF10868.8 ETO04235.1 - 0.045 14.5 0.6 0.1 13.4 0.6 1.6 1 0 0 1 1 1 0 Cysteine-rich antifungal protein 2, defensin-like CDC45 PF02724.14 ETO04237.1 - 0.012 14.0 10.2 0.015 13.7 10.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO04237.1 - 0.012 13.9 13.6 0.016 13.5 13.6 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO04237.1 - 0.033 13.6 12.8 0.042 13.2 12.8 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 ETO04237.1 - 0.084 12.2 18.8 0.16 11.3 18.8 1.4 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO04237.1 - 0.16 12.3 19.7 0.81 10.1 18.0 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PNISR PF15996.5 ETO04237.1 - 0.95 9.7 10.8 1.6 8.9 10.8 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PI3K_1B_p101 PF10486.9 ETO04237.1 - 1.4 6.6 6.5 2 6.1 6.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Presenilin PF01080.17 ETO04237.1 - 2.4 6.8 8.6 3 6.5 8.6 1.3 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ETO04237.1 - 2.7 6.0 16.8 4.4 5.3 16.8 1.4 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 ETO04237.1 - 3.7 6.6 28.4 4.3 6.4 28.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2457) NTPase_1 PF03266.15 ETO04238.1 - 3.4e-11 43.3 0.4 5.7e-11 42.6 0.4 1.4 1 0 0 1 1 1 1 NTPase TLV_coat PF00429.19 ETO04238.1 - 0.036 12.7 0.2 0.042 12.5 0.2 1.1 1 0 0 1 1 1 0 ENV polyprotein (coat polyprotein) FYRC PF05965.14 ETO04239.1 - 0.00096 19.3 0.6 0.27 11.4 0.0 2.2 1 1 1 2 2 2 2 F/Y rich C-terminus Utp14 PF04615.13 ETO04241.1 - 1.1 7.8 26.7 1.4 7.4 26.7 1.2 1 0 0 1 1 1 0 Utp14 protein GOLD_2 PF13897.6 ETO04241.1 - 4.6 7.7 14.6 2.3 8.7 4.8 2.6 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking GREB1 PF15782.5 ETO04241.1 - 9 3.3 19.9 11 3.0 19.9 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Kelch_4 PF13418.6 ETO04242.1 - 9.5e-13 47.9 0.3 3.8e-08 33.2 0.1 3.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO04242.1 - 2e-11 43.3 1.1 2.8e-07 30.0 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO04242.1 - 5.4e-10 39.2 8.3 1.1e-05 25.5 0.3 5.3 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO04242.1 - 1.6e-07 31.0 3.4 0.015 15.3 0.4 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO04242.1 - 3.3e-05 23.8 0.0 1.6 8.8 0.0 3.6 3 0 0 3 3 3 2 Kelch motif TLD PF07534.16 ETO04243.1 - 2.4e-11 44.0 0.2 2.7e-11 43.8 0.2 1.3 1 1 0 1 1 1 1 TLD DHC PF09626.10 ETO04244.1 - 0.045 14.6 0.1 0.065 14.1 0.1 1.2 1 0 0 1 1 1 0 Dihaem cytochrome c DUF4832 PF16116.5 ETO04246.1 - 2.2e-05 24.4 0.0 3.4e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4832) DEP PF00610.21 ETO04247.1 - 6.1e-18 64.6 0.0 1.1e-17 63.8 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) START PF01852.19 ETO04249.1 - 7.8e-17 61.4 1.1 1.4e-14 54.0 0.4 2.9 2 1 1 3 3 3 2 START domain Nucleo_P87 PF07267.11 ETO04249.1 - 0.072 11.9 5.4 0.13 11.1 5.4 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FeoC PF09012.10 ETO04250.1 - 0.16 12.1 0.7 0.3 11.2 0.2 1.7 2 0 0 2 2 2 0 FeoC like transcriptional regulator Amb_V_allergen PF03913.13 ETO04251.1 - 0.051 13.5 0.2 0.08 12.9 0.2 1.3 1 0 0 1 1 1 0 Amb V Allergen RNA_pol_Rpb4 PF03874.16 ETO04252.1 - 0.96 9.8 8.7 1.9 8.8 8.7 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb4 60KD_IMP PF02096.20 ETO04252.1 - 3.3 7.6 8.9 1.4 8.8 5.8 1.8 2 0 0 2 2 2 0 60Kd inner membrane protein GFRP PF06399.13 ETO04254.1 - 0.039 13.8 0.0 0.091 12.7 0.0 1.6 1 1 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) SecA_DEAD PF07517.14 ETO04255.1 - 1.5e-08 34.3 0.0 1.5e-08 34.3 0.0 4.7 5 1 0 5 5 5 1 SecA DEAD-like domain Helicase_C PF00271.31 ETO04255.1 - 0.00048 20.5 0.0 0.005 17.2 0.0 3.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-4CXXC_R1 PF10497.9 ETO04255.1 - 0.03 14.5 0.4 0.1 12.8 0.4 1.9 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 ZZ PF00569.17 ETO04255.1 - 0.055 13.3 0.4 0.17 11.7 0.4 1.8 1 0 0 1 1 1 0 Zinc finger, ZZ type FUSC-like PF12805.7 ETO04255.1 - 0.68 9.0 5.4 4.6 6.2 2.6 3.1 2 1 0 2 2 2 0 FUSC-like inner membrane protein yccS AAA_lid_9 PF17871.1 ETO04255.1 - 5.3 7.0 11.7 5.9 6.9 6.9 3.9 2 1 0 2 2 2 0 AAA lid domain zf-C2H2 PF00096.26 ETO04256.1 - 7.1e-05 23.0 1.4 0.00023 21.4 1.4 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO04256.1 - 0.00021 21.9 0.9 0.00082 20.0 0.9 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETO04256.1 - 0.0016 18.4 0.8 0.0038 17.2 0.8 1.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ETO04256.1 - 0.0062 16.3 0.2 0.018 14.8 0.2 1.8 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-BED PF02892.15 ETO04256.1 - 0.021 14.8 0.3 0.065 13.3 0.3 1.8 1 0 0 1 1 1 0 BED zinc finger Evr1_Alr PF04777.13 ETO04256.1 - 0.14 12.7 2.3 0.2 12.2 0.0 2.4 3 0 0 3 3 3 0 Erv1 / Alr family zf-H2C2_5 PF13909.6 ETO04256.1 - 2.2 8.1 7.2 11 5.9 7.2 2.1 1 1 0 1 1 1 0 C2H2-type zinc-finger domain OmpH PF03938.14 ETO04256.1 - 3.3 8.0 19.3 1.8 8.9 3.7 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF1764 PF08576.10 ETO04256.1 - 9.9 7.1 13.9 1.5 9.8 2.8 2.5 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) vWA-TerF-like PF10138.9 ETO04258.1 - 0.077 13.1 0.1 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 vWA found in TerF C terminus TraD_N PF12615.8 ETO04259.1 - 0.0026 18.5 1.6 0.27 12.0 0.6 2.4 1 1 1 2 2 2 2 F sex factor protein N terminal FAD_binding_4 PF01565.23 ETO04259.1 - 0.082 12.6 0.0 0.24 11.1 0.0 1.8 2 0 0 2 2 2 0 FAD binding domain WD40 PF00400.32 ETO04260.1 - 4.9e-11 43.0 10.9 0.00027 21.7 0.4 4.6 4 1 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04260.1 - 0.031 12.9 1.6 0.91 8.1 0.0 2.6 1 1 1 3 3 3 0 Nucleoporin Nup120/160 Rox3 PF08633.10 ETO04261.1 - 0.022 15.0 0.1 0.023 15.0 0.1 1.2 1 0 0 1 1 1 0 Rox3 mediator complex subunit DUF3524 PF12038.8 ETO04261.1 - 0.032 14.1 0.2 0.044 13.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3524) Phage_TAC_3 PF06896.11 ETO04262.1 - 0.099 13.2 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone proteins, TAC VirD1 PF07328.11 ETO04262.1 - 0.12 12.3 0.0 0.18 11.7 0.0 1.3 1 1 0 1 1 1 0 T-DNA border endonuclease VirD1 YajC PF02699.15 ETO04264.1 - 0.34 10.8 5.0 2.1 8.3 2.2 2.9 2 0 0 2 2 2 0 Preprotein translocase subunit DOG1 PF14144.6 ETO04265.1 - 0.095 12.9 0.4 0.095 12.9 0.4 2.8 2 2 1 3 3 3 0 Seed dormancy control SHS2_FTSA PF02491.20 ETO04265.1 - 0.49 10.8 3.4 7.9 7.0 0.0 3.1 2 1 1 3 3 3 0 SHS2 domain inserted in FTSA Vpu PF00558.19 ETO04265.1 - 2.4 8.0 9.8 6.1 6.7 1.2 2.7 2 0 0 2 2 2 0 Vpu protein Laminin_B PF00052.18 ETO04265.1 - 4.7 7.1 9.4 0.17 11.7 2.0 2.3 2 1 0 2 2 2 0 Laminin B (Domain IV) WD40 PF00400.32 ETO04266.1 - 4.5e-32 109.6 13.7 5.2e-06 27.1 0.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04266.1 - 7.2e-13 48.7 0.6 0.0044 17.3 0.0 6.1 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04266.1 - 1e-07 31.6 9.7 0.00069 19.0 5.6 4.3 2 1 0 2 2 2 2 WD40-like domain DUF4979 PF16351.5 ETO04266.1 - 0.018 15.3 1.0 6.2 7.0 0.0 3.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4979) BING4CT PF08149.11 ETO04266.1 - 0.032 14.0 2.0 0.7 9.7 0.0 3.1 3 0 0 3 3 3 0 BING4CT (NUC141) domain PAN_1 PF00024.26 ETO04266.1 - 0.31 11.1 7.1 0.22 11.5 3.2 2.6 2 0 0 2 2 2 0 PAN domain SRX PF09201.10 ETO04270.1 - 0.46 10.3 4.8 8.9 6.1 0.1 3.0 3 1 0 3 3 3 0 SRX, signal recognition particle receptor alpha subunit DEAD PF00270.29 ETO04271.1 - 1.6e-09 37.8 0.3 2e-09 37.4 0.3 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase Med25_VWA PF11265.8 ETO04271.1 - 0.018 14.9 0.4 0.021 14.7 0.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A UspB PF10625.9 ETO04275.1 - 0.059 13.3 0.8 0.97 9.4 0.1 2.2 1 1 1 2 2 2 0 Universal stress protein B (UspB) FYVE_2 PF02318.16 ETO04275.1 - 0.17 12.1 3.9 2.6 8.3 0.1 2.7 3 0 0 3 3 3 0 FYVE-type zinc finger EnY2 PF10163.9 ETO04276.1 - 0.073 13.5 1.8 0.094 13.1 0.3 1.8 2 0 0 2 2 2 0 Transcription factor e(y)2 SNCAIP_SNCA_bd PF16700.5 ETO04276.1 - 0.12 12.1 1.8 0.22 11.3 0.1 2.2 2 0 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain zf-C3HC4_3 PF13920.6 ETO04277.1 - 6e-08 32.4 8.5 6e-08 32.4 8.5 2.1 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO04277.1 - 0.00012 21.9 8.8 0.00028 20.7 8.8 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 ETRAMP PF09716.10 ETO04277.1 - 0.042 13.9 1.6 0.28 11.2 0.0 2.7 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4834 PF16118.5 ETO04278.1 - 0.018 16.0 2.7 0.018 16.0 2.7 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) EMC3_TMCO1 PF01956.16 ETO04278.1 - 0.39 10.4 15.0 0.068 12.9 3.0 2.1 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF3149 PF11346.8 ETO04278.1 - 0.59 9.8 3.6 1.4 8.6 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) Zip PF02535.22 ETO04278.1 - 1.3 8.2 9.6 1e+02 1.9 9.6 2.1 1 1 0 1 1 1 0 ZIP Zinc transporter Tau95 PF09734.9 ETO04278.1 - 1.5 9.6 7.3 0.31 11.8 3.7 1.6 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Glycophorin_A PF01102.18 ETO04278.1 - 2.8 8.2 7.2 0.34 11.2 0.3 2.6 1 1 1 3 3 3 0 Glycophorin A AAA_7 PF12775.7 ETO04279.1 - 1.9e-05 24.2 0.0 4.1e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_lid_7 PF17867.1 ETO04279.1 - 8.9e-05 22.6 0.0 0.00029 21.0 0.0 1.8 2 0 0 2 2 2 1 Midasin AAA lid domain ABC_tran PF00005.27 ETO04279.1 - 0.066 13.7 0.3 0.14 12.7 0.3 1.7 1 1 0 1 1 1 0 ABC transporter HSP90 PF00183.18 ETO04280.1 - 6.8e-30 104.4 29.6 9.5e-15 54.5 2.9 4.0 2 1 2 4 4 4 3 Hsp90 protein DUF5412 PF17428.2 ETO04280.1 - 0.042 13.7 0.8 0.042 13.7 0.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5412) HATPase_c_3 PF13589.6 ETO04280.1 - 0.059 13.2 0.1 0.38 10.6 0.1 2.3 2 0 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ETO04280.1 - 0.072 13.6 0.0 0.14 12.7 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Fasciclin PF02469.22 ETO04280.1 - 0.091 13.0 2.4 0.57 10.4 0.3 2.4 2 0 0 2 2 2 0 Fasciclin domain RST PF12174.8 ETO04280.1 - 0.21 11.5 3.1 0.33 10.9 0.3 2.8 3 0 0 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain RVT_1 PF00078.27 ETO04281.1 - 9.7e-05 22.0 2.2 0.0002 20.9 0.0 2.2 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) GUCT PF08152.12 ETO04281.1 - 0.15 12.3 0.6 9.4 6.6 0.1 3.1 2 1 1 3 3 3 0 GUCT (NUC152) domain PUB PF09409.10 ETO04284.1 - 0.0045 16.9 3.1 0.015 15.2 0.1 2.8 2 1 0 2 2 2 1 PUB domain DUF1890 PF09001.11 ETO04286.1 - 0.027 14.9 0.0 0.035 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1890) FliW PF02623.15 ETO04286.1 - 0.1 12.5 0.0 0.13 12.2 0.0 1.1 1 0 0 1 1 1 0 FliW protein CHAT PF12770.7 ETO04287.1 - 0.00013 21.5 0.1 0.00018 21.0 0.1 1.3 1 0 0 1 1 1 1 CHAT domain DUF4550 PF15084.6 ETO04287.1 - 0.0022 18.3 0.3 0.96 9.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4550) Csa1 PF06023.12 ETO04289.1 - 0.086 12.2 2.0 0.2 11.0 2.0 1.5 1 1 0 1 1 1 0 CRISPR-associated exonuclease Csa1 DUF3323 PF11796.8 ETO04291.1 - 0.034 14.0 3.1 0.057 13.3 2.6 1.6 1 1 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) RCC1 PF00415.18 ETO04293.1 - 3.8e-41 139.5 11.7 1.3e-11 44.9 0.1 5.5 5 0 0 5 5 5 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO04293.1 - 2.4e-20 71.8 30.1 1.3e-06 28.0 0.3 6.4 6 0 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat TMEM214 PF10151.9 ETO04293.1 - 9.7 4.5 15.1 18 3.6 15.1 1.5 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Phosphoesterase PF04185.14 ETO04294.1 - 8.2e-51 173.3 2.2 1.2e-50 172.7 2.2 1.3 1 0 0 1 1 1 1 Phosphoesterase family KCT2 PF17818.1 ETO04295.1 - 0.032 14.3 0.7 0.064 13.4 0.7 1.4 1 0 0 1 1 1 0 Keratinocyte-associated gene product Roughex PF06020.11 ETO04296.1 - 0.037 13.1 1.0 0.046 12.8 1.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein CBFB_NFYA PF02045.15 ETO04296.1 - 0.039 14.6 1.9 0.039 14.6 1.9 2.2 2 0 0 2 2 2 0 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B TPR_12 PF13424.6 ETO04297.1 - 1.5e-07 31.6 0.0 4.1e-06 27.0 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04297.1 - 2.4e-06 27.2 0.0 0.0025 17.6 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04297.1 - 2.9e-06 26.9 3.9 0.021 14.6 0.3 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04297.1 - 3.1e-05 23.8 0.8 0.054 13.6 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04297.1 - 0.00021 21.1 0.0 0.016 15.2 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat Ten1 PF12658.7 ETO04297.1 - 0.0058 16.6 0.0 0.0073 16.2 0.0 1.2 1 0 0 1 1 1 1 Telomere capping, CST complex subunit s48_45 PF07422.13 ETO04297.1 - 0.0082 16.7 2.2 0.0084 16.7 2.2 1.2 1 0 0 1 1 1 1 Sexual stage antigen s48/45 domain TPR_17 PF13431.6 ETO04297.1 - 0.015 15.7 1.5 7.9 7.1 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04297.1 - 0.015 15.5 5.6 0.88 9.9 0.3 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO04297.1 - 0.056 13.1 0.8 9.3 6.0 0.0 2.4 2 1 0 2 2 2 0 TPR repeat Sporozoite_P67 PF05642.11 ETO04298.1 - 0.77 7.8 4.2 0.85 7.6 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.9 ETO04298.1 - 7.9 5.5 10.4 12 4.9 10.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SR-25 PF10500.9 ETO04299.1 - 7.3 6.1 10.2 12 5.5 10.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein O_anti_polymase PF01901.16 ETO04300.1 - 0.051 12.8 6.5 0.074 12.3 6.5 1.2 1 0 0 1 1 1 0 Putative O-antigen polymerase LRR_8 PF13855.6 ETO04301.1 - 6.1e-08 32.3 19.5 0.00063 19.5 3.3 5.8 3 1 2 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ETO04301.1 - 0.0062 16.9 28.3 0.045 14.2 0.8 6.8 4 1 4 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO04301.1 - 3 8.8 8.2 3.5e+02 2.4 0.1 6.5 5 1 0 5 5 5 0 Leucine Rich Repeat WD40 PF00400.32 ETO04304.1 - 2e-17 63.2 5.0 1.3e-05 25.9 0.2 4.7 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04304.1 - 9.4e-05 22.6 0.2 0.79 10.1 0.0 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04304.1 - 0.00039 19.2 1.0 1.4 7.5 0.0 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 LydB PF16084.5 ETO04304.1 - 0.085 12.7 0.1 0.35 10.7 0.0 1.9 1 1 1 2 2 2 0 LydA-holin antagonist Gal4_dimer PF03902.13 ETO04306.1 - 0.0045 17.1 0.0 0.0093 16.1 0.0 1.5 1 0 0 1 1 1 1 Gal4-like dimerisation domain IMUP PF15761.5 ETO04306.1 - 0.42 11.3 15.5 0.86 10.3 15.0 1.8 1 1 1 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 ETO04306.1 - 5.8 6.4 18.5 4.3 6.9 16.8 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Spo12 PF05032.12 ETO04309.1 - 0.046 13.6 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 Spo12 family RRM_1 PF00076.22 ETO04312.1 - 2.5e-17 62.5 0.1 7.4e-17 60.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO04312.1 - 0.00049 20.2 0.0 0.0015 18.6 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 ETO04312.1 - 0.009 15.6 0.0 0.071 12.7 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GTP-bdg_M PF16360.5 ETO04312.1 - 2.1 9.0 6.0 23 5.7 0.4 2.7 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Jnk-SapK_ap_N PF09744.9 ETO04312.1 - 2.7 8.2 18.2 0.21 11.8 12.9 1.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 LRR_9 PF14580.6 ETO04313.1 - 0.063 12.8 1.6 2.3 7.7 0.0 2.9 3 1 1 4 4 4 0 Leucine-rich repeat DUF4758 PF15950.5 ETO04313.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein AIG1 PF04548.16 ETO04314.1 - 3.4e-14 52.7 0.6 5.4e-14 52.0 0.0 1.6 2 0 0 2 2 2 1 AIG1 family MMR_HSR1 PF01926.23 ETO04314.1 - 1.2e-05 25.3 0.0 6.5e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATPase PF06745.13 ETO04314.1 - 0.0043 16.4 1.7 0.033 13.5 0.0 2.5 2 1 0 2 2 2 1 KaiC RsgA_GTPase PF03193.16 ETO04314.1 - 0.0076 16.2 0.0 0.14 12.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase RNA_helicase PF00910.22 ETO04314.1 - 0.011 16.1 0.0 0.044 14.2 0.0 2.1 1 1 0 1 1 1 0 RNA helicase Methyltransf_14 PF08484.11 ETO04314.1 - 0.014 15.3 0.6 0.029 14.2 0.1 1.7 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain Roc PF08477.13 ETO04314.1 - 0.014 15.6 0.0 0.092 13.0 0.0 2.5 2 1 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase HNOB PF07700.15 ETO04314.1 - 0.017 15.1 0.5 1.1 9.3 0.1 3.1 2 1 1 3 3 3 0 Haem-NO-binding ATPase_2 PF01637.18 ETO04314.1 - 0.024 14.6 0.4 0.094 12.6 0.0 2.1 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ETO04314.1 - 0.05 13.9 0.1 0.29 11.4 0.0 2.2 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETO04314.1 - 0.059 13.1 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 ETO04314.1 - 0.098 13.2 2.8 0.33 11.5 0.0 2.3 1 1 1 2 2 2 0 ABC transporter AAA PF00004.29 ETO04314.1 - 0.14 12.5 1.0 3.2 8.2 0.0 3.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ETO04314.1 - 0.48 10.9 9.3 11 6.5 8.3 2.2 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ETO04314.1 - 0.49 10.4 5.1 4.7 7.2 5.1 2.9 1 1 0 1 1 1 0 Dynamin family WD40 PF00400.32 ETO04315.1 - 1.5e-29 101.6 20.0 1.2e-05 25.9 0.1 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04315.1 - 2.7e-09 37.2 3.2 0.049 13.9 0.1 4.9 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04315.1 - 1.8e-06 26.9 4.8 0.0057 15.4 0.8 4.2 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Alpha_adaptinC2 PF02883.20 ETO04316.1 - 0.28 11.5 3.3 7.7 6.9 0.5 2.2 2 0 0 2 2 2 0 Adaptin C-terminal domain Velvet PF11754.8 ETO04317.1 - 0.0042 17.1 1.5 0.005 16.8 1.5 1.1 1 0 0 1 1 1 1 Velvet factor CDC45 PF02724.14 ETO04317.1 - 0.086 11.1 4.6 0.097 11.0 4.6 1.0 1 0 0 1 1 1 0 CDC45-like protein OATP PF03137.20 ETO04317.1 - 0.38 9.0 1.4 0.5 8.6 1.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 ETO04317.1 - 0.84 8.3 2.8 0.78 8.4 2.8 1.1 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO04318.1 - 5.4e-63 207.4 26.7 4.2e-10 40.1 0.2 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04318.1 - 9.1e-23 80.4 3.4 0.00023 21.4 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04318.1 - 7.2e-15 54.8 0.8 0.0077 15.2 0.1 7.0 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO04318.1 - 2.4e-11 43.0 12.8 2.2e-05 24.0 0.5 2.9 2 1 2 4 4 4 3 Pentapeptide repeats (8 copies) WD40_like PF17005.5 ETO04318.1 - 3.3e-10 39.8 0.0 0.043 13.1 0.0 4.1 3 2 1 4 4 4 3 WD40-like domain Pentapeptide_4 PF13599.6 ETO04318.1 - 2.3e-05 24.5 4.3 0.00034 20.7 3.1 3.1 3 0 0 3 3 3 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO04318.1 - 0.00022 21.1 10.8 15 5.7 0.0 6.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO04318.1 - 0.00084 19.4 3.1 0.022 14.9 2.7 3.0 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) 3-dmu-9_3-mt PF06983.13 ETO04318.1 - 0.021 15.4 0.6 1.2 9.7 0.1 3.1 1 1 1 2 2 2 0 3-demethylubiquinone-9 3-methyltransferase Frtz PF11768.8 ETO04318.1 - 0.064 11.6 0.1 5.4 5.2 0.0 2.8 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz PRAI PF00697.22 ETO04319.1 - 0.055 13.2 0.1 0.058 13.2 0.1 1.1 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase ArfGap PF01412.18 ETO04320.1 - 6.5e-28 97.2 1.7 9.9e-28 96.6 0.1 2.2 2 1 1 3 3 3 1 Putative GTPase activating protein for Arf FMO-like PF00743.19 ETO04321.1 - 2.7e-05 22.8 0.0 3.3e-05 22.5 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like ADK PF00406.22 ETO04322.1 - 8.1e-09 35.7 0.0 9.7e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETO04322.1 - 0.0077 16.7 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain dNK PF01712.19 ETO04322.1 - 0.023 14.5 0.0 0.024 14.5 0.0 1.1 1 0 0 1 1 1 0 Deoxynucleoside kinase DUF4637 PF15470.6 ETO04323.1 - 0.49 10.1 5.9 0.67 9.7 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RRM_1 PF00076.22 ETO04324.1 - 5.9e-14 51.6 0.6 1.5e-06 27.9 0.2 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RL PF17797.1 ETO04324.1 - 0.023 14.6 0.2 1.5 8.9 0.0 2.7 2 1 1 3 3 3 0 RL domain DUF1298 PF06974.13 ETO04325.1 - 3.6e-10 40.0 0.0 5.9e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) Condensation PF00668.20 ETO04325.1 - 2.6e-05 23.1 0.1 4.3e-05 22.4 0.1 1.4 1 0 0 1 1 1 1 Condensation domain WES_acyltransf PF03007.16 ETO04325.1 - 0.038 13.8 0.0 0.29 10.8 0.0 2.4 1 1 0 1 1 1 0 Wax ester synthase-like Acyl-CoA acyltransferase domain Csa1 PF06023.12 ETO04326.1 - 0.0091 15.4 1.3 0.01 15.2 1.3 1.1 1 0 0 1 1 1 1 CRISPR-associated exonuclease Csa1 Kazal_1 PF00050.21 ETO04326.1 - 0.073 13.1 0.1 0.19 11.7 0.0 1.8 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain ERp29 PF07749.12 ETO04326.1 - 0.13 13.2 2.8 0.15 13.0 2.1 1.4 1 1 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain WD40 PF00400.32 ETO04327.1 - 9.3e-37 124.4 19.6 3.9e-08 33.8 0.8 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04327.1 - 1.1e-07 32.1 0.3 0.038 14.3 0.0 5.1 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04327.1 - 2.4e-06 26.5 11.2 0.12 11.0 0.4 4.8 2 2 2 4 4 4 4 Nucleoporin Nup120/160 TRAM_LAG1_CLN8 PF03798.16 ETO04327.1 - 0.3 10.8 3.9 0.47 10.2 3.9 1.2 1 0 0 1 1 1 0 TLC domain 7tm_3 PF00003.22 ETO04328.1 - 5.8e-05 22.9 7.7 7.2e-05 22.6 7.7 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR UPF0020 PF01170.18 ETO04329.1 - 6.8e-17 61.8 0.0 1.4e-16 60.8 0.0 1.6 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 MTS PF05175.14 ETO04329.1 - 2.8e-05 23.7 0.0 0.00081 19.0 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain N6-adenineMlase PF10237.9 ETO04329.1 - 0.00024 20.9 0.0 0.00065 19.5 0.0 1.7 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase AviRa PF11599.8 ETO04329.1 - 0.00046 19.7 0.2 0.0014 18.2 0.0 1.8 1 1 1 2 2 2 1 RRNA methyltransferase AviRa N6_Mtase PF02384.16 ETO04329.1 - 0.00067 19.0 0.1 0.0025 17.1 0.0 1.9 1 1 1 2 2 2 1 N-6 DNA Methylase THUMP PF02926.17 ETO04329.1 - 0.0013 18.9 0.1 0.0057 16.7 0.0 2.1 2 0 0 2 2 2 1 THUMP domain Methyltransf_31 PF13847.6 ETO04329.1 - 0.012 15.4 0.0 0.054 13.3 0.0 2.1 1 1 0 1 1 1 0 Methyltransferase domain DinI PF06183.13 ETO04329.1 - 0.16 12.4 0.0 25 5.3 0.0 2.7 2 0 0 2 2 2 0 DinI-like family Myotub-related PF06602.14 ETO04330.1 - 1.8e-75 254.1 0.9 2.6e-75 253.6 0.9 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain FYVE PF01363.21 ETO04330.1 - 1.1e-13 51.1 9.4 2.7e-13 49.8 9.4 1.6 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ETO04330.1 - 8.3e-05 22.8 5.9 0.00021 21.5 5.9 1.7 1 0 0 1 1 1 1 FYVE-type zinc finger Y_phosphatase3 PF13350.6 ETO04330.1 - 0.15 12.0 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Zip PF02535.22 ETO04331.1 - 0.043 13.0 0.4 0.094 11.9 0.4 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Vta1 PF04652.16 ETO04332.1 - 0.058 13.4 8.9 0.068 13.1 6.5 2.5 1 1 1 2 2 2 0 Vta1 like MSA-2c PF12238.8 ETO04332.1 - 4.2 7.3 7.5 0.6 10.1 2.6 2.1 3 0 0 3 3 3 0 Merozoite surface antigen 2c ClpB_D2-small PF10431.9 ETO04335.1 - 4.4e-06 26.7 0.6 7.9e-06 25.9 0.2 1.7 2 1 0 2 2 2 1 C-terminal, D2-small domain, of ClpB protein Colicin PF01024.19 ETO04335.1 - 0.04 13.8 0.2 0.047 13.6 0.2 1.1 1 0 0 1 1 1 0 Colicin pore forming domain Pkinase PF00069.25 ETO04336.1 - 1.2e-58 198.6 0.0 2.5e-58 197.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04336.1 - 1.3e-21 77.1 0.0 4e-21 75.5 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO04336.1 - 0.0063 15.9 0.0 0.022 14.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like DUF4298 PF14131.6 ETO04337.1 - 0.055 13.4 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) Pkinase PF00069.25 ETO04338.1 - 1.5e-13 50.7 0.0 2.1e-13 50.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04338.1 - 0.063 12.6 0.0 0.08 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase NPR3 PF03666.13 ETO04338.1 - 2.2 7.0 4.5 3.2 6.5 4.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2201_N PF13203.6 ETO04339.1 - 0.16 11.5 6.4 1.2 8.7 0.3 2.0 1 1 1 2 2 2 0 Putative metallopeptidase domain WD40 PF00400.32 ETO04340.1 - 1e-22 80.0 18.8 6.8e-08 33.1 1.3 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO04340.1 - 1.4e-07 30.5 1.8 0.018 13.7 0.2 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04340.1 - 1.8e-06 28.1 0.1 0.026 14.8 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO04341.1 - 8e-14 51.8 7.7 1.9e-07 31.7 1.9 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04341.1 - 0.0004 19.2 1.3 0.03 13.0 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO04341.1 - 0.0026 17.2 0.4 0.0038 16.6 0.4 1.2 1 0 0 1 1 1 1 WD40-like domain WD40 PF00400.32 ETO04342.1 - 6.6e-18 64.7 1.7 7.1e-09 36.2 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04342.1 - 2.4e-05 24.5 0.1 0.56 10.5 0.0 3.6 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ricin_B_lectin PF00652.22 ETO04342.1 - 0.0052 17.0 1.3 0.0092 16.2 1.3 1.4 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Nup160 PF11715.8 ETO04342.1 - 0.047 12.3 0.2 0.48 9.0 0.2 2.2 1 1 0 1 1 1 0 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO04342.1 - 0.074 12.0 0.3 0.73 8.7 0.0 2.3 1 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Ribosomal_S5_C PF03719.15 ETO04343.1 - 1.4e-24 85.3 0.1 2.1e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Ribosomal_S5 PF00333.20 ETO04343.1 - 2e-24 85.3 0.3 2e-24 85.3 0.3 1.7 2 0 0 2 2 2 1 Ribosomal protein S5, N-terminal domain E_Pc_C PF06752.12 ETO04344.1 - 0.1 12.7 4.1 0.063 13.4 1.4 1.9 1 1 0 1 1 1 0 Enhancer of Polycomb C-terminus WD40 PF00400.32 ETO04346.1 - 1e-22 80.0 15.6 1.1e-06 29.3 2.9 5.9 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04346.1 - 3.5e-08 33.6 0.1 0.0056 17.0 0.0 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04346.1 - 1.8e-06 26.9 1.1 0.039 12.6 0.3 3.1 2 2 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO04346.1 - 0.00011 21.6 0.9 1.9 7.7 0.0 3.7 2 1 2 4 4 4 3 WD40-like domain Nucleoporin_N PF08801.11 ETO04346.1 - 0.037 12.8 7.6 0.28 9.9 0.1 3.3 2 1 1 3 3 3 0 Nup133 N terminal like WD40 PF00400.32 ETO04347.1 - 4.5e-23 81.1 20.3 8.7e-06 26.4 2.0 8.2 7 2 0 7 7 7 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO04347.1 - 3.1e-06 26.1 7.7 0.23 10.1 0.1 4.2 1 1 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04347.1 - 5.7e-06 26.5 1.5 0.26 11.6 0.0 5.2 3 2 2 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO04347.1 - 0.00062 18.6 4.7 0.09 11.5 1.0 3.5 1 1 0 2 2 2 2 Nup133 N terminal like WD40 PF00400.32 ETO04349.1 - 2.1e-50 167.6 12.3 1.2e-09 38.6 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04349.1 - 7.6e-25 87.0 0.8 0.0011 19.2 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04349.1 - 5.2e-12 45.7 0.9 7.8e-05 22.1 0.1 3.1 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO04349.1 - 2.5e-11 43.1 0.0 0.016 14.2 0.0 4.9 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO04349.1 - 4.7e-08 32.1 3.5 0.22 10.1 0.0 4.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO04349.1 - 9.7e-06 25.7 0.2 0.63 10.1 0.0 4.1 1 1 2 4 4 4 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO04349.1 - 7.9e-05 21.6 2.7 1 8.0 0.2 3.4 1 1 1 3 3 3 3 Nup133 N terminal like PD40 PF07676.12 ETO04349.1 - 0.00084 19.2 2.1 46 4.1 0.0 5.7 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO04349.1 - 0.0013 17.8 4.1 0.3 10.0 0.1 4.1 1 1 1 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO04349.1 - 0.0031 16.1 0.1 0.41 9.1 0.0 2.3 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nop10p PF04135.12 ETO04349.1 - 0.022 14.8 0.3 6.6 6.9 0.0 2.7 3 0 0 3 3 3 0 Nucleolar RNA-binding protein, Nop10p family GDPD_2 PF13653.6 ETO04349.1 - 0.023 15.2 0.1 1.1e+02 3.4 0.0 4.4 5 0 0 5 5 5 0 Glycerophosphoryl diester phosphodiesterase family PQQ PF01011.21 ETO04349.1 - 0.033 14.1 0.0 70 3.6 0.0 4.3 5 0 0 5 5 5 0 PQQ enzyme repeat RabGAP-TBC PF00566.18 ETO04350.1 - 2.6e-08 33.8 1.7 3.3e-08 33.5 1.7 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain U-box PF04564.15 ETO04351.1 - 1.3e-10 41.2 0.0 4.4e-10 39.6 0.0 2.0 1 0 0 1 1 1 1 U-box domain ODV-E18 PF10717.9 ETO04351.1 - 0.41 10.5 1.6 0.71 9.8 1.6 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 DUF2203 PF09969.9 ETO04352.1 - 0.09 13.5 1.6 0.13 13.0 1.6 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Selenoprotein_S PF06936.11 ETO04353.1 - 0.13 12.1 5.4 0.15 11.8 5.4 1.0 1 0 0 1 1 1 0 Selenoprotein S (SelS) WD40 PF00400.32 ETO04354.1 - 2.1e-33 113.8 21.8 8.3e-07 29.6 1.0 6.3 5 2 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO04354.1 - 3.9e-11 42.3 4.6 0.0027 16.4 0.1 5.0 1 1 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04354.1 - 8.9e-10 38.7 0.3 0.057 13.7 0.0 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain N6-adenineMlase PF10237.9 ETO04356.1 - 0.028 14.2 2.6 0.043 13.6 2.6 1.2 1 0 0 1 1 1 0 Probable N6-adenine methyltransferase YidD PF01809.18 ETO04356.1 - 0.042 13.7 0.0 0.084 12.8 0.0 1.5 1 0 0 1 1 1 0 Putative membrane protein insertion efficiency factor WD40 PF00400.32 ETO04357.1 - 3.2e-34 116.4 18.8 1.5e-07 32.0 1.2 7.7 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO04357.1 - 3.5e-08 32.5 3.8 0.096 11.3 0.1 4.8 3 1 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04357.1 - 3.3e-06 27.3 0.2 4.8 7.6 0.0 4.4 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO04357.1 - 0.0086 15.7 1.7 0.24 10.9 0.1 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4221) WD40 PF00400.32 ETO04358.1 - 6.8e-42 140.7 25.4 2e-07 31.6 0.2 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04358.1 - 3.8e-12 46.3 2.1 0.049 13.9 0.0 5.3 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04358.1 - 4.1e-08 32.3 6.6 0.35 9.4 0.1 5.0 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Rod_C PF10493.9 ETO04359.1 - 0.03 12.7 0.6 0.035 12.5 0.6 1.0 1 0 0 1 1 1 0 Rough deal protein C-terminal region RL10P_insert PF17777.1 ETO04359.1 - 0.19 11.7 0.0 0.65 10.0 0.0 1.8 1 1 1 2 2 2 0 Insertion domain in 60S ribosomal protein L10P PPR_2 PF13041.6 ETO04360.1 - 5.9e-14 52.0 10.3 3.7e-05 23.8 2.1 5.4 5 1 1 6 6 6 3 PPR repeat family PPR PF01535.20 ETO04360.1 - 8.6e-10 38.2 7.6 0.027 14.7 0.2 4.6 4 0 0 4 4 4 3 PPR repeat PPR_1 PF12854.7 ETO04360.1 - 5.3e-06 26.0 2.6 0.21 11.4 0.0 3.8 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 ETO04360.1 - 1.5e-05 25.0 1.4 0.0059 16.7 0.2 3.5 2 1 1 3 3 3 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO04360.1 - 0.0082 15.5 2.2 3.4 7.0 0.0 2.7 2 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP Dehydratase_SU PF02287.15 ETO04360.1 - 0.028 14.5 0.1 0.059 13.4 0.1 1.6 1 0 0 1 1 1 0 Dehydratase small subunit EZH2_N PF18601.1 ETO04360.1 - 0.11 12.8 2.0 20 5.6 0.0 3.4 4 0 0 4 4 4 0 EZH2 N-terminal domain WD40 PF00400.32 ETO04361.1 - 2.5e-23 81.9 13.8 4.7e-07 30.4 0.6 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO04361.1 - 1.7e-07 30.3 1.1 0.082 11.5 0.1 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04361.1 - 4.1e-07 30.2 0.8 0.033 14.5 0.0 3.3 2 2 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04361.1 - 0.0057 16.0 1.3 0.0057 16.0 1.3 3.6 1 1 2 3 3 3 1 WD40-like domain Geminin PF07412.12 ETO04361.1 - 0.014 15.1 17.9 0.032 14.0 5.7 2.7 1 1 1 2 2 2 0 Geminin ZYG-11_interact PF05884.12 ETO04361.1 - 0.18 11.2 3.7 0.25 10.7 3.7 1.2 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF3682 PF12446.8 ETO04361.1 - 0.23 11.9 4.6 0.37 11.3 4.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) She9_MDM33 PF05546.11 ETO04361.1 - 1.9 8.2 12.1 6 6.6 12.1 1.7 1 1 0 1 1 1 0 She9 / Mdm33 family APG6_N PF17675.1 ETO04361.1 - 5.2 7.6 12.2 9.1 6.8 12.2 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Kelch_5 PF13854.6 ETO04362.1 - 4.9e-06 26.4 3.6 0.9 9.6 1.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO04362.1 - 0.00031 20.9 5.5 0.88 10.0 0.3 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO04362.1 - 0.00032 20.6 3.7 0.087 12.8 0.3 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO04362.1 - 0.00066 19.6 0.1 0.016 15.2 0.0 2.8 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO04362.1 - 0.0012 18.4 2.0 0.055 13.1 0.2 2.9 3 0 0 3 3 3 1 Kelch motif TPR_12 PF13424.6 ETO04363.1 - 5.6e-24 84.2 0.3 2.7e-12 46.8 0.0 2.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04363.1 - 5.3e-13 48.4 0.1 3.3e-08 33.1 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04363.1 - 2.8e-08 33.2 3.0 0.0021 18.0 0.4 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04363.1 - 5.4e-08 32.3 8.0 0.0015 18.2 1.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04363.1 - 1.8e-06 27.7 7.5 0.0027 17.8 0.7 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04363.1 - 4.6e-05 23.1 0.1 0.0053 16.7 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO04363.1 - 0.00012 22.2 0.3 0.069 13.6 0.0 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat PPR PF01535.20 ETO04363.1 - 0.005 17.0 1.2 0.023 14.9 0.2 2.3 2 0 0 2 2 2 1 PPR repeat SNAP PF14938.6 ETO04363.1 - 0.011 15.2 0.1 0.015 14.7 0.1 1.1 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO04363.1 - 0.053 13.3 2.9 0.28 11.0 2.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5113) Cohesin_load PF10345.9 ETO04363.1 - 0.1 11.0 5.3 0.025 13.0 1.7 1.6 2 0 0 2 2 2 0 Cohesin loading factor HDV_ag PF01517.18 ETO04363.1 - 0.17 11.7 0.1 0.2 11.4 0.1 1.1 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen Polbeta PF18765.1 ETO04364.1 - 0.016 15.3 1.1 0.035 14.2 1.1 1.7 1 1 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase PPR_2 PF13041.6 ETO04365.1 - 1.6e-17 63.4 10.6 1e-09 38.4 0.4 4.9 3 1 2 5 5 5 4 PPR repeat family PPR PF01535.20 ETO04365.1 - 5.1e-17 60.8 4.0 6.2e-05 23.0 0.0 5.0 4 0 0 4 4 4 4 PPR repeat PPR_3 PF13812.6 ETO04365.1 - 2.7e-14 53.0 6.3 6.4e-07 29.4 0.3 4.9 3 1 2 5 5 5 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO04365.1 - 6.4e-10 38.6 7.0 0.00043 19.9 0.0 5.2 5 0 0 5 5 5 2 PPR repeat PPR_long PF17177.4 ETO04365.1 - 6.3e-08 32.2 0.0 1.2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF3636 PF12331.8 ETO04365.1 - 0.043 13.7 1.2 0.09 12.6 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) HSP70 PF00012.20 ETO04366.1 - 2.7e-48 164.6 0.7 1e-32 113.2 1.1 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO04366.1 - 4.2e-10 39.0 0.8 6e-10 38.4 0.8 1.3 1 1 0 1 1 1 1 MreB/Mbl protein MRG PF05712.13 ETO04366.1 - 0.018 14.4 0.2 0.05 12.9 0.1 1.7 1 1 1 2 2 2 0 MRG HSP70 PF00012.20 ETO04367.1 - 3.7e-08 32.0 0.0 6e-08 31.3 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein RACo_C_ter PF14574.6 ETO04368.1 - 1.7 7.6 4.3 0.48 9.4 1.0 1.6 2 0 0 2 2 2 0 C-terminal domain of RACo the ASKHA domain WD40 PF00400.32 ETO04371.1 - 8.8e-40 134.0 29.8 3.8e-06 27.5 1.9 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04371.1 - 3.3e-15 56.2 2.5 0.00086 19.6 0.0 5.9 4 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04371.1 - 1.7e-10 40.2 12.5 0.0064 15.2 0.5 6.1 1 1 4 6 6 6 6 Nucleoporin Nup120/160 V-ATPase_G PF03179.15 ETO04371.1 - 1.7 9.2 9.7 5.4 7.6 9.7 1.9 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit SH3_13 PF18335.1 ETO04371.1 - 1.8 8.4 8.7 4.2 7.3 0.0 4.5 5 0 0 5 5 5 0 ATP-dependent RecD-like DNA helicase SH3 domain WD40 PF00400.32 ETO04373.1 - 5.4e-15 55.5 14.4 2.7e-05 24.8 0.6 4.2 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04373.1 - 1.8e-05 25.0 2.0 0.11 12.8 0.1 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04373.1 - 0.0017 17.7 1.4 0.15 11.4 0.1 2.6 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO04373.1 - 0.003 16.3 1.2 0.74 8.4 0.1 2.5 1 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF1921 PF09081.10 ETO04373.1 - 4.5 7.6 7.1 39 4.6 0.0 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1921) DUF4619 PF15398.6 ETO04374.1 - 0.02 14.4 2.7 0.023 14.2 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4619) TFX_C PF14601.6 ETO04376.1 - 0.021 14.8 0.5 0.081 12.9 0.5 2.0 1 0 0 1 1 1 0 DNA_binding protein, TFX, C-term DUF3584 PF12128.8 ETO04377.1 - 0.00072 17.2 19.2 0.0013 16.4 19.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF190 PF02641.15 ETO04377.1 - 0.048 14.0 0.6 0.18 12.2 0.6 2.0 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 SAM_LFY PF01698.16 ETO04377.1 - 0.065 13.2 0.3 0.25 11.3 0.0 2.0 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain DUF1967 PF09269.11 ETO04377.1 - 0.089 12.7 0.5 0.46 10.5 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1967) ATP-synt_F6 PF05511.11 ETO04377.1 - 0.13 12.6 3.5 0.41 11.1 2.4 2.5 2 1 0 2 2 2 0 Mitochondrial ATP synthase coupling factor 6 MID_pPIWI_RE PF18157.1 ETO04377.1 - 0.5 10.7 3.3 0.39 11.0 0.5 2.2 3 0 0 3 3 3 0 MID domain of pPIWI_RE DUF4239 PF14023.6 ETO04377.1 - 2.3 7.9 9.3 0.74 9.5 5.1 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF4239) DUF2779 PF11074.8 ETO04377.1 - 4.1 7.9 17.9 4.4 7.8 9.4 3.4 1 1 1 2 2 2 0 Domain of unknown function(DUF2779) OrsD PF12013.8 ETO04377.1 - 8 7.0 7.4 1.9 8.9 1.0 2.9 1 1 1 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D Peptidase_S28 PF05577.12 ETO04378.1 - 1e-48 166.2 7.1 5e-28 98.1 0.2 2.4 2 1 0 2 2 2 2 Serine carboxypeptidase S28 DUF4452 PF14618.6 ETO04378.1 - 0.19 11.6 0.0 0.31 10.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) XhlA PF10779.9 ETO04379.1 - 0.033 14.4 0.6 0.033 14.4 0.6 3.3 2 1 1 3 3 3 0 Haemolysin XhlA DEAD PF00270.29 ETO04379.1 - 0.038 13.8 4.9 0.03 14.1 2.0 2.1 1 1 2 3 3 3 0 DEAD/DEAH box helicase DUF2400 PF09674.10 ETO04379.1 - 0.039 13.9 7.6 0.12 12.4 4.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF2400) BLOC1_2 PF10046.9 ETO04379.1 - 0.06 13.7 15.0 0.11 12.8 2.0 4.1 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 ETO04379.1 - 0.36 11.3 6.1 19 5.8 6.1 2.9 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF4407 PF14362.6 ETO04379.1 - 1.4 8.2 10.2 2.2 7.6 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Prenyltransf PF01255.19 ETO04379.1 - 2.2 7.8 7.4 11 5.5 7.2 2.1 1 1 0 1 1 1 0 Putative undecaprenyl diphosphate synthase DUF948 PF06103.11 ETO04379.1 - 3.8 7.8 9.3 1.4 9.3 1.5 3.1 2 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF2235 PF09994.9 ETO04379.1 - 5.7 6.2 6.9 12 5.1 6.7 1.7 1 1 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) RRM_1 PF00076.22 ETO04381.1 - 0.04 13.8 0.0 0.16 11.8 0.0 2.1 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Poty_coat PF00767.18 ETO04381.1 - 0.05 13.2 0.0 0.12 11.9 0.0 1.7 1 0 0 1 1 1 0 Potyvirus coat protein Phage_tail_APC PF16778.5 ETO04381.1 - 0.34 10.8 1.5 17 5.4 0.0 4.1 5 0 0 5 5 5 0 Phage tail assembly chaperone protein Urotensin_II PF02083.15 ETO04381.1 - 1.4 8.7 5.6 6 6.8 5.6 2.1 1 0 0 1 1 1 0 Urotensin II BspA_v PF18220.1 ETO04382.1 - 0.073 13.2 1.2 0.17 12.0 1.2 1.5 1 0 0 1 1 1 0 Adhesin BspA variable domain SRI PF08236.11 ETO04383.1 - 0.016 15.4 0.1 0.033 14.4 0.1 1.6 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain bVLRF1 PF18826.1 ETO04383.1 - 0.088 12.7 0.2 0.4 10.5 0.1 1.9 2 0 0 2 2 2 0 bacteroidetes VLRF1 release factor WD40 PF00400.32 ETO04385.1 - 1.7e-33 114.1 22.4 1.5e-07 32.0 0.3 7.5 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04385.1 - 1.7e-10 41.1 0.8 0.11 12.8 0.0 5.7 4 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04385.1 - 5.2e-09 35.3 3.9 0.1 11.3 0.2 5.5 1 1 3 6 6 6 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO04385.1 - 8.5e-05 21.5 6.8 0.55 8.9 0.0 4.9 3 2 2 5 5 5 4 Nup133 N terminal like WD40 PF00400.32 ETO04386.1 - 2.2e-13 50.5 5.9 7.6e-06 26.6 0.4 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04386.1 - 3.4e-07 29.3 3.0 0.00041 19.1 1.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04386.1 - 0.035 14.4 0.1 0.15 12.4 0.1 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WYL_2 PF10902.8 ETO04386.1 - 0.17 12.3 1.0 23 5.4 0.1 2.8 3 0 0 3 3 3 0 WYL_2, Sm-like SH3 beta-barrel fold Methyltransf_12 PF08242.12 ETO04387.1 - 0.12 13.1 2.2 0.38 11.5 2.2 1.8 1 0 0 1 1 1 0 Methyltransferase domain DUF3439 PF11921.8 ETO04387.1 - 0.93 9.5 8.3 2.2 8.2 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Apis_Csd PF11671.8 ETO04387.1 - 1.9 8.5 7.8 2.8 8.0 5.7 2.1 2 0 0 2 2 2 0 Complementary sex determiner protein WD40 PF00400.32 ETO04388.1 - 0.0021 18.9 1.5 0.035 15.0 1.5 2.6 1 1 0 1 1 1 1 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO04388.1 - 0.0028 18.3 0.9 0.0028 18.3 0.9 2.9 3 0 0 3 3 3 1 TRAF-type zinc finger Baculo_19 PF04798.12 ETO04388.1 - 0.31 10.8 3.6 1.7 8.4 0.0 2.8 2 1 0 2 2 2 0 Baculovirus 19 kDa protein conserved region TFIIF_alpha PF05793.12 ETO04389.1 - 0.00061 18.5 13.3 0.00061 18.5 13.3 1.1 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2457 PF10446.9 ETO04389.1 - 0.0016 17.7 14.2 0.0016 17.7 14.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) YL1 PF05764.13 ETO04389.1 - 0.004 17.3 14.7 0.0041 17.3 14.7 1.1 1 0 0 1 1 1 1 YL1 nuclear protein Arteri_nucleo PF01481.16 ETO04389.1 - 0.016 15.5 0.3 0.026 14.8 0.3 1.3 1 0 0 1 1 1 0 Arterivirus nucleocapsid protein PBP1_TM PF14812.6 ETO04389.1 - 0.038 14.3 21.2 0.06 13.7 21.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Utp14 PF04615.13 ETO04389.1 - 0.046 12.3 13.8 0.045 12.3 13.8 1.1 1 0 0 1 1 1 0 Utp14 protein CDC45 PF02724.14 ETO04389.1 - 0.052 11.8 14.3 0.05 11.9 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Hep_59 PF07052.11 ETO04389.1 - 0.34 11.7 8.9 0.32 11.8 7.8 1.5 1 1 1 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 GCIP PF13324.6 ETO04389.1 - 0.34 10.5 8.8 0.36 10.4 8.8 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DNA_pol_phi PF04931.13 ETO04389.1 - 0.62 8.1 17.2 0.63 8.1 17.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFB6 PF17110.5 ETO04389.1 - 2.3 8.0 8.4 2.5 7.8 8.4 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RRN3 PF05327.11 ETO04389.1 - 2.4 6.6 12.3 2.3 6.6 12.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 ETO04389.1 - 2.4 7.5 13.4 2.7 7.3 13.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sporozoite_P67 PF05642.11 ETO04389.1 - 6.9 4.6 11.0 7.3 4.5 11.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4637 PF15470.6 ETO04389.1 - 7.7 6.2 11.8 10 5.8 11.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SGT1 PF07093.11 ETO04389.1 - 7.7 4.8 13.0 7.7 4.8 13.0 1.1 1 0 0 1 1 1 0 SGT1 protein TRAP_alpha PF03896.16 ETO04389.1 - 7.9 5.6 10.2 8.2 5.5 10.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit GEN1_C PF18380.1 ETO04389.1 - 8.2 7.4 12.5 15 6.5 12.5 1.4 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Mucin PF01456.17 ETO04390.1 - 1.2 9.1 13.7 3.1 7.8 13.7 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein NUSAP PF16006.5 ETO04391.1 - 0.055 13.2 6.0 0.087 12.6 6.0 1.3 1 0 0 1 1 1 0 Nucleolar and spindle-associated protein WD40 PF00400.32 ETO04395.1 - 1.2e-37 127.2 25.0 1e-06 29.3 0.6 7.9 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04395.1 - 9.8e-14 51.4 0.2 0.33 11.3 0.0 5.9 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04395.1 - 0.006 16.0 4.0 9.5 5.4 0.0 3.8 1 1 2 4 4 4 3 WD40-like domain ubiquitin PF00240.23 ETO04397.1 - 5e-10 39.0 0.0 2e-09 37.1 0.0 2.1 1 0 0 1 1 1 1 Ubiquitin family zf-RING_UBOX PF13445.6 ETO04397.1 - 5.2e-06 26.4 4.8 0.00018 21.5 0.5 2.7 2 0 0 2 2 2 2 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO04397.1 - 7.5e-06 25.7 9.3 1.7e-05 24.6 0.5 3.2 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO04397.1 - 0.00038 20.4 8.5 0.011 15.7 3.2 2.8 2 0 0 2 2 2 2 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETO04397.1 - 0.00044 20.0 1.3 0.00044 20.0 1.3 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO04397.1 - 0.00066 19.8 6.3 0.003 17.7 0.5 3.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4_3 PF13920.6 ETO04397.1 - 0.032 14.1 0.7 0.032 14.1 0.7 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4434 PF14488.6 ETO04397.1 - 0.038 14.0 0.4 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4434) zf-RING_6 PF14835.6 ETO04397.1 - 0.18 11.7 5.9 3.4 7.6 1.1 2.7 2 0 0 2 2 2 0 zf-RING of BARD1-type protein Prok-RING_4 PF14447.6 ETO04397.1 - 0.19 11.6 5.8 0.59 10.0 0.7 2.8 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO04397.1 - 0.32 11.4 14.5 0.072 13.4 3.3 3.8 4 0 0 4 4 4 0 Ring finger domain IBR PF01485.21 ETO04397.1 - 4.3 7.6 19.8 19 5.5 0.6 3.5 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain ABC2_membrane PF01061.24 ETO04398.1 - 9.3e-05 21.9 12.8 9.3e-05 21.9 12.8 2.1 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.12 ETO04398.1 - 0.001 18.9 1.5 0.0036 17.2 1.4 2.0 1 1 0 1 1 1 1 CDR ABC transporter WD40 PF00400.32 ETO04399.1 - 7.3e-10 39.3 3.6 5.6e-08 33.3 0.4 3.5 3 1 1 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04399.1 - 3.9e-07 30.3 0.1 0.00023 21.4 0.1 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04399.1 - 0.0001 21.1 0.3 0.084 11.5 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO04399.1 - 0.0027 17.6 0.1 0.13 12.1 0.0 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO04399.1 - 0.047 12.6 0.0 0.58 9.1 0.0 2.0 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein HPS6 PF15702.5 ETO04399.1 - 0.1 10.6 0.0 0.42 8.5 0.0 1.8 1 1 0 2 2 2 0 Hermansky-Pudlak syndrome 6 protein WD40 PF00400.32 ETO04400.1 - 1.2e-08 35.4 7.4 2.1e-05 25.2 0.3 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO04400.1 - 0.0089 15.4 0.2 0.042 13.2 0.2 1.9 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO04400.1 - 0.025 13.2 0.6 0.11 11.1 0.1 1.8 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Clathrin PF00637.20 ETO04401.1 - 3.8e-66 221.3 10.5 9.5e-26 90.4 0.1 4.9 5 1 0 5 5 5 3 Region in Clathrin and VPS Clathrin_H_link PF13838.6 ETO04401.1 - 2.4e-15 56.2 0.0 8.7e-15 54.4 0.0 2.1 1 0 0 1 1 1 1 Clathrin-H-link Clathrin_propel PF01394.20 ETO04402.1 - 1e-05 25.6 0.4 0.0064 16.7 0.1 2.9 3 1 0 3 3 3 2 Clathrin propeller repeat DUF72 PF01904.18 ETO04405.1 - 0.021 14.9 0.0 0.035 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF72 Myc_N PF01056.18 ETO04407.1 - 0.0077 16.2 7.8 0.012 15.6 7.8 1.2 1 0 0 1 1 1 1 Myc amino-terminal region DUF3306 PF11748.8 ETO04407.1 - 0.067 14.1 6.2 0.12 13.2 6.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) PTPRCAP PF15713.5 ETO04407.1 - 0.13 12.5 6.6 0.27 11.5 6.6 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SID-1_RNA_chan PF13965.6 ETO04407.1 - 0.3 9.4 3.1 0.32 9.4 3.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Folate_carrier PF01770.18 ETO04407.1 - 0.7 8.6 2.0 1.2 7.8 2.0 1.4 1 0 0 1 1 1 0 Reduced folate carrier FAM176 PF14851.6 ETO04407.1 - 1.2 8.8 7.7 2.7 7.6 7.7 1.6 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 ETO04407.1 - 3.7 6.2 8.0 4.4 6.0 8.0 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO04407.1 - 6 6.0 5.3 7.7 5.6 5.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4637 PF15470.6 ETO04407.1 - 7.3 6.3 12.0 14 5.4 12.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) WD40 PF00400.32 ETO04409.1 - 4.2e-41 138.1 20.8 5.1e-07 30.3 0.4 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04409.1 - 9.1e-11 41.9 1.6 0.016 15.5 0.1 5.2 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04409.1 - 9.8e-08 31.1 8.2 0.037 12.7 0.2 4.8 1 1 3 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO04409.1 - 0.00012 22.1 3.0 0.33 11.0 0.1 4.2 3 2 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Cofilin_ADF PF00241.20 ETO04410.1 - 0.042 13.7 0.7 0.056 13.2 0.7 1.4 1 1 0 1 1 1 0 Cofilin/tropomyosin-type actin-binding protein DUF3586 PF12131.8 ETO04411.1 - 0.00038 20.6 5.2 0.026 14.7 0.7 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF3586) I-set PF07679.16 ETO04412.1 - 0.02 15.0 0.3 0.06 13.4 0.3 1.8 1 0 0 1 1 1 0 Immunoglobulin I-set domain DUF2722 PF10846.8 ETO04412.1 - 5.4 5.8 14.7 13 4.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) FKBP_N PF01346.18 ETO04414.1 - 0.011 16.7 4.3 0.017 16.1 4.3 1.3 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase RTT107_BRCT_6 PF16771.5 ETO04414.1 - 0.078 13.1 6.9 1.7 8.9 6.9 2.0 1 1 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain GFRP PF06399.13 ETO04414.1 - 0.14 12.1 0.1 0.41 10.6 0.0 1.9 2 0 0 2 2 2 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) G0-G1_switch_2 PF15103.6 ETO04414.1 - 0.46 10.9 3.8 0.66 10.4 3.5 1.5 1 1 0 1 1 1 0 G0/G1 switch protein 2 zf-C4H2 PF10146.9 ETO04415.1 - 0.00013 22.4 2.9 0.00022 21.6 2.9 1.5 1 0 0 1 1 1 1 Zinc finger-containing protein Corazonin PF17308.2 ETO04415.1 - 0.14 12.5 5.6 0.53 10.7 5.6 2.0 1 0 0 1 1 1 0 Pro-corazonin Jnk-SapK_ap_N PF09744.9 ETO04415.1 - 0.29 11.3 12.9 0.57 10.4 12.9 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Noelin-1 PF12308.8 ETO04415.1 - 0.3 11.1 2.0 0.61 10.1 1.2 1.9 1 1 0 1 1 1 0 Neurogenesis glycoprotein UPF0242 PF06785.11 ETO04415.1 - 1.8 8.6 17.3 5.4 7.1 17.3 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ubiquitin PF00240.23 ETO04416.1 - 1.2e-10 41.0 0.2 1.2e-10 41.0 0.2 2.3 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ETO04416.1 - 6.9e-06 25.8 0.1 2.5e-05 24.0 0.1 2.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETO04416.1 - 0.0011 18.9 0.0 0.0025 17.7 0.0 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain GAS PF13851.6 ETO04416.1 - 0.0014 18.1 0.7 0.0014 18.1 0.7 2.0 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding Csm1_N PF18504.1 ETO04416.1 - 0.0045 17.3 0.9 0.0045 17.3 0.9 2.8 3 0 0 3 3 2 1 Csm1 N-terminal domain DUF3972 PF13118.6 ETO04416.1 - 0.0048 17.3 0.4 0.0048 17.3 0.4 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3972) CENP-K PF11802.8 ETO04416.1 - 0.0065 16.1 1.3 0.0065 16.1 1.3 2.0 2 0 0 2 2 2 1 Centromere-associated protein K DinB PF05163.12 ETO04416.1 - 0.023 14.6 0.1 0.049 13.6 0.1 1.5 1 0 0 1 1 1 0 DinB family Syntaxin-6_N PF09177.11 ETO04416.1 - 0.028 15.0 0.6 0.1 13.2 0.6 2.0 1 0 0 1 1 1 0 Syntaxin 6, N-terminal BST2 PF16716.5 ETO04416.1 - 0.037 14.6 1.1 0.15 12.7 1.1 2.1 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 UN_NPL4 PF11543.8 ETO04416.1 - 0.075 13.5 0.0 0.22 12.1 0.0 1.8 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 SlyX PF04102.12 ETO04416.1 - 0.081 13.5 0.7 0.081 13.5 0.7 2.4 2 0 0 2 2 2 0 SlyX Spectrin PF00435.21 ETO04416.1 - 0.086 13.3 3.5 1.7 9.2 0.4 2.7 2 0 0 2 2 2 0 Spectrin repeat DUF4994 PF16385.5 ETO04416.1 - 0.095 12.6 0.3 0.4 10.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF4094 PF13334.6 ETO04416.1 - 0.14 12.6 0.5 0.53 10.7 0.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) ABC_tran_CTD PF16326.5 ETO04416.1 - 0.18 12.1 3.0 0.54 10.5 1.5 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain BRE1 PF08647.11 ETO04416.1 - 1.1 9.4 11.2 0.077 13.1 1.5 3.3 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase rve PF00665.26 ETO04417.1 - 7.4e-24 84.2 0.0 1.4e-23 83.3 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain RT_RNaseH PF17917.1 ETO04417.1 - 3.2e-16 59.5 1.9 8.6e-16 58.1 0.8 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase Integrase_H2C2 PF17921.1 ETO04417.1 - 4.4e-16 58.7 0.4 4.4e-16 58.7 0.4 2.3 3 0 0 3 3 3 1 Integrase zinc binding domain zf-H2C2 PF09337.10 ETO04417.1 - 6.7e-07 29.4 0.0 3.8e-06 27.0 0.1 2.4 2 0 0 2 2 2 1 H2C2 zinc finger rve_3 PF13683.6 ETO04417.1 - 8.9e-07 28.6 0.2 0.00015 21.5 0.0 2.8 2 0 0 2 2 2 1 Integrase core domain RT_RNaseH_2 PF17919.1 ETO04417.1 - 3.2e-05 23.9 0.2 0.00018 21.5 0.2 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase HEPN PF05168.14 ETO04417.1 - 0.0035 17.5 0.7 0.023 14.8 0.1 2.4 3 0 0 3 3 3 1 HEPN domain MLVIN_C PF18697.1 ETO04417.1 - 0.0048 17.0 0.0 0.016 15.3 0.0 1.9 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DDE_Tnp_IS240 PF13610.6 ETO04417.1 - 0.041 14.1 0.0 0.13 12.5 0.0 1.8 1 0 0 1 1 1 0 DDE domain MIF4G PF02854.19 ETO04418.1 - 5.5e-06 26.2 1.0 1.2e-05 25.0 1.0 1.6 1 0 0 1 1 1 1 MIF4G domain Adaptin_binding PF10199.9 ETO04418.1 - 0.00093 19.8 0.3 0.054 14.1 0.0 2.5 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 RP-C_C PF11800.8 ETO04418.1 - 0.48 10.5 7.2 0.18 11.9 0.3 2.6 3 0 0 3 3 3 0 Replication protein C C-terminal region MDD_C PF18376.1 ETO04419.1 - 0.038 13.7 1.8 0.056 13.2 1.8 1.2 1 0 0 1 1 1 0 Mevalonate 5-diphosphate decarboxylase C-terminal domain zf_UBZ PF18439.1 ETO04419.1 - 0.62 9.7 2.1 3.4 7.3 0.2 2.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger Ras PF00071.22 ETO04420.1 - 4e-44 150.1 0.2 4e-44 150.1 0.2 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO04420.1 - 5e-16 59.0 0.0 1.4e-15 57.6 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO04420.1 - 1.7e-07 30.9 0.1 1.7e-07 30.9 0.1 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO04420.1 - 4.9e-06 26.6 2.0 0.18 11.7 0.0 4.2 4 0 0 4 4 4 2 RsgA GTPase DUF4883 PF16224.5 ETO04420.1 - 0.12 12.6 0.9 0.58 10.4 0.9 2.1 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) MMR_HSR1 PF01926.23 ETO04420.1 - 0.37 10.9 4.1 0.41 10.7 0.8 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase DUF5081 PF16887.5 ETO04421.1 - 2 7.4 5.7 27 3.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5081) DUF4704 PF15787.5 ETO04423.1 - 1.5e-08 34.2 9.5 1.1e-07 31.5 1.6 2.7 2 1 1 3 3 3 2 Domain of unknown function (DUF4704) Beach PF02138.18 ETO04424.1 - 2.8e-108 361.5 1.6 2.8e-108 361.5 1.6 2.3 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO04424.1 - 6.9e-10 38.9 0.5 3.1e-09 36.9 0.5 2.2 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ETO04424.1 - 4.6e-07 30.4 0.3 0.00012 22.7 0.0 3.8 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF1088 PF06469.11 ETO04424.1 - 0.022 14.4 0.3 0.072 12.8 0.2 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1088) Mvb12 PF09452.10 ETO04424.1 - 1.4 9.4 9.2 0.22 12.0 1.6 3.2 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 Aa_trans PF01490.18 ETO04426.1 - 6.5e-20 71.2 18.9 7.3e-20 71.0 18.9 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2730 PF10805.8 ETO04426.1 - 0.087 12.9 0.7 0.32 11.1 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) CDC45 PF02724.14 ETO04427.1 - 0.0022 16.4 12.5 0.0022 16.4 12.5 2.7 2 1 1 3 3 3 1 CDC45-like protein Nop14 PF04147.12 ETO04427.1 - 0.29 9.3 63.2 0.23 9.6 37.8 2.1 2 0 0 2 2 2 0 Nop14-like family DUF3439 PF11921.8 ETO04427.1 - 0.41 10.6 11.8 0.98 9.4 11.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) BUD22 PF09073.10 ETO04427.1 - 2.4 7.4 67.7 0.25 10.6 43.9 2.2 2 0 0 2 2 2 0 BUD22 WD40 PF00400.32 ETO04428.1 - 4.4e-20 71.6 6.7 8.6e-08 32.7 0.5 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO04428.1 - 2.5e-06 26.4 0.7 0.063 11.9 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04428.1 - 0.00058 20.1 0.4 5 7.5 0.0 3.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_49 PF03718.13 ETO04428.1 - 0.042 13.9 0.6 0.19 11.8 0.1 2.0 2 1 0 2 2 2 0 Glycosyl hydrolase family 49 Kelch_5 PF13854.6 ETO04429.1 - 0.0039 17.2 0.1 3.2 7.9 0.0 2.7 3 0 0 3 3 3 2 Kelch motif Copper-bind PF00127.20 ETO04429.1 - 0.22 12.0 0.1 0.22 12.0 0.1 1.8 2 1 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family WD40 PF00400.32 ETO04430.1 - 7.3e-40 134.2 21.8 1e-06 29.3 0.8 7.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04430.1 - 1.3e-15 57.5 2.0 0.058 13.7 0.0 7.3 6 1 1 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04430.1 - 6.3e-15 54.8 5.3 0.0023 16.7 0.1 5.3 1 1 3 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO04430.1 - 3.2e-07 30.9 2.7 1.3e-06 29.0 2.7 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger WD40_like PF17005.5 ETO04430.1 - 1.3e-06 28.0 1.4 0.24 10.7 0.0 5.0 2 2 2 5 5 5 3 WD40-like domain DUF4407 PF14362.6 ETO04430.1 - 0.0073 15.7 4.8 0.011 15.2 4.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) E1_UFD PF09358.10 ETO04431.1 - 0.068 13.9 2.0 0.096 13.4 2.0 1.4 1 0 0 1 1 1 0 Ubiquitin fold domain DUF2681 PF10883.8 ETO04431.1 - 0.15 12.5 10.7 0.22 12.0 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) MAP17 PF15807.5 ETO04431.1 - 0.46 10.7 6.5 0.56 10.4 6.5 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Tweety PF04906.13 ETO04431.1 - 0.61 8.7 3.1 0.68 8.5 2.6 1.4 1 1 1 2 2 2 0 Tweety DUF99 PF01949.16 ETO04431.1 - 7 6.0 6.6 11 5.4 6.6 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF99 ATP-synt_C PF00137.21 ETO04432.1 - 2e-17 63.3 10.5 3.2e-17 62.6 10.5 1.3 1 0 0 1 1 1 1 ATP synthase subunit C RebB PF11747.8 ETO04432.1 - 0.12 12.5 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 Killing trait SAM_2 PF07647.17 ETO04433.1 - 2.1e-08 34.2 0.0 4.4e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO04433.1 - 2.8e-07 30.9 0.0 5.4e-07 30.0 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Shisa PF13908.6 ETO04433.1 - 0.0052 17.1 0.9 0.019 15.2 0.9 1.9 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator TPR_12 PF13424.6 ETO04434.1 - 1.6e-47 159.7 5.8 6.1e-19 68.1 0.0 5.1 2 1 2 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04434.1 - 1.5e-41 138.5 47.0 1.5e-08 34.1 1.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04434.1 - 1.6e-40 134.0 31.9 2.3e-07 30.4 0.3 7.2 6 1 1 7 7 7 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04434.1 - 1.8e-39 130.7 38.9 3.7e-07 29.8 0.5 7.2 6 1 1 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04434.1 - 8.9e-35 116.2 13.2 3.9e-05 23.4 0.1 7.1 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04434.1 - 1.9e-34 116.6 0.7 6.3e-07 29.1 0.1 7.2 6 1 1 7 7 7 6 Tetratricopeptide repeat TPR_6 PF13174.6 ETO04434.1 - 4.2e-15 55.3 8.8 0.046 14.4 0.0 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO04434.1 - 5.1e-15 55.8 0.0 0.0076 16.9 0.0 5.7 5 2 1 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO04434.1 - 6.8e-14 51.4 0.0 0.028 15.2 0.0 6.9 4 2 3 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO04434.1 - 5.8e-13 48.3 15.4 0.016 15.6 0.3 6.7 6 2 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO04434.1 - 5.6e-11 41.9 52.4 0.006 16.2 0.7 10.3 6 3 4 10 10 10 6 TPR repeat TPR_3 PF07720.12 ETO04434.1 - 1.2e-09 38.0 27.1 0.046 13.7 0.4 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat MIT PF04212.18 ETO04434.1 - 1.8e-07 31.1 29.6 0.23 11.5 0.7 6.3 5 1 1 6 6 6 4 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO04434.1 - 3.3e-07 30.7 4.7 0.0067 16.9 0.1 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO04434.1 - 8.7e-07 29.0 0.0 0.0048 17.0 0.0 4.5 5 1 1 6 6 6 1 Tetratricopeptide repeat DUF4810 PF16068.5 ETO04434.1 - 2.9e-06 27.7 3.0 1 9.9 0.0 5.2 5 1 0 5 5 5 1 Domain of unknown function (DUF4810) SHNi-TPR PF10516.9 ETO04434.1 - 0.0056 16.1 9.4 4.4 6.8 0.0 5.8 6 0 0 6 6 6 1 SHNi-TPR Sel1 PF08238.12 ETO04434.1 - 0.0071 17.0 16.9 21 6.0 0.0 7.1 7 2 0 7 7 7 0 Sel1 repeat UBA_6 PF18039.1 ETO04434.1 - 0.014 15.3 1.5 0.11 12.5 0.1 3.0 4 0 0 4 4 4 0 UBA-like domain DUF5113 PF17140.4 ETO04434.1 - 0.015 15.1 17.3 0.41 10.4 0.1 5.1 3 1 1 5 5 5 0 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETO04434.1 - 0.029 13.7 0.0 0.14 11.5 0.0 2.0 2 1 1 3 3 3 0 MalT-like TPR region PPR PF01535.20 ETO04434.1 - 0.034 14.4 10.1 5.8 7.4 0.0 5.8 7 0 0 7 7 6 0 PPR repeat DUF2802 PF10975.8 ETO04434.1 - 0.18 11.9 1.6 17 5.6 0.1 3.4 4 1 0 4 4 3 0 Protein of unknown function (DUF2802) Fis1_TPR_C PF14853.6 ETO04434.1 - 0.85 9.7 24.3 7.6 6.7 0.4 6.3 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Clathrin PF00637.20 ETO04434.1 - 1 9.3 25.6 1 9.2 7.0 4.5 3 2 1 4 4 4 0 Region in Clathrin and VPS SPO22 PF08631.10 ETO04434.1 - 2 7.8 12.0 37 3.7 0.3 5.0 4 2 2 6 6 6 0 Meiosis protein SPO22/ZIP4 like Pep3_Vps18 PF05131.14 ETO04434.1 - 8.1 6.2 8.6 44 3.9 0.0 4.8 4 1 2 6 6 6 0 Pep3/Vps18/deep orange family STPPase_N PF16891.5 ETO04437.1 - 3.3e-17 62.7 0.8 6.6e-17 61.7 0.8 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain CAP_N PF01213.19 ETO04437.1 - 0.012 15.1 2.0 0.02 14.4 2.0 1.4 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal FSA_C PF10479.9 ETO04437.1 - 0.38 8.8 18.1 0.49 8.5 18.1 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Metallophos PF00149.28 ETO04438.1 - 1.5e-15 58.2 0.0 2.7e-15 57.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase GGDEF PF00990.21 ETO04438.1 - 0.0059 16.4 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain UPF0060 PF02694.15 ETO04438.1 - 0.011 16.0 3.9 0.02 15.1 1.2 2.2 2 0 0 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family RVT_1 PF00078.27 ETO04439.1 - 0.0011 18.6 0.0 0.003 17.1 0.0 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-3CxxC_2 PF17180.4 ETO04439.1 - 0.03 15.0 1.2 0.19 12.5 0.7 2.7 2 0 0 2 2 2 0 Zinc-binding domain Nucleocapsid-N PF11030.8 ETO04440.1 - 1 9.3 7.2 0.064 13.2 0.8 2.1 1 1 1 2 2 2 0 Nucleocapsid protein N CENP-B_dimeris PF09026.10 ETO04441.1 - 0.021 15.2 3.3 1.3 9.5 0.4 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Kinesin PF00225.23 ETO04442.1 - 1.1e-21 77.2 1.2 1.5e-21 76.7 1.2 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO04442.1 - 1.1e-17 64.3 2.6 1.8e-17 63.7 2.6 1.2 1 0 0 1 1 1 1 Microtubule binding Peptidase_C93 PF06035.11 ETO04442.1 - 0.0095 15.7 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 1 Bacterial transglutaminase-like cysteine proteinase BTLCP DUF4551 PF15087.6 ETO04443.1 - 0.051 12.4 2.4 0.063 12.1 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CAP_N PF01213.19 ETO04443.1 - 4.2 6.8 10.8 6.3 6.2 10.8 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Chromo PF00385.24 ETO04444.1 - 4.7e-11 42.4 3.1 4.7e-11 42.4 3.1 2.0 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain DUF481 PF04338.12 ETO04444.1 - 0.073 13.1 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF481 Clostridium_P47 PF06597.11 ETO04444.1 - 1.8 7.2 10.3 0.3 9.8 3.7 2.0 1 1 1 2 2 2 0 Clostridium P-47 protein DUF1062 PF06353.12 ETO04444.1 - 7.3 7.4 16.2 20 6.0 4.7 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1062) Chromo PF00385.24 ETO04445.1 - 0.011 15.6 1.2 0.024 14.6 1.2 1.6 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain GBP_C PF02841.14 ETO04445.1 - 0.16 11.3 9.3 0.24 10.8 9.3 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Menin PF05053.13 ETO04445.1 - 1.6 7.0 11.9 2 6.7 11.9 1.1 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO04445.1 - 2.3 7.0 8.8 3 6.6 8.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Ras PF00071.22 ETO04447.1 - 9.9e-48 161.8 0.0 1.3e-47 161.4 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO04447.1 - 2.5e-17 63.2 0.0 8.7e-17 61.5 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO04447.1 - 1.3e-07 31.2 0.0 1.8e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Amidohydro_2 PF04909.14 ETO04449.1 - 8.6e-24 84.8 0.0 1.4e-23 84.1 0.0 1.3 1 1 0 1 1 1 1 Amidohydrolase Exonuc_VII_S PF02609.16 ETO04449.1 - 0.21 11.7 0.0 0.38 10.9 0.0 1.3 1 0 0 1 1 1 0 Exonuclease VII small subunit TLD PF07534.16 ETO04450.1 - 9e-11 42.2 0.3 2e-10 41.1 0.3 1.6 1 0 0 1 1 1 1 TLD Med2 PF11214.8 ETO04450.1 - 0.035 14.3 3.4 0.094 12.9 3.4 1.7 1 0 0 1 1 1 0 Mediator complex subunit 2 DUF2487 PF10673.9 ETO04450.1 - 0.042 13.9 0.6 7.2 6.6 0.0 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2487) DASH_Duo1 PF08651.10 ETO04450.1 - 0.19 11.5 7.1 0.51 10.1 1.8 2.8 3 0 0 3 3 3 0 DASH complex subunit Duo1 Agenet PF05641.12 ETO04451.1 - 4.3e-05 23.9 0.1 0.0001 22.7 0.1 1.7 1 0 0 1 1 1 1 Agenet domain TMEM144 PF07857.12 ETO04451.1 - 0.38 9.7 0.7 1 8.2 0.0 1.8 2 0 0 2 2 2 0 Transmembrane family, TMEM144 of transporters 60KD_IMP PF02096.20 ETO04452.1 - 1.2e-12 48.0 1.5 1.2e-12 48.0 1.5 1.6 2 0 0 2 2 2 1 60Kd inner membrane protein CaMKII_AD PF08332.10 ETO04453.1 - 0.13 12.4 1.1 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Calcium/calmodulin dependent protein kinase II association domain WD40 PF00400.32 ETO04454.1 - 5.1e-19 68.3 16.2 3.4e-07 30.8 1.5 5.0 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO04454.1 - 2.8e-09 36.2 0.1 0.079 11.6 0.0 4.1 3 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04454.1 - 9.1e-06 25.9 0.1 0.15 12.4 0.0 3.8 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Glyco_transf_8 PF01501.20 ETO04457.1 - 0.00011 21.9 1.7 0.004 16.7 1.7 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Mannosyl_trans3 PF11051.8 ETO04457.1 - 0.00041 19.8 0.2 0.0012 18.3 0.2 1.9 1 1 0 1 1 1 1 Mannosyltransferase putative Ribosomal_L7Ae PF01248.26 ETO04457.1 - 0.014 15.1 0.0 0.031 14.0 0.0 1.6 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Mitoc_mL59 PF18126.1 ETO04460.1 - 0.00053 20.3 0.0 0.00072 19.9 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal protein mL59 WD40 PF00400.32 ETO04462.1 - 0.0026 18.5 0.6 0.0062 17.4 0.6 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat HHH_6 PF14579.6 ETO04463.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif EMP24_GP25L PF01105.24 ETO04465.1 - 0.014 15.3 0.2 0.014 15.3 0.2 1.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Phage_connect_1 PF05135.13 ETO04465.1 - 0.06 13.9 0.9 0.15 12.5 0.2 2.0 2 0 0 2 2 2 0 Phage gp6-like head-tail connector protein DUF2098 PF09871.9 ETO04465.1 - 0.065 13.6 0.3 0.065 13.6 0.3 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) PVL_ORF50 PF07768.11 ETO04465.1 - 0.066 13.5 2.7 0.88 9.9 0.1 2.2 2 0 0 2 2 2 0 PVL ORF-50-like family DHR10 PF18595.1 ETO04465.1 - 0.099 12.7 5.2 7 6.7 2.7 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain RasGAP_C PF03836.15 ETO04465.1 - 0.11 12.6 5.4 0.12 12.5 1.3 2.3 2 0 0 2 2 2 0 RasGAP C-terminus Lebercilin PF15619.6 ETO04465.1 - 0.4 10.3 8.0 0.37 10.4 1.3 2.2 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Jnk-SapK_ap_N PF09744.9 ETO04465.1 - 1.3 9.2 8.9 0.43 10.8 4.3 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF1947 PF09183.10 ETO04467.1 - 0.21 11.9 0.1 0.21 11.9 0.1 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF1947) HypA PF01155.19 ETO04467.1 - 0.72 9.9 4.6 7.2 6.7 0.6 2.2 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF3391 PF11871.8 ETO04467.1 - 1 9.9 6.5 0.22 12.1 2.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) SecA_DEAD PF07517.14 ETO04468.1 - 1.7e-06 27.6 0.0 1.7e-06 27.6 0.0 4.1 5 1 0 5 5 5 1 SecA DEAD-like domain CotJB PF12652.7 ETO04468.1 - 2 8.7 5.4 4.6 7.5 0.1 4.0 3 0 0 3 3 3 0 CotJB protein Activator-TraM PF11657.8 ETO04468.1 - 2.6 7.9 10.8 0.089 12.6 1.3 3.4 4 0 0 4 4 4 0 Transcriptional activator TraM RseC_MucC PF04246.12 ETO04470.1 - 7.9 6.4 7.1 0.2 11.6 0.3 1.8 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC GlcNAc PF11397.8 ETO04471.1 - 1.4e-28 100.4 1.6 1.7e-28 100.1 1.6 1.1 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) WD40 PF00400.32 ETO04473.1 - 1.2e-17 64.0 5.0 6.7e-07 29.9 0.4 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04473.1 - 0.00027 21.2 0.0 0.11 12.8 0.0 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04473.1 - 0.0037 16.0 0.0 0.052 12.2 0.1 2.1 2 0 0 2 2 2 1 Nucleoporin Nup120/160 DUF624 PF04854.14 ETO04473.1 - 0.16 12.1 5.1 0.63 10.2 3.8 2.6 2 1 0 2 2 2 0 Protein of unknown function, DUF624 Kelch_6 PF13964.6 ETO04475.1 - 0.013 15.8 0.2 8.5 6.8 0.0 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ETO04475.1 - 0.082 12.9 0.3 18 5.5 0.0 3.9 5 0 0 5 5 5 0 Galactose oxidase, central domain zf-RRPl_C4 PF17026.5 ETO04476.1 - 0.017 15.2 1.2 0.018 15.1 1.2 1.1 1 0 0 1 1 1 0 Putative ribonucleoprotein zinc-finger pf C4 type DUF3293 PF11697.8 ETO04476.1 - 0.06 13.8 0.1 0.11 12.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3293) zf-C6H2 PF15801.5 ETO04476.1 - 0.5 10.7 3.9 1.7 9.0 0.2 2.2 1 1 1 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding WD40 PF00400.32 ETO04477.1 - 7.8e-56 184.8 14.8 1.5e-10 41.4 0.3 7.8 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04477.1 - 2e-23 82.5 0.6 0.0034 17.6 0.0 7.2 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04477.1 - 4.1e-16 58.8 1.1 0.00028 19.9 0.0 5.8 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO04477.1 - 1.5e-09 37.6 5.1 0.41 10.6 0.1 6.9 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO04477.1 - 4.6e-09 36.4 0.1 0.035 14.0 0.0 4.2 1 1 4 5 5 5 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO04477.1 - 7.6e-09 34.6 1.2 0.00011 20.9 0.3 3.8 2 1 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO04477.1 - 1.6e-08 33.7 10.0 0.1 11.2 0.1 5.9 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO04477.1 - 2.2e-06 27.2 0.1 0.78 9.0 0.0 4.0 2 2 2 4 4 4 3 WD40-like domain DPPIV_N PF00930.21 ETO04477.1 - 0.00019 20.3 0.0 6.5 5.4 0.0 4.3 1 1 3 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO04477.1 - 0.00044 20.3 4.7 0.65 10.1 0.1 4.6 2 2 3 5 5 5 1 Family of unknown function (DUF5570) Str_synth PF03088.16 ETO04477.1 - 0.00064 19.8 0.1 0.043 13.9 0.0 3.6 4 2 2 6 6 6 1 Strictosidine synthase SGL PF08450.12 ETO04477.1 - 0.0024 17.5 0.5 1.7 8.1 0.0 3.0 1 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region PALB2_WD40 PF16756.5 ETO04477.1 - 0.0055 15.7 4.8 9.8 5.0 0.0 4.6 2 2 4 6 6 6 1 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO04477.1 - 0.019 14.3 1.0 10 5.3 0.0 3.9 1 1 2 4 4 4 0 Neuroblastoma-amplified sequence, N terminal TruB_C PF09142.11 ETO04477.1 - 0.18 11.6 0.0 0.84 9.5 0.0 2.1 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal DUF5051 PF16473.5 ETO04479.1 - 9.7e-09 35.4 0.4 2e-08 34.4 0.4 1.5 1 0 0 1 1 1 1 3' exoribonuclease, RNase T-like Caldesmon PF02029.15 ETO04479.1 - 0.00092 18.1 2.1 0.0011 17.8 2.1 1.1 1 0 0 1 1 1 1 Caldesmon Trypan_PARP PF05887.11 ETO04479.1 - 0.0027 17.7 6.0 0.0056 16.7 6.0 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) DNA_pol_A_exo1 PF01612.20 ETO04479.1 - 0.0074 16.0 5.0 0.07 12.8 2.2 2.9 2 1 1 3 3 3 1 3'-5' exonuclease Ndc1_Nup PF09531.10 ETO04479.1 - 0.062 12.0 2.8 0.075 11.7 2.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Tristanin_u2 PF16638.5 ETO04479.1 - 2.8 8.8 8.2 2.3 9.1 6.4 1.8 1 1 1 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers SAM_2 PF07647.17 ETO04482.1 - 0.00016 21.7 0.2 0.0012 19.0 0.2 2.5 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) Aida_N PF08910.10 ETO04482.1 - 0.032 14.6 0.1 0.11 12.9 0.1 1.9 1 0 0 1 1 1 0 Aida N-terminus SAM_1 PF00536.30 ETO04482.1 - 0.05 14.0 0.3 0.19 12.2 0.1 2.2 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) TPR_12 PF13424.6 ETO04483.1 - 8.4e-21 74.1 3.5 7.6e-13 48.6 1.1 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04483.1 - 3e-13 49.2 0.1 0.00018 21.3 0.0 3.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04483.1 - 2.5e-12 45.9 0.4 0.0026 17.7 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04483.1 - 1.8e-11 43.3 5.8 0.00042 20.0 2.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04483.1 - 1.7e-09 37.0 3.9 0.0063 16.5 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04483.1 - 3.2e-09 36.3 5.1 0.0074 16.4 1.5 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat SNAP PF14938.6 ETO04483.1 - 4.1e-07 29.7 0.2 4.7e-07 29.5 0.2 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO04483.1 - 5.7e-06 25.9 1.7 3.3 7.5 0.0 4.3 3 2 1 4 4 4 3 TPR repeat TPR_6 PF13174.6 ETO04483.1 - 0.0078 16.8 0.0 8.5 7.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO04483.1 - 0.025 13.9 0.1 0.027 13.9 0.1 1.1 1 0 0 1 1 1 0 MalT-like TPR region RPN7 PF10602.9 ETO04483.1 - 0.038 13.7 1.1 2.5 7.8 0.0 2.3 1 1 1 2 2 2 0 26S proteasome subunit RPN7 DUF5113 PF17140.4 ETO04483.1 - 0.074 12.8 3.5 0.058 13.2 1.2 1.9 1 1 2 3 3 3 0 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETO04483.1 - 0.11 12.9 1.3 1.3 9.6 0.1 3.0 4 0 0 4 4 3 0 Tetratricopeptide repeat NSF PF02071.20 ETO04483.1 - 1.2 10.2 5.1 8.9 7.6 0.2 3.9 5 0 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat PCNA_C PF02747.15 ETO04484.1 - 1.3e-47 161.2 0.0 3.2e-47 159.9 0.0 1.6 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 ETO04484.1 - 4.6e-44 149.2 1.9 7.8e-44 148.5 1.9 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.16 ETO04484.1 - 3.6e-06 26.2 0.2 6.3e-05 22.2 0.2 2.4 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 ETO04484.1 - 0.00099 18.6 0.0 0.0012 18.3 0.0 1.2 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 ETO04484.1 - 0.014 14.5 0.0 0.026 13.6 0.0 1.4 1 1 0 1 1 1 0 Hus1-like protein Rap_GAP PF02145.15 ETO04486.1 - 6.1e-45 153.0 0.0 1.7e-44 151.6 0.0 1.9 1 0 0 1 1 1 1 Rap/ran-GAP UPF0565 PF10561.9 ETO04487.1 - 1.1e-33 116.8 10.7 1.3e-17 63.9 5.3 3.2 2 1 1 3 3 3 3 Uncharacterised protein family UPF0565 NB-LRR PF12061.8 ETO04487.1 - 0.034 13.5 0.3 0.064 12.6 0.3 1.5 1 0 0 1 1 1 0 Late blight resistance protein R1 TipE PF16972.5 ETO04487.1 - 0.73 8.9 16.3 1.1 8.3 16.3 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE DNA_pol_phi PF04931.13 ETO04487.1 - 1 7.4 11.5 2.6 6.0 0.0 2.2 2 0 0 2 2 2 0 DNA polymerase phi NOA36 PF06524.12 ETO04487.1 - 2.1 7.6 8.2 4.6 6.5 8.2 1.5 1 0 0 1 1 1 0 NOA36 protein Malt_amylase_C PF16657.5 ETO04488.1 - 0.061 13.4 0.0 1.3 9.2 0.0 2.4 2 0 0 2 2 2 0 Maltogenic Amylase, C-terminal domain TPR_12 PF13424.6 ETO04489.1 - 1.6e-23 82.8 2.2 8.8e-12 45.1 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04489.1 - 5.1e-15 54.8 0.5 4.7e-07 29.5 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04489.1 - 6.8e-12 44.7 22.6 1.7e-07 30.8 2.3 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04489.1 - 3.1e-10 39.4 7.0 8e-05 22.4 0.1 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04489.1 - 2.4e-09 36.6 23.7 0.00058 19.8 1.6 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04489.1 - 2.5e-09 36.6 22.2 0.00063 19.8 0.8 5.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO04489.1 - 2.8e-06 27.3 2.0 0.00054 20.2 0.3 3.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO04489.1 - 0.00017 22.2 0.0 0.86 10.3 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO04489.1 - 0.00078 19.1 5.1 0.23 11.1 0.4 3.6 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.6 ETO04489.1 - 0.0025 18.3 5.4 1 10.1 0.1 3.5 4 0 0 4 4 3 2 Tetratricopeptide repeat SPO22 PF08631.10 ETO04489.1 - 0.0034 16.9 4.4 0.035 13.6 1.1 2.7 1 1 1 2 2 2 1 Meiosis protein SPO22/ZIP4 like DTHCT PF08070.11 ETO04489.1 - 0.11 13.2 1.7 0.36 11.6 1.7 1.8 1 0 0 1 1 1 0 DTHCT (NUC029) region ANAPC3 PF12895.7 ETO04489.1 - 0.12 12.6 3.6 2.7 8.3 0.6 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4199 PF13858.6 ETO04489.1 - 0.27 11.6 0.7 0.93 9.9 0.7 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) WD40 PF00400.32 ETO04491.1 - 5.2e-13 49.2 10.4 1e-06 29.3 0.9 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04491.1 - 3.8e-06 25.8 0.4 0.0043 15.8 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04491.1 - 0.011 16.0 0.0 0.19 12.1 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain EPOP PF15223.6 ETO04492.1 - 0.019 14.4 1.8 0.025 14.0 0.2 1.7 1 1 1 2 2 2 0 Elongin BC and Polycomb repressive complex 2-associated protein TPR_12 PF13424.6 ETO04494.1 - 1.7e-14 53.8 2.0 2.3e-10 40.6 0.2 2.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04494.1 - 1.2e-12 47.0 5.2 5.7e-07 29.1 0.5 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04494.1 - 7e-11 41.4 9.3 1.4e-05 24.8 0.1 3.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04494.1 - 3e-10 39.5 6.8 0.00011 22.1 0.5 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04494.1 - 3.4e-08 32.9 0.8 4.2e-05 23.3 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04494.1 - 3.5e-08 33.1 0.0 0.0015 18.4 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO04494.1 - 2.5e-05 24.2 7.2 0.00033 20.7 1.8 2.8 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 ETO04494.1 - 3.6e-05 24.2 0.0 0.4 11.6 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO04494.1 - 0.00087 19.8 1.8 0.43 11.3 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat SPO22 PF08631.10 ETO04494.1 - 0.0026 17.3 0.6 0.0033 16.9 0.6 1.2 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_17 PF13431.6 ETO04494.1 - 0.0054 17.0 4.8 1.1 9.8 0.0 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO04494.1 - 0.06 13.9 0.0 0.29 11.7 0.0 2.0 2 1 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ETO04496.1 - 1.2e-08 35.5 10.0 1.2e-06 29.1 2.7 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat TPR_17 PF13431.6 ETO04496.1 - 0.0059 16.9 0.0 0.012 15.9 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 ETO04496.1 - 0.049 13.9 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Caldesmon PF02029.15 ETO04498.1 - 0.014 14.2 22.4 0.017 13.9 22.4 1.0 1 0 0 1 1 1 0 Caldesmon SAPS PF04499.15 ETO04498.1 - 0.018 13.9 10.4 0.023 13.5 10.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 ETO04498.1 - 0.048 12.7 12.8 0.059 12.4 12.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 ETO04498.1 - 0.26 10.2 4.1 0.29 10.1 4.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DDHD PF02862.17 ETO04498.1 - 0.27 11.3 4.8 0.33 11.1 4.8 1.2 1 0 0 1 1 1 0 DDHD domain DUF4407 PF14362.6 ETO04498.1 - 0.86 8.9 6.9 1 8.7 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Paramyxo_ncap PF00973.19 ETO04498.1 - 2.3 7.0 10.6 2.9 6.7 10.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2151 PF10221.9 ETO04498.1 - 3.8 6.0 15.3 4.5 5.8 15.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF5523 PF17661.1 ETO04498.1 - 4.1 7.0 24.9 5.2 6.7 24.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Sec10 PF07393.11 ETO04498.1 - 4.7 5.5 15.0 6 5.1 15.0 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec10 NPR3 PF03666.13 ETO04498.1 - 5.8 5.6 15.8 6.8 5.4 15.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MCM_bind PF09739.9 ETO04498.1 - 7 5.0 13.1 8.6 4.7 13.1 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor FAM60A PF15396.6 ETO04498.1 - 7.5 6.5 15.5 5.3 7.0 13.9 1.5 1 1 0 1 1 1 0 Protein Family FAM60A RP-C_C PF11800.8 ETO04498.1 - 8 6.5 9.9 11 6.0 9.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region CDC45 PF02724.14 ETO04498.1 - 8.2 4.6 18.1 10 4.3 18.1 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO04498.1 - 8.3 6.1 19.8 12 5.6 19.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Ank_3 PF13606.6 ETO04499.1 - 1.1e-07 31.6 0.2 5.4e-05 23.3 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_2 PF12796.7 ETO04499.1 - 1.7e-07 31.7 0.2 8.8e-07 29.4 0.2 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO04499.1 - 3.7e-07 30.6 0.1 0.00078 20.0 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO04499.1 - 9.6e-07 29.0 0.2 2.3e-05 24.6 0.1 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETO04499.1 - 0.00023 21.4 0.1 0.00044 20.5 0.1 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) TPR_12 PF13424.6 ETO04504.1 - 9.4e-19 67.5 0.4 5.3e-09 36.2 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04504.1 - 1.1e-10 41.0 0.1 0.00014 21.6 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04504.1 - 7e-09 35.1 0.1 0.0014 18.5 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04504.1 - 1.4e-08 34.2 10.6 9.5e-06 25.2 0.2 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04504.1 - 6.6e-07 29.0 4.5 0.0012 18.8 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04504.1 - 8.3e-05 22.5 13.5 0.002 18.2 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO04504.1 - 0.041 13.6 3.8 0.23 11.2 0.0 2.8 3 0 0 3 3 3 0 TPR repeat DUF1194 PF06707.11 ETO04504.1 - 0.043 13.0 0.3 0.097 11.9 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1194) SLT PF01464.20 ETO04504.1 - 0.9 9.2 3.2 4.5 7.0 0.0 3.0 3 0 0 3 3 3 0 Transglycosylase SLT domain SelK_SelG PF10961.8 ETO04505.1 - 2 9.1 5.9 0.4 11.3 0.7 2.1 2 1 0 2 2 2 0 Selenoprotein SelK_SelG DUF2072 PF09845.9 ETO04506.1 - 0.034 14.4 2.4 0.22 11.8 0.1 2.0 2 0 0 2 2 2 0 Zn-ribbon containing protein RVT_1 PF00078.27 ETO04508.1 - 2.3e-13 50.2 0.1 3.7e-13 49.5 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SBP_bac_3 PF00497.20 ETO04508.1 - 0.035 13.5 0.0 0.051 13.0 0.0 1.2 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 3 Glyco_hydro_98M PF08306.11 ETO04508.1 - 0.049 12.9 0.0 0.073 12.3 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 Iron_permease PF04120.12 ETO04509.1 - 0.33 10.7 4.0 1.5 8.6 4.0 2.2 1 1 0 1 1 1 0 Low affinity iron permease TnpV PF14198.6 ETO04509.1 - 2.6 8.1 12.8 2.4 8.2 5.1 3.0 3 0 0 3 3 3 0 Transposon-encoded protein TnpV WD40 PF00400.32 ETO04510.1 - 5e-39 131.6 11.9 9.6e-10 38.9 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04510.1 - 1.5e-08 34.8 0.5 0.027 14.8 0.0 3.7 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04510.1 - 2.2e-08 33.8 1.2 0.0027 17.1 0.1 2.6 2 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO04510.1 - 3.1e-07 29.7 0.3 0.021 13.8 0.0 3.7 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO04510.1 - 4.9e-05 22.2 3.0 0.1 11.2 0.2 3.5 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO04510.1 - 0.00022 20.6 0.7 0.019 14.3 0.1 2.7 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO04510.1 - 0.0048 16.8 4.7 0.36 10.8 0.2 3.4 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO04510.1 - 0.0058 15.4 4.5 0.42 9.3 0.3 2.8 1 1 1 2 2 2 2 Nup133 N terminal like POLO_box PF00659.18 ETO04510.1 - 0.02 15.1 5.1 18 5.6 0.0 3.9 4 1 0 4 4 4 0 POLO box duplicated region Inh PF02974.14 ETO04510.1 - 0.073 13.2 0.4 9.7 6.3 0.0 3.4 1 1 3 4 4 4 0 Protease inhibitor Inh AcetylCoA_hyd_C PF13336.6 ETO04510.1 - 0.074 13.0 0.1 0.91 9.4 0.0 2.4 1 1 2 3 3 3 0 Acetyl-CoA hydrolase/transferase C-terminal domain DUF1611_N PF17396.2 ETO04510.1 - 0.15 12.3 0.0 0.46 10.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_N) Rossmann-like domain DUF4999 PF16390.5 ETO04510.1 - 0.4 10.9 1.6 61 4.0 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function RabGAP-TBC PF00566.18 ETO04511.1 - 7e-32 110.8 0.7 9.4e-32 110.4 0.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LPD23 PF18838.1 ETO04511.1 - 0.041 13.7 0.0 0.073 12.8 0.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 23 Dynein_light PF01221.18 ETO04512.1 - 3.6e-37 126.5 1.6 3.6e-37 126.5 1.6 2.4 2 0 0 2 2 2 1 Dynein light chain type 1 KdpC PF02669.15 ETO04512.1 - 0.0049 16.7 0.7 0.12 12.1 0.4 2.2 2 0 0 2 2 2 1 K+-transporting ATPase, c chain Actin PF00022.19 ETO04513.1 - 1.6e-16 60.0 0.0 5.7e-10 38.4 0.0 2.2 2 0 0 2 2 2 2 Actin DUF365 PF04033.12 ETO04513.1 - 0.1 12.9 0.2 0.37 11.1 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF365) Peptidase_C50 PF03568.17 ETO04514.1 - 0.12 11.5 2.7 0.17 11.0 2.6 1.4 1 1 0 1 1 1 0 Peptidase family C50 Ras PF00071.22 ETO04515.1 - 1.9e-06 27.5 0.6 4.5e-06 26.3 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO04515.1 - 0.028 14.6 0.3 0.13 12.5 0.0 2.1 1 1 2 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase FAO_M PF16350.5 ETO04515.1 - 0.21 11.9 0.0 0.49 10.8 0.0 1.6 1 0 0 1 1 1 0 FAD dependent oxidoreductase central domain TPP1 PF10341.9 ETO04516.1 - 0.0064 16.4 0.0 0.0085 16.1 0.0 1.2 1 0 0 1 1 1 1 Shelterin complex subunit, TPP1/ACD DUF4188 PF13826.6 ETO04516.1 - 0.14 12.5 0.1 0.31 11.4 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4188) DUF1840 PF08895.11 ETO04517.1 - 0.34 11.2 4.8 0.36 11.2 4.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) Zip PF02535.22 ETO04517.1 - 0.52 9.5 1.2 0.47 9.6 1.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter ArgoL2 PF16488.5 ETO04519.1 - 0.43 11.0 1.9 1.1 9.6 0.3 2.6 2 1 0 2 2 2 0 Argonaute linker 2 domain DUF896 PF05979.12 ETO04520.1 - 0.28 11.1 6.5 0.19 11.6 1.6 2.7 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) RNase_H PF00075.24 ETO04522.1 - 8.2e-06 26.1 0.0 1.4e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 ETO04522.1 - 1.5e-05 25.6 0.2 1.5e-05 25.6 0.2 2.8 2 2 0 2 2 2 1 zinc-binding in reverse transcriptase Telomere_Sde2_2 PF13297.6 ETO04523.1 - 4e-24 84.0 0.1 8.2e-24 83.0 0.1 1.6 1 0 0 1 1 1 1 Telomere stability C-terminal Menin PF05053.13 ETO04523.1 - 0.94 7.8 5.3 1.3 7.3 5.3 1.1 1 0 0 1 1 1 0 Menin SET PF00856.28 ETO04525.1 - 2.3e-09 37.9 0.1 3.6e-09 37.2 0.1 1.4 1 0 0 1 1 1 1 SET domain SURNod19 PF07712.12 ETO04525.1 - 0.0036 16.1 0.3 0.0056 15.5 0.3 1.2 1 0 0 1 1 1 1 Stress up-regulated Nod 19 Ribosomal_L23 PF00276.20 ETO04525.1 - 0.17 12.2 0.0 9 6.7 0.0 2.3 2 0 0 2 2 2 0 Ribosomal protein L23 bZIP_1 PF00170.21 ETO04526.1 - 0.0028 17.7 1.7 0.0028 17.7 1.7 4.2 4 1 1 5 5 5 1 bZIP transcription factor Lebercilin PF15619.6 ETO04526.1 - 0.061 13.0 18.5 0.55 9.9 8.7 2.9 2 2 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease DUF465 PF04325.13 ETO04526.1 - 0.061 13.4 0.0 0.061 13.4 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF465) ALMT PF11744.8 ETO04526.1 - 0.09 11.6 13.6 0.11 11.3 13.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter TolA_bind_tri PF16331.5 ETO04526.1 - 0.19 11.9 7.4 0.86 9.7 0.3 2.8 3 1 0 3 3 2 0 TolA binding protein trimerisation DASH_Dam1 PF08653.10 ETO04526.1 - 0.28 11.0 3.8 2.6 7.9 1.1 2.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 HMG_box_5 PF14887.6 ETO04526.1 - 0.49 10.4 7.1 3.7 7.6 1.5 2.7 2 1 0 2 2 2 0 HMG (high mobility group) box 5 SeleniumBinding PF11524.8 ETO04526.1 - 0.52 10.8 0.1 0.52 10.8 0.1 2.5 3 0 0 3 3 3 0 Selenium binding protein PGK PF00162.19 ETO04526.1 - 0.84 8.5 7.0 0.47 9.4 4.3 1.7 1 1 1 2 2 2 0 Phosphoglycerate kinase YabA PF06156.13 ETO04526.1 - 1.5 9.5 20.1 0.067 13.8 2.4 3.3 1 1 2 3 3 3 0 Initiation control protein YabA zf-CRD PF17979.1 ETO04526.1 - 1.6 8.9 10.1 0.072 13.2 2.9 2.3 1 1 2 3 3 3 0 Cysteine rich domain with multizinc binding regions Tropomyosin_1 PF12718.7 ETO04526.1 - 4.7 7.3 21.6 0.068 13.3 1.2 2.7 2 1 0 2 2 2 0 Tropomyosin like Fzo_mitofusin PF04799.13 ETO04526.1 - 5 6.7 11.9 2.7 7.5 0.4 2.7 1 1 2 3 3 3 0 fzo-like conserved region TSC22 PF01166.18 ETO04526.1 - 6.6 7.1 12.8 13 6.2 0.4 4.2 3 2 1 4 4 4 0 TSC-22/dip/bun family WD40 PF00400.32 ETO04527.1 - 1.1e-15 57.7 8.8 0.00015 22.5 0.1 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04527.1 - 2.5e-05 24.5 0.2 0.0062 16.8 0.0 3.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04527.1 - 0.022 13.4 0.4 0.12 11.0 0.2 2.1 2 1 0 2 2 2 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO04528.1 - 6.2e-117 378.1 59.2 1.1e-08 35.6 0.2 16.6 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04528.1 - 4.3e-18 65.4 17.5 0.25 11.7 0.1 11.0 1 1 9 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO04528.1 - 1.5e-08 34.7 0.0 2.8e-08 33.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO04528.1 - 2.6e-07 30.1 2.0 5e-07 29.2 2.0 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) WD40_like PF17005.5 ETO04528.1 - 7.2e-07 28.8 60.0 0.00026 20.4 0.2 9.8 2 1 9 11 11 11 7 WD40-like domain Pentapeptide_4 PF13599.6 ETO04528.1 - 6.5e-05 23.0 0.3 0.00017 21.7 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO04528.1 - 0.0036 17.4 0.7 0.0096 16.1 0.7 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) POLO_box PF00659.18 ETO04528.1 - 0.0076 16.4 14.5 21 5.4 0.0 8.4 8 1 0 8 8 8 0 POLO box duplicated region AAA_18 PF13238.6 ETO04528.1 - 0.07 13.7 0.0 0.07 13.7 0.0 4.0 4 0 0 4 4 4 0 AAA domain PD40 PF07676.12 ETO04528.1 - 0.15 12.1 9.6 19 5.4 0.0 6.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF1438 PF07270.11 ETO04528.1 - 0.17 12.0 1.0 4.9 7.2 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1438) ABC_tran PF00005.27 ETO04528.1 - 1.5 9.4 4.6 1.8 9.1 0.0 3.4 3 0 0 3 3 3 0 ABC transporter WD40 PF00400.32 ETO04529.1 - 2e-09 37.9 3.9 1.6e-05 25.5 0.0 2.8 2 1 0 2 2 2 2 WD domain, G-beta repeat YrbL-PhoP_reg PF10707.9 ETO04529.1 - 0.069 12.7 1.3 0.098 12.2 1.3 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL DUF16 PF01519.16 ETO04531.1 - 0.0032 17.9 7.1 0.0047 17.4 7.0 1.3 1 1 0 1 1 1 1 Protein of unknown function DUF16 XLF PF09302.11 ETO04531.1 - 0.16 12.1 5.0 0.21 11.8 5.0 1.1 1 0 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF641 PF04859.12 ETO04531.1 - 0.35 11.2 4.7 0.43 10.9 4.5 1.4 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Bap31_Bap29_C PF18035.1 ETO04531.1 - 0.55 10.3 6.9 0.29 11.2 2.7 2.3 2 1 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain zf-C2HE PF16278.5 ETO04531.1 - 5.3 7.6 12.1 4.5 7.8 8.9 2.5 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger TTL PF03133.15 ETO04533.1 - 9.5e-05 21.7 0.0 0.00013 21.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ETO04533.1 - 0.033 13.4 0.0 0.041 13.1 0.0 1.2 1 0 0 1 1 1 0 YheC/D like ATP-grasp Phage_pRha PF09669.10 ETO04534.1 - 0.098 13.2 3.1 0.73 10.4 0.1 2.6 3 0 0 3 3 3 0 Phage regulatory protein Rha (Phage_pRha) DM4_12 PF07841.13 ETO04535.1 - 0.12 13.1 0.1 0.15 12.7 0.1 1.3 1 0 0 1 1 1 0 DM4/DM12 family DUF4636 PF15468.6 ETO04539.1 - 0.012 15.3 4.1 0.014 15.2 3.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4636) DUF1828 PF08861.10 ETO04539.1 - 0.036 14.4 1.1 0.062 13.6 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF1828 MAP17 PF15807.5 ETO04539.1 - 0.54 10.5 4.0 0.75 10.0 4.0 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 ZZ PF00569.17 ETO04540.1 - 0.0049 16.7 0.8 0.011 15.6 0.8 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type PI_PP_C PF18365.1 ETO04540.1 - 0.018 15.0 1.6 0.28 11.2 0.0 3.1 3 1 1 4 4 4 0 Phosphoinositide phosphatase C-terminal domain VPS9 PF02204.18 ETO04540.1 - 0.052 13.8 0.9 0.34 11.2 0.3 2.5 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain DUF3783 PF12646.7 ETO04540.1 - 0.083 12.9 0.6 1.7 8.7 0.0 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3783) DUF4279 PF14106.6 ETO04540.1 - 0.096 12.9 1.7 2.6 8.3 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4279) DUF3713 PF12506.8 ETO04540.1 - 0.17 12.2 5.4 0.11 12.9 2.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3713) COMPASS-Shg1 PF05205.12 ETO04540.1 - 0.27 12.0 9.2 0.098 13.4 0.9 3.2 2 1 1 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 DNA_pol_A_exo1 PF01612.20 ETO04541.1 - 0.00011 21.9 0.8 0.00025 20.8 0.1 2.0 3 0 0 3 3 3 1 3'-5' exonuclease PMC2NT PF08066.12 ETO04541.1 - 0.0011 19.7 1.1 0.0031 18.2 0.2 2.2 3 0 0 3 3 3 1 PMC2NT (NUC016) domain Kelch_6 PF13964.6 ETO04542.1 - 0.00011 22.4 1.4 0.51 10.7 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO04542.1 - 0.00032 20.7 0.7 0.14 12.1 0.0 3.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO04542.1 - 0.19 11.4 2.0 3.8 7.2 0.0 3.4 4 0 0 4 4 4 0 Kelch motif F-box-like PF12937.7 ETO04543.1 - 0.0033 17.3 0.0 0.0082 16.0 0.0 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO04543.1 - 0.0081 16.0 0.0 0.023 14.6 0.0 1.8 1 0 0 1 1 1 1 F-box domain CENP-B_dimeris PF09026.10 ETO04543.1 - 0.35 11.3 5.1 0.76 10.2 5.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cnd2 PF05786.14 ETO04543.1 - 0.62 8.7 4.8 0.89 8.1 4.8 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 CTP_transf_like PF01467.26 ETO04544.1 - 6e-07 29.7 0.0 1.7e-06 28.3 0.0 1.7 1 1 0 1 1 1 1 Cytidylyltransferase-like IlvC PF01450.19 ETO04544.1 - 0.094 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, catalytic domain DUF3944 PF13099.6 ETO04545.1 - 0.18 11.7 1.1 0.34 10.8 1.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) REC104 PF17378.2 ETO04545.1 - 0.26 11.1 2.9 7.3 6.4 0.0 2.4 3 0 0 3 3 3 0 Meiotic recombination protein REC104 Metal_resist PF13801.6 ETO04546.1 - 0.64 10.2 2.8 1.2 9.4 2.8 1.5 1 0 0 1 1 1 0 Heavy-metal resistance SelP_N PF04592.14 ETO04546.1 - 6.3 6.1 11.7 18 4.6 11.7 1.8 1 0 0 1 1 1 0 Selenoprotein P, N terminal region HSP90 PF00183.18 ETO04547.1 - 1.6e-223 743.3 28.9 1.6e-223 743.3 28.9 2.1 2 0 0 2 2 2 1 Hsp90 protein HATPase_c PF02518.26 ETO04547.1 - 2.8e-14 53.6 0.0 6.1e-14 52.5 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO04547.1 - 1.5e-09 37.8 0.0 6e-09 35.9 0.0 2.0 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase IER PF05760.12 ETO04547.1 - 3.1 8.0 7.4 5.4 7.2 0.9 2.7 3 0 0 3 3 3 0 Immediate early response protein (IER) Not3 PF04065.15 ETO04548.1 - 4.5e-46 157.1 36.0 4.5e-46 157.1 36.0 4.5 4 2 2 6 6 6 2 Not1 N-terminal domain, CCR4-Not complex component DHC_N2 PF08393.13 ETO04550.1 - 1.4e-13 50.8 0.2 1.6e-13 50.6 0.2 1.1 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 Macoilin PF09726.9 ETO04552.1 - 0.019 13.6 24.4 0.02 13.4 24.4 1.1 1 0 0 1 1 1 0 Macoilin family LAP1C PF05609.12 ETO04552.1 - 2.5 7.1 25.7 3.3 6.7 25.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nop14 PF04147.12 ETO04552.1 - 4 5.5 43.5 5.8 5.0 43.5 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4551 PF15087.6 ETO04552.1 - 7.4 5.3 18.8 10 4.8 18.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Melibiase_2 PF16499.5 ETO04553.1 - 4e-11 42.6 3.0 3.7e-05 23.1 0.1 3.3 1 1 2 3 3 3 3 Alpha galactosidase A Solute_trans_a PF03619.16 ETO04554.1 - 1e-35 123.6 6.4 1.2e-35 123.3 6.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PIRT PF15099.6 ETO04554.1 - 0.071 12.7 0.2 0.12 12.0 0.2 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family Solute_trans_a PF03619.16 ETO04555.1 - 3.6e-30 105.4 3.1 4.6e-30 105.0 3.1 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Colicin_V PF02674.16 ETO04555.1 - 0.024 14.6 0.5 0.037 14.0 0.5 1.2 1 0 0 1 1 1 0 Colicin V production protein DUF4293 PF14126.6 ETO04555.1 - 0.055 13.7 1.5 0.084 13.1 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) Tmemb_cc2 PF10267.9 ETO04558.1 - 0.018 14.2 1.1 0.019 14.1 1.1 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein DUF4207 PF13904.6 ETO04558.1 - 0.11 12.1 0.8 0.14 11.8 0.5 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4207) Ribosomal_L18_c PF14204.6 ETO04559.1 - 3.3e-26 92.0 3.1 3.7e-26 91.9 3.1 1.1 1 0 0 1 1 1 1 Ribosomal L18 C-terminal region DUF1476 PF07345.11 ETO04559.1 - 0.016 15.6 0.0 0.023 15.1 0.0 1.3 1 1 0 1 1 1 0 ATPase inhibitor subunit zeta DUF4446 PF14584.6 ETO04559.1 - 0.42 10.6 1.6 0.55 10.2 1.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Ribosomal_L18_c PF14204.6 ETO04560.1 - 4.2e-15 56.5 9.4 1.2e-14 55.0 9.4 1.7 1 1 0 1 1 1 1 Ribosomal L18 C-terminal region Lsr2 PF11774.8 ETO04560.1 - 0.073 13.2 0.7 0.095 12.8 0.7 1.3 1 0 0 1 1 1 0 Lsr2 Ion_trans PF00520.31 ETO04561.1 - 1.5e-20 73.4 16.1 2.2e-20 72.9 16.1 1.2 1 0 0 1 1 1 1 Ion transport protein DUF2703 PF10865.8 ETO04561.1 - 0.17 12.1 0.5 0.36 11.0 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2703) KIP1 PF07765.12 ETO04561.1 - 1.9 8.7 7.0 8.4 6.6 1.2 2.5 2 0 0 2 2 2 0 KIP1-like protein DUF1664 PF07889.12 ETO04561.1 - 2.2 8.3 5.0 1.4 9.0 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Ion_trans PF00520.31 ETO04562.1 - 9e-11 41.5 24.0 1.7e-09 37.3 14.3 2.3 2 0 0 2 2 2 2 Ion transport protein EF-hand_7 PF13499.6 ETO04562.1 - 1e-07 32.3 2.2 5.5e-05 23.5 0.8 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO04562.1 - 7.7e-07 28.2 0.1 0.00011 21.5 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO04562.1 - 2e-06 27.3 0.2 0.0012 18.6 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO04562.1 - 2.4e-05 23.6 0.1 0.00015 21.1 0.0 2.2 2 0 0 2 2 2 1 EF hand PKD_channel PF08016.12 ETO04562.1 - 0.0011 17.8 9.2 0.0029 16.3 9.2 1.7 1 0 0 1 1 1 1 Polycystin cation channel EF-hand_8 PF13833.6 ETO04562.1 - 0.11 12.4 1.1 0.55 10.1 0.3 2.2 1 1 1 2 2 2 0 EF-hand domain pair GutM PF06923.11 ETO04562.1 - 0.17 12.0 0.4 0.48 10.5 0.4 1.7 1 0 0 1 1 1 0 Glucitol operon activator protein (GutM) zf-LITAF-like PF10601.9 ETO04562.1 - 0.23 11.7 0.0 0.23 11.7 0.0 4.2 4 1 1 5 5 5 0 LITAF-like zinc ribbon domain HemY_N PF07219.13 ETO04562.1 - 6.8 6.9 9.8 9.6 6.5 0.1 3.4 4 0 0 4 4 4 0 HemY protein N-terminus GST_C_3 PF14497.6 ETO04563.1 - 3e-15 56.2 0.0 5.3e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO04563.1 - 4.6e-08 33.2 0.1 1.1e-07 32.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETO04563.1 - 0.01 15.8 0.0 0.022 14.8 0.0 1.5 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Cas_DxTHG PF09455.10 ETO04564.1 - 0.055 13.0 10.3 0.055 13.0 10.3 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family IMD PF08397.11 ETO04564.1 - 0.52 9.6 21.8 0.81 9.0 21.8 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF4569 PF15133.6 ETO04564.1 - 1.3 8.7 8.4 1.5 8.5 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Membralin PF09746.9 ETO04564.1 - 2.7 7.0 5.0 2.6 7.0 5.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein PIEZO PF15917.5 ETO04564.1 - 3 7.3 15.7 3.3 7.1 15.7 1.3 1 0 0 1 1 1 0 Piezo RIO1 PF01163.22 ETO04564.1 - 3.5 7.2 16.5 2.8 7.5 15.4 1.4 1 1 0 1 1 1 0 RIO1 family ALMT PF11744.8 ETO04564.1 - 4 6.1 10.7 5.2 5.8 10.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter ubiquitin PF00240.23 ETO04565.1 - 1.8e-83 274.3 19.3 2.6e-27 94.4 0.2 5.1 3 1 2 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 ETO04565.1 - 6.4e-35 118.8 14.1 2.8e-13 49.5 0.3 4.1 3 1 1 4 4 4 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO04565.1 - 7.3e-15 55.2 9.6 0.00014 22.2 0.2 5.1 3 2 1 4 4 4 4 Ubiquitin-like domain DUF2407 PF10302.9 ETO04565.1 - 4e-09 37.0 2.0 0.13 12.9 0.0 3.3 2 1 1 3 3 3 3 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ETO04565.1 - 5.2e-09 35.9 5.3 0.0057 16.6 0.1 3.4 3 0 0 3 3 3 3 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO04565.1 - 1.2e-08 35.0 0.3 0.043 13.9 0.0 4.3 3 3 0 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO04565.1 - 1.5e-08 34.8 8.8 0.059 13.7 0.4 3.4 3 1 0 3 3 3 3 Ubiquitin-like domain PI3K_rbd PF00794.18 ETO04565.1 - 0.00094 19.3 4.8 4.7 7.4 0.1 3.7 3 1 0 3 3 3 2 PI3-kinase family, ras-binding domain UN_NPL4 PF11543.8 ETO04565.1 - 0.031 14.8 0.5 19 5.8 0.0 3.2 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 COMMD1_N PF17221.3 ETO04565.1 - 0.082 13.2 0.6 6.7 7.1 0.0 2.8 3 1 0 3 3 3 0 COMMD1 N-terminal domain PI3K_p85B PF02192.16 ETO04565.1 - 0.11 12.3 1.8 52 3.7 0.1 3.6 3 0 0 3 3 3 0 PI3-kinase family, p85-binding domain Ank_3 PF13606.6 ETO04566.1 - 4.3e-07 29.7 0.6 0.00018 21.7 0.2 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO04566.1 - 1.2e-05 25.7 0.0 4.6e-05 23.9 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO04566.1 - 2e-05 24.7 0.1 5.5e-05 23.4 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO04566.1 - 0.00011 22.5 0.7 0.00031 21.1 0.2 2.1 2 0 0 2 2 2 1 Ankyrin repeat Med5 PF08689.10 ETO04566.1 - 0.0029 15.5 1.9 0.011 13.6 0.2 2.0 2 0 0 2 2 2 1 Mediator complex subunit Med5 Ank_4 PF13637.6 ETO04566.1 - 0.0031 18.0 0.4 0.055 14.1 0.5 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) HU-DNA_bdg PF14848.6 ETO04566.1 - 0.11 12.5 0.4 0.33 11.0 0.4 1.7 1 0 0 1 1 1 0 DNA-binding domain RGS PF00615.19 ETO04568.1 - 4.4e-06 27.0 1.5 2.6e-05 24.5 1.5 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 ETO04569.1 - 1.2e-11 45.0 7.1 0.00015 22.5 0.2 4.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04569.1 - 1.4e-08 34.9 0.1 0.011 16.0 0.0 3.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO04569.1 - 1.4e-07 31.3 1.8 0.045 13.7 0.1 4.4 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO04569.1 - 2e-05 24.5 1.2 7.9e-05 22.6 0.1 2.4 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO04569.1 - 0.00073 19.0 0.4 4.5 6.5 0.0 3.1 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Kelch_5 PF13854.6 ETO04569.1 - 0.012 15.6 1.5 0.02 14.8 0.4 2.1 2 0 0 2 2 2 0 Kelch motif Proteasome_A_N PF10584.9 ETO04569.1 - 0.025 14.3 1.2 46 3.8 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETO04569.1 - 0.17 11.5 0.0 0.3 10.6 0.0 1.4 1 1 0 1 1 1 0 PQQ-like domain ABC_export PF16962.5 ETO04569.1 - 0.17 10.3 0.7 0.22 9.9 0.7 1.1 1 0 0 1 1 1 0 Putative ABC exporter WD40 PF00400.32 ETO04570.1 - 9.9e-27 92.7 38.6 1e-05 26.2 1.5 9.6 7 5 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04570.1 - 2.3e-16 59.8 2.0 0.028 14.7 0.0 6.5 6 1 0 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04570.1 - 1e-08 34.4 7.5 0.0022 16.8 0.1 4.7 2 2 1 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO04570.1 - 0.00096 19.8 1.1 0.00096 19.8 1.1 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO04570.1 - 0.016 15.6 1.2 0.048 14.1 0.2 2.3 2 0 0 2 2 2 0 TRAF-like zinc-finger Actin PF00022.19 ETO04571.1 - 6e-87 291.9 0.0 2.5e-86 289.8 0.0 1.7 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO04571.1 - 0.0066 15.3 0.1 0.011 14.6 0.1 1.3 1 1 0 1 1 1 1 MreB/Mbl protein Jas PF16135.5 ETO04573.1 - 0.088 13.0 0.1 0.25 11.6 0.1 1.7 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling WD40 PF00400.32 ETO04574.1 - 2.5e-57 189.5 20.2 4.3e-09 36.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO04574.1 - 2.8e-18 66.0 1.7 0.00099 18.2 0.2 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO04574.1 - 2.2e-16 59.9 2.8 0.0013 19.0 0.1 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04574.1 - 1.6e-08 34.2 2.3 0.00011 21.6 1.1 2.8 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO04574.1 - 9.1e-08 31.9 3.8 2.7 8.1 0.0 5.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO04574.1 - 1.8e-06 26.7 0.9 0.013 14.1 0.0 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain Frtz PF11768.8 ETO04574.1 - 5.3e-05 21.7 3.2 0.055 11.8 0.2 3.1 1 1 2 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 ETO04574.1 - 0.00014 20.6 9.6 1.5 7.4 0.1 5.5 1 1 5 6 6 6 3 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO04574.1 - 0.0015 17.3 0.4 0.038 12.8 0.1 3.2 2 1 0 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nucleoporin_N PF08801.11 ETO04574.1 - 0.0026 16.6 9.3 4 6.1 0.0 4.7 1 1 3 4 4 4 2 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO04574.1 - 0.95 9.2 0.0 0.95 9.2 0.0 4.8 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature RPEL PF02755.15 ETO04576.1 - 0.0011 18.5 1.0 1.2 8.9 0.0 2.7 2 0 0 2 2 2 2 RPEL repeat WD40 PF00400.32 ETO04577.1 - 3e-43 145.0 20.8 6.6e-10 39.4 0.1 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04577.1 - 3.5e-17 62.5 7.7 4e-07 30.3 0.0 7.1 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04577.1 - 7.1e-14 51.5 0.4 0.024 13.6 0.0 5.4 1 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO04577.1 - 0.00043 19.7 1.0 0.85 8.9 0.0 4.4 2 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO04577.1 - 0.0021 17.9 3.3 17 5.5 0.1 4.6 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat PUB PF09409.10 ETO04577.1 - 0.0057 16.6 0.5 0.07 13.1 0.4 2.8 2 0 0 2 2 2 1 PUB domain Proteasome_A_N PF10584.9 ETO04577.1 - 0.12 12.1 2.8 25 4.7 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature ATP-cone PF03477.16 ETO04578.1 - 0.051 14.2 0.1 0.091 13.3 0.1 1.3 1 0 0 1 1 1 0 ATP cone domain gag-asp_proteas PF13975.6 ETO04579.1 - 0.0073 16.8 0.0 0.016 15.8 0.0 1.5 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Ribosomal_L6e PF01159.19 ETO04579.1 - 0.14 12.7 3.1 0.92 10.1 0.1 2.5 2 0 0 2 2 2 0 Ribosomal protein L6e Ints3 PF10189.9 ETO04580.1 - 0.0006 19.2 0.5 0.00093 18.5 0.5 1.4 1 0 0 1 1 1 1 Integrator complex subunit 3 YlbD_coat PF14071.6 ETO04580.1 - 0.019 15.2 0.4 0.04 14.2 0.4 1.5 1 0 0 1 1 1 0 Putative coat protein Urb2 PF10441.9 ETO04583.1 - 0.036 14.0 0.0 0.039 13.9 0.0 1.0 1 0 0 1 1 1 0 Urb2/Npa2 family WD40 PF00400.32 ETO04585.1 - 1.9e-43 145.6 12.7 2.4e-10 40.8 0.1 7.1 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04585.1 - 2.7e-20 72.5 0.4 0.0013 18.9 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04585.1 - 2.4e-10 40.2 4.1 0.0017 17.7 0.4 3.1 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO04585.1 - 4.1e-09 35.6 1.2 0.0039 15.9 0.1 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO04585.1 - 1.7e-07 30.2 0.5 0.006 15.2 0.1 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ETO04585.1 - 2.2e-07 30.1 0.4 0.33 9.8 0.0 4.3 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 ETO04585.1 - 0.00028 20.0 0.2 0.041 12.9 0.0 2.9 3 1 1 4 4 4 1 VID27 C-terminal WD40-like domain PQQ_2 PF13360.6 ETO04585.1 - 0.00043 19.9 0.0 0.0084 15.7 0.0 2.4 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 ETO04585.1 - 0.00092 19.0 0.0 9.7 6.3 0.0 4.2 4 0 0 4 4 4 1 PQQ enzyme repeat PD40 PF07676.12 ETO04585.1 - 0.0013 18.6 3.3 13 5.8 0.0 5.1 5 1 1 6 6 6 0 WD40-like Beta Propeller Repeat Utp8 PF10395.9 ETO04585.1 - 0.0051 15.4 0.1 0.37 9.2 0.1 2.5 2 1 0 2 2 2 1 Utp8 family DUF2850 PF11012.8 ETO04585.1 - 0.0089 16.3 0.0 0.022 15.1 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2850) Nucleoporin_N PF08801.11 ETO04585.1 - 0.013 14.3 4.8 3.4 6.3 0.0 4.0 2 2 3 5 5 5 0 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO04585.1 - 0.055 12.5 0.4 0.27 10.2 0.1 2.1 1 1 0 2 2 2 0 Coatomer WD associated region Cdc6_C PF09079.11 ETO04586.1 - 0.17 11.9 0.2 0.27 11.2 0.2 1.3 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Actin PF00022.19 ETO04588.1 - 7.7e-07 28.1 0.0 7.7e-07 28.1 0.0 1.2 1 0 0 1 1 1 1 Actin DUF4209 PF13910.6 ETO04589.1 - 5.5e-28 97.0 3.0 3.4e-25 88.1 0.1 3.1 3 0 0 3 3 3 2 Domain of unknown function (DUF4209) GLTSCR1 PF15249.6 ETO04590.1 - 3.5 8.1 6.8 5.6 7.5 3.5 3.0 2 1 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein SLBP_RNA_bind PF15247.6 ETO04591.1 - 1.1e-15 57.4 5.6 1.1e-15 57.4 5.6 2.6 2 2 1 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain DUF4485 PF14846.6 ETO04591.1 - 0.76 9.9 4.7 0.82 9.8 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4485) DHHC PF01529.20 ETO04592.1 - 9.7e-35 119.6 10.7 9.7e-35 119.6 10.7 2.1 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF412 PF04217.13 ETO04592.1 - 0.012 15.5 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF412 Abhydrolase_9_N PF15420.6 ETO04592.1 - 0.11 12.5 0.0 0.17 11.9 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus Claudin_3 PF06653.11 ETO04592.1 - 0.7 9.8 7.4 1.3 9.0 0.1 2.1 1 1 1 2 2 2 0 Tight junction protein, Claudin-like 7TMR-DISM_7TM PF07695.11 ETO04592.1 - 0.72 9.7 10.0 1.8 8.4 7.1 2.6 2 1 0 2 2 2 0 7TM diverse intracellular signalling OKR_DC_1_N PF03709.15 ETO04593.1 - 0.0097 16.2 0.1 0.024 14.9 0.1 1.6 1 0 0 1 1 1 1 Orn/Lys/Arg decarboxylase, N-terminal domain TAN PF11640.8 ETO04594.1 - 0.045 13.9 0.6 2.6 8.1 0.2 2.3 2 1 0 2 2 2 0 Telomere-length maintenance and DNA damage repair GT-D PF08759.11 ETO04594.1 - 0.66 9.6 7.2 0.56 9.8 2.6 2.0 1 1 1 2 2 2 0 Glycosyltransferase GT-D fold WD40 PF00400.32 ETO04595.1 - 8.7e-45 149.8 12.1 4.4e-08 33.6 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04595.1 - 4.2e-18 65.4 3.7 0.032 14.5 0.2 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04595.1 - 4.1e-13 49.0 0.4 0.0021 17.1 0.0 5.4 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO04595.1 - 1.6e-08 34.7 0.7 0.0073 16.2 0.1 3.4 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO04595.1 - 1.1e-05 25.0 2.9 3.3e-05 23.4 1.0 2.1 1 1 0 2 2 2 1 WD40-like domain Cytochrom_D1 PF02239.16 ETO04595.1 - 0.00045 18.9 0.6 3.2 6.2 0.3 3.6 2 1 2 4 4 4 2 Cytochrome D1 heme domain Frtz PF11768.8 ETO04595.1 - 0.0021 16.5 0.1 0.62 8.3 0.0 2.9 1 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Nup160 PF11715.8 ETO04595.1 - 0.0061 15.3 0.7 7 5.2 0.0 4.1 4 1 1 5 5 5 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO04595.1 - 0.094 12.3 0.1 0.28 10.7 0.1 1.9 2 0 0 2 2 2 0 PQQ-like domain DUF5604 PF18300.1 ETO04595.1 - 0.1 12.6 0.9 0.76 9.8 0.1 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5604) Str_synth PF03088.16 ETO04595.1 - 0.12 12.5 0.1 6.3 7.0 0.0 3.0 2 2 1 3 3 3 0 Strictosidine synthase Utp8 PF10395.9 ETO04595.1 - 0.13 10.7 0.7 37 2.6 0.0 3.4 1 1 3 4 4 4 0 Utp8 family PD40 PF07676.12 ETO04595.1 - 0.16 11.9 1.9 11 6.1 0.1 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF4254 PF14063.6 ETO04596.1 - 0.0084 15.9 0.2 0.04 13.7 0.2 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF4254) NIF PF03031.18 ETO04597.1 - 2.2e-25 89.3 0.7 3.6e-25 88.6 0.7 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase FAM76 PF16046.5 ETO04597.1 - 0.016 14.6 8.8 0.019 14.3 8.8 1.1 1 0 0 1 1 1 0 FAM76 protein Eapp_C PF10238.9 ETO04597.1 - 0.026 14.6 5.8 0.042 13.9 5.8 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein T2SSL PF05134.13 ETO04597.1 - 0.088 12.1 1.6 0.12 11.7 1.6 1.3 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein L DDHD PF02862.17 ETO04597.1 - 0.13 12.4 2.3 0.14 12.3 2.3 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO04597.1 - 0.18 10.5 5.7 0.3 9.8 5.7 1.4 1 0 0 1 1 1 0 Presenilin SOBP PF15279.6 ETO04597.1 - 0.2 12.2 4.2 0.22 12.1 4.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4355 PF14265.6 ETO04597.1 - 0.21 11.8 15.2 0.33 11.2 15.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) AAA_31 PF13614.6 ETO04597.1 - 0.21 11.5 2.6 2.6 7.9 2.0 2.3 1 1 1 2 2 2 0 AAA domain NARP1 PF12569.8 ETO04597.1 - 0.24 10.3 12.7 0.27 10.1 12.7 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4637 PF15470.6 ETO04597.1 - 0.66 9.7 6.7 1 9.1 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Connexin PF00029.19 ETO04597.1 - 0.76 9.5 7.5 0.93 9.2 7.5 1.2 1 0 0 1 1 1 0 Connexin OATP PF03137.20 ETO04597.1 - 1.8 6.8 4.4 2.4 6.3 4.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2828 PF11443.8 ETO04597.1 - 4.4 5.3 10.9 5.7 4.9 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) VIT1 PF01988.19 ETO04597.1 - 6.1 6.6 6.5 7.8 6.3 6.5 1.1 1 0 0 1 1 1 0 VIT family ANAPC1 PF12859.7 ETO04597.1 - 7.1 7.2 0.0 7.1 7.2 0.0 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 1 Mit_KHE1 PF10173.9 ETO04598.1 - 0.031 14.4 0.8 0.042 13.9 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related NPFF PF15085.6 ETO04598.1 - 0.064 13.6 2.5 6.6 7.1 0.1 2.4 2 0 0 2 2 2 0 Neuropeptide FF MCM3AP_GANP PF16769.5 ETO04598.1 - 0.074 11.3 4.7 0.077 11.2 4.7 1.0 1 0 0 1 1 1 0 MCM3AP domain of GANP SNAPc19 PF15497.6 ETO04598.1 - 0.27 11.7 10.9 1.8 9.1 10.9 2.4 1 1 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 STAT_int PF02865.17 ETO04598.1 - 0.58 10.6 4.3 0.36 11.3 0.8 2.1 1 1 1 2 2 2 0 STAT protein, protein interaction domain Kelch_1 PF01344.25 ETO04600.1 - 0.0023 17.5 0.3 0.097 12.3 0.1 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO04600.1 - 0.017 15.2 0.0 0.24 11.5 0.0 2.5 2 0 0 2 2 2 0 Galactose oxidase, central domain TPR_12 PF13424.6 ETO04601.1 - 1.6e-81 268.6 17.6 1.4e-15 57.3 0.4 6.2 1 1 7 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04601.1 - 1.2e-47 158.6 0.0 9.1e-08 31.7 0.0 9.1 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04601.1 - 7.8e-37 123.6 48.6 2.5e-06 27.0 0.8 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04601.1 - 2.5e-35 117.7 32.8 3.2e-06 26.8 1.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04601.1 - 1e-34 116.0 7.0 3.1e-06 26.8 0.0 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04601.1 - 2.5e-34 114.6 43.0 1.6e-05 24.8 0.7 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO04601.1 - 6.3e-14 51.5 0.0 1.5 9.8 0.0 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO04601.1 - 2.2e-12 47.0 0.0 0.00059 19.3 0.0 3.1 1 1 2 3 3 3 3 MalT-like TPR region TPR_6 PF13174.6 ETO04601.1 - 2.9e-11 43.3 11.7 0.24 12.1 0.0 8.6 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO04601.1 - 1.7e-08 35.0 0.0 0.049 14.3 0.2 5.7 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO04601.1 - 8.9e-08 31.7 31.7 0.0097 15.6 0.4 8.2 8 0 0 8 8 8 3 TPR repeat TPR_17 PF13431.6 ETO04601.1 - 9.4e-06 25.7 13.1 13 6.4 0.0 9.0 11 0 0 11 11 9 0 Tetratricopeptide repeat TPR_21 PF09976.9 ETO04601.1 - 2.2e-05 24.3 2.6 0.85 9.3 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat-like domain SHNi-TPR PF10516.9 ETO04601.1 - 0.00014 21.2 1.8 2.2 7.8 0.1 5.4 6 0 0 6 6 6 1 SHNi-TPR TPR_19 PF14559.6 ETO04601.1 - 0.00083 19.8 2.4 17 6.0 0.0 5.5 5 3 1 6 6 6 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETO04601.1 - 0.0014 18.7 2.5 2.9 8.0 0.0 4.1 3 1 1 4 4 4 1 Domain of Unknown Function (DUF3856) DUF4810 PF16068.5 ETO04601.1 - 0.0055 17.2 9.2 0.8 10.3 0.2 5.5 7 0 0 7 7 4 1 Domain of unknown function (DUF4810) RE_MamI PF09567.10 ETO04601.1 - 0.029 14.0 4.2 0.031 13.9 0.3 2.6 3 0 0 3 3 3 0 MamI restriction endonuclease DUF5113 PF17140.4 ETO04601.1 - 0.038 13.8 13.9 6.4 6.6 0.1 6.4 4 1 3 7 7 7 0 Domain of unknown function (DUF5113) MIT PF04212.18 ETO04601.1 - 0.071 13.2 18.4 29 4.8 0.1 7.3 7 1 1 8 8 8 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO04601.1 - 0.14 12.4 19.9 2.9 8.2 0.1 5.5 4 2 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ETO04601.1 - 0.37 11.1 9.6 27 5.3 0.1 5.9 6 0 0 6 6 5 0 PPR repeat SPO22 PF08631.10 ETO04601.1 - 1.4 8.3 11.3 0.74 9.2 0.4 3.7 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like Pkinase PF00069.25 ETO04605.1 - 6.3e-62 209.3 0.2 8.6e-62 208.9 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04605.1 - 2.1e-25 89.5 2.1 7.5e-13 48.4 1.5 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase HAD_SAK_2 PF18143.1 ETO04606.1 - 2.3e-10 40.9 0.0 6e-10 39.6 0.0 1.7 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins Arm PF00514.23 ETO04607.1 - 0.087 12.9 0.2 71 3.7 0.1 4.4 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat Sigma70_ner PF04546.13 ETO04607.1 - 0.33 10.8 4.6 3.2 7.6 0.4 2.7 2 1 0 2 2 2 0 Sigma-70, non-essential region WAPL PF07814.13 ETO04608.1 - 0.004 16.0 0.1 0.0054 15.6 0.1 1.1 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin RTP1_C1 PF10363.9 ETO04608.1 - 0.004 17.3 0.2 0.0081 16.3 0.2 1.6 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 IBN_N PF03810.19 ETO04608.1 - 0.051 13.5 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Importin-beta N-terminal domain HEAT PF02985.22 ETO04608.1 - 0.091 13.1 0.2 0.94 9.9 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat UPF0147 PF03685.13 ETO04608.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) DUF3361 PF11841.8 ETO04608.1 - 0.2 11.6 0.7 0.42 10.5 0.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3361) Bul1_N PF04425.12 ETO04610.1 - 0.0014 17.5 3.2 0.0019 17.0 3.2 1.1 1 0 0 1 1 1 1 Bul1 N terminus EF-hand_6 PF13405.6 ETO04610.1 - 0.011 15.5 0.1 0.049 13.6 0.1 2.1 1 0 0 1 1 1 0 EF-hand domain UPF0193 PF05250.11 ETO04611.1 - 0.0015 18.4 15.5 0.0044 16.8 15.5 1.7 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0193) DUF2683 PF10884.8 ETO04611.1 - 0.013 15.8 1.2 0.036 14.3 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) GST_N PF02798.20 ETO04611.1 - 0.056 13.8 0.1 0.4 11.1 0.1 2.0 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain PAS_9 PF13426.7 ETO04611.1 - 0.49 10.7 3.8 2.1 8.6 3.2 2.4 1 1 1 2 2 2 0 PAS domain Noelin-1 PF12308.8 ETO04611.1 - 3.9 7.5 9.6 0.81 9.7 4.0 2.3 2 1 0 2 2 2 0 Neurogenesis glycoprotein XhlA PF10779.9 ETO04611.1 - 5.7 7.2 13.1 0.74 10.1 7.0 2.6 2 1 1 3 3 3 0 Haemolysin XhlA DUF2547 PF10818.8 ETO04611.1 - 7.9 7.5 7.8 12 6.9 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) Silic_transp PF03842.13 ETO04613.1 - 0.18 10.1 2.1 0.21 9.9 2.1 1.1 1 0 0 1 1 1 0 Silicon transporter Hid1 PF12722.7 ETO04613.1 - 0.42 8.7 10.3 0.48 8.5 10.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 ETO04613.1 - 1.9 8.5 4.2 2.4 8.2 4.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Serinc PF03348.15 ETO04616.1 - 0.02 13.8 0.1 0.021 13.8 0.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CARD PF00619.21 ETO04616.1 - 0.051 13.6 6.1 0.063 13.3 5.5 1.5 1 1 0 1 1 1 0 Caspase recruitment domain Peroxin-13_N PF04088.13 ETO04616.1 - 0.13 12.6 3.8 0.16 12.2 3.8 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FapA PF03961.13 ETO04616.1 - 0.55 8.8 14.5 0.65 8.5 14.5 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Biopterin_H PF00351.21 ETO04618.1 - 0.0073 15.4 1.4 0.16 11.0 1.4 2.0 1 1 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase DUF4116 PF13475.6 ETO04618.1 - 0.11 12.2 1.9 0.34 10.7 1.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4116) DUF2407 PF10302.9 ETO04620.1 - 0.15 12.6 0.4 0.15 12.6 0.4 4.4 2 2 0 2 2 2 0 DUF2407 ubiquitin-like domain Caldesmon PF02029.15 ETO04620.1 - 0.91 8.2 68.6 1.3 7.7 68.6 1.2 1 0 0 1 1 1 0 Caldesmon HSP70 PF00012.20 ETO04621.1 - 9.2e-36 123.2 3.1 6.5e-21 74.2 0.1 3.1 1 1 2 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 ETO04621.1 - 0.0048 15.8 0.0 0.0065 15.3 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein WD40 PF00400.32 ETO04622.1 - 4.1e-118 381.9 56.6 5e-08 33.5 0.2 16.2 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04622.1 - 4e-25 87.9 16.1 0.013 15.8 0.0 13.2 1 1 15 16 16 16 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04622.1 - 5.5e-20 71.6 4.3 0.72 8.8 0.0 13.0 1 1 9 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO04622.1 - 1.7e-16 60.5 15.5 7.3e-07 28.8 0.0 8.6 5 2 4 10 10 10 4 WD40-like domain Nup160 PF11715.8 ETO04622.1 - 5.9e-13 48.3 26.1 0.49 9.0 0.0 12.9 4 4 9 13 13 13 5 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO04622.1 - 3.6e-08 32.9 1.1 1.1e-07 31.4 1.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO04622.1 - 3.8e-07 29.9 21.6 1.3 9.1 0.2 9.1 10 0 0 10 10 10 3 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO04622.1 - 2e-06 27.9 17.1 1.1 9.4 0.2 9.8 4 3 7 11 11 11 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO04622.1 - 1.9e-05 23.4 9.0 0.029 12.9 0.1 5.5 3 1 1 6 6 6 1 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETO04622.1 - 5.1e-05 23.4 0.3 0.00013 22.0 0.3 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nucleoporin_N PF08801.11 ETO04622.1 - 0.00014 20.7 28.5 0.0096 14.7 0.2 8.9 3 3 7 10 10 10 1 Nup133 N terminal like Pentapeptide_3 PF13576.6 ETO04622.1 - 0.00044 20.3 0.7 0.0013 18.9 0.7 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO04622.1 - 0.0041 16.5 14.7 8 5.7 0.0 8.1 4 3 3 8 8 8 1 Neuroblastoma-amplified sequence, N terminal DUF3475 PF11961.8 ETO04622.1 - 0.11 12.5 0.9 72 3.6 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) DUF4988 PF16378.5 ETO04622.1 - 0.21 11.3 7.3 15 5.2 0.0 4.9 5 1 0 5 5 5 0 Domain of unknown function DUF3236 PF11576.8 ETO04623.1 - 0.11 12.2 1.3 0.14 11.9 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) RWD PF05773.22 ETO04626.1 - 4.7e-08 33.3 1.8 7.9e-08 32.6 0.4 1.9 2 0 0 2 2 2 1 RWD domain DUF1115 PF06544.12 ETO04626.1 - 0.0048 17.0 0.0 0.0088 16.1 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) DUF167 PF02594.16 ETO04627.1 - 3.1e-26 91.3 0.5 5.8e-26 90.4 0.5 1.5 1 0 0 1 1 1 1 Uncharacterised ACR, YggU family COG1872 Transketolase_N PF00456.21 ETO04627.1 - 0.098 11.6 0.7 0.12 11.3 0.7 1.1 1 0 0 1 1 1 0 Transketolase, thiamine diphosphate binding domain MTTB PF06253.11 ETO04627.1 - 0.12 10.3 0.2 0.17 9.9 0.2 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Pkinase PF00069.25 ETO04628.1 - 1.1e-22 80.7 1.0 1.2e-22 80.6 1.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04628.1 - 5.6e-18 65.2 0.2 5.8e-18 65.1 0.2 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 ETO04629.1 - 1.1e-05 26.0 0.1 0.00027 21.7 0.1 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Arm_3 PF16186.5 ETO04630.1 - 0.078 12.6 0.2 0.36 10.4 0.1 2.2 1 1 1 2 2 2 0 Atypical Arm repeat PRA1 PF03208.19 ETO04632.1 - 0.0049 16.5 0.8 0.0066 16.1 0.8 1.1 1 0 0 1 1 1 1 PRA1 family protein DivIC PF04977.15 ETO04633.1 - 0.0017 18.1 2.6 0.0017 18.1 2.6 3.8 4 1 0 4 4 4 1 Septum formation initiator MIP-T3_C PF17749.1 ETO04633.1 - 0.023 14.7 8.1 0.023 14.7 8.1 3.1 3 1 1 4 4 4 0 Microtubule-binding protein MIP-T3 C-terminal region zf-RING-like PF08746.11 ETO04633.1 - 0.084 13.2 2.1 1.4 9.3 2.1 2.5 1 1 0 1 1 1 0 RING-like domain DUF4199 PF13858.6 ETO04633.1 - 0.84 10.0 5.3 1.7 9.0 5.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) TSC22 PF01166.18 ETO04633.1 - 1.3 9.4 12.6 3.9 7.9 1.8 4.0 4 1 0 4 4 4 0 TSC-22/dip/bun family DUF948 PF06103.11 ETO04633.1 - 1.4 9.2 8.4 0.78 10.0 0.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TolA_bind_tri PF16331.5 ETO04633.1 - 3.7 7.7 14.9 9.6 6.4 2.3 2.6 2 0 0 2 2 2 0 TolA binding protein trimerisation Prefoldin PF02996.17 ETO04633.1 - 5.3 7.0 16.6 1.2 9.1 7.5 2.7 2 1 0 2 2 2 0 Prefoldin subunit SlyX PF04102.12 ETO04633.1 - 7.7 7.2 14.2 13 6.5 4.6 2.7 2 0 0 2 2 2 0 SlyX DUF1644 PF07800.12 ETO04634.1 - 0.069 13.2 14.7 1.2 9.1 12.8 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) DUF1664 PF07889.12 ETO04634.1 - 1.2 9.2 5.4 2.1 8.4 5.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Macoilin PF09726.9 ETO04634.1 - 1.3 7.5 18.0 1.6 7.2 18.0 1.1 1 0 0 1 1 1 0 Macoilin family OmpH PF03938.14 ETO04635.1 - 0.27 11.6 8.7 0.37 11.1 8.7 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SNAPc19 PF15497.6 ETO04637.1 - 0.08 13.4 5.3 0.084 13.3 5.3 1.1 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 ubiquitin PF00240.23 ETO04638.1 - 4.4e-18 64.8 0.1 6.8e-18 64.2 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO04638.1 - 2.4e-08 33.7 0.0 3.7e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETO04638.1 - 4.6e-07 29.8 0.0 0.0012 18.8 0.0 2.3 1 1 1 2 2 2 2 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ETO04638.1 - 4.6e-05 23.8 0.0 9.2e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain DUF1189 PF06691.11 ETO04638.1 - 0.008 15.8 3.4 0.016 14.8 3.1 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1189) SirB PF04247.12 ETO04638.1 - 1.2 9.3 10.3 4.6 7.4 10.3 1.9 1 1 0 1 1 1 0 Invasion gene expression up-regulator, SirB Methyltransf_28 PF02636.17 ETO04640.1 - 4.7e-31 108.4 0.0 6.2e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase WD40 PF00400.32 ETO04641.1 - 1.3e-65 215.8 7.3 3.8e-10 40.2 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04641.1 - 9.7e-22 77.1 0.2 0.0078 16.5 0.0 6.5 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04641.1 - 4.9e-14 52.0 0.1 0.12 11.4 0.0 6.5 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO04641.1 - 1.6e-12 47.4 0.1 3.6e-05 23.3 0.0 4.1 4 0 0 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO04641.1 - 1e-10 41.2 3.7 0.32 11.0 0.0 7.2 8 0 0 8 8 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO04641.1 - 1.1e-06 27.6 0.1 0.83 8.2 0.0 4.4 2 2 2 4 4 4 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO04641.1 - 0.00019 20.9 2.8 0.18 11.1 0.0 4.2 2 2 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO04641.1 - 0.00037 19.1 0.0 0.0096 14.5 0.0 2.6 2 1 1 3 3 3 1 Cytochrome D1 heme domain NHL PF01436.21 ETO04641.1 - 0.00067 19.6 0.1 0.044 13.8 0.0 3.4 4 0 0 4 4 4 1 NHL repeat PALB2_WD40 PF16756.5 ETO04641.1 - 0.002 17.1 0.0 2.3 7.1 0.0 2.9 3 0 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 ETO04641.1 - 0.0036 16.1 4.9 6.7 5.3 0.2 4.0 1 1 3 4 4 4 2 Nup133 N terminal like DUF5570 PF17731.1 ETO04641.1 - 0.014 15.4 0.0 27 4.9 0.0 3.5 2 1 2 4 4 4 0 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO04641.1 - 0.019 14.5 0.0 0.071 12.7 0.0 1.9 2 1 0 2 2 2 0 PQQ-like domain DUF4875 PF16175.5 ETO04641.1 - 0.078 13.1 0.0 4.2 7.5 0.0 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4875) Str_synth PF03088.16 ETO04641.1 - 0.13 12.4 0.0 6.5 7.0 0.0 3.4 3 2 1 4 4 4 0 Strictosidine synthase Kelch_1 PF01344.25 ETO04642.1 - 3e-06 26.7 2.9 1e-05 25.0 0.2 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO04642.1 - 0.00047 20.1 0.7 0.07 13.1 0.6 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO04642.1 - 0.0011 18.9 0.2 0.022 14.8 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO04642.1 - 0.011 16.0 5.2 0.69 10.3 0.6 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO04642.1 - 0.013 15.8 0.0 0.038 14.3 0.0 1.8 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO04642.1 - 0.073 13.1 1.1 0.93 9.6 0.3 3.1 4 0 0 4 4 4 0 Kelch motif BUD22 PF09073.10 ETO04642.1 - 1 8.6 52.5 1.5 8.1 52.5 1.1 1 0 0 1 1 1 0 BUD22 Peptidase_C14 PF00656.22 ETO04643.1 - 1.1e-11 45.2 2.8 3.1e-11 43.7 2.8 1.8 1 1 0 1 1 1 1 Caspase domain PUB PF09409.10 ETO04646.1 - 7.5e-05 22.6 0.9 0.00018 21.4 0.9 1.7 1 1 0 1 1 1 1 PUB domain WD40 PF00400.32 ETO04647.1 - 1.4e-12 47.9 1.1 3.1e-05 24.7 0.1 3.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04647.1 - 1.6e-06 28.3 0.0 0.14 12.5 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04647.1 - 0.0003 19.6 0.3 0.038 12.6 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO04647.1 - 0.036 13.0 0.5 1.7 7.5 0.1 2.1 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Rep_fac-A_C PF08646.10 ETO04648.1 - 0.082 12.6 0.1 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 Replication factor-A C terminal domain Kelch_1 PF01344.25 ETO04652.1 - 2.3e-05 23.9 1.3 0.0011 18.5 0.5 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO04652.1 - 0.00025 21.2 1.9 0.24 11.8 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO04652.1 - 0.00059 19.7 2.3 0.054 13.5 0.5 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO04652.1 - 0.004 17.4 0.4 0.047 14.0 0.0 2.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO04652.1 - 0.0071 16.3 1.8 0.11 12.6 0.8 2.9 3 0 0 3 3 3 1 Kelch motif LPD25 PF18840.1 ETO04652.1 - 0.025 15.1 2.1 0.025 15.1 2.1 2.5 3 0 0 3 3 3 0 Large polyvalent protein associated domain 25 Nbs1_C PF08599.10 ETO04652.1 - 0.099 12.8 2.2 0.16 12.1 0.4 2.2 2 0 0 2 2 2 0 DNA damage repair protein Nbs1 Fe-S_biosyn PF01521.20 ETO04654.1 - 2.5e-12 47.0 1.5 3.6e-12 46.5 1.5 1.2 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis FAIM1 PF06905.13 ETO04655.1 - 0.00021 21.1 3.0 0.00032 20.4 3.0 1.3 1 0 0 1 1 1 1 Fas apoptotic inhibitory molecule (FAIM1) CopC PF04234.12 ETO04655.1 - 0.091 13.8 1.3 0.1 13.6 0.1 1.7 2 0 0 2 2 2 0 CopC domain SSPI PF14098.6 ETO04656.1 - 0.017 15.3 0.1 0.039 14.1 0.1 1.6 1 0 0 1 1 1 0 Small, acid-soluble spore protein I Kelch_6 PF13964.6 ETO04658.1 - 0.011 16.0 0.2 0.34 11.3 0.0 2.3 2 0 0 2 2 2 0 Kelch motif DUF5418 PF17439.2 ETO04658.1 - 0.028 14.5 0.3 0.054 13.6 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5418) CNDH2_C PF16858.5 ETO04659.1 - 3.5 7.4 20.9 0.3 10.9 9.6 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Fer4 PF00037.27 ETO04660.1 - 6e-11 41.7 18.2 2e-06 27.4 3.2 3.2 3 0 0 3 3 3 3 4Fe-4S binding domain Fer4_7 PF12838.7 ETO04660.1 - 1.4e-10 41.6 7.8 5.2e-10 39.8 7.3 2.0 1 1 1 2 2 2 1 4Fe-4S dicluster domain Fer4_16 PF13484.6 ETO04660.1 - 4.2e-06 27.6 9.8 0.035 15.0 9.3 3.1 2 1 0 2 2 2 2 4Fe-4S double cluster binding domain Fer4_9 PF13187.6 ETO04660.1 - 5.9e-06 26.3 7.9 9.3e-06 25.7 6.6 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_10 PF13237.6 ETO04660.1 - 2.4e-05 24.4 7.0 6.2e-05 23.0 6.4 1.9 2 0 0 2 2 2 1 4Fe-4S dicluster domain Fer4_21 PF14697.6 ETO04660.1 - 7.1e-05 22.9 9.4 0.00019 21.5 0.6 2.7 3 0 0 3 3 3 2 4Fe-4S dicluster domain Fer4_6 PF12837.7 ETO04660.1 - 0.00046 20.1 19.0 0.00061 19.8 5.0 3.2 3 0 0 3 3 3 2 4Fe-4S binding domain Fer4_2 PF12797.7 ETO04660.1 - 0.00075 19.5 3.3 0.00075 19.5 3.3 2.6 3 0 0 3 3 2 1 4Fe-4S binding domain Fer4_8 PF13183.6 ETO04660.1 - 0.001 19.5 5.2 0.5 10.8 9.0 2.3 1 1 2 3 3 3 3 4Fe-4S dicluster domain c-SKI_SMAD_bind PF08782.10 ETO04660.1 - 0.0016 18.7 3.8 0.83 9.9 0.3 2.5 1 1 1 2 2 2 2 c-SKI Smad4 binding domain Fer4_4 PF12800.7 ETO04660.1 - 0.0025 18.2 1.7 0.0025 18.2 1.7 2.8 3 0 0 3 3 3 1 4Fe-4S binding domain Fer4_17 PF13534.6 ETO04660.1 - 0.0073 16.8 8.5 0.052 14.1 3.1 2.4 1 1 2 3 3 3 2 4Fe-4S dicluster domain ETF_QO PF05187.13 ETO04660.1 - 0.08 13.1 2.1 0.96 9.6 0.1 2.3 1 1 1 2 2 2 0 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S EPF PF17181.4 ETO04660.1 - 0.092 12.8 1.9 0.86 9.7 0.4 2.3 2 0 0 2 2 2 0 Epidermal patterning factor proteins Fer4_18 PF13746.6 ETO04660.1 - 0.7 10.1 5.5 11 6.2 5.4 2.2 1 1 0 1 1 1 0 4Fe-4S dicluster domain Fer4_13 PF13370.6 ETO04660.1 - 0.97 10.0 13.7 0.67 10.5 3.2 3.1 3 0 0 3 3 3 0 4Fe-4S single cluster domain of Ferredoxin I Fer4_22 PF17179.4 ETO04660.1 - 3.1 8.7 9.1 37 5.3 9.2 2.3 1 1 0 1 1 1 0 4Fe-4S dicluster domain CD20 PF04103.15 ETO04661.1 - 0.002 18.2 1.0 0.008 16.3 0.0 1.9 2 0 0 2 2 2 1 CD20-like family Cation_efflux PF01545.21 ETO04661.1 - 0.13 12.0 0.0 0.15 11.8 0.0 1.1 1 0 0 1 1 1 0 Cation efflux family AdoHcyase_NAD PF00670.21 ETO04662.1 - 2.8e-74 248.6 5.8 3.6e-74 248.2 5.8 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 ETO04662.1 - 5.9e-36 124.1 0.0 6.5e-36 124.0 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.19 ETO04662.1 - 4.9e-08 32.5 0.5 7.8e-08 31.9 0.5 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ETO04662.1 - 5.5e-06 26.1 0.2 8.5e-06 25.4 0.2 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain Shikimate_DH PF01488.20 ETO04662.1 - 2.2e-05 24.5 0.6 5.1e-05 23.4 0.6 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 ETO04662.1 - 0.00011 22.4 0.9 0.0013 19.0 0.8 2.4 1 1 0 1 1 1 1 TrkA-N domain THF_DHG_CYH_C PF02882.19 ETO04662.1 - 0.00011 21.5 3.5 0.00091 18.6 3.5 2.1 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain NAD_binding_7 PF13241.6 ETO04662.1 - 0.0011 19.4 0.3 0.002 18.5 0.3 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding 3HCDH_N PF02737.18 ETO04662.1 - 0.0083 16.0 1.4 0.051 13.4 0.3 2.0 1 1 1 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ELFV_dehydrog PF00208.21 ETO04662.1 - 0.022 14.5 0.1 0.033 13.9 0.1 1.4 1 0 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase XdhC_C PF13478.6 ETO04662.1 - 0.024 15.1 0.0 0.037 14.5 0.0 1.3 1 0 0 1 1 1 0 XdhC Rossmann domain Gp_dh_N PF00044.24 ETO04662.1 - 0.092 13.1 0.3 0.15 12.4 0.3 1.3 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain AAA_16 PF13191.6 ETO04663.1 - 1.8e-05 25.2 0.0 2.8e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ETO04663.1 - 5.4e-05 23.0 1.5 0.19 11.4 0.0 2.4 2 1 0 2 2 2 2 AAA domain ATPase_2 PF01637.18 ETO04663.1 - 0.00011 22.2 9.0 0.00098 19.1 9.0 2.1 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ETO04663.1 - 0.00014 22.1 0.4 0.0024 18.1 0.4 2.2 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 ETO04663.1 - 0.0034 17.5 4.5 0.059 13.4 0.0 2.2 1 1 1 2 2 2 1 Helicase HerA, central domain AAA_29 PF13555.6 ETO04663.1 - 0.0073 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain RNA_helicase PF00910.22 ETO04663.1 - 0.0096 16.3 3.8 0.17 12.3 1.4 3.3 2 1 0 2 2 2 1 RNA helicase RsgA_GTPase PF03193.16 ETO04663.1 - 0.026 14.4 0.1 0.15 12.0 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase eIF3_p135 PF12807.7 ETO04663.1 - 0.033 14.2 0.4 0.044 13.8 0.4 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 14-3-3 PF00244.20 ETO04663.1 - 0.046 13.2 4.7 0.078 12.5 4.4 1.5 1 1 0 1 1 1 0 14-3-3 protein IstB_IS21 PF01695.17 ETO04663.1 - 0.071 12.8 0.0 0.094 12.4 0.0 1.4 1 1 0 1 1 1 0 IstB-like ATP binding protein C4 PF01413.19 ETO04663.1 - 0.19 12.1 0.8 2.7 8.4 0.1 2.3 2 0 0 2 2 2 0 C-terminal tandem repeated domain in type 4 procollagen Roc PF08477.13 ETO04663.1 - 0.24 11.6 2.7 0.97 9.7 0.0 2.6 2 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase FRB_dom PF08771.11 ETO04663.1 - 0.32 11.4 4.8 3.5 8.1 1.8 2.5 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain Enkurin PF13864.6 ETO04663.1 - 0.48 10.9 5.5 0.48 10.9 3.2 2.1 2 1 0 2 2 2 0 Calmodulin-binding FMP23 PF17315.2 ETO04665.1 - 0.0058 16.8 0.6 0.012 15.8 0.6 1.5 1 0 0 1 1 1 1 Found in mitochondrial proteome DUF4256 PF14066.6 ETO04666.1 - 0.075 12.7 0.2 0.12 12.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4256) Zip PF02535.22 ETO04668.1 - 0.14 11.4 0.0 0.14 11.4 0.0 3.3 3 1 1 4 4 4 0 ZIP Zinc transporter Cytomega_UL84 PF06284.11 ETO04668.1 - 0.57 8.6 6.5 0.9 7.9 6.5 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein TFIIA PF03153.13 ETO04668.1 - 1.9 8.4 32.2 0.27 11.2 25.1 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF775 PF05603.12 ETO04668.1 - 2.4 7.6 8.3 0.55 9.7 4.0 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF775) SMC_N PF02463.19 ETO04669.1 - 3.9e-22 78.8 1.9 2e-21 76.5 0.0 3.1 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO04669.1 - 2.2e-17 64.3 1.2 2.2e-17 64.3 1.2 7.1 4 2 2 6 6 6 1 AAA domain AAA_29 PF13555.6 ETO04669.1 - 6.2e-09 35.5 0.0 1.2e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_15 PF13175.6 ETO04669.1 - 2.2e-07 30.9 0.0 2.2e-07 30.9 0.0 5.2 3 2 2 5 5 5 1 AAA ATPase domain AAA_21 PF13304.6 ETO04669.1 - 3.6e-06 27.0 0.0 0.0047 16.8 0.1 3.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system APG6_N PF17675.1 ETO04669.1 - 0.01 16.4 12.3 0.01 16.4 12.3 7.4 4 2 2 6 6 6 0 Apg6 coiled-coil region ABC_tran PF00005.27 ETO04669.1 - 0.1 13.1 0.0 0.1 13.1 0.0 5.9 4 2 0 4 4 4 0 ABC transporter AAA_25 PF13481.6 ETO04669.1 - 0.16 11.5 1.6 0.32 10.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain Peptidase_C54 PF03416.19 ETO04670.1 - 1.3e-79 267.5 0.2 1.7e-79 267.1 0.2 1.1 1 0 0 1 1 1 1 Peptidase family C54 Peptidase_C78 PF07910.13 ETO04670.1 - 0.029 13.8 0.3 0.23 10.9 0.2 2.2 2 0 0 2 2 2 0 Peptidase family C78 COPI_C PF06957.11 ETO04671.1 - 0.0031 16.3 4.0 0.0039 16.0 4.0 1.4 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus DUF3169 PF11368.8 ETO04671.1 - 0.014 14.9 2.1 0.026 14.0 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) CDC45 PF02724.14 ETO04671.1 - 0.1 10.9 8.7 0.14 10.4 8.7 1.2 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ETO04671.1 - 0.13 11.6 14.2 0.17 11.2 14.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MPM1 PF17234.2 ETO04671.1 - 0.24 11.7 4.5 0.38 11.0 4.5 1.3 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 RRN3 PF05327.11 ETO04671.1 - 0.78 8.2 7.5 1.1 7.8 7.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PTPRCAP PF15713.5 ETO04671.1 - 1 9.6 20.2 0.04 14.2 14.5 1.6 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Nop14 PF04147.12 ETO04671.1 - 1.4 7.0 17.6 1.8 6.7 17.6 1.2 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO04671.1 - 1.6 8.0 16.0 1.5 8.0 16.0 1.1 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO04671.1 - 1.7 7.4 2.8 2 7.1 2.8 1.1 1 0 0 1 1 1 0 Presenilin Merozoite_SPAM PF07133.11 ETO04671.1 - 2.6 8.0 34.8 1.4 8.9 30.2 2.0 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) SDA1 PF05285.12 ETO04671.1 - 3.5 7.0 20.3 0.23 10.8 15.8 1.3 2 0 0 2 2 2 0 SDA1 DUF4637 PF15470.6 ETO04671.1 - 7.5 6.2 17.7 17 5.1 17.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Suppressor_APC PF11414.8 ETO04672.1 - 0.00041 20.3 5.6 0.00094 19.2 0.8 2.8 1 1 2 3 3 3 1 Adenomatous polyposis coli tumour suppressor protein AAA_lid_9 PF17871.1 ETO04672.1 - 0.011 15.6 0.4 0.011 15.6 0.4 2.4 2 1 0 2 2 2 0 AAA lid domain Com_YlbF PF06133.11 ETO04672.1 - 0.014 15.9 20.8 0.037 14.6 5.9 2.1 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Syntaxin PF00804.25 ETO04672.1 - 0.041 13.6 12.0 0.072 12.8 3.8 2.1 2 0 0 2 2 2 0 Syntaxin Prefoldin_2 PF01920.20 ETO04672.1 - 0.042 13.8 2.6 0.042 13.8 2.6 3.1 2 1 1 3 3 3 0 Prefoldin subunit Nup54 PF13874.6 ETO04672.1 - 0.082 13.0 8.2 0.14 12.2 8.2 1.4 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF89 PF01937.19 ETO04672.1 - 0.095 11.6 6.2 0.13 11.2 6.2 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF89 DASH_Dad1 PF08649.10 ETO04672.1 - 0.096 12.9 0.9 0.23 11.7 0.1 2.1 2 0 0 2 2 2 0 DASH complex subunit Dad1 DUF4298 PF14131.6 ETO04672.1 - 0.12 12.4 9.6 1.4 8.9 2.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) DUF2443 PF10398.9 ETO04672.1 - 0.31 11.1 10.8 3.4 7.8 2.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2443) DASH_Dam1 PF08653.10 ETO04672.1 - 0.55 10.1 5.1 8.5 6.3 0.4 3.1 2 1 1 3 3 3 0 DASH complex subunit Dam1 Prefoldin PF02996.17 ETO04672.1 - 0.79 9.6 15.3 3.1 7.7 1.0 3.2 2 1 1 3 3 3 0 Prefoldin subunit PCRF PF03462.18 ETO04672.1 - 2.3 8.0 12.7 5.1 6.9 4.0 2.1 1 1 1 2 2 2 0 PCRF domain FliD_N PF02465.18 ETO04672.1 - 2.9 8.6 11.4 1.7 9.4 2.4 2.7 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus DUF4140 PF13600.6 ETO04672.1 - 9.4 6.7 7.1 18 5.9 0.8 2.7 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) P53_C PF11619.8 ETO04672.1 - 9.7 6.3 9.4 5.1 7.2 0.2 3.0 2 1 2 4 4 4 0 Transcription factor P53 - C terminal domain POPLD PF08170.12 ETO04674.1 - 0.0092 16.3 0.9 0.11 12.8 0.0 2.6 3 0 0 3 3 3 1 POPLD (NUC188) domain DUF2238 PF09997.9 ETO04674.1 - 0.04 13.7 0.1 0.075 12.8 0.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2238) POP1 PF06978.11 ETO04675.1 - 4.6e-12 46.4 13.8 8.6e-12 45.5 13.8 1.5 1 1 0 1 1 1 1 Ribonucleases P/MRP protein subunit POP1 Axin_b-cat_bind PF08833.10 ETO04676.1 - 0.2 11.8 0.1 0.48 10.6 0.0 1.7 1 1 0 1 1 1 0 Axin beta-catenin binding domain Ycf1 PF05758.12 ETO04680.1 - 6.3 4.5 9.9 8.8 4.0 9.9 1.1 1 0 0 1 1 1 0 Ycf1 TipE PF16972.5 ETO04680.1 - 7.7 5.6 14.6 11 5.1 14.6 1.3 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE SAM_2 PF07647.17 ETO04681.1 - 4.1e-05 23.6 0.1 0.00055 20.0 0.0 2.1 1 1 1 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO04681.1 - 0.0013 19.1 0.0 0.0027 18.1 0.0 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO04681.1 - 0.031 14.2 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DUF382 PF04037.13 ETO04682.1 - 0.012 15.8 0.5 5.1 7.3 0.0 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF382) DUF4407 PF14362.6 ETO04682.1 - 0.27 10.6 0.0 0.29 10.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_G_3 PF13385.6 ETO04684.1 - 5.4e-21 75.3 0.3 1e-20 74.4 0.3 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 ETO04684.1 - 0.089 12.5 0.1 0.39 10.4 0.1 1.9 1 1 0 1 1 1 0 Pentaxin family SDA1 PF05285.12 ETO04684.1 - 0.21 11.0 24.9 0.009 15.5 3.5 2.2 2 0 0 2 2 2 0 SDA1 THOC7 PF05615.13 ETO04685.1 - 0.1 12.9 1.2 0.26 11.6 1.2 1.9 1 1 0 1 1 1 0 Tho complex subunit 7 Phage_int_SAM_4 PF13495.6 ETO04685.1 - 0.25 11.8 2.7 1.7 9.2 0.1 2.9 2 1 1 3 3 3 0 Phage integrase, N-terminal SAM-like domain DUF587 PF04532.12 ETO04686.1 - 0.041 13.1 1.3 0.053 12.8 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF587) DUF4212 PF13937.6 ETO04688.1 - 0.024 15.0 0.0 0.1 13.0 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4212) DUF5533 PF17685.1 ETO04688.1 - 0.25 11.8 5.8 0.54 10.7 5.8 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5533) DUF4504 PF14953.6 ETO04690.1 - 0.0074 15.7 0.0 0.0092 15.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4504) DUF3671 PF12420.8 ETO04692.1 - 0.11 12.6 7.3 0.35 11.0 7.3 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF1430 PF07242.11 ETO04692.1 - 2.7 8.3 8.4 0.79 10.0 0.8 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1430) DEAD PF00270.29 ETO04693.1 - 4.3e-08 33.1 0.2 5.2e-08 32.9 0.2 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase SIT PF15330.6 ETO04694.1 - 1.2 9.6 4.6 0.89 10.0 0.2 2.5 2 1 1 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT MIT PF04212.18 ETO04695.1 - 2.9e-10 40.1 7.8 3.9e-08 33.2 4.6 2.1 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain Csm1_B PF18211.1 ETO04695.1 - 0.063 13.1 0.6 0.15 11.9 0.2 1.8 1 1 1 2 2 2 0 Csm1 subunit domain B MCU PF04678.13 ETO04695.1 - 0.065 13.3 2.4 0.074 13.1 2.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TPR_11 PF13414.6 ETO04695.1 - 0.077 12.7 1.3 0.22 11.3 1.3 1.7 1 0 0 1 1 1 0 TPR repeat TPR_1 PF00515.28 ETO04695.1 - 0.08 12.8 0.5 0.28 11.1 0.5 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat PRP9_N PF16958.5 ETO04695.1 - 0.087 12.8 9.2 0.1 12.6 9.2 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus LpoB PF13036.6 ETO04695.1 - 0.77 9.7 10.0 0.2 11.6 4.0 2.0 1 1 1 2 2 2 0 Peptidoglycan-synthase activator LpoB Alb1 PF09135.11 ETO04695.1 - 9.7 7.1 12.4 2.6e+02 2.6 12.4 2.0 1 1 0 1 1 1 0 Alb1 DUF2891 PF11199.8 ETO04696.1 - 0.016 14.2 0.1 0.023 13.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2891) Cofilin_ADF PF00241.20 ETO04697.1 - 9.4e-12 44.8 0.3 1.5e-11 44.1 0.3 1.3 1 1 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein eRF1_1 PF03463.15 ETO04699.1 - 0.0021 18.0 0.7 0.0037 17.2 0.7 1.4 1 0 0 1 1 1 1 eRF1 domain 1 TRM13 PF05206.14 ETO04699.1 - 0.0022 17.6 1.9 0.0022 17.6 1.9 1.7 1 1 0 2 2 2 1 Methyltransferase TRM13 DUF4290 PF14123.6 ETO04699.1 - 0.0042 16.7 0.2 0.01 15.4 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4290) Ribosomal_S15 PF00312.22 ETO04699.1 - 0.03 14.5 1.6 0.049 13.8 0.6 1.9 1 1 1 2 2 2 0 Ribosomal protein S15 WD40 PF00400.32 ETO04700.1 - 0.00024 21.8 0.3 0.00041 21.1 0.3 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat Csm1_N PF18504.1 ETO04700.1 - 0.0014 18.9 6.3 0.0014 18.9 6.3 1.8 1 1 0 1 1 1 1 Csm1 N-terminal domain DUF4164 PF13747.6 ETO04700.1 - 0.0065 16.7 1.3 0.0098 16.1 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4164) DUF771 PF05595.11 ETO04700.1 - 0.013 15.5 2.1 0.024 14.6 2.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF771) Cep57_CLD_2 PF14197.6 ETO04700.1 - 0.018 15.1 7.5 0.027 14.6 7.5 1.4 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Atg14 PF10186.9 ETO04700.1 - 0.11 11.6 7.2 0.12 11.5 7.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Golgin_A5 PF09787.9 ETO04700.1 - 0.13 11.7 9.4 0.14 11.6 9.4 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF812 PF05667.11 ETO04700.1 - 0.16 10.8 9.8 0.19 10.6 9.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Fmp27_WPPW PF10359.9 ETO04700.1 - 0.57 9.0 11.6 0.71 8.6 11.6 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4407 PF14362.6 ETO04700.1 - 0.6 9.4 4.8 0.7 9.2 4.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3069 PF11269.8 ETO04700.1 - 3.6 7.9 7.6 2.2 8.6 5.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3069) FapA PF03961.13 ETO04700.1 - 4.9 5.6 8.7 5.2 5.6 8.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A WD40 PF00400.32 ETO04701.1 - 0.001 19.9 0.5 0.037 14.9 0.1 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO04701.1 - 0.017 13.8 0.0 0.02 13.6 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 DUF755 PF05501.11 ETO04702.1 - 0.11 12.8 0.0 0.11 12.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF755) DUF5448 PF17526.2 ETO04703.1 - 0.095 12.9 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5448) WD40 PF00400.32 ETO04704.1 - 1.3e-36 124.0 31.9 1.5e-06 28.8 0.1 7.9 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04704.1 - 4.3e-10 39.8 7.6 0.015 15.6 0.0 6.0 6 1 0 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO04704.1 - 0.00042 20.9 2.1 0.00042 20.9 2.1 3.1 2 0 0 2 2 2 1 TRAF-type zinc finger DUF5028 PF16431.5 ETO04704.1 - 0.032 14.3 0.8 6.7 6.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5028) FlaC_arch PF05377.11 ETO04704.1 - 1.5 9.3 10.4 1 9.8 7.1 2.6 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DHR10 PF18595.1 ETO04704.1 - 4.9 7.2 31.9 0.08 13.0 7.6 3.5 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain zf-TRAF PF02176.18 ETO04705.1 - 5.9e-07 30.1 3.2 5.9e-07 30.1 3.2 2.5 1 1 1 2 2 2 1 TRAF-type zinc finger zf-RING_2 PF13639.6 ETO04705.1 - 0.098 13.0 0.3 0.098 13.0 0.3 2.5 3 1 0 3 3 3 0 Ring finger domain zf-TRAF_2 PF15965.5 ETO04705.1 - 4.5 7.8 11.1 0.091 13.2 3.4 2.1 1 1 1 2 2 2 0 TRAF-like zinc-finger NOA36 PF06524.12 ETO04707.1 - 1.9 7.8 14.3 1.9 7.8 14.3 1.0 1 0 0 1 1 1 0 NOA36 protein Cytomega_UL84 PF06284.11 ETO04707.1 - 2.7 6.4 6.5 2.8 6.3 6.5 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF2457 PF10446.9 ETO04707.1 - 7.3 5.6 21.8 8 5.5 21.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ETO04707.1 - 8.1 6.9 12.8 9.1 6.7 12.8 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Kelch_1 PF01344.25 ETO04709.1 - 0.00017 21.1 0.1 0.00037 20.0 0.1 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO04709.1 - 0.00076 19.4 0.1 0.0016 18.4 0.0 1.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO04709.1 - 0.0024 18.1 0.3 0.032 14.5 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO04709.1 - 0.025 14.9 0.1 0.2 12.0 0.1 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO04709.1 - 0.098 12.7 0.6 0.21 11.6 0.6 1.5 1 0 0 1 1 1 0 Kelch motif Gly-zipper_Omp PF13488.6 ETO04710.1 - 0.065 13.2 15.3 0.12 12.4 15.3 1.4 1 0 0 1 1 1 0 Glycine zipper HAUS6_N PF14661.6 ETO04710.1 - 0.58 9.7 7.3 0.15 11.6 3.8 1.7 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus Rick_17kDa_Anti PF05433.15 ETO04710.1 - 1.3 8.9 18.0 3.6 7.5 18.0 1.8 1 1 0 1 1 1 0 Glycine zipper 2TM domain DUF4770 PF15994.5 ETO04711.1 - 0.014 15.6 1.0 0.014 15.6 1.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4770) DUF4834 PF16118.5 ETO04711.1 - 0.015 16.3 16.0 0.06 14.3 2.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Zip PF02535.22 ETO04711.1 - 0.035 13.3 5.7 0.66 9.1 0.6 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Peptidase_S49_N PF08496.10 ETO04711.1 - 0.15 12.1 3.9 1.1 9.3 3.3 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FAM176 PF14851.6 ETO04711.1 - 0.4 10.3 10.9 5.9 6.5 0.1 2.3 2 0 0 2 2 2 0 FAM176 family FAM76 PF16046.5 ETO04711.1 - 0.44 9.9 12.4 0.14 11.5 2.8 2.1 2 0 0 2 2 2 0 FAM76 protein RXT2_N PF08595.11 ETO04711.1 - 0.64 10.0 17.0 2.8 8.0 4.0 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal Eapp_C PF10238.9 ETO04711.1 - 0.73 9.9 10.4 0.19 11.8 2.6 2.2 2 0 0 2 2 2 0 E2F-associated phosphoprotein ALMT PF11744.8 ETO04711.1 - 0.8 8.5 9.2 0.33 9.7 0.7 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter RP-C_C PF11800.8 ETO04711.1 - 0.91 9.6 8.1 2.3 8.3 2.1 2.3 2 0 0 2 2 2 0 Replication protein C C-terminal region Connexin PF00029.19 ETO04711.1 - 2 8.1 9.7 6.9 6.4 4.4 2.2 2 0 0 2 2 2 0 Connexin DUF913 PF06025.12 ETO04711.1 - 2.5 7.0 9.3 3 6.7 0.4 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CLN3 PF02487.17 ETO04711.1 - 2.6 7.0 9.2 3.3 6.7 0.4 2.1 2 0 0 2 2 2 0 CLN3 protein CPSF100_C PF13299.6 ETO04711.1 - 2.7 8.2 8.8 3.1 8.0 3.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Spt20 PF12090.8 ETO04711.1 - 3.2 7.3 28.8 5.7 6.5 18.1 2.2 2 0 0 2 2 2 0 Spt20 family Mak16 PF04874.14 ETO04711.1 - 5.3 7.7 14.4 2.4 8.8 4.1 2.4 2 0 0 2 2 2 0 Mak16 protein C-terminal region Serinc PF03348.15 ETO04711.1 - 5.4 5.8 7.3 4 6.3 0.5 2.1 2 0 0 2 2 2 0 Serine incorporator (Serinc) TraU PF06834.11 ETO04711.1 - 6.1 6.0 6.8 0.63 9.3 0.4 2.0 2 0 0 2 2 2 0 TraU protein DUF719 PF05334.13 ETO04711.1 - 7.5 6.7 12.4 7.1 6.8 6.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF719) HATPase_c PF02518.26 ETO04719.1 - 5.2e-08 33.4 0.1 7.7e-08 32.8 0.1 1.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO04719.1 - 1.1e-05 25.3 0.6 0.0005 19.9 0.1 2.4 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Ribosomal_L29 PF00831.23 ETO04719.1 - 0.19 11.7 2.0 1.9 8.5 0.1 2.6 3 0 0 3 3 3 0 Ribosomal L29 protein HSP90 PF00183.18 ETO04720.1 - 1e-71 242.4 19.1 3.9e-71 240.5 15.4 2.1 1 1 1 2 2 2 2 Hsp90 protein Pur_ac_phosph_N PF16656.5 ETO04721.1 - 2.4e-15 56.9 0.4 3.2e-15 56.5 0.4 1.2 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Metallophos PF00149.28 ETO04721.1 - 0.029 14.9 0.3 0.046 14.2 0.1 1.5 2 0 0 2 2 2 0 Calcineurin-like phosphoesterase EF-hand_1 PF00036.32 ETO04722.1 - 0.00043 19.6 0.0 0.069 12.7 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO04722.1 - 0.0017 18.1 0.1 1.9 8.6 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO04722.1 - 0.0069 16.8 0.1 0.15 12.5 0.1 2.3 1 1 0 1 1 1 1 EF-hand domain pair MFAP1 PF06991.11 ETO04724.1 - 1 9.1 38.4 1.2 8.9 38.4 1.0 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing GBP_C PF02841.14 ETO04724.1 - 3.6 6.9 40.4 3.9 6.8 40.4 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Hid1 PF12722.7 ETO04724.1 - 4.5 5.3 27.4 4.9 5.2 27.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Allexi_40kDa PF05549.11 ETO04724.1 - 8.9 5.7 13.0 11 5.4 13.0 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein CDC45 PF02724.14 ETO04724.1 - 9.4 4.4 28.3 9.4 4.4 28.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Band_7 PF01145.25 ETO04725.1 - 4.1e-16 59.5 3.0 4.1e-16 59.5 3.0 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 ETO04725.1 - 0.033 13.3 3.2 0.044 12.9 3.2 1.2 1 0 0 1 1 1 0 SigmaW regulon antibacterial Glyco_tran_WbsX PF14307.6 ETO04726.1 - 0.01 15.3 0.8 0.021 14.3 0.2 1.7 2 0 0 2 2 2 0 Glycosyltransferase WbsX IBR PF01485.21 ETO04727.1 - 2.9e-09 37.0 33.2 0.0019 18.4 0.7 3.7 4 0 0 4 4 4 3 IBR domain, a half RING-finger domain DUF2304 PF10066.9 ETO04727.1 - 0.19 11.9 8.5 1.2 9.4 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) CTP_transf_1 PF01148.20 ETO04727.1 - 0.3 10.8 7.8 0.13 12.0 4.2 1.8 2 0 0 2 2 2 0 Cytidylyltransferase family DUF2207 PF09972.9 ETO04727.1 - 1.5 7.5 5.8 3.5 6.3 5.1 1.8 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) zf-NADH-PPase PF09297.11 ETO04727.1 - 3.4 7.4 15.1 1.4 8.7 1.4 4.0 4 0 0 4 4 4 0 NADH pyrophosphatase zinc ribbon domain Pkinase PF00069.25 ETO04729.1 - 0.02 14.3 0.0 0.023 14.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase domain DUF2222 PF09984.9 ETO04730.1 - 0.068 13.1 4.7 0.16 11.8 4.4 1.8 1 1 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) HA2 PF04408.23 ETO04730.1 - 2.5 8.4 6.0 8.2 6.8 6.0 1.9 1 1 0 1 1 1 0 Helicase associated domain (HA2) Rsc14 PF08586.10 ETO04730.1 - 8.7 7.2 8.1 11 6.9 7.0 1.8 1 1 1 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Pkinase PF00069.25 ETO04731.1 - 2.8e-12 46.6 0.3 1.7e-11 44.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04731.1 - 0.0048 16.2 0.3 0.01 15.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pex14_N PF04695.13 ETO04731.1 - 7.3 7.2 12.2 3.5 8.3 8.5 1.9 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NOA36 PF06524.12 ETO04732.1 - 2.6 7.3 14.3 3.2 7.0 14.3 1.1 1 0 0 1 1 1 0 NOA36 protein BSP_II PF05432.11 ETO04732.1 - 2.8 7.5 17.6 3.6 7.2 17.6 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) zf-RING_2 PF13639.6 ETO04733.1 - 0.004 17.5 0.9 0.004 17.5 0.9 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_11 PF17123.5 ETO04733.1 - 0.0052 16.5 0.8 0.0052 16.5 0.8 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO04733.1 - 0.034 14.2 1.0 0.034 14.2 1.0 1.9 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO04733.1 - 1.1 9.2 3.3 0.5 10.3 0.7 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Kelch_4 PF13418.6 ETO04734.1 - 1.9e-21 75.8 9.9 4.6e-09 36.2 0.0 5.6 4 1 1 5 5 5 5 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO04734.1 - 6e-15 54.6 6.0 3e-09 36.3 0.0 4.9 4 0 0 4 4 4 4 Kelch motif Kelch_5 PF13854.6 ETO04734.1 - 1.5e-12 47.2 3.4 0.0012 18.8 0.0 4.9 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ETO04734.1 - 4.3e-12 45.9 6.2 2.1e-06 27.8 0.0 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ETO04734.1 - 1.1e-08 35.1 18.4 6.4e-05 23.1 0.1 6.5 6 1 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO04734.1 - 6.1e-08 32.3 8.4 1.6e-07 31.0 0.1 4.6 5 1 0 5 5 5 1 Kelch motif YajC PF02699.15 ETO04734.1 - 9.1 6.2 6.5 2 8.4 0.1 3.0 3 0 0 3 3 3 0 Preprotein translocase subunit WD40 PF00400.32 ETO04735.1 - 7.8e-25 86.7 4.4 3.2e-06 27.8 0.0 7.0 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04735.1 - 1.5e-19 70.1 1.0 0.00079 19.7 0.0 6.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04735.1 - 1.3e-07 30.9 2.1 0.47 9.4 0.0 5.0 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO04735.1 - 1e-05 25.3 2.6 0.13 12.2 0.0 4.8 6 0 0 6 6 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO04735.1 - 1.6e-05 23.7 0.4 0.033 12.8 0.1 2.7 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO04735.1 - 1.7e-05 24.3 1.4 0.36 10.1 0.0 3.9 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Utp8 PF10395.9 ETO04735.1 - 9.6e-05 21.1 4.2 0.073 11.6 0.2 3.8 1 1 2 4 4 4 2 Utp8 family SGL PF08450.12 ETO04735.1 - 0.00072 19.2 0.2 0.85 9.2 0.1 3.0 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region PALB2_WD40 PF16756.5 ETO04735.1 - 0.0097 14.9 1.5 0.065 12.1 0.1 2.8 3 2 0 4 4 4 1 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 ETO04735.1 - 0.0098 15.3 7.5 0.12 11.7 4.3 3.3 1 1 1 2 2 2 2 WD40-like domain DPPIV_N PF00930.21 ETO04735.1 - 0.0099 14.7 0.0 0.69 8.6 0.0 2.6 1 1 1 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PH_TFIIH PF08567.11 ETO04735.1 - 0.035 14.4 0.2 24 5.3 0.1 3.3 3 1 1 4 4 3 0 TFIIH p62 subunit, N-terminal domain DUF5570 PF17731.1 ETO04735.1 - 0.039 14.0 0.0 4.4 7.4 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO04735.1 - 0.15 11.7 3.1 9.6 6.0 0.0 3.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO04736.1 - 7e-08 32.5 5.6 0.063 13.6 0.1 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO04736.1 - 1.3e-06 27.8 0.3 0.25 11.0 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO04736.1 - 6.4e-05 22.9 5.6 0.0053 16.7 0.1 4.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO04736.1 - 0.00085 19.3 5.6 0.37 10.8 0.9 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO04736.1 - 0.0011 19.2 2.7 0.32 11.4 0.0 3.6 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO04736.1 - 0.066 13.2 2.3 9.8 6.3 0.1 4.6 5 0 0 5 5 5 0 Kelch motif AXH PF08517.12 ETO04737.1 - 3.4e-09 37.3 0.7 6.1e-09 36.4 0.0 1.7 2 0 0 2 2 2 1 Ataxin-1 and HBP1 module (AXH) Intein_splicing PF14890.6 ETO04737.1 - 1.3e-07 31.6 0.1 5e-07 29.7 0.1 2.1 1 1 0 1 1 1 1 Intein splicing domain PT-HINT PF07591.11 ETO04737.1 - 0.00026 21.3 0.1 0.0016 18.7 0.1 2.4 1 1 0 1 1 1 1 Pretoxin HINT domain eIF3_N PF09440.10 ETO04737.1 - 0.00059 20.3 0.4 0.00096 19.6 0.4 1.3 1 0 0 1 1 1 1 eIF3 subunit 6 N terminal domain Hint PF01079.20 ETO04737.1 - 0.0017 17.9 0.1 0.0099 15.4 0.1 2.0 1 1 0 1 1 1 1 Hint module Hint_2 PF13403.6 ETO04737.1 - 0.0017 18.6 0.0 0.12 12.7 0.1 2.7 3 0 0 3 3 3 1 Hint domain Hom_end_hint PF05203.16 ETO04737.1 - 0.0046 16.9 0.0 0.0046 16.9 0.0 1.9 3 0 0 3 3 3 1 Hom_end-associated Hint FbpA PF05833.11 ETO04737.1 - 0.022 13.5 1.8 0.03 13.1 1.8 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) TDP43_N PF18694.1 ETO04737.1 - 0.12 12.2 0.0 0.26 11.2 0.0 1.5 1 0 0 1 1 1 0 Transactive response DNA-binding protein N-terminal domain Mitoc_L55 PF09776.9 ETO04737.1 - 0.18 11.6 4.3 0.4 10.4 4.3 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L55 BBS1 PF14779.6 ETO04737.1 - 0.31 10.4 2.7 0.41 10.1 1.1 1.8 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 1 PET117 PF15786.5 ETO04737.1 - 0.8 10.0 4.5 1.8 8.9 4.5 1.6 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial Folate_carrier PF01770.18 ETO04738.1 - 0.11 11.3 0.2 0.18 10.5 0.2 1.3 1 0 0 1 1 1 0 Reduced folate carrier DUF2076 PF09849.9 ETO04738.1 - 1.4 8.9 10.2 6.8 6.7 6.7 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-CCHC PF00098.23 ETO04740.1 - 0.00025 20.9 1.7 0.00025 20.9 1.7 1.7 2 0 0 2 2 2 1 Zinc knuckle Flag1_repress PF03614.13 ETO04740.1 - 0.018 14.8 0.5 0.025 14.4 0.5 1.2 1 0 0 1 1 1 0 Repressor of phase-1 flagellin V-ATPase_H_C PF11698.8 ETO04740.1 - 0.043 13.9 0.5 0.23 11.6 0.5 2.0 1 1 1 2 2 2 0 V-ATPase subunit H UCH PF00443.29 ETO04741.1 - 4.2e-30 105.1 2.6 5.2e-19 68.7 0.3 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO04741.1 - 3.3e-09 36.8 12.3 1.2e-08 35.0 12.3 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CRA PF06589.11 ETO04741.1 - 2 8.5 6.2 0.87 9.7 0.4 2.8 3 0 0 3 3 3 0 Circumsporozoite-related antigen (CRA) ETRAMP PF09716.10 ETO04743.1 - 9 6.4 9.7 18 5.5 9.7 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) CAP_GLY PF01302.25 ETO04745.1 - 4.6e-26 90.6 1.3 1.8e-17 63.1 0.4 2.8 2 1 0 2 2 2 2 CAP-Gly domain PX PF00787.24 ETO04747.1 - 1.3e-15 57.4 0.8 1.3e-15 57.4 0.8 2.5 3 0 0 3 3 3 1 PX domain CAP_GLY PF01302.25 ETO04748.1 - 3.7e-37 126.2 5.5 7.9e-20 70.7 0.8 2.1 2 0 0 2 2 2 2 CAP-Gly domain IL33 PF15095.6 ETO04748.1 - 0.0034 16.9 0.6 0.25 10.8 0.1 2.1 2 0 0 2 2 2 2 Interleukin 33 ID PF18543.1 ETO04748.1 - 0.064 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Intracellular delivery domain Ribosomal_L12 PF00542.19 ETO04750.1 - 9.3e-22 77.2 12.6 1.7e-21 76.3 7.9 2.3 2 0 0 2 2 2 1 Ribosomal protein L7/L12 C-terminal domain Ribosomal_L12_N PF16320.5 ETO04750.1 - 3.4e-11 42.6 3.0 3.4e-11 42.6 3.0 2.4 2 0 0 2 2 2 1 Ribosomal protein L7/L12 dimerisation domain DUF4317 PF14199.6 ETO04750.1 - 0.0045 16.2 0.1 0.0079 15.4 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4317) ACP53EA PF06313.11 ETO04750.1 - 0.1 12.8 0.4 0.19 11.9 0.4 1.4 1 0 0 1 1 1 0 Drosophila ACP53EA protein Cauli_AT PF03233.13 ETO04750.1 - 0.17 11.8 4.0 0.19 11.6 0.2 2.0 2 0 0 2 2 2 0 Aphid transmission protein Ribosomal_60s PF00428.19 ETO04750.1 - 2.7 8.7 9.2 0.79 10.3 2.5 2.6 2 1 1 3 3 3 0 60s Acidic ribosomal protein Asn_synthase PF00733.21 ETO04751.1 - 1.8e-30 106.8 0.1 2.3e-30 106.5 0.1 1.0 1 0 0 1 1 1 1 Asparagine synthase SNARE PF05739.19 ETO04752.1 - 0.3 11.1 1.4 0.62 10.1 1.4 1.5 1 0 0 1 1 1 0 SNARE domain LRR_9 PF14580.6 ETO04755.1 - 7.4e-12 45.1 8.8 5.7e-11 42.2 5.6 2.5 2 0 0 2 2 2 1 Leucine-rich repeat LRR_4 PF12799.7 ETO04755.1 - 8.9e-09 35.5 19.7 0.00046 20.5 3.1 4.9 2 2 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO04755.1 - 2.7e-08 33.4 11.2 0.00016 21.4 0.7 4.0 2 2 1 3 3 3 3 Leucine rich repeat LRR_6 PF13516.6 ETO04755.1 - 0.0049 16.8 9.3 9.9 6.5 0.3 5.7 5 0 0 5 5 5 2 Leucine Rich repeat Alpha_kinase PF02816.18 ETO04755.1 - 0.062 13.4 0.3 0.062 13.4 0.3 2.1 2 1 0 2 2 2 0 Alpha-kinase family GvpG PF05120.12 ETO04757.1 - 0.065 13.3 1.9 0.11 12.6 1.9 1.3 1 0 0 1 1 1 0 Gas vesicle protein G DUF836 PF05768.14 ETO04757.1 - 0.094 13.1 0.3 0.38 11.2 0.1 1.9 1 1 1 2 2 2 0 Glutaredoxin-like domain (DUF836) TRAPP PF04051.16 ETO04757.1 - 0.12 12.1 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Transport protein particle (TRAPP) component ANAPC15 PF15243.6 ETO04758.1 - 0.0035 17.7 4.8 0.0064 16.9 4.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 15 WD40 PF00400.32 ETO04759.1 - 2e-19 69.5 14.7 1e-06 29.3 2.8 3.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO04759.1 - 4.9e-06 25.5 1.4 0.002 16.8 0.1 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04759.1 - 7.2e-06 26.2 0.0 0.0013 19.0 0.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain DUF5096 PF17019.5 ETO04759.1 - 0.03 14.1 0.9 0.15 11.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5096) FAM199X PF15814.5 ETO04762.1 - 0.43 9.6 18.8 0.69 8.9 18.8 1.3 1 0 0 1 1 1 0 Protein family FAM199X Lin-8 PF03353.15 ETO04762.1 - 0.44 10.1 12.1 0.52 9.8 12.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist PI3K_1B_p101 PF10486.9 ETO04762.1 - 3.8 5.2 17.2 5 4.8 17.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SPX PF03105.19 ETO04762.1 - 4.4 7.1 23.9 5.7 6.7 23.9 1.2 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 ETO04762.1 - 8 4.9 25.5 9 4.7 25.5 1.0 1 0 0 1 1 1 0 Macoilin family Apt1 PF10351.9 ETO04762.1 - 8.4 5.1 21.2 9.6 4.9 21.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S13 PF02113.15 ETO04763.1 - 0.097 11.4 0.0 0.11 11.3 0.0 1.0 1 0 0 1 1 1 0 D-Ala-D-Ala carboxypeptidase 3 (S13) family Ctr PF04145.15 ETO04765.1 - 0.061 13.9 1.2 0.19 12.3 1.2 1.7 1 1 0 1 1 1 0 Ctr copper transporter family ANAPC4_WD40 PF12894.7 ETO04766.1 - 0.061 13.6 0.0 6.2 7.2 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Cwf_Cwc_15 PF04889.12 ETO04769.1 - 0.04 13.7 12.6 0.053 13.2 12.6 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein mRNA_cap_C PF03919.15 ETO04770.1 - 5.1e-10 39.9 0.0 1.2e-09 38.7 0.0 1.7 1 0 0 1 1 1 1 mRNA capping enzyme, C-terminal domain Peptidase_M54 PF07998.11 ETO04771.1 - 9.4e-10 38.8 1.9 1.2e-09 38.4 1.9 1.1 1 0 0 1 1 1 1 Peptidase family M54 Reprolysin_4 PF13583.6 ETO04771.1 - 0.0049 16.5 0.1 0.0054 16.4 0.1 1.2 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Metallopep PF12044.8 ETO04771.1 - 0.023 13.3 0.1 0.023 13.3 0.1 1.2 1 0 0 1 1 1 0 Putative peptidase family Reprolysin_5 PF13688.6 ETO04771.1 - 0.04 14.1 0.8 0.061 13.5 0.4 1.5 1 1 1 2 2 2 0 Metallo-peptidase family M12 zf-MIZ PF02891.20 ETO04771.1 - 0.053 13.3 0.6 0.091 12.5 0.6 1.4 1 0 0 1 1 1 0 MIZ/SP-RING zinc finger Peptidase_M10 PF00413.24 ETO04771.1 - 0.069 13.0 0.2 0.1 12.5 0.2 1.3 1 0 0 1 1 1 0 Matrixin Peptidase_M57 PF12388.8 ETO04771.1 - 0.21 11.1 0.3 0.33 10.5 0.3 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Reprolysin_3 PF13582.6 ETO04771.1 - 0.52 10.8 1.7 1 9.9 1.7 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PP2C PF00481.21 ETO04772.1 - 4e-33 115.1 0.1 4.8e-33 114.9 0.1 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ETO04772.1 - 0.00015 21.7 0.0 0.00021 21.2 0.0 1.1 1 0 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ETO04772.1 - 0.0035 17.0 0.0 0.004 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2C Ribosomal_L14 PF00238.19 ETO04772.1 - 0.031 14.4 0.1 0.047 13.8 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L14p/L23e Kelch_4 PF13418.6 ETO04775.1 - 8.2e-06 25.7 0.3 0.00021 21.2 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO04775.1 - 0.00011 21.8 5.9 0.0072 15.9 0.5 3.8 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO04775.1 - 0.00018 21.6 1.0 15 6.1 0.0 4.2 4 0 0 4 4 4 3 Kelch motif RhoGAP-FF1 PF16512.5 ETO04775.1 - 0.11 13.1 1.2 0.39 11.4 0.2 2.3 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain Kelch_2 PF07646.15 ETO04775.1 - 0.14 12.2 6.0 43 4.3 1.9 4.7 4 1 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO04775.1 - 1 9.4 3.6 3.9 7.6 0.0 3.5 4 0 0 4 4 4 0 Kelch motif Inhibitor_I71 PF12628.7 ETO04776.1 - 0.02 14.7 2.4 0.02 14.7 2.4 1.5 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor Secretin_N_2 PF07655.13 ETO04776.1 - 0.99 10.0 9.3 1.9 9.1 9.3 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain WWE PF02825.20 ETO04777.1 - 0.017 15.7 0.7 0.034 14.7 0.7 1.6 1 0 0 1 1 1 0 WWE domain Exonuc_VII_L PF02601.15 ETO04778.1 - 0.0044 16.6 11.7 0.0056 16.3 11.7 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit Tropomyosin PF00261.20 ETO04778.1 - 0.0078 15.6 23.2 0.011 15.1 23.2 1.2 1 0 0 1 1 1 1 Tropomyosin SKA2 PF16740.5 ETO04778.1 - 0.01 15.6 6.6 0.01 15.6 6.6 2.6 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF1664 PF07889.12 ETO04778.1 - 0.02 14.9 14.3 0.071 13.2 7.1 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) STAT_alpha PF01017.20 ETO04778.1 - 0.045 13.6 20.9 0.059 13.3 18.6 2.0 1 1 1 2 2 2 0 STAT protein, all-alpha domain HAUS-augmin3 PF14932.6 ETO04778.1 - 0.19 11.3 20.7 0.31 10.6 20.7 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF5344 PF17279.2 ETO04778.1 - 0.2 12.2 12.1 0.073 13.7 3.0 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5344) CALCOCO1 PF07888.11 ETO04778.1 - 0.3 9.9 25.8 0.38 9.6 25.8 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Seryl_tRNA_N PF02403.22 ETO04778.1 - 0.34 11.2 23.8 1.7 8.9 15.2 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Nup88 PF10168.9 ETO04778.1 - 0.36 8.6 24.3 0.49 8.1 24.3 1.1 1 0 0 1 1 1 0 Nuclear pore component Laminin_II PF06009.12 ETO04778.1 - 0.43 10.6 12.0 0.16 12.0 7.1 2.1 1 1 1 2 2 2 0 Laminin Domain II Vps5 PF09325.10 ETO04778.1 - 0.56 9.7 18.5 0.33 10.4 3.9 2.3 1 1 1 2 2 2 0 Vps5 C terminal like APG6_N PF17675.1 ETO04778.1 - 0.59 10.7 26.3 0.3 11.6 23.1 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region TPR_MLP1_2 PF07926.12 ETO04778.1 - 0.81 9.8 24.9 1.8 8.6 10.8 2.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO04778.1 - 2 7.7 12.7 2.6 7.3 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nsp1_C PF05064.13 ETO04778.1 - 2.1 8.2 14.8 2.2 8.1 2.6 2.6 1 1 2 3 3 3 0 Nsp1-like C-terminal region CENP-F_leu_zip PF10473.9 ETO04778.1 - 2.2 8.3 29.4 2.9 7.9 20.9 2.2 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Polo_box_3 PF18544.1 ETO04778.1 - 2.4 8.8 7.1 1.4 9.6 3.1 2.2 1 1 1 2 2 2 0 Polo box domain GAS PF13851.6 ETO04778.1 - 2.6 7.4 30.7 2.3 7.5 21.4 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FapA PF03961.13 ETO04778.1 - 3.1 6.3 23.6 2.6 6.5 14.5 2.0 1 1 2 3 3 3 0 Flagellar Assembly Protein A DUF3450 PF11932.8 ETO04778.1 - 3.6 6.8 22.7 5.4 6.2 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Prefoldin_2 PF01920.20 ETO04778.1 - 4.5 7.3 28.6 2.6 8.1 3.1 3.4 2 1 0 2 2 2 0 Prefoldin subunit CREPT PF16566.5 ETO04778.1 - 6.5 6.9 18.8 3.2 7.9 12.0 2.2 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DASH_Spc19 PF08287.11 ETO04778.1 - 6.9 6.5 23.6 2.7 7.9 12.7 2.1 1 1 1 2 2 2 0 Spc19 Nup54 PF13874.6 ETO04778.1 - 7.3 6.7 21.4 14 5.8 5.0 2.2 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 WD40 PF00400.32 ETO04780.1 - 1.8e-22 79.2 12.3 4.5e-07 30.5 1.3 4.7 4 1 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO04780.1 - 5.4e-09 35.2 1.5 0.009 14.7 0.2 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04780.1 - 3.6e-07 30.4 0.1 0.075 13.3 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04780.1 - 2e-05 24.1 0.4 0.001 18.5 0.1 2.3 1 1 1 2 2 2 2 WD40-like domain DEP PF00610.21 ETO04781.1 - 2.3e-15 56.4 0.2 3.8e-15 55.7 0.2 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) KH_8 PF17903.1 ETO04782.1 - 0.11 12.6 0.1 0.16 12.1 0.1 1.2 1 0 0 1 1 1 0 Krr1 KH1 domain Ctr PF04145.15 ETO04786.1 - 0.014 16.1 0.9 0.03 15.0 0.9 1.8 1 1 0 1 1 1 0 Ctr copper transporter family Chordopox_L2 PF05803.12 ETO04786.1 - 0.11 12.3 0.3 0.11 12.3 0.3 3.0 4 0 0 4 4 4 0 Chordopoxvirus L2 protein CAP_GLY PF01302.25 ETO04787.1 - 2.1e-18 66.1 0.2 4.1e-18 65.2 0.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain Phostensin_N PF13916.6 ETO04787.1 - 0.41 11.0 2.5 0.87 10.0 2.5 1.5 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal EBP50_C PF09007.11 ETO04787.1 - 0.53 11.3 2.7 8.4 7.4 0.1 3.1 3 0 0 3 3 3 0 EBP50, C-terminal SUIM_assoc PF16619.5 ETO04787.1 - 1.1 9.3 11.3 1.2 9.2 5.5 2.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Med9 PF07544.13 ETO04788.1 - 0.0078 16.3 7.6 0.0078 16.3 7.6 2.9 2 1 1 3 3 3 1 RNA polymerase II transcription mediator complex subunit 9 DUF2524 PF10732.9 ETO04788.1 - 0.03 14.6 2.6 0.03 14.6 2.6 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2524) ATG16 PF08614.11 ETO04788.1 - 0.056 13.7 30.5 19 5.4 23.9 3.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ETO04788.1 - 0.38 9.6 26.4 2.1 7.2 11.7 2.9 1 1 2 3 3 3 0 Spc7 kinetochore protein PKcGMP_CC PF16808.5 ETO04788.1 - 0.58 10.0 7.8 7.5 6.5 1.5 3.1 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase LHH PF14411.6 ETO04788.1 - 1 9.6 8.8 0.22 11.7 0.4 3.4 1 1 3 4 4 4 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH CC2-LZ PF16516.5 ETO04788.1 - 2 8.8 22.1 2.4 8.6 6.8 3.8 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF16 PF01519.16 ETO04788.1 - 5.1 7.6 20.6 5.5 7.5 10.3 3.3 1 1 1 2 2 2 0 Protein of unknown function DUF16 Phage_lysis PF03245.13 ETO04788.1 - 6.3 6.9 8.9 0.92 9.6 3.2 2.5 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein WD40 PF00400.32 ETO04789.1 - 2.9e-08 34.2 1.9 0.0047 17.7 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04789.1 - 0.0053 15.5 0.5 0.5 8.9 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Pho86 PF11124.8 ETO04789.1 - 0.011 15.3 1.5 0.01 15.3 1.5 1.1 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 DUF3870 PF12986.7 ETO04789.1 - 0.17 12.1 0.9 0.24 11.7 0.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3870) PBP1_TM PF14812.6 ETO04793.1 - 1.2 9.5 10.7 3.7 8.0 10.7 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UPF0086 PF01868.16 ETO04795.1 - 4.4e-05 23.3 0.7 9.7e-05 22.2 0.0 2.0 2 0 0 2 2 2 1 Domain of unknown function UPF0086 Menin PF05053.13 ETO04796.1 - 0.084 11.2 16.2 0.1 11.0 16.2 1.1 1 0 0 1 1 1 0 Menin PI3K_1B_p101 PF10486.9 ETO04796.1 - 0.44 8.3 8.7 0.46 8.2 8.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GREB1 PF15782.5 ETO04796.1 - 3.7 4.6 13.2 4.4 4.3 13.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ank_2 PF12796.7 ETO04797.1 - 4.7e-42 142.5 3.1 7e-16 58.6 0.2 4.1 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO04797.1 - 1e-30 105.7 1.2 5.9e-08 33.1 0.0 6.9 2 2 5 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 ETO04797.1 - 4.4e-27 93.3 6.0 0.00022 21.5 0.1 7.7 8 0 0 8 8 8 5 Ankyrin repeat Ank_5 PF13857.6 ETO04797.1 - 4.2e-24 84.3 5.2 2.8e-05 24.3 0.1 7.4 2 2 6 8 8 8 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO04797.1 - 1.7e-23 80.2 2.7 0.0016 18.7 0.1 8.7 9 0 0 9 9 9 5 Ankyrin repeat Ank_2 PF12796.7 ETO04798.1 - 3e-05 24.5 0.0 4.4e-05 24.0 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO04798.1 - 5e-05 23.5 0.2 0.00017 21.9 0.1 1.9 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO04798.1 - 5.5e-05 23.4 0.0 9.9e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO04798.1 - 0.00013 22.1 0.1 0.0029 18.0 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO04798.1 - 0.00031 21.2 0.0 0.0018 18.8 0.0 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO04799.1 - 1.7e-10 41.2 0.5 3.7e-06 27.4 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO04799.1 - 3.4e-09 36.8 0.6 1.1e-05 25.6 0.3 2.7 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO04799.1 - 1.7e-08 34.9 0.3 2.7e-08 34.3 0.3 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO04799.1 - 0.073 13.6 2.0 8.9 7.0 0.1 2.5 2 0 0 2 2 2 0 Ankyrin repeat RGS PF00615.19 ETO04800.1 - 0.027 14.7 0.1 0.051 13.8 0.1 1.4 1 0 0 1 1 1 0 Regulator of G protein signaling domain Kelch_2 PF07646.15 ETO04801.1 - 0.0026 17.7 0.1 0.0068 16.3 0.0 1.7 2 0 0 2 2 2 1 Kelch motif Consortin_C PF15281.6 ETO04801.1 - 0.055 13.5 0.3 0.055 13.5 0.3 2.7 2 1 1 3 3 3 0 Consortin C-terminus MDFI PF15316.6 ETO04801.1 - 0.93 9.6 7.9 2.2 8.4 7.9 1.8 1 1 0 1 1 1 0 MyoD family inhibitor A_deaminase PF00962.22 ETO04802.1 - 0.0086 15.4 0.0 0.0086 15.4 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_2 PF04909.14 ETO04802.1 - 0.13 12.0 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 Amidohydrolase SprA-related PF12118.8 ETO04803.1 - 0.28 10.3 16.2 0.4 9.8 16.2 1.2 1 0 0 1 1 1 0 SprA-related family Menin PF05053.13 ETO04803.1 - 1.3 7.3 16.2 1.4 7.2 16.2 1.1 1 0 0 1 1 1 0 Menin Ndc1_Nup PF09531.10 ETO04803.1 - 2.2 6.9 13.6 2.5 6.7 13.6 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ALMT PF11744.8 ETO04803.1 - 3.6 6.3 12.8 3.9 6.2 12.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Pneumo_att_G PF05539.11 ETO04803.1 - 5.1 6.6 16.2 6 6.4 16.2 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G SRP-alpha_N PF04086.13 ETO04803.1 - 8.8 6.2 20.3 11 5.9 20.3 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal TRAP_alpha PF03896.16 ETO04804.1 - 0.033 13.4 1.5 0.035 13.3 1.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4746 PF15928.5 ETO04804.1 - 0.077 12.4 8.9 0.09 12.2 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Shisa PF13908.6 ETO04804.1 - 0.15 12.3 0.2 0.2 11.9 0.2 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator GOLD_2 PF13897.6 ETO04804.1 - 0.18 12.3 1.6 0.24 11.9 1.6 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Nop14 PF04147.12 ETO04804.1 - 0.55 8.4 6.8 0.58 8.3 6.8 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO04804.1 - 0.57 9.6 8.2 0.7 9.3 8.2 1.0 1 0 0 1 1 1 0 SDA1 Radial_spoke PF04712.12 ETO04804.1 - 0.75 8.7 11.5 0.97 8.3 11.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein RRN3 PF05327.11 ETO04804.1 - 2.2 6.7 5.2 2.5 6.5 5.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETO04804.1 - 2.7 6.2 4.7 3 6.0 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ETO04804.1 - 2.7 6.5 8.2 3.1 6.3 8.2 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ETO04804.1 - 3.8 5.5 11.0 4.8 5.2 11.0 1.0 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO04804.1 - 7.2 5.8 9.5 8.3 5.6 9.5 1.1 1 0 0 1 1 1 0 NOA36 protein YcxB PF14317.6 ETO04805.1 - 0.0051 16.5 0.1 0.1 12.3 0.0 2.3 2 0 0 2 2 2 1 YcxB-like protein PUB PF09409.10 ETO04806.1 - 0.052 13.5 2.6 0.22 11.5 1.5 2.6 2 1 0 2 2 2 0 PUB domain Folate_rec PF03024.14 ETO04806.1 - 0.064 13.1 1.7 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Folate receptor family SHS2_Rpb7-N PF03876.17 ETO04809.1 - 0.12 12.8 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 GREB1 PF15782.5 ETO04809.1 - 0.42 7.7 8.2 0.43 7.6 8.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RPA43_OB PF17875.1 ETO04809.1 - 0.99 10.0 0.0 0.99 10.0 0.0 4.2 2 1 0 3 3 3 0 RPA43 OB domain in RNA Pol I BSP_II PF05432.11 ETO04809.1 - 7.8 6.1 37.0 11 5.6 37.0 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Usp PF00582.26 ETO04810.1 - 2.7e-05 24.7 0.1 5e-05 23.8 0.1 1.4 1 0 0 1 1 1 1 Universal stress protein family Usp PF00582.26 ETO04811.1 - 3.9e-17 63.1 0.0 4e-17 63.1 0.0 1.2 1 0 0 1 1 1 1 Universal stress protein family CbiX PF01903.17 ETO04811.1 - 0.11 12.8 0.0 4 7.8 0.0 2.0 1 1 1 2 2 2 0 CbiX Exo_endo_phos_2 PF14529.6 ETO04812.1 - 1.6e-08 34.4 0.1 3.1e-08 33.5 0.1 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO04812.1 - 0.024 14.2 0.0 0.026 14.0 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF3413 PF11893.8 ETO04813.1 - 0.58 9.3 7.4 0.52 9.4 4.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3413) Closter_coat PF01785.17 ETO04814.1 - 0.032 13.5 0.2 0.086 12.1 0.2 1.9 1 1 0 1 1 1 0 Closterovirus coat protein HEPN-like_int PF18867.1 ETO04814.1 - 0.069 13.0 1.4 0.076 12.9 0.2 1.7 2 0 0 2 2 2 0 HEPN-like integron domain Dynein_light PF01221.18 ETO04815.1 - 2.9e-34 117.2 1.0 4.5e-34 116.6 1.0 1.3 1 0 0 1 1 1 1 Dynein light chain type 1 Cpn60_TCP1 PF00118.24 ETO04817.1 - 1.2e-23 83.6 0.6 5.6e-23 81.3 0.6 1.8 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family DIMCO_N PF16844.5 ETO04817.1 - 0.056 13.8 0.1 0.14 12.5 0.1 1.7 1 0 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor, N-terminal TrmE_N PF10396.9 ETO04817.1 - 0.12 12.7 0.3 5.8 7.3 0.0 2.5 3 0 0 3 3 3 0 GTP-binding protein TrmE N-terminus RPEL PF02755.15 ETO04819.1 - 0.0002 20.9 0.4 0.00065 19.3 0.4 1.9 1 0 0 1 1 1 1 RPEL repeat DUF4471 PF14740.6 ETO04819.1 - 2.6 7.2 8.7 1.6 7.9 3.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4471) KASH_CCD PF14662.6 ETO04820.1 - 2.2e-05 24.4 10.9 0.0011 18.9 6.6 2.1 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.7 ETO04820.1 - 0.0014 18.8 5.4 0.0014 18.8 5.4 2.2 2 0 0 2 2 2 1 Tropomyosin like Lzipper-MIP1 PF14389.6 ETO04820.1 - 0.0076 16.5 0.2 0.0076 16.5 0.2 2.8 3 1 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 Mod_r PF07200.13 ETO04820.1 - 0.0091 16.1 6.1 0.011 15.8 2.8 2.0 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein Cnn_1N PF07989.11 ETO04820.1 - 0.011 15.8 5.3 0.011 15.8 5.3 2.6 3 0 0 3 3 2 0 Centrosomin N-terminal motif 1 MCC-bdg_PDZ PF10506.9 ETO04820.1 - 0.018 15.0 4.6 0.065 13.3 1.4 2.2 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF5082 PF16888.5 ETO04820.1 - 0.028 14.7 1.6 0.51 10.6 0.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) DUF496 PF04363.12 ETO04820.1 - 0.029 14.4 5.6 0.038 14.0 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF496) MAD PF05557.13 ETO04820.1 - 0.039 12.3 11.3 1.1 7.6 7.9 2.0 2 0 0 2 2 2 0 Mitotic checkpoint protein Fmp27_WPPW PF10359.9 ETO04820.1 - 0.062 12.1 6.9 0.012 14.5 3.5 1.5 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DivIC PF04977.15 ETO04820.1 - 0.091 12.5 12.6 0.63 9.9 1.0 3.4 3 1 1 4 4 3 0 Septum formation initiator DUF4407 PF14362.6 ETO04820.1 - 0.1 11.9 2.2 0.11 11.8 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Allexi_40kDa PF05549.11 ETO04820.1 - 0.11 11.9 1.7 0.11 12.0 1.1 1.4 1 1 0 1 1 1 0 Allexivirus 40kDa protein Cep57_CLD PF14073.6 ETO04820.1 - 0.2 11.7 10.9 0.24 11.4 6.4 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 TMF_DNA_bd PF12329.8 ETO04820.1 - 0.22 11.6 16.0 0.14 12.1 7.7 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Snapin_Pallidin PF14712.6 ETO04820.1 - 0.31 11.5 12.9 0.15 12.5 6.2 2.2 2 0 0 2 2 2 0 Snapin/Pallidin KLRAQ PF10205.9 ETO04820.1 - 0.35 11.1 7.7 0.069 13.4 3.1 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein TolA_bind_tri PF16331.5 ETO04820.1 - 0.36 10.9 7.7 0.27 11.3 2.9 2.3 2 0 0 2 2 2 0 TolA binding protein trimerisation Sec2p PF06428.11 ETO04820.1 - 0.41 10.6 8.8 0.86 9.6 3.7 2.5 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p PHM7_cyt PF14703.6 ETO04820.1 - 0.64 10.2 5.0 1 9.6 5.0 1.4 1 1 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Tropomyosin PF00261.20 ETO04820.1 - 1.1 8.6 14.5 0.11 11.8 6.9 2.0 2 0 0 2 2 2 0 Tropomyosin ADIP PF11559.8 ETO04820.1 - 1.1 9.3 9.3 0.3 11.2 4.8 2.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-H PF05837.12 ETO04820.1 - 1.4 9.4 8.6 1.5 9.3 4.1 2.2 2 0 0 2 2 2 0 Centromere protein H (CENP-H) APG6_N PF17675.1 ETO04820.1 - 2.3 8.8 10.8 0.41 11.2 1.1 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region ZapB PF06005.12 ETO04820.1 - 2.6 8.6 16.1 13 6.3 9.5 2.6 2 1 0 2 2 2 0 Cell division protein ZapB DHR10 PF18595.1 ETO04820.1 - 2.7 8.1 13.3 0.31 11.1 6.8 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain CCDC-167 PF15188.6 ETO04820.1 - 3 8.3 9.9 9.7 6.6 0.1 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 BST2 PF16716.5 ETO04820.1 - 3.4 8.3 10.0 0.48 11.1 4.6 2.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 ATG16 PF08614.11 ETO04820.1 - 4.4 7.5 16.4 11 6.2 10.0 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF724 PF05266.14 ETO04820.1 - 5.1 6.9 8.9 14 5.4 3.3 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF724) 3-PAP PF12578.8 ETO04820.1 - 6.2 6.6 8.6 8.4 6.1 0.1 3.3 3 1 0 3 3 3 0 Myotubularin-associated protein DndE PF08870.11 ETO04821.1 - 0.028 14.7 2.3 0.035 14.4 0.5 1.8 1 1 1 2 2 2 0 DNA sulphur modification protein DndE Ank_2 PF12796.7 ETO04822.1 - 0.00076 20.0 0.0 0.001 19.6 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO04822.1 - 0.0075 16.7 0.1 0.17 12.5 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ETO04822.1 - 0.013 15.9 0.0 0.76 10.3 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat AMP_N PF05195.16 ETO04822.1 - 0.045 13.5 0.1 0.068 12.9 0.1 1.5 1 1 0 1 1 1 0 Aminopeptidase P, N-terminal domain DUF3913 PF13052.6 ETO04822.1 - 0.073 13.3 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3913) YfdX PF10938.8 ETO04822.1 - 0.081 12.8 0.2 0.11 12.4 0.2 1.2 1 0 0 1 1 1 0 YfdX protein Apis_Csd PF11671.8 ETO04823.1 - 0.047 13.7 7.6 0.08 12.9 7.6 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein T4_Gp59_N PF08993.10 ETO04824.1 - 0.068 13.6 0.1 0.1 13.0 0.1 1.3 1 0 0 1 1 1 0 T4 gene Gp59 loader of gp41 DNA helicase SGL PF08450.12 ETO04825.1 - 5.5e-09 36.0 0.1 6.4e-08 32.5 0.1 2.6 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ETO04825.1 - 0.026 14.6 2.7 16 5.8 0.0 4.8 5 0 0 5 5 5 0 NHL repeat PARG_cat PF05028.14 ETO04826.1 - 0.24 10.6 5.1 0.32 10.2 4.8 1.4 2 0 0 2 2 2 0 Poly (ADP-ribose) glycohydrolase (PARG) NUMOD3 PF07460.11 ETO04827.1 - 0.0018 18.5 1.2 0.0033 17.6 1.2 1.5 1 0 0 1 1 1 1 NUMOD3 motif (2 copies) GyrB_insert PF18053.1 ETO04827.1 - 0.018 14.9 0.1 0.02 14.8 0.1 1.1 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain Abhydrolase_1 PF00561.20 ETO04828.1 - 6.2e-06 26.0 0.0 0.013 15.2 0.0 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO04828.1 - 9.6e-05 21.8 0.0 0.41 9.9 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 RR_TM4-6 PF06459.12 ETO04828.1 - 0.011 15.6 1.0 0.015 15.1 1.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Abhydrolase_2 PF02230.16 ETO04828.1 - 0.025 14.4 0.2 1 9.1 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase FSH1 PF03959.13 ETO04828.1 - 0.048 13.3 0.0 0.37 10.4 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) HeH PF12949.7 ETO04828.1 - 0.085 12.6 0.2 0.17 11.6 0.2 1.5 1 0 0 1 1 1 0 HeH/LEM domain Abhydrolase_6 PF12697.7 ETO04828.1 - 0.14 12.7 0.0 0.33 11.5 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family Nop14 PF04147.12 ETO04828.1 - 0.15 10.3 10.5 0.18 10.0 10.5 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO04828.1 - 0.23 9.7 8.9 0.27 9.5 8.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO04828.1 - 0.7 8.4 8.6 0.9 8.0 8.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO04828.1 - 0.89 7.6 20.4 1.2 7.2 12.7 2.0 2 0 0 2 2 2 0 DNA polymerase phi DUF3931 PF13082.6 ETO04829.1 - 1.5 9.0 4.6 0.65 10.2 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3931) Hydrolase_6 PF13344.6 ETO04830.1 - 0.44 10.7 3.0 0.62 10.2 1.7 1.9 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase WD40 PF00400.32 ETO04831.1 - 4.3e-08 33.7 3.6 0.007 17.2 0.1 4.0 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04831.1 - 0.012 15.8 0.7 0.15 12.3 0.2 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04831.1 - 0.096 11.3 0.8 0.5 8.9 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Spindle_Spc25 PF08234.12 ETO04832.1 - 3.1 8.1 6.8 19 5.5 0.2 3.4 3 0 0 3 3 3 0 Chromosome segregation protein Spc25 HAD PF12710.7 ETO04834.1 - 0.044 14.2 0.1 0.055 13.9 0.1 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase WD40 PF00400.32 ETO04835.1 - 0.0054 17.6 1.4 0.023 15.6 0.3 2.3 2 1 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO04837.1 - 0.00032 21.4 0.8 0.0084 17.0 0.9 2.9 3 1 0 3 3 3 1 WD domain, G-beta repeat Arg_repressor PF01316.21 ETO04837.1 - 0.056 13.2 0.1 0.1 12.3 0.1 1.4 1 0 0 1 1 1 0 Arginine repressor, DNA binding domain DUF924 PF06041.11 ETO04839.1 - 7.3e-54 182.6 3.0 1.5e-53 181.6 3.0 1.6 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) Peptidase_M15 PF01427.17 ETO04839.1 - 6.9e-32 110.8 0.2 5.2e-30 104.7 0.1 2.3 1 1 1 2 2 2 2 D-ala-D-ala dipeptidase RT_RNaseH PF17917.1 ETO04839.1 - 0.016 15.5 0.0 0.04 14.2 0.0 1.7 1 0 0 1 1 1 0 RNase H-like domain found in reverse transcriptase Baculo_RING PF05883.11 ETO04839.1 - 0.17 11.9 1.3 13 5.8 0.3 2.5 2 0 0 2 2 2 0 Baculovirus U-box/Ring-like domain GcpE PF04551.14 ETO04840.1 - 4.3e-08 32.7 0.0 6.8e-08 32.0 0.0 1.3 1 0 0 1 1 1 1 GcpE protein MID_MedPIWI PF18296.1 ETO04841.1 - 0.21 11.4 16.5 0.041 13.7 2.7 2.3 2 0 0 2 2 2 0 MID domain of medPIWI Corazonin PF17308.2 ETO04841.1 - 2.8 8.3 26.0 0.06 13.7 9.3 3.2 3 0 0 3 3 3 0 Pro-corazonin Secretin_N_2 PF07655.13 ETO04841.1 - 5 7.7 30.7 1.3 9.6 14.3 2.8 3 0 0 3 3 3 0 Secretin N-terminal domain DUF502 PF04367.13 ETO04842.1 - 0.039 13.8 0.1 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF502) PRD PF00874.20 ETO04842.1 - 0.66 10.3 4.0 2.9 8.2 0.1 2.7 2 0 0 2 2 2 0 PRD domain DUF1104 PF06518.11 ETO04842.1 - 2.4 8.6 10.2 1.1 9.7 2.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1104) Ank_5 PF13857.6 ETO04843.1 - 0.00016 21.9 0.0 0.0026 18.0 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO04843.1 - 0.0025 18.3 0.5 0.082 13.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO04843.1 - 0.058 14.0 0.0 0.067 13.8 0.0 1.2 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO04844.1 - 7.7e-07 29.5 0.0 0.00012 22.6 0.0 2.7 1 1 2 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO04844.1 - 7.7e-06 26.4 0.0 0.00021 21.8 0.0 2.1 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO04844.1 - 0.0044 17.4 0.0 27 5.8 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO04844.1 - 0.0063 16.8 0.0 0.069 13.5 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO04844.1 - 0.017 15.6 0.1 11 6.7 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat Peptidase_C14 PF00656.22 ETO04845.1 - 1.9e-16 60.8 0.2 2.9e-16 60.2 0.2 1.3 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 ETO04846.1 - 8.2e-06 25.9 7.2 3e-05 24.1 7.2 1.9 1 1 0 1 1 1 1 Caspase domain DUF1514 PF07438.11 ETO04846.1 - 0.028 14.3 2.8 0.039 13.8 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1514) IMP2_N PF18590.1 ETO04846.1 - 0.054 14.1 0.5 0.29 11.7 0.7 2.0 2 0 0 2 2 2 0 Immune Mapped Protein 2 (IMP2) N-terminal domain Linker_histone PF00538.19 ETO04846.1 - 0.84 10.1 4.4 7.3 7.0 0.2 2.7 2 1 0 2 2 2 0 linker histone H1 and H5 family Kelch_6 PF13964.6 ETO04848.1 - 0.00067 19.9 1.6 1.1 9.6 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO04849.1 - 0.071 13.1 2.0 39 4.4 0.1 4.1 4 0 0 4 4 4 0 Kelch motif RelA_SpoT PF04607.17 ETO04850.1 - 0.0024 18.1 1.7 0.0024 18.1 1.7 2.0 1 1 0 2 2 2 1 Region found in RelA / SpoT proteins WD40 PF00400.32 ETO04851.1 - 4.9e-10 39.8 1.0 0.0031 18.3 0.1 3.9 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04851.1 - 0.00038 19.3 0.1 0.44 9.1 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO04851.1 - 0.0011 17.8 0.3 0.0017 17.2 0.3 1.3 1 0 0 1 1 1 1 Nup133 N terminal like FPL PF09758.9 ETO04852.1 - 0.0003 20.8 1.4 0.26 11.3 0.2 2.4 1 1 1 2 2 2 2 Uncharacterised conserved protein UPF0223 PF05256.12 ETO04852.1 - 0.0023 18.2 0.6 0.51 10.7 0.1 2.4 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0223) Imm70 PF15601.6 ETO04852.1 - 0.0089 15.6 0.3 0.22 11.1 0.0 2.3 1 1 1 2 2 2 1 Immunity protein 70 DUF3600 PF12207.8 ETO04852.1 - 0.039 13.9 2.0 1.2 9.0 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3600) IPK PF03770.16 ETO04852.1 - 0.041 13.8 0.8 0.22 11.3 0.3 1.8 1 1 1 2 2 2 0 Inositol polyphosphate kinase Anticodon_1 PF08264.13 ETO04852.1 - 0.53 10.2 3.2 13 5.7 0.2 2.5 1 1 2 3 3 3 0 Anticodon-binding domain of tRNA Methyltransf_16 PF10294.9 ETO04853.1 - 0.062 13.0 1.4 0.072 12.8 1.0 1.4 1 1 0 1 1 1 0 Lysine methyltransferase UCH PF00443.29 ETO04854.1 - 8.3e-44 150.0 0.8 8.3e-44 150.0 0.8 2.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO04854.1 - 1.5e-28 100.3 1.0 1.5e-28 100.3 1.0 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Imm70 PF15601.6 ETO04854.1 - 0.022 14.3 0.0 0.055 13.0 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 70 MtrG PF04210.13 ETO04854.1 - 0.096 12.6 0.1 0.26 11.2 0.1 1.7 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit G Peptidase_C14 PF00656.22 ETO04855.1 - 1.8e-11 44.5 0.2 1.8e-11 44.5 0.2 2.7 2 1 1 3 3 3 1 Caspase domain Kelch_1 PF01344.25 ETO04855.1 - 4.9e-05 22.8 3.0 0.18 11.4 0.2 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO04855.1 - 0.00058 20.0 5.7 0.63 10.4 0.0 4.7 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 ETO04855.1 - 0.00062 19.6 9.5 0.0072 16.3 0.1 5.7 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 ETO04855.1 - 0.0079 16.2 0.6 0.38 10.8 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO04855.1 - 0.039 14.3 1.4 0.48 10.8 0.0 3.3 4 0 0 4 4 4 0 Galactose oxidase, central domain FAM176 PF14851.6 ETO04855.1 - 0.48 10.1 13.8 1.6 8.4 13.8 1.8 1 0 0 1 1 1 0 FAM176 family DUF4245 PF14030.6 ETO04858.1 - 0.5 10.4 4.9 0.71 9.9 4.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4245) CENP-B_dimeris PF09026.10 ETO04859.1 - 0.0014 19.0 35.3 0.0052 17.2 2.1 3.4 2 1 1 3 3 3 3 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO04859.1 - 0.026 14.2 0.7 0.026 14.2 0.7 3.1 2 1 1 3 3 3 0 FAM176 family Ribosomal_60s PF00428.19 ETO04859.1 - 0.05 14.2 8.0 0.05 14.2 8.0 3.1 3 1 0 3 3 3 0 60s Acidic ribosomal protein SDA1 PF05285.12 ETO04859.1 - 0.057 12.8 27.8 0.38 10.1 17.8 2.0 2 0 0 2 2 2 0 SDA1 Conotoxin PF02950.17 ETO04859.1 - 3.3 8.8 9.3 3.6 8.7 0.0 3.2 3 0 0 3 3 3 0 Conotoxin Nop14 PF04147.12 ETO04859.1 - 5.4 5.1 30.3 0.84 7.8 16.1 2.0 2 0 0 2 2 2 0 Nop14-like family DNA_pol_phi PF04931.13 ETO04859.1 - 6.5 4.7 30.7 1 7.4 15.8 2.1 2 0 0 2 2 2 0 DNA polymerase phi ANAPC15 PF15243.6 ETO04859.1 - 6.6 7.2 36.3 2.9 8.3 6.0 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 15 Imm5 PF14423.6 ETO04859.1 - 9.7 6.4 14.3 13 6.0 10.3 2.1 2 0 0 2 2 2 0 Immunity protein Imm5 WD40 PF00400.32 ETO04860.1 - 1.4e-05 25.7 0.8 0.00063 20.5 0.1 3.0 2 1 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO04861.1 - 1.5e-11 44.6 4.6 1.6e-05 25.5 0.2 3.5 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04861.1 - 0.1 11.2 0.1 0.39 9.3 0.0 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Rav1p_C PF12234.8 ETO04862.1 - 1.1e-55 189.3 11.4 2.2e-55 188.3 11.4 1.4 1 0 0 1 1 1 1 RAVE protein 1 C terminal Atrophin-1 PF03154.15 ETO04862.1 - 7.9 4.6 7.7 0.25 9.6 0.5 1.9 2 0 0 2 2 2 0 Atrophin-1 family WD40 PF00400.32 ETO04863.1 - 2.6e-70 230.6 10.8 1.7e-09 38.1 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04863.1 - 1.3e-25 89.5 0.5 0.0011 19.2 0.0 6.6 1 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04863.1 - 6.9e-20 71.3 0.0 0.0071 15.3 0.0 6.9 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO04863.1 - 6.8e-09 35.5 0.0 0.00018 20.9 0.0 3.3 2 2 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO04863.1 - 1.5e-08 34.4 0.8 1.6 8.7 0.0 6.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO04863.1 - 1.7e-08 34.6 0.0 0.00078 19.4 0.0 3.2 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO04863.1 - 1.2e-06 28.1 2.0 2 7.7 0.0 5.2 1 1 5 6 6 6 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO04863.1 - 2.6e-06 26.4 4.4 0.21 10.2 0.0 4.7 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO04863.1 - 5.4e-05 22.1 1.7 0.45 9.2 0.1 4.5 1 1 4 5 5 5 2 Nup133 N terminal like Frtz PF11768.8 ETO04863.1 - 0.00022 19.7 0.1 0.2 10.0 0.0 2.9 1 1 2 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 ETO04863.1 - 0.0059 15.2 0.1 2.8 6.4 0.0 2.9 1 1 1 3 3 3 2 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO04863.1 - 0.014 15.1 14.1 6.4 6.6 0.1 6.0 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Roc PF08477.13 ETO04863.1 - 0.068 13.4 2.7 10 6.4 0.1 3.7 3 1 1 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase Utp8 PF10395.9 ETO04863.1 - 0.074 11.5 0.0 0.68 8.4 0.0 2.1 2 1 0 2 2 2 0 Utp8 family DUF5570 PF17731.1 ETO04863.1 - 0.12 12.5 2.7 14 5.8 0.1 3.8 2 2 3 5 5 5 0 Family of unknown function (DUF5570) Phage_CI_repr PF07022.13 ETO04863.1 - 0.43 10.7 1.8 18 5.5 0.0 3.3 4 0 0 4 4 3 0 Bacteriophage CI repressor helix-turn-helix domain SapC PF07277.11 ETO04865.1 - 0.049 13.2 0.1 0.092 12.3 0.1 1.4 1 0 0 1 1 1 0 SapC PDZ_2 PF13180.6 ETO04865.1 - 0.05 13.9 0.1 0.095 13.0 0.1 1.5 1 0 0 1 1 1 0 PDZ domain DUF3490 PF11995.8 ETO04865.1 - 1 9.2 4.3 1.1 9.0 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3490) Osteopontin PF00865.18 ETO04866.1 - 0.0044 16.5 14.1 0.0044 16.5 14.1 1.1 1 0 0 1 1 1 1 Osteopontin CDC45 PF02724.14 ETO04866.1 - 0.055 11.8 10.5 0.056 11.7 10.5 1.0 1 0 0 1 1 1 0 CDC45-like protein GCIP PF13324.6 ETO04866.1 - 0.15 11.6 7.8 0.16 11.6 7.8 1.1 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Sigma70_ner PF04546.13 ETO04866.1 - 0.43 10.4 10.1 0.52 10.2 10.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 ETO04866.1 - 0.82 7.8 17.5 0.89 7.7 17.5 1.0 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.5 ETO04866.1 - 1 9.1 6.9 1.2 8.9 6.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Pox_Ag35 PF03286.14 ETO04866.1 - 2.4 7.9 10.0 3.1 7.5 10.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SspB PF04386.13 ETO04866.1 - 3 7.7 5.5 3.6 7.5 5.5 1.1 1 0 0 1 1 1 0 Stringent starvation protein B NOA36 PF06524.12 ETO04866.1 - 3.3 7.0 19.0 4.1 6.6 19.0 1.2 1 0 0 1 1 1 0 NOA36 protein YL1 PF05764.13 ETO04866.1 - 4.9 7.2 17.3 6.2 6.9 17.3 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Sporozoite_P67 PF05642.11 ETO04866.1 - 5.2 5.0 10.3 6 4.8 10.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2722 PF10846.8 ETO04866.1 - 7 5.5 12.0 7.5 5.4 12.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pes-10 PF07149.11 ETO04866.1 - 8.5 5.3 21.6 11 5.0 21.6 1.1 1 0 0 1 1 1 0 Pes-10 Dynein_C PF18199.1 ETO04867.1 - 4.1e-79 266.0 0.1 8.1e-79 265.0 0.1 1.5 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETO04867.1 - 1.4e-55 187.6 0.4 2.2e-55 186.9 0.4 1.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ETO04867.1 - 4.7e-31 107.3 0.1 1.2e-30 106.0 0.1 1.8 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain PilI PF10623.9 ETO04867.1 - 0.047 13.8 0.0 0.91 9.7 0.0 2.4 2 0 0 2 2 2 0 Plasmid conjugative transfer protein PilI AAA_9 PF12781.7 ETO04868.1 - 6e-74 247.9 0.4 6e-74 247.9 0.4 2.3 2 0 0 2 2 2 1 ATP-binding dynein motor region MT PF12777.7 ETO04868.1 - 2e-39 135.6 3.1 3.2e-39 134.9 3.1 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Laminin_II PF06009.12 ETO04868.1 - 0.0054 16.7 2.7 0.0054 16.7 2.7 2.2 2 0 0 2 2 2 1 Laminin Domain II PRF PF06875.11 ETO04868.1 - 0.078 12.4 0.3 0.16 11.3 0.3 1.5 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF Coiled-coil_56 PF09813.9 ETO04868.1 - 0.089 12.8 0.1 0.32 11.1 0.1 1.9 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 DUF4164 PF13747.6 ETO04868.1 - 0.23 11.8 10.3 0.026 14.8 3.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) BRE1 PF08647.11 ETO04868.1 - 0.29 11.2 13.7 0.29 11.2 5.2 3.3 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase Fez1 PF06818.15 ETO04868.1 - 0.46 10.9 8.7 0.045 14.2 1.2 2.3 2 0 0 2 2 2 0 Fez1 Sec8_exocyst PF04048.14 ETO04868.1 - 0.8 9.6 6.7 8 6.3 0.5 3.5 2 1 1 3 3 3 0 Sec8 exocyst complex component specific domain SKA2 PF16740.5 ETO04868.1 - 1.7 8.5 8.2 0.22 11.3 1.8 2.6 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 FapA PF03961.13 ETO04868.1 - 5.8 5.4 9.5 1 7.9 3.2 2.1 2 0 0 2 2 2 0 Flagellar Assembly Protein A FliD_N PF02465.18 ETO04868.1 - 8.5 7.1 7.9 1.7 9.4 1.1 2.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus TMF_DNA_bd PF12329.8 ETO04868.1 - 9.9 6.2 18.7 0.31 11.1 10.9 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding AAA_6 PF12774.7 ETO04869.1 - 2.3e-103 345.6 6.8 2.3e-103 345.6 6.8 3.4 3 1 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region AAA_8 PF12780.7 ETO04869.1 - 1e-96 323.2 1.1 1e-96 323.2 1.1 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 ETO04869.1 - 2.7e-39 134.5 7.8 3.2e-32 111.5 0.1 5.6 4 1 1 5 5 5 4 P-loop containing dynein motor region Dynein_AAA_lid PF17852.1 ETO04869.1 - 1.7e-31 109.0 1.2 1.7e-31 109.0 1.2 3.3 3 1 1 4 4 4 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 ETO04869.1 - 4.4e-20 71.8 0.5 2.1e-19 69.6 0.1 2.5 3 0 0 3 3 2 1 AAA+ lid domain AAA_5 PF07728.14 ETO04869.1 - 7.9e-15 55.1 0.9 0.00027 20.9 0.0 5.7 6 0 0 6 6 6 3 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO04869.1 - 2.1e-05 24.9 1.6 0.063 13.7 0.0 4.5 4 0 0 4 4 4 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETO04869.1 - 0.0045 16.7 0.5 0.36 10.5 0.3 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO04869.1 - 0.012 16.0 5.9 3.5 8.0 0.0 5.2 5 1 0 5 5 5 0 AAA ATPase domain T2SSE PF00437.20 ETO04869.1 - 0.046 12.8 0.9 0.17 10.9 0.1 2.4 3 0 0 3 3 3 0 Type II/IV secretion system protein RNA_helicase PF00910.22 ETO04869.1 - 0.1 13.0 6.1 7.4 7.0 0.1 5.0 6 0 0 6 6 6 0 RNA helicase AAA_19 PF13245.6 ETO04869.1 - 0.12 12.7 0.2 25 5.2 0.1 2.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO04869.1 - 0.13 12.5 13.5 0.85 9.9 0.0 5.4 5 2 1 6 6 6 0 AAA domain DHC_N2 PF08393.13 ETO04870.1 - 8.3e-57 193.1 6.8 8.3e-57 193.1 6.8 3.6 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 2 SieB PF14163.6 ETO04870.1 - 0.03 13.8 0.1 0.09 12.3 0.1 1.8 1 0 0 1 1 1 0 Super-infection exclusion protein B GCIP PF13324.6 ETO04870.1 - 0.064 12.8 6.4 7.3 6.1 0.4 3.6 3 1 0 3 3 3 0 Grap2 and cyclin-D-interacting Spectrin_like PF18373.1 ETO04870.1 - 0.14 12.2 4.8 0.36 10.9 3.5 2.5 2 0 0 2 2 2 0 Spectrin like domain WD40 PF00400.32 ETO04871.1 - 7.1e-60 197.6 11.1 1.4e-10 41.6 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04871.1 - 3.7e-20 72.0 0.2 0.027 14.7 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04871.1 - 9.7e-20 70.8 1.0 0.0066 15.4 0.0 6.8 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO04871.1 - 1.8e-12 47.5 0.1 0.0022 17.9 0.0 4.1 1 1 4 5 5 5 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO04871.1 - 2e-11 43.5 3.6 0.37 10.8 0.0 7.2 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO04871.1 - 6.3e-07 29.0 0.7 0.054 12.8 0.1 3.2 2 1 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO04871.1 - 5.2e-06 25.2 0.0 0.0076 14.8 0.0 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO04871.1 - 0.00014 20.7 1.1 0.27 9.8 0.0 3.9 1 1 1 4 4 4 1 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO04871.1 - 0.00026 19.9 4.2 0.0033 16.2 4.2 3.0 1 1 0 1 1 1 1 Nup133 N terminal like Nbas_N PF15492.6 ETO04871.1 - 0.026 13.8 0.3 3.3 6.9 0.0 3.9 2 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO04871.1 - 0.072 12.1 0.1 1.4 7.9 0.0 2.6 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain HP0268 PF18618.1 ETO04871.1 - 0.092 13.2 0.1 0.28 11.7 0.1 1.8 1 0 0 1 1 1 0 HP0268 Merozoite_SPAM PF07133.11 ETO04872.1 - 0.011 15.8 6.4 0.011 15.8 6.4 1.4 1 1 0 1 1 1 0 Merozoite surface protein (SPAM) WD40 PF00400.32 ETO04873.1 - 4.7e-08 33.6 1.9 0.073 14.0 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04873.1 - 0.012 15.9 0.0 5.5 7.4 0.0 2.4 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04873.1 - 0.074 11.7 0.0 3.4 6.2 0.0 2.0 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Rhamno_transf PF11316.8 ETO04875.1 - 0.03 13.7 0.1 0.033 13.6 0.1 1.1 1 0 0 1 1 1 0 Putative rhamnosyl transferase DUF3450 PF11932.8 ETO04875.1 - 0.098 11.9 9.7 0.11 11.8 9.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Phage_GP20 PF06810.11 ETO04875.1 - 0.12 12.2 12.9 0.13 12.0 12.9 1.1 1 0 0 1 1 1 0 Phage minor structural protein GP20 CENP-Q PF13094.6 ETO04875.1 - 0.3 11.3 12.7 0.43 10.8 12.7 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit GrpE PF01025.19 ETO04875.1 - 0.32 10.6 13.9 0.37 10.5 13.9 1.1 1 0 0 1 1 1 0 GrpE Adhesin_P1_N PF18652.1 ETO04875.1 - 0.44 10.6 9.0 0.35 10.9 5.6 2.1 1 1 1 2 2 2 0 Adhesin P1 N-terminal domain AcylCoA_dehyd_C PF12186.8 ETO04875.1 - 0.51 10.5 5.9 0.64 10.2 5.9 1.3 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal PilO PF04350.13 ETO04875.1 - 0.76 9.9 8.7 0.53 10.4 7.4 1.4 1 1 0 1 1 1 0 Pilus assembly protein, PilO TMPIT PF07851.13 ETO04875.1 - 0.83 8.8 9.6 0.88 8.8 9.6 1.0 1 0 0 1 1 1 0 TMPIT-like protein HAUS6_N PF14661.6 ETO04875.1 - 1.2 8.7 9.6 1.3 8.6 9.6 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Endonuc_Holl PF10107.9 ETO04875.1 - 1.3 8.9 8.8 1.4 8.8 8.8 1.1 1 0 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Mt_ATP-synt_D PF05873.12 ETO04875.1 - 1.3 8.8 11.9 1.8 8.4 11.9 1.4 1 1 0 1 1 1 0 ATP synthase D chain, mitochondrial (ATP5H) Exonuc_VII_L PF02601.15 ETO04875.1 - 1.6 8.2 7.5 1.6 8.3 7.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 ETO04875.1 - 1.8 8.9 16.6 2 8.8 16.6 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF883 PF05957.13 ETO04875.1 - 1.8 9.2 5.2 2.9 8.6 5.2 1.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) GBP_C PF02841.14 ETO04875.1 - 1.8 7.9 16.9 2 7.8 16.9 1.0 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain DUF4407 PF14362.6 ETO04875.1 - 2.4 7.5 7.5 2.5 7.4 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc24 PF08286.11 ETO04875.1 - 3.1 8.1 11.6 3.9 7.8 11.6 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 PIEZO PF15917.5 ETO04875.1 - 3.8 6.9 12.2 4.1 6.8 12.2 1.0 1 0 0 1 1 1 0 Piezo CENP-H PF05837.12 ETO04875.1 - 3.9 7.9 13.2 4.3 7.8 13.2 1.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FYVE_2 PF02318.16 ETO04875.1 - 4 7.7 9.0 4.4 7.6 9.0 1.1 1 0 0 1 1 1 0 FYVE-type zinc finger UPF0242 PF06785.11 ETO04875.1 - 4 7.5 14.9 4.4 7.4 14.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Med21 PF11221.8 ETO04875.1 - 4.2 7.6 13.7 4.6 7.5 13.1 1.4 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF3987 PF13148.6 ETO04875.1 - 5.5 5.9 8.6 5.5 5.9 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) PspB PF06667.12 ETO04875.1 - 5.6 7.1 7.3 4.8 7.3 5.2 1.9 1 1 1 2 2 2 0 Phage shock protein B FemAB PF02388.16 ETO04875.1 - 6.8 5.5 12.3 7.3 5.3 12.3 1.0 1 0 0 1 1 1 0 FemAB family YtxH PF12732.7 ETO04875.1 - 6.9 7.3 8.3 9.7 6.8 8.3 1.5 1 1 0 1 1 1 0 YtxH-like protein YabA PF06156.13 ETO04875.1 - 7.1 7.3 12.7 8.3 7.1 12.7 1.1 1 0 0 1 1 1 0 Initiation control protein YabA FapA PF03961.13 ETO04875.1 - 7.2 5.1 12.0 7.2 5.1 12.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 ETO04875.1 - 7.9 5.3 8.3 8.6 5.1 8.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein MCU PF04678.13 ETO04875.1 - 8 6.5 9.5 11 6.0 9.5 1.4 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF4337 PF14235.6 ETO04875.1 - 8.2 6.5 9.8 8.2 6.5 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF740 PF05340.12 ETO04875.1 - 9.3 4.9 9.7 9.8 4.8 9.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF740) FliJ PF02050.16 ETO04876.1 - 0.012 15.8 1.2 0.022 14.9 1.2 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein Mvb12 PF09452.10 ETO04876.1 - 0.015 15.7 0.5 3.2 8.3 0.2 2.4 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 OmpH PF03938.14 ETO04876.1 - 0.021 15.2 2.8 0.033 14.5 2.8 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) WDCP PF15390.6 ETO04876.1 - 0.091 11.1 2.1 0.1 10.9 2.1 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family CENP-Q PF13094.6 ETO04876.1 - 0.21 11.8 6.1 0.039 14.2 1.8 1.9 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF4825 PF16107.5 ETO04877.1 - 0.032 14.4 2.9 1.1 9.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4825) CDH1_2_SANT_HL1 PF18375.1 ETO04877.1 - 0.039 14.6 0.2 0.039 14.6 0.2 2.4 2 1 0 2 2 2 0 CDH1/2 SANT-Helical linker 1 AAA_24 PF13479.6 ETO04877.1 - 0.7 9.6 5.7 0.58 9.8 0.4 2.7 2 1 1 3 3 3 0 AAA domain AbiH PF14253.6 ETO04877.1 - 1.3 8.8 7.8 0.66 9.8 5.5 1.7 1 1 1 2 2 2 0 Bacteriophage abortive infection AbiH Pannexin_like PF12534.8 ETO04882.1 - 0.017 14.2 1.1 0.024 13.7 1.1 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Helicase_C PF00271.31 ETO04884.1 - 4e-12 46.5 4.9 7.3e-12 45.6 0.0 2.9 3 1 1 4 4 4 1 Helicase conserved C-terminal domain Rop PF01815.16 ETO04885.1 - 0.018 14.9 0.1 0.044 13.7 0.1 1.7 1 0 0 1 1 1 0 Rop protein R3H PF01424.22 ETO04885.1 - 0.11 12.5 0.4 2.7 8.1 0.1 2.4 1 1 1 2 2 2 0 R3H domain WD40 PF00400.32 ETO04887.1 - 0.0065 17.3 3.1 0.0093 16.8 0.7 2.4 3 0 0 3 3 3 1 WD domain, G-beta repeat Kelch_6 PF13964.6 ETO04889.1 - 2.8e-05 24.2 0.1 0.015 15.6 0.0 2.2 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO04889.1 - 0.00012 22.0 0.0 0.0012 18.8 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO04889.1 - 0.013 15.1 0.1 0.45 10.1 0.1 2.2 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO04890.1 - 8.9e-07 29.5 3.0 1.8e-06 28.5 3.0 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat DUF4838 PF16126.5 ETO04890.1 - 0.0032 16.9 1.8 0.0042 16.5 1.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4838) DUF1874 PF08960.10 ETO04893.1 - 0.023 14.8 1.0 0.06 13.5 0.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1874) WD40 PF00400.32 ETO04894.1 - 8e-13 48.7 1.3 0.00021 22.0 0.3 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04894.1 - 0.0029 17.8 0.1 3.5 8.0 0.0 2.8 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04894.1 - 0.0085 14.8 0.5 0.44 9.1 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO04894.1 - 0.014 15.5 0.6 0.055 13.5 0.5 1.9 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region NAC PF01849.18 ETO04895.1 - 2e-13 50.1 4.7 3.4e-11 42.9 0.6 2.6 2 0 0 2 2 2 2 NAC domain FAP PF07174.11 ETO04895.1 - 0.00012 21.7 1.4 0.00016 21.2 1.4 1.1 1 0 0 1 1 1 1 Fibronectin-attachment protein (FAP) RNA_pol_Rpc4 PF05132.14 ETO04895.1 - 0.54 10.7 5.0 0.14 12.6 0.9 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF4834 PF16118.5 ETO04895.1 - 2.8 9.0 8.2 0.52 11.3 0.1 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) FSA_C PF10479.9 ETO04895.1 - 3.3 5.7 7.5 4.3 5.3 7.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Spidroin_MaSp PF11260.8 ETO04898.1 - 0.046 14.0 0.0 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 Major ampullate spidroin 1 and 2 Lipase PF00151.19 ETO04899.1 - 0.2 10.9 3.7 0.23 10.7 3.7 1.1 1 0 0 1 1 1 0 Lipase DUF3464 PF11947.8 ETO04899.1 - 1.9 8.2 5.2 2.5 7.8 5.2 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF4446 PF14584.6 ETO04899.1 - 5.4 7.0 12.3 8.2 6.4 12.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) WD40 PF00400.32 ETO04900.1 - 2.9e-12 46.9 8.1 0.014 16.2 0.2 5.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04900.1 - 1.2e-06 28.8 0.3 0.11 12.8 0.1 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO04900.1 - 0.0002 20.2 2.4 1.2 7.7 0.0 3.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Peptidase_C14 PF00656.22 ETO04902.1 - 4.8e-10 39.8 0.4 8.2e-10 39.1 0.4 1.3 1 0 0 1 1 1 1 Caspase domain F-actin_cap_A PF01267.17 ETO04904.1 - 0.0018 17.7 3.9 0.0023 17.4 3.9 1.2 1 0 0 1 1 1 1 F-actin capping protein alpha subunit FlaG PF03646.15 ETO04905.1 - 0.44 10.8 6.6 0.37 11.0 0.1 2.3 1 1 1 2 2 2 0 FlaG protein HMG14_17 PF01101.18 ETO04908.1 - 0.17 12.9 0.2 0.17 12.9 0.2 2.3 2 0 0 2 2 2 0 HMG14 and HMG17 Tubulin PF00091.25 ETO04910.1 - 3.4e-23 82.9 0.0 4.1e-23 82.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO04910.1 - 0.015 14.5 0.0 0.017 14.4 0.0 1.1 1 0 0 1 1 1 0 Tubulin like CKS PF01111.19 ETO04910.1 - 0.03 14.6 0.2 1.1 9.6 0.2 2.5 2 1 1 3 3 3 0 Cyclin-dependent kinase regulatory subunit DEAD PF00270.29 ETO04911.1 - 2e-18 66.8 0.0 2.4e-18 66.5 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO04911.1 - 1e-05 25.6 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SecA_DEAD PF07517.14 ETO04911.1 - 0.049 12.9 0.0 0.068 12.5 0.0 1.2 1 0 0 1 1 1 0 SecA DEAD-like domain AAA_19 PF13245.6 ETO04911.1 - 0.067 13.5 0.0 0.074 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 ETO04911.1 - 0.17 11.8 0.0 2.8 7.9 0.0 2.1 2 0 0 2 2 2 0 Flavivirus DEAD domain Tubulin_C PF03953.17 ETO04913.1 - 8.1e-36 123.0 0.0 1.2e-35 122.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain GYF_2 PF14237.6 ETO04916.1 - 3.5e-05 23.5 1.9 5.1e-05 23.0 0.2 2.3 3 1 0 3 3 3 1 GYF domain 2 Kelch_1 PF01344.25 ETO04916.1 - 0.014 14.9 2.4 0.017 14.7 0.7 2.0 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO04916.1 - 0.048 13.7 0.7 0.11 12.5 0.7 1.6 1 0 0 1 1 1 0 Galactose oxidase, central domain Cnl2_NKP2 PF09447.10 ETO04916.1 - 0.13 12.5 0.5 0.35 11.0 0.1 2.0 2 0 0 2 2 2 0 Cnl2/NKP2 family protein Striatin PF08232.12 ETO04916.1 - 3.4 8.3 11.5 0.46 11.1 7.6 1.5 2 0 0 2 2 2 0 Striatin family DUF2451 PF10474.9 ETO04918.1 - 4e-33 115.2 0.4 5.6e-33 114.7 0.4 1.2 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) zf-TRAF PF02176.18 ETO04919.1 - 1.2e-07 32.3 2.5 1.2e-07 32.3 2.5 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger YabA PF06156.13 ETO04919.1 - 0.007 17.0 1.1 0.018 15.7 1.1 1.7 1 0 0 1 1 1 1 Initiation control protein YabA Hexapep_2 PF14602.6 ETO04919.1 - 0.18 11.5 0.0 0.37 10.6 0.0 1.5 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase Paz_1 PF18349.1 ETO04920.1 - 0.01 15.8 0.6 0.017 15.0 0.6 1.3 1 0 0 1 1 1 0 PAZ domain Pkinase PF00069.25 ETO04921.1 - 2.3e-08 33.8 0.0 4.9e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO04921.1 - 3e-06 26.7 0.0 9.4e-06 25.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase CAP_GLY PF01302.25 ETO04922.1 - 2.1e-09 37.3 0.7 0.00021 21.2 0.1 2.1 2 0 0 2 2 2 2 CAP-Gly domain DUF4176 PF13780.6 ETO04922.1 - 0.16 12.1 0.1 0.29 11.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) TIM21 PF08294.11 ETO04923.1 - 0.0054 16.6 0.0 0.0071 16.2 0.0 1.2 1 0 0 1 1 1 1 TIM21 RPAP1_C PF08620.10 ETO04924.1 - 2.4e-19 69.2 0.3 2.4e-19 69.2 0.3 2.3 2 0 0 2 2 2 1 RPAP1-like, C-terminal RPAP1_N PF08621.10 ETO04924.1 - 1e-12 47.6 0.2 3.5e-12 45.9 0.2 2.0 1 0 0 1 1 1 1 RPAP1-like, N-terminal DUF4054 PF13262.6 ETO04924.1 - 0.058 13.4 0.8 0.2 11.7 0.8 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4054) BetaGal_dom3 PF13363.6 ETO04924.1 - 0.074 12.6 0.1 0.78 9.4 0.0 2.6 2 0 0 2 2 2 0 Beta-galactosidase, domain 3 DUF1685 PF07939.11 ETO04924.1 - 0.81 9.5 3.0 8.1 6.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1685) WD40 PF00400.32 ETO04925.1 - 6.7e-12 45.7 3.2 9.7e-08 32.6 0.1 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04925.1 - 0.00012 20.9 0.4 0.11 11.1 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO04925.1 - 0.00062 20.0 0.0 0.089 13.1 0.0 2.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Reo_P9 PF06043.11 ETO04927.1 - 0.33 10.3 0.0 0.33 10.3 0.0 2.3 2 0 0 2 2 2 0 Reovirus P9-like family DUF1387 PF07139.11 ETO04928.1 - 1.5 8.5 28.6 1.8 8.3 28.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) TFIIF_alpha PF05793.12 ETO04928.1 - 8.5 4.8 34.4 11 4.5 34.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) ABC2_membrane PF01061.24 ETO04929.1 - 2.8e-15 56.3 16.5 2.8e-15 56.3 16.5 1.6 2 0 0 2 2 2 1 ABC-2 type transporter DUF1634 PF07843.11 ETO04929.1 - 1.8 8.7 10.4 7 6.8 4.7 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1634) Sugar_tr PF00083.24 ETO04933.1 - 1.6e-56 192.1 1.2 2.5e-56 191.4 1.2 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETO04933.1 - 5e-16 58.6 36.8 1.5e-10 40.6 14.8 1.4 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF1624 PF07786.12 ETO04933.1 - 0.34 10.4 9.1 0.63 9.6 9.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1624) ATPgrasp_Ter PF15632.6 ETO04934.1 - 0.047 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon DRTGG PF07085.12 ETO04934.1 - 0.073 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 DRTGG domain CENP-B_dimeris PF09026.10 ETO04935.1 - 0.031 14.7 3.5 3.8 8.0 0.1 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Connexin PF00029.19 ETO04935.1 - 0.064 13.0 4.2 0.13 12.0 4.2 1.5 1 0 0 1 1 1 0 Connexin DUF3384 PF11864.8 ETO04935.1 - 0.096 11.6 4.5 0.29 10.0 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3384) PEX11 PF05648.14 ETO04935.1 - 0.1 12.1 2.8 0.2 11.1 2.8 1.4 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) CM_1 PF07736.11 ETO04935.1 - 0.14 12.6 0.7 0.37 11.2 0.7 1.6 1 0 0 1 1 1 0 Chorismate mutase type I Peptidase_S30 PF01577.16 ETO04935.1 - 0.25 10.9 9.8 0.39 10.3 9.8 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease DUF2235 PF09994.9 ETO04935.1 - 0.26 10.6 3.1 0.42 9.9 3.1 1.3 1 0 0 1 1 1 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) FAM176 PF14851.6 ETO04935.1 - 0.62 9.7 11.0 2.6 7.7 5.3 2.3 2 0 0 2 2 2 0 FAM176 family EIIBC-GUT_N PF03612.14 ETO04935.1 - 0.75 9.5 4.5 1.4 8.7 4.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RP-C_C PF11800.8 ETO04935.1 - 0.87 9.6 4.5 0.89 9.6 2.4 2.0 2 0 0 2 2 2 0 Replication protein C C-terminal region UvrD-helicase PF00580.21 ETO04935.1 - 1.3 8.5 15.9 2 7.9 15.9 1.5 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain Med19 PF10278.9 ETO04935.1 - 1.9 8.4 15.1 3.4 7.6 15.1 1.4 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 DUF3464 PF11947.8 ETO04935.1 - 3.2 7.5 8.3 6 6.6 8.3 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2956 PF11169.8 ETO04935.1 - 3.2 8.0 10.4 7.7 6.8 10.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Vfa1 PF08432.10 ETO04935.1 - 8.5 6.7 19.6 0.18 12.1 11.2 2.1 2 1 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SieB PF14163.6 ETO04936.1 - 4.7 6.7 11.0 7.3 6.1 0.0 4.3 4 1 1 5 5 5 0 Super-infection exclusion protein B RVT_1 PF00078.27 ETO04938.1 - 6e-11 42.3 0.0 7e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SR-25 PF10500.9 ETO04940.1 - 0.0041 16.8 40.7 0.0041 16.8 40.7 3.6 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein fn3 PF00041.21 ETO04940.1 - 0.007 16.7 0.0 3 8.3 0.0 2.7 2 0 0 2 2 2 2 Fibronectin type III domain SAM_KSR1 PF13543.6 ETO04941.1 - 0.16 12.1 0.1 0.25 11.5 0.1 1.3 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 SAM_1 PF00536.30 ETO04941.1 - 0.16 12.4 0.0 0.26 11.7 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO04942.1 - 4.9e-110 356.3 51.5 7.7e-08 32.9 0.0 15.1 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04942.1 - 4.4e-26 91.0 12.8 0.00034 20.9 0.0 10.5 1 1 11 12 12 12 11 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO04942.1 - 1.5e-15 57.3 14.6 0.00036 20.0 0.2 5.8 3 2 1 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 ETO04942.1 - 4.5e-14 52.1 7.5 0.0023 17.0 0.0 8.3 3 3 5 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO04942.1 - 1.3e-07 31.3 12.6 1.1 9.2 0.0 8.7 10 0 0 10 10 10 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO04942.1 - 2.1e-07 30.0 26.1 2 6.9 1.0 10.5 2 2 6 11 11 11 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO04942.1 - 1.4e-05 23.8 5.9 0.47 8.9 0.0 4.8 4 1 0 5 5 5 2 Cytochrome D1 heme domain Str_synth PF03088.16 ETO04942.1 - 0.00015 21.8 1.0 1.6 8.9 0.0 5.9 5 3 2 7 7 7 1 Strictosidine synthase Mid2 PF04478.12 ETO04942.1 - 0.00019 21.3 1.7 7.1 6.4 0.0 5.3 3 1 1 4 4 4 1 Mid2 like cell wall stress sensor IKI3 PF04762.12 ETO04942.1 - 0.0027 15.8 3.1 4 5.3 0.1 4.4 3 1 1 4 4 4 2 IKI3 family VID27 PF08553.10 ETO04942.1 - 0.044 12.8 0.2 0.32 10.0 0.0 2.5 3 1 0 3 3 3 0 VID27 C-terminal WD40-like domain Top6b_C PF18000.1 ETO04942.1 - 0.19 11.9 1.0 24 5.1 0.1 3.6 3 1 1 4 4 4 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain Ricin_B_lectin PF00652.22 ETO04942.1 - 0.63 10.3 11.7 1.3 9.3 0.8 5.5 3 3 4 7 7 7 0 Ricin-type beta-trefoil lectin domain Peptidase_C14 PF00656.22 ETO04943.1 - 3e-05 24.1 1.5 0.0028 17.6 1.5 2.2 1 1 0 1 1 1 1 Caspase domain TetR_C_19 PF17924.1 ETO04943.1 - 1.3 9.6 8.7 2.2 8.9 0.1 2.8 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain zf-RanBP PF00641.18 ETO04944.1 - 0.0074 15.6 2.9 0.0074 15.6 2.9 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others PUB PF09409.10 ETO04945.1 - 0.022 14.7 0.0 0.056 13.4 0.0 1.8 1 1 0 1 1 1 0 PUB domain TPR_12 PF13424.6 ETO04946.1 - 9.7e-19 67.4 0.6 1.1e-06 28.8 0.0 4.2 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO04946.1 - 2.4e-14 52.2 3.7 1.3e-06 28.0 0.1 4.8 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04946.1 - 1.3e-13 50.1 16.2 8.8e-08 31.7 1.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO04946.1 - 2.5e-12 46.2 0.1 2.6e-05 23.9 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04946.1 - 9.8e-10 37.8 5.9 0.0013 18.7 0.3 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04946.1 - 1.2e-09 37.6 21.5 5e-06 26.3 1.5 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO04946.1 - 6.7e-05 23.0 4.3 0.047 14.1 0.0 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO04946.1 - 0.0053 17.5 0.0 8.5 7.5 0.0 2.8 2 1 0 2 2 2 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO04946.1 - 0.011 15.5 2.7 0.2 11.5 0.3 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF5113) Frataxin_Cyay PF01491.16 ETO04946.1 - 0.018 15.1 0.4 0.66 10.1 0.1 2.8 1 1 2 3 3 3 0 Frataxin-like domain MIT PF04212.18 ETO04946.1 - 0.049 13.7 4.3 1.1 9.4 0.4 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO04946.1 - 0.053 13.0 0.5 8 6.0 0.0 3.1 3 0 0 3 3 3 0 SHNi-TPR TPR_11 PF13414.6 ETO04946.1 - 0.29 10.8 14.7 1.3 8.8 0.3 4.6 3 1 1 4 4 4 0 TPR repeat HTH_Bact PF18768.1 ETO04946.1 - 0.43 10.2 6.8 9.4 5.9 1.4 3.9 2 2 1 3 3 3 0 Helix-turn-helix bacterial domain PG_binding_4 PF12229.8 ETO04946.1 - 0.88 9.9 5.5 0.55 10.5 1.0 2.3 1 1 2 3 3 3 0 Putative peptidoglycan binding domain Sel1 PF08238.12 ETO04946.1 - 5.9 7.7 6.1 18 6.2 0.1 3.7 3 1 0 3 3 3 0 Sel1 repeat DUF3439 PF11921.8 ETO04948.1 - 6.5e-05 22.9 5.0 6.5e-05 22.9 5.0 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO04948.1 - 0.00097 17.5 4.8 0.0012 17.2 4.8 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 CAC1F_C PF16885.5 ETO04948.1 - 2.9 7.4 13.2 3.6 7.1 13.2 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Mucin PF01456.17 ETO04948.1 - 4 7.4 23.3 0.36 10.8 17.2 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein GTP_EFTU PF00009.27 ETO04950.1 - 0.0067 16.0 3.2 0.02 14.4 3.2 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Inositol_P PF00459.25 ETO04951.1 - 7.6e-26 91.2 1.3 1.2e-24 87.3 0.0 2.9 3 1 2 5 5 5 1 Inositol monophosphatase family TERB2 PF15101.6 ETO04951.1 - 0.013 15.6 5.0 0.022 14.8 5.0 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Sec62 PF03839.16 ETO04951.1 - 0.036 13.6 3.7 0.058 12.9 3.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Spt20 PF12090.8 ETO04951.1 - 0.062 12.9 13.2 0.11 12.1 13.2 1.3 1 0 0 1 1 1 0 Spt20 family Ctr PF04145.15 ETO04951.1 - 0.13 12.9 0.4 0.22 12.2 0.4 1.5 1 0 0 1 1 1 0 Ctr copper transporter family FAM76 PF16046.5 ETO04951.1 - 0.17 11.2 11.3 0.3 10.4 11.3 1.3 1 0 0 1 1 1 0 FAM76 protein DUF5524 PF17662.1 ETO04951.1 - 0.18 11.2 7.7 0.28 10.5 7.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5524) MPM1 PF17234.2 ETO04951.1 - 0.24 11.6 9.2 0.46 10.7 9.2 1.4 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 TMEM51 PF15345.6 ETO04951.1 - 0.26 11.1 8.8 0.44 10.4 8.8 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 CDC45 PF02724.14 ETO04951.1 - 0.34 9.1 10.8 0.48 8.6 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.10 ETO04951.1 - 0.36 9.5 3.6 0.47 9.1 3.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAS20 PF02064.15 ETO04951.1 - 0.36 10.9 7.2 0.62 10.2 7.2 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor ALMT PF11744.8 ETO04951.1 - 0.41 9.4 4.4 0.59 8.9 4.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2828 PF11443.8 ETO04951.1 - 0.43 8.6 8.0 0.6 8.1 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peptidase_S30 PF01577.16 ETO04951.1 - 0.86 9.2 11.6 1.4 8.4 11.6 1.2 1 0 0 1 1 1 0 Potyvirus P1 protease Nucleoside_tran PF01733.18 ETO04951.1 - 0.88 8.9 2.4 0.79 9.1 1.0 1.5 2 0 0 2 2 2 0 Nucleoside transporter RR_TM4-6 PF06459.12 ETO04951.1 - 0.92 9.3 10.5 1.4 8.6 10.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 ETO04951.1 - 1.2 8.8 6.7 13 5.4 6.4 2.3 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.5 ETO04951.1 - 1.3 10.0 8.7 4.4 8.3 8.7 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CobT PF06213.12 ETO04951.1 - 1.3 8.3 13.9 2.2 7.6 13.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CLN3 PF02487.17 ETO04951.1 - 1.7 7.6 3.2 2.5 7.0 3.2 1.2 1 0 0 1 1 1 0 CLN3 protein Mit_KHE1 PF10173.9 ETO04951.1 - 1.8 8.6 6.3 3.2 7.8 6.3 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Membralin PF09746.9 ETO04951.1 - 2.8 6.9 5.2 4.4 6.3 5.2 1.2 1 0 0 1 1 1 0 Tumour-associated protein Hid1 PF12722.7 ETO04951.1 - 3.9 5.5 9.7 5.3 5.0 9.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO04951.1 - 4 6.1 12.5 6.3 5.5 12.5 1.2 1 0 0 1 1 1 0 Presenilin EF-hand_1 PF00036.32 ETO04952.1 - 3.4e-06 26.2 0.0 0.008 15.7 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO04952.1 - 1.2e-05 25.7 0.3 3.2e-05 24.3 0.3 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO04952.1 - 9.2e-05 22.1 0.1 0.59 10.2 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO04952.1 - 0.0047 16.7 0.6 1.8 8.5 0.0 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO04952.1 - 0.0072 15.8 0.1 2.4 7.8 0.0 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 ETO04952.1 - 0.054 13.8 3.2 0.22 11.9 3.2 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region Vps16_C PF04840.12 ETO04953.1 - 0.0075 15.3 0.1 0.0087 15.1 0.1 1.1 1 0 0 1 1 1 1 Vps16, C-terminal region Tai4 PF16695.5 ETO04953.1 - 0.0095 16.4 0.1 0.014 15.9 0.1 1.2 1 0 0 1 1 1 1 Type VI secretion system (T6SS), amidase immunity protein DUF3475 PF11961.8 ETO04953.1 - 0.14 12.3 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3475) DUF4923 PF16270.5 ETO04954.1 - 0.039 13.8 0.7 0.11 12.3 0.3 1.8 1 1 1 2 2 2 0 Lipocalin-like domain (DUF4923) PPR_2 PF13041.6 ETO04954.1 - 0.043 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 PPR repeat family Vac14_Fab1_bd PF12755.7 ETO04954.1 - 0.33 11.6 1.6 6.9 7.3 0.1 2.8 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region DUF2431 PF10354.9 ETO04954.1 - 1.5 9.0 4.3 21 5.4 4.3 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF2431) DUF4298 PF14131.6 ETO04955.1 - 0.0059 16.5 2.3 0.0059 16.5 2.3 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4298) Focal_AT PF03623.13 ETO04955.1 - 0.0076 16.3 0.5 0.0091 16.0 0.5 1.1 1 0 0 1 1 1 1 Focal adhesion targeting region Casc1_N PF15927.5 ETO04955.1 - 0.013 15.2 4.0 0.015 15.0 4.0 1.1 1 0 0 1 1 1 0 Cancer susceptibility candidate 1 N-terminus PAS_6 PF08348.11 ETO04955.1 - 0.019 14.8 0.5 0.022 14.6 0.5 1.1 1 0 0 1 1 1 0 YheO-like PAS domain Lge1 PF11488.8 ETO04955.1 - 0.026 14.7 3.4 0.026 14.7 3.4 1.6 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 GldM_N PF12081.8 ETO04955.1 - 0.033 14.3 6.6 0.04 14.0 6.6 1.0 1 0 0 1 1 1 0 GldM N-terminal domain COMM_domain PF07258.14 ETO04955.1 - 0.038 14.1 0.4 0.093 12.9 0.2 1.7 1 1 0 1 1 1 0 COMM domain Mur_ligase_M PF08245.12 ETO04955.1 - 0.046 13.7 2.7 0.05 13.6 2.7 1.0 1 0 0 1 1 1 0 Mur ligase middle domain DUF16 PF01519.16 ETO04955.1 - 0.078 13.5 7.4 0.11 13.1 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 Methyltransf_9 PF08003.11 ETO04955.1 - 0.11 11.4 1.1 0.11 11.4 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) GTP_EFTU PF00009.27 ETO04955.1 - 0.12 11.9 4.1 0.25 10.8 4.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain CortBP2 PF09727.9 ETO04955.1 - 0.14 12.1 4.4 0.15 11.9 4.4 1.0 1 0 0 1 1 1 0 Cortactin-binding protein-2 NBD94 PF16830.5 ETO04955.1 - 0.14 12.6 11.5 1.1 9.7 11.5 2.0 1 1 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH FlaC_arch PF05377.11 ETO04955.1 - 0.25 11.8 6.3 0.23 11.9 0.8 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Phage_Mu_Gam PF07352.12 ETO04955.1 - 0.28 11.1 7.1 0.068 13.1 3.1 1.8 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein DHR10 PF18595.1 ETO04955.1 - 1.2 9.2 5.3 0.32 11.1 1.9 1.6 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain DUF3439 PF11921.8 ETO04956.1 - 4.6 7.2 8.8 1.9 8.5 2.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Lzipper-MIP1 PF14389.6 ETO04958.1 - 0.18 12.2 7.8 1.3 9.4 7.0 2.6 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 ApoO PF09769.9 ETO04958.1 - 0.23 11.4 6.7 1.8 8.6 1.9 2.5 2 1 1 3 3 3 0 Apolipoprotein O Hormone_1 PF00103.20 ETO04958.1 - 1.2 8.8 10.9 0.045 13.5 4.8 1.7 2 0 0 2 2 2 0 Somatotropin hormone family DUF1664 PF07889.12 ETO04958.1 - 1.3 9.1 11.3 4 7.5 1.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Metallophos PF00149.28 ETO04959.1 - 1.6e-15 58.2 0.0 3.1e-15 57.2 0.0 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO04959.1 - 0.1 13.0 0.0 0.27 11.7 0.0 1.7 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain NTP_transferase PF00483.23 ETO04960.1 - 1.6e-47 162.2 0.0 2.3e-47 161.7 0.0 1.1 1 0 0 1 1 1 1 Nucleotidyl transferase NTP_transf_3 PF12804.7 ETO04960.1 - 3.4e-11 43.8 0.0 4e-11 43.5 0.0 1.1 1 0 0 1 1 1 1 MobA-like NTP transferase domain IspD PF01128.19 ETO04960.1 - 0.0087 15.8 0.0 0.016 15.0 0.0 1.4 2 0 0 2 2 2 1 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase DCP1 PF06058.13 ETO04960.1 - 0.12 12.3 0.1 0.26 11.2 0.1 1.5 2 0 0 2 2 2 0 Dcp1-like decapping family Hexapep PF00132.24 ETO04961.1 - 2.1e-12 46.2 5.5 9.2e-08 31.5 2.1 3.2 1 1 2 3 3 3 2 Bacterial transferase hexapeptide (six repeats) Fucokinase PF07959.12 ETO04961.1 - 0.0051 15.8 0.0 0.0083 15.1 0.0 1.4 1 1 0 1 1 1 1 L-fucokinase DUF4954 PF16314.5 ETO04961.1 - 0.015 13.5 0.2 0.016 13.4 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4954) Hexapep_2 PF14602.6 ETO04961.1 - 0.59 9.9 6.9 0.25 11.1 3.2 2.5 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase TPR_12 PF13424.6 ETO04962.1 - 2.6e-06 27.6 4.8 3.8e-06 27.1 0.3 3.0 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO04962.1 - 1.4e-05 24.8 2.5 0.074 13.2 0.2 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04962.1 - 0.00086 19.3 5.2 0.014 15.6 0.1 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_18 PF13512.6 ETO04962.1 - 0.00089 19.4 0.3 0.016 15.3 0.0 2.2 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04962.1 - 0.0011 18.7 7.0 0.01 15.6 0.3 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat RAMP4 PF06624.12 ETO04962.1 - 0.031 14.3 1.7 10 6.3 0.1 3.1 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 TPR_17 PF13431.6 ETO04962.1 - 0.037 14.4 0.1 3.2 8.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_12 PF08242.12 ETO04962.1 - 0.043 14.6 0.4 0.13 13.0 0.1 2.0 2 0 0 2 2 2 0 Methyltransferase domain Halogen_Hydrol PF10112.9 ETO04962.1 - 3.9 7.4 8.3 3 7.8 0.6 3.0 3 0 0 3 3 3 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein TPR_2 PF07719.17 ETO04963.1 - 5.9e-09 35.4 8.5 0.098 12.8 0.0 5.5 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO04963.1 - 1.5e-08 34.4 6.3 3.7e-05 23.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO04963.1 - 3.1e-08 33.2 4.7 7.1e-05 22.4 0.0 3.1 3 0 0 3 3 3 2 TPR repeat TPR_12 PF13424.6 ETO04963.1 - 5.1e-06 26.7 5.4 0.026 14.8 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO04963.1 - 0.00012 22.0 1.6 24 5.5 0.0 5.0 5 1 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO04963.1 - 0.00079 20.0 0.3 0.86 10.3 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO04963.1 - 0.0011 18.7 11.1 0.34 10.8 0.0 5.5 6 0 0 6 6 6 1 Tetratricopeptide repeat Vta1_C PF18097.1 ETO04963.1 - 0.015 14.9 0.1 0.38 10.5 0.0 2.5 2 0 0 2 2 2 0 Vta1 C-terminal domain TPR_MalT PF17874.1 ETO04963.1 - 0.024 14.0 1.8 0.079 12.3 0.3 2.1 2 0 0 2 2 2 0 MalT-like TPR region TPR_10 PF13374.6 ETO04963.1 - 0.059 13.3 0.4 3.4 7.7 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF410 PF04190.13 ETO04963.1 - 0.094 12.5 7.2 0.098 12.4 0.5 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF410) TPR_14 PF13428.6 ETO04963.1 - 0.13 13.2 0.0 77 4.5 0.0 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat Metallophos PF00149.28 ETO04964.1 - 1.9e-16 61.2 0.0 4.9e-16 59.8 0.0 1.6 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Kelch_5 PF13854.6 ETO04965.1 - 0.014 15.4 0.2 0.22 11.6 0.1 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO04965.1 - 0.16 12.3 0.0 0.36 11.2 0.0 1.6 1 0 0 1 1 1 0 Kelch motif zf-RanBP PF00641.18 ETO04966.1 - 6.3e-06 25.4 7.0 1.6e-05 24.1 7.0 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others C1_2 PF03107.16 ETO04966.1 - 0.016 15.6 2.3 0.043 14.1 2.3 1.7 1 0 0 1 1 1 0 C1 domain HAD_2 PF13419.6 ETO04967.1 - 2.7e-07 30.8 0.0 0.0038 17.3 0.0 2.0 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETO04967.1 - 0.0019 18.5 0.0 0.025 14.9 0.0 2.0 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETO04967.1 - 0.019 15.0 0.0 0.032 14.3 0.0 1.2 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase ADP_ribosyl_GH PF03747.14 ETO04969.1 - 0.0033 17.2 0.1 0.0066 16.2 0.0 1.5 2 0 0 2 2 2 1 ADP-ribosylglycohydrolase Rer1 PF03248.13 ETO04969.1 - 0.019 14.7 0.0 0.033 13.9 0.0 1.4 1 0 0 1 1 1 0 Rer1 family MscL PF01741.18 ETO04969.1 - 0.086 13.1 0.5 0.17 12.2 0.5 1.5 1 0 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL SelK_SelG PF10961.8 ETO04969.1 - 0.12 12.9 0.0 0.27 11.9 0.0 1.5 1 0 0 1 1 1 0 Selenoprotein SelK_SelG CLN3 PF02487.17 ETO04969.1 - 0.14 11.1 0.1 0.18 10.8 0.1 1.1 1 0 0 1 1 1 0 CLN3 protein Afi1 PF07792.12 ETO04969.1 - 0.17 12.4 2.5 0.29 11.6 2.5 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking WD40 PF00400.32 ETO04970.1 - 8.3e-87 282.8 42.9 1.5e-06 28.8 0.0 16.2 15 1 1 16 16 16 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04970.1 - 2.1e-27 95.3 12.1 0.19 12.0 0.1 13.6 1 1 12 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO04970.1 - 2.4e-08 34.1 0.0 4.9e-08 33.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PD40 PF07676.12 ETO04970.1 - 6.7e-08 32.3 15.4 0.45 10.5 0.1 9.3 10 0 0 10 10 9 2 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO04970.1 - 6e-07 29.0 1.6 1.2e-06 28.0 1.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO04970.1 - 0.0003 21.3 0.2 0.0042 17.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO04970.1 - 0.00035 20.8 0.0 0.0014 18.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain Nbas_N PF15492.6 ETO04970.1 - 0.0018 17.6 8.5 1.5 8.1 0.0 6.7 3 2 3 8 8 8 1 Neuroblastoma-amplified sequence, N terminal Pentapeptide_4 PF13599.6 ETO04970.1 - 0.003 17.7 0.1 0.0076 16.4 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO04970.1 - 0.017 15.2 0.1 0.056 13.6 0.1 1.8 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) NB-ARC PF00931.22 ETO04970.1 - 0.046 12.9 3.7 0.039 13.1 0.7 2.4 2 1 0 2 2 2 0 NB-ARC domain RNA_helicase PF00910.22 ETO04970.1 - 0.049 14.0 0.4 0.4 11.1 0.1 3.0 2 1 0 2 2 2 0 RNA helicase ATPase PF06745.13 ETO04970.1 - 0.078 12.3 4.8 1.4 8.2 0.0 3.2 3 1 0 3 3 3 0 KaiC ABC_tran PF00005.27 ETO04970.1 - 0.081 13.4 0.6 0.63 10.6 0.1 2.7 2 0 0 2 2 2 0 ABC transporter TolB_N PF04052.13 ETO04970.1 - 0.1 12.8 3.4 2.1e+02 2.2 0.0 7.0 10 0 0 10 10 10 0 TolB amino-terminal domain PQQ_2 PF13360.6 ETO04970.1 - 0.11 12.1 0.3 6.1 6.3 0.1 2.9 1 1 1 2 2 2 0 PQQ-like domain Secretin_N_2 PF07655.13 ETO04971.1 - 1.4 9.5 14.9 4 8.0 14.9 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Secretin_N_2 PF07655.13 ETO04972.1 - 1.2 9.8 23.2 10 6.7 0.3 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Apt1 PF10351.9 ETO04972.1 - 2.4 6.9 9.6 4.2 6.1 9.6 1.4 1 1 0 1 1 1 0 Golgi-body localisation protein domain SPT_ssu-like PF11779.8 ETO04974.1 - 0.16 11.7 6.3 0.33 10.6 6.3 1.5 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like Peptidase_C14 PF00656.22 ETO04975.1 - 0.00017 21.7 0.5 0.00032 20.7 0.5 1.5 1 1 0 1 1 1 1 Caspase domain WD40 PF00400.32 ETO04976.1 - 4.9e-35 119.0 5.6 2.2e-09 37.8 0.2 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO04976.1 - 1.3e-20 73.5 0.4 0.0017 18.6 0.0 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO04976.1 - 1.3e-09 37.5 0.1 0.048 12.6 0.0 3.9 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO04976.1 - 1.2e-08 34.1 1.4 0.012 14.3 0.0 3.8 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO04976.1 - 3.4e-08 32.4 0.2 0.012 14.2 0.0 3.5 1 1 3 4 4 4 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO04976.1 - 2.5e-07 30.3 0.3 4.5e-05 22.9 0.3 2.5 1 1 2 3 3 3 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO04976.1 - 5.6e-07 29.0 1.3 0.0011 18.2 0.1 1.6 1 1 1 2 2 2 2 Coatomer WD associated region PQQ_2 PF13360.6 ETO04976.1 - 5.7e-05 22.8 0.0 7.8e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 PQQ-like domain DUF5570 PF17731.1 ETO04976.1 - 0.0017 18.4 1.1 2 8.5 0.0 3.4 1 1 3 4 4 4 1 Family of unknown function (DUF5570) DPPIV_N PF00930.21 ETO04976.1 - 0.0034 16.2 0.1 16 4.1 0.0 3.7 2 1 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO04976.1 - 0.0066 16.3 0.0 19 5.4 0.0 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat PD40 PF07676.12 ETO04976.1 - 0.03 14.3 0.0 17 5.5 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO04976.1 - 0.031 13.9 1.2 42 3.9 0.0 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Big_7 PF17957.1 ETO04976.1 - 0.033 14.9 1.8 9.1 7.1 0.1 2.6 1 1 1 2 2 2 0 Bacterial Ig domain Nucleoporin_N PF08801.11 ETO04976.1 - 0.037 12.8 1.4 0.45 9.2 0.3 2.7 1 1 0 2 2 2 0 Nup133 N terminal like Asp_decarbox PF02261.16 ETO04976.1 - 0.069 13.1 0.0 15 5.6 0.0 3.3 3 1 1 4 4 4 0 Aspartate decarboxylase MRJP PF03022.16 ETO04976.1 - 0.072 12.4 0.2 1.4 8.2 0.0 2.5 1 1 2 3 3 3 0 Major royal jelly protein VID27 PF08553.10 ETO04976.1 - 0.1 11.7 0.0 1.2 8.2 0.0 2.1 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain AbrB_C PF18277.1 ETO04976.1 - 0.17 11.5 0.5 2.3 7.9 0.1 2.8 2 1 0 2 2 2 0 AbrB C-terminal domain Kelch_2 PF07646.15 ETO04977.1 - 4.1e-05 23.4 1.7 0.16 12.0 0.1 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO04977.1 - 0.00024 21.3 5.1 0.71 10.3 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO04977.1 - 0.00042 19.8 0.3 1.3 8.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO04977.1 - 0.0051 16.8 3.6 1.2 9.1 0.0 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO04977.1 - 0.031 14.3 0.3 1 9.4 0.0 3.4 5 0 0 5 5 5 0 Galactose oxidase, central domain Cad PF03596.13 ETO04978.1 - 0.04 13.8 2.6 0.33 10.8 2.5 2.0 1 1 0 1 1 1 0 Cadmium resistance transporter Tom22 PF04281.13 ETO04979.1 - 0.023 14.5 0.2 0.038 13.8 0.2 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Acetyltransf_1 PF00583.25 ETO04980.1 - 1.1e-14 54.6 0.0 1.3e-14 54.4 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO04980.1 - 4e-09 36.8 0.1 6.3e-09 36.1 0.1 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO04980.1 - 2.9e-08 33.7 0.1 3.8e-08 33.3 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ETO04980.1 - 0.00018 21.7 0.3 0.00021 21.5 0.3 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO04980.1 - 0.00067 19.6 0.0 0.0018 18.2 0.0 1.6 2 0 0 2 2 2 1 FR47-like protein Acetyltransf_9 PF13527.7 ETO04980.1 - 0.00083 19.4 0.0 0.0011 19.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ETO04980.1 - 0.0028 18.3 0.0 0.0036 18.0 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETO04980.1 - 0.026 14.7 0.1 0.041 14.0 0.1 1.4 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase TetR_C_5 PF08360.11 ETO04980.1 - 0.044 14.0 1.0 5.6 7.1 0.4 2.1 2 0 0 2 2 2 0 QacR-like protein, C-terminal region Acetyltransf_8 PF13523.6 ETO04980.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DUF1659 PF07872.11 ETO04981.1 - 0.047 13.3 6.1 1.9 8.2 0.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1659) zf-TRAF PF02176.18 ETO04982.1 - 0.00015 22.4 3.3 0.00018 22.2 0.2 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger MyTH4 PF00784.17 ETO04982.1 - 0.021 15.3 1.5 0.057 13.9 1.5 1.9 1 1 0 1 1 1 0 MyTH4 domain zf-C3HC4_2 PF13923.6 ETO04982.1 - 0.25 11.2 7.2 1.6 8.7 4.2 3.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-nanos PF05741.13 ETO04982.1 - 0.3 11.4 6.4 6.7 7.0 0.1 3.0 2 1 1 3 3 3 0 Nanos RNA binding domain WD40 PF00400.32 ETO04983.1 - 2.2e-07 31.5 10.1 0.00029 21.6 0.1 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO04983.1 - 0.0057 15.4 0.1 0.067 11.8 0.0 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Kinesin PF00225.23 ETO04986.1 - 7.4e-39 133.6 0.4 1.8e-38 132.3 0.4 1.6 1 0 0 1 1 1 1 Kinesin motor domain Effector_1 PF04518.12 ETO04986.1 - 0.0002 20.6 1.6 0.00041 19.6 1.6 1.4 1 0 0 1 1 1 1 Effector from type III secretion system EF-hand_1 PF00036.32 ETO04986.1 - 0.00075 18.9 0.3 0.0027 17.1 0.3 2.1 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO04986.1 - 0.0027 17.5 0.1 0.014 15.3 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EzrA PF06160.12 ETO04986.1 - 0.0045 15.2 5.3 0.0083 14.4 5.3 1.4 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA EF-hand_7 PF13499.6 ETO04986.1 - 0.017 15.5 0.4 0.079 13.4 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair COG5 PF10392.9 ETO04986.1 - 0.079 13.1 3.9 0.22 11.7 3.9 1.7 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Kinesin_assoc PF16183.5 ETO04986.1 - 0.58 10.3 6.4 2.4 8.2 1.4 3.0 2 1 0 2 2 2 0 Kinesin-associated DUF1664 PF07889.12 ETO04986.1 - 1.6 8.8 6.2 11 6.1 6.2 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HAUS-augmin3 PF14932.6 ETO04986.1 - 8.4 5.9 13.1 0.063 12.8 4.2 2.0 3 0 0 3 3 3 0 HAUS augmin-like complex subunit 3 TMEM208_SND2 PF05620.11 ETO04988.1 - 0.0031 17.3 0.7 0.0031 17.3 0.7 2.8 2 1 1 3 3 3 1 SRP-independent targeting protein 2/TMEM208 Tmemb_9 PF05434.11 ETO04988.1 - 0.024 14.5 0.0 0.024 14.5 0.0 1.5 2 0 0 2 2 2 0 TMEM9 UPF0239 PF06783.11 ETO04988.1 - 0.061 13.5 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Halogen_Hydrol PF10112.9 ETO04988.1 - 0.065 13.3 0.1 0.065 13.3 0.1 2.1 1 1 1 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF4834 PF16118.5 ETO04988.1 - 0.19 12.7 0.1 0.19 12.7 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 ETO04988.1 - 0.8 10.3 0.0 0.8 10.3 0.0 3.0 1 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Herpes_LMP1 PF05297.11 ETO04988.1 - 8.7 5.4 6.4 11 5.2 6.4 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PP1 PF07430.11 ETO04989.1 - 0.049 13.7 0.1 3.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Phloem filament protein PP1 cystatin-like domain DUF1283 PF06932.11 ETO04989.1 - 5.9 7.2 10.5 1 9.6 3.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1283) BLM10_mid PF16507.5 ETO04990.1 - 0.0002 20.2 0.1 0.0014 17.4 0.1 2.2 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF2379 PF09543.10 ETO04991.1 - 0.0057 16.8 0.1 0.0084 16.3 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2379) FIN1 PF17300.2 ETO04991.1 - 0.0067 16.0 5.3 0.0078 15.8 5.3 1.1 1 0 0 1 1 1 1 Filaments in between nuclei protein-1 HSBP1 PF06825.12 ETO04991.1 - 0.027 14.3 1.6 0.07 13.0 1.5 1.7 1 1 0 1 1 1 0 Heat shock factor binding protein 1 DUF1664 PF07889.12 ETO04991.1 - 0.34 10.9 2.0 0.47 10.5 2.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) CH PF00307.31 ETO04992.1 - 4.7e-10 39.6 2.3 4.3e-09 36.5 2.3 2.3 1 1 0 1 1 1 1 Calponin homology (CH) domain Pox_A_type_inc PF04508.12 ETO04992.1 - 0.025 14.4 1.0 0.35 10.8 0.1 2.6 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat CAMSAP_CH PF11971.8 ETO04992.1 - 0.31 10.9 2.5 0.33 10.8 0.1 2.3 2 1 2 4 4 4 0 CAMSAP CH domain FAA_hydrolase PF01557.18 ETO04993.1 - 6e-08 32.6 0.0 6e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family FAA_hydrolase_N PF09298.11 ETO04994.1 - 1.3e-30 105.7 0.0 1.8e-30 105.3 0.0 1.2 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal FAA_hydrolase PF01557.18 ETO04994.1 - 1.1e-14 54.7 0.0 1.8e-14 54.0 0.0 1.3 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family mRNA_cap_enzyme PF01331.19 ETO04995.1 - 2.3e-25 89.6 7.2 1.1e-23 84.1 3.3 2.8 3 0 0 3 3 3 2 mRNA capping enzyme, catalytic domain mRNA_cap_C PF03919.15 ETO04995.1 - 1e-06 29.4 1.8 7.6e-06 26.5 0.1 2.5 2 0 0 2 2 2 1 mRNA capping enzyme, C-terminal domain DNA_ligase_A_M PF01068.21 ETO04995.1 - 8.4e-05 22.3 1.3 0.17 11.5 0.1 2.7 2 1 1 3 3 3 2 ATP dependent DNA ligase domain YwpF PF14183.6 ETO04995.1 - 0.07 13.1 1.7 1.7 8.7 0.3 2.5 1 1 2 3 3 3 0 YwpF-like protein DUF1218 PF06749.12 ETO04997.1 - 0.83 10.2 5.1 1.8 9.2 5.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) Sulfotransfer_2 PF03567.14 ETO04998.1 - 2.8e-08 34.0 0.3 3.5e-08 33.7 0.3 1.3 1 0 0 1 1 1 1 Sulfotransferase family SAM_Exu PF18609.1 ETO04998.1 - 0.37 10.9 2.8 5.4 7.2 0.1 2.4 2 0 0 2 2 2 0 Exuperantia SAM-like domain RhoGEF PF00621.20 ETO04999.1 - 1.1e-14 55.1 1.2 1.4e-14 54.8 1.2 1.1 1 0 0 1 1 1 1 RhoGEF domain AAA_22 PF13401.6 ETO05001.1 - 0.00031 21.0 0.1 0.018 15.3 0.0 3.3 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 ETO05001.1 - 0.0057 16.2 0.1 0.027 14.0 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 ETO05001.1 - 0.087 13.3 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETO05001.1 - 0.2 11.3 0.0 2.6 7.7 0.0 2.5 2 1 0 2 2 2 0 AAA domain Pkinase PF00069.25 ETO05002.1 - 7e-07 28.9 0.1 9.5e-07 28.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05002.1 - 0.0044 16.3 0.0 0.0056 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4598 PF15370.6 ETO05004.1 - 0.014 15.9 7.7 0.014 15.9 7.7 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4598) NACHT PF05729.12 ETO05005.1 - 3.8e-09 36.7 0.2 1.1e-07 32.0 0.2 2.3 1 1 0 1 1 1 1 NACHT domain Mg_chelatase PF01078.21 ETO05005.1 - 0.00016 21.1 0.0 0.0023 17.3 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ETO05005.1 - 0.00078 19.9 0.0 0.0035 17.8 0.0 2.0 3 0 0 3 3 3 1 AAA ATPase domain NB-ARC PF00931.22 ETO05005.1 - 0.001 18.3 1.8 0.0012 18.1 0.2 1.9 1 1 1 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 ETO05005.1 - 0.0076 16.5 0.0 0.03 14.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain SMC_N PF02463.19 ETO05005.1 - 0.01 15.3 0.2 0.095 12.1 0.0 2.1 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 ETO05005.1 - 0.011 15.8 0.6 0.03 14.4 0.1 1.9 1 1 1 2 2 2 0 Helicase HerA, central domain AAA_25 PF13481.6 ETO05005.1 - 0.029 13.9 0.0 0.076 12.6 0.0 1.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO05005.1 - 0.052 13.9 1.8 0.14 12.5 0.1 2.5 2 1 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO05005.1 - 0.1 13.1 0.0 0.27 11.7 0.0 1.8 2 0 0 2 2 2 0 ABC transporter Sigma54_activat PF00158.26 ETO05005.1 - 0.13 12.0 0.0 0.31 10.7 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain WD40 PF00400.32 ETO05006.1 - 2.7e-50 167.3 20.2 6.4e-09 36.3 0.1 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05006.1 - 5.2e-15 55.5 3.2 0.00093 19.5 0.1 6.3 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05006.1 - 6.2e-07 29.0 15.6 0.0014 18.0 0.1 4.7 3 2 2 5 5 5 2 WD40-like domain Kelch_6 PF13964.6 ETO05006.1 - 7.1e-06 26.1 3.3 0.033 14.5 0.0 5.3 5 0 0 5 5 5 1 Kelch motif Cytochrom_D1 PF02239.16 ETO05006.1 - 5.5e-05 21.9 1.5 0.031 12.8 0.0 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain Kelch_4 PF13418.6 ETO05006.1 - 0.0023 17.9 2.6 0.025 14.6 0.1 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO05006.1 - 0.012 15.2 2.7 4.3 7.0 0.0 4.0 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO05006.1 - 0.015 15.6 0.2 0.18 12.1 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO05006.1 - 0.084 12.9 1.9 3.2 7.8 0.2 3.6 4 0 0 4 4 4 0 Kelch motif DUF2072 PF09845.9 ETO05006.1 - 0.48 10.7 7.3 1.3 9.3 7.3 1.7 1 0 0 1 1 1 0 Zn-ribbon containing protein TPR_12 PF13424.6 ETO05007.1 - 1e-161 525.6 62.2 4.4e-18 65.3 0.4 12.9 6 1 8 15 15 15 15 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05007.1 - 1.6e-109 353.7 141.0 5.1e-08 32.4 1.1 22.0 22 0 0 22 22 22 20 Tetratricopeptide repeat TPR_10 PF13374.6 ETO05007.1 - 3.4e-107 347.9 22.2 4.1e-10 39.2 0.1 20.9 22 0 0 22 22 22 16 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05007.1 - 7.7e-93 297.9 43.6 1.2e-07 31.2 0.1 19.7 19 0 0 19 19 19 16 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05007.1 - 2.1e-79 255.3 111.7 2.2e-06 27.3 0.0 21.8 22 0 0 22 22 22 18 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05007.1 - 2.4e-56 183.3 120.1 0.00037 20.5 0.5 21.1 21 0 0 21 21 21 18 Tetratricopeptide repeat TPR_17 PF13431.6 ETO05007.1 - 2e-29 99.8 57.0 0.00068 19.8 0.1 19.2 20 0 0 20 20 19 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO05007.1 - 2.7e-27 94.2 98.3 0.00052 19.6 3.6 22.5 19 4 3 22 22 21 11 TPR repeat TPR_6 PF13174.6 ETO05007.1 - 3.7e-23 80.6 21.8 0.03 15.0 0.0 16.5 19 0 0 19 19 16 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO05007.1 - 1.3e-19 69.2 0.0 0.3 12.0 0.0 12.4 14 0 0 14 14 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO05007.1 - 4.7e-19 68.8 1.2 0.14 12.8 0.0 12.3 12 3 0 12 12 10 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO05007.1 - 3.1e-17 63.0 0.0 8.3e-06 25.4 0.0 5.8 2 1 3 6 6 6 4 MalT-like TPR region TPR_19 PF14559.6 ETO05007.1 - 3e-09 37.3 7.1 1.5 9.3 0.1 8.6 8 3 3 12 12 10 1 Tetratricopeptide repeat PPR PF01535.20 ETO05007.1 - 8.2e-08 32.0 60.7 0.069 13.4 0.1 14.4 16 0 0 16 16 16 6 PPR repeat TPR_3 PF07720.12 ETO05007.1 - 2.7e-06 27.3 91.5 0.03 14.3 0.2 15.3 17 0 0 17 17 16 5 Tetratricopeptide repeat Kelch_6 PF13964.6 ETO05007.1 - 6.7e-05 23.0 4.7 0.92 9.9 0.2 4.1 3 0 0 3 3 3 2 Kelch motif SHNi-TPR PF10516.9 ETO05007.1 - 0.0022 17.4 22.2 1.4 8.4 0.0 10.3 12 0 0 12 12 12 1 SHNi-TPR ANAPC3 PF12895.7 ETO05007.1 - 0.0069 16.6 76.2 0.091 13.0 0.2 13.6 5 5 11 16 16 16 4 Anaphase-promoting complex, cyclosome, subunit 3 bPH_3 PF14470.6 ETO05007.1 - 0.0099 16.2 6.6 15 6.0 0.0 6.8 5 2 3 8 8 8 0 Bacterial PH domain Kelch_3 PF13415.6 ETO05007.1 - 0.014 15.7 0.0 0.043 14.1 0.0 1.9 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO05007.1 - 0.023 14.3 2.8 1.5 8.5 0.9 3.2 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO05007.1 - 0.1 12.6 0.7 1.2 9.2 0.1 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain PRP4 PF08799.11 ETO05007.1 - 0.2 11.2 0.0 41 3.9 0.0 3.3 3 0 0 3 3 3 0 pre-mRNA processing factor 4 (PRP4) like Kelch_5 PF13854.6 ETO05007.1 - 0.38 10.8 2.0 2.3 8.3 0.7 3.0 3 0 0 3 3 3 0 Kelch motif DUF5113 PF17140.4 ETO05007.1 - 1 9.1 76.0 1.6 8.5 0.0 16.0 10 5 7 17 17 17 0 Domain of unknown function (DUF5113) NPR3 PF03666.13 ETO05008.1 - 0.34 9.6 16.2 0.57 8.9 16.2 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO05008.1 - 1.1 7.9 17.5 2 7.1 17.5 1.4 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO05010.1 - 9.5e-51 168.7 6.2 4.1e-10 40.1 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05010.1 - 1.8e-16 60.2 1.3 0.032 14.5 0.0 6.1 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05010.1 - 5.2e-10 38.8 0.2 0.45 9.4 0.0 5.6 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05010.1 - 8.8e-10 38.4 6.2 1.8e-05 24.2 0.5 3.7 2 2 0 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO05010.1 - 1.9e-06 26.7 0.0 0.001 17.7 0.0 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO05010.1 - 0.00012 21.9 6.6 2.1 8.4 0.0 6.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO05010.1 - 0.00057 19.1 0.8 0.033 13.3 0.0 2.1 1 1 1 2 2 2 2 Coatomer WD associated region DUF5570 PF17731.1 ETO05010.1 - 0.012 15.7 0.0 18 5.4 0.0 4.2 2 2 3 5 5 5 0 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO05010.1 - 0.015 14.2 0.0 1.6 7.5 0.0 2.7 3 1 1 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) Nup160 PF11715.8 ETO05010.1 - 0.078 11.6 0.5 0.8 8.3 0.1 2.8 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO05010.1 - 0.08 11.7 4.5 1.1 7.9 2.4 3.0 1 1 1 2 2 2 0 Nup133 N terminal like PALB2_WD40 PF16756.5 ETO05010.1 - 0.16 10.8 2.2 1.1 8.1 0.0 3.0 1 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETO05010.1 - 0.25 11.0 1.2 68 3.3 0.0 3.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Kelch_4 PF13418.6 ETO05011.1 - 1.9e-08 34.2 0.3 5.2e-05 23.2 0.0 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO05011.1 - 2.5e-08 33.9 7.1 0.00015 22.0 0.2 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO05011.1 - 1.2e-06 28.0 10.3 9.1e-06 25.2 0.4 2.9 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO05011.1 - 0.00024 20.9 6.9 0.0076 16.2 0.4 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO05011.1 - 0.0018 18.5 0.4 0.06 13.6 0.0 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO05011.1 - 0.053 13.5 0.6 0.053 13.5 0.6 3.9 4 0 0 4 4 4 0 Kelch motif DUF4274 PF14096.6 ETO05012.1 - 0.17 11.9 0.8 0.4 10.7 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4274) zf-RING_5 PF14634.6 ETO05013.1 - 0.0013 18.7 5.2 0.0022 17.9 5.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO05013.1 - 0.012 15.5 6.9 0.021 14.7 6.9 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO05013.1 - 0.012 15.6 5.3 0.025 14.6 5.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Zn_Tnp_IS91 PF14319.6 ETO05013.1 - 0.013 15.5 1.3 0.029 14.4 1.3 1.6 1 0 0 1 1 1 0 Transposase zinc-binding domain zf-ANAPC11 PF12861.7 ETO05013.1 - 0.026 14.6 0.6 0.045 13.8 0.6 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ETO05013.1 - 0.03 14.2 5.3 0.045 13.6 5.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO05013.1 - 0.14 12.6 7.0 0.22 11.9 7.0 1.3 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 ETO05013.1 - 0.29 11.0 6.0 0.56 10.1 6.0 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 PPAK PF02818.15 ETO05015.1 - 0.45 10.7 1.9 0.81 9.9 1.9 1.3 1 0 0 1 1 1 0 PPAK motif SGL PF08450.12 ETO05016.1 - 2.8e-06 27.1 0.2 0.0009 18.9 0.0 1.8 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region DUF1340 PF07067.11 ETO05018.1 - 0.014 14.8 0.1 0.017 14.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1340) DUF760 PF05542.11 ETO05018.1 - 0.072 13.4 0.0 0.098 13.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF760) zf-TRAF PF02176.18 ETO05019.1 - 2.6e-05 24.8 4.3 3.2e-05 24.5 0.7 2.2 2 1 0 2 2 2 1 TRAF-type zinc finger Ribosomal_S19e PF01090.19 ETO05020.1 - 2.2e-23 82.5 0.8 3.7e-23 81.7 0.8 1.3 1 0 0 1 1 1 1 Ribosomal protein S19e UPF0561 PF10573.9 ETO05020.1 - 0.059 13.5 0.6 0.11 12.6 0.6 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 HTH_12 PF08461.10 ETO05020.1 - 0.088 12.8 0.1 0.19 11.7 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease R winged-helix domain RuvB_C PF05491.13 ETO05020.1 - 0.15 12.0 0.0 0.38 10.7 0.0 1.7 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain dsDNA_bind PF01984.20 ETO05022.1 - 0.023 15.0 1.2 0.067 13.5 0.5 2.1 2 0 0 2 2 2 0 Double-stranded DNA-binding domain PepSY_2 PF13670.6 ETO05022.1 - 0.15 12.1 0.0 0.4 10.7 0.0 1.8 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Drf_GBD PF06371.13 ETO05024.1 - 2.5e-09 37.0 0.7 2.5e-09 37.0 0.7 2.1 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain DUF3361 PF11841.8 ETO05024.1 - 0.00059 19.8 0.1 0.0019 18.1 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF3361) Drf_FH1 PF06346.12 ETO05024.1 - 0.01 15.6 125.6 0.039 13.7 62.4 2.2 1 1 1 2 2 2 0 Formin Homology Region 1 CENP-F_leu_zip PF10473.9 ETO05024.1 - 0.01 15.9 11.3 0.01 15.9 11.3 2.4 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LETM1 PF07766.13 ETO05024.1 - 0.016 14.6 5.4 0.032 13.6 5.4 1.4 1 0 0 1 1 1 0 LETM1-like protein DUF745 PF05335.13 ETO05024.1 - 0.058 13.1 2.4 0.17 11.6 2.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DMPK_coil PF08826.10 ETO05024.1 - 0.45 10.7 7.9 8.1 6.6 0.2 2.7 1 1 0 2 2 2 0 DMPK coiled coil domain like SLATT_5 PF18160.1 ETO05024.1 - 0.61 9.4 4.1 1.3 8.3 4.1 1.4 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 TMPIT PF07851.13 ETO05024.1 - 3.1 7.0 5.7 6.7 5.9 5.7 1.5 1 0 0 1 1 1 0 TMPIT-like protein Drf_GBD PF06371.13 ETO05025.1 - 3.5e-08 33.2 1.4 4.2e-08 33.0 1.4 1.1 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain SIL1 PF16782.5 ETO05025.1 - 0.00077 18.8 0.1 0.0014 17.9 0.0 1.5 1 1 0 1 1 1 1 Nucleotide exchange factor SIL1 DUF3361 PF11841.8 ETO05025.1 - 0.048 13.6 1.1 0.12 12.3 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Ribos_L4_asso_C PF14374.6 ETO05025.1 - 0.12 12.5 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 60S ribosomal protein L4 C-terminal domain DUF3895 PF13034.6 ETO05025.1 - 0.12 12.4 0.1 3.6 7.6 0.0 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF3895) EntA_Immun PF08951.10 ETO05025.1 - 0.37 11.2 6.3 0.46 10.9 0.2 2.9 3 0 0 3 3 3 0 Enterocin A Immunity Trypan_PARP PF05887.11 ETO05026.1 - 0.072 13.1 0.0 0.11 12.5 0.0 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) KID PF02524.14 ETO05026.1 - 0.95 9.8 3.6 16 6.1 0.1 3.6 3 0 0 3 3 3 0 KID repeat zf-rbx1 PF12678.7 ETO05027.1 - 1.9e-10 40.9 5.9 4.1e-10 39.8 5.9 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO05027.1 - 0.00033 20.6 6.4 0.00071 19.6 6.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger ubiquitin PF00240.23 ETO05027.1 - 0.0048 16.6 1.5 0.014 15.1 0.8 2.2 1 1 1 2 2 2 1 Ubiquitin family zf-RING_2 PF13639.6 ETO05027.1 - 0.022 15.1 7.6 0.027 14.8 6.3 1.9 1 1 0 1 1 1 0 Ring finger domain LeuA_dimer PF08502.10 ETO05027.1 - 0.027 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 LeuA allosteric (dimerisation) domain zf-C3HC4_2 PF13923.6 ETO05027.1 - 0.2 11.5 4.5 0.63 9.9 4.5 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETO05027.1 - 0.49 10.1 9.8 1.1 9.0 3.7 2.5 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DUF4899 PF16240.5 ETO05028.1 - 0.015 14.5 0.1 0.031 13.5 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4899) PNK3P PF08645.11 ETO05028.1 - 0.015 15.0 0.1 0.023 14.4 0.1 1.3 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase DUF416 PF04222.12 ETO05028.1 - 0.026 13.9 0.2 0.052 13.0 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF416) MRI PF15325.6 ETO05029.1 - 7.4 7.7 8.4 4.7 8.3 0.5 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection WD40 PF00400.32 ETO05031.1 - 2.4e-30 104.1 21.9 1.3e-06 29.0 0.0 7.4 8 1 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05031.1 - 2e-12 47.3 0.6 0.0037 17.5 0.0 5.4 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05031.1 - 1.9e-07 30.1 0.2 1.2 7.7 0.0 4.3 2 2 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05031.1 - 1.8e-05 24.2 7.2 0.021 14.2 0.1 4.8 2 2 3 6 6 6 2 WD40-like domain Kelch_1 PF01344.25 ETO05032.1 - 5.9e-09 35.4 0.6 1.1e-05 25.0 0.2 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO05032.1 - 4.6e-08 32.7 7.5 7.2e-05 22.6 0.2 5.0 5 1 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO05032.1 - 2.9e-06 27.4 3.4 0.53 10.6 0.1 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO05032.1 - 0.0019 18.4 0.3 0.26 11.6 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO05032.1 - 0.0069 16.4 0.1 0.084 12.9 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO05032.1 - 0.042 13.9 8.8 4.4 7.4 0.0 4.4 5 0 0 5 5 5 0 Kelch motif DUF4160 PF13711.6 ETO05032.1 - 0.047 14.0 1.1 1.5 9.2 0.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4160) Aminotran_1_2 PF00155.21 ETO05034.1 - 6.4e-19 68.3 0.0 8.6e-19 67.9 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETO05034.1 - 2e-05 24.1 0.0 3.1e-05 23.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ETO05034.1 - 0.011 14.3 0.0 0.026 13.1 0.0 1.5 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme Peptidase_C14 PF00656.22 ETO05034.1 - 0.089 12.7 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 Caspase domain DUF3891 PF13030.6 ETO05036.1 - 0.11 12.3 0.1 0.19 11.5 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3891) Sigma_reg_N PF13800.6 ETO05038.1 - 0.034 14.4 0.0 0.079 13.3 0.0 1.7 1 0 0 1 1 1 0 Sigma factor regulator N-terminal LapA_dom PF06305.11 ETO05038.1 - 0.035 13.9 0.4 0.035 13.9 0.4 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain FxsA PF04186.13 ETO05038.1 - 0.061 13.4 0.2 0.11 12.7 0.2 1.4 1 0 0 1 1 1 0 FxsA cytoplasmic membrane protein DUF3810 PF12725.7 ETO05038.1 - 0.081 12.3 0.0 0.081 12.3 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) TarH PF02203.15 ETO05038.1 - 0.12 12.3 0.1 0.12 12.3 0.1 1.7 2 0 0 2 2 2 0 Tar ligand binding domain homologue MLANA PF14991.6 ETO05038.1 - 0.57 10.5 3.2 0.29 11.4 0.6 1.9 2 1 0 2 2 2 0 Protein melan-A Rrp44_S1 PF17215.3 ETO05038.1 - 4.3 7.4 6.3 1.9 8.5 0.4 2.4 2 1 0 2 2 2 0 S1 domain RPW8 PF05659.11 ETO05040.1 - 0.055 13.1 0.6 0.099 12.3 0.6 1.5 1 0 0 1 1 1 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 DUF3899 PF13038.6 ETO05040.1 - 4.3 7.9 8.8 0.29 11.6 0.4 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF3899) RNA_pol_L_2 PF13656.6 ETO05041.1 - 8.8e-23 79.9 0.0 1.5e-22 79.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_L PF01193.24 ETO05041.1 - 0.021 14.3 0.0 0.04 13.4 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Uteroglobin PF01099.17 ETO05041.1 - 0.073 13.4 1.7 0.16 12.4 1.7 1.5 1 0 0 1 1 1 0 Uteroglobin family DUF5052 PF16475.5 ETO05041.1 - 0.079 12.6 2.9 0.12 12.0 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5052) DUF2252 PF10009.9 ETO05041.1 - 0.27 10.3 3.1 0.36 9.9 3.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) CD36 PF01130.21 ETO05042.1 - 8e-34 117.0 7.5 9.9e-34 116.7 7.5 1.0 1 0 0 1 1 1 1 CD36 family ubiquitin PF00240.23 ETO05044.1 - 2.8e-19 68.6 0.1 5.1e-19 67.8 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO05044.1 - 2.2e-11 43.4 0.3 4.4e-11 42.5 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETO05044.1 - 6.7e-09 35.7 0.5 0.00019 21.4 0.1 2.5 1 1 1 2 2 2 2 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ETO05044.1 - 5.6e-05 23.5 0.1 0.0001 22.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO05044.1 - 0.0016 18.3 0.2 0.0081 16.1 0.1 2.2 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain UBX PF00789.20 ETO05044.1 - 0.12 12.6 0.0 0.21 11.8 0.0 1.3 1 0 0 1 1 1 0 UBX domain CNDH2_C PF16858.5 ETO05045.1 - 1.6 8.5 17.0 0.25 11.2 5.5 2.7 3 0 0 3 3 3 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2076 PF09849.9 ETO05045.1 - 7.5 6.5 23.1 15 5.5 23.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) ubiquitin PF00240.23 ETO05046.1 - 0.00029 20.5 0.1 0.001 18.8 0.1 2.0 1 1 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 ETO05046.1 - 0.19 12.3 0.2 0.19 12.3 0.2 2.6 1 1 1 2 2 2 0 DUF2407 ubiquitin-like domain DUF3394 PF11874.8 ETO05046.1 - 6.3 6.4 6.1 7.1 6.3 5.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3394) RRM_1 PF00076.22 ETO05047.1 - 3e-06 27.0 0.1 7.9e-06 25.6 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_A14 PF05767.12 ETO05047.1 - 0.059 13.5 0.5 0.11 12.6 0.5 1.5 1 0 0 1 1 1 0 Poxvirus virion envelope protein A14 EF-hand_6 PF13405.6 ETO05048.1 - 8e-07 28.5 0.1 0.011 15.6 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO05048.1 - 0.0001 22.7 5.9 0.0014 19.1 0.0 3.7 4 1 0 4 4 4 1 EF-hand domain pair RPEL PF02755.15 ETO05048.1 - 0.00016 21.3 0.1 0.032 13.9 0.2 3.4 2 0 0 2 2 2 1 RPEL repeat EF-hand_1 PF00036.32 ETO05048.1 - 0.00037 19.8 1.5 0.061 12.9 0.2 3.4 3 0 0 3 3 3 1 EF hand DUF2207 PF09972.9 ETO05048.1 - 0.00093 18.1 2.8 0.00093 18.1 2.8 3.1 3 0 0 3 3 3 1 Predicted membrane protein (DUF2207) EF-hand_5 PF13202.6 ETO05048.1 - 0.002 17.6 0.1 0.0065 15.9 0.1 2.0 1 0 0 1 1 1 1 EF hand Rab5-bind PF09311.11 ETO05048.1 - 0.042 13.2 49.3 0.13 11.7 10.6 2.3 1 1 1 2 2 2 0 Rabaptin-like protein EF-hand_7 PF13499.6 ETO05049.1 - 0.00015 22.1 0.1 0.00037 20.9 0.1 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO05049.1 - 0.00025 20.7 1.2 0.0024 17.7 0.2 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ETO05049.1 - 0.002 17.5 1.8 0.0047 16.4 0.3 2.4 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 ETO05049.1 - 0.032 13.7 0.2 0.093 12.3 0.2 1.8 1 0 0 1 1 1 0 EF hand PrgI PF12666.7 ETO05049.1 - 0.94 10.2 16.1 0.094 13.4 2.4 3.3 3 0 0 3 3 3 0 PrgI family protein Sec23_helical PF04815.15 ETO05050.1 - 0.02 14.7 1.0 2.6 7.9 0.0 4.2 4 1 1 5 5 5 0 Sec23/Sec24 helical domain Pro_3_hydrox_C PF05373.11 ETO05050.1 - 0.02 14.9 0.4 0.16 12.1 0.2 2.7 2 0 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal Ribosomal_L50 PF10501.9 ETO05050.1 - 0.025 14.7 2.0 1.3 9.2 0.1 3.8 3 1 0 3 3 3 0 Ribosomal subunit 39S DUF2267 PF10025.9 ETO05050.1 - 0.028 14.7 0.1 18 5.6 0.0 3.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2267) HOIP-UBA PF16678.5 ETO05050.1 - 0.05 13.6 0.3 0.05 13.6 0.3 2.7 2 1 1 3 3 3 0 HOIP UBA domain pair T3SS_basalb_I PF17001.5 ETO05050.1 - 0.16 12.5 4.2 22 5.7 0.1 4.1 3 1 0 4 4 4 0 Type III secretion basal body protein I, YscI, HrpB, PscI CarD_CdnL_TRCF PF02559.16 ETO05050.1 - 0.39 11.4 2.9 1.6 9.5 0.6 3.2 2 1 0 2 2 2 0 CarD-like/TRCF domain DUF1018 PF06252.12 ETO05050.1 - 0.43 11.6 2.9 1.1 10.2 0.0 3.1 3 1 0 3 3 3 0 Protein of unknown function (DUF1018) ATP-synt_F6 PF05511.11 ETO05050.1 - 2.2 8.7 6.6 1.4 9.3 0.3 3.5 3 1 0 3 3 3 0 Mitochondrial ATP synthase coupling factor 6 Rotamase PF00639.21 ETO05050.1 - 8.1 7.5 6.4 3.2 8.8 0.1 3.4 3 0 0 3 3 3 0 PPIC-type PPIASE domain zf-TRAF PF02176.18 ETO05051.1 - 0.00016 22.3 0.7 0.00016 22.3 0.7 2.8 3 0 0 3 3 3 2 TRAF-type zinc finger DUF4064 PF13273.6 ETO05052.1 - 0.022 15.0 2.4 0.036 14.4 2.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) CTXphi_pIII-N1 PF16710.5 ETO05052.1 - 0.13 12.4 2.4 4.4 7.4 0.1 3.0 2 1 1 3 3 3 0 N-terminal N1 domain of Vibrio phage CTXphi pIII DUF4426 PF14467.6 ETO05053.1 - 0.057 13.4 0.1 0.09 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4426) Taxilin PF09728.9 ETO05054.1 - 0.0015 17.8 35.2 0.0052 16.0 34.0 2.0 1 1 1 2 2 2 2 Myosin-like coiled-coil protein XhlA PF10779.9 ETO05054.1 - 0.11 12.8 3.4 0.75 10.0 0.1 2.6 2 0 0 2 2 2 0 Haemolysin XhlA DUF2207 PF09972.9 ETO05054.1 - 0.13 11.0 8.3 0.21 10.3 8.3 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-CCCH_3 PF15663.5 ETO05054.1 - 0.22 11.7 5.2 0.3 11.3 2.9 2.2 1 1 1 2 2 2 0 Zinc-finger containing family OmpH PF03938.14 ETO05054.1 - 0.34 11.3 18.8 0.037 14.4 6.6 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Nup54 PF13874.6 ETO05054.1 - 1.6 8.9 11.3 0.39 10.8 6.7 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Glyco_transf_15 PF01793.16 ETO05055.1 - 0.025 13.9 1.6 0.027 13.7 1.6 1.0 1 0 0 1 1 1 0 Glycolipid 2-alpha-mannosyltransferase Kelch_6 PF13964.6 ETO05056.1 - 0.0004 20.6 5.0 0.36 11.2 0.1 4.0 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO05056.1 - 0.00084 18.9 4.2 0.46 10.1 0.1 2.9 3 0 0 3 3 3 2 Kelch motif 2Fe-2S_thioredx PF01257.19 ETO05056.1 - 0.013 15.4 0.0 0.023 14.5 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin Kelch_2 PF07646.15 ETO05056.1 - 0.026 14.5 0.3 0.026 14.5 0.3 3.6 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO05056.1 - 0.063 13.3 0.2 10 6.2 0.1 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO05056.1 - 0.54 10.3 5.6 0.66 10.0 0.2 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO05057.1 - 0.0012 19.6 3.3 0.0012 19.6 3.3 3.0 3 1 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 ETO05058.1 - 5.1e-09 36.6 6.8 0.00018 22.2 0.5 3.6 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO05058.1 - 0.001 17.8 0.3 0.46 9.1 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Receptor_2B4 PF11465.8 ETO05058.1 - 0.077 13.2 0.1 0.11 12.7 0.1 1.4 1 1 0 1 1 1 0 Natural killer cell receptor 2B4 DUF679 PF05078.12 ETO05059.1 - 0.1 12.6 5.5 0.057 13.4 2.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF679) FokI_C PF02980.16 ETO05062.1 - 2.6 8.1 10.4 3 7.9 1.2 2.3 1 1 1 2 2 2 0 Restriction endonuclease FokI, catalytic domain Elf1 PF05129.13 ETO05063.1 - 0.017 15.2 0.0 0.044 13.8 0.0 1.7 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like DUF2024 PF09630.10 ETO05065.1 - 0.07 13.0 0.5 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF2024) DUF1751 PF08551.10 ETO05065.1 - 0.092 13.3 0.1 0.18 12.4 0.1 1.4 1 0 0 1 1 1 0 Eukaryotic integral membrane protein (DUF1751) DUF287 PF03384.14 ETO05065.1 - 0.3 11.5 0.3 0.3 11.5 0.3 2.7 1 1 2 3 3 3 0 Drosophila protein of unknown function, DUF287 Glyoxalase_6 PF18029.1 ETO05066.1 - 0.00024 21.8 0.0 0.00048 20.9 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase-like domain Glyoxalase PF00903.25 ETO05066.1 - 0.0017 18.6 0.0 0.0094 16.1 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ETO05066.1 - 0.058 13.3 0.1 0.47 10.4 0.0 2.3 1 1 1 2 2 2 0 Glyoxalase-like domain zf-DBF PF07535.12 ETO05068.1 - 0.34 11.0 1.5 0.86 9.8 1.5 1.6 1 0 0 1 1 1 0 DBF zinc finger KASH_CCD PF14662.6 ETO05069.1 - 0.0014 18.5 9.0 0.0023 17.8 9.0 1.3 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF3972 PF13118.6 ETO05069.1 - 0.033 14.6 4.5 0.13 12.7 4.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3972) Csm1_N PF18504.1 ETO05069.1 - 0.1 12.9 7.5 0.54 10.6 0.1 3.1 1 1 2 3 3 3 0 Csm1 N-terminal domain TPR_MLP1_2 PF07926.12 ETO05069.1 - 0.13 12.4 6.4 0.17 12.0 6.4 1.2 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 ETO05069.1 - 0.13 12.1 3.5 0.31 10.8 2.7 2.0 1 1 0 1 1 1 0 Septum formation initiator bZIP_1 PF00170.21 ETO05069.1 - 0.14 12.3 9.5 0.18 11.9 1.6 2.9 1 1 2 3 3 3 0 bZIP transcription factor DUF2570 PF10828.8 ETO05069.1 - 0.25 11.2 4.8 0.44 10.4 0.4 2.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2570) PRKG1_interact PF15898.5 ETO05069.1 - 0.32 11.9 8.6 0.54 11.2 7.0 2.0 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CENP-H PF05837.12 ETO05069.1 - 0.35 11.3 6.3 1 9.8 6.3 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) TMF_DNA_bd PF12329.8 ETO05069.1 - 0.51 10.4 9.7 0.26 11.3 5.4 2.4 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding BST2 PF16716.5 ETO05069.1 - 0.6 10.7 7.6 0.98 10.0 6.2 2.0 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 ZapB PF06005.12 ETO05069.1 - 0.69 10.4 8.7 0.18 12.3 1.4 2.3 1 1 1 2 2 2 0 Cell division protein ZapB Fungal_TACC PF12709.7 ETO05069.1 - 1.2 9.7 6.4 9.9 6.7 0.2 2.6 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins YabA PF06156.13 ETO05069.1 - 5.4 7.7 8.0 13 6.5 0.6 2.1 1 1 1 2 2 2 0 Initiation control protein YabA EF-hand_7 PF13499.6 ETO05070.1 - 9.2e-11 42.0 0.5 9.2e-11 42.0 0.5 2.5 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO05070.1 - 5.8e-10 38.0 2.8 0.00019 20.7 0.7 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO05070.1 - 8.9e-08 31.9 0.3 0.0034 17.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO05070.1 - 2.4e-07 30.1 3.8 0.0068 16.2 0.5 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO05070.1 - 1.2e-05 24.6 2.6 0.016 14.7 0.2 2.8 2 0 0 2 2 2 2 EF hand KLRAQ PF10205.9 ETO05070.1 - 0.00027 21.1 8.9 0.00066 19.9 5.5 2.6 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein SPARC_Ca_bdg PF10591.9 ETO05070.1 - 0.0022 18.3 0.6 0.0022 18.3 0.6 3.1 2 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETO05070.1 - 0.0052 17.1 0.3 6.1 7.3 0.1 2.7 2 0 0 2 2 2 2 EF-hand domain DUF496 PF04363.12 ETO05070.1 - 0.012 15.6 0.2 0.033 14.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF496) DUF4164 PF13747.6 ETO05070.1 - 0.019 15.3 4.2 0.039 14.2 4.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Tox-REase-5 PF15648.6 ETO05070.1 - 0.043 14.3 3.0 0.06 13.9 0.3 2.4 2 1 0 2 2 2 0 Restriction endonuclease fold toxin 5 ZapB PF06005.12 ETO05070.1 - 0.047 14.1 10.0 0.047 14.1 10.0 2.9 2 1 1 3 3 3 0 Cell division protein ZapB DUF3450 PF11932.8 ETO05070.1 - 0.054 12.8 8.3 0.13 11.5 7.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.15 ETO05070.1 - 0.22 11.3 14.4 0.27 11.0 5.0 3.6 3 1 1 4 4 4 0 Septum formation initiator Sec20 PF03908.13 ETO05070.1 - 0.79 9.7 4.8 0.48 10.4 1.7 2.2 3 0 0 3 3 2 0 Sec20 Syntaxin_2 PF14523.6 ETO05070.1 - 0.96 9.8 8.4 0.58 10.6 3.8 2.4 2 0 0 2 2 2 0 Syntaxin-like protein Seryl_tRNA_N PF02403.22 ETO05070.1 - 1.2 9.4 12.7 0.21 11.8 6.7 2.5 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 ETO05070.1 - 2.9 8.3 10.4 0.59 10.6 4.5 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 ETO05070.1 - 5.1 7.5 14.5 0.57 10.6 7.6 2.6 3 0 0 3 3 3 0 Centromere protein H (CENP-H) Retrotrans_gag PF03732.17 ETO05070.1 - 6.2 7.2 8.4 3 8.2 3.4 2.6 2 1 1 3 3 3 0 Retrotransposon gag protein Chitin_synth_2 PF03142.15 ETO05071.1 - 0.065 11.8 0.0 0.075 11.6 0.0 1.1 1 0 0 1 1 1 0 Chitin synthase WD40 PF00400.32 ETO05072.1 - 2.5e-07 31.3 7.6 0.016 16.1 0.6 6.1 6 1 0 6 6 6 3 WD domain, G-beta repeat DAGK_cat PF00781.24 ETO05072.1 - 0.026 14.1 0.1 0.42 10.2 0.0 2.4 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain DHHC PF01529.20 ETO05073.1 - 0.016 15.3 0.5 0.016 15.3 0.5 2.7 2 1 0 2 2 2 0 DHHC palmitoyltransferase AAA_33 PF13671.6 ETO05074.1 - 0.022 14.9 0.0 0.045 13.9 0.0 1.5 1 1 0 1 1 1 0 AAA domain HVSL PF09749.9 ETO05075.1 - 6.9e-49 166.5 5.1 9.6e-49 166.0 5.1 1.1 1 0 0 1 1 1 1 Uncharacterised conserved protein POTRA_2 PF08479.11 ETO05075.1 - 0.11 12.3 0.3 2.4 8.1 0.1 2.6 2 1 0 2 2 2 0 POTRA domain, ShlB-type ORC6 PF05460.13 ETO05075.1 - 0.19 11.0 4.0 1 8.5 3.9 1.9 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Ycf70 PF17382.2 ETO05076.1 - 0.056 13.9 0.7 0.056 13.9 0.7 2.2 3 0 0 3 3 3 0 Uncharacterized Ycf70-like MVP_shoulder PF11978.8 ETO05076.1 - 0.061 13.4 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Shoulder domain DUF3069 PF11269.8 ETO05078.1 - 0.32 11.3 3.1 0.39 11.0 1.5 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3069) DUF2457 PF10446.9 ETO05078.1 - 0.51 9.4 13.1 0.9 8.6 13.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CPSF100_C PF13299.6 ETO05078.1 - 1.6 8.9 9.0 1.3 9.2 5.3 2.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal SDA1 PF05285.12 ETO05078.1 - 4.9 6.5 18.8 9 5.6 18.8 1.4 1 1 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 ETO05078.1 - 9.8 4.1 14.5 18 3.2 14.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi NACHT PF05729.12 ETO05079.1 - 0.012 15.6 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 0 NACHT domain NB-ARC PF00931.22 ETO05079.1 - 0.077 12.2 2.5 0.085 12.0 0.0 2.1 2 1 0 2 2 2 0 NB-ARC domain DUF3911 PF13050.6 ETO05079.1 - 1.5 9.0 6.7 2 8.6 1.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3911) TPR_2 PF07719.17 ETO05082.1 - 4.5e-08 32.6 0.5 0.026 14.6 0.3 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05082.1 - 3.1e-06 26.8 4.3 0.071 13.0 1.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO05082.1 - 0.00012 22.6 2.9 0.048 14.2 0.1 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO05082.1 - 0.0003 20.9 0.1 0.011 15.9 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO05082.1 - 0.00092 19.4 1.3 0.00092 19.4 1.3 3.5 3 1 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETO05082.1 - 0.0011 19.0 4.4 12 6.4 0.4 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05082.1 - 0.038 14.0 2.1 6.7 7.0 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Curto_V2 PF07325.11 ETO05083.1 - 0.47 10.3 4.1 0.23 11.4 0.7 2.2 2 0 0 2 2 2 0 Curtovirus V2 protein HATPase_c PF02518.26 ETO05086.1 - 0.087 13.3 0.0 0.15 12.6 0.0 1.4 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase MADF_DNA_bdg PF10545.9 ETO05087.1 - 0.19 12.0 4.5 0.62 10.4 1.7 3.6 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like FISNA PF14484.6 ETO05090.1 - 0.00046 20.3 2.0 0.00088 19.4 2.0 1.4 1 0 0 1 1 1 1 Fish-specific NACHT associated domain dsRBD2 PF17842.1 ETO05090.1 - 0.21 11.8 4.0 0.25 11.6 4.0 1.2 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 DUF3112 PF11309.8 ETO05090.1 - 1.6 8.2 3.4 1.1 8.6 1.6 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3112) DUF4800 PF16057.5 ETO05091.1 - 0.031 13.5 0.1 0.056 12.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4800) SRTM1 PF15872.5 ETO05093.1 - 0.12 12.5 1.8 12 6.1 0.5 3.1 3 0 0 3 3 3 0 Serine-rich and transmembrane domain-containing protein 1 Leu_Phe_trans PF03588.14 ETO05094.1 - 4.2e-16 58.9 0.0 3.9e-11 42.8 0.0 2.6 2 0 0 2 2 2 2 Leucyl/phenylalanyl-tRNA protein transferase RNA_pol_Rpc4 PF05132.14 ETO05094.1 - 0.17 12.3 8.0 0.096 13.1 0.6 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Na_trans_assoc PF06512.13 ETO05094.1 - 8.8 6.6 12.1 0.096 13.0 1.3 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated Clathrin PF00637.20 ETO05095.1 - 3.6e-152 500.2 26.4 2.1e-31 108.7 0.4 6.1 6 0 0 6 6 6 6 Region in Clathrin and VPS Coatomer_WDAD PF04053.14 ETO05095.1 - 0.00057 19.0 1.7 0.18 10.8 0.1 2.4 2 0 0 2 2 2 2 Coatomer WD associated region TPR_14 PF13428.6 ETO05095.1 - 0.00077 20.1 4.4 6.5 7.8 0.0 6.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05095.1 - 0.017 15.3 0.1 9 6.8 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA_23 PF13476.6 ETO05095.1 - 2.8 8.4 9.8 0.17 12.3 0.9 2.6 2 1 0 2 2 2 0 AAA domain Clathrin_H_link PF13838.6 ETO05096.1 - 8.4e-17 60.8 1.5 1.8e-16 59.8 0.3 2.1 2 0 0 2 2 2 1 Clathrin-H-link Clathrin PF00637.20 ETO05096.1 - 4.5e-16 59.0 4.4 2.9e-15 56.4 0.2 3.2 2 1 0 3 3 3 1 Region in Clathrin and VPS Clathrin_propel PF01394.20 ETO05096.1 - 3.8e-06 26.9 0.0 0.0043 17.3 0.1 3.4 3 0 0 3 3 3 2 Clathrin propeller repeat KCT2 PF17818.1 ETO05096.1 - 0.053 13.6 0.0 0.096 12.8 0.0 1.3 1 0 0 1 1 1 0 Keratinocyte-associated gene product Fungal_lectin PF07938.12 ETO05097.1 - 0.072 12.5 0.0 0.085 12.2 0.0 1.1 1 0 0 1 1 1 0 Fungal fucose-specific lectin NifU PF01106.17 ETO05098.1 - 1e-26 92.9 0.0 1.8e-26 92.1 0.0 1.4 1 0 0 1 1 1 1 NifU-like domain DUF1338 PF07063.13 ETO05098.1 - 5.7e-05 22.5 0.0 7.7e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1338) WD40 PF00400.32 ETO05099.1 - 3.6e-63 208.0 20.6 3e-10 40.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05099.1 - 3.7e-19 68.8 2.7 0.076 13.3 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05099.1 - 3.6e-09 35.8 3.3 0.024 13.3 0.0 5.6 1 1 5 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05099.1 - 1.5e-07 31.1 2.4 0.21 10.9 0.0 4.3 1 1 4 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 ETO05099.1 - 2.8e-07 29.8 2.7 5.4 5.9 0.0 6.0 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Bet_v_1 PF00407.19 ETO05099.1 - 0.15 12.0 0.9 3.3 7.6 0.2 2.7 2 0 0 2 2 2 0 Pathogenesis-related protein Bet v I family PD40 PF07676.12 ETO05099.1 - 0.62 10.1 12.5 28 4.8 0.1 6.1 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat WRNPLPNID PF15017.6 ETO05100.1 - 2.4 9.1 9.2 1 10.2 6.2 1.9 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DUF2097 PF09870.9 ETO05101.1 - 0.29 11.4 4.8 1.5 9.1 1.3 2.3 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2097) WD40 PF00400.32 ETO05103.1 - 8e-29 99.3 20.5 2.7e-06 28.0 0.0 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05103.1 - 3.7e-09 36.8 0.5 0.002 18.4 0.0 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05103.1 - 1.2e-08 34.1 1.0 0.072 11.7 0.0 4.0 2 1 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05103.1 - 2.5e-05 23.7 2.0 0.088 12.1 0.1 3.3 1 1 1 3 3 3 2 WD40-like domain LydB PF16084.5 ETO05103.1 - 0.013 15.3 0.1 3.4 7.5 0.0 2.1 2 0 0 2 2 2 0 LydA-holin antagonist SH3_13 PF18335.1 ETO05103.1 - 0.033 14.0 0.0 1 9.2 0.0 2.9 3 0 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain Peptidase_C9 PF01707.16 ETO05103.1 - 0.081 12.5 0.0 19 4.8 0.0 3.0 3 1 0 3 3 3 0 Peptidase family C9 PSII_Pbs27 PF13326.6 ETO05105.1 - 0.026 14.9 0.9 1.5 9.1 0.2 2.7 2 0 0 2 2 2 0 Photosystem II Pbs27 VPS11_C PF12451.8 ETO05105.1 - 6 7.2 11.6 5.2 7.4 0.1 4.1 3 0 0 3 3 3 0 Vacuolar protein sorting protein 11 C terminal HSP70 PF00012.20 ETO05106.1 - 0.0021 16.4 0.0 0.0022 16.3 0.0 1.0 1 0 0 1 1 1 1 Hsp70 protein Kinocilin PF15033.6 ETO05106.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.4 2 0 0 2 2 2 0 Kinocilin protein TSP_NTD PF17804.1 ETO05107.1 - 0.093 13.0 6.7 0.1 12.9 6.7 1.1 1 0 0 1 1 1 0 Tail specific protease N-terminal domain Fib_alpha PF08702.10 ETO05107.1 - 0.1 12.8 4.4 0.13 12.5 4.4 1.1 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family RNase_J_C PF17770.1 ETO05107.1 - 0.42 11.7 6.3 0.23 12.5 4.5 1.5 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain TPD52 PF04201.15 ETO05107.1 - 1.7 8.2 9.8 0.58 9.8 2.1 2.1 1 1 1 2 2 2 0 Tumour protein D52 family PRP1_N PF06424.12 ETO05107.1 - 8.7 6.7 8.9 13 6.1 8.9 1.4 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF423 PF04241.15 ETO05108.1 - 0.2 11.9 1.0 0.75 10.0 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF423) Ank_2 PF12796.7 ETO05109.1 - 0.0041 17.7 0.0 0.0085 16.7 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF4248 PF14053.6 ETO05109.1 - 0.022 14.8 0.1 5.9 7.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) DUF4820 PF16091.5 ETO05109.1 - 0.07 12.5 8.5 0.14 11.5 8.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TPR_20 PF14561.6 ETO05109.1 - 0.097 13.0 1.1 2.1 8.7 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Presenilin PF01080.17 ETO05109.1 - 2.9 6.6 10.8 3.9 6.1 10.8 1.2 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO05109.1 - 3.3 5.8 25.3 4.2 5.5 25.3 1.2 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO05109.1 - 5.2 5.2 18.8 5.9 5.0 18.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 ETO05109.1 - 7 5.7 25.6 12 4.9 25.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TLD PF07534.16 ETO05110.1 - 5.9e-11 42.7 2.5 1.1e-10 41.9 0.1 2.8 3 0 0 3 3 3 1 TLD Rrp44_S1 PF17215.3 ETO05110.1 - 5.2 7.1 7.3 8.3 6.4 0.1 3.7 4 0 0 4 4 4 0 S1 domain DUF2207 PF09972.9 ETO05111.1 - 0.0053 15.6 2.3 0.0062 15.3 2.3 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) WD40 PF00400.32 ETO05112.1 - 5.9e-05 23.8 1.2 0.00062 20.5 0.2 2.3 2 1 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO05112.1 - 0.13 10.9 0.0 0.14 10.8 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 PAD_M PF08527.10 ETO05113.1 - 0.0085 15.8 0.2 0.018 14.7 0.1 1.7 1 1 0 1 1 1 1 Protein-arginine deiminase (PAD) middle domain ELH PF02323.15 ETO05114.1 - 0.019 14.3 0.1 0.032 13.6 0.1 1.3 1 0 0 1 1 1 0 Egg-laying hormone precursor WD40 PF00400.32 ETO05115.1 - 4.2e-13 49.5 7.6 8.3e-09 35.9 1.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05115.1 - 0.0018 18.6 0.0 0.0029 17.9 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05115.1 - 0.0018 17.0 0.1 0.0021 16.8 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 WD40 PF00400.32 ETO05116.1 - 1.1e-55 184.3 19.2 8.9e-11 42.2 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05116.1 - 2.1e-24 85.7 4.7 0.00014 22.1 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05116.1 - 4.3e-19 68.7 0.2 0.00057 18.9 0.0 5.8 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05116.1 - 2e-09 36.7 2.1 0.02 13.5 0.1 4.3 3 1 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05116.1 - 9e-08 31.8 0.0 0.024 14.0 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO05116.1 - 9.4e-07 28.6 6.9 7.5 6.6 0.1 6.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO05116.1 - 0.00028 19.5 3.8 0.24 9.9 0.2 3.6 1 1 3 4 4 4 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO05116.1 - 0.0053 16.9 1.7 8.2 6.5 0.1 3.6 3 1 1 4 4 4 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO05116.1 - 0.007 15.2 4.2 0.14 10.8 0.3 3.4 1 1 3 4 4 4 1 Nup133 N terminal like SoxZ PF08770.11 ETO05116.1 - 0.043 13.6 0.0 3.9 7.3 0.0 3.0 3 0 0 3 3 3 0 Sulphur oxidation protein SoxZ PQQ PF01011.21 ETO05116.1 - 0.11 12.5 0.0 27 4.9 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat PPR_2 PF13041.6 ETO05117.1 - 3.7e-16 59.0 8.1 1.2e-07 31.8 0.2 5.0 4 1 1 5 5 5 4 PPR repeat family PPR PF01535.20 ETO05117.1 - 6.1e-14 51.2 6.0 1.8e-05 24.7 0.1 4.9 5 0 0 5 5 5 3 PPR repeat PPR_3 PF13812.6 ETO05117.1 - 2.5e-13 49.9 6.1 9.2e-05 22.4 0.1 5.1 3 1 2 5 5 5 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO05117.1 - 1.9e-08 33.9 5.7 5e-05 22.9 0.0 4.8 5 0 0 5 5 5 2 PPR repeat PPR_long PF17177.4 ETO05117.1 - 3.5e-07 29.8 0.0 5.6e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO05117.1 - 0.0081 16.0 1.8 0.041 13.7 0.1 3.0 2 2 1 3 3 3 1 Mitochondrial ATPase expression F-box-like PF12937.7 ETO05118.1 - 2.1e-06 27.5 0.9 5.3e-06 26.2 0.9 1.7 1 0 0 1 1 1 1 F-box-like 2OG-FeII_Oxy_3 PF13640.6 ETO05118.1 - 0.027 15.3 0.0 0.052 14.4 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily FAM176 PF14851.6 ETO05119.1 - 0.74 9.5 3.6 1.4 8.6 3.6 1.4 1 0 0 1 1 1 0 FAM176 family zf-C3H2C3 PF17122.5 ETO05119.1 - 2.4 8.3 5.5 2.1 8.5 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger WD40 PF00400.32 ETO05120.1 - 7.3e-29 99.4 33.2 2.1e-06 28.3 0.7 7.9 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05120.1 - 1.3e-08 35.0 2.1 1.5 9.1 0.0 6.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05120.1 - 3.1e-08 32.7 1.8 0.19 10.3 0.1 5.1 3 2 3 6 6 6 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO05120.1 - 0.025 13.3 3.3 0.7 8.6 0.3 2.8 2 1 1 3 3 3 0 Nup133 N terminal like WD40_like PF17005.5 ETO05120.1 - 0.038 13.3 7.9 0.4 9.9 0.5 3.9 2 1 1 3 3 3 0 WD40-like domain Kelch_6 PF13964.6 ETO05121.1 - 4.2e-06 26.8 0.7 3.8e-05 23.8 0.0 2.4 1 1 1 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO05121.1 - 0.078 12.6 0.9 0.14 11.7 0.1 1.8 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO05121.1 - 0.13 12.3 0.7 0.74 9.9 0.2 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO05121.1 - 0.17 11.9 0.0 0.37 10.8 0.0 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain Intein_splicing PF14890.6 ETO05123.1 - 0.082 12.8 1.6 0.25 11.3 1.6 1.8 1 0 0 1 1 1 0 Intein splicing domain HigB_toxin PF09907.9 ETO05123.1 - 0.16 12.2 0.9 0.43 10.8 0.1 2.2 2 0 0 2 2 2 0 HigB_toxin, RelE-like toxic component of a toxin-antitoxin system WD40 PF00400.32 ETO05125.1 - 2.4e-37 126.3 24.1 7.3e-06 26.6 0.8 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO05125.1 - 2.4e-09 36.4 2.8 0.011 14.5 0.0 5.5 3 2 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05125.1 - 2.4e-07 31.0 1.1 2.2 8.6 0.0 5.8 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Presenilin PF01080.17 ETO05126.1 - 0.037 12.8 4.3 0.039 12.7 4.3 1.1 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 ETO05126.1 - 0.05 13.8 4.4 0.059 13.6 4.4 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ETO05126.1 - 0.051 13.3 2.7 0.064 13.0 2.7 1.2 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 ETO05126.1 - 0.052 13.3 3.3 0.078 12.7 3.3 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CDC45 PF02724.14 ETO05126.1 - 0.063 11.6 10.8 0.067 11.5 10.8 1.0 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO05126.1 - 0.1 13.0 3.8 0.13 12.7 3.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSG2 PF16965.5 ETO05126.1 - 0.12 11.3 2.4 0.17 10.8 2.4 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 ETO05126.1 - 0.73 8.8 2.0 0.83 8.6 2.0 1.1 1 0 0 1 1 1 0 CLN3 protein NPR3 PF03666.13 ETO05126.1 - 1.2 7.8 10.6 1.3 7.7 10.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RRN3 PF05327.11 ETO05126.1 - 2 6.9 7.8 2.3 6.6 7.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RNA_polI_A34 PF08208.11 ETO05126.1 - 4.6 7.3 15.8 5.9 6.9 15.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Zip PF02535.22 ETO05126.1 - 6.1 6.0 7.9 7.3 5.7 7.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter zf-MIZ PF02891.20 ETO05128.1 - 1.7e-05 24.5 0.9 3.2e-05 23.6 0.3 1.8 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger DUF2207 PF09972.9 ETO05128.1 - 1 8.0 14.8 1.7 7.3 14.8 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MCM_OB PF17207.3 ETO05129.1 - 3e-17 62.6 6.3 8.1e-11 41.9 5.8 2.2 2 0 0 2 2 2 2 MCM OB domain MCM PF00493.23 ETO05129.1 - 0.028 13.5 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 MCM P-loop domain Phage_TAC_1 PF06222.11 ETO05129.1 - 0.044 13.6 0.0 0.083 12.7 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone RPA_interact_N PF14766.6 ETO05129.1 - 1.1 8.9 3.0 3.6 7.3 0.4 2.4 2 0 0 2 2 2 0 Replication protein A interacting N-terminal DUF4538 PF15061.6 ETO05130.1 - 0.046 13.5 0.2 0.39 10.5 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4538) DUF2651 PF10852.8 ETO05130.1 - 0.21 12.2 1.5 0.43 11.2 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2651) FAD_binding_4 PF01565.23 ETO05132.1 - 0.015 15.0 0.0 0.024 14.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain YebG PF07130.12 ETO05133.1 - 0.036 13.9 0.2 0.067 13.0 0.2 1.5 1 0 0 1 1 1 0 YebG protein SOG2 PF10428.9 ETO05134.1 - 0.03 13.5 25.9 0.036 13.3 25.9 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Menin PF05053.13 ETO05134.1 - 0.056 11.8 26.3 0.088 11.2 26.3 1.3 1 0 0 1 1 1 0 Menin Dapper PF15268.6 ETO05134.1 - 1.2 7.9 26.5 1.5 7.6 26.5 1.0 1 0 0 1 1 1 0 Dapper CAC1F_C PF16885.5 ETO05134.1 - 2 8.0 18.2 3.2 7.3 18.2 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term WD40 PF00400.32 ETO05135.1 - 1.2e-26 92.4 18.9 1e-07 32.5 0.3 7.0 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05135.1 - 1.6e-06 28.3 1.9 0.0018 18.6 0.3 4.5 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05135.1 - 0.00072 18.3 5.7 0.47 9.0 0.7 3.6 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ribosomal_S27e PF01667.17 ETO05135.1 - 0.063 13.0 0.2 0.18 11.6 0.2 1.7 1 0 0 1 1 1 0 Ribosomal protein S27 Ac81 PF05820.11 ETO05135.1 - 0.33 10.5 9.3 0.17 11.4 7.0 1.7 2 0 0 2 2 2 0 Baculoviridae AC81 WD40 PF00400.32 ETO05136.1 - 1.1e-11 45.1 0.4 5.9e-06 26.9 0.1 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05136.1 - 0.013 15.8 0.0 0.08 13.3 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4248 PF14053.6 ETO05136.1 - 0.074 13.1 0.2 3.5 7.7 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4248) PDZ_6 PF17820.1 ETO05137.1 - 0.00036 20.3 0.0 0.00063 19.5 0.0 1.4 1 0 0 1 1 1 1 PDZ domain vATP-synt_E PF01991.18 ETO05138.1 - 0.019 14.4 1.1 0.022 14.1 1.1 1.2 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Nup54 PF13874.6 ETO05139.1 - 6.6 6.8 13.0 0.086 13.0 1.0 2.8 1 1 1 3 3 3 0 Nucleoporin complex subunit 54 Rad60-SLD PF11976.8 ETO05142.1 - 1.8e-06 27.7 0.1 1.8e-06 27.7 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETO05142.1 - 0.04 13.7 0.1 0.04 13.7 0.1 2.1 2 0 0 2 2 2 0 Ubiquitin family STT3_PglB_C PF18527.1 ETO05143.1 - 0.31 11.2 5.3 0.63 10.2 5.3 1.6 1 1 0 1 1 1 0 STT3/PglB C-terminal beta-barrel domain PH PF00169.29 ETO05145.1 - 2.8e-12 47.1 0.7 5.4e-12 46.2 0.7 1.4 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO05145.1 - 7.4e-08 32.4 0.7 5.1e-07 29.8 0.7 2.0 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO05145.1 - 2.1e-05 24.9 1.7 8.7e-05 22.9 1.7 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ETO05145.1 - 0.00089 19.5 0.4 0.0073 16.6 0.4 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain GxGYxYP_N PF16216.5 ETO05145.1 - 0.023 14.9 0.1 0.047 13.9 0.1 1.4 1 1 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal Creatinase_N_2 PF16189.5 ETO05145.1 - 0.032 14.3 0.3 0.088 12.9 0.1 1.8 1 1 1 2 2 2 0 Creatinase/Prolidase N-terminal domain Mcp5_PH PF12814.7 ETO05145.1 - 0.066 13.3 0.1 0.13 12.4 0.1 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology DUF5380 PF17351.2 ETO05145.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5380) CD34_antigen PF06365.12 ETO05146.1 - 0.017 14.7 1.9 0.021 14.4 1.9 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family Tubulin PF00091.25 ETO05148.1 - 6.3e-48 163.6 1.9 4.2e-47 160.9 1.2 2.6 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO05148.1 - 4e-42 143.4 0.1 6.8e-42 142.6 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO05148.1 - 0.00013 22.2 0.0 0.00029 21.1 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain IBR PF01485.21 ETO05149.1 - 0.074 13.3 27.6 0.056 13.7 2.1 4.3 2 2 2 4 4 4 0 IBR domain, a half RING-finger domain DUF2553 PF10830.8 ETO05151.1 - 0.11 13.4 1.9 0.13 13.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) CAP_GLY PF01302.25 ETO05152.1 - 0.00033 20.6 0.0 0.0025 17.8 0.0 2.2 2 0 0 2 2 2 1 CAP-Gly domain APAF1_C PF17908.1 ETO05153.1 - 0.57 10.2 4.9 0.69 9.9 0.8 2.8 2 1 1 3 3 3 0 APAF-1 helical domain F-box PF00646.33 ETO05154.1 - 0.087 12.7 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 F-box domain ATP-grasp_4 PF13535.6 ETO05155.1 - 0.068 12.8 0.0 0.12 12.0 0.0 1.3 1 0 0 1 1 1 0 ATP-grasp domain Peptidase_M23 PF01551.22 ETO05156.1 - 0.11 12.7 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M23 ART PF01129.18 ETO05156.1 - 0.12 11.7 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase AIG1 PF04548.16 ETO05157.1 - 0.088 12.1 1.9 0.091 12.1 0.5 1.6 1 1 1 2 2 2 0 AIG1 family GETHR PF05671.11 ETO05159.1 - 0.075 12.4 0.6 0.11 11.9 0.6 1.2 1 0 0 1 1 1 0 GETHR pentapeptide repeat (5 copies) Peptidase_S3 PF00944.19 ETO05161.1 - 0.11 12.4 0.0 0.27 11.0 0.0 1.6 1 1 1 2 2 2 0 Alphavirus core protein Surfac_D-trimer PF09006.11 ETO05162.1 - 0.089 12.7 0.2 0.16 11.8 0.2 1.5 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation 7tm_6 PF02949.20 ETO05163.1 - 0.038 13.1 2.3 0.059 12.4 2.3 1.3 1 1 0 1 1 1 0 7tm Odorant receptor Ureide_permease PF07168.11 ETO05163.1 - 0.26 10.0 3.2 0.32 9.7 3.2 1.1 1 0 0 1 1 1 0 Ureide permease DUF2052 PF09747.9 ETO05163.1 - 0.37 10.9 8.5 0.47 10.6 8.5 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Jak1_Phl PF17887.1 ETO05163.1 - 2 8.4 7.7 5.7 6.9 7.8 1.7 1 1 1 2 2 2 0 Jak1 pleckstrin homology-like domain FH2 PF02181.23 ETO05164.1 - 1.1e-10 41.2 5.3 1.1e-10 41.2 5.3 2.4 1 1 1 2 2 2 1 Formin Homology 2 Domain JmjN PF02375.17 ETO05164.1 - 0.036 14.0 0.1 0.18 11.8 0.0 2.2 2 0 0 2 2 2 0 jmjN domain DUF4746 PF15928.5 ETO05164.1 - 0.36 10.2 21.0 19 4.5 21.0 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) hDGE_amylase PF14701.6 ETO05164.1 - 2.4 7.1 12.7 2.8 6.9 12.7 1.2 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain DUF4554 PF15091.6 ETO05164.1 - 6.1 5.6 7.7 8.3 5.2 7.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Menin PF05053.13 ETO05165.1 - 0.0029 16.0 5.4 0.003 16.0 5.4 1.1 1 0 0 1 1 1 1 Menin SOG2 PF10428.9 ETO05165.1 - 0.39 9.8 6.6 0.45 9.7 6.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein NST1 PF13945.6 ETO05165.1 - 5.7 7.0 14.5 7.9 6.5 14.5 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 ETO05165.1 - 5.9 5.5 6.6 7.2 5.3 6.6 1.1 1 0 0 1 1 1 0 Presenilin DUF3437 PF11919.8 ETO05166.1 - 1.2e-32 111.6 0.2 6.2e-32 109.4 0.0 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF3437) MMS19_N PF14500.6 ETO05166.1 - 0.0021 17.7 1.2 0.03 13.9 0.1 2.3 1 1 1 2 2 2 2 Dos2-interacting transcription regulator of RNA-Pol-II CDT1_C PF16679.5 ETO05166.1 - 0.038 14.4 0.1 0.11 13.0 0.1 1.8 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain AAA_32 PF13654.6 ETO05167.1 - 0.005 15.7 4.7 0.0062 15.4 4.7 1.1 1 0 0 1 1 1 1 AAA domain Toxin_21 PF08091.11 ETO05167.1 - 0.0073 16.2 1.8 0.011 15.7 1.8 1.2 1 0 0 1 1 1 1 Spider insecticidal peptide Sds3 PF08598.11 ETO05167.1 - 0.017 15.1 6.3 0.027 14.5 6.3 1.3 1 0 0 1 1 1 0 Sds3-like Rieske PF00355.26 ETO05168.1 - 2.5e-09 36.9 0.0 3.7e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain G-alpha PF00503.20 ETO05169.1 - 4.2e-51 174.2 6.8 2.8e-50 171.5 3.7 2.2 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO05169.1 - 8.4e-06 25.3 0.1 6.6e-05 22.4 0.0 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family SnoaL_2 PF12680.7 ETO05170.1 - 0.026 15.2 0.0 0.23 12.1 0.0 2.3 2 1 1 3 3 3 0 SnoaL-like domain PUB PF09409.10 ETO05171.1 - 0.018 14.9 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 PUB domain RhlB PF12300.8 ETO05171.1 - 0.11 12.6 0.8 0.13 12.4 0.8 1.1 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB zf-RanBP PF00641.18 ETO05172.1 - 0.02 14.2 0.6 0.038 13.3 0.6 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others ETRAMP PF09716.10 ETO05172.1 - 0.025 14.6 0.4 0.029 14.4 0.4 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) zf-CCHC_3 PF13917.6 ETO05173.1 - 3.5e-06 26.9 1.0 3.5e-06 26.9 1.0 2.2 2 0 0 2 2 2 1 Zinc knuckle LAP1C PF05609.12 ETO05173.1 - 0.0051 16.0 25.8 0.0061 15.7 25.8 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) NICE-3 PF07406.11 ETO05173.1 - 0.038 14.0 1.2 0.065 13.2 1.2 1.4 1 0 0 1 1 1 0 NICE-3 protein DUF936 PF06075.12 ETO05173.1 - 0.15 10.9 33.3 0.19 10.6 33.3 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Hamartin PF04388.12 ETO05173.1 - 0.25 9.9 26.7 0.31 9.6 26.7 1.0 1 0 0 1 1 1 0 Hamartin protein Peptidase_S64 PF08192.11 ETO05173.1 - 0.94 7.9 34.8 1.2 7.5 34.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 Totivirus_coat PF05518.11 ETO05173.1 - 1.1 7.2 7.7 1.4 6.9 7.7 1.1 1 0 0 1 1 1 0 Totivirus coat protein Mitofilin PF09731.9 ETO05173.1 - 2.6 6.8 41.3 3.3 6.4 41.3 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PI3K_1B_p101 PF10486.9 ETO05173.1 - 6.4 4.4 23.0 7.3 4.2 23.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GREB1 PF15782.5 ETO05173.1 - 8.4 3.4 26.1 9.9 3.1 26.1 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer O-antigen_lig PF13425.6 ETO05174.1 - 0.0011 17.8 1.5 0.0016 17.3 1.5 1.1 1 0 0 1 1 1 1 O-antigen ligase like membrane protein DUF4131 PF13567.6 ETO05174.1 - 0.0037 16.9 0.1 0.0061 16.2 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) EXS PF03124.14 ETO05174.1 - 0.018 14.4 3.1 0.028 13.8 3.1 1.2 1 0 0 1 1 1 0 EXS family Reticulon PF02453.17 ETO05174.1 - 0.04 13.9 5.2 0.087 12.8 4.0 2.0 2 1 0 2 2 2 0 Reticulon DUF1465 PF07323.12 ETO05174.1 - 0.16 11.8 4.1 0.12 12.2 2.0 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) Exonuc_VII_L PF02601.15 ETO05174.1 - 0.36 10.3 6.8 0.49 9.9 6.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HemY_N PF07219.13 ETO05174.1 - 0.81 9.9 2.4 0.56 10.4 0.1 2.0 1 1 1 2 2 2 0 HemY protein N-terminus AAA_13 PF13166.6 ETO05176.1 - 0.21 10.2 6.5 0.24 10.0 6.5 1.0 1 0 0 1 1 1 0 AAA domain Trypan_glycop_C PF10659.9 ETO05176.1 - 0.36 11.2 7.8 0.48 10.8 7.8 1.1 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein C-terminal domain DUF1115 PF06544.12 ETO05176.1 - 0.88 9.7 6.7 1 9.5 6.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) Tom22 PF04281.13 ETO05176.1 - 0.9 9.3 8.3 1.1 9.1 8.3 1.1 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 COPI_C PF06957.11 ETO05176.1 - 7.6 5.2 7.7 8.3 5.1 7.7 1.0 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus WD40 PF00400.32 ETO05177.1 - 4.3e-26 90.6 8.7 3.2e-07 30.9 0.1 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05177.1 - 0.0039 17.4 0.2 0.45 10.9 0.0 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05177.1 - 0.018 13.7 0.2 1.4 7.5 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO05177.1 - 0.083 11.6 0.1 1.3 7.7 0.1 2.0 2 0 0 2 2 2 0 Nup133 N terminal like rve PF00665.26 ETO05178.1 - 5.5e-24 84.6 0.0 8.1e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 ETO05178.1 - 0.00046 19.9 0.0 0.0011 18.8 0.0 1.7 1 0 0 1 1 1 1 Integrase core domain MLVIN_C PF18697.1 ETO05178.1 - 0.0091 16.1 0.0 0.022 14.8 0.0 1.7 1 0 0 1 1 1 1 Murine leukemia virus (MLV) integrase (IN) C-terminal domain DDE_Tnp_IS240 PF13610.6 ETO05178.1 - 0.016 15.5 0.0 0.034 14.4 0.0 1.5 1 0 0 1 1 1 0 DDE domain EELM2 PF15863.5 ETO05178.1 - 0.1 12.7 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Extended EGL-27 and MTA1 homology domain NACHT PF05729.12 ETO05179.1 - 1.4e-11 44.6 0.1 3.5e-10 40.0 0.0 2.5 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ETO05179.1 - 9.3e-05 22.7 0.1 0.00061 20.1 0.1 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO05179.1 - 0.0036 17.8 0.0 0.0036 17.8 0.0 3.2 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.14 ETO05179.1 - 0.038 14.0 0.0 9.4 6.2 0.0 3.4 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ETO05179.1 - 0.1 12.5 4.6 0.1 12.5 0.0 3.1 3 0 0 3 3 3 0 RsgA GTPase RNA_helicase PF00910.22 ETO05179.1 - 1.7 9.0 6.8 0.4 11.1 0.1 3.5 3 1 0 3 3 3 0 RNA helicase WD40 PF00400.32 ETO05180.1 - 2.3e-128 414.3 52.5 1.3e-11 44.9 0.2 14.3 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05180.1 - 7.4e-40 135.2 8.3 0.002 18.4 0.0 12.4 1 1 13 14 14 14 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05180.1 - 1.8e-27 96.2 15.1 0.0061 15.6 0.0 12.3 1 1 11 12 12 12 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05180.1 - 3.9e-13 49.4 1.2 0.013 14.8 0.1 6.2 3 1 3 7 7 7 4 WD40-like domain PD40 PF07676.12 ETO05180.1 - 4e-10 39.4 14.1 2.6 8.1 0.0 11.0 12 0 0 12 12 11 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO05180.1 - 6.6e-10 38.3 22.7 0.13 10.8 0.1 10.3 4 3 8 12 12 12 4 Nucleoporin Nup120/160 DUF727 PF05303.12 ETO05180.1 - 9.1e-08 32.1 1.5 6.9 6.8 0.0 7.3 4 3 4 8 8 8 1 Protein of unknown function (DUF727) HARP PF07443.13 ETO05180.1 - 5.3e-06 26.0 0.1 13 5.5 0.0 7.3 10 0 0 10 10 10 0 HepA-related protein (HARP) TolB_N PF04052.13 ETO05180.1 - 8.3e-06 25.9 0.0 46 4.2 0.0 7.9 9 0 0 9 9 9 0 TolB amino-terminal domain Cytochrom_D1 PF02239.16 ETO05180.1 - 8.7e-06 24.5 3.8 3 6.3 0.0 5.2 3 2 1 5 5 5 2 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO05180.1 - 2.5e-05 23.8 4.1 0.0028 17.3 2.9 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) USP7_C2 PF14533.6 ETO05180.1 - 0.00088 19.0 0.0 9.6 5.8 0.0 5.1 3 2 2 6 6 6 0 Ubiquitin-specific protease C-terminal Frtz PF11768.8 ETO05180.1 - 0.0011 17.4 0.1 3.9 5.7 0.1 4.2 2 2 2 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz Pentapeptide_4 PF13599.6 ETO05180.1 - 0.0032 17.6 0.1 0.012 15.8 0.1 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO05180.1 - 0.0035 17.5 1.0 0.025 14.7 1.0 2.4 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Peptidase_C6 PF00851.18 ETO05180.1 - 0.05 12.5 0.1 3.5 6.4 0.0 3.3 3 1 0 4 4 4 0 Helper component proteinase TnpW PF14202.6 ETO05180.1 - 0.086 12.7 4.7 17 5.3 0.0 4.6 5 0 0 5 5 5 0 Transposon-encoded protein TnpW DUF5570 PF17731.1 ETO05180.1 - 0.27 11.3 23.0 5.8 7.0 0.3 8.3 3 3 6 9 9 9 0 Family of unknown function (DUF5570) GCV_T_C PF08669.11 ETO05180.1 - 0.55 10.2 1.9 36 4.4 0.1 3.4 3 1 0 3 3 3 0 Glycine cleavage T-protein C-terminal barrel domain Metallophos PF00149.28 ETO05181.1 - 1.4e-22 81.2 0.0 1.8e-22 80.8 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_5 PF13854.6 ETO05183.1 - 0.0029 17.6 0.1 0.31 11.1 0.0 2.4 1 1 1 2 2 2 2 Kelch motif NACHT PF05729.12 ETO05184.1 - 0.035 14.0 0.0 0.044 13.7 0.0 1.2 1 1 0 1 1 1 0 NACHT domain Tctex-1 PF03645.13 ETO05184.1 - 0.15 12.3 1.1 1.6 9.0 0.1 2.0 2 0 0 2 2 2 0 Tctex-1 family HECT PF00632.25 ETO05185.1 - 4.5e-50 170.9 0.0 5.8e-50 170.5 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Cytidylate_kin2 PF13189.6 ETO05186.1 - 0.019 15.1 0.4 0.12 12.5 0.4 2.4 1 0 0 1 1 1 0 Cytidylate kinase-like family DUF211 PF02680.14 ETO05187.1 - 0.087 13.0 0.1 22 5.3 0.0 2.9 2 0 0 2 2 2 0 Uncharacterized ArCR, COG1888 PMSR PF01625.21 ETO05187.1 - 0.16 12.1 0.8 0.54 10.4 0.0 2.3 2 0 0 2 2 2 0 Peptide methionine sulfoxide reductase MbeD_MobD PF04899.12 ETO05187.1 - 0.72 10.0 6.8 0.17 12.0 0.5 3.3 3 1 1 4 4 4 0 MbeD/MobD like PilJ PF13675.6 ETO05187.1 - 0.93 9.5 3.3 3.6 7.7 0.5 3.4 2 1 1 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term AAA PF00004.29 ETO05189.1 - 1.5e-09 38.4 6.5 0.0051 17.2 0.0 4.1 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO05189.1 - 6.6e-08 32.9 0.0 0.007 16.6 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 ETO05189.1 - 3.7e-07 29.8 0.1 0.00067 19.2 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO05189.1 - 4.4e-07 30.0 2.8 0.0019 18.2 0.9 4.1 2 2 0 2 2 2 2 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO05189.1 - 5.7e-06 26.9 1.5 2.7e-05 24.7 0.7 2.4 2 0 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ETO05189.1 - 8.4e-05 22.5 0.1 8.4e-05 22.5 0.1 2.6 3 0 0 3 3 2 1 RsgA GTPase AAA_16 PF13191.6 ETO05189.1 - 0.00021 21.7 0.0 0.017 15.5 0.0 3.0 2 1 1 3 3 3 1 AAA ATPase domain AAA_8 PF12780.7 ETO05189.1 - 0.00042 19.7 1.4 0.0017 17.8 1.3 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 MCM PF00493.23 ETO05189.1 - 0.00061 18.9 0.3 0.3 10.1 0.1 3.1 3 0 0 3 3 2 1 MCM P-loop domain DUF815 PF05673.13 ETO05189.1 - 0.0048 16.1 0.0 0.0048 16.1 0.0 2.1 2 0 0 2 2 1 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ETO05189.1 - 0.0055 16.5 0.1 0.042 13.6 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation ATPase_2 PF01637.18 ETO05189.1 - 0.008 16.1 18.3 0.025 14.5 12.5 3.4 3 1 0 3 3 2 1 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ETO05189.1 - 0.0091 16.4 0.7 0.33 11.3 0.0 3.5 4 0 0 4 4 3 1 RNA helicase TsaE PF02367.17 ETO05189.1 - 0.01 15.8 0.1 0.051 13.6 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 ETO05189.1 - 0.029 14.4 11.6 3.3 7.7 3.2 4.1 3 1 0 4 4 4 0 AAA domain IstB_IS21 PF01695.17 ETO05189.1 - 0.031 14.0 0.0 2.8 7.6 0.0 3.2 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_18 PF13238.6 ETO05189.1 - 0.035 14.7 7.0 0.54 10.8 6.7 3.1 2 1 0 2 2 2 0 AAA domain CENP-N PF05238.13 ETO05189.1 - 0.037 13.3 4.7 0.089 12.1 4.7 1.6 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Sigma54_activ_2 PF14532.6 ETO05189.1 - 0.042 14.0 0.0 0.55 10.3 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 ETO05189.1 - 0.054 13.4 0.0 9.6 6.1 0.0 3.7 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ETO05189.1 - 0.064 13.5 7.8 24 5.1 6.7 4.0 3 1 0 3 3 2 0 AAA domain Presenilin PF01080.17 ETO05189.1 - 0.072 11.8 2.0 0.12 11.1 2.0 1.4 1 0 0 1 1 1 0 Presenilin NACHT PF05729.12 ETO05189.1 - 0.072 13.0 0.2 0.47 10.3 0.1 2.5 3 0 0 3 3 2 0 NACHT domain Sigma54_activat PF00158.26 ETO05189.1 - 0.085 12.5 0.1 1.5 8.5 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 ETO05189.1 - 0.094 12.1 0.2 13 5.1 0.0 3.3 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI DUF2252 PF10009.9 ETO05189.1 - 0.12 11.4 7.0 0.077 12.0 3.9 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) CDC45 PF02724.14 ETO05189.1 - 0.17 10.2 8.0 0.28 9.4 8.0 1.3 1 0 0 1 1 1 0 CDC45-like protein AAA_30 PF13604.6 ETO05189.1 - 0.17 11.6 0.0 23 4.6 0.0 2.7 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETO05189.1 - 0.28 10.7 0.8 9.5 5.7 0.0 3.3 4 0 0 4 4 3 0 AAA domain Viral_helicase1 PF01443.18 ETO05189.1 - 0.35 10.6 1.8 4.4 7.0 0.0 2.7 3 0 0 3 3 2 0 Viral (Superfamily 1) RNA helicase CobA_CobO_BtuR PF02572.15 ETO05189.1 - 0.38 11.0 8.0 0.6 10.3 2.4 3.0 3 1 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP PPL5 PF18168.1 ETO05189.1 - 0.6 9.3 5.8 1.3 8.3 5.8 1.5 1 0 0 1 1 1 0 Prim-pol family 5 AAA_19 PF13245.6 ETO05189.1 - 6.9 7.0 9.4 55 4.1 4.1 3.8 2 2 0 2 2 2 0 AAA domain ATP13 PF12921.7 ETO05190.1 - 0.0097 15.8 0.2 0.046 13.6 0.2 2.2 1 0 0 1 1 1 1 Mitochondrial ATPase expression Lzipper-MIP1 PF14389.6 ETO05190.1 - 0.034 14.5 0.1 29 5.1 0.0 3.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 MinC_N PF05209.13 ETO05190.1 - 0.041 13.8 0.1 0.2 11.6 0.0 2.2 2 0 0 2 2 2 0 Septum formation inhibitor MinC, N-terminal domain PapC_N PF13954.6 ETO05190.1 - 0.054 13.5 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 PapC N-terminal domain MTTB PF06253.11 ETO05190.1 - 0.32 8.9 0.8 0.52 8.2 0.8 1.2 1 0 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) ubiquitin PF00240.23 ETO05191.1 - 4.4e-50 167.3 2.5 6.6e-27 93.1 0.2 2.3 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETO05191.1 - 2e-23 82.0 1.0 1.8e-11 43.7 0.1 2.4 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO05191.1 - 5e-11 42.9 0.3 0.00035 21.0 0.1 2.9 2 1 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO05191.1 - 2.1e-10 40.4 1.0 0.00069 19.5 0.0 3.1 2 1 1 3 3 3 2 TANK binding kinase 1 ubiquitin-like domain DUF2407 PF10302.9 ETO05191.1 - 1.2e-05 25.9 0.0 0.23 12.0 0.0 2.5 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO05191.1 - 0.0018 18.4 4.6 0.31 11.2 0.0 3.4 2 1 1 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO05191.1 - 0.0036 17.6 5.3 0.069 13.5 0.1 3.1 2 1 1 3 3 3 1 Ubiquitin-like domain RBD PF02196.15 ETO05191.1 - 0.022 14.8 0.2 8.1 6.6 0.0 2.9 3 0 0 3 3 3 0 Raf-like Ras-binding domain UN_NPL4 PF11543.8 ETO05191.1 - 0.087 13.3 0.5 14 6.3 0.0 2.7 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 GHD PF17834.1 ETO05191.1 - 0.13 12.3 2.8 4.5 7.4 0.3 2.4 1 1 1 2 2 2 0 Beta-sandwich domain in beta galactosidase Pox_A28 PF04584.14 ETO05191.1 - 0.17 12.0 4.0 1.6 8.9 1.4 2.8 2 1 1 3 3 3 0 Poxvirus A28 family Hid1 PF12722.7 ETO05192.1 - 0.41 8.7 7.9 0.46 8.5 7.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RNA_pol_Rpc4 PF05132.14 ETO05192.1 - 1.3 9.4 12.4 14 6.1 12.4 2.0 1 1 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETO05192.1 - 2 7.1 9.5 2.5 6.8 9.5 1.3 1 0 0 1 1 1 0 Presenilin UBA_4 PF14555.6 ETO05193.1 - 3.2e-12 46.0 0.2 6.7e-12 45.0 0.2 1.6 1 0 0 1 1 1 1 UBA-like domain UBX PF00789.20 ETO05193.1 - 9e-08 32.2 0.0 2.5e-07 30.8 0.0 1.8 1 0 0 1 1 1 1 UBX domain GA PF01468.17 ETO05193.1 - 0.11 12.8 2.7 0.29 11.5 2.7 1.8 1 0 0 1 1 1 0 GA module MMgT PF10270.9 ETO05194.1 - 1.8e-05 25.0 0.1 2.4e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 Membrane magnesium transporter WD40 PF00400.32 ETO05195.1 - 1.8e-07 31.7 2.8 0.0098 16.7 0.2 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Bact_lectin PF18483.1 ETO05195.1 - 0.051 13.6 0.0 0.1 12.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial lectin Atx10homo_assoc PF09759.9 ETO05196.1 - 2.7e-08 33.7 6.7 3.8e-07 30.0 1.1 3.0 3 0 0 3 3 3 2 Spinocerebellar ataxia type 10 protein domain WAPL PF07814.13 ETO05196.1 - 1e-05 24.5 3.3 1.4e-05 24.0 3.3 1.3 1 0 0 1 1 1 1 Wings apart-like protein regulation of heterochromatin DUF5578 PF17741.1 ETO05196.1 - 5.7e-05 22.7 1.8 0.00019 21.0 1.8 1.9 1 1 0 1 1 1 1 Family of unknown function (DUF5578) DUF3361 PF11841.8 ETO05196.1 - 8.8e-05 22.5 2.3 0.00033 20.6 0.4 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) Neurochondrin PF05536.11 ETO05196.1 - 0.00054 18.5 2.5 0.039 12.3 0.5 2.0 2 0 0 2 2 2 2 Neurochondrin Arm_2 PF04826.13 ETO05196.1 - 0.0013 18.2 7.1 0.0031 17.0 0.1 2.1 1 1 1 2 2 2 1 Armadillo-like V-ATPase_H_N PF03224.14 ETO05196.1 - 0.011 15.1 0.3 0.021 14.1 0.3 1.5 1 1 0 1 1 1 0 V-ATPase subunit H RsmJ PF04378.13 ETO05196.1 - 0.13 11.5 0.0 0.27 10.4 0.0 1.5 1 1 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ Tubulin_C PF03953.17 ETO05197.1 - 2.7e-19 69.6 0.1 5.6e-19 68.5 0.1 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain WD40 PF00400.32 ETO05198.1 - 3.7e-135 435.8 46.7 3.1e-10 40.5 0.2 16.4 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05198.1 - 4.4e-34 116.6 14.8 0.0036 17.6 0.5 13.2 1 1 12 14 14 14 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05198.1 - 1e-20 74.0 10.5 0.21 10.5 0.0 12.6 1 1 8 11 11 11 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05198.1 - 8.2e-16 58.2 15.0 4.5e-05 22.9 0.0 8.3 3 2 5 10 10 10 4 WD40-like domain Pentapeptide PF00805.22 ETO05198.1 - 8.5e-09 34.9 2.0 2.2e-08 33.6 2.0 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO05198.1 - 9.4e-07 28.9 2.9 4.7 7.4 0.0 9.0 9 2 1 11 11 11 1 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO05198.1 - 2.7e-06 27.4 0.3 8.5e-06 25.8 0.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO05198.1 - 5.1e-06 26.3 22.9 9.5 6.3 0.0 10.8 12 0 0 12 12 12 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO05198.1 - 6.1e-06 25.8 13.1 3.9 6.7 0.3 8.3 4 3 6 10 10 10 3 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO05198.1 - 2.7e-05 22.9 4.4 0.36 9.3 0.0 4.6 2 2 1 4 4 4 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO05198.1 - 6.2e-05 23.1 16.6 1.9 8.6 0.1 8.9 4 3 7 11 11 11 1 Family of unknown function (DUF5570) Pentapeptide_3 PF13576.6 ETO05198.1 - 0.00041 20.4 0.4 0.0013 18.8 0.4 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) SUI1 PF01253.22 ETO05199.1 - 9e-22 77.4 0.0 2.2e-21 76.2 0.0 1.7 1 0 0 1 1 1 1 Translation initiation factor SUI1 SWIB PF02201.18 ETO05199.1 - 4e-05 23.4 0.1 0.00016 21.5 0.1 2.1 1 0 0 1 1 1 1 SWIB/MDM2 domain SUIM_assoc PF16619.5 ETO05199.1 - 0.0032 17.5 4.9 0.0074 16.3 4.9 1.7 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Folliculin PF11704.8 ETO05199.1 - 0.033 14.1 0.9 0.054 13.4 0.9 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Spt20 PF12090.8 ETO05199.1 - 0.68 9.5 13.8 1.2 8.7 13.8 1.4 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 ETO05199.1 - 1.3 7.9 11.7 1.9 7.3 11.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Peptidase_S10 PF00450.22 ETO05200.1 - 4.9e-67 227.1 8.3 5.7e-67 226.9 8.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Hydrolase_6 PF13344.6 ETO05201.1 - 1.5e-24 86.0 0.1 2.7e-24 85.2 0.1 1.5 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETO05201.1 - 3.3e-20 71.9 0.0 6.5e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ETO05201.1 - 7.3e-10 39.5 0.5 0.0037 17.6 0.0 3.1 2 1 1 3 3 3 3 haloacid dehalogenase-like hydrolase HAD_2 PF13419.6 ETO05201.1 - 9.3e-09 35.6 0.9 0.0014 18.7 0.0 2.9 2 1 1 3 3 3 2 Haloacid dehalogenase-like hydrolase PGP_phosphatase PF09419.10 ETO05201.1 - 0.042 13.5 0.1 0.8 9.3 0.0 2.4 2 1 0 2 2 2 0 Mitochondrial PGP phosphatase Atypical_Card PF18461.1 ETO05204.1 - 0.061 13.5 2.2 0.19 12.0 0.4 2.9 2 0 0 2 2 2 0 Atypical caspase recruitment domain DUF5343 PF17278.2 ETO05204.1 - 0.088 12.9 0.9 0.42 10.7 0.9 2.2 1 0 0 1 1 1 0 Family of unknown function (DUF5343) Imm-NTF2 PF15655.6 ETO05204.1 - 0.11 12.8 8.4 13 6.1 1.3 4.4 4 0 0 4 4 4 0 NTF2 fold immunity protein Ank_4 PF13637.6 ETO05206.1 - 0.0002 21.8 0.6 0.00072 20.1 0.6 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO05206.1 - 0.01 16.4 0.1 0.032 14.8 0.1 1.9 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Peptidase_M1 PF01433.20 ETO05207.1 - 4.1e-07 29.8 2.0 4.1e-07 29.8 2.0 2.0 2 0 0 2 2 2 1 Peptidase family M1 domain MA3 PF02847.17 ETO05207.1 - 0.025 14.6 5.2 1.9 8.5 0.3 3.4 3 0 0 3 3 3 0 MA3 domain DUF3915 PF13054.6 ETO05207.1 - 0.035 14.1 8.5 0.06 13.3 7.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 ETO05207.1 - 0.12 10.6 9.5 0.18 10.1 9.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Sacchrp_dh_NADP PF03435.18 ETO05208.1 - 1.4e-33 115.9 0.0 2.7e-33 115.0 0.0 1.4 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Sacchrp_dh_C PF16653.5 ETO05208.1 - 9.6e-28 98.0 0.0 1.6e-27 97.3 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Aa_trans PF01490.18 ETO05209.1 - 3.9e-05 22.5 11.4 5.8e-05 22.0 2.9 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ETO05209.1 - 0.00022 20.4 0.7 0.00022 20.4 0.7 1.9 1 1 0 2 2 2 1 Tryptophan/tyrosine permease family Flu_NP PF00506.18 ETO05212.1 - 0.0085 14.8 1.4 0.012 14.3 1.4 1.1 1 0 0 1 1 1 1 Influenza virus nucleoprotein Kelch_4 PF13418.6 ETO05213.1 - 2.9e-06 27.2 0.1 0.0018 18.3 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO05213.1 - 4.3e-05 23.6 1.7 0.0053 17.0 0.1 3.1 1 1 2 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO05213.1 - 0.0054 16.7 0.4 0.81 9.7 0.4 2.6 2 1 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO05213.1 - 0.014 15.0 0.2 0.61 9.7 0.2 2.8 2 1 1 3 3 3 0 Kelch motif Anoctamin PF04547.12 ETO05214.1 - 1.7e-41 142.5 21.0 6.5e-37 127.4 9.7 2.0 1 1 1 2 2 2 2 Calcium-activated chloride channel ECF_trnsprt PF12822.7 ETO05214.1 - 0.0018 18.4 4.7 0.0018 18.4 4.7 2.4 2 1 0 2 2 2 1 ECF transporter, substrate-specific component Kelch_6 PF13964.6 ETO05215.1 - 0.00083 19.6 0.0 1.2 9.6 0.0 3.0 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO05215.1 - 0.031 14.3 0.2 7.3 6.7 0.0 3.5 4 0 0 4 4 4 0 Kelch motif Hydrolase_3 PF08282.12 ETO05215.1 - 0.045 13.5 4.8 0.024 14.4 1.5 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase U-box PF04564.15 ETO05219.1 - 4e-12 46.1 0.0 7.9e-12 45.2 0.0 1.5 1 0 0 1 1 1 1 U-box domain Ig_5 PF16681.5 ETO05220.1 - 0.044 14.2 1.5 0.096 13.1 1.5 1.6 1 0 0 1 1 1 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF5564 PF17719.1 ETO05221.1 - 0.026 14.6 0.3 12 6.2 0.0 2.5 1 1 1 2 2 2 0 Family of unknown function (DUF5564) zf-TRAF PF02176.18 ETO05222.1 - 2.8e-05 24.7 3.9 2.8e-05 24.7 3.9 2.3 3 1 0 3 3 3 1 TRAF-type zinc finger Sina PF03145.16 ETO05222.1 - 0.00052 20.0 4.1 0.0011 18.9 4.1 1.6 1 1 0 1 1 1 1 Seven in absentia protein family zf-C3HC4_2 PF13923.6 ETO05222.1 - 0.014 15.2 1.3 0.25 11.2 0.1 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO05222.1 - 0.54 10.6 0.1 0.54 10.6 0.1 2.9 2 1 1 3 3 3 0 Ring finger domain WD40 PF00400.32 ETO05223.1 - 9.6e-07 29.4 5.3 4.9e-05 24.0 0.8 2.5 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05223.1 - 0.00058 20.1 0.1 1.1 9.7 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO05225.1 - 2.1e-07 31.5 2.2 1.7e-05 25.5 0.7 2.8 2 2 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO05225.1 - 0.098 11.3 0.0 0.11 11.1 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Glycos_transf_2 PF00535.26 ETO05227.1 - 7.3e-13 48.7 0.0 5.7e-10 39.3 0.0 2.6 2 0 0 2 2 2 2 Glycosyl transferase family 2 DUF202 PF02656.15 ETO05227.1 - 8.4e-09 35.7 1.7 8.4e-09 35.7 1.7 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF202) SPX PF03105.19 ETO05227.1 - 5.5e-05 23.3 0.0 0.00013 22.0 0.0 1.6 1 0 0 1 1 1 1 SPX domain SUIM_assoc PF16619.5 ETO05227.1 - 0.059 13.4 0.4 3.3 7.8 0.0 2.9 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Ras PF00071.22 ETO05228.1 - 0.026 14.1 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 Ras family QueF PF14489.6 ETO05229.1 - 0.13 12.5 0.1 0.34 11.1 0.1 1.7 1 0 0 1 1 1 0 QueF-like protein Peptidase_C14 PF00656.22 ETO05230.1 - 0.0024 17.9 1.6 0.0027 17.7 0.1 1.8 2 0 0 2 2 2 1 Caspase domain Telomerase_RBD PF12009.8 ETO05230.1 - 0.82 9.8 9.2 4.9 7.3 2.4 2.2 1 1 1 2 2 2 0 Telomerase ribonucleoprotein complex - RNA binding domain AP3D1 PF06375.11 ETO05231.1 - 3.6 7.8 13.7 31 4.8 15.7 1.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 SR-25 PF10500.9 ETO05231.1 - 5.9 6.4 15.7 7.9 6.0 15.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FBPase PF00316.20 ETO05232.1 - 4.4e-65 218.7 0.0 5.9e-65 218.3 0.0 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 ETO05232.1 - 0.062 12.8 0.0 0.23 10.9 0.0 1.9 2 0 0 2 2 2 0 Inositol monophosphatase family POR_N PF01855.19 ETO05233.1 - 0.033 13.9 2.7 0.076 12.7 2.0 1.9 1 1 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg YqgF PF14639.6 ETO05233.1 - 5.3 6.8 8.4 18 5.1 0.3 2.9 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 Vfa1 PF08432.10 ETO05234.1 - 9 6.6 23.7 6.3 7.1 12.8 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 WD40 PF00400.32 ETO05236.1 - 2.9e-60 198.8 13.3 2.6e-09 37.5 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05236.1 - 1.6e-18 66.8 1.8 0.018 15.3 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05236.1 - 1.4e-11 44.3 2.8 7.6e-05 22.2 0.1 3.6 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO05236.1 - 1.5e-08 33.8 1.6 0.42 9.2 0.0 5.7 3 1 3 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO05236.1 - 0.0052 15.4 2.6 0.82 8.1 0.0 3.2 3 1 0 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO05236.1 - 0.011 14.6 0.6 11 4.8 0.0 3.5 1 1 3 4 4 4 0 Partner and localizer of BRCA2 WD40 domain BBS2_Mid PF14783.6 ETO05236.1 - 0.014 15.4 5.7 2.2 8.3 0.2 5.2 3 2 2 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 ETO05236.1 - 0.052 12.3 10.9 0.98 8.1 3.4 3.8 1 1 0 3 3 3 0 Nup133 N terminal like Pkinase PF00069.25 ETO05237.1 - 1.4e-71 240.9 0.1 1e-54 185.7 0.2 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05237.1 - 3.4e-39 134.7 0.1 3.8e-32 111.6 0.2 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO05237.1 - 2.2e-05 24.0 0.0 0.013 14.9 0.0 2.4 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ETO05237.1 - 3.6e-05 22.7 2.9 6.8e-05 21.8 2.9 1.6 1 1 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO05237.1 - 7.7e-05 21.8 0.6 0.00035 19.6 0.6 2.0 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETO05237.1 - 0.00091 18.6 1.2 0.0017 17.8 1.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO05237.1 - 0.013 15.5 0.3 0.084 12.8 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family BST2 PF16716.5 ETO05239.1 - 0.002 18.7 0.6 0.0061 17.1 0.6 1.8 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 Bcr-Abl_Oligo PF09036.10 ETO05239.1 - 0.052 13.5 0.3 0.11 12.5 0.3 1.6 1 1 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain AfaD PF05775.12 ETO05239.1 - 0.13 12.7 0.0 0.21 12.0 0.0 1.3 1 0 0 1 1 1 0 Enterobacteria AfaD invasin protein DUF4337 PF14235.6 ETO05240.1 - 0.097 12.8 3.7 0.2 11.8 3.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) ATG2_CAD PF13329.6 ETO05240.1 - 0.12 12.1 1.7 1.2 8.8 0.6 2.3 1 1 1 2 2 2 0 Autophagy-related protein 2 CAD motif DUF724 PF05266.14 ETO05240.1 - 0.58 10.0 8.1 0.95 9.3 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 ETO05240.1 - 1.5 8.1 4.3 2 7.7 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3523 PF12037.8 ETO05240.1 - 3.8 6.8 13.6 5.9 6.2 13.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Ferric_reduct PF01794.19 ETO05243.1 - 3e-18 66.1 9.8 5.2e-18 65.4 9.8 1.4 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ETO05243.1 - 3.7e-11 43.1 0.1 6.7e-11 42.2 0.1 1.4 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 ETO05243.1 - 0.0032 17.8 0.0 0.0053 17.1 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ETO05244.1 - 5.2e-12 46.2 0.0 2.4e-11 44.0 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ETO05244.1 - 0.017 15.8 0.1 0.11 13.2 0.0 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain NST1 PF13945.6 ETO05245.1 - 0.27 11.3 19.7 0.65 10.1 19.7 1.7 1 0 0 1 1 1 0 Salt tolerance down-regulator Neur_chan_memb PF02932.16 ETO05245.1 - 0.67 10.0 9.7 0.5 10.4 7.7 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO05245.1 - 2.3 6.4 19.5 3.4 5.8 19.0 1.5 2 0 0 2 2 2 0 CDC45-like protein PNISR PF15996.5 ETO05245.1 - 9.8 6.4 21.2 0.26 11.5 14.9 1.5 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR DUF4407 PF14362.6 ETO05246.1 - 1.4 8.2 5.7 1.5 8.1 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) BRICHOS PF04089.14 ETO05246.1 - 1.6 9.0 6.0 6.1 7.2 6.0 1.9 1 1 0 1 1 1 0 BRICHOS domain Miga PF10265.9 ETO05247.1 - 0.28 10.1 10.0 0.33 9.9 10.0 1.1 1 0 0 1 1 1 0 Mitoguardin Presenilin PF01080.17 ETO05247.1 - 9.1 4.9 7.2 10 4.8 7.2 1.1 1 0 0 1 1 1 0 Presenilin zf-TRAF PF02176.18 ETO05248.1 - 5.3e-06 27.0 3.6 5.3e-06 27.0 3.6 3.1 3 1 0 3 3 3 1 TRAF-type zinc finger zf-RING_2 PF13639.6 ETO05248.1 - 0.027 14.8 1.1 0.027 14.8 1.1 3.1 3 1 0 3 3 3 0 Ring finger domain Glu_cyclase_2 PF05096.12 ETO05249.1 - 0.066 12.6 0.1 0.097 12.1 0.1 1.3 1 0 0 1 1 1 0 Glutamine cyclotransferase TPR_12 PF13424.6 ETO05250.1 - 9.7e-43 144.4 13.1 1.2e-11 44.7 0.1 4.5 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05250.1 - 1.9e-24 84.4 33.7 6.8e-07 28.8 2.7 7.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO05250.1 - 1.2e-21 75.9 5.4 2.7e-06 27.1 0.1 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05250.1 - 1.2e-19 68.8 20.6 0.00085 19.3 0.1 6.8 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05250.1 - 1.2e-18 65.7 28.1 0.0016 18.5 1.1 7.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05250.1 - 2.4e-18 64.8 3.3 0.00019 21.2 0.1 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO05250.1 - 2.2e-07 31.0 4.6 4.4 8.2 0.2 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO05250.1 - 4.5e-07 29.8 4.0 0.49 10.9 0.2 6.6 7 0 0 7 7 7 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO05250.1 - 4.7e-05 23.5 2.2 0.002 18.2 2.2 2.4 1 1 0 1 1 1 1 Caspase domain SPO22 PF08631.10 ETO05250.1 - 0.025 14.1 6.5 0.29 10.6 4.2 2.6 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETO05250.1 - 0.14 12.2 8.7 3.1 7.9 0.3 4.5 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain DUF4810 PF16068.5 ETO05250.1 - 0.15 12.6 7.5 12 6.5 0.2 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF4810) TPR_11 PF13414.6 ETO05250.1 - 1.2 8.9 20.0 3.2 7.5 0.4 6.6 6 2 1 7 7 7 0 TPR repeat PET122 PF05476.11 ETO05251.1 - 0.0034 16.7 0.8 0.004 16.5 0.8 1.2 1 0 0 1 1 1 1 PET122 WD40 PF00400.32 ETO05252.1 - 9.3e-58 190.9 17.5 8.9e-12 45.3 0.1 6.4 7 0 0 7 7 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05252.1 - 9.2e-19 67.5 3.9 0.042 14.1 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05252.1 - 2.9e-10 40.0 0.1 0.00015 21.2 0.0 3.3 3 0 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO05252.1 - 8.4e-10 38.1 0.1 0.051 12.5 0.0 5.5 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05252.1 - 2.3e-09 36.5 2.3 0.39 9.3 0.0 5.5 3 3 3 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO05252.1 - 4e-08 33.4 0.2 2.3e-05 24.4 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO05252.1 - 3.2e-05 22.6 0.6 0.02 13.4 0.1 3.3 1 1 3 4 4 4 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO05252.1 - 0.00046 19.1 4.9 0.37 9.5 0.4 4.2 1 1 4 5 5 5 1 Nup133 N terminal like Nbas_N PF15492.6 ETO05252.1 - 0.0082 15.5 1.9 1.9 7.8 0.1 3.4 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO05252.1 - 0.014 14.5 0.0 0.042 12.9 0.0 2.0 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain DUF1797 PF08796.10 ETO05252.1 - 0.015 15.4 0.0 3.5 7.8 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1797) Coatomer_WDAD PF04053.14 ETO05252.1 - 0.015 14.4 0.3 0.062 12.3 0.1 2.1 1 1 0 1 1 1 0 Coatomer WD associated region DUF5474 PF17568.2 ETO05252.1 - 0.015 15.3 0.0 5.7 7.1 0.0 2.8 3 0 0 3 3 2 0 Family of unknown function (DUF5474) BBS2_Mid PF14783.6 ETO05252.1 - 0.036 14.1 2.4 1.6 8.8 0.2 4.0 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region HARP PF07443.13 ETO05252.1 - 0.077 12.6 0.2 2.9 7.6 0.0 3.3 3 0 0 3 3 3 0 HepA-related protein (HARP) DUF727 PF05303.12 ETO05252.1 - 0.088 12.9 0.0 17 5.5 0.0 3.2 2 2 1 3 3 3 0 Protein of unknown function (DUF727) PD40 PF07676.12 ETO05252.1 - 0.28 11.2 5.4 25 4.9 0.1 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO05253.1 - 4.9e-36 122.1 7.8 4.1e-11 43.2 0.3 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05253.1 - 9.4e-11 41.9 0.2 9.3e-05 22.7 0.0 3.5 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05253.1 - 2.6e-07 29.9 0.3 0.095 11.6 0.1 3.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05253.1 - 4.6e-05 22.9 0.0 0.0091 15.3 0.0 2.2 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO05253.1 - 0.00027 19.7 3.3 0.03 13.0 0.1 3.1 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF727 PF05303.12 ETO05253.1 - 0.0038 17.3 0.0 0.11 12.6 0.0 2.3 1 1 0 2 2 2 1 Protein of unknown function (DUF727) Frtz PF11768.8 ETO05253.1 - 0.034 12.5 0.0 0.043 12.1 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz TolB_N PF04052.13 ETO05253.1 - 0.069 13.3 0.0 2.7 8.2 0.0 2.4 2 0 0 2 2 2 0 TolB amino-terminal domain NYD-SP28_assoc PF14775.6 ETO05253.1 - 0.18 11.9 1.9 56 4.0 0.0 3.8 4 0 0 4 4 4 0 Sperm tail C-terminal domain adh_short PF00106.25 ETO05254.1 - 3.1e-24 85.5 0.2 7.2e-17 61.5 0.0 2.2 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO05254.1 - 3.3e-17 62.8 0.0 2.5e-10 40.3 0.0 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO05254.1 - 0.00028 20.8 0.0 0.00094 19.1 0.0 1.8 2 0 0 2 2 2 1 KR domain K1377 PF15352.6 ETO05254.1 - 0.083 11.2 0.4 0.13 10.5 0.4 1.2 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy Metallophos PF00149.28 ETO05256.1 - 4.5e-06 27.3 0.0 5.4e-06 27.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO05256.1 - 0.00037 20.7 0.0 0.001 19.3 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain TPR_17 PF13431.6 ETO05257.1 - 9e-06 25.7 1.7 0.0078 16.5 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO05257.1 - 0.00057 20.3 1.8 0.075 13.5 0.9 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05257.1 - 0.013 15.6 6.3 0.027 14.6 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05257.1 - 0.014 15.2 0.1 0.062 13.1 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO05257.1 - 0.015 16.1 0.7 0.082 13.8 0.1 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO05257.1 - 0.68 10.3 4.4 0.76 10.1 0.6 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF748 PF05359.11 ETO05258.1 - 0.084 13.0 1.7 1.9 8.7 0.5 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF748) G8 PF10162.9 ETO05258.1 - 0.097 12.8 0.1 0.17 11.9 0.1 1.5 1 1 0 1 1 1 0 G8 domain CBP4 PF07960.11 ETO05259.1 - 0.013 15.3 0.7 0.013 15.3 0.7 3.6 3 0 0 3 3 3 0 CBP4 HTH_38 PF13936.6 ETO05259.1 - 0.066 13.0 1.3 0.33 10.8 0.7 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain DUF3915 PF13054.6 ETO05259.1 - 7.2 6.6 8.8 1.6 8.7 0.2 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) RDD PF06271.12 ETO05260.1 - 0.17 12.1 9.2 2.3 8.4 3.6 2.3 2 1 0 2 2 2 0 RDD family UPF0242 PF06785.11 ETO05260.1 - 4.8 7.2 6.5 3.2 7.8 4.5 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus RelA_SpoT PF04607.17 ETO05262.1 - 0.0026 18.0 2.1 0.0054 17.0 2.1 1.5 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins RTT107_BRCT_6 PF16771.5 ETO05262.1 - 0.022 14.9 0.4 0.063 13.4 0.4 1.7 1 0 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain zf-ZPR1 PF03367.13 ETO05262.1 - 0.074 12.9 3.9 0.94 9.3 0.0 2.6 1 1 1 2 2 2 0 ZPR1 zinc-finger domain DUF5126 PF17166.4 ETO05262.1 - 0.15 12.0 1.5 0.17 11.8 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5126) SRP54_N PF02881.19 ETO05263.1 - 1.9 8.8 5.5 1 9.6 0.1 2.9 3 0 0 3 3 3 0 SRP54-type protein, helical bundle domain Seryl_tRNA_N PF02403.22 ETO05265.1 - 0.0017 18.5 0.3 0.0044 17.2 0.3 1.8 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain ATG16 PF08614.11 ETO05265.1 - 0.013 15.7 1.7 0.013 15.7 1.7 1.6 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) DUF3019 PF11456.8 ETO05265.1 - 1.4 9.5 8.9 0.21 12.1 1.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3019) EF-hand_7 PF13499.6 ETO05266.1 - 8.4e-07 29.4 2.8 0.0019 18.6 0.1 2.1 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO05266.1 - 2.2e-05 23.7 0.5 2.2e-05 23.7 0.5 2.5 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ETO05266.1 - 0.00091 19.0 0.4 0.00091 19.0 0.4 2.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_8 PF13833.6 ETO05266.1 - 0.0027 17.5 0.4 0.0027 17.5 0.4 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_4 PF12763.7 ETO05266.1 - 0.0061 16.5 0.5 0.013 15.4 0.3 1.6 1 1 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 ETO05266.1 - 0.0078 15.7 0.2 0.0078 15.7 0.2 2.1 3 0 0 3 3 3 1 EF hand Glyco_hydro_38C PF07748.13 ETO05267.1 - 3.8e-21 76.2 0.1 9.1e-21 74.9 0.0 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Alpha-mann_mid PF09261.11 ETO05267.1 - 5.7e-16 58.4 0.1 1.5e-15 57.1 0.1 1.7 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38N PF01074.22 ETO05267.1 - 7.9e-14 51.7 0.8 1.4e-13 50.9 0.2 1.7 2 0 0 2 2 2 1 Glycosyl hydrolases family 38 N-terminal domain Glyco_hydro38C2 PF17677.1 ETO05267.1 - 0.0025 17.9 0.0 0.0083 16.2 0.0 2.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal beta sandwich domain DUF4251 PF14059.6 ETO05267.1 - 0.086 12.8 1.8 0.11 12.5 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4251) Viral_cys_rich PF08008.12 ETO05267.1 - 0.38 10.8 3.4 1.2 9.3 0.2 3.0 3 0 0 3 3 3 0 Viral cysteine rich Pkinase PF00069.25 ETO05268.1 - 4e-34 118.2 0.0 6.4e-33 114.2 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05268.1 - 1.2e-17 64.1 0.0 1.3e-16 60.7 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO05268.1 - 5.9e-05 22.5 0.1 0.1 11.9 0.0 3.1 4 0 0 4 4 4 2 Kinase-like Pox_ser-thr_kin PF05445.11 ETO05268.1 - 0.061 12.3 0.0 0.1 11.6 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Promethin PF16015.5 ETO05268.1 - 0.18 11.7 2.2 0.29 11.1 2.2 1.3 1 0 0 1 1 1 0 Promethin CDC45 PF02724.14 ETO05268.1 - 3.4 5.8 9.0 4.2 5.5 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO05268.1 - 8.3 5.1 14.5 14 4.3 14.5 1.3 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO05269.1 - 2.2e-107 347.9 54.9 1.8e-09 38.1 0.5 16.5 16 0 0 16 16 16 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05269.1 - 3e-26 91.5 13.6 0.018 15.3 0.0 12.9 1 1 14 15 15 15 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05269.1 - 5.4e-17 61.7 6.5 0.35 9.8 0.2 11.2 2 2 9 11 11 11 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO05269.1 - 6.8e-10 39.1 0.0 1.7e-09 37.8 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO05269.1 - 4.3e-07 29.5 2.8 9.9e-07 28.3 2.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO05269.1 - 0.00052 20.1 0.2 0.003 17.7 0.1 2.2 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO05269.1 - 0.00084 19.9 0.0 0.01 16.4 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO05269.1 - 0.0027 18.0 0.0 0.0088 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain Pentapeptide_3 PF13576.6 ETO05269.1 - 0.015 15.4 0.6 0.039 14.1 0.6 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO05269.1 - 0.089 12.9 8.4 2.1 8.5 0.1 5.2 4 3 2 6 6 6 0 Family of unknown function (DUF5570) ABC_tran PF00005.27 ETO05269.1 - 0.11 13.0 2.4 0.81 10.2 0.0 3.1 3 0 0 3 3 2 0 ABC transporter CbiA PF01656.23 ETO05269.1 - 0.13 12.4 0.3 26 4.9 0.1 2.9 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain PD40 PF07676.12 ETO05269.1 - 0.37 10.8 18.8 86 3.2 0.0 8.0 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO05271.1 - 4.1e-62 204.6 21.2 1.1e-08 35.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05271.1 - 5.5e-27 93.9 2.7 0.00032 20.9 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05271.1 - 6.3e-15 55.3 1.2 0.00033 20.1 0.1 4.5 1 1 2 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO05271.1 - 1.2e-10 40.9 0.7 0.24 10.3 0.0 5.9 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05271.1 - 1.5e-10 40.4 7.3 0.15 10.7 0.0 5.4 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO05271.1 - 3.5e-05 22.5 0.1 0.0054 15.3 0.0 2.4 1 1 0 2 2 2 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO05271.1 - 5.3e-05 22.9 0.1 0.00016 21.3 0.1 1.8 1 1 1 2 2 2 1 PQQ-like domain Nucleoporin_N PF08801.11 ETO05271.1 - 0.00062 18.6 10.5 1.2 7.8 0.2 5.3 1 1 4 5 5 5 2 Nup133 N terminal like Utp8 PF10395.9 ETO05271.1 - 0.0022 16.6 0.1 7 5.0 0.1 3.0 1 1 2 3 3 3 2 Utp8 family Nbas_N PF15492.6 ETO05271.1 - 0.0022 17.4 0.9 10 5.4 0.1 3.2 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal ArlS_N PF18719.1 ETO05271.1 - 0.0022 18.2 0.2 0.35 11.1 0.0 3.5 2 1 2 4 4 4 1 ArlS sensor domain Invas_SpaK PF03519.14 ETO05271.1 - 0.0044 17.1 0.5 3.6 7.7 0.1 3.5 2 1 0 2 2 2 1 Invasion protein B family Me-amine-dh_H PF06433.11 ETO05271.1 - 0.0075 15.2 0.0 0.024 13.5 0.0 1.9 1 1 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) PQQ_3 PF13570.6 ETO05271.1 - 0.023 15.2 1.4 6.9 7.3 0.0 4.5 6 1 0 6 6 5 0 PQQ-like domain DUF1797 PF08796.10 ETO05271.1 - 0.025 14.6 0.0 0.99 9.5 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) PD40 PF07676.12 ETO05271.1 - 0.089 12.8 8.0 13 5.9 0.1 5.7 7 0 0 7 7 6 0 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO05271.1 - 0.1 12.7 0.2 2.5 8.3 0.0 3.2 3 1 1 4 4 4 0 Family of unknown function (DUF5474) Big_7 PF17957.1 ETO05271.1 - 0.52 11.1 4.0 1.1 10.1 0.1 3.2 5 0 0 5 5 3 0 Bacterial Ig domain WD40 PF00400.32 ETO05272.1 - 3.4e-15 56.1 4.1 1.6e-05 25.5 0.1 4.6 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05272.1 - 7e-07 29.5 0.2 0.13 12.5 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05272.1 - 3e-05 23.5 3.7 0.014 14.7 0.1 2.8 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO05272.1 - 5.4e-05 22.0 0.3 0.11 11.1 0.1 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO05272.1 - 0.0044 17.0 1.7 2.6 8.1 0.1 3.5 2 2 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF21 PF01595.20 ETO05274.1 - 1.3e-28 99.9 0.1 2e-28 99.3 0.1 1.3 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETO05274.1 - 6.7e-06 26.5 0.6 0.087 13.3 0.0 3.5 4 0 0 4 4 4 2 CBS domain zf-TRAF PF02176.18 ETO05275.1 - 4e-07 30.6 3.2 4e-07 30.6 3.2 2.9 2 1 0 2 2 2 1 TRAF-type zinc finger zf-RING_2 PF13639.6 ETO05275.1 - 0.011 16.0 5.6 0.33 11.3 0.9 3.0 2 0 0 2 2 2 0 Ring finger domain UPF0257 PF06788.13 ETO05275.1 - 0.014 15.2 0.8 0.18 11.6 0.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0257) zf_UBZ PF18439.1 ETO05275.1 - 0.048 13.3 1.9 0.43 10.2 0.4 2.7 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C3HC4_3 PF13920.6 ETO05275.1 - 0.088 12.7 10.3 0.92 9.4 3.9 3.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO05275.1 - 0.93 9.8 6.4 6.1 7.2 1.5 3.3 2 1 0 2 2 2 0 RING-H2 zinc finger domain DUF1644 PF07800.12 ETO05275.1 - 2.4 8.2 14.6 11 6.0 14.6 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) RINGv PF12906.7 ETO05275.1 - 2.9 8.1 10.5 0.54 10.4 4.1 2.7 2 1 0 2 2 2 0 RING-variant domain zf-BED PF02892.15 ETO05275.1 - 3 7.9 8.0 34 4.6 0.0 4.0 4 0 0 4 4 4 0 BED zinc finger WD40 PF00400.32 ETO05276.1 - 6e-15 55.4 11.0 0.0038 18.0 0.3 6.4 6 1 0 6 6 6 4 WD domain, G-beta repeat eIF2A PF08662.11 ETO05276.1 - 0.017 15.0 0.3 7.6 6.4 0.0 2.6 3 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A LVIVD PF08309.11 ETO05276.1 - 0.16 11.3 1.0 0.44 9.9 0.3 1.9 2 0 0 2 2 2 0 LVIVD repeat DUF2370 PF10176.9 ETO05276.1 - 0.75 9.4 4.1 22 4.6 2.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) Vfa1 PF08432.10 ETO05277.1 - 0.0008 19.8 8.1 0.00096 19.5 8.1 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Senescence PF06911.12 ETO05281.1 - 6e-18 65.8 13.3 6e-18 65.8 13.3 1.8 2 0 0 2 2 2 1 Senescence-associated protein HSP90 PF00183.18 ETO05282.1 - 6.9e-45 153.9 16.9 6.2e-29 101.3 8.0 2.1 1 1 1 2 2 2 2 Hsp90 protein Imm12 PF15560.6 ETO05282.1 - 0.081 12.9 1.1 0.17 11.8 0.8 1.8 1 1 0 1 1 1 0 Immunity protein 12 Ribosomal_S4 PF00163.19 ETO05282.1 - 2.1 9.3 5.0 3.6 8.6 0.8 2.5 2 0 0 2 2 2 0 Ribosomal protein S4/S9 N-terminal domain Reeler PF02014.16 ETO05283.1 - 0.22 12.3 1.0 0.96 10.2 0.2 2.1 2 0 0 2 2 2 0 Reeler domain DUF4827 PF16109.5 ETO05284.1 - 0.024 14.6 0.1 0.028 14.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4827) Bse634I PF07832.11 ETO05284.1 - 0.027 13.8 0.5 0.044 13.1 0.3 1.4 1 1 0 1 1 1 0 Cfr10I/Bse634I restriction endonuclease Fanconi_A PF03511.14 ETO05284.1 - 0.048 13.6 0.2 0.14 12.1 0.0 1.9 2 0 0 2 2 2 0 Fanconi anaemia group A protein CAP_GLY PF01302.25 ETO05285.1 - 9.1e-06 25.6 0.4 1.7e-05 24.8 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain YfhO PF09586.10 ETO05285.1 - 3.9 5.6 6.8 6.3 4.9 6.8 1.3 1 0 0 1 1 1 0 Bacterial membrane protein YfhO B56 PF01603.20 ETO05286.1 - 1.4e-33 116.6 0.6 1.7e-33 116.2 0.6 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) WD40 PF00400.32 ETO05287.1 - 1.2e-64 212.7 17.7 6.2e-10 39.5 0.3 8.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05287.1 - 8.5e-26 90.1 7.1 0.0031 17.8 0.0 8.5 3 1 6 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05287.1 - 1.8e-14 53.4 0.1 0.023 13.7 0.0 6.4 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05287.1 - 1.5e-11 44.2 2.9 0.0092 15.3 0.0 5.5 3 1 2 6 6 6 4 WD40-like domain PD40 PF07676.12 ETO05287.1 - 4e-08 33.0 2.2 11 6.1 0.1 6.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO05287.1 - 1.6e-07 30.3 4.9 0.69 8.5 0.0 5.7 3 1 3 6 6 6 3 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO05287.1 - 1.4e-06 28.4 2.8 0.4 11.0 0.0 5.6 6 0 0 6 6 6 2 Kelch motif Cytochrom_D1 PF02239.16 ETO05287.1 - 4.7e-05 22.1 0.1 0.0039 15.8 0.1 2.4 1 1 2 3 3 3 1 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO05287.1 - 6e-05 22.8 2.2 0.11 12.5 0.1 4.8 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO05287.1 - 0.00095 18.7 0.0 1 9.0 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO05287.1 - 0.017 15.1 1.2 0.37 10.8 0.0 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Proteasome_A_N PF10584.9 ETO05287.1 - 0.11 12.2 6.8 12 5.7 0.0 4.9 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF5122 PF17164.4 ETO05287.1 - 0.18 12.1 1.0 26 5.2 0.0 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller zf-TRAF PF02176.18 ETO05289.1 - 0.00017 22.2 4.0 0.00017 22.2 4.0 2.8 2 0 0 2 2 2 1 TRAF-type zinc finger WD40 PF00400.32 ETO05290.1 - 5.4e-19 68.2 6.0 1.6e-06 28.7 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05290.1 - 0.00022 21.5 0.1 1.4 9.2 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05290.1 - 0.00034 19.4 0.9 0.82 8.2 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Peptidase_C9 PF01707.16 ETO05290.1 - 0.094 12.3 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase family C9 DNA_primase_S PF01896.19 ETO05291.1 - 0.017 15.2 0.2 0.021 14.8 0.2 1.2 1 0 0 1 1 1 0 DNA primase small subunit Yop-YscD_cpl PF16697.5 ETO05292.1 - 2e-08 34.4 0.1 3.7e-08 33.6 0.1 1.4 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 ETO05292.1 - 1.9e-07 31.3 0.5 4e-07 30.3 0.5 1.6 1 0 0 1 1 1 1 FHA domain MRI PF15325.6 ETO05292.1 - 0.0038 18.3 1.4 0.0074 17.4 1.4 1.4 1 0 0 1 1 1 1 Modulator of retrovirus infection 2OG-FeII_Oxy_3 PF13640.6 ETO05294.1 - 0.00039 21.3 0.0 0.00056 20.7 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIL PF01843.19 ETO05297.1 - 0.049 13.9 0.4 2.3 8.5 0.1 2.6 2 1 0 2 2 2 0 DIL domain Bcl-2 PF00452.19 ETO05297.1 - 0.1 13.3 0.0 0.21 12.3 0.0 1.5 1 0 0 1 1 1 0 Apoptosis regulator proteins, Bcl-2 family Cytochrom_C PF00034.21 ETO05297.1 - 0.13 13.4 0.0 8 7.7 0.0 3.0 3 1 0 3 3 3 0 Cytochrome c MinC_N PF05209.13 ETO05297.1 - 0.33 10.9 2.1 5.9 6.9 0.0 2.8 2 1 2 4 4 4 0 Septum formation inhibitor MinC, N-terminal domain RabGAP-TBC PF00566.18 ETO05300.1 - 1.4e-10 41.2 2.2 2.3e-10 40.5 2.2 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Peptidase_M54 PF07998.11 ETO05301.1 - 0.00015 21.8 0.5 0.00031 20.8 0.5 1.5 1 0 0 1 1 1 1 Peptidase family M54 Metallopep PF12044.8 ETO05301.1 - 0.00088 18.0 0.2 0.00088 18.0 0.2 1.9 2 0 0 2 2 2 1 Putative peptidase family Peptidase_M10 PF00413.24 ETO05301.1 - 0.0013 18.7 0.0 0.0032 17.3 0.0 1.4 1 1 0 1 1 1 1 Matrixin Reprolysin_4 PF13583.6 ETO05301.1 - 0.011 15.5 0.1 0.021 14.5 0.1 1.5 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like FAM176 PF14851.6 ETO05301.1 - 0.038 13.6 8.2 6 6.5 0.3 3.3 3 0 0 3 3 3 0 FAM176 family Peptidase_M57 PF12388.8 ETO05301.1 - 0.089 12.4 0.9 0.2 11.2 0.9 1.5 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase Zincin_1 PF06262.11 ETO05301.1 - 0.11 12.7 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Zincin-like metallopeptidase GEN1_C PF18380.1 ETO05301.1 - 0.12 13.2 0.2 0.12 13.2 0.2 3.7 4 1 0 4 4 4 0 Holliday junction resolvase Gen1 C-terminal domain Reprolysin_5 PF13688.6 ETO05301.1 - 0.14 12.2 2.9 0.12 12.5 0.7 2.1 2 0 0 2 2 2 0 Metallo-peptidase family M12 RXT2_N PF08595.11 ETO05301.1 - 0.55 10.2 13.4 12 5.9 0.5 3.4 3 0 0 3 3 3 0 RXT2-like, N-terminal Folate_carrier PF01770.18 ETO05301.1 - 2.2 6.9 4.0 0.71 8.5 0.4 1.9 2 0 0 2 2 2 0 Reduced folate carrier Reprolysin_3 PF13582.6 ETO05301.1 - 8.7 6.9 7.9 0.27 11.7 0.3 2.5 3 1 0 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like WD40 PF00400.32 ETO05302.1 - 3.4e-125 404.3 57.3 3.7e-09 37.1 0.2 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05302.1 - 2e-28 98.5 16.6 0.22 11.9 0.0 13.4 1 1 14 15 15 15 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05302.1 - 4e-21 75.3 4.0 0.2 10.6 0.0 12.9 1 1 14 15 15 15 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05302.1 - 6.3e-18 65.1 15.8 4.9e-06 26.1 0.2 8.8 1 1 10 11 11 11 5 WD40-like domain Nup160 PF11715.8 ETO05302.1 - 2.3e-15 56.3 28.6 0.56 8.8 0.2 13.4 4 3 9 14 14 14 7 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO05302.1 - 1.7e-08 34.6 15.7 0.44 10.6 0.0 9.8 4 2 7 11 11 11 2 Family of unknown function (DUF5570) DUF5046 PF16465.5 ETO05302.1 - 1.2e-06 28.2 0.1 3.9 6.9 0.0 5.6 3 1 2 7 7 7 2 Domain of unknown function (DUF5046) PD40 PF07676.12 ETO05302.1 - 0.00023 21.0 22.3 1.7 8.7 0.1 9.2 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO05302.1 - 0.0016 17.0 6.4 2.3 6.6 0.1 5.2 5 1 0 6 6 6 2 Cytochrome D1 heme domain POLO_box PF00659.18 ETO05302.1 - 0.002 18.3 14.5 0.55 10.5 0.1 8.5 10 1 1 11 11 11 1 POLO box duplicated region Mid2 PF04478.12 ETO05302.1 - 0.0021 17.9 1.1 20 5.0 0.0 5.1 4 1 1 5 5 5 0 Mid2 like cell wall stress sensor Frtz PF11768.8 ETO05302.1 - 0.0025 16.2 0.7 0.33 9.2 0.0 3.3 3 1 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 ETO05302.1 - 0.086 11.9 0.2 5.2 6.0 0.0 3.3 3 1 0 3 3 3 0 VID27 C-terminal WD40-like domain LytR_cpsA_psr PF03816.14 ETO05302.1 - 0.11 12.7 0.1 23 5.1 0.0 2.9 1 1 1 2 2 2 0 Cell envelope-related transcriptional attenuator domain Spc29 PF17082.5 ETO05302.1 - 2.5 7.9 5.5 13 5.6 0.0 4.5 6 0 0 6 6 6 0 Spindle Pole Component 29 WD40 PF00400.32 ETO05303.1 - 6.8e-14 52.0 11.0 1.6e-06 28.7 2.2 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05303.1 - 0.0056 16.9 0.1 0.033 14.5 0.1 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Mit_KHE1 PF10173.9 ETO05304.1 - 0.027 14.5 0.0 0.034 14.2 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related TPR_12 PF13424.6 ETO05306.1 - 3e-76 251.7 4.2 7.8e-24 83.8 0.1 4.7 3 1 2 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO05306.1 - 4.3e-55 182.2 0.0 1.5e-10 40.6 0.0 6.7 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05306.1 - 3.2e-45 150.2 30.4 4.3e-09 35.8 0.3 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05306.1 - 8.1e-41 135.1 3.7 1.6e-07 30.8 0.0 6.6 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05306.1 - 7.9e-35 116.2 21.9 1.6e-06 27.8 0.7 6.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05306.1 - 1.2e-33 112.4 35.0 8e-08 31.9 0.7 6.7 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO05306.1 - 3.3e-21 74.1 2.2 0.012 15.9 0.0 6.9 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO05306.1 - 1.3e-16 61.0 0.0 0.014 16.1 0.0 6.0 2 1 4 6 6 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO05306.1 - 4.8e-14 52.0 0.5 0.052 14.2 0.0 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO05306.1 - 1.1e-11 44.5 0.0 0.084 13.7 0.0 5.2 5 1 1 6 6 4 2 Tetratricopeptide repeat PPR PF01535.20 ETO05306.1 - 2.1e-11 43.2 15.5 0.036 14.3 0.2 6.9 7 0 0 7 7 7 4 PPR repeat TPR_MalT PF17874.1 ETO05306.1 - 2.1e-09 37.3 0.0 6.6e-05 22.4 0.0 2.3 1 1 2 3 3 3 3 MalT-like TPR region DUF5113 PF17140.4 ETO05306.1 - 6.9e-09 35.7 6.2 0.076 12.8 0.0 5.5 6 0 0 6 6 6 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO05306.1 - 4.6e-08 32.6 31.6 0.098 12.4 1.4 9.4 8 3 2 10 10 10 4 TPR repeat ANAPC3 PF12895.7 ETO05306.1 - 1.1e-07 32.0 9.1 0.031 14.5 0.2 5.0 2 1 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO05306.1 - 2.8e-07 30.9 0.1 0.6 10.7 0.0 4.4 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF4810 PF16068.5 ETO05306.1 - 2.3e-06 28.0 2.8 2.5 8.7 0.0 5.3 4 2 0 5 5 5 1 Domain of unknown function (DUF4810) MIT PF04212.18 ETO05306.1 - 6.2e-06 26.2 16.9 0.024 14.7 0.3 6.0 7 0 0 7 7 7 2 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETO05306.1 - 7.3e-06 25.6 1.7 0.00036 20.0 0.2 2.8 1 1 2 3 3 3 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 ETO05306.1 - 3.6e-05 23.5 6.2 0.25 11.1 0.6 3.7 1 1 2 3 3 3 3 26S proteasome subunit RPN7 KH_4 PF13083.6 ETO05306.1 - 0.00019 21.2 0.0 0.015 15.1 0.0 3.0 1 1 2 3 3 3 1 KH domain TPR_3 PF07720.12 ETO05306.1 - 0.0002 21.3 14.6 2.3 8.3 0.4 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Tat PF00539.18 ETO05306.1 - 0.001 19.2 0.3 40 4.5 0.0 5.3 6 0 0 6 6 6 0 Transactivating regulatory protein (Tat) SHNi-TPR PF10516.9 ETO05306.1 - 0.0036 16.7 2.6 7.8 6.0 0.0 5.4 6 0 0 6 6 5 0 SHNi-TPR Fis1_TPR_C PF14853.6 ETO05306.1 - 0.0038 17.3 11.5 2.3 8.3 0.3 5.0 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat TPR_21 PF09976.9 ETO05306.1 - 0.004 16.9 0.9 0.055 13.2 0.0 3.0 2 2 1 3 3 3 1 Tetratricopeptide repeat-like domain Sel1 PF08238.12 ETO05306.1 - 0.015 16.0 10.7 7.2 7.5 0.1 5.9 6 1 0 6 6 5 0 Sel1 repeat PPR_1 PF12854.7 ETO05306.1 - 0.017 14.8 3.7 2.1 8.1 0.2 4.4 5 0 0 5 5 3 0 PPR repeat Vta1_C PF18097.1 ETO05306.1 - 0.021 14.5 0.5 12 5.7 0.0 4.2 6 0 0 6 6 4 0 Vta1 C-terminal domain Pep3_Vps18 PF05131.14 ETO05306.1 - 0.023 14.5 2.1 32 4.3 0.0 4.6 5 0 0 5 5 5 0 Pep3/Vps18/deep orange family SPO22 PF08631.10 ETO05306.1 - 0.045 13.2 3.4 0.25 10.8 0.2 3.0 3 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_9 PF13371.6 ETO05306.1 - 0.055 13.6 0.0 3.5 7.9 0.0 3.0 1 1 1 3 3 3 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO05306.1 - 0.069 12.7 8.7 13 5.5 0.1 5.7 5 1 0 5 5 5 0 Helix-turn-helix bacterial domain SLT PF01464.20 ETO05306.1 - 0.081 12.6 1.7 20 4.9 0.1 3.7 2 1 2 4 4 4 0 Transglycosylase SLT domain Mob_Pre PF01076.19 ETO05306.1 - 0.089 12.6 2.9 6.7 6.5 0.0 3.0 2 1 2 4 4 4 0 Plasmid recombination enzyme DUF627 PF04781.12 ETO05306.1 - 0.42 10.6 7.1 2.5 8.2 1.5 4.4 3 2 1 4 4 4 0 Protein of unknown function (DUF627) Vps39_1 PF10366.9 ETO05306.1 - 0.64 10.3 5.5 24 5.3 0.3 4.4 1 1 4 5 5 5 0 Vacuolar sorting protein 39 domain 1 PPR_2 PF13041.6 ETO05306.1 - 2.1 8.6 13.9 0.99 9.7 0.1 5.6 7 0 0 7 7 7 0 PPR repeat family DUF2207 PF09972.9 ETO05307.1 - 0.02 13.6 0.3 0.025 13.4 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ndc1_Nup PF09531.10 ETO05307.1 - 0.07 11.8 3.2 0.097 11.3 3.0 1.4 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF5344 PF17279.2 ETO05307.1 - 0.086 13.4 1.8 0.17 12.5 1.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5344) DUF2570 PF10828.8 ETO05307.1 - 0.31 10.9 2.6 2.4 8.0 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) ETRAMP PF09716.10 ETO05307.1 - 0.8 9.8 9.4 0.52 10.4 0.3 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) GET2 PF08690.10 ETO05307.1 - 2.6 7.6 8.4 3.5 7.2 8.4 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4446 PF14584.6 ETO05307.1 - 2.9 7.8 7.9 0.98 9.4 3.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4834 PF16118.5 ETO05307.1 - 3.1 8.8 16.5 3 8.9 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 ETO05307.1 - 3.2 6.7 7.8 3.1 6.8 7.2 1.3 1 1 0 1 1 1 0 CLN3 protein Pex2_Pex12 PF04757.14 ETO05307.1 - 5.8 6.4 11.1 17 4.9 11.0 1.8 1 1 0 1 1 1 0 Pex2 / Pex12 amino terminal region WD40 PF00400.32 ETO05308.1 - 1.9e-21 76.0 14.3 4.1e-05 24.2 0.4 5.6 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05308.1 - 2.1e-05 24.7 0.1 1.1 9.6 0.0 3.4 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05308.1 - 0.00047 18.9 1.6 2 7.0 0.0 3.3 2 1 1 3 3 3 3 Nucleoporin Nup120/160 SRP54 PF00448.22 ETO05310.1 - 0.011 15.4 0.3 0.021 14.5 0.3 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Folliculin PF11704.8 ETO05310.1 - 0.046 13.6 5.1 0.19 11.6 1.9 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport WD40 PF00400.32 ETO05311.1 - 2.7e-11 43.8 3.6 1.1e-06 29.2 0.5 3.2 4 1 0 4 4 4 2 WD domain, G-beta repeat WD40 PF00400.32 ETO05312.1 - 2.5e-34 116.7 13.1 7.7e-08 32.9 0.0 5.8 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05312.1 - 6e-09 36.1 0.3 0.0086 16.4 0.0 4.4 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05312.1 - 6.7e-08 31.6 0.9 0.0072 15.0 0.0 3.8 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05312.1 - 7.1e-05 22.3 3.4 0.31 10.3 0.0 3.6 1 1 2 4 4 4 3 WD40-like domain fn3_PAP PF17808.1 ETO05312.1 - 0.032 14.4 0.3 6.7 6.9 0.1 2.8 1 1 1 2 2 2 0 Fn3-like domain from Purple Acid Phosphatase GPR15L PF15854.5 ETO05313.1 - 2.6 8.4 7.1 0.83 9.9 0.4 3.0 2 2 1 3 3 3 0 G-protein coupled receptor ligand 15 WD40 PF00400.32 ETO05314.1 - 4e-33 112.9 7.2 4.4e-06 27.3 0.0 6.2 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05314.1 - 3.1e-12 46.6 0.9 0.077 13.3 0.0 5.1 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05314.1 - 8.2e-06 25.0 0.0 0.32 9.9 0.0 4.0 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05314.1 - 4.6e-05 22.9 0.3 0.058 12.7 0.1 2.4 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO05314.1 - 5.9e-05 21.9 4.7 1.3 7.6 0.1 4.5 1 1 3 5 5 5 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO05314.1 - 0.0034 17.4 0.2 0.8 9.8 0.0 3.6 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region DUF5570 PF17731.1 ETO05314.1 - 0.019 15.1 1.3 2.8 8.1 0.0 3.4 1 1 2 3 3 3 0 Family of unknown function (DUF5570) Peptidase_C69 PF03577.15 ETO05314.1 - 0.025 13.5 0.0 1 8.2 0.0 2.1 2 0 0 2 2 2 0 Peptidase family C69 Transp_Tc5_C PF04236.15 ETO05314.1 - 0.14 12.6 1.2 0.4 11.1 0.0 2.2 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain PD40 PF07676.12 ETO05314.1 - 0.19 11.7 1.2 35 4.5 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO05315.1 - 3e-29 100.6 7.9 1.1e-07 32.4 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO05315.1 - 5.8e-06 25.2 5.5 0.12 11.0 0.1 3.6 1 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05315.1 - 6.9e-06 25.6 0.1 0.053 12.8 0.0 2.9 1 1 2 3 3 3 2 WD40-like domain ANAPC4_WD40 PF12894.7 ETO05315.1 - 1.4e-05 25.3 0.4 0.18 12.1 0.1 2.5 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05315.1 - 0.00045 19.3 0.0 0.055 12.4 0.0 2.2 2 0 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF727 PF05303.12 ETO05315.1 - 0.057 13.5 0.0 4.5 7.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF727) RasGEF PF00617.19 ETO05316.1 - 3.4e-28 99.0 3.8 7.3e-28 98.0 3.8 1.5 1 0 0 1 1 1 1 RasGEF domain PUB PF09409.10 ETO05317.1 - 1.5e-05 24.8 0.0 3.1e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 PUB domain UNC45-central PF11701.8 ETO05318.1 - 0.01 15.8 1.3 0.07 13.1 0.6 2.3 1 1 1 2 2 2 0 Myosin-binding striated muscle assembly central PUL PF08324.11 ETO05318.1 - 0.023 13.9 3.9 0.14 11.4 3.9 1.9 1 1 0 1 1 1 0 PUL domain Zfx_Zfy_act PF04704.13 ETO05318.1 - 0.038 13.1 0.1 0.059 12.5 0.1 1.2 1 0 0 1 1 1 0 Zfx / Zfy transcription activation region Atx10homo_assoc PF09759.9 ETO05319.1 - 1.3e-07 31.5 3.7 6.7e-06 26.0 0.8 2.5 2 0 0 2 2 2 2 Spinocerebellar ataxia type 10 protein domain DUF5578 PF17741.1 ETO05319.1 - 0.00023 20.7 0.5 0.00039 19.9 0.2 1.6 1 1 1 2 2 2 1 Family of unknown function (DUF5578) WAPL PF07814.13 ETO05319.1 - 0.00026 19.9 1.6 0.0005 19.0 0.9 1.7 1 1 1 2 2 2 1 Wings apart-like protein regulation of heterochromatin DUF3361 PF11841.8 ETO05319.1 - 0.015 15.3 1.4 0.1 12.5 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) Arm_2 PF04826.13 ETO05319.1 - 0.016 14.7 3.5 0.073 12.5 0.1 2.2 1 1 1 2 2 2 0 Armadillo-like KAP PF05804.12 ETO05319.1 - 0.018 13.2 2.5 0.4 8.8 0.2 2.1 1 1 1 2 2 2 0 Kinesin-associated protein (KAP) Arm PF00514.23 ETO05319.1 - 0.027 14.5 8.2 0.19 11.8 0.0 4.6 4 2 0 5 5 5 0 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 ETO05319.1 - 0.033 13.5 0.1 0.074 12.3 0.1 1.5 1 1 0 1 1 1 0 V-ATPase subunit H HEAT PF02985.22 ETO05319.1 - 0.18 12.2 1.0 4.2 7.9 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat DUF383 PF04063.14 ETO05319.1 - 0.42 10.2 3.8 12 5.5 3.8 2.7 1 1 0 1 1 1 0 Domain of unknown function (DUF383) Arm PF00514.23 ETO05320.1 - 5.2e-05 23.1 5.7 65 3.8 0.0 7.9 7 2 2 9 9 9 0 Armadillo/beta-catenin-like repeat RTTN_N PF14726.6 ETO05320.1 - 0.0012 19.6 0.7 6.7 7.6 0.0 4.2 3 1 0 3 3 3 2 Rotatin, an armadillo repeat protein, centriole functioning DUF3361 PF11841.8 ETO05320.1 - 0.0024 17.8 0.1 4.6 7.2 0.0 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF3361) TetR_C_5 PF08360.11 ETO05320.1 - 0.0024 18.0 0.2 0.036 14.3 0.0 2.4 2 0 0 2 2 2 1 QacR-like protein, C-terminal region DUF3135 PF11333.8 ETO05320.1 - 0.0042 17.3 0.1 2.2 8.6 0.0 3.0 2 0 0 2 2 2 1 Protein of unknown function (DUF3135) Rrf2 PF02082.20 ETO05320.1 - 0.08 13.3 0.0 2.4 8.5 0.0 2.9 2 0 0 2 2 2 0 Transcriptional regulator Cdd1 PF11731.8 ETO05320.1 - 0.1 12.8 0.1 2.2 8.6 0.0 3.0 2 0 0 2 2 2 0 Pathogenicity locus V-ATPase_H_C PF11698.8 ETO05320.1 - 0.27 11.4 2.0 4.1 7.5 0.1 3.3 2 2 2 4 4 4 0 V-ATPase subunit H CSTF2_hinge PF14327.6 ETO05320.1 - 0.54 10.8 3.3 17 6.0 0.2 4.0 3 1 1 4 4 4 0 Hinge domain of cleavage stimulation factor subunit 2 Lambda_Kil PF06301.11 ETO05321.1 - 0.11 12.2 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage lambda Kil protein SprA-related PF12118.8 ETO05322.1 - 0.18 10.9 16.8 0.21 10.7 16.8 1.0 1 0 0 1 1 1 0 SprA-related family CDC45 PF02724.14 ETO05323.1 - 0.00088 17.7 5.5 0.0011 17.3 5.5 1.2 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO05323.1 - 0.053 11.8 19.5 0.068 11.4 18.7 1.5 2 0 0 2 2 2 0 Nop14-like family BUD22 PF09073.10 ETO05323.1 - 0.083 12.2 19.9 0.13 11.6 19.9 1.2 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 ETO05323.1 - 0.12 11.6 1.8 0.14 11.3 1.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2151 PF10221.9 ETO05323.1 - 0.13 10.9 8.4 0.04 12.5 4.4 1.8 2 0 0 2 2 2 0 Cell cycle and development regulator DUF913 PF06025.12 ETO05323.1 - 0.13 11.2 3.9 0.2 10.6 3.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO05323.1 - 0.17 10.6 6.2 0.27 10.0 6.2 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO05323.1 - 0.68 8.6 5.5 1 8.0 5.5 1.2 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO05323.1 - 1.6 7.4 8.2 2.3 6.9 8.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RPN2_C PF18004.1 ETO05323.1 - 4.8 7.1 12.9 9.2 6.2 12.9 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4834 PF16118.5 ETO05323.1 - 8.5 7.4 8.1 0.11 13.5 0.6 1.8 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) DNA_pol_phi PF04931.13 ETO05323.1 - 9.9 4.1 23.1 17 3.3 23.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi Kelch_2 PF07646.15 ETO05324.1 - 0.0038 17.1 0.4 0.018 15.0 0.4 2.2 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO05324.1 - 0.013 15.5 0.8 0.9 9.6 0.1 3.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO05324.1 - 0.022 14.4 0.1 0.11 12.1 0.2 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO05324.1 - 0.037 14.3 0.4 0.57 10.6 0.0 3.1 3 0 0 3 3 3 0 Kelch motif DUF987 PF06174.11 ETO05324.1 - 0.099 12.6 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF987) NACHT PF05729.12 ETO05325.1 - 2.7e-13 50.2 0.0 5.2e-13 49.3 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO05325.1 - 2.9e-06 27.8 0.2 1.6e-05 25.3 0.1 2.2 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ETO05325.1 - 0.0014 17.8 0.0 0.0028 16.9 0.0 1.5 1 0 0 1 1 1 1 NB-ARC domain Imm19 PF15563.6 ETO05325.1 - 0.028 13.9 0.0 0.052 13.0 0.0 1.5 1 0 0 1 1 1 0 Immunity protein 19 AAA_22 PF13401.6 ETO05325.1 - 0.037 14.3 0.0 0.13 12.6 0.0 2.0 2 0 0 2 2 2 0 AAA domain Torsin PF06309.11 ETO05325.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Torsin HEAT PF02985.22 ETO05326.1 - 8.4e-10 38.1 0.5 0.34 11.3 0.0 7.8 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.6 ETO05326.1 - 1.4e-07 31.8 0.0 0.0005 20.4 0.0 4.2 3 1 3 6 6 4 2 HEAT repeats HEAT_EZ PF13513.6 ETO05326.1 - 1.4e-06 28.6 0.0 0.11 13.0 0.0 6.0 7 1 0 7 7 6 1 HEAT-like repeat Ank_2 PF12796.7 ETO05326.1 - 1.9e-06 28.4 0.6 3.4e-05 24.3 0.0 3.5 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO05326.1 - 4.9e-06 26.7 0.1 0.00012 22.3 0.0 2.9 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO05326.1 - 9.5e-06 26.1 0.2 4e-05 24.1 0.1 2.2 2 0 0 2 2 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO05326.1 - 1.1e-05 25.4 0.0 0.0093 16.4 0.0 3.6 2 0 0 2 2 2 1 Ankyrin repeat RTP1_C1 PF10363.9 ETO05326.1 - 0.0079 16.4 6.0 6.1 7.1 0.7 4.8 4 1 0 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO05326.1 - 0.11 13.2 0.0 6.2 7.8 0.0 3.3 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat TIP120 PF08623.10 ETO05326.1 - 0.12 12.1 21.6 0.76 9.5 0.3 6.7 3 1 5 8 8 8 0 TATA-binding protein interacting (TIP20) Ank PF00023.30 ETO05326.1 - 0.19 12.3 0.2 1.1 9.8 0.0 2.5 2 0 0 2 2 1 0 Ankyrin repeat Vac14_Fab1_bd PF12755.7 ETO05326.1 - 2.2 8.9 13.1 5.4 7.7 0.7 5.3 3 1 2 6 6 6 0 Vacuolar 14 Fab1-binding region Ldh_1_N PF00056.23 ETO05328.1 - 0.00044 20.4 0.0 0.00081 19.5 0.0 1.5 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain DUF1980 PF09323.10 ETO05328.1 - 0.0084 16.0 0.2 0.024 14.6 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF1980) Coat_X PF07552.11 ETO05328.1 - 0.09 12.6 2.3 0.26 11.2 2.3 1.7 1 0 0 1 1 1 0 Spore Coat Protein X and V domain CLZ PF16526.5 ETO05330.1 - 7.4 7.0 16.1 0.21 12.0 4.5 2.9 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NINJA_B PF16136.5 ETO05331.1 - 2.7 8.4 4.9 0.71 10.3 1.1 1.9 1 1 1 2 2 2 0 Putative nuclear localisation signal eIF3_N PF09440.10 ETO05332.1 - 0.026 14.9 4.2 0.045 14.2 4.2 1.5 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain NLBH PF05211.12 ETO05332.1 - 1 8.9 11.0 2.6 7.6 7.8 2.4 1 1 2 3 3 3 0 Neuraminyllactose-binding hemagglutinin precursor (NLBH) DUF4672 PF15716.5 ETO05335.1 - 0.033 13.8 0.5 0.033 13.8 0.5 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4672) EMC3_TMCO1 PF01956.16 ETO05335.1 - 0.64 9.7 5.8 0.063 13.0 0.3 2.2 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF1754 PF08555.10 ETO05335.1 - 1 10.2 18.9 0.095 13.5 4.5 2.6 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) V_ATPase_I PF01496.19 ETO05335.1 - 8 4.2 13.4 21 2.8 13.7 1.6 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family BT1 PF03092.16 ETO05336.1 - 0.18 10.0 0.5 0.21 9.8 0.5 1.0 1 0 0 1 1 1 0 BT1 family DUF3408 PF11888.8 ETO05336.1 - 7.8 6.6 15.2 0.1 12.7 4.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3408) TPR_12 PF13424.6 ETO05338.1 - 3.7e-18 65.6 0.8 9.5e-12 45.0 0.1 3.0 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO05338.1 - 1.1e-12 47.4 0.1 0.00032 20.4 0.0 3.5 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05338.1 - 3.4e-12 45.5 0.2 0.011 15.8 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05338.1 - 4.5e-12 45.2 7.2 1.2e-05 24.9 0.6 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05338.1 - 8e-10 38.1 7.2 7.6e-06 25.6 0.5 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05338.1 - 1.4e-07 31.1 9.0 0.0077 16.4 0.6 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO05338.1 - 3.5e-06 26.6 4.9 0.017 14.8 0.2 3.6 3 0 0 3 3 3 2 TPR repeat SHNi-TPR PF10516.9 ETO05338.1 - 0.0013 18.2 3.2 1.6 8.2 0.0 4.0 4 1 0 4 4 4 2 SHNi-TPR ANAPC3 PF12895.7 ETO05338.1 - 0.0084 16.3 2.3 0.014 15.6 1.1 2.1 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ETO05338.1 - 0.16 12.0 2.3 2.1 8.5 0.1 3.1 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat MIT PF04212.18 ETO05338.1 - 0.67 10.1 13.4 7.4 6.7 0.1 4.6 2 1 3 5 5 5 0 MIT (microtubule interacting and transport) domain NUMOD1 PF07453.13 ETO05338.1 - 0.88 9.9 5.7 7.1 7.0 2.4 3.3 2 1 0 2 2 2 0 NUMOD1 domain TPR_17 PF13431.6 ETO05338.1 - 2.7 8.6 9.6 0.55 10.7 3.4 3.1 4 1 0 4 4 2 0 Tetratricopeptide repeat RAC_head PF16717.5 ETO05339.1 - 0.017 16.1 0.7 0.25 12.3 0.1 2.6 3 0 0 3 3 3 0 Ribosome-associated complex head domain XH PF03469.14 ETO05339.1 - 0.064 13.2 0.3 0.82 9.6 0.0 2.4 2 0 0 2 2 2 0 XH domain SecA_DEAD PF07517.14 ETO05340.1 - 3.6e-10 39.6 0.0 2.4e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 SecA DEAD-like domain Bap31_Bap29_C PF18035.1 ETO05340.1 - 0.077 13.0 0.6 0.24 11.4 0.6 1.9 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain AAA PF00004.29 ETO05340.1 - 0.097 13.1 0.2 0.63 10.5 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) HSP90 PF00183.18 ETO05341.1 - 9.1e-05 21.6 1.6 0.00034 19.6 0.7 2.2 1 1 1 2 2 2 1 Hsp90 protein HSP90 PF00183.18 ETO05342.1 - 6.6e-40 137.5 5.2 8.7e-21 74.4 0.5 2.0 1 1 1 2 2 2 2 Hsp90 protein PPP4R2 PF09184.11 ETO05343.1 - 0.0081 15.8 0.1 0.02 14.5 0.1 1.6 1 0 0 1 1 1 1 PPP4R2 DUF4266 PF14086.6 ETO05343.1 - 0.35 11.8 2.6 1.2 10.2 2.6 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4266) DUF913 PF06025.12 ETO05343.1 - 2.8 6.8 7.6 0.31 10.0 1.3 2.1 1 1 0 2 2 2 0 Domain of Unknown Function (DUF913) Exo_endo_phos PF03372.23 ETO05344.1 - 0.13 11.8 0.0 0.15 11.5 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family SPRY PF00622.28 ETO05345.1 - 2.1e-27 95.6 0.1 8.6e-27 93.6 0.1 2.2 1 0 0 1 1 1 1 SPRY domain zf-RanBP PF00641.18 ETO05345.1 - 3.9e-06 26.1 10.9 0.003 16.8 1.7 2.5 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO05345.1 - 0.037 13.4 8.9 0.96 8.9 1.1 3.5 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ETO05345.1 - 2 8.5 10.2 0.23 11.6 0.1 3.2 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger DZR PF12773.7 ETO05345.1 - 2.8 8.0 11.2 9.9 6.3 11.2 2.0 1 1 0 1 1 1 0 Double zinc ribbon HECT PF00632.25 ETO05346.1 - 3.5e-67 227.1 0.0 3.9e-65 220.4 0.0 2.9 2 1 0 3 3 3 1 HECT-domain (ubiquitin-transferase) zf-RanBP PF00641.18 ETO05346.1 - 5.5e-05 22.4 1.3 0.00018 20.8 1.3 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO05346.1 - 0.03 13.7 0.2 0.11 11.9 0.2 2.1 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ETO05346.1 - 0.18 11.9 0.0 0.62 10.2 0.0 2.0 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger ATP19 PF11022.8 ETO05347.1 - 0.082 13.3 0.1 2.7 8.4 0.0 2.4 2 0 0 2 2 2 0 ATP synthase subunit K TMEM210 PF15195.6 ETO05347.1 - 0.15 12.5 0.0 0.33 11.4 0.0 1.5 1 0 0 1 1 1 0 TMEM210 family U1snRNP70_N PF12220.8 ETO05348.1 - 0.0025 18.4 3.3 0.0043 17.7 3.3 1.5 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF496 PF04363.12 ETO05350.1 - 0.069 13.2 6.9 0.039 14.0 4.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF496) Laminin_I PF06008.14 ETO05351.1 - 0.0025 17.6 5.6 0.0025 17.6 5.6 1.6 2 0 0 2 2 2 1 Laminin Domain I CENP-F_leu_zip PF10473.9 ETO05351.1 - 0.011 15.8 3.9 0.011 15.7 2.0 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OMS28_porin PF03532.13 ETO05351.1 - 0.055 12.7 3.1 0.081 12.1 2.3 1.5 1 1 1 2 2 2 0 OMS28 porin Sec34 PF04136.15 ETO05351.1 - 0.063 13.2 6.0 3.6 7.5 3.9 2.8 2 1 1 3 3 3 0 Sec34-like family DUF4726 PF15855.5 ETO05351.1 - 0.09 13.0 0.9 5.3 7.3 0.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4726) DUF1664 PF07889.12 ETO05351.1 - 0.17 11.9 12.3 0.71 9.9 7.9 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 ETO05351.1 - 0.18 11.9 8.8 1.1 9.3 5.4 2.7 2 1 1 3 3 3 0 Laminin Domain II ERM PF00769.19 ETO05351.1 - 0.27 11.0 11.8 0.048 13.5 8.2 1.7 2 1 0 2 2 2 0 Ezrin/radixin/moesin family Snapin_Pallidin PF14712.6 ETO05351.1 - 0.73 10.3 10.0 0.073 13.5 1.6 2.9 2 1 1 3 3 3 0 Snapin/Pallidin Atg14 PF10186.9 ETO05351.1 - 0.82 8.7 7.4 1.1 8.3 7.3 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TolA_bind_tri PF16331.5 ETO05351.1 - 1.1 9.4 18.0 2.8 8.1 14.4 2.4 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF2203 PF09969.9 ETO05351.1 - 1.4 9.6 7.9 2.3 9.0 4.3 2.6 2 2 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1492 PF07374.11 ETO05351.1 - 3 8.1 7.6 1 9.6 1.4 2.9 2 2 0 3 3 3 0 Protein of unknown function (DUF1492) DUF948 PF06103.11 ETO05351.1 - 4 7.8 7.7 72 3.7 5.5 2.9 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.32 ETO05352.1 - 2.6e-05 24.9 0.4 0.1 13.5 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat LRR_10 PF18805.1 ETO05352.1 - 0.055 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat WD40 PF00400.32 ETO05353.1 - 3.4e-65 214.4 19.9 5.1e-11 43.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05353.1 - 1.9e-21 76.1 6.9 0.0011 19.2 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05353.1 - 1.2e-14 54.0 1.4 0.039 12.9 0.0 6.3 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05353.1 - 3e-12 46.5 4.3 0.00061 19.2 0.5 4.4 2 2 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO05353.1 - 2.9e-09 36.1 4.9 0.093 11.4 0.3 5.3 2 2 2 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO05353.1 - 1.4e-06 27.1 1.0 0.0082 14.7 0.1 3.3 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO05353.1 - 0.00019 20.3 7.1 0.3 9.8 0.1 4.4 1 1 1 3 3 3 2 Nup133 N terminal like PQQ PF01011.21 ETO05353.1 - 0.00071 19.4 0.0 51 4.0 0.0 5.1 5 0 0 5 5 5 0 PQQ enzyme repeat PQQ_2 PF13360.6 ETO05353.1 - 0.00075 19.2 0.1 0.045 13.3 0.0 2.6 1 1 1 2 2 2 1 PQQ-like domain PD40 PF07676.12 ETO05353.1 - 0.0011 18.8 2.9 49 4.0 0.0 5.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 ETO05353.1 - 0.0028 17.2 0.0 3.3 7.1 0.0 2.7 1 1 2 3 3 3 2 Domain of unknown function (DUF5046) SH3_4 PF06347.13 ETO05353.1 - 0.023 14.5 0.0 13 5.6 0.0 3.1 3 0 0 3 3 3 0 Bacterial SH3 domain HPS6 PF15702.5 ETO05353.1 - 0.064 11.3 0.0 1.3 6.9 0.0 2.3 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 6 protein DUF2963 PF11178.8 ETO05353.1 - 0.072 12.8 1.2 49 3.7 0.0 4.4 2 2 1 3 3 3 0 Protein of unknown function (DUF2963) Big_7 PF17957.1 ETO05353.1 - 0.13 13.1 0.0 1.5 9.7 0.0 2.7 3 0 0 3 3 3 0 Bacterial Ig domain Ricin_B_lectin PF00652.22 ETO05353.1 - 0.66 10.2 5.0 1.7 8.9 2.3 2.7 2 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain WD40 PF00400.32 ETO05354.1 - 7e-16 58.3 9.1 2.5e-08 34.4 1.9 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO05354.1 - 0.00011 21.1 0.9 0.005 15.6 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05354.1 - 0.017 15.4 0.1 0.059 13.7 0.0 1.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO05355.1 - 7.7e-118 381.0 48.4 7.4e-08 32.9 0.1 16.4 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05355.1 - 1e-27 96.2 21.3 0.0033 17.7 0.0 12.5 1 1 10 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05355.1 - 4.3e-18 65.4 8.3 0.13 11.2 0.0 12.5 1 1 12 14 14 14 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05355.1 - 9.2e-18 64.6 18.7 5.2e-05 22.7 2.0 7.0 3 2 4 7 7 7 4 WD40-like domain eIF2A PF08662.11 ETO05355.1 - 6.9e-09 35.9 6.1 0.016 15.1 0.2 5.9 2 1 1 5 5 5 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO05355.1 - 1.9e-07 30.7 12.3 1.9 7.7 0.0 8.2 4 4 3 8 8 8 3 Neuroblastoma-amplified sequence, N terminal Pentapeptide PF00805.22 ETO05355.1 - 2.2e-07 30.4 0.8 4.5e-07 29.4 0.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) HARP PF07443.13 ETO05355.1 - 1.4e-06 27.8 2.6 12 5.7 0.0 8.6 11 0 0 11 11 11 1 HepA-related protein (HARP) Cytochrom_D1 PF02239.16 ETO05355.1 - 2.4e-05 23.0 11.5 0.39 9.2 0.1 5.3 2 2 3 6 6 6 3 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO05355.1 - 0.00053 18.8 4.7 0.87 8.3 0.2 5.9 2 1 5 7 7 7 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pentapeptide_4 PF13599.6 ETO05355.1 - 0.00088 19.4 0.2 0.0055 16.8 0.0 2.4 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Mid2 PF04478.12 ETO05355.1 - 0.002 18.0 7.7 2.4 8.0 0.1 5.8 5 2 2 7 7 7 1 Mid2 like cell wall stress sensor Pentapeptide_3 PF13576.6 ETO05355.1 - 0.072 13.2 0.1 0.2 11.9 0.1 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO05355.1 - 0.084 12.8 15.9 40 4.3 0.1 9.2 11 0 0 11 11 11 0 WD40-like Beta Propeller Repeat DUF4988 PF16378.5 ETO05355.1 - 1.2 8.8 6.8 3.9 7.1 0.1 4.6 5 1 0 5 5 5 0 Domain of unknown function WD40 PF00400.32 ETO05359.1 - 1.5e-60 199.7 24.6 2.8e-10 40.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05359.1 - 2.3e-20 72.7 1.5 0.0014 18.8 0.0 6.7 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05359.1 - 6.1e-19 68.2 0.9 0.03 13.3 0.0 6.4 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05359.1 - 1.5e-05 24.5 0.7 0.04 13.3 0.1 2.9 2 1 0 3 3 3 2 WD40-like domain Nbas_N PF15492.6 ETO05359.1 - 2.7e-05 23.6 2.1 4 6.7 0.0 4.3 1 1 3 5 5 5 3 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO05359.1 - 0.00013 22.0 1.3 6.7 6.8 0.0 4.8 2 1 3 5 5 5 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO05359.1 - 0.00017 21.4 11.3 2.5 8.1 0.1 6.4 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO05359.1 - 0.00052 20.1 0.2 0.15 12.2 0.0 4.3 2 1 4 6 6 6 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO05359.1 - 0.00075 18.1 0.4 0.65 8.5 0.0 3.0 3 0 0 3 3 3 1 Cytochrome D1 heme domain AcetylCoA_hyd_C PF13336.6 ETO05359.1 - 0.0013 18.7 0.1 11 5.9 0.0 3.7 2 1 1 4 4 4 1 Acetyl-CoA hydrolase/transferase C-terminal domain Coatomer_WDAD PF04053.14 ETO05359.1 - 0.0015 17.6 0.2 0.6 9.1 0.0 2.9 2 1 0 3 3 3 2 Coatomer WD associated region ROS_MUCR PF05443.11 ETO05359.1 - 0.0026 17.8 0.9 13 5.9 0.1 4.6 2 1 1 3 3 3 0 ROS/MUCR transcriptional regulator protein Resistin PF06954.11 ETO05359.1 - 0.0097 16.4 0.1 28 5.3 0.0 4.0 2 1 1 4 4 4 0 Resistin SBD PF17882.1 ETO05359.1 - 0.017 15.0 0.1 75 3.2 0.0 4.0 2 1 2 4 4 4 0 OAA-family lectin sugar binding domain DUF1797 PF08796.10 ETO05359.1 - 0.058 13.5 0.0 5 7.3 0.0 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF1797) Pro_isomerase PF00160.21 ETO05360.1 - 2.2e-44 151.5 0.1 2.7e-44 151.2 0.1 1.1 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD tRNA_anti-codon PF01336.25 ETO05362.1 - 6.1e-09 35.7 0.2 1.2e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain RPA_C PF08784.11 ETO05362.1 - 0.00013 22.6 0.4 0.00054 20.6 0.4 2.1 1 1 0 1 1 1 1 Replication protein A C terminal RMI2 PF16100.5 ETO05362.1 - 0.12 12.2 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 RecQ-mediated genome instability protein 2 WD40 PF00400.32 ETO05363.1 - 1.6e-28 98.3 32.5 9.2e-07 29.5 5.9 6.9 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05363.1 - 6.7e-08 32.7 3.5 0.066 13.5 0.0 5.3 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05363.1 - 7.1e-05 21.6 1.3 0.23 10.1 0.3 3.7 3 1 0 3 3 3 3 Nucleoporin Nup120/160 DUF1541 PF07563.11 ETO05363.1 - 0.1 12.5 0.0 14 5.7 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) REJ PF02010.15 ETO05364.1 - 0.0098 14.7 7.7 0.01 14.6 1.8 2.4 1 1 1 2 2 2 2 REJ domain mRNA_cap_enzyme PF01331.19 ETO05365.1 - 0.00023 21.0 1.0 0.00029 20.7 1.0 1.2 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DNA_ligase_A_M PF01068.21 ETO05365.1 - 0.024 14.3 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain GP24_25 PF17388.2 ETO05366.1 - 0.007 16.3 0.2 0.015 15.3 0.1 1.7 2 0 0 2 2 2 1 Tail assembly gene products 24 & 25 HEPN_LA2681 PF18733.1 ETO05366.1 - 0.037 13.3 0.1 0.046 13.0 0.1 1.3 1 0 0 1 1 1 0 LA2681-like HEPN SID PF11778.8 ETO05366.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Septation initiation NYN_YacP PF05991.11 ETO05367.1 - 0.026 14.5 0.3 0.03 14.3 0.3 1.1 1 0 0 1 1 1 0 YacP-like NYN domain C1-set PF07654.15 ETO05370.1 - 0.6 10.5 4.0 3.1 8.2 0.0 2.3 1 1 1 2 2 2 0 Immunoglobulin C1-set domain Tubulin PF00091.25 ETO05371.1 - 7.1e-30 104.7 0.3 4.4e-22 79.2 0.2 2.3 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO05371.1 - 0.0091 16.2 0.1 0.018 15.2 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain zinc-ribbon_6 PF10005.9 ETO05372.1 - 0.088 13.5 0.4 0.088 13.5 0.4 2.1 2 0 0 2 2 2 0 zinc-ribbon domain Sec66 PF09802.9 ETO05373.1 - 0.0021 17.7 0.6 0.0066 16.1 0.6 1.8 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 TPR_12 PF13424.6 ETO05375.1 - 3.6e-63 209.8 0.6 5.7e-18 65.0 0.0 4.0 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO05375.1 - 4.1e-36 121.9 0.0 3.8e-08 32.9 0.0 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05375.1 - 2.9e-35 118.7 24.5 1.5e-07 30.9 0.1 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05375.1 - 1.1e-32 109.6 0.3 1e-05 25.2 0.0 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05375.1 - 3.4e-30 101.7 24.1 1.1e-08 34.7 0.1 6.5 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05375.1 - 5.8e-26 88.5 10.5 3.9e-05 23.4 0.0 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO05375.1 - 4.2e-13 48.7 18.5 0.013 15.2 0.6 6.8 5 2 2 7 7 7 5 TPR repeat TPR_14 PF13428.6 ETO05375.1 - 1.6e-06 28.4 0.0 33 5.6 0.0 5.7 6 0 0 6 6 6 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO05375.1 - 7.7e-06 25.8 7.3 0.0094 15.7 0.4 3.8 1 1 3 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 ETO05375.1 - 3e-05 24.5 2.1 1.2 9.9 0.0 4.7 5 0 0 5 5 4 1 Sel1 repeat TPR_6 PF13174.6 ETO05375.1 - 3.8e-05 24.0 0.4 9.2 7.2 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO05375.1 - 4.5e-05 22.8 0.6 4.9 6.7 0.0 5.0 5 0 0 5 5 5 1 SHNi-TPR TPR_3 PF07720.12 ETO05375.1 - 8.7e-05 22.4 10.7 0.0049 16.8 0.3 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 ETO05375.1 - 0.0001 22.3 8.9 1.5 8.9 0.1 5.3 5 0 0 5 5 5 1 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO05375.1 - 0.00042 20.1 11.5 5.6 6.8 0.3 5.2 3 2 1 5 5 5 2 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETO05375.1 - 0.00043 20.9 0.0 9.7 6.9 0.0 4.1 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO05375.1 - 0.001 19.3 13.3 0.88 10.1 0.0 7.5 6 1 2 8 8 8 1 Tetratricopeptide repeat PPR PF01535.20 ETO05375.1 - 0.0016 18.5 7.9 0.71 10.3 0.1 5.3 5 0 0 5 5 5 1 PPR repeat TPR_MalT PF17874.1 ETO05375.1 - 0.0067 15.8 0.0 0.022 14.1 0.0 1.8 1 1 1 2 2 2 1 MalT-like TPR region SPO22 PF08631.10 ETO05375.1 - 0.017 14.6 1.0 4.6 6.6 0.0 2.4 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like DUF627 PF04781.12 ETO05375.1 - 0.038 14.0 4.1 1.9 8.5 0.2 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF627) ANAPC3 PF12895.7 ETO05375.1 - 0.046 13.9 10.6 0.64 10.3 0.8 4.1 2 2 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 NSF PF02071.20 ETO05375.1 - 0.21 12.4 11.2 1.3e+02 4.1 0.1 5.8 5 0 0 5 5 5 0 Aromatic-di-Alanine (AdAR) repeat WD40 PF00400.32 ETO05376.1 - 9.4e-48 159.2 6.8 8e-10 39.2 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05376.1 - 2.9e-12 46.7 0.5 0.06 13.7 0.1 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05376.1 - 3.6e-08 32.7 0.4 0.097 11.6 0.0 4.0 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05376.1 - 5e-07 28.8 0.8 0.17 10.5 0.0 3.8 2 1 0 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05376.1 - 6.8e-07 28.9 0.2 0.002 17.5 0.1 2.6 1 1 2 3 3 3 3 WD40-like domain NHL PF01436.21 ETO05376.1 - 0.00085 19.2 0.1 0.078 13.1 0.0 2.9 3 0 0 3 3 3 1 NHL repeat Cytochrom_D1 PF02239.16 ETO05376.1 - 0.0013 17.4 0.5 0.0062 15.1 0.0 2.1 2 1 0 2 2 2 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO05376.1 - 0.0019 17.2 0.1 0.43 9.5 0.0 3.2 1 1 3 4 4 4 1 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO05376.1 - 0.0028 17.7 0.4 14 5.8 0.0 3.9 1 1 3 4 4 4 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO05376.1 - 0.013 14.3 3.0 0.49 9.1 0.3 3.4 2 1 2 4 4 4 0 Nup133 N terminal like B3_4 PF03483.17 ETO05376.1 - 0.06 13.0 0.0 0.26 11.0 0.0 2.0 1 1 1 2 2 2 0 B3/4 domain PLD_C PF12357.8 ETO05376.1 - 0.061 13.2 0.1 2.3 8.2 0.0 3.0 2 1 1 3 3 3 0 Phospholipase D C terminal DUF4672 PF15716.5 ETO05377.1 - 0.11 12.1 10.7 0.27 10.8 10.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) DEK_C PF08766.11 ETO05377.1 - 0.15 12.0 1.1 0.51 10.3 0.1 2.3 2 0 0 2 2 2 0 DEK C terminal domain zf-TRAF PF02176.18 ETO05379.1 - 0.00014 22.5 1.6 0.00014 22.5 1.6 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger DUF3584 PF12128.8 ETO05379.1 - 1.5 6.3 32.5 3.9 4.9 31.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) ATG16 PF08614.11 ETO05379.1 - 5.4 7.2 30.8 3.8 7.7 10.6 3.4 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DUF4239 PF14023.6 ETO05379.1 - 6.7 6.4 9.9 3.3 7.4 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4239) DUF4407 PF14362.6 ETO05379.1 - 9.2 5.5 21.2 22 4.3 20.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 ETO05380.1 - 9.9e-26 89.5 2.6 5.1e-08 33.5 0.1 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05380.1 - 7.8e-15 54.9 0.4 0.00068 19.9 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05380.1 - 2.5e-06 27.0 4.5 0.0022 17.4 0.4 2.2 2 0 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO05380.1 - 5.8e-05 21.8 0.1 0.0015 17.1 0.1 2.0 1 1 0 1 1 1 1 Cytochrome D1 heme domain VID27 PF08553.10 ETO05380.1 - 0.047 12.7 0.1 2.6 7.0 0.0 2.1 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain TFIIIC_delta PF12657.7 ETO05380.1 - 0.06 13.3 0.0 5.3 6.9 0.0 2.3 1 1 1 2 2 2 0 Transcription factor IIIC subunit delta N-term DUF3748 PF12566.8 ETO05380.1 - 0.2 11.6 0.1 9.2 6.2 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3748) Peptidase_S49_N PF08496.10 ETO05381.1 - 0.017 15.2 1.9 0.026 14.6 1.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal FlaE PF07559.14 ETO05381.1 - 0.16 12.5 0.8 0.25 11.9 0.0 1.7 2 0 0 2 2 2 0 Flagellar basal body protein FlaE VIT1 PF01988.19 ETO05381.1 - 0.3 10.9 0.9 0.43 10.4 0.9 1.2 1 0 0 1 1 1 0 VIT family MCM PF00493.23 ETO05382.1 - 0.00035 19.7 0.9 0.00053 19.2 0.1 1.6 2 0 0 2 2 2 1 MCM P-loop domain AAA_22 PF13401.6 ETO05382.1 - 0.0073 16.6 0.0 0.022 15.0 0.0 1.8 2 0 0 2 2 2 1 AAA domain Microtub_bd PF16796.5 ETO05382.1 - 0.012 15.6 0.3 0.015 15.3 0.3 1.4 1 1 0 1 1 1 0 Microtubule binding AAA PF00004.29 ETO05382.1 - 0.016 15.6 0.1 0.74 10.2 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ETO05382.1 - 0.05 14.1 0.1 0.084 13.4 0.0 1.4 1 1 0 1 1 1 0 ABC transporter IstB_IS21 PF01695.17 ETO05382.1 - 0.079 12.7 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein WW PF00397.26 ETO05384.1 - 1.1e-08 35.0 9.1 3.9e-06 26.9 3.1 2.6 2 0 0 2 2 2 2 WW domain SOG2 PF10428.9 ETO05384.1 - 0.069 12.4 22.1 0.078 12.2 22.1 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2147 PF09917.9 ETO05384.1 - 2.9 8.6 7.5 1.1 9.9 4.4 1.8 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2147) DUF1387 PF07139.11 ETO05384.1 - 6.7 6.3 17.4 8.6 6.0 17.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) AAA_9 PF12781.7 ETO05385.1 - 0.04 13.0 0.0 0.072 12.2 0.0 1.4 1 0 0 1 1 1 0 ATP-binding dynein motor region Atracotoxin PF05353.11 ETO05385.1 - 0.085 12.9 0.5 0.2 11.7 0.5 1.6 1 0 0 1 1 1 0 Delta Atracotoxin WD40 PF00400.32 ETO05386.1 - 6.9e-32 109.0 25.6 1.9e-05 25.3 0.1 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05386.1 - 2.1e-11 44.0 0.9 0.031 14.6 0.0 5.6 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05386.1 - 5.3e-07 28.7 8.6 1.3 7.6 0.0 5.9 1 1 5 6 6 6 5 Nucleoporin Nup120/160 TPR_2 PF07719.17 ETO05386.1 - 0.11 12.7 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05386.1 - 0.12 12.3 0.1 0.21 11.4 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO05386.1 - 0.16 12.1 0.1 0.38 10.9 0.1 1.6 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat PKcGMP_CC PF16808.5 ETO05387.1 - 0.02 14.7 1.1 0.038 13.9 1.1 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF5549 PF17703.1 ETO05387.1 - 0.88 9.2 4.2 1.2 8.8 4.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5549) FtsK_SpoIIIE_N PF12538.8 ETO05388.1 - 0.013 15.6 0.4 0.045 14.0 0.4 1.7 1 1 0 1 1 1 0 DNA transporter Ribosomal_S13 PF00416.22 ETO05388.1 - 0.039 14.3 0.0 0.058 13.8 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S13/S18 TAN PF11640.8 ETO05388.1 - 0.075 13.2 0.2 0.17 12.0 0.2 1.6 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair DNA_pol3_gamma3 PF12169.8 ETO05388.1 - 0.16 11.8 0.0 0.4 10.6 0.0 1.6 1 1 1 2 2 2 0 DNA polymerase III subunits gamma and tau domain III PUB PF09409.10 ETO05390.1 - 0.046 13.7 1.0 0.15 12.0 1.0 1.9 1 1 0 1 1 1 0 PUB domain Tubulin PF00091.25 ETO05392.1 - 1.1e-23 84.5 1.0 1.3e-23 84.3 0.9 1.3 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Gly_acyl_tr_C PF08444.10 ETO05393.1 - 0.15 12.4 3.2 0.17 12.1 1.2 2.1 1 1 2 3 3 3 0 Aralkyl acyl-CoA:amino acid N-acyltransferase, C-terminal region Exo_endo_phos_2 PF14529.6 ETO05394.1 - 2.8e-12 46.5 0.0 5.4e-12 45.6 0.0 1.5 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF2126 PF09899.9 ETO05394.1 - 0.0013 16.9 0.7 0.43 8.6 0.3 2.1 2 0 0 2 2 2 2 Putative amidoligase enzyme (DUF2126) Exo_endo_phos PF03372.23 ETO05394.1 - 0.025 14.1 0.0 0.033 13.7 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ku_C PF03730.14 ETO05394.1 - 0.13 13.0 9.9 0.093 13.4 7.2 2.2 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm FemAB PF02388.16 ETO05395.1 - 0.0081 15.1 4.2 0.011 14.6 4.2 1.2 1 0 0 1 1 1 1 FemAB family ERM PF00769.19 ETO05395.1 - 0.012 15.5 14.0 0.02 14.7 14.0 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Meth_synt_2 PF01717.18 ETO05395.1 - 0.012 15.0 1.2 0.012 15.0 1.2 1.9 1 1 0 2 2 2 0 Cobalamin-independent synthase, Catalytic domain KNTase_C PF07827.11 ETO05395.1 - 0.033 14.0 0.4 0.059 13.2 0.4 1.5 1 1 0 1 1 1 0 KNTase C-terminal domain ISG65-75 PF11727.8 ETO05395.1 - 0.12 11.5 9.2 0.13 11.4 6.7 1.9 1 1 1 2 2 2 0 Invariant surface glycoprotein DUF4449 PF14613.6 ETO05395.1 - 0.19 11.9 11.0 0.036 14.2 7.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4449) Sec34 PF04136.15 ETO05395.1 - 0.27 11.1 6.6 2.4 8.0 3.7 2.7 1 1 1 2 2 2 0 Sec34-like family DUF1664 PF07889.12 ETO05395.1 - 0.29 11.2 13.4 0.47 10.5 8.6 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF4472 PF14739.6 ETO05395.1 - 0.84 10.4 14.2 0.18 12.5 10.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) CENP-F_leu_zip PF10473.9 ETO05395.1 - 1.5 8.8 16.5 0.32 11.0 3.4 2.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Plk4_PB2 PF18409.1 ETO05395.1 - 2.5 8.8 6.8 1.9 9.2 4.6 1.9 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 V_ATPase_I PF01496.19 ETO05395.1 - 9 4.1 14.2 0.41 8.5 6.0 1.4 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF1492 PF07374.11 ETO05395.1 - 9.7 6.4 11.0 0.44 10.7 2.0 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1492) DUF2605 PF10792.9 ETO05396.1 - 0.012 15.5 1.3 0.11 12.4 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2605) DNA_pol3_beta_3 PF02768.15 ETO05397.1 - 0.11 12.3 2.0 0.13 12.1 0.6 1.7 2 0 0 2 2 2 0 DNA polymerase III beta subunit, C-terminal domain TLP-20 PF06088.11 ETO05397.1 - 0.35 10.7 7.7 0.75 9.7 7.8 1.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF5446 PF17522.2 ETO05398.1 - 1.5 9.0 4.6 0.87 9.8 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5446) SNF2_N PF00176.23 ETO05399.1 - 3.6e-44 150.9 0.0 4.4e-44 150.6 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain zf-C3HC4_2 PF13923.6 ETO05400.1 - 7.9e-09 35.2 19.0 7.9e-09 35.2 19.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO05400.1 - 4.3e-08 32.9 14.6 4.3e-08 32.9 14.6 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO05400.1 - 5.8e-08 32.5 19.3 5.8e-08 32.5 19.3 2.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO05400.1 - 9.4e-07 29.1 19.2 9.4e-07 29.1 19.2 2.3 2 0 0 2 2 1 1 Ring finger domain Prok-RING_4 PF14447.6 ETO05400.1 - 4.5e-06 26.4 16.3 4.5e-06 26.4 16.3 2.6 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ETO05400.1 - 8.3e-06 26.0 12.4 3.2e-05 24.1 12.4 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain Helicase_C PF00271.31 ETO05400.1 - 8.9e-06 26.0 0.1 1.9e-05 24.9 0.1 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain zf-RING_UBOX PF13445.6 ETO05400.1 - 0.00018 21.5 13.6 0.00018 21.5 13.6 2.6 2 1 0 2 2 2 1 RING-type zinc-finger U-box PF04564.15 ETO05400.1 - 0.00094 19.3 0.1 0.0035 17.5 0.0 2.0 2 0 0 2 2 2 1 U-box domain zf-C3HC4_4 PF15227.6 ETO05400.1 - 0.0012 19.0 18.5 0.0012 19.0 18.5 2.2 2 0 0 2 2 1 1 zinc finger of C3HC4-type, RING zf-RING_5 PF14634.6 ETO05400.1 - 0.0029 17.5 17.6 0.0029 17.5 17.6 2.9 1 1 1 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ETO05400.1 - 0.037 14.1 9.4 0.14 12.2 9.4 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger SNF2_N PF00176.23 ETO05400.1 - 0.04 12.6 0.1 0.09 11.5 0.1 1.5 1 0 0 1 1 1 0 SNF2 family N-terminal domain Rad50_zn_hook PF04423.14 ETO05400.1 - 0.78 9.6 11.4 0.12 12.2 3.5 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-C2H2_2 PF12756.7 ETO05400.1 - 1.9 8.9 12.5 0.74 10.2 9.0 2.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) WD40 PF00400.32 ETO05401.1 - 2.9e-11 43.7 0.1 5.6e-05 23.8 0.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05401.1 - 0.011 16.0 0.0 0.37 11.1 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO05402.1 - 6.9e-09 36.2 0.1 0.0003 21.5 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO05402.1 - 0.0042 16.1 0.4 0.13 11.2 0.1 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO05402.1 - 0.14 12.5 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain HSP70 PF00012.20 ETO05403.1 - 5.6e-06 24.8 0.0 0.00015 20.2 0.0 2.2 2 0 0 2 2 2 2 Hsp70 protein Hydantoinase_A PF01968.18 ETO05403.1 - 0.096 11.9 0.0 0.22 10.8 0.0 1.5 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase TelA PF05816.11 ETO05403.1 - 0.17 10.9 0.7 0.31 10.1 0.7 1.3 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) UQ_con PF00179.26 ETO05404.1 - 0.01 15.5 0.4 0.017 14.8 0.4 1.4 1 0 0 1 1 1 0 Ubiquitin-conjugating enzyme Chordopox_A30L PF06015.12 ETO05404.1 - 0.17 11.7 1.8 0.28 11.0 1.8 1.3 1 0 0 1 1 1 0 Chordopoxvirus A30L protein BcrAD_BadFG PF01869.20 ETO05405.1 - 0.026 14.0 0.0 0.034 13.6 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Takusan PF04822.13 ETO05407.1 - 0.0018 18.1 4.3 0.0029 17.4 4.3 1.4 1 0 0 1 1 1 1 Takusan Zeta_toxin PF06414.12 ETO05407.1 - 0.027 13.8 0.7 0.033 13.5 0.7 1.1 1 0 0 1 1 1 0 Zeta toxin DivIC PF04977.15 ETO05407.1 - 0.6 9.9 6.8 1.2 8.9 6.4 1.7 1 1 0 1 1 1 0 Septum formation initiator DUF5320 PF17253.2 ETO05407.1 - 4.3 8.5 5.4 1.9 9.6 2.9 1.7 2 1 0 2 2 2 0 Family of unknown function (DUF5320) bZIP_1 PF00170.21 ETO05407.1 - 9.7 6.4 16.8 1 9.5 12.0 2.0 2 1 0 2 2 2 0 bZIP transcription factor Sec20 PF03908.13 ETO05408.1 - 0.0082 16.0 0.5 0.025 14.5 0.5 1.9 1 1 0 1 1 1 1 Sec20 RAB3GAP2_C PF14656.6 ETO05408.1 - 0.0085 14.4 0.1 0.013 13.8 0.1 1.1 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit C-terminus MIEAP PF16026.5 ETO05408.1 - 0.071 13.3 3.6 0.28 11.4 3.6 1.9 1 1 0 1 1 1 0 Mitochondria-eating protein DUF3450 PF11932.8 ETO05409.1 - 0.00081 18.8 52.2 0.022 14.1 16.6 3.7 1 1 2 3 3 3 2 Protein of unknown function (DUF3450) KASH_CCD PF14662.6 ETO05409.1 - 0.011 15.6 32.2 0.011 15.6 32.2 4.4 3 1 1 4 4 4 0 Coiled-coil region of CCDC155 or KASH bZIP_1 PF00170.21 ETO05409.1 - 0.018 15.1 5.4 0.018 15.1 5.4 7.6 3 2 4 8 8 8 0 bZIP transcription factor Fez1 PF06818.15 ETO05409.1 - 3.3 8.1 64.4 0.19 12.1 28.6 3.2 2 1 1 3 3 3 0 Fez1 WD40 PF00400.32 ETO05410.1 - 1.5e-09 38.3 9.2 0.00044 21.0 0.3 3.5 3 2 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO05410.1 - 0.016 14.0 0.2 0.055 12.2 0.1 1.6 1 1 1 2 2 2 0 Nup133 N terminal like ANAPC4_WD40 PF12894.7 ETO05410.1 - 0.027 14.8 0.1 3.2 8.1 0.0 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Borrelia_P83 PF05262.11 ETO05410.1 - 0.053 12.0 0.0 0.067 11.7 0.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Nup160 PF11715.8 ETO05410.1 - 0.068 11.8 0.0 0.75 8.4 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Cdc6_C PF09079.11 ETO05411.1 - 0.00022 21.1 0.0 0.0004 20.3 0.0 1.5 1 0 0 1 1 1 1 CDC6, C terminal winged helix domain Penicillinase_R PF03965.16 ETO05411.1 - 0.019 15.3 0.4 0.061 13.7 0.0 1.9 2 0 0 2 2 2 0 Penicillinase repressor MarR PF01047.22 ETO05411.1 - 0.14 12.1 0.1 0.38 10.7 0.1 1.7 1 0 0 1 1 1 0 MarR family PCNP PF15473.6 ETO05417.1 - 0.0061 17.3 0.7 0.012 16.4 0.3 1.5 1 1 0 1 1 1 1 PEST, proteolytic signal-containing nuclear protein family Baculo_PEP_C PF04513.12 ETO05417.1 - 0.14 12.1 8.4 0.27 11.3 8.1 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ENTH PF01417.20 ETO05417.1 - 0.82 9.7 7.6 5 7.2 5.6 2.8 1 1 1 2 2 2 0 ENTH domain DUF883 PF05957.13 ETO05417.1 - 0.97 10.1 2.5 1.3 9.7 0.1 2.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 ETO05417.1 - 2.6 7.6 8.5 2.9 7.4 8.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mt_ATP-synt_D PF05873.12 ETO05417.1 - 2.9 7.7 12.0 1 9.2 8.4 1.9 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) CZB PF13682.6 ETO05418.1 - 0.1 13.0 0.0 0.29 11.6 0.0 1.8 1 0 0 1 1 1 0 Chemoreceptor zinc-binding domain DivIC PF04977.15 ETO05418.1 - 7 6.5 8.6 19 5.1 3.5 2.5 2 0 0 2 2 2 0 Septum formation initiator 14-3-3 PF00244.20 ETO05419.1 - 2.9e-17 62.9 30.1 6.7e-14 51.9 3.1 4.3 3 1 1 4 4 4 3 14-3-3 protein PhoLip_ATPase_C PF16212.5 ETO05421.1 - 6.3e-58 196.5 18.9 7.6e-58 196.2 18.9 1.0 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase_3 PF08282.12 ETO05421.1 - 0.00024 20.9 0.3 0.00038 20.3 0.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Inositol_P PF00459.25 ETO05422.1 - 2e-39 135.8 0.0 2.5e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Inositol monophosphatase family zf-MIZ PF02891.20 ETO05423.1 - 0.059 13.1 1.6 0.059 13.1 1.6 1.8 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger zf-C3HC4_2 PF13923.6 ETO05423.1 - 0.44 10.4 8.6 2.2 8.2 5.3 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Pkinase PF00069.25 ETO05424.1 - 3e-36 125.1 0.0 5.3e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05424.1 - 1.4e-18 67.2 0.0 2e-18 66.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO05424.1 - 0.0016 17.8 0.0 0.0026 17.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Arm PF00514.23 ETO05428.1 - 5.7e-08 32.5 0.1 0.0033 17.4 0.0 2.4 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 ETO05428.1 - 0.00065 19.2 0.9 0.0024 17.4 1.0 2.0 2 0 0 2 2 2 1 Atypical Arm repeat Cnd1 PF12717.7 ETO05428.1 - 0.0063 16.6 0.1 0.0093 16.0 0.1 1.3 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 Acetyltransf_7 PF13508.7 ETO05429.1 - 1.7e-05 25.2 0.7 0.0033 17.8 0.3 2.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO05429.1 - 0.0001 22.2 0.1 0.00038 20.4 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO05429.1 - 0.00038 20.7 0.1 1.3 9.3 0.0 2.4 2 0 0 2 2 2 2 Acetyltransferase (GNAT) family Apis_Csd PF11671.8 ETO05429.1 - 0.022 14.8 5.8 0.078 13.0 5.8 1.9 1 0 0 1 1 1 0 Complementary sex determiner protein DUF1974 PF09317.11 ETO05429.1 - 0.33 10.5 1.5 0.29 10.7 0.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1974) DDHD PF02862.17 ETO05429.1 - 0.62 10.2 4.7 0.56 10.3 2.2 2.1 2 0 0 2 2 2 0 DDHD domain Menin PF05053.13 ETO05429.1 - 4.1 5.6 8.0 7.4 4.8 8.0 1.4 1 0 0 1 1 1 0 Menin DUF3439 PF11921.8 ETO05429.1 - 8.6 6.4 13.9 28 4.7 13.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rxt3 PF08642.10 ETO05429.1 - 8.8 7.1 7.8 26 5.6 0.0 2.8 2 1 0 2 2 2 0 Histone deacetylation protein Rxt3 Secretin_N_2 PF07655.13 ETO05430.1 - 0.078 13.5 9.4 0.13 12.8 9.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Methyltransf_12 PF08242.12 ETO05430.1 - 0.1 13.4 2.2 0.18 12.6 2.2 1.4 1 0 0 1 1 1 0 Methyltransferase domain Menin PF05053.13 ETO05430.1 - 4.7 5.4 8.6 6 5.1 8.6 1.1 1 0 0 1 1 1 0 Menin DUF4079 PF13301.6 ETO05434.1 - 1.3 9.2 0.0 1.3 9.2 0.0 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF4079) Pkinase PF00069.25 ETO05436.1 - 1.3e-48 165.7 0.2 2.3e-48 164.8 0.2 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05436.1 - 1.6e-18 67.0 0.1 2.9e-18 66.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ETO05436.1 - 0.0041 16.8 0.2 0.69 9.5 0.0 2.3 2 0 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ETO05436.1 - 0.0081 15.8 0.8 0.3 10.7 0.8 2.2 1 1 0 1 1 1 1 RIO1 family Pox_ser-thr_kin PF05445.11 ETO05436.1 - 0.022 13.7 0.7 0.047 12.7 0.2 1.7 1 1 1 2 2 2 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 ETO05436.1 - 0.091 12.1 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO05436.1 - 0.12 12.2 0.0 0.2 11.5 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Annexin PF00191.20 ETO05437.1 - 7.3e-28 96.4 2.3 4.6e-11 42.6 0.0 4.3 4 0 0 4 4 4 4 Annexin Vac14_Fig4_bd PF11916.8 ETO05437.1 - 0.079 12.6 0.6 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding Erythro-docking PF09277.11 ETO05442.1 - 3.7 7.5 6.4 3 7.8 1.1 2.3 1 1 1 2 2 2 0 Erythronolide synthase, docking Nucleo_P87 PF07267.11 ETO05442.1 - 6.6 5.5 32.0 7.8 5.2 32.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MIEAP PF16026.5 ETO05446.1 - 4.7e-11 43.3 0.2 6.1e-11 42.9 0.2 1.1 1 0 0 1 1 1 1 Mitochondria-eating protein Membralin PF09746.9 ETO05447.1 - 0.021 13.9 2.0 0.025 13.6 2.0 1.0 1 0 0 1 1 1 0 Tumour-associated protein BBP2_2 PF10082.9 ETO05447.1 - 0.24 10.2 7.8 0.3 9.9 7.8 1.1 1 0 0 1 1 1 0 Putative beta-barrel porin 2 OMP_b-brl_3 PF14905.6 ETO05447.1 - 0.36 9.7 25.9 0.46 9.4 25.9 1.1 1 0 0 1 1 1 0 Outer membrane protein beta-barrel family CSRNP_N PF16019.5 ETO05448.1 - 0.71 9.8 9.6 0.95 9.3 9.6 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus OATP PF03137.20 ETO05448.1 - 0.97 7.6 1.7 0.97 7.6 1.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 ETO05448.1 - 4.1 7.1 8.9 6.9 6.4 8.9 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Membralin PF09746.9 ETO05448.1 - 7.1 5.6 6.7 7.8 5.4 6.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein FAM176 PF14851.6 ETO05448.1 - 9.9 5.8 12.5 2.1e+02 1.5 12.5 2.1 1 1 0 1 1 1 0 FAM176 family VPS13_C PF16909.5 ETO05449.1 - 8e-28 97.4 1.2 6.4e-24 84.7 0.0 3.3 2 1 1 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 ETO05449.1 - 2e-09 37.6 0.2 1e-08 35.4 0.0 2.2 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain AAA_23 PF13476.6 ETO05449.1 - 0.19 12.2 16.8 0.27 11.7 16.8 1.3 1 0 0 1 1 1 0 AAA domain GAGA_bind PF06217.12 ETO05449.1 - 5.3 7.2 11.5 7.2 6.8 11.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family SHR-BD PF06650.12 ETO05450.1 - 7.1e-05 22.3 0.7 0.00025 20.5 0.8 1.9 2 1 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 DUF3752 PF12572.8 ETO05450.1 - 0.0029 18.1 2.8 0.0029 18.1 2.8 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3752) Serglycin PF04360.12 ETO05450.1 - 0.0086 16.0 3.4 0.25 11.3 2.0 2.4 2 0 0 2 2 2 1 Serglycin Cnd1_N PF12922.7 ETO05450.1 - 6.5 6.6 9.2 0.79 9.6 4.6 1.8 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Pollen_allerg_1 PF01357.21 ETO05451.1 - 8.7e-06 25.7 2.9 0.00018 21.5 0.0 2.5 1 1 0 2 2 2 2 Pollen allergen Methyltransf_21 PF05050.12 ETO05453.1 - 0.00034 20.7 0.1 0.00089 19.3 0.1 1.8 2 0 0 2 2 2 1 Methyltransferase FkbM domain GPS PF01825.21 ETO05454.1 - 0.027 15.0 5.1 0.069 13.7 5.1 1.7 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif REJ PF02010.15 ETO05455.1 - 3.8e-07 29.3 1.0 0.00085 18.2 0.1 2.1 2 0 0 2 2 2 2 REJ domain FCH PF00611.23 ETO05456.1 - 7.2e-05 23.0 0.1 0.00012 22.3 0.1 1.4 1 0 0 1 1 1 1 Fes/CIP4, and EFC/F-BAR homology domain ATPase_2 PF01637.18 ETO05456.1 - 0.013 15.5 0.4 0.022 14.7 0.1 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea ArsR PF09824.9 ETO05456.1 - 0.051 13.2 0.1 0.09 12.4 0.1 1.4 1 1 0 1 1 1 0 ArsR transcriptional regulator Ribosomal_S8e PF01201.22 ETO05457.1 - 0.064 13.4 0.0 0.082 13.1 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S8e Kelch_1 PF01344.25 ETO05458.1 - 0.034 13.7 0.1 0.41 10.3 0.1 2.9 3 0 0 3 3 3 0 Kelch motif Apis_Csd PF11671.8 ETO05458.1 - 5.4 7.0 13.7 1.2 9.1 6.6 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein WD40 PF00400.32 ETO05459.1 - 2.7e-17 62.8 4.6 5.4e-08 33.4 0.4 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05459.1 - 0.013 15.8 0.0 0.24 11.7 0.0 2.1 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO05460.1 - 8.5e-17 61.2 7.8 5.3e-05 23.9 0.4 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05460.1 - 2.7e-06 27.6 0.9 0.032 14.5 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05460.1 - 2.1e-05 23.4 0.7 0.59 8.7 0.1 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 HECT PF00632.25 ETO05461.1 - 4.5e-54 184.0 0.1 5.4e-54 183.8 0.1 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Sec23_trunk PF04811.15 ETO05462.1 - 7.2e-05 22.5 0.0 0.00014 21.5 0.0 1.4 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain Lipase_GDSL PF00657.22 ETO05462.1 - 0.0018 18.3 5.2 0.0031 17.5 5.2 1.4 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase Menin PF05053.13 ETO05462.1 - 0.039 12.3 14.5 0.051 11.9 14.5 1.1 1 0 0 1 1 1 0 Menin dsRBD2 PF17842.1 ETO05462.1 - 0.048 13.9 11.9 0.18 12.0 0.5 2.3 1 1 1 2 2 2 0 Double-stranded RNA binding domain 2 SLC12 PF03522.15 ETO05462.1 - 0.1 11.6 12.2 0.14 11.2 12.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Pex2_Pex12 PF04757.14 ETO05462.1 - 0.15 11.6 0.5 0.26 10.9 0.5 1.3 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region Macoilin PF09726.9 ETO05462.1 - 0.18 10.3 15.1 0.22 10.0 15.1 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO05462.1 - 0.36 9.6 17.3 0.51 9.0 17.3 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO05462.1 - 0.41 8.9 14.2 0.56 8.4 14.2 1.2 1 0 0 1 1 1 0 CDC45-like protein EVI2A PF05399.11 ETO05462.1 - 1.2 8.7 18.0 1.8 8.1 18.0 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Hid1 PF12722.7 ETO05462.1 - 1.3 7.0 17.8 1.8 6.6 17.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein ALMT PF11744.8 ETO05462.1 - 3.3 6.4 13.3 4.5 6.0 13.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 ETO05463.1 - 0.14 13.0 0.0 0.27 12.2 0.0 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat ECH_1 PF00378.20 ETO05464.1 - 1.3e-27 96.7 0.6 1.6e-27 96.4 0.6 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO05464.1 - 4.1e-19 69.3 0.3 4.7e-19 69.1 0.3 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase WD40 PF00400.32 ETO05465.1 - 1.3e-46 155.6 14.8 7.3e-12 45.6 0.0 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05465.1 - 2.4e-13 50.2 0.1 0.00011 22.4 0.0 5.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05465.1 - 4.1e-11 42.4 0.0 0.0026 16.8 0.0 4.5 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO05465.1 - 1.1e-07 31.9 0.2 0.00056 19.9 0.0 2.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO05465.1 - 6.9e-06 25.0 1.1 0.87 8.2 0.0 4.1 2 1 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05465.1 - 1.7e-05 24.3 0.0 0.11 11.8 0.0 3.3 1 1 3 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO05465.1 - 0.00014 21.7 1.6 12 6.0 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO05465.1 - 0.0025 17.8 2.1 10 6.2 0.0 4.5 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region DUF4999 PF16390.5 ETO05465.1 - 0.051 13.8 0.3 12 6.2 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function Cytochrom_D1 PF02239.16 ETO05465.1 - 0.052 12.1 0.0 8.4 4.8 0.0 2.5 1 1 2 3 3 3 0 Cytochrome D1 heme domain DUF4072 PF13284.6 ETO05465.1 - 0.18 12.2 0.0 61 4.2 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4072) ABC_tran PF00005.27 ETO05467.1 - 0.0014 19.1 0.0 0.0016 19.0 0.0 1.5 1 1 0 1 1 1 1 ABC transporter Rad17 PF03215.15 ETO05467.1 - 0.019 14.9 0.1 0.071 13.0 0.1 2.0 1 1 0 1 1 1 0 Rad17 P-loop domain DUF5600 PF18150.1 ETO05470.1 - 6.9e-26 90.9 2.4 1.4e-25 89.9 2.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 ETO05470.1 - 3.8e-16 58.9 0.1 1.2e-15 57.3 0.0 1.9 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ETO05470.1 - 5.2e-05 22.5 1.6 0.00013 21.3 0.0 2.5 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 ETO05470.1 - 0.011 16.1 0.4 0.069 13.6 0.0 2.4 2 1 0 2 2 2 0 EF-hand domain pair DUF4698 PF15769.5 ETO05470.1 - 0.021 13.9 2.4 0.29 10.1 0.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4698) EF-hand_8 PF13833.6 ETO05470.1 - 0.042 13.7 0.7 0.3 11.0 0.2 2.5 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO05470.1 - 0.077 13.0 0.1 0.83 9.7 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 ETO05470.1 - 0.18 11.4 1.1 0.34 10.5 0.1 2.0 2 0 0 2 2 2 0 EF hand 2OG-FeII_Oxy_3 PF13640.6 ETO05471.1 - 6e-21 75.2 0.0 1.8e-20 73.6 0.0 1.9 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 ETO05471.1 - 7.4e-09 36.2 0.1 2.4e-08 34.5 0.1 2.0 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ETO05471.1 - 0.014 15.8 0.1 0.068 13.6 0.0 2.2 2 0 0 2 2 2 0 Putative 2OG-Fe(II) oxygenase BCL_N PF04714.13 ETO05471.1 - 0.034 14.2 0.1 0.11 12.5 0.1 1.9 1 0 0 1 1 1 0 BCL7, N-terminal conserver region DUF4472 PF14739.6 ETO05472.1 - 0.3 11.9 20.3 0.098 13.4 15.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) zf-CpG_bind_C PF12269.8 ETO05472.1 - 0.49 10.1 6.8 0.52 10.1 5.5 1.7 1 1 0 1 1 1 0 CpG binding protein zinc finger C terminal domain FapA PF03961.13 ETO05472.1 - 0.94 8.0 10.2 1.4 7.4 10.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A MDFI PF15316.6 ETO05472.1 - 4.2 7.4 9.5 1.5 8.9 1.1 2.1 2 0 0 2 2 2 0 MyoD family inhibitor TFIIF_alpha PF05793.12 ETO05473.1 - 1 7.9 37.5 1.7 7.2 37.5 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PBP1_TM PF14812.6 ETO05473.1 - 1.3 9.5 38.1 0.69 10.3 31.6 2.1 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Drc1-Sld2 PF11719.8 ETO05473.1 - 1.8 8.0 33.3 2 7.8 33.3 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein DUF4604 PF15377.6 ETO05473.1 - 5 7.5 33.2 6.2 7.2 33.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) PGA2 PF07543.12 ETO05473.1 - 8.8 6.3 33.4 13 5.8 32.2 1.7 1 1 0 1 1 1 0 Protein trafficking PGA2 Coilin_N PF15862.5 ETO05474.1 - 0.19 11.5 14.8 0.33 10.8 14.8 1.5 1 0 0 1 1 1 0 Coilin N-terminus DUF1682 PF07946.14 ETO05474.1 - 0.68 9.1 13.9 1 8.5 13.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Ureide_permease PF07168.11 ETO05474.1 - 3 6.5 6.1 3.9 6.1 6.1 1.2 1 0 0 1 1 1 0 Ureide permease GAGA_bind PF06217.12 ETO05474.1 - 5 7.3 15.4 6.3 7.0 15.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family O-antigen_lig PF13425.6 ETO05475.1 - 0.01 14.7 0.3 0.01 14.7 0.3 2.6 2 1 1 3 3 3 0 O-antigen ligase like membrane protein DndE PF08870.11 ETO05475.1 - 0.042 14.1 0.3 3.3 8.0 0.1 2.5 2 0 0 2 2 2 0 DNA sulphur modification protein DndE RNase_P_Rpp14 PF01900.19 ETO05476.1 - 1e-06 28.9 0.1 1.3e-06 28.6 0.1 1.1 1 0 0 1 1 1 1 Rpp14/Pop5 family RGS PF00615.19 ETO05477.1 - 0.0017 18.6 0.2 1.2 9.4 0.1 2.9 2 0 0 2 2 2 2 Regulator of G protein signaling domain Ribosomal_S25 PF03297.15 ETO05477.1 - 0.076 13.2 3.8 0.24 11.6 3.8 1.9 1 0 0 1 1 1 0 S25 ribosomal protein B56 PF01603.20 ETO05479.1 - 6.2e-11 41.9 0.7 1.3e-10 40.9 0.7 1.5 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) B56 PF01603.20 ETO05480.1 - 2.8e-45 155.0 0.4 4.9e-45 154.2 0.4 1.3 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Vac14_Fab1_bd PF12755.7 ETO05480.1 - 0.12 12.9 0.9 1.2 9.8 0.7 2.4 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region DUF2045 PF09741.9 ETO05481.1 - 0.0056 16.1 0.4 0.0082 15.6 0.4 1.2 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2045) EBV-NA3 PF05009.12 ETO05482.1 - 0.27 10.7 4.4 0.35 10.4 4.4 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) CDC45 PF02724.14 ETO05482.1 - 1.6 6.9 12.2 1.6 6.9 12.2 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO05482.1 - 1.7 8.0 19.8 1.9 7.9 19.8 1.1 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 ETO05482.1 - 3 7.1 14.4 3.9 6.7 14.4 1.2 1 0 0 1 1 1 0 NOA36 protein GRP PF07172.11 ETO05482.1 - 3.4 8.4 4.5 2.7 8.8 1.0 2.3 1 1 1 2 2 2 0 Glycine rich protein family DUF2457 PF10446.9 ETO05482.1 - 4.8 6.2 18.5 6.3 5.8 18.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRN3 PF05327.11 ETO05482.1 - 5.9 5.3 8.7 6 5.3 8.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4231 PF14015.6 ETO05484.1 - 0.036 14.5 5.0 25 5.4 0.0 6.6 7 0 0 7 7 7 0 Protein of unknown function (DUF4231) Telomere_reg-2 PF10193.9 ETO05484.1 - 0.14 12.6 0.7 11 6.5 0.0 4.4 6 0 0 6 6 6 0 Telomere length regulation protein DUF3566 PF12089.8 ETO05484.1 - 0.3 11.5 23.1 1.5 9.2 0.0 9.1 11 0 0 11 11 11 0 Transmembrane domain of unknown function (DUF3566) RasGEF PF00617.19 ETO05485.1 - 6e-18 65.7 2.1 1e-17 64.9 2.1 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF PF00617.19 ETO05486.1 - 3.8e-05 24.0 0.1 5.9e-05 23.3 0.1 1.3 1 1 0 1 1 1 1 RasGEF domain Trehalose_PPase PF02358.16 ETO05487.1 - 2.2e-33 115.3 0.2 1.1e-26 93.4 0.1 2.2 2 0 0 2 2 2 2 Trehalose-phosphatase CobT PF06213.12 ETO05487.1 - 0.0054 16.2 12.1 0.0054 16.2 12.1 2.1 2 0 0 2 2 2 1 Cobalamin biosynthesis protein CobT DUF3987 PF13148.6 ETO05487.1 - 0.033 13.2 3.0 0.066 12.2 3.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF3449 PF11931.8 ETO05487.1 - 0.28 11.0 9.5 7.6 6.3 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) CPSF100_C PF13299.6 ETO05487.1 - 0.32 11.2 12.7 0.12 12.5 6.7 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 ETO05487.1 - 0.57 8.4 13.8 0.17 10.1 10.6 1.6 2 0 0 2 2 2 0 CDC45-like protein Roughex PF06020.11 ETO05487.1 - 0.66 9.0 23.9 0.65 9.0 9.6 2.4 3 0 0 3 3 3 0 Drosophila roughex protein DUF2722 PF10846.8 ETO05487.1 - 0.89 8.4 20.9 0.32 9.9 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) SLC12 PF03522.15 ETO05487.1 - 1.1 8.2 11.2 0.14 11.2 4.6 2.0 2 0 0 2 2 2 0 Solute carrier family 12 Spt20 PF12090.8 ETO05487.1 - 1.3 8.6 27.7 2.2 7.8 9.8 2.2 2 0 0 2 2 2 0 Spt20 family Vfa1 PF08432.10 ETO05487.1 - 2.3 8.5 21.1 0.16 12.3 13.3 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF2076 PF09849.9 ETO05487.1 - 2.9 7.9 21.3 1.7 8.6 1.9 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Suf PF05843.14 ETO05487.1 - 4 7.3 12.3 1 9.3 1.3 2.3 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 ETO05487.1 - 4.2 7.3 5.4 1.8 8.6 0.8 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO05487.1 - 4.9 5.8 12.0 0.93 8.2 6.0 2.0 2 0 0 2 2 2 0 Presenilin RRN3 PF05327.11 ETO05487.1 - 5.6 5.4 12.2 10 4.5 12.2 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Peptidase_S49_N PF08496.10 ETO05487.1 - 5.9 6.9 9.3 18 5.4 6.4 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF2457 PF10446.9 ETO05487.1 - 6.4 5.8 22.0 0.24 10.5 15.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Zip PF02535.22 ETO05487.1 - 6.8 5.8 9.9 0.81 8.8 5.0 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter NPR3 PF03666.13 ETO05487.1 - 7.3 5.3 16.4 6.3 5.5 10.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CorA PF01544.18 ETO05489.1 - 1.8e-22 80.0 9.7 2.3e-16 60.0 2.1 2.7 2 1 1 3 3 3 2 CorA-like Mg2+ transporter protein DUF4666 PF15697.5 ETO05489.1 - 0.76 10.5 7.9 0.82 10.4 5.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) zf-C3HC4_3 PF13920.6 ETO05491.1 - 5.4e-05 23.0 8.9 8.5e-05 22.3 8.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) WWE PF02825.20 ETO05491.1 - 0.022 15.4 1.9 0.061 13.9 0.6 2.1 1 1 1 2 2 2 0 WWE domain Prok-RING_4 PF14447.6 ETO05491.1 - 0.2 11.5 9.3 0.32 10.9 9.3 1.3 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 DUF1967 PF09269.11 ETO05492.1 - 0.098 12.6 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1967) DUF1189 PF06691.11 ETO05493.1 - 0.031 13.9 5.8 0.02 14.5 3.4 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1189) RPN1_RPN2_N PF17781.1 ETO05494.1 - 4.4e-118 394.2 6.0 4.4e-118 394.2 6.0 1.7 2 0 0 2 2 2 1 RPN1/RPN2 N-terminal domain RPN1_C PF18051.1 ETO05494.1 - 2.6e-28 97.8 0.0 5.2e-28 96.8 0.0 1.5 1 0 0 1 1 1 1 26S proteasome non-ATPase regulatory subunit RPN1 C-terminal PC_rep PF01851.22 ETO05494.1 - 3.1e-16 58.9 13.5 0.00017 21.9 0.1 6.6 7 0 0 7 7 7 3 Proteasome/cyclosome repeat HEAT_2 PF13646.6 ETO05494.1 - 0.011 16.1 0.0 0.35 11.3 0.0 3.4 4 0 0 4 4 4 0 HEAT repeats CSG2 PF16965.5 ETO05494.1 - 0.024 13.6 0.1 0.88 8.4 0.0 2.4 2 0 0 2 2 2 0 Ceramide synthase regulator RPOL_N PF14700.6 ETO05494.1 - 0.056 12.8 2.0 0.64 9.4 0.1 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal DUF1406 PF07190.11 ETO05496.1 - 0.031 14.2 1.4 2.3 8.1 0.6 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1406) WD40 PF00400.32 ETO05497.1 - 1.5e-60 199.7 23.7 1.6e-09 38.2 0.1 8.9 9 0 0 9 9 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05497.1 - 2.5e-24 85.4 6.2 0.00077 19.7 0.0 7.9 2 1 6 8 8 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05497.1 - 1.7e-11 44.0 9.4 0.0011 18.3 0.0 5.4 4 1 2 6 6 6 4 WD40-like domain Ge1_WD40 PF16529.5 ETO05497.1 - 4.5e-10 39.0 1.5 0.048 12.6 0.1 5.6 2 1 5 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO05497.1 - 5.8e-08 31.7 1.4 2.9e-05 22.8 0.1 2.9 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO05497.1 - 1.4e-07 30.6 3.0 0.035 12.8 0.1 5.3 2 2 3 5 5 5 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO05497.1 - 7.5e-06 25.7 0.0 0.069 12.7 0.0 2.2 1 1 1 2 2 2 2 PQQ-like domain Kelch_4 PF13418.6 ETO05497.1 - 6.6e-05 22.8 0.1 0.011 15.8 0.1 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO05497.1 - 7.9e-05 22.8 7.3 0.81 10.1 0.0 6.1 6 1 1 7 7 6 2 Kelch motif Nucleoporin_N PF08801.11 ETO05497.1 - 0.00017 20.5 7.0 0.024 13.4 0.3 4.8 1 1 4 5 5 5 1 Nup133 N terminal like PQQ PF01011.21 ETO05497.1 - 0.0017 18.2 0.0 10 6.3 0.0 4.3 5 0 0 5 5 5 0 PQQ enzyme repeat Ricin_B_lectin PF00652.22 ETO05497.1 - 0.0061 16.8 0.6 0.18 12.1 0.2 3.3 1 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain DUF5570 PF17731.1 ETO05497.1 - 0.01 15.9 1.8 7.6 6.7 0.1 4.7 2 2 4 6 6 6 0 Family of unknown function (DUF5570) Kelch_5 PF13854.6 ETO05497.1 - 0.021 14.8 3.1 15 5.7 0.0 4.8 5 0 0 5 5 5 0 Kelch motif NHL PF01436.21 ETO05497.1 - 0.058 13.5 4.1 75 3.6 0.3 5.9 5 0 0 5 5 5 0 NHL repeat RicinB_lectin_2 PF14200.6 ETO05497.1 - 0.11 13.2 0.3 1.1 10.1 0.1 2.7 2 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like PD40 PF07676.12 ETO05497.1 - 0.19 11.7 7.3 29 4.8 0.1 5.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Kelch_1 PF01344.25 ETO05497.1 - 1.3 8.7 4.8 16 5.2 0.7 3.7 4 0 0 4 4 4 0 Kelch motif zf-C2H2_4 PF13894.6 ETO05498.1 - 4.6e-12 45.7 29.5 0.001 19.7 0.9 6.1 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO05498.1 - 1.7e-11 43.9 32.7 9.9e-06 25.7 1.3 6.3 5 1 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 ETO05498.1 - 0.00073 19.2 4.3 0.017 14.9 0.3 2.7 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 ETO05498.1 - 0.062 13.1 16.6 0.38 10.6 0.2 4.5 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-BED PF02892.15 ETO05498.1 - 0.064 13.3 21.1 0.16 12.0 3.1 3.9 3 1 1 4 4 4 0 BED zinc finger PRK PF00485.18 ETO05498.1 - 0.076 12.7 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family DUF4764 PF15961.5 ETO05498.1 - 0.12 11.0 1.0 0.19 10.4 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) zf-H2C2_2 PF13465.6 ETO05498.1 - 0.22 12.0 0.3 0.22 12.0 0.3 7.0 6 1 0 6 6 5 0 Zinc-finger double domain zf_C2H2_ZHX PF18387.1 ETO05498.1 - 0.27 10.9 10.2 0.32 10.7 0.7 2.8 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_jaz PF12171.8 ETO05498.1 - 0.3 11.4 25.8 1.3 9.4 2.3 5.5 5 0 0 5 5 5 0 Zinc-finger double-stranded RNA-binding ArgoMid PF16487.5 ETO05498.1 - 1.2 9.5 4.4 0.91 9.8 0.4 2.6 2 1 1 3 3 3 0 Mid domain of argonaute zf-met PF12874.7 ETO05498.1 - 1.3 9.5 24.9 2.6 8.6 0.1 6.1 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ETO05498.1 - 6.5 7.2 21.3 4.1 7.8 6.1 3.5 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) TPR_12 PF13424.6 ETO05499.1 - 4e-101 331.4 13.5 1.7e-21 76.2 0.0 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05499.1 - 5.2e-75 244.5 65.4 3.3e-11 42.5 2.3 11.6 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_10 PF13374.6 ETO05499.1 - 1.7e-69 228.0 14.4 2.9e-09 36.5 0.0 11.3 12 0 0 12 12 11 10 Tetratricopeptide repeat TPR_7 PF13176.6 ETO05499.1 - 8.3e-57 185.1 21.8 2.4e-07 30.3 0.2 11.5 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05499.1 - 1.1e-54 178.1 52.1 4.9e-08 32.5 1.2 11.7 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05499.1 - 3.4e-49 161.0 61.7 3.4e-07 30.0 2.7 11.8 11 0 0 11 11 11 11 Tetratricopeptide repeat TPR_17 PF13431.6 ETO05499.1 - 4.3e-25 86.2 26.8 0.0089 16.3 0.1 11.0 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_6 PF13174.6 ETO05499.1 - 7.5e-22 76.5 16.4 0.0018 18.8 0.0 12.0 13 0 0 13 13 11 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO05499.1 - 5.3e-21 74.0 55.6 0.0011 18.6 1.2 12.7 9 3 3 12 12 12 8 TPR repeat TPR_MalT PF17874.1 ETO05499.1 - 5.5e-21 75.3 0.0 1e-05 25.1 0.0 3.2 2 1 1 3 3 3 3 MalT-like TPR region TPR_14 PF13428.6 ETO05499.1 - 9e-19 66.6 0.0 0.84 10.6 0.0 10.4 9 1 1 10 10 10 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO05499.1 - 1.6e-16 60.6 0.1 9e-05 23.0 0.0 8.2 5 5 1 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO05499.1 - 2.9e-11 43.7 6.3 0.26 11.8 0.0 7.7 5 1 3 8 8 8 3 Tetratricopeptide repeat TPR_3 PF07720.12 ETO05499.1 - 2.4e-08 33.8 54.1 0.0052 16.7 0.5 9.4 9 0 0 9 9 9 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO05499.1 - 3.5e-07 29.6 9.2 0.026 14.0 0.0 6.5 7 0 0 7 7 7 1 SHNi-TPR PPR PF01535.20 ETO05499.1 - 4.6e-07 29.6 26.0 0.036 14.3 0.0 9.2 11 0 0 11 11 10 2 PPR repeat MIT PF04212.18 ETO05499.1 - 1.2e-06 28.5 29.7 2.7 8.2 0.1 9.4 9 0 0 9 9 9 2 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO05499.1 - 1.3e-05 25.4 28.5 0.09 13.0 1.1 7.0 1 1 6 8 8 8 5 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 ETO05499.1 - 0.093 12.4 12.3 0.83 9.3 0.6 5.6 3 1 1 5 5 5 0 26S proteasome subunit RPN7 DUF2225 PF09986.9 ETO05499.1 - 0.14 11.8 34.3 0.071 12.8 1.9 6.9 3 1 5 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF3856 PF12968.7 ETO05499.1 - 0.45 10.6 8.0 18 5.4 0.1 4.9 2 2 3 6 6 6 0 Domain of Unknown Function (DUF3856) SPO22 PF08631.10 ETO05499.1 - 0.74 9.2 12.8 19 4.6 0.1 5.3 2 2 1 5 5 5 0 Meiosis protein SPO22/ZIP4 like DUF5113 PF17140.4 ETO05499.1 - 1.8 8.4 51.4 0.18 11.6 0.3 10.6 9 3 4 13 13 12 0 Domain of unknown function (DUF5113) PPR_2 PF13041.6 ETO05499.1 - 3.2 8.0 19.3 3 8.1 0.1 6.4 7 0 0 7 7 6 0 PPR repeat family WD40 PF00400.32 ETO05500.1 - 5.3e-33 112.5 17.1 2e-06 28.4 0.1 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO05500.1 - 3.9e-13 48.9 3.7 0.00052 18.8 0.0 4.5 2 2 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05500.1 - 2.5e-12 46.9 3.1 0.016 15.5 0.1 5.3 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05500.1 - 8.6e-06 25.3 9.7 0.012 14.9 0.5 4.8 2 2 2 4 4 4 3 WD40-like domain zf-TRAF PF02176.18 ETO05502.1 - 6.1e-06 26.8 0.9 6.1e-06 26.8 0.9 2.8 1 1 1 2 2 2 1 TRAF-type zinc finger YabA PF06156.13 ETO05502.1 - 0.0051 17.4 23.3 0.38 11.4 7.6 2.9 1 1 1 2 2 2 2 Initiation control protein YabA Acetyltransf_11 PF13720.6 ETO05502.1 - 0.35 11.3 4.9 3 8.4 0.0 2.9 3 0 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 BAH PF01426.18 ETO05502.1 - 4.2 7.3 7.3 2.1 8.2 4.5 1.9 1 1 1 2 2 2 0 BAH domain JmjC PF02373.22 ETO05503.1 - 4.8e-17 62.4 1.7 1.5e-16 60.8 1.7 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ETO05503.1 - 1.6e-08 34.6 1.1 2.7e-08 33.9 1.1 1.2 1 0 0 1 1 1 1 Cupin-like domain Channel_Tsx PF03502.13 ETO05503.1 - 0.0047 16.7 0.6 0.0073 16.1 0.6 1.3 1 0 0 1 1 1 1 Nucleoside-specific channel-forming protein, Tsx Myticin-prepro PF10690.9 ETO05504.1 - 0.024 14.9 4.1 0.12 12.7 0.5 2.1 1 1 1 2 2 2 0 Myticin pre-proprotein from the mussel Lipase_3 PF01764.25 ETO05505.1 - 0.00024 21.0 0.0 0.00044 20.1 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) DUF3439 PF11921.8 ETO05505.1 - 0.002 18.1 1.5 0.0032 17.4 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO05505.1 - 0.068 11.2 1.0 0.081 10.9 1.0 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SMN PF06003.12 ETO05505.1 - 0.11 11.8 2.7 0.16 11.2 2.7 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DNA_pol_delta_4 PF04081.13 ETO05506.1 - 0.028 14.7 7.6 0.03 14.6 7.6 1.1 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 DUF3332 PF11810.8 ETO05506.1 - 0.13 11.9 3.3 0.13 11.9 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) DUF2828 PF11443.8 ETO05506.1 - 0.16 10.0 5.9 0.18 9.9 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3464 PF11947.8 ETO05506.1 - 0.19 11.4 3.5 0.19 11.4 3.5 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Connexin PF00029.19 ETO05506.1 - 0.22 11.3 4.5 0.21 11.3 4.5 1.1 1 0 0 1 1 1 0 Connexin Z1 PF10593.9 ETO05506.1 - 0.81 9.1 5.0 0.85 9.1 5.0 1.1 1 0 0 1 1 1 0 Z1 domain PDDEXK_9 PF08011.11 ETO05506.1 - 2.8 7.9 14.2 4.7 7.2 14.2 1.4 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily ABC_export PF16962.5 ETO05506.1 - 7.8 4.8 5.9 8 4.8 5.9 1.2 1 0 0 1 1 1 0 Putative ABC exporter WD40 PF00400.32 ETO05507.1 - 3.1e-56 186.1 16.9 1.8e-10 41.2 0.0 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05507.1 - 1.6e-20 73.2 2.6 0.0048 17.2 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05507.1 - 2.1e-13 49.8 0.8 0.045 12.4 0.1 5.1 2 2 3 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO05507.1 - 5.3e-13 48.6 1.9 0.045 12.7 0.0 5.9 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05507.1 - 1.7e-09 37.4 2.1 0.0041 16.5 0.0 3.3 2 1 2 4 4 4 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO05507.1 - 8e-07 27.9 0.1 0.00045 18.9 0.0 2.6 1 1 1 3 3 3 2 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO05507.1 - 0.00014 21.5 0.0 0.00033 20.3 0.0 1.6 1 1 0 1 1 1 1 PQQ-like domain PD40 PF07676.12 ETO05507.1 - 0.00061 19.7 2.8 3.9 7.5 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO05507.1 - 0.0042 17.0 0.0 6.8 6.8 0.0 3.6 3 0 0 3 3 3 1 PQQ enzyme repeat DUF5570 PF17731.1 ETO05507.1 - 0.0085 16.2 0.5 10 6.3 0.0 4.3 2 2 2 5 5 5 1 Family of unknown function (DUF5570) TolB_N PF04052.13 ETO05507.1 - 0.0087 16.2 0.1 11 6.2 0.0 3.5 3 1 0 3 3 3 1 TolB amino-terminal domain VID27 PF08553.10 ETO05507.1 - 0.014 14.5 0.1 0.9 8.5 0.0 2.5 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain Antimicrobial_7 PF08102.11 ETO05507.1 - 0.09 13.0 0.5 0.53 10.6 0.1 2.5 2 0 0 2 2 2 0 Scorpion antimicrobial peptide S10_plectin PF03501.15 ETO05508.1 - 8.9e-18 64.2 1.0 1.2e-17 63.7 1.0 1.2 1 0 0 1 1 1 1 Plectin/S10 domain Homeobox_KN PF05920.11 ETO05509.1 - 5.3e-15 55.0 1.4 5.3e-15 55.0 1.4 2.3 2 0 0 2 2 2 1 Homeobox KN domain Homeodomain PF00046.29 ETO05509.1 - 6.1e-10 38.8 1.4 1.6e-09 37.5 1.4 1.7 1 0 0 1 1 1 1 Homeodomain DUF2529 PF10740.9 ETO05510.1 - 0.091 12.4 1.8 1.2 8.8 0.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF2529) GMC_oxred_C PF05199.13 ETO05511.1 - 0.0074 16.8 0.0 0.0093 16.5 0.0 1.2 1 0 0 1 1 1 1 GMC oxidoreductase SIR4_SID PF16991.5 ETO05511.1 - 0.039 14.0 0.8 1.5 8.9 0.1 2.4 2 1 0 2 2 2 0 Sir4 SID domain Phage_TAC_12 PF12363.8 ETO05511.1 - 0.047 14.1 0.4 0.71 10.3 0.3 2.1 2 0 0 2 2 2 0 Phage tail assembly chaperone protein, TAC DivIC PF04977.15 ETO05511.1 - 0.25 11.2 3.1 0.43 10.4 3.1 1.3 1 0 0 1 1 1 0 Septum formation initiator PGM_PMM_I PF02878.16 ETO05512.1 - 1.1e-34 119.1 0.4 1.4e-30 105.8 0.2 2.5 1 1 1 2 2 2 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ETO05512.1 - 1.3e-17 64.3 0.0 1.3e-13 51.5 0.0 2.9 3 0 0 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II PGM_PMM_III PF02880.16 ETO05512.1 - 6.6e-06 26.3 0.0 1.6e-05 25.1 0.0 1.7 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III Kelch_5 PF13854.6 ETO05513.1 - 2e-05 24.5 3.1 0.023 14.7 0.4 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO05513.1 - 0.00072 19.7 6.2 1.5 9.2 0.1 4.4 3 1 1 4 4 4 2 Kelch motif N_Asn_amidohyd PF14736.6 ETO05513.1 - 0.066 12.4 0.2 10 5.1 0.0 2.3 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_1 PF01344.25 ETO05513.1 - 0.62 9.7 2.8 7.2 6.3 0.2 3.3 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO05514.1 - 1.5e-27 95.2 19.2 3e-07 31.0 0.8 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05514.1 - 1.6e-08 34.8 2.3 0.048 14.0 0.0 4.8 3 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05514.1 - 3.2e-07 29.4 5.8 0.026 13.2 0.1 4.5 2 2 2 5 5 5 3 Nucleoporin Nup120/160 BOP1NT PF08145.12 ETO05515.1 - 1e-48 166.6 1.4 1e-48 166.6 1.4 1.7 2 0 0 2 2 2 1 BOP1NT (NUC169) domain WD40 PF00400.32 ETO05515.1 - 6.2e-21 74.3 15.2 2.1e-10 41.0 0.4 6.5 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05515.1 - 2e-05 24.8 0.0 0.01 16.1 0.0 3.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Mif2_N PF15624.6 ETO05515.1 - 0.031 15.0 0.6 0.031 15.0 0.6 1.9 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Ge1_WD40 PF16529.5 ETO05515.1 - 0.053 12.5 0.0 0.14 11.1 0.0 1.6 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5137 PF17220.3 ETO05516.1 - 0.1 13.5 0.0 0.34 11.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF5137) YlbD_coat PF14071.6 ETO05516.1 - 4.1 7.7 8.2 20 5.4 0.0 3.7 4 1 0 4 4 4 0 Putative coat protein FAA_hydrolase_N PF09298.11 ETO05518.1 - 0.038 14.2 0.1 0.061 13.5 0.1 1.4 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal KleE PF17394.2 ETO05518.1 - 0.082 13.1 0.1 0.16 12.2 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized KleE stable inheritance protein DivIC PF04977.15 ETO05520.1 - 3.2e-05 23.6 1.7 3.2e-05 23.6 1.7 3.2 4 0 0 4 4 4 1 Septum formation initiator Lectin_N PF03954.14 ETO05520.1 - 0.005 16.6 0.3 0.013 15.3 0.3 1.6 1 0 0 1 1 1 1 Hepatic lectin, N-terminal domain RPW8 PF05659.11 ETO05520.1 - 0.0087 15.8 0.1 0.021 14.5 0.1 1.6 1 0 0 1 1 1 1 Arabidopsis broad-spectrum mildew resistance protein RPW8 Adaptin_binding PF10199.9 ETO05520.1 - 0.012 16.2 4.5 0.012 16.2 4.5 3.1 2 2 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 SesA PF17107.5 ETO05520.1 - 0.037 14.2 0.2 0.1 12.8 0.2 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases FAM76 PF16046.5 ETO05520.1 - 1.1 8.5 19.0 0.057 12.8 1.6 2.9 3 0 0 3 3 3 0 FAM76 protein DUF4637 PF15470.6 ETO05520.1 - 3.9 7.2 16.2 10 5.8 16.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Zip PF02535.22 ETO05520.1 - 8.8 5.4 10.6 3.8 6.6 7.8 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter PI3K_1B_p101 PF10486.9 ETO05520.1 - 9.4 3.9 12.2 0.12 10.1 4.5 1.6 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit BUD22 PF09073.10 ETO05520.1 - 9.7 5.4 26.9 0.6 9.4 10.8 3.5 4 0 0 4 4 4 0 BUD22 WD40 PF00400.32 ETO05522.1 - 4.8e-65 213.9 26.0 6.4e-10 39.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05522.1 - 4.3e-20 71.8 2.4 0.012 15.8 0.0 6.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05522.1 - 1.5e-13 50.5 1.3 0.023 13.7 0.0 6.5 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05522.1 - 1.7e-10 40.7 4.5 0.0025 17.2 0.1 3.8 1 1 3 4 4 4 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO05522.1 - 3.8e-08 32.3 0.6 0.0003 19.5 0.2 2.7 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO05522.1 - 7.8e-07 28.1 6.2 0.36 9.4 0.0 5.3 1 1 1 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO05522.1 - 0.0027 17.6 2.8 3.6 7.6 0.0 5.1 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO05522.1 - 0.0053 16.1 2.3 6.8 5.9 0.1 4.1 2 2 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO05522.1 - 0.072 11.8 0.6 30 3.2 0.0 3.6 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region nos_propeller PF18764.1 ETO05522.1 - 0.095 12.6 1.0 12 5.8 0.0 3.5 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat zf-TRAF PF02176.18 ETO05524.1 - 4.9e-06 27.1 2.0 2.5e-05 24.9 2.0 2.3 1 0 0 1 1 1 1 TRAF-type zinc finger BST2 PF16716.5 ETO05524.1 - 0.0018 18.9 1.0 1.5 9.5 0.0 2.5 2 0 0 2 2 2 2 Bone marrow stromal antigen 2 Fzo_mitofusin PF04799.13 ETO05524.1 - 0.37 10.3 1.9 0.64 9.6 0.6 1.9 2 0 0 2 2 2 0 fzo-like conserved region zf-MIZ PF02891.20 ETO05524.1 - 0.59 9.9 8.3 0.1 12.4 2.5 2.7 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger Sipho_Gp157 PF05565.11 ETO05526.1 - 0.1 12.6 4.9 0.39 10.7 1.5 2.2 2 0 0 2 2 2 0 Siphovirus Gp157 EMP24_GP25L PF01105.24 ETO05526.1 - 0.11 12.4 3.2 0.065 13.2 0.9 1.7 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD bZIP_1 PF00170.21 ETO05526.1 - 0.15 12.1 2.5 0.33 11.1 0.6 2.3 2 1 0 2 2 2 0 bZIP transcription factor WD40 PF00400.32 ETO05527.1 - 6.2e-41 137.6 24.2 2.3e-08 34.6 0.3 7.5 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05527.1 - 7.2e-14 51.9 1.6 0.032 14.5 0.1 5.7 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05527.1 - 1e-13 50.8 6.2 4.3e-05 22.4 0.6 4.3 2 1 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05527.1 - 2.3e-06 27.2 5.5 0.087 12.1 0.1 4.2 2 2 1 4 4 4 2 WD40-like domain RhoGEF PF00621.20 ETO05527.1 - 0.041 14.1 1.1 1.4 9.2 0.0 2.5 2 1 0 2 2 2 0 RhoGEF domain TetM_leader PF08076.11 ETO05527.1 - 0.35 10.7 3.9 0.89 9.4 0.4 3.3 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide Tox-HNH-HHH PF15637.6 ETO05527.1 - 2.5 8.3 5.1 0.83 9.8 0.4 2.2 2 0 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif EF-hand_1 PF00036.32 ETO05528.1 - 9e-24 81.2 15.4 3.1e-07 29.5 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO05528.1 - 5.8e-20 69.5 10.3 6.8e-05 22.5 0.7 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ETO05528.1 - 1.1e-19 70.7 13.6 6.4e-13 49.0 3.7 3.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO05528.1 - 4.4e-14 51.2 15.4 0.00015 21.1 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO05528.1 - 8.9e-13 47.9 16.0 4.1e-09 36.1 1.3 4.1 1 1 3 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO05528.1 - 0.013 15.8 6.9 0.081 13.3 0.2 2.9 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Roughex PF06020.11 ETO05528.1 - 0.051 12.7 3.9 3.1 6.8 4.7 2.1 2 0 0 2 2 2 0 Drosophila roughex protein EF-hand_10 PF14788.6 ETO05528.1 - 6.1 6.8 8.2 7.7 6.5 1.0 4.0 4 1 1 5 5 5 0 EF hand DUF2272 PF10030.9 ETO05529.1 - 0.00065 19.5 0.4 0.22 11.2 0.1 2.5 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_4 PF13418.6 ETO05529.1 - 0.14 12.2 0.0 1.6 8.8 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain WD40 PF00400.32 ETO05530.1 - 8.4e-28 96.1 3.8 3.8e-09 37.0 0.0 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05530.1 - 2.9e-08 33.9 0.2 0.036 14.4 0.0 3.3 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05530.1 - 4e-06 25.8 0.5 0.022 13.4 0.0 2.5 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05530.1 - 2.5e-05 23.8 1.5 4.7e-05 22.9 1.0 1.6 1 1 1 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 ETO05530.1 - 2.6e-05 23.3 0.7 0.047 12.6 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO05530.1 - 0.01 14.6 1.5 0.81 8.4 0.1 2.5 1 1 1 2 2 2 0 Nup133 N terminal like HARP PF07443.13 ETO05530.1 - 0.067 12.8 0.3 15 5.3 0.0 2.7 2 1 1 3 3 3 0 HepA-related protein (HARP) DUF1854 PF08909.11 ETO05530.1 - 0.12 12.2 0.2 0.53 10.1 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1854) Bet_v_1 PF00407.19 ETO05530.1 - 0.51 10.2 2.9 10 6.0 0.3 2.7 2 1 1 3 3 3 0 Pathogenesis-related protein Bet v I family WD40 PF00400.32 ETO05531.1 - 6.6e-16 58.4 15.6 1.7e-07 31.8 0.1 5.1 5 3 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO05531.1 - 3.9e-05 22.5 4.0 0.26 9.9 0.1 3.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05531.1 - 0.00035 20.8 0.7 4.8 7.5 0.0 3.7 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO05531.1 - 0.01 14.6 1.7 0.52 9.0 0.0 2.3 1 1 1 2 2 2 0 Nup133 N terminal like ArlS_N PF18719.1 ETO05531.1 - 0.34 11.1 2.4 7.6 6.8 0.1 2.5 1 1 0 2 2 2 0 ArlS sensor domain WD40 PF00400.32 ETO05532.1 - 5.1e-43 144.2 23.2 6.7e-08 33.1 0.1 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05532.1 - 1.8e-14 53.8 0.5 0.0039 17.5 0.0 5.9 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05532.1 - 4.3e-11 42.2 3.1 0.027 13.1 0.3 5.6 1 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05532.1 - 6.9e-06 25.6 7.5 0.17 11.2 0.0 4.4 2 2 2 4 4 4 3 WD40-like domain SH2 PF00017.24 ETO05532.1 - 0.083 13.0 0.1 17 5.6 0.0 2.8 3 0 0 3 3 3 0 SH2 domain fn3_PAP PF17808.1 ETO05532.1 - 0.084 13.0 0.8 5.6 7.1 0.9 2.9 3 1 1 4 4 4 0 Fn3-like domain from Purple Acid Phosphatase Kazal_2 PF07648.15 ETO05532.1 - 0.35 11.0 4.2 0.37 11.0 0.4 2.6 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain NUP214 PF16755.5 ETO05533.1 - 0.033 13.4 0.5 0.039 13.2 0.5 1.1 1 0 0 1 1 1 0 Nucleoporin or Nuclear pore complex subunit NUP214=Nup159 HR1 PF02185.16 ETO05533.1 - 0.058 13.5 4.3 0.091 12.9 0.4 2.3 2 0 0 2 2 2 0 Hr1 repeat DUF1644 PF07800.12 ETO05535.1 - 0.028 14.5 3.2 0.047 13.7 3.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) zf-C3HC4_3 PF13920.6 ETO05535.1 - 0.076 12.9 4.7 0.41 10.5 4.7 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO05535.1 - 0.12 12.7 3.3 2.2 8.7 3.7 2.5 1 1 1 2 2 2 0 RING-like domain MMR_HSR1 PF01926.23 ETO05536.1 - 3.6e-26 91.5 0.1 7.8e-26 90.4 0.1 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO05536.1 - 3.6e-12 46.1 0.0 6.4e-12 45.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ETO05536.1 - 4.5e-07 30.1 0.5 0.02 15.0 0.0 2.8 3 0 0 3 3 3 2 Dynamin family RsgA_GTPase PF03193.16 ETO05536.1 - 4.2e-05 23.5 0.0 0.00019 21.4 0.0 2.0 1 1 1 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ETO05536.1 - 7e-05 22.2 0.0 0.00012 21.5 0.0 1.4 1 0 0 1 1 1 1 AIG1 family SRPRB PF09439.10 ETO05536.1 - 0.0019 17.7 0.0 0.004 16.6 0.0 1.5 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ETO05536.1 - 0.013 15.7 0.2 0.14 12.4 0.0 2.7 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETO05536.1 - 0.016 15.8 0.8 0.033 14.7 0.1 2.1 2 1 0 2 2 2 0 ABC transporter TniB PF05621.11 ETO05536.1 - 0.022 14.1 0.0 0.033 13.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein GTP_EFTU PF00009.27 ETO05536.1 - 0.04 13.5 0.1 1.7 8.1 0.0 3.2 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain Ras PF00071.22 ETO05536.1 - 0.077 12.6 0.0 0.23 11.1 0.0 1.9 2 0 0 2 2 2 0 Ras family AAA_23 PF13476.6 ETO05536.1 - 0.61 10.6 5.7 10 6.5 5.7 2.3 1 1 0 1 1 1 0 AAA domain Actin PF00022.19 ETO05537.1 - 3.9e-77 259.6 0.0 1.9e-76 257.3 0.0 1.8 1 1 0 1 1 1 1 Actin Actin PF00022.19 ETO05538.1 - 9.5e-24 83.7 0.0 1.2e-23 83.4 0.0 1.1 1 0 0 1 1 1 1 Actin Kelch_5 PF13854.6 ETO05539.1 - 0.1 12.6 3.7 0.58 10.2 0.0 3.6 4 1 1 5 5 5 0 Kelch motif BDHCT_assoc PF16204.5 ETO05539.1 - 0.81 9.3 5.2 0.29 10.8 0.1 2.6 2 1 1 3 3 3 0 BDHCT-box associated domain on Bloom syndrome protein Zeta_toxin PF06414.12 ETO05542.1 - 0.064 12.5 0.0 0.098 11.9 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin BrkDBD PF09607.10 ETO05543.1 - 0.011 15.5 1.4 0.74 9.6 0.5 2.8 2 0 0 2 2 2 0 Brinker DNA-binding domain BLOC1_2 PF10046.9 ETO05543.1 - 0.12 12.7 5.8 0.93 9.8 0.3 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 NPV_P10 PF05531.12 ETO05543.1 - 0.33 11.4 4.2 7.4 7.1 0.0 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FlxA PF14282.6 ETO05543.1 - 2 8.5 10.0 0.71 9.9 3.3 2.7 3 0 0 3 3 3 0 FlxA-like protein Apolipoprotein PF01442.18 ETO05544.1 - 8.3e-05 22.5 10.2 0.00013 22.0 10.2 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain AI-2E_transport PF01594.16 ETO05544.1 - 0.017 14.3 7.0 0.03 13.5 7.0 1.4 1 1 0 1 1 1 0 AI-2E family transporter Fez1 PF06818.15 ETO05544.1 - 0.04 14.4 17.9 0.066 13.7 17.9 1.4 1 0 0 1 1 1 0 Fez1 UPF0242 PF06785.11 ETO05544.1 - 0.052 13.7 26.8 0.064 13.4 25.3 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ETO05544.1 - 0.088 11.9 22.7 0.12 11.5 22.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 kleA_kleC PF17383.2 ETO05544.1 - 0.24 11.7 2.1 1 9.8 0.7 2.2 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A Tropomyosin_1 PF12718.7 ETO05544.1 - 0.27 11.4 22.4 0.26 11.4 21.2 1.6 1 1 0 1 1 1 0 Tropomyosin like NPV_P10 PF05531.12 ETO05544.1 - 0.43 11.1 18.2 1.8 9.1 7.0 2.8 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF4795 PF16043.5 ETO05544.1 - 0.43 10.2 20.8 0.72 9.4 20.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Exonuc_VII_L PF02601.15 ETO05544.1 - 0.43 10.1 15.4 0.59 9.7 15.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1640 PF07798.11 ETO05544.1 - 0.45 10.5 24.2 1.7 8.7 24.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Spc7 PF08317.11 ETO05544.1 - 0.65 8.8 25.6 0.86 8.4 25.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FliT PF05400.13 ETO05544.1 - 0.7 10.7 7.1 5.2 8.0 6.7 2.2 1 1 1 2 2 2 0 Flagellar protein FliT FAM76 PF16046.5 ETO05544.1 - 0.71 9.2 22.8 0.089 12.1 18.3 1.7 1 1 0 1 1 1 0 FAM76 protein DUF848 PF05852.11 ETO05544.1 - 3.9 7.6 14.5 2.3 8.3 11.1 2.1 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Spc29 PF17082.5 ETO05544.1 - 8 6.2 21.1 0.33 10.8 5.9 2.1 1 1 1 2 2 2 0 Spindle Pole Component 29 Pkinase PF00069.25 ETO05545.1 - 5.6e-07 29.2 0.2 2.2e-06 27.3 0.2 1.8 1 1 0 1 1 1 1 Protein kinase domain IF3_N PF05198.16 ETO05545.1 - 0.11 12.8 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain Peptidase_C14 PF00656.22 ETO05546.1 - 2.9e-17 63.5 1.2 3.8e-17 63.1 1.2 1.2 1 0 0 1 1 1 1 Caspase domain NblA PF04485.12 ETO05546.1 - 0.011 16.1 0.1 0.022 15.1 0.1 1.5 1 0 0 1 1 1 0 Phycobilisome degradation protein nblA WD40 PF00400.32 ETO05547.1 - 2.2e-12 47.3 0.3 0.00017 22.3 0.1 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05547.1 - 0.012 15.9 0.0 2.5 8.5 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05547.1 - 0.022 13.4 0.1 0.29 9.7 0.0 2.1 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Sua5_yciO_yrdC PF01300.18 ETO05549.1 - 0.016 14.7 0.8 0.023 14.2 0.8 1.2 1 0 0 1 1 1 0 Telomere recombination zf-C2H2_7 PF15269.6 ETO05552.1 - 0.18 11.9 0.4 0.37 10.9 0.0 1.7 2 0 0 2 2 2 0 Zinc-finger MatE PF01554.18 ETO05554.1 - 0.02 14.6 12.6 0.23 11.1 12.6 2.5 1 1 0 1 1 1 0 MatE FSAP_sig_propep PF03032.15 ETO05554.1 - 0.38 10.8 2.6 1.1 9.4 2.6 1.8 1 0 0 1 1 1 0 Frog skin active peptide family signal and propeptide WD40 PF00400.32 ETO05556.1 - 2.6e-25 88.2 9.3 9.2e-11 42.1 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05556.1 - 8.8e-10 38.8 0.4 0.0016 18.7 0.0 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05556.1 - 9.5e-06 24.8 0.0 0.075 12.0 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05556.1 - 0.00074 18.3 0.3 0.37 9.4 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05556.1 - 0.0033 16.8 0.0 2.2 7.6 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO05556.1 - 0.0096 15.8 0.1 4.1 7.5 0.0 2.6 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO05556.1 - 0.044 12.3 0.2 0.54 8.7 0.2 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain PQQ PF01011.21 ETO05556.1 - 0.066 13.2 0.0 11 6.1 0.0 3.2 3 0 0 3 3 3 0 PQQ enzyme repeat DUF5570 PF17731.1 ETO05556.1 - 0.079 13.1 0.3 13 5.9 0.1 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO05556.1 - 0.092 12.4 0.5 13 5.6 0.0 2.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF4407 PF14362.6 ETO05557.1 - 0.88 8.9 17.2 0.35 10.2 12.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) GTP-bdg_M PF16360.5 ETO05557.1 - 6.4 7.4 9.9 22 5.7 2.4 2.8 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region TPR_19 PF14559.6 ETO05558.1 - 9.7e-12 45.2 0.0 2.2e-06 28.1 0.0 4.2 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO05558.1 - 5.8e-06 26.7 0.0 0.22 12.4 0.0 4.8 4 1 1 5 5 5 1 Tetratricopeptide repeat Coatomer_E PF04733.14 ETO05558.1 - 0.00035 20.1 0.7 0.00075 19.0 0.0 1.8 2 0 0 2 2 2 1 Coatomer epsilon subunit TPR_15 PF13429.6 ETO05558.1 - 0.00038 19.8 0.1 0.011 14.9 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETO05558.1 - 0.00039 20.2 0.1 0.001 18.8 0.0 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 ETO05558.1 - 0.00058 20.3 1.1 20 6.1 0.0 5.8 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO05558.1 - 0.00064 19.9 0.1 0.025 14.8 0.0 3.3 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETO05558.1 - 0.00086 19.2 7.5 15 6.0 0.0 5.7 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO05558.1 - 0.046 14.4 0.1 15 6.4 0.0 3.6 3 2 1 4 4 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ETO05558.1 - 0.054 13.8 0.3 0.19 12.1 0.0 2.0 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4616 PF15394.6 ETO05558.1 - 0.088 11.8 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4616) GST_C_3 PF14497.6 ETO05559.1 - 2.2e-12 47.0 0.0 3.3e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO05559.1 - 1.2e-06 28.6 0.0 2.4e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETO05559.1 - 0.00015 22.0 0.0 0.00031 21.0 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETO05559.1 - 0.046 13.7 0.0 0.073 13.1 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain PapG_N PF03627.13 ETO05560.1 - 0.0063 16.2 0.2 0.0063 16.2 0.2 1.1 1 0 0 1 1 1 1 PapG carbohydrate binding domain Coilin_N PF15862.5 ETO05561.1 - 0.26 11.1 12.4 0.32 10.8 12.4 1.2 1 0 0 1 1 1 0 Coilin N-terminus DUF3408 PF11888.8 ETO05561.1 - 0.27 11.4 10.7 0.29 11.3 10.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) RNA_pol_Rpc4 PF05132.14 ETO05561.1 - 1.6 9.2 10.4 1.6 9.2 10.4 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DDHD PF02862.17 ETO05561.1 - 2.3 8.3 6.6 2.4 8.3 6.6 1.0 1 0 0 1 1 1 0 DDHD domain PBP_sp32 PF07222.12 ETO05561.1 - 3.7 6.9 11.5 3.7 6.9 11.5 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF4337 PF14235.6 ETO05561.1 - 3.7 7.6 10.4 3.9 7.6 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Presenilin PF01080.17 ETO05561.1 - 4.3 6.0 6.3 3.9 6.1 6.3 1.0 1 0 0 1 1 1 0 Presenilin Folate_carrier PF01770.18 ETO05561.1 - 6.2 5.4 4.1 5.7 5.6 4.1 1.0 1 0 0 1 1 1 0 Reduced folate carrier Nup88 PF10168.9 ETO05562.1 - 0.08 10.8 6.0 0.09 10.6 6.0 1.0 1 0 0 1 1 1 0 Nuclear pore component Retinal PF15449.6 ETO05563.1 - 0.71 7.6 35.0 0.034 11.9 9.4 2.1 1 1 1 2 2 2 0 Retinal protein CDC45 PF02724.14 ETO05564.1 - 0.36 9.1 13.8 0.39 8.9 13.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO05564.1 - 0.37 9.0 15.8 0.44 8.7 15.8 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ETO05564.1 - 1.4 8.2 19.4 1.8 7.8 19.4 1.3 1 0 0 1 1 1 0 NOA36 protein LAP1C PF05609.12 ETO05564.1 - 1.4 7.9 16.3 1.7 7.6 16.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2457 PF10446.9 ETO05564.1 - 2.3 7.3 18.7 3.2 6.8 18.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SLC12 PF03522.15 ETO05564.1 - 4.3 6.2 12.9 5.2 6.0 12.9 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ETO05564.1 - 4.8 5.8 16.9 6.1 5.5 16.9 1.3 1 0 0 1 1 1 0 Presenilin YMF19 PF02326.15 ETO05566.1 - 0.013 16.2 2.2 0.013 16.2 2.2 1.6 2 0 0 2 2 2 0 Plant ATP synthase F0 ETRAMP PF09716.10 ETO05566.1 - 0.12 12.5 3.0 0.64 10.1 2.8 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) E1_4HB PF16191.5 ETO05567.1 - 0.005 17.0 0.1 0.53 10.5 0.0 3.2 3 0 0 3 3 3 1 Ubiquitin-activating enzyme E1 four-helix bundle DENN PF02141.21 ETO05568.1 - 2.1e-47 161.5 2.8 2.1e-47 161.5 2.8 3.8 4 0 0 4 4 4 1 DENN (AEX-3) domain dDENN PF03455.19 ETO05568.1 - 6.6e-14 51.6 1.2 1.8e-13 50.2 1.2 1.9 1 0 0 1 1 1 1 dDENN domain Collagen PF01391.18 ETO05568.1 - 0.011 15.4 4.2 0.021 14.6 4.2 1.3 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Hexapep PF00132.24 ETO05568.1 - 1.5 8.7 5.5 3.3 7.6 5.5 1.6 1 0 0 1 1 1 0 Bacterial transferase hexapeptide (six repeats) DUF1664 PF07889.12 ETO05568.1 - 4 7.5 23.4 0.076 13.1 4.4 5.4 5 0 0 5 5 5 0 Protein of unknown function (DUF1664) PKcGMP_CC PF16808.5 ETO05569.1 - 5.5e-05 22.9 5.7 0.026 14.4 0.6 3.1 2 0 0 2 2 2 2 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4094 PF13334.6 ETO05569.1 - 9.3 6.7 9.0 0.37 11.2 0.8 2.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4094) Caskin-tail PF16632.5 ETO05570.1 - 0.11 12.9 2.5 1.9 8.9 0.6 2.9 3 0 0 3 3 3 0 C-terminal region of Caskin WD40 PF00400.32 ETO05572.1 - 3.3e-07 30.9 4.8 0.00014 22.6 0.5 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF4468 PF14730.6 ETO05573.1 - 0.049 13.9 0.1 0.097 13.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4468) with TBP-like fold Cnd1 PF12717.7 ETO05574.1 - 1.6e-05 25.0 4.9 0.00035 20.6 1.2 3.5 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 RHD3 PF05879.12 ETO05574.1 - 0.0024 16.1 1.1 0.0034 15.6 0.6 1.4 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) DNA_ligase_A_N PF04675.14 ETO05574.1 - 0.0032 17.8 1.3 0.008 16.5 1.3 1.7 1 1 0 1 1 1 1 DNA ligase N terminus RTP1_C1 PF10363.9 ETO05574.1 - 0.0034 17.5 0.2 9 6.5 0.0 3.6 1 1 2 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 LuxT_C PF18285.1 ETO05574.1 - 0.22 12.1 2.4 21 5.7 0.0 3.2 2 1 1 3 3 3 0 Tetracycline repressor LuxT C-terminal domain CART PF06373.11 ETO05574.1 - 1.7 8.9 5.5 33 4.8 0.2 4.0 4 0 0 4 4 4 0 Cocaine and amphetamine regulated transcript protein (CART) NACHT PF05729.12 ETO05575.1 - 3.9e-17 62.7 0.0 3.8e-16 59.5 0.0 2.6 2 1 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 ETO05575.1 - 8.7e-05 23.0 0.0 0.00026 21.4 0.0 1.9 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO05575.1 - 0.087 13.1 0.1 0.9 9.8 0.0 2.6 2 0 0 2 2 2 0 AAA domain DUF3323 PF11796.8 ETO05575.1 - 0.14 12.0 0.4 6.2 6.6 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function N-terminus (DUF3323) Secretin_N_2 PF07655.13 ETO05575.1 - 0.88 10.2 19.3 1.1 9.8 4.2 4.3 4 0 0 4 4 4 0 Secretin N-terminal domain TERB2 PF15101.6 ETO05576.1 - 0.01 15.9 1.4 0.014 15.5 1.4 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RNA_polI_A34 PF08208.11 ETO05576.1 - 0.044 13.9 9.9 0.046 13.8 9.9 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RNA_pol_3_Rpc31 PF11705.8 ETO05576.1 - 0.069 13.4 11.1 0.092 13.0 11.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DDHD PF02862.17 ETO05576.1 - 0.081 13.1 0.7 0.09 12.9 0.7 1.1 1 0 0 1 1 1 0 DDHD domain Peptidase_S49_N PF08496.10 ETO05576.1 - 0.11 12.5 6.5 0.11 12.6 5.9 1.3 1 1 0 1 1 1 0 Peptidase family S49 N-terminal RNA_pol_Rpc4 PF05132.14 ETO05576.1 - 0.12 12.9 2.0 0.15 12.4 2.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETO05576.1 - 0.16 10.3 4.8 0.17 10.2 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein LYRIC PF15686.5 ETO05576.1 - 0.35 10.4 12.7 0.4 10.2 12.7 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DUF1682 PF07946.14 ETO05576.1 - 0.36 10.0 7.3 0.54 9.4 7.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Phage_Gp23 PF10669.9 ETO05576.1 - 0.38 11.1 9.2 0.21 11.9 6.7 1.9 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Presenilin PF01080.17 ETO05576.1 - 0.54 9.0 1.3 0.51 9.1 1.3 1.1 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ETO05576.1 - 0.56 8.3 13.9 0.64 8.1 13.9 1.0 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 ETO05576.1 - 0.56 9.4 4.8 0.56 9.4 4.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sec62 PF03839.16 ETO05576.1 - 1.1 8.7 4.5 1.3 8.4 4.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 ETO05576.1 - 1.7 8.3 4.4 2.1 8.0 4.4 1.2 1 0 0 1 1 1 0 Connexin MDM10 PF12519.8 ETO05576.1 - 3 6.6 6.9 3.6 6.3 6.9 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 MAP17 PF15807.5 ETO05576.1 - 6.6 7.0 7.7 11 6.3 7.7 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 WD40 PF00400.32 ETO05577.1 - 4.5e-45 150.7 11.2 7.5e-13 48.8 0.4 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05577.1 - 5e-18 65.2 1.1 0.00033 20.9 0.0 4.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO05577.1 - 1.1e-07 31.9 0.1 0.0052 16.7 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO05577.1 - 1.6e-07 30.9 0.4 0.018 14.3 0.0 3.6 1 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO05577.1 - 2.2e-07 30.2 0.2 0.024 13.6 0.0 4.0 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO05577.1 - 6.1e-07 29.2 0.3 1.1 9.3 0.0 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO05577.1 - 0.00012 21.3 0.2 0.14 11.1 0.3 2.5 1 1 1 2 2 2 2 Coatomer WD associated region Nup160 PF11715.8 ETO05577.1 - 0.00017 20.4 0.3 0.3 9.7 0.0 3.4 2 1 2 4 4 4 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO05577.1 - 0.00087 17.9 0.1 0.045 12.3 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO05577.1 - 0.002 17.5 0.5 10 5.4 0.0 3.6 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO05577.1 - 0.0042 17.2 0.2 39 4.3 0.0 3.7 1 1 3 4 4 4 0 Family of unknown function (DUF5570) CN_hydrolase PF00795.22 ETO05577.1 - 0.015 14.6 0.6 0.26 10.6 0.0 2.6 2 1 1 3 3 3 0 Carbon-nitrogen hydrolase Proteasome_A_N PF10584.9 ETO05577.1 - 0.021 14.5 5.9 5 6.9 0.0 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature MIase PF02426.16 ETO05577.1 - 0.12 12.6 0.1 63 3.8 0.0 3.5 4 0 0 4 4 4 0 Muconolactone delta-isomerase TruB_C PF09142.11 ETO05577.1 - 0.23 11.3 0.0 0.97 9.3 0.0 2.0 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal WD40 PF00400.32 ETO05578.1 - 2.2e-28 97.9 13.1 9.4e-08 32.6 0.1 5.6 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05578.1 - 7.2e-10 39.0 0.8 0.00039 20.7 0.1 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05578.1 - 1.8e-05 23.8 1.3 0.027 13.4 0.1 3.1 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO05578.1 - 0.00039 19.1 0.3 0.052 12.1 0.1 2.3 1 1 2 3 3 3 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO05578.1 - 0.0005 19.5 1.2 0.0072 15.7 0.2 1.9 1 1 2 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO05578.1 - 0.0022 17.9 0.2 2.2 8.3 0.1 3.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO05578.1 - 0.18 11.5 0.3 17 5.2 0.0 2.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature PPR_2 PF13041.6 ETO05579.1 - 3.5e-13 49.5 6.3 1.2e-07 31.8 0.6 3.9 3 1 1 4 4 4 4 PPR repeat family PPR PF01535.20 ETO05579.1 - 9.1e-13 47.5 4.8 0.0011 19.1 0.0 4.5 4 0 0 4 4 4 4 PPR repeat PPR_1 PF12854.7 ETO05579.1 - 8.8e-08 31.7 1.0 0.0023 17.6 0.0 3.5 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 ETO05579.1 - 2e-05 24.6 3.3 0.0016 18.5 0.5 3.3 2 1 2 4 4 4 3 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO05579.1 - 0.0027 17.1 2.1 0.018 14.4 0.2 2.5 1 1 1 3 3 3 2 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO05579.1 - 0.017 15.0 0.8 0.1 12.5 0.1 2.4 1 1 1 2 2 2 0 Mitochondrial ATPase expression DUF3636 PF12331.8 ETO05579.1 - 0.16 11.8 1.8 0.21 11.4 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) PP2C PF00481.21 ETO05580.1 - 1.8e-07 31.1 0.2 2.5e-06 27.3 0.2 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C Gal-bind_lectin PF00337.22 ETO05581.1 - 0.029 13.9 0.4 0.036 13.6 0.4 1.1 1 0 0 1 1 1 0 Galactoside-binding lectin ETRAMP PF09716.10 ETO05583.1 - 0.012 15.6 0.1 0.012 15.6 0.1 2.7 2 1 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) DUF3533 PF12051.8 ETO05588.1 - 3.8 6.3 4.3 4.7 6.0 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) DUF5436 PF17504.2 ETO05589.1 - 0.022 15.1 0.2 0.054 13.8 0.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5436) DUF485 PF04341.12 ETO05589.1 - 0.032 14.2 0.0 0.058 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Saf_2TM PF18303.1 ETO05589.1 - 0.068 12.8 0.0 0.095 12.3 0.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Adeno_E3 PF06040.11 ETO05592.1 - 0.014 15.6 0.8 0.025 14.7 0.8 1.4 1 0 0 1 1 1 0 Adenovirus E3 protein DUF2430 PF10353.9 ETO05592.1 - 0.052 13.9 2.1 0.087 13.2 2.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2430) EVI2A PF05399.11 ETO05592.1 - 0.11 12.0 4.2 0.17 11.5 4.2 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) RGS-like PF09128.11 ETO05594.1 - 0.0079 15.9 0.1 0.016 14.9 0.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signalling-like domain MRP-S27 PF10037.9 ETO05596.1 - 0.0023 16.9 0.6 0.0036 16.2 0.1 1.5 1 1 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 Arnt_C PF18583.1 ETO05596.1 - 0.0069 16.0 0.1 0.0092 15.6 0.1 1.1 1 0 0 1 1 1 1 Aminoarabinose transferase C-terminal domain DUF4446 PF14584.6 ETO05596.1 - 0.0094 15.9 3.0 0.012 15.6 3.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) Cas_DxTHG PF09455.10 ETO05596.1 - 0.014 15.0 0.5 0.015 14.9 0.5 1.0 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family DUF4704 PF15787.5 ETO05597.1 - 1.5e-06 27.7 0.6 0.23 10.7 0.1 3.6 3 0 0 3 3 3 2 Domain of unknown function (DUF4704) Spt20 PF12090.8 ETO05597.1 - 0.00013 21.7 20.8 0.00013 21.7 20.8 2.4 2 0 0 2 2 2 1 Spt20 family TFIIA PF03153.13 ETO05597.1 - 0.00066 19.8 14.1 0.00066 19.8 14.1 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit TERB2 PF15101.6 ETO05597.1 - 0.065 13.3 8.7 0.14 12.2 8.7 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DivIC PF04977.15 ETO05597.1 - 0.094 12.5 13.7 0.22 11.3 13.7 1.6 1 0 0 1 1 1 0 Septum formation initiator MTP18 PF10558.9 ETO05597.1 - 0.17 11.8 1.4 0.44 10.5 1.4 1.6 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) DUF4407 PF14362.6 ETO05597.1 - 0.6 9.4 7.0 1.1 8.5 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ctr PF04145.15 ETO05597.1 - 1.8 9.2 6.0 6.4 7.4 1.3 2.9 3 0 0 3 3 3 0 Ctr copper transporter family CHD5 PF04420.14 ETO05597.1 - 1.8 8.4 11.9 4.9 7.0 11.9 1.7 1 0 0 1 1 1 0 CHD5-like protein FragX_IP PF05994.11 ETO05598.1 - 0.0056 14.8 0.3 0.0076 14.4 0.3 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family Merozoite_SPAM PF07133.11 ETO05599.1 - 0.19 11.7 32.5 0.25 11.3 32.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF4637 PF15470.6 ETO05599.1 - 0.37 10.5 18.1 0.61 9.8 18.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Nop14 PF04147.12 ETO05599.1 - 0.59 8.3 25.2 0.64 8.2 25.2 1.1 1 0 0 1 1 1 0 Nop14-like family Tim54 PF11711.8 ETO05599.1 - 0.62 8.8 10.6 0.64 8.7 10.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 ETO05599.1 - 1.3 7.7 13.2 1.3 7.7 13.2 1.1 1 0 0 1 1 1 0 Presenilin TFIIF_alpha PF05793.12 ETO05599.1 - 1.8 7.0 31.0 2.3 6.7 31.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Raftlin PF15250.6 ETO05599.1 - 1.9 7.1 11.7 2.2 6.9 11.7 1.1 1 0 0 1 1 1 0 Raftlin CPSF100_C PF13299.6 ETO05599.1 - 2 8.6 9.6 3.1 7.9 9.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 ETO05599.1 - 2.7 7.1 8.7 2.8 7.1 8.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Mpp10 PF04006.12 ETO05599.1 - 2.8 6.3 27.8 3.4 6.0 27.8 1.1 1 0 0 1 1 1 0 Mpp10 protein CDC45 PF02724.14 ETO05599.1 - 2.9 6.1 19.9 2.8 6.1 19.9 1.1 1 0 0 1 1 1 0 CDC45-like protein HSP70 PF00012.20 ETO05599.1 - 5.3 5.1 10.2 5.8 5.0 10.2 1.0 1 0 0 1 1 1 0 Hsp70 protein SLC12 PF03522.15 ETO05599.1 - 5.4 5.9 8.2 5.3 6.0 8.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Sec62 PF03839.16 ETO05599.1 - 5.9 6.3 5.5 7.3 6.0 5.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 ETO05599.1 - 6 6.6 16.0 8.3 6.2 16.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 ETO05599.1 - 6.5 5.5 7.5 7.6 5.2 7.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Lin-8 PF03353.15 ETO05599.1 - 7.6 6.0 15.8 8.3 5.9 15.8 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Peptidase_S64 PF08192.11 ETO05599.1 - 7.9 4.8 10.2 7.9 4.8 10.2 1.0 1 0 0 1 1 1 0 Peptidase family S64 DUF4617 PF15395.6 ETO05600.1 - 0.0022 16.4 0.4 0.0022 16.4 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4617) Arm_2 PF04826.13 ETO05601.1 - 0.0021 17.5 0.2 0.13 11.7 0.1 2.1 1 1 1 2 2 2 2 Armadillo-like Di19_C PF14571.6 ETO05604.1 - 0.19 12.3 5.8 0.12 12.9 4.1 1.5 1 1 1 2 2 2 0 Stress-induced protein Di19, C-terminal Connexin PF00029.19 ETO05604.1 - 4.4 7.0 7.1 5.1 6.8 7.1 1.2 1 0 0 1 1 1 0 Connexin DUF4770 PF15994.5 ETO05605.1 - 0.087 13.1 10.5 0.11 12.7 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) OATP PF03137.20 ETO05605.1 - 0.1 10.9 4.5 0.12 10.6 4.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Sec62 PF03839.16 ETO05605.1 - 0.12 11.9 12.2 0.16 11.5 12.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RNA_pol_Rpb1_5 PF04998.17 ETO05605.1 - 0.21 11.0 7.3 0.23 10.9 7.3 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Membralin PF09746.9 ETO05605.1 - 1.3 8.0 8.7 1.6 7.7 8.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein Choline_sulf_C PF12411.8 ETO05606.1 - 0.095 12.5 0.1 0.44 10.4 0.0 2.0 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal DUF2286 PF10051.9 ETO05607.1 - 0.046 13.5 0.1 0.14 11.9 0.0 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2286) RTP1_C1 PF10363.9 ETO05608.1 - 0.0011 19.1 0.9 1 9.6 0.0 2.2 1 1 1 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 LBP_BPI_CETP PF01273.25 ETO05608.1 - 0.039 13.6 0.4 0.51 9.9 0.0 2.1 1 1 1 2 2 2 0 LBP / BPI / CETP family, N-terminal domain Cnd1 PF12717.7 ETO05608.1 - 0.049 13.7 0.3 0.1 12.7 0.3 1.5 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 NLRC4_HD2 PF17776.1 ETO05608.1 - 0.18 12.4 1.5 0.36 11.4 0.6 2.0 2 1 1 3 3 3 0 NLRC4 helical domain HD2 E1-E2_ATPase PF00122.20 ETO05609.1 - 1.5e-44 151.7 1.1 1.5e-44 151.7 1.1 2.0 2 1 0 2 2 2 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETO05609.1 - 2.7e-25 89.1 0.0 5.8e-25 88.0 0.0 1.5 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETO05609.1 - 5.7e-25 88.8 0.2 9.9e-24 84.8 0.1 2.8 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO05609.1 - 5.6e-11 42.4 0.0 1.1e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETO05609.1 - 8.2e-10 38.8 3.1 2.2e-06 27.6 1.3 2.8 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO05609.1 - 6.3e-07 30.0 0.1 4.9e-06 27.1 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETO05609.1 - 0.00029 20.9 0.0 0.006 16.7 0.0 2.7 2 1 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Exostosin PF03016.15 ETO05609.1 - 0.012 14.8 0.1 0.02 14.1 0.1 1.2 1 0 0 1 1 1 0 Exostosin family DUF775 PF05603.12 ETO05611.1 - 0.03 13.8 0.1 0.037 13.6 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF775) CCDC144C PF14915.6 ETO05615.1 - 9.6e-06 24.9 19.6 6.7e-05 22.2 5.2 2.7 2 0 0 2 2 2 2 CCDC144C protein coiled-coil region DUF2207 PF09972.9 ETO05615.1 - 0.0013 17.6 1.8 0.0036 16.1 0.3 2.3 2 0 0 2 2 2 1 Predicted membrane protein (DUF2207) TMEM154 PF15102.6 ETO05615.1 - 0.0016 18.4 0.4 0.0016 18.4 0.4 3.4 4 0 0 4 4 4 1 TMEM154 protein family Shisa PF13908.6 ETO05615.1 - 0.0028 17.9 0.1 0.0028 17.9 0.1 3.0 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator DUF5305 PF17231.2 ETO05615.1 - 0.0035 16.8 2.5 0.027 13.9 0.2 3.1 3 0 0 3 3 3 1 Family of unknown function (DUF5305) DUF4795 PF16043.5 ETO05615.1 - 0.014 15.0 20.7 0.32 10.6 5.3 3.9 2 2 1 3 3 3 0 Domain of unknown function (DUF4795) Orf78 PF06024.12 ETO05615.1 - 0.014 15.7 0.8 0.014 15.7 0.8 3.8 4 0 0 4 4 4 0 Orf78 (ac78) ECSCR PF15820.5 ETO05615.1 - 0.023 14.5 1.3 0.023 14.5 1.3 2.2 2 0 0 2 2 1 0 Endothelial cell-specific chemotaxis regulator ASFV_J13L PF05568.11 ETO05615.1 - 0.026 14.3 0.8 0.063 13.0 0.8 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein YqbF PF14553.6 ETO05615.1 - 0.059 13.2 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 YqbF, hypothetical protein domain Wzy_C PF04932.15 ETO05615.1 - 0.061 12.9 0.4 0.17 11.5 0.0 1.9 2 0 0 2 2 2 0 O-Antigen ligase DUF3377 PF11857.8 ETO05615.1 - 0.27 11.2 4.1 0.16 11.9 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF4315 PF14193.6 ETO05615.1 - 1.8 8.6 8.3 1.4 9.0 0.1 3.5 2 1 1 3 3 2 0 Domain of unknown function (DUF4315) DUF4164 PF13747.6 ETO05615.1 - 2.5 8.4 9.0 1.6 9.1 2.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) EphA2_TM PF14575.6 ETO05615.1 - 4.7 8.2 13.1 3.2 8.7 6.3 3.4 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMF_TATA_bd PF12325.8 ETO05615.1 - 4.8 7.4 16.1 0.033 14.4 2.1 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Pox_EPC_I2-L1 PF12575.8 ETO05615.1 - 6.6 7.0 8.7 0.72 10.1 1.2 3.1 3 0 0 3 3 2 0 Poxvirus entry protein complex L1 and I2 Secretin_N_2 PF07655.13 ETO05615.1 - 6.7 7.3 19.1 0.42 11.2 12.5 2.4 3 0 0 3 3 1 0 Secretin N-terminal domain Presenilin PF01080.17 ETO05615.1 - 8.5 5.0 11.4 1.9 7.2 0.5 2.5 2 0 0 2 2 2 0 Presenilin SET PF00856.28 ETO05616.1 - 3.6e-07 30.7 0.5 7.6e-07 29.7 0.5 1.5 1 0 0 1 1 1 1 SET domain ubiquitin PF00240.23 ETO05617.1 - 7.7e-30 102.5 0.5 1.6e-29 101.4 0.5 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO05617.1 - 1.1e-13 50.8 0.3 1.9e-13 50.0 0.3 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO05617.1 - 0.00012 22.5 0.1 0.00041 20.7 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO05617.1 - 0.0036 17.2 0.0 0.0089 15.9 0.0 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO05617.1 - 0.022 15.1 1.2 0.035 14.4 0.2 1.9 1 1 2 3 3 3 0 Ubiquitin-like domain DUF2407 PF10302.9 ETO05617.1 - 0.04 14.5 0.0 0.1 13.1 0.0 1.6 1 0 0 1 1 1 0 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO05617.1 - 0.065 13.4 1.6 0.12 12.5 0.0 2.1 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Pkinase PF00069.25 ETO05620.1 - 6e-06 25.8 0.0 8.9e-06 25.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05620.1 - 0.066 12.5 0.0 0.097 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase PIN_3 PF13470.6 ETO05621.1 - 0.056 14.2 0.1 0.56 11.0 0.0 2.0 2 0 0 2 2 2 0 PIN domain TRM PF02005.16 ETO05622.1 - 0.0043 16.3 0.4 0.0069 15.6 0.4 1.3 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase CbiK PF06180.11 ETO05622.1 - 0.012 14.9 0.1 0.036 13.4 0.1 1.7 1 1 0 1 1 1 0 Cobalt chelatase (CbiK) GFRP PF06399.13 ETO05622.1 - 0.099 12.5 0.2 2 8.3 0.0 2.9 3 1 1 4 4 4 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) IFT81_CH PF18383.1 ETO05622.1 - 0.22 11.8 5.2 0.47 10.7 0.6 2.6 2 1 1 3 3 3 0 Intraflagellar transport 81 calponin homology domain WD40 PF00400.32 ETO05623.1 - 9.4e-09 35.8 1.8 1.9e-06 28.5 0.2 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat zf-RanBP PF00641.18 ETO05625.1 - 2.2e-05 23.7 1.7 5.7e-05 22.4 1.7 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-UBR PF02207.20 ETO05625.1 - 0.0067 16.6 0.5 0.015 15.4 0.5 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Peptidase_C34 PF05413.11 ETO05625.1 - 0.13 12.6 0.1 0.23 11.7 0.1 1.4 1 0 0 1 1 1 0 Putative closterovirus papain-like endopeptidase NinG PF05766.12 ETO05625.1 - 0.77 9.7 7.0 1.2 9.1 7.0 1.3 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein Pkinase PF00069.25 ETO05626.1 - 1.1e-13 51.1 0.3 1.1e-13 51.1 0.3 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05626.1 - 3.9e-07 29.6 0.5 3.9e-07 29.6 0.5 2.3 1 1 1 2 2 2 1 Protein tyrosine kinase SNARE PF05739.19 ETO05626.1 - 0.18 11.8 2.2 4.4 7.4 0.1 3.0 2 0 0 2 2 2 0 SNARE domain Pkinase PF00069.25 ETO05627.1 - 4e-37 128.0 0.0 5.1e-37 127.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05627.1 - 4.2e-23 81.9 0.0 5.6e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO05627.1 - 1.9e-07 30.7 0.0 2.4e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO05627.1 - 0.016 14.0 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 ETO05627.1 - 0.071 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family HTH_52 PF18576.1 ETO05627.1 - 0.12 12.6 0.5 1.4 9.2 0.0 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain Pho86 PF11124.8 ETO05628.1 - 0.13 11.7 0.3 0.16 11.4 0.3 1.1 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 Mago_nashi PF02792.14 ETO05629.1 - 1.1e-65 220.0 0.7 1.4e-65 219.8 0.7 1.0 1 0 0 1 1 1 1 Mago nashi protein Fucose_iso_C PF02952.17 ETO05630.1 - 0.0065 16.2 0.1 0.0098 15.6 0.1 1.3 1 1 0 1 1 1 1 L-fucose isomerase, C-terminal domain Sharpin_PH PF16764.5 ETO05630.1 - 0.062 13.1 0.1 0.082 12.7 0.1 1.3 1 0 0 1 1 1 0 Sharpin PH domain Bcr-Abl_Oligo PF09036.10 ETO05630.1 - 0.097 12.7 0.2 0.097 12.7 0.2 2.1 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain THOC7 PF05615.13 ETO05630.1 - 6.8 7.0 16.4 15 5.9 15.3 1.8 1 1 1 2 2 2 0 Tho complex subunit 7 DUF3449 PF11931.8 ETO05631.1 - 1e-05 25.4 5.4 1.5e-05 24.9 5.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3449) DUF1644 PF07800.12 ETO05631.1 - 0.0031 17.6 1.4 0.005 16.9 1.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1644) zf-C2H2_2 PF12756.7 ETO05631.1 - 0.0056 17.0 0.5 0.011 16.0 0.2 1.7 1 1 0 1 1 1 1 C2H2 type zinc-finger (2 copies) Vps4_C PF09336.10 ETO05631.1 - 0.2 11.7 1.3 0.49 10.4 0.0 2.3 3 0 0 3 3 3 0 Vps4 C terminal oligomerisation domain PA PF02225.22 ETO05634.1 - 0.00087 19.3 0.0 0.00097 19.1 0.0 1.2 1 0 0 1 1 1 1 PA domain NRIP1_repr_2 PF15688.5 ETO05634.1 - 0.057 13.3 0.0 0.076 12.9 0.0 1.1 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 2 adh_short PF00106.25 ETO05635.1 - 9.1e-33 113.4 0.0 1.3e-32 112.9 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO05635.1 - 6e-23 81.6 0.0 8.4e-23 81.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO05635.1 - 9.1e-11 42.0 0.1 1.7e-10 41.1 0.1 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETO05635.1 - 0.00079 19.4 0.0 0.032 14.1 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding DUF1776 PF08643.10 ETO05635.1 - 0.01 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) THF_DHG_CYH_C PF02882.19 ETO05635.1 - 0.15 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain U-box PF04564.15 ETO05636.1 - 3.1e-21 75.3 0.0 9.5e-21 73.8 0.0 1.8 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ETO05636.1 - 1.1e-05 25.1 0.0 3.2e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-RING_UBOX PF13445.6 ETO05636.1 - 0.0045 17.0 0.0 0.0099 15.9 0.0 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-NOSIP PF15906.5 ETO05636.1 - 0.01 16.0 0.0 0.023 14.8 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Rtf2 PF04641.12 ETO05636.1 - 0.11 11.8 0.1 0.35 10.2 0.0 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger POR_N PF01855.19 ETO05636.1 - 0.13 11.9 0.9 0.23 11.2 0.9 1.3 1 0 0 1 1 1 0 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg MSP1_C PF07462.11 ETO05636.1 - 0.31 9.7 3.8 0.38 9.4 2.3 1.7 2 0 0 2 2 2 0 Merozoite surface protein 1 (MSP1) C-terminus Gly-zipper_Omp PF13488.6 ETO05636.1 - 1.9 8.5 23.2 8.6 6.4 23.2 1.9 1 1 0 1 1 1 0 Glycine zipper Rick_17kDa_Anti PF05433.15 ETO05636.1 - 5.5 6.9 22.1 10 6.1 22.1 1.5 1 0 0 1 1 1 0 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 ETO05636.1 - 6.9 6.5 22.5 29 4.5 22.5 1.9 1 1 0 1 1 1 0 YMGG-like Gly-zipper DUF3262 PF11660.8 ETO05637.1 - 0.0062 16.9 0.6 0.01 16.2 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3262) Tad PF13400.6 ETO05637.1 - 0.044 14.1 0.5 0.061 13.6 0.5 1.2 1 0 0 1 1 1 0 Putative Flp pilus-assembly TadE/G-like DUF4366 PF14283.6 ETO05637.1 - 0.093 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) KNTase_C PF07827.11 ETO05638.1 - 0.088 12.6 0.1 0.29 10.9 0.1 1.9 1 0 0 1 1 1 0 KNTase C-terminal domain DUF3236 PF11576.8 ETO05638.1 - 0.13 11.9 1.4 0.19 11.4 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3236) NACHT PF05729.12 ETO05639.1 - 0.17 11.8 2.3 1.1 9.1 0.1 2.7 3 0 0 3 3 3 0 NACHT domain KaiA PF07688.12 ETO05642.1 - 0.097 12.8 1.5 0.18 12.0 1.5 1.4 1 0 0 1 1 1 0 KaiA C-terminal domain CALM_bind PF16025.5 ETO05642.1 - 0.38 11.3 6.5 0.15 12.6 3.9 1.7 2 0 0 2 2 2 0 Calcium-dependent calmodulin binding FTO_CTD PF12934.7 ETO05645.1 - 0.12 12.1 0.4 0.38 10.5 0.1 1.8 1 1 1 2 2 2 0 FTO C-terminal domain WD40 PF00400.32 ETO05646.1 - 4.9e-17 62.0 20.1 1.2e-05 25.9 0.1 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO05646.1 - 5.2e-10 38.6 0.9 0.00049 18.9 0.1 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05646.1 - 7.3e-05 23.0 0.1 0.72 10.2 0.0 2.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO05646.1 - 0.0025 17.8 0.0 0.13 12.3 0.0 2.3 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ETO05646.1 - 0.0054 16.1 1.0 0.9 8.8 0.3 2.8 1 1 2 3 3 3 1 WD40-like domain HARP PF07443.13 ETO05646.1 - 0.26 10.9 0.9 0.74 9.5 0.0 2.2 3 0 0 3 3 3 0 HepA-related protein (HARP) Kelch_2 PF07646.15 ETO05646.1 - 0.69 10.0 4.6 1 9.4 0.1 3.0 3 1 0 3 3 3 0 Kelch motif zf-CCCH_7 PF18586.1 ETO05647.1 - 0.068 13.5 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Rep_fac-A_3 PF08661.11 ETO05647.1 - 0.081 13.3 1.0 10 6.5 0.2 2.2 1 1 1 2 2 2 0 Replication factor A protein 3 NPR3 PF03666.13 ETO05648.1 - 0.12 11.1 9.8 0.15 10.9 9.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Raftlin PF15250.6 ETO05648.1 - 0.29 9.8 3.3 0.35 9.6 3.3 1.1 1 0 0 1 1 1 0 Raftlin LCE6A PF15858.5 ETO05648.1 - 1.3 9.8 6.7 0.15 12.8 1.9 1.9 1 1 1 2 2 2 0 Late cornified envelope protein 6A family RP-C_C PF11800.8 ETO05648.1 - 1.6 8.8 4.9 2.3 8.3 4.9 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 ETO05648.1 - 2.1 7.5 10.2 2.7 7.1 10.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO05648.1 - 2.6 6.7 11.9 3.4 6.3 11.9 1.1 1 0 0 1 1 1 0 Presenilin HD-ZIP_N PF04618.12 ETO05649.1 - 0.0025 18.3 4.6 0.0035 17.8 4.6 1.3 1 0 0 1 1 1 1 HD-ZIP protein N terminus TFIIA PF03153.13 ETO05649.1 - 0.011 15.8 30.2 0.011 15.7 30.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CSG2 PF16965.5 ETO05649.1 - 0.013 14.5 3.4 0.014 14.4 3.4 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 ETO05649.1 - 0.015 14.1 8.6 0.015 14.1 8.6 1.0 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 ETO05649.1 - 0.021 14.3 8.7 0.022 14.3 8.7 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Pex14_N PF04695.13 ETO05649.1 - 0.022 15.4 18.6 0.027 15.1 18.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4407 PF14362.6 ETO05649.1 - 0.029 13.7 9.3 0.033 13.6 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) eIF-3_zeta PF05091.12 ETO05649.1 - 0.034 13.1 14.2 0.038 13.0 14.2 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF4175 PF13779.6 ETO05649.1 - 0.044 11.7 25.1 0.04 11.8 25.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) PAF-AH_p_II PF03403.13 ETO05649.1 - 0.055 12.0 6.3 0.064 11.8 6.3 1.0 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II Ureide_permease PF07168.11 ETO05649.1 - 0.11 11.2 1.3 0.13 11.0 1.3 1.1 1 0 0 1 1 1 0 Ureide permease PAT1 PF09770.9 ETO05649.1 - 0.12 10.6 20.6 0.13 10.6 20.6 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Vma12 PF11712.8 ETO05649.1 - 0.26 11.4 7.9 0.29 11.2 7.9 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Sin_N PF04801.13 ETO05649.1 - 0.29 10.3 21.1 0.34 10.1 21.1 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region DUF2072 PF09845.9 ETO05649.1 - 0.36 11.1 6.9 0.5 10.6 6.9 1.1 1 0 0 1 1 1 0 Zn-ribbon containing protein PepSY_TM PF03929.16 ETO05649.1 - 0.37 10.4 2.9 0.4 10.3 2.9 1.1 1 0 0 1 1 1 0 PepSY-associated TM region STAC2_u1 PF16664.5 ETO05649.1 - 0.38 11.2 8.3 0.52 10.8 8.3 1.2 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 BORG_CEP PF14957.6 ETO05649.1 - 0.39 11.9 6.6 0.47 11.6 6.6 1.3 1 0 0 1 1 1 0 Cdc42 effector Exonuc_VII_L PF02601.15 ETO05649.1 - 0.41 10.2 11.2 0.44 10.1 11.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit OATP PF03137.20 ETO05649.1 - 0.69 8.1 4.2 0.76 8.0 4.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CPSF100_C PF13299.6 ETO05649.1 - 0.71 10.0 6.8 0.88 9.7 6.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2126 PF09899.9 ETO05649.1 - 0.74 7.8 6.0 0.84 7.6 6.0 1.1 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) EMC3_TMCO1 PF01956.16 ETO05649.1 - 0.82 9.4 14.6 1.2 8.8 14.6 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like CobT PF06213.12 ETO05649.1 - 0.86 8.9 16.1 1.1 8.6 16.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BBL5 PF07289.11 ETO05649.1 - 0.89 8.5 9.7 1.1 8.3 9.7 1.1 1 0 0 1 1 1 0 Bardet-Biedl syndrome 5 protein AIF_C PF14721.6 ETO05649.1 - 0.97 9.8 8.6 1.4 9.3 8.6 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term GREB1 PF15782.5 ETO05649.1 - 1.1 6.3 11.1 1.2 6.2 11.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CLN3 PF02487.17 ETO05649.1 - 1.6 7.7 10.2 2 7.4 10.2 1.1 1 0 0 1 1 1 0 CLN3 protein UPF0560 PF10577.9 ETO05649.1 - 2.1 6.7 19.3 2.4 6.6 19.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PBP1_TM PF14812.6 ETO05649.1 - 3.2 8.2 6.6 4.5 7.7 6.6 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Membralin PF09746.9 ETO05649.1 - 3.5 6.6 10.9 4.3 6.3 10.9 1.0 1 0 0 1 1 1 0 Tumour-associated protein DUF2828 PF11443.8 ETO05649.1 - 3.7 5.5 12.3 4.2 5.3 12.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF853 PF05872.12 ETO05649.1 - 5.7 5.4 10.6 6.9 5.1 10.6 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Connexin PF00029.19 ETO05649.1 - 6.1 6.5 11.6 7.5 6.2 11.6 1.1 1 0 0 1 1 1 0 Connexin ABC2_membrane_2 PF12679.7 ETO05649.1 - 6.6 5.9 5.5 8 5.6 5.5 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein EOS1 PF12326.8 ETO05649.1 - 6.7 6.6 8.1 8.4 6.3 8.1 1.2 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 ETO05649.1 - 7.6 6.5 10.6 9.6 6.2 10.6 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Band_3_cyto PF07565.13 ETO05649.1 - 7.7 6.2 13.7 9.6 5.9 13.7 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain EIF4E-T PF10477.9 ETO05649.1 - 8.7 5.0 22.4 9.6 4.9 22.4 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E MIEAP PF16026.5 ETO05651.1 - 1.9e-07 31.5 6.5 1.9e-07 31.5 6.5 4.7 2 2 1 4 4 3 1 Mitochondria-eating protein WEMBL PF05701.11 ETO05651.1 - 9.6e-05 21.3 26.3 9.6e-05 21.3 26.3 3.2 3 1 1 4 4 4 2 Weak chloroplast movement under blue light DUF1043 PF06295.12 ETO05651.1 - 0.00017 21.6 1.3 0.00017 21.6 1.3 5.0 3 1 1 4 4 4 1 Protein of unknown function (DUF1043) MscS_porin PF12795.7 ETO05651.1 - 0.002 17.7 5.2 0.002 17.7 5.2 4.1 4 0 0 4 4 4 2 Mechanosensitive ion channel porin domain Spc7 PF08317.11 ETO05651.1 - 0.0042 16.0 8.7 0.0042 16.0 8.7 5.1 4 1 1 5 5 5 3 Spc7 kinetochore protein DPM3 PF08285.11 ETO05651.1 - 0.0098 16.1 0.1 0.12 12.6 0.1 3.0 1 0 0 1 1 1 1 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF3450 PF11932.8 ETO05651.1 - 0.015 14.6 0.7 0.015 14.6 0.7 4.1 4 0 0 4 4 4 0 Protein of unknown function (DUF3450) Docking PF08990.11 ETO05651.1 - 0.06 13.0 0.3 14 5.4 0.0 3.0 2 0 0 2 2 2 0 Erythronolide synthase docking CENP-F_leu_zip PF10473.9 ETO05651.1 - 0.28 11.2 56.2 0.24 11.4 8.5 5.2 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HrpB7 PF09486.10 ETO05651.1 - 0.56 10.6 22.1 1.8 9.0 0.6 3.9 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB7) DegS PF05384.11 ETO05651.1 - 1.5 8.3 35.5 2.8 7.4 3.4 4.7 4 1 0 4 4 4 0 Sensor protein DegS VIT1 PF01988.19 ETO05651.1 - 2.2 8.1 12.8 0.42 10.5 0.1 3.5 2 1 1 3 3 3 0 VIT family Tropomyosin PF00261.20 ETO05651.1 - 2.4 7.5 49.9 0.062 12.7 9.4 3.8 3 0 0 3 3 3 0 Tropomyosin Fez1 PF06818.15 ETO05651.1 - 3.1 8.2 60.8 0.084 13.3 13.3 4.9 3 1 0 3 3 2 0 Fez1 Ntox28 PF15605.6 ETO05651.1 - 5 7.4 24.3 0.34 11.2 1.6 4.3 3 1 0 3 3 3 0 Bacterial toxin 28 DUF745 PF05335.13 ETO05651.1 - 8.2 6.1 41.5 0.18 11.5 7.9 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF745) US6 PF17616.2 ETO05652.1 - 0.11 12.4 0.2 0.18 11.7 0.2 1.4 1 1 0 1 1 1 0 Viral unique short region 6 YMF19 PF02326.15 ETO05652.1 - 1.7 9.5 5.6 0.82 10.5 3.1 1.8 2 0 0 2 2 2 0 Plant ATP synthase F0 14-3-3 PF00244.20 ETO05653.1 - 1.2e-88 296.4 2.7 1.3e-88 296.2 2.7 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 ETO05653.1 - 0.00031 21.0 0.3 0.0015 18.8 0.2 2.3 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05653.1 - 0.01 16.0 4.1 0.16 12.3 0.5 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat TetR_C_37 PF18665.1 ETO05653.1 - 0.73 10.5 4.8 0.6 10.7 3.0 1.7 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_1 PF00515.28 ETO05653.1 - 1.5 8.7 4.4 1.3 9.0 0.4 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05653.1 - 2 8.7 8.4 2.9 8.2 2.4 3.3 3 2 0 3 3 3 0 Tetratricopeptide repeat NACHT PF05729.12 ETO05654.1 - 3e-07 30.5 0.0 7.7e-07 29.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO05654.1 - 0.00067 19.9 0.0 0.0022 18.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO05654.1 - 0.0019 18.2 0.1 0.38 10.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO05654.1 - 0.016 15.6 0.0 0.056 13.9 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ETO05654.1 - 0.017 14.9 0.0 0.6 9.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ETO05654.1 - 0.034 14.2 0.2 0.56 10.2 0.0 2.5 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ETO05654.1 - 0.13 12.8 2.7 0.39 11.3 0.0 3.1 2 1 1 3 3 3 0 AAA domain Snf7 PF03357.21 ETO05655.1 - 6e-10 39.0 21.6 6e-10 39.0 21.6 1.3 1 1 0 1 1 1 1 Snf7 Ist1 PF03398.14 ETO05655.1 - 0.00032 20.7 7.6 0.00087 19.3 7.6 1.7 1 1 0 1 1 1 1 Regulator of Vps4 activity in the MVB pathway Metal_resist PF13801.6 ETO05655.1 - 0.0031 17.7 8.6 0.026 14.7 0.9 2.3 1 1 1 2 2 2 2 Heavy-metal resistance PG_binding_4 PF12229.8 ETO05655.1 - 0.043 14.1 3.7 0.61 10.4 0.3 2.5 2 1 0 2 2 2 0 Putative peptidoglycan binding domain DUF3410 PF11890.8 ETO05655.1 - 0.057 13.2 1.3 0.55 10.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3410) SurA_N PF09312.11 ETO05655.1 - 0.085 12.9 4.3 0.41 10.7 2.7 2.5 1 1 1 2 2 2 0 SurA N-terminal domain Matrilin_ccoil PF10393.9 ETO05655.1 - 1 9.3 7.5 4.5 7.2 0.1 3.5 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin DUF1664 PF07889.12 ETO05655.1 - 6 6.9 13.2 0.26 11.4 5.4 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) NodA PF02474.15 ETO05656.1 - 0.094 12.4 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Nodulation protein A (NodA) PhoQ_Sensor PF08918.10 ETO05656.1 - 0.16 11.8 1.2 0.19 11.5 1.2 1.1 1 0 0 1 1 1 0 PhoQ Sensor ANAPC4_WD40 PF12894.7 ETO05657.1 - 0.00028 21.1 0.1 2 8.8 0.0 3.8 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Glyco_hydro_18 PF00704.28 ETO05658.1 - 2.7e-13 50.3 0.2 3.3e-13 50.1 0.2 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 HU-CCDC81_euk_1 PF14908.6 ETO05658.1 - 0.00065 19.8 0.0 0.0015 18.7 0.0 1.6 1 1 0 1 1 1 1 CCDC81 eukaryotic HU domain 1 RRN3 PF05327.11 ETO05659.1 - 0.24 9.9 10.1 0.38 9.3 10.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 zf-TRAF PF02176.18 ETO05659.1 - 0.93 10.2 15.1 0.6 10.8 4.8 3.3 2 1 1 3 3 3 0 TRAF-type zinc finger Macoilin PF09726.9 ETO05659.1 - 3.5 6.1 14.2 5.1 5.5 14.2 1.1 1 0 0 1 1 1 0 Macoilin family zf-TRAF_2 PF15965.5 ETO05659.1 - 7.6 7.1 13.0 1.7 9.1 0.8 2.8 1 1 2 3 3 3 0 TRAF-like zinc-finger zf-TRAF PF02176.18 ETO05660.1 - 1.6e-11 44.7 7.7 2.8e-11 43.9 7.7 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger DUF4116 PF13475.6 ETO05660.1 - 0.063 13.0 0.1 9.3 6.1 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4116) zf-TRAF_2 PF15965.5 ETO05660.1 - 0.14 12.7 6.4 0.68 10.4 6.4 2.1 1 1 0 1 1 1 0 TRAF-like zinc-finger Sina PF03145.16 ETO05660.1 - 0.91 9.4 10.7 1.8 8.4 10.8 1.6 1 1 0 1 1 1 0 Seven in absentia protein family Phage_Gp23 PF10669.9 ETO05661.1 - 0.0015 18.9 2.1 0.0025 18.1 2.1 1.5 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) FHIPEP PF00771.20 ETO05661.1 - 0.012 14.1 0.2 0.018 13.5 0.2 1.2 1 0 0 1 1 1 0 FHIPEP family DivIC PF04977.15 ETO05661.1 - 0.013 15.2 0.6 0.027 14.2 0.6 1.5 1 0 0 1 1 1 0 Septum formation initiator FAM176 PF14851.6 ETO05661.1 - 0.028 14.1 0.2 0.048 13.3 0.2 1.4 1 0 0 1 1 1 0 FAM176 family BIRC6 PF12356.8 ETO05661.1 - 0.039 13.4 0.1 0.066 12.6 0.1 1.3 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 DUF4834 PF16118.5 ETO05661.1 - 0.042 14.8 0.3 0.042 14.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 ETO05661.1 - 0.5 11.0 3.3 1.5 9.5 3.3 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Nucleoside_tran PF01733.18 ETO05661.1 - 2.1 7.6 14.1 0.054 12.9 4.1 2.3 2 1 0 2 2 2 0 Nucleoside transporter DUF2140 PF09911.9 ETO05661.1 - 2.3 7.7 8.8 0.038 13.5 1.9 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) WD40 PF00400.32 ETO05662.1 - 2.4e-34 116.8 24.7 8.1e-07 29.7 0.5 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05662.1 - 8.9e-13 48.4 0.3 0.014 15.7 0.0 5.3 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05662.1 - 8.4e-07 28.0 6.5 0.042 12.5 0.3 4.1 1 1 3 4 4 4 3 Nucleoporin Nup120/160 DUF1481 PF07356.12 ETO05662.1 - 0.28 10.9 1.5 21 4.8 0.0 3.4 3 1 0 4 4 4 0 Protein of unknown function (DUF1481) TMCO5 PF14992.6 ETO05663.1 - 0.0042 16.7 1.8 0.0068 16.0 1.8 1.4 1 1 0 1 1 1 1 TMCO5 family ELM2 PF01448.24 ETO05663.1 - 0.0097 16.6 0.0 0.03 15.1 0.0 1.8 2 0 0 2 2 2 1 ELM2 domain DUF4710 PF15828.5 ETO05663.1 - 0.094 12.8 0.1 0.094 12.8 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) RRP7 PF12923.7 ETO05663.1 - 0.095 12.8 2.2 0.66 10.1 0.2 2.3 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain DUF3902 PF13042.6 ETO05663.1 - 0.23 11.0 3.0 0.32 10.6 3.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) SPRY PF00622.28 ETO05664.1 - 5.6e-11 42.6 0.6 2e-10 40.8 0.6 2.0 1 1 0 1 1 1 1 SPRY domain zf-RanBP PF00641.18 ETO05664.1 - 1.4e-06 27.5 4.1 2.4e-06 26.7 4.1 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Atrophin-1 PF03154.15 ETO05664.1 - 0.12 10.6 0.4 0.21 9.8 0.4 1.2 1 0 0 1 1 1 0 Atrophin-1 family FAM76 PF16046.5 ETO05666.1 - 0.34 10.2 6.8 0.49 9.7 6.8 1.2 1 0 0 1 1 1 0 FAM76 protein TFIIA PF03153.13 ETO05666.1 - 4.5 7.2 24.9 5.7 6.8 24.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 ETO05666.1 - 5.8 6.4 15.4 7.8 6.0 15.2 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit CorA PF01544.18 ETO05666.1 - 6 6.1 10.6 2.9 7.1 8.7 1.4 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein CBM_25 PF03423.13 ETO05667.1 - 0.24 11.7 3.8 0.59 10.4 3.8 1.6 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) DivIC PF04977.15 ETO05667.1 - 2.5 7.9 5.8 3.1 7.6 0.1 3.3 3 1 0 3 3 3 0 Septum formation initiator Gemin6 PF06372.12 ETO05668.1 - 9.9e-10 38.2 0.1 6.8e-08 32.2 0.1 2.4 1 1 0 1 1 1 1 Gemin6 protein AD PF09793.9 ETO05668.1 - 0.014 15.5 2.0 0.051 13.7 2.0 1.9 1 1 0 1 1 1 0 Anticodon-binding domain DUF723 PF05265.13 ETO05670.1 - 0.3 11.0 2.5 0.36 10.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF723) zf-C3HC4_4 PF15227.6 ETO05670.1 - 1.1 9.4 6.3 0.3 11.3 1.1 2.7 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING WD40 PF00400.32 ETO05671.1 - 4.8e-33 112.7 20.3 5.4e-07 30.2 0.6 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO05671.1 - 1e-10 40.9 6.6 0.0084 14.8 0.2 4.8 1 1 4 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05671.1 - 1.2e-09 38.4 1.5 0.76 10.1 0.1 5.1 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain DSL PF01414.19 ETO05671.1 - 0.08 13.2 3.2 0.33 11.3 0.7 2.8 2 0 0 2 2 2 0 Delta serrate ligand HrpF PF06266.12 ETO05672.1 - 0.075 13.3 0.4 0.29 11.4 0.1 2.1 2 0 0 2 2 2 0 HrpF protein WD40 PF00400.32 ETO05675.1 - 1.3e-15 57.5 0.9 1.6e-07 31.9 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05675.1 - 9.1e-07 29.1 0.2 0.013 15.8 0.0 2.9 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.6 ETO05677.1 - 8.1e-06 25.8 0.1 8.1e-06 25.8 0.1 3.3 4 1 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO05677.1 - 0.00069 19.8 1.1 0.02 15.2 0.2 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO05677.1 - 0.00083 18.9 3.3 0.0032 17.0 0.3 3.2 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO05677.1 - 0.016 15.2 1.5 0.016 15.2 1.5 1.8 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO05677.1 - 0.02 15.1 0.1 0.15 12.4 0.0 2.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO05677.1 - 0.081 12.9 0.2 0.081 12.9 0.2 2.7 4 0 0 4 4 4 0 Kelch motif HpcH_HpaI PF03328.14 ETO05678.1 - 1.3e-18 66.9 0.0 3.7e-18 65.5 0.0 1.6 2 0 0 2 2 2 1 HpcH/HpaI aldolase/citrate lyase family Dynein_IC2 PF11540.8 ETO05678.1 - 3.8 7.5 7.5 0.22 11.5 0.5 2.3 2 0 0 2 2 2 0 Cytoplasmic dynein 1 intermediate chain 2 WD40 PF00400.32 ETO05679.1 - 2.2e-15 56.8 2.5 1.8e-05 25.4 0.0 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05679.1 - 1.3e-07 31.9 0.1 0.03 14.6 0.0 3.5 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05679.1 - 0.0088 14.7 0.2 1.2 7.7 0.0 2.4 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DDE_3 PF13358.6 ETO05680.1 - 0.00011 22.0 1.1 0.00016 21.4 1.1 1.4 1 0 0 1 1 1 1 DDE superfamily endonuclease WD40 PF00400.32 ETO05681.1 - 0.0098 16.7 0.6 0.69 10.9 0.1 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 ETO05682.1 - 1.9e-49 164.6 16.6 8.3e-09 35.9 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05682.1 - 1.2e-22 80.0 0.4 6.7e-05 23.1 0.0 5.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05682.1 - 1.9e-17 63.6 0.3 1.2e-07 31.4 0.1 3.3 1 1 2 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO05682.1 - 2.3e-09 37.4 0.1 0.0021 18.0 0.0 3.3 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO05682.1 - 9.6e-09 34.6 2.7 0.44 9.5 0.1 5.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05682.1 - 1.1e-07 30.9 5.5 0.1 11.2 0.1 5.1 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO05682.1 - 2.6e-06 26.2 0.1 0.15 10.6 0.0 3.5 1 1 4 5 5 5 4 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO05682.1 - 0.00018 20.9 0.9 0.23 10.8 0.0 3.6 2 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO05682.1 - 0.0002 21.2 5.6 1.9 8.5 0.0 4.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO05682.1 - 0.0076 16.3 0.1 5.4 7.2 0.0 3.9 4 0 0 4 4 4 1 Family of unknown function (DUF5474) DUF5570 PF17731.1 ETO05682.1 - 0.03 14.4 0.3 3 8.0 0.0 3.4 1 1 1 3 3 3 0 Family of unknown function (DUF5570) DUF5122 PF17164.4 ETO05682.1 - 0.061 13.6 0.2 10 6.5 0.1 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller Kelch_1 PF01344.25 ETO05683.1 - 0.0044 16.6 0.0 0.011 15.4 0.0 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO05683.1 - 0.0059 16.6 0.1 0.064 13.3 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO05683.1 - 0.0089 16.0 0.0 0.16 12.0 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Monellin PF09200.10 ETO05683.1 - 0.016 15.1 0.1 0.041 13.7 0.1 1.8 1 0 0 1 1 1 0 Monellin Zona_pellucida PF00100.23 ETO05683.1 - 0.14 12.0 0.0 0.69 9.7 0.0 1.9 2 0 0 2 2 2 0 Zona pellucida-like domain Mlp PF03304.13 ETO05684.1 - 0.0087 16.3 4.6 0.01 16.1 4.6 1.1 1 0 0 1 1 1 1 Mlp lipoprotein family Myotub-related PF06602.14 ETO05685.1 - 2.2e-100 336.0 8.6 8.9e-67 225.5 4.3 2.7 2 0 0 2 2 2 2 Myotubularin-like phosphatase domain FYVE PF01363.21 ETO05685.1 - 3.3e-13 49.5 10.8 1e-12 48.0 10.8 1.8 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ETO05685.1 - 3.8e-05 23.9 5.2 0.00014 22.1 5.2 2.0 1 0 0 1 1 1 1 FYVE-type zinc finger Atrophin-1 PF03154.15 ETO05685.1 - 4.6 5.4 9.0 8.6 4.5 9.0 1.3 1 0 0 1 1 1 0 Atrophin-1 family Pkinase PF00069.25 ETO05691.1 - 2.1e-40 138.8 0.0 3.4e-40 138.1 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05691.1 - 5.2e-12 45.6 0.3 1.1e-10 41.2 0.3 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO05691.1 - 1.1e-09 37.6 0.0 1.4e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO05691.1 - 0.00012 21.5 0.1 0.0005 19.5 0.1 1.9 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO05691.1 - 0.00027 20.4 0.1 0.0019 17.6 0.0 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO05691.1 - 0.0025 17.8 0.0 0.0053 16.7 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Hydantoinase_A PF01968.18 ETO05692.1 - 0.15 11.3 0.0 0.26 10.5 0.0 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase BUD22 PF09073.10 ETO05693.1 - 0.045 13.1 17.8 0.069 12.5 17.8 1.3 1 0 0 1 1 1 0 BUD22 Ribosom_S30AE_C PF16321.5 ETO05693.1 - 0.073 12.8 0.3 0.15 11.8 0.3 1.6 1 0 0 1 1 1 0 Sigma 54 modulation/S30EA ribosomal protein C terminus CDC27 PF09507.10 ETO05693.1 - 0.15 11.4 18.8 0.17 11.2 18.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CNDH2_C PF16858.5 ETO05693.1 - 0.39 10.5 17.1 0.49 10.2 17.1 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term GOLD_2 PF13897.6 ETO05693.1 - 1.4 9.4 7.6 0.22 12.0 3.1 2.0 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking Nop14 PF04147.12 ETO05693.1 - 1.4 7.1 22.8 1.8 6.7 22.8 1.1 1 0 0 1 1 1 0 Nop14-like family CLN3 PF02487.17 ETO05693.1 - 1.4 7.9 2.8 2.4 7.1 2.8 1.5 1 0 0 1 1 1 0 CLN3 protein Tristanin_u2 PF16638.5 ETO05693.1 - 3 8.7 9.1 6.1 7.7 9.1 1.5 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers Myc_N PF01056.18 ETO05693.1 - 3.9 7.3 11.8 7.6 6.3 11.8 1.5 1 0 0 1 1 1 0 Myc amino-terminal region Zip PF02535.22 ETO05693.1 - 4.3 6.4 5.4 5.2 6.2 5.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CENP-B_dimeris PF09026.10 ETO05693.1 - 4.4 7.7 16.8 0.6 10.5 11.9 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain EBV-NA3 PF05009.12 ETO05693.1 - 5.4 6.5 6.5 8.3 5.8 6.5 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Cwf_Cwc_15 PF04889.12 ETO05693.1 - 9.1 5.9 27.2 16 5.1 27.2 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein ALG3 PF05208.13 ETO05694.1 - 5.1e-124 414.3 26.8 5.1e-124 414.3 26.8 2.1 2 0 0 2 2 2 1 ALG3 protein DUF4661 PF15576.6 ETO05694.1 - 0.4 10.6 3.1 0.76 9.6 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) DUF4770 PF15994.5 ETO05694.1 - 4.7 7.4 12.1 5.7 7.1 10.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) ORF6N PF10543.9 ETO05694.1 - 7.1 6.9 7.9 12 6.2 4.5 2.4 2 0 0 2 2 2 0 ORF6N domain DDHD PF02862.17 ETO05696.1 - 0.00098 19.3 18.3 0.03 14.5 0.3 3.4 3 0 0 3 3 3 3 DDHD domain TFIIA PF03153.13 ETO05696.1 - 0.0017 18.4 61.2 0.037 14.0 10.4 3.3 3 0 0 3 3 3 3 Transcription factor IIA, alpha/beta subunit NTP_transf_8 PF12281.8 ETO05696.1 - 0.031 14.3 2.9 0.082 12.9 2.3 1.9 2 0 0 2 2 2 0 Nucleotidyltransferase DUF3801 PF12687.7 ETO05696.1 - 0.21 11.6 31.2 0.011 15.8 1.5 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3801) Velvet PF11754.8 ETO05696.1 - 0.23 11.4 29.9 0.76 9.7 0.5 3.5 3 0 0 3 3 3 0 Velvet factor Spt20 PF12090.8 ETO05696.1 - 0.41 10.2 67.9 0.061 12.9 15.9 3.4 3 0 0 3 3 3 0 Spt20 family Mitofilin PF09731.9 ETO05696.1 - 1.7 7.4 36.7 0.024 13.5 4.8 3.1 3 0 0 3 3 3 0 Mitochondrial inner membrane protein Neur_chan_memb PF02932.16 ETO05696.1 - 3.7 7.5 26.1 1.6 8.7 2.5 3.3 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region EPL1 PF10513.9 ETO05696.1 - 4.5 7.6 28.8 0.06 13.7 2.1 3.8 3 0 0 3 3 3 0 Enhancer of polycomb-like GAGA_bind PF06217.12 ETO05696.1 - 8.1 6.6 29.0 1.2 9.4 3.4 3.3 3 0 0 3 3 3 0 GAGA binding protein-like family PH_2 PF08458.10 ETO05698.1 - 0.04 14.3 0.4 0.15 12.4 0.1 2.3 2 0 0 2 2 2 0 Plant pleckstrin homology-like region DUF4573 PF15140.6 ETO05699.1 - 0.011 15.5 0.1 0.017 14.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4573) DUF5105 PF17118.5 ETO05700.1 - 0.03 14.1 8.8 0.038 13.8 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5105) Hormone_6 PF00236.18 ETO05700.1 - 0.058 13.4 3.2 0.035 14.1 0.9 1.8 2 0 0 2 2 2 0 Glycoprotein hormone PTR2 PF00854.21 ETO05700.1 - 3.6 6.3 4.5 5.3 5.8 4.5 1.2 1 0 0 1 1 1 0 POT family Pkinase_Tyr PF07714.17 ETO05703.1 - 1e-42 146.2 0.0 1.2e-42 146.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO05703.1 - 5.3e-38 130.9 0.0 7.2e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO05703.1 - 9.2e-06 24.7 0.0 1.2e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO05703.1 - 1.1e-05 24.9 0.0 1.4e-05 24.6 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO05703.1 - 0.00074 19.5 0.1 0.0012 18.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO05703.1 - 0.00097 18.5 0.2 0.0013 18.1 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETO05703.1 - 0.054 13.1 0.1 0.22 11.1 0.1 1.9 1 1 1 2 2 2 0 RIO1 family Pkinase_Tyr PF07714.17 ETO05704.1 - 1.6e-06 27.6 0.3 0.033 13.5 0.0 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO05704.1 - 3.5e-06 26.6 0.1 0.00099 18.5 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain ABC1 PF03109.16 ETO05704.1 - 0.096 12.9 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 ABC1 family DUF4590 PF15257.6 ETO05704.1 - 4.4 7.3 6.2 12 5.8 6.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4590) Lectin_N PF03954.14 ETO05705.1 - 0.004 16.9 7.3 0.0042 16.8 3.2 2.1 1 1 1 2 2 2 1 Hepatic lectin, N-terminal domain UPF0242 PF06785.11 ETO05705.1 - 0.0092 16.1 12.6 0.13 12.3 0.5 2.1 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 ETO05705.1 - 0.019 14.3 3.4 0.027 13.8 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 ETO05705.1 - 0.027 14.5 7.6 0.032 14.3 3.0 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HALZ PF02183.18 ETO05705.1 - 0.028 14.7 0.2 0.063 13.5 0.2 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 ETO05705.1 - 0.029 14.8 11.5 2.4 8.6 0.4 3.4 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ZapB PF06005.12 ETO05705.1 - 0.038 14.4 13.3 24 5.5 13.3 3.0 1 1 0 1 1 1 0 Cell division protein ZapB Peptidase_C74 PF12387.8 ETO05705.1 - 0.052 13.0 0.1 0.069 12.6 0.1 1.2 1 0 0 1 1 1 0 Pestivirus NS2 peptidase zf-C4H2 PF10146.9 ETO05705.1 - 0.055 13.8 9.9 0.046 14.0 5.6 2.0 1 1 2 3 3 3 0 Zinc finger-containing protein DUF4618 PF15397.6 ETO05705.1 - 0.06 12.8 11.6 0.038 13.4 4.4 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) Tropomyosin_1 PF12718.7 ETO05705.1 - 0.068 13.3 13.7 0.33 11.1 6.0 2.5 2 1 0 2 2 2 0 Tropomyosin like TMF_DNA_bd PF12329.8 ETO05705.1 - 0.082 12.9 13.4 0.69 10.0 0.1 3.3 2 1 0 3 3 3 0 TATA element modulatory factor 1 DNA binding Cullin_binding PF03556.15 ETO05705.1 - 0.089 13.2 0.6 0.12 12.9 0.6 1.4 1 0 0 1 1 1 0 Cullin binding TPR_MLP1_2 PF07926.12 ETO05705.1 - 0.12 12.4 7.7 1.1 9.3 4.2 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Rootletin PF15035.6 ETO05705.1 - 0.14 12.1 9.4 0.26 11.3 9.4 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.21 ETO05705.1 - 0.2 11.8 9.3 3.2 7.9 0.8 3.5 2 1 1 3 3 3 0 bZIP transcription factor SlyX PF04102.12 ETO05705.1 - 0.21 12.2 3.4 6.4 7.5 0.1 3.0 2 1 1 3 3 3 0 SlyX DUF948 PF06103.11 ETO05705.1 - 0.22 11.8 2.9 1.1 9.6 0.2 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Fez1 PF06818.15 ETO05705.1 - 0.22 11.9 10.0 0.82 10.1 10.1 1.7 1 1 0 1 1 1 0 Fez1 Spc7 PF08317.11 ETO05705.1 - 0.23 10.3 12.1 0.65 8.8 6.3 2.0 1 1 0 2 2 2 0 Spc7 kinetochore protein ADIP PF11559.8 ETO05705.1 - 0.24 11.5 12.9 2 8.5 4.2 2.5 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding JIP_LZII PF16471.5 ETO05705.1 - 0.25 11.6 8.7 0.082 13.1 3.2 2.4 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II YabA PF06156.13 ETO05705.1 - 0.3 11.7 11.4 0.65 10.7 1.6 3.0 1 1 2 3 3 3 0 Initiation control protein YabA TACC_C PF05010.14 ETO05705.1 - 0.32 10.8 12.0 2 8.2 12.0 1.9 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Cnn_1N PF07989.11 ETO05705.1 - 0.37 11.0 10.7 1.3 9.2 6.1 2.7 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Taxilin PF09728.9 ETO05705.1 - 0.38 9.9 14.8 0.11 11.6 7.1 2.0 2 0 0 2 2 2 0 Myosin-like coiled-coil protein PHM7_cyt PF14703.6 ETO05705.1 - 0.44 10.8 6.2 0.21 11.8 2.5 2.1 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter APG6_N PF17675.1 ETO05705.1 - 0.63 10.6 10.8 5.9 7.4 9.0 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 ETO05705.1 - 0.64 9.5 4.9 0.81 9.2 4.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit bZIP_2 PF07716.15 ETO05705.1 - 0.65 10.1 6.8 0.29 11.2 2.5 2.5 2 1 1 3 3 3 0 Basic region leucine zipper ARD PF03079.14 ETO05705.1 - 0.7 10.1 4.0 0.65 10.2 2.6 1.6 1 1 0 1 1 1 0 ARD/ARD' family ETRAMP PF09716.10 ETO05705.1 - 1.6 8.9 8.5 2.7e+02 1.7 8.5 2.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TolA_bind_tri PF16331.5 ETO05705.1 - 1.9 8.6 5.9 4.2 7.5 2.7 2.7 2 1 0 2 2 2 0 TolA binding protein trimerisation HemX PF04375.14 ETO05705.1 - 2.3 7.4 6.9 1.2 8.4 1.9 1.9 1 1 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Jnk-SapK_ap_N PF09744.9 ETO05705.1 - 2.4 8.4 10.7 4 7.7 6.5 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMPIT PF07851.13 ETO05705.1 - 6 6.0 11.0 5 6.3 5.5 2.0 1 1 1 2 2 2 0 TMPIT-like protein Exostosin PF03016.15 ETO05706.1 - 0.0051 16.1 6.3 0.034 13.4 6.3 2.2 1 1 0 1 1 1 1 Exostosin family Cdd1 PF11731.8 ETO05706.1 - 0.089 13.0 0.6 0.64 10.3 1.0 2.1 2 0 0 2 2 2 0 Pathogenicity locus Zip PF02535.22 ETO05707.1 - 3.8e-10 39.5 7.5 2.2e-09 37.0 4.1 2.2 1 1 1 2 2 2 2 ZIP Zinc transporter 2OG-FeII_Oxy_5 PF13759.6 ETO05707.1 - 0.008 16.6 0.5 0.015 15.7 0.4 1.5 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase DUF848 PF05852.11 ETO05708.1 - 0.054 13.6 0.5 0.054 13.6 0.5 1.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) NIF PF03031.18 ETO05709.1 - 5.6e-21 74.9 0.0 8.5e-21 74.4 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase MS_channel PF00924.18 ETO05711.1 - 9.5e-07 28.6 5.5 2.6e-06 27.1 5.5 1.7 1 0 0 1 1 1 1 Mechanosensitive ion channel DUF512 PF04459.12 ETO05712.1 - 0.017 14.4 0.1 0.09 12.0 0.1 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF512) DUF2063 PF09836.9 ETO05712.1 - 0.022 15.0 0.2 6 7.2 0.0 3.9 5 0 0 5 5 5 0 Putative DNA-binding domain FAM176 PF14851.6 ETO05712.1 - 5.6 6.6 8.8 0.37 10.5 1.6 2.6 3 0 0 3 3 3 0 FAM176 family Ribonuc_red_2_N PF08471.10 ETO05712.1 - 7 6.9 7.1 16 5.8 0.8 3.3 3 0 0 3 3 3 0 Class II vitamin B12-dependent ribonucleotide reductase WD40 PF00400.32 ETO05714.1 - 1.7e-08 34.9 1.9 0.013 16.3 0.1 4.0 3 1 1 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05714.1 - 0.00032 21.0 0.4 0.46 10.8 0.1 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain ComGF PF15980.5 ETO05714.1 - 0.0084 16.4 0.1 0.011 16.1 0.1 1.3 1 0 0 1 1 1 1 Putative Competence protein ComGF RNA_pol_Rpb4 PF03874.16 ETO05715.1 - 2.3e-10 40.9 0.2 4.3e-10 40.0 0.1 1.5 2 0 0 2 2 2 1 RNA polymerase Rpb4 WD40 PF00400.32 ETO05716.1 - 4.4e-60 198.2 6.7 1e-09 38.8 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05716.1 - 2.8e-24 85.2 1.8 0.00028 21.1 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05716.1 - 3.9e-14 52.7 2.4 0.0002 20.8 0.2 3.6 1 1 3 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO05716.1 - 2.4e-11 43.2 0.6 0.22 10.4 0.0 5.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05716.1 - 2.6e-11 42.9 0.8 0.024 13.3 0.0 4.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO05716.1 - 2.9e-08 33.6 0.3 0.00028 20.5 0.0 1.9 1 1 1 2 2 2 2 PQQ-like domain Cytochrom_D1 PF02239.16 ETO05716.1 - 3.6e-07 29.0 1.2 0.095 11.2 0.0 3.4 1 1 3 4 4 4 4 Cytochrome D1 heme domain PD40 PF07676.12 ETO05716.1 - 1.8e-06 27.7 2.7 0.66 10.0 0.1 6.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO05716.1 - 3.1e-06 27.3 1.1 3.6 7.7 0.0 5.8 2 1 5 7 7 6 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO05716.1 - 0.0011 17.9 8.6 0.18 10.5 0.5 4.2 1 1 4 5 5 5 2 Nup133 N terminal like Me-amine-dh_H PF06433.11 ETO05716.1 - 0.0013 17.7 0.1 0.44 9.4 0.0 2.7 1 1 2 3 3 3 3 Methylamine dehydrogenase heavy chain (MADH) DUF5046 PF16465.5 ETO05716.1 - 0.002 17.6 0.0 0.011 15.3 0.0 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF5046) PALB2_WD40 PF16756.5 ETO05716.1 - 0.0021 17.0 0.8 16 4.2 0.0 4.5 1 1 4 5 5 5 0 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 ETO05716.1 - 0.016 15.1 0.1 26 5.0 0.0 4.1 5 0 0 5 5 5 0 PQQ enzyme repeat DUF4988 PF16378.5 ETO05716.1 - 0.022 14.4 0.6 7.2 6.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function Nrap_D5 PF17406.2 ETO05716.1 - 0.061 13.1 0.5 0.25 11.1 0.0 2.1 2 0 0 2 2 2 0 Nrap protein PAP/OAS1-like domain 5 Phage_CI_repr PF07022.13 ETO05716.1 - 0.11 12.6 0.0 5.2 7.2 0.0 2.8 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain Invas_SpaK PF03519.14 ETO05716.1 - 0.87 9.7 3.6 2.5 8.2 0.0 3.2 3 1 1 4 4 4 0 Invasion protein B family Pkinase PF00069.25 ETO05718.1 - 1.4e-05 24.6 0.0 1.7e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain ABC2_membrane_3 PF12698.7 ETO05718.1 - 0.0004 19.6 0.1 0.00049 19.3 0.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein Methyltransf_21 PF05050.12 ETO05719.1 - 5.3e-06 26.6 1.2 3.9e-05 23.8 1.2 2.0 1 1 0 1 1 1 1 Methyltransferase FkbM domain Zip PF02535.22 ETO05720.1 - 0.00012 21.4 2.9 0.00013 21.3 2.9 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Amnionless PF14828.6 ETO05720.1 - 0.00026 20.0 0.9 0.00035 19.6 0.9 1.2 1 0 0 1 1 1 1 Amnionless SID-1_RNA_chan PF13965.6 ETO05720.1 - 0.002 16.6 2.2 0.0022 16.5 2.2 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 MAP17 PF15807.5 ETO05720.1 - 0.0043 17.3 5.2 0.0076 16.5 5.2 1.4 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 V_ATPase_I PF01496.19 ETO05720.1 - 0.007 14.4 2.8 0.0078 14.2 2.8 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 ETO05720.1 - 0.0099 16.8 5.3 0.0099 16.8 5.3 2.5 1 1 0 2 2 2 1 Domain of unknown function (DUF4834) PTPRCAP PF15713.5 ETO05720.1 - 0.016 15.5 4.4 0.022 15.0 4.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated PA26 PF04636.13 ETO05720.1 - 0.022 13.7 3.1 0.028 13.4 3.1 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Otopetrin PF03189.13 ETO05720.1 - 0.023 13.5 2.0 0.026 13.4 2.0 1.3 1 0 0 1 1 1 0 Otopetrin CSG2 PF16965.5 ETO05720.1 - 0.025 13.5 1.9 0.038 12.9 1.9 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator FAM163 PF15069.6 ETO05720.1 - 0.027 14.9 0.7 0.033 14.7 0.7 1.2 1 0 0 1 1 1 0 FAM163 family O-antigen_lig PF13425.6 ETO05720.1 - 0.039 12.8 3.1 0.046 12.5 3.1 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Raftlin PF15250.6 ETO05720.1 - 0.04 12.7 6.6 0.042 12.6 6.6 1.1 1 0 0 1 1 1 0 Raftlin UPF0242 PF06785.11 ETO05720.1 - 0.049 13.7 0.5 0.067 13.3 0.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2852 PF11014.8 ETO05720.1 - 0.055 13.6 0.2 0.1 12.8 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) CLN3 PF02487.17 ETO05720.1 - 0.066 12.3 1.1 0.091 11.8 1.1 1.3 1 0 0 1 1 1 0 CLN3 protein OATP PF03137.20 ETO05720.1 - 0.08 11.2 0.4 0.11 10.8 0.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CPSF100_C PF13299.6 ETO05720.1 - 0.15 12.2 4.5 0.23 11.6 4.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC45 PF02724.14 ETO05720.1 - 0.2 9.9 6.4 0.21 9.8 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Serinc PF03348.15 ETO05720.1 - 0.3 10.0 1.8 0.37 9.7 1.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) rRNA_processing PF08524.11 ETO05720.1 - 0.67 10.0 13.6 1 9.4 13.6 1.2 1 0 0 1 1 1 0 rRNA processing HCO3_cotransp PF00955.21 ETO05720.1 - 0.75 8.5 5.1 0.96 8.2 5.1 1.2 1 0 0 1 1 1 0 HCO3- transporter family Cellulose_synt PF03552.14 ETO05720.1 - 0.76 8.2 3.2 0.87 8.0 3.2 1.1 1 0 0 1 1 1 0 Cellulose synthase Folate_carrier PF01770.18 ETO05720.1 - 0.82 8.3 5.3 1.8 7.2 5.3 1.6 1 1 0 1 1 1 0 Reduced folate carrier DUF2371 PF10177.9 ETO05720.1 - 1.2 9.3 3.6 4.3 7.5 3.5 2.0 1 1 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) RIFIN PF02009.16 ETO05720.1 - 1.2 9.0 7.5 1.6 8.6 7.5 1.1 1 0 0 1 1 1 0 Rifin GREB1 PF15782.5 ETO05720.1 - 1.3 6.0 8.4 1.4 5.9 8.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 ETO05720.1 - 1.9 8.5 8.0 2.8 7.9 8.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3807 PF12720.7 ETO05720.1 - 2.2 8.5 14.0 3.4 7.9 14.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) PNISR PF15996.5 ETO05720.1 - 2.2 8.5 11.9 3.1 8.0 11.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SLC12 PF03522.15 ETO05720.1 - 2.5 7.0 11.8 3.2 6.7 11.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Tim54 PF11711.8 ETO05720.1 - 2.9 6.6 9.8 3.6 6.3 9.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Tyrosinase PF00264.20 ETO05720.1 - 9.1 6.5 13.6 14 5.9 13.6 1.2 1 0 0 1 1 1 0 Common central domain of tyrosinase DUF4551 PF15087.6 ETO05720.1 - 9.7 4.9 11.9 12 4.6 11.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RabGAP-TBC PF00566.18 ETO05721.1 - 2.8e-14 53.3 4.8 2.8e-12 46.7 4.7 2.5 1 1 0 1 1 1 1 Rab-GTPase-TBC domain zf-B_box PF00643.24 ETO05721.1 - 3.5e-06 27.0 6.9 6e-06 26.3 6.9 1.4 1 0 0 1 1 1 1 B-box zinc finger DUF4291 PF14124.6 ETO05722.1 - 1.3e-51 175.1 0.4 1.7e-51 174.7 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) WD40 PF00400.32 ETO05723.1 - 1.4e-29 101.7 36.0 4.7e-09 36.7 0.2 7.3 6 2 1 7 7 7 5 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO05723.1 - 1.1e-06 28.2 3.5 2.6e-06 26.9 3.5 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO05723.1 - 0.00014 21.9 0.2 0.00039 20.5 0.1 1.7 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Nup160 PF11715.8 ETO05723.1 - 0.0067 15.1 3.1 0.18 10.4 0.0 3.9 3 2 2 6 6 6 1 Nucleoporin Nup120/160 Pentapeptide_3 PF13576.6 ETO05723.1 - 0.0068 16.5 3.0 0.014 15.5 1.0 2.5 2 1 0 2 2 2 1 Pentapeptide repeats (9 copies) DUF2286 PF10051.9 ETO05724.1 - 0.036 13.8 1.5 0.34 10.7 0.1 2.6 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2286) ELH PF02323.15 ETO05725.1 - 0.12 11.7 1.0 0.14 11.5 1.0 1.3 1 0 0 1 1 1 0 Egg-laying hormone precursor WD40 PF00400.32 ETO05726.1 - 1.6e-15 57.2 1.9 0.0013 19.5 0.2 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO05726.1 - 0.0017 18.3 0.3 0.14 12.2 0.0 2.4 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Nup160 PF11715.8 ETO05726.1 - 0.0026 16.5 0.9 0.54 8.8 0.0 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05726.1 - 0.0063 16.8 0.1 1.3 9.4 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain UPF0565 PF10561.9 ETO05727.1 - 5.1e-09 35.8 2.6 8.7e-07 28.4 2.6 2.4 1 1 1 2 2 2 2 Uncharacterised protein family UPF0565 FdhD-NarQ PF02634.15 ETO05728.1 - 0.086 12.5 0.2 0.11 12.1 0.2 1.1 1 0 0 1 1 1 0 FdhD/NarQ family E7 PF00527.18 ETO05728.1 - 0.14 12.3 1.5 0.22 11.7 1.0 1.5 1 1 0 1 1 1 0 E7 protein, Early protein DUF4131 PF13567.6 ETO05728.1 - 0.17 11.6 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) NHase_beta PF02211.15 ETO05728.1 - 0.99 9.4 3.0 17 5.3 0.0 2.4 1 1 0 2 2 2 0 Nitrile hydratase beta subunit zf-CCHC_3 PF13917.6 ETO05729.1 - 0.00051 20.0 0.2 0.0013 18.6 0.2 1.8 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ETO05729.1 - 0.0054 16.7 0.7 0.0087 16.1 0.7 1.3 1 0 0 1 1 1 1 Zinc knuckle PHF5 PF03660.14 ETO05729.1 - 0.016 15.4 0.4 0.024 14.8 0.4 1.4 1 0 0 1 1 1 0 PHF5-like protein zf-CCHC_4 PF14392.6 ETO05729.1 - 0.069 12.9 0.4 0.13 12.0 0.4 1.5 1 0 0 1 1 1 0 Zinc knuckle Ig_4 PF16680.5 ETO05729.1 - 0.54 10.6 0.1 0.54 10.6 0.1 3.2 3 1 0 3 3 3 0 T-cell surface glycoprotein CD3 delta chain Telethonin PF09470.10 ETO05729.1 - 2.5 8.0 7.8 0.3 11.0 0.7 2.6 2 1 1 3 3 3 0 Telethonin protein Chisel PF15355.6 ETO05730.1 - 0.00039 20.6 0.1 0.00039 20.6 0.1 2.6 2 1 0 2 2 2 1 Stretch-responsive small skeletal muscle X protein, Chisel DUF5427 PF10310.9 ETO05730.1 - 0.61 9.0 15.0 0.64 8.9 15.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) AAA_5 PF07728.14 ETO05731.1 - 1.5e-05 25.0 0.0 3.8e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 ETO05731.1 - 3.6e-05 23.2 0.8 8.2e-05 22.0 0.1 2.0 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_14 PF13173.6 ETO05731.1 - 5.9e-05 23.1 0.3 0.00024 21.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETO05731.1 - 7.1e-05 23.2 0.0 0.00016 22.1 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO05731.1 - 0.00016 21.3 0.0 0.0005 19.6 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETO05731.1 - 0.00027 21.5 0.0 0.00084 19.9 0.0 1.9 1 0 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 ETO05731.1 - 0.0029 18.0 0.0 0.063 13.7 0.0 3.0 3 0 0 3 3 3 1 RNA helicase DUF815 PF05673.13 ETO05731.1 - 0.0034 16.6 0.1 0.0069 15.6 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ETO05731.1 - 0.0039 17.5 0.1 0.034 14.4 0.0 2.4 2 0 0 2 2 2 1 AAA domain MCM PF00493.23 ETO05731.1 - 0.0041 16.2 0.2 0.036 13.2 0.0 2.4 2 1 1 3 3 3 1 MCM P-loop domain AAA_16 PF13191.6 ETO05731.1 - 0.0057 17.1 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Bac_DnaA PF00308.18 ETO05731.1 - 0.041 13.7 0.3 0.17 11.7 0.0 2.1 2 0 0 2 2 2 0 Bacterial dnaA protein AAA_2 PF07724.14 ETO05731.1 - 0.043 13.9 0.9 0.15 12.1 0.0 2.4 4 0 0 4 4 4 0 AAA domain (Cdc48 subfamily) Sigma54_activat PF00158.26 ETO05731.1 - 0.072 12.8 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 ETO05731.1 - 0.085 12.9 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ETO05731.1 - 0.11 12.4 0.2 0.49 10.3 0.0 2.2 2 0 0 2 2 2 0 NACHT domain ATPase_2 PF01637.18 ETO05731.1 - 0.24 11.3 0.0 0.24 11.3 0.0 3.1 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA PF00004.29 ETO05732.1 - 0.027 14.9 0.1 0.16 12.4 0.1 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO05732.1 - 0.028 14.7 0.0 0.15 12.3 0.0 2.5 1 0 0 1 1 1 0 AAA domain DUF938 PF06080.12 ETO05733.1 - 0.0088 15.8 0.1 0.012 15.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF938) SLED PF12140.8 ETO05734.1 - 0.019 15.4 1.1 0.1 13.1 0.2 2.2 1 1 1 2 2 2 0 SLED domain DUF5432 PF17497.2 ETO05735.1 - 0.15 12.2 0.9 0.29 11.3 0.0 1.9 3 0 0 3 3 3 0 Family of unknown function (DUF5432) Glyco_transf_8 PF01501.20 ETO05738.1 - 4.9e-06 26.3 6.6 4.9e-06 26.3 6.6 2.1 2 0 0 2 2 2 1 Glycosyl transferase family 8 Methyltransf_16 PF10294.9 ETO05738.1 - 0.011 15.5 0.4 0.028 14.1 0.4 1.7 1 0 0 1 1 1 0 Lysine methyltransferase Adeno_52K PF03052.15 ETO05738.1 - 0.11 11.9 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 Adenoviral protein L1 52/55-kDa LRR_6 PF13516.6 ETO05739.1 - 2e-07 30.5 24.8 0.0012 18.7 0.1 7.3 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 ETO05739.1 - 0.19 11.5 19.3 0.8 9.5 6.1 4.7 3 2 0 3 3 3 0 Leucine rich repeat LRR_1 PF00560.33 ETO05739.1 - 0.51 11.1 22.0 4.8 8.1 0.1 7.4 6 1 0 6 6 6 0 Leucine Rich Repeat CENP-B_dimeris PF09026.10 ETO05739.1 - 5.3 7.5 12.7 0.46 10.9 2.2 2.9 3 0 0 3 3 3 0 Centromere protein B dimerisation domain DUF1908 PF08926.11 ETO05740.1 - 0.076 12.1 0.2 0.12 11.4 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1908) Serinc PF03348.15 ETO05741.1 - 3 6.7 6.0 3.1 6.6 6.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 ETO05741.1 - 5.5 5.6 12.2 6 5.5 12.2 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO05741.1 - 7 4.8 20.9 7.7 4.7 20.9 1.0 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO05742.1 - 2.2e-50 167.5 14.4 1.3e-08 35.3 0.3 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05742.1 - 3.3e-20 72.2 0.4 0.0016 18.7 0.0 6.2 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05742.1 - 9.7e-10 37.9 0.1 0.35 9.8 0.0 5.3 2 1 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05742.1 - 1.3e-09 37.8 0.1 2.5e-05 23.8 0.0 3.2 1 1 1 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO05742.1 - 2.1e-05 23.2 0.8 0.049 12.2 0.2 3.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO05742.1 - 6.9e-05 21.7 4.5 1.1 7.9 0.0 4.6 3 1 1 5 5 5 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO05742.1 - 0.0002 21.0 0.0 0.00031 20.4 0.0 1.3 1 0 0 1 1 1 1 PQQ-like domain DUF5570 PF17731.1 ETO05742.1 - 0.00037 20.6 0.1 11 6.1 0.0 3.7 1 1 3 4 4 4 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO05742.1 - 0.00065 19.1 0.6 0.58 9.4 0.1 4.2 2 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal PQQ PF01011.21 ETO05742.1 - 0.0025 17.7 0.0 55 3.9 0.0 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat PD40 PF07676.12 ETO05742.1 - 0.0066 16.4 3.7 6.4 6.8 0.1 5.5 6 1 0 6 6 6 1 WD40-like Beta Propeller Repeat Me-amine-dh_H PF06433.11 ETO05742.1 - 0.059 12.2 0.0 0.4 9.5 0.0 2.2 2 1 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) DUF1513 PF07433.11 ETO05742.1 - 0.21 10.7 0.1 5.9 5.9 0.0 2.8 1 1 3 4 4 4 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETO05742.1 - 0.27 10.9 3.7 49 3.7 0.3 3.8 3 1 0 3 3 3 0 Proteasome subunit A N-terminal signature AI-2E_transport PF01594.16 ETO05742.1 - 0.3 10.2 4.6 0.062 12.4 1.3 1.5 2 0 0 2 2 2 0 AI-2E family transporter Ribosomal_S3Ae PF01015.18 ETO05743.1 - 3e-11 43.3 1.8 4.2e-11 42.8 1.8 1.2 1 0 0 1 1 1 1 Ribosomal S3Ae family DinI PF06183.13 ETO05743.1 - 0.053 13.9 0.0 0.12 12.7 0.0 1.6 1 0 0 1 1 1 0 DinI-like family DUF1087 PF06465.13 ETO05743.1 - 0.096 12.7 0.1 0.096 12.7 0.1 2.0 3 0 0 3 3 3 0 Domain of Unknown Function (DUF1087) FAM60A PF15396.6 ETO05744.1 - 0.33 10.9 12.7 0.38 10.7 12.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CSRNP_N PF16019.5 ETO05744.1 - 2.4 8.0 10.7 2.7 7.9 10.7 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PPL5 PF18168.1 ETO05744.1 - 2.9 7.1 11.6 3.4 6.9 11.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF789 PF05623.12 ETO05744.1 - 3 7.5 8.4 3.4 7.3 8.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) GAGA_bind PF06217.12 ETO05744.1 - 3.7 7.7 14.7 4.3 7.5 14.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family LCD1 PF09798.9 ETO05744.1 - 3.8 5.9 11.0 4.9 5.6 11.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Presenilin PF01080.17 ETO05744.1 - 5.8 5.6 11.2 6.5 5.4 11.2 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO05744.1 - 8.1 4.6 13.9 9.3 4.4 13.9 1.0 1 0 0 1 1 1 0 CDC45-like protein ETRAMP PF09716.10 ETO05745.1 - 0.0029 17.6 0.6 0.0054 16.8 0.6 1.6 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Vfa1 PF08432.10 ETO05745.1 - 0.01 16.2 5.7 0.012 16.0 5.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4820 PF16091.5 ETO05745.1 - 0.48 9.8 3.2 0.54 9.6 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Tubulin PF00091.25 ETO05746.1 - 3.7e-56 190.5 0.0 5.8e-56 189.8 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO05746.1 - 2.6e-28 98.7 0.0 4.9e-28 97.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ETO05746.1 - 0.044 13.5 0.0 0.085 12.5 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain Tubulin_2 PF13809.6 ETO05746.1 - 0.14 11.4 0.1 0.23 10.6 0.1 1.3 1 0 0 1 1 1 0 Tubulin like ECSIT PF06239.11 ETO05747.1 - 0.017 14.3 4.7 0.024 13.8 4.7 1.4 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway DSPn PF14671.6 ETO05747.1 - 0.3 11.5 5.6 0.4 11.1 5.3 1.4 1 1 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half Peptidase_M20 PF01546.28 ETO05748.1 - 5e-15 55.8 0.0 1.1e-08 35.0 0.0 2.1 2 0 0 2 2 2 2 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETO05748.1 - 4.5e-05 23.3 0.0 9.6e-05 22.3 0.0 1.6 1 0 0 1 1 1 1 Peptidase dimerisation domain CENP-T_C PF15511.6 ETO05748.1 - 0.099 12.8 0.0 0.19 11.9 0.0 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold SAM_1 PF00536.30 ETO05749.1 - 1.3e-07 32.0 0.1 2e-07 31.4 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO05749.1 - 0.0019 18.3 0.2 0.0037 17.3 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Sec62 PF03839.16 ETO05749.1 - 0.068 12.7 1.3 0.099 12.1 1.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Atrophin-1 PF03154.15 ETO05749.1 - 1.2 7.3 3.4 1.7 6.8 3.4 1.2 1 0 0 1 1 1 0 Atrophin-1 family WD40 PF00400.32 ETO05750.1 - 2.3e-14 53.5 21.7 3.6e-05 24.4 0.0 7.8 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05750.1 - 0.0062 16.8 0.1 0.11 12.8 0.0 2.9 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DASH_Dam1 PF08653.10 ETO05753.1 - 0.37 10.6 1.2 13 5.7 0.3 2.8 2 0 0 2 2 2 0 DASH complex subunit Dam1 Peptidase_M54 PF07998.11 ETO05755.1 - 0.0087 16.1 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M54 Clr5 PF14420.6 ETO05755.1 - 0.014 15.6 0.3 3.1 8.1 0.0 3.0 3 0 0 3 3 3 0 Clr5 domain HIP1_clath_bdg PF16515.5 ETO05756.1 - 6 7.5 30.1 0.59 10.8 2.3 3.5 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Cnd2 PF05786.14 ETO05757.1 - 7.2e-93 312.6 32.4 8.6e-78 262.8 26.6 2.1 2 0 0 2 2 2 2 Condensin complex subunit 2 HU-CCDC81_bac_2 PF18175.1 ETO05757.1 - 0.0018 18.1 0.1 0.08 12.8 0.0 2.7 2 0 0 2 2 2 1 CCDC81-like prokaryotic HU domain 2 CNDH2_N PF06278.11 ETO05757.1 - 0.0019 18.4 0.5 0.0019 18.4 0.5 3.5 4 0 0 4 4 4 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal UPF0242 PF06785.11 ETO05758.1 - 5.2e-06 26.7 1.0 6.6e-06 26.4 1.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus TACC_C PF05010.14 ETO05758.1 - 4.5e-05 23.3 8.0 5.5e-05 23.0 8.0 1.1 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TMPIT PF07851.13 ETO05758.1 - 9.6e-05 21.8 5.0 0.00016 21.1 5.0 1.3 1 0 0 1 1 1 1 TMPIT-like protein DUF724 PF05266.14 ETO05758.1 - 0.00016 21.6 1.0 0.0002 21.3 1.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF724) HemX PF04375.14 ETO05758.1 - 0.00017 21.0 1.9 0.00022 20.6 1.9 1.1 1 0 0 1 1 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Lipoprotein_7 PF01540.16 ETO05758.1 - 0.00023 20.6 1.0 0.00023 20.6 1.0 1.1 1 0 0 1 1 1 1 Adhesin lipoprotein GAS PF13851.6 ETO05758.1 - 0.00051 19.4 9.5 0.0007 19.0 9.5 1.1 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 ETO05758.1 - 0.00083 18.4 3.4 0.0011 18.0 3.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF812) Not3 PF04065.15 ETO05758.1 - 0.00089 18.8 7.9 0.0012 18.3 7.9 1.1 1 0 0 1 1 1 1 Not1 N-terminal domain, CCR4-Not complex component Atg14 PF10186.9 ETO05758.1 - 0.001 18.2 3.2 0.0013 17.8 3.2 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 ALIX_LYPXL_bnd PF13949.6 ETO05758.1 - 0.0011 18.4 5.7 0.0015 17.9 5.7 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV AI-2E_transport PF01594.16 ETO05758.1 - 0.0011 18.1 1.9 0.093 11.9 1.9 2.0 1 1 0 1 1 1 1 AI-2E family transporter DivIC PF04977.15 ETO05758.1 - 0.0013 18.5 9.6 0.004 16.9 4.9 2.5 1 1 1 2 2 2 1 Septum formation initiator DUF3450 PF11932.8 ETO05758.1 - 0.0015 17.9 10.1 0.0017 17.7 9.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3450) DUF677 PF05055.12 ETO05758.1 - 0.0017 17.3 0.1 0.0022 16.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF677) STAT_alpha PF01017.20 ETO05758.1 - 0.0027 17.6 11.3 0.014 15.3 11.7 1.7 1 1 0 1 1 1 1 STAT protein, all-alpha domain Fmp27_WPPW PF10359.9 ETO05758.1 - 0.0033 16.4 4.4 0.0042 16.0 4.4 1.1 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Rab5-bind PF09311.11 ETO05758.1 - 0.0044 16.5 8.0 0.0057 16.1 8.0 1.1 1 0 0 1 1 1 1 Rabaptin-like protein CENP-F_leu_zip PF10473.9 ETO05758.1 - 0.0052 16.8 11.1 0.0085 16.1 10.2 1.6 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 ETO05758.1 - 0.0054 15.4 2.3 0.0074 14.9 2.3 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A ATG16 PF08614.11 ETO05758.1 - 0.007 16.6 6.2 0.011 16.0 6.2 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF2353 PF09789.9 ETO05758.1 - 0.0073 15.7 6.7 0.0094 15.3 6.7 1.1 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) Phage_GP20 PF06810.11 ETO05758.1 - 0.0084 15.9 14.7 0.93 9.3 1.7 2.0 1 1 0 1 1 1 1 Phage minor structural protein GP20 BLOC1_2 PF10046.9 ETO05758.1 - 0.0094 16.2 10.9 0.059 13.7 2.4 2.2 1 1 1 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tropomyosin PF00261.20 ETO05758.1 - 0.0097 15.3 6.4 0.013 14.9 6.4 1.1 1 0 0 1 1 1 1 Tropomyosin CALCOCO1 PF07888.11 ETO05758.1 - 0.0097 14.8 3.5 0.012 14.5 3.5 1.1 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4337 PF14235.6 ETO05758.1 - 0.0098 16.0 1.0 0.02 15.0 1.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4337) EzrA PF06160.12 ETO05758.1 - 0.01 14.1 11.5 0.84 7.7 0.9 1.8 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA DLP_helical PF18709.1 ETO05758.1 - 0.011 14.9 3.6 0.015 14.5 3.6 1.1 1 0 0 1 1 1 0 Dynamin-like helical domain HMMR_N PF15905.5 ETO05758.1 - 0.012 15.2 6.1 0.016 14.7 6.1 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Spc7 PF08317.11 ETO05758.1 - 0.016 14.1 12.9 0.047 12.6 2.6 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein KASH_CCD PF14662.6 ETO05758.1 - 0.016 15.1 9.9 0.027 14.3 9.6 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH APG17 PF04108.12 ETO05758.1 - 0.016 14.4 8.2 0.047 12.8 8.4 1.4 1 1 0 1 1 1 0 Autophagy protein Apg17 HIP1_clath_bdg PF16515.5 ETO05758.1 - 0.016 15.8 8.9 0.029 15.0 8.6 1.6 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2570 PF10828.8 ETO05758.1 - 0.018 14.9 5.6 0.053 13.3 5.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2570) MCPsignal PF00015.21 ETO05758.1 - 0.018 14.9 0.2 0.023 14.5 0.2 1.2 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1664 PF07889.12 ETO05758.1 - 0.02 14.9 7.6 0.028 14.5 5.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.18 ETO05758.1 - 0.021 14.1 2.5 0.028 13.8 2.5 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF935 PF06074.12 ETO05758.1 - 0.023 13.4 0.9 0.03 13.1 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF935) DASH_Dad2 PF08654.10 ETO05758.1 - 0.024 15.0 5.1 0.71 10.3 2.6 2.3 1 1 1 2 2 2 0 DASH complex subunit Dad2 IFT57 PF10498.9 ETO05758.1 - 0.026 13.5 6.5 0.22 10.5 7.1 1.9 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Laminin_II PF06009.12 ETO05758.1 - 0.028 14.4 9.3 0.068 13.2 9.1 1.6 1 1 1 2 2 2 0 Laminin Domain II SURF4 PF02077.15 ETO05758.1 - 0.029 14.0 2.5 3.7 7.1 1.1 2.2 2 0 0 2 2 2 0 SURF4 family CCDC106 PF15794.5 ETO05758.1 - 0.04 13.6 4.9 0.054 13.2 4.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF4763 PF15960.5 ETO05758.1 - 0.045 13.1 6.6 0.054 12.8 6.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) SlyX PF04102.12 ETO05758.1 - 0.048 14.3 6.1 1.3 9.7 0.9 2.3 1 1 1 2 2 2 0 SlyX Seryl_tRNA_N PF02403.22 ETO05758.1 - 0.065 13.5 10.9 0.063 13.5 9.3 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF3584 PF12128.8 ETO05758.1 - 0.07 10.6 8.3 0.088 10.3 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) SHE3 PF17078.5 ETO05758.1 - 0.073 12.8 13.8 0.96 9.1 1.8 2.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Rx_N PF18052.1 ETO05758.1 - 0.077 13.3 2.3 0.14 12.4 2.3 1.5 1 0 0 1 1 1 0 Rx N-terminal domain Syntaxin-6_N PF09177.11 ETO05758.1 - 0.079 13.5 5.9 0.42 11.2 5.9 2.0 1 1 0 1 1 1 0 Syntaxin 6, N-terminal FlgN PF05130.12 ETO05758.1 - 0.11 13.0 5.8 0.16 12.5 5.8 1.2 1 0 0 1 1 1 0 FlgN protein ACT PF01842.25 ETO05758.1 - 0.11 12.3 0.1 0.38 10.6 0.0 2.0 2 0 0 2 2 1 0 ACT domain APG6_N PF17675.1 ETO05758.1 - 0.13 12.8 9.1 0.21 12.1 9.1 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region V_ATPase_I PF01496.19 ETO05758.1 - 0.15 9.9 5.1 0.21 9.5 5.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 ETO05758.1 - 0.16 12.1 9.1 0.3 11.1 9.0 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein kleA_kleC PF17383.2 ETO05758.1 - 0.18 12.2 0.9 0.43 10.9 0.6 1.7 1 1 0 1 1 1 0 Uncharacterized KorC regulated protein A DUF745 PF05335.13 ETO05758.1 - 0.19 11.5 2.6 0.25 11.0 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) FlaC_arch PF05377.11 ETO05758.1 - 0.2 12.1 8.4 0.23 11.9 5.8 2.3 1 1 1 2 2 1 0 Flagella accessory protein C (FlaC) TFR_dimer PF04253.15 ETO05758.1 - 0.22 11.6 4.4 0.3 11.2 2.2 2.0 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain Occludin_ELL PF07303.13 ETO05758.1 - 0.26 12.1 6.3 0.5 11.1 5.3 1.7 1 1 1 2 2 2 0 Occludin homology domain bZIP_1 PF00170.21 ETO05758.1 - 0.26 11.4 10.2 0.22 11.6 3.9 2.6 1 1 2 3 3 3 0 bZIP transcription factor Jnk-SapK_ap_N PF09744.9 ETO05758.1 - 0.26 11.5 9.8 0.38 11.0 9.8 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Snapin_Pallidin PF14712.6 ETO05758.1 - 0.26 11.7 6.8 0.47 10.9 6.8 1.5 1 0 0 1 1 1 0 Snapin/Pallidin UPF0449 PF15136.6 ETO05758.1 - 0.28 11.7 5.4 0.23 11.9 2.3 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF4446 PF14584.6 ETO05758.1 - 0.3 11.1 4.7 0.24 11.4 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) TBCC_N PF16752.5 ETO05758.1 - 0.31 11.5 9.8 0.58 10.6 9.4 1.7 1 1 0 1 1 1 0 Tubulin-specific chaperone C N-terminal domain ISG65-75 PF11727.8 ETO05758.1 - 0.38 9.9 4.6 0.54 9.5 4.6 1.1 1 0 0 1 1 1 0 Invariant surface glycoprotein GrpE PF01025.19 ETO05758.1 - 0.42 10.3 8.5 0.67 9.6 8.5 1.3 1 0 0 1 1 1 0 GrpE XhlA PF10779.9 ETO05758.1 - 0.44 10.8 11.0 0.37 11.0 8.0 2.2 1 1 1 2 2 2 0 Haemolysin XhlA T2SSF PF00482.23 ETO05758.1 - 0.45 10.5 0.0 0.45 10.5 0.0 1.9 3 0 0 3 3 1 0 Type II secretion system (T2SS), protein F TMF_DNA_bd PF12329.8 ETO05758.1 - 0.5 10.4 13.3 1.1 9.3 12.6 1.9 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding ZapB PF06005.12 ETO05758.1 - 0.52 10.8 10.4 3.4 8.2 10.4 2.2 1 1 0 1 1 1 0 Cell division protein ZapB Tex_N PF09371.10 ETO05758.1 - 0.53 9.9 7.7 0.75 9.4 0.4 2.1 1 1 1 2 2 2 0 Tex-like protein N-terminal domain Ax_dynein_light PF10211.9 ETO05758.1 - 0.73 9.8 10.6 1 9.3 9.7 1.7 1 1 1 2 2 2 0 Axonemal dynein light chain PRKG1_interact PF15898.5 ETO05758.1 - 0.8 10.6 9.5 1.3 10.0 9.2 1.4 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF16 PF01519.16 ETO05758.1 - 0.92 10.0 8.1 1.5 9.4 8.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 Prefoldin PF02996.17 ETO05758.1 - 0.99 9.3 9.4 3 7.8 3.2 2.4 1 1 2 3 3 3 0 Prefoldin subunit TSC22 PF01166.18 ETO05758.1 - 1 9.7 7.1 4.2 7.8 1.2 2.6 1 1 1 2 2 2 0 TSC-22/dip/bun family DHR10 PF18595.1 ETO05758.1 - 1.1 9.3 10.0 1.3 9.1 7.9 1.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF948 PF06103.11 ETO05758.1 - 1.1 9.5 7.1 0.97 9.7 2.3 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Cnn_1N PF07989.11 ETO05758.1 - 1.2 9.3 10.9 0.14 12.4 4.9 2.1 1 1 0 2 2 2 0 Centrosomin N-terminal motif 1 Rho_Binding PF08912.11 ETO05758.1 - 1.3 9.8 11.0 0.5 11.2 5.7 2.5 1 1 2 3 3 3 0 Rho Binding Swi5 PF07061.11 ETO05758.1 - 1.5 9.0 9.4 3.3 7.9 4.2 2.3 1 1 1 2 2 2 0 Swi5 DUF1043 PF06295.12 ETO05758.1 - 1.5 8.9 8.2 3.4 7.7 8.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Fib_alpha PF08702.10 ETO05758.1 - 1.8 8.8 10.6 8.2 6.6 10.6 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Drf_FH3 PF06367.16 ETO05758.1 - 1.9 8.0 12.6 0.24 11.0 2.4 2.2 1 1 1 2 2 2 0 Diaphanous FH3 Domain zf-C4H2 PF10146.9 ETO05758.1 - 2 8.7 7.1 3 8.1 7.1 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein NPV_P10 PF05531.12 ETO05758.1 - 2.3 8.8 10.5 44 4.6 10.5 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 ETO05758.1 - 2.5 8.5 9.9 13 6.3 4.5 2.8 1 1 1 2 2 2 0 Lipoprotein leucine-zipper DivIVA PF05103.13 ETO05758.1 - 2.7 8.1 10.8 12 6.0 6.1 2.1 1 1 1 2 2 2 0 DivIVA protein Sec20 PF03908.13 ETO05758.1 - 3.1 7.8 6.6 32 4.5 3.3 2.5 1 1 1 2 2 2 0 Sec20 Wbp11 PF09429.10 ETO05758.1 - 3.2 8.2 10.5 1.7 9.1 4.9 2.2 1 1 1 2 2 2 0 WW domain binding protein 11 Tup_N PF08581.10 ETO05758.1 - 3.2 8.1 12.8 2.5 8.4 0.7 2.2 1 1 1 2 2 2 0 Tup N-terminal HALZ PF02183.18 ETO05758.1 - 4.2 7.7 12.6 0.28 11.4 4.2 2.8 3 1 0 3 3 2 0 Homeobox associated leucine zipper YabA PF06156.13 ETO05758.1 - 4.8 7.9 9.0 59 4.4 9.0 2.2 1 1 0 1 1 1 0 Initiation control protein YabA Adaptin_binding PF10199.9 ETO05758.1 - 5 7.8 10.1 6.1 7.5 10.1 1.3 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 CbtB PF09489.10 ETO05758.1 - 5.2 7.3 8.0 0.42 10.8 1.6 2.3 2 1 1 3 3 2 0 Probable cobalt transporter subunit (CbtB) FlxA PF14282.6 ETO05758.1 - 6.9 6.7 13.9 9.2 6.3 11.1 2.0 1 1 1 2 2 2 0 FlxA-like protein YtxH PF12732.7 ETO05758.1 - 8.6 7.0 6.5 30 5.3 6.5 2.0 1 1 0 1 1 1 0 YtxH-like protein Kinesin PF00225.23 ETO05759.1 - 3.5e-20 72.2 0.3 2.1e-13 49.9 0.0 3.0 1 1 2 3 3 3 3 Kinesin motor domain DUF961 PF06125.11 ETO05759.1 - 0.012 16.0 0.0 1.2 9.5 0.0 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF961) DUF3638 PF12340.8 ETO05759.1 - 0.084 12.2 0.0 0.14 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3638) TPR_19 PF14559.6 ETO05760.1 - 1.9e-07 31.5 8.8 0.0021 18.5 0.5 4.5 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETO05760.1 - 0.0004 20.5 0.1 0.0024 18.0 0.3 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO05760.1 - 0.00085 19.5 0.5 18 6.0 0.1 5.6 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO05760.1 - 0.0029 17.7 2.1 0.3 11.4 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO05760.1 - 0.0068 17.1 2.7 6.1 8.0 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO05760.1 - 0.008 16.0 0.0 0.008 16.0 0.0 4.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO05760.1 - 0.011 16.0 4.1 3.7 7.9 0.0 4.5 3 1 1 4 4 4 0 Tetratricopeptide repeat PknG_TPR PF16918.5 ETO05760.1 - 0.012 14.4 0.1 0.076 11.7 0.1 2.0 2 0 0 2 2 2 0 Protein kinase G tetratricopeptide repeat TPR_11 PF13414.6 ETO05760.1 - 0.022 14.4 1.1 20 5.0 0.0 4.4 4 1 1 5 5 5 0 TPR repeat TPR_16 PF13432.6 ETO05760.1 - 0.031 14.9 0.5 0.15 12.7 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO05760.1 - 0.11 12.7 9.0 0.13 12.4 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO05760.1 - 0.11 12.8 0.1 0.11 12.8 0.1 3.9 5 0 0 5 5 4 0 Tetratricopeptide repeat Striatin PF08232.12 ETO05760.1 - 0.4 11.3 21.3 0.13 12.9 14.2 2.2 2 0 0 2 2 2 0 Striatin family Chordopox_A30L PF06015.12 ETO05760.1 - 0.97 9.3 4.0 3 7.8 4.0 1.8 1 0 0 1 1 1 0 Chordopoxvirus A30L protein TRAP_alpha PF03896.16 ETO05760.1 - 1.1 8.5 8.9 2.1 7.5 8.9 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit GREB1 PF15782.5 ETO05760.1 - 1.3 6.1 15.0 1.7 5.7 15.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4175 PF13779.6 ETO05760.1 - 1.3 6.8 13.9 2.2 6.1 13.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CDC45 PF02724.14 ETO05760.1 - 1.7 6.8 16.1 2.4 6.4 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Pep_deformylase PF01327.21 ETO05761.1 - 5.9e-29 100.7 0.0 7.2e-29 100.4 0.0 1.1 1 0 0 1 1 1 1 Polypeptide deformylase GrpE PF01025.19 ETO05762.1 - 0.054 13.2 0.2 0.076 12.7 0.2 1.2 1 0 0 1 1 1 0 GrpE GDI PF00996.18 ETO05763.1 - 7.7e-08 31.3 0.4 1.2e-07 30.7 0.4 1.3 1 0 0 1 1 1 1 GDP dissociation inhibitor DUF3834 PF12916.7 ETO05763.1 - 0.077 12.2 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3834) RT_RNaseH_2 PF17919.1 ETO05765.1 - 7.6e-20 70.8 0.2 1.4e-19 70.0 0.2 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETO05765.1 - 9.7e-11 41.9 0.1 2.6e-10 40.5 0.0 1.8 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase Pico_P2B PF01552.17 ETO05765.1 - 0.024 14.8 2.5 2.6 8.3 0.2 3.1 3 0 0 3 3 3 0 Picornavirus 2B protein TP6A_N PF04406.14 ETO05765.1 - 0.14 12.1 0.5 24 5.0 0.0 2.7 3 0 0 3 3 3 0 Type IIB DNA topoisomerase CpxA_peri PF16527.5 ETO05765.1 - 0.31 11.4 2.4 0.68 10.3 2.4 1.5 1 0 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain DUF2890 PF11081.8 ETO05766.1 - 0.065 13.4 0.0 0.087 12.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) BSP_II PF05432.11 ETO05766.1 - 1.4 8.5 11.4 0.98 9.1 10.0 1.4 1 1 1 2 2 2 0 Bone sialoprotein II (BSP-II) DUF2870 PF11069.8 ETO05768.1 - 1.6e-20 73.3 0.5 3.7e-20 72.1 0.5 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2870) DUF2721 PF11026.8 ETO05769.1 - 0.086 12.7 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) NST1 PF13945.6 ETO05770.1 - 0.93 9.6 8.6 1.1 9.3 8.6 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator CENP-P PF13096.6 ETO05772.1 - 0.041 13.6 1.0 0.14 11.9 1.0 1.8 1 1 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P Roc PF08477.13 ETO05773.1 - 1e-11 45.1 0.1 6.3e-11 42.5 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO05773.1 - 4.8e-11 42.5 1.9 1.1e-10 41.4 0.2 2.4 2 1 0 2 2 2 1 Ras family RsgA_GTPase PF03193.16 ETO05773.1 - 0.00016 21.6 0.9 0.2 11.6 0.0 2.5 3 0 0 3 3 3 2 RsgA GTPase Septin PF00735.18 ETO05773.1 - 0.011 15.0 0.0 0.019 14.2 0.0 1.5 1 0 0 1 1 1 0 Septin TniB PF05621.11 ETO05773.1 - 0.012 15.0 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 ETO05773.1 - 0.012 15.8 0.0 0.27 11.5 0.0 2.3 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 ETO05773.1 - 0.015 14.9 1.6 0.3 10.6 1.6 2.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO05773.1 - 0.087 12.9 0.0 0.18 11.9 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_14 PF13173.6 ETO05773.1 - 0.1 12.6 0.3 0.53 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain Tetraspanin PF00335.20 ETO05774.1 - 0.00012 21.8 16.9 0.00024 20.9 15.7 2.1 1 1 1 2 2 2 1 Tetraspanin family DUF3533 PF12051.8 ETO05775.1 - 0.76 8.6 3.3 1.3 7.9 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Lig_C PF18330.1 ETO05775.1 - 1.8 8.6 12.9 2.4 8.2 4.7 2.6 1 1 1 2 2 2 0 Ligase Pab1020 C-terminal region DUF948 PF06103.11 ETO05775.1 - 4 7.8 6.6 4.6 7.6 2.2 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ETO05775.1 - 5.2 7.1 19.3 1.3 9.1 10.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) WXG100 PF06013.12 ETO05775.1 - 6.5 7.1 10.4 3.1 8.1 1.6 2.5 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Golgin_A5 PF09787.9 ETO05775.1 - 7.7 5.9 35.1 5.4 6.4 14.8 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 Kelch_2 PF07646.15 ETO05776.1 - 3.5e-07 29.9 0.8 0.042 13.8 0.1 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 ETO05776.1 - 2.4e-06 27.4 0.4 0.11 12.5 0.6 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO05776.1 - 1.3e-05 25.3 2.5 0.0032 17.7 0.3 3.5 2 1 1 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO05776.1 - 1.5e-05 24.5 0.2 0.002 17.7 0.1 3.5 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO05776.1 - 2e-05 24.5 0.2 0.0013 18.7 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO05776.1 - 0.012 15.9 0.0 0.085 13.2 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain IL3Ra_N PF18611.1 ETO05776.1 - 0.027 14.4 2.2 0.027 14.4 2.2 1.9 2 0 0 2 2 2 0 IL-3 receptor alpha chain N-terminal domain PUB PF09409.10 ETO05777.1 - 0.11 12.5 3.0 0.39 10.7 3.0 1.9 1 1 0 1 1 1 0 PUB domain DUF1398 PF07166.11 ETO05778.1 - 0.013 15.6 1.6 0.02 14.9 0.1 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1398) DUF4375 PF14300.6 ETO05778.1 - 0.33 11.2 3.7 0.62 10.4 1.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) TFIID-18kDa PF02269.16 ETO05779.1 - 0.0022 18.0 0.5 0.0034 17.4 0.5 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit HOIP-UBA PF16678.5 ETO05779.1 - 0.15 12.0 0.0 0.24 11.4 0.0 1.3 1 0 0 1 1 1 0 HOIP UBA domain pair Phage_Mu_Gam PF07352.12 ETO05780.1 - 0.024 14.5 0.1 0.041 13.8 0.1 1.4 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein IBR PF01485.21 ETO05782.1 - 0.2 11.9 4.7 1 9.7 4.7 2.1 1 1 0 1 1 1 0 IBR domain, a half RING-finger domain Sigma54_DBD PF04552.13 ETO05785.1 - 0.023 14.4 0.5 0.034 13.9 0.1 1.5 2 0 0 2 2 2 0 Sigma-54, DNA binding domain Gp_dh_C PF02800.20 ETO05785.1 - 0.036 13.7 0.0 0.056 13.0 0.0 1.2 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain PPP1R35_C PF15503.6 ETO05787.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 1 regulatory subunit 35 C-terminus Cnd1 PF12717.7 ETO05788.1 - 6.3e-05 23.1 1.4 0.0045 17.0 0.1 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETO05788.1 - 0.0029 17.4 1.6 0.047 13.5 0.4 2.7 2 1 0 2 2 2 1 TATA-binding protein interacting (TIP20) HsdM_N PF12161.8 ETO05788.1 - 0.0063 17.1 1.1 0.012 16.3 0.3 1.8 1 1 1 2 2 2 1 HsdM N-terminal domain DIL PF01843.19 ETO05788.1 - 0.027 14.8 1.1 0.45 10.8 0.1 2.2 2 1 0 2 2 2 0 DIL domain Serine_rich PF08824.10 ETO05788.1 - 0.027 14.5 0.4 0.062 13.3 0.4 1.6 1 1 0 1 1 1 0 Serine rich protein interaction domain LLGL PF08366.13 ETO05788.1 - 0.068 13.5 0.1 0.11 12.8 0.1 1.4 1 0 0 1 1 1 0 LLGL2 HEAT PF02985.22 ETO05788.1 - 0.087 13.1 0.0 0.72 10.3 0.0 2.4 2 0 0 2 2 2 0 HEAT repeat Arm-DNA-bind_2 PF12167.8 ETO05788.1 - 0.094 12.6 0.5 15 5.6 0.0 2.9 4 0 0 4 4 4 0 Arm DNA-binding domain HrpJ PF07201.11 ETO05788.1 - 0.1 12.9 0.5 0.63 10.3 0.4 2.0 2 0 0 2 2 2 0 HrpJ-like domain ACT_3 PF10000.9 ETO05788.1 - 0.18 11.7 0.0 0.48 10.4 0.0 1.7 1 0 0 1 1 1 0 ACT domain Ku_PK_bind PF08785.11 ETO05788.1 - 0.38 10.9 3.5 3.2 7.9 0.2 2.9 1 1 1 2 2 2 0 Ku C terminal domain like ETC_C1_NDUFA4 PF04800.12 ETO05789.1 - 0.048 13.9 0.0 0.082 13.2 0.0 1.4 1 0 0 1 1 1 0 ETC complex I subunit conserved region RPA43_OB PF17875.1 ETO05790.1 - 0.018 15.7 1.6 0.024 15.3 1.6 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Presenilin PF01080.17 ETO05790.1 - 1.1 8.0 3.0 1.1 7.9 3.0 1.2 1 0 0 1 1 1 0 Presenilin S_2TMBeta PF18153.1 ETO05792.1 - 0.011 15.6 0.1 0.011 15.6 0.1 2.1 2 1 0 2 2 2 0 SMODS-associating 2TM, beta-strand rich effector domain GRASP55_65 PF04495.14 ETO05792.1 - 0.084 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 GRASP55/65 PDZ-like domain LLC1 PF14945.6 ETO05793.1 - 0.045 14.3 0.7 0.18 12.4 0.7 2.1 1 0 0 1 1 1 0 Normal lung function maintenance, Low in Lung Cancer 1 protein CPSase_L_D3 PF02787.19 ETO05793.1 - 0.081 13.3 11.8 0.033 14.5 2.8 3.5 2 1 1 3 3 3 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain E2F_CC-MB PF16421.5 ETO05793.1 - 7.4 7.0 16.7 0.59 10.5 3.5 4.0 3 1 0 3 3 3 0 E2F transcription factor CC-MB domain eIF-4B PF06273.11 ETO05793.1 - 8.5 5.3 8.1 16 4.4 8.1 1.5 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Spindle_Spc25 PF08234.12 ETO05794.1 - 0.026 14.7 0.6 0.46 10.7 0.1 2.7 3 0 0 3 3 3 0 Chromosome segregation protein Spc25 HSDR_N_2 PF13588.6 ETO05794.1 - 0.026 14.5 0.1 0.061 13.3 0.1 1.7 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Kelch_6 PF13964.6 ETO05795.1 - 6e-08 32.7 8.8 0.00039 20.6 0.1 5.0 4 2 1 5 5 5 2 Kelch motif U-box PF04564.15 ETO05795.1 - 7e-08 32.5 0.0 2.9e-07 30.5 0.0 2.2 1 1 0 1 1 1 1 U-box domain zf-U1 PF06220.12 ETO05795.1 - 5.2e-05 22.9 0.6 5.2e-05 22.9 0.6 2.1 2 0 0 2 2 2 1 U1 zinc finger TAF8_C PF10406.9 ETO05795.1 - 0.038 14.6 1.6 0.093 13.3 0.1 2.5 2 0 0 2 2 2 0 Transcription factor TFIID complex subunit 8 C-term Kelch_3 PF13415.6 ETO05795.1 - 0.046 14.0 0.0 12 6.4 0.0 3.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO05795.1 - 0.14 12.2 0.4 2.2 8.4 0.0 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF4763 PF15960.5 ETO05796.1 - 0.0008 18.8 6.3 0.0008 18.8 6.3 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4763) ERM PF00769.19 ETO05796.1 - 0.0022 17.9 6.3 0.0028 17.5 6.3 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family ING PF12998.7 ETO05796.1 - 0.009 16.6 9.7 0.052 14.1 9.7 2.1 1 1 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding Spc7 PF08317.11 ETO05796.1 - 0.021 13.7 16.0 0.076 11.9 6.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Lebercilin PF15619.6 ETO05796.1 - 0.028 14.1 12.9 0.051 13.2 12.9 1.3 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Exonuc_VII_L PF02601.15 ETO05796.1 - 0.061 12.9 3.8 0.077 12.6 3.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 ETO05796.1 - 0.072 13.2 15.9 0.14 12.2 15.8 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ax_dynein_light PF10211.9 ETO05796.1 - 0.08 12.9 18.4 15 5.4 18.4 2.2 1 1 0 1 1 1 0 Axonemal dynein light chain LMBR1 PF04791.16 ETO05796.1 - 0.14 11.1 3.5 0.16 10.9 3.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein NPV_P10 PF05531.12 ETO05796.1 - 0.16 12.5 6.0 0.65 10.5 2.0 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF1664 PF07889.12 ETO05796.1 - 0.19 11.7 9.7 2 8.5 2.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Laminin_II PF06009.12 ETO05796.1 - 0.22 11.5 7.5 0.47 10.5 6.0 2.0 1 1 1 2 2 2 0 Laminin Domain II She9_MDM33 PF05546.11 ETO05796.1 - 0.27 11.0 8.3 0.46 10.3 8.3 1.4 1 0 0 1 1 1 0 She9 / Mdm33 family FUSC PF04632.12 ETO05796.1 - 0.32 9.5 0.0 0.39 9.2 0.0 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.6 ETO05796.1 - 0.44 9.9 20.8 1.4 8.3 19.9 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 ETO05796.1 - 0.55 10.4 12.3 1.5 9.0 12.4 1.6 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) FAM76 PF16046.5 ETO05796.1 - 0.58 9.5 13.2 0.065 12.6 8.0 1.8 1 1 1 2 2 2 0 FAM76 protein DUF4337 PF14235.6 ETO05796.1 - 1.6 8.8 6.2 1.2 9.2 3.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DHR10 PF18595.1 ETO05796.1 - 1.6 8.8 16.0 1.3 9.1 6.8 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF724 PF05266.14 ETO05796.1 - 1.8 8.3 12.4 2.8 7.7 8.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF724) DivIC PF04977.15 ETO05796.1 - 1.8 8.4 14.0 1.8 8.4 0.9 2.8 1 1 1 2 2 2 0 Septum formation initiator Cauli_DNA-bind PF03310.13 ETO05796.1 - 1.9 8.6 7.1 0.45 10.6 3.7 1.7 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein BRE1 PF08647.11 ETO05796.1 - 2 8.5 17.1 3 8.0 6.1 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Seryl_tRNA_N PF02403.22 ETO05796.1 - 4.6 7.5 12.9 8.5 6.7 12.1 1.9 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Occludin_ELL PF07303.13 ETO05796.1 - 5.5 7.8 15.9 0.69 10.7 3.9 2.8 2 1 1 3 3 3 0 Occludin homology domain ATP-synt_G PF04718.15 ETO05799.1 - 0.0041 17.9 0.1 0.0059 17.4 0.1 1.3 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit Pkinase PF00069.25 ETO05800.1 - 1.2e-70 237.9 0.9 1.9e-70 237.2 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05800.1 - 1.1e-27 97.0 2.1 1.3e-26 93.5 2.1 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 ETO05801.1 - 7e-11 42.5 2.0 7.9e-06 26.5 0.4 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO05801.1 - 0.00041 19.1 0.2 0.18 10.4 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO05801.1 - 0.022 15.1 0.1 4.3 7.7 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain FixQ PF05545.11 ETO05802.1 - 0.18 11.8 0.1 0.18 11.8 0.1 2.6 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Lep_receptor_Ig PF06328.11 ETO05804.1 - 0.063 13.2 1.3 0.09 12.7 0.0 1.9 2 1 0 2 2 2 0 Ig-like C2-type domain Kelch_6 PF13964.6 ETO05804.1 - 0.096 13.0 0.0 0.44 10.9 0.0 2.0 2 0 0 2 2 2 0 Kelch motif Copper-bind PF00127.20 ETO05804.1 - 0.1 13.0 0.4 0.21 12.0 0.4 1.6 1 1 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family WD40 PF00400.32 ETO05806.1 - 6.3e-38 128.1 21.7 6e-07 30.1 0.1 7.3 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05806.1 - 4.4e-11 42.9 0.1 0.22 11.8 0.0 5.6 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05806.1 - 1.1e-10 40.8 1.2 0.17 10.5 0.1 5.9 3 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05806.1 - 0.00014 21.3 2.7 1.4 8.1 0.1 4.2 2 2 3 5 5 5 2 WD40-like domain zf-LITAF-like PF10601.9 ETO05809.1 - 0.11 12.8 0.1 0.21 11.9 0.1 1.5 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain PspA_IM30 PF04012.12 ETO05809.1 - 0.36 10.4 9.6 0.042 13.4 4.1 2.0 2 0 0 2 2 2 0 PspA/IM30 family RRM_1 PF00076.22 ETO05810.1 - 6.5e-11 41.9 0.1 1.1e-10 41.1 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CRAM_rpt PF07016.11 ETO05810.1 - 0.0019 17.9 1.6 6 6.8 0.0 3.9 3 1 1 4 4 4 2 Cysteine-rich acidic integral membrane protein precursor Chorion_1 PF01723.16 ETO05810.1 - 0.0081 16.1 0.4 0.34 10.8 0.1 2.1 1 1 1 2 2 2 1 Chorion protein RRM_occluded PF16842.5 ETO05810.1 - 0.042 13.7 0.0 0.072 13.0 0.0 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif HAD_SAK_2 PF18143.1 ETO05811.1 - 1.8e-17 64.0 0.0 5e-12 46.3 0.0 2.9 2 1 1 3 3 3 2 HAD domain in Swiss Army Knife RNA repair proteins DUF89 PF01937.19 ETO05812.1 - 0.021 13.8 0.5 0.025 13.6 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF89 Arch_flagellin PF01917.16 ETO05813.1 - 0.26 11.5 2.3 0.34 11.1 2.3 1.3 1 0 0 1 1 1 0 Archaebacterial flagellin Orf78 PF06024.12 ETO05813.1 - 0.5 10.7 3.8 1 9.7 3.8 1.6 1 0 0 1 1 1 0 Orf78 (ac78) Menin PF05053.13 ETO05813.1 - 1.3 7.3 6.7 1.3 7.3 6.7 1.1 1 0 0 1 1 1 0 Menin Methyltransf_25 PF13649.6 ETO05814.1 - 5.3e-05 23.8 0.0 0.022 15.4 0.0 2.9 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_12 PF08242.12 ETO05814.1 - 0.00069 20.3 0.1 1 10.2 0.0 2.7 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 ETO05814.1 - 0.045 13.6 0.0 0.12 12.2 0.0 1.9 1 1 0 1 1 1 0 Methyltransferase domain VRR_NUC PF08774.11 ETO05814.1 - 0.12 12.5 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 VRR-NUC domain Methyltransf_11 PF08241.12 ETO05814.1 - 0.15 12.7 0.0 5.3 7.8 0.0 2.6 2 0 0 2 2 2 0 Methyltransferase domain WD40 PF00400.32 ETO05815.1 - 2e-32 110.7 25.9 3.2e-06 27.8 0.2 5.8 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05815.1 - 1.1e-09 38.4 0.3 0.0059 16.9 0.0 4.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05815.1 - 6.9e-08 31.6 6.4 0.017 13.8 0.4 3.8 2 2 2 4 4 4 3 Nucleoporin Nup120/160 WYL_2 PF10902.8 ETO05815.1 - 0.0027 18.0 0.7 7 7.1 0.1 3.8 3 1 1 4 4 4 1 WYL_2, Sm-like SH3 beta-barrel fold WD40_like PF17005.5 ETO05815.1 - 0.0066 15.8 0.4 3.4 6.9 0.0 3.3 2 1 1 4 4 4 1 WD40-like domain W_rich_C PF07483.11 ETO05815.1 - 2.1 8.5 7.7 29 4.9 1.5 3.6 4 0 0 4 4 4 0 Tryptophan-rich Synechocystis species C-terminal domain WD40 PF00400.32 ETO05816.1 - 3.2e-15 56.2 13.3 8.8e-08 32.7 0.3 4.6 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO05816.1 - 0.089 11.4 0.7 1.6 7.3 0.0 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 LicD PF04991.13 ETO05817.1 - 0.002 18.3 0.8 0.0055 16.9 0.1 1.9 2 0 0 2 2 2 1 LicD family HTH_7 PF02796.15 ETO05818.1 - 0.0032 17.5 0.1 0.0099 15.9 0.1 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain of resolvase DsrC PF04358.13 ETO05818.1 - 0.033 14.7 0.4 0.033 14.7 0.4 2.6 3 0 0 3 3 3 0 DsrC like protein Glyco_hydro_125 PF06824.11 ETO05820.1 - 0.018 14.0 1.7 0.022 13.7 1.7 1.0 1 0 0 1 1 1 0 Metal-independent alpha-mannosidase (GH125) LRRC37AB_C PF14914.6 ETO05820.1 - 0.51 10.2 6.7 0.14 12.0 1.3 1.9 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain DUF3767 PF12597.8 ETO05820.1 - 5.1 7.0 7.3 0.36 10.7 0.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3767) Pkinase PF00069.25 ETO05821.1 - 6.7e-05 22.4 0.0 7.1e-05 22.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Kelch_6 PF13964.6 ETO05823.1 - 0.1 12.9 0.0 0.23 11.8 0.0 1.6 1 0 0 1 1 1 0 Kelch motif Raptor_N PF14538.6 ETO05825.1 - 2.7e-05 24.1 3.1 4.4e-05 23.5 3.1 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain Troponin PF00992.20 ETO05826.1 - 0.27 11.5 8.6 0.29 11.4 8.6 1.1 1 0 0 1 1 1 0 Troponin UCMA PF17085.5 ETO05826.1 - 0.43 10.6 8.3 0.47 10.5 8.3 1.1 1 0 0 1 1 1 0 Unique cartilage matrix associated protein CppA_N PF14506.6 ETO05827.1 - 0.013 15.6 4.3 0.022 14.8 4.3 1.4 1 0 0 1 1 1 0 CppA N-terminal Hemocyanin_M PF00372.19 ETO05828.1 - 0.012 14.8 0.4 0.019 14.2 0.4 1.3 1 0 0 1 1 1 0 Hemocyanin, copper containing domain Ank_3 PF13606.6 ETO05829.1 - 1e-05 25.5 0.3 0.00068 19.9 0.0 2.8 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETO05829.1 - 1.5e-05 25.2 0.1 3.6e-05 23.9 0.1 1.7 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO05829.1 - 0.0001 22.8 0.9 0.0017 18.9 0.2 2.0 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO05829.1 - 0.0013 19.3 0.1 0.0025 18.4 0.1 1.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO05829.1 - 0.027 14.9 0.0 0.076 13.5 0.0 1.8 2 0 0 2 2 2 0 Ankyrin repeat DUF3177 PF11375.8 ETO05829.1 - 0.062 13.1 0.1 0.078 12.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3177) HATPase_c_3 PF13589.6 ETO05830.1 - 3.4e-11 43.1 0.9 3.5e-11 43.1 0.9 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c PF02518.26 ETO05830.1 - 1.4e-09 38.4 0.4 1.6e-09 38.3 0.4 1.3 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase FbpA PF05833.11 ETO05832.1 - 3.4e-05 22.8 0.1 6.8e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Gemini_AL1 PF00799.20 ETO05832.1 - 0.0061 16.9 1.4 0.025 15.0 0.0 2.7 2 1 0 3 3 3 1 Geminivirus Rep catalytic domain HpaB PF03241.13 ETO05832.1 - 0.098 11.7 0.0 0.17 10.9 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase C terminal Tmemb_9 PF05434.11 ETO05833.1 - 0.00086 19.2 0.5 0.0016 18.4 0.3 1.5 1 1 0 1 1 1 1 TMEM9 Pex24p PF06398.11 ETO05833.1 - 0.053 12.5 0.1 0.077 12.0 0.1 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Shisa PF13908.6 ETO05833.1 - 0.17 12.1 2.1 0.33 11.2 2.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF3139 PF11337.8 ETO05833.1 - 2.9 8.6 6.1 19 6.0 6.1 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) DUF600 PF04634.12 ETO05834.1 - 0.029 14.4 0.4 0.099 12.7 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function, DUF600 Mucin PF01456.17 ETO05837.1 - 0.039 14.0 17.7 0.053 13.5 17.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 ETO05837.1 - 1 7.3 5.5 1.2 7.0 5.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein MGC-24 PF05283.11 ETO05837.1 - 3.3 8.1 7.2 5.5 7.4 7.2 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Yuri_gagarin PF15934.5 ETO05838.1 - 0.039 13.8 0.1 0.039 13.8 0.1 1.1 1 0 0 1 1 1 0 Yuri gagarin DUF16 PF01519.16 ETO05839.1 - 0.045 14.2 0.5 0.058 13.9 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF16 Arf PF00025.21 ETO05841.1 - 4e-15 55.7 5.4 1.3e-13 50.8 0.2 3.8 2 2 1 3 3 3 1 ADP-ribosylation factor family NAM-associated PF14303.6 ETO05841.1 - 0.017 15.8 19.2 0.017 15.8 19.2 4.7 3 1 0 3 3 3 0 No apical meristem-associated C-terminal domain Chisel PF15355.6 ETO05841.1 - 0.017 15.3 0.1 0.017 15.3 0.1 3.9 3 2 0 3 3 3 0 Stretch-responsive small skeletal muscle X protein, Chisel TMEM213 PF15192.6 ETO05841.1 - 0.046 13.7 0.2 0.2 11.6 0.2 2.1 1 0 0 1 1 1 0 TMEM213 family Saw1 PF11561.8 ETO05842.1 - 0.0014 18.3 0.3 0.0034 17.0 0.3 1.7 1 0 0 1 1 1 1 Single strand annealing-weakened 1 DUF3235 PF11574.8 ETO05842.1 - 0.061 14.2 4.1 0.17 12.8 4.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3235) PPR PF01535.20 ETO05843.1 - 2.5e-16 58.7 4.3 3.8e-05 23.7 0.1 4.6 4 0 0 4 4 4 4 PPR repeat PPR_2 PF13041.6 ETO05843.1 - 8.9e-15 54.6 17.4 3.7e-09 36.6 0.7 4.8 2 1 3 5 5 5 4 PPR repeat family PPR_3 PF13812.6 ETO05843.1 - 2.2e-14 53.3 8.3 2.5e-07 30.7 0.3 5.0 2 1 3 5 5 5 4 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO05843.1 - 2.5e-12 46.3 5.4 4.2e-05 23.2 0.0 4.9 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 ETO05843.1 - 3.2e-08 33.2 0.0 5.6e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP Rep_fac-A_C PF08646.10 ETO05845.1 - 5e-16 58.8 0.0 2.6e-15 56.4 0.0 1.9 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ETO05845.1 - 2.6e-08 33.7 0.0 7.8e-08 32.1 0.0 1.8 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ETO05845.1 - 0.0089 16.0 0.0 0.035 14.1 0.0 2.0 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain LRR_8 PF13855.6 ETO05845.1 - 0.064 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Leucine rich repeat Lectin_leg-like PF03388.13 ETO05846.1 - 3.4e-24 85.5 0.7 4.5e-13 49.1 0.0 2.1 1 1 1 2 2 2 2 Legume-like lectin family Bact_lectin PF18483.1 ETO05846.1 - 0.00052 20.1 2.8 0.001 19.2 2.8 1.7 1 1 0 1 1 1 1 Bacterial lectin Mito_carr PF00153.27 ETO05847.1 - 4.2e-22 77.9 1.9 3.9e-09 36.3 0.0 4.7 3 1 1 4 4 4 3 Mitochondrial carrier protein Wzz PF02706.15 ETO05847.1 - 0.06 13.7 1.3 0.32 11.3 0.1 2.5 3 0 0 3 3 3 0 Chain length determinant protein Maf1 PF09174.10 ETO05847.1 - 0.16 12.1 3.0 0.14 12.3 0.4 2.0 2 1 0 2 2 2 0 Maf1 regulator DUF501 PF04417.12 ETO05847.1 - 0.17 11.7 0.6 0.45 10.3 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF501) Acetyltransf_9 PF13527.7 ETO05848.1 - 0.017 15.2 0.0 2 8.5 0.0 2.4 2 1 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO05848.1 - 0.08 13.2 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family DSPc PF00782.20 ETO05849.1 - 4.6e-28 97.7 1.4 5e-28 97.6 0.1 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 ETO05849.1 - 4.9e-11 43.1 0.5 5.2e-10 39.8 0.2 2.5 2 2 0 2 2 2 1 Rhodanese-like domain PTPlike_phytase PF14566.6 ETO05849.1 - 6.5e-05 23.1 0.2 0.0002 21.5 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 ETO05849.1 - 0.00058 20.1 0.1 0.002 18.4 0.0 2.0 2 0 0 2 2 2 1 Rit1 DUSP-like domain Y_phosphatase2 PF03162.13 ETO05849.1 - 0.0028 17.2 0.4 0.0072 15.9 0.1 1.8 2 0 0 2 2 2 1 Tyrosine phosphatase family Y_phosphatase PF00102.27 ETO05849.1 - 0.0061 16.2 0.0 0.013 15.1 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase WD40 PF00400.32 ETO05850.1 - 7.2e-38 127.9 24.6 2.4e-06 28.2 0.8 7.3 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05850.1 - 9e-14 51.5 4.8 0.0072 16.6 0.0 5.4 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05850.1 - 1.5e-09 37.1 11.4 0.0099 14.6 0.6 5.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO05850.1 - 6.4e-06 26.2 6.1 0.036 13.9 0.3 4.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Read-through PF16814.5 ETO05850.1 - 0.0037 17.1 2.4 1.3 8.8 0.3 2.7 2 1 1 3 3 3 2 Read-through domain DUF4979 PF16351.5 ETO05850.1 - 0.28 11.4 5.9 1.6 9.0 0.7 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO05851.1 - 1.1e-10 41.9 6.0 0.00059 20.6 0.6 4.1 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO05851.1 - 0.0091 14.7 0.1 0.11 11.1 0.1 1.9 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Sec23_trunk PF04811.15 ETO05851.1 - 0.12 11.9 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 Sec23/Sec24 trunk domain AXH PF08517.12 ETO05852.1 - 0.00049 20.6 0.1 0.0034 17.9 0.1 2.2 1 1 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) Intein_splicing PF14890.6 ETO05852.1 - 0.0005 20.0 0.1 0.0025 17.7 0.1 2.1 1 1 0 1 1 1 1 Intein splicing domain PT-HINT PF07591.11 ETO05852.1 - 0.0013 19.0 0.5 0.0099 16.1 0.2 2.5 2 1 0 2 2 2 1 Pretoxin HINT domain Hom_end_hint PF05203.16 ETO05852.1 - 0.019 14.9 0.1 0.038 13.9 0.1 1.5 1 0 0 1 1 1 0 Hom_end-associated Hint Hint_2 PF13403.6 ETO05852.1 - 0.045 14.1 0.0 3.6 7.9 0.0 2.4 2 0 0 2 2 2 0 Hint domain WD40 PF00400.32 ETO05853.1 - 1e-55 184.4 14.5 2.1e-08 34.7 0.1 8.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05853.1 - 2.4e-29 101.5 3.3 0.00033 20.9 0.0 8.5 2 1 6 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05853.1 - 2.7e-12 46.3 0.1 0.83 8.5 0.0 6.5 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05853.1 - 3.3e-08 33.2 21.3 0.0036 16.7 0.2 5.9 2 2 2 6 6 6 4 WD40-like domain Nup160 PF11715.8 ETO05853.1 - 2.6e-07 29.7 2.7 1.2 7.7 0.0 5.7 3 3 3 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO05853.1 - 0.00084 19.2 1.4 13 5.9 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO05853.1 - 0.0013 18.5 4.2 0.6 10.1 0.0 5.9 7 0 0 7 7 7 1 PQQ enzyme repeat BBS2_Mid PF14783.6 ETO05853.1 - 0.0025 17.8 6.6 5.7 7.0 0.0 6.0 5 2 1 6 6 6 1 Ciliary BBSome complex subunit 2, middle region Kelch_5 PF13854.6 ETO05853.1 - 0.0059 16.6 2.1 11 6.2 0.2 4.4 4 0 0 4 4 4 1 Kelch motif PALB2_WD40 PF16756.5 ETO05853.1 - 0.0069 15.4 3.7 0.25 10.2 0.1 4.3 4 1 1 5 5 5 1 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO05853.1 - 0.011 14.3 0.3 3.6 6.0 0.0 2.8 1 1 1 2 2 2 0 Cytochrome D1 heme domain Kelch_1 PF01344.25 ETO05853.1 - 0.06 12.9 3.8 0.3 10.7 0.6 3.5 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO05853.1 - 0.18 11.8 7.0 14 5.8 0.0 5.3 5 1 0 5 5 5 0 Kelch motif LPD25 PF18840.1 ETO05853.1 - 0.32 11.6 3.0 0.98 10.0 3.0 1.8 1 0 0 1 1 1 0 Large polyvalent protein associated domain 25 WD40 PF00400.32 ETO05854.1 - 7.6e-32 108.9 24.2 1e-06 29.3 1.8 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05854.1 - 1.5e-11 44.4 1.0 0.055 13.8 0.0 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05854.1 - 6.9e-08 31.6 6.4 0.0013 17.5 0.8 4.2 3 2 1 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05854.1 - 1.6e-05 24.4 11.2 0.0009 18.7 0.9 4.2 3 1 2 5 5 5 2 WD40-like domain zf-TRAF PF02176.18 ETO05854.1 - 0.0015 19.2 2.9 0.0015 19.2 2.9 2.3 1 1 0 1 1 1 1 TRAF-type zinc finger Cathelicidins PF00666.17 ETO05854.1 - 0.078 13.3 0.4 0.078 13.3 0.4 2.3 3 0 0 3 3 3 0 Cathelicidin Exonuc_VII_L PF02601.15 ETO05854.1 - 0.11 12.1 0.6 0.15 11.6 0.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Laminin_II PF06009.12 ETO05854.1 - 3.6 7.6 6.9 8 6.5 6.5 1.7 1 1 0 1 1 1 0 Laminin Domain II WD40 PF00400.32 ETO05855.1 - 6.1e-40 134.5 26.3 1.4e-06 28.9 0.4 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05855.1 - 3.5e-12 46.4 1.8 0.076 13.3 0.0 6.0 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05855.1 - 7.9e-08 31.4 6.3 0.11 11.1 0.1 4.9 1 1 2 4 4 4 4 Nucleoporin Nup120/160 DCX PF03607.17 ETO05855.1 - 0.052 13.7 1.4 4.1 7.6 0.0 3.3 4 0 0 4 4 4 0 Doublecortin WD40 PF00400.32 ETO05856.1 - 1.4e-104 339.0 43.4 1.7e-09 38.1 0.4 15.0 14 1 1 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05856.1 - 2.9e-27 94.8 13.8 0.1 12.9 0.0 12.8 1 1 14 15 15 15 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05856.1 - 3.1e-19 69.1 1.5 0.45 9.4 0.0 11.4 2 2 10 13 13 13 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05856.1 - 2.2e-13 50.2 10.4 0.037 13.3 0.2 7.2 2 1 5 8 8 8 5 WD40-like domain Nup160 PF11715.8 ETO05856.1 - 3e-12 46.0 27.4 0.23 10.0 0.2 11.6 3 2 8 12 12 12 7 Nucleoporin Nup120/160 POLO_box PF00659.18 ETO05856.1 - 1.7e-07 31.3 10.3 0.36 11.1 0.2 9.5 8 3 2 10 10 10 1 POLO box duplicated region Str_synth PF03088.16 ETO05856.1 - 3.6e-07 30.2 0.8 5.6 7.2 0.0 7.7 6 3 3 9 9 9 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO05856.1 - 8.6e-05 21.2 6.9 3 6.3 0.0 5.3 3 2 1 5 5 5 3 Cytochrome D1 heme domain DUF5046 PF16465.5 ETO05856.1 - 9.9e-05 21.9 0.0 1.3 8.4 0.0 4.4 2 2 3 5 5 5 1 Domain of unknown function (DUF5046) PD40 PF07676.12 ETO05856.1 - 0.00012 21.9 18.0 13 5.9 0.0 10.3 12 0 0 12 12 11 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO05856.1 - 0.0086 15.2 0.1 4.3 6.3 0.0 3.4 2 2 0 4 4 4 1 VID27 C-terminal WD40-like domain DUF5319 PF17252.2 ETO05856.1 - 0.084 13.1 0.0 27 5.0 0.0 3.5 2 1 1 3 3 3 0 Family of unknown function (DUF5319) Ribosomal_L28 PF00830.19 ETO05856.1 - 0.086 13.0 1.0 4.2 7.6 0.1 4.2 5 0 0 5 5 4 0 Ribosomal L28 family DUF1938 PF09153.10 ETO05856.1 - 0.19 11.8 1.6 1e+02 3.1 0.0 4.4 4 1 1 5 5 5 0 Domain of unknown function (DUF1938) WD40 PF00400.32 ETO05857.1 - 4.4e-37 125.4 16.3 3.3e-07 30.9 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05857.1 - 1.4e-15 57.4 5.2 0.03 14.6 0.1 6.4 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05857.1 - 1.3e-08 34.2 0.8 0.079 11.9 0.1 4.4 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05857.1 - 9.2e-06 24.6 5.9 0.25 9.9 0.0 4.5 2 2 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05857.1 - 1.3e-05 24.7 4.5 0.00028 20.3 1.4 2.7 1 1 1 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO05857.1 - 2.5e-05 23.0 2.7 0.21 10.1 0.2 3.3 1 1 3 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO05857.1 - 7.9e-05 22.5 4.8 1.1 9.2 0.1 5.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Peptidase_S9_N PF02897.15 ETO05857.1 - 0.0079 15.0 0.3 0.59 8.9 0.0 2.4 1 1 1 2 2 2 1 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF3748 PF12566.8 ETO05857.1 - 0.013 15.4 0.1 4.3 7.3 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3748) DPPIV_N PF00930.21 ETO05857.1 - 0.022 13.5 0.0 0.62 8.8 0.0 2.9 2 1 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region ubiquitin PF00240.23 ETO05857.1 - 0.026 14.2 0.2 4.8 7.0 0.0 3.3 3 0 0 3 3 3 0 Ubiquitin family Flavokinase PF01687.17 ETO05858.1 - 0.0095 16.2 0.6 0.52 10.6 0.1 2.1 2 0 0 2 2 2 2 Riboflavin kinase YebG PF07130.12 ETO05858.1 - 0.029 14.2 0.1 0.05 13.4 0.1 1.4 1 0 0 1 1 1 0 YebG protein CH PF00307.31 ETO05861.1 - 5e-42 142.5 2.4 8.6e-20 71.0 0.3 3.0 3 0 0 3 3 3 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO05861.1 - 0.00023 21.0 0.0 0.0024 17.7 0.0 2.2 2 0 0 2 2 2 1 CAMSAP CH domain HATPase_c PF02518.26 ETO05862.1 - 0.00019 21.9 0.1 0.00022 21.7 0.1 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO05862.1 - 0.0025 17.7 0.2 0.003 17.4 0.2 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase WD40 PF00400.32 ETO05863.1 - 3.7e-08 33.9 3.2 0.00052 20.8 0.8 4.1 2 2 1 3 3 3 2 WD domain, G-beta repeat DUF4221 PF13970.6 ETO05863.1 - 0.014 14.9 0.2 0.047 13.3 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Bac_surface_Ag PF01103.23 ETO05864.1 - 0.043 13.3 3.4 0.052 13.0 3.4 1.1 1 0 0 1 1 1 0 Surface antigen DAP_B PF07930.12 ETO05864.1 - 4 7.4 8.8 0.41 10.6 4.4 1.6 2 0 0 2 2 2 0 D-aminopeptidase, domain B zf_ZIC PF18366.1 ETO05865.1 - 0.071 13.2 0.6 19 5.5 0.0 2.7 2 0 0 2 2 2 0 Zic proteins zinc finger domain Cadherin_pro PF08758.11 ETO05866.1 - 0.018 15.2 0.8 0.025 14.8 0.8 1.4 1 1 0 1 1 1 0 Cadherin prodomain like GH43_C PF16369.5 ETO05867.1 - 0.081 13.6 1.5 0.12 13.0 0.6 1.7 2 0 0 2 2 2 0 C-terminal lipocalin-like domain Lipoprotein_3 PF00938.17 ETO05867.1 - 0.46 10.7 2.6 0.92 9.7 0.6 2.1 2 0 0 2 2 2 0 Lipoprotein Ribosomal_L23 PF00276.20 ETO05868.1 - 2.1e-09 37.6 1.1 2.1e-09 37.6 1.1 2.0 3 0 0 3 3 3 1 Ribosomal protein L23 Nop25 PF09805.9 ETO05869.1 - 1e-09 39.0 5.6 1e-09 39.0 5.6 2.8 2 1 1 3 3 3 1 Nucleolar protein 12 (25kDa) DUF3533 PF12051.8 ETO05869.1 - 0.43 9.4 0.7 0.57 9.1 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) Acetyltransf_11 PF13720.6 ETO05869.1 - 1.6 9.3 6.2 15 6.2 0.3 2.8 2 1 1 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 RVT_1 PF00078.27 ETO05870.1 - 1.1e-29 103.6 2.0 2e-29 102.7 2.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Aldo_ket_red PF00248.21 ETO05871.1 - 0.0051 16.0 0.6 0.0054 16.0 0.6 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Mnd1 PF03962.15 ETO05871.1 - 0.015 15.6 4.9 0.12 12.6 1.2 2.7 1 1 1 2 2 2 0 Mnd1 HTH domain DUF4375 PF14300.6 ETO05871.1 - 0.043 14.1 2.0 0.059 13.6 1.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4375) GerA PF03323.13 ETO05871.1 - 0.61 8.5 2.8 0.67 8.4 2.8 1.1 1 0 0 1 1 1 0 Bacillus/Clostridium GerA spore germination protein Ribonuc_2-5A PF06479.12 ETO05871.1 - 0.81 9.9 5.6 1.8 8.7 5.6 1.7 1 1 0 1 1 1 0 Ribonuclease 2-5A WD40 PF00400.32 ETO05873.1 - 0.00057 20.6 0.2 0.0024 18.6 0.4 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat Bacteriocin_IIi PF11758.8 ETO05874.1 - 0.068 13.0 1.2 0.38 10.6 0.2 2.2 2 0 0 2 2 2 0 Aureocin-like type II bacteriocin YrpD PF15493.6 ETO05874.1 - 0.092 12.6 1.7 0.11 12.3 1.7 1.3 1 1 0 1 1 1 0 Domain of unknown function, YrpD DSPc PF00782.20 ETO05876.1 - 1.3e-11 44.5 0.2 2.1e-11 43.8 0.2 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO05876.1 - 0.0029 17.6 0.0 0.0037 17.3 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF1041 PF06292.17 ETO05876.1 - 0.029 14.8 0.3 0.083 13.3 0.3 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1041) Y_phosphatase PF00102.27 ETO05876.1 - 0.077 12.5 0.8 0.47 10.0 0.7 2.0 1 1 0 1 1 1 0 Protein-tyrosine phosphatase UBA_e1_thiolCys PF10585.9 ETO05877.1 - 1.9e-70 237.6 7.6 1.9e-70 237.6 7.6 2.4 3 0 0 3 3 3 1 Ubiquitin-activating enzyme active site ThiF PF00899.21 ETO05877.1 - 0.003 16.9 0.0 0.0052 16.2 0.0 1.4 1 0 0 1 1 1 1 ThiF family DUF4340 PF14238.6 ETO05877.1 - 0.026 14.5 1.0 0.075 13.1 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4340) FliD_N PF02465.18 ETO05877.1 - 1.6 9.5 5.9 3.9 8.2 0.4 2.6 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ThiF PF00899.21 ETO05878.1 - 8.3e-49 166.1 0.0 8.9e-48 162.8 0.0 2.1 2 1 0 2 2 2 1 ThiF family E1_4HB PF16191.5 ETO05878.1 - 4.4e-06 26.8 0.0 1.4e-05 25.2 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin-activating enzyme E1 four-helix bundle E1_FCCH PF16190.5 ETO05878.1 - 0.016 15.4 0.1 0.097 12.9 0.1 2.2 1 1 0 1 1 1 0 Ubiquitin-activating enzyme E1 FCCH domain TF_Zn_Ribbon PF08271.12 ETO05880.1 - 0.00033 20.1 0.5 0.00033 20.1 0.5 2.0 2 0 0 2 2 2 1 TFIIB zinc-binding DUF2616 PF11077.8 ETO05880.1 - 0.045 13.5 0.8 0.045 13.5 0.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2616) CDC45 PF02724.14 ETO05880.1 - 0.1 10.9 20.1 0.11 10.8 18.2 1.8 2 0 0 2 2 2 0 CDC45-like protein YL1 PF05764.13 ETO05880.1 - 0.13 12.4 18.7 0.027 14.6 14.8 1.9 2 0 0 2 2 2 0 YL1 nuclear protein UPF0239 PF06783.11 ETO05880.1 - 0.19 12.0 9.3 1.7 8.9 5.4 2.8 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) zf-B_box PF00643.24 ETO05880.1 - 1.1 9.5 4.3 4.1 7.6 4.3 1.9 1 1 0 1 1 1 0 B-box zinc finger zf-Sec23_Sec24 PF04810.15 ETO05880.1 - 1.2 9.2 4.8 5.2 7.2 0.2 3.1 3 0 0 3 3 3 0 Sec23/Sec24 zinc finger NOA36 PF06524.12 ETO05880.1 - 6.6 6.0 27.3 0.023 14.0 16.5 2.3 2 1 0 2 2 2 0 NOA36 protein DUF2542 PF10808.8 ETO05881.1 - 0.0014 19.1 0.0 0.0024 18.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2542) GREB1 PF15782.5 ETO05881.1 - 0.029 11.5 3.3 0.03 11.5 3.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 ETO05881.1 - 0.11 11.2 3.5 0.12 11.0 3.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Med3 PF11593.8 ETO05881.1 - 0.22 10.7 9.6 0.28 10.3 9.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CCDC53 PF10152.9 ETO05881.1 - 0.3 11.5 5.2 0.42 11.0 5.2 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Noggin PF05806.12 ETO05881.1 - 0.43 10.5 5.5 0.57 10.1 5.5 1.1 1 0 0 1 1 1 0 Noggin MRP-S31 PF15433.6 ETO05881.1 - 0.45 10.1 11.8 0.57 9.8 11.8 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S31 Presenilin PF01080.17 ETO05881.1 - 1.8 7.2 6.5 2.3 6.9 6.5 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 ETO05881.1 - 2.4 8.6 7.3 3.4 8.1 7.3 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DOR PF14839.6 ETO05881.1 - 4.4 7.2 8.5 5.7 6.8 8.5 1.1 1 0 0 1 1 1 0 DOR family Paramyxo_ncap PF00973.19 ETO05881.1 - 4.5 6.1 9.3 5.9 5.7 9.3 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein WDCP PF15390.6 ETO05883.1 - 0.21 9.9 5.6 0.22 9.8 5.6 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SEEEED PF14797.6 ETO05883.1 - 0.9 9.7 23.0 1.2 9.3 23.0 1.2 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex CDC45 PF02724.14 ETO05883.1 - 0.97 7.7 14.3 1.1 7.5 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 ETO05883.1 - 1.2 9.1 15.1 1.4 8.8 15.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NPR3 PF03666.13 ETO05883.1 - 4.5 6.0 14.3 4.9 5.8 14.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 ETO05883.1 - 4.9 6.9 13.4 5.8 6.7 13.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RRN3 PF05327.11 ETO05883.1 - 8.7 4.7 9.6 9.5 4.6 9.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETO05884.1 - 0.047 12.0 8.9 0.089 11.1 8.9 1.4 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO05884.1 - 0.65 8.1 18.4 1 7.5 18.4 1.2 1 0 0 1 1 1 0 Nop14-like family DARPP-32 PF05395.12 ETO05884.1 - 1 9.6 7.4 2.9 8.1 7.4 1.7 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 RXT2_N PF08595.11 ETO05884.1 - 1.3 9.0 15.0 3.1 7.8 15.0 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal Pes-10 PF07149.11 ETO05884.1 - 4.7 6.2 9.0 7.7 5.5 9.0 1.3 1 0 0 1 1 1 0 Pes-10 FAM176 PF14851.6 ETO05884.1 - 4.9 6.8 9.9 17 5.1 9.9 1.9 1 0 0 1 1 1 0 FAM176 family GrpE PF01025.19 ETO05885.1 - 1.3e-10 41.2 2.4 1.6e-10 40.9 2.4 1.0 1 0 0 1 1 1 1 GrpE Methyltransf_4 PF02390.17 ETO05885.1 - 0.0075 15.7 0.1 0.012 15.1 0.1 1.4 1 1 0 1 1 1 1 Putative methyltransferase PigN PF04987.14 ETO05886.1 - 0.026 13.4 1.0 0.026 13.4 1.0 2.2 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Y_phosphatase2 PF03162.13 ETO05887.1 - 3.1e-36 124.4 0.6 4.7e-36 123.9 0.6 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family DUF3439 PF11921.8 ETO05887.1 - 2.3 8.2 20.3 0.17 11.9 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) IMUP PF15761.5 ETO05887.1 - 9.5 7.0 12.3 20 5.9 12.3 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein zf-RING-like PF08746.11 ETO05890.1 - 0.15 12.4 4.6 1.8 8.9 2.4 3.2 2 1 0 2 2 2 0 RING-like domain zf-C3HC4_2 PF13923.6 ETO05890.1 - 1 9.2 6.5 8.8 6.3 3.2 3.2 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) TSC22 PF01166.18 ETO05891.1 - 0.02 15.2 0.4 0.032 14.5 0.4 1.4 1 0 0 1 1 1 0 TSC-22/dip/bun family NAD_binding_5 PF07994.12 ETO05891.1 - 0.088 12.2 1.0 0.11 11.8 1.0 1.1 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase Augurin PF15187.6 ETO05891.1 - 0.097 12.9 0.5 0.11 12.6 0.5 1.1 1 0 0 1 1 1 0 Oesophageal cancer-related gene 4 PhaP_Bmeg PF09602.10 ETO05892.1 - 0.0038 17.2 5.1 0.0038 17.2 5.1 1.7 2 0 0 2 2 2 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF2205 PF10224.9 ETO05892.1 - 0.0086 16.0 1.8 0.024 14.6 1.8 1.7 1 0 0 1 1 1 1 Short coiled-coil protein YabA PF06156.13 ETO05892.1 - 0.012 16.2 6.0 0.012 16.2 6.0 2.2 2 1 0 2 2 2 0 Initiation control protein YabA LCD1 PF09798.9 ETO05892.1 - 0.014 14.0 5.1 0.015 13.9 5.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein GIT_CC PF16559.5 ETO05892.1 - 0.047 13.6 0.4 0.047 13.6 0.4 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 ETO05892.1 - 0.058 13.7 0.7 0.058 13.7 0.7 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family Spc7 PF08317.11 ETO05892.1 - 0.077 11.9 8.7 0.047 12.6 6.5 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein SlyX PF04102.12 ETO05892.1 - 0.22 12.2 1.4 0.48 11.1 1.4 1.7 1 0 0 1 1 1 0 SlyX CENP-H PF05837.12 ETO05892.1 - 0.24 11.8 12.4 0.085 13.3 8.9 1.9 2 0 0 2 2 2 0 Centromere protein H (CENP-H) KLRAQ PF10205.9 ETO05892.1 - 0.33 11.2 8.6 1.2 9.4 8.6 2.0 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein Leu_zip PF15294.6 ETO05892.1 - 0.78 9.2 13.0 0.2 11.1 9.5 1.7 1 1 1 2 2 2 0 Leucine zipper Hid1 PF12722.7 ETO05892.1 - 1.3 7.0 7.5 1.4 6.9 7.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein UPF0242 PF06785.11 ETO05892.1 - 2.7 8.0 8.3 4.8 7.2 8.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Nup54 PF13874.6 ETO05892.1 - 3.3 7.8 8.3 5.2 7.2 6.7 1.9 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 ZapB PF06005.12 ETO05892.1 - 5.4 7.5 16.2 1.4 9.5 11.5 2.3 2 1 0 2 2 1 0 Cell division protein ZapB Syntaxin-6_N PF09177.11 ETO05892.1 - 5.5 7.6 7.2 0.49 11.0 1.1 2.3 3 0 0 3 3 3 0 Syntaxin 6, N-terminal WD40 PF00400.32 ETO05893.1 - 2.4e-52 173.7 12.8 1.6e-11 44.6 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05893.1 - 1.4e-21 76.6 3.6 0.0012 19.1 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05893.1 - 2e-09 37.2 0.7 1.6e-06 27.7 0.2 3.3 2 1 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETO05893.1 - 6.8e-09 35.9 0.6 3.4e-07 30.3 0.4 2.7 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO05893.1 - 8.6e-09 34.6 3.6 0.018 13.7 0.0 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO05893.1 - 9.7e-09 34.6 0.6 1.3 7.9 0.0 5.3 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ETO05893.1 - 0.0014 18.5 0.0 5.1 7.2 0.0 4.2 3 1 1 4 4 4 1 PQQ enzyme repeat PD40 PF07676.12 ETO05893.1 - 0.0032 17.4 1.7 19 5.3 0.0 5.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO05893.1 - 0.012 14.2 0.2 0.23 10.0 0.1 2.7 1 1 2 3 3 3 0 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO05893.1 - 0.036 12.8 0.0 1.7 7.3 0.0 2.9 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region potato_inhibit PF00280.18 ETO05893.1 - 0.11 13.2 0.1 9.8 6.9 0.0 3.2 2 1 2 4 4 4 0 Potato inhibitor I family DUF1797 PF08796.10 ETO05893.1 - 0.11 12.6 0.0 2.5 8.2 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1797) DUF3261 PF11659.8 ETO05893.1 - 0.13 12.1 0.1 13 5.6 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF3261) Phage_int_SAM_5 PF13102.6 ETO05896.1 - 0.035 14.4 0.0 0.07 13.5 0.0 1.5 1 0 0 1 1 1 0 Phage integrase SAM-like domain PH PF00169.29 ETO05896.1 - 0.08 13.5 1.1 0.6 10.6 1.0 2.2 1 1 0 1 1 1 0 PH domain WD40 PF00400.32 ETO05897.1 - 8.6e-58 191.0 20.5 4.7e-09 36.7 0.2 8.8 9 0 0 9 9 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05897.1 - 4.6e-27 94.1 3.9 0.0011 19.2 0.0 7.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO05897.1 - 1.3e-12 47.7 13.2 0.00042 19.8 0.2 5.7 3 2 2 5 5 5 3 WD40-like domain Ge1_WD40 PF16529.5 ETO05897.1 - 1.7e-10 40.4 4.9 0.0091 15.0 0.0 7.0 2 2 7 9 9 9 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO05897.1 - 3.3e-06 26.0 4.7 1.2 7.6 0.2 5.3 3 2 2 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO05897.1 - 1.4e-05 23.8 0.2 0.06 11.9 0.0 2.7 1 1 1 2 2 2 2 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO05897.1 - 1.7e-05 24.6 5.6 0.011 15.7 0.2 5.3 6 0 0 6 6 5 1 Kelch motif PD40 PF07676.12 ETO05897.1 - 4.7e-05 23.2 5.6 0.26 11.3 0.1 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO05897.1 - 7.8e-05 21.6 0.3 0.033 13.0 0.1 3.8 2 2 0 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Kelch_4 PF13418.6 ETO05897.1 - 9.1e-05 22.4 4.0 0.00011 22.1 0.1 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO05897.1 - 9.4e-05 22.6 18.0 0.027 14.7 0.4 6.9 9 0 0 9 9 7 1 Kelch motif Kelch_5 PF13854.6 ETO05897.1 - 0.00015 21.6 7.8 0.1 12.6 0.9 5.6 6 0 0 6 6 5 1 Kelch motif Kelch_1 PF01344.25 ETO05897.1 - 0.0034 16.9 3.2 0.24 11.0 0.2 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO05897.1 - 0.029 14.7 1.4 0.11 12.9 0.0 2.7 3 0 0 3 3 2 0 Galactose oxidase, central domain DUF5449 PF17528.2 ETO05897.1 - 0.04 13.7 1.7 2.8 7.7 0.1 3.8 1 1 3 4 4 4 0 Family of unknown function (DUF5449) Proteasome_A_N PF10584.9 ETO05897.1 - 0.059 13.1 4.1 12 5.7 0.0 4.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO05897.1 - 0.07 13.2 0.7 30 4.7 0.1 4.0 2 2 1 4 4 4 0 Family of unknown function (DUF5570) ACI44 PF15270.6 ETO05897.1 - 0.8 10.0 4.0 1.7 8.9 0.1 3.2 3 0 0 3 3 3 0 Metallo-carboxypeptidase inhibitor WD40 PF00400.32 ETO05898.1 - 4.7e-21 74.7 19.0 5.7e-07 30.1 1.1 6.2 5 4 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05898.1 - 1.6e-06 28.3 0.7 0.043 14.1 0.0 3.6 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05898.1 - 2.1e-06 26.7 3.4 0.0008 18.2 1.4 2.7 1 1 0 2 2 2 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO05898.1 - 0.0057 16.7 1.0 3.8 7.6 0.1 3.3 1 1 2 3 3 3 2 Ciliary BBSome complex subunit 2, middle region PSI_PsaH PF03244.14 ETO05898.1 - 0.15 11.5 0.0 0.73 9.3 0.0 1.9 2 0 0 2 2 2 0 Photosystem I reaction centre subunit VI Transket_pyr PF02779.24 ETO05899.1 - 7.8e-29 100.6 0.0 1.3e-28 99.9 0.0 1.3 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain HrcA PF01628.21 ETO05899.1 - 0.11 12.4 0.2 0.16 11.9 0.2 1.2 1 0 0 1 1 1 0 HrcA protein C terminal domain Rtt106 PF08512.12 ETO05900.1 - 0.013 15.9 0.8 0.074 13.5 0.1 2.2 2 0 0 2 2 2 0 Histone chaperone Rttp106-like PH_10 PF15411.6 ETO05900.1 - 0.4 10.9 4.8 2.9 8.2 4.8 2.4 1 1 0 1 1 1 0 Pleckstrin homology domain DUF2951 PF11166.8 ETO05900.1 - 5.3 7.3 18.0 8.9 6.6 12.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) IKI3 PF04762.12 ETO05902.1 - 0.0083 14.2 0.2 0.011 13.7 0.2 1.1 1 0 0 1 1 1 1 IKI3 family eIF2A PF08662.11 ETO05902.1 - 0.0091 15.9 0.4 0.035 14.0 0.4 1.8 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Vps16_N PF04841.13 ETO05902.1 - 0.029 13.1 0.5 0.035 12.9 0.5 1.1 1 0 0 1 1 1 0 Vps16, N-terminal region DUF733 PF05306.11 ETO05903.1 - 0.27 11.6 2.2 2.2 8.7 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF733) Kelch_6 PF13964.6 ETO05904.1 - 5.7e-07 29.6 5.4 0.0088 16.3 0.3 3.4 2 1 1 3 3 3 3 Kelch motif Kelch_1 PF01344.25 ETO05904.1 - 1.4e-06 27.8 0.9 1.4e-06 27.8 0.9 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO05904.1 - 1.8e-06 27.7 2.0 0.0015 18.5 0.2 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO05904.1 - 5.6e-05 23.3 0.1 0.00046 20.4 0.1 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO05904.1 - 0.0021 18.0 0.6 0.029 14.4 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO05904.1 - 0.0041 17.1 0.4 0.0041 17.1 0.4 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO05905.1 - 1.5e-06 27.7 6.2 1.8e-05 24.2 0.3 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO05905.1 - 1e-05 25.4 3.6 0.00039 20.4 0.0 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO05905.1 - 0.00095 19.4 1.6 0.7 10.3 0.3 4.1 3 0 0 3 3 3 1 Kelch motif PTEN_C2 PF10409.9 ETO05905.1 - 0.013 15.3 2.6 0.59 9.9 0.1 3.4 3 0 0 3 3 3 0 C2 domain of PTEN tumour-suppressor protein Kelch_2 PF07646.15 ETO05905.1 - 0.017 15.1 5.1 0.091 12.8 0.3 4.2 5 0 0 5 5 5 0 Kelch motif Spot_14 PF07084.12 ETO05905.1 - 0.032 14.4 0.4 0.08 13.1 0.4 1.7 1 0 0 1 1 1 0 Thyroid hormone-inducible hepatic protein Spot 14 N_Asn_amidohyd PF14736.6 ETO05905.1 - 0.04 13.1 0.2 0.14 11.3 0.0 1.9 1 1 1 2 2 2 0 Protein N-terminal asparagine amidohydrolase KAsynt_C_assoc PF16197.5 ETO05905.1 - 0.043 14.3 0.1 0.35 11.3 0.0 2.6 3 0 0 3 3 3 0 Ketoacyl-synthetase C-terminal extension Kelch_3 PF13415.6 ETO05905.1 - 0.049 13.9 0.2 0.6 10.5 0.0 3.1 3 0 0 3 3 3 0 Galactose oxidase, central domain BTG PF07742.12 ETO05905.1 - 0.087 12.7 0.3 10 6.0 0.0 3.0 4 0 0 4 4 4 0 BTG family AMP_N PF05195.16 ETO05906.1 - 3e-08 33.4 0.0 3.6e-08 33.2 0.0 1.2 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain WD40 PF00400.32 ETO05907.1 - 9.9e-32 108.5 23.7 1.4e-06 28.9 1.3 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05907.1 - 2.5e-12 46.9 2.6 0.15 12.4 0.1 5.5 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05907.1 - 4.4e-09 35.5 9.2 0.0074 15.0 0.0 4.6 3 2 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05907.1 - 1.3e-07 31.3 9.1 0.0008 18.8 0.3 4.3 3 1 0 3 3 3 2 WD40-like domain Rieske_2 PF13806.6 ETO05907.1 - 0.089 12.7 0.0 1.6 8.7 0.0 2.5 2 0 0 2 2 2 0 Rieske-like [2Fe-2S] domain Kelch_6 PF13964.6 ETO05908.1 - 1.3e-08 34.8 2.0 0.021 15.1 0.3 4.4 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO05908.1 - 2.3e-05 24.2 3.4 0.35 10.9 0.2 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO05908.1 - 8.7e-05 22.0 0.8 0.38 10.4 0.5 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO05908.1 - 0.00076 19.4 0.0 0.047 13.7 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO05908.1 - 0.82 9.7 3.9 24 5.1 0.0 4.0 6 0 0 6 6 6 0 Kelch motif CAP_GLY PF01302.25 ETO05911.1 - 8.8e-15 54.5 0.1 1.5e-14 53.8 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain VEFS-Box PF09733.9 ETO05911.1 - 0.013 15.3 1.4 0.028 14.2 0.3 2.1 2 0 0 2 2 2 0 VEFS-Box of polycomb protein Stork_head PF10264.9 ETO05911.1 - 0.069 13.3 0.1 0.3 11.3 0.1 2.1 1 0 0 1 1 1 0 Winged helix Storkhead-box1 domain VraX PF17412.2 ETO05912.1 - 0.055 13.1 0.5 2.1 8.1 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function PTSIIB_sorb PF03830.15 ETO05912.1 - 0.15 12.2 2.2 0.27 11.4 0.2 2.3 2 1 0 2 2 2 0 PTS system sorbose subfamily IIB component Pkinase PF00069.25 ETO05913.1 - 5.1e-11 42.4 0.2 2.8e-10 40.0 0.0 2.3 3 0 0 3 3 3 1 Protein kinase domain Mucin PF01456.17 ETO05913.1 - 0.00071 19.6 18.2 0.00071 19.6 18.2 2.5 2 0 0 2 2 2 1 Mucin-like glycoprotein Pkinase_Tyr PF07714.17 ETO05913.1 - 0.00095 18.5 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3439 PF11921.8 ETO05913.1 - 0.052 13.5 17.6 0.2 11.6 17.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TT_ORF1 PF02956.14 ETO05913.1 - 0.28 9.8 17.4 0.7 8.5 0.1 2.1 2 0 0 2 2 2 0 TT viral orf 1 Presenilin PF01080.17 ETO05913.1 - 0.32 9.7 17.6 2.4 6.8 12.0 2.2 2 0 0 2 2 2 0 Presenilin Otopetrin PF03189.13 ETO05913.1 - 5.4 5.7 8.3 2.4 6.9 2.9 2.1 2 0 0 2 2 2 0 Otopetrin CLN3 PF02487.17 ETO05913.1 - 8.9 5.2 8.0 3.8 6.5 3.2 2.2 2 0 0 2 2 2 0 CLN3 protein Phosphonate-bd PF12974.7 ETO05917.1 - 0.12 12.0 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 ABC transporter, phosphonate, periplasmic substrate-binding protein DUF4698 PF15769.5 ETO05919.1 - 0.2 10.7 11.8 0.33 9.9 11.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Macoilin PF09726.9 ETO05919.1 - 0.24 9.9 10.4 0.24 9.9 10.4 1.1 1 0 0 1 1 1 0 Macoilin family XRN_M PF17846.1 ETO05919.1 - 0.26 10.2 3.2 0.27 10.1 3.2 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Striatin PF08232.12 ETO05919.1 - 0.76 10.4 8.1 1.3 9.6 8.1 1.4 1 0 0 1 1 1 0 Striatin family DUF3807 PF12720.7 ETO05919.1 - 1.3 9.2 10.2 2 8.7 10.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) NPR3 PF03666.13 ETO05919.1 - 1.9 7.2 14.6 2.7 6.7 14.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 ETO05919.1 - 2.7 6.7 10.4 3.3 6.5 10.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO05919.1 - 5.5 5.6 11.3 7 5.3 11.3 1.1 1 0 0 1 1 1 0 Presenilin ANAPC1 PF12859.7 ETO05919.1 - 9.4 6.8 14.5 43 4.7 14.4 1.9 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 1 WD40 PF00400.32 ETO05920.1 - 1.9e-47 158.3 22.3 7.3e-10 39.3 0.2 7.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05920.1 - 1.4e-17 63.7 1.1 0.0024 18.1 0.0 6.3 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05920.1 - 7.1e-15 54.8 1.2 0.15 11.0 0.0 6.3 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO05920.1 - 0.0002 21.2 4.2 9.3 6.3 0.1 5.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO05920.1 - 0.00021 19.9 0.3 0.042 12.4 0.0 3.1 1 1 3 4 4 4 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO05920.1 - 0.0004 19.2 7.2 0.23 10.1 0.0 5.0 2 1 3 5 5 5 3 Nucleoporin Nup120/160 Kelch_2 PF07646.15 ETO05920.1 - 0.039 14.0 2.5 0.29 11.2 1.4 3.1 3 0 0 3 3 3 0 Kelch motif LRRC37AB_C PF14914.6 ETO05920.1 - 0.062 13.2 0.1 0.24 11.3 0.2 1.9 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain DUF334 PF03904.13 ETO05920.1 - 0.21 11.1 5.1 0.24 10.9 3.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF334) Kelch_1 PF01344.25 ETO05920.1 - 0.68 9.6 2.7 3.2 7.4 2.0 2.6 2 0 0 2 2 2 0 Kelch motif Ribosomal_L35Ae PF01247.18 ETO05921.1 - 0.018 15.2 0.7 0.023 14.9 0.7 1.1 1 0 0 1 1 1 0 Ribosomal protein L35Ae Imm8 PF15586.6 ETO05921.1 - 0.07 13.2 0.5 0.089 12.8 0.5 1.2 1 0 0 1 1 1 0 Immunity protein 8 FlaC_arch PF05377.11 ETO05923.1 - 5.4 7.5 10.3 6.2 7.3 0.9 4.2 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ETO05923.1 - 6.7 6.8 8.7 4.8 7.3 1.9 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) LRR_6 PF13516.6 ETO05924.1 - 1.2e-08 34.3 17.0 0.022 14.8 0.2 6.1 7 0 0 7 7 7 4 Leucine Rich repeat Menin PF05053.13 ETO05924.1 - 3.9 5.7 10.9 4.4 5.5 1.3 2.2 2 0 0 2 2 2 0 Menin RhoGAP PF00620.27 ETO05925.1 - 1.9e-15 57.0 0.0 1.9e-15 57.0 0.0 2.3 3 0 0 3 3 3 1 RhoGAP domain ANAPC2 PF08672.11 ETO05925.1 - 0.028 14.9 0.5 0.11 13.1 0.2 2.2 2 0 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 LRR_6 PF13516.6 ETO05925.1 - 0.072 13.2 0.1 24 5.3 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 ETO05925.1 - 0.38 11.2 2.4 2.9 8.4 0.7 2.7 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) Intg_mem_TP0381 PF09529.10 ETO05925.1 - 1.3 8.5 2.9 2.2 7.8 0.6 2.0 2 0 0 2 2 2 0 Integral membrane protein (intg_mem_TP0381) DUF4604 PF15377.6 ETO05925.1 - 3.1 8.2 24.7 1.7 9.1 14.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) CAP_GLY PF01302.25 ETO05928.1 - 8.7e-13 48.1 1.5 2e-12 46.9 1.5 1.6 1 0 0 1 1 1 1 CAP-Gly domain Ank_3 PF13606.6 ETO05929.1 - 0.00075 19.8 0.0 0.012 16.0 0.0 3.3 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 ETO05929.1 - 0.0024 18.1 0.0 0.0085 16.4 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HEAT PF02985.22 ETO05929.1 - 0.0053 16.9 0.0 17 6.0 0.0 4.7 3 0 0 3 3 3 0 HEAT repeat Ank PF00023.30 ETO05929.1 - 0.0079 16.6 0.0 0.15 12.6 0.0 3.1 2 0 0 2 2 2 1 Ankyrin repeat CactinC_cactus PF09732.9 ETO05929.1 - 0.024 14.6 4.7 0.044 13.7 2.3 2.8 2 0 0 2 2 2 0 Cactus-binding C-terminus of cactin protein Ank_2 PF12796.7 ETO05929.1 - 0.041 14.5 3.1 0.57 10.8 0.0 4.1 3 1 1 4 4 3 0 Ankyrin repeats (3 copies) HEAT_2 PF13646.6 ETO05929.1 - 0.043 14.2 0.0 0.16 12.4 0.0 2.0 1 0 0 1 1 1 0 HEAT repeats NLRC4_HD2 PF17776.1 ETO05929.1 - 0.049 14.2 0.1 0.049 14.2 0.1 6.4 7 1 1 8 8 8 0 NLRC4 helical domain HD2 FliG_M PF14841.6 ETO05929.1 - 0.1 12.9 0.4 18 5.6 0.0 3.3 2 0 0 2 2 2 0 FliG middle domain bVLRF1 PF18826.1 ETO05929.1 - 0.48 10.3 3.6 1.2 9.0 0.2 3.2 4 0 0 4 4 4 0 bacteroidetes VLRF1 release factor MinC_N PF05209.13 ETO05929.1 - 0.49 10.4 8.1 0.44 10.5 0.2 4.4 4 0 0 4 4 4 0 Septum formation inhibitor MinC, N-terminal domain RTP1_C1 PF10363.9 ETO05929.1 - 0.73 10.0 14.0 0.3 11.3 0.1 4.5 4 0 0 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 WD40 PF00400.32 ETO05930.1 - 7.6e-45 150.0 14.1 4.2e-08 33.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05930.1 - 4.2e-23 81.5 3.5 0.0045 17.3 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05930.1 - 1.8e-11 43.6 0.7 0.029 13.3 0.0 5.1 2 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO05930.1 - 3e-08 33.3 8.2 0.044 13.1 0.4 3.9 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO05930.1 - 3.3e-07 29.4 2.4 0.13 10.9 0.0 4.4 1 1 2 5 5 5 2 Nucleoporin Nup120/160 VID27 PF08553.10 ETO05930.1 - 1.3e-05 24.4 0.5 0.05 12.7 0.2 3.7 2 1 1 4 4 4 1 VID27 C-terminal WD40-like domain PQQ PF01011.21 ETO05930.1 - 1.5e-05 24.7 0.1 0.088 12.8 0.2 4.5 5 0 0 5 5 5 1 PQQ enzyme repeat PD40 PF07676.12 ETO05930.1 - 1.8e-05 24.5 3.4 5.1 7.2 0.0 5.9 6 1 0 6 6 6 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO05930.1 - 3.6e-05 22.5 1.4 0.073 11.6 0.4 3.1 1 1 1 3 3 3 3 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO05930.1 - 4.9e-05 23.0 0.0 0.08 12.5 0.0 2.7 1 1 1 2 2 2 2 PQQ-like domain BBS2_Mid PF14783.6 ETO05930.1 - 0.00049 20.1 1.4 2.9 8.0 0.0 4.4 4 2 0 5 5 5 1 Ciliary BBSome complex subunit 2, middle region DPPIV_N PF00930.21 ETO05930.1 - 0.00091 18.1 0.1 0.0075 15.1 0.0 2.5 2 2 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nucleoporin_N PF08801.11 ETO05930.1 - 0.0046 15.8 8.2 0.51 9.0 0.2 4.0 1 1 1 4 4 4 1 Nup133 N terminal like DUF5046 PF16465.5 ETO05930.1 - 0.021 14.3 0.0 3.6 6.9 0.0 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF5046) Utp8 PF10395.9 ETO05930.1 - 0.044 12.3 0.4 3.8 5.9 0.0 2.5 1 1 0 2 2 2 0 Utp8 family Ricin_B_lectin PF00652.22 ETO05930.1 - 0.048 13.9 0.7 0.82 9.9 0.1 2.9 1 1 0 3 3 3 0 Ricin-type beta-trefoil lectin domain Kelch_6 PF13964.6 ETO05931.1 - 1.4e-05 25.2 12.6 0.0073 16.6 0.7 4.5 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ETO05931.1 - 4.3e-05 23.3 6.0 0.024 14.6 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO05931.1 - 4.9e-05 23.2 5.7 0.092 12.8 0.1 4.2 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO05931.1 - 0.0011 18.5 8.4 0.11 12.1 0.3 4.4 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO05931.1 - 0.0068 16.4 5.4 0.016 15.2 0.8 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain WD40 PF00400.32 ETO05932.1 - 9.6e-55 181.3 11.2 1.3e-08 35.3 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05932.1 - 2.4e-26 91.8 0.6 0.00021 21.5 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05932.1 - 8.1e-16 57.9 0.3 0.00044 19.3 0.0 5.6 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO05932.1 - 1.2e-11 44.8 0.6 3.8e-05 23.7 0.0 3.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO05932.1 - 4.5e-10 38.6 0.3 3.8e-08 32.2 0.1 2.6 1 1 3 4 4 4 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO05932.1 - 2.8e-09 36.7 1.0 0.0051 16.2 0.1 3.8 1 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO05932.1 - 1.7e-08 33.6 4.9 0.46 9.1 0.0 5.0 1 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO05932.1 - 6.3e-07 29.2 2.9 6.7 6.8 0.0 7.1 7 1 1 8 8 8 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO05932.1 - 2.9e-05 24.1 0.3 0.35 11.0 0.0 3.7 2 2 1 3 3 3 1 Family of unknown function (DUF5570) Utp8 PF10395.9 ETO05932.1 - 0.0011 17.6 0.7 0.072 11.6 1.4 2.8 1 1 1 2 2 2 1 Utp8 family DUF5604 PF18300.1 ETO05932.1 - 0.0067 16.4 0.4 0.18 11.8 0.2 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF5604) DUF727 PF05303.12 ETO05932.1 - 0.011 15.8 1.2 6.3 6.9 0.0 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF727) BBS2_Mid PF14783.6 ETO05932.1 - 0.011 15.8 1.6 17 5.5 0.0 4.5 4 2 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region PQQ_2 PF13360.6 ETO05932.1 - 0.013 15.1 0.2 0.16 11.5 0.2 2.4 1 1 0 1 1 1 0 PQQ-like domain DPPIV_N PF00930.21 ETO05932.1 - 0.028 13.2 0.6 8.4 5.0 0.0 3.5 2 2 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO05932.1 - 0.032 14.2 0.0 2.7 8.1 0.1 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat nos_propeller PF18764.1 ETO05932.1 - 0.16 11.9 0.0 52 3.8 0.0 3.6 3 1 1 4 4 4 0 Nitrous oxide reductase propeller repeat Proteasome_A_N PF10584.9 ETO05932.1 - 1.7 8.4 7.4 13 5.6 0.0 4.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Ras PF00071.22 ETO05934.1 - 2.3e-08 33.8 0.4 1.2e-05 25.0 0.2 2.1 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 ETO05934.1 - 0.0014 18.6 0.2 0.0025 17.9 0.2 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ETO05934.1 - 0.008 16.4 0.1 0.017 15.4 0.0 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF3372 PF11852.8 ETO05934.1 - 0.066 12.7 0.5 0.14 11.7 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3372) WD40 PF00400.32 ETO05937.1 - 9.1e-30 102.3 4.2 1.3e-09 38.5 0.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05937.1 - 8.7e-13 48.4 0.3 0.0015 18.8 0.0 4.2 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO05937.1 - 1.3e-07 30.9 0.1 0.0019 17.3 0.0 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein RelA_SpoT PF04607.17 ETO05937.1 - 5.7e-05 23.4 1.2 0.00012 22.4 1.2 1.5 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins PD40 PF07676.12 ETO05937.1 - 6.3e-05 22.8 0.3 9.9 6.2 0.0 4.4 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO05937.1 - 0.0015 18.0 1.0 0.011 15.0 0.3 2.5 1 1 1 2 2 2 1 WD40-like domain Nbas_N PF15492.6 ETO05937.1 - 0.0025 17.2 0.1 6.7 5.9 0.0 3.2 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO05937.1 - 0.0029 16.3 0.2 0.23 10.1 0.0 2.8 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Mid2 PF04478.12 ETO05937.1 - 0.0096 15.8 0.4 1.4 8.7 0.1 2.5 1 1 1 2 2 2 1 Mid2 like cell wall stress sensor DUF4790 PF16037.5 ETO05938.1 - 0.036 14.5 1.0 0.036 14.5 1.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4790) DUF3824 PF12868.7 ETO05938.1 - 0.45 11.2 2.5 1.2 9.8 0.0 2.4 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) DUF2407_C PF13373.6 ETO05938.1 - 0.48 10.6 5.4 0.54 10.4 0.0 2.8 2 1 0 2 2 2 0 DUF2407 C-terminal domain UPF0242 PF06785.11 ETO05938.1 - 0.75 9.9 22.0 90 3.1 22.0 2.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 ETO05938.1 - 1.7 7.9 9.7 3.6 6.8 9.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) LMBR1 PF04791.16 ETO05938.1 - 2.4 6.9 6.9 3.1 6.6 6.9 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 ETO05938.1 - 3.2 7.0 8.8 5.4 6.3 8.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) V_ATPase_I PF01496.19 ETO05938.1 - 3.9 5.3 9.4 6.1 4.6 9.4 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Orf78 PF06024.12 ETO05939.1 - 0.0074 16.6 0.3 0.05 13.9 0.0 2.2 2 0 0 2 2 2 1 Orf78 (ac78) PspB PF06667.12 ETO05939.1 - 5.4 7.2 6.8 0.99 9.5 0.1 2.6 3 0 0 3 3 3 0 Phage shock protein B Actin PF00022.19 ETO05940.1 - 0.0059 15.3 0.0 0.007 15.0 0.0 1.1 1 0 0 1 1 1 1 Actin SPRY PF00622.28 ETO05941.1 - 2.1e-06 27.8 0.1 4.6e-06 26.7 0.1 1.7 1 0 0 1 1 1 1 SPRY domain SAM_2 PF07647.17 ETO05941.1 - 0.014 15.5 0.3 0.16 12.1 0.1 2.7 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) MotCF PF09158.10 ETO05942.1 - 0.19 11.8 8.6 1.6 8.8 0.4 2.5 2 0 0 2 2 2 0 Bacteriophage T4 MotA, C-terminal WD40 PF00400.32 ETO05943.1 - 7.7e-40 134.2 17.8 7.7e-07 29.7 0.8 7.3 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05943.1 - 3.8e-12 46.4 0.3 0.0049 17.1 0.0 5.3 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05943.1 - 1.8e-08 33.5 2.4 0.017 13.8 0.1 5.2 1 1 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO05943.1 - 2.2e-05 24.0 7.1 0.23 10.8 0.0 5.3 3 2 0 5 5 5 3 WD40-like domain Rieske_2 PF13806.6 ETO05943.1 - 0.15 12.0 0.0 9.7 6.2 0.0 2.9 3 0 0 3 3 3 0 Rieske-like [2Fe-2S] domain Peptidase_C14 PF00656.22 ETO05944.1 - 1.5e-13 51.3 0.7 4.5e-13 49.7 0.7 1.8 1 0 0 1 1 1 1 Caspase domain Kelch_1 PF01344.25 ETO05944.1 - 2.3e-05 23.9 1.3 0.028 14.0 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO05944.1 - 0.00052 19.9 4.6 0.54 10.3 0.2 4.6 5 0 0 5 5 5 2 Kelch motif Caleosin PF05042.13 ETO05944.1 - 0.034 14.1 0.0 4.1 7.3 0.0 2.6 2 0 0 2 2 2 0 Caleosin related protein Kelch_6 PF13964.6 ETO05944.1 - 0.47 10.8 5.7 33 4.9 0.2 5.0 6 0 0 6 6 6 0 Kelch motif CAP_GLY PF01302.25 ETO05945.1 - 9.2e-278 896.9 106.3 2.6e-17 62.6 0.8 21.9 21 1 0 21 21 21 21 CAP-Gly domain NifZ PF04319.13 ETO05945.1 - 0.2 11.5 8.8 1.3 8.9 0.0 6.4 5 0 0 5 5 5 0 NifZ domain BSP_II PF05432.11 ETO05945.1 - 0.69 9.6 29.4 3.8 7.1 8.2 2.9 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) YfzA PF14118.6 ETO05945.1 - 1.1 9.8 2.7 3e+02 1.9 0.0 5.8 9 0 0 9 9 9 0 YfzA-like protein DUF913 PF06025.12 ETO05945.1 - 3.8 6.4 7.9 6.4 5.6 0.3 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) CAP_GLY PF01302.25 ETO05946.1 - 2.6e-83 274.0 23.9 2.1e-20 72.5 0.4 6.5 6 0 0 6 6 6 6 CAP-Gly domain EF-hand_6 PF13405.6 ETO05946.1 - 7.4e-06 25.5 6.1 0.026 14.5 0.0 3.6 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 ETO05946.1 - 1.7e-05 24.6 1.5 0.016 15.0 0.1 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO05946.1 - 0.0004 19.7 10.2 0.0065 15.9 0.0 3.8 5 0 0 5 5 5 2 EF hand EF-hand_7 PF13499.6 ETO05946.1 - 0.00096 19.6 9.3 0.0035 17.8 4.2 3.3 3 1 2 5 5 5 3 EF-hand domain pair DnaJ_CXXCXGXG PF00684.19 ETO05946.1 - 0.0023 18.2 2.2 0.0051 17.1 2.2 1.5 1 0 0 1 1 1 1 DnaJ central domain EF-hand_5 PF13202.6 ETO05946.1 - 0.015 14.8 5.8 0.44 10.1 0.1 3.1 3 0 0 3 3 3 0 EF hand Lar_N PF09861.9 ETO05946.1 - 0.054 12.7 0.0 0.093 11.9 0.0 1.3 1 0 0 1 1 1 0 Lactate racemase N-terminal domain ZZ PF00569.17 ETO05946.1 - 0.16 11.8 3.6 0.38 10.6 3.6 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type OAD_gamma PF04277.13 ETO05946.1 - 0.36 11.4 2.4 2.9 8.6 0.0 3.0 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain zinc_ribbon_10 PF10058.9 ETO05946.1 - 1.2 9.0 4.0 0.4 10.4 0.6 2.0 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein JmjN PF02375.17 ETO05946.1 - 1.9 8.6 3.8 33 4.6 0.6 3.8 4 0 0 4 4 4 0 jmjN domain Baculo_11_kDa PF06143.11 ETO05946.1 - 2.3 7.9 4.6 2 8.0 1.5 2.4 3 0 0 3 3 3 0 Baculovirus 11 kDa family RRM_7 PF16367.5 ETO05947.1 - 0.032 14.4 2.4 0.037 14.1 0.0 2.2 2 1 1 3 3 3 0 RNA recognition motif RRM_1 PF00076.22 ETO05947.1 - 0.049 13.5 0.1 0.049 13.5 0.1 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ALMT PF11744.8 ETO05947.1 - 0.053 12.3 5.5 0.058 12.2 5.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO05947.1 - 0.069 11.9 8.2 0.068 11.9 8.2 1.2 1 0 0 1 1 1 0 Presenilin Suf PF05843.14 ETO05947.1 - 0.12 12.3 6.9 0.14 12.1 6.9 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Raftlin PF15250.6 ETO05947.1 - 0.12 11.0 8.3 0.14 10.9 8.3 1.0 1 0 0 1 1 1 0 Raftlin DUF913 PF06025.12 ETO05947.1 - 0.22 10.4 4.4 0.3 10.0 4.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 ETO05947.1 - 0.93 9.5 14.7 1.1 9.2 14.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 ETO05947.1 - 3 6.6 15.1 3.6 6.3 15.1 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 ETO05947.1 - 5.7 5.8 14.8 6.4 5.7 14.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SOBP PF15279.6 ETO05947.1 - 6.1 7.4 8.9 7.2 7.1 8.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Hid1 PF12722.7 ETO05947.1 - 6.6 4.7 11.6 7.7 4.5 11.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SRP-alpha_N PF04086.13 ETO05947.1 - 9.8 6.0 23.0 12 5.7 23.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal PDR_CDR PF06422.12 ETO05950.1 - 0.043 13.7 0.0 11 6.0 0.0 2.4 2 0 0 2 2 2 0 CDR ABC transporter RRM_1 PF00076.22 ETO05952.1 - 0.00011 21.9 0.2 0.00029 20.6 0.2 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C2H2_jaz PF12171.8 ETO05952.1 - 0.0069 16.7 0.3 0.0069 16.7 0.3 4.3 4 1 0 4 4 4 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETO05952.1 - 2.7 8.5 15.9 0.6 10.6 1.1 4.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type UL45 PF05473.12 ETO05953.1 - 0.054 13.1 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like LAP1C PF05609.12 ETO05953.1 - 0.29 10.2 15.1 0.47 9.5 15.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hid1 PF12722.7 ETO05953.1 - 0.72 7.9 10.3 1.3 7.1 10.3 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Shisa PF13908.6 ETO05953.1 - 2 8.6 8.4 0.36 11.1 4.4 1.7 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Kinesin PF00225.23 ETO05955.1 - 2.3e-12 46.5 6.3 8.9e-12 44.6 0.1 2.0 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ETO05955.1 - 4.1e-10 39.8 0.6 4.1e-10 39.8 0.6 2.0 1 1 1 2 2 2 1 Microtubule binding DUF3472 PF11958.8 ETO05956.1 - 0.068 13.6 0.7 0.09 13.2 0.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3472) CDC45 PF02724.14 ETO05958.1 - 0.2 9.9 9.7 0.27 9.5 9.7 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO05958.1 - 0.56 10.0 10.0 0.89 9.3 10.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Urb2 PF10441.9 ETO05959.1 - 0.0017 18.3 2.0 0.021 14.8 0.0 3.5 3 1 0 3 3 3 1 Urb2/Npa2 family Plasmid_parti PF01672.16 ETO05959.1 - 0.02 15.5 1.0 0.23 12.1 0.1 3.3 2 0 0 2 2 2 0 Putative plasmid partition protein DUF3583 PF12126.8 ETO05959.1 - 0.047 13.1 1.5 0.11 11.9 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) COG5 PF10392.9 ETO05959.1 - 5.3 7.2 7.8 4.8 7.4 2.8 2.9 2 0 0 2 2 2 0 Golgi transport complex subunit 5 RGS PF00615.19 ETO05960.1 - 4.1e-25 88.3 4.1 8.5e-25 87.3 4.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain cNMP_binding PF00027.29 ETO05960.1 - 0.15 12.2 0.0 0.4 10.8 0.0 1.7 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain adh_short PF00106.25 ETO05961.1 - 3.6e-41 140.8 0.2 4.9e-40 137.1 0.2 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO05961.1 - 3.5e-24 85.7 0.1 1.1e-10 41.5 0.0 2.7 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO05961.1 - 5.1e-06 26.5 0.0 2.4e-05 24.3 0.0 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ETO05961.1 - 0.0017 17.9 0.0 0.0086 15.6 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ETO05961.1 - 0.0023 17.8 0.0 0.0066 16.4 0.0 1.7 2 0 0 2 2 2 1 NAD(P)H-binding NmrA PF05368.13 ETO05961.1 - 0.062 12.8 0.0 0.15 11.6 0.0 1.6 2 0 0 2 2 2 0 NmrA-like family Peptidase_S9_N PF02897.15 ETO05962.1 - 4.3e-96 322.2 2.0 5.7e-96 321.8 2.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Peptidase_S9 PF00326.21 ETO05963.1 - 1.2e-59 201.3 0.0 1.4e-59 201.1 0.0 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase family Hydrolase_4 PF12146.8 ETO05963.1 - 0.017 14.4 0.0 0.027 13.7 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Esterase PF00756.20 ETO05963.1 - 0.11 12.2 0.0 0.13 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative esterase Beta-lactamase PF00144.24 ETO05964.1 - 2.8e-21 76.1 0.2 6.6e-12 45.3 0.0 2.9 2 1 0 2 2 2 2 Beta-lactamase Biopterin_H PF00351.21 ETO05966.1 - 1.3e-129 432.0 0.1 1.6e-129 431.7 0.1 1.1 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase WD40 PF00400.32 ETO05967.1 - 1.4e-36 123.8 17.5 7.5e-07 29.8 0.5 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05967.1 - 4.7e-15 55.7 0.6 0.00015 22.0 0.0 5.4 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO05967.1 - 6.9e-11 41.5 10.7 0.014 14.1 0.0 5.8 1 1 4 5 5 5 5 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO05967.1 - 0.0087 16.1 6.0 8.5 6.5 0.1 5.6 1 1 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO05968.1 - 9.3e-30 102.2 29.8 1e-05 26.2 0.1 7.3 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO05968.1 - 8e-08 32.5 3.9 0.68 10.3 0.0 5.7 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Alg6_Alg8 PF03155.15 ETO05969.1 - 1.2e-68 232.3 24.5 3e-66 224.4 24.5 2.0 1 1 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family DUF4131 PF13567.6 ETO05969.1 - 0.048 13.3 0.7 0.048 13.3 0.7 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) DUF4160 PF13711.6 ETO05970.1 - 0.056 13.8 0.5 0.16 12.4 0.1 1.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4160) DUF2052 PF09747.9 ETO05973.1 - 0.0027 17.9 2.4 0.0031 17.7 2.4 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) CelD_N PF02927.14 ETO05973.1 - 0.079 13.9 0.8 0.17 12.8 0.1 1.8 2 0 0 2 2 2 0 Cellulase N-terminal ig-like domain Serinc PF03348.15 ETO05973.1 - 0.079 11.9 0.6 0.085 11.8 0.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3671 PF12420.8 ETO05976.1 - 0.0034 17.4 0.6 0.007 16.4 0.6 1.6 1 1 0 1 1 1 1 Protein of unknown function KdpA PF03814.15 ETO05976.1 - 0.027 12.7 0.5 0.029 12.6 0.5 1.2 1 0 0 1 1 1 0 Potassium-transporting ATPase A subunit Ferlin_C PF16165.5 ETO05976.1 - 0.046 13.7 0.1 0.097 12.6 0.0 1.6 2 0 0 2 2 2 0 Ferlin C-terminus m_DGTX_Dc1a_b_c PF17491.2 ETO05977.1 - 0.044 14.4 2.2 0.12 13.0 2.2 1.8 1 0 0 1 1 1 0 Spider Toxins mu-diguetoxin-1 a, b and c B56 PF01603.20 ETO05978.1 - 9.1e-50 169.8 0.4 1.1e-49 169.6 0.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RB_A PF01858.17 ETO05978.1 - 0.042 13.7 0.4 0.04 13.7 0.4 1.2 1 0 0 1 1 1 0 Retinoblastoma-associated protein A domain CLIP_SPH_Scar PF18399.1 ETO05978.1 - 0.13 12.4 0.2 0.33 11.1 0.0 1.7 2 0 0 2 2 2 0 Clip-domain serine protease homolog Scarface ABC_tran PF00005.27 ETO05980.1 - 7.7e-05 23.2 0.0 0.00022 21.7 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 ETO05980.1 - 0.00012 22.0 0.0 0.0003 20.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO05980.1 - 0.00016 21.3 0.0 0.00033 20.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETO05980.1 - 0.00032 20.6 0.1 0.00077 19.4 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ETO05980.1 - 0.00069 20.0 0.0 0.0019 18.6 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain TsaE PF02367.17 ETO05980.1 - 0.00095 19.2 0.1 0.0043 17.1 0.0 2.0 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ETO05980.1 - 0.0017 18.8 0.3 0.0053 17.2 0.1 1.9 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activ_2 PF14532.6 ETO05980.1 - 0.002 18.3 0.3 0.069 13.3 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 ETO05980.1 - 0.0034 17.7 0.1 0.019 15.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ETO05980.1 - 0.0075 16.0 0.1 0.14 11.9 0.0 2.4 2 0 0 2 2 2 1 IstB-like ATP binding protein DUF815 PF05673.13 ETO05980.1 - 0.0096 15.1 0.1 0.02 14.0 0.0 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_8 PF12780.7 ETO05980.1 - 0.011 15.1 0.2 0.028 13.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 Sigma54_activat PF00158.26 ETO05980.1 - 0.012 15.4 0.1 0.07 12.8 0.0 2.2 3 0 0 3 3 3 0 Sigma-54 interaction domain PduV-EutP PF10662.9 ETO05980.1 - 0.012 15.4 0.1 0.021 14.6 0.1 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 ETO05980.1 - 0.013 14.6 0.0 0.029 13.5 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain T2SSE PF00437.20 ETO05980.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein Rad17 PF03215.15 ETO05980.1 - 0.038 13.9 0.0 0.073 13.0 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_19 PF13245.6 ETO05980.1 - 0.068 13.5 0.2 0.27 11.5 0.1 1.9 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ETO05980.1 - 0.073 13.0 2.4 0.15 12.0 0.1 2.5 2 1 0 2 2 2 0 NACHT domain Zeta_toxin PF06414.12 ETO05980.1 - 0.14 11.4 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_23 PF13476.6 ETO05980.1 - 0.16 12.5 0.1 0.16 12.5 0.1 2.4 2 1 0 2 2 2 0 AAA domain SAM_1 PF00536.30 ETO05981.1 - 0.076 13.5 0.1 0.17 12.3 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF3437 PF11919.8 ETO05983.1 - 0.11 12.4 0.5 0.4 10.6 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) GREB1 PF15782.5 ETO05983.1 - 0.56 7.3 15.5 0.84 6.7 15.5 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 ETO05983.1 - 1.9 6.7 31.3 0.16 10.3 0.7 2.3 2 0 0 2 2 2 0 CDC45-like protein SOBP PF15279.6 ETO05983.1 - 4.3 7.9 12.4 7.5 7.1 12.4 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4611 PF15387.6 ETO05983.1 - 8.8 6.6 31.1 0.36 11.1 1.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) HhH-GPD PF00730.25 ETO05985.1 - 0.0049 17.3 0.1 2.2 8.8 0.0 3.9 4 0 0 4 4 4 1 HhH-GPD superfamily base excision DNA repair protein DUF1318 PF07027.12 ETO05985.1 - 0.011 16.1 0.1 0.043 14.3 0.1 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1318) CPSase_L_D3 PF02787.19 ETO05985.1 - 0.19 12.0 2.7 2.6 8.4 0.9 2.7 2 0 0 2 2 2 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain DUF2203 PF09969.9 ETO05985.1 - 0.4 11.4 3.4 1.1 9.9 0.1 2.8 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Imm6 PF14434.6 ETO05985.1 - 0.5 10.3 7.3 17 5.4 0.1 3.6 3 0 0 3 3 3 0 Immunity protein Imm6 PglZ PF08665.12 ETO05985.1 - 2.1 8.4 5.1 1.7 8.7 2.4 2.1 1 1 1 2 2 2 0 PglZ domain Saf_2TM PF18303.1 ETO05986.1 - 0.039 13.5 4.6 0.046 13.3 0.3 2.2 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain HTH_Mga PF08280.11 ETO05986.1 - 0.052 13.6 0.9 0.55 10.3 0.7 2.3 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain DHHC PF01529.20 ETO05986.1 - 2.7 8.1 14.8 0.67 10.1 11.3 1.8 2 0 0 2 2 2 0 DHHC palmitoyltransferase RVT_1 PF00078.27 ETO05987.1 - 1.6e-22 80.1 0.0 2.6e-22 79.4 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) MFAP1 PF06991.11 ETO05988.1 - 0.016 15.0 3.6 0.028 14.2 3.6 1.3 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing ubiquitin PF00240.23 ETO05989.1 - 0.0039 16.9 0.0 0.0079 15.9 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family EF-hand_6 PF13405.6 ETO05989.1 - 0.023 14.6 0.7 0.21 11.6 0.0 2.8 2 0 0 2 2 2 0 EF-hand domain CAP_GLY PF01302.25 ETO05990.1 - 6.1e-09 35.8 0.0 8.9e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Pkinase PF00069.25 ETO05991.1 - 7e-11 42.0 0.4 2.9e-10 40.0 0.1 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO05991.1 - 7e-11 41.9 0.1 2.3e-10 40.2 0.1 1.9 1 0 0 1 1 1 1 Protein tyrosine kinase UN_NPL4 PF11543.8 ETO05991.1 - 0.034 14.6 1.1 0.11 13.0 0.4 2.3 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 HEAT PF02985.22 ETO05992.1 - 3.7e-07 29.8 2.1 0.049 13.9 0.0 4.1 3 0 0 3 3 3 3 HEAT repeat HEAT_2 PF13646.6 ETO05992.1 - 0.067 13.6 0.0 56 4.2 0.0 3.3 3 0 0 3 3 3 0 HEAT repeats Pkinase_Tyr PF07714.17 ETO05993.1 - 2.7e-26 92.4 0.0 3.4e-26 92.1 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO05993.1 - 5.3e-21 75.2 0.0 7.9e-21 74.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain SAM_2 PF07647.17 ETO05995.1 - 0.0006 19.9 0.1 0.0012 18.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF1682 PF07946.14 ETO05995.1 - 0.0022 17.3 7.4 0.003 16.8 7.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) SAM_1 PF00536.30 ETO05995.1 - 0.0032 17.9 0.1 0.016 15.6 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF4200 PF13863.6 ETO05995.1 - 0.0099 16.3 15.4 0.021 15.2 15.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) Carboxyl_trans PF01039.22 ETO05995.1 - 0.011 14.4 0.0 0.016 13.8 0.0 1.2 1 0 0 1 1 1 0 Carboxyl transferase domain NCD1 PF04904.13 ETO05995.1 - 0.14 12.1 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 NAB conserved region 1 (NCD1) RFC1 PF08519.12 ETO05996.1 - 1.1e-41 142.6 0.0 2.8e-41 141.3 0.0 1.6 2 0 0 2 2 2 1 Replication factor RFC1 C terminal domain RNA_pol_Rpc4 PF05132.14 ETO05996.1 - 0.096 13.1 5.9 0.16 12.4 5.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 ETO05996.1 - 0.59 9.9 7.5 0.84 9.4 7.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YL1 PF05764.13 ETO05996.1 - 1 9.4 15.8 1.5 8.8 15.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein AAA PF00004.29 ETO05997.1 - 3.7e-11 43.6 0.2 2.4e-10 40.9 0.1 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ETO05997.1 - 1.7e-06 28.1 0.0 4.3e-06 26.8 0.0 1.7 1 0 0 1 1 1 1 Rad17 P-loop domain BRCT PF00533.26 ETO05997.1 - 2.7e-05 24.5 0.6 0.0013 19.0 0.1 3.4 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain RuvB_N PF05496.12 ETO05997.1 - 0.00034 20.4 0.0 0.00069 19.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETO05997.1 - 0.017 15.4 0.0 0.056 13.7 0.0 1.9 1 1 0 1 1 1 0 AAA domain AAA_19 PF13245.6 ETO05997.1 - 0.017 15.4 0.2 9 6.6 0.1 2.6 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETO05997.1 - 0.021 14.6 0.0 0.041 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO05997.1 - 0.026 14.9 0.0 0.082 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 ETO05997.1 - 0.026 14.5 0.0 0.13 12.3 0.0 2.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO05997.1 - 0.056 13.8 0.8 0.33 11.4 0.0 2.8 2 1 0 2 2 2 0 RNA helicase AAA_assoc_2 PF16193.5 ETO05997.1 - 0.074 13.4 0.0 0.41 11.0 0.0 2.4 1 0 0 1 1 1 0 AAA C-terminal domain AAA_18 PF13238.6 ETO05997.1 - 0.49 10.9 0.1 0.49 10.9 0.1 2.5 3 0 0 3 3 2 0 AAA domain CDC27 PF09507.10 ETO05997.1 - 5.7 6.2 44.7 0.13 11.6 36.1 2.3 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 Herpes_pp85 PF04637.12 ETO05998.1 - 0.74 8.2 6.0 1 7.7 6.0 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) IMUP PF15761.5 ETO05998.1 - 0.92 10.2 11.6 0.39 11.4 8.1 2.1 2 0 0 2 2 2 0 Immortalisation up-regulated protein SR-25 PF10500.9 ETO05998.1 - 2.5 7.6 24.0 0.022 14.4 15.7 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Mus7 PF09462.10 ETO05999.1 - 0.021 13.7 0.3 0.025 13.5 0.3 1.0 1 0 0 1 1 1 0 Mus7/MMS22 family ALIX_LYPXL_bnd PF13949.6 ETO05999.1 - 0.022 14.1 1.1 0.026 13.8 1.1 1.0 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV TyeA PF09059.10 ETO06002.1 - 0.015 15.4 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 TyeA Kelch_6 PF13964.6 ETO06003.1 - 6.6e-10 38.9 1.5 0.01 16.1 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO06003.1 - 0.00012 21.5 3.4 3.8 7.2 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO06003.1 - 0.004 17.4 0.2 0.59 10.5 0.0 3.4 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO06003.1 - 0.0048 16.9 0.3 0.44 10.6 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO06003.1 - 0.0063 15.7 0.6 2.5 7.2 0.0 2.2 2 0 0 2 2 2 2 Protein N-terminal asparagine amidohydrolase Nbs1_C PF08599.10 ETO06003.1 - 0.02 15.0 0.9 0.087 13.0 0.3 2.2 2 0 0 2 2 2 0 DNA damage repair protein Nbs1 Kelch_5 PF13854.6 ETO06003.1 - 0.68 10.0 5.4 34 4.6 0.0 4.7 6 0 0 6 6 6 0 Kelch motif WD40 PF00400.32 ETO06004.1 - 2.6e-64 211.6 12.9 2.1e-10 41.0 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06004.1 - 1.8e-22 79.4 1.8 0.00029 21.1 0.0 6.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06004.1 - 3.6e-17 62.3 0.5 0.0019 17.2 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06004.1 - 1.1e-09 37.5 6.2 0.013 14.2 0.1 5.3 1 1 5 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06004.1 - 1.6e-07 30.9 5.7 0.025 13.9 0.2 3.8 1 1 3 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO06004.1 - 2.3e-05 23.1 0.5 0.44 9.0 0.0 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO06004.1 - 3e-05 23.8 3.0 5.4 7.1 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO06004.1 - 0.00013 20.8 3.0 0.62 8.7 0.0 4.2 1 1 4 5 5 5 2 Nup133 N terminal like DUF5570 PF17731.1 ETO06004.1 - 0.0012 18.9 0.7 11 6.1 0.0 3.8 1 1 3 4 4 4 0 Family of unknown function (DUF5570) PQQ PF01011.21 ETO06004.1 - 0.0016 18.3 0.0 4.2 7.5 0.0 4.5 4 0 0 4 4 4 1 PQQ enzyme repeat Coatomer_WDAD PF04053.14 ETO06004.1 - 0.0031 16.6 2.4 0.22 10.5 0.1 2.9 1 1 2 3 3 3 1 Coatomer WD associated region DUF5046 PF16465.5 ETO06004.1 - 0.0043 16.5 0.0 0.18 11.2 0.0 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) Proteasome_A_N PF10584.9 ETO06004.1 - 0.0061 16.2 3.4 6.5 6.5 0.0 4.5 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETO06004.1 - 0.035 13.7 0.1 0.79 9.2 0.0 2.7 1 1 1 2 2 2 0 PQQ-like domain Resistin PF06954.11 ETO06004.1 - 0.067 13.7 0.0 1.8e+02 2.7 0.0 3.8 2 1 1 4 4 4 0 Resistin Phage_CI_repr PF07022.13 ETO06004.1 - 0.14 12.2 0.2 56 3.9 0.0 3.1 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain Zincin_2 PF10103.9 ETO06004.1 - 0.21 10.8 0.0 0.86 8.8 0.0 1.9 2 0 0 2 2 2 0 Zincin-like metallopeptidase MCM PF00493.23 ETO06006.1 - 1.6e-40 138.6 3.6 4.7e-30 104.4 0.0 2.9 3 0 0 3 3 3 2 MCM P-loop domain MCM_lid PF17855.1 ETO06006.1 - 3.3e-25 88.3 5.3 6.9e-25 87.3 5.3 1.6 1 0 0 1 1 1 1 MCM AAA-lid domain MCM6_C PF18263.1 ETO06006.1 - 8.3e-11 42.1 4.5 3.2e-10 40.2 4.5 2.1 1 0 0 1 1 1 1 MCM6 C-terminal winged-helix domain Mg_chelatase PF01078.21 ETO06006.1 - 5.9e-05 22.5 0.0 0.0014 18.1 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETO06006.1 - 0.0024 17.7 0.0 0.0053 16.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF3396 PF11876.8 ETO06006.1 - 0.038 13.5 0.1 0.077 12.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3396) Mg_chelatase_C PF13335.6 ETO06006.1 - 0.057 14.0 2.8 0.25 12.0 1.7 2.5 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI C-terminal DUF755 PF05501.11 ETO06009.1 - 0.11 12.7 6.2 0.92 9.8 5.9 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF755) PCRF PF03462.18 ETO06009.1 - 3.2 7.6 7.7 0.82 9.5 1.5 2.7 1 1 1 2 2 2 0 PCRF domain NPV_P10 PF05531.12 ETO06009.1 - 8 7.0 6.4 42 4.7 0.2 3.6 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AMH_N PF04709.12 ETO06011.1 - 0.12 11.3 0.0 0.15 10.9 0.0 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region MscS_TM PF12794.7 ETO06013.1 - 0.0026 16.7 1.2 0.0046 15.9 1.2 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 DUF913 PF06025.12 ETO06013.1 - 0.017 14.1 0.6 0.019 14.0 0.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RP-C_C PF11800.8 ETO06013.1 - 0.038 14.1 1.6 0.043 13.9 1.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DDHD PF02862.17 ETO06013.1 - 0.049 13.8 1.9 0.052 13.7 1.9 1.2 1 0 0 1 1 1 0 DDHD domain Bac_export_2 PF01312.19 ETO06013.1 - 0.057 12.6 5.8 0.084 12.1 5.8 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family NARP1 PF12569.8 ETO06013.1 - 0.058 12.3 6.5 0.068 12.1 6.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RR_TM4-6 PF06459.12 ETO06013.1 - 0.092 12.6 9.9 0.11 12.3 9.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RXT2_N PF08595.11 ETO06013.1 - 0.12 12.4 9.4 0.17 11.9 9.4 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal VIT1 PF01988.19 ETO06013.1 - 0.17 11.8 0.3 0.24 11.2 0.3 1.2 1 0 0 1 1 1 0 VIT family Paf1 PF03985.13 ETO06013.1 - 0.64 9.0 13.6 0.74 8.8 13.6 1.1 1 0 0 1 1 1 0 Paf1 V_ATPase_I PF01496.19 ETO06013.1 - 0.89 7.4 6.5 1.1 7.1 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 ETO06013.1 - 1 9.3 3.2 1.3 9.0 3.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO06013.1 - 1.7 7.3 6.7 2 7.1 6.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 ETO06013.1 - 2 7.8 10.6 2.4 7.5 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Vfa1 PF08432.10 ETO06013.1 - 4.5 7.6 12.8 5.9 7.2 12.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CAP_GLY PF01302.25 ETO06016.1 - 8.3e-14 51.4 0.6 0.0014 18.6 0.0 3.3 2 1 1 3 3 3 3 CAP-Gly domain DUF2286 PF10051.9 ETO06016.1 - 0.056 13.2 0.0 0.088 12.6 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2286) AAA_22 PF13401.6 ETO06020.1 - 0.0028 18.0 0.1 0.012 15.9 0.1 2.2 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO06020.1 - 0.11 12.2 0.1 0.32 10.7 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO06020.1 - 0.13 12.6 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain WD40 PF00400.32 ETO06021.1 - 7.8e-62 203.8 16.0 5.9e-10 39.6 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06021.1 - 2.2e-15 56.7 1.1 0.0042 17.4 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06021.1 - 5.1e-12 45.4 0.0 0.0019 17.2 0.0 4.9 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO06021.1 - 1.3e-10 41.5 0.7 0.00012 22.0 0.1 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO06021.1 - 1.3e-06 28.0 0.8 0.0048 16.3 0.1 2.1 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO06021.1 - 3.3e-05 23.7 0.1 9.4 6.3 0.1 5.0 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO06021.1 - 0.0028 17.3 0.1 2.5 7.8 0.0 4.3 4 1 1 5 5 5 1 HepA-related protein (HARP) Mid2 PF04478.12 ETO06021.1 - 0.037 13.9 0.7 0.36 10.7 0.0 2.8 2 2 2 4 4 4 0 Mid2 like cell wall stress sensor Nup160 PF11715.8 ETO06021.1 - 0.05 12.3 6.1 8 5.0 0.0 4.3 1 1 3 5 5 5 0 Nucleoporin Nup120/160 DUF3902 PF13042.6 ETO06021.1 - 0.055 13.0 0.3 0.11 12.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) Proteasome_A_N PF10584.9 ETO06021.1 - 0.16 11.7 7.1 8.3 6.2 0.0 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature RabGAP-TBC PF00566.18 ETO06021.1 - 0.98 9.0 4.0 44 3.6 0.2 3.8 4 1 0 5 5 5 0 Rab-GTPase-TBC domain DUF4451 PF14616.6 ETO06022.1 - 0.06 13.6 5.4 0.78 10.0 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4451) zf-like PF04071.12 ETO06022.1 - 0.069 13.1 0.8 0.069 13.1 0.8 2.1 1 1 1 2 2 2 0 Cysteine-rich small domain Iwr1 PF08574.10 ETO06022.1 - 0.08 14.0 0.7 0.08 14.0 0.7 1.5 2 0 0 2 2 2 0 Transcription factor Iwr1 eIF3_N PF09440.10 ETO06022.1 - 0.5 10.8 5.9 0.59 10.6 5.1 1.5 1 1 1 2 2 2 0 eIF3 subunit 6 N terminal domain PHD_4 PF16866.5 ETO06022.1 - 1.4 9.0 8.3 6.1 7.0 6.6 2.3 1 1 1 2 2 2 0 PHD-finger zinc_ribbon_15 PF17032.5 ETO06022.1 - 2.8 8.8 10.3 4.7 8.0 10.3 1.5 1 1 0 1 1 1 0 zinc-ribbon family ATE_C PF04377.15 ETO06023.1 - 0.15 12.6 3.1 0.83 10.3 0.3 2.7 1 1 2 3 3 3 0 Arginine-tRNA-protein transferase, C terminus Rhabdo_glycop PF00974.18 ETO06024.1 - 0.058 11.8 0.2 0.087 11.3 0.2 1.2 1 0 0 1 1 1 0 Rhabdovirus spike glycoprotein PIN_9 PF18477.1 ETO06024.1 - 0.078 13.3 0.5 0.19 12.1 0.5 1.7 1 0 0 1 1 1 0 PIN like domain Peptidase_C14 PF00656.22 ETO06025.1 - 0.032 14.2 0.9 0.067 13.1 0.4 1.7 2 0 0 2 2 2 0 Caspase domain Neuraminidase PF18413.1 ETO06025.1 - 0.074 12.7 0.0 0.12 12.1 0.0 1.3 1 0 0 1 1 1 0 Neuraminidase-like domain Pkinase PF00069.25 ETO06026.1 - 2.4e-18 66.4 0.2 5.7e-11 42.3 0.1 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06026.1 - 6.9e-09 35.4 0.1 5.2e-07 29.2 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO06026.1 - 0.00073 19.0 0.2 0.0012 18.2 0.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_P35 PF03213.14 ETO06028.1 - 0.02 14.1 0.1 0.021 14.1 0.1 1.1 1 0 0 1 1 1 0 Poxvirus P35 protein Ank_2 PF12796.7 ETO06029.1 - 4.1e-20 72.2 0.7 1.9e-12 47.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO06029.1 - 4.1e-19 66.7 0.1 4e-06 26.8 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ETO06029.1 - 2.8e-18 65.7 1.0 1.1e-05 25.7 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO06029.1 - 1.2e-17 64.0 1.3 7.7e-12 45.5 0.2 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO06029.1 - 5.6e-16 58.2 3.1 2.3e-05 24.6 0.1 4.1 4 0 0 4 4 4 3 Ankyrin repeat Rad51 PF08423.11 ETO06030.1 - 6.8e-14 51.7 0.2 1.2e-13 50.9 0.0 1.5 2 0 0 2 2 2 1 Rad51 ATPase PF06745.13 ETO06030.1 - 7.8e-05 22.1 2.3 0.0001 21.7 0.1 2.3 2 1 1 3 3 3 1 KaiC AAA_33 PF13671.6 ETO06030.1 - 0.0056 16.8 1.1 0.03 14.5 0.1 2.4 2 2 0 2 2 2 1 AAA domain AAA_25 PF13481.6 ETO06030.1 - 0.029 13.9 0.1 0.16 11.6 0.1 2.1 1 1 1 2 2 2 0 AAA domain Leader_CPA1 PF08252.11 ETO06030.1 - 0.054 12.9 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 arg-2/CPA1 leader peptide RecA PF00154.21 ETO06030.1 - 0.093 12.2 0.0 0.12 11.8 0.0 1.2 1 0 0 1 1 1 0 recA bacterial DNA recombination protein Cor1 PF04803.12 ETO06030.1 - 1.8 8.8 10.2 35 4.6 6.1 3.5 2 1 0 2 2 2 0 Cor1/Xlr/Xmr conserved region zf-CCCH PF00642.24 ETO06031.1 - 2.7e-07 30.3 4.4 4.6e-07 29.6 4.4 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO06031.1 - 0.0087 16.1 6.5 0.016 15.3 6.5 1.4 1 0 0 1 1 1 1 Zinc finger domain Csm1_N PF18504.1 ETO06031.1 - 0.013 15.8 3.1 1.3 9.4 3.5 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain ABC_tran_CTD PF16326.5 ETO06031.1 - 0.032 14.5 0.6 0.074 13.3 0.6 1.5 1 0 0 1 1 1 0 ABC transporter C-terminal domain Osmo_CC PF08946.10 ETO06031.1 - 0.062 13.6 1.8 0.062 13.6 1.8 1.9 2 0 0 2 2 2 0 Osmosensory transporter coiled coil TBK1_ULD PF18396.1 ETO06031.1 - 0.075 13.0 1.5 2.2 8.2 0.2 2.5 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain BAR_3 PF16746.5 ETO06031.1 - 0.092 12.4 2.4 0.21 11.3 1.0 2.1 1 1 1 2 2 2 0 BAR domain of APPL family Pex16 PF08610.10 ETO06032.1 - 3.7e-20 72.4 0.0 4.7e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) RXT2_N PF08595.11 ETO06032.1 - 0.007 16.4 1.7 0.011 15.8 1.7 1.4 1 0 0 1 1 1 1 RXT2-like, N-terminal Sigma70_ner PF04546.13 ETO06032.1 - 0.039 13.8 2.1 0.066 13.1 2.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Pox_Ag35 PF03286.14 ETO06032.1 - 0.069 12.9 4.9 0.1 12.4 4.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ETO06032.1 - 0.27 9.5 6.4 0.36 9.1 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO06032.1 - 0.53 8.3 8.5 0.82 7.7 8.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ETO06032.1 - 2.5 7.8 4.5 4.6 6.9 4.5 1.4 1 0 0 1 1 1 0 FAM176 family Orf78 PF06024.12 ETO06032.1 - 2.6 8.4 6.5 0.58 10.5 1.2 2.2 2 0 0 2 2 2 0 Orf78 (ac78) SOBP PF15279.6 ETO06034.1 - 2.4 8.7 36.4 0.04 14.5 25.9 2.1 2 0 0 2 2 2 0 Sine oculis-binding protein WD40 PF00400.32 ETO06036.1 - 2.2e-25 88.4 17.9 2.4e-05 25.0 0.8 6.6 6 1 0 6 6 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06036.1 - 7.6e-10 39.0 0.3 0.0082 16.4 0.1 5.2 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06036.1 - 0.00029 19.6 0.1 0.077 11.6 0.0 2.9 3 0 0 3 3 3 1 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO06036.1 - 0.0019 18.1 0.0 0.59 10.0 0.0 3.1 3 0 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A FlxA PF14282.6 ETO06036.1 - 0.048 13.6 11.2 0.13 12.2 11.2 1.7 1 0 0 1 1 1 0 FlxA-like protein Topoisom_I PF01028.20 ETO06036.1 - 0.05 12.8 5.3 0.078 12.2 5.3 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, catalytic core Allexi_40kDa PF05549.11 ETO06036.1 - 0.065 12.7 1.5 0.1 12.1 1.5 1.4 1 0 0 1 1 1 0 Allexivirus 40kDa protein Dynamitin PF04912.14 ETO06036.1 - 0.071 12.4 5.3 0.09 12.1 5.3 1.2 1 0 0 1 1 1 0 Dynamitin DUF4795 PF16043.5 ETO06036.1 - 0.086 12.4 9.2 0.13 11.9 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) KIND PF16474.5 ETO06036.1 - 0.16 11.9 1.8 0.3 11.0 1.8 1.4 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain Cob_adeno_trans PF01923.18 ETO06036.1 - 0.16 12.1 1.7 0.25 11.5 1.7 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase BING4CT PF08149.11 ETO06036.1 - 0.23 11.3 1.0 4.1 7.3 0.0 3.2 3 1 1 4 4 4 0 BING4CT (NUC141) domain DUF724 PF05266.14 ETO06036.1 - 0.28 11.0 9.6 0.49 10.2 9.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Csm1_N PF18504.1 ETO06036.1 - 1 9.8 12.6 5.4 7.4 1.7 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain ACCA PF03255.14 ETO06036.1 - 1.1 9.2 5.0 1.8 8.4 5.0 1.3 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit XhlA PF10779.9 ETO06036.1 - 1.3 9.3 4.7 2.8 8.2 4.7 1.5 1 0 0 1 1 1 0 Haemolysin XhlA HemX PF04375.14 ETO06036.1 - 1.8 7.7 7.4 2.6 7.2 7.4 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase BST2 PF16716.5 ETO06036.1 - 2.6 8.7 10.0 5 7.8 10.0 1.4 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 TMPIT PF07851.13 ETO06036.1 - 6.5 5.9 7.5 9 5.4 7.5 1.1 1 0 0 1 1 1 0 TMPIT-like protein TPR_12 PF13424.6 ETO06037.1 - 2.8e-49 165.3 5.3 2.2e-15 56.7 0.9 6.1 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06037.1 - 1.1e-26 91.5 32.9 7.7e-06 25.5 1.1 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06037.1 - 1.7e-24 84.0 13.5 0.0051 16.8 0.1 8.6 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06037.1 - 7.9e-24 82.8 5.0 0.0005 19.9 0.0 7.8 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06037.1 - 5.5e-23 79.2 37.9 8.6e-06 25.6 0.2 9.6 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06037.1 - 6.1e-21 72.8 28.9 6.8e-05 22.7 0.1 9.6 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO06037.1 - 1.4e-12 47.6 0.0 2.4e-07 30.5 0.0 3.0 1 1 2 3 3 3 3 MalT-like TPR region TPR_16 PF13432.6 ETO06037.1 - 2.1e-08 34.7 0.1 0.51 11.0 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO06037.1 - 2.1e-08 34.0 1.9 18 6.0 0.0 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06037.1 - 9.4e-08 32.2 13.8 0.00091 19.7 0.1 6.4 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO06037.1 - 1.1e-07 32.0 1.6 10 7.3 0.0 6.3 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO06037.1 - 5.1e-05 23.7 2.0 6.5 7.3 0.0 4.8 4 1 2 6 6 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO06037.1 - 0.00015 21.9 12.6 0.024 14.9 0.0 5.3 3 2 2 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO06037.1 - 0.0011 18.7 14.3 5.4 6.8 0.1 6.2 3 2 3 6 6 6 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO06037.1 - 0.038 13.7 0.2 0.038 13.7 0.2 6.1 7 1 1 8 8 8 0 TPR repeat TPR_21 PF09976.9 ETO06037.1 - 0.044 13.5 2.1 0.12 12.1 0.0 2.7 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain Fis1_TPR_C PF14853.6 ETO06037.1 - 0.045 13.8 10.8 0.44 10.7 0.0 4.5 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat SCAB-PH PF17684.1 ETO06037.1 - 0.14 12.4 0.0 2.5 8.4 0.0 2.9 3 0 0 3 3 3 0 PH domain of plant-specific actin-binding protein Mob_Pre PF01076.19 ETO06037.1 - 0.29 10.9 6.1 0.66 9.8 0.1 3.3 3 1 0 3 3 3 0 Plasmid recombination enzyme MIT PF04212.18 ETO06037.1 - 1.3 9.2 15.0 62 3.8 0.2 5.8 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain WD40 PF00400.32 ETO06038.1 - 1.1e-135 437.5 50.7 8.3e-09 35.9 0.0 16.4 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06038.1 - 1.9e-31 108.2 18.4 0.015 15.5 0.0 13.5 1 1 14 15 15 15 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06038.1 - 1.7e-24 86.4 10.9 0.011 14.7 0.0 13.2 1 1 12 14 14 14 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO06038.1 - 5.2e-13 49.0 32.1 0.00019 20.9 0.1 9.4 3 2 8 12 12 12 8 WD40-like domain Pentapeptide PF00805.22 ETO06038.1 - 2e-07 30.5 1.1 4.7e-07 29.3 1.1 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) SGL PF08450.12 ETO06038.1 - 4.3e-06 26.5 1.5 0.032 13.8 0.0 4.7 3 1 1 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO06038.1 - 1.9e-05 23.4 9.5 1.9 7.0 0.1 5.7 5 1 1 6 6 6 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO06038.1 - 0.00012 22.2 15.1 14 5.8 0.1 9.4 6 3 5 11 11 11 0 Family of unknown function (DUF5570) Pentapeptide_4 PF13599.6 ETO06038.1 - 0.00017 21.7 0.1 0.00051 20.2 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO06038.1 - 0.001 18.5 10.0 15 4.8 0.0 7.0 2 2 5 9 9 9 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO06038.1 - 0.0065 16.4 19.9 12 6.0 0.0 8.8 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat Mid2 PF04478.12 ETO06038.1 - 0.023 14.6 4.6 2.5 7.9 0.0 5.5 5 1 0 6 6 6 0 Mid2 like cell wall stress sensor Pentapeptide_3 PF13576.6 ETO06038.1 - 0.046 13.9 0.2 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Ras_bdg_2 PF14847.6 ETO06038.1 - 0.087 13.2 0.8 0.49 10.8 0.8 2.3 1 1 0 1 1 1 0 Ras-binding domain of Byr2 SHMT PF00464.19 ETO06038.1 - 0.13 10.8 1.0 0.25 9.9 0.6 1.6 2 0 0 2 2 2 0 Serine hydroxymethyltransferase BLUF PF04940.12 ETO06038.1 - 0.36 11.0 5.1 47 4.2 0.0 6.2 9 0 0 9 9 8 0 Sensors of blue-light using FAD WD40 PF00400.32 ETO06039.1 - 1.1e-08 35.5 0.1 8.9e-05 23.2 0.1 2.5 2 2 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO06039.1 - 0.079 11.6 0.0 0.084 11.5 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 zf-RING_11 PF17123.5 ETO06041.1 - 2.2e-06 27.3 2.9 7.3e-06 25.6 2.9 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO06041.1 - 1e-05 25.3 3.4 1e-05 25.3 3.4 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO06041.1 - 4.4e-05 23.4 10.7 5.3e-05 23.1 2.4 2.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO06041.1 - 4.5e-05 23.4 2.8 4.5e-05 23.4 2.8 2.9 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO06041.1 - 4.9e-05 23.1 3.2 4.9e-05 23.1 3.2 3.0 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO06041.1 - 5.1e-05 23.5 3.4 5.1e-05 23.5 3.4 3.3 3 0 0 3 3 3 2 Ring finger domain zf-C3HC4_3 PF13920.6 ETO06041.1 - 0.0034 17.2 15.3 0.0055 16.5 2.4 2.8 2 1 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO06041.1 - 0.0083 16.4 1.0 0.0083 16.4 1.0 3.2 2 1 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ETO06041.1 - 0.19 11.6 16.7 0.27 11.1 4.2 2.8 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 VWA PF00092.28 ETO06042.1 - 0.00029 21.1 0.0 0.00046 20.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF2723 PF11028.8 ETO06043.1 - 0.0013 18.7 1.1 0.0018 18.2 1.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2723) YqhR PF11085.8 ETO06043.1 - 0.023 14.7 1.8 0.035 14.0 1.8 1.3 1 0 0 1 1 1 0 Conserved membrane protein YqhR AdoHcyase PF05221.17 ETO06046.1 - 2.3e-109 365.1 0.5 3.4e-109 364.6 0.5 1.2 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase AdoHcyase_NAD PF00670.21 ETO06046.1 - 5.9e-33 114.2 6.7 9.1e-19 68.1 1.5 2.4 1 1 1 2 2 2 2 S-adenosyl-L-homocysteine hydrolase, NAD binding domain BALF1 PF06861.11 ETO06046.1 - 0.045 13.4 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 BALF1 protein Shikimate_DH PF01488.20 ETO06046.1 - 0.076 13.1 0.3 0.25 11.4 0.1 1.8 1 1 1 2 2 2 0 Shikimate / quinate 5-dehydrogenase FRG2 PF15315.6 ETO06046.1 - 0.1 12.8 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 WD40 PF00400.32 ETO06047.1 - 3.2e-16 59.4 11.0 5.6e-08 33.3 1.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO06047.1 - 1.2e-06 27.5 0.6 0.0027 16.4 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06047.1 - 0.00091 19.5 0.2 0.0096 16.2 0.0 2.1 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06047.1 - 0.0049 16.2 1.4 0.068 12.5 0.3 2.0 1 1 1 2 2 2 1 WD40-like domain WD40 PF00400.32 ETO06048.1 - 1.3e-07 32.1 0.3 0.0059 17.4 0.1 3.2 2 1 0 2 2 2 2 WD domain, G-beta repeat PUB PF09409.10 ETO06050.1 - 0.00067 19.5 1.4 0.00067 19.5 1.4 3.4 3 2 0 3 3 3 1 PUB domain Imm30 PF15565.6 ETO06050.1 - 0.084 13.0 3.0 0.22 11.6 2.3 2.1 1 1 0 1 1 1 0 Immunity protein 30 DUF775 PF05603.12 ETO06052.1 - 1.1 8.8 8.5 0.15 11.6 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF775) Kinesin PF00225.23 ETO06053.1 - 0.0032 16.4 0.4 0.011 14.7 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain Pih1_fungal_CS PF18482.1 ETO06053.1 - 0.012 16.1 0.1 0.018 15.5 0.1 1.3 1 0 0 1 1 1 0 Fungal Pih1 CS domain WD40 PF00400.32 ETO06054.1 - 5.4e-36 122.0 21.2 9.2e-08 32.6 0.6 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06054.1 - 1.3e-11 44.7 1.2 0.1 12.9 0.0 4.9 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06054.1 - 2.7e-11 42.8 5.3 0.0003 19.6 0.0 4.8 2 2 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06054.1 - 2.2e-06 27.3 5.1 0.28 10.5 0.1 4.8 2 2 3 5 5 5 3 WD40-like domain SH3_1 PF00018.28 ETO06056.1 - 8.7e-06 25.2 0.0 0.24 11.1 0.0 4.1 4 0 0 4 4 4 2 SH3 domain SH3_2 PF07653.17 ETO06056.1 - 0.00014 21.5 0.1 0.014 15.1 0.0 3.4 3 1 0 3 3 3 1 Variant SH3 domain SH3_10 PF17902.1 ETO06056.1 - 0.034 14.2 0.0 0.3 11.2 0.0 2.5 2 1 0 2 2 2 0 SH3 domain Acetyltransf_16 PF05301.11 ETO06057.1 - 1.7e-52 177.7 0.2 2.7e-52 177.0 0.2 1.3 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Acetyltransf_7 PF13508.7 ETO06057.1 - 0.021 15.3 0.0 0.043 14.2 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO06057.1 - 0.049 13.9 0.0 0.071 13.4 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO06057.1 - 0.11 12.4 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain 14-3-3 PF00244.20 ETO06058.1 - 1.1e-44 152.6 3.8 7e-28 97.7 0.2 2.1 1 1 1 2 2 2 2 14-3-3 protein IL17R_fnIII_D1 PF16556.5 ETO06058.1 - 0.023 14.4 0.0 0.034 13.8 0.0 1.2 1 0 0 1 1 1 0 Interleukin-17 receptor, fibronectin-III-like domain 1 Ras PF00071.22 ETO06059.1 - 1e-11 44.7 0.7 5.4e-08 32.6 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO06059.1 - 9.5e-05 22.6 0.0 0.00051 20.3 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO06059.1 - 0.025 14.0 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO06059.1 - 0.046 13.2 0.2 0.11 12.0 0.2 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PIG-F PF06699.11 ETO06059.1 - 0.077 13.2 1.9 0.13 12.4 1.9 1.4 1 0 0 1 1 1 0 GPI biosynthesis protein family Pig-F PRCH PF03967.13 ETO06059.1 - 0.39 11.0 1.3 0.75 10.0 1.3 1.5 1 0 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region SecA_DEAD PF07517.14 ETO06061.1 - 0.00039 19.8 0.0 0.00043 19.7 0.0 1.1 1 0 0 1 1 1 1 SecA DEAD-like domain FTR1 PF03239.14 ETO06061.1 - 0.014 14.5 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 Iron permease FTR1 family Kelch_1 PF01344.25 ETO06062.1 - 4.5e-07 29.3 0.2 0.039 13.5 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO06062.1 - 3.8e-06 27.0 0.7 1.2 9.6 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 ETO06062.1 - 8.4e-06 25.7 1.1 4.3 7.4 0.0 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 ETO06062.1 - 0.00048 20.1 0.5 0.64 10.1 0.1 3.2 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06062.1 - 0.001 19.0 0.6 8.9 6.5 0.1 4.4 4 0 0 4 4 4 2 Kelch motif TLD PF07534.16 ETO06062.1 - 0.019 15.1 5.0 0.028 14.6 0.3 2.9 1 1 2 3 3 3 0 TLD WD40 PF00400.32 ETO06063.1 - 4.3e-21 74.8 3.9 7.5e-10 39.2 0.2 4.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06063.1 - 3.6e-05 24.0 0.1 0.043 14.1 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Na_Ca_ex_C PF16494.5 ETO06063.1 - 0.77 10.2 6.6 5.5 7.5 2.2 2.4 2 0 0 2 2 2 0 C-terminal extension of sodium/calcium exchanger domain Pet20 PF08692.10 ETO06063.1 - 3.5 8.4 8.7 6.6 7.5 1.5 3.2 3 0 0 3 3 3 0 Mitochondrial protein Pet20 DUF1722 PF08349.11 ETO06064.1 - 0.071 13.4 0.2 4.9 7.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) zf-TRAF PF02176.18 ETO06065.1 - 1.3e-05 25.8 2.2 6.5e-05 23.5 2.2 2.3 1 0 0 1 1 1 1 TRAF-type zinc finger Kelch_4 PF13418.6 ETO06065.1 - 0.007 16.4 0.4 0.054 13.5 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO06065.1 - 0.12 12.4 1.9 0.4 10.7 0.8 2.5 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO06066.1 - 1.4e-26 92.2 9.5 1.4e-08 35.2 0.7 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06066.1 - 1.5e-12 47.7 1.3 0.017 15.4 0.0 5.4 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06066.1 - 2.5e-08 33.3 0.1 0.0023 17.0 0.0 4.2 2 2 1 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO06066.1 - 0.00027 20.3 1.4 0.027 13.8 0.3 2.8 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO06066.1 - 0.0014 17.4 3.2 0.39 9.3 0.4 3.4 2 2 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO06066.1 - 0.0054 16.6 0.3 3.5 7.7 0.0 3.7 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO06066.1 - 0.022 14.9 0.0 16 5.6 0.0 3.5 2 2 1 3 3 3 0 Family of unknown function (DUF5570) PT PF04886.12 ETO06067.1 - 1e-62 207.3 197.4 6.6e-10 38.4 7.5 13.9 2 2 8 10 10 10 9 PT repeat SPATA9 PF15824.5 ETO06069.1 - 0.058 12.7 0.8 0.072 12.4 0.8 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated protein 9 Radical_SAM PF04055.21 ETO06070.1 - 4.1e-08 33.8 0.0 5.1e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 Radical SAM superfamily Kelch_5 PF13854.6 ETO06072.1 - 0.00017 21.5 0.1 0.0025 17.8 0.1 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO06072.1 - 0.0084 16.4 0.0 0.26 11.6 0.0 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO06072.1 - 0.015 14.9 0.4 0.085 12.5 0.1 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO06072.1 - 0.11 12.5 0.0 1.6 8.8 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO06072.1 - 0.11 12.5 0.0 0.34 10.9 0.0 1.8 1 0 0 1 1 1 0 Galactose oxidase, central domain DUF2599 PF10783.9 ETO06073.1 - 0.022 15.4 0.8 0.22 12.2 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2599) Orf78 PF06024.12 ETO06074.1 - 2 8.8 7.7 0.19 12.0 1.5 2.4 2 0 0 2 2 2 0 Orf78 (ac78) CorA PF01544.18 ETO06074.1 - 8.4 5.6 8.3 14 4.8 8.3 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Chlam_PMP PF02415.17 ETO06075.1 - 0.6 10.7 0.1 0.6 10.7 0.1 7.5 8 0 0 8 8 8 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat HrpF PF06266.12 ETO06076.1 - 0.068 13.5 0.1 0.12 12.7 0.1 1.3 1 0 0 1 1 1 0 HrpF protein NADH-UOR_E PF16514.5 ETO06077.1 - 0.093 13.1 1.1 0.24 11.7 1.1 1.8 1 0 0 1 1 1 0 putative NADH-ubiquinone oxidoreductase chain E RTC PF01137.21 ETO06078.1 - 4.7e-24 84.8 0.0 5.5e-24 84.6 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ETO06078.1 - 8.9e-13 48.7 1.3 1.3e-11 44.9 1.3 2.2 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PX PF00787.24 ETO06079.1 - 1.3e-12 47.7 2.9 2.7e-12 46.7 2.9 1.5 1 0 0 1 1 1 1 PX domain DUF45 PF01863.17 ETO06080.1 - 0.006 16.7 2.8 0.006 16.7 2.8 2.0 1 1 0 2 2 2 1 Protein of unknown function DUF45 Baculo_PEP_C PF04513.12 ETO06080.1 - 0.25 11.4 3.9 1.8 8.6 0.5 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus IFRD PF05004.13 ETO06082.1 - 0.31 10.1 2.8 0.4 9.7 2.8 1.2 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) TPR_12 PF13424.6 ETO06084.1 - 2e-56 188.2 2.0 6.2e-16 58.5 0.1 4.9 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06084.1 - 1.2e-39 133.0 0.0 7.1e-10 38.4 0.0 6.0 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06084.1 - 1.4e-25 88.0 22.8 2.3e-07 30.3 1.6 5.2 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06084.1 - 5.9e-25 85.4 1.3 7e-06 25.7 0.0 4.7 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06084.1 - 6e-24 82.2 24.6 1.1e-05 25.2 0.5 5.3 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06084.1 - 2.4e-22 77.2 14.6 0.00012 21.9 0.1 5.2 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO06084.1 - 5.1e-10 39.0 3.8 0.088 13.2 0.0 5.0 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06084.1 - 1.1e-09 38.8 0.0 0.077 13.7 0.0 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO06084.1 - 3.2e-09 36.8 0.0 0.025 15.4 0.0 4.4 2 1 2 4 4 4 2 Tetratricopeptide repeat SNAP PF14938.6 ETO06084.1 - 1.3e-08 34.7 0.6 1.1e-05 25.1 0.1 2.1 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO06084.1 - 3.5e-08 33.4 8.1 0.035 13.9 0.8 4.1 3 1 1 4 4 4 3 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO06084.1 - 5.2e-08 33.0 1.2 3.8 8.3 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06084.1 - 1.7e-07 30.8 23.4 0.015 14.9 0.2 6.6 4 2 3 7 7 7 3 TPR repeat TPR_3 PF07720.12 ETO06084.1 - 1.6e-05 24.8 7.7 0.79 9.8 0.4 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO06084.1 - 1.9e-05 25.1 0.3 0.023 15.2 0.0 3.4 1 1 3 4 4 4 1 Tetratricopeptide repeat PPR PF01535.20 ETO06084.1 - 6.2e-05 23.0 9.3 0.77 10.1 0.2 4.8 4 1 1 5 5 5 2 PPR repeat TPR_MalT PF17874.1 ETO06084.1 - 0.001 18.5 0.0 0.57 9.5 0.0 2.0 1 1 1 2 2 2 2 MalT-like TPR region TPR_21 PF09976.9 ETO06084.1 - 0.0014 18.4 7.0 0.086 12.5 0.1 3.4 2 1 0 2 2 2 1 Tetratricopeptide repeat-like domain RPN7 PF10602.9 ETO06084.1 - 0.004 16.9 7.9 3.1 7.5 0.0 4.0 1 1 3 4 4 4 1 26S proteasome subunit RPN7 Sel1 PF08238.12 ETO06084.1 - 0.011 16.4 1.9 49 4.8 0.0 4.3 4 0 0 4 4 4 0 Sel1 repeat HDV_ag PF01517.18 ETO06084.1 - 0.051 13.4 0.8 0.32 10.8 0.4 2.1 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen TPR_9 PF13371.6 ETO06084.1 - 0.062 13.5 0.0 0.26 11.5 0.0 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETO06084.1 - 0.38 10.8 18.4 14 5.9 0.2 5.0 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Peripla_BP_7 PF18610.1 ETO06084.1 - 0.89 9.7 6.7 8.3 6.6 0.1 3.3 2 2 1 3 3 3 0 Periplasmic binding protein domain Clathrin PF00637.20 ETO06084.1 - 1.3 8.8 7.3 29 4.5 0.1 3.8 3 1 1 4 4 4 0 Region in Clathrin and VPS Fis1_TPR_C PF14853.6 ETO06084.1 - 6.4 6.9 14.6 9.8 6.3 0.1 4.6 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat NACHT PF05729.12 ETO06085.1 - 3.1e-11 43.5 0.2 1.7e-10 41.0 0.1 2.1 2 1 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 ETO06085.1 - 0.0014 17.9 0.1 0.0022 17.2 0.1 1.4 1 0 0 1 1 1 1 NB-ARC domain Mg_chelatase PF01078.21 ETO06085.1 - 0.0028 17.1 0.0 0.05 13.0 0.0 2.1 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI THDPS_N PF14790.6 ETO06085.1 - 0.011 15.6 0.1 0.02 14.7 0.1 1.4 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal AAA_16 PF13191.6 ETO06085.1 - 0.012 16.0 0.0 0.051 13.9 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ETO06085.1 - 0.019 15.3 0.3 0.33 11.4 0.0 2.4 2 1 0 2 2 2 0 RNA helicase LAGLIDADG_2 PF03161.13 ETO06085.1 - 0.03 14.4 0.4 0.046 13.8 0.3 1.4 1 1 0 1 1 1 0 LAGLIDADG DNA endonuclease family SMC_N PF02463.19 ETO06085.1 - 0.041 13.3 0.0 0.093 12.1 0.0 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ETO06085.1 - 0.049 13.9 0.3 0.18 12.1 0.1 2.2 2 1 0 2 2 2 0 AAA domain DUF2130 PF09903.9 ETO06086.1 - 2.7e-74 249.7 0.2 2.7e-74 249.7 0.2 3.0 1 1 2 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2130) Phage_GP20 PF06810.11 ETO06086.1 - 0.015 15.1 1.7 0.015 15.1 1.7 3.6 2 1 2 4 4 4 0 Phage minor structural protein GP20 LEM PF03020.15 ETO06086.1 - 0.11 12.1 0.0 0.28 10.8 0.0 1.7 1 0 0 1 1 1 0 LEM domain UPF0242 PF06785.11 ETO06086.1 - 2.2 8.4 42.0 8.1 6.5 0.2 3.2 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF148 PF02520.17 ETO06086.1 - 3.9 7.6 27.0 4.7 7.4 2.5 3.5 2 1 0 3 3 3 0 Domain of unknown function DUF148 Spc7 PF08317.11 ETO06086.1 - 8 5.2 42.9 0.86 8.4 25.2 2.8 2 1 1 3 3 3 0 Spc7 kinetochore protein GTP_EFTU PF00009.27 ETO06087.1 - 2.5e-13 50.0 0.0 7.2e-11 42.0 0.0 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF764 PF05561.11 ETO06087.1 - 0.033 14.0 0.0 0.046 13.5 0.0 1.2 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF764) RR_TM4-6 PF06459.12 ETO06089.1 - 0.1 12.4 8.2 0.19 11.6 8.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Connexin PF00029.19 ETO06089.1 - 0.13 12.0 3.6 0.27 11.0 3.6 1.4 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ETO06089.1 - 0.15 11.2 1.9 0.21 10.8 1.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2072 PF09845.9 ETO06089.1 - 0.34 11.2 10.9 0.72 10.1 10.9 1.5 1 0 0 1 1 1 0 Zn-ribbon containing protein Spt20 PF12090.8 ETO06089.1 - 0.45 10.1 20.7 0.11 12.1 17.0 1.8 2 0 0 2 2 2 0 Spt20 family Androgen_recep PF02166.16 ETO06089.1 - 0.76 8.6 10.0 0.96 8.2 10.0 1.1 1 0 0 1 1 1 0 Androgen receptor O-antigen_lig PF13425.6 ETO06089.1 - 1.3 7.7 7.2 2.1 7.0 7.2 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 ETO06089.1 - 2 7.1 10.8 3.1 6.4 10.8 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 ETO06089.1 - 4.6 6.2 5.9 8.5 5.3 5.9 1.4 1 0 0 1 1 1 0 CLN3 protein PBP1_TM PF14812.6 ETO06091.1 - 0.35 11.3 5.1 0.72 10.3 5.1 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3245 PF11595.8 ETO06091.1 - 9.8 6.6 11.1 2.2 8.7 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) BORCS7 PF16088.5 ETO06093.1 - 0.068 13.4 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 WD40 PF00400.32 ETO06094.1 - 2.3e-16 59.8 11.6 2e-05 25.3 0.0 5.0 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06094.1 - 2.3e-05 24.6 0.8 0.85 10.0 0.0 3.9 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06094.1 - 0.00058 18.6 2.8 1.1 7.8 0.1 3.7 2 1 2 4 4 4 2 Nucleoporin Nup120/160 RNase_H PF00075.24 ETO06095.1 - 3.5e-14 53.2 0.0 5e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETO06095.1 - 0.045 13.6 0.0 0.067 13.0 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase-like VacA PF02691.15 ETO06096.1 - 0.071 11.0 0.0 0.096 10.5 0.0 1.1 1 0 0 1 1 1 0 Vacuolating cyotoxin DUF3439 PF11921.8 ETO06096.1 - 0.095 12.7 5.1 0.13 12.2 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Glyco_trans_4_5 PF16994.5 ETO06097.1 - 2.6 7.6 5.1 0.28 10.8 0.6 1.7 2 0 0 2 2 2 0 Glycosyl-transferase family 4 HMG_box_5 PF14887.6 ETO06097.1 - 3.6 7.6 7.4 0.27 11.2 0.6 2.6 2 1 1 3 3 3 0 HMG (high mobility group) box 5 Exo_endo_phos_2 PF14529.6 ETO06098.1 - 1.3e-10 41.2 1.8 1.5e-10 41.0 0.1 1.9 2 1 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO06098.1 - 0.0058 16.2 0.0 0.014 14.9 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RVT_1 PF00078.27 ETO06099.1 - 1.1e-23 83.9 1.6 1.1e-23 83.9 1.6 2.4 2 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cas6b_C PF17262.2 ETO06099.1 - 0.017 15.2 0.7 0.017 15.2 0.7 2.9 3 1 1 4 4 4 0 Cas6b C-terminal domain Glyco_hydro_10 PF00331.20 ETO06099.1 - 0.023 13.9 0.4 0.043 13.0 0.4 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 10 Atypical_Card PF18461.1 ETO06099.1 - 0.39 11.0 2.9 0.37 11.0 0.4 2.3 2 0 0 2 2 2 0 Atypical caspase recruitment domain WD40 PF00400.32 ETO06100.1 - 7.6e-19 67.7 8.9 5.9e-06 26.9 0.5 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06100.1 - 1.9e-06 28.1 0.1 0.02 15.2 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06100.1 - 2.3e-05 23.2 0.6 0.29 9.7 0.0 2.9 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06100.1 - 0.00013 21.4 1.2 0.085 12.2 0.3 2.3 1 1 1 2 2 2 2 WD40-like domain CRT10 PF08728.10 ETO06100.1 - 0.0012 17.1 3.9 0.0042 15.3 3.3 1.8 1 1 1 2 2 2 1 CRT10 Kelch_1 PF01344.25 ETO06101.1 - 5.4e-06 25.9 0.5 0.31 10.7 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO06101.1 - 1.5e-05 25.0 1.8 0.12 12.7 0.1 3.6 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO06101.1 - 2.4e-05 24.2 0.0 0.47 10.5 0.0 3.0 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06101.1 - 0.00085 19.2 0.4 4.8 7.3 0.0 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO06101.1 - 0.0012 18.8 7.7 1.8 8.7 0.4 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 ETO06102.1 - 0.0017 18.3 0.4 0.0084 16.1 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO06102.1 - 0.0073 16.6 0.6 0.033 14.5 0.1 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO06102.1 - 0.0073 16.2 0.4 8.4 6.5 0.0 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO06102.1 - 0.011 15.3 0.7 0.081 12.5 0.1 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO06102.1 - 0.05 13.6 0.1 0.72 9.9 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Zea_mays_MuDR PF05928.11 ETO06102.1 - 0.12 12.0 0.3 0.65 9.6 0.0 2.0 2 0 0 2 2 2 0 Zea mays MURB-like protein (MuDR) Sde2_N_Ubi PF13019.6 ETO06103.1 - 2e-18 66.8 0.4 2.8e-18 66.3 0.4 1.2 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain zf-CCCH_2 PF14608.6 ETO06103.1 - 3.1 8.4 7.4 6.7 7.4 7.4 1.6 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger Usp PF00582.26 ETO06104.1 - 0.029 14.9 0.0 0.041 14.4 0.0 1.2 1 0 0 1 1 1 0 Universal stress protein family SusF_SusE PF16411.5 ETO06104.1 - 0.093 13.3 0.2 0.12 12.9 0.2 1.2 1 0 0 1 1 1 0 Outer membrane protein SusF_SusE NikR_C PF08753.11 ETO06105.1 - 0.13 12.5 1.4 0.3 11.3 1.4 1.6 1 0 0 1 1 1 0 NikR C terminal nickel binding domain Eapp_C PF10238.9 ETO06105.1 - 0.6 10.2 13.3 0.41 10.7 7.5 2.4 1 1 1 2 2 2 0 E2F-associated phosphoprotein Transposase_24 PF03004.14 ETO06105.1 - 1.2 9.2 9.2 0.07 13.2 2.7 2.3 3 0 0 3 3 3 0 Plant transposase (Ptta/En/Spm family) DUF1635 PF07795.11 ETO06105.1 - 2 8.2 13.8 0.18 11.7 7.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) Secretin_N_2 PF07655.13 ETO06105.1 - 3.5 8.2 28.1 4.2 8.0 4.4 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF4400 PF14348.6 ETO06105.1 - 4.8 6.6 6.8 0.36 10.3 1.2 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4400) RVT_1 PF00078.27 ETO06106.1 - 2.5e-13 50.1 6.5 4.3e-08 32.9 1.1 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) WH1 PF00568.23 ETO06106.1 - 0.058 13.3 0.1 0.21 11.5 0.1 2.0 1 0 0 1 1 1 0 WH1 domain Exo_endo_phos_2 PF14529.6 ETO06107.1 - 0.00015 21.6 0.2 0.0005 19.9 0.0 2.0 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase NSs PF11073.8 ETO06107.1 - 0.004 16.6 0.1 0.0072 15.8 0.1 1.3 1 0 0 1 1 1 1 Rift valley fever virus non structural protein (NSs) like CT_C_D PF02682.16 ETO06107.1 - 0.12 12.1 0.1 2.5 7.8 0.0 2.7 3 0 0 3 3 3 0 Carboxyltransferase domain, subdomain C and D DUF3757 PF12582.8 ETO06107.1 - 0.37 11.2 2.6 0.48 10.8 1.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3757) WW_1 PF18507.1 ETO06107.1 - 1.1 9.0 3.2 1.3 8.7 0.6 2.4 3 0 0 3 3 3 0 WW domain Pox_A_type_inc PF04508.12 ETO06108.1 - 0.012 15.5 1.0 0.032 14.1 1.0 1.8 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat TPR_MLP1_2 PF07926.12 ETO06108.1 - 0.015 15.4 6.3 0.031 14.3 6.3 1.5 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO06108.1 - 0.57 9.5 2.8 0.8 9.0 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAB PF04382.13 ETO06108.1 - 4.3 7.5 6.4 0.85 9.7 1.1 2.4 2 0 0 2 2 2 0 SAB domain DUF3450 PF11932.8 ETO06109.1 - 0.0025 17.2 13.7 0.003 16.9 13.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DegS PF05384.11 ETO06109.1 - 0.003 17.1 7.2 0.0035 16.8 7.2 1.1 1 0 0 1 1 1 1 Sensor protein DegS bZIP_1 PF00170.21 ETO06109.1 - 0.0039 17.2 3.0 0.0039 17.2 3.0 2.2 1 1 1 2 2 2 1 bZIP transcription factor ZapB PF06005.12 ETO06109.1 - 0.015 15.7 11.5 0.015 15.7 11.5 2.3 1 1 1 2 2 2 0 Cell division protein ZapB Jnk-SapK_ap_N PF09744.9 ETO06109.1 - 0.018 15.3 13.7 0.022 15.0 13.7 1.1 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Golgin_A5 PF09787.9 ETO06109.1 - 0.032 13.7 11.2 0.036 13.5 11.2 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF1664 PF07889.12 ETO06109.1 - 0.032 14.3 5.4 0.04 13.9 5.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Allexi_40kDa PF05549.11 ETO06109.1 - 0.037 13.5 4.8 0.038 13.5 4.8 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein BLOC1_2 PF10046.9 ETO06109.1 - 0.072 13.4 7.7 0.3 11.4 6.8 2.2 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RasGAP_C PF03836.15 ETO06109.1 - 0.077 13.1 8.6 0.11 12.7 8.3 1.5 1 1 0 1 1 1 0 RasGAP C-terminus KxDL PF10241.9 ETO06109.1 - 0.1 12.9 8.9 0.11 12.8 8.4 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein TSC22 PF01166.18 ETO06109.1 - 0.1 12.9 8.1 0.82 10.0 6.9 2.4 2 1 0 2 2 2 0 TSC-22/dip/bun family HMMR_N PF15905.5 ETO06109.1 - 0.17 11.3 14.5 0.17 11.3 14.5 1.0 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF3573 PF12097.8 ETO06109.1 - 0.3 9.8 7.6 0.32 9.8 7.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DHR10 PF18595.1 ETO06109.1 - 0.33 11.0 13.2 0.12 12.5 10.0 1.7 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain Spc24 PF08286.11 ETO06109.1 - 0.37 11.0 8.1 0.24 11.7 6.1 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Peptidase_C6 PF00851.18 ETO06109.1 - 0.38 9.6 6.3 0.44 9.4 6.3 1.0 1 0 0 1 1 1 0 Helper component proteinase TMPIT PF07851.13 ETO06109.1 - 0.41 9.8 8.1 0.46 9.7 8.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 ETO06109.1 - 0.63 8.6 9.2 0.62 8.6 9.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A SecD-TM1 PF13721.6 ETO06109.1 - 0.97 9.9 5.7 1.2 9.7 5.0 1.6 1 1 1 2 2 2 0 SecD export protein N-terminal TM region APG6_N PF17675.1 ETO06109.1 - 1 9.9 14.7 1.3 9.6 14.7 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Prp19 PF08606.11 ETO06109.1 - 1.5 8.9 7.8 0.74 9.8 5.1 2.1 2 1 1 3 3 2 0 Prp19/Pso4-like UPF0449 PF15136.6 ETO06109.1 - 1.8 9.1 10.7 0.72 10.4 5.8 2.3 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 DUF1003 PF06210.11 ETO06109.1 - 1.8 8.7 6.2 8 6.6 1.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1003) PRKG1_interact PF15898.5 ETO06109.1 - 1.8 9.5 11.2 8.5 7.3 10.0 2.1 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 ETO06109.1 - 2.2 9.0 9.8 5 7.8 7.1 2.1 1 1 1 2 2 2 0 Initiation control protein YabA SUIM_assoc PF16619.5 ETO06109.1 - 2.3 8.4 12.8 0.11 12.6 6.8 1.9 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 YlqD PF11068.8 ETO06109.1 - 4 7.8 17.3 2.3 8.6 12.9 1.8 1 1 0 1 1 1 0 YlqD protein OmpH PF03938.14 ETO06109.1 - 6.4 7.1 14.8 5.4 7.3 13.7 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Rotamase PF00639.21 ETO06110.1 - 5.3e-17 62.6 0.0 8.3e-17 61.9 0.0 1.3 1 0 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ETO06110.1 - 1.4e-14 54.6 0.1 2.6e-14 53.7 0.1 1.4 1 1 0 1 1 1 1 PPIC-type PPIASE domain Rotamase_2 PF13145.6 ETO06110.1 - 4.7e-05 24.2 0.0 6.2e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 PPIC-type PPIASE domain Fibin PF15819.5 ETO06110.1 - 0.019 14.8 0.0 0.021 14.6 0.0 1.1 1 0 0 1 1 1 0 Fin bud initiation factor homologue NDUFA12 PF05071.16 ETO06111.1 - 0.084 13.7 13.3 8.2 7.3 13.3 2.6 1 1 0 1 1 1 0 NADH ubiquinone oxidoreductase subunit NDUFA12 ARGLU PF15346.6 ETO06111.1 - 3.9 7.4 25.5 0.066 13.1 16.6 2.0 1 1 1 2 2 2 0 Arginine and glutamate-rich 1 LMBR1 PF04791.16 ETO06111.1 - 4 6.2 9.5 5 5.9 9.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein PH_12 PF16457.5 ETO06112.1 - 9.8e-06 26.1 0.1 9.8e-06 26.1 0.1 3.2 1 1 2 3 3 3 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO06112.1 - 0.00022 21.3 0.0 0.00077 19.6 0.0 1.9 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology CDC45 PF02724.14 ETO06112.1 - 0.048 11.9 9.5 0.071 11.4 9.5 1.3 1 0 0 1 1 1 0 CDC45-like protein CDK2AP PF09806.9 ETO06112.1 - 0.49 10.4 8.4 1.5 8.8 8.4 1.8 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein FAD_binding_2 PF00890.24 ETO06113.1 - 1.6e-73 248.2 0.3 5.4e-45 154.2 0.0 2.1 1 1 1 2 2 2 2 FAD binding domain Succ_DH_flav_C PF02910.20 ETO06113.1 - 1.2e-41 141.7 0.3 1.7e-41 141.2 0.3 1.2 1 0 0 1 1 1 1 Fumarate reductase flavoprotein C-term Spc7 PF08317.11 ETO06114.1 - 0.0024 16.8 11.4 0.003 16.5 11.4 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein RPW8 PF05659.11 ETO06114.1 - 0.047 13.4 0.4 0.047 13.4 0.4 1.9 1 1 1 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 BLOC1_2 PF10046.9 ETO06114.1 - 0.21 11.9 7.0 0.15 12.3 4.7 1.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.22 ETO06114.1 - 0.25 11.6 10.6 0.12 12.6 7.9 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Fmp27_WPPW PF10359.9 ETO06114.1 - 0.41 9.4 11.8 0.5 9.1 11.8 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF3573 PF12097.8 ETO06114.1 - 0.43 9.3 3.2 0.53 9.1 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) IFT20 PF14931.6 ETO06114.1 - 0.78 9.9 14.0 0.12 12.5 9.2 2.1 1 1 2 3 3 3 0 Intraflagellar transport complex B, subunit 20 Baculo_p24 PF05073.12 ETO06114.1 - 0.88 9.3 5.4 2.5 7.9 5.4 1.7 1 1 0 1 1 1 0 Baculovirus P24 capsid protein Atg14 PF10186.9 ETO06114.1 - 2.2 7.3 15.1 2.5 7.1 15.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Com_YlbF PF06133.11 ETO06114.1 - 2.5 8.8 15.5 0.64 10.6 1.6 2.2 1 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA DUF3450 PF11932.8 ETO06114.1 - 2.5 7.3 11.5 3.6 6.8 11.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 ETO06114.1 - 3.6 6.8 8.6 4.5 6.5 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 ETO06114.1 - 4.2 6.1 6.7 5.1 5.8 6.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FapA PF03961.13 ETO06114.1 - 5.1 5.6 13.1 6.5 5.3 13.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A WD40 PF00400.32 ETO06115.1 - 8.9e-41 137.1 12.2 7.2e-08 33.0 1.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06115.1 - 3e-10 40.3 1.0 0.019 15.3 0.1 4.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06115.1 - 2.4e-07 29.8 4.5 0.21 10.2 0.0 4.9 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO06115.1 - 3e-07 30.0 0.4 8.9e-07 28.4 0.4 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO06115.1 - 5.8e-05 23.2 0.1 0.00015 21.8 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) SGL PF08450.12 ETO06115.1 - 0.0012 18.5 0.2 1.1 8.8 0.0 2.6 1 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Pentapeptide_3 PF13576.6 ETO06115.1 - 0.0049 17.0 0.7 0.016 15.3 0.4 1.9 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO06115.1 - 0.02 13.5 0.3 0.52 8.8 0.1 2.3 2 1 1 3 3 3 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO06115.1 - 0.087 12.8 0.2 9.3 6.3 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Sod_Fe_C PF02777.18 ETO06118.1 - 2.2e-35 120.9 1.8 2.2e-35 120.9 1.8 1.4 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ETO06118.1 - 0.0039 17.6 0.1 0.0085 16.5 0.1 1.6 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Ran_BP1 PF00638.18 ETO06119.1 - 3.5e-06 27.3 0.0 5.1e-06 26.7 0.0 1.3 1 0 0 1 1 1 1 RanBP1 domain SprA-related PF12118.8 ETO06120.1 - 0.16 11.1 12.8 0.27 10.4 12.8 1.3 1 0 0 1 1 1 0 SprA-related family MSP1_C PF07462.11 ETO06120.1 - 6.1 5.4 7.5 9.5 4.8 7.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus DUF2400 PF09674.10 ETO06121.1 - 0.013 15.5 1.3 0.013 15.5 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2400) PH PF00169.29 ETO06123.1 - 2.7e-15 56.8 0.3 6.5e-15 55.5 0.3 1.7 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO06123.1 - 5.9e-08 32.8 2.3 1.6e-07 31.3 0.5 2.6 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO06123.1 - 2e-07 31.2 0.3 1.2e-06 28.7 0.3 2.3 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO06123.1 - 3.3e-06 27.5 2.2 0.00015 22.1 2.2 3.1 1 1 0 1 1 1 1 Pleckstrin homology domain Agenet PF05641.12 ETO06123.1 - 0.00022 21.6 0.2 0.00022 21.6 0.2 2.7 3 0 0 3 3 3 1 Agenet domain PH_9 PF15410.6 ETO06123.1 - 0.00032 21.1 0.1 0.0015 18.9 0.1 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain UBA2_C PF16195.5 ETO06123.1 - 0.011 16.4 0.2 0.024 15.3 0.2 1.5 1 0 0 1 1 1 0 SUMO-activating enzyme subunit 2 C-terminus SH3_1 PF00018.28 ETO06123.1 - 0.059 13.0 3.4 0.09 12.4 1.1 2.4 2 0 0 2 2 2 0 SH3 domain DUF4482 PF14818.6 ETO06123.1 - 0.075 13.9 5.3 0.16 12.9 5.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) Med4 PF10018.9 ETO06123.1 - 0.2 11.3 6.6 0.34 10.6 6.6 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF4201 PF13870.6 ETO06123.1 - 0.25 11.0 9.7 0.076 12.8 5.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) ADIP PF11559.8 ETO06123.1 - 0.31 11.1 6.5 1.3 9.1 7.0 1.7 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF2968 PF11180.8 ETO06123.1 - 0.36 10.4 5.2 0.67 9.6 5.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) TMF_DNA_bd PF12329.8 ETO06123.1 - 3.6 7.6 13.1 0.4 10.7 7.0 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding WD40 PF00400.32 ETO06124.1 - 1.6e-21 76.1 12.5 1.9e-05 25.3 0.1 6.2 5 1 1 6 6 6 4 WD domain, G-beta repeat PD40 PF07676.12 ETO06124.1 - 2.1e-11 43.4 2.4 0.031 14.2 0.2 5.6 5 0 0 5 5 5 4 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 ETO06124.1 - 4.4e-11 42.9 0.1 0.0066 16.7 0.0 5.0 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06124.1 - 2.9e-10 39.7 0.2 0.024 13.6 0.0 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO06124.1 - 2.9e-07 30.5 0.6 1.4e-05 25.1 0.0 3.1 2 2 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO06124.1 - 0.00039 19.9 0.5 2.8 7.2 0.0 3.3 1 1 2 3 3 3 3 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO06124.1 - 0.037 13.6 0.0 0.54 9.8 0.0 2.3 1 1 1 2 2 2 0 PQQ-like domain Proteasome_A_N PF10584.9 ETO06124.1 - 0.046 13.4 3.9 33 4.3 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF3843 PF12954.7 ETO06125.1 - 0.0014 17.7 0.4 0.0014 17.7 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3843) ALMT PF11744.8 ETO06125.1 - 0.03 13.2 7.2 0.034 13.0 7.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO06125.1 - 0.7 8.6 3.8 0.88 8.3 3.8 1.1 1 0 0 1 1 1 0 Presenilin TPR_12 PF13424.6 ETO06126.1 - 3.6e-44 148.9 0.9 1e-19 70.5 0.3 4.2 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06126.1 - 4.1e-34 115.5 0.1 5.5e-09 35.6 0.0 5.7 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06126.1 - 3.1e-26 90.1 38.6 1.6e-08 34.0 0.9 6.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06126.1 - 1.8e-25 87.0 7.9 2e-05 24.3 0.0 6.1 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06126.1 - 1.1e-23 81.3 34.2 6.6e-06 25.9 1.6 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06126.1 - 1.8e-20 71.3 26.8 3.6e-05 23.5 0.2 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06126.1 - 3.1e-11 43.7 0.0 0.00049 20.7 0.0 4.4 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO06126.1 - 4.1e-10 39.3 8.2 0.00054 20.2 0.1 5.8 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO06126.1 - 7e-07 29.1 14.9 0.002 18.1 0.3 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO06126.1 - 4.1e-06 26.9 2.6 0.018 15.3 0.2 3.8 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETO06126.1 - 2.2e-05 24.0 28.9 0.0014 18.3 4.3 6.6 5 1 1 6 6 6 2 TPR repeat TPR_6 PF13174.6 ETO06126.1 - 5.3e-05 23.6 10.1 4.1 8.2 0.2 5.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO06126.1 - 5.4e-05 23.7 0.0 3.5 8.7 0.0 5.0 5 1 1 6 6 5 1 Tetratricopeptide repeat TSR PF18487.1 ETO06126.1 - 0.00081 19.6 0.3 0.0025 18.0 0.3 1.8 1 0 0 1 1 1 1 Thrombospondin type 1 repeat DUF5113 PF17140.4 ETO06126.1 - 0.0036 17.1 15.2 0.72 9.6 0.4 4.4 4 1 1 5 5 5 3 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO06126.1 - 0.032 14.7 0.1 2.9 8.5 0.0 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat DUF4810 PF16068.5 ETO06126.1 - 3.4 8.3 12.5 6.8 7.3 0.1 5.0 4 1 2 6 6 6 0 Domain of unknown function (DUF4810) DSPc PF00782.20 ETO06128.1 - 4.9e-08 32.9 0.1 7.2e-08 32.3 0.1 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO06128.1 - 1.3e-05 24.9 0.0 1.6e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ETO06128.1 - 0.0035 17.4 0.4 0.0049 16.9 0.4 1.3 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ETO06128.1 - 0.013 15.6 0.1 0.017 15.2 0.1 1.3 1 1 0 1 1 1 0 Inositol hexakisphosphate Connexin PF00029.19 ETO06130.1 - 0.45 10.3 8.5 0.1 12.4 5.5 1.5 1 1 0 1 1 1 0 Connexin WD40 PF00400.32 ETO06131.1 - 2.7e-32 110.3 25.0 1.9e-05 25.3 0.3 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06131.1 - 3.4e-13 49.7 4.4 0.017 15.4 0.0 5.9 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06131.1 - 2.2e-09 36.5 6.2 0.03 13.0 0.0 4.9 3 2 2 5 5 5 4 Nucleoporin Nup120/160 F-box-like PF12937.7 ETO06132.1 - 0.0055 16.6 0.2 0.024 14.5 0.2 2.2 2 0 0 2 2 2 1 F-box-like FANCL_C PF11793.8 ETO06132.1 - 0.019 15.1 0.1 0.049 13.8 0.1 1.7 1 0 0 1 1 1 0 FANCL C-terminal domain WD40 PF00400.32 ETO06133.1 - 2.6e-31 107.2 18.5 1.1e-06 29.3 0.2 7.0 6 1 1 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO06133.1 - 1.6e-09 37.0 2.1 0.13 10.9 0.2 4.9 3 2 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06133.1 - 1.7e-05 25.1 0.1 0.27 11.6 0.0 4.5 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06133.1 - 0.0012 18.2 5.3 0.031 13.6 0.2 3.5 2 2 1 3 3 3 2 WD40-like domain Lig_C PF18330.1 ETO06134.1 - 0.0079 16.2 1.1 5.7 7.0 0.1 3.8 3 0 0 3 3 3 2 Ligase Pab1020 C-terminal region SapA PF02199.15 ETO06135.1 - 4.3 7.7 9.1 0.82 10.0 0.9 2.9 2 1 1 3 3 3 0 Saposin A-type domain WD40 PF00400.32 ETO06137.1 - 3.8e-10 40.2 3.3 1.9e-09 38.0 0.6 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO06137.1 - 0.0023 16.7 0.5 0.0032 16.2 0.4 1.2 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06137.1 - 0.0027 17.9 0.2 0.038 14.3 0.0 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain TPR_1 PF00515.28 ETO06138.1 - 3.6e-68 222.8 70.8 2e-07 30.6 0.1 19.0 19 0 0 19 19 19 13 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06138.1 - 3.3e-67 217.3 61.8 2.9e-06 27.0 0.1 19.1 18 1 1 19 19 19 14 Tetratricopeptide repeat TPR_19 PF14559.6 ETO06138.1 - 3.5e-66 219.6 29.5 2e-09 37.8 0.1 12.1 5 5 7 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06138.1 - 9.5e-62 200.1 55.7 1.1e-06 28.4 0.0 18.4 19 0 0 19 19 19 14 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06138.1 - 3.7e-58 193.9 8.3 2.4e-07 31.3 0.0 11.2 9 3 1 10 10 10 9 Tetratricopeptide repeat TPR_14 PF13428.6 ETO06138.1 - 2.5e-56 183.5 28.3 0.00012 22.6 0.2 18.2 5 4 14 19 19 19 14 Tetratricopeptide repeat TPR_12 PF13424.6 ETO06138.1 - 2e-47 159.3 35.0 3e-07 30.6 0.1 13.3 7 5 6 13 13 13 12 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06138.1 - 3.5e-46 151.9 19.0 0.00012 21.8 0.0 16.2 17 0 0 17 17 17 9 Tetratricopeptide repeat TPR_17 PF13431.6 ETO06138.1 - 2.8e-43 143.2 33.0 0.00062 20.0 0.3 16.1 17 3 0 17 17 15 8 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06138.1 - 2.1e-32 110.5 46.7 7.3e-06 25.6 0.5 14.2 13 4 4 17 17 15 9 TPR repeat TPR_6 PF13174.6 ETO06138.1 - 1.4e-27 94.4 39.2 0.19 12.4 0.0 16.3 17 0 0 17 17 16 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06138.1 - 5.7e-21 73.7 31.5 0.2 11.6 0.1 15.1 15 0 0 15 15 15 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO06138.1 - 2.8e-17 62.7 25.6 0.021 15.1 0.0 8.6 3 2 4 8 8 8 6 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETO06138.1 - 6.7e-17 61.6 28.2 0.0018 18.5 0.4 10.2 5 3 5 10 10 10 5 Tetratricopeptide repeat TPR_9 PF13371.6 ETO06138.1 - 2.4e-15 56.4 1.3 0.0018 18.4 0.0 7.7 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_4 PF07721.14 ETO06138.1 - 2.2e-13 49.5 0.0 11 7.0 0.0 11.6 14 0 0 14 14 11 0 Tetratricopeptide repeat NARP1 PF12569.8 ETO06138.1 - 3.1e-13 49.5 25.5 0.0088 15.0 7.9 6.7 1 1 4 6 6 6 4 NMDA receptor-regulated protein 1 TPR_MalT PF17874.1 ETO06138.1 - 4.9e-13 49.2 9.4 0.046 13.1 0.1 8.5 2 2 6 8 8 8 4 MalT-like TPR region FAT PF02259.23 ETO06138.1 - 8.9e-13 48.2 8.5 0.53 9.4 0.0 9.5 1 1 7 8 8 8 4 FAT domain TPR_21 PF09976.9 ETO06138.1 - 1.7e-11 44.2 26.8 0.00012 21.9 1.6 7.2 2 2 6 8 8 8 2 Tetratricopeptide repeat-like domain DUF4248 PF14053.6 ETO06138.1 - 2.2e-06 27.6 1.2 2.4 8.2 0.0 7.0 6 2 2 8 8 7 1 Domain of unknown function (DUF4248) Alkyl_sulf_dimr PF14863.6 ETO06138.1 - 3.1e-06 27.7 15.9 4.2 7.8 0.0 8.1 5 2 5 11 11 10 2 Alkyl sulfatase dimerisation TOM20_plant PF06552.12 ETO06138.1 - 3.3e-06 27.0 18.2 1.2 8.9 0.0 9.4 3 3 3 9 9 9 1 Plant specific mitochondrial import receptor subunit TOM20 TPR_15 PF13429.6 ETO06138.1 - 3.4e-06 26.5 16.0 0.35 10.0 0.9 7.6 1 1 6 8 8 8 3 Tetratricopeptide repeat PPR PF01535.20 ETO06138.1 - 0.00028 20.9 14.5 8.2 6.9 0.1 8.2 8 0 0 8 8 7 0 PPR repeat DUF2321 PF10083.9 ETO06138.1 - 0.0029 17.3 3.8 4.3 6.9 0.1 5.9 4 3 3 8 8 7 1 Uncharacterized protein conserved in bacteria (DUF2321) MazG PF03819.17 ETO06138.1 - 0.0073 16.5 1.0 13 6.1 0.0 5.2 5 0 0 5 5 5 0 MazG nucleotide pyrophosphohydrolase domain Glycoprot_B_PH2 PF17417.2 ETO06138.1 - 0.017 15.4 1.3 32 5.0 0.0 5.0 4 2 2 6 6 5 0 Herpesvirus Glycoprotein B PH-like domain YfiO PF13525.6 ETO06138.1 - 0.017 14.8 6.5 1.4 8.6 0.1 5.1 3 2 2 5 5 5 0 Outer membrane lipoprotein DUF2508 PF10704.9 ETO06138.1 - 0.044 14.0 12.2 1.1 9.5 2.1 5.6 5 1 1 6 6 5 0 Protein of unknown function (DUF2508) Endotoxin_C2 PF18449.1 ETO06138.1 - 0.081 13.3 1.5 13 6.2 0.1 3.3 3 0 0 3 3 2 0 Delta endotoxin Clathrin PF00637.20 ETO06138.1 - 0.17 11.7 26.5 0.55 10.1 2.3 6.0 4 3 0 4 4 4 0 Region in Clathrin and VPS Mad3_BUB1_I PF08311.12 ETO06138.1 - 3.6 7.6 15.4 27 4.8 0.1 6.7 8 0 0 8 8 7 0 Mad3/BUB1 homology region 1 DUF4810 PF16068.5 ETO06138.1 - 4.3 7.9 25.6 6.9 7.3 0.1 9.2 9 3 2 11 11 9 0 Domain of unknown function (DUF4810) Ank_2 PF12796.7 ETO06139.1 - 1.6e-27 95.9 4.8 3.5e-13 49.9 0.2 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO06139.1 - 1.7e-25 89.1 4.8 6.9e-08 32.9 0.1 5.2 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ETO06139.1 - 2.4e-25 87.8 2.5 0.00092 19.6 0.0 6.5 6 0 0 6 6 6 5 Ankyrin repeat Ank_3 PF13606.6 ETO06139.1 - 3.3e-21 73.1 4.3 0.0023 18.3 0.1 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ETO06139.1 - 7.8e-21 73.9 2.5 7.9e-07 29.2 0.1 5.5 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Sacchrp_dh_NADP PF03435.18 ETO06139.1 - 0.11 12.7 0.2 0.41 10.9 0.1 2.1 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain ResIII PF04851.15 ETO06140.1 - 0.28 11.2 0.0 0.28 11.2 0.0 3.9 4 1 0 4 4 4 0 Type III restriction enzyme, res subunit HrpB7 PF09486.10 ETO06140.1 - 3.6 8.0 12.5 0.69 10.3 1.9 2.8 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) Menin PF05053.13 ETO06141.1 - 1.1 7.5 12.3 1.1 7.5 12.3 1.0 1 0 0 1 1 1 0 Menin RGS12_usC PF16612.5 ETO06141.1 - 1.4 9.4 12.5 5.6 7.4 12.4 1.8 1 1 0 1 1 1 0 C-terminal unstructured region of RGS12 Herpes_LMP2 PF07415.11 ETO06141.1 - 7.6 5.2 6.0 8.6 5.0 6.0 1.0 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein WD40 PF00400.32 ETO06142.1 - 2.9e-28 97.5 16.6 1.8e-07 31.7 0.0 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO06142.1 - 3e-10 39.4 1.7 0.0019 16.9 0.1 4.0 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06142.1 - 1.3e-08 35.0 1.2 0.047 14.0 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06142.1 - 0.0015 17.9 3.1 0.099 12.0 0.6 2.9 2 1 2 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO06144.1 - 1.1e-48 162.2 10.8 8.4e-10 39.1 0.0 6.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06144.1 - 8.6e-23 80.5 0.3 0.00037 20.7 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06144.1 - 3.9e-12 46.1 1.7 0.0021 17.4 0.1 3.9 3 1 1 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO06144.1 - 1.5e-11 43.9 0.1 0.033 13.2 0.0 5.1 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06144.1 - 5.3e-09 35.3 1.2 0.24 10.0 0.0 4.9 1 1 2 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO06144.1 - 2.6e-07 30.4 3.8 1.8 8.6 0.0 6.6 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO06144.1 - 6.6e-05 21.6 0.1 0.52 8.8 0.0 2.9 1 1 1 3 3 3 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO06144.1 - 0.00045 19.1 2.6 0.74 8.5 0.1 3.5 1 1 3 4 4 4 2 Nup133 N terminal like DUF5570 PF17731.1 ETO06144.1 - 0.00059 19.9 0.0 11 6.1 0.0 3.6 2 1 2 4 4 4 2 Family of unknown function (DUF5570) Nop10p PF04135.12 ETO06144.1 - 0.00095 19.2 0.4 4.1 7.5 0.0 3.1 3 0 0 3 3 3 2 Nucleolar RNA-binding protein, Nop10p family PI3_PI4_kinase PF00454.27 ETO06145.1 - 3e-23 82.9 0.4 2.5e-20 73.4 0.4 2.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETO06145.1 - 6e-23 81.2 1.7 2.5e-22 79.2 0.2 2.1 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF226 PF02890.14 ETO06146.1 - 0.018 15.1 0.6 0.018 15.1 0.6 1.6 2 0 0 2 2 2 0 Borrelia family of unknown function DUF226 Kisspeptin PF15152.6 ETO06146.1 - 0.029 15.1 0.0 0.13 13.1 0.0 1.9 2 0 0 2 2 2 0 Kisspeptin BET PF17035.5 ETO06147.1 - 0.083 13.1 0.3 0.14 12.3 0.3 1.3 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation DUF1746 PF08508.10 ETO06148.1 - 0.029 14.7 1.4 2.1 8.7 0.0 2.5 2 1 0 2 2 2 0 Fungal domain of unknown function (DUF1746) TRM13 PF05206.14 ETO06149.1 - 2e-15 57.0 2.5 6.3e-08 32.5 0.4 3.1 1 1 2 3 3 3 3 Methyltransferase TRM13 Methyltransf_32 PF13679.6 ETO06149.1 - 0.0017 18.3 0.3 0.003 17.6 0.3 1.4 1 1 0 1 1 1 1 Methyltransferase domain HycI PF01750.18 ETO06149.1 - 0.16 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 Hydrogenase maturation protease Kelch_6 PF13964.6 ETO06150.1 - 0.00049 20.3 3.9 8.4 6.8 0.0 4.8 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO06150.1 - 0.0021 17.6 0.9 0.83 9.3 0.2 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO06150.1 - 0.016 15.1 1.1 5.8 7.0 0.1 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_3 PF13415.6 ETO06150.1 - 0.059 13.7 0.2 1.4 9.2 0.0 3.3 5 0 0 5 5 5 0 Galactose oxidase, central domain WD40 PF00400.32 ETO06151.1 - 1.9e-08 34.8 8.1 0.00025 21.8 0.4 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 ETO06153.1 - 3.6e-53 176.4 21.5 4.5e-09 36.8 0.0 9.1 10 0 0 10 10 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06153.1 - 8e-17 61.3 1.2 0.094 13.0 0.0 6.3 4 2 3 7 7 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06153.1 - 1.4e-10 41.1 9.3 0.00063 19.2 0.0 5.0 5 0 0 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO06153.1 - 4e-09 35.7 2.8 0.055 12.1 0.0 4.6 2 2 1 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO06153.1 - 8e-08 31.6 0.2 0.099 11.6 0.0 4.9 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_2 PF07646.15 ETO06153.1 - 3e-05 23.8 2.8 0.26 11.3 0.3 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO06153.1 - 8e-05 22.1 1.9 0.36 10.5 0.3 4.0 4 0 0 4 4 4 2 Kelch motif Cytochrom_D1 PF02239.16 ETO06153.1 - 0.00019 20.1 0.1 0.025 13.1 0.0 3.1 3 0 0 3 3 3 1 Cytochrome D1 heme domain Kelch_4 PF13418.6 ETO06153.1 - 0.00026 20.9 2.4 0.06 13.4 0.1 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Phage_CI_C PF16452.5 ETO06153.1 - 0.093 13.0 0.1 0.23 11.7 0.1 1.6 1 0 0 1 1 1 0 Bacteriophage CI repressor C-terminal domain PD40 PF07676.12 ETO06153.1 - 0.097 12.6 0.2 22 5.1 0.0 3.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO06154.1 - 4e-68 223.7 18.9 6e-10 39.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06154.1 - 7.2e-26 90.3 2.5 0.00016 21.9 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06154.1 - 7.6e-14 51.7 0.6 0.00074 18.9 0.1 4.2 2 1 1 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO06154.1 - 1.8e-13 50.2 2.1 0.0011 18.0 0.0 6.4 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06154.1 - 2.5e-11 43.0 3.3 0.4 9.3 0.0 5.6 2 1 4 6 6 6 5 Nucleoporin Nup120/160 PD40 PF07676.12 ETO06154.1 - 7.4e-06 25.8 6.5 4.8 7.2 0.0 6.0 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO06154.1 - 1.7e-05 24.9 0.6 0.54 10.4 0.1 4.7 2 1 2 4 4 4 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO06154.1 - 0.00027 20.6 0.3 0.031 13.9 0.3 3.5 1 1 0 1 1 1 1 PQQ-like domain DUF5474 PF17568.2 ETO06154.1 - 0.00055 19.9 0.5 0.74 9.9 0.1 3.6 2 1 2 4 4 4 1 Family of unknown function (DUF5474) Cytochrom_D1 PF02239.16 ETO06154.1 - 0.00068 18.3 0.1 0.0047 15.5 0.0 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain PQQ_3 PF13570.6 ETO06154.1 - 0.0057 17.1 0.3 1.4 9.5 0.0 3.5 3 0 0 3 3 2 1 PQQ-like domain PQQ PF01011.21 ETO06154.1 - 0.0063 16.4 0.0 1.3e+02 2.8 0.0 5.0 5 0 0 5 5 5 0 PQQ enzyme repeat ArlS_N PF18719.1 ETO06154.1 - 0.023 14.9 0.2 2.1 8.6 0.0 3.4 2 1 3 5 5 5 0 ArlS sensor domain Nbas_N PF15492.6 ETO06154.1 - 0.026 13.9 0.8 3.2 7.0 0.0 3.5 1 1 3 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO06154.1 - 0.035 13.8 3.1 73 3.2 0.1 4.9 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Utp8 PF10395.9 ETO06154.1 - 0.058 11.9 0.0 0.63 8.5 0.0 2.3 1 1 1 2 2 2 0 Utp8 family DUF2431 PF10354.9 ETO06154.1 - 0.13 12.5 0.1 27 5.0 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2431) Big_7 PF17957.1 ETO06154.1 - 1.1 10.0 4.0 2.8 8.8 0.0 3.5 5 1 0 5 5 5 0 Bacterial Ig domain Kelch_1 PF01344.25 ETO06155.1 - 1.7e-07 30.7 0.5 0.00032 20.2 0.1 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO06155.1 - 1.9e-06 28.0 3.7 0.25 11.7 0.1 4.3 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO06155.1 - 0.00011 22.0 3.2 0.53 10.3 0.1 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO06155.1 - 0.00015 21.7 1.7 0.35 10.9 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO06155.1 - 0.00026 20.9 0.3 0.024 14.6 0.1 3.3 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO06155.1 - 0.0032 17.7 0.4 0.027 14.8 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Methyltransf_FA PF12248.8 ETO06155.1 - 0.19 12.0 5.4 1.9 8.9 0.1 3.2 3 1 0 3 3 3 0 Farnesoic acid 0-methyl transferase Kelch_5 PF13854.6 ETO06156.1 - 0.00019 21.3 0.3 0.037 14.0 0.2 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO06156.1 - 0.00082 19.6 4.9 0.97 9.8 0.1 4.6 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO06156.1 - 0.002 18.1 0.2 0.044 13.8 0.1 3.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO06156.1 - 0.1 12.9 0.1 40 4.6 0.0 3.6 3 1 1 4 4 4 0 Galactose oxidase, central domain Helicase_C PF00271.31 ETO06157.1 - 1.9e-05 25.0 0.1 2.8e-05 24.4 0.1 1.3 1 0 0 1 1 1 1 Helicase conserved C-terminal domain XRN_N PF03159.18 ETO06158.1 - 5.8e-12 45.6 0.1 5.8e-12 45.6 0.1 2.5 2 1 0 2 2 1 1 XRN 5'-3' exonuclease N-terminus DAG_kinase_N PF14513.6 ETO06158.1 - 0.0032 17.7 8.0 0.0044 17.2 8.0 1.1 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus Mpp10 PF04006.12 ETO06158.1 - 0.0085 14.6 23.5 0.0099 14.4 23.5 1.1 1 0 0 1 1 1 1 Mpp10 protein CDC45 PF02724.14 ETO06158.1 - 0.016 13.6 22.1 0.021 13.2 22.1 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO06158.1 - 0.022 14.2 21.7 0.028 13.9 21.7 1.1 1 0 0 1 1 1 0 SDA1 GAGA_bind PF06217.12 ETO06158.1 - 0.03 14.6 7.1 0.034 14.4 7.1 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 ETO06158.1 - 0.044 12.5 12.4 0.051 12.3 12.4 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO06158.1 - 0.079 11.2 22.8 0.093 10.9 22.8 1.0 1 0 0 1 1 1 0 Nop14-like family CCDC106 PF15794.5 ETO06158.1 - 0.15 11.7 13.4 0.21 11.3 13.4 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 AAA_11 PF13086.6 ETO06158.1 - 0.18 11.5 8.3 0.23 11.2 8.3 1.2 1 0 0 1 1 1 0 AAA domain SLC12 PF03522.15 ETO06158.1 - 0.25 10.3 16.1 0.31 10.0 16.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Menin PF05053.13 ETO06158.1 - 0.35 9.2 10.1 0.43 8.9 10.1 1.2 1 0 0 1 1 1 0 Menin DUF2201_N PF13203.6 ETO06158.1 - 0.77 9.3 7.8 1 8.9 7.8 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain SAPS PF04499.15 ETO06158.1 - 1.2 7.9 15.5 1.4 7.6 15.5 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 ETO06158.1 - 1.2 9.2 6.0 1.5 8.8 6.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO06158.1 - 2.1 7.5 9.2 2.4 7.3 9.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 ETO06158.1 - 3.9 6.2 9.4 4.8 5.9 9.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 ETO06158.1 - 4.3 5.3 11.9 4.9 5.1 11.9 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRN3 PF05327.11 ETO06158.1 - 4.6 5.7 17.5 5.7 5.4 17.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 rRNA_processing PF08524.11 ETO06158.1 - 8.3 6.4 27.1 21 5.1 27.1 1.6 1 1 0 1 1 1 0 rRNA processing Nop25 PF09805.9 ETO06158.1 - 9 6.8 29.2 2e+03 -0.9 29.2 2.1 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) NTP_transf_2 PF01909.23 ETO06159.1 - 1.9e-09 37.7 1.4 1.3e-08 35.1 1.4 2.1 1 1 0 1 1 1 1 Nucleotidyltransferase domain PAP_assoc PF03828.19 ETO06159.1 - 1.9e-05 24.8 0.8 6.9e-05 23.0 0.1 2.3 2 1 0 2 2 2 1 Cid1 family poly A polymerase Polbeta PF18765.1 ETO06159.1 - 0.005 16.9 0.2 0.012 15.7 0.2 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase zf-rbx1 PF12678.7 ETO06160.1 - 6.7e-12 45.5 13.0 6.7e-12 45.5 13.0 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO06160.1 - 8.4e-08 32.2 6.0 8.4e-08 32.2 6.0 2.7 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_2 PF13639.6 ETO06160.1 - 0.00028 21.2 15.8 0.00028 21.2 15.8 2.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO06160.1 - 0.00091 19.0 7.8 0.00091 19.0 7.8 3.3 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-P11 PF03854.14 ETO06160.1 - 2 8.1 11.9 0.43 10.3 7.4 2.3 1 1 1 2 2 2 0 P-11 zinc finger PHD PF00628.29 ETO06160.1 - 8.9 6.3 19.6 1.4e+02 2.5 15.0 3.5 2 1 1 3 3 3 0 PHD-finger RRM_1 PF00076.22 ETO06162.1 - 0.012 15.4 0.1 0.038 13.8 0.1 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-C3H1 PF10650.9 ETO06162.1 - 0.031 14.0 6.5 0.26 11.0 1.0 2.7 2 0 0 2 2 2 0 Putative zinc-finger domain zf-CCCH_2 PF14608.6 ETO06162.1 - 1.5 9.4 11.7 11 6.7 1.1 2.9 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger Ras PF00071.22 ETO06163.1 - 2.7e-48 163.6 0.0 3.5e-48 163.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO06163.1 - 3.6e-24 85.3 0.0 1e-23 83.8 0.0 1.8 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO06163.1 - 4.8e-07 29.4 0.0 7.2e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO06163.1 - 0.0021 17.6 0.0 0.0032 17.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Hormone_6 PF00236.18 ETO06164.1 - 0.0036 17.2 0.6 0.0071 16.3 0.6 1.5 1 0 0 1 1 1 1 Glycoprotein hormone CAC1F_C PF16885.5 ETO06164.1 - 0.086 12.5 2.3 0.096 12.3 2.3 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LicD PF04991.13 ETO06164.1 - 0.89 9.6 5.9 1.1 9.4 5.9 1.1 1 0 0 1 1 1 0 LicD family FAM76 PF16046.5 ETO06166.1 - 9.6 5.5 20.7 16 4.8 20.7 1.3 1 0 0 1 1 1 0 FAM76 protein Exo_endo_phos_2 PF14529.6 ETO06167.1 - 1.6e-05 24.7 0.3 2.4e-05 24.2 0.3 1.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase V_ATPase_I PF01496.19 ETO06169.1 - 3.3e-25 88.2 2.4 1.7e-14 52.8 0.2 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family LRR19-TM PF15176.6 ETO06169.1 - 0.0093 16.0 0.0 0.011 15.7 0.0 1.1 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain NAD_binding_10 PF13460.6 ETO06172.1 - 1.7e-05 24.8 0.1 0.00014 21.8 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETO06172.1 - 4.5e-05 23.0 0.0 5.2e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Semialdhyde_dh PF01118.24 ETO06172.1 - 4.5e-05 23.9 0.1 0.0001 22.7 0.1 1.6 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 ETO06172.1 - 4.9e-05 22.6 0.1 9e-05 21.7 0.1 1.5 1 1 1 2 2 2 1 Polysaccharide biosynthesis protein ApbA PF02558.16 ETO06172.1 - 0.0016 18.1 0.0 0.0034 17.0 0.0 1.7 1 1 1 2 2 2 1 Ketopantoate reductase PanE/ApbA KR PF08659.10 ETO06172.1 - 0.0039 17.1 0.0 0.0047 16.8 0.0 1.1 1 0 0 1 1 1 1 KR domain 3Beta_HSD PF01073.19 ETO06172.1 - 0.0047 16.0 0.1 0.0056 15.7 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 ETO06172.1 - 0.013 15.6 0.2 0.02 15.0 0.2 1.4 1 1 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus GDP_Man_Dehyd PF16363.5 ETO06172.1 - 0.014 14.8 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Shikimate_DH PF01488.20 ETO06172.1 - 0.022 14.9 0.1 0.055 13.5 0.1 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ETO06172.1 - 0.048 13.9 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain NmrA PF05368.13 ETO06172.1 - 0.06 12.9 0.1 0.07 12.7 0.1 1.1 1 0 0 1 1 1 0 NmrA-like family Nucleoside_tran PF01733.18 ETO06172.1 - 0.077 12.4 0.2 0.095 12.1 0.2 1.1 1 0 0 1 1 1 0 Nucleoside transporter NAD_binding_4 PF07993.12 ETO06172.1 - 0.094 11.9 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Male sterility protein GARS_N PF02844.15 ETO06172.1 - 0.15 12.8 0.0 0.28 12.0 0.0 1.5 1 1 0 1 1 1 0 Phosphoribosylglycinamide synthetase, N domain RdRP PF05183.12 ETO06173.1 - 1.8e-61 208.5 0.1 7.1e-61 206.6 0.0 1.8 2 0 0 2 2 2 1 RNA dependent RNA polymerase DUF445 PF04286.12 ETO06173.1 - 0.098 12.4 0.4 0.17 11.6 0.3 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF445) RdRP PF05183.12 ETO06174.1 - 1.3e-14 53.8 0.1 1.3e-14 53.8 0.1 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase RdRP PF05183.12 ETO06175.1 - 1.5e-18 66.8 0.8 5.6e-18 64.9 0.8 1.7 1 1 0 1 1 1 1 RNA dependent RNA polymerase ETRAMP PF09716.10 ETO06175.1 - 0.6 10.2 8.2 4.9 7.3 8.2 2.1 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO06176.1 - 6.6e-40 134.4 9.2 1.5e-07 32.0 0.0 5.0 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06176.1 - 2.7e-08 34.0 0.4 0.0039 17.5 0.0 4.0 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06176.1 - 3.5e-06 26.2 0.2 1.3 7.9 0.0 4.4 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06176.1 - 3.6e-05 22.6 4.4 0.94 8.0 0.0 4.0 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06176.1 - 0.0023 17.3 0.1 0.11 11.8 0.1 2.4 1 1 2 3 3 3 3 WD40-like domain Nucleoporin_N PF08801.11 ETO06176.1 - 0.0089 14.8 2.0 0.5 9.0 0.1 2.9 1 1 1 3 3 3 1 Nup133 N terminal like DUF5570 PF17731.1 ETO06176.1 - 0.042 14.0 0.4 0.63 10.1 0.1 2.7 1 1 0 2 2 2 0 Family of unknown function (DUF5570) RT_RNaseH_2 PF17919.1 ETO06177.1 - 9e-34 115.5 0.4 1.3e-33 114.9 0.4 1.3 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETO06177.1 - 2e-28 98.7 0.3 3.9e-28 97.8 0.3 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase WD40 PF00400.32 ETO06178.1 - 3.3e-16 59.4 13.1 1.2e-05 26.0 1.0 4.5 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06178.1 - 1.3e-06 28.6 0.3 0.05 13.9 0.1 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06178.1 - 0.00095 17.9 0.2 0.027 13.1 0.1 2.0 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Kelch_1 PF01344.25 ETO06179.1 - 2.4e-05 23.8 0.5 0.0018 17.8 0.3 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO06179.1 - 0.00016 21.9 0.3 0.24 11.8 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO06179.1 - 0.0023 17.9 0.0 0.44 10.6 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06179.1 - 0.012 15.6 1.0 19 5.5 0.7 3.9 3 1 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO06179.1 - 0.016 15.4 0.0 0.31 11.4 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF1475 PF07343.11 ETO06179.1 - 0.08 12.7 0.9 11 5.7 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1475) TRAP_alpha PF03896.16 ETO06182.1 - 0.00027 20.3 0.3 0.00029 20.2 0.3 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit U1snRNP70_N PF12220.8 ETO06182.1 - 0.0026 18.4 3.4 0.0039 17.8 3.4 1.2 1 0 0 1 1 1 1 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RPN2_C PF18004.1 ETO06182.1 - 0.014 15.3 5.3 0.016 15.1 5.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain RNA_pol_3_Rpc31 PF11705.8 ETO06182.1 - 0.014 15.6 7.1 0.017 15.4 7.1 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Connexin PF00029.19 ETO06182.1 - 0.015 15.1 0.2 0.015 15.0 0.2 1.1 1 0 0 1 1 1 0 Connexin Myc_N PF01056.18 ETO06182.1 - 0.04 13.8 2.6 0.045 13.6 2.6 1.1 1 0 0 1 1 1 0 Myc amino-terminal region MscS_TM PF12794.7 ETO06182.1 - 0.046 12.6 1.4 0.059 12.2 1.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Orf78 PF06024.12 ETO06182.1 - 0.047 14.0 0.1 0.066 13.5 0.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Ferlin_C PF16165.5 ETO06182.1 - 0.051 13.5 2.3 0.078 12.9 2.3 1.4 1 0 0 1 1 1 0 Ferlin C-terminus EMC3_TMCO1 PF01956.16 ETO06182.1 - 0.054 13.2 0.5 0.091 12.5 0.5 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like V_ATPase_I PF01496.19 ETO06182.1 - 0.084 10.8 0.2 0.081 10.8 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TRAP-gamma PF07074.12 ETO06182.1 - 0.084 12.4 0.5 0.11 12.0 0.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) DUF3464 PF11947.8 ETO06182.1 - 0.11 12.2 0.6 0.15 11.8 0.6 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF1129 PF06570.11 ETO06182.1 - 0.12 11.8 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) DcuA_DcuB PF03605.14 ETO06182.1 - 0.13 11.1 0.1 0.16 10.8 0.1 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter RNA_polI_A34 PF08208.11 ETO06182.1 - 0.14 12.2 9.8 0.18 11.9 9.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 ORC_WH_C PF18137.1 ETO06182.1 - 0.23 11.5 4.9 0.31 11.1 4.9 1.1 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal TFB6 PF17110.5 ETO06182.1 - 0.51 10.1 4.5 0.65 9.7 4.5 1.1 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Tim54 PF11711.8 ETO06182.1 - 0.69 8.6 5.6 0.83 8.4 5.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4820 PF16091.5 ETO06182.1 - 1.1 8.5 4.4 1.4 8.2 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PBP_sp32 PF07222.12 ETO06182.1 - 1.6 8.1 9.8 2.2 7.7 9.8 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Radial_spoke PF04712.12 ETO06182.1 - 6.5 5.6 11.3 8.2 5.2 11.3 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Rad50_zn_hook PF04423.14 ETO06184.1 - 0.066 13.1 0.2 0.17 11.7 0.1 1.8 1 1 1 2 2 2 0 Rad50 zinc hook motif Ribosomal_S30AE PF02482.19 ETO06184.1 - 0.068 14.0 0.0 0.11 13.2 0.0 1.3 1 0 0 1 1 1 0 Sigma 54 modulation protein / S30EA ribosomal protein Ion_trans PF00520.31 ETO06185.1 - 4.2e-09 36.0 1.4 1.2e-07 31.3 3.7 1.9 2 0 0 2 2 2 1 Ion transport protein Zip PF02535.22 ETO06185.1 - 0.002 17.4 0.1 0.0031 16.8 0.0 1.3 2 0 0 2 2 2 1 ZIP Zinc transporter PhoLip_ATPase_C PF16212.5 ETO06185.1 - 0.014 15.2 1.0 0.021 14.6 1.0 1.3 1 1 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal Nop53 PF07767.11 ETO06185.1 - 3 7.1 19.6 3.9 6.8 19.6 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Lig_chan PF00060.26 ETO06186.1 - 2.2 8.1 4.4 0.99 9.2 0.0 2.6 3 0 0 3 3 3 0 Ligand-gated ion channel WD40 PF00400.32 ETO06187.1 - 6.5e-51 169.2 16.9 1.6e-09 38.2 1.1 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06187.1 - 5.5e-13 49.0 1.5 0.07 13.4 0.0 5.6 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide PF00805.22 ETO06187.1 - 1.8e-09 37.1 0.7 4.6e-09 35.7 0.7 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Ge1_WD40 PF16529.5 ETO06187.1 - 2.2e-08 33.4 0.7 0.43 9.5 0.0 5.3 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06187.1 - 7.3e-08 31.5 7.2 0.64 8.6 0.1 5.5 2 2 2 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06187.1 - 3.4e-06 26.6 2.4 0.02 14.2 0.1 3.1 2 1 1 3 3 3 2 WD40-like domain Pentapeptide_4 PF13599.6 ETO06187.1 - 0.0001 22.4 0.1 0.00023 21.3 0.1 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO06187.1 - 0.00013 22.0 6.4 0.0064 16.6 0.7 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO06187.1 - 0.00045 18.9 0.7 0.73 8.3 0.0 2.9 1 1 0 3 3 3 2 Cytochrome D1 heme domain SGL PF08450.12 ETO06187.1 - 0.034 13.7 0.2 0.27 10.8 0.2 2.6 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 ETO06187.1 - 0.034 14.3 0.2 18 5.6 0.0 3.8 3 1 1 4 4 4 0 Strictosidine synthase VID27 PF08553.10 ETO06187.1 - 0.082 12.0 0.0 1.9 7.5 0.0 2.5 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain Roc PF08477.13 ETO06187.1 - 0.087 13.1 3.0 14 6.0 0.0 4.0 2 2 3 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase PD40 PF07676.12 ETO06187.1 - 0.22 11.5 1.9 15 5.7 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DNA_pol_phi PF04931.13 ETO06188.1 - 3e-06 25.7 19.5 3.9e-06 25.3 19.5 1.2 1 0 0 1 1 1 1 DNA polymerase phi Nop14 PF04147.12 ETO06188.1 - 6.4e-05 21.4 17.2 6.9e-05 21.3 17.2 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO06188.1 - 0.0002 20.9 17.4 0.00024 20.6 17.4 1.1 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 ETO06188.1 - 0.00026 19.4 13.4 0.00031 19.2 13.4 1.1 1 0 0 1 1 1 1 CDC45-like protein RNA_pol_3_Rpc31 PF11705.8 ETO06188.1 - 0.00091 19.5 19.8 0.0015 18.9 19.8 1.4 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 LAP1C PF05609.12 ETO06188.1 - 0.0039 16.4 6.8 0.0043 16.2 6.8 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Drc1-Sld2 PF11719.8 ETO06188.1 - 0.008 15.8 9.9 0.0089 15.6 9.9 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein Mpp10 PF04006.12 ETO06188.1 - 0.0098 14.4 20.8 0.012 14.1 20.8 1.1 1 0 0 1 1 1 1 Mpp10 protein Prothymosin PF03247.14 ETO06188.1 - 0.011 16.2 41.9 0.019 15.4 41.9 1.3 1 0 0 1 1 1 0 Prothymosin/parathymosin family Hid1 PF12722.7 ETO06188.1 - 0.011 13.9 6.4 0.014 13.5 6.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 ETO06188.1 - 0.022 14.1 17.1 0.029 13.7 17.1 1.2 1 0 0 1 1 1 0 BUD22 CPSF100_C PF13299.6 ETO06188.1 - 0.03 14.5 5.1 0.048 13.9 5.1 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 ETO06188.1 - 0.061 13.2 7.9 0.085 12.7 7.9 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 ETO06188.1 - 0.073 13.6 7.3 0.15 12.5 7.3 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 ETO06188.1 - 0.089 12.5 1.4 0.14 11.9 1.4 1.3 1 0 0 1 1 1 0 Connexin CLN3 PF02487.17 ETO06188.1 - 0.11 11.5 0.5 0.17 10.9 0.2 1.4 2 0 0 2 2 2 0 CLN3 protein RNA_pol_Rpc4 PF05132.14 ETO06188.1 - 0.12 12.8 5.8 0.21 12.0 5.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF5523 PF17661.1 ETO06188.1 - 0.13 11.9 17.9 0.21 11.2 17.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) TFB6 PF17110.5 ETO06188.1 - 0.17 11.6 9.6 0.27 11.0 9.6 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH SspB PF04386.13 ETO06188.1 - 0.17 11.8 7.8 0.29 11.0 7.8 1.5 1 0 0 1 1 1 0 Stringent starvation protein B Serinc PF03348.15 ETO06188.1 - 0.22 10.4 2.1 0.41 9.5 2.1 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) O-antigen_lig PF13425.6 ETO06188.1 - 0.23 10.2 0.7 0.32 9.7 0.2 1.4 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF4637 PF15470.6 ETO06188.1 - 0.33 10.7 24.9 1.1 8.9 24.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4637) Zip PF02535.22 ETO06188.1 - 0.38 9.9 3.8 0.48 9.6 3.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PPP4R2 PF09184.11 ETO06188.1 - 0.6 9.7 21.4 0.09 12.4 17.3 1.8 2 0 0 2 2 2 0 PPP4R2 Presenilin PF01080.17 ETO06188.1 - 0.61 8.8 5.9 0.67 8.6 5.9 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO06188.1 - 0.62 8.4 4.1 0.74 8.1 4.1 1.1 1 0 0 1 1 1 0 Menin V_ATPase_I PF01496.19 ETO06188.1 - 0.69 7.8 6.2 0.96 7.3 6.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sporozoite_P67 PF05642.11 ETO06188.1 - 1 7.4 22.4 9.5 4.2 22.4 1.9 1 1 0 1 1 1 0 Sporozoite P67 surface antigen DUF913 PF06025.12 ETO06188.1 - 1.1 8.2 6.5 1.4 7.9 6.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Tim54 PF11711.8 ETO06188.1 - 1.2 7.8 9.9 1.9 7.2 9.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FYDLN_acid PF09538.10 ETO06188.1 - 1.4 9.6 20.8 3.1 8.5 20.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) XAP5 PF04921.14 ETO06188.1 - 1.7 8.4 10.1 2.6 7.8 10.1 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator Astro_capsid_p PF12226.8 ETO06188.1 - 2.3 7.3 19.9 3.7 6.6 19.9 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein PDDEXK_6 PF04720.12 ETO06188.1 - 2.5 8.0 7.2 3.9 7.4 7.2 1.5 1 0 0 1 1 1 0 PDDEXK-like family of unknown function NPR3 PF03666.13 ETO06188.1 - 3.1 6.5 9.3 4 6.1 9.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 ETO06188.1 - 3.7 6.8 26.1 5.3 6.3 26.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RRN3 PF05327.11 ETO06188.1 - 5.1 5.5 16.4 6.3 5.2 16.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 IFT57 PF10498.9 ETO06188.1 - 5.4 5.9 17.1 9.8 5.0 17.1 1.4 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 RPN2_C PF18004.1 ETO06188.1 - 6.8 6.6 15.7 12 5.8 15.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4746 PF15928.5 ETO06188.1 - 7.3 5.9 18.2 12 5.2 18.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FAM176 PF14851.6 ETO06188.1 - 8.1 6.1 26.2 11 5.6 15.7 2.4 1 1 1 2 2 2 0 FAM176 family HSP90 PF00183.18 ETO06188.1 - 9.6 5.0 19.5 14 4.4 19.5 1.1 1 0 0 1 1 1 0 Hsp90 protein Molybdop_Fe4S4 PF04879.16 ETO06189.1 - 0.22 11.6 2.9 0.32 11.0 1.3 2.1 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain mCpol PF18182.1 ETO06189.1 - 8.9 6.7 9.5 0.3 11.4 0.6 3.2 3 1 1 4 4 4 0 minimal CRISPR polymerase domain RNA_pol_Rpb5_C PF01191.19 ETO06192.1 - 4.7e-35 119.3 0.5 1.1e-34 118.1 0.5 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb5, C-terminal domain RNA_pol_Rpb5_N PF03871.14 ETO06192.1 - 1.3e-14 54.6 1.1 1.9e-14 54.0 0.3 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb5, N-terminal domain ATP_bind_3 PF01171.20 ETO06192.1 - 0.0017 18.1 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 PP-loop family Sof1 PF04158.14 ETO06192.1 - 0.045 14.0 0.4 0.1 12.8 0.4 1.6 1 0 0 1 1 1 0 Sof1-like domain Pathogen_betaC1 PF09593.10 ETO06192.1 - 0.31 11.0 3.6 0.27 11.2 1.7 1.8 1 1 1 2 2 2 0 Beta-satellite pathogenicity beta C1 protein SAM_1 PF00536.30 ETO06193.1 - 2.4e-07 31.1 1.1 5.1e-07 30.0 1.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO06193.1 - 0.0016 18.4 1.2 0.0064 16.4 0.2 2.5 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain Colicin_K PF17500.2 ETO06193.1 - 0.03 14.9 1.3 0.066 13.8 1.3 1.5 1 0 0 1 1 1 0 Colicin-K SAM_Ste50p PF09235.10 ETO06193.1 - 0.061 13.6 0.2 0.17 12.2 0.2 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif RGS PF00615.19 ETO06194.1 - 7.7e-05 22.9 0.2 9.8e-05 22.6 0.2 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain PhoPQ_related PF10142.9 ETO06194.1 - 0.071 11.8 0.2 0.088 11.4 0.2 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein WD40 PF00400.32 ETO06195.1 - 5.7e-24 83.9 1.0 1.1e-05 26.1 0.0 6.4 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06195.1 - 6.2e-13 48.9 0.2 0.00034 20.8 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO06195.1 - 1.6e-06 27.9 3.8 4.8 7.2 0.0 5.5 4 1 1 5 5 5 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO06195.1 - 0.0092 14.5 0.1 0.78 8.2 0.0 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF3892 PF13031.6 ETO06195.1 - 0.037 14.7 0.2 0.15 12.7 0.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3892) DPPIV_N PF00930.21 ETO06195.1 - 0.055 12.2 0.4 3.3 6.4 0.0 3.1 1 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Str_synth PF03088.16 ETO06195.1 - 0.065 13.4 0.2 13 5.9 0.0 3.3 3 0 0 3 3 3 0 Strictosidine synthase SGL PF08450.12 ETO06195.1 - 0.16 11.5 0.0 1.4 8.5 0.0 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Proteasome_A_N PF10584.9 ETO06195.1 - 0.61 9.8 9.1 15 5.4 0.1 4.8 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature EBA-175_VI PF11556.8 ETO06196.1 - 0.014 15.7 1.8 0.021 15.2 1.8 1.3 1 0 0 1 1 1 0 Erythrocyte binding antigen 175 zf-C3HC4_2 PF13923.6 ETO06196.1 - 0.23 11.3 5.3 1.9 8.4 0.0 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 ETO06197.1 - 1.3e-18 67.0 15.4 0.0004 21.1 1.3 6.2 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06197.1 - 2.9e-05 24.3 0.2 0.065 13.5 0.0 3.4 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain ATP13 PF12921.7 ETO06197.1 - 0.015 15.2 2.0 1.8 8.5 0.1 3.0 3 1 0 3 3 3 0 Mitochondrial ATPase expression Phage_Mu_Gam PF07352.12 ETO06198.1 - 0.0089 15.9 8.8 0.0089 15.9 8.8 3.2 2 2 1 3 3 3 1 Bacteriophage Mu Gam like protein Menin PF05053.13 ETO06198.1 - 0.011 14.1 17.0 0.016 13.6 17.0 1.2 1 0 0 1 1 1 0 Menin Filament PF00038.21 ETO06198.1 - 0.034 13.7 33.2 0.038 13.6 3.4 3.3 2 1 1 3 3 3 0 Intermediate filament protein Golgin_A5 PF09787.9 ETO06198.1 - 0.044 13.3 43.6 0.044 13.2 27.1 2.4 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF2353 PF09789.9 ETO06198.1 - 0.12 11.8 37.3 0.066 12.6 3.0 3.5 2 1 1 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) DUF3323 PF11796.8 ETO06198.1 - 0.23 11.3 9.9 0.16 11.8 5.0 2.1 2 0 0 2 2 2 0 Protein of unknown function N-terminus (DUF3323) CDT1_C PF16679.5 ETO06198.1 - 1.6 9.2 9.7 2.2 8.8 5.7 2.8 2 1 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain DUF489 PF04356.12 ETO06198.1 - 4.8 7.1 15.1 0.78 9.7 3.5 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF489) ASPRs PF17641.2 ETO06198.1 - 6.2 7.1 12.2 0.18 12.1 4.8 2.2 2 1 0 2 2 2 0 Ancylostoma-associated secreted protein related G-gamma PF00631.22 ETO06198.1 - 8.5 6.5 8.2 2.6 8.1 1.0 3.5 3 1 1 4 4 4 0 GGL domain Peptidase_S15 PF02129.18 ETO06201.1 - 4e-17 62.7 2.3 5e-13 49.2 1.6 2.4 1 1 1 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Metallophos PF00149.28 ETO06202.1 - 3.8e-18 66.7 3.6 8.8e-18 65.5 3.6 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ETO06202.1 - 6.4e-13 49.4 0.0 2.1e-12 47.7 0.0 2.0 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 ETO06202.1 - 1.8e-10 41.2 0.3 1.8e-10 41.2 0.3 2.0 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain PPDFL PF15060.6 ETO06203.1 - 0.24 11.9 4.7 0.083 13.4 0.9 2.1 1 1 1 2 2 2 0 Differentiation and proliferation regulator PVL_ORF50 PF07768.11 ETO06207.1 - 0.085 13.2 0.1 0.17 12.2 0.1 1.5 1 0 0 1 1 1 0 PVL ORF-50-like family DUF3677 PF12432.8 ETO06208.1 - 0.027 14.8 1.2 0.19 12.1 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3677) Pih1_fungal_CS PF18482.1 ETO06208.1 - 3.4 8.3 9.8 3.9 8.1 0.1 3.6 3 1 0 3 3 3 0 Fungal Pih1 CS domain Adenine_glyco PF03352.13 ETO06210.1 - 0.05 13.4 1.8 0.074 12.8 0.5 1.9 2 0 0 2 2 2 0 Methyladenine glycosylase ArAE_1_C PF11728.8 ETO06210.1 - 0.096 12.7 5.2 0.34 10.9 0.2 2.6 3 0 0 3 3 3 0 Putative aromatic acid exporter C-terminal domain PPR PF01535.20 ETO06212.1 - 1.7e-14 52.9 0.6 0.22 11.8 0.0 5.3 5 0 0 5 5 5 4 PPR repeat PPR_2 PF13041.6 ETO06212.1 - 4.7e-10 39.5 0.4 0.00046 20.3 0.0 4.5 2 1 3 5 5 5 4 PPR repeat family PPR_1 PF12854.7 ETO06212.1 - 1.3e-09 37.6 0.3 0.017 14.8 0.0 4.1 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 ETO06212.1 - 2.7e-05 24.2 0.0 0.059 13.5 0.0 3.6 2 1 0 3 3 3 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO06212.1 - 0.00046 19.6 0.0 0.007 15.8 0.0 2.2 1 1 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP RCC1 PF00415.18 ETO06213.1 - 2.1e-17 63.4 0.7 1.4e-08 35.2 0.0 4.6 5 1 1 6 6 6 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO06213.1 - 1.9e-07 30.7 1.1 0.00011 21.9 0.3 3.3 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat VIR_N PF15912.5 ETO06213.1 - 0.11 12.1 2.0 0.16 11.6 2.0 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal SET PF00856.28 ETO06214.1 - 1.4e-10 41.9 0.3 2.5e-10 41.0 0.2 1.5 1 1 0 1 1 1 1 SET domain CAP_GLY PF01302.25 ETO06215.1 - 1.6e-09 37.7 0.0 3.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain Ribosomal_L16 PF00252.18 ETO06217.1 - 1e-32 112.9 0.1 1.6e-32 112.2 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e PAP_central PF04928.17 ETO06218.1 - 4e-05 22.7 0.2 6.2e-05 22.1 0.2 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain Draxin PF15550.6 ETO06218.1 - 0.0029 17.5 2.0 0.0034 17.3 2.0 1.1 1 0 0 1 1 1 1 Draxin VPS28 PF03997.12 ETO06219.1 - 2.8e-59 200.0 0.2 3.4e-59 199.7 0.2 1.1 1 0 0 1 1 1 1 VPS28 protein NRD1_2 PF01995.16 ETO06219.1 - 0.07 12.4 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 NrpR regulatory domains NRD1 and 2 DUF4485 PF14846.6 ETO06219.1 - 0.088 12.9 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4485) tRNA-synt_1d PF00750.19 ETO06220.1 - 5.6e-31 107.8 0.4 9.7e-29 100.4 0.1 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (R) SUV3_C PF12513.8 ETO06220.1 - 0.12 12.3 0.1 0.4 10.6 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial degradasome RNA helicase subunit C terminal RGS12_us1 PF16613.5 ETO06223.1 - 0.099 13.0 0.3 0.099 13.0 0.3 2.5 2 1 0 3 3 3 0 Unstructured region of RGS12 Otopetrin PF03189.13 ETO06223.1 - 5.3 5.8 6.9 8.4 5.1 6.9 1.4 1 1 0 1 1 1 0 Otopetrin Ureide_permease PF07168.11 ETO06223.1 - 5.7 5.6 8.3 0.16 10.7 1.1 1.7 2 0 0 2 2 2 0 Ureide permease Peroxin-13_N PF04088.13 ETO06224.1 - 0.02 15.2 1.3 0.023 15.0 1.3 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Tim54 PF11711.8 ETO06224.1 - 0.034 12.9 1.2 0.04 12.7 1.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 UPF0239 PF06783.11 ETO06224.1 - 0.14 12.4 1.1 0.23 11.7 1.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Presenilin PF01080.17 ETO06224.1 - 0.18 10.5 1.4 0.17 10.6 1.4 1.2 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO06224.1 - 0.21 10.9 5.5 0.22 10.8 5.5 1.0 1 0 0 1 1 1 0 NOA36 protein Spo0A_C PF08769.11 ETO06225.1 - 0.12 12.5 5.9 0.21 11.7 0.1 3.1 2 1 1 3 3 3 0 Sporulation initiation factor Spo0A C terminal V-ATPase_H_N PF03224.14 ETO06226.1 - 0.00018 20.9 1.4 0.00034 20.0 1.4 1.4 1 0 0 1 1 1 1 V-ATPase subunit H Arm PF00514.23 ETO06226.1 - 0.3 11.2 1.0 40 4.5 0.0 3.5 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat MFS_2 PF13347.6 ETO06227.1 - 4.3e-08 32.2 1.1 9e-08 31.1 0.0 1.9 2 1 0 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.16 ETO06227.1 - 2.9e-07 29.8 4.0 6.1e-07 28.7 3.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily MHC_I_3 PF16497.5 ETO06228.1 - 0.036 13.6 0.0 0.055 12.9 0.0 1.4 1 0 0 1 1 1 0 MHC-I family domain Hormone_1 PF00103.20 ETO06228.1 - 0.27 10.9 5.0 0.49 10.1 5.0 1.3 1 1 0 1 1 1 0 Somatotropin hormone family NFACT-R_1 PF05670.13 ETO06229.1 - 2.1e-38 131.3 0.0 4.9e-38 130.1 0.0 1.7 1 0 0 1 1 1 1 NFACT protein RNA binding domain SPATIAL PF15256.6 ETO06229.1 - 0.13 12.5 5.7 0.19 12.0 5.7 1.2 1 0 0 1 1 1 0 SPATIAL RRM_1 PF00076.22 ETO06230.1 - 1.2e-17 63.5 0.1 3.6e-17 62.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO06230.1 - 0.014 15.0 0.0 0.033 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO06230.1 - 0.052 13.6 0.0 0.38 10.8 0.0 2.3 2 0 0 2 2 2 0 RNA binding domain H_lectin PF09458.10 ETO06231.1 - 0.043 14.0 1.2 1.4 9.2 0.0 2.8 3 0 0 3 3 3 0 H-type lectin domain TPR_12 PF13424.6 ETO06232.1 - 3.6e-11 43.2 0.1 1.2e-05 25.5 0.0 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06232.1 - 7e-08 32.1 1.5 0.00075 19.5 0.2 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06232.1 - 7.8e-06 25.6 0.0 0.0057 16.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06232.1 - 0.0003 20.5 0.5 0.06 13.2 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06232.1 - 0.016 15.3 0.8 5.3 7.4 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06232.1 - 0.025 14.3 1.5 7.7 6.3 0.0 3.4 2 1 1 3 3 3 0 TPR repeat Fer4_12 PF13353.6 ETO06232.1 - 0.034 14.4 0.2 0.098 12.9 0.1 2.0 2 1 0 2 2 2 0 4Fe-4S single cluster domain DUF1811 PF08838.10 ETO06232.1 - 0.15 12.3 1.0 0.52 10.6 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1811) RNA_pol_A_bac PF01000.26 ETO06232.1 - 3.5 8.0 5.7 13 6.2 0.7 3.3 2 2 2 4 4 4 0 RNA polymerase Rpb3/RpoA insert domain SAM_2 PF07647.17 ETO06233.1 - 0.00095 19.2 1.0 27 4.9 0.0 4.7 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO06233.1 - 0.0042 17.5 2.3 12 6.4 0.1 4.2 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) ZYG-11_interact PF05884.12 ETO06233.1 - 0.37 10.2 0.9 1.4 8.2 0.2 2.0 1 1 1 2 2 2 0 Interactor of ZYG-11 MttA_Hcf106 PF02416.16 ETO06233.1 - 1.1 8.6 3.6 16 4.9 0.0 2.9 2 0 0 2 2 2 0 mttA/Hcf106 family LRR_6 PF13516.6 ETO06234.1 - 1.6e-10 40.1 14.4 0.0061 16.5 0.1 7.1 6 0 0 6 6 6 3 Leucine Rich repeat LRR_4 PF12799.7 ETO06234.1 - 0.0049 17.3 15.6 1.9 9.0 0.0 6.5 6 0 0 6 6 6 1 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO06234.1 - 0.07 13.7 11.4 12 7.0 0.1 5.9 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 ETO06234.1 - 3.2 7.6 21.1 12 5.8 0.1 6.8 7 2 2 9 9 9 0 Leucine rich repeat CRAL_TRIO_2 PF13716.6 ETO06237.1 - 0.014 15.5 0.8 0.037 14.2 0.3 1.9 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain WD40 PF00400.32 ETO06239.1 - 6.4e-12 45.8 17.0 2.7e-05 24.8 0.2 5.0 3 2 1 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06239.1 - 0.058 13.7 0.3 0.22 11.8 0.0 2.2 2 2 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain LRR_4 PF12799.7 ETO06240.1 - 0.028 14.9 0.3 8.6 6.9 0.1 4.0 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) SDA1 PF05285.12 ETO06241.1 - 0.0024 17.4 25.2 0.0027 17.2 25.2 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO06241.1 - 0.41 8.8 27.8 0.53 8.4 27.8 1.2 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 ETO06241.1 - 0.56 9.4 6.6 0.63 9.2 6.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO06241.1 - 0.61 8.3 20.6 0.75 8.0 20.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 ETO06241.1 - 0.94 8.4 7.1 1.3 8.0 7.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 ETO06241.1 - 2.5 6.1 30.3 3.3 5.7 30.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi SpoIIIAH PF12685.7 ETO06241.1 - 3.5 7.4 19.7 4.5 7.0 19.7 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Raftlin PF15250.6 ETO06241.1 - 5 5.8 10.9 7.9 5.1 10.9 1.3 1 0 0 1 1 1 0 Raftlin DUF4746 PF15928.5 ETO06241.1 - 7 6.0 15.6 11 5.4 15.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PTPRCAP PF15713.5 ETO06241.1 - 9.2 6.5 18.4 16 5.7 18.4 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated WD40 PF00400.32 ETO06242.1 - 2.4e-38 129.4 30.7 4.2e-06 27.4 1.7 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06242.1 - 1.5e-10 41.3 2.9 0.42 11.0 0.1 6.0 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06242.1 - 4.9e-07 28.8 7.7 0.23 10.1 0.6 5.5 2 2 3 5 5 5 4 Nucleoporin Nup120/160 2OG-FeII_Oxy_3 PF13640.6 ETO06243.1 - 0.0054 17.6 0.0 0.013 16.3 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily NACHT PF05729.12 ETO06244.1 - 0.002 18.1 0.0 0.003 17.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO06244.1 - 0.0029 17.9 0.0 0.0064 16.8 0.0 1.6 1 1 0 1 1 1 1 AAA domain PRK PF00485.18 ETO06244.1 - 0.0031 17.3 0.0 0.005 16.6 0.0 1.5 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family TsaE PF02367.17 ETO06244.1 - 0.018 15.0 0.0 0.038 14.0 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_18 PF13238.6 ETO06244.1 - 0.018 15.6 2.9 0.031 14.8 0.4 2.5 1 1 1 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO06244.1 - 0.025 15.1 3.6 0.12 12.8 3.2 2.3 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ETO06244.1 - 0.027 14.9 1.7 0.25 11.7 0.1 2.6 2 1 0 2 2 2 0 RNA helicase AAA_33 PF13671.6 ETO06244.1 - 0.048 13.8 0.0 0.091 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATP_bind_2 PF03668.15 ETO06244.1 - 0.062 12.6 0.0 0.094 12.0 0.0 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family RsgA_GTPase PF03193.16 ETO06244.1 - 0.068 13.1 0.2 0.18 11.7 0.2 1.9 1 1 0 1 1 1 0 RsgA GTPase Med9 PF07544.13 ETO06244.1 - 0.54 10.4 5.7 0.57 10.3 0.1 2.9 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 RVT_1 PF00078.27 ETO06245.1 - 2.4e-22 79.5 0.0 5.5e-22 78.4 0.0 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Prefoldin PF02996.17 ETO06245.1 - 0.032 14.2 0.5 0.15 12.0 0.5 2.1 2 0 0 2 2 2 0 Prefoldin subunit zf-C2H2_4 PF13894.6 ETO06245.1 - 0.13 13.2 0.4 0.77 10.8 0.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger CENP-Q PF13094.6 ETO06245.1 - 0.15 12.3 10.1 0.12 12.6 6.9 2.4 2 0 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF745 PF05335.13 ETO06245.1 - 2.6 7.7 4.4 5.4 6.7 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF745) WD40 PF00400.32 ETO06246.1 - 1.1e-37 127.4 11.5 2.2e-08 34.6 0.1 5.7 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06246.1 - 2.4e-15 56.6 0.1 0.00012 22.3 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06246.1 - 8.9e-11 41.3 1.2 0.13 11.2 0.1 5.1 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO06246.1 - 9.6e-09 34.7 3.3 5e-05 22.8 0.1 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO06246.1 - 0.0012 18.7 1.4 4.8 7.2 0.0 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO06246.1 - 0.0013 18.2 1.2 2.2 7.5 0.0 3.7 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Pentapeptide_4 PF13599.6 ETO06246.1 - 0.0094 16.1 0.4 0.034 14.3 0.1 2.1 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO06246.1 - 0.051 13.7 0.9 0.12 12.5 0.6 1.8 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF3763 PF12592.8 ETO06246.1 - 0.21 11.7 2.5 4.4 7.4 0.4 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3763) Proteasome_A_N PF10584.9 ETO06246.1 - 3.3 7.5 4.7 42 3.9 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Pro_isomerase PF00160.21 ETO06247.1 - 1e-47 162.3 0.1 1.2e-47 162.2 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD NPR3 PF03666.13 ETO06248.1 - 0.18 10.5 3.7 0.19 10.5 3.7 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apolipoprotein PF01442.18 ETO06250.1 - 0.012 15.4 11.1 0.046 13.6 11.1 1.9 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Cob_adeno_trans PF01923.18 ETO06250.1 - 0.29 11.3 6.6 0.2 11.8 1.9 2.4 2 0 0 2 2 2 0 Cobalamin adenosyltransferase FliS PF02561.14 ETO06250.1 - 0.64 10.3 5.3 0.41 10.9 0.5 2.9 2 1 0 2 2 2 0 Flagellar protein FliS DUF948 PF06103.11 ETO06250.1 - 0.97 9.7 14.9 0.1 12.9 0.7 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF489 PF04356.12 ETO06250.1 - 1.4 8.9 9.2 8.4 6.3 0.1 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF489) DUF1664 PF07889.12 ETO06250.1 - 7.1 6.7 20.8 3.6 7.6 2.0 2.9 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Tctex-1 PF03645.13 ETO06251.1 - 2e-06 28.0 0.4 2e-06 28.0 0.4 2.5 2 1 1 3 3 3 1 Tctex-1 family CAP_GLY PF01302.25 ETO06252.1 - 2.9e-20 72.1 0.6 2.9e-20 72.1 0.6 1.9 2 0 0 2 2 2 1 CAP-Gly domain DivIC PF04977.15 ETO06252.1 - 0.58 10.0 31.9 0.2 11.4 5.6 4.3 2 1 2 4 4 4 0 Septum formation initiator FlaC_arch PF05377.11 ETO06252.1 - 1.3 9.5 19.7 7.2 7.1 3.1 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 ETO06252.1 - 1.7 8.7 27.3 4 7.5 21.8 2.8 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Spectrin PF00435.21 ETO06252.1 - 2.3 8.7 19.1 1.3 9.6 15.6 2.3 2 1 0 2 2 2 0 Spectrin repeat DUF2203 PF09969.9 ETO06252.1 - 2.4 8.9 13.5 6.7 7.5 10.5 2.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Spc7 PF08317.11 ETO06252.1 - 2.5 6.9 28.0 17 4.2 28.1 2.1 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4854 PF16146.5 ETO06252.1 - 2.5 8.5 8.9 2.1 8.7 7.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4854) Com_YlbF PF06133.11 ETO06252.1 - 3.6 8.3 24.1 16 6.2 0.2 2.4 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA LMBR1 PF04791.16 ETO06252.1 - 4.2 6.2 11.5 5.7 5.7 11.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein LapA_dom PF06305.11 ETO06252.1 - 4.2 7.3 13.2 3.9 7.4 0.3 3.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain MDH PF02315.16 ETO06252.1 - 7.7 6.7 6.3 24 5.1 2.2 2.4 1 1 1 2 2 2 0 Methanol dehydrogenase beta subunit ALMT PF11744.8 ETO06252.1 - 9.7 4.9 10.3 14 4.3 10.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4406 PF14359.6 ETO06253.1 - 0.031 14.8 0.2 0.046 14.2 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4406) DcuA_DcuB PF03605.14 ETO06253.1 - 0.14 11.0 0.3 0.14 11.0 0.3 1.0 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter EMC3_TMCO1 PF01956.16 ETO06253.1 - 5.6 6.7 9.3 6.3 6.5 9.3 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF2244 PF10003.9 ETO06254.1 - 0.023 14.4 0.2 0.048 13.3 0.2 1.5 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Tnp_P_element PF12017.8 ETO06256.1 - 0.14 11.6 5.7 0.16 11.4 5.7 1.0 1 0 0 1 1 1 0 Transposase protein Pkinase PF00069.25 ETO06257.1 - 1.2e-06 28.1 0.1 1.2e-06 28.1 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain ABC2_membrane_3 PF12698.7 ETO06257.1 - 0.12 11.4 7.5 0.15 11.1 3.9 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein DHHC PF01529.20 ETO06257.1 - 0.2 11.7 6.9 0.09 12.9 4.5 1.6 2 0 0 2 2 2 0 DHHC palmitoyltransferase MT-A70 PF05063.14 ETO06258.1 - 3.6e-38 131.2 0.0 5.6e-38 130.6 0.0 1.3 1 0 0 1 1 1 1 MT-A70 Presenilin PF01080.17 ETO06258.1 - 1.8 7.2 3.2 2.1 7.0 3.2 1.1 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO06258.1 - 5.8 5.1 6.6 7 4.9 6.6 1.1 1 0 0 1 1 1 0 Menin NPR3 PF03666.13 ETO06258.1 - 8.8 5.0 7.2 11 4.7 7.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 WD40 PF00400.32 ETO06259.1 - 1.3e-16 60.7 9.8 3.1e-05 24.7 0.5 4.1 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06259.1 - 6.9e-06 26.3 0.1 0.13 12.6 0.0 3.1 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06259.1 - 3.8e-05 22.5 0.8 1.2 7.7 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06259.1 - 0.00069 19.0 1.7 0.011 15.1 0.1 2.3 1 1 2 3 3 3 1 WD40-like domain DUF4979 PF16351.5 ETO06259.1 - 0.022 15.0 0.2 7.5 6.8 0.1 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) Nucleoporin_N PF08801.11 ETO06259.1 - 0.035 12.8 1.3 0.082 11.6 1.3 1.7 1 1 0 1 1 1 0 Nup133 N terminal like WD40 PF00400.32 ETO06260.1 - 1.3e-05 25.8 0.2 5.6e-05 23.8 0.1 2.1 3 1 0 3 3 3 1 WD domain, G-beta repeat DUF1921 PF09081.10 ETO06260.1 - 0.12 12.6 0.0 12 6.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1921) Secretin_N_2 PF07655.13 ETO06261.1 - 0.41 11.2 7.4 0.74 10.4 7.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Apis_Csd PF11671.8 ETO06261.1 - 0.51 10.4 7.9 0.71 9.9 7.9 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein Thr_synth_N PF14821.6 ETO06262.1 - 1e-18 67.3 0.0 1.5e-18 66.8 0.0 1.2 1 0 0 1 1 1 1 Threonine synthase N terminus CBFD_NFYB_HMF PF00808.23 ETO06262.1 - 0.14 12.5 0.0 0.66 10.3 0.0 1.9 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone BORCS6 PF10157.9 ETO06263.1 - 0.07 13.3 0.0 0.097 12.9 0.0 1.2 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Nbs1_C PF08599.10 ETO06264.1 - 0.7 10.1 10.6 29 4.9 0.6 4.3 4 0 0 4 4 4 0 DNA damage repair protein Nbs1 Sina PF03145.16 ETO06265.1 - 0.00032 20.7 0.9 0.00035 20.6 0.9 1.2 1 0 0 1 1 1 1 Seven in absentia protein family Ly49 PF08391.10 ETO06265.1 - 2.5 8.5 8.9 0.2 12.0 2.6 2.0 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region DUF5611 PF18446.1 ETO06266.1 - 0.034 15.0 0.5 9.6 7.1 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5611) Acyl-CoA_dh_N PF02771.16 ETO06267.1 - 0.034 14.8 0.1 0.5 11.0 0.0 2.3 2 0 0 2 2 2 0 Acyl-CoA dehydrogenase, N-terminal domain Atypical_Card PF18461.1 ETO06267.1 - 1.3 9.3 5.3 0.63 10.3 0.3 2.8 3 1 1 4 4 4 0 Atypical caspase recruitment domain F-box-like PF12937.7 ETO06268.1 - 0.00077 19.3 0.1 0.0015 18.4 0.1 1.5 1 0 0 1 1 1 1 F-box-like Pentapeptide PF00805.22 ETO06268.1 - 0.058 13.1 0.1 0.12 12.1 0.1 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (8 copies) F-box PF00646.33 ETO06268.1 - 0.14 12.1 1.0 0.28 11.1 0.1 1.9 2 0 0 2 2 2 0 F-box domain SelP_N PF04592.14 ETO06268.1 - 0.9 8.9 8.1 1.6 8.1 8.1 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region G-patch PF01585.23 ETO06269.1 - 2.4e-08 33.7 6.4 4.7e-08 32.8 6.4 1.4 1 0 0 1 1 1 1 G-patch domain RRM_1 PF00076.22 ETO06269.1 - 0.004 17.0 0.1 0.0099 15.7 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) G-patch_2 PF12656.7 ETO06269.1 - 0.035 14.2 0.1 0.092 12.8 0.1 1.7 1 0 0 1 1 1 0 G-patch domain DUF5484 PF17583.2 ETO06269.1 - 0.089 12.5 1.7 0.27 10.9 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5484) SBP_bac_5 PF00496.22 ETO06269.1 - 0.098 11.6 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding proteins, family 5 Middle Atrophin-1 PF03154.15 ETO06269.1 - 0.96 7.7 8.7 1.2 7.3 8.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 ETO06269.1 - 1.6 8.7 8.4 1.3 9.0 6.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) C1_1 PF00130.22 ETO06270.1 - 0.17 11.8 10.7 0.21 11.5 6.8 3.0 3 0 0 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) SH2 PF00017.24 ETO06271.1 - 2.9e-08 33.7 0.0 7.6e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 SH2 domain Bromodomain PF00439.25 ETO06273.1 - 7.2e-11 42.0 0.5 2.3e-10 40.4 0.1 2.0 2 0 0 2 2 2 1 Bromodomain HetR_C PF18460.1 ETO06274.1 - 0.0019 18.1 1.0 0.011 15.7 0.1 2.2 2 0 0 2 2 2 1 Heterocyst differentiation regulator C-terminal Hood domain PP_M1 PF03012.14 ETO06274.1 - 0.0036 16.9 5.9 0.0056 16.3 5.9 1.3 1 0 0 1 1 1 1 Phosphoprotein Striatin PF08232.12 ETO06274.1 - 0.61 10.7 17.6 2.3 8.8 17.6 1.9 1 1 0 1 1 1 0 Striatin family CDC45 PF02724.14 ETO06274.1 - 1.4 7.2 19.7 1.7 6.9 19.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO06274.1 - 5.5 6.7 17.1 8.4 6.1 17.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 ETO06274.1 - 6.4 5.5 8.8 8.5 5.1 8.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF913 PF06025.12 ETO06274.1 - 7.8 5.4 9.0 10 5.0 9.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) WD40 PF00400.32 ETO06275.1 - 3.4e-38 128.9 11.2 7.4e-11 42.4 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06275.1 - 6.1e-17 61.7 0.1 0.0012 19.1 0.0 4.3 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06275.1 - 3.1e-09 36.2 0.3 0.021 13.8 0.0 3.7 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO06275.1 - 5e-07 29.8 0.2 0.0016 18.4 0.1 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO06275.1 - 5.8e-06 25.8 0.8 0.099 11.9 0.0 2.9 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO06275.1 - 7.3e-06 24.9 2.3 0.12 11.0 0.1 4.4 1 1 4 5 5 5 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO06275.1 - 3e-05 23.5 0.4 0.76 9.0 0.1 3.1 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO06275.1 - 9.1e-05 22.3 4.3 3.5 7.7 0.1 3.5 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO06275.1 - 0.0065 15.4 2.5 0.99 8.3 0.2 3.3 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Utp8 PF10395.9 ETO06275.1 - 0.014 13.9 0.0 0.092 11.2 0.0 1.9 1 1 0 1 1 1 0 Utp8 family DUF5474 PF17568.2 ETO06275.1 - 0.02 15.0 1.1 5.2 7.2 0.0 3.6 2 2 2 4 4 4 0 Family of unknown function (DUF5474) NHL PF01436.21 ETO06275.1 - 0.046 13.8 0.2 4.5 7.5 0.0 3.3 3 0 0 3 3 3 0 NHL repeat Phage_CI_repr PF07022.13 ETO06275.1 - 0.074 13.2 0.0 0.41 10.8 0.0 2.1 2 1 1 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain Cytochrom_D1 PF02239.16 ETO06275.1 - 0.086 11.3 0.0 0.19 10.2 0.0 1.7 1 1 0 1 1 1 0 Cytochrome D1 heme domain Methyltransf_3 PF01596.17 ETO06275.1 - 0.1 11.7 0.0 0.91 8.6 0.0 2.2 2 1 1 3 3 3 0 O-methyltransferase Proteasome_A_N PF10584.9 ETO06275.1 - 0.61 9.8 5.8 50 3.7 0.1 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature BSP_II PF05432.11 ETO06276.1 - 0.33 10.6 19.9 0.033 13.9 15.0 1.8 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) WD40 PF00400.32 ETO06277.1 - 2e-40 136.0 3.9 1.3e-11 44.8 0.1 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06277.1 - 7.2e-13 48.7 0.0 0.00019 21.7 0.0 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06277.1 - 9.3e-12 44.5 2.1 0.0094 14.9 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO06277.1 - 0.00011 22.1 1.6 1.7 8.7 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO06277.1 - 0.00062 19.2 0.1 0.013 14.8 0.0 2.0 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO06277.1 - 0.0048 15.6 0.5 0.27 9.8 0.1 2.6 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO06277.1 - 0.019 14.3 0.1 0.63 9.3 0.0 2.6 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO06277.1 - 0.028 13.0 0.0 0.82 8.1 0.0 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain DUF4875 PF16175.5 ETO06277.1 - 0.062 13.4 0.3 31 4.7 0.0 3.6 1 1 2 4 4 4 0 Domain of unknown function (DUF4875) AcetylCoA_hyd_C PF13336.6 ETO06277.1 - 0.065 13.2 0.0 9.3 6.2 0.0 2.6 2 1 1 3 3 3 0 Acetyl-CoA hydrolase/transferase C-terminal domain Proteasome_A_N PF10584.9 ETO06277.1 - 0.75 9.5 9.8 19 5.0 0.0 5.0 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO06278.1 - 9.3e-21 73.8 5.5 1.3e-05 25.8 0.0 5.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06278.1 - 1.2e-07 32.0 0.0 0.0054 17.0 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06278.1 - 0.029 13.0 2.0 2.4 6.7 0.4 2.9 2 1 0 3 3 3 0 Nucleoporin Nup120/160 DUF285 PF03382.14 ETO06278.1 - 0.043 13.6 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 PD40 PF07676.12 ETO06278.1 - 0.13 12.3 0.2 4.6 7.3 0.0 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat RHS_repeat PF05593.14 ETO06278.1 - 0.23 12.0 0.4 31 5.2 0.1 2.3 2 0 0 2 2 2 0 RHS Repeat Aldo_ket_red PF00248.21 ETO06279.1 - 8e-23 81.1 0.4 1.3e-22 80.4 0.4 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family PI3_PI4_kinase PF00454.27 ETO06281.1 - 8.1e-41 140.5 0.9 1.5e-39 136.3 0.9 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETO06281.1 - 2.2e-28 98.9 3.1 4.4e-28 97.9 3.1 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) AAA_16 PF13191.6 ETO06282.1 - 4.7e-06 27.1 0.0 6.2e-06 26.7 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain dNK PF01712.19 ETO06282.1 - 0.0064 16.4 0.0 0.024 14.5 0.0 1.9 2 0 0 2 2 2 1 Deoxynucleoside kinase DAP3 PF10236.9 ETO06282.1 - 0.014 14.6 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ATPase_2 PF01637.18 ETO06282.1 - 0.029 14.3 0.0 0.046 13.6 0.0 1.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea NB-ARC PF00931.22 ETO06282.1 - 0.034 13.3 0.0 0.044 13.0 0.0 1.2 1 0 0 1 1 1 0 NB-ARC domain AAA_22 PF13401.6 ETO06282.1 - 0.13 12.6 0.0 0.27 11.5 0.0 1.6 2 0 0 2 2 2 0 AAA domain PH PF00169.29 ETO06283.1 - 6.5e-05 23.4 2.9 0.00018 22.0 2.9 1.8 1 0 0 1 1 1 1 PH domain AAA_22 PF13401.6 ETO06283.1 - 0.0035 17.6 0.2 0.014 15.7 0.2 2.1 1 0 0 1 1 1 1 AAA domain PH_8 PF15409.6 ETO06283.1 - 0.011 16.0 0.3 0.032 14.5 0.3 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain AAA_16 PF13191.6 ETO06283.1 - 0.2 12.0 2.0 0.44 10.9 0.2 2.2 2 1 0 2 2 2 0 AAA ATPase domain Tudor-knot PF11717.8 ETO06284.1 - 6.8e-14 51.5 3.8 1.7e-13 50.2 3.8 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF1325 PF07039.11 ETO06284.1 - 7.2e-05 22.9 0.8 0.0018 18.4 0.0 2.9 3 0 0 3 3 3 1 SGF29 tudor-like domain Chromo PF00385.24 ETO06284.1 - 0.0025 17.7 2.6 0.0025 17.7 2.6 1.9 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain Agenet PF05641.12 ETO06284.1 - 0.076 13.5 1.6 0.19 12.2 0.8 2.1 2 0 0 2 2 2 0 Agenet domain DUF4820 PF16091.5 ETO06284.1 - 0.37 10.1 9.6 0.62 9.4 9.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) RuvA_C PF07499.13 ETO06285.1 - 0.053 14.0 0.1 0.1 13.0 0.1 1.4 1 0 0 1 1 1 0 RuvA, C-terminal domain Guanylate_cyc PF00211.20 ETO06286.1 - 6.8e-18 64.9 0.0 2.2e-10 40.4 0.0 2.6 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain SET PF00856.28 ETO06287.1 - 3.1e-12 47.2 0.2 7.2e-12 46.0 0.2 1.7 1 1 0 1 1 1 1 SET domain Bromodomain PF00439.25 ETO06288.1 - 4.6e-14 52.2 1.3 8.9e-14 51.3 1.3 1.4 1 0 0 1 1 1 1 Bromodomain UPF0121 PF03661.13 ETO06288.1 - 0.0099 15.3 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Apolipo_F PF15148.6 ETO06288.1 - 0.041 13.4 1.2 0.068 12.7 1.2 1.4 1 0 0 1 1 1 0 Apolipoprotein F Pex24p PF06398.11 ETO06288.1 - 0.043 12.8 0.0 0.043 12.8 0.0 2.2 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin 7TM_GPCR_Srw PF10324.9 ETO06288.1 - 0.36 10.1 0.0 0.36 10.1 0.0 2.3 2 1 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srw Insulin PF00049.18 ETO06288.1 - 0.66 11.0 3.9 35 5.5 0.0 2.6 2 0 0 2 2 2 0 Insulin/IGF/Relaxin family p450 PF00067.22 ETO06289.1 - 8e-75 252.3 2.1 1e-74 252.0 2.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 HIT PF01230.23 ETO06290.1 - 5.8e-08 33.4 0.0 1.2e-07 32.4 0.0 1.6 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ETO06290.1 - 0.0046 17.4 0.0 0.0069 16.9 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Cir_N PF10197.9 ETO06291.1 - 0.002 18.3 0.4 0.002 18.3 0.4 2.9 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR RNA_binding PF01877.17 ETO06291.1 - 0.25 11.6 3.1 0.61 10.4 1.2 2.0 2 0 0 2 2 2 0 RNA binding NESP55 PF06390.12 ETO06292.1 - 0.00093 18.9 0.8 0.00093 18.9 0.8 1.6 2 0 0 2 2 2 1 Neuroendocrine-specific golgi protein P55 (NESP55) SAM_2 PF07647.17 ETO06292.1 - 0.0068 16.5 0.0 0.15 12.2 0.0 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO06294.1 - 1e-18 67.3 8.8 2.1e-08 34.7 0.4 3.5 4 0 0 4 4 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO06294.1 - 8.9e-07 27.9 0.2 1.5e-05 23.8 0.2 2.0 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06294.1 - 0.00047 20.4 0.2 0.14 12.5 0.0 2.9 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Laminin_II PF06009.12 ETO06294.1 - 0.017 15.1 8.4 0.024 14.7 8.4 1.2 1 0 0 1 1 1 0 Laminin Domain II DUF2924 PF11149.8 ETO06294.1 - 0.019 15.3 0.9 0.039 14.3 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2924) Prominin PF05478.11 ETO06294.1 - 0.057 11.4 7.2 0.068 11.1 7.2 1.0 1 0 0 1 1 1 0 Prominin Phage_HK97_TLTM PF06120.11 ETO06294.1 - 0.12 11.6 6.1 0.17 11.0 6.1 1.2 1 0 0 1 1 1 0 Tail length tape measure protein V-ATPase_G PF03179.15 ETO06294.1 - 0.15 12.6 10.9 0.28 11.7 10.9 1.4 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit DUF2408 PF10303.9 ETO06294.1 - 0.17 12.4 9.6 0.25 11.9 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) LAM_C PF12544.8 ETO06294.1 - 0.27 11.4 1.5 0.39 10.9 0.0 1.9 2 0 0 2 2 2 0 Lysine-2,3-aminomutase WYL_2 PF10902.8 ETO06294.1 - 0.39 11.1 2.7 12 6.3 0.1 2.8 2 1 1 3 3 3 0 WYL_2, Sm-like SH3 beta-barrel fold TMPIT PF07851.13 ETO06294.1 - 3.9 6.6 10.6 5.1 6.2 10.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein zf-TRAF PF02176.18 ETO06295.1 - 0.00019 22.1 1.5 0.00019 22.1 1.5 3.4 3 0 0 3 3 3 2 TRAF-type zinc finger Pkinase PF00069.25 ETO06296.1 - 4.2e-53 180.4 0.0 7.7e-53 179.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06296.1 - 2e-18 66.6 0.0 5.7e-18 65.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 ETO06296.1 - 5.3e-14 52.1 0.0 7.4e-10 38.8 0.0 2.9 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain APH PF01636.23 ETO06296.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family NPR3 PF03666.13 ETO06296.1 - 0.8 8.4 10.0 1.6 7.4 10.0 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MRP-L47 PF06984.13 ETO06297.1 - 0.075 13.2 0.2 0.23 11.6 0.2 1.8 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Myotub-related PF06602.14 ETO06298.1 - 7.9e-31 107.3 0.0 1.2e-30 106.7 0.0 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain OTCace_N PF02729.21 ETO06299.1 - 1.7e-50 170.9 0.0 3.2e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 ETO06299.1 - 1.9e-27 96.3 0.2 4.9e-27 94.9 0.2 1.7 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain WASH_WAHD PF11945.8 ETO06300.1 - 0.11 12.0 0.0 0.26 10.8 0.0 1.6 2 0 0 2 2 2 0 WAHD domain of WASH complex PDR_CDR PF06422.12 ETO06300.1 - 0.31 11.0 0.1 0.31 11.0 0.1 2.2 2 0 0 2 2 2 0 CDR ABC transporter Z1 PF10593.9 ETO06302.1 - 0.043 13.3 6.2 0.054 13.0 6.2 1.0 1 0 0 1 1 1 0 Z1 domain Ndc1_Nup PF09531.10 ETO06302.1 - 0.048 12.4 5.0 0.052 12.2 5.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF2937 PF11157.8 ETO06302.1 - 0.096 12.4 0.2 0.15 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) PepSY_TM_like_2 PF16357.5 ETO06302.1 - 0.29 11.1 2.5 0.39 10.7 2.5 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like SIT PF15330.6 ETO06302.1 - 6.2 7.3 9.2 1.9 9.0 5.7 1.7 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT PDEase_I PF00233.19 ETO06304.1 - 0.049 13.4 0.1 0.073 12.8 0.1 1.3 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Uso1_p115_head PF04869.14 ETO06305.1 - 4.8e-20 71.9 2.7 4.8e-20 71.9 2.7 2.5 2 1 0 2 2 2 1 Uso1 / p115 like vesicle tethering protein, head region Bcr-Abl_Oligo PF09036.10 ETO06305.1 - 0.11 12.6 5.9 0.45 10.6 0.0 3.5 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain DUF3560 PF12083.8 ETO06305.1 - 0.25 11.5 4.2 0.074 13.2 0.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3560) DUF4349 PF14257.6 ETO06305.1 - 1.2 8.6 7.5 7.2 6.0 4.2 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4349) EMP24_GP25L PF01105.24 ETO06305.1 - 2.2 8.2 9.7 5.2 7.0 3.3 3.0 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF1198 PF06711.11 ETO06306.1 - 0.037 14.1 0.3 0.081 13.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1198) Secretin_N_2 PF07655.13 ETO06306.1 - 0.084 13.4 11.1 0.19 12.3 11.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain SMC_hinge PF06470.13 ETO06306.1 - 0.1 12.9 0.5 0.26 11.6 0.5 1.6 1 0 0 1 1 1 0 SMC proteins Flexible Hinge Domain Apis_Csd PF11671.8 ETO06306.1 - 2.2 8.3 14.2 3.9 7.5 14.2 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein HD_3 PF13023.6 ETO06308.1 - 0.0014 18.6 1.8 0.0026 17.7 0.8 1.8 2 0 0 2 2 2 1 HD domain UPF0560 PF10577.9 ETO06308.1 - 0.015 13.8 0.3 0.017 13.7 0.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 MIEAP PF16026.5 ETO06309.1 - 4.2e-08 33.6 1.9 1e-07 32.4 0.1 2.5 2 1 0 3 3 3 1 Mitochondria-eating protein GIT_CC PF16559.5 ETO06310.1 - 0.0015 18.4 2.2 0.0015 18.4 2.2 4.9 3 1 3 6 6 6 1 GIT coiled-coil Rho guanine nucleotide exchange factor Filament PF00038.21 ETO06310.1 - 0.0057 16.3 10.5 0.0057 16.3 10.5 3.2 1 1 2 3 3 3 1 Intermediate filament protein NPV_P10 PF05531.12 ETO06310.1 - 0.035 14.6 32.0 0.41 11.1 3.4 5.0 4 1 0 4 4 4 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 ETO06310.1 - 0.04 14.1 63.9 0.027 14.7 21.3 4.0 2 1 2 4 4 4 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 ETO06310.1 - 0.18 11.9 60.8 0.21 11.7 9.1 4.5 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein ADIP PF11559.8 ETO06310.1 - 0.24 11.5 66.7 0.14 12.2 15.4 4.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 ETO06310.1 - 0.39 11.2 71.7 10 6.6 18.7 4.6 1 1 4 5 5 5 0 Apg6 coiled-coil region CALCOCO1 PF07888.11 ETO06310.1 - 0.54 9.1 61.5 0.02 13.8 27.5 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like LPP PF04728.13 ETO06310.1 - 0.83 10.1 28.9 0.43 11.0 0.3 6.1 6 0 0 6 6 6 0 Lipoprotein leucine-zipper DUF1664 PF07889.12 ETO06310.1 - 1.5 8.8 41.9 0.11 12.6 6.5 4.7 1 1 5 6 6 6 0 Protein of unknown function (DUF1664) FUSC PF04632.12 ETO06310.1 - 2.2 6.7 6.3 1.8 7.0 2.1 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family Fez1 PF06818.15 ETO06310.1 - 2.3 8.7 58.0 0.11 12.9 25.5 3.2 1 1 2 3 3 3 0 Fez1 DASH_Dam1 PF08653.10 ETO06310.1 - 2.3 8.1 9.1 14 5.5 0.2 4.7 3 1 0 3 3 3 0 DASH complex subunit Dam1 Laminin_II PF06009.12 ETO06310.1 - 7.3 6.6 42.9 0.051 13.6 6.2 4.7 1 1 3 4 4 4 0 Laminin Domain II PI3K_P85_iSH2 PF16454.5 ETO06310.1 - 7.7 6.1 55.0 9 5.9 19.6 4.0 1 1 2 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Lebercilin PF15619.6 ETO06310.1 - 7.8 6.1 69.1 0.1 12.2 26.1 3.3 1 1 1 2 2 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF724 PF05266.14 ETO06310.1 - 8.5 6.2 54.3 0.11 12.3 13.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Bacillus_HBL PF05791.11 ETO06310.1 - 9.3 6.0 40.7 0.13 12.1 0.5 4.3 2 2 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) WD40 PF00400.32 ETO06311.1 - 9.2e-28 95.9 26.8 4.7e-05 24.1 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06311.1 - 1.5e-09 38.1 0.7 0.48 10.8 0.0 4.6 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain VID27 PF08553.10 ETO06311.1 - 0.00098 18.3 0.0 0.0054 15.8 0.0 2.1 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain Nup160 PF11715.8 ETO06311.1 - 0.0068 15.1 1.4 0.35 9.5 0.0 2.4 3 0 0 3 3 3 2 Nucleoporin Nup120/160 PPDK_N PF01326.19 ETO06311.1 - 0.028 13.7 0.7 0.041 13.1 0.7 1.2 1 0 0 1 1 1 0 Pyruvate phosphate dikinase, PEP/pyruvate binding domain Med9 PF07544.13 ETO06311.1 - 0.05 13.7 1.2 0.05 13.7 1.2 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 WD40_like PF17005.5 ETO06311.1 - 0.062 12.6 2.2 2 7.7 0.1 3.0 2 1 0 3 3 3 0 WD40-like domain HNF_C PF09354.10 ETO06311.1 - 0.12 13.4 0.0 0.29 12.2 0.0 1.6 1 0 0 1 1 1 0 HNF3 C-terminal domain WD40 PF00400.32 ETO06312.1 - 7.1e-61 200.7 27.8 1.5e-09 38.3 0.6 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06312.1 - 2.1e-23 82.4 4.1 0.001 19.3 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06312.1 - 4.8e-15 55.3 3.2 0.21 10.5 0.0 6.3 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO06312.1 - 4.7e-12 46.2 0.2 2.8e-07 30.6 0.0 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO06312.1 - 8.7e-08 31.2 5.4 0.74 8.4 0.0 5.6 2 1 4 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06312.1 - 2.7e-07 30.2 0.2 0.17 11.1 0.0 3.3 3 0 0 3 3 3 3 WD40-like domain Nbas_N PF15492.6 ETO06312.1 - 9.1e-07 28.5 4.0 0.57 9.5 0.1 4.5 1 1 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO06312.1 - 2.7e-05 23.4 0.5 0.035 13.2 0.1 2.5 1 1 0 2 2 2 2 Coatomer WD associated region PQQ PF01011.21 ETO06312.1 - 0.00026 20.7 0.1 4.4 7.4 0.0 5.4 7 0 0 7 7 7 1 PQQ enzyme repeat PQQ_2 PF13360.6 ETO06312.1 - 0.0039 16.8 0.4 0.024 14.2 0.4 2.4 1 1 0 1 1 1 1 PQQ-like domain Rav1p_C PF12234.8 ETO06312.1 - 0.0057 15.1 0.2 0.12 10.8 0.0 2.1 2 0 0 2 2 2 1 RAVE protein 1 C terminal DUF5570 PF17731.1 ETO06312.1 - 0.0063 16.6 1.5 30 4.7 0.1 4.8 3 1 3 6 6 6 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO06312.1 - 0.016 15.1 7.1 44 4.2 0.0 6.5 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO06312.1 - 0.035 13.8 10.0 5.6 6.8 0.0 4.9 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 ETO06312.1 - 0.11 11.4 2.4 9.7 5.0 0.1 3.2 3 2 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain GDI PF00996.18 ETO06313.1 - 0.081 11.4 0.4 0.24 9.9 0.4 1.6 1 1 0 1 1 1 0 GDP dissociation inhibitor Kelch_6 PF13964.6 ETO06315.1 - 1.8e-09 37.5 5.8 2.5e-06 27.6 0.2 4.4 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO06315.1 - 5.2e-05 22.8 10.6 0.00026 20.5 0.2 5.4 6 1 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 ETO06315.1 - 0.00016 21.6 1.0 0.002 18.1 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO06315.1 - 0.00032 20.9 0.0 0.0036 17.6 0.0 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06315.1 - 2.9 8.0 7.6 1 9.4 0.3 3.6 4 0 0 4 4 4 0 Kelch motif RRM_1 PF00076.22 ETO06316.1 - 4.9e-15 55.1 1.8 6.4e-09 35.5 0.0 4.4 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NOA36 PF06524.12 ETO06316.1 - 0.63 9.3 4.5 1.1 8.5 4.5 1.3 1 0 0 1 1 1 0 NOA36 protein ATG16 PF08614.11 ETO06318.1 - 1e-10 42.2 10.9 1.2e-10 42.0 10.9 1.0 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 ETO06318.1 - 0.038 13.3 4.7 0.046 13.1 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ETO06318.1 - 0.88 9.1 5.7 1.2 8.7 5.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PRKG1_interact PF15898.5 ETO06318.1 - 1.6 9.7 14.7 1.5 9.7 9.1 2.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF745 PF05335.13 ETO06318.1 - 4.3 7.0 10.8 5.1 6.8 10.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF745) CN_hydrolase PF00795.22 ETO06319.1 - 5.4e-20 71.8 0.0 2.5e-19 69.6 0.0 1.8 1 1 0 1 1 1 1 Carbon-nitrogen hydrolase Zip PF02535.22 ETO06320.1 - 1.4e-14 54.1 10.6 2e-14 53.5 3.4 3.3 1 1 1 3 3 3 1 ZIP Zinc transporter CPP1-like PF11833.8 ETO06320.1 - 0.21 11.2 0.8 2.1 8.0 0.5 2.3 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like WD40 PF00400.32 ETO06321.1 - 0.0017 19.2 4.2 0.012 16.4 0.7 3.6 4 0 0 4 4 4 1 WD domain, G-beta repeat WD40 PF00400.32 ETO06322.1 - 3e-18 65.8 6.0 4.1e-06 27.4 0.2 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO06322.1 - 2.1e-07 30.5 2.6 1.4e-06 27.8 2.0 2.2 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) ANAPC4_WD40 PF12894.7 ETO06322.1 - 2.1e-05 24.7 0.6 0.0058 16.9 0.0 2.8 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide_3 PF13576.6 ETO06322.1 - 2.2e-05 24.5 1.8 3.8e-05 23.8 1.8 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 ETO06322.1 - 0.0039 17.3 4.3 0.017 15.3 4.2 2.1 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) HAT_KAT11 PF08214.11 ETO06324.1 - 0.16 11.2 4.7 0.18 11.0 4.7 1.1 1 0 0 1 1 1 0 Histone acetylation protein DMP12 PF16779.5 ETO06326.1 - 0.002 18.1 0.1 0.0048 16.9 0.1 1.6 1 0 0 1 1 1 1 DNA-mimic protein CelTOS PF18659.1 ETO06326.1 - 0.18 12.3 3.1 1.8 9.0 0.3 2.7 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites VPS13_C PF16909.5 ETO06327.1 - 0.0014 18.5 0.4 0.0025 17.6 0.1 1.6 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal DUF4834 PF16118.5 ETO06328.1 - 3 8.9 11.3 3.5 8.7 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO06328.1 - 7 5.3 6.0 7.1 5.3 6.0 1.0 1 0 0 1 1 1 0 Presenilin TYW3 PF02676.14 ETO06329.1 - 0.14 11.5 0.0 0.17 11.3 0.0 1.0 1 0 0 1 1 1 0 Methyltransferase TYW3 CENP-B_dimeris PF09026.10 ETO06329.1 - 1.2 9.6 21.5 1.4 9.3 21.5 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO06329.1 - 1.6 8.4 8.1 1.6 8.4 8.1 1.1 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 ETO06329.1 - 2.2 8.0 9.5 2.1 8.1 9.5 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2722 PF10846.8 ETO06329.1 - 4.5 6.1 9.1 4.4 6.1 9.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RXT2_N PF08595.11 ETO06329.1 - 5.7 7.0 10.7 5.7 6.9 10.7 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4637 PF15470.6 ETO06329.1 - 6.7 6.4 9.8 6.7 6.4 9.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3328 PF11807.8 ETO06330.1 - 0.032 14.0 1.8 5.3 6.8 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) WD40 PF00400.32 ETO06331.1 - 1.6e-36 123.7 11.2 2.3e-09 37.7 0.1 7.0 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06331.1 - 1.1e-11 44.9 0.8 0.1 12.9 0.1 5.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06331.1 - 6.9e-08 32.2 5.8 0.021 14.1 0.0 3.1 2 1 1 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO06331.1 - 5e-06 26.5 3.0 0.0021 18.0 0.3 3.3 1 1 3 4 4 4 1 Eukaryotic translation initiation factor eIF2A B_lectin PF01453.24 ETO06331.1 - 4.6e-05 23.9 1.1 0.029 14.9 0.1 2.8 2 1 1 3 3 3 2 D-mannose binding lectin PD40 PF07676.12 ETO06331.1 - 0.0038 17.1 0.2 7.6 6.6 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat SBD PF17882.1 ETO06331.1 - 0.087 12.7 1.2 1.5 8.7 0.0 2.8 3 0 0 3 3 3 0 OAA-family lectin sugar binding domain TPR_12 PF13424.6 ETO06332.1 - 1.9e-60 201.1 6.8 4.4e-19 68.6 0.2 5.0 3 1 2 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06332.1 - 2.5e-48 160.7 0.0 1.3e-09 37.6 0.0 6.8 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06332.1 - 1.8e-45 150.9 23.9 2.9e-09 36.3 0.3 7.6 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06332.1 - 4.3e-43 142.2 2.2 1.5e-06 27.8 0.0 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06332.1 - 1.6e-34 115.2 23.9 1.2e-06 28.3 0.4 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06332.1 - 5.5e-30 101.1 15.8 2.4e-06 27.2 0.3 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO06332.1 - 1.1e-14 53.6 4.0 0.03 14.7 0.0 7.8 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO06332.1 - 8.7e-13 47.9 0.0 0.99 10.4 0.0 7.2 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06332.1 - 3.2e-10 40.0 4.3 0.79 10.5 0.0 6.8 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06332.1 - 1.6e-08 34.1 25.8 0.025 14.3 3.3 9.4 7 3 3 10 10 10 2 TPR repeat TPR_16 PF13432.6 ETO06332.1 - 8.3e-08 32.8 0.0 4.1 8.1 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat MIT PF04212.18 ETO06332.1 - 1.2e-07 31.7 14.5 0.71 10.0 0.1 7.2 7 1 1 8 8 8 3 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO06332.1 - 2.3e-07 30.7 4.6 0.00092 19.2 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat PPR PF01535.20 ETO06332.1 - 1.1e-05 25.3 9.0 2.2 8.7 0.0 6.8 8 0 0 8 8 7 1 PPR repeat DUF5113 PF17140.4 ETO06332.1 - 5.6e-05 23.0 5.8 0.37 10.6 1.1 4.8 3 2 1 4 4 4 2 Domain of unknown function (DUF5113) DUF2225 PF09986.9 ETO06332.1 - 0.0001 22.1 9.1 0.12 12.0 0.1 3.8 1 1 2 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) SHNi-TPR PF10516.9 ETO06332.1 - 0.00011 21.6 2.3 5 6.7 0.0 5.4 6 0 0 6 6 6 1 SHNi-TPR TPR_19 PF14559.6 ETO06332.1 - 0.00066 20.1 0.2 33 5.1 0.0 5.0 5 1 1 6 6 5 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO06332.1 - 0.0014 18.2 4.9 0.72 9.3 0.2 4.4 3 1 1 4 4 4 1 Meiosis protein SPO22/ZIP4 like Sel1 PF08238.12 ETO06332.1 - 0.0051 17.4 0.6 61 4.5 0.0 4.4 3 0 0 3 3 3 0 Sel1 repeat TPR_MalT PF17874.1 ETO06332.1 - 0.0069 15.8 0.0 0.25 10.7 0.0 2.8 2 1 1 3 3 3 1 MalT-like TPR region NRBF2_MIT PF17169.4 ETO06332.1 - 0.0098 16.1 2.4 0.37 11.0 0.1 3.4 2 1 0 3 3 3 1 MIT domain of nuclear receptor-binding factor 2 ATR13 PF16829.5 ETO06332.1 - 0.029 14.7 1.7 0.35 11.2 0.2 3.0 2 1 0 2 2 2 0 Avirulence protein ATR13, RxLR effector EF-hand_1 PF00036.32 ETO06333.1 - 4.8e-19 66.4 0.6 2.9e-06 26.4 0.0 3.3 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ETO06333.1 - 5e-16 57.2 1.8 6.6e-06 25.6 0.1 3.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 ETO06333.1 - 4.3e-13 49.5 0.4 4.4e-07 30.2 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO06333.1 - 1.3e-11 43.4 6.2 0.0049 16.3 0.2 3.6 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO06333.1 - 1.2e-09 37.8 2.0 0.0003 20.6 0.0 3.4 1 1 2 3 3 3 3 EF-hand domain pair RuvA_C PF07499.13 ETO06333.1 - 1e-07 32.3 0.4 0.0058 17.0 0.0 2.8 3 0 0 3 3 3 2 RuvA, C-terminal domain EF-hand_4 PF12763.7 ETO06333.1 - 2.7e-05 24.1 0.6 0.0065 16.4 0.1 2.9 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand UBA PF00627.31 ETO06333.1 - 0.00083 19.2 0.0 0.54 10.2 0.0 2.4 2 0 0 2 2 2 2 UBA/TS-N domain UB2H PF14814.6 ETO06333.1 - 0.0034 17.4 0.1 0.11 12.5 0.0 2.7 2 2 1 3 3 3 1 Bifunctional transglycosylase second domain Antig_Caf1 PF09255.10 ETO06333.1 - 0.014 15.5 0.0 0.081 13.0 0.0 1.8 1 1 1 2 2 2 0 Caf1 Capsule antigen SPARC_Ca_bdg PF10591.9 ETO06333.1 - 0.015 15.6 0.0 0.49 10.7 0.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Lip_prot_lig_C PF10437.9 ETO06333.1 - 0.067 13.2 0.3 7.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial lipoate protein ligase C-terminus DUF2407_C PF13373.6 ETO06333.1 - 0.084 13.0 0.2 1.4 9.1 0.0 2.3 2 1 0 2 2 2 0 DUF2407 C-terminal domain ABC_tran PF00005.27 ETO06334.1 - 1.1e-10 42.2 0.0 1.4e-10 41.8 0.0 1.2 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO06334.1 - 0.0075 15.7 0.0 0.0087 15.5 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain CBM53 PF16760.5 ETO06335.1 - 0.18 12.4 3.3 2.3 8.8 1.4 2.6 2 0 0 2 2 2 0 Starch/carbohydrate-binding module (family 53) Myc_target_1 PF15179.6 ETO06335.1 - 0.52 10.2 4.3 0.11 12.4 0.4 1.9 3 0 0 3 3 3 0 Myc target protein 1 SCF PF02404.15 ETO06337.1 - 0.026 13.9 0.5 0.027 13.8 0.5 1.1 1 0 0 1 1 1 0 Stem cell factor DUF2951 PF11166.8 ETO06337.1 - 0.19 12.0 7.4 0.18 12.0 6.6 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) LRRC37AB_C PF14914.6 ETO06338.1 - 0.038 13.9 2.1 0.058 13.3 2.1 1.4 1 1 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain B56 PF01603.20 ETO06338.1 - 0.22 10.4 8.7 2.3 7.1 0.1 2.0 1 1 1 2 2 2 0 Protein phosphatase 2A regulatory B subunit (B56 family) DUF3128 PF11326.8 ETO06338.1 - 4 7.9 7.1 6.5 7.2 7.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3128) WD40 PF00400.32 ETO06339.1 - 0.001 19.8 0.0 0.0026 18.5 0.0 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat zf-RING-like PF08746.11 ETO06339.1 - 0.076 13.3 2.8 0.23 11.8 0.1 2.7 1 1 1 2 2 2 0 RING-like domain WD40 PF00400.32 ETO06340.1 - 1.2e-11 44.9 13.2 2.4e-06 28.2 1.9 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06340.1 - 0.01 16.1 0.1 0.16 12.3 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RVT_1 PF00078.27 ETO06342.1 - 0.0031 17.1 0.1 0.02 14.4 0.0 2.0 1 1 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 ETO06344.1 - 1.4e-15 57.4 9.9 5.5e-05 23.8 2.1 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06344.1 - 1.2e-05 25.5 2.2 0.029 14.6 0.1 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06344.1 - 0.00013 20.7 3.4 0.026 13.2 0.5 2.7 1 1 2 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO06344.1 - 0.0036 17.3 1.4 0.31 11.1 0.1 2.4 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ETO06344.1 - 0.0041 16.5 2.7 0.19 11.0 0.1 2.2 2 0 0 2 2 2 2 WD40-like domain Nucleoporin_N PF08801.11 ETO06344.1 - 0.03 13.1 3.7 0.21 10.3 3.7 2.0 1 1 0 1 1 1 0 Nup133 N terminal like ETRAMP PF09716.10 ETO06346.1 - 0.12 12.5 0.2 0.12 12.5 0.2 3.4 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PDR_CDR PF06422.12 ETO06346.1 - 0.36 10.8 2.8 1.7 8.6 0.0 2.6 3 0 0 3 3 3 0 CDR ABC transporter Sec62 PF03839.16 ETO06346.1 - 4.3 6.8 0.0 4.3 6.8 0.0 3.3 2 1 0 2 2 2 0 Translocation protein Sec62 Baculo_11_kDa PF06143.11 ETO06346.1 - 6.5 6.4 7.0 6.9 6.3 2.7 2.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family WD40 PF00400.32 ETO06347.1 - 2.3e-20 72.5 16.6 7.4e-07 29.8 0.6 5.2 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06347.1 - 1.6e-05 25.1 0.9 0.4 11.0 0.2 3.7 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06347.1 - 0.00014 20.7 5.0 1.1 7.8 0.1 3.4 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Peptidase_M54 PF07998.11 ETO06348.1 - 0.029 14.3 0.8 0.071 13.1 0.2 1.8 2 0 0 2 2 2 0 Peptidase family M54 ASH PF15780.5 ETO06349.1 - 0.058 13.6 0.0 2.7 8.2 0.0 2.5 2 0 0 2 2 2 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Menin PF05053.13 ETO06350.1 - 0.2 10.0 5.8 0.28 9.5 5.8 1.1 1 0 0 1 1 1 0 Menin RBD-FIP PF09457.10 ETO06350.1 - 0.25 11.3 2.3 0.51 10.3 2.3 1.5 1 0 0 1 1 1 0 FIP domain CLN3 PF02487.17 ETO06351.1 - 0.038 13.0 0.0 0.048 12.7 0.0 1.1 1 0 0 1 1 1 0 CLN3 protein MMM1 PF10296.9 ETO06351.1 - 0.041 12.9 0.4 0.058 12.4 0.4 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Folate_carrier PF01770.18 ETO06351.1 - 0.054 12.2 0.4 0.077 11.7 0.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Zip PF02535.22 ETO06351.1 - 0.14 11.4 0.4 0.14 11.3 0.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2663 PF10864.8 ETO06352.1 - 0.035 14.5 0.6 0.058 13.8 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) Kelch_6 PF13964.6 ETO06353.1 - 3.7e-05 23.8 2.4 0.73 10.2 0.0 4.3 4 1 1 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO06353.1 - 0.0018 18.2 0.5 18 5.5 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO06353.1 - 0.0026 17.3 0.6 1.4 8.6 0.1 3.6 3 1 0 3 3 3 2 Kelch motif zf-C3HC4_2 PF13923.6 ETO06354.1 - 0.0038 17.0 2.3 0.34 10.8 0.0 2.4 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO06354.1 - 0.12 12.3 4.3 0.7 9.8 4.3 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RNase_H PF00075.24 ETO06355.1 - 8.5e-07 29.3 0.0 2.1e-05 24.7 0.0 2.1 1 1 1 2 2 2 2 RNase H Menin PF05053.13 ETO06356.1 - 0.82 7.9 5.1 1.1 7.5 5.1 1.1 1 0 0 1 1 1 0 Menin SAM_1 PF00536.30 ETO06357.1 - 2.4e-07 31.1 0.3 5.1e-07 30.0 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO06357.1 - 4.9e-05 23.3 0.5 0.00014 21.9 0.1 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO06357.1 - 7e-05 22.7 1.5 0.00013 21.8 0.4 2.0 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain DUF2070 PF09843.9 ETO06357.1 - 2.7 6.2 11.3 0.052 11.8 4.0 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Synaptobrevin PF00957.21 ETO06357.1 - 4.1 7.3 8.3 0.31 10.8 1.0 2.7 2 0 0 2 2 2 0 Synaptobrevin Rhodanese PF00581.20 ETO06360.1 - 1.7e-29 102.5 0.1 1.6e-13 51.1 0.0 2.1 2 0 0 2 2 2 2 Rhodanese-like domain Trnau1ap PF17654.1 ETO06360.1 - 0.065 14.1 0.5 0.065 14.1 0.5 1.9 2 1 0 2 2 2 0 Selenocysteine tRNA 1 associated proteins TPR_1 PF00515.28 ETO06361.1 - 0.00017 21.3 0.2 0.00017 21.3 0.2 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06361.1 - 0.0022 18.0 0.3 0.0051 16.8 0.3 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06361.1 - 0.0068 16.5 0.1 0.032 14.4 0.1 2.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO06361.1 - 0.031 14.7 0.2 0.18 12.3 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06361.1 - 0.69 10.7 2.5 0.52 11.1 0.5 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF45 PF01863.17 ETO06362.1 - 0.27 11.2 3.4 0.41 10.7 3.3 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF45 IBR PF01485.21 ETO06363.1 - 2e-11 43.9 25.6 8.5e-10 38.7 9.3 4.1 4 0 0 4 4 4 3 IBR domain, a half RING-finger domain zf-RING_UBOX PF13445.6 ETO06363.1 - 2.4e-05 24.3 4.6 2.4e-05 24.3 4.6 4.1 4 0 0 4 4 4 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO06363.1 - 3.3e-05 23.7 5.8 3.3e-05 23.7 5.8 6.1 5 1 1 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO06363.1 - 0.00016 21.4 3.8 0.00016 21.4 3.8 5.6 6 1 1 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO06363.1 - 0.007 16.5 1.5 0.007 16.5 1.5 5.4 5 2 1 6 6 6 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ETO06363.1 - 0.017 15.4 7.6 0.017 15.4 7.6 5.0 3 1 1 4 4 4 0 Ring finger domain DUF2607 PF10795.9 ETO06364.1 - 0.051 13.7 0.6 0.12 12.5 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2607) Chordopox_L2 PF05803.12 ETO06364.1 - 0.72 9.7 5.3 0.077 12.8 0.7 1.7 2 0 0 2 2 2 0 Chordopoxvirus L2 protein Herpes_UL69 PF05459.12 ETO06368.1 - 0.0028 17.1 3.1 0.0075 15.6 3.1 1.7 1 0 0 1 1 1 1 Herpesvirus transcriptional regulator family PRO8NT PF08082.11 ETO06370.1 - 0.38 10.7 2.3 0.68 9.9 2.3 1.3 1 0 0 1 1 1 0 PRO8NT (NUC069), PrP8 N-terminal domain V_ATPase_I PF01496.19 ETO06370.1 - 3.5 5.4 4.5 2.3 6.0 2.3 1.7 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TPR_MLP1_2 PF07926.12 ETO06371.1 - 0.0056 16.8 13.7 0.094 12.8 0.1 2.8 3 0 0 3 3 3 2 TPR/MLP1/MLP2-like protein zf-RING-like PF08746.11 ETO06371.1 - 0.13 12.6 1.8 0.58 10.5 0.1 2.4 1 1 1 2 2 2 0 RING-like domain TMPIT PF07851.13 ETO06371.1 - 0.24 10.6 9.9 0.4 9.9 9.9 1.5 1 0 0 1 1 1 0 TMPIT-like protein AviRa PF11599.8 ETO06371.1 - 0.85 9.0 6.9 2.2 7.7 1.3 2.3 1 1 1 2 2 2 0 RRNA methyltransferase AviRa DUF1664 PF07889.12 ETO06371.1 - 5.4 7.1 11.6 13 5.8 3.4 2.9 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) CENP-C_mid PF15620.6 ETO06372.1 - 0.045 13.7 9.7 0.049 13.6 9.7 1.0 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region Connexin PF00029.19 ETO06372.1 - 0.27 11.0 2.8 0.31 10.8 2.8 1.0 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.10 ETO06372.1 - 1 9.4 8.7 1.2 9.2 8.7 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RRM_1 PF00076.22 ETO06373.1 - 2.3e-15 56.1 0.0 4.5e-15 55.2 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Trypan_PARP PF05887.11 ETO06375.1 - 0.27 11.2 4.3 0.64 10.0 0.3 2.3 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ipi1_N PF12333.8 ETO06376.1 - 0.0025 18.4 5.3 0.008 16.7 0.3 3.3 3 0 0 3 3 3 1 Rix1 complex component involved in 60S ribosome maturation RhoGAP PF00620.27 ETO06376.1 - 0.056 13.3 0.4 0.23 11.2 0.2 2.1 1 1 0 1 1 1 0 RhoGAP domain DUF4207 PF13904.6 ETO06376.1 - 0.2 11.3 3.4 0.39 10.4 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4207) WD40 PF00400.32 ETO06377.1 - 5.8e-28 96.6 17.4 9.7e-05 23.1 0.1 7.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06377.1 - 1.8e-07 31.4 3.6 0.72 10.2 0.1 5.8 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06377.1 - 0.00021 20.1 10.7 2 7.0 0.9 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40 PF00400.32 ETO06378.1 - 2.4e-07 31.3 2.0 6.5e-07 29.9 0.5 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40_like PF17005.5 ETO06378.1 - 0.00033 20.1 0.6 0.00051 19.5 0.6 1.3 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO06378.1 - 0.0023 16.6 0.2 0.0028 16.4 0.2 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 Dzip-like_N PF13815.6 ETO06379.1 - 0.11 12.4 5.2 0.4 10.6 4.9 1.7 1 1 1 2 2 2 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal DUF4795 PF16043.5 ETO06379.1 - 0.23 11.0 6.6 0.28 10.8 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Ank_4 PF13637.6 ETO06380.1 - 3e-09 37.2 0.0 1.4e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO06380.1 - 2.2e-07 31.3 0.2 4.1e-06 27.3 0.2 2.7 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO06380.1 - 2.4e-06 27.4 0.1 0.074 13.6 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO06380.1 - 1e-05 25.7 0.6 0.00066 19.9 0.3 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO06380.1 - 0.00021 21.6 0.1 0.58 10.7 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Blt1 PF12754.7 ETO06381.1 - 0.02 15.2 0.0 0.024 14.9 0.0 1.2 1 0 0 1 1 1 0 Blt1 N-terminal domain HIP1_clath_bdg PF16515.5 ETO06382.1 - 3.1 8.5 18.6 0.17 12.5 12.2 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 FEZ PF07763.13 ETO06383.1 - 0.033 13.9 1.8 0.039 13.7 1.8 1.0 1 0 0 1 1 1 0 FEZ-like protein CRAL_TRIO PF00650.20 ETO06384.1 - 2.3e-11 43.7 4.4 4.2e-09 36.3 4.4 2.1 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ETO06384.1 - 0.00038 20.6 2.0 0.0038 17.4 2.0 2.1 1 1 0 1 1 1 1 Divergent CRAL/TRIO domain FAM176 PF14851.6 ETO06387.1 - 0.11 12.2 0.0 0.2 11.3 0.0 1.4 1 0 0 1 1 1 0 FAM176 family Baculo_11_kDa PF06143.11 ETO06387.1 - 7.1 6.3 8.4 1.9 8.2 0.1 3.2 2 1 1 3 3 3 0 Baculovirus 11 kDa family FAM60A PF15396.6 ETO06388.1 - 0.037 14.0 13.6 0.049 13.6 6.3 2.3 2 0 0 2 2 2 0 Protein Family FAM60A SPX PF03105.19 ETO06388.1 - 0.13 12.2 23.4 0.11 12.4 6.1 2.1 2 0 0 2 2 2 0 SPX domain VKG_Carbox PF05090.14 ETO06388.1 - 0.31 9.8 0.0 0.31 9.8 0.0 1.5 2 0 0 2 2 2 0 Vitamin K-dependent gamma-carboxylase CLN3 PF02487.17 ETO06388.1 - 0.35 9.9 3.9 0.63 9.0 0.8 2.3 2 1 0 2 2 2 0 CLN3 protein Peroxin-13_N PF04088.13 ETO06388.1 - 2.9 8.2 6.6 35 4.6 5.0 2.7 2 1 0 2 2 2 0 Peroxin 13, N-terminal region DUF4379 PF14311.6 ETO06389.1 - 0.049 14.0 1.1 0.19 12.1 1.1 2.0 1 0 0 1 1 1 0 Probable Zinc-ribbon domain AOC_like PF18678.1 ETO06389.1 - 0.086 12.4 0.1 0.16 11.6 0.1 1.3 1 0 0 1 1 1 0 Allene oxide cyclase barrel like domain LZ3wCH PF18517.1 ETO06390.1 - 0.019 15.1 0.1 0.056 13.5 0.1 1.8 1 0 0 1 1 1 0 Leucine zipper with capping helix domain Lyase_8 PF02278.18 ETO06390.1 - 0.068 12.6 0.4 0.09 12.2 0.4 1.1 1 0 0 1 1 1 0 Polysaccharide lyase family 8, super-sandwich domain Kelch_6 PF13964.6 ETO06391.1 - 0.00064 19.9 0.3 0.0033 17.6 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO06391.1 - 0.00067 19.6 0.1 0.088 12.8 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO06391.1 - 0.15 12.1 0.3 3.6 7.7 0.1 2.5 2 0 0 2 2 2 0 Kelch motif ETRAMP PF09716.10 ETO06391.1 - 0.46 10.6 4.9 2.7 8.1 1.7 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) zf-TRAF PF02176.18 ETO06392.1 - 8.2e-12 45.6 6.4 8.2e-12 45.6 6.4 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger PH PF00169.29 ETO06392.1 - 5.8e-06 26.8 1.0 1.3e-05 25.7 0.1 2.0 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO06392.1 - 6.5e-05 23.3 6.6 0.00024 21.5 0.1 3.1 2 1 0 2 2 2 1 Pleckstrin homology domain TelA PF05816.11 ETO06392.1 - 8.4e-05 21.8 4.3 0.00012 21.3 4.3 1.3 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) PH_3 PF14593.6 ETO06392.1 - 0.0038 17.3 3.2 0.0082 16.2 0.1 2.5 3 0 0 3 3 3 1 PH domain DUF1664 PF07889.12 ETO06392.1 - 0.025 14.6 1.0 0.025 14.6 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) PH_8 PF15409.6 ETO06392.1 - 0.17 12.1 0.2 0.17 12.1 0.2 2.2 2 1 1 3 3 3 0 Pleckstrin homology domain zf-FCS PF06467.14 ETO06392.1 - 0.18 11.7 1.8 0.6 10.1 1.8 1.8 1 0 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif DUF4047 PF13256.6 ETO06392.1 - 0.89 9.8 5.6 0.34 11.1 2.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) Serpin PF00079.20 ETO06393.1 - 5.9e-09 35.7 1.3 3.9e-08 33.0 1.3 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF1363 PF07101.11 ETO06393.1 - 0.0042 17.4 0.1 0.0076 16.5 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1363) DNA_primase_S PF01896.19 ETO06394.1 - 8.2e-05 22.7 1.8 0.00013 22.1 0.7 2.0 2 0 0 2 2 2 1 DNA primase small subunit zf-C3HC4_3 PF13920.6 ETO06394.1 - 0.0028 17.5 7.3 0.0028 17.5 7.3 4.4 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO06394.1 - 0.0044 17.0 10.5 0.0044 17.0 10.5 4.4 5 0 0 5 5 5 1 zinc-RING finger domain NARP1 PF12569.8 ETO06395.1 - 0.53 9.1 27.6 0.048 12.6 16.6 2.3 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 DUF4407 PF14362.6 ETO06395.1 - 1.7 7.9 7.5 4.5 6.5 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SID-1_RNA_chan PF13965.6 ETO06395.1 - 3.8 5.8 7.0 0.39 9.1 1.4 2.0 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PA26 PF04636.13 ETO06395.1 - 9.7 5.0 12.6 3.1 6.6 5.6 2.3 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) zf-TRAF PF02176.18 ETO06398.1 - 0.0057 17.3 2.2 0.0057 17.3 2.2 2.5 2 1 1 3 3 3 1 TRAF-type zinc finger Kelch_4 PF13418.6 ETO06399.1 - 7.6e-06 25.8 0.1 0.0011 18.9 0.0 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO06399.1 - 6.3e-05 22.5 0.5 0.00015 21.3 0.3 1.7 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO06399.1 - 0.00015 21.6 0.3 0.35 10.9 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO06399.1 - 0.015 15.5 0.0 0.041 14.2 0.0 1.8 2 0 0 2 2 2 0 Galactose oxidase, central domain SAM_2 PF07647.17 ETO06404.1 - 0.0058 16.7 0.1 0.012 15.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO06404.1 - 0.0062 17.0 0.0 0.014 15.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MIP PF00230.20 ETO06405.1 - 1.1e-18 67.8 1.5 1.8e-18 67.1 1.5 1.3 1 1 0 1 1 1 1 Major intrinsic protein AAA_7 PF12775.7 ETO06406.1 - 0.00095 18.7 0.1 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETO06406.1 - 0.0024 18.4 0.7 0.016 15.7 0.1 2.1 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ETO06406.1 - 0.011 16.0 0.0 0.03 14.6 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ETO06406.1 - 0.019 15.4 0.2 0.053 13.9 0.2 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Sod_Ni PF09055.11 ETO06406.1 - 0.022 15.3 0.4 0.039 14.5 0.4 1.3 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase TsaE PF02367.17 ETO06406.1 - 0.057 13.4 0.1 0.15 12.1 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 ETO06406.1 - 0.08 12.7 0.9 0.21 11.3 0.1 2.0 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 ETO06406.1 - 0.084 12.6 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_16 PF13191.6 ETO06406.1 - 0.11 12.9 0.0 0.4 11.0 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain HAD_2 PF13419.6 ETO06407.1 - 2.2 8.3 0.0 2.2 8.3 0.0 4.4 4 1 0 4 4 4 0 Haloacid dehalogenase-like hydrolase NACHT PF05729.12 ETO06409.1 - 2.1e-09 37.5 0.0 4.1e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain RelA_SpoT PF04607.17 ETO06409.1 - 3e-05 24.3 3.5 0.00018 21.7 0.9 2.6 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins AAA_18 PF13238.6 ETO06409.1 - 0.0016 19.0 0.1 0.0071 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO06409.1 - 0.014 15.9 0.0 0.037 14.5 0.0 1.8 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ETO06409.1 - 0.024 14.9 0.1 0.083 13.2 0.1 2.0 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO06409.1 - 0.086 12.8 0.0 0.63 10.0 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE WD40 PF00400.32 ETO06410.1 - 3e-96 312.7 55.5 5.9e-08 33.3 0.1 15.3 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06410.1 - 2.8e-20 72.4 11.9 0.0027 17.9 0.0 11.5 1 1 12 14 14 14 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06410.1 - 3.5e-15 55.8 7.4 0.19 10.6 0.0 11.0 2 2 8 10 10 10 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO06410.1 - 1.1e-05 25.0 8.3 1.9 7.7 0.0 6.1 2 2 4 7 7 7 4 WD40-like domain Pentapeptide PF00805.22 ETO06410.1 - 0.00046 19.8 1.3 0.00046 19.8 1.3 2.8 4 0 0 4 4 4 1 Pentapeptide repeats (8 copies) DUF3475 PF11961.8 ETO06410.1 - 0.00048 20.2 0.4 49 4.1 0.0 6.1 6 0 0 6 6 6 0 Domain of unknown function (DUF3475) Mid2 PF04478.12 ETO06410.1 - 0.0018 18.1 0.6 0.3 10.9 0.0 4.5 4 2 1 5 5 5 1 Mid2 like cell wall stress sensor HARP PF07443.13 ETO06410.1 - 0.087 12.5 4.5 1.2e+02 2.4 0.0 5.8 7 0 0 7 7 7 0 HepA-related protein (HARP) DUF5478 PF17572.2 ETO06410.1 - 0.16 12.1 0.4 0.82 9.8 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5478) Pentapeptide_4 PF13599.6 ETO06410.1 - 0.42 10.8 6.6 0.69 10.1 1.3 3.7 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO06410.1 - 7.8 6.6 22.4 83 3.3 0.0 8.9 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat Phospholip_B PF04916.13 ETO06411.1 - 2.4e-30 105.6 0.5 2.9e-30 105.4 0.5 1.0 1 0 0 1 1 1 1 Phospholipase B HEAT_2 PF13646.6 ETO06412.1 - 8.5e-18 64.5 0.0 0.012 16.0 0.0 6.1 3 2 3 6 6 6 5 HEAT repeats HEAT PF02985.22 ETO06412.1 - 2.2e-17 61.7 0.3 0.0091 16.2 0.0 8.6 8 1 1 9 9 9 4 HEAT repeat HEAT_EZ PF13513.6 ETO06412.1 - 1.4e-07 31.9 0.0 17 6.1 0.0 6.7 6 2 2 8 8 8 0 HEAT-like repeat Cnd1 PF12717.7 ETO06412.1 - 7.2e-07 29.4 21.4 0.00038 20.6 0.4 5.2 2 1 3 5 5 5 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO06412.1 - 0.00013 22.4 8.7 0.26 11.9 0.0 5.1 2 1 2 5 5 5 2 Vacuolar 14 Fab1-binding region DUF2543 PF10820.8 ETO06412.1 - 0.0031 17.6 1.5 0.52 10.5 0.1 3.5 2 1 1 3 3 3 1 Protein of unknown function (DUF2543) DNA_pol3_gamma3 PF12169.8 ETO06412.1 - 0.025 14.5 0.0 23 4.9 0.0 4.3 4 1 1 5 5 5 0 DNA polymerase III subunits gamma and tau domain III OrfB_IS605 PF01385.19 ETO06412.1 - 0.042 14.1 1.3 0.83 9.9 0.0 2.7 2 0 0 2 2 2 0 Probable transposase Imm30 PF15565.6 ETO06412.1 - 0.054 13.6 14.0 3.3 7.8 1.7 4.8 2 2 1 4 4 4 0 Immunity protein 30 ANAPC3 PF12895.7 ETO06412.1 - 0.079 13.2 0.9 3.8 7.8 0.0 3.7 4 0 0 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SAC3_GANP PF03399.16 ETO06412.1 - 0.2 11.0 10.8 0.4 10.0 0.1 4.4 4 2 2 6 6 6 0 SAC3/GANP family TAN PF11640.8 ETO06412.1 - 0.22 11.7 15.3 9.5 6.3 2.5 5.6 1 1 2 5 5 5 0 Telomere-length maintenance and DNA damage repair PLN_propep PF16485.5 ETO06412.1 - 0.57 9.9 6.8 0.26 11.1 0.2 3.0 3 0 0 3 3 3 0 Protealysin propeptide BRF1 PF07741.13 ETO06415.1 - 0.053 13.9 0.4 0.11 12.8 0.4 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain WD40 PF00400.32 ETO06416.1 - 3.5e-15 56.1 0.5 1.5e-10 41.4 0.1 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06416.1 - 2.3e-06 27.8 0.1 8.9e-06 25.9 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide PF00805.22 ETO06416.1 - 0.00025 20.6 3.0 0.00025 20.6 3.0 2.2 2 1 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO06416.1 - 0.014 15.5 2.1 0.014 15.5 2.1 2.3 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) CppA_N PF14506.6 ETO06416.1 - 0.5 10.5 5.0 6.7 6.8 0.5 2.6 2 0 0 2 2 2 0 CppA N-terminal Pentapeptide_3 PF13576.6 ETO06416.1 - 0.6 10.3 3.3 2.3 8.4 3.3 1.9 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) TPR_12 PF13424.6 ETO06417.1 - 3.5e-67 222.7 10.0 4.7e-17 62.0 1.7 6.7 3 2 4 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06417.1 - 1.9e-45 151.5 0.0 7.1e-07 28.9 0.1 9.1 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06417.1 - 5.2e-34 113.8 2.5 0.00021 21.1 0.0 8.6 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06417.1 - 7.2e-33 111.1 33.5 1.3e-06 28.0 1.7 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06417.1 - 4e-28 95.3 40.6 7.5e-05 22.6 1.2 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06417.1 - 5.2e-27 91.8 26.3 1.1e-05 25.2 0.3 9.4 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06417.1 - 5.2e-11 42.0 19.7 0.00061 19.4 0.1 7.4 8 0 0 8 8 8 3 TPR repeat TPR_14 PF13428.6 ETO06417.1 - 6e-10 39.1 0.0 0.57 11.1 0.0 6.7 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO06417.1 - 1.5e-08 34.4 0.0 0.0069 15.8 0.0 3.0 1 1 2 3 3 3 3 MalT-like TPR region TPR_17 PF13431.6 ETO06417.1 - 1.7e-06 28.0 8.4 9 6.9 0.1 8.3 10 0 0 10 10 8 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06417.1 - 1.6e-05 25.4 0.0 2.5 8.8 0.0 4.5 3 1 0 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO06417.1 - 0.00012 21.9 15.0 7 6.4 0.1 6.8 5 1 2 7 7 7 1 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO06417.1 - 0.00054 20.4 0.1 31 5.2 0.1 5.5 5 1 2 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06417.1 - 0.0048 17.5 5.3 47 4.9 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat Peptidase_C50 PF03568.17 ETO06417.1 - 0.014 14.6 3.0 0.035 13.2 3.0 1.6 1 0 0 1 1 1 0 Peptidase family C50 TPR_21 PF09976.9 ETO06417.1 - 0.038 13.7 1.4 15 5.2 0.0 3.7 3 1 0 4 4 4 0 Tetratricopeptide repeat-like domain NRBF2_MIT PF17169.4 ETO06417.1 - 0.085 13.1 3.2 16 5.8 0.2 3.9 2 1 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 TPR_4 PF07721.14 ETO06417.1 - 0.25 12.1 0.0 40 5.3 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat Collagen_bind_2 PF12904.7 ETO06417.1 - 0.27 11.2 3.8 13 5.8 0.1 3.6 3 0 0 3 3 3 0 Putative collagen-binding domain of a collagenase UPF0370 PF13980.6 ETO06417.1 - 0.3 11.1 3.2 15 5.7 0.1 3.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) DUF4810 PF16068.5 ETO06417.1 - 1 10.0 3.8 19 5.9 0.4 3.7 4 0 0 4 4 2 0 Domain of unknown function (DUF4810) PPR PF01535.20 ETO06417.1 - 6.6 7.2 6.3 28 5.2 0.3 4.7 5 0 0 5 5 4 0 PPR repeat PAP2_3 PF14378.6 ETO06418.1 - 0.0029 17.3 2.7 0.081 12.6 1.0 2.3 2 0 0 2 2 2 2 PAP2 superfamily Phtf-FEM1B_bdg PF12129.8 ETO06418.1 - 0.17 11.7 4.3 0.47 10.3 0.8 2.8 3 0 0 3 3 3 0 Male germ-cell putative homeodomain transcription factor Orf78 PF06024.12 ETO06418.1 - 0.44 10.9 5.3 18 5.7 0.0 3.6 4 1 1 5 5 5 0 Orf78 (ac78) PTR2 PF00854.21 ETO06419.1 - 9e-25 87.3 2.5 1.3e-24 86.8 2.5 1.2 1 0 0 1 1 1 1 POT family DUF4118 PF13493.6 ETO06419.1 - 0.028 14.2 3.3 0.62 9.9 1.8 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4118) DUF1435 PF07256.12 ETO06419.1 - 0.74 9.9 0.1 0.74 9.9 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1435) TFIIA PF03153.13 ETO06420.1 - 0.053 13.5 23.1 0.065 13.2 23.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_12 PF13087.6 ETO06421.1 - 1.1e-62 211.2 0.0 1.1e-62 211.2 0.0 2.3 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ETO06421.1 - 6.7e-14 52.3 0.1 6.7e-14 52.3 0.1 3.2 2 1 0 2 2 2 1 AAA domain Cation_ATPase_N PF00690.26 ETO06422.1 - 0.047 13.4 0.1 0.1 12.3 0.1 1.6 1 0 0 1 1 1 0 Cation transporter/ATPase, N-terminus ETRAMP PF09716.10 ETO06423.1 - 0.34 11.0 2.0 20 5.3 0.2 2.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ras PF00071.22 ETO06425.1 - 1.3e-14 54.1 0.1 1e-13 51.2 0.0 2.2 2 1 1 3 3 3 1 Ras family KHA PF11834.8 ETO06426.1 - 0.0024 17.9 0.1 0.0042 17.1 0.1 1.4 1 0 0 1 1 1 1 KHA, dimerisation domain of potassium ion channel Par3_HAL_N_term PF12053.8 ETO06427.1 - 3.8 7.8 6.4 4.5 7.6 0.5 3.5 3 0 0 3 3 3 0 N-terminal of Par3 and HAL proteins PH PF00169.29 ETO06428.1 - 1.9e-07 31.5 0.5 3.6e-07 30.6 0.5 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO06428.1 - 0.0011 19.3 1.9 0.0036 17.7 0.2 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain PH_9 PF15410.6 ETO06428.1 - 0.011 16.1 0.4 0.021 15.2 0.4 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain Herpes_UL3 PF03369.13 ETO06428.1 - 0.062 13.8 0.0 0.1 13.1 0.0 1.4 1 0 0 1 1 1 0 Herpesvirus UL3 protein Ribosomal_S9 PF00380.19 ETO06429.1 - 3.7e-28 98.5 0.0 7.3e-28 97.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein S9/S16 CBM9_1 PF06452.11 ETO06431.1 - 0.0027 17.7 0.8 0.0065 16.4 0.7 1.5 1 1 0 1 1 1 1 Carbohydrate family 9 binding domain-like SET PF00856.28 ETO06432.1 - 6.4e-11 42.9 1.0 2.1e-10 41.3 1.0 1.7 1 1 0 1 1 1 1 SET domain Orf78 PF06024.12 ETO06432.1 - 0.019 15.2 0.2 0.028 14.7 0.2 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DUF3377 PF11857.8 ETO06432.1 - 0.02 14.8 0.0 0.035 14.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) DAO PF01266.24 ETO06433.1 - 3.8e-10 39.9 0.0 6.8e-10 39.0 0.0 1.5 1 1 0 1 1 1 1 FAD dependent oxidoreductase Myco_arth_vir_N PF09610.10 ETO06433.1 - 0.88 9.7 2.1 1.4 9.1 2.1 1.3 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) DAO PF01266.24 ETO06434.1 - 4.9e-32 111.9 0.0 6.2e-32 111.6 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETO06434.1 - 6.1e-07 28.9 0.0 7.2e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Thi4 family NAD_binding_8 PF13450.6 ETO06434.1 - 8.1e-05 22.8 0.0 0.00013 22.2 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 ETO06434.1 - 0.001 17.8 0.0 0.0013 17.4 0.0 1.1 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) FAD_binding_2 PF00890.24 ETO06434.1 - 0.0027 16.9 0.1 0.0037 16.4 0.1 1.1 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ETO06434.1 - 0.0059 15.9 0.1 0.0084 15.4 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETO06434.1 - 0.0076 15.3 0.0 0.01 14.9 0.0 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein Pyr_redox_2 PF07992.14 ETO06434.1 - 0.0088 15.3 0.0 0.0098 15.2 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO06434.1 - 0.016 14.4 0.0 0.023 13.8 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) TrkA_N PF02254.18 ETO06434.1 - 0.044 14.1 0.1 0.091 13.0 0.1 1.5 1 0 0 1 1 1 0 TrkA-N domain Sacchrp_dh_NADP PF03435.18 ETO06434.1 - 0.055 13.7 0.1 0.098 12.9 0.1 1.4 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain FAD_binding_3 PF01494.19 ETO06434.1 - 0.076 12.2 0.0 0.099 11.9 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain HI0933_like PF03486.14 ETO06434.1 - 0.17 10.6 0.0 0.19 10.4 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein DUF2407_C PF13373.6 ETO06436.1 - 0.0031 17.7 0.0 0.0031 17.7 0.0 2.5 4 0 0 4 4 4 1 DUF2407 C-terminal domain zf_UBZ PF18439.1 ETO06436.1 - 0.0081 15.7 2.6 0.047 13.3 0.1 2.6 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger CFIA_Pcf11 PF11526.8 ETO06436.1 - 0.11 13.0 0.2 0.11 13.0 0.2 4.9 4 1 1 5 5 5 0 Subunit of cleavage factor IA Pcf11 zf-C2H2_jaz PF12171.8 ETO06436.1 - 0.11 12.8 0.7 0.52 10.7 0.7 2.2 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding Shisa PF13908.6 ETO06436.1 - 1.6 8.9 9.7 1.5 9.0 7.4 2.3 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator G-alpha PF00503.20 ETO06438.1 - 4.9e-17 62.1 0.6 4.5e-12 45.8 0.4 2.8 2 1 0 2 2 2 2 G-protein alpha subunit TFIIA PF03153.13 ETO06438.1 - 0.0033 17.5 7.9 0.0033 17.5 7.9 1.9 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Arf PF00025.21 ETO06438.1 - 0.0061 16.0 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Spore_coat_CotO PF14153.6 ETO06438.1 - 0.12 12.3 11.0 0.23 11.4 11.0 1.4 1 0 0 1 1 1 0 Spore coat protein CotO NOA36 PF06524.12 ETO06438.1 - 2 7.7 13.1 4.2 6.6 13.1 1.5 1 0 0 1 1 1 0 NOA36 protein SSP160 PF06933.11 ETO06438.1 - 2.7 6.1 9.6 4.2 5.4 9.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4746 PF15928.5 ETO06438.1 - 7.6 5.9 12.9 15 4.9 12.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TRAP_alpha PF03896.16 ETO06438.1 - 8.2 5.5 8.0 19 4.4 8.0 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sulfotransfer_2 PF03567.14 ETO06439.1 - 0.0037 17.2 0.0 0.0046 16.9 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase family DUF1348 PF07080.11 ETO06440.1 - 0.044 13.7 0.5 6.7 6.6 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1348) DIX PF00778.17 ETO06442.1 - 0.31 10.9 3.7 0.19 11.6 0.3 2.1 2 0 0 2 2 2 0 DIX domain Beach PF02138.18 ETO06443.1 - 5.1e-121 403.3 0.1 7.3e-121 402.8 0.1 1.2 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.21 ETO06443.1 - 5.9e-19 68.0 8.1 5.9e-19 68.0 8.1 1.8 2 0 0 2 2 2 1 FYVE zinc finger WD40 PF00400.32 ETO06443.1 - 1.6e-13 50.8 11.9 7.3e-07 29.8 0.2 4.9 4 0 0 4 4 4 3 WD domain, G-beta repeat IBR PF01485.21 ETO06443.1 - 0.00047 20.3 7.4 0.0016 18.7 7.4 1.9 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain ANAPC4_WD40 PF12894.7 ETO06443.1 - 0.00063 20.0 3.5 0.046 14.0 0.2 3.8 3 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain FYVE_2 PF02318.16 ETO06443.1 - 0.23 11.7 5.3 0.24 11.6 3.5 1.9 2 0 0 2 2 2 0 FYVE-type zinc finger RNA_POL_M_15KD PF02150.16 ETO06443.1 - 5.2 7.0 6.1 13 5.7 6.1 1.8 1 0 0 1 1 1 0 RNA polymerases M/15 Kd subunit PH_BEACH PF14844.6 ETO06444.1 - 7.4e-10 38.8 0.4 7.4e-10 38.8 0.4 2.8 4 0 0 4 4 4 1 PH domain associated with Beige/BEACH SpoU_methylase PF00588.19 ETO06445.1 - 0.03 14.5 0.0 0.047 13.8 0.0 1.4 1 0 0 1 1 1 0 SpoU rRNA Methylase family FTO_NTD PF12933.7 ETO06445.1 - 0.08 12.2 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 FTO catalytic domain DUF3139 PF11337.8 ETO06447.1 - 0.21 12.3 3.3 4.5 8.0 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) GrpE PF01025.19 ETO06448.1 - 2.3e-32 111.9 0.1 2.6e-32 111.8 0.1 1.0 1 0 0 1 1 1 1 GrpE tRNA_edit PF04073.15 ETO06449.1 - 2.8e-31 108.1 0.0 3.5e-31 107.8 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain HGTP_anticodon PF03129.20 ETO06449.1 - 0.068 13.3 0.1 0.17 12.1 0.1 1.6 1 0 0 1 1 1 0 Anticodon binding domain Phage_CII PF05269.11 ETO06449.1 - 0.13 12.4 0.6 5.5 7.3 0.2 2.7 2 1 1 3 3 3 0 Bacteriophage CII protein Ank_4 PF13637.6 ETO06450.1 - 0.00031 21.2 0.9 0.001 19.6 0.2 2.2 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO06450.1 - 0.0011 19.3 0.5 12 6.5 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETO06450.1 - 0.0017 18.7 2.3 0.029 14.9 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 ETO06450.1 - 0.0027 18.3 0.3 0.014 16.0 0.1 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Pilin_PilX PF11530.8 ETO06451.1 - 0.04 13.9 0.6 0.22 11.4 0.1 2.2 2 1 0 2 2 2 0 Minor type IV pilin, PilX AAA_12 PF13087.6 ETO06451.1 - 0.068 12.8 5.7 0.24 11.0 3.3 2.2 1 1 1 2 2 2 0 AAA domain CTP_transf_like PF01467.26 ETO06452.1 - 8e-26 90.9 0.7 1.3e-11 44.9 0.3 2.3 2 0 0 2 2 2 2 Cytidylyltransferase-like GEMIN8 PF15348.6 ETO06452.1 - 0.0004 20.8 6.4 0.072 13.4 5.0 2.5 2 0 0 2 2 2 1 Gemini of Cajal bodies-associated protein 8 Cellulose_synt PF03552.14 ETO06452.1 - 0.015 13.8 0.9 0.021 13.4 0.9 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF3245 PF11595.8 ETO06452.1 - 0.019 15.5 14.7 0.019 15.5 14.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) FAM176 PF14851.6 ETO06452.1 - 0.11 12.2 5.3 0.27 10.9 5.3 1.7 1 0 0 1 1 1 0 FAM176 family Zip PF02535.22 ETO06452.1 - 0.14 11.4 7.5 0.4 9.9 6.2 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter PBP_sp32 PF07222.12 ETO06452.1 - 0.26 10.7 4.3 0.45 9.9 4.3 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PPL5 PF18168.1 ETO06452.1 - 0.26 10.5 9.2 0.36 10.1 8.4 1.6 2 0 0 2 2 2 0 Prim-pol family 5 BSMAP PF12280.8 ETO06452.1 - 0.45 10.7 3.7 0.89 9.7 3.7 1.4 1 0 0 1 1 1 0 Brain specific membrane anchored protein PBP1_TM PF14812.6 ETO06452.1 - 0.52 10.7 10.2 1.7 9.0 10.2 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Presenilin PF01080.17 ETO06452.1 - 0.79 8.4 7.9 1.1 7.9 7.9 1.2 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 ETO06452.1 - 1.6 9.2 8.8 2.7 8.4 8.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF913 PF06025.12 ETO06452.1 - 1.6 7.6 5.5 2.5 7.0 5.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FYDLN_acid PF09538.10 ETO06452.1 - 1.6 9.4 14.0 0.13 12.9 8.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Atrophin-1 PF03154.15 ETO06452.1 - 2.4 6.3 7.7 3.4 5.8 7.7 1.1 1 0 0 1 1 1 0 Atrophin-1 family PIEZO PF15917.5 ETO06452.1 - 3 7.3 12.0 0.092 12.2 4.9 1.9 2 0 0 2 2 2 0 Piezo Neur_chan_memb PF02932.16 ETO06452.1 - 3.9 7.5 6.4 0.76 9.8 3.0 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 ETO06452.1 - 6 6.5 9.1 12 5.6 9.1 1.4 1 0 0 1 1 1 0 Connexin zf-CCCH PF00642.24 ETO06453.1 - 5.7e-13 48.4 20.9 8e-12 44.8 1.1 4.0 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO06453.1 - 4.1e-09 36.0 8.5 3.2e-05 23.6 1.9 2.7 2 0 0 2 2 2 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETO06453.1 - 2.7e-07 30.4 19.9 1.2e-06 28.4 4.3 3.6 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_2 PF14608.6 ETO06453.1 - 1.1e-05 25.7 13.9 0.00091 19.6 1.8 3.6 3 0 0 3 3 3 2 RNA-binding, Nab2-type zinc finger Torus PF16131.5 ETO06453.1 - 0.026 15.2 5.3 0.026 15.2 5.3 2.6 1 1 1 2 2 2 0 Torus domain TPR_12 PF13424.6 ETO06454.1 - 1.1e-21 76.8 0.2 7.3e-11 42.2 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06454.1 - 3.2e-17 61.2 7.2 8.6e-05 22.5 1.3 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06454.1 - 4.8e-17 61.0 10.5 1.1e-06 28.2 2.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06454.1 - 1.3e-16 59.8 0.1 3e-06 26.9 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06454.1 - 1.7e-16 58.9 0.7 6.5e-06 25.8 0.1 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06454.1 - 3.6e-12 45.4 6.1 0.00055 19.9 0.8 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO06454.1 - 1.4e-06 28.5 0.4 4.1e-06 26.9 0.4 1.8 1 1 0 1 1 1 1 Caspase domain TPR_17 PF13431.6 ETO06454.1 - 2.8e-06 27.3 2.0 0.31 11.5 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06454.1 - 0.00052 20.5 0.7 1.1 10.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06454.1 - 0.00059 19.5 6.8 1.4 8.6 0.1 4.6 3 2 2 5 5 5 2 TPR repeat TPR_14 PF13428.6 ETO06454.1 - 0.0021 18.7 0.1 5.3 8.1 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06454.1 - 0.17 12.5 0.0 17 6.1 0.0 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO06454.1 - 0.23 11.1 3.5 0.63 9.7 0.2 2.4 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETO06454.1 - 0.39 10.5 3.2 15 5.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) PPR PF01535.20 ETO06454.1 - 0.42 11.0 2.4 8.1 6.9 0.0 3.6 4 0 0 4 4 4 0 PPR repeat MIT PF04212.18 ETO06454.1 - 0.83 9.8 5.0 8.5 6.5 0.7 3.3 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain LRR_8 PF13855.6 ETO06456.1 - 4.4e-08 32.8 27.1 0.0016 18.2 2.4 5.3 2 1 3 5 5 5 4 Leucine rich repeat LRR_4 PF12799.7 ETO06456.1 - 1.2e-05 25.6 32.1 0.00067 20.0 2.4 5.9 5 1 2 7 7 7 4 Leucine Rich repeats (2 copies) FNIP PF05725.12 ETO06456.1 - 0.00016 21.8 0.0 0.58 10.4 0.0 4.8 3 2 0 3 3 3 1 FNIP Repeat LRR_1 PF00560.33 ETO06456.1 - 0.0099 16.3 16.7 7.4 7.5 0.1 6.9 7 0 0 7 7 7 2 Leucine Rich Repeat LRR_6 PF13516.6 ETO06456.1 - 0.75 10.0 7.8 9 6.6 0.2 4.5 4 0 0 4 4 4 0 Leucine Rich repeat LRR_4 PF12799.7 ETO06458.1 - 3e-08 33.8 19.4 0.0094 16.4 2.1 4.8 4 1 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO06458.1 - 1.5e-06 27.9 15.3 0.0036 17.0 0.6 4.6 1 1 3 4 4 4 4 Leucine rich repeat LRR_9 PF14580.6 ETO06458.1 - 0.012 15.1 0.4 3 7.3 0.3 2.5 1 1 0 1 1 1 0 Leucine-rich repeat LRR_1 PF00560.33 ETO06458.1 - 0.018 15.5 13.8 7.4 7.6 0.1 5.6 4 1 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 ETO06458.1 - 0.019 15.0 14.4 16 5.8 0.0 7.0 7 0 0 7 7 7 0 Leucine Rich repeat FAD_binding_4 PF01565.23 ETO06459.1 - 0.0077 16.0 0.0 0.011 15.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain WD40 PF00400.32 ETO06461.1 - 4e-16 59.1 16.9 7.3e-07 29.8 2.8 5.2 4 1 1 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO06461.1 - 5.3e-05 22.1 2.2 0.0064 15.2 0.4 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO06461.1 - 0.00044 20.9 2.1 0.00044 20.9 2.1 2.7 2 1 0 2 2 2 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO06461.1 - 0.0045 17.3 1.0 0.054 13.8 0.1 2.8 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06461.1 - 0.046 13.0 0.3 0.046 13.0 0.3 2.9 1 1 2 3 3 3 0 WD40-like domain DUF2746 PF10874.8 ETO06461.1 - 0.21 12.0 2.9 27 5.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2746) FapA PF03961.13 ETO06461.1 - 0.46 9.0 13.8 0.65 8.5 13.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-MIZ PF02891.20 ETO06461.1 - 2.8 7.7 7.5 0.16 11.8 1.1 2.2 2 0 0 2 2 2 0 MIZ/SP-RING zinc finger DivIC PF04977.15 ETO06461.1 - 3.9 7.3 21.8 8.2 6.3 7.0 2.8 1 1 1 2 2 2 0 Septum formation initiator DUF2884 PF11101.8 ETO06462.1 - 0.073 12.6 0.1 7 6.1 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF2884) DUF4132 PF13569.6 ETO06463.1 - 0.0064 16.3 1.1 0.0079 16.0 1.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4132) CUE PF02845.16 ETO06464.1 - 0.00052 19.7 0.2 0.0035 17.0 0.0 2.5 2 0 0 2 2 2 1 CUE domain SLED PF12140.8 ETO06464.1 - 0.13 12.8 1.3 0.5 10.9 0.2 2.1 2 0 0 2 2 2 0 SLED domain DUF4373 PF14297.6 ETO06464.1 - 0.2 12.5 0.4 0.2 12.5 0.4 2.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4373) Asp PF00026.23 ETO06465.1 - 1.2e-37 130.1 0.2 1.5e-37 129.7 0.2 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease LAT PF15234.6 ETO06465.1 - 0.44 10.2 3.2 0.71 9.6 3.2 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells MgtE PF01769.16 ETO06466.1 - 0.032 14.6 0.9 0.055 13.9 0.9 1.3 1 0 0 1 1 1 0 Divalent cation transporter UL17 PF17640.2 ETO06466.1 - 0.21 11.6 0.0 0.21 11.6 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized UL17 Ndc1_Nup PF09531.10 ETO06466.1 - 3.2 6.3 9.7 4.3 5.9 9.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AzlD PF05437.12 ETO06467.1 - 0.0081 16.3 0.8 0.03 14.5 0.4 2.1 2 0 0 2 2 2 1 Branched-chain amino acid transport protein (AzlD) DUF3328 PF11807.8 ETO06467.1 - 0.089 12.6 0.6 0.8 9.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Orf78 PF06024.12 ETO06467.1 - 1 9.7 0.0 1 9.7 0.0 3.5 3 1 1 4 4 4 0 Orf78 (ac78) Pox_polyA_pol_N PF12630.7 ETO06467.1 - 2.7 8.4 7.4 0.11 12.8 1.0 1.9 2 0 0 2 2 2 0 Poxvirus poly(A) polymerase N-terminal domain Ribosomal_L17 PF01196.19 ETO06468.1 - 0.015 16.2 0.1 0.023 15.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L17 BcrAD_BadFG PF01869.20 ETO06468.1 - 0.11 12.0 0.0 0.14 11.7 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Thioredoxin_16 PF18569.1 ETO06469.1 - 0.046 13.9 0.9 0.34 11.1 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain HA2 PF04408.23 ETO06470.1 - 5.7e-15 55.5 0.1 5.7e-15 55.5 0.1 2.5 2 1 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETO06470.1 - 1.9e-11 44.3 0.0 3.1e-10 40.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain U3_snoRNA_assoc PF08297.11 ETO06470.1 - 0.33 11.7 11.2 0.055 14.2 4.6 2.5 1 1 1 2 2 2 0 U3 snoRNA associated PH_4 PF15404.6 ETO06470.1 - 0.5 10.2 6.4 0.51 10.1 3.7 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DEAD PF00270.29 ETO06471.1 - 1.6e-06 28.0 0.1 7.5e-06 25.8 0.1 1.9 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO06471.1 - 0.0001 22.6 0.0 0.00021 21.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 ETO06471.1 - 0.0032 16.9 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 KaiC FtsK_SpoIIIE PF01580.18 ETO06471.1 - 0.027 13.8 0.0 0.043 13.2 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_25 PF13481.6 ETO06471.1 - 0.027 14.0 0.0 0.1 12.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO06471.1 - 0.034 13.9 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO06471.1 - 0.04 14.4 0.1 0.11 13.0 0.0 1.8 2 0 0 2 2 2 0 ABC transporter T2SSE PF00437.20 ETO06471.1 - 0.09 11.8 0.0 0.15 11.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein PhoH PF02562.16 ETO06471.1 - 0.094 12.2 0.0 0.18 11.2 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_5 PF07728.14 ETO06471.1 - 0.11 12.5 0.1 25 4.9 0.0 3.0 3 1 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ETO06471.1 - 0.12 12.6 0.0 0.18 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO06471.1 - 0.12 12.9 0.4 0.12 12.9 0.4 2.0 2 1 0 2 2 2 0 AAA domain Glyco_hydro_79n PF03662.14 ETO06472.1 - 0.012 14.6 0.6 0.019 13.9 0.1 1.5 2 0 0 2 2 2 0 Glycosyl hydrolase family 79, N-terminal domain SOGA PF11365.8 ETO06473.1 - 0.0021 19.2 6.2 0.063 14.4 0.1 2.1 1 1 1 2 2 2 1 Protein SOGA GAS PF13851.6 ETO06473.1 - 0.012 15.0 12.0 0.021 14.2 12.0 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 ETO06473.1 - 0.014 14.9 9.1 0.015 14.8 9.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Tugs PF17840.1 ETO06473.1 - 0.016 15.4 2.0 0.22 11.7 0.0 2.6 2 0 0 2 2 2 0 Tethering Ubl4a to BAGS domain Troponin PF00992.20 ETO06473.1 - 0.022 15.0 8.5 0.073 13.4 5.7 2.1 1 1 1 2 2 2 0 Troponin Phage_GP20 PF06810.11 ETO06473.1 - 0.045 13.5 8.7 1.1 9.1 1.3 2.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 bZIP_1 PF00170.21 ETO06473.1 - 0.051 13.7 6.7 2.6 8.2 2.9 2.4 2 0 0 2 2 2 0 bZIP transcription factor Hepsin-SRCR PF09272.10 ETO06473.1 - 0.059 13.9 0.5 0.11 13.0 0.5 1.4 1 1 0 1 1 1 0 Hepsin, SRCR domain LINES_C PF14695.6 ETO06473.1 - 0.069 12.6 0.3 0.17 11.4 0.3 1.6 1 0 0 1 1 1 0 Lines C-terminus Cytochrom_B562 PF07361.11 ETO06473.1 - 0.1 13.3 4.3 0.18 12.5 4.3 1.6 1 1 0 1 1 1 0 Cytochrome b562 FapA PF03961.13 ETO06473.1 - 0.17 10.5 6.4 0.2 10.2 6.4 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Cnn_1N PF07989.11 ETO06473.1 - 0.19 11.9 10.8 2.7 8.2 6.5 2.3 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Atg14 PF10186.9 ETO06473.1 - 0.23 10.5 12.0 0.42 9.7 12.0 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PRKG1_interact PF15898.5 ETO06473.1 - 0.27 12.1 10.6 0.095 13.6 8.1 1.5 2 0 0 2 2 1 0 cGMP-dependent protein kinase interacting domain Cep57_CLD_2 PF14197.6 ETO06473.1 - 0.28 11.3 6.6 0.38 10.9 0.1 2.5 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 THOC7 PF05615.13 ETO06473.1 - 0.38 11.0 10.2 0.96 9.7 10.1 1.7 1 1 0 1 1 1 0 Tho complex subunit 7 FliD_N PF02465.18 ETO06473.1 - 0.93 10.2 10.4 0.63 10.8 7.4 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Uso1_p115_C PF04871.13 ETO06473.1 - 1.4 9.3 11.3 1.3 9.4 9.9 1.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region EMC3_TMCO1 PF01956.16 ETO06473.1 - 2.2 8.0 5.9 0.34 10.6 2.2 1.5 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF3450 PF11932.8 ETO06473.1 - 4.9 6.4 16.7 4.7 6.5 10.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) HR1 PF02185.16 ETO06473.1 - 5.7 7.1 14.1 5.1 7.3 9.9 2.3 1 1 1 2 2 2 0 Hr1 repeat DUF4446 PF14584.6 ETO06473.1 - 6.2 6.8 7.6 18 5.3 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DHHC PF01529.20 ETO06476.1 - 3e-31 108.3 18.7 3e-31 108.3 18.7 2.7 2 0 0 2 2 2 1 DHHC palmitoyltransferase DUF2685 PF10886.8 ETO06476.1 - 0.034 14.3 1.0 0.034 14.3 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2685) Dynein_IC2 PF11540.8 ETO06476.1 - 0.12 12.3 1.0 0.25 11.3 1.0 1.5 1 0 0 1 1 1 0 Cytoplasmic dynein 1 intermediate chain 2 IMS PF00817.20 ETO06478.1 - 1.7e-20 73.6 0.1 4e-20 72.3 0.1 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ETO06478.1 - 3.3e-09 37.5 0.0 1.6e-08 35.2 0.0 2.1 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain REV1_C PF16727.5 ETO06478.1 - 4.5e-09 36.6 0.8 1e-08 35.4 0.1 2.0 2 0 0 2 2 2 1 DNA repair protein REV1 C-terminal domain DNAP_B_exo_N PF08452.10 ETO06478.1 - 0.098 12.1 0.2 0.25 10.8 0.2 1.6 1 0 0 1 1 1 0 DNA polymerase family B exonuclease domain, N-terminal Na_Ca_ex PF01699.24 ETO06479.1 - 1.5e-05 25.0 12.1 3.3e-05 23.9 12.1 1.7 1 1 0 1 1 1 1 Sodium/calcium exchanger protein DUF3169 PF11368.8 ETO06479.1 - 0.016 14.7 9.1 0.017 14.6 3.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) WD40 PF00400.32 ETO06481.1 - 0.27 12.1 6.0 0.76 10.8 0.7 3.3 3 0 0 3 3 3 0 WD domain, G-beta repeat PT PF04886.12 ETO06482.1 - 0.00026 20.4 14.1 0.0022 17.5 0.4 3.1 2 0 0 2 2 2 2 PT repeat DUF2681 PF10883.8 ETO06482.1 - 0.012 16.0 0.9 0.029 14.8 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Dicty_REP PF05086.12 ETO06482.1 - 0.71 7.8 7.2 1.1 7.2 7.2 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SusD-like_3 PF14322.6 ETO06483.1 - 0.067 13.5 0.0 0.1 12.9 0.0 1.3 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Calc_CGRP_IAPP PF00214.19 ETO06483.1 - 0.76 10.2 5.7 0.4 11.1 1.1 2.2 1 1 1 2 2 2 0 Calcitonin / CGRP / IAPP family Phage_Gp23 PF10669.9 ETO06483.1 - 0.99 9.8 9.4 3.1 8.1 5.8 2.4 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) BORCS7 PF16088.5 ETO06484.1 - 0.024 14.9 1.1 0.041 14.2 1.1 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 BRCT PF00533.26 ETO06484.1 - 0.028 14.8 0.2 0.039 14.3 0.2 1.4 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain DUF2541 PF10807.8 ETO06484.1 - 0.12 12.4 1.1 0.21 11.7 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2541) BRCT_2 PF16589.5 ETO06484.1 - 3.4 8.2 9.1 6.2 7.3 8.0 2.2 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Plug_translocon PF10559.9 ETO06485.1 - 5.8e-14 51.6 0.1 2.2e-13 49.8 0.0 1.9 2 0 0 2 2 2 1 Plug domain of Sec61p SecY PF00344.20 ETO06485.1 - 2e-11 43.7 0.2 2.7e-11 43.3 0.2 1.2 1 0 0 1 1 1 1 SecY translocase Asp2 PF16929.5 ETO06486.1 - 0.039 12.9 0.2 0.052 12.5 0.2 1.1 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter Peptidase_S49_N PF08496.10 ETO06488.1 - 0.1 12.7 2.1 0.1 12.6 2.1 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TK PF00265.18 ETO06491.1 - 0.054 13.4 0.5 0.2 11.5 0.2 2.1 2 0 0 2 2 2 0 Thymidine kinase Consortin_C PF15281.6 ETO06492.1 - 0.12 12.4 0.0 0.3 11.1 0.0 1.7 1 1 0 1 1 1 0 Consortin C-terminus NUT PF12881.7 ETO06493.1 - 1.5 7.1 4.9 2 6.7 4.9 1.1 1 0 0 1 1 1 0 NUT protein FlaC_arch PF05377.11 ETO06494.1 - 0.00069 20.0 8.2 0.0051 17.2 0.5 2.2 2 0 0 2 2 2 2 Flagella accessory protein C (FlaC) YrbL-PhoP_reg PF10707.9 ETO06494.1 - 0.032 13.7 1.0 0.034 13.7 1.0 1.0 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL GIT_CC PF16559.5 ETO06494.1 - 1.2 9.0 11.4 0.37 10.7 0.7 2.8 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMCO5 PF14992.6 ETO06494.1 - 2 7.9 13.7 4.4 6.8 13.6 1.5 1 1 0 1 1 1 0 TMCO5 family DUF4446 PF14584.6 ETO06494.1 - 5.7 6.9 7.5 2.7 8.0 0.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) PmoA PF14100.6 ETO06495.1 - 0.082 12.4 1.6 0.087 12.3 1.6 1.1 1 0 0 1 1 1 0 Methane oxygenase PmoA EVC2_like PF12297.8 ETO06495.1 - 0.22 10.2 15.0 0.25 10.0 15.0 1.0 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein DUF3223 PF11523.8 ETO06495.1 - 1.1 10.1 5.9 0.34 11.8 1.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3223) Atg14 PF10186.9 ETO06495.1 - 2 7.4 14.2 2.1 7.3 14.2 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4337 PF14235.6 ETO06495.1 - 7.5 6.6 14.5 7.2 6.7 13.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) RR_TM4-6 PF06459.12 ETO06496.1 - 0.037 13.9 10.5 0.05 13.4 10.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SRP-alpha_N PF04086.13 ETO06496.1 - 0.13 12.2 18.5 0.15 12.0 18.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Presenilin PF01080.17 ETO06496.1 - 0.43 9.3 12.1 0.49 9.1 12.1 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO06496.1 - 0.72 8.8 5.4 0.83 8.6 5.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4551 PF15087.6 ETO06496.1 - 0.78 8.5 13.2 0.88 8.3 13.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ndc1_Nup PF09531.10 ETO06496.1 - 1.2 7.7 11.9 1.5 7.4 11.9 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pol_alpha_B_N PF08418.10 ETO06496.1 - 1.3 8.9 16.0 1.8 8.5 16.0 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal DUF4554 PF15091.6 ETO06496.1 - 1.9 7.3 8.5 2.4 7.0 8.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Mitofilin PF09731.9 ETO06496.1 - 3.8 6.2 16.9 4.6 6.0 16.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NPR3 PF03666.13 ETO06496.1 - 4.5 6.0 16.7 5.6 5.6 16.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 ETO06496.1 - 5.6 5.7 8.7 6.1 5.5 8.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Apt1 PF10351.9 ETO06496.1 - 5.7 5.7 16.7 6.6 5.5 16.7 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Neur_chan_memb PF02932.16 ETO06496.1 - 5.8 6.9 7.7 6.6 6.7 7.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GREB1 PF15782.5 ETO06496.1 - 7.1 3.6 10.4 7.7 3.5 10.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Borrelia_P83 PF05262.11 ETO06496.1 - 7.6 4.9 16.5 8.6 4.7 16.5 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein YL1 PF05764.13 ETO06496.1 - 8.1 6.5 28.5 10 6.1 28.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 ETO06496.1 - 8.2 4.6 14.0 9.7 4.3 14.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF3807 PF12720.7 ETO06496.1 - 8.4 6.6 19.4 11 6.2 19.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) MFS_1 PF07690.16 ETO06497.1 - 2.5e-10 39.8 0.3 3.3e-10 39.4 0.3 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sulf_transp PF04143.14 ETO06497.1 - 0.01 15.4 0.0 0.014 15.0 0.0 1.1 1 0 0 1 1 1 0 Sulphur transport YukC PF10140.9 ETO06497.1 - 0.092 11.6 0.6 0.27 10.0 0.3 1.6 1 1 1 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC PBP1_TM PF14812.6 ETO06497.1 - 0.13 12.6 0.4 0.49 10.8 0.1 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PITH PF06201.13 ETO06498.1 - 5e-12 46.3 4.1 1e-11 45.3 3.7 1.7 1 1 0 1 1 1 1 PITH domain FAM176 PF14851.6 ETO06498.1 - 0.0068 16.1 1.6 0.011 15.3 1.6 1.4 1 0 0 1 1 1 1 FAM176 family NOA36 PF06524.12 ETO06498.1 - 0.033 13.5 3.0 0.046 13.1 3.0 1.3 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO06498.1 - 0.18 12.2 9.4 0.35 11.3 9.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Vps52 PF04129.12 ETO06499.1 - 1.6e-20 73.4 0.4 1.6e-20 73.4 0.4 1.5 2 0 0 2 2 2 1 Vps52 / Sac2 family Exo70 PF03081.15 ETO06499.1 - 0.015 14.3 5.0 0.017 14.2 4.2 1.4 1 1 0 1 1 1 0 Exo70 exocyst complex subunit DnaG_DnaB_bind PF08278.11 ETO06499.1 - 0.042 14.4 0.3 0.19 12.3 0.0 2.1 2 1 0 2 2 2 0 DNA primase DnaG DnaB-binding DCB PF16213.5 ETO06499.1 - 0.055 13.1 0.6 0.1 12.3 0.2 1.6 1 1 0 1 1 1 0 Dimerisation and cyclophilin-binding domain of Mon2 DASH_Spc19 PF08287.11 ETO06499.1 - 0.058 13.3 1.1 0.24 11.3 0.1 2.2 2 0 0 2 2 2 0 Spc19 DUF3800 PF12686.7 ETO06499.1 - 0.19 12.4 0.7 0.52 10.9 0.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) HSP70 PF00012.20 ETO06501.1 - 3e-134 448.5 7.0 3.6e-102 342.5 2.3 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO06501.1 - 1.5e-07 30.5 0.2 0.0023 16.8 0.2 2.2 2 0 0 2 2 2 2 MreB/Mbl protein Uso1_p115_C PF04871.13 ETO06501.1 - 0.11 12.9 2.0 0.96 9.8 0.2 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Spt5_N PF11942.8 ETO06502.1 - 0.36 11.8 9.4 0.61 11.1 9.4 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CAP_GLY PF01302.25 ETO06503.1 - 0.0037 17.2 0.1 0.0093 16.0 0.1 1.7 1 1 0 1 1 1 1 CAP-Gly domain CCB1 PF12046.8 ETO06503.1 - 0.11 11.8 0.3 0.24 10.7 0.1 1.6 2 0 0 2 2 2 0 Cofactor assembly of complex C subunit B FAD_binding_3 PF01494.19 ETO06504.1 - 0.0027 17.0 0.0 0.027 13.7 0.0 2.1 2 0 0 2 2 2 1 FAD binding domain AAA PF00004.29 ETO06506.1 - 1.4e-17 64.3 0.0 8.8e-17 61.8 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) LON_substr_bdg PF02190.16 ETO06506.1 - 7.9e-07 29.2 0.1 7.9e-07 29.2 0.1 2.5 2 1 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain AAA_22 PF13401.6 ETO06506.1 - 7.2e-06 26.3 0.1 0.00024 21.4 0.1 3.1 1 1 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ETO06506.1 - 5.7e-05 23.3 3.1 0.0001 22.5 0.0 2.8 4 0 0 4 4 3 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ETO06506.1 - 9.6e-05 22.4 0.4 0.00039 20.4 0.0 2.4 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO06506.1 - 0.00045 20.6 2.9 0.0024 18.3 0.1 3.2 3 2 0 3 3 3 1 AAA ATPase domain SR-25 PF10500.9 ETO06506.1 - 0.00063 19.4 9.0 0.00063 19.4 9.0 2.2 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein RNA_helicase PF00910.22 ETO06506.1 - 0.0014 19.0 1.6 0.093 13.1 0.0 3.8 4 0 0 4 4 4 1 RNA helicase NTPase_1 PF03266.15 ETO06506.1 - 0.0026 17.7 0.0 1.4 8.8 0.0 3.3 3 0 0 3 3 3 1 NTPase AAA_14 PF13173.6 ETO06506.1 - 0.0091 16.0 0.0 0.039 14.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain CENP-X PF09415.10 ETO06506.1 - 0.012 16.0 0.1 1.1 9.6 0.0 3.2 2 0 0 2 2 2 0 CENP-S associating Centromere protein X AAA_3 PF07726.11 ETO06506.1 - 0.014 15.3 0.0 0.039 13.8 0.0 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ETO06506.1 - 0.017 14.9 0.1 0.11 12.2 0.0 2.4 2 1 0 2 2 2 0 IstB-like ATP binding protein Secretin_N_2 PF07655.13 ETO06506.1 - 0.02 15.4 23.8 0.024 15.2 6.7 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain TIP49 PF06068.13 ETO06506.1 - 0.023 13.9 0.7 0.039 13.2 0.0 1.7 2 0 0 2 2 2 0 TIP49 P-loop domain Lin-8 PF03353.15 ETO06506.1 - 0.025 14.2 13.0 0.024 14.2 5.1 2.2 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist AAA_30 PF13604.6 ETO06506.1 - 0.026 14.2 0.0 0.078 12.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO06506.1 - 0.027 15.0 0.0 0.027 15.0 0.0 2.8 4 0 0 4 4 2 0 AAA domain RuvB_N PF05496.12 ETO06506.1 - 0.061 13.1 0.1 0.2 11.4 0.0 1.9 2 0 0 2 2 1 0 Holliday junction DNA helicase RuvB P-loop domain ArsA_ATPase PF02374.15 ETO06506.1 - 0.17 11.0 5.0 1.4 8.0 0.0 2.9 3 0 0 3 3 3 0 Anion-transporting ATPase SKI PF01202.22 ETO06506.1 - 0.35 11.0 0.0 0.35 11.0 0.0 2.9 3 0 0 3 3 2 0 Shikimate kinase IMUP PF15761.5 ETO06506.1 - 0.81 10.4 16.1 0.072 13.8 5.6 2.4 2 0 0 2 2 2 0 Immortalisation up-regulated protein AAA_23 PF13476.6 ETO06506.1 - 0.99 9.9 0.0 0.99 9.9 0.0 3.3 1 1 1 3 3 2 0 AAA domain Zip PF02535.22 ETO06506.1 - 2.7 7.1 7.1 0.52 9.5 0.4 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter MRI PF15325.6 ETO06506.1 - 3.4 8.8 9.0 6.3 7.9 2.2 2.4 2 0 0 2 2 2 0 Modulator of retrovirus infection APC_basic PF05956.11 ETO06506.1 - 5.3 6.4 18.1 0.056 12.9 8.6 1.9 2 0 0 2 2 2 0 APC basic domain GAS PF13851.6 ETO06507.1 - 5.3e-05 22.7 36.7 0.0011 18.4 31.0 2.6 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding ZapB PF06005.12 ETO06507.1 - 0.01 16.3 37.5 0.23 11.9 9.5 4.1 1 1 1 3 3 3 0 Cell division protein ZapB Lipocalin_2 PF08212.12 ETO06507.1 - 0.015 15.3 3.1 0.47 10.4 0.4 2.2 2 0 0 2 2 2 0 Lipocalin-like domain BLOC1_2 PF10046.9 ETO06507.1 - 0.017 15.4 4.6 0.017 15.4 4.6 3.6 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4686 PF15742.5 ETO06507.1 - 0.031 13.4 40.0 0.056 12.6 22.8 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF4686) ABC_membrane_2 PF06472.15 ETO06507.1 - 0.05 13.0 2.1 0.057 12.8 1.2 1.5 1 1 0 1 1 1 0 ABC transporter transmembrane region 2 KLRAQ PF10205.9 ETO06507.1 - 0.067 13.4 25.4 0.82 9.9 5.7 3.5 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein DUF4201 PF13870.6 ETO06507.1 - 0.089 12.5 36.7 0.46 10.2 2.2 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) NPV_P10 PF05531.12 ETO06507.1 - 0.11 12.9 15.5 0.16 12.4 0.2 3.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein MAD PF05557.13 ETO06507.1 - 0.12 10.7 33.0 0.16 10.3 33.0 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein ADIP PF11559.8 ETO06507.1 - 0.24 11.5 33.7 0.055 13.6 9.6 2.8 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ETO06507.1 - 0.25 11.6 32.3 0.16 12.2 13.3 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) LPP PF04728.13 ETO06507.1 - 0.25 11.8 7.2 0.24 11.8 1.5 3.3 1 1 2 3 3 3 0 Lipoprotein leucine-zipper Atg14 PF10186.9 ETO06507.1 - 0.26 10.4 22.2 0.43 9.6 21.7 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sec34 PF04136.15 ETO06507.1 - 0.26 11.1 27.9 0.036 14.0 12.1 3.0 1 1 2 3 3 3 0 Sec34-like family Golgin_A5 PF09787.9 ETO06507.1 - 0.33 10.4 32.9 0.069 12.6 14.2 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 DivIC PF04977.15 ETO06507.1 - 0.47 10.2 32.3 0.27 11.0 3.0 4.5 1 1 2 4 4 4 0 Septum formation initiator DUF812 PF05667.11 ETO06507.1 - 0.52 9.1 30.7 0.75 8.6 30.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF812) SYCE1 PF15233.6 ETO06507.1 - 0.55 10.3 36.6 0.84 9.7 15.5 3.1 1 1 2 3 3 3 0 Synaptonemal complex central element protein 1 ERM PF00769.19 ETO06507.1 - 0.68 9.7 32.8 6 6.6 16.9 2.6 1 1 1 2 2 2 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.19 ETO06507.1 - 0.71 7.7 24.9 0.11 10.4 9.5 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Leu_zip PF15294.6 ETO06507.1 - 0.94 8.9 28.9 2.6 7.5 27.3 2.2 1 1 1 2 2 2 0 Leucine zipper Cob_adeno_trans PF01923.18 ETO06507.1 - 1.1 9.4 10.7 2.5 8.2 0.5 2.5 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Fmp27_WPPW PF10359.9 ETO06507.1 - 1.2 7.9 23.7 0.031 13.1 6.6 2.1 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain SlyX PF04102.12 ETO06507.1 - 1.5 9.5 27.6 0.94 10.1 1.6 4.9 1 1 3 4 4 3 0 SlyX TMPIT PF07851.13 ETO06507.1 - 1.7 7.8 26.0 0.83 8.8 10.4 2.2 1 1 1 2 2 2 0 TMPIT-like protein CENP-F_leu_zip PF10473.9 ETO06507.1 - 1.8 8.6 33.8 0.25 11.4 21.5 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4472 PF14739.6 ETO06507.1 - 2.2 9.1 26.7 11 6.8 7.7 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 ETO06507.1 - 2.2 8.8 35.5 3.1 8.3 19.0 3.0 1 1 2 3 3 3 0 Apg6 coiled-coil region HAP1_N PF04849.13 ETO06507.1 - 2.4 7.3 39.0 0.57 9.3 15.9 3.0 1 1 2 3 3 3 0 HAP1 N-terminal conserved region Mod_r PF07200.13 ETO06507.1 - 2.7 8.1 35.3 1 9.5 13.7 2.9 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Rootletin PF15035.6 ETO06507.1 - 3.8 7.5 34.0 7.8 6.5 21.7 3.1 1 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Tropomyosin_1 PF12718.7 ETO06507.1 - 5 7.3 32.9 0.094 12.9 2.8 3.1 1 1 2 3 3 3 0 Tropomyosin like DUF4407 PF14362.6 ETO06507.1 - 6.5 6.0 19.3 16 4.7 19.3 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Seryl_tRNA_N PF02403.22 ETO06507.1 - 8.3 6.7 22.6 0.28 11.4 1.5 2.9 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain ATP-synt_ab PF00006.25 ETO06508.1 - 2.2e-101 338.0 0.0 3.4e-101 337.3 0.0 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_Xtn PF16886.5 ETO06508.1 - 6.1e-41 139.1 0.0 1.3e-40 138.1 0.0 1.6 1 0 0 1 1 1 1 ATPsynthase alpha/beta subunit N-term extension ATP-synt_ab_N PF02874.23 ETO06508.1 - 1.2e-08 35.4 2.2 1.2e-08 35.4 0.5 1.9 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain Mob_Pre PF01076.19 ETO06508.1 - 0.029 14.2 0.3 0.073 12.9 0.3 1.6 1 0 0 1 1 1 0 Plasmid recombination enzyme AAA_18 PF13238.6 ETO06508.1 - 0.12 12.9 0.0 0.35 11.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Nop14 PF04147.12 ETO06509.1 - 0.0039 15.5 6.7 0.0043 15.3 6.7 1.0 1 0 0 1 1 1 1 Nop14-like family BSP_II PF05432.11 ETO06509.1 - 0.011 15.4 12.9 0.038 13.7 13.0 1.7 1 1 1 2 2 2 0 Bone sialoprotein II (BSP-II) CENP-B_dimeris PF09026.10 ETO06509.1 - 0.48 10.8 11.7 1 9.8 11.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Presenilin PF01080.17 ETO06509.1 - 1.6 7.4 5.9 2.3 6.9 5.9 1.3 1 0 0 1 1 1 0 Presenilin Podoplanin PF05808.11 ETO06509.1 - 2.1 8.5 9.2 0.11 12.6 3.7 1.6 2 0 0 2 2 2 0 Podoplanin DNA_pol_phi PF04931.13 ETO06509.1 - 4.1 5.4 16.0 5.3 5.0 16.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO06509.1 - 5.6 5.1 13.9 7.3 4.8 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PIP5K PF01504.18 ETO06510.1 - 2.5e-29 102.4 0.7 7.4e-29 100.8 0.7 1.6 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase OsmC PF02566.19 ETO06511.1 - 0.18 12.3 0.4 0.27 11.8 0.4 1.2 1 0 0 1 1 1 0 OsmC-like protein Pepsin-I3 PF06394.13 ETO06511.1 - 0.18 12.0 3.4 0.16 12.1 1.7 1.7 1 1 0 1 1 1 0 Pepsin inhibitor-3-like repeated domain UPF0242 PF06785.11 ETO06511.1 - 0.8 9.8 12.1 1 9.4 12.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus WD40 PF00400.32 ETO06512.1 - 6.1e-14 52.2 0.9 8.5e-05 23.3 0.0 4.0 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06512.1 - 9.7e-05 22.6 0.1 0.26 11.6 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06512.1 - 0.017 13.8 0.1 0.61 8.7 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 HALZ PF02183.18 ETO06513.1 - 3.6e-05 23.9 11.7 0.012 15.8 1.9 3.6 3 0 0 3 3 3 2 Homeobox associated leucine zipper ERM PF00769.19 ETO06513.1 - 0.00087 19.2 8.8 0.00087 19.2 8.8 2.6 3 0 0 3 3 3 2 Ezrin/radixin/moesin family UPF0242 PF06785.11 ETO06513.1 - 0.0043 17.2 29.8 0.37 10.9 9.5 3.1 1 1 2 3 3 3 2 Uncharacterised protein family (UPF0242) N-terminus YqgF PF14639.6 ETO06513.1 - 0.012 15.4 1.7 0.038 13.8 0.0 2.3 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 CENP-F_leu_zip PF10473.9 ETO06513.1 - 0.017 15.2 7.9 0.017 15.2 7.9 3.0 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 BLOC1_2 PF10046.9 ETO06513.1 - 0.029 14.7 17.6 0.077 13.3 3.6 4.2 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 ETO06513.1 - 0.056 13.5 26.6 0.027 14.6 10.4 3.0 3 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 ETO06513.1 - 0.14 11.5 18.1 0.046 13.0 1.6 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) Fez1 PF06818.15 ETO06513.1 - 0.22 12.0 21.9 0.86 10.0 8.7 3.2 3 1 0 3 3 3 0 Fez1 DUF4201 PF13870.6 ETO06513.1 - 2.5 7.8 26.6 0.41 10.4 7.9 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4201) YabA PF06156.13 ETO06513.1 - 2.9 8.6 21.8 1.7 9.3 3.8 3.3 3 1 0 3 3 3 0 Initiation control protein YabA GAS PF13851.6 ETO06513.1 - 4.5 6.6 32.2 0.85 8.9 5.7 3.7 3 1 0 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4407 PF14362.6 ETO06513.1 - 6.9 5.9 10.1 77 2.5 10.1 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.8 ETO06513.1 - 7.3 6.7 22.0 0.67 10.0 6.1 3.1 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding TMPIT PF07851.13 ETO06513.1 - 9.4 5.4 19.8 0.65 9.2 6.4 2.8 3 0 0 3 3 3 0 TMPIT-like protein AAT PF03417.16 ETO06515.1 - 2.8e-05 23.9 0.0 0.0036 17.0 0.0 2.1 1 1 0 1 1 1 1 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Nrap_D5 PF17406.2 ETO06515.1 - 0.31 10.8 2.3 16 5.2 0.0 2.2 2 0 0 2 2 2 0 Nrap protein PAP/OAS1-like domain 5 DUF789 PF05623.12 ETO06516.1 - 0.33 10.6 5.2 0.4 10.3 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF789) Presenilin PF01080.17 ETO06516.1 - 0.97 8.1 7.1 0.99 8.1 7.1 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO06516.1 - 4.8 7.2 5.7 5.1 7.1 5.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DivIC PF04977.15 ETO06518.1 - 0.15 11.9 2.7 3 7.7 0.8 2.3 2 0 0 2 2 2 0 Septum formation initiator DAGAT PF03982.13 ETO06520.1 - 1.1e-20 73.7 0.3 1.6e-20 73.2 0.3 1.2 1 0 0 1 1 1 1 Diacylglycerol acyltransferase Popeye PF04831.13 ETO06520.1 - 9.3 6.4 7.4 34 4.6 7.4 1.9 1 0 0 1 1 1 0 Popeye protein conserved region CpcD PF01383.21 ETO06521.1 - 0.14 12.4 0.0 1.3 9.4 0.1 2.2 2 0 0 2 2 2 0 CpcD/allophycocyanin linker domain pXO2-34 PF17362.2 ETO06522.1 - 0.098 12.5 0.6 0.48 10.3 0.3 2.1 2 0 0 2 2 2 0 Family of unknown function Arm PF00514.23 ETO06523.1 - 1.6e-06 27.9 2.1 0.02 14.9 0.0 2.9 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat IBB PF01749.20 ETO06523.1 - 3.7e-06 27.3 6.3 1.7e-05 25.2 6.3 2.0 1 1 0 1 1 1 1 Importin beta binding domain HEAT_EZ PF13513.6 ETO06523.1 - 0.06 13.9 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 HEAT-like repeat Nop25 PF09805.9 ETO06523.1 - 0.14 12.6 6.1 0.25 11.8 6.1 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) PA26 PF04636.13 ETO06524.1 - 0.042 12.8 1.3 0.078 11.9 1.3 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Macoilin PF09726.9 ETO06524.1 - 3.6 6.0 16.5 4.8 5.6 16.5 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO06524.1 - 3.7 6.2 5.8 5.3 5.7 5.8 1.2 1 0 0 1 1 1 0 Presenilin SOG2 PF10428.9 ETO06524.1 - 3.8 6.6 18.6 5.4 6.1 18.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein TP53IP5 PF15331.6 ETO06525.1 - 0.36 10.9 6.0 0.55 10.4 6.0 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 PKD_channel PF08016.12 ETO06527.1 - 6.6e-09 34.9 0.9 9e-09 34.5 0.9 1.1 1 0 0 1 1 1 1 Polycystin cation channel Pkinase PF00069.25 ETO06528.1 - 1.2e-30 106.8 0.0 2.3e-30 105.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06528.1 - 8.8e-13 48.1 0.0 1.6e-12 47.2 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ETO06528.1 - 0.0014 18.3 0.2 0.0031 17.1 0.1 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kdo PF06293.14 ETO06528.1 - 0.0088 15.4 0.0 0.015 14.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO06528.1 - 0.011 15.0 0.0 0.024 14.0 0.0 1.5 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO06528.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family 3-HAO PF06052.12 ETO06528.1 - 0.14 11.8 0.0 0.32 10.6 0.0 1.6 1 0 0 1 1 1 0 3-hydroxyanthranilic acid dioxygenase Telomerase_RBD PF12009.8 ETO06529.1 - 5e-11 42.8 1.3 9.2e-11 42.0 0.7 1.7 1 1 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain RVT_1 PF00078.27 ETO06529.1 - 0.048 13.2 2.8 0.19 11.2 0.0 2.4 2 1 1 3 3 3 0 Reverse transcriptase (RNA-dependent DNA polymerase) Flavi_capsid PF01003.19 ETO06530.1 - 0.65 9.8 7.5 1.8 8.4 0.1 2.6 3 0 0 3 3 3 0 Flavivirus capsid protein C Cob_adeno_trans PF01923.18 ETO06531.1 - 0.067 13.3 1.0 0.11 12.6 0.5 1.6 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Pox_G5 PF04599.12 ETO06531.1 - 0.22 10.5 8.9 0.34 9.9 8.9 1.3 1 0 0 1 1 1 0 Poxvirus G5 protein DUF4252 PF14060.6 ETO06531.1 - 5.8 6.8 10.5 18 5.2 8.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) WD40 PF00400.32 ETO06532.1 - 8.7e-29 99.2 21.7 1.9e-05 25.3 0.1 7.9 8 0 0 8 8 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06532.1 - 5.2e-08 33.1 0.5 0.046 14.0 0.0 4.1 3 1 2 5 5 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06532.1 - 3.2e-07 29.4 2.0 0.18 10.4 0.0 4.1 2 2 2 4 4 4 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO06532.1 - 0.00066 20.3 12.1 0.0043 17.7 12.1 2.4 1 1 0 1 1 1 1 TRAF-type zinc finger YabA PF06156.13 ETO06532.1 - 0.0082 16.8 22.3 0.041 14.5 6.0 3.4 2 1 1 3 3 3 2 Initiation control protein YabA bZIP_1 PF00170.21 ETO06532.1 - 0.046 13.8 13.6 0.51 10.5 1.4 3.2 2 2 1 3 3 3 0 bZIP transcription factor HALZ PF02183.18 ETO06532.1 - 0.048 13.9 7.3 2.6 8.4 3.3 2.8 2 0 0 2 2 2 0 Homeobox associated leucine zipper ZapB PF06005.12 ETO06532.1 - 0.14 12.6 17.7 0.14 12.7 5.7 2.6 1 1 1 2 2 2 0 Cell division protein ZapB DivIC PF04977.15 ETO06532.1 - 0.18 11.6 10.0 0.7 9.7 0.7 2.9 2 1 0 2 2 2 0 Septum formation initiator Peptidase_M17_N PF02789.17 ETO06532.1 - 0.22 11.4 0.4 0.48 10.3 0.4 1.5 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain NRBF2 PF08961.10 ETO06532.1 - 0.22 11.1 11.1 0.67 9.5 4.0 2.3 1 1 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator JIP_LZII PF16471.5 ETO06532.1 - 0.26 11.5 13.3 2.9 8.1 8.4 2.6 1 1 1 2 2 2 0 JNK-interacting protein leucine zipper II Rootletin PF15035.6 ETO06532.1 - 7.6 6.5 19.6 29 4.6 19.6 1.9 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion ALMT PF11744.8 ETO06534.1 - 0.17 10.6 1.4 0.28 10.0 1.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO06534.1 - 0.19 10.5 1.5 0.19 10.5 1.5 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO06534.1 - 0.48 9.2 3.7 0.66 8.7 3.7 1.2 1 1 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 G-alpha PF00503.20 ETO06535.1 - 0.00011 21.5 0.0 0.00011 21.5 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Slx4 PF09494.10 ETO06535.1 - 0.024 14.6 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Slx4 endonuclease TAF4 PF05236.14 ETO06536.1 - 0.011 15.5 7.7 0.016 15.0 7.7 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Tim54 PF11711.8 ETO06536.1 - 0.012 14.4 5.3 0.014 14.2 5.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Borrelia_P83 PF05262.11 ETO06536.1 - 0.017 13.7 8.8 0.018 13.5 8.8 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein RPN2_C PF18004.1 ETO06536.1 - 0.062 13.2 10.6 0.13 12.2 10.6 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 ETO06536.1 - 0.07 11.4 5.6 0.071 11.4 5.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4366 PF14283.6 ETO06536.1 - 0.073 13.1 7.4 0.14 12.2 7.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Pal1 PF08316.11 ETO06536.1 - 0.13 13.0 5.2 0.2 12.4 4.0 1.8 2 0 0 2 2 2 0 Pal1 cell morphology protein Zip PF02535.22 ETO06536.1 - 0.32 10.2 1.6 0.3 10.3 1.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_polI_A34 PF08208.11 ETO06536.1 - 1.3 9.1 13.7 2 8.5 13.7 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RRN3 PF05327.11 ETO06536.1 - 1.3 7.4 4.7 1.7 7.1 4.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NPR3 PF03666.13 ETO06536.1 - 1.5 7.5 8.0 1.9 7.2 8.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Spt20 PF12090.8 ETO06536.1 - 2.2 7.8 8.7 3.4 7.2 8.7 1.2 1 0 0 1 1 1 0 Spt20 family PRC2_HTH_1 PF18118.1 ETO06536.1 - 2.4 9.0 12.6 59 4.5 10.2 2.6 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Presenilin PF01080.17 ETO06536.1 - 2.6 6.7 10.3 3.7 6.2 10.3 1.2 1 0 0 1 1 1 0 Presenilin Rota_VP2 PF05087.12 ETO06536.1 - 3 5.9 0.0 3 5.9 0.0 2.0 2 0 0 2 2 1 0 Rotavirus VP2 protein RR_TM4-6 PF06459.12 ETO06536.1 - 3.3 7.5 15.8 5.5 6.7 15.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PAP_RNA-bind PF04926.15 ETO06536.1 - 4.3 6.9 8.5 3.7 7.2 6.4 1.8 2 1 0 2 2 2 0 Poly(A) polymerase predicted RNA binding domain Peptidase_S64 PF08192.11 ETO06536.1 - 5 5.5 9.5 6.5 5.1 9.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 K_channel_TID PF07941.11 ETO06536.1 - 5.2 7.6 11.5 5.9 7.4 3.0 2.6 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Hid1 PF12722.7 ETO06536.1 - 5.3 5.0 5.4 5.9 4.9 5.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sec62 PF03839.16 ETO06536.1 - 8.4 5.8 12.8 21 4.5 12.1 1.8 2 0 0 2 2 2 0 Translocation protein Sec62 SLC12 PF03522.15 ETO06536.1 - 8.4 5.3 9.0 12 4.8 9.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Vfa1 PF08432.10 ETO06536.1 - 8.9 6.6 16.8 7.3 6.9 14.5 1.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Serum_albumin PF00273.20 ETO06538.1 - 0.0034 17.2 0.0 0.0088 15.8 0.0 1.7 1 0 0 1 1 1 1 Serum albumin family DUF2183 PF09949.9 ETO06539.1 - 0.055 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2183) Orf78 PF06024.12 ETO06541.1 - 3.3e-05 24.1 6.9 4e-05 23.9 6.9 1.0 1 0 0 1 1 1 1 Orf78 (ac78) HCO3_cotransp PF00955.21 ETO06541.1 - 0.0013 17.7 1.3 0.0014 17.6 1.3 1.0 1 0 0 1 1 1 1 HCO3- transporter family Fig1 PF12351.8 ETO06541.1 - 0.011 15.7 0.3 0.013 15.5 0.3 1.0 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 ABC2_membrane_3 PF12698.7 ETO06541.1 - 0.017 14.2 6.4 0.02 14.0 6.4 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Ctr PF04145.15 ETO06541.1 - 0.049 14.2 0.2 0.053 14.1 0.2 1.0 1 0 0 1 1 1 0 Ctr copper transporter family GET2 PF08690.10 ETO06541.1 - 0.055 13.1 2.0 0.064 12.9 2.0 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 ETRAMP PF09716.10 ETO06541.1 - 3.2 7.9 10.3 6.2 7.0 10.3 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) NACHT PF05729.12 ETO06542.1 - 1.6e-07 31.4 0.0 2.7e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 NACHT domain SSP160 PF06933.11 ETO06544.1 - 0.0049 15.2 5.5 0.0069 14.7 5.5 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Pkinase PF00069.25 ETO06545.1 - 5.4e-41 140.7 0.1 9.8e-41 139.9 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06545.1 - 5.4e-21 75.0 0.0 2.5e-20 72.9 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase YrbL-PhoP_reg PF10707.9 ETO06545.1 - 0.023 14.2 0.0 0.045 13.3 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 ETO06545.1 - 0.03 13.9 0.9 0.12 11.9 0.1 2.3 2 1 1 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 Shisa PF13908.6 ETO06545.1 - 0.031 14.5 0.1 0.046 14.0 0.1 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Pkinase_fungal PF17667.1 ETO06545.1 - 0.083 11.6 0.8 0.12 11.1 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase APH PF01636.23 ETO06545.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ETO06545.1 - 0.1 12.0 0.0 0.21 10.9 0.0 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MTS PF05175.14 ETO06547.1 - 0.00011 21.8 0.0 0.00025 20.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase small domain ICMT PF04140.14 ETO06547.1 - 0.062 13.7 0.0 0.14 12.6 0.0 1.5 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Menin PF05053.13 ETO06548.1 - 0.54 8.6 6.4 0.58 8.5 6.4 1.1 1 0 0 1 1 1 0 Menin SWI-SNF_Ssr4 PF08549.10 ETO06548.1 - 0.62 8.6 8.1 0.82 8.2 8.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Pkinase PF00069.25 ETO06549.1 - 0.00075 18.9 0.0 0.0011 18.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06549.1 - 0.00083 18.7 0.0 0.0012 18.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase REJ PF02010.15 ETO06550.1 - 0.00053 18.9 7.0 0.00081 18.3 7.0 1.3 1 0 0 1 1 1 1 REJ domain fn3 PF00041.21 ETO06550.1 - 0.0049 17.2 1.7 0.65 10.4 0.4 3.1 2 1 0 2 2 2 2 Fibronectin type III domain Menin PF05053.13 ETO06553.1 - 0.89 7.8 12.3 1.2 7.4 12.3 1.3 1 0 0 1 1 1 0 Menin Troponin-I_N PF11636.8 ETO06554.1 - 0.072 13.0 1.4 0.19 11.7 1.4 1.6 1 0 0 1 1 1 0 Troponin I residues 1-32 zf-C3HC4 PF00097.25 ETO06554.1 - 2.7 7.9 16.2 8 6.4 16.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SR-25 PF10500.9 ETO06555.1 - 0.072 12.7 4.9 0.09 12.4 4.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Apis_Csd PF11671.8 ETO06555.1 - 0.14 12.2 18.0 0.32 11.0 18.0 1.5 1 0 0 1 1 1 0 Complementary sex determiner protein WD40 PF00400.32 ETO06556.1 - 3e-16 59.5 11.7 2.1e-06 28.4 0.9 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO06556.1 - 0.023 13.4 0.2 3.9 6.0 0.1 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 B56 PF01603.20 ETO06557.1 - 8.5e-09 34.9 1.1 0.00012 21.3 0.0 2.5 2 1 1 3 3 3 2 Protein phosphatase 2A regulatory B subunit (B56 family) DUF3956 PF13104.6 ETO06557.1 - 0.16 12.2 0.3 0.36 11.1 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3956) FlaC_arch PF05377.11 ETO06559.1 - 0.06 13.7 29.4 0.17 12.3 0.1 6.3 5 2 0 5 5 5 0 Flagella accessory protein C (FlaC) NAPRTase_N PF17767.1 ETO06559.1 - 0.55 10.6 7.7 0.14 12.5 1.5 2.9 3 0 0 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain EnY2 PF10163.9 ETO06560.1 - 0.24 11.8 6.1 0.26 11.7 4.7 1.8 1 1 0 1 1 1 0 Transcription factor e(y)2 CppA_N PF14506.6 ETO06560.1 - 0.42 10.7 4.0 0.18 11.9 1.6 1.6 2 0 0 2 2 2 0 CppA N-terminal Pkinase_Tyr PF07714.17 ETO06561.1 - 2e-40 138.7 0.0 3.7e-40 137.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO06561.1 - 1.8e-23 83.3 0.0 3.6e-23 82.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO06561.1 - 0.00046 19.1 0.0 0.00046 19.1 0.0 1.9 2 1 0 2 2 2 1 Fungal protein kinase APC_N_CC PF16689.5 ETO06561.1 - 0.077 13.1 0.1 0.23 11.5 0.1 1.8 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain Kdo PF06293.14 ETO06561.1 - 0.13 11.6 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DAP PF15228.6 ETO06561.1 - 9.1 7.5 8.2 21 6.4 0.0 3.2 2 1 1 3 3 3 0 Death-associated protein Pkinase PF00069.25 ETO06562.1 - 3.7e-26 92.1 3.5 3.6e-25 88.8 3.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06562.1 - 7.8e-11 41.7 0.3 1.4e-08 34.4 0.1 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Tis11B_N PF04553.12 ETO06562.1 - 0.061 13.9 0.2 0.11 13.1 0.2 1.4 1 0 0 1 1 1 0 Tis11B like protein, N terminus Dehydrin PF00257.19 ETO06563.1 - 0.019 15.5 0.0 0.1 13.2 0.0 2.0 1 1 0 1 1 1 0 Dehydrin UPF0254 PF06787.11 ETO06563.1 - 0.065 13.0 0.0 0.095 12.5 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) zf-C2H2_assoc2 PF16624.5 ETO06563.1 - 5.6 8.0 7.3 1.6 9.8 4.1 1.7 2 0 0 2 2 2 0 Unstructured region upstream of a zinc-finger WD40 PF00400.32 ETO06564.1 - 2.1e-30 104.3 29.5 4.5e-07 30.5 0.1 7.8 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06564.1 - 1.3e-08 35.0 0.5 0.035 14.4 0.0 4.6 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06564.1 - 4.2e-07 29.0 6.0 0.81 8.3 0.1 4.9 2 2 2 5 5 5 4 Nucleoporin Nup120/160 C5-epim_C PF06662.13 ETO06564.1 - 0.052 13.0 0.1 3.6 7.0 0.0 2.3 1 1 1 2 2 2 0 D-glucuronyl C5-epimerase C-terminus TPR_12 PF13424.6 ETO06566.1 - 1.3e-103 339.4 19.0 4.8e-18 65.2 0.1 7.3 2 2 5 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06566.1 - 1.6e-62 205.9 0.0 1.5e-07 31.1 0.0 11.1 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06566.1 - 1.9e-49 163.5 56.4 3.7e-07 29.7 1.1 11.4 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06566.1 - 1.3e-47 156.4 10.9 9.1e-06 25.4 0.1 10.0 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06566.1 - 1.1e-43 143.8 44.3 4e-06 26.5 0.7 11.3 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06566.1 - 4.2e-42 138.8 53.5 1e-06 28.5 1.3 10.6 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_11 PF13414.6 ETO06566.1 - 5.9e-19 67.5 35.6 5e-06 26.1 1.0 9.8 9 0 0 9 9 9 5 TPR repeat TPR_MalT PF17874.1 ETO06566.1 - 2.4e-16 60.0 0.0 1.2e-06 28.2 0.0 3.2 1 1 1 3 3 3 3 MalT-like TPR region TPR_14 PF13428.6 ETO06566.1 - 6.3e-16 57.7 0.0 1.2 10.1 0.0 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06566.1 - 6.3e-15 55.5 0.0 0.011 16.3 0.0 8.0 6 3 1 7 7 7 3 Tetratricopeptide repeat SNAP PF14938.6 ETO06566.1 - 2.2e-13 50.3 8.4 4.2e-05 23.1 0.3 4.6 1 1 2 4 4 4 4 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO06566.1 - 4e-13 48.7 13.1 0.12 12.8 0.4 10.3 8 4 2 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06566.1 - 4.1e-13 49.0 11.8 0.77 10.5 0.0 9.8 10 0 0 10 10 9 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO06566.1 - 2.7e-11 43.5 21.6 0.054 13.3 0.1 9.0 7 2 3 10 10 9 5 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO06566.1 - 5.9e-07 29.9 2.5 0.61 10.6 0.0 4.9 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO06566.1 - 3.7e-06 26.8 28.3 0.26 11.3 0.3 8.2 8 0 0 8 8 8 3 Tetratricopeptide repeat Sel1 PF08238.12 ETO06566.1 - 2.7e-05 24.7 10.2 6.5 7.6 0.0 7.3 7 0 0 7 7 7 0 Sel1 repeat MIT PF04212.18 ETO06566.1 - 3.5e-05 23.8 29.3 5.7 7.1 0.3 8.4 8 1 1 9 9 8 2 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO06566.1 - 0.00043 19.7 5.0 12 5.4 0.1 6.1 6 0 0 6 6 6 0 SHNi-TPR HTH_Bact PF18768.1 ETO06566.1 - 0.00085 18.9 13.6 13 5.5 0.1 7.3 7 0 0 7 7 6 0 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO06566.1 - 0.00094 19.2 11.1 2.6 8.1 0.1 6.1 4 4 1 5 5 5 2 Protein of unknown function (DUF627) DUF3856 PF12968.7 ETO06566.1 - 0.0016 18.5 10.3 12 6.0 0.1 6.0 1 1 5 6 6 6 0 Domain of Unknown Function (DUF3856) Mob_Pre PF01076.19 ETO06566.1 - 0.0025 17.7 19.6 0.21 11.4 1.6 5.5 2 2 4 6 6 6 3 Plasmid recombination enzyme DUF2977 PF11192.8 ETO06566.1 - 0.012 15.7 0.2 43 4.3 0.0 5.2 6 0 0 6 6 6 0 Protein of unknown function (DUF2977) SPO22 PF08631.10 ETO06566.1 - 0.015 14.8 13.3 0.36 10.3 0.9 4.9 2 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like KH_4 PF13083.6 ETO06566.1 - 0.017 15.0 0.1 0.15 12.0 0.0 2.6 2 0 0 2 2 2 0 KH domain UxuA PF03786.13 ETO06566.1 - 0.04 12.8 2.0 0.66 8.7 0.1 3.0 1 1 1 3 3 3 0 D-mannonate dehydratase (UxuA) DUF4058 PF13267.6 ETO06566.1 - 0.23 10.8 3.8 7.1 6.0 0.0 3.7 3 1 2 5 5 4 0 Protein of unknown function (DUF4058) PPR PF01535.20 ETO06566.1 - 0.24 11.7 25.0 11 6.5 0.3 8.4 10 0 0 10 10 9 0 PPR repeat eIF3m_C_helix PF18005.1 ETO06568.1 - 0.0067 16.1 0.9 0.02 14.6 0.9 1.9 1 0 0 1 1 1 1 eIF3 subunit M, C-terminal helix Exo_endo_phos_2 PF14529.6 ETO06568.1 - 0.032 14.1 5.6 0.06 13.2 3.0 2.6 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO06568.1 - 0.048 13.2 0.1 0.066 12.7 0.1 1.3 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family GP41 PF00517.17 ETO06568.1 - 3 7.7 8.9 0.33 10.8 3.8 2.0 2 0 0 2 2 2 0 Retroviral envelope protein WD40 PF00400.32 ETO06571.1 - 2.1e-47 158.1 22.0 4.4e-10 40.0 0.1 8.2 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06571.1 - 1.1e-15 57.6 1.7 8.6e-05 22.8 0.0 7.1 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06571.1 - 4.4e-09 36.1 6.4 0.0034 16.7 0.1 4.1 3 1 1 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO06571.1 - 9e-09 34.7 4.4 0.24 10.3 0.0 6.0 3 1 3 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO06571.1 - 2e-05 23.3 0.6 0.14 10.7 0.0 3.3 2 1 1 3 3 3 2 Cytochrome D1 heme domain Kelch_6 PF13964.6 ETO06571.1 - 7.1e-05 23.0 3.2 2.5 8.5 0.2 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO06571.1 - 0.00043 19.8 1.3 0.005 16.4 0.5 2.8 2 0 0 2 2 2 1 Kelch motif DUF5570 PF17731.1 ETO06571.1 - 0.0017 18.5 0.8 19 5.4 0.1 4.0 2 2 3 5 5 5 0 Family of unknown function (DUF5570) VID27 PF08553.10 ETO06571.1 - 0.011 14.9 0.1 0.49 9.4 0.0 2.6 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Kelch_4 PF13418.6 ETO06571.1 - 0.015 15.3 3.8 0.072 13.1 0.2 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain BBS2_Mid PF14783.6 ETO06571.1 - 0.058 13.4 2.7 3.4 7.7 0.1 4.5 3 2 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Kelch_5 PF13854.6 ETO06571.1 - 0.09 12.8 2.0 0.38 10.8 0.8 2.7 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO06571.1 - 0.32 11.3 1.6 0.85 10.0 0.1 2.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06571.1 - 3.1 7.9 6.9 6.7 6.9 1.0 4.2 4 1 0 4 4 4 0 Kelch motif Phage_holin_3_3 PF16083.5 ETO06572.1 - 0.15 12.2 6.4 2.4 8.3 0.8 2.5 2 0 0 2 2 2 0 LydA holin phage, holin superfamily III Chromate_transp PF02417.15 ETO06572.1 - 4.7 7.3 20.1 2.3 8.3 9.5 2.1 2 0 0 2 2 2 0 Chromate transporter APC_u14 PF16635.5 ETO06574.1 - 4.7 7.8 7.0 2.9 8.5 0.9 2.2 2 0 0 2 2 2 0 Unstructured region on APC between SAMP and APC_crr MMS19_N PF14500.6 ETO06575.1 - 5.7e-05 22.8 3.1 0.069 12.7 0.0 3.3 2 2 1 3 3 3 2 Dos2-interacting transcription regulator of RNA-Pol-II IPK PF03770.16 ETO06575.1 - 0.026 14.4 2.0 0.03 14.2 0.2 2.0 2 0 0 2 2 2 0 Inositol polyphosphate kinase KicB PF03882.14 ETO06575.1 - 0.089 13.0 2.5 32 4.8 0.0 3.9 2 2 1 3 3 3 0 MukF winged-helix domain DUF2670 PF10875.8 ETO06575.1 - 0.17 12.0 7.3 11 6.2 0.5 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF2670) SMC_N PF02463.19 ETO06575.1 - 1.4 8.3 3.5 0.61 9.5 0.6 1.9 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain Imm30 PF15565.6 ETO06575.1 - 9.7 6.3 14.0 3.1 7.9 4.2 3.9 3 2 1 4 4 4 0 Immunity protein 30 FH2 PF02181.23 ETO06576.1 - 4.9e-13 49.0 0.1 5.4e-13 48.8 0.1 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain FH2 PF02181.23 ETO06577.1 - 1.5e-38 132.9 20.7 1.9e-28 99.7 1.9 3.8 3 1 0 3 3 3 2 Formin Homology 2 Domain DUF2232 PF09991.9 ETO06577.1 - 0.11 11.6 1.8 0.14 11.3 0.3 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) CNDH2_N PF06278.11 ETO06577.1 - 0.24 11.6 0.1 0.24 11.6 0.1 4.0 4 0 0 4 4 4 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal GFO_IDH_MocA PF01408.22 ETO06578.1 - 1.9e-06 28.7 0.0 3.1e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold Put_DNA-bind_N PF06971.13 ETO06578.1 - 0.04 13.9 0.0 0.84 9.7 0.0 2.6 2 1 1 3 3 3 0 Putative DNA-binding protein N-terminus RCC1 PF00415.18 ETO06579.1 - 4.1e-23 81.7 12.4 8.2e-09 36.0 0.0 5.0 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO06579.1 - 1.5e-19 69.2 26.5 4.8e-09 35.8 5.6 3.9 4 1 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat TSP_1 PF00090.19 ETO06580.1 - 0.016 15.4 8.3 0.031 14.5 7.6 1.9 1 1 0 1 1 1 0 Thrombospondin type 1 domain HMMR_N PF15905.5 ETO06581.1 - 0.0011 18.6 23.6 0.0014 18.2 23.6 1.0 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal DUF948 PF06103.11 ETO06581.1 - 0.005 17.1 2.6 0.005 17.1 2.6 2.2 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) Taxilin PF09728.9 ETO06581.1 - 0.0079 15.4 30.1 0.01 15.1 30.1 1.1 1 0 0 1 1 1 1 Myosin-like coiled-coil protein DUF4407 PF14362.6 ETO06581.1 - 0.025 14.0 11.3 0.028 13.8 11.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ETO06581.1 - 0.032 13.1 22.8 0.035 13.0 22.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein ERM PF00769.19 ETO06581.1 - 0.04 13.7 20.2 0.055 13.3 20.2 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family PKcGMP_CC PF16808.5 ETO06581.1 - 0.1 12.5 0.1 0.1 12.5 0.1 3.8 4 1 0 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Tropomyosin_1 PF12718.7 ETO06581.1 - 0.11 12.6 25.8 0.16 12.1 7.8 2.3 1 1 1 2 2 2 0 Tropomyosin like ATG16 PF08614.11 ETO06581.1 - 0.15 12.2 20.8 0.75 10.0 20.8 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Prefoldin PF02996.17 ETO06581.1 - 0.16 11.9 24.8 2.1 8.3 4.1 3.1 3 0 0 3 3 3 0 Prefoldin subunit HiaBD2 PF15403.6 ETO06581.1 - 0.16 12.4 0.4 0.16 12.4 0.4 2.6 2 1 1 3 3 2 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) GAS PF13851.6 ETO06581.1 - 0.28 10.5 30.5 0.66 9.3 13.9 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4200 PF13863.6 ETO06581.1 - 0.7 10.3 30.9 6.7 7.1 30.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) FAM76 PF16046.5 ETO06581.1 - 0.74 9.1 21.5 1.3 8.3 21.5 1.4 1 1 0 1 1 1 0 FAM76 protein DUF641 PF04859.12 ETO06581.1 - 0.76 10.1 20.2 3.2 8.1 9.3 2.1 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) UPF0242 PF06785.11 ETO06581.1 - 0.8 9.8 26.6 1.1 9.3 26.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GrpE PF01025.19 ETO06581.1 - 1.2 8.8 23.7 0.71 9.5 9.4 2.2 1 1 1 2 2 2 0 GrpE Exonuc_VII_L PF02601.15 ETO06581.1 - 1.9 8.0 17.2 2.2 7.8 17.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETO06581.1 - 2.1 8.4 17.9 4.1 7.4 7.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 ETO06581.1 - 2.4 8.9 10.5 2.9 8.6 8.4 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF812 PF05667.11 ETO06581.1 - 2.5 6.9 26.1 2 7.2 8.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) DUF724 PF05266.14 ETO06581.1 - 3 7.6 23.4 0.92 9.3 15.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) BST2 PF16716.5 ETO06581.1 - 3.1 8.4 25.3 0.41 11.3 11.2 2.5 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Atg14 PF10186.9 ETO06581.1 - 4.3 6.3 20.0 7.2 5.6 20.0 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF5401 PF17380.2 ETO06581.1 - 4.5 5.2 18.9 5 5.1 18.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) YvrJ PF12841.7 ETO06581.1 - 4.6 6.9 5.5 6.1 6.5 0.8 3.1 3 0 0 3 3 3 0 YvrJ protein family LPP PF04728.13 ETO06581.1 - 4.8 7.7 15.7 29 5.1 2.7 3.7 2 2 0 2 2 2 0 Lipoprotein leucine-zipper HIP1_clath_bdg PF16515.5 ETO06581.1 - 5.5 7.7 25.8 9.1 7.0 18.4 2.4 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMPIT PF07851.13 ETO06581.1 - 5.8 6.1 22.2 1.1 8.5 14.8 2.0 1 1 1 2 2 2 0 TMPIT-like protein WDCP PF15390.6 ETO06581.1 - 6 5.1 17.7 6.7 5.0 17.7 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family SlyX PF04102.12 ETO06581.1 - 8.9 7.0 21.9 12 6.7 0.9 2.7 1 1 2 3 3 3 0 SlyX Jnk-SapK_ap_N PF09744.9 ETO06581.1 - 9.4 6.4 24.6 12 6.1 23.4 1.8 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 ETO06582.1 - 0.12 11.9 7.4 0.15 11.6 7.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Golgin_A5 PF09787.9 ETO06582.1 - 0.29 10.6 11.4 0.4 10.1 11.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 WRKY PF03106.15 ETO06583.1 - 0.024 14.8 4.9 0.74 10.1 0.0 2.6 2 0 0 2 2 2 0 WRKY DNA -binding domain GLTP PF08718.11 ETO06584.1 - 0.018 15.3 1.8 0.018 15.3 1.8 2.3 2 1 0 2 2 2 0 Glycolipid transfer protein (GLTP) Aa_trans PF01490.18 ETO06584.1 - 0.048 12.4 1.2 0.12 11.1 1.2 1.6 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein Peptidase_C14 PF00656.22 ETO06585.1 - 0.0011 19.0 0.9 0.0086 16.1 0.2 2.5 2 1 0 2 2 2 1 Caspase domain WD40 PF00400.32 ETO06586.1 - 0.0017 19.1 0.8 0.14 13.1 0.2 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06587.1 - 3.3e-05 24.1 0.2 0.38 11.1 0.1 4.2 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO06587.1 - 0.001 19.8 0.1 9.3 7.3 0.0 4.6 3 1 0 3 3 3 1 WD domain, G-beta repeat DUF4131 PF13567.6 ETO06588.1 - 1.3 8.7 9.9 0.51 10.0 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF2244 PF10003.9 ETO06589.1 - 0.029 14.0 0.1 0.053 13.2 0.1 1.4 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) DUF5423 PF17461.2 ETO06589.1 - 0.037 12.9 0.2 0.058 12.2 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5423) CAP_GLY PF01302.25 ETO06589.1 - 0.081 13.0 0.0 0.22 11.6 0.0 1.7 2 0 0 2 2 2 0 CAP-Gly domain Spore_coat_CotO PF14153.6 ETO06590.1 - 0.4 10.6 30.6 0.48 10.3 30.6 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Velvet PF11754.8 ETO06590.1 - 0.52 10.2 6.5 0.58 10.0 6.5 1.1 1 0 0 1 1 1 0 Velvet factor DUF5427 PF10310.9 ETO06590.1 - 1.6 7.6 28.2 1.8 7.4 28.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 ETO06590.1 - 2.7 7.8 35.0 3.6 7.3 35.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SLC12 PF03522.15 ETO06590.1 - 3.6 6.5 27.1 3.9 6.4 27.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 ETO06590.1 - 4.4 5.9 20.3 4.5 5.9 20.3 1.0 1 0 0 1 1 1 0 Raftlin MAJIN PF15077.6 ETO06590.1 - 5.8 6.6 18.1 7 6.4 18.1 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF3807 PF12720.7 ETO06590.1 - 6.3 7.0 35.1 7.3 6.8 35.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Borrelia_P83 PF05262.11 ETO06590.1 - 9 4.7 41.7 11 4.4 41.7 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein SPOUT_MTase PF02590.17 ETO06591.1 - 5.8 6.9 8.9 0.37 10.8 0.7 2.3 2 1 0 2 2 2 0 Predicted SPOUT methyltransferase Tox-REase-5 PF15648.6 ETO06592.1 - 0.51 10.9 10.1 0.89 10.1 1.6 2.7 1 1 1 2 2 2 0 Restriction endonuclease fold toxin 5 MinC_N PF05209.13 ETO06594.1 - 0.015 15.2 0.0 0.047 13.7 0.0 1.8 1 0 0 1 1 1 0 Septum formation inhibitor MinC, N-terminal domain AAA PF00004.29 ETO06596.1 - 4.1e-12 46.7 0.0 1.8e-06 28.4 0.0 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO06596.1 - 5.1e-10 39.1 0.1 4.3e-06 26.4 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO06596.1 - 3.4e-08 33.6 0.5 0.00026 21.0 0.0 4.3 4 1 0 4 4 4 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO06596.1 - 3.2e-07 30.7 0.0 0.0049 17.1 0.0 3.3 3 0 0 3 3 3 2 AAA domain AAA_14 PF13173.6 ETO06596.1 - 6.8e-07 29.4 0.0 0.02 14.9 0.0 3.0 2 0 0 2 2 2 2 AAA domain AAA_8 PF12780.7 ETO06596.1 - 7e-06 25.6 7.0 2.4e-05 23.8 0.1 3.5 4 1 1 5 5 5 1 P-loop containing dynein motor region D4 ABC_tran PF00005.27 ETO06596.1 - 2.5e-05 24.8 0.2 0.00045 20.8 0.0 2.8 3 0 0 3 3 2 1 ABC transporter AAA_16 PF13191.6 ETO06596.1 - 0.00011 22.6 0.0 0.0045 17.4 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO06596.1 - 0.00025 21.0 0.0 0.00065 19.6 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase Viral_helicase1 PF01443.18 ETO06596.1 - 0.0009 19.0 0.2 0.14 11.9 0.0 2.4 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_2 PF07724.14 ETO06596.1 - 0.0011 19.1 0.0 0.036 14.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ETO06596.1 - 0.0047 16.1 0.3 0.016 14.4 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TsaE PF02367.17 ETO06596.1 - 0.0085 16.1 0.0 0.15 12.0 0.0 2.6 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 ETO06596.1 - 0.009 16.0 0.6 0.36 10.7 0.0 2.9 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ETO06596.1 - 0.012 15.3 0.2 2 8.1 0.0 3.5 4 0 0 4 4 3 0 IstB-like ATP binding protein PduV-EutP PF10662.9 ETO06596.1 - 0.014 15.2 0.1 0.063 13.0 0.0 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ETO06596.1 - 0.019 14.9 0.1 0.48 10.3 0.1 2.7 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 ETO06596.1 - 0.024 14.3 0.1 0.68 9.6 0.0 3.0 4 0 0 4 4 2 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 ETO06596.1 - 0.04 13.3 0.4 4.5 6.6 0.0 3.0 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI MCM PF00493.23 ETO06596.1 - 0.051 12.7 0.5 1.2 8.2 0.0 2.7 3 0 0 3 3 3 0 MCM P-loop domain RNA_helicase PF00910.22 ETO06596.1 - 0.058 13.8 0.1 2.1 8.8 0.0 3.0 2 0 0 2 2 2 0 RNA helicase Sigma54_activ_2 PF14532.6 ETO06596.1 - 0.1 12.7 0.0 0.61 10.2 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_30 PF13604.6 ETO06596.1 - 0.22 11.2 0.1 32 4.2 0.0 2.8 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO06596.1 - 0.26 11.8 1.3 6.3 7.4 0.0 3.5 4 0 0 4 4 3 0 AAA domain AAA_19 PF13245.6 ETO06596.1 - 4.7 7.5 6.4 4.6 7.6 0.1 3.4 3 2 0 3 3 2 0 AAA domain DUF677 PF05055.12 ETO06597.1 - 0.0045 15.9 1.7 0.0063 15.4 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF677) SseC PF04888.12 ETO06597.1 - 0.16 11.6 8.3 0.19 11.3 8.3 1.4 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Tweety PF04906.13 ETO06597.1 - 0.8 8.3 4.5 0.13 10.9 0.7 1.5 2 0 0 2 2 2 0 Tweety SP_C-Propep PF08999.10 ETO06597.1 - 1.4 8.7 9.4 0.23 11.3 4.8 1.8 2 0 0 2 2 2 0 Surfactant protein C, N terminal propeptide DUF3357 PF11837.8 ETO06597.1 - 2 8.9 5.6 1.8 9.1 3.9 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3357) DUF2749 PF10907.8 ETO06597.1 - 8.2 6.7 8.1 0.93 9.7 2.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) DUF2448 PF10476.9 ETO06598.1 - 0.11 12.3 0.6 0.16 11.8 0.0 1.5 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) Nucleoporin_N PF08801.11 ETO06599.1 - 0.0023 16.8 0.1 0.005 15.6 0.0 1.5 1 1 1 2 2 2 1 Nup133 N terminal like ANAPC4_WD40 PF12894.7 ETO06599.1 - 0.04 14.2 0.0 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Spot_14 PF07084.12 ETO06599.1 - 0.041 14.0 0.2 0.041 14.0 0.2 1.6 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 WD40 PF00400.32 ETO06600.1 - 4.9e-23 81.0 11.1 0.00059 20.6 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06600.1 - 9.1e-07 29.1 0.2 0.13 12.5 0.0 4.3 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Utp12 PF04003.12 ETO06600.1 - 0.00039 20.7 0.0 0.00072 19.8 0.0 1.4 1 0 0 1 1 1 1 Dip2/Utp12 Family WD40_like PF17005.5 ETO06600.1 - 0.00057 19.3 0.4 0.02 14.2 0.1 2.9 3 1 1 4 4 4 1 WD40-like domain TPR_12 PF13424.6 ETO06600.1 - 0.026 14.8 0.0 0.048 14.0 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Ge1_WD40 PF16529.5 ETO06600.1 - 0.061 12.3 0.7 9.7 5.0 0.1 3.6 4 1 0 4 4 4 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF1179 PF06678.11 ETO06601.1 - 2.6 8.1 5.2 2.2 8.3 3.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) Med14 PF08638.11 ETO06603.1 - 0.0052 16.2 2.1 0.0095 15.4 0.5 2.0 2 0 0 2 2 2 1 Mediator complex subunit MED14 RESP18 PF14948.6 ETO06603.1 - 0.25 11.7 2.0 0.51 10.7 1.1 2.0 1 1 1 2 2 2 0 RESP18 domain ThiD2 PF17792.1 ETO06603.1 - 0.3 11.6 5.6 0.4 11.2 3.6 2.1 1 1 1 2 2 2 0 ThiD2 family AAA_23 PF13476.6 ETO06603.1 - 0.46 10.9 5.7 0.74 10.3 5.7 1.3 1 0 0 1 1 1 0 AAA domain XK-related PF09815.9 ETO06604.1 - 4.9e-14 52.1 2.7 4.9e-14 52.1 2.7 2.6 2 1 0 2 2 2 1 XK-related protein Herpes_LMP1 PF05297.11 ETO06605.1 - 9.9 5.2 9.7 0.44 9.7 2.1 2.0 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) Asn_synthase PF00733.21 ETO06606.1 - 1.8e-30 106.8 0.1 2.3e-30 106.5 0.1 1.0 1 0 0 1 1 1 1 Asparagine synthase WD40 PF00400.32 ETO06607.1 - 5.6e-06 27.0 3.0 0.055 14.4 0.2 3.8 2 1 1 3 3 3 2 WD domain, G-beta repeat CD20 PF04103.15 ETO06607.1 - 0.023 14.8 0.1 0.036 14.2 0.1 1.3 1 0 0 1 1 1 0 CD20-like family Guanylate_cyc PF00211.20 ETO06608.1 - 7.5e-25 87.6 0.0 9.5e-25 87.3 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain CpcD PF01383.21 ETO06609.1 - 0.1 12.9 0.1 0.2 12.0 0.1 1.5 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain SSL_OB PF09199.10 ETO06609.1 - 0.31 11.4 2.8 11 6.5 0.1 2.8 3 0 0 3 3 3 0 Staphylococcal superantigen-like OB-fold domain Ndc80_HEC PF03801.13 ETO06610.1 - 0.094 12.3 2.7 0.15 11.7 2.7 1.4 1 1 0 1 1 1 0 HEC/Ndc80p family NACHT PF05729.12 ETO06611.1 - 3.3e-07 30.4 0.0 4.5e-07 29.9 0.0 1.2 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO06611.1 - 0.00027 20.2 0.1 0.00041 19.6 0.0 1.5 1 1 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.9 ETO06611.1 - 0.0031 16.8 1.0 0.0051 16.1 0.0 1.8 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) RNA_helicase PF00910.22 ETO06611.1 - 0.0076 16.6 0.3 0.36 11.2 0.0 2.4 2 1 0 2 2 2 1 RNA helicase AAA_7 PF12775.7 ETO06611.1 - 0.0088 15.6 0.0 0.013 15.0 0.0 1.2 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_30 PF13604.6 ETO06611.1 - 0.015 15.0 0.2 0.11 12.2 0.0 1.9 1 1 1 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETO06611.1 - 0.016 14.9 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_22 PF13401.6 ETO06611.1 - 0.032 14.5 0.0 0.052 13.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO06611.1 - 0.034 14.5 0.0 0.045 14.1 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_25 PF13481.6 ETO06611.1 - 0.067 12.8 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain Herpes_Helicase PF02689.14 ETO06611.1 - 0.081 10.8 0.0 0.095 10.6 0.0 1.1 1 0 0 1 1 1 0 Helicase Hen1_Lam_C PF18441.1 ETO06611.1 - 0.085 12.7 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 Hen1 La-motif C-terminal domain ANAPC4_WD40 PF12894.7 ETO06612.1 - 1.3e-11 44.7 0.8 0.0012 19.1 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO06612.1 - 2.3e-11 44.1 8.3 0.00092 20.0 0.1 4.9 5 1 0 5 5 5 4 WD domain, G-beta repeat DUF851 PF05867.11 ETO06612.1 - 0.13 11.7 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF851) PilJ PF13675.6 ETO06613.1 - 0.065 13.3 0.6 0.12 12.4 0.6 1.4 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term Jnk-SapK_ap_N PF09744.9 ETO06613.1 - 0.28 11.4 13.6 0.58 10.4 13.6 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 ETO06613.1 - 0.56 10.3 25.0 1.2 9.3 25.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 ETO06613.1 - 1 8.8 11.3 1.5 8.4 11.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ETO06613.1 - 1.6 8.0 6.0 2.2 7.5 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YtxH PF12732.7 ETO06613.1 - 2.2 8.9 4.1 4.6 7.9 3.5 1.8 1 1 1 2 2 2 0 YtxH-like protein PhoU PF01895.19 ETO06613.1 - 2.5 8.6 6.2 0.95 10.0 0.9 2.3 1 1 1 2 2 2 0 PhoU domain Mt_ATP-synt_D PF05873.12 ETO06613.1 - 2.7 7.8 19.4 7 6.5 12.3 2.2 2 0 0 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) DUF2344 PF10105.9 ETO06613.1 - 4.5 7.1 8.5 7 6.5 8.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) RL10P_insert PF17777.1 ETO06614.1 - 1.7e-06 27.9 0.0 3.1e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P BUD22 PF09073.10 ETO06614.1 - 1.1 8.5 18.0 1.5 8.1 18.0 1.1 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 ETO06614.1 - 9.7 4.1 20.3 15 3.5 20.3 1.3 1 0 0 1 1 1 0 DNA polymerase phi G-alpha PF00503.20 ETO06615.1 - 4.1e-101 338.7 9.4 5.9e-101 338.2 9.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO06615.1 - 5.7e-10 38.9 2.4 2.3e-06 27.2 0.3 3.2 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO06615.1 - 0.0023 18.1 5.2 0.2 11.8 0.0 3.0 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ETO06615.1 - 0.0038 16.6 0.5 0.047 13.0 0.0 2.1 2 0 0 2 2 2 1 FtsK/SpoIIIE family TniB PF05621.11 ETO06615.1 - 0.0092 15.4 0.5 0.017 14.5 0.5 1.4 1 0 0 1 1 1 1 Bacterial TniB protein AAA_29 PF13555.6 ETO06615.1 - 0.023 14.4 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ETO06615.1 - 0.047 13.8 0.2 8.8 6.5 0.0 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase CAF1A PF12253.8 ETO06615.1 - 0.12 12.6 0.2 18 5.6 0.0 2.7 3 0 0 3 3 3 0 Chromatin assembly factor 1 subunit A ABC_tran PF00005.27 ETO06615.1 - 1.4 9.4 5.4 0.77 10.3 0.6 2.7 2 1 1 3 3 3 0 ABC transporter DivIC PF04977.15 ETO06615.1 - 4 7.3 14.7 2.5 7.9 1.0 2.6 2 0 0 2 2 2 0 Septum formation initiator Ion_trans PF00520.31 ETO06617.1 - 5.1e-13 48.8 28.2 1.6e-12 47.2 28.2 1.8 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ETO06617.1 - 1.3e-07 31.5 7.5 1.3e-07 31.5 7.5 2.7 2 1 0 2 2 2 1 Ion channel Lig_chan PF00060.26 ETO06617.1 - 9.7 6.0 6.4 1.1 9.1 1.4 2.2 2 1 0 2 2 2 0 Ligand-gated ion channel Acyltransferase PF01553.21 ETO06618.1 - 0.0062 16.2 0.1 0.019 14.6 0.1 1.8 1 0 0 1 1 1 1 Acyltransferase EF-hand_1 PF00036.32 ETO06618.1 - 0.015 14.8 4.2 0.7 9.6 1.2 2.8 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 ETO06618.1 - 0.028 14.4 3.3 0.5 10.4 1.5 2.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_5 PF13202.6 ETO06618.1 - 0.047 13.2 3.3 0.074 12.6 0.7 2.3 2 0 0 2 2 2 0 EF hand EF-hand_8 PF13833.6 ETO06618.1 - 0.12 12.2 2.6 2.2 8.2 0.6 2.5 2 0 0 2 2 2 0 EF-hand domain pair WD40 PF00400.32 ETO06619.1 - 1.5e-41 139.5 32.0 2.4e-08 34.5 0.6 8.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06619.1 - 1.8e-10 41.0 3.2 0.11 12.9 0.0 6.5 6 1 0 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06619.1 - 3e-09 36.1 4.1 0.02 13.5 0.0 5.1 2 2 3 5 5 5 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO06619.1 - 3e-05 24.6 2.3 0.00016 22.3 2.3 2.4 1 0 0 1 1 1 1 TRAF-type zinc finger ABC_tran_CTD PF16326.5 ETO06619.1 - 3.9 7.8 14.1 0.37 11.1 1.0 2.6 2 1 0 2 2 2 0 ABC transporter C-terminal domain APG6_N PF17675.1 ETO06619.1 - 7 7.2 35.1 1 9.9 21.8 3.7 2 1 1 3 3 3 0 Apg6 coiled-coil region HIRAN PF08797.11 ETO06620.1 - 4.2e-06 26.6 0.0 7.2e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 HIRAN domain Filament PF00038.21 ETO06621.1 - 0.00061 19.5 22.4 0.00061 19.5 22.4 2.4 1 1 2 3 3 3 2 Intermediate filament protein FAM76 PF16046.5 ETO06621.1 - 0.0037 16.7 12.6 0.0037 16.7 12.6 2.5 1 1 1 2 2 2 1 FAM76 protein PilJ PF13675.6 ETO06621.1 - 0.56 10.3 9.6 0.64 10.1 7.5 2.1 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Spc7 PF08317.11 ETO06621.1 - 5.4 5.8 43.3 3.6 6.4 2.8 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein AAA_33 PF13671.6 ETO06622.1 - 4.4e-10 39.9 0.0 7.1e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO06622.1 - 7.5e-05 23.3 0.1 0.00014 22.4 0.1 1.8 1 1 0 1 1 1 1 AAA domain KTI12 PF08433.10 ETO06622.1 - 0.00062 19.3 1.2 0.0013 18.2 1.2 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 cobW PF02492.19 ETO06622.1 - 0.0021 17.7 0.3 0.022 14.4 0.0 2.1 1 1 1 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain 6PF2K PF01591.18 ETO06622.1 - 0.003 16.9 0.2 0.0071 15.7 0.0 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase AAA_16 PF13191.6 ETO06622.1 - 0.0041 17.5 0.0 0.0056 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 ETO06622.1 - 0.0044 16.9 0.0 0.013 15.5 0.0 1.7 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 ETO06622.1 - 0.0068 15.6 0.0 0.011 15.0 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA PF00004.29 ETO06622.1 - 0.0076 16.7 0.0 0.015 15.8 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO06622.1 - 0.012 15.8 0.1 0.031 14.6 0.1 1.7 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO06622.1 - 0.015 15.8 0.0 0.032 14.8 0.0 1.6 1 1 0 1 1 1 0 ABC transporter dNK PF01712.19 ETO06622.1 - 0.019 14.8 0.0 0.038 13.8 0.0 1.5 1 1 0 1 1 1 0 Deoxynucleoside kinase AAA_24 PF13479.6 ETO06622.1 - 0.024 14.4 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ETO06622.1 - 0.026 13.8 0.0 0.55 9.5 0.0 2.2 2 0 0 2 2 2 0 Zeta toxin RNA_helicase PF00910.22 ETO06622.1 - 0.032 14.6 0.0 0.06 13.8 0.0 1.7 1 1 0 1 1 1 0 RNA helicase Viral_helicase1 PF01443.18 ETO06622.1 - 0.04 13.6 0.1 0.086 12.6 0.0 1.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ETO06622.1 - 0.041 13.1 0.0 0.076 12.2 0.0 1.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 ETO06622.1 - 0.044 14.2 0.0 0.12 12.8 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO06622.1 - 0.055 13.7 0.1 0.086 13.1 0.1 1.5 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETO06622.1 - 0.056 13.5 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_30 PF13604.6 ETO06622.1 - 0.059 13.1 0.0 0.1 12.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO06622.1 - 0.063 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) APS_kinase PF01583.20 ETO06622.1 - 0.092 12.6 0.0 0.59 10.0 0.0 2.0 2 0 0 2 2 2 0 Adenylylsulphate kinase TsaE PF02367.17 ETO06622.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_14 PF13173.6 ETO06622.1 - 0.16 12.0 0.8 0.3 11.1 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETO06622.1 - 0.21 11.2 0.0 0.55 9.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain SLC12 PF03522.15 ETO06623.1 - 1e-18 67.6 19.0 2.6e-10 39.9 0.0 3.1 1 1 1 3 3 3 2 Solute carrier family 12 SLC12 PF03522.15 ETO06624.1 - 3.1e-17 62.7 11.0 4.9e-16 58.8 11.0 1.9 1 1 0 1 1 1 1 Solute carrier family 12 SUIM_assoc PF16619.5 ETO06624.1 - 0.0023 18.0 8.2 0.0068 16.4 7.8 1.9 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Comm PF15957.5 ETO06624.1 - 0.019 15.3 1.3 0.031 14.6 1.3 1.5 1 1 0 1 1 1 0 Commissureless IL23 PF16649.5 ETO06624.1 - 0.037 14.1 0.2 0.037 14.1 0.2 2.0 1 1 1 2 2 2 0 Interleukin 23 subunit alpha Ctr PF04145.15 ETO06624.1 - 0.071 13.7 0.0 0.1 13.2 0.0 1.3 1 0 0 1 1 1 0 Ctr copper transporter family Consortin_C PF15281.6 ETO06624.1 - 0.096 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Consortin C-terminus Androgen_recep PF02166.16 ETO06624.1 - 1.2 8.0 11.7 1.3 7.8 11.7 1.1 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 ETO06624.1 - 1.6 8.3 18.9 2.2 7.8 18.9 1.2 1 0 0 1 1 1 0 Spt20 family DUF4660 PF15559.6 ETO06624.1 - 2.3 8.6 7.9 1.5 9.2 5.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4660) DUF2967 PF11179.8 ETO06624.1 - 4.4 5.3 8.3 5.4 5.0 8.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) TFIIA PF03153.13 ETO06624.1 - 8.9 6.2 17.6 11 5.9 17.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pkinase_Tyr PF07714.17 ETO06626.1 - 0.0034 16.7 0.0 0.0051 16.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO06626.1 - 0.044 13.1 0.0 0.066 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain UBA_4 PF14555.6 ETO06627.1 - 2.4e-07 30.4 0.1 4.1e-07 29.7 0.1 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ETO06627.1 - 0.024 14.2 0.1 0.16 11.6 0.0 2.2 2 0 0 2 2 2 0 TAP C-terminal domain DUF1488 PF07369.11 ETO06627.1 - 0.12 12.4 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) DTHCT PF08070.11 ETO06628.1 - 0.8 10.5 7.0 1.1 10.1 6.6 1.3 1 1 0 1 1 1 0 DTHCT (NUC029) region SurA_N_2 PF13623.6 ETO06629.1 - 0.022 14.6 0.8 0.022 14.6 0.8 2.6 3 0 0 3 3 3 0 SurA N-terminal domain SurA_N_3 PF13624.6 ETO06629.1 - 0.029 14.2 1.1 0.079 12.8 1.1 1.8 1 0 0 1 1 1 0 SurA N-terminal domain DUF507 PF04368.13 ETO06629.1 - 1.3 8.9 9.8 0.043 13.8 2.9 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF507) G-alpha PF00503.20 ETO06631.1 - 1.2e-25 90.4 0.4 1.5e-25 90.2 0.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit FtsK_SpoIIIE PF01580.18 ETO06631.1 - 0.00019 20.8 0.0 0.00029 20.3 0.0 1.3 1 1 0 1 1 1 1 FtsK/SpoIIIE family TniB PF05621.11 ETO06631.1 - 0.017 14.6 0.1 0.025 14.0 0.1 1.2 1 0 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 ETO06631.1 - 0.052 13.0 0.1 0.08 12.4 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO06631.1 - 0.056 13.5 0.2 0.081 13.0 0.2 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ETO06631.1 - 0.066 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 ETO06631.1 - 0.083 13.4 0.0 0.12 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ETO06631.1 - 0.12 12.6 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase 2OG-FeII_Oxy_3 PF13640.6 ETO06634.1 - 0.13 13.1 0.0 0.22 12.4 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Pkinase PF00069.25 ETO06635.1 - 0.00025 20.5 0.0 0.00057 19.3 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Fascin PF06268.13 ETO06637.1 - 0.043 14.1 0.1 0.063 13.5 0.1 1.5 1 1 0 1 1 1 0 Fascin domain CAP_GLY PF01302.25 ETO06639.1 - 2.2e-05 24.4 1.3 0.29 11.2 0.2 3.2 3 1 0 3 3 3 2 CAP-Gly domain Helicase_C PF00271.31 ETO06641.1 - 6.7e-14 52.2 0.1 1.7e-13 50.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ETO06641.1 - 0.016 13.9 0.1 0.026 13.2 0.1 1.3 1 0 0 1 1 1 0 SNF2 family N-terminal domain ERCC3_RAD25_C PF16203.5 ETO06641.1 - 0.036 13.3 0.0 0.085 12.1 0.0 1.6 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase DUF551 PF04448.12 ETO06641.1 - 0.11 13.4 0.4 0.4 11.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF551) TFIIB PF00382.19 ETO06642.1 - 0.15 12.1 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Transcription factor TFIIB repeat Pyr_redox_2 PF07992.14 ETO06644.1 - 1.2e-25 90.3 0.0 3e-25 89.1 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO06644.1 - 2.9e-17 63.0 0.1 5.8e-17 62.0 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO06644.1 - 4.3e-09 36.0 0.0 6.4e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ETO06644.1 - 0.08 13.4 0.0 0.1 13.0 0.0 1.4 1 0 0 1 1 1 0 Putative NAD(P)-binding Cyt-b5 PF00173.28 ETO06645.1 - 3.6e-22 78.3 0.0 5.3e-22 77.7 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Csc2 PF18320.1 ETO06646.1 - 0.011 14.7 1.9 0.017 14.0 0.2 2.0 2 1 1 3 3 3 0 Csc2 Crispr CCDC117 PF15810.5 ETO06646.1 - 0.044 14.1 0.0 0.08 13.3 0.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 Phage_T7_Capsid PF05396.11 ETO06646.1 - 0.052 13.9 0.1 0.34 11.3 0.0 2.2 2 1 0 2 2 2 0 Phage T7 capsid assembly protein DUF1394 PF07159.12 ETO06647.1 - 3.7e-07 29.7 0.0 7.2e-07 28.8 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) DUF4657 PF15552.6 ETO06648.1 - 0.58 9.7 7.9 0.044 13.3 2.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4657) Myco_arth_vir_N PF09610.10 ETO06649.1 - 0.53 10.4 4.2 1.7 8.8 4.2 1.8 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) CDC45 PF02724.14 ETO06650.1 - 3 6.0 11.1 3.5 5.8 11.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SecA_DEAD PF07517.14 ETO06651.1 - 6e-08 32.3 0.0 1.3e-07 31.2 0.0 1.5 1 0 0 1 1 1 1 SecA DEAD-like domain DUF1330 PF07045.11 ETO06651.1 - 0.064 13.6 0.4 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) HECT PF00632.25 ETO06653.1 - 4.8e-34 118.3 0.4 5.9e-34 117.9 0.4 1.1 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) MMU163 PF17119.5 ETO06654.1 - 0.031 13.5 0.4 0.032 13.4 0.4 1.0 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis VID27_N PF17748.1 ETO06655.1 - 0.073 12.9 0.0 0.084 12.7 0.0 1.2 1 0 0 1 1 1 0 VID27 N-terminal region DotA PF11388.8 ETO06656.1 - 0.088 13.0 0.5 0.14 12.3 0.5 1.3 1 0 0 1 1 1 0 Phagosome trafficking protein DotA Kelch_5 PF13854.6 ETO06658.1 - 1.1e-05 25.2 0.5 0.00067 19.6 0.1 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO06658.1 - 0.0014 18.8 0.6 0.029 14.7 0.2 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO06658.1 - 0.0023 17.5 0.0 0.0047 16.5 0.0 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 ETO06658.1 - 0.011 16.0 0.1 0.045 14.0 0.0 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06658.1 - 0.077 13.0 0.1 0.32 11.0 0.1 2.1 1 0 0 1 1 1 0 Kelch motif C2 PF00168.30 ETO06659.1 - 1.3e-19 70.3 0.2 3.2e-19 69.1 0.2 1.5 1 0 0 1 1 1 1 C2 domain Shisa PF13908.6 ETO06659.1 - 0.1 12.8 1.2 0.16 12.2 1.2 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Ras PF00071.22 ETO06661.1 - 3.2e-59 199.2 1.0 4.2e-59 198.8 1.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO06661.1 - 4e-32 111.0 0.1 7.4e-32 110.1 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO06661.1 - 1.7e-14 53.6 0.3 2.2e-14 53.3 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO06661.1 - 0.00014 21.5 0.1 0.00018 21.1 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF3533 PF12051.8 ETO06661.1 - 0.0039 16.2 0.3 0.0041 16.1 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3533) MMR_HSR1 PF01926.23 ETO06661.1 - 0.016 15.3 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase SRPRB PF09439.10 ETO06661.1 - 0.024 14.1 0.1 0.03 13.8 0.1 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETO06661.1 - 0.031 14.2 0.3 0.63 9.9 0.2 2.3 1 1 1 2 2 2 0 RsgA GTPase PRA1 PF03208.19 ETO06663.1 - 0.057 13.1 0.1 0.057 13.1 0.1 2.2 2 0 0 2 2 2 0 PRA1 family protein DUF2116 PF09889.9 ETO06663.1 - 0.23 11.5 1.0 26 4.9 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF3580 PF12117.8 ETO06664.1 - 0.017 15.3 0.1 0.022 15.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3580) XPG_I PF00867.18 ETO06666.1 - 4.2e-05 23.8 0.0 0.00011 22.5 0.0 1.7 1 0 0 1 1 1 1 XPG I-region T2SSM_b PF10741.9 ETO06666.1 - 0.22 11.3 0.0 0.49 10.2 0.0 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M subtype b Kelch_6 PF13964.6 ETO06667.1 - 8.1e-07 29.1 4.6 0.014 15.6 0.2 4.5 4 1 1 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO06667.1 - 1.5e-05 24.9 0.3 0.041 13.9 0.0 3.0 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO06667.1 - 1.7e-05 24.3 4.5 0.00015 21.3 0.3 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO06667.1 - 0.018 15.0 2.2 0.99 9.5 0.1 4.0 6 0 0 6 6 6 0 Kelch motif Kelch_3 PF13415.6 ETO06667.1 - 0.028 14.7 0.1 0.35 11.2 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO06667.1 - 0.17 11.9 5.0 3.1 7.9 0.1 4.4 5 1 0 5 5 5 0 Kelch motif MFS_1 PF07690.16 ETO06669.1 - 8.6e-05 21.6 2.7 0.00012 21.2 2.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Tmemb_170 PF10190.9 ETO06669.1 - 3 8.2 11.0 3.2 8.2 2.5 2.5 1 1 1 2 2 2 0 Putative transmembrane protein 170 DUF962 PF06127.11 ETO06670.1 - 4.9e-23 81.0 0.7 1.9e-22 79.2 0.7 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF962) ECH_2 PF16113.5 ETO06671.1 - 6.3e-68 229.7 0.0 1e-67 229.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ETO06671.1 - 5.2e-17 62.0 0.0 9.1e-17 61.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Nod1 PF17114.5 ETO06671.1 - 1.5 8.9 10.0 0.65 10.2 5.3 2.5 1 1 0 2 2 2 0 Gef2-related medial cortical node protein Nod1 WXG100 PF06013.12 ETO06673.1 - 0.00016 21.9 2.2 0.00039 20.6 2.2 1.8 1 1 0 1 1 1 1 Proteins of 100 residues with WXG Peptidase_C2 PF00648.21 ETO06674.1 - 1.1e-06 27.9 0.0 1.8e-06 27.2 0.0 1.3 1 0 0 1 1 1 1 Calpain family cysteine protease AAA_6 PF12774.7 ETO06675.1 - 0.013 14.5 1.9 0.015 14.3 0.8 1.5 1 1 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region DJ-1_PfpI PF01965.24 ETO06677.1 - 9.7e-08 32.0 0.1 7e-07 29.2 0.0 2.4 2 2 1 3 3 3 1 DJ-1/PfpI family DUF4530 PF15039.6 ETO06678.1 - 0.015 15.4 0.5 0.022 14.9 0.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4530) NCD2 PF04905.13 ETO06678.1 - 0.042 13.8 2.3 0.51 10.3 0.1 2.1 1 1 0 2 2 2 0 NAB conserved region 2 (NCD2) DUF1664 PF07889.12 ETO06678.1 - 0.24 11.4 2.5 0.35 10.9 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) CDC45 PF02724.14 ETO06680.1 - 0.074 11.3 16.0 0.1 10.9 16.0 1.3 1 0 0 1 1 1 0 CDC45-like protein TCO89 PF10452.9 ETO06681.1 - 1.7 7.5 9.3 1.9 7.4 9.3 1.0 1 0 0 1 1 1 0 TORC1 subunit TCO89 PfkB PF00294.24 ETO06682.1 - 5.9e-34 117.7 0.0 1.6e-33 116.3 0.0 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ETO06682.1 - 0.00013 21.4 0.0 0.00025 20.5 0.0 1.4 1 0 0 1 1 1 1 Phosphomethylpyrimidine kinase F-box PF00646.33 ETO06683.1 - 0.015 15.2 0.0 0.041 13.8 0.0 1.7 1 0 0 1 1 1 0 F-box domain Pep_deformylase PF01327.21 ETO06684.1 - 0.045 13.3 1.8 0.25 10.9 0.5 2.2 2 0 0 2 2 2 0 Polypeptide deformylase Cadherin_C_2 PF16492.5 ETO06685.1 - 0.092 13.5 1.2 0.15 12.8 0.0 1.9 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF3839 PF12943.7 ETO06686.1 - 1.3e-05 24.8 1.7 2.1e-05 24.1 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3839) Geminin PF07412.12 ETO06686.1 - 0.0072 16.1 2.5 0.011 15.5 2.5 1.3 1 0 0 1 1 1 1 Geminin DUF641 PF04859.12 ETO06686.1 - 0.61 10.4 6.6 0.78 10.1 6.3 1.4 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) HAND PF09110.11 ETO06688.1 - 0.092 13.5 0.1 0.11 13.3 0.1 1.1 1 0 0 1 1 1 0 HAND zf-RanBP PF00641.18 ETO06689.1 - 0.00024 20.4 0.5 0.00044 19.5 0.5 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO06689.1 - 0.049 13.0 0.3 0.12 11.8 0.3 1.7 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ETO06689.1 - 0.13 12.4 0.8 0.2 11.8 0.1 1.7 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger MyTH4 PF00784.17 ETO06690.1 - 2.7e-05 24.6 0.4 4.1e-05 24.0 0.4 1.5 1 1 0 1 1 1 1 MyTH4 domain Tox-REase-3 PF15647.6 ETO06690.1 - 0.11 12.7 0.1 0.16 12.3 0.1 1.2 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 3 Sde2_N_Ubi PF13019.6 ETO06692.1 - 6.3e-11 42.4 0.6 9.2e-11 41.8 0.6 1.3 1 0 0 1 1 1 1 Silencing defective 2 N-terminal ubiquitin domain FAM60A PF15396.6 ETO06692.1 - 0.00035 20.6 0.4 0.00044 20.3 0.4 1.1 1 0 0 1 1 1 1 Protein Family FAM60A Efg1 PF10153.9 ETO06692.1 - 0.02 15.2 2.6 0.028 14.8 2.6 1.1 1 0 0 1 1 1 0 rRNA-processing protein Efg1 PBP1_TM PF14812.6 ETO06692.1 - 2.9 8.3 10.8 8.3 6.9 10.8 1.7 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4100 PF13352.6 ETO06693.1 - 0.004 17.0 0.5 0.004 17.0 0.5 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF4100) TBPIP_N PF15517.6 ETO06694.1 - 0.17 11.9 0.9 19 5.4 0.0 2.6 3 0 0 3 3 3 0 TBP-interacting protein N-terminus Ndc1_Nup PF09531.10 ETO06696.1 - 0.021 13.5 6.8 0.023 13.4 6.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AcetylCoA_hyd_C PF13336.6 ETO06696.1 - 0.32 10.9 2.9 0.46 10.4 2.9 1.2 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain FSA_C PF10479.9 ETO06696.1 - 1.4 7.0 16.8 1.6 6.8 16.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Plasmodium_Vir PF05795.11 ETO06696.1 - 5.6 6.3 14.4 7.4 5.9 14.4 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Mitofilin PF09731.9 ETO06696.1 - 6.2 5.5 24.3 7.3 5.3 24.3 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein NDUF_B4 PF07225.12 ETO06698.1 - 0.05 13.5 0.5 0.12 12.3 0.3 1.6 1 1 0 1 1 1 0 NADH-ubiquinone oxidoreductase B15 subunit (NDUFB4) WD40 PF00400.32 ETO06700.1 - 2.3e-38 129.5 27.4 2.5e-06 28.1 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06700.1 - 3.5e-13 49.7 1.9 0.0011 19.2 0.0 5.7 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06700.1 - 1.4e-06 27.3 8.9 0.046 12.4 0.5 4.8 3 2 0 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06700.1 - 4.3e-05 23.0 6.2 0.0072 15.7 0.9 3.9 3 1 1 4 4 4 3 WD40-like domain zf-TRAF PF02176.18 ETO06700.1 - 0.0002 22.0 2.8 0.0002 22.0 2.8 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger BBS2_Mid PF14783.6 ETO06700.1 - 0.00039 20.4 1.7 17 5.5 0.1 5.3 5 1 0 5 5 5 1 Ciliary BBSome complex subunit 2, middle region DUF1652 PF07865.11 ETO06700.1 - 0.079 12.8 0.5 29 4.6 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1652) Kelch_5 PF13854.6 ETO06701.1 - 0.00027 20.9 0.1 0.43 10.6 0.0 2.2 2 0 0 2 2 2 2 Kelch motif N_Asn_amidohyd PF14736.6 ETO06701.1 - 0.042 13.0 0.0 0.05 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein N-terminal asparagine amidohydrolase Kelch_6 PF13964.6 ETO06701.1 - 0.048 14.0 0.1 0.63 10.4 0.0 2.2 2 0 0 2 2 2 0 Kelch motif SAM_1 PF00536.30 ETO06702.1 - 0.0069 16.8 0.0 0.014 15.8 0.0 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF443 PF04276.12 ETO06703.1 - 0.0021 17.9 0.4 0.0038 17.0 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF443) Viral_Beta_CD PF04530.12 ETO06703.1 - 0.0056 17.0 0.1 0.0084 16.4 0.1 1.3 1 0 0 1 1 1 1 Viral Beta C/D like family RCR PF12273.8 ETO06703.1 - 0.15 12.7 0.1 0.26 11.9 0.1 1.4 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red NVEALA PF14055.6 ETO06703.1 - 0.2 11.7 1.2 0.35 10.9 0.2 1.8 2 0 0 2 2 2 0 NVEALA protein ETRAMP PF09716.10 ETO06703.1 - 0.89 9.7 2.8 7.5 6.7 0.1 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PUB PF09409.10 ETO06704.1 - 0.0056 16.6 0.0 0.011 15.7 0.0 1.5 1 0 0 1 1 1 1 PUB domain Choline_sulf_C PF12411.8 ETO06705.1 - 0.012 15.4 0.7 0.08 12.8 0.1 2.4 3 0 0 3 3 3 0 Choline sulfatase enzyme C terminal MAJIN PF15077.6 ETO06706.1 - 0.00032 20.6 8.8 0.00043 20.2 8.8 1.1 1 0 0 1 1 1 1 Membrane-anchored junction protein SLC12 PF03522.15 ETO06706.1 - 0.00083 18.5 11.1 0.00098 18.2 11.1 1.1 1 0 0 1 1 1 1 Solute carrier family 12 EOS1 PF12326.8 ETO06706.1 - 0.00086 19.3 7.3 0.09 12.7 7.3 2.1 1 1 0 1 1 1 1 N-glycosylation protein TERB2 PF15101.6 ETO06706.1 - 0.0014 18.7 7.7 0.0017 18.4 7.7 1.1 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Hid1 PF12722.7 ETO06706.1 - 0.0018 16.5 4.3 0.0021 16.3 4.3 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein DUF913 PF06025.12 ETO06706.1 - 0.0076 15.3 8.0 0.0099 14.9 8.0 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO06706.1 - 0.0084 15.4 0.8 0.0093 15.2 0.8 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 ETO06706.1 - 0.019 13.4 7.8 0.023 13.1 7.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NPR3 PF03666.13 ETO06706.1 - 0.032 13.0 16.7 0.038 12.8 16.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 ETO06706.1 - 0.042 13.9 5.8 0.057 13.5 5.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO06706.1 - 0.059 11.7 13.7 0.069 11.4 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2828 PF11443.8 ETO06706.1 - 0.073 11.2 12.1 0.1 10.7 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Gti1_Pac2 PF09729.9 ETO06706.1 - 0.079 13.0 15.0 0.11 12.5 15.0 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DUF262 PF03235.14 ETO06706.1 - 0.088 13.0 9.7 0.11 12.6 9.7 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 FAM60A PF15396.6 ETO06706.1 - 0.16 12.0 17.7 0.22 11.5 17.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A BORG_CEP PF14957.6 ETO06706.1 - 0.22 12.7 4.5 0.33 12.1 4.5 1.3 1 0 0 1 1 1 0 Cdc42 effector LicD PF04991.13 ETO06706.1 - 0.24 11.5 14.8 0.34 11.0 14.8 1.3 1 0 0 1 1 1 0 LicD family DUF4746 PF15928.5 ETO06706.1 - 0.37 10.2 17.9 0.49 9.8 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPL5 PF18168.1 ETO06706.1 - 0.88 8.8 13.7 1.2 8.4 13.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF5427 PF10310.9 ETO06706.1 - 0.95 8.3 18.8 1.2 8.0 18.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) XRN_M PF17846.1 ETO06706.1 - 0.99 8.3 14.2 1.2 8.0 14.2 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Spem1 PF15670.5 ETO06706.1 - 1 8.9 12.2 1.7 8.2 12.2 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 MCM_bind PF09739.9 ETO06706.1 - 1.2 7.5 16.2 1.6 7.0 16.2 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RR_TM4-6 PF06459.12 ETO06706.1 - 2 8.2 21.0 2.9 7.6 21.0 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 ETO06706.1 - 2.3 8.5 27.7 3.7 7.9 27.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CLN3 PF02487.17 ETO06706.1 - 4 6.4 8.7 6.6 5.7 8.7 1.4 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 ETO06706.1 - 5.9 6.3 23.5 10 5.6 23.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Band_3_cyto PF07565.13 ETO06706.1 - 6.5 6.5 10.5 8.4 6.1 10.5 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF4569 PF15133.6 ETO06706.1 - 7.3 6.2 13.9 9.4 5.9 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) PPC PF04151.15 ETO06709.1 - 0.0092 17.1 0.2 0.0092 17.1 0.2 4.8 3 2 0 4 4 4 1 Bacterial pre-peptidase C-terminal domain ARID PF01388.21 ETO06711.1 - 2.8e-13 50.3 0.4 4.6e-13 49.7 0.4 1.3 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain PHD PF00628.29 ETO06711.1 - 0.00022 21.1 7.3 0.00057 19.7 7.4 1.7 1 1 0 1 1 1 1 PHD-finger C1_1 PF00130.22 ETO06711.1 - 0.0024 17.7 1.4 0.0024 17.7 1.4 2.9 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 ETO06711.1 - 0.0075 16.2 1.7 0.0075 16.2 1.7 1.7 2 0 0 2 2 2 1 Prokaryotic RING finger family 1 Pox_D5 PF03288.16 ETO06711.1 - 0.11 13.0 0.1 0.22 12.0 0.1 1.5 1 0 0 1 1 1 0 Poxvirus D5 protein-like Macoilin PF09726.9 ETO06714.1 - 0.012 14.3 0.6 0.01 14.5 0.6 1.2 1 0 0 1 1 1 0 Macoilin family RP-C_C PF11800.8 ETO06714.1 - 0.02 15.0 1.0 0.036 14.2 1.0 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region IMUP PF15761.5 ETO06714.1 - 0.51 11.0 14.1 0.76 10.5 14.1 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein CTU2 PF10288.9 ETO06714.1 - 0.9 9.8 6.8 4.1 7.7 2.1 2.2 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 TerB_C PF15615.6 ETO06714.1 - 1.6 9.0 5.3 0.14 12.5 0.7 1.5 2 0 0 2 2 2 0 TerB-C domain DUF4171 PF13775.6 ETO06714.1 - 6.3 7.3 16.7 10 6.6 16.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4171) Dynamitin PF04912.14 ETO06715.1 - 0.0012 18.3 1.3 0.0022 17.4 1.3 1.4 1 0 0 1 1 1 1 Dynamitin DUF5436 PF17504.2 ETO06715.1 - 0.57 10.5 2.5 1 9.7 2.5 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5436) DUF2326 PF10088.9 ETO06717.1 - 0.024 14.4 0.5 0.035 13.8 0.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein conserved in bacteria (DUF2326) TMPIT PF07851.13 ETO06722.1 - 4.5e-57 193.7 17.5 1.6e-45 155.8 12.4 2.0 1 1 1 2 2 2 2 TMPIT-like protein Fib_alpha PF08702.10 ETO06722.1 - 0.0086 16.3 6.2 0.017 15.3 6.2 1.4 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family Nmad5 PF18757.1 ETO06722.1 - 0.014 15.6 3.2 0.02 15.1 3.2 1.2 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 DUF842 PF05811.13 ETO06722.1 - 0.023 14.4 2.6 0.043 13.5 2.6 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF842) Myosin_tail_1 PF01576.19 ETO06722.1 - 0.026 12.4 6.1 0.034 12.0 6.1 1.1 1 0 0 1 1 1 0 Myosin tail YojJ PF10372.9 ETO06722.1 - 0.036 14.2 1.2 0.036 14.2 1.2 2.0 2 1 0 2 2 1 0 Bacterial membrane-spanning protein N-terminus LemA PF04011.12 ETO06722.1 - 0.082 12.8 2.5 0.11 12.3 0.7 1.9 1 1 1 2 2 2 0 LemA family COG5 PF10392.9 ETO06722.1 - 0.15 12.3 2.7 0.28 11.3 0.7 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 Seryl_tRNA_N PF02403.22 ETO06722.1 - 0.25 11.6 8.0 0.7 10.1 7.0 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Colicin PF01024.19 ETO06722.1 - 0.28 11.1 2.2 0.41 10.5 2.2 1.2 1 0 0 1 1 1 0 Colicin pore forming domain CTP_transf_1 PF01148.20 ETO06722.1 - 0.3 10.8 4.0 0.31 10.8 2.1 1.7 1 1 1 2 2 2 0 Cytidylyltransferase family P4Ha_N PF08336.11 ETO06722.1 - 0.34 10.9 4.2 0.52 10.3 4.2 1.3 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Phage_GPO PF05929.11 ETO06722.1 - 0.56 9.8 3.9 0.79 9.3 3.9 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Spc7 PF08317.11 ETO06722.1 - 0.74 8.6 11.1 1.2 8.0 11.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DASH_Dad2 PF08654.10 ETO06722.1 - 0.89 10.0 4.4 6.9 7.2 4.7 2.3 2 1 0 2 2 2 0 DASH complex subunit Dad2 FapA PF03961.13 ETO06722.1 - 2.6 6.5 8.3 3.5 6.1 8.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 ETO06722.1 - 3.4 8.0 7.8 7.8 6.8 7.8 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Uso1_p115_C PF04871.13 ETO06722.1 - 4.3 7.7 8.7 9.8 6.6 8.7 1.5 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF5427 PF10310.9 ETO06724.1 - 0.05 12.6 6.4 0.056 12.4 6.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SCAI PF12070.8 ETO06724.1 - 0.23 10.3 1.3 0.27 10.0 1.3 1.0 1 0 0 1 1 1 0 Protein SCAI Podoplanin PF05808.11 ETO06724.1 - 0.37 10.9 4.2 0.44 10.7 4.2 1.1 1 0 0 1 1 1 0 Podoplanin RNA_pol_Rpc4 PF05132.14 ETO06724.1 - 0.59 10.6 6.2 0.75 10.2 6.2 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4834 PF16118.5 ETO06724.1 - 0.82 10.7 3.9 1.1 10.3 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Vg_Tdu PF07545.14 ETO06724.1 - 1.3 8.8 3.0 0.69 9.7 0.9 1.6 2 0 0 2 2 2 0 Vestigial/Tondu family CobT PF06213.12 ETO06724.1 - 1.7 8.0 9.2 2.1 7.7 9.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AIF_C PF14721.6 ETO06724.1 - 1.9 8.8 7.3 10 6.5 7.3 1.8 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PGA2 PF07543.12 ETO06724.1 - 2.1 8.3 9.2 2.7 8.0 9.2 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 Pup PF05639.11 ETO06724.1 - 4.4 8.3 11.9 19 6.3 10.5 2.4 1 1 0 1 1 1 0 Pup-like protein Presenilin PF01080.17 ETO06724.1 - 5.7 5.6 5.3 6.7 5.4 5.3 1.0 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 ETO06724.1 - 7 5.9 9.2 8.5 5.7 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Annexin PF00191.20 ETO06725.1 - 6e-22 77.5 4.2 1.9e-05 24.6 0.1 4.4 4 0 0 4 4 4 4 Annexin DUF4922 PF16269.5 ETO06726.1 - 0.0034 17.2 0.1 0.0069 16.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4922) AAA_2 PF07724.14 ETO06726.1 - 0.048 13.8 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) VIR_N PF15912.5 ETO06727.1 - 2.4 7.7 12.7 4 7.0 12.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal DUF3439 PF11921.8 ETO06728.1 - 0.045 13.7 2.1 0.072 13.1 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) adh_short_C2 PF13561.6 ETO06729.1 - 7.5e-55 186.0 1.7 6.8e-54 182.9 1.7 1.9 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO06729.1 - 2.2e-43 148.0 0.9 3.1e-43 147.5 0.9 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO06729.1 - 9.5e-08 32.2 0.8 7.6e-07 29.2 0.6 2.0 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ETO06729.1 - 4.8e-05 22.9 0.5 8.9e-05 22.1 0.5 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family THF_DHG_CYH_C PF02882.19 ETO06729.1 - 0.0012 18.2 0.3 0.0012 18.2 0.3 1.6 2 0 0 2 2 2 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain GDP_Man_Dehyd PF16363.5 ETO06729.1 - 0.0086 15.5 0.1 0.012 15.0 0.1 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_10 PF13460.6 ETO06729.1 - 0.017 15.0 1.1 0.11 12.4 1.0 2.0 2 0 0 2 2 2 0 NAD(P)H-binding 3HCDH_N PF02737.18 ETO06729.1 - 0.019 14.9 1.3 0.029 14.3 1.3 1.3 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 2-Hacid_dh_C PF02826.19 ETO06729.1 - 0.02 14.3 0.2 0.034 13.5 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 ETO06729.1 - 0.077 13.1 2.2 0.64 10.1 2.9 2.1 2 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain ApbA PF02558.16 ETO06729.1 - 0.089 12.4 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Polysacc_deac_2 PF04748.13 ETO06729.1 - 0.13 11.4 0.0 0.21 10.7 0.0 1.3 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Helicase_RecD PF05127.14 ETO06729.1 - 0.15 11.9 0.4 0.36 10.7 0.4 1.6 1 1 0 1 1 1 0 Helicase DUF4746 PF15928.5 ETO06732.1 - 0.0044 16.5 11.0 0.0058 16.1 11.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) CENP-B_dimeris PF09026.10 ETO06732.1 - 0.012 16.0 0.9 0.021 15.2 0.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Myc_N PF01056.18 ETO06732.1 - 0.02 14.8 5.4 0.022 14.7 5.4 1.3 1 0 0 1 1 1 0 Myc amino-terminal region Bestrophin PF01062.21 ETO06732.1 - 0.035 13.5 0.8 0.048 13.0 0.8 1.3 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel MscS_TM PF12794.7 ETO06732.1 - 0.21 10.4 1.1 0.29 10.0 1.1 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 IIGP PF05049.13 ETO06734.1 - 0.036 13.1 0.1 0.057 12.5 0.1 1.3 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) DUF4548 PF15081.6 ETO06734.1 - 0.073 12.9 1.2 0.13 12.0 1.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4548) Borrelia_lipo_1 PF05714.11 ETO06734.1 - 0.18 11.5 4.5 0.045 13.5 1.3 1.6 2 0 0 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein MAGI_u5 PF16666.5 ETO06734.1 - 0.41 10.8 6.2 0.19 11.8 3.8 1.7 2 0 0 2 2 2 0 Unstructured region on MAGI PDZ_3 PF17815.1 ETO06735.1 - 4.3e-38 130.4 0.0 6.7e-38 129.8 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Trypsin_2 PF13365.6 ETO06735.1 - 1e-19 71.9 0.2 1.8e-19 71.1 0.2 1.4 1 0 0 1 1 1 1 Trypsin-like peptidase domain Trypsin PF00089.26 ETO06735.1 - 1.3e-12 48.0 0.8 2.1e-12 47.3 0.8 1.3 1 0 0 1 1 1 1 Trypsin PDZ_2 PF13180.6 ETO06735.1 - 9.2e-05 22.7 0.0 0.00021 21.6 0.0 1.7 1 0 0 1 1 1 1 PDZ domain DUF5362 PF17319.2 ETO06736.1 - 0.073 12.9 0.0 0.13 12.1 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5362) CDC45 PF02724.14 ETO06736.1 - 3.6 5.8 14.3 4.5 5.5 14.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 ETO06737.1 - 0.00036 20.0 0.0 0.00066 19.1 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain 7tm_1 PF00001.21 ETO06738.1 - 0.0067 15.8 0.0 0.0067 15.8 0.0 2.1 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) WBP-1 PF11669.8 ETO06738.1 - 0.14 12.8 0.1 0.14 12.8 0.1 3.2 2 1 1 3 3 3 0 WW domain-binding protein 1 DUF4064 PF13273.6 ETO06738.1 - 1.3 9.3 2.7 0.79 10.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) CENP-B_dimeris PF09026.10 ETO06738.1 - 7.3 7.0 10.7 5.2 7.5 2.1 3.1 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Epimerase PF01370.21 ETO06739.1 - 3.1e-15 56.3 0.0 3.9e-15 56.0 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ETO06739.1 - 1.7e-14 54.1 0.0 2e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ETO06739.1 - 6.2e-10 38.5 0.0 8.2e-10 38.1 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family GDP_Man_Dehyd PF16363.5 ETO06739.1 - 1.2e-08 34.7 0.0 1.6e-08 34.4 0.0 1.2 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ETO06739.1 - 1.1e-05 25.1 0.0 3.7e-05 23.4 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ETO06739.1 - 0.0012 18.4 0.0 0.0019 17.7 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 ETO06739.1 - 0.043 13.0 0.1 0.08 12.1 0.1 1.8 1 1 0 1 1 1 0 Male sterility protein adh_short_C2 PF13561.6 ETO06739.1 - 0.085 12.4 0.0 0.18 11.4 0.0 1.5 2 0 0 2 2 2 0 Enoyl-(Acyl carrier protein) reductase SASP PF00269.20 ETO06739.1 - 0.15 12.1 0.0 0.29 11.2 0.0 1.4 1 0 0 1 1 1 0 Small, acid-soluble spore proteins, alpha/beta type Ras PF00071.22 ETO06740.1 - 2e-20 73.0 0.5 2.7e-20 72.6 0.5 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO06740.1 - 0.0032 17.7 0.6 0.0049 17.1 0.1 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETO06741.1 - 5.3e-26 91.8 1.9 7.2e-26 91.3 0.0 2.0 2 1 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ETO06741.1 - 6.5e-06 26.5 0.1 5.9e-05 23.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain SMC_N PF02463.19 ETO06741.1 - 1.7e-05 24.4 0.4 0.018 14.5 0.1 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETO06741.1 - 8.1e-05 23.1 0.1 0.00016 22.1 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO06741.1 - 0.00042 20.0 0.0 0.001 18.8 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA PF00004.29 ETO06741.1 - 0.00064 20.2 0.1 0.18 12.3 0.2 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_21 PF13304.6 ETO06741.1 - 0.0046 16.8 0.1 0.45 10.3 0.0 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ETO06741.1 - 0.0056 16.4 2.4 0.23 11.1 2.4 2.3 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO06741.1 - 0.006 16.5 0.1 0.034 14.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase ThiS PF02597.20 ETO06741.1 - 0.015 15.9 0.2 0.051 14.2 0.2 1.9 1 0 0 1 1 1 0 ThiS family AAA_33 PF13671.6 ETO06741.1 - 0.017 15.3 1.1 0.054 13.7 0.1 2.3 2 2 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETO06741.1 - 0.019 14.5 0.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ETO06741.1 - 0.02 14.9 0.4 0.38 10.8 0.0 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ETO06741.1 - 0.02 14.6 0.0 0.7 9.6 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO06741.1 - 0.024 15.2 0.2 0.11 13.0 0.0 2.2 2 2 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO06741.1 - 0.03 14.1 0.0 0.37 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ETO06741.1 - 0.041 14.0 2.4 0.67 10.0 0.0 2.4 2 1 0 2 2 2 0 Helicase HerA, central domain TniB PF05621.11 ETO06741.1 - 0.046 13.1 0.0 5.5 6.4 0.0 2.3 2 0 0 2 2 2 0 Bacterial TniB protein Rad17 PF03215.15 ETO06741.1 - 0.054 13.4 0.0 0.13 12.1 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain IstB_IS21 PF01695.17 ETO06741.1 - 0.066 12.9 0.1 1.2 8.8 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_17 PF13207.6 ETO06741.1 - 0.068 13.6 0.8 5.3 7.5 0.0 2.9 2 1 1 3 3 3 0 AAA domain Glyco_hydro_79n PF03662.14 ETO06741.1 - 0.069 12.1 0.0 0.097 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 79, N-terminal domain Lactamase_B_5 PF14597.6 ETO06741.1 - 0.072 12.6 0.8 0.15 11.5 0.8 1.5 1 1 0 1 1 1 0 Metallo-beta-lactamase superfamily AAA_23 PF13476.6 ETO06741.1 - 0.48 10.9 7.3 1.6 9.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain zf-TRAF PF02176.18 ETO06742.1 - 0.00053 20.6 2.2 0.00053 20.6 2.2 2.6 2 1 0 2 2 2 1 TRAF-type zinc finger zf-RING-like PF08746.11 ETO06742.1 - 0.015 15.6 0.0 0.27 11.6 0.0 3.9 3 2 1 4 4 4 0 RING-like domain RasGEF PF00617.19 ETO06743.1 - 1.7e-08 34.9 0.0 3.1e-08 34.0 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain WVELL PF14043.6 ETO06743.1 - 0.091 12.6 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 WVELL protein PIP5K PF01504.18 ETO06744.1 - 2e-32 112.5 0.1 2.8e-32 112.1 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PIP5K PF01504.18 ETO06745.1 - 6.9e-34 117.3 1.2 6.9e-34 117.3 1.2 2.0 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase ALIX_LYPXL_bnd PF13949.6 ETO06747.1 - 2e-36 125.8 7.7 2.2e-36 125.7 7.7 1.0 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Cpn60_TCP1 PF00118.24 ETO06747.1 - 0.01 14.5 1.2 0.015 13.9 0.9 1.5 1 1 1 2 2 2 0 TCP-1/cpn60 chaperonin family ZapB PF06005.12 ETO06747.1 - 0.024 15.1 2.9 0.073 13.5 2.9 1.8 1 0 0 1 1 1 0 Cell division protein ZapB Taxilin PF09728.9 ETO06747.1 - 0.026 13.7 9.0 0.055 12.6 9.0 1.8 1 1 0 1 1 1 0 Myosin-like coiled-coil protein DOPA_dioxygen PF08883.11 ETO06747.1 - 0.092 12.9 0.2 0.9 9.7 0.0 2.3 2 0 0 2 2 2 0 Dopa 4,5-dioxygenase family Dynein_light PF01221.18 ETO06747.1 - 0.19 12.0 4.8 8.9 6.7 0.1 3.4 3 1 0 4 4 4 0 Dynein light chain type 1 UPF0242 PF06785.11 ETO06747.1 - 3 7.9 9.8 19 5.3 6.9 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PI3K_1B_p101 PF10486.9 ETO06748.1 - 1.2 6.8 8.1 1.3 6.7 8.1 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Rimk_N PF18030.1 ETO06749.1 - 0.00025 21.4 0.0 0.037 14.4 0.0 2.6 1 1 1 2 2 2 1 RimK PreATP-grasp domain DUF359 PF04019.12 ETO06749.1 - 0.11 12.1 0.3 0.62 9.7 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF359) Spt20 PF12090.8 ETO06749.1 - 0.36 10.4 16.0 0.02 14.5 9.6 1.9 2 0 0 2 2 2 0 Spt20 family Androgen_recep PF02166.16 ETO06749.1 - 2.7 6.8 10.6 0.11 11.3 4.1 1.8 2 0 0 2 2 2 0 Androgen receptor DUF4834 PF16118.5 ETO06749.1 - 3.4 8.7 6.9 1.4 9.9 2.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ATG16 PF08614.11 ETO06750.1 - 0.038 14.2 1.6 0.038 14.2 1.6 3.5 3 1 0 4 4 4 0 Autophagy protein 16 (ATG16) Wtap PF17098.5 ETO06750.1 - 5.6 6.9 27.1 10 6.0 0.1 3.8 3 1 1 4 4 4 0 WTAP/Mum2p family Macoilin PF09726.9 ETO06750.1 - 7.6 4.9 24.1 12 4.3 24.1 1.3 1 1 0 1 1 1 0 Macoilin family PX PF00787.24 ETO06751.1 - 0.055 13.5 0.1 0.073 13.1 0.1 1.4 1 0 0 1 1 1 0 PX domain DUF4407 PF14362.6 ETO06752.1 - 0.00021 20.8 2.2 0.00021 20.8 2.2 3.3 1 1 2 3 3 3 1 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 ETO06752.1 - 0.00055 20.0 16.2 0.00055 20.0 16.2 5.8 2 1 3 6 6 6 3 TPR/MLP1/MLP2-like protein HALZ PF02183.18 ETO06752.1 - 0.0016 18.6 6.9 0.032 14.5 0.0 3.8 3 1 0 3 3 3 1 Homeobox associated leucine zipper Snapin_Pallidin PF14712.6 ETO06752.1 - 0.0079 16.6 14.7 0.0079 16.6 14.7 5.4 4 2 0 5 5 5 1 Snapin/Pallidin Cep57_CLD_2 PF14197.6 ETO06752.1 - 0.013 15.6 6.7 0.013 15.6 6.7 5.9 4 2 2 6 6 6 0 Centrosome localisation domain of PPC89 FUSC PF04632.12 ETO06752.1 - 0.25 9.9 8.6 1.2 7.6 0.3 2.5 2 1 0 2 2 2 0 Fusaric acid resistance protein family Shugoshin_N PF07558.11 ETO06752.1 - 1.1 9.2 16.7 0.29 11.0 3.4 4.7 3 1 0 3 3 3 0 Shugoshin N-terminal coiled-coil region HrpB7 PF09486.10 ETO06752.1 - 2.7 8.4 41.5 0.57 10.6 0.3 5.4 3 2 2 5 5 5 0 Bacterial type III secretion protein (HrpB7) DUF4179 PF13786.6 ETO06753.1 - 0.066 13.7 0.3 0.16 12.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4179) BAF1_ABF1 PF04684.13 ETO06753.1 - 0.91 8.5 13.8 0.81 8.7 12.5 1.4 1 1 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hydrolase_4 PF12146.8 ETO06754.1 - 1.1e-11 44.5 0.1 1.3e-05 24.6 0.0 2.1 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO06754.1 - 2.9e-07 30.4 0.2 0.00077 19.2 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETO06754.1 - 1.2e-06 28.2 0.0 1.4e-05 24.7 0.0 2.1 1 1 0 1 1 1 1 Prolyl oligopeptidase family FSH1 PF03959.13 ETO06754.1 - 8.6e-05 22.3 0.0 0.00014 21.6 0.0 1.4 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S15 PF02129.18 ETO06754.1 - 0.002 17.8 0.0 2.2 7.8 0.0 2.3 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_4 PF08386.10 ETO06754.1 - 0.016 15.3 0.0 0.051 13.7 0.0 1.7 1 1 0 2 2 2 0 TAP-like protein Abhydrolase_2 PF02230.16 ETO06754.1 - 0.016 15.0 0.1 4.8 6.9 0.0 2.4 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Esterase PF00756.20 ETO06754.1 - 0.049 13.3 0.1 0.057 13.1 0.1 1.3 1 1 0 1 1 1 0 Putative esterase Tannase PF07519.11 ETO06754.1 - 0.051 12.5 0.0 0.27 10.1 0.0 1.9 2 0 0 2 2 2 0 Tannase and feruloyl esterase DLH PF01738.18 ETO06754.1 - 0.084 12.4 0.0 1.2 8.6 0.0 2.0 2 0 0 2 2 2 0 Dienelactone hydrolase family RtcB PF01139.17 ETO06755.1 - 2.4e-51 175.2 0.0 2.9e-51 174.9 0.0 1.0 1 0 0 1 1 1 1 tRNA-splicing ligase RtcB Gly_transf_sug PF04488.15 ETO06756.1 - 2.3e-08 34.5 0.1 2.3e-08 34.5 0.1 3.7 3 1 1 4 4 4 1 Glycosyltransferase sugar-binding region containing DXD motif zf-C3HC4_3 PF13920.6 ETO06756.1 - 4.6e-08 32.8 10.9 4.6e-08 32.8 10.9 3.3 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO06756.1 - 0.00091 19.0 10.0 0.016 15.1 10.0 2.8 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C2H2 PF00096.26 ETO06757.1 - 0.0003 21.1 2.0 0.0003 21.1 2.0 3.7 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf_UBZ PF18439.1 ETO06757.1 - 0.0016 18.0 3.9 0.027 14.1 0.9 2.7 2 0 0 2 2 2 1 Ubiquitin-Binding Zinc Finger zf-H2C2_2 PF13465.6 ETO06757.1 - 0.0085 16.5 0.1 0.0085 16.5 0.1 5.3 5 1 0 5 5 5 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO06757.1 - 0.011 16.5 8.4 0.051 14.4 0.9 3.8 4 0 0 4 4 4 0 C2H2-type zinc finger TFIIS_C PF01096.18 ETO06757.1 - 0.012 15.4 6.2 1.1 9.2 0.1 3.0 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Zn-ribbon_8 PF09723.10 ETO06757.1 - 0.33 11.1 10.6 1.2 9.3 1.9 3.4 3 0 0 3 3 3 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 ETO06757.1 - 0.95 9.5 6.7 0.91 9.6 0.3 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger FKBP_N PF01346.18 ETO06757.1 - 1.3 10.1 6.7 2.4 9.1 6.7 1.4 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase RNA_pol_Rpb4 PF03874.16 ETO06757.1 - 3.3 8.1 10.6 2 8.8 8.6 1.6 2 0 0 2 2 2 0 RNA polymerase Rpb4 C1_4 PF07975.12 ETO06757.1 - 5.5 7.3 11.0 0.9 9.8 1.9 3.2 3 1 0 3 3 3 0 TFIIH C1-like domain DUF3439 PF11921.8 ETO06758.1 - 3.3 7.7 13.0 5.9 6.9 13.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MAGE_N PF12440.8 ETO06758.1 - 8.6 7.1 9.9 25 5.6 9.9 1.9 1 1 0 1 1 1 0 Melanoma associated antigen family N terminal ANAPC4_WD40 PF12894.7 ETO06759.1 - 0.0027 18.0 6.3 0.68 10.3 0.2 5.4 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO06759.1 - 0.031 15.1 20.5 25 6.0 1.2 7.2 7 0 0 7 7 7 0 WD domain, G-beta repeat DUF3336 PF11815.8 ETO06760.1 - 1.4e-06 28.0 0.3 2e-06 27.6 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Cyd_oper_YbgE PF09600.10 ETO06760.1 - 0.087 13.2 4.9 0.86 10.0 0.7 2.8 2 1 1 3 3 3 0 Cyd operon protein YbgE (Cyd_oper_YbgE) Patatin PF01734.22 ETO06761.1 - 5.2e-14 52.9 3.1 9.4e-10 39.0 0.0 2.9 4 0 0 4 4 4 2 Patatin-like phospholipase DUF3336 PF11815.8 ETO06761.1 - 1.6e-10 40.9 0.3 3.4e-10 39.8 0.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Secretin_N_2 PF07655.13 ETO06761.1 - 0.0019 18.7 8.4 0.0019 18.7 8.4 2.9 2 0 0 2 2 2 1 Secretin N-terminal domain Corona_nucleoca PF00937.18 ETO06761.1 - 0.003 16.7 4.0 0.0056 15.8 4.0 1.4 1 0 0 1 1 1 1 Coronavirus nucleocapsid protein Menin PF05053.13 ETO06761.1 - 0.016 13.6 6.4 0.031 12.7 6.4 1.4 1 0 0 1 1 1 0 Menin SSP160 PF06933.11 ETO06761.1 - 3.7 5.6 10.5 5.7 5.0 10.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DDHD PF02862.17 ETO06761.1 - 7.3 6.7 10.5 0.16 12.1 0.8 2.4 3 0 0 3 3 3 0 DDHD domain Metallophos PF00149.28 ETO06762.1 - 6.2e-35 121.5 0.1 6.2e-35 121.5 0.1 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO06762.1 - 1.7e-09 38.0 1.7 2.3e-08 34.3 1.3 2.6 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Profilin PF00235.19 ETO06763.1 - 0.00066 19.9 0.1 0.00079 19.7 0.1 1.2 1 0 0 1 1 1 1 Profilin G-alpha PF00503.20 ETO06764.1 - 2.5e-35 122.3 2.9 1.5e-34 119.7 2.9 1.9 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO06764.1 - 1.3e-06 28.0 0.1 0.0046 16.4 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO06764.1 - 0.025 14.8 2.1 0.18 12.0 0.3 3.0 3 1 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Rad17 PF03215.15 ETO06764.1 - 0.042 13.8 1.1 0.24 11.3 0.2 2.4 2 1 1 3 3 3 0 Rad17 P-loop domain ABC_tran PF00005.27 ETO06764.1 - 0.044 14.3 0.0 0.071 13.6 0.0 1.4 1 0 0 1 1 1 0 ABC transporter DUF3397 PF11877.8 ETO06764.1 - 0.56 10.4 5.5 0.91 9.7 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3397) Ribophorin_II PF05817.14 ETO06765.1 - 7.8e-55 186.6 3.8 1.2e-54 185.9 3.8 1.2 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit Ribophorin II zf-TRAF PF02176.18 ETO06767.1 - 4.4e-06 27.3 1.4 4.4e-06 27.3 1.4 2.7 3 0 0 3 3 3 1 TRAF-type zinc finger YmdB PF13277.6 ETO06767.1 - 0.092 12.1 0.0 1.8 7.9 0.0 2.2 2 0 0 2 2 2 0 YmdB-like protein PRA1 PF03208.19 ETO06769.1 - 0.064 12.9 4.1 0.081 12.6 1.0 2.3 2 0 0 2 2 2 0 PRA1 family protein Neur_chan_memb PF02932.16 ETO06769.1 - 0.75 9.8 10.5 1.3 9.1 2.3 3.0 3 1 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region SET PF00856.28 ETO06770.1 - 4.9e-06 27.0 2.5 0.0019 18.6 1.0 3.6 2 2 0 2 2 2 1 SET domain Chromo PF00385.24 ETO06770.1 - 2.7e-05 24.0 0.2 9.3e-05 22.3 0.2 2.0 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain PHD PF00628.29 ETO06770.1 - 0.097 12.6 6.5 0.32 10.9 6.5 2.0 1 0 0 1 1 1 0 PHD-finger zf-RING_2 PF13639.6 ETO06770.1 - 2.2 8.7 10.6 7.8 6.9 10.6 2.0 1 1 0 1 1 1 0 Ring finger domain SNF2_N PF00176.23 ETO06771.1 - 2.3e-35 122.0 9.5 3.3e-28 98.4 4.9 2.8 1 1 1 2 2 2 2 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO06771.1 - 2e-19 70.0 0.1 1.1e-18 67.6 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO06771.1 - 0.0011 18.8 0.1 0.0097 15.7 0.2 2.4 1 1 1 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO06771.1 - 0.063 13.6 0.1 0.48 10.7 0.1 2.4 1 1 0 1 1 1 0 AAA domain DUF3439 PF11921.8 ETO06771.1 - 2.6 8.0 14.7 0.11 12.4 5.5 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) PBP1_TM PF14812.6 ETO06771.1 - 9.3 6.7 22.9 0.44 11.0 3.1 3.6 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vfa1 PF08432.10 ETO06772.1 - 0.39 11.0 20.3 0.41 10.9 20.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EIIBC-GUT_N PF03612.14 ETO06772.1 - 1.7 8.4 10.4 1.8 8.2 10.4 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Afi1 PF07792.12 ETO06772.1 - 3 8.3 14.8 3.5 8.1 14.8 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PPL5 PF18168.1 ETO06772.1 - 3 7.1 12.0 3.3 6.9 12.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 SelP_N PF04592.14 ETO06772.1 - 4.6 6.6 19.0 5 6.5 19.0 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNA_pol_Rpc4 PF05132.14 ETO06772.1 - 4.7 7.6 13.5 5.2 7.5 13.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 VIR_N PF15912.5 ETO06772.1 - 5.2 6.6 12.6 5.6 6.5 12.6 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal DUF5423 PF17461.2 ETO06772.1 - 5.4 5.8 10.2 5.8 5.7 10.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5423) Connexin PF00029.19 ETO06772.1 - 6.9 6.4 11.0 7.8 6.2 11.0 1.2 1 0 0 1 1 1 0 Connexin WD40 PF00400.32 ETO06774.1 - 6.1e-59 194.6 24.2 2.9e-09 37.4 0.1 8.2 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06774.1 - 2.3e-25 88.7 3.6 0.00084 19.6 0.1 7.4 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06774.1 - 1e-14 54.3 2.5 0.00087 18.3 0.0 5.7 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06774.1 - 9.4e-08 31.1 5.0 0.11 11.1 0.0 4.9 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Kelch_4 PF13418.6 ETO06774.1 - 2.1e-07 30.9 0.6 7.1e-06 25.9 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Cytochrom_D1 PF02239.16 ETO06774.1 - 3.1e-06 26.0 0.2 0.0046 15.5 0.0 3.5 2 2 2 4 4 4 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO06774.1 - 7.1e-06 25.8 2.5 2.4 8.2 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_6 PF13964.6 ETO06774.1 - 1.8e-05 24.8 14.2 0.028 14.7 1.0 6.4 8 0 0 8 8 7 2 Kelch motif WD40_like PF17005.5 ETO06774.1 - 2.8e-05 23.6 18.5 0.0084 15.5 0.2 5.1 4 2 3 7 7 7 4 WD40-like domain Kelch_2 PF07646.15 ETO06774.1 - 4.7e-05 23.2 3.4 0.02 14.9 0.5 4.7 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO06774.1 - 0.00017 21.5 1.0 2.5 8.2 0.5 4.4 4 0 0 4 4 4 1 Kelch motif Nbas_N PF15492.6 ETO06774.1 - 0.00053 19.4 1.3 0.18 11.1 0.1 3.4 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Kelch_3 PF13415.6 ETO06774.1 - 0.015 15.6 0.0 0.31 11.4 0.0 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain Ricin_B_lectin PF00652.22 ETO06774.1 - 0.051 13.8 0.3 0.051 13.8 0.3 4.2 4 1 1 5 5 4 0 Ricin-type beta-trefoil lectin domain DUF5570 PF17731.1 ETO06774.1 - 0.11 12.5 1.9 19 5.3 0.0 4.0 2 2 3 5 5 5 0 Family of unknown function (DUF5570) Kelch_1 PF01344.25 ETO06774.1 - 0.12 12.0 3.3 4.4 7.0 0.4 3.7 4 0 0 4 4 4 0 Kelch motif Proteasome_A_N PF10584.9 ETO06774.1 - 2.6 7.8 10.1 2.8 7.7 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature MFS_1 PF07690.16 ETO06775.1 - 2.4e-20 72.8 3.0 3.7e-20 72.1 3.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO06775.1 - 7.1e-05 21.8 7.8 0.0013 17.7 1.4 2.2 1 1 1 2 2 2 2 Sugar (and other) transporter MFS_1_like PF12832.7 ETO06775.1 - 0.0004 19.4 3.9 0.00092 18.2 4.0 1.6 1 1 0 1 1 1 1 MFS_1 like family MFS_3 PF05977.13 ETO06775.1 - 0.00044 18.8 4.3 0.00075 18.0 4.3 1.3 1 0 0 1 1 1 1 Transmembrane secretion effector cNMP_binding PF00027.29 ETO06776.1 - 2.8e-24 85.0 0.0 4.1e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Cupin_1 PF00190.22 ETO06776.1 - 0.036 13.7 0.0 0.085 12.5 0.0 1.6 1 1 0 1 1 1 0 Cupin Cupin_2 PF07883.11 ETO06776.1 - 0.067 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Cupin domain TFIID-31kDa PF02291.15 ETO06777.1 - 2.8e-29 101.7 0.4 4.5e-29 101.0 0.4 1.3 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Histone PF00125.24 ETO06777.1 - 0.00033 21.0 0.5 0.0006 20.2 0.5 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 TFIID_20kDa PF03847.13 ETO06777.1 - 0.001 19.5 0.4 0.0018 18.7 0.4 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A TFIID-18kDa PF02269.16 ETO06777.1 - 0.002 18.1 0.1 0.0039 17.2 0.1 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 18kD subunit CRAL_TRIO PF00650.20 ETO06777.1 - 0.0022 17.7 0.3 0.0042 16.8 0.3 1.6 1 1 0 1 1 1 1 CRAL/TRIO domain PHD PF00628.29 ETO06778.1 - 2.6e-09 36.8 4.8 6e-09 35.7 4.8 1.6 1 0 0 1 1 1 1 PHD-finger End3 PF12761.7 ETO06778.1 - 0.014 15.5 14.1 0.014 15.5 14.1 2.1 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 PHD_4 PF16866.5 ETO06778.1 - 0.32 11.1 6.5 0.49 10.5 4.6 2.3 1 1 0 1 1 1 0 PHD-finger AAR2 PF05282.11 ETO06778.1 - 9 5.6 10.3 4.3 6.6 8.2 1.4 1 1 1 2 2 2 0 AAR2 protein RabGAP-TBC PF00566.18 ETO06779.1 - 2.7e-23 82.7 3.3 7.5e-13 48.6 0.2 6.7 4 2 2 6 6 6 2 Rab-GTPase-TBC domain Secretin_N_2 PF07655.13 ETO06779.1 - 0.0018 18.8 14.7 0.0018 18.8 14.7 6.8 7 1 0 7 7 7 4 Secretin N-terminal domain PH PF00169.29 ETO06780.1 - 3.1e-07 30.9 0.2 5.2e-07 30.1 0.2 1.4 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 ETO06780.1 - 0.0026 18.0 2.0 0.15 12.3 0.1 2.1 2 0 0 2 2 2 2 RhoGEF domain PH_11 PF15413.6 ETO06780.1 - 0.1 13.0 0.0 0.18 12.3 0.0 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain DUF4632 PF15451.6 ETO06782.1 - 0.019 15.0 0.1 0.052 13.6 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) MINDY_DUB PF04424.13 ETO06782.1 - 0.3 11.1 2.6 7.4 6.6 0.1 2.4 2 0 0 2 2 2 0 MINDY deubiquitinase DUF3750 PF12570.8 ETO06782.1 - 0.78 10.4 5.7 0.33 11.7 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3750) DUF5094 PF17015.5 ETO06782.1 - 2.3 8.3 15.9 0.53 10.4 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) DUF2514 PF10721.9 ETO06782.1 - 2.5 8.1 8.9 6.8 6.7 4.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2514) SspB PF04386.13 ETO06783.1 - 7 6.5 6.3 23 4.9 0.0 2.7 3 0 0 3 3 3 0 Stringent starvation protein B ERCC4 PF02732.15 ETO06785.1 - 8.9e-15 55.2 1.1 1.9e-14 54.2 1.1 1.6 1 0 0 1 1 1 1 ERCC4 domain G-alpha PF00503.20 ETO06786.1 - 1.4e-26 93.5 2.0 1.9e-26 93.1 2.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit FSH1 PF03959.13 ETO06787.1 - 1.9e-32 112.6 0.8 2.4e-31 109.1 0.8 2.1 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Rad17 PF03215.15 ETO06788.1 - 2.1e-05 24.5 3.7 0.0011 19.0 0.1 3.3 3 0 0 3 3 3 1 Rad17 P-loop domain AAA_16 PF13191.6 ETO06788.1 - 3.4e-05 24.3 0.0 8.1e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO06788.1 - 0.00034 21.0 0.3 0.0022 18.3 0.0 2.6 2 0 0 2 2 2 1 RNA helicase AAA PF00004.29 ETO06788.1 - 0.00045 20.6 0.0 0.0017 18.7 0.0 2.1 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO06788.1 - 0.00047 20.2 0.1 0.002 18.1 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_assoc_2 PF16193.5 ETO06788.1 - 0.0046 17.3 0.1 0.02 15.2 0.1 2.1 1 0 0 1 1 1 1 AAA C-terminal domain AAA_19 PF13245.6 ETO06788.1 - 0.0084 16.4 0.0 0.025 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO06788.1 - 0.013 15.8 0.0 0.046 14.0 0.0 2.0 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO06788.1 - 0.015 15.8 0.0 0.015 15.8 0.0 2.8 3 1 0 3 3 2 0 ABC transporter AAA_18 PF13238.6 ETO06788.1 - 0.024 15.2 2.7 0.074 13.6 0.0 2.9 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 ETO06788.1 - 0.11 12.8 0.0 0.24 11.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ETO06788.1 - 0.21 11.3 0.0 0.21 11.3 0.0 3.4 3 1 0 3 3 3 0 AAA domain DUF3987 PF13148.6 ETO06788.1 - 0.27 10.2 1.6 35 3.2 3.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) PDE4_UCR PF18100.1 ETO06788.1 - 0.4 11.3 9.8 0.46 11.1 0.1 4.1 4 0 0 4 4 3 0 Phosphodiesterase 4 upstream conserved regions (UCR) CD36 PF01130.21 ETO06789.1 - 1.1e-86 291.3 17.2 1.4e-86 290.9 17.2 1.1 1 0 0 1 1 1 1 CD36 family DUF3139 PF11337.8 ETO06790.1 - 0.23 12.2 2.2 3.5 8.3 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) FtsX PF02687.21 ETO06790.1 - 6.7 7.3 9.0 9.3 6.8 2.5 2.6 2 0 0 2 2 2 0 FtsX-like permease family Acetyltransf_16 PF05301.11 ETO06791.1 - 0.11 12.2 3.7 0.54 10.0 0.1 2.6 3 0 0 3 3 3 0 GNAT acetyltransferase, Mec-17 CENP-B_dimeris PF09026.10 ETO06792.1 - 0.068 13.6 10.8 0.19 12.2 10.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 ETO06792.1 - 0.34 10.9 7.2 0.35 10.9 5.0 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal TFIIE-A_C PF11521.8 ETO06792.1 - 0.52 10.6 11.3 0.8 10.1 7.7 2.3 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha PGA2 PF07543.12 ETO06792.1 - 6.1 6.8 9.7 2 8.4 5.5 2.0 2 0 0 2 2 2 0 Protein trafficking PGA2 TcdB_N PF12918.7 ETO06794.1 - 0.079 13.3 4.0 1.4 9.3 0.2 2.6 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain HrpB7 PF09486.10 ETO06794.1 - 0.3 11.5 8.5 0.052 13.9 3.9 1.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF641 PF04859.12 ETO06794.1 - 1.2 9.4 13.1 0.35 11.2 5.7 2.4 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Pro_CA PF00484.19 ETO06794.1 - 4.6 7.5 6.1 4.4 7.6 2.9 2.0 2 0 0 2 2 2 0 Carbonic anhydrase IDO PF01231.18 ETO06795.1 - 6.4e-28 97.7 0.3 3.4e-22 78.9 0.3 2.1 1 1 1 2 2 2 2 Indoleamine 2,3-dioxygenase Ipi1_N PF12333.8 ETO06795.1 - 0.036 14.7 0.0 0.06 13.9 0.0 1.4 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation Myco_arth_vir_N PF09610.10 ETO06795.1 - 0.059 13.5 0.4 0.11 12.6 0.4 1.5 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Clat_adaptor_s PF01217.20 ETO06796.1 - 2.8e-52 176.4 2.9 3.1e-52 176.3 2.9 1.0 1 0 0 1 1 1 1 Clathrin adaptor complex small chain 7tm_3 PF00003.22 ETO06797.1 - 2e-30 106.3 29.8 2e-30 106.3 29.8 2.3 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR MFS_1 PF07690.16 ETO06799.1 - 4.3e-10 39.0 15.5 6.8e-10 38.4 15.5 1.3 1 0 0 1 1 1 1 Major Facilitator Superfamily MtN3_slv PF03083.16 ETO06799.1 - 0.076 13.1 1.1 3.7 7.7 0.0 2.6 2 1 0 2 2 2 0 Sugar efflux transporter for intercellular exchange WD40 PF00400.32 ETO06800.1 - 1.2e-24 86.1 23.3 9.7e-08 32.6 1.3 5.4 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO06800.1 - 4.3e-08 32.3 0.4 0.15 10.6 0.0 4.0 3 1 1 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06800.1 - 0.00019 21.7 0.1 0.86 9.9 0.0 4.2 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ricin_B_lectin PF00652.22 ETO06800.1 - 1.1 9.5 4.5 0.82 9.9 1.7 2.0 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain UCH PF00443.29 ETO06801.1 - 2.5e-43 148.4 10.6 1.2e-28 100.3 0.2 4.3 4 1 0 4 4 4 2 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ETO06801.1 - 6.1e-15 55.6 0.0 6.1e-15 55.6 0.0 4.7 4 1 0 4 4 4 1 DUSP domain UCH_1 PF13423.6 ETO06801.1 - 5.5e-08 32.8 27.7 2.6e-05 24.0 0.4 4.2 3 2 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase zf-C2H2_4 PF13894.6 ETO06802.1 - 0.0003 21.4 30.3 0.037 14.9 2.5 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger zf-PHD-like PF15446.6 ETO06802.1 - 0.0023 17.6 1.8 0.0023 17.6 1.8 2.5 1 1 0 2 2 2 1 PHD/FYVE-zinc-finger like domain zf-C2H2_11 PF16622.5 ETO06802.1 - 0.0054 16.5 1.9 0.0054 16.5 1.9 3.4 4 0 0 4 4 4 1 zinc-finger C2H2-type zf-Di19 PF05605.12 ETO06802.1 - 0.0078 16.5 20.1 0.26 11.6 7.9 3.0 2 1 0 2 2 2 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 ETO06802.1 - 0.013 15.9 1.6 0.013 15.9 1.6 4.5 2 2 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ETO06802.1 - 0.034 14.8 4.2 0.034 14.8 4.2 3.3 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats RRN9 PF10680.9 ETO06802.1 - 0.046 14.0 0.6 0.046 14.0 0.6 2.9 3 0 0 3 3 3 0 RNA polymerase I specific transcription initiation factor Lar_restr_allev PF14354.6 ETO06802.1 - 0.051 14.0 3.2 3.2 8.2 0.2 2.7 2 0 0 2 2 2 0 Restriction alleviation protein Lar DUF1764 PF08576.10 ETO06802.1 - 0.56 11.1 24.2 0.085 13.8 17.5 2.6 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) Zn-ribbon_8 PF09723.10 ETO06802.1 - 0.88 9.7 9.7 4.3 7.5 0.3 3.6 4 0 0 4 4 4 0 Zinc ribbon domain Zn_Tnp_IS1595 PF12760.7 ETO06802.1 - 0.88 9.6 8.4 0.53 10.3 4.1 2.3 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-C2H2 PF00096.26 ETO06802.1 - 1.3 9.6 32.1 0.11 13.1 3.0 4.5 4 1 0 4 4 3 0 Zinc finger, C2H2 type Zn_ribbon_SprT PF17283.2 ETO06802.1 - 1.3 8.9 6.0 0.5 10.3 2.7 2.0 2 0 0 2 2 2 0 SprT-like zinc ribbon domain DUF2256 PF10013.9 ETO06802.1 - 1.6 8.9 0.0 1.6 8.9 0.0 3.7 3 1 1 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2256) DZR PF12773.7 ETO06802.1 - 3.7 7.7 8.4 0.84 9.7 0.9 2.7 2 1 0 2 2 2 0 Double zinc ribbon zf-C2H2_9 PF16293.5 ETO06802.1 - 7.9 6.4 10.7 18 5.3 0.2 4.1 2 2 2 4 4 4 0 C2H2 type zinc-finger (1 copy) EF-hand_1 PF00036.32 ETO06803.1 - 0.00025 20.4 0.0 0.00064 19.1 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ETO06803.1 - 0.00078 18.8 0.2 0.0018 17.6 0.2 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO06803.1 - 0.027 14.9 0.0 0.059 13.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO06803.1 - 0.079 12.9 1.1 0.13 12.3 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain DUF3439 PF11921.8 ETO06804.1 - 1.3 9.0 20.8 0.75 9.8 10.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) ORC_WH_C PF18137.1 ETO06804.1 - 1.4 9.0 6.2 3.8 7.6 0.2 3.3 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal DUF1840 PF08895.11 ETO06804.1 - 1.4 9.3 5.6 14 6.0 0.5 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Lipase PF00151.19 ETO06805.1 - 0.024 13.9 2.5 0.028 13.7 2.5 1.1 1 0 0 1 1 1 0 Lipase Sec62 PF03839.16 ETO06805.1 - 0.37 10.2 7.6 0.46 10.0 7.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO06805.1 - 0.64 8.7 3.3 0.71 8.6 3.3 1.1 1 0 0 1 1 1 0 Presenilin U-box PF04564.15 ETO06806.1 - 1.7e-09 37.7 0.1 1.7e-09 37.7 0.1 2.3 2 0 0 2 2 2 1 U-box domain Kelch_6 PF13964.6 ETO06806.1 - 0.044 14.1 0.1 1.1 9.7 0.1 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO06806.1 - 0.044 13.4 0.1 0.58 9.8 0.0 2.8 4 0 0 4 4 4 0 Kelch motif SlyX PF04102.12 ETO06806.1 - 0.22 12.1 6.7 0.3 11.7 0.3 3.4 3 0 0 3 3 3 0 SlyX FliT PF05400.13 ETO06806.1 - 1.1 10.1 4.5 0.58 11.0 0.2 2.8 2 1 1 3 3 3 0 Flagellar protein FliT TFIIE_alpha PF02002.17 ETO06807.1 - 0.016 15.0 0.2 0.049 13.5 0.0 1.9 2 0 0 2 2 2 0 TFIIE alpha subunit PPP4R2 PF09184.11 ETO06808.1 - 0.043 13.4 40.7 0.06 12.9 40.7 1.2 1 0 0 1 1 1 0 PPP4R2 Rhabdo_ncap PF00945.18 ETO06808.1 - 0.061 12.2 8.0 0.096 11.6 8.0 1.3 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein Nucleo_P87 PF07267.11 ETO06808.1 - 2.1 7.1 23.5 2.6 6.8 23.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MethyTransf_Reg PF10119.9 ETO06811.1 - 0.46 11.2 3.8 26 5.6 0.1 4.5 5 0 0 5 5 5 0 Predicted methyltransferase regulatory domain zf-UBR PF02207.20 ETO06812.1 - 1.4e-08 34.8 11.0 1.4e-08 34.8 11.0 2.1 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) WD40 PF00400.32 ETO06813.1 - 1.2e-05 25.9 1.1 1.5 9.8 0.1 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat Actin PF00022.19 ETO06816.1 - 3e-119 398.3 0.0 9.5e-119 396.6 0.0 1.6 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO06816.1 - 0.03 13.2 0.0 0.053 12.3 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein WD40 PF00400.32 ETO06817.1 - 3.2e-60 198.7 22.9 2.5e-10 40.8 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06817.1 - 8.1e-26 90.2 5.8 2.8e-05 24.3 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06817.1 - 2.4e-14 53.4 2.6 0.00076 18.9 0.0 3.6 2 1 2 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO06817.1 - 7.9e-14 51.3 1.1 0.11 11.4 0.0 6.0 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO06817.1 - 7.9e-11 41.3 6.9 0.0095 14.6 0.0 5.3 1 1 5 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO06817.1 - 4.5e-07 28.7 3.1 0.0003 19.5 0.2 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO06817.1 - 3e-06 26.9 0.1 17 5.6 0.0 5.3 5 0 0 5 5 5 0 PQQ enzyme repeat PQQ_2 PF13360.6 ETO06817.1 - 2.1e-05 24.2 5.9 0.68 9.5 0.5 3.1 1 1 1 3 3 3 3 PQQ-like domain Nucleoporin_N PF08801.11 ETO06817.1 - 5.9e-05 22.0 11.9 0.34 9.6 0.0 4.2 1 1 3 4 4 4 3 Nup133 N terminal like DUF5570 PF17731.1 ETO06817.1 - 0.0015 18.6 4.1 0.65 10.1 0.3 4.4 1 1 4 5 5 5 1 Family of unknown function (DUF5570) TolB_N PF04052.13 ETO06817.1 - 0.0052 16.9 0.1 53 4.1 0.0 5.1 6 0 0 6 6 6 0 TolB amino-terminal domain Biotin_lipoyl_2 PF13533.6 ETO06817.1 - 0.0069 16.2 0.1 0.68 9.8 0.0 2.8 2 0 0 2 2 2 1 Biotin-lipoyl like FlaE PF07559.14 ETO06817.1 - 0.0076 16.8 0.4 0.014 16.0 0.4 1.7 1 1 0 1 1 1 1 Flagellar basal body protein FlaE BBS2_Mid PF14783.6 ETO06817.1 - 0.0076 16.3 8.1 9.8 6.3 0.1 5.2 2 2 2 4 4 4 1 Ciliary BBSome complex subunit 2, middle region PALB2_WD40 PF16756.5 ETO06817.1 - 0.012 14.5 3.4 0.65 8.9 0.2 3.4 1 1 3 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO06817.1 - 0.043 13.8 11.7 34 4.5 0.0 6.1 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat NHL PF01436.21 ETO06817.1 - 0.2 11.8 0.6 16 5.8 0.0 3.3 4 0 0 4 4 3 0 NHL repeat DUF2963 PF11178.8 ETO06817.1 - 0.28 10.9 10.1 2.3 8.0 0.0 5.4 4 2 1 5 5 5 0 Protein of unknown function (DUF2963) Exo_endo_phos_2 PF14529.6 ETO06818.1 - 2.7e-16 59.5 1.1 9.5e-16 57.7 1.1 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RVT_1 PF00078.27 ETO06818.1 - 2.1e-09 37.2 0.1 4.9e-09 36.0 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 ETO06818.1 - 0.0038 16.8 0.3 0.0076 15.8 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family POLO_box PF00659.18 ETO06819.1 - 1.1e-35 121.6 8.6 3.5e-21 75.1 0.2 2.4 2 0 0 2 2 2 2 POLO box duplicated region CENP-B_dimeris PF09026.10 ETO06819.1 - 0.026 14.9 0.3 0.05 14.0 0.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PAXIP1_C PF15364.6 ETO06819.1 - 0.54 10.6 9.6 0.066 13.5 5.0 1.8 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein DUF2385 PF09539.10 ETO06819.1 - 0.57 10.7 4.8 6.2 7.4 1.5 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2385) Atrophin-1 PF03154.15 ETO06819.1 - 3.7 5.7 6.8 5.3 5.2 6.8 1.2 1 0 0 1 1 1 0 Atrophin-1 family Mog1 PF04603.12 ETO06819.1 - 5.3 7.4 7.7 3.3 8.1 4.7 2.2 2 1 0 2 2 2 0 Ran-interacting Mog1 protein GDC-P PF02347.16 ETO06820.1 - 6.9e-64 216.3 0.1 7.5e-64 216.1 0.1 1.0 1 0 0 1 1 1 1 Glycine cleavage system P-protein Med11 PF10280.9 ETO06821.1 - 0.0035 17.8 3.0 12 6.3 0.0 4.1 3 2 1 4 4 4 3 Mediator complex protein DUF2935 PF11155.8 ETO06821.1 - 4.9 7.5 8.3 13 6.1 1.8 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) ERAP1_C PF11838.8 ETO06822.1 - 2.9e-10 40.2 0.1 6.9e-10 39.0 0.1 1.5 1 1 0 1 1 1 1 ERAP1-like C-terminal domain DNA_pol_phi PF04931.13 ETO06823.1 - 0.0018 16.5 21.0 0.0018 16.5 21.0 1.7 2 0 0 2 2 2 1 DNA polymerase phi PUMA PF15826.5 ETO06823.1 - 0.0027 17.9 1.6 0.0041 17.3 1.6 1.2 1 0 0 1 1 1 1 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis DUF2722 PF10846.8 ETO06823.1 - 0.26 10.2 28.6 0.65 8.9 16.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) CPSF100_C PF13299.6 ETO06823.1 - 0.53 10.4 10.4 2.1 8.5 0.7 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 ETO06823.1 - 1.7 7.3 9.8 0.6 8.8 2.5 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 PTPRCAP PF15713.5 ETO06823.1 - 3.3 8.0 14.2 4.4 7.6 9.2 2.4 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated PH PF00169.29 ETO06825.1 - 2e-05 25.0 7.5 0.00089 19.7 0.1 3.5 3 0 0 3 3 3 2 PH domain SID-1_RNA_chan PF13965.6 ETO06826.1 - 1.8 6.9 4.1 2.6 6.4 4.1 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Mito_carr PF00153.27 ETO06828.1 - 1e-15 57.4 0.2 1.7e-06 27.9 0.0 2.3 2 1 0 2 2 2 2 Mitochondrial carrier protein TraK PF06586.11 ETO06830.1 - 0.009 15.7 1.1 0.012 15.3 1.1 1.2 1 0 0 1 1 1 1 TraK protein Hydin_ADK PF17213.3 ETO06830.1 - 0.075 13.3 2.5 0.12 12.7 2.5 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain DUF3439 PF11921.8 ETO06830.1 - 0.44 10.5 7.8 0.88 9.5 7.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO06830.1 - 2.7 6.1 11.7 3.6 5.7 11.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF929 PF06053.11 ETO06831.1 - 0.12 11.7 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) TM_helix PF05552.12 ETO06832.1 - 0.6 10.1 5.7 1.5 8.9 5.7 1.7 1 0 0 1 1 1 0 Conserved TM helix Vpu PF00558.19 ETO06832.1 - 1.9 8.3 4.0 0.5 10.2 0.1 2.1 2 0 0 2 2 2 0 Vpu protein Chitin_synth_2 PF03142.15 ETO06832.1 - 2 6.9 8.5 3.4 6.2 8.5 1.2 1 0 0 1 1 1 0 Chitin synthase 60KD_IMP PF02096.20 ETO06832.1 - 6.5 6.6 8.4 3.6 7.5 0.0 3.1 2 1 0 2 2 2 0 60Kd inner membrane protein Exo_endo_phos PF03372.23 ETO06833.1 - 0.0064 16.0 0.0 0.015 14.8 0.0 1.6 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family TruB_C_2 PF16198.5 ETO06834.1 - 0.22 11.7 0.3 0.58 10.3 0.3 1.8 1 1 0 1 1 1 0 tRNA pseudouridylate synthase B C-terminal domain Inhibitor_I34 PF10466.9 ETO06834.1 - 2.2 8.9 5.7 0.51 11.0 1.3 2.2 2 0 0 2 2 2 0 Saccharopepsin inhibitor I34 TPR_11 PF13414.6 ETO06835.1 - 1.6e-19 69.3 21.0 7.8e-05 22.3 0.1 4.2 3 1 1 4 4 4 4 TPR repeat TPR_17 PF13431.6 ETO06835.1 - 2.6e-13 49.3 21.7 0.00067 19.9 1.6 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO06835.1 - 8.6e-13 48.0 4.7 0.017 15.9 0.3 4.2 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06835.1 - 1e-11 44.0 24.9 0.0046 17.0 0.4 5.5 4 2 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06835.1 - 2.4e-11 42.9 14.7 0.0017 18.4 1.7 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06835.1 - 7.1e-11 41.4 25.3 0.00085 19.0 3.2 5.8 3 2 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO06835.1 - 5.6e-09 36.4 11.4 0.0036 17.8 1.7 3.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO06835.1 - 3.7e-08 33.5 29.8 4.5e-05 23.7 5.7 3.4 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO06835.1 - 6e-07 30.0 15.1 0.00062 20.4 2.0 3.8 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_9 PF13371.6 ETO06835.1 - 2.2e-05 24.5 2.4 0.00066 19.8 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO06835.1 - 0.00024 21.5 6.4 13 6.7 0.2 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat eIF-3c_N PF05470.12 ETO06835.1 - 0.019 13.3 3.1 0.026 12.9 3.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus FAT PF02259.23 ETO06835.1 - 0.021 14.1 5.5 0.028 13.6 2.2 2.1 1 1 1 2 2 2 0 FAT domain TPR_7 PF13176.6 ETO06835.1 - 0.029 14.4 8.1 9.5 6.5 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO06835.1 - 0.033 14.3 5.8 0.22 11.6 0.1 3.3 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Cor1 PF04803.12 ETO06835.1 - 0.12 12.6 0.2 0.18 12.0 0.2 1.4 1 0 0 1 1 1 0 Cor1/Xlr/Xmr conserved region Uds1 PF15456.6 ETO06836.1 - 0.00014 22.0 4.2 0.00014 22.0 4.2 1.8 2 0 0 2 2 2 1 Up-regulated During Septation PBP1_TM PF14812.6 ETO06836.1 - 0.0024 18.2 7.2 0.0024 18.2 7.2 1.9 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ETO06836.1 - 0.046 11.8 6.5 0.054 11.6 6.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi HSP90 PF00183.18 ETO06836.1 - 0.27 10.1 8.5 0.34 9.7 8.5 1.2 1 0 0 1 1 1 0 Hsp90 protein DUF2457 PF10446.9 ETO06836.1 - 0.76 8.8 20.9 0.061 12.5 14.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) FAM176 PF14851.6 ETO06836.1 - 1.2 8.8 8.7 0.4 10.3 5.6 1.8 2 0 0 2 2 2 0 FAM176 family Pes-10 PF07149.11 ETO06836.1 - 1.5 7.8 9.8 2.2 7.2 9.8 1.1 1 0 0 1 1 1 0 Pes-10 Cwf_Cwc_15 PF04889.12 ETO06836.1 - 1.6 8.4 20.0 0.57 9.9 16.2 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Connexin PF00029.19 ETO06836.1 - 2.6 7.7 4.9 17 5.1 3.9 2.0 2 0 0 2 2 2 0 Connexin Secretin_N_2 PF07655.13 ETO06836.1 - 4.8 7.8 9.1 8.1 7.1 1.1 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain TraF_2 PF13729.6 ETO06838.1 - 0.0003 20.2 4.9 0.12 11.8 0.3 2.2 2 0 0 2 2 2 2 F plasmid transfer operon, TraF, protein XPC-binding PF09280.11 ETO06838.1 - 0.0054 16.4 7.8 2.6 7.9 3.7 3.7 3 1 1 4 4 3 1 XPC-binding domain Filament PF00038.21 ETO06838.1 - 0.0091 15.6 33.0 0.013 15.1 7.5 2.2 1 1 1 2 2 2 1 Intermediate filament protein CR6_interact PF10147.9 ETO06838.1 - 0.014 15.1 8.9 0.014 15.1 8.9 2.1 2 0 0 2 2 2 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Fib_alpha PF08702.10 ETO06838.1 - 0.016 15.4 16.1 0.016 15.4 16.1 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family Matrilin_ccoil PF10393.9 ETO06838.1 - 0.016 15.1 1.1 0.016 15.1 1.1 4.1 4 1 0 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin RdDM_RDM1 PF09187.10 ETO06838.1 - 0.036 14.1 0.3 0.24 11.5 0.3 2.2 1 1 0 1 1 1 0 RNA-directed DNA methylation 1 Pex19 PF04614.12 ETO06838.1 - 0.056 13.2 32.4 0.29 10.9 5.8 2.1 1 1 1 2 2 2 0 Pex19 protein family Baculo_PEP_C PF04513.12 ETO06838.1 - 0.24 11.4 28.5 4 7.5 12.2 3.4 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4407 PF14362.6 ETO06838.1 - 0.26 10.6 24.3 0.69 9.2 12.4 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) TetR PF13972.6 ETO06838.1 - 0.27 10.9 9.4 0.052 13.3 2.4 2.9 2 2 1 3 3 3 0 Bacterial transcriptional repressor Occludin_ELL PF07303.13 ETO06838.1 - 0.29 11.9 21.5 0.9 10.3 1.2 3.8 1 1 3 4 4 4 0 Occludin homology domain DUF445 PF04286.12 ETO06838.1 - 0.38 10.5 27.6 0.12 12.2 15.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF445) HH_signal PF01085.18 ETO06838.1 - 0.38 10.4 3.2 0.3 10.7 1.5 1.8 1 1 0 1 1 1 0 Hedgehog amino-terminal signalling domain FUSC PF04632.12 ETO06838.1 - 0.38 9.2 4.3 4.6 5.7 4.3 2.0 1 1 0 1 1 1 0 Fusaric acid resistance protein family FTCD_C PF04961.12 ETO06838.1 - 0.48 10.2 13.1 0.22 11.3 6.4 2.7 1 1 2 3 3 3 0 Formiminotransferase-cyclodeaminase DUF883 PF05957.13 ETO06838.1 - 0.67 10.6 14.3 13 6.5 2.0 3.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) PIN_8 PF18476.1 ETO06838.1 - 0.73 9.6 29.3 0.14 12.0 7.0 3.0 1 1 2 3 3 3 0 PIN like domain WXG100 PF06013.12 ETO06838.1 - 0.75 10.1 20.6 0.52 10.6 2.3 4.6 2 2 1 3 3 3 0 Proteins of 100 residues with WXG Jnk-SapK_ap_N PF09744.9 ETO06838.1 - 1.1 9.5 33.5 0.13 12.5 15.5 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF3584 PF12128.8 ETO06838.1 - 1.1 6.7 30.5 3.5 5.0 30.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Syntaxin-6_N PF09177.11 ETO06838.1 - 1.2 9.7 24.9 0.28 11.7 3.3 3.6 1 1 2 3 3 3 0 Syntaxin 6, N-terminal DUF885 PF05960.11 ETO06838.1 - 1.5 8.4 11.2 5.5 6.5 9.4 1.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF885) PilJ PF13675.6 ETO06838.1 - 1.6 8.8 12.6 0.72 9.9 3.1 2.7 1 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Alpha-E PF04168.12 ETO06838.1 - 1.9 8.2 12.2 1.4 8.7 2.1 2.2 2 0 0 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. ISG65-75 PF11727.8 ETO06838.1 - 2 7.6 17.6 0.35 10.1 7.9 2.1 2 0 0 2 2 2 0 Invariant surface glycoprotein UCH PF00443.29 ETO06838.1 - 2.1 7.8 22.1 0.039 13.4 5.6 2.1 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase COMM_domain PF07258.14 ETO06838.1 - 2.6 8.2 14.3 9.3 6.5 3.3 3.2 2 1 0 2 2 2 0 COMM domain CHDCT2 PF08074.11 ETO06838.1 - 3.2 7.9 21.8 0.45 10.7 6.9 3.0 1 1 2 3 3 3 0 CHDCT2 (NUC038) domain HSBP1 PF06825.12 ETO06838.1 - 3.2 7.7 20.1 0.42 10.5 7.4 4.7 5 1 0 5 5 3 0 Heat shock factor binding protein 1 DUF724 PF05266.14 ETO06838.1 - 3.4 7.5 30.5 2.3 8.0 12.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 ETO06838.1 - 3.6 7.6 28.7 0.32 11.0 9.4 3.4 1 1 1 2 2 1 0 Protein of unknown function (DUF1664) YabA PF06156.13 ETO06838.1 - 4.8 7.9 29.6 0.43 11.2 3.7 3.7 1 1 2 3 3 3 0 Initiation control protein YabA MRP-L47 PF06984.13 ETO06838.1 - 5.3 7.2 11.5 0.39 10.9 0.2 3.4 1 1 2 3 3 3 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) DUF5344 PF17279.2 ETO06838.1 - 5.3 7.7 27.2 6.1 7.5 1.5 4.0 1 1 4 5 5 4 0 Family of unknown function (DUF5344) NusB PF01029.18 ETO06838.1 - 8 6.7 15.8 0.72 10.1 5.4 3.1 1 1 1 2 2 2 0 NusB family Macoilin PF09726.9 ETO06838.1 - 8.1 4.9 28.7 11 4.4 28.7 1.2 1 0 0 1 1 1 0 Macoilin family DUF3492 PF11997.8 ETO06838.1 - 9.2 5.9 12.1 1.6 8.4 4.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3492) GUCT PF08152.12 ETO06838.1 - 9.6 6.6 11.2 2.9 8.2 1.6 3.3 1 1 3 4 4 4 0 GUCT (NUC152) domain COG5 PF10392.9 ETO06838.1 - 9.9 6.4 32.5 0.12 12.5 9.0 3.2 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DUF5409 PF17421.2 ETO06839.1 - 0.04 14.6 0.6 0.084 13.6 0.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5409) PBP1_TM PF14812.6 ETO06839.1 - 0.16 12.3 8.4 0.33 11.3 8.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO06839.1 - 0.4 9.9 7.3 0.57 9.5 7.3 1.2 1 0 0 1 1 1 0 NOA36 protein AAA_11 PF13086.6 ETO06839.1 - 0.48 10.2 4.0 0.83 9.4 4.0 1.3 1 0 0 1 1 1 0 AAA domain RNase_H2_suC PF08615.11 ETO06839.1 - 0.62 10.2 3.8 7.5 6.7 1.2 2.3 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) FAM176 PF14851.6 ETO06839.1 - 3.3 7.4 8.6 1.3 8.7 4.9 2.0 2 0 0 2 2 2 0 FAM176 family Kinesin PF00225.23 ETO06840.1 - 1.8e-07 30.4 0.1 2.1e-07 30.2 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO06840.1 - 0.00022 21.2 0.3 0.0003 20.8 0.3 1.1 1 0 0 1 1 1 1 Microtubule binding Rib PF08428.10 ETO06840.1 - 0.15 12.0 0.8 0.2 11.6 0.0 1.6 2 0 0 2 2 2 0 Rib/alpha-like repeat CENP-B_dimeris PF09026.10 ETO06842.1 - 0.0049 17.2 0.4 0.0049 17.2 0.4 2.7 2 0 0 2 2 2 1 Centromere protein B dimerisation domain RE_Bpu10I PF09549.10 ETO06843.1 - 0.026 14.1 0.0 0.045 13.3 0.0 1.3 1 0 0 1 1 1 0 Bpu10I restriction endonuclease SelP_N PF04592.14 ETO06843.1 - 0.76 9.1 19.8 1.2 8.5 19.8 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region PNP_UDP_1 PF01048.20 ETO06844.1 - 1.1e-11 44.4 0.0 2.1e-11 43.6 0.0 1.4 2 0 0 2 2 2 1 Phosphorylase superfamily LETM1 PF07766.13 ETO06844.1 - 0.03 13.7 3.3 0.061 12.7 3.3 1.4 1 0 0 1 1 1 0 LETM1-like protein Nipped-B_C PF12830.7 ETO06844.1 - 0.064 13.2 0.8 0.11 12.4 0.8 1.4 1 0 0 1 1 1 0 Sister chromatid cohesion C-terminus FluMu_N PF17891.1 ETO06844.1 - 0.24 11.2 0.5 1.6 8.6 0.5 2.1 2 0 0 2 2 2 0 Mu-like prophage FluMu N-terminal domain SMAP PF15477.6 ETO06844.1 - 0.62 11.1 3.9 1.6 9.7 3.9 1.7 1 0 0 1 1 1 0 Small acidic protein family Proteasome PF00227.26 ETO06847.1 - 1e-21 77.3 0.5 1.7e-19 70.0 0.5 2.4 1 1 0 1 1 1 1 Proteasome subunit Mesd PF10185.9 ETO06847.1 - 0.0056 16.6 2.1 0.01 15.8 2.1 1.4 1 0 0 1 1 1 1 Chaperone for wingless signalling and trafficking of LDL receptor Ras PF00071.22 ETO06848.1 - 6.8e-20 71.3 0.3 8.7e-20 70.9 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO06848.1 - 0.026 14.7 0.1 0.096 12.9 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Syntaxin-18_N PF10496.9 ETO06849.1 - 0.14 12.4 2.4 2.2 8.6 0.1 2.5 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Speriolin_C PF15059.6 ETO06850.1 - 0.03 14.4 0.0 0.084 13.0 0.0 1.7 2 0 0 2 2 2 0 Speriolin C-terminus Borrelia_P83 PF05262.11 ETO06851.1 - 0.16 10.4 37.3 0.0039 15.7 27.4 2.1 2 0 0 2 2 2 0 Borrelia P83/100 protein Exo_endo_phos PF03372.23 ETO06852.1 - 9.3e-10 38.4 0.0 1.1e-07 31.7 0.0 2.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4315 PF14193.6 ETO06852.1 - 0.98 9.5 5.1 3.5 7.7 5.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4315) RVT_N PF13655.6 ETO06853.1 - 0.03 14.6 0.8 0.048 13.9 0.8 1.4 1 0 0 1 1 1 0 N-terminal domain of reverse transcriptase Glyco_transf_88 PF16849.5 ETO06854.1 - 0.02 13.8 0.3 0.022 13.7 0.3 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 88 Asparaginase PF00710.20 ETO06855.1 - 6.8e-53 179.1 0.0 3.3e-45 154.0 0.0 2.6 3 0 0 3 3 3 2 Asparaginase, N-terminal Asparaginase_C PF17763.1 ETO06855.1 - 1.2e-07 31.9 0.0 3e-07 30.7 0.0 1.7 1 0 0 1 1 1 1 Glutaminase/Asparaginase C-terminal domain WD40 PF00400.32 ETO06857.1 - 3.7e-63 207.9 18.5 8.3e-10 39.1 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06857.1 - 8.3e-21 74.1 6.3 0.017 15.4 0.1 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO06857.1 - 1.3e-15 57.8 2.2 1.7e-06 28.1 0.2 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO06857.1 - 3.1e-13 49.4 1.9 0.031 13.2 0.1 5.9 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO06857.1 - 3.1e-11 43.2 1.2 0.0084 15.5 0.0 3.9 3 1 1 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO06857.1 - 3.6e-11 42.4 7.5 0.16 10.6 0.0 6.7 2 2 5 7 7 7 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO06857.1 - 0.00022 21.1 4.3 0.97 9.5 0.2 5.3 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Me-amine-dh_H PF06433.11 ETO06857.1 - 0.004 16.1 0.1 1.9 7.3 0.0 2.9 3 0 0 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO06857.1 - 0.0063 15.1 0.7 4.8 5.6 0.1 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO06857.1 - 0.007 15.2 0.2 3.4 6.3 0.0 3.5 1 1 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nucleoporin_N PF08801.11 ETO06857.1 - 0.0097 14.7 9.4 0.7 8.6 0.1 4.6 1 1 4 5 5 5 3 Nup133 N terminal like Big_7 PF17957.1 ETO06857.1 - 0.011 16.4 0.6 14 6.5 0.1 3.3 3 0 0 3 3 3 0 Bacterial Ig domain DUF5474 PF17568.2 ETO06857.1 - 0.012 15.6 0.4 3.6 7.7 0.0 3.7 4 0 0 4 4 3 0 Family of unknown function (DUF5474) Resistin PF06954.11 ETO06857.1 - 0.035 14.6 0.3 14 6.3 0.0 3.5 2 1 1 3 3 3 0 Resistin DUF1513 PF07433.11 ETO06857.1 - 0.18 10.9 0.2 2.4 7.2 0.1 2.7 2 2 1 3 3 3 0 Protein of unknown function (DUF1513) PALB2_WD40 PF16756.5 ETO06857.1 - 0.37 9.7 8.2 0.38 9.6 0.1 4.2 1 1 4 5 5 5 0 Partner and localizer of BRCA2 WD40 domain AzlD PF05437.12 ETO06858.1 - 0.027 14.7 2.5 0.077 13.2 2.5 1.8 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) DUF373 PF04123.13 ETO06858.1 - 0.59 9.5 3.5 1 8.7 3.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF2070 PF09843.9 ETO06858.1 - 3.5 5.8 8.7 5.8 5.1 8.7 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) NACHT PF05729.12 ETO06859.1 - 5.1e-08 33.0 0.0 8.2e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO06859.1 - 0.00037 19.7 0.3 0.00037 19.7 0.3 2.4 1 1 2 3 3 3 1 NB-ARC domain AAA_16 PF13191.6 ETO06859.1 - 0.00058 20.3 0.0 0.001 19.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO06859.1 - 0.0056 17.0 4.4 0.21 12.0 0.0 3.1 1 1 2 3 3 3 1 RNA helicase AAA_22 PF13401.6 ETO06859.1 - 0.0067 16.7 0.0 0.016 15.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETO06859.1 - 0.015 14.7 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO06859.1 - 0.039 13.7 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 ETO06859.1 - 0.064 12.8 0.1 0.48 9.9 0.0 2.1 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_30 PF13604.6 ETO06859.1 - 0.083 12.6 0.1 0.26 11.0 0.0 1.7 1 1 1 2 2 2 0 AAA domain Torsin PF06309.11 ETO06859.1 - 0.11 12.6 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 Torsin SPT16 PF08644.11 ETO06859.1 - 0.19 11.9 5.0 7.1 6.8 0.0 2.2 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) GIY-YIG PF01541.24 ETO06859.1 - 2.5 8.5 7.4 1.8 8.9 3.6 2.4 2 0 0 2 2 2 0 GIY-YIG catalytic domain HEAT PF02985.22 ETO06860.1 - 1.7e-08 34.0 6.9 0.47 10.9 0.0 7.3 8 0 0 8 8 8 3 HEAT repeat HEAT_2 PF13646.6 ETO06860.1 - 1.3e-07 31.9 0.0 0.11 12.9 0.0 5.0 3 1 2 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 ETO06860.1 - 0.00038 20.9 0.0 16 6.1 0.0 5.7 7 0 0 7 7 7 1 HEAT-like repeat UME PF08064.13 ETO06860.1 - 0.0012 18.7 2.0 0.0049 16.7 0.1 3.0 3 0 0 3 3 3 1 UME (NUC010) domain Utp13 PF08625.11 ETO06860.1 - 0.0021 18.0 9.3 0.062 13.2 0.4 4.5 3 2 1 4 4 4 1 Utp13 specific WD40 associated domain Vac14_Fab1_bd PF12755.7 ETO06860.1 - 0.0037 17.8 16.7 0.6 10.7 0.5 5.9 4 2 1 5 5 5 2 Vacuolar 14 Fab1-binding region DUF627 PF04781.12 ETO06860.1 - 0.076 13.0 0.0 0.34 10.9 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF627) NLRC4_HD2 PF17776.1 ETO06860.1 - 0.42 11.2 0.0 0.42 11.2 0.0 4.7 4 2 0 5 5 5 0 NLRC4 helical domain HD2 CRM1_C PF08767.11 ETO06861.1 - 1.1e-05 24.8 0.3 2.4e-05 23.6 0.3 1.7 1 1 0 1 1 1 1 CRM1 C terminal Rh5 PF18515.1 ETO06861.1 - 0.018 14.4 1.1 0.033 13.5 0.1 1.7 2 0 0 2 2 2 0 Rh5 coiled-coil domain TRCF PF03461.15 ETO06861.1 - 0.023 15.1 0.0 10 6.6 0.0 2.3 2 0 0 2 2 2 0 TRCF domain HEAT PF02985.22 ETO06861.1 - 0.025 14.8 1.0 13 6.4 0.0 3.9 5 0 0 5 5 5 0 HEAT repeat RPAP3_C PF13877.6 ETO06861.1 - 0.028 15.0 0.2 0.27 11.8 0.1 2.6 1 1 1 2 2 2 0 Potential Monad-binding region of RPAP3 DUF507 PF04368.13 ETO06861.1 - 0.069 13.1 0.3 0.44 10.4 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF507) TAF6_C PF07571.13 ETO06861.1 - 0.11 12.8 0.5 6.9 7.1 0.2 3.0 1 1 1 3 3 3 0 TAF6 C-terminal HEAT repeat domain TTRAP PF14203.6 ETO06861.1 - 0.32 11.0 2.0 2.5 8.1 0.0 2.8 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein HMD PF03201.16 ETO06862.1 - 0.14 12.4 0.3 0.32 11.2 0.3 1.6 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase UPRTase PF14681.6 ETO06864.1 - 4.7e-12 45.8 0.1 8.6e-11 41.7 0.0 2.1 2 0 0 2 2 2 1 Uracil phosphoribosyltransferase RPN2_C PF18004.1 ETO06864.1 - 7.9 6.4 12.6 14 5.6 12.6 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain ABC_membrane_2 PF06472.15 ETO06865.1 - 6.2e-40 137.3 1.6 8.3e-40 136.9 1.6 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 ABC_tran PF00005.27 ETO06865.1 - 5.8e-10 39.8 0.0 2.1e-09 38.0 0.0 2.0 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO06865.1 - 4.6e-06 26.7 0.0 1.1e-05 25.4 0.0 1.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ETO06865.1 - 0.0034 17.9 3.1 0.0039 17.7 0.0 2.3 3 0 0 3 3 3 1 AAA domain NACHT PF05729.12 ETO06865.1 - 0.0058 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain SMC_N PF02463.19 ETO06865.1 - 0.015 14.8 0.0 0.031 13.7 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 ETO06865.1 - 0.043 13.2 0.0 0.1 11.9 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_15 PF13175.6 ETO06865.1 - 0.048 13.4 2.4 0.11 12.2 0.4 2.3 2 1 0 2 2 2 0 AAA ATPase domain AAA PF00004.29 ETO06865.1 - 0.1 13.0 0.0 0.49 10.8 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ETO06865.1 - 0.12 12.2 0.0 0.3 10.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ETO06865.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain PGI PF00342.19 ETO06866.1 - 7.4e-138 460.2 0.0 1.5e-109 366.8 0.0 2.0 2 0 0 2 2 2 2 Phosphoglucose isomerase RVT_1 PF00078.27 ETO06867.1 - 5.9e-39 133.9 0.1 1.4e-38 132.6 0.1 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 ETO06867.1 - 2.1e-18 66.3 0.8 1.1e-17 64.0 0.8 2.3 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase zf-CCHC PF00098.23 ETO06867.1 - 0.01 15.9 12.4 0.46 10.7 2.7 2.7 2 0 0 2 2 2 0 Zinc knuckle Exo_endo_phos PF03372.23 ETO06867.1 - 0.013 15.0 0.0 0.013 15.0 0.0 1.9 2 1 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family PUB PF09409.10 ETO06868.1 - 0.0084 16.0 0.2 0.0084 16.0 0.2 3.2 3 0 0 3 3 3 1 PUB domain CD225 PF04505.12 ETO06870.1 - 9.4e-11 41.7 2.0 1.7e-10 40.9 2.0 1.4 1 0 0 1 1 1 1 Interferon-induced transmembrane protein DUF5337 PF17272.2 ETO06870.1 - 0.025 14.4 0.8 0.055 13.3 0.8 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5337) Wzz PF02706.15 ETO06870.1 - 0.058 13.7 0.1 0.15 12.3 0.1 1.7 1 0 0 1 1 1 0 Chain length determinant protein DUF3464 PF11947.8 ETO06870.1 - 0.7 9.6 5.0 16 5.3 0.0 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Egg_lysin PF01303.17 ETO06871.1 - 3.3 8.0 7.1 25 5.1 1.5 3.3 2 1 1 3 3 3 0 Egg lysin (Sperm-lysin) Tenui_NCP PF04876.12 ETO06872.1 - 0.083 12.5 0.0 0.14 11.7 0.0 1.3 1 0 0 1 1 1 0 Tenuivirus major non-capsid protein Aldo_ket_red PF00248.21 ETO06873.1 - 0.0014 17.9 0.5 0.066 12.4 0.1 2.2 1 1 1 2 2 2 2 Aldo/keto reductase family ADPRTs_Tse2 PF18648.1 ETO06875.1 - 0.04 14.0 0.4 7.1 6.7 0.1 2.2 1 1 1 2 2 2 0 Tse2 ADP-ribosyltransferase toxins Ras PF00071.22 ETO06877.1 - 7.7e-07 28.8 0.0 1.1e-06 28.4 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO06877.1 - 1.8e-06 28.1 0.0 3.1e-06 27.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase CLZ PF16526.5 ETO06877.1 - 0.017 15.5 1.1 0.035 14.4 1.1 1.5 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Ribosomal_S7e PF01251.18 ETO06878.1 - 3.4e-56 189.9 8.6 1.6e-46 158.4 3.6 3.4 2 1 0 2 2 2 2 Ribosomal protein S7e DUF4551 PF15087.6 ETO06878.1 - 3.5 6.4 12.4 4.9 5.9 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CDC45 PF02724.14 ETO06878.1 - 4.1 5.6 8.8 5.5 5.2 8.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO06878.1 - 6.2 5.5 10.8 11 4.7 10.8 1.4 1 0 0 1 1 1 0 Presenilin Inovirus_Gp2 PF11726.8 ETO06879.1 - 0.096 12.6 1.3 0.21 11.5 1.2 1.5 1 1 0 1 1 1 0 Inovirus Gp2 Neur_chan_memb PF02932.16 ETO06879.1 - 0.23 11.5 3.0 0.5 10.4 3.0 1.6 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region VWA_2 PF13519.6 ETO06880.1 - 0.0023 18.5 0.0 0.0064 17.1 0.0 1.8 1 0 0 1 1 1 1 von Willebrand factor type A domain Helicase_C PF00271.31 ETO06880.1 - 0.0062 16.9 0.3 0.043 14.2 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Trp_dioxygenase PF03301.13 ETO06880.1 - 0.011 15.1 0.0 0.027 13.8 0.0 1.6 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase WD40 PF00400.32 ETO06881.1 - 1.3e-43 146.1 19.6 8.7e-07 29.6 0.5 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06881.1 - 3.8e-13 49.6 3.4 0.73 10.2 0.0 6.4 5 2 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06881.1 - 1.2e-12 47.3 4.5 0.042 12.5 0.0 5.9 4 2 0 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06881.1 - 1.3e-06 28.0 8.7 0.021 14.2 0.7 5.2 1 1 3 5 5 5 3 WD40-like domain DUF1541 PF07563.11 ETO06881.1 - 0.066 13.1 0.3 61 3.6 0.1 3.9 4 0 0 4 4 4 0 Protein of unknown function (DUF1541) CX9C PF16860.5 ETO06882.1 - 0.00042 20.3 1.9 0.0015 18.5 1.9 2.0 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Latarcin PF10279.9 ETO06882.1 - 0.0044 17.4 0.0 0.25 11.8 0.0 3.6 1 1 0 1 1 1 1 Latarcin precursor CAP18_C PF12153.8 ETO06882.1 - 0.016 15.0 6.3 0.14 12.1 0.0 3.2 3 0 0 3 3 3 0 LPS binding domain of CAP18 (C terminal) GrpE PF01025.19 ETO06883.1 - 0.04 13.6 2.5 0.18 11.5 0.2 2.0 2 0 0 2 2 2 0 GrpE Med9 PF07544.13 ETO06884.1 - 0.76 9.9 7.1 0.47 10.6 3.7 2.5 2 1 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 T4_Rnl2_C PF18043.1 ETO06884.1 - 2.4 8.3 9.9 2.6 8.3 5.5 2.8 2 1 0 2 2 2 0 T4 RNA ligase 2 C-terminal WD40 PF00400.32 ETO06885.1 - 1.5e-41 139.6 26.9 6.3e-09 36.3 0.8 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06885.1 - 3.5e-14 52.9 0.5 0.029 14.7 0.0 5.5 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06885.1 - 8.6e-13 47.8 6.8 0.013 14.2 0.1 5.9 2 1 4 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06885.1 - 1.7e-06 27.6 6.6 0.29 10.4 0.4 4.8 2 2 3 5 5 5 4 WD40-like domain SH3_13 PF18335.1 ETO06885.1 - 0.1 12.5 1.8 3 7.7 0.3 3.5 3 1 1 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain OSK PF17182.4 ETO06885.1 - 0.17 11.1 2.1 0.74 9.0 0.5 2.1 1 1 1 2 2 2 0 OSK domain DASH_Ask1 PF08655.10 ETO06886.1 - 0.076 12.9 0.7 0.18 11.7 0.7 1.6 1 0 0 1 1 1 0 DASH complex subunit Ask1 Cg6151-P PF10233.9 ETO06886.1 - 0.48 10.7 4.3 0.45 10.8 1.9 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein CG6151-P WD40 PF00400.32 ETO06887.1 - 2e-13 50.5 10.1 6.2e-05 23.7 0.9 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO06887.1 - 0.00062 18.5 1.0 1.1 7.8 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06887.1 - 0.013 15.8 0.1 1.8 8.9 0.0 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF5530 PF17670.1 ETO06887.1 - 0.11 12.2 1.3 14 5.5 0.1 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5530) Toxin_28 PF08115.11 ETO06887.1 - 1.3 9.0 8.6 2.5 8.0 0.8 2.7 2 0 0 2 2 2 0 SFI toxin family Glyco_hydro_19 PF00182.19 ETO06889.1 - 0.059 13.3 0.0 0.088 12.7 0.0 1.2 1 0 0 1 1 1 0 Chitinase class I WD40 PF00400.32 ETO06890.1 - 1.7e-64 212.2 14.7 1.1e-10 41.9 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06890.1 - 2.3e-24 85.5 0.9 0.0048 17.2 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO06890.1 - 1.5e-20 73.4 2.3 0.024 13.6 0.0 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO06890.1 - 1.3e-09 38.2 1.7 0.29 11.2 0.1 5.8 1 1 5 6 6 6 2 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO06890.1 - 2.2e-07 30.5 1.0 0.0052 16.1 0.0 3.3 1 1 2 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO06890.1 - 7.1e-07 28.1 2.6 0.0011 17.5 0.2 3.3 1 1 3 4 4 4 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO06890.1 - 2.3e-05 23.5 1.9 0.031 13.2 0.1 3.7 1 1 0 2 2 2 2 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ETO06890.1 - 5.5e-05 22.0 6.7 2.4 6.7 0.0 5.0 1 1 4 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO06890.1 - 5.7e-05 22.9 3.4 3.6 7.7 0.2 5.6 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO06890.1 - 0.0021 17.2 0.1 0.15 11.1 0.0 2.6 1 1 0 2 2 2 1 VID27 C-terminal WD40-like domain DUF1258 PF06869.12 ETO06890.1 - 0.0024 17.4 0.5 0.084 12.3 0.1 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF1258) Proteasome_A_N PF10584.9 ETO06890.1 - 0.0043 16.7 6.5 9.3 6.0 0.1 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Frtz PF11768.8 ETO06890.1 - 0.0044 15.4 0.3 0.14 10.4 0.0 2.5 1 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz DPPIV_N PF00930.21 ETO06890.1 - 0.0065 15.3 0.0 6.9 5.3 0.0 3.7 1 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO06890.1 - 0.014 15.3 0.0 9.7 6.3 0.0 4.5 5 0 0 5 5 5 0 PQQ enzyme repeat DUF1854 PF08909.11 ETO06890.1 - 0.015 15.1 0.9 1.5 8.7 0.0 3.2 1 1 1 3 3 3 0 Domain of unknown function (DUF1854) Nucleoporin_N PF08801.11 ETO06890.1 - 0.021 13.6 5.1 1.4 7.6 1.1 3.8 1 1 3 4 4 4 0 Nup133 N terminal like DUF5449 PF17528.2 ETO06890.1 - 0.024 14.4 0.1 0.96 9.2 0.0 2.5 1 1 2 3 3 3 0 Family of unknown function (DUF5449) DUF4999 PF16390.5 ETO06890.1 - 0.054 13.7 2.1 16 5.8 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function HPS6 PF15702.5 ETO06890.1 - 0.18 9.7 0.0 1.9 6.4 0.0 2.5 1 1 2 3 3 3 0 Hermansky-Pudlak syndrome 6 protein Beta_elim_lyase PF01212.21 ETO06892.1 - 4.8e-70 236.1 0.0 6e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Beta-eliminating lyase PUFD PF16553.5 ETO06892.1 - 0.18 11.9 2.3 0.44 10.7 0.3 2.5 3 0 0 3 3 3 0 BCORL-PCGF1-binding domain Nudix_hydro PF18290.1 ETO06893.1 - 0.075 13.0 0.0 0.23 11.5 0.0 1.8 1 0 0 1 1 1 0 Nudix hydrolase domain Mpp10 PF04006.12 ETO06894.1 - 0.00036 19.1 24.9 0.00036 19.1 24.9 1.7 2 0 0 2 2 2 1 Mpp10 protein BSP_II PF05432.11 ETO06894.1 - 0.0026 17.5 20.3 0.0039 16.9 20.3 1.2 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SID-1_RNA_chan PF13965.6 ETO06894.1 - 0.019 13.4 2.3 0.024 13.1 2.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2052 PF09747.9 ETO06894.1 - 0.02 15.0 21.5 0.038 14.1 21.5 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO06894.1 - 0.13 10.5 22.1 0.19 10.0 22.1 1.1 1 0 0 1 1 1 0 CDC45-like protein V_ATPase_I PF01496.19 ETO06894.1 - 0.25 9.2 6.6 0.37 8.7 6.6 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CobT PF06213.12 ETO06894.1 - 0.25 10.7 18.0 0.41 10.0 18.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Peroxin-13_N PF04088.13 ETO06894.1 - 0.48 10.7 5.8 1.8 8.8 1.2 2.6 2 1 1 3 3 3 0 Peroxin 13, N-terminal region SLC12 PF03522.15 ETO06894.1 - 0.6 9.1 11.7 0.99 8.4 11.7 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF5308 PF17233.2 ETO06894.1 - 1.2 9.4 4.1 0.94 9.7 2.7 1.6 2 0 0 2 2 1 0 Family of unknown function (DUF5308) DUF913 PF06025.12 ETO06894.1 - 1.5 7.8 6.7 2.3 7.1 6.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 ETO06894.1 - 1.5 8.1 21.2 2.3 7.5 21.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Sec62 PF03839.16 ETO06894.1 - 2.1 7.8 21.2 6.9 6.1 19.6 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 BBL5 PF07289.11 ETO06894.1 - 2.3 7.2 10.0 6.3 5.7 10.0 1.8 1 1 0 1 1 1 0 Bardet-Biedl syndrome 5 protein XRN_M PF17846.1 ETO06894.1 - 2.3 7.1 12.1 3.8 6.4 12.1 1.3 1 0 0 1 1 1 0 Xrn1 helical domain hDGE_amylase PF14701.6 ETO06894.1 - 2.5 7.1 10.0 3.6 6.6 10.0 1.1 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain SDA1 PF05285.12 ETO06894.1 - 2.6 7.4 34.5 0.44 9.9 25.9 2.0 2 0 0 2 2 2 0 SDA1 Presenilin PF01080.17 ETO06894.1 - 4 6.1 13.6 6.6 5.4 13.6 1.3 1 0 0 1 1 1 0 Presenilin PA26 PF04636.13 ETO06894.1 - 4 6.2 11.0 5.6 5.8 11.0 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) O-antigen_lig PF13425.6 ETO06894.1 - 4.9 5.8 8.5 3.1 6.5 6.5 1.7 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Membralin PF09746.9 ETO06894.1 - 5 6.1 6.3 7.5 5.5 6.3 1.3 1 0 0 1 1 1 0 Tumour-associated protein Zip PF02535.22 ETO06894.1 - 5.1 6.2 7.1 7.6 5.6 7.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter FHIPEP PF00771.20 ETO06894.1 - 5.7 5.3 6.3 7.9 4.8 6.3 1.2 1 0 0 1 1 1 0 FHIPEP family Mem_trans PF03547.18 ETO06894.1 - 6.8 5.0 5.2 9.6 4.5 5.2 1.2 1 0 0 1 1 1 0 Membrane transport protein SURF2 PF05477.11 ETO06894.1 - 6.8 6.3 24.0 0.1 12.2 16.3 1.7 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) AAA_11 PF13086.6 ETO06894.1 - 8 6.2 12.6 5.5 6.7 10.1 1.8 2 0 0 2 2 2 0 AAA domain CLN3 PF02487.17 ETO06894.1 - 8.9 5.2 6.8 14 4.6 6.8 1.3 1 0 0 1 1 1 0 CLN3 protein UpxZ PF06603.11 ETO06896.1 - 0.032 14.5 0.3 0.24 11.7 0.1 2.3 2 1 1 3 3 3 0 UpxZ family of transcription anti-terminator antagonists VHS PF00790.19 ETO06896.1 - 0.038 13.8 1.1 0.17 11.7 0.0 2.1 2 1 1 3 3 3 0 VHS domain EDS1_EP PF18117.1 ETO06896.1 - 0.058 13.9 2.1 0.24 11.9 0.6 2.4 2 1 0 2 2 2 0 Enhanced disease susceptibility 1 protein EP domain PUF PF00806.19 ETO06901.1 - 5.5e-07 28.9 0.1 0.057 13.1 0.0 3.1 3 0 0 3 3 3 2 Pumilio-family RNA binding repeat CEP63 PF17045.5 ETO06902.1 - 0.0054 16.7 2.0 0.0054 16.7 2.0 2.6 2 1 1 3 3 3 1 Centrosomal protein of 63 kDa FlaC_arch PF05377.11 ETO06902.1 - 0.011 16.1 5.3 2 8.9 0.4 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 ETO06902.1 - 0.011 15.4 15.8 0.14 12.0 1.3 3.3 2 1 2 4 4 4 0 Septum formation initiator FSAP_sig_propep PF03032.15 ETO06902.1 - 0.037 14.1 1.0 0.21 11.7 1.0 2.3 1 1 0 1 1 1 0 Frog skin active peptide family signal and propeptide ATP-sulfurylase PF01747.17 ETO06902.1 - 0.038 13.5 0.1 0.056 12.9 0.1 1.3 1 0 0 1 1 1 0 ATP-sulfurylase BLOC1S3 PF15753.5 ETO06902.1 - 0.047 13.8 0.8 0.047 13.8 0.8 2.7 1 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 Cep57_CLD_2 PF14197.6 ETO06902.1 - 0.059 13.5 8.4 2.5 8.2 1.0 2.8 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Cnd1_N PF12922.7 ETO06902.1 - 0.13 12.1 7.0 0.047 13.5 4.1 1.8 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term YabA PF06156.13 ETO06902.1 - 0.25 12.0 13.2 0.71 10.5 7.1 2.6 1 1 1 2 2 2 0 Initiation control protein YabA GIT_CC PF16559.5 ETO06902.1 - 0.26 11.2 10.0 1.5 8.8 3.8 2.7 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor ApoO PF09769.9 ETO06902.1 - 0.27 11.2 1.1 1.8 8.5 0.1 2.1 2 0 0 2 2 2 0 Apolipoprotein O TSC22 PF01166.18 ETO06902.1 - 0.37 11.1 4.8 2.8 8.3 0.6 2.8 2 1 1 3 3 3 0 TSC-22/dip/bun family KfrA_N PF11740.8 ETO06902.1 - 1 10.1 6.5 4.8 7.9 0.3 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term ZapB PF06005.12 ETO06902.1 - 2.2 8.8 19.1 9.3e+03 -2.8 19.1 3.0 1 1 0 1 1 1 0 Cell division protein ZapB TMF_TATA_bd PF12325.8 ETO06902.1 - 2.7 8.2 17.2 0.32 11.2 0.9 2.7 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding K-box PF01486.17 ETO06902.1 - 4.7 7.5 15.1 1.2 9.4 0.2 3.1 3 1 0 3 3 3 0 K-box region Mak10 PF04112.13 ETO06905.1 - 0.0058 16.2 0.1 0.046 13.2 0.0 2.2 2 1 0 2 2 2 1 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Pkinase PF00069.25 ETO06906.1 - 9.7e-16 57.9 0.0 5.6e-14 52.1 0.0 2.8 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO06906.1 - 1.8e-06 27.5 0.1 3.2e-06 26.6 0.1 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO06906.1 - 4.2e-06 25.8 0.0 6.1e-06 25.3 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO06906.1 - 0.00022 20.7 0.1 0.00036 20.0 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO06906.1 - 0.023 14.3 0.2 0.041 13.5 0.2 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ETO06906.1 - 0.11 12.4 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4829 PF16111.5 ETO06908.1 - 2 9.2 7.8 0.25 12.1 0.5 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4829) Metallophos PF00149.28 ETO06909.1 - 1.3e-28 101.0 0.2 1.6e-28 100.6 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Palm_thioest PF02089.15 ETO06909.1 - 0.13 12.1 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Palmitoyl protein thioesterase WD40 PF00400.32 ETO06911.1 - 1.1e-18 67.2 12.1 6.8e-06 26.7 1.8 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06911.1 - 3.2e-09 36.9 0.1 0.0026 18.0 0.0 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06911.1 - 1.6e-06 27.7 2.9 0.0041 16.5 0.5 2.9 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO06911.1 - 1.6e-06 27.1 0.5 0.77 8.3 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO06911.1 - 0.001 18.8 0.5 0.012 15.4 0.0 2.3 2 0 0 2 2 2 1 ATP-dependent RecD-like DNA helicase SH3 domain Transglut_core PF01841.19 ETO06912.1 - 2.4e-11 44.1 0.0 5.6e-11 42.9 0.0 1.7 1 0 0 1 1 1 1 Transglutaminase-like superfamily Mucin PF01456.17 ETO06912.1 - 0.0035 17.3 4.6 0.0096 15.9 4.6 1.7 1 0 0 1 1 1 1 Mucin-like glycoprotein V-set_CD47 PF08204.11 ETO06912.1 - 0.019 15.0 1.1 0.065 13.2 0.1 2.4 2 0 0 2 2 2 0 CD47 immunoglobulin-like domain DUF553 PF04473.12 ETO06912.1 - 0.034 13.7 0.2 0.14 11.6 0.2 2.1 1 1 0 1 1 1 0 Transglutaminase-like domain DUF3439 PF11921.8 ETO06912.1 - 0.077 13.0 4.3 0.24 11.4 4.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Chorion_2 PF03964.15 ETO06912.1 - 3.1 8.7 6.1 1.3 9.9 2.4 2.2 2 0 0 2 2 2 0 Chorion family 2 Utp21 PF04192.12 ETO06912.1 - 3.7 7.0 8.1 5.4 6.4 0.1 3.7 4 0 0 4 4 4 0 Utp21 specific WD40 associated putative domain V_ATPase_I PF01496.19 ETO06913.1 - 0.00064 17.8 2.9 0.0032 15.5 2.5 2.1 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family LAP1C PF05609.12 ETO06913.1 - 0.017 14.3 11.9 0.008 15.3 9.7 1.5 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) DUF2721 PF11026.8 ETO06913.1 - 0.15 12.0 0.2 0.15 12.0 0.2 3.3 3 2 0 3 3 3 0 Protein of unknown function (DUF2721) CDC45 PF02724.14 ETO06913.1 - 0.59 8.4 12.6 0.94 7.7 12.6 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 ETO06913.1 - 1.8 7.5 16.7 1.6 7.7 15.6 1.4 1 1 0 1 1 1 0 Solute carrier family 12 DUF373 PF04123.13 ETO06913.1 - 4.4 6.7 6.9 0.51 9.7 1.1 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF373) WD40 PF00400.32 ETO06914.1 - 7.9e-13 48.7 14.4 1e-05 26.1 0.8 4.4 3 1 1 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06914.1 - 7.7e-07 29.3 0.0 0.012 15.9 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO06914.1 - 0.00058 18.6 0.1 0.006 15.3 0.3 1.9 1 1 0 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO06914.1 - 0.003 16.9 0.1 0.26 10.6 0.2 2.2 2 0 0 2 2 2 2 WD40-like domain Pkinase_Tyr PF07714.17 ETO06916.1 - 3.7e-67 226.3 0.0 4.5e-67 226.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO06916.1 - 1.2e-51 175.6 0.0 1.7e-51 175.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO06916.1 - 8.8e-09 34.6 0.0 1.5e-08 33.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO06916.1 - 6.7e-05 22.3 0.2 0.0001 21.8 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO06916.1 - 0.049 12.9 0.0 0.075 12.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like CLASP_N PF12348.8 ETO06919.1 - 0.00012 21.8 0.2 0.0062 16.1 0.1 2.3 2 0 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 ETO06919.1 - 0.00031 20.8 1.2 2 8.5 0.1 3.0 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 CBF PF03914.17 ETO06919.1 - 0.012 15.6 0.1 0.019 15.0 0.1 1.3 1 0 0 1 1 1 0 CBF/Mak21 family WD40 PF00400.32 ETO06920.1 - 1.4e-11 44.7 11.3 0.00017 22.3 0.9 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06920.1 - 1.8e-06 28.1 0.5 0.2 12.0 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Menin PF05053.13 ETO06920.1 - 0.11 10.8 4.4 0.16 10.3 4.4 1.1 1 0 0 1 1 1 0 Menin Orf78 PF06024.12 ETO06920.1 - 3.6 8.0 9.1 1.4 9.2 6.4 1.7 2 0 0 2 2 2 0 Orf78 (ac78) Ank_4 PF13637.6 ETO06921.1 - 9.2e-15 54.8 0.2 3.3e-10 40.3 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO06921.1 - 2.6e-13 50.3 1.7 3.8e-11 43.4 0.3 2.8 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO06921.1 - 9.9e-13 47.1 0.4 9e-05 22.6 0.0 4.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ETO06921.1 - 2e-08 34.3 0.0 0.0047 17.3 0.0 4.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO06921.1 - 7.5e-07 29.3 0.6 0.0024 18.2 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (many copies) IFRD PF05004.13 ETO06925.1 - 0.06 12.4 5.2 0.074 12.1 5.2 1.0 1 0 0 1 1 1 0 Interferon-related developmental regulator (IFRD) XAP5 PF04921.14 ETO06925.1 - 0.41 10.4 8.1 0.47 10.2 8.1 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator Presenilin PF01080.17 ETO06925.1 - 1.8 7.2 4.5 1.8 7.2 4.5 1.0 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ETO06925.1 - 2.8 8.2 13.6 3.6 7.9 13.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FAM176 PF14851.6 ETO06925.1 - 6.8 6.4 8.3 8.2 6.1 8.3 1.2 1 0 0 1 1 1 0 FAM176 family Ank_2 PF12796.7 ETO06928.1 - 3e-30 104.6 0.2 2.7e-17 63.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO06928.1 - 1e-18 67.4 0.1 6.1e-10 39.4 0.0 3.7 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO06928.1 - 2.9e-18 64.0 0.1 2.5e-06 27.4 0.0 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 ETO06928.1 - 1.1e-13 51.0 0.1 2.5e-05 24.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ETO06928.1 - 2.3e-12 46.9 0.0 1.6e-05 25.1 0.0 3.8 1 1 3 4 4 4 2 Ankyrin repeats (many copies) GATA PF00320.27 ETO06928.1 - 0.2 11.3 2.6 1.4 8.6 0.3 2.6 2 0 0 2 2 2 0 GATA zinc finger Pyrophosphatase PF00719.19 ETO06929.1 - 0.047 13.5 2.4 0.05 13.4 2.4 1.1 1 0 0 1 1 1 0 Inorganic pyrophosphatase Na_trans_assoc PF06512.13 ETO06929.1 - 0.083 13.2 1.9 0.099 12.9 1.9 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated HECW1_helix PF18436.1 ETO06929.1 - 0.27 11.4 5.1 0.27 11.4 3.8 1.7 1 1 1 2 2 2 0 Helical box domain of E3 ubiquitin-protein ligase HECW1 RNA_pol_I_A49 PF06870.12 ETO06931.1 - 2.9e-06 26.4 0.1 3.5e-06 26.1 0.1 1.1 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Hist_deacetyl PF00850.19 ETO06932.1 - 1.4e-71 241.5 0.4 4.6e-71 239.8 0.1 1.7 2 0 0 2 2 2 1 Histone deacetylase domain Orf78 PF06024.12 ETO06933.1 - 0.43 10.9 6.6 2.8 8.3 2.5 3.0 3 0 0 3 3 3 0 Orf78 (ac78) SLC12 PF03522.15 ETO06934.1 - 0.91 8.5 6.2 2.4 7.1 0.0 2.1 2 0 0 2 2 2 0 Solute carrier family 12 cNMP_binding PF00027.29 ETO06935.1 - 7.1e-15 54.9 0.0 6.4e-06 26.2 0.0 3.2 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain DUF5603 PF18231.1 ETO06935.1 - 0.017 15.4 0.1 0.075 13.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5603) Pkinase PF00069.25 ETO06936.1 - 8.9e-05 22.0 0.0 0.00018 21.0 0.0 1.5 2 0 0 2 2 2 1 Protein kinase domain DUF3277 PF11681.8 ETO06937.1 - 1.5 8.7 8.2 0.096 12.6 1.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3277) GYF_2 PF14237.6 ETO06938.1 - 5.1e-06 26.2 0.0 1.1e-05 25.1 0.0 1.6 1 0 0 1 1 1 1 GYF domain 2 GYF PF02213.16 ETO06938.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 GYF domain NUDIX PF00293.28 ETO06939.1 - 8.7e-10 38.8 0.1 4.3e-05 23.6 0.0 3.2 3 1 0 3 3 3 2 NUDIX domain Aminotran_1_2 PF00155.21 ETO06940.1 - 2.5e-09 36.8 0.0 3.9e-09 36.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_1_2 PF00155.21 ETO06941.1 - 5.3e-09 35.7 0.0 6.1e-09 35.5 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II PFK PF00365.20 ETO06942.1 - 5.3e-40 137.5 0.1 7.1e-40 137.1 0.1 1.1 1 0 0 1 1 1 1 Phosphofructokinase Ribosomal_S5 PF00333.20 ETO06942.1 - 0.12 12.4 0.6 1.3 9.0 0.0 2.6 2 1 0 2 2 2 0 Ribosomal protein S5, N-terminal domain PFK PF00365.20 ETO06943.1 - 0.002 17.5 0.0 0.0045 16.4 0.0 1.6 1 1 1 2 2 2 1 Phosphofructokinase Pox_LP_H2 PF03356.15 ETO06943.1 - 0.01 15.7 0.2 0.017 15.0 0.2 1.3 1 0 0 1 1 1 0 Viral late protein H2 Nucleoside_tran PF01733.18 ETO06943.1 - 0.014 14.8 0.4 0.02 14.3 0.4 1.2 1 0 0 1 1 1 0 Nucleoside transporter Sarcoglycan_1 PF04790.13 ETO06943.1 - 0.015 14.7 2.4 0.022 14.1 2.4 1.2 1 0 0 1 1 1 0 Sarcoglycan complex subunit protein Phage_holin_T PF11031.8 ETO06943.1 - 0.037 13.5 0.6 0.066 12.7 0.6 1.3 1 0 0 1 1 1 0 Bacteriophage T holin Ly49 PF08391.10 ETO06943.1 - 0.043 14.2 1.9 0.11 12.9 1.9 1.7 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region DUF4446 PF14584.6 ETO06943.1 - 0.098 12.6 1.8 0.19 11.7 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Noggin PF05806.12 ETO06943.1 - 0.21 11.5 1.4 1.3 8.8 1.1 2.0 2 0 0 2 2 2 0 Noggin Peptidase_S49_N PF08496.10 ETO06943.1 - 0.3 11.2 2.0 0.29 11.2 0.7 1.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ac76 PF05814.11 ETO06943.1 - 0.43 10.6 7.7 0.1 12.6 4.1 1.9 2 0 0 2 2 2 0 Orf76 (Ac76) RabGAP-TBC PF00566.18 ETO06944.1 - 2.6e-23 82.8 0.3 2.6e-23 82.8 0.3 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Chordopox_A30L PF06015.12 ETO06944.1 - 0.081 12.8 0.1 0.68 9.8 0.0 2.5 2 0 0 2 2 2 0 Chordopoxvirus A30L protein Pneumo_att_G PF05539.11 ETO06944.1 - 2.2 7.8 7.5 3.6 7.1 7.5 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G EFTUD2 PF16004.5 ETO06946.1 - 0.0011 19.6 3.6 0.0011 19.6 3.6 6.0 5 2 0 5 5 5 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DUF4296 PF14129.6 ETO06946.1 - 0.0043 17.6 3.4 0.0043 17.6 3.4 3.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4296) Ribosomal_60s PF00428.19 ETO06946.1 - 0.022 15.3 0.3 0.022 15.3 0.3 5.5 4 1 0 4 4 4 0 60s Acidic ribosomal protein DJ-1_PfpI PF01965.24 ETO06949.1 - 3.6e-10 39.9 0.0 1.1e-09 38.3 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family ThiJ_like PF17124.5 ETO06949.1 - 6e-06 26.1 0.1 0.00027 20.7 0.1 2.2 1 1 0 1 1 1 1 ThiJ/PfpI family-like DUF3611 PF12263.8 ETO06950.1 - 4.4 7.2 8.2 3.3 7.6 1.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3611) RGS PF00615.19 ETO06951.1 - 4.8e-05 23.6 0.0 5.8e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain MtrG PF04210.13 ETO06952.1 - 1.2 9.1 7.2 0.5 10.3 0.1 3.4 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G PspA_IM30 PF04012.12 ETO06952.1 - 4.7 6.7 43.3 0.81 9.2 0.9 6.1 3 2 1 4 4 4 0 PspA/IM30 family TLD PF07534.16 ETO06953.1 - 2.9e-13 50.3 1.9 6.2e-13 49.2 1.0 1.9 1 1 1 2 2 2 1 TLD BBS2_Mid PF14783.6 ETO06953.1 - 0.12 12.4 0.2 0.65 10.1 0.1 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region zf-FCS PF06467.14 ETO06954.1 - 0.58 10.1 3.6 6.2 6.8 0.1 3.3 2 1 1 3 3 3 0 MYM-type Zinc finger with FCS sequence motif OST-HTH PF12872.7 ETO06957.1 - 3e-05 23.7 0.1 0.0053 16.5 0.0 3.3 3 0 0 3 3 3 1 OST-HTH/LOTUS domain CCDC24 PF15669.5 ETO06957.1 - 0.023 14.6 0.7 0.058 13.3 0.7 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family HpaP PF09483.10 ETO06957.1 - 0.18 12.1 1.1 1.2 9.5 0.0 2.8 3 0 0 3 3 3 0 Type III secretion protein (HpaP) DUF1980 PF09323.10 ETO06957.1 - 0.23 11.4 4.4 0.57 10.1 4.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CPSF100_C PF13299.6 ETO06957.1 - 0.34 11.1 3.8 0.91 9.7 3.8 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal EIIBC-GUT_N PF03612.14 ETO06957.1 - 0.68 9.7 3.2 0.99 9.1 2.3 1.7 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus RXT2_N PF08595.11 ETO06957.1 - 6.6 6.7 11.5 2.9 7.9 8.2 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal Lipoprotein_Ltp PF07553.11 ETO06959.1 - 0.14 12.4 0.1 0.36 11.1 0.1 1.6 1 0 0 1 1 1 0 Host cell surface-exposed lipoprotein WD40 PF00400.32 ETO06960.1 - 1.1e-20 73.5 10.6 9.7e-08 32.6 0.2 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO06960.1 - 4.3e-09 35.6 0.2 1.2e-05 24.2 0.3 2.0 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO06960.1 - 5.5e-06 26.6 0.0 0.0033 17.7 0.0 2.3 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO06960.1 - 0.002 17.5 0.3 0.18 11.1 0.2 2.5 1 1 2 3 3 3 2 WD40-like domain Enolase_like_N PF18374.1 ETO06960.1 - 0.24 10.8 0.4 0.76 9.2 0.1 1.9 2 0 0 2 2 2 0 Enolase N-terminal domain-like Exonuc_VII_S PF02609.16 ETO06961.1 - 0.19 11.8 2.7 0.53 10.4 0.1 2.7 3 0 0 3 3 3 0 Exonuclease VII small subunit Apc15p PF05841.11 ETO06961.1 - 3.1 8.6 9.1 5.2 7.9 5.6 2.3 2 0 0 2 2 2 0 Apc15p protein PHD PF00628.29 ETO06962.1 - 8.7e-05 22.3 4.8 8.7e-05 22.3 4.8 2.3 3 0 0 3 3 3 1 PHD-finger Phage_term_smal PF05944.12 ETO06962.1 - 0.068 13.1 0.0 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Phage small terminase subunit Macoilin PF09726.9 ETO06963.1 - 0.031 12.9 16.2 0.034 12.7 16.2 1.0 1 0 0 1 1 1 0 Macoilin family UCH PF00443.29 ETO06964.1 - 9.3e-45 153.1 8.0 9.3e-45 153.1 8.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO06964.1 - 1.2e-18 67.8 13.8 1.2e-18 67.8 13.8 3.2 3 2 1 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase Curto_V3 PF07436.11 ETO06964.1 - 0.095 13.1 0.3 4.8 7.6 0.0 3.6 4 0 0 4 4 4 0 Curtovirus V3 protein Lipase_3 PF01764.25 ETO06965.1 - 1.3e-15 57.5 0.0 1.8e-15 57.0 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Lipase_3 PF01764.25 ETO06966.1 - 0.0012 18.7 0.0 0.002 18.0 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) SRP72 PF08492.12 ETO06966.1 - 0.82 10.2 9.5 4.2 7.9 3.7 2.2 2 0 0 2 2 2 0 SRP72 RNA-binding domain LmjF365940-deam PF14421.6 ETO06967.1 - 0.0031 17.1 0.0 0.0045 16.6 0.0 1.3 1 0 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.23 ETO06967.1 - 0.069 13.0 0.2 0.49 10.3 0.5 1.9 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region PAP_assoc PF03828.19 ETO06968.1 - 5.6e-05 23.3 0.1 9.6e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase PAP_central PF04928.17 ETO06969.1 - 0.04 12.9 0.1 0.063 12.3 0.1 1.5 1 0 0 1 1 1 0 Poly(A) polymerase central domain PP2C PF00481.21 ETO06970.1 - 9.2e-40 136.9 0.0 1.1e-39 136.6 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 ETO06970.1 - 0.065 12.9 0.0 0.57 9.8 0.0 2.0 1 1 0 1 1 1 0 Protein phosphatase 2C PCMT PF01135.19 ETO06971.1 - 3e-17 63.1 0.0 3.6e-17 62.8 0.0 1.0 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ETO06971.1 - 8.7e-05 22.4 0.0 0.00011 22.1 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO06971.1 - 0.0018 18.9 0.0 0.0027 18.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO06971.1 - 0.0054 16.7 0.0 0.0068 16.4 0.0 1.3 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ETO06971.1 - 0.0063 16.6 0.0 0.008 16.3 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_24 PF13578.6 ETO06971.1 - 0.061 14.4 0.0 0.08 14.0 0.0 1.2 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_3 PF01596.17 ETO06971.1 - 0.072 12.3 0.0 0.079 12.1 0.0 1.1 1 0 0 1 1 1 0 O-methyltransferase Methyltransf_12 PF08242.12 ETO06971.1 - 0.082 13.7 0.0 0.14 13.0 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ETO06972.1 - 2.1e-06 27.7 0.0 2.9e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Pex24p PF06398.11 ETO06972.1 - 0.054 12.5 0.0 0.063 12.3 0.0 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF2981 PF11200.8 ETO06973.1 - 1.5 8.5 6.3 1.7 8.3 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SR-25 PF10500.9 ETO06973.1 - 3.6 7.2 38.6 7.8 6.0 38.7 1.5 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Mid2 PF04478.12 ETO06974.1 - 0.0015 18.4 2.4 0.0023 17.8 2.4 1.3 1 0 0 1 1 1 1 Mid2 like cell wall stress sensor DUF1616 PF07760.11 ETO06974.1 - 0.018 14.4 0.1 0.023 14.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) DUF5305 PF17231.2 ETO06974.1 - 0.097 12.1 1.0 0.14 11.5 1.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5305) cNMP_binding PF00027.29 ETO06975.1 - 1.8e-10 40.8 0.0 3.7e-10 39.7 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF1599 PF07659.11 ETO06975.1 - 0.017 15.6 0.2 0.017 15.6 0.2 2.4 2 1 1 3 3 3 0 Nucleotide modification associated domain 1 DUF3774 PF12609.8 ETO06975.1 - 0.68 11.0 8.1 0.55 11.3 5.7 1.9 1 1 1 2 2 2 0 Wound-induced protein Drf_GBD PF06371.13 ETO06976.1 - 1.6e-13 50.6 1.9 3.6e-13 49.5 1.9 1.5 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain DUF3361 PF11841.8 ETO06976.1 - 0.00067 19.6 0.0 0.0024 17.8 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) RTTN_N PF14726.6 ETO06976.1 - 0.081 13.7 0.9 10 7.0 0.4 2.5 2 1 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning PH PF00169.29 ETO06976.1 - 0.13 12.8 0.4 3.4 8.2 0.2 3.0 2 0 0 2 2 2 0 PH domain EGF_2 PF07974.13 ETO06977.1 - 0.00057 20.2 1.2 0.0013 19.1 1.2 1.5 1 0 0 1 1 1 1 EGF-like domain Presenilin PF01080.17 ETO06977.1 - 3.7 6.2 5.8 6.1 5.5 5.8 1.4 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO06978.1 - 0.0015 17.5 4.9 0.0016 17.4 4.9 1.1 1 0 0 1 1 1 1 Aluminium activated malate transporter Menin PF05053.13 ETO06978.1 - 0.0091 14.4 4.6 0.0093 14.4 4.6 1.1 1 0 0 1 1 1 1 Menin CSG2 PF16965.5 ETO06978.1 - 0.048 12.6 1.2 0.046 12.7 1.2 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator SKA1 PF07160.12 ETO06978.1 - 0.44 10.4 7.1 0.75 9.6 7.1 1.4 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Med21 PF11221.8 ETO06978.1 - 0.82 9.9 4.6 1.4 9.2 4.6 1.4 1 0 0 1 1 1 0 Subunit 21 of Mediator complex CAP_GLY PF01302.25 ETO06979.1 - 8e-08 32.2 4.1 0.0022 18.0 0.3 2.6 3 0 0 3 3 3 2 CAP-Gly domain DUSP PF06337.12 ETO06981.1 - 9.8e-11 42.1 0.3 2.1e-10 41.1 0.0 1.7 2 0 0 2 2 2 1 DUSP domain BRF1 PF07741.13 ETO06981.1 - 0.03 14.7 5.0 0.059 13.7 5.0 1.5 1 0 0 1 1 1 0 Brf1-like TBP-binding domain SIP1 PF04938.12 ETO06982.1 - 0.0045 16.7 0.8 0.0056 16.4 0.8 1.1 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) Secretin_N_2 PF07655.13 ETO06982.1 - 0.021 15.4 6.6 0.03 14.9 6.6 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Ctr PF04145.15 ETO06982.1 - 0.12 13.0 0.6 0.15 12.7 0.6 1.2 1 0 0 1 1 1 0 Ctr copper transporter family ALMT PF11744.8 ETO06982.1 - 1.1 8.0 5.1 1.2 7.9 5.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter ASL_C PF08328.11 ETO06983.1 - 0.035 14.2 1.1 1.2 9.3 0.1 3.0 3 0 0 3 3 3 0 Adenylosuccinate lyase C-terminal TINF2_N PF14973.6 ETO06983.1 - 7.4 6.9 9.1 0.33 11.3 1.5 2.6 4 0 0 4 4 4 0 TERF1-interacting nuclear factor 2 N-terminus Arf PF00025.21 ETO06984.1 - 3e-07 30.1 0.3 3.7e-07 29.8 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DS PF01916.17 ETO06985.1 - 1.8e-34 119.3 0.1 2.9e-34 118.6 0.1 1.2 1 0 0 1 1 1 1 Deoxyhypusine synthase DS PF01916.17 ETO06986.1 - 2.6e-63 214.0 0.0 3e-63 213.8 0.0 1.0 1 0 0 1 1 1 1 Deoxyhypusine synthase RAB3GAP2_N PF14655.6 ETO06989.1 - 7.9e-28 97.8 0.1 3.2e-19 69.5 0.0 2.3 2 0 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF4551 PF15087.6 ETO06989.1 - 0.39 9.5 4.1 0.65 8.8 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF1129 PF06570.11 ETO06992.1 - 0.015 14.8 0.1 0.017 14.7 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) TssO PF17561.2 ETO06992.1 - 0.86 9.7 9.5 12 6.0 1.2 3.0 2 1 1 3 3 3 0 Type VI secretion system, TssO Alpha_kinase PF02816.18 ETO06993.1 - 0.0012 19.0 0.0 0.0025 18.0 0.0 1.5 1 1 0 1 1 1 1 Alpha-kinase family WD40 PF00400.32 ETO06994.1 - 1.4e-65 215.6 11.8 1.5e-10 41.4 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO06994.1 - 2.5e-22 79.0 1.0 2.1e-05 24.7 0.0 6.1 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO06994.1 - 8.4e-12 45.4 0.1 5.3e-08 33.0 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO06994.1 - 1.5e-11 43.8 0.1 0.098 11.6 0.0 5.7 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO06994.1 - 4.9e-11 42.5 2.6 6.5e-05 22.4 0.1 3.8 2 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO06994.1 - 2.4e-07 29.6 0.9 0.0025 16.4 0.1 3.3 1 1 3 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO06994.1 - 4.3e-06 26.5 3.0 3 7.9 0.1 5.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO06994.1 - 1.4e-05 24.0 1.1 0.43 9.2 0.1 4.7 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO06994.1 - 2.5e-05 23.5 1.2 0.0011 18.0 0.4 2.3 1 1 1 2 2 2 1 Coatomer WD associated region Nbas_N PF15492.6 ETO06994.1 - 0.00039 19.8 1.1 1.1 8.5 0.0 3.9 2 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO06994.1 - 0.0006 19.9 0.2 6.7 6.8 0.0 4.3 2 1 3 5 5 5 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO06994.1 - 0.0029 17.2 0.0 0.36 10.4 0.0 2.4 1 1 0 2 2 2 1 PQQ-like domain PALB2_WD40 PF16756.5 ETO06994.1 - 0.0033 16.4 0.5 1.3 7.9 0.0 3.6 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF727 PF05303.12 ETO06994.1 - 0.0059 16.6 0.1 22 5.2 0.0 4.3 3 1 2 5 5 5 0 Protein of unknown function (DUF727) MMS1_N PF10433.9 ETO06994.1 - 0.0086 14.8 0.1 0.43 9.2 0.0 3.0 1 1 2 3 3 3 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term DPPIV_N PF00930.21 ETO06994.1 - 0.054 12.3 0.0 7 5.3 0.0 3.8 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ribosomal_L35p PF01632.19 ETO06994.1 - 0.078 13.5 0.2 0.45 11.0 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L35 Proteasome_A_N PF10584.9 ETO06994.1 - 3 7.6 10.9 48 3.8 0.1 5.5 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature TPR_12 PF13424.6 ETO06995.1 - 8e-21 74.1 3.7 1.4e-10 41.3 0.6 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO06995.1 - 1.6e-12 46.9 0.1 0.00036 20.3 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO06995.1 - 1.7e-11 43.3 0.4 0.0051 16.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO06995.1 - 7.5e-11 41.4 5.8 0.00079 19.1 2.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO06995.1 - 7.3e-09 35.1 3.7 0.013 15.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO06995.1 - 1.4e-08 34.2 5.1 0.014 15.5 1.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat SNAP PF14938.6 ETO06995.1 - 1.6e-06 27.8 0.3 2.4e-06 27.2 0.3 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO06995.1 - 2.9e-05 23.6 1.4 5.6 6.7 0.0 4.4 3 2 1 4 4 4 2 TPR repeat PSA_CBD PF18341.1 ETO06995.1 - 9.7e-05 22.3 2.5 9.7e-05 22.3 2.5 2.7 3 0 0 3 3 3 1 PSA endolysin C-terminal cell wall binding domain MIT PF04212.18 ETO06995.1 - 0.029 14.4 2.1 2.1 8.5 0.0 3.1 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO06995.1 - 0.033 14.8 0.0 16 6.4 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat APG17 PF04108.12 ETO06995.1 - 0.07 12.2 1.4 0.09 11.9 1.4 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 DUF5113 PF17140.4 ETO06995.1 - 0.083 12.7 3.8 0.13 12.1 1.3 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETO06995.1 - 0.14 11.5 0.1 0.18 11.1 0.1 1.1 1 0 0 1 1 1 0 MalT-like TPR region TPR_17 PF13431.6 ETO06995.1 - 0.15 12.5 0.7 2.4 8.7 0.1 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 ETO06995.1 - 0.95 10.5 3.0 15 6.9 0.2 3.7 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat AAA PF00004.29 ETO06996.1 - 2.9e-06 27.7 0.1 2.6e-05 24.7 0.0 2.7 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO06996.1 - 6.5e-05 23.2 0.2 0.0011 19.2 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_5 PF07728.14 ETO06996.1 - 0.00041 20.4 0.0 0.0018 18.3 0.0 2.2 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 ETO06996.1 - 0.00064 19.1 0.5 0.0073 15.7 0.0 2.9 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_16 PF13191.6 ETO06996.1 - 0.0021 18.5 0.8 0.037 14.4 0.0 3.0 3 1 1 4 4 4 1 AAA ATPase domain AAA_14 PF13173.6 ETO06996.1 - 0.0034 17.4 0.0 0.063 13.3 0.0 2.8 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ETO06996.1 - 0.008 16.5 0.1 2.4 8.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain MCM PF00493.23 ETO06996.1 - 0.008 15.3 0.1 0.1 11.7 0.0 2.3 2 0 0 2 2 2 1 MCM P-loop domain RsgA_GTPase PF03193.16 ETO06996.1 - 0.008 16.1 2.6 0.015 15.3 0.1 2.8 3 1 0 3 3 2 1 RsgA GTPase ABC_tran PF00005.27 ETO06996.1 - 0.0084 16.6 2.8 0.01 16.4 0.0 2.6 3 0 0 3 3 1 1 ABC transporter AAA_7 PF12775.7 ETO06996.1 - 0.01 15.4 0.0 0.036 13.6 0.0 1.9 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 ETO06996.1 - 0.021 14.8 0.0 0.069 13.2 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF815 PF05673.13 ETO06996.1 - 0.021 14.0 0.1 0.099 11.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ETO06996.1 - 0.023 14.4 0.1 0.11 12.3 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation MMR_HSR1 PF01926.23 ETO06996.1 - 0.047 13.8 0.5 13 5.9 0.0 3.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 ETO06996.1 - 0.05 14.0 0.0 0.4 11.1 0.0 2.6 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 ETO06996.1 - 0.076 12.9 0.1 0.45 10.4 0.1 2.4 1 0 0 1 1 1 0 NACHT domain DHC PF09626.10 ETO06996.1 - 4.6 8.1 7.6 1 10.2 0.3 3.5 4 0 0 4 4 4 0 Dihaem cytochrome c MRP-L47 PF06984.13 ETO06997.1 - 0.11 12.7 0.3 0.29 11.3 0.3 1.7 1 0 0 1 1 1 0 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) Goodbye PF17109.5 ETO06999.1 - 0.19 12.2 0.1 0.19 12.2 0.1 4.0 3 1 2 5 5 5 0 fungal STAND N-terminal Goodbye domain AI-2E_transport PF01594.16 ETO06999.1 - 0.2 10.8 2.1 0.48 9.5 0.4 1.9 1 1 1 2 2 2 0 AI-2E family transporter TPR_6 PF13174.6 ETO07000.1 - 0.00042 20.8 0.1 0.0012 19.3 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat PA26 PF04636.13 ETO07000.1 - 0.00083 18.4 1.5 0.0016 17.5 1.5 1.4 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) BORCS6 PF10157.9 ETO07000.1 - 0.012 15.9 0.6 0.037 14.3 0.6 1.8 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Dioxygenase_N PF04444.14 ETO07000.1 - 0.13 12.1 0.6 0.62 10.0 0.1 2.4 3 0 0 3 3 3 0 Catechol dioxygenase N terminus TFIIA PF03153.13 ETO07001.1 - 0.57 10.1 51.7 0.66 9.9 10.5 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Alpha_GJ PF03229.13 ETO07001.1 - 9.8 6.8 13.2 23 5.6 13.2 1.5 1 0 0 1 1 1 0 Alphavirus glycoprotein J Thioredoxin_8 PF13905.6 ETO07003.1 - 0.66 10.3 6.1 0.86 10.0 6.1 1.3 1 1 0 1 1 1 0 Thioredoxin-like DUF2397 PF09660.10 ETO07004.1 - 0.00041 19.4 1.3 0.0006 18.8 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2397) Mcm10 PF09332.11 ETO07004.1 - 0.012 15.1 12.8 0.014 14.8 12.7 1.3 1 1 0 1 1 1 0 Mcm10 replication factor SSP160 PF06933.11 ETO07004.1 - 2.5 6.2 8.0 3.6 5.7 8.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO07004.1 - 7.3 6.6 9.0 16 5.4 9.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TRM13 PF05206.14 ETO07005.1 - 0.024 14.1 1.9 0.037 13.6 1.3 1.4 2 0 0 2 2 2 0 Methyltransferase TRM13 SLC12 PF03522.15 ETO07005.1 - 0.36 9.8 6.2 0.034 13.2 1.9 1.4 2 0 0 2 2 2 0 Solute carrier family 12 Lin-8 PF03353.15 ETO07005.1 - 3 7.3 13.6 0.15 11.6 7.8 1.6 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Peptidase_S8 PF00082.22 ETO07009.1 - 8.2e-07 28.6 0.1 8.4e-07 28.5 0.1 1.1 1 0 0 1 1 1 1 Subtilase family HI0933_like PF03486.14 ETO07009.1 - 0.0062 15.3 0.1 0.028 13.1 0.1 1.8 1 1 1 2 2 2 1 HI0933-like protein PAS_11 PF14598.6 ETO07009.1 - 0.13 12.4 0.0 0.25 11.5 0.0 1.4 1 0 0 1 1 1 0 PAS domain Ras PF00071.22 ETO07010.1 - 2.2e-49 167.2 0.2 2.5e-49 167.0 0.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO07010.1 - 1.9e-23 82.9 0.0 3e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO07010.1 - 1.9e-08 34.0 0.0 2.1e-08 33.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO07010.1 - 0.00023 20.8 0.0 0.00031 20.3 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO07010.1 - 0.056 12.8 0.0 0.077 12.3 0.0 1.2 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region CENP-B_N PF04218.13 ETO07010.1 - 0.091 12.4 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 CENP-B N-terminal DNA-binding domain EMP70 PF02990.16 ETO07011.1 - 3.3e-44 151.4 22.1 3.3e-44 151.4 22.1 1.4 2 0 0 2 2 2 1 Endomembrane protein 70 PMP1_2 PF08114.11 ETO07011.1 - 0.015 15.0 2.1 0.038 13.7 2.1 1.6 1 0 0 1 1 1 0 ATPase proteolipid family HTH_30 PF13556.6 ETO07011.1 - 0.07 13.0 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DHHC PF01529.20 ETO07011.1 - 7.8 6.6 20.2 8.2 6.5 0.1 2.9 1 1 2 3 3 3 0 DHHC palmitoyltransferase EMP70 PF02990.16 ETO07012.1 - 5.2e-44 150.8 8.2 6.3e-44 150.5 8.2 1.0 1 0 0 1 1 1 1 Endomembrane protein 70 THB PF18362.1 ETO07012.1 - 0.0048 16.5 1.9 0.017 14.7 0.1 2.3 1 1 1 2 2 2 1 Tri-helix bundle domain EcsB PF05975.12 ETO07012.1 - 0.016 14.0 9.6 0.026 13.4 9.6 1.3 1 0 0 1 1 1 0 Bacterial ABC transporter protein EcsB DMT_YdcZ PF04657.13 ETO07012.1 - 0.047 14.0 5.0 2.5 8.4 4.9 2.2 2 0 0 2 2 2 0 Putative inner membrane exporter, YdcZ DUF1129 PF06570.11 ETO07012.1 - 0.67 9.4 9.9 0.86 9.1 9.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) DUF2070 PF09843.9 ETO07012.1 - 3 6.0 10.1 3.9 5.7 10.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) CPP1-like PF11833.8 ETO07012.1 - 3.2 7.3 7.6 0.99 9.0 3.1 2.0 1 1 1 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like TMEM43 PF07787.12 ETO07012.1 - 5.3 6.3 7.1 1.8 7.9 4.2 1.6 1 1 0 2 2 2 0 Transmembrane protein 43 PI-PLC-Y PF00387.19 ETO07013.1 - 0.087 13.2 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, Y domain DNA_ligase_A_M PF01068.21 ETO07016.1 - 0.018 14.7 0.0 0.025 14.2 0.0 1.3 1 0 0 1 1 1 0 ATP dependent DNA ligase domain DHC_N2 PF08393.13 ETO07017.1 - 1.5e-95 320.7 9.9 1.5e-95 320.7 9.9 1.7 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 ETO07017.1 - 1.5e-56 191.8 0.1 3.6e-56 190.5 0.1 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region Helitron_like_N PF14214.6 ETO07017.1 - 0.014 15.6 0.2 0.058 13.6 0.1 2.1 2 0 0 2 2 2 0 Helitron helicase-like domain at N-terminus AAA PF00004.29 ETO07017.1 - 0.015 15.8 0.2 0.23 11.9 0.0 3.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Nbl1_Borealin_N PF10444.9 ETO07017.1 - 0.058 13.0 0.2 0.99 9.1 0.1 2.9 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal AAA_22 PF13401.6 ETO07017.1 - 0.066 13.5 0.3 0.59 10.4 0.0 2.7 4 0 0 4 4 4 0 AAA domain FliD_N PF02465.18 ETO07017.1 - 0.092 13.4 1.8 4.6 8.0 0.0 3.2 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus WD40 PF00400.32 ETO07018.1 - 9.2e-38 127.6 26.7 1.3e-06 29.0 0.6 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07018.1 - 3.6e-10 40.0 0.7 0.26 11.6 0.0 4.9 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07018.1 - 1.5e-08 33.8 4.5 0.27 9.8 0.1 5.0 1 1 3 6 6 6 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO07018.1 - 9.6e-06 26.2 1.1 9.6e-06 26.2 1.1 2.8 2 0 0 2 2 2 1 TRAF-type zinc finger Exonuc_VII_L PF02601.15 ETO07018.1 - 0.15 11.6 4.7 0.23 11.0 4.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF413 PF04219.12 ETO07018.1 - 0.22 11.6 1.3 0.49 10.4 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF Laminin_II PF06009.12 ETO07018.1 - 0.22 11.5 7.5 0.49 10.4 7.5 1.6 1 0 0 1 1 1 0 Laminin Domain II GyrB_insert PF18053.1 ETO07018.1 - 0.23 11.3 4.8 0.43 10.5 4.8 1.3 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain IMD PF08397.11 ETO07018.1 - 1.4 8.2 12.5 2.8 7.3 12.5 1.4 1 0 0 1 1 1 0 IRSp53/MIM homology domain TMEM70 PF06979.12 ETO07019.1 - 2.2e-12 47.5 1.1 2.9e-12 47.1 1.1 1.2 1 0 0 1 1 1 1 Assembly, mitochondrial proton-transport ATP synth complex TMEM223 PF14640.6 ETO07019.1 - 0.004 17.3 0.5 0.0065 16.6 0.5 1.4 1 1 0 1 1 1 1 Transmembrane protein 223 DUF2541 PF10807.8 ETO07019.1 - 0.064 13.3 0.0 0.089 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2541) Spc7 PF08317.11 ETO07021.1 - 0.017 14.1 22.3 0.052 12.4 7.4 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF2838 PF10998.8 ETO07021.1 - 0.022 15.0 0.7 0.038 14.2 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2838) MFS_2 PF13347.6 ETO07024.1 - 5.7e-06 25.1 5.3 1.3e-05 24.0 5.3 1.5 1 0 0 1 1 1 1 MFS/sugar transport protein MFS_1 PF07690.16 ETO07024.1 - 3.2e-05 23.0 7.9 0.011 14.7 8.9 2.3 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO07024.1 - 0.033 13.1 9.2 0.023 13.6 6.4 2.0 1 1 0 2 2 2 0 Sugar (and other) transporter DPM2 PF07297.12 ETO07024.1 - 1.1 9.6 6.3 2.1 8.7 0.3 3.8 2 1 1 3 3 3 0 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) Secretin_N_2 PF07655.13 ETO07025.1 - 0.68 10.5 3.6 9.7 6.8 0.0 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain STAG PF08514.11 ETO07026.1 - 4.3e-05 23.4 1.8 4.3e-05 23.4 1.8 2.3 1 1 2 3 3 3 1 STAG domain DUF3402 PF11882.8 ETO07026.1 - 0.00041 19.6 4.4 0.0005 19.3 4.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3402) RasGAP PF00616.19 ETO07026.1 - 0.00098 18.9 3.4 0.0013 18.5 3.4 1.3 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase TMEM214 PF10151.9 ETO07026.1 - 0.0099 14.4 4.6 0.011 14.3 4.6 1.1 1 0 0 1 1 1 1 TMEM214, C-terminal, caspase 4 activator Vfa1 PF08432.10 ETO07026.1 - 0.02 15.2 10.0 0.027 14.8 10.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 ETO07026.1 - 0.026 14.7 3.1 0.028 14.6 3.1 1.1 1 0 0 1 1 1 0 DDHD domain TrwB_AAD_bind PF10412.9 ETO07026.1 - 0.028 13.3 1.2 0.037 13.0 1.2 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain FAM176 PF14851.6 ETO07026.1 - 0.034 13.8 5.5 0.048 13.3 5.5 1.2 1 0 0 1 1 1 0 FAM176 family Glypican PF01153.19 ETO07026.1 - 0.034 13.0 4.1 0.039 12.8 4.1 1.1 1 0 0 1 1 1 0 Glypican HemX PF04375.14 ETO07026.1 - 0.04 13.2 3.4 0.052 12.8 3.4 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase CLN3 PF02487.17 ETO07026.1 - 0.055 12.5 3.0 0.061 12.4 3.0 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4407 PF14362.6 ETO07026.1 - 0.065 12.6 1.4 0.078 12.3 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1640 PF07798.11 ETO07026.1 - 0.069 13.2 9.7 0.088 12.9 9.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Folate_carrier PF01770.18 ETO07026.1 - 0.11 11.3 1.6 0.14 10.8 1.6 1.2 1 0 0 1 1 1 0 Reduced folate carrier CPSF100_C PF13299.6 ETO07026.1 - 0.12 12.6 4.7 0.14 12.3 4.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 ETO07026.1 - 0.14 11.1 4.8 0.19 10.7 4.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3362 PF11842.8 ETO07026.1 - 0.14 12.5 6.6 0.27 11.6 6.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) RNA_pol_Rpc4 PF05132.14 ETO07026.1 - 0.15 12.5 3.9 0.17 12.3 3.9 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Connexin PF00029.19 ETO07026.1 - 0.16 11.7 3.9 0.19 11.5 3.9 1.3 1 0 0 1 1 1 0 Connexin RPN2_C PF18004.1 ETO07026.1 - 0.19 11.6 10.9 0.23 11.4 10.9 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CENP-H PF05837.12 ETO07026.1 - 0.22 11.9 7.9 0.34 11.3 7.9 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) RR_TM4-6 PF06459.12 ETO07026.1 - 0.23 11.2 9.7 0.25 11.1 9.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NARP1 PF12569.8 ETO07026.1 - 0.24 10.3 11.1 0.3 9.9 11.1 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Pox_Ag35 PF03286.14 ETO07026.1 - 0.4 10.4 12.2 0.55 10.0 12.2 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Exonuc_VII_L PF02601.15 ETO07026.1 - 0.6 9.6 6.0 0.71 9.4 6.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pox_RNA_Pol_19 PF05320.12 ETO07026.1 - 0.67 9.9 6.7 0.96 9.4 6.7 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Neur_chan_memb PF02932.16 ETO07026.1 - 0.71 9.9 3.8 0.83 9.7 3.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO07026.1 - 0.93 8.2 5.4 1.1 8.0 5.4 1.1 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.5 ETO07026.1 - 1.2 8.9 12.9 1.9 8.3 12.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus OrfB_IS605 PF01385.19 ETO07026.1 - 1.3 9.3 7.2 4.2 7.6 7.2 1.8 1 1 0 1 1 1 0 Probable transposase Ureide_permease PF07168.11 ETO07026.1 - 2.2 6.9 4.2 2.7 6.7 4.2 1.1 1 0 0 1 1 1 0 Ureide permease Sec62 PF03839.16 ETO07026.1 - 3.3 7.2 9.1 4.1 6.9 9.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 O-antigen_lig PF13425.6 ETO07026.1 - 7.3 5.2 6.1 8.2 5.1 6.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF1910 PF08928.10 ETO07027.1 - 0.17 11.9 5.5 1.3 9.0 5.5 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) MA3 PF02847.17 ETO07027.1 - 0.26 11.3 3.1 5.2 7.1 0.1 3.0 3 0 0 3 3 3 0 MA3 domain Pox_Ag35 PF03286.14 ETO07027.1 - 3.4 7.4 13.0 7.2 6.4 13.0 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MRI PF15325.6 ETO07027.1 - 4.1 8.5 5.6 12 7.1 4.7 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection RNase_H PF00075.24 ETO07028.1 - 0.014 15.6 0.0 0.018 15.2 0.0 1.4 1 1 0 1 1 1 0 RNase H WD40 PF00400.32 ETO07029.1 - 1.6e-54 180.6 17.0 2.7e-09 37.5 0.0 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07029.1 - 1.2e-16 60.7 4.8 0.0015 18.8 0.0 6.2 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07029.1 - 1e-11 44.4 0.2 0.2 10.6 0.0 5.5 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO07029.1 - 3.9e-07 29.7 6.0 0.19 11.0 0.0 4.5 1 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO07029.1 - 7.1e-05 21.6 10.1 1 7.9 0.0 4.9 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO07029.1 - 0.00025 21.2 0.1 2.6 8.5 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Nucleoporin_N PF08801.11 ETO07029.1 - 0.00056 18.8 6.7 0.46 9.2 0.1 3.7 2 1 0 3 3 3 2 Nup133 N terminal like Kelch_1 PF01344.25 ETO07029.1 - 0.0063 16.1 0.6 1.4 8.6 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO07029.1 - 0.0093 15.9 3.4 4 7.5 0.0 4.5 6 0 0 6 6 6 1 Kelch motif N_Asn_amidohyd PF14736.6 ETO07029.1 - 0.013 14.6 0.0 1.6 7.9 0.0 2.5 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Nbs1_C PF08599.10 ETO07029.1 - 0.15 12.3 0.2 0.37 11.0 0.2 1.6 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 Methyltransf_28 PF02636.17 ETO07030.1 - 1.1e-35 123.6 0.0 2e-35 122.7 0.0 1.4 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase SRP-alpha_N PF04086.13 ETO07030.1 - 0.14 12.1 0.5 0.2 11.5 0.5 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal UCH_C PF18031.1 ETO07031.1 - 6.2e-11 42.0 1.1 6.2e-11 42.0 1.1 2.4 2 1 0 2 2 1 1 Ubiquitin carboxyl-terminal hydrolases MscS_TM PF12794.7 ETO07031.1 - 0.0044 15.9 0.0 0.0044 15.9 0.0 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 Rtf2 PF04641.12 ETO07031.1 - 0.0082 15.5 4.7 0.0093 15.4 4.7 1.0 1 0 0 1 1 1 1 Rtf2 RING-finger Peroxin-13_N PF04088.13 ETO07031.1 - 0.018 15.4 0.7 0.025 14.9 0.7 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Connexin PF00029.19 ETO07031.1 - 0.021 14.6 0.8 0.026 14.3 0.8 1.1 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.9 ETO07031.1 - 0.065 13.3 1.4 0.086 12.9 1.4 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein LPP20 PF02169.16 ETO07031.1 - 0.078 13.3 0.2 0.097 13.0 0.2 1.2 1 0 0 1 1 1 0 LPP20 lipoprotein FAM176 PF14851.6 ETO07031.1 - 0.078 12.6 1.5 0.098 12.3 1.5 1.1 1 0 0 1 1 1 0 FAM176 family DUF3899 PF13038.6 ETO07031.1 - 0.12 12.9 0.3 0.17 12.4 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) LicD PF04991.13 ETO07031.1 - 0.17 12.0 6.1 0.19 11.9 6.1 1.0 1 0 0 1 1 1 0 LicD family Peptidase_S49_N PF08496.10 ETO07031.1 - 0.61 10.1 9.5 0.74 9.9 9.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal MAP17 PF15807.5 ETO07031.1 - 0.95 9.7 5.9 1.3 9.3 5.9 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF1682 PF07946.14 ETO07031.1 - 1.2 8.2 12.4 1.8 7.7 12.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Atypical_Card PF18461.1 ETO07032.1 - 0.03 14.5 0.4 0.41 10.9 0.4 3.1 1 0 0 1 1 1 0 Atypical caspase recruitment domain CUE PF02845.16 ETO07033.1 - 0.012 15.3 0.1 0.028 14.1 0.1 1.7 1 0 0 1 1 1 0 CUE domain T4SS PF07996.11 ETO07033.1 - 0.13 12.7 1.0 0.19 12.1 1.0 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins WD40 PF00400.32 ETO07034.1 - 3.5e-15 56.1 11.4 7.2e-05 23.5 0.0 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07034.1 - 0.00023 19.9 2.5 0.043 12.4 0.8 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07034.1 - 0.00033 20.9 0.3 0.53 10.6 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07034.1 - 0.0017 17.7 2.0 0.042 13.2 0.2 2.8 1 1 1 2 2 2 1 WD40-like domain DUF4922 PF16269.5 ETO07035.1 - 0.024 14.4 0.0 0.037 13.8 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4922) MRP-L27 PF09809.9 ETO07035.1 - 0.11 12.3 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein L27 Kelch_4 PF13418.6 ETO07036.1 - 0.00019 21.4 1.1 0.0011 18.9 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO07036.1 - 0.0045 17.3 0.1 0.018 15.3 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain DUF4905 PF16248.5 ETO07036.1 - 0.013 15.4 1.9 0.17 11.8 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4905) Kelch_1 PF01344.25 ETO07036.1 - 0.016 14.8 0.2 0.038 13.6 0.2 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_2 PF07646.15 ETO07036.1 - 0.027 14.5 0.1 0.07 13.1 0.1 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 ETO07036.1 - 0.032 14.2 0.2 0.07 13.1 0.2 1.6 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 ETO07036.1 - 0.088 13.1 0.5 0.37 11.1 0.5 2.1 1 0 0 1 1 1 0 Kelch motif tRNA-synt_1c PF00749.21 ETO07037.1 - 1.6e-38 132.4 0.0 1.6e-38 132.4 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1e PF01406.19 ETO07037.1 - 0.0063 15.9 0.1 0.0063 15.9 0.1 2.3 2 1 1 3 3 3 1 tRNA synthetases class I (C) catalytic domain JHY PF15261.6 ETO07038.1 - 4.1e-05 24.3 16.0 0.015 16.0 0.1 3.2 3 0 0 3 3 3 3 Jhy protein DUF4554 PF15091.6 ETO07038.1 - 0.007 15.3 0.1 0.007 15.3 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF4554) Bin3 PF06859.12 ETO07039.1 - 7.7e-12 45.8 0.5 1.3e-08 35.4 0.0 2.1 1 1 1 2 2 2 2 Bicoid-interacting protein 3 (Bin3) FAM176 PF14851.6 ETO07039.1 - 0.028 14.1 0.2 0.031 13.9 0.2 1.2 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ETO07039.1 - 0.2 12.0 6.0 0.1 13.0 4.0 1.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ETRAMP PF09716.10 ETO07039.1 - 5.8 7.1 7.3 12 6.0 7.3 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) PRIMA1 PF16101.5 ETO07040.1 - 1.4 8.9 4.7 4.5 7.3 4.7 1.8 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 dCMP_cyt_deam_1 PF00383.23 ETO07043.1 - 6.1e-27 93.5 0.6 1.2e-26 92.5 0.0 1.8 2 1 0 2 2 2 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETO07043.1 - 2.2e-14 53.4 0.0 3.9e-14 52.6 0.0 1.4 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ETO07043.1 - 0.047 13.8 2.4 0.18 11.9 0.1 2.2 2 0 0 2 2 2 0 Secreted Novel AID/APOBEC-like Deaminase 4 zf-NPL4 PF05020.15 ETO07045.1 - 0.035 14.3 0.3 0.051 13.7 0.3 1.3 1 0 0 1 1 1 0 NPL4 family, putative zinc binding region YebO PF13974.6 ETO07045.1 - 0.079 13.0 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 YebO-like protein TPR_12 PF13424.6 ETO07046.1 - 3e-38 129.9 2.8 2e-12 47.2 0.0 5.9 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07046.1 - 2.9e-25 87.0 31.1 0.0001 22.0 0.0 9.0 8 1 1 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07046.1 - 9.8e-23 78.4 24.9 0.00039 20.3 0.0 9.0 7 2 2 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07046.1 - 1e-15 56.6 26.4 0.00027 20.9 0.0 7.7 7 1 1 8 8 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07046.1 - 1.1e-15 56.9 5.2 0.00091 19.0 0.0 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07046.1 - 4e-14 51.5 14.2 0.00037 20.3 0.0 7.6 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO07046.1 - 6.3e-09 35.9 11.4 5.9 7.8 0.4 8.0 8 1 1 9 9 9 2 Tetratricopeptide repeat SNAP PF14938.6 ETO07046.1 - 9.4e-08 31.8 19.4 0.0002 20.9 1.5 3.9 1 1 2 4 4 4 3 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.9 ETO07046.1 - 3.6e-07 29.5 1.2 0.85 9.1 0.0 5.8 6 0 0 6 6 6 2 SHNi-TPR TPR_11 PF13414.6 ETO07046.1 - 9e-06 25.3 15.4 0.54 10.0 0.2 7.3 4 2 4 8 8 8 3 TPR repeat TPR_14 PF13428.6 ETO07046.1 - 4.5e-05 23.9 0.0 4.3 8.4 0.0 5.8 6 1 1 7 7 6 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO07046.1 - 5.8e-05 23.2 18.1 0.56 10.7 0.4 7.1 9 0 0 9 9 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO07046.1 - 0.0008 18.9 0.0 0.65 9.3 0.0 2.7 1 1 2 3 3 3 3 MalT-like TPR region TPR_16 PF13432.6 ETO07046.1 - 0.0015 19.1 0.1 16 6.3 0.0 5.1 6 1 1 7 7 5 0 Tetratricopeptide repeat ANAPC5 PF12862.7 ETO07046.1 - 0.0044 17.0 5.9 0.53 10.4 0.1 3.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 5 ANAPC3 PF12895.7 ETO07046.1 - 0.0096 16.1 27.3 0.017 15.4 1.5 5.9 2 1 5 7 7 7 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF1824 PF08854.10 ETO07046.1 - 0.013 15.4 0.0 0.098 12.6 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1824) SLT PF01464.20 ETO07046.1 - 0.03 14.0 2.0 5.1 6.8 0.1 2.9 3 0 0 3 3 3 0 Transglycosylase SLT domain RHD_DNA_bind PF00554.22 ETO07046.1 - 0.03 14.3 0.1 0.29 11.1 0.0 2.3 3 0 0 3 3 2 0 Rel homology DNA-binding domain Sel1 PF08238.12 ETO07046.1 - 0.032 14.9 4.9 7.1 7.5 0.0 4.3 4 1 0 4 4 3 0 Sel1 repeat SPO22 PF08631.10 ETO07046.1 - 0.034 13.6 4.9 0.23 10.9 0.0 3.6 2 1 2 4 4 4 0 Meiosis protein SPO22/ZIP4 like Elf1 PF05129.13 ETO07046.1 - 0.053 13.6 0.4 37 4.4 0.1 3.3 3 0 0 3 3 3 0 Transcription elongation factor Elf1 like DUF5118 PF17162.4 ETO07046.1 - 0.12 12.2 0.3 0.71 9.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5118) Alpha_Helical PF18489.1 ETO07046.1 - 0.17 12.0 1.3 4.1 7.6 0.0 2.8 2 1 0 2 2 2 0 Alpha helical domain MIT PF04212.18 ETO07046.1 - 0.33 11.0 9.5 17 5.6 0.1 5.4 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain NSF PF02071.20 ETO07046.1 - 0.45 11.5 5.9 22 6.4 0.1 5.1 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat Abhydrolase_3 PF07859.13 ETO07047.1 - 0.23 11.3 0.0 0.33 10.8 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold DUF1794 PF08768.11 ETO07048.1 - 1e-30 106.7 0.0 1.7e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1794) ALMT PF11744.8 ETO07049.1 - 1.5 7.5 5.8 2.2 7.0 5.8 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter RMMBL PF07521.12 ETO07051.1 - 5.9e-12 45.3 0.2 1.9e-11 43.7 0.0 2.0 2 0 0 2 2 2 1 Zn-dependent metallo-hydrolase RNA specificity domain Beta-Casp PF10996.8 ETO07051.1 - 7.1e-08 32.7 0.0 2e-07 31.3 0.0 1.8 2 0 0 2 2 2 1 Beta-Casp domain XRN_M PF17846.1 ETO07052.1 - 7.7e-05 21.8 1.4 0.00015 20.8 0.0 1.9 2 0 0 2 2 2 1 Xrn1 helical domain Cytidylate_kin2 PF13189.6 ETO07056.1 - 0.058 13.5 1.3 0.17 12.0 0.1 2.2 2 0 0 2 2 2 0 Cytidylate kinase-like family DUF585 PF04522.12 ETO07056.1 - 0.11 12.2 0.2 0.25 11.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF585) SAP PF02037.27 ETO07057.1 - 4.6e-10 39.0 0.3 1e-09 37.9 0.3 1.6 1 0 0 1 1 1 1 SAP domain XPG_N PF00752.17 ETO07058.1 - 3.1e-23 82.2 0.1 6e-23 81.2 0.1 1.5 1 0 0 1 1 1 1 XPG N-terminal domain XPG_I PF00867.18 ETO07058.1 - 3.1e-14 53.1 1.6 3.8e-14 52.8 0.1 1.9 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 ETO07058.1 - 6.9e-09 36.2 0.3 6.9e-08 33.0 0.0 2.6 3 0 0 3 3 3 1 5'-3' exonuclease, C-terminal SAM fold ARL2_Bind_BART PF11527.8 ETO07058.1 - 0.17 12.0 2.0 4.3 7.5 0.1 2.4 1 1 1 2 2 2 0 The ARF-like 2 binding protein BART RSN1_TM PF13967.6 ETO07060.1 - 1.5e-25 89.7 0.3 2.8e-25 88.9 0.3 1.5 1 1 0 1 1 1 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ETO07060.1 - 0.00027 21.2 0.3 0.0016 18.7 0.0 2.2 2 0 0 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter PIG-P PF08510.12 ETO07060.1 - 1.7 8.6 5.9 1.5 8.8 0.0 2.6 3 0 0 3 3 3 0 PIG-P Aldo_ket_red PF00248.21 ETO07061.1 - 1.5e-24 86.8 0.0 1.8e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family AveC_like PF17198.4 ETO07061.1 - 0.077 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Spirocyclase AveC-like zf-C3HC4_3 PF13920.6 ETO07062.1 - 6.4e-12 45.1 9.9 1.3e-11 44.2 9.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO07062.1 - 3.1e-07 30.2 10.8 7.7e-07 28.9 10.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SAM_1 PF00536.30 ETO07062.1 - 0.0007 20.0 0.3 0.0013 19.1 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-RING_5 PF14634.6 ETO07062.1 - 0.0024 17.8 10.2 0.0054 16.7 10.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain UBA_2 PF08587.11 ETO07062.1 - 0.011 15.8 0.1 6.5 7.0 0.0 2.9 2 0 0 2 2 2 0 Ubiquitin associated domain (UBA) zf-RING_2 PF13639.6 ETO07062.1 - 0.068 13.5 12.8 0.095 13.0 11.4 2.1 2 0 0 2 2 2 0 Ring finger domain ArAE_2 PF10334.9 ETO07062.1 - 0.094 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Aromatic acid exporter family member 2 DUF1645 PF07816.11 ETO07062.1 - 0.36 11.4 5.1 0.054 14.1 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) zf-C3HC4 PF00097.25 ETO07062.1 - 3.5 7.6 13.2 10 6.1 13.2 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1612 PF07756.12 ETO07064.1 - 0.082 13.2 0.5 0.11 12.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) Baculo_p24 PF05073.12 ETO07064.1 - 0.17 11.7 5.8 0.084 12.6 2.9 1.9 1 1 1 2 2 2 0 Baculovirus P24 capsid protein PH_12 PF16457.5 ETO07065.1 - 0.014 15.9 0.0 0.018 15.6 0.0 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain AAA_7 PF12775.7 ETO07066.1 - 0.0004 19.9 0.0 0.00067 19.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETO07066.1 - 0.00061 19.7 0.0 0.00084 19.3 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_11 PF13086.6 ETO07066.1 - 0.00073 19.4 1.2 0.0065 16.3 0.0 2.1 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO07066.1 - 0.00079 19.9 0.4 0.0018 18.8 0.0 1.7 2 1 0 2 2 2 1 ABC transporter T2SSE PF00437.20 ETO07066.1 - 0.0009 18.4 0.0 0.00099 18.2 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 ETO07066.1 - 0.001 19.1 0.0 0.0018 18.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO07066.1 - 0.0018 18.7 0.0 0.0031 17.9 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 ETO07066.1 - 0.0068 16.8 0.0 0.01 16.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain IstB_IS21 PF01695.17 ETO07066.1 - 0.0092 15.7 0.0 0.013 15.2 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein ATPase_2 PF01637.18 ETO07066.1 - 0.01 15.8 0.0 0.017 15.1 0.0 1.3 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ETO07066.1 - 0.012 15.8 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 ETO07066.1 - 0.019 15.0 0.7 0.065 13.2 0.0 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Zeta_toxin PF06414.12 ETO07066.1 - 0.021 14.1 0.1 0.048 12.9 0.0 1.6 2 0 0 2 2 2 0 Zeta toxin Rad17 PF03215.15 ETO07066.1 - 0.021 14.7 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain AAA PF00004.29 ETO07066.1 - 0.032 14.7 0.0 0.079 13.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ETO07066.1 - 0.032 14.4 0.3 0.16 12.1 0.0 2.1 3 0 0 3 3 3 0 AAA domain AAA_18 PF13238.6 ETO07066.1 - 0.042 14.4 0.0 0.087 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO07066.1 - 0.073 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 NACHT domain AAA_5 PF07728.14 ETO07066.1 - 0.075 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 ETO07066.1 - 0.087 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Cytidylate_kin PF02224.18 ETO07066.1 - 0.094 12.4 0.0 0.39 10.4 0.0 1.9 1 1 1 2 2 2 0 Cytidylate kinase ERK-JNK_inhib PF15002.6 ETO07066.1 - 0.41 10.3 3.8 0.12 12.0 0.5 1.8 2 0 0 2 2 2 0 ERK and JNK pathways, inhibitor DUF599 PF04654.12 ETO07067.1 - 0.057 12.8 0.1 0.07 12.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF599 Siah-Interact_N PF09032.11 ETO07068.1 - 0.037 14.3 0.4 0.056 13.8 0.4 1.2 1 0 0 1 1 1 0 Siah interacting protein, N terminal PUB PF09409.10 ETO07069.1 - 1.6e-06 27.9 0.5 4.8e-06 26.4 0.4 1.8 1 1 1 2 2 2 1 PUB domain ParD_antitoxin PF03693.14 ETO07069.1 - 0.0095 16.3 0.0 0.021 15.2 0.0 1.5 1 0 0 1 1 1 1 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH Kelch_5 PF13854.6 ETO07070.1 - 0.00085 19.2 0.0 0.094 12.7 0.1 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO07070.1 - 0.001 19.3 0.1 0.45 10.9 0.0 3.1 3 0 0 3 3 3 1 Kelch motif DUF2371 PF10177.9 ETO07070.1 - 0.1 12.7 0.1 0.18 11.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2371) Kelch_1 PF01344.25 ETO07070.1 - 0.16 11.6 0.0 1.2 8.8 0.0 2.4 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO07070.1 - 0.18 11.9 0.3 1.5 8.9 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain WD40 PF00400.32 ETO07071.1 - 2.7e-122 395.1 57.7 4.1e-10 40.1 0.1 15.6 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07071.1 - 1.2e-24 86.4 11.8 0.054 13.8 0.0 12.3 2 2 10 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07071.1 - 5.2e-21 75.3 7.3 0.0073 15.7 0.0 8.0 4 2 4 8 8 8 6 WD40-like domain Nup160 PF11715.8 ETO07071.1 - 3.6e-12 45.7 22.1 0.088 11.4 0.0 10.5 3 3 6 10 10 10 5 Nucleoporin Nup120/160 NACHT PF05729.12 ETO07071.1 - 1.3e-09 38.2 0.0 4.2e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO07071.1 - 2.2e-07 30.4 2.5 5.1e-07 29.2 2.5 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO07071.1 - 2.4e-07 30.8 1.9 0.45 10.7 0.0 7.8 7 3 3 10 10 9 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO07071.1 - 4.2e-05 22.3 6.1 5.1 5.5 0.0 5.9 2 1 4 7 7 7 1 Cytochrome D1 heme domain AAA_18 PF13238.6 ETO07071.1 - 0.00062 20.3 0.0 0.0027 18.2 0.0 2.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO07071.1 - 0.0016 18.7 0.0 0.0051 17.1 0.0 1.9 1 0 0 1 1 1 1 AAA domain HARP PF07443.13 ETO07071.1 - 0.0028 17.3 1.2 0.19 11.4 0.2 4.6 5 0 0 5 5 5 1 HepA-related protein (HARP) BBS2_Mid PF14783.6 ETO07071.1 - 0.0046 17.0 2.4 3 7.9 0.0 6.5 8 1 0 8 8 6 1 Ciliary BBSome complex subunit 2, middle region Pentapeptide_4 PF13599.6 ETO07071.1 - 0.0079 16.3 0.1 0.025 14.7 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Gmad1 PF10647.9 ETO07071.1 - 0.016 15.0 0.0 1.2 8.9 0.0 3.3 2 2 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain Pentapeptide_3 PF13576.6 ETO07071.1 - 0.016 15.3 0.2 0.06 13.5 0.2 2.0 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) PQQ_2 PF13360.6 ETO07071.1 - 0.041 13.5 2.6 4.1 6.9 0.0 3.3 1 1 2 3 3 3 0 PQQ-like domain ATP_bind_2 PF03668.15 ETO07071.1 - 0.095 12.0 0.1 0.22 10.8 0.0 1.6 2 0 0 2 2 2 0 P-loop ATPase protein family PD40 PF07676.12 ETO07071.1 - 0.12 12.4 24.8 10 6.2 0.1 8.9 11 0 0 11 11 9 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO07071.1 - 1.6 8.8 10.9 23 5.1 0.0 6.9 4 1 4 8 8 8 0 Family of unknown function (DUF5570) CUE PF02845.16 ETO07072.1 - 0.0011 18.6 0.0 0.002 17.8 0.0 1.4 1 0 0 1 1 1 1 CUE domain VASt PF16016.5 ETO07073.1 - 8.7e-21 74.9 2.9 8.7e-21 74.9 2.9 1.9 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain CDC45 PF02724.14 ETO07073.1 - 0.046 12.0 4.2 0.064 11.6 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein ASFV_J13L PF05568.11 ETO07073.1 - 0.19 11.5 0.0 0.35 10.6 0.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein PCM1_C PF15717.5 ETO07073.1 - 0.64 8.6 9.1 0.94 8.1 9.1 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Striatin PF08232.12 ETO07073.1 - 2 9.0 10.8 3.6 8.2 10.8 1.3 1 0 0 1 1 1 0 Striatin family NARP1 PF12569.8 ETO07073.1 - 3.4 6.5 15.0 4.9 6.0 15.0 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 OAD_gamma PF04277.13 ETO07075.1 - 2 9.1 5.8 14 6.4 0.3 3.4 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain TLD PF07534.16 ETO07077.1 - 0.038 14.2 0.1 0.063 13.5 0.1 1.4 1 0 0 1 1 1 0 TLD WD40 PF00400.32 ETO07079.1 - 5.6e-06 27.0 5.0 6.5e-05 23.6 0.3 3.7 3 2 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO07079.1 - 0.089 11.4 0.3 0.54 8.8 0.1 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Fmp27_SW PF10305.9 ETO07080.1 - 0.19 12.5 4.4 2.2 9.0 0.4 2.3 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF840 PF05801.11 ETO07083.1 - 0.026 14.6 0.4 0.033 14.3 0.4 1.1 1 0 0 1 1 1 0 Lagovirus protein of unknown function (DUF840) RPEL PF02755.15 ETO07085.1 - 8.4e-11 41.2 19.6 0.00059 19.5 1.6 5.7 5 0 0 5 5 5 4 RPEL repeat DUF2203 PF09969.9 ETO07085.1 - 0.2 12.4 6.9 0.32 11.7 0.0 3.5 3 1 1 4 4 4 0 Uncharacterized conserved protein (DUF2203) RPEL PF02755.15 ETO07086.1 - 5.7e-05 22.7 10.9 0.044 13.5 0.0 4.8 6 0 0 6 6 6 2 RPEL repeat SVIP PF15811.5 ETO07086.1 - 0.044 14.2 0.9 0.044 14.2 0.9 5.0 4 2 1 5 5 5 0 Small VCP/p97-interacting protein RVT_1 PF00078.27 ETO07087.1 - 5e-10 39.3 1.4 3.1e-08 33.4 0.2 2.7 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 ETO07087.1 - 0.00019 21.4 0.5 0.00047 20.1 0.1 1.9 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase EIF_2_alpha PF07541.12 ETO07087.1 - 0.052 13.7 0.2 0.2 11.8 0.2 2.0 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Fib_alpha PF08702.10 ETO07087.1 - 7.1 6.8 12.3 0.19 11.9 1.2 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DDE_3 PF13358.6 ETO07088.1 - 4.6e-13 49.1 0.4 4.8e-13 49.1 0.4 1.0 1 0 0 1 1 1 1 DDE superfamily endonuclease PIN7 PF18475.1 ETO07090.1 - 0.014 16.0 0.2 0.042 14.5 0.2 1.9 1 0 0 1 1 1 0 PIN domain Peptidase_S49_N PF08496.10 ETO07090.1 - 0.097 12.7 5.0 0.24 11.5 5.0 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Sigma_reg_C PF13791.6 ETO07090.1 - 0.39 10.9 9.5 6.2 7.0 4.3 2.4 2 1 0 2 2 2 0 Sigma factor regulator C-terminal DUF1863 PF08937.11 ETO07090.1 - 1.6 9.1 10.6 1.2 9.5 5.5 2.7 3 0 0 3 3 3 0 MTH538 TIR-like domain (DUF1863) RVT_1 PF00078.27 ETO07091.1 - 4.5e-05 23.1 0.3 0.00064 19.3 0.3 2.4 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4407 PF14362.6 ETO07091.1 - 3.1 7.1 7.9 5.6 6.2 7.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ETO07091.1 - 3.8 7.7 22.8 0.74 10.0 7.7 3.2 3 1 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 ETO07091.1 - 8 5.7 13.0 0.23 10.8 4.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Mad3_BUB1_II PF08171.11 ETO07092.1 - 0.055 13.6 1.2 0.055 13.6 1.2 1.9 1 1 0 2 2 2 0 Mad3/BUB1 homology region 2 HEPN_Toprim_N PF18871.1 ETO07092.1 - 0.068 13.1 1.9 0.1 12.5 1.7 1.3 1 1 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 ERM PF00769.19 ETO07093.1 - 0.0051 16.7 32.1 0.0062 16.4 32.1 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Sec34 PF04136.15 ETO07093.1 - 0.0069 16.3 18.9 0.081 12.8 7.8 2.1 1 1 1 2 2 2 2 Sec34-like family APG6_N PF17675.1 ETO07093.1 - 0.0075 16.8 37.6 0.019 15.5 19.7 2.1 1 1 1 2 2 2 1 Apg6 coiled-coil region DUF4164 PF13747.6 ETO07093.1 - 0.0097 16.2 19.7 0.068 13.5 7.2 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4164) RasGAP_C PF03836.15 ETO07093.1 - 0.021 15.0 21.4 0.34 11.1 11.2 2.1 1 1 1 2 2 2 0 RasGAP C-terminus Tropomyosin PF00261.20 ETO07093.1 - 0.026 13.9 31.1 0.033 13.6 31.1 1.1 1 0 0 1 1 1 0 Tropomyosin DUF1664 PF07889.12 ETO07093.1 - 0.038 14.0 20.9 0.1 12.6 6.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 ETO07093.1 - 0.084 12.2 25.6 0.29 10.4 13.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 ETO07093.1 - 0.094 11.6 29.0 0.15 10.9 29.0 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein SHE3 PF17078.5 ETO07093.1 - 0.11 12.2 24.8 0.27 10.9 24.8 1.5 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 EzrA PF06160.12 ETO07093.1 - 0.14 10.3 29.1 0.14 10.3 14.4 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Baculo_PEP_C PF04513.12 ETO07093.1 - 0.15 12.1 4.5 0.95 9.5 3.8 2.1 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Leu_zip PF15294.6 ETO07093.1 - 0.16 11.5 28.0 0.054 13.0 9.7 2.1 1 1 1 2 2 2 0 Leucine zipper Prefoldin_2 PF01920.20 ETO07093.1 - 0.21 11.6 41.3 0.49 10.4 12.4 4.0 1 1 3 4 4 4 0 Prefoldin subunit ADIP PF11559.8 ETO07093.1 - 0.21 11.7 27.8 0.086 12.9 14.6 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding TACC_C PF05010.14 ETO07093.1 - 0.23 11.2 33.5 0.38 10.5 33.5 1.4 1 1 0 1 1 1 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF2951 PF11166.8 ETO07093.1 - 0.23 11.7 21.2 0.037 14.3 12.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2951) AAA_13 PF13166.6 ETO07093.1 - 0.28 9.8 20.2 0.34 9.5 20.2 1.1 1 0 0 1 1 1 0 AAA domain CENP-F_leu_zip PF10473.9 ETO07093.1 - 0.35 10.9 38.2 1.6 8.7 20.9 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Herpes_UL6 PF01763.16 ETO07093.1 - 0.37 9.2 14.4 0.47 8.9 14.4 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like Atg14 PF10186.9 ETO07093.1 - 0.42 9.6 24.8 0.36 9.9 21.6 1.8 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF677 PF05055.12 ETO07093.1 - 0.54 9.1 18.5 1.5 7.7 18.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF677) Cep57_CLD PF14073.6 ETO07093.1 - 0.55 10.2 30.3 0.7 9.9 30.3 1.0 1 0 0 1 1 1 0 Centrosome localisation domain of Cep57 DUF4200 PF13863.6 ETO07093.1 - 0.57 10.6 35.4 0.16 12.4 29.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) BLOC1_2 PF10046.9 ETO07093.1 - 0.68 10.3 21.6 1 9.7 10.7 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TMPIT PF07851.13 ETO07093.1 - 0.68 9.1 27.2 0.62 9.3 15.0 2.0 1 1 1 2 2 2 0 TMPIT-like protein DUF4337 PF14235.6 ETO07093.1 - 0.72 10.0 21.2 0.53 10.4 4.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Nsp1_C PF05064.13 ETO07093.1 - 0.8 9.5 21.7 0.71 9.7 8.7 2.4 1 1 1 2 2 2 0 Nsp1-like C-terminal region PI_PP_I PF18363.1 ETO07093.1 - 0.85 9.8 7.4 1.5 9.0 0.8 2.2 1 1 1 2 2 2 0 Phosphoinositide phosphatase insertion domain Tropomyosin_1 PF12718.7 ETO07093.1 - 0.87 9.7 36.5 2 8.6 18.0 2.1 1 1 1 2 2 2 0 Tropomyosin like DUF3584 PF12128.8 ETO07093.1 - 0.9 7.0 24.7 1.1 6.6 24.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TEX13 PF15186.6 ETO07093.1 - 0.94 9.2 20.1 1.2 8.8 9.3 2.1 1 1 1 2 2 2 0 Testis-expressed sequence 13 protein family FlxA PF14282.6 ETO07093.1 - 1.3 9.0 26.6 7.2 6.7 12.2 2.2 1 1 1 2 2 2 0 FlxA-like protein WDCP PF15390.6 ETO07093.1 - 1.4 7.2 17.4 1.6 7.0 17.4 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family OmpH PF03938.14 ETO07093.1 - 1.5 9.1 30.0 1.3 9.3 26.3 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) IFT57 PF10498.9 ETO07093.1 - 1.7 7.5 26.8 3.8 6.4 26.9 1.4 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Rho_Binding PF08912.11 ETO07093.1 - 1.7 9.5 33.2 1.1 10.1 9.6 3.2 1 1 2 3 3 3 0 Rho Binding Laminin_II PF06009.12 ETO07093.1 - 2.1 8.4 19.3 3.6 7.6 8.5 2.1 1 1 1 2 2 2 0 Laminin Domain II HAUS6_N PF14661.6 ETO07093.1 - 2.1 7.8 24.0 5.6 6.5 22.8 1.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus UPF0184 PF03670.13 ETO07093.1 - 2.2 8.7 9.6 2.2 8.7 2.1 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) HIP1_clath_bdg PF16515.5 ETO07093.1 - 2.4 8.8 29.9 2.7 8.7 15.9 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 ETO07093.1 - 2.5 7.4 14.2 3.2 7.0 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Occludin_ELL PF07303.13 ETO07093.1 - 2.8 8.7 20.3 1.8 9.3 4.4 2.3 1 1 1 2 2 2 0 Occludin homology domain Fib_alpha PF08702.10 ETO07093.1 - 2.8 8.1 21.9 23 5.2 21.9 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family THOC7 PF05615.13 ETO07093.1 - 3.5 7.9 26.6 2.6 8.3 19.2 2.4 1 1 1 2 2 2 0 Tho complex subunit 7 DUF2968 PF11180.8 ETO07093.1 - 3.7 7.1 19.0 7 6.2 7.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) Seryl_tRNA_N PF02403.22 ETO07093.1 - 3.9 7.8 30.1 0.78 10.0 17.2 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Bacillus_HBL PF05791.11 ETO07093.1 - 4 7.2 17.5 0.33 10.8 8.8 2.0 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) XhlA PF10779.9 ETO07093.1 - 4.1 7.7 22.9 1.2 9.4 9.4 3.1 1 1 3 4 4 4 0 Haemolysin XhlA Silic_transp PF03842.13 ETO07093.1 - 6.1 5.0 8.9 8.2 4.6 8.9 1.2 1 0 0 1 1 1 0 Silicon transporter Allexi_40kDa PF05549.11 ETO07093.1 - 6.3 6.2 17.2 2 7.9 7.6 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein Med4 PF10018.9 ETO07093.1 - 6.4 6.4 21.0 0.046 13.4 6.9 2.5 1 1 1 2 2 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF244 PF03112.14 ETO07093.1 - 6.4 6.6 12.8 2.2 8.1 2.3 2.2 1 1 1 2 2 2 0 Uncharacterized protein family (ORF7) DUF FlaC_arch PF05377.11 ETO07093.1 - 7.4 7.0 26.7 9.7 6.7 6.9 3.3 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Spectrin PF00435.21 ETO07093.1 - 7.8 7.0 23.6 15 6.1 3.9 2.9 1 1 1 2 2 2 0 Spectrin repeat Phage_GPO PF05929.11 ETO07093.1 - 8.2 6.0 19.4 14 5.2 19.4 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Lectin_N PF03954.14 ETO07093.1 - 9.1 6.0 17.5 5.3 6.8 2.3 2.5 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Glyco_transf_25 PF01755.17 ETO07094.1 - 0.041 13.7 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) NIF PF03031.18 ETO07095.1 - 1.2e-36 125.8 0.0 1.8e-36 125.3 0.0 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Helicase_RecD PF05127.14 ETO07095.1 - 0.007 16.2 2.3 0.011 15.6 2.3 1.3 1 0 0 1 1 1 1 Helicase RbsD_FucU PF05025.13 ETO07095.1 - 0.054 13.9 1.3 0.68 10.4 0.0 2.1 1 1 1 2 2 2 0 RbsD / FucU transport protein family Dicty_REP PF05086.12 ETO07095.1 - 0.073 11.0 7.6 0.089 10.8 7.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AIF_C PF14721.6 ETO07095.1 - 0.14 12.5 0.8 0.25 11.7 0.8 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Acid_phosphat_B PF03767.14 ETO07095.1 - 0.99 8.9 6.0 0.72 9.4 4.5 1.5 2 0 0 2 2 2 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Peptidase_M1 PF01433.20 ETO07096.1 - 5.5e-26 91.5 0.2 4.4e-17 62.4 0.0 2.0 1 1 1 2 2 2 2 Peptidase family M1 domain Stc1 PF12898.7 ETO07097.1 - 0.014 16.0 1.1 0.014 16.0 1.1 1.7 2 0 0 2 2 2 0 Stc1 domain AdenylateSensor PF16579.5 ETO07098.1 - 0.14 12.6 3.8 0.41 11.1 2.7 2.2 1 1 1 2 2 2 0 Adenylate sensor of SNF1-like protein kinase Fer4_16 PF13484.6 ETO07098.1 - 4.5 8.3 7.0 0.78 10.7 0.8 2.5 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain Tudor_4 PF18358.1 ETO07099.1 - 0.029 14.0 0.4 0.063 12.9 0.4 1.6 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain RP854 PF17460.2 ETO07099.1 - 0.15 11.8 1.2 0.24 11.2 1.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein RP854 KxDL PF10241.9 ETO07100.1 - 0.99 9.7 5.5 7.2 7.0 2.8 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein Spo7 PF03907.13 ETO07101.1 - 0.024 14.1 0.3 0.024 14.1 0.3 1.6 1 1 1 2 2 2 0 Spo7-like protein FtsJ PF01728.19 ETO07102.1 - 1.6e-30 106.5 0.0 3.4e-30 105.5 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase YcxB PF14317.6 ETO07102.1 - 0.018 14.7 0.0 0.059 13.1 0.0 1.9 1 0 0 1 1 1 0 YcxB-like protein Zip PF02535.22 ETO07102.1 - 0.044 13.0 0.8 0.079 12.2 0.8 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Dapper PF15268.6 ETO07102.1 - 0.17 10.8 5.3 0.27 10.0 5.3 1.2 1 0 0 1 1 1 0 Dapper S-methyl_trans PF02574.16 ETO07103.1 - 3.7e-49 167.9 0.2 2.5e-48 165.2 0.2 1.8 1 1 0 1 1 1 1 Homocysteine S-methyltransferase Kelch_5 PF13854.6 ETO07104.1 - 7.1e-05 22.7 0.7 0.39 10.8 0.6 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO07104.1 - 9.7e-05 21.9 1.9 0.13 11.8 0.4 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO07104.1 - 0.0027 17.9 4.5 0.087 13.1 0.0 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO07104.1 - 0.0061 16.5 3.2 2.6 8.2 0.0 3.8 4 0 0 4 4 4 2 Kelch motif RhoGAP-FF1 PF16512.5 ETO07104.1 - 0.046 14.4 0.4 0.14 12.8 0.4 1.8 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain WD40 PF00400.32 ETO07105.1 - 1.6e-08 35.0 1.0 6e-07 30.1 0.2 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat Fn3_assoc PF13287.6 ETO07105.1 - 0.06 13.5 0.2 0.46 10.7 0.0 2.0 1 1 1 2 2 2 0 Fn3 associated PRKG1_interact PF15898.5 ETO07106.1 - 1.2 10.0 10.5 0.1 13.5 5.2 1.9 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain FAM60A PF15396.6 ETO07107.1 - 0.00036 20.6 0.5 0.00054 20.0 0.5 1.2 1 0 0 1 1 1 1 Protein Family FAM60A Ldh_1_C PF02866.18 ETO07108.1 - 3.3e-16 59.7 0.0 4.1e-16 59.4 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain DUF4774 PF15999.5 ETO07108.1 - 0.024 14.5 0.1 8 6.4 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4774) TFIIF_alpha PF05793.12 ETO07112.1 - 0.45 9.0 40.0 0.89 8.1 40.0 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TMEM247 PF15444.6 ETO07112.1 - 0.48 10.4 0.0 0.48 10.4 0.0 3.8 4 0 0 4 4 4 0 Transmembrane protein 247 Oxidored_q3 PF00499.20 ETO07112.1 - 5.3 6.8 6.0 18 5.1 5.1 2.4 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 Clathrin PF00637.20 ETO07113.1 - 0.024 14.5 0.2 0.055 13.3 0.2 1.7 2 0 0 2 2 2 0 Region in Clathrin and VPS PPR PF01535.20 ETO07116.1 - 5.8e-11 41.9 6.0 0.0021 18.2 0.5 5.5 5 0 0 5 5 5 3 PPR repeat PPR_2 PF13041.6 ETO07116.1 - 6e-06 26.4 11.3 0.17 12.1 0.3 5.5 4 1 1 5 5 5 4 PPR repeat family PPR_3 PF13812.6 ETO07116.1 - 8.3e-06 25.8 3.3 0.0063 16.6 0.7 4.0 2 1 2 4 4 4 2 Pentatricopeptide repeat domain Smr PF01713.21 ETO07116.1 - 0.058 13.8 0.2 0.27 11.6 0.1 2.2 3 0 0 3 3 3 0 Smr domain WD40 PF00400.32 ETO07117.1 - 1.3e-16 60.6 13.9 1.4e-09 38.4 0.2 4.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Pentapeptide_4 PF13599.6 ETO07117.1 - 1.1e-05 25.5 0.3 4.3e-05 23.6 0.1 2.1 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) F-box-like PF12937.7 ETO07117.1 - 0.00063 19.6 0.1 0.0017 18.2 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO07117.1 - 0.0057 16.5 0.2 0.018 14.9 0.2 1.9 1 0 0 1 1 1 1 F-box domain Secretin_N_2 PF07655.13 ETO07117.1 - 0.73 10.4 25.7 1.1 9.9 1.1 2.9 3 0 0 3 3 3 0 Secretin N-terminal domain Phospholip_A2_1 PF00068.19 ETO07117.1 - 3.2 8.2 17.7 0.91 10.0 6.0 3.0 3 0 0 3 3 3 0 Phospholipase A2 Methyltransf_12 PF08242.12 ETO07117.1 - 4 8.2 11.7 48 4.8 0.1 3.9 3 0 0 3 3 3 0 Methyltransferase domain SUIM_assoc PF16619.5 ETO07117.1 - 4.1 7.6 7.9 0.19 11.8 0.7 2.6 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 DUF3492 PF11997.8 ETO07118.1 - 0.059 13.1 1.3 0.077 12.7 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Kei1 PF08552.11 ETO07118.1 - 0.081 12.8 0.3 0.11 12.4 0.3 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2254 PF10011.9 ETO07118.1 - 0.096 11.5 0.7 0.12 11.2 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) Presenilin PF01080.17 ETO07118.1 - 0.11 11.2 1.6 0.13 11.0 1.6 1.1 1 0 0 1 1 1 0 Presenilin PH PF00169.29 ETO07119.1 - 0.0016 19.0 2.2 1.2 9.7 0.3 2.7 2 1 0 2 2 2 2 PH domain CheF-arch PF04283.12 ETO07119.1 - 0.075 12.8 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 Chemotaxis signal transduction system protein F from archaea Cdd1 PF11731.8 ETO07124.1 - 0.0033 17.6 0.2 0.047 13.9 0.1 2.5 3 0 0 3 3 3 1 Pathogenicity locus CSTF2_hinge PF14327.6 ETO07124.1 - 0.0038 17.7 1.0 0.012 16.0 1.0 1.9 1 0 0 1 1 1 1 Hinge domain of cleavage stimulation factor subunit 2 Myosin_tail_1 PF01576.19 ETO07125.1 - 0.026 12.3 0.4 0.033 12.0 0.4 1.1 1 0 0 1 1 1 0 Myosin tail TipAS PF07739.13 ETO07125.1 - 0.097 13.2 0.2 0.53 10.9 0.2 2.2 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain PglD_N PF17836.1 ETO07125.1 - 0.29 11.8 1.5 28 5.4 0.1 3.0 2 1 1 3 3 3 0 PglD N-terminal domain GSHPx PF00255.19 ETO07126.1 - 6.7e-23 80.3 0.0 2.4e-22 78.5 0.0 1.8 1 1 0 1 1 1 1 Glutathione peroxidase Ccdc124 PF06244.12 ETO07128.1 - 0.075 13.6 0.3 0.11 13.1 0.3 1.4 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 124 /Oxs1 SNCAIP_SNCA_bd PF16700.5 ETO07129.1 - 0.012 15.3 0.7 0.059 13.1 0.1 2.5 2 1 0 2 2 2 0 Synphilin-1 alpha-Synuclein-binding domain DIT1_PvcA PF05141.12 ETO07129.1 - 0.076 12.5 7.3 0.032 13.7 4.9 1.5 1 1 1 2 2 2 0 Pyoverdine/dityrosine biosynthesis protein Transposase_24 PF03004.14 ETO07129.1 - 0.13 12.4 5.0 0.18 11.9 5.0 1.5 1 1 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) YtxH PF12732.7 ETO07129.1 - 0.14 12.7 1.9 1 9.9 1.9 2.4 1 1 0 1 1 1 0 YtxH-like protein SbsC_C PF18058.1 ETO07129.1 - 0.52 10.5 5.5 3.3 8.0 0.5 2.4 1 1 1 2 2 2 0 SbsC C-terminal domain Exonuc_VII_L PF02601.15 ETO07129.1 - 2.8 7.4 8.8 3.3 7.2 8.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit ALMT PF11744.8 ETO07129.1 - 6 5.6 11.2 9.4 4.9 11.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter BORCS7 PF16088.5 ETO07130.1 - 0.0092 16.2 0.3 1.4 9.2 0.0 2.9 2 0 0 2 2 2 2 BLOC-1-related complex sub-unit 7 ZIP4_domain PF18292.1 ETO07131.1 - 0.012 15.5 0.3 0.018 15.0 0.3 1.2 1 0 0 1 1 1 0 Zinc transporter ZIP4 domain MutS_IV PF05190.18 ETO07131.1 - 0.14 12.5 5.3 0.15 12.4 1.9 2.6 2 1 0 2 2 2 0 MutS family domain IV adh_short_C2 PF13561.6 ETO07132.1 - 3.1e-47 161.1 1.6 4.4e-45 154.0 0.0 2.5 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO07132.1 - 7.3e-39 133.2 0.5 9.7e-30 103.5 0.0 2.3 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 ETO07132.1 - 6.1e-06 26.3 0.1 0.0065 16.4 0.1 2.4 2 0 0 2 2 2 2 KR domain Vfa1 PF08432.10 ETO07132.1 - 0.012 16.0 17.6 0.012 16.0 17.6 3.1 2 1 1 3 3 2 0 AAA-ATPase Vps4-associated protein 1 Med15 PF09606.10 ETO07132.1 - 0.13 10.9 14.9 0.17 10.5 14.9 1.2 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal TFIIA PF03153.13 ETO07132.1 - 0.18 11.8 28.5 0.33 10.9 28.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SDA1 PF05285.12 ETO07132.1 - 0.46 9.9 47.0 1 8.7 15.4 2.2 2 0 0 2 2 2 0 SDA1 Mitofilin PF09731.9 ETO07132.1 - 0.76 8.5 36.4 0.05 12.5 8.1 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein DUF262 PF03235.14 ETO07132.1 - 1.3 9.1 15.6 0.03 14.5 3.2 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF262 Nop14 PF04147.12 ETO07132.1 - 1.6 6.9 42.3 0.03 12.6 14.7 2.1 2 0 0 2 2 2 0 Nop14-like family Presenilin PF01080.17 ETO07132.1 - 2.9 6.6 33.0 0.35 9.6 9.4 2.4 2 0 0 2 2 2 0 Presenilin DUF2757 PF10955.8 ETO07133.1 - 0.0025 18.0 1.7 0.0029 17.8 0.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2757) zinc_ribbon_2 PF13240.6 ETO07133.1 - 0.5 10.2 2.6 6.1 6.7 0.3 2.4 2 0 0 2 2 2 0 zinc-ribbon domain zf-LITAF-like PF10601.9 ETO07133.1 - 0.84 9.9 6.1 9.5 6.6 0.1 2.7 2 1 1 3 3 3 0 LITAF-like zinc ribbon domain zf-rbx1 PF12678.7 ETO07134.1 - 0.018 15.3 11.7 0.31 11.4 2.6 2.8 2 1 0 2 2 2 0 RING-H2 zinc finger domain Rad50_zn_hook PF04423.14 ETO07134.1 - 0.022 14.6 0.1 0.049 13.5 0.1 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C3HC4 PF00097.25 ETO07134.1 - 0.026 14.4 1.1 0.026 14.4 1.1 3.1 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO07134.1 - 0.032 14.0 3.3 0.032 14.0 3.3 3.4 4 0 0 4 4 4 0 RING-like zinc finger zf-RING_2 PF13639.6 ETO07134.1 - 0.044 14.1 18.1 0.48 10.8 2.4 3.4 2 2 0 2 2 2 0 Ring finger domain Lar_restr_allev PF14354.6 ETO07134.1 - 0.051 14.0 0.0 0.26 11.7 0.0 2.1 1 1 0 1 1 1 0 Restriction alleviation protein Lar zf-UDP PF14569.6 ETO07134.1 - 0.19 11.9 5.9 0.24 11.6 0.2 2.6 2 1 0 2 2 2 0 Zinc-binding RING-finger zf-ANAPC11 PF12861.7 ETO07134.1 - 0.41 10.7 9.6 3.6 7.7 1.1 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ETO07134.1 - 0.74 9.7 20.1 13 5.8 4.5 3.9 2 2 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zinc_ribbon_5 PF13719.6 ETO07134.1 - 0.94 9.3 7.4 9 6.1 0.1 3.6 3 0 0 3 3 3 0 zinc-ribbon domain DNA_RNApol_7kD PF03604.13 ETO07134.1 - 3.6 7.3 8.0 20 5.0 0.0 3.2 3 1 0 3 3 3 0 DNA directed RNA polymerase, 7 kDa subunit zf-RING_5 PF14634.6 ETO07134.1 - 6.7 6.8 16.3 3.6 7.6 6.5 3.0 2 1 0 2 2 2 0 zinc-RING finger domain SBF2 PF12335.8 ETO07137.1 - 0.025 14.2 3.0 0.03 13.9 3.0 1.3 1 0 0 1 1 1 0 Myotubularin protein DUF4166 PF13761.6 ETO07137.1 - 0.03 14.1 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4166) CdiI PF07262.11 ETO07138.1 - 0.019 14.7 0.1 0.037 13.8 0.1 1.5 1 0 0 1 1 1 0 CDI immunity protein AsmA_2 PF13502.6 ETO07138.1 - 0.061 12.8 0.2 0.083 12.4 0.2 1.1 1 0 0 1 1 1 0 AsmA-like C-terminal region HEM4 PF02602.15 ETO07138.1 - 0.072 12.4 0.1 0.11 11.8 0.1 1.2 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD HATPase_c_5 PF14501.6 ETO07138.1 - 0.085 12.8 0.2 0.085 12.8 0.2 2.2 2 1 0 2 2 2 0 GHKL domain DUF775 PF05603.12 ETO07139.1 - 9.1e-24 84.1 0.1 1.8e-22 79.9 0.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF775) PhnA_Zn_Ribbon PF08274.12 ETO07139.1 - 0.18 11.8 1.2 12 6.0 0.1 2.4 2 0 0 2 2 2 0 PhnA Zinc-Ribbon ABC2_membrane PF01061.24 ETO07140.1 - 3.2e-35 121.5 33.5 1.5e-34 119.3 33.5 1.8 1 1 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO07140.1 - 0.00012 21.3 21.0 0.00012 21.3 21.0 1.6 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ETO07140.1 - 1.7 7.9 22.9 0.13 11.5 13.4 2.3 1 1 1 2 2 2 0 ABC-2 family transporter protein TPR_12 PF13424.6 ETO07141.1 - 2.8e-62 207.0 12.5 3.9e-13 49.5 0.4 6.7 2 1 6 8 8 8 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07141.1 - 4.9e-39 131.1 0.0 1.4e-06 28.0 0.0 9.3 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07141.1 - 4.2e-22 77.0 40.7 6e-05 22.7 1.4 9.5 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07141.1 - 2.1e-20 71.1 33.7 5.7e-05 22.9 1.3 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07141.1 - 4.7e-20 70.1 11.5 2.2e-05 24.2 0.0 8.5 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07141.1 - 5e-17 60.6 45.0 4.1e-05 23.4 0.5 9.4 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO07141.1 - 3.2e-09 36.6 0.0 0.026 13.9 0.0 3.1 1 1 1 3 3 3 3 MalT-like TPR region TPR_14 PF13428.6 ETO07141.1 - 1.9e-08 34.4 0.1 1.8 9.6 0.0 6.9 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO07141.1 - 3.8e-07 30.7 0.2 2.5 8.8 0.0 5.5 5 2 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO07141.1 - 1.5e-05 25.0 9.1 12 6.6 0.0 7.6 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07141.1 - 0.00068 19.3 6.6 0.0053 16.4 0.5 7.2 8 1 1 9 9 9 2 TPR repeat TPR_19 PF14559.6 ETO07141.1 - 0.0055 17.2 0.0 14 6.3 0.0 4.8 6 0 0 6 6 6 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO07141.1 - 0.022 15.0 15.6 2.7 8.3 0.1 5.3 5 2 1 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 ETO07141.1 - 0.024 14.3 1.0 5.7 6.6 0.0 3.9 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain TPR_6 PF13174.6 ETO07141.1 - 0.026 15.1 12.5 5.8 7.8 0.1 8.0 9 0 0 9 9 9 0 Tetratricopeptide repeat DUF4810 PF16068.5 ETO07141.1 - 0.085 13.4 5.4 7.6 7.2 0.3 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4810) SHNi-TPR PF10516.9 ETO07141.1 - 1.3 8.5 6.6 34 4.0 0.0 4.6 6 0 0 6 6 6 0 SHNi-TPR MIT PF04212.18 ETO07141.1 - 3.5 7.8 17.0 46 4.2 0.2 6.6 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain CBF PF03914.17 ETO07143.1 - 3.3e-13 50.0 1.7 1.3e-10 41.5 0.1 4.2 3 3 1 4 4 4 2 CBF/Mak21 family YxiJ PF14176.6 ETO07145.1 - 0.016 15.7 0.7 0.025 15.1 0.7 1.3 1 0 0 1 1 1 0 YxiJ-like protein zf-RING_5 PF14634.6 ETO07147.1 - 9.5e-05 22.3 1.6 0.00025 20.9 1.6 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO07147.1 - 0.00043 20.3 1.3 0.00043 20.3 1.3 2.1 2 1 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO07147.1 - 0.0015 18.4 1.6 0.0035 17.2 1.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO07147.1 - 0.0016 18.3 0.5 0.0032 17.3 0.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO07147.1 - 0.0043 16.9 1.0 0.0087 15.9 1.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO07147.1 - 0.0079 16.5 0.8 0.015 15.7 0.8 1.5 1 0 0 1 1 1 1 Ring finger domain ABC_membrane PF00664.23 ETO07147.1 - 0.009 15.7 2.4 0.016 14.9 2.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region zf-C3HC4_4 PF15227.6 ETO07147.1 - 0.015 15.5 1.0 0.078 13.2 1.0 2.3 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Spt20 PF12090.8 ETO07147.1 - 0.027 14.1 19.9 0.027 14.1 19.9 1.2 1 0 0 1 1 1 0 Spt20 family DUF2722 PF10846.8 ETO07147.1 - 0.034 13.1 16.8 0.033 13.1 16.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) zf-RING_11 PF17123.5 ETO07147.1 - 0.064 13.0 0.2 0.064 13.0 0.2 1.8 2 0 0 2 2 1 0 RING-like zinc finger SpoIIP PF07454.11 ETO07147.1 - 0.079 12.4 3.0 0.09 12.2 3.0 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Neuregulin PF02158.15 ETO07147.1 - 0.12 11.7 4.5 0.12 11.7 4.5 1.0 1 0 0 1 1 1 0 Neuregulin intracellular region Med15 PF09606.10 ETO07147.1 - 0.58 8.8 17.3 0.55 8.9 17.3 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Suf PF05843.14 ETO07147.1 - 0.93 9.4 9.7 1 9.3 9.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TFIIA PF03153.13 ETO07147.1 - 1.2 9.1 18.5 1.2 9.1 18.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TMEM247 PF15444.6 ETO07147.1 - 9.6 6.2 13.5 13 5.7 13.5 1.3 1 0 0 1 1 1 0 Transmembrane protein 247 TPR_12 PF13424.6 ETO07148.1 - 1.4e-83 275.2 9.6 3.3e-21 75.4 0.1 5.2 3 1 3 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07148.1 - 1.4e-59 195.6 45.0 4.4e-10 38.9 1.0 8.7 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07148.1 - 2.8e-56 186.0 0.4 3.4e-07 29.9 0.0 8.7 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07148.1 - 4.9e-53 173.3 12.3 1.1e-07 31.4 0.2 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07148.1 - 1.1e-51 168.8 26.2 6.7e-08 32.1 0.4 8.4 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07148.1 - 3.9e-51 167.0 46.7 1.3e-08 34.4 0.9 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.6 ETO07148.1 - 1.3e-26 92.9 0.0 0.0017 19.0 0.0 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO07148.1 - 4.7e-25 86.1 12.6 0.016 15.5 0.0 9.6 10 1 0 10 10 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO07148.1 - 2.7e-21 74.4 0.0 0.07 14.0 0.0 8.2 6 2 2 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO07148.1 - 2.9e-20 71.5 7.0 0.017 15.8 0.0 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07148.1 - 3.7e-14 52.1 54.3 0.00063 19.4 3.3 11.7 9 4 3 12 12 12 5 TPR repeat TPR_3 PF07720.12 ETO07148.1 - 1e-12 47.8 28.0 0.068 13.2 0.3 7.8 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_19 PF14559.6 ETO07148.1 - 7e-12 45.7 3.5 0.00098 19.6 0.2 5.9 3 3 3 6 6 6 2 Tetratricopeptide repeat MIT PF04212.18 ETO07148.1 - 3.1e-10 39.9 24.7 0.059 13.4 0.2 6.9 8 0 0 8 8 7 3 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO07148.1 - 3.1e-08 33.3 8.7 0.39 11.1 0.1 7.5 8 0 0 8 8 7 1 PPR repeat DUF4810 PF16068.5 ETO07148.1 - 5e-07 30.2 12.6 0.62 10.7 0.0 6.2 6 2 1 7 7 5 2 Domain of unknown function (DUF4810) TPR_MalT PF17874.1 ETO07148.1 - 7e-06 25.6 0.0 0.1 11.9 0.0 2.6 1 1 0 2 2 2 2 MalT-like TPR region DUF5113 PF17140.4 ETO07148.1 - 4e-05 23.5 23.2 0.34 10.7 0.1 6.8 5 2 2 7 7 7 2 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO07148.1 - 4.8e-05 23.5 18.5 0.24 11.6 0.4 5.5 2 2 3 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETO07148.1 - 7.4e-05 22.8 0.0 0.04 14.1 0.0 3.6 2 1 2 4 4 4 1 Tetratricopeptide repeat RPN7 PF10602.9 ETO07148.1 - 0.00053 19.8 16.0 0.17 11.6 0.7 6.0 2 1 3 7 7 7 1 26S proteasome subunit RPN7 Sel1 PF08238.12 ETO07148.1 - 0.0029 18.2 13.7 20 6.0 0.1 6.8 8 0 0 8 8 6 0 Sel1 repeat UBA_6 PF18039.1 ETO07148.1 - 0.0053 16.6 1.3 2.3e+02 1.8 0.0 6.0 7 0 0 7 7 7 0 UBA-like domain Mob_Pre PF01076.19 ETO07148.1 - 0.016 15.1 13.2 0.078 12.8 1.1 3.3 1 1 3 4 4 4 0 Plasmid recombination enzyme SHNi-TPR PF10516.9 ETO07148.1 - 0.042 13.3 7.4 6.3 6.3 0.0 5.3 6 0 0 6 6 5 0 SHNi-TPR ChuX_HutX PF06228.13 ETO07148.1 - 0.066 13.0 0.1 25 4.7 0.0 4.1 2 2 3 5 5 5 0 Haem utilisation ChuX/HutX SPO22 PF08631.10 ETO07148.1 - 0.22 11.0 12.9 16 4.9 0.2 4.8 4 1 2 6 6 6 0 Meiosis protein SPO22/ZIP4 like DUF2745 PF10922.8 ETO07148.1 - 0.55 10.5 5.1 0.27 11.6 0.2 3.0 2 1 0 3 3 2 0 Protein of unknown function (DUF2745) Peripla_BP_7 PF18610.1 ETO07148.1 - 1.1 9.4 9.1 45 4.3 0.1 4.8 3 1 2 5 5 5 0 Periplasmic binding protein domain Fis1_TPR_C PF14853.6 ETO07148.1 - 4.5 7.4 23.9 3.8 7.7 0.1 6.4 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Phage_Treg PF04761.12 ETO07148.1 - 10 6.3 10.7 15 5.8 0.1 4.5 6 0 0 6 6 3 0 Lactococcus bacteriophage putative transcription regulator DUF2828 PF11443.8 ETO07150.1 - 0.00057 18.1 11.8 0.00066 17.9 11.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) Serinc PF03348.15 ETO07150.1 - 0.0014 17.6 1.8 0.002 17.1 1.8 1.3 1 0 0 1 1 1 1 Serine incorporator (Serinc) Vfa1 PF08432.10 ETO07150.1 - 0.008 16.5 19.1 0.012 16.0 19.1 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 NPR3 PF03666.13 ETO07150.1 - 0.01 14.7 13.7 0.014 14.2 13.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 ETO07150.1 - 0.015 15.2 13.8 0.021 14.7 13.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO07150.1 - 0.018 14.3 0.1 0.02 14.1 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO07150.1 - 0.032 12.5 12.4 0.04 12.2 12.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 ETO07150.1 - 0.047 13.8 1.7 0.057 13.6 1.7 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO07150.1 - 0.12 11.2 7.3 0.19 10.5 7.3 1.4 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO07150.1 - 0.24 10.3 3.6 0.32 9.9 3.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF262 PF03235.14 ETO07150.1 - 0.36 11.0 9.0 0.46 10.6 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF2207 PF09972.9 ETO07150.1 - 0.42 9.3 11.9 5.5 5.6 11.9 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Rtf2 PF04641.12 ETO07150.1 - 0.45 9.8 22.2 0.85 8.9 22.2 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger AAA_11 PF13086.6 ETO07150.1 - 1.5 8.6 14.2 1.9 8.2 14.2 1.1 1 0 0 1 1 1 0 AAA domain DUF4569 PF15133.6 ETO07150.1 - 2 8.1 10.1 2.6 7.7 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Afi1 PF07792.12 ETO07150.1 - 2.7 8.5 12.4 5.5 7.5 12.4 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking EMC3_TMCO1 PF01956.16 ETO07150.1 - 3 7.6 17.3 12 5.6 17.3 2.0 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ALMT PF11744.8 ETO07150.1 - 4.9 5.9 9.6 6.4 5.5 9.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MCM3AP_GANP PF16769.5 ETO07150.1 - 5 5.2 10.3 6.7 4.8 10.3 1.1 1 0 0 1 1 1 0 MCM3AP domain of GANP CLN3 PF02487.17 ETO07150.1 - 5.6 5.9 7.1 8 5.4 7.1 1.2 1 0 0 1 1 1 0 CLN3 protein MAP17 PF15807.5 ETO07150.1 - 6.9 6.9 17.3 12 6.1 17.3 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GNAT_acetyltr_2 PF13718.6 ETO07150.1 - 8.3 5.7 7.7 13 5.1 7.7 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 WD40 PF00400.32 ETO07151.1 - 5.1e-19 68.3 3.1 4.2e-06 27.4 0.1 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07151.1 - 0.00083 19.6 0.2 0.57 10.5 0.0 3.0 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07151.1 - 0.00092 18.0 0.5 0.46 9.1 0.0 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 STATa_Ig PF18214.1 ETO07151.1 - 0.067 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 STATa Immunoglobulin-like domain DUF4979 PF16351.5 ETO07151.1 - 0.29 11.4 5.7 0.92 9.7 0.9 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) NACHT PF05729.12 ETO07152.1 - 1.1e-10 41.6 0.0 2.5e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO07152.1 - 0.00016 22.2 0.0 0.00059 20.4 0.0 2.0 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO07152.1 - 0.00024 21.4 0.0 0.00081 19.7 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETO07152.1 - 0.01 15.4 0.0 0.02 14.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 ETO07152.1 - 0.014 14.6 0.1 0.026 13.8 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Glyco_hydro_38C PF07748.13 ETO07152.1 - 0.02 14.9 0.3 0.036 14.2 0.3 1.5 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal domain AAA_30 PF13604.6 ETO07152.1 - 0.021 14.5 0.0 0.037 13.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain ATP_bind_2 PF03668.15 ETO07152.1 - 0.052 12.8 0.0 0.093 12.0 0.0 1.4 1 0 0 1 1 1 0 P-loop ATPase protein family TniB PF05621.11 ETO07152.1 - 0.076 12.4 0.0 0.15 11.4 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_14 PF13173.6 ETO07152.1 - 0.085 12.9 0.2 0.3 11.1 0.2 2.0 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO07152.1 - 0.1 12.3 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Ferlin_C PF16165.5 ETO07152.1 - 0.26 11.2 2.7 1.3 8.9 0.1 2.7 3 0 0 3 3 3 0 Ferlin C-terminus ABC_tran PF00005.27 ETO07152.1 - 0.54 10.8 3.5 1.7 9.2 3.5 2.0 1 1 0 1 1 1 0 ABC transporter AAA_23 PF13476.6 ETO07152.1 - 6.6 7.2 13.6 0.23 11.9 5.3 2.5 2 2 0 2 2 2 0 AAA domain DUF1688 PF07958.11 ETO07153.1 - 0.0047 15.7 0.0 0.0061 15.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) CRS1_YhbY PF01985.21 ETO07155.1 - 0.41 10.8 3.2 0.15 12.3 0.8 1.6 2 0 0 2 2 2 0 CRS1 / YhbY (CRM) domain DSPc PF00782.20 ETO07157.1 - 2.5e-06 27.3 0.1 2.5e-06 27.3 0.1 5.8 6 1 1 7 7 7 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 ETO07157.1 - 0.038 13.7 0.3 0.22 11.2 0.0 2.4 2 0 0 2 2 2 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) PIN_9 PF18477.1 ETO07157.1 - 0.1 12.9 0.2 0.1 12.9 0.2 4.1 3 0 0 3 3 3 0 PIN like domain RVT_1 PF00078.27 ETO07158.1 - 1.1e-07 31.6 0.4 2.3e-07 30.6 0.4 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) KNTase_C PF07827.11 ETO07158.1 - 0.32 10.8 1.5 2.9 7.7 0.1 2.6 3 0 0 3 3 3 0 KNTase C-terminal domain Toprim_2 PF13155.6 ETO07159.1 - 9.9e-11 41.9 0.0 1.8e-10 41.1 0.0 1.5 1 0 0 1 1 1 1 Toprim-like Toprim_3 PF13362.6 ETO07159.1 - 8.6e-07 29.2 0.0 1.4e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Toprim domain Toprim_4 PF13662.6 ETO07159.1 - 2.6e-06 27.8 0.0 4.3e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Toprim domain Toprim PF01751.22 ETO07159.1 - 0.00021 21.5 0.0 0.00037 20.7 0.0 1.4 1 0 0 1 1 1 1 Toprim domain VPS13_mid_rpt PF16910.5 ETO07159.1 - 0.0019 17.7 0.3 0.0028 17.1 0.3 1.2 1 0 0 1 1 1 1 Repeating coiled region of VPS13 Rab3-GTPase_cat PF13890.6 ETO07159.1 - 0.076 12.6 0.0 0.11 12.1 0.0 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit ATP-synt_C PF00137.21 ETO07161.1 - 1.1e-25 89.8 27.7 2.6e-20 72.5 15.0 2.8 3 0 0 3 3 3 2 ATP synthase subunit C TCR_zetazeta PF11628.8 ETO07161.1 - 0.96 9.2 7.1 1.4 8.7 2.0 2.7 2 0 0 2 2 2 0 T-cell surface glycoprotein CD3 zeta chain DUF4577 PF15145.6 ETO07161.1 - 3.7 7.6 5.2 1.5 8.9 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) Membralin PF09746.9 ETO07162.1 - 2.2 7.2 5.4 2.7 7.0 5.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO07162.1 - 3.3 6.4 6.0 3.9 6.1 6.0 1.1 1 0 0 1 1 1 0 Presenilin CSRNP_N PF16019.5 ETO07162.1 - 4.1 7.3 12.1 2.1 8.2 10.2 1.5 1 1 1 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus Ureide_permease PF07168.11 ETO07162.1 - 6.4 5.4 5.4 7.2 5.3 5.0 1.3 1 1 0 1 1 1 0 Ureide permease WD40 PF00400.32 ETO07163.1 - 0.033 15.1 4.3 53 4.9 0.0 4.1 3 1 0 3 3 3 0 WD domain, G-beta repeat VTC PF09359.10 ETO07164.1 - 1.4e-14 54.1 0.3 2e-14 53.6 0.3 1.2 1 0 0 1 1 1 1 VTC domain Cwf_Cwc_15 PF04889.12 ETO07165.1 - 0.0044 16.8 9.9 0.0061 16.3 9.9 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF3245 PF11595.8 ETO07165.1 - 3.7 8.0 16.8 1.5 9.3 7.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3245) GIDA_assoc PF13932.6 ETO07166.1 - 6.3 6.9 7.8 8.3 6.5 3.2 2.7 3 0 0 3 3 3 0 GidA associated domain ECF_trnsprt PF12822.7 ETO07167.1 - 0.068 13.3 0.4 0.11 12.6 0.4 1.3 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Mito_carr PF00153.27 ETO07168.1 - 1.1e-09 38.1 0.2 0.00019 21.3 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein WD40 PF00400.32 ETO07169.1 - 1e-37 127.5 26.8 3.3e-07 30.9 1.0 7.7 7 3 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07169.1 - 4.2e-12 46.2 2.8 0.0088 16.3 0.0 6.0 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07169.1 - 1.2e-10 40.7 10.6 0.11 11.2 0.1 5.9 2 2 2 6 6 6 6 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO07169.1 - 0.12 11.1 7.8 0.25 10.0 3.6 3.2 2 2 0 3 3 3 0 Nup133 N terminal like DUF4979 PF16351.5 ETO07169.1 - 0.34 11.1 4.8 1.7 8.9 0.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4979) HSP70 PF00012.20 ETO07170.1 - 5.3e-93 312.2 0.9 7.4e-93 311.7 0.9 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO07170.1 - 4.7e-11 42.1 0.1 4.6e-10 38.8 0.0 2.0 2 0 0 2 2 2 1 MreB/Mbl protein Hydantoinase_A PF01968.18 ETO07170.1 - 0.018 14.3 1.3 0.07 12.4 0.2 2.2 2 1 0 2 2 2 0 Hydantoinase/oxoprolinase Maelstrom PF13017.6 ETO07170.1 - 0.04 13.6 0.2 0.062 12.9 0.2 1.4 1 0 0 1 1 1 0 piRNA pathway germ-plasm component Adeno_E3_CR2 PF02439.15 ETO07170.1 - 0.077 12.8 0.3 0.077 12.8 0.3 2.3 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 Orf78 PF06024.12 ETO07170.1 - 0.095 13.0 0.1 0.35 11.2 0.1 2.0 1 0 0 1 1 1 0 Orf78 (ac78) YajC PF02699.15 ETO07170.1 - 0.38 10.7 2.9 1.2 9.1 2.9 1.8 1 0 0 1 1 1 0 Preprotein translocase subunit HSP70 PF00012.20 ETO07171.1 - 1.2e-129 433.3 1.1 1.4e-129 433.1 1.1 1.0 1 0 0 1 1 1 1 Hsp70 protein FGGY_C PF02782.16 ETO07171.1 - 0.0083 15.9 0.0 0.034 13.9 0.0 2.0 2 0 0 2 2 2 1 FGGY family of carbohydrate kinases, C-terminal domain NPA PF16469.5 ETO07171.1 - 0.42 11.2 0.1 0.42 11.2 0.1 2.6 3 0 0 3 3 3 0 Nematode polyprotein allergen ABA-1 BRO1 PF03097.18 ETO07173.1 - 7.5e-20 71.1 0.0 8.8e-20 70.8 0.0 1.0 1 0 0 1 1 1 1 BRO1-like domain RVT_1 PF00078.27 ETO07174.1 - 3e-22 79.2 0.0 9.8e-22 77.6 0.0 1.9 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CENP-F_leu_zip PF10473.9 ETO07174.1 - 0.012 15.7 0.7 0.037 14.0 0.7 1.8 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.17 ETO07174.1 - 0.044 13.7 0.8 0.19 11.6 0.7 2.2 2 0 0 2 2 2 0 Prefoldin subunit DUF4200 PF13863.6 ETO07174.1 - 0.059 13.8 4.4 0.23 11.9 4.4 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF1664 PF07889.12 ETO07174.1 - 0.12 12.4 1.3 0.5 10.4 1.3 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ETO07174.1 - 0.24 11.8 1.6 0.96 9.9 1.6 2.1 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF3573 PF12097.8 ETO07174.1 - 1.4 7.7 8.0 3.6 6.3 8.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) BORCS7 PF16088.5 ETO07174.1 - 2.2 8.6 9.8 0.24 11.7 4.6 2.2 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 GIT_CC PF16559.5 ETO07174.1 - 3.3 7.6 8.6 13 5.8 8.6 2.0 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF641 PF04859.12 ETO07174.1 - 4.1 7.8 6.5 2.6 8.4 0.7 2.7 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) WD40 PF00400.32 ETO07176.1 - 2.6e-53 176.8 17.7 5.2e-11 42.9 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07176.1 - 2.4e-19 69.4 1.5 0.0002 21.6 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07176.1 - 1.6e-11 43.8 0.2 0.033 13.2 0.0 5.3 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein VID27 PF08553.10 ETO07176.1 - 1.5e-06 27.5 0.1 0.00029 20.0 0.0 2.9 1 1 2 3 3 3 1 VID27 C-terminal WD40-like domain Nup160 PF11715.8 ETO07176.1 - 3.4e-06 26.0 2.7 1.3 7.6 0.0 5.1 2 2 4 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07176.1 - 9.6e-06 25.1 4.3 0.072 12.4 0.1 3.3 1 1 0 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO07176.1 - 0.006 15.2 0.0 0.17 10.4 0.0 2.4 1 1 3 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO07176.1 - 0.02 14.8 13.1 18 5.4 0.4 5.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF727 PF05303.12 ETO07176.1 - 0.022 14.8 0.1 6.9 6.8 0.0 3.9 2 2 3 5 5 5 0 Protein of unknown function (DUF727) DUF5570 PF17731.1 ETO07176.1 - 0.036 14.1 0.5 7 6.8 0.0 3.4 2 2 1 3 3 3 0 Family of unknown function (DUF5570) DUF2527 PF10736.9 ETO07176.1 - 0.055 13.3 6.3 7.5 6.5 0.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF2627) Plk4_PB1 PF18190.1 ETO07176.1 - 0.85 9.8 3.0 20 5.4 0.1 4.0 4 2 1 5 5 5 0 Polo-like Kinase 4 Polo Box 1 DUF4999 PF16390.5 ETO07176.1 - 1.2 9.5 9.3 29 5.0 0.0 4.7 5 0 0 5 5 5 0 Domain of unknown function Plant_tran PF04827.14 ETO07177.1 - 0.062 12.9 0.0 0.072 12.7 0.0 1.2 1 0 0 1 1 1 0 Plant transposon protein CAP18_C PF12153.8 ETO07178.1 - 0.02 14.7 2.5 0.055 13.3 2.5 1.9 1 0 0 1 1 1 0 LPS binding domain of CAP18 (C terminal) Myb_DNA-binding PF00249.31 ETO07178.1 - 0.062 13.5 0.8 0.53 10.5 0.8 2.1 1 1 0 1 1 1 0 Myb-like DNA-binding domain DUF1600 PF07667.11 ETO07179.1 - 0.018 15.2 6.2 0.027 14.7 5.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1600) Ribosomal_L2 PF00181.23 ETO07179.1 - 0.03 14.3 0.0 0.057 13.4 0.0 1.4 1 0 0 1 1 1 0 Ribosomal Proteins L2, RNA binding domain DUF4834 PF16118.5 ETO07179.1 - 0.71 10.9 6.2 1.7 9.6 6.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO07182.1 - 2.1e-17 63.2 4.2 1.2e-05 25.9 0.2 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07182.1 - 9.9e-05 22.6 0.2 4.2 7.8 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07182.1 - 0.00026 19.8 0.4 0.8 8.3 0.0 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO07182.1 - 1.5 9.0 7.2 3.1 8.0 2.1 2.4 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO07183.1 - 5.9e-09 36.4 1.0 0.14 13.1 0.1 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07183.1 - 0.024 14.9 0.0 0.032 14.5 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DAP PF15228.6 ETO07184.1 - 5.8 8.2 19.2 0.14 13.4 2.9 2.2 2 0 0 2 2 2 0 Death-associated protein MipZ PF09140.11 ETO07184.1 - 7.5 5.7 10.0 0.57 9.4 4.7 1.7 1 1 1 2 2 2 0 ATPase MipZ Nucleolin_bd PF16725.5 ETO07185.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 Nucleolin binding domain ThrE PF06738.12 ETO07185.1 - 0.12 11.7 0.0 0.14 11.5 0.0 1.1 1 0 0 1 1 1 0 Putative threonine/serine exporter ABC_tran PF00005.27 ETO07186.1 - 4.3e-16 59.7 4.8 1.1e-14 55.1 4.8 2.6 1 1 0 1 1 1 1 ABC transporter AAA_15 PF13175.6 ETO07186.1 - 1.5e-06 28.2 6.8 2.8e-06 27.3 6.8 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO07186.1 - 0.00091 18.9 0.0 0.0027 17.4 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain RMI1_N PF08585.12 ETO07186.1 - 0.0025 17.6 3.1 0.0048 16.7 3.1 1.4 1 0 0 1 1 1 1 RecQ mediated genome instability protein AAA_23 PF13476.6 ETO07186.1 - 0.005 17.4 7.5 0.016 15.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 ETO07186.1 - 0.0053 16.7 1.9 0.97 9.3 0.2 2.8 2 1 0 2 2 2 2 ATPase domain predominantly from Archaea ABC_membrane PF00664.23 ETO07186.1 - 0.0098 15.6 0.3 0.02 14.6 0.3 1.4 1 0 0 1 1 1 1 ABC transporter transmembrane region MMR_HSR1 PF01926.23 ETO07186.1 - 0.014 15.5 0.1 1.6 8.8 0.0 3.1 3 0 0 3 3 3 0 50S ribosome-binding GTPase DUF4048 PF13257.6 ETO07186.1 - 0.11 12.3 7.8 0.2 11.5 7.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) TFIIA PF03153.13 ETO07186.1 - 0.14 12.1 13.5 0.23 11.4 13.5 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pox_Ag35 PF03286.14 ETO07186.1 - 0.26 11.1 11.0 0.51 10.1 11.0 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Tim54 PF11711.8 ETO07186.1 - 0.42 9.4 4.7 0.71 8.6 4.7 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5523 PF17661.1 ETO07186.1 - 0.62 9.7 9.5 1.1 8.9 9.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Zip PF02535.22 ETO07186.1 - 0.79 8.9 2.1 1.4 8.1 2.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ETO07186.1 - 1 9.3 9.6 1.9 8.4 9.6 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ETO07186.1 - 9.5 4.9 9.8 15 4.2 9.8 1.2 1 0 0 1 1 1 0 Presenilin Rop-like PF05082.13 ETO07187.1 - 0.0028 17.4 1.4 0.006 16.4 1.4 1.5 1 0 0 1 1 1 1 Rop-like AAA_13 PF13166.6 ETO07187.1 - 0.0029 16.3 6.3 0.0033 16.1 6.3 1.0 1 0 0 1 1 1 1 AAA domain DUF1043 PF06295.12 ETO07187.1 - 0.0041 17.1 3.1 0.0041 17.1 3.1 1.8 2 1 0 2 2 2 1 Protein of unknown function (DUF1043) SlyX PF04102.12 ETO07187.1 - 0.01 16.4 3.2 0.013 16.1 1.5 2.0 2 0 0 2 2 2 0 SlyX CSN5_C PF18323.1 ETO07187.1 - 0.011 16.7 4.8 0.043 14.7 4.3 2.2 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain SKA1 PF07160.12 ETO07187.1 - 0.016 15.1 7.8 0.024 14.5 7.8 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 YscO PF07321.12 ETO07187.1 - 0.034 14.1 2.4 2.6 8.0 2.0 2.2 2 0 0 2 2 2 0 Type III secretion protein YscO LMBR1 PF04791.16 ETO07187.1 - 0.037 12.9 5.9 0.04 12.8 5.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 ETO07187.1 - 0.069 11.1 3.9 0.075 10.9 3.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TCP PF03634.13 ETO07187.1 - 0.11 13.0 8.7 0.2 12.2 8.7 1.4 1 0 0 1 1 1 0 TCP family transcription factor Tropomyosin_1 PF12718.7 ETO07187.1 - 0.32 11.1 9.4 0.2 11.8 7.3 1.7 2 1 0 2 2 2 0 Tropomyosin like Striatin PF08232.12 ETO07187.1 - 0.75 10.4 10.1 0.97 10.0 10.1 1.3 1 1 0 1 1 1 0 Striatin family FAM60A PF15396.6 ETO07187.1 - 1.9 8.4 6.0 2.8 7.9 6.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Fib_alpha PF08702.10 ETO07187.1 - 6.8 6.9 15.3 17 5.6 12.8 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 ETO07187.1 - 9.8 5.4 12.2 0.38 10.0 3.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) RasGEF PF00617.19 ETO07188.1 - 0.0013 18.9 0.0 0.0023 18.2 0.0 1.4 1 1 0 1 1 1 1 RasGEF domain DUF5436 PF17504.2 ETO07189.1 - 0.046 14.0 5.3 0.23 11.8 5.3 2.2 1 1 0 1 1 1 0 Family of unknown function (DUF5436) Hydin_ADK PF17213.3 ETO07190.1 - 0.75 10.0 13.6 0.45 10.8 1.2 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain RPN2_C PF18004.1 ETO07190.1 - 3.8 7.4 17.8 1.7 8.6 6.9 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain TMEM119 PF15724.5 ETO07190.1 - 7 6.6 10.2 0.26 11.3 2.9 2.0 2 0 0 2 2 2 0 TMEM119 family Apis_Csd PF11671.8 ETO07190.1 - 7.7 6.5 10.3 12 5.9 3.0 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein TFIIF_alpha PF05793.12 ETO07191.1 - 0.0001 21.1 17.6 0.00011 21.0 17.6 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 ETO07191.1 - 0.0018 17.8 17.5 0.0018 17.8 17.5 1.0 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO07191.1 - 0.0036 15.6 20.5 0.0035 15.6 20.5 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2052 PF09747.9 ETO07191.1 - 0.025 14.7 17.8 0.028 14.6 17.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) SpoIIIAH PF12685.7 ETO07191.1 - 0.086 12.7 6.7 0.078 12.8 6.7 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Mpp10 PF04006.12 ETO07191.1 - 0.1 11.0 21.8 0.1 11.0 21.8 1.0 1 0 0 1 1 1 0 Mpp10 protein BUD22 PF09073.10 ETO07191.1 - 0.11 11.8 18.9 0.11 11.8 18.9 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETO07191.1 - 0.23 9.7 17.4 0.21 9.8 17.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 ETO07191.1 - 0.29 9.9 12.9 0.33 9.7 12.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4770 PF15994.5 ETO07191.1 - 0.57 10.4 3.5 0.7 10.1 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) CNDH2_C PF16858.5 ETO07191.1 - 0.83 9.5 10.3 0.84 9.5 10.3 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term NPR3 PF03666.13 ETO07191.1 - 1.1 8.0 8.5 1.1 8.0 8.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 ETO07191.1 - 1.2 8.6 9.2 1.2 8.6 9.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Vfa1 PF08432.10 ETO07191.1 - 1.3 9.3 11.4 1.5 9.1 11.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 XAP5 PF04921.14 ETO07191.1 - 1.9 8.3 10.7 2.2 8.1 10.7 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator MRNIP PF15749.5 ETO07191.1 - 2 9.2 7.6 2.4 8.9 7.6 1.3 1 0 0 1 1 1 0 MRN-interacting protein Presenilin PF01080.17 ETO07191.1 - 2.3 6.9 7.4 2.1 7.0 7.4 1.1 1 0 0 1 1 1 0 Presenilin YL1 PF05764.13 ETO07191.1 - 2.7 8.1 21.5 2.7 8.0 21.5 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Afi1 PF07792.12 ETO07191.1 - 3.7 8.1 14.3 4.8 7.7 14.3 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Med17 PF10156.9 ETO07191.1 - 4.7 5.8 8.7 4.3 5.9 8.7 1.1 1 0 0 1 1 1 0 Subunit 17 of Mediator complex CobT PF06213.12 ETO07191.1 - 4.7 6.5 26.9 5.4 6.3 26.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4637 PF15470.6 ETO07191.1 - 5.6 6.7 25.1 8.1 6.1 25.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Menin PF05053.13 ETO07191.1 - 6.7 4.9 7.7 6.3 5.0 7.7 1.0 1 0 0 1 1 1 0 Menin SMN PF06003.12 ETO07191.1 - 6.8 5.9 11.2 8 5.6 11.2 1.0 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Lin-8 PF03353.15 ETO07191.1 - 8.2 5.9 13.9 8.8 5.8 13.9 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF2722 PF10846.8 ETO07191.1 - 8.8 5.2 14.8 11 4.9 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DNA_pol_phi PF04931.13 ETO07191.1 - 9 4.3 37.3 10 4.1 37.3 1.0 1 0 0 1 1 1 0 DNA polymerase phi Casc1 PF12366.8 ETO07193.1 - 0.00078 19.0 1.8 0.00092 18.8 1.8 1.0 1 0 0 1 1 1 1 Cancer susceptibility candidate 1 MMR_HSR1 PF01926.23 ETO07194.1 - 3.9e-15 55.9 0.1 4.2e-13 49.4 0.0 2.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase DUF2207 PF09972.9 ETO07194.1 - 3.2e-06 26.2 1.7 3.2e-06 26.2 1.7 2.9 3 0 0 3 3 3 2 Predicted membrane protein (DUF2207) FeoB_N PF02421.18 ETO07194.1 - 1.2e-05 24.9 0.1 3.4e-05 23.4 0.1 1.8 1 0 0 1 1 1 1 Ferrous iron transport protein B RsgA_GTPase PF03193.16 ETO07194.1 - 0.00038 20.4 0.4 0.016 15.1 0.1 2.7 2 0 0 2 2 2 1 RsgA GTPase LRRC37AB_C PF14914.6 ETO07194.1 - 0.0009 19.2 3.0 0.0009 19.2 3.0 5.3 3 1 3 6 6 3 1 LRRC37A/B like protein 1 C-terminal domain AmpE PF17113.5 ETO07194.1 - 0.0024 17.2 0.6 0.0046 16.3 0.6 1.4 1 0 0 1 1 1 1 Regulatory signalling modulator protein AmpE Wzy_C PF04932.15 ETO07194.1 - 0.0059 16.2 0.0 0.015 14.9 0.0 1.7 1 0 0 1 1 1 1 O-Antigen ligase DUF2244 PF10003.9 ETO07194.1 - 0.057 13.1 0.3 0.11 12.1 0.3 1.4 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) Sporozoite_P67 PF05642.11 ETO07194.1 - 0.15 10.1 19.0 0.043 11.9 15.1 1.9 1 1 1 2 2 2 0 Sporozoite P67 surface antigen MMPL PF03176.15 ETO07194.1 - 0.17 10.8 2.8 0.33 9.9 2.8 1.4 1 0 0 1 1 1 0 MMPL family DUF4366 PF14283.6 ETO07194.1 - 0.34 11.0 0.0 0.34 11.0 0.0 4.5 3 1 1 4 4 2 0 Domain of unknown function (DUF4366) Shisa PF13908.6 ETO07194.1 - 0.61 10.3 13.0 0.25 11.6 5.4 3.6 3 1 0 3 3 3 0 Wnt and FGF inhibitory regulator CDC45 PF02724.14 ETO07194.1 - 1.6 6.9 45.4 0.061 11.6 28.1 2.5 2 0 0 2 2 2 0 CDC45-like protein DUF4191 PF13829.6 ETO07194.1 - 2.5 7.4 10.4 1.1 8.5 6.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) AA_permease_2 PF13520.6 ETO07194.1 - 3.5 6.3 18.1 0.82 8.4 10.6 2.1 2 0 0 2 2 2 0 Amino acid permease WD40 PF00400.32 ETO07195.1 - 4.1e-14 52.8 12.7 2.1e-07 31.5 0.3 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07195.1 - 1.5e-05 25.2 0.1 0.66 10.3 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07195.1 - 0.001 18.5 0.6 0.0033 16.8 0.6 1.8 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO07195.1 - 0.044 12.4 0.0 2 6.9 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 BLF1 PF17752.1 ETO07195.1 - 0.066 12.5 0.1 0.11 11.9 0.0 1.3 1 1 0 1 1 1 0 Burkholderia lethal factor 1 WD40 PF00400.32 ETO07197.1 - 1.4e-30 104.9 20.8 2.6e-08 34.4 0.0 9.1 9 1 0 9 9 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07197.1 - 4.7e-20 71.7 2.6 0.0005 20.3 0.0 7.8 4 1 5 9 9 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07197.1 - 6e-08 32.0 1.6 0.026 13.5 0.0 5.8 2 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO07197.1 - 5e-05 23.1 0.9 3.7 7.6 0.0 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Kelch_6 PF13964.6 ETO07197.1 - 0.00025 21.2 2.7 3.5 8.1 0.1 4.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO07197.1 - 0.00069 19.6 0.7 0.17 11.9 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO07197.1 - 0.00095 18.7 1.5 0.45 10.2 0.0 3.5 3 0 0 3 3 3 1 Kelch motif PUB PF09409.10 ETO07197.1 - 0.0018 18.2 1.1 0.008 16.1 0.2 2.5 2 0 0 2 2 2 1 PUB domain PQQ_2 PF13360.6 ETO07197.1 - 0.019 14.6 0.0 0.2 11.2 0.0 2.4 2 1 0 2 2 2 0 PQQ-like domain N_Asn_amidohyd PF14736.6 ETO07197.1 - 0.022 13.9 0.1 5.6 6.0 0.0 2.3 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Cytochrom_D1 PF02239.16 ETO07197.1 - 0.028 12.9 0.0 0.47 8.9 0.0 2.8 2 1 1 3 3 3 0 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO07197.1 - 3.4 7.8 10.2 1.8 8.6 0.1 4.4 5 0 0 5 5 5 0 Kelch motif Kelch_6 PF13964.6 ETO07198.1 - 1.5e-05 25.1 3.8 0.94 9.9 0.1 3.6 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ETO07198.1 - 0.0014 18.6 0.7 1.6 8.8 0.1 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO07198.1 - 0.0042 16.6 6.1 0.22 11.1 0.3 3.2 3 0 0 3 3 3 2 Kelch motif DUF1391 PF07151.12 ETO07198.1 - 0.0052 16.6 0.8 0.47 10.3 0.3 2.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1391) Kelch_5 PF13854.6 ETO07198.1 - 0.48 10.5 10.4 7.9 6.6 0.1 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO07198.1 - 1.2 9.3 6.0 2.6 8.2 0.2 3.6 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO07199.1 - 1.8e-47 158.3 12.6 1.3e-09 38.5 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07199.1 - 2.5e-23 82.2 0.3 0.0013 19.0 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07199.1 - 4.8e-15 55.4 0.2 1.6e-05 24.0 0.0 5.6 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO07199.1 - 4.9e-09 35.9 9.6 0.47 10.5 0.0 7.1 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO07199.1 - 2.7e-07 30.2 1.2 0.0009 18.7 0.2 2.3 1 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO07199.1 - 4.8e-05 22.2 0.9 0.3 9.7 0.1 4.2 1 1 2 3 3 3 1 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO07199.1 - 0.019 14.0 0.9 1.6 7.7 0.1 2.5 2 1 1 3 3 3 0 Coatomer WD associated region VID27 PF08553.10 ETO07199.1 - 0.021 13.9 1.1 0.85 8.6 0.4 3.3 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain Frtz PF11768.8 ETO07199.1 - 0.039 12.3 0.0 0.36 9.1 0.0 2.3 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF1854 PF08909.11 ETO07199.1 - 0.11 12.3 0.6 45 3.9 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF1854) HMG_box PF00505.19 ETO07200.1 - 4.3e-21 75.1 6.9 4.3e-21 75.1 6.9 4.1 4 1 1 5 5 5 2 HMG (high mobility group) box HMG_box_2 PF09011.10 ETO07200.1 - 1.3e-11 44.9 5.3 1.3e-11 44.9 5.3 4.1 4 0 0 4 4 4 1 HMG-box domain FAM70 PF14967.6 ETO07200.1 - 0.086 12.3 1.0 0.15 11.5 1.0 1.3 1 0 0 1 1 1 0 FAM70 protein DUF4303 PF14136.6 ETO07201.1 - 0.0087 15.8 0.1 0.02 14.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4303) ZZ PF00569.17 ETO07201.1 - 0.089 12.6 1.6 0.28 11.0 1.6 1.8 1 0 0 1 1 1 0 Zinc finger, ZZ type Afi1 PF07792.12 ETO07202.1 - 0.025 15.0 17.4 0.57 10.7 8.5 2.5 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Inhibitor_I71 PF12628.7 ETO07202.1 - 0.57 10.0 8.0 0.093 12.6 3.1 2.1 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor DUF755 PF05501.11 ETO07202.1 - 0.71 10.2 18.0 0.11 12.7 1.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF755) TLP-20 PF06088.11 ETO07202.1 - 0.81 9.6 12.5 0.071 13.0 3.7 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Presenilin PF01080.17 ETO07202.1 - 1.1 7.9 4.1 2.4 6.8 0.8 2.1 2 0 0 2 2 2 0 Presenilin Pox_Ag35 PF03286.14 ETO07202.1 - 6.8 6.4 15.8 4.6 7.0 11.2 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Peptidase_M1 PF01433.20 ETO07203.1 - 2.1e-21 76.5 0.0 2.4e-21 76.3 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M1 domain ERAP1_C PF11838.8 ETO07204.1 - 2.1e-10 40.7 0.1 2.7e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain FMO-like PF00743.19 ETO07205.1 - 2e-10 39.7 0.3 2.2e-10 39.6 0.3 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like His_Phos_1 PF00300.22 ETO07206.1 - 1.6e-05 24.7 0.0 7.9 6.1 0.0 4.4 3 1 1 4 4 4 3 Histidine phosphatase superfamily (branch 1) Pox_Ag35 PF03286.14 ETO07206.1 - 0.002 17.9 1.2 0.002 17.9 1.2 2.7 2 1 0 2 2 2 1 Pox virus Ag35 surface protein PROCN PF08083.11 ETO07206.1 - 0.086 11.5 0.0 0.16 10.7 0.0 1.3 1 0 0 1 1 1 0 PROCN (NUC071) domain PPL5 PF18168.1 ETO07206.1 - 1 8.6 11.3 0.97 8.7 1.5 2.4 2 0 0 2 2 2 0 Prim-pol family 5 PDDEXK_6 PF04720.12 ETO07206.1 - 6.9 6.5 13.8 2.4 8.0 1.8 2.8 3 0 0 3 3 3 0 PDDEXK-like family of unknown function Pkinase_Tyr PF07714.17 ETO07207.1 - 7.5e-44 149.9 0.0 2.3e-43 148.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ETO07207.1 - 3.8e-27 95.3 0.0 7e-27 94.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO07207.1 - 3.2e-05 22.9 0.8 5.3e-05 22.2 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO07207.1 - 0.034 13.5 0.1 0.057 12.8 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APC_N_CC PF16689.5 ETO07207.1 - 0.069 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 Coiled-coil N-terminus of APC, dimerisation domain LRR_8 PF13855.6 ETO07208.1 - 4.9e-12 45.4 49.3 3.7e-05 23.4 6.7 4.5 1 1 6 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 ETO07208.1 - 9.2e-08 32.3 27.9 0.0042 17.4 0.6 5.3 3 2 1 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO07208.1 - 0.0028 18.0 16.3 1.5 9.7 0.3 6.9 7 2 0 7 7 7 1 Leucine Rich Repeat TRCF PF03461.15 ETO07208.1 - 0.13 12.7 0.6 52 4.3 0.0 3.6 1 1 3 4 4 4 0 TRCF domain NPR3 PF03666.13 ETO07209.1 - 0.033 13.0 9.5 0.047 12.5 9.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CSRNP_N PF16019.5 ETO07209.1 - 1.3 8.9 6.2 2 8.3 6.2 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus SMYLE_N PF18615.1 ETO07209.1 - 1.5 8.3 7.7 2.1 7.8 7.7 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Presenilin PF01080.17 ETO07209.1 - 2.2 6.9 13.8 3.5 6.3 13.8 1.3 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO07209.1 - 6.9 5.6 14.7 10 5.0 14.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PAZ_siRNAbind PF12212.8 ETO07210.1 - 0.033 14.0 2.3 0.031 14.1 1.4 1.6 1 1 0 1 1 1 0 PAZ domain Kelch_6 PF13964.6 ETO07211.1 - 2.2e-06 27.8 2.5 0.00044 20.4 0.2 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO07211.1 - 1.2e-05 24.7 0.4 0.0082 15.7 0.1 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO07211.1 - 0.00028 20.8 1.0 0.0019 18.1 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO07211.1 - 0.0004 20.3 5.2 0.62 10.1 0.3 5.1 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.15 ETO07211.1 - 0.001 18.9 1.7 0.069 13.2 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO07211.1 - 0.0018 18.5 0.2 0.019 15.3 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain RdRP_5 PF07925.11 ETO07212.1 - 0.1 10.0 0.0 0.1 10.0 0.0 1.5 2 0 0 2 2 2 0 Reovirus RNA-dependent RNA polymerase lambda 3 SSP160 PF06933.11 ETO07212.1 - 0.1 10.8 4.5 0.14 10.4 4.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AIM3 PF17096.5 ETO07212.1 - 7.1 7.6 8.1 3.3 8.7 5.2 1.8 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 LMBR1 PF04791.16 ETO07213.1 - 0.00054 19.0 2.1 0.00057 18.9 2.1 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF4407 PF14362.6 ETO07213.1 - 0.0089 15.4 0.8 0.011 15.1 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) DUF2207 PF09972.9 ETO07213.1 - 0.0099 14.7 3.1 0.011 14.6 3.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) ABC2_membrane_3 PF12698.7 ETO07213.1 - 0.011 14.9 0.2 0.012 14.7 0.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein NPIP PF06409.11 ETO07213.1 - 0.02 14.0 3.7 0.027 13.5 3.7 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Orf78 PF06024.12 ETO07213.1 - 0.021 15.1 5.0 0.035 14.4 4.9 1.4 1 1 0 1 1 1 0 Orf78 (ac78) Csd3_N PF18059.1 ETO07213.1 - 0.028 14.9 3.1 0.056 14.0 2.7 1.7 1 1 1 2 2 2 0 Csd3 N-terminal EMC3_TMCO1 PF01956.16 ETO07213.1 - 0.2 11.4 4.6 0.3 10.8 4.6 1.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF3450 PF11932.8 ETO07213.1 - 0.26 10.6 8.7 0.34 10.2 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Exonuc_VII_L PF02601.15 ETO07213.1 - 0.58 9.7 5.5 0.7 9.4 5.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit YlqD PF11068.8 ETO07213.1 - 1.1 9.6 12.1 1.5 9.2 12.1 1.1 1 0 0 1 1 1 0 YlqD protein AAA_11 PF13086.6 ETO07213.1 - 1.2 8.9 6.8 1.5 8.6 6.8 1.0 1 0 0 1 1 1 0 AAA domain Fzo_mitofusin PF04799.13 ETO07213.1 - 1.9 8.0 9.4 0.64 9.5 6.5 1.7 1 1 0 1 1 1 0 fzo-like conserved region WD40 PF00400.32 ETO07215.1 - 2.6e-113 366.7 41.9 6e-09 36.4 0.3 14.2 14 0 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07215.1 - 1.7e-23 82.7 13.8 0.33 11.3 0.5 11.4 1 1 8 10 10 10 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07215.1 - 2.3e-22 79.4 14.6 0.047 12.6 1.1 12.0 1 1 10 11 11 11 9 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO07215.1 - 2.7e-12 46.2 27.0 0.39 9.3 0.1 10.7 2 2 6 10 10 10 7 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07215.1 - 1.7e-07 30.9 16.2 0.067 12.5 0.2 6.2 4 1 2 7 7 7 5 WD40-like domain PD40 PF07676.12 ETO07215.1 - 3e-05 23.8 8.6 40 4.3 0.4 7.4 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO07215.1 - 4.5e-05 23.0 4.7 0.0014 18.2 1.7 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO07215.1 - 0.00012 22.2 0.1 0.00041 20.4 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Peptidase_C9 PF01707.16 ETO07215.1 - 0.0067 16.0 0.5 0.023 14.3 0.5 1.9 1 0 0 1 1 1 1 Peptidase family C9 Pentapeptide_3 PF13576.6 ETO07215.1 - 0.026 14.7 0.2 0.13 12.5 0.2 2.2 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) NACHT PF05729.12 ETO07216.1 - 1.4e-08 34.9 0.0 5.6e-08 32.9 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ETO07216.1 - 7.6e-05 23.0 0.1 0.00057 20.2 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETO07216.1 - 0.0097 16.3 0.0 0.036 14.5 0.0 2.0 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO07216.1 - 0.014 15.9 0.3 0.19 12.3 0.2 3.1 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO07216.1 - 0.018 15.5 0.1 0.21 11.9 0.1 2.7 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 ETO07216.1 - 0.045 14.3 0.6 0.49 10.9 0.0 2.8 2 0 0 2 2 2 0 ABC transporter PduV-EutP PF10662.9 ETO07216.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 ETO07216.1 - 0.16 12.4 1.2 0.75 10.2 0.2 2.9 2 1 0 2 2 2 0 RNA helicase RGS PF00615.19 ETO07218.1 - 1.2e-07 32.0 1.1 2e-07 31.3 1.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Y1_Tnp PF01797.16 ETO07218.1 - 0.047 13.8 0.3 0.21 11.7 0.0 2.2 3 0 0 3 3 3 0 Transposase IS200 like Adap_comp_sub PF00928.21 ETO07219.1 - 6.5e-31 107.7 0.1 8e-31 107.4 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family muHD PF10291.9 ETO07219.1 - 0.0028 17.2 0.0 0.0035 16.8 0.0 1.1 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain TPR_12 PF13424.6 ETO07220.1 - 2.6e-72 239.1 5.1 3.5e-21 75.3 0.1 5.4 2 2 3 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07220.1 - 1.5e-60 199.5 0.0 4.1e-10 39.2 0.0 7.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07220.1 - 6.9e-45 149.1 34.2 1.5e-10 40.5 1.2 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07220.1 - 9.2e-44 144.3 2.7 1.2e-08 34.4 0.1 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07220.1 - 1.8e-32 108.8 33.6 1.1e-07 31.5 1.1 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07220.1 - 1.9e-30 102.5 21.3 3.2e-06 26.8 0.5 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO07220.1 - 3.3e-19 67.8 8.6 0.0047 17.2 0.0 7.7 8 1 0 8 8 7 4 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO07220.1 - 1.8e-13 50.6 0.0 8e-06 25.4 0.0 2.6 1 1 2 3 3 3 3 MalT-like TPR region DUF5113 PF17140.4 ETO07220.1 - 2.4e-12 46.9 16.8 0.0074 16.1 0.2 6.5 5 2 2 7 7 7 4 Domain of unknown function (DUF5113) PPR PF01535.20 ETO07220.1 - 6.4e-12 44.9 10.8 0.037 14.3 0.1 6.2 6 0 0 6 6 6 4 PPR repeat TPR_14 PF13428.6 ETO07220.1 - 3.8e-10 39.7 0.0 0.59 11.1 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO07220.1 - 4.2e-09 36.9 0.0 0.24 12.1 0.0 5.5 5 1 0 5 5 5 1 Tetratricopeptide repeat SNAP PF14938.6 ETO07220.1 - 8.7e-09 35.2 7.6 5.8e-05 22.7 1.0 3.6 1 1 3 4 4 4 4 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO07220.1 - 1.5e-07 31.0 38.2 0.022 14.4 0.8 10.3 8 4 4 12 12 11 6 TPR repeat MIT PF04212.18 ETO07220.1 - 3.3e-07 30.3 17.1 0.56 10.3 0.2 6.0 7 0 0 7 7 6 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO07220.1 - 1.6e-06 28.4 0.7 8.2 7.3 0.0 6.9 7 1 0 7 7 7 0 Tetratricopeptide repeat RPN7 PF10602.9 ETO07220.1 - 4.3e-06 26.5 13.8 0.016 14.9 0.8 5.6 1 1 5 6 6 6 2 26S proteasome subunit RPN7 OrfA PF17495.2 ETO07220.1 - 5.2e-06 26.6 0.0 1.2 9.4 0.0 4.6 1 1 3 5 5 5 1 Vpr-like OrfA DUF357 PF04010.13 ETO07220.1 - 6.8e-05 22.9 9.9 5.8 7.1 0.1 5.2 2 1 3 5 5 5 0 Protein of unknown function (DUF357) KH_4 PF13083.6 ETO07220.1 - 9.9e-05 22.1 0.0 2.9 7.8 0.0 4.3 1 1 3 4 4 4 1 KH domain TPR_3 PF07720.12 ETO07220.1 - 0.0013 18.6 15.2 1.5 8.9 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETO07220.1 - 0.0028 17.4 3.1 0.042 13.5 0.0 3.5 2 2 0 2 2 2 1 Tetratricopeptide repeat-like domain DUF4810 PF16068.5 ETO07220.1 - 0.0039 17.7 6.9 2.4 8.8 0.1 4.7 2 1 3 5 5 5 1 Domain of unknown function (DUF4810) TPR_19 PF14559.6 ETO07220.1 - 0.0042 17.6 0.8 3.2 8.3 0.1 4.3 3 2 2 5 5 4 1 Tetratricopeptide repeat ILEI PF15711.5 ETO07220.1 - 0.005 17.3 0.3 28 5.3 0.0 4.0 2 1 2 4 4 4 0 Interleukin-like EMT inducer SHNi-TPR PF10516.9 ETO07220.1 - 0.011 15.2 3.5 18 4.9 0.0 5.4 7 0 0 7 7 7 0 SHNi-TPR YecM PF06185.12 ETO07220.1 - 0.013 15.2 3.3 17 5.0 0.1 4.2 3 1 1 4 4 4 0 YecM protein bPH_3 PF14470.6 ETO07220.1 - 0.045 14.1 5.4 5.2 7.5 0.0 4.2 2 2 2 4 4 4 0 Bacterial PH domain Mob_Pre PF01076.19 ETO07220.1 - 0.082 12.7 0.3 0.082 12.7 0.3 3.1 3 1 1 4 4 4 0 Plasmid recombination enzyme FATC PF02260.20 ETO07220.1 - 0.16 11.8 0.0 1.3e+02 2.5 0.0 3.7 4 0 0 4 4 4 0 FATC domain CLTH PF10607.9 ETO07220.1 - 0.21 11.5 2.1 0.46 10.4 0.1 2.5 2 2 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain NRBF2_MIT PF17169.4 ETO07220.1 - 0.25 11.6 7.5 21 5.4 0.1 4.9 4 1 1 5 5 5 0 MIT domain of nuclear receptor-binding factor 2 HTH_Bact PF18768.1 ETO07220.1 - 0.75 9.4 13.7 7.3 6.3 0.1 6.5 6 1 1 8 8 8 0 Helix-turn-helix bacterial domain HDV_ag PF01517.18 ETO07220.1 - 1 9.1 3.0 8.7 6.1 0.1 2.8 2 1 0 3 3 3 0 Hepatitis delta virus delta antigen SLT PF01464.20 ETO07220.1 - 1.2 8.8 6.4 15 5.3 0.1 4.4 2 2 5 7 7 7 0 Transglycosylase SLT domain E7 PF00527.18 ETO07222.1 - 0.009 16.2 0.3 0.016 15.4 0.3 1.4 1 0 0 1 1 1 1 E7 protein, Early protein MLD PF11647.8 ETO07224.1 - 0.017 15.3 0.0 1.1 9.6 0.1 2.5 2 0 0 2 2 2 0 Membrane Localization Domain WD40 PF00400.32 ETO07225.1 - 3.2e-40 135.4 25.3 5.5e-07 30.2 1.2 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07225.1 - 3.8e-13 49.5 4.2 0.0024 18.1 0.0 5.2 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07225.1 - 2.5e-06 26.5 8.2 0.35 9.5 0.2 5.1 1 1 4 5 5 5 5 Nucleoporin Nup120/160 EF-hand_1 PF00036.32 ETO07226.1 - 1.5e-09 36.7 4.0 1.9e-05 23.9 0.4 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO07226.1 - 1.1e-08 34.3 2.9 0.00035 20.3 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO07226.1 - 7.4e-07 28.4 3.8 0.012 15.1 0.5 2.3 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO07226.1 - 1e-05 25.9 9.3 0.0005 20.5 3.4 2.1 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO07226.1 - 0.0015 18.8 1.6 0.0018 18.6 0.8 1.5 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region Muted PF14942.6 ETO07226.1 - 0.0053 17.1 0.5 0.0064 16.9 0.5 1.1 1 0 0 1 1 1 1 Organelle biogenesis, Muted-like protein EF-hand_8 PF13833.6 ETO07226.1 - 0.044 13.6 4.5 0.26 11.2 0.3 2.2 1 1 1 2 2 2 0 EF-hand domain pair DUF1007 PF06226.13 ETO07226.1 - 0.099 12.6 3.8 1.7 8.6 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1007) PABP PF00658.18 ETO07227.1 - 2.4e-24 85.3 0.9 4.8e-24 84.3 0.9 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-TRAF PF02176.18 ETO07227.1 - 0.00023 21.8 0.9 0.00043 20.9 0.9 1.4 1 0 0 1 1 1 1 TRAF-type zinc finger YabA PF06156.13 ETO07227.1 - 0.093 13.4 9.8 0.041 14.5 4.3 2.8 2 1 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 ETO07227.1 - 0.17 11.6 3.3 0.39 10.5 2.6 2.0 1 1 0 1 1 1 0 Septum formation initiator ZapB PF06005.12 ETO07227.1 - 0.99 9.9 10.9 0.42 11.1 2.1 2.7 2 0 0 2 2 2 0 Cell division protein ZapB PT PF04886.12 ETO07228.1 - 0.0058 16.1 7.8 0.0058 16.1 7.8 5.5 2 1 3 5 5 5 3 PT repeat Sod_Cu PF00080.20 ETO07228.1 - 0.01 16.0 0.0 0.06 13.5 0.0 2.2 1 1 0 1 1 1 0 Copper/zinc superoxide dismutase (SODC) eIF2A PF08662.11 ETO07229.1 - 0.049 13.5 0.0 0.11 12.4 0.0 1.6 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4529 PF15032.6 ETO07229.1 - 0.085 12.0 0.1 0.14 11.2 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4529) FH2 PF02181.23 ETO07230.1 - 3.7e-44 151.4 2.4 4.4e-44 151.1 2.4 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain H-K_ATPase_N PF09040.11 ETO07230.1 - 0.55 10.7 7.1 1.2 9.6 7.1 1.6 1 0 0 1 1 1 0 Gastric H+/K+-ATPase, N terminal domain VWA_2 PF13519.6 ETO07231.1 - 2.1e-11 44.4 0.1 6.7e-11 42.8 0.1 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO07231.1 - 8.5e-10 39.1 4.2 4.1e-09 36.9 4.2 2.1 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ETO07231.1 - 0.0017 17.8 0.1 0.017 14.5 0.0 2.1 2 0 0 2 2 2 1 VWA domain containing CoxE-like protein Ssl1 PF04056.14 ETO07233.1 - 1.1e-21 77.6 0.7 4.7e-20 72.2 0.7 2.1 1 1 0 1 1 1 1 Ssl1-like Adap_comp_sub PF00928.21 ETO07233.1 - 1.5e-05 24.6 0.1 4.5e-05 23.0 0.0 1.7 2 0 0 2 2 2 1 Adaptor complexes medium subunit family DUF5605 PF18310.1 ETO07235.1 - 0.032 14.1 0.0 0.49 10.3 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5605) Tcf25 PF04910.14 ETO07236.1 - 2.1 7.3 8.2 2.1 7.3 8.2 1.0 1 0 0 1 1 1 0 Transcriptional repressor TCF25 DUF4520 PF15016.6 ETO07236.1 - 3.5 7.8 7.7 0.55 10.4 3.5 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4520) Peptidase_C14 PF00656.22 ETO07240.1 - 3.7e-16 59.8 0.4 7.3e-16 58.9 0.4 1.5 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 ETO07241.1 - 6.6e-15 55.7 0.7 1e-14 55.1 0.7 1.2 1 0 0 1 1 1 1 Caspase domain NblA PF04485.12 ETO07241.1 - 0.008 16.6 0.3 0.03 14.7 0.1 2.1 2 0 0 2 2 2 1 Phycobilisome degradation protein nblA FAM76 PF16046.5 ETO07243.1 - 3 7.1 6.7 4.4 6.6 6.7 1.2 1 0 0 1 1 1 0 FAM76 protein PI3K_1B_p101 PF10486.9 ETO07243.1 - 3.9 5.1 9.0 0.58 7.9 5.3 1.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PTPRCAP PF15713.5 ETO07243.1 - 4 7.7 11.4 6.4 7.0 11.4 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated HSP70 PF00012.20 ETO07244.1 - 2.1e-85 287.1 0.0 1.3e-80 271.3 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein FGGY_C PF02782.16 ETO07244.1 - 0.0047 16.7 0.0 0.0072 16.1 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain PPR_2 PF13041.6 ETO07245.1 - 1.5e-10 41.1 3.8 2.5e-05 24.3 0.3 3.7 3 0 0 3 3 3 3 PPR repeat family PPR PF01535.20 ETO07245.1 - 2.6e-08 33.6 7.8 0.048 13.9 0.1 5.7 5 0 0 5 5 5 2 PPR repeat PPR_3 PF13812.6 ETO07245.1 - 0.00012 22.0 0.2 0.00012 22.0 0.2 3.6 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO07245.1 - 0.00084 18.8 0.7 0.00084 18.8 0.7 2.1 3 1 0 3 3 3 1 Pentacotripeptide-repeat region of PRORP ERM PF00769.19 ETO07246.1 - 0.019 14.8 17.8 0.027 14.3 17.8 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family NuDC PF16273.5 ETO07246.1 - 0.041 14.4 3.8 0.041 14.4 3.8 3.6 2 1 2 4 4 4 0 Nuclear distribution C domain ALMT PF11744.8 ETO07246.1 - 0.2 10.4 15.5 0.24 10.2 15.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 ETO07246.1 - 0.31 9.9 14.5 0.36 9.7 14.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Nop25 PF09805.9 ETO07246.1 - 0.57 10.7 21.6 0.47 10.9 20.5 1.4 1 1 0 1 1 1 0 Nucleolar protein 12 (25kDa) Fmp27_WPPW PF10359.9 ETO07246.1 - 0.63 8.8 21.4 0.79 8.5 21.4 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Golgin_A5 PF09787.9 ETO07246.1 - 2.5 7.5 19.6 0.13 11.7 11.6 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 5 PNISR PF15996.5 ETO07246.1 - 4.6 7.5 17.7 0.65 10.2 13.6 1.6 1 1 1 2 2 2 0 Arginine/serine-rich protein PNISR DUF3450 PF11932.8 ETO07246.1 - 6.6 6.0 10.7 0.25 10.6 5.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SR-25 PF10500.9 ETO07248.1 - 0.012 15.2 13.0 0.012 15.2 13.0 3.3 4 0 0 4 4 4 0 Nuclear RNA-splicing-associated protein RAB3GAP2_C PF14656.6 ETO07248.1 - 0.053 11.8 3.6 0.023 12.9 0.9 1.7 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit C-terminus SecY PF00344.20 ETO07249.1 - 8.7e-05 21.9 0.0 8.9e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 SecY translocase eRF1_2 PF03464.15 ETO07250.1 - 2.7e-25 89.2 0.2 4.3e-25 88.5 0.0 1.3 2 0 0 2 2 2 1 eRF1 domain 2 eRF1_3 PF03465.15 ETO07250.1 - 4.6e-13 49.6 0.0 9.2e-13 48.7 0.0 1.5 1 0 0 1 1 1 1 eRF1 domain 3 Ribosomal_L7Ae PF01248.26 ETO07250.1 - 0.012 15.3 0.0 0.024 14.4 0.0 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family DUF3388 PF11868.8 ETO07250.1 - 0.071 12.4 0.1 0.11 11.8 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3388) WD40 PF00400.32 ETO07251.1 - 3.9e-17 62.3 7.2 1.1e-05 26.0 0.2 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07251.1 - 0.00019 20.3 0.9 0.27 9.8 0.1 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07251.1 - 0.004 17.4 0.1 15 6.0 0.0 3.3 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Read-through PF16814.5 ETO07251.1 - 0.098 12.4 0.9 1.7 8.4 0.2 2.2 1 1 1 2 2 2 0 Read-through domain Melibiase_2 PF16499.5 ETO07252.1 - 3.2e-40 138.1 3.2 2e-39 135.5 3.2 1.9 1 1 0 1 1 1 1 Alpha galactosidase A TnpB_IS66 PF05717.13 ETO07254.1 - 0.027 14.4 0.0 0.052 13.5 0.0 1.5 1 0 0 1 1 1 0 IS66 Orf2 like protein DNA_photolyase PF00875.18 ETO07255.1 - 0.0025 17.8 0.1 0.0033 17.5 0.1 1.3 1 0 0 1 1 1 1 DNA photolyase DUF1664 PF07889.12 ETO07255.1 - 0.017 15.1 2.4 0.017 15.1 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ETO07255.1 - 0.088 13.2 3.7 0.79 10.2 1.6 2.5 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 ETO07255.1 - 0.19 12.2 1.7 2.2 8.8 1.7 2.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF5089 PF17002.5 ETO07255.1 - 0.2 11.5 8.1 0.26 11.2 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) UPF0242 PF06785.11 ETO07255.1 - 1 9.4 15.4 2 8.5 15.4 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF745 PF05335.13 ETO07255.1 - 1.5 8.5 5.7 0.31 10.7 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF745) NACHT PF05729.12 ETO07256.1 - 1.2e-09 38.3 0.0 2.3e-09 37.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO07256.1 - 8.7e-06 26.3 0.9 4.9e-05 23.9 0.0 2.1 1 1 1 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO07256.1 - 0.00098 19.4 0.5 0.006 16.9 0.2 2.3 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO07256.1 - 0.0045 17.4 0.3 0.056 13.8 0.1 2.4 1 1 1 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO07256.1 - 0.0062 16.4 0.9 0.024 14.6 0.1 2.2 1 1 0 2 2 2 1 RsgA GTPase TsaE PF02367.17 ETO07256.1 - 0.0064 16.5 0.0 0.02 14.9 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_2 PF03668.15 ETO07256.1 - 0.014 14.7 0.0 0.022 14.1 0.0 1.3 1 0 0 1 1 1 0 P-loop ATPase protein family Torsin PF06309.11 ETO07256.1 - 0.018 15.1 0.0 0.028 14.5 0.0 1.5 1 0 0 1 1 1 0 Torsin ABC_tran PF00005.27 ETO07256.1 - 0.021 15.3 0.4 0.048 14.2 0.4 1.7 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 ETO07256.1 - 0.025 14.6 0.0 0.078 13.0 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO07256.1 - 0.026 15.0 0.0 0.056 13.9 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ETO07256.1 - 0.038 14.4 2.3 0.059 13.8 0.1 2.5 2 1 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 ETO07256.1 - 0.046 13.4 0.0 0.079 12.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO07256.1 - 0.053 13.7 0.0 0.087 13.0 0.0 1.6 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ETO07256.1 - 0.063 13.0 0.1 0.23 11.2 0.0 1.9 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation PRK PF00485.18 ETO07256.1 - 0.07 12.9 0.1 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family ATP-synt_G PF04718.15 ETO07256.1 - 0.11 13.3 0.1 0.22 12.4 0.1 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase g subunit Sigma54_activat PF00158.26 ETO07256.1 - 0.13 11.9 0.0 0.26 11.0 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain FH2 PF02181.23 ETO07257.1 - 4.1e-23 82.1 3.6 4.8e-23 81.9 3.6 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Drf_FH1 PF06346.12 ETO07257.1 - 9.1 6.0 47.5 14 5.4 47.5 1.2 1 0 0 1 1 1 0 Formin Homology Region 1 EF-hand_6 PF13405.6 ETO07259.1 - 0.0024 17.6 0.6 0.0073 16.2 0.4 1.9 1 1 0 1 1 1 1 EF-hand domain IFT46_B_C PF12317.8 ETO07259.1 - 0.0027 17.5 1.4 0.0043 16.8 1.4 1.3 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal DUF4523 PF15023.6 ETO07259.1 - 0.12 12.2 0.1 0.18 11.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) Ras PF00071.22 ETO07260.1 - 1.2e-42 145.3 0.1 2.5e-42 144.2 0.1 1.5 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO07260.1 - 9.3e-27 93.6 0.1 2e-26 92.5 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO07260.1 - 9.3e-08 31.7 0.1 1.6e-07 31.0 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETO07260.1 - 0.0023 17.2 0.6 0.39 9.8 0.0 2.4 2 1 1 3 3 3 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ETO07260.1 - 0.0025 17.2 0.0 0.0038 16.6 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO07260.1 - 0.0045 17.1 0.1 0.0092 16.1 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO07260.1 - 0.0056 16.6 0.1 0.68 9.8 0.0 2.2 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 ETO07260.1 - 0.0095 15.2 0.6 0.014 14.6 0.1 1.5 2 0 0 2 2 2 1 Septin GTP_EFTU PF00009.27 ETO07260.1 - 0.019 14.5 0.1 0.034 13.7 0.1 1.4 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RNA_helicase PF00910.22 ETO07260.1 - 0.02 15.2 0.3 2.1 8.8 0.3 2.4 1 1 0 1 1 1 0 RNA helicase AAA_24 PF13479.6 ETO07260.1 - 0.05 13.3 0.3 0.09 12.5 0.3 1.4 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO07260.1 - 0.052 13.7 0.1 0.084 13.0 0.1 1.3 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 ETO07260.1 - 0.15 11.2 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 ETO07260.1 - 0.16 11.2 0.1 0.24 10.5 0.1 1.2 1 0 0 1 1 1 0 NB-ARC domain Mucin PF01456.17 ETO07261.1 - 0.019 15.0 12.7 0.019 15.0 12.7 1.4 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF1075 PF06388.11 ETO07261.1 - 0.054 13.5 0.5 0.1 12.7 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1075) MGC-24 PF05283.11 ETO07261.1 - 0.53 10.7 10.0 0.24 11.9 7.2 1.8 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SSP160 PF06933.11 ETO07261.1 - 0.78 7.9 8.6 1 7.5 8.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3437 PF11919.8 ETO07261.1 - 1 9.3 4.0 2.5 8.1 0.0 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF3437) DUF3439 PF11921.8 ETO07261.1 - 4.7 7.2 13.7 10 6.1 13.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FAS_N PF17828.1 ETO07262.1 - 0.019 15.0 0.2 0.035 14.1 0.2 1.4 1 0 0 1 1 1 0 N-terminal domain in fatty acid synthase subunit beta Ras PF00071.22 ETO07263.1 - 1.9e-53 180.4 2.1 8.8e-35 119.7 0.1 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO07263.1 - 3.7e-26 91.7 0.5 1.4e-13 51.1 0.3 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO07263.1 - 4.7e-12 45.7 0.3 1.2e-05 24.9 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO07263.1 - 0.011 15.8 0.2 0.04 14.0 0.1 2.1 2 1 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO07263.1 - 0.016 14.8 0.0 0.17 11.4 0.0 2.2 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO07263.1 - 0.022 14.7 0.0 3.6 7.4 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase AAA_24 PF13479.6 ETO07263.1 - 0.03 14.0 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ETO07263.1 - 0.076 12.9 0.9 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea MCM PF00493.23 ETO07263.1 - 0.076 12.1 0.1 0.12 11.4 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_16 PF13191.6 ETO07263.1 - 0.09 13.2 0.0 0.39 11.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETO07263.1 - 0.14 12.4 0.0 0.51 10.6 0.0 1.9 2 1 0 2 2 2 0 AAA domain WD40 PF00400.32 ETO07265.1 - 2.5e-10 40.8 11.4 3.6e-07 30.8 0.3 2.7 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07265.1 - 0.00089 19.5 0.0 0.0015 18.7 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07265.1 - 0.0027 17.1 0.4 0.0033 16.8 0.4 1.3 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO07265.1 - 0.007 15.1 1.1 0.064 11.9 0.0 2.0 1 1 1 2 2 2 1 Nucleoporin Nup120/160 AF0941-like PF14591.6 ETO07266.1 - 0.014 16.0 1.6 0.015 15.9 1.6 1.1 1 0 0 1 1 1 0 AF0941-like DUF3288 PF11691.8 ETO07266.1 - 0.02 14.9 0.6 0.022 14.8 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3288) DUF4953 PF16313.5 ETO07266.1 - 0.029 13.6 1.7 0.034 13.4 1.7 1.0 1 0 0 1 1 1 0 Met-zincin DUF4085 PF13315.6 ETO07266.1 - 0.05 13.2 2.4 0.048 13.3 2.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) Mistic PF11458.8 ETO07266.1 - 0.44 10.6 5.7 0.37 10.8 0.6 2.0 1 1 1 2 2 2 0 Membrane-integrating protein Mistic WD40 PF00400.32 ETO07267.1 - 9.5e-33 111.7 24.3 6.9e-06 26.7 0.6 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07267.1 - 6.6e-10 39.1 2.1 0.045 14.1 0.0 5.3 3 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07267.1 - 2.9e-07 29.5 7.9 0.0031 16.2 1.1 4.3 1 1 4 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07267.1 - 3.4e-07 29.9 13.7 0.015 14.6 0.5 4.9 2 2 4 6 6 6 3 WD40-like domain AAA_5 PF07728.14 ETO07269.1 - 3.6e-07 30.3 0.0 6e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ETO07269.1 - 0.067 13.1 0.0 0.087 12.7 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Hep_59 PF07052.11 ETO07270.1 - 3e-06 27.9 0.7 3e-06 27.9 0.7 2.7 2 1 1 3 3 3 1 Hepatocellular carcinoma-associated antigen 59 Macoilin PF09726.9 ETO07270.1 - 2.2 6.7 9.0 2.4 6.6 9.0 1.0 1 0 0 1 1 1 0 Macoilin family DUF755 PF05501.11 ETO07270.1 - 5.7 7.2 13.2 0.1 12.8 6.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF3810 PF12725.7 ETO07271.1 - 0.12 11.8 0.3 0.12 11.7 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Mo25 PF08569.11 ETO07272.1 - 0.00086 18.8 3.6 0.0012 18.3 3.6 1.2 1 0 0 1 1 1 1 Mo25-like DUF3447 PF11929.8 ETO07272.1 - 0.05 13.6 0.3 0.14 12.1 0.3 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3447) CagE_TrbE_VirB PF03135.14 ETO07272.1 - 0.052 13.6 1.0 0.099 12.7 1.0 1.5 1 1 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system PIN_4 PF13638.6 ETO07272.1 - 0.15 12.3 1.4 0.22 11.8 0.4 1.7 2 0 0 2 2 2 0 PIN domain Kelch_1 PF01344.25 ETO07273.1 - 1.3e-21 75.9 3.1 3.5e-06 26.5 0.0 5.5 5 1 0 5 5 5 4 Kelch motif Kelch_6 PF13964.6 ETO07273.1 - 1.8e-15 56.6 6.5 0.002 18.4 0.0 5.2 3 2 2 5 5 5 4 Kelch motif Kelch_2 PF07646.15 ETO07273.1 - 9.3e-09 34.9 5.6 0.0096 15.9 0.0 5.4 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO07273.1 - 9e-07 28.8 6.0 0.94 9.5 0.1 5.6 5 2 0 5 5 5 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO07273.1 - 2.3e-06 27.5 0.1 0.0012 18.8 0.0 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO07273.1 - 0.0002 21.6 0.6 0.83 10.0 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain GDP_Man_Dehyd PF16363.5 ETO07274.1 - 1.5e-47 162.7 0.0 4.7e-47 161.0 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETO07274.1 - 3.9e-41 141.1 0.0 8.8e-41 139.9 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO07274.1 - 8.9e-10 38.0 0.0 1.2e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ETO07274.1 - 1e-09 38.0 0.0 6.9e-05 22.1 0.0 2.3 2 0 0 2 2 2 2 Male sterility protein Polysacc_synt_2 PF02719.15 ETO07274.1 - 4.5e-06 26.0 0.3 0.00028 20.1 0.2 2.9 2 2 0 2 2 2 1 Polysaccharide biosynthesis protein adh_short PF00106.25 ETO07274.1 - 0.0017 17.9 0.0 0.0028 17.1 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase RmlD_sub_bind PF04321.17 ETO07274.1 - 0.0045 16.1 0.0 0.009 15.1 0.0 1.4 1 1 0 1 1 1 1 RmlD substrate binding domain KR PF08659.10 ETO07274.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.5 2 0 0 2 2 2 0 KR domain ADP_ribosyl_GH PF03747.14 ETO07275.1 - 1.8e-32 113.3 0.0 2.8e-32 112.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Rer1 PF03248.13 ETO07275.1 - 0.062 13.0 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Rer1 family SPOUT_MTase PF02590.17 ETO07275.1 - 0.41 10.6 2.9 1.5 8.8 0.5 2.2 2 0 0 2 2 2 0 Predicted SPOUT methyltransferase CLN3 PF02487.17 ETO07275.1 - 0.45 9.5 2.7 0.68 8.9 0.1 2.0 2 0 0 2 2 2 0 CLN3 protein MscL PF01741.18 ETO07275.1 - 0.87 9.9 4.7 0.21 11.9 0.7 2.0 3 0 0 3 3 3 0 Large-conductance mechanosensitive channel, MscL RP-C_C PF11800.8 ETO07275.1 - 5.1 7.1 8.0 0.75 9.9 3.5 1.7 2 0 0 2 2 2 0 Replication protein C C-terminal region Conotoxin PF02950.17 ETO07275.1 - 7.2 7.7 6.3 7.8 7.6 0.0 3.2 3 1 1 4 4 4 0 Conotoxin Afi1 PF07792.12 ETO07275.1 - 8.2 6.9 13.4 1.1 9.7 1.2 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDT1 PF08839.11 ETO07276.1 - 3e-18 66.7 5.7 2.2e-17 63.9 5.7 2.1 1 1 0 1 1 1 1 DNA replication factor CDT1 like Pox_Ag35 PF03286.14 ETO07276.1 - 1.4e-06 28.2 2.9 1.4e-06 28.2 2.9 1.6 2 0 0 2 2 2 1 Pox virus Ag35 surface protein Presenilin PF01080.17 ETO07276.1 - 0.27 9.9 5.4 0.55 8.9 5.4 1.5 1 0 0 1 1 1 0 Presenilin SDA1 PF05285.12 ETO07276.1 - 1.3 8.4 12.7 2.2 7.6 12.8 1.3 1 1 0 1 1 1 0 SDA1 NIF PF03031.18 ETO07277.1 - 3.6e-29 101.5 0.2 1.5e-21 76.8 0.0 2.1 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase HAD PF12710.7 ETO07277.1 - 0.00062 20.2 0.0 0.0011 19.4 0.0 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase CDC45 PF02724.14 ETO07279.1 - 0.48 8.7 12.6 0.69 8.1 12.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO07279.1 - 8.6 4.6 10.4 13 4.0 10.4 1.2 1 0 0 1 1 1 0 Menin RdRP PF05183.12 ETO07280.1 - 7.9e-34 117.3 0.7 8e-18 64.4 0.1 2.4 2 1 1 3 3 3 2 RNA dependent RNA polymerase Peripla_BP_2 PF01497.18 ETO07281.1 - 0.063 12.8 0.0 0.091 12.3 0.0 1.2 1 0 0 1 1 1 0 Periplasmic binding protein DUF1298 PF06974.13 ETO07282.1 - 8.5e-08 32.3 0.0 1.3e-05 25.2 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF1298) SDA1 PF05285.12 ETO07282.1 - 8.7e-05 22.1 8.5 0.0001 21.8 8.5 1.1 1 0 0 1 1 1 1 SDA1 Sporozoite_P67 PF05642.11 ETO07282.1 - 0.014 13.5 2.3 0.018 13.1 2.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM60A PF15396.6 ETO07282.1 - 0.033 14.2 3.4 0.053 13.5 3.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A DUF2457 PF10446.9 ETO07282.1 - 0.13 11.4 24.5 0.18 11.0 24.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SAPS PF04499.15 ETO07282.1 - 0.37 9.5 8.7 0.5 9.1 8.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO07282.1 - 0.58 8.4 17.0 0.8 7.9 17.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.6 ETO07282.1 - 3.1 6.4 5.2 4.3 6.0 5.2 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 ETO07282.1 - 5.5 5.7 8.6 7.6 5.2 8.6 1.1 1 0 0 1 1 1 0 Presenilin eIF-3c_N PF05470.12 ETO07282.1 - 9.1 4.5 15.9 13 3.9 15.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PfkB PF00294.24 ETO07283.1 - 1.2e-19 70.8 0.0 9.6e-08 31.7 0.0 3.2 3 0 0 3 3 3 3 pfkB family carbohydrate kinase CRAL_TRIO PF00650.20 ETO07287.1 - 0.087 12.5 4.4 2.3 7.9 1.0 2.8 1 1 1 2 2 2 0 CRAL/TRIO domain Pept_tRNA_hydro PF01195.19 ETO07288.1 - 0.007 16.4 0.0 0.01 15.8 0.0 1.2 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase DUF3546 PF12066.8 ETO07288.1 - 0.011 16.0 1.5 0.011 16.0 1.5 2.2 1 1 2 3 3 3 0 Domain of unknown function (DUF3546) SDP_N PF12278.8 ETO07288.1 - 0.052 13.7 0.6 0.086 13.0 0.6 1.3 1 0 0 1 1 1 0 Sex determination protein N terminal APC_N_CC PF16689.5 ETO07288.1 - 0.11 12.6 10.3 0.19 11.8 1.0 3.6 3 1 1 4 4 4 0 Coiled-coil N-terminus of APC, dimerisation domain Oxidored_q3 PF00499.20 ETO07290.1 - 0.0034 17.1 9.4 0.014 15.1 8.8 2.1 2 1 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF2721 PF11026.8 ETO07290.1 - 0.02 14.8 0.8 0.02 14.8 0.8 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) EF-hand_1 PF00036.32 ETO07290.1 - 0.073 12.6 0.0 0.22 11.2 0.0 1.9 1 0 0 1 1 1 0 EF hand DUF4769 PF15992.5 ETO07290.1 - 0.16 11.8 3.8 0.29 10.9 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) DUF2981 PF11200.8 ETO07290.1 - 0.29 10.8 6.3 0.75 9.5 6.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2981) Tir_receptor_C PF07489.11 ETO07290.1 - 2.4 8.1 10.2 4.2 7.3 10.2 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus FA_desaturase PF00487.24 ETO07290.1 - 2.6 7.8 4.3 4 7.2 4.1 1.4 1 1 0 1 1 1 0 Fatty acid desaturase RR_TM4-6 PF06459.12 ETO07290.1 - 5.7 6.7 8.8 7 6.4 0.3 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FSA_C PF10479.9 ETO07290.1 - 6.5 4.8 9.8 10 4.1 9.8 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Thia_YuaJ PF09515.10 ETO07291.1 - 0.001 19.1 0.1 0.001 19.1 0.1 1.6 2 0 0 2 2 2 1 Thiamine transporter protein (Thia_YuaJ) Oxidored_q3 PF00499.20 ETO07291.1 - 0.0013 18.5 7.0 0.0021 17.8 5.7 1.9 2 1 0 2 2 2 1 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF3439 PF11921.8 ETO07291.1 - 0.013 15.4 4.3 0.026 14.5 4.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2981 PF11200.8 ETO07291.1 - 0.016 15.0 0.1 0.023 14.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF2721 PF11026.8 ETO07291.1 - 0.019 14.9 0.5 0.019 14.9 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) DUF2207 PF09972.9 ETO07291.1 - 0.23 10.2 3.3 0.061 12.1 0.2 1.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) CALM_bind PF16025.5 ETO07292.1 - 0.0016 18.9 0.7 0.0036 17.7 0.0 1.8 2 0 0 2 2 2 1 Calcium-dependent calmodulin binding Dicty_REP PF05086.12 ETO07292.1 - 0.0016 16.5 3.0 0.0016 16.5 3.0 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein fn3 PF00041.21 ETO07293.1 - 0.026 14.9 0.7 0.17 12.2 0.7 2.5 1 1 0 1 1 1 0 Fibronectin type III domain Cyt-b5 PF00173.28 ETO07294.1 - 4.7e-08 33.1 0.0 6.8e-07 29.3 0.0 2.4 1 1 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain TTL PF03133.15 ETO07296.1 - 7.1e-23 81.2 2.1 5.3e-19 68.5 0.7 2.1 2 0 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ETO07296.1 - 6.2e-05 22.4 0.0 0.0048 16.2 0.0 2.3 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ETO07296.1 - 0.05 12.8 0.0 0.52 9.5 0.0 2.1 2 0 0 2 2 2 0 Sugar-transfer associated ATP-grasp Abhydrolase_2 PF02230.16 ETO07297.1 - 5.3e-25 88.5 0.3 6e-22 78.5 0.2 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Esterase_phd PF10503.9 ETO07297.1 - 2.4e-05 23.9 0.0 3.9e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Esterase PHB depolymerase Hydrolase_4 PF12146.8 ETO07297.1 - 5e-05 22.7 0.2 0.19 10.9 0.1 2.7 2 1 1 3 3 3 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO07297.1 - 0.00075 19.2 0.0 0.0081 15.8 0.1 2.1 1 1 1 2 2 2 1 alpha/beta hydrolase fold Esterase PF00756.20 ETO07297.1 - 0.00087 19.0 0.0 0.0011 18.7 0.0 1.3 1 0 0 1 1 1 1 Putative esterase DLH PF01738.18 ETO07297.1 - 0.0011 18.6 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family FSH1 PF03959.13 ETO07297.1 - 0.0011 18.6 1.1 0.0022 17.7 0.1 1.9 2 0 0 2 2 2 1 Serine hydrolase (FSH1) AXE1 PF05448.12 ETO07297.1 - 0.0012 17.6 0.0 0.002 16.8 0.0 1.3 1 0 0 1 1 1 1 Acetyl xylan esterase (AXE1) Peptidase_S9 PF00326.21 ETO07297.1 - 0.018 14.5 0.1 3.7 7.0 0.1 2.2 1 1 1 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ETO07297.1 - 0.11 12.4 0.0 0.98 9.2 0.0 2.2 1 1 0 1 1 1 0 alpha/beta hydrolase fold Beach PF02138.18 ETO07298.1 - 3e-116 387.6 0.0 4.8e-116 387.0 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH PF00169.29 ETO07298.1 - 9.9e-06 26.0 0.9 2.4e-05 24.8 0.9 1.7 1 0 0 1 1 1 1 PH domain TOPRIM_C PF16898.5 ETO07298.1 - 0.0034 17.7 0.5 0.0095 16.2 0.5 1.8 1 0 0 1 1 1 1 C-terminal associated domain of TOPRIM PH_6 PF15406.6 ETO07298.1 - 0.071 13.4 0.1 0.66 10.3 0.0 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain SWIRM PF04433.17 ETO07298.1 - 0.096 13.0 0.3 0.7 10.3 0.1 2.5 2 0 0 2 2 2 0 SWIRM domain PH_BEACH PF14844.6 ETO07298.1 - 0.11 12.6 3.4 0.16 12.1 0.0 2.9 4 0 0 4 4 4 0 PH domain associated with Beige/BEACH RhoGAP-FF1 PF16512.5 ETO07299.1 - 0.012 16.2 0.3 0.32 11.7 0.0 2.8 2 0 0 2 2 2 0 p190-A and -B Rho GAPs FF domain RIG-I_C PF18119.1 ETO07300.1 - 0.013 15.6 1.4 0.02 14.9 1.4 1.4 1 1 0 1 1 1 0 RIG-I receptor C-terminal domain EF-hand_2 PF09068.11 ETO07300.1 - 0.032 14.4 0.4 0.056 13.6 0.3 1.5 1 1 0 1 1 1 0 EF hand Kelch_5 PF13854.6 ETO07301.1 - 0.0024 17.8 4.3 0.11 12.5 1.7 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO07301.1 - 0.0026 17.3 3.6 0.041 13.5 0.4 3.7 4 1 0 4 4 4 1 Kelch motif PHTB1_N PF14727.6 ETO07301.1 - 0.013 14.9 1.1 2.1 7.6 0.1 2.5 2 1 1 3 3 3 0 PTHB1 N-terminus Kelch_6 PF13964.6 ETO07301.1 - 0.025 14.9 3.9 1.6 9.1 0.1 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_3 PF13415.6 ETO07301.1 - 0.033 14.5 1.4 0.078 13.3 0.1 2.5 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07301.1 - 0.22 11.5 0.9 2.4 8.3 0.1 3.2 3 0 0 3 3 3 0 Kelch motif DivIC PF04977.15 ETO07303.1 - 0.0046 16.7 3.4 0.0046 16.7 3.4 2.9 2 1 0 2 2 2 1 Septum formation initiator Atg14 PF10186.9 ETO07303.1 - 0.015 14.4 13.8 0.02 14.0 13.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 XLF PF09302.11 ETO07303.1 - 0.033 14.3 1.9 0.033 14.3 1.9 2.3 1 1 0 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Bap31_Bap29_C PF18035.1 ETO07303.1 - 0.077 13.0 0.2 0.077 13.0 0.2 4.0 3 1 0 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain Exonuc_VII_L PF02601.15 ETO07303.1 - 0.2 11.2 10.2 0.26 10.8 10.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit PIN7 PF18475.1 ETO07303.1 - 0.3 11.7 2.5 2.7 8.7 0.3 2.5 2 1 0 2 2 2 0 PIN domain RP-C PF03428.13 ETO07303.1 - 0.47 10.1 5.9 1 9.0 1.1 2.3 1 1 0 2 2 2 0 Replication protein C N-terminal domain Noelin-1 PF12308.8 ETO07303.1 - 1.7 8.6 13.0 2.6 8.1 3.8 2.3 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF641 PF04859.12 ETO07303.1 - 3.1 8.1 14.6 0.21 11.9 6.3 2.6 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Spc7 PF08317.11 ETO07303.1 - 3.5 6.4 23.8 6.9 5.5 23.8 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein ORF6C PF10552.9 ETO07303.1 - 3.5 7.7 15.8 0.057 13.5 5.4 2.1 1 1 1 2 2 2 0 ORF6C domain UPF0242 PF06785.11 ETO07303.1 - 3.6 7.7 24.4 5.1 7.1 23.6 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 ETO07303.1 - 4.4 7.5 21.8 0.12 12.5 8.8 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Csm1_N PF18504.1 ETO07303.1 - 4.6 7.6 20.5 0.13 12.6 7.5 3.2 2 2 1 3 3 3 0 Csm1 N-terminal domain DUF848 PF05852.11 ETO07303.1 - 5.2 7.2 14.7 2 8.5 7.8 2.3 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) O-antigen_lig PF13425.6 ETO07303.1 - 5.3 5.7 6.1 6.5 5.4 6.1 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4140 PF13600.6 ETO07303.1 - 8.6 6.9 8.9 0.87 10.1 1.5 2.4 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) SpoIIIAH PF12685.7 ETO07304.1 - 2 8.2 16.5 0.17 11.7 11.9 1.4 2 0 0 2 2 2 0 SpoIIIAH-like protein FTZ PF03867.14 ETO07304.1 - 5.4 6.5 11.2 8.9 5.8 11.2 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DUF3826 PF12875.7 ETO07305.1 - 0.012 15.8 1.4 0.016 15.4 0.6 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3826) DUF3685 PF12452.8 ETO07305.1 - 0.059 13.1 0.2 0.075 12.7 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) Kinesin PF00225.23 ETO07306.1 - 2.4e-25 89.2 0.6 3e-13 49.4 0.0 2.6 2 1 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 ETO07306.1 - 6.6e-11 42.4 0.0 1.5e-10 41.2 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding NID PF07292.13 ETO07308.1 - 0.018 15.7 0.1 0.022 15.4 0.1 1.3 1 0 0 1 1 1 0 Nmi/IFP 35 domain (NID) End3 PF12761.7 ETO07309.1 - 0.18 12.0 7.3 0.23 11.6 7.3 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 BSP_II PF05432.11 ETO07309.1 - 0.54 9.9 8.8 0.66 9.6 8.8 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Kelch_2 PF07646.15 ETO07310.1 - 1.1e-07 31.6 1.7 0.0026 17.7 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO07310.1 - 1.4e-07 31.6 4.1 0.0014 18.9 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO07310.1 - 4.4e-06 26.2 2.6 0.0051 16.4 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO07310.1 - 2.2e-05 24.6 0.1 0.002 18.4 0.0 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO07310.1 - 0.0002 21.3 8.7 1.4 9.0 1.4 5.2 4 1 1 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETO07310.1 - 0.00038 20.4 0.9 0.0046 16.9 0.1 2.8 2 1 1 3 3 3 1 Galactose oxidase, central domain RhoGAP-FF1 PF16512.5 ETO07310.1 - 0.011 16.4 0.2 0.035 14.8 0.2 1.9 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain zf-RNPHF PF08080.12 ETO07310.1 - 0.059 13.3 0.0 0.21 11.6 0.0 2.0 1 0 0 1 1 1 0 RNPHF zinc finger Peptidase_C14 PF00656.22 ETO07311.1 - 3.1e-05 24.0 0.1 3.9e-05 23.7 0.1 1.1 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO07312.1 - 0.13 12.2 3.1 0.82 9.7 0.1 3.0 4 0 0 4 4 4 0 Kelch motif Josephin PF02099.17 ETO07312.1 - 0.41 10.7 5.6 1.3 9.1 5.6 2.1 1 1 0 1 1 1 0 Josephin WD40 PF00400.32 ETO07313.1 - 7.5e-59 194.3 17.3 3.9e-11 43.3 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07313.1 - 1.5e-17 63.7 0.3 0.00022 21.4 0.0 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07313.1 - 2.7e-12 46.3 0.7 0.0033 16.4 0.0 5.8 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO07313.1 - 3.9e-09 36.7 0.0 2.7e-05 24.1 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO07313.1 - 6.9e-07 28.3 6.1 0.77 8.3 0.1 5.0 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07313.1 - 4.5e-06 26.2 0.5 0.45 9.8 0.0 3.1 2 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO07313.1 - 0.00047 18.8 0.3 0.18 10.3 0.1 3.0 2 1 0 3 3 3 1 Cytochrome D1 heme domain DUF2218 PF09981.9 ETO07313.1 - 0.00069 19.9 0.0 0.0032 17.8 0.0 2.0 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2218) BBS2_Mid PF14783.6 ETO07313.1 - 0.0034 17.4 0.3 0.24 11.5 0.1 3.4 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 ETO07313.1 - 0.013 15.4 6.6 14 5.8 0.0 5.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Methyltransf_3 PF01596.17 ETO07313.1 - 0.026 13.7 0.0 0.23 10.6 0.0 2.2 3 0 0 3 3 3 0 O-methyltransferase PQQ PF01011.21 ETO07313.1 - 0.052 13.5 0.0 12 6.0 0.0 3.3 3 0 0 3 3 3 0 PQQ enzyme repeat Coat_X PF07552.11 ETO07313.1 - 0.93 9.4 5.1 1.9 8.4 0.0 3.2 4 0 0 4 4 4 0 Spore Coat Protein X and V domain CH PF00307.31 ETO07314.1 - 9.9e-11 41.8 0.1 9.9e-11 41.8 0.1 2.5 3 0 0 3 3 3 1 Calponin homology (CH) domain Pox_A_type_inc PF04508.12 ETO07314.1 - 4.2e-05 23.2 2.1 0.095 12.6 0.3 2.9 2 0 0 2 2 2 2 Viral A-type inclusion protein repeat BRE1 PF08647.11 ETO07314.1 - 0.008 16.2 17.0 0.4 10.8 5.9 2.4 1 1 1 2 2 2 2 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 ETO07314.1 - 0.0088 16.1 15.7 0.013 15.6 11.6 2.2 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 ETO07314.1 - 0.018 15.5 16.8 0.044 14.2 11.3 2.3 1 1 1 2 2 2 0 Fez1 DUF1961 PF09224.11 ETO07314.1 - 0.066 12.6 0.0 0.12 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1961) THOC7 PF05615.13 ETO07314.1 - 0.13 12.5 13.7 0.74 10.1 12.1 2.4 2 1 1 3 3 3 0 Tho complex subunit 7 AAA_11 PF13086.6 ETO07314.1 - 0.23 11.2 5.5 0.3 10.8 5.5 1.2 1 0 0 1 1 1 0 AAA domain BST2 PF16716.5 ETO07314.1 - 0.25 12.0 13.7 0.37 11.4 11.1 2.5 2 1 1 3 3 3 0 Bone marrow stromal antigen 2 Mit_KHE1 PF10173.9 ETO07314.1 - 0.27 11.3 4.3 0.49 10.5 4.3 1.5 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related FAM76 PF16046.5 ETO07314.1 - 0.31 10.3 9.1 0.39 10.0 9.1 1.2 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 ETO07314.1 - 0.51 9.7 5.8 0.71 9.2 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ETO07314.1 - 0.78 9.3 5.2 0.8 9.2 5.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3450 PF11932.8 ETO07314.1 - 0.95 8.7 14.3 3.1 7.0 5.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Phage_GPO PF05929.11 ETO07314.1 - 1.1 8.8 8.1 1.6 8.3 8.1 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Csm1_N PF18504.1 ETO07314.1 - 1.7 9.0 13.2 0.63 10.4 0.9 3.0 1 1 2 3 3 3 0 Csm1 N-terminal domain DUF5320 PF17253.2 ETO07314.1 - 1.9 9.6 8.5 6.4 7.9 1.6 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5320) Rho_Binding PF08912.11 ETO07314.1 - 2.9 8.8 17.3 1.5 9.7 3.3 3.3 1 1 1 2 2 2 0 Rho Binding DUF883 PF05957.13 ETO07314.1 - 8.1 7.1 6.6 19 6.0 0.3 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) WD40 PF00400.32 ETO07315.1 - 1.1e-15 57.7 8.6 6.3e-05 23.7 1.9 4.9 5 1 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07315.1 - 0.00033 19.4 1.0 2.2 6.9 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07315.1 - 0.0013 18.9 0.3 4.2 7.7 0.0 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3043 PF11241.8 ETO07316.1 - 0.61 10.1 4.7 1 9.4 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Apq12 PF12716.7 ETO07316.1 - 4.9 7.2 13.0 1.4 8.9 9.8 1.8 2 0 0 2 2 2 0 Nuclear pore assembly and biogenesis WD40 PF00400.32 ETO07317.1 - 2e-24 85.4 11.6 3.6e-06 27.6 0.5 6.0 5 3 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07317.1 - 1.2e-08 35.2 0.3 0.05 13.9 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07317.1 - 4.8e-07 28.8 1.7 0.49 9.0 0.0 3.9 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO07317.1 - 0.037 12.8 4.2 1.8 7.2 0.1 2.7 1 1 1 2 2 2 0 Nup133 N terminal like DUF3915 PF13054.6 ETO07317.1 - 0.085 12.8 1.0 0.12 12.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Com_YlbF PF06133.11 ETO07318.1 - 0.053 14.1 3.3 0.084 13.5 3.3 1.2 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA WD40 PF00400.32 ETO07319.1 - 1.3e-14 54.4 8.5 1.4e-07 32.1 0.7 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO07319.1 - 1.9e-05 23.6 0.7 0.002 16.8 0.1 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Tektin PF03148.14 ETO07319.1 - 0.027 13.2 4.3 0.025 13.3 2.9 1.5 1 1 1 2 2 2 0 Tektin family YabA PF06156.13 ETO07319.1 - 0.056 14.1 6.4 0.14 12.8 5.6 2.0 1 1 0 1 1 1 0 Initiation control protein YabA Laminin_II PF06009.12 ETO07319.1 - 0.099 12.7 6.1 0.15 12.0 6.1 1.3 1 0 0 1 1 1 0 Laminin Domain II LIN52 PF10044.9 ETO07319.1 - 0.11 13.2 0.7 0.23 12.2 0.5 1.7 1 1 0 1 1 1 0 Retinal tissue protein CENP-F_leu_zip PF10473.9 ETO07319.1 - 0.14 12.2 9.3 0.2 11.7 9.3 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 ETO07319.1 - 0.2 11.9 5.5 0.29 11.3 5.5 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 WD40 PF00400.32 ETO07320.1 - 1.1e-07 32.4 4.8 0.039 14.8 0.7 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07320.1 - 0.054 13.8 0.2 0.1 12.9 0.2 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO07321.1 - 1.8e-18 66.5 7.3 8.2e-06 26.5 0.2 4.4 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07321.1 - 0.00012 22.3 0.3 7.4 7.0 0.0 3.3 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07321.1 - 0.017 13.8 0.2 0.25 9.9 0.0 2.3 1 1 2 3 3 3 0 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO07321.1 - 0.042 14.1 0.3 1.1 9.4 0.1 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO07322.1 - 5.1e-38 128.4 25.3 7.5e-07 29.8 0.5 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07322.1 - 4e-10 39.8 3.4 0.017 15.4 0.0 5.4 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07322.1 - 6.6e-09 35.0 6.8 0.18 10.4 0.0 5.1 1 1 4 5 5 5 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO07322.1 - 0.00012 21.0 7.1 0.018 13.8 0.9 3.1 1 1 1 3 3 3 2 Nup133 N terminal like ABC2_membrane_3 PF12698.7 ETO07323.1 - 0.00096 18.3 1.8 0.0011 18.2 1.8 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein PgaPase_1 PF06162.12 ETO07323.1 - 0.021 14.6 1.6 0.03 14.1 1.6 1.2 1 0 0 1 1 1 0 Putative pyroglutamyl peptidase PgaPase_1 Sld7_N PF18636.1 ETO07323.1 - 0.087 13.2 1.7 0.11 12.8 1.7 1.3 1 1 0 1 1 1 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain Sulfatase PF00884.23 ETO07324.1 - 1e-49 169.6 4.4 1.4e-49 169.1 4.4 1.2 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ETO07324.1 - 3e-07 30.4 3.7 7.8e-07 29.0 3.7 1.6 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 ETO07324.1 - 0.00041 21.1 1.8 0.0021 18.8 1.8 2.1 1 1 0 1 1 1 1 C-terminal region of aryl-sulfatase LUC7 PF03194.15 ETO07324.1 - 0.21 11.3 0.1 0.41 10.3 0.1 1.4 1 0 0 1 1 1 0 LUC7 N_terminus PAW PF04721.17 ETO07325.1 - 3.7e-05 23.6 1.1 0.00011 22.0 0.3 1.9 2 0 0 2 2 2 1 PNGase C-terminal domain, mannose-binding module PAW DUF5439 PF17507.2 ETO07325.1 - 2.2 8.6 5.0 2.9 8.2 2.6 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5439) Ribosomal_S24e PF01282.19 ETO07326.1 - 0.11 12.4 0.8 28 4.7 0.0 3.1 3 1 0 3 3 3 0 Ribosomal protein S24e TBK1_ULD PF18396.1 ETO07326.1 - 0.22 11.4 0.0 0.22 11.4 0.0 2.3 2 1 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain WD40 PF00400.32 ETO07328.1 - 2.3e-09 37.7 2.4 0.00074 20.3 0.0 4.3 5 0 0 5 5 5 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO07328.1 - 0.0033 16.1 0.0 2.3 6.8 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07328.1 - 0.013 15.8 0.0 12 6.3 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Thioredoxin_11 PF18078.1 ETO07328.1 - 0.025 14.7 0.1 0.37 10.9 0.1 2.1 2 0 0 2 2 2 0 Thioredoxin-like SNTX domain BSD PF03909.17 ETO07330.1 - 3.8e-08 33.2 1.5 1.4e-06 28.2 0.4 2.6 2 0 0 2 2 2 1 BSD domain EF-hand_7 PF13499.6 ETO07330.1 - 0.0028 18.1 2.2 0.53 10.8 0.0 3.4 3 1 1 4 4 4 2 EF-hand domain pair dDENN PF03455.19 ETO07330.1 - 0.029 14.3 0.1 0.081 12.9 0.1 1.7 1 0 0 1 1 1 0 dDENN domain EF-hand_5 PF13202.6 ETO07330.1 - 0.04 13.4 0.1 0.3 10.6 0.1 2.4 2 0 0 2 2 2 0 EF hand DUF572 PF04502.13 ETO07330.1 - 2.4 7.7 10.5 4.1 6.9 10.5 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF572) TTL PF03133.15 ETO07331.1 - 0.0066 15.6 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family Tubulin_C PF03953.17 ETO07332.1 - 0.065 13.4 0.3 0.087 13.0 0.3 1.1 1 0 0 1 1 1 0 Tubulin C-terminal domain UPF0270 PF06794.12 ETO07332.1 - 0.14 12.2 0.2 6.9 6.8 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0270) Sina PF03145.16 ETO07335.1 - 2.4e-05 24.4 2.3 2.4e-05 24.4 2.3 2.3 2 0 0 2 2 2 1 Seven in absentia protein family zf-TRAF PF02176.18 ETO07335.1 - 0.00011 22.9 2.8 0.00011 22.9 2.8 3.0 1 1 2 3 3 3 1 TRAF-type zinc finger zf-C3HC4_3 PF13920.6 ETO07335.1 - 0.00032 20.5 14.6 0.00043 20.1 5.0 2.9 3 0 0 3 3 3 2 Zinc finger, C3HC4 type (RING finger) Gin PF10764.9 ETO07335.1 - 0.0038 17.1 6.4 0.0038 17.1 6.4 2.1 2 0 0 2 2 2 1 Inhibitor of sigma-G Gin GNAT_acetyltr_2 PF13718.6 ETO07335.1 - 0.018 14.5 1.5 0.024 14.0 0.2 1.8 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Prok-RING_4 PF14447.6 ETO07335.1 - 0.21 11.4 9.4 3.7 7.5 0.2 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 GWT1 PF06423.12 ETO07335.1 - 0.24 11.5 1.3 0.44 10.7 0.2 2.0 2 0 0 2 2 2 0 GWT1 zf-C3HC4 PF00097.25 ETO07335.1 - 3.7 7.5 11.1 39 4.2 11.1 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO07335.1 - 5.5 7.0 12.6 29 4.7 12.8 2.2 1 1 0 1 1 1 0 zinc-RING finger domain G-patch_2 PF12656.7 ETO07336.1 - 1.2e-13 51.0 0.2 1.2e-13 51.0 0.2 2.2 2 0 0 2 2 2 1 G-patch domain KN17_SH3 PF18131.1 ETO07336.1 - 2e-06 27.8 0.0 1.1e-05 25.5 0.0 2.1 2 0 0 2 2 2 1 KN17 SH3-like C-terminal domain KOW PF00467.29 ETO07336.1 - 0.00022 21.1 0.1 0.00091 19.1 0.0 2.0 2 0 0 2 2 2 1 KOW motif G-patch PF01585.23 ETO07336.1 - 0.021 14.7 2.4 0.04 13.8 1.2 2.1 2 1 0 2 2 2 0 G-patch domain SR-25 PF10500.9 ETO07336.1 - 4.2 6.9 21.6 4 7.0 5.7 2.5 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DEK_C PF08766.11 ETO07337.1 - 0.00042 20.2 0.0 0.00092 19.1 0.0 1.6 1 0 0 1 1 1 1 DEK C terminal domain MMR1 PF08505.10 ETO07337.1 - 0.057 13.7 1.4 0.15 12.3 1.5 1.7 1 1 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Cluap1 PF10234.9 ETO07337.1 - 0.082 12.3 0.3 0.14 11.6 0.3 1.3 1 0 0 1 1 1 0 Clusterin-associated protein-1 Serpin PF00079.20 ETO07339.1 - 2.2e-31 109.5 0.0 2.9e-31 109.1 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) RAB3GAP2_C PF14656.6 ETO07339.1 - 0.09 11.0 0.4 0.12 10.6 0.4 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus DUF4042 PF13251.6 ETO07339.1 - 0.17 11.6 0.3 0.28 10.8 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4042) WD40 PF00400.32 ETO07341.1 - 1.7e-18 66.6 4.8 3.3e-06 27.7 0.3 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07341.1 - 0.00016 21.9 0.1 0.48 10.8 0.0 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07341.1 - 0.0034 16.1 0.5 1.3 7.6 0.0 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO07341.1 - 0.12 11.1 1.9 3.7 6.2 0.1 2.7 1 1 0 1 1 1 0 Nup133 N terminal like LAP1C PF05609.12 ETO07342.1 - 0.001 18.3 1.8 0.001 18.3 1.8 1.7 2 0 0 2 2 2 1 Lamina-associated polypeptide 1C (LAP1C) DUF4349 PF14257.6 ETO07342.1 - 0.0059 16.1 0.9 0.25 10.8 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF4349) FAM76 PF16046.5 ETO07342.1 - 0.3 10.4 18.8 0.0095 15.3 10.8 2.2 2 0 0 2 2 2 0 FAM76 protein PUFD PF16553.5 ETO07342.1 - 1.5 9.0 6.8 2.2 8.4 0.0 3.3 3 0 0 3 3 3 0 BCORL-PCGF1-binding domain DUF3829 PF12889.7 ETO07343.1 - 0.11 12.0 3.3 0.15 11.5 3.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) DnaB PF00772.21 ETO07346.1 - 0.0036 17.4 0.5 0.016 15.3 0.2 2.1 2 0 0 2 2 2 1 DnaB-like helicase N terminal domain RNA_binding PF01877.17 ETO07346.1 - 0.025 14.9 3.1 2 8.7 0.2 2.9 1 1 1 2 2 2 0 RNA binding DUF1421 PF07223.11 ETO07346.1 - 0.029 14.2 1.4 0.042 13.7 0.0 1.9 2 0 0 2 2 2 0 UBA-like domain (DUF1421) STAR_dimer PF16544.5 ETO07346.1 - 0.079 12.5 4.0 0.27 10.8 0.2 3.0 3 0 0 3 3 3 0 Homodimerisation region of STAR domain protein Imm30 PF15565.6 ETO07346.1 - 0.092 12.8 7.1 5.2 7.2 0.4 3.6 1 1 3 4 4 4 0 Immunity protein 30 NACHT PF05729.12 ETO07347.1 - 8.7e-09 35.5 0.0 1e-08 35.3 0.0 1.0 1 0 0 1 1 1 1 NACHT domain STI1 PF17830.1 ETO07347.1 - 0.074 13.0 0.1 0.23 11.4 0.1 1.8 1 1 0 1 1 1 0 STI1 domain WD40 PF00400.32 ETO07348.1 - 7e-55 181.8 10.9 1.1e-11 45.0 0.2 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07348.1 - 4.2e-21 75.0 2.2 0.00086 19.6 0.0 8.0 2 1 6 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07348.1 - 6.9e-12 45.0 0.0 0.44 9.4 0.0 6.2 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_1 PF01344.25 ETO07348.1 - 2.7e-07 30.1 6.0 6.7e-05 22.4 0.2 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO07348.1 - 6.3e-07 29.3 1.6 0.00029 20.8 0.1 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07348.1 - 6.8e-06 25.8 3.6 0.021 14.8 0.3 4.2 2 1 1 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO07348.1 - 1.7e-05 24.9 10.9 0.2 12.0 0.3 5.9 6 1 1 7 7 7 2 Kelch motif Kelch_5 PF13854.6 ETO07348.1 - 5.6e-05 23.0 3.7 1.9 8.6 0.8 3.7 3 0 0 3 3 3 2 Kelch motif WD40_like PF17005.5 ETO07348.1 - 0.0001 21.8 3.5 0.71 9.1 0.0 4.7 4 1 2 6 6 6 2 WD40-like domain Kelch_3 PF13415.6 ETO07348.1 - 0.00083 19.6 0.3 0.049 13.9 0.0 3.6 4 0 0 4 4 3 1 Galactose oxidase, central domain Nucleoporin_N PF08801.11 ETO07348.1 - 0.0025 16.6 4.5 0.016 14.0 0.2 3.6 1 1 1 2 2 2 1 Nup133 N terminal like DUF727 PF05303.12 ETO07348.1 - 0.0058 16.7 0.1 1.8 8.7 0.0 3.8 2 1 1 3 3 3 1 Protein of unknown function (DUF727) SBD PF17882.1 ETO07348.1 - 0.024 14.5 0.6 2 8.3 0.1 3.7 2 2 1 3 3 3 0 OAA-family lectin sugar binding domain PD40 PF07676.12 ETO07348.1 - 0.024 14.6 8.2 8.7 6.4 0.0 6.3 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO07348.1 - 0.032 13.8 0.0 0.088 12.4 0.0 1.7 1 0 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region DUF5570 PF17731.1 ETO07348.1 - 0.042 13.9 0.1 11 6.1 0.0 3.7 2 1 2 4 4 3 0 Family of unknown function (DUF5570) CD45 PF12567.8 ETO07349.1 - 8.6 6.4 13.7 5.3 7.1 0.4 3.6 4 0 0 4 4 4 0 Leukocyte receptor CD45 Vfa1 PF08432.10 ETO07350.1 - 1 9.7 8.1 2.3 8.5 8.1 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PsbT PF01405.17 ETO07350.1 - 1.4 8.8 11.0 0.61 9.9 0.9 3.2 2 0 0 2 2 2 0 Photosystem II reaction centre T protein Sigma70_ner PF04546.13 ETO07350.1 - 2.4 8.0 7.2 5.2 6.9 7.2 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region FAM176 PF14851.6 ETO07350.1 - 2.9 7.6 5.2 3.7 7.2 1.4 3.0 3 0 0 3 3 3 0 FAM176 family Bd3614-deam PF14439.6 ETO07350.1 - 5.1 7.2 15.0 10 6.2 6.7 2.5 2 0 0 2 2 2 0 Bd3614-like deaminase YlmH_RBD PF17774.1 ETO07351.1 - 0.12 12.6 0.8 1.9 8.8 0.1 3.1 4 0 0 4 4 4 0 Putative RNA-binding domain in YlmH DUF4923 PF16270.5 ETO07352.1 - 0.043 13.6 1.0 0.095 12.5 1.0 1.5 1 1 0 1 1 1 0 Lipocalin-like domain (DUF4923) DUF2457 PF10446.9 ETO07353.1 - 1.3 8.1 10.3 2.5 7.1 10.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TPR_12 PF13424.6 ETO07354.1 - 2.5e-76 252.0 21.9 3.4e-14 52.9 0.0 6.8 3 1 3 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07354.1 - 1e-61 203.3 2.6 3.6e-07 29.9 0.1 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07354.1 - 1.7e-53 176.4 83.4 5e-08 32.4 3.8 11.2 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07354.1 - 5.2e-50 163.5 78.1 4.4e-07 29.6 3.0 10.6 11 0 0 11 11 10 10 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07354.1 - 7.9e-46 150.5 60.9 7.2e-06 25.7 0.3 10.8 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07354.1 - 1.5e-41 137.4 23.3 0.00025 20.8 0.0 10.5 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO07354.1 - 2.6e-16 59.9 0.0 5.2e-09 35.9 0.0 3.5 1 1 2 4 4 4 3 MalT-like TPR region TPR_16 PF13432.6 ETO07354.1 - 7.5e-16 58.5 0.0 0.64 10.7 0.0 8.1 7 3 0 7 7 7 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO07354.1 - 3.2e-14 52.2 24.6 0.0037 17.5 0.2 10.0 9 1 0 9 9 9 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO07354.1 - 3.1e-13 49.4 25.0 0.11 13.2 1.6 10.5 10 0 0 10 10 10 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07354.1 - 1e-11 44.3 54.7 0.034 13.8 0.3 10.6 9 1 0 9 9 9 6 TPR repeat TPR_14 PF13428.6 ETO07354.1 - 9.8e-11 41.5 0.0 2.5 9.1 0.0 8.0 9 1 1 10 10 8 1 Tetratricopeptide repeat SNAP PF14938.6 ETO07354.1 - 1.2e-08 34.8 22.4 0.0073 15.8 0.7 4.1 2 2 2 4 4 4 4 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO07354.1 - 8.7e-06 25.6 52.3 0.0025 17.6 0.3 9.4 6 2 5 11 11 10 4 Domain of unknown function (DUF5113) DUF3856 PF12968.7 ETO07354.1 - 5.2e-05 23.3 8.6 1.5 8.9 0.1 5.5 2 1 3 5 5 5 1 Domain of Unknown Function (DUF3856) TPR_19 PF14559.6 ETO07354.1 - 9.9e-05 22.8 10.4 2 9.0 0.2 5.7 4 4 4 8 8 8 2 Tetratricopeptide repeat MIT PF04212.18 ETO07354.1 - 0.00019 21.4 32.2 1.2 9.3 0.9 8.5 8 1 1 9 9 9 3 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO07354.1 - 0.01 15.5 28.2 8.7 6.0 0.1 7.0 2 1 5 7 7 7 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 ETO07354.1 - 0.017 15.4 37.7 0.77 10.0 0.9 6.9 2 2 6 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO07354.1 - 0.14 12.7 15.2 21 5.7 0.0 6.5 6 2 0 7 7 7 0 Domain of unknown function (DUF4810) DUF2225 PF09986.9 ETO07354.1 - 0.14 11.8 34.3 0.68 9.6 0.5 4.9 1 1 1 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 ETO07354.1 - 0.23 11.5 45.4 0.68 10.0 0.5 8.5 9 0 0 9 9 9 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO07354.1 - 3.1 8.6 41.4 5 8.0 0.3 11.1 11 2 1 12 12 12 0 Sel1 repeat Styelin PF17562.2 ETO07354.1 - 6 7.3 6.6 3.6 8.0 0.2 3.9 3 0 0 3 3 3 0 Styelin Peptidase_C14 PF00656.22 ETO07355.1 - 0.00098 19.1 0.1 0.0019 18.2 0.1 1.4 1 0 0 1 1 1 1 Caspase domain PIN7 PF18475.1 ETO07355.1 - 0.0078 16.8 0.6 0.025 15.2 0.1 2.0 2 0 0 2 2 2 1 PIN domain GW PF13457.6 ETO07355.1 - 0.02 15.5 0.2 0.055 14.1 0.2 1.7 1 0 0 1 1 1 0 GW (Gly-Tryp) dipeptide domain TbpB_A PF17484.2 ETO07355.1 - 0.46 11.2 0.1 0.46 11.2 0.1 2.6 2 2 0 2 2 2 0 N-Lobe handle Tf-binding protein B TPR_12 PF13424.6 ETO07356.1 - 4.1e-41 139.1 3.9 4.4e-19 68.6 0.1 3.6 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07356.1 - 1.1e-33 114.2 0.0 5.5e-08 32.4 0.0 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07356.1 - 2.1e-24 84.3 29.1 2.1e-10 40.0 0.7 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07356.1 - 5.5e-24 82.3 28.5 2.4e-09 36.6 1.1 4.6 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07356.1 - 1.4e-22 78.0 1.8 1.1e-08 34.5 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07356.1 - 1.1e-21 75.2 21.6 7e-08 32.0 0.2 4.7 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO07356.1 - 7.4e-12 44.8 11.3 0.0025 18.1 0.0 5.0 4 2 0 4 4 4 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO07356.1 - 3.3e-10 40.4 0.0 0.015 15.9 0.0 4.6 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO07356.1 - 8.6e-10 38.6 2.9 0.014 16.0 0.1 4.6 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO07356.1 - 7.8e-09 35.6 0.0 0.42 11.5 0.0 4.4 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO07356.1 - 2.3e-08 33.8 20.7 0.028 14.4 0.3 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO07356.1 - 3.5e-06 27.1 11.9 0.0031 17.7 3.5 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ETO07356.1 - 2.2e-05 24.5 11.8 0.81 9.8 0.3 4.3 4 0 0 4 4 4 3 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETO07356.1 - 4e-05 24.0 1.0 0.19 12.3 0.1 3.6 1 1 3 4 4 4 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO07356.1 - 6e-05 22.9 13.8 0.085 12.7 0.3 4.0 2 1 2 4 4 4 1 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETO07356.1 - 0.0001 22.0 4.6 0.003 17.3 1.2 2.4 1 1 1 2 2 2 1 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ETO07356.1 - 0.00015 21.2 0.0 0.0014 18.1 0.0 1.9 1 1 1 2 2 2 1 MalT-like TPR region MIT PF04212.18 ETO07356.1 - 0.00037 20.5 10.3 0.057 13.5 0.4 4.5 5 0 0 5 5 5 1 MIT (microtubule interacting and transport) domain DUF627 PF04781.12 ETO07356.1 - 0.00042 20.3 4.9 0.18 11.8 0.1 3.4 3 1 1 4 4 4 1 Protein of unknown function (DUF627) TPR_9 PF13371.6 ETO07356.1 - 0.0086 16.2 0.0 0.088 13.0 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Mob_Pre PF01076.19 ETO07356.1 - 0.015 15.1 0.2 0.39 10.5 0.2 2.3 2 1 1 3 3 3 0 Plasmid recombination enzyme Pep3_Vps18 PF05131.14 ETO07356.1 - 0.017 14.9 3.2 13 5.6 0.0 3.9 4 0 0 4 4 4 0 Pep3/Vps18/deep orange family TPR_11 PF13414.6 ETO07356.1 - 0.019 14.6 28.9 0.046 13.4 1.1 7.1 5 1 2 7 7 7 0 TPR repeat SHNi-TPR PF10516.9 ETO07356.1 - 0.02 14.3 0.4 9 5.9 0.0 3.6 3 0 0 3 3 3 0 SHNi-TPR PPR PF01535.20 ETO07356.1 - 0.031 14.5 11.6 0.12 12.7 0.1 4.6 5 0 0 5 5 5 0 PPR repeat AHSP PF09236.10 ETO07356.1 - 0.032 14.6 4.4 13 6.3 0.1 3.7 3 1 1 4 4 4 0 Alpha-haemoglobin stabilising protein Vta1_C PF18097.1 ETO07356.1 - 0.034 13.9 0.3 10 5.9 0.0 3.6 4 0 0 4 4 4 0 Vta1 C-terminal domain SPO22 PF08631.10 ETO07356.1 - 0.076 12.5 6.6 1 8.8 0.4 3.2 2 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like DUF739 PF05339.11 ETO07356.1 - 0.16 12.1 3.1 12 6.1 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF739) tRNA-synt_2b PF00587.25 ETO07356.1 - 0.17 11.8 0.5 8.5 6.3 0.2 2.1 2 0 0 2 2 2 0 tRNA synthetase class II core domain (G, H, P, S and T) DUF5475 PF17569.2 ETO07356.1 - 0.21 11.9 1.3 27 5.2 0.0 3.2 2 1 1 3 3 3 0 Family of unknown function (DUF5475) HTH_Bact PF18768.1 ETO07356.1 - 0.25 10.9 8.0 23 4.7 0.0 4.2 4 1 1 5 5 5 0 Helix-turn-helix bacterial domain Tfb2_C PF18307.1 ETO07356.1 - 0.31 11.5 4.9 39 4.8 0.0 3.8 4 0 0 4 4 4 0 Transcription factor Tfb2 (p52) C-terminal domain ATP-synt_E_2 PF08112.11 ETO07356.1 - 0.79 10.0 7.4 3.1 8.1 0.3 3.3 3 0 0 3 3 3 0 ATP synthase epsilon subunit Sel1 PF08238.12 ETO07356.1 - 2.2 9.1 12.7 13 6.7 0.2 4.7 4 1 0 4 4 4 0 Sel1 repeat WD40 PF00400.32 ETO07357.1 - 2.8e-22 78.6 22.9 7.2e-05 23.5 1.1 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07357.1 - 1.2e-09 38.4 0.3 0.2 12.0 0.0 4.3 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07357.1 - 1.7e-06 27.0 2.9 0.022 13.4 0.1 3.7 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07357.1 - 0.00032 20.1 7.5 0.025 13.9 0.7 3.4 2 2 2 4 4 4 2 WD40-like domain RT_RNaseH PF17917.1 ETO07358.1 - 3.6e-20 72.2 1.5 8.3e-20 71.0 1.5 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ETO07358.1 - 1.2e-15 57.6 0.4 4.1e-13 49.4 0.1 2.5 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH_2 PF17919.1 ETO07358.1 - 1.8e-08 34.3 0.4 4.4e-08 33.1 0.4 1.7 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase HEPN PF05168.14 ETO07358.1 - 0.005 17.0 0.1 0.016 15.3 0.1 1.8 1 0 0 1 1 1 1 HEPN domain RVT_1 PF00078.27 ETO07359.1 - 0.028 13.9 0.0 0.048 13.2 0.0 1.3 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) TraE PF05309.11 ETO07359.1 - 0.035 13.5 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 TraE protein SBF2 PF12335.8 ETO07360.1 - 0.00063 19.4 0.4 0.0011 18.6 0.4 1.4 1 0 0 1 1 1 1 Myotubularin protein Late_protein_L1 PF00500.18 ETO07360.1 - 0.02 13.7 0.8 0.9 8.3 0.3 2.1 2 0 0 2 2 2 0 L1 (late) protein DAPDH_C PF16654.5 ETO07360.1 - 0.16 11.8 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Diaminopimelic acid dehydrogenase C-terminal domain Reo_P9 PF06043.11 ETO07361.1 - 0.0029 17.1 1.3 0.0034 16.9 1.3 1.1 1 0 0 1 1 1 1 Reovirus P9-like family Tmemb_161AB PF10268.9 ETO07361.1 - 0.01 14.5 0.5 0.013 14.2 0.5 1.1 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB CBP_BcsR PF10945.8 ETO07361.1 - 0.082 12.4 0.0 0.23 11.0 0.0 1.7 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsR PDEase_I PF00233.19 ETO07362.1 - 3.1e-39 135.1 8.0 8.3e-26 91.2 1.5 2.9 1 1 1 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 ETO07362.1 - 9.8e-16 58.6 0.2 1.2e-06 29.2 0.1 3.8 3 1 0 3 3 3 3 GAF domain GAF_2 PF13185.6 ETO07362.1 - 4.3e-14 53.0 0.2 1.3e-07 32.0 0.0 4.6 4 1 0 4 4 4 3 GAF domain GAF_3 PF13492.6 ETO07362.1 - 6.1e-05 23.4 0.2 0.0015 18.9 0.0 3.4 4 0 0 4 4 4 1 GAF domain OATP PF03137.20 ETO07362.1 - 0.052 11.8 0.0 0.16 10.2 0.0 1.8 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF1722 PF08349.11 ETO07362.1 - 0.09 13.1 0.4 0.71 10.2 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) H_kinase_N PF12282.8 ETO07362.1 - 4.6 7.2 8.3 17 5.3 0.0 3.9 5 0 0 5 5 5 0 Signal transduction histidine kinase TnpB_IS66 PF05717.13 ETO07363.1 - 0.085 12.8 0.0 0.16 11.9 0.0 1.4 1 0 0 1 1 1 0 IS66 Orf2 like protein KMP11 PF03037.16 ETO07366.1 - 0.06 14.1 0.0 0.11 13.3 0.0 1.4 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 PRP38_assoc PF12871.7 ETO07367.1 - 0.69 10.6 70.0 0.048 14.3 9.7 3.3 2 1 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term zf-RING_2 PF13639.6 ETO07368.1 - 0.006 16.9 0.3 0.018 15.4 0.3 1.8 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO07368.1 - 0.022 14.5 0.1 0.022 14.5 0.1 1.9 2 0 0 2 2 2 0 RING-like zinc finger Cwf_Cwc_15 PF04889.12 ETO07368.1 - 0.26 11.0 38.6 0.033 13.9 27.6 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein PI3_PI4_kinase PF00454.27 ETO07372.1 - 4.5e-11 43.0 0.1 4.6e-08 33.2 0.0 2.4 2 0 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase FAM176 PF14851.6 ETO07373.1 - 1.2 8.7 4.3 1.4 8.6 4.3 1.1 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 ETO07373.1 - 4 7.1 10.7 4.2 7.1 10.7 1.1 1 0 0 1 1 1 0 Connexin DUF1980 PF09323.10 ETO07373.1 - 4 7.3 6.9 4 7.3 6.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) NPR3 PF03666.13 ETO07373.1 - 5.1 5.8 14.1 5.2 5.7 14.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 V_ATPase_I PF01496.19 ETO07373.1 - 8.2 4.2 11.2 8.5 4.2 11.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MBT PF02820.18 ETO07374.1 - 0.0043 17.4 0.0 0.01 16.1 0.0 1.6 1 0 0 1 1 1 1 mbt repeat SLC12 PF03522.15 ETO07374.1 - 0.016 14.3 6.6 0.022 13.8 6.6 1.4 1 0 0 1 1 1 0 Solute carrier family 12 MRC1 PF09444.10 ETO07374.1 - 0.23 12.0 13.0 0.38 11.2 13.0 1.3 1 0 0 1 1 1 0 MRC1-like domain YlaH PF14036.6 ETO07374.1 - 2 8.8 7.4 19 5.7 0.0 3.0 3 0 0 3 3 3 0 YlaH-like protein CDC45 PF02724.14 ETO07374.1 - 3.1 6.0 13.9 4.8 5.4 13.9 1.4 1 0 0 1 1 1 0 CDC45-like protein Holin_BhlA PF10960.8 ETO07375.1 - 0.088 12.8 0.2 0.088 12.8 0.2 2.0 2 0 0 2 2 2 0 BhlA holin family Ferlin_C PF16165.5 ETO07375.1 - 0.18 11.7 6.6 0.066 13.2 3.8 1.8 1 1 1 2 2 2 0 Ferlin C-terminus Ion_trans PF00520.31 ETO07378.1 - 1.4e-58 198.0 18.5 6.3e-53 179.5 16.3 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 ETO07378.1 - 3.6e-10 39.1 21.6 2.7e-05 23.1 2.7 3.9 3 1 1 4 4 4 3 Polycystin cation channel Ion_trans PF00520.31 ETO07379.1 - 4.5e-40 137.4 1.3 6.1e-40 137.0 1.3 1.1 1 0 0 1 1 1 1 Ion transport protein Ank_4 PF13637.6 ETO07380.1 - 6.8e-05 23.3 0.1 0.32 11.7 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) DUF2170 PF09938.9 ETO07380.1 - 0.0035 17.0 0.0 0.012 15.3 0.0 1.9 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2170) DUF4347 PF14252.6 ETO07380.1 - 0.059 13.2 0.0 0.16 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) Frataxin_Cyay PF01491.16 ETO07382.1 - 0.26 11.4 2.2 0.74 9.9 0.1 2.1 2 0 0 2 2 2 0 Frataxin-like domain NPR3 PF03666.13 ETO07383.1 - 0.058 12.2 7.1 0.069 11.9 7.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sugar_tr PF00083.24 ETO07383.1 - 2.1 7.1 6.6 1.4 7.7 5.4 1.3 1 1 0 1 1 1 0 Sugar (and other) transporter TAF1D PF15333.6 ETO07383.1 - 3.3 7.4 19.8 4.3 7.0 19.8 1.1 1 0 0 1 1 1 0 TATA box-binding protein-associated factor 1D Virul_fac_BrkB PF03631.15 ETO07384.1 - 0.0057 16.3 8.1 0.018 14.7 1.0 2.1 2 0 0 2 2 2 2 Virulence factor BrkB E1-E2_ATPase PF00122.20 ETO07384.1 - 0.11 12.0 1.5 0.19 11.2 0.1 2.0 2 1 0 2 2 2 0 E1-E2 ATPase DUF1129 PF06570.11 ETO07384.1 - 5.2 6.5 9.8 0.19 11.2 1.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1129) TRAP_alpha PF03896.16 ETO07386.1 - 0.0067 15.7 3.6 0.013 14.7 3.6 1.4 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit DUF913 PF06025.12 ETO07386.1 - 0.0081 15.2 2.5 0.0081 15.2 2.5 2.1 3 0 0 3 3 3 1 Domain of Unknown Function (DUF913) ATP11 PF06644.11 ETO07386.1 - 0.0091 15.8 3.2 0.0091 15.8 3.2 1.9 2 0 0 2 2 2 1 ATP11 protein Tuberin PF03542.16 ETO07386.1 - 0.018 14.2 0.5 0.28 10.2 0.0 2.1 2 0 0 2 2 2 0 Tuberin CDC45 PF02724.14 ETO07386.1 - 0.071 11.4 4.2 0.099 10.9 4.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO07386.1 - 0.21 10.3 2.8 0.3 9.8 2.8 1.3 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO07386.1 - 1.3 7.7 10.0 0.082 11.7 4.7 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 ETO07386.1 - 1.4 9.0 7.1 0.47 10.6 3.4 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Sec62 PF03839.16 ETO07386.1 - 3.6 7.1 6.5 0.32 10.5 1.7 1.8 2 0 0 2 2 2 0 Translocation protein Sec62 DUF4611 PF15387.6 ETO07386.1 - 3.8 7.8 14.7 0.15 12.3 7.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) ORC_WH_C PF18137.1 ETO07386.1 - 4.3 7.4 9.1 0.9 9.6 5.1 1.9 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal NAD_binding_6 PF08030.12 ETO07387.1 - 8.1e-10 39.0 0.0 7.6e-08 32.6 0.0 2.5 1 1 0 1 1 1 1 Ferric reductase NAD binding domain FAD_binding_8 PF08022.12 ETO07387.1 - 1.6e-05 24.9 0.0 3.5e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 FAD-binding domain DUF4870 PF09685.10 ETO07387.1 - 0.061 13.4 2.0 0.11 12.6 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4870) Focal_AT PF03623.13 ETO07388.1 - 0.0022 18.0 12.1 0.052 13.5 0.4 3.5 1 1 2 3 3 3 2 Focal adhesion targeting region Apolipoprotein PF01442.18 ETO07388.1 - 0.007 16.3 3.9 0.28 11.1 3.9 2.9 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 ETO07388.1 - 0.0087 16.1 10.3 0.24 11.5 0.8 3.8 1 1 2 3 3 3 2 Baculovirus polyhedron envelope protein, PEP, C terminus MitMem_reg PF13012.6 ETO07388.1 - 0.016 15.6 2.2 0.051 14.0 1.9 2.2 1 1 1 2 2 1 0 Maintenance of mitochondrial structure and function ApoLp-III PF07464.11 ETO07388.1 - 0.024 14.8 15.7 0.65 10.1 3.4 3.5 1 1 2 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF668 PF05003.12 ETO07388.1 - 0.025 15.1 0.7 2.5 8.6 0.5 3.0 1 1 2 3 3 2 0 Protein of unknown function (DUF668) Peptidase_C98 PF15499.6 ETO07388.1 - 0.027 14.0 8.4 0.033 13.7 1.8 2.7 2 1 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase CLZ PF16526.5 ETO07388.1 - 0.052 13.9 4.8 0.43 11.0 0.5 3.4 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YtxH PF12732.7 ETO07388.1 - 0.059 13.9 5.8 2.1 9.0 3.6 3.6 2 1 0 2 2 2 0 YtxH-like protein HisKA_3 PF07730.13 ETO07388.1 - 0.078 13.5 0.3 2.5 8.7 0.0 3.0 3 0 0 3 3 2 0 Histidine kinase T3SS_basalb_I PF17001.5 ETO07388.1 - 0.078 13.6 3.3 0.46 11.1 0.5 3.4 1 1 3 4 4 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI ApoO PF09769.9 ETO07388.1 - 0.1 12.6 1.7 26 4.8 0.0 3.3 2 1 0 2 2 2 0 Apolipoprotein O HsbA PF12296.8 ETO07388.1 - 0.11 13.0 0.5 0.11 13.0 0.5 3.0 4 0 0 4 4 2 0 Hydrophobic surface binding protein A HSBP1 PF06825.12 ETO07388.1 - 0.11 12.4 10.9 0.072 13.0 0.8 4.0 3 1 0 3 3 3 0 Heat shock factor binding protein 1 Fib_alpha PF08702.10 ETO07388.1 - 0.13 12.4 22.9 0.73 10.0 4.8 3.5 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family DUF2935 PF11155.8 ETO07388.1 - 0.14 12.5 5.5 0.061 13.7 1.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF5601 PF18151.1 ETO07388.1 - 0.16 12.3 3.9 0.15 12.4 0.4 2.9 3 1 0 3 3 1 0 Domain of unknown function (DUF5601) FlaC_arch PF05377.11 ETO07388.1 - 0.18 12.2 15.3 3.6 8.1 1.3 4.9 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 ETO07388.1 - 0.19 12.0 10.9 1.5 9.1 0.7 4.1 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Rx_N PF18052.1 ETO07388.1 - 0.2 12.0 5.4 0.37 11.1 0.0 3.1 3 0 0 3 3 3 0 Rx N-terminal domain Uso1_p115_C PF04871.13 ETO07388.1 - 0.28 11.6 7.7 0.58 10.5 1.1 2.5 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region WXG100 PF06013.12 ETO07388.1 - 0.34 11.2 4.0 16 5.8 0.2 3.7 3 1 1 4 4 3 0 Proteins of 100 residues with WXG NPV_P10 PF05531.12 ETO07388.1 - 0.43 11.1 13.0 2.8 8.5 3.8 3.9 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein FlxA PF14282.6 ETO07388.1 - 0.71 9.9 14.0 0.26 11.3 0.9 3.4 2 1 0 2 2 2 0 FlxA-like protein COG5 PF10392.9 ETO07388.1 - 1 9.5 12.2 1.4 9.1 0.8 3.5 1 1 2 3 3 3 0 Golgi transport complex subunit 5 DUF3810 PF12725.7 ETO07388.1 - 1.1 8.5 7.0 6.6 6.0 3.6 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3810) DUF1640 PF07798.11 ETO07388.1 - 1.2 9.2 23.6 0.5 10.4 9.6 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1640) Annexin PF00191.20 ETO07388.1 - 1.5 8.9 5.7 3.4 7.8 0.5 3.7 3 0 0 3 3 3 0 Annexin ZnuA PF01297.17 ETO07388.1 - 1.5 8.1 5.4 6 6.2 2.5 2.7 2 1 0 2 2 2 0 Zinc-uptake complex component A periplasmic SpmSyn_N PF17950.1 ETO07388.1 - 1.7 8.9 8.7 10 6.4 0.1 3.8 2 1 2 4 4 4 0 S-adenosylmethionine decarboxylase N -terminal SesA PF17107.5 ETO07388.1 - 1.8 8.8 8.1 2.5 8.3 2.6 3.3 1 1 2 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ZYG-11_interact PF05884.12 ETO07388.1 - 1.9 7.8 4.7 33 3.8 4.7 2.1 1 1 0 1 1 1 0 Interactor of ZYG-11 BST2 PF16716.5 ETO07388.1 - 2.1 9.0 10.1 5.5 7.7 0.7 3.6 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 mCpol PF18182.1 ETO07388.1 - 2.7 8.4 6.6 7.2 7.0 0.5 3.4 2 1 0 3 3 3 0 minimal CRISPR polymerase domain Syntaxin_2 PF14523.6 ETO07388.1 - 3.1 8.2 23.0 6 7.3 8.5 4.1 1 1 3 4 4 4 0 Syntaxin-like protein Allexi_40kDa PF05549.11 ETO07388.1 - 3.6 7.0 11.6 2.5 7.5 0.7 2.9 1 1 2 3 3 3 0 Allexivirus 40kDa protein PIN_8 PF18476.1 ETO07388.1 - 4.1 7.2 17.1 8.7 6.1 3.1 3.2 1 1 3 4 4 4 0 PIN like domain RE_MjaI PF09568.10 ETO07388.1 - 4.6 7.0 18.6 1.4 8.7 3.0 4.1 2 2 2 4 4 4 0 MjaI restriction endonuclease eIF3_N PF09440.10 ETO07388.1 - 9.1 6.7 10.3 2 8.8 1.4 3.4 1 1 2 3 3 3 0 eIF3 subunit 6 N terminal domain CdvA PF18822.1 ETO07388.1 - 9.3 6.1 21.9 6.1 6.7 4.8 4.7 4 1 0 4 4 4 0 CdvA-like coiled-coil domain Kinesin PF00225.23 ETO07389.1 - 1.1e-29 103.4 0.0 1.7e-29 102.8 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain DivIC PF04977.15 ETO07389.1 - 0.012 15.4 2.4 0.021 14.6 2.4 1.4 1 0 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.15 ETO07389.1 - 0.021 14.9 7.9 0.064 13.4 7.9 1.8 1 1 0 1 1 1 0 Basic region leucine zipper EBV-NA3 PF05009.12 ETO07389.1 - 0.021 14.4 0.2 0.029 13.9 0.2 1.2 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) Mito_fiss_reg PF05308.11 ETO07389.1 - 0.04 14.0 6.8 0.031 14.4 5.1 1.5 1 1 0 1 1 1 0 Mitochondrial fission regulator Kelch_4 PF13418.6 ETO07392.1 - 0.0032 17.4 0.4 0.13 12.3 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO07392.1 - 0.016 15.5 2.1 0.84 10.0 0.2 3.2 3 0 0 3 3 3 0 Kelch motif GxGYxYP_C PF14323.6 ETO07392.1 - 0.033 14.1 0.3 0.069 13.0 0.3 1.5 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain WD40 PF00400.32 ETO07393.1 - 1.1e-38 130.5 5.6 3.8e-09 37.0 0.0 6.5 7 0 0 7 7 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07393.1 - 4e-15 55.9 0.6 0.0097 16.2 0.0 6.4 1 1 6 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07393.1 - 1.9e-11 43.5 0.5 0.0018 17.3 0.0 5.6 2 2 4 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO07393.1 - 4.7e-06 26.6 0.4 0.0041 17.0 0.1 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO07393.1 - 7.7e-06 24.7 1.5 0.08 11.5 0.1 2.8 2 1 1 3 3 3 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO07393.1 - 6.6e-05 21.8 2.0 0.007 15.2 0.2 2.5 1 1 1 2 2 2 2 Nup133 N terminal like PD40 PF07676.12 ETO07393.1 - 7.4e-05 22.6 1.2 12 6.0 0.0 4.9 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO07393.1 - 0.0008 18.8 3.3 0.71 9.1 0.0 3.4 1 1 2 3 3 3 2 WD40-like domain Nbas_N PF15492.6 ETO07393.1 - 0.004 16.5 2.6 1 8.7 0.1 4.2 2 2 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal HARP PF07443.13 ETO07393.1 - 0.019 14.6 0.1 1.1 8.9 0.0 3.3 4 0 0 4 4 4 0 HepA-related protein (HARP) Mid2 PF04478.12 ETO07393.1 - 0.073 12.9 0.1 2.3 8.0 0.0 2.6 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Ubiquitin_3 PF14836.6 ETO07393.1 - 0.09 12.8 0.1 8.3 6.5 0.0 2.9 1 1 2 3 3 3 0 Ubiquitin-like domain WD40 PF00400.32 ETO07394.1 - 7.6e-117 377.9 62.3 3.8e-10 40.2 0.3 15.1 15 0 0 15 15 15 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07394.1 - 1.8e-35 121.1 9.7 0.014 15.7 0.0 12.7 1 1 12 13 13 13 12 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07394.1 - 5.3e-19 68.7 13.0 0.00066 19.1 0.0 8.1 4 2 1 8 8 8 5 WD40-like domain NACHT PF05729.12 ETO07394.1 - 1.9e-09 37.7 0.0 4.1e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO07394.1 - 1.1e-05 26.0 0.9 0.00031 21.3 0.0 3.5 3 0 0 3 3 3 1 AAA domain Cytochrom_D1 PF02239.16 ETO07394.1 - 8e-05 21.3 3.1 0.34 9.4 0.2 4.1 4 0 0 4 4 4 2 Cytochrome D1 heme domain AAA_22 PF13401.6 ETO07394.1 - 0.00096 19.4 0.0 0.004 17.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain Sulfotransfer_4 PF17784.1 ETO07394.1 - 0.0017 18.3 0.4 0.0048 16.8 0.4 1.7 1 0 0 1 1 1 1 Sulfotransferase domain PD40 PF07676.12 ETO07394.1 - 0.022 14.7 19.7 16 5.6 0.1 8.7 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat RNA_helicase PF00910.22 ETO07394.1 - 0.03 14.7 0.0 0.22 11.9 0.0 2.7 1 0 0 1 1 1 0 RNA helicase CbiA PF01656.23 ETO07394.1 - 0.092 12.8 2.1 2.5 8.2 0.1 3.1 2 1 1 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_14 PF13173.6 ETO07394.1 - 0.34 10.9 8.8 0.026 14.6 0.9 3.5 3 1 0 3 3 3 0 AAA domain WD40 PF00400.32 ETO07395.1 - 6.2e-56 185.1 18.8 8.4e-11 42.3 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07395.1 - 9.5e-23 80.3 0.5 0.00079 19.7 0.0 5.5 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07395.1 - 5e-14 52.0 0.5 0.006 15.6 0.0 5.8 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO07395.1 - 8.7e-13 48.2 9.8 0.00072 19.0 0.3 4.1 2 1 2 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO07395.1 - 2.5e-09 37.3 0.4 0.0055 16.6 0.0 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO07395.1 - 7.5e-09 34.8 5.1 0.015 14.0 0.0 5.0 1 1 2 4 4 4 3 Nucleoporin Nup120/160 NHL PF01436.21 ETO07395.1 - 2.6e-05 24.0 0.5 0.34 11.1 0.0 2.6 2 0 0 2 2 2 2 NHL repeat Cytochrom_D1 PF02239.16 ETO07395.1 - 0.00034 19.3 0.1 0.0032 16.0 0.0 2.3 2 1 1 3 3 3 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO07395.1 - 0.00055 19.7 0.0 16 5.6 0.0 4.8 5 0 0 5 5 5 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO07395.1 - 0.00059 18.9 0.5 4.1 6.2 0.1 3.6 1 1 2 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO07395.1 - 0.0012 18.3 1.3 1.6 8.0 0.0 3.9 3 1 1 5 5 5 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO07395.1 - 0.0017 18.0 0.0 0.0085 15.7 0.0 2.0 2 0 0 2 2 2 1 PQQ-like domain PD40 PF07676.12 ETO07395.1 - 0.0021 17.9 7.4 4.7 7.3 0.1 5.1 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO07395.1 - 0.0021 17.2 0.1 0.41 9.6 0.0 2.6 3 0 0 3 3 3 1 VID27 C-terminal WD40-like domain DUF5570 PF17731.1 ETO07395.1 - 0.0029 17.7 0.1 6.5 6.9 0.0 3.6 2 1 1 3 3 3 1 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO07395.1 - 0.003 16.7 1.7 0.011 14.9 0.7 2.0 1 1 1 2 2 2 1 Coatomer WD associated region DUF1854 PF08909.11 ETO07395.1 - 0.016 15.0 0.5 0.23 11.3 0.0 2.8 1 1 1 3 3 3 0 Domain of unknown function (DUF1854) SBD PF17882.1 ETO07395.1 - 0.052 13.4 0.6 56 3.6 0.0 3.6 3 1 1 4 4 4 0 OAA-family lectin sugar binding domain Granulin PF00396.18 ETO07397.1 - 0.063 13.6 0.5 0.063 13.6 0.5 2.4 2 0 0 2 2 2 0 Granulin Kelch_6 PF13964.6 ETO07398.1 - 3.6e-08 33.4 1.7 1.1e-06 28.6 0.2 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO07398.1 - 3.9e-05 23.1 0.5 3.9e-05 23.1 0.5 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO07398.1 - 0.00024 21.0 1.8 0.00041 20.3 0.1 2.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO07398.1 - 0.0012 19.0 0.0 0.011 16.0 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07398.1 - 0.61 10.2 5.0 0.45 10.6 1.0 2.7 3 0 0 3 3 3 0 Kelch motif RVT_1 PF00078.27 ETO07399.1 - 1.3e-11 44.4 0.1 7.8e-06 25.6 0.0 2.8 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) DUF4930 PF16284.5 ETO07399.1 - 1 9.3 5.5 4 7.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4930) RTP1_C1 PF10363.9 ETO07401.1 - 0.00037 20.6 18.4 0.017 15.3 0.2 5.8 2 1 3 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF3944 PF13099.6 ETO07401.1 - 0.0016 18.3 2.6 0.3 11.0 0.1 4.7 4 0 0 4 4 4 1 Domain of unknown function (DUF3944) Ank_5 PF13857.6 ETO07401.1 - 0.0017 18.7 0.1 0.021 15.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) HEAT_2 PF13646.6 ETO07401.1 - 0.0036 17.6 0.0 3.7 8.0 0.0 2.9 2 0 0 2 2 2 2 HEAT repeats Ank_3 PF13606.6 ETO07401.1 - 0.0046 17.3 0.1 0.095 13.3 0.0 3.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO07401.1 - 0.021 15.4 0.3 0.16 12.6 0.1 2.7 2 0 0 2 2 1 0 Ankyrin repeats (3 copies) Ferritin-like PF12902.7 ETO07401.1 - 0.024 14.5 0.0 0.053 13.4 0.0 1.5 1 0 0 1 1 1 0 Ferritin-like HEAT PF02985.22 ETO07401.1 - 0.025 14.8 0.0 8.2 7.0 0.0 4.0 4 0 0 4 4 3 0 HEAT repeat Ank_4 PF13637.6 ETO07401.1 - 0.041 14.5 0.2 0.21 12.2 0.2 2.4 1 0 0 1 1 1 0 Ankyrin repeats (many copies) HEAT_EZ PF13513.6 ETO07401.1 - 0.078 13.5 0.0 28 5.4 0.0 3.1 2 0 0 2 2 2 0 HEAT-like repeat BP28CT PF08146.12 ETO07401.1 - 0.12 12.2 12.2 1.3 8.8 0.7 4.0 3 1 1 4 4 4 0 BP28CT (NUC211) domain DUF4119 PF13494.6 ETO07401.1 - 8.6 6.6 8.3 1.1 9.4 0.2 4.0 4 1 0 4 4 3 0 Domain of unknown function, B. Theta Gene description (DUF4119) WD40 PF00400.32 ETO07402.1 - 8.1e-08 32.8 3.1 0.004 18.0 0.1 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 ETO07403.1 - 6.6e-18 64.8 9.5 5.2e-07 30.3 0.4 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07403.1 - 1.4e-07 30.5 1.0 0.00091 18.0 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07403.1 - 2.1e-07 31.1 0.1 0.0056 17.0 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07403.1 - 0.00035 20.0 1.7 0.029 13.7 0.5 2.1 2 0 0 2 2 2 2 WD40-like domain Herpes_glycop PF01528.16 ETO07405.1 - 0.38 9.6 9.6 0.051 12.4 3.7 1.9 2 0 0 2 2 2 0 Herpesvirus glycoprotein M 2-oxoacid_dh PF00198.23 ETO07406.1 - 5.2e-68 229.0 0.1 3.6e-66 222.9 0.1 2.1 1 1 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Biotin_lipoyl PF00364.22 ETO07406.1 - 1.2e-16 60.2 1.9 1.9e-16 59.6 1.9 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme GCV_H PF01597.19 ETO07406.1 - 0.06 13.2 0.4 0.12 12.3 0.4 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF4164 PF13747.6 ETO07406.1 - 0.093 13.0 0.5 0.19 12.1 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4164) Apt1 PF10351.9 ETO07406.1 - 0.32 9.8 9.1 0.45 9.3 9.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 ETO07406.1 - 0.86 8.3 4.5 1.3 7.7 4.5 1.2 1 0 0 1 1 1 0 Presenilin F-box PF00646.33 ETO07407.1 - 0.00082 19.2 0.0 0.0021 17.9 0.0 1.7 1 0 0 1 1 1 1 F-box domain Takusan PF04822.13 ETO07407.1 - 3.4 7.6 7.5 6.8 6.6 0.4 2.9 2 1 1 3 3 3 0 Takusan Intein_splicing PF14890.6 ETO07409.1 - 0.44 10.5 4.3 0.42 10.5 3.4 1.5 1 1 0 1 1 1 0 Intein splicing domain WD40 PF00400.32 ETO07411.1 - 5.3e-20 71.4 10.3 1.5e-05 25.7 0.4 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07411.1 - 7.2e-11 41.4 0.4 0.0012 17.6 0.6 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07411.1 - 0.00066 19.9 0.1 0.39 11.1 0.1 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Aldo_ket_red PF00248.21 ETO07412.1 - 9.8e-08 31.5 0.1 1.1e-07 31.3 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family FliG_M PF14841.6 ETO07412.1 - 0.029 14.6 0.1 0.052 13.8 0.1 1.4 1 0 0 1 1 1 0 FliG middle domain Ras PF00071.22 ETO07413.1 - 1.4e-25 89.8 0.1 1.6e-25 89.6 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO07413.1 - 1e-14 54.8 0.0 1.4e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO07413.1 - 0.00013 21.5 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family SRPRB PF09439.10 ETO07413.1 - 0.038 13.4 0.0 0.061 12.8 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit RPM2 PF08579.11 ETO07414.1 - 0.046 14.1 3.4 0.066 13.6 3.4 1.3 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) U-box PF04564.15 ETO07416.1 - 1.8e-11 44.0 0.1 2.8e-10 40.2 0.1 2.6 1 1 0 1 1 1 1 U-box domain FliJ PF02050.16 ETO07416.1 - 0.11 12.7 11.0 0.32 11.2 1.0 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein CTP_transf_like PF01467.26 ETO07416.1 - 0.65 10.2 3.0 0.83 9.8 1.4 1.8 1 1 1 2 2 2 0 Cytidylyltransferase-like TPR_1 PF00515.28 ETO07417.1 - 1.7e-16 59.2 12.3 2.8e-05 23.7 0.0 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO07417.1 - 9.5e-16 57.9 8.6 1.1e-05 25.6 1.3 5.7 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07417.1 - 4.9e-12 45.0 8.6 0.0096 15.9 0.0 6.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07417.1 - 9.9e-11 40.9 10.4 0.095 12.9 0.9 6.8 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07417.1 - 3.2e-10 39.4 13.5 0.02 15.1 1.1 6.6 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO07417.1 - 8.7e-05 23.0 0.5 21 6.2 0.0 5.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO07417.1 - 0.00017 22.0 9.8 3.1 8.6 0.5 5.3 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07417.1 - 0.00034 20.4 2.2 1.8 8.6 0.2 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO07417.1 - 0.0055 17.2 10.0 1.6 9.3 0.2 5.7 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO07417.1 - 0.0083 16.8 1.3 0.44 11.2 0.0 3.8 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO07417.1 - 0.074 13.3 11.3 3.7 7.8 1.1 4.1 3 2 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETO07417.1 - 0.2 11.4 6.2 8 6.2 0.0 4.8 5 0 0 5 5 5 0 TPR repeat ANAPC5 PF12862.7 ETO07417.1 - 0.82 9.8 9.2 2.3 8.3 3.3 3.2 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 5 Kelch_4 PF13418.6 ETO07418.1 - 1.6e-43 146.4 11.6 2e-10 40.5 0.1 6.6 6 0 0 6 6 6 6 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO07418.1 - 2e-37 126.5 4.9 4.7e-14 51.7 0.0 6.3 6 1 0 6 6 6 5 Kelch motif Kelch_5 PF13854.6 ETO07418.1 - 1.2e-36 124.1 16.8 4e-09 36.3 0.0 6.9 7 0 0 7 7 7 6 Kelch motif Kelch_6 PF13964.6 ETO07418.1 - 3.6e-34 115.9 6.2 4.5e-08 33.1 0.0 6.6 4 1 2 6 6 6 6 Kelch motif Kelch_3 PF13415.6 ETO07418.1 - 4.7e-34 116.0 16.6 1.7e-12 47.3 0.1 7.6 7 1 0 7 7 7 4 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07418.1 - 8.8e-31 104.7 11.9 5.1e-08 32.6 0.0 6.8 7 0 0 7 7 7 5 Kelch motif RPEL PF02755.15 ETO07418.1 - 7.5e-06 25.5 0.0 0.1 12.3 0.0 2.6 2 0 0 2 2 2 2 RPEL repeat DUF1985 PF09331.11 ETO07419.1 - 0.018 15.0 3.5 0.031 14.3 3.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1985) BRCT_2 PF16589.5 ETO07419.1 - 0.1 13.0 1.9 1.6 9.2 1.5 2.5 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain DOT1 PF08123.13 ETO07420.1 - 3.7e-14 52.7 0.2 7.9e-14 51.7 0.2 1.5 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_4 PF02390.17 ETO07420.1 - 0.017 14.6 0.6 0.028 13.9 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase CM_2 PF01817.21 ETO07420.1 - 0.068 13.5 0.1 0.45 10.9 0.1 2.1 2 0 0 2 2 2 0 Chorismate mutase type II Methyltransf_2 PF00891.18 ETO07420.1 - 0.078 12.3 0.0 0.17 11.2 0.0 1.6 1 1 0 1 1 1 0 O-methyltransferase domain DUF370 PF04025.12 ETO07420.1 - 0.11 12.7 0.0 0.32 11.2 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF370) AATF-Che1 PF13339.6 ETO07420.1 - 1.8 9.3 7.5 39 4.9 1.7 3.2 2 1 0 3 3 3 0 Apoptosis antagonizing transcription factor DUF3342 PF11822.8 ETO07421.1 - 0.096 12.9 0.5 0.34 11.1 0.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Abhydrolase_3 PF07859.13 ETO07422.1 - 2.4e-05 24.3 0.1 3.9e-05 23.6 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO07422.1 - 0.00023 21.8 0.1 0.0004 21.1 0.1 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ribosomal_S19 PF00203.21 ETO07423.1 - 2.9e-31 107.2 1.1 5.3e-31 106.3 1.1 1.4 1 0 0 1 1 1 1 Ribosomal protein S19 Pkinase PF00069.25 ETO07424.1 - 2.9e-09 36.7 0.0 0.00094 18.6 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Trp_Tyr_perm PF03222.13 ETO07425.1 - 1.8e-05 24.0 1.1 1.8e-05 24.0 1.1 1.7 1 1 1 2 2 2 1 Tryptophan/tyrosine permease family DUF3188 PF11384.8 ETO07425.1 - 0.0073 16.0 0.2 0.024 14.4 0.2 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF3188) Neur_chan_memb PF02932.16 ETO07425.1 - 0.074 13.1 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MarC PF01914.17 ETO07426.1 - 0.13 11.7 0.0 0.25 10.7 0.0 1.5 1 0 0 1 1 1 0 MarC family integral membrane protein Aa_trans PF01490.18 ETO07426.1 - 0.88 8.2 5.5 2.6 6.6 5.5 1.8 1 1 0 1 1 1 0 Transmembrane amino acid transporter protein DUF5090 PF17009.5 ETO07426.1 - 0.95 9.4 4.6 0.2 11.6 0.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5090) RRM_1 PF00076.22 ETO07427.1 - 8.5e-21 73.6 8.7 6.7e-08 32.2 0.3 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Viral_Rep PF02407.16 ETO07427.1 - 0.051 13.8 2.8 0.086 13.1 0.2 2.6 3 1 1 4 4 4 0 Putative viral replication protein RRM_3 PF08777.11 ETO07427.1 - 0.15 12.1 2.0 4.3 7.4 0.1 3.2 3 0 0 3 3 3 0 RNA binding motif Nup35_RRM_2 PF14605.6 ETO07427.1 - 0.16 12.0 0.6 52 3.9 0.0 3.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Dapper PF15268.6 ETO07429.1 - 0.00062 18.8 16.0 0.00076 18.5 16.0 1.2 1 0 0 1 1 1 1 Dapper NOA36 PF06524.12 ETO07429.1 - 0.005 16.2 23.2 0.012 14.9 23.2 1.6 1 0 0 1 1 1 1 NOA36 protein Macoilin PF09726.9 ETO07429.1 - 0.014 13.9 26.3 0.019 13.6 26.3 1.2 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 ETO07429.1 - 0.053 12.9 23.5 0.12 11.7 23.5 1.5 1 0 0 1 1 1 0 FAM76 protein SDA1 PF05285.12 ETO07429.1 - 0.51 9.7 33.9 0.91 8.9 33.9 1.3 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 ETO07429.1 - 1.1 8.0 22.3 1.6 7.4 22.3 1.3 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 ETO07429.1 - 2.1 7.7 16.7 4.8 6.5 16.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CAC1F_C PF16885.5 ETO07429.1 - 2.4 7.7 13.5 4.1 7.0 13.5 1.4 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Nop14 PF04147.12 ETO07429.1 - 2.7 6.1 33.1 4.1 5.5 33.1 1.2 1 0 0 1 1 1 0 Nop14-like family Herpes_LMP1 PF05297.11 ETO07429.1 - 3.3 6.8 13.4 4.4 6.4 13.4 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) PPP4R2 PF09184.11 ETO07429.1 - 4.1 6.9 40.2 0.011 15.4 29.9 1.9 3 0 0 3 3 3 0 PPP4R2 Trypan_PARP PF05887.11 ETO07429.1 - 7.3 6.6 12.3 12 5.8 12.3 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PDDEXK_6 PF04720.12 ETO07430.1 - 0.0004 20.4 7.5 0.015 15.3 0.1 2.1 2 0 0 2 2 2 2 PDDEXK-like family of unknown function Synapsin_C PF02750.14 ETO07431.1 - 3e-25 88.9 0.0 4.1e-25 88.5 0.0 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain Synapsin PF02078.16 ETO07432.1 - 2.9e-18 66.0 0.0 4.8e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 Synapsin, N-terminal domain Synapsin_C PF02750.14 ETO07432.1 - 3.8e-17 62.5 0.0 4.9e-17 62.1 0.0 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain CTX_RstB PF07459.11 ETO07434.1 - 0.11 12.7 1.0 1.8 8.9 0.2 2.4 1 1 1 2 2 2 0 CTX phage RstB protein XPG_I PF00867.18 ETO07436.1 - 7.5e-25 87.1 1.1 1.6e-24 86.0 0.0 2.3 2 0 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 ETO07436.1 - 0.00068 19.2 0.0 0.00068 19.2 0.0 2.8 3 0 0 3 3 3 1 XPG domain containing zf-RanBP PF00641.18 ETO07436.1 - 0.54 9.6 31.2 0.49 9.8 0.7 3.4 3 0 0 3 3 3 0 Zn-finger in Ran binding protein and others Cytomega_UL84 PF06284.11 ETO07436.1 - 2 6.8 6.2 3.2 6.1 6.2 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Nop14 PF04147.12 ETO07437.1 - 0.0047 15.2 32.0 0.0053 15.1 32.0 1.0 1 0 0 1 1 1 1 Nop14-like family DUF2457 PF10446.9 ETO07437.1 - 0.0048 16.1 26.2 0.0057 15.9 26.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO07437.1 - 0.055 11.8 22.7 0.066 11.5 22.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 ETO07437.1 - 0.066 12.9 41.1 0.1 12.3 41.1 1.4 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Zip PF02535.22 ETO07437.1 - 0.099 11.8 8.5 0.11 11.6 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BUD22 PF09073.10 ETO07437.1 - 0.11 11.9 24.3 0.13 11.6 24.3 1.2 1 0 0 1 1 1 0 BUD22 CNDH2_C PF16858.5 ETO07437.1 - 0.55 10.1 21.0 0.73 9.6 21.0 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term FAM76 PF16046.5 ETO07437.1 - 0.77 9.1 10.5 1.1 8.6 10.5 1.3 1 0 0 1 1 1 0 FAM76 protein SDA1 PF05285.12 ETO07437.1 - 1.5 8.2 31.0 1.8 7.9 31.0 1.2 1 0 0 1 1 1 0 SDA1 CDC27 PF09507.10 ETO07437.1 - 2.4 7.4 26.3 3.6 6.9 26.3 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 ETO07437.1 - 3.1 6.4 14.1 3.7 6.2 14.1 1.3 1 0 0 1 1 1 0 Presenilin RRN3 PF05327.11 ETO07437.1 - 5 5.5 18.4 6.1 5.3 18.4 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 USP8_dimer PF08969.11 ETO07438.1 - 0.05 13.8 1.2 0.096 12.9 0.0 1.9 2 1 0 2 2 2 0 USP8 dimerisation domain WD40 PF00400.32 ETO07441.1 - 3.4e-07 30.8 7.9 0.042 14.7 0.1 3.8 2 1 1 3 3 3 3 WD domain, G-beta repeat WD40 PF00400.32 ETO07442.1 - 6.6e-106 343.2 55.2 1e-09 38.9 0.5 14.8 14 1 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07442.1 - 4.4e-23 81.4 12.3 0.00076 19.7 0.1 11.8 2 2 11 13 13 13 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07442.1 - 1.2e-20 73.8 6.2 0.27 10.1 0.0 11.3 2 2 8 10 10 10 7 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO07442.1 - 2.9e-10 40.3 0.0 6.2e-10 39.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Str_synth PF03088.16 ETO07442.1 - 2.1e-06 27.8 3.3 2.9 8.1 0.0 8.2 7 2 3 10 10 10 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO07442.1 - 2.3e-06 26.4 5.3 0.79 8.2 0.1 5.3 1 1 4 6 6 6 2 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO07442.1 - 4.3e-05 23.1 0.5 0.00011 21.8 0.5 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO07442.1 - 0.0011 19.1 0.1 0.0047 17.1 0.1 2.1 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO07442.1 - 0.0017 18.7 0.0 0.0058 16.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain Pentapeptide_3 PF13576.6 ETO07442.1 - 0.0017 18.5 0.5 0.0049 17.0 0.5 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Spc29 PF17082.5 ETO07442.1 - 0.016 15.1 1.9 0.18 11.6 0.0 3.6 3 0 0 3 3 3 0 Spindle Pole Component 29 Peptidase_M3_N PF08439.10 ETO07442.1 - 0.037 14.3 0.1 0.13 12.5 0.1 1.9 1 0 0 1 1 1 0 Oligopeptidase F PD40 PF07676.12 ETO07442.1 - 0.041 13.8 19.6 22 5.2 0.1 7.9 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat AAA_18 PF13238.6 ETO07442.1 - 0.096 13.2 0.0 0.41 11.2 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO07442.1 - 0.18 12.2 0.0 1.3 9.4 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain RRM_1 PF00076.22 ETO07443.1 - 2e-17 62.7 3.9 2.3e-17 62.6 0.0 2.6 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO07443.1 - 0.064 13.4 0.0 0.32 11.2 0.0 2.2 1 1 0 1 1 1 0 RNA recognition motif Lin-8 PF03353.15 ETO07443.1 - 0.2 11.2 6.1 0.27 10.8 6.1 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 ETO07443.1 - 2.2 6.9 7.5 2.9 6.6 7.5 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO07443.1 - 7.6 5.0 18.8 8.6 4.8 18.8 1.1 1 0 0 1 1 1 0 Macoilin family TFIIF_alpha PF05793.12 ETO07444.1 - 3.2e-05 22.7 11.4 3.2e-05 22.7 11.4 2.1 2 0 0 2 2 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) YL1 PF05764.13 ETO07444.1 - 0.00038 20.6 18.9 0.00038 20.6 18.9 2.5 2 1 0 2 2 1 1 YL1 nuclear protein CDC45 PF02724.14 ETO07444.1 - 0.0036 15.7 42.9 0.018 13.4 16.2 2.2 2 0 0 2 2 2 2 CDC45-like protein Peptidase_S64 PF08192.11 ETO07444.1 - 0.19 10.2 25.5 0.0099 14.4 10.5 2.1 2 0 0 2 2 2 0 Peptidase family S64 Nop14 PF04147.12 ETO07444.1 - 0.3 9.2 53.3 0.23 9.6 25.4 2.1 2 0 0 2 2 2 0 Nop14-like family Apt1 PF10351.9 ETO07444.1 - 0.31 9.9 19.0 0.56 9.0 3.9 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain RNA_pol_Rpc4 PF05132.14 ETO07444.1 - 0.54 10.7 23.4 0.2 12.1 1.7 2.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 Mpp10 PF04006.12 ETO07444.1 - 0.62 8.4 51.4 1.4 7.3 18.3 2.2 2 0 0 2 2 2 0 Mpp10 protein Tim54 PF11711.8 ETO07444.1 - 0.81 8.4 22.6 1.3 7.7 8.6 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4228 PF14009.6 ETO07444.1 - 0.96 9.8 7.9 2.8 8.3 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) LAP1C PF05609.12 ETO07444.1 - 2 7.4 28.4 1.2 8.2 12.9 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) BUD22 PF09073.10 ETO07444.1 - 4.6 6.5 49.7 0.96 8.7 18.7 2.2 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 ETO07444.1 - 4.8 6.5 57.7 5 6.5 29.0 2.3 2 0 0 2 2 2 0 SDA1 PNISR PF15996.5 ETO07444.1 - 5.9 7.1 39.4 0.81 9.9 13.5 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Ras PF00071.22 ETO07445.1 - 7.8e-50 168.6 1.8 3.7e-24 85.2 0.2 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO07445.1 - 1.2e-25 90.1 0.4 3.1e-20 72.6 0.1 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO07445.1 - 1.4e-11 44.1 0.1 1.8e-05 24.3 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO07445.1 - 0.0055 16.8 0.0 0.01 15.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO07445.1 - 0.049 13.0 0.1 1 8.7 0.0 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region Glyco_tran_28_C PF04101.16 ETO07447.1 - 5.1e-21 75.4 0.0 6.2e-21 75.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase family 28 C-terminal domain PrgU PF09627.10 ETO07448.1 - 0.029 14.3 0.1 3.4 7.7 0.0 2.4 2 1 0 2 2 2 0 PrgU-like protein DUF2192 PF09958.9 ETO07448.1 - 0.065 12.8 0.0 0.14 11.7 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2192) WD40 PF00400.32 ETO07449.1 - 2.7e-27 94.4 2.4 7.2e-07 29.8 0.1 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07449.1 - 6.1e-07 29.7 0.0 0.018 15.3 0.0 2.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07449.1 - 0.00029 19.6 0.7 1.1 7.8 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO07449.1 - 0.008 15.0 0.3 0.97 8.1 0.0 2.4 1 1 1 2 2 2 2 Nup133 N terminal like eIF2A PF08662.11 ETO07449.1 - 0.0087 16.0 0.0 0.62 9.9 0.0 2.7 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO07449.1 - 0.017 14.1 0.0 1.2 8.0 0.0 2.4 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO07449.1 - 0.021 14.1 0.4 1.1 8.5 0.0 2.5 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Ras PF00071.22 ETO07450.1 - 1.8e-11 43.9 0.0 2.7e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO07450.1 - 4e-05 23.8 0.0 6.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 ETO07450.1 - 0.067 13.6 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.23 ETO07450.1 - 0.15 12.2 0.2 0.3 11.2 0.2 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase WD40 PF00400.32 ETO07451.1 - 4.6e-32 109.5 29.5 1.9e-06 28.5 1.3 8.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07451.1 - 9.1e-10 38.7 0.1 0.017 15.4 0.0 5.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07451.1 - 1.4e-08 33.8 6.4 0.021 13.5 0.1 5.1 2 2 3 5 5 5 5 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO07451.1 - 0.036 14.8 1.5 0.036 14.8 1.5 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger HIP1_clath_bdg PF16515.5 ETO07451.1 - 1.4 9.6 10.7 4.2 8.0 10.7 1.8 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 WD40 PF00400.32 ETO07453.1 - 5.4e-68 223.3 15.1 9.7e-13 48.4 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07453.1 - 7.8e-28 96.6 2.7 0.00052 20.3 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07453.1 - 1.4e-15 57.1 1.2 0.0032 16.5 0.0 6.4 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO07453.1 - 1.2e-11 44.9 0.3 1e-05 25.5 0.0 3.3 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO07453.1 - 1.1e-10 41.4 1.1 0.0061 15.9 0.1 4.5 2 2 3 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO07453.1 - 5.6e-10 38.5 2.9 0.038 12.6 0.0 5.4 1 1 2 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO07453.1 - 3.8e-09 35.6 0.5 0.00033 19.3 0.1 3.4 2 2 1 3 3 3 3 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO07453.1 - 1.2e-06 27.9 0.4 0.16 10.9 0.0 3.2 1 1 2 3 3 3 3 Coatomer WD associated region DUF5570 PF17731.1 ETO07453.1 - 1.5e-05 25.1 6.4 2.2 8.4 0.0 5.1 1 1 5 6 6 6 2 Family of unknown function (DUF5570) BBS2_Mid PF14783.6 ETO07453.1 - 0.00035 20.6 3.5 0.41 10.7 0.4 4.7 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 ETO07453.1 - 0.0012 18.7 12.2 6.8 6.7 0.2 5.3 6 0 0 6 6 5 1 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO07453.1 - 0.0014 18.2 0.1 0.021 14.5 0.0 3.0 5 0 0 5 5 4 1 HepA-related protein (HARP) HTH_micro PF17007.5 ETO07453.1 - 0.0021 17.0 1.6 0.47 9.2 0.0 2.8 2 1 1 3 3 3 2 HTH-like PSII_BNR PF14870.6 ETO07453.1 - 0.0033 16.7 0.2 0.0065 15.8 0.1 1.5 1 1 0 1 1 1 1 Photosynthesis system II assembly factor YCF48 DUF5449 PF17528.2 ETO07453.1 - 0.0038 17.0 3.2 2.1 8.1 0.1 3.2 3 1 1 4 4 3 2 Family of unknown function (DUF5449) ROS_MUCR PF05443.11 ETO07453.1 - 0.0089 16.1 0.1 12 6.0 0.0 4.1 3 1 0 3 3 3 0 ROS/MUCR transcriptional regulator protein PLD_C PF12357.8 ETO07453.1 - 0.015 15.2 0.0 38 4.3 0.0 4.4 4 1 0 4 4 4 0 Phospholipase D C terminal Nbas_N PF15492.6 ETO07453.1 - 0.024 14.0 2.1 3 7.1 0.0 3.7 1 1 4 5 5 5 0 Neuroblastoma-amplified sequence, N terminal Vps16_N PF04841.13 ETO07453.1 - 0.04 12.7 0.1 0.45 9.2 0.0 2.2 1 1 1 2 2 2 0 Vps16, N-terminal region WD40 PF00400.32 ETO07454.1 - 1.3e-60 199.9 20.5 1.7e-09 38.2 0.4 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07454.1 - 1.2e-19 70.4 2.6 0.00043 20.5 0.1 6.9 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07454.1 - 3.1e-15 55.9 0.1 0.026 13.5 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO07454.1 - 1.8e-11 44.3 1.2 2.4e-05 24.3 0.1 3.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO07454.1 - 1.8e-07 30.2 7.2 0.056 12.1 0.1 4.5 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07454.1 - 2.6e-07 30.3 0.7 0.012 15.0 0.1 3.1 2 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO07454.1 - 0.00026 19.6 0.7 0.75 8.3 0.0 2.8 1 1 3 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO07454.1 - 0.059 13.3 7.0 26 4.9 0.0 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO07454.1 - 0.068 13.3 0.2 11 6.3 0.0 3.7 3 1 0 4 4 4 0 Strictosidine synthase PALB2_WD40 PF16756.5 ETO07454.1 - 0.17 10.8 3.0 17 4.2 0.0 4.0 1 1 4 5 5 5 0 Partner and localizer of BRCA2 WD40 domain WD40 PF00400.32 ETO07455.1 - 4.4e-16 59.0 5.4 1.2e-06 29.1 1.4 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07455.1 - 0.0063 16.8 0.2 13 6.1 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain vATP-synt_AC39 PF01992.16 ETO07456.1 - 3.6e-43 148.3 3.6 4.4e-43 148.1 3.6 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit Peptidase_M15_3 PF08291.11 ETO07457.1 - 4.6e-15 55.7 0.0 1.1e-14 54.5 0.0 1.6 1 0 0 1 1 1 1 Peptidase M15 Plasmodium_Vir PF05795.11 ETO07457.1 - 0.00022 20.8 0.2 0.00022 20.8 0.2 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein Orf78 PF06024.12 ETO07457.1 - 0.0006 20.1 0.5 0.001 19.3 0.5 1.3 1 0 0 1 1 1 1 Orf78 (ac78) DUF4448 PF14610.6 ETO07457.1 - 0.0017 18.1 0.0 0.0019 18.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TMEM154 PF15102.6 ETO07457.1 - 0.002 18.1 1.2 0.003 17.4 1.2 1.3 1 0 0 1 1 1 1 TMEM154 protein family DUF5305 PF17231.2 ETO07457.1 - 0.0031 16.9 0.2 0.0051 16.2 0.2 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF2520 PF10728.9 ETO07457.1 - 0.005 16.6 0.0 0.0089 15.8 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF2520) Glycophorin_A PF01102.18 ETO07457.1 - 0.0065 16.7 0.3 0.011 15.9 0.3 1.3 1 0 0 1 1 1 1 Glycophorin A CD34_antigen PF06365.12 ETO07457.1 - 0.0088 15.6 1.3 0.024 14.2 1.3 1.7 1 1 0 1 1 1 1 CD34/Podocalyxin family Amnionless PF14828.6 ETO07457.1 - 0.014 14.2 0.0 0.019 13.8 0.0 1.2 1 0 0 1 1 1 0 Amnionless RIFIN PF02009.16 ETO07457.1 - 0.029 14.3 0.1 0.03 14.2 0.1 1.2 1 0 0 1 1 1 0 Rifin Chordopox_A13L PF05961.11 ETO07457.1 - 0.038 14.2 0.6 0.1 12.8 0.4 2.0 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Peptidase_M56 PF05569.11 ETO07457.1 - 0.066 12.4 0.1 0.088 12.0 0.1 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 DAG1 PF05454.11 ETO07457.1 - 0.096 12.1 0.0 0.13 11.6 0.0 1.2 1 0 0 1 1 1 0 Dystroglycan (Dystrophin-associated glycoprotein 1) LRRC37AB_C PF14914.6 ETO07457.1 - 0.16 11.9 0.6 0.24 11.3 0.6 1.3 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain Homez PF11569.8 ETO07458.1 - 0.17 11.3 5.8 0.071 12.6 1.8 2.2 2 0 0 2 2 2 0 Homeodomain leucine-zipper encoding, Homez Pex14_N PF04695.13 ETO07461.1 - 0.00023 21.8 0.2 0.12 13.0 0.0 2.2 2 0 0 2 2 2 2 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF3446 PF11928.8 ETO07461.1 - 0.01 16.1 8.2 0.022 15.1 8.2 1.5 1 0 0 1 1 1 0 Early growth response N-terminal domain FA_desaturase PF00487.24 ETO07461.1 - 0.24 11.2 5.5 1 9.1 0.5 2.3 2 0 0 2 2 2 0 Fatty acid desaturase DUF3093 PF11292.8 ETO07461.1 - 0.33 11.2 7.0 0.04 14.2 1.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3093) Connexin PF00029.19 ETO07461.1 - 0.34 10.6 3.6 0.13 12.0 0.2 2.0 2 1 0 2 2 2 0 Connexin Ni_hydr_CYTB PF01292.20 ETO07461.1 - 0.78 9.3 9.0 3.1 7.4 8.1 2.4 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 zf-TRAF PF02176.18 ETO07462.1 - 3.6e-06 27.5 4.9 3.6e-06 27.5 4.9 2.8 4 0 0 4 4 4 1 TRAF-type zinc finger Fzo_mitofusin PF04799.13 ETO07462.1 - 0.011 15.3 3.9 0.011 15.3 3.9 1.9 2 0 0 2 2 2 0 fzo-like conserved region DUF1192 PF06698.11 ETO07462.1 - 0.54 10.4 4.6 0.32 11.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Uso1_p115_C PF04871.13 ETO07462.1 - 2.6 8.4 10.9 0.84 10.0 7.1 1.9 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Seryl_tRNA_N PF02403.22 ETO07462.1 - 4.5 7.6 14.2 0.99 9.7 10.0 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain RVT_1 PF00078.27 ETO07463.1 - 2.6e-10 40.2 0.0 7.4e-10 38.7 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Macoilin PF09726.9 ETO07463.1 - 2.1 6.8 12.1 3.5 6.1 12.1 1.2 1 0 0 1 1 1 0 Macoilin family Kinesin PF00225.23 ETO07464.1 - 1.2e-07 31.0 6.4 1.2e-07 31.0 6.4 1.6 1 1 1 2 2 2 1 Kinesin motor domain Peptidase_M15_2 PF05951.13 ETO07464.1 - 0.012 15.2 0.6 0.026 14.2 0.6 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF882) FKS1_dom1 PF14288.6 ETO07464.1 - 7.2 7.0 7.3 11 6.3 0.1 2.6 2 1 0 2 2 2 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Stealth_CR4 PF17103.5 ETO07465.1 - 0.068 13.1 0.6 0.18 11.7 0.6 1.6 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 Coilin_N PF15862.5 ETO07465.1 - 2.1 8.1 22.5 7.9 6.3 22.5 1.9 1 0 0 1 1 1 0 Coilin N-terminus DUF2929 PF11151.8 ETO07466.1 - 0.027 14.8 0.2 0.069 13.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2929) N_Asn_amidohyd PF14736.6 ETO07467.1 - 0.0079 15.4 0.0 0.014 14.6 0.0 1.5 1 1 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase Exo_endo_phos_2 PF14529.6 ETO07467.1 - 0.0082 16.0 5.4 0.0082 16.0 5.4 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Intimin_C PF07979.11 ETO07468.1 - 0.031 14.7 0.2 0.069 13.6 0.2 1.5 1 0 0 1 1 1 0 Intimin C-type lectin domain DUF3435 PF11917.8 ETO07468.1 - 3.5 6.5 16.0 1.8 7.4 8.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3435) TMEM154 PF15102.6 ETO07469.1 - 0.044 13.7 0.5 0.066 13.1 0.5 1.4 1 0 0 1 1 1 0 TMEM154 protein family PIRT PF15099.6 ETO07469.1 - 0.06 12.9 3.8 0.1 12.2 3.8 1.4 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family CDC45 PF02724.14 ETO07470.1 - 0.28 9.4 12.9 0.27 9.5 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DTHCT PF08070.11 ETO07470.1 - 0.68 10.7 29.3 30 5.4 28.6 2.4 1 1 1 2 2 2 0 DTHCT (NUC029) region Zip PF02535.22 ETO07470.1 - 1.9 7.6 5.2 1.9 7.7 5.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 ETO07470.1 - 5 5.1 13.7 5.6 4.9 13.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Connexin PF00029.19 ETO07471.1 - 0.03 14.1 5.2 0.049 13.4 5.2 1.3 1 0 0 1 1 1 0 Connexin Eapp_C PF10238.9 ETO07471.1 - 0.15 12.1 6.4 0.28 11.2 6.4 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein RNA_pol_Rpc4 PF05132.14 ETO07471.1 - 0.19 12.1 5.9 0.26 11.7 5.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF5604 PF18300.1 ETO07471.1 - 0.55 10.2 0.1 0.55 10.2 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5604) Zip PF02535.22 ETO07471.1 - 0.89 8.7 6.5 1.1 8.4 6.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Thiol_cytolys_C PF17440.2 ETO07471.1 - 2.3 8.4 7.1 0.15 12.3 1.5 2.0 2 1 1 3 3 3 0 Thiol-activated cytolysin beta sandwich domain Presenilin PF01080.17 ETO07471.1 - 5.3 5.7 7.9 5.3 5.7 7.9 1.1 1 0 0 1 1 1 0 Presenilin Methyltransf_11 PF08241.12 ETO07474.1 - 2e-17 63.6 0.0 2.6e-17 63.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO07474.1 - 3e-17 63.1 0.0 4e-17 62.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO07474.1 - 3.6e-10 39.8 0.0 3.9e-10 39.7 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO07474.1 - 5.1e-10 39.4 0.0 5.4e-10 39.3 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ETO07474.1 - 5.9e-10 39.1 0.0 7.9e-10 38.7 0.0 1.1 1 0 0 1 1 1 1 Nodulation protein S (NodS) TehB PF03848.14 ETO07474.1 - 6.9e-10 38.7 0.0 7.7e-10 38.5 0.0 1.1 1 0 0 1 1 1 1 Tellurite resistance protein TehB Methyltransf_12 PF08242.12 ETO07474.1 - 5.1e-09 36.8 0.0 7.1e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_PK PF05891.12 ETO07474.1 - 1.7e-06 27.8 0.0 1.9e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase CheR PF01739.18 ETO07474.1 - 0.001 18.6 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 CheR methyltransferase, SAM binding domain MTS PF05175.14 ETO07474.1 - 0.0021 17.6 0.0 0.0028 17.2 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ETO07474.1 - 0.0041 16.5 0.0 0.0054 16.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ETO07474.1 - 0.018 14.5 0.0 0.028 13.9 0.0 1.3 1 0 0 1 1 1 0 Putative methyltransferase tRNA_U5-meth_tr PF05958.11 ETO07474.1 - 0.03 13.3 0.0 0.043 12.8 0.0 1.3 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase Nucleoporin_N PF08801.11 ETO07475.1 - 0.0018 17.1 0.7 0.013 14.3 0.1 1.9 2 0 0 2 2 2 1 Nup133 N terminal like WD40 PF00400.32 ETO07475.1 - 0.0025 18.6 2.9 0.0052 17.6 1.4 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat PHP_C PF13263.6 ETO07476.1 - 0.066 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 PHP-associated XK-related PF09815.9 ETO07477.1 - 0.00056 19.1 8.3 0.00096 18.3 8.3 1.4 1 1 0 1 1 1 1 XK-related protein DUF2729 PF10870.8 ETO07478.1 - 0.08 12.8 0.1 0.95 9.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2729) tRNA_synt_1c_R2 PF04557.15 ETO07479.1 - 0.0033 18.3 5.9 0.0039 18.1 5.9 1.2 1 0 0 1 1 1 1 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Eapp_C PF10238.9 ETO07479.1 - 0.092 12.8 1.3 0.1 12.6 1.3 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Hemopexin PF00045.19 ETO07480.1 - 0.048 13.6 0.9 0.28 11.2 0.0 2.8 3 0 0 3 3 3 0 Hemopexin WD40 PF00400.32 ETO07483.1 - 6.4e-39 131.2 22.5 1.5e-06 28.8 0.2 7.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07483.1 - 1.3e-09 38.2 2.9 0.36 11.1 0.2 6.1 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07483.1 - 2.6e-09 36.3 10.4 0.039 12.6 0.2 5.5 1 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07483.1 - 7.3e-07 28.8 11.6 9.4e-05 21.9 0.7 4.9 3 2 1 5 5 5 3 WD40-like domain ERM PF00769.19 ETO07483.1 - 2.9e-06 27.3 21.5 2.9e-06 27.3 21.5 1.7 2 0 0 2 2 2 1 Ezrin/radixin/moesin family Macoilin PF09726.9 ETO07483.1 - 0.54 8.7 34.0 0.92 8.0 34.0 1.3 1 0 0 1 1 1 0 Macoilin family Kelch_2 PF07646.15 ETO07483.1 - 1.6 8.8 5.9 12 6.1 0.1 4.1 4 0 0 4 4 4 0 Kelch motif Pullulanase_Ins PF18494.1 ETO07483.1 - 2.8 8.5 9.3 0.19 12.2 0.9 3.4 2 1 1 3 3 3 0 Pullulanase Ins domain DUF3935 PF13071.6 ETO07484.1 - 0.095 13.2 1.7 0.25 11.9 1.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3935) Ank_2 PF12796.7 ETO07486.1 - 1.8e-12 47.7 0.1 6.8e-09 36.2 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO07486.1 - 2.9e-09 37.0 0.0 0.0032 17.8 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETO07486.1 - 5.3e-08 32.5 0.0 0.083 13.5 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat CTK3 PF12243.8 ETO07486.1 - 6.9e-06 26.1 0.3 9.6e-06 25.6 0.3 1.3 1 0 0 1 1 1 1 CTD kinase subunit gamma CTK3 Ank_5 PF13857.6 ETO07486.1 - 1.1e-05 25.6 0.1 0.18 12.1 0.0 3.3 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO07486.1 - 0.00028 21.4 0.1 0.0044 17.6 0.0 2.6 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Fanconi_A PF03511.14 ETO07486.1 - 0.06 13.3 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Fanconi anaemia group A protein Beach PF02138.18 ETO07487.1 - 2.4e-122 407.7 0.0 4.9e-122 406.6 0.0 1.6 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO07487.1 - 1.3e-16 60.5 0.9 1.2e-12 47.7 0.5 3.5 2 1 0 2 2 2 2 PH domain associated with Beige/BEACH PH PF00169.29 ETO07487.1 - 1.6e-07 31.8 0.7 6.6e-07 29.8 0.7 2.2 1 0 0 1 1 1 1 PH domain Actin PF00022.19 ETO07489.1 - 5.1e-12 45.1 0.0 6e-12 44.9 0.0 1.3 1 0 0 1 1 1 1 Actin GTP_EFTU PF00009.27 ETO07489.1 - 0.0058 16.2 0.1 0.018 14.6 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain DUF938 PF06080.12 ETO07490.1 - 0.045 13.5 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF938) RRXRR PF14239.6 ETO07490.1 - 0.24 11.3 4.3 0.61 9.9 4.3 1.6 1 0 0 1 1 1 0 RRXRR protein Methylase_S PF01420.19 ETO07491.1 - 0.009 16.3 0.8 0.015 15.5 0.8 1.3 1 0 0 1 1 1 1 Type I restriction modification DNA specificity domain WW PF00397.26 ETO07492.1 - 3.5e-10 39.8 5.4 7.4e-09 35.5 4.5 2.5 2 0 0 2 2 2 1 WW domain Myosin_N PF02736.19 ETO07492.1 - 0.022 14.6 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 Myosin N-terminal SH3-like domain GYF_2 PF14237.6 ETO07492.1 - 0.12 12.3 0.0 0.24 11.2 0.0 1.7 1 0 0 1 1 1 0 GYF domain 2 Rad51 PF08423.11 ETO07493.1 - 1.1e-107 359.1 0.1 1.4e-107 358.7 0.1 1.1 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 ETO07493.1 - 9.1e-11 41.7 0.2 1.3e-10 41.2 0.2 1.1 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 ETO07493.1 - 3.2e-07 29.9 0.0 5.5e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 KaiC AAA_25 PF13481.6 ETO07493.1 - 2e-06 27.5 0.0 2.9e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 ETO07493.1 - 0.0001 22.8 0.0 0.00031 21.3 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain HhH-GPD PF00730.25 ETO07493.1 - 0.031 14.7 0.0 0.055 13.9 0.0 1.7 1 1 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein Csm4_C PF17953.1 ETO07493.1 - 0.14 12.0 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 CRISPR Csm4 C-terminal domain FHA PF00498.26 ETO07494.1 - 3.7e-12 46.4 0.9 3.7e-12 46.4 0.9 2.0 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 ETO07494.1 - 0.013 15.8 0.0 0.028 14.7 0.0 1.5 1 0 0 1 1 1 0 Inner membrane component of T3SS, cytoplasmic domain AAA_7 PF12775.7 ETO07495.1 - 0.0036 16.9 1.1 0.027 14.0 0.0 2.6 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA PF00004.29 ETO07495.1 - 0.08 13.4 0.1 5.4 7.5 0.0 3.0 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) WD40 PF00400.32 ETO07496.1 - 2.6e-65 214.7 21.2 9.1e-10 39.0 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07496.1 - 2.4e-29 101.4 2.6 8.9e-06 25.9 0.1 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07496.1 - 2e-15 56.6 0.5 0.00082 18.4 0.1 6.5 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO07496.1 - 3.8e-10 39.6 1.5 0.029 13.7 0.3 3.4 2 2 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO07496.1 - 8e-10 38.0 3.4 0.58 8.7 0.0 5.5 1 1 5 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO07496.1 - 1e-06 27.6 0.0 0.0028 16.3 0.0 2.6 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO07496.1 - 3.3e-06 26.1 7.9 0.14 10.8 0.1 5.2 1 1 4 5 5 5 3 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO07496.1 - 1e-05 24.8 0.6 0.03 13.4 0.2 2.4 1 1 1 2 2 2 2 Coatomer WD associated region Ricin_B_lectin PF00652.22 ETO07496.1 - 1.3e-05 25.4 6.3 0.028 14.7 0.1 3.4 2 2 1 3 3 3 3 Ricin-type beta-trefoil lectin domain PQQ_2 PF13360.6 ETO07496.1 - 9.2e-05 22.1 0.1 0.00085 19.0 0.1 2.4 1 1 0 1 1 1 1 PQQ-like domain MMS1_N PF10433.9 ETO07496.1 - 0.00033 19.4 0.2 0.039 12.6 0.0 3.0 2 1 2 4 4 4 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term PD40 PF07676.12 ETO07496.1 - 0.00043 20.1 4.4 3.7 7.6 0.0 4.9 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat NHL PF01436.21 ETO07496.1 - 0.00091 19.2 3.4 2.7 8.2 0.1 3.8 3 0 0 3 3 3 1 NHL repeat Nbas_N PF15492.6 ETO07496.1 - 0.00091 18.6 0.7 0.75 9.1 0.0 3.7 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO07496.1 - 0.0028 16.5 0.0 9.1 4.9 0.0 3.8 2 2 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO07496.1 - 0.0037 17.1 0.0 15 5.7 0.0 4.6 5 0 0 5 5 5 0 PQQ enzyme repeat VID27 PF08553.10 ETO07496.1 - 0.0055 15.8 0.0 0.24 10.4 0.0 2.7 2 1 1 3 3 3 1 VID27 C-terminal WD40-like domain Utp8 PF10395.9 ETO07496.1 - 0.03 12.8 0.0 0.39 9.2 0.0 2.2 1 1 1 2 2 2 0 Utp8 family DUF5449 PF17528.2 ETO07496.1 - 0.031 14.0 0.0 12 5.6 0.0 3.6 2 1 1 4 4 4 0 Family of unknown function (DUF5449) zf-C6H2 PF15801.5 ETO07496.1 - 0.11 12.8 0.2 2.2 8.6 0.0 2.4 2 0 0 2 2 2 0 zf-MYND-like zinc finger, mRNA-binding Proteasome_A_N PF10584.9 ETO07496.1 - 0.21 11.3 6.7 3.4 7.4 0.1 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO07497.1 - 9.9e-05 22.5 1.7 0.28 11.5 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO07497.1 - 0.00011 21.7 0.7 2 8.0 0.0 4.2 4 0 0 4 4 4 3 Kelch motif WD40 PF00400.32 ETO07498.1 - 5.4e-33 112.5 20.4 5.1e-06 27.1 0.4 5.9 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07498.1 - 1.7e-12 47.5 1.4 0.021 15.1 0.0 4.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07498.1 - 7.8e-10 38.0 6.4 0.019 13.7 0.1 4.5 1 1 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07498.1 - 7.1e-07 28.8 9.4 0.0043 16.4 0.3 3.8 3 1 0 4 4 4 3 WD40-like domain zf-TRAF PF02176.18 ETO07498.1 - 0.0028 18.3 5.3 0.0086 16.8 5.3 1.9 1 0 0 1 1 1 1 TRAF-type zinc finger YabA PF06156.13 ETO07498.1 - 0.019 15.6 7.4 0.019 15.6 7.4 3.4 2 1 1 3 3 3 0 Initiation control protein YabA Nrf1_activ_bdg PF10492.9 ETO07498.1 - 0.068 13.8 0.0 0.2 12.3 0.0 1.7 1 0 0 1 1 1 0 Nrf1 activator activation site binding domain DnaJ PF00226.31 ETO07499.1 - 0.00014 21.9 1.3 0.00031 20.8 1.3 1.6 1 0 0 1 1 1 1 DnaJ domain Ank_2 PF12796.7 ETO07500.1 - 2e-09 37.9 0.5 1.3e-06 28.9 0.1 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO07500.1 - 1.1e-07 32.0 0.0 0.0014 19.0 0.0 3.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 ETO07500.1 - 2.5e-07 30.4 0.1 0.0093 16.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO07500.1 - 3.7e-06 27.1 0.3 0.0011 19.2 0.1 3.0 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO07500.1 - 0.007 16.9 0.5 1.6 9.4 0.0 3.3 2 1 1 3 3 3 1 Ankyrin repeats (many copies) HTH_25 PF13413.6 ETO07500.1 - 0.092 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Helix-turn-helix domain Acetyltransf_10 PF13673.7 ETO07501.1 - 2.8e-10 40.2 0.1 3e-10 40.1 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO07501.1 - 5.4e-08 33.2 0.1 6.9e-08 32.8 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO07501.1 - 7.8e-08 32.6 0.0 9.1e-08 32.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ETO07501.1 - 0.032 14.3 0.0 0.044 13.9 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CCM2_C PF16545.5 ETO07501.1 - 0.049 14.2 0.1 0.058 13.9 0.1 1.2 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology A_deaminase PF00962.22 ETO07502.1 - 1.4e-30 106.7 0.0 3e-30 105.7 0.0 1.5 1 0 0 1 1 1 1 Adenosine/AMP deaminase A_deaminase PF00962.22 ETO07503.1 - 4.8e-20 72.1 0.0 5.8e-20 71.9 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase RRXRR PF14239.6 ETO07504.1 - 0.0054 16.6 3.7 0.0061 16.4 3.7 1.2 1 0 0 1 1 1 1 RRXRR protein DUF4812 PF16071.5 ETO07504.1 - 0.068 13.0 0.1 0.21 11.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4812) 7tm_1 PF00001.21 ETO07505.1 - 0.019 14.3 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Syndecan PF01034.20 ETO07505.1 - 0.019 14.9 3.7 0.055 13.4 3.7 1.8 1 0 0 1 1 1 0 Syndecan domain SMRP1 PF15181.6 ETO07506.1 - 0.11 12.1 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Spermatid-specific manchette-related protein 1 EVI2A PF05399.11 ETO07507.1 - 0.019 14.6 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) PsbL PF02419.17 ETO07508.1 - 0.16 12.0 1.7 0.4 10.7 1.7 1.7 1 0 0 1 1 1 0 PsbL protein Tubulin PF00091.25 ETO07509.1 - 3.1e-21 76.5 0.0 1e-14 55.2 0.0 2.2 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO07509.1 - 0.00015 21.9 0.0 0.00027 21.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain DRE2_N PF16803.5 ETO07509.1 - 0.025 14.8 0.0 2.7 8.3 0.0 2.2 2 0 0 2 2 2 0 Fe-S cluster assembly protein DRE2 N-terminus Lipase_3 PF01764.25 ETO07509.1 - 0.035 14.0 0.0 0.048 13.5 0.0 1.3 1 0 0 1 1 1 0 Lipase (class 3) PUB PF09409.10 ETO07510.1 - 9.4e-05 22.3 1.4 0.0002 21.3 1.4 1.6 1 1 0 1 1 1 1 PUB domain PCI PF01399.27 ETO07510.1 - 2.3 8.8 9.0 0.73 10.4 0.7 2.8 1 1 2 3 3 3 0 PCI domain ABC_membrane PF00664.23 ETO07511.1 - 1.8e-10 40.9 0.0 1.8e-10 40.9 0.0 2.8 3 0 0 3 3 3 2 ABC transporter transmembrane region C1_2 PF03107.16 ETO07512.1 - 6.5e-08 32.8 8.0 6.5e-08 32.8 8.0 2.2 2 0 0 2 2 2 1 C1 domain ABC_membrane PF00664.23 ETO07512.1 - 6.8e-06 25.9 1.3 6.8e-06 25.9 1.3 3.1 3 1 0 3 3 3 1 ABC transporter transmembrane region ZZ PF00569.17 ETO07512.1 - 0.0048 16.7 8.4 0.012 15.4 8.4 1.7 1 0 0 1 1 1 1 Zinc finger, ZZ type 7TM_GPCR_Srv PF10323.9 ETO07512.1 - 0.011 15.1 0.7 0.011 15.1 0.7 4.1 4 1 0 4 4 4 0 Serpentine type 7TM GPCR chemoreceptor Srv Coatamer_beta_C PF07718.12 ETO07513.1 - 6.6e-52 175.1 0.3 6.6e-52 175.1 0.3 2.2 2 0 0 2 2 2 1 Coatomer beta C-terminal region Coatomer_b_Cpla PF14806.6 ETO07513.1 - 8.7e-48 161.5 5.4 6.7e-41 139.3 0.6 2.7 3 0 0 3 3 3 2 Coatomer beta subunit appendage platform Coatomer_g_Cpla PF16381.5 ETO07513.1 - 0.0042 17.2 0.2 0.017 15.2 0.0 2.1 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform DUF916 PF06030.12 ETO07513.1 - 0.053 13.6 1.1 0.32 11.1 0.0 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF916) DnaJ PF00226.31 ETO07514.1 - 5.6e-15 55.2 2.8 6e-13 48.7 2.8 2.6 1 1 0 1 1 1 1 DnaJ domain BRD4_CDT PF17105.5 ETO07514.1 - 0.55 9.9 0.0 0.55 9.9 0.0 3.0 3 0 0 3 3 3 0 C-terminal domain of bromodomain protein 4 Pkinase PF00069.25 ETO07515.1 - 1.3e-59 201.7 0.1 9.4e-59 198.9 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO07515.1 - 5.5e-29 101.2 0.1 1.6e-28 99.7 0.0 1.8 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO07515.1 - 3e-06 26.7 0.1 4.8e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO07515.1 - 0.0005 20.1 0.8 0.026 14.5 0.1 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO07515.1 - 0.052 12.9 0.0 0.087 12.1 0.0 1.3 1 0 0 1 1 1 0 Kinase-like ABC_tran PF00005.27 ETO07517.1 - 3.8e-14 53.4 0.4 9.4e-12 45.6 0.0 3.0 2 2 0 2 2 2 1 ABC transporter SbcCD_C PF13558.6 ETO07517.1 - 0.034 14.4 0.4 0.3 11.4 0.4 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit DUF5580 PF17743.1 ETO07518.1 - 6.3 5.2 15.3 0.007 15.0 3.4 1.9 2 1 0 2 2 2 0 Family of unknown function (DUF5580) DUF1640 PF07798.11 ETO07519.1 - 0.55 10.3 7.6 0.74 9.8 7.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Nop14 PF04147.12 ETO07520.1 - 0.24 9.6 10.8 0.33 9.1 10.8 1.2 1 0 0 1 1 1 0 Nop14-like family DUF4746 PF15928.5 ETO07520.1 - 1.4 8.3 12.7 0.2 11.0 8.8 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) MIP PF00230.20 ETO07521.1 - 1.4e-18 67.4 0.6 4.3e-18 65.9 0.6 1.7 1 1 0 1 1 1 1 Major intrinsic protein Aminotran_1_2 PF00155.21 ETO07522.1 - 5.4e-78 262.7 0.0 6.8e-78 262.4 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II CAP_C PF08603.11 ETO07523.1 - 2.7e-29 101.8 14.9 4.4e-29 101.1 14.9 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ETO07523.1 - 6e-08 32.5 12.7 1.3e-07 31.3 12.7 1.7 1 1 0 1 1 1 1 Tubulin binding cofactor C FAD_binding_1 PF00667.20 ETO07523.1 - 0.0065 16.1 0.1 0.013 15.1 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain EIIBC-GUT_N PF03612.14 ETO07523.1 - 0.28 10.9 3.3 0.11 12.3 0.6 1.7 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus zf-TFIIB PF13453.6 ETO07523.1 - 4.8 6.6 5.3 4.6 6.7 0.2 3.0 3 0 0 3 3 3 0 Transcription factor zinc-finger SAM_2 PF07647.17 ETO07526.1 - 3.2e-07 30.4 0.1 0.0038 17.3 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO07526.1 - 5.2e-05 23.6 0.0 0.41 11.1 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) KorB PF08535.10 ETO07527.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 KorB domain CorA PF01544.18 ETO07528.1 - 7.2e-31 107.6 0.0 7.2e-31 107.6 0.0 3.0 4 0 0 4 4 4 1 CorA-like Mg2+ transporter protein La_HTH_kDCL PF18177.1 ETO07528.1 - 0.053 13.8 0.0 0.18 12.1 0.0 1.9 1 0 0 1 1 1 0 La HTH in kinetoplastid DICER domain Usp PF00582.26 ETO07529.1 - 6.2e-19 68.9 0.3 5e-18 66.0 0.3 2.0 1 1 0 1 1 1 1 Universal stress protein family DUF460 PF04312.13 ETO07529.1 - 0.0026 17.4 0.3 1.7 8.3 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF460) BKACE PF05853.12 ETO07529.1 - 0.019 14.3 0.0 0.023 14.0 0.0 1.1 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme WD40 PF00400.32 ETO07530.1 - 8.9e-09 35.9 10.5 1.6e-05 25.5 2.6 3.5 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO07530.1 - 0.0095 14.6 0.2 1.2 7.7 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Read-through PF16814.5 ETO07530.1 - 0.027 14.3 1.9 0.056 13.2 0.6 1.8 1 1 0 2 2 2 0 Read-through domain DUF2604 PF10790.9 ETO07531.1 - 0.24 11.7 1.2 0.42 10.9 1.2 1.3 1 0 0 1 1 1 0 Protein of Unknown function (DUF2604) Macoilin PF09726.9 ETO07532.1 - 1.6 7.2 18.8 2.7 6.4 18.8 1.5 1 0 0 1 1 1 0 Macoilin family POPLD PF08170.12 ETO07532.1 - 1.7 9.0 12.3 0.083 13.2 3.3 3.1 3 0 0 3 3 3 0 POPLD (NUC188) domain Trypan_PARP PF05887.11 ETO07532.1 - 1.7 8.6 32.0 2.2 8.3 25.1 3.2 2 1 1 3 3 3 0 Procyclic acidic repetitive protein (PARP) Receptor_2B4 PF11465.8 ETO07533.1 - 0.13 12.5 0.8 0.23 11.7 0.6 1.6 1 1 0 1 1 1 0 Natural killer cell receptor 2B4 WD40 PF00400.32 ETO07534.1 - 4e-31 106.6 33.3 2.3e-06 28.2 2.5 6.9 6 2 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO07534.1 - 6.1e-09 35.1 3.6 0.0014 17.4 0.6 3.9 1 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07534.1 - 3.4e-06 27.3 0.9 4.5 7.6 0.0 4.0 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07534.1 - 8.6e-05 22.0 1.2 0.049 13.0 0.1 3.1 2 1 0 3 3 3 2 WD40-like domain FtsL PF04999.13 ETO07535.1 - 0.011 15.7 1.5 0.034 14.1 0.2 2.2 2 0 0 2 2 2 0 Cell division protein FtsL ATP13 PF12921.7 ETO07537.1 - 0.0042 16.9 0.3 1.6 8.6 0.0 2.4 2 0 0 2 2 2 2 Mitochondrial ATPase expression Mrr_N PF14338.6 ETO07538.1 - 0.022 14.9 0.2 0.061 13.5 0.0 1.8 2 0 0 2 2 2 0 Mrr N-terminal domain SDA1 PF05285.12 ETO07539.1 - 0.00073 19.1 17.3 0.00079 18.9 17.3 1.1 1 0 0 1 1 1 1 SDA1 PrgU PF09627.10 ETO07539.1 - 0.018 15.0 0.4 0.034 14.1 0.4 1.6 1 1 0 1 1 1 0 PrgU-like protein RRM_1 PF00076.22 ETO07539.1 - 0.051 13.4 0.0 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) GBP PF02263.19 ETO07540.1 - 0.05 12.9 1.0 0.053 12.8 1.0 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, N-terminal domain Ceramidase PF05875.12 ETO07542.1 - 6.1e-52 176.6 17.7 8.1e-52 176.2 17.7 1.1 1 0 0 1 1 1 1 Ceramidase Ezh2_MCSS PF18600.1 ETO07542.1 - 5.9 6.6 7.3 8 6.2 0.9 2.5 2 0 0 2 2 2 0 MCSS domain Presenilin PF01080.17 ETO07543.1 - 0.018 13.8 0.4 0.02 13.7 0.4 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 ETO07543.1 - 0.025 13.6 0.5 0.034 13.2 0.5 1.2 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 ETO07543.1 - 0.12 11.6 0.2 0.13 11.5 0.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TAF4 PF05236.14 ETO07543.1 - 1.2 8.9 15.9 1.6 8.4 15.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Membralin PF09746.9 ETO07543.1 - 2.6 7.0 5.4 3.4 6.6 5.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF3807 PF12720.7 ETO07543.1 - 3.6 7.8 19.2 5.2 7.3 19.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Sec62 PF03839.16 ETO07543.1 - 4 6.9 17.0 6.5 6.2 17.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 BORG_CEP PF14957.6 ETO07543.1 - 7.1 7.8 13.1 12 7.1 13.1 1.4 1 1 0 1 1 1 0 Cdc42 effector WD40 PF00400.32 ETO07545.1 - 1.9e-37 126.6 23.2 1.5e-06 28.8 0.1 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07545.1 - 1.4e-09 38.2 0.7 0.14 12.5 0.1 5.4 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07545.1 - 1.5e-09 37.1 6.0 0.032 12.9 0.0 4.9 2 2 2 5 5 4 4 Nucleoporin Nup120/160 HARP PF07443.13 ETO07545.1 - 0.12 12.1 0.0 6.7 6.4 0.0 3.1 3 0 0 3 3 3 0 HepA-related protein (HARP) RCC1_2 PF13540.6 ETO07547.1 - 8.4e-09 35.0 1.2 1.1e-06 28.3 0.0 2.7 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat EpCAM_N PF18635.1 ETO07547.1 - 0.17 12.1 2.1 0.43 10.8 2.1 1.6 1 0 0 1 1 1 0 Epithelial cell adhesion molecule N-terminal domain WD40 PF00400.32 ETO07548.1 - 5.8e-09 36.4 18.7 1.4e-05 25.7 0.9 5.1 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07548.1 - 0.00031 19.5 3.8 0.014 14.1 1.1 2.5 2 1 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07548.1 - 0.00032 20.9 2.8 2.8 8.3 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF3122 PF11320.8 ETO07548.1 - 0.12 12.4 0.5 0.2 11.7 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3122) WD40 PF00400.32 ETO07551.1 - 2.7e-34 116.6 0.2 1.3e-10 41.7 0.2 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07551.1 - 3.6e-11 43.2 0.5 0.00027 21.2 0.1 3.8 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07551.1 - 2.5e-09 36.6 0.0 0.01 14.8 0.0 3.4 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO07551.1 - 3.9e-06 26.9 0.0 0.00019 21.4 0.0 1.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO07551.1 - 0.00062 19.2 0.1 0.024 13.9 0.0 2.0 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO07551.1 - 0.0021 16.8 3.1 0.75 8.4 0.0 3.6 1 1 2 4 4 4 2 Nucleoporin Nup120/160 GATase PF00117.28 ETO07551.1 - 0.011 15.6 0.0 18 5.1 0.0 3.0 1 1 2 3 3 3 0 Glutamine amidotransferase class-I Cytochrom_D1 PF02239.16 ETO07551.1 - 0.017 13.7 0.1 0.028 12.9 0.0 1.3 1 1 0 1 1 1 0 Cytochrome D1 heme domain Phage_CI_repr PF07022.13 ETO07551.1 - 0.023 14.8 0.0 0.62 10.2 0.0 2.3 2 1 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain ROS_MUCR PF05443.11 ETO07551.1 - 0.048 13.7 0.0 2.9 7.9 0.0 2.3 1 1 1 2 2 2 0 ROS/MUCR transcriptional regulator protein Nucleoporin_N PF08801.11 ETO07551.1 - 0.049 12.4 0.4 11 4.6 0.2 2.9 1 1 2 3 3 3 0 Nup133 N terminal like PD40 PF07676.12 ETO07551.1 - 0.11 12.4 0.1 2.5 8.1 0.0 2.8 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Kelch_6 PF13964.6 ETO07552.1 - 2.1e-06 27.8 2.1 0.11 12.8 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO07552.1 - 0.00061 19.8 0.1 0.0059 16.6 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07552.1 - 0.0011 18.8 0.9 0.27 11.3 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO07552.1 - 0.0027 17.7 0.6 1.1 9.3 0.2 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO07552.1 - 0.064 13.6 0.0 0.87 10.0 0.0 2.7 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO07552.1 - 0.084 12.5 5.8 0.66 9.6 0.1 4.3 5 1 0 5 5 5 0 Kelch motif F-box-like PF12937.7 ETO07553.1 - 0.00065 19.5 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO07553.1 - 0.048 13.6 1.1 0.13 12.2 0.1 2.1 2 0 0 2 2 2 0 F-box domain DUF2018 PF09442.10 ETO07554.1 - 0.038 14.9 0.5 0.076 14.0 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2018) TIP120 PF08623.10 ETO07554.1 - 0.076 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) WD40 PF00400.32 ETO07555.1 - 1.4e-12 47.9 13.0 0.0015 19.3 2.0 6.7 6 2 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07555.1 - 1.5e-05 25.2 1.0 0.8 10.0 0.0 4.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain AHSP PF09236.10 ETO07555.1 - 0.021 15.2 1.0 0.049 14.1 1.0 1.6 1 0 0 1 1 1 0 Alpha-haemoglobin stabilising protein Fzo_mitofusin PF04799.13 ETO07555.1 - 0.14 11.7 3.8 0.32 10.5 3.8 1.6 1 0 0 1 1 1 0 fzo-like conserved region SMC_N PF02463.19 ETO07556.1 - 2e-25 89.5 0.0 2.9e-25 89.0 0.0 1.3 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO07556.1 - 0.031 14.1 0.0 0.047 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system WD40 PF00400.32 ETO07558.1 - 2.5e-36 123.0 27.0 6e-07 30.1 0.1 7.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07558.1 - 6.1e-10 39.3 3.2 0.11 12.8 0.1 5.8 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07558.1 - 2.3e-06 26.5 7.4 0.016 13.9 0.7 4.3 3 2 1 4 4 4 4 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO07559.1 - 1e-05 25.6 0.3 0.024 14.9 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO07559.1 - 0.00018 21.5 0.1 0.0062 16.5 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO07559.1 - 0.012 15.2 0.1 0.042 13.4 0.0 2.0 2 0 0 2 2 2 0 Kelch motif DUF4335 PF14233.6 ETO07559.1 - 0.069 13.1 0.4 0.51 10.2 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4335) Kelch_2 PF07646.15 ETO07559.1 - 0.1 12.6 6.7 0.6 10.2 0.1 4.3 5 1 0 5 5 5 0 Kelch motif Peptidase_S49_N PF08496.10 ETO07559.1 - 7.8 6.5 9.7 2.1 8.4 6.0 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ribosomal_L29e PF01779.17 ETO07560.1 - 0.0082 16.5 1.4 0.0082 16.5 1.4 2.2 2 0 0 2 2 2 1 Ribosomal L29e protein family Tir_receptor_C PF07489.11 ETO07560.1 - 0.01 15.8 1.1 0.01 15.8 1.1 1.9 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus CCDC-167 PF15188.6 ETO07560.1 - 0.28 11.6 3.5 0.56 10.6 3.5 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 REPA_OB_2 PF16900.5 ETO07561.1 - 3.5e-13 49.3 0.0 5.9e-13 48.6 0.0 1.4 1 0 0 1 1 1 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ETO07561.1 - 0.0059 16.6 0.1 0.018 15.1 0.0 1.9 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain Kelch_2 PF07646.15 ETO07563.1 - 9.4e-07 28.6 1.5 0.032 14.2 0.1 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO07563.1 - 1e-06 28.2 2.3 0.0012 18.4 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO07563.1 - 3.5e-06 27.1 4.2 0.19 12.1 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO07563.1 - 0.0023 17.9 4.6 0.66 10.0 0.1 4.8 5 0 0 5 5 5 1 Kelch motif MAJIN PF15077.6 ETO07563.1 - 0.13 12.0 0.3 0.23 11.2 0.3 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein Kelch_3 PF13415.6 ETO07563.1 - 0.36 11.2 2.4 7.6 6.9 0.0 3.5 4 1 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO07564.1 - 4.8e-09 36.7 9.4 0.0059 17.4 0.1 4.0 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07564.1 - 0.00093 18.0 1.0 0.0051 15.5 0.1 1.9 1 1 0 2 2 2 1 Nucleoporin Nup120/160 BChl_A PF02327.17 ETO07565.1 - 0.076 11.8 0.6 0.094 11.5 0.6 1.1 1 0 0 1 1 1 0 Bacteriochlorophyll A protein DUF243 PF03103.17 ETO07566.1 - 0.047 14.0 2.1 0.058 13.7 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF243) DDRGK PF09756.9 ETO07568.1 - 0.14 11.8 21.9 0.14 11.7 21.9 1.0 1 0 0 1 1 1 0 DDRGK domain DUF1764 PF08576.10 ETO07568.1 - 1.1 10.3 22.2 1.3 10.0 22.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) DUF3807 PF12720.7 ETO07568.1 - 3.9 7.7 24.6 4.4 7.5 24.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Tyrosinase PF00264.20 ETO07568.1 - 7.4 6.8 14.9 7.7 6.7 14.9 1.0 1 0 0 1 1 1 0 Common central domain of tyrosinase V_ATPase_I PF01496.19 ETO07568.1 - 7.8 4.3 19.6 8.1 4.2 19.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Ureide_permease PF07168.11 ETO07569.1 - 1.1 8.0 3.9 2.4 6.8 3.9 1.5 1 0 0 1 1 1 0 Ureide permease DUF3573 PF12097.8 ETO07571.1 - 0.016 14.1 1.0 0.018 13.9 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) HlyC PF02794.16 ETO07571.1 - 0.04 13.8 0.4 0.14 12.0 0.1 2.1 2 1 0 2 2 2 0 RTX toxin acyltransferase family DUF5411 PF17424.2 ETO07571.1 - 0.11 12.5 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5411) WD40 PF00400.32 ETO07573.1 - 0.0011 19.7 0.2 0.0037 18.1 0.2 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat Spt20 PF12090.8 ETO07573.1 - 0.054 13.1 1.6 0.074 12.7 1.6 1.1 1 0 0 1 1 1 0 Spt20 family RHD3 PF05879.12 ETO07574.1 - 1.2e-05 23.7 13.1 7.6e-05 21.1 0.0 2.5 2 1 0 2 2 2 2 Root hair defective 3 GTP-binding protein (RHD3) Dynamin_N PF00350.23 ETO07574.1 - 0.065 13.3 2.4 0.18 11.8 0.0 2.6 2 1 0 2 2 2 0 Dynamin family CorA PF01544.18 ETO07574.1 - 2 7.6 13.7 0.17 11.1 6.5 2.4 2 1 1 3 3 3 0 CorA-like Mg2+ transporter protein WD40 PF00400.32 ETO07575.1 - 1.1e-12 48.2 10.4 4.3e-06 27.4 0.8 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO07575.1 - 5.8e-05 21.9 1.3 0.035 12.7 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07575.1 - 0.0057 16.0 1.1 0.02 14.2 1.1 1.8 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO07575.1 - 0.02 15.2 0.1 0.25 11.7 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO07575.1 - 0.069 12.7 3.2 0.11 12.0 3.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4221) DUF4874 PF16173.5 ETO07576.1 - 0.029 14.0 0.1 0.05 13.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4874) Longin_2 PF18639.1 ETO07579.1 - 0.064 13.1 2.8 0.41 10.5 2.7 2.2 1 1 0 1 1 1 0 Yeast longin domain TPR_12 PF13424.6 ETO07580.1 - 5.2e-22 77.9 4.3 2.4e-14 53.4 0.3 3.6 1 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07580.1 - 6e-13 48.2 4.1 9.4e-05 22.2 0.0 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07580.1 - 1.7e-10 40.3 16.1 0.00057 19.6 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07580.1 - 1e-09 37.7 3.2 0.0016 18.3 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07580.1 - 1.7e-07 30.8 12.2 0.019 15.0 0.1 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07580.1 - 3.1e-06 27.0 9.8 0.097 12.9 0.1 4.1 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO07580.1 - 0.00026 21.0 0.3 0.1 12.7 0.1 2.8 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO07580.1 - 0.12 12.8 1.3 31 5.2 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 ETO07580.1 - 0.12 11.7 4.3 0.84 9.0 0.1 2.9 4 0 0 4 4 4 0 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO07580.1 - 0.41 10.4 7.0 1.8 8.3 0.0 3.4 3 1 1 4 4 4 0 TPR repeat CD45 PF12567.8 ETO07580.1 - 8.8 6.4 9.1 2 8.5 0.5 3.6 3 0 0 3 3 3 0 Leukocyte receptor CD45 Ank_3 PF13606.6 ETO07581.1 - 0.028 14.9 0.4 0.11 13.1 0.1 2.0 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 ETO07581.1 - 0.061 13.9 0.1 0.13 12.9 0.0 1.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Mucin PF01456.17 ETO07581.1 - 4.9 7.1 26.1 6.7 6.7 26.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein LRR_4 PF12799.7 ETO07583.1 - 2.2e-15 56.5 29.3 0.00028 21.2 1.5 6.0 3 1 4 7 7 7 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO07583.1 - 1.6e-11 43.8 26.4 2.8e-05 23.8 4.5 6.0 3 3 1 4 4 4 4 Leucine rich repeat LRR_1 PF00560.33 ETO07583.1 - 1.4e-10 40.2 18.8 1.5 9.6 0.1 8.6 7 1 0 7 7 7 4 Leucine Rich Repeat LRR_6 PF13516.6 ETO07583.1 - 6.2e-07 29.0 19.0 0.093 12.8 0.0 7.8 8 0 0 8 8 8 3 Leucine Rich repeat LRR_9 PF14580.6 ETO07583.1 - 0.006 16.1 4.0 0.047 13.2 0.2 2.8 1 1 0 2 2 2 1 Leucine-rich repeat GxGYxYP_N PF16216.5 ETO07585.1 - 0.024 14.8 0.2 0.062 13.5 0.1 1.7 1 1 0 1 1 1 0 GxGYxY sequence motif in domain of unknown function N-terminal Kelch_2 PF07646.15 ETO07586.1 - 1 9.4 3.1 23 5.1 3.1 2.3 1 1 0 1 1 1 0 Kelch motif DUF2532 PF10811.8 ETO07587.1 - 0.02 14.9 2.7 0.021 14.9 2.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2532) DLH PF01738.18 ETO07589.1 - 3.5e-06 26.7 0.1 5.1e-06 26.2 0.1 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Esterase PF00756.20 ETO07589.1 - 0.0025 17.5 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 Putative esterase Abhydrolase_1 PF00561.20 ETO07589.1 - 0.03 13.9 0.0 0.042 13.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Kelch_1 PF01344.25 ETO07590.1 - 0.00099 18.7 3.0 0.0012 18.4 0.8 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO07590.1 - 0.0021 18.0 0.3 0.047 13.7 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07590.1 - 0.0043 17.0 1.1 0.2 11.7 0.3 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO07590.1 - 0.0047 17.2 2.0 0.39 11.1 0.5 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO07590.1 - 0.054 13.5 5.0 0.32 11.0 2.4 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO07590.1 - 0.13 12.5 0.3 2.9 8.3 0.0 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain WD40 PF00400.32 ETO07592.1 - 2.1e-34 117.0 15.5 1.6e-06 28.7 0.3 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07592.1 - 1.6e-09 38.0 0.3 0.46 10.8 0.0 5.7 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO07592.1 - 1.7e-05 25.4 1.7 1.7e-05 25.4 1.7 2.8 3 0 0 3 3 3 1 TRAF-type zinc finger Nup160 PF11715.8 ETO07592.1 - 2.3e-05 23.2 3.7 1.3 7.5 0.0 4.3 3 2 2 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO07592.1 - 0.0001 22.2 1.9 1 9.2 0.0 3.6 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A BBS2_N PF14781.6 ETO07592.1 - 0.03 14.2 0.1 0.24 11.3 0.0 2.7 3 0 0 3 3 3 0 Ciliary BBSome complex subunit 2, N-terminal DUF4979 PF16351.5 ETO07592.1 - 0.74 10.0 3.1 12 6.1 0.3 3.8 2 2 3 5 5 5 0 Domain of unknown function (DUF4979) 2TM PF13239.6 ETO07594.1 - 0.39 11.1 4.2 0.23 11.8 1.0 2.2 2 0 0 2 2 2 0 2TM domain CARD PF00619.21 ETO07595.1 - 0.078 13.0 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Caspase recruitment domain WD40 PF00400.32 ETO07597.1 - 2.1e-06 28.4 2.0 3.8e-06 27.5 0.6 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat HEAT PF02985.22 ETO07598.1 - 6.8e-10 38.4 0.3 0.22 11.9 0.0 4.6 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 ETO07598.1 - 2.2e-05 24.7 0.0 0.00021 21.6 0.0 2.3 2 1 1 3 3 3 1 HEAT repeats Cnd1 PF12717.7 ETO07598.1 - 0.00015 21.8 9.3 0.13 12.3 4.6 3.2 1 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO07598.1 - 0.012 16.1 0.0 31 5.2 0.0 3.4 4 0 0 4 4 4 0 HEAT-like repeat Colipase-like PF15083.6 ETO07598.1 - 2.9 8.1 10.7 0.35 11.0 4.3 2.4 1 1 0 2 2 2 0 Colipase-like Auts2 PF15336.6 ETO07600.1 - 1.6 8.8 31.2 0.33 11.0 16.6 2.2 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein PI3K_1B_p101 PF10486.9 ETO07600.1 - 5.9 4.5 18.6 6.9 4.3 18.6 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit F-box PF00646.33 ETO07604.1 - 0.00083 19.2 0.4 0.0017 18.2 0.2 1.6 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ETO07604.1 - 0.12 12.2 0.2 0.44 10.5 0.1 1.8 2 0 0 2 2 2 0 F-box-like Exo_endo_phos_2 PF14529.6 ETO07605.1 - 4.2e-17 62.1 4.6 4.2e-17 62.1 4.6 2.6 2 1 1 3 3 3 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO07605.1 - 0.034 13.7 0.0 0.053 13.0 0.0 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family NEMP PF10225.9 ETO07605.1 - 0.45 10.2 1.9 0.96 9.1 1.9 1.5 1 0 0 1 1 1 0 NEMP family Sec62 PF03839.16 ETO07606.1 - 0.81 9.2 2.7 0.88 9.0 2.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO07606.1 - 2 7.1 4.8 2.1 7.0 4.8 1.1 1 0 0 1 1 1 0 Presenilin TPR_2 PF07719.17 ETO07607.1 - 2.9e-05 23.9 15.1 0.055 13.6 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO07607.1 - 8.4e-05 22.8 5.6 0.028 14.7 0.4 3.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07607.1 - 0.0012 18.5 11.1 0.31 10.9 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO07607.1 - 0.0033 18.1 0.1 1.4 10.0 0.0 3.2 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO07607.1 - 0.012 16.3 0.0 9.5 7.0 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO07607.1 - 0.023 15.2 6.6 0.33 11.5 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07607.1 - 0.024 14.3 10.4 0.14 11.9 2.6 3.1 2 1 1 3 3 3 0 TPR repeat TPR_8 PF13181.6 ETO07607.1 - 0.077 13.2 0.7 0.077 13.2 0.7 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat Phage_GPO PF05929.11 ETO07607.1 - 0.58 9.7 11.9 1 8.9 11.9 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FHIPEP PF00771.20 ETO07607.1 - 2.7 6.4 6.5 25 3.1 0.0 2.1 2 0 0 2 2 2 0 FHIPEP family Aminotran_5 PF00266.19 ETO07610.1 - 3.1e-12 46.1 0.2 4.4e-12 45.6 0.2 1.2 1 0 0 1 1 1 1 Aminotransferase class-V Interferon PF00143.19 ETO07610.1 - 0.11 12.7 0.3 0.3 11.3 0.2 1.7 2 0 0 2 2 2 0 Interferon alpha/beta domain ABC_tran PF00005.27 ETO07611.1 - 8.5e-06 26.3 0.0 8.1e-05 23.2 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_5 PF07728.14 ETO07611.1 - 0.00038 20.5 0.0 0.001 19.1 0.0 1.9 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO07611.1 - 0.00062 19.3 0.0 0.0029 17.1 0.0 2.1 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA PF00004.29 ETO07611.1 - 0.0008 19.8 0.0 0.0026 18.2 0.0 2.0 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ETO07611.1 - 0.00084 19.3 0.0 0.0023 17.8 0.0 1.7 1 1 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ETO07611.1 - 0.00087 19.6 0.1 0.016 15.5 0.0 2.5 3 0 0 3 3 3 1 AAA domain ATPase_2 PF01637.18 ETO07611.1 - 0.0023 17.9 0.5 0.07 13.0 0.5 3.0 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea NACHT PF05729.12 ETO07611.1 - 0.005 16.8 0.0 0.26 11.2 0.0 2.6 2 1 0 2 2 2 1 NACHT domain Zeta_toxin PF06414.12 ETO07611.1 - 0.01 15.1 0.0 0.018 14.3 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 ETO07611.1 - 0.013 15.6 0.0 0.044 13.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain Lectin_N PF03954.14 ETO07611.1 - 0.027 14.2 0.0 0.084 12.6 0.0 1.8 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain AAA_16 PF13191.6 ETO07611.1 - 0.04 14.3 0.0 0.066 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 ETO07611.1 - 0.051 14.0 0.1 0.3 11.5 0.0 2.3 2 1 0 2 2 2 0 RNA helicase TsaE PF02367.17 ETO07611.1 - 0.051 13.6 0.2 0.14 12.1 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_21 PF13304.6 ETO07611.1 - 0.07 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Viral_helicase1 PF01443.18 ETO07611.1 - 0.12 12.1 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase PduV-EutP PF10662.9 ETO07611.1 - 0.12 12.1 0.4 0.67 9.7 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_23 PF13476.6 ETO07611.1 - 6.2 7.3 8.0 2.3 8.7 3.8 2.4 2 1 0 2 2 2 0 AAA domain 2OG-FeII_Oxy_2 PF13532.6 ETO07613.1 - 1.1e-12 48.5 0.0 1.4e-12 48.2 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily P30 PF07390.11 ETO07613.1 - 0.019 15.1 0.1 0.036 14.2 0.1 1.5 1 1 0 1 1 1 0 Mycoplasma P30 protein ERAP1_C PF11838.8 ETO07615.1 - 2.1e-30 106.4 0.0 2.8e-30 106.0 0.0 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain WD40 PF00400.32 ETO07616.1 - 1.5e-12 47.8 6.9 3.6e-06 27.6 0.1 5.2 4 0 0 4 4 4 3 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO07616.1 - 0.00045 20.8 5.5 0.00045 20.8 5.5 2.6 3 0 0 3 3 3 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO07616.1 - 0.0061 16.8 0.2 0.35 11.2 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Complex1_LYR PF05347.15 ETO07617.1 - 5.9 7.0 6.4 1 9.5 0.6 2.5 2 0 0 2 2 2 0 Complex 1 protein (LYR family) zf-RING_5 PF14634.6 ETO07618.1 - 0.0022 17.9 5.9 0.0037 17.2 5.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO07618.1 - 0.004 17.0 7.3 0.0075 16.1 7.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO07618.1 - 0.0051 16.8 8.6 0.0099 15.9 8.6 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO07618.1 - 0.089 13.1 7.1 0.15 12.4 7.1 1.4 1 0 0 1 1 1 0 Ring finger domain Prok-RING_4 PF14447.6 ETO07618.1 - 0.1 12.5 7.3 0.21 11.5 7.3 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETO07618.1 - 1.8 8.5 9.5 0.36 10.7 6.0 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-B_box PF00643.24 ETO07618.1 - 9.6 6.5 10.4 0.75 10.0 4.1 2.1 2 0 0 2 2 2 0 B-box zinc finger EamA PF00892.20 ETO07619.1 - 1.8e-06 28.1 14.1 0.00029 21.0 10.7 2.1 2 0 0 2 2 2 2 EamA-like transporter family His_Phos_1 PF00300.22 ETO07620.1 - 2.6e-16 59.9 0.0 1.7e-13 50.7 0.0 2.6 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Piwi PF02171.17 ETO07620.1 - 0.071 12.3 0.1 0.071 12.3 0.1 1.5 2 0 0 2 2 2 0 Piwi domain His_Phos_2 PF00328.22 ETO07620.1 - 0.086 12.2 0.0 0.13 11.6 0.0 1.4 1 1 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) zf-C2H2_4 PF13894.6 ETO07624.1 - 0.0072 17.1 0.2 0.027 15.3 0.2 2.1 1 0 0 1 1 1 1 C2H2-type zinc finger OAD_gamma PF04277.13 ETO07624.1 - 0.023 15.3 3.2 0.041 14.5 0.7 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain zf-H2C2_2 PF13465.6 ETO07624.1 - 0.11 13.0 0.9 8.4 7.0 0.1 2.6 2 0 0 2 2 2 0 Zinc-finger double domain Bac_export_2 PF01312.19 ETO07624.1 - 0.11 11.7 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family zf-LITAF-like PF10601.9 ETO07624.1 - 0.19 12.0 2.9 0.22 11.8 1.2 2.1 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain Roughex PF06020.11 ETO07624.1 - 0.2 10.7 3.6 0.3 10.1 3.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF2681 PF10883.8 ETO07624.1 - 9.6 6.7 11.1 2.8 8.4 2.5 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Connexin PF00029.19 ETO07625.1 - 0.0009 19.1 6.9 0.0049 16.7 5.2 2.1 2 0 0 2 2 2 1 Connexin Disulph_isomer PF06491.11 ETO07625.1 - 0.0051 16.9 0.1 0.015 15.4 0.0 1.8 2 0 0 2 2 2 1 Disulphide isomerase Piwi PF02171.17 ETO07626.1 - 1.9e-37 129.2 3.0 1.3e-36 126.4 2.9 2.1 1 1 0 1 1 1 1 Piwi domain PAZ PF02170.22 ETO07626.1 - 6.2e-09 35.8 0.0 6.2e-09 35.8 0.0 2.7 3 0 0 3 3 3 1 PAZ domain ArgoL2 PF16488.5 ETO07626.1 - 0.069 13.5 0.0 0.23 11.8 0.0 1.9 1 0 0 1 1 1 0 Argonaute linker 2 domain DNA_pol3_a_NII PF11490.8 ETO07626.1 - 2.6 8.0 11.6 0.13 12.2 3.4 2.6 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II ThiJ_like PF17124.5 ETO07627.1 - 3.6e-06 26.8 0.0 6.7e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 ThiJ/PfpI family-like WD40 PF00400.32 ETO07628.1 - 3.4e-09 37.2 4.1 0.00062 20.5 0.3 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ELYS-bb PF16687.5 ETO07628.1 - 0.00046 18.9 0.2 0.48 9.0 0.0 2.1 2 0 0 2 2 2 2 beta-propeller of ELYS nucleoporin BBS2_Mid PF14783.6 ETO07628.1 - 0.013 15.6 0.1 0.12 12.4 0.0 2.5 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DAHP_synth_1 PF00793.20 ETO07628.1 - 0.06 12.2 0.0 0.095 11.5 0.0 1.2 1 0 0 1 1 1 0 DAHP synthetase I family PH_9 PF15410.6 ETO07629.1 - 0.0069 16.7 0.6 4.7 7.6 0.1 2.5 2 0 0 2 2 2 2 Pleckstrin homology domain ThiJ_like PF17124.5 ETO07630.1 - 4.6e-17 62.3 0.0 7.7e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 ThiJ/PfpI family-like FAM176 PF14851.6 ETO07630.1 - 0.0018 17.9 1.9 0.0018 17.9 1.9 2.2 2 0 0 2 2 2 1 FAM176 family CLN3 PF02487.17 ETO07630.1 - 0.0019 17.3 0.8 0.0019 17.3 0.8 2.1 1 1 1 2 2 2 1 CLN3 protein DUF818 PF05677.12 ETO07630.1 - 0.034 13.1 0.0 0.083 11.8 0.0 1.6 1 0 0 1 1 1 0 Chlamydia CHLPS protein (DUF818) DUF4834 PF16118.5 ETO07630.1 - 0.045 14.7 0.1 0.045 14.7 0.1 3.0 3 1 0 3 3 2 0 Domain of unknown function (DUF4834) FHIPEP PF00771.20 ETO07630.1 - 0.062 11.8 0.1 0.088 11.3 0.1 1.2 1 0 0 1 1 1 0 FHIPEP family FAM60A PF15396.6 ETO07630.1 - 0.34 10.9 13.6 0.046 13.7 0.8 2.2 2 0 0 2 2 2 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 ETO07630.1 - 0.72 8.2 6.9 0.28 9.6 4.0 1.6 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 Connexin PF00029.19 ETO07630.1 - 1.8 8.2 12.4 0.026 14.3 2.9 2.1 1 1 1 2 2 2 0 Connexin TRAP_alpha PF03896.16 ETO07630.1 - 3.3 6.8 11.0 0.041 13.1 2.4 1.9 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CemA PF03040.14 ETO07630.1 - 4.7 7.1 10.0 0.16 11.9 3.7 1.7 2 0 0 2 2 2 0 CemA family Tmemb_9 PF05434.11 ETO07630.1 - 5.5 6.9 13.9 0.11 12.4 4.1 2.4 1 1 1 2 2 2 0 TMEM9 DUF4191 PF13829.6 ETO07631.1 - 0.029 13.7 0.1 0.039 13.3 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) Tetraspanin PF00335.20 ETO07631.1 - 1.3 8.7 11.2 3 7.5 11.2 1.6 1 1 0 1 1 1 0 Tetraspanin family Pkinase PF00069.25 ETO07632.1 - 3.1e-41 141.5 3.0 8.2e-20 71.3 0.9 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO07632.1 - 2.1e-19 69.8 4.0 5e-10 39.1 2.2 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase PDDEXK_2 PF12784.7 ETO07633.1 - 7.1e-44 150.1 0.6 8.8e-44 149.7 0.6 1.1 1 0 0 1 1 1 1 PD-(D/E)XK nuclease family transposase Yae1_N PF09811.9 ETO07633.1 - 0.0051 16.5 3.7 0.011 15.5 3.7 1.6 1 0 0 1 1 1 1 Essential protein Yae1, N terminal Ank_4 PF13637.6 ETO07634.1 - 0.00044 20.7 0.1 0.0023 18.5 0.1 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO07634.1 - 0.00072 20.1 0.3 0.0027 18.3 0.3 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO07634.1 - 0.0017 18.7 0.1 2.5 8.7 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETO07634.1 - 0.0028 18.0 0.3 1.6 9.5 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETO07634.1 - 0.023 15.0 0.2 0.26 11.6 0.1 2.2 2 0 0 2 2 2 0 Ankyrin repeats (many copies) PIN_12 PF16289.5 ETO07634.1 - 0.29 11.6 7.5 0.46 11.0 0.3 2.2 2 0 0 2 2 2 0 PIN domain DNA_pol_A_exo1 PF01612.20 ETO07636.1 - 7.5e-20 71.4 0.4 1.4e-19 70.5 0.4 1.5 1 0 0 1 1 1 1 3'-5' exonuclease PMC2NT PF08066.12 ETO07636.1 - 3.5e-11 43.6 0.2 1.4e-10 41.7 0.1 2.1 2 0 0 2 2 2 1 PMC2NT (NUC016) domain WD40 PF00400.32 ETO07637.1 - 7e-39 131.1 20.7 9e-06 26.3 0.2 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07637.1 - 3.3e-10 40.1 2.2 0.43 10.9 0.0 5.1 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07637.1 - 1.8e-09 36.8 6.8 0.00038 19.2 0.1 4.6 3 2 0 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO07637.1 - 0.0041 17.0 1.2 0.36 10.7 0.1 3.5 2 1 0 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ETO07638.1 - 0.0011 19.7 0.3 0.0052 17.6 0.2 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO07639.1 - 2.2e-18 66.2 15.0 5.9e-06 26.9 2.0 4.8 4 0 0 4 4 4 4 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO07639.1 - 6.5e-08 33.1 2.8 6.5e-08 33.1 2.8 3.0 3 1 1 4 4 4 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO07639.1 - 9.8e-06 25.8 0.1 0.077 13.3 0.0 3.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Spc7 PF08317.11 ETO07639.1 - 0.0055 15.6 10.3 0.0088 15.0 10.3 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein V_ATPase_I PF01496.19 ETO07639.1 - 0.012 13.5 4.0 0.017 13.1 4.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_HK97_TLTM PF06120.11 ETO07639.1 - 0.08 12.1 7.0 0.17 11.0 7.0 1.5 1 0 0 1 1 1 0 Tail length tape measure protein FapA PF03961.13 ETO07639.1 - 2.2 6.8 13.6 0.16 10.5 7.9 1.7 2 0 0 2 2 2 0 Flagellar Assembly Protein A tRNA_int_endo PF01974.17 ETO07641.1 - 0.004 17.2 0.0 0.0087 16.1 0.0 1.6 1 0 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain PSII_Pbs27 PF13326.6 ETO07641.1 - 0.16 12.3 2.5 0.21 11.9 0.2 2.0 2 0 0 2 2 2 0 Photosystem II Pbs27 Tubulin PF00091.25 ETO07642.1 - 1.2e-55 188.8 0.0 1.4e-55 188.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO07642.1 - 0.0054 16.0 0.0 0.0073 15.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin like Kelch_6 PF13964.6 ETO07643.1 - 0.001 19.2 0.3 0.033 14.5 0.1 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO07643.1 - 0.044 13.8 0.5 5.6 7.1 0.0 3.4 3 0 0 3 3 3 0 Kelch motif GPR_Gpa2_C PF11970.8 ETO07643.1 - 0.059 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term Kelch_5 PF13854.6 ETO07643.1 - 0.077 13.0 0.3 4.4 7.4 0.0 3.3 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO07643.1 - 0.18 11.4 0.8 13 5.5 0.0 3.4 3 0 0 3 3 3 0 Kelch motif Mpv17_PMP22 PF04117.12 ETO07643.1 - 0.22 11.8 1.3 15 5.9 0.1 2.6 2 0 0 2 2 2 0 Mpv17 / PMP22 family WD40 PF00400.32 ETO07644.1 - 2e-37 126.5 27.2 2e-07 31.6 1.4 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07644.1 - 2.1e-12 47.2 0.5 0.055 13.8 0.0 5.2 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07644.1 - 3.4e-09 35.9 3.8 0.027 13.1 0.2 5.0 2 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07644.1 - 7.3e-05 22.2 9.3 0.39 10.0 0.2 5.1 2 2 4 6 6 6 4 WD40-like domain WD40 PF00400.32 ETO07645.1 - 4e-08 33.8 4.1 0.055 14.4 0.2 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07645.1 - 0.018 15.3 0.1 0.58 10.5 0.1 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07645.1 - 0.048 12.3 0.8 4.2 5.9 0.1 2.4 1 1 2 3 3 3 0 Nucleoporin Nup120/160 ICAM_N PF03921.14 ETO07645.1 - 0.08 12.6 3.0 2.3 8.0 0.1 2.2 1 1 1 2 2 2 0 Intercellular adhesion molecule (ICAM), N-terminal domain POT1 PF02765.17 ETO07645.1 - 0.11 12.4 3.4 0.31 10.9 0.2 2.2 1 1 1 2 2 2 0 Telomeric single stranded DNA binding POT1/CDC13 A_deaminase PF00962.22 ETO07646.1 - 6.5e-15 55.3 0.0 8.1e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 Adenosine/AMP deaminase Kazal_3 PF18434.1 ETO07646.1 - 0.12 12.1 2.9 0.38 10.5 0.3 2.3 2 0 0 2 2 2 0 Kazal-type serine protease inhibitor domain NACHT PF05729.12 ETO07647.1 - 3.4e-11 43.3 0.0 1.4e-10 41.4 0.0 1.8 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO07647.1 - 0.00099 19.5 0.0 0.0015 18.9 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 ETO07647.1 - 0.0012 18.1 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain DUF2075 PF09848.9 ETO07647.1 - 0.0033 16.7 0.1 0.009 15.3 0.0 1.8 1 1 1 2 2 2 1 Uncharacterized conserved protein (DUF2075) Torsin PF06309.11 ETO07647.1 - 0.021 14.9 0.0 0.04 14.0 0.0 1.4 2 0 0 2 2 2 0 Torsin DAP3 PF10236.9 ETO07647.1 - 0.033 13.3 0.0 0.039 13.1 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 ETO07647.1 - 0.037 14.4 0.1 0.055 13.9 0.1 1.3 1 0 0 1 1 1 0 RNA helicase SMC_N PF02463.19 ETO07647.1 - 0.071 12.5 0.0 0.093 12.2 0.0 1.1 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain UPF0180 PF03698.13 ETO07649.1 - 0.004 17.3 0.2 0.0096 16.1 0.2 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0180) FlgM PF04316.13 ETO07649.1 - 0.052 13.9 3.1 1.1 9.7 0.4 2.8 2 0 0 2 2 2 0 Anti-sigma-28 factor, FlgM YflT PF11181.8 ETO07649.1 - 0.19 12.3 3.6 0.29 11.7 0.8 2.4 2 0 0 2 2 2 0 Heat induced stress protein YflT zf-CHY PF05495.12 ETO07649.1 - 2.1 8.9 13.5 0.33 11.5 8.5 2.1 2 0 0 2 2 2 0 CHY zinc finger zf-CCHC PF00098.23 ETO07649.1 - 6.7 7.0 9.0 1.2 9.3 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle FERM_C PF09380.10 ETO07650.1 - 0.0054 17.1 0.2 0.014 15.8 0.2 1.7 1 0 0 1 1 1 1 FERM C-terminal PH-like domain WD40 PF00400.32 ETO07652.1 - 1.5e-28 98.4 10.4 8e-06 26.5 0.3 5.7 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO07652.1 - 2.5e-07 29.7 1.8 0.05 12.2 0.0 3.5 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07652.1 - 4.3e-07 30.1 0.3 0.18 12.1 0.0 4.1 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO07652.1 - 0.014 14.2 2.8 0.34 9.6 0.1 3.3 1 1 2 3 3 3 0 Nup133 N terminal like DUF5046 PF16465.5 ETO07652.1 - 0.045 13.2 0.1 0.091 12.2 0.0 1.6 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) SH3_13 PF18335.1 ETO07652.1 - 0.1 12.4 2.2 2.3 8.1 0.9 3.3 3 1 1 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain RVP PF00077.20 ETO07653.1 - 0.0021 18.4 0.0 0.043 14.1 0.0 2.6 2 0 0 2 2 2 1 Retroviral aspartyl protease gag-asp_proteas PF13975.6 ETO07653.1 - 0.0044 17.5 0.0 0.023 15.2 0.0 2.3 1 1 1 2 2 2 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 ETO07653.1 - 0.0066 16.5 6.3 0.0066 16.5 6.3 2.2 3 0 0 3 3 3 1 Zinc knuckle Asp_protease_2 PF13650.6 ETO07653.1 - 0.15 12.8 0.0 0.34 11.6 0.0 1.6 1 0 0 1 1 1 0 Aspartyl protease PLDc PF00614.22 ETO07656.1 - 3.1e-09 36.6 2.4 0.00048 20.2 0.1 2.8 2 0 0 2 2 2 2 Phospholipase D Active site motif PLDc_2 PF13091.6 ETO07656.1 - 3.8e-08 33.3 5.7 0.00013 21.9 0.1 2.8 3 1 0 3 3 3 2 PLD-like domain DUF1565 PF07602.11 ETO07656.1 - 0.15 11.4 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1565) Ribosomal_L34e PF01199.18 ETO07657.1 - 1.5e-10 41.2 1.0 1.5e-10 41.2 1.0 2.8 2 1 1 3 3 3 1 Ribosomal protein L34e CLN3 PF02487.17 ETO07659.1 - 0.0082 15.2 0.4 0.01 14.9 0.4 1.1 1 0 0 1 1 1 1 CLN3 protein DIE2_ALG10 PF04922.12 ETO07659.1 - 0.81 8.9 2.8 0.47 9.7 0.8 1.6 1 1 1 2 2 2 0 DIE2/ALG10 family MerB PF03243.15 ETO07661.1 - 0.00028 21.0 0.0 0.00057 20.0 0.0 1.4 1 0 0 1 1 1 1 Alkylmercury lyase Clathrin PF00637.20 ETO07662.1 - 7.7e-19 68.0 17.9 8.6e-11 41.9 0.6 2.9 2 1 0 2 2 2 2 Region in Clathrin and VPS VPS11_C PF12451.8 ETO07662.1 - 1.2e-10 41.4 1.4 1.2e-10 41.4 1.4 3.2 4 0 0 4 4 4 1 Vacuolar protein sorting protein 11 C terminal zf-C3H2C3 PF17122.5 ETO07662.1 - 1.4e-05 25.0 8.9 3.5e-05 23.8 8.9 1.7 1 0 0 1 1 1 1 Zinc-finger zf-C3HC4_2 PF13923.6 ETO07662.1 - 0.0018 18.1 10.8 0.0018 18.1 10.8 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO07662.1 - 0.07 13.1 9.3 0.19 11.7 9.3 1.8 1 0 0 1 1 1 0 zinc-RING finger domain ATPgrasp_Ter PF15632.6 ETO07662.1 - 0.076 12.8 0.1 0.19 11.5 0.1 1.7 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon zf-RING_2 PF13639.6 ETO07662.1 - 0.32 11.4 11.6 0.55 10.6 9.7 2.3 2 0 0 2 2 2 0 Ring finger domain zf-rbx1 PF12678.7 ETO07662.1 - 0.43 10.9 7.9 1.3 9.3 7.9 1.9 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETO07662.1 - 0.75 9.9 13.6 0.29 11.2 10.4 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_11 PF17123.5 ETO07662.1 - 0.89 9.4 6.4 3.4 7.5 4.4 2.6 2 0 0 2 2 2 0 RING-like zinc finger DnaG_DnaB_bind PF08278.11 ETO07662.1 - 1.9 9.1 8.6 0.39 11.3 0.2 2.9 3 1 0 3 3 3 0 DNA primase DnaG DnaB-binding DivIC PF04977.15 ETO07662.1 - 3 7.7 11.3 0.64 9.8 5.9 2.5 2 0 0 2 2 2 0 Septum formation initiator zf-C3HC4 PF00097.25 ETO07662.1 - 6 6.8 13.3 5.1 7.0 10.9 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) BST2 PF16716.5 ETO07662.1 - 9.7 6.9 11.2 5.5 7.6 0.9 2.7 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Ge1_WD40 PF16529.5 ETO07663.1 - 0.021 13.8 0.0 0.053 12.5 0.0 1.6 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein ETRAMP PF09716.10 ETO07664.1 - 0.042 13.9 0.2 7 6.8 0.0 3.5 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) MutS_V PF00488.21 ETO07665.1 - 1.8e-71 240.1 0.4 3.1e-71 239.3 0.4 1.3 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETO07665.1 - 7e-33 114.5 2.3 7e-33 114.5 2.3 2.4 2 1 0 2 2 2 1 MutS domain III MutS_I PF01624.20 ETO07665.1 - 7.4e-18 64.8 0.1 2.3e-17 63.2 0.0 1.8 1 1 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ETO07665.1 - 3.7e-09 37.0 0.0 3.7e-09 37.0 0.0 3.0 3 0 0 3 3 3 1 MutS domain II MutS_IV PF05190.18 ETO07665.1 - 2.5e-05 24.5 5.9 2.5e-05 24.5 5.9 2.5 2 0 0 2 2 2 1 MutS family domain IV ORC6 PF05460.13 ETO07665.1 - 0.33 10.2 21.5 0.72 9.1 21.5 1.5 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Kelch_4 PF13418.6 ETO07666.1 - 9.9e-07 28.7 0.1 0.0085 16.1 0.0 2.7 2 1 1 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO07666.1 - 4.5e-06 26.4 0.5 0.00019 21.2 0.2 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO07666.1 - 4.7e-06 26.1 1.6 0.0003 20.3 1.0 2.4 2 0 0 2 2 2 2 Kelch motif PTR2 PF00854.21 ETO07667.1 - 7.6e-27 94.2 0.5 8.9e-27 93.9 0.5 1.0 1 0 0 1 1 1 1 POT family Surp PF01805.20 ETO07670.1 - 0.1 12.6 0.2 0.2 11.7 0.2 1.4 1 0 0 1 1 1 0 Surp module PDGF PF00341.17 ETO07671.1 - 0.0075 16.5 4.0 0.013 15.8 4.0 1.4 1 0 0 1 1 1 1 PDGF/VEGF domain Mad3_BUB1_I_2 PF17014.5 ETO07671.1 - 0.13 12.3 3.8 1.7 8.8 4.4 2.0 1 1 0 1 1 1 0 Putative Mad3/BUB1 like region 1 protein Utp14 PF04615.13 ETO07673.1 - 0.053 12.1 13.5 0.079 11.5 13.5 1.2 1 0 0 1 1 1 0 Utp14 protein KicB PF03882.14 ETO07673.1 - 0.21 11.8 0.2 0.21 11.8 0.2 2.5 2 0 0 2 2 2 0 MukF winged-helix domain WD40 PF00400.32 ETO07674.1 - 2.4e-14 53.5 4.2 2.4e-08 34.5 0.3 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO07674.1 - 4.1e-05 23.0 1.2 4.1e-05 23.0 1.2 1.6 2 0 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO07674.1 - 0.00059 18.6 1.1 0.00078 18.2 1.1 1.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07674.1 - 0.015 15.6 0.0 0.035 14.4 0.0 1.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain SRI PF08236.11 ETO07676.1 - 0.016 15.3 0.1 0.029 14.5 0.1 1.5 1 0 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain FRB_dom PF08771.11 ETO07676.1 - 0.028 14.8 0.3 0.92 10.0 0.1 2.2 2 0 0 2 2 2 0 FKBP12-rapamycin binding domain bVLRF1 PF18826.1 ETO07676.1 - 0.1 12.5 1.5 1.3 8.8 0.2 2.2 2 0 0 2 2 2 0 bacteroidetes VLRF1 release factor SesA PF17107.5 ETO07676.1 - 0.2 11.9 3.8 1.8 8.8 2.8 2.2 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF1359 PF07097.11 ETO07677.1 - 0.87 9.9 9.1 2.2 8.6 0.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1359) CAP_GLY PF01302.25 ETO07678.1 - 7.7e-05 22.6 0.0 0.00024 21.1 0.0 1.8 2 0 0 2 2 2 1 CAP-Gly domain GRP PF07172.11 ETO07678.1 - 0.077 13.7 0.5 0.49 11.1 0.2 2.1 2 0 0 2 2 2 0 Glycine rich protein family Amidohydro_3 PF07969.11 ETO07679.1 - 0.019 14.5 0.0 0.03 13.8 0.0 1.4 2 0 0 2 2 2 0 Amidohydrolase family TraU PF06834.11 ETO07680.1 - 0.045 13.0 0.2 0.07 12.4 0.2 1.2 1 0 0 1 1 1 0 TraU protein Glyco_hydro_47 PF01532.20 ETO07681.1 - 1.5e-27 96.6 0.0 1.7e-27 96.5 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 MukE PF04288.13 ETO07682.1 - 1.6 7.6 4.1 0.37 9.7 0.1 2.0 2 0 0 2 2 2 0 MukE-like family Amidohydro_1 PF01979.20 ETO07683.1 - 2.4e-13 50.1 0.0 1.5e-10 40.9 0.0 2.4 2 1 0 2 2 2 2 Amidohydrolase family Amidohydro_3 PF07969.11 ETO07683.1 - 3.3e-12 46.6 0.0 3.6e-08 33.3 0.0 2.2 2 0 0 2 2 2 2 Amidohydrolase family TLD PF07534.16 ETO07684.1 - 5.5e-05 23.4 1.4 0.00015 22.0 0.0 2.4 2 0 0 2 2 2 1 TLD Colicin_im PF03857.13 ETO07684.1 - 0.01 15.8 0.1 0.022 14.7 0.1 1.5 1 0 0 1 1 1 0 Colicin immunity protein DUF1247 PF06851.11 ETO07685.1 - 0.055 13.4 0.4 0.22 11.4 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1247) Innexin PF00876.18 ETO07689.1 - 0.002 17.5 0.2 0.0023 17.3 0.2 1.2 1 0 0 1 1 1 1 Innexin SID-1_RNA_chan PF13965.6 ETO07689.1 - 0.025 13.0 1.7 0.029 12.8 1.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Chromo PF00385.24 ETO07690.1 - 4.4e-14 52.1 5.7 4.5e-07 29.7 0.1 2.8 2 1 1 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain SRR1 PF07985.12 ETO07690.1 - 0.024 14.7 0.0 10 6.2 0.0 2.5 2 0 0 2 2 2 0 SRR1 SNF2_N PF00176.23 ETO07691.1 - 3.3e-40 137.9 0.1 5.7e-40 137.1 0.1 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO07691.1 - 1.6e-08 34.7 0.1 5.5e-07 29.7 0.0 2.6 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO07691.1 - 7e-05 22.7 0.0 0.00028 20.7 0.0 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO07691.1 - 0.00054 20.2 0.1 0.0022 18.2 0.0 2.1 2 1 1 3 3 3 1 AAA domain SWI2_SNF2 PF18766.1 ETO07691.1 - 0.0098 15.6 0.0 0.026 14.2 0.0 1.6 2 0 0 2 2 2 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 ETO07691.1 - 0.026 13.8 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Cyclin_N PF00134.23 ETO07692.1 - 0.0025 17.6 0.3 1.8 8.3 0.2 2.3 2 0 0 2 2 2 2 Cyclin, N-terminal domain TMEM154 PF15102.6 ETO07693.1 - 0.0012 18.8 0.5 0.0042 17.0 0.0 2.0 2 0 0 2 2 2 1 TMEM154 protein family Peptidase_M56 PF05569.11 ETO07693.1 - 0.0042 16.3 0.0 0.0063 15.7 0.0 1.3 1 0 0 1 1 1 1 BlaR1 peptidase M56 Vpu PF00558.19 ETO07693.1 - 0.0069 16.1 0.1 0.014 15.1 0.1 1.5 1 0 0 1 1 1 1 Vpu protein TMEM51 PF15345.6 ETO07693.1 - 0.0086 15.9 0.3 0.021 14.7 0.3 1.4 1 1 0 1 1 1 1 Transmembrane protein 51 Miga PF10265.9 ETO07693.1 - 0.013 14.5 2.3 0.019 13.9 2.3 1.1 1 0 0 1 1 1 0 Mitoguardin SpoIIIAH PF12685.7 ETO07693.1 - 0.037 13.9 0.3 0.059 13.2 0.3 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Amnionless PF14828.6 ETO07693.1 - 0.046 12.6 0.1 0.06 12.2 0.1 1.2 1 0 0 1 1 1 0 Amnionless Phage_holin_2_4 PF16082.5 ETO07693.1 - 0.098 12.4 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Orf78 PF06024.12 ETO07693.1 - 0.11 12.8 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Orf78 (ac78) MLANA PF14991.6 ETO07693.1 - 0.16 12.3 0.1 0.33 11.2 0.1 1.5 1 1 0 1 1 1 0 Protein melan-A WD40 PF00400.32 ETO07694.1 - 1.2e-43 146.3 26.6 1.2e-06 29.1 0.7 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07694.1 - 3.9e-13 49.5 2.2 0.021 15.1 0.0 6.3 4 3 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO07694.1 - 2.4e-07 31.4 2.3 1e-06 29.3 2.3 2.2 1 0 0 1 1 1 1 TRAF-type zinc finger Zip PF02535.22 ETO07694.1 - 0.86 8.8 8.3 1.6 7.9 8.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter YjcZ PF13990.6 ETO07694.1 - 4 6.7 8.9 6.6 6.0 8.9 1.2 1 0 0 1 1 1 0 YjcZ-like protein Presenilin PF01080.17 ETO07694.1 - 9.4 4.9 10.0 16 4.1 10.0 1.4 1 0 0 1 1 1 0 Presenilin TMEM215 PF15746.5 ETO07694.1 - 9.9 5.6 7.9 19 4.6 7.9 1.4 1 0 0 1 1 1 0 TMEM215 family Peptidase_C14 PF00656.22 ETO07695.1 - 6.4e-06 26.3 2.7 0.00025 21.1 0.1 2.5 2 1 1 3 3 3 2 Caspase domain NDUF_B5 PF09781.9 ETO07695.1 - 0.0046 16.6 0.1 0.0093 15.6 0.1 1.4 1 0 0 1 1 1 1 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit RIO1 PF01163.22 ETO07695.1 - 0.049 13.2 0.5 0.24 11.0 0.1 2.1 1 1 1 2 2 2 0 RIO1 family DBR1 PF05011.13 ETO07696.1 - 0.017 15.6 2.9 0.58 10.6 0.2 2.3 2 0 0 2 2 2 0 Lariat debranching enzyme, C-terminal domain RSN1_TM PF13967.6 ETO07696.1 - 0.041 13.6 0.2 0.12 12.2 0.2 1.9 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport YmaF PF12788.7 ETO07696.1 - 0.074 13.6 2.1 0.19 12.3 2.1 1.7 1 0 0 1 1 1 0 YmaF family Lipoprotein_20 PF13942.6 ETO07697.1 - 0.2 11.6 7.6 0.33 10.8 4.9 2.2 2 0 0 2 2 2 0 YfhG lipoprotein LAP1C PF05609.12 ETO07697.1 - 1.4 7.9 14.5 2.4 7.2 14.5 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ycf70 PF17382.2 ETO07697.1 - 2 8.8 5.8 4.2 7.9 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized Ycf70-like GRP PF07172.11 ETO07698.1 - 0.16 12.6 0.7 0.3 11.8 0.7 1.3 1 0 0 1 1 1 0 Glycine rich protein family RVT_1 PF00078.27 ETO07699.1 - 1.5e-37 129.3 0.2 1.5e-37 129.3 0.2 1.8 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 ETO07699.1 - 4.7e-11 42.6 1.2 9.6e-11 41.6 0.1 2.2 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO07699.1 - 0.0029 17.2 0.0 0.0045 16.5 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF573 PF04504.14 ETO07699.1 - 0.0038 17.9 0.6 0.0038 17.9 0.6 2.8 4 0 0 4 4 4 1 Protein of unknown function, DUF573 PUB PF09409.10 ETO07700.1 - 0.0024 17.8 1.0 0.0024 17.8 1.0 2.4 3 1 0 3 3 3 1 PUB domain Dymeclin PF09742.9 ETO07700.1 - 0.016 13.7 0.1 0.019 13.4 0.1 1.1 1 0 0 1 1 1 0 Dyggve-Melchior-Clausen syndrome protein CemA PF03040.14 ETO07700.1 - 0.049 13.6 0.3 0.078 12.9 0.3 1.3 1 0 0 1 1 1 0 CemA family DUF1002 PF06207.11 ETO07700.1 - 0.089 12.3 0.9 0.13 11.8 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) UL45 PF05473.12 ETO07700.1 - 0.13 11.9 0.1 0.18 11.4 0.1 1.2 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like NCKAP5 PF15246.6 ETO07701.1 - 0.71 9.4 15.2 1 8.9 15.2 1.2 1 0 0 1 1 1 0 Nck-associated protein 5, Peripheral clock protein DUF4158 PF13700.6 ETO07702.1 - 0.11 12.3 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) OAD_gamma PF04277.13 ETO07702.1 - 0.14 12.7 0.6 1.1 9.9 0.0 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain LAGLIDADG_1 PF00961.19 ETO07702.1 - 0.5 11.4 5.1 1.1 10.3 5.1 1.6 1 0 0 1 1 1 0 LAGLIDADG endonuclease MMR_HSR1 PF01926.23 ETO07703.1 - 2.7e-18 66.1 0.1 1.9e-17 63.4 0.0 2.4 1 1 1 2 2 2 1 50S ribosome-binding GTPase KH_dom-like PF14714.6 ETO07703.1 - 3.1e-18 65.9 2.4 8.8e-18 64.4 2.4 1.9 1 0 0 1 1 1 1 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal FeoB_N PF02421.18 ETO07703.1 - 2.9e-09 36.6 0.0 2.6e-05 23.8 0.0 2.6 2 1 0 2 2 2 2 Ferrous iron transport protein B GTP_EFTU PF00009.27 ETO07703.1 - 9.2e-07 28.6 0.9 0.00027 20.5 0.1 3.5 4 0 0 4 4 4 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ETO07703.1 - 0.00081 19.5 0.0 0.00081 19.5 0.0 3.7 3 1 0 3 3 3 1 Dynamin family RsgA_GTPase PF03193.16 ETO07703.1 - 0.0032 17.4 0.4 0.89 9.4 0.0 2.9 2 0 0 2 2 2 1 RsgA GTPase Ras PF00071.22 ETO07703.1 - 0.011 15.4 0.0 2.1 7.9 0.0 2.8 2 1 0 2 2 2 0 Ras family SMG1 PF15785.5 ETO07703.1 - 0.032 12.6 3.6 0.61 8.4 1.1 2.3 2 0 0 2 2 2 0 Serine/threonine-protein kinase smg-1 MeaB PF03308.16 ETO07703.1 - 0.17 10.8 0.0 1.1 8.2 0.0 2.1 2 0 0 2 2 2 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Presenilin PF01080.17 ETO07703.1 - 6.6 5.4 9.1 13 4.4 9.1 1.4 1 0 0 1 1 1 0 Presenilin VWA_2 PF13519.6 ETO07704.1 - 4.5e-07 30.5 0.1 8.3e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF5578 PF17741.1 ETO07704.1 - 0.042 13.3 0.0 2.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5578) HSP90 PF00183.18 ETO07705.1 - 2.6e-85 287.3 22.4 4.8e-82 276.5 13.1 2.0 1 1 1 2 2 2 2 Hsp90 protein Kinesin PF00225.23 ETO07708.1 - 6.5e-54 183.1 2.4 6.5e-54 183.1 2.4 1.6 2 0 0 2 2 2 1 Kinesin motor domain Effector_1 PF04518.12 ETO07708.1 - 2.5e-05 23.6 0.8 4e-05 22.9 0.8 1.4 1 0 0 1 1 1 1 Effector from type III secretion system EF-hand_1 PF00036.32 ETO07708.1 - 0.0019 17.6 1.8 0.0025 17.3 0.3 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO07708.1 - 0.0028 17.5 0.4 0.014 15.3 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain EzrA PF06160.12 ETO07708.1 - 0.0047 15.2 5.8 0.0093 14.2 5.8 1.4 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA EF-hand_7 PF13499.6 ETO07708.1 - 0.018 15.5 0.7 0.069 13.6 0.1 2.3 3 0 0 3 3 3 0 EF-hand domain pair Kinesin_assoc PF16183.5 ETO07708.1 - 0.049 13.8 3.9 1.1 9.4 1.6 2.9 1 1 2 3 3 3 0 Kinesin-associated Mod_r PF07200.13 ETO07708.1 - 0.066 13.3 8.7 0.45 10.6 5.9 2.6 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein EAP30 PF04157.16 ETO07708.1 - 0.12 11.6 3.8 0.28 10.4 0.6 2.2 1 1 1 2 2 2 0 EAP30/Vps36 family COG5 PF10392.9 ETO07708.1 - 0.29 11.3 7.2 0.13 12.5 4.2 1.9 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF1664 PF07889.12 ETO07708.1 - 0.94 9.5 6.5 6.4 6.8 6.5 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ETO07708.1 - 2.6 8.2 8.2 8.5 6.6 8.2 1.9 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family HAUS-augmin3 PF14932.6 ETO07708.1 - 3.8 7.0 11.3 0.08 12.5 3.9 2.0 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 3 Peptidase_M1_N PF17900.1 ETO07709.1 - 2.5e-05 24.5 0.4 2.9e-05 24.3 0.4 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain RNA_bind PF08675.11 ETO07709.1 - 0.014 15.4 0.0 0.018 15.0 0.0 1.3 1 0 0 1 1 1 0 RNA binding domain SepSecS PF05889.13 ETO07712.1 - 4.7e-82 275.8 0.6 6.2e-82 275.4 0.6 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Peroxin-13_N PF04088.13 ETO07712.1 - 0.3 11.4 2.3 0.51 10.6 2.3 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF3276 PF11680.8 ETO07712.1 - 0.69 10.0 11.3 1.2 9.3 11.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) WD40 PF00400.32 ETO07713.1 - 3.8e-20 71.8 9.5 1.2e-05 26.0 0.0 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07713.1 - 3.8e-07 30.3 1.9 0.012 15.9 0.0 4.1 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07713.1 - 1.2e-05 24.2 6.8 0.091 11.4 0.0 3.6 1 1 2 3 3 3 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO07713.1 - 0.00032 21.3 0.4 0.00032 21.3 0.4 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger HIP1_clath_bdg PF16515.5 ETO07713.1 - 2.2 8.9 8.3 1.7 9.3 6.0 1.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NACHT PF05729.12 ETO07714.1 - 3.4e-11 43.3 0.0 4.9e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO07714.1 - 1.7e-05 25.1 0.1 4.5e-05 23.7 0.1 1.7 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO07714.1 - 4.6e-05 24.0 0.6 0.00011 22.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETO07714.1 - 0.0034 17.3 1.2 0.031 14.2 0.1 2.4 1 1 1 3 3 3 1 RsgA GTPase TsaE PF02367.17 ETO07714.1 - 0.0055 16.7 0.0 0.018 15.0 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 ETO07714.1 - 0.0061 16.3 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ETO07714.1 - 0.014 15.8 0.3 0.25 11.7 0.1 2.3 1 1 1 3 3 3 0 AAA ATPase domain RNA_helicase PF00910.22 ETO07714.1 - 0.015 15.7 0.1 0.068 13.6 0.1 2.2 1 1 1 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO07714.1 - 0.022 15.3 0.3 0.037 14.5 0.2 1.4 1 1 0 1 1 1 0 ABC transporter AAA_5 PF07728.14 ETO07714.1 - 0.022 14.7 0.0 0.041 13.9 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO07714.1 - 0.025 15.0 0.0 0.043 14.2 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ETO07714.1 - 0.034 13.4 0.0 0.059 12.6 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin DUF2599 PF10783.9 ETO07714.1 - 0.04 14.6 0.2 0.092 13.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2599) DAP3 PF10236.9 ETO07714.1 - 0.053 12.7 0.3 0.34 10.0 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.6 ETO07714.1 - 0.056 13.2 0.1 0.1 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO07714.1 - 0.081 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ETO07714.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 ETO07714.1 - 0.23 11.0 0.0 22 4.5 0.0 2.4 2 1 0 2 2 2 0 AAA domain EF-hand_1 PF00036.32 ETO07714.1 - 0.6 9.8 3.4 0.33 10.6 0.9 2.0 2 0 0 2 2 2 0 EF hand Ammonium_transp PF00909.21 ETO07715.1 - 1.7e-53 181.8 9.3 2e-53 181.5 9.3 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF5316 PF17247.2 ETO07715.1 - 0.0016 18.4 2.4 0.0098 15.9 0.3 3.3 1 1 1 2 2 2 1 Family of unknown function (DUF5316) CPP1-like PF11833.8 ETO07715.1 - 0.19 11.4 1.6 4.4 6.9 0.1 3.0 2 1 1 3 3 3 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Orf78 PF06024.12 ETO07720.1 - 0.27 11.6 3.7 9.9 6.5 2.3 2.7 2 1 1 3 3 3 0 Orf78 (ac78) Ribosomal_L30_N PF08079.12 ETO07721.1 - 0.015 15.5 2.5 0.028 14.7 2.5 1.4 1 0 0 1 1 1 0 Ribosomal L30 N-terminal domain DUF3139 PF11337.8 ETO07722.1 - 0.052 14.2 0.8 0.11 13.1 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) HIRAN PF08797.11 ETO07723.1 - 0.019 14.9 0.0 0.037 14.0 0.0 1.5 1 0 0 1 1 1 0 HIRAN domain Beta_helix PF13229.6 ETO07724.1 - 9.1e-07 28.9 9.6 9.1e-07 28.9 9.6 3.0 2 2 0 2 2 2 1 Right handed beta helix region DUF1565 PF07602.11 ETO07724.1 - 0.0017 17.7 1.1 0.003 17.0 1.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1565) SnoaL_4 PF13577.6 ETO07726.1 - 9.9e-16 58.0 0.0 1.3e-15 57.7 0.0 1.0 1 0 0 1 1 1 1 SnoaL-like domain SnoaL_2 PF12680.7 ETO07726.1 - 0.0018 18.9 0.0 0.0028 18.3 0.0 1.4 1 1 0 1 1 1 1 SnoaL-like domain NTF2 PF02136.20 ETO07726.1 - 0.08 13.5 0.0 0.11 13.0 0.0 1.3 1 1 0 1 1 1 0 Nuclear transport factor 2 (NTF2) domain Spc24 PF08286.11 ETO07727.1 - 0.00018 21.7 3.5 0.021 15.1 0.4 2.7 2 0 0 2 2 2 2 Spc24 subunit of Ndc80 SAM_KSR1 PF13543.6 ETO07727.1 - 0.12 12.5 3.8 0.14 12.3 0.8 2.4 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 SKA2 PF16740.5 ETO07727.1 - 0.89 9.4 4.8 0.36 10.6 0.8 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 WD40 PF00400.32 ETO07728.1 - 6.4e-47 156.6 17.8 4.5e-09 36.8 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07728.1 - 4.4e-17 62.2 6.3 0.0031 17.8 0.0 6.7 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07728.1 - 4.1e-12 45.7 0.8 0.021 13.8 0.0 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO07728.1 - 1.8e-10 40.7 6.9 9e-06 25.2 0.1 3.5 2 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO07728.1 - 3.8e-08 32.4 5.9 0.21 10.2 0.4 4.5 2 1 1 4 4 4 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO07728.1 - 0.00019 21.4 5.9 0.21 11.7 0.2 4.2 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 ETO07728.1 - 0.00051 19.9 0.1 8.2 6.5 0.0 3.8 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO07728.1 - 0.0032 16.3 0.2 2.1 7.0 0.0 3.4 1 1 2 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Str_synth PF03088.16 ETO07728.1 - 0.037 14.2 0.1 6.3 7.0 0.0 3.2 4 0 0 4 4 4 0 Strictosidine synthase PQQ PF01011.21 ETO07728.1 - 0.085 12.8 0.0 87 3.3 0.0 3.9 3 0 0 3 3 3 0 PQQ enzyme repeat DUF5570 PF17731.1 ETO07728.1 - 0.23 11.6 1.3 35 4.5 0.0 3.5 2 1 1 4 4 4 0 Family of unknown function (DUF5570) DUF3088 PF11287.8 ETO07731.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3088) Peptidase_C78 PF07910.13 ETO07732.1 - 4.1e-05 23.2 1.3 6.3e-05 22.6 0.2 1.8 2 0 0 2 2 2 1 Peptidase family C78 RicinB_lectin_2 PF14200.6 ETO07732.1 - 0.0071 17.1 3.2 0.088 13.5 0.3 2.9 1 1 2 3 3 3 1 Ricin-type beta-trefoil lectin domain-like HEAT PF02985.22 ETO07733.1 - 1.3e-07 31.3 0.0 8.1 7.0 0.0 8.3 10 0 0 10 10 9 1 HEAT repeat HEAT_2 PF13646.6 ETO07733.1 - 4.2e-07 30.3 0.0 0.22 12.0 0.0 4.6 4 1 1 5 5 5 2 HEAT repeats Ank_3 PF13606.6 ETO07733.1 - 2.2e-06 27.6 0.2 0.0015 18.9 0.0 4.1 3 0 0 3 3 3 1 Ankyrin repeat RTP1_C1 PF10363.9 ETO07733.1 - 3.7e-06 27.1 10.3 0.59 10.3 0.0 5.9 4 2 2 6 6 6 3 Required for nuclear transport of RNA pol II C-terminus 1 Ank_4 PF13637.6 ETO07733.1 - 1.4e-05 25.5 2.4 3.3e-05 24.4 0.5 2.9 2 0 0 2 2 1 1 Ankyrin repeats (many copies) Cnd1 PF12717.7 ETO07733.1 - 1.6e-05 25.0 30.1 0.0057 16.7 1.6 5.3 2 1 2 4 4 4 3 non-SMC mitotic condensation complex subunit 1 Ank_2 PF12796.7 ETO07733.1 - 2.1e-05 25.0 3.2 9.3e-05 22.9 0.1 3.6 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO07733.1 - 8.2e-05 22.8 0.7 0.0041 17.4 0.1 2.8 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO07733.1 - 0.005 17.2 0.0 0.046 14.2 0.0 2.8 1 0 0 1 1 1 1 Ankyrin repeat DUF1160 PF06648.11 ETO07733.1 - 0.9 9.5 24.8 0.33 10.9 0.5 6.3 5 2 2 7 7 7 0 Protein of unknown function (DUF1160) DUF3361 PF11841.8 ETO07733.1 - 0.95 9.4 16.6 1.1 9.2 0.2 4.7 4 3 0 4 4 4 0 Domain of unknown function (DUF3361) P16-Arc PF04699.14 ETO07733.1 - 1.5 9.3 6.0 34 4.9 0.3 4.0 2 1 1 3 3 3 0 ARP2/3 complex 16 kDa subunit (p16-Arc) Vac14_Fab1_bd PF12755.7 ETO07733.1 - 2.8 8.6 23.3 0.71 10.5 0.4 7.0 4 2 3 7 7 7 0 Vacuolar 14 Fab1-binding region Peptidase_C1 PF00112.23 ETO07734.1 - 3.7e-25 89.3 0.8 4.1e-25 89.2 0.8 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ETO07734.1 - 0.022 13.6 1.1 0.029 13.2 1.1 1.1 1 0 0 1 1 1 0 Peptidase C1-like family Peptidase_C1 PF00112.23 ETO07735.1 - 4.2e-14 53.2 4.6 2.1e-06 28.0 0.0 2.6 2 1 0 2 2 2 2 Papain family cysteine protease WD40 PF00400.32 ETO07736.1 - 2.7e-06 28.0 0.6 0.00067 20.4 0.2 2.7 2 2 0 2 2 2 2 WD domain, G-beta repeat SprB PF13573.6 ETO07736.1 - 0.61 9.9 4.5 7.5 6.4 0.1 2.4 2 0 0 2 2 2 0 SprB repeat AIG1 PF04548.16 ETO07737.1 - 4.6e-12 45.7 0.0 6.5e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 AIG1 family AAA PF00004.29 ETO07737.1 - 0.11 12.9 0.0 15 6.0 0.0 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) P_proprotein PF01483.20 ETO07737.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Proprotein convertase P-domain Kelch_5 PF13854.6 ETO07738.1 - 0.024 14.6 0.1 12 6.0 0.0 3.0 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO07739.1 - 1.4e-38 130.1 8.0 2.6e-09 37.6 0.1 6.3 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07739.1 - 3.1e-16 59.4 0.1 0.0039 17.5 0.1 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07739.1 - 3.4e-05 23.0 1.4 0.14 11.1 0.1 3.7 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO07739.1 - 5.8e-05 21.9 0.4 0.025 13.2 0.0 2.7 2 1 0 2 2 2 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO07739.1 - 0.0001 22.1 2.4 9.3 6.3 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO07739.1 - 0.028 12.9 0.1 5.3 5.5 0.0 2.4 1 1 2 3 3 3 0 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO07739.1 - 0.047 13.0 0.2 13 5.0 0.0 3.3 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO07739.1 - 1.3 8.8 6.4 13 5.6 0.1 3.7 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Pyr_redox_2 PF07992.14 ETO07740.1 - 3.2e-10 39.7 0.0 4e-10 39.4 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO07740.1 - 0.0011 19.5 0.1 0.032 14.8 0.1 2.9 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase DASH_Ask1 PF08655.10 ETO07740.1 - 0.058 13.3 0.6 0.23 11.4 0.4 2.0 1 1 1 2 2 2 0 DASH complex subunit Ask1 WD40 PF00400.32 ETO07741.1 - 1.5e-27 95.3 16.7 2.4e-07 31.3 1.1 7.1 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO07741.1 - 8.3e-11 41.2 7.7 0.00011 21.0 1.4 4.7 3 2 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07741.1 - 1.2e-08 35.1 0.1 0.02 15.2 0.0 5.1 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO07741.1 - 2.2e-08 34.7 1.5 1.3e-07 32.2 1.5 2.4 1 0 0 1 1 1 1 TRAF-type zinc finger Cytochrom_D1 PF02239.16 ETO07741.1 - 0.043 12.3 0.2 0.59 8.6 0.1 2.3 3 0 0 3 3 3 0 Cytochrome D1 heme domain Exonuc_VII_L PF02601.15 ETO07741.1 - 0.82 9.2 5.3 1.2 8.6 5.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-C3HC4_4 PF15227.6 ETO07741.1 - 2.9 8.1 5.6 10 6.3 0.5 3.1 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING WD40 PF00400.32 ETO07742.1 - 2e-82 268.9 44.9 3.5e-08 34.0 0.1 14.8 16 0 0 16 16 15 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07742.1 - 1.3e-24 86.3 18.6 0.0089 16.3 0.0 11.1 1 1 7 10 10 10 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07742.1 - 4.1e-19 68.7 7.0 0.18 10.7 0.0 10.9 2 2 9 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO07742.1 - 9.1e-10 38.7 0.0 2.4e-09 37.3 0.0 1.8 2 0 0 2 2 2 1 NACHT domain PD40 PF07676.12 ETO07742.1 - 2.6e-09 36.8 11.3 1.5 8.9 0.0 9.5 11 0 0 11 11 11 3 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO07742.1 - 1.2e-08 34.5 2.4 2.8e-08 33.2 2.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO07742.1 - 0.00028 21.0 1.2 0.00078 19.6 1.2 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO07742.1 - 0.0015 19.1 0.0 0.0065 17.0 0.0 2.2 1 0 0 1 1 1 1 AAA domain DUF5570 PF17731.1 ETO07742.1 - 0.006 16.7 9.2 9.7 6.3 0.1 5.5 4 2 2 6 6 5 1 Family of unknown function (DUF5570) AAA_22 PF13401.6 ETO07742.1 - 0.007 16.7 0.0 0.019 15.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain Pentapeptide_3 PF13576.6 ETO07742.1 - 0.0082 16.3 0.7 0.02 15.0 0.7 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5319 PF17252.2 ETO07742.1 - 0.021 15.0 0.0 41 4.4 0.0 4.5 2 1 2 4 4 4 0 Family of unknown function (DUF5319) AAA_29 PF13555.6 ETO07742.1 - 0.069 12.9 0.1 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO07742.1 - 0.073 13.6 0.1 1.4 9.4 0.0 3.0 3 0 0 3 3 2 0 ABC transporter OTOS PF15182.6 ETO07742.1 - 0.77 9.7 3.4 2.3 8.2 0.3 3.0 2 0 0 2 2 2 0 Otospiralin Syndecan PF01034.20 ETO07743.1 - 0.094 12.6 2.6 9.2 6.3 0.3 2.9 2 0 0 2 2 2 0 Syndecan domain DUF2236 PF09995.9 ETO07744.1 - 1.2e-15 58.4 0.0 1.5e-15 58.0 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) RGS PF00615.19 ETO07745.1 - 3.1e-06 27.5 1.3 6.9e-06 26.3 1.3 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF2791 PF10923.8 ETO07745.1 - 0.16 10.8 0.0 0.24 10.2 0.0 1.2 1 0 0 1 1 1 0 P-loop Domain of unknown function (DUF2791) HNH_repeat PF18780.1 ETO07745.1 - 6.1 6.7 5.9 11 5.9 5.9 1.5 1 0 0 1 1 1 0 Homing endonuclease repeat WD40 PF00400.32 ETO07746.1 - 1.1e-34 117.9 26.0 4.2e-06 27.4 0.3 7.5 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO07746.1 - 1.9e-13 49.9 6.0 0.081 11.6 0.2 5.8 2 2 4 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07746.1 - 1.9e-08 34.5 1.1 0.83 10.0 0.0 5.4 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07746.1 - 0.00021 20.7 2.4 0.25 10.6 0.2 4.0 2 2 2 4 4 4 2 WD40-like domain Nucleoporin_N PF08801.11 ETO07746.1 - 0.0066 15.2 3.9 1.2 7.8 0.8 3.7 3 1 0 4 4 4 2 Nup133 N terminal like SAM_2 PF07647.17 ETO07747.1 - 0.061 13.4 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF1168 PF06658.12 ETO07747.1 - 1.1 9.0 12.6 2.1 8.2 12.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) CUB PF00431.20 ETO07748.1 - 0.12 12.7 3.9 0.16 12.3 1.5 2.0 1 1 0 2 2 2 0 CUB domain Soc PF16855.5 ETO07749.1 - 0.02 15.3 0.8 0.064 13.7 0.6 1.9 1 1 0 1 1 1 0 Small outer capsid protein PBD PF00786.28 ETO07749.1 - 0.17 12.3 0.2 0.38 11.1 0.2 1.6 1 0 0 1 1 1 0 P21-Rho-binding domain WD40 PF00400.32 ETO07750.1 - 4.7e-10 39.9 2.2 4.3e-06 27.4 0.3 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO07750.1 - 0.0031 16.2 0.0 0.004 15.9 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 SID-1_RNA_chan PF13965.6 ETO07750.1 - 0.0081 14.6 2.1 0.01 14.3 2.1 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 OAD_gamma PF04277.13 ETO07750.1 - 0.37 11.4 1.4 3.3 8.4 0.1 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Qua1 PF16274.5 ETO07750.1 - 1.2 9.0 8.5 0.44 10.4 0.4 2.5 2 1 0 2 2 2 0 Qua1 domain LMWPc PF01451.21 ETO07751.1 - 0.31 11.4 2.0 1.7 9.0 0.3 2.6 3 1 0 3 3 3 0 Low molecular weight phosphotyrosine protein phosphatase WD40 PF00400.32 ETO07752.1 - 5.6e-41 137.8 28.1 5.4e-07 30.2 2.7 7.5 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07752.1 - 9e-14 51.5 4.3 0.054 13.8 0.0 5.8 4 2 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07752.1 - 1.7e-12 46.8 10.6 0.023 13.3 0.1 6.0 3 3 2 6 6 6 6 Nucleoporin Nup120/160 MepB PF08877.10 ETO07752.1 - 0.13 11.9 0.0 0.34 10.6 0.0 1.6 1 0 0 1 1 1 0 MepB protein KIP1 PF07765.12 ETO07753.1 - 0.0017 18.4 0.9 0.0071 16.4 0.2 1.9 1 1 1 2 2 2 1 KIP1-like protein LpxI_N PF17930.1 ETO07753.1 - 0.0071 16.2 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 LpxI N-terminal domain HR1 PF02185.16 ETO07753.1 - 0.017 15.2 0.2 0.038 14.1 0.2 1.6 1 0 0 1 1 1 0 Hr1 repeat DUF2452 PF10504.9 ETO07753.1 - 0.04 13.4 0.1 0.056 12.9 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2452) Hira PF07569.11 ETO07753.1 - 0.11 12.2 1.1 0.14 11.8 1.1 1.2 1 1 0 1 1 1 0 TUP1-like enhancer of split DUF1657 PF07870.11 ETO07753.1 - 0.14 12.0 2.2 12 5.9 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1657) Kelch_2 PF07646.15 ETO07754.1 - 2.7e-07 30.3 0.3 0.0014 18.5 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO07754.1 - 3.6e-07 29.6 2.5 4.7e-07 29.3 0.1 2.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO07754.1 - 0.00021 21.2 1.2 0.005 16.8 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO07754.1 - 0.00039 20.6 0.6 0.039 14.2 0.3 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO07754.1 - 0.0026 17.7 1.3 0.14 12.2 0.8 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO07754.1 - 0.15 12.4 0.2 1.3 9.4 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Serinc PF03348.15 ETO07756.1 - 1.2e-18 67.3 22.3 2.3e-18 66.3 22.3 1.4 1 0 0 1 1 1 1 Serine incorporator (Serinc) BACK PF07707.15 ETO07757.1 - 6.7e-11 42.2 0.6 1.2e-06 28.6 0.5 2.1 2 0 0 2 2 2 2 BTB And C-terminal Kelch ODAM PF15424.6 ETO07757.1 - 0.0099 15.5 0.8 0.012 15.3 0.8 1.1 1 0 0 1 1 1 1 Odontogenic ameloblast-associated family BTB PF00651.31 ETO07758.1 - 0.052 13.8 0.0 0.076 13.3 0.0 1.3 1 0 0 1 1 1 0 BTB/POZ domain HSP70 PF00012.20 ETO07759.1 - 0.0046 15.2 3.8 0.0063 14.8 3.8 1.2 1 0 0 1 1 1 1 Hsp70 protein SAM_2 PF07647.17 ETO07759.1 - 0.011 15.9 0.7 21 5.3 0.0 3.9 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO07759.1 - 0.22 12.0 2.8 6.2 7.3 0.0 3.7 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) Pro_CA PF00484.19 ETO07759.1 - 0.51 10.6 2.3 1 9.7 2.3 1.5 1 0 0 1 1 1 0 Carbonic anhydrase DNA_pack_N PF02500.15 ETO07759.1 - 1.9 8.3 8.8 2.1 8.1 5.3 2.4 1 1 2 3 3 3 0 Probable DNA packing protein, N-terminus TINF2_N PF14973.6 ETO07759.1 - 2.2 8.6 9.8 0.75 10.1 1.8 2.8 2 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus APC_u15 PF16636.5 ETO07759.1 - 3.1 8.3 12.6 14 6.2 7.8 2.7 1 1 1 2 2 2 0 Unstructured region on APC between APC_crr regions 5 and 6 KilA-N PF04383.13 ETO07759.1 - 8.7 6.2 8.1 2 8.3 0.0 2.9 2 1 0 2 2 2 0 KilA-N domain Kelch_1 PF01344.25 ETO07760.1 - 0.0023 17.5 0.8 0.26 10.9 0.4 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO07760.1 - 0.029 14.7 2.3 0.17 12.3 0.3 2.9 2 1 1 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO07760.1 - 0.1 12.6 3.5 5 7.3 2.9 3.3 2 1 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO07761.1 - 6.8e-15 55.2 9.1 1.2e-06 29.2 0.6 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO07761.1 - 3.7e-05 22.6 1.7 0.0023 16.6 0.2 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07761.1 - 0.00062 20.0 0.0 0.0033 17.7 0.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain SspO PF08175.12 ETO07762.1 - 0.045 14.2 2.2 0.045 14.2 2.2 1.5 1 1 0 1 1 1 0 Small acid-soluble spore protein O family Tiam_CC_Ex PF18385.1 ETO07762.1 - 0.99 9.8 4.9 1.2 9.6 4.9 1.1 1 0 0 1 1 1 0 T-lymphoma invasion and metastasis CC-Ex domain Clathrin PF00637.20 ETO07765.1 - 4.9e-15 55.7 6.2 1.8e-09 37.6 2.0 2.7 1 1 1 2 2 2 2 Region in Clathrin and VPS Kelch_2 PF07646.15 ETO07766.1 - 1.6e-05 24.7 2.1 0.042 13.8 0.1 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO07766.1 - 3.3e-05 23.4 2.5 0.0045 16.5 0.1 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO07766.1 - 0.00018 21.6 1.0 5.2 7.5 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO07766.1 - 0.0011 19.0 0.1 0.015 15.3 0.0 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO07766.1 - 0.0088 16.3 0.1 0.14 12.5 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain IL3Ra_N PF18611.1 ETO07766.1 - 0.052 13.5 0.6 0.19 11.7 0.6 2.0 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain Kelch_5 PF13854.6 ETO07766.1 - 0.2 11.7 2.4 9.7 6.3 0.2 4.1 5 0 0 5 5 5 0 Kelch motif adh_short PF00106.25 ETO07767.1 - 1.7e-39 135.3 1.0 3.5e-39 134.3 1.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO07767.1 - 9e-27 94.1 0.6 2.2e-26 92.9 0.6 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO07767.1 - 2.2e-07 30.9 0.1 2.2e-06 27.7 0.0 2.0 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 ETO07767.1 - 0.00013 21.9 0.6 0.001 19.0 0.1 2.2 2 1 0 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 ETO07767.1 - 0.00044 19.8 0.4 0.0019 17.7 0.4 2.0 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1959 PF09218.10 ETO07767.1 - 0.043 13.9 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) Glyco_hydro_56 PF01630.18 ETO07767.1 - 0.11 11.5 0.1 0.13 11.2 0.1 1.2 1 0 0 1 1 1 0 Hyaluronidase AA_permease_2 PF13520.6 ETO07769.1 - 4.8e-35 121.2 21.2 4.8e-35 121.2 21.2 1.9 1 1 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETO07769.1 - 1.7e-19 69.8 24.4 3e-19 69.0 24.4 1.4 1 1 0 1 1 1 1 Amino acid permease DDE_Tnp_IS1595 PF12762.7 ETO07770.1 - 0.067 13.2 0.0 0.079 13.0 0.0 1.0 1 0 0 1 1 1 0 ISXO2-like transposase domain Peptidase_C14 PF00656.22 ETO07771.1 - 5.6e-08 33.0 0.2 9.2e-08 32.3 0.2 1.3 1 0 0 1 1 1 1 Caspase domain ubiquitin PF00240.23 ETO07772.1 - 0.0016 18.2 0.5 0.0038 16.9 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Kelch_4 PF13418.6 ETO07774.1 - 0.038 14.0 0.0 0.07 13.1 0.0 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain WD40 PF00400.32 ETO07775.1 - 1.7e-16 60.3 8.3 4.9e-06 27.2 0.0 4.3 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07775.1 - 0.00018 20.3 0.2 0.013 14.1 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 NPHI_C PF08469.10 ETO07775.1 - 0.023 14.6 1.1 3.2 7.7 0.1 2.4 2 0 0 2 2 2 0 Nucleoside triphosphatase I C-terminal ANAPC4_WD40 PF12894.7 ETO07775.1 - 0.033 14.5 0.2 4.3 7.7 0.1 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PHM7_cyt PF14703.6 ETO07776.1 - 0.0062 16.8 3.9 0.0062 16.8 3.9 2.2 1 1 1 2 2 2 1 Cytosolic domain of 10TM putative phosphate transporter PolyA_pol PF01743.20 ETO07776.1 - 0.0076 16.7 2.8 0.015 15.7 2.8 1.5 1 0 0 1 1 1 1 Poly A polymerase head domain DUF1644 PF07800.12 ETO07776.1 - 0.0096 16.0 0.7 0.0096 16.0 0.7 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1644) MRP-S32 PF10210.9 ETO07776.1 - 0.096 13.2 7.2 0.11 13.1 0.3 2.4 1 1 0 2 2 2 0 Mitochondrial 28S ribosomal protein S32 DUF1664 PF07889.12 ETO07776.1 - 0.17 11.9 13.9 0.8 9.7 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ETO07776.1 - 0.21 10.9 3.8 0.33 10.2 3.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) XLF PF09302.11 ETO07776.1 - 0.33 11.1 10.7 0.97 9.6 10.7 1.9 1 1 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Cnn_1N PF07989.11 ETO07776.1 - 1.1 9.4 17.2 2.6 8.2 6.3 3.1 2 2 0 2 2 2 0 Centrosomin N-terminal motif 1 HIP1_clath_bdg PF16515.5 ETO07776.1 - 1.1 9.9 12.1 1.5 9.5 5.9 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Med9 PF07544.13 ETO07776.1 - 1.9 8.6 16.9 2.5 8.3 8.2 3.0 2 2 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 UPF0242 PF06785.11 ETO07776.1 - 2.6 8.1 20.7 12 6.0 20.0 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus SOGA PF11365.8 ETO07776.1 - 3.1 9.0 10.9 10 7.4 4.6 2.8 2 2 0 2 2 2 0 Protein SOGA Phage_HK97_TLTM PF06120.11 ETO07776.1 - 4.8 6.3 19.1 2.6 7.1 9.6 2.5 1 1 0 2 2 2 0 Tail length tape measure protein DUF2203 PF09969.9 ETO07776.1 - 6.4 7.5 9.5 65 4.3 8.2 2.5 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) NPV_P10 PF05531.12 ETO07776.1 - 6.7 7.3 16.2 0.47 11.0 2.6 2.7 3 0 0 3 3 2 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 ETO07776.1 - 7.4 6.8 14.9 0.73 10.1 4.1 3.3 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Phage_TAC_5 PF08890.11 ETO07778.1 - 0.024 14.6 0.4 0.024 14.6 0.4 1.4 2 0 0 2 2 2 0 Phage XkdN-like tail assembly chaperone protein, TAC RRM_1 PF00076.22 ETO07779.1 - 4.2e-14 52.1 0.3 1.3e-07 31.3 0.0 3.9 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4283 PF14111.6 ETO07779.1 - 0.022 14.3 0.0 0.89 9.1 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4283) Somatomedin_B PF01033.17 ETO07780.1 - 2.9e-05 24.3 22.4 2.9e-05 24.3 22.4 3.4 3 1 1 4 4 4 2 Somatomedin B domain Exo_endo_phos PF03372.23 ETO07780.1 - 0.013 15.0 0.1 0.026 14.0 0.1 1.6 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ETO07780.1 - 0.029 14.2 2.6 0.045 13.6 1.2 2.0 2 1 0 2 2 2 0 Endonuclease-reverse transcriptase DAGAT PF03982.13 ETO07781.1 - 8.7e-36 123.3 0.0 9.6e-36 123.2 0.0 1.0 1 0 0 1 1 1 1 Diacylglycerol acyltransferase SBF_like PF13593.6 ETO07782.1 - 7.5e-63 212.7 29.9 4.4e-32 111.6 12.4 3.1 2 1 0 2 2 2 2 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 ETO07782.1 - 0.0073 16.0 8.1 0.0073 16.0 8.1 3.5 4 0 0 4 4 4 2 Sodium Bile acid symporter family DapH_N PF08503.10 ETO07783.1 - 1.8 8.9 5.8 4 7.7 0.3 2.8 1 1 1 3 3 3 0 Tetrahydrodipicolinate succinyltransferase N-terminal DUF789 PF05623.12 ETO07784.1 - 0.0058 16.4 0.5 0.0062 16.3 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF789) CSG2 PF16965.5 ETO07784.1 - 0.015 14.2 0.5 0.017 14.1 0.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator IRF PF00605.17 ETO07784.1 - 0.044 14.1 1.3 0.059 13.7 1.3 1.3 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor Ctr PF04145.15 ETO07784.1 - 0.059 14.0 0.5 0.074 13.7 0.5 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Baculo_E56 PF04639.12 ETO07784.1 - 0.066 12.5 0.1 0.081 12.2 0.1 1.1 1 0 0 1 1 1 0 Baculoviral E56 protein, specific to ODV envelope CHD5 PF04420.14 ETO07784.1 - 0.12 12.2 2.7 0.18 11.7 2.7 1.2 1 0 0 1 1 1 0 CHD5-like protein Pex2_Pex12 PF04757.14 ETO07785.1 - 0.018 14.6 8.9 0.045 13.3 4.0 2.4 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region FAM176 PF14851.6 ETO07785.1 - 0.14 11.8 7.0 0.49 10.0 0.4 2.2 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 ETO07785.1 - 0.34 10.9 15.0 0.17 11.9 2.7 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal Zip PF02535.22 ETO07785.1 - 0.63 9.2 1.5 1.6 7.9 0.4 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Rad54_N PF08658.10 ETO07785.1 - 0.7 10.0 7.9 3.9 7.6 0.1 2.1 2 0 0 2 2 2 0 Rad54 N terminal DUF4611 PF15387.6 ETO07785.1 - 1.2 9.4 12.8 0.55 10.5 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 ETO07785.1 - 1.5 9.3 16.8 0.11 12.9 5.0 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Secretin_N_2 PF07655.13 ETO07785.1 - 2.9 8.5 23.2 1.6 9.3 14.8 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF1863 PF08937.11 ETO07785.1 - 3.5 7.9 13.3 4 7.8 5.7 2.3 2 0 0 2 2 2 0 MTH538 TIR-like domain (DUF1863) SOBP PF15279.6 ETO07787.1 - 0.13 12.8 9.3 0.21 12.2 9.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF2070 PF09843.9 ETO07787.1 - 0.21 9.9 3.8 0.39 9.0 3.8 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Neur_chan_memb PF02932.16 ETO07787.1 - 6.3 6.8 11.6 14 5.6 11.6 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region WD40 PF00400.32 ETO07788.1 - 5.6e-58 191.6 11.4 3e-11 43.7 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07788.1 - 1.8e-18 66.6 1.8 4.9e-06 26.8 0.1 5.8 2 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07788.1 - 8e-14 51.3 2.8 0.12 11.3 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO07788.1 - 1.1e-08 34.3 9.2 0.072 11.7 0.0 6.7 2 1 6 8 8 8 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07788.1 - 4.5e-08 32.8 3.8 0.058 12.7 0.1 3.5 3 1 1 4 4 4 3 WD40-like domain Coatomer_WDAD PF04053.14 ETO07788.1 - 1e-06 28.1 1.0 0.0066 15.5 0.1 2.6 1 1 2 3 3 3 2 Coatomer WD associated region DPPIV_N PF00930.21 ETO07788.1 - 1.4e-05 24.1 0.9 0.0061 15.4 0.5 3.2 2 2 0 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO07788.1 - 1.6e-05 24.7 5.0 1 9.4 0.0 5.6 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO07788.1 - 2.7e-05 23.3 5.5 0.85 8.5 0.1 4.9 2 2 3 5 5 5 2 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO07788.1 - 0.00031 20.8 0.1 1.8 8.7 0.0 3.8 4 1 1 5 5 5 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO07788.1 - 0.021 13.4 0.3 18 3.7 0.0 3.2 1 1 1 3 3 3 0 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO07788.1 - 0.046 13.3 0.2 8.3 5.9 0.0 2.8 1 1 2 3 3 3 0 PQQ-like domain Ricin_B_lectin PF00652.22 ETO07788.1 - 0.097 12.9 0.5 5.5 7.2 0.1 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain FA_desaturase PF00487.24 ETO07789.1 - 1.7e-15 57.6 7.8 2.1e-15 57.2 7.8 1.1 1 0 0 1 1 1 1 Fatty acid desaturase F_bP_aldolase PF01116.20 ETO07789.1 - 0.077 12.5 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-II zf-CW PF07496.15 ETO07791.1 - 2.4e-12 46.7 3.9 5.5e-12 45.5 3.9 1.7 1 0 0 1 1 1 1 CW-type Zinc Finger WD40 PF00400.32 ETO07792.1 - 0.014 16.3 0.2 2.3 9.2 0.0 3.6 4 0 0 4 4 4 0 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO07792.1 - 0.017 14.1 0.5 0.026 13.5 0.3 1.4 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein RL11D PF11088.8 ETO07792.1 - 0.13 12.6 3.9 0.22 11.8 2.5 1.9 2 0 0 2 2 2 0 Glycoprotein encoding membrane proteins RL5A and RL6 AAA_31 PF13614.6 ETO07795.1 - 2e-22 80.0 0.1 3.7e-22 79.1 0.1 1.4 1 0 0 1 1 1 1 AAA domain MipZ PF09140.11 ETO07795.1 - 2.2e-05 23.9 0.0 3.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 ATPase MipZ CBP_BcsQ PF06564.12 ETO07795.1 - 0.00012 21.6 0.0 0.00033 20.2 0.0 1.7 2 0 0 2 2 2 1 Cellulose biosynthesis protein BcsQ CbiA PF01656.23 ETO07795.1 - 0.00053 20.0 0.1 0.00072 19.6 0.1 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ParA PF10609.9 ETO07795.1 - 0.008 15.6 0.0 0.014 14.8 0.0 1.5 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase COG5 PF10392.9 ETO07795.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Mce4_CUP1 PF11887.8 ETO07795.1 - 0.092 12.2 0.6 0.16 11.4 0.1 1.7 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative WD40 PF00400.32 ETO07797.1 - 2.7e-08 34.3 3.1 0.0019 19.0 0.2 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO07797.1 - 0.011 14.5 0.2 0.027 13.2 0.1 1.7 1 1 1 2 2 2 0 Nup133 N terminal like DNA_pol3_alpha PF07733.12 ETO07797.1 - 0.019 14.6 0.1 0.021 14.4 0.1 1.1 1 0 0 1 1 1 0 Bacterial DNA polymerase III alpha NTPase domain SoDot-IcmSS PF16848.5 ETO07798.1 - 0.041 13.9 0.0 0.056 13.4 0.0 1.3 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative PH PF00169.29 ETO07800.1 - 3.5e-07 30.7 2.6 0.0011 19.4 0.3 3.6 2 0 0 2 2 2 2 PH domain PH_11 PF15413.6 ETO07800.1 - 0.00062 20.2 0.5 0.00062 20.2 0.5 7.0 7 2 1 8 8 8 2 Pleckstrin homology domain Ras PF00071.22 ETO07801.1 - 8.3e-42 142.5 3.2 6.1e-41 139.7 0.3 2.6 2 1 0 2 2 2 1 Ras family Roc PF08477.13 ETO07801.1 - 1.2e-22 80.3 0.1 1.8e-21 76.6 0.1 2.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PAE PF03283.13 ETO07801.1 - 1.8e-22 80.0 1.9 4.8e-22 78.6 1.9 1.8 1 0 0 1 1 1 1 Pectinacetylesterase Arf PF00025.21 ETO07801.1 - 2.5e-11 43.4 3.0 3.1e-10 39.8 0.2 3.0 2 1 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO07801.1 - 0.0089 16.1 0.0 0.022 14.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase SUKH_6 PF14568.6 ETO07801.1 - 0.039 14.4 1.2 0.077 13.4 0.1 2.1 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall DUF809 PF05663.11 ETO07801.1 - 0.043 14.0 0.1 0.14 12.3 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF809) RsgA_GTPase PF03193.16 ETO07801.1 - 0.066 13.1 2.6 4.5 7.1 0.0 2.8 3 0 0 3 3 3 0 RsgA GTPase WD40 PF00400.32 ETO07802.1 - 2.5e-05 25.0 2.6 0.00012 22.7 1.0 2.6 2 1 0 2 2 2 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO07802.1 - 0.056 12.2 0.1 0.056 12.2 0.1 1.2 1 0 0 1 1 1 0 Nup133 N terminal like Nup160 PF11715.8 ETO07802.1 - 0.061 12.0 0.0 0.061 12.0 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 zf-RING-like PF08746.11 ETO07803.1 - 0.04 14.2 0.9 0.76 10.1 0.3 2.8 2 1 0 2 2 2 0 RING-like domain PRR20 PF15708.5 ETO07804.1 - 0.016 15.1 2.7 0.016 15.1 2.7 1.7 1 1 0 1 1 1 0 Proline-rich protein family 20 WD40 PF00400.32 ETO07805.1 - 5.9e-41 137.7 23.4 2.9e-07 31.1 0.5 8.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07805.1 - 3.5e-12 46.4 0.1 0.067 13.5 0.0 5.8 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07805.1 - 6.4e-11 41.6 2.5 0.027 13.1 0.3 5.5 1 1 2 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO07805.1 - 0.00011 22.8 0.8 0.00043 20.9 0.4 2.3 1 1 1 2 2 2 1 TRAF-type zinc finger PQQ_3 PF13570.6 ETO07805.1 - 0.25 11.9 0.8 35 5.0 0.0 4.3 5 0 0 5 5 5 0 PQQ-like domain EP400_N PF15790.5 ETO07805.1 - 0.42 9.4 2.1 0.78 8.5 2.1 1.4 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal CSRNP_N PF16019.5 ETO07805.1 - 1.1 9.1 12.0 3.1 7.7 12.0 1.8 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus WD40_like PF17005.5 ETO07805.1 - 2.1 7.6 10.6 1.8 7.8 0.2 4.2 2 2 1 4 4 4 0 WD40-like domain RGS PF00615.19 ETO07808.1 - 0.02 15.2 1.2 5.6 7.3 0.1 2.4 2 0 0 2 2 2 0 Regulator of G protein signaling domain 7tm_3 PF00003.22 ETO07809.1 - 0.0019 17.9 3.5 0.0026 17.5 3.5 1.1 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Connexin PF00029.19 ETO07809.1 - 0.021 14.6 1.7 0.021 14.6 1.7 2.9 1 1 1 2 2 2 0 Connexin LAP1C PF05609.12 ETO07809.1 - 0.042 13.0 16.1 0.052 12.7 16.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RRN3 PF05327.11 ETO07809.1 - 0.64 8.5 15.5 0.92 8.0 15.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RhoGAP PF00620.27 ETO07810.1 - 0.022 14.6 0.1 0.032 14.1 0.1 1.2 1 0 0 1 1 1 0 RhoGAP domain Actin PF00022.19 ETO07811.1 - 1.2e-18 66.9 0.0 1.8e-18 66.4 0.0 1.2 1 0 0 1 1 1 1 Actin Pyrophosphatase PF00719.19 ETO07813.1 - 1e-40 139.2 0.1 1.4e-40 138.7 0.1 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase DUF365 PF04033.12 ETO07816.1 - 0.57 10.5 4.7 0.23 11.8 0.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF365) Csm1_N PF18504.1 ETO07819.1 - 0.0053 17.1 3.6 0.0053 17.1 3.6 2.7 2 0 0 2 2 2 1 Csm1 N-terminal domain PKcGMP_CC PF16808.5 ETO07819.1 - 1.6 8.6 13.6 2.7 7.9 9.3 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GSHPx PF00255.19 ETO07820.1 - 3.6e-35 119.8 0.1 5.9e-35 119.1 0.1 1.3 1 0 0 1 1 1 1 Glutathione peroxidase WD40 PF00400.32 ETO07821.1 - 5.9e-22 77.6 2.2 2.1e-06 28.3 0.0 5.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07821.1 - 4.8e-08 33.2 0.2 0.44 10.9 0.0 5.2 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO07821.1 - 4.6e-07 29.1 0.0 0.045 12.7 0.0 4.0 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO07821.1 - 0.00028 20.7 5.5 3.7 7.6 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO07821.1 - 0.0081 16.1 0.1 1.9 8.6 0.1 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO07821.1 - 0.013 15.4 0.0 0.71 9.9 0.0 3.6 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO07821.1 - 0.083 12.5 0.6 19 5.0 0.1 3.3 3 0 0 3 3 3 0 Kelch motif Rop-like PF05082.13 ETO07822.1 - 0.0015 18.3 1.1 0.0027 17.5 1.1 1.4 1 0 0 1 1 1 1 Rop-like SlyX PF04102.12 ETO07822.1 - 0.022 15.4 1.0 0.065 13.9 1.0 1.7 1 0 0 1 1 1 0 SlyX DUF1043 PF06295.12 ETO07822.1 - 0.024 14.6 4.3 0.051 13.6 4.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Striatin PF08232.12 ETO07822.1 - 0.52 10.9 7.0 0.13 12.9 3.7 1.6 2 0 0 2 2 2 0 Striatin family Corazonin PF17308.2 ETO07822.1 - 2.7 8.4 12.7 0.61 10.5 8.0 2.2 2 0 0 2 2 2 0 Pro-corazonin TCP PF03634.13 ETO07822.1 - 5.9 7.4 15.8 0.21 12.2 6.7 2.1 2 0 0 2 2 2 0 TCP family transcription factor Alpha_L_fucos PF01120.17 ETO07823.1 - 0.0061 16.1 0.2 0.0066 15.9 0.2 1.0 1 0 0 1 1 1 1 Alpha-L-fucosidase DUF1666 PF07891.12 ETO07823.1 - 0.16 11.7 4.3 0.18 11.4 4.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1666) SWIRM PF04433.17 ETO07824.1 - 4.8e-11 42.9 0.1 1.1e-10 41.7 0.1 1.6 1 0 0 1 1 1 1 SWIRM domain SRP-alpha_N PF04086.13 ETO07824.1 - 2.6 7.9 20.9 3.2 7.6 20.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOBP PF15279.6 ETO07824.1 - 3.1 8.3 21.1 4.1 7.9 21.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Tubulin PF00091.25 ETO07825.1 - 4.8e-55 186.8 0.1 1.3e-54 185.4 0.1 1.7 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO07825.1 - 2e-41 141.1 0.0 3.4e-41 140.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ETO07825.1 - 0.017 14.8 0.0 0.048 13.3 0.0 1.8 2 1 0 2 2 2 0 Tubulin domain Cpn60_TCP1 PF00118.24 ETO07830.1 - 2.2e-44 151.9 0.9 2.7e-44 151.7 0.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Lipoprotein_3 PF00938.17 ETO07832.1 - 0.035 14.3 0.1 0.11 12.8 0.1 1.9 1 0 0 1 1 1 0 Lipoprotein TAF6_C PF07571.13 ETO07832.1 - 0.062 13.6 0.1 11 6.5 0.0 2.4 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain MRP-L20 PF12824.7 ETO07833.1 - 0.028 14.6 0.6 0.038 14.1 0.6 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit L20 LEF-4 PF05098.12 ETO07834.1 - 0.02 13.7 0.0 0.022 13.6 0.0 1.0 1 0 0 1 1 1 0 Late expression factor 4 (LEF-4) Crp PF00325.20 ETO07834.1 - 0.25 11.0 1.2 0.42 10.3 1.2 1.3 1 0 0 1 1 1 0 Bacterial regulatory proteins, crp family Ank_2 PF12796.7 ETO07837.1 - 3.3e-11 43.6 0.4 0.0013 19.3 0.0 4.0 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO07837.1 - 2.1e-05 25.0 0.2 0.045 14.4 0.0 4.3 3 2 2 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO07837.1 - 0.00017 21.7 0.0 3 8.7 0.0 5.0 5 0 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 ETO07837.1 - 0.014 15.7 0.0 37 4.8 0.0 4.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) YnfE PF17452.2 ETO07837.1 - 1.1 9.7 6.8 1.3 9.4 1.0 3.3 2 1 1 3 3 3 0 Uncharacterized YnfE-like NuA4 PF09340.10 ETO07838.1 - 0.005 16.7 0.5 0.005 16.7 0.5 2.6 3 1 0 3 3 3 1 Histone acetyltransferase subunit NuA4 TrbC_Ftype PF09673.10 ETO07838.1 - 0.087 12.9 1.1 0.2 11.7 0.2 2.1 2 0 0 2 2 2 0 Type-F conjugative transfer system pilin assembly protein VBS PF08913.10 ETO07838.1 - 0.094 13.2 1.8 0.76 10.2 1.9 2.4 2 1 0 2 2 2 0 Vinculin Binding Site VPS11_C PF12451.8 ETO07838.1 - 0.34 11.2 2.2 1.2 9.4 2.2 2.0 1 0 0 1 1 1 0 Vacuolar protein sorting protein 11 C terminal EF-hand_2 PF09068.11 ETO07839.1 - 4.1 7.6 9.5 17 5.6 9.7 2.2 1 1 0 1 1 1 0 EF hand UPF0449 PF15136.6 ETO07839.1 - 5.3 7.6 18.0 0.36 11.3 0.7 3.2 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 CH_2 PF06294.11 ETO07841.1 - 1.2e-33 115.1 0.3 1.2e-33 115.1 0.3 3.0 2 1 1 3 3 3 1 CH-like domain in sperm protein CAMSAP_CH PF11971.8 ETO07841.1 - 1e-15 57.3 0.1 2e-15 56.4 0.1 1.5 1 0 0 1 1 1 1 CAMSAP CH domain Secretin_N_2 PF07655.13 ETO07841.1 - 0.058 14.0 8.5 0.12 12.9 8.5 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain TRAF_BIRC3_bd PF16673.5 ETO07841.1 - 0.18 11.6 4.9 1.7 8.5 3.0 3.0 2 1 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain FAM76 PF16046.5 ETO07841.1 - 0.57 9.5 10.3 0.73 9.1 10.3 1.3 1 0 0 1 1 1 0 FAM76 protein DARPP-32 PF05395.12 ETO07841.1 - 1 9.6 6.5 1.5 9.1 6.5 1.3 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 NOA36 PF06524.12 ETO07841.1 - 1.2 8.4 11.4 1.6 7.9 11.4 1.2 1 0 0 1 1 1 0 NOA36 protein Fib_alpha PF08702.10 ETO07841.1 - 6.7 6.9 17.6 28 4.9 17.6 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Orf78 PF06024.12 ETO07841.1 - 8.9 6.7 10.6 24 5.3 10.6 1.9 1 0 0 1 1 1 0 Orf78 (ac78) Peptidase_C1 PF00112.23 ETO07842.1 - 1.1e-64 218.5 14.6 3.4e-40 138.5 4.3 2.3 1 1 1 2 2 2 2 Papain family cysteine protease Inhibitor_I29 PF08246.12 ETO07842.1 - 5.8e-14 52.3 0.3 1.3e-13 51.1 0.3 1.7 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ETO07842.1 - 1.8e-06 27.1 1.5 0.0038 16.0 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family WD40 PF00400.32 ETO07843.1 - 9.1e-20 70.6 19.8 1.2e-07 32.3 0.3 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07843.1 - 5.8e-07 29.7 0.1 0.068 13.5 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07843.1 - 7.7e-06 24.8 3.6 0.006 15.3 1.0 2.7 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07843.1 - 0.00089 18.7 0.5 0.012 15.0 0.5 2.1 1 1 0 2 2 2 1 WD40-like domain AAR2 PF05282.11 ETO07845.1 - 0.00072 19.1 4.8 0.00089 18.8 4.8 1.1 1 0 0 1 1 1 1 AAR2 protein CDC45 PF02724.14 ETO07845.1 - 0.00077 17.9 7.1 0.0011 17.4 7.1 1.2 1 0 0 1 1 1 1 CDC45-like protein Mem_trans PF03547.18 ETO07845.1 - 0.036 12.4 2.7 0.051 12.0 2.7 1.2 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 ETO07845.1 - 0.33 9.7 9.8 0.54 9.0 9.8 1.4 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO07845.1 - 0.36 10.0 8.3 0.12 11.6 5.3 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Nmad2 PF18753.1 ETO07845.1 - 0.38 10.2 10.9 0.1 12.1 7.8 1.5 2 0 0 2 2 2 0 Nucleotide modification associated domain 2 Menin PF05053.13 ETO07845.1 - 4 5.7 13.0 5.6 5.2 13.0 1.2 1 0 0 1 1 1 0 Menin RR_TM4-6 PF06459.12 ETO07845.1 - 7.7 6.3 15.1 0.37 10.6 7.4 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 ETO07845.1 - 9.4 4.9 9.6 2 7.2 5.6 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter 7tm_2 PF00002.24 ETO07846.1 - 4.7e-05 22.8 7.9 6.5e-05 22.3 7.9 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (Secretin family) DUF3301 PF11743.8 ETO07846.1 - 0.063 13.0 0.0 0.95 9.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) SLC3A2_N PF16028.5 ETO07846.1 - 0.29 10.7 0.1 0.29 10.7 0.1 2.2 3 0 0 3 3 3 0 Solute carrier family 3 member 2 N-terminus DUF4284 PF14112.6 ETO07847.1 - 0.04 14.8 3.8 0.083 13.8 2.4 2.3 1 1 0 2 2 2 0 Immunity protein 22 B-block_TFIIIC PF04182.12 ETO07849.1 - 2.6e-08 33.9 0.1 0.00024 21.2 0.0 2.8 2 0 0 2 2 2 2 B-block binding subunit of TFIIIC DUF3791 PF12668.7 ETO07849.1 - 0.006 16.6 1.6 0.14 12.3 0.2 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF3791) Flavodoxin_3 PF12641.7 ETO07849.1 - 0.27 10.9 3.3 0.2 11.4 0.7 2.0 2 0 0 2 2 2 0 Flavodoxin domain NAPRTase_C PF17956.1 ETO07850.1 - 0.087 13.3 1.4 2.8 8.4 0.1 2.4 2 1 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain DUF4471 PF14740.6 ETO07851.1 - 0.023 13.9 0.1 0.026 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) INSC_LBD PF16748.5 ETO07852.1 - 0.11 12.0 0.3 0.11 12.0 0.3 1.9 2 0 0 2 2 2 0 Inscuteable LGN-binding domain UPF0370 PF13980.6 ETO07854.1 - 0.16 12.0 2.7 0.17 11.9 0.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) DUF4203 PF13886.6 ETO07855.1 - 0.038 13.7 1.0 0.077 12.7 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4203) Nop52 PF05997.12 ETO07856.1 - 6.8e-32 111.0 3.5 1.3e-31 110.1 3.5 1.5 1 1 0 1 1 1 1 Nucleolar protein,Nop52 Sod_Cu PF00080.20 ETO07858.1 - 0.0021 18.2 0.2 0.026 14.7 0.1 2.7 2 1 0 2 2 2 1 Copper/zinc superoxide dismutase (SODC) Peptidase_C14 PF00656.22 ETO07859.1 - 1.2e-13 51.6 1.6 2.1e-13 50.8 1.6 1.3 1 0 0 1 1 1 1 Caspase domain NOGCT PF08155.11 ETO07859.1 - 0.011 15.7 0.5 0.042 13.8 0.2 2.2 2 0 0 2 2 2 0 NOGCT (NUC087) domain Lumazine_bd_2 PF12893.7 ETO07859.1 - 0.034 14.8 0.0 0.072 13.8 0.0 1.5 1 0 0 1 1 1 0 Putative lumazine-binding AAA_9 PF12781.7 ETO07860.1 - 1.1e-43 149.0 3.4 2.8e-29 101.8 0.0 4.8 4 1 1 5 5 5 2 ATP-binding dynein motor region MT PF12777.7 ETO07860.1 - 3.2e-41 141.5 10.4 6.7e-41 140.4 10.4 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 ETO07860.1 - 3e-29 101.5 0.5 1.8e-28 99.0 0.0 2.7 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 ETO07860.1 - 1.6e-23 83.3 0.0 3.7e-23 82.1 0.0 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Fez1 PF06818.15 ETO07860.1 - 8.4e-06 26.4 28.5 4.8e-05 23.9 1.7 3.4 3 0 0 3 3 3 2 Fez1 BRE1 PF08647.11 ETO07860.1 - 0.00035 20.6 12.3 0.00035 20.6 12.3 4.2 3 1 0 3 3 2 1 BRE1 E3 ubiquitin ligase BST2 PF16716.5 ETO07860.1 - 0.0013 19.2 5.5 0.0013 19.2 5.5 4.1 3 1 0 3 3 2 1 Bone marrow stromal antigen 2 POT1PC PF16686.5 ETO07860.1 - 0.13 12.1 1.7 0.21 11.5 0.0 2.2 3 0 0 3 3 3 0 ssDNA-binding domain of telomere protection protein FapA PF03961.13 ETO07860.1 - 0.34 9.5 25.8 0.016 13.8 3.0 3.2 3 0 0 3 3 3 0 Flagellar Assembly Protein A Tropomyosin PF00261.20 ETO07860.1 - 0.71 9.2 43.7 0.49 9.7 10.3 3.4 3 0 0 3 3 3 0 Tropomyosin Spc7 PF08317.11 ETO07860.1 - 1.2 7.9 39.7 0.14 11.0 8.2 3.5 3 0 0 3 3 3 0 Spc7 kinetochore protein Exonuc_VII_L PF02601.15 ETO07860.1 - 2.6 7.5 27.9 0.25 10.9 1.9 3.2 3 0 0 3 3 3 0 Exonuclease VII, large subunit WXG100 PF06013.12 ETO07860.1 - 8.7 6.7 12.0 5.4 7.3 1.2 3.6 4 0 0 4 4 3 0 Proteins of 100 residues with WXG Atg14 PF10186.9 ETO07860.1 - 9.1 5.3 30.6 0.011 14.9 4.2 3.7 4 0 0 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 Orf78 PF06024.12 ETO07862.1 - 0.0052 17.1 1.0 0.0069 16.7 1.0 1.2 1 0 0 1 1 1 1 Orf78 (ac78) Tubulin PF00091.25 ETO07863.1 - 1.2e-57 195.3 0.4 1.9e-57 194.7 0.4 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO07863.1 - 4.3e-36 123.9 0.1 9.3e-36 122.8 0.1 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF4869 PF16163.5 ETO07864.1 - 0.0053 16.5 2.4 0.019 14.6 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4869) DUF2660 PF10859.8 ETO07864.1 - 0.015 15.7 1.5 0.079 13.4 1.5 2.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2660) DUF1810 PF08837.11 ETO07864.1 - 0.037 13.8 0.7 2.5 7.9 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1810) IL13 PF03487.13 ETO07864.1 - 0.093 12.5 1.0 11 5.8 0.0 3.1 2 0 0 2 2 2 0 Interleukin-13 ELMO_CED12 PF04727.13 ETO07864.1 - 9.9 6.2 9.3 1.2 9.2 0.8 3.2 3 0 0 3 3 3 0 ELMO/CED-12 family ATP-synt_ab_N PF02874.23 ETO07867.1 - 8.1e-06 26.3 0.0 1.7e-05 25.2 0.0 1.5 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain G-alpha PF00503.20 ETO07868.1 - 1.1e-24 87.3 1.4 3.5e-17 62.6 0.2 2.1 2 0 0 2 2 2 2 G-protein alpha subunit SDA1 PF05285.12 ETO07869.1 - 0.0012 18.4 16.7 0.0015 18.1 16.7 1.1 1 0 0 1 1 1 1 SDA1 Hid1 PF12722.7 ETO07869.1 - 0.4 8.7 7.1 0.39 8.8 7.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein V_ATPase_I PF01496.19 ETO07869.1 - 1.9 6.3 6.7 2.1 6.1 6.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ETO07869.1 - 2.5 6.3 17.0 3 6.0 17.0 1.2 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ETO07869.1 - 3.2 6.4 13.6 3.9 6.2 13.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO07869.1 - 3.7 5.8 14.9 4 5.7 14.9 1.1 1 0 0 1 1 1 0 Menin Membralin PF09746.9 ETO07869.1 - 5.8 5.8 8.5 7.4 5.5 8.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein His_Phos_1 PF00300.22 ETO07870.1 - 6.9e-05 22.6 0.0 0.0025 17.5 0.0 2.2 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Apt1 PF10351.9 ETO07872.1 - 0.1 11.4 11.5 0.082 11.7 10.5 1.3 1 1 0 1 1 1 0 Golgi-body localisation protein domain Spc7 PF08317.11 ETO07872.1 - 0.34 9.7 19.3 0.47 9.3 19.3 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 ETO07872.1 - 0.34 10.9 7.3 1 9.4 7.3 1.7 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Syntaxin-6_N PF09177.11 ETO07872.1 - 0.72 10.5 12.2 31 5.2 12.2 2.1 1 1 0 1 1 1 0 Syntaxin 6, N-terminal P4Ha_N PF08336.11 ETO07872.1 - 0.92 9.5 15.1 1 9.4 9.6 2.3 1 1 1 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region SICA_alpha PF12887.7 ETO07872.1 - 1.1 9.2 13.5 0.14 12.0 9.2 1.7 1 1 1 2 2 2 0 SICA extracellular alpha domain Exonuc_VII_L PF02601.15 ETO07872.1 - 1.2 8.6 14.2 1.7 8.2 14.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit GvpL_GvpF PF06386.11 ETO07872.1 - 2.4 8.0 8.1 0.19 11.6 1.6 1.9 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF DUF883 PF05957.13 ETO07872.1 - 2.6 8.7 6.8 2 9.1 4.7 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Seryl_tRNA_N PF02403.22 ETO07872.1 - 4.7 7.5 18.6 4.9 7.4 10.3 2.1 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 ETO07872.1 - 6.5 6.0 17.0 12 5.2 17.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3482 PF11981.8 ETO07872.1 - 7.3 5.9 10.2 1.1 8.6 5.8 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3482) DUF4349 PF14257.6 ETO07872.1 - 9.4 5.6 8.4 34 3.8 8.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) Mit_KHE1 PF10173.9 ETO07872.1 - 10 6.2 9.2 14 5.7 9.2 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related XRN_N PF03159.18 ETO07873.1 - 1.5e-70 237.4 0.1 1.5e-70 237.4 0.1 2.0 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus CDC45 PF02724.14 ETO07873.1 - 0.14 10.4 16.5 0.24 9.7 16.5 1.4 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO07873.1 - 0.27 9.3 21.4 0.38 8.8 21.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2076 PF09849.9 ETO07873.1 - 0.45 10.5 14.8 0.71 9.9 14.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Pex2_Pex12 PF04757.14 ETO07873.1 - 0.63 9.6 4.1 4.8 6.7 4.0 2.2 1 1 0 1 1 1 0 Pex2 / Pex12 amino terminal region PRC2_HTH_1 PF18118.1 ETO07873.1 - 0.79 10.6 12.8 0.66 10.8 10.2 2.1 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain Nop25 PF09805.9 ETO07873.1 - 2.4 8.6 22.3 0.15 12.6 15.8 2.0 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) Striatin PF08232.12 ETO07873.1 - 3.4 8.2 12.4 7 7.2 11.3 1.9 2 0 0 2 2 2 0 Striatin family DAG_kinase_N PF14513.6 ETO07873.1 - 3.6 7.8 11.6 0.83 9.8 8.4 1.5 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus XRN_M PF17846.1 ETO07874.1 - 5.3e-57 193.7 4.8 9.3e-57 192.9 2.6 2.0 1 1 0 2 2 2 1 Xrn1 helical domain XRN1_D1 PF18332.1 ETO07874.1 - 5.1e-24 85.1 0.0 1.1e-23 84.0 0.0 1.5 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain WD40 PF00400.32 ETO07875.1 - 4.3e-37 125.5 29.3 6.4e-07 30.0 0.2 8.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07875.1 - 3.2e-10 40.2 4.7 0.015 15.6 0.1 6.0 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO07875.1 - 7.7e-07 29.7 4.1 7.7e-07 29.7 4.1 3.4 5 0 0 5 5 5 1 TRAF-type zinc finger LacAB_rpiB PF02502.18 ETO07875.1 - 0.034 14.2 0.0 0.082 12.9 0.0 1.6 1 0 0 1 1 1 0 Ribose/Galactose Isomerase CEP63 PF17045.5 ETO07875.1 - 0.096 12.6 6.6 0.16 11.9 6.6 1.2 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Laminin_II PF06009.12 ETO07875.1 - 0.56 10.2 4.9 1.1 9.2 4.9 1.5 1 0 0 1 1 1 0 Laminin Domain II Jnk-SapK_ap_N PF09744.9 ETO07875.1 - 0.76 10.0 7.2 1.6 9.0 7.2 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.5 ETO07875.1 - 2.3 8.5 11.1 1.4 9.2 4.1 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DivIC PF04977.15 ETO07875.1 - 3.1 7.6 6.3 0.84 9.4 0.9 2.3 1 1 1 2 2 2 0 Septum formation initiator DAP_B PF07930.12 ETO07876.1 - 0.022 14.7 0.3 0.022 14.7 0.3 2.3 2 1 0 3 3 3 0 D-aminopeptidase, domain B Pkinase PF00069.25 ETO07877.1 - 9.4e-42 143.2 0.1 1.3e-40 139.5 0.1 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO07877.1 - 1.5e-21 76.9 0.1 4.7e-12 45.7 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO07877.1 - 0.00022 20.7 0.0 0.084 12.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ETO07877.1 - 0.00024 20.5 0.1 0.00038 19.9 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO07877.1 - 0.0045 15.8 0.0 0.0057 15.5 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase DUF1104 PF06518.11 ETO07878.1 - 0.06 13.7 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1104) AP4E_app_platf PF14807.6 ETO07880.1 - 0.13 12.7 1.3 0.35 11.3 0.2 2.1 2 0 0 2 2 2 0 Adaptin AP4 complex epsilon appendage platform WD40 PF00400.32 ETO07881.1 - 2.4e-33 113.6 19.9 4.4e-06 27.3 0.5 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07881.1 - 9.6e-11 41.8 0.9 0.0079 16.5 0.0 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07881.1 - 2.4e-10 39.7 3.5 0.0021 16.8 0.4 4.7 4 1 1 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07881.1 - 2.6e-06 27.0 7.9 0.0035 16.7 1.7 4.5 2 2 3 5 5 5 2 WD40-like domain SH3_13 PF18335.1 ETO07881.1 - 0.00065 19.5 1.5 2.2 8.2 0.1 3.6 3 0 0 3 3 3 2 ATP-dependent RecD-like DNA helicase SH3 domain DUF4221 PF13970.6 ETO07881.1 - 0.023 14.3 1.9 0.064 12.8 1.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4221) WD40 PF00400.32 ETO07882.1 - 6e-13 49.0 11.8 0.00048 20.9 0.3 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07882.1 - 8.4e-06 26.0 0.6 0.0045 17.3 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07882.1 - 0.0015 17.3 0.3 0.0049 15.6 0.2 1.8 2 1 0 2 2 2 1 Nucleoporin Nup120/160 Carbam_trans_C PF16861.5 ETO07883.1 - 0.035 13.7 0.6 0.74 9.4 0.1 2.3 1 1 0 2 2 2 0 Carbamoyltransferase C-terminus Lebercilin PF15619.6 ETO07883.1 - 0.38 10.4 3.9 0.11 12.1 0.5 1.9 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Sigma70_ner PF04546.13 ETO07884.1 - 0.0016 18.3 6.4 0.0018 18.2 6.4 1.0 1 0 0 1 1 1 1 Sigma-70, non-essential region TetR PF13972.6 ETO07884.1 - 0.037 13.7 0.3 0.077 12.7 0.2 1.5 1 1 0 1 1 1 0 Bacterial transcriptional repressor GCN5L1 PF06320.13 ETO07884.1 - 0.075 13.2 4.5 0.11 12.7 4.5 1.3 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) DUF4806 PF16064.5 ETO07884.1 - 0.077 13.3 1.9 0.11 12.8 1.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4806) DUF1759 PF03564.15 ETO07884.1 - 0.13 12.2 2.5 0.2 11.6 2.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1759) Rho_Binding PF08912.11 ETO07884.1 - 0.53 11.1 10.9 1.7 9.5 5.7 2.1 2 0 0 2 2 2 0 Rho Binding AAA_23 PF13476.6 ETO07884.1 - 1.6 9.2 8.0 1.8 9.0 8.0 1.1 1 0 0 1 1 1 0 AAA domain DUF4404 PF14357.6 ETO07884.1 - 1.8 9.3 6.5 6.2 7.5 6.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4404) DUF503 PF04456.12 ETO07885.1 - 0.03 14.2 0.3 3.3 7.6 0.2 3.7 2 1 0 3 3 3 0 Protein of unknown function (DUF503) Rsbr_N PF08678.10 ETO07885.1 - 0.17 11.9 5.3 0.11 12.5 0.7 2.9 2 1 1 3 3 3 0 Rsbr N terminal PI_PP_I PF18363.1 ETO07885.1 - 0.46 10.7 11.6 0.7 10.1 0.4 4.5 5 1 0 5 5 5 0 Phosphoinositide phosphatase insertion domain RGS PF00615.19 ETO07885.1 - 1.4 9.2 7.4 0.23 11.7 0.8 2.9 2 1 0 2 2 2 0 Regulator of G protein signaling domain DUF3336 PF11815.8 ETO07885.1 - 4.9 6.9 14.5 0.37 10.5 0.2 4.4 3 2 2 5 5 5 0 Domain of unknown function (DUF3336) Pkinase PF00069.25 ETO07886.1 - 2.8e-06 26.9 4.1 0.00067 19.1 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain AP-5_subunit_s1 PF15001.6 ETO07886.1 - 0.00085 19.4 0.8 0.0014 18.6 0.8 1.4 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 Macoilin PF09726.9 ETO07886.1 - 1.6 7.2 26.7 1.9 6.9 26.7 1.1 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 ETO07886.1 - 2.5 6.1 18.3 3 5.9 18.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HTH_Tnp_Tc3_2 PF01498.18 ETO07887.1 - 2.8e-10 40.3 7.1 2.8e-10 40.3 7.1 2.3 2 0 0 2 2 2 1 Transposase HTH_38 PF13936.6 ETO07887.1 - 0.0054 16.5 0.3 0.0054 16.5 0.3 2.2 2 1 0 2 2 2 1 Helix-turn-helix domain HTH_32 PF13565.6 ETO07887.1 - 0.011 16.3 0.4 0.067 13.8 0.3 2.1 1 1 1 2 2 2 0 Homeodomain-like domain DDE_3 PF13358.6 ETO07887.1 - 0.038 13.7 0.0 0.083 12.6 0.0 1.5 1 0 0 1 1 1 0 DDE superfamily endonuclease HTH_Tnp_Tc3_1 PF11427.8 ETO07887.1 - 0.11 12.3 0.7 0.38 10.6 0.1 2.1 2 0 0 2 2 2 0 Tc3 transposase HTH_5 PF01022.20 ETO07887.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family TPR_12 PF13424.6 ETO07888.1 - 2.2e-85 281.0 14.8 2.6e-16 59.7 0.5 9.4 6 2 3 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07888.1 - 9.6e-47 153.4 62.0 5.2e-05 23.0 0.0 14.7 15 0 0 15 15 14 12 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07888.1 - 1.8e-45 151.0 78.5 0.00028 20.6 0.4 16.3 16 0 0 16 16 16 12 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07888.1 - 2.6e-44 145.7 84.9 0.00016 21.6 0.2 15.9 16 0 0 16 16 15 14 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07888.1 - 2.9e-39 130.2 17.2 0.0015 18.4 0.6 12.9 12 0 0 12 12 12 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07888.1 - 4.1e-39 131.4 4.9 0.0031 17.3 0.0 14.0 14 0 0 14 14 14 9 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO07888.1 - 3.1e-14 53.1 0.0 7.9e-07 28.7 0.0 4.3 1 1 2 4 4 4 3 MalT-like TPR region TPR_14 PF13428.6 ETO07888.1 - 1.6e-13 50.2 0.1 3.7 8.6 0.1 10.9 10 2 2 12 12 10 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO07888.1 - 5.5e-13 49.5 2.0 1.1e-12 48.4 2.0 1.5 1 0 0 1 1 1 1 Caspase domain TPR_16 PF13432.6 ETO07888.1 - 1.1e-11 45.2 0.0 1.3 9.7 0.1 8.1 7 2 1 8 8 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO07888.1 - 1.1e-08 35.2 14.1 4.1 8.2 0.1 12.3 14 0 0 14 14 14 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07888.1 - 4.6e-07 29.4 54.1 0.001 18.7 0.1 12.3 14 1 1 15 15 14 4 TPR repeat TPR_17 PF13431.6 ETO07888.1 - 7.7e-07 29.1 19.1 0.23 11.9 0.1 10.8 13 0 0 13 13 11 1 Tetratricopeptide repeat DUF3856 PF12968.7 ETO07888.1 - 0.0022 18.1 9.4 0.16 12.1 0.0 4.9 4 1 1 5 5 5 1 Domain of Unknown Function (DUF3856) DUF5113 PF17140.4 ETO07888.1 - 0.003 17.4 31.5 0.68 9.7 0.1 10.3 9 3 3 12 12 12 2 Domain of unknown function (DUF5113) DUF5588 PF17826.1 ETO07888.1 - 0.0047 15.9 0.2 0.012 14.6 0.2 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5588) Fis1_TPR_C PF14853.6 ETO07888.1 - 0.092 12.8 14.3 1.7 8.8 0.1 5.7 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat DUF357 PF04010.13 ETO07888.1 - 0.5 10.5 18.4 0.51 10.4 0.6 6.2 4 2 2 7 7 6 0 Protein of unknown function (DUF357) TPR_3 PF07720.12 ETO07888.1 - 1.6 8.8 28.4 32 4.6 0.8 9.8 9 1 0 9 9 9 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO07888.1 - 1.6 9.6 18.6 22 5.9 0.0 8.3 10 0 0 10 10 7 0 Sel1 repeat Prefoldin PF02996.17 ETO07888.1 - 2.1 8.3 25.1 0.64 9.9 0.1 6.9 7 1 0 7 7 7 0 Prefoldin subunit Sec34 PF04136.15 ETO07889.1 - 0.004 17.0 5.6 0.18 11.7 0.0 2.4 1 1 0 2 2 2 1 Sec34-like family TMF_TATA_bd PF12325.8 ETO07889.1 - 0.015 15.5 2.6 0.015 15.5 2.6 1.7 2 0 0 2 2 1 0 TATA element modulatory factor 1 TATA binding CAMP_factor PF07373.11 ETO07889.1 - 0.016 14.8 3.4 0.64 9.6 3.5 2.6 1 1 1 2 2 2 0 CAMP factor (Cfa) SYF2 PF08231.12 ETO07889.1 - 0.032 14.7 6.0 0.048 14.1 6.0 1.2 1 0 0 1 1 1 0 SYF2 splicing factor MCPsignal PF00015.21 ETO07889.1 - 0.053 13.3 2.7 0.52 10.1 0.2 2.1 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3037 PF11236.8 ETO07889.1 - 0.098 13.1 1.3 25 5.3 0.2 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF3037) Mod_r PF07200.13 ETO07889.1 - 0.15 12.2 7.7 0.14 12.3 5.0 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CREPT PF16566.5 ETO07889.1 - 0.15 12.2 4.9 0.27 11.4 0.3 2.3 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Mce4_CUP1 PF11887.8 ETO07889.1 - 0.19 11.2 0.5 2.8 7.3 0.0 2.3 2 1 1 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative NPV_P10 PF05531.12 ETO07889.1 - 0.2 12.1 4.8 1.3 9.6 0.2 3.3 1 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein SseC PF04888.12 ETO07889.1 - 0.21 11.1 3.3 3 7.3 0.2 2.2 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family RraB PF06877.11 ETO07889.1 - 0.23 12.2 3.1 3.7 8.3 0.4 2.4 1 1 1 2 2 2 0 Regulator of ribonuclease activity B HR1 PF02185.16 ETO07889.1 - 0.23 11.6 2.2 17 5.7 0.7 2.4 2 0 0 2 2 2 0 Hr1 repeat AI-2E_transport PF01594.16 ETO07889.1 - 0.26 10.4 2.5 7.1 5.7 0.3 2.1 1 1 1 2 2 2 0 AI-2E family transporter ALO PF04030.14 ETO07889.1 - 0.27 11.0 7.6 4 7.2 0.5 2.2 1 1 1 2 2 2 0 D-arabinono-1,4-lactone oxidase PI_PP_I PF18363.1 ETO07889.1 - 0.3 11.3 9.0 0.18 12.0 1.0 2.5 1 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain BLOC1_2 PF10046.9 ETO07889.1 - 0.37 11.1 6.9 1.8 8.9 0.5 3.3 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 ETO07889.1 - 0.46 10.5 8.0 0.48 10.4 4.0 2.5 1 1 2 3 3 3 0 Laminin Domain II DUF948 PF06103.11 ETO07889.1 - 0.5 10.7 4.4 17 5.8 4.4 3.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) ABC1 PF03109.16 ETO07889.1 - 0.7 10.1 3.5 2.7 8.2 0.8 2.3 1 1 1 2 2 2 0 ABC1 family DUF1664 PF07889.12 ETO07889.1 - 0.9 9.6 7.3 0.79 9.8 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF349 PF03993.12 ETO07889.1 - 4.8 7.6 11.1 17 5.8 7.4 3.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) MUG113 PF13455.6 ETO07890.1 - 0.012 16.2 0.2 0.02 15.5 0.2 1.4 1 1 0 1 1 1 0 Meiotically up-regulated gene 113 SPATA1_C PF15743.5 ETO07890.1 - 0.033 14.3 0.1 0.034 14.2 0.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus Kelch_2 PF07646.15 ETO07891.1 - 0.00047 20.0 1.2 1.4 9.1 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO07891.1 - 0.00087 18.8 0.2 2.1 8.0 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO07891.1 - 0.0038 17.2 0.0 10 6.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO07891.1 - 0.054 13.5 0.1 0.74 9.9 0.0 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO07891.1 - 0.11 12.8 0.9 3 8.3 0.0 2.9 3 0 0 3 3 3 0 Kelch motif NADH_dehy_S2_C PF06444.11 ETO07891.1 - 3.1 8.4 5.3 0.41 11.2 0.6 2.0 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus Kelch_4 PF13418.6 ETO07892.1 - 3.1e-05 23.9 0.3 0.00028 20.8 0.1 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO07892.1 - 0.0035 17.6 2.5 3.5 8.0 0.1 4.3 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 ETO07892.1 - 0.02 14.9 4.6 9.5 6.4 0.1 4.9 5 0 0 5 5 5 0 Kelch motif Kelch_1 PF01344.25 ETO07892.1 - 0.25 11.0 1.7 6.5 6.4 0.2 3.3 3 0 0 3 3 3 0 Kelch motif DUF5344 PF17279.2 ETO07893.1 - 0.34 11.5 1.7 7.6 7.2 0.1 3.1 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF4239 PF14023.6 ETO07895.1 - 0.13 12.0 0.6 0.14 11.9 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) Actin PF00022.19 ETO07896.1 - 0.00038 19.2 0.0 0.00053 18.7 0.0 1.3 1 0 0 1 1 1 1 Actin GTP_EFTU PF00009.27 ETO07896.1 - 0.014 14.9 1.1 0.034 13.7 0.9 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain SET PF00856.28 ETO07897.1 - 0.0026 18.2 0.1 0.0071 16.7 0.0 1.7 2 0 0 2 2 2 1 SET domain HSP90 PF00183.18 ETO07898.1 - 4.8e-73 246.8 22.8 8.3e-34 117.4 5.7 4.1 2 1 2 4 4 4 4 Hsp90 protein MFS_1 PF07690.16 ETO07899.1 - 4e-06 26.0 0.9 1.4e-05 24.2 0.8 1.5 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 ETO07900.1 - 2.3e-25 89.3 2.4 2.9e-25 88.9 2.4 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO07900.1 - 0.00025 20.0 13.6 0.059 12.2 14.7 2.1 1 1 0 1 1 1 1 Sugar (and other) transporter TOM13 PF08219.11 ETO07900.1 - 0.39 10.7 2.0 0.41 10.6 0.1 2.0 2 0 0 2 2 2 0 Outer membrane protein TOM13 EF-hand_6 PF13405.6 ETO07902.1 - 2.6e-05 23.8 2.0 0.085 12.8 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO07902.1 - 0.00042 19.6 1.9 0.023 14.2 0.5 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO07902.1 - 0.0014 19.0 2.6 1 9.9 0.9 2.5 1 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO07902.1 - 0.0014 18.4 2.6 0.0097 15.7 0.3 2.9 2 1 1 3 3 3 1 EF-hand domain pair WD40 PF00400.32 ETO07903.1 - 2.9e-07 31.1 1.0 0.00079 20.2 0.1 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat WD40 PF00400.32 ETO07904.1 - 0.003 18.4 8.5 0.1 13.5 0.8 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat TPR_12 PF13424.6 ETO07906.1 - 6.9e-18 64.7 0.2 6.9e-09 35.9 0.0 3.5 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07906.1 - 3.8e-15 54.8 14.8 1.3e-05 25.0 0.3 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07906.1 - 9.4e-14 50.3 8.9 4.1e-05 23.4 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO07906.1 - 1.1e-12 47.0 3.8 7.2e-05 22.6 0.1 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO07906.1 - 2.7e-12 45.9 18.2 1.5e-05 24.6 0.3 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO07906.1 - 2.8e-12 46.1 0.0 0.00015 21.5 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat MIT PF04212.18 ETO07906.1 - 0.00057 19.9 7.4 0.022 14.8 0.1 3.9 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO07906.1 - 0.00061 20.0 3.2 0.14 12.5 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07906.1 - 0.00063 19.4 8.7 0.1 12.3 0.2 3.9 3 1 1 4 4 4 3 TPR repeat TPR_6 PF13174.6 ETO07906.1 - 0.001 19.6 1.4 23 5.9 0.1 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO07906.1 - 0.51 10.4 9.0 0.46 10.5 0.4 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat U-box PF04564.15 ETO07907.1 - 1.1e-08 35.1 0.1 4.5e-08 33.2 0.0 2.1 2 0 0 2 2 2 1 U-box domain zf-NOSIP PF15906.5 ETO07907.1 - 0.006 16.7 1.6 0.1 12.7 0.0 2.8 3 0 0 3 3 3 1 Zinc-finger of nitric oxide synthase-interacting protein DUF3504 PF12012.8 ETO07907.1 - 0.014 15.4 0.7 0.025 14.5 0.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) MIT PF04212.18 ETO07907.1 - 0.041 14.0 1.4 0.12 12.5 1.4 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Cytotoxic PF09000.10 ETO07907.1 - 0.16 12.3 0.3 0.43 10.9 0.3 1.7 1 0 0 1 1 1 0 Cytotoxic DUF2524 PF10732.9 ETO07907.1 - 0.17 12.2 3.6 0.35 11.2 2.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) XkdW PF09636.10 ETO07907.1 - 0.44 10.6 4.9 2.7 8.1 0.3 2.7 1 1 1 2 2 2 0 XkdW protein Muted PF14942.6 ETO07907.1 - 0.83 10.0 15.2 4.7 7.5 7.3 2.3 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein AI-2E_transport PF01594.16 ETO07907.1 - 1.3 8.1 3.9 3.5 6.7 0.1 2.2 2 0 0 2 2 2 0 AI-2E family transporter DUF4200 PF13863.6 ETO07907.1 - 2.2 8.7 17.7 6.6 7.2 17.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Syntaxin-6_N PF09177.11 ETO07907.1 - 3.2 8.4 7.7 3.1 8.4 1.4 2.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal UPF0449 PF15136.6 ETO07907.1 - 3.5 8.2 6.6 2.2 8.8 2.6 2.3 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Kelch_6 PF13964.6 ETO07908.1 - 0.00051 20.2 2.4 0.64 10.4 0.3 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO07908.1 - 0.37 10.4 6.7 19 4.9 1.2 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_3 PF13415.6 ETO07910.1 - 0.043 14.1 0.1 0.12 12.7 0.1 1.8 1 0 0 1 1 1 0 Galactose oxidase, central domain DUF3425 PF11905.8 ETO07911.1 - 0.036 14.1 0.4 0.049 13.6 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3425) DUF4358 PF14270.6 ETO07911.1 - 0.12 12.7 2.1 0.34 11.2 1.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4358) SusD-like_3 PF14322.6 ETO07911.1 - 0.14 12.5 5.1 0.17 12.2 5.1 1.1 1 0 0 1 1 1 0 Starch-binding associating with outer membrane Cation_ATPase PF13246.6 ETO07911.1 - 0.6 10.2 4.3 11 6.2 4.3 2.2 1 1 0 1 1 1 0 Cation transport ATPase (P-type) FAD_binding_4 PF01565.23 ETO07913.1 - 0.00038 20.2 0.1 0.0011 18.7 0.0 1.8 2 1 0 2 2 2 1 FAD binding domain HBS1_N PF08938.10 ETO07913.1 - 0.12 12.7 1.4 0.39 11.1 1.4 1.8 1 0 0 1 1 1 0 HBS1 N-terminus adh_short PF00106.25 ETO07914.1 - 2.8e-16 59.5 3.4 5e-14 52.2 3.4 2.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO07914.1 - 3.2e-10 40.0 0.0 4.4e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Epimerase PF01370.21 ETO07914.1 - 0.0003 20.3 0.1 0.0004 19.9 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family TelA PF05816.11 ETO07914.1 - 0.033 13.2 0.1 0.054 12.6 0.1 1.3 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) PIP49_N PF14875.6 ETO07914.1 - 0.063 13.2 0.2 0.16 11.8 0.0 1.7 2 0 0 2 2 2 0 N-term cysteine-rich ER, FAM69 KR PF08659.10 ETO07914.1 - 0.24 11.3 1.6 7.8 6.4 1.6 2.2 1 1 0 1 1 1 0 KR domain WD40 PF00400.32 ETO07915.1 - 3.2e-33 113.2 27.5 6.6e-07 29.9 0.6 7.7 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07915.1 - 3.1e-11 43.4 0.5 0.086 13.2 0.0 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07915.1 - 1.3e-07 30.7 2.7 0.083 11.5 0.0 4.9 3 2 1 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO07915.1 - 0.00047 19.6 4.1 0.27 10.5 0.1 4.3 3 1 1 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO07916.1 - 5.3e-22 77.7 6.2 2.1e-08 34.7 0.2 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO07916.1 - 5.1e-09 35.3 0.8 0.0022 16.7 0.1 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO07916.1 - 2.9e-06 27.5 0.1 0.55 10.6 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO07916.1 - 0.027 14.3 0.1 3.1 7.6 0.1 2.3 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A AAA_7 PF12775.7 ETO07917.1 - 0.026 14.0 0.0 0.056 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region ASFV_p27 PF06556.11 ETO07917.1 - 0.039 14.0 0.8 0.089 12.9 0.2 1.8 2 0 0 2 2 2 0 IAP-like protein p27 C-terminus AAA_22 PF13401.6 ETO07917.1 - 0.14 12.5 0.0 1.2 9.4 0.0 2.4 3 0 0 3 3 3 0 AAA domain WD40 PF00400.32 ETO07918.1 - 8.2e-13 48.6 4.9 8.4e-06 26.4 0.5 3.1 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07918.1 - 0.047 14.0 0.0 0.87 9.9 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO07919.1 - 5.2e-12 46.1 13.9 4.3e-07 30.5 0.9 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat WD40_like PF17005.5 ETO07919.1 - 7.8e-05 22.1 1.3 0.019 14.3 0.2 2.2 1 1 1 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 ETO07919.1 - 0.00014 22.1 0.0 0.0084 16.4 0.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07919.1 - 0.00016 20.5 2.1 0.0071 15.0 0.3 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Helicase_C PF00271.31 ETO07920.1 - 7.1e-22 77.9 0.0 1.7e-21 76.6 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CATSPERD PF15020.6 ETO07920.1 - 0.11 10.8 0.1 0.15 10.3 0.1 1.1 1 0 0 1 1 1 0 Cation channel sperm-associated protein subunit delta EPL1 PF10513.9 ETO07920.1 - 0.13 12.7 6.6 0.14 12.5 5.1 1.8 1 1 0 1 1 1 0 Enhancer of polycomb-like DAGK_cat PF00781.24 ETO07921.1 - 9.8e-10 38.1 0.0 1.4e-09 37.7 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Presenilin PF01080.17 ETO07921.1 - 0.3 9.8 0.6 0.33 9.7 0.6 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO07921.1 - 0.94 7.8 13.0 1.1 7.5 13.0 1.1 1 0 0 1 1 1 0 Menin Orf78 PF06024.12 ETO07921.1 - 6.2 7.2 8.8 13 6.1 8.8 1.7 1 0 0 1 1 1 0 Orf78 (ac78) RGS PF00615.19 ETO07922.1 - 0.00022 21.5 0.6 0.002 18.4 0.6 2.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain BORCS7 PF16088.5 ETO07922.1 - 0.025 14.8 0.1 1.6 9.1 0.0 2.6 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 7 fn3 PF00041.21 ETO07924.1 - 9.7e-05 22.6 0.3 0.28 11.6 0.1 3.0 2 0 0 2 2 2 2 Fibronectin type III domain M157 PF11624.8 ETO07926.1 - 0.004 16.5 0.7 0.0047 16.3 0.7 1.1 1 0 0 1 1 1 1 MHC class I-like protein M157 N6_N4_Mtase PF01555.18 ETO07927.1 - 0.024 14.3 2.7 0.033 13.9 2.7 1.3 1 0 0 1 1 1 0 DNA methylase AAA_11 PF13086.6 ETO07927.1 - 0.086 12.6 6.6 0.12 12.2 6.6 1.1 1 0 0 1 1 1 0 AAA domain O-antigen_lig PF13425.6 ETO07927.1 - 0.17 10.6 6.6 0.2 10.4 6.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Copine PF07002.16 ETO07930.1 - 4.5e-15 55.7 0.1 9.1e-14 51.4 0.0 2.0 1 1 1 2 2 2 1 Copine Baculo_LEF-11 PF06385.12 ETO07930.1 - 0.033 14.7 0.1 0.066 13.7 0.1 1.6 1 0 0 1 1 1 0 Baculovirus LEF-11 protein WD40 PF00400.32 ETO07931.1 - 3.3e-15 56.2 6.4 2.5e-06 28.1 0.3 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07931.1 - 1.7e-06 27.0 4.8 0.0024 16.6 0.6 2.4 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Glycos_transf_1 PF00534.20 ETO07932.1 - 0.002 17.7 0.1 0.002 17.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl transferases group 1 NACHT PF05729.12 ETO07933.1 - 3.5e-09 36.8 0.1 1.2e-08 35.0 0.0 2.0 1 1 0 1 1 1 1 NACHT domain Sec1 PF00995.23 ETO07934.1 - 5.8e-50 171.1 0.1 7e-50 170.8 0.1 1.0 1 0 0 1 1 1 1 Sec1 family NPR3 PF03666.13 ETO07935.1 - 0.019 13.8 3.9 0.025 13.4 3.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Corona_nucleoca PF00937.18 ETO07935.1 - 0.035 13.2 12.6 0.049 12.7 12.6 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Macoilin PF09726.9 ETO07935.1 - 0.09 11.3 10.8 0.1 11.1 10.8 1.2 1 1 0 1 1 1 0 Macoilin family DUF4094 PF13334.6 ETO07935.1 - 0.28 11.6 0.2 0.28 11.6 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF3523 PF12037.8 ETO07937.1 - 0.0015 18.0 13.6 0.0016 17.9 13.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3523) SIR4_SID PF16991.5 ETO07937.1 - 0.42 10.7 11.2 0.45 10.5 11.2 1.0 1 0 0 1 1 1 0 Sir4 SID domain MFAP1 PF06991.11 ETO07937.1 - 0.91 9.3 20.5 1.2 9.0 20.5 1.1 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing AAA_11 PF13086.6 ETO07937.1 - 3.4 7.4 7.8 4 7.2 7.8 1.1 1 0 0 1 1 1 0 AAA domain DUF5401 PF17380.2 ETO07937.1 - 7.2 4.5 22.5 8.1 4.4 22.5 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Pneumo_M2 PF07380.11 ETO07939.1 - 0.4 11.0 4.1 0.7 10.2 0.1 2.8 3 0 0 3 3 3 0 Pneumovirus M2 protein WD40 PF00400.32 ETO07940.1 - 9.4e-10 38.9 9.4 3.7e-07 30.7 2.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07940.1 - 0.03 14.6 0.0 0.049 13.9 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_7 PF13499.6 ETO07941.1 - 1.8e-10 41.1 0.5 1.4e-05 25.5 0.0 2.2 1 1 2 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO07941.1 - 2.6e-09 35.9 0.7 3.2e-05 23.2 0.0 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO07941.1 - 9.5e-08 31.4 0.9 0.0005 19.8 0.0 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ETO07941.1 - 0.00064 19.5 0.2 0.0099 15.7 0.1 2.7 1 1 2 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO07941.1 - 0.0017 17.7 0.0 0.063 12.8 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_9 PF14658.6 ETO07941.1 - 0.0094 16.3 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain RST PF12174.8 ETO07941.1 - 0.062 13.2 0.0 0.66 9.9 0.0 2.7 2 1 1 3 3 3 0 RCD1-SRO-TAF4 (RST) plant domain Ank_2 PF12796.7 ETO07943.1 - 8.2e-07 29.5 0.1 1.8e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Leu_zip PF15294.6 ETO07943.1 - 0.0021 17.6 0.9 0.0021 17.6 0.9 2.2 2 0 0 2 2 2 1 Leucine zipper Ank_5 PF13857.6 ETO07943.1 - 0.0043 17.3 0.1 0.32 11.4 0.0 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO07943.1 - 0.0094 16.5 0.1 0.019 15.6 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) DUF2205 PF10224.9 ETO07943.1 - 0.074 13.1 0.5 0.22 11.6 0.5 1.8 1 0 0 1 1 1 0 Short coiled-coil protein Trimer_CC PF08954.11 ETO07943.1 - 0.09 12.3 0.1 0.24 11.0 0.1 1.7 1 0 0 1 1 1 0 Trimerisation motif Ank PF00023.30 ETO07943.1 - 0.1 13.1 0.1 0.91 10.1 0.0 2.3 2 0 0 2 2 2 0 Ankyrin repeat TSC22 PF01166.18 ETO07943.1 - 0.12 12.7 0.2 0.12 12.7 0.2 1.8 2 0 0 2 2 2 0 TSC-22/dip/bun family Ank_3 PF13606.6 ETO07943.1 - 0.15 12.7 0.1 28 5.7 0.1 2.6 2 0 0 2 2 2 0 Ankyrin repeat IFP_35_N PF07334.13 ETO07943.1 - 0.21 11.7 0.3 0.21 11.7 0.3 1.9 2 0 0 2 2 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus OMP_b-brl PF13505.6 ETO07943.1 - 0.53 10.4 7.5 0.69 10.0 2.5 2.2 1 1 1 2 2 2 0 Outer membrane protein beta-barrel domain CLZ PF16526.5 ETO07943.1 - 0.87 10.0 4.7 0.33 11.3 0.9 2.3 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels OEP PF02321.18 ETO07943.1 - 3.7 7.3 7.1 0.58 9.9 2.3 2.2 2 1 0 2 2 2 0 Outer membrane efflux protein YabA PF06156.13 ETO07943.1 - 5.7 7.6 7.9 0.33 11.6 0.4 2.7 3 0 0 3 3 3 0 Initiation control protein YabA PHR PF08005.12 ETO07946.1 - 0.032 14.9 0.5 0.069 13.8 0.5 1.6 1 1 0 1 1 1 0 PHR domain ATHILA PF03078.15 ETO07946.1 - 0.062 12.1 0.1 0.069 12.0 0.1 1.0 1 0 0 1 1 1 0 ATHILA ORF-1 family SIS_2 PF13580.6 ETO07946.1 - 0.065 13.3 0.0 0.11 12.5 0.0 1.3 1 1 0 1 1 1 0 SIS domain Tn7_Tnp_TnsA_N PF08722.11 ETO07946.1 - 0.068 13.4 0.0 0.099 12.9 0.0 1.3 1 0 0 1 1 1 0 TnsA endonuclease N terminal Cnd1 PF12717.7 ETO07947.1 - 0.27 11.3 8.1 0.18 11.8 2.1 2.2 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Membralin PF09746.9 ETO07948.1 - 0.84 8.6 4.7 0.91 8.5 4.7 1.0 1 0 0 1 1 1 0 Tumour-associated protein Flavi_NS4B PF01349.17 ETO07950.1 - 0.053 12.9 0.1 0.062 12.7 0.1 1.1 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4B NACHT PF05729.12 ETO07950.1 - 0.053 13.4 0.0 0.077 12.9 0.0 1.3 1 1 0 1 1 1 0 NACHT domain TT_ORF1 PF02956.14 ETO07951.1 - 0.055 12.1 5.8 0.062 12.0 5.8 1.0 1 0 0 1 1 1 0 TT viral orf 1 DUF1003 PF06210.11 ETO07951.1 - 2.2 8.4 7.2 0.61 10.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) DUF2407_C PF13373.6 ETO07951.1 - 4 7.6 6.8 6.2 7.0 6.8 1.3 1 0 0 1 1 1 0 DUF2407 C-terminal domain Menin PF05053.13 ETO07952.1 - 0.12 10.7 8.3 0.13 10.6 8.3 1.0 1 0 0 1 1 1 0 Menin GCR1_C PF12550.8 ETO07954.1 - 0.013 15.8 0.9 0.039 14.3 0.9 1.9 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes RVT_1 PF00078.27 ETO07955.1 - 2e-10 40.5 0.0 0.00021 20.9 0.0 2.7 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Kinesin PF00225.23 ETO07955.1 - 2.9e-10 39.6 0.2 2.9e-10 39.6 0.2 2.1 2 1 0 2 2 2 1 Kinesin motor domain DUF4024 PF13216.6 ETO07958.1 - 3 7.9 6.7 0.34 10.9 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) HSP90 PF00183.18 ETO07960.1 - 1.5e-66 225.3 26.2 2.2e-62 211.6 10.5 3.0 3 0 0 3 3 3 2 Hsp90 protein PHP PF02811.19 ETO07960.1 - 0.11 12.8 1.9 1.3 9.3 0.3 2.5 2 1 0 2 2 2 0 PHP domain Usp PF00582.26 ETO07960.1 - 0.17 12.4 0.1 0.32 11.5 0.1 1.4 1 0 0 1 1 1 0 Universal stress protein family DUF2120 PF09893.9 ETO07960.1 - 7.8 6.6 9.0 0.45 10.6 1.4 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) MCPVI PF02993.14 ETO07962.1 - 0.088 12.6 0.0 0.099 12.5 0.0 1.1 1 0 0 1 1 1 0 Minor capsid protein VI PAP2_C PF14360.6 ETO07963.1 - 7.2e-16 58.5 11.9 7.2e-16 58.5 11.9 3.3 3 1 1 4 4 4 1 PAP2 superfamily C-terminal PAP2 PF01569.21 ETO07963.1 - 5.9e-06 26.1 6.4 5.9e-06 26.1 6.4 2.9 2 1 0 3 3 3 1 PAP2 superfamily DUF4131 PF13567.6 ETO07963.1 - 0.48 10.1 9.4 0.37 10.4 1.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) PAP2_3 PF14378.6 ETO07963.1 - 0.6 9.8 14.2 0.072 12.8 7.7 2.3 2 1 0 2 2 2 0 PAP2 superfamily DUF2721 PF11026.8 ETO07963.1 - 0.72 9.7 0.0 0.72 9.7 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2721) TPR_1 PF00515.28 ETO07964.1 - 4.1e-09 35.9 3.5 0.007 16.1 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO07964.1 - 1.1e-08 34.5 2.1 0.0014 18.5 0.2 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO07964.1 - 2.2e-06 27.8 2.5 1e-05 25.6 2.4 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETO07964.1 - 5.1e-06 26.9 0.2 0.0007 20.2 0.2 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO07964.1 - 7.8e-06 26.1 1.1 0.51 10.7 0.1 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO07964.1 - 5.1e-05 23.7 2.0 0.0002 21.8 0.5 2.5 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO07964.1 - 0.0002 21.3 1.8 0.51 10.7 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO07964.1 - 0.0031 17.1 1.7 1.6 8.4 0.1 3.1 2 1 1 3 3 3 2 TPR repeat Fis1_TPR_C PF14853.6 ETO07964.1 - 0.022 14.9 1.3 0.48 10.5 0.1 3.1 1 1 2 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_6 PF13174.6 ETO07964.1 - 0.037 14.7 6.3 0.52 11.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat RP-C_C PF11800.8 ETO07965.1 - 0.057 13.5 1.4 0.073 13.2 1.4 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region ATPgrasp_YheCD PF14398.6 ETO07965.1 - 0.067 12.4 0.0 0.13 11.4 0.0 1.6 1 1 0 1 1 1 0 YheC/D like ATP-grasp Dicty_REP PF05086.12 ETO07965.1 - 0.11 10.5 5.6 0.12 10.3 5.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hum_adeno_E3A PF05393.11 ETO07965.1 - 0.11 12.4 0.1 0.33 10.9 0.0 1.7 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein ALMT PF11744.8 ETO07965.1 - 0.13 11.0 2.2 0.15 10.9 2.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter SR-25 PF10500.9 ETO07965.1 - 0.77 9.3 26.6 0.27 10.8 10.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein AT_hook PF02178.19 ETO07965.1 - 1.1 9.4 8.1 2.6 8.2 8.1 1.7 1 0 0 1 1 1 0 AT hook motif BUD22 PF09073.10 ETO07970.1 - 0.16 11.2 15.9 0.18 11.1 15.9 1.1 1 0 0 1 1 1 0 BUD22 DUF4820 PF16091.5 ETO07970.1 - 2 7.7 10.9 2.8 7.2 10.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) CDC45 PF02724.14 ETO07970.1 - 3.2 5.9 10.0 3.8 5.7 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO07970.1 - 5.5 7.4 9.6 1.2 9.6 5.9 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 WD40 PF00400.32 ETO07971.1 - 1.7e-16 60.3 18.5 1.6e-07 31.9 1.8 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO07971.1 - 0.0029 16.3 3.5 0.97 8.0 0.2 2.8 2 1 0 3 3 3 2 Nucleoporin Nup120/160 UPF0193 PF05250.11 ETO07972.1 - 0.0087 15.9 2.7 0.0087 15.9 2.7 1.6 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0193) WD40 PF00400.32 ETO07973.1 - 1.4e-114 370.7 51.8 2.7e-09 37.5 0.1 15.2 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07973.1 - 1e-26 93.1 14.7 0.023 15.0 0.1 12.0 1 1 11 13 13 13 9 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO07973.1 - 2.3e-16 60.0 18.2 1.2e-05 24.8 0.2 8.2 3 2 5 9 9 9 5 WD40-like domain Nup160 PF11715.8 ETO07973.1 - 3.4e-15 55.7 25.1 0.66 8.6 0.0 12.1 3 2 7 12 12 12 7 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO07973.1 - 1.6e-12 47.0 4.7 1.1 8.1 0.0 9.5 2 2 9 11 11 11 4 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5046 PF16465.5 ETO07973.1 - 7.4e-09 35.4 0.1 0.021 14.3 0.0 5.1 3 2 2 5 5 5 2 Domain of unknown function (DUF5046) DUF5570 PF17731.1 ETO07973.1 - 4e-05 23.7 14.4 2.9 8.0 0.1 8.2 5 2 4 9 9 9 2 Family of unknown function (DUF5570) Frtz PF11768.8 ETO07973.1 - 6.9e-05 21.4 1.4 1.8 6.8 0.0 4.0 3 1 0 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz Cytochrom_D1 PF02239.16 ETO07973.1 - 0.0014 17.3 8.7 0.77 8.2 0.1 5.2 2 1 2 6 6 6 3 Cytochrome D1 heme domain DUF2436 PF10365.9 ETO07973.1 - 0.0079 16.0 0.0 0.048 13.4 0.0 2.3 2 1 1 3 3 3 1 Domain of unknown function (DUF2436) Lep_receptor_Ig PF06328.11 ETO07973.1 - 0.014 15.3 2.2 2.9 7.9 0.0 4.2 5 0 0 5 5 5 0 Ig-like C2-type domain PD40 PF07676.12 ETO07973.1 - 0.017 15.0 8.9 6.4 6.8 0.1 5.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat POLO_box PF00659.18 ETO07973.1 - 0.038 14.2 12.9 1 9.6 0.0 6.8 8 2 1 9 9 8 0 POLO box duplicated region PT PF04886.12 ETO07974.1 - 0.015 14.8 10.2 0.015 14.8 10.2 2.1 2 0 0 2 2 2 0 PT repeat DUF4672 PF15716.5 ETO07975.1 - 1.2 8.7 9.2 0.79 9.3 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4672) Peptidase_C1_2 PF03051.15 ETO07976.1 - 0.019 13.8 0.4 0.021 13.6 0.4 1.1 1 0 0 1 1 1 0 Peptidase C1-like family Endonuc-dimeris PF09124.10 ETO07976.1 - 5.5 7.2 7.8 31 4.8 4.5 3.1 3 1 0 3 3 3 0 T4 recombination endonuclease VII, dimerisation LRR_6 PF13516.6 ETO07977.1 - 0.00029 20.7 1.3 2.5 8.4 0.1 4.1 4 0 0 4 4 4 2 Leucine Rich repeat FBPase PF00316.20 ETO07977.1 - 0.1 12.0 0.5 0.16 11.4 0.5 1.2 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain Pkinase PF00069.25 ETO07978.1 - 9e-44 149.8 1.8 1e-42 146.4 0.1 3.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO07978.1 - 4.3e-29 101.6 0.0 2.7e-26 92.4 0.0 2.5 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO07978.1 - 0.0018 17.7 0.1 0.0041 16.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TPH PF13868.6 ETO07979.1 - 0.0032 16.0 25.7 0.0032 16.0 25.7 4.0 2 1 2 4 4 4 1 Trichohyalin-plectin-homology domain AKAP7_NLS PF10469.9 ETO07980.1 - 6.2e-22 78.5 0.9 1.4e-21 77.4 0.9 1.6 1 0 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain LigT_PEase PF02834.16 ETO07980.1 - 0.089 13.0 0.1 12 6.1 0.0 2.7 2 0 0 2 2 2 0 LigT like Phosphoesterase PMEI PF04043.15 ETO07981.1 - 0.01 16.2 0.2 0.017 15.5 0.2 1.3 1 0 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor Las1 PF04031.13 ETO07981.1 - 0.09 12.9 0.5 0.22 11.6 0.1 1.8 2 0 0 2 2 2 0 Las1-like NST1 PF13945.6 ETO07982.1 - 1.2 9.3 8.8 0.082 13.0 0.4 2.0 2 0 0 2 2 2 0 Salt tolerance down-regulator Atg14 PF10186.9 ETO07983.1 - 0.011 14.8 7.6 0.019 14.1 7.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Histidinol_dh PF00815.20 ETO07983.1 - 0.024 13.7 4.7 0.041 12.9 4.7 1.3 1 0 0 1 1 1 0 Histidinol dehydrogenase zf-C2H2_aberr PF17017.5 ETO07983.1 - 0.029 14.5 1.2 0.029 14.5 1.2 2.2 1 1 1 2 2 2 0 Aberrant zinc-finger DUF3450 PF11932.8 ETO07983.1 - 0.042 13.1 8.9 0.065 12.5 8.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Ribosomal_L22 PF00237.19 ETO07983.1 - 0.28 11.4 0.1 0.28 11.4 0.1 2.3 2 1 0 2 2 2 0 Ribosomal protein L22p/L17e SKA2 PF16740.5 ETO07983.1 - 0.58 10.0 11.4 4.5 7.1 9.2 2.7 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Laminin_II PF06009.12 ETO07983.1 - 0.59 10.1 10.1 3.8 7.5 7.1 2.3 2 0 0 2 2 2 0 Laminin Domain II TMF_TATA_bd PF12325.8 ETO07983.1 - 1.1 9.5 16.5 10 6.4 14.9 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Tup_N PF08581.10 ETO07983.1 - 1.3 9.4 20.1 0.13 12.5 13.1 2.8 4 0 0 4 4 4 0 Tup N-terminal DUF948 PF06103.11 ETO07983.1 - 1.3 9.3 4.6 0.7 10.2 1.3 2.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF87 PF01935.17 ETO07983.1 - 1.5 8.9 8.2 1 9.4 6.1 1.8 2 0 0 2 2 2 0 Helicase HerA, central domain TMPIT PF07851.13 ETO07983.1 - 4.7 6.4 16.7 11 5.1 15.6 1.9 1 1 1 2 2 2 0 TMPIT-like protein Spectrin PF00435.21 ETO07983.1 - 5.1 7.6 19.3 5.1 7.6 14.4 3.0 2 1 2 4 4 4 0 Spectrin repeat Swi5 PF07061.11 ETO07983.1 - 8.4 6.6 15.3 2.1 8.5 9.0 2.6 1 1 1 2 2 2 0 Swi5 MAPEG PF01124.18 ETO07984.1 - 1.3e-05 25.1 0.0 1.5e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 MAPEG family DUF2208 PF09973.9 ETO07985.1 - 0.01 15.5 0.4 0.013 15.1 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Pkinase PF00069.25 ETO07986.1 - 6.6e-26 91.2 0.0 1e-25 90.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO07986.1 - 1.9e-19 69.9 0.0 2.8e-19 69.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Presenilin PF01080.17 ETO07986.1 - 9.7 4.8 6.3 14 4.3 6.3 1.2 1 0 0 1 1 1 0 Presenilin NACHT PF05729.12 ETO07989.1 - 1.7e-07 31.3 0.0 3.8e-07 30.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO07989.1 - 0.00083 19.8 0.1 0.0047 17.3 0.0 2.0 2 1 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ETO07989.1 - 0.025 13.8 0.0 0.025 13.8 0.0 2.3 1 1 2 3 3 3 0 NB-ARC domain Ndc1_Nup PF09531.10 ETO07989.1 - 0.053 12.2 4.0 0.055 12.2 4.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SMC_N PF02463.19 ETO07989.1 - 0.33 10.3 0.0 0.33 10.3 0.0 2.8 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain V_ATPase_I PF01496.19 ETO07989.1 - 1.8 6.4 10.6 1.9 6.3 10.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RPN2_C PF18004.1 ETO07989.1 - 3.5 7.5 21.5 0.49 10.3 2.2 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Exonuc_VII_L PF02601.15 ETO07989.1 - 5.2 6.5 8.4 6.8 6.2 8.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peroxin-22 PF12827.7 ETO07994.1 - 0.011 15.7 0.3 0.027 14.4 0.2 1.6 1 1 1 2 2 2 0 Peroxisomal biogenesis protein family AAA_9 PF12781.7 ETO07994.1 - 0.019 14.1 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 ATP-binding dynein motor region XAP5 PF04921.14 ETO07994.1 - 0.086 12.7 0.1 0.096 12.5 0.1 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator DASH_Dad1 PF08649.10 ETO07995.1 - 0.42 10.8 4.4 19 5.5 0.1 3.4 3 0 0 3 3 3 0 DASH complex subunit Dad1 Kelch_1 PF01344.25 ETO07996.1 - 4.5e-07 29.3 0.3 0.064 12.9 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO07996.1 - 1.1e-05 25.5 1.2 0.0068 16.7 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO07996.1 - 0.0011 18.9 2.1 1.8 8.7 0.1 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO07996.1 - 0.0018 18.2 0.7 0.13 12.2 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO07996.1 - 0.025 14.9 0.2 9.4 6.7 0.0 3.6 4 0 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO07997.1 - 3.4e-34 116.3 26.5 1.3e-08 35.4 0.1 6.3 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO07997.1 - 3.4e-11 43.3 2.9 0.021 15.1 0.0 4.8 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO07997.1 - 2e-08 33.3 1.5 0.016 13.9 0.3 4.6 3 1 0 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO07997.1 - 0.0058 15.4 6.8 0.57 8.9 4.5 3.3 1 1 0 2 2 2 2 Nup133 N terminal like Mad3_BUB1_II PF08171.11 ETO07997.1 - 0.033 14.4 0.4 0.09 12.9 0.4 1.8 1 0 0 1 1 1 0 Mad3/BUB1 homology region 2 DUF1851 PF08906.11 ETO07998.1 - 0.014 15.3 0.5 0.025 14.5 0.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF1851) AAA PF00004.29 ETO07999.1 - 0.0069 16.8 0.0 0.035 14.5 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) CobA_CobO_BtuR PF02572.15 ETO07999.1 - 0.011 16.1 0.3 0.097 12.9 0.0 2.6 3 0 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_22 PF13401.6 ETO07999.1 - 0.083 13.2 0.3 0.59 10.4 0.1 2.6 3 1 0 3 3 3 0 AAA domain Exo_endo_phos_2 PF14529.6 ETO08000.1 - 3e-13 49.7 0.7 5e-13 49.0 0.7 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO08000.1 - 0.049 13.1 0.0 0.058 12.9 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family DUF4175 PF13779.6 ETO08001.1 - 0.16 9.9 0.2 0.18 9.7 0.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Kelch_6 PF13964.6 ETO08002.1 - 0.021 15.1 0.0 0.54 10.6 0.0 2.5 2 0 0 2 2 2 0 Kelch motif HEAT PF02985.22 ETO08003.1 - 0.0027 17.8 0.0 1.9 9.0 0.0 4.0 3 0 0 3 3 3 1 HEAT repeat HEAT_2 PF13646.6 ETO08003.1 - 0.016 15.6 0.0 0.17 12.3 0.0 2.8 3 0 0 3 3 3 0 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO08003.1 - 0.031 14.8 0.2 0.031 14.8 0.2 6.4 5 1 2 7 7 7 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ETO08003.1 - 0.047 14.2 0.0 7.5 7.2 0.0 3.6 3 0 0 3 3 3 0 HEAT-like repeat BIR PF00653.21 ETO08003.1 - 0.12 13.0 0.3 4.1 8.1 0.1 2.5 2 0 0 2 2 2 0 Inhibitor of Apoptosis domain EF-hand_8 PF13833.6 ETO08003.1 - 0.29 11.0 1.8 29 4.6 0.0 4.7 5 0 0 5 5 5 0 EF-hand domain pair DUF2538 PF10804.8 ETO08006.1 - 0.036 13.8 3.7 0.08 12.7 1.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2538) Exo_endo_phos_2 PF14529.6 ETO08007.1 - 0.51 10.2 6.0 0.66 9.8 0.0 3.0 2 1 1 3 3 3 0 Endonuclease-reverse transcriptase RGS PF00615.19 ETO08008.1 - 1.3e-06 28.6 0.3 2.2e-06 27.9 0.3 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 ETO08009.1 - 0.00021 22.0 1.0 0.0079 17.0 0.6 2.1 2 0 0 2 2 2 2 WD domain, G-beta repeat RVT_1 PF00078.27 ETO08010.1 - 2.8e-26 92.4 7.1 1.7e-15 57.1 1.2 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Kelch_2 PF07646.15 ETO08011.1 - 2.5e-08 33.6 1.0 0.0041 17.0 0.1 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO08011.1 - 8.2e-06 25.9 0.1 1.7 9.1 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO08011.1 - 8.4e-06 25.3 0.1 0.011 15.2 0.0 4.0 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO08011.1 - 0.0002 21.3 0.1 0.087 12.9 0.0 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08011.1 - 0.00021 21.2 2.0 1.1 9.4 0.0 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO08012.1 - 0.15 12.4 0.7 1.7 9.0 0.1 2.6 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO08015.1 - 9.3e-91 295.3 55.3 2.3e-08 34.6 0.0 15.3 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08015.1 - 9.6e-19 67.5 12.5 0.024 14.9 0.2 10.2 1 1 9 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08015.1 - 6.4e-18 64.8 4.4 0.05 12.6 0.0 9.1 1 1 7 9 9 9 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO08015.1 - 3.1e-05 23.5 2.1 0.00018 21.1 1.9 2.2 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO08015.1 - 0.00063 19.9 1.0 0.003 17.7 0.4 2.3 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Spc29 PF17082.5 ETO08015.1 - 0.099 12.5 3.5 1 9.1 0.5 3.9 3 1 1 4 4 4 0 Spindle Pole Component 29 Pentapeptide_3 PF13576.6 ETO08015.1 - 0.15 12.2 2.6 0.9 9.7 2.1 2.4 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO08015.1 - 0.34 10.9 5.4 64 3.6 0.0 6.1 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat VWA_3 PF13768.6 ETO08016.1 - 0.036 14.0 0.0 0.44 10.5 0.0 2.1 1 1 0 1 1 1 0 von Willebrand factor type A domain DUF1330 PF07045.11 ETO08017.1 - 0.086 13.2 0.0 0.45 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) Kelch_1 PF01344.25 ETO08018.1 - 8.4e-06 25.3 4.8 0.0016 18.0 0.8 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO08018.1 - 1.2e-05 25.2 0.1 0.0035 17.3 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO08018.1 - 0.00021 21.1 7.5 4.7 7.3 0.0 5.1 5 2 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ETO08018.1 - 0.0017 18.6 1.7 9.1 6.7 0.0 4.3 4 0 0 4 4 4 1 Kelch motif Copper-bind PF00127.20 ETO08018.1 - 0.06 13.8 0.7 0.16 12.4 0.1 2.0 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family Kelch_5 PF13854.6 ETO08018.1 - 2.5 8.2 6.4 9 6.4 0.0 4.1 6 0 0 6 6 6 0 Kelch motif ABC_tran_Xtn PF12848.7 ETO08022.1 - 0.069 13.2 3.4 0.12 12.4 3.4 1.4 1 0 0 1 1 1 0 ABC transporter HIRAN PF08797.11 ETO08022.1 - 0.14 12.1 0.0 0.57 10.1 0.0 2.0 1 1 0 1 1 1 0 HIRAN domain Potex_coat PF06184.11 ETO08023.1 - 0.08 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 Potexvirus coat protein Histone_HNS PF00816.21 ETO08023.1 - 0.22 12.3 4.7 0.38 11.6 4.2 1.7 1 1 0 1 1 1 0 H-NS histone family DUF3886 PF13025.6 ETO08023.1 - 1.3 9.2 15.0 0.24 11.6 2.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) Myb_DNA-bind_5 PF13873.6 ETO08024.1 - 0.018 15.1 0.8 0.21 11.7 0.1 2.4 2 0 0 2 2 2 0 Myb/SANT-like DNA-binding domain PilJ PF13675.6 ETO08024.1 - 0.1 12.7 0.8 0.52 10.4 0.8 2.2 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term CspB_prodomain PF18425.1 ETO08024.1 - 0.13 12.3 0.2 0.28 11.2 0.2 1.6 1 0 0 1 1 1 0 Csp protease B prodomain Sulfotransfer_1 PF00685.27 ETO08025.1 - 0.0003 20.3 2.1 0.00049 19.7 2.1 1.5 1 1 0 1 1 1 1 Sulfotransferase domain RHD_dimer PF16179.5 ETO08025.1 - 3.2 7.8 8.1 1.6 8.7 0.3 3.1 1 1 2 3 3 3 0 Rel homology dimerisation domain DUF3784 PF12650.7 ETO08026.1 - 0.0015 18.7 5.5 0.0015 18.7 5.5 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF3784) DUF2207 PF09972.9 ETO08026.1 - 0.0067 15.2 2.1 0.009 14.8 2.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Glucos_trans_II PF14264.6 ETO08026.1 - 0.028 13.8 10.1 0.028 13.8 9.2 1.3 1 1 0 1 1 1 0 Glucosyl transferase GtrII Jagunal PF07086.12 ETO08026.1 - 0.31 11.1 4.2 0.32 11.0 3.2 1.6 1 1 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis WD40 PF00400.32 ETO08027.1 - 8.7e-26 89.7 2.7 1.2e-08 35.4 0.3 6.7 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08027.1 - 3.4e-12 46.5 6.1 0.018 15.4 0.0 7.0 3 2 5 8 8 8 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08027.1 - 4.6e-06 25.8 0.1 0.016 14.2 0.0 3.8 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO08027.1 - 0.0023 16.5 0.0 0.19 10.2 0.1 2.9 2 1 1 3 3 3 1 Cytochrome D1 heme domain Kelch_6 PF13964.6 ETO08027.1 - 0.0086 16.3 0.2 0.18 12.2 0.0 3.5 5 0 0 5 5 5 1 Kelch motif DPPIV_N PF00930.21 ETO08027.1 - 0.012 14.4 1.6 3.1 6.5 0.0 3.5 2 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ntox21 PF15526.6 ETO08027.1 - 0.1 12.9 0.2 0.3 11.4 0.2 1.8 1 0 0 1 1 1 0 Novel toxin 21 Kelch_5 PF13854.6 ETO08027.1 - 0.35 10.9 4.7 1.4 8.9 0.1 3.4 4 0 0 4 4 4 0 Kelch motif PD40 PF07676.12 ETO08027.1 - 0.37 10.8 2.0 22 5.2 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat GUB_WAK_bind PF13947.6 ETO08029.1 - 0.087 13.6 1.1 0.14 12.9 0.2 1.7 1 1 1 2 2 2 0 Wall-associated receptor kinase galacturonan-binding AlaDh_PNT_C PF01262.21 ETO08029.1 - 0.2 11.0 0.2 0.33 10.2 0.2 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain TMEM171 PF15471.6 ETO08030.1 - 0.005 15.9 0.5 0.0088 15.1 0.5 1.4 1 0 0 1 1 1 1 Transmembrane protein family 171 Wzy_C PF04932.15 ETO08030.1 - 0.016 14.8 0.3 0.025 14.2 0.3 1.4 1 0 0 1 1 1 0 O-Antigen ligase MutS_V PF00488.21 ETO08030.1 - 0.12 12.4 0.0 0.29 11.1 0.0 1.7 2 0 0 2 2 2 0 MutS domain V DUF3810 PF12725.7 ETO08030.1 - 0.5 9.7 3.6 0.15 11.4 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) Mg_trans_NIPA PF05653.14 ETO08033.1 - 5e-10 39.0 3.8 6.3e-10 38.6 3.8 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA WD40 PF00400.32 ETO08034.1 - 0.032 15.1 1.1 0.052 14.4 0.1 1.9 2 0 0 2 2 2 0 WD domain, G-beta repeat ETRAMP PF09716.10 ETO08034.1 - 1.2 9.2 13.5 0.15 12.1 8.8 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Peptidase_C14 PF00656.22 ETO08035.1 - 8.5e-06 25.9 0.0 1e-05 25.6 0.0 1.1 1 0 0 1 1 1 1 Caspase domain Peptidase_C14 PF00656.22 ETO08036.1 - 0.0005 20.1 0.3 0.00076 19.5 0.3 1.3 1 0 0 1 1 1 1 Caspase domain ELM2 PF01448.24 ETO08037.1 - 1.1 10.1 3.3 14 6.6 0.0 2.5 2 0 0 2 2 2 0 ELM2 domain MSC PF09402.10 ETO08038.1 - 0.026 14.0 1.4 0.031 13.7 1.4 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain TFIIA PF03153.13 ETO08038.1 - 0.042 13.9 12.3 0.046 13.7 12.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4834 PF16118.5 ETO08038.1 - 0.1 13.6 0.3 0.1 13.6 0.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) MadM PF03818.13 ETO08038.1 - 0.19 11.6 0.2 0.28 11.1 0.2 1.2 1 0 0 1 1 1 0 Malonate/sodium symporter MadM subunit FYDLN_acid PF09538.10 ETO08038.1 - 0.41 11.3 21.5 0.053 14.2 15.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Astro_capsid_p PF12226.8 ETO08038.1 - 0.42 9.7 10.9 0.61 9.2 10.9 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Zip PF02535.22 ETO08038.1 - 0.56 9.4 5.5 0.66 9.1 5.5 1.4 1 1 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETO08038.1 - 0.71 9.1 19.8 0.021 14.2 13.3 1.7 2 0 0 2 2 2 0 NOA36 protein Nop14 PF04147.12 ETO08038.1 - 0.98 7.6 22.3 1 7.5 14.6 2.0 2 0 0 2 2 2 0 Nop14-like family Sporozoite_P67 PF05642.11 ETO08038.1 - 1.1 7.3 8.2 1.4 6.9 8.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pox_Ag35 PF03286.14 ETO08038.1 - 1.2 8.9 22.7 0.062 13.1 15.4 2.0 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Connexin PF00029.19 ETO08038.1 - 5.1 6.8 10.4 0.1 12.3 2.6 1.8 1 1 1 2 2 2 0 Connexin Serinc PF03348.15 ETO08038.1 - 5.3 5.8 10.5 3.3 6.5 8.4 1.6 1 1 1 2 2 2 0 Serine incorporator (Serinc) MAP17 PF15807.5 ETO08038.1 - 5.5 7.2 12.3 0.42 10.8 3.4 2.1 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 RXT2_N PF08595.11 ETO08038.1 - 6.6 6.7 20.9 0.3 11.1 13.9 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF2457 PF10446.9 ETO08038.1 - 7 5.7 24.6 0.42 9.7 17.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) DUF2151 PF10221.9 ETO08038.1 - 9.7 4.6 13.8 0.8 8.2 8.1 1.8 2 0 0 2 2 2 0 Cell cycle and development regulator Peptidase_S49_N PF08496.10 ETO08039.1 - 6.3e-05 23.1 4.6 7.2e-05 22.9 4.6 1.0 1 0 0 1 1 1 1 Peptidase family S49 N-terminal ZapB PF06005.12 ETO08039.1 - 0.00068 20.0 17.5 0.079 13.4 7.7 2.2 1 1 1 2 2 2 2 Cell division protein ZapB TMPIT PF07851.13 ETO08039.1 - 0.0019 17.5 12.1 0.0028 16.9 12.1 1.2 1 0 0 1 1 1 1 TMPIT-like protein THOC7 PF05615.13 ETO08039.1 - 0.0024 18.1 14.6 0.0037 17.6 13.5 1.6 1 1 1 2 2 2 1 Tho complex subunit 7 OmpH PF03938.14 ETO08039.1 - 0.0035 17.7 9.9 0.0044 17.4 9.9 1.2 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) HAUS6_N PF14661.6 ETO08039.1 - 0.0039 16.8 7.0 0.0055 16.3 7.0 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 6 N-terminus ZapD PF07072.11 ETO08039.1 - 0.0041 16.9 9.4 0.0063 16.3 8.5 1.6 1 1 1 2 2 2 1 Cell division protein XRN_M PF17846.1 ETO08039.1 - 0.0081 15.2 6.3 0.0098 14.9 6.3 1.0 1 0 0 1 1 1 1 Xrn1 helical domain TPR_MLP1_2 PF07926.12 ETO08039.1 - 0.015 15.4 15.4 0.35 10.9 14.5 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein SID-1_RNA_chan PF13965.6 ETO08039.1 - 0.015 13.7 1.8 0.018 13.5 1.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ATG16 PF08614.11 ETO08039.1 - 0.021 15.1 15.2 0.37 11.0 15.2 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) CdvA PF18822.1 ETO08039.1 - 0.023 14.5 17.0 0.35 10.7 2.8 2.3 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Csm1_N PF18504.1 ETO08039.1 - 0.034 14.5 13.8 0.58 10.5 4.4 2.5 2 1 1 3 3 3 0 Csm1 N-terminal domain Spc7 PF08317.11 ETO08039.1 - 0.052 12.4 19.2 0.073 11.9 17.9 1.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 ETO08039.1 - 0.058 12.9 14.3 0.072 12.6 14.3 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Mod_r PF07200.13 ETO08039.1 - 0.078 13.1 17.1 0.04 14.0 14.2 1.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Phage_GPO PF05929.11 ETO08039.1 - 0.15 11.7 7.1 0.19 11.4 7.1 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4201 PF13870.6 ETO08039.1 - 0.33 10.7 21.1 1.5 8.6 17.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) DUF3810 PF12725.7 ETO08039.1 - 0.45 9.8 6.5 0.69 9.2 6.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Glyco_hydro_67N PF03648.14 ETO08039.1 - 0.54 10.5 3.2 0.5 10.7 0.7 1.8 1 1 1 2 2 2 0 Glycosyl hydrolase family 67 N-terminus SlyX PF04102.12 ETO08039.1 - 0.79 10.4 6.6 11 6.7 0.4 2.7 1 1 2 3 3 3 0 SlyX UPF0242 PF06785.11 ETO08039.1 - 0.8 9.8 20.9 1 9.4 16.7 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ETO08039.1 - 1.2 6.9 9.3 1.4 6.7 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliT PF05400.13 ETO08039.1 - 1.5 9.7 7.5 1.7 9.5 2.7 2.2 1 1 1 2 2 2 0 Flagellar protein FliT YMF19 PF02326.15 ETO08039.1 - 1.6 9.6 15.2 12 6.7 15.2 2.2 1 1 0 1 1 1 0 Plant ATP synthase F0 FapA PF03961.13 ETO08039.1 - 1.7 7.2 14.1 2.3 6.7 14.1 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4337 PF14235.6 ETO08039.1 - 1.9 8.6 15.7 0.2 11.8 5.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) DUF4446 PF14584.6 ETO08039.1 - 1.9 8.5 8.7 0.59 10.1 2.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF1664 PF07889.12 ETO08039.1 - 2.1 8.4 9.0 5.8 7.0 3.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ETO08039.1 - 3.3 7.0 10.6 14 4.9 10.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CENP-H PF05837.12 ETO08039.1 - 3.3 8.2 13.5 5.3 7.5 13.3 1.4 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Mac PF12464.8 ETO08039.1 - 3.6 7.9 7.8 5.6 7.3 1.6 2.6 1 1 1 2 2 2 0 Maltose acetyltransferase YabA PF06156.13 ETO08039.1 - 3.6 8.3 14.3 7.2 7.3 11.0 2.1 1 1 1 2 2 2 0 Initiation control protein YabA DUF724 PF05266.14 ETO08039.1 - 3.8 7.3 19.3 15 5.3 6.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Seryl_tRNA_N PF02403.22 ETO08039.1 - 3.9 7.8 20.2 2.4 8.4 9.0 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 ETO08039.1 - 4 6.4 19.6 29 3.6 19.6 1.8 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 WSD PF15613.6 ETO08039.1 - 4 8.0 9.0 6.5 7.3 9.0 1.4 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif BST2 PF16716.5 ETO08039.1 - 4.3 8.0 17.1 4.2 8.0 4.6 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 GrpE PF01025.19 ETO08039.1 - 5.1 6.7 19.0 0.65 9.6 8.1 2.0 1 1 1 2 2 2 0 GrpE Exonuc_VII_L PF02601.15 ETO08039.1 - 5.4 6.5 11.5 6.3 6.3 11.5 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ax_dynein_light PF10211.9 ETO08039.1 - 6.8 6.6 20.5 4.3 7.2 3.2 2.0 1 1 1 2 2 2 0 Axonemal dynein light chain DUF3552 PF12072.8 ETO08039.1 - 8.4 5.8 20.1 10 5.5 19.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) HSP70 PF00012.20 ETO08039.1 - 8.6 4.4 10.5 9.8 4.2 10.5 1.0 1 0 0 1 1 1 0 Hsp70 protein FWWh PF14922.6 ETO08040.1 - 9.3e-05 22.4 0.9 0.00025 21.0 0.1 2.1 2 1 0 2 2 2 1 Protein of unknown function YlqD PF11068.8 ETO08040.1 - 0.065 13.6 7.7 0.13 12.6 7.7 1.5 1 0 0 1 1 1 0 YlqD protein Exonuc_VII_L PF02601.15 ETO08040.1 - 0.088 12.4 1.2 0.088 12.4 1.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAA_hydro_N_2 PF18288.1 ETO08040.1 - 0.09 13.2 0.0 0.28 11.6 0.0 1.9 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 YlbE PF14003.6 ETO08040.1 - 2.1 8.9 6.9 1.5 9.3 1.3 2.7 2 1 1 3 3 3 0 YlbE-like protein UPAR_LY6_2 PF16975.5 ETO08041.1 - 0.029 14.6 0.6 0.034 14.3 0.6 1.1 1 0 0 1 1 1 0 Ly6/PLAUR domain-containing protein 6, Lypd6 Dimeth_Pyl PF09505.10 ETO08041.1 - 0.086 11.4 0.0 0.095 11.2 0.0 1.2 1 0 0 1 1 1 0 Dimethylamine methyltransferase (Dimeth_PyL) PI_PP_I PF18363.1 ETO08041.1 - 0.15 12.2 1.6 0.3 11.3 1.6 1.7 1 1 0 1 1 1 0 Phosphoinositide phosphatase insertion domain DUF5532 PF17673.1 ETO08041.1 - 0.22 11.6 3.0 0.52 10.4 1.2 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5532) DUF3106 PF11304.8 ETO08043.1 - 0.0015 19.0 1.7 0.0023 18.4 1.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3106) DUF2924 PF11149.8 ETO08043.1 - 0.016 15.6 2.3 0.13 12.7 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2924) DUF2547 PF10818.8 ETO08043.1 - 1.6 9.7 6.1 1.1 10.2 4.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2547) PC_rep PF01851.22 ETO08044.1 - 0.0002 21.7 16.1 0.00021 21.6 0.0 4.2 5 0 0 5 5 5 3 Proteasome/cyclosome repeat RPN1_RPN2_N PF17781.1 ETO08046.1 - 0.0028 17.1 0.6 0.0052 16.2 0.5 1.5 1 1 0 1 1 1 1 RPN1/RPN2 N-terminal domain Salp15 PF12115.8 ETO08046.1 - 0.12 12.9 2.5 0.2 12.1 2.1 1.7 1 1 0 1 1 1 0 Salivary protein of 15kDa inhibits CD4+ T cell activation PRKCSH PF07915.13 ETO08048.1 - 5.6e-13 49.7 1.2 9e-08 33.0 0.1 2.6 2 0 0 2 2 2 2 Glucosidase II beta subunit-like protein DUF5305 PF17231.2 ETO08048.1 - 0.034 13.5 2.8 3.9 6.8 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5305) ArsD PF06953.11 ETO08049.1 - 0.051 13.9 0.8 0.19 12.1 0.0 2.0 2 0 0 2 2 2 0 Arsenical resistance operon trans-acting repressor ArsD DUF5052 PF16475.5 ETO08049.1 - 0.13 11.9 2.8 0.2 11.3 2.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5052) C2-set PF05790.15 ETO08049.1 - 8 6.7 8.3 6.2 7.1 0.9 3.0 1 1 2 3 3 3 0 Immunoglobulin C2-set domain Med3 PF11593.8 ETO08051.1 - 0.12 11.6 4.4 0.13 11.4 4.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4208 PF13907.6 ETO08052.1 - 0.013 15.9 1.2 0.017 15.6 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) Stanniocalcin PF03298.13 ETO08052.1 - 0.085 12.2 2.0 0.13 11.5 1.8 1.5 1 1 0 1 1 1 0 Stanniocalcin family Filo_VP35 PF02097.15 ETO08052.1 - 0.11 11.6 0.0 0.13 11.3 0.0 1.2 1 0 0 1 1 1 0 Filoviridae VP35 UBN_AB PF14075.6 ETO08053.1 - 0.021 14.5 2.2 5.4 6.7 0.5 2.4 2 1 0 2 2 2 0 Ubinuclein conserved middle domain KxDL PF10241.9 ETO08053.1 - 0.53 10.6 3.8 22 5.4 0.1 3.3 3 1 0 3 3 3 0 Uncharacterized conserved protein HSCB_C PF07743.13 ETO08053.1 - 0.74 10.3 4.7 4.8 7.7 0.2 3.7 4 0 0 4 4 4 0 HSCB C-terminal oligomerisation domain WD40 PF00400.32 ETO08055.1 - 1.7e-41 139.4 24.8 2e-07 31.6 0.5 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08055.1 - 4.5e-12 46.1 3.0 0.31 11.4 0.0 5.8 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08055.1 - 1.9e-10 40.0 7.4 0.0014 17.4 1.4 4.8 1 1 4 5 5 5 4 Nucleoporin Nup120/160 SAB PF04382.13 ETO08055.1 - 0.0013 18.7 1.4 0.0013 18.7 1.4 2.4 2 0 0 2 2 2 1 SAB domain ATG16 PF08614.11 ETO08055.1 - 0.049 13.9 20.1 0.66 10.2 2.5 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 ETO08055.1 - 0.074 12.9 12.5 0.18 11.7 1.3 3.5 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TPR_MLP1_2 PF07926.12 ETO08055.1 - 0.13 12.3 27.4 1.4 9.0 12.3 2.6 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO08055.1 - 0.16 11.3 10.9 0.3 10.4 10.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PV-1 PF06637.11 ETO08055.1 - 0.83 8.4 13.8 1.3 7.8 13.8 1.2 1 0 0 1 1 1 0 PV-1 protein (PLVAP) KLRAQ PF10205.9 ETO08055.1 - 1.7 8.9 26.1 1.8 8.9 10.5 2.7 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Fib_alpha PF08702.10 ETO08055.1 - 2.4 8.4 19.7 7.9 6.7 19.7 1.9 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TPD52 PF04201.15 ETO08055.1 - 4.9 6.8 14.8 0.34 10.5 4.4 2.4 1 1 1 2 2 2 0 Tumour protein D52 family DUF641 PF04859.12 ETO08055.1 - 7.2 7.0 15.9 1.6e+02 2.6 15.7 2.7 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) HMMR_N PF15905.5 ETO08055.1 - 9.8 5.5 29.2 19 4.6 29.2 1.5 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal zf-RING_2 PF13639.6 ETO08057.1 - 0.005 17.1 1.1 0.005 17.1 1.1 2.6 2 0 0 2 2 2 1 Ring finger domain GIT_CC PF16559.5 ETO08057.1 - 0.11 12.4 1.4 0.92 9.4 0.3 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Plant_NMP1 PF06694.11 ETO08057.1 - 0.48 9.5 6.1 0.034 13.3 1.3 1.4 2 0 0 2 2 2 0 Plant nuclear matrix protein 1 (NMP1) zf-C3HC4_3 PF13920.6 ETO08057.1 - 3.5 7.6 9.0 1.5 8.7 4.3 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Cation_efflux PF01545.21 ETO08058.1 - 3.2e-06 27.0 11.3 6.1e-06 26.1 11.3 1.5 1 1 0 1 1 1 1 Cation efflux family Apis_Csd PF11671.8 ETO08059.1 - 0.00069 19.7 13.0 0.00069 19.7 13.0 2.7 3 1 1 4 4 4 1 Complementary sex determiner protein CBF PF03914.17 ETO08059.1 - 3 7.9 10.2 1.1e+03 -0.5 10.2 2.8 1 1 0 1 1 1 0 CBF/Mak21 family Proho_convert PF12177.8 ETO08059.1 - 7.8 6.6 5.8 5 7.2 0.2 3.1 3 0 0 3 3 3 0 Prohormone convertase enzyme Comm PF15957.5 ETO08060.1 - 0.0031 17.9 1.3 3 8.2 0.1 2.5 2 0 0 2 2 2 2 Commissureless PDR_CDR PF06422.12 ETO08060.1 - 0.027 14.4 1.5 0.68 9.9 0.0 2.6 2 0 0 2 2 2 0 CDR ABC transporter CitMHS PF03600.16 ETO08060.1 - 0.056 12.6 0.0 0.63 9.2 0.0 2.0 1 1 0 1 1 1 0 Citrate transporter DUF4131 PF13567.6 ETO08060.1 - 0.067 12.8 0.5 2.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) DUF92 PF01940.16 ETO08060.1 - 0.22 10.9 1.5 0.36 10.2 0.7 1.6 2 0 0 2 2 2 0 Integral membrane protein DUF92 PRA1 PF03208.19 ETO08060.1 - 0.36 10.5 3.9 4.9 6.8 0.7 2.2 2 0 0 2 2 2 0 PRA1 family protein AI-2E_transport PF01594.16 ETO08060.1 - 6 5.9 10.7 0.34 10.0 3.6 2.3 2 1 0 2 2 2 0 AI-2E family transporter WD40 PF00400.32 ETO08061.1 - 0.053 14.4 0.2 0.13 13.2 0.2 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat WD40 PF00400.32 ETO08062.1 - 2.3e-08 34.6 2.3 2.5e-08 34.4 0.9 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO08062.1 - 0.0023 16.7 0.1 0.0037 16.0 0.1 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 RNB PF00773.19 ETO08065.1 - 3.2e-97 325.8 0.5 1.6e-96 323.5 0.0 2.0 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 ETO08065.1 - 1.4e-20 73.1 0.4 5.1e-20 71.3 0.0 2.3 2 0 0 2 2 2 1 Dis3-like cold-shock domain 2 (CSD2) CSD2 PF17876.1 ETO08065.1 - 3.5e-09 36.7 2.1 6.9e-05 22.9 0.0 3.5 3 0 0 3 3 3 2 Cold shock domain Rrp44_S1 PF17215.3 ETO08065.1 - 0.013 15.4 0.1 0.033 14.1 0.1 1.7 1 0 0 1 1 1 0 S1 domain PIN_4 PF13638.6 ETO08065.1 - 0.079 13.2 0.3 0.079 13.2 0.3 2.6 2 1 0 2 2 2 0 PIN domain FAM176 PF14851.6 ETO08065.1 - 0.13 11.9 1.6 2.4 7.8 0.3 2.5 2 0 0 2 2 2 0 FAM176 family Dis3l2_C_term PF17877.1 ETO08065.1 - 0.2 12.0 0.1 0.2 12.0 0.1 2.0 2 0 0 2 2 2 0 DIS3-like exonuclease 2 C terminal MatE PF01554.18 ETO08066.1 - 1.4e-20 73.5 28.1 9.4e-17 61.1 7.3 3.7 3 1 1 4 4 4 3 MatE Peroxin-13_N PF04088.13 ETO08066.1 - 0.067 13.5 0.5 0.19 12.0 0.5 1.7 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Tubulin_C PF03953.17 ETO08067.1 - 4.3e-19 68.9 0.1 5.9e-19 68.5 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain LAMTOR5 PF16672.5 ETO08067.1 - 0.12 12.3 0.0 0.19 11.7 0.0 1.3 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 WD40 PF00400.32 ETO08068.1 - 1e-45 152.8 22.7 2.3e-09 37.7 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08068.1 - 3.3e-07 30.5 2.9 0.18 12.1 0.0 4.6 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08068.1 - 5e-07 29.0 0.3 0.012 14.6 0.0 3.2 2 2 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO08068.1 - 7.3e-07 29.3 1.0 0.023 14.6 0.0 3.1 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO08068.1 - 0.00044 19.0 1.0 5.8 5.4 0.0 4.3 4 1 1 5 5 5 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO08069.1 - 9.8e-40 133.8 25.2 2.3e-07 31.4 0.2 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08069.1 - 4.9e-12 46.0 2.2 0.036 14.4 0.0 5.5 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08069.1 - 6.9e-12 44.8 6.4 0.0034 16.1 0.1 5.2 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO08069.1 - 4.1e-05 22.5 6.8 0.0046 15.8 4.5 4.4 1 1 1 2 2 2 2 Nup133 N terminal like WD40_like PF17005.5 ETO08069.1 - 0.00014 21.3 9.3 0.039 13.3 1.1 3.6 1 1 1 3 3 3 2 WD40-like domain DUF4979 PF16351.5 ETO08069.1 - 0.18 12.0 2.3 3.2 7.9 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4979) NinE PF05322.11 ETO08069.1 - 0.2 11.5 2.9 27 4.8 0.0 4.8 6 0 0 6 6 6 0 NINE Protein RabGAP-TBC PF00566.18 ETO08070.1 - 2.7e-49 167.7 2.3 2.7e-49 167.7 2.3 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Ribosomal_L23eN PF03939.13 ETO08070.1 - 1.7 8.9 4.0 13 6.1 1.3 2.9 2 0 0 2 2 2 0 Ribosomal protein L23, N-terminal domain WD40 PF00400.32 ETO08071.1 - 8e-14 51.8 7.4 5.8e-06 26.9 1.0 3.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO08071.1 - 1.4e-05 24.0 2.1 0.0053 15.5 0.2 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO08071.1 - 0.00025 21.7 1.2 0.00025 21.7 1.2 3.1 3 0 0 3 3 3 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO08071.1 - 0.0042 17.3 0.2 0.85 10.0 0.0 2.7 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Gpi1 PF05024.15 ETO08072.1 - 0.015 15.4 0.2 0.036 14.2 0.1 1.7 1 1 0 1 1 1 0 N-acetylglucosaminyl transferase component (Gpi1) UCH PF00443.29 ETO08072.1 - 0.031 13.8 0.5 0.056 12.9 0.4 1.5 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ETO08073.1 - 6.2e-27 93.3 16.7 1.1e-08 35.6 0.4 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO08073.1 - 9.4e-10 37.7 2.6 0.0091 14.7 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08073.1 - 3.3e-09 36.9 1.2 0.04 14.2 0.0 3.0 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08073.1 - 0.00015 21.2 3.3 0.03 13.6 0.7 2.1 1 1 1 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 ETO08073.1 - 0.00031 20.7 0.1 4.8 7.3 0.0 3.1 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region W_rich_C PF07483.11 ETO08073.1 - 0.15 12.2 4.0 0.19 11.9 0.2 2.3 1 1 2 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain Glyco_transf_8 PF01501.20 ETO08074.1 - 0.017 14.7 6.1 0.026 14.1 6.0 1.4 1 1 0 1 1 1 0 Glycosyl transferase family 8 DNA_pol_phi PF04931.13 ETO08075.1 - 5.6 4.9 14.4 7.4 4.5 14.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi Kelch_6 PF13964.6 ETO08078.1 - 0.059 13.7 0.0 0.059 13.7 0.0 3.3 4 1 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ETO08078.1 - 0.12 12.4 0.1 18 5.4 0.1 3.4 2 2 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO08078.1 - 0.15 11.7 2.2 0.55 9.9 0.3 2.8 3 1 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO08079.1 - 1.7e-60 199.5 20.6 1.3e-10 41.7 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08079.1 - 4.7e-24 84.5 1.3 0.0013 19.0 0.0 6.5 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08079.1 - 1.6e-12 47.0 2.9 0.014 14.3 0.0 5.8 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO08079.1 - 2.5e-12 47.1 0.1 6.1e-05 23.0 0.0 4.0 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO08079.1 - 4.7e-11 42.3 8.0 1.6 8.8 0.0 6.6 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO08079.1 - 9.9e-07 28.4 0.1 0.019 14.3 0.0 3.6 2 2 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO08079.1 - 4.2e-05 22.4 1.8 1.1 7.8 0.0 5.2 3 1 3 6 6 6 1 Nucleoporin Nup120/160 VID27 PF08553.10 ETO08079.1 - 0.00024 20.3 0.1 0.14 11.2 0.0 2.3 2 0 0 2 2 2 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ETO08079.1 - 0.0004 19.0 0.3 0.46 9.0 0.1 2.5 1 1 1 2 2 2 2 Cytochrome D1 heme domain DHFR_2 PF06442.11 ETO08079.1 - 0.0018 18.1 0.1 1.1 9.2 0.0 3.1 2 0 0 2 2 2 1 R67 dihydrofolate reductase Resistin PF06954.11 ETO08079.1 - 0.0026 18.3 0.0 0.72 10.4 0.0 3.5 4 0 0 4 4 4 1 Resistin NHL PF01436.21 ETO08079.1 - 0.0028 17.6 0.1 0.15 12.1 0.0 2.8 2 0 0 2 2 2 1 NHL repeat DUF727 PF05303.12 ETO08079.1 - 0.0079 16.2 0.1 7.7 6.6 0.0 3.8 3 1 1 4 4 4 1 Protein of unknown function (DUF727) Peptidase_S9_N PF02897.15 ETO08079.1 - 0.06 12.1 0.1 1.8 7.3 0.0 2.6 2 1 1 3 3 3 0 Prolyl oligopeptidase, N-terminal beta-propeller domain nos_propeller PF18764.1 ETO08079.1 - 0.087 12.7 0.2 22 5.1 0.0 3.9 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat Proteasome_A_N PF10584.9 ETO08079.1 - 2.3 8.0 16.8 5.4 6.8 0.1 5.9 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature TBCC PF07986.12 ETO08081.1 - 1.9e-10 40.5 0.6 7.5e-10 38.6 0.6 2.1 1 0 0 1 1 1 1 Tubulin binding cofactor C TBCC_N PF16752.5 ETO08081.1 - 2.2e-07 31.3 14.2 4.8e-07 30.2 14.2 1.5 1 0 0 1 1 1 1 Tubulin-specific chaperone C N-terminal domain Fzo_mitofusin PF04799.13 ETO08081.1 - 0.019 14.5 4.3 0.019 14.5 4.3 2.2 2 1 0 2 2 2 0 fzo-like conserved region DUF948 PF06103.11 ETO08081.1 - 0.3 11.4 4.5 2.1 8.7 0.5 3.0 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) FAM76 PF16046.5 ETO08081.1 - 1.7 7.9 14.9 0.63 9.3 0.2 2.1 2 0 0 2 2 2 0 FAM76 protein Exonuc_VII_L PF02601.15 ETO08081.1 - 2.1 7.9 9.1 3.5 7.1 9.1 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit BST2 PF16716.5 ETO08081.1 - 3.5 8.3 10.3 12 6.5 5.4 2.5 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF4407 PF14362.6 ETO08081.1 - 5.9 6.1 9.1 9.2 5.5 9.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ubiquitin PF00240.23 ETO08083.1 - 4.9e-11 42.2 0.3 4.9e-11 42.2 0.3 2.5 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.8 ETO08083.1 - 1.2e-05 25.0 0.2 5e-05 23.1 0.2 2.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETO08083.1 - 0.0017 18.3 0.0 0.004 17.1 0.0 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF3972 PF13118.6 ETO08083.1 - 0.0028 18.1 1.8 0.0044 17.4 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3972) UN_NPL4 PF11543.8 ETO08083.1 - 0.0045 17.4 0.0 0.012 16.1 0.0 1.7 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Csm1_N PF18504.1 ETO08083.1 - 0.0054 17.0 0.3 0.0054 17.0 0.3 2.9 3 0 0 3 3 2 1 Csm1 N-terminal domain Syntaxin-6_N PF09177.11 ETO08083.1 - 0.023 15.2 0.5 0.083 13.4 0.5 1.9 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DinB PF05163.12 ETO08083.1 - 0.063 13.2 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 DinB family SlyX PF04102.12 ETO08083.1 - 0.076 13.6 0.6 0.076 13.6 0.6 2.4 2 0 0 2 2 2 0 SlyX DUF4094 PF13334.6 ETO08083.1 - 0.14 12.6 0.4 0.45 11.0 0.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) ABC_tran_CTD PF16326.5 ETO08083.1 - 0.22 11.8 2.6 0.63 10.3 1.1 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain AATF-Che1 PF13339.6 ETO08083.1 - 1.3 9.7 8.1 1.3 9.7 1.0 2.9 3 0 0 3 3 3 0 Apoptosis antagonizing transcription factor Sec2p PF06428.11 ETO08083.1 - 3.5 7.6 7.5 0.12 12.3 0.7 2.1 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p DUF2057 PF09829.9 ETO08083.1 - 4.2 7.5 8.7 3.7 7.7 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2057) GBR_NSP5 PF17580.2 ETO08084.1 - 0.029 14.2 2.8 0.035 13.9 2.8 1.2 1 0 0 1 1 1 0 Group B Rotavirus Non-structural protein 5 DUF4140 PF13600.6 ETO08084.1 - 0.11 13.0 1.7 0.19 12.2 1.7 1.5 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) UPF0242 PF06785.11 ETO08084.1 - 0.66 10.1 7.6 1.1 9.3 7.6 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ETO08084.1 - 2.9 6.9 7.9 3.7 6.5 7.9 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cupin_8 PF13621.6 ETO08085.1 - 6.7e-06 26.0 0.1 3.9e-05 23.5 0.0 2.2 2 1 0 2 2 2 1 Cupin-like domain JmjC PF02373.22 ETO08085.1 - 1.2e-05 25.7 0.0 4e-05 24.0 0.0 1.9 1 0 0 1 1 1 1 JmjC domain, hydroxylase TPR_11 PF13414.6 ETO08085.1 - 0.012 15.2 0.1 0.024 14.3 0.1 1.5 1 0 0 1 1 1 0 TPR repeat TPR_19 PF14559.6 ETO08085.1 - 0.068 13.7 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat MFS_1 PF07690.16 ETO08088.1 - 4.8e-43 147.4 32.7 1.3e-27 96.6 11.8 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO08088.1 - 4.1e-08 32.5 21.5 4e-07 29.3 7.7 3.8 1 1 3 4 4 4 2 Sugar (and other) transporter LacY_symp PF01306.19 ETO08088.1 - 0.026 13.3 9.3 0.026 13.3 4.4 2.1 2 0 0 2 2 2 0 LacY proton/sugar symporter MFS_3 PF05977.13 ETO08088.1 - 0.043 12.2 23.9 0.067 11.6 19.5 2.0 1 1 1 2 2 2 0 Transmembrane secretion effector DUF383 PF04063.14 ETO08089.1 - 0.0093 15.6 0.6 0.013 15.1 0.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF383) EF-hand_7 PF13499.6 ETO08090.1 - 5.2e-12 46.0 8.5 7.4e-08 32.7 2.3 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO08090.1 - 1.4e-10 40.8 7.8 1.4e-06 28.0 0.7 3.2 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO08090.1 - 1.2e-09 37.0 13.2 0.0043 16.5 0.6 5.3 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 ETO08090.1 - 8.5e-07 28.4 9.4 0.0063 16.4 1.1 5.0 5 1 1 6 6 6 2 EF-hand domain EF-hand_4 PF12763.7 ETO08090.1 - 0.00047 20.1 4.1 0.0058 16.6 0.8 2.1 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO08090.1 - 0.0082 16.5 0.9 0.028 14.8 0.3 2.0 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 ETO08090.1 - 0.011 15.7 0.9 3.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Tellurite resistance protein TerB Dockerin_1 PF00404.18 ETO08090.1 - 0.066 13.4 2.9 0.29 11.4 1.7 2.1 2 0 0 2 2 2 0 Dockerin type I domain Mu-like_Pro PF10123.9 ETO08090.1 - 0.099 12.2 0.1 4.3 6.8 0.0 2.0 2 0 0 2 2 2 0 Mu-like prophage I protein EF-hand_5 PF13202.6 ETO08090.1 - 0.13 11.8 19.6 0.21 11.1 0.1 5.1 6 0 0 6 6 6 0 EF hand VPS13 PF16908.5 ETO08090.1 - 0.18 11.5 0.0 2 8.2 0.0 2.0 2 0 0 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal DUF3447 PF11929.8 ETO08095.1 - 0.023 14.7 1.0 0.023 14.7 1.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF3447) DUF3447 PF11929.8 ETO08096.1 - 0.096 12.7 0.5 0.36 10.8 0.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3447) RAI16-like PF10257.9 ETO08098.1 - 0.0047 15.8 0.0 0.0069 15.3 0.0 1.2 1 0 0 1 1 1 1 Retinoic acid induced 16-like protein Pkinase PF00069.25 ETO08099.1 - 3.7e-33 115.0 1.3 1.2e-28 100.3 0.2 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08099.1 - 3.4e-13 49.5 0.1 6.6e-13 48.5 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO08099.1 - 0.022 14.1 0.7 0.085 12.2 0.3 1.9 1 1 1 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4834 PF16118.5 ETO08101.1 - 0.0032 18.4 0.1 0.022 15.7 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) DUF1700 PF08006.11 ETO08101.1 - 0.0037 16.8 3.5 0.0079 15.7 3.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1700) Baculo_11_kDa PF06143.11 ETO08101.1 - 0.01 15.4 0.4 0.024 14.2 0.4 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family CLN3 PF02487.17 ETO08101.1 - 0.021 13.9 0.2 0.031 13.3 0.0 1.4 2 0 0 2 2 2 0 CLN3 protein FSAP_sig_propep PF03032.15 ETO08101.1 - 0.035 14.1 0.1 0.035 14.1 0.1 2.6 1 1 1 2 2 2 0 Frog skin active peptide family signal and propeptide ETRAMP PF09716.10 ETO08101.1 - 0.045 13.8 2.0 0.045 13.8 2.0 2.8 2 1 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) ELFV_dehydrog PF00208.21 ETO08102.1 - 5.4e-23 82.0 0.8 5.9e-23 81.8 0.8 1.0 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase RtcB PF01139.17 ETO08102.1 - 0.073 12.3 0.0 0.073 12.3 0.0 1.0 1 0 0 1 1 1 0 tRNA-splicing ligase RtcB NAD_binding_7 PF13241.6 ETO08104.1 - 0.082 13.3 0.1 0.1 13.0 0.1 1.1 1 0 0 1 1 1 0 Putative NAD(P)-binding VPS9 PF02204.18 ETO08105.1 - 8.4e-11 42.0 0.4 6.7e-07 29.5 0.0 2.2 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain DUF4611 PF15387.6 ETO08105.1 - 0.0032 17.6 0.9 0.0064 16.7 0.9 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4611) WD40 PF00400.32 ETO08107.1 - 1.8e-23 82.4 0.6 7e-09 36.2 0.0 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08107.1 - 1.1e-06 28.8 0.9 0.0003 21.0 0.2 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08107.1 - 3.4e-06 26.0 0.2 0.027 13.1 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08107.1 - 6.8e-06 25.6 2.8 1.2e-05 24.9 2.6 1.5 1 1 0 1 1 1 1 WD40-like domain Nucleoporin_N PF08801.11 ETO08107.1 - 0.0057 15.5 1.7 0.58 8.8 0.3 2.0 1 1 1 2 2 2 2 Nup133 N terminal like Me-amine-dh_H PF06433.11 ETO08107.1 - 0.036 12.9 0.0 0.28 10.0 0.0 1.8 1 1 1 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO08107.1 - 0.054 12.0 0.0 0.068 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain PDDEXK_1 PF12705.7 ETO08107.1 - 0.53 10.1 1.5 18 5.1 0.1 2.1 1 1 1 2 2 2 0 PD-(D/E)XK nuclease superfamily WD40 PF00400.32 ETO08108.1 - 8.7e-37 124.5 36.5 4.7e-07 30.4 0.1 8.2 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08108.1 - 1.6e-09 37.9 1.5 0.063 13.6 0.0 5.7 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08108.1 - 9.2e-08 31.2 6.2 0.56 8.8 0.0 5.6 1 1 5 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08108.1 - 0.0033 16.8 4.3 10 5.4 0.0 4.8 3 2 3 6 6 6 2 WD40-like domain Spc7 PF08317.11 ETO08108.1 - 0.4 9.5 11.8 0.54 9.1 11.8 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF2203 PF09969.9 ETO08108.1 - 7 7.4 7.0 13 6.5 4.2 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) TRAF_BIRC3_bd PF16673.5 ETO08109.1 - 0.00058 19.6 1.3 0.00058 19.6 1.3 2.9 2 1 1 3 3 3 1 TNF receptor-associated factor BIRC3 binding domain DASH_Dam1 PF08653.10 ETO08109.1 - 0.0042 16.8 4.5 0.78 9.6 0.3 3.0 2 0 0 2 2 2 2 DASH complex subunit Dam1 DUF4407 PF14362.6 ETO08109.1 - 0.073 12.4 4.4 0.1 11.9 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4094 PF13334.6 ETO08109.1 - 0.092 13.2 10.9 1.5 9.3 1.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Cytochrom_C_2 PF01322.20 ETO08109.1 - 0.3 12.0 8.0 0.69 10.8 1.4 2.5 1 1 1 2 2 2 0 Cytochrome C' SecA_DEAD PF07517.14 ETO08110.1 - 1.1e-09 38.0 0.4 3.3e-09 36.5 0.0 2.0 2 0 0 2 2 2 1 SecA DEAD-like domain Helicase_C PF00271.31 ETO08110.1 - 0.0015 18.8 2.6 0.013 15.8 0.0 3.6 4 0 0 4 4 4 1 Helicase conserved C-terminal domain UpxZ PF06603.11 ETO08110.1 - 0.0039 17.4 0.2 0.9 9.8 0.0 3.1 3 0 0 3 3 3 1 UpxZ family of transcription anti-terminator antagonists VWA_2 PF13519.6 ETO08110.1 - 0.083 13.6 0.0 0.23 12.1 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain RGS PF00615.19 ETO08111.1 - 0.041 14.1 16.7 0.19 12.0 5.8 3.7 2 2 1 4 4 4 0 Regulator of G protein signaling domain Spectrin PF00435.21 ETO08111.1 - 0.31 11.5 12.5 1.4 9.5 1.4 4.6 4 1 1 5 5 5 0 Spectrin repeat 7TMR-HDED PF07697.11 ETO08111.1 - 1.1 9.3 14.0 1.6e+03 -1.0 14.0 2.6 1 1 0 1 1 1 0 7TM-HD extracellular Phe_tRNA-synt_N PF02912.18 ETO08111.1 - 1.4 8.9 6.2 0.98 9.4 0.1 3.5 4 0 0 4 4 4 0 Aminoacyl tRNA synthetase class II, N-terminal domain Phage_connect_1 PF05135.13 ETO08111.1 - 2.6 8.6 9.9 0.87 10.1 0.2 4.2 4 2 1 5 5 5 0 Phage gp6-like head-tail connector protein Sigma70_ner PF04546.13 ETO08112.1 - 3.7e-05 23.7 10.8 3.7e-05 23.7 10.8 5.8 6 1 1 7 7 7 1 Sigma-70, non-essential region MMR_HSR1 PF01926.23 ETO08112.1 - 4.6e-05 23.5 0.1 0.00041 20.4 0.1 2.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO08112.1 - 0.00043 20.8 0.1 0.00043 20.8 0.1 3.9 2 1 0 2 2 1 1 ABC transporter RsgA_GTPase PF03193.16 ETO08112.1 - 0.0015 18.4 0.5 0.0015 18.4 0.5 3.4 3 1 0 3 3 3 1 RsgA GTPase AAA_19 PF13245.6 ETO08112.1 - 0.0017 18.7 0.1 0.0091 16.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ETO08112.1 - 0.021 14.6 0.0 0.05 13.3 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 ETO08112.1 - 0.022 13.8 0.0 0.055 12.5 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein Zeta_toxin PF06414.12 ETO08112.1 - 0.21 10.8 3.2 0.22 10.8 0.1 2.6 3 0 0 3 3 3 0 Zeta toxin AAA_30 PF13604.6 ETO08112.1 - 0.23 11.1 1.5 0.32 10.7 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ETO08112.1 - 1.6 9.2 4.2 16 5.9 0.0 3.9 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) GxGYxYP_C PF14323.6 ETO08112.1 - 8.2 6.2 7.0 45 3.8 0.1 3.4 3 0 0 3 3 3 0 GxGYxYP putative glycoside hydrolase C-terminal domain PI_PP_I PF18363.1 ETO08112.1 - 9.5 6.5 13.2 11 6.3 0.1 6.9 7 0 0 7 7 7 0 Phosphoinositide phosphatase insertion domain DrsE_2 PF13686.6 ETO08113.1 - 0.031 14.2 0.2 0.033 14.1 0.2 1.0 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family Methyltransf_18 PF12847.7 ETO08113.1 - 0.043 13.7 0.5 2.8 7.8 0.1 2.1 1 1 1 2 2 2 0 Methyltransferase domain YhdB PF14148.6 ETO08115.1 - 0.025 14.7 0.9 0.15 12.2 0.1 2.1 2 0 0 2 2 2 0 YhdB-like protein DUF3574 PF12098.8 ETO08115.1 - 0.052 13.3 0.1 0.095 12.5 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3574) Methyltransf_11 PF08241.12 ETO08116.1 - 1.2e-13 51.5 0.0 2.6e-13 50.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO08116.1 - 2.4e-13 50.6 0.0 9.4e-13 48.7 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO08116.1 - 1.1e-08 35.0 0.2 2.3e-08 34.0 0.2 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO08116.1 - 1.4e-07 32.1 0.6 7.8e-07 29.8 0.0 2.5 3 0 0 3 3 3 1 Methyltransferase domain MetW PF07021.12 ETO08116.1 - 1.6e-06 27.8 0.0 3.2e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 ETO08116.1 - 4.7e-06 26.5 0.1 9.2e-06 25.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 ETO08116.1 - 0.0023 16.9 0.0 0.0044 16.0 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) DUF1869 PF08956.10 ETO08116.1 - 0.069 13.1 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1869) AdoMet_MTase PF07757.13 ETO08116.1 - 0.084 13.2 0.1 0.45 10.9 0.0 2.1 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase UME PF08064.13 ETO08116.1 - 0.12 12.3 0.0 0.74 9.8 0.0 2.3 3 0 0 3 3 3 0 UME (NUC010) domain WRW PF10206.9 ETO08118.1 - 0.15 12.4 1.5 0.62 10.5 0.0 2.3 2 1 1 3 3 3 0 Mitochondrial F1F0-ATP synthase, subunit f NACHT PF05729.12 ETO08121.1 - 2e-16 60.4 0.0 8.3e-16 58.3 0.0 2.2 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO08121.1 - 0.0018 17.5 0.2 0.0055 15.9 0.2 1.8 1 0 0 1 1 1 1 NB-ARC domain HEAT PF02985.22 ETO08121.1 - 0.0027 17.8 3.8 1.9 9.0 0.0 5.9 7 0 0 7 7 7 1 HEAT repeat AAA_16 PF13191.6 ETO08121.1 - 0.011 16.1 0.0 0.031 14.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO08121.1 - 0.012 16.1 0.1 0.15 12.6 0.0 2.5 2 0 0 2 2 2 0 ABC transporter NLRC4_HD2 PF17776.1 ETO08121.1 - 0.014 15.9 7.6 0.017 15.7 0.7 4.0 3 0 0 3 3 3 0 NLRC4 helical domain HD2 HEAT_2 PF13646.6 ETO08121.1 - 0.018 15.4 0.0 1.6 9.2 0.0 2.6 2 0 0 2 2 2 0 HEAT repeats AAA_22 PF13401.6 ETO08121.1 - 0.018 15.3 0.0 0.1 12.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain HEAT_EZ PF13513.6 ETO08121.1 - 0.018 15.5 0.1 4.2 8.0 0.0 3.6 3 0 0 3 3 3 0 HEAT-like repeat AAA_30 PF13604.6 ETO08121.1 - 0.16 11.6 0.0 0.29 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain MA3 PF02847.17 ETO08121.1 - 1.8 8.6 10.9 0.17 11.9 0.9 4.0 4 0 0 4 4 4 0 MA3 domain CEP19 PF14933.6 ETO08122.1 - 1.2 9.5 9.4 0.12 12.7 2.9 2.4 1 1 1 3 3 3 0 CEP19-like protein Rieske_3 PF18465.1 ETO08123.1 - 0.65 10.3 3.3 4.7 7.5 0.1 2.1 2 0 0 2 2 2 0 Rieske 3Fe-4S TPR_1 PF00515.28 ETO08124.1 - 3e-07 30.0 0.8 1.8e-06 27.5 0.1 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO08124.1 - 6.4e-05 23.2 0.0 0.00013 22.2 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO08124.1 - 0.00025 20.8 0.0 0.0081 16.1 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO08124.1 - 0.00028 20.7 0.0 0.00056 19.7 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO08124.1 - 0.00057 19.8 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO08124.1 - 0.001 19.1 1.0 0.0022 18.1 0.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO08124.1 - 0.012 15.2 0.2 0.054 13.2 0.1 2.1 1 1 1 2 2 2 0 TPR repeat RHD_dimer PF16179.5 ETO08124.1 - 0.047 13.7 0.6 0.063 13.3 0.6 1.2 1 0 0 1 1 1 0 Rel homology dimerisation domain CAP_GLY PF01302.25 ETO08125.1 - 5.4e-12 45.5 0.1 1.1e-11 44.6 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain CSRNP_N PF16019.5 ETO08125.1 - 2 8.3 7.2 3.4 7.5 0.2 2.3 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus NIF PF03031.18 ETO08126.1 - 2.3e-27 95.7 0.2 4.1e-27 94.9 0.2 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF4396 PF14342.6 ETO08127.1 - 3.1e-39 134.6 10.9 5.3e-39 133.8 10.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4396) DUF4191 PF13829.6 ETO08127.1 - 1.4 8.2 3.8 5.1 6.4 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) WD40 PF00400.32 ETO08129.1 - 5.3e-09 36.6 2.6 5.2e-06 27.1 0.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO08129.1 - 0.0022 16.7 0.1 0.0028 16.4 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08129.1 - 0.01 16.1 0.0 0.017 15.4 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Pkinase PF00069.25 ETO08131.1 - 0.0038 16.6 1.2 0.026 13.9 1.2 1.9 1 1 0 1 1 1 1 Protein kinase domain CENP-M PF11111.8 ETO08131.1 - 0.051 12.8 1.1 0.12 11.6 0.9 1.7 1 1 1 2 2 2 0 Centromere protein M (CENP-M) AtuA PF07287.11 ETO08132.1 - 0.11 11.2 0.5 0.14 10.9 0.2 1.3 2 0 0 2 2 2 0 Acyclic terpene utilisation family protein AtuA RecQ_Zn_bind PF16124.5 ETO08132.1 - 0.29 11.9 3.9 1.8 9.4 0.5 2.7 2 1 1 3 3 3 0 RecQ zinc-binding FAD_binding_4 PF01565.23 ETO08133.1 - 1.1e-07 31.7 0.0 1.8e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain YajC PF02699.15 ETO08133.1 - 0.01 15.7 0.5 0.027 14.4 0.5 1.8 1 0 0 1 1 1 0 Preprotein translocase subunit PH_3 PF14593.6 ETO08133.1 - 0.04 14.0 0.3 0.087 12.9 0.3 1.5 1 0 0 1 1 1 0 PH domain Copine PF07002.16 ETO08134.1 - 3.2e-34 118.3 0.1 3.4e-28 98.6 0.0 2.1 1 1 1 2 2 2 2 Copine CBP4 PF07960.11 ETO08136.1 - 0.0078 16.1 2.6 0.012 15.4 2.6 1.4 1 0 0 1 1 1 1 CBP4 FMO-like PF00743.19 ETO08138.1 - 1.1e-43 149.4 0.4 1.2e-35 123.0 0.0 2.1 2 0 0 2 2 2 2 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ETO08138.1 - 2.7e-12 46.6 1.1 1.9e-07 30.6 0.2 3.1 2 1 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO08138.1 - 4.2e-12 45.9 0.0 1e-07 31.5 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO08138.1 - 1.6e-08 34.7 0.1 4.9e-08 33.1 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ETO08138.1 - 1e-07 32.4 1.0 0.014 16.0 0.0 3.1 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO08138.1 - 1.1e-07 31.3 0.7 0.0018 17.5 0.0 2.9 3 0 0 3 3 3 2 L-lysine 6-monooxygenase (NADPH-requiring) DAO PF01266.24 ETO08138.1 - 0.0014 18.3 0.4 0.25 10.9 0.0 2.7 2 1 1 3 3 3 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETO08138.1 - 0.0037 16.5 0.5 0.02 14.1 0.1 2.2 3 0 0 3 3 3 1 Thi4 family FAD_binding_2 PF00890.24 ETO08138.1 - 0.0048 16.0 0.0 2.1 7.3 0.0 2.9 3 0 0 3 3 3 1 FAD binding domain GIDA PF01134.22 ETO08138.1 - 0.0098 15.0 0.1 3.5 6.6 0.1 2.3 2 0 0 2 2 2 2 Glucose inhibited division protein A NAD_binding_9 PF13454.6 ETO08138.1 - 0.016 15.2 0.1 2.6 8.0 0.0 2.4 2 0 0 2 2 2 0 FAD-NAD(P)-binding 2-Hacid_dh_C PF02826.19 ETO08138.1 - 0.028 13.8 0.0 0.35 10.2 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAD_binding_3 PF01494.19 ETO08138.1 - 0.035 13.4 0.0 0.12 11.6 0.0 1.7 2 0 0 2 2 2 0 FAD binding domain ThiF PF00899.21 ETO08138.1 - 0.13 11.6 0.0 0.27 10.6 0.0 1.4 1 0 0 1 1 1 0 ThiF family AlaDh_PNT_C PF01262.21 ETO08138.1 - 0.13 11.5 0.1 3.5 6.8 0.0 2.6 3 0 0 3 3 3 0 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 ETO08138.1 - 0.21 10.3 0.1 0.58 8.8 0.0 1.7 2 0 0 2 2 2 0 HI0933-like protein Cyc-maltodext_N PF09087.11 ETO08139.1 - 0.082 13.2 0.5 0.16 12.3 0.5 1.4 1 0 0 1 1 1 0 Cyclomaltodextrinase, N-terminal NAP PF00956.18 ETO08140.1 - 0.0067 15.6 2.0 0.0067 15.6 2.0 2.1 1 1 1 2 2 2 1 Nucleosome assembly protein (NAP) Presenilin PF01080.17 ETO08140.1 - 0.13 11.0 5.1 0.16 10.7 5.1 1.1 1 0 0 1 1 1 0 Presenilin RGS PF00615.19 ETO08141.1 - 5.6e-06 26.6 10.2 0.00028 21.1 10.2 2.1 1 1 0 1 1 1 1 Regulator of G protein signaling domain EntA_Immun PF08951.10 ETO08141.1 - 0.0092 16.3 1.4 0.013 15.8 0.6 1.6 2 0 0 2 2 2 1 Enterocin A Immunity TPK_catalytic PF04263.16 ETO08142.1 - 0.42 10.7 6.2 0.084 12.9 0.5 2.8 2 1 1 3 3 3 0 Thiamin pyrophosphokinase, catalytic domain DUF1501 PF07394.12 ETO08142.1 - 6.4 5.7 9.8 0.7 8.9 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1501) Kinesin PF00225.23 ETO08143.1 - 0.0008 18.4 1.3 0.0011 17.9 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain DUF641 PF04859.12 ETO08143.1 - 0.0074 16.6 5.0 0.0074 16.6 5.0 2.3 2 1 0 2 2 2 1 Plant protein of unknown function (DUF641) ANAPC15 PF15243.6 ETO08143.1 - 0.41 11.1 4.8 1.4 9.3 0.7 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 15 Spore_III_AF PF09581.10 ETO08143.1 - 1.1 9.3 8.7 0.039 14.0 2.2 1.8 2 0 0 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) Fez1 PF06818.15 ETO08143.1 - 1.4 9.3 14.5 0.29 11.6 0.4 2.3 2 1 0 2 2 2 0 Fez1 AAA_23 PF13476.6 ETO08143.1 - 1.7 9.1 16.7 0.42 11.1 3.8 2.1 2 0 0 2 2 2 0 AAA domain Phage_GPO PF05929.11 ETO08143.1 - 2.1 7.9 6.3 1 8.9 1.5 2.0 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Macoilin PF09726.9 ETO08143.1 - 3.9 5.9 12.4 0.048 12.2 2.4 2.1 2 0 0 2 2 2 0 Macoilin family DUF2175 PF09943.9 ETO08143.1 - 4.3 7.7 7.0 27 5.2 1.3 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Atg14 PF10186.9 ETO08143.1 - 5.2 6.1 10.2 5.2 6.0 1.3 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 FapA PF03961.13 ETO08143.1 - 5.5 5.5 11.0 0.93 8.0 2.2 2.0 2 0 0 2 2 2 0 Flagellar Assembly Protein A Sas10 PF09368.10 ETO08144.1 - 0.013 15.9 1.2 0.013 15.9 1.2 2.0 1 1 1 2 2 2 0 Sas10 C-terminal domain DUF3492 PF11997.8 ETO08144.1 - 0.032 14.0 2.8 0.04 13.7 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Presenilin PF01080.17 ETO08144.1 - 0.04 12.7 10.2 0.046 12.5 10.2 1.2 1 0 0 1 1 1 0 Presenilin PepSY_TM PF03929.16 ETO08144.1 - 0.14 11.8 3.0 0.17 11.5 3.0 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Merozoite_SPAM PF07133.11 ETO08144.1 - 0.25 11.3 23.5 0.33 10.9 23.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Sec62 PF03839.16 ETO08144.1 - 1.4 8.4 12.2 2.3 7.7 12.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Neur_chan_memb PF02932.16 ETO08144.1 - 1.5 8.8 9.9 1.9 8.5 9.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO08144.1 - 3.4 5.9 22.4 4.2 5.6 22.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Pannexin_like PF12534.8 ETO08144.1 - 3.4 6.7 9.4 4.6 6.2 9.4 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Ndc1_Nup PF09531.10 ETO08144.1 - 4.2 5.9 9.4 4.9 5.7 9.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF3597 PF12200.8 ETO08144.1 - 4.4 7.9 6.7 7.1 7.2 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3597) LAP1C PF05609.12 ETO08144.1 - 4.9 6.1 14.8 6 5.8 14.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PAT1 PF09770.9 ETO08145.1 - 4.5 5.4 25.3 4.9 5.3 25.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 FYVE PF01363.21 ETO08147.1 - 3.9e-16 58.9 10.1 3.9e-16 58.9 10.1 2.0 2 1 0 2 2 2 1 FYVE zinc finger Sec62 PF03839.16 ETO08147.1 - 0.51 9.8 24.8 0.88 9.0 11.2 2.6 3 0 0 3 3 3 0 Translocation protein Sec62 WD40 PF00400.32 ETO08149.1 - 2.9e-74 243.1 31.7 9.2e-12 45.3 0.2 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08149.1 - 9.8e-38 128.4 1.0 5.5e-05 23.4 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08149.1 - 1.3e-18 67.4 0.4 0.00095 18.6 0.0 5.1 1 1 4 5 5 5 4 WD40-like domain eIF2A PF08662.11 ETO08149.1 - 6e-16 58.9 0.0 9.7e-08 32.1 0.0 3.4 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO08149.1 - 3.6e-13 49.2 0.1 0.11 11.4 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO08149.1 - 5e-11 42.3 2.1 9.1 6.4 0.0 6.6 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO08149.1 - 7.6e-07 28.0 0.6 0.067 11.7 0.1 3.1 1 1 2 3 3 3 2 Cytochrome D1 heme domain Frtz PF11768.8 ETO08149.1 - 8.1e-07 27.7 0.0 1.8 6.8 0.0 4.9 4 1 1 5 5 5 2 WD repeat-containing and planar cell polarity effector protein Fritz PQQ_2 PF13360.6 ETO08149.1 - 8.3e-07 28.8 1.7 0.0018 17.9 0.5 3.3 1 1 1 2 2 2 2 PQQ-like domain Nbas_N PF15492.6 ETO08149.1 - 3.2e-06 26.7 5.8 0.24 10.7 0.1 4.6 1 1 4 5 5 5 3 Neuroblastoma-amplified sequence, N terminal Peptidase_C9 PF01707.16 ETO08149.1 - 2e-05 24.3 0.0 4 7.0 0.0 5.4 1 1 6 7 7 7 1 Peptidase family C9 PQQ PF01011.21 ETO08149.1 - 2.1e-05 24.2 0.0 20 5.3 0.0 6.1 7 0 0 7 7 7 0 PQQ enzyme repeat WXG100 PF06013.12 ETO08149.1 - 0.00018 21.7 0.0 79 3.6 0.0 6.0 7 0 0 7 7 7 0 Proteins of 100 residues with WXG DUF5570 PF17731.1 ETO08149.1 - 0.00021 21.4 12.4 3.6 7.7 0.1 6.2 1 1 6 7 7 7 1 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO08149.1 - 0.00061 19.4 13.3 43 3.9 0.1 8.1 8 0 0 8 8 8 0 Proteasome subunit A N-terminal signature DPPIV_N PF00930.21 ETO08149.1 - 0.00081 18.2 0.4 3.2 6.4 0.0 4.9 1 1 4 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region ArlS_N PF18719.1 ETO08149.1 - 0.0064 16.7 0.0 4.6 7.5 0.0 4.0 1 1 5 6 6 6 1 ArlS sensor domain dsrm PF00035.26 ETO08149.1 - 0.067 13.9 0.3 47 4.8 0.0 4.1 6 0 0 6 6 4 0 Double-stranded RNA binding motif FCP1_C PF09309.10 ETO08149.1 - 0.14 12.1 0.0 1.3e+02 2.2 0.0 4.2 1 1 2 5 5 5 0 FCP1, C-terminal rve PF00665.26 ETO08150.1 - 1.5e-07 31.7 0.0 2.3e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain BAF1_ABF1 PF04684.13 ETO08151.1 - 0.038 13.1 26.2 0.048 12.7 26.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor O-antigen_lig PF13425.6 ETO08151.1 - 0.95 8.2 3.5 1.3 7.8 3.5 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PUF PF00806.19 ETO08152.1 - 3.3e-23 80.0 7.7 1.3e-05 24.6 0.0 7.3 8 0 0 8 8 8 5 Pumilio-family RNA binding repeat CPL PF08144.11 ETO08152.1 - 0.00018 21.9 0.4 0.028 14.8 0.0 3.2 1 1 2 3 3 3 1 CPL (NUC119) domain Clathrin PF00637.20 ETO08152.1 - 0.07 13.0 1.1 0.67 9.8 0.3 2.4 2 0 0 2 2 2 0 Region in Clathrin and VPS WD40 PF00400.32 ETO08155.1 - 1e-31 108.5 23.5 1.5e-06 28.8 0.6 7.3 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08155.1 - 2.2e-12 47.1 1.6 0.019 15.3 0.0 5.4 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08155.1 - 5.8e-07 29.1 7.0 0.042 13.2 0.5 3.8 2 2 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO08155.1 - 1.1e-06 27.7 12.3 0.0079 14.9 1.8 5.0 3 2 1 5 5 5 3 Nucleoporin Nup120/160 DUF2203 PF09969.9 ETO08155.1 - 0.56 10.9 1.9 31 5.3 0.2 3.0 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) DUF5523 PF17661.1 ETO08156.1 - 1.5 8.5 35.8 0.076 12.7 22.2 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5523) WD40 PF00400.32 ETO08157.1 - 3.2e-78 255.6 19.0 3.5e-11 43.4 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO08157.1 - 1.7e-26 93.0 0.1 0.0011 18.0 0.0 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO08157.1 - 2.3e-26 91.9 1.8 0.0028 17.9 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO08157.1 - 9e-12 45.3 0.0 0.0018 18.2 0.0 3.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO08157.1 - 8.6e-11 41.5 7.4 2 8.4 0.1 7.2 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO08157.1 - 2.1e-10 39.9 6.9 0.082 11.5 0.1 5.8 2 1 3 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO08157.1 - 3.7e-07 29.0 0.3 0.00044 18.9 0.1 2.6 1 1 1 3 3 3 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO08157.1 - 3.9e-07 29.7 0.0 0.12 11.7 0.0 3.6 1 1 5 6 6 6 4 WD40-like domain Nbas_N PF15492.6 ETO08157.1 - 6.3e-06 25.7 4.3 3.2 7.0 0.0 5.7 1 1 6 7 7 7 2 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO08157.1 - 2.2e-05 24.0 10.4 3.8 7.3 0.0 7.1 7 0 0 7 7 7 1 Proteasome subunit A N-terminal signature Frtz PF11768.8 ETO08157.1 - 0.00091 17.7 0.0 0.064 11.6 0.0 2.6 1 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETO08157.1 - 0.0026 16.6 4.1 1.3 7.7 0.4 4.0 1 1 4 5 5 5 2 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO08157.1 - 0.0039 16.3 0.2 4.4 6.2 0.0 2.5 1 1 2 3 3 3 3 Coatomer WD associated region DUF4875 PF16175.5 ETO08157.1 - 0.0071 16.5 1.8 8.5 6.5 0.0 4.3 2 2 4 6 6 6 1 Domain of unknown function (DUF4875) Colicin_Ia PF11504.8 ETO08157.1 - 0.1 12.7 0.5 30 4.8 0.0 4.6 5 1 1 6 6 6 0 Colicin Ia Kelch_1 PF01344.25 ETO08158.1 - 0.00011 21.7 1.3 0.00032 20.2 1.3 1.8 1 0 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 ETO08158.1 - 0.00025 21.3 0.4 0.00076 19.7 0.1 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO08158.1 - 0.00061 19.7 4.7 0.0069 16.3 0.5 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO08158.1 - 0.0032 17.4 0.2 0.064 13.3 0.1 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO08158.1 - 0.011 16.0 1.5 1 9.7 0.6 2.8 1 1 1 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO08158.1 - 0.13 12.3 3.6 0.25 11.4 0.7 2.7 3 0 0 3 3 3 0 Kelch motif Synaptobrevin PF00957.21 ETO08159.1 - 0.013 15.3 2.3 0.018 14.8 1.6 1.6 1 1 0 1 1 1 0 Synaptobrevin DUF5064 PF16703.5 ETO08159.1 - 0.018 15.6 0.2 0.036 14.6 0.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF5064) tRNA_NucTran2_2 PF13735.6 ETO08159.1 - 0.068 13.2 6.2 0.1 12.6 5.8 1.5 1 1 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative DUF2607 PF10795.9 ETO08159.1 - 0.07 13.3 1.2 3 8.0 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2607) DUF1664 PF07889.12 ETO08159.1 - 0.19 11.8 2.8 0.28 11.2 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) zf-C3HC4_2 PF13923.6 ETO08159.1 - 0.28 11.1 0.1 0.28 11.1 0.1 2.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) STE2 PF02116.15 ETO08160.1 - 0.019 14.3 0.9 0.027 13.8 0.9 1.2 1 0 0 1 1 1 0 Fungal pheromone mating factor STE2 GPCR Spo7 PF03907.13 ETO08160.1 - 0.29 10.6 6.8 0.48 9.9 6.8 1.7 1 1 0 1 1 1 0 Spo7-like protein WD40 PF00400.32 ETO08161.1 - 2.3e-65 214.9 21.0 6.8e-08 33.0 0.3 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08161.1 - 1.2e-12 47.9 4.0 0.0043 17.3 0.1 6.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO08161.1 - 1.1e-09 38.4 0.0 3.4e-09 36.9 0.0 1.9 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO08161.1 - 8.5e-08 31.7 4.5 1.8e-07 30.6 4.5 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO08161.1 - 0.0001 22.4 0.1 0.00026 21.1 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO08161.1 - 0.0001 21.0 3.2 0.079 11.5 0.4 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO08161.1 - 0.00022 21.3 0.4 0.00051 20.1 0.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) ATPase PF06745.13 ETO08161.1 - 0.0011 18.3 0.3 0.018 14.4 0.0 2.9 3 0 0 3 3 3 1 KaiC AAA_22 PF13401.6 ETO08161.1 - 0.0012 19.1 0.1 0.0098 16.2 0.1 2.5 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO08161.1 - 0.025 15.1 0.7 0.12 12.9 0.0 2.5 3 0 0 3 3 2 0 ABC transporter BSD PF03909.17 ETO08161.1 - 0.026 14.5 0.1 5 7.2 0.0 3.4 2 0 0 2 2 2 0 BSD domain AAA_18 PF13238.6 ETO08161.1 - 0.033 14.7 0.0 0.24 12.0 0.0 2.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO08161.1 - 0.074 13.4 0.0 0.5 10.7 0.0 2.3 1 1 1 2 2 2 0 AAA ATPase domain DUF2120 PF09893.9 ETO08161.1 - 0.13 12.3 1.4 0.52 10.4 0.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) WD40 PF00400.32 ETO08162.1 - 3.4e-20 72.0 4.2 1.1e-09 38.8 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08162.1 - 7.6e-06 26.1 0.0 0.19 12.0 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08162.1 - 0.00021 20.4 0.5 0.11 11.4 0.1 2.5 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO08162.1 - 0.0022 16.7 0.1 0.0055 15.4 0.1 1.6 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO08162.1 - 0.035 13.4 0.3 3.1 7.1 0.1 2.3 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF4265 PF14085.6 ETO08162.1 - 0.12 12.3 0.0 7.6 6.5 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4265) PD40 PF07676.12 ETO08162.1 - 0.77 9.8 4.5 8.8 6.4 0.1 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat XK-related PF09815.9 ETO08163.1 - 0.0022 17.1 6.5 0.0029 16.7 6.5 1.2 1 0 0 1 1 1 1 XK-related protein DUF2207 PF09972.9 ETO08163.1 - 0.012 14.5 2.2 0.014 14.2 2.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) YesK PF14150.6 ETO08163.1 - 0.052 13.7 1.8 0.058 13.6 0.1 2.0 2 0 0 2 2 2 0 YesK-like protein CUE PF02845.16 ETO08165.1 - 0.17 11.6 0.4 0.83 9.4 0.1 2.2 2 0 0 2 2 2 0 CUE domain WD40 PF00400.32 ETO08166.1 - 1.5e-11 44.6 5.0 6.6e-08 33.1 0.4 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08166.1 - 0.00014 22.0 0.1 0.00042 20.6 0.1 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08166.1 - 0.00021 20.1 2.3 0.0008 18.2 2.3 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO08166.1 - 0.0026 17.7 2.0 0.12 12.3 0.3 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Adhesin_E PF16747.5 ETO08166.1 - 0.03 14.4 1.6 0.07 13.2 0.3 2.0 1 1 1 2 2 2 0 Surface-adhesin protein E WD40 PF00400.32 ETO08168.1 - 2.9e-24 84.9 8.3 2.1e-10 41.0 0.1 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08168.1 - 1.4e-09 38.1 0.5 0.00059 20.1 0.0 3.4 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08168.1 - 1.4e-06 27.5 0.9 0.024 13.6 0.0 3.2 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO08168.1 - 1.9e-05 23.4 0.5 0.032 12.8 0.1 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO08168.1 - 0.0087 15.4 0.4 0.012 14.9 0.2 1.5 2 0 0 2 2 2 1 WD40-like domain POLO_box PF00659.18 ETO08168.1 - 0.023 14.9 0.3 1.4 9.2 0.0 2.9 3 1 0 3 3 3 0 POLO box duplicated region PD40 PF07676.12 ETO08168.1 - 0.26 11.3 5.4 34 4.5 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Sel1 PF08238.12 ETO08169.1 - 5.2e-05 23.8 0.6 0.00066 20.3 0.6 2.9 3 0 0 3 3 3 1 Sel1 repeat NFACT-R_1 PF05670.13 ETO08171.1 - 0.0098 16.5 0.0 0.017 15.7 0.0 1.4 1 0 0 1 1 1 1 NFACT protein RNA binding domain Kelch_2 PF07646.15 ETO08172.1 - 8.6e-05 22.4 1.2 0.63 10.1 0.2 4.1 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO08172.1 - 0.00011 22.4 0.5 0.86 10.0 0.1 3.6 3 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO08172.1 - 0.00029 20.4 1.8 0.0029 17.1 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO08172.1 - 0.073 13.4 0.0 0.89 9.9 0.0 2.7 2 0 0 2 2 2 0 Galactose oxidase, central domain PH_11 PF15413.6 ETO08173.1 - 0.00012 22.5 0.1 0.00012 22.5 0.1 2.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ETO08173.1 - 0.00019 21.9 1.3 0.001 19.5 0.2 2.7 2 1 0 2 2 2 1 PH domain Zip PF02535.22 ETO08174.1 - 1.2 8.3 6.6 1.2 8.2 6.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 ETO08174.1 - 1.6 7.2 9.4 1.8 7.0 9.4 1.0 1 0 0 1 1 1 0 Macoilin family SelP_N PF04592.14 ETO08174.1 - 3.1 7.2 15.7 4.5 6.6 15.7 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Glyco_hydro_38C PF07748.13 ETO08175.1 - 3.5e-16 59.9 0.0 5.3e-16 59.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain DUF2661 PF10860.8 ETO08176.1 - 0.0025 17.9 2.7 0.0034 17.5 2.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2661) Clr5 PF14420.6 ETO08177.1 - 0.06 13.6 1.6 0.37 11.0 0.1 2.7 3 0 0 3 3 3 0 Clr5 domain PUB PF09409.10 ETO08177.1 - 0.21 11.5 5.0 0.34 10.9 0.7 2.8 2 1 0 2 2 2 0 PUB domain Pyr_redox_2 PF07992.14 ETO08178.1 - 3.4e-05 23.2 0.0 3.4e-05 23.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ETO08178.1 - 0.00057 18.4 0.0 0.00057 18.4 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Shikimate_DH PF01488.20 ETO08178.1 - 0.002 18.2 0.0 0.0027 17.8 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Pyr_redox PF00070.27 ETO08178.1 - 0.0027 18.2 0.0 0.0047 17.5 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO08178.1 - 0.0061 15.9 0.0 0.0077 15.5 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO08178.1 - 0.024 13.8 0.0 0.028 13.6 0.0 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Oxidored_nitro PF00148.19 ETO08178.1 - 0.047 12.4 0.0 0.051 12.3 0.0 1.2 1 0 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase 2-Hacid_dh_C PF02826.19 ETO08178.1 - 0.13 11.6 0.0 0.15 11.5 0.0 1.1 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain FAM76 PF16046.5 ETO08179.1 - 0.24 10.7 26.5 0.07 12.5 9.8 2.3 2 0 0 2 2 2 0 FAM76 protein Symplekin_C PF12295.8 ETO08180.1 - 5e-36 124.5 0.5 5e-36 124.5 0.5 1.8 2 0 0 2 2 2 1 Symplekin tight junction protein C terminal MID_MedPIWI PF18296.1 ETO08180.1 - 0.00054 19.8 4.9 0.00076 19.3 4.9 1.2 1 0 0 1 1 1 1 MID domain of medPIWI INO80_Ies4 PF08193.11 ETO08180.1 - 0.015 15.3 5.0 0.018 15.0 5.0 1.1 1 0 0 1 1 1 0 INO80 complex subunit Ies4 TLP-20 PF06088.11 ETO08180.1 - 0.15 12.0 2.6 0.23 11.3 2.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RabGAP-TBC PF00566.18 ETO08181.1 - 1.8e-14 53.9 2.6 2.6e-14 53.4 2.6 1.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain BSMAP PF12280.8 ETO08181.1 - 0.00031 21.0 0.1 0.00036 20.8 0.1 1.2 1 0 0 1 1 1 1 Brain specific membrane anchored protein eIF3_p135 PF12807.7 ETO08181.1 - 0.15 12.1 1.5 0.21 11.6 1.5 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Cytomega_UL84 PF06284.11 ETO08181.1 - 0.21 10.0 6.0 0.27 9.7 6.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Ribosomal_60s PF00428.19 ETO08181.1 - 0.8 10.3 8.1 1.3 9.6 8.1 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF3464 PF11947.8 ETO08181.1 - 0.96 9.2 2.8 1.6 8.5 2.8 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TERB2 PF15101.6 ETO08181.1 - 1.4 8.9 6.8 2.2 8.3 6.5 1.3 1 1 0 1 1 1 0 Telomere-associated protein TERB2 Glyco_hydro_3_C PF01915.22 ETO08183.1 - 1.5e-14 54.4 0.0 1.8e-14 54.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain TMCO5 PF14992.6 ETO08184.1 - 0.0035 17.0 0.2 0.0035 17.0 0.2 1.5 2 0 0 2 2 2 1 TMCO5 family 7TM_GPCR_Srh PF10318.9 ETO08184.1 - 0.32 10.0 10.9 0.57 9.2 10.9 1.3 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srh Orf78 PF06024.12 ETO08184.1 - 4.4 7.7 6.9 0.2 11.9 0.7 2.0 3 0 0 3 3 3 0 Orf78 (ac78) SLC35F PF06027.12 ETO08185.1 - 3e-15 56.5 8.8 3.7e-15 56.2 8.8 1.1 1 0 0 1 1 1 1 Solute carrier family 35 EamA PF00892.20 ETO08185.1 - 0.069 13.3 6.6 0.097 12.8 6.6 1.2 1 0 0 1 1 1 0 EamA-like transporter family RhoGEF PF00621.20 ETO08186.1 - 1.4e-16 61.3 0.2 1.9e-16 60.9 0.2 1.2 1 0 0 1 1 1 1 RhoGEF domain NOA36 PF06524.12 ETO08187.1 - 0.00021 20.7 2.9 0.00025 20.5 2.9 1.0 1 0 0 1 1 1 1 NOA36 protein CytadhesinP1 PF12378.8 ETO08187.1 - 4.5 7.5 8.9 15 5.8 7.3 2.0 1 1 1 2 2 2 0 Trypsin-sensitive surface-exposed protein DUF913 PF06025.12 ETO08188.1 - 0.0023 17.0 0.5 0.0088 15.1 0.2 2.0 1 1 1 2 2 2 1 Domain of Unknown Function (DUF913) Ribosomal_S19 PF00203.21 ETO08189.1 - 2.3e-23 81.9 0.5 3.1e-23 81.5 0.5 1.1 1 0 0 1 1 1 1 Ribosomal protein S19 Nop14 PF04147.12 ETO08190.1 - 2.4 6.2 95.0 2.5 6.2 41.0 2.2 2 0 0 2 2 2 0 Nop14-like family SH3_1 PF00018.28 ETO08192.1 - 5.2e-30 102.8 4.4 1.8e-14 53.0 0.2 2.4 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ETO08192.1 - 1.8e-22 78.8 0.3 3.2e-12 45.9 0.0 2.4 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 ETO08192.1 - 9.7e-22 76.6 1.7 3.2e-10 39.7 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain VHP PF02209.19 ETO08192.1 - 5e-16 58.5 1.0 5e-16 58.5 1.0 2.0 2 0 0 2 2 2 1 Villin headpiece domain FYVE PF01363.21 ETO08192.1 - 4.4e-07 29.9 13.0 0.00015 21.8 13.3 2.4 1 1 0 1 1 1 1 FYVE zinc finger Sec20 PF03908.13 ETO08192.1 - 0.33 10.9 1.1 0.87 9.6 1.1 1.7 1 0 0 1 1 1 0 Sec20 PH_13 PF16652.5 ETO08193.1 - 7.9e-06 25.8 7.8 0.017 14.9 3.6 2.1 1 1 1 2 2 2 2 Pleckstrin homology domain PH PF00169.29 ETO08193.1 - 1.6e-05 25.4 0.6 3.1e-05 24.4 0.6 1.5 1 0 0 1 1 1 1 PH domain PH_16 PF17838.1 ETO08193.1 - 0.0052 16.6 0.3 1 9.2 0.1 2.2 2 0 0 2 2 2 2 PH domain RhoGEF PF00621.20 ETO08194.1 - 7.1e-15 55.7 1.6 9.5e-15 55.3 1.6 1.2 1 0 0 1 1 1 1 RhoGEF domain SUIM_assoc PF16619.5 ETO08195.1 - 0.00074 19.5 0.3 0.00084 19.4 0.3 1.3 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 TMEM208_SND2 PF05620.11 ETO08195.1 - 0.0087 15.9 1.6 0.0087 15.9 1.6 2.1 2 1 0 2 2 2 1 SRP-independent targeting protein 2/TMEM208 Sbt_1 PF05982.12 ETO08196.1 - 0.0018 17.6 0.1 0.009 15.3 0.0 1.9 2 0 0 2 2 2 1 Na+-dependent bicarbonate transporter superfamily PBP1_TM PF14812.6 ETO08197.1 - 1.8 9.0 7.2 0.46 10.9 3.0 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNase_H PF00075.24 ETO08198.1 - 3.8e-08 33.6 0.0 4.2e-08 33.5 0.0 1.1 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETO08198.1 - 0.015 15.1 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase-like CAS_CSE1 PF03378.15 ETO08199.1 - 7.1e-21 74.2 1.2 1.3e-12 46.9 0.0 2.1 1 1 1 2 2 2 2 CAS/CSE protein, C-terminus PIRT PF15099.6 ETO08199.1 - 0.074 12.6 1.0 0.17 11.5 0.3 1.8 1 1 1 2 2 2 0 Phosphoinositide-interacting protein family Vta1 PF04652.16 ETO08199.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Vta1 like CAS_CSE1 PF03378.15 ETO08200.1 - 1.8e-50 171.8 5.4 1.8e-50 171.8 5.4 1.9 2 0 0 2 2 2 1 CAS/CSE protein, C-terminus Cse1 PF08506.10 ETO08200.1 - 7.8e-47 159.9 0.4 7.8e-47 159.9 0.4 1.8 2 0 0 2 2 2 1 Cse1 DUF3385 PF11865.8 ETO08200.1 - 0.015 15.2 3.8 2.8 7.8 0.1 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF3385) Nop52 PF05997.12 ETO08200.1 - 0.019 14.8 0.7 0.053 13.3 0.3 2.1 2 0 0 2 2 2 0 Nucleolar protein,Nop52 DUF2420 PF10336.9 ETO08200.1 - 0.28 11.2 4.5 4.7 7.3 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2420) Xpo1 PF08389.12 ETO08200.1 - 0.3 11.2 5.0 28 4.7 0.1 4.2 3 1 1 5 5 5 0 Exportin 1-like protein WD40 PF00400.32 ETO08201.1 - 5.8e-64 210.5 18.2 2.7e-10 40.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08201.1 - 1.4e-20 73.3 3.2 0.0021 18.3 0.1 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08201.1 - 2e-14 53.3 0.5 0.071 12.1 0.0 6.2 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO08201.1 - 4.6e-11 43.0 0.2 0.0027 17.6 0.0 3.4 1 1 4 5 5 5 4 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO08201.1 - 9.6e-08 31.7 0.7 0.013 14.8 0.0 2.8 2 2 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO08201.1 - 1.2e-06 27.3 0.4 0.024 13.2 0.0 2.2 2 0 0 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO08201.1 - 4.4e-05 23.6 0.5 1.2 9.2 0.1 4.9 2 2 3 5 5 5 1 Family of unknown function (DUF5570) Nup160 PF11715.8 ETO08201.1 - 5.3e-05 22.1 7.0 2 6.9 0.1 5.1 2 2 2 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO08201.1 - 0.0059 16.5 6.6 12 6.0 0.1 5.1 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Me-amine-dh_H PF06433.11 ETO08201.1 - 0.0087 15.0 0.1 0.54 9.1 0.0 2.7 1 1 2 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) DUF2963 PF11178.8 ETO08201.1 - 0.0096 15.6 2.1 30 4.4 0.0 4.5 4 1 1 5 5 5 0 Protein of unknown function (DUF2963) Nucleoporin_N PF08801.11 ETO08201.1 - 0.05 12.3 5.5 12 4.5 0.1 3.9 1 1 2 4 4 4 0 Nup133 N terminal like WD40 PF00400.32 ETO08202.1 - 2.4e-64 211.7 21.6 3e-09 37.4 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08202.1 - 1.6e-23 82.8 5.6 0.00021 21.5 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08202.1 - 2.6e-18 66.1 1.9 0.023 13.7 0.0 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO08202.1 - 3.3e-07 30.0 1.3 0.12 11.7 0.1 3.9 1 1 4 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO08202.1 - 4.8e-07 28.8 11.3 0.83 8.2 0.1 6.4 1 1 6 7 7 7 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO08202.1 - 0.00012 20.8 5.5 0.11 11.0 0.1 3.2 1 1 2 3 3 3 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO08202.1 - 0.00074 19.6 8.1 14 5.8 0.0 5.1 1 1 3 5 5 5 0 Family of unknown function (DUF5570) Ricin_B_lectin PF00652.22 ETO08202.1 - 0.0029 17.9 3.7 0.048 13.9 0.2 2.8 2 1 0 3 3 3 1 Ricin-type beta-trefoil lectin domain Frtz PF11768.8 ETO08202.1 - 0.0053 15.1 0.1 1.5 7.1 0.0 2.8 2 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Arena_ncap_C PF17290.2 ETO08202.1 - 0.0089 15.4 0.1 2.8 7.2 0.0 3.1 2 1 1 3 3 3 1 Arenavirus nucleocapsid C-terminal domain DUF2415 PF10313.9 ETO08202.1 - 0.014 15.3 0.1 1.7 8.6 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) PD40 PF07676.12 ETO08202.1 - 0.028 14.4 14.0 34 4.5 0.1 6.7 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat DUF4988 PF16378.5 ETO08202.1 - 0.031 13.9 0.6 24 4.5 0.0 3.7 2 2 2 4 4 4 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO08202.1 - 0.081 12.6 5.6 9.6 6.0 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature TRAM_LAG1_CLN8 PF03798.16 ETO08204.1 - 3.4e-23 82.4 24.9 3.4e-23 82.4 24.9 1.5 2 0 0 2 2 2 1 TLC domain EIIC-GAT PF03611.14 ETO08204.1 - 0.015 14.4 4.4 0.011 14.8 3.3 1.3 1 1 0 1 1 1 0 PTS system sugar-specific permease component WD40 PF00400.32 ETO08206.1 - 6.3e-82 267.4 35.7 3.4e-09 37.2 0.4 11.1 10 1 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08206.1 - 7.4e-27 93.5 4.7 0.01 16.1 0.1 9.4 1 1 9 10 10 10 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08206.1 - 4.2e-20 72.0 1.7 0.0092 15.0 0.1 8.9 2 1 8 10 10 10 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO08206.1 - 1.3e-08 34.6 0.1 1.2 8.4 0.0 5.2 4 2 2 6 6 6 4 WD40-like domain NACHT PF05729.12 ETO08206.1 - 1.1e-07 32.0 0.0 2.2e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO08206.1 - 3.6e-06 26.5 5.8 8.6e-06 25.3 5.8 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO08206.1 - 2.5e-05 24.1 0.5 10 6.2 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO08206.1 - 0.00033 20.8 0.1 0.0009 19.4 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO08206.1 - 0.0011 19.3 0.0 0.0077 16.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO08206.1 - 0.0011 19.5 2.6 0.0021 18.6 0.0 2.8 3 1 1 4 4 2 1 AAA domain Gmad1 PF10647.9 ETO08206.1 - 0.0029 17.4 2.8 0.068 12.9 1.3 2.9 2 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain Pentapeptide_3 PF13576.6 ETO08206.1 - 0.023 14.9 1.0 0.091 12.9 1.0 2.1 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO08206.1 - 0.031 12.8 0.2 16 3.9 0.0 3.2 2 1 1 4 4 4 0 Cytochrome D1 heme domain NB-ARC PF00931.22 ETO08206.1 - 0.062 12.5 1.1 0.24 10.5 0.1 2.4 2 1 0 2 2 2 0 NB-ARC domain AAA PF00004.29 ETO08206.1 - 0.063 13.7 0.1 0.33 11.4 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF1797 PF08796.10 ETO08206.1 - 0.082 13.0 0.0 24 5.1 0.0 4.6 3 2 2 5 5 5 0 Protein of unknown function (DUF1797) WD40 PF00400.32 ETO08207.1 - 1e-23 83.1 3.7 1.4e-09 38.4 0.0 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO08207.1 - 3.7e-07 29.4 0.0 0.018 14.0 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO08207.1 - 5.7e-07 29.7 0.1 0.0023 18.2 0.1 3.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08207.1 - 1.6e-05 24.4 0.0 0.016 14.5 0.0 2.0 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO08207.1 - 0.00013 20.8 1.0 0.87 8.1 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO08207.1 - 0.0026 17.7 0.0 2.9 7.9 0.0 2.3 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO08207.1 - 0.023 13.2 0.0 0.03 12.8 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO08207.1 - 0.026 14.6 0.3 1.4 9.1 0.0 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO08207.1 - 0.058 12.4 0.0 0.14 11.2 0.0 1.5 1 1 1 2 2 2 0 Coatomer WD associated region DPPIV_N PF00930.21 ETO08207.1 - 0.08 11.7 0.0 5.5 5.7 0.0 2.0 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETO08207.1 - 0.59 9.9 1.7 13 5.6 0.2 2.5 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Clathrin_lg_ch PF01086.17 ETO08208.1 - 9.3e-13 48.8 21.1 2.6e-12 47.3 21.1 1.5 1 1 0 1 1 1 1 Clathrin light chain Ripply PF14998.6 ETO08208.1 - 2 9.1 11.4 3.2 8.4 3.2 2.9 2 1 1 3 3 3 0 Transcription Regulator TFIIA PF03153.13 ETO08210.1 - 0.0021 18.1 16.6 0.0021 18.1 16.6 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 ETO08210.1 - 0.0036 16.1 9.1 0.0036 16.1 9.1 2.9 3 0 0 3 3 3 1 Presenilin DUF4853 PF16145.5 ETO08210.1 - 0.047 13.8 0.2 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4853) MRI PF15325.6 ETO08210.1 - 2.3 9.3 9.3 1.8 9.7 3.3 2.9 3 0 0 3 3 3 0 Modulator of retrovirus infection Striatin PF08232.12 ETO08211.1 - 0.013 16.1 7.6 0.022 15.4 7.6 1.3 1 0 0 1 1 1 0 Striatin family RGS PF00615.19 ETO08211.1 - 0.21 11.9 5.4 0.52 10.6 5.4 1.8 1 1 0 1 1 1 0 Regulator of G protein signaling domain Presenilin PF01080.17 ETO08211.1 - 0.42 9.3 9.5 0.56 8.9 9.5 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO08211.1 - 0.45 9.5 12.1 0.56 9.2 12.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Macoilin PF09726.9 ETO08211.1 - 0.47 9.0 13.3 0.57 8.7 13.3 1.1 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO08211.1 - 0.74 8.1 9.0 0.92 7.8 9.0 1.1 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO08211.1 - 1.5 7.6 10.4 1.9 7.2 10.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PT PF04886.12 ETO08212.1 - 8.6e-05 22.0 13.7 8.6e-05 22.0 13.7 2.1 2 0 0 2 2 2 1 PT repeat Kelch_6 PF13964.6 ETO08212.1 - 0.058 13.7 4.2 2.3 8.6 0.0 3.5 4 0 0 4 4 4 0 Kelch motif DUF4106 PF13388.6 ETO08212.1 - 1.2 8.3 3.4 1.8 7.7 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) ORC6 PF05460.13 ETO08214.1 - 0.0058 16.0 0.2 0.024 13.9 0.0 1.7 1 1 1 2 2 2 1 Origin recognition complex subunit 6 (ORC6) RGS PF00615.19 ETO08215.1 - 0.00037 20.8 0.1 0.00056 20.2 0.1 1.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain Haemocyan_bet_s PF14830.6 ETO08215.1 - 0.0091 16.0 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 Haemocyanin beta-sandwich ERM PF00769.19 ETO08216.1 - 0.25 11.1 37.2 0.51 10.1 37.2 1.5 1 0 0 1 1 1 0 Ezrin/radixin/moesin family CALCOCO1 PF07888.11 ETO08216.1 - 5.4 5.8 38.4 13 4.5 38.3 1.6 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Hydrolase_4 PF12146.8 ETO08217.1 - 0.014 14.6 0.0 0.44 9.8 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETO08217.1 - 0.048 13.1 0.0 0.28 10.6 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family BAAT_C PF08840.11 ETO08217.1 - 0.089 12.7 0.1 0.53 10.2 0.0 2.0 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal ATG16 PF08614.11 ETO08218.1 - 0.0026 18.0 9.3 0.0026 18.0 9.3 6.5 2 1 3 6 6 6 4 Autophagy protein 16 (ATG16) KASH_CCD PF14662.6 ETO08218.1 - 0.0031 17.3 15.2 0.0031 17.3 15.2 6.2 2 1 4 6 6 6 2 Coiled-coil region of CCDC155 or KASH DWNN PF08783.11 ETO08218.1 - 1.3 9.3 5.9 1.2 9.4 2.2 2.9 2 0 0 2 2 2 0 DWNN domain kleA_kleC PF17383.2 ETO08218.1 - 7 7.1 14.9 3 8.2 0.2 4.7 3 2 2 5 5 5 0 Uncharacterized KorC regulated protein A DUF2514 PF10721.9 ETO08220.1 - 0.062 13.3 1.1 0.069 13.2 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Ac76 PF05814.11 ETO08221.1 - 0.047 13.7 1.2 0.12 12.3 1.2 1.7 1 0 0 1 1 1 0 Orf76 (Ac76) RhoGEF PF00621.20 ETO08223.1 - 1.1e-29 104.0 2.2 1.9e-29 103.2 2.2 1.4 1 0 0 1 1 1 1 RhoGEF domain Stealth_CR3 PF17102.5 ETO08223.1 - 0.0027 17.5 0.1 0.0051 16.7 0.1 1.4 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 CDC45 PF02724.14 ETO08224.1 - 0.34 9.1 5.8 0.5 8.6 5.8 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM163 PF15069.6 ETO08224.1 - 1.3 9.4 4.0 0.68 10.4 1.3 1.8 2 0 0 2 2 2 0 FAM163 family IMUP PF15761.5 ETO08224.1 - 2.3 8.9 7.0 8.3 7.2 0.9 2.4 2 1 0 2 2 2 0 Immortalisation up-regulated protein BUD22 PF09073.10 ETO08224.1 - 5.5 6.2 13.9 7.4 5.8 13.9 1.1 1 0 0 1 1 1 0 BUD22 Pox_RNA_Pol_19 PF05320.12 ETO08224.1 - 8 6.4 8.3 0.78 9.7 3.6 1.6 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Vac14_Fab1_bd PF12755.7 ETO08225.1 - 1.7e-20 73.4 7.2 2.4e-20 72.9 1.9 3.6 3 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ETO08225.1 - 7.1e-08 32.1 5.4 0.0038 17.4 0.0 5.6 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ETO08225.1 - 1.1e-06 28.9 0.1 0.18 12.2 0.0 4.2 2 1 1 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ETO08225.1 - 4.3e-05 23.9 0.2 0.004 17.6 0.0 4.0 4 0 0 4 4 4 1 HEAT-like repeat RasGEF_N_2 PF14663.6 ETO08225.1 - 0.00029 21.2 4.3 0.076 13.4 0.2 3.9 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain CLASP_N PF12348.8 ETO08225.1 - 0.00096 18.8 6.9 0.47 10.0 0.1 5.0 3 1 3 6 6 6 3 CLASP N terminal UME PF08064.13 ETO08225.1 - 0.0089 15.9 0.7 0.08 12.9 0.3 2.7 2 0 0 2 2 2 1 UME (NUC010) domain OSTMP1 PF09777.9 ETO08225.1 - 0.014 14.8 0.5 0.028 13.8 0.5 1.5 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor Yae1_N PF09811.9 ETO08226.1 - 0.00037 20.1 15.7 0.078 12.7 0.0 5.9 4 4 1 5 5 5 3 Essential protein Yae1, N terminal Dynein_light PF01221.18 ETO08231.1 - 4.4e-05 23.7 0.1 6.3e-05 23.2 0.1 1.3 1 1 0 1 1 1 1 Dynein light chain type 1 TGS PF02824.21 ETO08232.1 - 2.4e-23 82.0 0.1 2.8e-23 81.7 0.1 1.1 1 0 0 1 1 1 1 TGS domain CENP-F_leu_zip PF10473.9 ETO08233.1 - 0.00087 19.3 4.3 0.00087 19.3 4.3 12.3 3 2 9 12 12 12 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_N PF15905.5 ETO08233.1 - 0.0022 17.6 41.3 0.0022 17.6 41.3 7.6 2 2 4 6 6 6 1 Hyaluronan mediated motility receptor N-terminal DUF4164 PF13747.6 ETO08233.1 - 0.016 15.5 0.3 0.016 15.5 0.3 11.8 6 3 6 13 13 13 0 Domain of unknown function (DUF4164) DUF1192 PF06698.11 ETO08233.1 - 0.15 12.2 0.1 0.15 12.2 0.1 7.7 11 1 0 11 11 11 0 Protein of unknown function (DUF1192) WD40 PF00400.32 ETO08234.1 - 1.5e-34 117.4 16.5 1.2e-05 26.0 0.4 7.2 6 3 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08234.1 - 2e-10 40.8 0.2 0.0045 17.3 0.0 4.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08234.1 - 1.3e-09 37.3 2.1 0.078 11.6 0.0 4.5 3 1 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08234.1 - 0.003 16.9 4.8 0.69 9.2 0.0 4.2 3 1 1 5 5 5 2 WD40-like domain Pkinase PF00069.25 ETO08236.1 - 3.9e-06 26.4 0.0 4.6e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO08237.1 - 5.2e-12 45.7 0.7 9.4e-11 41.6 0.1 2.9 2 2 1 3 3 3 1 Protein kinase domain HSBP1 PF06825.12 ETO08237.1 - 0.029 14.2 0.8 0.076 12.9 0.8 1.8 1 1 0 1 1 1 0 Heat shock factor binding protein 1 RIO1 PF01163.22 ETO08237.1 - 0.036 13.7 0.0 0.036 13.7 0.0 3.2 3 1 1 4 4 4 0 RIO1 family YojJ PF10372.9 ETO08237.1 - 0.17 12.0 3.1 0.54 10.4 3.1 1.8 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus DUF848 PF05852.11 ETO08237.1 - 0.37 10.9 6.7 0.42 10.7 2.6 2.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) CarboxypepD_reg PF13620.6 ETO08238.1 - 1.9e-10 40.9 0.0 1.2e-08 35.1 0.0 2.7 2 1 0 2 2 2 1 Carboxypeptidase regulatory-like domain SdrD_B PF17210.3 ETO08238.1 - 1.1e-05 25.6 0.4 0.00013 22.2 0.0 2.4 3 0 0 3 3 3 1 SdrD B-like domain CarbopepD_reg_2 PF13715.6 ETO08238.1 - 0.00032 20.6 0.1 0.0026 17.7 0.0 2.6 2 0 0 2 2 2 1 CarboxypepD_reg-like domain Big_1 PF02369.16 ETO08238.1 - 0.00048 20.1 0.8 6.2 6.9 0.0 3.6 3 0 0 3 3 3 1 Bacterial Ig-like domain (group 1) Y_Y_Y PF07495.13 ETO08238.1 - 0.00064 19.6 0.0 0.0016 18.3 0.0 1.6 1 0 0 1 1 1 1 Y_Y_Y domain Dioxygenase_C PF00775.21 ETO08238.1 - 0.0034 16.9 0.2 0.11 11.9 0.0 2.9 2 1 0 3 3 3 1 Dioxygenase SpaA PF17802.1 ETO08238.1 - 0.062 13.6 0.1 0.34 11.3 0.0 2.3 2 1 0 2 2 2 0 Prealbumin-like fold domain Mit_KHE1 PF10173.9 ETO08238.1 - 1.5 8.9 10.5 2.5 8.2 10.5 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related DUF4407 PF14362.6 ETO08238.1 - 7.1 5.9 14.8 11 5.2 14.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HAT PF02184.16 ETO08239.1 - 5.1e-15 55.1 27.7 0.00031 20.6 0.1 7.0 7 0 0 7 7 7 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ETO08239.1 - 0.00016 22.2 6.4 0.29 12.1 0.0 5.4 6 2 2 8 8 8 2 Tetratricopeptide repeat Suf PF05843.14 ETO08239.1 - 0.0046 17.0 2.4 0.0046 17.0 2.4 4.0 3 2 1 5 5 5 1 Suppressor of forked protein (Suf) TPR_9 PF13371.6 ETO08239.1 - 0.0058 16.8 1.8 0.57 10.4 0.4 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO08239.1 - 0.01 16.3 0.1 19 5.9 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat U3_assoc_6 PF08640.11 ETO08239.1 - 0.054 13.6 16.0 0.35 11.0 0.8 4.7 3 2 2 5 5 5 0 U3 small nucleolar RNA-associated protein 6 DUF3899 PF13038.6 ETO08239.1 - 0.17 12.4 2.7 13 6.3 0.1 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) TPR_6 PF13174.6 ETO08239.1 - 2.6 8.9 6.2 53 4.8 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ETO08239.1 - 2.8 8.0 18.5 0.26 11.3 1.0 5.0 3 2 1 4 4 4 0 Mad3/BUB1 homology region 1 NRDE-2 PF08424.10 ETO08239.1 - 3.1 6.8 19.5 1.9 7.5 1.4 4.0 2 2 1 4 4 4 0 NRDE-2, necessary for RNA interference WD40 PF00400.32 ETO08240.1 - 6.9e-17 61.5 3.9 2.1e-05 25.2 0.4 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08240.1 - 0.00039 20.6 0.2 1.3 9.4 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08240.1 - 0.00061 18.6 0.5 0.62 8.6 0.0 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO08241.1 - 2.5e-37 126.2 23.1 6.3e-07 30.0 0.8 7.8 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO08241.1 - 9.7e-12 44.3 8.1 0.013 14.2 0.4 5.2 3 1 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08241.1 - 1.3e-11 44.6 1.5 0.03 14.6 0.0 6.2 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO08241.1 - 0.00015 22.4 1.6 0.00071 20.2 0.9 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger zf-C3HC4_3 PF13920.6 ETO08241.1 - 1.2 9.0 4.3 3.6 7.5 2.7 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) BBS2_Mid PF14783.6 ETO08241.1 - 1.3 9.1 6.1 85 3.2 0.0 5.5 6 1 0 6 6 6 0 Ciliary BBSome complex subunit 2, middle region BrnT_toxin PF04365.13 ETO08242.1 - 0.061 13.7 0.1 0.14 12.6 0.1 1.6 1 0 0 1 1 1 0 Ribonuclease toxin, BrnT, of type II toxin-antitoxin system TPR_19 PF14559.6 ETO08243.1 - 7.5e-08 32.8 0.1 0.0038 17.7 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_4 PF07721.14 ETO08243.1 - 0.011 16.2 0.0 12 6.8 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO08243.1 - 0.03 15.1 0.1 1 10.4 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO08243.1 - 0.053 13.7 4.4 0.6 10.4 3.8 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 GEMIN8 PF15348.6 ETO08243.1 - 0.18 12.1 22.5 0.062 13.6 10.3 2.4 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Folliculin PF11704.8 ETO08243.1 - 4.9 7.0 12.6 0.45 10.4 6.5 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Thioredoxin PF00085.20 ETO08244.1 - 5.1e-23 81.0 0.4 1.3e-22 79.7 0.4 1.7 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ETO08244.1 - 0.00073 19.8 2.8 0.041 14.2 0.0 4.2 3 2 0 3 3 3 1 Thioredoxin-like TraF PF13728.6 ETO08244.1 - 0.0088 15.9 0.0 0.052 13.4 0.0 2.1 2 0 0 2 2 2 1 F plasmid transfer operon protein Thioredoxin_3 PF13192.6 ETO08244.1 - 0.053 13.6 0.0 0.11 12.6 0.0 1.4 1 0 0 1 1 1 0 Thioredoxin domain Thioredoxin_2 PF13098.6 ETO08244.1 - 0.17 12.3 0.5 3.3 8.2 0.3 2.8 2 1 0 2 2 2 0 Thioredoxin-like domain EF-hand_1 PF00036.32 ETO08245.1 - 5.6e-09 34.9 6.8 0.0026 17.2 0.0 4.1 4 1 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO08245.1 - 5.7e-09 36.3 7.3 0.015 15.8 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO08245.1 - 3.1e-08 32.9 6.2 0.031 14.2 0.1 4.1 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 ETO08245.1 - 0.00054 19.3 2.5 0.39 10.3 0.0 3.7 4 0 0 4 4 4 2 EF hand CENP-R PF06729.12 ETO08245.1 - 0.017 15.0 1.9 0.04 13.8 1.9 1.6 1 0 0 1 1 1 0 Kinetochore component, CENP-R EF-hand_8 PF13833.6 ETO08245.1 - 0.028 14.2 3.9 2.9 7.8 0.1 3.5 3 1 1 4 4 4 0 EF-hand domain pair DUF4199 PF13858.6 ETO08245.1 - 0.24 11.8 0.4 0.49 10.8 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF3306 PF11748.8 ETO08245.1 - 0.32 11.9 6.4 0.58 11.0 6.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) DDRGK PF09756.9 ETO08245.1 - 0.37 10.4 15.2 3.2 7.3 14.0 2.4 2 1 0 2 2 2 0 DDRGK domain Presenilin PF01080.17 ETO08245.1 - 0.41 9.4 1.3 0.46 9.2 1.3 1.1 1 0 0 1 1 1 0 Presenilin PX PF00787.24 ETO08245.1 - 0.85 9.6 6.0 0.55 10.2 1.6 2.9 2 1 0 2 2 2 0 PX domain UCH PF00443.29 ETO08246.1 - 0.0047 16.5 4.1 0.032 13.7 0.0 2.2 1 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Herpes_TK_C PF08465.10 ETO08247.1 - 0.12 12.1 0.5 0.29 10.9 0.2 1.8 2 0 0 2 2 2 0 Thymidine kinase from Herpesvirus C-terminal DUF2956 PF11169.8 ETO08247.1 - 0.68 10.2 3.5 2.4 8.4 3.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) FlgT_M PF16539.5 ETO08249.1 - 0.01 16.0 1.7 1.3 9.1 0.4 2.3 2 1 0 2 2 2 0 Flagellar assembly protein T, middle domain DUF5596 PF18082.1 ETO08249.1 - 0.011 15.5 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5596) ATG16 PF08614.11 ETO08249.1 - 0.065 13.5 1.7 0.11 12.8 1.7 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Tetraspanin PF00335.20 ETO08249.1 - 0.15 11.7 5.7 0.031 14.0 2.3 1.7 2 0 0 2 2 2 0 Tetraspanin family Kelch_6 PF13964.6 ETO08251.1 - 8.9e-06 25.8 0.9 0.49 10.8 0.0 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO08251.1 - 0.00085 18.9 0.1 0.033 13.8 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO08251.1 - 0.00099 19.1 2.4 0.17 11.9 0.1 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF3439 PF11921.8 ETO08252.1 - 0.022 14.7 10.2 0.055 13.4 10.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) PrgH PF09480.10 ETO08252.1 - 0.052 12.9 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 Type III secretion system protein PrgH-EprH (PrgH) Mucin PF01456.17 ETO08252.1 - 0.2 11.7 17.7 0.36 10.8 17.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein AJAP1_PANP_C PF15298.6 ETO08252.1 - 0.36 11.0 8.9 0.75 10.0 8.9 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus FSA_C PF10479.9 ETO08252.1 - 0.69 8.0 4.3 0.95 7.5 4.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 ETO08252.1 - 0.87 7.7 15.2 1.2 7.3 15.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 ETO08252.1 - 1.1 7.2 11.0 0.035 12.1 5.0 1.5 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein MGC-24 PF05283.11 ETO08252.1 - 6.4 7.2 13.8 0.74 10.3 9.4 1.6 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Methyltransf_16 PF10294.9 ETO08253.1 - 0.069 12.9 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Lysine methyltransferase SDA1 PF05285.12 ETO08253.1 - 5.6 6.3 25.1 1.1 8.6 17.5 2.2 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ETO08254.1 - 0.009 14.3 6.0 0.01 14.1 6.0 1.2 1 0 0 1 1 1 1 Nop14-like family Sporozoite_P67 PF05642.11 ETO08254.1 - 0.022 12.8 12.7 0.034 12.2 12.7 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SDA1 PF05285.12 ETO08254.1 - 0.027 13.9 7.5 0.039 13.4 7.5 1.3 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 ETO08254.1 - 0.18 10.9 17.4 0.31 10.1 17.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4637 PF15470.6 ETO08254.1 - 0.55 9.9 3.8 1.5 8.6 3.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) FAM176 PF14851.6 ETO08254.1 - 1.8 8.2 5.8 3.7 7.2 5.8 1.5 1 0 0 1 1 1 0 FAM176 family Macoilin PF09726.9 ETO08254.1 - 2 6.9 17.2 2.3 6.7 17.2 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO08254.1 - 4.2 6.0 10.5 5.6 5.6 10.5 1.2 1 0 0 1 1 1 0 Presenilin MGC-24 PF05283.11 ETO08254.1 - 7.1 7.1 23.2 2.2 8.7 1.2 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin PDDEXK_6 PF04720.12 ETO08254.1 - 8.3 6.3 7.9 17 5.2 7.9 1.5 1 0 0 1 1 1 0 PDDEXK-like family of unknown function AgrB PF04647.15 ETO08256.1 - 0.82 9.0 8.1 6.2 6.1 0.2 2.3 2 0 0 2 2 2 0 Accessory gene regulator B DUF2116 PF09889.9 ETO08256.1 - 1.9 8.5 6.7 4 7.5 0.3 2.4 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DEP PF00610.21 ETO08257.1 - 1e-17 63.9 0.1 1.2e-08 34.9 0.0 2.4 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Clp_N PF02861.20 ETO08257.1 - 0.06 13.5 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Clp amino terminal domain, pathogenicity island component Rod-binding PF10135.9 ETO08257.1 - 6 7.5 8.7 1 10.0 2.7 2.9 3 0 0 3 3 3 0 Rod binding protein zf-TRAF PF02176.18 ETO08258.1 - 3.5e-06 27.6 0.8 3.5e-06 27.6 0.8 3.4 3 0 0 3 3 3 2 TRAF-type zinc finger TPR_2 PF07719.17 ETO08259.1 - 4.6e-13 48.2 7.8 0.015 15.4 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO08259.1 - 6.1e-12 44.8 8.7 0.0011 18.7 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO08259.1 - 8.2e-09 35.0 8.5 0.059 13.6 0.0 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO08259.1 - 2.9e-07 30.4 9.0 0.0031 17.8 1.2 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO08259.1 - 6.4e-06 25.8 1.6 5.2 7.3 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO08259.1 - 2.1e-05 24.1 8.2 0.099 12.3 0.3 5.0 4 1 1 5 5 5 2 TPR repeat TPR_6 PF13174.6 ETO08259.1 - 0.0002 21.8 6.0 2.9 8.7 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO08259.1 - 0.00024 21.7 0.2 2.4 9.2 0.0 3.9 3 1 2 5 5 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO08259.1 - 0.00026 21.2 9.2 0.26 11.6 0.1 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO08259.1 - 0.00095 19.3 6.0 0.75 10.1 3.8 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ETO08259.1 - 0.033 14.1 1.6 32 4.6 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat CBM_15 PF03426.14 ETO08259.1 - 0.12 11.9 0.1 0.19 11.3 0.1 1.2 1 0 0 1 1 1 0 Carbohydrate binding domain (family 15) TPR_16 PF13432.6 ETO08259.1 - 0.15 12.8 0.1 13 6.5 0.0 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat HEPN PF05168.14 ETO08259.1 - 1.6 8.9 6.5 0.13 12.4 0.6 2.2 3 1 0 3 3 3 0 HEPN domain Peptidase_S49_N PF08496.10 ETO08260.1 - 0.085 12.9 13.6 0.22 11.6 13.6 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Tti2 PF10521.9 ETO08260.1 - 2.7 7.4 8.0 5.1 6.5 8.0 1.4 1 0 0 1 1 1 0 Tti2 family AAA_11 PF13086.6 ETO08260.1 - 4.8 6.9 11.3 6.9 6.4 11.3 1.2 1 0 0 1 1 1 0 AAA domain RIC3 PF15361.6 ETO08262.1 - 0.099 13.0 2.0 0.15 12.4 2.0 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF755 PF05501.11 ETO08262.1 - 0.69 10.2 7.9 2.5 8.4 7.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF755) ERAP1_C PF11838.8 ETO08264.1 - 5.1e-16 59.1 0.6 6.1e-16 58.9 0.6 1.1 1 0 0 1 1 1 1 ERAP1-like C-terminal domain FMP23 PF17315.2 ETO08264.1 - 0.04 14.1 0.2 0.077 13.2 0.2 1.5 1 0 0 1 1 1 0 Found in mitochondrial proteome Peptidase_M1 PF01433.20 ETO08265.1 - 6.3e-22 78.2 0.1 7.2e-22 78.0 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M1 domain Serpin PF00079.20 ETO08266.1 - 1.2e-23 84.0 0.4 1.5e-23 83.7 0.4 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Peptidase_M60_C PF18630.1 ETO08266.1 - 0.02 15.0 0.1 0.067 13.3 0.1 1.9 1 0 0 1 1 1 0 Peptidase M60 C-terminal domain TetR_C_8 PF14278.6 ETO08266.1 - 0.1 12.7 0.2 0.3 11.2 0.1 1.9 1 1 1 2 2 2 0 Transcriptional regulator C-terminal region TRC8_N PF13705.6 ETO08267.1 - 0.27 10.1 6.3 0.057 12.3 1.3 1.9 2 0 0 2 2 2 0 TRC8 N-terminal domain Streptin-Immun PF11083.8 ETO08267.1 - 0.84 10.1 7.1 18 5.8 0.2 3.5 2 1 1 3 3 3 0 Lantibiotic streptin immunity protein Imm41 PF15592.6 ETO08272.1 - 0.031 14.6 2.1 0.19 12.0 0.3 2.3 2 0 0 2 2 2 0 Immunity protein 41 CCDC106 PF15794.5 ETO08273.1 - 0.23 11.2 5.7 0.31 10.7 5.7 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 TMF_DNA_bd PF12329.8 ETO08276.1 - 0.0028 17.6 16.1 0.0028 17.6 16.1 3.3 3 0 0 3 3 3 2 TATA element modulatory factor 1 DNA binding PhoU PF01895.19 ETO08276.1 - 0.065 13.7 13.3 8.6 6.9 1.4 3.6 1 1 1 2 2 2 0 PhoU domain HMMR_N PF15905.5 ETO08276.1 - 0.92 8.9 40.3 1.4 8.3 40.3 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Vac_Fusion PF02346.16 ETO08276.1 - 2.8 7.6 9.9 0.88 9.2 1.1 3.1 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Fez1 PF06818.15 ETO08276.1 - 4.3 7.7 32.4 0.44 11.0 12.0 2.3 1 1 1 2 2 2 0 Fez1 MAD PF05557.13 ETO08276.1 - 5.4 5.3 40.0 7.9 4.7 40.0 1.3 1 0 0 1 1 1 0 Mitotic checkpoint protein Glyco_hydro_47 PF01532.20 ETO08277.1 - 4.2e-28 98.5 0.0 4.4e-28 98.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ribosomal_S19e PF01090.19 ETO08278.1 - 6.5e-22 77.7 0.4 5.3e-18 65.0 0.0 2.7 3 0 0 3 3 3 2 Ribosomal protein S19e RHH_1 PF01402.21 ETO08278.1 - 0.031 14.2 0.1 0.29 11.1 0.1 2.5 2 0 0 2 2 2 0 Ribbon-helix-helix protein, copG family PH PF00169.29 ETO08280.1 - 8.2e-11 42.4 0.6 1.1e-10 42.0 0.6 1.1 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO08280.1 - 0.0046 17.4 2.2 0.0099 16.3 2.1 1.7 1 1 0 1 1 1 1 Pleckstrin homology domain Caps_synth PF05704.12 ETO08280.1 - 0.019 14.4 0.8 0.021 14.2 0.8 1.1 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein PH_15 PF17339.2 ETO08280.1 - 0.048 13.5 0.4 0.13 12.2 0.4 1.8 1 1 1 2 2 2 0 PH domain DUF3574 PF12098.8 ETO08282.1 - 0.038 13.8 0.1 1.4 8.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3574) RVT_1 PF00078.27 ETO08283.1 - 8.4e-14 51.6 0.0 1.5e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Iron_traffic PF04362.14 ETO08284.1 - 0.088 12.5 0.0 0.27 10.9 0.0 1.8 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking eIF2_C PF09173.11 ETO08284.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Initiation factor eIF2 gamma, C terminal Vut_1 PF02592.15 ETO08285.1 - 0.19 12.0 8.2 0.41 11.0 8.2 1.5 1 1 0 1 1 1 0 Putative vitamin uptake transporter PAPA-1 PF04795.12 ETO08286.1 - 0.6 10.9 25.0 1 10.2 25.0 1.5 1 1 0 1 1 1 0 PAPA-1-like conserved region Neprosin PF03080.15 ETO08288.1 - 0.039 13.3 2.5 0.062 12.6 2.5 1.3 1 0 0 1 1 1 0 Neprosin FPL PF09758.9 ETO08288.1 - 1.6 8.7 14.2 27 4.7 14.2 2.3 1 1 0 1 1 1 0 Uncharacterised conserved protein zf-RanBP PF00641.18 ETO08289.1 - 0.00015 21.0 2.6 0.00045 19.5 2.6 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Pkinase PF00069.25 ETO08290.1 - 9.6e-42 143.2 0.3 1.8e-41 142.2 0.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08290.1 - 2.9e-22 79.2 0.3 5.7e-22 78.2 0.3 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO08290.1 - 2.6e-07 30.2 1.8 2.8e-07 30.1 0.3 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO08290.1 - 0.00063 19.7 0.0 0.0028 17.6 0.0 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ETO08290.1 - 0.04 13.4 2.2 0.072 12.6 0.0 2.4 3 1 1 4 4 4 0 PhoP regulatory network protein YrbL Myc_N PF01056.18 ETO08290.1 - 0.049 13.5 6.2 0.08 12.8 6.2 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PIEZO PF15917.5 ETO08290.1 - 0.33 10.4 7.8 0.66 9.4 7.8 1.4 1 0 0 1 1 1 0 Piezo EF-hand_7 PF13499.6 ETO08291.1 - 1.9e-06 28.2 1.0 0.00017 21.9 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO08291.1 - 9.1e-05 21.7 8.1 0.2 11.3 0.3 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ETO08291.1 - 0.00065 19.4 4.5 1.2 9.3 0.1 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 ETO08291.1 - 0.0037 16.7 0.4 0.0037 16.7 0.4 3.0 3 0 0 3 3 3 1 EF hand YhdB PF14148.6 ETO08291.1 - 0.096 12.8 1.7 0.81 9.8 0.2 2.7 3 0 0 3 3 3 0 YhdB-like protein Atrophin-1 PF03154.15 ETO08292.1 - 0.00018 20.0 9.7 0.00018 20.0 9.7 1.6 2 0 0 2 2 2 1 Atrophin-1 family ERM PF00769.19 ETO08292.1 - 0.00044 20.1 15.8 0.0009 19.1 15.8 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF2956 PF11169.8 ETO08292.1 - 0.025 14.7 6.4 0.064 13.5 6.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) DUF3824 PF12868.7 ETO08292.1 - 0.05 14.3 5.6 0.18 12.4 5.7 1.9 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) DUF948 PF06103.11 ETO08292.1 - 0.13 12.5 2.3 0.21 11.9 1.4 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) BST2 PF16716.5 ETO08292.1 - 0.15 12.6 16.2 0.043 14.4 11.0 2.3 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 DUF3584 PF12128.8 ETO08292.1 - 0.28 8.7 13.8 0.4 8.1 13.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Bacillus_HBL PF05791.11 ETO08292.1 - 0.3 10.9 5.6 0.63 9.8 5.6 1.5 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) DUF1043 PF06295.12 ETO08292.1 - 0.63 10.0 15.6 0.17 11.9 10.8 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) Spc7 PF08317.11 ETO08292.1 - 0.75 8.6 15.6 1.4 7.7 15.6 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETO08292.1 - 0.81 9.7 5.1 1.5 8.8 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 ETO08292.1 - 0.92 9.0 5.1 1.6 8.2 5.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF812 PF05667.11 ETO08292.1 - 1 8.2 13.7 1.9 7.3 13.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF812) FlxA PF14282.6 ETO08292.1 - 1.2 9.1 18.3 0.42 10.6 12.8 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF4407 PF14362.6 ETO08292.1 - 2.4 7.4 9.1 4 6.7 9.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Peptidase_S49_N PF08496.10 ETO08292.1 - 2.5 8.1 7.3 6.3 6.8 7.3 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ALMT PF11744.8 ETO08292.1 - 5 5.8 7.5 8.1 5.1 7.5 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RNA_pol_3_Rpc31 PF11705.8 ETO08292.1 - 5 7.3 23.8 10 6.3 23.8 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 NuDC PF16273.5 ETO08292.1 - 5.1 7.7 21.3 5.2 7.7 19.5 1.9 1 1 1 2 2 2 0 Nuclear distribution C domain YabA PF06156.13 ETO08292.1 - 6.7 7.4 10.5 20 5.9 10.5 1.8 1 0 0 1 1 1 0 Initiation control protein YabA Synaptobrevin PF00957.21 ETO08292.1 - 8.1 6.3 8.7 6.5 6.6 5.6 2.2 2 0 0 2 2 2 0 Synaptobrevin Snf7 PF03357.21 ETO08294.1 - 4e-05 23.3 3.1 4.7e-05 23.1 3.1 1.1 1 0 0 1 1 1 1 Snf7 Ax_dynein_light PF10211.9 ETO08294.1 - 0.0014 18.6 0.6 0.0017 18.3 0.6 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain YkyA PF10368.9 ETO08294.1 - 0.014 15.1 1.7 0.017 14.8 1.7 1.1 1 0 0 1 1 1 0 Putative cell-wall binding lipoprotein PDDEXK_6 PF04720.12 ETO08294.1 - 0.018 15.0 0.0 0.021 14.8 0.0 1.0 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Prefoldin_2 PF01920.20 ETO08294.1 - 0.021 14.8 3.4 0.029 14.3 3.4 1.2 1 0 0 1 1 1 0 Prefoldin subunit MAD PF05557.13 ETO08294.1 - 0.022 13.2 0.9 0.024 13.0 0.9 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein E2F_CC-MB PF16421.5 ETO08294.1 - 0.032 14.6 0.1 0.041 14.2 0.1 1.2 1 0 0 1 1 1 0 E2F transcription factor CC-MB domain Atg14 PF10186.9 ETO08294.1 - 0.037 13.1 1.6 0.046 12.8 1.6 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Calpain_inhib PF00748.19 ETO08294.1 - 0.039 14.5 1.6 0.054 14.0 1.6 1.2 1 0 0 1 1 1 0 Calpain inhibitor Ntox28 PF15605.6 ETO08294.1 - 0.046 14.0 0.1 0.055 13.7 0.1 1.1 1 0 0 1 1 1 0 Bacterial toxin 28 Syntaxin-6_N PF09177.11 ETO08294.1 - 0.052 14.1 0.1 0.063 13.8 0.1 1.1 1 0 0 1 1 1 0 Syntaxin 6, N-terminal Prefoldin PF02996.17 ETO08294.1 - 0.055 13.4 2.4 0.071 13.0 2.4 1.2 1 0 0 1 1 1 0 Prefoldin subunit PEP-utilisers_N PF05524.13 ETO08294.1 - 0.061 13.5 0.1 0.096 12.9 0.0 1.3 2 0 0 2 2 1 0 PEP-utilising enzyme, N-terminal DivIC PF04977.15 ETO08294.1 - 0.061 13.1 2.6 0.11 12.2 2.6 1.5 1 0 0 1 1 1 0 Septum formation initiator UPF0184 PF03670.13 ETO08294.1 - 0.088 13.2 0.1 0.11 12.9 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) DUF4120 PF13496.6 ETO08294.1 - 0.11 12.9 0.4 0.19 12.1 0.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4120) Herpes_UL6 PF01763.16 ETO08294.1 - 0.19 10.2 0.8 0.23 10.0 0.8 1.0 1 0 0 1 1 1 0 Herpesvirus UL6 like TMF_DNA_bd PF12329.8 ETO08294.1 - 0.25 11.4 7.5 0.46 10.5 7.5 1.5 1 1 0 1 1 1 0 TATA element modulatory factor 1 DNA binding DUF2681 PF10883.8 ETO08294.1 - 1.7 9.1 5.5 2.6 8.5 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) YabA PF06156.13 ETO08294.1 - 6.2 7.5 7.9 5.8 7.6 1.6 2.1 1 1 1 2 2 2 0 Initiation control protein YabA Homoserine_dh PF00742.19 ETO08295.1 - 1.6e-36 125.9 0.0 3.7e-36 124.6 0.0 1.6 1 1 0 1 1 1 1 Homoserine dehydrogenase ELFV_dehydrog PF00208.21 ETO08295.1 - 2.1e-05 24.4 0.0 5.9e-05 22.9 0.0 1.7 1 1 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase NAD_binding_3 PF03447.16 ETO08295.1 - 0.0001 22.9 0.0 0.0003 21.4 0.0 1.8 1 1 0 1 1 1 1 Homoserine dehydrogenase, NAD binding domain DXP_reductoisom PF02670.16 ETO08295.1 - 0.0018 19.0 0.0 0.0053 17.5 0.0 1.8 1 1 0 1 1 1 1 1-deoxy-D-xylulose 5-phosphate reductoisomerase DUF4655 PF15548.6 ETO08295.1 - 0.063 12.2 0.0 0.094 11.7 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4655) ADK PF00406.22 ETO08296.1 - 6.4e-20 71.8 0.1 1.7e-19 70.4 0.1 1.6 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETO08296.1 - 1e-15 58.3 0.0 1.6e-15 57.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO08296.1 - 8.9e-11 42.5 0.0 1.5e-10 41.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain Rad17 PF03215.15 ETO08296.1 - 0.001 19.0 0.1 0.0017 18.3 0.1 1.4 1 1 0 1 1 1 1 Rad17 P-loop domain AAA PF00004.29 ETO08296.1 - 0.0019 18.6 0.0 0.0027 18.1 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Cytidylate_kin PF02224.18 ETO08296.1 - 0.0022 17.7 0.0 0.0056 16.4 0.0 1.5 1 1 0 1 1 1 1 Cytidylate kinase RNA_helicase PF00910.22 ETO08296.1 - 0.0028 18.0 0.0 0.0056 17.0 0.0 1.6 1 0 0 1 1 1 1 RNA helicase AAA_28 PF13521.6 ETO08296.1 - 0.0043 17.3 0.0 0.0064 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO08296.1 - 0.012 15.6 0.0 0.024 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO08296.1 - 0.017 15.5 0.0 0.024 15.0 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain Sigma54_activ_2 PF14532.6 ETO08296.1 - 0.027 14.6 0.0 0.047 13.8 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain ABC_tran PF00005.27 ETO08296.1 - 0.034 14.7 0.0 0.043 14.3 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ETO08296.1 - 0.042 14.1 0.0 0.12 12.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ETO08296.1 - 0.043 13.7 0.0 0.059 13.3 0.0 1.3 1 0 0 1 1 1 0 NTPase AAA_30 PF13604.6 ETO08296.1 - 0.053 13.2 0.0 0.066 12.9 0.0 1.1 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETO08296.1 - 0.054 13.2 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 ETO08296.1 - 0.064 12.9 0.0 0.092 12.4 0.0 1.3 1 0 0 1 1 1 0 Thymidylate kinase AAA_29 PF13555.6 ETO08296.1 - 0.068 12.9 0.1 0.15 11.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain CoaE PF01121.20 ETO08296.1 - 0.074 12.7 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Dephospho-CoA kinase TIP49 PF06068.13 ETO08296.1 - 0.078 12.2 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain NACHT PF05729.12 ETO08296.1 - 0.15 12.0 0.1 0.97 9.3 0.0 2.0 2 0 0 2 2 2 0 NACHT domain RuvB_N PF05496.12 ETO08296.1 - 0.16 11.7 0.0 0.23 11.2 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Rep_fac-A_C PF08646.10 ETO08297.1 - 4.3e-32 110.9 4.0 2.3e-31 108.5 0.1 3.3 4 0 0 4 4 4 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ETO08297.1 - 4.9e-20 71.3 0.6 4.8e-18 64.9 0.2 2.5 2 0 0 2 2 2 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ETO08297.1 - 8.2e-15 54.6 0.4 5.8e-09 35.8 0.1 3.5 4 0 0 4 4 4 2 OB-fold nucleic acid binding domain Rep-A_N PF04057.12 ETO08297.1 - 2e-13 50.2 0.9 2.1e-10 40.5 0.4 2.7 2 0 0 2 2 2 2 Replication factor-A protein 1, N-terminal domain CDC24_OB3 PF17244.2 ETO08297.1 - 0.014 15.1 0.0 0.041 13.6 0.0 1.8 2 0 0 2 2 2 0 Cell division control protein 24, OB domain 3 EF-hand_1 PF00036.32 ETO08298.1 - 3.9e-15 54.2 6.6 1.1e-06 27.7 0.6 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO08298.1 - 5.3e-15 55.6 8.2 1.9e-08 34.7 2.1 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO08298.1 - 1.2e-12 46.7 5.0 3.8e-05 23.3 0.5 4.4 3 1 1 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 ETO08298.1 - 5.1e-10 38.4 11.2 2.2e-05 23.7 0.5 4.2 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO08298.1 - 6.6e-07 29.1 7.7 0.00022 21.0 1.5 3.6 2 2 1 3 3 3 2 EF-hand domain pair Pkinase PF00069.25 ETO08298.1 - 0.0012 18.3 0.0 0.0019 17.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain SPARC_Ca_bdg PF10591.9 ETO08298.1 - 0.0012 19.1 2.4 4.7 7.6 0.1 3.3 2 2 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region YlbE PF14003.6 ETO08298.1 - 0.23 11.9 1.7 32 5.1 0.4 3.4 3 0 0 3 3 3 0 YlbE-like protein TssO PF17561.2 ETO08299.1 - 0.099 12.8 0.2 0.76 9.9 0.0 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO WD40 PF00400.32 ETO08300.1 - 3e-57 189.3 16.2 1.1e-09 38.7 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08300.1 - 1.4e-18 66.9 3.9 0.021 15.1 0.0 6.4 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08300.1 - 5.1e-15 55.6 4.1 2.6e-07 30.3 0.1 4.1 2 2 2 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO08300.1 - 1.2e-11 44.9 1.8 4.2e-06 26.8 0.3 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO08300.1 - 7e-11 41.5 6.2 0.042 12.5 0.1 4.4 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO08300.1 - 1.8e-09 37.1 0.8 0.12 11.3 0.0 5.0 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO08300.1 - 2.2e-05 23.2 0.9 0.18 10.3 0.0 3.0 1 1 1 3 3 3 2 Cytochrome D1 heme domain Gmad1 PF10647.9 ETO08300.1 - 0.0011 18.8 0.1 2.4 7.9 0.0 3.0 2 1 1 3 3 3 2 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.6 ETO08300.1 - 0.0039 16.6 1.1 3.4 6.9 0.0 3.3 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Me-amine-dh_H PF06433.11 ETO08300.1 - 0.0043 16.0 0.0 1.2 7.9 0.0 3.0 2 1 1 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) Utp8 PF10395.9 ETO08300.1 - 0.0074 14.8 2.4 0.79 8.1 0.3 2.4 1 1 1 2 2 2 2 Utp8 family Str_synth PF03088.16 ETO08300.1 - 0.0084 16.2 0.2 0.55 10.4 0.0 3.1 3 1 1 4 4 4 1 Strictosidine synthase PQQ PF01011.21 ETO08300.1 - 0.013 15.4 0.0 1.8e+02 2.3 0.0 5.3 6 0 0 6 6 6 0 PQQ enzyme repeat PD40 PF07676.12 ETO08300.1 - 0.087 12.8 0.8 20 5.3 0.1 4.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Peptidase_C10 PF01640.17 ETO08301.1 - 0.077 13.3 0.7 0.11 12.8 0.7 1.4 1 1 0 1 1 1 0 Peptidase C10 family F_actin_cap_B PF01115.17 ETO08302.1 - 4e-56 190.3 0.1 5.9e-56 189.8 0.1 1.2 1 1 0 1 1 1 1 F-actin capping protein, beta subunit DUF3644 PF12358.8 ETO08302.1 - 0.11 13.0 0.4 0.28 11.7 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3644) DUSP PF06337.12 ETO08303.1 - 6.6e-12 45.9 0.1 1.2e-11 45.0 0.1 1.5 1 0 0 1 1 1 1 DUSP domain DUF3807 PF12720.7 ETO08304.1 - 0.37 11.0 18.7 0.43 10.8 18.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CDC45 PF02724.14 ETO08304.1 - 0.47 8.7 17.8 0.55 8.5 17.8 1.0 1 0 0 1 1 1 0 CDC45-like protein NST1 PF13945.6 ETO08304.1 - 1.9 8.6 25.5 2.8 8.0 25.5 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Neur_chan_memb PF02932.16 ETO08304.1 - 2.1 8.4 11.9 2.5 8.1 11.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_M36 PF02128.15 ETO08304.1 - 2.4 7.2 13.9 2.9 7.0 13.9 1.2 1 0 0 1 1 1 0 Fungalysin metallopeptidase (M36) RR_TM4-6 PF06459.12 ETO08304.1 - 2.6 7.8 19.3 3.3 7.5 19.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TP53IP5 PF15331.6 ETO08304.1 - 5.6 7.0 16.9 6.9 6.8 16.9 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Menin PF05053.13 ETO08304.1 - 6.7 4.9 20.0 7.1 4.9 20.0 1.1 1 0 0 1 1 1 0 Menin Lin-8 PF03353.15 ETO08304.1 - 6.8 6.2 19.0 8.3 5.9 19.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Membralin PF09746.9 ETO08304.1 - 7.3 5.5 12.9 8.6 5.3 12.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein Zip PF02535.22 ETO08305.1 - 2.4 7.3 5.4 2.4 7.3 5.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO08305.1 - 6.4 5.4 14.8 7.9 5.1 14.8 1.2 1 0 0 1 1 1 0 Presenilin Inhibitor_I71 PF12628.7 ETO08305.1 - 7.4 6.4 18.3 11 5.8 17.3 1.7 1 1 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Paramyxo_ncap PF00973.19 ETO08305.1 - 7.7 5.3 10.6 8.7 5.1 10.6 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Laminin_G_3 PF13385.6 ETO08306.1 - 9.4e-06 25.9 1.2 1.2e-05 25.5 1.2 1.2 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF2929 PF11151.8 ETO08306.1 - 0.35 11.2 3.0 12 6.3 1.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2929) Vps36-NZF-N PF16988.5 ETO08308.1 - 0.0026 17.1 0.0 0.008 15.6 0.0 1.9 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-C2H2_2 PF12756.7 ETO08308.1 - 0.031 14.6 1.1 0.031 14.6 1.1 2.4 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF3977 PF13122.6 ETO08308.1 - 0.033 14.4 0.0 0.091 13.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3977) TLD PF07534.16 ETO08309.1 - 1.3e-26 93.4 0.7 3.1e-26 92.3 0.3 1.9 2 0 0 2 2 2 1 TLD KxDL PF10241.9 ETO08309.1 - 0.016 15.5 4.3 0.016 15.5 4.3 4.0 2 1 1 4 4 4 0 Uncharacterized conserved protein DUF1664 PF07889.12 ETO08309.1 - 0.35 10.9 16.8 0.13 12.3 1.2 3.7 2 2 1 3 3 3 0 Protein of unknown function (DUF1664) EphA2_TM PF14575.6 ETO08310.1 - 0.0003 21.6 1.5 0.0056 17.5 0.2 2.9 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 ETO08310.1 - 0.00096 20.1 0.7 0.00096 20.1 0.7 3.7 4 0 0 4 4 4 1 Domain of unknown function (DUF4834) DUF2207 PF09972.9 ETO08310.1 - 0.0021 16.9 0.3 0.73 8.5 0.0 2.3 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) Shisa PF13908.6 ETO08310.1 - 0.0069 16.6 1.3 0.0069 16.6 1.3 2.4 3 0 0 3 3 3 1 Wnt and FGF inhibitory regulator Orf78 PF06024.12 ETO08310.1 - 0.012 15.9 1.0 0.012 15.9 1.0 4.5 4 0 0 4 4 4 0 Orf78 (ac78) CitMHS PF03600.16 ETO08310.1 - 0.12 11.5 0.2 3.4 6.8 0.0 2.1 2 0 0 2 2 2 0 Citrate transporter Tmemb_9 PF05434.11 ETO08310.1 - 1.3 8.9 7.7 2 8.3 1.4 2.8 2 0 0 2 2 2 0 TMEM9 Sigma_reg_N PF13800.6 ETO08310.1 - 2.3 8.6 17.4 0.27 11.5 7.9 2.6 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Coprogen_oxidas PF01218.18 ETO08311.1 - 2.8e-85 285.6 0.0 4.4e-85 285.0 0.0 1.3 1 1 0 1 1 1 1 Coproporphyrinogen III oxidase NKAIN PF05640.14 ETO08312.1 - 0.92 8.7 10.1 1.4 8.1 10.1 1.3 1 0 0 1 1 1 0 Na,K-Atpase Interacting protein Pkinase PF00069.25 ETO08314.1 - 1.8e-08 34.1 0.9 2.1e-08 33.8 0.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08314.1 - 1.1e-05 24.8 0.1 1.2e-05 24.8 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Lysozyme_like PF13702.6 ETO08315.1 - 0.057 13.1 0.1 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 Lysozyme-like Phage_ABA_S PF18066.1 ETO08315.1 - 0.18 12.5 0.4 0.54 11.0 0.4 1.8 1 0 0 1 1 1 0 Phage ABA sandwich domain WD40 PF00400.32 ETO08316.1 - 1.9e-37 126.6 21.5 1e-06 29.4 0.3 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO08316.1 - 3e-13 49.3 6.1 0.036 12.7 0.0 5.9 2 2 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08316.1 - 7.6e-12 45.4 0.6 0.0065 16.8 0.0 5.4 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08316.1 - 1.4e-05 24.6 7.2 0.022 14.1 1.2 4.4 1 1 2 4 4 4 3 WD40-like domain WD40 PF00400.32 ETO08317.1 - 6.5e-25 86.9 10.1 1.2e-05 26.0 0.0 5.8 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08317.1 - 2.5e-06 27.7 0.6 0.095 13.0 0.0 4.0 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08317.1 - 8.1e-05 21.5 2.9 2.7 6.5 0.0 4.6 1 1 2 5 5 5 3 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO08317.1 - 3 7.8 0.0 3 7.8 0.0 4.1 5 1 0 5 5 5 0 ATP-dependent RecD-like DNA helicase SH3 domain ERAP1_C PF11838.8 ETO08319.1 - 0.018 14.6 0.1 0.027 14.0 0.1 1.3 1 0 0 1 1 1 0 ERAP1-like C-terminal domain Pox_E10 PF04805.12 ETO08319.1 - 0.018 14.9 0.4 0.018 14.9 0.4 2.1 1 1 1 2 2 2 0 E10-like protein conserved region SLIDE PF09111.10 ETO08320.1 - 0.073 13.1 0.4 0.16 12.0 0.4 1.5 1 0 0 1 1 1 0 SLIDE HSP70 PF00012.20 ETO08321.1 - 4.5e-116 388.4 4.4 6e-94 315.3 1.7 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO08321.1 - 4.3e-10 38.9 0.0 7.4e-10 38.1 0.0 1.3 1 0 0 1 1 1 1 MreB/Mbl protein Hydantoinase_A PF01968.18 ETO08321.1 - 0.099 11.9 0.0 0.15 11.3 0.0 1.3 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase PA28_alpha PF02251.18 ETO08321.1 - 0.1 12.6 1.8 0.12 12.4 0.2 1.9 2 0 0 2 2 2 0 Proteasome activator pa28 alpha subunit DUF5635 PF18685.1 ETO08321.1 - 0.17 11.8 0.1 18 5.4 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5635) ABC_membrane_3 PF13748.6 ETO08322.1 - 0.058 12.6 0.0 0.068 12.4 0.0 1.1 1 0 0 1 1 1 0 ABC transporter transmembrane region PPR_2 PF13041.6 ETO08324.1 - 1.4e-11 44.4 6.6 0.047 13.9 0.1 5.1 3 1 1 4 4 4 4 PPR repeat family PPR PF01535.20 ETO08324.1 - 1.6e-10 40.5 8.1 0.11 12.8 0.2 5.1 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 ETO08324.1 - 1.1e-06 28.6 6.7 0.44 10.7 0.0 4.9 3 2 1 4 4 4 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO08324.1 - 0.0046 16.6 3.7 0.97 9.2 0.0 4.1 4 0 0 4 4 4 1 PPR repeat RL PF17797.1 ETO08324.1 - 0.08 12.9 0.1 0.4 10.7 0.1 2.2 1 0 0 1 1 1 0 RL domain SAND PF01342.21 ETO08324.1 - 0.085 12.6 0.3 0.4 10.4 0.3 2.2 1 0 0 1 1 1 0 SAND domain ChaC PF04752.12 ETO08325.1 - 7.3e-48 163.0 0.0 8.6e-48 162.7 0.0 1.0 1 0 0 1 1 1 1 ChaC-like protein GGACT PF06094.12 ETO08325.1 - 3.3e-05 24.5 0.0 5e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like DUF1129 PF06570.11 ETO08325.1 - 0.0044 16.5 0.6 0.0078 15.7 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) AIG2_2 PF13772.6 ETO08325.1 - 0.014 15.8 0.0 0.024 15.0 0.0 1.4 1 0 0 1 1 1 0 AIG2-like family 7TM_GPCR_Srb PF02175.16 ETO08326.1 - 0.024 14.4 10.2 0.68 9.7 2.1 2.8 2 1 1 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srb DUF1929 PF09118.11 ETO08327.1 - 0.19 12.0 0.0 0.33 11.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1929) Amidinotransf PF02274.17 ETO08329.1 - 0.0024 17.0 2.0 0.0037 16.4 1.3 1.6 1 1 0 1 1 1 1 Amidinotransferase Fib_alpha PF08702.10 ETO08329.1 - 0.019 15.2 6.2 0.019 15.2 6.2 3.0 3 1 1 4 4 4 0 Fibrinogen alpha/beta chain family V-SNARE PF05008.15 ETO08329.1 - 0.56 10.6 0.0 0.56 10.6 0.0 3.9 5 1 0 5 5 5 0 Vesicle transport v-SNARE protein N-terminus DUF641 PF04859.12 ETO08329.1 - 0.61 10.4 10.6 3.4 8.0 2.4 3.1 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) ARA70 PF12489.8 ETO08329.1 - 0.76 10.0 10.0 0.069 13.3 2.8 2.4 1 1 0 2 2 2 0 Nuclear coactivator SlyX PF04102.12 ETO08329.1 - 2.5 8.8 18.4 0.097 13.3 2.5 4.0 3 1 2 5 5 5 0 SlyX Transcrip_act PF04949.13 ETO08329.1 - 3.8 7.4 10.7 1.3 8.9 4.9 2.9 2 1 1 3 3 3 0 Transcriptional activator IMPDH PF00478.25 ETO08330.1 - 2.9e-29 102.2 0.3 3.3e-29 102.0 0.3 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain IMPDH PF00478.25 ETO08331.1 - 7e-62 209.4 2.2 8.6e-62 209.1 2.2 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ETO08331.1 - 1.5e-14 54.2 0.0 2.7e-07 30.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 ETO08331.1 - 8.7e-05 21.7 0.3 0.00014 21.0 0.3 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase PK PF00224.21 ETO08331.1 - 0.003 16.5 0.0 0.0044 16.0 0.0 1.3 1 0 0 1 1 1 1 Pyruvate kinase, barrel domain YpsA PF06908.11 ETO08331.1 - 0.0033 17.4 0.0 0.007 16.4 0.0 1.5 1 0 0 1 1 1 1 YspA SLOG family His_biosynth PF00977.21 ETO08331.1 - 0.012 15.1 0.6 1.2 8.5 0.0 2.6 1 1 0 1 1 1 0 Histidine biosynthesis protein B12-binding PF02310.19 ETO08331.1 - 0.016 15.3 0.1 0.025 14.6 0.1 1.3 1 0 0 1 1 1 0 B12 binding domain Cation_ATPase_C PF00689.21 ETO08333.1 - 1.1e-17 64.3 5.6 1.1e-17 64.3 5.6 2.6 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus DUF2367 PF10164.9 ETO08333.1 - 6.7 7.3 7.8 15 6.1 7.8 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2367) GNT-I PF03071.15 ETO08334.1 - 0.15 10.8 0.6 0.2 10.4 0.6 1.1 1 0 0 1 1 1 0 GNT-I family SPP PF06550.11 ETO08335.1 - 0.013 15.0 0.5 0.014 14.9 0.5 1.1 1 0 0 1 1 1 0 Signal-peptide peptidase, presenilin aspartyl protease FUSC_2 PF13515.6 ETO08335.1 - 0.08 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein-like BUD22 PF09073.10 ETO08337.1 - 0.017 14.5 40.8 0.016 14.6 14.7 2.3 2 0 0 2 2 2 0 BUD22 Utp14 PF04615.13 ETO08337.1 - 0.34 9.4 51.8 0.042 12.5 21.1 2.2 2 0 0 2 2 2 0 Utp14 protein CAP_GLY PF01302.25 ETO08339.1 - 8.8e-33 112.1 2.7 1.3e-17 63.5 0.1 2.4 2 0 0 2 2 2 2 CAP-Gly domain BACK PF07707.15 ETO08339.1 - 5.3e-07 29.7 0.1 0.00023 21.2 0.1 2.7 2 0 0 2 2 2 2 BTB And C-terminal Kelch RNR_N PF08343.10 ETO08341.1 - 0.011 15.8 2.1 0.026 14.5 2.1 1.7 1 0 0 1 1 1 0 Ribonucleotide reductase N-terminal GNAT_acetyltran PF12746.7 ETO08341.1 - 0.052 13.1 0.2 0.061 12.9 0.2 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase DUF1090 PF06476.12 ETO08341.1 - 0.11 12.7 0.2 0.16 12.1 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) CREPT PF16566.5 ETO08341.1 - 0.34 11.1 3.5 0.74 10.0 3.5 1.6 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Kelch_2 PF07646.15 ETO08344.1 - 2e-07 30.7 1.7 0.0041 17.0 0.3 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO08344.1 - 4.4e-07 29.4 0.0 0.00024 20.6 0.2 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO08344.1 - 3.7e-06 27.0 1.8 1.2 9.5 0.2 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO08344.1 - 1.5e-05 24.9 0.1 0.0087 16.0 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08344.1 - 0.12 12.3 0.9 1 9.4 0.2 3.0 4 0 0 4 4 4 0 Kelch motif CTP_transf_1 PF01148.20 ETO08344.1 - 0.14 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Cytidylyltransferase family Serpin PF00079.20 ETO08345.1 - 2.9e-13 49.9 1.1 3.2e-13 49.7 1.1 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 ETO08346.1 - 3.4e-23 82.5 0.0 3.6e-23 82.5 0.0 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) MIF4G PF02854.19 ETO08347.1 - 3.4e-08 33.4 4.7 3.9e-07 29.9 1.5 3.0 3 0 0 3 3 3 1 MIF4G domain MukF_M PF17192.4 ETO08347.1 - 0.057 13.2 1.5 0.15 11.7 0.1 2.1 2 0 0 2 2 2 0 MukF middle domain CNOT1_CAF1_bind PF16415.5 ETO08347.1 - 0.17 11.3 3.7 2.1 7.7 0.3 2.3 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain FlaG PF03646.15 ETO08347.1 - 0.27 11.4 0.1 0.27 11.4 0.1 2.8 3 0 0 3 3 3 0 FlaG protein CREPT PF16566.5 ETO08347.1 - 1.2 9.3 4.7 1.2 9.4 1.3 2.4 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Glyco_transf_92 PF01697.27 ETO08348.1 - 3.6e-08 33.4 5.5 6.4e-08 32.6 5.5 1.5 1 1 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO08348.1 - 2.8e-05 24.5 1.4 7.4e-05 23.2 1.4 1.8 1 1 0 1 1 1 1 Glycosyl transferase family 2 GST_N PF02798.20 ETO08350.1 - 3.5e-13 49.7 0.0 6.3e-13 48.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ETO08350.1 - 1.1e-10 41.7 0.0 2.8e-10 40.4 0.0 1.7 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETO08350.1 - 1.2e-10 41.6 0.1 1.9e-10 40.9 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETO08350.1 - 9.3e-08 32.2 0.0 1.7e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETO08350.1 - 9.7e-06 25.5 0.0 1.5e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO08350.1 - 2.9e-05 24.2 0.0 5.5e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 ETO08350.1 - 0.05 14.4 0.1 3.4 8.5 0.1 2.5 1 1 0 1 1 1 0 Glutathione S-transferase N-terminal domain SET PF00856.28 ETO08351.1 - 2.5e-11 44.3 0.0 2.5e-11 44.3 0.0 2.1 2 1 0 2 2 2 1 SET domain DUF4094 PF13334.6 ETO08351.1 - 0.031 14.7 6.5 0.73 10.3 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) Secretin_N_2 PF07655.13 ETO08351.1 - 0.19 12.3 9.3 0.42 11.2 5.8 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF272 PF03312.15 ETO08351.1 - 1.9 8.8 9.0 2.2 8.5 1.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF272) GRP PF07172.11 ETO08353.1 - 0.1 13.3 11.7 0.18 12.5 11.7 1.5 1 0 0 1 1 1 0 Glycine rich protein family PIEZO PF15917.5 ETO08353.1 - 1.3 8.4 8.0 1.9 7.9 8.0 1.2 1 0 0 1 1 1 0 Piezo Kelch_1 PF01344.25 ETO08354.1 - 4.8e-05 22.8 0.2 0.0026 17.3 0.1 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO08354.1 - 0.019 14.9 1.1 0.36 10.9 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO08354.1 - 0.032 14.2 1.0 0.51 10.4 0.1 2.6 2 1 0 2 2 2 0 Kelch motif DUF5520 PF17658.1 ETO08354.1 - 0.038 13.1 0.2 0.047 12.8 0.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5520) WD40 PF00400.32 ETO08355.1 - 2.6e-14 53.4 13.0 1.3e-07 32.2 0.3 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO08355.1 - 0.00015 20.5 2.2 0.37 9.4 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08355.1 - 0.0042 17.4 0.7 27 5.1 0.1 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO08355.1 - 0.018 13.8 1.8 0.28 9.9 0.9 2.5 1 1 0 1 1 1 0 Nup133 N terminal like WD40 PF00400.32 ETO08356.1 - 1e-06 29.3 0.9 0.0089 16.9 0.3 2.4 2 1 0 2 2 2 2 WD domain, G-beta repeat PT PF04886.12 ETO08359.1 - 0.00022 20.7 45.4 0.00083 18.8 4.0 4.8 2 1 0 2 2 2 1 PT repeat DUF5595 PF18077.1 ETO08360.1 - 0.13 12.4 0.1 0.13 12.4 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5595) Clp1 PF06807.14 ETO08360.1 - 6 7.3 8.1 30 5.1 0.3 3.7 2 2 1 3 3 3 0 Pre-mRNA cleavage complex II protein Clp1 Rit1_C PF17184.4 ETO08361.1 - 0.0016 18.0 3.4 0.0019 17.7 3.4 1.1 1 0 0 1 1 1 1 Rit1 N-terminal domain Prp18 PF02840.15 ETO08361.1 - 0.074 13.1 5.1 0.11 12.5 5.1 1.4 1 0 0 1 1 1 0 Prp18 domain LEF-9 PF05094.12 ETO08361.1 - 0.075 11.5 10.0 0.051 12.1 8.1 1.5 1 1 1 2 2 2 0 Late expression factor 9 (LEF-9) ABC2_membrane_3 PF12698.7 ETO08361.1 - 0.2 10.7 3.5 0.29 10.2 3.5 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein YpjP PF14005.6 ETO08361.1 - 0.26 11.3 5.2 0.36 10.9 5.2 1.3 1 0 0 1 1 1 0 YpjP-like protein DUF349 PF03993.12 ETO08361.1 - 0.56 10.5 4.7 1.8 8.9 4.7 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) RNase_J_C PF17770.1 ETO08361.1 - 0.7 11.0 10.1 3.7 8.7 1.9 2.3 1 1 1 2 2 2 0 Ribonuclease J C-terminal domain DUF2877 PF11392.8 ETO08361.1 - 0.81 10.4 3.6 0.61 10.8 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2877) P16-Arc PF04699.14 ETO08361.1 - 1.2 9.6 6.5 0.35 11.4 2.8 1.7 1 1 1 2 2 2 0 ARP2/3 complex 16 kDa subunit (p16-Arc) LPP20 PF02169.16 ETO08361.1 - 7.3 7.0 11.7 1.2 9.5 6.7 1.9 1 1 1 2 2 2 0 LPP20 lipoprotein Occludin_ELL PF07303.13 ETO08361.1 - 7.4 7.4 10.7 31 5.4 9.4 2.1 1 1 1 2 2 2 0 Occludin homology domain FtsA PF14450.6 ETO08362.1 - 0.056 13.9 0.0 0.5 10.8 0.0 2.4 2 1 0 2 2 2 0 Cell division protein FtsA BTG PF07742.12 ETO08362.1 - 0.066 13.1 0.2 0.2 11.5 0.1 1.8 2 0 0 2 2 2 0 BTG family Peptidase_M22 PF00814.25 ETO08362.1 - 0.13 12.0 0.1 0.28 10.8 0.0 1.5 2 0 0 2 2 2 0 Glycoprotease family HSP70 PF00012.20 ETO08362.1 - 0.7 8.0 7.7 7.9 4.5 0.0 3.0 3 0 0 3 3 3 0 Hsp70 protein Gemini_AL1_M PF08283.11 ETO08362.1 - 1 9.5 6.1 0.22 11.6 0.3 2.6 2 0 0 2 2 2 0 Geminivirus rep protein central domain Band_3_cyto PF07565.13 ETO08362.1 - 1.2 8.9 3.8 2.1 8.1 3.8 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain KxDL PF10241.9 ETO08363.1 - 0.0011 19.2 9.0 0.016 15.4 3.1 2.8 3 0 0 3 3 3 2 Uncharacterized conserved protein Serine_rich PF08824.10 ETO08363.1 - 0.0012 18.9 3.7 0.0022 18.0 3.7 1.4 1 0 0 1 1 1 1 Serine rich protein interaction domain EspB PF05802.11 ETO08363.1 - 0.0019 18.2 0.1 0.0036 17.3 0.1 1.4 1 0 0 1 1 1 1 Enterobacterial EspB protein Nup54_C PF18437.1 ETO08363.1 - 0.027 14.4 0.8 0.027 14.4 0.8 2.5 3 0 0 3 3 3 0 Nup54 C-terminal interacting domain Apolipoprotein PF01442.18 ETO08363.1 - 0.027 14.3 10.0 0.053 13.4 10.0 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain SAM_2 PF07647.17 ETO08363.1 - 0.067 13.3 1.8 1.1 9.4 0.0 3.2 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) kleA_kleC PF17383.2 ETO08363.1 - 0.41 11.0 1.9 1.1 9.6 1.5 1.9 1 1 1 2 2 2 0 Uncharacterized KorC regulated protein A YtxH PF12732.7 ETO08363.1 - 0.47 11.0 6.4 8.4 7.0 1.2 3.2 3 0 0 3 3 3 0 YtxH-like protein CENP-F_leu_zip PF10473.9 ETO08363.1 - 0.47 10.5 13.0 1 9.4 12.6 1.7 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GvpL_GvpF PF06386.11 ETO08363.1 - 0.59 10.0 3.9 1 9.2 3.9 1.3 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF DUF3323 PF11796.8 ETO08363.1 - 0.7 9.7 4.1 1.2 9.0 4.1 1.3 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) CENP-H PF05837.12 ETO08363.1 - 1.8 9.0 9.1 4.3 7.8 9.1 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Sec34 PF04136.15 ETO08363.1 - 2.7 7.9 8.5 5.3 6.9 6.6 2.1 1 1 1 2 2 2 0 Sec34-like family DUF2408 PF10303.9 ETO08363.1 - 5.4 7.6 9.9 4.5 7.9 3.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Vasohibin PF14822.6 ETO08364.1 - 0.029 13.6 0.4 0.071 12.3 0.1 1.7 2 0 0 2 2 2 0 Vasohibin Hormone_6 PF00236.18 ETO08364.1 - 0.043 13.8 3.4 0.051 13.6 1.3 2.1 2 1 1 3 3 3 0 Glycoprotein hormone WD40 PF00400.32 ETO08366.1 - 1.1e-37 127.4 29.1 1.7e-05 25.5 0.5 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08366.1 - 3.8e-15 55.9 1.0 0.0067 16.7 0.0 5.7 5 1 0 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08366.1 - 6.8e-11 41.5 6.8 0.071 11.8 0.0 5.6 2 2 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08366.1 - 2.7e-06 26.9 6.4 0.2 10.9 0.3 4.7 1 1 1 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO08367.1 - 0.00017 22.3 1.3 0.00096 19.9 0.3 2.6 2 2 0 2 2 2 1 WD domain, G-beta repeat DUF2651 PF10852.8 ETO08367.1 - 0.01 16.5 6.4 0.017 15.7 6.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2651) WD40 PF00400.32 ETO08368.1 - 1.8e-50 167.8 11.2 8.9e-10 39.0 0.2 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO08368.1 - 3.6e-16 59.0 0.4 0.0042 16.1 0.0 5.1 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO08368.1 - 3.6e-14 52.8 0.9 0.015 15.6 0.0 5.9 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO08368.1 - 1.1e-09 38.5 0.3 9.2e-06 25.7 0.0 3.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO08368.1 - 1.3e-07 31.3 6.3 0.028 13.8 0.1 3.1 2 1 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO08368.1 - 5.7e-06 25.1 1.0 0.032 12.8 0.0 3.3 1 1 3 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO08368.1 - 9.9e-06 25.4 1.2 4.5 7.3 0.1 4.4 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO08368.1 - 1.1e-05 24.3 2.9 0.33 9.6 0.0 3.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO08368.1 - 0.0071 16.4 0.1 0.17 12.0 0.0 2.7 3 0 0 3 3 2 1 Strictosidine synthase Proteasome_A_N PF10584.9 ETO08368.1 - 0.0079 15.9 1.3 11 5.8 0.0 4.2 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO08368.1 - 0.0081 16.0 0.1 18 5.5 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat SGL PF08450.12 ETO08368.1 - 0.01 15.4 0.1 0.71 9.4 0.0 2.4 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Nucleoporin_N PF08801.11 ETO08368.1 - 0.27 9.9 3.1 2.7 6.7 0.0 3.1 2 1 1 4 4 4 0 Nup133 N terminal like EF-hand_6 PF13405.6 ETO08369.1 - 0.013 15.4 0.1 0.031 14.2 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain Aminotran_1_2 PF00155.21 ETO08371.1 - 1.4e-55 189.0 0.0 1.8e-55 188.6 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II MerR_1 PF13411.6 ETO08371.1 - 0.092 12.9 0.0 0.29 11.3 0.0 1.8 1 0 0 1 1 1 0 MerR HTH family regulatory protein Actin PF00022.19 ETO08373.1 - 1.5e-50 172.1 0.0 1.8e-50 171.8 0.0 1.1 1 0 0 1 1 1 1 Actin PCuAC PF04314.13 ETO08374.1 - 1.7 8.5 4.7 3.7 7.4 0.3 2.6 2 1 0 2 2 2 0 Copper chaperone PCu(A)C Phage_GP20 PF06810.11 ETO08374.1 - 2.8 7.7 39.6 3.1 7.6 13.3 3.3 2 1 1 3 3 3 0 Phage minor structural protein GP20 Spc7 PF08317.11 ETO08374.1 - 9 5.1 45.4 0.29 10.0 10.6 2.9 1 1 1 2 2 2 0 Spc7 kinetochore protein NPR3 PF03666.13 ETO08376.1 - 0.027 13.3 18.3 0.029 13.2 18.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Raftlin PF15250.6 ETO08376.1 - 0.11 11.2 13.0 0.12 11.1 13.0 1.0 1 0 0 1 1 1 0 Raftlin Vfa1 PF08432.10 ETO08376.1 - 0.12 12.7 20.4 0.15 12.4 20.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 ETO08376.1 - 0.27 10.0 17.5 0.26 10.0 17.5 1.0 1 0 0 1 1 1 0 Presenilin AAR2 PF05282.11 ETO08376.1 - 0.27 10.6 9.3 0.33 10.3 9.3 1.1 1 0 0 1 1 1 0 AAR2 protein CSRNP_N PF16019.5 ETO08376.1 - 0.39 10.6 11.7 0.51 10.2 11.7 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus RR_TM4-6 PF06459.12 ETO08376.1 - 0.64 9.8 15.2 0.76 9.6 15.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF936 PF06075.12 ETO08376.1 - 0.64 8.9 12.7 0.65 8.9 12.7 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) SLC12 PF03522.15 ETO08376.1 - 1 8.3 20.7 1.1 8.2 20.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Rtf2 PF04641.12 ETO08376.1 - 1.2 8.5 18.1 1.5 8.1 18.1 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger Sec62 PF03839.16 ETO08376.1 - 1.2 8.6 15.4 1.5 8.2 15.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 ETO08376.1 - 1.3 8.1 11.3 1.5 7.9 11.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Gti1_Pac2 PF09729.9 ETO08376.1 - 1.4 9.0 16.7 1.8 8.7 16.7 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family FAM60A PF15396.6 ETO08376.1 - 1.5 8.7 15.8 1.8 8.6 15.8 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 ETO08376.1 - 1.7 6.9 18.2 1.7 6.9 18.2 1.0 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 ETO08376.1 - 1.8 8.8 14.4 2.4 8.4 14.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated MMU163 PF17119.5 ETO08376.1 - 2.1 7.5 10.8 2.3 7.3 10.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis PPL5 PF18168.1 ETO08376.1 - 2.2 7.5 13.3 3 7.1 13.3 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DDHD PF02862.17 ETO08376.1 - 2.6 8.2 11.4 3.3 7.8 11.4 1.2 1 0 0 1 1 1 0 DDHD domain NARP1 PF12569.8 ETO08376.1 - 2.7 6.8 18.0 3.3 6.5 18.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Paramyxo_ncap PF00973.19 ETO08376.1 - 3.1 6.6 13.6 3.5 6.4 13.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Hamartin PF04388.12 ETO08376.1 - 3.7 6.1 12.5 4 6.0 12.5 1.0 1 0 0 1 1 1 0 Hamartin protein CLN3 PF02487.17 ETO08376.1 - 4.6 6.2 7.6 4.9 6.1 7.6 1.2 1 0 0 1 1 1 0 CLN3 protein Dapper PF15268.6 ETO08376.1 - 5.7 5.7 15.7 6.3 5.5 15.7 1.0 1 0 0 1 1 1 0 Dapper HCO3_cotransp PF00955.21 ETO08376.1 - 6.6 5.4 7.7 6.9 5.4 7.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF3535 PF12054.8 ETO08376.1 - 6.7 5.8 11.5 8.7 5.5 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) Macoilin PF09726.9 ETO08376.1 - 7.2 5.0 17.7 8.2 4.8 17.7 1.1 1 0 0 1 1 1 0 Macoilin family XRN_M PF17846.1 ETO08376.1 - 8.8 5.2 17.0 9.2 5.1 17.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Pox_Ag35 PF03286.14 ETO08376.1 - 9.4 6.0 22.1 15 5.3 22.1 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Pkinase PF00069.25 ETO08379.1 - 0.036 13.4 0.0 0.056 12.8 0.0 1.3 1 1 0 1 1 1 0 Protein kinase domain FIN1 PF17300.2 ETO08380.1 - 0.0077 15.8 3.0 0.0077 15.8 3.0 1.5 2 0 0 2 2 2 1 Filaments in between nuclei protein-1 DUF2379 PF09543.10 ETO08380.1 - 0.045 13.9 0.1 0.078 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2379) HSBP1 PF06825.12 ETO08380.1 - 0.063 13.1 1.5 0.17 11.8 1.5 1.7 1 0 0 1 1 1 0 Heat shock factor binding protein 1 ABC_tran_CTD PF16326.5 ETO08380.1 - 0.1 12.8 1.8 1.2 9.5 0.5 2.8 3 0 0 3 3 3 0 ABC transporter C-terminal domain XhlA PF10779.9 ETO08380.1 - 10 6.4 9.2 1 9.6 3.4 2.5 2 0 0 2 2 2 0 Haemolysin XhlA zf-RING_2 PF13639.6 ETO08384.1 - 7.9e-09 35.7 10.0 7.9e-09 35.7 10.0 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO08384.1 - 1.3e-06 28.1 5.1 1.3e-06 28.1 5.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO08384.1 - 4.9e-06 26.3 7.0 4.9e-06 26.3 7.0 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO08384.1 - 6.5e-06 25.8 7.4 6.5e-06 25.8 7.4 2.5 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO08384.1 - 4.7e-05 23.3 5.0 4.7e-05 23.3 5.0 2.9 3 0 0 3 3 3 1 RING-type zinc-finger PHD PF00628.29 ETO08384.1 - 9.4e-05 22.2 5.9 9.4e-05 22.2 5.9 2.4 2 0 0 2 2 2 1 PHD-finger zf-rbx1 PF12678.7 ETO08384.1 - 0.0012 19.1 10.1 0.0012 19.1 10.1 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETO08384.1 - 0.0053 16.7 8.9 0.013 15.4 7.5 2.3 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETO08384.1 - 0.012 15.8 5.7 0.012 15.8 5.7 2.4 1 1 1 2 2 1 0 zinc finger of C3HC4-type, RING Zn-ribbon_8 PF09723.10 ETO08384.1 - 0.047 13.8 0.7 0.047 13.8 0.7 2.4 3 0 0 3 3 2 0 Zinc ribbon domain zf-ANAPC11 PF12861.7 ETO08384.1 - 0.096 12.8 10.1 0.047 13.8 6.9 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD_4 PF16866.5 ETO08384.1 - 0.56 10.3 11.3 2.3 8.4 8.3 3.1 2 1 0 2 2 2 0 PHD-finger zf-MIZ PF02891.20 ETO08384.1 - 0.61 9.9 7.6 2.4 8.0 7.6 2.0 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-Di19 PF05605.12 ETO08384.1 - 3.4 8.1 9.9 0.57 10.5 3.0 2.8 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Zn_ribbon_17 PF17120.5 ETO08384.1 - 3.5 7.3 14.5 9.2 6.0 14.5 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-HC5HC2H PF13771.6 ETO08384.1 - 6 7.2 14.3 0.43 10.9 6.1 2.6 2 1 1 3 3 3 0 PHD-like zinc-binding domain EF-hand_7 PF13499.6 ETO08385.1 - 1.5e-13 51.0 5.9 4.5e-09 36.6 2.9 3.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO08385.1 - 5.3e-13 47.8 3.7 0.00024 20.8 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 ETO08385.1 - 7.3e-13 47.1 5.8 1e-05 24.7 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO08385.1 - 2.7e-05 23.9 4.8 0.0017 18.1 0.3 3.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO08385.1 - 3.5e-05 23.1 1.3 0.0084 15.6 0.0 3.7 4 0 0 4 4 4 1 EF hand EF-hand_4 PF12763.7 ETO08385.1 - 0.0017 18.3 1.5 0.37 10.8 0.2 2.3 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ETO08385.1 - 0.019 15.3 0.1 0.12 12.7 0.1 2.2 1 1 1 2 2 2 0 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO08385.1 - 0.036 14.4 0.8 0.99 9.7 0.1 2.3 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ETO08385.1 - 0.067 13.4 1.0 0.67 10.2 0.8 2.4 1 1 2 3 3 3 0 Dockerin type I domain E2F_TDP PF02319.20 ETO08385.1 - 0.073 13.1 0.1 0.36 10.9 0.0 2.1 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain AdoHcyase_NAD PF00670.21 ETO08386.1 - 2e-83 278.3 4.6 2.6e-83 278.0 4.6 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 ETO08386.1 - 1.2e-48 165.8 0.0 1.4e-48 165.6 0.0 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase 2-Hacid_dh_C PF02826.19 ETO08386.1 - 2.4e-08 33.6 0.2 3.7e-08 32.9 0.2 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IlvN PF07991.12 ETO08386.1 - 8.1e-06 25.5 0.4 1.2e-05 24.9 0.4 1.3 1 0 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain THF_DHG_CYH_C PF02882.19 ETO08386.1 - 6.4e-05 22.3 3.9 0.00053 19.3 3.9 2.1 1 1 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain Shikimate_DH PF01488.20 ETO08386.1 - 7.4e-05 22.8 0.5 0.00017 21.7 0.5 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase TrkA_N PF02254.18 ETO08386.1 - 0.00017 21.8 0.7 0.0015 18.8 0.7 2.3 1 1 0 1 1 1 1 TrkA-N domain NAD_binding_7 PF13241.6 ETO08386.1 - 0.0024 18.3 0.3 0.0048 17.3 0.3 1.5 1 0 0 1 1 1 1 Putative NAD(P)-binding ELFV_dehydrog PF00208.21 ETO08386.1 - 0.013 15.2 0.4 0.023 14.4 0.4 1.4 1 1 0 1 1 1 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 3HCDH_N PF02737.18 ETO08386.1 - 0.014 15.3 1.1 0.062 13.2 0.2 1.9 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain XdhC_C PF13478.6 ETO08386.1 - 0.024 15.1 0.0 0.035 14.6 0.0 1.2 1 0 0 1 1 1 0 XdhC Rossmann domain Gp_dh_N PF00044.24 ETO08386.1 - 0.042 14.2 0.3 0.073 13.4 0.3 1.4 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain AdoHcyase PF05221.17 ETO08387.1 - 2.1e-61 207.7 0.2 2.3e-61 207.5 0.2 1.0 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase Shisa PF13908.6 ETO08388.1 - 0.0032 17.7 0.6 0.0032 17.7 0.6 2.6 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator ODV-E18 PF10717.9 ETO08388.1 - 0.25 11.2 0.0 0.25 11.2 0.0 2.3 3 0 0 3 3 3 0 Occlusion-derived virus envelope protein ODV-E18 Comm PF15957.5 ETO08388.1 - 1.9 8.8 4.0 10 6.5 0.0 2.7 3 0 0 3 3 3 0 Commissureless AAA_9 PF12781.7 ETO08391.1 - 5.3e-05 22.5 4.9 0.017 14.2 0.2 2.2 1 1 1 2 2 2 2 ATP-binding dynein motor region WD40 PF00400.32 ETO08394.1 - 2.4e-19 69.3 15.2 5.6e-07 30.2 2.4 6.7 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08394.1 - 1.8e-08 34.5 2.2 0.0054 17.0 0.1 6.2 2 2 5 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO08394.1 - 0.0081 14.9 1.2 2.8 6.6 0.0 3.7 2 2 2 4 4 4 1 Nup133 N terminal like WD40_like PF17005.5 ETO08394.1 - 0.036 13.4 1.9 0.61 9.4 0.1 2.8 3 1 0 3 3 3 0 WD40-like domain DUF3421 PF11901.8 ETO08394.1 - 0.044 13.8 0.0 0.092 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3421) FemAB PF02388.16 ETO08394.1 - 0.17 10.7 4.0 0.25 10.2 4.0 1.2 1 0 0 1 1 1 0 FemAB family Ge1_WD40 PF16529.5 ETO08394.1 - 0.57 9.1 5.8 0.24 10.3 1.6 2.3 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein YtxC PF08812.11 ETO08395.1 - 0.015 14.9 0.4 0.02 14.5 0.4 1.1 1 0 0 1 1 1 0 YtxC-like family IL4_i_Ig PF18258.1 ETO08395.1 - 0.041 14.1 0.0 0.059 13.6 0.0 1.2 1 0 0 1 1 1 0 Interleukin-4 inducing immunoglobulin-binding domain TPR_6 PF13174.6 ETO08395.1 - 0.14 12.8 0.0 0.45 11.3 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat SecA_DEAD PF07517.14 ETO08396.1 - 2.9e-08 33.4 2.4 1.1e-07 31.4 0.0 2.9 3 1 0 3 3 3 1 SecA DEAD-like domain VWA_2 PF13519.6 ETO08396.1 - 0.0011 19.6 0.1 0.011 16.4 0.0 2.8 3 0 0 3 3 3 1 von Willebrand factor type A domain Helicase_C PF00271.31 ETO08396.1 - 0.0068 16.7 2.5 0.018 15.4 0.1 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain HD_2 PF12917.7 ETO08396.1 - 0.0091 15.8 0.6 0.0091 15.8 0.6 2.9 3 0 0 3 3 3 1 HD containing hydrolase-like enzyme VWA PF00092.28 ETO08396.1 - 0.0093 16.2 0.0 0.48 10.7 0.0 3.5 2 1 0 2 2 2 1 von Willebrand factor type A domain PRK PF00485.18 ETO08397.1 - 0.16 11.7 2.4 0.17 11.6 0.4 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family RP-C_C PF11800.8 ETO08397.1 - 1.2 9.2 4.6 1 9.4 0.7 2.8 2 0 0 2 2 2 0 Replication protein C C-terminal region Adaptin_binding PF10199.9 ETO08397.1 - 2.9 8.5 13.9 4.1 8.0 0.7 3.5 3 0 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 DUF2072 PF09845.9 ETO08397.1 - 8.9 6.6 10.3 0.17 12.1 0.8 3.1 3 0 0 3 3 3 0 Zn-ribbon containing protein Dynamin_N PF00350.23 ETO08398.1 - 0.02 14.9 0.1 0.057 13.5 0.1 1.8 1 0 0 1 1 1 0 Dynamin family Csm1_B PF18211.1 ETO08399.1 - 0.11 12.3 0.6 0.5 10.2 0.0 2.3 2 0 0 2 2 2 0 Csm1 subunit domain B DUF4407 PF14362.6 ETO08399.1 - 0.13 11.6 1.7 0.18 11.1 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) T4SS PF07996.11 ETO08399.1 - 0.15 12.4 4.4 0.22 11.9 1.7 2.2 3 0 0 3 3 3 0 Type IV secretion system proteins Golgin_A5 PF09787.9 ETO08399.1 - 0.17 11.3 8.1 0.23 10.9 8.1 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Filament PF00038.21 ETO08399.1 - 0.21 11.1 8.4 1.5 8.4 5.8 2.1 1 1 1 2 2 2 0 Intermediate filament protein DUF1664 PF07889.12 ETO08399.1 - 0.25 11.4 4.3 0.41 10.7 3.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 ETO08399.1 - 0.3 9.6 10.4 0.42 9.2 10.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A YlqD PF11068.8 ETO08399.1 - 1.2 9.5 13.0 1.2 9.5 10.0 2.2 1 1 1 2 2 2 0 YlqD protein Fib_alpha PF08702.10 ETO08399.1 - 1.7 8.8 9.1 1.1 9.4 6.2 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SpoVT_C PF15714.5 ETO08399.1 - 1.8 8.6 8.4 0.21 11.6 1.3 2.6 1 1 2 3 3 3 0 Stage V sporulation protein T C-terminal, transcription factor HIP1_clath_bdg PF16515.5 ETO08399.1 - 1.8 9.2 10.4 1.2 9.7 7.3 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4909 PF16253.5 ETO08400.1 - 0.064 13.1 2.5 0.12 12.3 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4909) MreB_Mbl PF06723.13 ETO08400.1 - 0.1 11.4 0.0 1.2 7.8 0.0 2.0 2 0 0 2 2 2 0 MreB/Mbl protein Astro_capsid_p PF12226.8 ETO08401.1 - 1.7 7.7 6.8 2.3 7.3 6.8 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Kinesin PF00225.23 ETO08402.1 - 1.3e-13 50.6 0.5 1.6e-13 50.3 0.5 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO08402.1 - 4.5e-05 23.4 0.0 0.00072 19.5 0.0 2.1 2 0 0 2 2 2 1 Microtubule binding Synaptobrevin PF00957.21 ETO08404.1 - 3e-06 26.9 3.2 3e-06 26.9 3.2 2.7 2 1 0 2 2 2 1 Synaptobrevin Longin PF13774.6 ETO08404.1 - 0.0027 17.7 2.0 0.0042 17.1 0.1 2.3 2 1 0 2 2 2 1 Regulated-SNARE-like domain SAWADEE PF16719.5 ETO08404.1 - 0.022 14.8 1.3 0.059 13.4 0.2 2.0 2 0 0 2 2 2 0 SAWADEE domain Z1 PF10593.9 ETO08404.1 - 0.22 11.0 4.6 0.061 12.8 1.1 1.8 2 0 0 2 2 2 0 Z1 domain WD40 PF00400.32 ETO08405.1 - 0.0059 17.4 0.2 7.5 7.6 0.1 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Snf7 PF03357.21 ETO08406.1 - 0.026 14.1 17.9 0.27 10.8 1.3 2.4 1 1 1 2 2 2 0 Snf7 HSBP1 PF06825.12 ETO08406.1 - 0.044 13.6 8.3 0.17 11.7 0.2 2.4 2 0 0 2 2 2 0 Heat shock factor binding protein 1 ThiF PF00899.21 ETO08406.1 - 0.11 11.9 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 ThiF family Zip PF02535.22 ETO08406.1 - 0.19 10.9 0.7 0.25 10.5 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Strabismus PF06638.11 ETO08408.1 - 3 6.4 7.2 1.9 7.1 4.7 1.7 1 1 1 2 2 2 0 Strabismus protein Kelch_6 PF13964.6 ETO08411.1 - 3.6e-06 27.1 7.8 0.0059 16.9 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO08411.1 - 0.00016 21.1 7.9 0.53 9.9 0.1 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO08411.1 - 0.0032 17.5 4.2 0.014 15.4 0.3 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08411.1 - 0.15 12.1 5.9 2.3 8.3 0.1 3.7 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO08411.1 - 0.19 11.7 0.1 0.19 11.7 0.1 3.3 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO08412.1 - 1.9e-12 47.5 0.6 2.1e-09 37.8 0.0 3.6 3 1 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08412.1 - 1.1e-06 28.8 0.2 0.0055 17.0 0.0 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08412.1 - 0.0041 16.5 0.3 0.0063 15.9 0.3 1.2 1 0 0 1 1 1 1 WD40-like domain WD40 PF00400.32 ETO08413.1 - 5.2e-13 49.2 6.0 6.7e-05 23.6 0.0 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08413.1 - 0.00026 21.2 0.2 4.7 7.6 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08413.1 - 0.00051 18.8 1.4 0.94 8.0 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 SKA2 PF16740.5 ETO08414.1 - 0.0075 16.0 1.7 0.01 15.6 1.7 1.2 1 0 0 1 1 1 1 Spindle and kinetochore-associated protein 2 zf-PARP PF00645.18 ETO08414.1 - 0.035 15.0 1.4 0.049 14.5 1.4 1.2 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region MLANA PF14991.6 ETO08414.1 - 0.049 13.9 1.2 0.055 13.8 1.2 1.2 1 0 0 1 1 1 0 Protein melan-A RVT_1 PF00078.27 ETO08416.1 - 4e-05 23.2 0.1 9.9e-05 21.9 0.1 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) LRAT PF04970.13 ETO08416.1 - 0.037 14.3 0.8 0.093 13.0 0.1 2.1 2 0 0 2 2 2 0 Lecithin retinol acyltransferase Exo_endo_phos_2 PF14529.6 ETO08417.1 - 3.6e-15 55.9 1.1 3.6e-15 55.9 1.1 2.4 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase eIF3m_C_helix PF18005.1 ETO08417.1 - 0.022 14.5 0.5 0.046 13.4 0.5 1.6 1 0 0 1 1 1 0 eIF3 subunit M, C-terminal helix Exo_endo_phos PF03372.23 ETO08417.1 - 0.034 13.6 0.2 0.06 12.8 0.0 1.6 2 0 0 2 2 2 0 Endonuclease/Exonuclease/phosphatase family Peptidase_C36 PF05415.11 ETO08417.1 - 0.12 12.7 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase Vert_IL3-reg_TF PF06529.11 ETO08417.1 - 0.6 9.2 4.2 0.52 9.4 2.9 1.7 1 1 0 1 1 1 0 Vertebrate interleukin-3 regulated transcription factor WD40 PF00400.32 ETO08419.1 - 1.7e-08 35.0 7.1 4.2e-08 33.7 2.2 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO08419.1 - 5.9e-05 21.9 0.2 8.6e-05 21.4 0.2 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08419.1 - 0.021 15.1 0.1 0.04 14.2 0.1 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain BLF1 PF17752.1 ETO08419.1 - 0.032 13.5 0.2 0.036 13.4 0.2 1.1 1 0 0 1 1 1 0 Burkholderia lethal factor 1 EF-hand_1 PF00036.32 ETO08423.1 - 0.003 17.0 0.0 0.0069 15.9 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ETO08423.1 - 0.0038 16.7 0.0 0.0072 15.8 0.0 1.5 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO08423.1 - 0.023 15.2 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO08423.1 - 0.025 14.5 0.0 0.067 13.2 0.0 1.7 1 0 0 1 1 1 0 EF-hand domain Com_YlbF PF06133.11 ETO08423.1 - 0.11 13.1 4.9 0.17 12.5 4.9 1.3 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA TPR_12 PF13424.6 ETO08424.1 - 7.9e-120 391.4 28.6 5e-24 84.4 0.1 6.6 1 1 6 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO08424.1 - 9.9e-89 289.1 0.3 4.7e-12 45.4 0.0 9.0 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO08424.1 - 7.3e-62 202.8 54.2 7.5e-11 41.4 0.8 9.3 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO08424.1 - 1.2e-59 194.0 15.7 8.3e-09 34.9 0.0 8.6 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO08424.1 - 1.8e-53 174.4 37.5 3.7e-08 32.9 0.2 9.2 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO08424.1 - 8.7e-51 165.9 57.6 4e-09 36.0 1.2 8.8 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO08424.1 - 2.9e-35 118.1 10.0 0.00014 22.0 0.1 9.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_16 PF13432.6 ETO08424.1 - 2.5e-34 117.7 0.0 0.00051 20.6 0.0 8.5 7 2 1 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO08424.1 - 3e-22 77.4 0.0 0.069 14.0 0.0 8.1 8 1 1 9 9 8 4 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO08424.1 - 4e-22 79.0 0.0 2.5e-07 30.4 0.0 3.1 1 1 2 3 3 3 3 MalT-like TPR region TPR_6 PF13174.6 ETO08424.1 - 1.6e-18 66.0 14.3 0.062 14.0 0.2 8.9 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO08424.1 - 2.7e-16 59.0 60.5 8.5e-06 25.4 4.1 11.5 7 3 4 11 11 11 7 TPR repeat PPR PF01535.20 ETO08424.1 - 1.8e-15 56.0 21.4 0.065 13.5 0.2 8.5 9 0 0 9 9 8 4 PPR repeat DUF5113 PF17140.4 ETO08424.1 - 3.5e-13 49.7 23.8 0.19 11.5 0.0 7.6 6 1 2 8 8 8 5 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO08424.1 - 6.2e-13 49.0 7.0 0.025 15.1 0.1 5.9 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_3 PF07720.12 ETO08424.1 - 1.9e-11 43.7 43.3 0.27 11.3 0.1 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat MIT PF04212.18 ETO08424.1 - 5.1e-07 29.7 44.4 0.068 13.3 0.4 8.4 9 0 0 9 9 9 3 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO08424.1 - 1.6e-05 25.0 24.1 0.079 13.2 2.6 6.7 1 1 7 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO08424.1 - 1.9e-05 25.1 14.5 6.4 7.4 0.4 7.3 5 3 0 5 5 5 0 Domain of unknown function (DUF4810) OrfA PF17495.2 ETO08424.1 - 3.5e-05 23.9 0.0 18 5.6 0.0 5.5 2 1 2 5 5 5 0 Vpr-like OrfA RPN7 PF10602.9 ETO08424.1 - 6.9e-05 22.6 21.3 0.16 11.7 0.3 6.7 1 1 5 7 7 7 1 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 ETO08424.1 - 7.5e-05 22.1 12.9 0.74 9.3 0.0 6.4 7 0 0 7 7 6 2 SHNi-TPR Ten1_2 PF15490.6 ETO08424.1 - 0.00023 20.8 0.0 21 4.9 0.0 5.1 1 1 2 5 5 5 0 Telomere-capping, CST complex subunit TPR_21 PF09976.9 ETO08424.1 - 0.00028 20.7 16.6 0.0021 17.8 0.6 5.6 1 1 2 4 4 4 1 Tetratricopeptide repeat-like domain Pep3_Vps18 PF05131.14 ETO08424.1 - 0.00049 19.9 6.3 15 5.4 0.0 6.5 7 0 0 7 7 7 0 Pep3/Vps18/deep orange family DUF3856 PF12968.7 ETO08424.1 - 0.00086 19.4 7.5 8.1 6.5 0.1 5.0 1 1 4 5 5 5 0 Domain of Unknown Function (DUF3856) TPR_9 PF13371.6 ETO08424.1 - 0.0022 18.1 0.0 0.78 9.9 0.0 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO08424.1 - 0.034 13.7 14.1 3.3 7.4 0.0 7.3 7 2 1 8 8 8 0 Helix-turn-helix bacterial domain Sel1 PF08238.12 ETO08424.1 - 0.035 14.8 25.9 19 6.1 0.4 8.9 9 1 0 9 9 9 0 Sel1 repeat Mob_Pre PF01076.19 ETO08424.1 - 0.045 13.6 14.2 1.8 8.3 0.1 4.8 2 1 3 5 5 5 0 Plasmid recombination enzyme Clathrin PF00637.20 ETO08424.1 - 0.12 12.2 15.2 4.2 7.2 0.6 5.9 3 2 0 3 3 3 0 Region in Clathrin and VPS FATC PF02260.20 ETO08424.1 - 0.15 11.9 4.0 1.2e+02 2.6 0.0 4.7 5 0 0 5 5 5 0 FATC domain DUF2225 PF09986.9 ETO08424.1 - 0.33 10.6 26.0 4 7.1 0.5 5.0 1 1 2 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2225) TetR_C_19 PF17924.1 ETO08424.1 - 0.34 11.5 10.0 59 4.3 0.0 5.5 6 1 0 6 6 5 0 Tetracyclin repressor-like, C-terminal domain DUF3450 PF11932.8 ETO08424.1 - 0.38 10.0 14.8 10 5.3 0.1 5.5 1 1 5 6 6 6 0 Protein of unknown function (DUF3450) PPR_2 PF13041.6 ETO08424.1 - 5.3 7.3 17.5 56 4.0 0.0 6.9 9 0 0 9 9 7 0 PPR repeat family DUF627 PF04781.12 ETO08424.1 - 6.2 6.9 18.9 25 4.9 0.1 6.4 5 4 3 8 8 8 0 Protein of unknown function (DUF627) zf-TRAF PF02176.18 ETO08426.1 - 4.5e-05 24.1 1.7 4.5e-05 24.1 1.7 2.5 1 1 1 2 2 2 1 TRAF-type zinc finger WD40 PF00400.32 ETO08426.1 - 0.00028 21.6 0.6 0.00081 20.2 0.6 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat WD40 PF00400.32 ETO08427.1 - 3e-11 43.7 3.4 6.1e-09 36.4 0.1 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Roc PF08477.13 ETO08427.1 - 0.00011 22.3 4.3 0.16 12.2 0.2 2.6 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Ge1_WD40 PF16529.5 ETO08427.1 - 0.0015 17.6 0.4 0.0017 17.4 0.4 1.1 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO08427.1 - 0.0063 16.8 0.4 0.43 10.9 0.1 3.2 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO08429.1 - 1.8e-14 53.8 9.2 0.0004 21.1 0.3 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08429.1 - 0.074 13.4 0.3 3.1 8.2 0.0 2.7 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08429.1 - 0.29 9.7 1.8 2.6 6.6 0.1 2.6 2 1 0 3 3 3 0 Nucleoporin Nup120/160 bZIP_1 PF00170.21 ETO08430.1 - 0.00068 19.7 1.7 0.00068 19.7 1.7 2.5 3 0 0 3 3 3 1 bZIP transcription factor MAGSP PF03082.14 ETO08430.1 - 0.0013 18.4 1.3 0.0015 18.2 1.3 1.2 1 0 0 1 1 1 1 Male accessory gland secretory protein YabA PF06156.13 ETO08430.1 - 0.0028 18.3 1.5 0.0036 17.9 1.5 1.3 1 0 0 1 1 1 1 Initiation control protein YabA KASH_CCD PF14662.6 ETO08430.1 - 0.0036 17.2 5.6 0.0042 16.9 5.6 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DivIC PF04977.15 ETO08430.1 - 0.004 16.9 1.1 0.0087 15.8 1.1 1.6 1 0 0 1 1 1 1 Septum formation initiator Tho2 PF11262.8 ETO08430.1 - 0.0068 15.7 2.2 0.0085 15.3 2.2 1.1 1 0 0 1 1 1 1 Transcription factor/nuclear export subunit protein 2 DUF465 PF04325.13 ETO08430.1 - 0.0068 16.4 1.9 0.016 15.2 0.0 2.5 3 0 0 3 3 3 1 Protein of unknown function (DUF465) TSC22 PF01166.18 ETO08430.1 - 0.018 15.4 2.3 3.8 7.9 0.4 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family TMCO5 PF14992.6 ETO08430.1 - 0.029 14.0 4.8 0.033 13.8 4.8 1.2 1 0 0 1 1 1 0 TMCO5 family Cnn_1N PF07989.11 ETO08430.1 - 0.041 14.1 4.0 0.046 13.9 1.4 2.2 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DUF4829 PF16111.5 ETO08430.1 - 0.21 12.4 6.2 0.27 12.0 6.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4829) Ank_5 PF13857.6 ETO08431.1 - 2.3e-06 27.8 0.0 4.3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) CEL_III_C PF18054.1 ETO08431.1 - 0.0012 18.9 0.2 0.0017 18.5 0.2 1.3 1 0 0 1 1 1 1 CEL-III C-terminal Ank_2 PF12796.7 ETO08431.1 - 0.0038 17.8 0.0 0.0071 16.9 0.0 1.7 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO08431.1 - 0.0067 16.8 0.2 0.29 11.8 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeat Ceramidase PF05875.12 ETO08431.1 - 0.0099 15.3 2.5 1.2 8.5 0.1 2.1 2 0 0 2 2 2 2 Ceramidase Ank_4 PF13637.6 ETO08431.1 - 0.015 15.8 0.3 0.046 14.3 0.2 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) TMEM220 PF15071.6 ETO08431.1 - 0.02 15.7 0.1 8.6 7.2 0.0 2.3 2 0 0 2 2 2 0 Transmembrane family 220, helix SH3_1 PF00018.28 ETO08432.1 - 5.1e-05 22.8 0.0 0.00012 21.6 0.0 1.6 1 0 0 1 1 1 1 SH3 domain DUF1878 PF08963.10 ETO08432.1 - 0.0016 18.9 0.5 0.13 12.8 0.1 2.4 1 1 1 2 2 2 2 Protein of unknown function (DUF1878) SH3_2 PF07653.17 ETO08432.1 - 0.083 12.6 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 Variant SH3 domain RasGEF PF00617.19 ETO08433.1 - 1.2e-54 185.2 1.7 2.1e-54 184.4 1.7 1.4 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETO08433.1 - 0.00076 19.7 1.2 0.002 18.4 0.4 2.2 2 0 0 2 2 2 1 RasGEF N-terminal motif PUB PF09409.10 ETO08434.1 - 6.7e-08 32.4 0.0 1.4e-07 31.4 0.0 1.6 1 0 0 1 1 1 1 PUB domain dsrm PF00035.26 ETO08434.1 - 0.99 10.2 3.6 1.2 9.9 0.1 2.7 3 0 0 3 3 3 0 Double-stranded RNA binding motif KxDL PF10241.9 ETO08435.1 - 0.028 14.7 7.4 0.028 14.7 7.4 4.2 3 1 1 4 4 4 0 Uncharacterized conserved protein MerR-DNA-bind PF09278.11 ETO08435.1 - 0.54 10.8 0.1 0.54 10.8 0.1 3.8 3 1 2 5 5 5 0 MerR, DNA binding MCPsignal PF00015.21 ETO08435.1 - 5.5 6.8 9.9 0.75 9.6 1.7 2.6 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain WD40 PF00400.32 ETO08437.1 - 6.6e-58 191.3 19.2 4.9e-10 39.8 0.1 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08437.1 - 1.2e-21 76.8 2.0 0.00085 19.6 0.0 6.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08437.1 - 1.5e-11 44.2 1.2 0.0029 17.0 0.0 3.5 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO08437.1 - 1.9e-10 40.0 4.7 0.086 11.5 0.0 5.1 2 2 3 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO08437.1 - 2.5e-10 39.8 0.4 0.06 12.3 0.0 5.3 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO08437.1 - 0.00023 19.8 0.4 0.0045 15.6 0.1 2.4 1 1 2 3 3 3 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO08437.1 - 0.0011 18.4 1.2 7.6 5.8 0.0 4.1 1 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO08437.1 - 0.0012 18.7 5.6 4.6 7.3 0.1 5.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO08437.1 - 0.008 16.2 0.0 0.16 12.0 0.0 2.8 2 0 0 2 2 2 1 Family of unknown function (DUF5474) Kelch_5 PF13854.6 ETO08437.1 - 0.01 15.8 0.7 0.026 14.5 0.7 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_2 PF07646.15 ETO08437.1 - 0.011 15.7 0.7 0.19 11.8 0.3 3.1 2 0 0 2 2 2 0 Kelch motif DPPIV_N PF00930.21 ETO08437.1 - 0.013 14.2 0.0 18 4.0 0.0 3.6 2 2 2 5 5 5 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Kelch_4 PF13418.6 ETO08437.1 - 0.021 14.8 0.9 0.11 12.5 0.1 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain PALB2_WD40 PF16756.5 ETO08437.1 - 0.033 13.1 3.1 7.2 5.4 0.0 4.1 1 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Kelch_6 PF13964.6 ETO08437.1 - 0.041 14.2 0.2 0.041 14.2 0.2 3.2 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO08437.1 - 0.15 11.7 2.2 0.16 11.5 0.2 2.2 2 0 0 2 2 2 0 Kelch motif Proteasome_A_N PF10584.9 ETO08437.1 - 5.5 6.8 12.2 6.7 6.5 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature zf-RING_2 PF13639.6 ETO08438.1 - 1.9e-13 50.5 11.1 5.4e-13 49.0 11.1 1.9 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO08438.1 - 1e-08 34.8 9.0 2.3e-08 33.6 9.0 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO08438.1 - 4.5e-08 32.8 10.8 1.8e-07 30.9 10.8 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO08438.1 - 6.6e-08 32.7 9.4 6.6e-08 32.7 9.4 2.8 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO08438.1 - 7e-07 29.0 11.1 2.3e-06 27.4 11.1 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO08438.1 - 9.7e-06 25.5 8.9 3e-05 23.9 8.9 2.0 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO08438.1 - 2.2e-05 24.3 11.0 5.9e-05 23.0 11.0 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ETO08438.1 - 5.6e-05 22.9 9.5 0.00011 21.9 9.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO08438.1 - 6.7e-05 22.9 4.9 0.00018 21.5 4.9 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO08438.1 - 0.0031 17.3 7.6 0.01 15.7 7.6 2.0 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ETO08438.1 - 0.0057 16.3 9.1 0.013 15.1 9.1 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-C3H2C3 PF17122.5 ETO08438.1 - 0.25 11.4 8.5 0.73 9.9 8.5 1.9 1 0 0 1 1 1 0 Zinc-finger zf-RING-like PF08746.11 ETO08438.1 - 2 8.8 10.9 6.3 7.2 10.9 1.9 1 0 0 1 1 1 0 RING-like domain zf-Nse PF11789.8 ETO08438.1 - 5 7.0 9.8 1.4 8.8 6.0 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit LapA_dom PF06305.11 ETO08439.1 - 0.0041 16.9 2.4 0.02 14.7 2.4 1.9 1 1 0 1 1 1 1 Lipopolysaccharide assembly protein A domain MadL PF03817.13 ETO08439.1 - 0.65 10.0 5.2 0.89 9.6 5.2 1.2 1 0 0 1 1 1 0 Malonate transporter MadL subunit PX PF00787.24 ETO08440.1 - 1.3e-07 31.6 0.6 2.1e-07 30.9 0.6 1.3 1 0 0 1 1 1 1 PX domain CAF1 PF04857.20 ETO08440.1 - 0.036 13.3 0.1 0.04 13.1 0.1 1.1 1 0 0 1 1 1 0 CAF1 family ribonuclease Gpi16 PF04113.14 ETO08441.1 - 1.7e-05 23.5 0.1 2.3e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component IL6 PF00489.17 ETO08441.1 - 0.0018 17.9 3.3 0.0024 17.4 3.3 1.2 1 0 0 1 1 1 1 Interleukin-6/G-CSF/MGF family DUF5046 PF16465.5 ETO08441.1 - 0.0019 17.7 0.0 0.0029 17.1 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5046) DAGK_cat PF00781.24 ETO08441.1 - 0.072 12.7 0.0 0.2 11.2 0.0 1.9 1 1 0 1 1 1 0 Diacylglycerol kinase catalytic domain ODV-E18 PF10717.9 ETO08442.1 - 0.32 10.9 2.7 10 6.1 0.1 3.1 4 0 0 4 4 4 0 Occlusion-derived virus envelope protein ODV-E18 UBX PF00789.20 ETO08443.1 - 9.3e-10 38.6 0.1 2.7e-09 37.1 0.1 1.8 1 0 0 1 1 1 1 UBX domain UBA_4 PF14555.6 ETO08443.1 - 7.6e-08 32.0 1.4 1.6e-07 31.0 1.4 1.5 1 0 0 1 1 1 1 UBA-like domain Glyco_hydro_45 PF02015.16 ETO08443.1 - 0.0063 16.5 1.8 0.01 15.8 0.6 1.8 2 0 0 2 2 2 1 Glycosyl hydrolase family 45 TAP_C PF03943.13 ETO08443.1 - 0.13 11.9 0.7 0.3 10.8 0.7 1.5 1 0 0 1 1 1 0 TAP C-terminal domain DUF4525 PF15027.6 ETO08444.1 - 0.031 14.0 0.1 0.056 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4525) CLIP_SPH_mas PF18398.1 ETO08444.1 - 0.92 10.0 3.2 0.99 9.9 0.0 2.5 3 0 0 3 3 3 0 Clip-domain serine protease homolog masquerade Glyco_hydro_19 PF00182.19 ETO08445.1 - 0.024 14.5 0.1 0.079 12.8 0.0 1.7 2 0 0 2 2 2 0 Chitinase class I DNA_pol_delta_4 PF04081.13 ETO08445.1 - 0.83 10.0 8.2 0.17 12.2 1.0 2.3 2 0 0 2 2 2 0 DNA polymerase delta, subunit 4 TMEM51 PF15345.6 ETO08445.1 - 1.5 8.6 7.2 1.7 8.4 5.6 1.9 1 1 1 2 2 2 0 Transmembrane protein 51 WD40 PF00400.32 ETO08446.1 - 1.2e-38 130.4 17.7 1.4e-08 35.2 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08446.1 - 1.7e-15 57.1 2.8 0.013 15.8 0.0 4.5 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08446.1 - 1.1e-09 37.7 2.5 0.45 9.4 0.0 4.9 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO08446.1 - 1.7e-06 27.0 2.2 0.019 13.6 0.3 3.7 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08446.1 - 3.7e-05 23.2 5.1 0.0055 16.1 0.2 2.1 2 0 0 2 2 2 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO08446.1 - 0.00037 19.7 1.4 0.023 13.7 0.2 2.4 1 1 2 3 3 3 2 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO08446.1 - 0.0031 16.3 6.4 0.45 9.2 0.4 2.8 1 1 2 3 3 3 2 Nup133 N terminal like DUF5021 PF16424.5 ETO08446.1 - 0.013 15.4 0.0 5.2 6.9 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5021) PD40 PF07676.12 ETO08446.1 - 0.19 11.7 5.1 21 5.2 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Mo25 PF08569.11 ETO08447.1 - 1.3e-119 399.4 20.9 1.9e-119 398.9 20.9 1.2 1 0 0 1 1 1 1 Mo25-like AOX PF01786.17 ETO08447.1 - 0.044 13.3 0.0 0.089 12.4 0.0 1.5 1 0 0 1 1 1 0 Alternative oxidase DTC PF18102.1 ETO08449.1 - 1.4e-50 170.9 3.7 2.8e-50 169.9 0.1 2.6 2 0 0 2 2 2 1 Deltex C-terminal domain zf-rbx1 PF12678.7 ETO08449.1 - 4.7e-07 30.0 2.1 4.7e-07 30.0 2.1 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETO08449.1 - 1.4e-05 25.3 7.1 0.00025 21.3 2.7 2.8 2 0 0 2 2 2 1 Ring finger domain WWE PF02825.20 ETO08449.1 - 5.6e-05 23.7 0.5 5.6e-05 23.7 0.5 3.3 4 0 0 4 4 4 1 WWE domain zf-C3HC4_2 PF13923.6 ETO08449.1 - 0.00083 19.1 4.3 0.0037 17.1 0.7 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO08449.1 - 0.0019 17.9 1.3 1.3 8.9 0.1 3.0 2 0 0 2 2 2 2 RING-like zinc finger zf-ANAPC11 PF12861.7 ETO08449.1 - 0.002 18.1 2.2 0.0032 17.5 0.8 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4 PF00097.25 ETO08449.1 - 0.016 15.1 4.4 0.4 10.6 0.8 2.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO08449.1 - 0.02 14.9 4.2 0.2 11.6 2.1 2.7 2 0 0 2 2 2 0 zinc-RING finger domain TP_methylase PF00590.20 ETO08450.1 - 2.2e-21 76.8 0.0 3.2e-21 76.3 0.0 1.2 1 0 0 1 1 1 1 Tetrapyrrole (Corrin/Porphyrin) Methylases Ribosomal_L5_C PF00673.21 ETO08450.1 - 2.9e-12 46.6 0.0 1.8e-11 44.0 0.0 2.3 2 0 0 2 2 2 1 ribosomal L5P family C-terminus TP_methylase PF00590.20 ETO08451.1 - 0.089 12.7 0.4 0.21 11.5 0.0 1.7 2 0 0 2 2 2 0 Tetrapyrrole (Corrin/Porphyrin) Methylases Seadorna_VP6 PF07407.11 ETO08451.1 - 0.091 11.7 0.1 0.097 11.6 0.1 1.1 1 0 0 1 1 1 0 Seadornavirus VP6 protein WD40 PF00400.32 ETO08452.1 - 2.5e-26 91.4 29.3 2.2e-06 28.3 3.4 7.0 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08452.1 - 8e-10 38.9 2.1 0.11 12.8 0.0 5.2 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08452.1 - 0.00074 18.3 8.6 1.7 7.2 0.2 4.3 2 2 3 5 5 5 4 Nucleoporin Nup120/160 CRM1_C PF08767.11 ETO08453.1 - 2.8e-16 59.6 0.8 4e-16 59.1 0.8 1.2 1 0 0 1 1 1 1 CRM1 C terminal DUF4521 PF15021.6 ETO08453.1 - 0.013 15.4 0.0 0.02 14.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4521) 7TM_GPCR_Str PF10326.9 ETO08454.1 - 0.18 11.1 0.0 0.24 10.7 0.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Str 7TM_GPCR_Srj PF10319.9 ETO08454.1 - 0.29 10.4 0.0 0.38 10.0 0.0 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srj Mo25 PF08569.11 ETO08455.1 - 0.013 14.9 0.1 0.017 14.5 0.1 1.2 1 0 0 1 1 1 0 Mo25-like AP3D1 PF06375.11 ETO08455.1 - 0.37 11.0 4.4 0.17 12.1 1.1 1.9 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Peptidase_S49_N PF08496.10 ETO08456.1 - 2.5 8.1 8.9 2.3 8.3 1.7 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Med8 PF10232.9 ETO08457.1 - 1e-05 25.3 0.4 1e-05 25.3 0.4 1.9 1 1 1 2 2 2 1 Mediator of RNA polymerase II transcription complex subunit 8 DUF2802 PF10975.8 ETO08457.1 - 7.1 6.8 6.6 6 7.1 0.1 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2802) zf-C3HC4 PF00097.25 ETO08458.1 - 7.7e-08 32.1 15.4 2.3e-07 30.6 15.4 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO08458.1 - 4.1e-07 29.8 15.2 4.1e-07 29.8 15.2 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO08458.1 - 4.1e-07 30.2 14.0 1.2e-06 28.8 14.0 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_4 PF15227.6 ETO08458.1 - 5.9e-06 26.3 13.0 8.1e-06 25.9 10.4 2.4 1 1 1 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ETO08458.1 - 2.8e-05 24.1 8.7 2.8e-05 24.1 8.7 3.0 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO08458.1 - 0.00011 22.0 17.5 0.00018 21.3 16.0 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO08458.1 - 0.00015 21.6 14.1 0.00047 20.0 14.1 1.9 1 0 0 1 1 1 1 zinc-RING finger domain Zip PF02535.22 ETO08458.1 - 0.03 13.5 0.7 0.033 13.4 0.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Prok-RING_4 PF14447.6 ETO08458.1 - 0.076 12.9 15.0 0.22 11.4 15.0 1.8 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Hydin_ADK PF17213.3 ETO08458.1 - 0.29 11.4 8.0 0.49 10.6 8.0 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CDC45 PF02724.14 ETO08458.1 - 0.48 8.7 14.8 0.63 8.3 14.8 1.1 1 0 0 1 1 1 0 CDC45-like protein zf-rbx1 PF12678.7 ETO08458.1 - 0.65 10.3 12.6 3.2 8.1 12.6 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain RR_TM4-6 PF06459.12 ETO08458.1 - 1.2 8.9 16.3 2.1 8.1 16.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-Nse PF11789.8 ETO08458.1 - 2.8 7.8 11.6 5.3 6.9 7.4 2.6 1 1 1 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit mTERF PF02536.14 ETO08459.1 - 0.032 13.2 0.4 0.26 10.2 0.4 2.1 1 1 0 1 1 1 0 mTERF 2OG-FeII_Oxy_2 PF13532.6 ETO08460.1 - 1.2e-08 35.4 0.0 1.7e-08 34.9 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SAM_1 PF00536.30 ETO08461.1 - 0.0026 18.2 0.5 0.021 15.3 0.2 2.4 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) Pkinase PF00069.25 ETO08462.1 - 1.9e-45 155.3 0.2 2e-45 155.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08462.1 - 2.8e-21 76.0 0.0 4e-21 75.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO08462.1 - 0.00013 21.4 0.0 0.00023 20.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO08462.1 - 0.022 14.1 0.0 0.035 13.4 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO08462.1 - 0.026 14.4 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family FTA2 PF13095.6 ETO08462.1 - 0.03 13.9 0.0 0.049 13.3 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 WD40 PF00400.32 ETO08463.1 - 3.7e-12 46.6 9.7 0.00014 22.5 0.2 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO08463.1 - 0.0023 16.6 0.8 0.46 9.1 0.1 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08463.1 - 0.0025 18.1 0.3 3.4 8.0 0.1 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO08465.1 - 5.5e-31 106.1 23.4 2.9e-08 34.2 0.9 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08465.1 - 2.8e-13 50.0 0.4 0.00017 21.8 0.0 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08465.1 - 2.8e-08 32.9 9.4 0.0043 15.8 0.3 5.0 1 1 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08465.1 - 6.2e-07 29.0 5.2 0.00014 21.3 1.6 3.3 1 1 2 3 3 3 2 WD40-like domain FAM76 PF16046.5 ETO08465.1 - 0.0054 16.1 12.7 0.0054 16.1 12.7 2.3 1 1 2 3 3 3 1 FAM76 protein APG17 PF04108.12 ETO08465.1 - 0.014 14.6 5.1 0.018 14.2 5.1 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 CEP63 PF17045.5 ETO08465.1 - 0.023 14.6 9.0 0.036 14.0 9.0 1.3 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa DUF4570 PF15134.6 ETO08465.1 - 0.033 14.2 4.7 0.066 13.2 4.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4570) Nmad5 PF18757.1 ETO08465.1 - 0.15 12.2 3.0 0.27 11.4 3.0 1.5 1 1 0 1 1 1 0 Nucleotide modification associated domain 5 CCDC144C PF14915.6 ETO08465.1 - 0.65 9.1 16.9 1 8.4 16.9 1.3 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region DUF1635 PF07795.11 ETO08465.1 - 1.7 8.5 7.4 3.1 7.6 7.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) PALP PF00291.25 ETO08466.1 - 0.12 11.8 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme tRNA-Thr_ED PF08915.11 ETO08467.1 - 2.4 8.2 7.6 2.5 8.1 5.4 2.1 1 1 1 2 2 2 0 Archaea-specific editing domain of threonyl-tRNA synthetase WD40 PF00400.32 ETO08468.1 - 1.3e-22 79.7 21.3 3.5e-06 27.6 2.4 5.8 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO08468.1 - 1.2e-08 34.1 1.0 0.026 13.2 0.1 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08468.1 - 1.7e-07 31.4 0.2 0.069 13.5 0.0 3.9 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08468.1 - 0.00025 20.5 0.6 0.037 13.4 0.2 2.4 2 0 0 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 ETO08468.1 - 0.0068 16.4 0.1 1 9.4 0.0 2.5 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region Kelch_2 PF07646.15 ETO08468.1 - 0.046 13.7 0.6 0.42 10.7 0.1 2.7 2 0 0 2 2 2 0 Kelch motif Peptidase_C14 PF00656.22 ETO08469.1 - 5.2e-09 36.4 2.0 2.6e-08 34.2 2.0 1.8 1 1 0 1 1 1 1 Caspase domain Presenilin PF01080.17 ETO08470.1 - 0.033 12.9 6.8 0.037 12.8 6.8 1.1 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO08470.1 - 0.079 11.7 12.0 0.11 11.3 12.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO08470.1 - 0.62 9.2 3.8 0.8 8.9 3.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO08470.1 - 1.7 6.8 16.1 2.4 6.4 16.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO08470.1 - 2 6.7 10.8 3.4 5.9 10.8 1.3 1 0 0 1 1 1 0 Menin DUF3807 PF12720.7 ETO08470.1 - 2.2 8.5 19.2 3.7 7.8 19.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) ICA69 PF04629.14 ETO08470.1 - 2.7 8.3 19.8 5.6 7.2 19.8 1.4 1 0 0 1 1 1 0 Islet cell autoantigen ICA69, C-terminal domain AAA PF00004.29 ETO08471.1 - 0.0019 18.6 0.1 0.0035 17.8 0.1 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO08471.1 - 0.018 15.0 0.0 0.045 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO08471.1 - 0.14 12.6 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 ABC transporter Peptidase_M1 PF01433.20 ETO08472.1 - 2.8e-52 177.4 0.6 4.2e-52 176.9 0.6 1.2 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ETO08472.1 - 3e-20 73.2 0.3 2.3e-19 70.3 0.3 2.0 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain WLM PF08325.10 ETO08472.1 - 0.14 12.3 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 WLM domain Yippee-Mis18 PF03226.14 ETO08474.1 - 1.4e-11 44.5 0.9 3.1e-11 43.4 0.9 1.5 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C4H2 PF10146.9 ETO08474.1 - 4e-05 24.0 6.1 5.4e-05 23.6 6.1 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein FAM76 PF16046.5 ETO08474.1 - 6.3e-05 22.5 10.0 6.3e-05 22.5 10.0 1.7 1 1 0 1 1 1 1 FAM76 protein ERM PF00769.19 ETO08474.1 - 0.00017 21.5 10.0 0.00021 21.2 10.0 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family AIP3 PF03915.13 ETO08474.1 - 0.00032 19.9 6.9 0.00043 19.5 6.9 1.1 1 0 0 1 1 1 1 Actin interacting protein 3 Spc7 PF08317.11 ETO08474.1 - 0.0006 18.8 12.9 0.00083 18.3 12.9 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 ETO08474.1 - 0.00098 19.3 14.2 0.0015 18.7 14.2 1.3 1 0 0 1 1 1 1 Seryl-tRNA synthetase N-terminal domain LUC7 PF03194.15 ETO08474.1 - 0.0012 18.6 4.2 0.0015 18.3 4.2 1.2 1 0 0 1 1 1 1 LUC7 N_terminus Golgin_A5 PF09787.9 ETO08474.1 - 0.0034 16.9 12.2 0.0056 16.2 12.2 1.3 1 0 0 1 1 1 1 Golgin subfamily A member 5 HMMR_N PF15905.5 ETO08474.1 - 0.0035 16.9 14.8 0.0063 16.0 14.8 1.5 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal V_ATPase_I PF01496.19 ETO08474.1 - 0.0036 15.3 6.6 0.0041 15.1 6.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family GAS PF13851.6 ETO08474.1 - 0.0039 16.6 22.5 0.13 11.6 9.9 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding EzrA PF06160.12 ETO08474.1 - 0.0039 15.4 11.4 0.0061 14.8 11.4 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Fez1 PF06818.15 ETO08474.1 - 0.0044 17.5 13.3 0.0062 17.0 13.3 1.2 1 0 0 1 1 1 1 Fez1 Baculo_PEP_C PF04513.12 ETO08474.1 - 0.0047 17.0 2.3 0.0075 16.3 2.3 1.2 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus TACC_C PF05010.14 ETO08474.1 - 0.0051 16.6 16.7 0.015 15.1 16.7 1.7 1 1 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF16 PF01519.16 ETO08474.1 - 0.0057 17.1 5.4 0.0057 17.1 5.4 2.3 1 1 1 2 2 2 1 Protein of unknown function DUF16 Filament PF00038.21 ETO08474.1 - 0.0071 16.0 11.4 0.0098 15.5 11.4 1.3 1 0 0 1 1 1 1 Intermediate filament protein GFA PF04828.14 ETO08474.1 - 0.0073 16.6 3.9 0.57 10.6 0.1 3.2 2 1 1 3 3 3 1 Glutathione-dependent formaldehyde-activating enzyme ZapB PF06005.12 ETO08474.1 - 0.01 16.2 18.9 0.22 12.0 6.6 2.3 1 1 1 2 2 2 0 Cell division protein ZapB UPF0242 PF06785.11 ETO08474.1 - 0.011 15.9 13.4 0.016 15.3 13.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF724 PF05266.14 ETO08474.1 - 0.011 15.6 14.0 0.011 15.6 14.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Suppressor_APC PF11414.8 ETO08474.1 - 0.014 15.4 2.4 0.014 15.4 2.4 1.9 2 0 0 2 2 1 0 Adenomatous polyposis coli tumour suppressor protein Laminin_I PF06008.14 ETO08474.1 - 0.015 15.0 12.4 0.022 14.5 12.4 1.3 1 0 0 1 1 1 0 Laminin Domain I Lebercilin PF15619.6 ETO08474.1 - 0.016 14.9 14.2 0.023 14.4 14.2 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Cor1 PF04803.12 ETO08474.1 - 0.017 15.3 13.7 0.017 15.3 13.7 1.6 2 0 0 2 2 1 0 Cor1/Xlr/Xmr conserved region Cas_DxTHG PF09455.10 ETO08474.1 - 0.017 14.7 2.8 0.016 14.8 2.8 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family APG6_N PF17675.1 ETO08474.1 - 0.022 15.3 19.9 0.39 11.2 20.0 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region IFT57 PF10498.9 ETO08474.1 - 0.026 13.5 10.9 0.034 13.1 10.9 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF1492 PF07374.11 ETO08474.1 - 0.029 14.5 2.0 0.056 13.6 2.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) HBM PF16591.5 ETO08474.1 - 0.032 13.7 5.5 0.049 13.0 5.5 1.3 1 0 0 1 1 1 0 Helical bimodular sensor domain HAUS5 PF14817.6 ETO08474.1 - 0.034 12.9 8.9 0.043 12.6 8.9 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 DivIC PF04977.15 ETO08474.1 - 0.048 13.4 14.1 0.55 10.0 1.4 2.6 1 1 1 2 2 2 0 Septum formation initiator WEMBL PF05701.11 ETO08474.1 - 0.05 12.3 15.6 0.024 13.3 7.3 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light AAA_13 PF13166.6 ETO08474.1 - 0.059 12.0 12.4 0.077 11.6 12.4 1.1 1 0 0 1 1 1 0 AAA domain DUF3584 PF12128.8 ETO08474.1 - 0.074 10.6 11.3 0.095 10.2 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4618 PF15397.6 ETO08474.1 - 0.082 12.3 14.8 0.8 9.1 14.7 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) bZIP_1 PF00170.21 ETO08474.1 - 0.12 12.5 16.3 0.52 10.4 7.3 3.1 1 1 2 3 3 2 0 bZIP transcription factor FapA PF03961.13 ETO08474.1 - 0.14 10.8 12.5 0.19 10.3 12.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3450 PF11932.8 ETO08474.1 - 0.14 11.4 14.0 0.23 10.7 13.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Rx_N PF18052.1 ETO08474.1 - 0.14 12.4 10.3 0.16 12.2 4.8 2.4 1 1 1 2 2 2 0 Rx N-terminal domain PI3K_P85_iSH2 PF16454.5 ETO08474.1 - 0.16 11.5 14.2 0.31 10.6 14.2 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain CENP-F_leu_zip PF10473.9 ETO08474.1 - 0.17 11.9 21.0 0.35 10.9 21.0 1.6 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Lar_restr_allev PF14354.6 ETO08474.1 - 0.2 12.1 2.0 12 6.4 0.0 2.5 1 1 0 2 2 2 0 Restriction alleviation protein Lar NPV_P10 PF05531.12 ETO08474.1 - 0.2 12.2 5.2 1 9.8 0.2 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_DNA_bd PF12329.8 ETO08474.1 - 0.21 11.6 23.8 0.047 13.7 10.2 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF1664 PF07889.12 ETO08474.1 - 0.21 11.6 12.3 0.083 12.9 4.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) MIS13 PF08202.11 ETO08474.1 - 0.25 10.6 10.5 0.48 9.7 10.5 1.4 1 0 0 1 1 1 0 Mis12-Mtw1 protein family zf-HYPF PF07503.12 ETO08474.1 - 0.26 11.1 2.3 5.6 6.8 0.0 2.4 2 0 0 2 2 2 0 HypF finger zf-ribbon_3 PF13248.6 ETO08474.1 - 0.26 10.7 3.5 1.7 8.1 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain Tup_N PF08581.10 ETO08474.1 - 0.27 11.5 13.2 0.087 13.1 6.4 2.4 1 1 1 2 2 2 0 Tup N-terminal DUF948 PF06103.11 ETO08474.1 - 0.33 11.2 7.2 3.1 8.1 7.2 2.1 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Macoilin PF09726.9 ETO08474.1 - 0.33 9.4 9.7 0.43 9.1 9.7 1.1 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 ETO08474.1 - 0.34 10.2 8.7 0.48 9.7 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 ETO08474.1 - 0.37 11.0 15.2 0.52 10.5 14.7 1.4 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DMPK_coil PF08826.10 ETO08474.1 - 0.37 10.9 16.6 0.62 10.2 11.1 2.5 1 1 1 2 2 2 0 DMPK coiled coil domain like SOGA PF11365.8 ETO08474.1 - 0.37 11.9 15.4 1.6 9.9 13.7 2.2 1 1 1 2 2 2 0 Protein SOGA STAT_alpha PF01017.20 ETO08474.1 - 0.45 10.4 12.0 0.77 9.6 12.0 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain JIP_LZII PF16471.5 ETO08474.1 - 0.48 10.6 18.2 0.31 11.2 1.4 3.3 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II TEX13 PF15186.6 ETO08474.1 - 0.49 10.1 9.0 0.79 9.4 9.0 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Laminin_II PF06009.12 ETO08474.1 - 0.5 10.4 12.7 0.73 9.8 12.7 1.3 1 0 0 1 1 1 0 Laminin Domain II Aminopep PF10023.9 ETO08474.1 - 0.51 9.6 6.4 0.71 9.2 6.4 1.1 1 0 0 1 1 1 0 Putative aminopeptidase KASH_CCD PF14662.6 ETO08474.1 - 0.51 10.1 19.8 1 9.1 19.8 1.5 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF2968 PF11180.8 ETO08474.1 - 0.53 9.9 11.8 0.53 9.9 4.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) COG6 PF06419.11 ETO08474.1 - 0.58 8.3 12.6 1.4 7.1 2.6 2.0 1 1 1 2 2 2 0 Conserved oligomeric complex COG6 LPP PF04728.13 ETO08474.1 - 0.59 10.6 4.2 11 6.5 0.5 2.6 2 1 0 2 2 2 0 Lipoprotein leucine-zipper DUF4200 PF13863.6 ETO08474.1 - 0.6 10.5 20.0 0.47 10.9 18.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Prominin PF05478.11 ETO08474.1 - 0.74 7.7 7.9 0.95 7.3 7.9 1.1 1 0 0 1 1 1 0 Prominin Tweety PF04906.13 ETO08474.1 - 0.75 8.4 3.5 1 8.0 3.5 1.1 1 0 0 1 1 1 0 Tweety RasGAP_C PF03836.15 ETO08474.1 - 0.83 9.8 14.3 3.7 7.7 11.8 2.2 1 1 1 2 2 2 0 RasGAP C-terminus Wtap PF17098.5 ETO08474.1 - 0.85 9.5 12.5 3.4 7.6 12.8 1.9 1 1 1 2 2 2 0 WTAP/Mum2p family YojJ PF10372.9 ETO08474.1 - 0.87 9.7 7.0 8.9 6.5 6.8 2.5 2 1 0 2 2 1 0 Bacterial membrane-spanning protein N-terminus DUF5094 PF17015.5 ETO08474.1 - 0.91 9.6 11.0 0.37 10.9 8.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5094) HIP1_clath_bdg PF16515.5 ETO08474.1 - 1 10.0 17.2 0.65 10.6 14.8 1.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4763 PF15960.5 ETO08474.1 - 1.1 8.6 13.3 0.11 11.7 3.7 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) CorA PF01544.18 ETO08474.1 - 1.1 8.5 3.8 3.7 6.8 3.9 1.7 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF641 PF04859.12 ETO08474.1 - 1.1 9.6 12.9 0.09 13.1 4.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) GBP_C PF02841.14 ETO08474.1 - 1.3 8.4 19.3 1.7 8.0 19.3 1.1 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Exonuc_VII_L PF02601.15 ETO08474.1 - 1.3 8.5 7.2 1.7 8.1 7.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lzipper-MIP1 PF14389.6 ETO08474.1 - 1.3 9.4 12.0 17 5.8 10.6 2.5 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Atg14 PF10186.9 ETO08474.1 - 1.4 8.0 14.8 2.3 7.2 14.2 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Med4 PF10018.9 ETO08474.1 - 1.4 8.6 12.8 0.93 9.1 3.3 2.1 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 BLOC1_2 PF10046.9 ETO08474.1 - 1.4 9.2 17.1 1.9 8.8 9.3 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 SLX9 PF15341.6 ETO08474.1 - 1.5 9.3 12.4 2.3 8.6 12.4 1.3 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 DUF2730 PF10805.8 ETO08474.1 - 1.5 9.0 8.3 1.2 9.3 6.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF2730) DUF812 PF05667.11 ETO08474.1 - 1.5 7.6 20.9 4.8 6.0 20.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF812) BRE1 PF08647.11 ETO08474.1 - 1.5 8.9 18.8 2.8 8.1 18.8 1.5 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Sec34 PF04136.15 ETO08474.1 - 1.6 8.6 7.8 8 6.3 7.8 2.0 1 1 0 1 1 1 0 Sec34-like family KLRAQ PF10205.9 ETO08474.1 - 1.6 9.0 14.9 3.1 8.1 14.9 1.6 1 1 0 1 1 1 0 Predicted coiled-coil domain-containing protein OmpH PF03938.14 ETO08474.1 - 1.9 8.8 20.2 4.3 7.7 20.2 1.6 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) Fib_alpha PF08702.10 ETO08474.1 - 1.9 8.7 13.7 2.7 8.1 4.6 2.2 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family HAUS-augmin3 PF14932.6 ETO08474.1 - 1.9 8.0 16.3 2.9 7.4 7.4 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 TolA_bind_tri PF16331.5 ETO08474.1 - 2.1 8.5 9.6 14 5.8 9.1 2.2 1 1 1 2 2 2 0 TolA binding protein trimerisation HAUS6_N PF14661.6 ETO08474.1 - 2.1 7.9 8.9 3.4 7.2 8.9 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus PRKG1_interact PF15898.5 ETO08474.1 - 2.2 9.2 16.2 2.9 8.8 15.7 1.4 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF4795 PF16043.5 ETO08474.1 - 2.5 7.6 21.8 15 5.1 21.8 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Cep57_CLD_2 PF14197.6 ETO08474.1 - 2.7 8.2 12.1 1.5e+02 2.5 12.1 2.8 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 Phage_GP20 PF06810.11 ETO08474.1 - 2.8 7.7 18.0 1.7 8.5 7.9 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 Muted PF14942.6 ETO08474.1 - 3.3 8.1 14.8 2.1 8.7 13.0 1.6 1 1 0 1 1 1 0 Organelle biogenesis, Muted-like protein Uso1_p115_C PF04871.13 ETO08474.1 - 3.4 8.1 20.8 1.4e+02 2.8 20.8 2.2 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region USP8_interact PF08941.10 ETO08474.1 - 3.5 7.4 10.5 7.8 6.3 6.4 2.0 1 1 1 2 2 2 0 USP8 interacting DUF730 PF05325.11 ETO08474.1 - 3.6 7.6 8.9 3.4 7.7 5.3 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF730) TPR_MLP1_2 PF07926.12 ETO08474.1 - 3.6 7.7 19.7 31 4.6 19.7 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein YabA PF06156.13 ETO08474.1 - 4.3 8.0 16.4 4.5 8.0 10.9 2.3 1 1 1 2 2 2 0 Initiation control protein YabA PEARLI-4 PF05278.12 ETO08474.1 - 4.8 6.7 14.5 2.3 7.7 12.0 1.6 1 1 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) THOC7 PF05615.13 ETO08474.1 - 5.3 7.3 13.5 14 5.9 13.5 1.8 1 1 0 1 1 1 0 Tho complex subunit 7 GTP-bdg_M PF16360.5 ETO08474.1 - 5.5 7.7 12.4 11 6.8 7.4 2.8 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region Occludin_ELL PF07303.13 ETO08474.1 - 5.7 7.7 9.8 24 5.7 8.7 2.1 1 1 1 2 2 2 0 Occludin homology domain DUF2203 PF09969.9 ETO08474.1 - 6 7.6 9.7 11 6.8 8.6 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) EMP24_GP25L PF01105.24 ETO08474.1 - 6.1 6.7 11.6 1 9.2 4.1 2.3 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD TMPIT PF07851.13 ETO08474.1 - 6.4 5.9 16.0 6.4 5.9 1.9 2.0 1 1 1 2 2 2 0 TMPIT-like protein zf-ACC PF17848.1 ETO08474.1 - 7 6.8 8.1 1.3 9.2 0.7 2.6 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain COG2 PF06148.11 ETO08474.1 - 7.5 6.7 13.6 3.9 7.6 4.9 2.2 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF4140 PF13600.6 ETO08474.1 - 7.9 7.0 11.4 3.3 8.2 1.1 3.2 1 1 2 3 3 2 0 N-terminal domain of unknown function (DUF4140) 5_nucleotid PF05761.14 ETO08474.1 - 8.1 5.2 8.5 10 4.8 8.5 1.1 1 0 0 1 1 1 0 5' nucleotidase family CENP-Q PF13094.6 ETO08474.1 - 8.9 6.5 15.9 19 5.4 15.9 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PCI PF01399.27 ETO08475.1 - 2.8e-12 47.1 0.1 9.1e-12 45.4 0.1 2.0 1 0 0 1 1 1 1 PCI domain TPR_1 PF00515.28 ETO08475.1 - 0.0064 16.3 0.8 0.017 14.9 0.4 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Paf67 PF10255.9 ETO08475.1 - 0.024 13.7 6.7 0.76 8.7 1.1 2.4 2 0 0 2 2 2 0 RNA polymerase I-associated factor PAF67 RasGEF PF00617.19 ETO08475.1 - 0.063 13.5 0.8 0.19 11.9 0.8 1.9 1 1 0 1 1 1 0 RasGEF domain TcdA_TcdB PF12919.7 ETO08476.1 - 0.26 10.6 0.0 0.33 10.2 0.0 1.1 1 0 0 1 1 1 0 TcdA/TcdB catalytic glycosyltransferase domain Connexin PF00029.19 ETO08478.1 - 0.01 15.6 0.9 0.013 15.2 0.3 1.5 1 1 1 2 2 2 0 Connexin DUF902 PF06001.13 ETO08478.1 - 0.11 13.0 0.1 5.4 7.6 0.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF902) OAD_gamma PF04277.13 ETO08478.1 - 1.1 10.0 4.5 0.98 10.1 1.2 2.3 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain XRN_M PF17846.1 ETO08479.1 - 7.5e-56 189.9 1.3 1.5e-55 188.9 1.3 1.4 1 0 0 1 1 1 1 Xrn1 helical domain XRN1_D1 PF18332.1 ETO08479.1 - 8.4e-25 87.6 0.1 2.6e-24 86.0 0.1 1.8 1 1 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain XRN1_D2_D3 PF18334.1 ETO08479.1 - 0.00043 20.4 1.0 0.00095 19.3 0.0 2.1 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain Mpp10 PF04006.12 ETO08480.1 - 0.002 16.7 22.3 0.0028 16.2 22.3 1.2 1 0 0 1 1 1 1 Mpp10 protein SAPS PF04499.15 ETO08480.1 - 0.018 13.8 6.9 0.024 13.5 6.9 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM76 PF16046.5 ETO08480.1 - 0.041 13.2 12.4 0.055 12.8 12.4 1.1 1 0 0 1 1 1 0 FAM76 protein BUD22 PF09073.10 ETO08480.1 - 0.058 12.7 24.6 0.078 12.3 24.6 1.1 1 0 0 1 1 1 0 BUD22 SID-1_RNA_chan PF13965.6 ETO08480.1 - 0.061 11.7 0.6 0.066 11.6 0.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2457 PF10446.9 ETO08480.1 - 0.15 11.2 23.9 0.2 10.8 23.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO08480.1 - 0.16 10.2 29.1 0.19 9.9 29.1 1.0 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.11 ETO08480.1 - 0.28 11.1 36.8 0.42 10.6 36.8 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) XRN_M PF17846.1 ETO08480.1 - 0.33 9.8 7.6 0.42 9.5 7.6 1.1 1 0 0 1 1 1 0 Xrn1 helical domain CDC45 PF02724.14 ETO08480.1 - 0.43 8.8 27.0 0.54 8.5 27.0 1.0 1 0 0 1 1 1 0 CDC45-like protein CNDH2_C PF16858.5 ETO08480.1 - 0.48 10.3 17.2 0.65 9.8 17.2 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DDHD PF02862.17 ETO08480.1 - 1.1 9.4 6.7 1.6 8.9 6.7 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO08480.1 - 2.6 6.7 12.3 3.3 6.4 12.3 1.2 1 0 0 1 1 1 0 Presenilin Paf1 PF03985.13 ETO08480.1 - 3.4 6.6 24.2 4.5 6.2 24.2 1.2 1 0 0 1 1 1 0 Paf1 CLN3 PF02487.17 ETO08480.1 - 4 6.4 6.4 13 4.7 6.4 1.8 1 1 0 1 1 1 0 CLN3 protein Rhabdo_ncap PF00945.18 ETO08480.1 - 5.5 5.8 9.0 6.8 5.5 9.0 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein DUF913 PF06025.12 ETO08480.1 - 8.7 5.2 11.2 11 4.8 11.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RSN1_7TM PF02714.15 ETO08481.1 - 4.7e-26 91.7 37.6 5.1e-21 75.2 23.0 3.5 1 1 2 3 3 3 2 Calcium-dependent channel, 7TM region, putative phosphate PHM7_cyt PF14703.6 ETO08481.1 - 4.4e-06 27.1 0.0 7.8e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter IBN_N PF03810.19 ETO08482.1 - 0.00071 19.4 0.0 0.0016 18.3 0.0 1.5 1 0 0 1 1 1 1 Importin-beta N-terminal domain Pox_P35 PF03213.14 ETO08483.1 - 0.035 13.3 6.1 0.049 12.9 4.3 1.9 2 0 0 2 2 2 0 Poxvirus P35 protein PAT1 PF09770.9 ETO08484.1 - 0.14 10.4 16.4 0.17 10.1 16.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 GD_AH_C PF04295.13 ETO08484.1 - 0.31 9.8 1.0 5.2 5.8 0.8 2.0 2 0 0 2 2 2 0 D-galactarate dehydratase / Altronate hydrolase, C terminus Roughex PF06020.11 ETO08484.1 - 0.6 9.1 9.0 0.86 8.6 9.0 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF3021 PF11457.8 ETO08485.1 - 0.02 15.2 4.3 0.02 15.2 4.3 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3021) DUF4131 PF13567.6 ETO08485.1 - 4.1 7.0 10.7 3 7.5 0.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) HEAT PF02985.22 ETO08486.1 - 0.004 17.3 0.1 0.27 11.6 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat Spot_14 PF07084.12 ETO08486.1 - 0.02 15.1 1.1 0.02 15.1 1.1 2.3 3 0 0 3 3 3 0 Thyroid hormone-inducible hepatic protein Spot 14 Neur_chan_memb PF02932.16 ETO08486.1 - 0.071 13.2 0.9 1.6 8.7 0.2 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Vfa1 PF08432.10 ETO08486.1 - 0.46 10.8 15.1 2.6 8.3 2.6 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO08486.1 - 0.75 9.5 7.5 0.079 12.7 0.8 2.1 2 0 0 2 2 2 0 Connexin Zip PF02535.22 ETO08486.1 - 0.87 8.7 3.5 2.6 7.2 1.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter CAC1F_C PF16885.5 ETO08486.1 - 1.9 8.1 9.2 4.7 6.8 3.6 2.1 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term CPSF100_C PF13299.6 ETO08486.1 - 2.3 8.4 7.6 0.25 11.5 1.4 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal HEPN_AbiV PF18728.1 ETO08486.1 - 3.2 7.9 9.3 9.2 6.4 2.7 2.3 2 0 0 2 2 2 0 AbiV SMN PF06003.12 ETO08486.1 - 5.8 6.1 7.4 1.1 8.5 1.5 2.0 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) ASFV_p27 PF06556.11 ETO08487.1 - 0.0043 17.2 0.2 0.012 15.7 0.2 1.7 1 0 0 1 1 1 1 IAP-like protein p27 C-terminus 2C_adapt PF08793.10 ETO08487.1 - 0.055 13.7 0.0 0.17 12.1 0.0 1.8 1 0 0 1 1 1 0 2-cysteine adaptor domain Cytochrom_B_C PF00032.17 ETO08488.1 - 0.00035 20.8 2.1 0.0017 18.6 2.2 2.1 1 1 1 2 2 2 1 Cytochrome b(C-terminal)/b6/petD NiFe_hyd_3_EhaA PF17367.2 ETO08488.1 - 0.12 12.5 2.1 0.14 12.3 0.4 1.9 2 0 0 2 2 2 0 NiFe-hydrogenase-type-3 Eha complex subunit A ATP-synt_8 PF00895.20 ETO08488.1 - 8.4 6.9 7.6 3.1 8.3 0.5 3.3 4 0 0 4 4 4 0 ATP synthase protein 8 Peptidase_S28 PF05577.12 ETO08490.1 - 2.2e-18 66.3 0.2 2.7e-18 66.0 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Tctex-1 PF03645.13 ETO08491.1 - 4.3e-25 87.9 0.5 5.1e-25 87.7 0.5 1.1 1 0 0 1 1 1 1 Tctex-1 family Ni_hydr_CYTB PF01292.20 ETO08494.1 - 0.0073 15.9 0.6 0.014 15.0 0.5 1.6 1 1 1 2 2 2 1 Prokaryotic cytochrome b561 PTPS_related PF10131.9 ETO08494.1 - 0.01 14.2 0.3 0.013 13.9 0.3 1.1 1 0 0 1 1 1 0 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein DUF2157 PF09925.9 ETO08494.1 - 0.29 10.9 2.6 2.4 7.9 2.6 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) YfhO PF09586.10 ETO08494.1 - 0.99 7.6 3.3 1.3 7.2 3.3 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO Ytca PF17090.5 ETO08494.1 - 2.1 8.9 10.0 2.6 8.6 5.0 2.3 1 1 1 2 2 2 0 Uncharacterised protein family Tudor-knot PF11717.8 ETO08495.1 - 0.014 15.3 5.8 0.077 12.9 3.6 2.7 2 1 0 2 2 2 0 RNA binding activity-knot of a chromodomain DUF1325 PF07039.11 ETO08495.1 - 0.02 15.0 0.4 0.041 14.0 0.4 1.5 1 1 0 1 1 1 0 SGF29 tudor-like domain MBT PF02820.18 ETO08495.1 - 0.078 13.3 1.5 2.6 8.5 0.3 2.4 2 0 0 2 2 2 0 mbt repeat Chlam_PMP PF02415.17 ETO08496.1 - 0.00032 21.0 20.6 0.034 14.6 0.4 6.0 7 0 0 7 7 7 3 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SET PF00856.28 ETO08498.1 - 0.0087 16.5 0.0 0.012 16.0 0.0 1.3 1 0 0 1 1 1 1 SET domain Kelch_6 PF13964.6 ETO08499.1 - 0.00012 22.2 4.8 0.00045 20.4 0.4 3.5 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO08499.1 - 0.00026 20.5 1.2 0.0017 17.9 0.2 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO08499.1 - 0.004 17.1 1.6 0.21 11.6 0.1 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO08499.1 - 0.017 15.1 4.4 0.099 12.7 0.3 3.4 4 0 0 4 4 4 0 Kelch motif YpsA PF06908.11 ETO08499.1 - 0.064 13.2 0.1 0.53 10.3 0.1 2.1 2 0 0 2 2 2 0 YspA SLOG family Kelch_4 PF13418.6 ETO08499.1 - 0.29 11.2 2.6 0.39 10.8 0.1 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain FH2 PF02181.23 ETO08500.1 - 3.6e-05 23.0 5.0 3.6e-05 23.0 5.0 3.1 1 1 2 3 3 3 3 Formin Homology 2 Domain Peptidase_S64 PF08192.11 ETO08500.1 - 3.4 6.1 21.3 0.18 10.2 1.6 2.0 2 0 0 2 2 2 0 Peptidase family S64 ATF7IP_BD PF16788.5 ETO08500.1 - 4.9 7.2 23.7 1.9 8.5 2.1 2.7 1 1 2 3 3 3 0 ATF-interacting protein binding domain SpecificRecomb PF10136.9 ETO08500.1 - 7.4 4.7 10.3 0.37 9.0 2.4 1.9 1 1 0 2 2 2 0 Site-specific recombinase WD40 PF00400.32 ETO08501.1 - 1.7e-77 253.4 27.6 4.8e-10 39.9 0.1 10.6 10 0 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08501.1 - 1.3e-11 44.7 7.5 0.2 12.0 0.0 7.3 1 1 5 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO08501.1 - 3.2e-11 43.4 0.0 7.9e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 ETO08501.1 - 3.9e-09 35.9 10.1 0.039 12.9 0.1 7.4 3 2 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO08501.1 - 5.6e-09 35.2 18.3 0.65 8.6 0.2 8.0 3 2 4 8 8 8 6 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO08501.1 - 1.5e-07 30.9 3.2 3.4e-07 29.8 3.2 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO08501.1 - 9.7e-05 22.5 1.3 0.0002 21.4 0.5 2.0 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Str_synth PF03088.16 ETO08501.1 - 0.00015 21.8 0.3 0.66 10.1 0.0 4.9 4 2 1 5 5 5 1 Strictosidine synthase AAA_22 PF13401.6 ETO08501.1 - 0.00041 20.6 0.0 0.0014 18.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain PD40 PF07676.12 ETO08501.1 - 0.0011 18.8 2.8 18 5.4 0.0 4.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO08501.1 - 0.0014 18.7 1.1 0.0045 17.1 1.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) RNA_helicase PF00910.22 ETO08501.1 - 0.0023 18.3 3.0 0.24 11.8 0.0 3.4 2 1 1 3 3 3 1 RNA helicase AAA PF00004.29 ETO08501.1 - 0.0084 16.5 0.0 0.5 10.8 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO08501.1 - 0.0088 16.6 1.4 0.053 14.1 0.1 2.9 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO08501.1 - 0.032 14.6 0.2 0.16 12.4 0.0 2.2 2 1 1 3 3 3 0 AAA ATPase domain BSD PF03909.17 ETO08501.1 - 0.035 14.1 0.2 4 7.5 0.1 2.9 2 0 0 2 2 2 0 BSD domain TsaE PF02367.17 ETO08501.1 - 0.055 13.5 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETO08501.1 - 0.057 13.9 0.4 0.25 11.8 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_5 PF07728.14 ETO08501.1 - 0.063 13.3 0.0 0.26 11.3 0.0 2.1 2 0 0 2 2 1 0 AAA domain (dynein-related subfamily) AAA_30 PF13604.6 ETO08501.1 - 0.077 12.7 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETO08501.1 - 0.099 12.5 0.0 0.29 11.0 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase AAA_33 PF13671.6 ETO08501.1 - 0.1 12.8 0.0 0.31 11.2 0.0 1.9 1 0 0 1 1 1 0 AAA domain HSP70 PF00012.20 ETO08503.1 - 2.1e-08 32.8 2.9 2.1e-08 32.8 2.9 2.5 2 1 1 3 3 3 1 Hsp70 protein DUF3837 PF12939.7 ETO08503.1 - 1 9.8 5.1 2 8.9 0.4 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3837) NAM-associated PF14303.6 ETO08503.1 - 6 7.6 38.1 2.4 8.9 16.8 2.6 2 1 0 2 2 2 0 No apical meristem-associated C-terminal domain HSP70 PF00012.20 ETO08504.1 - 7.1e-95 318.4 2.9 3.5e-66 223.6 0.5 4.0 2 1 0 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 ETO08504.1 - 0.0002 20.3 0.0 0.00036 19.5 0.0 1.4 1 0 0 1 1 1 1 MreB/Mbl protein Spo12 PF05032.12 ETO08504.1 - 0.041 13.8 0.1 0.25 11.3 0.1 2.4 1 0 0 1 1 1 0 Spo12 family WD40 PF00400.32 ETO08506.1 - 9.5e-40 133.9 20.9 8.7e-07 29.5 0.3 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08506.1 - 1.1e-11 44.8 4.0 0.087 13.1 0.0 5.4 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08506.1 - 3.1e-10 39.3 7.0 0.091 11.4 0.1 5.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Kri1_C PF12936.7 ETO08507.1 - 5.6 7.2 11.8 41 4.4 8.4 3.4 1 1 1 2 2 2 0 KRI1-like family C-terminal WD40 PF00400.32 ETO08508.1 - 8.3e-55 181.5 11.7 1.7e-10 41.3 0.1 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08508.1 - 5.1e-18 65.2 0.9 0.0012 19.1 0.0 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08508.1 - 8e-09 34.9 0.1 0.39 9.6 0.0 4.9 2 2 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO08508.1 - 2.9e-07 30.1 0.4 0.037 13.4 0.1 3.4 2 2 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO08508.1 - 3.2e-05 22.8 5.1 0.57 8.8 0.0 4.4 2 1 3 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO08508.1 - 0.00028 20.7 2.9 4.4 7.4 0.3 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO08508.1 - 0.0014 17.3 0.1 0.41 9.1 0.0 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO08508.1 - 0.025 13.9 1.1 27 4.0 0.0 3.9 2 2 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal DUF5122 PF17164.4 ETO08508.1 - 0.088 13.1 0.2 3.9 7.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller ASH PF15780.5 ETO08509.1 - 4.2e-05 23.7 0.0 6.9e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TAA-Trp-ring PF15401.6 ETO08509.1 - 0.073 13.5 0.6 0.14 12.6 0.6 1.4 1 0 0 1 1 1 0 Tryptophan-ring motif of head of Trimeric autotransporter adhesin CDC45 PF02724.14 ETO08510.1 - 0.0036 15.7 4.9 0.0032 15.8 4.9 1.1 1 0 0 1 1 1 1 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO08510.1 - 0.022 15.2 2.1 0.023 15.1 2.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Roughex PF06020.11 ETO08510.1 - 0.44 9.6 5.8 0.56 9.2 5.8 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Sporozoite_P67 PF05642.11 ETO08510.1 - 0.77 7.8 7.6 0.92 7.5 7.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 ETO08510.1 - 2.4 6.9 6.8 2.7 6.7 6.8 1.1 1 0 0 1 1 1 0 Presenilin Apc15p PF05841.11 ETO08510.1 - 5.2 7.9 12.6 9.8 7.0 12.6 1.4 1 0 0 1 1 1 0 Apc15p protein Kelch_4 PF13418.6 ETO08511.1 - 0.0071 16.3 0.1 0.023 14.7 0.1 1.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Orf78 PF06024.12 ETO08511.1 - 0.11 12.8 0.5 0.2 12.0 0.5 1.4 1 0 0 1 1 1 0 Orf78 (ac78) WD40 PF00400.32 ETO08512.1 - 8.2e-40 134.1 13.9 6e-08 33.2 0.1 6.2 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08512.1 - 2.1e-20 72.8 1.8 0.00011 22.4 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08512.1 - 1.3e-11 44.1 1.0 0.0014 17.7 0.0 4.5 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO08512.1 - 8.3e-10 38.5 4.1 0.0066 15.8 0.0 3.8 2 2 1 3 3 3 3 WD40-like domain Nbas_N PF15492.6 ETO08512.1 - 0.0043 16.4 0.4 0.98 8.7 0.0 2.8 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO08512.1 - 0.033 12.8 3.3 1.6 7.3 0.1 3.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 PD40 PF07676.12 ETO08512.1 - 0.13 12.2 0.1 13 5.8 0.0 3.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO08513.1 - 6.2e-20 71.2 6.5 1.6e-08 35.1 0.1 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08513.1 - 2e-09 37.6 1.3 0.0078 16.5 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08513.1 - 6.1e-07 29.1 0.4 0.00041 19.8 0.1 2.2 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO08513.1 - 0.0012 17.6 0.1 0.33 9.5 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO08513.1 - 0.0027 16.7 0.1 0.034 13.1 0.1 2.3 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 ETO08513.1 - 0.038 12.7 0.2 0.19 10.4 0.1 2.0 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PH PF00169.29 ETO08514.1 - 1.7e-11 44.6 11.0 5.5e-05 23.6 1.0 4.4 3 2 0 3 3 3 2 PH domain PH_11 PF15413.6 ETO08514.1 - 4e-07 30.4 13.0 0.00013 22.3 2.3 3.2 3 1 0 3 3 3 2 Pleckstrin homology domain PH_2 PF08458.10 ETO08514.1 - 0.00023 21.5 0.3 0.042 14.2 0.1 2.5 2 0 0 2 2 2 1 Plant pleckstrin homology-like region SR-25 PF10500.9 ETO08514.1 - 0.0028 17.3 6.7 0.0028 17.3 6.7 2.3 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Mcp5_PH PF12814.7 ETO08514.1 - 0.058 13.5 0.4 11 6.2 0.0 3.0 3 0 0 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology MID_MedPIWI PF18296.1 ETO08514.1 - 0.52 10.1 22.7 1.1 9.0 4.7 2.9 3 0 0 3 3 3 0 MID domain of medPIWI Tim54 PF11711.8 ETO08514.1 - 2.5 6.8 13.5 1.9 7.2 0.3 2.4 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 ZYG-11_interact PF05884.12 ETO08515.1 - 0.16 11.3 0.1 0.2 11.1 0.1 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 Exonuc_VII_L PF02601.15 ETO08518.1 - 0.041 13.5 10.2 0.05 13.2 10.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF883 PF05957.13 ETO08518.1 - 0.12 12.9 6.5 0.35 11.5 1.2 2.6 2 1 1 3 3 2 0 Bacterial protein of unknown function (DUF883) HalX PF08663.10 ETO08518.1 - 0.13 12.5 1.1 4.9 7.5 0.1 2.3 2 0 0 2 2 2 0 HalX domain Spike_torovirin PF17072.5 ETO08518.1 - 0.15 9.2 2.6 0.18 8.9 2.6 1.0 1 0 0 1 1 1 0 Torovirinae spike glycoprotein MCPsignal PF00015.21 ETO08518.1 - 0.19 11.6 6.9 0.29 10.9 6.9 1.3 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Baculo_PEP_C PF04513.12 ETO08518.1 - 0.19 11.8 15.6 1.8 8.6 15.5 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YtxH PF12732.7 ETO08518.1 - 0.23 12.0 10.5 1.2e+02 3.3 10.5 2.9 1 1 0 1 1 1 0 YtxH-like protein Golgin_A5 PF09787.9 ETO08518.1 - 0.24 10.8 24.7 0.13 11.7 21.8 1.8 1 1 1 2 2 2 0 Golgin subfamily A member 5 DUF3450 PF11932.8 ETO08518.1 - 0.29 10.4 16.0 0.38 10.0 16.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 ETO08518.1 - 0.3 11.3 24.9 3 8.0 21.9 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family V_ATPase_I PF01496.19 ETO08518.1 - 0.31 8.9 12.1 0.36 8.7 12.1 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Flagellar_rod PF05149.12 ETO08518.1 - 0.33 10.4 17.6 0.53 9.7 17.6 1.3 1 0 0 1 1 1 0 Paraflagellar rod protein SlyX PF04102.12 ETO08518.1 - 0.45 11.2 17.9 3.3 8.4 6.0 2.8 1 1 1 2 2 2 0 SlyX DUF4407 PF14362.6 ETO08518.1 - 0.52 9.6 10.9 0.77 9.0 10.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 ETO08518.1 - 0.65 10.2 18.5 1 9.6 15.8 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Hemagglutinin PF00509.18 ETO08518.1 - 0.73 8.2 14.6 1.3 7.3 14.1 1.6 1 1 1 2 2 2 0 Haemagglutinin LPP PF04728.13 ETO08518.1 - 0.84 10.1 17.8 2.9 8.3 2.6 3.8 1 1 2 3 3 3 0 Lipoprotein leucine-zipper DLP_helical PF18709.1 ETO08518.1 - 0.94 8.6 17.9 2 7.5 15.9 2.1 1 1 1 2 2 2 0 Dynamin-like helical domain Cob_adeno_trans PF01923.18 ETO08518.1 - 0.95 9.6 6.5 0.34 11.0 3.3 1.8 1 1 1 2 2 2 0 Cobalamin adenosyltransferase FAM76 PF16046.5 ETO08518.1 - 1.1 8.6 24.5 3.9 6.7 24.5 1.8 1 1 0 1 1 1 0 FAM76 protein DUF641 PF04859.12 ETO08518.1 - 1.5 9.2 15.5 1.2 9.5 3.5 2.9 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) ApoO PF09769.9 ETO08518.1 - 1.5 8.8 4.3 31 4.5 3.9 2.7 1 1 1 2 2 2 0 Apolipoprotein O Tropomyosin_1 PF12718.7 ETO08518.1 - 1.5 9.0 26.8 0.062 13.4 14.4 2.9 2 1 1 3 3 3 0 Tropomyosin like Mt_ATP-synt_D PF05873.12 ETO08518.1 - 1.5 8.6 21.1 1.6 8.5 0.4 3.1 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) ALMT PF11744.8 ETO08518.1 - 1.5 7.5 12.9 1.8 7.3 12.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Spc7 PF08317.11 ETO08518.1 - 1.6 7.6 23.4 0.74 8.6 20.9 1.7 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 ETO08518.1 - 1.7 9.0 14.1 7.8 6.8 9.2 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ETO08518.1 - 1.8 8.6 20.2 19 5.3 17.4 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TolA_bind_tri PF16331.5 ETO08518.1 - 2.7 8.1 22.2 7.5 6.7 8.8 2.5 1 1 1 2 2 2 0 TolA binding protein trimerisation UPF0242 PF06785.11 ETO08518.1 - 5.1 7.2 28.6 3.2 7.8 18.1 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus USP8_interact PF08941.10 ETO08518.1 - 6.3 6.6 18.1 4.6 7.0 8.5 2.3 1 1 0 2 2 2 0 USP8 interacting RNA_pol_Rpb4 PF03874.16 ETO08519.1 - 0.083 13.2 6.5 0.18 12.1 6.5 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb4 Methyltransf_12 PF08242.12 ETO08519.1 - 1.2 9.9 3.8 2.6 8.8 3.8 1.6 1 0 0 1 1 1 0 Methyltransferase domain ubiquitin PF00240.23 ETO08520.1 - 1.2e-11 44.1 9.1 3.8e-09 36.2 4.7 2.8 2 1 0 2 2 2 1 Ubiquitin family Ubiquitin_2 PF14560.6 ETO08520.1 - 8.3e-05 23.0 1.5 0.00022 21.6 1.5 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD PF11976.8 ETO08520.1 - 0.0024 17.7 12.8 0.035 13.9 7.1 3.1 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like UN_NPL4 PF11543.8 ETO08520.1 - 0.0096 16.4 4.2 0.67 10.5 4.2 2.8 1 1 0 1 1 1 1 Nuclear pore localisation protein NPL4 YukD PF08817.10 ETO08520.1 - 0.062 14.0 0.1 0.16 12.7 0.1 1.7 1 1 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD DUF3474 PF11960.8 ETO08520.1 - 0.14 12.3 1.9 0.18 12.0 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) Glyco_transf_41 PF13844.6 ETO08520.1 - 0.14 10.5 5.7 0.067 11.6 3.2 1.6 2 0 0 2 2 2 0 Glycosyl transferase family 41 Ubiquitin_4 PF18036.1 ETO08520.1 - 0.23 11.6 8.8 0.66 10.1 5.5 2.7 2 1 0 2 2 2 0 Ubiquitin-like domain zf-RanBP PF00641.18 ETO08521.1 - 0.00011 21.5 2.6 0.00011 21.5 2.6 2.8 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others Ras PF00071.22 ETO08522.1 - 1.4e-14 54.0 0.0 2.4e-14 53.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Sec63 PF02889.16 ETO08523.1 - 1e-60 205.1 0.1 1.5e-60 204.6 0.1 1.2 1 0 0 1 1 1 1 Sec63 Brl domain Helicase_C PF00271.31 ETO08523.1 - 0.00066 20.0 0.0 0.0021 18.4 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HHH_5 PF14520.6 ETO08523.1 - 0.16 12.6 0.0 0.7 10.5 0.0 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix domain DUF898 PF05987.13 ETO08524.1 - 0.0011 18.1 0.6 0.002 17.3 0.6 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) Vfa1 PF08432.10 ETO08525.1 - 0.14 12.5 22.1 0.025 14.9 8.3 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CPSF100_C PF13299.6 ETO08525.1 - 8.1 6.6 13.8 32 4.7 0.1 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 ETO08525.1 - 9.1 6.3 12.6 14 5.7 12.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Radial_spoke PF04712.12 ETO08527.1 - 5.2e-64 217.0 11.0 3.2e-31 108.8 0.4 4.1 2 2 1 3 3 3 3 Radial spokehead-like protein YgaB PF14182.6 ETO08528.1 - 0.061 13.7 0.7 0.19 12.1 0.6 1.9 1 1 1 2 2 2 0 YgaB-like protein Popeye PF04831.13 ETO08529.1 - 1e-07 32.2 0.5 1.3e-07 31.9 0.5 1.3 1 0 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 ETO08529.1 - 5.6e-07 29.5 0.0 3e-06 27.2 0.0 2.0 1 1 1 2 2 2 1 Cyclic nucleotide-binding domain RIO1 PF01163.22 ETO08530.1 - 0.029 14.0 0.0 0.17 11.5 0.1 2.0 2 0 0 2 2 2 0 RIO1 family DUF1858 PF08984.11 ETO08530.1 - 0.1 12.8 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1858) APH PF01636.23 ETO08530.1 - 0.17 11.8 0.0 0.65 9.9 0.1 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family TPR_MLP1_2 PF07926.12 ETO08531.1 - 7.3e-05 22.8 0.6 7.3e-05 22.8 0.6 2.5 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein ADIP PF11559.8 ETO08531.1 - 0.00089 19.4 8.6 0.0031 17.6 1.4 2.8 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding HOOK PF05622.12 ETO08531.1 - 0.0024 16.1 6.9 0.003 15.8 6.9 1.2 1 0 0 1 1 1 1 HOOK protein CENP-F_leu_zip PF10473.9 ETO08531.1 - 0.0028 17.7 6.4 0.0028 17.7 6.4 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO08531.1 - 0.0085 15.0 8.3 0.017 14.1 8.4 1.4 1 1 0 1 1 1 1 Spc7 kinetochore protein TMF_DNA_bd PF12329.8 ETO08531.1 - 0.013 15.4 5.4 0.75 9.8 0.1 3.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding EzrA PF06160.12 ETO08531.1 - 0.017 13.4 6.1 0.022 12.9 6.1 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA ERM PF00769.19 ETO08531.1 - 0.018 14.9 3.2 0.02 14.7 3.2 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family MPS2 PF17060.5 ETO08531.1 - 0.028 13.7 3.4 0.044 13.1 3.3 1.4 1 1 0 1 1 1 0 Monopolar spindle protein 2 IFT57 PF10498.9 ETO08531.1 - 0.028 13.4 7.2 0.022 13.7 5.9 1.5 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 DHR10 PF18595.1 ETO08531.1 - 0.029 14.4 5.0 0.14 12.2 1.8 2.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain LRR_3 PF07725.12 ETO08531.1 - 0.068 13.0 0.6 0.2 11.6 0.6 1.9 1 0 0 1 1 1 0 Leucine Rich Repeat GAS PF13851.6 ETO08531.1 - 0.15 11.4 8.3 0.16 11.3 7.5 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CdvA PF18822.1 ETO08531.1 - 0.15 11.9 3.6 0.35 10.7 0.3 2.5 2 0 0 2 2 2 0 CdvA-like coiled-coil domain Stap_Strp_toxin PF01123.20 ETO08531.1 - 0.22 12.4 3.0 0.87 10.5 0.4 2.7 1 1 2 3 3 2 0 Staphylococcal/Streptococcal toxin, OB-fold domain UPF0242 PF06785.11 ETO08531.1 - 0.27 11.3 7.4 1.9 8.5 0.6 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF724 PF05266.14 ETO08531.1 - 0.28 11.0 8.0 0.37 10.6 6.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 ETO08531.1 - 0.32 11.4 4.4 11 6.5 0.5 3.3 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DASH_Hsk3 PF08227.11 ETO08531.1 - 0.32 11.4 2.6 57 4.2 0.0 3.5 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like FapA PF03961.13 ETO08531.1 - 0.54 8.8 3.6 0.79 8.3 3.6 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin_2 PF01920.20 ETO08531.1 - 0.76 9.8 12.2 1.7 8.7 1.7 3.4 1 1 2 3 3 3 0 Prefoldin subunit Fib_alpha PF08702.10 ETO08531.1 - 0.79 9.9 14.6 1.7 8.8 6.5 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family KxDL PF10241.9 ETO08531.1 - 0.9 9.9 6.6 11 6.4 1.1 2.6 1 1 0 2 2 2 0 Uncharacterized conserved protein YlqD PF11068.8 ETO08531.1 - 1 9.8 10.2 2.8 8.3 3.2 2.4 1 1 1 2 2 2 0 YlqD protein Csm1_N PF18504.1 ETO08531.1 - 1.8 8.9 6.0 15 6.0 0.1 3.0 1 1 3 4 4 4 0 Csm1 N-terminal domain DUF641 PF04859.12 ETO08531.1 - 2 8.8 8.2 2.1 8.7 1.8 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Tup_N PF08581.10 ETO08531.1 - 2.4 8.5 7.2 4 7.8 2.5 2.9 1 1 2 3 3 3 0 Tup N-terminal SHR-BD PF06650.12 ETO08532.1 - 1.4e-07 31.2 1.4 0.018 14.4 0.1 3.4 3 1 0 3 3 3 2 SHR-binding domain of vacuolar-sorting associated protein 13 SR-25 PF10500.9 ETO08532.1 - 5.3 6.6 9.5 8.9 5.9 9.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ETO08533.1 - 1.1e-12 47.9 0.0 1.1e-12 47.9 0.0 2.0 3 0 0 3 3 3 1 Protein kinase domain VPS13_C PF16909.5 ETO08534.1 - 0.00016 21.5 0.0 0.0012 18.6 0.0 2.4 2 2 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal VPS13_C PF16909.5 ETO08535.1 - 1.6e-10 41.1 4.6 8.7e-06 25.6 0.2 2.4 2 0 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 ETO08535.1 - 2.3e-09 37.5 0.1 1.1e-08 35.3 0.0 1.9 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain FAP206 PF12018.8 ETO08535.1 - 0.066 12.7 0.2 0.12 11.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function Laminin_G_3 PF13385.6 ETO08536.1 - 2e-06 28.0 0.0 6.9e-06 26.3 0.0 1.9 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DHHC PF01529.20 ETO08537.1 - 2.6e-26 92.3 14.8 2.6e-26 92.3 14.8 2.8 3 1 0 3 3 2 1 DHHC palmitoyltransferase Cwf_Cwc_15 PF04889.12 ETO08537.1 - 0.0001 22.1 7.5 0.00014 21.7 7.5 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein BSP_II PF05432.11 ETO08537.1 - 0.0013 18.5 4.0 0.0019 17.9 4.0 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) MFAP1 PF06991.11 ETO08537.1 - 0.0073 16.2 5.1 0.011 15.7 5.1 1.1 1 0 0 1 1 1 1 Microfibril-associated/Pre-mRNA processing PBP1_TM PF14812.6 ETO08537.1 - 0.06 13.7 9.2 0.19 12.1 9.2 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MMM1 PF10296.9 ETO08537.1 - 0.077 12.0 0.7 0.11 11.5 0.7 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Afi1 PF07792.12 ETO08537.1 - 0.31 11.5 6.4 0.48 10.9 6.4 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NPR3 PF03666.13 ETO08537.1 - 0.42 9.3 3.0 0.52 9.0 3.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3245 PF11595.8 ETO08537.1 - 0.43 11.0 10.5 0.63 10.5 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) TRAP_alpha PF03896.16 ETO08537.1 - 0.57 9.3 4.2 0.84 8.8 4.2 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Pes-10 PF07149.11 ETO08537.1 - 0.63 9.0 6.1 0.86 8.6 6.1 1.1 1 0 0 1 1 1 0 Pes-10 RXT2_N PF08595.11 ETO08537.1 - 0.89 9.6 9.4 1.9 8.5 8.9 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF2722 PF10846.8 ETO08537.1 - 1.1 8.1 11.1 1.5 7.6 11.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) FAM176 PF14851.6 ETO08537.1 - 1.2 8.8 5.3 2.1 8.0 5.3 1.4 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 ETO08537.1 - 1.4 8.7 13.1 2 8.1 13.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 ETO08537.1 - 6.8 7.2 14.3 12 6.3 14.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 ETO08539.1 - 0.01 15.9 7.1 0.021 14.9 3.7 2.4 2 0 0 2 2 2 0 RXT2-like, N-terminal PPP4R2 PF09184.11 ETO08539.1 - 0.016 14.9 10.0 0.022 14.3 10.0 1.4 1 1 0 1 1 1 0 PPP4R2 Utp14 PF04615.13 ETO08539.1 - 0.45 9.0 17.0 0.39 9.2 14.4 1.8 2 0 0 2 2 2 0 Utp14 protein Sigma70_ner PF04546.13 ETO08539.1 - 0.5 10.2 13.1 0.13 12.1 9.4 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region Cwf_Cwc_15 PF04889.12 ETO08539.1 - 0.51 10.0 22.0 0.49 10.1 17.9 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CobT PF06213.12 ETO08539.1 - 0.73 9.2 17.2 0.079 12.3 8.1 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT TFB6 PF17110.5 ETO08539.1 - 1.5 8.6 11.3 7.3 6.3 6.9 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF4484 PF14831.6 ETO08539.1 - 1.7 8.6 13.7 8.7 6.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) BUD22 PF09073.10 ETO08539.1 - 2.4 7.4 18.9 3.9 6.7 18.9 1.3 1 1 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO08539.1 - 3.3 5.8 19.3 0.52 8.5 15.0 1.6 2 0 0 2 2 2 0 Nop14-like family CPSF100_C PF13299.6 ETO08539.1 - 4.3 7.5 7.1 17 5.5 4.3 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal TRAP_alpha PF03896.16 ETO08539.1 - 6 6.0 8.7 4.4 6.4 5.7 1.9 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 ETO08539.1 - 7.3 4.7 23.3 1.9 6.7 18.6 1.9 2 0 0 2 2 2 0 CDC45-like protein TIP49 PF06068.13 ETO08540.1 - 3.8e-111 371.7 11.1 7.9e-59 199.6 0.1 2.4 1 1 1 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 ETO08540.1 - 3.4e-21 75.2 0.8 5.8e-21 74.4 0.1 1.8 2 0 0 2 2 1 1 TIP49 AAA-lid domain AAA PF00004.29 ETO08540.1 - 1e-09 38.9 1.3 8.6e-07 29.4 0.3 2.7 1 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO08540.1 - 7.6e-07 29.5 0.3 0.0034 17.6 0.3 2.7 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETO08540.1 - 1.2e-06 28.4 0.8 0.001 18.8 0.3 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO08540.1 - 7.1e-06 26.1 1.5 0.00093 19.2 0.2 2.8 2 1 1 3 3 3 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO08540.1 - 1.2e-05 25.7 0.1 4.3e-05 24.0 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain DnaB_C PF03796.15 ETO08540.1 - 4.3e-05 23.0 0.1 0.0001 21.7 0.1 1.6 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain AAA_19 PF13245.6 ETO08540.1 - 4.3e-05 23.9 4.7 0.0016 18.8 4.7 2.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO08540.1 - 0.00052 20.6 0.4 0.002 18.6 0.0 2.2 3 0 0 3 3 2 1 AAA domain AAA_25 PF13481.6 ETO08540.1 - 0.00076 19.1 0.6 0.002 17.7 0.6 1.9 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETO08540.1 - 0.00085 18.8 0.7 0.018 14.4 0.3 2.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO08540.1 - 0.00098 18.9 0.5 0.23 11.2 0.1 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain NACHT PF05729.12 ETO08540.1 - 0.002 18.1 0.0 0.0036 17.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 ETO08540.1 - 0.0035 16.9 0.0 0.032 13.7 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region ATPase PF06745.13 ETO08540.1 - 0.004 16.5 0.1 0.0095 15.3 0.1 1.7 1 0 0 1 1 1 1 KaiC ResIII PF04851.15 ETO08540.1 - 0.0064 16.5 0.7 0.06 13.3 0.7 2.4 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit APS_kinase PF01583.20 ETO08540.1 - 0.01 15.7 0.0 0.13 12.1 0.0 2.2 2 0 0 2 2 2 0 Adenylylsulphate kinase AAA_30 PF13604.6 ETO08540.1 - 0.011 15.5 0.1 0.14 11.9 0.1 2.3 2 0 0 2 2 2 0 AAA domain DUF2075 PF09848.9 ETO08540.1 - 0.012 14.9 0.2 0.022 14.0 0.1 1.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) ABC_tran PF00005.27 ETO08540.1 - 0.017 15.6 0.3 0.039 14.5 0.3 1.7 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ETO08540.1 - 0.022 15.1 0.1 0.12 12.7 0.0 2.3 1 1 1 2 2 2 0 RNA helicase Parvo_NS1 PF01057.17 ETO08540.1 - 0.024 13.7 0.0 0.04 13.0 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 ETO08540.1 - 0.024 14.6 0.1 0.069 13.2 0.1 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ETO08540.1 - 0.027 13.7 0.3 0.027 13.7 0.3 1.9 3 0 0 3 3 3 0 Zeta toxin IstB_IS21 PF01695.17 ETO08540.1 - 0.027 14.2 0.0 0.062 13.0 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 ETO08540.1 - 0.052 13.3 0.1 0.098 12.4 0.1 1.5 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 ETO08540.1 - 0.069 12.9 0.1 0.14 11.9 0.1 1.7 1 1 0 1 1 1 0 DNA polymerase III, delta subunit AAA_29 PF13555.6 ETO08540.1 - 0.1 12.4 0.3 14 5.5 0.1 2.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain CbiA PF01656.23 ETO08540.1 - 0.12 12.4 0.3 0.44 10.6 0.1 1.9 2 0 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Thioredoxin_14 PF18402.1 ETO08541.1 - 0.088 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain Kelch_6 PF13964.6 ETO08541.1 - 0.09 13.1 0.1 0.82 10.1 0.1 2.5 2 0 0 2 2 2 0 Kelch motif SecD-TM1 PF13721.6 ETO08542.1 - 0.53 10.8 0.1 0.53 10.8 0.1 2.2 2 0 0 2 2 2 0 SecD export protein N-terminal TM region OCRE PF17780.1 ETO08543.1 - 2.7e-07 30.5 1.7 5e-07 29.6 1.7 1.4 1 0 0 1 1 1 1 OCRE domain LIFR_D2 PF17971.1 ETO08543.1 - 0.032 14.4 0.6 0.07 13.3 0.6 1.5 1 0 0 1 1 1 0 Leukemia inhibitory factor receptor D2 domain RRM_1 PF00076.22 ETO08544.1 - 6e-14 51.6 0.2 1.1e-05 25.1 0.0 2.9 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO08544.1 - 0.00038 20.5 0.0 1.2 9.4 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif zf-RanBP PF00641.18 ETO08544.1 - 0.0058 15.9 4.6 0.013 14.8 4.6 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RRM_3 PF08777.11 ETO08544.1 - 0.022 14.8 0.3 0.24 11.4 0.0 2.8 2 1 0 2 2 2 0 RNA binding motif Pepdidase_M14_N PF18027.1 ETO08547.1 - 0.022 15.1 0.0 0.039 14.3 0.0 1.4 1 0 0 1 1 1 0 Cytosolic carboxypeptidase N-terminal domain SH3_1 PF00018.28 ETO08549.1 - 0.0048 16.5 0.0 0.0091 15.6 0.0 1.4 1 0 0 1 1 1 1 SH3 domain Coat_F PF07875.12 ETO08549.1 - 0.0049 17.1 1.7 1.4 9.2 0.1 2.3 2 0 0 2 2 2 2 Coat F domain DUF658 PF04936.12 ETO08549.1 - 0.059 13.1 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF658) V-SNARE_C PF12352.8 ETO08549.1 - 0.064 13.6 1.5 1.3 9.4 0.1 3.1 3 0 0 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus DUF4537 PF15057.6 ETO08550.1 - 6.5e-06 26.2 0.1 4.4e-05 23.5 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) 53-BP1_Tudor PF09038.10 ETO08550.1 - 0.001 19.0 0.0 0.0031 17.5 0.0 1.8 1 0 0 1 1 1 1 Tumour suppressor p53-binding protein-1 Tudor SMN PF06003.12 ETO08550.1 - 0.0077 15.5 0.1 0.0077 15.5 0.1 2.9 4 0 0 4 4 4 1 Survival motor neuron protein (SMN) BclA_C PF18573.1 ETO08550.1 - 0.044 13.7 0.0 0.044 13.7 0.0 2.3 2 0 0 2 2 2 0 BclA C-terminal domain Agenet PF05641.12 ETO08550.1 - 0.064 13.7 0.2 1 9.9 0.0 2.7 2 1 0 2 2 2 0 Agenet domain Tudor_2 PF18104.1 ETO08550.1 - 0.089 12.5 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Jumonji domain-containing protein 2A Tudor domain TUDOR PF00567.24 ETO08550.1 - 1.6 8.8 7.6 0.49 10.4 0.2 3.4 2 2 1 3 3 3 0 Tudor domain DUF4140 PF13600.6 ETO08550.1 - 9.6 6.7 11.0 13 6.3 0.1 3.3 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) AAA_21 PF13304.6 ETO08551.1 - 6.6e-06 26.1 0.0 1.3e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 ETO08551.1 - 4.1e-05 24.2 0.1 6.8e-05 23.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4162) 7TM_GPCR_Sri PF10327.9 ETO08551.1 - 0.044 13.0 0.0 0.078 12.2 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sri CsrA PF02599.16 ETO08551.1 - 0.14 12.2 0.0 0.41 10.6 0.0 1.7 1 0 0 1 1 1 0 Global regulator protein family Zip PF02535.22 ETO08552.1 - 5.6e-39 134.3 15.1 7e-39 134.0 15.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter PMC2NT PF08066.12 ETO08553.1 - 0.66 10.7 5.2 1.3 9.8 1.0 3.4 2 0 0 2 2 2 0 PMC2NT (NUC016) domain DUF5082 PF16888.5 ETO08554.1 - 0.01 16.1 14.9 0.01 16.1 14.9 6.3 3 1 3 6 6 6 0 Domain of unknown function (DUF5082) ApoO PF09769.9 ETO08554.1 - 0.49 10.4 9.5 0.33 10.9 1.4 3.7 2 2 1 3 3 3 0 Apolipoprotein O DUF1320 PF07030.12 ETO08554.1 - 0.62 10.2 9.2 0.12 12.4 1.7 3.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1320) SATase_N PF06426.14 ETO08554.1 - 8.3 6.8 9.1 20 5.6 0.2 4.4 3 1 1 4 4 4 0 Serine acetyltransferase, N-terminal CbiA PF01656.23 ETO08554.1 - 9.6 6.3 14.5 0.41 10.7 6.2 2.8 2 2 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Kelch_6 PF13964.6 ETO08555.1 - 0.0066 16.7 2.3 2.6 8.5 0.1 4.1 6 0 0 6 6 6 2 Kelch motif Kelch_5 PF13854.6 ETO08555.1 - 0.27 11.3 1.9 34 4.6 0.0 4.0 5 0 0 5 5 5 0 Kelch motif DNA_pol_B PF00136.21 ETO08556.1 - 1.4e-78 264.6 6.2 1.9e-78 264.3 6.2 1.1 1 0 0 1 1 1 1 DNA polymerase family B zf-DNA_Pol PF08996.10 ETO08556.1 - 1.4e-42 145.5 3.9 3.1e-42 144.4 3.9 1.5 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger zinc_ribbon_4 PF13717.6 ETO08556.1 - 0.082 12.8 0.3 0.2 11.6 0.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain NPV_P10 PF05531.12 ETO08556.1 - 0.67 10.5 3.4 7.6 7.1 0.3 2.8 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DNA_pol_B_exo1 PF03104.19 ETO08557.1 - 8.6e-23 81.0 1.5 6.3e-22 78.1 1.5 2.0 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain WD40 PF00400.32 ETO08558.1 - 2e-47 158.2 4.4 3.5e-08 34.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08558.1 - 4.7e-15 55.7 0.1 1.6e-05 25.1 0.0 6.0 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08558.1 - 3.8e-11 42.5 0.4 0.071 12.1 0.0 5.6 2 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO08558.1 - 2.7e-07 30.6 0.2 9.9e-05 22.3 0.0 2.9 1 1 3 4 4 4 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO08558.1 - 2.4e-06 27.1 0.4 0.00038 19.9 0.0 3.3 1 1 3 4 4 4 2 WD40-like domain Nbas_N PF15492.6 ETO08558.1 - 0.0017 17.8 0.9 1.7 7.9 0.1 4.1 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO08558.1 - 0.0059 15.2 0.1 1.4 7.4 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO08558.1 - 0.031 13.0 4.2 2.1 7.0 0.5 2.8 1 1 1 2 2 2 0 Nup133 N terminal like DPPIV_N PF00930.21 ETO08558.1 - 0.034 12.9 0.1 3.9 6.1 0.0 3.0 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Gmad1 PF10647.9 ETO08558.1 - 0.052 13.3 0.1 0.33 10.6 0.0 2.3 2 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Striatin PF08232.12 ETO08559.1 - 0.023 15.3 1.1 0.031 14.9 1.1 1.3 1 0 0 1 1 1 0 Striatin family Menin PF05053.13 ETO08559.1 - 0.13 10.6 9.8 0.17 10.2 9.8 1.1 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 ETO08559.1 - 0.44 9.0 7.2 0.47 9.0 7.2 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO08559.1 - 0.65 8.7 4.2 0.7 8.6 4.2 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 ETO08559.1 - 3.8 6.2 3.8 4.7 5.9 3.8 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF2076 PF09849.9 ETO08559.1 - 7.6 6.5 15.8 15 5.5 15.8 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MFS_2 PF13347.6 ETO08560.1 - 0.00011 20.9 0.0 0.00011 20.9 0.0 4.1 4 1 0 4 4 4 1 MFS/sugar transport protein FAM176 PF14851.6 ETO08560.1 - 0.0011 18.7 0.3 0.021 14.5 0.0 2.8 3 0 0 3 3 3 1 FAM176 family CENP-B_dimeris PF09026.10 ETO08560.1 - 0.88 10.0 7.1 2.1 8.8 7.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Ank_2 PF12796.7 ETO08561.1 - 5e-26 91.1 12.8 5.3e-08 33.3 0.1 5.0 3 2 2 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO08561.1 - 1.8e-24 85.8 0.8 4.8e-06 27.0 0.0 6.4 5 1 1 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ETO08561.1 - 4e-17 61.8 1.8 0.0011 19.3 0.0 6.5 6 0 0 6 6 6 4 Ankyrin repeat Ank_5 PF13857.6 ETO08561.1 - 1.1e-16 60.6 14.9 2.1e-06 27.9 0.0 6.8 5 2 2 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO08561.1 - 3.7e-16 57.6 1.6 9.6e-05 22.5 0.0 7.1 7 0 0 7 7 7 4 Ankyrin repeat Gb3_synth PF04572.12 ETO08561.1 - 0.055 13.6 0.4 0.61 10.3 0.1 2.3 2 0 0 2 2 2 0 Alpha 1,4-glycosyltransferase conserved region PA-IL PF07828.12 ETO08561.1 - 0.088 12.8 0.1 3.7 7.6 0.0 2.9 2 1 1 3 3 3 0 PA-IL-like protein Glyco_transf_8 PF01501.20 ETO08562.1 - 2e-05 24.3 6.8 0.002 17.7 6.8 2.3 1 1 0 1 1 1 1 Glycosyl transferase family 8 Smoothelin PF12510.8 ETO08563.1 - 0.14 12.3 0.8 14 5.8 0.1 3.1 3 0 0 3 3 3 0 Smoothelin cytoskeleton protein Secretin_N_2 PF07655.13 ETO08563.1 - 0.52 10.9 11.8 1.2 9.7 11.8 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain ATP-grasp_4 PF13535.6 ETO08564.1 - 0.00019 21.1 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain NOA36 PF06524.12 ETO08564.1 - 0.0017 17.7 6.9 0.0039 16.6 6.9 1.6 1 0 0 1 1 1 1 NOA36 protein CPSase_L_D2 PF02786.17 ETO08564.1 - 0.0036 16.8 0.0 0.0075 15.8 0.0 1.5 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.6 ETO08564.1 - 0.12 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon Sigma70_ner PF04546.13 ETO08564.1 - 0.13 12.2 4.0 0.32 10.8 4.0 1.7 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF3328 PF11807.8 ETO08565.1 - 0.0057 16.4 0.0 0.0093 15.8 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3328) VIR_N PF15912.5 ETO08565.1 - 0.03 13.9 0.2 0.038 13.6 0.2 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal Mito_fiss_reg PF05308.11 ETO08565.1 - 0.4 10.7 2.9 0.66 10.0 2.9 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator zinc_ribbon_15 PF17032.5 ETO08566.1 - 0.041 14.6 1.2 0.53 11.1 0.2 2.3 2 0 0 2 2 2 0 zinc-ribbon family SecG PF03840.14 ETO08566.1 - 0.17 12.0 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Preprotein translocase SecG subunit C2 PF00168.30 ETO08567.1 - 9.5e-12 45.1 0.2 2.4e-11 43.8 0.2 1.8 1 1 0 1 1 1 1 C2 domain WD40 PF00400.32 ETO08569.1 - 3.7e-08 33.9 1.4 0.025 15.5 0.1 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat CDC27 PF09507.10 ETO08570.1 - 2.7 7.3 37.4 3 7.1 37.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RR_TM4-6 PF06459.12 ETO08570.1 - 6.1 6.6 34.1 7.7 6.2 34.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RBD PF02196.15 ETO08571.1 - 0.00043 20.3 0.0 0.00074 19.6 0.0 1.3 1 0 0 1 1 1 1 Raf-like Ras-binding domain Zip PF02535.22 ETO08571.1 - 2.4 7.3 4.4 4.1 6.5 4.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter EF-hand_6 PF13405.6 ETO08572.1 - 0.054 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain PPL5 PF18168.1 ETO08572.1 - 0.95 8.7 12.0 0.6 9.3 1.6 2.0 2 0 0 2 2 2 0 Prim-pol family 5 DUF1664 PF07889.12 ETO08572.1 - 2.7 8.0 13.6 0.034 14.2 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Hydrolase_3 PF08282.12 ETO08572.1 - 7.5 6.2 11.7 0.36 10.5 4.2 2.0 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase HeLo PF14479.6 ETO08573.1 - 0.0046 16.8 1.0 0.0046 16.8 1.0 2.4 2 0 0 2 2 2 1 Prion-inhibition and propagation DUF1043 PF06295.12 ETO08573.1 - 0.01 15.8 3.6 0.01 15.8 3.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) GAT PF03127.14 ETO08573.1 - 0.095 13.0 0.3 0.095 13.0 0.3 2.9 3 0 0 3 3 3 0 GAT domain BPL_LplA_LipB PF03099.19 ETO08574.1 - 7.7e-07 29.1 0.3 5.1e-05 23.2 0.1 2.9 2 1 0 2 2 2 1 Biotin/lipoate A/B protein ligase family PIN_10 PF18478.1 ETO08574.1 - 0.12 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 PIN like domain Pkinase PF00069.25 ETO08575.1 - 7.4e-58 196.0 0.1 1.1e-57 195.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08575.1 - 1.6e-23 83.3 0.0 2.4e-23 82.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO08575.1 - 1.7e-05 24.3 0.6 3.2e-05 23.4 0.1 1.7 2 1 0 2 2 2 1 Kinase-like APH PF01636.23 ETO08575.1 - 0.05 13.5 0.0 0.079 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ndufs5 PF10200.9 ETO08575.1 - 0.058 13.7 0.5 1.2 9.5 0.1 3.0 2 1 1 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa cNMP_binding PF00027.29 ETO08576.1 - 4.7e-18 65.1 0.0 2.1e-17 63.0 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Orf78 PF06024.12 ETO08579.1 - 0.24 11.7 0.1 0.24 11.7 0.1 2.8 3 1 1 4 4 4 0 Orf78 (ac78) DUF4207 PF13904.6 ETO08579.1 - 3.1 7.4 9.6 0.54 9.9 0.2 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4207) Baculo_11_kDa PF06143.11 ETO08579.1 - 3.5 7.3 6.0 2.4 7.8 1.6 2.6 2 0 0 2 2 2 0 Baculovirus 11 kDa family TPMT PF05724.11 ETO08581.1 - 1.4e-07 31.4 0.4 6.5e-05 22.7 0.1 2.5 1 1 1 2 2 2 2 Thiopurine S-methyltransferase (TPMT) Malic_M PF03949.15 ETO08582.1 - 1.5e-27 96.5 0.0 1.6e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain TPMT PF05724.11 ETO08583.1 - 6.5e-10 39.0 0.2 1.1e-08 35.1 0.0 2.3 2 1 1 3 3 3 1 Thiopurine S-methyltransferase (TPMT) AIP3 PF03915.13 ETO08583.1 - 0.015 14.4 0.1 0.019 14.1 0.1 1.2 1 0 0 1 1 1 0 Actin interacting protein 3 Metallophos PF00149.28 ETO08585.1 - 6.3e-30 105.2 0.1 9e-30 104.7 0.1 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO08585.1 - 4.2e-16 59.1 1.6 9.6e-16 58.0 1.6 1.7 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain CRA PF06589.11 ETO08585.1 - 0.083 13.0 4.1 0.21 11.7 0.0 2.4 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) malic PF00390.19 ETO08586.1 - 1.6e-10 41.1 0.0 2.3e-10 40.6 0.0 1.2 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain malic PF00390.19 ETO08587.1 - 5.6e-34 117.5 0.0 7.4e-34 117.1 0.0 1.1 1 0 0 1 1 1 1 Malic enzyme, N-terminal domain NatB_MDM20 PF09797.9 ETO08589.1 - 1.4e-22 80.2 0.1 1.4e-22 80.2 0.1 1.7 2 0 0 2 2 2 1 N-acetyltransferase B complex (NatB) non catalytic subunit SAS4 PF15460.6 ETO08589.1 - 1.6 8.9 5.8 26 5.0 3.1 3.0 2 1 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 Orbi_NS1 PF01718.16 ETO08590.1 - 0.015 13.8 0.0 0.058 11.9 0.0 1.8 2 0 0 2 2 2 0 Orbivirus non-structural protein NS1, or hydrophobic tubular protein PQ-loop PF04193.14 ETO08591.1 - 4.7e-05 23.1 1.0 9.8e-05 22.1 1.0 1.6 1 0 0 1 1 1 1 PQ loop repeat Methyltr_RsmF_N PF17125.5 ETO08592.1 - 0.82 10.2 4.3 0.77 10.3 0.5 2.6 1 1 1 2 2 2 0 N-terminal domain of 16S rRNA methyltransferase RsmF EF-hand_6 PF13405.6 ETO08593.1 - 9.7e-06 25.1 4.7 0.037 14.0 0.0 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO08593.1 - 0.00066 19.1 4.6 0.0052 16.2 0.0 3.6 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 ETO08593.1 - 0.0026 17.5 0.6 0.017 14.9 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain pair DUF4424 PF14415.6 ETO08593.1 - 0.0084 15.4 1.2 0.017 14.4 1.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4424) EF-hand_1 PF00036.32 ETO08593.1 - 0.0098 15.4 0.0 0.0098 15.4 0.0 3.7 5 0 0 5 5 5 1 EF hand EF-hand_7 PF13499.6 ETO08593.1 - 0.012 16.0 3.0 0.012 16.0 3.0 2.8 2 1 0 2 2 2 0 EF-hand domain pair Nop14 PF04147.12 ETO08594.1 - 2.4e-05 22.8 31.2 2.8e-05 22.6 31.2 1.3 1 0 0 1 1 1 1 Nop14-like family DUF4834 PF16118.5 ETO08594.1 - 0.0019 19.1 0.4 0.0019 19.1 0.4 2.9 2 1 1 3 3 3 1 Domain of unknown function (DUF4834) SID-1_RNA_chan PF13965.6 ETO08594.1 - 0.0036 15.8 3.5 0.0041 15.6 3.5 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Zip PF02535.22 ETO08594.1 - 0.0092 15.2 8.3 0.014 14.7 8.3 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter CobT PF06213.12 ETO08594.1 - 0.1 12.0 31.0 0.21 10.9 31.0 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pept_S41_N PF18294.1 ETO08594.1 - 6.5 6.8 12.6 0.43 10.6 4.5 2.8 2 1 1 3 3 3 0 Peptidase S41 N-terminal domain Serinc PF03348.15 ETO08594.1 - 6.9 5.5 7.5 5 5.9 6.0 1.6 1 1 0 1 1 1 0 Serine incorporator (Serinc) Catalase-rel PF06628.12 ETO08595.1 - 0.087 13.0 0.3 5.2 7.4 0.0 2.5 2 0 0 2 2 2 0 Catalase-related immune-responsive DUF4481 PF14800.6 ETO08595.1 - 0.098 12.1 0.6 0.15 11.5 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) Ig_Tie2_1 PF10430.9 ETO08595.1 - 0.13 12.7 0.1 0.13 12.7 0.1 2.3 3 0 0 3 3 3 0 Tie-2 Ig-like domain 1 HMG_box PF00505.19 ETO08595.1 - 1.8 9.0 26.6 0.28 11.6 2.4 4.5 3 2 0 3 3 3 0 HMG (high mobility group) box Cyt-b5 PF00173.28 ETO08597.1 - 4.1e-19 68.5 0.0 6.9e-19 67.8 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Myc_N PF01056.18 ETO08597.1 - 0.0031 17.5 7.3 0.0037 17.2 7.3 1.1 1 0 0 1 1 1 1 Myc amino-terminal region DUF3474 PF11960.8 ETO08597.1 - 0.36 11.0 5.7 0.58 10.4 3.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) Astro_capsid_p PF12226.8 ETO08597.1 - 0.39 9.8 12.7 0.49 9.5 12.7 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RR_TM4-6 PF06459.12 ETO08597.1 - 0.59 9.9 12.5 0.76 9.6 12.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 ETO08597.1 - 0.63 10.4 18.8 0.89 9.9 18.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 ETO08597.1 - 1.6 7.4 13.3 1.9 7.2 13.3 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO08597.1 - 1.7 7.8 9.2 1.8 7.7 9.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETO08597.1 - 3.8 6.8 12.6 5.1 6.3 12.6 1.2 1 0 0 1 1 1 0 NOA36 protein RNA_polI_A34 PF08208.11 ETO08597.1 - 4.3 7.4 19.5 5.7 7.0 19.5 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF913 PF06025.12 ETO08597.1 - 5.8 5.8 9.4 7.1 5.5 9.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GET2 PF08690.10 ETO08597.1 - 9.5 5.8 12.2 12 5.5 12.2 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 IDEAL PF08858.10 ETO08598.1 - 1.4 8.7 6.3 0.19 11.5 1.3 2.1 2 0 0 2 2 2 0 IDEAL domain Transposase_28 PF04195.12 ETO08600.1 - 0.047 13.9 0.1 0.047 13.9 0.1 2.5 2 0 0 2 2 2 0 Putative gypsy type transposon AAA PF00004.29 ETO08602.1 - 1.4e-12 48.2 0.1 4.5e-05 23.9 0.0 4.0 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO08602.1 - 2.4e-08 34.3 0.0 0.0065 16.7 0.0 4.2 3 1 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ETO08602.1 - 5.6e-08 32.5 0.1 0.0019 17.8 0.0 3.1 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO08602.1 - 8.2e-07 29.1 0.0 0.011 15.7 0.0 3.5 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO08602.1 - 1.9e-05 25.2 0.2 0.012 16.0 0.0 4.1 3 1 1 4 4 4 1 AAA ATPase domain IstB_IS21 PF01695.17 ETO08602.1 - 4.5e-05 23.3 0.7 0.013 15.2 0.0 3.9 4 0 0 4 4 4 1 IstB-like ATP binding protein AAA_14 PF13173.6 ETO08602.1 - 0.00014 21.9 0.9 0.024 14.7 0.0 4.2 3 1 1 4 4 4 1 AAA domain AAA_8 PF12780.7 ETO08602.1 - 0.0016 17.9 2.7 0.0031 16.9 0.0 2.6 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 ABC_tran PF00005.27 ETO08602.1 - 0.0019 18.7 0.3 0.017 15.7 0.0 2.8 3 0 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 ETO08602.1 - 0.0036 17.2 0.0 0.012 15.6 0.0 1.9 1 0 0 1 1 1 1 RsgA GTPase DUF815 PF05673.13 ETO08602.1 - 0.0041 16.3 0.0 0.055 12.6 0.0 2.8 3 0 0 3 3 3 1 Protein of unknown function (DUF815) MCM PF00493.23 ETO08602.1 - 0.0046 16.1 0.3 0.59 9.2 0.0 2.9 3 0 0 3 3 3 1 MCM P-loop domain NACHT PF05729.12 ETO08602.1 - 0.0066 16.4 0.2 1.2 9.0 0.0 3.6 3 0 0 3 3 3 1 NACHT domain AAA_19 PF13245.6 ETO08602.1 - 0.02 15.2 0.4 17 5.8 0.0 3.4 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 ETO08602.1 - 0.031 14.3 0.1 0.32 11.0 0.0 2.6 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Thioredoxin_12 PF18400.1 ETO08602.1 - 0.039 13.8 0.1 0.46 10.3 0.1 2.8 2 0 0 2 2 2 0 Thioredoxin-like domain PduV-EutP PF10662.9 ETO08602.1 - 0.048 13.4 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 ETO08602.1 - 0.08 12.6 0.0 1 9.1 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETO08602.1 - 0.11 13.0 0.0 7.7 7.0 0.0 3.3 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 ETO08602.1 - 0.15 11.8 0.0 29 4.3 0.0 3.4 3 1 0 3 3 3 0 AAA domain Ntox35 PF15534.6 ETO08603.1 - 0.016 15.6 2.6 0.048 14.1 0.1 2.4 3 0 0 3 3 3 0 Bacterial toxin 35 Sugar_tr PF00083.24 ETO08605.1 - 1.2e-17 63.9 9.9 1.6e-17 63.5 9.9 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETO08605.1 - 2.5e-14 53.0 12.7 3e-14 52.7 12.7 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TRI12 PF06609.13 ETO08605.1 - 1.6e-05 23.5 4.2 2.1e-05 23.1 4.2 1.1 1 0 0 1 1 1 1 Fungal trichothecene efflux pump (TRI12) MFS_2 PF13347.6 ETO08605.1 - 0.0021 16.7 8.8 0.0074 14.9 8.7 2.1 1 1 0 1 1 1 1 MFS/sugar transport protein ECH_1 PF00378.20 ETO08607.1 - 1e-27 97.1 0.0 1.8e-27 96.3 0.0 1.4 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO08607.1 - 6.2e-15 55.5 0.0 1.6e-14 54.1 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Psu PF07455.11 ETO08607.1 - 0.059 13.0 0.0 0.32 10.6 0.0 1.9 2 0 0 2 2 2 0 Phage polarity suppression protein (Psu) Init_tRNA_PT PF04179.12 ETO08607.1 - 0.077 13.3 0.0 0.22 11.8 0.0 1.7 1 0 0 1 1 1 0 Rit1 DUSP-like domain Peptidase_S49 PF01343.18 ETO08607.1 - 0.12 12.4 0.2 11 6.0 0.0 2.7 3 0 0 3 3 3 0 Peptidase family S49 zf-TRAF PF02176.18 ETO08608.1 - 3.3e-06 27.7 3.8 3.3e-06 27.7 3.8 2.7 3 0 0 3 3 3 1 TRAF-type zinc finger YabA PF06156.13 ETO08608.1 - 0.41 11.3 8.6 6.4 7.5 8.6 2.5 1 1 0 1 1 1 0 Initiation control protein YabA FGAR-AT_linker PF18072.1 ETO08608.1 - 0.74 10.4 3.2 2.3 8.8 0.2 2.8 3 0 0 3 3 3 0 Formylglycinamide ribonucleotide amidotransferase linker domain Cnn_1N PF07989.11 ETO08608.1 - 4.1 7.6 12.9 19 5.5 10.7 2.6 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 UPF0242 PF06785.11 ETO08608.1 - 4.6 7.3 16.6 9.2 6.3 16.5 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Kelch_4 PF13418.6 ETO08609.1 - 0.00016 21.6 0.3 0.031 14.3 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO08609.1 - 0.00046 20.0 1.8 1.8 8.7 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO08609.1 - 0.0005 20.3 0.9 2.9 8.3 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO08609.1 - 0.0011 18.5 1.6 0.02 14.5 0.2 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO08609.1 - 0.53 10.3 2.3 1.2e+02 2.8 0.4 4.0 5 0 0 5 5 5 0 Kelch motif B56 PF01603.20 ETO08611.1 - 9.6e-154 512.3 16.5 4.5e-153 510.1 16.5 1.8 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RXT2_N PF08595.11 ETO08611.1 - 0.033 14.2 1.0 0.073 13.1 0.2 2.0 2 0 0 2 2 2 0 RXT2-like, N-terminal Ins_P5_2-kin PF06090.12 ETO08611.1 - 0.19 11.1 2.7 0.26 10.7 0.2 2.1 2 1 0 2 2 2 0 Inositol-pentakisphosphate 2-kinase SelK_SelG PF10961.8 ETO08612.1 - 0.19 12.3 0.0 0.48 11.1 0.0 1.7 1 0 0 1 1 1 0 Selenoprotein SelK_SelG GAGA_bind PF06217.12 ETO08613.1 - 0.44 10.8 7.0 0.72 10.1 7.0 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family DUF4629 PF15442.6 ETO08613.1 - 5.1 7.3 19.1 16 5.7 19.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4629) Robl_LC7 PF03259.17 ETO08614.1 - 2.2e-06 27.4 0.0 4.4e-05 23.2 0.0 2.1 1 1 0 1 1 1 1 Roadblock/LC7 domain LAMTOR5 PF16672.5 ETO08614.1 - 0.012 15.5 0.0 0.018 14.9 0.0 1.2 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Tai4 PF16695.5 ETO08615.1 - 0.13 12.8 0.5 0.67 10.5 0.2 2.1 1 1 1 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein Mpp10 PF04006.12 ETO08618.1 - 0.043 12.3 36.3 0.064 11.7 36.3 1.2 1 0 0 1 1 1 0 Mpp10 protein Caldesmon PF02029.15 ETO08618.1 - 0.06 12.1 43.8 0.078 11.7 43.8 1.1 1 0 0 1 1 1 0 Caldesmon TFIIA PF03153.13 ETO08618.1 - 0.15 12.0 28.1 0.18 11.8 28.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apt1 PF10351.9 ETO08618.1 - 0.71 8.7 17.1 0.89 8.3 17.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Dapper PF15268.6 ETO08618.1 - 0.93 8.3 24.1 1.1 8.1 24.1 1.1 1 0 0 1 1 1 0 Dapper Mitofilin PF09731.9 ETO08618.1 - 2.5 6.8 31.1 3.2 6.5 31.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Raftlin PF15250.6 ETO08618.1 - 2.9 6.5 20.1 4.6 5.9 20.1 1.3 1 0 0 1 1 1 0 Raftlin DUF4407 PF14362.6 ETO08618.1 - 8 5.7 16.5 9.7 5.4 16.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SLC12 PF03522.15 ETO08618.1 - 10 5.0 28.2 15 4.4 28.2 1.2 1 1 0 1 1 1 0 Solute carrier family 12 VP7 PF00434.18 ETO08619.1 - 0.39 9.8 3.7 0.61 9.2 3.7 1.3 1 0 0 1 1 1 0 Glycoprotein VP7 Retinal PF15449.6 ETO08620.1 - 0.00023 19.1 38.4 0.0019 16.1 25.8 2.0 1 1 1 2 2 2 2 Retinal protein DUF4573 PF15140.6 ETO08620.1 - 0.038 13.8 13.4 0.15 11.9 3.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4573) WD40 PF00400.32 ETO08621.1 - 0.0043 17.9 0.3 1.7 9.6 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat SatRNA_48 PF17485.2 ETO08622.1 - 2.4e-05 23.6 0.8 2.9e-05 23.3 0.8 1.1 1 0 0 1 1 1 1 Satellite RNA 48 kDa protein LRR_4 PF12799.7 ETO08623.1 - 1.8e-05 25.0 18.4 0.00053 20.3 3.7 4.7 2 1 4 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO08623.1 - 5e-05 23.0 25.8 0.00065 19.4 5.5 4.5 3 1 3 6 6 6 3 Leucine rich repeat LRR_1 PF00560.33 ETO08623.1 - 0.066 13.8 12.4 17 6.5 0.4 6.1 5 0 0 5 5 5 0 Leucine Rich Repeat Pkinase PF00069.25 ETO08624.1 - 1.8e-32 112.8 0.2 2.3e-19 69.8 0.3 2.4 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08624.1 - 1.7e-08 34.1 0.0 1.4e-07 31.1 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO08624.1 - 0.00054 18.8 0.4 0.001 18.0 0.4 1.5 1 1 0 1 1 1 1 Fungal protein kinase zf-RVT PF13966.6 ETO08625.1 - 0.0099 16.6 0.1 0.028 15.1 0.0 1.8 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase Aldo_ket_red PF00248.21 ETO08626.1 - 5.2e-31 107.9 0.0 7.9e-31 107.3 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family Pkinase PF00069.25 ETO08627.1 - 8.1e-36 123.7 0.0 1.2e-35 123.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08627.1 - 1.3e-20 73.8 0.0 1.3e-19 70.5 0.0 2.0 1 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO08627.1 - 6.1e-07 29.0 0.3 1e-06 28.3 0.3 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO08627.1 - 0.0017 18.0 0.1 0.0031 17.1 0.1 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ETO08627.1 - 0.0042 16.1 0.1 0.007 15.3 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETO08627.1 - 0.068 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO08627.1 - 0.13 11.6 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like CDC45 PF02724.14 ETO08628.1 - 0.0083 14.5 1.6 0.0088 14.4 1.6 1.1 1 0 0 1 1 1 1 CDC45-like protein Bro-N PF02498.17 ETO08628.1 - 0.048 14.4 0.9 0.098 13.3 0.9 1.5 1 0 0 1 1 1 0 BRO family, N-terminal domain AAA PF00004.29 ETO08630.1 - 3.8e-10 40.3 0.0 6.2e-06 26.7 0.0 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO08630.1 - 1.6e-07 31.7 0.0 0.0015 18.8 0.0 2.7 2 0 0 2 2 2 2 AAA domain AAA_7 PF12775.7 ETO08630.1 - 1.6e-07 31.0 0.1 0.0016 18.0 0.0 2.5 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO08630.1 - 2.1e-06 27.8 0.0 0.0023 18.0 0.0 3.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO08630.1 - 1.2e-05 25.8 0.1 0.011 16.1 0.0 3.2 2 1 1 3 3 3 1 AAA ATPase domain AAA_14 PF13173.6 ETO08630.1 - 4.8e-05 23.4 0.4 0.0011 19.1 0.0 3.1 2 1 1 3 3 3 1 AAA domain AAA_8 PF12780.7 ETO08630.1 - 8.4e-05 22.0 0.7 0.00052 19.4 0.0 2.6 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 DUF815 PF05673.13 ETO08630.1 - 0.00075 18.7 0.0 0.0029 16.8 0.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO08630.1 - 0.0011 19.5 2.9 0.0026 18.3 0.0 2.9 4 0 0 4 4 4 1 ABC transporter IstB_IS21 PF01695.17 ETO08630.1 - 0.0019 18.0 0.0 0.02 14.6 0.0 2.5 2 0 0 2 2 2 1 IstB-like ATP binding protein MCM PF00493.23 ETO08630.1 - 0.0022 17.1 0.1 0.52 9.4 0.0 2.9 3 0 0 3 3 3 1 MCM P-loop domain AAA_19 PF13245.6 ETO08630.1 - 0.0045 17.3 0.4 5.3 7.4 0.2 3.0 2 1 1 3 3 3 1 AAA domain Peptidase_S49_N PF08496.10 ETO08630.1 - 0.0052 16.8 3.3 0.013 15.5 3.3 1.6 1 0 0 1 1 1 1 Peptidase family S49 N-terminal TsaE PF02367.17 ETO08630.1 - 0.0085 16.1 0.0 0.081 12.9 0.0 2.4 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RsgA_GTPase PF03193.16 ETO08630.1 - 0.0095 15.9 0.1 0.021 14.7 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase PduV-EutP PF10662.9 ETO08630.1 - 0.013 15.2 0.2 0.052 13.3 0.1 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ETO08630.1 - 0.015 15.2 0.4 0.85 9.5 0.1 3.5 4 0 0 4 4 4 0 NACHT domain Sigma54_activat PF00158.26 ETO08630.1 - 0.049 13.3 0.0 0.98 9.1 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_21 PF13304.6 ETO08630.1 - 0.072 12.9 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Zeta_toxin PF06414.12 ETO08630.1 - 0.075 12.3 0.0 0.23 10.7 0.0 1.9 2 0 0 2 2 2 0 Zeta toxin AAA_24 PF13479.6 ETO08630.1 - 0.17 11.6 0.0 0.17 11.6 0.0 2.5 4 0 0 4 4 3 0 AAA domain Sigma70_ner PF04546.13 ETO08630.1 - 0.2 11.5 9.9 0.041 13.8 5.7 1.8 2 0 0 2 2 2 0 Sigma-70, non-essential region Mg_chelatase PF01078.21 ETO08630.1 - 0.2 11.0 0.1 12 5.2 0.1 2.7 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 ETO08630.1 - 0.32 11.5 13.4 0.49 10.9 0.2 2.9 3 0 0 3 3 3 0 AAA domain AAA_9 PF12781.7 ETO08631.1 - 0.00027 20.1 0.0 0.00057 19.1 0.0 1.6 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_5 PF07728.14 ETO08631.1 - 0.016 15.2 0.0 0.033 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Longin PF13774.6 ETO08631.1 - 0.27 11.3 1.7 15 5.7 0.1 3.2 2 1 1 3 3 3 0 Regulated-SNARE-like domain D5_N PF08706.11 ETO08634.1 - 0.024 14.9 0.0 0.047 13.9 0.0 1.5 1 1 0 1 1 1 0 D5 N terminal like SlyX PF04102.12 ETO08634.1 - 0.05 14.2 1.3 0.55 10.9 0.0 2.4 2 0 0 2 2 2 0 SlyX CNOT11 PF10155.9 ETO08634.1 - 0.05 13.8 1.6 0.3 11.2 0.1 2.2 2 0 0 2 2 2 0 CCR4-NOT transcription complex subunit 11 DUF641 PF04859.12 ETO08634.1 - 0.073 13.4 5.4 0.11 12.8 2.9 2.4 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF4407 PF14362.6 ETO08634.1 - 0.55 9.5 3.0 0.82 9.0 3.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 ETO08634.1 - 0.71 10.0 9.5 2.7 8.0 9.5 1.9 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Wx5_PLAF3D7 PF09688.10 ETO08634.1 - 1.4 9.0 10.3 0.17 11.9 0.7 3.0 2 2 1 3 3 3 0 Protein of unknown function (Wx5_PLAF3D7) DUF948 PF06103.11 ETO08634.1 - 1.6 9.0 4.6 0.92 9.8 0.3 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc24 PF08286.11 ETO08634.1 - 2.2 8.6 9.8 4.3 7.6 0.8 2.7 3 0 0 3 3 3 0 Spc24 subunit of Ndc80 DivIC PF04977.15 ETO08634.1 - 9.1 6.1 14.1 2.8 7.8 1.0 3.9 3 1 1 4 4 4 0 Septum formation initiator WD40 PF00400.32 ETO08635.1 - 7.6e-19 67.7 0.1 1.3e-05 25.8 0.0 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08635.1 - 3.8e-10 39.9 0.0 2.8e-05 24.3 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ubiquitin_3 PF14836.6 ETO08635.1 - 0.024 14.6 0.1 0.095 12.7 0.0 1.9 1 1 1 2 2 2 0 Ubiquitin-like domain Ge1_WD40 PF16529.5 ETO08635.1 - 0.032 13.2 0.0 0.4 9.6 0.0 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4477 PF14780.6 ETO08636.1 - 0.066 12.8 0.2 0.077 12.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) CAP_N PF01213.19 ETO08636.1 - 0.066 12.7 0.1 0.067 12.7 0.1 1.0 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Myb_DNA-bind_6 PF13921.6 ETO08636.1 - 0.14 12.5 1.5 0.25 11.6 0.7 1.8 1 1 1 2 2 2 0 Myb-like DNA-binding domain HEPN_Apea PF18739.1 ETO08638.1 - 0.0083 16.5 0.3 0.014 15.9 0.2 1.5 1 1 0 1 1 1 1 Apea-like HEPN DUF4145 PF13643.6 ETO08638.1 - 0.14 12.3 0.0 0.23 11.6 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4145) Vac14_Fab1_bd PF12755.7 ETO08640.1 - 0.32 11.6 3.0 14 6.4 0.1 2.2 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region WD40 PF00400.32 ETO08641.1 - 7.6e-30 102.5 39.5 3e-07 31.0 0.6 9.4 7 4 1 8 8 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08641.1 - 3.4e-10 40.1 1.5 0.0013 19.0 0.0 5.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO08641.1 - 1.4e-05 25.6 2.2 1.4e-05 25.6 2.2 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger DUF812 PF05667.11 ETO08641.1 - 0.0034 16.4 12.1 0.0051 15.8 12.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF812) MPS2 PF17060.5 ETO08641.1 - 0.023 14.0 6.8 0.039 13.2 6.8 1.3 1 0 0 1 1 1 0 Monopolar spindle protein 2 Pox_G5 PF04599.12 ETO08641.1 - 0.23 10.4 6.0 0.42 9.6 6.0 1.3 1 0 0 1 1 1 0 Poxvirus G5 protein DUF489 PF04356.12 ETO08641.1 - 0.33 11.0 9.1 0.64 10.0 9.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF489) TRAF_BIRC3_bd PF16673.5 ETO08641.1 - 0.47 10.3 7.1 1.2 9.0 7.1 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor BIRC3 binding domain DUF4407 PF14362.6 ETO08641.1 - 0.79 9.0 16.8 1.6 8.0 16.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMF_TATA_bd PF12325.8 ETO08641.1 - 1 9.6 16.0 5.5 7.2 14.9 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF641 PF04859.12 ETO08641.1 - 4.2 7.7 14.2 24 5.3 8.6 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF724 PF05266.14 ETO08641.1 - 5.1 6.9 12.7 26 4.5 13.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF724) PPR_2 PF13041.6 ETO08642.1 - 0.00014 22.0 0.0 0.00032 20.8 0.0 1.6 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 ETO08642.1 - 0.00029 20.9 0.0 0.0013 18.8 0.0 2.2 1 0 0 1 1 1 1 PPR repeat PPR_1 PF12854.7 ETO08642.1 - 0.0032 17.1 0.2 0.007 16.0 0.2 1.6 1 0 0 1 1 1 1 PPR repeat RGS PF00615.19 ETO08642.1 - 0.11 12.8 0.6 0.81 10.0 0.0 2.6 2 0 0 2 2 2 0 Regulator of G protein signaling domain SNF2_N PF00176.23 ETO08643.1 - 4.3e-67 226.3 4.2 1e-65 221.8 4.2 2.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO08643.1 - 9.6e-16 58.1 0.0 4.3e-15 56.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO08643.1 - 0.00014 21.9 5.6 0.011 15.8 5.6 3.0 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit Prok-RING_4 PF14447.6 ETO08643.1 - 0.073 12.9 0.3 0.2 11.5 0.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 CoA_transf_3 PF02515.17 ETO08644.1 - 1e-25 90.7 0.0 1.1e-25 90.5 0.0 1.0 1 0 0 1 1 1 1 CoA-transferase family III FAM176 PF14851.6 ETO08645.1 - 0.0048 16.6 0.2 0.64 9.7 0.1 2.2 2 0 0 2 2 2 2 FAM176 family O-antigen_lig PF13425.6 ETO08645.1 - 0.14 10.9 1.7 0.2 10.4 1.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ring_hydroxyl_A PF00848.19 ETO08646.1 - 6e-30 104.8 0.0 1.7e-29 103.4 0.0 1.6 2 0 0 2 2 2 1 Ring hydroxylating alpha subunit (catalytic domain) Myb_DNA-binding PF00249.31 ETO08647.1 - 0.0003 20.9 0.1 0.00063 19.9 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO08647.1 - 0.00085 19.5 0.3 0.0017 18.6 0.3 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF2624 PF11116.8 ETO08647.1 - 0.038 14.9 4.4 0.046 14.6 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) Cu PF17563.2 ETO08647.1 - 0.67 10.2 3.4 29 5.0 1.5 2.7 2 0 0 2 2 2 0 Cupiennin LRR_4 PF12799.7 ETO08650.1 - 2.1 8.9 7.4 0.28 11.7 0.5 3.0 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) PRP38_assoc PF12871.7 ETO08651.1 - 0.0094 16.5 56.1 0.0094 16.5 56.1 2.0 1 1 1 2 2 2 2 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF913 PF06025.12 ETO08651.1 - 1.2 8.0 5.5 1.7 7.5 5.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO08651.1 - 3.8 6.2 20.1 4.2 6.1 20.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S64 PF08192.11 ETO08651.1 - 3.9 5.8 7.8 4.1 5.8 7.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 Presenilin PF01080.17 ETO08651.1 - 4.1 6.1 15.6 4.4 6.0 15.6 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO08651.1 - 5.7 6.7 14.3 8.6 6.1 14.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Merozoite_SPAM PF07133.11 ETO08651.1 - 6.8 6.6 22.2 8.7 6.3 22.2 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) HSP70 PF00012.20 ETO08652.1 - 2e-20 72.5 1.8 5.9e-20 71.0 0.1 2.0 2 0 0 2 2 2 1 Hsp70 protein SpoIID PF08486.10 ETO08652.1 - 0.062 13.9 0.1 0.12 13.0 0.1 1.4 1 0 0 1 1 1 0 Stage II sporulation protein Proteasom_Rpn13 PF04683.13 ETO08653.1 - 1.2e-10 41.8 0.4 4.4e-10 40.0 0.0 2.1 2 1 0 2 2 2 1 Proteasome complex subunit Rpn13 ubiquitin receptor DMA PF03474.14 ETO08653.1 - 3e-07 29.9 0.0 0.00022 20.7 0.0 2.4 2 0 0 2 2 2 2 DMRTA motif CUE PF02845.16 ETO08653.1 - 6.3e-07 29.0 0.2 0.0013 18.4 0.2 2.6 2 0 0 2 2 2 2 CUE domain HTH_8 PF02954.19 ETO08653.1 - 0.02 14.7 0.0 0.28 11.0 0.0 2.4 2 0 0 2 2 2 0 Bacterial regulatory protein, Fis family Mucin PF01456.17 ETO08653.1 - 1.8 8.5 12.0 1.4 8.9 6.9 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein GtrA PF04138.14 ETO08656.1 - 0.0022 18.2 9.5 0.013 15.8 9.4 2.2 1 1 2 3 3 3 2 GtrA-like protein DUF4229 PF14012.6 ETO08656.1 - 0.048 13.8 1.9 0.067 13.3 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4229) 2OG-FeII_Oxy_2 PF13532.6 ETO08657.1 - 7.5e-09 36.0 0.2 6.9e-07 29.7 0.2 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CDC37_N PF03234.14 ETO08658.1 - 0.0038 18.1 3.5 0.0038 18.1 3.5 2.2 2 0 0 2 2 2 1 Cdc37 N terminal kinase binding FPP PF05911.11 ETO08658.1 - 0.011 14.0 13.0 0.0085 14.3 11.1 1.6 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil AAA_23 PF13476.6 ETO08658.1 - 0.025 15.1 12.3 0.034 14.7 12.3 1.1 1 0 0 1 1 1 0 AAA domain Rx_N PF18052.1 ETO08658.1 - 0.11 12.8 5.0 0.21 11.9 4.5 1.7 1 1 0 1 1 1 0 Rx N-terminal domain Phage_GPO PF05929.11 ETO08658.1 - 0.18 11.4 8.4 0.22 11.1 8.4 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF3461 PF11944.8 ETO08658.1 - 0.58 10.3 7.4 0.43 10.7 5.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3461) ToxN_toxin PF13958.6 ETO08658.1 - 0.7 10.1 8.0 0.98 9.7 7.6 1.5 1 1 0 1 1 1 0 Toxin ToxN, type III toxin-antitoxin system NYD-SP28_assoc PF14775.6 ETO08658.1 - 0.76 9.9 5.3 1.7 8.8 5.3 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain bZIP_2 PF07716.15 ETO08658.1 - 2.2 8.5 8.8 2.5 8.3 7.6 1.8 1 1 0 1 1 1 0 Basic region leucine zipper Med21 PF11221.8 ETO08659.1 - 7.5e-07 29.5 7.8 8.3e-07 29.4 7.8 1.1 1 0 0 1 1 1 1 Subunit 21 of Mediator complex Epsilon_antitox PF08998.11 ETO08659.1 - 0.034 14.4 1.3 0.044 14.1 1.3 1.3 1 0 0 1 1 1 0 Bacterial epsilon antitoxin KIP1 PF07765.12 ETO08659.1 - 0.62 10.2 5.2 4.5 7.5 1.5 2.3 1 1 1 2 2 2 0 KIP1-like protein HU-CCDC81_bac_2 PF18175.1 ETO08661.1 - 0.0013 18.6 0.5 0.0046 16.8 0.5 2.1 1 0 0 1 1 1 1 CCDC81-like prokaryotic HU domain 2 HisKA PF00512.25 ETO08661.1 - 0.024 14.7 0.4 0.94 9.6 0.0 2.4 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF5347 PF17282.2 ETO08661.1 - 4.4 7.7 9.2 8 6.8 3.5 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5347) TPR_2 PF07719.17 ETO08662.1 - 3.3e-16 58.0 18.0 3.2e-05 23.7 1.0 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO08662.1 - 4.9e-14 51.5 15.7 8.3e-05 22.3 0.6 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO08662.1 - 1.2e-11 44.2 17.6 0.0011 19.1 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO08662.1 - 1.2e-09 37.6 16.4 0.051 13.8 0.3 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_12 PF13424.6 ETO08662.1 - 2e-08 34.4 17.2 0.047 14.0 1.0 4.9 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO08662.1 - 1e-06 29.1 6.9 0.0014 19.1 0.0 3.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO08662.1 - 2.1e-06 28.0 13.3 0.86 10.4 0.2 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO08662.1 - 2.8e-06 27.0 7.0 0.97 9.6 0.2 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO08662.1 - 5.9e-06 25.9 11.1 0.49 10.1 0.5 5.3 4 1 1 5 5 5 3 TPR repeat TPR_14 PF13428.6 ETO08662.1 - 2.4e-05 24.8 1.3 1.4 9.9 0.0 4.7 2 1 3 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO08662.1 - 9.3e-05 22.6 20.5 0.027 14.7 8.7 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO08662.1 - 0.0001 22.9 3.9 0.095 13.4 0.1 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO08662.1 - 0.00016 21.0 7.5 0.61 9.3 0.0 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TNF PF00229.18 ETO08662.1 - 0.078 12.9 3.7 0.046 13.7 1.5 1.7 2 0 0 2 2 2 0 TNF(Tumour Necrosis Factor) family TPR_10 PF13374.6 ETO08662.1 - 0.16 11.9 9.2 17 5.4 0.0 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat CSN8_PSD8_EIF3K PF10075.9 ETO08663.1 - 9.7e-16 58.0 0.1 1.1e-15 57.8 0.1 1.0 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Imm41 PF15592.6 ETO08663.1 - 0.0055 17.0 0.1 0.0072 16.7 0.1 1.2 1 0 0 1 1 1 1 Immunity protein 41 WD40 PF00400.32 ETO08664.1 - 5.3e-112 362.5 43.9 6.4e-09 36.3 0.0 16.4 15 1 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08664.1 - 5.1e-26 90.8 11.4 0.013 15.8 0.1 10.7 3 3 6 10 10 10 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08664.1 - 2.6e-15 56.2 6.6 0.1 11.5 0.0 10.9 3 3 9 12 12 12 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO08664.1 - 3.3e-11 42.6 26.7 0.94 8.0 0.3 11.3 3 3 7 11 11 11 6 Nucleoporin Nup120/160 NACHT PF05729.12 ETO08664.1 - 7.8e-08 32.4 0.0 1.6e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO08664.1 - 1.5e-06 27.7 4.5 3.5e-06 26.6 4.5 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 ETO08664.1 - 0.00021 21.4 2.0 0.00031 20.8 0.9 1.9 2 0 0 2 2 1 1 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 ETO08664.1 - 0.00041 20.5 0.3 0.0012 19.0 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO08664.1 - 0.0014 17.2 0.5 0.44 9.0 0.0 3.5 3 1 1 4 4 4 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO08664.1 - 0.009 15.9 17.1 15 5.6 0.5 7.7 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat DUF1854 PF08909.11 ETO08664.1 - 0.0099 15.7 0.7 24 4.7 0.0 5.1 4 2 1 6 6 5 0 Domain of unknown function (DUF1854) AAA_18 PF13238.6 ETO08664.1 - 0.012 16.1 0.0 0.089 13.3 0.0 2.6 2 0 0 2 2 1 0 AAA domain RsgA_GTPase PF03193.16 ETO08664.1 - 0.015 15.2 0.0 0.059 13.3 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase AAA_22 PF13401.6 ETO08664.1 - 0.021 15.1 0.0 0.091 13.0 0.0 2.2 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO08664.1 - 0.1 12.6 0.0 0.33 11.0 0.0 1.8 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETO08664.1 - 0.2 12.1 1.3 0.67 10.4 0.0 2.6 3 0 0 3 3 2 0 RNA helicase DUF5570 PF17731.1 ETO08664.1 - 0.46 10.6 16.6 9.1 6.4 0.0 7.7 6 4 5 11 11 9 0 Family of unknown function (DUF5570) RelA_SpoT PF04607.17 ETO08664.1 - 1.2 9.4 11.2 0.029 14.7 1.3 2.9 3 0 0 3 3 3 0 Region found in RelA / SpoT proteins CAP_GLY PF01302.25 ETO08665.1 - 7.2e-18 64.4 0.6 1.1e-17 63.8 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain Glycos_transf_2 PF00535.26 ETO08666.1 - 1.5e-30 106.2 0.2 3.3e-30 105.1 0.2 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ETO08666.1 - 4e-14 53.1 0.0 6.2e-14 52.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ETO08666.1 - 1.4e-07 31.3 4.1 1.4e-07 31.3 4.1 2.1 2 1 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ETO08666.1 - 0.0017 18.8 0.2 0.0046 17.4 0.2 1.8 1 0 0 1 1 1 1 Glycosyl transferase family 2 adh_short PF00106.25 ETO08666.1 - 0.18 11.2 0.4 1.6 8.1 0.0 2.1 2 0 0 2 2 2 0 short chain dehydrogenase TFIIE-A_C PF11521.8 ETO08668.1 - 0.022 15.0 0.5 0.036 14.3 0.5 1.3 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha NOA36 PF06524.12 ETO08668.1 - 1.6 8.0 8.3 4.6 6.5 4.8 2.0 2 0 0 2 2 2 0 NOA36 protein FOG_N PF15888.5 ETO08668.1 - 2.3 8.6 6.9 0.51 10.7 2.4 1.9 1 1 1 2 2 2 0 Folded gastrulation N-terminus zf-rbx1 PF12678.7 ETO08670.1 - 4.8e-14 52.4 12.1 4.8e-14 52.4 12.1 2.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO08670.1 - 2.2e-07 30.8 9.0 2.2e-07 30.8 9.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger ubiquitin PF00240.23 ETO08670.1 - 0.00019 21.1 4.6 0.00037 20.2 2.4 2.4 2 1 0 2 2 2 1 Ubiquitin family zf-RING_2 PF13639.6 ETO08670.1 - 0.00027 21.2 14.5 0.00027 21.2 14.5 2.9 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO08670.1 - 0.008 16.0 11.7 0.008 16.0 11.7 2.6 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Terminase_6C PF17289.2 ETO08670.1 - 0.012 15.7 0.5 0.025 14.7 0.1 1.7 2 0 0 2 2 2 0 Terminase RNaseH-like domain AGO_N PF18236.1 ETO08670.1 - 0.062 13.5 0.1 15 5.8 0.1 2.6 2 0 0 2 2 2 0 Argonaute N domain Imm-NTF2 PF15655.6 ETO08670.1 - 0.16 12.3 1.7 0.23 11.8 0.2 2.0 2 1 1 3 3 3 0 NTF2 fold immunity protein zf-RING-like PF08746.11 ETO08670.1 - 0.17 12.2 11.5 0.75 10.2 11.5 2.2 1 0 0 1 1 1 0 RING-like domain zf-RING_5 PF14634.6 ETO08670.1 - 0.19 11.7 14.7 0.87 9.6 14.7 2.3 1 1 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO08670.1 - 0.72 9.8 15.0 3.2 7.7 15.0 2.2 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO08670.1 - 2.7 8.1 9.0 8.6 6.5 9.0 2.0 1 0 0 1 1 1 0 RING-type zinc-finger RskA PF10099.9 ETO08671.1 - 0.023 15.0 6.9 0.044 14.1 6.9 1.4 1 0 0 1 1 1 0 Anti-sigma-K factor rskA CDC45 PF02724.14 ETO08672.1 - 7.1 4.8 15.6 11 4.1 15.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S49_N PF08496.10 ETO08673.1 - 0.049 13.7 7.5 0.06 13.4 7.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Connexin PF00029.19 ETO08673.1 - 0.47 10.2 4.1 0.56 9.9 4.1 1.1 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 ETO08673.1 - 1.9 7.2 6.6 2.2 7.0 6.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 ETO08673.1 - 2 7.9 8.6 2.4 7.6 8.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SPT6_acidic PF14632.6 ETO08673.1 - 3 8.5 13.1 0.63 10.7 3.5 2.1 1 1 1 2 2 2 0 Acidic N-terminal SPT6 PTEN_C2 PF10409.9 ETO08674.1 - 2.4e-07 30.5 2.2 7.2e-07 29.0 2.2 1.8 1 1 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein PTA_PTB PF01515.19 ETO08676.1 - 0.11 11.7 0.4 0.15 11.4 0.4 1.2 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase TPMT PF05724.11 ETO08677.1 - 3e-21 76.1 0.0 6.2e-21 75.1 0.0 1.5 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) Methyltransf_12 PF08242.12 ETO08677.1 - 0.00058 20.6 0.1 0.021 15.6 0.0 3.3 2 1 1 3 3 3 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO08677.1 - 0.0071 17.0 0.0 3.2 8.5 0.0 3.1 2 1 1 3 3 3 2 Methyltransferase domain Methyltransf_31 PF13847.6 ETO08677.1 - 0.0091 15.8 0.0 0.12 12.2 0.0 2.8 2 1 0 2 2 2 1 Methyltransferase domain Gp_dh_N PF00044.24 ETO08678.1 - 0.1 12.9 0.8 0.35 11.2 0.8 1.9 1 0 0 1 1 1 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Glyco_trans_2_3 PF13632.6 ETO08678.1 - 0.44 10.4 2.4 0.98 9.3 2.4 1.5 1 0 0 1 1 1 0 Glycosyl transferase family group 2 DUF3527 PF12043.8 ETO08679.1 - 0.013 15.1 0.4 0.02 14.5 0.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3527) Adenine_glyco PF03352.13 ETO08679.1 - 0.02 14.7 0.4 0.026 14.3 0.4 1.1 1 0 0 1 1 1 0 Methyladenine glycosylase Enterotoxin_ST PF02048.16 ETO08679.1 - 0.17 12.3 6.5 0.39 11.2 6.5 1.5 1 0 0 1 1 1 0 Heat-stable enterotoxin ST Peptidase_C97 PF05903.14 ETO08681.1 - 0.00095 19.0 0.1 0.0025 17.7 0.1 1.7 1 0 0 1 1 1 1 PPPDE putative peptidase domain CLN3 PF02487.17 ETO08682.1 - 0.0027 16.8 10.1 0.003 16.6 10.1 1.0 1 0 0 1 1 1 1 CLN3 protein DUF2370 PF10176.9 ETO08682.1 - 0.027 14.1 5.5 0.03 14.0 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SpoIIP PF07454.11 ETO08682.1 - 0.036 13.5 16.5 0.037 13.5 16.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CSRNP_N PF16019.5 ETO08682.1 - 0.052 13.5 12.9 0.062 13.2 12.9 1.0 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Vfa1 PF08432.10 ETO08682.1 - 0.063 13.6 26.4 0.077 13.3 26.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Spore_coat_CotO PF14153.6 ETO08682.1 - 0.063 13.2 19.9 0.067 13.1 19.9 1.0 1 0 0 1 1 1 0 Spore coat protein CotO DUF2052 PF09747.9 ETO08682.1 - 0.079 13.1 19.1 0.092 12.9 19.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CobT PF06213.12 ETO08682.1 - 0.12 11.8 12.7 0.13 11.7 12.7 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 ETO08682.1 - 0.13 12.4 13.4 0.17 12.1 13.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NPR3 PF03666.13 ETO08682.1 - 0.14 11.0 19.2 0.15 10.8 19.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Gti1_Pac2 PF09729.9 ETO08682.1 - 0.14 12.2 16.7 0.17 12.0 16.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.22 ETO08682.1 - 0.16 11.1 10.4 0.18 11.0 10.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4746 PF15928.5 ETO08682.1 - 0.18 11.2 14.4 0.21 11.0 14.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 ETO08682.1 - 0.19 10.5 16.1 0.2 10.4 16.1 1.0 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 ETO08682.1 - 0.19 11.3 14.5 0.23 11.1 14.5 1.1 1 0 0 1 1 1 0 Spt20 family DAG_kinase_N PF14513.6 ETO08682.1 - 0.2 11.8 16.8 0.26 11.5 16.8 1.0 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Slu7 PF11708.8 ETO08682.1 - 0.21 11.3 25.9 0.27 11.0 25.9 1.0 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor RNA_pol_Rpc4 PF05132.14 ETO08682.1 - 0.24 11.8 16.4 0.31 11.5 16.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 UPF0565 PF10561.9 ETO08682.1 - 0.27 10.4 8.0 0.3 10.2 8.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 SLC12 PF03522.15 ETO08682.1 - 0.37 9.7 17.2 0.42 9.6 17.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO08682.1 - 0.39 9.0 19.6 0.44 8.8 19.6 1.0 1 0 0 1 1 1 0 CDC45-like protein HSP90 PF00183.18 ETO08682.1 - 0.42 9.5 22.8 0.49 9.2 22.8 1.0 1 0 0 1 1 1 0 Hsp90 protein OATP PF03137.20 ETO08682.1 - 0.52 8.5 9.7 0.72 8.1 9.7 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2151 PF10221.9 ETO08682.1 - 0.6 8.6 15.6 0.66 8.5 15.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DDHD PF02862.17 ETO08682.1 - 0.66 10.1 11.0 0.77 9.9 11.0 1.1 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 ETO08682.1 - 0.71 8.8 9.4 0.69 8.8 9.4 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 ETO08682.1 - 0.8 9.5 26.5 0.94 9.2 26.5 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 ETO08682.1 - 0.87 7.6 11.8 0.98 7.5 11.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4228 PF14009.6 ETO08682.1 - 0.88 9.9 11.3 1.1 9.6 11.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Kei1 PF08552.11 ETO08682.1 - 0.98 9.3 4.9 1.1 9.0 4.9 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4569 PF15133.6 ETO08682.1 - 1 9.0 16.0 1.2 8.7 16.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) DUF4551 PF15087.6 ETO08682.1 - 1 8.1 15.4 1.1 8.0 15.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Mem_trans PF03547.18 ETO08682.1 - 1.1 7.6 5.2 1.2 7.4 5.2 1.0 1 0 0 1 1 1 0 Membrane transport protein Afi1 PF07792.12 ETO08682.1 - 1.1 9.7 15.1 1.7 9.1 15.1 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ASC PF00858.24 ETO08682.1 - 1.1 8.1 13.6 1.2 8.0 13.6 1.0 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel DUF2126 PF09899.9 ETO08682.1 - 1.1 7.2 7.3 1.2 7.1 7.3 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) DUF853 PF05872.12 ETO08682.1 - 1.2 7.6 7.5 1.3 7.5 7.5 1.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) Sec62 PF03839.16 ETO08682.1 - 1.2 8.6 26.5 1.5 8.3 26.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Menin PF05053.13 ETO08682.1 - 1.3 7.3 9.8 1.4 7.2 9.8 1.0 1 0 0 1 1 1 0 Menin PPL5 PF18168.1 ETO08682.1 - 1.3 8.2 15.6 1.5 8.0 15.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 FHIPEP PF00771.20 ETO08682.1 - 1.6 7.1 6.2 2 6.8 6.2 1.2 1 0 0 1 1 1 0 FHIPEP family DUF3807 PF12720.7 ETO08682.1 - 1.7 8.9 27.2 2.2 8.5 27.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Membralin PF09746.9 ETO08682.1 - 1.9 7.4 11.0 2.1 7.3 11.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein Tmp39 PF10271.9 ETO08682.1 - 2.2 7.2 4.0 2.5 7.0 4.0 1.0 1 0 0 1 1 1 0 Putative transmembrane protein MMU163 PF17119.5 ETO08682.1 - 2.3 7.3 9.5 2.8 7.0 9.5 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DUF789 PF05623.12 ETO08682.1 - 2.4 7.8 11.4 2.6 7.6 11.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) YABBY PF04690.13 ETO08682.1 - 2.4 8.7 14.0 3 8.4 14.0 1.1 1 0 0 1 1 1 0 YABBY protein NARP1 PF12569.8 ETO08682.1 - 2.5 6.9 28.9 2.7 6.8 28.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Ctr PF04145.15 ETO08682.1 - 2.6 8.6 6.8 3.7 8.2 6.8 1.3 1 0 0 1 1 1 0 Ctr copper transporter family DUF4637 PF15470.6 ETO08682.1 - 2.7 7.7 14.3 3.8 7.2 14.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Rtf2 PF04641.12 ETO08682.1 - 2.8 7.3 28.0 3.4 7.0 28.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Paramyxo_ncap PF00973.19 ETO08682.1 - 2.9 6.7 11.8 3.2 6.6 11.8 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein AAA_11 PF13086.6 ETO08682.1 - 3.1 7.5 19.5 3.4 7.4 19.5 1.0 1 0 0 1 1 1 0 AAA domain SID-1_RNA_chan PF13965.6 ETO08682.1 - 3.5 5.9 10.6 3.8 5.8 10.6 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 ETO08682.1 - 3.6 5.4 20.1 4.2 5.1 20.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CSG2 PF16965.5 ETO08682.1 - 3.8 6.4 11.0 4.5 6.1 11.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Pannexin_like PF12534.8 ETO08682.1 - 3.8 6.5 14.1 4 6.4 14.1 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Neur_chan_memb PF02932.16 ETO08682.1 - 3.9 7.5 12.8 4.5 7.3 12.8 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RPN2_C PF18004.1 ETO08682.1 - 3.9 7.4 32.5 6 6.8 32.5 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF5308 PF17233.2 ETO08682.1 - 4.3 7.5 7.2 5.4 7.2 7.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) YqfQ PF14181.6 ETO08682.1 - 5.1 7.3 19.0 6.2 7.0 19.0 1.2 1 0 0 1 1 1 0 YqfQ-like protein LicD PF04991.13 ETO08682.1 - 5.5 7.1 19.4 6.3 6.9 19.4 1.1 1 0 0 1 1 1 0 LicD family Band_3_cyto PF07565.13 ETO08682.1 - 5.6 6.7 12.8 6.4 6.5 12.8 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain POX PF07526.11 ETO08682.1 - 5.9 7.5 16.6 7.1 7.2 16.6 1.1 1 0 0 1 1 1 0 Associated with HOX DUF4614 PF15391.6 ETO08682.1 - 6 6.8 12.7 7.4 6.5 12.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Serinc PF03348.15 ETO08682.1 - 6.6 5.5 10.4 7.8 5.3 10.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Sugar_tr PF00083.24 ETO08682.1 - 7.7 5.2 9.0 9.5 5.0 9.0 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter MCM_bind PF09739.9 ETO08682.1 - 8.3 4.7 19.7 9.5 4.5 19.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor ALMT PF11744.8 ETO08682.1 - 9.4 4.9 17.0 11 4.7 17.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter zf-C4H2 PF10146.9 ETO08684.1 - 0.0023 18.3 0.5 0.0027 18.0 0.5 1.0 1 0 0 1 1 1 1 Zinc finger-containing protein DUF3848 PF12959.7 ETO08684.1 - 0.013 15.5 1.4 0.077 13.1 1.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3848) Phg_2220_C PF09524.10 ETO08684.1 - 0.023 14.7 0.4 0.067 13.3 0.1 1.9 1 1 1 2 2 2 0 Conserved phage C-terminus (Phg_2220_C) DSHCT PF08148.12 ETO08684.1 - 0.027 14.2 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 DSHCT (NUC185) domain DUF5347 PF17282.2 ETO08684.1 - 0.042 14.2 0.2 0.099 13.0 0.2 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5347) WD40 PF00400.32 ETO08685.1 - 1.1e-41 140.0 14.2 3.9e-11 43.3 0.1 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08685.1 - 2.7e-18 66.1 0.2 0.0083 16.4 0.1 6.0 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO08685.1 - 4.6e-12 46.2 0.9 3.6e-05 23.7 0.1 3.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO08685.1 - 8.9e-09 34.3 0.1 0.00066 18.3 0.0 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO08685.1 - 4.6e-07 28.9 2.3 0.06 12.0 0.0 4.1 1 1 4 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO08685.1 - 8.2e-07 28.8 9.1 0.12 12.3 0.0 6.8 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO08685.1 - 8.6e-07 28.2 0.7 0.01 14.8 0.0 4.7 1 1 2 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Coatomer_WDAD PF04053.14 ETO08685.1 - 8e-06 25.2 2.3 0.00012 21.3 0.8 2.2 1 1 1 2 2 2 1 Coatomer WD associated region DUF1797 PF08796.10 ETO08685.1 - 2.8e-05 24.1 0.0 6.5 6.9 0.0 4.4 3 1 1 4 4 4 1 Protein of unknown function (DUF1797) Nbas_N PF15492.6 ETO08685.1 - 0.00076 18.9 1.0 3.1 7.1 0.0 3.7 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO08685.1 - 0.018 13.8 8.0 11 4.7 0.1 4.3 1 1 0 2 2 2 0 Nup133 N terminal like WD40_like PF17005.5 ETO08685.1 - 0.019 14.3 2.0 0.99 8.7 0.3 3.3 2 1 0 3 3 3 0 WD40-like domain Gmad1 PF10647.9 ETO08685.1 - 0.035 13.9 0.0 0.27 10.9 0.0 2.4 2 1 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain DUF2963 PF11178.8 ETO08685.1 - 0.038 13.7 0.6 2.8 7.7 0.1 3.6 3 1 0 3 3 3 0 Protein of unknown function (DUF2963) DUF5122 PF17164.4 ETO08685.1 - 0.076 13.3 0.0 18 5.7 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Proteasome_A_N PF10584.9 ETO08685.1 - 0.67 9.7 9.6 22 4.8 0.0 4.9 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature F5_F8_type_C PF00754.25 ETO08686.1 - 0.00043 20.4 0.2 0.0016 18.6 0.0 1.9 2 0 0 2 2 2 1 F5/8 type C domain GWT1 PF06423.12 ETO08686.1 - 0.24 11.5 5.2 0.76 9.9 0.1 2.4 2 0 0 2 2 2 0 GWT1 NOT2_3_5 PF04153.18 ETO08687.1 - 1.3e-05 25.3 0.4 1.3e-05 25.3 0.4 2.7 2 1 0 2 2 2 1 NOT2 / NOT3 / NOT5 family TPR_1 PF00515.28 ETO08689.1 - 5.2e-10 38.7 5.3 0.0014 18.4 0.5 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO08689.1 - 7.2e-09 35.1 5.1 0.0022 18.0 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat FKBP_C PF00254.28 ETO08689.1 - 1.2e-06 28.7 0.0 2.5e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_9 PF13371.6 ETO08689.1 - 2.3e-06 27.7 0.2 4e-06 26.9 0.2 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO08689.1 - 4e-06 27.2 1.6 0.0002 21.8 1.1 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO08689.1 - 5.2e-05 23.8 1.7 0.00066 20.3 0.4 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO08689.1 - 0.0043 17.8 0.7 0.11 13.3 0.1 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO08689.1 - 0.0085 16.4 2.4 0.41 11.0 0.0 3.1 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO08689.1 - 0.0095 16.1 4.2 0.15 12.3 0.5 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETO08689.1 - 0.035 14.3 4.6 0.12 12.6 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TAN PF11640.8 ETO08689.1 - 0.047 13.8 0.4 0.047 13.8 0.4 1.5 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair TPR_11 PF13414.6 ETO08689.1 - 0.083 12.6 3.8 0.64 9.7 0.3 2.5 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.6 ETO08689.1 - 1.4 9.8 5.5 66 4.5 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat DUF2715 PF10895.8 ETO08691.1 - 0.065 12.9 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2715) PseudoU_synth_2 PF00849.22 ETO08692.1 - 1.1e-10 41.9 0.0 2.5e-10 40.7 0.0 1.6 1 1 0 1 1 1 1 RNA pseudouridylate synthase Myb_DNA-binding PF00249.31 ETO08696.1 - 2.3 8.5 6.0 1.3 9.3 0.7 3.2 3 1 0 3 3 3 0 Myb-like DNA-binding domain RCC1 PF00415.18 ETO08698.1 - 1.5e-09 38.3 0.3 1e-08 35.7 0.0 2.6 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO08698.1 - 1.9e-09 37.1 5.1 0.00039 20.1 0.7 3.8 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Hira PF07569.11 ETO08698.1 - 0.038 13.7 0.1 9.2 5.9 0.0 2.4 2 0 0 2 2 2 0 TUP1-like enhancer of split NERD PF08378.11 ETO08698.1 - 0.074 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Nuclease-related domain Exo_endo_phos_2 PF14529.6 ETO08699.1 - 1.2e-07 31.5 2.3 1.2e-07 31.5 2.3 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase PSI_integrin PF17205.3 ETO08699.1 - 0.61 9.9 12.6 0.5 10.1 3.7 2.7 1 1 1 2 2 2 0 Integrin plexin domain Kelch_6 PF13964.6 ETO08701.1 - 0.017 15.4 0.3 0.12 12.7 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO08701.1 - 0.056 13.0 3.2 0.62 9.7 0.0 3.4 4 0 0 4 4 4 0 Kelch motif DUF3807 PF12720.7 ETO08704.1 - 0.49 10.6 10.2 4.2 7.6 10.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) ICAT PF06384.11 ETO08704.1 - 0.58 10.4 0.1 0.58 10.4 0.1 2.5 3 0 0 3 3 3 0 Beta-catenin-interacting protein ICAT Presenilin PF01080.17 ETO08704.1 - 1 8.0 5.2 1.2 7.8 5.2 1.1 1 0 0 1 1 1 0 Presenilin EVI2A PF05399.11 ETO08705.1 - 0.0068 16.0 0.3 0.0099 15.5 0.3 1.2 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) WD40 PF00400.32 ETO08706.1 - 4.9e-60 198.1 18.6 1.5e-10 41.5 0.4 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08706.1 - 1.1e-19 70.5 3.0 0.0028 17.9 0.1 7.2 2 1 6 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08706.1 - 5.3e-16 58.5 0.9 0.0053 15.8 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO08706.1 - 4.5e-07 29.5 2.2 0.0011 18.4 0.4 4.0 1 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO08706.1 - 5.2e-07 28.7 5.8 0.17 10.5 0.2 5.0 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO08706.1 - 8.3e-07 27.9 0.7 0.0084 14.7 0.0 2.9 2 1 0 3 3 3 2 Cytochrome D1 heme domain BBS2_Mid PF14783.6 ETO08706.1 - 0.0035 17.4 1.4 1.3 9.1 0.0 4.4 3 1 2 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 ETO08706.1 - 0.0055 15.5 9.9 1 8.0 0.1 3.8 1 1 3 4 4 4 4 Nup133 N terminal like PD40 PF07676.12 ETO08706.1 - 0.0063 16.4 6.9 7.5 6.6 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF1854 PF08909.11 ETO08706.1 - 0.29 11.0 1.6 3.3 7.5 0.1 2.9 1 1 1 3 3 3 0 Domain of unknown function (DUF1854) NDUF_B8 PF05821.11 ETO08707.1 - 0.061 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) IBV_3C PF03620.13 ETO08708.1 - 0.99 9.9 3.2 3.7 8.1 0.1 2.3 1 1 1 2 2 2 0 IBV 3C protein MFS_1 PF07690.16 ETO08711.1 - 2.1e-31 109.1 15.8 2.6e-31 108.8 15.8 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF21 PF01595.20 ETO08711.1 - 0.046 13.4 2.8 0.63 9.7 0.8 2.9 2 1 1 3 3 3 0 Cyclin M transmembrane N-terminal domain DLIC PF05783.11 ETO08712.1 - 6.5e-06 25.2 2.2 0.0036 16.2 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) Roc PF08477.13 ETO08712.1 - 0.017 15.4 1.4 1.2 9.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ETO08712.1 - 0.027 13.8 0.0 0.049 13.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family FeoB_N PF02421.18 ETO08712.1 - 0.1 12.1 0.3 0.29 10.7 0.0 1.9 3 0 0 3 3 3 0 Ferrous iron transport protein B Cytochrom_B_C PF00032.17 ETO08712.1 - 0.23 11.8 5.1 0.22 11.8 2.9 1.9 2 0 0 2 2 2 0 Cytochrome b(C-terminal)/b6/petD Dna2 PF08696.11 ETO08714.1 - 9.3e-11 41.9 0.2 2.4e-10 40.5 0.2 1.7 1 1 0 1 1 1 1 DNA replication factor Dna2 MG4 PF17789.1 ETO08714.1 - 0.0061 16.7 1.0 0.011 15.9 0.2 1.8 2 0 0 2 2 2 1 Macroglobulin domain MG4 WD40 PF00400.32 ETO08715.1 - 5.3e-15 55.6 13.4 1.6e-07 31.9 0.9 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO08715.1 - 1.2e-06 27.5 0.4 0.0098 14.6 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08715.1 - 0.00098 18.5 0.9 0.0026 17.1 0.8 1.6 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO08715.1 - 0.0018 18.5 0.1 0.021 15.1 0.0 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO08715.1 - 0.11 12.0 6.0 0.35 10.4 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) AAA PF00004.29 ETO08717.1 - 0.017 15.5 0.0 0.023 15.1 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) O_anti_polymase PF01901.16 ETO08718.1 - 0.014 14.7 2.2 0.014 14.7 0.9 1.6 2 0 0 2 2 2 0 Putative O-antigen polymerase Churchill PF06573.11 ETO08718.1 - 0.11 12.8 0.1 0.11 12.8 0.1 1.8 2 0 0 2 2 2 0 Churchill protein DUF1041 PF06292.17 ETO08718.1 - 0.3 11.5 3.8 0.67 10.4 0.1 2.8 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1041) Ctr PF04145.15 ETO08718.1 - 0.79 10.3 4.3 4.6 7.9 0.8 2.4 1 1 1 2 2 2 0 Ctr copper transporter family BHD_2 PF10404.9 ETO08718.1 - 4 8.5 7.0 0.51 11.3 2.0 2.3 2 1 0 2 2 2 0 Rad4 beta-hairpin domain 2 ETRAMP PF09716.10 ETO08720.1 - 0.0053 16.8 5.2 0.0053 16.8 5.2 2.5 2 1 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) PigN PF04987.14 ETO08720.1 - 0.021 13.7 0.2 0.023 13.6 0.2 1.2 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) PP_kinase_N PF13089.6 ETO08720.1 - 0.69 10.3 5.6 0.17 12.2 1.9 1.7 1 1 1 2 2 2 0 Polyphosphate kinase N-terminal domain Ribosomal_S5 PF00333.20 ETO08721.1 - 3.5e-09 36.5 0.3 5.7e-09 35.8 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ETO08721.1 - 0.00013 21.3 0.0 0.00022 20.6 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain DUF3283 PF11686.8 ETO08721.1 - 0.13 12.1 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3283) NACHT PF05729.12 ETO08722.1 - 2.2e-05 24.4 0.0 3.6e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 NACHT domain Uteroglobin PF01099.17 ETO08722.1 - 0.12 12.8 1.4 0.27 11.6 1.4 1.5 1 0 0 1 1 1 0 Uteroglobin family LMBR1 PF04791.16 ETO08724.1 - 0.0024 16.9 6.7 0.0024 16.9 6.7 3.1 3 0 0 3 3 3 1 LMBR1-like membrane protein DDHD PF02862.17 ETO08725.1 - 0.00081 19.6 7.5 0.0011 19.2 7.5 1.2 1 0 0 1 1 1 1 DDHD domain Macoilin PF09726.9 ETO08725.1 - 0.0034 16.0 11.4 0.004 15.8 11.4 1.2 1 0 0 1 1 1 1 Macoilin family SOBP PF15279.6 ETO08725.1 - 0.95 10.0 10.4 1.2 9.7 10.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4551 PF15087.6 ETO08725.1 - 1.3 7.7 12.1 1.6 7.5 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TP53IP5 PF15331.6 ETO08725.1 - 1.9 8.6 19.8 2.5 8.2 19.8 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4662 PF15578.6 ETO08725.1 - 2.3 7.9 17.3 3 7.6 17.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) CDC27 PF09507.10 ETO08725.1 - 4.9 6.4 32.9 5.8 6.2 32.9 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Transformer PF06495.11 ETO08725.1 - 4.9 7.2 14.7 7.4 6.6 14.7 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein BROMI PF14961.6 ETO08725.1 - 5 4.4 10.9 5.9 4.2 10.9 1.0 1 0 0 1 1 1 0 Broad-minded protein Neur_chan_memb PF02932.16 ETO08725.1 - 5.2 7.0 13.7 8.9 6.3 13.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region AF-4 PF05110.13 ETO08725.1 - 5.6 4.9 28.9 6.8 4.6 28.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein CDC45 PF02724.14 ETO08725.1 - 5.7 5.1 28.0 6.8 4.9 28.0 1.2 1 0 0 1 1 1 0 CDC45-like protein ANAPC8 PF04049.13 ETO08727.1 - 5.2e-07 29.8 0.2 0.0002 21.4 0.0 2.9 2 1 0 2 2 2 1 Anaphase promoting complex subunit 8 / Cdc23 TPR_2 PF07719.17 ETO08727.1 - 9.6e-05 22.2 16.8 0.00084 19.3 0.4 5.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO08727.1 - 0.00058 19.9 4.8 0.075 13.3 0.1 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO08727.1 - 0.0014 19.2 2.6 0.22 12.4 0.1 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO08727.1 - 0.0018 18.4 22.9 0.064 13.5 6.9 5.4 4 3 1 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO08727.1 - 0.0021 18.5 0.3 0.15 12.6 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO08727.1 - 0.0024 18.1 3.9 0.6 10.4 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO08727.1 - 0.0033 17.2 0.2 0.0033 17.2 0.2 4.3 5 0 0 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 ETO08727.1 - 0.011 15.7 0.1 0.49 10.5 0.0 2.6 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO08727.1 - 0.022 14.4 5.2 0.099 12.4 0.1 3.1 3 0 0 3 3 3 0 TPR repeat TPR_7 PF13176.6 ETO08727.1 - 0.022 14.7 2.0 0.46 10.6 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO08727.1 - 0.027 14.9 5.5 0.23 11.9 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO08727.1 - 0.13 12.9 4.8 1.9 9.3 0.2 4.3 4 0 0 4 4 4 0 Sel1 repeat DUF92 PF01940.16 ETO08727.1 - 0.23 10.9 0.2 0.35 10.3 0.2 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 TPR_6 PF13174.6 ETO08727.1 - 0.25 12.1 1.8 42 5.1 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO08727.1 - 1.7 8.7 6.9 0.37 10.7 0.4 3.2 5 0 0 5 5 4 0 Tetratricopeptide repeat Scs3p PF10261.9 ETO08728.1 - 0.21 11.1 1.2 0.21 11.0 1.2 1.0 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Connexin PF00029.19 ETO08728.1 - 0.37 10.5 11.0 0.38 10.5 11.0 1.0 1 0 0 1 1 1 0 Connexin Afi1 PF07792.12 ETO08728.1 - 0.81 10.2 6.1 0.92 10.0 6.1 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Sec62 PF03839.16 ETO08728.1 - 9 5.7 16.8 10 5.6 16.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PCM1_C PF15717.5 ETO08728.1 - 9.4 4.8 11.5 10 4.7 11.5 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus Kelch_6 PF13964.6 ETO08729.1 - 0.029 14.7 0.6 0.5 10.7 0.0 2.7 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO08729.1 - 0.078 12.6 0.1 1.2 8.8 0.0 2.5 2 0 0 2 2 2 0 Kelch motif YL1 PF05764.13 ETO08730.1 - 3.6 7.6 44.0 1.5 8.9 22.5 2.1 1 1 1 2 2 2 0 YL1 nuclear protein BAAT_C PF08840.11 ETO08730.1 - 7.8 6.3 7.5 0.18 11.7 0.8 1.7 2 0 0 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF3611 PF12263.8 ETO08731.1 - 0.097 12.6 0.1 0.14 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) CagS PF16707.5 ETO08732.1 - 0.0091 16.0 0.2 0.019 15.0 0.2 1.5 1 0 0 1 1 1 1 Cag pathogenicity island protein S of Helicobacter pylori EF-hand_1 PF00036.32 ETO08733.1 - 0.0005 19.4 0.2 0.0012 18.2 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO08733.1 - 0.00091 19.0 0.0 0.0021 17.8 0.0 1.6 1 0 0 1 1 1 1 EF-hand domain IMUP PF15761.5 ETO08733.1 - 0.0018 19.0 2.6 0.0034 18.1 2.6 1.5 1 0 0 1 1 1 1 Immortalisation up-regulated protein EF-hand_7 PF13499.6 ETO08733.1 - 0.0086 16.5 0.1 0.018 15.4 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.6 ETO08733.1 - 0.039 13.8 0.0 0.12 12.3 0.0 1.9 1 0 0 1 1 1 0 EF hand Lge1 PF11488.8 ETO08733.1 - 0.064 13.4 0.3 0.74 10.0 0.1 2.4 2 0 0 2 2 2 0 Transcriptional regulatory protein LGE1 DUF5423 PF17461.2 ETO08733.1 - 0.12 11.2 4.0 0.2 10.5 4.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5423) DUF4665 PF15679.5 ETO08733.1 - 6.6 7.4 8.0 0.42 11.3 0.3 2.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4665) FCH PF00611.23 ETO08734.1 - 0.021 15.1 1.1 0.042 14.1 1.1 1.5 1 0 0 1 1 1 0 Fes/CIP4, and EFC/F-BAR homology domain CRR7 PF12095.8 ETO08734.1 - 0.063 13.7 2.0 0.079 13.4 1.0 1.7 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 MutS_IV PF05190.18 ETO08736.1 - 0.0085 16.4 1.4 0.018 15.4 0.4 2.1 2 0 0 2 2 2 1 MutS family domain IV Sulfatase_C PF14707.6 ETO08736.1 - 0.26 12.0 0.1 0.26 12.0 0.1 2.2 3 1 0 3 3 3 0 C-terminal region of aryl-sulfatase Tctex-1 PF03645.13 ETO08736.1 - 0.53 10.5 4.2 5.6 7.3 2.4 2.4 2 1 0 2 2 2 0 Tctex-1 family WD40 PF00400.32 ETO08737.1 - 1.3e-17 63.8 8.8 2.7e-05 24.9 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO08737.1 - 0.0002 20.2 0.2 0.2 10.3 0.1 2.9 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO08737.1 - 0.0018 18.6 0.7 13 6.2 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain GPHH PF16905.5 ETO08740.1 - 2.5e-16 59.2 0.0 4.2e-16 58.5 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated WD40 PF00400.32 ETO08742.1 - 2.4e-27 94.6 34.0 2.5e-06 28.1 0.5 7.8 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08742.1 - 1.5e-08 34.8 1.5 0.99 9.7 0.0 5.9 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2730 PF10805.8 ETO08742.1 - 0.067 13.3 7.0 0.2 11.7 7.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) OmpH PF03938.14 ETO08742.1 - 5.3 7.4 28.9 3.4 8.0 18.0 2.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3989 PF13150.6 ETO08744.1 - 0.084 12.6 0.0 0.18 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3989) FAM183 PF14886.6 ETO08744.1 - 1.3 9.8 9.4 0.56 11.0 7.1 1.5 2 0 0 2 2 2 0 FAM183A and FAM183B related APG6_N PF17675.1 ETO08745.1 - 4.2 7.9 78.4 9.2 6.8 28.5 4.0 1 1 2 3 3 3 0 Apg6 coiled-coil region Stc1 PF12898.7 ETO08746.1 - 0.13 12.9 1.7 0.26 11.8 1.7 1.5 1 0 0 1 1 1 0 Stc1 domain Lant_dehydr_C PF14028.6 ETO08748.1 - 0.039 13.5 1.7 10 5.5 0.1 3.4 3 0 0 3 3 3 0 Lantibiotic biosynthesis dehydratase C-term WD40 PF00400.32 ETO08749.1 - 2.8e-33 113.4 6.7 2.5e-08 34.4 0.3 6.2 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08749.1 - 1.1e-17 64.1 3.1 0.0017 18.6 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08749.1 - 2.5e-10 40.2 12.7 0.00015 21.2 1.3 3.1 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO08749.1 - 2.3e-05 23.3 1.8 0.24 10.0 0.1 3.7 1 1 3 4 4 4 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO08749.1 - 0.00035 20.4 0.0 1.2 9.2 0.0 4.5 4 0 0 4 4 4 1 PQQ enzyme repeat BBS2_Mid PF14783.6 ETO08749.1 - 0.0014 18.7 7.3 3.8 7.6 0.1 4.1 1 1 3 4 4 4 3 Ciliary BBSome complex subunit 2, middle region HARP PF07443.13 ETO08749.1 - 0.0042 16.7 0.5 2.3 7.9 0.1 3.0 3 0 0 3 3 3 2 HepA-related protein (HARP) PD40 PF07676.12 ETO08749.1 - 0.03 14.3 0.9 28 4.8 0.0 3.6 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat SoxZ PF08770.11 ETO08749.1 - 0.18 11.6 0.6 5.2 6.9 0.0 3.1 4 0 0 4 4 4 0 Sulphur oxidation protein SoxZ Kelch_1 PF01344.25 ETO08750.1 - 5.6e-07 29.0 3.5 8.8e-05 22.0 0.2 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO08750.1 - 2.7e-06 27.5 4.8 0.29 11.5 0.0 4.6 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO08750.1 - 0.0011 18.9 2.2 0.48 10.5 0.4 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO08750.1 - 0.014 15.3 6.7 1.4 9.0 0.7 4.9 6 0 0 6 6 6 0 Kelch motif Kelch_4 PF13418.6 ETO08750.1 - 0.032 14.2 0.5 0.15 12.1 0.2 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain RhoGAP-FF1 PF16512.5 ETO08750.1 - 0.067 13.9 1.9 0.098 13.4 0.1 2.2 3 0 0 3 3 3 0 p190-A and -B Rho GAPs FF domain DUF2098 PF09871.9 ETO08751.1 - 0.087 13.2 0.8 0.28 11.6 0.2 2.2 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) DUF5100 PF17029.5 ETO08751.1 - 0.56 10.1 7.9 0.26 11.1 0.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5100) FXMRP1_C_core PF12235.8 ETO08752.1 - 0.36 11.5 7.4 0.15 12.7 2.9 2.1 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal FoP_duplication PF13865.6 ETO08752.1 - 8 7.1 18.2 8.3 7.0 2.2 2.2 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 PKD_channel PF08016.12 ETO08753.1 - 1.3e-12 47.2 10.3 1.3e-12 47.2 10.3 2.1 2 1 0 2 2 2 1 Polycystin cation channel EF-hand_1 PF00036.32 ETO08753.1 - 2.5e-09 36.0 1.7 8.1e-05 21.9 0.3 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO08753.1 - 7.5e-08 31.7 1.2 0.0033 17.2 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO08753.1 - 3.2e-06 26.4 1.4 0.064 12.8 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO08753.1 - 0.00057 20.3 3.4 0.002 18.5 1.7 2.6 1 1 2 3 3 3 3 EF-hand domain pair Ion_trans PF00520.31 ETO08753.1 - 0.0015 17.8 13.6 0.0015 17.8 13.6 2.2 2 0 0 2 2 2 1 Ion transport protein SPARC_Ca_bdg PF10591.9 ETO08753.1 - 0.0035 17.6 0.3 0.0035 17.6 0.3 2.4 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF2431 PF10354.9 ETO08753.1 - 0.045 14.0 0.0 0.77 10.0 0.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF2431) EF-hand_8 PF13833.6 ETO08753.1 - 0.82 9.6 4.7 0.56 10.1 0.7 2.6 2 1 1 3 3 3 0 EF-hand domain pair DUF1007 PF06226.13 ETO08753.1 - 2.6 8.0 6.7 6.7 6.6 2.7 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1007) WD40 PF00400.32 ETO08754.1 - 1.4e-07 32.1 12.6 0.012 16.4 2.7 4.6 3 2 0 3 3 3 3 WD domain, G-beta repeat zf-CCHC PF00098.23 ETO08755.1 - 0.058 13.5 13.4 0.4 10.8 3.8 2.7 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 ETO08755.1 - 3.6 7.4 8.8 0.94 9.3 1.0 2.6 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 ETO08756.1 - 6.9e-46 156.5 0.1 1.9e-45 155.1 0.1 1.8 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 ETO08756.1 - 1.6e-17 63.4 0.3 5.9e-17 61.6 0.3 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 ETO08756.1 - 3.3e-17 63.0 0.0 1.2e-16 61.1 0.0 2.0 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 ETO08756.1 - 0.00022 21.9 0.3 0.00022 21.9 0.3 3.1 3 0 0 3 3 3 1 zinc-binding in reverse transcriptase NACHT PF05729.12 ETO08757.1 - 1.2e-09 38.3 0.1 7.5e-09 35.7 0.1 1.9 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO08757.1 - 0.0012 18.1 0.0 0.0018 17.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_16 PF13191.6 ETO08757.1 - 0.0016 18.8 0.0 0.003 18.0 0.0 1.4 2 0 0 2 2 2 1 AAA ATPase domain DAP3 PF10236.9 ETO08757.1 - 0.0054 16.0 0.0 0.0082 15.3 0.0 1.3 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 SMC_N PF02463.19 ETO08757.1 - 0.007 15.8 0.0 0.0084 15.6 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ETO08757.1 - 0.011 16.0 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ETO08757.1 - 0.013 14.7 0.4 0.028 13.6 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Torsin PF06309.11 ETO08757.1 - 0.073 13.2 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Torsin CoaE PF01121.20 ETO08757.1 - 0.12 12.1 0.0 11 5.6 0.0 2.2 2 0 0 2 2 2 0 Dephospho-CoA kinase RsgA_GTPase PF03193.16 ETO08757.1 - 0.15 12.0 0.0 0.21 11.5 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase Kelch_1 PF01344.25 ETO08759.1 - 6.9e-10 38.4 1.2 3.4e-05 23.3 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO08759.1 - 4.4e-06 26.4 2.6 0.015 15.2 0.3 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO08759.1 - 2.3e-05 24.5 0.2 0.12 12.7 0.0 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO08759.1 - 0.00034 20.5 0.9 0.11 12.6 0.2 3.4 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08759.1 - 0.00044 20.2 6.2 0.62 10.1 0.3 4.0 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO08759.1 - 0.0018 18.5 6.9 0.18 12.1 0.5 4.3 3 1 1 4 4 4 2 Kelch motif DNA_pol3_delta PF06144.13 ETO08759.1 - 0.035 13.9 0.0 0.074 12.8 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit YppG PF14179.6 ETO08760.1 - 0.027 15.2 3.6 0.061 14.0 3.6 1.5 1 0 0 1 1 1 0 YppG-like protein Trypan_PARP PF05887.11 ETO08760.1 - 0.032 14.2 1.4 0.054 13.5 1.4 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SARAF PF06682.12 ETO08760.1 - 0.052 13.2 0.4 0.1 12.2 0.0 1.8 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis PRIMA1 PF16101.5 ETO08760.1 - 2 8.5 7.1 7 6.7 7.1 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 zf-C3HC4_3 PF13920.6 ETO08762.1 - 9.3e-11 41.4 10.8 1.7e-10 40.6 10.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO08762.1 - 7.9e-09 35.2 9.7 1.4e-08 34.4 9.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 MBT PF02820.18 ETO08762.1 - 0.0097 16.2 0.2 0.042 14.2 0.1 2.1 2 0 0 2 2 2 1 mbt repeat zf-RING_5 PF14634.6 ETO08762.1 - 0.022 14.7 11.7 0.053 13.5 11.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain SAM_1 PF00536.30 ETO08762.1 - 0.025 15.0 0.3 0.13 12.8 0.1 2.2 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) PHF5 PF03660.14 ETO08762.1 - 0.057 13.6 5.4 0.15 12.3 5.4 1.6 1 0 0 1 1 1 0 PHF5-like protein Phage_Gp23 PF10669.9 ETO08762.1 - 0.23 11.8 2.7 0.47 10.8 2.7 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) zf-RING_2 PF13639.6 ETO08762.1 - 0.24 11.8 12.0 0.6 10.5 12.0 1.7 1 0 0 1 1 1 0 Ring finger domain DUF3330 PF11809.8 ETO08762.1 - 8.6 6.5 9.4 0.85 9.7 4.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3330) zf-C3HC4_3 PF13920.6 ETO08763.1 - 1.7e-09 37.4 15.4 2.9e-09 36.6 15.4 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO08763.1 - 4.8e-05 23.1 13.7 9e-05 22.3 13.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 MBT PF02820.18 ETO08763.1 - 0.00051 20.3 0.4 0.98 9.8 0.0 3.1 3 0 0 3 3 3 2 mbt repeat SAM_1 PF00536.30 ETO08763.1 - 0.0014 19.1 0.9 0.0056 17.1 0.3 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SH3_2 PF07653.17 ETO08763.1 - 0.018 14.7 0.1 0.084 12.6 0.0 2.2 2 0 0 2 2 2 0 Variant SH3 domain zf-RING_5 PF14634.6 ETO08763.1 - 0.13 12.2 15.6 0.23 11.5 15.6 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Tudor-knot PF11717.8 ETO08763.1 - 0.13 12.2 1.4 2.9 7.8 0.3 3.0 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain zf-RING_2 PF13639.6 ETO08763.1 - 0.74 10.2 16.5 1.5 9.2 16.5 1.5 1 0 0 1 1 1 0 Ring finger domain ATP_bind_1 PF03029.17 ETO08764.1 - 2e-22 80.2 0.6 3.1e-22 79.5 0.1 1.5 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein Linker_histone PF00538.19 ETO08764.1 - 0.46 10.9 3.8 0.78 10.1 0.1 2.3 2 0 0 2 2 2 0 linker histone H1 and H5 family ATP_bind_1 PF03029.17 ETO08765.1 - 7.2e-41 140.5 0.0 9e-41 140.2 0.0 1.0 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 ETO08765.1 - 5.2e-05 23.7 0.0 5.9e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 ETO08765.1 - 6.8e-05 22.8 0.0 0.0001 22.2 0.0 1.2 1 0 0 1 1 1 1 NACHT domain SRP54 PF00448.22 ETO08765.1 - 0.00021 21.0 0.0 0.0073 16.0 0.0 2.2 2 0 0 2 2 2 1 SRP54-type protein, GTPase domain AAA_22 PF13401.6 ETO08765.1 - 0.00024 21.4 0.0 0.00031 21.0 0.0 1.2 1 0 0 1 1 1 1 AAA domain Arf PF00025.21 ETO08765.1 - 0.00028 20.4 0.0 0.00038 20.0 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 ETO08765.1 - 0.00029 20.6 0.0 0.0004 20.2 0.0 1.1 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO08765.1 - 0.00048 20.3 0.0 0.00082 19.5 0.0 1.4 1 1 0 1 1 1 1 AAA domain cobW PF02492.19 ETO08765.1 - 0.0006 19.4 0.0 0.08 12.5 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain AAA_18 PF13238.6 ETO08765.1 - 0.00088 19.8 0.0 0.0011 19.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETO08765.1 - 0.00095 18.7 0.0 0.0014 18.2 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region PduV-EutP PF10662.9 ETO08765.1 - 0.001 18.8 0.7 0.031 14.0 0.0 2.8 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 ETO08765.1 - 0.0012 18.1 0.0 0.0019 17.4 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain MMR_HSR1 PF01926.23 ETO08765.1 - 0.002 18.2 0.0 0.012 15.6 0.0 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_31 PF13614.6 ETO08765.1 - 0.0022 18.0 0.1 0.14 12.0 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO08765.1 - 0.0026 17.5 0.0 0.0034 17.1 0.0 1.1 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ETO08765.1 - 0.0038 16.5 0.0 0.0049 16.2 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin GTP_EFTU PF00009.27 ETO08765.1 - 0.0052 16.3 0.2 0.064 12.8 0.2 2.0 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ATPase_2 PF01637.18 ETO08765.1 - 0.0059 16.5 0.0 0.0074 16.2 0.0 1.1 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea NTPase_1 PF03266.15 ETO08765.1 - 0.011 15.7 0.0 0.54 10.2 0.0 2.2 2 0 0 2 2 2 0 NTPase PRK PF00485.18 ETO08765.1 - 0.017 14.8 0.0 0.021 14.6 0.0 1.3 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family AAA_14 PF13173.6 ETO08765.1 - 0.021 14.8 0.2 0.086 12.9 0.2 1.9 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 ETO08765.1 - 0.021 14.2 0.0 0.063 12.7 0.0 1.8 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit Viral_helicase1 PF01443.18 ETO08765.1 - 0.022 14.5 0.0 0.026 14.2 0.0 1.3 1 1 0 1 1 1 0 Viral (Superfamily 1) RNA helicase DLIC PF05783.11 ETO08765.1 - 0.033 13.0 0.0 0.047 12.5 0.0 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_29 PF13555.6 ETO08765.1 - 0.034 13.9 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain PhoH PF02562.16 ETO08765.1 - 0.042 13.3 0.0 0.053 13.0 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_19 PF13245.6 ETO08765.1 - 0.043 14.1 0.1 0.068 13.5 0.1 1.3 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 ETO08765.1 - 0.043 14.0 0.1 0.2 11.9 0.0 1.9 1 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO08765.1 - 0.044 13.7 0.0 0.11 12.4 0.0 1.6 2 0 0 2 2 2 0 RsgA GTPase APS_kinase PF01583.20 ETO08765.1 - 0.048 13.6 0.0 0.057 13.3 0.0 1.3 1 1 0 1 1 1 0 Adenylylsulphate kinase DUF2075 PF09848.9 ETO08765.1 - 0.049 12.9 0.0 0.057 12.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) G-alpha PF00503.20 ETO08765.1 - 0.049 12.8 0.1 0.074 12.2 0.1 1.5 1 1 0 1 1 1 0 G-protein alpha subunit MobB PF03205.14 ETO08765.1 - 0.05 13.5 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_5 PF07728.14 ETO08765.1 - 0.054 13.5 0.0 0.065 13.2 0.0 1.2 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) T2SSE PF00437.20 ETO08765.1 - 0.07 12.2 0.0 0.081 12.0 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein TsaE PF02367.17 ETO08765.1 - 0.073 13.1 0.0 0.1 12.6 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Armet PF10208.9 ETO08765.1 - 0.099 12.6 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding DUF87 PF01935.17 ETO08765.1 - 0.11 12.6 0.1 0.15 12.2 0.1 1.4 1 1 0 1 1 1 0 Helicase HerA, central domain ABC_tran PF00005.27 ETO08765.1 - 0.13 12.8 0.2 0.18 12.3 0.2 1.4 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 ETO08765.1 - 0.15 12.3 0.0 0.24 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain TRM PF02005.16 ETO08766.1 - 2.9e-66 224.2 0.1 3.6e-66 223.9 0.1 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF4895 PF16236.5 ETO08766.1 - 0.00071 19.4 1.3 0.0011 18.7 1.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4895) Met_10 PF02475.16 ETO08766.1 - 0.014 15.2 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 Met-10+ like-protein TelA PF05816.11 ETO08766.1 - 0.028 13.5 2.0 0.043 12.9 2.0 1.2 1 0 0 1 1 1 0 Toxic anion resistance protein (TelA) Spermine_synth PF01564.17 ETO08766.1 - 0.034 13.6 0.0 0.098 12.1 0.0 1.7 2 0 0 2 2 2 0 Spermine/spermidine synthase domain Cons_hypoth95 PF03602.15 ETO08766.1 - 0.046 13.4 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 Conserved hypothetical protein 95 WD40 PF00400.32 ETO08768.1 - 0.0018 19.0 5.8 0.06 14.2 0.9 3.8 4 1 1 5 5 5 2 WD domain, G-beta repeat RVP PF00077.20 ETO08769.1 - 0.0016 18.7 0.0 0.003 17.8 0.0 1.4 1 0 0 1 1 1 1 Retroviral aspartyl protease SFTA2 PF15210.6 ETO08769.1 - 0.035 14.0 0.0 0.094 12.7 0.0 1.7 1 0 0 1 1 1 0 Surfactant-associated protein 2 gag-asp_proteas PF13975.6 ETO08769.1 - 0.14 12.7 0.0 0.22 12.1 0.0 1.5 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease DUF2487 PF10673.9 ETO08770.1 - 0.027 14.5 5.5 2 8.4 0.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2487) HTH_19 PF12844.7 ETO08770.1 - 0.53 10.3 4.0 0.28 11.2 1.0 2.1 3 0 0 3 3 3 0 Helix-turn-helix domain Epimerase PF01370.21 ETO08772.1 - 1.2e-14 54.4 0.0 1.4e-14 54.2 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO08772.1 - 1.3e-13 50.6 0.1 1.5e-13 50.4 0.1 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETO08772.1 - 1.6e-10 41.2 0.0 2e-10 40.9 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ETO08772.1 - 2.5e-08 33.7 0.0 2.8e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ETO08772.1 - 3.7e-07 30.0 0.0 4.5e-07 29.7 0.0 1.3 1 1 0 1 1 1 1 NmrA-like family adh_short PF00106.25 ETO08772.1 - 0.00066 19.2 0.0 0.00089 18.8 0.0 1.4 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO08772.1 - 0.0072 16.2 0.0 0.011 15.7 0.0 1.2 1 0 0 1 1 1 1 KR domain NAD_binding_4 PF07993.12 ETO08772.1 - 0.0078 15.4 0.2 0.12 11.5 0.2 2.0 1 1 0 1 1 1 1 Male sterility protein Polysacc_synt_2 PF02719.15 ETO08772.1 - 0.008 15.4 0.0 0.0088 15.2 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Pkinase PF00069.25 ETO08774.1 - 6.4e-30 104.4 0.8 6.4e-30 104.4 0.8 2.4 3 0 0 3 3 3 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08774.1 - 1.6e-15 57.1 0.9 9.1e-15 54.6 0.2 2.3 2 0 0 2 2 2 1 Protein tyrosine kinase PX PF00787.24 ETO08774.1 - 1.4e-11 44.4 5.8 4e-10 39.7 5.8 2.8 1 1 0 1 1 1 1 PX domain Shisa PF13908.6 ETO08774.1 - 0.24 11.6 0.0 0.24 11.6 0.0 2.9 3 1 0 3 3 3 0 Wnt and FGF inhibitory regulator Pkinase PF00069.25 ETO08775.1 - 1.9e-35 122.6 0.0 3.2e-35 121.8 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08775.1 - 4.7e-18 65.4 0.0 6.8e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO08775.1 - 0.007 15.4 0.0 0.011 14.7 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_C PF00433.24 ETO08775.1 - 0.94 10.2 6.1 3.5 8.4 6.1 2.1 1 1 0 1 1 1 0 Protein kinase C terminal domain Glyco_hydro_20 PF00728.22 ETO08778.1 - 8.9e-25 87.8 8.7 4.2e-24 85.6 8.7 1.8 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glyco_hydro_20 PF00728.22 ETO08779.1 - 1.3e-46 159.6 0.0 1.8e-46 159.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ETO08779.1 - 6.3e-14 52.8 0.0 4.4e-13 50.1 0.0 2.1 1 1 0 1 1 1 1 beta-acetyl hexosaminidase like Glyco_hydro_20b PF02838.15 ETO08779.1 - 0.012 16.4 0.0 0.019 15.7 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, domain 2 RVT_1 PF00078.27 ETO08780.1 - 5.2e-25 88.3 0.1 7.8e-25 87.7 0.1 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 ETO08780.1 - 0.00043 20.5 0.1 0.0055 16.9 0.0 2.2 2 0 0 2 2 2 1 RNase H Peptidase_C14 PF00656.22 ETO08781.1 - 6.5e-09 36.1 1.7 1.4e-08 35.0 1.6 1.6 1 1 0 1 1 1 1 Caspase domain Pax7 PF12360.8 ETO08782.1 - 0.054 13.7 0.1 0.15 12.3 0.1 1.8 1 0 0 1 1 1 0 Paired box protein 7 DnaJ PF00226.31 ETO08782.1 - 0.091 12.9 1.0 0.22 11.7 0.0 2.1 2 0 0 2 2 2 0 DnaJ domain BRE1 PF08647.11 ETO08782.1 - 2.7 8.1 12.9 5.1 7.2 1.0 3.6 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase Kelch_6 PF13964.6 ETO08783.1 - 1.1e-07 31.8 7.4 0.0085 16.4 0.1 4.9 7 0 0 7 7 7 2 Kelch motif Kelch_1 PF01344.25 ETO08783.1 - 2.2e-05 23.9 1.2 0.08 12.5 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO08783.1 - 0.00012 21.9 1.4 0.93 9.6 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO08783.1 - 0.00087 19.5 0.3 0.44 10.9 0.0 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08783.1 - 0.0025 17.7 8.0 0.035 14.1 1.0 3.9 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO08783.1 - 0.003 17.5 0.1 2 8.5 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Cupin_8 PF13621.6 ETO08784.1 - 1.7e-43 149.2 8.1 1.8e-42 145.8 8.1 2.8 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ETO08784.1 - 0.0031 17.0 0.1 0.011 15.2 0.0 2.0 2 0 0 2 2 2 1 Cupin superfamily protein JmjC PF02373.22 ETO08784.1 - 0.071 13.5 4.2 0.084 13.3 0.0 2.9 3 1 0 3 3 3 0 JmjC domain, hydroxylase Med12-LCEWAV PF12145.8 ETO08784.1 - 0.27 10.0 5.3 0.53 9.1 5.3 1.5 1 0 0 1 1 1 0 Eukaryotic Mediator 12 subunit domain s48_45 PF07422.13 ETO08784.1 - 3.2 8.4 7.3 0.29 11.7 1.0 2.7 2 1 0 2 2 2 0 Sexual stage antigen s48/45 domain YchF-GTPase_C PF06071.13 ETO08785.1 - 3.9e-39 132.7 0.6 9.8e-39 131.4 0.6 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF933) MMR_HSR1 PF01926.23 ETO08785.1 - 8.3e-21 74.2 0.0 2.1e-20 72.9 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO08785.1 - 2e-05 24.2 0.0 3.6e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Roc PF08477.13 ETO08785.1 - 0.00036 20.7 0.0 0.0011 19.1 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO08785.1 - 0.059 13.0 0.0 0.18 11.4 0.0 1.8 1 1 0 1 1 1 0 Ras family WD40 PF00400.32 ETO08786.1 - 1.6e-48 161.6 15.8 7.4e-10 39.3 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08786.1 - 4.6e-15 55.7 7.0 0.043 14.1 0.1 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08786.1 - 2e-09 37.2 3.9 2.1e-05 24.0 0.2 4.0 2 1 3 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO08786.1 - 2.1e-07 30.0 7.3 0.46 9.1 0.3 5.7 1 1 4 5 5 5 3 Nucleoporin Nup120/160 KH_1 PF00013.29 ETO08786.1 - 0.012 15.5 0.6 0.82 9.5 0.0 3.2 2 1 0 2 2 2 0 KH domain Cytochrom_D1 PF02239.16 ETO08786.1 - 0.019 13.5 0.3 0.18 10.3 0.1 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain MetallophosC PF16370.5 ETO08786.1 - 0.029 14.6 0.4 0.17 12.1 0.0 2.1 2 0 0 2 2 2 0 C terminal of Calcineurin-like phosphoesterase DUF1652 PF07865.11 ETO08786.1 - 0.044 13.6 0.0 35 4.3 0.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1652) Me-amine-dh_H PF06433.11 ETO08786.1 - 0.069 12.0 0.1 1.1 8.1 0.0 2.4 2 1 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) Str_synth PF03088.16 ETO08786.1 - 0.092 12.9 0.6 33 4.7 0.0 3.7 3 1 1 4 4 4 0 Strictosidine synthase Prot_ATP_ID_OB PF16450.5 ETO08786.1 - 0.25 11.3 0.5 4.6 7.3 0.0 3.2 4 0 0 4 4 4 0 Proteasomal ATPase OB C-terminal domain Neuraminidase PF18413.1 ETO08787.1 - 0.02 14.6 0.1 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 Neuraminidase-like domain WD40 PF00400.32 ETO08788.1 - 1.5e-08 35.1 1.0 2.8e-06 28.0 0.2 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08788.1 - 0.092 13.0 0.0 6.6 7.1 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DivIC PF04977.15 ETO08789.1 - 0.019 14.7 1.8 0.019 14.7 1.8 3.7 3 1 1 4 4 4 0 Septum formation initiator SWI-SNF_Ssr4 PF08549.10 ETO08789.1 - 0.22 10.1 11.1 0.27 9.8 11.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF883 PF05957.13 ETO08789.1 - 0.79 10.4 3.1 0.8 10.4 0.6 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Rpn9_C PF18261.1 ETO08789.1 - 1.9 8.2 9.9 1.7 8.3 0.4 2.8 2 0 0 2 2 2 0 Rpn9 C-terminal helix DUF2075 PF09848.9 ETO08789.1 - 3.9 6.6 14.3 7.8 5.6 14.3 1.4 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) NB-ARC PF00931.22 ETO08791.1 - 0.063 12.5 1.5 0.066 12.4 0.3 1.6 2 0 0 2 2 2 0 NB-ARC domain WD40 PF00400.32 ETO08792.1 - 0.0021 18.9 0.3 0.18 12.7 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat NACHT PF05729.12 ETO08793.1 - 7.1e-10 39.1 0.0 1.3e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO08793.1 - 0.00041 20.6 0.0 0.0018 18.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain ATPase PF06745.13 ETO08793.1 - 0.0048 16.3 4.2 0.016 14.6 0.1 3.2 3 1 1 4 4 4 1 KaiC AAA_18 PF13238.6 ETO08793.1 - 0.0092 16.5 1.5 0.026 15.1 0.0 2.6 3 0 0 3 3 3 1 AAA domain AAA_17 PF13207.6 ETO08793.1 - 0.013 16.0 0.0 0.066 13.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA PF00004.29 ETO08793.1 - 0.014 15.8 0.1 0.043 14.2 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO08793.1 - 0.031 14.7 0.3 0.56 10.6 0.2 2.5 2 1 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ETO08793.1 - 0.062 13.7 3.6 0.1 13.0 0.3 3.0 1 1 1 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO08793.1 - 0.24 11.9 1.2 0.86 10.1 0.0 2.5 3 0 0 3 3 3 0 ABC transporter WD40 PF00400.32 ETO08794.1 - 2.5e-55 183.2 22.0 5.6e-08 33.3 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08794.1 - 7.9e-16 58.1 3.6 0.00026 21.2 0.1 6.0 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08794.1 - 2.1e-10 40.1 5.5 0.0072 15.3 0.0 5.6 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO08794.1 - 1.4e-08 34.4 11.1 0.00014 21.3 0.1 3.6 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO08794.1 - 1.2e-07 30.8 6.2 0.027 13.1 0.1 6.2 2 2 5 7 7 7 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO08794.1 - 0.0017 17.0 0.0 0.014 13.9 0.1 2.2 2 1 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO08794.1 - 0.11 12.4 0.6 14 5.7 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Coat_X PF07552.11 ETO08794.1 - 0.36 10.7 7.0 3.1 7.7 1.3 3.3 3 0 0 3 3 3 0 Spore Coat Protein X and V domain zf-RING-like PF08746.11 ETO08795.1 - 2.4 8.6 8.4 0.21 11.9 2.6 2.3 2 1 0 2 2 2 0 RING-like domain SRP_TPR_like PF17004.5 ETO08796.1 - 0.062 13.3 0.1 0.13 12.3 0.1 1.5 1 0 0 1 1 1 0 Putative TPR-like repeat Folate_carrier PF01770.18 ETO08799.1 - 0.025 13.3 0.5 0.029 13.1 0.5 1.1 1 0 0 1 1 1 0 Reduced folate carrier RICTOR_N PF14664.6 ETO08799.1 - 0.03 13.3 0.5 0.036 13.0 0.5 1.1 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term FAM176 PF14851.6 ETO08799.1 - 0.15 11.7 2.9 0.22 11.2 2.9 1.3 1 0 0 1 1 1 0 FAM176 family UCMA PF17085.5 ETO08799.1 - 1.2 9.1 10.1 0.61 10.1 1.4 2.1 1 1 1 2 2 2 0 Unique cartilage matrix associated protein Pkinase PF00069.25 ETO08801.1 - 3.6e-08 33.1 0.0 5.3e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain G_glu_transpept PF01019.21 ETO08802.1 - 1.9e-72 244.7 0.0 1.3e-42 146.3 0.0 3.1 1 1 1 2 2 2 2 Gamma-glutamyltranspeptidase CAP_GLY PF01302.25 ETO08803.1 - 7.7e-05 22.6 0.1 0.007 16.4 0.0 2.2 2 0 0 2 2 2 2 CAP-Gly domain Imm17 PF15562.6 ETO08806.1 - 2.6 8.0 10.4 0.25 11.2 3.6 2.7 2 0 0 2 2 2 0 Immunity protein 17 DUF5137 PF17220.3 ETO08808.1 - 0.053 14.4 0.2 0.14 13.0 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF5137) Acyl-CoA_dh_N PF02771.16 ETO08809.1 - 1.1e-09 39.0 0.3 1.6e-09 38.4 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Dabb PF07876.12 ETO08809.1 - 0.055 14.1 0.0 0.13 12.9 0.0 1.6 1 1 0 1 1 1 0 Stress responsive A/B Barrel Domain AgrB PF04647.15 ETO08809.1 - 8.6 5.6 5.8 3.9 6.7 0.4 2.2 1 1 1 2 2 2 0 Accessory gene regulator B RSN1_7TM PF02714.15 ETO08810.1 - 4.5e-40 137.7 27.1 4.6e-39 134.4 27.1 2.0 1 1 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate PDR_CDR PF06422.12 ETO08810.1 - 0.067 13.1 0.4 0.067 13.1 0.4 2.3 3 0 0 3 3 3 0 CDR ABC transporter Sid-5 PF17204.3 ETO08810.1 - 0.91 9.7 4.5 0.58 10.4 0.4 2.4 2 0 0 2 2 2 0 Sid-5 family CLP_protease PF00574.23 ETO08811.1 - 3.7e-06 26.9 0.0 5.9e-05 23.0 0.0 2.1 2 0 0 2 2 2 1 Clp protease Aminotran_5 PF00266.19 ETO08812.1 - 8.9e-11 41.3 0.0 1.6e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V Transglut_i_TM PF14400.6 ETO08812.1 - 0.068 13.2 0.8 0.22 11.6 0.7 1.9 1 1 0 1 1 1 0 Inactive transglutaminase fused to 7 transmembrane helices Phage_TAC_1 PF06222.11 ETO08812.1 - 0.093 12.5 0.7 0.17 11.6 0.7 1.5 1 0 0 1 1 1 0 Phage tail assembly chaperone Dynamin_N PF00350.23 ETO08813.1 - 6e-06 26.4 0.0 6.6e-06 26.3 0.0 1.1 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ETO08813.1 - 0.00027 21.0 0.0 0.00032 20.8 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO08813.1 - 0.024 14.2 0.2 0.081 12.5 0.2 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain AIG1 PF04548.16 ETO08813.1 - 0.086 12.2 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 AIG1 family DUF5600 PF18150.1 ETO08814.1 - 3.3e-38 130.6 0.2 5.9e-38 129.7 0.2 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 ETO08814.1 - 1.2e-12 47.6 0.3 3.8e-12 46.1 0.1 1.9 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_1 PF00036.32 ETO08814.1 - 0.0074 15.8 0.0 0.02 14.4 0.0 1.8 1 0 0 1 1 1 1 EF hand HSP90 PF00183.18 ETO08815.1 - 3.5e-74 250.6 15.2 1e-57 196.3 10.7 3.1 1 1 2 3 3 3 3 Hsp90 protein PilN PF05137.13 ETO08815.1 - 0.012 15.8 0.0 0.036 14.2 0.0 1.9 2 0 0 2 2 2 0 Fimbrial assembly protein (PilN) Herpes_U15 PF05613.11 ETO08815.1 - 0.015 16.0 2.3 0.015 16.0 2.3 2.4 3 0 0 3 3 3 0 Human herpesvirus U15 protein SelK_SelG PF10961.8 ETO08815.1 - 0.64 10.7 2.5 2 9.1 0.1 2.5 1 1 1 2 2 2 0 Selenoprotein SelK_SelG Proteasome PF00227.26 ETO08816.1 - 4.2e-47 160.1 0.0 5.8e-47 159.7 0.0 1.1 1 0 0 1 1 1 1 Proteasome subunit WD40 PF00400.32 ETO08817.1 - 2.4e-23 82.0 13.4 4.5e-08 33.6 0.6 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08817.1 - 1.6e-09 37.9 1.8 0.0036 17.6 0.1 3.5 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08817.1 - 8.1e-07 28.1 5.7 0.2 10.3 0.1 3.8 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08817.1 - 0.0043 16.4 1.3 0.009 15.4 0.3 1.9 1 1 0 2 2 2 1 WD40-like domain Nucleoporin_N PF08801.11 ETO08817.1 - 0.01 14.6 2.0 0.02 13.7 0.7 2.1 1 1 2 3 3 3 1 Nup133 N terminal like DMAP1_like PF17024.5 ETO08819.1 - 0.04 14.0 0.6 1.9 8.6 0.3 2.4 2 0 0 2 2 2 0 Putative DMAP1-like CorA PF01544.18 ETO08820.1 - 9e-34 117.1 0.0 1.6e-33 116.3 0.0 1.4 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein HRDC PF00570.23 ETO08822.1 - 2.6e-09 37.0 0.0 6.3e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 HRDC domain VWA_CoxE PF05762.14 ETO08822.1 - 0.2 11.0 0.0 0.4 10.0 0.0 1.4 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein LRR_8 PF13855.6 ETO08823.1 - 3e-09 36.5 11.4 0.00015 21.5 1.2 3.0 1 1 2 3 3 3 3 Leucine rich repeat LRR_4 PF12799.7 ETO08823.1 - 3e-07 30.7 7.1 0.00018 21.8 1.6 3.6 1 1 3 4 4 4 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO08823.1 - 0.0015 18.4 3.1 26 5.2 0.0 4.7 5 0 0 5 5 5 1 Leucine Rich repeat LRR_1 PF00560.33 ETO08823.1 - 0.0027 18.0 7.0 5.2 8.0 0.1 4.5 4 1 0 4 4 4 2 Leucine Rich Repeat CHCH PF06747.13 ETO08823.1 - 0.055 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 CHCH domain GHL13 PF14883.6 ETO08826.1 - 0.0076 15.4 1.2 0.015 14.4 1.0 1.6 1 1 0 1 1 1 1 Hypothetical glycosyl hydrolase family 13 FliT PF05400.13 ETO08826.1 - 0.41 11.5 7.7 7.9 7.4 0.1 3.5 3 0 0 3 3 3 0 Flagellar protein FliT DUF2207 PF09972.9 ETO08826.1 - 3.1 6.5 8.1 0.28 9.9 3.1 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF573 PF04504.14 ETO08826.1 - 9.4 7.0 13.9 6.7 7.4 0.3 4.3 4 0 0 4 4 4 0 Protein of unknown function, DUF573 Hexokinase_2 PF03727.16 ETO08827.1 - 2.4e-33 115.6 0.1 1.8e-20 73.4 0.0 2.0 1 1 1 2 2 2 2 Hexokinase zf-MYND PF01753.18 ETO08828.1 - 0.15 12.2 13.4 0.25 11.4 13.4 1.4 1 0 0 1 1 1 0 MYND finger CbiA PF01656.23 ETO08830.1 - 4.2 7.4 4.9 23 5.1 4.9 2.3 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain CCDC-167 PF15188.6 ETO08831.1 - 0.11 12.9 8.0 0.2 12.0 8.0 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF5401 PF17380.2 ETO08831.1 - 0.55 8.2 11.3 0.57 8.2 11.3 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) PAF-AH_p_II PF03403.13 ETO08831.1 - 1.4 7.4 5.9 1.5 7.2 5.9 1.1 1 0 0 1 1 1 0 Platelet-activating factor acetylhydrolase, isoform II 7tm_3 PF00003.22 ETO08832.1 - 2.3e-19 70.1 8.2 2.3e-19 70.1 8.2 1.5 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR PQQ PF01011.21 ETO08832.1 - 0.0077 16.1 1.0 0.67 10.0 0.3 2.5 2 0 0 2 2 2 1 PQQ enzyme repeat EGF_alliinase PF04863.13 ETO08832.1 - 0.28 11.6 7.4 0.93 9.9 7.4 1.9 1 1 0 1 1 1 0 Alliinase EGF-like domain DUF4199 PF13858.6 ETO08832.1 - 0.77 10.1 14.4 0.23 11.8 3.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4199) DUF3040 PF11239.8 ETO08832.1 - 1.8 8.9 8.0 0.27 11.5 2.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) EGF_2 PF07974.13 ETO08832.1 - 6.8 7.2 16.2 0.074 13.4 8.2 2.0 2 0 0 2 2 2 0 EGF-like domain DUF2244 PF10003.9 ETO08832.1 - 9.9 5.8 7.1 1.9 8.2 1.9 2.3 1 1 1 2 2 2 0 Integral membrane protein (DUF2244) 7tm_3 PF00003.22 ETO08833.1 - 0.00032 20.5 11.8 0.00032 20.5 11.8 1.8 1 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR 7TM_GPCR_Srz PF10325.9 ETO08833.1 - 0.69 9.2 12.8 0.99 8.7 12.8 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srz Promethin PF16015.5 ETO08833.1 - 4.4 7.3 14.0 8.7 6.3 14.0 1.5 1 0 0 1 1 1 0 Promethin DUF2254 PF10011.9 ETO08833.1 - 5.1 5.8 6.5 7.4 5.3 6.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) TctB PF07331.11 ETO08833.1 - 8.8 6.6 14.8 20 5.4 14.8 1.7 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family EF-hand_4 PF12763.7 ETO08834.1 - 4.5e-05 23.3 0.0 7.5e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Auto_anti-p27 PF06677.12 ETO08835.1 - 1.1e-09 38.3 0.8 1.8e-09 37.6 0.8 1.3 1 0 0 1 1 1 1 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Dicty_REP PF05086.12 ETO08835.1 - 8.4 4.2 6.8 11 3.9 6.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein WD40 PF00400.32 ETO08836.1 - 3.5e-27 94.1 9.2 2.2e-11 44.1 0.2 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08836.1 - 2.3e-10 40.6 0.1 0.00067 19.9 0.0 4.0 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO08836.1 - 2.2e-07 30.2 0.1 0.016 14.2 0.0 3.8 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO08836.1 - 0.0018 18.2 0.1 7 6.7 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO08836.1 - 0.0083 15.5 2.0 0.031 13.6 0.0 2.9 3 1 0 3 3 3 1 WD40-like domain Nup160 PF11715.8 ETO08836.1 - 0.06 12.0 0.1 1.7 7.2 0.0 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO08837.1 - 1.7e-27 95.1 0.2 7.4e-09 36.1 0.0 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08837.1 - 3.1e-14 53.0 0.0 0.0022 18.3 0.0 3.7 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08837.1 - 2.4e-08 33.7 0.1 3.7e-05 23.2 0.1 2.1 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETO08837.1 - 2.7e-07 29.8 0.0 0.004 16.2 0.0 2.6 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO08837.1 - 2.1e-06 26.5 0.1 6.4e-05 21.7 0.0 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain eIF2A PF08662.11 ETO08837.1 - 1.4e-05 25.1 0.1 0.011 15.6 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 ETO08837.1 - 0.00019 20.6 0.1 0.41 9.7 0.0 2.2 1 1 0 2 2 2 2 VID27 C-terminal WD40-like domain Nup160 PF11715.8 ETO08837.1 - 0.001 17.9 0.1 0.0036 16.0 0.1 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO08837.1 - 0.02 14.5 0.0 0.33 10.5 0.0 2.0 1 1 0 1 1 1 0 PQQ-like domain SGL PF08450.12 ETO08837.1 - 0.022 14.3 0.0 0.31 10.6 0.0 2.0 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PQQ PF01011.21 ETO08837.1 - 0.022 14.6 0.0 1.8 8.6 0.0 2.9 3 0 0 3 3 3 0 PQQ enzyme repeat Coatomer_WDAD PF04053.14 ETO08837.1 - 0.031 13.3 0.0 2.2 7.2 0.0 2.1 1 1 1 2 2 2 0 Coatomer WD associated region PD40 PF07676.12 ETO08837.1 - 0.065 13.2 1.1 39 4.4 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Nop10p PF04135.12 ETO08837.1 - 0.085 12.9 0.7 20 5.3 0.0 2.6 3 0 0 3 3 3 0 Nucleolar RNA-binding protein, Nop10p family WD40 PF00400.32 ETO08838.1 - 2.4e-28 97.8 2.0 4e-08 33.8 0.3 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08838.1 - 3.8e-08 33.5 2.9 0.00073 19.8 0.2 2.9 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08838.1 - 1.1e-06 27.6 6.4 0.07 11.8 0.1 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO08838.1 - 1.5e-06 27.2 6.8 0.0034 16.2 0.2 2.8 1 1 2 3 3 3 3 Nup133 N terminal like WD40_like PF17005.5 ETO08838.1 - 3.6e-06 26.5 1.1 0.0037 16.6 0.1 2.1 2 0 0 2 2 2 2 WD40-like domain Ras PF00071.22 ETO08839.1 - 8.4e-24 84.0 0.1 1e-23 83.7 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO08839.1 - 6e-09 36.2 0.0 1e-08 35.4 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO08839.1 - 0.00051 19.5 0.1 0.00076 19.0 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family DLIC PF05783.11 ETO08839.1 - 0.0027 16.6 0.8 0.0037 16.2 0.8 1.2 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) GTP_EFTU PF00009.27 ETO08839.1 - 0.0042 16.7 0.0 0.0054 16.3 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF2325 PF10087.9 ETO08839.1 - 0.027 14.6 0.1 0.089 12.9 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) RsgA_GTPase PF03193.16 ETO08839.1 - 0.048 13.6 0.1 0.12 12.3 0.1 1.6 2 0 0 2 2 2 0 RsgA GTPase PIG-H PF10181.9 ETO08839.1 - 0.05 13.5 0.0 0.14 12.0 0.0 1.8 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component WD40 PF00400.32 ETO08840.1 - 5.1e-34 115.7 9.0 2.5e-09 37.6 0.2 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08840.1 - 3.9e-20 71.9 0.9 0.00012 22.2 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO08840.1 - 9e-12 44.9 2.2 1.2e-05 24.8 0.6 2.7 1 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO08840.1 - 3.1e-08 32.7 0.3 0.0033 16.1 0.0 3.8 1 1 3 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO08840.1 - 6.8e-07 29.4 0.3 0.00043 20.2 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO08840.1 - 8.2e-06 25.0 0.6 0.046 12.7 0.4 3.8 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ETO08840.1 - 0.00066 18.7 1.5 1.5 7.7 0.0 3.4 1 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO08840.1 - 0.00082 19.2 0.8 1.2 9.1 0.1 3.8 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO08840.1 - 0.0095 14.5 0.2 0.2 10.1 0.2 2.1 1 1 0 1 1 1 1 Cytochrome D1 heme domain DUF5474 PF17568.2 ETO08840.1 - 0.013 15.6 0.2 4.1 7.5 0.0 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5474) PQQ PF01011.21 ETO08840.1 - 0.048 13.6 0.0 2.8 8.0 0.0 3.0 3 1 0 3 3 3 0 PQQ enzyme repeat HEAT PF02985.22 ETO08841.1 - 1.1e-05 25.3 0.0 0.0003 20.8 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat Cnd1 PF12717.7 ETO08841.1 - 0.00015 21.8 6.6 0.022 14.8 1.5 2.3 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 GIT1_C PF12205.8 ETO08841.1 - 0.0002 21.4 1.9 0.0028 17.7 0.3 2.5 1 1 1 2 2 2 1 G protein-coupled receptor kinase-interacting protein 1 C term HEAT_2 PF13646.6 ETO08841.1 - 0.0003 21.1 0.0 0.00084 19.7 0.0 1.7 1 0 0 1 1 1 1 HEAT repeats NLE PF08154.12 ETO08841.1 - 0.0056 17.2 4.1 1.1 9.8 0.3 3.1 2 1 1 3 3 3 2 NLE (NUC135) domain Activator-TraM PF11657.8 ETO08841.1 - 0.015 15.1 0.3 0.079 12.8 0.1 2.1 1 1 0 2 2 2 0 Transcriptional activator TraM HEAT_EZ PF13513.6 ETO08841.1 - 0.021 15.3 0.0 0.046 14.2 0.0 1.6 1 0 0 1 1 1 0 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO08841.1 - 0.028 15.0 0.1 0.22 12.1 0.0 2.3 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region DUF5071 PF16804.5 ETO08841.1 - 0.04 14.2 1.2 0.27 11.5 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5071) RTP1_C1 PF10363.9 ETO08841.1 - 0.044 14.0 0.1 0.11 12.7 0.1 1.8 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 AF0941-like PF14591.6 ETO08841.1 - 0.091 13.3 2.7 0.23 12.0 2.7 1.8 1 1 0 1 1 1 0 AF0941-like Spore_III_AB PF09548.10 ETO08841.1 - 0.18 11.9 1.4 1.1 9.3 0.2 2.1 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF3349 PF11829.8 ETO08841.1 - 0.41 11.4 3.4 20 6.1 0.0 3.5 2 1 3 5 5 5 0 Protein of unknown function (DUF3349) XkdW PF09636.10 ETO08841.1 - 2 8.6 5.9 11 6.2 0.2 3.5 1 1 2 4 4 4 0 XkdW protein COX4_pro_2 PF07835.12 ETO08842.1 - 0.44 10.7 2.4 11 6.2 0.3 2.5 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV eRF1_3 PF03465.15 ETO08843.1 - 1.1e-06 29.0 0.2 1.1e-05 25.8 0.2 2.2 1 1 0 1 1 1 1 eRF1 domain 3 CBM_26 PF16824.5 ETO08843.1 - 0.038 14.1 0.0 0.048 13.8 0.0 1.2 1 0 0 1 1 1 0 C-terminal carbohydrate-binding module PHD PF00628.29 ETO08844.1 - 1.6e-09 37.5 6.1 5e-09 35.9 6.1 1.9 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H PF13771.6 ETO08844.1 - 0.004 17.4 2.7 0.004 17.4 2.7 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain Macoilin PF09726.9 ETO08844.1 - 0.99 7.9 14.4 1.5 7.3 14.4 1.3 1 0 0 1 1 1 0 Macoilin family PHD_4 PF16866.5 ETO08844.1 - 3.6 7.7 10.1 2 8.6 6.2 2.6 2 1 0 2 2 2 0 PHD-finger Ras PF00071.22 ETO08845.1 - 1.1e-30 106.4 0.0 1.5e-28 99.4 0.0 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO08845.1 - 2e-07 31.2 0.0 0.00014 22.1 0.0 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO08845.1 - 0.0004 19.9 0.2 0.16 11.4 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family RVT_1 PF00078.27 ETO08846.1 - 7.6e-44 149.9 0.2 1.6e-43 148.8 0.2 1.6 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 ETO08846.1 - 3.1e-18 66.3 0.0 8.4e-18 64.9 0.0 1.8 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 ETO08846.1 - 1.8e-15 56.8 2.2 5.5e-15 55.3 1.0 2.5 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase zf-RVT PF13966.6 ETO08846.1 - 8.4e-06 26.4 0.8 8.4e-06 26.4 0.8 3.8 4 0 0 4 4 4 1 zinc-binding in reverse transcriptase RVT_3 PF13456.6 ETO08846.1 - 0.021 14.6 0.0 0.12 12.2 0.0 2.4 3 0 0 3 3 3 0 Reverse transcriptase-like Pyridoxal_deC PF00282.19 ETO08847.1 - 1.4e-17 63.5 0.0 2.7e-17 62.5 0.0 1.4 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain PARP PF00644.20 ETO08848.1 - 2.4e-08 33.8 0.0 2.4e-08 33.8 0.0 3.5 3 1 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain BUD22 PF09073.10 ETO08848.1 - 0.00036 20.0 51.7 0.005 16.2 17.0 2.3 2 0 0 2 2 2 2 BUD22 Cwf_Cwc_15 PF04889.12 ETO08848.1 - 0.0045 16.8 18.1 0.0045 16.8 18.1 2.2 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein IBR PF01485.21 ETO08848.1 - 0.024 14.8 11.6 0.11 12.7 11.6 2.2 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain SpoIIIAH PF12685.7 ETO08848.1 - 0.7 9.7 33.2 0.68 9.7 8.6 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF913 PF06025.12 ETO08848.1 - 4.2 6.2 26.7 0.66 8.9 8.0 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO08848.1 - 4.6 5.9 47.9 0.35 9.6 20.8 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SURF2 PF05477.11 ETO08848.1 - 7.6 6.2 51.1 0.53 9.9 23.7 2.2 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Gti1_Pac2 PF09729.9 ETO08848.1 - 8.4 6.4 36.9 8 6.5 16.8 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Afi1 PF07792.12 ETO08848.1 - 9.9 6.7 43.1 0.1 13.0 12.6 2.7 2 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 ETO08848.1 - 10 4.8 30.0 3.7 6.2 7.0 2.1 2 0 0 2 2 2 0 Presenilin Arf PF00025.21 ETO08849.1 - 0.028 13.9 0.0 0.041 13.3 0.0 1.4 1 1 0 1 1 1 0 ADP-ribosylation factor family DUF4820 PF16091.5 ETO08850.1 - 0.23 10.8 2.0 0.33 10.3 2.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Secretin_N_2 PF07655.13 ETO08850.1 - 1.2 9.7 11.2 2.5 8.7 11.2 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DENN PF02141.21 ETO08851.1 - 6.7e-42 143.6 3.6 6.1e-34 117.6 0.4 2.0 1 1 1 2 2 2 2 DENN (AEX-3) domain Ank_2 PF12796.7 ETO08853.1 - 4.3e-10 40.1 0.0 4.1e-05 24.1 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO08853.1 - 1.2e-06 28.3 0.2 0.47 11.2 0.0 4.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO08853.1 - 3e-06 27.7 0.0 0.14 12.8 0.0 3.4 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO08853.1 - 0.00048 20.4 0.0 1.3 9.6 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank_5 PF13857.6 ETO08853.1 - 0.038 14.3 0.0 0.55 10.6 0.0 2.7 3 0 0 3 3 3 0 Ankyrin repeats (many copies) Kelch_2 PF07646.15 ETO08854.1 - 0.00094 19.1 2.9 1.1 9.4 0.0 3.0 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO08854.1 - 0.0014 18.6 2.5 0.062 13.3 0.8 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO08854.1 - 0.0027 17.2 0.5 0.075 12.6 0.3 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO08854.1 - 0.028 14.4 0.3 8.1 6.5 0.1 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO08854.1 - 0.045 14.0 1.5 10 6.6 0.3 2.8 1 1 1 2 2 2 0 Kelch motif Hyphal_reg_CWP PF11765.8 ETO08855.1 - 0.0093 14.9 9.0 0.011 14.7 9.0 1.2 1 0 0 1 1 1 1 Hyphally regulated cell wall protein N-terminal UBA2_C PF16195.5 ETO08855.1 - 0.2 12.4 0.7 0.35 11.6 0.3 1.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus Ribosomal_L23 PF00276.20 ETO08856.1 - 0.0037 17.6 0.4 0.0083 16.5 0.2 1.7 2 0 0 2 2 2 1 Ribosomal protein L23 DUF4416 PF14385.6 ETO08856.1 - 0.059 13.3 0.1 0.085 12.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4416) BPL_N PF09825.9 ETO08857.1 - 3.4e-43 148.2 0.1 4.6e-43 147.7 0.1 1.1 1 0 0 1 1 1 1 Biotin-protein ligase, N terminal Neur_chan_memb PF02932.16 ETO08858.1 - 0.98 9.4 3.6 1.1 9.2 3.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO08858.1 - 6.8 5.3 9.2 9.2 4.9 9.2 1.2 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO08860.1 - 3.9e-18 65.5 11.4 3.9e-06 27.5 1.1 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08860.1 - 1.4e-08 34.9 1.6 0.011 16.0 0.1 3.5 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08860.1 - 2.7e-07 29.6 0.8 0.15 10.6 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Kelch_5 PF13854.6 ETO08861.1 - 0.00014 21.8 1.7 1.9 8.6 0.0 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO08861.1 - 0.00032 20.9 0.2 2.2 8.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO08861.1 - 0.0063 16.1 0.1 0.25 11.0 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO08861.1 - 0.012 15.6 0.8 15 5.7 0.1 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain PsaN PF05479.11 ETO08862.1 - 0.088 13.0 0.2 2.5 8.3 0.1 2.1 2 0 0 2 2 2 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) RVT_1 PF00078.27 ETO08862.1 - 0.11 12.0 0.5 0.7 9.4 0.1 2.1 1 1 0 2 2 2 0 Reverse transcriptase (RNA-dependent DNA polymerase) Cyclin_N PF00134.23 ETO08863.1 - 1.3e-08 34.7 0.8 1.3e-08 34.7 0.8 2.2 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C_2 PF16899.5 ETO08863.1 - 2.2e-08 34.4 1.3 2.2e-08 34.4 1.3 3.0 3 1 1 4 4 4 1 Cyclin C-terminal domain DUF842 PF05811.13 ETO08863.1 - 0.013 15.2 1.9 0.013 15.2 1.9 2.0 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF842) Cyclin_C PF02984.19 ETO08863.1 - 0.48 10.5 7.7 0.07 13.2 1.9 2.7 3 2 0 3 3 3 0 Cyclin, C-terminal domain zf-C4H2 PF10146.9 ETO08863.1 - 0.83 9.9 6.2 1.8 8.8 6.2 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein Mt_ATP-synt_D PF05873.12 ETO08863.1 - 0.93 9.3 9.3 0.82 9.5 0.9 3.8 3 1 1 4 4 4 0 ATP synthase D chain, mitochondrial (ATP5H) PI3_PI4_kinase PF00454.27 ETO08865.1 - 3.2e-26 92.6 0.1 4.8e-26 92.1 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ETO08865.1 - 1.8e-09 37.2 0.7 4.6e-09 35.9 0.7 1.7 1 0 0 1 1 1 1 FATC domain NUC194 PF08163.12 ETO08866.1 - 3e-40 138.4 0.1 3e-40 138.4 0.1 3.5 3 1 0 3 3 3 1 NUC194 domain FAT PF02259.23 ETO08866.1 - 1.3e-10 41.0 15.5 2.9e-10 39.9 9.4 4.0 4 1 0 4 4 4 1 FAT domain PI3_PI4_kinase PF00454.27 ETO08866.1 - 0.00014 21.7 0.1 0.00051 19.9 0.1 2.0 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase WD40 PF00400.32 ETO08871.1 - 3.2e-18 65.7 11.9 2.3e-06 28.2 0.1 5.4 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08871.1 - 9.8e-06 25.8 0.2 0.24 11.7 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08871.1 - 0.00066 18.4 1.0 1.8 7.1 0.1 3.4 1 1 1 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO08871.1 - 0.00077 19.5 0.8 0.043 13.9 0.1 2.8 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region Methyltransf_31 PF13847.6 ETO08872.1 - 0.17 11.6 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain WD40 PF00400.32 ETO08873.1 - 8e-28 96.1 1.5 4e-09 36.9 0.0 6.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08873.1 - 2.6e-10 40.4 0.8 0.00039 20.7 0.1 5.0 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO08873.1 - 3.8e-08 33.4 1.2 0.0014 18.6 0.0 3.5 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO08873.1 - 2.8e-06 27.1 0.0 3.4 7.7 0.0 4.9 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO08873.1 - 1e-05 24.7 0.1 0.047 12.7 0.0 3.6 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO08873.1 - 5.2e-05 23.4 1.2 0.18 12.2 0.3 2.9 2 0 0 2 2 2 2 Kelch motif Cytochrom_D1 PF02239.16 ETO08873.1 - 0.00037 19.1 0.0 0.12 10.9 0.0 2.5 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO08873.1 - 0.0019 17.0 1.8 2.6 6.7 0.0 3.1 1 1 2 3 3 3 2 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO08873.1 - 0.07 12.8 5.0 19 5.0 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Kelch_5 PF13854.6 ETO08873.1 - 0.73 9.9 3.4 1 9.4 1.3 2.1 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO08874.1 - 2.4e-11 44.0 3.1 3.9e-05 24.3 0.0 3.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO08874.1 - 0.0014 17.3 0.1 0.59 8.7 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Apolipoprotein PF01442.18 ETO08875.1 - 0.0038 17.1 12.2 0.0055 16.6 5.9 2.6 1 1 1 2 2 2 2 Apolipoprotein A1/A4/E domain ApoO PF09769.9 ETO08875.1 - 0.16 11.9 5.2 6.7 6.7 1.0 3.1 3 1 0 3 3 3 0 Apolipoprotein O Phage_GP20 PF06810.11 ETO08875.1 - 0.2 11.4 15.9 0.16 11.7 10.1 2.8 2 1 0 2 2 2 0 Phage minor structural protein GP20 DUF948 PF06103.11 ETO08875.1 - 0.3 11.4 7.0 1.6 9.0 1.2 3.2 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) GrpE PF01025.19 ETO08875.1 - 1.9 8.2 19.8 3.4 7.3 0.5 3.5 1 1 1 2 2 2 0 GrpE FAM184 PF15665.5 ETO08875.1 - 2 8.1 23.2 2.3 8.0 7.8 3.2 2 1 1 3 3 3 0 Family with sequence similarity 184, A and B DUF2203 PF09969.9 ETO08875.1 - 3.1 8.5 12.9 4.8 7.9 2.2 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) SLATT_fungal PF18142.1 ETO08875.1 - 4.3 7.4 6.9 21 5.1 3.4 2.8 1 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain ACCA PF03255.14 ETO08875.1 - 7 6.5 12.1 2.4 8.0 4.7 3.0 3 1 1 4 4 4 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF3106 PF11304.8 ETO08875.1 - 8.3 6.9 14.0 4.1 7.9 5.9 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3106) DUF4407 PF14362.6 ETO08875.1 - 9 5.5 7.8 34 3.7 7.7 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RPEL PF02755.15 ETO08876.1 - 7e-09 35.1 10.2 0.00089 18.9 0.6 4.2 4 1 0 4 4 4 3 RPEL repeat PsaD PF02531.16 ETO08876.1 - 0.021 14.4 1.1 0.03 13.9 1.1 1.2 1 0 0 1 1 1 0 PsaD Secretin_N_2 PF07655.13 ETO08876.1 - 0.39 11.3 12.5 0.69 10.5 12.5 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain RPEL PF02755.15 ETO08877.1 - 2.7e-05 23.7 9.5 0.01 15.5 1.2 3.7 3 1 0 3 3 3 2 RPEL repeat UPF0051 PF01458.17 ETO08877.1 - 0.0046 16.7 5.0 0.0057 16.4 5.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein family (UPF0051) CARD PF00619.21 ETO08877.1 - 0.098 12.7 0.4 0.22 11.6 0.0 1.8 2 0 0 2 2 2 0 Caspase recruitment domain Macoilin PF09726.9 ETO08877.1 - 4.7 5.7 14.5 5.8 5.4 14.5 1.2 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 ETO08878.1 - 2.8e-60 204.6 24.9 7.4e-60 203.2 24.9 1.6 1 1 0 1 1 1 1 Nop14-like family Hemocyanin_M PF00372.19 ETO08878.1 - 0.0047 16.1 0.2 0.01 15.0 0.2 1.5 1 0 0 1 1 1 1 Hemocyanin, copper containing domain BAF1_ABF1 PF04684.13 ETO08879.1 - 0.88 8.6 27.4 1.1 8.3 27.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Nop14 PF04147.12 ETO08879.1 - 1 7.5 40.0 1.3 7.1 40.0 1.0 1 0 0 1 1 1 0 Nop14-like family Nop14 PF04147.12 ETO08880.1 - 2.4e-16 59.2 23.9 4.8e-10 38.3 15.3 2.0 2 0 0 2 2 2 2 Nop14-like family Musclin PF11037.8 ETO08880.1 - 0.005 16.8 1.5 0.0064 16.4 0.1 1.9 2 0 0 2 2 2 1 Insulin-resistance promoting peptide in skeletal muscle WYL_3 PF18488.1 ETO08880.1 - 0.027 14.9 0.2 0.12 12.8 0.2 2.2 1 0 0 1 1 1 0 WYL domain DUF5069 PF16798.5 ETO08880.1 - 0.11 12.6 2.2 0.26 11.5 0.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF5069) DUF2802 PF10975.8 ETO08880.1 - 0.94 9.7 7.5 5.3 7.2 0.0 3.9 3 3 1 4 4 4 0 Protein of unknown function (DUF2802) DUF4248 PF14053.6 ETO08881.1 - 0.32 11.0 1.9 2 8.5 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4248) CENP-F_leu_zip PF10473.9 ETO08882.1 - 0.0039 17.2 9.2 0.0039 17.2 9.2 2.2 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.12 ETO08882.1 - 0.075 13.7 12.3 0.18 12.4 2.4 3.0 1 1 2 3 3 3 0 SlyX DUF2205 PF10224.9 ETO08882.1 - 0.1 12.6 8.5 0.11 12.6 7.0 1.8 1 1 1 2 2 2 0 Short coiled-coil protein ATG16 PF08614.11 ETO08882.1 - 0.11 12.7 11.6 0.61 10.3 11.7 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF3450 PF11932.8 ETO08882.1 - 0.23 10.7 12.5 0.34 10.2 10.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) COQ7 PF03232.13 ETO08882.1 - 1.2 8.8 4.2 3.5 7.4 1.0 2.4 1 1 1 2 2 2 0 Ubiquinone biosynthesis protein COQ7 Uso1_p115_C PF04871.13 ETO08882.1 - 2.3 8.6 13.3 3.8 7.9 12.9 1.5 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1090 PF06476.12 ETO08882.1 - 6.8 6.9 18.1 2.2 8.4 7.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1090) DNA_pol_B PF00136.21 ETO08884.1 - 1e-143 479.4 3.0 1.4e-143 479.0 3.0 1.2 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ETO08884.1 - 3.1e-76 256.7 0.0 5.2e-76 256.0 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain zf-C4pol PF14260.6 ETO08884.1 - 1.5e-17 63.8 6.7 3.9e-17 62.5 6.7 1.8 1 0 0 1 1 1 1 C4-type zinc-finger of DNA polymerase delta DNA_pol_A_exo1 PF01612.20 ETO08884.1 - 0.0047 16.7 0.1 4.3 7.0 0.0 2.5 2 0 0 2 2 2 2 3'-5' exonuclease DNA_pol_B_2 PF03175.13 ETO08884.1 - 0.0062 15.5 0.1 0.0062 15.5 0.1 2.5 3 0 0 3 3 3 1 DNA polymerase type B, organellar and viral DNA_pol_B_exo2 PF10108.9 ETO08884.1 - 0.068 12.8 0.0 0.14 11.8 0.0 1.5 1 0 0 1 1 1 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB DnaJ_CXXCXGXG PF00684.19 ETO08884.1 - 0.95 9.9 7.9 2.3 8.6 7.9 1.7 1 0 0 1 1 1 0 DnaJ central domain FRB_dom PF08771.11 ETO08885.1 - 0.055 13.9 0.6 0.87 10.0 0.0 2.3 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain TMCO5 PF14992.6 ETO08886.1 - 0.0023 17.5 6.7 0.0026 17.4 6.7 1.0 1 0 0 1 1 1 1 TMCO5 family SOGA PF11365.8 ETO08886.1 - 0.0043 18.1 7.0 0.0058 17.7 7.0 1.2 1 1 0 1 1 1 1 Protein SOGA ATG16 PF08614.11 ETO08886.1 - 0.027 14.7 7.7 0.073 13.3 4.6 2.0 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) CENP-Q PF13094.6 ETO08886.1 - 0.028 14.6 9.3 0.09 13.0 9.3 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DHHA1 PF02272.19 ETO08886.1 - 0.27 11.7 2.9 0.24 11.8 1.8 1.4 1 1 0 1 1 1 0 DHHA1 domain GIT_CC PF16559.5 ETO08886.1 - 0.33 10.8 6.4 0.53 10.2 1.9 2.4 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF724 PF05266.14 ETO08886.1 - 0.75 9.6 10.5 0.23 11.2 7.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) PRKG1_interact PF15898.5 ETO08886.1 - 0.89 10.5 10.1 1.5 9.8 9.9 1.6 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 ETO08886.1 - 0.96 10.1 8.2 0.39 11.4 5.2 1.7 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 ETO08886.1 - 1.8 8.4 10.8 0.35 10.7 5.2 2.2 2 1 0 2 2 2 0 Septum formation initiator Fib_alpha PF08702.10 ETO08886.1 - 1.8 8.7 10.1 3.9 7.6 10.1 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family End3 PF12761.7 ETO08886.1 - 1.9 8.6 10.6 5.4 7.1 10.6 1.7 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 SlyX PF04102.12 ETO08886.1 - 5.7 7.6 9.2 1.7 9.3 5.6 1.9 2 0 0 2 2 2 0 SlyX SAC3_GANP PF03399.16 ETO08887.1 - 0.038 13.4 0.6 0.043 13.2 0.6 1.1 1 0 0 1 1 1 0 SAC3/GANP family WD40 PF00400.32 ETO08888.1 - 3.8e-05 24.3 2.3 0.7 10.9 0.1 3.9 5 0 0 5 5 5 2 WD domain, G-beta repeat PsiF_repeat PF07769.14 ETO08888.1 - 0.048 13.6 0.0 0.087 12.7 0.0 1.4 1 0 0 1 1 1 0 psiF repeat FAM176 PF14851.6 ETO08889.1 - 0.004 16.8 0.8 0.0054 16.4 0.8 1.2 1 0 0 1 1 1 1 FAM176 family DUF2956 PF11169.8 ETO08889.1 - 0.016 15.3 3.6 0.026 14.7 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Peptidase_S49_N PF08496.10 ETO08889.1 - 0.023 14.8 2.9 0.029 14.4 2.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SR-25 PF10500.9 ETO08889.1 - 0.026 14.2 5.7 0.031 13.9 5.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AP3D1 PF06375.11 ETO08889.1 - 0.027 14.7 10.4 0.042 14.1 10.4 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 OAD_gamma PF04277.13 ETO08889.1 - 0.32 11.6 1.0 0.54 10.9 1.0 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUSP PF06337.12 ETO08889.1 - 2 9.1 5.4 4.9 7.8 5.4 1.8 1 1 0 1 1 1 0 DUSP domain UPF0542 PF15086.6 ETO08889.1 - 7.4 6.6 12.7 2.7 8.0 9.5 1.9 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 Importin_rep_6 PF18829.1 ETO08890.1 - 0.1 12.7 1.5 7.8 6.7 0.0 2.7 3 0 0 3 3 3 0 Importin repeat 6 AF0941-like PF14591.6 ETO08892.1 - 0.14 12.7 1.0 2.4 8.8 0.0 2.5 1 1 1 2 2 2 0 AF0941-like DUF3273 PF11677.8 ETO08894.1 - 0.1 11.9 1.4 0.13 11.5 1.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3273) PPR_2 PF13041.6 ETO08895.1 - 0.0011 19.1 0.2 0.0032 17.6 0.2 1.9 1 0 0 1 1 1 1 PPR repeat family PPR PF01535.20 ETO08895.1 - 0.079 13.2 0.1 0.22 11.9 0.1 1.8 1 0 0 1 1 1 0 PPR repeat Ran_BP1 PF00638.18 ETO08896.1 - 1.9e-05 24.9 1.0 2.6e-05 24.5 0.1 1.7 2 0 0 2 2 2 1 RanBP1 domain UPF0542 PF15086.6 ETO08900.1 - 0.0043 17.0 1.9 0.0043 17.0 1.9 2.2 2 0 0 2 2 2 1 Uncharacterised protein family UPF0542 Saf_2TM PF18303.1 ETO08900.1 - 4.5 6.8 8.0 4.1 7.0 0.3 2.3 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain UCH PF00443.29 ETO08901.1 - 2.5e-07 30.5 0.3 5.6e-07 29.3 0.3 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Presenilin PF01080.17 ETO08901.1 - 1.2 7.9 6.8 1.7 7.3 6.8 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO08901.1 - 1.4 7.2 9.8 2.1 6.6 9.8 1.3 1 0 0 1 1 1 0 Menin RP-C_C PF11800.8 ETO08901.1 - 1.7 8.7 4.4 2.8 8.0 4.4 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Pex14_N PF04695.13 ETO08901.1 - 6 7.5 9.5 13 6.4 9.5 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TcA_RBD PF18518.1 ETO08902.1 - 0.61 10.4 4.0 2.9 8.2 1.4 2.1 1 1 1 2 2 2 0 TcA receptor binding domain zf-CCHC PF00098.23 ETO08904.1 - 0.00087 19.3 1.5 0.00087 19.3 1.5 2.6 3 0 0 3 3 3 1 Zinc knuckle zf-CCHC_4 PF14392.6 ETO08904.1 - 0.15 11.8 10.4 1.7 8.4 1.8 2.5 2 0 0 2 2 2 0 Zinc knuckle Brr6_like_C_C PF10104.9 ETO08904.1 - 0.39 10.5 5.7 0.65 9.8 5.7 1.4 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Mucin PF01456.17 ETO08906.1 - 0.036 14.1 10.1 0.06 13.3 10.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein BACK PF07707.15 ETO08907.1 - 1.7e-08 34.5 3.7 1.1e-07 31.9 0.6 3.0 2 1 0 2 2 2 1 BTB And C-terminal Kelch BTB PF00651.31 ETO08907.1 - 1.3e-07 31.8 0.2 3.4e-07 30.5 0.2 1.6 1 0 0 1 1 1 1 BTB/POZ domain MlaC PF05494.12 ETO08907.1 - 0.00056 19.7 0.4 0.0014 18.5 0.1 1.7 2 0 0 2 2 2 1 MlaC protein WD40 PF00400.32 ETO08908.1 - 6.9e-42 140.6 28.5 8.9e-08 32.7 1.2 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08908.1 - 6e-13 48.9 2.6 0.0028 17.9 0.0 5.6 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08908.1 - 1e-08 34.3 10.4 0.056 12.1 0.3 5.8 1 1 2 6 6 6 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO08908.1 - 3e-06 27.8 2.3 1.3e-05 25.7 2.3 2.2 1 0 0 1 1 1 1 TRAF-type zinc finger WD40_like PF17005.5 ETO08908.1 - 0.0015 17.9 13.3 0.0025 17.2 0.4 4.8 3 2 2 5 5 5 1 WD40-like domain Exonuc_VII_L PF02601.15 ETO08908.1 - 4 6.9 8.7 6.9 6.1 8.7 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ETO08908.1 - 4.1 6.7 9.0 6.4 6.0 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KASH_CCD PF14662.6 ETO08908.1 - 5 6.9 32.0 0.52 10.1 21.1 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH ABC2_membrane_3 PF12698.7 ETO08909.1 - 9.7e-47 159.7 73.5 1.4e-39 136.2 20.1 3.6 3 0 0 3 3 3 2 ABC-2 family transporter protein ABC_tran PF00005.27 ETO08909.1 - 5.7e-43 146.7 0.9 4e-20 72.7 0.0 3.8 4 0 0 4 4 3 2 ABC transporter AAA_21 PF13304.6 ETO08909.1 - 6.4e-19 68.9 5.3 2.6e-07 30.8 0.1 4.9 4 1 1 5 5 5 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO08909.1 - 1.7e-07 31.0 0.0 0.042 13.3 0.0 3.0 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO08909.1 - 7.6e-05 22.9 0.0 0.063 13.5 0.0 3.7 3 1 0 3 3 3 1 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 ETO08909.1 - 0.0044 16.7 3.4 0.65 9.6 0.2 2.5 2 0 0 2 2 2 2 SRP54-type protein, GTPase domain SUIM_assoc PF16619.5 ETO08909.1 - 0.0065 16.5 2.2 0.021 14.9 2.2 1.8 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 AAA_23 PF13476.6 ETO08909.1 - 0.018 15.5 18.1 0.18 12.3 0.0 3.8 4 0 0 4 4 4 0 AAA domain AAA_29 PF13555.6 ETO08909.1 - 0.041 13.6 0.8 8 6.3 0.0 3.1 3 0 0 3 3 3 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO08909.1 - 0.096 12.6 3.2 0.34 10.8 0.0 2.9 3 0 0 3 3 3 0 RsgA GTPase Pet20 PF08692.10 ETO08909.1 - 0.16 12.7 1.1 0.7 10.6 1.1 2.1 1 0 0 1 1 1 0 Mitochondrial protein Pet20 DUF4636 PF15468.6 ETO08909.1 - 1.6 8.4 7.8 1 9.0 5.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4636) Secretin_N_2 PF07655.13 ETO08910.1 - 0.026 15.1 10.5 0.026 15.1 10.5 3.0 2 0 0 2 2 2 0 Secretin N-terminal domain DUF5305 PF17231.2 ETO08910.1 - 4 6.8 10.3 13 5.1 8.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5305) WD40 PF00400.32 ETO08911.1 - 7.4e-39 131.0 34.0 4.2e-08 33.7 0.9 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08911.1 - 7.2e-14 51.9 0.4 0.0093 16.2 0.0 4.6 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08911.1 - 3e-10 39.4 5.8 0.0025 16.6 0.6 3.3 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08911.1 - 0.00029 20.3 10.1 0.03 13.7 0.5 4.8 1 1 4 6 6 6 2 WD40-like domain DUF4722 PF15849.5 ETO08912.1 - 0.092 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4722) DUF5517 PF17639.2 ETO08913.1 - 0.0088 16.3 0.1 0.023 15.0 0.1 1.7 1 0 0 1 1 1 1 Family of unknown function (DUF5517) MRP-S33 PF08293.11 ETO08913.1 - 0.049 13.9 0.1 0.079 13.2 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit S27 zf-CCHC PF00098.23 ETO08915.1 - 0.00062 19.7 1.0 0.00062 19.7 1.0 2.6 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 ETO08915.1 - 0.31 10.8 9.5 0.99 9.2 1.0 2.5 2 0 0 2 2 2 0 Zinc knuckle ArgoL2 PF16488.5 ETO08917.1 - 0.18 12.2 0.0 0.39 11.1 0.0 1.6 1 0 0 1 1 1 0 Argonaute linker 2 domain Tubulin_C PF03953.17 ETO08919.1 - 4e-37 127.2 0.0 5e-37 126.9 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain RepA_C PF04796.12 ETO08920.1 - 0.036 14.1 1.4 2.4 8.2 0.0 2.4 2 0 0 2 2 2 0 Plasmid encoded RepA protein N_Asn_amidohyd PF14736.6 ETO08920.1 - 0.058 12.5 0.1 0.097 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein N-terminal asparagine amidohydrolase Armet PF10208.9 ETO08921.1 - 0.00029 20.8 2.7 0.00029 20.8 2.7 1.8 2 0 0 2 2 2 1 Degradation arginine-rich protein for mis-folding DUF3314 PF11771.8 ETO08921.1 - 0.056 13.6 3.6 0.059 13.5 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3314) Tubulin PF00091.25 ETO08922.1 - 2e-44 152.2 0.0 2.7e-44 151.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO08922.1 - 6.5e-07 29.6 0.0 1.6e-06 28.3 0.0 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.25 ETO08922.1 - 0.0063 16.4 0.0 0.016 15.1 0.0 1.6 2 0 0 2 2 2 1 Lipase (class 3) Rad21_Rec8_N PF04825.13 ETO08922.1 - 0.12 12.6 0.1 1.8 8.7 0.1 2.2 2 0 0 2 2 2 0 N terminus of Rad21 / Rec8 like protein Misat_Tub_SegII PF10644.9 ETO08922.1 - 0.17 12.2 0.1 0.4 11.0 0.0 1.7 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain Pox_polyA_pol PF03296.13 ETO08923.1 - 0.058 13.3 1.3 0.12 12.3 0.1 1.9 1 1 1 2 2 2 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain DUF4883 PF16224.5 ETO08923.1 - 0.075 13.3 0.3 0.15 12.4 0.3 1.4 1 0 0 1 1 1 0 DOmain of unknown function (DUF4883) Endothelin PF00322.17 ETO08923.1 - 0.5 10.0 0.1 0.5 10.0 0.1 2.2 3 0 0 3 3 3 0 Endothelin family CPL PF08144.11 ETO08924.1 - 0.029 14.7 0.8 0.029 14.7 0.8 1.6 2 0 0 2 2 2 0 CPL (NUC119) domain DUF641 PF04859.12 ETO08924.1 - 0.043 14.1 2.3 0.049 14.0 0.1 1.8 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) PRP1_N PF06424.12 ETO08924.1 - 0.05 14.0 1.8 0.06 13.7 1.8 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF3216 PF11505.8 ETO08924.1 - 0.33 11.2 3.3 3 8.1 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3216) NESP55 PF06390.12 ETO08924.1 - 0.89 9.1 3.2 1.1 8.8 3.2 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) ApeA_NTD1 PF18862.1 ETO08926.1 - 0.03 13.9 0.1 0.04 13.5 0.1 1.3 1 0 0 1 1 1 0 ApeA N-terminal domain 1 BLYB PF05289.11 ETO08926.1 - 0.069 13.4 3.6 0.54 10.5 0.1 2.2 1 1 0 2 2 2 0 Borrelia hemolysin accessory protein Mob1_phocein PF03637.17 ETO08927.1 - 1.7e-30 106.2 2.3 3.2e-30 105.4 2.3 1.4 1 0 0 1 1 1 1 Mob1/phocein family CLASP_N PF12348.8 ETO08927.1 - 0.015 14.9 0.8 0.022 14.3 0.8 1.5 1 1 0 1 1 1 0 CLASP N terminal Kelch_5 PF13854.6 ETO08928.1 - 9.2e-06 25.5 0.5 1.4 9.0 0.0 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO08928.1 - 0.0037 17.2 3.5 25 5.0 0.0 5.1 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO08928.1 - 0.0039 17.4 6.8 10 6.6 0.0 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 ETO08928.1 - 0.017 14.7 0.7 2.4 7.8 0.0 3.7 4 0 0 4 4 4 0 Kelch motif LPD25 PF18840.1 ETO08928.1 - 0.017 15.7 0.9 0.049 14.2 0.9 1.7 1 0 0 1 1 1 0 Large polyvalent protein associated domain 25 Kelch_4 PF13418.6 ETO08928.1 - 0.07 13.2 2.8 0.11 12.6 0.1 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain FIVAR PF07554.13 ETO08929.1 - 0.17 12.7 0.6 0.17 12.7 0.6 2.0 2 0 0 2 2 2 0 FIVAR domain RIFIN PF02009.16 ETO08930.1 - 0.0078 16.1 2.7 0.0078 16.1 2.7 3.1 1 1 2 3 3 3 1 Rifin Claudin_2 PF13903.6 ETO08930.1 - 0.069 12.9 0.0 0.069 12.9 0.0 2.0 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DHHC PF01529.20 ETO08930.1 - 0.35 11.0 8.5 0.31 11.2 5.3 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Phage_Gp23 PF10669.9 ETO08930.1 - 1.1 9.6 0.0 1.1 9.6 0.0 3.9 2 1 2 4 4 4 0 Protein gp23 (Bacteriophage A118) Med13_C PF06333.12 ETO08931.1 - 0.026 13.8 1.1 0.04 13.2 1.1 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Holin_BhlA PF10960.8 ETO08931.1 - 0.23 11.4 2.2 0.46 10.5 0.8 2.1 1 1 1 2 2 2 0 BhlA holin family SR-25 PF10500.9 ETO08932.1 - 0.0025 17.5 28.5 0.0031 17.1 28.5 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 ETO08932.1 - 1.3 7.5 28.9 1.6 7.2 28.9 1.0 1 0 0 1 1 1 0 Utp14 protein DUF853 PF05872.12 ETO08932.1 - 3.2 6.2 7.8 4 5.9 7.8 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) PI3_PI4_kinase PF00454.27 ETO08933.1 - 2.3e-22 80.0 0.1 3e-22 79.6 0.1 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 ETO08933.1 - 0.066 12.5 0.0 0.093 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) FKBP_C PF00254.28 ETO08934.1 - 3.1e-13 49.9 0.0 5e-13 49.2 0.0 1.3 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase FKBP_N PF01346.18 ETO08934.1 - 4e-07 30.9 0.0 7.8e-07 30.0 0.0 1.4 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase RITA PF17066.5 ETO08935.1 - 0.074 12.6 0.0 0.093 12.3 0.0 1.1 1 0 0 1 1 1 0 RBPJ-interacting and tubulin associated protein GFO_IDH_MocA PF01408.22 ETO08936.1 - 4.8e-18 66.1 0.1 1.2e-17 64.8 0.0 1.6 2 0 0 2 2 2 1 Oxidoreductase family, NAD-binding Rossmann fold NAD_binding_3 PF03447.16 ETO08936.1 - 6.1e-06 26.9 0.2 2.1e-05 25.2 0.1 1.9 1 1 0 2 2 2 1 Homoserine dehydrogenase, NAD binding domain GFO_IDH_MocA_C PF02894.17 ETO08936.1 - 2.1e-05 24.5 0.0 5.2e-05 23.2 0.0 1.7 1 1 0 1 1 1 1 Oxidoreductase family, C-terminal alpha/beta domain F420_oxidored PF03807.17 ETO08936.1 - 2.7e-05 24.7 0.0 5.7e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Shikimate_DH PF01488.20 ETO08936.1 - 0.005 16.9 0.0 0.011 15.7 0.0 1.6 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ETO08936.1 - 0.042 14.1 0.1 0.1 12.9 0.0 1.8 1 1 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain Hydrolase PF00702.26 ETO08936.1 - 0.14 12.4 0.1 0.27 11.5 0.1 1.4 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ADH_zinc_N PF00107.26 ETO08936.1 - 0.16 12.0 0.7 0.42 10.6 0.3 2.0 2 1 0 2 2 2 0 Zinc-binding dehydrogenase COesterase PF00135.28 ETO08937.1 - 0.18 10.6 0.4 0.2 10.5 0.4 1.0 1 0 0 1 1 1 0 Carboxylesterase family Pex14_N PF04695.13 ETO08939.1 - 0.055 14.1 1.1 0.067 13.8 0.5 1.5 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region zf-C2H2 PF00096.26 ETO08940.1 - 3.4e-06 27.2 18.1 0.00018 21.8 1.8 3.8 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO08940.1 - 0.0037 18.0 17.6 0.046 14.6 1.9 3.9 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_12 PF18658.1 ETO08940.1 - 0.02 14.5 3.3 0.54 9.9 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger C2H2-type zf-H2C2_5 PF13909.6 ETO08940.1 - 0.079 12.7 0.8 0.079 12.7 0.8 3.7 3 0 0 3 3 3 0 C2H2-type zinc-finger domain FOXP-CC PF16159.5 ETO08940.1 - 0.42 11.3 12.5 0.48 11.1 1.1 3.1 3 0 0 3 3 3 0 FOXP coiled-coil domain eIF3_p135 PF12807.7 ETO08940.1 - 1.8 8.6 8.6 9.7 6.2 0.8 2.4 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 zf-C2H2_11 PF16622.5 ETO08940.1 - 1.9 8.3 6.0 1.9 8.3 0.5 2.6 2 0 0 2 2 2 0 zinc-finger C2H2-type LigB PF02900.18 ETO08942.1 - 0.0043 16.2 0.0 0.0052 15.9 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Kelch_6 PF13964.6 ETO08943.1 - 0.00034 20.8 0.2 0.0085 16.4 0.0 2.3 2 1 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO08943.1 - 0.0051 16.8 0.0 0.049 13.7 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain UPF1_Zn_bind PF09416.10 ETO08944.1 - 1.6e-11 44.4 8.9 3.9e-11 43.1 8.9 1.7 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) Kelch_6 PF13964.6 ETO08945.1 - 3.7e-05 23.8 2.5 0.36 11.2 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO08945.1 - 0.00015 21.7 0.1 0.027 14.5 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO08945.1 - 0.00017 21.1 2.6 0.00059 19.4 0.1 3.2 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO08945.1 - 0.00069 19.8 1.7 0.02 15.2 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08945.1 - 0.001 19.0 0.7 17 5.5 0.0 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO08945.1 - 0.0038 17.1 7.4 0.015 15.3 0.1 4.3 4 1 0 4 4 4 1 Kelch motif Dicty_REP PF05086.12 ETO08945.1 - 0.009 14.1 0.4 0.012 13.7 0.4 1.2 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein PQQ_3 PF13570.6 ETO08945.1 - 0.14 12.7 0.1 30 5.3 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain Vps35 PF03635.17 ETO08946.1 - 1.6e-192 641.9 26.7 6.5e-192 639.9 26.7 1.8 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 MOSC PF03473.17 ETO08947.1 - 7.8e-19 68.0 0.0 9.7e-19 67.7 0.0 1.1 1 0 0 1 1 1 1 MOSC domain GRIP PF01465.20 ETO08948.1 - 2e-08 34.0 0.1 5.2e-08 32.7 0.1 1.8 1 0 0 1 1 1 1 GRIP domain BT1 PF03092.16 ETO08948.1 - 0.019 13.2 0.3 0.019 13.2 0.3 1.6 2 0 0 2 2 2 0 BT1 family SDA1 PF05285.12 ETO08949.1 - 0.037 13.5 21.6 0.039 13.4 21.6 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO08949.1 - 1.7 6.7 23.8 1.9 6.6 23.8 1.0 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 ETO08949.1 - 1.8 7.5 7.5 2.1 7.3 7.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Adaptin_binding PF10199.9 ETO08949.1 - 2.7 8.6 19.5 3.8 8.1 19.5 1.2 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Fmp27 PF10344.9 ETO08949.1 - 2.9 5.9 10.2 3 5.8 10.2 1.2 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 BUD22 PF09073.10 ETO08949.1 - 4.3 6.6 17.0 4.7 6.5 17.0 1.2 1 0 0 1 1 1 0 BUD22 MscS_TM PF12794.7 ETO08949.1 - 6.1 5.6 7.3 7.4 5.3 7.3 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TRAP_alpha PF03896.16 ETO08949.1 - 7.1 5.8 14.8 8.6 5.5 14.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Abhydrolase_2 PF02230.16 ETO08950.1 - 2e-15 57.2 0.0 1.1e-14 54.7 0.0 1.8 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 ETO08950.1 - 0.0007 19.1 0.0 0.00098 18.7 0.0 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ETO08950.1 - 0.0011 18.6 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Dienelactone hydrolase family Hydrolase_4 PF12146.8 ETO08950.1 - 0.0041 16.4 0.1 0.066 12.5 0.0 2.0 1 1 1 2 2 2 1 Serine aminopeptidase, S33 FSH1 PF03959.13 ETO08950.1 - 0.035 13.8 0.0 0.049 13.3 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) DHHC PF01529.20 ETO08950.1 - 2.6 8.1 7.1 4.3 7.4 7.1 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase Aldedh PF00171.22 ETO08951.1 - 3.9e-122 408.1 1.1 1.8e-107 359.7 0.5 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family AAA PF00004.29 ETO08952.1 - 9.3e-18 64.9 0.0 1.9e-17 63.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO08952.1 - 2.7e-05 23.9 0.0 0.0051 16.6 0.0 2.8 3 0 0 3 3 3 2 AAA+ lid domain Vps4_C PF09336.10 ETO08952.1 - 0.0067 16.4 0.0 0.017 15.1 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain G-alpha PF00503.20 ETO08953.1 - 4.3e-65 220.2 3.3 5.7e-65 219.8 3.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO08953.1 - 6.1e-06 25.8 0.8 0.049 13.1 0.0 3.1 3 0 0 3 3 3 2 ADP-ribosylation factor family AAA_14 PF13173.6 ETO08953.1 - 0.077 13.0 1.1 0.46 10.5 0.4 2.8 3 1 0 3 3 3 0 AAA domain Ras PF00071.22 ETO08956.1 - 0.0084 15.7 0.6 0.62 9.6 0.1 2.4 1 1 1 2 2 2 2 Ras family STPPase_N PF16891.5 ETO08956.1 - 0.013 16.0 1.5 0.072 13.5 0.2 2.5 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain Myco_arth_vir_N PF09610.10 ETO08956.1 - 8.9 6.5 8.6 1 9.5 1.7 2.6 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) SF-assemblin PF06705.11 ETO08957.1 - 0.017 14.5 0.4 0.019 14.3 0.4 1.1 1 0 0 1 1 1 0 SF-assemblin/beta giardin RVT_1 PF00078.27 ETO08960.1 - 2.9e-17 63.0 0.1 6.7e-17 61.7 0.0 1.6 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Erf4 PF10256.9 ETO08960.1 - 0.2 11.8 2.2 1.4 9.0 0.1 2.8 2 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family HSP90 PF00183.18 ETO08961.1 - 3.4e-89 300.1 45.1 1.2e-79 268.6 23.3 3.5 2 1 1 3 3 3 2 Hsp90 protein HATPase_c PF02518.26 ETO08961.1 - 2.6e-10 40.8 0.0 6.9e-10 39.4 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase BAH PF01426.18 ETO08963.1 - 0.039 13.8 0.7 0.59 10.0 0.1 2.6 2 0 0 2 2 2 0 BAH domain Piwi PF02171.17 ETO08963.1 - 0.091 12.0 2.1 0.18 11.0 1.6 1.8 1 1 1 2 2 2 0 Piwi domain Atrophin-1 PF03154.15 ETO08963.1 - 0.15 10.4 14.7 0.21 9.9 14.3 1.3 1 1 0 1 1 1 0 Atrophin-1 family WD40 PF00400.32 ETO08964.1 - 7.8e-30 102.5 1.7 1.1e-11 45.1 0.0 3.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08964.1 - 7.8e-10 38.9 0.1 0.00025 21.3 0.0 3.2 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO08964.1 - 0.00046 20.1 0.0 0.021 14.7 0.1 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO08964.1 - 0.00094 18.6 0.1 0.0018 17.7 0.1 1.6 1 1 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETO08964.1 - 0.0012 17.9 0.0 1.1 8.2 0.0 2.9 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5071 PF16804.5 ETO08964.1 - 0.086 13.1 0.0 0.13 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5071) DUF866 PF05907.13 ETO08964.1 - 0.093 12.6 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF866) Pkinase PF00069.25 ETO08965.1 - 4.6e-23 81.9 6.4 1.6e-14 53.9 5.3 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO08965.1 - 0.00041 19.7 0.1 0.077 12.3 0.1 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ETO08965.1 - 0.0026 17.7 0.0 0.051 13.5 0.0 2.1 1 1 0 2 2 2 1 Phosphotransferase enzyme family IPPT PF01715.17 ETO08965.1 - 0.0049 16.7 0.6 0.0066 16.3 0.6 1.2 1 0 0 1 1 1 1 IPP transferase Raptor_N PF14538.6 ETO08965.1 - 0.011 15.7 0.1 0.022 14.7 0.1 1.4 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain Pkinase_fungal PF17667.1 ETO08965.1 - 0.058 12.2 0.0 0.075 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF3480 PF11979.8 ETO08965.1 - 0.28 10.1 2.6 0.44 9.5 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3480) Exo_endo_phos_2 PF14529.6 ETO08966.1 - 7.2e-18 64.6 1.1 8.5e-18 64.3 1.1 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO08966.1 - 0.059 12.9 0.0 0.082 12.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 ETO08967.1 - 0.1 13.5 0.3 0.21 12.5 0.3 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat DMA PF03474.14 ETO08968.1 - 0.044 13.4 0.1 0.092 12.4 0.1 1.6 1 0 0 1 1 1 0 DMRTA motif PPR PF01535.20 ETO08968.1 - 0.046 14.0 0.2 0.11 12.8 0.2 1.7 1 0 0 1 1 1 0 PPR repeat PPR_1 PF12854.7 ETO08968.1 - 0.055 13.2 0.1 0.1 12.4 0.1 1.5 1 0 0 1 1 1 0 PPR repeat 4PPT_N PF17837.1 ETO08968.1 - 0.095 12.8 0.0 0.45 10.7 0.0 1.8 2 0 0 2 2 2 0 4'-phosphopantetheinyl transferase N-terminal domain WD40 PF00400.32 ETO08969.1 - 3.9e-11 43.3 5.7 7.4e-08 32.9 0.9 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08969.1 - 0.00063 20.0 0.0 0.0012 19.1 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO08969.1 - 0.0036 16.9 1.6 0.0038 16.8 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) ArfGap PF01412.18 ETO08971.1 - 6.1e-39 132.7 1.2 6.1e-39 132.7 1.2 2.9 2 2 1 3 3 3 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 ETO08971.1 - 0.19 11.9 0.8 0.4 10.9 0.8 1.5 1 0 0 1 1 1 0 B-box zinc finger SOBP PF15279.6 ETO08971.1 - 0.31 11.6 10.3 0.46 11.0 10.3 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF3987 PF13148.6 ETO08971.1 - 0.82 8.6 6.2 1.3 7.9 6.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Glyco_transf_92 PF01697.27 ETO08972.1 - 2.2e-13 50.5 7.4 2.2e-13 50.5 7.4 2.0 2 0 0 2 2 2 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO08972.1 - 1.3e-07 32.1 1.3 3.5e-06 27.4 0.5 3.0 2 1 1 3 3 3 1 Glycosyl transferase family 2 Vut_1 PF02592.15 ETO08972.1 - 0.022 15.1 0.0 0.066 13.5 0.0 1.8 1 0 0 1 1 1 0 Putative vitamin uptake transporter PBP1_TM PF14812.6 ETO08973.1 - 0.0011 19.3 4.1 0.0011 19.3 4.1 2.2 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 ETO08973.1 - 0.027 13.7 1.8 0.031 13.5 1.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SPOUT_MTase PF02590.17 ETO08973.1 - 0.03 14.3 0.7 0.03 14.3 0.7 2.1 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase RNA_replicase_B PF03431.13 ETO08973.1 - 0.051 12.0 0.6 0.062 11.8 0.6 1.1 1 0 0 1 1 1 0 RNA replicase, beta-chain DUF913 PF06025.12 ETO08973.1 - 0.1 11.5 2.7 0.11 11.4 2.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Serinc PF03348.15 ETO08973.1 - 1.9 7.3 6.5 1.1 8.1 5.0 1.3 1 1 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 ETO08973.1 - 3.9 6.2 8.0 4.6 5.9 8.0 1.2 1 0 0 1 1 1 0 Presenilin TRAP_alpha PF03896.16 ETO08973.1 - 7 5.8 7.5 0.18 11.0 0.9 1.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit RRM_1 PF00076.22 ETO08974.1 - 0.00012 21.9 0.0 0.00025 20.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Macoilin PF09726.9 ETO08974.1 - 0.069 11.7 12.4 0.091 11.3 12.4 1.2 1 0 0 1 1 1 0 Macoilin family Velvet PF11754.8 ETO08974.1 - 3.1 7.7 12.1 26 4.6 0.0 2.3 2 0 0 2 2 2 0 Velvet factor RR_TM4-6 PF06459.12 ETO08975.1 - 0.12 12.2 17.2 0.14 11.9 17.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 ETO08975.1 - 0.89 9.5 16.2 1.1 9.2 16.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Striatin PF08232.12 ETO08975.1 - 1.2 9.7 17.0 1.6 9.3 17.0 1.3 1 0 0 1 1 1 0 Striatin family SAPS PF04499.15 ETO08975.1 - 1.8 7.2 21.0 2 7.1 21.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 ETO08975.1 - 2.4 6.9 23.0 2.4 6.8 23.0 1.0 1 0 0 1 1 1 0 Presenilin Gti1_Pac2 PF09729.9 ETO08975.1 - 2.7 8.1 19.0 3.6 7.7 19.0 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family DUF3807 PF12720.7 ETO08975.1 - 2.8 8.2 21.1 3.3 7.9 21.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Nop14 PF04147.12 ETO08975.1 - 3.2 5.8 23.4 3.4 5.8 23.4 1.0 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO08975.1 - 3.3 6.4 21.8 3.7 6.2 21.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pannexin_like PF12534.8 ETO08975.1 - 4.3 6.3 11.5 5 6.1 11.5 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CDC45 PF02724.14 ETO08975.1 - 4.9 5.3 20.5 5.2 5.2 20.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO08975.1 - 5.2 6.2 16.1 5.8 6.0 16.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MAJIN PF15077.6 ETO08975.1 - 7.5 6.3 12.4 8.2 6.1 12.4 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein CLN3 PF02487.17 ETO08975.1 - 8 5.4 9.3 9.3 5.2 9.3 1.3 1 0 0 1 1 1 0 CLN3 protein Actin PF00022.19 ETO08976.1 - 1e-58 198.9 0.0 2e-58 198.0 0.0 1.4 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO08976.1 - 0.053 12.3 0.0 0.054 12.3 0.0 1.3 1 1 0 1 1 1 0 MreB/Mbl protein DUF4223 PF13978.6 ETO08977.1 - 0.042 13.8 0.1 0.042 13.8 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4223) DUF3586 PF12131.8 ETO08977.1 - 0.051 13.8 8.8 0.21 11.8 2.8 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3586) WD40 PF00400.32 ETO08978.1 - 1.9e-11 44.3 9.9 1e-05 26.2 0.8 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO08978.1 - 8.5e-07 28.0 0.9 0.0043 15.8 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO08978.1 - 8e-06 25.4 2.2 9.4e-05 21.9 0.7 1.9 1 1 1 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO08978.1 - 0.00014 22.1 0.5 0.0021 18.3 0.0 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_S9_N PF02897.15 ETO08978.1 - 0.0031 16.4 0.6 0.0037 16.1 0.6 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Nucleoporin_N PF08801.11 ETO08978.1 - 0.0036 16.1 1.8 0.035 12.9 1.7 1.9 1 1 1 2 2 2 1 Nup133 N terminal like W_rich_C PF07483.11 ETO08978.1 - 0.063 13.4 3.4 0.22 11.7 0.2 2.1 1 1 1 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain ArlS_N PF18719.1 ETO08978.1 - 0.1 12.8 4.9 2.8 8.2 2.7 2.0 1 1 1 2 2 2 0 ArlS sensor domain C2 PF00168.30 ETO08979.1 - 8.1e-07 29.3 0.2 3.9e-06 27.1 0.1 2.0 2 0 0 2 2 2 1 C2 domain U3_snoRNA_assoc PF08297.11 ETO08979.1 - 0.7 10.6 13.0 2.4 8.9 7.9 2.5 2 0 0 2 2 2 0 U3 snoRNA associated Kelch_1 PF01344.25 ETO08980.1 - 1.9e-13 49.7 0.7 2.3e-05 23.9 0.1 5.1 5 1 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ETO08980.1 - 2.5e-11 43.4 5.3 0.0091 16.3 0.1 5.3 4 1 1 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ETO08980.1 - 1.1e-10 41.5 0.9 0.00063 20.0 0.1 5.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO08980.1 - 1.5e-09 37.6 4.1 0.00044 20.2 0.0 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO08980.1 - 9.6e-07 28.5 1.4 2.2 8.4 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO08980.1 - 0.0001 22.2 0.2 0.78 9.8 0.0 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain OATP PF03137.20 ETO08981.1 - 0.00016 20.1 0.4 0.00023 19.6 0.4 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family CD34_antigen PF06365.12 ETO08981.1 - 0.00097 18.8 0.2 0.0018 17.9 0.2 1.4 1 0 0 1 1 1 1 CD34/Podocalyxin family DcuC PF03606.15 ETO08981.1 - 0.0014 17.2 2.7 0.002 16.7 2.7 1.1 1 0 0 1 1 1 1 C4-dicarboxylate anaerobic carrier TMEM154 PF15102.6 ETO08981.1 - 0.0033 17.3 1.4 0.0073 16.2 0.6 2.0 1 1 1 2 2 2 1 TMEM154 protein family MFS_1 PF07690.16 ETO08981.1 - 0.0044 16.0 0.0 0.0063 15.5 0.0 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF898 PF05987.13 ETO08981.1 - 0.0047 16.0 0.5 0.0056 15.8 0.5 1.2 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) TMEM51 PF15345.6 ETO08981.1 - 0.0078 16.1 0.2 0.014 15.2 0.2 1.3 1 0 0 1 1 1 1 Transmembrane protein 51 BatD PF13584.6 ETO08981.1 - 0.022 13.6 0.1 0.03 13.1 0.1 1.2 1 0 0 1 1 1 0 Oxygen tolerance PRIMA1 PF16101.5 ETO08981.1 - 0.11 12.5 0.4 0.11 12.5 0.4 1.8 1 1 1 2 2 2 0 Proline-rich membrane anchor 1 RsfS PF02410.15 ETO08981.1 - 0.2 12.1 1.8 1 9.8 0.7 2.3 2 1 0 2 2 2 0 Ribosomal silencing factor during starvation Orf78 PF06024.12 ETO08981.1 - 0.58 10.5 10.8 1.7 9.0 0.6 2.6 1 1 1 2 2 2 0 Orf78 (ac78) Lig_chan PF00060.26 ETO08981.1 - 1.3 8.8 4.6 0.34 10.7 0.2 2.3 2 1 0 2 2 2 0 Ligand-gated ion channel SRTM1 PF15872.5 ETO08981.1 - 2 8.6 9.2 0.18 12.0 0.7 2.6 2 1 1 3 3 3 0 Serine-rich and transmembrane domain-containing protein 1 G-alpha PF00503.20 ETO08982.1 - 1.5e-28 100.0 0.7 1.8e-28 99.7 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit AAA_7 PF12775.7 ETO08982.1 - 0.01 15.4 0.1 0.015 14.8 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Arf PF00025.21 ETO08982.1 - 0.034 13.6 0.1 0.054 12.9 0.1 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family ABC_tran PF00005.27 ETO08982.1 - 0.035 14.6 0.2 0.1 13.1 0.1 1.8 1 1 0 1 1 1 0 ABC transporter DUF5392 PF17370.2 ETO08982.1 - 0.076 13.1 1.4 0.14 12.3 1.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5392) AAA_29 PF13555.6 ETO08982.1 - 0.095 12.5 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Molybdopterin PF00384.22 ETO08983.1 - 1.4e-53 182.4 0.0 4.9e-28 98.3 0.0 2.1 1 1 1 2 2 2 2 Molybdopterin oxidoreductase WD40 PF00400.32 ETO08985.1 - 1e-21 76.8 14.2 2.5e-05 25.0 0.5 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO08985.1 - 1.6e-08 34.8 1.1 0.023 15.0 0.0 4.4 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO08985.1 - 2.2e-06 26.6 3.9 0.00067 18.4 0.0 3.4 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Sec16 PF12932.7 ETO08985.1 - 0.064 13.9 0.1 0.15 12.6 0.1 1.6 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region Myb_DNA-bind_3 PF12776.7 ETO08986.1 - 0.046 14.7 0.3 0.089 13.8 0.3 1.4 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain WD40 PF00400.32 ETO08987.1 - 3.6e-10 40.3 7.3 1e-06 29.3 1.8 3.6 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO08987.1 - 0.0051 15.5 1.4 1.2 7.7 0.2 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF1030 PF06270.11 ETO08987.1 - 0.075 12.8 4.2 0.11 12.3 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1030) Lipase PF00151.19 ETO08990.1 - 1.2 8.4 5.0 3.4 6.9 0.8 2.2 2 0 0 2 2 2 0 Lipase HAP1_N PF04849.13 ETO08992.1 - 0.0023 17.2 4.0 0.003 16.8 4.0 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Csm1_N PF18504.1 ETO08992.1 - 0.035 14.4 7.0 0.035 14.4 7.0 2.6 2 1 1 3 3 3 0 Csm1 N-terminal domain HIP1_clath_bdg PF16515.5 ETO08992.1 - 0.068 13.8 3.6 0.14 12.8 3.6 1.6 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2947 PF11163.8 ETO08992.1 - 1.8 8.4 7.2 1.5 8.7 2.5 2.6 1 1 3 4 4 4 0 Protein of unknown function (DUF2947) FUSC PF04632.12 ETO08995.1 - 1.2 7.6 4.1 1.5 7.2 4.1 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family CEP63 PF17045.5 ETO08995.1 - 6.1 6.7 45.4 3.5 7.5 15.1 2.1 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa TORC_M PF12885.7 ETO08996.1 - 0.013 15.4 7.1 0.018 15.0 7.1 1.2 1 0 0 1 1 1 0 Transducer of regulated CREB activity middle domain Vfa1 PF08432.10 ETO08996.1 - 0.13 12.5 24.0 0.21 11.9 24.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 ETO08996.1 - 1.1 7.5 20.2 1.2 7.4 20.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 ETO08996.1 - 1.3 7.5 13.2 1.4 7.5 13.2 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Nop14 PF04147.12 ETO08996.1 - 1.5 7.0 23.0 1.6 6.8 23.0 1.1 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO08996.1 - 3.9 6.2 23.7 5.7 5.6 23.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Dapper PF15268.6 ETO08996.1 - 4.1 6.1 16.9 4.7 5.9 16.9 1.0 1 0 0 1 1 1 0 Dapper SLC12 PF03522.15 ETO08996.1 - 4.2 6.3 19.3 4.8 6.1 19.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF913 PF06025.12 ETO08996.1 - 4.6 6.1 10.6 5.4 5.9 10.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CobT PF06213.12 ETO08996.1 - 6.8 6.0 17.4 7.8 5.8 17.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT zf-C2H2_4 PF13894.6 ETO08997.1 - 2.9e-10 40.1 36.1 0.0011 19.6 1.0 6.7 7 0 0 7 7 6 4 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO08997.1 - 3.9e-07 30.2 40.0 0.0038 17.6 1.4 6.5 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-C2H2_8 PF15909.5 ETO08997.1 - 1.7e-05 25.0 7.0 1.7e-05 25.0 7.0 2.5 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-H2C2_2 PF13465.6 ETO08997.1 - 0.00027 21.2 1.9 0.00027 21.2 1.9 6.0 6 2 0 6 6 6 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ETO08997.1 - 0.00038 20.7 26.7 0.0079 16.5 1.0 6.1 7 0 0 7 7 7 2 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 ETO08997.1 - 0.00087 18.8 7.3 1.5 8.5 0.1 4.7 4 0 0 4 4 4 2 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 ETO08997.1 - 0.0016 18.4 32.4 0.026 14.5 0.9 5.7 6 0 0 6 6 5 4 C2H2-type zinc finger zf-met PF12874.7 ETO08997.1 - 0.11 12.9 0.3 0.11 12.9 0.3 6.1 7 0 0 7 7 7 0 Zinc-finger of C2H2 type zf-BED PF02892.15 ETO08997.1 - 0.19 11.8 22.2 0.31 11.1 3.6 4.0 1 1 2 3 3 3 0 BED zinc finger zf-RRN7 PF11781.8 ETO08997.1 - 5.5 6.8 12.5 22 4.8 0.2 4.4 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 zinc_ribbon_9 PF14369.6 ETO08997.1 - 8.1 6.8 11.8 28 5.1 0.1 4.2 4 0 0 4 4 4 0 zinc-ribbon DAO PF01266.24 ETO08998.1 - 1.9e-29 103.4 0.0 1.8e-28 100.2 0.0 2.3 1 1 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO08998.1 - 0.0071 15.6 0.0 0.14 11.4 0.0 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETO08998.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Thi4 family PIP5K PF01504.18 ETO08999.1 - 1.2e-25 90.3 0.0 1.8e-25 89.7 0.0 1.3 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PIP5K PF01504.18 ETO09000.1 - 2.2e-12 46.8 1.5 4.1e-10 39.3 0.0 2.2 1 1 1 2 2 2 2 Phosphatidylinositol-4-phosphate 5-Kinase Pkinase PF00069.25 ETO09001.1 - 9.4e-41 139.9 0.0 1.8e-40 139.0 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09001.1 - 6.6e-30 104.2 0.0 8.2e-30 103.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO09001.1 - 2.2e-05 24.0 0.0 5e-05 22.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Pox_ser-thr_kin PF05445.11 ETO09001.1 - 0.012 14.6 0.0 0.019 14.0 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase APH PF01636.23 ETO09001.1 - 0.016 15.2 0.0 0.029 14.3 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ETO09001.1 - 0.016 14.3 0.0 0.044 12.8 0.0 1.7 2 0 0 2 2 2 0 Seadornavirus VP7 WD40 PF00400.32 ETO09004.1 - 2.1e-05 25.2 8.8 2.7e-05 24.8 0.7 3.5 3 2 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 ETO09007.1 - 6.1e-11 42.7 8.3 4.7e-08 33.6 2.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO09007.1 - 3.9e-05 23.1 1.1 6.9e-05 22.3 1.1 1.4 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO09007.1 - 0.0016 17.1 0.6 0.0028 16.4 0.1 1.6 2 0 0 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09007.1 - 0.0027 18.0 0.0 0.0057 16.9 0.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain TraP PF07296.11 ETO09007.1 - 0.097 11.8 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 TraP protein RhoGAP PF00620.27 ETO09008.1 - 3.5e-30 104.8 0.2 8.9e-30 103.5 0.0 1.7 2 0 0 2 2 2 1 RhoGAP domain NACHT PF05729.12 ETO09010.1 - 2.4e-07 30.8 0.0 5.6e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO09010.1 - 5.5e-06 25.8 0.4 1.5e-05 24.3 0.4 1.7 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO09010.1 - 2.5e-05 24.6 0.0 6.5e-05 23.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain DUF3038 PF11237.8 ETO09010.1 - 0.0046 17.0 0.4 0.017 15.2 0.1 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF3038) AAA_18 PF13238.6 ETO09010.1 - 0.015 15.9 1.3 0.098 13.2 0.3 2.9 2 1 0 2 2 2 0 AAA domain WD40 PF00400.32 ETO09011.1 - 1.1e-67 222.3 20.7 1.1e-08 35.6 0.1 8.5 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09011.1 - 2.9e-15 56.3 2.7 0.001 19.3 0.1 5.2 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09011.1 - 8e-11 41.8 12.8 0.00047 19.6 0.1 4.9 3 3 2 5 5 5 4 WD40-like domain Pentapeptide PF00805.22 ETO09011.1 - 1.4e-07 31.0 1.7 2.9e-07 30.0 1.7 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Ge1_WD40 PF16529.5 ETO09011.1 - 4e-07 29.3 1.7 0.1 11.5 0.0 4.8 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO09011.1 - 1.9e-06 26.8 11.5 0.7 8.5 0.0 7.0 3 2 5 8 8 8 4 Nucleoporin Nup120/160 Pentapeptide_4 PF13599.6 ETO09011.1 - 3.9e-06 26.9 0.2 1.2e-05 25.4 0.2 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF727 PF05303.12 ETO09011.1 - 0.00024 21.1 0.7 8.6 6.5 0.0 5.4 3 2 2 5 5 5 1 Protein of unknown function (DUF727) Cytochrom_D1 PF02239.16 ETO09011.1 - 0.005 15.4 4.2 1.4 7.4 0.2 3.2 2 1 1 3 3 3 2 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO09011.1 - 0.007 16.5 0.3 0.007 16.5 0.3 1.9 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Gmad1 PF10647.9 ETO09011.1 - 0.02 14.7 0.0 0.35 10.6 0.0 2.6 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain POLO_box PF00659.18 ETO09011.1 - 0.92 9.8 4.0 1.6 9.0 0.1 3.5 4 1 1 5 5 5 0 POLO box duplicated region WD40 PF00400.32 ETO09012.1 - 3.4e-20 72.0 5.8 4.2e-08 33.7 0.0 4.2 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09012.1 - 6e-05 23.3 0.0 2.7 8.3 0.0 3.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09012.1 - 0.0048 15.6 0.6 0.28 9.8 0.0 2.8 1 1 2 3 3 3 1 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO09012.1 - 0.023 13.6 1.5 0.48 9.3 0.0 2.7 1 1 2 3 3 3 0 Partner and localizer of BRCA2 WD40 domain CAP_GLY PF01302.25 ETO09013.1 - 0.0027 17.7 0.3 4.8 7.3 0.1 3.0 2 1 1 3 3 3 2 CAP-Gly domain AAA_9 PF12781.7 ETO09014.1 - 3e-05 23.3 0.4 7.7e-05 21.9 0.0 1.9 2 0 0 2 2 2 1 ATP-binding dynein motor region Peroxin-22 PF12827.7 ETO09014.1 - 0.063 13.2 0.1 0.17 11.8 0.1 1.9 1 1 0 1 1 1 0 Peroxisomal biogenesis protein family WD40 PF00400.32 ETO09015.1 - 4.7e-22 77.9 5.7 1.3e-07 32.2 0.1 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO09015.1 - 9.9e-07 28.0 0.0 0.0035 16.4 0.0 2.8 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO09015.1 - 1.6e-06 28.3 0.1 0.035 14.4 0.0 2.4 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO09015.1 - 7e-05 22.6 0.8 5.1 7.2 0.0 3.5 3 0 0 3 3 3 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO09015.1 - 0.00045 19.0 1.5 0.058 12.0 0.2 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO09015.1 - 0.0094 14.7 0.5 0.3 9.8 0.1 2.3 2 0 0 2 2 2 1 Nup133 N terminal like Nbas_N PF15492.6 ETO09015.1 - 0.011 15.1 0.1 3.2 7.0 0.0 2.7 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF3123 PF11321.8 ETO09015.1 - 0.034 14.8 0.0 0.99 10.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) SGL PF08450.12 ETO09015.1 - 0.044 13.3 0.1 0.62 9.6 0.0 2.6 2 1 1 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Resistin PF06954.11 ETO09015.1 - 0.06 13.9 3.5 11 6.6 0.0 3.4 2 1 1 3 3 3 0 Resistin DUF5570 PF17731.1 ETO09015.1 - 0.075 13.1 4.0 3.8 7.6 0.0 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5570) Str_synth PF03088.16 ETO09015.1 - 0.087 13.0 0.0 1.4 9.1 0.0 2.8 1 1 1 2 2 2 0 Strictosidine synthase NACHT PF05729.12 ETO09016.1 - 2.5e-07 30.8 0.0 5.5e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO09016.1 - 0.0018 18.6 0.1 0.012 15.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO09016.1 - 0.0068 17.0 0.0 0.029 14.9 0.0 2.1 1 0 0 1 1 1 1 AAA domain ATP_bind_2 PF03668.15 ETO09016.1 - 0.043 13.1 0.1 0.14 11.5 0.0 1.8 2 0 0 2 2 2 0 P-loop ATPase protein family RNA_helicase PF00910.22 ETO09016.1 - 0.045 14.1 2.9 0.099 13.0 0.2 2.8 2 1 0 2 2 2 0 RNA helicase PAS_9 PF13426.7 ETO09016.1 - 0.058 13.6 0.6 7.9 6.8 0.0 3.1 2 1 0 2 2 2 0 PAS domain AAA_16 PF13191.6 ETO09016.1 - 0.062 13.7 0.0 1 9.7 0.0 2.4 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO09016.1 - 0.098 13.2 0.1 0.7 10.4 0.0 2.5 3 0 0 3 3 3 0 ABC transporter BRCT PF00533.26 ETO09017.1 - 0.083 13.3 0.5 0.083 13.3 0.5 1.9 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain DUF2098 PF09871.9 ETO09018.1 - 0.68 10.3 5.3 8.6 6.8 2.6 3.0 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) KapB PF08810.10 ETO09022.1 - 0.24 11.6 2.3 0.29 11.3 1.5 1.5 2 0 0 2 2 2 0 Kinase associated protein B WD40 PF00400.32 ETO09023.1 - 6.2e-17 61.7 14.4 0.0014 19.4 0.4 6.6 6 2 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO09023.1 - 0.0004 19.2 5.6 0.3 9.7 0.2 3.8 3 1 0 3 3 3 3 Nucleoporin Nup120/160 DUF432 PF04254.13 ETO09023.1 - 0.036 14.2 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF432) Mitofilin PF09731.9 ETO09024.1 - 0.0033 16.3 12.3 0.0053 15.7 12.3 1.3 1 0 0 1 1 1 1 Mitochondrial inner membrane protein HOIP-UBA PF16678.5 ETO09024.1 - 0.011 15.7 2.9 0.012 15.7 1.3 1.8 2 0 0 2 2 2 0 HOIP UBA domain pair T3SS_basalb_I PF17001.5 ETO09024.1 - 0.014 15.9 1.1 0.45 11.1 0.1 3.2 3 1 0 3 3 3 0 Type III secretion basal body protein I, YscI, HrpB, PscI DUF948 PF06103.11 ETO09024.1 - 0.044 14.0 10.3 0.88 9.9 0.6 4.1 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) COG5 PF10392.9 ETO09024.1 - 0.05 13.8 5.7 0.32 11.2 0.3 3.7 2 1 2 4 4 4 0 Golgi transport complex subunit 5 MitMem_reg PF13012.6 ETO09024.1 - 0.084 13.3 1.9 0.4 11.1 1.8 2.4 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function Scm3 PF10384.9 ETO09024.1 - 0.3 10.9 5.9 0.99 9.2 0.1 3.8 4 0 0 4 4 4 0 Centromere protein Scm3 CLZ PF16526.5 ETO09024.1 - 0.3 11.5 11.6 0.27 11.6 1.3 3.5 4 0 0 4 4 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Apolipoprotein PF01442.18 ETO09024.1 - 0.32 10.9 6.9 3.6 7.4 6.8 2.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain PIN_9 PF18477.1 ETO09024.1 - 0.35 11.2 3.3 0.56 10.5 0.1 2.8 2 1 1 3 3 3 0 PIN like domain SpmSyn_N PF17950.1 ETO09024.1 - 0.36 11.0 6.6 11 6.2 1.0 3.6 2 1 1 3 3 3 0 S-adenosylmethionine decarboxylase N -terminal DUF2935 PF11155.8 ETO09024.1 - 0.82 10.0 5.5 1.8 8.9 0.1 3.1 2 2 2 4 4 4 0 Domain of unknown function (DUF2935) GCP_C_terminal PF04130.13 ETO09024.1 - 1.7 8.0 8.2 10 5.4 0.0 3.1 2 1 0 3 3 3 0 Gamma tubulin complex component C-terminal Uds1 PF15456.6 ETO09024.1 - 2 8.6 11.4 0.82 9.8 3.8 3.1 3 0 0 3 3 3 0 Up-regulated During Septation Pup PF05639.11 ETO09024.1 - 3 8.8 8.0 1.4 9.9 1.0 3.0 3 0 0 3 3 2 0 Pup-like protein BORCS7 PF16088.5 ETO09024.1 - 3.2 8.1 9.6 21 5.5 0.1 3.8 3 1 0 3 3 3 0 BLOC-1-related complex sub-unit 7 DUF5601 PF18151.1 ETO09024.1 - 3.5 8.0 8.8 0.16 12.3 0.3 3.3 4 1 0 4 4 4 0 Domain of unknown function (DUF5601) DUF4140 PF13600.6 ETO09024.1 - 4.5 7.8 7.8 4.5 7.8 0.5 3.2 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Vps54 PF07928.12 ETO09024.1 - 5.4 7.5 6.0 3.3 8.1 0.3 3.1 3 1 1 4 4 4 0 Vps54-like protein SesA PF17107.5 ETO09024.1 - 5.9 7.1 11.7 4.8 7.4 1.8 3.7 3 2 1 4 4 4 0 N-terminal domain on NACHT_NTPase and P-loop NTPases zf-CRD PF17979.1 ETO09024.1 - 8.1 6.5 7.0 3.8 7.6 1.5 2.7 1 1 2 3 3 3 0 Cysteine rich domain with multizinc binding regions Baculo_PEP_C PF04513.12 ETO09025.1 - 0.54 10.3 7.4 25 4.9 0.2 3.7 3 2 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus GrpE PF01025.19 ETO09025.1 - 0.84 9.3 24.2 0.042 13.5 11.0 3.4 3 0 0 3 3 3 0 GrpE Lebercilin PF15619.6 ETO09025.1 - 1.9 8.1 38.1 0.55 9.9 10.0 3.7 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease OATP PF03137.20 ETO09026.1 - 0.044 12.1 2.1 1.1 7.5 0.5 2.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family YqzH PF14164.6 ETO09028.1 - 0.26 11.4 0.2 0.26 11.4 0.2 2.6 2 1 1 3 3 3 0 YqzH-like protein FtsX_ECD PF18075.1 ETO09028.1 - 0.59 10.8 3.7 5.8 7.6 3.3 2.1 1 1 1 2 2 2 0 FtsX extracellular domain WD40 PF00400.32 ETO09029.1 - 8.5e-05 23.3 7.2 0.00043 21.0 1.7 3.5 3 1 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO09029.1 - 0.12 11.0 0.5 1 7.9 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 YmzC PF14157.6 ETO09032.1 - 0.03 14.4 1.3 0.093 12.8 0.6 2.1 1 1 1 2 2 2 0 YmzC-like protein EAP30 PF04157.16 ETO09032.1 - 0.056 12.7 0.0 0.062 12.6 0.0 1.2 1 0 0 1 1 1 0 EAP30/Vps36 family Phage_X PF05155.15 ETO09032.1 - 0.08 13.4 0.1 2.9 8.4 0.0 2.3 1 1 0 2 2 2 0 Phage X family DUF1580 PF07618.11 ETO09033.1 - 0.013 15.1 0.0 0.038 13.6 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1580) LRR_4 PF12799.7 ETO09033.1 - 0.033 14.6 0.8 0.79 10.2 0.2 3.2 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) DUF2981 PF11200.8 ETO09034.1 - 6.7 6.4 9.6 9.6 5.8 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF3583 PF12126.8 ETO09035.1 - 0.02 14.4 7.1 0.029 13.8 4.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3583) DUF3106 PF11304.8 ETO09035.1 - 0.24 11.9 6.3 0.057 13.9 1.1 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3106) DUF87 PF01935.17 ETO09035.1 - 0.8 9.8 11.1 0.029 14.5 4.4 2.1 2 0 0 2 2 2 0 Helicase HerA, central domain DUF883 PF05957.13 ETO09035.1 - 7.5 7.2 6.4 2.1 9.0 2.5 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Pro_isomerase PF00160.21 ETO09036.1 - 1.2e-39 136.2 1.8 1.4e-39 135.9 0.0 2.1 2 0 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD RRM_1 PF00076.22 ETO09036.1 - 1.3e-14 53.8 0.0 4.6e-14 52.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NYD-SP28_assoc PF14775.6 ETO09037.1 - 0.14 12.3 3.1 1.2 9.3 0.2 3.4 3 0 0 3 3 3 0 Sperm tail C-terminal domain MecA PF05389.12 ETO09037.1 - 0.49 10.0 19.0 0.29 10.7 3.2 2.7 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) Folliculin PF11704.8 ETO09037.1 - 1.4 8.7 0.0 1.4 8.7 0.0 4.6 3 1 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport PPP4R2 PF09184.11 ETO09037.1 - 3.2 7.3 37.2 3.9 7.0 26.8 2.6 2 0 0 2 2 2 0 PPP4R2 CcmH PF03918.14 ETO09038.1 - 0.011 15.0 0.2 0.035 13.4 0.2 1.8 1 0 0 1 1 1 0 Cytochrome C biogenesis protein CENP-B_dimeris PF09026.10 ETO09038.1 - 8.7 6.8 8.5 17 5.9 6.8 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 ETO09039.1 - 0.0057 17.0 9.1 0.011 16.1 9.1 1.4 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF913 PF06025.12 ETO09039.1 - 0.0092 15.0 0.8 0.02 13.9 0.8 1.5 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Membr_traf_MHD PF10540.9 ETO09039.1 - 0.13 12.5 2.6 0.11 12.7 0.5 2.1 2 0 0 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain DALR_1 PF05746.15 ETO09039.1 - 0.13 12.4 1.6 0.36 11.0 1.6 1.8 1 0 0 1 1 1 0 DALR anticodon binding domain CENP-B_dimeris PF09026.10 ETO09039.1 - 0.31 11.5 6.2 0.66 10.4 6.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 ETO09039.1 - 0.5 10.1 8.8 0.96 9.2 8.8 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ETO09039.1 - 1.1 8.9 5.9 2.3 7.9 5.9 1.4 1 0 0 1 1 1 0 FAM176 family DUF4820 PF16091.5 ETO09039.1 - 1.3 8.3 5.0 2.6 7.4 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) WRNPLPNID PF15017.6 ETO09039.1 - 7.5 7.5 12.3 17 6.4 12.3 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box WD40 PF00400.32 ETO09040.1 - 8.3e-30 102.4 20.6 6.3e-07 30.0 1.2 6.8 6 1 0 6 6 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO09040.1 - 7e-07 28.3 9.7 0.0035 16.1 1.1 4.2 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09040.1 - 2.4e-06 27.7 2.2 0.065 13.5 0.0 5.1 4 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO09040.1 - 9.2e-05 23.1 0.9 0.0005 20.7 0.9 2.4 1 0 0 1 1 1 1 TRAF-type zinc finger Ycf70 PF17382.2 ETO09040.1 - 0.045 14.1 1.1 0.14 12.6 1.1 1.8 1 0 0 1 1 1 0 Uncharacterized Ycf70-like Flu_B_M2 PF04772.12 ETO09040.1 - 0.06 13.6 4.2 0.13 12.5 4.2 1.6 1 0 0 1 1 1 0 Influenza B matrix protein 2 (BM2) DUF2020 PF09449.10 ETO09040.1 - 0.083 12.7 0.0 1.5 8.7 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF2020) zf-C3HC4_3 PF13920.6 ETO09040.1 - 0.42 10.5 2.9 3.3 7.7 2.9 2.6 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FAM76 PF16046.5 ETO09040.1 - 1.5 8.1 14.6 5.8 6.2 14.6 1.9 1 1 0 1 1 1 0 FAM76 protein O-antigen_lig PF13425.6 ETO09040.1 - 2.4 6.9 11.6 3.9 6.2 11.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4047 PF13256.6 ETO09040.1 - 4.7 7.4 10.4 16 5.7 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) TPR_12 PF13424.6 ETO09041.1 - 7.6e-74 244.0 15.5 2.5e-20 72.5 0.3 4.6 2 1 4 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO09041.1 - 3.2e-54 179.4 0.0 6.6e-11 41.7 0.0 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09041.1 - 8.2e-40 131.9 1.9 4.5e-08 32.6 0.0 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09041.1 - 2.3e-34 115.8 37.2 1.9e-08 33.8 0.9 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09041.1 - 4.9e-28 95.0 37.2 1.9e-06 27.6 1.6 6.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09041.1 - 2.8e-27 92.6 23.6 6.5e-06 25.9 0.5 6.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO09041.1 - 1.5e-18 65.8 4.4 0.0013 19.0 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO09041.1 - 1.2e-11 45.1 0.0 0.11 13.1 0.0 5.0 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO09041.1 - 1e-09 38.4 3.8 0.0043 17.6 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO09041.1 - 9.6e-09 35.4 0.0 2.4 9.2 0.0 4.9 3 1 2 5 5 4 2 Tetratricopeptide repeat SNAP PF14938.6 ETO09041.1 - 2.4e-08 33.7 5.8 4.8e-06 26.2 1.7 3.3 2 1 1 3 3 3 1 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETO09041.1 - 1.1e-07 31.6 18.0 0.15 12.3 0.1 7.2 8 0 0 8 8 8 3 PPR repeat TPR_11 PF13414.6 ETO09041.1 - 2.5e-07 30.3 26.7 0.025 14.2 0.7 7.0 6 2 2 8 8 8 6 TPR repeat TPR_MalT PF17874.1 ETO09041.1 - 1.3e-06 28.0 0.0 6.7e-05 22.4 0.0 2.7 1 1 2 3 3 3 1 MalT-like TPR region DUF5113 PF17140.4 ETO09041.1 - 7.6e-06 25.8 19.1 0.12 12.2 0.2 5.9 5 1 1 6 6 6 3 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO09041.1 - 8.6e-05 23.0 2.1 0.35 11.4 0.2 3.9 2 1 2 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO09041.1 - 0.00051 20.0 25.0 0.15 12.1 0.1 6.6 7 0 0 7 7 7 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO09041.1 - 0.00071 19.8 14.0 1.8 8.8 0.2 5.4 2 2 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 HTH_Bact PF18768.1 ETO09041.1 - 0.0054 16.3 3.9 15 5.2 0.0 5.4 5 0 0 5 5 5 0 Helix-turn-helix bacterial domain Fis1_TPR_C PF14853.6 ETO09041.1 - 3.9 7.6 16.5 8.6 6.5 0.1 5.3 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat Meckelin PF09773.9 ETO09042.1 - 0.031 12.4 0.1 0.035 12.2 0.1 1.0 1 0 0 1 1 1 0 Meckelin (Transmembrane protein 67) Menin PF05053.13 ETO09044.1 - 2.3 6.5 10.5 0.22 9.9 2.7 2.1 2 0 0 2 2 2 0 Menin DUF818 PF05677.12 ETO09045.1 - 0.0018 17.3 0.0 0.0028 16.7 0.0 1.3 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) NACHT PF05729.12 ETO09046.1 - 2.1e-07 31.0 0.0 4.5e-07 29.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO09046.1 - 0.0002 21.8 0.0 0.0018 18.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ETO09046.1 - 0.0009 18.5 2.1 0.022 13.9 0.0 2.4 2 1 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 ETO09046.1 - 0.099 12.9 0.0 0.46 10.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain PRK PF00485.18 ETO09046.1 - 0.14 11.8 2.7 18 5.0 0.0 2.8 2 1 1 3 3 3 0 Phosphoribulokinase / Uridine kinase family SMC_N PF02463.19 ETO09046.1 - 0.2 11.0 0.0 0.2 11.0 0.0 2.6 2 1 1 3 3 3 0 RecF/RecN/SMC N terminal domain Presenilin PF01080.17 ETO09046.1 - 6.3 5.4 7.4 8.1 5.1 7.4 1.2 1 0 0 1 1 1 0 Presenilin SmpA_OmlA PF04355.13 ETO09050.1 - 0.0056 16.4 0.1 0.91 9.4 0.0 2.3 2 0 0 2 2 2 2 SmpA / OmlA family NblA PF04485.12 ETO09050.1 - 0.032 14.6 0.1 0.032 14.6 0.1 3.1 4 0 0 4 4 4 0 Phycobilisome degradation protein nblA DUF4830 PF16112.5 ETO09051.1 - 0.11 13.0 1.3 0.23 12.0 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4830) FAM76 PF16046.5 ETO09051.1 - 0.6 9.4 10.6 0.78 9.0 10.6 1.3 1 0 0 1 1 1 0 FAM76 protein DivIC PF04977.15 ETO09051.1 - 2.5 7.9 17.5 0.53 10.1 4.9 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF948 PF06103.11 ETO09051.1 - 5.5 7.3 11.1 9.5e+02 0.2 10.9 2.2 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 ETO09051.1 - 7.4 7.3 12.4 1.9 9.2 3.3 2.6 1 1 1 2 2 2 0 SlyX DUF898 PF05987.13 ETO09052.1 - 6.3e-05 22.2 3.0 0.00012 21.3 3.0 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF898) zf-LITAF-like PF10601.9 ETO09052.1 - 5.5 7.3 14.9 0.21 11.9 6.2 2.8 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain NinG PF05766.12 ETO09053.1 - 0.014 15.4 0.1 0.016 15.1 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage Lambda NinG protein DUF4446 PF14584.6 ETO09053.1 - 0.014 15.3 0.0 0.019 15.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) NifW PF03206.14 ETO09053.1 - 0.12 12.9 0.4 0.21 12.1 0.4 1.5 1 1 0 1 1 1 0 Nitrogen fixation protein NifW G6B PF15096.6 ETO09053.1 - 0.19 11.5 0.0 0.22 11.3 0.0 1.1 1 0 0 1 1 1 0 G6B family WD40 PF00400.32 ETO09054.1 - 1.2e-39 133.5 28.6 1.5e-06 28.8 0.2 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09054.1 - 2.9e-13 49.9 5.5 0.042 14.1 0.0 6.0 6 1 1 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09054.1 - 4.4e-10 38.8 6.7 0.58 8.7 0.0 5.8 1 1 1 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09054.1 - 7.9e-08 32.0 3.1 0.0021 17.4 0.1 4.3 2 2 1 4 4 4 2 WD40-like domain CLIP_1 PF18322.1 ETO09054.1 - 0.8 9.8 7.1 2.3 8.4 0.8 3.1 3 0 0 3 3 3 0 Serine protease Clip domain PPAF-2 WD40 PF00400.32 ETO09055.1 - 1.3e-43 146.1 32.4 5.2e-07 30.3 0.2 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09055.1 - 9e-12 45.1 0.7 0.36 11.2 0.0 5.8 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09055.1 - 3.5e-08 33.1 1.5 0.0009 18.7 0.3 3.6 2 1 1 3 3 3 3 WD40-like domain zf-TRAF PF02176.18 ETO09055.1 - 3.6e-07 30.8 1.9 2e-06 28.4 1.9 2.4 1 1 0 1 1 1 1 TRAF-type zinc finger Nup160 PF11715.8 ETO09055.1 - 4.3e-07 29.0 3.9 0.69 8.5 0.1 5.0 2 1 2 5 5 5 3 Nucleoporin Nup120/160 TSC22 PF01166.18 ETO09055.1 - 0.031 14.6 0.9 0.17 12.2 0.9 2.3 1 0 0 1 1 1 0 TSC-22/dip/bun family zf-TRAF_2 PF15965.5 ETO09055.1 - 0.044 14.2 1.5 0.24 11.9 1.4 2.3 1 1 0 1 1 1 0 TRAF-like zinc-finger DUF621 PF04789.15 ETO09055.1 - 0.062 12.5 3.4 0.097 11.8 3.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) VASt PF16016.5 ETO09056.1 - 4.8e-23 82.3 0.7 4.8e-23 82.3 0.7 2.4 2 0 0 2 2 1 1 VAD1 Analog of StAR-related lipid transfer domain DUF2722 PF10846.8 ETO09056.1 - 0.00019 20.6 17.8 0.00019 20.6 17.8 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 ETO09056.1 - 0.0012 18.9 26.3 0.002 18.2 26.3 1.4 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SpoIIP PF07454.11 ETO09056.1 - 0.0067 15.9 8.6 0.011 15.2 8.6 1.3 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) DDHD PF02862.17 ETO09056.1 - 0.011 15.9 9.5 0.011 15.9 9.5 1.7 2 0 0 2 2 2 0 DDHD domain RP-C_C PF11800.8 ETO09056.1 - 0.014 15.5 7.1 0.026 14.6 7.1 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region LMBR1 PF04791.16 ETO09056.1 - 0.015 14.3 0.0 0.015 14.3 0.0 2.2 1 1 0 2 2 1 0 LMBR1-like membrane protein Tim54 PF11711.8 ETO09056.1 - 0.028 13.2 8.7 0.054 12.3 8.7 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CCDC106 PF15794.5 ETO09056.1 - 0.028 14.1 17.0 0.24 11.1 0.0 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 NARP1 PF12569.8 ETO09056.1 - 0.031 13.2 8.2 0.05 12.5 8.2 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CobT PF06213.12 ETO09056.1 - 0.032 13.6 15.2 0.046 13.1 15.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Gp45_2 PF17470.2 ETO09056.1 - 0.037 14.0 0.1 13 5.8 0.0 2.5 2 0 0 2 2 2 0 Phage gene product 45.2 RR_TM4-6 PF06459.12 ETO09056.1 - 0.054 13.3 11.1 0.082 12.7 11.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TERB2 PF15101.6 ETO09056.1 - 0.062 13.4 13.2 0.12 12.5 13.2 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Adaptin_binding PF10199.9 ETO09056.1 - 0.065 13.8 10.2 0.15 12.7 10.2 1.6 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 CCDC53 PF10152.9 ETO09056.1 - 0.066 13.6 10.7 0.12 12.8 10.7 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Band_3_cyto PF07565.13 ETO09056.1 - 0.073 12.9 9.6 0.14 11.9 9.6 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain UcrQ PF02939.16 ETO09056.1 - 0.087 12.8 1.5 14 5.7 0.2 2.6 2 0 0 2 2 2 0 UcrQ family FAM76 PF16046.5 ETO09056.1 - 0.092 12.1 13.4 0.17 11.2 13.4 1.4 1 0 0 1 1 1 0 FAM76 protein CPSF100_C PF13299.6 ETO09056.1 - 0.11 12.6 9.0 0.21 11.8 9.0 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 ETO09056.1 - 0.13 11.5 3.8 0.2 10.8 3.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ctr PF04145.15 ETO09056.1 - 0.2 12.3 6.7 0.23 12.1 4.2 2.3 3 0 0 3 3 2 0 Ctr copper transporter family DUF443 PF04276.12 ETO09056.1 - 0.2 11.4 7.8 0.7 9.7 1.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF443) DUF4820 PF16091.5 ETO09056.1 - 0.29 10.5 14.1 0.6 9.4 14.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Serinc PF03348.15 ETO09056.1 - 0.3 10.0 18.3 0.12 11.2 14.0 2.0 2 0 0 2 2 2 0 Serine incorporator (Serinc) Coilin_N PF15862.5 ETO09056.1 - 0.31 10.9 14.2 0.75 9.6 14.2 1.7 1 0 0 1 1 1 0 Coilin N-terminus Rtf2 PF04641.12 ETO09056.1 - 0.34 10.2 14.0 0.59 9.4 14.0 1.4 1 0 0 1 1 1 0 Rtf2 RING-finger F-protein PF00469.20 ETO09056.1 - 0.39 10.3 8.1 0.73 9.4 8.1 1.4 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef PPL5 PF18168.1 ETO09056.1 - 0.45 9.8 8.2 0.9 8.8 8.2 1.4 1 0 0 1 1 1 0 Prim-pol family 5 Connexin PF00029.19 ETO09056.1 - 0.45 10.2 9.9 1 9.1 9.9 1.6 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 ETO09056.1 - 0.49 10.0 6.6 1.1 8.9 6.6 1.5 1 0 0 1 1 1 0 FAM176 family SR-25 PF10500.9 ETO09056.1 - 0.57 9.8 28.7 0.077 12.6 6.7 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4228 PF14009.6 ETO09056.1 - 0.66 10.3 10.1 0.065 13.6 4.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) DUF3408 PF11888.8 ETO09056.1 - 0.86 9.7 13.4 1.8 8.7 13.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) EIIBC-GUT_N PF03612.14 ETO09056.1 - 1.1 8.9 9.5 2.1 8.1 9.5 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF913 PF06025.12 ETO09056.1 - 1.2 8.0 15.6 0.4 9.6 12.8 1.6 2 0 0 2 2 1 0 Domain of Unknown Function (DUF913) Gti1_Pac2 PF09729.9 ETO09056.1 - 1.3 9.0 13.6 3.7 7.6 13.6 1.7 1 0 0 1 1 1 0 Gti1/Pac2 family Suf PF05843.14 ETO09056.1 - 1.7 8.6 18.4 2.8 7.8 18.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CSG2 PF16965.5 ETO09056.1 - 1.9 7.3 16.2 4 6.3 16.2 1.5 1 0 0 1 1 1 0 Ceramide synthase regulator AIF_C PF14721.6 ETO09056.1 - 2.1 8.7 14.1 4.9 7.5 14.1 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Ureide_permease PF07168.11 ETO09056.1 - 2.7 6.6 8.9 4.8 5.8 8.9 1.3 1 0 0 1 1 1 0 Ureide permease MID_MedPIWI PF18296.1 ETO09056.1 - 3 7.6 20.8 2.3 7.9 18.4 1.9 2 0 0 2 2 2 0 MID domain of medPIWI DUF4834 PF16118.5 ETO09056.1 - 3 8.9 24.6 0.43 11.6 15.7 3.2 2 1 1 3 3 2 0 Domain of unknown function (DUF4834) SID-1_RNA_chan PF13965.6 ETO09056.1 - 3.2 6.1 18.3 0.61 8.4 14.4 1.7 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Sec62 PF03839.16 ETO09056.1 - 5 6.6 13.7 0.8 9.2 6.9 2.3 2 0 0 2 2 2 0 Translocation protein Sec62 Peptidase_S49_N PF08496.10 ETO09056.1 - 5.1 7.1 19.1 1.4 9.0 13.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Presenilin PF01080.17 ETO09056.1 - 5.4 5.7 24.0 0.17 10.6 17.0 1.9 2 0 0 2 2 2 0 Presenilin EOS1 PF12326.8 ETO09056.1 - 6.7 6.6 16.5 1.4 8.8 11.1 2.3 2 0 0 2 2 2 0 N-glycosylation protein Roughex PF06020.11 ETO09056.1 - 7 5.6 12.6 12 4.9 12.6 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Folliculin PF11704.8 ETO09056.1 - 8.4 6.2 14.6 26 4.6 14.6 1.9 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Myc_N PF01056.18 ETO09057.1 - 0.078 12.9 9.3 0.13 12.1 9.3 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.12 ETO09057.1 - 0.12 10.5 18.4 0.13 10.4 18.4 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO09057.1 - 0.18 11.1 13.2 0.2 11.0 13.2 1.1 1 0 0 1 1 1 0 BUD22 DUF2151 PF10221.9 ETO09057.1 - 0.18 10.4 4.9 0.2 10.2 4.9 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator SID-1_RNA_chan PF13965.6 ETO09057.1 - 0.31 9.4 2.3 0.41 9.0 2.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAF PF15715.5 ETO09057.1 - 0.42 11.2 13.5 0.86 10.2 13.5 1.6 1 1 0 1 1 1 0 PCNA-associated factor histone like domain CDC45 PF02724.14 ETO09057.1 - 0.52 8.5 10.6 0.51 8.6 10.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 ETO09057.1 - 0.84 10.1 10.5 0.22 12.0 7.4 1.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking SDA1 PF05285.12 ETO09057.1 - 0.88 8.9 19.3 1 8.7 19.3 1.1 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 ETO09057.1 - 0.89 8.8 18.6 1.3 8.3 18.6 1.2 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 ETO09057.1 - 0.95 9.2 14.7 1.4 8.5 14.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PPP4R2 PF09184.11 ETO09057.1 - 1.1 8.8 20.8 0.17 11.5 17.2 1.5 2 0 0 2 2 2 0 PPP4R2 TRAP_alpha PF03896.16 ETO09057.1 - 1.4 8.0 10.9 2.3 7.3 10.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SLC12 PF03522.15 ETO09057.1 - 1.7 7.6 6.0 2.3 7.1 6.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 AIF_C PF14721.6 ETO09057.1 - 1.8 8.9 5.0 9.1 6.6 3.0 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CobT PF06213.12 ETO09057.1 - 2.9 7.2 16.2 4.1 6.7 16.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 ETO09057.1 - 5.7 4.9 23.7 7.3 4.6 23.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Dicty_REP PF05086.12 ETO09057.1 - 7.7 4.3 15.4 11 3.8 15.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Pes-10 PF07149.11 ETO09057.1 - 9.1 5.2 18.7 13 4.7 18.7 1.2 1 0 0 1 1 1 0 Pes-10 PI3K_1B_p101 PF10486.9 ETO09057.1 - 9.3 3.9 7.5 11 3.7 7.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SMI1_KNR4 PF09346.10 ETO09058.1 - 5.3e-06 26.9 0.8 5.3e-06 26.9 0.8 1.5 2 0 0 2 2 2 1 SMI1 / KNR4 family (SUKH-1) Cullin PF00888.22 ETO09060.1 - 6.8e-145 484.1 17.0 8.8e-145 483.7 17.0 1.1 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ETO09060.1 - 6e-27 93.5 3.4 1.4e-26 92.3 1.3 2.8 2 0 0 2 2 2 1 Cullin protein neddylation domain WD40 PF00400.32 ETO09061.1 - 4.8e-26 90.5 22.3 0.00045 21.0 0.1 8.4 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09061.1 - 8.8e-11 42.0 1.4 0.074 13.4 0.1 6.2 2 2 5 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09061.1 - 0.0002 20.8 0.0 0.0012 18.3 0.1 2.3 3 0 0 3 3 3 1 WD40-like domain Pkinase PF00069.25 ETO09062.1 - 0.095 12.0 2.9 0.77 9.1 0.1 2.1 1 1 1 2 2 2 0 Protein kinase domain DUF2373 PF10180.9 ETO09062.1 - 0.13 12.2 5.2 0.066 13.1 1.6 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2373) Curto_V3 PF07436.11 ETO09062.1 - 0.13 12.6 0.2 0.3 11.5 0.2 1.6 1 0 0 1 1 1 0 Curtovirus V3 protein Piwi PF02171.17 ETO09063.1 - 3e-38 131.8 0.0 3.4e-31 108.6 0.0 2.5 2 1 0 2 2 2 2 Piwi domain DUF1730 PF08331.10 ETO09063.1 - 0.073 13.0 0.1 2.1 8.3 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1730) Oberon_cc PF16312.5 ETO09063.1 - 0.095 12.6 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 Coiled-coil region of Oberon Kelch_6 PF13964.6 ETO09064.1 - 3.2e-09 36.7 2.0 3.2e-05 24.1 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO09064.1 - 5.4e-06 26.3 0.1 0.0001 22.2 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO09064.1 - 8.9e-05 22.0 2.8 0.17 11.5 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Endonuclea_NS_2 PF13930.6 ETO09064.1 - 0.032 14.3 0.1 0.032 14.3 0.1 3.6 4 0 0 4 4 4 0 DNA/RNA non-specific endonuclease Kelch_2 PF07646.15 ETO09064.1 - 0.042 13.8 0.6 1.7 8.7 0.1 3.2 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETO09064.1 - 0.052 13.6 2.3 7.5 6.7 0.4 3.2 3 0 0 3 3 3 0 Kelch motif N_Asn_amidohyd PF14736.6 ETO09064.1 - 0.12 11.5 0.0 0.38 9.9 0.0 1.8 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase START PF01852.19 ETO09064.1 - 0.82 9.0 3.2 2.6 7.4 2.2 1.9 2 0 0 2 2 2 0 START domain WD40 PF00400.32 ETO09065.1 - 3.3e-58 192.3 29.9 2.2e-08 34.6 1.1 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09065.1 - 2.3e-13 50.2 8.8 0.047 14.0 0.1 6.0 1 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09065.1 - 4.2e-10 39.5 8.1 3.6e-05 23.2 0.4 3.4 3 0 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO09065.1 - 2.2e-08 33.2 4.5 0.07 11.8 0.1 5.9 3 1 4 7 7 7 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO09065.1 - 1e-07 31.3 1.2 0.79 8.6 0.0 5.4 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Coat_X PF07552.11 ETO09065.1 - 5.4 6.9 6.5 13 5.7 0.4 3.8 4 0 0 4 4 4 0 Spore Coat Protein X and V domain TauE PF01925.19 ETO09066.1 - 0.0004 20.1 4.4 0.29 10.7 0.6 2.4 2 0 0 2 2 2 2 Sulfite exporter TauE/SafE Peptidase_M56 PF05569.11 ETO09066.1 - 0.013 14.8 4.2 0.023 13.9 0.1 2.4 2 0 0 2 2 2 0 BlaR1 peptidase M56 TRAM1 PF08390.11 ETO09066.1 - 0.12 12.0 0.0 0.12 12.0 0.0 2.6 3 0 0 3 3 3 0 TRAM1-like protein CEP19 PF14933.6 ETO09066.1 - 0.18 12.1 0.0 0.34 11.2 0.0 1.4 1 0 0 1 1 1 0 CEP19-like protein DUF2615 PF11027.8 ETO09066.1 - 0.34 11.1 2.7 20 5.4 0.1 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2615) WBP-1 PF11669.8 ETO09066.1 - 0.88 10.2 6.6 1.4 9.6 0.4 3.3 3 0 0 3 3 3 0 WW domain-binding protein 1 Baculo_11_kDa PF06143.11 ETO09066.1 - 4.2 7.0 6.4 6.1 6.5 0.2 3.3 4 0 0 4 4 4 0 Baculovirus 11 kDa family DUF3671 PF12420.8 ETO09066.1 - 5.2 7.2 7.6 4.4 7.4 0.5 2.9 3 0 0 3 3 3 0 Protein of unknown function DsbD_2 PF13386.6 ETO09066.1 - 6 6.7 12.6 0.16 11.9 2.4 2.7 2 2 0 2 2 2 0 Cytochrome C biogenesis protein transmembrane region Peptidase_C14 PF00656.22 ETO09067.1 - 3.5e-05 23.9 2.5 0.00013 22.0 2.5 1.8 1 1 0 1 1 1 1 Caspase domain CX9C PF16860.5 ETO09067.1 - 0.21 11.6 0.2 0.21 11.6 0.2 1.8 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, Kelch_6 PF13964.6 ETO09069.1 - 4e-08 33.3 5.7 0.003 17.8 0.3 3.8 2 1 1 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO09069.1 - 3.8e-07 29.9 5.4 0.00063 19.7 0.5 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO09069.1 - 6.6e-05 22.8 6.6 0.011 15.7 0.4 3.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO09069.1 - 0.00034 20.8 0.7 0.025 14.9 0.1 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO09069.1 - 0.002 17.7 7.9 0.068 12.8 0.3 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO09069.1 - 0.012 15.5 9.7 0.022 14.7 0.4 4.3 5 0 0 5 5 5 0 Kelch motif Type2_restr_D3 PF16902.5 ETO09072.1 - 0.25 11.3 1.9 0.88 9.5 1.9 1.9 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain MCM_OB PF17207.3 ETO09072.1 - 1.2 9.0 11.4 0.22 11.4 5.2 2.9 3 0 0 3 3 3 0 MCM OB domain PDE4_UCR PF18100.1 ETO09072.1 - 4.7 7.9 8.9 5.6 7.6 2.5 3.9 3 0 0 3 3 3 0 Phosphodiesterase 4 upstream conserved regions (UCR) Ferlin_C PF16165.5 ETO09073.1 - 6.7 6.6 10.5 45 3.9 6.4 2.8 2 1 1 3 3 3 0 Ferlin C-terminus WD40 PF00400.32 ETO09075.1 - 2.9e-126 407.7 57.5 8.6e-09 35.9 0.1 17.0 17 0 0 17 17 17 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09075.1 - 2.2e-31 108.0 16.6 0.0027 18.0 0.0 12.8 1 1 13 14 14 14 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09075.1 - 1.8e-18 66.9 8.9 0.00021 20.8 0.0 6.8 4 2 2 7 7 7 3 WD40-like domain NACHT PF05729.12 ETO09075.1 - 4.8e-08 33.1 0.0 1e-07 32.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO09075.1 - 4.5e-06 26.2 6.6 9.3e-06 25.2 6.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_22 PF13401.6 ETO09075.1 - 0.00029 21.1 0.0 0.00091 19.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain Str_synth PF03088.16 ETO09075.1 - 0.00077 19.5 0.7 48 4.2 0.0 6.6 3 2 2 6 6 6 0 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO09075.1 - 0.00086 19.4 1.2 0.0027 17.9 1.2 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO09075.1 - 0.0019 18.7 0.0 0.0092 16.5 0.0 2.3 1 0 0 1 1 1 1 AAA domain Pentapeptide_3 PF13576.6 ETO09075.1 - 0.0019 18.3 2.1 0.0063 16.6 2.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO09075.1 - 0.0066 16.5 18.0 3.9 7.6 0.3 8.8 5 4 3 8 8 7 1 Family of unknown function (DUF5570) RsgA_GTPase PF03193.16 ETO09075.1 - 0.024 14.6 0.3 0.22 11.4 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase PD40 PF07676.12 ETO09075.1 - 0.049 13.6 5.5 56 3.8 0.2 5.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat RelA_SpoT PF04607.17 ETO09075.1 - 0.064 13.6 4.9 0.19 12.0 0.3 3.3 3 0 0 3 3 3 0 Region found in RelA / SpoT proteins Zeta_toxin PF06414.12 ETO09075.1 - 0.065 12.5 0.1 1.1 8.5 0.0 2.5 2 0 0 2 2 2 0 Zeta toxin ATP_bind_2 PF03668.15 ETO09075.1 - 0.1 11.9 0.0 0.2 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop ATPase protein family Chorion_2 PF03964.15 ETO09076.1 - 0.46 11.3 5.7 2 9.3 1.1 2.7 2 1 0 2 2 2 0 Chorion family 2 Abhydrolase_9_N PF15420.6 ETO09077.1 - 0.61 10.1 7.7 1.2 9.1 7.7 1.5 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus RGS PF00615.19 ETO09078.1 - 0.019 15.2 0.6 0.053 13.8 0.0 2.0 2 0 0 2 2 2 0 Regulator of G protein signaling domain PUF PF00806.19 ETO09079.1 - 0.00045 19.7 2.0 0.021 14.5 0.2 3.1 3 0 0 3 3 3 2 Pumilio-family RNA binding repeat ARTD15_N PF18084.1 ETO09080.1 - 0.086 13.1 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 ARTD15 N-terminal domain NPP1 PF05630.11 ETO09081.1 - 0.0048 17.0 0.7 0.0048 17.0 0.7 1.2 1 0 0 1 1 1 1 Necrosis inducing protein (NPP1) Dicty_CAR PF05462.11 ETO09082.1 - 3e-07 29.9 4.0 3.8e-07 29.5 4.0 1.2 1 0 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_1 PF00001.21 ETO09082.1 - 4.4e-07 29.5 0.5 7.9e-07 28.7 0.5 1.4 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Git3 PF11710.8 ETO09082.1 - 0.00054 19.8 8.4 0.0012 18.7 8.4 1.5 1 1 0 1 1 1 1 G protein-coupled glucose receptor regulating Gpa2 Frizzled PF01534.17 ETO09082.1 - 0.092 11.8 11.8 1.3 8.0 0.1 2.1 1 1 1 2 2 2 0 Frizzled/Smoothened family membrane region TPR_2 PF07719.17 ETO09083.1 - 3.6e-09 36.1 7.8 0.00032 20.6 0.2 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09083.1 - 8.5e-09 34.9 8.8 0.0002 21.0 0.4 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09083.1 - 3.8e-06 26.5 6.8 0.015 15.0 0.4 3.7 3 1 1 4 4 4 3 TPR repeat TPR_12 PF13424.6 ETO09083.1 - 1.3e-05 25.4 2.5 1.8e-05 24.9 0.8 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09083.1 - 2e-05 24.4 6.8 0.12 12.6 0.6 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO09083.1 - 2.7e-05 24.2 0.0 6.8e-05 22.9 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO09083.1 - 0.0025 18.5 4.9 3.9 8.6 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO09083.1 - 0.0052 16.0 2.5 0.13 11.4 2.0 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO09083.1 - 0.0098 16.5 1.4 0.35 11.6 0.2 3.1 2 1 2 4 4 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO09083.1 - 0.012 15.9 3.2 0.012 15.9 3.2 1.8 2 0 0 2 2 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ETO09083.1 - 0.016 15.5 2.0 0.41 11.1 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO09083.1 - 0.024 15.1 3.7 0.024 15.1 3.7 4.1 3 1 2 5 5 5 0 Tetratricopeptide repeat TPR_20 PF14561.6 ETO09083.1 - 0.027 14.8 2.9 0.1 12.9 1.1 2.9 1 1 0 2 2 2 0 Tetratricopeptide repeat SEA PF01390.20 ETO09083.1 - 0.048 13.8 0.5 2.5 8.2 0.1 2.3 2 0 0 2 2 2 0 SEA domain TPR_6 PF13174.6 ETO09083.1 - 0.11 13.2 9.9 16 6.4 0.8 4.8 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09083.1 - 0.17 11.9 9.6 1 9.5 0.2 3.5 5 0 0 5 5 3 0 Tetratricopeptide repeat ACP_PD PF04336.12 ETO09083.1 - 0.18 12.2 5.2 0.31 11.5 0.7 2.7 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase MMR_HSR1_C PF08438.10 ETO09083.1 - 0.62 10.7 4.5 8.7 7.0 0.5 2.8 2 1 1 3 3 3 0 GTPase of unknown function C-terminal Prefoldin_2 PF01920.20 ETO09083.1 - 3.1 7.8 12.8 0.036 14.0 1.9 2.9 2 1 1 3 3 3 0 Prefoldin subunit Fis1_TPR_C PF14853.6 ETO09083.1 - 5.3 7.2 8.0 8.1 6.6 1.2 3.4 2 1 1 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Menin PF05053.13 ETO09084.1 - 0.087 11.2 6.7 0.34 9.2 2.1 2.2 2 0 0 2 2 2 0 Menin rRNA_processing PF08524.11 ETO09084.1 - 1 9.4 6.7 12 5.9 4.9 2.1 2 0 0 2 2 2 0 rRNA processing RepA_C PF04796.12 ETO09084.1 - 1.3 9.1 4.9 0.2 11.6 0.6 1.8 2 0 0 2 2 2 0 Plasmid encoded RepA protein CENP-B_dimeris PF09026.10 ETO09084.1 - 1.8 9.0 7.4 0.71 10.3 3.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4558 PF15104.6 ETO09084.1 - 8.2 6.6 8.1 0.28 11.3 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4558) SKA1 PF07160.12 ETO09085.1 - 8e-23 81.5 11.8 4e-17 62.9 3.9 2.0 1 1 1 2 2 2 2 Spindle and kinetochore-associated protein 1 BPL_N PF09825.9 ETO09085.1 - 0.047 12.8 0.9 0.055 12.5 0.9 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal BLOC1_2 PF10046.9 ETO09085.1 - 0.42 10.9 4.6 0.77 10.1 0.2 3.1 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 LexA_DNA_bind PF01726.16 ETO09088.1 - 0.062 13.1 0.3 0.38 10.6 0.2 2.1 2 0 0 2 2 2 0 LexA DNA binding domain Histidinol_dh PF00815.20 ETO09090.1 - 6.9 5.6 6.0 7.8 5.4 4.5 1.7 2 0 0 2 2 2 0 Histidinol dehydrogenase WD40 PF00400.32 ETO09091.1 - 6.6e-41 137.5 25.5 8.5e-07 29.6 2.2 8.1 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09091.1 - 2e-12 47.2 3.6 0.73 10.2 0.0 6.2 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09091.1 - 2.8e-12 46.1 6.7 0.0023 16.6 0.1 5.4 1 1 2 5 5 5 5 Nucleoporin Nup120/160 PADR1 PF08063.12 ETO09091.1 - 0.032 14.0 0.5 3.5 7.5 0.2 2.8 2 0 0 2 2 2 0 PADR1 (NUC008) domain DUF2179 PF10035.9 ETO09092.1 - 0.039 13.7 0.3 0.14 11.9 0.3 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) Serpin PF00079.20 ETO09093.1 - 4.3e-14 52.6 0.4 3.6e-13 49.6 0.4 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) Kelch_4 PF13418.6 ETO09093.1 - 0.12 12.4 0.0 0.25 11.4 0.0 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain LZ3wCH PF18517.1 ETO09093.1 - 0.2 11.8 0.0 0.2 11.8 0.0 2.4 3 0 0 3 3 3 0 Leucine zipper with capping helix domain TauD PF02668.16 ETO09096.1 - 3.5e-37 128.7 0.0 4.5e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family DUF971 PF06155.12 ETO09096.1 - 6.5e-07 29.9 0.5 1.8e-06 28.5 0.1 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF971) DUF2796 PF10986.8 ETO09097.1 - 0.075 13.0 4.8 0.13 12.2 4.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) BSP_II PF05432.11 ETO09097.1 - 0.53 9.9 8.3 0.69 9.6 8.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RNase_J_C PF17770.1 ETO09098.1 - 4 8.5 7.5 1.2 10.2 2.6 2.7 2 1 0 2 2 2 0 Ribonuclease J C-terminal domain ACR_tran PF00873.19 ETO09098.1 - 4.4 4.8 13.0 5.8 4.4 13.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family DUF4407 PF14362.6 ETO09098.1 - 5.9 6.1 14.2 8.6 5.6 14.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) E1-E2_ATPase PF00122.20 ETO09099.1 - 5.6e-28 97.7 0.9 5.2e-27 94.5 0.0 2.7 3 0 0 3 3 3 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETO09099.1 - 1.1e-05 25.3 0.3 3.8e-05 23.5 0.3 2.0 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ETO09099.1 - 0.022 14.8 0.0 0.065 13.3 0.0 1.8 1 0 0 1 1 1 0 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO09099.1 - 0.063 13.5 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase ZnuA PF01297.17 ETO09099.1 - 0.092 12.1 0.0 0.23 10.9 0.0 1.6 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic DUF5523 PF17661.1 ETO09102.1 - 0.0023 17.7 10.5 0.0034 17.1 10.4 1.4 1 1 0 1 1 1 1 Family of unknown function (DUF5523) EF-hand_6 PF13405.6 ETO09102.1 - 0.012 15.5 0.1 0.012 15.5 0.1 2.2 2 1 0 2 2 2 0 EF-hand domain Striatin PF08232.12 ETO09102.1 - 0.18 12.4 8.5 0.25 12.0 8.5 1.2 1 0 0 1 1 1 0 Striatin family Sporozoite_P67 PF05642.11 ETO09102.1 - 1.8 6.6 7.0 1.9 6.4 7.0 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CLASP_N PF12348.8 ETO09103.1 - 3.2e-17 62.9 0.6 6.9e-17 61.8 0.6 1.5 1 0 0 1 1 1 1 CLASP N terminal EF-hand_1 PF00036.32 ETO09103.1 - 9.4e-09 34.2 3.0 0.0068 15.9 0.2 4.1 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO09103.1 - 4.8e-07 29.5 2.1 6.9e-05 22.6 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 ETO09103.1 - 9.5e-07 29.2 7.9 0.00041 20.7 0.1 3.5 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO09103.1 - 2.8e-06 26.8 5.2 0.0093 15.8 0.3 3.9 3 0 0 3 3 3 2 EF-hand domain p25-alpha PF05517.12 ETO09103.1 - 0.0019 18.4 5.0 0.31 11.2 0.1 3.3 3 1 0 3 3 3 2 p25-alpha AtuA PF07287.11 ETO09103.1 - 0.032 13.0 0.1 0.053 12.2 0.1 1.3 1 0 0 1 1 1 0 Acyclic terpene utilisation family protein AtuA zf-DNL PF05180.12 ETO09103.1 - 0.13 12.2 0.0 0.32 11.0 0.0 1.6 1 0 0 1 1 1 0 DNL zinc finger G-alpha PF00503.20 ETO09104.1 - 9.9e-91 304.5 4.9 1.3e-90 304.2 4.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO09104.1 - 1.3e-10 41.1 0.3 1.9e-07 30.7 0.1 3.0 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO09104.1 - 0.00054 19.4 4.0 0.023 14.1 0.1 3.0 2 2 1 3 3 3 2 Gtr1/RagA G protein conserved region Roc PF08477.13 ETO09104.1 - 0.0019 18.4 0.6 0.15 12.2 0.1 3.2 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO09104.1 - 0.0029 17.7 0.0 3.2 7.9 0.0 2.5 2 0 0 2 2 2 2 50S ribosome-binding GTPase DUF815 PF05673.13 ETO09104.1 - 0.0053 15.9 0.2 0.024 13.8 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF815) ATP_bind_1 PF03029.17 ETO09104.1 - 0.0089 15.8 0.8 2.9 7.6 0.1 2.4 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein NB-ARC PF00931.22 ETO09104.1 - 0.023 13.9 0.1 0.043 13.0 0.1 1.4 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 ETO09104.1 - 0.031 14.8 0.1 0.073 13.6 0.1 1.6 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ETO09104.1 - 0.049 13.8 0.1 1.5 9.0 0.0 2.4 2 1 0 2 2 2 0 AAA domain Ras PF00071.22 ETO09104.1 - 0.083 12.5 0.8 16 5.1 0.0 3.6 3 1 0 3 3 3 0 Ras family AAA_24 PF13479.6 ETO09104.1 - 0.094 12.4 0.1 0.18 11.5 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO09104.1 - 0.11 13.1 0.9 0.41 11.2 0.4 2.3 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO09104.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ArfGap PF01412.18 ETO09105.1 - 2.1e-12 47.1 0.1 6.1e-12 45.6 0.0 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf FAT PF02259.23 ETO09106.1 - 0.0042 16.4 0.1 0.0055 16.0 0.1 1.3 1 0 0 1 1 1 1 FAT domain TPR_17 PF13431.6 ETO09106.1 - 0.011 16.0 0.1 0.14 12.6 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09106.1 - 0.026 14.2 1.4 0.049 13.3 0.1 2.1 2 0 0 2 2 2 0 TPR repeat bZIP_1 PF00170.21 ETO09107.1 - 0.012 15.7 7.3 0.012 15.7 7.3 2.3 1 1 1 2 2 2 0 bZIP transcription factor ADIP PF11559.8 ETO09107.1 - 0.019 15.0 20.3 0.024 14.7 20.3 1.1 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 ETO09107.1 - 0.087 12.4 5.4 0.1 12.1 5.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Presenilin PF01080.17 ETO09107.1 - 0.11 11.2 1.1 0.12 11.1 1.1 1.1 1 0 0 1 1 1 0 Presenilin Vma12 PF11712.8 ETO09107.1 - 0.22 11.6 2.5 0.29 11.2 2.5 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase ERM PF00769.19 ETO09107.1 - 0.24 11.2 25.1 0.3 10.9 25.1 1.0 1 0 0 1 1 1 0 Ezrin/radixin/moesin family DUF3450 PF11932.8 ETO09107.1 - 0.26 10.6 15.2 0.32 10.2 15.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HSP70 PF00012.20 ETO09107.1 - 0.27 9.4 9.7 0.3 9.2 9.7 1.0 1 0 0 1 1 1 0 Hsp70 protein Mgr1 PF08602.10 ETO09107.1 - 0.42 9.4 6.6 0.5 9.1 6.6 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit CAF1 PF04857.20 ETO09107.1 - 0.64 9.1 5.5 0.73 8.9 5.5 1.0 1 0 0 1 1 1 0 CAF1 family ribonuclease APG6_N PF17675.1 ETO09107.1 - 0.74 10.3 21.2 1.2 9.7 21.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region Sec62 PF03839.16 ETO09107.1 - 0.83 9.1 7.7 1 8.8 7.7 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Moulting_cycle PF04870.16 ETO09107.1 - 0.86 8.8 16.5 1.1 8.5 16.5 1.0 1 0 0 1 1 1 0 Moulting cycle CLN3 PF02487.17 ETO09107.1 - 0.92 8.5 2.5 1.1 8.2 2.5 1.1 1 0 0 1 1 1 0 CLN3 protein Rootletin PF15035.6 ETO09107.1 - 1.2 9.2 21.8 23 4.9 21.9 2.0 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion LMBR1 PF04791.16 ETO09107.1 - 1.4 7.7 5.1 1.6 7.5 5.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FAM60A PF15396.6 ETO09107.1 - 1.8 8.5 10.2 2.2 8.2 10.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF4407 PF14362.6 ETO09107.1 - 2 7.7 6.7 2.7 7.3 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 ETO09107.1 - 2.1 6.8 15.9 2.6 6.6 15.9 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A Afi1 PF07792.12 ETO09107.1 - 2.7 8.5 9.8 4.8 7.7 9.8 1.5 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nucleoporin_FG2 PF15967.5 ETO09107.1 - 5.2 5.5 7.0 5.8 5.3 7.0 1.1 1 0 0 1 1 1 0 Nucleoporin FG repeated region YabA PF06156.13 ETO09107.1 - 7 7.4 17.2 0.5 11.0 8.3 2.3 1 1 1 2 2 2 0 Initiation control protein YabA K_channel_TID PF07941.11 ETO09108.1 - 8.1 7.0 8.2 36 4.9 2.6 2.7 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain AhpC-TSA PF00578.21 ETO09109.1 - 1.4e-26 92.9 0.1 1.9e-26 92.4 0.1 1.2 1 0 0 1 1 1 1 AhpC/TSA family Redoxin PF08534.10 ETO09109.1 - 9.5e-14 51.3 0.1 1.6e-13 50.6 0.1 1.3 1 1 0 1 1 1 1 Redoxin Thioredoxin_8 PF13905.6 ETO09109.1 - 0.0012 19.1 0.0 0.0029 17.9 0.0 1.6 2 0 0 2 2 2 1 Thioredoxin-like Cys_rich_KTR PF14205.6 ETO09110.1 - 0.036 13.9 0.1 0.087 12.6 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR AAA PF00004.29 ETO09110.1 - 0.058 13.8 0.0 0.15 12.5 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO09110.1 - 0.16 12.2 0.0 0.67 10.2 0.0 2.2 1 1 0 1 1 1 0 AAA domain zf-Nse PF11789.8 ETO09111.1 - 0.23 11.3 1.8 0.48 10.3 1.8 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit YcxB PF14317.6 ETO09111.1 - 0.24 11.1 4.4 0.35 10.6 0.2 2.3 2 0 0 2 2 2 0 YcxB-like protein Ste5_C PF12194.8 ETO09113.1 - 0.0068 16.4 0.1 0.014 15.3 0.1 1.5 1 0 0 1 1 1 1 Protein kinase Fus3-binding Peptidase_Mx1 PF15890.5 ETO09113.1 - 0.021 14.3 0.7 2.8 7.3 0.1 2.2 1 1 1 2 2 2 0 Putative zinc-binding metallo-peptidase DUF4446 PF14584.6 ETO09113.1 - 0.04 13.9 0.7 0.16 12.0 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) GTP_EFTU_D2 PF03144.25 ETO09114.1 - 0.054 13.9 0.1 0.07 13.5 0.1 1.2 1 0 0 1 1 1 0 Elongation factor Tu domain 2 TPR_12 PF13424.6 ETO09116.1 - 7e-46 154.4 17.7 4.3e-16 59.0 1.5 3.5 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO09116.1 - 1.9e-20 72.1 2.7 0.00026 20.8 0.2 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09116.1 - 6.7e-19 66.8 23.1 1.1e-05 25.0 1.1 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09116.1 - 7.1e-19 66.4 8.3 0.0001 22.1 0.1 4.7 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09116.1 - 8.2e-16 56.8 21.0 0.0043 17.1 0.6 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09116.1 - 8.4e-16 56.8 19.9 0.0025 17.8 0.4 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO09116.1 - 5.9e-07 29.8 0.0 3.8 8.6 0.0 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO09116.1 - 4.8e-06 26.9 5.4 2.7 8.8 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat zf-UBP PF02148.19 ETO09116.1 - 5.8e-05 23.3 0.4 0.00022 21.5 0.4 2.0 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein TPR_17 PF13431.6 ETO09116.1 - 0.001 19.3 1.0 8.7 7.0 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 ETO09116.1 - 0.0022 18.0 4.9 5.9 7.0 0.0 4.3 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO09116.1 - 0.026 14.3 10.0 2.8 7.7 0.4 4.4 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) YobH PF13996.6 ETO09116.1 - 0.031 14.3 0.2 0.084 12.9 0.1 1.8 2 0 0 2 2 2 0 YobH-like protein TPR_MalT PF17874.1 ETO09116.1 - 0.049 13.0 0.1 0.31 10.3 0.1 1.9 1 1 1 2 2 2 0 MalT-like TPR region SHNi-TPR PF10516.9 ETO09116.1 - 0.059 12.8 1.3 1.1 8.8 0.0 3.2 3 0 0 3 3 3 0 SHNi-TPR GAD-like PF08887.11 ETO09116.1 - 0.08 12.7 0.1 3.4 7.5 0.0 2.7 3 0 0 3 3 3 0 GAD-like domain SLT PF01464.20 ETO09116.1 - 0.87 9.3 4.1 24 4.6 0.2 3.3 3 0 0 3 3 3 0 Transglycosylase SLT domain TPR_11 PF13414.6 ETO09116.1 - 2.8 7.7 19.3 7.6 6.3 0.2 5.3 5 1 1 6 6 6 0 TPR repeat STPPase_N PF16891.5 ETO09117.1 - 7.6e-05 23.1 0.0 0.00018 21.9 0.0 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain WD40 PF00400.32 ETO09118.1 - 1.1e-20 73.5 16.7 7.5e-07 29.8 0.1 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO09118.1 - 1.2e-07 30.8 1.7 0.0021 16.8 0.4 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09118.1 - 1.3e-05 25.4 0.6 0.065 13.5 0.1 3.2 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09118.1 - 0.00051 19.5 0.9 0.1 11.9 0.1 2.3 1 1 1 2 2 2 2 WD40-like domain WD40 PF00400.32 ETO09119.1 - 0.031 15.2 0.0 0.056 14.3 0.0 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat zf-RING_2 PF13639.6 ETO09120.1 - 0.018 15.4 2.8 0.018 15.4 2.8 2.0 2 1 1 3 3 3 0 Ring finger domain zf-C3HC4 PF00097.25 ETO09120.1 - 0.033 14.1 4.7 1 9.3 0.1 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF3342 PF11822.8 ETO09120.1 - 0.1 12.8 2.0 0.15 12.3 2.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) zf-RING-like PF08746.11 ETO09120.1 - 0.27 11.6 7.9 3.8 7.9 7.9 2.5 1 1 0 1 1 1 0 RING-like domain zf-C3HC4_3 PF13920.6 ETO09120.1 - 0.44 10.4 6.9 2.6 8.0 6.9 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO09120.1 - 5.8 6.8 13.6 0.27 11.1 5.2 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 ETO09121.1 - 2.2e-20 72.6 7.6 4.7e-06 27.2 0.3 4.7 4 3 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09121.1 - 0.0025 18.1 0.1 1.7 9.0 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4979 PF16351.5 ETO09121.1 - 0.026 14.7 2.4 3.6 7.8 0.3 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) Nup160 PF11715.8 ETO09121.1 - 0.036 12.7 0.2 1.9 7.1 0.2 2.3 1 1 0 1 1 1 0 Nucleoporin Nup120/160 Ig_6 PF18452.1 ETO09121.1 - 0.07 12.7 0.1 0.62 9.7 0.0 2.3 2 0 0 2 2 2 0 Immunoglobulin domain fn3 PF00041.21 ETO09122.1 - 0.00047 20.5 0.5 0.036 14.4 0.0 3.0 2 1 0 2 2 2 2 Fibronectin type III domain Ras PF00071.22 ETO09123.1 - 4.1e-26 91.5 0.0 5.3e-26 91.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO09123.1 - 1.3e-19 70.6 0.0 1.9e-19 70.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO09123.1 - 3.5e-09 36.4 0.0 4.8e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO09123.1 - 1.3e-05 24.9 0.0 3.5e-05 23.4 0.0 1.7 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO09123.1 - 0.0045 16.4 0.0 0.0096 15.3 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO09123.1 - 0.015 15.4 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase G-alpha PF00503.20 ETO09123.1 - 0.065 12.4 0.1 0.89 8.6 0.1 2.1 2 0 0 2 2 2 0 G-protein alpha subunit Cid2 PF09774.9 ETO09125.1 - 0.047 14.1 2.1 0.068 13.6 2.1 1.2 1 0 0 1 1 1 0 Caffeine-induced death protein 2 Dicty_REP PF05086.12 ETO09125.1 - 0.71 7.8 6.4 0.6 8.0 6.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Rimk_N PF18030.1 ETO09126.1 - 1.3e-12 48.0 0.0 2.1e-12 47.3 0.0 1.3 1 0 0 1 1 1 1 RimK PreATP-grasp domain TOM20_plant PF06552.12 ETO09126.1 - 0.13 12.0 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Plant specific mitochondrial import receptor subunit TOM20 DUF4383 PF14325.6 ETO09127.1 - 0.029 14.6 6.6 0.071 13.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4383) Phage_holin_3_6 PF07332.11 ETO09127.1 - 0.09 12.8 2.5 1.1 9.3 1.6 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III T_cell_tran_alt PF15128.6 ETO09127.1 - 0.24 11.2 0.7 0.49 10.2 0.1 1.8 1 1 1 2 2 2 0 T-cell leukemia translocation-altered DUF1772 PF08592.11 ETO09127.1 - 0.71 10.2 4.3 2.3 8.5 2.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) MgtE PF01769.16 ETO09127.1 - 3.7 8.0 12.1 6 7.3 6.8 2.4 1 1 1 2 2 2 0 Divalent cation transporter LapA_dom PF06305.11 ETO09127.1 - 6.2 6.7 8.9 16 5.4 0.0 3.4 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain WD40 PF00400.32 ETO09128.1 - 8.3e-23 80.3 11.9 6.7e-07 29.9 0.4 5.9 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09128.1 - 5.7e-08 32.9 0.7 0.014 15.7 0.0 3.8 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09128.1 - 0.00064 18.5 4.8 0.19 10.4 0.5 3.5 2 2 2 4 4 4 3 Nucleoporin Nup120/160 SID-1_RNA_chan PF13965.6 ETO09129.1 - 0.063 11.7 3.8 0.073 11.5 3.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 ETO09129.1 - 0.09 12.0 7.3 0.11 11.7 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 ETO09129.1 - 0.37 9.5 12.8 0.35 9.6 12.8 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2201_N PF13203.6 ETO09129.1 - 0.66 9.5 7.9 0.8 9.2 7.9 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain Presenilin PF01080.17 ETO09129.1 - 1.1 8.0 16.8 1.3 7.7 16.8 1.2 1 0 0 1 1 1 0 Presenilin ArAE_2_N PF10337.9 ETO09129.1 - 1.2 8.1 2.4 16 4.4 0.1 2.3 2 1 0 2 2 2 0 Putative ER transporter, 6TM, N-terminal HCO3_cotransp PF00955.21 ETO09129.1 - 1.2 7.8 3.1 1.3 7.8 3.1 1.3 1 0 0 1 1 1 0 HCO3- transporter family Serinc PF03348.15 ETO09129.1 - 2 7.3 6.8 2.6 6.9 6.8 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.7 ETO09129.1 - 3 5.9 10.3 3.2 5.8 10.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CLN3 PF02487.17 ETO09129.1 - 3.1 6.7 6.7 4.6 6.2 6.7 1.3 1 0 0 1 1 1 0 CLN3 protein O-antigen_lig PF13425.6 ETO09129.1 - 3.4 6.4 7.7 4.4 6.0 7.7 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein WD40 PF00400.32 ETO09130.1 - 1.6e-38 130.0 15.5 9.9e-06 26.2 0.1 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO09130.1 - 2.5e-11 42.9 10.3 0.17 10.5 0.1 5.8 2 2 3 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09130.1 - 3.7e-09 36.8 4.3 0.15 12.4 0.0 6.1 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO09131.1 - 4.7e-45 150.7 24.8 3e-07 31.0 0.4 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09131.1 - 5.4e-15 55.5 5.9 0.012 15.9 0.0 5.8 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09131.1 - 6e-10 38.4 11.5 0.005 15.5 0.3 5.2 2 2 1 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO09131.1 - 0.0091 14.8 11.3 0.015 14.1 1.4 4.0 1 1 2 3 3 3 1 Nup133 N terminal like DUF851 PF05867.11 ETO09131.1 - 0.097 12.1 0.0 1.2 8.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF851) DCX PF03607.17 ETO09131.1 - 0.14 12.3 0.2 2 8.6 0.0 2.6 2 0 0 2 2 2 0 Doublecortin DUF908 PF06012.12 ETO09132.1 - 1.6 8.1 17.1 2.6 7.4 17.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) MscS_porin PF12795.7 ETO09134.1 - 0.00097 18.7 7.4 0.0013 18.3 7.4 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain Atg14 PF10186.9 ETO09134.1 - 0.0045 16.1 3.8 0.0054 15.9 3.8 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 ETO09134.1 - 0.0078 13.8 5.1 0.0095 13.5 5.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) UPF0242 PF06785.11 ETO09134.1 - 0.025 14.7 6.8 0.039 14.1 6.8 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FapA PF03961.13 ETO09134.1 - 0.029 13.0 0.2 0.036 12.7 0.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PUMA PF15826.5 ETO09134.1 - 0.048 13.8 0.0 0.077 13.2 0.0 1.4 1 0 0 1 1 1 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis TPR_MLP1_2 PF07926.12 ETO09134.1 - 0.067 13.3 12.3 0.15 12.2 12.3 1.6 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ETO09134.1 - 0.069 12.0 5.9 0.1 11.4 5.9 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein Taxilin PF09728.9 ETO09134.1 - 0.18 11.0 12.2 0.28 10.3 12.2 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein DUF724 PF05266.14 ETO09134.1 - 0.18 11.6 3.6 0.28 11.0 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Dynactin_p22 PF07426.11 ETO09134.1 - 0.33 10.8 8.2 0.56 10.1 7.3 1.6 1 1 1 2 2 2 0 Dynactin subunit p22 DUF745 PF05335.13 ETO09134.1 - 0.36 10.5 5.5 0.54 10.0 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) SlyX PF04102.12 ETO09134.1 - 1.4 9.5 10.9 2.9 8.6 0.7 2.4 1 1 1 2 2 2 0 SlyX CENP-H PF05837.12 ETO09134.1 - 6.9 7.1 10.0 17 5.9 9.9 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) CDC45 PF02724.14 ETO09135.1 - 1.4 7.1 14.8 1.6 6.9 14.8 1.0 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ETO09135.1 - 8.4 4.7 8.9 9.4 4.5 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ubiquitin PF00240.23 ETO09136.1 - 6.2e-14 51.5 0.1 1.2e-13 50.6 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO09136.1 - 4.8e-05 23.1 0.0 8.7e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETO09136.1 - 0.0023 17.8 0.4 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain zf-C2HC_2 PF13913.6 ETO09136.1 - 0.45 10.5 2.2 2.7 8.0 0.1 2.6 2 0 0 2 2 2 0 zinc-finger of a C2HC-type Nucleoside_tran PF01733.18 ETO09139.1 - 0.11 11.9 3.4 0.096 12.0 0.5 1.8 1 1 1 2 2 2 0 Nucleoside transporter EP400_N PF15790.5 ETO09139.1 - 0.12 11.2 0.1 0.15 10.9 0.1 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal MyTH4 PF00784.17 ETO09140.1 - 5.1e-06 26.9 0.8 1.4e-05 25.5 0.0 2.2 3 0 0 3 3 3 1 MyTH4 domain SapB_2 PF03489.17 ETO09140.1 - 0.11 12.6 0.1 2.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Saposin-like type B, region 2 NapB PF03892.14 ETO09140.1 - 0.41 10.7 4.2 1.4 9.0 0.1 2.3 2 0 0 2 2 2 0 Nitrate reductase cytochrome c-type subunit (NapB) Pox_A32 PF04665.12 ETO09143.1 - 0.51 9.8 5.3 7.2 6.0 0.4 2.4 2 1 0 2 2 2 0 Poxvirus A32 protein VRR_NUC PF08774.11 ETO09144.1 - 9.7e-15 54.6 0.0 1.9e-14 53.7 0.0 1.4 1 0 0 1 1 1 1 VRR-NUC domain PIP5K PF01504.18 ETO09145.1 - 1.7e-58 198.0 9.5 2.6e-58 197.4 9.5 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase ERCC4 PF02732.15 ETO09146.1 - 1.5e-14 54.5 0.2 4.5e-14 52.9 0.0 2.0 2 0 0 2 2 2 1 ERCC4 domain PDE4_UCR PF18100.1 ETO09146.1 - 0.27 11.9 4.5 12 6.5 0.2 2.6 2 0 0 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) MPDZ_u10 PF16667.5 ETO09146.1 - 1.3 9.9 5.3 0.74 10.7 1.8 2.4 2 0 0 2 2 2 0 Unstructured region 10 on multiple PDZ protein SR-25 PF10500.9 ETO09147.1 - 0.0076 15.9 7.7 0.0076 15.9 7.7 2.4 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 ETO09147.1 - 0.025 13.0 6.8 0.039 12.4 6.8 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) MID_MedPIWI PF18296.1 ETO09147.1 - 0.19 11.5 12.8 0.52 10.0 3.8 2.4 2 0 0 2 2 2 0 MID domain of medPIWI LRR_8 PF13855.6 ETO09148.1 - 1.6e-10 40.5 23.5 2.8e-05 23.8 5.3 4.0 3 1 1 4 4 4 4 Leucine rich repeat LRR_4 PF12799.7 ETO09148.1 - 1.2e-05 25.6 25.5 0.12 12.8 6.1 4.4 3 1 2 5 5 5 5 Leucine Rich repeats (2 copies) ANAPC4_WD40 PF12894.7 ETO09149.1 - 7.6e-07 29.3 4.0 4.1 7.8 0.0 5.4 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO09149.1 - 7.8e-05 23.4 10.2 0.074 13.9 0.0 6.0 7 0 0 7 7 7 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO09149.1 - 0.00041 20.4 0.4 1.1 9.4 0.1 4.4 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Miga PF10265.9 ETO09149.1 - 0.0019 17.3 1.3 0.0036 16.3 1.3 1.5 1 0 0 1 1 1 1 Mitoguardin Tricorn_PDZ PF14685.6 ETO09149.1 - 0.04 13.9 0.1 0.28 11.2 0.0 2.2 2 0 0 2 2 2 0 Tricorn protease PDZ domain Styelin PF17562.2 ETO09149.1 - 0.057 13.8 1.4 0.14 12.5 1.4 1.7 1 0 0 1 1 1 0 Styelin EMC3_TMCO1 PF01956.16 ETO09151.1 - 0.039 13.7 0.1 0.039 13.7 0.1 3.4 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like TFIIA PF03153.13 ETO09151.1 - 0.12 12.4 31.9 0.19 11.7 31.9 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Otopetrin PF03189.13 ETO09151.1 - 4.8 5.9 14.0 11 4.7 14.0 1.6 1 1 0 1 1 1 0 Otopetrin Borrelia_P83 PF05262.11 ETO09151.1 - 8.2 4.8 28.9 11 4.3 28.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Sulfotransfer_1 PF00685.27 ETO09152.1 - 0.012 15.1 1.5 0.03 13.8 1.5 1.7 1 1 0 1 1 1 0 Sulfotransferase domain NOA36 PF06524.12 ETO09153.1 - 0.0035 16.7 2.1 0.0035 16.7 2.1 2.7 3 0 0 3 3 3 1 NOA36 protein zf-CCCH_4 PF18044.1 ETO09153.1 - 0.02 14.7 7.4 0.036 13.9 0.1 2.9 2 0 0 2 2 2 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETO09153.1 - 0.036 14.1 1.7 0.036 14.1 1.7 2.6 2 0 0 2 2 2 0 Zinc finger domain CAP_GLY PF01302.25 ETO09155.1 - 4.9e-06 26.5 0.0 8.9e-06 25.6 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain Fez1 PF06818.15 ETO09155.1 - 0.26 11.7 47.0 0.19 12.2 24.5 2.8 1 1 1 2 2 2 0 Fez1 MAD PF05557.13 ETO09155.1 - 0.55 8.5 52.7 0.12 10.7 19.8 3.1 1 1 2 3 3 3 0 Mitotic checkpoint protein EzrA PF06160.12 ETO09155.1 - 0.75 7.9 43.8 6.4 4.8 22.7 2.9 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Taxilin PF09728.9 ETO09155.1 - 1.5 8.0 52.5 0.013 14.7 14.1 3.2 1 1 2 3 3 3 0 Myosin-like coiled-coil protein DUF3322 PF11795.8 ETO09155.1 - 4.4 7.3 14.4 0.11 12.5 2.7 2.7 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria N-term (DUF3322) OST-HTH PF12872.7 ETO09156.1 - 5.2e-05 23.0 0.0 0.0001 22.0 0.0 1.4 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Med26_M PF15694.5 ETO09156.1 - 0.016 15.3 10.3 0.023 14.8 10.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 26 middle domain Bcl-2_BAD PF10514.9 ETO09156.1 - 0.077 13.5 1.2 0.13 12.8 1.2 1.3 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD TFIIA PF03153.13 ETO09156.1 - 0.98 9.3 15.1 0.21 11.6 12.0 1.4 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit EIF4E-T PF10477.9 ETO09156.1 - 2.2 7.0 13.2 3 6.6 13.2 1.2 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4175 PF13779.6 ETO09157.1 - 6.2 4.6 25.5 8.1 4.2 25.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) ELM2 PF01448.24 ETO09157.1 - 9.3 7.1 7.8 16 6.3 4.3 2.8 3 0 0 3 3 3 0 ELM2 domain TPR_2 PF07719.17 ETO09158.1 - 3.4 8.0 5.1 3.2 8.1 0.2 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Presenilin PF01080.17 ETO09158.1 - 7.1 5.3 13.3 13 4.4 13.3 1.4 1 0 0 1 1 1 0 Presenilin Utp14 PF04615.13 ETO09158.1 - 8.2 4.9 11.5 11 4.5 11.5 1.1 1 0 0 1 1 1 0 Utp14 protein PQ-loop PF04193.14 ETO09159.1 - 2e-13 49.9 1.0 4.9e-13 48.6 1.0 1.6 1 0 0 1 1 1 1 PQ loop repeat Pex14_N PF04695.13 ETO09159.1 - 0.15 12.7 1.9 0.15 12.7 0.3 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region IBR PF01485.21 ETO09160.1 - 0.00028 21.1 17.8 0.00038 20.6 5.6 2.8 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain Zn_Tnp_IS91 PF14319.6 ETO09160.1 - 0.68 10.0 13.9 0.32 11.1 3.5 2.6 2 0 0 2 2 2 0 Transposase zinc-binding domain Peptidase_S64 PF08192.11 ETO09161.1 - 0.89 8.0 9.9 1.1 7.6 9.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 zf-met PF12874.7 ETO09162.1 - 0.0015 18.8 1.4 0.022 15.1 0.1 3.0 2 0 0 2 2 2 1 Zinc-finger of C2H2 type PDZ_6 PF17820.1 ETO09164.1 - 0.0037 17.1 0.0 0.007 16.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Csm1_N PF18504.1 ETO09165.1 - 0.0062 16.9 0.5 0.0062 16.9 0.5 2.4 2 0 0 2 2 2 1 Csm1 N-terminal domain Tim54 PF11711.8 ETO09165.1 - 0.014 14.2 1.8 0.015 14.1 0.0 1.8 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 FPN1 PF06963.12 ETO09165.1 - 0.073 11.6 1.8 0.09 11.3 0.2 1.8 2 0 0 2 2 2 0 Ferroportin1 (FPN1) DUF4407 PF14362.6 ETO09165.1 - 0.17 11.2 5.9 2.5 7.4 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF3464 PF11947.8 ETO09165.1 - 0.17 11.6 2.1 0.19 11.5 0.1 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 AflR PF08493.10 ETO09165.1 - 0.77 9.2 13.2 0.11 12.0 9.0 1.7 2 0 0 2 2 2 0 Aflatoxin regulatory protein Zip PF02535.22 ETO09165.1 - 0.99 8.6 4.2 1.6 7.9 0.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter FAM176 PF14851.6 ETO09165.1 - 4.4 7.0 8.9 4.6 6.9 7.1 1.9 2 0 0 2 2 2 0 FAM176 family CSG2 PF16965.5 ETO09165.1 - 4.4 6.1 5.1 0.57 9.1 0.8 1.6 2 0 0 2 2 2 0 Ceramide synthase regulator SKA1 PF07160.12 ETO09165.1 - 8.7 6.1 19.2 0.2 11.5 4.3 2.9 2 1 0 3 3 3 0 Spindle and kinetochore-associated protein 1 SAM_1 PF00536.30 ETO09167.1 - 3.1e-15 56.4 0.2 5.7e-15 55.5 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO09167.1 - 3.5e-14 52.6 0.1 8.2e-14 51.5 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ETO09167.1 - 1.4e-05 25.0 0.3 2.8e-05 24.0 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SpoIIIAH PF12685.7 ETO09167.1 - 0.017 15.0 3.8 0.55 10.0 1.5 2.7 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF2947 PF11163.8 ETO09167.1 - 0.093 12.6 2.5 0.17 11.7 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) SAM_PNT PF02198.16 ETO09167.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain CNDH2_C PF16858.5 ETO09167.1 - 1.4 8.7 16.9 5.5 6.8 9.4 2.6 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nop14 PF04147.12 ETO09167.1 - 3.5 5.7 30.8 0.08 11.2 22.0 2.0 2 0 0 2 2 2 0 Nop14-like family Kelch_6 PF13964.6 ETO09168.1 - 0.00029 21.0 4.4 1.7 9.0 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO09168.1 - 0.0018 17.8 4.4 0.15 11.7 0.1 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO09168.1 - 0.014 15.3 4.1 7.5 6.7 0.3 4.2 4 0 0 4 4 4 0 Kelch motif EMC3_TMCO1 PF01956.16 ETO09168.1 - 0.053 13.2 0.3 0.091 12.5 0.3 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Kelch_5 PF13854.6 ETO09168.1 - 0.16 12.0 8.2 0.12 12.4 0.6 3.7 5 0 0 5 5 5 0 Kelch motif CDC45 PF02724.14 ETO09169.1 - 2.4 6.4 18.8 3.3 5.9 18.8 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF1077 PF06417.12 ETO09170.1 - 0.054 13.5 0.6 0.11 12.5 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1077) G-alpha PF00503.20 ETO09171.1 - 7.5e-23 81.3 0.7 9e-23 81.0 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Spore_III_AB PF09548.10 ETO09172.1 - 0.072 13.2 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) adh_short PF00106.25 ETO09173.1 - 1.7e-51 174.4 0.4 1.9e-51 174.3 0.4 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO09173.1 - 1.5e-35 122.9 0.1 1.7e-35 122.7 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO09173.1 - 1.6e-12 47.7 0.0 2.1e-12 47.3 0.0 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO09173.1 - 0.00038 20.0 0.0 0.00085 18.9 0.0 1.6 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ETO09173.1 - 0.0014 18.6 0.0 0.0023 17.9 0.0 1.4 1 1 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ETO09173.1 - 0.015 14.8 0.0 0.027 14.0 0.0 1.7 1 1 0 1 1 1 0 NmrA-like family RRM_1 PF00076.22 ETO09174.1 - 2e-13 49.9 0.0 4.3e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RIH_assoc PF08454.11 ETO09175.1 - 0.1 12.5 4.3 0.4 10.6 1.0 2.5 2 1 0 2 2 2 0 RyR and IP3R Homology associated HEPN_MAE_28990 PF18737.1 ETO09175.1 - 0.57 10.1 7.5 7.1 6.5 0.1 2.9 1 1 1 3 3 3 0 MAE_28990/MAE_18760-like HEPN PHD PF00628.29 ETO09176.1 - 1.1e-08 34.9 10.7 1.1e-08 34.9 10.7 3.6 4 0 0 4 4 4 1 PHD-finger BSP_II PF05432.11 ETO09176.1 - 0.0041 16.9 46.9 0.0041 16.9 46.9 2.4 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) MetW PF07021.12 ETO09176.1 - 0.038 13.6 0.8 0.072 12.7 0.8 1.4 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW LAP1C PF05609.12 ETO09177.1 - 1.2 8.1 50.9 0.77 8.8 17.1 2.3 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Androgen_recep PF02166.16 ETO09177.1 - 2.2 7.0 21.3 0.0089 14.9 9.7 2.2 2 0 0 2 2 2 0 Androgen receptor Presenilin PF01080.17 ETO09178.1 - 0.21 10.3 6.1 0.23 10.2 6.1 1.1 1 0 0 1 1 1 0 Presenilin DUF612 PF04747.12 ETO09178.1 - 0.43 9.6 19.6 0.51 9.4 19.6 1.0 1 0 0 1 1 1 0 Protein of unknown function, DUF612 DUF4050 PF13259.6 ETO09178.1 - 2.8 8.2 8.0 3.4 7.9 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) FAM60A PF15396.6 ETO09178.1 - 3.4 7.6 9.2 4.4 7.3 9.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A TMEM40 PF15817.5 ETO09179.1 - 0.095 12.5 0.2 0.24 11.2 0.0 1.7 2 0 0 2 2 2 0 Transmembrane protein 40 family RhoGAP PF00620.27 ETO09183.1 - 4e-23 81.9 0.0 6.8e-23 81.2 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain CENP-B_dimeris PF09026.10 ETO09183.1 - 0.038 14.4 0.5 0.066 13.6 0.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain WD40 PF00400.32 ETO09184.1 - 4.3e-28 97.0 4.6 3.4e-06 27.7 0.5 7.1 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09184.1 - 6.4e-16 58.4 2.0 0.00094 19.4 0.0 5.1 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO09184.1 - 8.4e-09 35.6 3.0 4.7e-05 23.4 0.0 3.9 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO09184.1 - 6.9e-06 25.3 0.8 0.83 8.6 0.1 4.3 2 2 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ETO09184.1 - 7.7e-06 25.6 0.0 0.78 9.8 0.0 4.1 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_2 PF13360.6 ETO09184.1 - 2.7e-05 23.9 0.1 0.00012 21.7 0.0 2.0 2 0 0 2 2 2 1 PQQ-like domain Cytochrom_D1 PF02239.16 ETO09184.1 - 4e-05 22.3 1.9 0.0025 16.4 0.2 2.8 1 1 1 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO09184.1 - 6.7e-05 22.4 7.3 0.11 11.8 0.3 3.8 2 1 2 4 4 4 2 WD40-like domain Utp8 PF10395.9 ETO09184.1 - 0.0069 14.9 3.7 0.57 8.6 0.1 2.1 2 0 0 2 2 2 2 Utp8 family PD40 PF07676.12 ETO09184.1 - 0.44 10.6 9.6 55 3.9 0.2 4.7 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat ATG16 PF08614.11 ETO09185.1 - 0.00029 21.1 18.5 0.00038 20.7 18.5 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) DUF3573 PF12097.8 ETO09185.1 - 0.001 18.0 8.9 0.0013 17.7 8.9 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3573) Phi_1 PF04674.12 ETO09185.1 - 0.5 9.6 5.2 0.51 9.6 4.7 1.3 1 1 0 1 1 1 0 Phosphate-induced protein 1 conserved region Zip PF02535.22 ETO09185.1 - 0.81 8.8 6.5 0.97 8.6 6.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter LicD PF04991.13 ETO09185.1 - 1.2 9.2 14.9 1.4 9.0 14.9 1.1 1 0 0 1 1 1 0 LicD family DUF4407 PF14362.6 ETO09185.1 - 1.4 8.2 15.1 1.8 7.8 15.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Presenilin PF01080.17 ETO09185.1 - 7 5.3 12.6 8.6 5.0 12.6 1.1 1 0 0 1 1 1 0 Presenilin Hox9_act PF04617.13 ETO09185.1 - 7.1 7.3 7.2 12 6.6 7.2 1.4 1 0 0 1 1 1 0 Hox9 activation region Exonuc_VII_L PF02601.15 ETO09185.1 - 8.7 5.8 14.5 9.8 5.6 14.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cnd1 PF12717.7 ETO09186.1 - 4.9e-06 26.7 0.2 0.0061 16.6 0.0 2.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO09186.1 - 0.00011 22.6 0.1 0.0032 17.8 0.0 2.8 2 1 1 3 3 3 1 HEAT repeats HEAT PF02985.22 ETO09186.1 - 0.079 13.3 3.5 60 4.3 0.0 4.4 4 0 0 4 4 4 0 HEAT repeat TIMELESS PF04821.14 ETO09187.1 - 9.5e-12 44.8 4.0 2.9e-11 43.2 0.5 2.4 2 1 0 3 3 3 1 Timeless protein DUF4834 PF16118.5 ETO09187.1 - 0.22 12.5 3.9 1.1 10.2 3.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TIMELESS PF04821.14 ETO09188.1 - 0.00011 21.6 0.0 0.00011 21.6 0.0 1.5 2 0 0 2 2 2 1 Timeless protein CENP-B_dimeris PF09026.10 ETO09188.1 - 0.23 11.9 6.2 0.37 11.2 6.2 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain D123 PF07065.14 ETO09188.1 - 0.78 8.8 4.3 1.1 8.4 4.3 1.1 1 0 0 1 1 1 0 D123 DUF4611 PF15387.6 ETO09188.1 - 2.2 8.5 10.2 5.8 7.2 10.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) DUF4892 PF16234.5 ETO09190.1 - 0.09 12.2 0.0 0.16 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4892) CAP_GLY PF01302.25 ETO09191.1 - 0 1077.0 130.9 1.3e-17 63.5 0.9 24.6 24 0 0 24 24 24 24 CAP-Gly domain SH3_2 PF07653.17 ETO09191.1 - 0.022 14.4 2.9 3 7.6 0.1 5.3 4 0 0 4 4 4 0 Variant SH3 domain MitMem_reg PF13012.6 ETO09191.1 - 1.9 8.9 5.6 0.83 10.1 0.8 2.6 2 0 0 2 2 2 0 Maintenance of mitochondrial structure and function PDR_CDR PF06422.12 ETO09192.1 - 0.15 12.0 2.9 3.7 7.5 0.0 2.7 2 0 0 2 2 2 0 CDR ABC transporter SID-1_RNA_chan PF13965.6 ETO09193.1 - 0.0014 17.1 0.3 0.002 16.7 0.3 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DUF4094 PF13334.6 ETO09193.1 - 0.0022 18.4 1.7 0.45 11.0 0.1 2.9 2 2 0 2 2 2 1 Domain of unknown function (DUF4094) PP_M1 PF03012.14 ETO09193.1 - 0.0033 17.0 4.8 0.0053 16.3 4.8 1.3 1 0 0 1 1 1 1 Phosphoprotein HetR_C PF18460.1 ETO09193.1 - 0.05 13.5 0.6 0.18 11.8 0.2 2.0 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain NPR3 PF03666.13 ETO09193.1 - 0.11 11.3 6.3 0.13 11.0 6.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sec62 PF03839.16 ETO09193.1 - 0.14 11.7 6.0 0.097 12.2 2.8 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 HemY_N PF07219.13 ETO09193.1 - 0.21 11.8 0.0 1.2 9.4 0.0 2.0 2 0 0 2 2 2 0 HemY protein N-terminus Zip PF02535.22 ETO09193.1 - 0.21 10.8 10.6 1.5 8.0 10.6 1.9 1 1 0 1 1 1 0 ZIP Zinc transporter OAD_gamma PF04277.13 ETO09193.1 - 0.23 12.1 0.0 0.23 12.1 0.0 2.3 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ndc1_Nup PF09531.10 ETO09193.1 - 0.35 9.5 1.6 3.6 6.2 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup RNA_pol_Rpc4 PF05132.14 ETO09193.1 - 0.99 9.8 4.3 1.5 9.2 4.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop14 PF04147.12 ETO09193.1 - 2.8 6.1 17.7 3.8 5.6 17.7 1.1 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 ETO09193.1 - 3.5 6.5 6.2 4.7 6.1 6.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO09193.1 - 4.5 5.9 9.3 1.7 7.3 6.5 1.6 2 0 0 2 2 2 0 Presenilin CobT PF06213.12 ETO09193.1 - 6.6 6.0 13.7 9.2 5.6 13.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Tropomyosin_1 PF12718.7 ETO09194.1 - 5.4e-06 26.6 9.9 5.4e-06 26.6 9.9 3.1 2 1 0 2 2 2 1 Tropomyosin like Laminin_II PF06009.12 ETO09194.1 - 0.013 15.5 4.3 0.013 15.5 4.3 3.4 3 1 1 4 4 4 0 Laminin Domain II Caps_synth_GfcC PF06251.11 ETO09194.1 - 0.53 9.8 5.5 0.087 12.4 1.2 1.8 2 0 0 2 2 2 0 Capsule biosynthesis GfcC DUF948 PF06103.11 ETO09194.1 - 0.98 9.7 9.2 59 4.0 3.4 4.4 4 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 ETO09194.1 - 2.7 7.8 7.7 3.4 7.4 0.7 2.9 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF3782 PF12644.7 ETO09194.1 - 3.5 7.8 9.0 1.9 8.7 0.5 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF3782) ASL_C PF08328.11 ETO09194.1 - 8.1 6.6 9.9 0.33 11.1 2.4 2.5 2 1 0 2 2 2 0 Adenylosuccinate lyase C-terminal Inovirus_Gp2 PF11726.8 ETO09196.1 - 0.26 11.2 5.4 2.7 7.9 0.0 2.7 3 0 0 3 3 3 0 Inovirus Gp2 FAM60A PF15396.6 ETO09196.1 - 1.8 8.5 15.8 0.3 11.1 6.9 2.2 2 0 0 2 2 2 0 Protein Family FAM60A Ank_4 PF13637.6 ETO09197.1 - 2.2e-08 34.5 0.2 2.6e-07 31.1 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO09197.1 - 1.3e-07 31.3 0.0 3.4e-05 23.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO09197.1 - 2.6e-07 31.1 0.0 4e-07 30.5 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO09197.1 - 7.9e-06 26.1 0.1 4.2e-05 23.8 0.1 2.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO09197.1 - 0.016 15.6 0.0 0.034 14.6 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeat DUF294 PF03445.13 ETO09198.1 - 4.3e-05 23.3 0.0 5.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 WD40 PF00400.32 ETO09199.1 - 1.4e-13 51.1 11.0 3.6e-06 27.6 0.1 4.3 4 1 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO09199.1 - 0.00077 18.2 1.1 0.39 9.3 0.0 2.5 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09199.1 - 0.0016 18.7 0.3 3.5 8.0 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO09199.1 - 0.0027 16.5 1.5 0.006 15.4 1.5 1.5 1 1 0 1 1 1 1 Nup133 N terminal like Kelch_4 PF13418.6 ETO09200.1 - 0.00016 21.6 0.5 0.0074 16.3 0.1 2.9 3 0 0 3 3 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO09200.1 - 0.00017 21.1 0.2 0.0077 15.8 0.1 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO09200.1 - 0.0034 17.3 2.9 0.01 15.8 0.2 3.0 4 0 0 4 4 2 1 Kelch motif Astro_capsid_p PF12226.8 ETO09200.1 - 0.019 14.1 17.4 0.035 13.2 17.4 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RNA_pol_3_Rpc31 PF11705.8 ETO09200.1 - 0.042 14.1 22.8 0.08 13.2 22.8 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Kelch_6 PF13964.6 ETO09200.1 - 0.042 14.1 0.8 0.36 11.2 0.1 2.9 3 0 0 3 3 2 0 Kelch motif CDC45 PF02724.14 ETO09200.1 - 0.058 11.7 19.8 0.085 11.1 19.8 1.2 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 ETO09200.1 - 0.31 10.6 23.1 0.6 9.6 23.1 1.4 1 0 0 1 1 1 0 PPP4R2 DUF4746 PF15928.5 ETO09200.1 - 0.33 10.3 18.7 0.48 9.8 18.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_Rpc4 PF05132.14 ETO09200.1 - 0.43 11.0 5.4 0.66 10.4 5.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2052 PF09747.9 ETO09200.1 - 0.48 10.5 23.4 1.1 9.4 21.9 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) BUD22 PF09073.10 ETO09200.1 - 0.48 9.7 22.1 0.68 9.2 22.1 1.2 1 0 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.12 ETO09200.1 - 1.6 8.4 23.1 2.7 7.6 23.1 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Presenilin PF01080.17 ETO09200.1 - 2.7 6.7 9.1 3.7 6.2 9.1 1.2 1 0 0 1 1 1 0 Presenilin SDA1 PF05285.12 ETO09200.1 - 6.2 6.2 30.6 9.1 5.6 30.6 1.2 1 0 0 1 1 1 0 SDA1 DUF5523 PF17661.1 ETO09200.1 - 7.4 6.2 24.1 12 5.5 24.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Nop14 PF04147.12 ETO09200.1 - 7.7 4.6 32.3 10 4.2 32.3 1.1 1 0 0 1 1 1 0 Nop14-like family Vfa1 PF08432.10 ETO09200.1 - 7.9 6.8 19.9 18 5.6 19.9 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FAM60A PF15396.6 ETO09200.1 - 9.2 6.2 11.1 19 5.2 11.1 1.5 1 0 0 1 1 1 0 Protein Family FAM60A DUF913 PF06025.12 ETO09200.1 - 9.3 5.1 10.7 14 4.6 10.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) PseudoU_synth_2 PF00849.22 ETO09201.1 - 2.4e-13 50.5 0.3 2.4e-13 50.5 0.3 2.3 2 2 0 2 2 2 1 RNA pseudouridylate synthase Ins_allergen_rp PF06757.13 ETO09201.1 - 0.01 15.8 1.0 0.02 14.9 1.0 1.6 1 1 0 1 1 1 0 Insect allergen related repeat, nitrile-specifier detoxification Presenilin PF01080.17 ETO09201.1 - 0.3 9.8 1.4 0.37 9.5 1.4 1.3 1 0 0 1 1 1 0 Presenilin DUF2203 PF09969.9 ETO09201.1 - 1 10.1 6.6 1.3 9.7 1.0 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) FDF PF09532.10 ETO09201.1 - 4 8.4 9.2 2.5 9.1 3.3 2.7 3 0 0 3 3 3 0 FDF domain PARP PF00644.20 ETO09203.1 - 5.3e-27 94.7 0.1 1.5e-24 86.7 0.0 2.9 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 ETO09203.1 - 1.1e-09 38.7 0.4 2.9e-09 37.4 0.4 1.8 1 0 0 1 1 1 1 WWE domain DUF2116 PF09889.9 ETO09204.1 - 0.02 14.9 0.4 0.02 14.9 0.4 1.9 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) DUF3899 PF13038.6 ETO09204.1 - 0.14 12.7 3.2 0.16 12.5 3.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) DUF3671 PF12420.8 ETO09204.1 - 5.1 7.2 22.2 82 3.3 22.2 2.0 1 1 0 1 1 1 0 Protein of unknown function WD40 PF00400.32 ETO09205.1 - 0.00011 22.9 10.3 0.059 14.3 0.8 4.7 5 0 0 5 5 5 2 WD domain, G-beta repeat TFIIF_alpha PF05793.12 ETO09205.1 - 0.76 8.3 32.4 1.4 7.4 32.4 1.4 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LAP1C PF05609.12 ETO09205.1 - 1.6 7.7 13.7 2.3 7.2 13.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ribosomal_60s PF00428.19 ETO09205.1 - 7.4 7.2 15.8 9.1 6.9 5.1 2.6 2 0 0 2 2 2 0 60s Acidic ribosomal protein Peptidase_M20 PF01546.28 ETO09206.1 - 1.1e-24 87.3 0.9 1.7e-24 86.7 0.9 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Mrpl_C PF18502.1 ETO09206.1 - 0.099 12.9 0.8 0.17 12.2 0.7 1.5 1 1 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain Pkinase PF00069.25 ETO09207.1 - 4.7e-14 52.4 0.0 6.4e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Herpes_LMP1 PF05297.11 ETO09207.1 - 2.8 7.0 7.5 3.7 6.6 7.5 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) KH_1 PF00013.29 ETO09209.1 - 1.4e-13 50.4 1.6 2.6e-12 46.4 0.1 2.2 2 0 0 2 2 2 1 KH domain RMI1_C PF16099.5 ETO09209.1 - 0.1 12.4 0.1 0.25 11.2 0.0 1.7 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold FAM199X PF15814.5 ETO09209.1 - 0.58 9.2 7.1 0.83 8.6 7.1 1.2 1 0 0 1 1 1 0 Protein family FAM199X SR-25 PF10500.9 ETO09209.1 - 5.2 6.6 18.6 17 4.9 18.6 1.8 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Zip PF02535.22 ETO09210.1 - 0.15 11.3 0.2 0.18 11.0 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter EMP70 PF02990.16 ETO09211.1 - 2e-150 501.9 25.9 2e-150 501.9 25.9 1.8 1 1 1 2 2 2 1 Endomembrane protein 70 Collar PF07484.12 ETO09211.1 - 0.084 12.9 0.0 0.27 11.3 0.0 1.8 1 0 0 1 1 1 0 Phage Tail Collar Domain OATP PF03137.20 ETO09212.1 - 0.12 10.6 0.7 0.17 10.2 0.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family ALMT PF11744.8 ETO09212.1 - 0.13 11.1 7.2 0.18 10.6 7.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TCP PF03634.13 ETO09212.1 - 0.14 12.7 6.3 0.27 11.8 6.3 1.4 1 0 0 1 1 1 0 TCP family transcription factor SelP_N PF04592.14 ETO09212.1 - 0.55 9.6 15.3 0.88 8.9 15.3 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 ETO09212.1 - 0.82 8.4 4.2 1.3 7.7 4.2 1.3 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 ETO09212.1 - 3.2 6.4 5.0 4.2 6.1 5.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF2796 PF10986.8 ETO09213.1 - 0.076 13.0 1.7 0.24 11.3 0.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) Dyp_perox PF04261.12 ETO09214.1 - 0.00043 19.4 0.0 0.00063 18.8 0.0 1.3 1 0 0 1 1 1 1 Dyp-type peroxidase family TFIIA PF03153.13 ETO09215.1 - 0.027 14.5 26.2 0.031 14.3 26.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ECM1 PF05782.11 ETO09215.1 - 0.2 10.5 19.2 0.22 10.4 19.2 1.1 1 0 0 1 1 1 0 Extracellular matrix protein 1 (ECM1) Neur_chan_memb PF02932.16 ETO09215.1 - 6.1 6.8 7.5 7.4 6.6 7.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Peptidase_C78 PF07910.13 ETO09216.1 - 0.0098 15.4 0.4 4.3 6.7 0.0 2.2 2 0 0 2 2 2 2 Peptidase family C78 IFT57 PF10498.9 ETO09216.1 - 0.048 12.6 15.7 0.076 12.0 15.7 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Speriolin_N PF15058.6 ETO09216.1 - 0.055 13.6 1.8 0.13 12.3 1.5 1.7 1 1 1 2 2 2 0 Speriolin N terminus TolA_bind_tri PF16331.5 ETO09216.1 - 0.08 13.0 13.0 4.9 7.3 8.4 2.8 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF1640 PF07798.11 ETO09216.1 - 0.09 12.8 16.7 0.24 11.4 16.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1640) Tenui_N PF05733.11 ETO09216.1 - 0.13 11.8 3.5 0.063 12.8 0.3 1.9 1 1 1 2 2 2 0 Tenuivirus/Phlebovirus nucleocapsid protein DUF3450 PF11932.8 ETO09216.1 - 0.14 11.5 18.4 0.42 9.9 8.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF3584 PF12128.8 ETO09216.1 - 0.15 9.6 12.7 0.19 9.2 12.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Exonuc_VII_L PF02601.15 ETO09216.1 - 0.17 11.4 6.8 0.22 11.0 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit HIP1_clath_bdg PF16515.5 ETO09216.1 - 0.19 12.3 20.0 0.13 12.9 11.5 2.4 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4407 PF14362.6 ETO09216.1 - 0.19 11.0 6.7 0.32 10.3 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 ETO09216.1 - 0.44 10.6 21.3 2.2 8.3 6.0 2.8 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Syntaxin-6_N PF09177.11 ETO09216.1 - 0.51 10.9 9.4 1.1 9.9 9.4 1.6 1 1 0 1 1 1 0 Syntaxin 6, N-terminal PspA_IM30 PF04012.12 ETO09216.1 - 0.58 9.7 17.9 1.9 8.0 9.0 2.2 1 1 1 2 2 2 0 PspA/IM30 family Sec20 PF03908.13 ETO09216.1 - 0.78 9.7 9.2 0.094 12.6 3.5 2.1 2 0 0 2 2 2 0 Sec20 Spc7 PF08317.11 ETO09216.1 - 0.85 8.4 19.4 2.1 7.2 19.4 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein TSNAXIP1_N PF15739.5 ETO09216.1 - 1.1 9.7 14.1 0.11 12.9 6.3 2.3 1 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus NBP1 PF08537.10 ETO09216.1 - 1.2 8.5 16.0 2 7.7 16.0 1.5 1 1 0 1 1 1 0 Fungal Nap binding protein NBP1 ApoC-I PF04691.12 ETO09216.1 - 1.3 9.0 7.8 4.8 7.2 0.3 2.5 2 1 0 2 2 2 0 Apolipoprotein C-I (ApoC-1) Rootletin PF15035.6 ETO09216.1 - 2.1 8.3 15.2 9.6 6.2 1.0 1.9 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Baculo_PEP_C PF04513.12 ETO09216.1 - 2.6 8.1 10.1 1.8 8.6 0.2 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Prefoldin PF02996.17 ETO09216.1 - 2.7 7.9 17.7 9.8e+02 -0.3 17.4 3.5 1 1 0 1 1 1 0 Prefoldin subunit CHD5 PF04420.14 ETO09216.1 - 3.4 7.5 14.1 0.044 13.6 3.9 2.5 2 1 1 3 3 3 0 CHD5-like protein DivIC PF04977.15 ETO09216.1 - 3.7 7.4 27.6 0.7 9.7 3.5 3.9 3 1 1 4 4 4 0 Septum formation initiator CC2-LZ PF16516.5 ETO09216.1 - 3.8 7.9 23.0 1.2 9.5 9.3 3.4 3 1 0 3 3 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator ZapB PF06005.12 ETO09216.1 - 4.1 7.9 23.5 2 8.9 1.3 3.7 2 1 1 3 3 3 0 Cell division protein ZapB DUF4061 PF13270.6 ETO09216.1 - 4.2 7.8 11.8 0.94 9.8 0.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4061) TMPIT PF07851.13 ETO09216.1 - 6.9 5.8 12.2 0.9 8.7 2.8 2.2 1 1 1 2 2 2 0 TMPIT-like protein UPF0242 PF06785.11 ETO09216.1 - 7 6.7 19.1 19 5.3 19.1 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HALZ PF02183.18 ETO09216.1 - 7.4 6.9 15.2 0.39 11.0 1.7 3.5 4 0 0 4 4 4 0 Homeobox associated leucine zipper FlaC_arch PF05377.11 ETO09216.1 - 8 6.9 15.2 5.4 7.5 2.4 3.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) FapA PF03961.13 ETO09216.1 - 9.1 4.8 13.6 26 3.3 13.7 1.6 1 1 1 2 2 2 0 Flagellar Assembly Protein A Kelch_6 PF13964.6 ETO09218.1 - 3.5e-06 27.1 1.3 1.9e-05 24.7 0.2 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO09218.1 - 5.3e-05 22.7 6.5 8.9e-05 22.0 0.2 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO09218.1 - 0.0014 18.5 5.0 0.0045 16.9 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO09218.1 - 0.0024 18.1 1.8 0.0033 17.7 0.0 2.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO09218.1 - 0.0094 15.9 1.7 0.0094 15.9 1.7 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO09218.1 - 0.12 12.4 0.1 0.47 10.5 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Glyco_hydro_38N PF01074.22 ETO09219.1 - 1e-49 169.5 4.5 2.1e-49 168.4 4.5 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 ETO09219.1 - 1.4e-06 28.3 0.0 4.3e-06 26.8 0.0 1.8 1 0 0 1 1 1 1 Alpha mannosidase middle domain H_lectin PF09458.10 ETO09219.1 - 0.0028 17.8 0.9 0.1 12.8 0.0 3.1 2 0 0 2 2 2 1 H-type lectin domain Inhibitor_I29 PF08246.12 ETO09220.1 - 6.8e-17 61.7 6.5 6.8e-17 61.7 6.5 1.7 2 0 0 2 2 2 1 Cathepsin propeptide inhibitor domain (I29) Cytochrom_C1 PF02167.15 ETO09222.1 - 2.1e-56 191.1 0.0 2.5e-56 190.9 0.0 1.0 1 0 0 1 1 1 1 Cytochrome C1 family Med31 PF05669.12 ETO09223.1 - 3.5e-20 71.8 23.2 5.3e-13 48.8 10.3 3.8 2 1 1 3 3 3 2 SOH1 DUF2109 PF09882.9 ETO09224.1 - 0.054 13.5 0.2 0.11 12.5 0.2 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2109) BacA PF02673.18 ETO09224.1 - 0.064 13.0 0.3 0.084 12.6 0.3 1.1 1 0 0 1 1 1 0 Bacitracin resistance protein BacA Babuvirus_MP PF07234.11 ETO09224.1 - 0.35 11.0 2.1 0.68 10.1 2.1 1.5 1 0 0 1 1 1 0 Movement and RNA silencing protein DUF2162 PF09930.9 ETO09225.1 - 0.14 11.6 0.4 0.21 11.0 0.4 1.2 1 0 0 1 1 1 0 Predicted transporter (DUF2162) DHquinase_II PF01220.19 ETO09226.1 - 0.0075 15.9 0.4 0.0075 15.9 0.4 1.9 2 1 0 2 2 2 1 Dehydroquinase class II BLOC1_2 PF10046.9 ETO09226.1 - 0.014 15.6 1.1 0.014 15.6 1.1 3.8 2 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DEAD PF00270.29 ETO09226.1 - 0.015 15.1 3.7 0.022 14.5 1.3 2.4 1 1 1 2 2 2 0 DEAD/DEAH box helicase DMAP_binding PF06464.11 ETO09226.1 - 0.027 15.3 1.2 0.071 13.9 1.2 1.7 1 0 0 1 1 1 0 DMAP1-binding Domain GAS PF13851.6 ETO09226.1 - 0.16 11.3 18.1 0.12 11.7 15.2 2.2 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding COG5 PF10392.9 ETO09226.1 - 0.32 11.2 9.2 0.06 13.5 3.2 2.7 3 1 1 4 4 4 0 Golgi transport complex subunit 5 ASL_C PF08328.11 ETO09226.1 - 0.59 10.2 5.1 1 9.5 2.7 2.3 1 1 1 2 2 2 0 Adenylosuccinate lyase C-terminal OSCP PF00213.18 ETO09226.1 - 0.79 9.8 10.5 1.1 9.4 4.2 2.9 2 1 1 3 3 3 0 ATP synthase delta (OSCP) subunit CdvA PF18822.1 ETO09226.1 - 0.86 9.4 19.9 0.39 10.5 1.1 3.4 2 1 1 3 3 3 0 CdvA-like coiled-coil domain DUF3583 PF12126.8 ETO09226.1 - 1.5 8.2 9.7 0.39 10.1 3.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3583) Exonuc_VII_L PF02601.15 ETO09226.1 - 1.7 8.1 7.9 3.1 7.3 7.9 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 ETO09226.1 - 2.5 8.6 10.3 1.6 9.3 2.1 3.5 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 ETO09226.1 - 2.8 8.3 6.0 3.3 8.0 0.4 3.1 2 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF148 PF02520.17 ETO09226.1 - 3.1 8.0 17.3 2.6 8.2 5.3 3.0 2 1 1 3 3 3 0 Domain of unknown function DUF148 Phage_Mu_Gam PF07352.12 ETO09226.1 - 7.1 6.5 18.0 0.18 11.7 4.0 3.2 2 1 1 3 3 3 0 Bacteriophage Mu Gam like protein CENP-H PF05837.12 ETO09226.1 - 8.2 6.9 12.1 8.7 6.8 7.8 2.7 2 1 1 3 3 3 0 Centromere protein H (CENP-H) Pkr1 PF08636.10 ETO09227.1 - 4.2e-07 30.0 5.6 6.9e-07 29.3 5.6 1.3 1 0 0 1 1 1 1 ER protein Pkr1 DUF2207 PF09972.9 ETO09227.1 - 0.0025 16.6 0.0 0.0029 16.4 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF4271 PF14093.6 ETO09227.1 - 0.036 14.0 6.0 0.055 13.4 6.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4271) CBP_BcsG PF11658.8 ETO09227.1 - 0.039 12.3 2.5 0.049 12.0 0.0 1.9 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG GRDP-like PF07173.12 ETO09227.1 - 0.13 12.9 0.4 0.2 12.3 0.2 1.5 2 0 0 2 2 2 0 Glycine-rich domain-containing protein-like Sporozoite_P67 PF05642.11 ETO09227.1 - 0.23 9.5 3.9 0.3 9.1 3.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RESP18 PF14948.6 ETO09228.1 - 0.11 12.8 0.1 0.3 11.4 0.0 1.6 1 1 1 2 2 2 0 RESP18 domain Kei1 PF08552.11 ETO09228.1 - 0.2 11.5 0.2 0.2 11.5 0.2 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 PDZ_2 PF13180.6 ETO09229.1 - 6.5e-06 26.4 0.0 2.5e-05 24.5 0.0 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 ETO09229.1 - 0.00018 21.3 0.8 0.00028 20.7 0.0 1.7 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ETO09229.1 - 0.00051 20.3 0.4 0.0015 18.8 0.1 1.9 2 0 0 2 2 2 1 PDZ domain Sporozoite_P67 PF05642.11 ETO09230.1 - 0.032 12.3 4.2 0.042 12.0 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen WD40 PF00400.32 ETO09232.1 - 3e-125 404.5 51.6 4.4e-10 40.0 0.1 15.4 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09232.1 - 4.5e-29 100.6 22.0 0.0048 17.2 0.0 12.1 2 1 11 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09232.1 - 1.9e-26 92.9 4.7 0.26 10.2 0.0 13.1 1 1 14 15 15 15 9 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09232.1 - 1.3e-12 47.6 2.0 0.0012 18.3 0.0 7.4 4 2 3 8 8 8 2 WD40-like domain SGL PF08450.12 ETO09232.1 - 2.6e-11 43.6 3.1 0.063 12.9 0.1 6.0 2 2 3 6 6 6 4 SMP-30/Gluconolactonase/LRE-like region Nup160 PF11715.8 ETO09232.1 - 1.5e-09 37.1 32.6 1.3 7.6 0.1 12.3 2 1 10 13 13 13 6 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO09232.1 - 6.8e-09 35.7 2.5 0.69 10.1 0.0 8.7 7 4 2 9 9 9 2 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO09232.1 - 8.2e-05 21.3 3.4 4.3 5.8 0.0 5.7 4 1 3 7 7 7 2 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO09232.1 - 0.0001 21.9 6.1 0.00031 20.3 6.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO09232.1 - 0.00011 22.2 0.1 0.0003 20.9 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) GATase PF00117.28 ETO09232.1 - 0.0015 18.3 1.1 21 4.8 0.0 5.9 3 2 2 6 6 6 0 Glutamine amidotransferase class-I DUF3509 PF12021.8 ETO09232.1 - 0.005 16.6 0.0 4.5 7.1 0.0 3.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3509) Pentapeptide_3 PF13576.6 ETO09232.1 - 0.0079 16.3 1.0 0.027 14.6 1.0 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO09232.1 - 0.02 14.8 29.4 24 5.0 0.0 11.3 14 0 0 14 14 14 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO09232.1 - 0.021 14.9 26.5 8.7 6.5 0.1 10.4 3 2 8 13 13 13 0 Family of unknown function (DUF5570) LytR_cpsA_psr PF03816.14 ETO09232.1 - 0.97 9.6 3.4 2e+02 2.1 0.0 5.4 5 1 2 7 7 7 0 Cell envelope-related transcriptional attenuator domain CDC45 PF02724.14 ETO09234.1 - 0.0069 14.7 10.6 0.008 14.5 10.6 1.1 1 0 0 1 1 1 1 CDC45-like protein Zip PF02535.22 ETO09234.1 - 0.011 14.9 0.4 0.012 14.9 0.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter EOS1 PF12326.8 ETO09234.1 - 0.021 14.7 0.2 0.032 14.1 0.2 1.2 1 0 0 1 1 1 0 N-glycosylation protein RNA_pol_Rpc4 PF05132.14 ETO09234.1 - 0.022 15.2 7.1 0.032 14.7 7.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 SID-1_RNA_chan PF13965.6 ETO09234.1 - 0.052 12.0 0.2 0.067 11.6 0.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 ETO09234.1 - 0.066 11.1 1.9 0.091 10.7 1.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CBP_BcsG PF11658.8 ETO09234.1 - 0.09 11.2 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DDHD PF02862.17 ETO09234.1 - 0.11 12.6 2.2 0.13 12.5 2.2 1.2 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.6 ETO09234.1 - 0.12 12.6 6.9 0.18 12.0 6.9 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BEX PF04538.12 ETO09234.1 - 0.14 12.7 20.5 0.24 12.0 20.3 1.5 1 1 0 1 1 1 0 Brain expressed X-linked like family DUF4834 PF16118.5 ETO09234.1 - 0.15 13.1 12.8 0.08 13.9 10.1 1.9 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) Pannexin_like PF12534.8 ETO09234.1 - 0.16 11.0 1.4 0.24 10.5 1.4 1.2 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 DUF913 PF06025.12 ETO09234.1 - 0.35 9.8 3.5 1.9 7.4 4.5 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO09234.1 - 0.46 9.2 6.1 0.59 8.8 6.1 1.3 1 0 0 1 1 1 0 Presenilin Eapp_C PF10238.9 ETO09234.1 - 0.52 10.4 5.8 0.69 10.0 5.8 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein U1snRNP70_N PF12220.8 ETO09234.1 - 0.61 10.8 13.3 9.5 6.9 10.4 2.4 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal RR_TM4-6 PF06459.12 ETO09234.1 - 0.65 9.8 13.5 1 9.1 13.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2151 PF10221.9 ETO09234.1 - 0.67 8.5 7.9 0.79 8.2 7.9 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Connexin PF00029.19 ETO09234.1 - 1.1 9.0 11.0 1.9 8.2 11.0 1.3 1 0 0 1 1 1 0 Connexin NPR3 PF03666.13 ETO09234.1 - 1.4 7.6 9.0 1.5 7.5 9.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Coilin_N PF15862.5 ETO09234.1 - 3.1 7.6 15.8 5.6 6.8 15.8 1.4 1 0 0 1 1 1 0 Coilin N-terminus PPL5 PF18168.1 ETO09234.1 - 3.1 7.0 8.0 5.1 6.3 8.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 RP-C_C PF11800.8 ETO09234.1 - 4.6 7.3 8.2 3.6 7.6 5.6 1.8 2 0 0 2 2 2 0 Replication protein C C-terminal region GEN1_C PF18380.1 ETO09234.1 - 5.5 7.9 10.4 1.5 9.7 6.9 1.9 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain DUF2828 PF11443.8 ETO09234.1 - 6.6 4.7 10.9 9.3 4.2 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) RPN2_C PF18004.1 ETO09234.1 - 9 6.2 20.3 18 5.2 20.3 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Aegerolysin PF06355.13 ETO09235.1 - 4.1e-27 94.8 0.8 4.1e-27 94.8 0.8 1.8 2 0 0 2 2 2 1 Aegerolysin IIGP PF05049.13 ETO09235.1 - 5.6e-24 84.9 0.3 7.4e-24 84.5 0.3 1.1 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) MMR_HSR1 PF01926.23 ETO09235.1 - 2e-06 27.9 0.0 4e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO09235.1 - 0.0003 20.7 0.1 0.00097 19.1 0.0 1.8 2 0 0 2 2 2 1 RsgA GTPase Roc PF08477.13 ETO09235.1 - 0.00038 20.6 0.0 0.0012 19.1 0.0 1.9 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETO09235.1 - 0.002 18.6 0.1 0.003 18.1 0.1 1.5 1 1 0 1 1 1 1 ABC transporter Septin PF00735.18 ETO09235.1 - 0.0068 15.7 0.1 0.076 12.3 0.0 2.2 2 1 0 2 2 2 1 Septin AAA_29 PF13555.6 ETO09235.1 - 0.035 13.8 0.0 0.081 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO09235.1 - 0.066 13.7 0.2 0.17 12.4 0.2 1.7 1 1 0 1 1 1 0 AAA domain Dynamin_N PF00350.23 ETO09235.1 - 0.073 13.1 1.4 0.48 10.5 1.4 2.3 1 1 0 1 1 1 0 Dynamin family Ras PF00071.22 ETO09235.1 - 0.12 11.9 0.8 2.4 7.8 0.0 2.5 2 1 0 2 2 2 0 Ras family IstB_IS21 PF01695.17 ETO09235.1 - 0.15 11.7 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_16 PF13191.6 ETO09235.1 - 0.24 11.7 0.0 0.56 10.6 0.0 1.5 2 0 0 2 2 1 0 AAA ATPase domain WD40 PF00400.32 ETO09236.1 - 1.5e-16 60.5 9.5 4.6e-05 24.1 0.0 4.2 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO09236.1 - 0.00067 18.4 2.7 0.21 10.2 0.0 2.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09236.1 - 0.0079 16.5 0.3 1.6 9.1 0.1 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CrgA PF06781.12 ETO09237.1 - 0.0023 18.0 0.8 0.0024 17.9 0.8 1.0 1 0 0 1 1 1 1 Cell division protein CrgA EOS1 PF12326.8 ETO09237.1 - 0.006 16.5 1.3 0.0062 16.5 1.3 1.0 1 0 0 1 1 1 1 N-glycosylation protein Orf78 PF06024.12 ETO09237.1 - 0.024 14.9 0.7 0.027 14.7 0.7 1.1 1 0 0 1 1 1 0 Orf78 (ac78) Renin_r PF07850.14 ETO09237.1 - 0.045 14.4 0.8 0.051 14.2 0.8 1.0 1 0 0 1 1 1 0 Renin receptor-like protein DUF2956 PF11169.8 ETO09237.1 - 0.071 13.3 8.9 0.077 13.2 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) SARAF PF06682.12 ETO09237.1 - 0.11 12.1 1.4 0.11 12.2 1.4 1.0 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Connexin PF00029.19 ETO09237.1 - 0.18 11.5 4.8 0.19 11.4 4.8 1.1 1 0 0 1 1 1 0 Connexin MscS_TM PF12794.7 ETO09237.1 - 0.24 10.2 0.5 0.25 10.2 0.5 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 OATP PF03137.20 ETO09237.1 - 0.3 9.3 6.6 0.31 9.3 6.6 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tau95_N PF17682.1 ETO09237.1 - 0.35 11.1 7.5 0.39 10.9 7.5 1.0 1 0 0 1 1 1 0 Tau95 Triple barrel domain EIIBC-GUT_N PF03612.14 ETO09237.1 - 0.47 10.2 3.9 0.47 10.2 3.9 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus tRNA_lig_CPD PF08302.11 ETO09237.1 - 1 8.7 8.6 1 8.8 8.6 1.0 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain DUF1764 PF08576.10 ETO09237.1 - 1 10.3 13.1 1.2 10.1 13.1 1.1 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Eapp_C PF10238.9 ETO09237.1 - 1.2 9.3 6.2 1.2 9.2 6.2 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Ctf8 PF09696.10 ETO09237.1 - 1.6 9.1 7.4 2 8.8 7.4 1.0 1 0 0 1 1 1 0 Ctf8 Peptidase_S49_N PF08496.10 ETO09237.1 - 3.4 7.7 14.9 3.8 7.5 14.9 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DHR-2 PF06920.13 ETO09238.1 - 6.2e-18 64.7 0.7 2e-16 59.8 0.7 2.0 1 1 0 1 1 1 1 Dock homology region 2 zf-RING_12 PF17976.1 ETO09238.1 - 0.099 12.9 0.5 0.19 12.0 0.5 1.5 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain WD40 PF00400.32 ETO09239.1 - 6.5e-29 99.6 16.5 2.5e-07 31.3 0.3 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09239.1 - 1e-11 44.9 3.4 0.00097 19.4 0.1 4.4 4 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO09239.1 - 1.5e-06 28.8 3.3 1.5e-06 28.8 3.3 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger Nup160 PF11715.8 ETO09239.1 - 3.3e-06 26.0 2.0 0.1 11.2 0.2 3.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09239.1 - 6.5e-05 22.4 7.2 0.063 12.6 0.1 4.3 3 1 2 5 5 5 2 WD40-like domain CCDC144C PF14915.6 ETO09239.1 - 0.0037 16.4 8.5 0.0037 16.4 8.5 2.2 1 1 1 2 2 2 1 CCDC144C protein coiled-coil region UPF0239 PF06783.11 ETO09241.1 - 0.014 15.5 0.1 0.052 13.7 0.0 2.0 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) FAD_binding_4 PF01565.23 ETO09242.1 - 0.022 14.5 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain zf-C2H2_9 PF16293.5 ETO09243.1 - 0.018 14.9 0.1 0.057 13.3 0.1 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) PhoU PF01895.19 ETO09243.1 - 7.9 7.0 9.1 1.9 9.0 1.0 3.2 3 1 1 4 4 4 0 PhoU domain zf-H2C2_5 PF13909.6 ETO09243.1 - 9.8 6.0 7.0 3.8 7.4 3.8 2.1 2 0 0 2 2 2 0 C2H2-type zinc-finger domain M16C_assoc PF08367.11 ETO09244.1 - 0.13 11.3 0.0 0.2 10.8 0.0 1.2 1 0 0 1 1 1 0 Peptidase M16C associated 14-3-3 PF00244.20 ETO09245.1 - 1.3e-22 80.4 2.9 1.7e-22 80.1 2.9 1.1 1 0 0 1 1 1 1 14-3-3 protein DUF5618 PF18498.1 ETO09245.1 - 0.0085 16.3 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5618) Copper-bind PF00127.20 ETO09246.1 - 0.041 14.3 0.1 0.074 13.5 0.1 1.4 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Cpn60_TCP1 PF00118.24 ETO09247.1 - 1.3e-11 43.8 0.0 1.4e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family DUF5073 PF16817.5 ETO09247.1 - 0.024 14.7 0.0 0.037 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5073) HOOK PF05622.12 ETO09248.1 - 3.6e-07 28.8 11.8 3.6e-07 28.8 11.8 2.0 1 1 1 2 2 2 1 HOOK protein KASH_CCD PF14662.6 ETO09248.1 - 8.5e-05 22.5 16.9 0.027 14.3 4.3 2.3 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 ETO09248.1 - 0.00033 20.8 18.7 0.0053 16.8 10.1 2.2 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding GAS PF13851.6 ETO09248.1 - 0.00044 19.7 13.7 0.00044 19.7 13.7 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 ETO09248.1 - 0.00056 20.1 32.1 0.0072 16.5 12.6 2.1 1 1 1 2 2 2 2 Tropomyosin like Spc7 PF08317.11 ETO09248.1 - 0.0015 17.5 21.9 0.04 12.8 9.1 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein bZIP_1 PF00170.21 ETO09248.1 - 0.0022 18.0 22.3 0.019 15.0 3.6 3.1 3 1 0 3 3 2 2 bZIP transcription factor HAP1_N PF04849.13 ETO09248.1 - 0.0036 16.6 14.7 0.01 15.1 14.7 1.7 1 1 0 1 1 1 1 HAP1 N-terminal conserved region UPF0242 PF06785.11 ETO09248.1 - 0.0039 17.3 18.2 0.0057 16.8 18.2 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ETO09248.1 - 0.0043 16.2 8.7 0.0043 16.2 8.7 2.0 1 1 1 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 TMF_TATA_bd PF12325.8 ETO09248.1 - 0.0046 17.2 18.0 0.021 15.0 10.6 2.6 1 1 1 2 2 2 1 TATA element modulatory factor 1 TATA binding DUF2353 PF09789.9 ETO09248.1 - 0.0046 16.4 6.5 0.0046 16.4 6.5 2.0 1 1 1 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Phlebovirus_NSM PF07246.11 ETO09248.1 - 0.0055 16.1 15.7 0.031 13.7 8.5 2.0 1 1 1 2 2 2 1 Phlebovirus nonstructural protein NS-M TPR_MLP1_2 PF07926.12 ETO09248.1 - 0.006 16.7 12.9 0.006 16.7 12.9 2.2 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Sec34 PF04136.15 ETO09248.1 - 0.0078 16.1 8.3 0.052 13.4 0.9 2.4 1 1 1 2 2 2 1 Sec34-like family Shugoshin_N PF07558.11 ETO09248.1 - 0.011 15.6 6.1 1.4 8.9 0.4 2.7 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Filament PF00038.21 ETO09248.1 - 0.013 15.1 20.4 0.065 12.8 3.4 2.2 1 1 1 2 2 2 0 Intermediate filament protein Cnn_1N PF07989.11 ETO09248.1 - 0.018 15.2 17.5 0.19 11.9 0.7 3.2 1 1 1 3 3 3 0 Centrosomin N-terminal motif 1 ATG16 PF08614.11 ETO09248.1 - 0.018 15.3 23.8 0.89 9.7 11.2 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 ETO09248.1 - 0.022 15.2 19.6 0.049 14.1 11.6 3.1 1 1 1 2 2 1 0 Cell division protein ZapB Tropomyosin PF00261.20 ETO09248.1 - 0.023 14.1 19.1 0.26 10.6 14.5 2.8 1 1 1 2 2 2 0 Tropomyosin TSC22 PF01166.18 ETO09248.1 - 0.037 14.3 9.3 0.84 10.0 0.3 3.5 2 2 1 3 3 3 0 TSC-22/dip/bun family BLOC1_2 PF10046.9 ETO09248.1 - 0.038 14.3 11.2 0.12 12.6 5.5 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3450 PF11932.8 ETO09248.1 - 0.044 13.1 15.0 0.13 11.6 6.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Exonuc_VII_L PF02601.15 ETO09248.1 - 0.047 13.3 13.3 0.058 13.0 13.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FPP PF05911.11 ETO09248.1 - 0.047 11.9 16.1 0.059 11.6 16.1 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil SlyX PF04102.12 ETO09248.1 - 0.048 14.3 16.9 0.46 11.1 3.7 3.9 1 1 3 4 4 4 0 SlyX DUF724 PF05266.14 ETO09248.1 - 0.052 13.4 18.9 0.077 12.8 9.8 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) BRE1 PF08647.11 ETO09248.1 - 0.078 13.1 21.5 0.96 9.6 3.1 2.7 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase KLRAQ PF10205.9 ETO09248.1 - 0.082 13.2 20.2 0.19 12.0 7.8 3.0 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein Fez1 PF06818.15 ETO09248.1 - 0.092 13.2 17.2 0.18 12.3 17.2 1.5 1 1 0 1 1 1 0 Fez1 FlaC_arch PF05377.11 ETO09248.1 - 0.097 13.1 16.4 2 8.8 1.2 3.7 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 ETO09248.1 - 0.1 13.1 19.8 0.65 10.5 10.5 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region PEARLI-4 PF05278.12 ETO09248.1 - 0.11 12.1 15.1 0.22 11.1 4.0 2.0 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Cauli_AT PF03233.13 ETO09248.1 - 0.16 11.9 11.7 1.2 9.1 2.5 2.3 1 1 1 2 2 2 0 Aphid transmission protein WD40_alt PF14077.6 ETO09248.1 - 0.17 11.8 1.8 0.17 11.7 0.1 2.0 2 0 0 2 2 1 0 Alternative WD40 repeat motif HemX PF04375.14 ETO09248.1 - 0.18 11.0 16.1 0.091 12.0 4.6 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase YabA PF06156.13 ETO09248.1 - 0.19 12.4 15.2 0.86 10.3 2.7 3.1 1 1 2 3 3 3 0 Initiation control protein YabA DUF2205 PF10224.9 ETO09248.1 - 0.2 11.7 13.8 2.2 8.3 1.0 2.8 1 1 2 3 3 3 0 Short coiled-coil protein DUF773 PF05600.12 ETO09248.1 - 0.2 10.4 15.6 0.58 8.8 2.9 2.2 1 1 1 2 2 2 0 CDK5 regulatory subunit-associated protein 3 Leu_zip PF15294.6 ETO09248.1 - 0.2 11.2 17.0 0.22 11.0 13.2 2.0 1 1 1 2 2 2 0 Leucine zipper DUF4200 PF13863.6 ETO09248.1 - 0.22 11.9 21.5 1.7 9.1 18.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Syntaxin-6_N PF09177.11 ETO09248.1 - 0.27 11.8 12.7 1.7 9.3 7.9 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal HAUS-augmin3 PF14932.6 ETO09248.1 - 0.29 10.7 13.7 0.26 10.8 12.1 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF2203 PF09969.9 ETO09248.1 - 0.3 11.8 10.8 0.35 11.6 2.5 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Prefoldin PF02996.17 ETO09248.1 - 0.35 10.8 12.6 1.1 9.2 1.3 3.1 2 1 1 3 3 3 0 Prefoldin subunit HrpB7 PF09486.10 ETO09248.1 - 0.37 11.2 11.4 0.088 13.2 3.0 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) ABC_tran_CTD PF16326.5 ETO09248.1 - 0.38 11.0 11.1 2.8 8.2 0.2 3.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF5082 PF16888.5 ETO09248.1 - 0.39 11.0 12.9 12 6.2 2.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) FlxA PF14282.6 ETO09248.1 - 0.4 10.7 18.6 0.04 13.9 8.5 3.1 2 2 0 2 2 2 0 FlxA-like protein Uso1_p115_C PF04871.13 ETO09248.1 - 0.41 11.0 22.3 0.044 14.1 10.1 2.3 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF4315 PF14193.6 ETO09248.1 - 0.44 10.6 17.7 1.3 9.1 0.3 3.9 3 2 1 4 4 3 0 Domain of unknown function (DUF4315) Ax_dynein_light PF10211.9 ETO09248.1 - 0.45 10.4 18.1 0.24 11.3 1.8 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain TMF_DNA_bd PF12329.8 ETO09248.1 - 0.5 10.4 24.9 0.36 10.8 1.9 3.0 2 1 1 3 3 2 0 TATA element modulatory factor 1 DNA binding AAA_13 PF13166.6 ETO09248.1 - 0.53 8.9 12.9 2 7.0 12.9 1.8 1 1 0 1 1 1 0 AAA domain Fib_alpha PF08702.10 ETO09248.1 - 0.54 10.4 14.8 0.2 11.8 10.7 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CALCOCO1 PF07888.11 ETO09248.1 - 0.55 9.0 20.6 0.69 8.7 20.6 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like GIT_CC PF16559.5 ETO09248.1 - 0.64 9.9 17.7 0.2 11.6 2.2 3.6 3 1 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor EzrA PF06160.12 ETO09248.1 - 0.69 8.0 15.8 0.63 8.2 6.5 2.0 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA CENP-F_leu_zip PF10473.9 ETO09248.1 - 0.72 9.9 21.5 0.15 12.1 8.7 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 ETO09248.1 - 0.72 10.1 20.3 0.24 11.6 10.1 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Nup54 PF13874.6 ETO09248.1 - 0.74 9.9 13.3 0.83 9.8 8.7 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.12 ETO09248.1 - 0.78 10.2 8.0 4.4 7.8 1.3 3.1 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF1515 PF07439.11 ETO09248.1 - 0.83 9.7 11.4 1.3 9.1 2.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Spc24 PF08286.11 ETO09248.1 - 0.84 9.9 19.2 1.1 9.6 2.2 3.4 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 DUF4472 PF14739.6 ETO09248.1 - 0.88 10.3 14.5 0.94 10.2 5.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) Seryl_tRNA_N PF02403.22 ETO09248.1 - 1.1 9.5 17.6 0.16 12.2 7.4 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain End3 PF12761.7 ETO09248.1 - 1.3 9.2 16.7 2.4 8.3 16.7 1.5 1 1 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF4407 PF14362.6 ETO09248.1 - 1.5 8.1 14.0 5.8 6.2 14.0 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) JIP_LZII PF16471.5 ETO09248.1 - 1.7 8.9 13.6 2.4 8.4 4.8 3.0 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II MPS2 PF17060.5 ETO09248.1 - 1.9 7.7 14.3 6.3 6.0 14.3 1.8 1 1 0 1 1 1 0 Monopolar spindle protein 2 FAM76 PF16046.5 ETO09248.1 - 2.3 7.5 16.5 0.58 9.5 8.3 2.2 1 1 1 2 2 2 0 FAM76 protein DivIVA PF05103.13 ETO09248.1 - 2.4 8.2 12.4 1.1 9.3 1.0 2.8 1 1 2 3 3 3 0 DivIVA protein DivIC PF04977.15 ETO09248.1 - 3.5 7.5 22.3 0.66 9.8 0.9 3.7 2 1 2 4 4 4 0 Septum formation initiator XhlA PF10779.9 ETO09248.1 - 4.3 7.6 20.4 0.78 10.0 1.5 3.3 2 1 1 4 4 3 0 Haemolysin XhlA CENP-H PF05837.12 ETO09248.1 - 4.4 7.7 20.2 3.6 8.0 10.2 2.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF4446 PF14584.6 ETO09248.1 - 4.4 7.3 13.0 0.58 10.1 3.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) BST2 PF16716.5 ETO09248.1 - 4.4 7.9 16.8 3.4 8.3 5.3 2.6 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 Sec2p PF06428.11 ETO09248.1 - 4.6 7.3 17.7 3.1 7.8 2.1 3.4 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p V_ATPase_I PF01496.19 ETO09248.1 - 4.8 5.0 10.5 8.8 4.1 10.5 1.5 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1664 PF07889.12 ETO09248.1 - 4.8 7.2 10.8 6.3 6.9 5.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DHR10 PF18595.1 ETO09248.1 - 5.2 7.1 23.1 1.2 9.3 6.3 3.1 1 1 1 3 3 3 0 Designed helical repeat protein 10 domain Prefoldin_2 PF01920.20 ETO09248.1 - 5.5 7.0 23.8 1 9.4 1.2 3.6 2 1 1 4 4 3 0 Prefoldin subunit CC2-LZ PF16516.5 ETO09248.1 - 5.8 7.3 17.1 1.8 9.0 2.8 3.5 1 1 3 4 4 4 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Mto2_bdg PF12808.7 ETO09248.1 - 7.4 7.0 19.8 0.18 12.1 1.4 4.3 2 1 1 3 3 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region TolA_bind_tri PF16331.5 ETO09248.1 - 7.6 6.7 19.0 0.85 9.7 0.2 3.5 2 1 1 3 3 2 0 TolA binding protein trimerisation Swi5 PF07061.11 ETO09248.1 - 8.2 6.6 15.2 7.2 6.8 0.7 3.5 1 1 1 2 2 2 0 Swi5 DUF16 PF01519.16 ETO09248.1 - 9 6.8 15.4 21 5.7 4.8 2.8 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF3552 PF12072.8 ETO09248.1 - 9.6 5.6 24.1 0.24 10.8 9.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) TPR_MLP1_2 PF07926.12 ETO09249.1 - 0.00049 20.2 16.9 0.00049 20.2 16.9 5.9 2 1 3 5 5 5 2 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 ETO09249.1 - 0.00087 19.3 18.8 0.00087 19.3 18.8 6.5 2 2 2 5 5 5 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PspA_IM30 PF04012.12 ETO09249.1 - 0.0024 17.5 13.3 0.0024 17.5 13.3 5.3 2 2 1 3 3 3 1 PspA/IM30 family DUF919 PF06034.11 ETO09249.1 - 0.019 14.8 1.0 0.019 14.8 1.0 8.7 6 2 1 7 7 7 0 Nucleopolyhedrovirus protein of unknown function (DUF919) Fez1 PF06818.15 ETO09249.1 - 0.04 14.4 109.0 0.92 9.9 28.9 4.7 1 1 3 4 4 4 0 Fez1 AAA_13 PF13166.6 ETO09249.1 - 4.5 5.8 95.3 1.2 7.7 24.5 3.8 2 2 1 3 3 3 0 AAA domain IBR PF01485.21 ETO09251.1 - 1.2e-09 38.2 14.8 1.2e-05 25.5 7.4 2.2 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain SLATT_5 PF18160.1 ETO09251.1 - 0.056 12.8 0.2 0.066 12.5 0.2 1.2 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 PRP21_like_P PF12230.8 ETO09251.1 - 0.061 13.2 0.6 0.095 12.6 0.1 1.4 1 1 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein zf_C2H2_10 PF18414.1 ETO09251.1 - 1.4 8.5 12.0 9 5.9 0.7 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger DZR PF12773.7 ETO09251.1 - 3.3 7.8 15.6 12 6.0 9.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon zf-AN1 PF01428.16 ETO09251.1 - 5.1 7.3 15.5 0.37 11.0 8.9 2.4 2 1 1 3 3 3 0 AN1-like Zinc finger OrfB_Zn_ribbon PF07282.11 ETO09251.1 - 5.7 6.9 8.6 1.6 8.7 2.9 2.3 2 0 0 2 2 2 0 Putative transposase DNA-binding domain RGS PF00615.19 ETO09252.1 - 0.04 14.2 1.1 0.087 13.1 1.1 1.5 1 0 0 1 1 1 0 Regulator of G protein signaling domain SPACA7 PF15307.6 ETO09252.1 - 1.5 9.1 10.4 0.076 13.3 3.4 2.4 1 1 1 2 2 2 0 Sperm acrosome-associated protein 7 HupE_UreJ_2 PF13795.6 ETO09255.1 - 0.14 11.8 0.0 0.17 11.6 0.0 1.1 1 0 0 1 1 1 0 HupE / UreJ protein zf-RING_11 PF17123.5 ETO09256.1 - 0.028 14.2 1.1 0.061 13.1 1.1 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-RING_2 PF13639.6 ETO09256.1 - 4.9 7.6 8.3 1 9.7 2.1 2.3 2 0 0 2 2 2 0 Ring finger domain FUSC PF04632.12 ETO09256.1 - 8.9 4.7 5.4 12 4.3 5.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Gti1_Pac2 PF09729.9 ETO09257.1 - 4.2 7.4 8.9 7.4 6.6 8.9 1.5 1 1 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.22 ETO09257.1 - 4.4 6.4 4.9 4.5 6.4 4.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF1152 PF06626.12 ETO09258.1 - 0.19 10.9 0.0 0.26 10.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1152) zf-RanBP PF00641.18 ETO09260.1 - 1.7e-05 24.0 5.7 3.3e-05 23.1 5.7 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Amino_oxidase PF01593.24 ETO09261.1 - 2.1e-24 86.7 0.1 3e-24 86.1 0.1 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETO09261.1 - 5e-14 52.3 0.3 2.3e-13 50.1 0.2 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETO09261.1 - 2.2e-07 30.4 0.1 4.3e-07 29.5 0.1 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETO09261.1 - 2.9e-06 27.1 0.0 4.2e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETO09261.1 - 7.2e-06 26.5 0.2 2.4e-05 24.8 0.2 1.9 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETO09261.1 - 9.7e-05 21.2 0.2 9.7e-05 21.2 0.2 1.6 2 0 0 2 2 2 1 HI0933-like protein FAD_binding_2 PF00890.24 ETO09261.1 - 0.00011 21.4 0.4 0.00016 20.9 0.4 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ETO09261.1 - 0.00017 21.1 0.0 0.0003 20.3 0.0 1.6 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ETO09261.1 - 0.0003 20.0 0.4 0.0007 18.8 0.4 1.6 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ETO09261.1 - 0.00074 18.9 0.1 0.002 17.5 0.1 1.7 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETO09261.1 - 0.0017 17.7 0.0 0.0027 17.0 0.0 1.3 1 0 0 1 1 1 1 Thi4 family AlaDh_PNT_C PF01262.21 ETO09261.1 - 0.002 17.5 0.1 0.0038 16.6 0.1 1.4 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Pyr_redox_3 PF13738.6 ETO09261.1 - 0.0038 16.5 1.0 0.014 14.7 1.0 2.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase ETRAMP PF09716.10 ETO09261.1 - 0.0061 16.6 0.3 0.0061 16.6 0.3 4.4 4 1 0 4 4 3 1 Malarial early transcribed membrane protein (ETRAMP) Lycopene_cycl PF05834.12 ETO09261.1 - 0.032 13.3 0.2 0.065 12.3 0.2 1.5 1 0 0 1 1 1 0 Lycopene cyclase protein NAD_binding_7 PF13241.6 ETO09261.1 - 0.046 14.2 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 Putative NAD(P)-binding 2-Hacid_dh_C PF02826.19 ETO09261.1 - 0.066 12.6 0.3 0.14 11.5 0.3 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Alk_phosphatase PF00245.20 ETO09261.1 - 0.091 11.7 3.3 0.18 10.7 0.2 2.1 2 0 0 2 2 2 0 Alkaline phosphatase TrkA_N PF02254.18 ETO09261.1 - 0.11 12.8 0.4 0.37 11.0 0.4 1.9 1 0 0 1 1 1 0 TrkA-N domain 3HCDH_N PF02737.18 ETO09261.1 - 0.16 11.8 0.2 0.39 10.6 0.2 1.7 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F-box-like PF12937.7 ETO09262.1 - 0.011 15.6 1.8 0.021 14.7 1.8 1.5 1 0 0 1 1 1 0 F-box-like F-box PF00646.33 ETO09262.1 - 0.087 12.7 0.2 0.21 11.5 0.2 1.7 1 0 0 1 1 1 0 F-box domain Cwf_Cwc_15 PF04889.12 ETO09263.1 - 0.03 14.0 14.3 0.038 13.7 14.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NST1 PF13945.6 ETO09263.1 - 0.085 13.0 20.8 0.12 12.5 20.8 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator SDA1 PF05285.12 ETO09263.1 - 0.1 12.0 9.2 0.12 11.8 9.2 1.1 1 0 0 1 1 1 0 SDA1 Macoilin PF09726.9 ETO09263.1 - 0.22 10.1 6.9 0.22 10.1 6.9 1.0 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 ETO09263.1 - 0.29 9.4 6.8 0.35 9.1 6.8 1.0 1 0 0 1 1 1 0 CDC45-like protein GREB1 PF15782.5 ETO09263.1 - 1.5 5.8 8.1 1.8 5.6 8.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer KH_6 PF15985.5 ETO09264.1 - 6.5e-05 23.2 0.1 0.00014 22.2 0.1 1.6 1 0 0 1 1 1 1 KH domain RdRP PF05183.12 ETO09265.1 - 2.7e-18 66.0 0.0 3.7e-18 65.5 0.0 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase zf-Mss51 PF13824.6 ETO09265.1 - 0.15 12.2 1.4 0.9 9.7 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 RdRP PF05183.12 ETO09266.1 - 1.3e-18 67.0 0.0 2.5e-18 66.1 0.0 1.3 1 1 0 1 1 1 1 RNA dependent RNA polymerase RdRP PF05183.12 ETO09267.1 - 4.6e-25 88.3 0.3 5.6e-25 88.0 0.3 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase HalX PF08663.10 ETO09269.1 - 0.02 15.2 2.6 0.092 13.1 0.1 2.6 2 0 0 2 2 2 0 HalX domain H-kinase_dim PF02895.14 ETO09269.1 - 0.096 13.1 0.1 0.096 13.1 0.1 3.8 3 1 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain DUF2203 PF09969.9 ETO09269.1 - 0.11 13.2 18.1 0.79 10.4 0.4 4.2 4 0 0 4 4 4 0 Uncharacterized conserved protein (DUF2203) AI-2E_transport PF01594.16 ETO09269.1 - 0.54 9.4 7.5 0.079 12.1 1.3 2.3 2 1 1 3 3 3 0 AI-2E family transporter Phage_Gp23 PF10669.9 ETO09270.1 - 0.016 15.5 0.4 0.016 15.5 0.4 2.0 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) DUF2615 PF11027.8 ETO09270.1 - 0.039 14.1 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Orf78 PF06024.12 ETO09270.1 - 0.78 10.1 3.2 1.1 9.6 1.8 1.9 1 1 0 1 1 1 0 Orf78 (ac78) APH PF01636.23 ETO09273.1 - 1e-17 64.9 0.0 2e-17 64.0 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Acyl-CoA_dh_N PF02771.16 ETO09273.1 - 4.7e-08 33.7 0.0 8.1e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain EcKinase PF02958.20 ETO09273.1 - 4e-06 26.4 0.4 8.6e-06 25.3 0.4 1.5 1 0 0 1 1 1 1 Ecdysteroid kinase Acyl-CoA_dh_M PF02770.19 ETO09273.1 - 9.1e-05 22.6 0.0 0.00016 21.8 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ETO09274.1 - 4.9e-36 124.2 1.3 5.9e-36 123.9 1.3 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO09274.1 - 3.3e-13 50.1 2.0 4.2e-13 49.7 2.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO09274.1 - 0.0037 17.4 0.0 0.0065 16.6 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain HpaB_N PF11794.8 ETO09274.1 - 0.071 12.8 0.1 0.18 11.4 0.1 1.6 1 1 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal WD40 PF00400.32 ETO09275.1 - 4e-57 188.9 12.7 9.1e-10 39.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09275.1 - 8.1e-28 96.6 0.5 0.001 19.3 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09275.1 - 4.8e-17 61.9 0.2 0.048 12.6 0.0 6.8 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09275.1 - 4.6e-09 36.0 4.7 0.00091 18.6 0.0 3.8 2 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO09275.1 - 4.8e-07 28.8 4.9 0.1 11.2 0.1 4.9 1 1 5 6 6 6 3 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO09275.1 - 7.8e-07 28.5 1.5 0.016 14.3 0.4 2.5 1 1 1 2 2 2 2 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO09275.1 - 2.5e-06 26.5 1.3 0.36 9.5 0.0 4.0 1 1 2 3 3 3 2 Nup133 N terminal like DUF5570 PF17731.1 ETO09275.1 - 3.8e-06 27.0 0.1 2.9 8.0 0.0 4.2 1 1 2 4 4 4 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO09275.1 - 7.7e-06 25.7 2.4 12 6.0 0.1 6.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO09275.1 - 3.2e-05 22.6 1.0 0.18 10.3 0.0 3.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO09275.1 - 4.6e-05 23.1 0.1 4.1 7.5 0.0 5.6 6 0 0 6 6 6 1 PQQ enzyme repeat Nup88 PF10168.9 ETO09275.1 - 0.0037 15.2 0.3 1.8 6.2 0.1 3.1 3 0 0 3 3 3 2 Nuclear pore component Utp8 PF10395.9 ETO09275.1 - 0.0053 15.3 1.6 0.13 10.8 0.1 2.2 1 1 1 2 2 2 1 Utp8 family DPPIV_N PF00930.21 ETO09275.1 - 0.0078 15.0 0.1 0.78 8.4 0.0 3.2 2 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region ArlS_N PF18719.1 ETO09275.1 - 0.011 16.0 2.9 6.3 7.0 0.3 4.3 1 1 4 5 5 5 0 ArlS sensor domain DUF1652 PF07865.11 ETO09275.1 - 0.017 14.9 0.0 7.8 6.4 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF1652) PALB2_WD40 PF16756.5 ETO09275.1 - 0.021 13.8 1.1 2.3 7.0 0.0 3.5 2 2 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain NifU_N PF01592.16 ETO09275.1 - 0.098 12.8 0.0 2.2 8.4 0.0 2.9 2 1 2 4 4 4 0 NifU-like N terminal domain DUF4999 PF16390.5 ETO09275.1 - 0.36 11.1 1.9 34 4.8 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function TH1 PF04858.13 ETO09276.1 - 2.6e-06 26.4 2.8 2.6e-06 26.4 2.8 1.9 1 1 1 2 2 2 1 TH1 protein Curto_V2 PF07325.11 ETO09277.1 - 0.028 14.3 0.6 0.073 12.9 0.6 1.7 1 0 0 1 1 1 0 Curtovirus V2 protein KKLCAg1 PF15204.6 ETO09279.1 - 0.0023 18.0 0.1 0.0043 17.1 0.1 1.4 1 0 0 1 1 1 1 Kita-kyushu lung cancer antigen 1 DUF4302 PF14135.6 ETO09280.1 - 0.0041 17.1 0.3 0.0074 16.2 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4302) Pneumo_M2 PF07380.11 ETO09280.1 - 0.011 16.0 1.9 5.1 7.5 0.5 2.6 2 0 0 2 2 2 0 Pneumovirus M2 protein Sulfotransfer_2 PF03567.14 ETO09281.1 - 4.8e-05 23.4 0.7 0.00031 20.7 0.0 1.8 1 1 0 2 2 2 1 Sulfotransferase family DSBA PF01323.20 ETO09282.1 - 2.5e-20 73.1 0.0 3.1e-20 72.8 0.0 1.1 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ETO09282.1 - 0.0027 17.9 0.0 0.0049 17.0 0.0 1.5 1 1 0 1 1 1 1 Thioredoxin G3P_antiterm PF04309.12 ETO09282.1 - 0.013 14.9 0.1 0.02 14.3 0.1 1.2 1 0 0 1 1 1 0 Glycerol-3-phosphate responsive antiterminator GshA PF08886.11 ETO09282.1 - 0.029 12.9 0.1 0.039 12.5 0.1 1.1 1 0 0 1 1 1 0 Glutamate-cysteine ligase Lipl32 PF12103.8 ETO09282.1 - 0.078 12.6 0.2 0.13 11.9 0.0 1.5 2 0 0 2 2 2 0 Surface lipoprotein of Spirochaetales order MFS_1 PF07690.16 ETO09283.1 - 5.3e-13 48.6 0.6 9.7e-13 47.7 0.2 1.7 1 1 0 1 1 1 1 Major Facilitator Superfamily UNC-93 PF05978.16 ETO09283.1 - 4.7e-06 26.4 2.4 4.7e-06 26.4 2.4 3.2 3 1 0 3 3 3 2 Ion channel regulatory protein UNC-93 DUF4614 PF15391.6 ETO09283.1 - 0.66 9.9 5.3 1 9.4 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Abhydrolase_9_N PF15420.6 ETO09284.1 - 0.0011 19.1 0.2 0.0015 18.6 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta-hydrolase family N-terminus DUF3283 PF11686.8 ETO09284.1 - 0.0078 16.0 0.6 0.026 14.3 0.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3283) GWT1 PF06423.12 ETO09284.1 - 0.077 13.1 12.4 4.5 7.4 12.4 2.2 1 1 0 1 1 1 0 GWT1 Ycf70 PF17382.2 ETO09284.1 - 0.21 12.0 2.9 2.6 8.5 0.6 2.8 2 1 0 2 2 2 0 Uncharacterized Ycf70-like UCH_1 PF13423.6 ETO09285.1 - 0.0004 20.1 1.9 0.00044 20.0 1.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO09285.1 - 0.035 13.6 0.1 0.043 13.3 0.1 1.3 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase SelR PF01641.18 ETO09285.1 - 0.08 13.0 0.8 0.42 10.7 0.0 2.0 1 1 1 2 2 2 0 SelR domain Hamartin PF04388.12 ETO09287.1 - 3.4 6.2 14.1 4.8 5.7 14.1 1.2 1 0 0 1 1 1 0 Hamartin protein Rtf2 PF04641.12 ETO09287.1 - 5.1 6.4 22.8 2.3 7.5 12.8 2.3 2 1 0 2 2 2 0 Rtf2 RING-finger DnaJ PF00226.31 ETO09290.1 - 2.1e-14 53.4 2.4 6e-14 51.9 2.4 1.8 1 0 0 1 1 1 1 DnaJ domain Bac_globin PF01152.21 ETO09290.1 - 0.00093 19.3 0.2 0.003 17.7 0.0 1.9 2 0 0 2 2 2 1 Bacterial-like globin Ank PF00023.30 ETO09291.1 - 4.6e-18 64.8 7.6 2e-06 28.0 0.9 3.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 ETO09291.1 - 3.7e-16 59.3 5.1 3.2e-06 27.6 0.2 3.9 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO09291.1 - 4.2e-16 59.3 6.4 6.7e-08 33.0 2.4 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO09291.1 - 7.5e-14 50.5 3.8 0.00042 20.5 0.3 3.8 3 1 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ETO09291.1 - 1.7e-13 50.5 3.7 2.7e-09 37.1 0.6 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) WD40 PF00400.32 ETO09292.1 - 6.2e-39 131.3 24.0 1.3e-06 29.0 0.5 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO09292.1 - 3.5e-11 42.4 8.6 0.03 13.0 0.2 5.6 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09292.1 - 6.3e-10 39.2 4.6 0.58 10.5 0.0 6.1 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain DUF4979 PF16351.5 ETO09292.1 - 0.002 18.4 5.5 3 8.0 0.0 4.1 2 1 1 4 4 4 2 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO09293.1 - 4.9e-35 119.0 20.4 1.6e-06 28.8 0.9 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09293.1 - 1.7e-10 41.1 6.6 0.11 12.8 0.0 5.9 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09293.1 - 1.2e-09 37.4 11.5 0.0072 15.0 0.1 5.7 2 2 4 6 6 6 5 Nucleoporin Nup120/160 Guanylate_cyc PF00211.20 ETO09294.1 - 2.3e-06 27.4 0.0 3.1e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF4451 PF14616.6 ETO09295.1 - 0.036 14.3 4.7 0.05 13.8 4.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4451) Chal_sti_synt_C PF02797.15 ETO09295.1 - 0.073 13.1 0.1 0.093 12.7 0.1 1.2 1 0 0 1 1 1 0 Chalcone and stilbene synthases, C-terminal domain Paz_1 PF18349.1 ETO09295.1 - 0.17 11.9 2.9 0.23 11.5 2.6 1.4 1 1 0 1 1 1 0 PAZ domain WD40 PF00400.32 ETO09296.1 - 0.007 17.2 0.2 0.025 15.4 0.3 1.8 2 0 0 2 2 2 1 WD domain, G-beta repeat Hid1 PF12722.7 ETO09297.1 - 0.0014 16.9 1.1 0.0016 16.7 1.1 1.0 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein Glycolytic PF00274.19 ETO09297.1 - 0.012 14.3 0.5 0.15 10.8 0.0 2.0 1 1 1 2 2 2 0 Fructose-bisphosphate aldolase class-I PFK PF00365.20 ETO09298.1 - 2e-34 119.2 0.9 2.6e-34 118.8 0.9 1.1 1 0 0 1 1 1 1 Phosphofructokinase TMEM214 PF10151.9 ETO09298.1 - 0.016 13.7 1.8 0.024 13.1 1.8 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator DUF5076 PF16826.5 ETO09298.1 - 0.098 12.6 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5076) RelA_SpoT PF04607.17 ETO09302.1 - 0.0055 17.0 0.3 0.0055 17.0 0.3 2.6 3 0 0 3 3 3 1 Region found in RelA / SpoT proteins WD40 PF00400.32 ETO09303.1 - 2.8e-111 360.2 45.5 9.8e-09 35.7 0.2 15.4 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09303.1 - 4.1e-26 91.1 14.9 0.04 14.2 0.1 13.5 1 1 13 14 14 14 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09303.1 - 1.1e-17 64.0 7.7 0.39 9.6 0.1 12.5 1 1 11 14 14 14 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09303.1 - 4e-10 39.5 8.5 0.0018 17.7 0.1 5.9 3 2 1 5 5 5 3 WD40-like domain PD40 PF07676.12 ETO09303.1 - 2.4e-08 33.7 32.7 0.88 9.6 0.1 12.0 12 0 0 12 12 12 2 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO09303.1 - 3.5e-08 32.9 2.3 9.5e-08 31.5 2.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO09303.1 - 6.3e-07 29.4 0.1 2.5 8.3 0.0 8.0 8 1 1 9 9 9 1 Strictosidine synthase POLO_box PF00659.18 ETO09303.1 - 2e-06 27.9 5.1 4.5 7.5 0.0 9.0 8 2 3 11 11 11 1 POLO box duplicated region Cytochrom_D1 PF02239.16 ETO09303.1 - 2.3e-06 26.4 3.1 2.9 6.3 0.0 5.3 2 1 4 7 7 7 3 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETO09303.1 - 4.7e-05 23.5 0.1 0.00013 22.0 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF1258 PF06869.12 ETO09303.1 - 0.00017 21.2 0.0 4.8 6.6 0.0 4.1 3 1 2 5 5 5 1 Protein of unknown function (DUF1258) Gmad1 PF10647.9 ETO09303.1 - 0.00028 20.7 0.0 0.059 13.1 0.0 3.8 3 1 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF3475 PF11961.8 ETO09303.1 - 0.00084 19.4 1.1 4.5 7.4 0.0 5.3 6 0 0 6 6 5 1 Domain of unknown function (DUF3475) Pentapeptide_3 PF13576.6 ETO09303.1 - 0.012 15.8 0.0 0.037 14.2 0.0 1.9 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF3509 PF12021.8 ETO09303.1 - 0.017 14.8 0.0 10 5.9 0.0 4.2 3 2 2 5 5 5 0 Protein of unknown function (DUF3509) FAINT PF04385.15 ETO09303.1 - 0.085 12.9 1.0 0.29 11.2 1.0 2.0 1 0 0 1 1 1 0 Domain of unknown function, DUF529 DUF5570 PF17731.1 ETO09303.1 - 0.54 10.4 12.9 49 4.0 0.1 6.6 5 2 1 8 8 7 0 Family of unknown function (DUF5570) LRR_8 PF13855.6 ETO09304.1 - 0.00025 20.7 49.0 0.00062 19.5 2.3 8.0 4 1 2 7 7 7 6 Leucine rich repeat LRR_4 PF12799.7 ETO09304.1 - 7 7.2 65.8 0.039 14.4 1.4 9.6 6 1 6 12 12 12 0 Leucine Rich repeats (2 copies) Pkinase PF00069.25 ETO09305.1 - 4.7e-25 88.5 0.1 5.3e-18 65.3 0.0 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09305.1 - 3.1e-14 52.9 0.1 2.8e-11 43.2 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO09305.1 - 0.0099 15.2 0.1 0.026 13.9 0.0 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family TMEM40 PF15817.5 ETO09305.1 - 0.035 13.9 0.2 0.035 13.9 0.2 2.6 3 0 0 3 3 3 0 Transmembrane protein 40 family DUF2663 PF10864.8 ETO09305.1 - 0.19 12.1 9.3 0.088 13.2 1.6 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) LRR19-TM PF15176.6 ETO09306.1 - 2.2 8.3 5.4 0.79 9.8 0.2 2.9 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain Arm PF00514.23 ETO09307.1 - 1e-11 44.4 0.0 0.00018 21.4 0.0 4.0 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETO09307.1 - 0.0044 17.4 0.0 5.4 7.5 0.0 2.5 1 1 0 2 2 2 2 HEAT repeats HEAT_EZ PF13513.6 ETO09307.1 - 0.022 15.3 0.0 6.3 7.4 0.0 2.7 2 0 0 2 2 2 0 HEAT-like repeat HEAT PF02985.22 ETO09307.1 - 0.049 13.9 0.0 4.3 7.9 0.0 3.0 3 0 0 3 3 3 0 HEAT repeat Adaptin_N PF01602.20 ETO09307.1 - 0.12 10.9 0.0 0.8 8.2 0.0 1.8 1 1 1 2 2 2 0 Adaptin N terminal region ATP-gua_PtransN PF02807.15 ETO09307.1 - 0.17 12.3 0.5 14 6.1 0.0 2.8 3 0 0 3 3 3 0 ATP:guanido phosphotransferase, N-terminal domain FYVE PF01363.21 ETO09308.1 - 2.9e-07 30.5 9.2 2.9e-07 30.5 9.2 4.9 2 2 2 4 4 4 1 FYVE zinc finger IBR PF01485.21 ETO09308.1 - 0.0049 17.1 9.5 0.0049 17.1 9.5 6.3 2 2 3 5 5 5 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ETO09308.1 - 0.033 14.0 2.6 0.033 14.0 2.6 6.7 4 3 2 6 6 6 0 Zinc finger, C3HC4 type (RING finger) SR-25 PF10500.9 ETO09308.1 - 4.6 6.8 8.7 9 5.8 8.7 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ELO PF01151.18 ETO09309.1 - 3.6e-20 72.6 0.9 4.2e-20 72.3 0.9 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family AgrB PF04647.15 ETO09309.1 - 0.042 13.2 1.2 0.17 11.2 1.1 1.9 1 1 0 1 1 1 0 Accessory gene regulator B CPSase_C PF18302.1 ETO09310.1 - 0.32 11.5 2.6 1.1 9.9 2.6 1.9 1 0 0 1 1 1 0 Carbamoyl phosphate synthetase C-terminal domain IBB PF01749.20 ETO09311.1 - 2.7e-06 27.7 1.4 9.9e-06 25.9 1.4 1.9 1 1 0 1 1 1 1 Importin beta binding domain DUF3552 PF12072.8 ETO09311.1 - 0.36 10.2 5.4 0.6 9.5 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) O-antigen_lig PF13425.6 ETO09312.1 - 0.03 13.1 4.3 0.012 14.4 1.3 1.7 1 1 1 2 2 2 0 O-antigen ligase like membrane protein DUF4457 PF14652.6 ETO09312.1 - 0.048 12.9 0.3 0.093 12.0 0.1 1.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4457) CDC45 PF02724.14 ETO09313.1 - 0.27 9.5 21.6 0.39 8.9 21.6 1.2 1 0 0 1 1 1 0 CDC45-like protein ECH_1 PF00378.20 ETO09314.1 - 2.5e-33 115.4 0.1 1.9e-15 56.9 0.1 3.1 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO09314.1 - 5.2e-12 45.9 0.0 3.6e-09 36.6 0.0 2.3 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase SSXT PF05030.12 ETO09315.1 - 0.013 15.1 1.7 0.016 14.8 0.2 1.9 2 0 0 2 2 2 0 SSXT protein (N-terminal region) DZR PF12773.7 ETO09315.1 - 0.055 13.5 0.4 0.095 12.7 0.4 1.3 1 0 0 1 1 1 0 Double zinc ribbon Zn_ribbon_17 PF17120.5 ETO09315.1 - 0.066 12.8 0.5 0.13 11.9 0.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type PQQ_3 PF13570.6 ETO09316.1 - 0.13 12.8 0.6 1.7 9.2 0.0 2.4 2 0 0 2 2 2 0 PQQ-like domain TPR_1 PF00515.28 ETO09318.1 - 1.6e-07 30.8 0.6 0.0024 17.6 0.3 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09318.1 - 7e-07 28.9 0.9 0.00081 19.3 0.4 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09318.1 - 8.9e-06 25.3 0.0 0.0041 16.8 0.0 2.9 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO09318.1 - 0.00039 20.6 0.3 0.091 13.2 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO09318.1 - 0.049 14.3 0.0 0.12 13.1 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO09318.1 - 0.07 13.4 1.3 0.93 9.8 0.2 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO09318.1 - 0.084 13.4 0.0 0.21 12.1 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat S_locus_glycop PF00954.20 ETO09318.1 - 0.12 12.9 0.1 0.45 11.0 0.1 2.0 1 0 0 1 1 1 0 S-locus glycoprotein domain TPR_6 PF13174.6 ETO09318.1 - 0.16 12.7 0.0 3 8.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Metallophos PF00149.28 ETO09319.1 - 4.3e-12 47.0 3.6 8.3e-12 46.0 3.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ETO09319.1 - 6.5e-10 39.7 1.1 9.1e-09 36.1 0.1 2.9 3 0 0 3 3 3 1 Iron/zinc purple acid phosphatase-like protein C Pur_ac_phosph_N PF16656.5 ETO09319.1 - 9.2e-05 22.9 0.0 0.00047 20.7 0.0 2.2 2 0 0 2 2 2 1 Purple acid Phosphatase, N-terminal domain Ribosomal_S26e PF01283.19 ETO09320.1 - 6.7e-18 65.1 6.8 6.7e-18 65.1 6.8 3.1 2 2 1 3 3 3 1 Ribosomal protein S26e SelK_SelG PF10961.8 ETO09320.1 - 0.055 14.1 1.0 6.1 7.5 0.1 2.3 2 0 0 2 2 2 0 Selenoprotein SelK_SelG Ctr PF04145.15 ETO09320.1 - 0.9 10.2 3.2 3.1 8.4 0.3 2.2 2 0 0 2 2 2 0 Ctr copper transporter family MutS_III PF05192.18 ETO09322.1 - 6.5e-18 65.6 14.3 7.3e-17 62.2 11.2 2.6 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ETO09322.1 - 1.6e-05 25.2 0.2 0.00037 20.8 0.0 2.9 3 0 0 3 3 3 1 MutS domain II Mucin PF01456.17 ETO09322.1 - 0.017 15.1 12.4 0.053 13.5 10.5 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Ctr PF04145.15 ETO09322.1 - 0.035 14.7 7.0 0.97 10.0 0.1 3.1 3 0 0 3 3 3 0 Ctr copper transporter family AAR2 PF05282.11 ETO09322.1 - 0.075 12.4 10.5 0.46 9.8 2.2 2.5 2 0 0 2 2 2 0 AAR2 protein DUF3439 PF11921.8 ETO09322.1 - 0.089 12.8 7.2 0.25 11.3 7.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Striatin PF08232.12 ETO09322.1 - 0.67 10.5 22.8 0.076 13.6 2.4 3.3 3 0 0 3 3 3 0 Striatin family NST1 PF13945.6 ETO09322.1 - 5.2 7.1 48.1 0.63 10.1 5.6 3.3 3 0 0 3 3 3 0 Salt tolerance down-regulator BSP_II PF05432.11 ETO09322.1 - 7.3 6.2 29.1 0.99 9.0 2.7 3.1 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) RP-C_C PF11800.8 ETO09322.1 - 7.7 6.6 15.4 1.6 8.7 2.1 2.7 3 0 0 3 3 3 0 Replication protein C C-terminal region Kelch_1 PF01344.25 ETO09323.1 - 2.1e-07 30.4 1.1 4.4e-06 26.2 0.2 2.5 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO09323.1 - 7.6e-07 29.2 0.8 0.00024 21.3 0.1 2.3 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO09323.1 - 2.3e-06 27.5 0.1 0.003 17.5 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO09323.1 - 0.00028 20.7 0.8 0.033 14.2 0.9 2.6 2 1 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO09323.1 - 0.05 13.9 0.0 0.44 10.9 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF2434 PF10361.9 ETO09324.1 - 2.2 7.2 5.6 0.34 9.9 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2434) DnaJ PF00226.31 ETO09325.1 - 2.1e-05 24.6 5.2 2.1e-05 24.6 5.2 2.1 2 0 0 2 2 2 1 DnaJ domain DUF2207 PF09972.9 ETO09325.1 - 0.0012 17.7 0.6 0.0014 17.5 0.6 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF1980 PF09323.10 ETO09325.1 - 0.26 11.2 6.5 0.064 13.2 2.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) DnaJ_C PF01556.18 ETO09326.1 - 1.3e-27 96.8 0.0 1.5e-27 96.5 0.0 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO09326.1 - 0.099 13.0 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 DnaJ central domain rRNA_proc-arch PF13234.6 ETO09327.1 - 1.7e-54 185.6 10.0 4.5e-53 180.9 4.4 2.1 2 0 0 2 2 2 2 rRNA-processing arch domain DSHCT PF08148.12 ETO09327.1 - 7.8e-49 165.5 0.5 1.9e-48 164.3 0.5 1.6 1 0 0 1 1 1 1 DSHCT (NUC185) domain Helicase_C PF00271.31 ETO09327.1 - 6.6e-07 29.7 1.2 9.2e-06 26.0 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain P2 PF07194.11 ETO09327.1 - 0.022 14.8 0.2 3.4 7.8 0.0 2.9 3 0 0 3 3 3 0 P2 response regulator binding domain DUF1488 PF07369.11 ETO09327.1 - 0.026 14.5 0.7 0.26 11.3 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1488) PABP PF00658.18 ETO09327.1 - 0.04 14.1 0.0 0.15 12.3 0.0 2.0 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain PCRF PF03462.18 ETO09327.1 - 7.4 6.4 9.3 1.1 9.1 0.7 3.3 3 1 1 4 4 4 0 PCRF domain DUF1336 PF07059.12 ETO09328.1 - 2.4e-10 40.9 0.0 2.9e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) zf-RanBP PF00641.18 ETO09329.1 - 0.0004 19.6 6.2 0.00085 18.6 6.2 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Y2_Tnp PF04986.13 ETO09329.1 - 0.057 13.5 0.2 0.26 11.3 0.0 1.8 2 0 0 2 2 2 0 Putative transposase PdaC PF13739.6 ETO09329.1 - 3.8 8.6 7.4 1.1 10.3 3.5 1.9 2 0 0 2 2 2 0 Deacetylase PdaC DUF5082 PF16888.5 ETO09330.1 - 0.033 14.5 1.6 0.042 14.1 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) DUF1749 PF08538.10 ETO09330.1 - 0.06 12.4 0.0 0.069 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Ank_4 PF13637.6 ETO09330.1 - 0.13 12.9 0.0 0.61 10.7 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) C2 PF00168.30 ETO09331.1 - 5.5e-08 33.0 0.1 5.1e-05 23.5 0.0 2.7 2 1 1 3 3 3 2 C2 domain RasGEF PF00617.19 ETO09332.1 - 1.3e-36 126.4 6.2 1.3e-36 126.4 6.2 1.7 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ETO09333.1 - 2e-12 47.3 0.6 5.4e-12 45.9 0.1 2.0 2 0 0 2 2 2 1 RasGEF N-terminal motif RasGEF PF00617.19 ETO09333.1 - 0.00022 21.5 0.7 0.00051 20.3 0.0 1.9 2 0 0 2 2 2 1 RasGEF domain PMC2NT PF08066.12 ETO09333.1 - 0.087 13.5 0.4 0.27 12.0 0.4 1.9 1 0 0 1 1 1 0 PMC2NT (NUC016) domain SET PF00856.28 ETO09335.1 - 0.0071 16.7 0.0 0.0071 16.7 0.0 2.5 2 1 0 2 2 2 1 SET domain DUF3800 PF12686.7 ETO09336.1 - 0.029 15.0 5.9 2.6e+02 2.2 4.2 6.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3800) SAPS PF04499.15 ETO09337.1 - 0.0084 14.9 12.4 0.012 14.4 12.4 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DUF4746 PF15928.5 ETO09337.1 - 0.057 12.8 9.1 0.11 11.9 9.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RRN3 PF05327.11 ETO09337.1 - 0.076 11.5 5.9 0.12 10.9 5.9 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETO09337.1 - 0.097 10.9 10.0 0.13 10.5 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 ETO09337.1 - 0.4 10.8 5.3 1 9.6 5.3 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 ETO09337.1 - 0.52 9.6 15.6 1 8.7 15.6 1.4 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO09337.1 - 1.9 6.6 22.4 2.7 6.1 22.4 1.1 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO09337.1 - 4 6.1 8.7 7.1 5.3 8.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SDA1 PF05285.12 ETO09337.1 - 9 5.6 25.9 15 4.9 25.9 1.2 1 0 0 1 1 1 0 SDA1 Leu_Phe_trans PF03588.14 ETO09339.1 - 6.5e-09 35.5 0.1 0.00057 19.5 0.1 2.3 2 0 0 2 2 2 2 Leucyl/phenylalanyl-tRNA protein transferase Dapper PF15268.6 ETO09340.1 - 0.0024 16.8 17.8 0.0029 16.6 17.8 1.0 1 0 0 1 1 1 1 Dapper TNFR_16_TM PF18422.1 ETO09340.1 - 0.023 14.7 0.3 0.04 13.9 0.3 1.3 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain TPR_21 PF09976.9 ETO09340.1 - 0.028 14.1 0.0 0.05 13.3 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain Dicty_REP PF05086.12 ETO09340.1 - 0.078 11.0 24.1 0.099 10.6 24.1 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Utp14 PF04615.13 ETO09340.1 - 0.45 9.0 20.8 0.56 8.7 20.8 1.1 1 0 0 1 1 1 0 Utp14 protein AJAP1_PANP_C PF15298.6 ETO09340.1 - 0.62 10.2 17.2 1.2 9.3 17.2 1.6 1 0 0 1 1 1 0 AJAP1/PANP C-terminus KIAA1328 PF15369.6 ETO09340.1 - 5.5 6.7 11.8 7.6 6.3 11.8 1.3 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 WD40 PF00400.32 ETO09341.1 - 2.4e-14 53.5 8.3 0.00042 21.1 0.0 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat WD40_like PF17005.5 ETO09341.1 - 7.9e-06 25.4 3.0 0.00022 20.6 0.9 2.3 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO09341.1 - 0.0011 17.7 0.9 0.03 13.0 0.2 2.4 1 1 2 3 3 3 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09341.1 - 0.0014 18.9 0.1 0.021 15.1 0.0 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain zinc_ribbon_16 PF17034.5 ETO09342.1 - 0.43 10.8 2.9 0.4 10.9 0.3 2.2 3 0 0 3 3 3 0 Zinc-ribbon like family NicO PF03824.16 ETO09343.1 - 0.0018 17.7 0.1 0.0035 16.7 0.0 1.5 1 1 0 1 1 1 1 High-affinity nickel-transport protein FAM176 PF14851.6 ETO09343.1 - 0.073 12.7 0.0 0.14 11.8 0.0 1.4 1 0 0 1 1 1 0 FAM176 family ESSS PF10183.9 ETO09343.1 - 0.09 13.0 2.3 0.13 12.4 0.0 2.4 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) Ras PF00071.22 ETO09344.1 - 3.9e-18 65.6 0.0 6.6e-18 64.8 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO09344.1 - 5e-06 26.7 0.0 1.3e-05 25.4 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ADIP PF11559.8 ETO09345.1 - 0.0049 17.0 15.3 0.0049 17.0 15.3 6.2 3 2 4 7 7 7 2 Afadin- and alpha -actinin-Binding FlaC_arch PF05377.11 ETO09345.1 - 0.034 14.5 0.3 0.034 14.5 0.3 5.1 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 ETO09345.1 - 1.7 8.8 66.2 0.42 10.7 3.9 6.6 5 1 1 6 6 6 0 TPR/MLP1/MLP2-like protein DUF5475 PF17569.2 ETO09345.1 - 2.7 8.4 6.2 0.62 10.4 0.8 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5475) CENP-F_leu_zip PF10473.9 ETO09345.1 - 4.2 7.4 61.1 0.24 11.4 1.7 5.2 3 2 1 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TFIIF_alpha PF05793.12 ETO09346.1 - 3.5e-06 25.9 12.5 3.5e-06 25.9 12.5 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) YL1 PF05764.13 ETO09346.1 - 0.0026 17.9 18.7 0.0032 17.6 18.7 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 ETO09346.1 - 0.0036 15.7 12.6 0.0034 15.7 12.6 1.2 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO09346.1 - 0.0068 14.7 26.8 0.0078 14.5 26.8 1.1 1 0 0 1 1 1 1 Nop14-like family LTV PF04180.14 ETO09346.1 - 0.078 12.7 13.0 0.093 12.4 13.0 1.2 1 0 0 1 1 1 0 Low temperature viability protein Lin-8 PF03353.15 ETO09346.1 - 0.16 11.5 15.2 0.19 11.2 15.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CAS_C PF12026.8 ETO09346.1 - 0.23 11.6 5.0 0.29 11.2 5.0 1.3 1 0 0 1 1 1 0 Crk-Associated Substrate C-terminal domain Hamartin PF04388.12 ETO09346.1 - 0.94 8.1 12.9 1.2 7.7 12.9 1.2 1 0 0 1 1 1 0 Hamartin protein SDA1 PF05285.12 ETO09346.1 - 2 7.8 31.7 2.6 7.4 31.7 1.1 1 0 0 1 1 1 0 SDA1 DUF908 PF06012.12 ETO09346.1 - 5.1 6.4 8.3 7.3 5.9 8.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Presenilin PF01080.17 ETO09346.1 - 5.1 5.8 13.8 5.5 5.6 13.8 1.2 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO09346.1 - 7.3 5.3 17.2 9.2 4.9 17.2 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Neur_chan_memb PF02932.16 ETO09347.1 - 0.00027 21.1 1.8 0.00057 20.0 1.8 1.6 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region ECF_trnsprt PF12822.7 ETO09347.1 - 0.054 13.6 4.0 0.27 11.3 1.9 2.3 2 0 0 2 2 2 0 ECF transporter, substrate-specific component TMEM247 PF15444.6 ETO09349.1 - 0.16 12.0 0.6 0.21 11.6 0.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 SirB PF04247.12 ETO09350.1 - 0.019 15.0 3.2 0.019 15.0 3.2 1.6 1 1 0 1 1 1 0 Invasion gene expression up-regulator, SirB DUF3488 PF11992.8 ETO09350.1 - 0.022 13.7 3.4 0.028 13.4 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3488) UT PF03253.14 ETO09350.1 - 0.084 12.0 4.3 0.099 11.8 4.0 1.3 1 1 0 1 1 1 0 Urea transporter DUF5385 PF17359.2 ETO09350.1 - 0.28 10.7 2.9 0.55 9.8 2.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Ac76 PF05814.11 ETO09350.1 - 1.1 9.3 7.0 0.24 11.4 2.0 2.0 1 1 1 2 2 2 0 Orf76 (Ac76) DUF2207 PF09972.9 ETO09350.1 - 6.5 5.4 9.1 77 1.9 8.9 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) NB PF04159.13 ETO09350.1 - 9.7 6.3 10.8 15 5.7 2.4 2.2 1 1 1 2 2 2 0 NB glycoprotein DUF4652 PF15525.6 ETO09351.1 - 0.0055 16.5 3.4 0.0055 16.5 3.4 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4652) Secretin_N_2 PF07655.13 ETO09351.1 - 0.31 11.6 11.3 0.084 13.4 7.8 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain CCB1 PF12046.8 ETO09352.1 - 0.09 12.1 2.0 0.086 12.2 1.0 1.4 1 1 0 1 1 1 0 Cofactor assembly of complex C subunit B Sec62 PF03839.16 ETO09352.1 - 5.2 6.5 12.6 6.6 6.2 12.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Peptidase_C14 PF00656.22 ETO09353.1 - 1.9e-11 44.4 0.3 3.8e-11 43.4 0.3 1.7 1 1 0 1 1 1 1 Caspase domain DUF1366 PF07104.11 ETO09353.1 - 0.11 12.2 1.2 0.27 11.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) Serine_rich PF08824.10 ETO09353.1 - 0.15 12.1 2.1 0.34 10.9 2.1 1.5 1 0 0 1 1 1 0 Serine rich protein interaction domain 2-Hacid_dh PF00389.30 ETO09354.1 - 0.019 14.6 0.0 0.037 13.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain ArfGap PF01412.18 ETO09355.1 - 7.5e-32 109.9 1.5 2.5e-31 108.2 1.5 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PH PF00169.29 ETO09355.1 - 2.8e-13 50.3 2.4 1.6e-12 47.8 1.0 2.6 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO09355.1 - 5.5e-07 29.8 1.0 5.5e-07 29.8 1.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 ETO09355.1 - 1.8e-06 28.3 4.4 1.7e-05 25.2 4.4 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain Ank_5 PF13857.6 ETO09355.1 - 1.2e-05 25.5 0.1 3.1e-05 24.2 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO09355.1 - 2.9e-05 24.6 0.1 9.7e-05 22.9 0.1 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO09355.1 - 0.003 17.9 0.1 0.018 15.5 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ETO09355.1 - 0.0056 17.1 0.1 0.037 14.5 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeat PH_9 PF15410.6 ETO09355.1 - 0.13 12.7 2.5 0.62 10.4 0.3 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain Corona_NS1 PF06145.11 ETO09355.1 - 0.21 11.1 0.4 17 5.0 0.0 2.5 2 0 0 2 2 2 0 Coronavirus nonstructural protein NS1 DENN PF02141.21 ETO09356.1 - 3.4e-17 63.0 0.6 6.5e-11 42.5 0.1 2.2 2 0 0 2 2 2 2 DENN (AEX-3) domain PDGF PF00341.17 ETO09357.1 - 0.022 15.0 0.1 0.054 13.8 0.1 1.6 1 0 0 1 1 1 0 PDGF/VEGF domain DUF3395 PF11875.8 ETO09358.1 - 1.3 8.9 5.3 0.57 10.1 0.5 2.7 2 1 1 4 4 4 0 Domain of unknown function (DUF3395) Rimk_N PF18030.1 ETO09359.1 - 0.056 13.8 0.0 2.1 8.8 0.0 2.3 2 0 0 2 2 2 0 RimK PreATP-grasp domain Ank_2 PF12796.7 ETO09360.1 - 0.00051 20.6 0.1 0.041 14.5 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO09360.1 - 0.0073 16.7 1.2 25 5.9 0.0 3.7 3 0 0 3 3 3 0 Ankyrin repeat Ank_4 PF13637.6 ETO09360.1 - 0.026 15.1 0.2 3.3 8.4 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) SOBP PF15279.6 ETO09360.1 - 0.077 13.6 8.3 0.12 13.0 8.3 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Ank PF00023.30 ETO09360.1 - 0.24 11.9 1.4 8.4 7.0 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat SMYLE_N PF18615.1 ETO09360.1 - 0.44 10.1 14.4 0.6 9.6 14.4 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Mog1 PF04603.12 ETO09360.1 - 0.78 10.1 8.2 0.073 13.4 3.3 1.8 2 0 0 2 2 2 0 Ran-interacting Mog1 protein CCDC106 PF15794.5 ETO09360.1 - 1.9 8.2 13.5 0.51 10.0 8.8 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SLC12 PF03522.15 ETO09360.1 - 6.3 5.7 22.6 54 2.6 22.6 2.2 1 1 0 1 1 1 0 Solute carrier family 12 YlzJ PF14035.6 ETO09360.1 - 7.5 6.8 5.9 2.7 8.3 0.7 2.6 2 0 0 2 2 2 0 YlzJ-like protein Macoilin PF09726.9 ETO09361.1 - 0.082 11.5 8.3 0.089 11.3 8.3 1.1 1 0 0 1 1 1 0 Macoilin family Miga PF10265.9 ETO09361.1 - 0.13 11.2 7.3 0.16 10.9 7.3 1.1 1 0 0 1 1 1 0 Mitoguardin Apt1 PF10351.9 ETO09361.1 - 0.23 10.3 5.9 0.25 10.2 5.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ETO09361.1 - 0.27 11.1 8.9 0.3 10.9 8.9 1.1 1 0 0 1 1 1 0 SPX domain DUF2632 PF10943.8 ETO09361.1 - 0.54 9.8 2.8 0.87 9.1 2.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2632) PAP1 PF08601.10 ETO09361.1 - 0.88 9.2 15.6 1 9.0 15.6 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 zf-C2H2 PF00096.26 ETO09362.1 - 1.6e-05 25.1 6.2 0.0039 17.6 0.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO09362.1 - 3.3e-05 24.1 10.6 6e-05 23.3 2.2 2.6 2 0 0 2 2 2 1 Zinc-finger double domain zf-Di19 PF05605.12 ETO09362.1 - 0.00013 22.2 2.6 0.00026 21.2 2.6 1.5 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ETO09362.1 - 0.00019 22.0 8.2 0.0033 18.1 0.2 3.0 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ETO09362.1 - 0.0015 18.2 0.0 0.0035 17.1 0.0 1.6 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-met PF12874.7 ETO09362.1 - 0.02 15.3 4.4 0.56 10.7 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ETO09362.1 - 0.027 14.8 5.7 0.72 10.2 0.1 3.0 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding Methyltransf_12 PF08242.12 ETO09362.1 - 2.2 9.1 5.1 39 5.1 0.1 2.9 2 0 0 2 2 2 0 Methyltransferase domain DHC_N1 PF08385.12 ETO09365.1 - 2.1e-23 82.8 1.2 2.5e-23 82.5 1.2 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DHC_N1 PF08385.12 ETO09366.1 - 9.8e-40 136.7 1.6 1.1e-39 136.6 1.6 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 BACK PF07707.15 ETO09366.1 - 0.024 14.7 1.0 0.039 14.1 1.0 1.4 1 0 0 1 1 1 0 BTB And C-terminal Kelch Orthopox_A49R PF06489.11 ETO09366.1 - 0.095 12.9 0.8 0.18 12.1 0.6 1.5 1 1 0 1 1 1 0 Orthopoxvirus A49R protein IBR PF01485.21 ETO09367.1 - 0.0086 16.3 5.0 0.028 14.7 5.0 1.9 1 1 0 1 1 1 1 IBR domain, a half RING-finger domain DUF2981 PF11200.8 ETO09368.1 - 3.2 7.4 11.3 3.7 7.2 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Macoilin PF09726.9 ETO09368.1 - 7.7 4.9 20.8 7.7 4.9 20.8 1.0 1 0 0 1 1 1 0 Macoilin family DUF4398 PF14346.6 ETO09369.1 - 0.11 13.2 2.9 1.9 9.1 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4398) DUF4407 PF14362.6 ETO09369.1 - 9.2 5.5 9.5 10 5.4 9.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MatE PF01554.18 ETO09371.1 - 0.17 11.5 10.4 1.3 8.7 9.9 2.2 1 1 0 1 1 1 0 MatE CDC45 PF02724.14 ETO09372.1 - 0.0074 14.6 9.7 0.0093 14.3 9.7 1.0 1 0 0 1 1 1 1 CDC45-like protein DUF2052 PF09747.9 ETO09372.1 - 0.011 15.9 11.3 0.013 15.7 11.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Connexin PF00029.19 ETO09372.1 - 0.015 15.1 1.7 0.015 15.1 1.7 1.5 2 0 0 2 2 2 0 Connexin RR_TM4-6 PF06459.12 ETO09372.1 - 0.037 13.9 7.3 0.038 13.8 7.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt5_N PF11942.8 ETO09372.1 - 0.046 14.7 11.0 0.067 14.2 11.0 1.2 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal MatE PF01554.18 ETO09372.1 - 0.066 12.9 0.2 0.09 12.4 0.2 1.1 1 0 0 1 1 1 0 MatE Tim54 PF11711.8 ETO09372.1 - 0.4 9.4 7.7 0.49 9.1 7.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO09372.1 - 0.42 9.8 3.1 0.46 9.6 3.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Nop53 PF07767.11 ETO09372.1 - 0.54 9.6 18.3 0.62 9.4 18.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TP53IP5 PF15331.6 ETO09372.1 - 0.73 9.9 8.0 24 5.0 7.6 2.0 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 DUF913 PF06025.12 ETO09372.1 - 4 6.3 5.4 5.2 5.9 5.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 ETO09372.1 - 9.6 4.2 10.9 11 4.0 10.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi PIH1 PF08190.12 ETO09373.1 - 1.9e-15 56.7 0.3 3.9e-15 55.7 0.3 1.5 1 0 0 1 1 1 1 PIH1 N-terminal domain cNMP_binding PF00027.29 ETO09374.1 - 8.9e-05 22.5 0.0 0.00018 21.5 0.0 1.4 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain Phospholip_B PF04916.13 ETO09375.1 - 3e-69 234.0 5.4 3.6e-69 233.7 5.4 1.0 1 0 0 1 1 1 1 Phospholipase B Phospholip_B PF04916.13 ETO09376.1 - 7.2e-43 146.9 0.7 9.2e-43 146.6 0.7 1.1 1 0 0 1 1 1 1 Phospholipase B DUF4914 PF16260.5 ETO09376.1 - 0.021 13.0 0.0 0.029 12.5 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4914) DUF1798 PF08807.10 ETO09376.1 - 0.14 12.3 0.1 0.27 11.4 0.1 1.4 1 0 0 1 1 1 0 Bacterial domain of unknown function (DUF1798) EF-hand_6 PF13405.6 ETO09377.1 - 3.5e-21 73.3 3.4 1.7e-08 33.7 0.3 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_1 PF00036.32 ETO09377.1 - 3.2e-20 70.1 11.1 1.3e-07 30.6 0.6 4.2 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO09377.1 - 3.9e-18 65.7 9.2 1.2e-08 35.3 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO09377.1 - 6.6e-13 47.5 10.5 4e-07 29.2 0.0 3.6 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ETO09377.1 - 1.2e-10 41.1 13.6 0.00038 20.3 0.7 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ETO09377.1 - 1.3e-05 25.4 0.2 0.19 12.1 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO09377.1 - 1.5e-05 25.3 1.7 0.046 14.1 0.0 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 ETO09377.1 - 2.1e-05 24.5 0.0 0.025 14.5 0.0 2.9 2 1 1 3 3 3 2 Caleosin related protein Dockerin_1 PF00404.18 ETO09377.1 - 3.1e-05 24.1 2.9 0.0013 18.9 0.6 3.4 3 1 0 3 3 3 1 Dockerin type I domain UvrA_inter PF17760.1 ETO09377.1 - 0.013 15.6 0.8 0.027 14.5 0.4 1.9 1 1 1 2 2 2 0 UvrA interaction domain EF-hand_4 PF12763.7 ETO09377.1 - 0.04 13.9 4.4 0.4 10.7 0.5 2.6 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Arm PF00514.23 ETO09378.1 - 3.3e-12 46.0 0.1 4.8e-05 23.3 0.0 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat Podoplanin PF05808.11 ETO09379.1 - 1.7e-09 38.0 0.1 2.8e-09 37.3 0.1 1.3 1 0 0 1 1 1 1 Podoplanin TMEM154 PF15102.6 ETO09379.1 - 6.9e-06 26.0 0.3 1.3e-05 25.1 0.0 1.6 2 0 0 2 2 2 1 TMEM154 protein family DUF2207 PF09972.9 ETO09379.1 - 0.0048 15.7 0.0 0.0058 15.4 0.0 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 ETO09379.1 - 0.018 15.9 0.0 0.048 14.5 0.0 1.7 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain BatD PF13584.6 ETO09379.1 - 0.022 13.6 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance Glycophorin_A PF01102.18 ETO09379.1 - 0.058 13.6 0.0 0.11 12.7 0.0 1.5 1 0 0 1 1 1 0 Glycophorin A SIT PF15330.6 ETO09379.1 - 0.09 13.2 0.1 0.26 11.7 0.1 1.8 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Epiglycanin_C PF14654.6 ETO09379.1 - 0.25 11.4 2.1 0.51 10.4 2.0 1.6 1 1 0 1 1 1 0 Mucin, catalytic, TM and cytoplasmic tail region LapA_dom PF06305.11 ETO09379.1 - 0.48 10.3 4.4 1.1 9.1 4.4 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SKG6 PF08693.10 ETO09379.1 - 6.2 6.3 7.7 18 4.9 7.7 1.8 1 0 0 1 1 1 0 Transmembrane alpha-helix domain Tubulin PF00091.25 ETO09380.1 - 5.3e-65 219.3 0.0 8.9e-65 218.6 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO09380.1 - 1.7e-36 125.2 0.1 2.9e-36 124.4 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO09380.1 - 0.088 13.1 0.0 0.15 12.4 0.0 1.3 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain PGM_PMM_II PF02879.16 ETO09380.1 - 0.13 12.9 0.0 2.2 9.0 0.0 2.8 3 0 0 3 3 3 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II ABC2_membrane PF01061.24 ETO09381.1 - 5.7e-15 55.3 19.0 5.7e-15 55.3 19.0 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC_tran PF00005.27 ETO09381.1 - 3.2e-07 31.0 0.8 6.5e-07 29.9 0.0 1.8 2 0 0 2 2 2 1 ABC transporter Pox_A14 PF05767.12 ETO09381.1 - 5.5 7.2 8.1 4.5 7.5 5.1 2.3 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 AAA_29 PF13555.6 ETO09382.1 - 0.002 17.8 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO09382.1 - 0.0053 17.0 0.4 0.04 14.2 0.1 2.4 1 1 1 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETO09382.1 - 0.0064 16.4 0.0 0.015 15.2 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ETO09382.1 - 0.01 16.2 0.4 0.03 14.7 0.1 2.1 2 1 0 2 2 2 0 AAA ATPase domain Microtub_bd PF16796.5 ETO09382.1 - 0.015 15.2 0.4 0.076 12.9 0.1 2.2 2 0 0 2 2 2 0 Microtubule binding IstB_IS21 PF01695.17 ETO09382.1 - 0.016 15.0 0.0 0.029 14.1 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein ABC_tran PF00005.27 ETO09382.1 - 0.029 14.9 0.8 0.029 14.9 0.8 2.1 1 1 1 2 2 2 0 ABC transporter PduV-EutP PF10662.9 ETO09382.1 - 0.044 13.5 0.0 0.092 12.5 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Hydin_ADK PF17213.3 ETO09383.1 - 7.2 6.8 6.7 2.1 8.6 2.7 2.0 1 1 1 2 2 2 0 Hydin Adenylate kinase-like domain YMF19 PF02326.15 ETO09383.1 - 8.4 7.3 7.6 0.51 11.1 1.2 2.2 3 0 0 3 3 3 0 Plant ATP synthase F0 TLD PF07534.16 ETO09384.1 - 2.3e-09 37.6 0.0 6.6e-09 36.1 0.0 1.8 1 0 0 1 1 1 1 TLD COG2 PF06148.11 ETO09384.1 - 0.0053 16.9 3.2 0.01 15.9 3.2 1.4 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 Occludin_ELL PF07303.13 ETO09384.1 - 0.057 14.1 8.4 0.15 12.8 8.4 1.7 1 0 0 1 1 1 0 Occludin homology domain Csm1_B PF18211.1 ETO09384.1 - 0.11 12.4 0.8 0.32 10.9 0.0 2.1 2 0 0 2 2 2 0 Csm1 subunit domain B DUF1967 PF09269.11 ETO09384.1 - 0.12 12.4 1.0 27 4.8 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) Med4 PF10018.9 ETO09384.1 - 0.16 11.6 5.3 0.33 10.6 5.3 1.6 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 TPR_MLP1_2 PF07926.12 ETO09384.1 - 0.18 11.9 6.4 0.1 12.6 3.4 1.7 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF3042 PF11240.8 ETO09384.1 - 0.22 11.5 0.5 0.61 10.1 0.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3042) XhlA PF10779.9 ETO09384.1 - 0.26 11.5 4.2 0.38 11.0 2.2 2.5 1 1 1 2 2 2 0 Haemolysin XhlA RNA_pol_Rpb1_5 PF04998.17 ETO09384.1 - 7.2 6.0 8.9 16 4.9 8.9 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Ureide_permease PF07168.11 ETO09385.1 - 0.0038 16.0 0.4 0.0051 15.6 0.4 1.3 1 0 0 1 1 1 1 Ureide permease Cation_ATPase_C PF00689.21 ETO09386.1 - 8.4e-45 152.7 8.9 8.4e-45 152.7 8.9 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETO09386.1 - 3.1e-20 73.4 0.0 5.4e-20 72.6 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO09386.1 - 1.5e-15 57.1 0.0 3.2e-15 56.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETO09386.1 - 1.4e-09 38.1 1.4 1.7e-06 27.9 0.7 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO09386.1 - 3.5e-07 30.8 0.1 4.2e-06 27.3 0.0 2.6 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETO09386.1 - 0.0056 16.8 0.0 0.031 14.4 0.0 2.3 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase GHL6 PF14871.6 ETO09386.1 - 0.14 12.3 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase 6 cNMP_binding PF00027.29 ETO09387.1 - 3.1e-50 168.2 0.1 1.3e-18 66.8 0.0 3.3 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 ETO09387.1 - 0.013 15.2 0.0 12 5.7 0.0 3.1 3 0 0 3 3 3 0 Cupin domain Pkinase PF00069.25 ETO09388.1 - 4.7e-15 55.7 0.6 6.3e-15 55.2 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09388.1 - 2.8e-06 26.8 0.1 4.5e-06 26.1 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase PAD_M PF08527.10 ETO09388.1 - 0.044 13.4 0.0 0.07 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain FH2 PF02181.23 ETO09389.1 - 2.3e-67 227.7 13.1 2.3e-67 227.7 13.1 1.8 1 1 1 2 2 2 1 Formin Homology 2 Domain FlaC_arch PF05377.11 ETO09389.1 - 6.5 7.2 15.1 0.094 13.1 1.0 4.3 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) GlcNAc-1_reg PF18440.1 ETO09390.1 - 0.092 13.0 0.9 1.9 8.8 0.3 2.4 1 1 1 2 2 2 0 Putative GlcNAc-1 phosphotransferase regulatory domain SWIRM-assoc_2 PF16496.5 ETO09391.1 - 2.2 7.1 11.5 2.8 6.7 11.5 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal RhoGAP PF00620.27 ETO09392.1 - 5.6e-19 68.5 0.1 1.1e-18 67.5 0.1 1.5 1 0 0 1 1 1 1 RhoGAP domain Nop14 PF04147.12 ETO09392.1 - 0.0014 16.9 27.4 0.0014 16.9 27.4 1.6 2 0 0 2 2 2 1 Nop14-like family Utp14 PF04615.13 ETO09392.1 - 0.021 13.4 24.0 0.058 12.0 24.0 1.6 1 1 0 1 1 1 0 Utp14 protein IFT57 PF10498.9 ETO09392.1 - 0.32 9.9 16.1 0.74 8.7 16.1 1.6 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 SDA1 PF05285.12 ETO09392.1 - 1.4 8.3 38.3 0.3 10.5 32.8 2.1 2 0 0 2 2 2 0 SDA1 Zip PF02535.22 ETO09392.1 - 1.7 7.8 7.7 0.11 11.7 2.1 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Arm PF00514.23 ETO09393.1 - 0.00074 19.5 2.4 6.9 6.9 0.0 5.5 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat MMS19_N PF14500.6 ETO09393.1 - 0.0066 16.1 0.5 0.049 13.2 0.2 2.2 2 0 0 2 2 2 1 Dos2-interacting transcription regulator of RNA-Pol-II HEAT_2 PF13646.6 ETO09393.1 - 0.027 14.8 0.0 0.29 11.5 0.0 2.6 2 1 1 3 3 3 0 HEAT repeats PWI PF01480.17 ETO09393.1 - 0.085 13.2 0.5 0.28 11.5 0.1 2.1 2 0 0 2 2 2 0 PWI domain Cnd1 PF12717.7 ETO09393.1 - 0.41 10.7 5.1 2 8.5 1.1 3.2 1 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 V-ATPase_H_C PF11698.8 ETO09393.1 - 0.58 10.3 5.5 1.6 8.9 0.2 3.9 2 1 2 5 5 5 0 V-ATPase subunit H TauE PF01925.19 ETO09394.1 - 9.1e-05 22.2 6.1 9.1e-05 22.2 6.1 1.8 2 1 0 2 2 2 1 Sulfite exporter TauE/SafE DUF3959 PF13105.6 ETO09394.1 - 0.097 12.2 3.7 0.73 9.3 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) DUF3169 PF11368.8 ETO09394.1 - 0.19 11.2 0.0 0.19 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DnaB_2 PF07261.11 ETO09396.1 - 0.0017 18.1 0.5 0.12 12.2 0.0 2.7 2 1 1 3 3 3 2 Replication initiation and membrane attachment Arteri_env PF01606.16 ETO09396.1 - 0.043 13.7 0.1 0.062 13.2 0.1 1.2 1 0 0 1 1 1 0 Arterivirus envelope protein Methyltransf_3 PF01596.17 ETO09398.1 - 3.9e-58 196.1 0.4 5e-58 195.8 0.4 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ETO09398.1 - 2.3e-12 47.9 0.0 3.8e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO09398.1 - 9.2e-06 25.5 0.0 1.4e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO09398.1 - 4.9e-05 24.0 0.0 0.0001 23.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Spermine_synth PF01564.17 ETO09398.1 - 0.00064 19.2 0.2 0.0059 16.0 0.2 2.2 1 1 1 2 2 2 1 Spermine/spermidine synthase domain CMAS PF02353.20 ETO09398.1 - 0.0012 18.2 0.0 0.0016 17.8 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Cons_hypoth95 PF03602.15 ETO09398.1 - 0.0014 18.3 0.0 0.0022 17.6 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 GCD14 PF08704.10 ETO09398.1 - 0.0017 18.1 0.0 0.0027 17.4 0.0 1.3 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit Methyltransf_18 PF12847.7 ETO09398.1 - 0.0033 17.4 0.0 0.0062 16.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO09398.1 - 0.0052 17.4 0.0 0.012 16.3 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO09398.1 - 0.013 16.3 0.0 0.036 14.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ETO09398.1 - 0.014 15.1 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Ubie_methyltran PF01209.18 ETO09398.1 - 0.039 13.3 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family TrmK PF04816.12 ETO09398.1 - 0.063 12.8 0.0 0.13 11.8 0.0 1.5 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase Myc_target_1 PF15179.6 ETO09399.1 - 0.0021 18.0 0.0 0.0021 18.0 0.0 2.7 2 0 0 2 2 2 1 Myc target protein 1 DUF4381 PF14316.6 ETO09399.1 - 0.0023 18.2 0.0 1.8 8.8 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4381) FAM176 PF14851.6 ETO09399.1 - 0.0092 15.6 0.1 0.0092 15.6 0.1 3.7 3 2 1 4 4 4 1 FAM176 family GAPT PF11770.8 ETO09399.1 - 0.016 15.0 0.0 0.016 15.0 0.0 2.5 3 0 0 3 3 3 0 GRB2-binding adapter (GAPT) DUF4023 PF13215.6 ETO09399.1 - 0.02 14.9 3.9 0.02 14.9 3.9 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4023) Ac76 PF05814.11 ETO09399.1 - 0.056 13.5 2.0 0.086 12.9 0.2 2.1 2 0 0 2 2 2 0 Orf76 (Ac76) Conotoxin PF02950.17 ETO09399.1 - 0.062 14.3 0.8 0.062 14.3 0.8 3.1 4 0 0 4 4 4 0 Conotoxin OAD_gamma PF04277.13 ETO09399.1 - 0.14 12.8 0.2 1 10.0 0.0 2.6 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF4834 PF16118.5 ETO09399.1 - 0.43 11.6 0.0 0.43 11.6 0.0 3.9 4 1 0 4 4 4 0 Domain of unknown function (DUF4834) CRA PF06589.11 ETO09399.1 - 2.9 8.0 8.6 0.44 10.6 0.1 3.2 3 0 0 3 3 3 0 Circumsporozoite-related antigen (CRA) MRG PF05712.13 ETO09400.1 - 3.7e-15 55.8 0.6 1.3e-14 53.9 0.6 2.0 1 1 0 1 1 1 1 MRG Connexin PF00029.19 ETO09401.1 - 0.036 13.8 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 ETO09401.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DNA_pol_phi PF04931.13 ETO09401.1 - 0.27 9.3 4.2 0.49 8.4 4.2 1.5 1 1 0 1 1 1 0 DNA polymerase phi Orf78 PF06024.12 ETO09401.1 - 0.4 11.0 2.1 1.2 9.5 2.0 1.9 1 1 0 1 1 1 0 Orf78 (ac78) RGS PF00615.19 ETO09402.1 - 0.085 13.1 6.3 0.085 13.1 2.7 3.1 2 1 0 2 2 2 0 Regulator of G protein signaling domain Ion_trans PF00520.31 ETO09402.1 - 0.54 9.4 8.8 5 6.3 0.1 3.3 3 0 0 3 3 3 0 Ion transport protein DHHC PF01529.20 ETO09403.1 - 1.8e-25 89.6 22.5 1.8e-25 89.6 22.5 2.5 2 0 0 2 2 2 1 DHHC palmitoyltransferase tRNA-synt_His PF13393.6 ETO09404.1 - 1.2e-06 28.0 0.0 1.5e-06 27.7 0.0 1.1 1 0 0 1 1 1 1 Histidyl-tRNA synthetase AP3D1 PF06375.11 ETO09404.1 - 0.22 11.8 12.5 0.42 10.9 12.5 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 FAM176 PF14851.6 ETO09404.1 - 0.49 10.0 3.9 0.67 9.6 3.9 1.4 1 0 0 1 1 1 0 FAM176 family U79_P34 PF03064.16 ETO09404.1 - 2.7 7.3 14.8 3.7 6.9 14.8 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 CRA PF06589.11 ETO09404.1 - 7.2 6.7 15.3 2 8.5 11.9 1.7 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) Ldh_1_C PF02866.18 ETO09405.1 - 2.7e-27 95.7 0.1 4.1e-27 95.1 0.1 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ETO09405.1 - 1.8e-26 92.9 0.0 2.6e-17 63.2 0.0 2.4 2 0 0 2 2 2 2 lactate/malate dehydrogenase, NAD binding domain Pkinase PF00069.25 ETO09406.1 - 5.1e-30 104.7 0.0 7.4e-30 104.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09406.1 - 3.6e-06 26.4 0.1 7.2e-06 25.5 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase CMAS PF02353.20 ETO09409.1 - 2.6e-25 89.2 0.1 3.8e-25 88.7 0.1 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_11 PF08241.12 ETO09409.1 - 7.9e-05 23.2 0.0 0.00013 22.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO09409.1 - 0.0018 19.0 0.0 0.0036 18.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO09409.1 - 0.0022 18.7 0.0 0.0039 17.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain ADH_zinc_N PF00107.26 ETO09409.1 - 0.1 12.6 0.1 0.55 10.2 0.1 2.0 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Pkinase PF00069.25 ETO09411.1 - 7.8e-26 91.0 0.0 9e-26 90.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09411.1 - 3.3e-07 29.8 0.0 4.4e-07 29.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO09411.1 - 0.027 13.8 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 Kinase-like CTP_transf_like PF01467.26 ETO09412.1 - 7.6e-09 35.9 0.5 4.8e-08 33.3 0.5 2.2 1 1 0 1 1 1 1 Cytidylyltransferase-like OTOS PF15182.6 ETO09412.1 - 0.028 14.4 0.0 0.16 11.9 0.0 2.3 3 0 0 3 3 3 0 Otospiralin RasGAP PF00616.19 ETO09413.1 - 4.8e-09 36.2 1.0 7.7e-09 35.6 0.1 1.7 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase BLUF PF04940.12 ETO09413.1 - 0.066 13.3 0.0 0.14 12.3 0.0 1.6 1 0 0 1 1 1 0 Sensors of blue-light using FAD RasGAP PF00616.19 ETO09414.1 - 1.1e-28 100.3 0.0 4.5e-28 98.4 0.0 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase SpoIIIAH PF12685.7 ETO09414.1 - 0.024 14.5 3.1 0.037 13.8 3.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein PID PF00640.23 ETO09415.1 - 0.075 13.1 2.0 0.22 11.6 2.0 1.7 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF4685 PF15737.5 ETO09415.1 - 0.13 12.7 2.8 0.93 9.9 1.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) Lipocalin_4 PF13648.6 ETO09415.1 - 1.4 9.9 7.7 1.1 10.3 0.2 2.3 2 0 0 2 2 2 0 Lipocalin-like domain Spore_II_R PF09551.10 ETO09415.1 - 2.1 8.8 5.8 0.81 10.2 2.9 1.8 2 1 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) DUF3480 PF11979.8 ETO09417.1 - 0.37 9.7 3.7 0.5 9.3 3.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3480) BNIP2 PF12496.8 ETO09417.1 - 0.83 10.1 7.1 0.19 12.2 4.1 1.4 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 adh_short_C2 PF13561.6 ETO09418.1 - 6.2e-25 88.1 0.0 1.3e-24 87.1 0.0 1.5 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO09418.1 - 5.9e-08 32.4 0.0 9.2e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase TATR PF03430.13 ETO09419.1 - 0.019 13.4 0.0 0.019 13.4 0.0 1.1 1 0 0 1 1 1 0 Trans-activating transcriptional regulator HTH_16 PF12645.7 ETO09419.1 - 0.1 12.7 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain Zip PF02535.22 ETO09420.1 - 1.1 8.4 7.0 1.9 7.6 7.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter His_Phos_1 PF00300.22 ETO09421.1 - 1.7e-10 41.0 0.1 0.056 13.1 0.0 4.0 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) Sulfatase PF00884.23 ETO09422.1 - 0.00019 21.0 0.2 0.00053 19.5 0.0 1.7 2 0 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 ETO09422.1 - 0.1 12.8 1.0 0.19 12.0 0.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4976) DUF2981 PF11200.8 ETO09423.1 - 0.0076 16.0 3.7 0.01 15.6 3.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2981) Sigma_reg_N PF13800.6 ETO09423.1 - 0.052 13.8 2.7 0.19 12.0 2.7 2.0 1 0 0 1 1 1 0 Sigma factor regulator N-terminal DUF5523 PF17661.1 ETO09423.1 - 0.18 11.5 12.4 0.25 11.0 12.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SR-25 PF10500.9 ETO09423.1 - 2.2 7.8 29.9 3.3 7.3 29.9 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Macoilin PF09726.9 ETO09423.1 - 4.3 5.8 21.9 5.4 5.4 21.9 1.1 1 0 0 1 1 1 0 Macoilin family VIR_N PF15912.5 ETO09423.1 - 5.7 6.5 9.4 9.7 5.7 9.4 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Pkinase PF00069.25 ETO09424.1 - 1.2e-10 41.2 0.1 2e-10 40.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Cellulose_synt PF03552.14 ETO09425.1 - 0.39 9.1 4.5 0.47 8.9 4.5 1.0 1 0 0 1 1 1 0 Cellulose synthase Plasmodium_Vir PF05795.11 ETO09425.1 - 0.76 9.1 10.7 0.85 9.0 10.7 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TMEM119 PF15724.5 ETO09425.1 - 2.3 8.2 6.7 2.7 8.0 6.7 1.1 1 0 0 1 1 1 0 TMEM119 family MAP17 PF15807.5 ETO09425.1 - 9.5 6.5 9.8 16 5.8 9.8 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FAM117 PF15388.6 ETO09426.1 - 0.031 13.7 1.4 0.052 13.0 1.4 1.3 1 0 0 1 1 1 0 Protein Family FAM117 KilA-N PF04383.13 ETO09426.1 - 0.83 9.5 8.1 0.42 10.5 1.1 2.3 1 1 1 2 2 2 0 KilA-N domain Sec8_exocyst PF04048.14 ETO09427.1 - 9.9e-07 28.7 0.8 7.4e-06 25.9 0.8 2.4 1 1 0 1 1 1 1 Sec8 exocyst complex component specific domain RRM_1 PF00076.22 ETO09431.1 - 4.3e-33 113.0 3.9 3.2e-12 46.1 0.0 3.8 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO09431.1 - 9.2e-05 22.5 0.9 1.5 9.0 0.0 4.1 4 0 0 4 4 4 2 RNA recognition motif RRM_3 PF08777.11 ETO09431.1 - 0.00093 19.2 3.7 2.3 8.3 0.0 3.8 3 1 0 3 3 3 2 RNA binding motif Nup35_RRM_2 PF14605.6 ETO09431.1 - 0.014 15.4 2.6 6.3 6.9 0.0 3.3 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif Viral_Rep PF02407.16 ETO09431.1 - 0.046 14.0 0.2 5.2 7.4 0.0 3.1 2 0 0 2 2 2 0 Putative viral replication protein VID27 PF08553.10 ETO09432.1 - 2.8e-69 233.9 0.1 3.1e-69 233.7 0.1 1.0 1 0 0 1 1 1 1 VID27 C-terminal WD40-like domain WD40 PF00400.32 ETO09432.1 - 0.0033 18.2 0.1 0.35 11.8 0.0 3.0 3 0 0 3 3 3 1 WD domain, G-beta repeat Cytochrom_D1 PF02239.16 ETO09432.1 - 0.0064 15.1 0.0 0.01 14.4 0.0 1.2 1 0 0 1 1 1 1 Cytochrome D1 heme domain CDC45 PF02724.14 ETO09433.1 - 0.046 12.0 9.3 0.048 12.0 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO09433.1 - 0.11 10.6 18.1 0.13 10.5 18.1 1.0 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ETO09433.1 - 0.14 11.5 16.5 0.16 11.3 16.5 1.3 1 0 0 1 1 1 0 NOA36 protein PTPRCAP PF15713.5 ETO09433.1 - 0.25 11.6 10.6 0.48 10.7 10.6 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TRAP_alpha PF03896.16 ETO09433.1 - 0.84 8.8 7.8 0.37 10.0 5.6 1.5 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO09433.1 - 1 7.4 23.3 5.8 4.9 20.1 2.0 2 0 0 2 2 2 0 DNA polymerase phi BUD22 PF09073.10 ETO09433.1 - 1.3 8.3 12.3 1.5 8.1 12.3 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ETO09433.1 - 1.4 8.2 16.1 1.6 8.0 16.1 1.1 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.6 ETO09433.1 - 1.7 8.3 8.8 3.3 7.3 8.8 1.5 1 0 0 1 1 1 0 FAM176 family CPSF100_C PF13299.6 ETO09433.1 - 5.3 7.2 7.0 6.5 6.9 6.9 1.3 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CobT PF06213.12 ETO09433.1 - 7.1 5.9 14.5 11 5.3 14.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_1B_p101 PF10486.9 ETO09433.1 - 9.4 3.9 9.5 11 3.7 9.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2722 PF10846.8 ETO09433.1 - 9.7 5.0 11.3 12 4.7 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CSN5_C PF18323.1 ETO09435.1 - 0.04 14.8 1.8 0.04 14.8 1.8 2.7 2 1 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain Myc_N PF01056.18 ETO09436.1 - 0.073 13.0 1.4 0.095 12.6 1.4 1.1 1 0 0 1 1 1 0 Myc amino-terminal region WD40 PF00400.32 ETO09438.1 - 9.3e-51 168.7 22.4 1.6e-09 38.2 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09438.1 - 1.8e-15 57.0 5.4 0.025 14.9 0.0 5.5 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO09438.1 - 6e-09 36.1 6.2 1.9e-05 24.6 0.1 4.0 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO09438.1 - 8.9e-08 31.5 2.2 0.017 14.1 0.1 4.5 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09438.1 - 1.1e-07 31.5 4.5 0.0014 18.0 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO09438.1 - 1.6e-06 27.9 1.6 6.6 6.8 0.0 5.5 6 0 0 6 6 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO09438.1 - 8.1e-06 24.8 5.5 1.7 7.2 0.1 4.3 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO09438.1 - 9.3e-06 24.4 0.8 0.029 12.9 0.1 3.2 1 1 1 3 3 3 3 Cytochrome D1 heme domain SGL PF08450.12 ETO09438.1 - 3.1e-05 23.7 0.4 0.033 13.8 0.1 2.7 2 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Resistin PF06954.11 ETO09438.1 - 0.0025 18.3 0.2 1.9 9.1 0.0 3.5 3 1 1 4 4 4 1 Resistin PALB2_WD40 PF16756.5 ETO09438.1 - 0.0037 16.2 3.0 0.45 9.4 0.0 3.6 1 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain UPF0179 PF03684.13 ETO09438.1 - 1.3 8.9 4.6 1 9.2 0.1 2.6 2 1 0 3 3 3 0 Uncharacterised protein family (UPF0179) WD40 PF00400.32 ETO09439.1 - 2.1e-11 44.1 5.6 7.1e-09 36.2 0.5 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO09439.1 - 0.0036 16.0 0.0 0.0045 15.7 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09439.1 - 0.0044 17.3 0.0 0.0082 16.4 0.0 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain IU_nuc_hydro PF01156.19 ETO09440.1 - 2.2e-14 53.7 0.0 2.5e-14 53.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase DUF3591 PF12157.8 ETO09442.1 - 9.8e-41 139.8 1.8 5.5e-29 101.1 0.3 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF3591) XK-related PF09815.9 ETO09443.1 - 0.01 15.0 0.2 0.014 14.5 0.2 1.3 1 0 0 1 1 1 0 XK-related protein Baculo_gp64 PF03273.13 ETO09443.1 - 0.056 12.3 0.1 0.071 11.9 0.1 1.1 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family NDK PF00334.19 ETO09443.1 - 0.092 12.8 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Nucleoside diphosphate kinase INCENP_N PF12178.8 ETO09443.1 - 0.37 10.8 1.3 0.65 10.0 0.1 2.1 3 0 0 3 3 3 0 Chromosome passenger complex (CPC) protein INCENP N terminal SAM_2 PF07647.17 ETO09444.1 - 0.0002 21.4 0.1 0.00038 20.5 0.1 1.4 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO09444.1 - 0.0071 16.8 0.1 0.013 16.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Lipase_GDSL PF00657.22 ETO09444.1 - 0.085 12.8 0.0 0.094 12.7 0.0 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase RabGAP-TBC PF00566.18 ETO09445.1 - 2.5e-22 79.6 0.4 3e-22 79.4 0.4 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF1201 PF06716.11 ETO09448.1 - 0.98 9.5 10.9 9.7 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) PRK PF00485.18 ETO09450.1 - 0.0023 17.7 0.0 0.0029 17.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family CagY_M PF07337.11 ETO09452.1 - 0.18 11.5 2.1 0.4 10.3 2.1 1.6 1 0 0 1 1 1 0 DC-EC Repeat Herpes_LMP1 PF05297.11 ETO09452.1 - 0.41 9.8 9.1 0.07 12.3 3.8 1.9 1 1 1 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) LAP1C PF05609.12 ETO09452.1 - 9.4 5.2 27.0 7.2 5.6 25.7 1.4 1 1 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Mito_carr PF00153.27 ETO09453.1 - 1.9e-63 210.4 3.6 4e-24 84.4 0.1 3.5 2 1 1 3 3 3 3 Mitochondrial carrier protein Fuseless PF15993.5 ETO09453.1 - 0.011 14.9 2.1 0.045 12.9 0.1 2.5 3 0 0 3 3 3 0 Fuseless EVC2_like PF12297.8 ETO09453.1 - 0.24 10.0 0.3 0.74 8.4 0.4 1.6 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein RasGEF PF00617.19 ETO09454.1 - 1.1e-21 77.8 0.1 1.5e-21 77.4 0.1 1.1 1 0 0 1 1 1 1 RasGEF domain Zip PF02535.22 ETO09456.1 - 0.43 9.8 4.6 0.49 9.6 4.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sin3a_C PF16879.5 ETO09457.1 - 1.3e-05 25.1 3.2 1.3e-05 25.1 3.2 3.6 1 1 1 2 2 1 1 C-terminal domain of Sin3a protein DUF966 PF06136.13 ETO09457.1 - 0.024 14.4 13.3 0.027 14.2 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CDC45 PF02724.14 ETO09457.1 - 0.034 12.4 19.4 0.042 12.1 19.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.6 ETO09457.1 - 0.17 10.6 15.6 0.24 10.1 15.6 1.1 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 ETO09457.1 - 0.41 9.3 14.1 0.56 8.9 14.1 1.2 1 0 0 1 1 1 0 Presenilin DUF4045 PF13254.6 ETO09457.1 - 1.1 8.8 17.9 1.6 8.3 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Mitofilin PF09731.9 ETO09457.1 - 1.4 7.7 23.0 0.15 10.9 18.8 1.4 2 0 0 2 2 2 0 Mitochondrial inner membrane protein SDA1 PF05285.12 ETO09457.1 - 1.6 8.1 32.5 2.5 7.4 32.5 1.3 1 0 0 1 1 1 0 SDA1 LAP1C PF05609.12 ETO09457.1 - 1.8 7.5 15.3 2.5 7.1 15.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Astro_capsid_p PF12226.8 ETO09457.1 - 3.4 6.7 19.6 5.4 6.1 19.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein IFT57 PF10498.9 ETO09457.1 - 5.3 5.9 25.7 8.2 5.3 25.6 1.6 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 TFIIF_alpha PF05793.12 ETO09457.1 - 8.4 4.9 36.9 3.6 6.1 34.6 1.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Acyl-CoA_dh_1 PF00441.24 ETO09460.1 - 9.8e-24 84.3 0.3 1.4e-23 83.7 0.3 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO09460.1 - 1.1e-06 28.9 0.1 1.5e-06 28.5 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO09460.1 - 0.0021 18.2 0.0 0.7 10.1 0.0 2.5 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, middle domain TnpB_IS66 PF05717.13 ETO09460.1 - 0.13 12.2 0.9 3.3 7.7 0.2 2.4 1 1 1 2 2 2 0 IS66 Orf2 like protein NAPRTase_C PF17956.1 ETO09461.1 - 1.4e-35 122.0 1.1 2.6e-35 121.2 1.1 1.4 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ETO09461.1 - 6e-10 39.1 0.0 0.0008 19.1 0.0 2.2 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 ETO09461.1 - 2.3e-09 37.7 0.3 5e-08 33.4 0.0 2.6 3 0 0 3 3 3 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Flp_N PF03930.14 ETO09461.1 - 0.075 13.0 0.2 1.5 8.8 0.0 2.4 2 0 0 2 2 2 0 Recombinase Flp protein N-terminus RAB3GAP2_N PF14655.6 ETO09462.1 - 0.00042 19.7 0.2 0.00056 19.3 0.2 1.2 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus Membrane_bind PF14564.6 ETO09462.1 - 0.033 14.6 0.4 0.14 12.6 0.0 2.2 3 0 0 3 3 3 0 Membrane binding His_Phos_1 PF00300.22 ETO09463.1 - 9.7e-05 22.1 0.4 0.61 9.7 0.0 3.3 4 0 0 4 4 4 2 Histidine phosphatase superfamily (branch 1) DUF4820 PF16091.5 ETO09463.1 - 1.7 7.9 7.2 2.5 7.4 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) TANGO2 PF05742.12 ETO09464.1 - 2.7e-24 86.6 0.0 3.9e-24 86.1 0.0 1.3 1 0 0 1 1 1 1 Transport and Golgi organisation 2 KilA-N PF04383.13 ETO09464.1 - 0.0034 17.2 0.4 0.0082 16.0 0.4 1.8 1 1 0 1 1 1 1 KilA-N domain Acetyltransf_1 PF00583.25 ETO09465.1 - 3.1e-09 37.1 0.1 2.5e-08 34.2 0.0 2.4 1 1 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO09465.1 - 1.1e-07 32.1 0.0 2e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO09465.1 - 3.2e-07 30.3 0.0 5.4e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETO09465.1 - 0.0017 18.5 0.1 0.047 13.8 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO09465.1 - 0.018 15.0 0.0 0.034 14.1 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_CG PF14542.6 ETO09465.1 - 0.023 14.8 0.0 0.17 12.1 0.0 2.1 2 0 0 2 2 2 0 GCN5-related N-acetyl-transferase SAM_2 PF07647.17 ETO09466.1 - 0.0022 18.0 0.0 0.012 15.7 0.0 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO09466.1 - 0.015 15.7 0.0 0.033 14.6 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) EMC3_TMCO1 PF01956.16 ETO09466.1 - 1.8 8.3 5.1 0.18 11.5 0.7 1.7 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like FKBP_N PF01346.18 ETO09466.1 - 8.3 7.4 8.9 1.9 9.5 4.1 2.1 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Actin PF00022.19 ETO09467.1 - 3.5e-26 91.8 0.3 2.4e-25 89.0 0.3 2.2 1 1 0 1 1 1 1 Actin MCU PF04678.13 ETO09468.1 - 0.15 12.1 8.7 0.36 10.9 1.2 2.8 2 0 0 2 2 2 0 Mitochondrial calcium uniporter BUD22 PF09073.10 ETO09468.1 - 5.3 6.3 32.2 1.7 7.9 14.5 2.2 2 0 0 2 2 2 0 BUD22 ELO PF01151.18 ETO09469.1 - 5.1e-12 45.8 7.4 6.6e-12 45.5 7.4 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family TPR_2 PF07719.17 ETO09471.1 - 0.0061 16.6 0.1 0.015 15.4 0.1 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09471.1 - 0.1 12.4 0.1 0.23 11.3 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO09471.1 - 0.12 12.6 0.0 0.35 11.2 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat EF-hand_1 PF00036.32 ETO09472.1 - 3.2e-08 32.5 1.8 1.8e-05 24.0 0.2 4.1 4 0 0 4 4 4 1 EF hand EF-hand_7 PF13499.6 ETO09472.1 - 2.6e-07 31.0 2.4 1.2e-05 25.7 0.5 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO09472.1 - 8.2e-07 28.5 4.2 9.3e-05 22.1 0.2 4.0 4 0 0 4 4 4 1 EF-hand domain EF-hand_5 PF13202.6 ETO09472.1 - 1.7e-06 27.2 1.8 0.00012 21.4 0.3 3.3 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 ETO09472.1 - 0.0021 17.9 0.7 0.1 12.5 0.2 3.0 3 0 0 3 3 3 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO09472.1 - 0.22 11.8 4.5 0.58 10.5 0.2 2.8 2 2 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region Plasmid_parti PF01672.16 ETO09472.1 - 1.9 9.2 9.5 3.1 8.5 1.6 3.4 2 1 1 3 3 3 0 Putative plasmid partition protein SNARE_assoc PF09335.11 ETO09473.1 - 1.2e-06 29.0 0.3 0.0048 17.4 0.2 2.1 2 0 0 2 2 2 2 SNARE associated Golgi protein DUF2871 PF11070.8 ETO09473.1 - 0.021 15.1 0.7 0.035 14.4 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2871) Plasmodium_Vir PF05795.11 ETO09473.1 - 0.029 13.8 0.1 0.041 13.3 0.1 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Saf_2TM PF18303.1 ETO09473.1 - 0.053 13.1 0.2 0.073 12.7 0.2 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain TMEM210 PF15195.6 ETO09473.1 - 0.12 12.7 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 TMEM210 family Ras PF00071.22 ETO09474.1 - 6.2e-24 84.4 0.0 8.7e-23 80.7 0.0 2.1 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO09474.1 - 0.0015 18.7 0.0 0.05 13.8 0.0 2.7 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 ETO09475.1 - 4.8e-22 77.9 16.1 1.8e-07 31.7 1.9 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09475.1 - 8.2e-08 32.4 0.1 0.0092 16.3 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09475.1 - 2.5e-07 29.7 1.4 0.011 14.4 1.2 2.9 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09475.1 - 0.0081 15.5 0.9 0.022 14.1 0.9 1.7 1 1 0 1 1 1 1 WD40-like domain GST_N_2 PF13409.6 ETO09476.1 - 6.2e-11 42.4 0.1 2.8e-10 40.3 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_3 PF13417.6 ETO09476.1 - 3.1e-10 40.3 0.1 9.7e-10 38.7 0.1 1.9 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETO09476.1 - 2.1e-06 27.6 0.0 5.7e-06 26.3 0.0 1.7 1 1 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO09476.1 - 2.8e-06 27.4 0.2 7.4e-06 26.1 0.1 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C_3 PF14497.6 ETO09476.1 - 2e-05 24.7 0.1 4.6e-05 23.5 0.1 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETO09476.1 - 0.00048 20.4 0.0 0.0011 19.3 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_5 PF16865.5 ETO09476.1 - 0.043 14.4 0.0 0.085 13.4 0.0 1.5 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Phage_Gp15 PF06854.11 ETO09477.1 - 0.0052 16.8 3.8 0.0062 16.5 3.8 1.1 1 0 0 1 1 1 1 Bacteriophage Gp15 protein U1snRNP70_N PF12220.8 ETO09477.1 - 0.03 14.9 4.9 0.04 14.6 4.9 1.2 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF1129 PF06570.11 ETO09477.1 - 0.047 13.2 1.7 0.059 12.9 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) RusA PF05866.11 ETO09477.1 - 0.087 13.4 2.7 0.1 13.1 2.7 1.1 1 0 0 1 1 1 0 Endodeoxyribonuclease RusA PepSY_TM_like_2 PF16357.5 ETO09477.1 - 0.13 12.2 0.8 0.14 12.1 0.8 1.1 1 0 0 1 1 1 0 Putative PepSY_TM-like SET PF00856.28 ETO09477.1 - 0.43 11.0 2.0 0.45 10.9 2.0 1.1 1 0 0 1 1 1 0 SET domain Sugar_tr PF00083.24 ETO09477.1 - 2.1 7.1 5.5 2.4 6.9 5.5 1.1 1 0 0 1 1 1 0 Sugar (and other) transporter DUF4834 PF16118.5 ETO09478.1 - 0.41 11.6 3.6 4.4 8.3 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 ETO09478.1 - 0.6 9.8 5.6 6.5 6.4 0.3 2.7 3 0 0 3 3 3 0 FAM176 family DUF3875 PF12991.7 ETO09479.1 - 0.11 12.5 0.0 0.24 11.4 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3875) Spt5_N PF11942.8 ETO09479.1 - 1.7 9.7 8.7 4.3 8.4 8.7 1.6 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal RhoGEF PF00621.20 ETO09480.1 - 1.3e-07 32.0 0.6 1.3e-07 32.0 0.6 2.1 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 ETO09480.1 - 7.4e-07 29.6 0.2 1.6e-06 28.6 0.2 1.5 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO09480.1 - 0.00031 21.1 1.0 0.0037 17.6 0.1 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain PH_10 PF15411.6 ETO09480.1 - 0.94 9.7 6.1 2.8 8.2 0.3 3.3 2 2 2 4 4 4 0 Pleckstrin homology domain Staph_opine_DH PF10100.9 ETO09481.1 - 0.01 14.5 0.1 0.014 14.0 0.1 1.2 1 0 0 1 1 1 0 Staphylopine dehydrogenase PDEase_I PF00233.19 ETO09481.1 - 0.07 12.8 5.9 0.084 12.6 5.5 1.4 1 1 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Turandot PF07240.11 ETO09481.1 - 1.3 9.0 3.6 10 6.2 0.2 2.3 2 0 0 2 2 2 0 Stress-inducible humoral factor Turandot Amidase PF01425.21 ETO09482.1 - 0.00018 20.6 0.0 0.00034 19.7 0.0 1.4 1 1 0 1 1 1 1 Amidase LMBR1 PF04791.16 ETO09483.1 - 0.0015 17.6 8.6 0.0022 17.0 8.6 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein Jnk-SapK_ap_N PF09744.9 ETO09483.1 - 0.0024 18.1 10.4 0.0024 18.1 10.4 2.1 2 0 0 2 2 2 1 JNK_SAPK-associated protein-1 EAP30 PF04157.16 ETO09483.1 - 0.025 13.9 3.9 0.039 13.3 3.9 1.3 1 0 0 1 1 1 0 EAP30/Vps36 family DUF948 PF06103.11 ETO09483.1 - 0.026 14.7 1.1 0.026 14.7 1.1 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SpoVAD PF07451.11 ETO09483.1 - 0.092 11.4 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) Mod_r PF07200.13 ETO09483.1 - 0.19 11.8 23.9 0.3 11.2 6.5 2.4 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Laminin_II PF06009.12 ETO09483.1 - 0.45 10.5 17.7 0.55 10.2 4.9 2.6 1 1 0 2 2 2 0 Laminin Domain II Noelin-1 PF12308.8 ETO09483.1 - 1.9 8.5 9.0 3.6 7.6 0.1 3.1 1 1 2 3 3 3 0 Neurogenesis glycoprotein DUF4407 PF14362.6 ETO09483.1 - 1.9 7.7 12.2 2.9 7.2 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 ETO09483.1 - 2.3 8.3 25.7 0.38 10.8 9.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 ETO09483.1 - 2.8 8.0 8.2 2.6 8.1 4.0 2.3 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF5339 PF17274.2 ETO09483.1 - 2.8 8.8 11.1 2.8 8.8 1.2 3.3 2 1 1 3 3 3 0 Family of unknown function (DUF5339) DUF1515 PF07439.11 ETO09483.1 - 4 7.5 9.4 0.24 11.4 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) IFT57 PF10498.9 ETO09483.1 - 4.5 6.1 22.8 2.2 7.1 6.2 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 DUF1664 PF07889.12 ETO09483.1 - 4.6 7.3 14.0 0.093 12.8 4.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Fzo_mitofusin PF04799.13 ETO09483.1 - 4.7 6.7 13.4 0.45 10.1 4.8 2.3 2 0 0 2 2 2 0 fzo-like conserved region YtxH PF12732.7 ETO09483.1 - 5.1 7.7 9.7 5.8e+02 1.1 9.7 3.2 1 1 0 1 1 1 0 YtxH-like protein Cupin_4 PF08007.12 ETO09483.1 - 5.5 6.4 9.2 0.72 9.3 3.5 1.9 1 1 1 2 2 2 0 Cupin superfamily protein COG2 PF06148.11 ETO09483.1 - 5.8 7.0 18.3 0.078 13.1 3.1 2.5 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 GBP_C PF02841.14 ETO09483.1 - 9.8 5.5 27.5 1.5 8.1 7.2 2.1 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain DUF4404 PF14357.6 ETO09483.1 - 9.9 6.9 19.2 4.8 7.9 6.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) DUF4200 PF13863.6 ETO09484.1 - 9.6e-33 113.1 24.5 9.6e-33 113.1 24.5 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4200) FAM76 PF16046.5 ETO09484.1 - 1.2 8.4 22.5 1.8 7.9 22.5 1.2 1 0 0 1 1 1 0 FAM76 protein SLATT_5 PF18160.1 ETO09484.1 - 1.7 7.9 9.9 0.3 10.4 6.0 1.7 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 Adap_comp_sub PF00928.21 ETO09485.1 - 1.4e-40 139.4 0.2 1.8e-40 139.0 0.2 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETO09485.1 - 0.0094 15.9 0.1 0.025 14.5 0.0 1.8 2 0 0 2 2 2 1 Clathrin adaptor complex small chain CSD PF00313.22 ETO09486.1 - 5.2e-05 23.0 8.2 0.04 13.8 0.1 3.8 4 0 0 4 4 4 3 'Cold-shock' DNA-binding domain DUF5357 PF17310.2 ETO09486.1 - 0.071 11.7 0.2 0.14 10.7 0.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5357) LRRNT_2 PF08263.12 ETO09487.1 - 3.8 7.9 6.8 0.76 10.1 1.9 2.4 2 1 0 2 2 2 0 Leucine rich repeat N-terminal domain STAS PF01740.21 ETO09489.1 - 4e-19 68.4 0.0 7.2e-19 67.5 0.0 1.4 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO09489.1 - 0.0056 15.5 1.8 0.0085 14.9 1.8 1.3 1 0 0 1 1 1 1 Sulfate permease family Mo-co_dimer PF03404.16 ETO09490.1 - 0.091 12.8 0.1 0.22 11.6 0.0 1.5 1 1 1 2 2 2 0 Mo-co oxidoreductase dimerisation domain G-alpha PF00503.20 ETO09491.1 - 1.7e-67 228.1 14.7 2.4e-67 227.6 14.7 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO09491.1 - 6.3e-09 35.5 0.5 6.3e-09 35.5 0.5 2.0 2 1 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 ETO09491.1 - 0.011 15.9 2.0 0.016 15.5 0.2 2.3 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF2408 PF10303.9 ETO09491.1 - 0.1 13.2 1.5 0.2 12.2 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) DUF4349 PF14257.6 ETO09492.1 - 0.17 11.3 0.2 0.2 11.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) CPSase_L_D2 PF02786.17 ETO09494.1 - 1.7e-39 135.5 0.0 2.2e-39 135.1 0.0 1.1 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 ETO09494.1 - 1.5e-11 44.3 0.0 2.9e-11 43.4 0.0 1.4 1 0 0 1 1 1 1 Biotin carboxylase C-terminal domain RimK PF08443.11 ETO09494.1 - 0.014 15.0 0.0 0.02 14.5 0.0 1.2 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Biotin_carb_C PF02785.19 ETO09495.1 - 3.7e-19 68.8 0.1 4.2e-17 62.2 0.0 2.6 2 1 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_lipoyl PF00364.22 ETO09495.1 - 1.5e-17 63.2 1.1 1.5e-17 63.2 1.1 1.9 2 0 0 2 2 2 1 Biotin-requiring enzyme PCC_BT PF18140.1 ETO09495.1 - 4.9e-13 49.5 0.0 8.4e-13 48.8 0.0 1.3 1 0 0 1 1 1 1 Propionyl-coenzyme A carboxylase BT domain Biotin_lipoyl_2 PF13533.6 ETO09495.1 - 7.3e-08 32.1 0.5 0.0013 18.5 0.2 2.6 1 1 1 2 2 2 2 Biotin-lipoyl like HlyD_3 PF13437.6 ETO09495.1 - 8.5e-06 26.4 0.2 0.024 15.3 0.0 2.8 3 0 0 3 3 3 2 HlyD family secretion protein HlyD_D23 PF16576.5 ETO09495.1 - 1.2e-05 24.7 0.2 0.091 12.0 0.0 2.3 1 1 1 2 2 2 2 Barrel-sandwich domain of CusB or HlyD membrane-fusion YqfD PF06898.11 ETO09495.1 - 0.01 14.7 3.4 0.15 10.8 1.3 2.7 2 1 1 3 3 3 0 Putative stage IV sporulation protein YqfD PTS_EIIA_1 PF00358.20 ETO09495.1 - 0.014 15.2 2.2 0.66 9.7 0.1 2.8 2 1 1 3 3 3 0 phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1 GCV_H PF01597.19 ETO09495.1 - 0.022 14.6 0.1 0.039 13.8 0.1 1.4 1 0 0 1 1 1 0 Glycine cleavage H-protein RnfC_N PF13375.6 ETO09495.1 - 0.057 13.4 1.4 1.9 8.5 0.2 2.7 2 1 1 3 3 3 0 RnfC Barrel sandwich hybrid domain QRPTase_N PF02749.16 ETO09495.1 - 0.22 11.6 0.8 6.4 6.9 0.0 2.7 2 1 1 3 3 3 0 Quinolinate phosphoribosyl transferase, N-terminal domain Peptidase_M23 PF01551.22 ETO09495.1 - 0.41 10.9 1.8 15 5.8 0.1 2.6 1 1 1 2 2 2 0 Peptidase family M23 Glyco_transf_34 PF05637.12 ETO09496.1 - 1.4e-11 44.6 7.0 2.4e-10 40.5 6.9 2.5 1 1 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family MFS_1 PF07690.16 ETO09497.1 - 0.0056 15.6 15.2 0.0069 15.3 15.2 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily LRR_9 PF14580.6 ETO09498.1 - 2.6e-14 53.1 3.3 4.9e-14 52.2 3.3 1.4 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ETO09498.1 - 7.2e-08 32.6 23.3 0.00025 21.4 3.2 3.7 4 1 2 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO09498.1 - 1.6e-05 24.6 10.7 0.00013 21.7 0.2 3.6 2 1 1 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 ETO09498.1 - 9.4 7.2 6.3 80 4.4 2.0 4.1 4 1 0 4 4 4 0 Leucine Rich Repeat zf-CCCH PF00642.24 ETO09499.1 - 3.6e-09 36.3 15.8 6.6e-06 25.9 2.1 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) RRM_1 PF00076.22 ETO09499.1 - 1.9e-06 27.6 0.0 4e-06 26.5 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Torus PF16131.5 ETO09499.1 - 0.0057 17.3 6.4 0.16 12.7 0.3 2.7 3 0 0 3 3 3 2 Torus domain zf_CCCH_4 PF18345.1 ETO09499.1 - 0.05 13.7 2.6 0.05 13.7 2.6 3.4 3 0 0 3 3 3 0 Zinc finger domain Peptidase_M19 PF01244.21 ETO09500.1 - 0.088 12.0 0.1 0.13 11.4 0.1 1.1 1 0 0 1 1 1 0 Membrane dipeptidase (Peptidase family M19) RVT_N PF13655.6 ETO09501.1 - 0.44 10.9 4.1 3.6 7.9 0.1 3.7 5 0 0 5 5 5 0 N-terminal domain of reverse transcriptase ECH_1 PF00378.20 ETO09502.1 - 5.8e-20 71.7 0.0 7.4e-20 71.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO09502.1 - 1.7e-06 27.8 0.0 3.1e-05 23.6 0.0 1.9 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase PHM7_ext PF12621.8 ETO09505.1 - 0.032 14.4 0.5 0.14 12.3 0.1 2.3 2 0 0 2 2 2 0 Extracellular tail, of 10TM putative phosphate transporter Ion_trans PF00520.31 ETO09505.1 - 0.062 12.5 0.1 0.062 12.5 0.1 2.1 2 0 0 2 2 2 0 Ion transport protein PUF PF00806.19 ETO09506.1 - 1.5e-18 65.4 0.7 1.1e-06 28.0 0.1 3.4 3 0 0 3 3 3 3 Pumilio-family RNA binding repeat Phenyl_P_gamma PF09662.10 ETO09506.1 - 0.0069 16.5 0.2 4.5 7.5 0.0 3.2 2 1 1 3 3 3 1 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) CBF PF03914.17 ETO09506.1 - 0.066 13.3 0.1 0.083 12.9 0.1 1.3 1 1 0 1 1 1 0 CBF/Mak21 family Glyco_hydro_9 PF00759.19 ETO09506.1 - 0.22 10.9 0.0 0.25 10.7 0.0 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 9 TPR_1 PF00515.28 ETO09507.1 - 0.0046 16.7 2.5 0.34 10.8 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09507.1 - 0.036 14.2 3.9 17 5.8 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat PDDEXK_9 PF08011.11 ETO09507.1 - 0.056 13.3 1.8 0.48 10.4 0.0 2.6 2 0 0 2 2 2 0 PD-(D/E)XK nuclease superfamily PDR_CDR PF06422.12 ETO09507.1 - 0.57 10.1 6.8 0.61 10.0 4.5 2.3 2 1 0 2 2 2 0 CDR ABC transporter Rtf2 PF04641.12 ETO09507.1 - 0.78 9.0 16.0 0.25 10.6 12.6 1.9 1 1 1 2 2 2 0 Rtf2 RING-finger YajC PF02699.15 ETO09507.1 - 7.6 6.5 7.9 0.35 10.8 1.2 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit TRAF6_Z2 PF18048.1 ETO09508.1 - 0.0061 16.6 4.7 0.013 15.6 4.7 1.4 1 0 0 1 1 1 1 TNF receptor-associated factor 6 zinc finger 2 CCDC106 PF15794.5 ETO09508.1 - 0.0065 16.2 11.4 0.013 15.3 0.7 2.1 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 106 Zn-ribbon_8 PF09723.10 ETO09508.1 - 0.026 14.6 5.5 0.077 13.1 5.4 1.9 1 1 0 1 1 1 0 Zinc ribbon domain T3SS_needle_reg PF09025.10 ETO09508.1 - 0.047 13.7 0.4 0.09 12.8 0.4 1.5 1 0 0 1 1 1 0 YopR, type III needle-polymerisation regulator DUF3752 PF12572.8 ETO09508.1 - 2.5 8.6 18.6 1 9.9 3.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3752) EMC3_TMCO1 PF01956.16 ETO09508.1 - 3.9 7.2 10.9 3.1 7.5 4.3 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like BSP_II PF05432.11 ETO09509.1 - 1.6 8.3 10.9 0.11 12.1 5.9 1.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Kinesin PF00225.23 ETO09510.1 - 6e-24 84.6 2.0 1.2e-17 63.8 0.6 2.1 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ETO09510.1 - 6.2e-13 48.9 0.0 1.3e-12 47.9 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding DUF2443 PF10398.9 ETO09510.1 - 0.0066 16.5 0.1 0.014 15.4 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2443) zf-RING_5 PF14634.6 ETO09511.1 - 0.00065 19.6 3.9 0.00065 19.6 3.9 3.3 2 1 0 2 2 2 1 zinc-RING finger domain zf-TRAF PF02176.18 ETO09511.1 - 0.019 15.7 9.8 0.019 15.7 9.8 4.0 2 2 1 3 3 3 0 TRAF-type zinc finger WD40 PF00400.32 ETO09512.1 - 1.6e-07 31.8 3.6 2.1e-05 25.2 0.1 3.6 3 0 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO09512.1 - 0.091 11.4 0.1 0.18 10.4 0.1 1.6 2 0 0 2 2 2 0 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO09512.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ETO09513.1 - 3.1e-05 24.6 3.7 7.2e-05 23.5 0.7 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat LTD PF00932.19 ETO09514.1 - 0.00014 22.2 0.0 0.0003 21.1 0.0 1.5 1 0 0 1 1 1 1 Lamin Tail Domain Filament PF00038.21 ETO09514.1 - 0.0013 18.4 0.4 0.0013 18.4 0.4 1.9 2 0 0 2 2 2 1 Intermediate filament protein TPR_14 PF13428.6 ETO09515.1 - 0.0026 18.4 0.2 0.043 14.6 0.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09515.1 - 0.0039 17.2 2.3 0.64 10.3 0.2 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09515.1 - 0.058 13.2 1.7 4 7.4 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO09515.1 - 0.11 12.8 0.1 3.2 8.1 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Mem_trans PF03547.18 ETO09515.1 - 6.5 5.0 5.6 0.65 8.3 0.3 2.0 2 0 0 2 2 2 0 Membrane transport protein Mito_carr PF00153.27 ETO09516.1 - 5.8e-21 74.2 1.7 6.3e-13 48.5 0.1 2.8 1 1 2 3 3 3 2 Mitochondrial carrier protein Heliorhodopsin PF18761.1 ETO09516.1 - 0.078 12.3 0.0 0.14 11.5 0.0 1.4 1 0 0 1 1 1 0 Heliorhodopsin zf-H2C2_2 PF13465.6 ETO09517.1 - 7.9e-12 45.0 22.2 4.8e-08 33.1 2.0 3.6 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 ETO09517.1 - 1.7e-09 37.6 22.2 0.0022 18.4 4.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO09517.1 - 9.6e-06 26.0 16.5 0.082 13.8 0.9 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETO09517.1 - 5.1e-05 23.1 18.7 0.00038 20.4 1.6 3.4 3 0 0 3 3 3 3 C2H2-type zinc finger zf-BED PF02892.15 ETO09517.1 - 7.5e-05 22.7 17.9 0.017 15.1 1.9 4.0 1 1 2 3 3 3 2 BED zinc finger TMCO5 PF14992.6 ETO09517.1 - 0.024 14.2 0.2 0.024 14.2 0.2 2.1 1 1 1 2 2 1 0 TMCO5 family PyrI_C PF02748.15 ETO09517.1 - 0.39 10.7 20.0 0.21 11.5 1.0 3.9 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_jaz PF12171.8 ETO09517.1 - 0.43 10.9 18.1 2.1 8.7 1.5 3.9 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-CHCC PF10276.9 ETO09517.1 - 0.65 10.1 7.8 4.9 7.3 0.2 3.4 3 0 0 3 3 3 0 Zinc-finger domain PHD_4 PF16866.5 ETO09517.1 - 0.66 10.1 3.9 2.2 8.4 3.9 2.0 1 1 0 1 1 1 0 PHD-finger zf-C2HE PF16278.5 ETO09517.1 - 2.4 8.7 13.2 16 6.0 6.5 3.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Zn-ribbon_8 PF09723.10 ETO09517.1 - 4.7 7.4 6.1 33 4.7 0.2 2.5 2 0 0 2 2 2 0 Zinc ribbon domain AAA PF00004.29 ETO09518.1 - 2.8e-43 147.5 0.1 6.5e-43 146.3 0.0 1.7 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO09518.1 - 1.7e-10 40.5 0.2 3.2e-10 39.6 0.2 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ETO09518.1 - 1.4e-07 31.8 0.1 4.2e-07 30.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO09518.1 - 1.2e-05 25.6 0.1 0.0023 18.2 0.1 2.4 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO09518.1 - 2e-05 24.6 0.2 8.9e-05 22.5 0.2 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ETO09518.1 - 2.6e-05 23.5 0.0 5.7e-05 22.4 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 ETO09518.1 - 4.3e-05 23.3 0.0 0.00011 22.0 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETO09518.1 - 9.7e-05 22.8 0.1 0.0012 19.3 0.1 2.2 1 1 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ETO09518.1 - 0.00092 19.8 0.1 0.011 16.2 0.0 2.2 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ETO09518.1 - 0.00093 19.0 0.1 0.0026 17.5 0.0 1.7 2 0 0 2 2 1 1 IstB-like ATP binding protein AAA_33 PF13671.6 ETO09518.1 - 0.003 17.7 0.0 0.0057 16.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ETO09518.1 - 0.0034 17.4 0.1 0.011 15.7 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_28 PF13521.6 ETO09518.1 - 0.0065 16.7 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO09518.1 - 0.0072 16.7 0.0 0.018 15.4 0.0 1.7 1 0 0 1 1 1 1 RNA helicase Mg_chelatase PF01078.21 ETO09518.1 - 0.011 15.2 0.0 0.02 14.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI PhoH PF02562.16 ETO09518.1 - 0.012 15.1 0.2 0.091 12.2 0.1 2.1 2 0 0 2 2 2 0 PhoH-like protein ATPase PF06745.13 ETO09518.1 - 0.013 14.9 0.1 0.34 10.2 0.0 2.3 1 1 1 2 2 2 0 KaiC AAA_25 PF13481.6 ETO09518.1 - 0.018 14.6 0.5 0.22 11.1 0.2 2.3 1 1 1 2 2 2 0 AAA domain TIP49 PF06068.13 ETO09518.1 - 0.018 14.3 0.0 0.037 13.2 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Prot_ATP_OB_N PF17758.1 ETO09518.1 - 0.03 14.0 0.1 0.22 11.2 0.0 2.5 3 0 0 3 3 3 0 Proteasomal ATPase OB N-terminal domain AAA_30 PF13604.6 ETO09518.1 - 0.031 14.0 0.2 0.074 12.8 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ETO09518.1 - 0.036 13.9 0.0 0.12 12.2 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETO09518.1 - 0.04 13.8 0.0 0.24 11.3 0.0 2.2 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ETO09518.1 - 0.041 13.6 1.6 0.055 13.2 0.2 2.0 2 1 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETO09518.1 - 0.076 12.5 0.0 0.22 11.0 0.0 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 ETO09518.1 - 0.11 11.6 0.0 0.2 10.7 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 TsaE PF02367.17 ETO09518.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE LRR_6 PF13516.6 ETO09519.1 - 1.2e-11 43.6 18.4 0.03 14.4 0.0 7.3 7 0 0 7 7 7 5 Leucine Rich repeat NifU_N PF01592.16 ETO09519.1 - 0.00081 19.5 0.0 0.0018 18.4 0.0 1.5 1 0 0 1 1 1 1 NifU-like N terminal domain ABC1 PF03109.16 ETO09521.1 - 2.1e-10 40.8 0.0 4.1e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 ABC1 family AHJR-like PF18743.1 ETO09521.1 - 0.1 12.2 0.2 0.41 10.2 0.0 1.9 2 0 0 2 2 2 0 REase_AHJR-like BORA_N PF15280.6 ETO09521.1 - 0.13 11.9 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Protein aurora borealis N-terminus Pkinase PF00069.25 ETO09522.1 - 0.043 13.2 0.0 0.065 12.6 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain CDC13_N PF16853.5 ETO09523.1 - 0.0012 18.4 1.0 0.0012 18.4 1.0 1.7 1 1 1 2 2 2 1 Cell division control protein 13 N-terminus PrgI PF12666.7 ETO09524.1 - 0.0017 19.0 0.3 0.017 15.8 0.0 2.2 2 0 0 2 2 2 1 PrgI family protein Tetraspanin PF00335.20 ETO09524.1 - 0.63 9.7 5.8 0.22 11.2 1.0 2.1 2 0 0 2 2 2 0 Tetraspanin family Ras PF00071.22 ETO09525.1 - 1.1e-09 38.0 0.4 1.1e-09 38.0 0.4 1.8 3 0 0 3 3 3 1 Ras family Arf PF00025.21 ETO09525.1 - 0.0064 16.0 0.2 0.011 15.2 0.2 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO09525.1 - 0.016 15.1 0.2 0.041 13.8 0.1 1.6 1 1 1 2 2 2 0 RsgA GTPase LIFR_D2 PF17971.1 ETO09525.1 - 0.051 13.8 0.2 0.22 11.7 0.1 2.0 2 1 0 2 2 2 0 Leukemia inhibitory factor receptor D2 domain GTP_EFTU PF00009.27 ETO09525.1 - 0.12 11.8 0.3 0.27 10.7 0.3 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RhoGEF PF00621.20 ETO09526.1 - 9.6e-15 55.3 13.4 4.6e-14 53.1 13.4 2.1 1 1 0 1 1 1 1 RhoGEF domain PH PF00169.29 ETO09528.1 - 0.00041 20.8 12.0 0.0064 17.0 1.7 4.4 3 1 0 3 3 3 2 PH domain Atrophin-1 PF03154.15 ETO09528.1 - 0.00093 17.6 7.4 0.00093 17.6 7.4 2.6 3 0 0 3 3 3 1 Atrophin-1 family PH_11 PF15413.6 ETO09528.1 - 0.011 16.2 2.3 0.011 16.2 2.3 5.0 5 1 0 5 5 5 0 Pleckstrin homology domain DUF3915 PF13054.6 ETO09528.1 - 6.1 6.8 13.2 0.024 14.6 1.5 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) Hist_deacetyl PF00850.19 ETO09529.1 - 2.6e-23 83.0 0.0 3.7e-23 82.5 0.0 1.1 1 0 0 1 1 1 1 Histone deacetylase domain DUF4084 PF13321.6 ETO09529.1 - 0.013 15.1 5.1 0.02 14.5 5.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4084) CxC1 PF18802.1 ETO09529.1 - 0.42 10.8 3.2 0.33 11.1 0.2 2.3 3 0 0 3 3 3 0 CxC1 like cysteine cluster associated with KDZ transposases PrgH PF09480.10 ETO09530.1 - 0.025 13.9 6.2 0.034 13.5 5.0 1.8 1 1 1 2 2 2 0 Type III secretion system protein PrgH-EprH (PrgH) DUF2951 PF11166.8 ETO09530.1 - 0.36 11.1 8.0 1 9.6 7.6 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF2951) TFIIA PF03153.13 ETO09530.1 - 0.48 10.4 16.7 0.26 11.3 1.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Adap_comp_sub PF00928.21 ETO09531.1 - 5.1e-27 94.9 0.1 5.9e-26 91.4 0.1 2.1 1 1 0 1 1 1 1 Adaptor complexes medium subunit family Longin PF13774.6 ETO09531.1 - 0.096 12.7 0.1 0.25 11.4 0.1 1.7 1 0 0 1 1 1 0 Regulated-SNARE-like domain Proteasom_PSMB PF10508.9 ETO09532.1 - 3.4e-16 58.8 0.2 4.3e-16 58.5 0.2 1.1 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit DUF4704 PF15787.5 ETO09532.1 - 2.4 7.3 9.4 1.4 8.1 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4704) Sec7_N PF12783.7 ETO09533.1 - 5.3e-08 32.9 0.1 1.2e-07 31.7 0.1 1.6 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Actin PF00022.19 ETO09534.1 - 2.6e-113 378.7 0.0 8.8e-113 377.0 0.0 1.7 1 1 0 1 1 1 1 Actin SPX PF03105.19 ETO09535.1 - 0.00016 21.7 15.6 0.00039 20.5 10.5 2.1 1 1 1 2 2 2 1 SPX domain OST3_OST6 PF04756.13 ETO09535.1 - 0.0095 15.3 0.1 0.012 15.0 0.1 1.2 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family ECH_2 PF16113.5 ETO09535.1 - 0.048 13.1 1.0 0.058 12.9 1.0 1.1 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase GIDA PF01134.22 ETO09535.1 - 0.072 12.2 4.3 0.088 11.9 4.3 1.1 1 0 0 1 1 1 0 Glucose inhibited division protein A Ribosomal_S20p PF01649.18 ETO09535.1 - 0.68 10.6 8.6 3.7 8.3 2.7 2.2 1 1 1 2 2 2 0 Ribosomal protein S20 DUF3808 PF10300.9 ETO09535.1 - 5.6 5.6 11.0 0.73 8.5 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3808) GPI2 PF06432.11 ETO09537.1 - 4.8e-32 111.5 18.6 5.4e-32 111.3 18.6 1.0 1 0 0 1 1 1 1 Phosphatidylinositol N-acetylglucosaminyltransferase Kelch_6 PF13964.6 ETO09539.1 - 1.7e-05 24.9 15.8 0.00029 21.0 1.5 4.4 4 1 1 5 5 5 2 Kelch motif PT PF04886.12 ETO09539.1 - 7e-05 22.3 58.3 0.052 13.1 14.7 4.6 1 1 2 3 3 2 2 PT repeat ABC2_membrane_3 PF12698.7 ETO09539.1 - 0.00032 19.9 0.2 0.00032 19.9 0.2 3.8 4 1 1 5 5 5 1 ABC-2 family transporter protein Kelch_5 PF13854.6 ETO09539.1 - 0.0016 18.4 3.0 0.0071 16.3 3.0 2.1 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 ETO09539.1 - 0.0058 16.6 2.1 0.056 13.4 0.3 2.7 2 0 0 2 2 2 1 Kelch motif CrgA PF06781.12 ETO09539.1 - 0.019 15.0 0.0 0.14 12.2 0.0 2.5 1 0 0 1 1 1 0 Cell division protein CrgA TMEM154 PF15102.6 ETO09539.1 - 0.043 13.7 0.1 0.043 13.7 0.1 2.7 4 0 0 4 4 2 0 TMEM154 protein family Insulin_TMD PF17870.1 ETO09539.1 - 0.12 12.4 0.8 0.39 10.8 0.8 1.8 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment Kelch_1 PF01344.25 ETO09539.1 - 0.2 11.3 11.0 0.062 12.9 1.0 3.2 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO09539.1 - 0.25 11.4 3.5 0.15 12.1 0.2 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Orf78 PF06024.12 ETO09539.1 - 0.3 11.4 0.0 0.3 11.4 0.0 3.8 5 0 0 5 5 5 0 Orf78 (ac78) Keratin_2_head PF16208.5 ETO09539.1 - 1.7 8.8 26.7 0.21 11.7 21.5 2.1 2 1 0 2 2 2 0 Keratin type II head BUD22 PF09073.10 ETO09540.1 - 0.11 11.8 27.2 0.17 11.2 27.2 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO09540.1 - 0.71 8.0 28.4 1 7.5 28.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO09540.1 - 1 7.6 24.8 1.4 7.1 24.3 1.4 2 0 0 2 2 2 0 CDC45-like protein SURF2 PF05477.11 ETO09540.1 - 1.5 8.4 21.2 2.6 7.7 21.2 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SDA1 PF05285.12 ETO09540.1 - 2.3 7.6 31.8 3.8 6.8 31.8 1.3 1 0 0 1 1 1 0 SDA1 SpoIIIAH PF12685.7 ETO09540.1 - 5.4 6.8 18.7 9.5 6.0 18.7 1.3 1 0 0 1 1 1 0 SpoIIIAH-like protein Nop16 PF09420.10 ETO09541.1 - 0.015 15.4 0.1 0.027 14.5 0.1 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein Nop16 ACPS PF01648.20 ETO09541.1 - 0.11 12.7 0.1 0.21 11.8 0.1 1.5 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase superfamily SPRY PF00622.28 ETO09543.1 - 6.3e-12 45.7 0.1 2e-11 44.1 0.1 1.8 1 0 0 1 1 1 1 SPRY domain Atrophin-1 PF03154.15 ETO09543.1 - 0.0022 16.4 8.2 0.0028 16.0 8.2 1.0 1 0 0 1 1 1 1 Atrophin-1 family Rtf2 PF04641.12 ETO09544.1 - 7.1e-42 143.6 18.3 8.4e-40 136.8 18.3 2.1 1 1 0 1 1 1 1 Rtf2 RING-finger TFB6 PF17110.5 ETO09544.1 - 0.062 13.0 1.4 0.13 12.0 1.4 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH MRP-S26 PF14943.6 ETO09544.1 - 0.085 12.8 22.0 0.14 12.0 17.5 2.1 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 ANAPC15 PF15243.6 ETO09544.1 - 0.13 12.7 12.5 0.33 11.4 12.5 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 TraV PF09676.10 ETO09544.1 - 0.13 13.3 7.0 0.21 12.5 7.0 1.3 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) PBP1_TM PF14812.6 ETO09544.1 - 1.9 8.9 11.5 4.3 7.8 11.5 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNA_pol_Rpc4 PF05132.14 ETO09544.1 - 3.4 8.1 9.8 5.7 7.4 9.8 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 FAM176 PF14851.6 ETO09544.1 - 5 6.8 8.0 8 6.1 8.0 1.4 1 0 0 1 1 1 0 FAM176 family Zip PF02535.22 ETO09544.1 - 6 6.0 9.7 10 5.2 9.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO09544.1 - 6.5 4.9 17.5 9.2 4.4 17.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO09544.1 - 8.1 6.7 23.5 0.9 9.8 19.1 1.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Phage_Mu_Gam PF07352.12 ETO09545.1 - 0.0016 18.4 7.6 0.002 18.1 7.6 1.2 1 0 0 1 1 1 1 Bacteriophage Mu Gam like protein DUF1993 PF09351.10 ETO09545.1 - 0.0042 17.3 0.4 0.005 17.0 0.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) CALCOCO1 PF07888.11 ETO09545.1 - 0.022 13.6 11.0 0.022 13.6 11.0 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Muted PF14942.6 ETO09545.1 - 0.027 14.8 9.6 0.032 14.6 9.6 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Phage_GPO PF05929.11 ETO09545.1 - 0.027 14.1 5.7 0.03 14.0 5.7 1.0 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Spc7 PF08317.11 ETO09545.1 - 0.17 10.7 12.0 0.19 10.6 12.0 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein TMPIT PF07851.13 ETO09545.1 - 0.2 10.9 7.2 0.2 10.9 7.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4078 PF13300.6 ETO09545.1 - 0.24 11.8 14.1 1.5 9.2 5.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4078) FAD-SLDH PF12318.8 ETO09545.1 - 0.36 10.9 4.0 3 7.9 1.4 2.0 1 1 1 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase DASH_Hsk3 PF08227.11 ETO09545.1 - 0.5 10.8 4.4 0.85 10.0 2.0 2.3 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like DUF16 PF01519.16 ETO09545.1 - 1.7 9.1 11.4 2.9 8.4 11.3 1.4 1 1 0 1 1 1 0 Protein of unknown function DUF16 Sec62 PF03839.16 ETO09545.1 - 2.1 7.8 8.9 2.3 7.7 8.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Csm1_N PF18504.1 ETO09545.1 - 3.5 8.0 15.9 16 6.0 12.5 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain LMBR1 PF04791.16 ETO09545.1 - 5.3 5.8 5.4 5.4 5.8 5.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein EMC3_TMCO1 PF01956.16 ETO09545.1 - 8.2 6.1 8.9 8.7 6.0 8.3 1.3 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Pkinase PF00069.25 ETO09546.1 - 4.4e-13 49.2 0.0 6.8e-13 48.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09546.1 - 0.0011 18.3 0.0 0.0016 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase SOG2 PF10428.9 ETO09546.1 - 0.52 9.5 11.4 0.71 9.0 11.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Macoilin PF09726.9 ETO09546.1 - 1.4 7.4 7.2 1.8 7.0 7.2 1.1 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 ETO09546.1 - 4.5 6.0 6.7 7.3 5.3 6.7 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA PF00004.29 ETO09547.1 - 1.9e-43 148.1 0.0 2.7e-43 147.5 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO09547.1 - 1.9e-06 28.4 0.0 0.0047 17.3 0.0 2.2 1 1 0 2 2 2 2 AAA ATPase domain AAA_33 PF13671.6 ETO09547.1 - 2.5e-06 27.7 0.0 3.9e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_2 PF07724.14 ETO09547.1 - 4.1e-06 27.0 0.0 5.7e-06 26.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ETO09547.1 - 6.6e-06 26.2 0.0 4e-05 23.6 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO09547.1 - 4.6e-05 23.7 0.1 0.013 15.7 0.0 2.2 1 1 1 2 2 2 1 AAA domain RuvB_N PF05496.12 ETO09547.1 - 6e-05 22.8 0.0 0.00027 20.7 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain NACHT PF05729.12 ETO09547.1 - 0.0015 18.5 0.0 0.044 13.7 0.0 2.1 2 0 0 2 2 2 1 NACHT domain AAA_14 PF13173.6 ETO09547.1 - 0.0016 18.5 0.0 0.0026 17.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ETO09547.1 - 0.0025 17.4 0.0 0.052 13.1 0.0 2.1 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETO09547.1 - 0.0031 16.9 0.1 0.0069 15.8 0.1 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ETO09547.1 - 0.005 17.2 0.0 0.0087 16.4 0.0 1.5 1 1 0 1 1 1 1 RNA helicase Rad17 PF03215.15 ETO09547.1 - 0.0065 16.4 0.0 0.0081 16.1 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_18 PF13238.6 ETO09547.1 - 0.0078 16.8 0.0 0.012 16.1 0.0 1.5 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 ETO09547.1 - 0.011 15.7 0.0 0.023 14.7 0.0 1.5 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ETO09547.1 - 0.013 15.1 0.0 0.028 14.0 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region IstB_IS21 PF01695.17 ETO09547.1 - 0.021 14.6 0.0 0.059 13.1 0.0 1.7 2 0 0 2 2 2 0 IstB-like ATP binding protein Viral_helicase1 PF01443.18 ETO09547.1 - 0.04 13.6 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 ETO09547.1 - 0.076 12.2 0.0 0.14 11.3 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 ETO09547.1 - 0.079 12.7 0.0 0.57 9.9 0.0 2.1 1 1 0 1 1 1 0 Sigma-54 interaction domain TniB PF05621.11 ETO09547.1 - 0.086 12.2 0.0 0.24 10.8 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein TIP49 PF06068.13 ETO09547.1 - 0.09 12.0 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 ETO09547.1 - 0.12 12.6 0.0 0.15 12.3 0.0 1.5 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ETO09547.1 - 0.12 11.5 0.0 0.15 11.2 0.0 1.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) ATPase_2 PF01637.18 ETO09547.1 - 0.13 12.2 0.0 18 5.2 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_11 PF13086.6 ETO09547.1 - 0.19 11.5 0.0 0.28 10.9 0.0 1.2 1 0 0 1 1 1 0 AAA domain U-box PF04564.15 ETO09548.1 - 8e-17 61.2 0.0 1.5e-16 60.3 0.0 1.5 1 0 0 1 1 1 1 U-box domain SAM_1 PF00536.30 ETO09548.1 - 6.4e-08 32.9 0.8 1.2e-07 32.0 0.4 1.7 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO09548.1 - 7.9e-06 25.9 0.8 2.1e-05 24.5 0.3 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Rtf2 PF04641.12 ETO09548.1 - 2.5e-05 23.8 1.6 3.5e-05 23.3 1.6 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger Glyoxalase PF00903.25 ETO09548.1 - 0.027 14.6 0.1 0.034 14.3 0.1 1.2 1 0 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF3510 PF12022.8 ETO09548.1 - 0.028 14.8 3.1 0.046 14.1 3.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) CSRNP_N PF16019.5 ETO09548.1 - 0.054 13.4 7.2 0.071 13.0 7.2 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Vfa1 PF08432.10 ETO09548.1 - 0.068 13.5 12.8 0.087 13.2 12.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NPR3 PF03666.13 ETO09548.1 - 0.072 11.9 6.0 0.086 11.6 6.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2457 PF10446.9 ETO09548.1 - 0.11 11.7 16.4 0.13 11.3 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-Nse PF11789.8 ETO09548.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RRN3 PF05327.11 ETO09548.1 - 0.21 10.1 10.3 0.25 9.8 10.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zip PF02535.22 ETO09548.1 - 0.31 10.2 2.0 0.35 10.1 2.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SGT1 PF07093.11 ETO09548.1 - 0.54 8.6 11.8 0.66 8.3 11.8 1.1 1 0 0 1 1 1 0 SGT1 protein NOA36 PF06524.12 ETO09548.1 - 0.6 9.4 14.3 0.76 9.0 14.3 1.1 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO09548.1 - 0.63 8.7 4.9 0.7 8.6 4.9 1.2 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 ETO09548.1 - 0.8 9.7 8.1 0.99 9.4 8.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RP-C_C PF11800.8 ETO09548.1 - 1.2 9.2 4.5 1.5 8.8 4.5 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region RPN2_C PF18004.1 ETO09548.1 - 1.2 9.0 10.7 2 8.3 10.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2076 PF09849.9 ETO09548.1 - 2.5 8.1 11.1 3.4 7.6 11.1 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CDC45 PF02724.14 ETO09548.1 - 3.1 6.0 12.6 3.7 5.7 12.6 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 ETO09548.1 - 3.5 6.4 5.1 3.9 6.2 5.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FancD2 PF14631.6 ETO09548.1 - 3.6 4.8 9.3 4.6 4.5 9.3 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease uDENN PF03456.18 ETO09549.1 - 1.6e-05 25.5 0.0 5.9e-05 23.7 0.0 2.0 2 0 0 2 2 2 1 uDENN domain DENN PF02141.21 ETO09549.1 - 0.026 14.5 0.1 0.056 13.4 0.1 1.5 1 0 0 1 1 1 0 DENN (AEX-3) domain CBF PF03914.17 ETO09549.1 - 0.59 10.2 3.3 1.6 8.7 0.6 2.3 2 1 0 2 2 2 0 CBF/Mak21 family MecA PF05389.12 ETO09549.1 - 0.78 9.3 7.2 1.5 8.4 7.2 1.6 1 1 0 1 1 1 0 Negative regulator of genetic competence (MecA) DUF5094 PF17015.5 ETO09549.1 - 2.7 8.1 9.9 0.4 10.8 5.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5094) RNA_pol_Rpc34 PF05158.12 ETO09550.1 - 7.7e-22 78.1 5.8 1.3e-10 41.2 1.4 3.3 3 0 0 3 3 3 3 RNA polymerase Rpc34 subunit Rio2_N PF09202.11 ETO09550.1 - 0.028 14.6 1.7 0.21 11.8 0.5 2.5 2 0 0 2 2 2 0 Rio2, N-terminal SMG1 PF15785.5 ETO09550.1 - 0.04 12.3 1.0 0.079 11.3 1.0 1.4 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 DUF3306 PF11748.8 ETO09550.1 - 0.24 12.3 2.6 6.2 7.7 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) DUF3687 PF12459.8 ETO09550.1 - 0.27 10.8 5.1 0.27 10.8 3.6 1.8 1 1 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein Helicase_C PF00271.31 ETO09551.1 - 5.2e-26 91.2 0.2 8.7e-26 90.5 0.2 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain UPF0262 PF06793.12 ETO09551.1 - 0.037 14.1 0.0 0.06 13.4 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) 3A PF00803.18 ETO09551.1 - 0.066 12.5 0.1 0.11 11.7 0.1 1.3 1 0 0 1 1 1 0 3A/RNA2 movement protein family Elongin_A PF06881.11 ETO09552.1 - 0.026 15.1 2.6 0.028 14.9 1.3 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription factor SIII (Elongin) subunit A RNR_Alpha PF17975.1 ETO09552.1 - 0.029 14.9 0.7 0.075 13.5 0.7 1.7 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain Phage_int_SAM_5 PF13102.6 ETO09552.1 - 0.038 14.3 0.7 0.038 14.3 0.7 2.3 2 0 0 2 2 2 0 Phage integrase SAM-like domain DUF285 PF03382.14 ETO09552.1 - 0.053 13.3 4.5 0.12 12.1 4.4 1.5 1 1 0 1 1 1 0 Mycoplasma protein of unknown function, DUF285 U-box PF04564.15 ETO09553.1 - 3.3e-27 94.4 0.5 5e-27 93.9 0.5 1.3 1 0 0 1 1 1 1 U-box domain Pex14_N PF04695.13 ETO09554.1 - 2.8 8.6 10.7 5.4 7.7 0.3 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RP-C_C PF11800.8 ETO09554.1 - 5.4 7.0 9.1 3.9 7.5 1.0 2.1 2 0 0 2 2 2 0 Replication protein C C-terminal region Presenilin PF01080.17 ETO09555.1 - 0.07 11.9 5.8 0.1 11.3 5.8 1.2 1 0 0 1 1 1 0 Presenilin AAR2 PF05282.11 ETO09555.1 - 0.11 11.9 4.0 0.18 11.2 4.0 1.3 1 0 0 1 1 1 0 AAR2 protein CENP-B_dimeris PF09026.10 ETO09555.1 - 0.88 10.0 3.4 1.9 8.9 0.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SLC12 PF03522.15 ETO09555.1 - 1.2 8.1 7.2 1.8 7.5 7.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CSG2 PF16965.5 ETO09555.1 - 4.4 6.1 5.0 7 5.5 5.0 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator DUF3089 PF11288.8 ETO09556.1 - 2.4e-30 105.6 0.0 4e-30 104.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) Pkinase PF00069.25 ETO09557.1 - 1.3e-22 80.4 3.4 6.8e-12 45.3 0.0 2.8 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09557.1 - 7.1e-15 55.0 0.0 1.4e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO09557.1 - 8.4e-07 29.1 0.1 1.4e-06 28.4 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Thioredoxin_2 PF13098.6 ETO09557.1 - 0.12 12.8 0.3 0.23 11.9 0.3 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain O-antigen_lig PF13425.6 ETO09557.1 - 1.1 8.0 2.5 1.8 7.3 2.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CTU2 PF10288.9 ETO09557.1 - 2.7 8.3 6.3 18 5.6 6.2 2.4 1 1 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Ank_2 PF12796.7 ETO09558.1 - 1.9e-23 82.8 0.2 9.1e-11 42.2 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO09558.1 - 1.9e-16 60.2 4.8 4.2e-07 30.4 0.1 4.0 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO09558.1 - 4.5e-15 55.5 1.2 1.5e-08 34.7 0.2 3.1 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO09558.1 - 3.6e-14 52.5 1.8 4.4e-05 23.7 0.0 4.7 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 ETO09558.1 - 6.1e-13 47.7 1.1 0.00037 20.7 0.2 4.8 5 0 0 5 5 5 2 Ankyrin repeat DUF249 PF03158.13 ETO09558.1 - 0.037 13.7 0.0 0.77 9.4 0.0 2.4 2 0 0 2 2 2 0 Multigene family 530 protein Macoilin PF09726.9 ETO09558.1 - 0.89 8.0 18.4 1.1 7.7 18.4 1.1 1 0 0 1 1 1 0 Macoilin family Ank_2 PF12796.7 ETO09559.1 - 4.8e-10 39.9 0.0 3.2e-05 24.4 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO09559.1 - 7.7e-06 26.4 0.1 0.71 10.5 0.0 4.4 3 2 2 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO09559.1 - 1.4e-05 25.1 0.0 3.4 8.6 0.0 5.4 5 0 0 5 5 5 1 Ankyrin repeat Ank PF00023.30 ETO09559.1 - 0.11 13.0 0.0 50 4.6 0.0 4.0 4 0 0 4 4 4 0 Ankyrin repeat WSK PF03832.13 ETO09561.1 - 0.022 14.5 0.6 0.06 13.0 0.6 1.8 1 0 0 1 1 1 0 WSK motif DUF4407 PF14362.6 ETO09561.1 - 8.8 5.6 11.4 12 5.1 11.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EF-hand_1 PF00036.32 ETO09562.1 - 1.9e-30 102.1 17.2 8.5e-10 37.5 0.1 5.0 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 ETO09562.1 - 3.2e-28 97.3 9.4 1.1e-13 50.8 0.2 3.3 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 ETO09562.1 - 6.2e-27 93.8 5.3 3.1e-14 53.1 1.1 2.4 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO09562.1 - 9.2e-21 72.0 12.8 4e-09 35.7 0.1 5.2 5 1 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 ETO09562.1 - 4.2e-19 67.1 10.5 1.1e-06 27.8 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_9 PF14658.6 ETO09562.1 - 1.6e-11 44.4 0.1 5.7e-07 29.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETO09562.1 - 3.3e-06 27.0 1.6 0.027 14.4 0.1 2.7 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO09562.1 - 6.6e-05 23.2 0.0 0.15 12.4 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region UPF0154 PF03672.13 ETO09562.1 - 0.00022 21.2 0.0 0.056 13.5 0.0 2.7 2 1 1 3 3 3 1 Uncharacterised protein family (UPF0154) EF-hand_11 PF08976.11 ETO09562.1 - 0.00038 21.3 0.0 0.018 15.9 0.0 2.3 1 1 1 2 2 2 1 EF-hand domain RNA_pol_Rpb4 PF03874.16 ETO09562.1 - 0.00072 19.9 0.6 0.95 9.8 0.0 2.7 2 1 0 2 2 2 2 RNA polymerase Rpb4 Poly_export PF02563.16 ETO09562.1 - 0.0012 19.0 0.3 0.64 10.3 0.1 3.1 1 1 2 3 3 3 1 Polysaccharide biosynthesis/export protein Dockerin_1 PF00404.18 ETO09562.1 - 0.0039 17.4 6.3 0.11 12.7 0.4 3.3 1 1 3 4 4 4 1 Dockerin type I domain EFhand_Ca_insen PF08726.10 ETO09562.1 - 0.0071 16.4 0.1 0.023 14.8 0.0 2.0 2 0 0 2 2 2 1 Ca2+ insensitive EF hand TerB PF05099.13 ETO09562.1 - 0.025 14.5 0.2 0.28 11.1 0.0 2.2 1 1 1 2 2 2 0 Tellurite resistance protein TerB Spore_III_AB PF09548.10 ETO09562.1 - 0.048 13.8 0.6 0.099 12.8 0.1 1.7 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) MotA_activ PF09114.10 ETO09562.1 - 0.075 13.2 0.2 0.37 11.0 0.0 2.0 1 1 1 2 2 2 0 Transcription factor MotA, activation domain DUF2267 PF10025.9 ETO09562.1 - 0.1 12.9 0.1 1.7 8.9 0.1 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) DUF327 PF03885.13 ETO09562.1 - 0.29 11.1 5.0 0.74 9.8 0.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF327) Glyco_hydro_3_C PF01915.22 ETO09563.1 - 1.6e-12 47.8 1.7 8.2e-08 32.4 0.0 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ETO09563.1 - 5e-11 42.5 0.2 1.2e-10 41.4 0.2 1.6 1 0 0 1 1 1 1 Fibronectin type III-like domain PAN_4 PF14295.6 ETO09563.1 - 0.00095 19.0 5.1 0.0024 17.7 5.1 1.7 1 0 0 1 1 1 1 PAN domain DUF11 PF01345.18 ETO09563.1 - 0.0069 16.7 1.0 0.021 15.1 0.9 1.8 2 0 0 2 2 2 1 Domain of unknown function DUF11 EMA PF02488.15 ETO09564.1 - 0.06 13.0 0.1 0.08 12.6 0.1 1.1 1 0 0 1 1 1 0 Merozoite Antigen WD40 PF00400.32 ETO09565.1 - 8.6e-68 222.6 18.5 4.9e-10 39.8 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09565.1 - 4.1e-22 78.3 4.5 7.4e-05 23.0 0.0 7.1 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09565.1 - 1.5e-15 57.0 2.7 0.039 12.9 0.0 6.9 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09565.1 - 1.7e-10 40.8 1.2 0.0044 16.4 0.1 3.7 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO09565.1 - 2.1e-08 33.3 0.8 0.64 8.6 0.0 5.2 2 1 3 5 5 5 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO09565.1 - 2.1e-06 27.8 2.3 2.5 8.2 0.2 4.7 1 1 3 4 4 4 2 Family of unknown function (DUF5570) PD40 PF07676.12 ETO09565.1 - 3e-05 23.8 6.2 1.2 9.1 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO09565.1 - 0.0006 18.7 7.9 0.23 10.1 0.8 3.5 2 1 2 4 4 4 2 Nup133 N terminal like NodS PF05401.11 ETO09565.1 - 0.0047 16.6 0.3 0.8 9.3 0.0 3.2 3 1 0 3 3 3 1 Nodulation protein S (NodS) Cytochrom_D1 PF02239.16 ETO09565.1 - 0.0059 15.2 0.3 0.088 11.3 0.0 2.7 1 1 1 3 3 3 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO09565.1 - 0.0096 15.3 2.0 3.4 6.9 0.1 3.7 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO09565.1 - 0.011 15.4 0.1 4.1 7.2 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO09566.1 - 8.9e-48 159.3 16.2 5.2e-09 36.6 0.1 7.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09566.1 - 2.7e-18 66.1 0.7 0.13 12.6 0.0 7.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09566.1 - 3.5e-15 55.8 0.4 0.08 11.9 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO09566.1 - 7.8e-07 28.9 9.2 3.9 7.5 0.0 7.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat NHL PF01436.21 ETO09566.1 - 0.0038 17.2 0.3 1 9.6 0.0 3.5 3 0 0 3 3 3 1 NHL repeat Nup160 PF11715.8 ETO09566.1 - 0.0047 15.6 7.0 1.4 7.5 0.0 4.3 1 1 2 4 4 4 1 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO09566.1 - 0.011 14.5 0.1 1 8.1 0.0 3.2 1 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PH_TFIIH PF08567.11 ETO09566.1 - 0.051 13.9 0.7 25 5.3 0.0 3.9 4 1 1 5 5 5 0 TFIIH p62 subunit, N-terminal domain NodS PF05401.11 ETO09566.1 - 0.13 11.8 0.0 4 7.0 0.0 2.9 2 1 2 4 4 4 0 Nodulation protein S (NodS) Proteasome_A_N PF10584.9 ETO09566.1 - 0.17 11.6 7.0 50 3.7 0.0 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature BRCT_2 PF16589.5 ETO09567.1 - 0.042 14.3 0.4 0.1 13.0 0.1 1.8 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Pribosyltran_N PF13793.6 ETO09567.1 - 0.05 13.6 0.1 0.078 12.9 0.1 1.3 1 0 0 1 1 1 0 N-terminal domain of ribose phosphate pyrophosphokinase bVLRF1 PF18826.1 ETO09567.1 - 0.061 13.2 0.1 0.08 12.8 0.1 1.2 1 0 0 1 1 1 0 bacteroidetes VLRF1 release factor DUF3740 PF12548.8 ETO09567.1 - 0.21 12.0 4.6 0.33 11.4 4.6 1.4 1 1 0 1 1 1 0 Sulfatase protein RNA_pol_Rpb2_6 PF00562.28 ETO09568.1 - 6.4e-70 236.2 0.0 4.2e-68 230.2 0.0 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 6 AF-4 PF05110.13 ETO09568.1 - 0.096 10.8 12.3 0.12 10.5 12.3 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 ETO09568.1 - 1.1 8.8 18.4 1.6 8.3 18.4 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein IMUP PF15761.5 ETO09568.1 - 1.8 9.3 11.0 3 8.6 11.0 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein IQCJ-SCHIP1 PF15157.6 ETO09568.1 - 1.9 8.3 5.5 3.3 7.5 5.5 1.3 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif RAP1 PF07218.11 ETO09568.1 - 2.9 6.1 6.1 3.8 5.7 6.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4964 PF16334.5 ETO09569.1 - 0.06 12.9 0.1 0.18 11.3 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4964) Cadherin_C_2 PF16492.5 ETO09569.1 - 0.12 13.1 0.5 0.2 12.4 0.5 1.8 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal WD40 PF00400.32 ETO09570.1 - 4.2e-72 236.3 18.1 4.8e-10 39.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09570.1 - 2.9e-22 78.8 1.9 4.4e-05 23.7 0.1 5.8 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09570.1 - 1.5e-17 63.6 0.5 0.0028 16.6 0.0 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09570.1 - 7.8e-09 35.3 0.2 0.13 11.6 0.0 3.4 1 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO09570.1 - 3e-08 32.8 7.1 0.036 12.7 0.1 5.3 1 1 5 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO09570.1 - 7.7e-08 32.1 9.0 3.9 7.5 0.1 7.0 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO09570.1 - 4.4e-07 28.8 1.2 0.0018 16.9 0.2 3.3 1 1 0 3 3 3 2 Cytochrome D1 heme domain VID27 PF08553.10 ETO09570.1 - 0.00057 19.1 0.1 0.31 10.0 0.1 2.4 1 1 1 2 2 2 2 VID27 C-terminal WD40-like domain Nucleoporin_N PF08801.11 ETO09570.1 - 0.0013 17.6 8.3 0.057 12.1 1.2 3.5 1 1 2 3 3 3 3 Nup133 N terminal like DUF1258 PF06869.12 ETO09570.1 - 0.0096 15.4 0.2 0.066 12.7 0.1 2.3 1 1 2 3 3 3 1 Protein of unknown function (DUF1258) Nop10p PF04135.12 ETO09570.1 - 0.042 13.9 0.0 0.4 10.8 0.0 2.5 2 0 0 2 2 2 0 Nucleolar RNA-binding protein, Nop10p family nos_propeller PF18764.1 ETO09570.1 - 0.052 13.5 0.1 17 5.4 0.0 4.3 4 1 0 5 5 5 0 Nitrous oxide reductase propeller repeat AcetylCoA_hyd_C PF13336.6 ETO09570.1 - 0.1 12.5 0.0 15 5.5 0.0 3.2 3 0 0 3 3 3 0 Acetyl-CoA hydrolase/transferase C-terminal domain Ran_BP1 PF00638.18 ETO09571.1 - 2.7e-06 27.6 2.3 2.9e-06 27.5 0.2 1.9 2 0 0 2 2 2 1 RanBP1 domain P34-Arc PF04045.14 ETO09571.1 - 0.015 15.0 0.2 0.028 14.1 0.2 1.5 1 0 0 1 1 1 0 Arp2/3 complex, 34 kD subunit p34-Arc Ran_BP1 PF00638.18 ETO09572.1 - 5.4e-10 39.6 0.1 9.4e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 RanBP1 domain DUF1566 PF07603.11 ETO09573.1 - 0.062 13.7 0.1 0.2 12.1 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1566) Nuc_sug_transp PF04142.15 ETO09575.1 - 3.5e-32 111.8 19.4 1.6e-20 73.5 0.7 2.1 1 1 0 2 2 2 2 Nucleotide-sugar transporter EamA PF00892.20 ETO09575.1 - 2.4e-06 27.7 0.4 2.4e-06 27.7 0.4 3.7 2 1 1 3 3 3 1 EamA-like transporter family DUF4386 PF14329.6 ETO09575.1 - 0.034 14.0 1.0 0.034 14.0 1.0 3.0 1 1 2 3 3 3 0 Domain of unknown function (DUF4386) MerC PF03203.14 ETO09575.1 - 1.3 9.5 8.9 1.4 9.4 5.0 2.4 2 1 0 2 2 2 0 MerC mercury resistance protein LptF_LptG PF03739.14 ETO09576.1 - 5.2 5.8 11.5 3.2 6.5 9.4 1.6 1 1 1 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG YIF1 PF03878.15 ETO09577.1 - 0.2 11.2 2.9 0.3 10.6 2.9 1.2 1 0 0 1 1 1 0 YIF1 Pkinase PF00069.25 ETO09578.1 - 2.5e-26 92.6 0.1 3e-26 92.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09578.1 - 2.3e-10 40.2 0.3 3.3e-10 39.7 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO09578.1 - 0.0075 15.1 0.0 0.0092 14.8 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase IPK PF03770.16 ETO09578.1 - 0.017 15.0 0.1 0.037 13.9 0.1 1.5 2 0 0 2 2 2 0 Inositol polyphosphate kinase DUF2207 PF09972.9 ETO09579.1 - 0.099 11.4 0.0 0.11 11.3 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Serinc PF03348.15 ETO09580.1 - 0.63 8.9 1.5 0.65 8.9 1.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Presenilin PF01080.17 ETO09580.1 - 0.64 8.7 8.1 0.66 8.7 8.1 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO09580.1 - 0.94 8.6 3.2 0.94 8.6 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO09580.1 - 2.3 9.2 10.6 5.7 8.0 10.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 ETO09580.1 - 3.9 6.4 4.6 4.1 6.3 4.6 1.1 1 0 0 1 1 1 0 CLN3 protein Sec62 PF03839.16 ETO09580.1 - 4.9 6.6 12.1 5.5 6.4 12.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Sec23_trunk PF04811.15 ETO09581.1 - 1.7e-08 34.3 0.2 1.1e-07 31.7 0.2 2.3 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain dsRBD2 PF17842.1 ETO09581.1 - 0.013 15.7 0.4 0.022 15.0 0.4 1.3 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 VWA_2 PF13519.6 ETO09581.1 - 0.029 15.0 0.1 1.3 9.7 0.1 2.7 1 1 0 1 1 1 0 von Willebrand factor type A domain zf-Sec23_Sec24 PF04810.15 ETO09582.1 - 0.00033 20.7 0.6 0.00077 19.5 0.1 1.8 2 0 0 2 2 2 1 Sec23/Sec24 zinc finger Secretin_N_2 PF07655.13 ETO09582.1 - 0.028 15.0 11.4 0.062 13.8 11.4 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4834 PF16118.5 ETO09582.1 - 4.6 8.3 8.6 1.4 9.9 5.2 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Sec62 PF03839.16 ETO09582.1 - 6.8 6.1 6.6 2.8 7.4 2.7 2.0 2 0 0 2 2 2 0 Translocation protein Sec62 Ank_2 PF12796.7 ETO09583.1 - 0.0033 18.0 0.0 0.49 11.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO09583.1 - 0.082 13.4 0.0 0.28 11.7 0.0 1.9 2 0 0 2 2 1 0 Ankyrin repeat CDC45 PF02724.14 ETO09583.1 - 0.31 9.3 10.7 0.42 8.8 10.7 1.1 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 ETO09583.1 - 0.55 9.8 18.9 1.1 8.8 18.2 1.8 2 0 0 2 2 2 0 PPP4R2 Nop14 PF04147.12 ETO09583.1 - 0.7 8.0 18.0 1 7.5 18.0 1.1 1 0 0 1 1 1 0 Nop14-like family Astro_capsid_p PF12226.8 ETO09583.1 - 1.4 7.9 14.1 2.6 7.1 14.1 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein BUD22 PF09073.10 ETO09583.1 - 4.2 6.6 14.2 6.3 6.0 14.2 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ETO09583.1 - 4.3 6.7 16.7 6.5 6.1 16.7 1.2 1 0 0 1 1 1 0 SDA1 Pox_Ag35 PF03286.14 ETO09583.1 - 5.1 6.8 14.4 9.8 5.9 14.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ETO09583.1 - 5.8 6.6 10.0 18 5.0 10.0 1.9 1 0 0 1 1 1 0 FAM176 family SURF2 PF05477.11 ETO09583.1 - 7.7 6.1 10.5 12 5.5 10.5 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Vfa1 PF08432.10 ETO09583.1 - 8.2 6.7 10.4 21 5.4 10.4 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 WD40 PF00400.32 ETO09584.1 - 1.9e-43 145.6 27.6 4.6e-07 30.4 0.3 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09584.1 - 6.9e-13 48.7 1.2 0.076 13.3 0.0 5.3 4 1 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09584.1 - 3.5e-09 35.9 7.5 0.039 12.6 0.1 5.8 1 1 5 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09584.1 - 9.9e-06 25.1 7.0 0.00064 19.1 0.5 3.6 2 2 2 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO09585.1 - 4.3e-10 40.0 0.6 7.8e-10 39.2 0.6 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09585.1 - 0.00088 19.5 0.0 0.0019 18.4 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1435 PF07256.12 ETO09586.1 - 0.6 10.2 5.1 5.1 7.3 0.2 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) YajC PF02699.15 ETO09587.1 - 0.023 14.6 0.1 0.039 13.8 0.1 1.5 1 1 0 1 1 1 0 Preprotein translocase subunit PriA_3primeBD PF17764.1 ETO09588.1 - 0.029 14.3 0.1 0.053 13.4 0.1 1.3 1 0 0 1 1 1 0 3′ DNA-binding domain (3′BD) Wzy_C PF04932.15 ETO09588.1 - 0.13 11.9 1.1 0.3 10.7 0.7 1.7 2 0 0 2 2 2 0 O-Antigen ligase B56 PF01603.20 ETO09590.1 - 0.002 17.1 0.8 0.0027 16.8 0.8 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) HEAT PF02985.22 ETO09590.1 - 0.0031 17.6 0.2 0.041 14.1 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat BP28CT PF08146.12 ETO09590.1 - 0.0075 16.1 0.2 0.015 15.1 0.0 1.5 2 0 0 2 2 2 1 BP28CT (NUC211) domain DUF3385 PF11865.8 ETO09590.1 - 0.0097 15.8 0.8 0.52 10.2 0.0 3.0 1 1 1 2 2 2 1 Domain of unknown function (DUF3385) RICTOR_V PF14668.6 ETO09590.1 - 0.014 15.7 0.0 0.038 14.2 0.0 1.8 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, domain 5 DRIM PF07539.12 ETO09590.1 - 0.045 12.0 0.0 0.08 11.2 0.0 1.5 1 0 0 1 1 1 0 Down-regulated in metastasis Rap1a PF18602.1 ETO09590.1 - 0.097 13.0 0.6 0.19 12.0 0.3 1.7 2 0 0 2 2 2 0 Rap1a immunity proteins Importin_rep_4 PF18808.1 ETO09591.1 - 1.7e-14 53.9 0.2 3.2e-12 46.6 0.0 4.1 3 1 1 4 4 4 1 Importin repeat HEAT_EZ PF13513.6 ETO09591.1 - 5.4e-10 39.5 1.9 0.17 12.4 0.2 5.9 5 0 0 5 5 5 3 HEAT-like repeat HEAT_2 PF13646.6 ETO09591.1 - 1.4e-09 38.2 0.3 0.0074 16.7 0.0 5.5 5 1 0 5 5 5 2 HEAT repeats HEAT PF02985.22 ETO09591.1 - 2.6e-06 27.2 4.2 0.082 13.2 0.0 6.4 7 0 0 7 7 6 1 HEAT repeat RIX1 PF08167.12 ETO09591.1 - 5.4e-05 23.0 0.0 0.011 15.5 0.0 3.3 4 0 0 4 4 4 1 rRNA processing/ribosome biogenesis Ecm29 PF13001.7 ETO09591.1 - 0.0018 17.1 0.8 0.053 12.2 0.2 2.9 3 0 0 3 3 3 1 Proteasome stabiliser Vac14_Fab1_bd PF12755.7 ETO09591.1 - 0.02 15.5 3.8 6.9 7.3 0.1 4.3 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO09591.1 - 0.042 13.4 4.8 1.2 8.6 0.2 4.2 4 1 1 5 5 5 0 CLASP N terminal Opi1 PF08618.10 ETO09591.1 - 0.063 12.5 0.1 0.12 11.6 0.1 1.3 1 0 0 1 1 1 0 Transcription factor Opi1 V-ATPase_H_C PF11698.8 ETO09591.1 - 0.085 13.0 5.7 8 6.6 0.1 4.2 4 1 0 4 4 4 0 V-ATPase subunit H ArAE_1_C PF11728.8 ETO09591.1 - 0.12 12.4 5.0 0.35 10.8 5.0 1.9 1 0 0 1 1 1 0 Putative aromatic acid exporter C-terminal domain Arm PF00514.23 ETO09591.1 - 0.13 12.4 2.5 3 8.0 0.4 3.4 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat HEAT_PBS PF03130.16 ETO09591.1 - 0.24 12.2 2.0 2.1 9.3 0.0 3.8 4 0 0 4 4 2 0 PBS lyase HEAT-like repeat LAP1C PF05609.12 ETO09592.1 - 2.4 7.2 27.1 3.8 6.5 27.1 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BUD22 PF09073.10 ETO09592.1 - 2.5 7.4 46.1 3.8 6.7 34.3 2.1 2 0 0 2 2 2 0 BUD22 Pkinase PF00069.25 ETO09593.1 - 4.2e-14 52.6 0.0 4.9e-14 52.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09593.1 - 5e-07 29.3 0.0 6.3e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Ras PF00071.22 ETO09594.1 - 1.9e-20 73.1 0.1 2.3e-20 72.8 0.1 1.0 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETO09594.1 - 0.004 16.6 0.0 0.005 16.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family CH PF00307.31 ETO09595.1 - 1.6e-28 99.1 9.9 9.2e-15 54.8 1.4 5.0 4 1 0 4 4 4 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO09595.1 - 2.3e-07 30.6 1.7 9.2e-06 25.4 0.1 3.4 3 0 0 3 3 3 1 CAMSAP CH domain CH_2 PF06294.11 ETO09595.1 - 5e-06 26.6 0.3 2.1e-05 24.5 0.3 2.2 1 0 0 1 1 1 1 CH-like domain in sperm protein CUT PF02376.15 ETO09595.1 - 0.023 14.8 0.0 0.2 11.8 0.0 2.3 1 1 0 1 1 1 0 CUT domain DUF755 PF05501.11 ETO09596.1 - 0.023 15.0 18.1 0.023 15.0 18.1 3.2 4 1 0 4 4 4 0 Domain of unknown function (DUF755) Dsh_C PF12316.8 ETO09596.1 - 4.7 7.6 16.4 9.3 6.6 16.4 1.5 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4551 PF15087.6 ETO09596.1 - 5.4 5.7 14.2 6.8 5.4 14.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DNA_pol_E_B PF04042.16 ETO09597.1 - 4.4e-21 75.2 0.2 5.8e-21 74.8 0.2 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B RabGAP-TBC PF00566.18 ETO09598.1 - 4.8e-14 52.5 4.9 4.8e-14 52.5 4.9 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.29 ETO09598.1 - 1.4e-09 38.4 0.2 4.5e-09 36.8 0.0 1.9 2 0 0 2 2 2 1 PH domain DUF615 PF04751.14 ETO09598.1 - 0.033 14.2 0.0 0.051 13.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF615) DUF4200 PF13863.6 ETO09598.1 - 0.1 13.0 1.4 0.19 12.2 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4770 PF15994.5 ETO09601.1 - 0.052 13.8 4.7 0.071 13.3 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Kinesin PF00225.23 ETO09602.1 - 1.4e-32 113.0 0.4 1.6e-32 112.7 0.4 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO09602.1 - 5.2e-21 75.1 1.2 6.9e-21 74.7 1.2 1.1 1 0 0 1 1 1 1 Microtubule binding DUF4448 PF14610.6 ETO09603.1 - 0.0024 17.7 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) TRIQK PF15168.6 ETO09603.1 - 0.083 12.8 4.8 0.2 11.6 1.0 2.3 1 1 1 2 2 2 0 Triple QxxK/R motif-containing protein family CBP4 PF07960.11 ETO09603.1 - 0.18 11.7 3.9 0.31 10.9 3.9 1.3 1 0 0 1 1 1 0 CBP4 DUF572 PF04502.13 ETO09604.1 - 0.53 9.9 9.2 0.66 9.5 9.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF2981 PF11200.8 ETO09604.1 - 1.2 8.8 4.5 1.4 8.6 4.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Med3 PF11593.8 ETO09604.1 - 8.4 5.5 25.1 12 4.9 25.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Atx10homo_assoc PF09759.9 ETO09605.1 - 8.8e-07 28.9 7.9 7.5e-05 22.7 0.7 5.0 5 0 0 5 5 5 1 Spinocerebellar ataxia type 10 protein domain Arm PF00514.23 ETO09605.1 - 4e-05 23.5 7.4 21 5.3 0.0 8.1 8 1 0 8 8 8 0 Armadillo/beta-catenin-like repeat Neurochondrin PF05536.11 ETO09605.1 - 0.00015 20.3 2.9 0.049 12.0 0.0 4.1 5 0 0 5 5 5 2 Neurochondrin DUF3361 PF11841.8 ETO09605.1 - 0.0015 18.5 1.7 3.8 7.4 0.0 4.2 5 1 0 5 5 5 2 Domain of unknown function (DUF3361) DUF5578 PF17741.1 ETO09605.1 - 0.0049 16.3 0.1 1.1 8.6 0.1 3.1 3 0 0 3 3 3 1 Family of unknown function (DUF5578) mRNA_stabil PF13929.6 ETO09605.1 - 0.0066 15.5 0.0 0.031 13.3 0.0 2.1 2 0 0 2 2 2 1 mRNA stabilisation Proteasom_PSMB PF10508.9 ETO09605.1 - 0.014 13.9 0.1 0.62 8.5 0.0 3.5 4 0 0 4 4 4 0 Proteasome non-ATPase 26S subunit DNTTIP1_dimer PF18192.1 ETO09605.1 - 0.034 14.5 1.7 1.1 9.7 0.1 3.1 2 0 0 2 2 2 0 DNTTIP1 dimerisation domain RNase_PH_C PF03725.15 ETO09605.1 - 0.18 11.8 0.8 1 9.4 0.5 2.4 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 BAF1_ABF1 PF04684.13 ETO09605.1 - 3.1 6.8 21.6 5.9 5.8 21.6 1.4 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor COG7 PF10191.9 ETO09606.1 - 2.3e-17 62.6 2.3 4.6e-16 58.2 2.3 2.0 1 1 0 1 1 1 1 Golgi complex component 7 (COG7) GlutR_dimer PF00745.20 ETO09606.1 - 0.11 12.9 4.9 0.13 12.7 1.1 2.4 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain COG7 PF10191.9 ETO09607.1 - 0.0013 17.1 0.1 0.0016 16.8 0.1 1.2 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) COG7 PF10191.9 ETO09608.1 - 2.6e-24 85.5 12.5 3.8e-24 85.0 12.5 1.1 1 0 0 1 1 1 1 Golgi complex component 7 (COG7) DHR10 PF18595.1 ETO09608.1 - 0.0001 22.4 6.4 0.0003 20.8 6.4 1.8 1 0 0 1 1 1 1 Designed helical repeat protein 10 domain FUSC PF04632.12 ETO09608.1 - 0.091 11.3 0.2 0.12 10.9 0.2 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family HIP1_clath_bdg PF16515.5 ETO09608.1 - 0.46 11.1 14.7 0.14 12.7 5.6 3.1 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Baculo_PEP_C PF04513.12 ETO09608.1 - 0.74 9.8 11.3 2.6 8.1 6.0 2.5 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4763 PF15960.5 ETO09608.1 - 1.8 7.8 20.2 0.55 9.5 1.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) NPV_P10 PF05531.12 ETO09608.1 - 4.7 7.8 12.3 2.1 8.9 3.1 2.9 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Condensin2nSMC PF12422.8 ETO09609.1 - 0.028 14.6 1.3 0.054 13.7 1.3 1.6 1 1 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit Tim54 PF11711.8 ETO09609.1 - 0.028 13.2 2.2 0.036 12.9 2.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF3446 PF11928.8 ETO09609.1 - 0.03 14.6 18.2 0.27 11.6 4.1 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain SR-25 PF10500.9 ETO09609.1 - 1.2 8.7 22.8 0.059 13.0 5.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein SDP_N PF12278.8 ETO09609.1 - 3.3 7.9 10.9 5.9 7.0 5.5 2.3 2 0 0 2 2 2 0 Sex determination protein N terminal CorA PF01544.18 ETO09610.1 - 1.8e-07 30.8 1.3 2.4e-07 30.4 1.3 1.1 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein GWT1 PF06423.12 ETO09610.1 - 0.039 14.1 0.2 0.046 13.9 0.2 1.1 1 0 0 1 1 1 0 GWT1 Annexin PF00191.20 ETO09611.1 - 7.4e-30 102.8 5.1 1.4e-11 44.3 0.0 4.7 5 0 0 5 5 5 3 Annexin EF-hand_1 PF00036.32 ETO09611.1 - 0.00012 21.3 0.1 0.00049 19.5 0.0 2.1 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO09611.1 - 0.015 15.2 0.0 0.068 13.1 0.0 2.2 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 ETO09611.1 - 0.025 14.0 0.1 0.097 12.2 0.1 2.0 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 ETO09611.1 - 0.05 14.1 0.0 0.2 12.1 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain pair CBS PF00571.28 ETO09612.1 - 1.5e-08 34.9 0.1 0.0017 18.7 0.0 2.7 2 1 1 3 3 3 2 CBS domain SAM_1 PF00536.30 ETO09613.1 - 1.4e-08 35.1 0.7 2.7e-08 34.1 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO09613.1 - 7.5e-08 32.4 0.3 3.2e-07 30.3 0.1 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO09613.1 - 0.00047 20.1 0.0 0.00088 19.2 0.0 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain fn3 PF00041.21 ETO09615.1 - 7.2e-09 35.9 0.6 0.013 15.8 0.0 3.5 3 0 0 3 3 3 2 Fibronectin type III domain PDZ PF00595.24 ETO09615.1 - 1.9e-05 24.9 0.0 5.3e-05 23.5 0.0 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO09615.1 - 0.00034 20.4 0.1 0.0013 18.5 0.1 2.0 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 ETO09615.1 - 0.0027 18.0 0.2 0.0079 16.5 0.2 1.8 1 0 0 1 1 1 1 PDZ domain Ax_dynein_light PF10211.9 ETO09616.1 - 1.2e-59 201.4 15.2 1.7e-59 200.9 15.2 1.2 1 0 0 1 1 1 1 Axonemal dynein light chain Peptidase_S30 PF01577.16 ETO09616.1 - 0.044 13.4 8.5 1.1 8.8 4.1 2.2 2 0 0 2 2 2 0 Potyvirus P1 protease DUF349 PF03993.12 ETO09616.1 - 0.076 13.3 1.1 0.076 13.3 1.1 3.3 4 0 0 4 4 4 0 Domain of Unknown Function (DUF349) Seryl_tRNA_N PF02403.22 ETO09616.1 - 8.2 6.7 12.9 0.25 11.6 4.0 2.6 3 0 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain WD40 PF00400.32 ETO09617.1 - 3.9e-41 138.3 7.4 2.1e-08 34.7 0.4 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09617.1 - 1.9e-14 53.7 2.0 0.00076 19.7 0.1 5.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09617.1 - 9.9e-06 24.5 4.7 0.89 8.1 0.0 4.3 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09617.1 - 0.00084 18.7 1.6 0.13 11.5 0.0 3.1 2 1 0 3 3 3 2 WD40-like domain PQQ PF01011.21 ETO09617.1 - 0.0027 17.6 0.1 13 5.9 0.0 3.8 4 0 0 4 4 4 2 PQQ enzyme repeat PQQ_2 PF13360.6 ETO09617.1 - 0.0031 17.1 0.1 1.2 8.6 0.1 2.2 1 1 1 2 2 2 2 PQQ-like domain Nucleoporin_N PF08801.11 ETO09617.1 - 0.0034 16.2 7.1 0.14 10.9 2.1 3.4 1 1 2 3 3 3 1 Nup133 N terminal like TPR_12 PF13424.6 ETO09618.1 - 8.2e-46 154.2 17.1 1.9e-14 53.7 0.8 4.6 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09618.1 - 3.1e-23 80.5 33.2 9.4e-08 31.6 1.3 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO09618.1 - 1.6e-21 75.4 0.0 0.00016 21.4 0.0 7.5 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09618.1 - 4.4e-19 67.0 28.5 0.00048 20.1 0.9 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09618.1 - 1.8e-12 46.3 24.8 0.00027 20.8 0.0 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09618.1 - 3e-11 42.5 11.0 0.0012 18.7 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09618.1 - 0.00016 21.3 8.7 0.059 13.1 0.1 5.2 5 1 0 5 5 5 1 TPR repeat TPR_17 PF13431.6 ETO09618.1 - 0.0014 18.9 6.3 0.32 11.5 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO09618.1 - 0.0031 17.7 14.4 0.023 14.9 3.5 3.8 4 0 0 4 4 3 2 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO09618.1 - 0.038 14.0 12.7 7.4 6.7 0.1 5.2 5 1 1 6 6 5 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO09618.1 - 0.06 14.0 8.6 1.8 9.3 0.1 5.5 6 0 0 6 6 6 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO09618.1 - 0.063 12.9 3.8 22 4.7 0.0 4.5 5 1 1 6 6 6 0 Helix-turn-helix bacterial domain Bactofilin PF04519.13 ETO09618.1 - 0.086 13.1 0.0 0.31 11.4 0.0 1.9 2 0 0 2 2 2 0 Polymer-forming cytoskeletal TPR_19 PF14559.6 ETO09618.1 - 0.13 12.8 0.4 36 4.9 0.0 3.5 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO09618.1 - 0.58 9.9 13.6 1.3 8.8 0.4 4.9 5 2 1 6 6 6 0 Domain of unknown function (DUF5113) WD40 PF00400.32 ETO09619.1 - 6.8e-71 232.4 15.7 4.3e-10 40.0 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09619.1 - 1.6e-21 76.4 6.6 0.004 17.4 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09619.1 - 2.7e-10 39.5 3.3 0.084 11.5 0.4 5.6 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09619.1 - 1.6e-09 37.5 2.8 0.0025 17.2 0.0 4.4 2 2 3 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 ETO09619.1 - 6.9e-09 35.1 0.3 1.9 7.3 0.0 6.2 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO09619.1 - 8.3e-06 24.6 1.4 0.0091 14.6 0.1 2.8 2 1 2 4 4 4 2 Cytochrome D1 heme domain Str_synth PF03088.16 ETO09619.1 - 0.0014 18.7 0.2 3.5 7.8 0.0 4.1 3 1 1 4 4 4 1 Strictosidine synthase PD40 PF07676.12 ETO09619.1 - 0.0014 18.5 0.7 20 5.3 0.0 5.1 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat NHL PF01436.21 ETO09619.1 - 0.0015 18.5 0.2 0.22 11.6 0.1 3.4 3 0 0 3 3 3 1 NHL repeat MIase PF02426.16 ETO09619.1 - 0.089 13.0 0.0 1.4e+02 2.8 0.0 4.3 5 0 0 5 5 5 0 Muconolactone delta-isomerase Big_7 PF17957.1 ETO09619.1 - 1.4 9.8 3.3 31 5.4 0.0 3.8 4 0 0 4 4 4 0 Bacterial Ig domain Peptidase_C14 PF00656.22 ETO09620.1 - 3.1e-13 50.2 1.9 7.4e-13 49.0 1.9 1.6 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO09620.1 - 4.3e-06 26.6 0.6 0.52 10.4 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO09620.1 - 4.1e-05 23.1 1.8 0.004 16.7 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO09620.1 - 0.0046 16.9 4.3 0.32 11.1 0.1 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO09620.1 - 0.095 13.0 2.5 1.5 9.2 0.0 3.4 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO09620.1 - 0.1 13.0 3.7 32 5.0 0.1 4.3 4 0 0 4 4 4 0 Kelch motif Mcp5_PH PF12814.7 ETO09622.1 - 0.033 14.3 0.9 0.072 13.2 0.1 2.0 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology Menin PF05053.13 ETO09622.1 - 1 7.6 12.7 1.8 6.8 12.7 1.4 1 0 0 1 1 1 0 Menin GTSE1_N PF15259.6 ETO09624.1 - 0.039 14.1 3.2 0.045 13.9 3.2 1.1 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 Peptidase_C97 PF05903.14 ETO09625.1 - 0.057 13.2 0.2 0.26 11.1 0.1 2.0 2 0 0 2 2 2 0 PPPDE putative peptidase domain Coilin_N PF15862.5 ETO09625.1 - 0.12 12.2 9.5 0.21 11.4 9.5 1.4 1 0 0 1 1 1 0 Coilin N-terminus CDC45 PF02724.14 ETO09625.1 - 1.3 7.2 10.0 1.7 6.9 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein ISK_Channel PF02060.15 ETO09626.1 - 0.011 15.4 2.1 0.024 14.3 2.1 1.6 1 0 0 1 1 1 0 Slow voltage-gated potassium channel LapA_dom PF06305.11 ETO09626.1 - 0.58 10.0 2.7 1.5 8.7 2.7 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain TMPIT PF07851.13 ETO09627.1 - 2e-90 303.3 18.1 2.4e-90 303.1 18.1 1.0 1 0 0 1 1 1 1 TMPIT-like protein DUF3584 PF12128.8 ETO09627.1 - 0.0043 14.7 1.2 0.0052 14.4 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF948 PF06103.11 ETO09627.1 - 0.005 17.1 0.8 0.005 17.1 0.8 2.4 3 0 0 3 3 2 1 Bacterial protein of unknown function (DUF948) SesA PF17107.5 ETO09627.1 - 0.0051 17.0 1.8 0.011 15.9 1.8 1.6 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases OmpH PF03938.14 ETO09627.1 - 0.009 16.4 6.4 0.019 15.3 6.4 1.5 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) APG17 PF04108.12 ETO09627.1 - 0.014 14.6 7.5 0.021 14.0 7.5 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Fmp27_WPPW PF10359.9 ETO09627.1 - 0.019 13.9 6.4 0.028 13.3 6.4 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain GOLGA2L5 PF15070.6 ETO09627.1 - 0.11 11.1 11.9 0.51 8.9 5.9 2.2 2 0 0 2 2 2 0 Putative golgin subfamily A member 2-like protein 5 Prefoldin_2 PF01920.20 ETO09627.1 - 0.17 11.8 11.9 0.41 10.6 1.2 2.6 1 1 0 2 2 2 0 Prefoldin subunit DASH_Dam1 PF08653.10 ETO09627.1 - 0.21 11.4 2.0 2 8.3 0.1 2.7 2 1 0 2 2 2 0 DASH complex subunit Dam1 Exonuc_VII_L PF02601.15 ETO09627.1 - 0.32 10.5 3.1 0.49 9.9 3.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3150 PF11348.8 ETO09627.1 - 0.36 10.0 6.3 1.8 7.7 3.3 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3150) Jnk-SapK_ap_N PF09744.9 ETO09627.1 - 0.61 10.3 9.0 1.2 9.4 9.0 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4515 PF14988.6 ETO09627.1 - 0.62 9.9 11.7 0.88 9.4 3.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4515) Med21 PF11221.8 ETO09627.1 - 0.7 10.1 5.0 0.21 11.8 0.9 2.0 2 0 0 2 2 2 0 Subunit 21 of Mediator complex Tweety PF04906.13 ETO09627.1 - 0.76 8.4 6.2 5.2 5.6 2.0 2.1 2 0 0 2 2 2 0 Tweety DUF4709 PF15821.5 ETO09627.1 - 1.3 9.3 10.1 0.36 11.1 5.2 2.5 3 1 0 3 3 2 0 Domain of unknown function (DUF4709) FlxA PF14282.6 ETO09627.1 - 1.4 8.9 13.6 0.13 12.3 5.9 2.2 2 0 0 2 2 2 0 FlxA-like protein CENP-H PF05837.12 ETO09627.1 - 1.5 9.3 8.5 3.3 8.1 8.5 1.6 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Laminin_II PF06009.12 ETO09627.1 - 1.5 8.8 7.1 1.9 8.5 5.2 2.0 2 1 0 2 2 2 0 Laminin Domain II DUF1043 PF06295.12 ETO09627.1 - 1.6 8.7 5.8 4.3 7.4 5.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) Fib_alpha PF08702.10 ETO09627.1 - 2.6 8.2 9.4 8.2 6.6 9.4 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 ETO09627.1 - 2.9 7.9 11.6 1 9.4 1.6 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein Med9 PF07544.13 ETO09627.1 - 3.9 7.6 8.8 0.45 10.6 1.2 2.8 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 PRKG1_interact PF15898.5 ETO09627.1 - 3.9 8.4 11.1 22 6.0 11.1 2.1 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DUF745 PF05335.13 ETO09627.1 - 5.3 6.7 7.1 3.8 7.2 5.2 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF745) V-SNARE PF05008.15 ETO09627.1 - 7.7 7.0 10.3 6.5 7.2 1.4 2.5 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Sec34 PF04136.15 ETO09627.1 - 8.6 6.2 13.3 1.1 9.1 4.2 2.7 2 1 1 3 3 3 0 Sec34-like family KxDL PF10241.9 ETO09627.1 - 9 6.7 12.4 5.7 7.3 2.5 2.9 2 1 1 3 3 2 0 Uncharacterized conserved protein COMM_domain PF07258.14 ETO09628.1 - 6.6e-18 64.6 1.3 1.2e-17 63.8 0.3 2.0 2 0 0 2 2 2 1 COMM domain RAC_head PF16717.5 ETO09628.1 - 0.27 12.2 4.9 0.21 12.6 0.9 2.5 3 0 0 3 3 3 0 Ribosome-associated complex head domain RNA_ligase PF09414.10 ETO09630.1 - 1.5e-18 67.6 0.1 3.1e-18 66.6 0.1 1.5 1 0 0 1 1 1 1 RNA ligase T4_Rnl2_C PF18043.1 ETO09630.1 - 1.1e-06 28.6 0.0 1.1e-06 28.6 0.0 2.5 2 0 0 2 2 2 1 T4 RNA ligase 2 C-terminal DUF5433 PF17498.2 ETO09630.1 - 0.011 16.0 1.0 0.04 14.1 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5433) RPN6_N PF18055.1 ETO09631.1 - 7e-32 110.2 7.7 7.9e-32 110.1 3.1 2.5 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 ETO09631.1 - 1.6e-06 28.6 0.4 1.6e-06 28.6 0.4 2.5 2 1 0 2 2 2 1 PCI domain Sel1 PF08238.12 ETO09631.1 - 0.029 15.0 0.1 0.35 11.6 0.0 2.7 2 0 0 2 2 2 0 Sel1 repeat SNAP PF14938.6 ETO09631.1 - 0.057 12.8 5.1 0.038 13.4 0.9 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP WBS28 PF15164.6 ETO09632.1 - 0.47 9.7 4.1 0.17 11.1 1.6 1.5 2 0 0 2 2 2 0 Williams-Beuren syndrome chromosomal region 28 protein homologue Sulfatase PF00884.23 ETO09633.1 - 7.1e-44 150.4 0.0 1.5e-43 149.4 0.0 1.6 1 1 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 ETO09633.1 - 2.7e-17 63.6 0.1 5.2e-17 62.7 0.1 1.4 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 ETO09633.1 - 0.019 14.6 0.0 0.03 13.9 0.0 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase Prominin PF05478.11 ETO09635.1 - 8e-10 37.4 4.4 2.1e-06 26.0 0.7 2.1 2 0 0 2 2 2 2 Prominin Tweety PF04906.13 ETO09635.1 - 0.013 14.2 0.1 0.013 14.2 0.1 2.2 1 1 0 2 2 2 0 Tweety WXG100 PF06013.12 ETO09635.1 - 0.053 13.8 0.2 0.67 10.2 0.1 2.6 2 1 1 3 3 3 0 Proteins of 100 residues with WXG DUF948 PF06103.11 ETO09635.1 - 0.097 12.9 0.3 0.097 12.9 0.3 2.9 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TMEM154 PF15102.6 ETO09635.1 - 1 9.3 3.6 1.2 9.0 1.1 2.3 2 1 0 2 2 2 0 TMEM154 protein family DUF3671 PF12420.8 ETO09635.1 - 1.7 8.8 5.8 2 8.5 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function JAKMIP_CC3 PF16034.5 ETO09637.1 - 0.00059 19.8 0.9 0.00099 19.1 0.9 1.3 1 0 0 1 1 1 1 JAKMIP CC3 domain DUF2353 PF09789.9 ETO09637.1 - 0.00099 18.6 1.5 0.0014 18.0 1.5 1.2 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) FapA PF03961.13 ETO09637.1 - 0.0033 16.1 4.0 0.0045 15.7 4.0 1.1 1 0 0 1 1 1 1 Flagellar Assembly Protein A Laminin_II PF06009.12 ETO09637.1 - 0.0051 16.8 1.1 0.0091 16.0 1.1 1.4 1 0 0 1 1 1 1 Laminin Domain II MscS_porin PF12795.7 ETO09637.1 - 0.031 13.8 1.0 0.053 13.1 1.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Inv-AAD PF18785.1 ETO09637.1 - 0.072 13.0 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Invertebrate-AID/APOBEC-deaminase TMF_TATA_bd PF12325.8 ETO09637.1 - 0.12 12.5 4.6 0.37 11.0 2.0 2.3 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding PRKG1_interact PF15898.5 ETO09637.1 - 0.31 11.9 4.1 0.69 10.9 4.1 1.7 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 ETO09637.1 - 2.6 7.9 10.3 7 6.5 2.5 3.0 2 1 1 3 3 3 0 Septum formation initiator MIEAP PF16026.5 ETO09638.1 - 0.024 14.8 0.5 0.054 13.7 0.0 1.8 2 0 0 2 2 2 0 Mitochondria-eating protein LicD PF04991.13 ETO09638.1 - 0.071 13.2 3.3 0.12 12.5 3.3 1.3 1 0 0 1 1 1 0 LicD family BcrAD_BadFG PF01869.20 ETO09639.1 - 0.26 10.7 0.0 0.35 10.3 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family HSP70 PF00012.20 ETO09640.1 - 0.0013 17.1 0.1 0.0016 16.7 0.1 1.2 1 0 0 1 1 1 1 Hsp70 protein DDR PF08841.10 ETO09640.1 - 0.15 11.0 0.1 0.23 10.4 0.1 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain CLN6 PF15156.6 ETO09641.1 - 0.097 11.9 0.0 0.25 10.6 0.0 1.6 1 1 1 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 6 HSP70 PF00012.20 ETO09642.1 - 0.00043 18.6 0.0 0.0011 17.2 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein VWA_2 PF13519.6 ETO09642.1 - 0.013 16.1 0.0 0.039 14.6 0.0 1.8 1 0 0 1 1 1 0 von Willebrand factor type A domain Cyclin_N PF00134.23 ETO09643.1 - 1.2e-06 28.3 0.3 1.9e-06 27.6 0.3 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain ADH_zinc_N PF00107.26 ETO09644.1 - 2.2e-19 69.7 0.0 4.1e-19 68.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO09644.1 - 6.5e-14 53.1 0.0 4.7e-13 50.3 0.0 2.1 2 0 0 2 2 2 1 Zinc-binding dehydrogenase FGGY_C PF02782.16 ETO09644.1 - 0.007 16.1 0.0 0.013 15.3 0.0 1.4 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain ETX_MTX2 PF03318.13 ETO09645.1 - 0.039 13.7 12.5 0.058 13.2 12.5 1.2 1 0 0 1 1 1 0 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2 Trypan_PARP PF05887.11 ETO09645.1 - 0.18 11.8 0.4 0.37 10.8 0.4 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF2170 PF09938.9 ETO09646.1 - 0.01 15.5 0.4 0.017 14.9 0.4 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2170) EF-hand_1 PF00036.32 ETO09647.1 - 1.4e-24 83.8 9.9 1.8e-06 27.1 0.0 5.6 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETO09647.1 - 2.6e-23 82.2 16.8 2.3e-11 43.9 1.2 3.7 4 1 1 5 5 5 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO09647.1 - 4.4e-19 66.7 14.4 0.00014 21.5 0.1 6.0 6 0 0 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 ETO09647.1 - 5.4e-15 54.1 12.8 3.2e-05 23.2 0.1 5.0 5 0 0 5 5 5 3 EF hand Pkinase PF00069.25 ETO09647.1 - 7.4e-15 55.0 0.0 1.7e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain EF-hand_8 PF13833.6 ETO09647.1 - 1e-10 41.3 6.7 9.5e-05 22.2 1.1 3.2 2 2 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO09647.1 - 7e-05 23.1 6.8 0.039 14.3 0.1 2.9 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO09647.1 - 0.0033 17.3 3.7 0.68 9.9 0.2 2.8 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand Pkinase_Tyr PF07714.17 ETO09647.1 - 0.055 12.7 0.0 0.12 11.6 0.0 1.6 1 1 0 1 1 1 0 Protein tyrosine kinase EF-hand_11 PF08976.11 ETO09647.1 - 0.079 13.8 0.2 0.63 10.9 0.1 2.5 1 1 1 2 2 2 0 EF-hand domain His_Phos_1 PF00300.22 ETO09648.1 - 2.4e-05 24.1 2.1 0.00031 20.5 0.0 2.7 3 1 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) POX PF07526.11 ETO09648.1 - 0.13 12.8 5.9 0.3 11.6 5.9 1.6 1 0 0 1 1 1 0 Associated with HOX ALMT PF11744.8 ETO09648.1 - 1.5 7.6 13.8 2.3 7.0 13.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Sporozoite_P67 PF05642.11 ETO09648.1 - 2.4 6.1 5.1 3.2 5.7 5.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4770 PF15994.5 ETO09648.1 - 2.5 8.3 10.1 21 5.3 6.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) PI3K_1B_p101 PF10486.9 ETO09648.1 - 2.8 5.6 11.9 4.5 4.9 11.9 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Presenilin PF01080.17 ETO09648.1 - 7.9 5.1 8.9 12 4.5 8.9 1.2 1 0 0 1 1 1 0 Presenilin uDENN PF03456.18 ETO09649.1 - 0.00056 20.6 0.1 0.0011 19.7 0.1 1.7 1 1 0 1 1 1 1 uDENN domain DENN PF02141.21 ETO09650.1 - 2e-39 135.5 8.7 3.8e-39 134.6 8.7 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain RuvB_N PF05496.12 ETO09650.1 - 0.0024 17.6 0.5 0.0042 16.8 0.5 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ENTH PF01417.20 ETO09650.1 - 0.044 13.8 0.0 0.14 12.2 0.0 1.8 1 0 0 1 1 1 0 ENTH domain Avl9 PF09794.9 ETO09650.1 - 0.7 8.5 5.3 0.8 8.3 1.3 2.5 2 1 1 3 3 3 0 Transport protein Avl9 Mucin PF01456.17 ETO09650.1 - 3 7.8 42.8 1.9 8.5 38.0 2.7 2 0 0 2 2 2 0 Mucin-like glycoprotein Metallophos PF00149.28 ETO09651.1 - 2.5e-08 34.7 5.2 6.4e-06 26.8 5.2 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase MCD PF05292.11 ETO09651.1 - 0.016 14.8 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 Malonyl-CoA decarboxylase C-terminal domain LIM PF00412.22 ETO09652.1 - 0.0078 16.4 4.5 0.0078 16.4 4.5 4.3 4 1 0 4 4 4 2 LIM domain ATG16 PF08614.11 ETO09652.1 - 0.0082 16.4 2.4 0.0082 16.4 2.4 2.1 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 ETO09652.1 - 0.02 15.0 8.8 1.5 9.0 0.1 3.5 3 0 0 3 3 3 0 bZIP transcription factor Spidroin_N PF16763.5 ETO09652.1 - 0.049 13.6 1.3 0.1 12.6 1.3 1.5 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term APG6_N PF17675.1 ETO09652.1 - 0.068 13.7 8.7 5.4 7.6 4.9 2.7 2 0 0 2 2 2 0 Apg6 coiled-coil region Cytokin-bind PF09265.10 ETO09652.1 - 0.074 12.4 0.4 1.4 8.2 0.0 2.3 2 0 0 2 2 2 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding DUF4530 PF15039.6 ETO09652.1 - 0.11 12.6 3.3 1.6 8.9 1.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4530) DUF2935 PF11155.8 ETO09652.1 - 0.12 12.7 1.0 3.9 7.8 1.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DUF1364 PF07102.12 ETO09652.1 - 0.18 11.7 5.1 38 4.2 0.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1364) ZapB PF06005.12 ETO09652.1 - 0.2 12.1 16.2 0.22 12.0 2.7 3.3 2 1 1 3 3 3 0 Cell division protein ZapB DivIC PF04977.15 ETO09652.1 - 0.88 9.4 12.0 21 5.0 0.1 3.5 3 0 0 3 3 3 0 Septum formation initiator Uds1 PF15456.6 ETO09652.1 - 1.1 9.4 6.4 0.8 9.9 2.6 2.4 2 0 0 2 2 2 0 Up-regulated During Septation DUF4407 PF14362.6 ETO09652.1 - 1.1 8.5 8.8 2 7.7 8.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 ETO09652.1 - 1.3 7.5 7.6 0.28 9.7 4.0 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A bZIP_2 PF07716.15 ETO09652.1 - 1.8 8.7 15.7 7.4 6.7 3.5 3.4 3 0 0 3 3 3 0 Basic region leucine zipper Cep57_CLD_2 PF14197.6 ETO09652.1 - 2.9 8.1 9.5 3.6 7.7 0.7 3.1 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Tropomyosin_1 PF12718.7 ETO09652.1 - 6.7 6.9 17.4 1.5 8.9 4.9 3.2 2 1 1 3 3 3 0 Tropomyosin like SWIRM-assoc_2 PF16496.5 ETO09653.1 - 1.2e-14 54.1 0.0 1.4e-14 53.8 0.0 1.1 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal BRCT_2 PF16589.5 ETO09653.1 - 0.011 16.1 0.0 0.019 15.4 0.0 1.4 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain STAT_int PF02865.17 ETO09653.1 - 0.036 14.5 0.0 2.6 8.5 0.0 2.1 1 1 1 2 2 2 0 STAT protein, protein interaction domain SWIRM PF04433.17 ETO09654.1 - 6.1e-19 68.2 0.5 5e-18 65.2 0.5 2.6 1 1 0 1 1 1 1 SWIRM domain GREB1 PF15782.5 ETO09654.1 - 0.24 8.5 18.9 0.34 8.0 18.9 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CAC1F_C PF16885.5 ETO09654.1 - 3.1 7.4 19.5 0.73 9.4 16.2 1.7 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term Menin PF05053.13 ETO09654.1 - 7.3 4.8 21.8 2 6.7 18.8 1.6 2 0 0 2 2 2 0 Menin SWIRM-assoc_1 PF16495.5 ETO09655.1 - 6e-12 45.4 5.4 6e-12 45.4 5.4 1.9 2 0 0 2 2 2 1 SWIRM-associated region 1 Tox-MPTase2 PF15638.6 ETO09655.1 - 0.083 12.6 0.7 0.38 10.5 0.3 2.1 1 1 0 1 1 1 0 Metallopeptidase toxin 2 KfrA_N PF11740.8 ETO09655.1 - 0.1 13.3 5.6 0.72 10.5 3.9 2.7 3 0 0 3 3 3 0 Plasmid replication region DNA-binding N-term Exonuc_VII_L PF02601.15 ETO09655.1 - 0.11 12.0 1.8 0.18 11.3 1.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit ubiquitin PF00240.23 ETO09656.1 - 3.9e-07 29.7 0.0 9e-07 28.6 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO09656.1 - 0.00059 19.6 0.0 0.0016 18.3 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF468 PF04318.12 ETO09658.1 - 0.002 18.8 0.2 0.004 17.8 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF468) ECSIT PF06239.11 ETO09658.1 - 0.022 13.9 1.2 0.032 13.3 1.2 1.2 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway POPLD PF08170.12 ETO09658.1 - 0.081 13.3 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 POPLD (NUC188) domain SAM_1 PF00536.30 ETO09659.1 - 0.00078 19.8 0.2 0.12 12.8 0.1 3.1 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) MukB_hinge PF16330.5 ETO09659.1 - 0.0036 17.0 0.0 0.0074 16.0 0.0 1.5 1 0 0 1 1 1 1 MukB hinge domain SAM_2 PF07647.17 ETO09659.1 - 0.0085 16.2 2.5 4.2 7.5 0.3 3.5 3 1 0 3 3 3 2 SAM domain (Sterile alpha motif) Menin PF05053.13 ETO09659.1 - 0.84 7.9 8.3 1.2 7.4 8.3 1.2 1 0 0 1 1 1 0 Menin zf-C2H2_2 PF12756.7 ETO09660.1 - 1.9e-21 76.3 0.5 1.9e-21 76.3 0.5 2.5 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) FAM176 PF14851.6 ETO09660.1 - 0.88 9.2 6.3 0.4 10.3 2.0 2.6 3 0 0 3 3 3 0 FAM176 family zf-C2H2 PF00096.26 ETO09660.1 - 1.7 9.2 10.6 1.7 9.3 2.3 3.1 2 0 0 2 2 2 0 Zinc finger, C2H2 type GspH PF12019.8 ETO09661.1 - 0.056 13.9 0.5 0.075 13.5 0.5 1.1 1 0 0 1 1 1 0 Type II transport protein GspH DUF3439 PF11921.8 ETO09661.1 - 0.075 13.0 0.6 0.081 12.9 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO09661.1 - 0.24 9.4 2.5 0.23 9.4 2.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SPRY PF00622.28 ETO09662.1 - 0.00057 20.0 0.4 0.0026 17.9 0.3 2.0 1 1 1 2 2 2 1 SPRY domain Ribosomal_S28e PF01200.18 ETO09662.1 - 0.18 11.8 0.0 0.35 10.9 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S28e DEAD PF00270.29 ETO09664.1 - 1.2e-17 64.2 0.0 2.8e-17 63.0 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO09664.1 - 8.4e-14 51.9 1.3 1.8e-11 44.3 0.1 3.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO09664.1 - 1.3e-06 28.5 0.0 1.3e-06 28.5 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF3439 PF11921.8 ETO09664.1 - 0.027 14.4 5.9 0.082 12.9 5.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Myc_N PF01056.18 ETO09664.1 - 0.087 12.7 8.2 0.75 9.6 0.4 2.5 2 0 0 2 2 2 0 Myc amino-terminal region HHH_5 PF14520.6 ETO09664.1 - 0.094 13.3 0.1 10 6.8 0.0 2.7 3 0 0 3 3 3 0 Helix-hairpin-helix domain DUF3682 PF12446.8 ETO09664.1 - 1.2 9.7 16.0 0.45 11.0 1.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Med8 PF10232.9 ETO09664.1 - 2 7.9 6.8 3 7.4 0.8 2.5 2 0 0 2 2 2 0 Mediator of RNA polymerase II transcription complex subunit 8 SSP160 PF06933.11 ETO09664.1 - 4.2 5.4 9.0 9.5 4.3 9.0 1.5 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dynamin_N PF00350.23 ETO09664.1 - 8.8 6.3 8.7 18 5.4 1.8 3.1 2 1 1 3 3 3 0 Dynamin family PLA2G12 PF06951.11 ETO09666.1 - 1.5e-12 47.8 17.6 7.8e-12 45.5 17.6 1.9 1 1 0 1 1 1 1 Group XII secretory phospholipase A2 precursor (PLA2G12) DnaJ PF00226.31 ETO09667.1 - 8.3e-13 48.3 0.1 2.3e-12 46.8 0.1 1.8 1 0 0 1 1 1 1 DnaJ domain PRAI PF00697.22 ETO09667.1 - 0.078 12.7 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Raftlin PF15250.6 ETO09667.1 - 0.21 10.3 7.4 0.25 10.1 7.4 1.0 1 0 0 1 1 1 0 Raftlin DUF3807 PF12720.7 ETO09667.1 - 0.26 11.6 10.5 0.36 11.1 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Menin PF05053.13 ETO09667.1 - 0.48 8.7 7.1 0.51 8.6 7.1 1.0 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 ETO09667.1 - 0.6 8.3 10.9 0.65 8.2 10.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 ETO09667.1 - 1.5 9.3 8.2 2.2 8.8 8.2 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Gti1_Pac2 PF09729.9 ETO09667.1 - 1.6 8.8 9.5 1.9 8.5 9.5 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family DNA_pol_delta_4 PF04081.13 ETO09667.1 - 1.9 8.8 11.0 3.9 7.8 11.0 1.6 1 1 0 1 1 1 0 DNA polymerase delta, subunit 4 Membralin PF09746.9 ETO09667.1 - 2.1 7.3 5.5 2.6 7.0 5.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO09667.1 - 2.6 6.7 9.0 2.7 6.7 9.0 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO09667.1 - 2.7 6.7 9.9 3 6.6 9.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 ETO09667.1 - 4.4 7.3 5.3 4.9 7.1 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LIM PF00412.22 ETO09668.1 - 5.5e-06 26.5 6.2 1.1e-05 25.6 6.2 1.5 1 0 0 1 1 1 1 LIM domain Sa_NUDIX PF18167.1 ETO09668.1 - 0.0019 18.0 0.2 0.0027 17.5 0.2 1.2 1 0 0 1 1 1 1 SMODS-associated NUDIX domain Zn-ribbon_8 PF09723.10 ETO09668.1 - 1.8 8.8 5.8 0.71 10.0 2.4 2.1 2 0 0 2 2 2 0 Zinc ribbon domain Got1 PF04178.12 ETO09668.1 - 7.6 7.0 10.3 48 4.4 10.5 2.0 1 1 0 1 1 1 0 Got1/Sft2-like family Ribosomal_L27 PF01016.19 ETO09670.1 - 5.1e-20 71.3 0.6 9.4e-20 70.4 0.6 1.4 1 0 0 1 1 1 1 Ribosomal L27 protein DUF2325 PF10087.9 ETO09670.1 - 0.2 11.8 1.9 0.4 10.8 0.6 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2325) 2OG-FeII_Oxy_3 PF13640.6 ETO09671.1 - 6.1e-09 36.7 0.0 1.5e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_2 PF13532.6 ETO09671.1 - 0.0093 16.2 0.0 0.018 15.2 0.0 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Asp_Arg_Hydrox PF05118.15 ETO09671.1 - 0.033 14.0 0.7 0.11 12.3 0.1 2.1 2 1 0 2 2 2 0 Aspartyl/Asparaginyl beta-hydroxylase 2OG-FeII_Oxy_4 PF13661.6 ETO09671.1 - 0.049 14.3 0.2 0.17 12.6 0.0 2.0 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily REJ PF02010.15 ETO09673.1 - 1.5e-11 43.8 0.9 2.8e-11 42.9 0.9 1.5 1 0 0 1 1 1 1 REJ domain GPS PF01825.21 ETO09673.1 - 2.3e-05 24.8 7.6 0.00036 21.0 7.6 2.8 1 1 0 1 1 1 1 GPCR proteolysis site, GPS, motif Cytomega_TRL10 PF06084.11 ETO09673.1 - 0.14 12.2 2.2 0.14 12.2 0.0 2.1 3 0 0 3 3 3 0 Cytomegalovirus TRL10 protein Myotub-related PF06602.14 ETO09674.1 - 7.6e-72 242.2 4.7 3.6e-60 203.7 1.8 2.3 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain FYVE PF01363.21 ETO09674.1 - 4.2e-09 36.4 10.5 1.1e-08 35.1 10.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger Y_phosphatase PF00102.27 ETO09674.1 - 0.019 14.5 0.1 0.045 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ETO09674.1 - 0.04 13.9 0.0 0.072 13.0 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family IBR PF01485.21 ETO09674.1 - 0.055 13.7 5.8 0.21 11.9 5.8 2.0 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF3439 PF11921.8 ETO09675.1 - 0.0044 17.0 3.6 0.019 14.9 3.6 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) CSD PF00313.22 ETO09675.1 - 0.0049 16.7 0.3 1.3 8.9 0.0 3.4 4 0 0 4 4 4 2 'Cold-shock' DNA-binding domain ArfGap PF01412.18 ETO09676.1 - 0.022 14.8 0.2 0.06 13.4 0.2 1.7 1 0 0 1 1 1 0 Putative GTPase activating protein for Arf ShK PF01549.24 ETO09677.1 - 0.00019 21.9 7.0 0.00019 21.9 4.4 2.3 2 0 0 2 2 2 1 ShK domain-like PAN_4 PF14295.6 ETO09677.1 - 0.025 14.5 0.1 0.025 14.5 0.1 2.2 2 0 0 2 2 2 0 PAN domain Crisp PF08562.10 ETO09677.1 - 7.4 7.2 11.1 22 5.7 0.2 2.8 3 0 0 3 3 3 0 Crisp SNF2_N PF00176.23 ETO09679.1 - 1.7e-22 79.7 0.0 4.2e-21 75.1 0.0 2.7 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO09679.1 - 0.026 14.5 0.0 0.54 10.2 0.0 2.7 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit EMC1_C PF07774.13 ETO09679.1 - 0.063 13.0 0.6 0.11 12.1 0.6 1.4 1 0 0 1 1 1 0 ER membrane protein complex subunit 1, C-terminal PDZ_6 PF17820.1 ETO09681.1 - 0.0016 18.3 0.0 0.0023 17.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain SP_C-Propep PF08999.10 ETO09682.1 - 0.054 13.3 0.2 0.08 12.7 0.2 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Brix PF04427.18 ETO09683.1 - 0.0006 20.0 0.7 0.0022 18.1 0.2 1.9 2 0 0 2 2 2 1 Brix domain DUF188 PF02639.14 ETO09683.1 - 0.013 15.1 1.1 1.6 8.4 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Lipase_GDSL_3 PF14606.6 ETO09683.1 - 0.16 12.1 0.8 0.23 11.5 0.8 1.4 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family 2OG-FeII_Oxy_3 PF13640.6 ETO09684.1 - 1.6e-06 28.9 0.0 3.4e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily IBB PF01749.20 ETO09684.1 - 0.00015 22.2 6.5 0.00015 22.2 6.5 1.9 2 0 0 2 2 2 1 Importin beta binding domain Mustang PF15682.5 ETO09684.1 - 0.48 10.5 3.0 0.23 11.6 0.6 1.7 2 0 0 2 2 2 0 Musculoskeletal, temporally activated-embryonic nuclear protein 1 FANCI_S3 PF14677.6 ETO09685.1 - 0.0086 15.8 4.0 0.012 15.4 1.1 2.0 1 1 1 2 2 2 1 FANCI solenoid 3 GKAP PF03359.13 ETO09685.1 - 0.069 12.7 0.0 0.09 12.3 0.0 1.2 1 0 0 1 1 1 0 Guanylate-kinase-associated protein (GKAP) protein RNA_pol_Rpb1_3 PF04983.18 ETO09685.1 - 0.11 12.5 0.1 0.22 11.4 0.1 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 3 PPR_3 PF13812.6 ETO09688.1 - 0.13 12.3 0.2 0.29 11.2 0.1 1.6 2 0 0 2 2 2 0 Pentatricopeptide repeat domain Aldose_epim PF01263.20 ETO09689.1 - 1.7e-28 99.8 0.4 2.6e-28 99.2 0.4 1.1 1 0 0 1 1 1 1 Aldose 1-epimerase GPI2 PF06432.11 ETO09690.1 - 0.074 12.5 2.3 0.13 11.7 2.3 1.4 1 0 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase Mak10 PF04112.13 ETO09690.1 - 0.22 11.0 0.9 0.41 10.1 0.9 1.5 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase DUF1319 PF07028.11 ETO09692.1 - 0.18 12.0 0.8 0.36 11.1 0.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1319) TPR_1 PF00515.28 ETO09693.1 - 2.1e-09 36.8 2.8 0.0015 18.3 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09693.1 - 3.5e-09 36.1 1.1 0.015 15.4 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.8 ETO09693.1 - 2.3e-05 23.5 0.4 3.5e-05 22.9 0.4 1.3 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 TPR_8 PF13181.6 ETO09693.1 - 2.5e-05 24.1 5.0 0.025 14.8 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO09693.1 - 0.00049 20.7 0.0 0.61 10.8 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09693.1 - 0.00072 19.4 0.0 0.78 9.9 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09693.1 - 0.0016 18.1 0.5 0.045 13.4 0.0 2.5 2 0 0 2 2 2 1 TPR repeat ANAPC3 PF12895.7 ETO09693.1 - 0.0024 18.1 2.8 0.0048 17.1 2.8 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ETO09693.1 - 0.0083 16.4 0.9 0.093 13.0 0.3 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO09693.1 - 0.014 16.0 0.1 4.5 8.1 0.2 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO09693.1 - 0.02 14.9 0.5 0.078 13.1 0.5 2.1 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat CDC45 PF02724.14 ETO09694.1 - 0.68 8.2 8.8 0.7 8.1 8.8 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO09694.1 - 9.7 5.5 18.3 10 5.4 18.3 1.1 1 0 0 1 1 1 0 SDA1 SUIM_assoc PF16619.5 ETO09695.1 - 0.36 10.9 8.4 0.58 10.3 8.4 1.5 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 zf-Di19 PF05605.12 ETO09696.1 - 0.00043 20.5 10.5 0.00043 20.5 10.5 2.5 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.17 ETO09696.1 - 0.03 14.2 0.9 0.03 14.2 0.9 3.1 3 0 0 3 3 3 0 Zinc finger, ZZ type U-box PF04564.15 ETO09697.1 - 7.8e-23 80.4 0.8 2.1e-22 79.1 0.8 1.8 1 0 0 1 1 1 1 U-box domain LptE PF04390.12 ETO09697.1 - 0.046 14.4 2.6 0.74 10.5 0.4 2.5 2 0 0 2 2 2 0 Lipopolysaccharide-assembly Pkinase PF00069.25 ETO09700.1 - 2e-27 96.2 0.0 3.4e-26 92.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09700.1 - 1.2e-12 47.6 0.0 9e-07 28.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DUF2894 PF11445.8 ETO09701.1 - 0.046 14.2 0.9 0.18 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2894) DUF1682 PF07946.14 ETO09701.1 - 0.099 11.8 4.2 0.28 10.3 4.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Peptidase_S49_N PF08496.10 ETO09701.1 - 0.6 10.2 5.6 4.3 7.4 5.9 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Smim3 PF17307.2 ETO09702.1 - 0.0018 17.7 0.2 0.0018 17.7 0.2 2.7 3 0 0 3 3 3 1 Small integral membrane protein 3 DUF4598 PF15370.6 ETO09702.1 - 0.14 12.7 1.7 0.22 12.0 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) FAM176 PF14851.6 ETO09702.1 - 0.24 11.0 0.0 0.24 11.0 0.0 2.2 3 0 0 3 3 3 0 FAM176 family BIRC6 PF12356.8 ETO09702.1 - 1.2 8.6 3.0 23 4.4 3.2 2.2 1 1 1 2 2 2 0 Baculoviral IAP repeat-containing protein 6 DUF4064 PF13273.6 ETO09702.1 - 4.3 7.7 6.7 3.3 8.1 0.3 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) DUF3490 PF11995.8 ETO09704.1 - 3.8e-06 26.8 0.5 3.8e-06 26.8 0.5 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3490) IQ PF00612.27 ETO09704.1 - 0.034 13.9 3.2 2.5 8.2 0.0 4.0 4 0 0 4 4 4 0 IQ calmodulin-binding motif LMF1 PF06762.14 ETO09705.1 - 3.9e-41 141.6 31.4 9.6e-19 67.8 14.7 4.2 3 1 0 3 3 3 3 Lipase maturation factor TMEM208_SND2 PF05620.11 ETO09705.1 - 0.021 14.6 0.8 0.021 14.6 0.8 2.7 4 0 0 4 4 4 0 SRP-independent targeting protein 2/TMEM208 SpoVAB PF13782.6 ETO09705.1 - 0.022 15.0 1.1 0.079 13.3 0.3 2.2 2 0 0 2 2 2 0 Stage V sporulation protein AB DUF4834 PF16118.5 ETO09705.1 - 0.051 14.5 7.7 0.13 13.2 0.2 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) RskA PF10099.9 ETO09705.1 - 0.11 12.8 0.0 0.59 10.4 0.1 1.9 2 0 0 2 2 2 0 Anti-sigma-K factor rskA DUF4770 PF15994.5 ETO09705.1 - 0.19 12.0 6.2 1.6 9.0 1.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) LMF1 PF06762.14 ETO09706.1 - 6.7e-06 25.5 0.1 1.3e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Lipase maturation factor Linker_histone PF00538.19 ETO09708.1 - 2.9e-08 34.0 0.1 2.9e-08 34.0 0.1 2.4 2 0 0 2 2 2 1 linker histone H1 and H5 family ATE_C PF04377.15 ETO09708.1 - 0.0075 16.9 0.8 0.015 15.9 0.1 1.8 2 0 0 2 2 2 1 Arginine-tRNA-protein transferase, C terminus DUF5613 PF18467.1 ETO09708.1 - 0.55 10.7 6.7 0.12 12.8 1.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF5613) Put_Phosphatase PF06888.12 ETO09709.1 - 0.0004 19.9 0.0 0.0005 19.5 0.0 1.1 1 0 0 1 1 1 1 Putative Phosphatase DUF2812 PF11193.8 ETO09709.1 - 0.033 14.4 1.3 0.043 14.0 0.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2812) Put_Phosphatase PF06888.12 ETO09710.1 - 8.2e-25 87.6 2.0 4.1e-22 78.7 2.0 2.8 1 1 0 1 1 1 1 Putative Phosphatase HAD PF12710.7 ETO09710.1 - 0.053 13.9 0.1 0.94 9.8 0.1 2.2 1 1 1 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1325 PF07039.11 ETO09711.1 - 1.1e-16 61.1 0.1 2e-16 60.3 0.1 1.4 1 0 0 1 1 1 1 SGF29 tudor-like domain Tudor_3 PF18115.1 ETO09711.1 - 1.5e-05 24.8 0.1 3.3e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4537 PF15057.6 ETO09711.1 - 7.3e-05 22.8 0.1 0.0038 17.2 0.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4537) TUDOR_5 PF18359.1 ETO09711.1 - 0.00013 21.6 0.1 0.0012 18.5 0.0 2.2 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain 1 DUF2039 PF10217.9 ETO09712.1 - 0.14 12.6 0.4 0.14 12.6 0.4 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2039) ETRAMP PF09716.10 ETO09712.1 - 0.27 11.3 4.1 0.23 11.6 2.7 1.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Aa_trans PF01490.18 ETO09713.1 - 3.1e-57 194.1 24.4 4.4e-57 193.6 24.4 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein NDUF_B12 PF08122.12 ETO09713.1 - 1.3 9.1 5.6 0.73 9.9 0.1 3.4 4 0 0 4 4 4 0 NADH-ubiquinone oxidoreductase B12 subunit family DUF2451 PF10474.9 ETO09714.1 - 3e-15 56.7 3.8 5.4e-15 55.8 1.0 2.5 2 0 0 2 2 2 1 Protein of unknown function C-terminus (DUF2451) Vps54_N PF10475.9 ETO09714.1 - 2e-10 40.4 6.7 2e-10 40.4 6.7 1.7 2 0 0 2 2 2 1 Vacuolar-sorting protein 54, of GARP complex DUF3510 PF12022.8 ETO09714.1 - 0.35 11.3 0.1 0.35 11.3 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF3510) SOBP PF15279.6 ETO09714.1 - 6.5 7.3 11.8 11 6.5 11.8 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein WH1 PF00568.23 ETO09715.1 - 0.0027 17.6 0.1 0.0057 16.6 0.1 1.6 1 0 0 1 1 1 1 WH1 domain HABP4_PAI-RBP1 PF04774.15 ETO09716.1 - 1.9e-13 51.2 7.8 1.9e-13 51.2 7.8 2.9 2 1 1 3 3 3 1 Hyaluronan / mRNA binding family RHH_6 PF16762.5 ETO09716.1 - 0.11 13.1 0.1 0.37 11.4 0.1 1.9 2 0 0 2 2 2 0 Ribbon-helix-helix domain Merozoite_SPAM PF07133.11 ETO09716.1 - 0.23 11.4 6.5 0.39 10.7 6.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Macoilin PF09726.9 ETO09717.1 - 0.011 14.3 27.7 0.015 13.9 27.7 1.1 1 0 0 1 1 1 0 Macoilin family BUD22 PF09073.10 ETO09717.1 - 0.026 13.9 26.1 0.051 12.9 26.1 1.4 1 0 0 1 1 1 0 BUD22 MMPL PF03176.15 ETO09718.1 - 5.2e-14 51.9 0.0 2.4e-13 49.8 0.0 1.7 1 1 0 1 1 1 1 MMPL family RP853 PF17542.2 ETO09718.1 - 0.067 12.3 0.3 0.1 11.7 0.3 1.2 1 0 0 1 1 1 0 Uncharacterized RP853 SAC3_GANP PF03399.16 ETO09719.1 - 6.1e-08 32.4 0.8 5.9e-06 25.9 0.8 2.3 1 1 0 1 1 1 1 SAC3/GANP family DUF728 PF05304.12 ETO09719.1 - 4.9 7.0 7.0 4.7 7.0 0.1 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF728) Piwi PF02171.17 ETO09720.1 - 2.7e-11 43.3 0.0 8.2e-11 41.7 0.0 1.7 1 1 0 1 1 1 1 Piwi domain Helo_like_N PF17111.5 ETO09720.1 - 0.06 12.7 1.7 0.13 11.6 1.7 1.5 1 0 0 1 1 1 0 Fungal N-terminal domain of STAND proteins ICMT PF04140.14 ETO09721.1 - 7.6e-13 48.7 0.4 1e-12 48.3 0.4 1.2 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO09721.1 - 1e-12 48.3 0.1 1.5e-12 47.9 0.1 1.2 1 0 0 1 1 1 1 Phospholipid methyltransferase DUF1295 PF06966.12 ETO09721.1 - 0.036 13.6 0.1 0.05 13.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1295) ERG4_ERG24 PF01222.17 ETO09721.1 - 0.041 12.7 0.3 0.047 12.5 0.3 1.1 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family F-box-like PF12937.7 ETO09723.1 - 0.23 11.4 5.8 0.27 11.1 1.3 2.6 2 0 0 2 2 2 0 F-box-like Amino_oxidase PF01593.24 ETO09724.1 - 1.1e-31 110.7 0.0 1.2e-15 57.7 0.0 2.4 2 1 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETO09724.1 - 6.6e-14 51.9 0.1 2e-12 47.2 0.0 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETO09724.1 - 2.4e-07 30.7 0.0 3.8e-07 30.0 0.0 1.4 1 1 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ETO09724.1 - 5e-05 22.8 0.1 0.00011 21.7 0.0 1.6 2 0 0 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETO09724.1 - 7.6e-05 22.1 0.0 0.00014 21.2 0.0 1.4 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ETO09724.1 - 0.00022 20.0 0.7 0.00055 18.8 0.0 2.0 2 0 0 2 2 2 1 HI0933-like protein Pyr_redox_2 PF07992.14 ETO09724.1 - 0.00082 18.7 0.2 0.0033 16.7 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETO09724.1 - 0.0012 18.2 2.8 0.0032 16.8 0.3 2.1 2 0 0 2 2 2 1 FAD binding domain MCRA PF06100.11 ETO09724.1 - 0.0083 15.0 0.6 0.012 14.4 0.0 1.5 2 0 0 2 2 2 1 MCRA family NAD_binding_9 PF13454.6 ETO09724.1 - 0.01 15.9 0.0 0.026 14.5 0.0 1.8 1 0 0 1 1 1 0 FAD-NAD(P)-binding FAD_binding_2 PF00890.24 ETO09724.1 - 0.018 14.2 0.3 0.027 13.6 0.3 1.2 1 0 0 1 1 1 0 FAD binding domain Trp_halogenase PF04820.14 ETO09724.1 - 0.027 13.3 0.1 0.043 12.7 0.1 1.3 1 0 0 1 1 1 0 Tryptophan halogenase Pyr_redox PF00070.27 ETO09724.1 - 0.039 14.5 0.3 0.14 12.7 0.3 2.0 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ETO09724.1 - 0.04 13.2 0.1 0.081 12.2 0.1 1.4 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ETO09724.1 - 0.15 11.1 0.0 0.22 10.5 0.0 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein MPP6 PF10175.9 ETO09724.1 - 1.6 9.2 10.0 2.1 8.8 3.7 2.5 2 0 0 2 2 2 0 M-phase phosphoprotein 6 DUF5320 PF17253.2 ETO09725.1 - 0.015 16.3 23.8 0.024 15.7 22.9 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5320) ABC_tran PF00005.27 ETO09726.1 - 4.2e-14 53.2 0.0 4.2e-14 53.2 0.0 3.0 2 2 0 2 2 2 1 ABC transporter ABC_membrane PF00664.23 ETO09726.1 - 7.8e-11 42.1 0.5 7.8e-11 42.1 0.5 3.0 2 1 1 3 3 3 1 ABC transporter transmembrane region Mucin PF01456.17 ETO09726.1 - 0.0001 22.3 4.8 0.0001 22.3 4.8 2.3 2 0 0 2 2 2 1 Mucin-like glycoprotein Dynamin_N PF00350.23 ETO09726.1 - 0.0094 16.0 0.1 0.0094 16.0 0.1 3.1 3 1 0 3 3 3 1 Dynamin family AAA_29 PF13555.6 ETO09726.1 - 0.041 13.6 0.4 0.098 12.4 0.4 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain IQCJ-SCHIP1 PF15157.6 ETO09726.1 - 0.041 13.7 4.6 0.089 12.6 2.1 2.4 2 0 0 2 2 2 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif MMR_HSR1 PF01926.23 ETO09726.1 - 0.079 13.0 0.1 0.079 13.0 0.1 2.6 2 0 0 2 2 2 0 50S ribosome-binding GTPase NESP55 PF06390.12 ETO09726.1 - 0.17 11.5 5.8 0.33 10.5 5.8 1.4 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) SMC_N PF02463.19 ETO09726.1 - 0.52 9.7 10.8 0.18 11.2 0.2 3.1 2 1 0 3 3 3 0 RecF/RecN/SMC N terminal domain Atrophin-1 PF03154.15 ETO09726.1 - 4.5 5.4 14.9 0.4 8.9 1.7 2.2 2 0 0 2 2 2 0 Atrophin-1 family MMADHC PF10229.9 ETO09728.1 - 2.9e-14 53.5 0.8 7.2e-09 35.8 0.0 2.2 2 0 0 2 2 2 2 Methylmalonic aciduria and homocystinuria type D protein MRAP PF15183.6 ETO09728.1 - 0.0041 17.0 0.1 0.0041 17.0 0.1 2.4 2 0 0 2 2 2 1 Melanocortin-2 receptor accessory protein family TraN PF06986.11 ETO09728.1 - 0.0059 16.3 1.5 0.01 15.6 1.5 1.3 1 0 0 1 1 1 1 Type-1V conjugative transfer system mating pair stabilisation GT87 PF09594.10 ETO09728.1 - 0.09 12.5 1.1 0.14 11.9 1.1 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 87 DUF4834 PF16118.5 ETO09729.1 - 1.1 10.3 4.0 0.56 11.2 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO09730.1 - 1.3e-34 117.6 17.4 7.8e-06 26.5 0.9 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO09730.1 - 1.3e-12 47.1 8.3 0.0034 16.1 0.1 5.8 2 1 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09730.1 - 1.5e-10 41.2 1.4 0.022 15.0 0.0 5.9 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain AA_permease PF00324.21 ETO09731.1 - 8.5e-21 74.1 2.7 1.2e-20 73.6 2.7 1.1 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 ETO09731.1 - 5.1e-15 55.4 15.0 6.1e-08 32.1 0.0 2.9 2 1 0 2 2 2 2 Solute carrier family 12 FaeA PF04703.12 ETO09731.1 - 0.19 12.1 0.1 23 5.4 0.1 2.9 2 0 0 2 2 2 0 FaeA-like protein DUF1516 PF07457.11 ETO09731.1 - 0.27 11.4 2.9 0.74 10.0 2.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1516) TctB PF07331.11 ETO09731.1 - 1.5 9.1 6.5 7.4 6.9 6.5 2.2 1 1 0 1 1 1 0 Tripartite tricarboxylate transporter TctB family DUF4205 PF13898.6 ETO09732.1 - 2.7e-10 39.7 0.3 3.5e-05 22.9 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4205) Pox_F16 PF04708.12 ETO09732.1 - 0.14 11.6 1.8 0.3 10.5 1.8 1.5 1 0 0 1 1 1 0 Poxvirus F16 protein Jas PF16135.5 ETO09732.1 - 0.16 12.2 1.5 0.57 10.4 1.5 2.0 1 0 0 1 1 1 0 TPL-binding domain in jasmonate signalling Ras PF00071.22 ETO09733.1 - 9.3e-23 80.6 0.2 1.3e-22 80.1 0.2 1.2 1 0 0 1 1 1 1 Ras family Glyco_hydro_65m PF03632.15 ETO09734.1 - 0.013 14.4 3.8 0.014 14.3 3.8 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 65 central catalytic domain DUF3438 PF11920.8 ETO09734.1 - 0.022 14.0 6.4 0.029 13.6 6.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) V_ATPase_I PF01496.19 ETO09734.1 - 0.13 10.2 9.7 0.13 10.1 9.7 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SOGA PF11365.8 ETO09734.1 - 0.45 11.7 14.0 0.13 13.4 7.0 2.2 1 1 1 2 2 2 0 Protein SOGA DUF4481 PF14800.6 ETO09734.1 - 8.4 5.8 8.3 4.4 6.7 6.2 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4481) DUF89 PF01937.19 ETO09736.1 - 1.2e-39 136.3 0.2 1.4e-39 136.0 0.2 1.0 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF89 PF01937.19 ETO09737.1 - 9e-08 31.4 0.9 1.2e-07 31.0 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF89 DUF3007 PF11460.8 ETO09737.1 - 0.31 11.3 1.4 0.64 10.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) Tudor_4 PF18358.1 ETO09738.1 - 0.013 15.0 0.2 0.026 14.1 0.2 1.5 1 0 0 1 1 1 0 Histone methyltransferase Tudor domain GEN1_C PF18380.1 ETO09739.1 - 0.15 12.9 0.3 0.15 12.9 0.3 4.3 3 1 0 3 3 3 0 Holliday junction resolvase Gen1 C-terminal domain S1FA PF04689.13 ETO09739.1 - 0.16 12.1 0.6 0.42 10.8 0.6 1.7 1 0 0 1 1 1 0 DNA binding protein S1FA Pex24p PF06398.11 ETO09740.1 - 0.067 12.2 3.6 0.071 12.1 2.9 1.3 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin ABC2_membrane_3 PF12698.7 ETO09742.1 - 0.0045 16.2 0.2 0.0045 16.2 0.2 2.9 2 1 0 2 2 2 1 ABC-2 family transporter protein POX PF07526.11 ETO09742.1 - 0.024 15.2 3.5 0.024 15.2 3.5 2.6 3 0 0 3 3 3 0 Associated with HOX Lipase_3 PF01764.25 ETO09743.1 - 4.8e-14 52.4 0.0 2.5e-13 50.1 0.0 2.1 1 1 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ETO09743.1 - 0.0027 17.3 0.0 0.0049 16.5 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Sarcolipin PF05366.11 ETO09743.1 - 0.44 10.3 2.0 0.36 10.6 0.2 1.8 2 0 0 2 2 2 0 Sarcolipin PDDEXK_6 PF04720.12 ETO09743.1 - 1.2 9.1 5.1 2.4 8.1 5.1 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Menin PF05053.13 ETO09743.1 - 8.1 4.7 10.8 12 4.1 10.8 1.2 1 0 0 1 1 1 0 Menin WD40 PF00400.32 ETO09744.1 - 2e-49 164.5 18.5 2.2e-11 44.1 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09744.1 - 4.8e-17 62.0 6.1 0.00053 20.2 0.1 5.8 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09744.1 - 6.7e-08 31.9 1.0 0.33 9.9 0.1 5.4 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09744.1 - 1.1e-07 31.5 0.7 0.081 12.2 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO09744.1 - 8.6e-07 28.0 13.6 0.18 10.4 0.1 5.2 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO09744.1 - 8.8e-05 21.2 1.0 0.56 8.7 0.0 3.5 2 2 2 4 4 4 3 Cytochrome D1 heme domain SGL PF08450.12 ETO09744.1 - 0.00014 21.5 0.2 0.47 10.0 0.1 2.6 2 1 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 ETO09744.1 - 0.0007 19.7 0.3 3.2 7.9 0.0 4.4 3 2 2 5 5 5 1 Strictosidine synthase DUF5570 PF17731.1 ETO09744.1 - 0.0012 19.0 3.0 1.5 8.9 0.0 4.5 2 1 2 5 5 5 1 Family of unknown function (DUF5570) DUF5046 PF16465.5 ETO09744.1 - 0.033 13.7 0.0 5.8 6.3 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) zf-C3HC4_3 PF13920.6 ETO09745.1 - 4.7e-10 39.2 9.2 8.7e-10 38.3 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO09745.1 - 1.4e-09 37.7 8.5 2.5e-09 36.8 8.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_2 PF13923.6 ETO09745.1 - 3.3e-09 36.4 9.0 7.3e-09 35.3 9.0 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO09745.1 - 2e-08 34.0 9.0 6.4e-08 32.4 8.9 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO09745.1 - 2.5e-07 30.6 4.3 7.5e-07 29.1 4.4 1.9 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO09745.1 - 4.5e-07 30.1 9.1 1.1e-06 28.8 9.1 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO09745.1 - 6.4e-07 29.1 10.7 1.8e-06 27.7 10.7 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO09745.1 - 0.00065 19.9 5.2 0.0024 18.1 5.2 2.0 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_6 PF14835.6 ETO09745.1 - 0.0014 18.4 2.3 0.0029 17.5 2.3 1.5 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_4 PF14570.6 ETO09745.1 - 0.17 11.7 9.2 0.11 12.3 6.6 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-ANAPC11 PF12861.7 ETO09745.1 - 0.18 11.9 2.6 0.42 10.7 2.6 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger PikAIV_N PF18605.1 ETO09745.1 - 0.87 9.2 13.9 5.6 6.6 0.4 5.1 5 0 0 5 5 5 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain zf-C3HC4_4 PF15227.6 ETO09745.1 - 1.3 9.3 10.3 0.92 9.7 7.0 2.4 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING DUF3450 PF11932.8 ETO09745.1 - 5.5 6.2 19.5 0.043 13.1 3.6 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO09745.1 - 8.2 6.5 12.3 2.8 8.0 1.3 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) RasGEF PF00617.19 ETO09746.1 - 2.6e-11 44.1 0.0 4.7e-11 43.2 0.0 1.4 1 1 0 1 1 1 1 RasGEF domain Syndecan PF01034.20 ETO09746.1 - 0.015 15.2 0.0 0.032 14.1 0.0 1.6 1 0 0 1 1 1 0 Syndecan domain Cpta_toxin PF07254.12 ETO09746.1 - 0.041 13.9 0.9 0.058 13.4 0.1 1.6 2 0 0 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system RasGEF PF00617.19 ETO09747.1 - 1e-19 71.4 0.4 1e-19 71.4 0.4 1.9 2 0 0 2 2 2 1 RasGEF domain PUB PF09409.10 ETO09747.1 - 2.1e-05 24.4 0.0 8.1e-05 22.5 0.0 2.0 1 0 0 1 1 1 1 PUB domain W2 PF02020.18 ETO09747.1 - 0.049 13.8 0.8 0.049 13.8 0.8 2.3 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon RasGEF_N PF00618.20 ETO09747.1 - 0.078 13.2 5.7 0.069 13.4 2.1 2.8 2 1 0 2 2 2 0 RasGEF N-terminal motif STAG PF08514.11 ETO09747.1 - 5.9 6.8 6.7 48 3.9 0.6 3.7 3 0 0 3 3 3 0 STAG domain Nucleotid_trans PF03407.16 ETO09748.1 - 4e-14 53.1 0.1 4e-14 53.1 0.1 1.6 2 0 0 2 2 1 1 Nucleotide-diphospho-sugar transferase DUF2722 PF10846.8 ETO09748.1 - 0.0016 17.4 9.4 0.0019 17.2 9.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Roughex PF06020.11 ETO09748.1 - 0.0027 16.9 7.0 0.0049 16.0 7.0 1.4 1 0 0 1 1 1 1 Drosophila roughex protein CDC45 PF02724.14 ETO09748.1 - 0.0067 14.8 7.3 0.0087 14.4 7.3 1.1 1 0 0 1 1 1 1 CDC45-like protein DDHD PF02862.17 ETO09748.1 - 0.018 15.2 0.9 0.023 14.9 0.9 1.3 1 0 0 1 1 1 0 DDHD domain XAP5 PF04921.14 ETO09748.1 - 0.022 14.6 5.5 0.035 13.9 5.5 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF775 PF05603.12 ETO09748.1 - 0.024 14.2 2.9 0.049 13.2 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) EOS1 PF12326.8 ETO09748.1 - 0.03 14.3 4.8 0.039 13.9 1.9 2.1 2 0 0 2 2 2 0 N-glycosylation protein Spt20 PF12090.8 ETO09748.1 - 0.036 13.7 17.6 0.053 13.1 17.6 1.2 1 0 0 1 1 1 0 Spt20 family SpoIIP PF07454.11 ETO09748.1 - 0.036 13.5 5.8 0.063 12.7 5.8 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TERB2 PF15101.6 ETO09748.1 - 0.072 13.1 5.8 0.12 12.4 5.8 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 ETO09748.1 - 0.24 10.1 8.0 0.31 9.8 8.0 1.2 1 0 0 1 1 1 0 Presenilin MDM10 PF12519.8 ETO09748.1 - 0.74 8.6 4.2 0.95 8.3 4.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Pex14_N PF04695.13 ETO09748.1 - 0.81 10.3 8.1 1.3 9.7 8.1 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NPR3 PF03666.13 ETO09748.1 - 0.81 8.4 7.7 1.2 7.8 7.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO09748.1 - 0.89 8.7 2.2 1.1 8.4 2.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_S49_N PF08496.10 ETO09748.1 - 1.1 9.3 4.9 6.6 6.8 4.0 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Merozoite_SPAM PF07133.11 ETO09748.1 - 3.2 7.7 16.6 5.4 7.0 16.6 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Eapp_C PF10238.9 ETO09748.1 - 6.9 6.7 12.9 22 5.1 9.9 2.1 2 0 0 2 2 2 0 E2F-associated phosphoprotein Slu7 PF11708.8 ETO09748.1 - 7 6.3 16.3 12 5.6 14.7 1.9 2 0 0 2 2 2 0 Pre-mRNA splicing Prp18-interacting factor UPF0560 PF10577.9 ETO09748.1 - 8.2 4.8 12.1 11 4.4 12.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PH_4 PF15404.6 ETO09748.1 - 8.6 6.1 9.7 82 2.9 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain FOP_dimer PF09398.10 ETO09749.1 - 2.7e-07 30.7 1.5 0.00017 21.8 1.5 3.0 1 1 0 1 1 1 1 FOP N terminal dimerisation domain LisH_2 PF16045.5 ETO09749.1 - 0.0011 17.9 0.7 0.0021 17.0 0.7 1.5 1 0 0 1 1 1 1 LisH ALMT PF11744.8 ETO09750.1 - 5.7 5.6 9.3 0.29 9.9 3.2 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter SLATT_5 PF18160.1 ETO09750.1 - 7.6 5.8 8.2 0.59 9.4 0.6 2.2 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 5 SIR2 PF02146.17 ETO09752.1 - 4.5e-23 82.1 0.1 8.9e-23 81.1 0.1 1.5 1 0 0 1 1 1 1 Sir2 family Neuraminidase PF18413.1 ETO09752.1 - 0.093 12.4 8.0 0.49 10.0 8.0 2.0 1 1 0 1 1 1 0 Neuraminidase-like domain ISG65-75 PF11727.8 ETO09752.1 - 0.31 10.2 11.7 0.89 8.7 7.5 2.6 3 0 0 3 3 3 0 Invariant surface glycoprotein RP-C_C PF11800.8 ETO09752.1 - 0.99 9.5 3.6 2.2 8.3 3.6 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 ETO09752.1 - 2.1 7.0 6.3 7.7 5.2 6.6 1.7 2 0 0 2 2 2 0 Presenilin RNA_pol_Rpc4 PF05132.14 ETO09752.1 - 4.7 7.6 8.3 10 6.5 8.3 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Neur_chan_memb PF02932.16 ETO09753.1 - 0.053 13.6 11.8 0.15 12.1 1.0 2.3 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Ribosomal_L9_N PF01281.19 ETO09754.1 - 2.7e-07 30.0 0.0 4.9e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L9, N-terminal domain Ribosomal_L9_C PF03948.14 ETO09754.1 - 0.032 14.7 0.0 0.082 13.4 0.0 1.6 1 1 0 1 1 1 0 Ribosomal protein L9, C-terminal domain UQ_con PF00179.26 ETO09755.1 - 1e-36 125.6 0.0 1.9e-36 124.8 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF3480 PF11979.8 ETO09755.1 - 0.046 12.7 0.1 0.33 9.9 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3480) DHH PF01368.20 ETO09756.1 - 3.9e-07 30.2 0.8 1.2e-06 28.7 0.4 2.0 1 1 0 1 1 1 1 DHH family DHHA2 PF02833.14 ETO09756.1 - 1.3e-06 28.7 0.8 1.8e-05 25.0 0.0 3.1 3 1 0 3 3 3 1 DHHA2 domain DDHD PF02862.17 ETO09756.1 - 0.042 14.0 1.8 0.051 13.7 0.5 1.8 2 0 0 2 2 2 0 DDHD domain DUF5436 PF17504.2 ETO09756.1 - 1.7 9.0 4.9 0.52 10.7 0.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5436) CobT PF06213.12 ETO09756.1 - 3 7.2 7.4 0.39 10.1 1.8 1.9 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT XK-related PF09815.9 ETO09757.1 - 0.58 9.2 14.3 0.057 12.5 7.4 2.5 2 2 1 3 3 3 0 XK-related protein B56 PF01603.20 ETO09758.1 - 8.7e-25 87.5 0.4 9.9e-25 87.4 0.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) B56 PF01603.20 ETO09759.1 - 2.8e-95 319.8 12.7 4.5e-91 305.9 3.6 2.0 1 1 1 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) Annexin PF00191.20 ETO09760.1 - 8e-18 64.3 0.5 0.0011 18.9 0.0 4.3 4 0 0 4 4 4 4 Annexin RebB PF11747.8 ETO09760.1 - 0.77 9.9 2.9 1.8 8.7 0.3 2.6 2 0 0 2 2 2 0 Killing trait Ras PF00071.22 ETO09761.1 - 0.00015 21.4 0.1 0.00015 21.4 0.1 1.7 2 0 0 2 2 2 1 Ras family FliP PF00813.20 ETO09761.1 - 0.17 11.8 3.1 2.5 7.9 0.0 2.2 2 0 0 2 2 2 0 FliP family PIN_12 PF16289.5 ETO09761.1 - 6.1 7.3 16.7 12 6.3 8.8 2.3 2 0 0 2 2 2 0 PIN domain EF-hand_1 PF00036.32 ETO09762.1 - 4e-25 85.4 18.7 3e-07 29.5 1.6 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETO09762.1 - 1.5e-20 73.4 7.3 4.8e-12 46.2 1.0 3.5 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO09762.1 - 7e-19 66.1 16.0 1.4e-06 27.8 0.1 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ETO09762.1 - 7.1e-17 60.1 22.2 3.8e-06 26.2 0.1 5.2 5 0 0 5 5 5 4 EF hand EF-hand_8 PF13833.6 ETO09762.1 - 2.9e-10 39.8 12.1 0.0015 18.3 0.9 4.4 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO09762.1 - 1e-06 28.7 1.9 0.02 14.8 0.0 3.6 3 1 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand DUF1388 PF07142.12 ETO09762.1 - 5.3e-05 23.1 3.2 5.3e-05 23.1 3.2 2.6 1 1 1 2 2 2 1 Repeat of unknown function (DUF1388) SPARC_Ca_bdg PF10591.9 ETO09762.1 - 0.00076 19.8 3.1 0.0036 17.6 0.0 3.0 2 1 1 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region DAAD PF18752.1 ETO09762.1 - 0.006 16.5 5.5 0.0093 15.8 5.5 1.2 1 0 0 1 1 1 1 Dictyosteliid AID/APOBEC-like Deaminase EF-hand_9 PF14658.6 ETO09762.1 - 0.021 15.1 1.0 1.3 9.4 0.0 3.3 3 1 1 4 4 4 0 EF-hand domain DUF4778 PF16008.5 ETO09762.1 - 0.044 13.9 1.0 0.069 13.2 1.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) RRN3 PF05327.11 ETO09762.1 - 0.097 11.2 1.0 0.19 10.2 1.0 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BSP_II PF05432.11 ETO09762.1 - 0.16 11.6 27.3 0.4 10.3 27.3 1.6 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SLC12 PF03522.15 ETO09762.1 - 0.22 10.5 7.9 0.63 9.0 8.4 1.5 2 0 0 2 2 2 0 Solute carrier family 12 Ndc1_Nup PF09531.10 ETO09762.1 - 0.4 9.3 2.4 0.46 9.1 2.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Amelogenin PF02948.15 ETO09762.1 - 0.96 10.1 7.7 1.5 9.4 7.7 1.3 1 0 0 1 1 1 0 Amelogenin CNDH2_C PF16858.5 ETO09762.1 - 1.1 9.1 18.5 1.7 8.5 18.5 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF5523 PF17661.1 ETO09762.1 - 1.5 8.5 24.0 2.1 8.0 24.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Astro_capsid_p PF12226.8 ETO09762.1 - 1.5 7.9 14.8 2.2 7.4 14.8 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CAC1F_C PF16885.5 ETO09762.1 - 2.4 7.8 15.2 4.1 7.0 15.2 1.4 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term PI3K_1B_p101 PF10486.9 ETO09762.1 - 3.3 5.4 7.2 5.4 4.7 7.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DNA_pol_phi PF04931.13 ETO09762.1 - 3.9 5.5 17.1 6 4.8 17.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi CDC27 PF09507.10 ETO09762.1 - 6.9 6.0 33.4 8.7 5.6 33.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Arm PF00514.23 ETO09763.1 - 2.6e-14 52.7 6.1 2.6e-09 36.8 0.2 3.4 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 ETO09763.1 - 7.9e-09 34.9 0.6 1.5e-08 34.1 0.6 1.5 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 ETO09763.1 - 0.00069 20.1 0.1 0.0033 17.9 0.0 2.1 2 0 0 2 2 2 1 HEAT-like repeat HEAT_2 PF13646.6 ETO09763.1 - 0.0017 18.7 0.1 0.012 15.9 0.1 2.3 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 ETO09763.1 - 0.055 13.8 1.0 0.8 10.1 0.1 2.6 2 0 0 2 2 2 0 HEAT repeat WD40 PF00400.32 ETO09764.1 - 8.2e-62 203.7 22.0 1.4e-11 44.7 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09764.1 - 2.4e-20 72.6 3.8 0.0001 22.5 0.0 5.6 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09764.1 - 5.1e-08 32.3 1.8 0.49 9.3 0.0 5.3 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO09764.1 - 6.8e-08 32.6 0.2 0.0041 17.0 0.1 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO09764.1 - 4.2e-07 29.0 1.8 0.95 8.0 0.0 4.5 2 2 3 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09764.1 - 5.7e-07 29.1 1.9 0.033 13.5 0.1 3.2 2 1 1 3 3 3 3 WD40-like domain Coatomer_WDAD PF04053.14 ETO09764.1 - 0.00028 20.1 1.8 1.4 7.9 0.0 3.0 1 1 2 3 3 3 2 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO09764.1 - 0.00079 18.3 6.6 0.54 8.9 0.4 4.3 2 2 2 4 4 3 2 Nup133 N terminal like DUF5570 PF17731.1 ETO09764.1 - 0.0011 19.0 1.0 10 6.2 0.0 4.4 2 2 3 5 5 5 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO09764.1 - 0.0051 15.4 2.5 0.6 8.6 0.2 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO09764.1 - 0.0088 15.4 0.8 5.6 6.2 0.0 3.0 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal ArlS_N PF18719.1 ETO09764.1 - 0.014 15.6 0.1 11 6.2 0.0 3.6 3 1 1 4 4 4 0 ArlS sensor domain Me-amine-dh_H PF06433.11 ETO09764.1 - 0.016 14.0 0.1 1.1 8.0 0.0 2.7 2 1 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO09764.1 - 0.07 13.1 3.5 31 4.6 0.0 4.9 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Utp8 PF10395.9 ETO09764.1 - 0.086 11.3 0.1 1 7.7 0.0 2.0 1 1 1 2 2 2 0 Utp8 family Lactonase PF10282.9 ETO09764.1 - 0.095 11.9 0.0 0.36 10.0 0.0 1.7 1 1 0 2 2 2 0 Lactonase, 7-bladed beta-propeller HPS6 PF15702.5 ETO09764.1 - 0.11 10.4 0.0 2.2 6.1 0.0 2.6 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 6 protein CDC45 PF02724.14 ETO09766.1 - 0.0093 14.3 25.7 0.013 13.9 25.7 1.2 1 0 0 1 1 1 1 CDC45-like protein COPI_C PF06957.11 ETO09766.1 - 2.5 6.8 12.7 3.7 6.2 12.7 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Presenilin PF01080.17 ETO09767.1 - 0.14 10.9 6.7 0.2 10.4 6.7 1.3 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO09767.1 - 0.28 11.2 5.9 0.48 10.4 5.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO09767.1 - 0.7 9.0 4.8 0.86 8.8 4.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Dsh_C PF12316.8 ETO09767.1 - 0.83 10.0 5.3 0.2 12.0 0.9 2.1 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal DUF2400 PF09674.10 ETO09767.1 - 3.5 7.6 8.4 0.79 9.7 0.8 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2400) WD40 PF00400.32 ETO09768.1 - 3.8e-67 220.6 14.4 2.6e-11 43.9 0.1 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09768.1 - 7.2e-24 83.9 0.7 0.0054 17.0 0.0 6.8 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09768.1 - 1.6e-16 60.2 0.6 0.01 14.9 0.0 6.0 2 2 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO09768.1 - 4.7e-12 46.2 1.8 6.1e-07 29.5 0.4 3.4 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO09768.1 - 4.4e-08 32.8 0.9 0.00027 20.4 0.1 3.5 1 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO09768.1 - 7.7e-08 31.2 0.2 0.054 12.0 0.0 3.8 1 1 3 4 4 4 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO09768.1 - 1.2e-06 27.5 4.9 1.1 7.8 0.0 5.4 1 1 3 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO09768.1 - 6.2e-05 22.8 7.0 6.7 6.8 0.0 5.5 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO09768.1 - 0.00015 20.6 4.6 0.93 8.2 0.0 3.8 1 1 2 3 3 3 2 Nup133 N terminal like DUF5449 PF17528.2 ETO09768.1 - 0.0021 17.9 0.3 0.28 10.9 0.0 2.5 2 1 0 2 2 2 1 Family of unknown function (DUF5449) AcetylCoA_hyd_C PF13336.6 ETO09768.1 - 0.0093 15.9 0.1 9.9 6.1 0.0 3.5 3 1 1 4 4 4 1 Acetyl-CoA hydrolase/transferase C-terminal domain HPS3_N PF14761.6 ETO09768.1 - 0.01 15.4 0.0 0.082 12.4 0.0 2.3 1 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 Utp8 PF10395.9 ETO09768.1 - 0.036 12.6 0.3 0.54 8.7 0.0 2.1 1 1 1 2 2 2 0 Utp8 family zf-C2H2 PF00096.26 ETO09769.1 - 1.5e-10 40.9 52.7 0.0026 18.1 1.7 6.7 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO09769.1 - 4.2e-06 27.1 56.4 0.15 12.9 0.8 7.0 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO09769.1 - 0.0055 17.1 5.3 0.0055 17.1 5.3 7.7 7 2 0 7 7 7 2 Zinc-finger double domain zf-C2H2_11 PF16622.5 ETO09769.1 - 0.021 14.6 0.3 0.021 14.6 0.3 4.8 5 0 0 5 5 5 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ETO09769.1 - 0.074 13.1 0.4 0.074 13.1 0.4 5.4 5 0 0 5 5 5 0 C2H2-type zinc finger zf-met PF12874.7 ETO09769.1 - 0.19 12.1 0.2 0.19 12.1 0.2 5.1 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-Sec23_Sec24 PF04810.15 ETO09769.1 - 3 8.0 21.1 0.38 10.8 0.2 4.1 3 1 0 3 3 3 0 Sec23/Sec24 zinc finger zf-C2H2_8 PF15909.5 ETO09769.1 - 5.7 7.3 31.7 0.08 13.2 11.3 3.7 2 1 1 3 3 3 0 C2H2-type zinc ribbon AAA_12 PF13087.6 ETO09770.1 - 0.0032 17.1 0.4 0.0064 16.1 0.4 1.4 1 0 0 1 1 1 1 AAA domain 7tm_1 PF00001.21 ETO09771.1 - 1.8e-05 24.2 0.1 2.4e-05 23.8 0.1 1.2 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Dicty_CAR PF05462.11 ETO09771.1 - 0.00057 19.1 0.6 0.00057 19.1 0.6 1.5 2 0 0 2 2 2 1 Slime mold cyclic AMP receptor FAM176 PF14851.6 ETO09771.1 - 0.0045 16.6 0.0 0.0063 16.2 0.0 1.2 1 0 0 1 1 1 1 FAM176 family Connexin PF00029.19 ETO09771.1 - 0.012 15.4 0.1 0.018 14.8 0.1 1.2 1 1 0 1 1 1 0 Connexin tRNA_anti-like PF12869.7 ETO09771.1 - 0.023 14.3 0.0 0.03 13.9 0.0 1.2 1 0 0 1 1 1 0 tRNA_anti-like OATP PF03137.20 ETO09771.1 - 0.033 12.5 0.0 0.035 12.4 0.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family GPR_Gpa2_C PF11970.8 ETO09771.1 - 0.034 14.2 2.5 0.034 14.2 2.5 1.7 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term SIL1 PF16782.5 ETO09771.1 - 0.045 13.0 0.5 0.081 12.1 0.5 1.4 2 0 0 2 2 2 0 Nucleotide exchange factor SIL1 DUF3377 PF11857.8 ETO09771.1 - 0.052 13.5 0.1 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF2207 PF09972.9 ETO09771.1 - 0.052 12.3 0.1 0.15 10.8 0.0 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) YMF19 PF02326.15 ETO09771.1 - 0.056 14.2 0.0 0.056 14.2 0.0 1.9 1 1 1 2 2 2 0 Plant ATP synthase F0 TRAP_alpha PF03896.16 ETO09771.1 - 0.056 12.6 0.0 0.071 12.3 0.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit EMC3_TMCO1 PF01956.16 ETO09771.1 - 0.1 12.3 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF2897 PF11446.8 ETO09771.1 - 0.15 12.0 0.0 0.3 11.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2897) DUF2428 PF10350.9 ETO09771.1 - 0.16 11.2 0.0 0.2 10.9 0.0 1.1 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) PIG-P PF08510.12 ETO09771.1 - 0.25 11.3 2.7 0.91 9.4 0.1 2.4 2 1 1 3 3 3 0 PIG-P CENP-B_dimeris PF09026.10 ETO09771.1 - 0.34 11.3 3.9 0.54 10.7 3.9 1.4 1 1 0 1 1 1 0 Centromere protein B dimerisation domain Chordopox_G3 PF06129.12 ETO09771.1 - 0.41 11.4 1.6 1.1 10.0 0.0 2.1 2 0 0 2 2 2 0 Chordopoxvirus G3 protein Renin_r PF07850.14 ETO09771.1 - 0.54 10.9 1.8 18 6.0 0.4 2.3 1 1 1 2 2 2 0 Renin receptor-like protein O-antigen_lig PF13425.6 ETO09771.1 - 0.55 8.9 3.9 0.15 10.8 0.8 1.5 1 1 1 2 2 2 0 O-antigen ligase like membrane protein Orf78 PF06024.12 ETO09771.1 - 0.99 9.7 0.0 0.99 9.7 0.0 2.1 1 1 1 2 2 2 0 Orf78 (ac78) NOA36 PF06524.12 ETO09771.1 - 1.3 8.3 4.3 1.7 7.9 4.3 1.1 1 0 0 1 1 1 0 NOA36 protein PBP_sp32 PF07222.12 ETO09771.1 - 3.2 7.1 6.7 4.5 6.7 6.7 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 TPR_17 PF13431.6 ETO09772.1 - 1.8e-10 40.4 2.9 8.6e-06 25.8 0.2 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09772.1 - 6.5e-10 38.4 0.2 9.5e-06 25.2 0.0 2.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09772.1 - 3.9e-08 32.8 0.2 0.0071 16.4 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09772.1 - 6.5e-08 32.2 0.1 0.0026 17.8 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09772.1 - 1.6e-07 30.9 0.0 0.00056 19.5 0.0 2.2 1 1 1 2 2 2 2 TPR repeat TPR_12 PF13424.6 ETO09772.1 - 2.4e-06 27.7 0.1 0.0076 16.5 0.1 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09772.1 - 0.0014 18.5 0.0 2.9 8.1 0.0 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO09772.1 - 0.0067 16.9 0.0 0.012 16.1 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO09772.1 - 0.0075 17.0 0.0 1.5 9.9 0.0 2.4 1 1 1 2 2 2 1 Tetratricopeptide repeat TIR-like PF10137.9 ETO09773.1 - 0.0046 16.9 0.1 0.0082 16.1 0.1 1.4 1 0 0 1 1 1 1 Predicted nucleotide-binding protein containing TIR-like domain Bac_globin PF01152.21 ETO09773.1 - 0.095 12.8 0.5 0.18 11.9 0.5 1.4 1 0 0 1 1 1 0 Bacterial-like globin Consortin_C PF15281.6 ETO09773.1 - 0.16 12.0 2.4 3.5 7.6 0.3 2.6 2 0 0 2 2 2 0 Consortin C-terminus DUF948 PF06103.11 ETO09773.1 - 0.27 11.5 2.7 10 6.5 1.0 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Fzo_mitofusin PF04799.13 ETO09773.1 - 0.4 10.2 3.3 0.85 9.1 3.3 1.5 1 0 0 1 1 1 0 fzo-like conserved region DUF745 PF05335.13 ETO09773.1 - 0.82 9.4 14.7 0.063 13.0 5.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF745) adh_short PF00106.25 ETO09774.1 - 7.9e-26 90.7 0.2 2.7e-20 72.6 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO09774.1 - 3e-14 53.2 0.0 6.5e-11 42.2 0.0 2.2 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO09774.1 - 5.4e-06 26.4 0.0 9.4e-06 25.6 0.0 1.3 1 0 0 1 1 1 1 KR domain VD10_N PF08476.10 ETO09774.1 - 0.015 14.9 0.1 10 5.9 0.0 2.8 2 0 0 2 2 2 0 Viral D10 N-terminal FmdE PF02663.14 ETO09774.1 - 0.051 13.6 0.1 0.11 12.5 0.1 1.5 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Epimerase PF01370.21 ETO09774.1 - 0.061 12.8 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family AcylCoA_dehyd_C PF12186.8 ETO09774.1 - 0.062 13.4 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Acyl-CoA dehydrogenase C terminal Methyltransf_31 PF13847.6 ETO09775.1 - 1e-08 35.2 0.2 2.3e-08 34.0 0.2 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO09775.1 - 1.6e-07 32.0 0.0 5.5e-07 30.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO09775.1 - 2.8e-07 31.1 0.0 0.00026 21.6 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_23 PF13489.6 ETO09775.1 - 1.6e-06 28.1 0.2 3.4e-06 27.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO09775.1 - 7.1e-06 26.7 0.1 7.1e-05 23.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain DOT1 PF08123.13 ETO09775.1 - 3e-05 23.7 0.6 0.00011 21.8 0.6 2.0 1 1 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_4 PF02390.17 ETO09775.1 - 6.5e-05 22.5 0.0 0.00013 21.4 0.0 1.6 1 0 0 1 1 1 1 Putative methyltransferase RrnaAD PF00398.20 ETO09775.1 - 0.0002 20.5 0.0 0.00034 19.8 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase MetW PF07021.12 ETO09775.1 - 0.00084 19.0 0.1 0.0021 17.7 0.1 1.6 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW CMAS PF02353.20 ETO09775.1 - 0.0017 17.7 0.6 0.018 14.3 0.6 2.2 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 ETO09775.1 - 0.0063 16.4 0.2 0.017 15.1 0.2 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_5 PF01795.19 ETO09775.1 - 0.0081 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 MraW methylase family Methyltransf_32 PF13679.6 ETO09775.1 - 0.014 15.4 0.0 0.041 13.9 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_33 PF10017.9 ETO09775.1 - 0.023 13.8 0.0 0.04 13.1 0.0 1.3 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent TMCO5 PF14992.6 ETO09775.1 - 0.095 12.3 1.0 0.19 11.3 1.0 1.4 1 0 0 1 1 1 0 TMCO5 family Tmemb_9 PF05434.11 ETO09776.1 - 0.0085 16.0 1.0 0.0085 16.0 1.0 2.4 1 1 2 3 3 3 1 TMEM9 Cut12 PF11500.8 ETO09776.1 - 0.01 15.8 3.7 0.01 15.8 3.7 1.9 2 0 0 2 2 2 0 Spindle pole body formation-associated protein SR-25 PF10500.9 ETO09776.1 - 0.014 15.0 0.7 0.014 15.0 0.7 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RsgI_N PF12791.7 ETO09776.1 - 0.066 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Anti-sigma factor N-terminus YusW PF14039.6 ETO09776.1 - 0.11 13.0 0.4 0.11 13.0 0.4 2.0 2 0 0 2 2 2 0 YusW-like protein DUF4834 PF16118.5 ETO09776.1 - 0.11 13.4 0.6 0.11 13.4 0.6 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) RNA_polI_A14 PF08203.11 ETO09776.1 - 0.48 11.2 5.0 13 6.6 0.0 3.6 4 0 0 4 4 4 0 Yeast RNA polymerase I subunit RPA14 SID-1_RNA_chan PF13965.6 ETO09776.1 - 4.2 5.7 7.5 0.3 9.5 0.2 1.9 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 EMC3_TMCO1 PF01956.16 ETO09776.1 - 10 5.8 12.5 0.45 10.2 3.7 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like NLRC4_HD PF17889.1 ETO09777.1 - 0.0056 17.0 0.4 0.02 15.2 0.0 2.1 2 1 0 2 2 2 1 NLRC4 helical domain RTTN_N PF14726.6 ETO09778.1 - 0.17 12.7 2.1 36 5.3 0.2 3.3 2 1 1 3 3 3 0 Rotatin, an armadillo repeat protein, centriole functioning INSC_LBD PF16748.5 ETO09779.1 - 0.008 15.6 1.4 0.02 14.4 1.4 1.6 1 0 0 1 1 1 1 Inscuteable LGN-binding domain DUF2841 PF11001.8 ETO09779.1 - 0.36 10.9 9.6 0.95 9.5 7.2 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF2841) NADH_4Fe-4S PF10589.9 ETO09779.1 - 1.3 9.2 6.1 9.8 6.3 4.2 2.7 2 1 0 2 2 2 0 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region FAM216B PF15107.6 ETO09780.1 - 0.054 13.4 0.0 0.12 12.3 0.0 1.6 1 0 0 1 1 1 0 FAM216B protein family XAP5 PF04921.14 ETO09780.1 - 0.86 9.4 17.4 0.31 10.8 13.2 2.0 2 0 0 2 2 2 0 XAP5, circadian clock regulator CDC45 PF02724.14 ETO09780.1 - 3.4 5.9 16.2 0.28 9.4 10.8 1.7 2 0 0 2 2 2 0 CDC45-like protein NIF PF03031.18 ETO09781.1 - 0.00078 19.2 0.0 0.0017 18.2 0.0 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase CAF20 PF17052.5 ETO09781.1 - 0.63 10.2 6.4 0.43 10.7 4.2 1.6 2 1 0 2 2 2 0 Cap associated factor RhlB PF12300.8 ETO09781.1 - 7.7 6.6 10.5 16 5.6 10.5 1.5 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB Borrelia_P83 PF05262.11 ETO09782.1 - 1.8 7.0 20.8 0.017 13.7 13.0 1.6 2 0 0 2 2 2 0 Borrelia P83/100 protein DUF4407 PF14362.6 ETO09782.1 - 2.3 7.5 10.1 3.9 6.7 10.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spore_coat_CotO PF14153.6 ETO09782.1 - 4 7.3 29.7 0.069 13.1 21.4 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Pyr_redox_2 PF07992.14 ETO09783.1 - 3.2e-27 95.6 0.0 3.6e-27 95.4 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO09783.1 - 4.2e-10 39.4 0.0 6.6e-10 38.7 0.0 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO09783.1 - 7.5e-10 39.2 0.5 3.1e-09 37.2 0.1 2.2 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO09783.1 - 4e-07 29.5 0.0 5.6e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_8 PF13450.6 ETO09783.1 - 0.023 14.9 0.1 3.8 7.8 0.0 2.3 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain 2-Hacid_dh_C PF02826.19 ETO09783.1 - 0.12 11.7 0.0 0.2 11.0 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ETO09783.1 - 0.17 11.8 0.0 0.33 10.8 0.0 1.5 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DctQ PF04290.12 ETO09784.1 - 1.4 8.8 12.8 0.25 11.3 1.5 3.0 3 0 0 3 3 3 0 Tripartite ATP-independent periplasmic transporters, DctQ component TMEM208_SND2 PF05620.11 ETO09784.1 - 7.8 6.2 13.3 5.5 6.7 0.4 3.2 2 1 1 3 3 3 0 SRP-independent targeting protein 2/TMEM208 DUF3377 PF11857.8 ETO09784.1 - 8.2 6.4 6.7 2.7 8.0 0.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) PH PF00169.29 ETO09785.1 - 1.8e-11 44.5 3.3 1e-10 42.1 3.3 2.2 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO09785.1 - 5.1e-08 33.3 1.4 5.1e-08 33.3 1.4 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ETO09785.1 - 0.00014 22.1 6.4 0.0087 16.3 0.2 3.1 4 0 0 4 4 4 2 Pleckstrin homology domain zf-TRAF PF02176.18 ETO09785.1 - 0.00041 21.0 7.4 0.00096 19.8 7.4 1.7 1 0 0 1 1 1 1 TRAF-type zinc finger PH_2 PF08458.10 ETO09785.1 - 0.021 15.1 3.3 0.033 14.6 0.1 2.5 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_9 PF15410.6 ETO09785.1 - 0.036 14.4 4.9 1.5 9.2 0.1 2.9 3 0 0 3 3 3 0 Pleckstrin homology domain DUF281 PF03436.13 ETO09785.1 - 0.092 13.2 0.8 0.28 11.6 0.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF281) FapA PF03961.13 ETO09785.1 - 0.38 9.3 4.7 0.6 8.7 4.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1129 PF06570.11 ETO09788.1 - 0.11 12.0 0.0 0.29 10.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1129) Phage_holin_2_4 PF16082.5 ETO09788.1 - 0.18 11.5 0.2 0.65 9.8 0.0 2.0 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like DUF2448 PF10476.9 ETO09788.1 - 0.31 10.9 3.4 6 6.7 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) HNF-1_N PF04814.13 ETO09789.1 - 0.027 15.1 2.2 0.027 15.1 2.2 3.9 3 2 0 3 3 3 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus ABC_tran PF00005.27 ETO09790.1 - 1.2e-21 77.7 0.0 2.1e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ETO09790.1 - 0.022 15.3 0.1 0.044 14.3 0.0 1.5 2 0 0 2 2 2 0 AAA domain DUF4181 PF13789.6 ETO09790.1 - 0.11 12.7 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) SRP54 PF00448.22 ETO09790.1 - 0.16 11.6 0.7 0.35 10.5 0.7 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain DUF4162 PF13732.6 ETO09791.1 - 0.00052 20.7 1.1 0.0033 18.1 1.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4162) 7TM_GPCR_Sri PF10327.9 ETO09791.1 - 0.00054 19.2 0.6 0.00065 19.0 0.6 1.1 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Sri DUF5627 PF18620.1 ETO09791.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5627) Transketolase_C PF02780.20 ETO09792.1 - 8.5e-40 135.5 0.0 2e-39 134.3 0.0 1.5 2 0 0 2 2 2 1 Transketolase, C-terminal domain Transket_pyr PF02779.24 ETO09792.1 - 0.017 14.8 0.0 0.037 13.7 0.0 1.5 2 0 0 2 2 2 0 Transketolase, pyrimidine binding domain cwf21 PF08312.12 ETO09793.1 - 0.0011 19.0 2.0 0.0025 17.9 2.0 1.6 1 0 0 1 1 1 1 cwf21 domain Phosphoesterase PF04185.14 ETO09794.1 - 0.12 11.6 0.0 0.13 11.4 0.0 1.1 1 0 0 1 1 1 0 Phosphoesterase family Pkinase PF00069.25 ETO09794.1 - 0.13 11.6 0.1 0.45 9.8 0.0 1.8 2 0 0 2 2 2 0 Protein kinase domain Pkinase PF00069.25 ETO09795.1 - 2.7e-38 131.8 0.7 2e-22 79.8 0.3 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09795.1 - 2.2e-13 50.1 0.2 3.7e-06 26.4 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ETO09795.1 - 0.0087 16.0 0.0 0.013 15.5 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family DUF3941 PF13081.6 ETO09795.1 - 0.076 13.4 1.3 0.25 11.8 1.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3941) HTH_Tnp_Tc3_2 PF01498.18 ETO09796.1 - 3.3e-05 24.0 0.3 9.5e-05 22.6 0.3 1.7 1 0 0 1 1 1 1 Transposase Aldedh PF00171.22 ETO09797.1 - 5.5e-69 232.9 0.0 2.9e-35 121.7 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family LuxC PF05893.14 ETO09797.1 - 0.0006 19.0 0.0 0.00083 18.5 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) WD40 PF00400.32 ETO09798.1 - 4.9e-118 381.6 41.8 1.3e-08 35.4 0.1 17.0 15 1 1 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09798.1 - 4.9e-28 97.3 15.2 0.031 14.6 0.0 12.5 1 1 12 13 13 13 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09798.1 - 1.2e-16 60.7 15.6 0.33 9.9 0.0 11.4 2 1 8 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO09798.1 - 1.6e-10 41.2 0.0 5.4e-10 39.4 0.0 1.9 2 0 0 2 2 2 1 NACHT domain Cytochrom_D1 PF02239.16 ETO09798.1 - 5.6e-06 25.1 5.4 0.38 9.2 0.0 4.9 3 1 1 5 5 5 2 Cytochrome D1 heme domain SGL PF08450.12 ETO09798.1 - 1.4e-05 24.8 1.3 1.6 8.2 0.2 5.3 2 2 2 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region Pentapeptide PF00805.22 ETO09798.1 - 2.2e-05 24.0 1.7 2.2e-05 24.0 1.7 2.1 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) DUF5046 PF16465.5 ETO09798.1 - 2.8e-05 23.7 0.1 0.1 12.0 0.0 4.2 2 1 4 6 6 6 1 Domain of unknown function (DUF5046) Pentapeptide_4 PF13599.6 ETO09798.1 - 0.00067 19.8 0.3 0.00067 19.8 0.3 2.4 2 0 0 2 2 1 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO09798.1 - 0.0024 17.3 2.3 11 5.2 0.0 5.1 3 1 1 5 5 5 0 Neuroblastoma-amplified sequence, N terminal Resistin PF06954.11 ETO09798.1 - 0.014 15.9 0.0 31 5.2 0.0 5.1 3 1 2 5 5 5 0 Resistin DUF1938 PF09153.10 ETO09798.1 - 0.014 15.4 0.9 0.3 11.2 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF1938) AAA_22 PF13401.6 ETO09798.1 - 0.024 14.9 0.2 0.19 12.0 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO09798.1 - 0.05 14.2 1.6 0.7 10.4 1.6 3.2 1 1 0 1 1 1 0 AAA domain DUF241 PF03087.14 ETO09798.1 - 0.081 12.8 1.1 0.39 10.5 1.1 2.2 1 0 0 1 1 1 0 Arabidopsis protein of unknown function Pentapeptide_3 PF13576.6 ETO09798.1 - 0.088 13.0 0.7 0.78 9.9 0.1 2.6 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) AAA PF00004.29 ETO09798.1 - 0.098 13.1 3.6 0.63 10.5 0.0 3.3 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) ABC_tran PF00005.27 ETO09798.1 - 0.16 12.5 2.6 0.6 10.6 0.0 3.0 2 0 0 2 2 2 0 ABC transporter PD40 PF07676.12 ETO09798.1 - 2.7 8.0 17.1 1.1e+02 2.9 0.0 8.6 12 0 0 12 12 10 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO09799.1 - 4.1e-29 100.2 12.6 2e-06 28.4 0.1 6.5 5 1 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO09799.1 - 5.8e-10 38.4 0.3 0.00088 18.0 0.0 4.5 2 2 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09799.1 - 2.2e-09 37.5 0.1 0.13 12.6 0.0 5.2 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO09799.1 - 3.5e-05 24.4 5.4 0.00016 22.3 5.0 2.5 1 1 1 2 2 2 1 TRAF-type zinc finger Gal-3-0_sulfotr PF06990.11 ETO09801.1 - 0.11 11.4 0.6 0.14 11.0 0.6 1.2 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase DUF728 PF05304.12 ETO09802.1 - 0.33 10.8 4.6 0.14 12.0 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF728) TLD PF07534.16 ETO09803.1 - 1e-09 38.7 0.4 1.7e-09 38.0 0.4 1.3 1 0 0 1 1 1 1 TLD Pro_isomerase PF00160.21 ETO09804.1 - 3.6e-43 147.6 0.4 7.5e-43 146.5 0.4 1.5 1 1 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD HAD_2 PF13419.6 ETO09808.1 - 5.3e-09 36.4 1.0 0.0009 19.4 0.5 2.4 2 0 0 2 2 2 2 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETO09808.1 - 3.8e-08 33.3 0.0 6.3e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like HAD PF12710.7 ETO09808.1 - 0.013 15.9 0.1 0.17 12.3 0.1 2.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase CelD_N PF02927.14 ETO09808.1 - 0.031 15.2 0.0 0.061 14.2 0.0 1.5 1 0 0 1 1 1 0 Cellulase N-terminal ig-like domain Hydrolase PF00702.26 ETO09808.1 - 0.07 13.4 0.0 0.27 11.5 0.0 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase RCC1 PF00415.18 ETO09809.1 - 1.5e-24 86.3 0.1 2.4e-10 40.9 0.0 5.4 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO09809.1 - 0.00016 21.4 12.3 0.0098 15.7 0.0 4.6 4 1 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat PGA_cap PF09587.10 ETO09809.1 - 0.22 11.0 0.0 0.37 10.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap TPR_12 PF13424.6 ETO09810.1 - 3.4e-31 107.3 2.1 1.1e-16 60.9 0.1 3.4 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO09810.1 - 3.3e-26 90.3 0.5 4.6e-09 35.9 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09810.1 - 3.2e-19 67.5 1.3 1.3e-08 34.2 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09810.1 - 8.2e-18 63.1 8.8 9e-08 31.8 0.5 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09810.1 - 1.4e-17 62.7 9.3 3.8e-08 32.8 0.6 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09810.1 - 1.1e-15 56.3 6.5 8.5e-06 25.5 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO09810.1 - 7.8e-06 25.9 1.4 0.29 11.6 0.1 3.6 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO09810.1 - 0.0002 21.0 6.2 0.31 10.8 0.4 4.6 4 1 0 4 4 4 1 TPR repeat TPR_6 PF13174.6 ETO09810.1 - 0.00033 21.1 0.1 21 6.0 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO09810.1 - 0.004 17.8 0.0 2.4 8.9 0.0 3.6 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO09810.1 - 0.0051 17.5 0.0 11 7.1 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO09810.1 - 0.012 15.6 4.1 4.2 7.5 0.2 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat SNAP PF14938.6 ETO09810.1 - 0.015 14.7 0.1 0.49 9.8 0.1 2.9 3 0 0 3 3 3 0 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO09810.1 - 0.032 14.3 2.8 4.5 7.4 0.2 3.4 3 0 0 3 3 2 0 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO09810.1 - 0.051 13.4 5.7 2.3 8.0 0.1 3.3 4 0 0 4 4 3 0 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETO09810.1 - 0.074 13.8 0.3 20 6.0 0.0 3.4 3 0 0 3 3 3 0 Sel1 repeat PPR PF01535.20 ETO09810.1 - 0.14 12.5 3.6 5 7.6 0.1 3.8 4 0 0 4 4 4 0 PPR repeat TPR_MalT PF17874.1 ETO09810.1 - 0.15 11.4 0.0 0.26 10.6 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region DUF3605 PF12239.8 ETO09811.1 - 1.3e-07 32.1 0.7 1.9e-07 31.5 0.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) LRR_6 PF13516.6 ETO09812.1 - 3.6e-06 26.6 19.3 0.27 11.4 0.0 6.8 7 0 0 7 7 7 3 Leucine Rich repeat LRR_4 PF12799.7 ETO09812.1 - 0.0024 18.3 12.8 0.076 13.5 0.1 4.4 4 1 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO09812.1 - 0.0079 16.6 11.7 8 7.4 0.0 5.9 7 0 0 7 7 7 2 Leucine Rich Repeat MRPL52 PF18699.1 ETO09813.1 - 0.056 13.6 0.7 0.091 13.0 0.7 1.4 1 0 0 1 1 1 0 Mitoribosomal protein mL52 CLN3 PF02487.17 ETO09814.1 - 0.026 13.6 0.1 0.059 12.4 0.0 1.5 2 0 0 2 2 2 0 CLN3 protein OAD_gamma PF04277.13 ETO09814.1 - 0.044 14.4 0.6 4.7 7.9 0.3 2.4 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain TRAP_alpha PF03896.16 ETO09814.1 - 0.17 11.0 2.4 0.86 8.8 1.6 2.0 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit NIF PF03031.18 ETO09814.1 - 0.35 10.6 3.2 0.58 9.9 2.0 1.9 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase WD40 PF00400.32 ETO09815.1 - 7.3e-53 175.4 12.9 1.6e-10 41.3 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09815.1 - 4.7e-18 65.3 1.0 0.00016 21.9 0.0 5.6 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09815.1 - 1.9e-14 53.4 0.5 0.0014 17.7 0.0 5.9 1 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO09815.1 - 7.1e-05 22.3 2.5 0.03 13.7 0.9 2.6 2 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO09815.1 - 0.00014 20.6 1.6 0.88 8.1 0.0 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Frtz PF11768.8 ETO09815.1 - 0.00015 20.3 0.4 0.004 15.5 0.0 2.3 3 0 0 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETO09815.1 - 0.016 14.0 2.9 3.2 6.4 0.0 2.9 1 1 1 2 2 2 0 Nup133 N terminal like DUF5570 PF17731.1 ETO09815.1 - 0.027 14.6 0.8 0.71 10.0 0.1 2.9 1 1 2 3 3 3 0 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO09815.1 - 0.037 13.4 0.6 1.6 8.0 0.3 2.8 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO09815.1 - 0.048 12.2 0.5 1.7 7.1 0.0 2.8 3 1 1 4 4 4 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO09815.1 - 0.14 12.1 6.9 14 5.7 0.0 4.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO09816.1 - 7.3e-47 156.4 14.2 2e-08 34.7 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09816.1 - 1e-16 61.0 2.5 0.036 14.4 0.0 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09816.1 - 1e-07 31.3 2.0 0.13 11.2 0.1 4.6 1 1 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO09816.1 - 1e-05 24.4 4.2 0.51 8.9 0.0 4.9 1 1 4 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09816.1 - 0.001 18.4 0.2 0.001 18.4 0.2 3.5 3 1 2 5 5 5 2 WD40-like domain PALB2_WD40 PF16756.5 ETO09816.1 - 0.0013 17.7 0.6 0.7 8.7 0.1 3.5 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO09816.1 - 0.0021 18.0 2.3 6.2 6.9 0.0 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Me-amine-dh_H PF06433.11 ETO09816.1 - 0.0068 15.3 0.1 0.33 9.8 0.0 2.7 1 1 3 4 4 4 2 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO09816.1 - 0.032 12.8 0.4 0.2 10.1 0.1 2.2 1 1 1 2 2 2 0 Cytochrome D1 heme domain Ras PF00071.22 ETO09817.1 - 2.2e-39 134.7 0.3 4e-38 130.5 0.3 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO09817.1 - 3.5e-16 59.5 0.0 1.1e-15 57.9 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO09817.1 - 0.00016 21.2 0.1 0.00028 20.4 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO09817.1 - 0.0097 16.0 0.0 0.021 14.9 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF4201 PF13870.6 ETO09818.1 - 0.00036 20.3 18.5 0.00036 20.3 18.5 6.9 3 2 2 6 6 6 1 Domain of unknown function (DUF4201) DivIC PF04977.15 ETO09818.1 - 0.002 17.9 0.2 0.002 17.9 0.2 9.6 5 4 5 11 11 11 5 Septum formation initiator IFT57 PF10498.9 ETO09818.1 - 0.0032 16.5 15.7 0.0032 16.5 15.7 4.6 2 1 2 4 4 4 1 Intra-flagellar transport protein 57 CALCOCO1 PF07888.11 ETO09818.1 - 0.0078 15.1 7.1 0.0078 15.1 7.1 4.2 3 1 1 4 4 4 3 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-F_leu_zip PF10473.9 ETO09818.1 - 0.0082 16.2 16.7 0.0082 16.2 16.7 6.5 3 2 1 5 5 5 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ERM PF00769.19 ETO09818.1 - 0.009 15.9 16.1 0.009 15.9 16.1 5.1 3 1 2 5 5 5 4 Ezrin/radixin/moesin family Taxilin PF09728.9 ETO09818.1 - 0.67 9.1 89.0 0.17 11.0 53.3 4.9 3 1 0 3 3 3 0 Myosin-like coiled-coil protein Fez1 PF06818.15 ETO09818.1 - 0.94 9.9 79.5 0.54 10.7 13.2 5.0 1 1 4 5 5 5 0 Fez1 DUF2208 PF09973.9 ETO09818.1 - 1.6 8.3 7.3 4.6 6.8 2.7 2.6 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Kelch_6 PF13964.6 ETO09819.1 - 8.4e-08 32.2 3.8 0.00054 20.1 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO09819.1 - 0.00011 21.7 6.2 0.0047 16.5 0.4 4.2 4 1 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO09819.1 - 0.0019 18.1 3.7 1.3 9.1 0.7 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO09819.1 - 0.017 15.1 1.5 0.18 11.8 0.1 3.1 3 1 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO09819.1 - 0.51 10.4 6.3 13 6.0 0.3 4.2 5 1 0 5 5 5 0 Kelch motif BAF1_ABF1 PF04684.13 ETO09820.1 - 0.003 16.7 17.5 0.0035 16.5 17.5 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor SLC12 PF03522.15 ETO09820.1 - 0.74 8.8 12.3 0.89 8.5 12.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MCM_bind PF09739.9 ETO09820.1 - 2.5 6.5 15.3 3.1 6.1 15.3 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor FAM60A PF15396.6 ETO09820.1 - 3 7.8 9.4 3.8 7.4 9.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ETO09820.1 - 4.2 6.0 13.3 4.8 5.8 13.3 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO09820.1 - 5.2 5.7 12.7 5.5 5.7 12.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 ETO09820.1 - 6.4 5.2 19.9 7.1 5.1 19.9 1.0 1 0 0 1 1 1 0 Macoilin family PARG_cat PF05028.14 ETO09821.1 - 1.8e-36 126.1 7.9 2.3e-36 125.8 7.9 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PDDEXK_9 PF08011.11 ETO09821.1 - 0.18 11.7 5.5 0.52 10.2 5.5 1.7 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily DUF2207 PF09972.9 ETO09822.1 - 0.21 10.3 7.9 0.22 10.2 2.3 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF3674 PF12426.8 ETO09825.1 - 0.068 13.2 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 RNA dependent RNA polymerase NRIP1_repr_4 PF15690.5 ETO09826.1 - 0.0052 16.1 4.9 0.0062 15.9 4.9 1.0 1 0 0 1 1 1 1 Nuclear receptor-interacting protein 1 repression 4 adh_short PF00106.25 ETO09828.1 - 2.3e-23 82.7 0.5 2.2e-15 56.6 0.1 3.1 2 1 1 3 3 3 3 short chain dehydrogenase adh_short_C2 PF13561.6 ETO09828.1 - 5.2e-19 68.7 0.8 2.5e-14 53.4 0.1 3.0 2 1 1 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO09828.1 - 2e-06 27.8 0.0 3.7e-06 27.0 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO09828.1 - 0.00046 19.4 0.0 0.0007 18.8 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ETO09828.1 - 0.0014 17.7 0.1 0.0023 17.0 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO09828.1 - 0.0023 17.4 0.0 0.0051 16.3 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_Gly3P_dh_N PF01210.23 ETO09828.1 - 0.017 15.1 0.0 0.027 14.4 0.0 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DUF2368 PF10166.9 ETO09828.1 - 0.13 11.9 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) EF-hand_8 PF13833.6 ETO09829.1 - 0.018 14.9 0.7 0.037 13.9 0.7 1.6 1 0 0 1 1 1 0 EF-hand domain pair Phage_int_SAM_5 PF13102.6 ETO09830.1 - 0.0041 17.4 2.9 0.013 15.8 2.9 1.9 1 0 0 1 1 1 1 Phage integrase SAM-like domain NUC PF18510.1 ETO09830.1 - 0.64 10.5 12.7 8.2 6.8 12.7 2.2 1 1 0 1 1 1 0 Nuclease domain DUF1515 PF07439.11 ETO09831.1 - 0.00062 19.8 2.2 0.00062 19.8 2.2 2.9 3 1 0 3 3 3 1 Protein of unknown function (DUF1515) Trans_reg_C PF00486.28 ETO09831.1 - 0.2 11.8 1.8 0.56 10.3 0.1 2.5 3 0 0 3 3 3 0 Transcriptional regulatory protein, C terminal FliT PF05400.13 ETO09831.1 - 0.54 11.1 6.2 1 10.2 0.0 3.2 1 1 1 3 3 3 0 Flagellar protein FliT YabA PF06156.13 ETO09831.1 - 0.59 10.8 20.0 0.46 11.2 4.3 4.0 3 1 1 4 4 4 0 Initiation control protein YabA WD40 PF00400.32 ETO09832.1 - 5.9e-39 131.4 28.0 2.1e-06 28.3 0.8 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO09832.1 - 7.3e-13 48.0 6.3 0.09 11.4 0.1 6.0 2 1 4 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09832.1 - 4.6e-09 36.4 3.2 1.2 9.4 0.0 6.0 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO09832.1 - 2.7e-07 31.2 1.3 8.9e-07 29.5 1.3 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger DUF2774 PF11242.8 ETO09832.1 - 0.29 11.4 3.0 0.54 10.5 3.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2774) Acyl-CoA_dh_N PF02771.16 ETO09833.1 - 1.3e-13 51.6 0.0 2.3e-13 50.8 0.0 1.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Stonin2_N PF12016.8 ETO09834.1 - 0.083 12.3 0.0 0.11 11.9 0.0 1.1 1 0 0 1 1 1 0 Stonin 2 OST3_OST6 PF04756.13 ETO09836.1 - 3.5e-36 125.1 0.0 4.2e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family DUF4234 PF14018.6 ETO09836.1 - 0.014 15.5 0.6 0.04 14.0 0.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4234) Thioredoxin PF00085.20 ETO09836.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin Kinesin PF00225.23 ETO09837.1 - 1.5e-15 57.0 0.3 1.6e-15 56.9 0.3 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO09837.1 - 2e-07 31.1 0.1 2.3e-07 30.9 0.1 1.1 1 0 0 1 1 1 1 Microtubule binding Ribosomal_S7e PF01251.18 ETO09837.1 - 0.002 17.9 0.0 0.0021 17.9 0.0 1.0 1 0 0 1 1 1 1 Ribosomal protein S7e Shisa PF13908.6 ETO09838.1 - 0.00058 20.2 1.5 0.00073 19.8 1.0 1.3 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator Spc7 PF08317.11 ETO09838.1 - 0.0021 17.0 11.7 0.0035 16.3 11.7 1.4 1 0 0 1 1 1 1 Spc7 kinetochore protein K-box PF01486.17 ETO09838.1 - 0.0097 16.1 4.3 0.0097 16.1 4.3 2.8 2 1 1 3 3 2 1 K-box region WEMBL PF05701.11 ETO09838.1 - 0.0099 14.6 7.8 0.013 14.2 7.8 1.1 1 0 0 1 1 1 1 Weak chloroplast movement under blue light GAS PF13851.6 ETO09838.1 - 0.01 15.2 14.3 0.085 12.2 14.5 2.1 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding ABC2_membrane_3 PF12698.7 ETO09838.1 - 0.012 14.7 0.0 0.02 14.0 0.0 1.4 1 0 0 1 1 1 0 ABC-2 family transporter protein Exonuc_VII_L PF02601.15 ETO09838.1 - 0.014 14.9 6.2 0.015 14.9 5.6 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF4446 PF14584.6 ETO09838.1 - 0.023 14.7 2.9 0.023 14.7 2.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) BRE1 PF08647.11 ETO09838.1 - 0.033 14.3 8.9 0.074 13.1 8.4 1.9 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase HrpB7 PF09486.10 ETO09838.1 - 0.045 14.1 6.4 0.088 13.2 6.4 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF745 PF05335.13 ETO09838.1 - 0.076 12.7 7.1 0.094 12.4 3.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF2203 PF09969.9 ETO09838.1 - 0.09 13.5 2.5 0.22 12.3 2.5 1.7 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Laminin_I PF06008.14 ETO09838.1 - 0.13 11.9 12.3 0.5 10.0 12.3 1.9 1 1 0 1 1 1 0 Laminin Domain I Rootletin PF15035.6 ETO09838.1 - 0.14 12.2 16.6 0.11 12.5 13.4 2.0 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Phage_GP20 PF06810.11 ETO09838.1 - 0.26 11.1 7.7 0.31 10.8 5.9 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 APG6_N PF17675.1 ETO09838.1 - 0.37 11.3 14.7 0.79 10.3 14.7 1.5 1 0 0 1 1 1 0 Apg6 coiled-coil region Laminin_II PF06009.12 ETO09838.1 - 0.42 10.6 6.5 1.2 9.2 6.5 1.8 1 0 0 1 1 1 0 Laminin Domain II OmpH PF03938.14 ETO09838.1 - 0.48 10.8 7.0 1 9.7 7.0 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Atg14 PF10186.9 ETO09838.1 - 0.72 8.9 7.2 1.3 8.1 6.9 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM76 PF16046.5 ETO09838.1 - 0.75 9.1 7.6 8.5 5.6 6.7 2.0 2 0 0 2 2 2 0 FAM76 protein Ntox28 PF15605.6 ETO09838.1 - 0.89 9.8 4.9 1.8 8.8 0.8 2.8 2 1 1 3 3 3 0 Bacterial toxin 28 NPV_P10 PF05531.12 ETO09838.1 - 1.2 9.7 4.5 6.4 7.3 0.3 2.6 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein YabA PF06156.13 ETO09838.1 - 1.3 9.7 13.7 0.46 11.2 1.5 2.7 2 1 1 3 3 2 0 Initiation control protein YabA HemX PF04375.14 ETO09838.1 - 1.4 8.1 9.7 1.9 7.7 9.3 1.5 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FlxA PF14282.6 ETO09838.1 - 1.8 8.6 10.5 3.1 7.9 9.5 2.0 1 1 1 2 2 2 0 FlxA-like protein DUF4515 PF14988.6 ETO09838.1 - 2.1 8.2 18.5 0.048 13.5 2.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4515) FliJ PF02050.16 ETO09838.1 - 2.1 8.6 14.0 1.1 9.5 3.7 2.4 1 1 1 2 2 2 0 Flagellar FliJ protein GrpE PF01025.19 ETO09838.1 - 5 6.8 10.6 35 4.0 10.6 2.2 1 1 0 1 1 1 0 GrpE V_ATPase_I PF01496.19 ETO09838.1 - 6 4.6 11.1 1.7 6.5 8.4 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family DHR10 PF18595.1 ETO09838.1 - 6.6 6.8 17.0 89 3.2 4.6 2.7 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain FlaC_arch PF05377.11 ETO09838.1 - 7.3 7.1 10.4 9.5 6.7 2.1 3.3 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) Csm1_N PF18504.1 ETO09838.1 - 7.7 6.9 15.0 7.5 7.0 3.0 3.9 2 1 2 4 4 4 0 Csm1 N-terminal domain HIP1_clath_bdg PF16515.5 ETO09838.1 - 7.8 7.2 17.0 2.9 8.5 4.2 2.7 2 1 1 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PRKG1_interact PF15898.5 ETO09838.1 - 8 7.4 17.3 20 6.1 12.3 3.0 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain LapA_dom PF06305.11 ETO09838.1 - 8.8 6.2 7.2 19 5.1 0.0 3.2 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Kelch_4 PF13418.6 ETO09840.1 - 0.013 15.5 0.0 0.097 12.7 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO09840.1 - 0.075 13.3 0.2 11 6.5 0.0 3.5 4 0 0 4 4 4 0 Kelch motif SeqA_N PF17206.3 ETO09840.1 - 0.12 11.7 0.2 0.75 9.2 0.0 2.3 2 0 0 2 2 2 0 SeqA protein N-terminal domain ubiquitin PF00240.23 ETO09841.1 - 1.6e-26 91.8 0.6 2.6e-26 91.2 0.6 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO09841.1 - 5e-10 39.1 0.5 5e-10 39.1 0.5 1.7 2 0 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO09841.1 - 0.00053 20.4 0.3 0.0029 18.0 0.3 2.0 1 1 0 1 1 1 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO09841.1 - 0.049 13.7 0.1 0.19 11.8 0.0 2.0 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO09841.1 - 0.07 13.5 1.4 0.088 13.2 0.2 1.7 1 1 1 2 2 2 0 Ubiquitin-like domain MCM_bind PF09739.9 ETO09845.1 - 0.056 11.9 10.0 0.07 11.6 10.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor OATP PF03137.20 ETO09845.1 - 0.19 9.9 5.4 0.22 9.8 5.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family CDC45 PF02724.14 ETO09845.1 - 0.38 9.0 8.4 0.37 9.0 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ETO09845.1 - 1.2 7.8 11.1 1.3 7.7 11.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO09845.1 - 1.3 7.7 6.4 1.4 7.6 6.4 1.2 1 0 0 1 1 1 0 Presenilin Ureide_permease PF07168.11 ETO09845.1 - 1.7 7.3 7.0 2 7.1 7.0 1.1 1 0 0 1 1 1 0 Ureide permease PPL5 PF18168.1 ETO09845.1 - 1.8 7.8 8.1 2.2 7.5 8.1 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Connexin PF00029.19 ETO09845.1 - 1.8 8.3 11.6 2.5 7.8 11.6 1.2 1 0 0 1 1 1 0 Connexin AF-4 PF05110.13 ETO09845.1 - 2.3 6.2 19.0 2.4 6.1 19.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RR_TM4-6 PF06459.12 ETO09845.1 - 3.3 7.5 16.1 5 6.9 16.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EIIBC-GUT_N PF03612.14 ETO09845.1 - 6.1 6.5 8.4 9.4 5.9 8.4 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TMPIT PF07851.13 ETO09845.1 - 7.7 5.7 8.4 8.1 5.6 8.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein Afi1 PF07792.12 ETO09845.1 - 8.3 6.9 10.2 4.2 7.9 7.9 1.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CLN3 PF02487.17 ETO09845.1 - 9.9 5.1 6.3 12 4.8 6.3 1.2 1 0 0 1 1 1 0 CLN3 protein Sigma70_r1_1 PF03979.14 ETO09846.1 - 0.073 13.1 0.2 0.19 11.8 0.2 1.6 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 Peptidase_S10 PF00450.22 ETO09847.1 - 4.8e-28 98.7 2.9 1.2e-27 97.4 2.9 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase LEF-8 PF04941.12 ETO09847.1 - 0.015 13.6 0.8 0.018 13.3 0.8 1.0 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) EGF_2 PF07974.13 ETO09848.1 - 0.023 15.1 1.3 0.023 15.1 1.3 2.2 2 0 0 2 2 2 0 EGF-like domain TRP PF06011.12 ETO09848.1 - 0.036 12.8 0.0 0.053 12.2 0.0 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3377 PF11857.8 ETO09848.1 - 0.075 13.0 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Laminin_EGF PF00053.24 ETO09848.1 - 0.4 10.9 4.8 0.38 10.9 0.3 2.5 2 0 0 2 2 2 0 Laminin EGF domain SH3-WW_linker PF16618.5 ETO09849.1 - 0.067 13.7 1.5 0.086 13.3 0.8 1.5 1 1 1 2 2 2 0 Linker region between SH3 and WW domains on ARHGAP12 TMPIT PF07851.13 ETO09850.1 - 4.3e-27 95.2 16.2 4.3e-27 95.2 16.2 2.0 2 1 0 2 2 2 1 TMPIT-like protein MASE3 PF17159.4 ETO09850.1 - 0.013 15.2 5.4 0.013 15.2 4.0 1.6 2 0 0 2 2 2 0 Membrane-associated sensor domain tRNA_U5-meth_tr PF05958.11 ETO09850.1 - 0.017 14.2 0.8 0.029 13.4 0.8 1.4 1 0 0 1 1 1 0 tRNA (Uracil-5-)-methyltransferase CspB_prodomain PF18425.1 ETO09851.1 - 0.017 15.1 0.3 0.39 10.7 0.0 2.6 3 0 0 3 3 3 0 Csp protease B prodomain Cadherin_C_2 PF16492.5 ETO09852.1 - 0.044 14.5 1.4 0.15 12.8 0.0 2.4 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal DUF2442 PF10387.9 ETO09852.1 - 0.054 13.8 0.0 0.091 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2442) DUF3464 PF11947.8 ETO09853.1 - 0.016 15.0 0.6 0.029 14.1 0.6 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 LicD PF04991.13 ETO09853.1 - 0.25 11.4 11.3 0.41 10.7 5.0 2.5 2 0 0 2 2 2 0 LicD family Ctf8 PF09696.10 ETO09853.1 - 0.64 10.4 6.3 1.6 9.0 6.3 1.7 1 0 0 1 1 1 0 Ctf8 MAP17 PF15807.5 ETO09853.1 - 6.8 6.9 8.0 1.1 9.5 2.5 2.2 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Fer4_NifH PF00142.18 ETO09854.1 - 0.028 13.9 0.2 0.047 13.1 0.2 1.4 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family AA_permease_C PF13906.6 ETO09854.1 - 0.28 11.3 2.0 0.35 11.0 0.1 2.2 2 0 0 2 2 2 0 C-terminus of AA_permease PUB PF09409.10 ETO09856.1 - 0.00027 20.8 0.4 0.00079 19.3 0.4 1.8 1 1 0 1 1 1 1 PUB domain HIP1_clath_bdg PF16515.5 ETO09857.1 - 0.00015 22.3 1.1 0.00021 21.8 1.1 1.1 1 0 0 1 1 1 1 Clathrin-binding domain of Huntingtin-interacting protein 1 Prominin PF05478.11 ETO09857.1 - 0.00082 17.5 0.6 0.00082 17.5 0.6 1.4 2 0 0 2 2 2 1 Prominin APG6_N PF17675.1 ETO09857.1 - 0.0022 18.6 2.5 0.0027 18.2 2.5 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region Spc7 PF08317.11 ETO09857.1 - 0.0028 16.6 4.9 0.0033 16.3 4.9 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF16 PF01519.16 ETO09857.1 - 0.0071 16.8 0.8 0.0087 16.5 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF16 EzrA PF06160.12 ETO09857.1 - 0.0096 14.1 5.4 0.013 13.7 5.4 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Not3 PF04065.15 ETO09857.1 - 0.017 14.5 3.0 0.022 14.2 3.0 1.1 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component BLOC1_2 PF10046.9 ETO09857.1 - 0.025 14.9 5.3 0.037 14.3 5.3 1.3 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Syntaxin_2 PF14523.6 ETO09857.1 - 0.028 14.8 3.7 0.037 14.4 3.7 1.1 1 0 0 1 1 1 0 Syntaxin-like protein DUF4200 PF13863.6 ETO09857.1 - 0.031 14.7 6.3 0.041 14.3 6.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) NPV_P10 PF05531.12 ETO09857.1 - 0.04 14.4 2.7 0.091 13.2 2.7 1.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein ApoL PF05461.11 ETO09857.1 - 0.086 12.2 2.1 0.12 11.6 2.1 1.2 1 0 0 1 1 1 0 Apolipoprotein L HemX PF04375.14 ETO09857.1 - 0.092 12.0 4.5 0.13 11.5 4.5 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase YqfD PF06898.11 ETO09857.1 - 0.095 11.5 2.3 0.13 11.1 2.3 1.1 1 0 0 1 1 1 0 Putative stage IV sporulation protein YqfD YgaB PF14182.6 ETO09857.1 - 0.1 13.0 6.0 0.2 12.0 5.6 1.6 1 1 1 2 2 2 0 YgaB-like protein Exonuc_VII_L PF02601.15 ETO09857.1 - 0.11 12.1 1.2 0.13 11.8 1.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MCU PF04678.13 ETO09857.1 - 0.11 12.6 1.4 0.13 12.3 1.4 1.1 1 0 0 1 1 1 0 Mitochondrial calcium uniporter DUF3552 PF12072.8 ETO09857.1 - 0.18 11.2 8.8 0.64 9.4 8.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Muted PF14942.6 ETO09857.1 - 0.19 12.1 5.6 0.24 11.7 5.6 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein Cep57_MT_bd PF06657.13 ETO09857.1 - 0.19 12.2 5.5 4.1 7.9 0.4 2.2 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF4349 PF14257.6 ETO09857.1 - 0.22 10.9 4.5 0.2 11.1 2.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) FlaC_arch PF05377.11 ETO09857.1 - 0.41 11.1 2.7 0.79 10.2 2.2 1.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 ETO09857.1 - 0.8 9.5 5.4 0.87 9.4 4.0 1.7 1 1 1 2 2 2 0 Septum formation initiator Fzo_mitofusin PF04799.13 ETO09857.1 - 5.1 6.6 8.6 23 4.5 8.6 1.9 1 1 0 1 1 1 0 fzo-like conserved region Peptidase_M22 PF00814.25 ETO09858.1 - 0.019 14.7 0.0 0.024 14.4 0.0 1.1 1 0 0 1 1 1 0 Glycoprotease family BcrAD_BadFG PF01869.20 ETO09858.1 - 0.023 14.2 0.0 0.029 13.9 0.0 1.1 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DUF1836 PF08876.11 ETO09858.1 - 1.7 8.7 6.2 0.41 10.7 1.5 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF1836) Glyco_trans_4_5 PF16994.5 ETO09859.1 - 0.032 13.8 1.2 0.047 13.3 1.2 1.3 1 0 0 1 1 1 0 Glycosyl-transferase family 4 WD40 PF00400.32 ETO09860.1 - 4.4e-40 134.9 18.1 1.1e-06 29.3 0.1 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09860.1 - 2.8e-13 50.0 4.7 0.067 13.5 0.0 6.4 3 3 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09860.1 - 1.5e-08 33.7 6.4 1 7.9 0.0 5.4 2 2 3 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09860.1 - 5.7e-08 32.4 11.9 0.0005 19.5 1.2 4.0 3 2 2 5 5 5 3 WD40-like domain USP7_C2 PF14533.6 ETO09860.1 - 0.034 13.8 0.5 3.1 7.4 0.0 3.1 2 1 1 3 3 3 0 Ubiquitin-specific protease C-terminal UPF0220 PF05255.11 ETO09861.1 - 0.09 12.3 4.3 0.54 9.8 0.1 3.0 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0220) NAM-associated PF14303.6 ETO09862.1 - 0.0086 16.8 25.8 0.011 16.5 25.8 1.1 1 0 0 1 1 1 1 No apical meristem-associated C-terminal domain Merozoite_SPAM PF07133.11 ETO09862.1 - 0.041 13.9 30.4 0.063 13.3 30.4 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) NPR3 PF03666.13 ETO09862.1 - 0.88 8.3 21.9 1 8.1 21.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO09862.1 - 1.5 7.9 12.8 2.1 7.5 12.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO09862.1 - 1.9 6.7 29.3 2.2 6.5 29.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S64 PF08192.11 ETO09862.1 - 4.5 5.6 18.5 5.1 5.4 18.5 1.0 1 0 0 1 1 1 0 Peptidase family S64 PepSY_TM PF03929.16 ETO09862.1 - 5.7 6.5 6.3 7.6 6.1 6.3 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Gcd10p PF04189.13 ETO09862.1 - 7 5.7 19.3 8.2 5.4 19.3 1.1 1 0 0 1 1 1 0 Gcd10p family LAP1C PF05609.12 ETO09862.1 - 8.5 5.3 25.1 9.2 5.2 25.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF1968 PF09291.10 ETO09863.1 - 0.00084 19.3 3.3 0.024 14.7 0.1 2.3 2 1 0 2 2 2 2 Domain of unknown function (DUF1968) Jak1_Phl PF17887.1 ETO09863.1 - 0.22 11.5 14.5 0.25 11.3 0.2 3.0 1 1 2 3 3 3 0 Jak1 pleckstrin homology-like domain DUF1846 PF08903.11 ETO09864.1 - 0.0072 14.9 0.8 0.0085 14.7 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1846) AAA_12 PF13087.6 ETO09866.1 - 4.8e-56 189.5 0.1 9.9e-56 188.5 0.0 1.5 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ETO09866.1 - 6.6e-43 147.4 2.5 1.6e-22 80.6 0.2 2.4 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 ETO09866.1 - 2.1e-15 57.3 0.1 3.7e-14 53.3 0.1 2.3 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETO09866.1 - 3.9e-15 56.1 0.0 1e-14 54.7 0.0 1.7 1 1 0 1 1 1 1 AAA domain UvrD-helicase PF00580.21 ETO09866.1 - 2.4e-08 33.8 0.0 1.3e-05 24.9 0.0 2.5 1 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain PhoH PF02562.16 ETO09866.1 - 5.7e-06 25.9 0.1 0.0022 17.5 0.1 2.3 2 0 0 2 2 2 1 PhoH-like protein AAA_22 PF13401.6 ETO09866.1 - 2e-05 24.9 0.0 0.00093 19.5 0.0 2.7 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ETO09866.1 - 0.00019 21.3 0.0 2.3 7.9 0.0 3.3 2 1 1 3 3 3 1 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ETO09866.1 - 0.00026 20.3 0.7 0.0062 15.8 0.1 2.9 2 1 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 ETO09866.1 - 0.0007 20.0 0.1 0.002 18.6 0.0 2.0 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) DEAD PF00270.29 ETO09866.1 - 0.0014 18.5 0.0 0.0058 16.4 0.0 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase PIF1 PF05970.14 ETO09866.1 - 0.0016 17.7 0.4 0.019 14.1 0.4 2.3 1 1 0 1 1 1 1 PIF1-like helicase DnaB_C PF03796.15 ETO09866.1 - 0.0021 17.4 0.1 0.0047 16.3 0.1 1.6 1 0 0 1 1 1 1 DnaB-like helicase C terminal domain Sigma54_activat PF00158.26 ETO09866.1 - 0.0032 17.2 0.1 0.0083 15.8 0.1 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 ETO09866.1 - 0.0038 17.6 0.0 0.012 16.0 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain ResIII PF04851.15 ETO09866.1 - 0.0044 17.0 3.3 0.02 14.9 0.5 3.0 2 1 1 3 3 3 1 Type III restriction enzyme, res subunit Helicase_RecD PF05127.14 ETO09866.1 - 0.019 14.8 0.0 0.058 13.3 0.0 1.8 1 0 0 1 1 1 0 Helicase AAA_7 PF12775.7 ETO09866.1 - 0.031 13.8 0.1 0.064 12.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region T2SSE PF00437.20 ETO09866.1 - 0.033 13.2 0.1 0.061 12.4 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_18 PF13238.6 ETO09866.1 - 0.039 14.5 0.0 0.16 12.5 0.0 2.1 2 1 1 3 3 1 0 AAA domain IstB_IS21 PF01695.17 ETO09866.1 - 0.049 13.4 0.0 0.2 11.3 0.0 2.0 2 0 0 2 2 2 0 IstB-like ATP binding protein RuvB_N PF05496.12 ETO09866.1 - 0.055 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO09866.1 - 0.063 13.3 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETO09866.1 - 0.066 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_33 PF13671.6 ETO09866.1 - 0.069 13.3 0.0 0.19 11.9 0.0 1.9 1 0 0 1 1 1 0 AAA domain fn1 PF00039.18 ETO09866.1 - 0.098 12.9 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Fibronectin type I domain AAA_24 PF13479.6 ETO09866.1 - 0.11 12.2 0.0 0.33 10.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain EF-hand_7 PF13499.6 ETO09867.1 - 7e-11 42.4 10.8 1.2e-07 32.1 1.1 2.8 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO09867.1 - 1e-09 37.5 2.1 1.3e-05 24.8 0.3 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO09867.1 - 2.8e-08 32.7 6.0 2.6e-06 26.5 0.2 3.2 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO09867.1 - 2.9e-05 23.8 2.5 0.0035 17.2 0.4 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO09867.1 - 5.1e-05 22.6 1.4 0.00042 19.7 0.2 2.4 2 0 0 2 2 2 1 EF hand Cauli_DNA-bind PF03310.13 ETO09867.1 - 0.0089 16.1 1.1 0.034 14.2 1.1 1.9 2 0 0 2 2 2 1 Caulimovirus DNA-binding protein UAA PF08449.11 ETO09868.1 - 1.3e-41 142.8 22.7 1.1e-40 139.8 15.5 2.1 2 0 0 2 2 2 2 UAA transporter family OMP_b-brl_2 PF13568.6 ETO09868.1 - 0.063 13.3 0.5 0.15 12.1 0.2 1.7 2 0 0 2 2 2 0 Outer membrane protein beta-barrel domain V-ATPase_C PF03223.15 ETO09869.1 - 2.9e-124 415.3 4.4 3.3e-124 415.1 4.4 1.0 1 0 0 1 1 1 1 V-ATPase subunit C MRNIP PF15749.5 ETO09869.1 - 0.17 12.6 14.1 0.2 12.4 0.7 2.8 2 0 0 2 2 2 0 MRN-interacting protein Zip PF02535.22 ETO09869.1 - 1.4 8.1 5.1 1.7 7.8 5.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RNase_H_2 PF13482.6 ETO09869.1 - 5.1 7.1 6.9 2.7 7.9 0.1 2.7 3 0 0 3 3 3 0 RNase_H superfamily SPX PF03105.19 ETO09870.1 - 1.7e-15 57.8 30.7 3.1e-10 40.5 4.8 3.1 1 1 1 2 2 2 2 SPX domain Asp2 PF16929.5 ETO09870.1 - 0.078 11.9 11.1 0.087 11.8 11.1 1.2 1 0 0 1 1 1 0 Accessory Sec system GspB-transporter QVR PF17064.5 ETO09870.1 - 0.45 10.8 0.1 0.45 10.8 0.1 2.2 2 1 0 2 2 2 0 Sleepless protein CCDC106 PF15794.5 ETO09872.1 - 2.2 8.0 10.4 0.28 10.8 1.2 2.0 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 UBA_4 PF14555.6 ETO09873.1 - 1.2e-07 31.4 0.0 2.2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ETO09873.1 - 0.012 15.2 0.1 0.11 12.2 0.0 2.3 2 0 0 2 2 2 0 TAP C-terminal domain Rad50_zn_hook PF04423.14 ETO09873.1 - 0.1 12.4 2.1 0.36 10.7 2.1 2.0 1 0 0 1 1 1 0 Rad50 zinc hook motif DUF4258 PF14076.6 ETO09874.1 - 0.014 15.8 0.2 7.9 6.9 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4258) SAM_1 PF00536.30 ETO09874.1 - 0.099 13.1 0.1 0.19 12.2 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO09874.1 - 0.12 12.5 0.0 0.27 11.4 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF1108 PF06531.11 ETO09875.1 - 0.036 14.4 0.1 0.059 13.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1108) Ureide_permease PF07168.11 ETO09875.1 - 9.7 4.8 7.6 4.2 6.0 5.6 1.4 1 1 0 1 1 1 0 Ureide permease PRKG1_interact PF15898.5 ETO09876.1 - 0.8 10.6 13.1 0.25 12.2 9.5 1.9 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF4407 PF14362.6 ETO09876.1 - 1.2 8.5 8.2 1.8 7.9 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vps52 PF04129.12 ETO09877.1 - 5e-26 91.5 3.3 7.2e-26 91.0 3.3 1.1 1 0 0 1 1 1 1 Vps52 / Sac2 family Sec3_C PF09763.9 ETO09877.1 - 1e-07 30.8 6.0 1.4e-07 30.3 6.0 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec3 HMMR_N PF15905.5 ETO09877.1 - 0.0037 16.8 6.8 0.0037 16.8 6.8 1.6 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal COG4 PF08318.12 ETO09877.1 - 0.005 16.0 2.3 0.0069 15.5 2.3 1.1 1 0 0 1 1 1 1 COG4 transport protein IFT57 PF10498.9 ETO09877.1 - 0.0064 15.5 8.6 0.0064 15.5 8.6 1.3 1 1 0 1 1 1 1 Intra-flagellar transport protein 57 Laminin_II PF06009.12 ETO09877.1 - 0.0077 16.2 4.4 0.0095 15.9 1.3 2.2 1 1 1 2 2 2 1 Laminin Domain II COG2 PF06148.11 ETO09877.1 - 0.012 15.7 6.9 0.12 12.5 6.9 2.2 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 ApoB100_C PF12491.8 ETO09877.1 - 0.014 15.3 1.3 0.014 15.3 1.3 2.8 3 0 0 3 3 3 0 Apolipoprotein B100 C terminal Spc7 PF08317.11 ETO09877.1 - 0.017 14.0 4.5 0.021 13.7 4.5 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF812 PF05667.11 ETO09877.1 - 0.026 13.4 8.2 0.031 13.2 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MscS_porin PF12795.7 ETO09877.1 - 0.063 12.8 2.5 0.069 12.7 1.8 1.5 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain COG5 PF10392.9 ETO09877.1 - 0.079 13.1 7.5 0.093 12.9 6.5 1.6 1 1 1 2 2 2 0 Golgi transport complex subunit 5 DnaG_DnaB_bind PF08278.11 ETO09877.1 - 0.14 12.8 2.0 0.81 10.3 0.1 2.3 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding DUF1664 PF07889.12 ETO09877.1 - 0.49 10.4 5.9 0.46 10.5 3.3 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) D123 PF07065.14 ETO09878.1 - 0.17 11.0 2.3 0.12 11.5 0.2 1.8 2 0 0 2 2 2 0 D123 PUB PF09409.10 ETO09880.1 - 0.014 15.3 0.9 0.092 12.7 0.9 2.3 1 1 0 1 1 1 0 PUB domain BORCS6 PF10157.9 ETO09880.1 - 0.11 12.8 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 Ku_N PF03731.15 ETO09881.1 - 0.048 13.4 0.1 0.088 12.5 0.1 1.4 1 0 0 1 1 1 0 Ku70/Ku80 N-terminal alpha/beta domain Ank PF00023.30 ETO09882.1 - 1.7e-13 50.4 0.1 4.7e-09 36.3 0.1 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 ETO09882.1 - 1e-11 45.2 0.0 5.8e-10 39.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO09882.1 - 2.3e-11 42.9 0.2 1.3e-05 25.2 0.0 4.8 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ETO09882.1 - 6.4e-10 39.4 0.0 6.3e-05 23.5 0.0 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO09882.1 - 5.3e-08 33.0 0.0 3.9e-07 30.2 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (many copies) DUF2179 PF10035.9 ETO09883.1 - 0.082 12.7 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2179) DcpS_C PF11969.8 ETO09884.1 - 1.8e-16 60.6 0.5 3.9e-09 37.0 0.2 2.6 2 0 0 2 2 2 2 Scavenger mRNA decapping enzyme C-term binding HIT PF01230.23 ETO09884.1 - 1.8e-12 47.8 0.9 6.6e-12 46.0 0.4 2.1 2 0 0 2 2 2 1 HIT domain zf-C2HE PF16278.5 ETO09884.1 - 1.7e-06 28.4 1.3 1.7e-06 28.4 1.3 2.5 2 0 0 2 2 2 1 C2HE / C2H2 / C2HC zinc-binding finger Atg14 PF10186.9 ETO09884.1 - 0.0004 19.6 0.6 0.0004 19.6 0.6 1.9 2 0 0 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 Mit_ribos_Mrp51 PF11709.8 ETO09885.1 - 0.056 13.0 3.6 0.065 12.8 3.6 1.1 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit CooC_C PF15976.5 ETO09886.1 - 0.041 13.9 0.0 0.082 13.0 0.0 1.5 1 0 0 1 1 1 0 CS1-pili formation C-terminal DUF1660 PF07874.11 ETO09886.1 - 0.053 14.0 0.6 0.36 11.4 0.2 2.5 3 0 0 3 3 3 0 Prophage protein (DUF1660) HEAT PF02985.22 ETO09888.1 - 0.0048 17.0 0.0 0.051 13.8 0.0 2.5 2 0 0 2 2 2 1 HEAT repeat Cnd1 PF12717.7 ETO09888.1 - 0.027 14.5 2.3 0.22 11.6 0.1 2.3 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO09888.1 - 0.16 12.5 0.0 0.3 11.6 0.0 1.5 1 0 0 1 1 1 0 HEAT-like repeat Med2 PF11214.8 ETO09891.1 - 0.042 14.0 1.2 0.1 12.7 0.1 2.0 2 0 0 2 2 2 0 Mediator complex subunit 2 WD40 PF00400.32 ETO09892.1 - 6.2e-50 166.1 10.4 9.1e-09 35.8 0.0 7.9 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09892.1 - 3.1e-16 59.4 3.8 0.0081 16.4 0.0 7.6 3 1 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09892.1 - 5.8e-12 45.2 1.1 0.072 12.0 0.0 5.8 2 2 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_5 PF13854.6 ETO09892.1 - 1.1e-09 38.0 5.9 0.00067 19.6 1.1 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO09892.1 - 4.5e-08 33.1 6.3 0.0022 18.2 0.2 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO09892.1 - 2.7e-07 30.1 9.0 0.00088 18.8 0.9 5.6 6 0 0 6 6 6 1 Kelch motif WD40_like PF17005.5 ETO09892.1 - 2e-05 24.1 1.1 0.37 10.1 0.0 4.5 3 1 3 6 6 6 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO09892.1 - 0.00019 20.1 0.3 0.0016 17.0 0.0 2.5 3 0 0 3 3 3 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO09892.1 - 0.00036 20.4 5.9 6 6.9 0.0 6.3 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO09892.1 - 0.0014 17.4 1.8 0.13 10.8 1.0 2.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Kelch_2 PF07646.15 ETO09892.1 - 0.0031 17.4 3.7 0.21 11.6 0.6 3.9 3 0 0 3 3 3 1 Kelch motif Methyltransf_3 PF01596.17 ETO09892.1 - 0.0039 16.4 0.0 0.15 11.3 0.0 2.7 2 1 1 3 3 3 1 O-methyltransferase SGL PF08450.12 ETO09892.1 - 0.0085 15.7 0.1 0.071 12.7 0.0 2.4 2 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Kelch_4 PF13418.6 ETO09892.1 - 0.01 15.8 2.3 1 9.4 0.1 4.2 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF4875 PF16175.5 ETO09892.1 - 0.037 14.1 0.2 5.5 7.2 0.0 3.6 2 1 1 4 4 4 0 Domain of unknown function (DUF4875) Proteasome_A_N PF10584.9 ETO09892.1 - 2.7 7.7 6.9 53 3.6 0.0 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature MFS_1 PF07690.16 ETO09893.1 - 0.00033 19.7 16.9 0.00033 19.7 16.9 2.8 2 1 1 3 3 3 3 Major Facilitator Superfamily DUF4359 PF14271.6 ETO09894.1 - 0.023 15.5 1.4 0.077 13.8 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4359) PUB PF09409.10 ETO09894.1 - 0.062 13.2 1.9 0.14 12.1 0.5 2.3 2 0 0 2 2 2 0 PUB domain Zip PF02535.22 ETO09895.1 - 2.2e-41 142.2 22.7 2.8e-27 95.8 9.6 2.0 1 1 1 2 2 2 2 ZIP Zinc transporter WD40 PF00400.32 ETO09896.1 - 2.4e-18 66.1 4.3 1e-05 26.2 0.0 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09896.1 - 3.8e-06 27.1 0.3 2.5 8.4 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09896.1 - 0.00012 20.9 0.3 0.28 9.8 0.2 2.7 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF5074 PF16819.5 ETO09896.1 - 0.025 14.6 0.0 0.037 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5074) Kelch_1 PF01344.25 ETO09897.1 - 1.3e-08 34.3 0.4 3.6e-05 23.3 0.1 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO09897.1 - 4.5e-06 26.6 0.1 0.013 15.5 0.1 2.9 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO09897.1 - 1e-05 25.6 1.6 0.11 12.9 0.1 3.4 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO09897.1 - 1.1e-05 25.5 0.0 0.0003 21.0 0.0 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO09897.1 - 0.00014 21.7 4.3 0.011 15.7 0.5 4.2 4 0 0 4 4 4 1 Kelch motif Methyltransf_FA PF12248.8 ETO09897.1 - 0.011 16.0 1.2 1.6 9.1 0.4 3.0 3 0 0 3 3 3 0 Farnesoic acid 0-methyl transferase DKNYY PF13644.6 ETO09897.1 - 0.035 14.9 2.1 0.085 13.6 2.1 1.6 1 1 0 1 1 1 0 DKNYY family XRN1_D2_D3 PF18334.1 ETO09899.1 - 0.022 15.0 0.0 0.063 13.5 0.0 1.8 1 0 0 1 1 1 0 Exoribonuclease Xrn1 D2/D3 domain MAGE_N PF12440.8 ETO09900.1 - 4.3 8.1 13.8 1.5 9.5 4.1 2.9 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Proteasome PF00227.26 ETO09902.1 - 2.2e-34 118.6 0.4 5.8e-31 107.5 0.4 3.1 1 1 0 1 1 1 1 Proteasome subunit SAP18 PF06487.12 ETO09902.1 - 0.16 12.1 0.1 0.34 11.1 0.0 1.6 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) UPF0542 PF15086.6 ETO09903.1 - 0.033 14.1 0.1 0.058 13.3 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 Agouti PF05039.12 ETO09903.1 - 2.1 9.1 4.7 3.3 8.5 1.2 2.2 1 1 1 2 2 2 0 Agouti protein HAD PF12710.7 ETO09904.1 - 0.0013 19.2 0.0 0.09 13.2 0.1 2.2 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase UvrD_C PF13361.6 ETO09904.1 - 0.012 15.0 1.0 0.018 14.5 1.0 1.3 1 0 0 1 1 1 0 UvrD-like helicase C-terminal domain DUF1517 PF07466.11 ETO09904.1 - 0.019 15.1 1.9 0.06 13.5 1.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1517) DUF1981 PF09324.10 ETO09904.1 - 0.021 14.7 0.2 0.26 11.2 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) Aspzincin_M35 PF14521.6 ETO09904.1 - 0.65 10.5 3.2 12 6.4 0.1 3.1 1 1 2 3 3 3 0 Lysine-specific metallo-endopeptidase DUF16 PF01519.16 ETO09904.1 - 0.66 10.5 5.9 1.5 9.3 4.7 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 RPEL PF02755.15 ETO09905.1 - 0.00018 21.1 7.5 0.23 11.2 0.0 4.1 3 1 0 3 3 3 2 RPEL repeat RNA_pol_3_Rpc31 PF11705.8 ETO09905.1 - 0.00045 20.5 13.7 0.00045 20.5 13.7 2.5 2 1 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 BSP_II PF05432.11 ETO09905.1 - 0.22 11.2 23.4 0.55 9.9 23.4 1.6 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) YlqD PF11068.8 ETO09905.1 - 0.38 11.1 14.2 0.28 11.6 9.5 2.6 2 0 0 2 2 2 0 YlqD protein Sporozoite_P67 PF05642.11 ETO09905.1 - 0.66 8.0 13.1 0.023 12.8 5.3 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen CENP-H PF05837.12 ETO09905.1 - 2.6 8.5 13.7 0.47 10.9 8.7 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Astro_capsid_p PF12226.8 ETO09905.1 - 3.9 6.5 15.2 7.3 5.6 15.2 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein FlaC_arch PF05377.11 ETO09905.1 - 5.7 7.4 8.2 2.9 8.3 1.1 3.1 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) CENP-B_dimeris PF09026.10 ETO09905.1 - 7.6 7.0 28.7 29 5.2 28.7 2.0 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO09905.1 - 7.8 4.5 29.3 14 3.6 29.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi FYVE PF01363.21 ETO09906.1 - 2.4e-08 34.0 14.3 5e-08 33.0 14.3 1.5 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ETO09906.1 - 0.00088 19.5 8.5 0.00088 19.5 8.5 2.0 2 0 0 2 2 2 1 FYVE-type zinc finger Siva PF05458.12 ETO09906.1 - 0.025 14.3 4.4 0.046 13.4 4.4 1.3 1 0 0 1 1 1 0 Cd27 binding protein (Siva) CLASP_N PF12348.8 ETO09907.1 - 1.1e-11 44.8 0.7 1.5e-11 44.3 0.7 1.2 1 0 0 1 1 1 1 CLASP N terminal DUF2894 PF11445.8 ETO09907.1 - 0.0087 16.6 3.8 0.015 15.8 3.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2894) DUF5327 PF17261.2 ETO09907.1 - 0.17 12.6 7.1 0.17 12.7 4.8 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5327) AAA_22 PF13401.6 ETO09907.1 - 0.19 12.0 2.5 0.31 11.3 0.2 2.1 1 1 0 2 2 2 0 AAA domain DUF1018 PF06252.12 ETO09907.1 - 1.2 10.1 9.0 4.6 8.2 0.0 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF1018) YkyA PF10368.9 ETO09909.1 - 0.05 13.3 0.2 0.05 13.3 0.2 2.2 3 0 0 3 3 3 0 Putative cell-wall binding lipoprotein Phage_terminase PF10668.9 ETO09909.1 - 0.15 12.1 0.2 0.3 11.1 0.2 1.5 1 0 0 1 1 1 0 Phage terminase small subunit EXS PF03124.14 ETO09910.1 - 3.2e-33 115.4 13.1 4.6e-33 115.0 13.1 1.2 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ETO09911.1 - 0.00022 21.3 3.2 0.00037 20.5 3.2 1.3 1 0 0 1 1 1 1 SPX domain SSFA2_C PF14723.6 ETO09911.1 - 0.012 15.5 0.0 0.053 13.4 0.0 1.9 1 1 1 2 2 2 0 Sperm-specific antigen 2 C-terminus DUF4491 PF14898.6 ETO09911.1 - 0.02 15.3 0.5 8.9 6.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4491) Propeptide_C1 PF08127.13 ETO09911.1 - 0.091 12.7 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Peptidase family C1 propeptide DUF1725 PF08333.11 ETO09911.1 - 0.1 12.3 0.0 0.22 11.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1725) SPX PF03105.19 ETO09912.1 - 4e-09 36.9 10.6 8.3e-09 35.8 10.6 1.5 1 1 0 1 1 1 1 SPX domain Band_3_cyto PF07565.13 ETO09912.1 - 0.059 13.2 5.2 0.071 12.9 5.2 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain NPAT_C PF15712.5 ETO09912.1 - 0.54 8.9 15.8 0.63 8.6 15.8 1.0 1 0 0 1 1 1 0 NPAT C terminus Acatn PF13000.7 ETO09912.1 - 0.55 8.7 3.8 0.38 9.2 2.6 1.3 1 1 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Zip PF02535.22 ETO09912.1 - 0.92 8.7 7.6 1.1 8.4 7.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 ETO09912.1 - 1.6 9.0 21.6 2.3 8.5 21.6 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Presenilin PF01080.17 ETO09912.1 - 1.8 7.2 9.6 2.2 6.9 9.6 1.1 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 ETO09912.1 - 2.3 7.9 13.8 15 5.3 13.8 1.9 1 1 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Ctr PF04145.15 ETO09912.1 - 3.8 8.1 4.5 13 6.4 4.5 1.8 1 1 0 1 1 1 0 Ctr copper transporter family Tubulin PF00091.25 ETO09913.1 - 4.3e-30 105.4 0.1 5.7e-30 105.0 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 ETO09913.1 - 0.11 12.8 0.3 0.26 11.6 0.2 1.7 1 1 1 2 2 2 0 Misato Segment II tubulin-like domain Tubulin_C PF03953.17 ETO09914.1 - 6.6e-25 87.7 0.0 1.1e-24 87.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO09914.1 - 2.7e-11 44.0 0.0 4.5e-11 43.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain RHH_3 PF12651.7 ETO09915.1 - 0.082 12.9 0.0 0.27 11.2 0.0 1.8 2 0 0 2 2 2 0 Ribbon-helix-helix domain HalX PF08663.10 ETO09915.1 - 0.26 11.6 2.1 1.6 9.1 1.1 2.4 2 1 0 2 2 2 0 HalX domain Lyase_1 PF00206.20 ETO09916.1 - 6.6e-101 337.8 0.6 2.5e-99 332.6 0.6 2.1 1 1 0 1 1 1 1 Lyase FumaraseC_C PF10415.9 ETO09916.1 - 2.6e-20 72.6 3.6 2.7e-15 56.5 1.0 2.6 2 0 0 2 2 2 2 Fumarase C C-terminus Adeno_E3_15_3 PF03307.14 ETO09917.1 - 0.021 14.7 0.2 1.8 8.5 0.1 2.1 2 0 0 2 2 2 0 Adenovirus 15.3kD protein in E3 region DUF3993 PF13158.6 ETO09917.1 - 0.12 12.6 1.1 0.4 10.9 0.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3993) NIF PF03031.18 ETO09918.1 - 1.9e-15 57.0 3.1 3.5e-07 30.1 0.2 3.5 3 0 0 3 3 3 3 NLI interacting factor-like phosphatase FERM_M PF00373.18 ETO09919.1 - 0.0041 17.5 0.2 0.013 15.9 0.2 1.8 1 1 0 1 1 1 1 FERM central domain DLIC PF05783.11 ETO09920.1 - 9.1e-16 57.7 0.6 8.6e-13 47.9 0.0 2.1 2 0 0 2 2 2 2 Dynein light intermediate chain (DLIC) ANAPC10 PF03256.16 ETO09920.1 - 0.12 12.0 0.2 0.22 11.2 0.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex, subunit 10 (APC10) MDFI PF15316.6 ETO09920.1 - 0.42 10.7 2.6 0.3 11.2 0.8 1.6 2 0 0 2 2 2 0 MyoD family inhibitor WD40 PF00400.32 ETO09922.1 - 1.3e-47 158.7 19.0 4.1e-08 33.8 0.2 7.8 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09922.1 - 6e-17 61.7 1.3 0.17 12.2 0.0 6.2 4 2 2 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09922.1 - 5.1e-15 55.1 7.5 0.00094 17.9 0.1 6.0 3 2 3 6 6 6 5 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO09922.1 - 2.4e-07 30.8 0.4 0.00089 19.2 0.1 3.5 2 2 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO09922.1 - 0.00091 18.3 2.8 0.56 9.1 0.1 3.5 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PPR_long PF17177.4 ETO09922.1 - 0.074 12.4 0.1 5.5 6.3 0.0 2.3 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP WD40 PF00400.32 ETO09924.1 - 3.3e-151 486.6 71.7 6e-10 39.6 1.1 16.7 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09924.1 - 2.9e-53 178.1 17.2 0.00033 20.9 0.0 15.2 1 1 14 15 15 15 14 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09924.1 - 4e-31 108.5 10.6 0.0063 15.9 0.1 9.9 3 3 3 8 8 8 8 WD40-like domain Ge1_WD40 PF16529.5 ETO09924.1 - 3.6e-18 65.6 11.2 0.89 8.4 0.0 13.2 2 1 13 15 15 15 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO09924.1 - 1.3e-08 35.0 0.0 2.9e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PD40 PF07676.12 ETO09924.1 - 1.2e-07 31.4 25.8 8.1 6.5 0.0 11.7 13 0 0 13 13 12 1 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO09924.1 - 0.00034 20.2 1.8 0.00067 19.3 1.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO09924.1 - 0.0005 20.6 0.2 0.0039 17.7 0.0 2.8 2 0 0 2 2 1 1 AAA domain HARP PF07443.13 ETO09924.1 - 0.0029 17.2 12.5 17 5.1 0.0 9.0 11 0 0 11 11 11 0 HepA-related protein (HARP) AAA_22 PF13401.6 ETO09924.1 - 0.005 17.1 0.0 0.021 15.1 0.0 2.1 1 0 0 1 1 1 1 AAA domain Cytochrom_D1 PF02239.16 ETO09924.1 - 0.019 13.5 12.9 3.4 6.1 0.1 5.7 4 3 0 6 6 6 0 Cytochrome D1 heme domain RNA_helicase PF00910.22 ETO09924.1 - 0.044 14.2 0.8 0.43 11.0 0.1 3.0 2 0 0 2 2 2 0 RNA helicase Sulfotransfer_4 PF17784.1 ETO09924.1 - 0.058 13.2 1.4 0.13 12.1 0.3 2.1 2 0 0 2 2 2 0 Sulfotransferase domain SH3_17 PF18350.1 ETO09924.1 - 0.069 13.0 0.0 13 5.7 0.0 2.8 2 0 0 2 2 2 0 Restriction endonuclease SH3 domain Pentapeptide_4 PF13599.6 ETO09924.1 - 0.17 12.1 5.3 0.03 14.5 1.1 1.9 2 0 0 2 2 1 0 Pentapeptide repeats (9 copies) ABC_tran PF00005.27 ETO09924.1 - 0.32 11.5 2.4 1.4 9.4 0.0 3.1 3 0 0 3 3 3 0 ABC transporter Nbas_N PF15492.6 ETO09924.1 - 1.5 8.1 21.2 5.8 6.2 0.2 7.5 3 3 6 10 10 10 0 Neuroblastoma-amplified sequence, N terminal WD40 PF00400.32 ETO09926.1 - 1.1e-41 140.0 33.1 3.9e-07 30.7 3.4 8.6 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09926.1 - 4.4e-14 52.6 2.9 0.042 14.1 0.1 5.6 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09926.1 - 3.8e-10 39.0 7.9 0.0023 16.6 0.1 5.7 2 2 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09926.1 - 1.5e-06 27.8 7.2 0.92 8.8 0.1 4.8 4 1 1 5 5 5 4 WD40-like domain zf-TRAF PF02176.18 ETO09926.1 - 9.8e-06 26.2 5.2 5.7e-05 23.7 5.2 2.5 1 0 0 1 1 1 1 TRAF-type zinc finger DUF1640 PF07798.11 ETO09926.1 - 0.17 11.9 5.5 0.31 11.1 5.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) Csm1_N PF18504.1 ETO09926.1 - 1.3 9.4 13.2 0.18 12.2 4.9 2.4 1 1 1 2 2 2 0 Csm1 N-terminal domain WD40 PF00400.32 ETO09928.1 - 1.4e-33 114.4 23.0 1.4e-06 28.9 1.4 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO09928.1 - 3.6e-13 49.0 4.8 0.001 17.8 0.1 5.0 1 1 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09928.1 - 3.6e-12 46.4 1.3 0.0098 16.2 0.0 4.9 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09928.1 - 0.00011 21.6 5.4 0.0034 16.7 0.3 3.5 1 1 2 4 4 4 1 WD40-like domain DUF4221 PF13970.6 ETO09928.1 - 0.0049 16.5 1.5 0.019 14.5 0.3 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4221) SH3_13 PF18335.1 ETO09928.1 - 0.019 14.7 2.6 0.2 11.5 0.5 2.8 3 1 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain KH_1 PF00013.29 ETO09929.1 - 5.5e-34 115.8 10.3 6.3e-11 41.9 0.1 4.2 3 1 0 3 3 3 3 KH domain KH_4 PF13083.6 ETO09929.1 - 0.00055 19.8 3.1 1.2 9.1 0.0 3.7 4 0 0 4 4 4 2 KH domain zf-4CXXC_R1 PF10497.9 ETO09929.1 - 0.025 14.8 0.3 0.067 13.4 0.3 1.7 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 TPR_10 PF13374.6 ETO09930.1 - 6.5e-06 25.8 0.0 1.9e-05 24.4 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO09930.1 - 2.7e-05 24.3 0.1 0.00035 20.8 0.0 2.2 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO09930.1 - 7e-05 22.6 0.1 0.00017 21.4 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO09930.1 - 0.00019 21.3 3.9 0.00049 20.0 3.3 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO09930.1 - 0.00032 20.7 4.3 0.0011 19.0 4.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO09930.1 - 0.0067 16.2 6.3 0.0094 15.7 4.8 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO09930.1 - 0.041 14.5 0.4 0.094 13.4 0.4 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat ATP-synt_F PF01990.17 ETO09930.1 - 0.043 14.1 5.3 0.086 13.2 0.4 2.3 1 1 1 2 2 2 0 ATP synthase (F/14-kDa) subunit Fis1_TPR_C PF14853.6 ETO09930.1 - 0.066 13.3 2.5 0.18 11.9 2.5 1.7 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat AAA PF00004.29 ETO09930.1 - 0.16 12.4 0.9 0.33 11.4 0.9 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PIN7 PF18475.1 ETO09930.1 - 0.19 12.4 0.1 0.19 12.4 0.1 3.6 3 1 1 4 4 4 0 PIN domain ANAPC3 PF12895.7 ETO09930.1 - 0.33 11.2 5.6 20 5.5 4.6 3.4 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 CDC27 PF09507.10 ETO09931.1 - 0.38 10.1 51.8 0.46 9.8 51.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SLC12 PF03522.15 ETO09931.1 - 1 8.3 30.6 1.4 7.9 30.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Lipase_3 PF01764.25 ETO09932.1 - 1e-30 106.4 0.3 1.8e-30 105.6 0.1 1.5 2 0 0 2 2 2 1 Lipase (class 3) Hydrolase_4 PF12146.8 ETO09932.1 - 0.00038 19.8 0.0 0.00058 19.2 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO09932.1 - 0.003 18.2 0.2 0.004 17.8 0.2 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family DUF2974 PF11187.8 ETO09932.1 - 0.034 13.7 0.0 0.33 10.5 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2974) PE-PPE PF08237.11 ETO09932.1 - 0.044 13.3 0.0 0.064 12.8 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain Cutinase PF01083.22 ETO09932.1 - 0.069 13.1 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Cutinase FKBP_C PF00254.28 ETO09933.1 - 2.3e-13 50.2 0.0 3.8e-13 49.6 0.0 1.4 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase Nop14 PF04147.12 ETO09933.1 - 6.5 4.8 12.9 8.9 4.4 12.9 1.1 1 0 0 1 1 1 0 Nop14-like family Pox_Ag35 PF03286.14 ETO09933.1 - 9.8 5.9 9.1 18 5.1 9.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RGS PF00615.19 ETO09934.1 - 0.00014 22.1 5.0 0.00027 21.2 3.2 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain ETRAMP PF09716.10 ETO09934.1 - 0.99 9.5 10.9 4.3 7.5 0.4 3.8 3 2 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) CENP-H PF05837.12 ETO09935.1 - 0.0018 18.6 14.1 0.0018 18.6 14.1 3.9 2 1 1 3 3 3 1 Centromere protein H (CENP-H) COG2 PF06148.11 ETO09935.1 - 0.0053 16.9 6.8 0.0053 16.9 6.8 3.9 3 1 1 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 Baculo_PEP_C PF04513.12 ETO09935.1 - 0.12 12.4 25.7 0.039 14.0 8.2 3.9 3 1 1 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Flt3_lig PF02947.14 ETO09935.1 - 0.43 10.8 4.6 0.45 10.7 0.1 2.8 2 2 1 3 3 3 0 flt3 ligand DUF948 PF06103.11 ETO09935.1 - 0.64 10.3 22.5 25 5.2 1.1 5.0 2 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) DUF2312 PF10073.9 ETO09935.1 - 0.86 9.3 9.5 5.8 6.6 2.7 3.5 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) Prefoldin PF02996.17 ETO09935.1 - 0.86 9.5 28.4 0.03 14.2 1.9 5.5 3 2 2 5 5 5 0 Prefoldin subunit JIP_LZII PF16471.5 ETO09935.1 - 1.6 9.0 24.7 0.057 13.6 16.3 3.0 3 1 0 3 3 3 0 JNK-interacting protein leucine zipper II FapA PF03961.13 ETO09935.1 - 2.4 6.7 27.1 0.29 9.7 4.9 2.5 2 1 0 2 2 2 0 Flagellar Assembly Protein A Jnk-SapK_ap_N PF09744.9 ETO09935.1 - 7.8 6.7 34.1 4 7.6 5.4 3.2 1 1 1 3 3 3 0 JNK_SAPK-associated protein-1 Cation_ATPase_C PF00689.21 ETO09937.1 - 0.0022 17.7 2.9 0.0034 17.1 2.9 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cyt_bd_oxida_II PF02322.15 ETO09937.1 - 0.0079 15.6 0.8 0.0091 15.4 0.8 1.1 1 0 0 1 1 1 1 Cytochrome bd terminal oxidase subunit II Colicin_V PF02674.16 ETO09937.1 - 0.016 15.2 1.3 0.024 14.6 1.3 1.2 1 0 0 1 1 1 0 Colicin V production protein LPG_synthase_TM PF03706.13 ETO09937.1 - 0.022 14.3 0.3 0.025 14.1 0.3 1.1 1 0 0 1 1 1 0 Lysylphosphatidylglycerol synthase TM region TMEM154 PF15102.6 ETO09937.1 - 0.071 13.0 0.1 0.071 13.0 0.1 2.3 2 2 0 2 2 2 0 TMEM154 protein family ABC2_membrane_4 PF12730.7 ETO09937.1 - 0.16 11.9 6.5 0.25 11.3 6.5 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein TMIE PF16038.5 ETO09937.1 - 0.28 11.1 0.2 0.28 11.1 0.2 2.4 3 0 0 3 3 2 0 TMIE protein Lectin_N PF03954.14 ETO09937.1 - 0.43 10.3 3.9 0.78 9.5 3.9 1.5 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain WBP-1 PF11669.8 ETO09937.1 - 2.4 8.8 4.6 0.67 10.6 0.3 2.2 1 1 2 3 3 3 0 WW domain-binding protein 1 SCIMP PF15050.6 ETO09937.1 - 2.7 8.5 5.1 6.2 7.3 0.4 2.3 1 1 1 2 2 2 0 SCIMP protein Vpu PF00558.19 ETO09937.1 - 2.7 7.8 6.6 6.1 6.7 1.1 2.3 2 0 0 2 2 2 0 Vpu protein Synaptobrevin PF00957.21 ETO09937.1 - 3 7.7 7.0 0.52 10.1 0.4 2.2 2 0 0 2 2 2 0 Synaptobrevin DUF4446 PF14584.6 ETO09937.1 - 7.9 6.4 7.3 1.1 9.2 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) IBV_3A PF03617.13 ETO09937.1 - 9.2 6.3 9.8 2.5 8.2 1.6 2.4 2 0 0 2 2 2 0 IBV 3A protein EF-hand_1 PF00036.32 ETO09938.1 - 4.2e-07 29.0 0.3 2.2e-06 26.8 0.3 2.3 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO09938.1 - 1.2e-06 28.0 1.3 3.7e-06 26.4 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ETO09938.1 - 4.3e-05 22.8 0.4 4.3e-05 22.8 0.4 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO09938.1 - 0.0005 20.5 0.8 0.0012 19.3 0.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair FPP PF05911.11 ETO09938.1 - 0.0069 14.6 14.9 0.06 11.5 2.9 2.1 1 1 1 2 2 2 2 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 ETO09938.1 - 0.11 11.4 19.1 1.6 7.5 20.2 2.1 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF3450 PF11932.8 ETO09938.1 - 0.53 9.5 20.1 0.28 10.5 2.2 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) SpecificRecomb PF10136.9 ETO09938.1 - 0.59 8.4 3.2 0.72 8.1 3.2 1.1 1 0 0 1 1 1 0 Site-specific recombinase TPR_MLP1_2 PF07926.12 ETO09938.1 - 1.2 9.2 20.7 0.32 11.1 7.0 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 ETO09938.1 - 6 6.9 12.0 4.2 7.4 5.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) bZIP_2 PF07716.15 ETO09938.1 - 9.1 6.5 13.9 6.3 7.0 2.0 3.5 3 1 0 3 3 3 0 Basic region leucine zipper Tyr-DNA_phospho PF06087.12 ETO09940.1 - 6.3e-78 262.6 4.3 4.3e-77 259.8 1.7 2.2 1 1 1 2 2 2 2 Tyrosyl-DNA phosphodiesterase OB_Dis3 PF17849.1 ETO09941.1 - 2.6e-08 33.8 0.0 2.2e-05 24.4 0.0 2.6 2 0 0 2 2 2 2 Dis3-like cold-shock domain 2 (CSD2) Rrp44_CSD1 PF17216.3 ETO09941.1 - 5.3e-06 26.2 0.2 5.3e-06 26.2 0.2 2.3 1 1 1 2 2 2 1 Rrp44-like cold shock domain TMEM214 PF10151.9 ETO09941.1 - 2.2 6.7 8.8 3.8 5.9 8.8 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator PPL5 PF18168.1 ETO09941.1 - 8.3 5.6 10.5 19 4.4 10.5 1.6 1 0 0 1 1 1 0 Prim-pol family 5 EPL1 PF10513.9 ETO09944.1 - 0.21 12.0 7.8 0.43 11.0 7.8 1.8 1 1 0 1 1 1 0 Enhancer of polycomb-like Apis_Csd PF11671.8 ETO09944.1 - 0.56 10.2 8.8 1.1 9.2 8.8 1.6 1 0 0 1 1 1 0 Complementary sex determiner protein Exo_endo_phos_2 PF14529.6 ETO09945.1 - 1.6e-17 63.4 2.1 1.6e-17 63.4 2.1 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO09945.1 - 0.0013 18.4 1.1 0.0013 18.4 1.1 1.8 2 1 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family RabGAP-TBC PF00566.18 ETO09946.1 - 3e-24 85.9 0.4 3.5e-24 85.7 0.4 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain 2Fe-2S_thioredx PF01257.19 ETO09946.1 - 0.025 14.5 0.0 0.041 13.7 0.0 1.3 1 0 0 1 1 1 0 Thioredoxin-like [2Fe-2S] ferredoxin GCIP PF13324.6 ETO09947.1 - 2.7 7.5 14.1 0.1 12.2 3.6 2.4 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting MAP17 PF15807.5 ETO09948.1 - 0.0008 19.6 0.1 0.0019 18.4 0.1 1.6 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 HemY_N PF07219.13 ETO09948.1 - 0.19 11.9 0.4 0.32 11.2 0.4 1.3 1 0 0 1 1 1 0 HemY protein N-terminus TarH PF02203.15 ETO09948.1 - 0.25 11.3 0.7 0.38 10.6 0.7 1.2 1 0 0 1 1 1 0 Tar ligand binding domain homologue Syndecan PF01034.20 ETO09948.1 - 0.31 11.0 1.3 0.67 9.9 0.6 1.9 2 0 0 2 2 2 0 Syndecan domain EamA PF00892.20 ETO09949.1 - 0.031 14.5 3.7 0.052 13.7 3.7 1.3 1 0 0 1 1 1 0 EamA-like transporter family ODV-E18 PF10717.9 ETO09949.1 - 2.1 8.3 3.7 1.4 8.9 0.8 2.0 1 1 1 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 WD40 PF00400.32 ETO09950.1 - 3e-29 100.6 8.0 2.3e-10 40.9 0.1 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09950.1 - 4.1e-08 33.4 0.2 0.0024 18.1 0.0 2.4 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09950.1 - 0.0026 16.8 0.1 0.81 8.6 0.0 2.6 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO09950.1 - 0.014 14.1 0.9 5.4 5.5 0.1 2.9 1 1 1 3 3 3 0 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO09950.1 - 0.14 12.2 0.1 8.8 6.4 0.1 2.6 1 1 0 2 2 2 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO09951.1 - 1.4e-14 54.2 0.2 3.8e-07 30.7 0.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO09951.1 - 2.1e-07 30.3 0.0 0.0019 17.3 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO09951.1 - 4e-07 30.2 0.1 0.0012 19.1 0.1 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09951.1 - 0.0025 16.6 0.2 1.2 7.7 0.2 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Utp8 PF10395.9 ETO09951.1 - 0.029 12.9 0.2 0.069 11.6 0.2 1.6 1 1 0 1 1 1 0 Utp8 family Cytochrom_D1 PF02239.16 ETO09951.1 - 0.041 12.4 0.0 0.063 11.8 0.0 1.4 1 0 0 1 1 1 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO09951.1 - 0.067 13.2 0.3 6.1 6.9 0.0 2.9 2 1 0 2 2 2 0 WD40-like Beta Propeller Repeat OTCace_N PF02729.21 ETO09954.1 - 3.5e-46 156.9 0.0 5.3e-46 156.3 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain OTCace PF00185.24 ETO09954.1 - 7.7e-41 139.8 0.0 1.3e-40 139.1 0.0 1.3 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain Toxin_6 PF05453.12 ETO09954.1 - 1.1 9.8 3.9 7.2 7.2 0.3 2.6 2 0 0 2 2 2 0 BmTXKS1/BmP02 toxin family Sec16_C PF12931.7 ETO09956.1 - 7.7e-08 32.3 0.4 9e-08 32.1 0.4 1.0 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 Pkinase PF00069.25 ETO09958.1 - 3.7e-13 49.5 0.3 9.7e-13 48.1 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain SlpA PF03217.14 ETO09958.1 - 3.9 8.2 9.5 0.46 11.1 4.7 2.0 2 0 0 2 2 2 0 Surface later protein A domain Pkinase PF00069.25 ETO09959.1 - 9.7e-09 35.0 4.4 0.00022 20.7 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO09959.1 - 5.6e-05 22.6 4.9 0.029 13.7 0.1 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase BK_channel_a PF03493.18 ETO09959.1 - 0.0043 17.2 0.3 0.0094 16.1 0.3 1.5 1 0 0 1 1 1 1 Calcium-activated BK potassium channel alpha subunit DAP_epimerase PF01678.19 ETO09960.1 - 2.7e-27 95.3 0.0 1e-12 48.3 0.0 3.1 3 0 0 3 3 3 3 Diaminopimelate epimerase WD40 PF00400.32 ETO09961.1 - 1e-27 95.8 25.3 1.1e-06 29.2 0.5 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09961.1 - 3.5e-06 27.2 0.5 0.44 10.9 0.0 3.5 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09961.1 - 6.4e-06 25.1 0.2 1.1 7.8 0.0 3.1 3 0 0 3 3 3 3 Nucleoporin Nup120/160 FBPase PF00316.20 ETO09961.1 - 0.073 12.5 0.0 0.61 9.5 0.0 2.1 2 0 0 2 2 2 0 Fructose-1-6-bisphosphatase, N-terminal domain WD40 PF00400.32 ETO09962.1 - 2.5e-30 104.0 25.0 8.5e-06 26.4 0.2 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO09962.1 - 1.9e-06 26.8 8.2 0.018 13.7 0.4 4.3 2 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09962.1 - 2.8e-06 27.5 0.6 0.13 12.5 0.0 3.7 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09962.1 - 0.0015 17.9 6.1 0.12 11.7 0.7 3.1 2 1 1 3 3 3 2 WD40-like domain PQQ_3 PF13570.6 ETO09962.1 - 0.033 14.7 0.1 80 3.9 0.0 3.7 4 0 0 4 4 4 0 PQQ-like domain DUF4221 PF13970.6 ETO09962.1 - 0.37 10.3 5.0 0.31 10.6 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) REPA_OB_2 PF16900.5 ETO09963.1 - 0.014 15.3 0.9 0.014 15.3 0.9 1.7 1 1 1 2 2 2 0 Replication protein A OB domain PINIT PF14324.6 ETO09963.1 - 0.056 13.8 4.3 0.2 12.0 1.2 2.1 1 1 1 2 2 2 0 PINIT domain GDC-P PF02347.16 ETO09963.1 - 0.075 11.8 1.5 0.085 11.7 1.5 1.1 1 0 0 1 1 1 0 Glycine cleavage system P-protein PRD PF00874.20 ETO09963.1 - 2.7 8.4 11.2 2 8.8 6.1 2.2 1 1 1 2 2 2 0 PRD domain U-box PF04564.15 ETO09964.1 - 8e-13 48.4 0.0 2.8e-12 46.6 0.0 2.0 1 0 0 1 1 1 1 U-box domain HEPN_Toprim_N PF18871.1 ETO09964.1 - 0.027 14.4 4.9 0.17 11.8 0.1 2.1 1 1 1 2 2 2 0 HEPN/Toprim N-terminal domain 1 TraN PF06986.11 ETO09964.1 - 0.039 13.7 2.2 0.043 13.5 1.5 1.3 1 1 0 1 1 1 0 Type-1V conjugative transfer system mating pair stabilisation FliJ PF02050.16 ETO09964.1 - 0.63 10.3 7.9 9 6.5 0.9 2.8 2 1 1 3 3 3 0 Flagellar FliJ protein WD40 PF00400.32 ETO09965.1 - 7.7e-23 80.4 1.4 8.1e-05 23.3 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09965.1 - 9.4e-05 22.6 0.2 0.022 15.1 0.0 3.2 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO09965.1 - 0.00032 19.8 0.1 0.0051 15.8 0.0 2.1 1 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein dsRBD2 PF17842.1 ETO09965.1 - 0.12 12.5 1.8 0.21 11.8 1.8 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 SRA PF18491.1 ETO09965.1 - 1.7 8.8 8.2 0.17 12.0 2.2 2.2 3 0 0 3 3 3 0 SET and RING associated domain WD40 PF00400.32 ETO09966.1 - 1.6e-21 76.2 6.7 1.6e-05 25.6 0.1 5.0 4 3 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO09966.1 - 4.5e-05 22.3 0.1 1.4 7.5 0.0 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO09966.1 - 0.00092 19.5 0.1 3.6 8.0 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain IRF PF00605.17 ETO09967.1 - 0.52 10.6 8.5 1.1 9.6 6.4 2.1 2 0 0 2 2 2 0 Interferon regulatory factor transcription factor DUF2513 PF10711.9 ETO09968.1 - 0.043 14.1 0.2 0.056 13.7 0.2 1.2 1 0 0 1 1 1 0 Hypothetical protein (DUF2513) CFIA_Pcf11 PF11526.8 ETO09970.1 - 0.012 16.1 1.1 1.7 9.2 0.0 2.5 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 zf-TRAF PF02176.18 ETO09971.1 - 3.3e-06 27.7 6.9 3.3e-06 27.7 6.9 2.6 2 1 1 3 3 3 1 TRAF-type zinc finger WD40 PF00400.32 ETO09972.1 - 1.4e-20 73.2 13.9 5.1e-06 27.1 0.5 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09972.1 - 8.5e-10 38.8 0.1 0.0054 17.0 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO09972.1 - 1.4e-06 27.9 2.5 0.00088 18.7 0.7 2.6 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO09972.1 - 1.2e-05 24.2 0.5 0.057 12.1 0.1 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 C2 PF00168.30 ETO09973.1 - 4.7e-10 39.7 0.1 8.6e-10 38.8 0.1 1.4 1 0 0 1 1 1 1 C2 domain WD40 PF00400.32 ETO09974.1 - 2.3e-27 94.7 13.1 2.7e-09 37.5 0.1 6.1 6 1 0 6 6 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO09974.1 - 5.4e-15 55.5 2.0 0.0054 17.0 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO09974.1 - 6.6e-07 28.3 3.2 0.099 11.3 1.0 3.8 2 2 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO09974.1 - 2.1e-05 24.0 3.6 0.00038 19.9 0.2 2.5 1 1 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 ETO09974.1 - 6e-05 22.2 2.9 0.067 12.1 0.1 4.2 1 1 4 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ETO09974.1 - 0.00085 19.1 0.1 6.7 6.8 0.0 4.1 5 0 0 5 5 4 1 PQQ enzyme repeat P34-Arc PF04045.14 ETO09974.1 - 0.0095 15.7 0.7 0.032 13.9 0.1 2.1 3 0 0 3 3 3 1 Arp2/3 complex, 34 kD subunit p34-Arc PQQ_2 PF13360.6 ETO09974.1 - 0.017 14.7 0.1 4.4 6.8 0.0 2.2 1 1 0 2 2 2 0 PQQ-like domain Cytochrom_D1 PF02239.16 ETO09974.1 - 0.02 13.4 0.2 0.38 9.2 0.1 2.1 1 1 2 3 3 3 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO09974.1 - 0.061 12.2 0.1 1.9 7.3 0.0 2.7 1 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) GTP_EFTU_D4 PF14578.6 ETO09974.1 - 0.17 11.8 0.2 0.32 10.9 0.2 1.4 1 0 0 1 1 1 0 Elongation factor Tu domain 4 ECH_1 PF00378.20 ETO09976.1 - 1e-09 38.1 0.0 1.2e-09 37.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO09976.1 - 1.2e-06 28.3 0.0 1.4e-06 28.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase WD40 PF00400.32 ETO09977.1 - 2.4e-09 37.7 1.9 4e-05 24.3 0.2 3.0 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO09977.1 - 0.053 12.2 0.1 0.41 9.2 0.0 1.8 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Myb_DNA-bind_7 PF15963.5 ETO09978.1 - 0.026 14.4 0.1 0.065 13.1 0.0 1.6 1 1 0 1 1 1 0 Myb DNA-binding like Myb_DNA-binding PF00249.31 ETO09978.1 - 0.045 14.0 0.8 0.076 13.2 0.1 1.7 2 0 0 2 2 2 0 Myb-like DNA-binding domain SDA1 PF05285.12 ETO09979.1 - 0.011 15.2 1.2 0.011 15.2 1.2 1.0 1 0 0 1 1 1 0 SDA1 Phage_holin_3_6 PF07332.11 ETO09979.1 - 0.033 14.2 7.0 0.066 13.2 6.9 1.5 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Claudin_2 PF13903.6 ETO09979.1 - 0.092 12.5 0.0 0.092 12.5 0.0 1.8 2 0 0 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction RSN1_TM PF13967.6 ETO09979.1 - 0.13 12.0 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport DNA_pol_phi PF04931.13 ETO09979.1 - 2.2 6.3 11.6 2.6 6.0 11.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETO09979.1 - 7.8 4.9 5.0 8.7 4.7 5.0 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Synapsin_C PF02750.14 ETO09980.1 - 6.2e-20 71.6 1.0 2.8e-14 53.1 0.0 2.6 2 1 0 2 2 2 2 Synapsin, ATP binding domain Allexi_40kDa PF05549.11 ETO09981.1 - 0.017 14.6 0.1 0.02 14.4 0.1 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF4635 PF15466.6 ETO09981.1 - 0.078 12.5 0.3 0.12 11.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4635) Acetyltransf_9 PF13527.7 ETO09981.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain DASH_Dad3 PF08656.10 ETO09981.1 - 0.13 12.4 0.6 0.24 11.5 0.6 1.4 1 0 0 1 1 1 0 DASH complex subunit Dad3 RT_RNaseH_2 PF17919.1 ETO09982.1 - 1.2e-18 66.9 0.0 2.4e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ETO09982.1 - 2.1e-08 33.9 0.1 4e-08 33.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 ETO09982.1 - 5.7e-08 33.0 0.2 1.1e-06 28.8 0.0 2.4 1 1 1 2 2 2 1 RNase H-like domain found in reverse transcriptase Glyco_hydro_114 PF03537.13 ETO09982.1 - 0.0025 17.1 0.1 0.0032 16.8 0.1 1.2 1 0 0 1 1 1 1 Glycoside-hydrolase family GH114 UPF0225 PF17775.1 ETO09982.1 - 0.061 14.1 0.1 0.092 13.6 0.1 1.3 1 0 0 1 1 1 0 UPF0225 domain Mrpl_C PF18502.1 ETO09982.1 - 0.065 13.5 0.9 0.18 12.1 0.9 1.8 1 1 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain Baculo_PEP_C PF04513.12 ETO09982.1 - 0.094 12.8 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus GRP PF07172.11 ETO09985.1 - 0.01 16.5 13.4 0.01 16.5 13.4 2.4 2 1 0 2 2 2 0 Glycine rich protein family HMD PF03201.16 ETO09985.1 - 1.8 8.8 9.9 2 8.7 2.7 2.8 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase FYDLN_acid PF09538.10 ETO09985.1 - 5.7 7.7 18.7 0.8 10.4 8.7 2.8 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Tub_N PF16322.5 ETO09985.1 - 8.3 6.8 27.3 4.6 7.6 11.8 2.7 2 0 0 2 2 2 0 Tubby N-terminal RRM_1 PF00076.22 ETO09986.1 - 1.4e-17 63.2 0.1 2.3e-17 62.6 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO09986.1 - 0.00017 21.4 0.0 0.00041 20.1 0.0 1.7 1 0 0 1 1 1 1 Occluded RNA-recognition motif Nab6_mRNP_bdg PF10567.9 ETO09986.1 - 0.019 14.4 0.2 0.68 9.4 0.0 2.1 2 0 0 2 2 2 0 RNA-recognition motif RRM_5 PF13893.6 ETO09986.1 - 0.048 13.2 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PIH1_CS PF18201.1 ETO09987.1 - 6.1e-07 29.8 0.6 1e-06 29.0 0.6 1.3 1 0 0 1 1 1 1 PIH1 CS-like domain PEPCK_N PF17297.2 ETO09988.1 - 2.3e-38 132.0 0.0 3.3e-38 131.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain DUF2357 PF09823.9 ETO09988.1 - 0.018 14.3 0.4 0.03 13.6 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2357) Ndr PF03096.14 ETO09988.1 - 0.19 10.4 2.6 0.29 9.8 2.6 1.3 1 0 0 1 1 1 0 Ndr family PEPCK_GTP PF00821.18 ETO09989.1 - 9.9e-163 541.1 0.6 1.2e-162 540.9 0.6 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 ETO09989.1 - 6.1e-31 107.7 0.0 9.3e-31 107.1 0.0 1.3 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase N-terminal domain Kelch_1 PF01344.25 ETO09990.1 - 0.0067 16.0 0.1 0.37 10.4 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO09990.1 - 0.0089 16.3 0.1 0.31 11.4 0.0 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO09990.1 - 0.019 14.9 1.3 4.8 7.3 0.0 3.2 3 1 0 3 3 3 0 Kelch motif Cullin_binding PF03556.15 ETO09990.1 - 0.028 14.9 0.0 0.04 14.3 0.0 1.3 1 0 0 1 1 1 0 Cullin binding Kelch_5 PF13854.6 ETO09990.1 - 0.06 13.3 0.6 1.5 8.9 0.0 2.7 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO09990.1 - 0.084 13.2 0.0 31 5.0 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain GPS PF01825.21 ETO09990.1 - 0.21 12.1 0.6 0.21 12.1 0.6 1.8 2 0 0 2 2 2 0 GPCR proteolysis site, GPS, motif LIM PF00412.22 ETO09991.1 - 6.5e-14 51.9 25.1 1.4e-08 34.8 6.7 3.1 3 1 0 3 3 3 2 LIM domain zf-C2H2_7 PF15269.6 ETO09991.1 - 0.91 9.7 6.3 5.8 7.1 0.7 2.7 2 0 0 2 2 2 0 Zinc-finger Vps39_2 PF10367.9 ETO09991.1 - 1.3 9.5 13.9 0.58 10.6 1.8 3.6 2 1 2 4 4 4 0 Vacuolar sorting protein 39 domain 2 DUF2175 PF09943.9 ETO09991.1 - 2.3 8.6 13.5 0.031 14.5 4.2 2.4 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) Aldo_ket_red PF00248.21 ETO09993.1 - 2e-11 43.7 0.1 3.9e-09 36.1 0.1 2.1 1 1 0 1 1 1 1 Aldo/keto reductase family FMO-like PF00743.19 ETO09994.1 - 4e-07 28.8 0.0 5e-07 28.5 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Collagen_bind_2 PF12904.7 ETO09995.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative collagen-binding domain of a collagenase DivIC PF04977.15 ETO09995.1 - 0.15 11.9 3.3 0.42 10.4 3.3 1.9 1 1 0 1 1 1 0 Septum formation initiator MIT PF04212.18 ETO09997.1 - 0.0026 17.8 3.2 0.0026 17.8 3.2 2.4 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain DUF2877 PF11392.8 ETO09997.1 - 0.022 15.5 1.4 0.022 15.5 1.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) Plk4_PB2 PF18409.1 ETO09997.1 - 0.044 14.5 1.1 0.044 14.5 1.1 3.8 4 0 0 4 4 4 0 Polo-like Kinase 4 Polo Box 2 ZIP4_domain PF18292.1 ETO09997.1 - 5.4 6.9 10.7 1.9 8.4 4.3 2.5 2 0 0 2 2 2 0 Zinc transporter ZIP4 domain Chlamy_scaf PF09675.10 ETO09998.1 - 0.042 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Chlamydia-phage Chp2 scaffold (Chlamy_scaf) EF-hand_6 PF13405.6 ETO09998.1 - 0.054 13.4 2.2 10 6.3 0.0 3.8 3 1 1 4 4 4 0 EF-hand domain DUF3915 PF13054.6 ETO09999.1 - 0.084 12.9 0.2 0.11 12.5 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Mucin PF01456.17 ETO09999.1 - 0.11 12.4 18.6 0.15 12.1 18.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Smg8_Smg9 PF10220.9 ETO09999.1 - 0.19 10.0 5.2 0.2 9.9 5.2 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Dicty_REP PF05086.12 ETO09999.1 - 0.28 9.1 9.6 0.34 8.9 9.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PAP1 PF08601.10 ETO09999.1 - 1.4 8.5 11.9 1.6 8.4 11.9 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 Menin PF05053.13 ETO09999.1 - 2 6.7 7.4 2.2 6.5 7.4 1.1 1 0 0 1 1 1 0 Menin WD40 PF00400.32 ETO10000.1 - 6.4e-07 30.0 11.0 0.00011 22.9 0.3 5.2 5 0 0 5 5 5 1 WD domain, G-beta repeat NAM-associated PF14303.6 ETO10000.1 - 1 10.1 52.5 0.036 14.8 23.4 3.5 4 0 0 4 4 4 0 No apical meristem-associated C-terminal domain SR-25 PF10500.9 ETO10000.1 - 9.3 5.8 34.6 0.64 9.6 5.7 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein Utp14 PF04615.13 ETO10000.1 - 9.6 4.6 50.9 3.7 6.0 41.7 2.4 2 0 0 2 2 2 0 Utp14 protein DUF1773 PF08593.10 ETO10001.1 - 2.4 9.2 11.4 0.44 11.6 2.3 3.2 3 0 0 3 3 3 0 Domain of unknown function SNF2_N PF00176.23 ETO10002.1 - 1.5e-14 53.5 0.0 2.7e-14 52.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Chromo PF00385.24 ETO10002.1 - 1.1e-09 38.1 0.0 2e-06 27.6 0.0 2.4 2 0 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain SNF2_N PF00176.23 ETO10003.1 - 1.9e-40 138.7 3.3 3.1e-40 138.0 3.3 1.4 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO10003.1 - 3.2e-19 69.3 0.0 1e-18 67.7 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ETO10003.1 - 1.3e-12 47.6 0.1 3.8e-12 46.0 0.0 1.8 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ETO10003.1 - 0.019 15.0 0.7 0.48 10.4 0.0 3.0 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ETO10003.1 - 0.042 13.5 0.0 0.1 12.2 0.0 1.6 1 0 0 1 1 1 0 SWI2/SNF2 ATPase ANAPC4 PF12896.7 ETO10003.1 - 0.043 13.3 0.0 0.19 11.2 0.0 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 4 NACHT PF05729.12 ETO10005.1 - 1e-11 45.0 0.0 1.8e-11 44.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO10005.1 - 0.00012 22.4 1.5 0.00048 20.4 0.8 2.2 1 1 1 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO10005.1 - 0.0015 19.0 2.8 0.0018 18.9 0.2 2.2 1 1 1 2 2 2 1 AAA domain AAA_17 PF13207.6 ETO10005.1 - 0.0064 16.9 0.0 0.02 15.3 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO10005.1 - 0.009 16.4 0.2 0.056 13.8 0.2 2.1 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO10005.1 - 0.021 14.7 2.0 0.049 13.5 0.1 2.3 1 1 2 3 3 3 0 RsgA GTPase NGF PF00243.18 ETO10005.1 - 0.023 14.9 0.5 0.05 13.9 0.2 1.7 1 1 1 2 2 2 0 Nerve growth factor family TsaE PF02367.17 ETO10005.1 - 0.037 14.0 0.0 0.1 12.6 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETO10005.1 - 0.057 13.9 2.2 0.062 13.8 1.2 1.7 1 1 0 1 1 1 0 ABC transporter AAA_30 PF13604.6 ETO10005.1 - 0.081 12.6 0.0 0.13 11.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO10005.1 - 0.13 12.0 0.0 0.28 11.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ETO10005.1 - 0.13 12.6 0.2 0.13 12.6 0.2 2.9 3 1 0 3 3 3 0 RNA helicase EF-hand_1 PF00036.32 ETO10005.1 - 0.61 9.8 4.5 0.58 9.8 2.2 2.3 2 0 0 2 2 2 0 EF hand TetR_C_26 PF17934.1 ETO10005.1 - 1.2 9.5 6.2 0.39 11.1 0.2 2.9 2 2 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain AAA_21 PF13304.6 ETO10005.1 - 1.8 8.3 7.0 0.64 9.8 3.0 2.1 2 1 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system RNase_H PF00075.24 ETO10006.1 - 1e-18 67.9 0.1 1e-18 67.9 0.1 1.7 2 0 0 2 2 2 1 RNase H RVT_3 PF13456.6 ETO10006.1 - 0.03 14.2 0.3 0.83 9.5 0.3 3.2 1 1 0 1 1 1 0 Reverse transcriptase-like KH_6 PF15985.5 ETO10007.1 - 1.8e-07 31.4 0.0 4.1e-07 30.2 0.0 1.7 1 0 0 1 1 1 1 KH domain EpsG PF14897.6 ETO10008.1 - 0.0027 17.1 14.5 0.0039 16.5 14.5 1.2 1 0 0 1 1 1 1 EpsG family Nro1 PF12753.7 ETO10008.1 - 0.088 11.8 0.0 0.12 11.3 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Ctr PF04145.15 ETO10008.1 - 6.1 7.5 9.9 3.1 8.4 0.5 3.1 2 1 0 3 3 3 0 Ctr copper transporter family DUF3552 PF12072.8 ETO10010.1 - 0.81 9.1 49.1 0.018 14.4 11.1 4.4 4 1 0 4 4 4 0 Domain of unknown function (DUF3552) PRK PF00485.18 ETO10011.1 - 1.1e-07 31.8 0.4 2e-06 27.7 0.4 2.2 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ETO10011.1 - 0.001 19.6 0.5 0.0027 18.2 0.5 1.8 1 1 0 1 1 1 1 AAA domain ELP6 PF09807.9 ETO10011.1 - 0.0015 18.0 0.8 0.0048 16.4 0.7 1.7 1 1 0 1 1 1 1 Elongation complex protein 6 AAA_33 PF13671.6 ETO10011.1 - 0.0043 17.2 0.0 0.027 14.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 ETO10011.1 - 0.0076 16.2 0.1 0.025 14.6 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE KAP_NTPase PF07693.14 ETO10011.1 - 0.017 14.4 0.0 0.024 13.9 0.0 1.4 1 1 0 1 1 1 0 KAP family P-loop domain MobB PF03205.14 ETO10011.1 - 0.022 14.7 0.0 0.1 12.5 0.0 2.0 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 ETO10011.1 - 0.029 14.9 0.6 0.063 13.8 0.1 1.8 2 0 0 2 2 2 0 ABC transporter AAA_22 PF13401.6 ETO10011.1 - 0.035 14.4 0.0 0.075 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO10011.1 - 0.039 13.4 0.0 0.075 12.5 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein Rad17 PF03215.15 ETO10011.1 - 0.045 13.7 0.2 0.5 10.3 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain AAA_5 PF07728.14 ETO10011.1 - 0.14 12.1 0.3 0.41 10.6 0.0 1.9 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO10011.1 - 0.14 12.6 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) GST_C_6 PF17171.4 ETO10012.1 - 3.5e-06 26.7 0.2 1.2e-05 24.9 0.0 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain Tom37 PF10568.9 ETO10012.1 - 0.0074 16.6 0.9 0.019 15.3 0.3 2.0 2 1 0 2 2 2 1 Outer mitochondrial membrane transport complex protein DUF5056 PF16479.5 ETO10013.1 - 0.1 12.8 0.8 1 9.6 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF5056) DUF2969 PF11184.8 ETO10013.1 - 0.69 10.4 12.5 1.3 9.4 10.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2969) LRRC37AB_C PF14914.6 ETO10014.1 - 0.061 13.2 13.6 0.079 12.9 13.6 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain FAM176 PF14851.6 ETO10014.1 - 0.78 9.4 7.7 1.2 8.7 7.7 1.3 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 ETO10014.1 - 1.2 8.9 9.2 1.4 8.6 9.2 1.3 1 0 0 1 1 1 0 Connexin Folate_carrier PF01770.18 ETO10014.1 - 1.7 7.3 3.8 1.7 7.3 3.8 1.1 1 0 0 1 1 1 0 Reduced folate carrier SID-1_RNA_chan PF13965.6 ETO10014.1 - 3.6 5.9 11.5 3.7 5.8 11.5 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 ETO10014.1 - 4.8 6.0 6.5 5.2 5.9 6.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 ETO10014.1 - 5 5.8 11.4 5.5 5.6 11.4 1.2 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 ETO10014.1 - 5.1 6.0 6.7 5.6 5.9 6.7 1.1 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 ETO10014.1 - 9 5.4 9.5 8.9 5.4 9.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_S10 PF00450.22 ETO10015.1 - 4.4e-16 59.3 1.0 3e-08 33.5 0.1 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase WD40 PF00400.32 ETO10016.1 - 3.5e-25 87.8 17.5 4.3e-07 30.5 0.9 5.4 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10016.1 - 7.7e-10 38.9 1.9 0.0029 17.9 0.0 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10016.1 - 0.00028 19.7 4.5 0.31 9.6 0.2 3.3 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO10016.1 - 0.00043 19.7 1.1 0.00043 19.7 1.1 2.1 2 1 0 2 2 2 1 WD40-like domain DUF4221 PF13970.6 ETO10016.1 - 0.12 11.9 2.8 1.1 8.7 2.8 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4221) Laminin_G_3 PF13385.6 ETO10017.1 - 4.2e-13 49.7 16.1 2.7e-11 43.8 4.0 3.7 3 1 0 3 3 3 2 Concanavalin A-like lectin/glucanases superfamily WSC PF01822.19 ETO10017.1 - 3.9e-11 43.0 11.0 3.9e-11 43.0 11.0 2.4 3 0 0 3 3 3 1 WSC domain Laminin_G_2 PF02210.24 ETO10017.1 - 0.0043 17.6 0.4 0.039 14.5 0.1 2.6 2 0 0 2 2 2 1 Laminin G domain Pentaxin PF00354.17 ETO10017.1 - 0.0054 16.5 1.9 0.011 15.5 0.1 2.4 3 0 0 3 3 3 1 Pentaxin family Lectin_C PF00059.21 ETO10017.1 - 0.025 15.3 2.5 0.025 15.3 2.5 3.2 4 0 0 4 4 4 0 Lectin C-type domain Aminotran_1_2 PF00155.21 ETO10017.1 - 0.034 13.3 0.0 0.061 12.5 0.0 1.3 1 0 0 1 1 1 0 Aminotransferase class I and II Pkinase PF00069.25 ETO10018.1 - 0.0065 15.9 0.1 0.012 14.9 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain UBA_2 PF08587.11 ETO10018.1 - 0.032 14.3 0.0 0.073 13.2 0.0 1.6 1 0 0 1 1 1 0 Ubiquitin associated domain (UBA) SH3BGR PF04908.15 ETO10018.1 - 0.04 14.1 4.3 3.9 7.7 0.3 2.5 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein XK-related PF09815.9 ETO10019.1 - 1.5e-12 47.3 25.8 1.5e-12 47.3 25.8 2.5 2 1 1 3 3 3 1 XK-related protein DUF4452 PF14618.6 ETO10019.1 - 0.37 10.6 2.3 0.46 10.3 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4452) SRP9-21 PF05486.12 ETO10019.1 - 1.5 9.3 6.8 4.2 7.8 0.4 2.9 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) adh_short_C2 PF13561.6 ETO10020.1 - 3.1e-49 167.6 0.4 3e-48 164.4 0.1 2.1 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO10020.1 - 3.1e-43 147.5 2.2 1.7e-35 122.2 0.2 2.3 2 0 0 2 2 2 2 short chain dehydrogenase Spt20 PF12090.8 ETO10020.1 - 4.4e-05 23.2 14.1 0.0069 16.0 2.9 2.2 2 0 0 2 2 2 2 Spt20 family Sporozoite_P67 PF05642.11 ETO10020.1 - 0.00028 19.2 2.1 0.00028 19.2 2.1 1.6 2 0 0 2 2 2 1 Sporozoite P67 surface antigen RNA_pol_Rpc4 PF05132.14 ETO10020.1 - 0.0068 16.9 10.2 0.11 12.9 0.5 2.4 2 0 0 2 2 2 2 RNA polymerase III RPC4 TERB2 PF15101.6 ETO10020.1 - 0.43 10.6 13.0 0.11 12.5 1.6 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF2828 PF11443.8 ETO10020.1 - 0.8 7.7 18.7 0.14 10.2 1.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) Zip PF02535.22 ETO10020.1 - 2.3 7.4 13.0 5.2 6.2 6.3 2.4 2 1 0 2 2 2 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO10020.1 - 2.4 9.1 22.0 0.14 13.1 1.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SLC12 PF03522.15 ETO10020.1 - 2.9 6.8 19.5 1.4 7.9 2.9 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Hid1 PF12722.7 ETO10020.1 - 5.4 5.0 12.4 1.2 7.2 2.3 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein DUF913 PF06025.12 ETO10020.1 - 7 5.5 11.4 1.2 8.0 0.6 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF3391 PF11871.8 ETO10020.1 - 8.5 6.9 13.2 3.5 8.2 2.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) ASH PF15780.5 ETO10021.1 - 2.4e-06 27.6 0.1 1.7 8.9 0.0 4.0 3 1 1 4 4 4 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Baculo_11_kDa PF06143.11 ETO10022.1 - 0.74 9.4 5.3 0.94 9.1 4.1 1.9 1 1 0 1 1 1 0 Baculovirus 11 kDa family SAM35 PF10806.8 ETO10022.1 - 1.6 9.0 6.8 15 5.9 3.1 2.5 2 0 0 2 2 2 0 SAM35, subunit of SAM coomplex AIF-MLS PF14962.6 ETO10022.1 - 1.9 8.4 6.6 1.1 9.2 4.1 1.8 1 1 0 1 1 1 0 Mitochondria Localisation Sequence DUF3446 PF11928.8 ETO10023.1 - 0.22 11.9 14.5 0.26 11.6 13.5 1.6 2 0 0 2 2 2 0 Early growth response N-terminal domain G-alpha PF00503.20 ETO10024.1 - 2.7e-48 164.9 4.8 4e-26 92.0 0.3 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO10024.1 - 4.6e-07 29.4 0.1 7.8e-06 25.5 0.0 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF3048 PF11258.8 ETO10024.1 - 0.00046 20.3 0.1 0.0012 19.0 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF3048) N-terminal domain VasI PF11319.8 ETO10024.1 - 0.12 12.0 0.6 0.22 11.1 0.1 1.7 2 1 0 2 2 2 0 Type VI secretion system VasI, EvfG, VC_A0118 WD40 PF00400.32 ETO10025.1 - 8.6e-07 29.6 0.0 6.2e-06 26.8 0.1 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10025.1 - 0.0028 17.9 0.0 0.24 11.7 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain EF-hand_7 PF13499.6 ETO10026.1 - 5.4e-11 42.8 6.5 3e-09 37.2 0.7 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO10026.1 - 5.9e-08 31.7 4.2 4.4e-05 22.7 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO10026.1 - 2.4e-07 30.1 4.3 0.0091 15.9 0.6 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO10026.1 - 3e-07 29.6 0.8 1.8e-06 27.2 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO10026.1 - 1.6e-05 24.6 1.9 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair Med2 PF11214.8 ETO10029.1 - 0.05 13.8 1.3 0.21 11.8 0.4 2.2 2 0 0 2 2 2 0 Mediator complex subunit 2 CAF1 PF04857.20 ETO10030.1 - 1e-30 107.0 1.9 1.3e-19 70.6 0.8 2.2 2 0 0 2 2 2 2 CAF1 family ribonuclease Prefoldin_2 PF01920.20 ETO10031.1 - 0.00086 19.2 0.2 0.0012 18.7 0.2 1.2 1 0 0 1 1 1 1 Prefoldin subunit Rsc14 PF08586.10 ETO10033.1 - 0.088 13.6 0.8 0.17 12.7 0.3 1.7 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit PIRT PF15099.6 ETO10033.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family FSA_C PF10479.9 ETO10034.1 - 0.0007 17.9 9.2 0.00092 17.5 9.2 1.1 1 0 0 1 1 1 1 Fragile site-associated protein C-terminus DUF1772 PF08592.11 ETO10034.1 - 0.0038 17.5 1.0 0.0092 16.3 1.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF1772) Dicty_REP PF05086.12 ETO10034.1 - 0.017 13.2 7.0 0.029 12.4 7.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Serinc PF03348.15 ETO10034.1 - 0.071 12.0 8.9 2.6 6.9 0.1 2.3 2 0 0 2 2 2 0 Serine incorporator (Serinc) DUF3439 PF11921.8 ETO10034.1 - 0.28 11.1 18.9 0.89 9.5 18.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SelP_N PF04592.14 ETO10034.1 - 0.36 10.2 24.8 0.025 14.0 14.4 2.2 2 0 0 2 2 2 0 Selenoprotein P, N terminal region SMYLE_N PF18615.1 ETO10034.1 - 0.37 10.3 15.4 3.6 7.0 9.5 2.1 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RPN2_C PF18004.1 ETO10034.1 - 0.78 9.6 13.4 1 9.3 8.2 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Herpes_pp85 PF04637.12 ETO10034.1 - 0.79 8.1 8.1 1.7 7.0 8.1 1.5 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Peptidase_S49_N PF08496.10 ETO10034.1 - 1.8 8.6 6.4 0.88 9.6 1.9 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Presenilin PF01080.17 ETO10034.1 - 2.8 6.6 13.2 0.036 12.8 2.5 2.1 2 0 0 2 2 2 0 Presenilin Zip PF02535.22 ETO10034.1 - 9.7 5.3 13.9 7.6 5.6 5.3 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter TMEM117 PF15113.6 ETO10035.1 - 0.0039 16.2 0.5 0.0041 16.1 0.5 1.0 1 0 0 1 1 1 1 TMEM117 protein family Peptidase_M16 PF00675.20 ETO10037.1 - 1.4e-14 54.3 0.2 2.8e-14 53.3 0.2 1.5 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) SDA1 PF05285.12 ETO10037.1 - 0.0015 18.0 13.7 0.0015 18.0 13.7 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO10037.1 - 0.043 12.0 15.5 0.055 11.7 15.5 1.4 1 0 0 1 1 1 0 Nop14-like family BSP_II PF05432.11 ETO10037.1 - 0.069 12.8 24.5 0.1 12.3 24.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Apt1 PF10351.9 ETO10037.1 - 0.077 11.8 5.6 0.068 12.0 5.6 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Presenilin PF01080.17 ETO10037.1 - 0.23 10.2 8.4 0.25 10.1 8.4 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO10037.1 - 0.25 9.8 3.2 0.22 10.0 3.2 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_S64 PF08192.11 ETO10037.1 - 1.4 7.3 6.7 1.5 7.2 6.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 ETO10037.1 - 2.5 7.0 4.5 2.7 6.9 4.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 BAF1_ABF1 PF04684.13 ETO10037.1 - 2.5 7.0 12.7 2.9 6.8 12.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor TFIIF_alpha PF05793.12 ETO10037.1 - 4.1 5.9 21.0 4.8 5.7 21.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) eIF-3c_N PF05470.12 ETO10037.1 - 8.2 4.6 13.6 10 4.3 13.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Mod_r PF07200.13 ETO10038.1 - 7.4e-11 42.4 9.2 2e-10 40.9 9.2 1.8 1 1 0 1 1 1 1 Modifier of rudimentary (Mod(r)) protein ZapB PF06005.12 ETO10038.1 - 0.024 15.1 0.4 0.024 15.1 0.4 2.1 2 1 0 2 2 2 0 Cell division protein ZapB BLOC1_2 PF10046.9 ETO10038.1 - 0.034 14.4 1.9 1.1 9.6 0.4 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 GTP_EFTU PF00009.27 ETO10038.1 - 0.054 13.0 2.8 0.48 9.9 2.8 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain ABC_tran_CTD PF16326.5 ETO10038.1 - 0.2 12.0 4.4 0.4 11.0 0.1 2.3 2 1 0 2 2 2 0 ABC transporter C-terminal domain Cytochrom_B562 PF07361.11 ETO10038.1 - 0.24 12.1 3.1 2.3 8.9 3.0 2.2 1 1 0 1 1 1 0 Cytochrome b562 Rho_Binding PF08912.11 ETO10038.1 - 0.8 10.6 7.5 9.1 7.2 0.2 3.2 2 1 0 2 2 2 0 Rho Binding Phage_HK97_TLTM PF06120.11 ETO10040.1 - 0.026 13.7 0.4 0.026 13.7 0.4 2.0 2 0 0 2 2 2 0 Tail length tape measure protein Sad1_UNC PF07738.13 ETO10043.1 - 4.2e-14 52.7 0.3 9.9e-13 48.3 0.2 2.8 2 1 0 2 2 2 1 Sad1 / UNC-like C-terminal DUF3810 PF12725.7 ETO10043.1 - 0.051 12.9 0.8 0.097 12.0 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) SlyX PF04102.12 ETO10043.1 - 0.092 13.4 5.7 6.8 7.4 0.1 3.6 3 0 0 3 3 3 0 SlyX SKA2 PF16740.5 ETO10043.1 - 0.16 11.8 2.6 0.63 9.8 0.8 2.5 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Fib_alpha PF08702.10 ETO10043.1 - 0.27 11.4 6.1 5.9 7.1 1.5 2.7 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Filament PF00038.21 ETO10043.1 - 0.31 10.6 5.3 7.2 6.1 0.1 2.2 2 0 0 2 2 2 0 Intermediate filament protein FliD_N PF02465.18 ETO10043.1 - 0.47 11.2 4.8 24 5.7 0.1 2.9 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Laminin_II PF06009.12 ETO10043.1 - 0.61 10.1 3.7 0.66 10.0 1.0 2.2 2 0 0 2 2 2 0 Laminin Domain II DUF4695 PF15766.5 ETO10043.1 - 1.2 9.4 4.4 2.6 8.3 0.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4695) TACC_C PF05010.14 ETO10044.1 - 0.0047 16.7 7.3 0.0047 16.7 7.3 1.9 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal RRF PF01765.19 ETO10044.1 - 0.0048 16.9 3.3 0.0048 16.9 3.3 1.7 2 0 0 2 2 2 1 Ribosome recycling factor Laminin_II PF06009.12 ETO10044.1 - 0.011 15.8 0.8 0.011 15.8 0.8 2.0 2 0 0 2 2 2 0 Laminin Domain II Fe-S_assembly PF04384.13 ETO10044.1 - 0.033 14.8 4.0 0.059 14.0 4.0 1.4 1 0 0 1 1 1 0 Iron-sulphur cluster assembly DUF1493 PF07377.12 ETO10044.1 - 0.13 12.7 1.5 0.29 11.6 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1493) T3SSipB PF16535.5 ETO10044.1 - 0.44 11.0 12.7 0.15 12.5 4.9 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB DUF3450 PF11932.8 ETO10044.1 - 6.6 6.0 13.6 0.72 9.1 8.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Neur_chan_memb PF02932.16 ETO10044.1 - 7.2 6.6 7.9 32 4.5 7.5 1.9 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ras PF00071.22 ETO10046.1 - 2e-45 154.3 0.0 2.8e-45 153.8 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO10046.1 - 4e-14 52.9 0.0 7.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO10046.1 - 1.4e-06 27.8 0.0 2.2e-06 27.3 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO10046.1 - 0.00063 19.3 0.0 0.0009 18.8 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO10046.1 - 0.0027 17.6 0.1 0.0061 16.5 0.1 1.6 2 0 0 2 2 2 1 RsgA GTPase Zemlya PF17646.1 ETO10047.1 - 0.0032 17.8 0.1 0.0096 16.3 0.1 1.8 1 0 0 1 1 1 1 Closterovirus 1a polyprotein central region RPM2 PF08579.11 ETO10048.1 - 0.028 14.8 0.2 0.033 14.6 0.2 1.1 1 0 0 1 1 1 0 Mitochondrial ribonuclease P subunit (RPM2) PI3K_1B_p101 PF10486.9 ETO10051.1 - 9.3e-12 43.6 0.2 1.8e-06 26.1 0.4 2.4 1 1 0 2 2 2 2 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pacs-1 PF10254.9 ETO10051.1 - 0.0084 15.1 0.1 0.0084 15.1 0.1 2.0 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein RLL PF10036.9 ETO10051.1 - 0.034 14.0 0.9 0.058 13.2 0.9 1.3 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Peptidase_M48 PF01435.18 ETO10052.1 - 4.4e-23 82.1 0.2 8.8e-23 81.1 0.2 1.4 1 1 0 1 1 1 1 Peptidase family M48 SprT-like PF10263.9 ETO10052.1 - 0.067 13.0 0.8 0.15 11.9 0.1 1.9 2 0 0 2 2 2 0 SprT-like family TMEM40 PF15817.5 ETO10052.1 - 0.097 12.4 1.4 0.32 10.8 0.0 2.4 2 0 0 2 2 2 0 Transmembrane protein 40 family DUF2828 PF11443.8 ETO10052.1 - 0.21 9.6 5.5 0.29 9.2 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Pkinase PF00069.25 ETO10053.1 - 3.4e-57 193.8 0.0 4.8e-57 193.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10053.1 - 1.7e-24 86.5 0.0 2.3e-24 86.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO10053.1 - 1.5e-20 71.1 10.1 2.3e-08 33.0 0.6 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO10053.1 - 2.5e-18 66.3 12.3 3.9e-10 40.1 0.4 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO10053.1 - 7.5e-14 50.4 17.1 1.4e-05 24.7 0.4 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ETO10053.1 - 8.6e-13 47.2 9.8 8.9e-07 28.1 0.4 3.9 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ETO10053.1 - 3.7e-09 36.3 12.8 0.0011 18.8 0.4 4.5 2 1 2 4 4 4 3 EF-hand domain pair APH PF01636.23 ETO10053.1 - 3.7e-05 23.8 0.1 0.00013 21.9 0.1 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO10053.1 - 4.6e-05 23.1 0.3 9.7e-05 22.0 0.3 1.5 1 0 0 1 1 1 1 RIO1 family SPARC_Ca_bdg PF10591.9 ETO10053.1 - 0.0021 18.4 1.9 0.66 10.3 0.1 3.2 1 1 2 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region Kdo PF06293.14 ETO10053.1 - 0.0078 15.6 0.1 0.017 14.5 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ETO10053.1 - 0.011 14.7 1.8 0.013 14.5 0.1 1.8 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Choline_kinase PF01633.20 ETO10053.1 - 0.013 15.1 2.2 0.024 14.2 0.2 2.2 2 2 0 2 2 2 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ETO10053.1 - 0.016 14.0 0.1 0.03 13.1 0.1 1.5 1 1 0 1 1 1 0 Fungal protein kinase EF-hand_4 PF12763.7 ETO10053.1 - 0.018 15.0 2.5 0.25 11.3 0.2 2.7 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand YrbL-PhoP_reg PF10707.9 ETO10053.1 - 0.032 13.8 0.0 0.07 12.6 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL LisH PF08513.11 ETO10053.1 - 0.15 12.1 0.0 0.37 10.8 0.0 1.7 1 0 0 1 1 1 0 LisH Arf PF00025.21 ETO10054.1 - 1.2e-05 24.9 0.0 1.6e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family XLF PF09302.11 ETO10055.1 - 2.6e-09 37.5 2.4 2.6e-09 37.5 2.4 3.4 3 2 1 4 4 4 1 XLF-Cernunnos, XRcc4-like factor, NHEJ component PepSY_TM PF03929.16 ETO10055.1 - 1.8 8.2 4.7 3.2 7.3 4.7 1.4 1 0 0 1 1 1 0 PepSY-associated TM region RTC4 PF14474.6 ETO10055.1 - 5.1 7.3 7.3 0.85 9.8 0.3 2.8 2 0 0 2 2 2 0 RTC4-like domain DUF3474 PF11960.8 ETO10056.1 - 0.11 12.8 0.3 0.11 12.8 0.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF3474) RNase_PH PF01138.21 ETO10056.1 - 3.2 8.3 5.9 13 6.3 0.6 2.8 2 0 0 2 2 2 0 3' exoribonuclease family, domain 1 Romo1 PF10247.9 ETO10057.1 - 0.56 10.6 4.7 3.6 8.0 0.5 2.4 2 0 0 2 2 2 0 Reactive mitochondrial oxygen species modulator 1 DSPc PF00782.20 ETO10058.1 - 3.7e-19 68.8 0.1 3.2e-18 65.8 0.0 2.2 1 1 2 3 3 3 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ETO10058.1 - 0.0013 19.0 0.1 0.0092 16.3 0.0 2.4 2 2 0 2 2 2 1 Rit1 DUSP-like domain Spore_III_AB PF09548.10 ETO10058.1 - 0.002 18.3 0.1 0.0046 17.1 0.1 1.6 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) Y_phosphatase PF00102.27 ETO10058.1 - 0.046 13.3 1.8 0.087 12.4 0.0 2.2 1 1 2 3 3 3 0 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETO10058.1 - 0.054 13.6 1.6 0.24 11.5 0.0 2.5 2 1 1 3 3 3 0 Inositol hexakisphosphate Gon7 PF08738.10 ETO10058.1 - 0.078 13.1 0.3 0.15 12.2 0.3 1.6 1 0 0 1 1 1 0 Gon7 family zf-C3HC4_3 PF13920.6 ETO10059.1 - 4.1e-08 32.9 9.1 4.1e-08 32.9 9.1 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAM_PNT PF02198.16 ETO10059.1 - 0.0012 18.8 0.4 0.0029 17.5 0.4 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 ETO10059.1 - 0.0015 18.6 1.8 0.005 16.9 1.8 1.9 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) FGF PF00167.18 ETO10059.1 - 0.003 17.7 0.0 0.11 12.5 0.0 2.4 1 1 1 2 2 2 1 Fibroblast growth factor Prok-RING_4 PF14447.6 ETO10059.1 - 0.0036 17.1 10.7 0.0036 17.1 10.7 2.2 3 0 0 3 3 2 1 Prokaryotic RING finger family 4 Fascin PF06268.13 ETO10059.1 - 0.02 15.1 0.4 0.069 13.4 0.2 2.0 1 1 0 1 1 1 0 Fascin domain SAM_1 PF00536.30 ETO10059.1 - 0.1 13.0 2.3 1.3 9.5 2.3 2.8 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) zf-RING_2 PF13639.6 ETO10059.1 - 0.14 12.5 11.3 0.53 10.7 11.3 2.1 1 0 0 1 1 1 0 Ring finger domain ATG16 PF08614.11 ETO10059.1 - 0.26 11.5 14.2 0.29 11.3 12.7 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 ETO10059.1 - 0.76 10.3 11.2 0.9 10.1 4.6 3.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 ETO10059.1 - 2.2 8.3 9.3 0.78 9.7 5.9 2.0 2 0 0 2 2 1 0 Laminin Domain II CLZ PF16526.5 ETO10059.1 - 2.8 8.4 13.5 1.8 9.0 5.6 3.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FlaC_arch PF05377.11 ETO10059.1 - 3.1 8.2 7.5 0.97 9.9 2.2 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF4140 PF13600.6 ETO10059.1 - 3.6 8.1 6.1 38 4.8 3.4 2.7 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) XhlA PF10779.9 ETO10059.1 - 4 7.7 13.6 0.7 10.1 5.4 2.7 2 0 0 2 2 2 0 Haemolysin XhlA Spc24 PF08286.11 ETO10059.1 - 4.4 7.6 10.7 1.9 8.8 5.2 2.9 2 1 0 2 2 2 0 Spc24 subunit of Ndc80 TMPIT PF07851.13 ETO10059.1 - 6.2 6.0 15.0 10 5.2 1.0 2.5 2 0 0 2 2 2 0 TMPIT-like protein DUF1664 PF07889.12 ETO10059.1 - 9.6 6.3 10.7 1.3 9.0 3.1 2.8 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2802 PF10975.8 ETO10060.1 - 0.055 13.6 0.3 0.099 12.8 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2802) PI3K_C2 PF00792.24 ETO10061.1 - 2.4e-07 30.7 0.6 0.00048 20.0 0.0 2.7 3 0 0 3 3 3 2 Phosphoinositide 3-kinase C2 PolyA_pol_arg_C PF12626.7 ETO10061.1 - 0.028 14.4 2.3 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Polymerase A arginine-rich C-terminus ETRAMP PF09716.10 ETO10061.1 - 0.48 10.5 3.9 7.8 6.6 0.0 3.1 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Usp PF00582.26 ETO10062.1 - 0.11 13.0 0.2 0.22 12.0 0.2 1.4 1 0 0 1 1 1 0 Universal stress protein family Macoilin PF09726.9 ETO10062.1 - 0.94 8.0 4.6 1 7.9 4.6 1.1 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO10062.1 - 2 6.6 5.0 2.1 6.6 5.0 1.0 1 0 0 1 1 1 0 Menin WD40 PF00400.32 ETO10064.1 - 8.3e-52 172.0 25.0 5e-10 39.8 0.2 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10064.1 - 1.8e-17 63.4 6.5 0.059 13.7 0.1 6.5 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10064.1 - 9e-08 31.4 2.9 0.056 12.4 0.1 4.1 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO10064.1 - 1.1e-07 31.5 4.2 0.00068 19.0 0.3 3.3 1 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO10064.1 - 4e-06 25.8 6.8 0.21 10.2 0.4 4.7 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO10064.1 - 0.00079 18.1 0.1 0.98 7.9 0.0 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO10064.1 - 0.004 17.0 0.0 8.4 6.5 0.0 3.6 5 0 0 5 5 5 2 PQQ enzyme repeat Me-amine-dh_H PF06433.11 ETO10064.1 - 0.011 14.6 0.1 24 3.6 0.0 3.4 1 1 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) Annexin PF00191.20 ETO10065.1 - 5.7e-21 74.4 5.7 2.8e-09 36.9 0.1 4.7 4 0 0 4 4 4 4 Annexin Kp4 PF09044.10 ETO10065.1 - 0.73 9.9 4.6 1.1 9.3 2.3 2.3 2 1 1 3 3 3 0 Kp4 LRR_6 PF13516.6 ETO10066.1 - 0.0002 21.1 5.7 4.6 7.6 0.1 4.5 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 ETO10066.1 - 0.008 16.6 0.7 33 5.6 0.0 4.5 3 1 0 3 3 3 1 Leucine Rich Repeat LRR_4 PF12799.7 ETO10066.1 - 0.58 10.7 9.3 6.6 7.3 0.9 4.1 3 1 2 5 5 5 0 Leucine Rich repeats (2 copies) zf-C3HC4 PF00097.25 ETO10067.1 - 8.9e-05 22.3 5.3 8.9e-05 22.3 5.3 4.7 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO10067.1 - 0.00011 22.1 6.9 0.00011 22.1 6.9 5.2 4 2 2 6 6 6 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETO10067.1 - 0.00038 20.7 29.6 0.009 16.3 3.4 3.8 3 0 0 3 3 3 3 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETO10067.1 - 0.0004 20.7 4.7 0.0004 20.7 4.7 4.5 3 1 0 3 3 3 1 Ring finger domain zf-RING_UBOX PF13445.6 ETO10067.1 - 0.00048 20.1 0.4 0.00048 20.1 0.4 4.0 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETO10067.1 - 0.0013 18.8 2.6 0.0013 18.8 2.6 5.2 6 0 0 6 6 6 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ETO10067.1 - 0.0047 16.8 5.7 0.0047 16.8 5.7 5.5 5 1 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO10067.1 - 0.015 15.2 2.6 0.015 15.2 2.6 3.9 3 1 0 3 3 3 0 Prokaryotic RING finger family 4 PBP1_TM PF14812.6 ETO10067.1 - 2.8 8.4 8.5 6.8 7.1 8.5 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CPSF100_C PF13299.6 ETO10067.1 - 8 6.6 8.2 7 6.8 4.1 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CrgA PF06781.12 ETO10068.1 - 0.14 12.3 1.6 0.63 10.1 0.0 2.6 3 0 0 3 3 3 0 Cell division protein CrgA SARAF PF06682.12 ETO10069.1 - 0.015 15.0 0.2 0.022 14.4 0.2 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF3740 PF12548.8 ETO10069.1 - 0.032 14.7 0.0 1.2 9.5 0.0 2.2 1 1 0 1 1 1 0 Sulfatase protein Cu-oxidase_3 PF07732.15 ETO10070.1 - 5.4e-07 29.7 0.9 1.3e-06 28.4 0.9 1.6 1 1 0 1 1 1 1 Multicopper oxidase Adaptin_N PF01602.20 ETO10071.1 - 2.1e-19 69.5 1.6 2.7e-19 69.1 1.6 1.1 1 0 0 1 1 1 1 Adaptin N terminal region KBP_C PF12309.8 ETO10071.1 - 0.00011 21.9 0.6 0.00013 21.7 0.6 1.0 1 0 0 1 1 1 1 KIF-1 binding protein C terminal GUN4_N PF16416.5 ETO10071.1 - 0.0094 15.9 0.1 0.019 14.9 0.1 1.5 1 0 0 1 1 1 1 ARM-like repeat domain, GUN4-N terminal DUF5109 PF17134.4 ETO10071.1 - 0.015 15.2 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5109) FMN_red PF03358.15 ETO10072.1 - 0.0043 16.8 0.0 0.0061 16.3 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase FSA_C PF10479.9 ETO10073.1 - 0.027 12.6 10.8 0.035 12.3 10.8 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FliP PF00813.20 ETO10073.1 - 0.21 11.4 0.4 0.3 11.0 0.4 1.2 1 0 0 1 1 1 0 FliP family Mucin PF01456.17 ETO10073.1 - 0.27 11.2 31.6 0.51 10.3 31.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein UL20 PF17582.2 ETO10073.1 - 2.5 7.3 12.0 4.3 6.5 12.0 1.4 1 0 0 1 1 1 0 Cytomegalovirus UL20 Dicty_REP PF05086.12 ETO10073.1 - 6.8 4.5 22.9 13 3.6 22.9 1.5 1 1 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Peptidase_U4 PF03419.13 ETO10074.1 - 0.68 9.2 9.2 1.1 8.5 9.2 1.2 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Prominin PF05478.11 ETO10074.1 - 2.9 5.7 7.6 5 5.0 7.6 1.3 1 0 0 1 1 1 0 Prominin DUF4191 PF13829.6 ETO10074.1 - 8.3 5.7 6.8 4 6.7 3.8 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4191) Cu-oxidase_2 PF07731.14 ETO10075.1 - 3e-13 49.7 0.2 6.6e-13 48.6 0.2 1.5 1 0 0 1 1 1 1 Multicopper oxidase CAP_GLY PF01302.25 ETO10076.1 - 5.5e-48 160.9 8.4 6.9e-26 90.1 0.4 3.0 3 0 0 3 3 3 2 CAP-Gly domain Bromodomain PF00439.25 ETO10079.1 - 8.6e-09 35.4 0.0 1.6e-08 34.5 0.0 1.5 1 0 0 1 1 1 1 Bromodomain Ribosomal_L18_c PF14204.6 ETO10079.1 - 4.9 8.2 6.6 2.5 9.1 0.2 2.6 3 0 0 3 3 3 0 Ribosomal L18 C-terminal region Zip PF02535.22 ETO10080.1 - 0.00041 19.7 0.3 0.00041 19.7 0.3 1.5 2 0 0 2 2 2 1 ZIP Zinc transporter Trypan_PARP PF05887.11 ETO10080.1 - 0.0055 16.7 11.7 0.0077 16.2 11.7 1.2 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) NPR3 PF03666.13 ETO10080.1 - 0.03 13.1 11.9 0.044 12.6 11.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3449 PF11931.8 ETO10080.1 - 0.2 11.4 12.0 0.91 9.3 12.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3449) Raftlin PF15250.6 ETO10080.1 - 0.5 9.1 4.3 0.59 8.8 4.3 1.1 1 0 0 1 1 1 0 Raftlin DUF5094 PF17015.5 ETO10080.1 - 1.7 8.7 10.3 2.9 8.0 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) MAP17 PF15807.5 ETO10080.1 - 2.9 8.1 8.2 6.2 7.1 8.2 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CDC45 PF02724.14 ETO10080.1 - 3.9 5.6 14.4 4.9 5.3 14.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO10080.1 - 4.4 6.6 21.8 5.5 6.3 21.8 1.1 1 0 0 1 1 1 0 SDA1 SAPS PF04499.15 ETO10080.1 - 8.9 5.0 11.7 11 4.6 11.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein PTPRCAP PF15713.5 ETO10080.1 - 9.5 6.5 18.3 14 6.0 18.3 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated BUD22 PF09073.10 ETO10082.1 - 0.97 8.7 47.4 1.2 8.4 47.4 1.1 1 0 0 1 1 1 0 BUD22 Raftlin PF15250.6 ETO10082.1 - 7.2 5.2 14.7 8.5 5.0 14.7 1.1 1 0 0 1 1 1 0 Raftlin Sulfatase PF00884.23 ETO10084.1 - 5.4e-57 193.5 0.9 6.7e-57 193.2 0.9 1.1 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ETO10084.1 - 3e-06 27.1 0.1 0.0036 16.9 0.0 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 ETO10084.1 - 0.023 13.8 0.0 0.031 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) tRNA-synt_1b PF00579.25 ETO10085.1 - 8e-24 84.5 0.0 1.9e-23 83.3 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) PH PF00169.29 ETO10085.1 - 4e-06 27.3 0.1 1.1e-05 25.9 0.1 1.8 1 0 0 1 1 1 1 PH domain PH_13 PF16652.5 ETO10085.1 - 0.0083 16.0 0.1 0.028 14.2 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 ETO10085.1 - 0.032 14.5 0.1 0.1 12.9 0.1 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain NOGCT PF08155.11 ETO10085.1 - 0.091 12.8 0.0 0.25 11.3 0.0 1.7 1 0 0 1 1 1 0 NOGCT (NUC087) domain ABC_tran_CTD PF16326.5 ETO10086.1 - 0.046 14.0 4.6 0.11 12.8 4.6 1.6 1 0 0 1 1 1 0 ABC transporter C-terminal domain SlyX PF04102.12 ETO10086.1 - 0.8 10.4 10.6 0.14 12.8 4.8 2.2 2 0 0 2 2 2 0 SlyX FAM76 PF16046.5 ETO10086.1 - 2.7 7.3 15.0 0.4 10.0 6.7 2.0 2 0 0 2 2 2 0 FAM76 protein DUF3450 PF11932.8 ETO10086.1 - 3.3 7.0 16.2 1.2 8.4 9.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Spc7 PF08317.11 ETO10086.1 - 9.7 5.0 19.8 0.29 10.0 10.6 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein ERp29 PF07749.12 ETO10087.1 - 3.2e-25 88.9 0.8 5.5e-25 88.1 0.8 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain ERp29_N PF07912.13 ETO10087.1 - 7.9e-08 32.5 0.1 2.1e-07 31.1 0.0 1.8 2 0 0 2 2 2 1 ERp29, N-terminal domain Hydrolase_4 PF12146.8 ETO10088.1 - 0.0024 17.2 0.0 0.027 13.7 0.1 1.9 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_5 PF12695.7 ETO10088.1 - 0.016 15.0 0.0 0.077 12.8 0.0 2.0 2 1 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 ETO10088.1 - 0.1 13.2 0.0 0.13 12.9 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family WW PF00397.26 ETO10089.1 - 1.6 8.9 4.9 2.9 8.1 4.9 1.4 1 0 0 1 1 1 0 WW domain YMF19 PF02326.15 ETO10090.1 - 0.022 15.5 0.6 0.022 15.5 0.6 1.8 2 0 0 2 2 2 0 Plant ATP synthase F0 O-antigen_lig PF13425.6 ETO10090.1 - 0.023 13.5 1.0 0.037 12.8 1.0 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein UNC80 PF15778.5 ETO10090.1 - 0.072 12.7 0.2 1.4 8.5 0.1 2.3 2 0 0 2 2 2 0 Cation channel complex component UNC80 Myc_target_1 PF15179.6 ETO10090.1 - 0.14 12.1 0.0 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 Myc target protein 1 SerH PF06873.11 ETO10090.1 - 0.29 9.9 1.3 0.47 9.2 1.3 1.3 1 0 0 1 1 1 0 Cell surface immobilisation antigen SerH C2 PF00168.30 ETO10091.1 - 5.5e-13 49.1 0.1 1.5e-12 47.7 0.1 1.7 1 0 0 1 1 1 1 C2 domain PDZ_6 PF17820.1 ETO10091.1 - 0.00027 20.7 0.0 0.00076 19.3 0.0 1.8 2 0 0 2 2 2 1 PDZ domain UBA PF00627.31 ETO10091.1 - 0.00031 20.6 0.0 0.00098 19.0 0.0 1.8 2 0 0 2 2 2 1 UBA/TS-N domain Agenet PF05641.12 ETO10091.1 - 0.047 14.2 0.4 0.23 12.0 0.2 2.4 2 0 0 2 2 2 0 Agenet domain zf-RanBP PF00641.18 ETO10091.1 - 0.2 11.0 1.8 0.42 10.0 1.8 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Acetyltransf_18 PF18014.1 ETO10092.1 - 0.035 14.0 0.1 0.046 13.6 0.1 1.3 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Thioredoxin_8 PF13905.6 ETO10092.1 - 0.16 12.3 1.4 0.21 11.9 1.2 1.5 1 1 0 1 1 1 0 Thioredoxin-like SF1-HH PF16275.5 ETO10094.1 - 3.2e-21 75.8 1.8 4.4e-21 75.3 0.3 2.0 2 0 0 2 2 2 1 Splicing factor 1 helix-hairpin domain KH_1 PF00013.29 ETO10094.1 - 8.4e-06 25.5 0.2 3.6e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 KH domain zf-CCHC PF00098.23 ETO10094.1 - 0.12 12.5 8.5 1.5 9.1 1.6 2.5 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 ETO10094.1 - 0.13 12.3 4.2 0.64 10.0 0.0 2.4 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 ETO10094.1 - 0.51 10.1 7.7 3.7 7.3 0.5 2.4 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_6 PF15288.6 ETO10094.1 - 1.6 8.6 5.7 5.8 6.8 5.4 2.2 1 1 1 2 2 2 0 Zinc knuckle Apt1 PF10351.9 ETO10096.1 - 0.00071 18.6 6.9 0.00071 18.6 6.9 2.2 2 0 0 2 2 2 1 Golgi-body localisation protein domain SAPS PF04499.15 ETO10096.1 - 0.19 10.4 24.5 0.68 8.6 8.0 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein LAP1C PF05609.12 ETO10096.1 - 0.52 9.4 27.2 0.099 11.7 8.1 2.2 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) TonB_N PF16031.5 ETO10096.1 - 0.66 10.5 12.3 1.6 9.2 12.3 1.6 1 0 0 1 1 1 0 TonB polyproline region DUF1189 PF06691.11 ETO10096.1 - 1.1 8.7 0.0 1.1 8.7 0.0 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1189) Hid1 PF12722.7 ETO10096.1 - 1.5 6.9 27.9 0.014 13.5 8.7 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 ETO10096.1 - 2.1 6.5 28.4 0.29 9.4 13.5 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF2052 PF09747.9 ETO10096.1 - 4.2 7.5 31.0 6.6 6.8 17.7 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Spore_coat_CotO PF14153.6 ETO10096.1 - 8.4 6.3 26.9 0.17 11.8 14.6 2.2 2 0 0 2 2 2 0 Spore coat protein CotO Vfa1 PF08432.10 ETO10096.1 - 9.3 6.5 35.6 5.1 7.4 4.4 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 MGDG_synth PF06925.11 ETO10097.1 - 0.1 12.7 0.1 0.16 12.1 0.1 1.3 1 0 0 1 1 1 0 Monogalactosyldiacylglycerol (MGDG) synthase RRM_1 PF00076.22 ETO10098.1 - 0.0015 18.3 0.0 0.028 14.2 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF188 PF02639.14 ETO10098.1 - 0.13 12.0 0.2 4.9 6.8 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized BCR, YaiI/YqxD family COG1671 Acyltransferase PF01553.21 ETO10099.1 - 2.6e-11 43.3 0.2 7.2e-11 41.8 0.0 1.8 2 0 0 2 2 2 1 Acyltransferase Cnd1_N PF12922.7 ETO10099.1 - 0.017 15.0 0.2 0.017 15.0 0.2 2.2 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term DUF4064 PF13273.6 ETO10099.1 - 0.1 12.9 1.2 8.7 6.7 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Ctr PF04145.15 ETO10100.1 - 0.16 12.6 0.7 0.24 12.0 0.1 1.6 2 0 0 2 2 2 0 Ctr copper transporter family YL1 PF05764.13 ETO10101.1 - 0.0067 16.6 33.5 0.0098 16.0 33.5 1.3 1 0 0 1 1 1 1 YL1 nuclear protein EELM2 PF15863.5 ETO10102.1 - 0.053 13.6 0.0 0.085 13.0 0.0 1.3 1 0 0 1 1 1 0 Extended EGL-27 and MTA1 homology domain PAXIP1_C PF15364.6 ETO10102.1 - 0.21 11.9 0.1 0.21 11.9 0.1 2.1 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein F-box PF00646.33 ETO10104.1 - 0.94 9.4 5.0 2.6 8.0 3.2 2.4 2 1 0 2 2 2 0 F-box domain Ins134_P3_kin_N PF17927.1 ETO10105.1 - 2.1e-09 37.7 0.0 5.1e-09 36.4 0.0 1.7 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain ETRAMP PF09716.10 ETO10105.1 - 7.3e-05 22.8 2.7 0.11 12.6 0.1 2.8 2 1 0 2 2 2 2 Malarial early transcribed membrane protein (ETRAMP) Ost5 PF05251.12 ETO10105.1 - 0.019 15.2 0.5 0.054 13.8 0.5 1.8 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 Herpes_capsid PF06112.11 ETO10106.1 - 4.9 7.2 9.8 6.1 6.9 9.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein PH PF00169.29 ETO10107.1 - 0.0079 16.7 0.0 0.013 16.0 0.0 1.4 1 0 0 1 1 1 1 PH domain Sigma70_ner PF04546.13 ETO10107.1 - 0.17 11.7 3.6 0.28 11.1 3.6 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Mem_trans PF03547.18 ETO10107.1 - 0.46 8.8 1.8 0.63 8.4 1.8 1.1 1 0 0 1 1 1 0 Membrane transport protein Mg_trans_NIPA PF05653.14 ETO10108.1 - 1.3e-06 27.8 4.6 1e-05 24.8 0.1 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA Cu-oxidase_2 PF07731.14 ETO10109.1 - 3e-09 36.7 1.1 7.7e-09 35.4 1.1 1.6 1 1 0 1 1 1 1 Multicopper oxidase CAP_GLY PF01302.25 ETO10110.1 - 2.1e-22 78.9 4.0 6.9e-21 74.0 0.4 3.0 4 0 0 4 4 4 2 CAP-Gly domain DUF5305 PF17231.2 ETO10110.1 - 0.018 14.4 0.1 0.041 13.3 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Chorion_2 PF03964.15 ETO10110.1 - 0.059 14.2 6.2 0.24 12.2 6.2 2.0 1 0 0 1 1 1 0 Chorion family 2 DUF3149 PF11346.8 ETO10110.1 - 1.8 8.3 4.7 4.6 6.9 4.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) 4HBT PF03061.22 ETO10111.1 - 1.7e-10 41.1 0.0 3.2e-10 40.2 0.0 1.4 1 0 0 1 1 1 1 Thioesterase superfamily PIG-H PF10181.9 ETO10111.1 - 0.056 13.3 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 GPI-GlcNAc transferase complex, PIG-H component 2OG-FeII_Oxy_3 PF13640.6 ETO10112.1 - 1.4e-05 25.9 0.0 2.6e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TauD PF02668.16 ETO10112.1 - 0.02 14.7 0.1 0.065 13.0 0.0 1.8 2 1 0 2 2 2 0 Taurine catabolism dioxygenase TauD, TfdA family KNTase_C PF07827.11 ETO10112.1 - 0.14 12.0 0.0 5 7.0 0.0 2.4 1 1 1 2 2 2 0 KNTase C-terminal domain Exo_endo_phos PF03372.23 ETO10113.1 - 0.043 13.3 0.0 0.048 13.2 0.0 1.1 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Npun_R1517 PF18068.1 ETO10113.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Npun R1517 NOA36 PF06524.12 ETO10114.1 - 0.0049 16.2 2.4 0.0063 15.9 2.4 1.2 1 0 0 1 1 1 1 NOA36 protein Phage_holin_3_6 PF07332.11 ETO10114.1 - 0.14 12.2 0.0 0.21 11.6 0.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III AMP-binding PF00501.28 ETO10115.1 - 1.3e-14 53.6 0.0 2e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme YMF19 PF02326.15 ETO10115.1 - 9 7.2 9.9 16 6.4 0.7 2.5 2 0 0 2 2 2 0 Plant ATP synthase F0 C2 PF00168.30 ETO10117.1 - 4.7e-14 52.5 0.0 1.5e-13 50.9 0.0 1.9 1 0 0 1 1 1 1 C2 domain Spo0A_C PF08769.11 ETO10117.1 - 0.018 15.2 0.0 0.18 11.9 0.0 2.8 2 0 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal ATPgrasp_Ter PF15632.6 ETO10117.1 - 0.11 12.3 0.0 0.35 10.6 0.0 1.9 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon TFIIA PF03153.13 ETO10118.1 - 0.00023 21.3 11.8 0.00023 21.3 11.8 3.3 2 1 0 3 3 3 1 Transcription factor IIA, alpha/beta subunit SpoIIIAH PF12685.7 ETO10118.1 - 0.0066 16.3 2.8 0.0066 16.3 2.8 5.3 3 2 1 4 4 4 1 SpoIIIAH-like protein CRA PF06589.11 ETO10118.1 - 0.014 15.5 2.6 0.014 15.5 2.6 5.7 4 1 0 4 4 4 0 Circumsporozoite-related antigen (CRA) MLANA PF14991.6 ETO10118.1 - 0.23 11.7 2.9 1.3 9.3 0.0 3.1 2 0 0 2 2 2 0 Protein melan-A TPR_12 PF13424.6 ETO10119.1 - 0.00025 21.3 0.0 0.00044 20.5 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10119.1 - 0.027 14.3 0.1 0.38 10.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10119.1 - 0.033 14.4 0.0 0.21 11.9 0.0 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10119.1 - 0.097 12.8 0.0 0.73 10.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Pkinase PF00069.25 ETO10120.1 - 0.0037 16.7 0.1 0.0081 15.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain KA1 PF02149.19 ETO10120.1 - 0.042 13.6 0.1 0.099 12.5 0.1 1.6 1 0 0 1 1 1 0 Kinase associated domain 1 Chromo PF00385.24 ETO10121.1 - 5.5e-15 55.0 0.8 1.3e-14 53.8 0.8 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Mucin PF01456.17 ETO10122.1 - 0.14 12.1 8.1 0.2 11.7 8.1 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DHHC PF01529.20 ETO10123.1 - 2.2e-36 124.9 11.5 2.2e-36 124.9 11.5 2.4 2 1 0 2 2 2 1 DHHC palmitoyltransferase YgbA_NO PF11756.8 ETO10124.1 - 0.032 14.6 2.2 0.032 14.6 2.2 1.8 2 0 0 2 2 2 0 Nitrous oxide-stimulated promoter Fer4_14 PF13394.6 ETO10125.1 - 0.014 15.5 0.1 0.033 14.3 0.1 1.7 1 0 0 1 1 1 0 4Fe-4S single cluster domain DisA-linker PF10635.9 ETO10125.1 - 0.021 14.6 0.1 0.021 14.6 0.1 2.2 3 1 0 3 3 3 0 DisA bacterial checkpoint controller linker region Mrr_N PF14338.6 ETO10125.1 - 0.026 14.7 1.9 1.6 8.9 0.0 3.3 2 1 1 3 3 3 0 Mrr N-terminal domain Laminin_I PF06008.14 ETO10125.1 - 0.032 13.9 3.1 0.054 13.2 3.1 1.4 1 0 0 1 1 1 0 Laminin Domain I FAM184 PF15665.5 ETO10125.1 - 0.13 12.0 10.0 0.4 10.4 10.0 1.8 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B SAS4 PF15460.6 ETO10127.1 - 0.0037 17.3 0.2 0.0061 16.6 0.2 1.4 1 0 0 1 1 1 1 Something about silencing, SAS, complex subunit 4 LRR_6 PF13516.6 ETO10127.1 - 0.014 15.4 0.6 0.044 13.8 0.1 2.1 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 ETO10127.1 - 0.14 12.6 2.1 0.61 10.6 0.4 2.6 1 1 1 2 2 2 0 Leucine Rich repeats (2 copies) Ctr PF04145.15 ETO10129.1 - 0.065 13.9 0.8 0.12 13.0 0.2 1.7 2 0 0 2 2 2 0 Ctr copper transporter family TFIIF_alpha PF05793.12 ETO10132.1 - 3.5 6.1 59.2 4.8 5.7 59.2 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_circ_N PF07157.12 ETO10133.1 - 0.018 15.4 0.3 0.052 13.9 0.1 1.7 1 1 1 2 2 2 0 DNA circularisation protein N-terminus Synaptonemal_3 PF15191.6 ETO10134.1 - 0.061 13.1 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 Synaptonemal complex central element protein 3 FF PF01846.19 ETO10136.1 - 0.0001 22.4 0.1 0.0001 22.4 0.1 3.0 3 1 1 4 4 4 1 FF domain ETRAMP PF09716.10 ETO10136.1 - 0.0027 17.7 0.3 0.0027 17.7 0.3 2.3 1 1 1 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) Csm2_III-A PF03750.13 ETO10136.1 - 0.022 15.6 6.0 0.029 15.2 1.6 2.2 2 0 0 2 2 2 0 Csm2 Type III-A Tiam_CC_Ex PF18385.1 ETO10136.1 - 0.023 15.1 0.3 0.023 15.1 0.3 1.8 1 1 1 2 2 2 0 T-lymphoma invasion and metastasis CC-Ex domain Peptidase_Prp PF04327.12 ETO10136.1 - 0.039 14.2 1.5 0.057 13.7 0.7 1.7 1 1 1 2 2 2 0 Cysteine protease Prp XFP PF03894.15 ETO10136.1 - 0.12 12.1 1.2 0.13 12.0 0.3 1.6 2 0 0 2 2 2 0 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase HA2 PF04408.23 ETO10136.1 - 0.37 11.1 3.0 14 6.0 0.1 2.2 2 0 0 2 2 2 0 Helicase associated domain (HA2) DUF3671 PF12420.8 ETO10136.1 - 1 9.5 7.1 0.52 10.4 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function RNA_pol_Rpb1_4 PF05000.17 ETO10136.1 - 1 9.3 5.9 1.1 9.2 1.9 2.1 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 4 DUF5345 PF17280.2 ETO10136.1 - 2.9 8.0 6.8 0.2 11.6 1.4 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5345) FF PF01846.19 ETO10137.1 - 2.5e-13 49.9 6.1 3.6e-11 43.1 0.4 2.9 2 1 0 2 2 2 2 FF domain HEPPP_synt_1 PF07307.11 ETO10137.1 - 0.031 13.9 6.1 0.043 13.4 6.1 1.1 1 0 0 1 1 1 0 Heptaprenyl diphosphate synthase (HEPPP synthase) subunit 1 DUF445 PF04286.12 ETO10137.1 - 0.49 10.2 4.9 0.57 9.9 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) ZZ PF00569.17 ETO10138.1 - 0.19 11.6 3.7 0.43 10.4 3.7 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type CPSF100_C PF13299.6 ETO10138.1 - 0.2 11.8 10.8 11 6.2 3.9 3.3 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal SAPS PF04499.15 ETO10138.1 - 0.45 9.2 14.3 0.0093 14.8 4.9 2.0 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Zip PF02535.22 ETO10138.1 - 2.6 7.2 15.7 4.4 6.4 0.2 2.3 2 1 0 2 2 2 0 ZIP Zinc transporter Cwf_Cwc_15 PF04889.12 ETO10138.1 - 2.9 7.5 25.1 24 4.6 0.1 2.8 2 1 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein HATPase_c PF02518.26 ETO10139.1 - 4.9e-13 49.6 0.0 1.1e-12 48.5 0.0 1.6 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO10139.1 - 0.00016 21.5 0.0 0.00026 20.8 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase YMF19 PF02326.15 ETO10140.1 - 0.096 13.5 1.0 0.096 13.5 1.0 2.3 2 2 0 2 2 2 0 Plant ATP synthase F0 CH PF00307.31 ETO10141.1 - 2.6e-06 27.6 2.0 5.9e-06 26.4 0.1 2.7 2 0 0 2 2 2 1 Calponin homology (CH) domain Fez1 PF06818.15 ETO10141.1 - 0.00022 21.8 13.9 0.00022 21.8 13.9 3.6 1 1 2 3 3 3 2 Fez1 CEP63 PF17045.5 ETO10141.1 - 0.0042 17.0 29.0 0.0042 17.0 29.0 2.6 1 1 1 2 2 1 1 Centrosomal protein of 63 kDa DivIC PF04977.15 ETO10141.1 - 0.0044 16.7 4.2 0.0044 16.7 4.2 7.6 5 2 4 9 9 9 1 Septum formation initiator TSC22 PF01166.18 ETO10141.1 - 0.015 15.6 0.8 0.015 15.6 0.8 5.2 5 1 0 5 5 5 0 TSC-22/dip/bun family Shugoshin_N PF07558.11 ETO10141.1 - 0.058 13.3 0.6 0.058 13.3 0.6 4.0 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region GBR2_CC PF18455.1 ETO10141.1 - 0.36 11.0 4.5 8.1 6.7 0.3 3.7 3 0 0 3 3 3 0 Gamma-aminobutyric acid type B receptor subunit 2 coiled-coil domain TPR_MLP1_2 PF07926.12 ETO10141.1 - 2.4 8.2 60.6 0.51 10.4 11.8 5.5 2 2 2 4 4 4 0 TPR/MLP1/MLP2-like protein Baculo_PEP_C PF04513.12 ETO10141.1 - 3.1 7.8 13.9 0.4 10.7 0.8 3.5 2 2 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 ETO10141.1 - 3.3 5.1 54.8 0.5 7.8 33.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Filament PF00038.21 ETO10141.1 - 6.1 6.3 58.1 7.2 6.1 5.6 3.3 1 1 1 2 2 2 0 Intermediate filament protein CENP-F_leu_zip PF10473.9 ETO10141.1 - 9.5 6.2 57.8 0.031 14.3 30.1 3.7 2 2 1 3 3 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Laminin_II PF06009.12 ETO10141.1 - 9.7 6.2 29.5 0.091 12.8 1.0 4.3 2 1 2 4 4 4 0 Laminin Domain II Lung_7-TM_R PF06814.13 ETO10142.1 - 1.3e-56 192.0 24.1 2.7e-56 191.0 24.1 1.5 1 1 0 1 1 1 1 Lung seven transmembrane receptor TRAP_alpha PF03896.16 ETO10142.1 - 0.0067 15.7 0.9 0.01 15.0 0.9 1.2 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit Spo7 PF03907.13 ETO10142.1 - 0.77 9.2 13.2 0.033 13.7 3.6 2.4 2 0 0 2 2 2 0 Spo7-like protein FAM176 PF14851.6 ETO10142.1 - 0.87 9.2 8.5 0.95 9.1 0.0 2.5 1 1 1 2 2 2 0 FAM176 family Pes-10 PF07149.11 ETO10142.1 - 3.4 6.6 7.6 5.1 6.1 7.6 1.2 1 0 0 1 1 1 0 Pes-10 DUF3671 PF12420.8 ETO10142.1 - 6.3 6.9 8.3 12 6.0 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function TPR_2 PF07719.17 ETO10143.1 - 0.0097 16.0 2.6 0.025 14.7 0.1 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat Spt20 PF12090.8 ETO10143.1 - 0.018 14.7 26.6 0.028 14.1 26.6 1.5 1 0 0 1 1 1 0 Spt20 family LMBR1 PF04791.16 ETO10143.1 - 0.027 13.4 6.4 0.04 12.8 6.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TPR_1 PF00515.28 ETO10143.1 - 0.029 14.2 1.6 0.054 13.3 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Glyco_transf_4 PF13439.6 ETO10143.1 - 0.12 12.4 0.1 0.17 11.9 0.1 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 PepSY_TM PF03929.16 ETO10143.1 - 0.13 11.9 1.0 0.15 11.7 1.0 1.2 1 0 0 1 1 1 0 PepSY-associated TM region MMR1 PF08505.10 ETO10143.1 - 0.19 12.0 16.1 0.24 11.6 16.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein TFIIA PF03153.13 ETO10143.1 - 0.68 9.9 25.4 0.83 9.6 25.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 ETO10143.1 - 2.6 6.2 13.8 3 6.0 13.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO10143.1 - 3 6.5 15.1 3.9 6.1 15.1 1.3 1 0 0 1 1 1 0 Presenilin TPR_2 PF07719.17 ETO10144.1 - 3.4e-14 51.7 29.1 0.015 15.4 0.0 9.5 11 0 0 11 11 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO10144.1 - 7.8e-13 48.5 12.2 0.15 12.3 0.0 6.6 6 1 1 7 7 6 6 Tetratricopeptide repeat TPR_19 PF14559.6 ETO10144.1 - 4.5e-11 43.1 11.6 6.4e-06 26.6 0.1 6.4 4 1 1 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10144.1 - 1.4e-10 40.5 25.2 0.028 14.6 0.1 8.7 9 1 1 10 10 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO10144.1 - 2.2e-10 41.0 0.0 0.00029 21.4 0.0 5.3 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10144.1 - 2.7e-10 39.8 1.0 0.14 11.9 0.0 5.8 4 1 1 5 5 5 3 TPR repeat TPR_14 PF13428.6 ETO10144.1 - 4.4e-10 39.5 3.4 0.083 13.7 0.0 6.6 5 1 2 7 7 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10144.1 - 7.5e-10 38.2 22.1 0.057 13.3 0.2 7.8 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO10144.1 - 1.7e-09 37.4 10.1 0.018 15.4 0.0 6.9 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10144.1 - 1.4e-07 31.0 5.0 1.7 8.9 0.1 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO10144.1 - 0.0025 18.1 3.7 0.03 14.7 0.0 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10144.1 - 0.0026 17.6 13.2 0.13 12.2 0.0 6.1 7 0 0 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO10144.1 - 0.0036 17.5 0.2 0.0036 17.5 0.2 4.8 3 2 1 5 5 4 2 Anaphase-promoting complex, cyclosome, subunit 3 DDHD PF02862.17 ETO10144.1 - 0.0054 16.9 1.7 0.0081 16.3 1.7 1.4 1 0 0 1 1 1 1 DDHD domain CobT PF06213.12 ETO10144.1 - 0.0066 15.9 6.7 0.011 15.2 6.7 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT TERB2 PF15101.6 ETO10144.1 - 0.015 15.3 7.3 0.035 14.1 7.3 1.6 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Band_3_cyto PF07565.13 ETO10144.1 - 0.038 13.8 1.5 0.054 13.3 1.5 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2722 PF10846.8 ETO10144.1 - 0.046 12.7 11.9 0.065 12.2 11.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TPR_9 PF13371.6 ETO10144.1 - 0.13 12.5 0.2 2.5 8.3 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 ETO10144.1 - 0.17 12.0 8.6 1 9.4 8.3 2.3 1 1 1 2 2 2 0 MAS20 protein import receptor Presenilin PF01080.17 ETO10144.1 - 0.19 10.5 4.8 0.3 9.8 4.8 1.2 1 0 0 1 1 1 0 Presenilin Spt20 PF12090.8 ETO10144.1 - 1.1 8.9 17.5 0.17 11.5 13.4 1.7 2 0 0 2 2 2 0 Spt20 family TPR_6 PF13174.6 ETO10144.1 - 2 9.3 10.0 5.2 7.9 0.0 5.2 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF4834 PF16118.5 ETO10144.1 - 2.7 9.0 11.7 1.7 9.6 8.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF5327 PF17261.2 ETO10144.1 - 8.7 7.2 14.8 45 4.9 14.8 2.2 1 1 0 1 1 1 0 Family of unknown function (DUF5327) RhoGEF PF00621.20 ETO10145.1 - 5e-13 49.7 2.1 5e-13 49.7 2.1 1.9 2 1 0 2 2 2 1 RhoGEF domain DUF4859 PF16151.5 ETO10148.1 - 0.037 13.9 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4859) Asp_protease PF09668.10 ETO10149.1 - 1.4e-20 73.3 0.8 2.2e-09 37.1 0.2 2.3 1 1 1 2 2 2 2 Aspartyl protease FSA_C PF10479.9 ETO10149.1 - 0.00063 18.0 14.1 0.00087 17.6 14.1 1.2 1 0 0 1 1 1 1 Fragile site-associated protein C-terminus UBA_4 PF14555.6 ETO10149.1 - 0.0044 16.8 0.0 0.012 15.4 0.0 1.7 1 0 0 1 1 1 1 UBA-like domain UBA PF00627.31 ETO10149.1 - 0.044 13.7 0.2 0.082 12.8 0.2 1.5 1 0 0 1 1 1 0 UBA/TS-N domain SOG2 PF10428.9 ETO10149.1 - 0.18 10.9 21.0 0.23 10.6 21.0 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 ETO10149.1 - 0.29 10.0 11.2 0.39 9.5 11.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ETO10149.1 - 1 7.8 10.4 1.5 7.3 10.4 1.1 1 0 0 1 1 1 0 Macoilin family Tmemb_cc2 PF10267.9 ETO10149.1 - 5.7 6.0 9.0 7.8 5.5 9.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein TTL PF03133.15 ETO10150.1 - 1.6e-30 106.3 1.1 2.3e-30 105.7 1.1 1.2 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_ST PF14397.6 ETO10150.1 - 0.034 13.4 0.0 0.065 12.5 0.0 1.4 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp TTL PF03133.15 ETO10151.1 - 1.3e-21 77.1 0.0 2.5e-21 76.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family DUSP PF06337.12 ETO10152.1 - 2.6e-19 69.6 0.1 2.6e-19 69.6 0.1 2.9 3 0 0 3 3 3 1 DUSP domain SID-1_RNA_chan PF13965.6 ETO10152.1 - 0.00066 18.2 0.7 0.0012 17.4 0.7 1.3 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 ETO10152.1 - 0.014 13.4 0.6 0.028 12.4 0.6 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Hep_59 PF07052.11 ETO10152.1 - 0.016 15.9 0.6 0.016 15.9 0.6 2.7 3 0 0 3 3 2 0 Hepatocellular carcinoma-associated antigen 59 OATP PF03137.20 ETO10152.1 - 0.036 12.4 0.0 0.062 11.6 0.0 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4199 PF13858.6 ETO10152.1 - 0.078 13.4 0.5 0.49 10.8 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) TssO PF17561.2 ETO10152.1 - 0.11 12.6 7.3 0.052 13.7 3.5 2.2 2 0 0 2 2 2 0 Type VI secretion system, TssO FHIPEP PF00771.20 ETO10152.1 - 0.12 10.8 0.3 0.22 9.9 0.3 1.3 1 0 0 1 1 1 0 FHIPEP family DUF4834 PF16118.5 ETO10152.1 - 0.23 12.5 0.3 0.23 12.5 0.3 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) O-antigen_lig PF13425.6 ETO10152.1 - 0.26 10.0 1.5 0.46 9.2 1.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Mucin PF01456.17 ETO10152.1 - 0.6 10.1 49.3 13 5.7 9.4 4.0 4 0 0 4 4 4 0 Mucin-like glycoprotein DUF4094 PF13334.6 ETO10152.1 - 1.4 9.4 5.0 0.32 11.5 0.3 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4094) UPF0239 PF06783.11 ETO10152.1 - 2.6 8.3 6.7 1.7 8.9 0.1 3.7 4 1 0 4 4 3 0 Uncharacterised protein family (UPF0239) RLL PF10036.9 ETO10152.1 - 5.6 6.7 13.5 0.51 10.1 3.5 2.7 3 1 0 3 3 3 0 RNA transcription, translation and transport factor protein Kei1 PF08552.11 ETO10152.1 - 5.9 6.7 11.3 1.6 8.6 0.0 3.3 3 0 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 YlbD_coat PF14071.6 ETO10152.1 - 8.1 6.7 15.5 7.3 6.9 7.4 3.3 3 0 0 3 3 3 0 Putative coat protein Mob1_phocein PF03637.17 ETO10153.1 - 8.8e-79 263.4 0.1 1.2e-78 262.9 0.1 1.2 1 0 0 1 1 1 1 Mob1/phocein family MKT1_N PF12247.8 ETO10154.1 - 0.12 12.7 0.0 0.51 10.7 0.0 2.1 1 0 0 1 1 1 0 Temperature dependent protein affecting M2 dsRNA replication TRAPPC-Trs85 PF12739.7 ETO10155.1 - 1.9e-39 135.8 0.3 2.3e-39 135.6 0.3 1.1 1 0 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit TPR_12 PF13424.6 ETO10155.1 - 0.15 12.4 0.6 0.3 11.4 0.6 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4833 PF16117.5 ETO10156.1 - 9.6e-34 116.4 0.0 1.1e-33 116.2 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4833) Xol-1_GHMP-like PF09109.10 ETO10156.1 - 0.14 12.0 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like Exo_endo_phos PF03372.23 ETO10157.1 - 0.0012 18.4 0.0 0.0015 18.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VHP PF02209.19 ETO10157.1 - 2.6 8.2 7.8 0.14 12.3 1.5 2.2 2 0 0 2 2 2 0 Villin headpiece domain RhoGAP PF00620.27 ETO10158.1 - 3e-15 56.4 0.0 5.3e-15 55.6 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain TPR_2 PF07719.17 ETO10160.1 - 0.0003 20.7 0.1 1.4 9.2 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO10160.1 - 0.0015 18.8 0.0 1.5 9.2 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO10160.1 - 0.0022 18.2 0.0 0.037 14.2 0.0 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETO10160.1 - 0.0065 16.6 0.1 1.1 9.6 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat Presenilin PF01080.17 ETO10160.1 - 9.3 4.9 6.4 13 4.4 6.4 1.2 1 0 0 1 1 1 0 Presenilin RGS PF00615.19 ETO10161.1 - 0.00081 19.6 0.1 0.0045 17.2 0.0 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain YmzC PF14157.6 ETO10161.1 - 0.24 11.5 0.8 1.9 8.6 0.1 2.3 2 0 0 2 2 2 0 YmzC-like protein DUF4105 PF13387.6 ETO10162.1 - 0.046 13.4 1.3 0.062 12.9 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) TPT PF03151.16 ETO10163.1 - 1.4e-14 54.1 7.3 1.8e-14 53.8 7.3 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ETO10163.1 - 2.2e-05 23.9 7.2 2.9e-05 23.4 7.2 1.1 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO10163.1 - 0.00016 21.9 9.4 0.00024 21.3 9.4 1.2 1 0 0 1 1 1 1 EamA-like transporter family Zn_peptidase_2 PF04298.12 ETO10163.1 - 0.0032 16.9 0.4 0.0032 16.9 0.4 1.7 2 0 0 2 2 2 1 Putative neutral zinc metallopeptidase DUF5336 PF17270.2 ETO10163.1 - 0.015 14.9 1.1 0.024 14.3 0.4 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5336) Sulfotransfer_4 PF17784.1 ETO10164.1 - 2.2e-54 184.5 0.2 2.6e-54 184.3 0.2 1.0 1 0 0 1 1 1 1 Sulfotransferase domain ETRAMP PF09716.10 ETO10164.1 - 0.018 15.1 0.0 0.018 15.1 0.0 2.0 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) APC1_C PF18122.1 ETO10164.1 - 0.12 12.3 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain Sec62 PF03839.16 ETO10165.1 - 2 7.9 4.5 2.6 7.5 4.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PI3_PI4_kinase PF00454.27 ETO10166.1 - 7.2e-07 29.3 0.0 9.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Kinesin PF00225.23 ETO10167.1 - 5.6e-60 203.0 1.6 1.4e-58 198.4 1.6 2.3 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO10167.1 - 1.6e-20 73.5 1.0 1.8e-19 70.2 1.0 2.3 1 1 0 1 1 1 1 Microtubule binding DUF2826 PF11442.8 ETO10168.1 - 0.098 12.5 0.1 0.12 12.2 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) Drf_FH1 PF06346.12 ETO10169.1 - 0.00019 21.2 30.9 0.00019 21.2 30.9 1.6 2 0 0 2 2 2 1 Formin Homology Region 1 EF-hand_8 PF13833.6 ETO10169.1 - 0.0061 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 ETO10169.1 - 0.053 14.0 0.3 0.19 12.2 0.3 1.9 1 0 0 1 1 1 0 EF-hand domain pair Ceramidase_alk PF04734.13 ETO10169.1 - 0.065 11.9 0.5 0.13 10.9 0.5 1.3 1 0 0 1 1 1 0 Neutral/alkaline non-lysosomal ceramidase, N-terminal WD40 PF00400.32 ETO10171.1 - 8.6e-07 29.6 0.6 0.042 14.7 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10171.1 - 4.3e-05 23.7 0.0 0.069 13.5 0.0 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PRD1_DD PF11087.8 ETO10171.1 - 0.97 9.2 6.9 0.86 9.4 2.6 2.7 1 1 1 2 2 2 0 PRD1 phage membrane DNA delivery Ribosomal_S9 PF00380.19 ETO10172.1 - 6.9e-11 42.7 1.5 2.2e-10 41.1 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein S9/S16 WD40 PF00400.32 ETO10173.1 - 5.2e-09 36.6 8.9 0.0037 18.1 0.3 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Diphthami_syn_2 PF01902.17 ETO10173.1 - 0.065 12.7 0.0 0.092 12.2 0.0 1.3 1 0 0 1 1 1 0 Diphthamide synthase tRNA_int_endo PF01974.17 ETO10174.1 - 2.9e-06 27.2 0.1 3.6e-05 23.7 0.1 2.2 1 1 0 1 1 1 1 tRNA intron endonuclease, catalytic C-terminal domain Rapsyn_N PF10579.9 ETO10174.1 - 0.028 14.5 0.1 0.065 13.3 0.1 1.5 1 0 0 1 1 1 0 Rapsyn N-terminal myristoylation and linker region CxxCxxCC PF03692.15 ETO10174.1 - 2.4 8.9 7.0 0.59 10.9 1.8 2.3 3 0 0 3 3 3 0 Putative zinc- or iron-chelating domain Helicase_C PF00271.31 ETO10175.1 - 3.4e-07 30.6 0.0 2.5e-06 27.8 0.0 1.9 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Prok-RING_4 PF14447.6 ETO10176.1 - 2.6e-14 52.8 9.2 6.6e-14 51.5 9.2 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETO10176.1 - 1e-07 31.7 6.2 1e-07 31.7 6.2 1.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO10176.1 - 5.8e-07 29.4 8.3 1.6e-06 28.0 8.3 1.8 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETO10176.1 - 3e-05 23.8 7.6 7.4e-05 22.5 7.6 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO10176.1 - 4.7e-05 23.3 3.0 0.00013 21.9 3.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO10176.1 - 0.00011 22.5 8.1 0.00011 22.5 8.1 1.8 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO10176.1 - 0.00015 21.6 8.9 0.00038 20.3 8.9 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) SNF2_N PF00176.23 ETO10176.1 - 0.00041 19.2 0.5 0.014 14.1 0.1 2.1 2 0 0 2 2 2 1 SNF2 family N-terminal domain zf-rbx1 PF12678.7 ETO10176.1 - 0.0012 19.1 5.2 0.0035 17.6 5.2 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO10176.1 - 0.003 17.6 1.6 0.0055 16.7 1.6 1.4 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ETO10176.1 - 0.0074 16.4 7.3 0.018 15.2 7.3 1.7 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-UDP PF14569.6 ETO10176.1 - 0.016 15.3 0.6 0.04 14.0 0.6 1.7 1 0 0 1 1 1 0 Zinc-binding RING-finger zf-RING_4 PF14570.6 ETO10176.1 - 0.027 14.2 4.3 0.07 12.9 4.3 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ETO10176.1 - 0.037 13.9 3.1 0.09 12.7 3.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein TF_Zn_Ribbon PF08271.12 ETO10176.1 - 0.044 13.3 0.5 0.044 13.3 0.5 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding FYDLN_acid PF09538.10 ETO10176.1 - 0.072 13.8 7.0 0.17 12.6 7.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) AAA_11 PF13086.6 ETO10176.1 - 0.15 11.8 6.0 0.18 11.5 6.0 1.3 1 0 0 1 1 1 0 AAA domain Zn_Tnp_IS91 PF14319.6 ETO10176.1 - 0.19 11.8 6.4 0.37 10.9 2.9 2.6 1 1 1 2 2 2 0 Transposase zinc-binding domain CDC45 PF02724.14 ETO10176.1 - 0.41 8.9 10.3 0.55 8.4 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Abi_2 PF07751.11 ETO10176.1 - 0.49 10.6 5.0 0.75 10.0 0.1 2.2 2 0 0 2 2 2 0 Abi-like protein Zn_ribbon_17 PF17120.5 ETO10176.1 - 0.77 9.4 6.1 2.7 7.7 6.2 1.9 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type Presenilin PF01080.17 ETO10176.1 - 1.1 7.9 5.9 1.3 7.7 5.9 1.2 1 0 0 1 1 1 0 Presenilin AIF_C PF14721.6 ETO10176.1 - 1.4 9.3 9.6 28 5.1 9.6 2.2 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DZR PF12773.7 ETO10176.1 - 1.5 8.9 6.8 10 6.3 1.9 2.5 1 1 1 2 2 2 0 Double zinc ribbon GET2 PF08690.10 ETO10176.1 - 1.9 8.1 7.1 3 7.5 6.0 1.8 2 0 0 2 2 2 0 GET complex subunit GET2 ALMT PF11744.8 ETO10176.1 - 4.6 6.0 5.8 5.2 5.8 5.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF913 PF06025.12 ETO10176.1 - 4.7 6.1 9.6 28 3.5 9.5 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 ETO10176.1 - 5.9 6.6 6.8 2.6 7.7 4.7 1.5 2 0 0 2 2 1 0 Connexin MDM10 PF12519.8 ETO10176.1 - 7.6 5.3 8.2 11 4.8 8.2 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 YqfQ PF14181.6 ETO10176.1 - 8.5 6.5 9.4 17 5.6 9.4 1.5 1 0 0 1 1 1 0 YqfQ-like protein SNF2_N PF00176.23 ETO10177.1 - 6.4e-62 209.3 0.0 7.4e-62 209.1 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO10177.1 - 0.00054 20.0 0.0 0.0015 18.5 0.0 1.6 1 1 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO10177.1 - 0.0032 17.3 0.0 0.0053 16.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_34 PF13872.6 ETO10177.1 - 0.0058 15.6 0.1 0.021 13.7 0.1 1.7 1 1 0 1 1 1 1 P-loop containing NTP hydrolase pore-1 Zip PF02535.22 ETO10178.1 - 6.7 5.8 5.5 9.8 5.3 5.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.8 ETO10179.1 - 0.6 10.2 2.8 0.82 9.7 2.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF2070 PF09843.9 ETO10181.1 - 2.2 6.5 12.8 2.8 6.1 12.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4227 PF14004.6 ETO10181.1 - 5.6 7.0 6.0 4.7 7.3 1.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4227) ubiquitin PF00240.23 ETO10182.1 - 0.0078 15.9 0.1 0.0078 15.9 0.1 2.2 2 0 0 2 2 2 1 Ubiquitin family MLANA PF14991.6 ETO10182.1 - 0.15 12.4 0.7 0.4 11.0 0.2 2.1 2 0 0 2 2 2 0 Protein melan-A TMEM190 PF15431.6 ETO10182.1 - 2.1 8.5 4.0 2.6 8.2 0.1 2.8 3 0 0 3 3 3 0 Transmembrane protein 190 DUF3011 PF11218.8 ETO10183.1 - 0.029 14.4 0.3 0.068 13.2 0.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3011) DUF3866 PF12982.7 ETO10183.1 - 0.042 13.0 0.2 0.055 12.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3866) DUF4174 PF13778.6 ETO10183.1 - 0.046 14.2 0.1 0.11 12.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) UPF0004 PF00919.20 ETO10183.1 - 0.055 13.5 0.0 0.16 12.0 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein family UPF0004 DnaJ PF00226.31 ETO10184.1 - 1.1e-20 73.5 4.4 1.1e-20 73.5 4.4 1.6 2 0 0 2 2 2 1 DnaJ domain zf-CSL PF05207.13 ETO10184.1 - 1.4e-06 27.9 3.0 3.6e-06 26.6 3.0 1.7 1 0 0 1 1 1 1 CSL zinc finger Cathelicidins PF00666.17 ETO10184.1 - 0.12 12.7 3.4 0.12 12.7 0.6 2.1 1 1 1 2 2 2 0 Cathelicidin RabGAP-TBC PF00566.18 ETO10185.1 - 1.7e-34 119.3 1.6 2.4e-31 109.1 0.2 3.1 2 1 1 3 3 3 2 Rab-GTPase-TBC domain Zip PF02535.22 ETO10185.1 - 0.7 9.0 3.2 0.9 8.7 3.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter H_PPase PF03030.16 ETO10186.1 - 3.8e-128 429.0 8.0 4.3e-128 428.8 8.0 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase TatD_DNase PF01026.21 ETO10187.1 - 1.8e-23 83.2 0.0 8.6e-23 81.0 0.0 1.9 2 0 0 2 2 2 1 TatD related DNase Glucos_trans_II PF14264.6 ETO10187.1 - 0.77 9.0 4.4 0.15 11.4 0.7 1.6 2 0 0 2 2 2 0 Glucosyl transferase GtrII UCH PF00443.29 ETO10188.1 - 3.1e-16 59.6 0.6 4.8e-16 59.0 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO10188.1 - 1.1e-10 41.6 1.8 1.5e-10 41.2 1.8 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CoA_transf_3 PF02515.17 ETO10189.1 - 7.7e-78 262.2 0.0 1.2e-77 261.5 0.0 1.3 1 1 0 1 1 1 1 CoA-transferase family III TFIIA PF03153.13 ETO10192.1 - 0.00047 20.3 39.6 0.00052 20.1 39.6 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 ETO10192.1 - 0.55 8.7 24.0 0.62 8.6 24.0 1.1 1 0 0 1 1 1 0 Macoilin family Caldesmon PF02029.15 ETO10192.1 - 5.5 5.6 38.1 6.3 5.4 38.1 1.1 1 0 0 1 1 1 0 Caldesmon Methyltransf_32 PF13679.6 ETO10193.1 - 4.3e-06 26.8 3.4 6.1e-05 23.1 3.4 2.4 1 1 0 1 1 1 1 Methyltransferase domain zf-RING_5 PF14634.6 ETO10194.1 - 0.031 14.2 1.7 0.05 13.6 1.7 1.3 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_14 PF17978.1 ETO10194.1 - 0.057 13.9 0.9 0.14 12.6 0.8 1.6 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 ETO10194.1 - 0.11 12.5 1.3 0.22 11.6 1.3 1.5 1 0 0 1 1 1 0 RING-type zinc-finger Cwf_Cwc_15 PF04889.12 ETO10194.1 - 0.19 11.5 9.1 0.26 11.0 9.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CENP-B_dimeris PF09026.10 ETO10194.1 - 1.1 9.7 12.4 1.9 8.9 12.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ETO10194.1 - 1.2 8.2 11.1 1.6 7.8 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO10194.1 - 7 4.6 10.3 8.6 4.3 10.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Myotub-related PF06602.14 ETO10195.1 - 7.6e-104 347.4 5.0 8.6e-90 301.2 0.1 2.0 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain DSPc PF00782.20 ETO10195.1 - 5.1e-05 23.1 0.3 0.0001 22.1 0.3 1.5 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO10195.1 - 9.7e-05 22.0 0.0 0.0002 21.0 0.0 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ETO10195.1 - 0.00072 19.6 0.0 0.001 19.1 0.0 1.2 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ETO10195.1 - 0.0021 17.7 0.1 0.0041 16.7 0.1 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family ArfGap PF01412.18 ETO10196.1 - 0.75 9.9 6.1 0.083 13.0 0.8 2.2 2 1 0 2 2 2 0 Putative GTPase activating protein for Arf PARG_cat PF05028.14 ETO10197.1 - 1.1e-68 232.1 9.5 1.2e-41 143.1 0.3 3.1 2 1 0 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) Menin PF05053.13 ETO10197.1 - 0.12 10.8 2.1 0.17 10.2 2.1 1.2 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO10197.1 - 1.2 9.7 10.8 2.4 8.8 10.8 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DUF1829 PF08862.10 ETO10198.1 - 0.35 11.4 3.7 0.5 10.9 0.9 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF1829 Syndecan PF01034.20 ETO10200.1 - 7.1 6.6 6.3 12 5.9 0.1 2.8 3 0 0 3 3 3 0 Syndecan domain DUF2853 PF11015.8 ETO10201.1 - 0.002 18.8 1.1 0.0047 17.6 1.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF2853) HTH_psq PF05225.16 ETO10201.1 - 0.19 11.5 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 helix-turn-helix, Psq domain TIR_3 PF18567.1 ETO10201.1 - 0.25 11.4 2.6 10 6.1 0.1 2.7 3 0 0 3 3 3 0 Toll/interleukin-1 receptor domain DUF3959 PF13105.6 ETO10201.1 - 1.7 8.1 6.3 3.8 7.0 0.5 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3959) DUF2400 PF09674.10 ETO10201.1 - 2.1 8.3 7.8 0.12 12.4 2.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) DUF4407 PF14362.6 ETO10201.1 - 4.7 6.5 6.6 0.2 11.0 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Cyt-b5 PF00173.28 ETO10202.1 - 1.6e-14 53.8 0.1 3.8e-14 52.6 0.1 1.7 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain ABC_membrane PF00664.23 ETO10203.1 - 2.3e-44 152.1 7.7 2.9e-44 151.8 7.7 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region SUIM_assoc PF16619.5 ETO10205.1 - 0.0011 19.0 0.6 0.0011 19.0 0.6 2.8 3 0 0 3 3 3 1 Unstructured region C-term to UIM in Ataxin3 RNA_pol_Rpc4 PF05132.14 ETO10206.1 - 0.026 15.0 1.9 0.026 15.0 1.9 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 ETO10206.1 - 2.3 6.2 23.3 0.22 9.6 18.6 1.6 1 1 1 2 2 2 0 DNA polymerase phi CSG2 PF16965.5 ETO10206.1 - 4.8 6.0 8.5 4.8 6.0 0.2 2.3 2 0 0 2 2 2 0 Ceramide synthase regulator TPR_12 PF13424.6 ETO10208.1 - 5.8e-40 135.5 2.1 9.5e-14 51.5 0.0 3.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10208.1 - 4.8e-19 67.6 0.0 5.4e-08 32.5 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10208.1 - 4.2e-17 61.2 14.9 1.8e-09 37.0 0.3 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10208.1 - 1e-14 53.4 0.3 3.7e-05 23.5 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10208.1 - 1.6e-11 43.4 9.6 4.7e-05 23.2 0.0 3.9 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10208.1 - 1.8e-09 37.0 16.9 5.9e-07 29.2 0.2 4.5 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO10208.1 - 4.1e-08 33.1 0.7 0.0026 18.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO10208.1 - 0.0032 17.3 4.1 1.4 8.7 0.0 3.0 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETO10208.1 - 0.0036 17.9 0.0 3.7 8.3 0.0 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO10208.1 - 0.0045 17.5 0.1 13 6.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO10208.1 - 0.0067 15.8 0.0 0.0089 15.4 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region TPR_11 PF13414.6 ETO10208.1 - 0.036 13.7 9.6 0.28 10.9 0.1 3.5 3 1 1 4 4 4 0 TPR repeat TPR_21 PF09976.9 ETO10208.1 - 0.059 13.1 0.1 0.15 11.7 0.0 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain YecM PF06185.12 ETO10208.1 - 0.059 13.0 0.1 0.47 10.1 0.0 2.1 2 0 0 2 2 2 0 YecM protein SHNi-TPR PF10516.9 ETO10208.1 - 0.075 12.5 0.1 29 4.2 0.0 3.3 3 1 0 3 3 3 0 SHNi-TPR PPR PF01535.20 ETO10208.1 - 0.091 13.0 1.1 0.31 11.4 0.1 2.4 3 0 0 3 3 2 0 PPR repeat TFIIE_alpha PF02002.17 ETO10208.1 - 0.92 9.4 5.3 1.3 8.9 0.2 2.3 2 0 0 2 2 2 0 TFIIE alpha subunit TPR_3 PF07720.12 ETO10208.1 - 1.1 9.3 8.8 0.83 9.7 2.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat SET PF00856.28 ETO10209.1 - 9.4e-22 78.2 0.6 3.5e-21 76.3 0.6 1.8 1 1 0 1 1 1 1 SET domain EVI2A PF05399.11 ETO10211.1 - 0.011 15.4 0.5 0.027 14.1 0.5 1.7 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) TMEM154 PF15102.6 ETO10211.1 - 0.11 12.4 0.1 0.11 12.4 0.1 1.7 2 0 0 2 2 2 0 TMEM154 protein family AIG2_2 PF13772.6 ETO10213.1 - 1.6e-06 28.4 0.0 3.7e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 AIG2-like family GGACT PF06094.12 ETO10213.1 - 0.0024 18.5 0.2 0.0042 17.7 0.2 1.3 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AbiEi_4 PF13338.6 ETO10213.1 - 0.013 15.6 0.0 0.025 14.7 0.0 1.5 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin G-alpha PF00503.20 ETO10214.1 - 9.8e-73 245.3 19.4 2.8e-60 204.3 11.4 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO10214.1 - 3.9e-09 36.2 2.6 2.6e-06 27.0 0.0 3.0 3 0 0 3 3 3 2 ADP-ribosylation factor family Roc PF08477.13 ETO10214.1 - 0.0044 17.2 0.3 5.2 7.3 0.0 2.8 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase UCH PF00443.29 ETO10214.1 - 0.01 15.3 0.0 0.05 13.1 0.0 2.2 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase OAD_gamma PF04277.13 ETO10214.1 - 0.22 12.2 1.3 0.39 11.4 1.3 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF4710 PF15828.5 ETO10214.1 - 0.34 11.0 11.0 0.4 10.8 8.5 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) SR-25 PF10500.9 ETO10214.1 - 1.5 8.4 13.5 2.7 7.5 13.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 ETO10214.1 - 2 8.4 8.0 3.7 7.6 8.0 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SAS-6_N PF16531.5 ETO10215.1 - 0.12 13.0 3.4 0.093 13.3 0.9 2.1 2 0 0 2 2 2 0 Centriolar protein SAS N-terminal SNCAIP_SNCA_bd PF16700.5 ETO10215.1 - 0.37 10.5 6.3 1.1 9.0 0.3 3.0 3 0 0 3 3 3 0 Synphilin-1 alpha-Synuclein-binding domain RAB3GAP2_N PF14655.6 ETO10216.1 - 1.4e-26 93.7 0.1 1.6e-19 70.5 0.0 2.2 2 0 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus SPRY PF00622.28 ETO10216.1 - 5.1e-07 29.8 0.1 1.6e-06 28.2 0.1 1.8 1 0 0 1 1 1 1 SPRY domain DEP PF00610.21 ETO10217.1 - 5e-34 116.2 1.4 1.1e-17 63.8 0.3 2.7 2 1 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF2188 PF09954.9 ETO10217.1 - 0.067 13.3 1.1 5.1 7.3 0.2 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2188) Exo_endo_phos PF03372.23 ETO10218.1 - 4.9e-17 62.2 0.0 1.3e-16 60.9 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ETO10218.1 - 0.00029 20.7 0.3 0.47 10.3 0.0 3.0 2 1 0 2 2 2 2 Endonuclease-reverse transcriptase RecQ_Zn_bind PF16124.5 ETO10218.1 - 0.12 13.1 0.9 0.54 11.0 0.2 2.4 2 0 0 2 2 2 0 RecQ zinc-binding PDCD9 PF07147.12 ETO10219.1 - 0.013 14.8 0.0 0.016 14.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S30 (PDCD9) PCM1_C PF15717.5 ETO10219.1 - 0.062 12.0 0.0 0.076 11.7 0.0 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus 2_5_RNA_ligase2 PF13563.6 ETO10220.1 - 1.5e-30 106.1 0.4 2.5e-30 105.4 0.4 1.3 1 0 0 1 1 1 1 2'-5' RNA ligase superfamily DUF488 PF04343.13 ETO10220.1 - 3.7e-13 50.1 1.1 8e-12 45.8 0.2 2.8 2 1 0 2 2 2 1 Protein of unknown function, DUF488 zf-Di19 PF05605.12 ETO10220.1 - 0.11 12.8 1.3 9.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Podoplanin PF05808.11 ETO10221.1 - 0.011 15.9 0.1 0.034 14.2 0.1 1.8 1 0 0 1 1 1 0 Podoplanin START PF01852.19 ETO10222.1 - 1.8e-11 43.9 0.6 4.1e-07 29.6 0.0 3.0 3 1 0 3 3 3 2 START domain Mo-nitro_C PF06967.11 ETO10222.1 - 0.12 12.4 0.1 0.27 11.2 0.1 1.6 1 0 0 1 1 1 0 Mo-dependent nitrogenase C-terminus Amidohydro_2 PF04909.14 ETO10223.1 - 2.7e-28 99.6 0.0 3.4e-28 99.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase COPIIcoated_ERV PF07970.12 ETO10224.1 - 1e-48 166.1 0.2 1.4e-48 165.7 0.2 1.1 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ERGIC_N PF13850.6 ETO10225.1 - 9.9e-19 67.5 0.4 1.4e-18 67.1 0.4 1.2 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) DUF1422 PF07226.11 ETO10225.1 - 0.02 14.9 0.6 0.025 14.6 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1422) UPA PF17217.3 ETO10226.1 - 0.041 13.8 0.1 0.046 13.6 0.1 1.0 1 0 0 1 1 1 0 UPA domain RRM_1 PF00076.22 ETO10227.1 - 0.002 17.9 0.1 0.13 12.1 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO10228.1 - 1.2e-09 37.8 0.0 0.0081 16.0 0.0 4.8 6 0 0 6 6 6 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2028 PF09667.10 ETO10228.1 - 0.056 13.4 0.2 0.13 12.2 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2028) SDA1 PF05285.12 ETO10228.1 - 7.2 5.9 17.3 11 5.3 17.3 1.2 1 0 0 1 1 1 0 SDA1 PH PF00169.29 ETO10229.1 - 2.4e-07 31.2 1.8 5.3e-07 30.1 1.8 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO10229.1 - 0.0016 18.8 1.2 0.0016 18.8 1.2 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain DUF334 PF03904.13 ETO10229.1 - 0.58 9.7 6.7 1 8.8 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF334) CH PF00307.31 ETO10230.1 - 1.1e-22 80.2 8.9 3.4e-09 36.9 0.2 4.7 4 2 0 4 4 4 3 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO10230.1 - 2.8e-06 27.1 2.0 0.062 13.1 0.0 3.7 3 0 0 3 3 3 2 CAMSAP CH domain Melibiase_2 PF16499.5 ETO10231.1 - 2.1e-68 230.6 5.1 5e-46 157.2 1.1 2.3 2 0 0 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 ETO10231.1 - 1.6e-17 63.3 0.2 3.6e-17 62.2 0.2 1.6 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ETO10231.1 - 0.00023 20.2 0.0 0.00067 18.7 0.0 1.7 2 0 0 2 2 2 1 Melibiase Melibiase_2_C PF17450.2 ETO10231.1 - 0.0013 19.0 0.0 0.0022 18.2 0.0 1.4 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Amidohydro_2 PF04909.14 ETO10232.1 - 5.7e-22 78.8 0.0 7.1e-22 78.5 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Sigma54_activ_2 PF14532.6 ETO10233.1 - 0.0017 18.5 0.0 0.0033 17.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Sulfotransfer_3 PF13469.6 ETO10233.1 - 0.008 16.6 0.7 0.015 15.7 0.2 1.7 2 0 0 2 2 2 1 Sulfotransferase family Nmad3 PF18754.1 ETO10235.1 - 1.1 8.8 6.0 3.8 7.0 6.0 2.0 1 0 0 1 1 1 0 Nucleotide modification associated domain 3 eIF-3c_N PF05470.12 ETO10236.1 - 0.031 12.6 0.6 0.038 12.3 0.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Radial_spoke PF04712.12 ETO10236.1 - 0.042 12.8 0.6 0.054 12.4 0.6 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein EVI2A PF05399.11 ETO10237.1 - 2.4 7.7 10.8 2.9 7.4 10.8 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) BTB PF00651.31 ETO10238.1 - 0.0024 18.1 0.5 0.0056 16.9 0.1 1.8 2 0 0 2 2 2 1 BTB/POZ domain NUMOD4 PF07463.11 ETO10238.1 - 0.072 13.3 0.0 0.2 11.9 0.0 1.8 2 0 0 2 2 2 0 NUMOD4 motif Connexin PF00029.19 ETO10239.1 - 0.13 12.0 0.9 0.25 11.1 0.4 1.6 2 0 0 2 2 2 0 Connexin Kei1 PF08552.11 ETO10239.1 - 0.86 9.4 2.6 0.79 9.6 1.0 1.6 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 Ferlin_C PF16165.5 ETO10239.1 - 3.9 7.4 7.6 7 6.6 2.7 2.3 2 0 0 2 2 2 0 Ferlin C-terminus Sec62 PF03839.16 ETO10239.1 - 5.5 6.4 8.6 6.7 6.2 4.6 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Peptidase_S49_N PF08496.10 ETO10239.1 - 9.7 6.2 7.8 10 6.2 5.1 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Docking PF08990.11 ETO10240.1 - 0.12 12.0 1.7 0.31 10.7 1.7 1.7 1 0 0 1 1 1 0 Erythronolide synthase docking ACP_PD PF04336.12 ETO10240.1 - 0.53 10.7 8.6 0.15 12.4 1.6 3.2 3 0 0 3 3 3 0 Acyl carrier protein phosphodiesterase CENP-B_dimeris PF09026.10 ETO10241.1 - 1.1 9.7 23.5 0.092 13.2 11.6 3.4 3 0 0 3 3 3 0 Centromere protein B dimerisation domain DUF3854 PF12965.7 ETO10242.1 - 0.075 13.0 2.9 0.095 12.7 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3854) DUF1688 PF07958.11 ETO10243.1 - 1.1e-135 452.7 0.0 9.8e-118 393.5 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1688) GTP_cyclohydro2 PF00925.20 ETO10243.1 - 3.8e-17 62.4 0.0 6.7e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 GTP cyclohydrolase II Q_salvage PF10343.9 ETO10243.1 - 0.00032 20.4 0.0 0.0087 15.7 0.0 2.2 2 0 0 2 2 2 1 Potential Queuosine, Q, salvage protein family GTP_CH_N PF12471.8 ETO10243.1 - 0.0012 18.6 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal MAD PF05557.13 ETO10244.1 - 0.00099 17.6 34.0 0.00099 17.6 34.0 2.2 2 0 0 2 2 2 1 Mitotic checkpoint protein Spc7 PF08317.11 ETO10244.1 - 0.06 12.2 49.1 0.084 11.7 22.3 3.2 2 1 1 3 3 3 0 Spc7 kinetochore protein HMMR_N PF15905.5 ETO10244.1 - 0.3 10.5 52.6 0.91 8.9 17.6 3.3 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF1664 PF07889.12 ETO10244.1 - 2.7 8.0 35.3 0.66 10.0 3.8 4.4 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) DUF812 PF05667.11 ETO10244.1 - 4.4 6.1 45.5 2.2 7.0 3.5 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF812) HAUS-augmin3 PF14932.6 ETO10244.1 - 4.5 6.8 41.1 8.6 5.9 31.0 3.0 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 Sybindin PF04099.12 ETO10246.1 - 0.039 13.9 0.0 0.047 13.6 0.0 1.2 1 0 0 1 1 1 0 Sybindin-like family GRIM-19 PF06212.12 ETO10246.1 - 0.06 13.3 0.0 0.078 12.9 0.0 1.1 1 0 0 1 1 1 0 GRIM-19 protein DUF3824 PF12868.7 ETO10249.1 - 0.021 15.5 2.2 0.027 15.1 2.2 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Herpes_UL37_1 PF03970.13 ETO10249.1 - 0.14 11.3 0.0 0.2 10.9 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL37 tegument protein Pkinase_Tyr PF07714.17 ETO10251.1 - 4.6e-10 39.2 0.1 9.3e-10 38.2 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO10251.1 - 2.7e-06 26.9 0.0 1.1e-05 24.9 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain PA26 PF04636.13 ETO10251.1 - 0.15 10.9 3.4 0.2 10.5 3.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pkinase PF00069.25 ETO10253.1 - 1.2e-12 47.8 0.0 2e-12 47.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10253.1 - 5.2e-12 45.6 0.0 9e-12 44.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Orf78 PF06024.12 ETO10253.1 - 0.11 12.8 2.1 10 6.5 0.2 2.5 2 0 0 2 2 2 0 Orf78 (ac78) WD40 PF00400.32 ETO10255.1 - 8.5e-61 200.5 26.5 4.4e-09 36.8 0.5 8.3 9 0 0 9 9 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10255.1 - 7.3e-23 80.7 7.5 0.00033 20.9 0.1 7.1 3 1 5 8 8 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10255.1 - 4e-16 58.9 2.9 0.015 14.3 0.0 7.0 2 1 5 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO10255.1 - 1.1e-06 27.6 2.6 0.044 12.4 0.0 4.6 1 1 3 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO10255.1 - 3.3e-05 22.6 0.9 0.095 11.2 0.1 3.6 2 1 2 4 4 4 2 Cytochrome D1 heme domain Kelch_6 PF13964.6 ETO10255.1 - 0.00011 22.3 6.3 0.33 11.3 0.0 4.4 3 1 1 4 4 4 2 Kelch motif DUF5570 PF17731.1 ETO10255.1 - 0.00024 21.2 0.6 7.1 6.7 0.0 4.2 2 1 2 4 4 4 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO10255.1 - 0.00033 20.1 2.6 0.057 12.7 0.0 4.2 2 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Kelch_4 PF13418.6 ETO10255.1 - 0.00043 20.2 0.1 0.0031 17.5 0.0 2.5 3 0 0 3 3 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO10255.1 - 0.00051 19.6 0.1 3.7 7.2 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO10255.1 - 0.00089 19.2 0.7 1.5 8.9 0.0 4.3 4 0 0 4 4 4 1 Kelch motif N_Asn_amidohyd PF14736.6 ETO10255.1 - 0.012 14.8 0.2 2.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Proteasome_A_N PF10584.9 ETO10255.1 - 0.02 14.6 0.1 37 4.1 0.0 3.6 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 ETO10255.1 - 0.054 12.4 2.3 3 6.7 0.1 3.6 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 ETO10255.1 - 0.1 12.2 0.1 0.31 10.6 0.1 1.7 1 1 0 1 1 1 0 PQQ-like domain Iron_permease PF04120.12 ETO10255.1 - 0.16 11.7 2.2 0.63 9.8 2.2 2.0 1 0 0 1 1 1 0 Low affinity iron permease ETF PF01012.21 ETO10256.1 - 9.9e-06 25.6 0.0 1.2e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF PF01012.21 ETO10257.1 - 9.5e-26 90.8 0.1 1.9e-25 89.8 0.1 1.4 2 0 0 2 2 2 1 Electron transfer flavoprotein domain Acetyltransf_6 PF13480.7 ETO10258.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zinc_ribbon_15 PF17032.5 ETO10259.1 - 1.6 9.5 14.8 3.1 8.6 2.6 3.1 1 1 2 3 3 3 0 zinc-ribbon family TPR_19 PF14559.6 ETO10260.1 - 1.1e-07 32.2 18.1 0.74 10.4 0.0 8.3 7 1 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO10260.1 - 0.0061 17.3 8.7 17 6.5 0.0 7.8 9 1 0 9 9 9 1 Tetratricopeptide repeat RtcR PF06956.11 ETO10260.1 - 0.0064 15.9 1.4 0.082 12.3 0.1 2.5 2 0 0 2 2 2 1 Regulator of RNA terminal phosphate cyclase ANAPC3 PF12895.7 ETO10260.1 - 0.01 16.1 43.0 0.83 9.9 2.3 10.3 6 3 3 10 10 10 0 Anaphase-promoting complex, cyclosome, subunit 3 YqaH PF17448.2 ETO10260.1 - 0.054 13.8 0.2 1.9 8.9 0.0 3.6 3 0 0 3 3 3 0 Uncharacterized YqaH-like SecA_PP_bind PF01043.20 ETO10260.1 - 0.088 13.5 0.2 0.088 13.5 0.2 4.6 3 2 1 4 4 4 0 SecA preprotein cross-linking domain TPR_12 PF13424.6 ETO10260.1 - 1.5 9.1 22.3 1.3 9.4 0.0 8.5 7 1 1 8 8 8 0 Tetratricopeptide repeat Metallophos PF00149.28 ETO10261.1 - 2.7e-27 96.6 0.0 3.2e-27 96.4 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO10261.1 - 0.00085 19.7 0.4 0.0018 18.7 0.4 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos_2 PF12850.7 ETO10261.1 - 0.0064 16.7 0.0 0.0096 16.1 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain LRRNT_2 PF08263.12 ETO10262.1 - 0.00051 20.3 0.9 0.0014 18.9 0.9 1.8 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 ETO10262.1 - 0.21 11.4 7.2 0.72 9.7 3.0 2.9 2 1 0 2 2 2 0 Leucine rich repeat JmjC PF02373.22 ETO10264.1 - 3.4e-06 27.5 0.9 7.7e-06 26.3 0.0 2.0 2 0 0 2 2 2 1 JmjC domain, hydroxylase DUF1788 PF08747.11 ETO10264.1 - 0.1 12.6 1.8 7.3 6.6 0.1 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF1788) Corona_7 PF02398.16 ETO10264.1 - 0.31 11.6 2.2 60 4.3 0.0 2.7 2 1 0 2 2 2 0 Coronavirus protein 7 DNA_pol_P_Exo PF18049.1 ETO10266.1 - 0.06 12.7 0.4 0.097 12.1 0.4 1.2 1 0 0 1 1 1 0 DNA polymerase nu pseudo-exo ETRAMP PF09716.10 ETO10267.1 - 1.7 8.8 8.4 0.52 10.4 4.7 1.9 1 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) COBRA1 PF06209.13 ETO10268.1 - 0.0036 16.2 0.2 0.006 15.5 0.2 1.3 1 0 0 1 1 1 1 Cofactor of BRCA1 (COBRA1) HECT PF00632.25 ETO10269.1 - 6.4e-57 193.4 0.1 1e-56 192.7 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.6 ETO10269.1 - 5.6e-14 52.6 0.0 1.4e-13 51.2 0.0 1.7 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 ETO10269.1 - 0.014 16.0 0.0 0.05 14.2 0.0 1.9 1 0 0 1 1 1 0 Laminin G domain IF4E PF01652.18 ETO10270.1 - 8.3e-39 132.9 2.7 1.9e-38 131.8 2.7 1.6 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Hormone_recep PF00104.30 ETO10271.1 - 0.069 12.7 0.5 0.3 10.6 0.0 1.9 2 0 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor RhoGAP PF00620.27 ETO10272.1 - 1.3e-08 34.8 0.2 2.8e-06 27.2 0.2 3.1 1 1 0 1 1 1 1 RhoGAP domain LRR_6 PF13516.6 ETO10272.1 - 1.7e-05 24.5 12.0 0.08 13.0 0.7 5.2 5 0 0 5 5 5 3 Leucine Rich repeat RasGEF_N PF00618.20 ETO10272.1 - 0.63 10.3 9.5 0.37 11.1 0.2 3.3 3 0 0 3 3 3 0 RasGEF N-terminal motif LAP1C PF05609.12 ETO10272.1 - 8.2 5.4 25.8 1.5 7.8 13.6 2.4 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) RabGAP-TBC PF00566.18 ETO10273.1 - 0.0067 16.1 0.2 0.0067 16.1 0.2 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Orf78 PF06024.12 ETO10273.1 - 0.019 15.2 0.3 0.019 15.2 0.3 2.8 2 1 0 2 2 2 0 Orf78 (ac78) DUF4551 PF15087.6 ETO10273.1 - 3.3 6.4 7.3 4.3 6.1 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RabGAP-TBC PF00566.18 ETO10274.1 - 7.7e-21 74.7 3.7 1.1e-20 74.2 3.7 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain TMEM238 PF15125.6 ETO10274.1 - 0.039 14.2 2.2 0.22 11.7 0.1 2.9 3 0 0 3 3 3 0 TMEM238 protein family DUF2625 PF10946.8 ETO10274.1 - 0.12 11.5 0.1 0.2 10.7 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 HhH-GPD PF00730.25 ETO10276.1 - 3.8e-05 24.1 0.0 0.00011 22.7 0.0 1.8 1 0 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein Jak1_Phl PF17887.1 ETO10276.1 - 2.1 8.3 13.9 0.08 12.9 5.5 2.2 1 1 1 2 2 2 0 Jak1 pleckstrin homology-like domain Aldedh PF00171.22 ETO10277.1 - 1.4e-142 475.5 0.1 1.8e-141 471.8 0.1 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Vps4_C PF09336.10 ETO10278.1 - 0.13 12.3 0.0 0.45 10.6 0.0 2.0 1 0 0 1 1 1 0 Vps4 C terminal oligomerisation domain DUF1882 PF08966.11 ETO10279.1 - 0.021 15.1 1.0 0.052 13.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1882) DOMON PF03351.17 ETO10280.1 - 9.1e-06 25.9 1.0 1.9e-05 24.9 0.8 1.6 1 1 1 2 2 2 1 DOMON domain Phage_T4_gp36 PF03903.13 ETO10280.1 - 0.26 11.2 2.7 0.81 9.6 1.8 2.2 1 1 1 2 2 2 0 Phage T4 tail fibre CSD PF00313.22 ETO10281.1 - 0.00044 20.0 0.1 0.87 9.5 0.0 2.4 2 0 0 2 2 2 2 'Cold-shock' DNA-binding domain TnsD PF15978.5 ETO10281.1 - 0.022 13.7 0.2 0.028 13.4 0.2 1.1 1 0 0 1 1 1 0 Tn7-like transposition protein D Pes-10 PF07149.11 ETO10282.1 - 0.0061 15.7 3.8 0.007 15.5 3.8 1.2 1 0 0 1 1 1 1 Pes-10 Serinc PF03348.15 ETO10282.1 - 0.02 13.8 0.3 0.03 13.3 0.3 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CobT PF06213.12 ETO10282.1 - 0.039 13.3 11.2 0.054 12.9 11.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nop14 PF04147.12 ETO10282.1 - 0.047 11.9 19.0 0.052 11.8 19.0 1.1 1 0 0 1 1 1 0 Nop14-like family Exo_endo_phos PF03372.23 ETO10282.1 - 0.059 12.9 0.0 0.099 12.1 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Dynamin_N PF00350.23 ETO10282.1 - 0.061 13.4 0.3 0.12 12.4 0.3 1.6 1 0 0 1 1 1 0 Dynamin family BUD22 PF09073.10 ETO10282.1 - 0.097 12.0 20.9 0.12 11.6 20.9 1.2 1 0 0 1 1 1 0 BUD22 TFIIA PF03153.13 ETO10282.1 - 0.5 10.3 12.7 0.64 9.9 12.7 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4637 PF15470.6 ETO10282.1 - 0.55 9.9 13.1 1.1 9.0 13.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CNDH2_C PF16858.5 ETO10282.1 - 2.6 7.8 16.5 3.3 7.5 16.5 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term STAC2_u1 PF16664.5 ETO10282.1 - 3.2 8.2 13.4 0.58 10.6 9.7 1.7 2 1 0 2 2 2 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 RR_TM4-6 PF06459.12 ETO10282.1 - 6.3 6.5 20.2 10 5.8 20.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3819 PF12842.7 ETO10283.1 - 0.0045 16.9 1.3 4 7.4 2.0 2.7 2 1 0 2 2 2 2 Domain of unknown function (DUF3819) Chordopox_A33R PF05966.12 ETO10283.1 - 0.077 12.3 0.2 0.1 11.9 0.2 1.3 1 0 0 1 1 1 0 Chordopoxvirus A33R protein 5_3_exonuc_N PF02739.16 ETO10284.1 - 0.17 11.7 0.0 0.55 10.1 0.0 1.7 1 1 0 2 2 2 0 5'-3' exonuclease, N-terminal resolvase-like domain Spaetzle PF16077.5 ETO10286.1 - 0.0058 17.1 4.4 0.0061 17.1 2.2 2.2 1 1 1 2 2 2 1 Spaetzle zf-TRAF PF02176.18 ETO10287.1 - 7.9e-08 32.9 5.0 7.9e-08 32.9 5.0 2.9 2 1 1 3 3 3 1 TRAF-type zinc finger DUF1640 PF07798.11 ETO10287.1 - 0.15 12.1 3.2 0.28 11.2 3.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) GGACT PF06094.12 ETO10288.1 - 9.3e-17 61.8 0.1 1.9e-16 60.8 0.1 1.5 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 ETO10288.1 - 4.5e-06 27.0 0.9 7.6e-06 26.2 0.2 1.8 2 0 0 2 2 2 1 AIG2-like family TrbC PF04956.13 ETO10288.1 - 0.049 13.9 0.1 0.077 13.2 0.1 1.2 1 0 0 1 1 1 0 TrbC/VIRB2 family Vta1_C PF18097.1 ETO10289.1 - 1.3e-15 56.7 0.3 2e-15 56.2 0.3 1.3 1 0 0 1 1 1 1 Vta1 C-terminal domain Upf2 PF04050.14 ETO10289.1 - 0.033 14.9 0.1 0.065 14.0 0.1 1.5 1 0 0 1 1 1 0 Up-frameshift suppressor 2 Snf7 PF03357.21 ETO10289.1 - 0.047 13.3 2.0 3.3 7.3 0.3 2.2 2 0 0 2 2 2 0 Snf7 PTB PF08416.13 ETO10290.1 - 0.027 14.6 0.6 0.61 10.2 0.2 2.3 2 0 0 2 2 2 0 Phosphotyrosine-binding domain Velvet PF11754.8 ETO10290.1 - 0.047 13.6 0.8 0.087 12.8 0.8 1.4 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 ETO10290.1 - 0.2 11.1 2.9 0.34 10.3 2.9 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Myc_N PF01056.18 ETO10290.1 - 0.21 11.5 13.4 0.057 13.3 5.5 2.2 2 0 0 2 2 2 0 Myc amino-terminal region Vfa1 PF08432.10 ETO10290.1 - 0.5 10.7 9.6 0.11 12.9 3.7 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RXT2_N PF08595.11 ETO10290.1 - 0.56 10.2 10.8 3.5 7.6 0.2 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4611 PF15387.6 ETO10290.1 - 1.5 9.1 11.9 8 6.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CRA PF06589.11 ETO10290.1 - 3.9 7.6 9.0 3.8 7.6 1.0 2.5 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) RPN2_C PF18004.1 ETO10290.1 - 5.5 6.9 14.3 3.7 7.4 10.1 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain RRM_1 PF00076.22 ETO10291.1 - 1.5e-08 34.4 0.1 2.4e-06 27.3 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-UBR PF02207.20 ETO10292.1 - 6.9e-17 61.4 10.0 1.4e-16 60.3 10.0 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 ETO10292.1 - 0.27 11.4 4.3 0.93 9.7 4.3 1.9 1 0 0 1 1 1 0 B-box zinc finger GP17 PF17420.2 ETO10293.1 - 0.25 11.5 4.8 3.2 8.0 0.7 2.6 2 0 0 2 2 2 0 Superinfection exclusion gene product 17 Auxin_canalis PF05703.11 ETO10293.1 - 0.64 9.9 2.3 0.98 9.3 2.3 1.3 1 0 0 1 1 1 0 Auxin canalisation RNA_polI_A34 PF08208.11 ETO10293.1 - 4.9 7.2 13.9 8.2 6.5 13.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NIF PF03031.18 ETO10296.1 - 9e-36 123.0 1.9 9e-23 80.8 0.5 2.4 1 1 1 2 2 2 2 NLI interacting factor-like phosphatase SelB-wing_3 PF09107.11 ETO10296.1 - 0.017 14.8 0.0 0.11 12.1 0.1 2.0 2 0 0 2 2 2 0 Elongation factor SelB, winged helix XK-related PF09815.9 ETO10297.1 - 1.3e-11 44.1 16.7 2.5e-11 43.2 16.3 1.7 1 1 0 1 1 1 1 XK-related protein HlyC PF02794.16 ETO10298.1 - 0.024 14.5 0.0 0.057 13.3 0.0 1.6 1 0 0 1 1 1 0 RTX toxin acyltransferase family MutS_I PF01624.20 ETO10299.1 - 1.8e-05 24.9 0.1 4.5e-05 23.6 0.1 1.7 1 0 0 1 1 1 1 MutS domain I DUF4813 PF16072.5 ETO10299.1 - 3 7.5 5.2 4.5 6.8 5.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) Apolipoprotein PF01442.18 ETO10300.1 - 0.011 15.7 6.7 0.018 14.9 6.7 1.3 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF5446 PF17522.2 ETO10300.1 - 0.068 13.3 7.2 0.33 11.1 7.1 2.3 1 1 0 1 1 1 0 Family of unknown function (DUF5446) AbiJ_NTD3 PF18860.1 ETO10300.1 - 0.069 12.7 0.3 0.16 11.5 0.3 1.6 1 0 0 1 1 1 0 AbiJ N-terminal domain 3 MAT1 PF06391.13 ETO10300.1 - 0.081 12.7 9.4 0.14 11.9 9.4 1.4 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 TRPM_tetra PF16519.5 ETO10300.1 - 0.2 11.8 2.6 8 6.7 0.3 2.6 2 0 0 2 2 2 0 Tetramerisation domain of TRPM OmpH PF03938.14 ETO10300.1 - 0.26 11.6 10.4 0.29 11.5 9.5 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 ETO10300.1 - 0.35 10.4 3.6 0.53 9.8 3.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit COG2 PF06148.11 ETO10300.1 - 0.44 10.6 9.1 4.3 7.4 1.0 2.7 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF948 PF06103.11 ETO10300.1 - 0.54 10.5 2.7 26 5.2 0.1 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1640 PF07798.11 ETO10300.1 - 0.76 9.8 12.5 7.2 6.6 4.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) DUF148 PF02520.17 ETO10300.1 - 0.85 9.7 13.1 1.3 9.2 10.0 2.6 2 1 1 3 3 3 0 Domain of unknown function DUF148 DUF4407 PF14362.6 ETO10300.1 - 1.3 8.3 4.9 2 7.7 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) COG5 PF10392.9 ETO10300.1 - 1.6 8.9 6.5 3.8 7.7 6.5 1.7 1 0 0 1 1 1 0 Golgi transport complex subunit 5 Fungal_TACC PF12709.7 ETO10300.1 - 2.1 8.9 14.5 0.45 11.0 3.7 2.7 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF4795 PF16043.5 ETO10300.1 - 3.3 7.3 16.3 31 4.1 16.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) FlaC_arch PF05377.11 ETO10300.1 - 3.4 8.1 6.4 9 6.8 1.5 2.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) MutS_III PF05192.18 ETO10300.1 - 4.4 7.5 7.5 14 5.9 7.4 1.9 2 1 0 2 2 2 0 MutS domain III YabA PF06156.13 ETO10300.1 - 4.6 7.9 12.1 22 5.7 8.9 2.5 1 1 1 2 2 2 0 Initiation control protein YabA DUF1664 PF07889.12 ETO10300.1 - 7.1 6.7 8.9 30 4.7 5.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Kelch_6 PF13964.6 ETO10301.1 - 2.2e-06 27.7 2.9 0.0064 16.7 0.0 4.4 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO10301.1 - 0.00013 21.8 2.1 0.0053 16.7 0.0 4.0 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO10301.1 - 0.002 17.6 0.1 0.002 17.6 0.1 3.3 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO10301.1 - 0.019 15.2 0.0 0.17 12.2 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Glyco_hydro_130 PF04041.13 ETO10301.1 - 0.024 13.6 0.0 0.037 12.9 0.0 1.2 1 0 0 1 1 1 0 beta-1,4-mannooligosaccharide phosphorylase SUKH_6 PF14568.6 ETO10301.1 - 0.086 13.3 0.0 4.4 7.8 0.0 2.4 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall Menin PF05053.13 ETO10302.1 - 1.6 7.0 4.7 1.8 6.9 4.7 1.0 1 0 0 1 1 1 0 Menin CheZ PF04344.13 ETO10304.1 - 0.013 15.5 0.3 0.018 15.0 0.3 1.1 1 0 0 1 1 1 0 Chemotaxis phosphatase, CheZ CitMHS PF03600.16 ETO10304.1 - 0.36 10.0 6.9 0.16 11.2 0.1 2.2 2 0 0 2 2 2 0 Citrate transporter CENP-L PF13092.6 ETO10305.1 - 0.088 13.0 0.1 0.11 12.7 0.1 1.3 1 1 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 HTH_45 PF14947.6 ETO10305.1 - 0.091 12.8 0.1 0.15 12.1 0.1 1.4 1 0 0 1 1 1 0 Winged helix-turn-helix DUF3439 PF11921.8 ETO10306.1 - 0.13 12.2 7.8 0.51 10.3 7.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) RNA_pol_Rpc4 PF05132.14 ETO10306.1 - 8.5 6.8 11.2 0.84 10.0 4.3 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Pkinase PF00069.25 ETO10308.1 - 4.1e-35 121.4 0.0 5.7e-35 121.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10308.1 - 2.4e-12 46.7 0.0 3.6e-12 46.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO10308.1 - 0.0003 20.2 0.0 0.00056 19.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like PEPcase PF00311.17 ETO10308.1 - 0.0015 16.7 0.1 0.0021 16.2 0.1 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase DUF2492 PF10678.9 ETO10309.1 - 0.0066 16.7 0.8 0.031 14.5 0.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2492) TPR_17 PF13431.6 ETO10309.1 - 0.0092 16.3 0.2 3.9 8.1 0.2 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10309.1 - 0.097 12.5 7.0 0.5 10.3 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10309.1 - 0.27 11.5 2.7 1.8 8.9 0.1 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat PT PF04886.12 ETO10312.1 - 0.024 14.2 55.5 0.48 10.0 24.2 5.2 1 1 1 2 2 2 0 PT repeat DUF3377 PF11857.8 ETO10312.1 - 0.18 11.7 0.2 0.54 10.2 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) Orf78 PF06024.12 ETO10312.1 - 0.21 11.9 0.1 0.21 11.9 0.1 2.8 2 1 0 2 2 2 0 Orf78 (ac78) Shisa PF13908.6 ETO10312.1 - 5.6 7.2 5.6 0.38 11.0 0.1 1.8 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator PHD PF00628.29 ETO10313.1 - 1.9e-06 27.7 13.0 1.9e-06 27.7 13.0 2.4 2 0 0 2 2 2 1 PHD-finger DASH_Hsk3 PF08227.11 ETO10313.1 - 0.076 13.4 0.0 0.076 13.4 0.0 3.0 4 0 0 4 4 4 0 DASH complex subunit Hsk3 like Exo_endo_phos PF03372.23 ETO10314.1 - 0.16 11.4 0.0 0.33 10.4 0.0 1.7 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Tau95_N PF17682.1 ETO10314.1 - 0.74 10.0 5.7 0.47 10.7 2.8 2.1 2 1 0 2 2 2 0 Tau95 Triple barrel domain Connexin PF00029.19 ETO10314.1 - 4.3 7.0 9.3 44 3.7 6.9 2.1 2 0 0 2 2 2 0 Connexin DEAD PF00270.29 ETO10317.1 - 2.6e-06 27.3 0.0 6.4e-06 26.1 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 ETO10317.1 - 0.036 13.8 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 ETO10318.1 - 7.9e-09 36.0 8.6 0.86 10.6 0.9 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ATG16 PF08614.11 ETO10319.1 - 0.00022 21.5 14.6 0.00031 21.0 14.6 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Mei5 PF10376.9 ETO10319.1 - 0.0019 18.1 11.5 0.38 10.6 7.7 2.3 2 0 0 2 2 2 2 Double-strand recombination repair protein APG6_N PF17675.1 ETO10319.1 - 0.015 15.9 14.2 0.63 10.6 0.3 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region Spc29 PF17082.5 ETO10319.1 - 0.033 14.0 11.1 0.12 12.2 2.8 2.2 1 1 1 2 2 2 0 Spindle Pole Component 29 CENP-F_leu_zip PF10473.9 ETO10319.1 - 0.036 14.1 15.6 0.07 13.2 9.6 2.3 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO10319.1 - 0.064 12.1 19.3 0.25 10.2 19.3 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF641 PF04859.12 ETO10319.1 - 0.11 12.8 10.5 1.7 9.0 2.9 2.8 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) TPR_MLP1_2 PF07926.12 ETO10319.1 - 0.13 12.3 14.6 0.25 11.4 2.0 3.0 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Macoilin PF09726.9 ETO10319.1 - 0.14 10.7 7.9 0.22 10.1 7.9 1.3 1 0 0 1 1 1 0 Macoilin family DASH_Spc34 PF08657.10 ETO10319.1 - 0.16 11.8 13.1 0.33 10.7 13.1 1.6 1 1 0 1 1 1 0 DASH complex subunit Spc34 CHD5 PF04420.14 ETO10319.1 - 0.2 11.5 6.6 1 9.2 0.1 3.0 2 1 0 3 3 3 0 CHD5-like protein Exonuc_VII_L PF02601.15 ETO10319.1 - 0.35 10.4 6.5 0.46 10.0 6.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CdvA PF18822.1 ETO10319.1 - 0.4 10.5 17.8 0.36 10.6 10.5 2.9 2 1 0 2 2 2 0 CdvA-like coiled-coil domain Tup_N PF08581.10 ETO10319.1 - 0.45 10.9 14.5 0.28 11.5 8.1 2.3 2 0 0 2 2 2 0 Tup N-terminal DUF4407 PF14362.6 ETO10319.1 - 0.46 9.8 11.8 0.7 9.2 11.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF16 PF01519.16 ETO10319.1 - 0.49 10.9 20.0 0.46 11.0 5.1 3.0 1 1 1 2 2 2 0 Protein of unknown function DUF16 CENP-H PF05837.12 ETO10319.1 - 0.5 10.8 13.2 0.061 13.7 2.6 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Jnk-SapK_ap_N PF09744.9 ETO10319.1 - 0.55 10.4 13.5 1.9 8.7 13.2 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 GTP-bdg_M PF16360.5 ETO10319.1 - 0.67 10.6 5.7 1.8 9.2 0.3 2.7 2 1 0 2 2 2 0 GTP-binding GTPase Middle Region DUF4201 PF13870.6 ETO10319.1 - 0.67 9.7 16.2 1.7 8.4 16.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF1664 PF07889.12 ETO10319.1 - 0.83 9.7 15.0 0.96 9.5 8.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF5082 PF16888.5 ETO10319.1 - 0.83 9.9 21.0 22 5.3 1.0 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF5082) DUF724 PF05266.14 ETO10319.1 - 0.89 9.3 13.5 4 7.2 1.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Filament PF00038.21 ETO10319.1 - 1.2 8.7 17.8 0.28 10.7 10.0 2.1 1 1 0 2 2 2 0 Intermediate filament protein PRKG1_interact PF15898.5 ETO10319.1 - 1.3 10.0 12.1 3.7 8.5 2.7 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain HMMR_N PF15905.5 ETO10319.1 - 1.3 8.4 20.7 0.45 9.9 11.5 2.2 1 1 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal GPS2_interact PF15784.5 ETO10319.1 - 1.4 9.4 10.9 0.094 13.2 2.3 3.0 1 1 1 3 3 3 0 G-protein pathway suppressor 2-interacting domain DUF2570 PF10828.8 ETO10319.1 - 1.5 8.7 16.8 2.9 7.8 1.8 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2570) Mvb12 PF09452.10 ETO10319.1 - 1.6 9.2 8.7 16 6.0 0.5 3.6 2 1 0 3 3 3 0 ESCRT-I subunit Mvb12 Cep57_CLD_2 PF14197.6 ETO10319.1 - 1.7 8.8 10.8 13 5.9 1.0 3.2 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 Prefoldin_2 PF01920.20 ETO10319.1 - 1.8 8.6 20.5 3.2 7.8 1.7 3.7 2 1 2 4 4 4 0 Prefoldin subunit CC2-LZ PF16516.5 ETO10319.1 - 3 8.3 17.1 3.4 8.1 2.0 3.1 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator Seryl_tRNA_N PF02403.22 ETO10319.1 - 6.5 7.0 20.3 13 6.1 2.4 2.8 1 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain UPF0242 PF06785.11 ETO10319.1 - 6.9 6.7 21.0 6.4 6.8 13.3 3.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus GSH_synthase PF03199.15 ETO10320.1 - 0.11 13.0 1.8 0.81 10.2 0.6 3.0 2 0 0 2 2 2 0 Eukaryotic glutathione synthase DASH_Dad4 PF08650.10 ETO10320.1 - 0.91 9.5 0.0 0.91 9.5 0.0 3.9 4 1 1 5 5 5 0 DASH complex subunit Dad4 DUF4407 PF14362.6 ETO10320.1 - 2.2 7.6 19.8 0.11 11.9 6.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FCH PF00611.23 ETO10320.1 - 3 8.2 15.8 0.23 11.8 1.1 4.0 4 1 0 4 4 4 0 Fes/CIP4, and EFC/F-BAR homology domain Nucleoside_tran PF01733.18 ETO10320.1 - 7.7 5.8 10.3 1.7 8.0 0.5 2.8 2 1 0 2 2 2 0 Nucleoside transporter Reoviridae_Vp9 PF08978.10 ETO10320.1 - 9.5 5.3 8.4 0.27 10.4 0.7 2.0 2 0 0 2 2 2 0 Reoviridae VP9 Pkinase PF00069.25 ETO10321.1 - 7e-48 163.3 0.6 9e-48 162.9 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10321.1 - 8.5e-29 100.6 0.2 1e-28 100.3 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO10321.1 - 1.4e-05 24.6 0.1 2.2e-05 23.9 0.1 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO10321.1 - 2.7e-05 23.6 0.2 0.015 14.7 0.0 2.1 1 1 1 2 2 2 2 Kinase-like Tom37_C PF11801.8 ETO10322.1 - 4.7 7.2 11.4 0.22 11.5 0.2 3.0 2 1 0 3 3 3 0 Tom37 C-terminal domain Pep1_7 PF17232.2 ETO10325.1 - 0.0079 16.6 0.6 0.015 15.7 0.6 1.5 1 0 0 1 1 1 1 Elicitor peptide 1-7 rRNA_processing PF08524.11 ETO10325.1 - 0.011 15.8 4.6 0.016 15.3 4.6 1.3 1 0 0 1 1 1 0 rRNA processing Ank_2 PF12796.7 ETO10326.1 - 4.3e-35 120.1 0.1 1.2e-13 51.4 0.0 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO10326.1 - 2.3e-28 98.2 0.0 2.3e-08 34.4 0.0 5.3 2 2 5 7 7 7 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO10326.1 - 5.7e-26 87.7 0.2 0.00034 20.8 0.0 6.8 7 0 0 7 7 7 5 Ankyrin repeat Ank PF00023.30 ETO10326.1 - 9.5e-24 82.8 0.1 0.00038 20.8 0.0 6.2 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ETO10326.1 - 4.7e-19 68.2 0.0 1.3e-06 28.5 0.0 4.8 2 1 3 5 5 5 3 Ankyrin repeats (many copies) A1_Propeptide PF07966.12 ETO10327.1 - 0.16 11.9 1.2 0.46 10.4 0.3 2.2 2 0 0 2 2 2 0 A1 Propeptide PNP_UDP_1 PF01048.20 ETO10329.1 - 6.7e-08 32.1 0.0 0.00041 19.7 0.0 2.0 2 0 0 2 2 2 2 Phosphorylase superfamily DUF5644 PF18712.1 ETO10329.1 - 0.099 12.7 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5644) DUF742 PF05331.11 ETO10329.1 - 0.14 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF742) Peptidase_M54 PF07998.11 ETO10330.1 - 7.5e-15 55.4 1.2 3.9e-14 53.1 0.1 2.2 2 0 0 2 2 2 1 Peptidase family M54 Reprolysin_5 PF13688.6 ETO10330.1 - 0.0016 18.7 0.0 0.0026 18.0 0.0 1.4 1 0 0 1 1 1 1 Metallo-peptidase family M12 Peptidase_M10 PF00413.24 ETO10330.1 - 0.0043 16.9 0.1 0.0065 16.3 0.1 1.4 1 1 0 1 1 1 1 Matrixin Reprolysin_3 PF13582.6 ETO10330.1 - 0.019 15.5 1.8 0.045 14.3 0.4 2.2 2 1 1 3 3 3 0 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ETO10330.1 - 0.052 13.2 0.0 0.088 12.4 0.0 1.3 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like Peptidase_M57 PF12388.8 ETO10330.1 - 0.059 13.0 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 Dual-action HEIGH metallo-peptidase DUF4953 PF16313.5 ETO10330.1 - 0.083 12.1 0.1 0.14 11.3 0.1 1.3 1 0 0 1 1 1 0 Met-zincin Metallopep PF12044.8 ETO10330.1 - 0.091 11.3 0.4 0.17 10.5 0.4 1.3 1 0 0 1 1 1 0 Putative peptidase family MIEAP PF16026.5 ETO10331.1 - 2.3e-09 37.8 2.3 3.8e-09 37.0 0.8 1.9 1 1 0 1 1 1 1 Mitochondria-eating protein HTH_ABP1_N PF18107.1 ETO10331.1 - 0.47 10.2 3.5 0.55 10.0 0.8 2.2 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain TPR_12 PF13424.6 ETO10332.1 - 2.5e-76 252.0 5.8 1.6e-19 70.0 0.0 5.7 2 1 3 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10332.1 - 4.7e-65 213.9 0.0 1e-10 41.1 0.0 7.6 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10332.1 - 3.8e-49 162.6 35.7 1.2e-08 34.4 0.4 8.4 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10332.1 - 3.4e-48 158.2 6.7 4.4e-07 29.5 0.0 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10332.1 - 3.7e-44 145.2 36.2 8.5e-08 31.8 0.7 7.7 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10332.1 - 2.8e-43 142.6 24.0 7e-06 25.8 0.8 8.0 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO10332.1 - 3.4e-23 80.3 6.9 0.014 15.7 0.0 8.3 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO10332.1 - 6.7e-22 77.9 0.0 0.01 16.5 0.0 6.6 5 2 2 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO10332.1 - 6e-15 54.8 2.5 0.06 14.0 0.2 7.4 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO10332.1 - 8e-13 48.1 0.0 0.055 14.3 0.0 6.8 6 2 2 8 8 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10332.1 - 5.9e-12 45.1 37.5 0.00041 20.0 4.9 9.3 4 2 3 7 7 7 3 TPR repeat TPR_MalT PF17874.1 ETO10332.1 - 2.2e-11 43.7 0.0 7.7e-07 28.8 0.0 2.4 1 1 1 2 2 2 2 MalT-like TPR region Peptidase_C14 PF00656.22 ETO10332.1 - 1.7e-09 38.0 0.5 4e-09 36.8 0.5 1.6 1 1 0 1 1 1 1 Caspase domain SNAP PF14938.6 ETO10332.1 - 4.4e-09 36.2 3.2 0.03 13.7 0.3 3.6 1 1 1 3 3 3 3 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO10332.1 - 8e-08 32.2 31.3 0.048 13.7 0.9 7.4 6 1 1 7 7 7 4 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO10332.1 - 8.9e-08 32.1 10.8 1.4 8.8 0.0 6.8 7 0 0 7 7 7 3 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO10332.1 - 2.9e-07 30.4 21.2 1.4 8.9 0.3 7.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO10332.1 - 1.4e-06 28.7 0.6 0.37 11.3 0.0 4.6 2 1 4 6 6 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO10332.1 - 3.8e-06 26.3 1.8 2.4 7.7 0.0 5.9 6 0 0 6 6 6 1 SHNi-TPR PPR PF01535.20 ETO10332.1 - 2.1e-05 24.4 9.3 0.47 10.8 0.1 7.3 8 0 0 8 8 7 1 PPR repeat Sel1 PF08238.12 ETO10332.1 - 3.8e-05 24.2 7.7 44 5.0 0.1 7.5 8 0 0 8 8 7 0 Sel1 repeat ANAPC3 PF12895.7 ETO10332.1 - 0.0004 20.5 15.5 0.73 10.1 0.4 5.9 2 1 6 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 RPN7 PF10602.9 ETO10332.1 - 0.015 15.0 13.7 3.6 7.2 0.1 5.9 2 1 3 6 6 6 0 26S proteasome subunit RPN7 14-3-3 PF00244.20 ETO10332.1 - 0.057 12.9 6.4 0.066 12.7 0.1 3.8 2 2 3 5 5 5 0 14-3-3 protein DUF4810 PF16068.5 ETO10332.1 - 0.13 12.8 7.9 14 6.3 0.2 5.7 4 3 0 4 4 4 0 Domain of unknown function (DUF4810) TPR_21 PF09976.9 ETO10332.1 - 0.17 11.5 4.3 0.37 10.5 0.0 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat-like domain DUF3450 PF11932.8 ETO10332.1 - 1.7 7.9 3.8 2.9 7.1 0.0 2.9 3 1 1 4 4 3 0 Protein of unknown function (DUF3450) Fis1_TPR_C PF14853.6 ETO10332.1 - 5.3 7.2 20.6 2 8.5 0.1 6.1 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat ERM PF00769.19 ETO10333.1 - 2.2e-05 24.4 16.6 3.8e-05 23.6 16.6 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family ATG16 PF08614.11 ETO10333.1 - 0.00041 20.6 25.7 0.00041 20.6 25.7 1.5 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) Spc7 PF08317.11 ETO10333.1 - 0.12 11.3 28.1 0.15 10.9 27.0 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein Bacillus_HBL PF05791.11 ETO10333.1 - 0.19 11.5 23.1 0.12 12.2 10.6 2.3 1 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) HMMR_N PF15905.5 ETO10333.1 - 0.21 11.0 27.5 0.1 12.0 22.3 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal EzrA PF06160.12 ETO10333.1 - 0.4 8.8 21.8 0.13 10.4 13.2 1.9 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA CENP-F_leu_zip PF10473.9 ETO10333.1 - 0.61 10.1 29.2 0.88 9.6 16.6 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 YafQ_toxin PF15738.5 ETO10333.1 - 1.2 9.5 6.0 0.32 11.4 1.5 2.3 1 1 1 2 2 2 0 Bacterial toxin of type II toxin-antitoxin system, YafQ Fib_alpha PF08702.10 ETO10333.1 - 1.3 9.2 29.0 0.69 10.1 19.2 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF812 PF05667.11 ETO10333.1 - 1.4 7.7 27.0 1.1 8.1 25.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DUF4887 PF16228.5 ETO10333.1 - 1.5 9.0 19.6 3.2 7.9 19.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) OmpH PF03938.14 ETO10333.1 - 1.8 8.9 29.3 0.85 10.0 7.7 2.3 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) zf-RING-like PF08746.11 ETO10333.1 - 3.5 8.0 9.0 0.38 11.1 1.4 2.9 1 1 1 2 2 2 0 RING-like domain FliJ PF02050.16 ETO10333.1 - 5.8 7.2 34.3 0.4 10.9 15.5 2.8 1 1 0 2 2 2 0 Flagellar FliJ protein FUSC PF04632.12 ETO10333.1 - 6.3 5.2 4.5 10 4.5 4.5 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family IFT57 PF10498.9 ETO10333.1 - 6.5 5.6 27.8 1.7 7.5 19.4 2.2 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Pkinase PF00069.25 ETO10334.1 - 1.1e-53 182.3 0.0 2e-53 181.5 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10334.1 - 2.6e-27 95.7 0.0 4.8e-27 94.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ETO10334.1 - 2e-07 31.6 1.5 4.7e-07 30.4 1.5 1.6 1 0 0 1 1 1 1 Protein kinase C terminal domain Kdo PF06293.14 ETO10334.1 - 0.00069 19.0 0.4 0.0014 18.0 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO10334.1 - 0.0039 16.5 0.5 0.14 11.5 0.1 2.5 2 1 0 2 2 2 1 Kinase-like RNase_P_Rpp14 PF01900.19 ETO10335.1 - 0.025 14.8 0.0 0.17 12.1 0.0 2.4 2 1 0 2 2 2 0 Rpp14/Pop5 family DUF3921 PF13060.6 ETO10335.1 - 0.045 13.8 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3921) DUF2615 PF11027.8 ETO10336.1 - 0.12 12.6 0.3 0.12 12.6 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) SARAF PF06682.12 ETO10336.1 - 0.5 10.0 4.6 0.96 9.0 4.6 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Tim54 PF11711.8 ETO10338.1 - 0.0092 14.8 0.3 0.011 14.6 0.3 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Menin PF05053.13 ETO10338.1 - 0.056 11.8 3.0 0.059 11.7 3.0 1.1 1 0 0 1 1 1 0 Menin NST1 PF13945.6 ETO10338.1 - 0.46 10.6 13.8 0.71 9.9 13.8 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Corazonin PF17308.2 ETO10338.1 - 2.8 8.3 15.8 5.3 7.4 15.8 1.4 1 0 0 1 1 1 0 Pro-corazonin Orf78 PF06024.12 ETO10338.1 - 6.2 7.2 10.6 9.3 6.6 9.4 1.8 2 0 0 2 2 2 0 Orf78 (ac78) Mito_fiss_reg PF05308.11 ETO10338.1 - 9.6 6.2 15.1 3.7 7.6 12.7 1.5 1 1 1 2 2 2 0 Mitochondrial fission regulator WD40 PF00400.32 ETO10340.1 - 3.2e-57 189.2 10.8 5.6e-09 36.5 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10340.1 - 9.9e-19 67.4 0.4 0.0042 17.4 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10340.1 - 4.8e-12 45.5 3.4 0.076 12.0 0.0 6.1 2 1 5 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO10340.1 - 1.1e-08 35.2 0.1 0.012 15.5 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO10340.1 - 2.2e-08 33.8 0.0 0.083 12.2 0.0 3.2 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO10340.1 - 2.2e-06 26.6 5.7 0.54 8.8 0.0 5.5 2 2 4 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO10340.1 - 4.2e-05 22.2 0.6 0.54 8.7 0.0 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain SGL PF08450.12 ETO10340.1 - 0.022 14.4 0.3 0.98 8.9 0.2 2.9 1 1 2 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Marek_SORF3 PF07153.11 ETO10340.1 - 0.05 12.9 0.0 0.14 11.4 0.0 1.8 1 1 1 2 2 2 0 Marek's disease-like virus SORF3 protein DUF5570 PF17731.1 ETO10340.1 - 0.068 13.3 1.2 3.9 7.6 0.0 3.7 1 1 3 5 5 5 0 Family of unknown function (DUF5570) NHL PF01436.21 ETO10340.1 - 0.18 11.9 3.9 0.93 9.6 0.1 3.4 4 0 0 4 4 4 0 NHL repeat Proteasome_A_N PF10584.9 ETO10340.1 - 0.53 10.0 7.0 16 5.3 0.1 4.4 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Thioredoxin_6 PF13848.6 ETO10341.1 - 2.3e-18 66.7 0.9 7.9e-17 61.8 0.0 2.8 3 0 0 3 3 3 1 Thioredoxin-like domain Peptidase_M61 PF05299.12 ETO10341.1 - 0.003 18.0 0.1 0.015 15.7 0.0 2.0 2 0 0 2 2 2 1 M61 glycyl aminopeptidase DUF3295 PF11702.8 ETO10341.1 - 4.3 6.6 17.3 0.16 11.3 10.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) DUF3522 PF12036.8 ETO10343.1 - 0.001 19.4 0.5 0.0018 18.6 0.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) PTPA PF03095.15 ETO10344.1 - 1.9e-22 80.1 1.1 1.6e-17 64.0 0.1 2.2 2 0 0 2 2 2 2 Phosphotyrosyl phosphate activator (PTPA) protein DUF3439 PF11921.8 ETO10345.1 - 0.086 12.8 1.4 0.12 12.3 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Ferlin_C PF16165.5 ETO10345.1 - 2.1 8.3 3.6 3.1 7.7 3.6 1.2 1 0 0 1 1 1 0 Ferlin C-terminus NPR3 PF03666.13 ETO10345.1 - 3.3 6.4 8.0 3.7 6.2 8.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 NFACT-C PF11923.8 ETO10346.1 - 2.8e-15 56.1 1.1 2.8e-15 56.1 1.1 5.1 2 2 2 4 4 4 1 NFACT protein C-terminal domain NFACT-R_1 PF05670.13 ETO10346.1 - 0.0064 17.1 0.0 0.0064 17.1 0.0 3.2 3 0 0 3 3 3 1 NFACT protein RNA binding domain NFACT-R_1 PF05670.13 ETO10347.1 - 1.5e-05 25.6 0.2 0.00013 22.6 0.0 2.5 2 0 0 2 2 2 1 NFACT protein RNA binding domain CDC45 PF02724.14 ETO10347.1 - 0.0019 16.6 4.2 0.0019 16.6 4.2 3.3 2 1 1 3 3 3 1 CDC45-like protein DUF4637 PF15470.6 ETO10347.1 - 0.0043 16.8 4.8 0.0043 16.8 4.8 3.8 3 1 0 3 3 3 1 Domain of unknown function (DUF4637) DUF3175 PF11373.8 ETO10347.1 - 0.032 14.4 5.4 4.8 7.4 0.2 4.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3175) Sigma70_ner PF04546.13 ETO10347.1 - 0.27 11.1 50.9 0.027 14.3 7.5 4.1 2 1 1 3 3 3 0 Sigma-70, non-essential region DUF5590 PF17881.1 ETO10347.1 - 0.38 10.9 5.2 1.7 8.7 0.1 4.2 4 1 0 4 4 4 0 Domain of unknown function (DUF5590) DUF1664 PF07889.12 ETO10347.1 - 0.95 9.5 5.7 0.81 9.7 0.4 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) FAM176 PF14851.6 ETO10347.1 - 0.99 9.1 44.9 0.23 11.1 3.6 5.4 5 1 0 5 5 5 0 FAM176 family RXT2_N PF08595.11 ETO10347.1 - 1.1 9.2 30.3 0.42 10.6 6.8 4.0 3 0 0 3 3 3 0 RXT2-like, N-terminal DUF948 PF06103.11 ETO10347.1 - 5.5 7.3 6.2 5.5 7.3 1.1 2.9 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.32 ETO10351.1 - 0.00011 22.9 0.3 0.74 10.8 0.0 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10351.1 - 0.011 16.0 0.0 5.2 7.4 0.0 2.6 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Lipocalin PF00061.23 ETO10352.1 - 0.00048 20.3 0.9 0.00048 20.3 0.9 1.9 1 1 1 2 2 2 1 Lipocalin / cytosolic fatty-acid binding protein family Orthopox_F14 PF06076.12 ETO10354.1 - 0.053 13.8 1.0 0.09 13.1 1.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus F14 protein GlcNAc PF11397.8 ETO10355.1 - 1.1e-45 156.7 0.0 3.1e-28 99.3 0.0 3.1 2 1 0 2 2 2 2 Glycosyltransferase (GlcNAc) Abhydrolase_9_N PF15420.6 ETO10356.1 - 0.00079 19.5 1.9 0.014 15.4 0.3 2.3 2 0 0 2 2 2 2 Alpha/beta-hydrolase family N-terminus UPF0242 PF06785.11 ETO10356.1 - 0.17 12.0 0.3 0.27 11.3 0.3 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Lactamase_B PF00753.27 ETO10357.1 - 5.9e-10 39.5 0.1 0.00086 19.4 0.0 2.2 1 1 1 2 2 2 2 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETO10357.1 - 0.042 13.4 0.1 0.086 12.3 0.0 1.4 1 1 0 1 1 1 0 Beta-lactamase superfamily domain COG5 PF10392.9 ETO10358.1 - 0.00025 21.2 0.9 0.0005 20.2 0.6 1.6 1 1 1 2 2 2 1 Golgi transport complex subunit 5 LPP PF04728.13 ETO10358.1 - 0.00072 19.9 1.0 0.0025 18.2 0.1 2.2 2 1 1 3 3 2 1 Lipoprotein leucine-zipper Spc7 PF08317.11 ETO10358.1 - 0.0051 15.7 9.0 0.0063 15.4 9.0 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein CALCOCO1 PF07888.11 ETO10358.1 - 0.016 14.1 2.9 0.019 13.8 2.9 1.3 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like YabA PF06156.13 ETO10358.1 - 0.018 15.7 9.0 0.035 14.8 4.2 2.2 1 1 1 2 2 2 0 Initiation control protein YabA Ribosomal_L17 PF01196.19 ETO10358.1 - 0.022 15.6 0.2 0.031 15.2 0.2 1.3 1 0 0 1 1 1 0 Ribosomal protein L17 Apolipoprotein PF01442.18 ETO10358.1 - 0.022 14.6 2.7 0.057 13.3 2.2 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain GCN5L1 PF06320.13 ETO10358.1 - 0.024 14.8 3.4 0.027 14.6 2.9 1.4 1 1 0 1 1 1 0 GCN5-like protein 1 (GCN5L1) APG6_N PF17675.1 ETO10358.1 - 0.026 15.1 9.2 0.033 14.7 9.2 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETO10358.1 - 0.051 13.6 3.6 0.093 12.8 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) MscS_porin PF12795.7 ETO10358.1 - 0.063 12.8 6.6 0.085 12.4 6.5 1.3 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF2408 PF10303.9 ETO10358.1 - 0.063 13.8 3.8 0.045 14.3 2.3 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) V_ATPase_I PF01496.19 ETO10358.1 - 0.087 10.7 5.8 0.089 10.7 5.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Prominin PF05478.11 ETO10358.1 - 0.099 10.6 6.5 0.11 10.4 6.5 1.0 1 0 0 1 1 1 0 Prominin HIP1_clath_bdg PF16515.5 ETO10358.1 - 0.18 12.4 8.1 0.27 11.9 8.1 1.4 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF948 PF06103.11 ETO10358.1 - 0.19 12.0 1.7 0.31 11.3 1.3 1.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DHR10 PF18595.1 ETO10358.1 - 0.19 11.8 7.5 0.045 13.8 2.9 1.9 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain ESM4 PF15952.5 ETO10358.1 - 0.21 12.0 4.3 0.23 11.8 4.3 1.1 1 0 0 1 1 1 0 Enhancer of split M4 family SlyX PF04102.12 ETO10358.1 - 0.41 11.3 4.8 0.53 10.9 0.3 2.4 1 1 1 2 2 2 0 SlyX TMF_TATA_bd PF12325.8 ETO10358.1 - 0.86 9.8 8.5 0.72 10.1 2.2 2.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Exonuc_VII_L PF02601.15 ETO10358.1 - 0.89 9.1 4.8 0.93 9.0 4.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit HSBP1 PF06825.12 ETO10358.1 - 2.5 8.0 9.5 2.3 8.1 0.7 2.9 3 0 0 3 3 3 0 Heat shock factor binding protein 1 DivIC PF04977.15 ETO10358.1 - 2.7 7.8 9.3 0.11 12.3 3.1 2.1 3 0 0 3 3 2 0 Septum formation initiator Fib_alpha PF08702.10 ETO10358.1 - 3.2 8.0 9.5 7.5 6.7 4.0 1.9 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TolA_bind_tri PF16331.5 ETO10358.1 - 4.3 7.5 9.7 0.27 11.3 3.0 2.2 2 1 0 2 2 2 0 TolA binding protein trimerisation Cnn_1N PF07989.11 ETO10358.1 - 8.7 6.6 16.9 3.5 7.9 12.2 2.5 2 1 0 2 2 1 0 Centrosomin N-terminal motif 1 DUF2538 PF10804.8 ETO10359.1 - 0.097 12.4 0.3 0.47 10.2 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2538) DUF2089 PF09862.9 ETO10359.1 - 0.12 12.4 0.4 0.24 11.5 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2089) eIF3_subunit PF08597.10 ETO10359.1 - 5.6 6.8 8.9 20 5.0 8.9 1.7 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit EMP70 PF02990.16 ETO10360.1 - 2.1e-47 162.0 20.7 2.1e-47 162.0 20.7 1.8 1 1 1 2 2 2 1 Endomembrane protein 70 Exosortase_EpsH PF09721.10 ETO10360.1 - 0.015 14.8 16.1 0.022 14.3 16.1 1.3 1 0 0 1 1 1 0 Transmembrane exosortase (Exosortase_EpsH) Asp PF00026.23 ETO10361.1 - 2.2e-47 162.0 1.9 5.7e-46 157.4 1.9 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO10361.1 - 4.9e-10 39.9 5.2 9.8e-09 35.7 0.2 3.4 3 2 2 5 5 5 2 Xylanase inhibitor N-terminal Asp_protease_2 PF13650.6 ETO10361.1 - 0.003 18.1 0.0 0.0051 17.4 0.0 1.3 1 0 0 1 1 1 1 Aspartyl protease gag-asp_proteas PF13975.6 ETO10361.1 - 0.06 13.9 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Asp PF00026.23 ETO10362.1 - 1.5e-20 73.8 0.1 1.8e-20 73.6 0.1 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Nop14 PF04147.12 ETO10363.1 - 1.3 7.2 17.6 1.7 6.7 17.6 1.1 1 0 0 1 1 1 0 Nop14-like family Chromate_transp PF02417.15 ETO10365.1 - 9.9e-30 103.8 16.7 2e-29 102.8 16.7 1.5 1 0 0 1 1 1 1 Chromate transporter Phage_r1t_holin PF16945.5 ETO10365.1 - 0.023 14.9 0.5 0.052 13.7 0.5 1.7 1 0 0 1 1 1 0 Putative lactococcus lactis phage r1t holin NADH5_C PF06455.11 ETO10365.1 - 2.6 7.6 8.1 0.086 12.4 0.7 2.2 2 1 0 2 2 2 0 NADH dehydrogenase subunit 5 C-terminus Pkinase PF00069.25 ETO10369.1 - 0.0033 16.8 0.0 0.0067 15.8 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO10370.1 - 6.3e-17 61.8 0.9 2.1e-15 56.8 0.4 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10370.1 - 3.3e-09 36.4 1.0 1.7e-08 34.1 0.2 2.4 2 2 1 3 3 3 1 Protein tyrosine kinase Kdo PF06293.14 ETO10370.1 - 0.02 14.2 0.6 0.029 13.7 0.6 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ETO10370.1 - 0.064 12.9 0.4 0.11 12.2 0.1 1.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 ABC_tran PF00005.27 ETO10371.1 - 7e-18 65.5 0.0 1.4e-17 64.4 0.0 1.6 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO10371.1 - 1.7e-06 28.1 0.9 0.026 14.4 0.2 2.3 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO10371.1 - 1.1e-05 25.0 0.0 2.6e-05 23.8 0.0 1.6 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain NB-ARC PF00931.22 ETO10371.1 - 0.0014 17.9 0.2 0.0024 17.1 0.1 1.4 2 0 0 2 2 2 1 NB-ARC domain AAA_33 PF13671.6 ETO10371.1 - 0.0044 17.2 0.1 0.013 15.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO10371.1 - 0.013 16.1 0.1 0.026 15.1 0.1 1.5 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO10371.1 - 0.023 14.6 0.0 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 NACHT domain AAA_17 PF13207.6 ETO10371.1 - 0.024 15.1 0.5 0.072 13.5 0.5 1.8 1 1 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO10371.1 - 0.04 14.4 2.6 0.4 11.2 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ETO10371.1 - 0.048 13.7 0.1 0.18 11.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO10371.1 - 0.06 13.7 0.0 0.073 13.5 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_15 PF13175.6 ETO10371.1 - 0.073 12.8 2.4 3.4 7.3 4.0 2.1 1 1 1 2 2 2 0 AAA ATPase domain PIN7 PF18475.1 ETO10371.1 - 0.074 13.7 0.1 0.65 10.7 0.0 2.2 2 0 0 2 2 2 0 PIN domain AAA_22 PF13401.6 ETO10371.1 - 0.13 12.5 0.0 0.52 10.6 0.1 2.0 1 1 1 2 2 2 0 AAA domain cobW PF02492.19 ETO10371.1 - 0.14 11.8 0.1 0.3 10.7 0.1 1.6 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 ETO10371.1 - 0.15 11.7 0.0 0.34 10.5 0.0 1.6 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ATP-synt_ab PF00006.25 ETO10371.1 - 0.15 11.7 0.0 0.21 11.2 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain HSP70 PF00012.20 ETO10372.1 - 2.2e-201 670.2 5.9 5.7e-138 460.7 0.1 3.0 2 1 1 3 3 3 3 Hsp70 protein MreB_Mbl PF06723.13 ETO10372.1 - 9.5e-11 41.1 0.9 2.6e-07 29.8 0.1 3.1 3 1 0 3 3 3 2 MreB/Mbl protein FtsA PF14450.6 ETO10372.1 - 0.0044 17.4 0.7 1 9.8 0.0 3.0 2 2 0 2 2 2 2 Cell division protein FtsA FGGY_C PF02782.16 ETO10372.1 - 0.023 14.4 0.0 0.048 13.4 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Erf4 PF10256.9 ETO10373.1 - 0.034 14.2 1.5 1.3 9.2 0.0 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 7/ERF4 family ABC_tran PF00005.27 ETO10374.1 - 2.2e-20 73.6 0.1 6.2e-20 72.1 0.0 1.8 2 0 0 2 2 2 1 ABC transporter ABC_tran_Xtn PF12848.7 ETO10374.1 - 3.5e-15 55.8 3.0 5.8e-15 55.1 3.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO10374.1 - 2.2e-07 30.6 0.6 5.9e-07 29.1 0.1 1.9 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO10374.1 - 2.8e-07 30.7 3.6 0.0037 17.1 0.1 2.5 1 1 1 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system MeaB PF03308.16 ETO10374.1 - 0.00022 20.3 0.0 0.00038 19.5 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB DUF87 PF01935.17 ETO10374.1 - 0.013 15.6 0.5 0.031 14.3 0.1 1.8 3 0 0 3 3 3 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 ETO10374.1 - 0.014 15.4 0.2 0.029 14.5 0.2 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 ETO10374.1 - 0.016 15.3 0.0 0.043 14.0 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO10374.1 - 0.021 14.6 0.1 0.046 13.5 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 ETO10374.1 - 0.024 15.2 0.0 1.2 9.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO10374.1 - 0.06 13.7 0.0 0.16 12.4 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain GTP_EFTU PF00009.27 ETO10374.1 - 0.068 12.7 0.4 0.33 10.5 0.0 2.2 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ETO10374.1 - 0.092 13.0 0.0 0.34 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain L_biotic_typeA PF04604.13 ETO10374.1 - 0.2 11.5 0.5 0.64 9.9 0.0 2.1 2 0 0 2 2 2 0 Type-A lantibiotic AAA_23 PF13476.6 ETO10374.1 - 1.5 9.2 4.6 0.81 10.2 0.2 2.4 3 0 0 3 3 3 0 AAA domain AAA_15 PF13175.6 ETO10374.1 - 2.4 7.8 5.1 1.2 8.8 0.9 2.5 2 1 1 3 3 3 0 AAA ATPase domain Metallophos PF00149.28 ETO10375.1 - 7.3e-28 98.5 0.0 1.3e-27 97.7 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PPP5 PF08321.12 ETO10375.1 - 0.0011 19.2 0.0 0.0029 17.9 0.0 1.7 1 0 0 1 1 1 1 PPP5 TPR repeat region Glyco_transf_4 PF13439.6 ETO10375.1 - 0.0073 16.3 0.0 0.015 15.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyltransferase Family 4 COG5 PF10392.9 ETO10376.1 - 0.0083 16.3 1.6 0.012 15.8 1.6 1.4 1 0 0 1 1 1 1 Golgi transport complex subunit 5 SPAR_C PF11881.8 ETO10376.1 - 0.013 15.4 3.8 0.018 15.0 3.8 1.1 1 0 0 1 1 1 0 C-terminal domain of SPAR protein DUF4208 PF13907.6 ETO10376.1 - 0.088 13.2 2.1 0.18 12.3 1.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4208) PCYCGC PF13798.6 ETO10376.1 - 0.18 11.6 0.2 0.18 11.6 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function with PCYCGC motif Spc7 PF08317.11 ETO10376.1 - 0.22 10.3 10.5 0.25 10.2 10.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein HEPN_Swt1 PF18731.1 ETO10376.1 - 0.4 11.0 7.2 0.36 11.2 0.9 2.1 1 1 0 2 2 2 0 Swt1-like HEPN DUF4407 PF14362.6 ETO10376.1 - 0.44 9.8 7.1 0.54 9.6 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FlxA PF14282.6 ETO10376.1 - 0.76 9.8 16.2 2.8 8.0 15.3 2.0 1 1 0 1 1 1 0 FlxA-like protein Atg14 PF10186.9 ETO10376.1 - 1.2 8.2 7.3 1.5 7.8 7.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HSP70 PF00012.20 ETO10376.1 - 1.5 6.9 9.6 1.8 6.6 9.6 1.3 1 0 0 1 1 1 0 Hsp70 protein DUF643 PF04867.12 ETO10376.1 - 1.5 9.4 10.1 0.25 11.9 3.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF643) Histone_HNS PF00816.21 ETO10376.1 - 1.8 9.5 6.8 0.4 11.5 2.2 2.1 1 1 2 3 3 3 0 H-NS histone family PDE4_UCR PF18100.1 ETO10376.1 - 6.8 7.4 10.8 0.55 10.9 2.4 2.6 1 1 1 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) Ndc1_Nup PF09531.10 ETO10377.1 - 1.3 7.6 18.0 1.6 7.3 18.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF572 PF04502.13 ETO10377.1 - 2 8.0 33.8 2.6 7.6 33.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) DUF4551 PF15087.6 ETO10377.1 - 4.9 5.9 16.8 5.5 5.7 16.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RasGEF PF00617.19 ETO10378.1 - 9e-33 113.9 4.4 1.2e-32 113.5 4.4 1.2 1 0 0 1 1 1 1 RasGEF domain NADase_NGA PF07461.11 ETO10378.1 - 0.056 12.3 1.4 0.72 8.7 0.1 2.1 2 0 0 2 2 2 0 Nicotine adenine dinucleotide glycohydrolase (NADase) Glyco_transf_64 PF09258.10 ETO10379.1 - 1.1e-19 70.8 0.7 7.9e-19 67.9 0.7 2.0 1 1 0 1 1 1 1 Glycosyl transferase family 64 domain Pkinase PF00069.25 ETO10380.1 - 1.3e-07 31.3 0.1 9.8e-07 28.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain DUF148 PF02520.17 ETO10380.1 - 0.24 11.5 8.2 0.15 12.2 1.9 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF148 Presenilin PF01080.17 ETO10382.1 - 0.0092 14.8 0.0 0.012 14.4 0.0 1.1 1 0 0 1 1 1 1 Presenilin PetM PF08041.11 ETO10382.1 - 0.13 11.9 0.1 0.19 11.4 0.1 1.2 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 AAA_12 PF13087.6 ETO10383.1 - 6.1e-40 137.0 0.1 5.1e-24 85.0 0.0 2.0 1 1 1 2 2 2 2 AAA domain ABC_tran PF00005.27 ETO10385.1 - 3.7e-27 95.5 0.6 6.6e-27 94.7 0.6 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO10385.1 - 2.4e-13 50.6 1.1 7.2e-10 39.2 1.1 2.4 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO10385.1 - 2e-05 24.2 2.0 6.8e-05 22.4 2.0 1.8 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO10385.1 - 0.008 16.7 7.8 0.034 14.7 7.8 2.3 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETO10385.1 - 0.015 15.1 0.1 2.8 7.6 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_29 PF13555.6 ETO10385.1 - 0.016 14.9 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO10385.1 - 0.03 14.2 0.1 0.052 13.4 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase SbcCD_C PF13558.6 ETO10385.1 - 0.032 14.5 0.1 0.38 11.0 0.0 2.8 3 1 0 3 3 2 0 Putative exonuclease SbcCD, C subunit RCC1_2 PF13540.6 ETO10385.1 - 0.073 12.9 0.0 0.22 11.3 0.0 1.8 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat SRP54 PF00448.22 ETO10385.1 - 0.086 12.5 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain TsaE PF02367.17 ETO10385.1 - 0.15 12.1 0.2 0.33 11.0 0.2 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF1673 PF07895.11 ETO10385.1 - 0.19 11.4 1.5 0.41 10.3 1.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Secretin_N_2 PF07655.13 ETO10385.1 - 0.25 11.9 6.5 0.66 10.6 6.5 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain LMBR1 PF04791.16 ETO10386.1 - 0.0024 16.8 2.9 0.0028 16.6 2.9 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Cnn_1N PF07989.11 ETO10387.1 - 0.11 12.7 29.2 3.4 7.9 11.5 5.1 2 1 0 3 3 3 0 Centrosomin N-terminal motif 1 UCR_hinge PF02320.16 ETO10387.1 - 4.4 7.6 20.0 0.38 11.0 3.5 3.6 2 1 2 4 4 4 0 Ubiquinol-cytochrome C reductase hinge protein ATG16 PF08614.11 ETO10387.1 - 5.8 7.1 33.9 1.3 9.2 12.6 2.7 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 ETO10387.1 - 8.3 6.7 31.3 5.4 7.3 6.2 3.8 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding Csm1_N PF18504.1 ETO10387.1 - 9.4 6.7 27.3 1.6 9.2 6.9 4.5 3 2 1 4 4 4 0 Csm1 N-terminal domain BTB PF00651.31 ETO10388.1 - 2.8e-12 46.8 2.3 1.3e-11 44.7 0.8 2.2 2 0 0 2 2 2 1 BTB/POZ domain Gaa1 PF04114.14 ETO10389.1 - 0.063 12.3 0.5 0.085 11.9 0.5 1.1 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component MFS_1 PF07690.16 ETO10390.1 - 0.0044 16.0 3.2 0.011 14.6 1.9 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily Nodulin-like PF06813.13 ETO10391.1 - 4.5e-19 68.9 22.5 7.5e-19 68.2 9.1 3.0 3 0 0 3 3 3 3 Nodulin-like SieB PF14163.6 ETO10391.1 - 1 8.8 6.0 2.4 7.7 0.5 3.1 3 0 0 3 3 3 0 Super-infection exclusion protein B Dev_Cell_Death PF10539.9 ETO10394.1 - 3.5e-20 72.2 0.0 9.3e-20 70.8 0.0 1.8 2 0 0 2 2 2 1 Development and cell death domain PRIMA1 PF16101.5 ETO10394.1 - 0.057 13.4 0.9 0.057 13.4 0.9 2.8 2 1 0 3 3 3 0 Proline-rich membrane anchor 1 YtxC PF08812.11 ETO10394.1 - 0.22 11.1 0.1 0.34 10.5 0.1 1.2 1 0 0 1 1 1 0 YtxC-like family Dicty_REP PF05086.12 ETO10394.1 - 3 5.7 11.2 3.8 5.4 11.2 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO10395.1 - 1.6 8.7 19.8 8.4 6.4 19.8 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SlyX PF04102.12 ETO10396.1 - 0.038 14.6 8.0 1.3 9.7 0.7 3.4 2 0 0 2 2 2 0 SlyX DASH_Dad1 PF08649.10 ETO10396.1 - 1.6 9.0 6.6 8.6 6.6 0.2 3.9 4 0 0 4 4 4 0 DASH complex subunit Dad1 Prefoldin_2 PF01920.20 ETO10396.1 - 1.9 8.5 16.9 2.6 8.0 8.2 4.3 2 1 1 3 3 3 0 Prefoldin subunit TSNAXIP1_N PF15739.5 ETO10396.1 - 2.3 8.6 10.1 4.6 7.7 1.8 3.3 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus LicD PF04991.13 ETO10400.1 - 0.58 10.2 6.1 0.7 10.0 3.4 2.0 2 0 0 2 2 2 0 LicD family CrgA PF06781.12 ETO10400.1 - 0.68 10.0 4.7 1 9.5 0.0 3.3 3 1 1 4 4 4 0 Cell division protein CrgA WD40 PF00400.32 ETO10401.1 - 4.2e-12 46.4 2.5 0.0001 23.0 0.2 3.7 3 2 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO10401.1 - 0.0016 17.1 0.3 0.5 8.9 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 BLM10_mid PF16507.5 ETO10402.1 - 0.028 13.1 0.2 0.043 12.5 0.2 1.3 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region DUF3139 PF11337.8 ETO10402.1 - 0.055 14.1 3.4 0.11 13.1 3.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) EphA2_TM PF14575.6 ETO10402.1 - 0.1 13.5 1.2 0.14 13.1 0.2 1.8 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.11 ETO10402.1 - 1.6 8.3 4.9 3 7.5 4.9 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family WD40 PF00400.32 ETO10403.1 - 1.1e-37 127.3 22.2 6.2e-08 33.2 0.5 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10403.1 - 3e-12 46.7 0.2 0.0092 16.3 0.0 4.5 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10403.1 - 3e-09 36.1 6.2 0.065 11.9 0.1 4.9 2 1 3 5 5 5 4 Nucleoporin Nup120/160 MerR_1 PF13411.6 ETO10403.1 - 0.25 11.4 3.6 2.4 8.3 0.0 4.0 6 0 0 6 6 6 0 MerR HTH family regulatory protein TetM_leader PF08076.11 ETO10403.1 - 3.2 7.6 7.7 50 3.8 0.3 4.6 5 0 0 5 5 5 0 Tetracycline resistance determinant leader peptide DUF678 PF05077.12 ETO10403.1 - 7.6 6.7 7.6 3.6 7.8 0.2 3.6 2 1 3 5 5 5 0 Protein of unknown function (DUF678) Connexin PF00029.19 ETO10404.1 - 0.27 10.9 5.8 0.29 10.8 5.8 1.1 1 0 0 1 1 1 0 Connexin DUF4637 PF15470.6 ETO10404.1 - 1.1 9.0 17.8 1.3 8.7 17.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HSP90 PF00183.18 ETO10404.1 - 1.4 7.8 14.9 1.4 7.7 14.9 1.0 1 0 0 1 1 1 0 Hsp90 protein CobT PF06213.12 ETO10404.1 - 2 7.8 18.9 2.2 7.6 18.9 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 ETO10404.1 - 6.8 6.8 9.8 7.7 6.7 9.8 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Paf1 PF03985.13 ETO10404.1 - 8 5.3 22.3 8.7 5.2 22.3 1.0 1 0 0 1 1 1 0 Paf1 Nop14 PF04147.12 ETO10404.1 - 8 4.5 23.7 8.5 4.4 23.7 1.0 1 0 0 1 1 1 0 Nop14-like family TRAP_alpha PF03896.16 ETO10404.1 - 8.8 5.4 10.8 9.9 5.3 10.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FSA_C PF10479.9 ETO10405.1 - 0.23 9.5 16.1 0.31 9.1 16.1 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus LcrG PF07216.12 ETO10406.1 - 0.012 15.6 0.3 0.019 14.9 0.3 1.4 1 0 0 1 1 1 0 LcrG protein PH_10 PF15411.6 ETO10406.1 - 0.072 13.3 0.0 0.083 13.1 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain DUF2500 PF10694.9 ETO10407.1 - 0.028 14.9 0.2 0.061 13.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Cadherin_C_2 PF16492.5 ETO10407.1 - 0.12 13.2 1.2 0.16 12.7 0.3 1.7 2 0 0 2 2 2 0 Cadherin cytoplasmic C-terminal OAD_gamma PF04277.13 ETO10407.1 - 0.17 12.5 0.5 0.37 11.4 0.5 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PEX11 PF05648.14 ETO10407.1 - 1.2 8.6 5.0 4.6 6.6 0.9 2.1 1 1 1 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) YMF19 PF02326.15 ETO10407.1 - 2.8 8.8 8.6 1.1 10.0 4.0 2.2 1 1 1 2 2 2 0 Plant ATP synthase F0 PUL PF08324.11 ETO10408.1 - 7.5e-17 61.5 0.2 1.1e-16 60.9 0.2 1.2 1 0 0 1 1 1 1 PUL domain PFU PF09070.11 ETO10408.1 - 2e-09 37.7 0.0 1.7e-08 34.7 0.0 2.3 2 0 0 2 2 2 1 PFU (PLAA family ubiquitin binding) Med30 PF11315.8 ETO10408.1 - 0.03 14.5 1.1 5.1 7.3 0.0 3.2 4 0 0 4 4 4 0 Mediator complex subunit 30 DEP PF00610.21 ETO10409.1 - 2.8e-40 136.2 2.5 4e-19 68.4 0.1 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) zf-Di19 PF05605.12 ETO10409.1 - 0.056 13.7 1.3 2.7 8.4 0.2 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding MCPVI PF02993.14 ETO10409.1 - 0.058 13.2 0.1 0.2 11.5 0.1 1.7 2 0 0 2 2 2 0 Minor capsid protein VI MinE PF03776.14 ETO10409.1 - 0.079 13.0 1.9 11 6.1 0.5 2.6 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE IDEAL PF08858.10 ETO10409.1 - 0.15 11.8 3.6 3.4 7.5 0.5 2.5 2 0 0 2 2 2 0 IDEAL domain DEP PF00610.21 ETO10410.1 - 1.9e-16 59.9 2.2 9e-12 44.9 0.0 3.3 3 0 0 3 3 3 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CAP_GLY PF01302.25 ETO10411.1 - 0.00062 19.7 0.1 0.0015 18.5 0.1 1.6 1 0 0 1 1 1 1 CAP-Gly domain DUF966 PF06136.13 ETO10411.1 - 0.12 12.0 30.1 0.026 14.3 16.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF966) NUC153 PF08159.12 ETO10414.1 - 1e-12 47.6 1.6 2.5e-12 46.3 1.6 1.7 1 0 0 1 1 1 1 NUC153 domain DUF2316 PF10078.9 ETO10414.1 - 0.0021 18.2 1.6 0.0084 16.3 1.6 2.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) H_PPase PF03030.16 ETO10415.1 - 1.7e-222 740.6 23.5 2.3e-221 736.9 23.4 1.9 1 1 0 1 1 1 1 Inorganic H+ pyrophosphatase DUF1980 PF09323.10 ETO10415.1 - 1.4 8.8 0.0 1.4 8.8 0.0 3.1 4 0 0 4 4 4 0 Domain of unknown function (DUF1980) Wzy_C PF04932.15 ETO10415.1 - 5.7 6.6 9.9 7.5 6.2 0.0 4.5 4 2 1 5 5 5 0 O-Antigen ligase Arm PF00514.23 ETO10416.1 - 1.8e-29 100.8 2.6 1.9e-05 24.5 0.0 6.1 5 1 0 5 5 5 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO10416.1 - 9.1e-09 35.6 0.0 0.0011 19.4 0.1 3.8 3 0 0 3 3 3 2 HEAT-like repeat IBB PF01749.20 ETO10416.1 - 5.3e-06 26.8 10.6 5.3e-06 26.8 10.6 2.1 2 1 0 2 2 2 1 Importin beta binding domain HEAT PF02985.22 ETO10416.1 - 0.0011 19.0 0.0 3.4 8.2 0.0 4.1 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 ETO10416.1 - 0.0026 18.1 0.0 11 6.5 0.0 3.4 2 1 0 3 3 3 1 HEAT repeats PseudoU_synth_1 PF01416.20 ETO10418.1 - 3.4e-24 85.4 0.3 1.9e-17 63.7 0.1 2.5 2 0 0 2 2 2 2 tRNA pseudouridine synthase Acetyltransf_15 PF17013.5 ETO10418.1 - 0.0055 16.2 1.6 0.038 13.4 1.6 2.2 1 1 0 1 1 1 1 Putative acetyl-transferase SUR7 PF06687.12 ETO10419.1 - 0.00019 21.1 2.4 0.00027 20.6 2.4 1.2 1 0 0 1 1 1 1 SUR7/PalI family Tetraspanin PF00335.20 ETO10419.1 - 0.0084 15.8 1.4 0.013 15.2 1.4 1.2 1 0 0 1 1 1 1 Tetraspanin family Phage_holin_3_6 PF07332.11 ETO10419.1 - 0.011 15.8 0.2 0.016 15.2 0.2 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2207 PF09972.9 ETO10419.1 - 0.045 12.5 0.7 0.065 12.0 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Neurensin PF14927.6 ETO10419.1 - 0.085 12.6 0.3 0.19 11.4 0.1 1.6 2 0 0 2 2 2 0 Neurensin TMEM43 PF07787.12 ETO10419.1 - 0.33 10.3 2.8 0.31 10.4 1.4 1.6 2 0 0 2 2 2 0 Transmembrane protein 43 tRNA_anti-codon PF01336.25 ETO10420.1 - 0.00039 20.3 0.1 0.0011 18.9 0.1 1.8 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain EMC3_TMCO1 PF01956.16 ETO10420.1 - 0.019 14.7 0.0 0.031 14.0 0.0 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like VIT1 PF01988.19 ETO10420.1 - 0.12 12.3 2.1 0.28 11.0 1.4 1.9 2 1 0 2 2 2 0 VIT family CENP-N PF05238.13 ETO10420.1 - 0.14 11.5 3.9 0.19 11.0 3.9 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like MAS20 PF02064.15 ETO10420.1 - 1.3 9.1 5.9 2.5 8.2 5.9 1.4 1 0 0 1 1 1 0 MAS20 protein import receptor Herpes_capsid PF06112.11 ETO10421.1 - 0.011 15.9 7.3 0.011 15.9 7.3 3.1 3 0 0 3 3 3 0 Gammaherpesvirus capsid protein BLOC1_2 PF10046.9 ETO10421.1 - 0.018 15.3 4.4 0.018 15.3 4.4 5.8 5 1 1 6 6 6 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-RING_2 PF13639.6 ETO10423.1 - 0.031 14.6 8.0 0.055 13.8 8.0 1.4 1 0 0 1 1 1 0 Ring finger domain FAM176 PF14851.6 ETO10423.1 - 0.048 13.3 13.9 0.76 9.4 0.6 2.2 2 0 0 2 2 2 0 FAM176 family DUF4611 PF15387.6 ETO10423.1 - 0.16 12.2 14.8 0.29 11.4 5.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CDC45 PF02724.14 ETO10423.1 - 1.4 7.1 11.7 1.9 6.7 11.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_60s PF00428.19 ETO10423.1 - 2.1 9.0 13.2 7.2 7.3 0.4 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Pinin_SDK_N PF04697.13 ETO10423.1 - 4.4 7.9 13.1 5.5 7.6 4.8 2.3 1 1 1 2 2 2 0 pinin/SDK conserved region Ku_C PF03730.14 ETO10423.1 - 9.8 7.0 11.9 16 6.3 4.0 2.5 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm RabGAP-TBC PF00566.18 ETO10424.1 - 4.3e-31 108.3 0.3 4.3e-31 108.3 0.3 1.9 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Collagen PF01391.18 ETO10424.1 - 0.036 13.8 0.9 0.079 12.7 0.9 1.5 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) Menin PF05053.13 ETO10425.1 - 1.7 6.9 11.6 2.1 6.6 11.6 1.1 1 0 0 1 1 1 0 Menin DUF5091 PF17012.5 ETO10426.1 - 0.13 12.5 0.0 0.46 10.7 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5091) TFIIA PF03153.13 ETO10427.1 - 0.0048 17.0 10.8 0.0059 16.7 10.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Peptidase_S49_N PF08496.10 ETO10427.1 - 0.0049 16.9 5.1 0.0094 16.0 5.1 1.4 1 0 0 1 1 1 1 Peptidase family S49 N-terminal DUF2722 PF10846.8 ETO10427.1 - 0.044 12.7 10.7 0.067 12.1 10.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) AAA_23 PF13476.6 ETO10427.1 - 0.17 12.4 8.5 0.26 11.8 8.5 1.3 1 0 0 1 1 1 0 AAA domain EIIBC-GUT_N PF03612.14 ETO10427.1 - 0.45 10.2 3.9 0.73 9.5 3.9 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Spt20 PF12090.8 ETO10427.1 - 0.82 9.2 19.8 1.5 8.4 19.8 1.3 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 ETO10427.1 - 1.1 10.3 6.6 2.7 9.0 6.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) WBP-1 PF11669.8 ETO10427.1 - 1.4 9.6 7.9 2.1 9.0 0.5 2.6 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF4175 PF13779.6 ETO10427.1 - 2 6.2 18.2 2.6 5.9 18.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Presenilin PF01080.17 ETO10427.1 - 7 5.3 8.6 0.15 10.8 1.7 1.7 2 0 0 2 2 2 0 Presenilin FAM176 PF14851.6 ETO10428.1 - 0.031 13.9 0.8 0.14 11.8 0.0 2.2 2 0 0 2 2 2 0 FAM176 family Renin_r PF07850.14 ETO10428.1 - 0.2 12.2 0.1 0.2 12.2 0.1 2.9 3 0 0 3 3 3 0 Renin receptor-like protein Ctr PF04145.15 ETO10428.1 - 0.26 11.9 0.0 0.26 11.9 0.0 2.5 3 0 0 3 3 3 0 Ctr copper transporter family Peptidase_S10 PF00450.22 ETO10429.1 - 5.6e-31 108.4 0.1 1.1e-30 107.4 0.1 1.4 1 1 0 1 1 1 1 Serine carboxypeptidase DEAD PF00270.29 ETO10430.1 - 6e-19 68.5 0.0 6.4e-19 68.4 0.0 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase CMS1 PF14617.6 ETO10430.1 - 6.9e-06 25.6 0.0 8.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 ETO10431.1 - 8.5e-15 55.0 0.5 1.1e-14 54.6 0.5 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO10431.1 - 0.00037 20.6 0.9 0.00066 19.7 0.0 1.7 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETO10431.1 - 0.0071 16.1 0.1 0.0094 15.7 0.1 1.2 1 0 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ETO10431.1 - 0.0084 16.0 0.0 0.012 15.4 0.0 1.3 1 0 0 1 1 1 1 Helicase AAA_19 PF13245.6 ETO10431.1 - 0.031 14.6 0.1 0.042 14.2 0.1 1.2 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO10431.1 - 0.061 12.8 0.0 0.092 12.2 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein WD40 PF00400.32 ETO10432.1 - 2.8e-59 195.7 14.1 6.1e-09 36.4 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10432.1 - 1.7e-20 73.1 3.3 0.0029 17.9 0.1 6.1 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO10432.1 - 1.5e-15 57.3 0.1 6.6e-09 35.5 0.0 3.9 1 1 2 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO10432.1 - 1.8e-14 53.4 1.6 0.0081 15.2 0.0 5.8 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO10432.1 - 1e-09 38.6 1.1 0.00081 19.3 0.0 3.4 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO10432.1 - 8.9e-07 28.7 9.8 0.033 14.1 0.0 5.7 5 1 1 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO10432.1 - 3.1e-06 26.0 0.7 0.076 11.5 0.1 3.3 1 1 3 4 4 4 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO10432.1 - 3.3e-06 26.1 5.1 0.033 12.9 0.0 4.4 2 2 1 4 4 4 2 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO10432.1 - 2.5e-05 24.3 0.0 0.44 10.7 0.0 3.2 3 0 0 3 3 3 2 Strictosidine synthase Coatomer_WDAD PF04053.14 ETO10432.1 - 0.0032 16.6 2.0 0.36 9.8 0.1 2.6 1 1 0 2 2 2 2 Coatomer WD associated region ArlS_N PF18719.1 ETO10432.1 - 0.01 16.0 0.2 2.7 8.2 0.0 3.4 3 1 0 3 3 3 0 ArlS sensor domain DUF5359 PF17313.2 ETO10432.1 - 0.023 14.7 0.6 0.042 13.8 0.6 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5359) Me-amine-dh_H PF06433.11 ETO10432.1 - 0.026 13.4 0.0 1.5 7.6 0.0 2.2 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Nbas_N PF15492.6 ETO10432.1 - 0.084 12.2 1.5 3.4 6.9 0.0 3.5 2 1 3 5 5 5 0 Neuroblastoma-amplified sequence, N terminal CorC_HlyC PF03471.17 ETO10432.1 - 0.12 12.4 0.0 1.3 9.1 0.0 2.7 3 0 0 3 3 3 0 Transporter associated domain Syntaxin-6_N PF09177.11 ETO10434.1 - 0.97 10.0 6.8 0.16 12.5 2.9 1.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal CENP-H PF05837.12 ETO10434.1 - 1.3 9.5 8.2 0.3 11.5 4.9 1.5 2 0 0 2 2 2 0 Centromere protein H (CENP-H) ecTbetaR2 PF08917.10 ETO10435.1 - 0.21 11.5 1.0 0.41 10.6 0.0 2.0 2 0 0 2 2 2 0 Transforming growth factor beta receptor 2 ectodomain Pkinase PF00069.25 ETO10436.1 - 7.5e-55 186.1 0.1 6e-54 183.2 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10436.1 - 2.4e-25 89.3 0.0 5.5e-25 88.1 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO10436.1 - 5.8e-06 25.8 0.0 1.3e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO10436.1 - 0.0019 18.2 0.4 0.06 13.2 0.1 2.6 2 1 1 3 3 3 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO10436.1 - 0.014 14.7 0.0 0.027 13.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like PNP_UDP_1 PF01048.20 ETO10437.1 - 1.8e-14 53.6 0.0 2.8e-12 46.4 0.0 2.0 2 0 0 2 2 2 2 Phosphorylase superfamily Pkinase PF00069.25 ETO10438.1 - 1.7e-52 178.4 0.1 2.8e-52 177.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10438.1 - 5.5e-23 81.6 1.6 2.1e-22 79.7 1.6 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO10438.1 - 0.00016 20.6 0.1 0.00032 19.6 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO10438.1 - 0.002 17.2 0.1 0.0035 16.3 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain FTA2 PF13095.6 ETO10438.1 - 0.006 16.2 0.1 0.013 15.1 0.1 1.6 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ETO10438.1 - 0.01 15.2 0.0 0.024 13.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like PIP49_C PF12260.8 ETO10438.1 - 0.011 15.3 0.0 0.025 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 Kdo PF06293.14 ETO10438.1 - 0.013 14.8 0.5 0.031 13.6 0.2 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO10438.1 - 0.03 14.2 0.2 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family RdRP PF05183.12 ETO10439.1 - 4.5e-79 266.6 0.1 1.5e-39 136.1 0.1 2.5 1 1 1 2 2 2 2 RNA dependent RNA polymerase CSG2 PF16965.5 ETO10440.1 - 0.038 13.0 7.5 0.037 13.0 7.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Mem_trans PF03547.18 ETO10440.1 - 0.19 10.1 3.6 0.2 10.0 3.6 1.0 1 0 0 1 1 1 0 Membrane transport protein OATP PF03137.20 ETO10440.1 - 0.29 9.4 1.4 0.31 9.3 1.4 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.19 ETO10440.1 - 0.29 9.0 11.2 0.3 8.9 11.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 ETO10440.1 - 0.33 9.7 18.9 0.38 9.5 18.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ETO10440.1 - 0.45 10.2 5.4 0.51 10.1 5.4 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO10440.1 - 0.62 8.8 14.0 0.72 8.6 14.0 1.0 1 0 0 1 1 1 0 Presenilin Pox_Ag35 PF03286.14 ETO10440.1 - 0.85 9.4 18.2 1.2 8.9 18.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNA_pol_Rpc4 PF05132.14 ETO10440.1 - 0.94 9.9 9.2 1.1 9.6 9.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 GCD14 PF08704.10 ETO10440.1 - 0.96 9.1 9.9 1.2 8.7 9.9 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit MID_MedPIWI PF18296.1 ETO10440.1 - 1.2 8.8 12.4 1.4 8.6 12.4 1.0 1 0 0 1 1 1 0 MID domain of medPIWI Afi1 PF07792.12 ETO10440.1 - 1.6 9.2 18.0 1.8 9.1 18.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 ETO10440.1 - 1.6 6.9 13.4 1.7 6.8 13.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Striatin PF08232.12 ETO10440.1 - 2 9.0 14.5 2.3 8.8 14.5 1.1 1 0 0 1 1 1 0 Striatin family Folliculin PF11704.8 ETO10440.1 - 2.2 8.1 6.3 2.4 8.0 6.3 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport CLN3 PF02487.17 ETO10440.1 - 3.1 6.7 6.8 2.9 6.9 6.8 1.0 1 0 0 1 1 1 0 CLN3 protein NOA36 PF06524.12 ETO10440.1 - 3.6 6.8 18.3 4 6.7 18.3 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO10440.1 - 3.6 8.0 17.7 10 6.6 17.7 1.7 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Zip PF02535.22 ETO10440.1 - 5 6.2 12.9 5.7 6.1 12.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ETO10440.1 - 6 6.8 16.1 7 6.6 16.1 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DUF5308 PF17233.2 ETO10440.1 - 6.4 7.0 6.6 7.3 6.8 6.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Tim54 PF11711.8 ETO10440.1 - 7.5 5.2 14.9 8.8 5.0 14.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 ETO10440.1 - 8 6.6 11.1 12 6.1 11.1 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF1980 PF09323.10 ETO10440.1 - 9.9 6.0 9.0 11 5.9 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PX PF00787.24 ETO10441.1 - 5.4e-17 61.8 2.5 5.4e-17 61.8 2.5 2.6 3 0 0 3 3 3 1 PX domain HJURP_C PF12347.8 ETO10441.1 - 0.00076 19.5 0.4 1.3 9.1 0.2 2.8 2 0 0 2 2 2 2 Holliday junction regulator protein family C-terminal repeat START PF01852.19 ETO10441.1 - 0.0012 18.3 0.0 0.032 13.7 0.0 2.2 2 0 0 2 2 2 1 START domain Ank_2 PF12796.7 ETO10442.1 - 3.7e-08 33.8 0.0 6e-08 33.2 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO10442.1 - 1.2e-06 29.0 0.0 0.00065 20.2 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO10442.1 - 0.00015 21.9 0.0 0.057 14.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO10442.1 - 0.0017 18.6 0.0 0.12 12.7 0.0 2.6 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO10442.1 - 0.085 13.3 0.0 8.5 7.0 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 ETO10443.1 - 1e-09 37.8 0.2 1.7 9.4 0.0 4.4 4 0 0 4 4 4 4 Ankyrin repeat Ank_4 PF13637.6 ETO10443.1 - 4e-09 36.8 0.0 0.0008 19.9 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO10443.1 - 6.2e-09 36.3 0.0 1.8e-06 28.4 0.0 2.6 1 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO10443.1 - 8.3e-06 26.0 0.0 0.079 13.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO10443.1 - 0.0014 19.0 0.0 3 8.4 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Frigida PF07899.11 ETO10444.1 - 0.0071 15.6 0.0 0.14 11.4 0.0 2.1 1 1 1 2 2 2 2 Frigida-like protein Pkinase PF00069.25 ETO10445.1 - 8.8e-46 156.4 4.3 7.6e-17 61.5 0.6 3.8 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10445.1 - 1.5e-18 67.0 8.2 6.4e-07 28.9 0.4 3.8 4 0 0 4 4 4 3 Protein tyrosine kinase ETRAMP PF09716.10 ETO10445.1 - 0.14 12.2 7.4 5.5 7.1 0.2 3.2 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Cpn60_TCP1 PF00118.24 ETO10446.1 - 1.4e-83 281.2 0.1 1.7e-83 280.9 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glutaredoxin2_C PF04399.13 ETO10446.1 - 0.0023 17.8 0.0 0.0071 16.2 0.0 1.8 2 0 0 2 2 2 1 Glutaredoxin 2, C terminal domain Syntaxin-18_N PF10496.9 ETO10447.1 - 0.48 10.7 5.3 0.16 12.3 2.0 1.9 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus HORMA PF02301.18 ETO10448.1 - 8.4e-22 77.8 1.3 1.3e-21 77.2 1.3 1.3 1 0 0 1 1 1 1 HORMA domain Arcadin_1 PF18653.1 ETO10448.1 - 0.0011 19.0 3.4 0.12 12.4 0.2 2.2 1 1 1 2 2 2 2 Arcadin 1 bacHORMA_2 PF18173.1 ETO10448.1 - 0.017 15.0 0.6 0.081 12.8 0.3 1.9 1 1 1 2 2 2 0 Bacterial HORMA domain 2 ATG13 PF10033.9 ETO10448.1 - 0.018 14.7 0.3 0.019 14.7 0.3 1.2 1 0 0 1 1 1 0 Autophagy-related protein 13 Csm1_B PF18211.1 ETO10448.1 - 0.099 12.5 1.3 0.14 12.0 0.2 1.8 2 0 0 2 2 2 0 Csm1 subunit domain B Ala_racemase_N PF01168.20 ETO10448.1 - 0.18 11.4 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain MitMem_reg PF13012.6 ETO10448.1 - 0.19 12.1 1.3 0.94 9.9 1.3 1.9 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function DUF5398 PF17376.2 ETO10448.1 - 0.27 11.9 2.1 24 5.6 0.3 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5398) CNDH2_C PF16858.5 ETO10450.1 - 0.032 14.1 14.5 0.03 14.2 7.7 2.2 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Flu_PB2 PF00604.17 ETO10450.1 - 0.057 11.3 0.0 0.083 10.8 0.0 1.1 1 0 0 1 1 1 0 Influenza RNA-dependent RNA polymerase subunit PB2 DUF2457 PF10446.9 ETO10450.1 - 0.099 11.8 43.7 0.068 12.3 31.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 ETO10450.1 - 0.17 11.2 23.7 0.063 12.6 17.3 2.1 2 0 0 2 2 2 0 BUD22 AAR2 PF05282.11 ETO10450.1 - 0.65 9.3 7.0 0.72 9.2 0.6 2.3 2 0 0 2 2 2 0 AAR2 protein TFIIA PF03153.13 ETO10450.1 - 1.7 8.6 23.4 0.13 12.3 15.4 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 ETO10450.1 - 3.6 6.9 11.2 0.5 9.7 5.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Nop25 PF09805.9 ETO10450.1 - 6 7.3 18.7 4.4 7.8 9.6 2.5 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) FAM60A PF15396.6 ETO10450.1 - 8.7 6.3 13.8 2.1 8.3 5.3 2.3 2 0 0 2 2 2 0 Protein Family FAM60A TFIIF_alpha PF05793.12 ETO10450.1 - 8.8 4.8 26.4 0.11 11.0 14.6 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_18 PF13238.6 ETO10451.1 - 3.5e-25 89.0 3.3 3.8e-23 82.4 0.0 3.6 2 2 0 2 2 2 1 AAA domain AAA_17 PF13207.6 ETO10451.1 - 1.2e-09 38.7 1.5 4.9e-06 27.0 0.0 3.2 3 1 0 3 3 3 2 AAA domain AAA_33 PF13671.6 ETO10451.1 - 1.6e-06 28.3 0.0 0.0035 17.5 0.0 2.6 3 0 0 3 3 3 2 AAA domain AAA PF00004.29 ETO10451.1 - 1.8e-06 28.4 0.3 3.5e-05 24.2 0.0 2.3 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ADK PF00406.22 ETO10451.1 - 0.00014 22.0 0.0 0.025 14.7 0.0 2.3 2 0 0 2 2 2 1 Adenylate kinase NTPase_1 PF03266.15 ETO10451.1 - 0.00019 21.4 0.4 0.0008 19.4 0.0 2.0 2 0 0 2 2 2 1 NTPase RuvB_N PF05496.12 ETO10451.1 - 0.0014 18.4 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_28 PF13521.6 ETO10451.1 - 0.0014 18.9 0.1 0.013 15.7 0.0 2.3 2 1 0 2 2 2 1 AAA domain dNK PF01712.19 ETO10451.1 - 0.0017 18.2 1.2 0.6 9.9 0.0 2.8 3 0 0 3 3 3 1 Deoxynucleoside kinase AAA_16 PF13191.6 ETO10451.1 - 0.0022 18.4 0.0 0.0037 17.7 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO10451.1 - 0.0033 17.8 0.4 0.015 15.7 0.0 2.2 2 0 0 2 2 2 1 RNA helicase ATP_bind_1 PF03029.17 ETO10451.1 - 0.005 16.7 0.2 0.014 15.2 0.0 1.8 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ETO10451.1 - 0.011 16.0 0.9 0.06 13.6 0.1 2.3 2 1 1 3 3 3 0 AAA domain AAA_24 PF13479.6 ETO10451.1 - 0.013 15.2 1.3 0.15 11.8 0.0 2.7 2 1 1 3 3 3 0 AAA domain TsaE PF02367.17 ETO10451.1 - 0.02 14.9 0.2 0.048 13.7 0.0 1.7 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Thymidylate_kin PF02223.17 ETO10451.1 - 0.023 14.4 0.1 6.4 6.4 0.0 2.5 2 1 0 2 2 2 0 Thymidylate kinase AAA_3 PF07726.11 ETO10451.1 - 0.025 14.4 0.0 0.044 13.7 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) FtsK_SpoIIIE PF01580.18 ETO10451.1 - 0.041 13.2 0.2 0.11 11.9 0.0 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family ABC2_membrane_4 PF12730.7 ETO10451.1 - 0.048 13.6 0.0 0.076 13.0 0.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein GTP_EFTU PF00009.27 ETO10451.1 - 0.049 13.2 0.5 0.14 11.7 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain NACHT PF05729.12 ETO10451.1 - 0.054 13.4 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 NACHT domain DUF3808 PF10300.9 ETO10451.1 - 0.058 12.1 0.0 0.084 11.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) Viral_helicase1 PF01443.18 ETO10451.1 - 0.063 13.0 0.2 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DnaB_C PF03796.15 ETO10451.1 - 0.067 12.5 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 DnaB-like helicase C terminal domain ATPase PF06745.13 ETO10451.1 - 0.085 12.2 0.4 0.25 10.7 0.0 1.8 2 0 0 2 2 2 0 KaiC IstB_IS21 PF01695.17 ETO10451.1 - 0.11 12.3 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_19 PF13245.6 ETO10451.1 - 0.12 12.7 0.9 0.53 10.6 0.1 2.2 1 1 1 2 2 2 0 AAA domain Hydin_ADK PF17213.3 ETO10451.1 - 0.15 12.4 0.5 1.9 8.8 0.0 2.1 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain SSL_OB PF09199.10 ETO10451.1 - 0.41 11.0 4.2 14 6.1 0.4 2.6 2 0 0 2 2 2 0 Staphylococcal superantigen-like OB-fold domain AAA_14 PF13173.6 ETO10451.1 - 1.4 9.0 4.0 1.1 9.3 0.4 2.6 2 2 0 2 2 2 0 AAA domain Tetraspanin PF00335.20 ETO10453.1 - 0.051 13.3 0.0 0.12 12.1 0.0 1.9 1 1 0 1 1 1 0 Tetraspanin family Wzy_C PF04932.15 ETO10453.1 - 0.065 12.9 0.0 0.1 12.3 0.0 1.3 1 1 0 1 1 1 0 O-Antigen ligase Plectin PF00681.20 ETO10454.1 - 0.088 12.7 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Plectin repeat Pet100 PF09803.9 ETO10455.1 - 0.019 15.5 1.3 0.59 10.7 0.3 2.6 2 0 0 2 2 2 0 Pet100 S1 PF00575.23 ETO10456.1 - 0.53 10.7 1.9 1 9.7 1.9 1.4 1 0 0 1 1 1 0 S1 RNA binding domain CAF-1_p150 PF11600.8 ETO10456.1 - 0.71 9.6 23.8 1.5 8.5 23.8 1.4 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal Rad10 PF03834.14 ETO10458.1 - 2.9e-05 24.1 0.8 0.00011 22.2 0.8 2.0 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Zip PF02535.22 ETO10458.1 - 0.04 13.1 1.5 0.055 12.7 1.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4611 PF15387.6 ETO10458.1 - 0.44 10.8 3.7 6.1 7.1 0.9 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4611) SelP_N PF04592.14 ETO10458.1 - 1.1 8.6 9.8 1.9 7.8 8.5 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region SPATA9 PF15824.5 ETO10459.1 - 0.069 12.4 0.2 0.1 11.8 0.2 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 9 RGS PF00615.19 ETO10460.1 - 3e-07 30.7 0.1 8.9e-07 29.2 0.1 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain Chromo PF00385.24 ETO10460.1 - 0.037 13.9 0.0 0.12 12.3 0.0 1.8 1 0 0 1 1 1 0 Chromo (CHRromatin Organisation MOdifier) domain Acyl-CoA_dh_N PF02771.16 ETO10461.1 - 2.2e-09 38.0 0.0 2.9e-09 37.6 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain EF-hand_1 PF00036.32 ETO10462.1 - 0.001 18.4 0.2 0.0043 16.5 0.2 2.2 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO10462.1 - 0.0018 18.1 0.3 0.011 15.7 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain Kei1 PF08552.11 ETO10462.1 - 0.0023 17.8 0.2 0.015 15.2 0.2 2.4 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 EF-hand_7 PF13499.6 ETO10462.1 - 0.0086 16.5 0.2 0.0086 16.5 0.2 3.9 4 1 0 4 4 4 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO10462.1 - 0.0094 15.4 0.9 0.031 13.8 0.1 2.4 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO10462.1 - 0.012 15.4 0.5 0.047 13.5 0.1 2.3 2 0 0 2 2 2 0 EF-hand domain pair DUF961 PF06125.11 ETO10462.1 - 1.6 9.2 4.4 0.81 10.1 0.1 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF961) DUF356 PF04009.12 ETO10462.1 - 5.9 7.2 6.6 1.7 8.9 0.2 3.5 4 1 1 5 5 5 0 Protein of unknown function (DUF356) DUF4201 PF13870.6 ETO10463.1 - 0.0076 16.0 1.4 0.0076 16.0 1.4 5.5 2 1 0 4 4 4 3 Domain of unknown function (DUF4201) Mce4_CUP1 PF11887.8 ETO10463.1 - 0.27 10.7 2.1 0.38 10.2 0.2 2.0 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative NPV_P10 PF05531.12 ETO10463.1 - 0.38 11.3 23.5 3.8 8.0 0.4 6.0 4 2 1 5 5 5 0 Nucleopolyhedrovirus P10 protein YtxH PF12732.7 ETO10463.1 - 1.5 9.4 0.0 1.5 9.4 0.0 4.8 2 2 1 3 3 3 0 YtxH-like protein RRN3 PF05327.11 ETO10464.1 - 0.088 11.3 1.9 0.095 11.2 1.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Glypican PF01153.19 ETO10464.1 - 0.38 9.5 4.1 0.47 9.2 4.1 1.1 1 0 0 1 1 1 0 Glypican CDC45 PF02724.14 ETO10464.1 - 0.6 8.3 6.9 0.7 8.1 6.9 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO10464.1 - 3.7 5.5 10.8 4.3 5.3 10.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 ETO10464.1 - 4.8 5.9 8.4 5.8 5.6 8.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3081 PF11280.8 ETO10465.1 - 0.047 13.5 0.0 0.083 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3081) Pkinase PF00069.25 ETO10467.1 - 5.2e-48 163.7 2.8 1.4e-33 116.4 0.0 2.7 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10467.1 - 1.3e-16 60.7 0.1 2.4e-11 43.4 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase cNMP_binding PF00027.29 ETO10467.1 - 1.1e-10 41.4 0.0 1.9e-06 27.9 0.0 2.8 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain SOG2 PF10428.9 ETO10467.1 - 1.9 7.6 23.4 3.5 6.7 23.4 1.4 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 ETO10467.1 - 2.5 6.6 22.4 3.8 6.1 22.4 1.2 1 0 0 1 1 1 0 Hamartin protein Ndc1_Nup PF09531.10 ETO10467.1 - 2.8 6.5 11.3 4.7 5.8 11.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Gly-zipper_Omp PF13488.6 ETO10468.1 - 1.6e-11 44.0 172.4 0.34 10.9 34.2 9.2 1 1 5 6 6 6 5 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO10468.1 - 0.012 15.4 147.9 1.7e+03 -1.1 15.4 9.3 1 1 1 2 2 2 0 YMGG-like Gly-zipper UreD PF01774.17 ETO10469.1 - 0.13 12.2 0.1 0.2 11.5 0.1 1.2 1 0 0 1 1 1 0 UreD urease accessory protein VHL PF01847.16 ETO10470.1 - 2.2e-05 24.3 0.0 5e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 VHL beta domain DUF3855 PF12967.7 ETO10470.1 - 0.027 14.4 0.0 0.37 10.7 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3855) ObR_Ig PF18589.1 ETO10470.1 - 0.045 14.2 0.1 0.64 10.4 0.1 2.4 2 0 0 2 2 2 0 Obesity receptor immunoglobulin like domain OS-D PF03392.13 ETO10470.1 - 0.058 13.5 1.8 0.1 12.7 0.4 2.1 2 0 0 2 2 2 0 Insect pheromone-binding family, A10/OS-D Gal_mutarotas_2 PF13802.6 ETO10470.1 - 0.13 12.6 0.0 3.8 7.9 0.0 2.7 2 0 0 2 2 2 0 Galactose mutarotase-like PRIMA1 PF16101.5 ETO10471.1 - 4.5 7.3 10.7 1.2 9.2 5.8 2.3 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 SpoIIIAH PF12685.7 ETO10471.1 - 7.7 6.3 18.3 1.5 8.6 7.7 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein ASD2 PF08687.11 ETO10471.1 - 9.1 5.7 6.9 26 4.2 0.1 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Tubulin PF00091.25 ETO10472.1 - 3.9e-37 128.4 0.2 7e-37 127.5 0.0 1.4 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ETO10472.1 - 0.0004 20.1 0.0 0.0021 17.8 0.0 1.9 2 0 0 2 2 2 1 Tubulin domain Tubulin_C PF03953.17 ETO10472.1 - 0.0016 18.6 0.3 0.0044 17.2 0.2 1.8 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO10472.1 - 0.0017 17.6 0.5 0.0021 17.3 0.0 1.4 2 0 0 2 2 2 1 Tubulin like T2SSE PF00437.20 ETO10472.1 - 0.13 11.3 0.5 1.1 8.2 0.0 2.0 1 1 1 2 2 2 0 Type II/IV secretion system protein Tubulin_C PF03953.17 ETO10473.1 - 3.9e-28 98.1 0.2 5.4e-28 97.7 0.2 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Vasohibin PF14822.6 ETO10474.1 - 0.02 14.1 0.4 0.022 14.0 0.4 1.1 1 0 0 1 1 1 0 Vasohibin DUF3093 PF11292.8 ETO10476.1 - 0.14 12.4 0.0 0.28 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3093) XK-related PF09815.9 ETO10478.1 - 5.6e-10 38.8 3.1 6.4e-10 38.6 3.1 1.1 1 0 0 1 1 1 1 XK-related protein DUF2632 PF10943.8 ETO10478.1 - 0.3 10.6 8.1 0.36 10.4 7.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2632) Presenilin PF01080.17 ETO10478.1 - 0.6 8.8 5.4 0.72 8.5 5.4 1.1 1 0 0 1 1 1 0 Presenilin IPK PF03770.16 ETO10479.1 - 0.013 15.3 0.2 0.019 14.8 0.2 1.2 1 0 0 1 1 1 0 Inositol polyphosphate kinase Prominin PF05478.11 ETO10479.1 - 4.1 5.3 13.6 0.046 11.7 6.1 1.5 2 0 0 2 2 2 0 Prominin DUF1189 PF06691.11 ETO10480.1 - 0.0039 16.8 0.5 0.0046 16.6 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1189) FF PF01846.19 ETO10481.1 - 3.6e-11 43.1 7.8 2.3e-05 24.5 0.1 3.8 2 1 2 4 4 4 2 FF domain ATP-synt_E PF05680.12 ETO10481.1 - 2.9 8.3 11.8 0.12 12.7 3.4 2.5 3 0 0 3 3 3 0 ATP synthase E chain NACHT PF05729.12 ETO10483.1 - 8.2e-21 74.6 0.0 1.4e-20 73.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO10483.1 - 0.00017 20.8 2.8 0.00018 20.8 0.2 2.3 2 1 1 3 3 3 1 NB-ARC domain AAA_16 PF13191.6 ETO10483.1 - 0.0015 18.9 0.0 0.0049 17.3 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO10483.1 - 0.0024 18.1 2.6 0.012 15.9 0.1 2.9 2 2 0 2 2 2 1 AAA domain Torsin PF06309.11 ETO10483.1 - 0.01 15.9 0.0 0.024 14.7 0.0 1.7 1 0 0 1 1 1 0 Torsin RNA_helicase PF00910.22 ETO10483.1 - 0.012 16.0 0.5 1.5 9.3 0.0 3.6 2 1 1 3 3 3 0 RNA helicase AAA_5 PF07728.14 ETO10483.1 - 0.027 14.5 0.1 0.48 10.4 0.1 2.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) G6PD_C PF02781.16 ETO10484.1 - 2.3e-70 237.1 0.0 3.6e-70 236.5 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ETO10484.1 - 3e-54 184.3 0.4 4.4e-54 183.8 0.4 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF4460 PF14687.6 ETO10484.1 - 0.022 14.8 1.2 0.35 10.9 1.1 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4460) WD40 PF00400.32 ETO10485.1 - 8.5e-39 130.9 23.4 1.8e-06 28.6 0.7 7.1 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO10485.1 - 6.6e-15 54.8 9.5 0.035 12.8 0.0 6.0 1 1 4 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO10485.1 - 2.6e-14 53.3 3.2 0.075 13.3 0.0 6.1 4 1 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO10485.1 - 2.2e-06 27.2 6.6 0.0061 15.9 0.1 4.1 2 2 3 5 5 5 4 WD40-like domain DUF851 PF05867.11 ETO10485.1 - 0.19 11.2 0.0 0.34 10.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF851) Ubiq_cyt_C_chap PF03981.12 ETO10487.1 - 2.5e-08 34.1 0.0 5.1e-08 33.1 0.0 1.6 1 1 0 1 1 1 1 Ubiquinol-cytochrome C chaperone DUF3671 PF12420.8 ETO10487.1 - 0.054 13.6 2.1 0.092 12.8 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function TPR_12 PF13424.6 ETO10488.1 - 1.1e-16 60.9 0.9 2.5e-07 30.9 0.1 3.8 2 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10488.1 - 1.8e-14 52.7 14.3 1.2e-05 25.1 0.3 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10488.1 - 1.5e-13 49.7 8.1 3.7e-05 23.5 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10488.1 - 2.4e-13 49.1 4.8 6.5e-05 22.7 0.1 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10488.1 - 5.8e-12 44.9 18.6 1.4e-05 24.7 0.3 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10488.1 - 2.2e-10 40.1 0.1 0.00013 21.7 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO10488.1 - 3.1e-05 23.9 4.8 0.02 14.9 0.1 3.7 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO10488.1 - 0.00048 19.7 8.1 0.095 12.4 0.2 3.8 3 1 1 4 4 4 3 TPR repeat TPR_17 PF13431.6 ETO10488.1 - 0.0012 19.1 4.3 0.13 12.7 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO10488.1 - 0.0037 17.8 1.2 27 5.7 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO10488.1 - 0.16 12.0 10.6 0.42 10.7 0.4 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF393 PF04134.12 ETO10489.1 - 0.1 14.0 0.3 0.19 13.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF393 LINES_C PF14695.6 ETO10490.1 - 1.1e-13 50.4 1.3 3e-13 48.9 1.3 1.8 1 0 0 1 1 1 1 Lines C-terminus LINES_N PF14694.6 ETO10490.1 - 3.4e-09 36.7 1.4 3.4e-09 36.7 1.4 1.8 2 0 0 2 2 2 1 Lines N-terminus Connexin PF00029.19 ETO10490.1 - 7.4 6.3 17.7 1.7 8.4 1.8 2.9 3 0 0 3 3 3 0 Connexin SID-1_RNA_chan PF13965.6 ETO10491.1 - 0.0036 15.8 3.1 0.0045 15.5 3.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Band_3_cyto PF07565.13 ETO10491.1 - 0.057 13.2 2.3 0.09 12.6 2.3 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF3584 PF12128.8 ETO10491.1 - 0.063 10.8 15.1 0.078 10.5 15.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spt20 PF12090.8 ETO10491.1 - 0.26 10.8 14.0 0.48 10.0 14.0 1.5 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 ETO10491.1 - 5.9 7.5 12.6 16 6.1 12.5 1.8 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ANAPC15 PF15243.6 ETO10492.1 - 1.5 9.3 8.7 1.9 9.0 5.5 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 15 PHC2_SAM_assoc PF16616.5 ETO10493.1 - 9.4 7.1 8.5 19 6.1 8.5 1.5 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Pkinase PF00069.25 ETO10495.1 - 9.2e-10 38.3 0.8 1.1e-09 38.0 0.8 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10495.1 - 0.0059 15.9 0.6 0.0067 15.7 0.6 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Myotub-related PF06602.14 ETO10496.1 - 1.1e-96 323.9 2.6 1.4e-96 323.5 2.6 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 ETO10496.1 - 0.00063 19.4 0.1 0.0011 18.6 0.1 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ETO10496.1 - 0.0031 17.3 0.3 0.0083 15.9 0.3 1.7 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain 3-PAP PF12578.8 ETO10496.1 - 0.005 16.6 0.0 0.009 15.7 0.0 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Y_phosphatase3 PF13350.6 ETO10496.1 - 0.013 15.5 0.1 0.023 14.6 0.1 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family Dynein_heavy PF03028.15 ETO10496.1 - 0.035 14.2 0.3 0.91 9.6 0.0 2.6 3 0 0 3 3 3 0 Dynein heavy chain region D6 P-loop domain YycC PF14174.6 ETO10496.1 - 0.072 12.9 0.7 1.4 8.7 0.1 2.4 2 0 0 2 2 2 0 YycC-like protein Ras PF00071.22 ETO10497.1 - 1.6e-50 170.9 0.1 2.1e-50 170.5 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO10497.1 - 1.7e-27 96.0 0.0 3.9e-27 94.9 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO10497.1 - 2.3e-13 50.0 0.0 3e-13 49.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO10497.1 - 2.2e-05 24.5 0.0 4.6e-05 23.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO10497.1 - 9.8e-05 22.0 0.0 0.00021 20.9 0.0 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain WD40 PF00400.32 ETO10498.1 - 4.4e-41 138.1 28.1 1.8e-06 28.6 0.5 8.0 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10498.1 - 5.3e-14 52.3 0.1 0.014 15.7 0.0 5.3 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10498.1 - 2.3e-11 43.0 7.6 0.098 11.3 0.0 6.0 2 2 3 6 6 6 6 Nucleoporin Nup120/160 Corona_7 PF02398.16 ETO10499.1 - 0.0065 17.0 1.3 0.56 10.8 0.0 2.4 2 0 0 2 2 2 2 Coronavirus protein 7 APOBEC4_like PF18774.1 ETO10499.1 - 0.043 13.7 1.8 0.067 13.1 1.4 1.5 1 1 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Vps53_N PF04100.12 ETO10501.1 - 0.0003 19.9 3.4 0.00089 18.3 3.3 1.7 1 1 0 1 1 1 1 Vps53-like, N-terminal PH_2 PF08458.10 ETO10501.1 - 0.0022 18.3 0.3 0.0071 16.7 0.3 1.9 1 0 0 1 1 1 1 Plant pleckstrin homology-like region NST1 PF13945.6 ETO10501.1 - 0.37 10.9 10.7 0.72 9.9 10.7 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Vps62 PF06101.11 ETO10502.1 - 1.9e-06 26.5 0.0 0.032 12.6 0.0 2.5 3 0 0 3 3 3 2 Vacuolar protein sorting-associated protein 62 RXT2_N PF08595.11 ETO10503.1 - 0.062 13.3 7.8 0.11 12.5 7.8 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 ETO10503.1 - 0.092 12.1 11.4 0.13 11.6 11.4 1.1 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 ETO10503.1 - 0.34 10.1 3.3 0.41 9.8 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 ETO10503.1 - 0.44 9.5 4.5 0.56 9.1 4.5 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2076 PF09849.9 ETO10503.1 - 0.9 9.5 9.2 1.3 9.0 9.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Herpes_LMP1 PF05297.11 ETO10503.1 - 4.4 6.4 5.0 5.1 6.2 5.0 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) FAM176 PF14851.6 ETO10503.1 - 7 6.3 8.5 19 4.9 8.4 1.9 1 1 0 1 1 1 0 FAM176 family 2OG-FeII_Oxy_3 PF13640.6 ETO10504.1 - 3.3e-17 63.2 0.2 6.9e-17 62.1 0.2 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 ETO10504.1 - 0.006 17.2 0.1 0.015 16.0 0.1 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3572 PF12096.8 ETO10506.1 - 0.17 12.1 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3572) ThiP_synth PF10120.9 ETO10507.1 - 0.053 13.1 0.0 0.084 12.5 0.0 1.2 1 0 0 1 1 1 0 Thiamine-phosphate synthase PI3_PI4_kinase PF00454.27 ETO10508.1 - 2.3e-27 96.4 2.1 1.3e-13 51.4 0.0 2.4 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase Rep_fac_C PF08542.11 ETO10509.1 - 8.2e-09 35.8 0.1 1.5e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 Replication factor C C-terminal domain AAA_assoc_2 PF16193.5 ETO10509.1 - 0.0042 17.4 0.0 0.0077 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA C-terminal domain DNA_pol3_delta2 PF13177.6 ETO10509.1 - 0.017 14.9 0.1 0.095 12.5 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase III, delta subunit WD40 PF00400.32 ETO10510.1 - 3.7e-08 33.9 8.2 0.00019 22.1 0.1 5.7 6 1 0 6 6 6 2 WD domain, G-beta repeat PD40 PF07676.12 ETO10510.1 - 5.1e-06 26.3 1.7 4.5 7.3 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat ANAPC4_WD40 PF12894.7 ETO10510.1 - 1.1e-05 25.6 0.0 3 8.2 0.0 4.8 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO10510.1 - 0.00037 20.4 4.5 0.75 9.7 0.0 3.6 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO10510.1 - 0.028 13.7 0.0 14 4.9 0.0 3.1 2 1 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal F-box-like PF12937.7 ETO10511.1 - 6.1e-06 26.0 0.1 1.1e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO10511.1 - 0.00012 21.8 0.2 0.00022 21.0 0.2 1.4 1 0 0 1 1 1 1 F-box domain F-box_4 PF15966.5 ETO10511.1 - 0.01 15.7 0.3 0.019 14.8 0.1 1.5 2 0 0 2 2 2 0 F-box DUF3232 PF11554.8 ETO10511.1 - 0.01 16.2 0.1 0.014 15.7 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3232) CCDC106 PF15794.5 ETO10513.1 - 0.028 14.2 9.9 0.04 13.6 9.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Presenilin PF01080.17 ETO10513.1 - 0.96 8.1 4.3 1.1 7.9 4.3 1.2 1 0 0 1 1 1 0 Presenilin FAP PF07174.11 ETO10513.1 - 3.5 7.0 10.6 5 6.5 10.6 1.2 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) zf-C2H2 PF00096.26 ETO10514.1 - 2.6e-11 43.3 20.7 0.00089 19.6 0.8 4.0 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO10514.1 - 0.00023 21.7 22.5 0.24 12.3 0.7 4.5 3 1 0 3 3 3 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO10514.1 - 0.2 12.1 16.4 0.4 11.2 0.9 4.4 4 0 0 4 4 4 0 Zinc-finger double domain PHD PF00628.29 ETO10514.1 - 0.81 9.6 11.7 0.13 12.1 6.8 2.2 2 0 0 2 2 2 0 PHD-finger C1_4 PF07975.12 ETO10514.1 - 1.1 9.6 13.0 1.4 9.2 3.9 3.5 1 1 2 3 3 3 0 TFIIH C1-like domain zf-BED PF02892.15 ETO10514.1 - 6.4 6.9 15.9 13 5.9 0.4 3.9 1 1 2 3 3 3 0 BED zinc finger GATase PF00117.28 ETO10515.1 - 4.5e-34 117.9 0.0 9.3e-34 116.9 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase class-I GMP_synt_C PF00958.22 ETO10515.1 - 2.3e-11 43.6 0.0 7.4e-10 38.8 0.0 2.6 2 0 0 2 2 2 1 GMP synthase C terminal domain Peptidase_C26 PF07722.13 ETO10515.1 - 1.7e-08 34.5 0.1 1.5e-06 28.1 0.1 2.8 2 1 0 2 2 2 1 Peptidase C26 Asn_synthase PF00733.21 ETO10515.1 - 1.7e-05 24.6 0.0 3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Asparagine synthase NAD_synthase PF02540.17 ETO10515.1 - 5.2e-05 22.5 0.0 0.018 14.2 0.0 2.6 2 0 0 2 2 2 2 NAD synthase tRNA_Me_trans PF03054.16 ETO10515.1 - 0.00021 20.2 0.1 0.00081 18.3 0.1 1.8 2 0 0 2 2 2 1 tRNA methyl transferase QueC PF06508.13 ETO10515.1 - 0.005 16.4 1.1 1.3 8.5 1.1 3.3 2 1 0 2 2 2 1 Queuosine biosynthesis protein QueC GATase_3 PF07685.14 ETO10515.1 - 0.0088 15.7 0.0 0.019 14.5 0.0 1.5 1 0 0 1 1 1 1 CobB/CobQ-like glutamine amidotransferase domain ThiI PF02568.14 ETO10515.1 - 0.015 14.9 0.2 0.16 11.5 0.0 2.3 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) PAPS_reduct PF01507.19 ETO10515.1 - 0.041 13.9 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Phosphoadenosine phosphosulfate reductase family Ketoacyl-synt_C PF02801.22 ETO10515.1 - 0.066 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, C-terminal domain DUF16 PF01519.16 ETO10515.1 - 0.73 10.4 8.7 1.6 9.2 8.7 1.6 1 0 0 1 1 1 0 Protein of unknown function DUF16 RRP36 PF06102.12 ETO10515.1 - 1.8 8.5 4.8 3.9 7.4 4.8 1.6 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 TMPIT PF07851.13 ETO10515.1 - 5.2 6.2 7.5 9.8 5.3 7.5 1.4 1 0 0 1 1 1 0 TMPIT-like protein RNA_pol_Rpb1_5 PF04998.17 ETO10515.1 - 8.7 5.7 6.8 3 7.2 0.2 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 5 Prp18 PF02840.15 ETO10516.1 - 4.9e-50 169.3 0.1 4.9e-50 169.3 0.1 2.5 3 0 0 3 3 3 1 Prp18 domain PRP4 PF08799.11 ETO10516.1 - 4.2e-11 42.2 6.2 4.2e-11 42.2 6.2 2.1 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like B5 PF03484.15 ETO10516.1 - 2.7 8.3 7.1 7.9 6.9 7.1 1.8 1 1 0 1 1 1 0 tRNA synthetase B5 domain Pro_isomerase PF00160.21 ETO10517.1 - 6.5e-49 166.2 0.1 2e-48 164.7 0.1 1.9 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD DUF2894 PF11445.8 ETO10517.1 - 9.4 6.7 9.8 1.5 9.3 5.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2894) BRCT PF00533.26 ETO10519.1 - 0.026 14.9 0.4 0.21 12.0 0.0 2.4 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain WD40 PF00400.32 ETO10520.1 - 3e-35 119.6 26.6 3.7e-06 27.6 0.3 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10520.1 - 2.5e-13 50.2 3.0 0.0026 18.0 0.0 5.9 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10520.1 - 1.4e-06 27.2 9.7 0.36 9.4 0.0 5.1 2 2 3 5 5 5 5 Nucleoporin Nup120/160 DUF4867 PF16161.5 ETO10520.1 - 0.067 12.6 0.1 4.7 6.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4867) Nucleoporin_N PF08801.11 ETO10520.1 - 0.36 9.5 7.0 0.58 8.8 0.7 3.1 1 1 0 2 2 2 0 Nup133 N terminal like WD40 PF00400.32 ETO10521.1 - 1.6e-42 142.7 19.8 3.1e-08 34.1 0.1 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10521.1 - 5.5e-12 45.8 0.6 0.043 14.1 0.0 5.7 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10521.1 - 1.9e-08 33.5 8.3 0.066 11.8 1.3 5.4 1 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO10521.1 - 7.5e-05 22.2 3.1 0.34 10.2 0.1 4.1 2 2 1 3 3 3 3 WD40-like domain ECF_trnsprt PF12822.7 ETO10522.1 - 0.036 14.1 4.3 0.062 13.4 4.2 1.4 1 1 0 1 1 1 0 ECF transporter, substrate-specific component Gram_pos_anchor PF00746.21 ETO10522.1 - 0.092 12.7 0.4 0.21 11.5 0.4 1.6 1 0 0 1 1 1 0 LPXTG cell wall anchor motif PDEase_I PF00233.19 ETO10523.1 - 8.9e-30 104.2 0.5 8.9e-30 104.2 0.5 2.5 2 2 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase PACT_coil_coil PF10495.9 ETO10523.1 - 0.084 13.5 2.2 0.22 12.1 1.1 2.3 3 0 0 3 3 3 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein Myotub-related PF06602.14 ETO10524.1 - 3.5e-136 453.8 1.6 4.5e-136 453.4 1.6 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 ETO10524.1 - 0.0071 15.9 0.4 0.016 14.8 0.1 1.7 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 ETO10524.1 - 0.018 14.8 0.1 0.05 13.4 0.1 1.7 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO10524.1 - 0.049 13.6 0.0 0.091 12.7 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family HTH_29 PF13551.6 ETO10524.1 - 0.11 12.6 0.0 0.23 11.5 0.0 1.5 1 0 0 1 1 1 0 Winged helix-turn helix UPF0257 PF06788.13 ETO10526.1 - 0.067 13.0 0.1 0.069 13.0 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0257) CAP_GLY PF01302.25 ETO10527.1 - 7.7e-06 25.8 0.2 2.2e-05 24.4 0.1 1.9 2 1 0 2 2 2 1 CAP-Gly domain EF-hand_1 PF00036.32 ETO10527.1 - 0.015 14.8 0.2 0.032 13.8 0.2 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 ETO10527.1 - 0.057 13.4 0.6 0.13 12.2 0.6 1.6 1 0 0 1 1 1 0 EF-hand domain AI-2E_transport PF01594.16 ETO10528.1 - 0.15 11.2 0.5 0.43 9.7 0.2 1.9 2 0 0 2 2 2 0 AI-2E family transporter DUF1235 PF06822.12 ETO10529.1 - 0.024 14.0 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1235) Nop14 PF04147.12 ETO10530.1 - 0.015 13.6 7.0 0.017 13.4 7.0 1.1 1 0 0 1 1 1 0 Nop14-like family DUF4820 PF16091.5 ETO10530.1 - 1.1 8.6 7.1 1.7 8.0 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DSBA PF01323.20 ETO10531.1 - 2.2e-19 70.0 0.0 4.9e-16 59.1 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ETO10531.1 - 0.12 12.5 0.0 0.32 11.1 0.0 1.7 2 0 0 2 2 2 0 Thioredoxin NOA36 PF06524.12 ETO10532.1 - 1.3 8.3 9.6 1.6 7.9 9.6 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2076 PF09849.9 ETO10532.1 - 2.3 8.2 9.5 3.1 7.8 9.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Herpes_LMP1 PF05297.11 ETO10532.1 - 2.8 7.0 6.9 3.2 6.9 6.9 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Caudo_TAP PF02413.17 ETO10533.1 - 0.092 12.9 3.4 0.12 12.5 3.4 1.1 1 0 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Cupin_4 PF08007.12 ETO10533.1 - 0.16 11.4 0.8 0.18 11.3 0.8 1.0 1 0 0 1 1 1 0 Cupin superfamily protein RAC_head PF16717.5 ETO10533.1 - 3.2 8.8 15.8 0.22 12.5 5.8 2.4 2 0 0 2 2 2 0 Ribosome-associated complex head domain Pex24p PF06398.11 ETO10534.1 - 0.0039 16.2 5.6 0.46 9.4 3.3 2.8 1 1 1 2 2 2 2 Integral peroxisomal membrane peroxin Kelch_2 PF07646.15 ETO10536.1 - 3.9e-06 26.6 5.0 0.038 14.0 0.1 4.7 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ETO10536.1 - 0.0014 18.6 3.9 1.3 9.0 0.0 4.4 5 0 0 5 5 5 2 Kelch motif N_Asn_amidohyd PF14736.6 ETO10536.1 - 0.056 12.6 0.1 2.6 7.1 0.0 2.3 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_3 PF13415.6 ETO10536.1 - 0.14 12.5 0.3 5.1 7.5 0.0 3.5 5 0 0 5 5 5 0 Galactose oxidase, central domain TMIE PF16038.5 ETO10538.1 - 0.34 10.8 1.6 0.7 9.8 1.6 1.5 1 0 0 1 1 1 0 TMIE protein Tim54 PF11711.8 ETO10539.1 - 0.036 12.9 4.1 0.065 12.0 4.1 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 IL4Ra_N PF09238.10 ETO10539.1 - 0.044 14.1 0.0 0.092 13.1 0.0 1.5 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal UPF0560 PF10577.9 ETO10539.1 - 0.13 10.7 5.4 0.2 10.1 5.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RMI1_N PF08585.12 ETO10539.1 - 0.27 11.0 4.1 0.4 10.4 4.1 1.3 1 0 0 1 1 1 0 RecQ mediated genome instability protein Dsh_C PF12316.8 ETO10539.1 - 0.99 9.8 8.3 3 8.2 8.3 1.7 1 1 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal SOG2 PF10428.9 ETO10539.1 - 1.9 7.6 8.6 2.5 7.2 8.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Pex14_N PF04695.13 ETO10539.1 - 2.2 8.9 8.2 0.23 12.1 3.8 1.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 ETO10539.1 - 2.8 6.6 10.6 5.9 5.6 10.6 1.6 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO10540.1 - 2.9e-14 53.2 10.1 2.5e-05 24.9 0.2 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10540.1 - 0.023 15.0 0.2 12 6.3 0.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10540.1 - 0.044 12.4 0.2 7.2 5.1 0.0 2.4 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Ig_6 PF18452.1 ETO10540.1 - 0.094 12.3 1.2 0.45 10.1 0.1 2.2 2 0 0 2 2 2 0 Immunoglobulin domain WD40 PF00400.32 ETO10541.1 - 0.0092 16.8 0.2 0.065 14.1 0.4 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat SWIRM-assoc_2 PF16496.5 ETO10542.1 - 2.8e-17 62.7 2.7 3.1e-17 62.6 2.7 1.1 1 0 0 1 1 1 1 SWIRM-associated domain at the N-terminal DUF4720 PF15846.5 ETO10543.1 - 0.071 12.9 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4720) DUF3464 PF11947.8 ETO10544.1 - 0.0037 17.0 0.0 0.0046 16.7 0.0 1.1 1 0 0 1 1 1 1 Photosynthesis affected mutant 68 FTHFS PF01268.19 ETO10544.1 - 0.11 10.7 0.4 0.15 10.2 0.2 1.2 1 1 0 1 1 1 0 Formate--tetrahydrofolate ligase Sua5_yciO_yrdC PF01300.18 ETO10545.1 - 0.072 12.6 0.1 0.13 11.7 0.1 1.4 1 0 0 1 1 1 0 Telomere recombination ISK_Channel PF02060.15 ETO10545.1 - 1.7 8.3 7.7 2.1 8.0 4.5 2.6 2 1 0 2 2 2 0 Slow voltage-gated potassium channel zf-CCHH PF10283.9 ETO10546.1 - 7.3e-12 45.0 1.3 1.6e-11 43.9 1.3 1.6 1 0 0 1 1 1 1 PBZ domain DUF1298 PF06974.13 ETO10547.1 - 1.1e-12 48.1 0.0 1.6e-12 47.6 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1298) Gar1 PF04410.14 ETO10549.1 - 1e-11 44.8 1.9 2.3e-11 43.7 0.7 2.2 1 1 1 2 2 2 1 Gar1/Naf1 RNA binding region ALMT PF11744.8 ETO10549.1 - 0.059 12.2 1.1 0.084 11.7 1.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter LemA PF04011.12 ETO10550.1 - 0.042 13.7 1.0 0.093 12.6 0.2 2.0 2 1 0 2 2 2 0 LemA family Saf_2TM PF18303.1 ETO10550.1 - 0.049 13.2 0.0 0.1 12.2 0.0 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Mononeg_mRNAcap PF14318.6 ETO10551.1 - 0.042 13.1 0.4 0.066 12.5 0.4 1.4 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V ATP-synt PF00231.19 ETO10552.1 - 7.6e-08 32.4 0.7 8.9e-08 32.2 0.7 1.1 1 0 0 1 1 1 1 ATP synthase DuffyBP_N PF12377.8 ETO10552.1 - 0.04 14.3 0.0 0.06 13.7 0.0 1.2 1 0 0 1 1 1 0 Duffy binding protein N terminal ATP-synt PF00231.19 ETO10553.1 - 1.2e-08 35.1 0.0 1.5e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 ATP synthase DUF3915 PF13054.6 ETO10553.1 - 0.037 14.0 0.5 4.2 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) TPR_12 PF13424.6 ETO10554.1 - 1.8e-77 255.6 6.4 4.5e-17 62.1 0.3 5.5 3 2 3 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10554.1 - 5.7e-42 139.9 26.4 3e-07 30.0 0.6 8.2 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10554.1 - 1.9e-40 135.6 6.6 1.7e-08 34.1 0.0 8.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10554.1 - 4.1e-38 126.4 26.6 2.5e-06 27.3 0.2 7.4 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10554.1 - 1.2e-37 124.9 15.9 4.2e-06 26.4 0.6 7.5 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10554.1 - 1.7e-34 115.3 5.4 0.0001 22.0 0.1 7.6 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO10554.1 - 1.8e-20 73.3 0.0 0.00018 22.1 0.0 6.8 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10554.1 - 3.8e-18 64.9 27.3 0.0001 21.9 5.8 8.1 7 2 2 9 9 8 4 TPR repeat TPR_17 PF13431.6 ETO10554.1 - 3.2e-15 55.3 1.8 0.03 14.7 0.1 7.6 6 1 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO10554.1 - 2.5e-14 52.7 0.0 0.27 12.1 0.0 7.3 7 1 1 8 8 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO10554.1 - 6.1e-13 48.5 0.2 0.59 10.9 0.0 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat SNAP PF14938.6 ETO10554.1 - 9e-12 45.0 0.3 0.00079 18.9 0.0 3.2 3 0 0 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 ETO10554.1 - 5.4e-08 33.2 0.1 0.015 15.8 0.0 4.4 4 1 1 5 5 5 2 Tetratricopeptide repeat MIT PF04212.18 ETO10554.1 - 5.8e-08 32.7 19.2 0.035 14.2 0.6 6.3 7 0 0 7 7 6 3 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO10554.1 - 8.3e-08 32.2 8.4 0.44 10.3 0.1 5.1 5 1 0 5 5 5 4 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETO10554.1 - 5.2e-06 26.3 6.9 0.8 9.4 0.0 5.7 3 2 2 5 5 5 1 26S proteasome subunit RPN7 DUF2225 PF09986.9 ETO10554.1 - 3e-05 23.9 5.3 0.075 12.7 0.5 3.8 1 1 3 4 4 4 2 Uncharacterized protein conserved in bacteria (DUF2225) SHNi-TPR PF10516.9 ETO10554.1 - 3.4e-05 23.2 0.5 5.5 6.5 0.1 5.5 5 0 0 5 5 5 1 SHNi-TPR TPR_3 PF07720.12 ETO10554.1 - 9.6e-05 22.3 10.4 1.8 8.6 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO10554.1 - 0.00029 20.3 0.0 0.37 10.1 0.0 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_21 PF09976.9 ETO10554.1 - 0.00068 19.4 7.8 0.35 10.6 0.0 4.4 3 2 1 5 5 5 2 Tetratricopeptide repeat-like domain PPR PF01535.20 ETO10554.1 - 0.00079 19.5 7.2 1.8 9.0 0.0 6.2 7 0 0 7 7 6 1 PPR repeat DUF627 PF04781.12 ETO10554.1 - 0.0038 17.2 0.7 5.1 7.1 0.0 4.4 4 2 1 5 5 5 1 Protein of unknown function (DUF627) DUF4810 PF16068.5 ETO10554.1 - 0.024 15.2 3.9 1.9 9.1 0.3 4.3 4 1 1 5 5 5 0 Domain of unknown function (DUF4810) Sel1 PF08238.12 ETO10554.1 - 0.041 14.6 8.3 20 6.0 0.0 5.6 6 1 0 6 6 5 0 Sel1 repeat Vps39_1 PF10366.9 ETO10554.1 - 0.044 14.1 1.4 0.6 10.4 0.1 3.0 2 2 1 3 3 2 0 Vacuolar sorting protein 39 domain 1 ANAPC3 PF12895.7 ETO10554.1 - 0.053 13.8 7.4 1.2 9.4 0.3 4.3 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TOM20_plant PF06552.12 ETO10554.1 - 0.12 12.1 4.6 9.8 5.9 0.0 4.4 3 1 1 5 5 5 0 Plant specific mitochondrial import receptor subunit TOM20 BTAD PF03704.17 ETO10554.1 - 0.12 12.8 0.1 5.1 7.5 0.1 3.2 3 1 0 3 3 2 0 Bacterial transcriptional activator domain TetR_C_19 PF17924.1 ETO10554.1 - 0.12 12.9 5.5 4.9 7.8 0.1 4.4 5 1 1 6 6 4 0 Tetracyclin repressor-like, C-terminal domain HnRNPA1 PF11627.8 ETO10554.1 - 8.7 6.6 6.6 11 6.4 0.5 3.0 3 0 0 3 3 3 0 Nuclear factor hnRNPA1 Hydrolase_4 PF12146.8 ETO10555.1 - 3.2e-07 29.9 0.0 1.3e-06 27.9 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO10555.1 - 3.8e-05 24.4 0.0 5.7e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETO10555.1 - 6.8e-05 22.6 0.0 0.00035 20.3 0.0 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold VanY PF02557.17 ETO10555.1 - 0.055 13.3 0.2 0.12 12.2 0.2 1.5 1 0 0 1 1 1 0 D-alanyl-D-alanine carboxypeptidase adh_short_C2 PF13561.6 ETO10556.1 - 1.6e-38 132.6 0.0 8.5e-27 94.2 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO10556.1 - 1e-24 87.1 0.4 3.2e-11 43.1 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase AKNA PF12443.8 ETO10558.1 - 0.034 14.8 3.3 0.043 14.5 3.3 1.3 1 0 0 1 1 1 0 AT-hook-containing transcription factor DUF412 PF04217.13 ETO10558.1 - 0.068 13.1 0.7 0.077 12.9 0.7 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF412 DUF1664 PF07889.12 ETO10558.1 - 0.084 12.9 2.3 0.13 12.3 2.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) tRNA_int_end_N2 PF12928.7 ETO10559.1 - 0.00093 19.3 0.0 0.003 17.7 0.0 1.9 2 0 0 2 2 2 1 tRNA-splicing endonuclease subunit sen54 N-term WD40 PF00400.32 ETO10560.1 - 3e-06 27.9 7.4 0.0069 17.2 0.1 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Pyridox_ox_2 PF12900.7 ETO10561.1 - 3.1e-14 53.2 0.0 8e-13 48.6 0.0 2.2 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase ATG27 PF09451.10 ETO10561.1 - 0.012 15.4 0.1 0.018 14.9 0.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 27 CDC45 PF02724.14 ETO10562.1 - 0.019 13.3 32.3 0.15 10.3 0.6 2.3 2 0 0 2 2 2 0 CDC45-like protein Hrs_helical PF12210.8 ETO10562.1 - 0.06 13.9 4.2 0.18 12.3 4.2 1.8 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Baculo_PEP_C PF04513.12 ETO10562.1 - 0.063 13.3 1.2 0.13 12.3 1.2 1.5 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus ACCA PF03255.14 ETO10562.1 - 0.1 12.4 2.6 0.39 10.6 2.6 2.1 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit BSP_II PF05432.11 ETO10562.1 - 0.67 9.6 23.0 1.4 8.5 23.0 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) BUD22 PF09073.10 ETO10562.1 - 1.6 8.0 40.8 0.017 14.5 26.4 2.6 2 1 0 3 3 3 0 BUD22 NPV_P10 PF05531.12 ETO10562.1 - 1.8 9.1 7.0 14 6.2 3.5 2.7 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Occludin_ELL PF07303.13 ETO10562.1 - 3.2 8.5 14.4 0.66 10.7 5.9 3.1 2 1 1 3 3 3 0 Occludin homology domain CLZ PF16526.5 ETO10562.1 - 10 6.6 10.6 9.5 6.7 1.1 3.5 2 1 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels fn3 PF00041.21 ETO10563.1 - 0.15 12.4 0.0 0.39 11.1 0.0 1.7 2 0 0 2 2 2 0 Fibronectin type III domain TLD PF07534.16 ETO10564.1 - 5.9e-10 39.5 1.3 1e-09 38.7 1.3 1.4 1 1 0 1 1 1 1 TLD SMN PF06003.12 ETO10564.1 - 0.017 14.4 0.8 0.025 13.8 0.8 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) PEP_mutase PF13714.6 ETO10565.1 - 3.1e-65 220.0 0.0 4e-65 219.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase L27 PF02828.16 ETO10565.1 - 0.04 13.7 0.0 0.086 12.6 0.0 1.5 1 0 0 1 1 1 0 L27 domain Ala_racemase_N PF01168.20 ETO10566.1 - 4e-06 26.6 0.0 6e-06 26.1 0.0 1.2 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain N_BRCA1_IG PF16158.5 ETO10567.1 - 5.8e-14 52.7 0.0 1.7e-13 51.2 0.0 1.8 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 ETO10567.1 - 1e-13 50.8 17.5 1.3e-12 47.3 3.8 2.7 2 1 0 2 2 2 2 Zinc finger, ZZ type Serinc PF03348.15 ETO10567.1 - 4 6.2 5.2 10 4.9 5.2 1.7 1 0 0 1 1 1 0 Serine incorporator (Serinc) Hid1 PF12722.7 ETO10567.1 - 6.9 4.7 18.2 0.14 10.3 7.3 2.1 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein Glyco_hydro_49N PF17433.2 ETO10568.1 - 0.024 14.3 0.6 0.031 13.9 0.6 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 49 N-terminal Ig-like domain MIF4G PF02854.19 ETO10569.1 - 6e-22 78.3 2.2 8.3e-20 71.3 2.2 2.1 1 1 0 1 1 1 1 MIF4G domain WD40 PF00400.32 ETO10570.1 - 1.7e-07 31.8 5.2 5.1e-05 24.0 1.0 3.4 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO10570.1 - 0.0026 16.5 0.2 0.96 8.0 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO10571.1 - 2.4e-18 66.1 6.1 5.9e-07 30.1 0.4 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10571.1 - 5e-05 23.5 0.4 2.3 8.6 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10571.1 - 0.00018 20.3 2.3 0.22 10.1 1.2 2.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO10571.1 - 0.0026 17.1 2.8 1.1 8.6 0.3 2.6 1 1 1 2 2 2 2 WD40-like domain SOG2 PF10428.9 ETO10572.1 - 0.0036 16.6 13.1 0.004 16.4 13.1 1.0 1 0 0 1 1 1 1 RAM signalling pathway protein Mucin PF01456.17 ETO10572.1 - 0.025 14.6 12.9 0.036 14.1 12.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein TFIIA PF03153.13 ETO10572.1 - 0.042 13.9 16.4 0.046 13.7 16.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MAP65_ASE1 PF03999.12 ETO10572.1 - 0.052 12.2 16.0 0.059 12.1 16.0 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Macoilin PF09726.9 ETO10572.1 - 0.084 11.4 7.5 0.098 11.2 7.5 1.1 1 0 0 1 1 1 0 Macoilin family PAP1 PF08601.10 ETO10572.1 - 0.11 12.2 14.2 0.12 12.1 14.2 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Ndc1_Nup PF09531.10 ETO10572.1 - 0.13 10.9 7.6 0.14 10.8 7.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF4058 PF13267.6 ETO10572.1 - 0.19 11.1 2.0 0.23 10.9 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4058) Apt1 PF10351.9 ETO10572.1 - 0.5 9.2 8.3 0.55 9.0 8.3 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain MtrE PF04206.12 ETO10572.1 - 0.85 8.9 4.9 1.2 8.4 4.9 1.3 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, subunit E FAM220 PF15487.6 ETO10572.1 - 1.1 8.8 10.4 1.4 8.4 10.4 1.2 1 0 0 1 1 1 0 FAM220 family ALMT PF11744.8 ETO10572.1 - 2 7.2 9.0 2.1 7.1 9.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter SR-25 PF10500.9 ETO10572.1 - 5.5 6.5 18.6 7.1 6.2 18.6 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein GREB1 PF15782.5 ETO10572.1 - 5.8 3.9 20.1 6.6 3.7 20.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NST1 PF13945.6 ETO10572.1 - 7.4 6.6 11.5 9.2 6.3 11.5 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Aa_trans PF01490.18 ETO10574.1 - 3.2e-18 65.7 9.2 3.4e-18 65.6 9.2 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CDC45 PF02724.14 ETO10575.1 - 0.16 10.3 19.9 0.21 9.8 19.9 1.2 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO10575.1 - 1 7.7 12.2 1.1 7.5 12.2 1.2 1 0 0 1 1 1 0 Menin LAP1C PF05609.12 ETO10575.1 - 4.1 6.4 22.2 5.1 6.1 22.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 ETO10575.1 - 6.9 3.6 17.8 8.4 3.4 17.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Terminase_6 PF03237.15 ETO10576.1 - 0.024 14.3 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Terminase-like family RNase_H PF00075.24 ETO10577.1 - 2.1e-08 34.5 0.0 2.4e-08 34.3 0.0 1.0 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETO10577.1 - 0.014 15.2 0.0 0.017 15.0 0.0 1.1 1 0 0 1 1 1 0 Reverse transcriptase-like Fer4_24 PF18109.1 ETO10577.1 - 0.067 13.5 0.0 0.18 12.1 0.0 1.8 1 1 0 1 1 1 0 Ferredoxin I 4Fe-4S cluster domain SAP PF02037.27 ETO10578.1 - 7.5e-09 35.1 0.0 7.5e-09 35.1 0.0 2.5 3 0 0 3 3 3 1 SAP domain SAP30_Sin3_bdg PF13867.6 ETO10578.1 - 0.014 15.7 0.1 0.035 14.4 0.1 1.7 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF1688 PF07958.11 ETO10579.1 - 1.6e-144 481.8 0.0 1.8e-144 481.6 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1688) Q_salvage PF10343.9 ETO10579.1 - 4.2e-05 23.3 0.0 0.00048 19.8 0.0 2.1 2 0 0 2 2 2 1 Potential Queuosine, Q, salvage protein family Barstar PF01337.18 ETO10579.1 - 0.007 16.4 0.0 0.23 11.5 0.0 2.5 2 0 0 2 2 2 1 Barstar (barnase inhibitor) Erythro_esteras PF05139.14 ETO10579.1 - 0.18 11.6 0.0 0.27 11.0 0.0 1.2 1 0 0 1 1 1 0 Erythromycin esterase BCAS2 PF05700.11 ETO10580.1 - 0.096 12.4 0.2 0.12 12.0 0.2 1.1 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) zf-RING-like PF08746.11 ETO10581.1 - 0.043 14.1 3.0 0.052 13.9 0.1 2.4 2 0 0 2 2 2 0 RING-like domain VHP PF02209.19 ETO10584.1 - 3e-16 59.2 9.2 3.2e-15 55.9 6.0 2.1 2 0 0 2 2 2 2 Villin headpiece domain SAM_2 PF07647.17 ETO10586.1 - 5.8e-08 32.7 0.1 1.2e-07 31.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO10586.1 - 5.5e-05 23.5 0.2 0.00012 22.4 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_KSR1 PF13543.6 ETO10586.1 - 0.0029 17.7 0.8 0.0029 17.7 0.8 2.7 1 1 2 3 3 3 1 SAM like domain present in kinase suppressor RAS 1 AAA_32 PF13654.6 ETO10586.1 - 0.013 14.3 10.8 0.019 13.7 10.2 1.6 1 1 0 1 1 1 0 AAA domain GST_C PF00043.25 ETO10586.1 - 0.054 13.7 1.1 0.12 12.6 0.2 2.1 3 0 0 3 3 3 0 Glutathione S-transferase, C-terminal domain LUC7 PF03194.15 ETO10586.1 - 0.22 11.2 10.9 0.25 11.0 10.5 1.3 1 1 0 1 1 1 0 LUC7 N_terminus dCache_2 PF08269.11 ETO10586.1 - 0.38 9.9 7.2 0.11 11.7 4.3 1.5 2 0 0 2 2 2 0 Cache domain GrpE PF01025.19 ETO10586.1 - 0.74 9.5 11.8 0.87 9.2 8.1 2.2 1 1 1 2 2 2 0 GrpE TBCC_N PF16752.5 ETO10586.1 - 1.8 9.1 11.9 3.5 8.1 10.1 2.3 2 1 0 2 2 2 0 Tubulin-specific chaperone C N-terminal domain DUF1664 PF07889.12 ETO10586.1 - 2.3 8.3 8.8 2.6 8.1 3.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Colicin-DNase PF12639.7 ETO10586.1 - 3.1 8.7 7.2 0.98 10.3 2.9 2.2 2 1 1 3 3 3 0 DNase/tRNase domain of colicin-like bacteriocin Exonuc_VII_L PF02601.15 ETO10586.1 - 3.9 6.9 7.6 5.2 6.6 7.3 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit mTERF PF02536.14 ETO10587.1 - 0.0073 15.3 0.3 0.0098 14.8 0.3 1.2 1 0 0 1 1 1 1 mTERF DUF2921 PF11145.8 ETO10589.1 - 0.026 12.4 0.1 0.028 12.3 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) partial_CstF PF15861.5 ETO10590.1 - 0.054 13.3 0.2 0.1 12.4 0.2 1.4 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain PDDEXK_6 PF04720.12 ETO10591.1 - 0.013 15.4 3.4 0.017 15.0 3.4 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function DUF1672 PF07901.11 ETO10591.1 - 0.026 13.9 10.8 0.027 13.8 10.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) Acyltransferase PF01553.21 ETO10593.1 - 1.6e-12 47.2 0.0 2.1e-12 46.8 0.0 1.2 1 0 0 1 1 1 1 Acyltransferase Csm1_N PF18504.1 ETO10594.1 - 0.028 14.7 5.7 0.046 14.0 5.7 1.3 1 0 0 1 1 1 0 Csm1 N-terminal domain PKcGMP_CC PF16808.5 ETO10594.1 - 0.035 14.0 5.3 0.035 14.0 5.3 1.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ACT_5 PF13710.6 ETO10594.1 - 0.12 12.3 0.6 0.17 11.7 0.6 1.2 1 0 0 1 1 1 0 ACT domain C4bp_oligo PF18453.1 ETO10594.1 - 5.3 7.3 8.7 3.3 8.0 1.8 2.2 2 0 0 2 2 2 0 Oligomerization domain of C4b-binding protein alpha Bap31_Bap29_C PF18035.1 ETO10594.1 - 6.3 6.9 12.4 0.35 10.9 1.5 2.1 2 1 1 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain HSP90 PF00183.18 ETO10595.1 - 8.4e-42 143.7 20.0 8.2e-36 124.0 3.0 2.5 2 0 0 2 2 2 2 Hsp90 protein TPR_12 PF13424.6 ETO10596.1 - 1.2e-46 156.9 0.9 1.7e-16 60.2 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10596.1 - 2.7e-31 106.5 0.4 2e-06 27.5 0.1 6.8 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10596.1 - 3.9e-28 95.4 4.2 2.1e-05 24.2 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10596.1 - 3.1e-27 92.4 24.8 2.6e-05 24.0 0.4 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10596.1 - 6.3e-26 89.1 36.1 2.6e-06 27.0 0.3 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10596.1 - 6.9e-24 82.0 33.3 8.5e-05 22.5 0.3 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10596.1 - 2.3e-09 36.8 26.6 0.00019 21.0 0.3 6.7 7 0 0 7 7 7 3 TPR repeat TPR_6 PF13174.6 ETO10596.1 - 8.7e-08 32.3 2.8 0.45 11.3 0.2 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO10596.1 - 8.1e-06 25.2 2.5 0.1 12.1 0.1 4.0 4 0 0 4 4 4 2 SHNi-TPR MIT PF04212.18 ETO10596.1 - 1.6e-05 24.9 13.6 0.73 9.9 0.1 6.3 6 0 0 6 6 6 3 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO10596.1 - 1.9e-05 24.7 6.8 29 5.4 0.1 6.8 7 0 0 7 7 6 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO10596.1 - 6.7e-05 22.9 1.8 0.00026 21.0 0.4 2.3 1 1 1 2 2 2 1 Caspase domain TPR_14 PF13428.6 ETO10596.1 - 0.0066 17.2 0.0 17 6.5 0.0 4.9 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO10596.1 - 0.012 15.1 0.0 0.15 11.4 0.0 2.4 2 1 0 2 2 2 0 MalT-like TPR region TPR_16 PF13432.6 ETO10596.1 - 0.041 14.5 0.0 27 5.5 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO10596.1 - 0.1 13.3 4.6 4.1 8.2 0.1 4.8 6 0 0 6 6 5 0 Sel1 repeat Toast_rack_N PF17115.5 ETO10596.1 - 2 8.8 5.3 0.61 10.4 0.3 2.7 2 0 0 2 2 2 0 N-terminal domain of toast_rack, DUF2154 ANAPC3 PF12895.7 ETO10596.1 - 9.8 6.5 9.5 0.55 10.5 0.3 3.4 3 1 2 5 5 4 0 Anaphase-promoting complex, cyclosome, subunit 3 ResIII PF04851.15 ETO10597.1 - 0.011 15.7 1.9 0.013 15.5 1.9 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ATP-synt_E PF05680.12 ETO10598.1 - 1.4 9.3 8.3 4.5 7.7 0.1 2.4 2 0 0 2 2 2 0 ATP synthase E chain NAGidase PF07555.13 ETO10599.1 - 0.0052 16.2 0.4 0.0052 16.2 0.4 1.1 1 0 0 1 1 1 1 beta-N-acetylglucosaminidase Ran-binding PF05508.11 ETO10599.1 - 0.0096 14.9 0.6 0.011 14.8 0.6 1.0 1 0 0 1 1 1 1 RanGTP-binding protein LPP20 PF02169.16 ETO10599.1 - 0.012 15.9 0.6 0.019 15.3 0.6 1.3 1 0 0 1 1 1 0 LPP20 lipoprotein DUF745 PF05335.13 ETO10599.1 - 0.014 15.1 1.8 0.017 14.8 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF745) DUF5089 PF17002.5 ETO10599.1 - 0.028 14.3 4.4 0.037 13.9 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5089) Tup_N PF08581.10 ETO10599.1 - 0.19 12.1 6.0 2 8.8 1.5 2.2 1 1 1 2 2 2 0 Tup N-terminal Rota_NSP4 PF01452.16 ETO10599.1 - 0.73 9.5 4.4 0.92 9.2 4.4 1.2 1 0 0 1 1 1 0 Rotavirus non structural protein WD40 PF00400.32 ETO10601.1 - 2.6e-30 104.0 23.0 8.2e-06 26.5 0.5 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10601.1 - 5.6e-12 45.8 1.8 0.055 13.8 0.0 4.7 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10601.1 - 4.3e-08 32.3 7.1 0.028 13.1 0.1 4.9 1 1 3 5 5 5 4 Nucleoporin Nup120/160 W_rich_C PF07483.11 ETO10601.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.6 4 1 0 4 4 4 0 Tryptophan-rich Synechocystis species C-terminal domain Kelch_6 PF13964.6 ETO10602.1 - 0.0033 17.7 0.2 0.014 15.6 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO10602.1 - 0.019 14.5 0.0 0.94 9.1 0.0 2.7 2 0 0 2 2 2 0 Kelch motif ComR_TPR PF18710.1 ETO10603.1 - 0.0088 15.6 0.1 0.012 15.2 0.1 1.3 1 1 0 1 1 1 1 ComR tetratricopeptide DUF669 PF05037.13 ETO10605.1 - 0.0013 18.8 0.9 0.0022 18.1 0.7 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF669) Tnp_22_trimer PF17489.2 ETO10605.1 - 0.17 11.9 0.5 0.17 11.9 0.5 2.3 3 0 0 3 3 3 0 L1 transposable element trimerization domain TMF_TATA_bd PF12325.8 ETO10606.1 - 0.29 11.4 6.4 0.3 11.3 2.0 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding APC_N_CC PF16689.5 ETO10607.1 - 0.05 13.7 0.3 3.4 7.8 0.1 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain DUF2508 PF10704.9 ETO10607.1 - 0.18 12.0 3.5 0.21 11.8 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) WD40 PF00400.32 ETO10608.1 - 7.2e-19 67.8 7.4 4.2e-06 27.4 0.3 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10608.1 - 0.016 15.5 0.2 2.4 8.5 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Kelch_5 PF13854.6 ETO10609.1 - 0.018 15.0 0.0 0.056 13.4 0.0 1.9 1 0 0 1 1 1 0 Kelch motif DUF1087 PF06465.13 ETO10609.1 - 0.29 11.2 2.5 0.27 11.3 0.9 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1087) Ribosomal_60s PF00428.19 ETO10611.1 - 0.0016 19.0 12.3 0.58 10.8 11.1 2.1 1 1 1 2 2 2 2 60s Acidic ribosomal protein RNA_polI_A34 PF08208.11 ETO10611.1 - 0.53 10.3 17.0 0.6 10.2 17.0 1.0 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NOA36 PF06524.12 ETO10611.1 - 1.2 8.4 15.1 1.4 8.1 15.1 1.1 1 0 0 1 1 1 0 NOA36 protein Cytomega_UL84 PF06284.11 ETO10611.1 - 2 6.7 10.8 2.3 6.5 10.8 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Nop14 PF04147.12 ETO10611.1 - 3.3 5.8 17.2 3.6 5.7 17.2 1.0 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 ETO10611.1 - 3.4 6.8 8.8 3.6 6.7 8.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter ODV-E18 PF10717.9 ETO10612.1 - 0.014 15.2 0.9 0.02 14.8 0.9 1.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ASFV_J13L PF05568.11 ETO10612.1 - 0.016 15.0 1.8 0.018 14.8 1.8 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein SNARE PF05739.19 ETO10612.1 - 0.27 11.3 6.4 0.48 10.5 6.4 1.4 1 0 0 1 1 1 0 SNARE domain DUF5385 PF17359.2 ETO10612.1 - 0.45 10.0 5.8 0.18 11.3 3.5 1.5 2 0 0 2 2 2 0 Family of unknown function (DUF5385) TMEM154 PF15102.6 ETO10612.1 - 2.9 7.8 7.3 0.27 11.1 2.8 1.6 2 0 0 2 2 2 0 TMEM154 protein family Cnd1 PF12717.7 ETO10613.1 - 0.19 11.8 0.5 0.31 11.1 0.5 1.3 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 GvpL_GvpF PF06386.11 ETO10613.1 - 9.8 6.0 10.5 0.25 11.2 4.0 1.6 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF Gpi16 PF04113.14 ETO10614.1 - 2.8e-29 102.0 0.0 3.2e-29 101.8 0.0 1.0 1 0 0 1 1 1 1 Gpi16 subunit, GPI transamidase component Lipase3_N PF03893.16 ETO10614.1 - 0.0057 16.6 0.1 1.1 9.3 0.0 2.5 3 0 0 3 3 3 2 Lipase 3 N-terminal region 7TM-7TMR_HD PF07698.11 ETO10614.1 - 0.18 11.5 0.1 0.25 11.1 0.1 1.1 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF2971 PF11185.8 ETO10614.1 - 0.32 12.2 5.3 16 6.8 2.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2971) TPR_12 PF13424.6 ETO10615.1 - 1.7e-79 262.1 27.2 6.5e-15 55.2 0.3 7.0 4 1 4 8 8 8 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10615.1 - 2e-50 167.4 5.4 1.8e-06 27.6 0.1 9.8 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10615.1 - 1.1e-41 137.8 18.5 4.2e-06 26.4 0.0 10.6 9 1 1 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10615.1 - 9.7e-40 132.8 61.1 4.4e-07 29.5 2.6 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10615.1 - 3.5e-33 111.0 43.1 1.4e-06 27.9 1.1 9.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10615.1 - 4.6e-26 88.8 70.8 1.4e-05 24.9 1.2 10.9 12 0 0 12 12 11 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO10615.1 - 2.8e-17 61.8 17.1 0.05 14.0 0.0 9.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO10615.1 - 3e-13 50.2 1.0 0.0024 18.5 0.1 5.9 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO10615.1 - 4.1e-08 33.4 14.2 0.3 11.8 0.1 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO10615.1 - 1.8e-06 28.3 0.0 13 6.9 0.0 6.9 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO10615.1 - 1.4e-05 24.6 0.0 0.0062 15.9 0.0 3.2 1 1 0 2 2 2 1 MalT-like TPR region DUF5113 PF17140.4 ETO10615.1 - 0.00034 20.5 29.7 0.86 9.4 0.3 7.6 5 3 3 8 8 8 3 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO10615.1 - 0.00056 19.5 53.0 0.0013 18.4 1.7 10.6 8 3 3 11 11 11 4 TPR repeat PPR PF01535.20 ETO10615.1 - 0.00096 19.2 22.1 0.098 12.9 0.3 7.4 7 0 0 7 7 7 1 PPR repeat DUF4810 PF16068.5 ETO10615.1 - 0.0049 17.4 14.1 1.8 9.2 0.3 5.1 5 1 0 5 5 4 2 Domain of unknown function (DUF4810) Peptidase_C16 PF01831.17 ETO10615.1 - 0.0099 15.6 0.2 0.02 14.7 0.2 1.4 1 0 0 1 1 1 1 Peptidase C16 family TPR_19 PF14559.6 ETO10615.1 - 0.0099 16.4 5.2 9.9 6.8 0.0 5.1 3 1 3 6 6 6 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO10615.1 - 0.012 15.8 0.0 19 5.5 0.0 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO10615.1 - 0.017 15.3 24.1 1.2 9.4 0.4 6.1 4 2 1 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO10615.1 - 0.046 13.7 25.0 0.09 12.8 1.1 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO10615.1 - 0.26 10.7 13.3 3.9 6.9 0.1 4.9 4 1 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like RPN7 PF10602.9 ETO10615.1 - 0.32 10.7 17.1 0.21 11.3 1.0 4.2 3 3 2 5 5 5 0 26S proteasome subunit RPN7 HTH_Bact PF18768.1 ETO10615.1 - 0.52 9.9 12.7 18 5.0 1.9 7.2 7 1 0 7 7 7 0 Helix-turn-helix bacterial domain WD40 PF00400.32 ETO10616.1 - 5.2e-07 30.3 0.9 8.6e-07 29.6 0.9 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat FapA PF03961.13 ETO10616.1 - 0.019 13.6 3.1 0.018 13.7 3.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Geminin PF07412.12 ETO10616.1 - 0.019 14.7 3.8 0.019 14.7 3.8 1.5 1 1 0 1 1 1 0 Geminin TMPIT PF07851.13 ETO10616.1 - 0.024 13.9 2.6 0.026 13.8 2.6 1.1 1 0 0 1 1 1 0 TMPIT-like protein She9_MDM33 PF05546.11 ETO10616.1 - 0.028 14.2 4.4 0.035 13.9 4.4 1.2 1 0 0 1 1 1 0 She9 / Mdm33 family HSCB_C PF07743.13 ETO10616.1 - 0.14 12.7 2.8 0.19 12.2 2.8 1.2 1 0 0 1 1 1 0 HSCB C-terminal oligomerisation domain Med4 PF10018.9 ETO10616.1 - 0.17 11.6 5.7 0.19 11.4 5.7 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 Orbi_VP5 PF00901.17 ETO10616.1 - 0.26 9.7 3.9 0.41 9.0 3.9 1.5 1 1 0 1 1 1 0 Orbivirus outer capsid protein VP5 ABC_membrane_2 PF06472.15 ETO10617.1 - 9.8e-14 51.4 4.8 6.7e-07 29.0 0.2 2.0 2 0 0 2 2 2 2 ABC transporter transmembrane region 2 Mei5_like PF17021.5 ETO10617.1 - 0.17 11.9 0.0 0.38 10.8 0.0 1.5 1 1 0 1 1 1 0 Putative double-strand recombination repair-like DSPc PF00782.20 ETO10619.1 - 7.6e-26 90.5 0.2 8.7e-26 90.3 0.2 1.0 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF4456 PF14644.6 ETO10619.1 - 0.039 13.6 0.1 0.078 12.7 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4456) WD40 PF00400.32 ETO10620.1 - 3.5e-17 62.5 4.9 8e-05 23.3 0.2 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10620.1 - 0.00077 19.7 0.3 1 9.7 0.0 3.1 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10620.1 - 0.0022 16.7 0.2 4.4 5.8 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 zf-RVT PF13966.6 ETO10621.1 - 1.2e-07 32.4 1.5 2.7e-07 31.2 0.4 2.2 2 0 0 2 2 2 1 zinc-binding in reverse transcriptase RVT_1 PF00078.27 ETO10621.1 - 0.00011 21.8 0.1 0.00039 20.0 0.1 1.9 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) HU-DNA_bdg PF14848.6 ETO10623.1 - 0.021 14.9 0.3 0.031 14.3 0.3 1.2 1 0 0 1 1 1 0 DNA-binding domain WD40 PF00400.32 ETO10624.1 - 1.5e-14 54.1 3.1 0.00064 20.5 0.0 4.1 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10624.1 - 0.053 13.8 0.0 21 5.5 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain NifU PF01106.17 ETO10627.1 - 4.8e-24 84.3 0.0 7.7e-24 83.6 0.0 1.3 1 0 0 1 1 1 1 NifU-like domain Nfu_N PF08712.11 ETO10627.1 - 4.8e-22 77.8 0.5 9.2e-22 76.9 0.5 1.5 1 0 0 1 1 1 1 Scaffold protein Nfu/NifU N terminal PH PF00169.29 ETO10630.1 - 2.8e-08 34.2 1.2 1.1e-07 32.3 1.2 2.1 1 0 0 1 1 1 1 PH domain Mucin PF01456.17 ETO10630.1 - 1.2e-05 25.3 15.0 1.2e-05 25.3 15.0 2.6 3 0 0 3 3 3 1 Mucin-like glycoprotein PH_8 PF15409.6 ETO10630.1 - 0.003 17.8 0.2 0.011 16.0 0.2 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO10630.1 - 1.9 8.9 12.0 0.33 11.4 4.0 3.3 3 1 0 3 3 3 0 Pleckstrin homology domain FSA_C PF10479.9 ETO10630.1 - 6.2 4.8 22.0 0.28 9.3 16.2 1.6 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus 7tm_3 PF00003.22 ETO10632.1 - 2.1e-05 24.4 7.4 3.6e-05 23.6 7.4 1.3 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR 7TMR-DISM_7TM PF07695.11 ETO10632.1 - 0.00038 20.4 6.2 0.00054 19.9 6.2 1.2 1 0 0 1 1 1 1 7TM diverse intracellular signalling 7TM-7TMR_HD PF07698.11 ETO10632.1 - 0.00084 19.2 5.3 0.00084 19.2 5.3 2.0 1 1 0 2 2 2 1 7TM receptor with intracellular HD hydrolase DUF1461 PF07314.11 ETO10632.1 - 0.0055 16.6 9.8 0.016 15.1 3.7 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1461) DUF4271 PF14093.6 ETO10632.1 - 0.0062 16.5 17.3 0.35 10.8 0.5 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4271) Ninjurin PF04923.12 ETO10632.1 - 0.0089 16.0 5.6 0.038 13.9 2.1 2.1 2 0 0 2 2 2 1 Ninjurin DUF805 PF05656.14 ETO10632.1 - 0.0097 16.3 2.3 0.015 15.7 2.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF805) SUR7 PF06687.12 ETO10632.1 - 0.023 14.3 3.8 0.1 12.2 0.2 2.0 2 0 0 2 2 2 0 SUR7/PalI family TrmB PF01978.19 ETO10632.1 - 0.062 13.2 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB DUF4293 PF14126.6 ETO10632.1 - 0.067 13.4 5.9 0.35 11.1 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) LapA_dom PF06305.11 ETO10632.1 - 0.15 11.8 5.1 1.9 8.3 0.0 2.6 3 0 0 3 3 2 0 Lipopolysaccharide assembly protein A domain RIFIN PF02009.16 ETO10632.1 - 0.16 11.8 0.1 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 Rifin DUF4199 PF13858.6 ETO10632.1 - 0.24 11.8 13.3 2 8.8 5.1 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF4199) FtsH_ext PF06480.15 ETO10632.1 - 0.32 11.4 8.3 4.4 7.7 0.2 3.1 3 0 0 3 3 3 0 FtsH Extracellular Glucos_trans_II PF14264.6 ETO10632.1 - 0.45 9.8 17.2 2.8 7.2 17.2 1.9 1 1 0 1 1 1 0 Glucosyl transferase GtrII Gemini_mov PF01708.16 ETO10632.1 - 0.48 10.2 3.7 0.85 9.4 0.3 2.5 2 1 1 3 3 3 0 Geminivirus putative movement protein OppC_N PF12911.7 ETO10632.1 - 0.5 10.4 15.4 2.4 8.2 3.2 3.5 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C Intg_mem_TP0381 PF09529.10 ETO10632.1 - 0.56 9.7 15.0 0.25 10.8 4.6 2.1 1 1 0 2 2 2 0 Integral membrane protein (intg_mem_TP0381) Sulfate_transp PF00916.20 ETO10632.1 - 0.68 8.6 6.9 1.9 7.2 7.2 1.5 1 1 0 1 1 1 0 Sulfate permease family Toxin_GhoT_OrtT PF10753.9 ETO10632.1 - 0.72 10.1 0.1 0.72 10.1 0.1 3.6 4 0 0 4 4 4 0 Toxin GhoT_OrtT DUF2207 PF09972.9 ETO10632.1 - 0.81 8.4 11.9 3.6 6.3 11.9 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Spo7 PF03907.13 ETO10632.1 - 0.99 8.8 3.3 0.36 10.3 0.4 1.6 2 0 0 2 2 2 0 Spo7-like protein MscL PF01741.18 ETO10632.1 - 1.5 9.1 12.7 1.1 9.6 0.4 2.7 2 1 1 3 3 3 0 Large-conductance mechanosensitive channel, MscL CcmD PF04995.14 ETO10632.1 - 1.8 8.7 0.0 1.8 8.7 0.0 2.7 4 0 0 4 4 2 0 Heme exporter protein D (CcmD) PHO4 PF01384.20 ETO10632.1 - 2.2 7.3 4.1 4.5 6.2 4.2 1.5 1 1 0 1 1 1 0 Phosphate transporter family DUF3810 PF12725.7 ETO10632.1 - 2.3 7.5 13.3 1.2 8.4 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) RAMP4 PF06624.12 ETO10632.1 - 2.8 8.0 5.4 1.8 8.7 0.3 2.7 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 DUF4999 PF16390.5 ETO10632.1 - 8.3 6.7 7.2 0.46 10.8 1.2 1.9 2 1 0 2 2 2 0 Domain of unknown function EF-hand_1 PF00036.32 ETO10634.1 - 1e-12 46.6 1.5 6.6e-05 22.2 0.1 3.3 3 0 0 3 3 3 2 EF hand SpoU_methylase PF00588.19 ETO10634.1 - 5.9e-12 45.9 0.0 3.5e-11 43.4 0.0 2.0 2 0 0 2 2 2 1 SpoU rRNA Methylase family EF-hand_7 PF13499.6 ETO10634.1 - 8.6e-12 45.3 6.0 8.9e-09 35.7 1.2 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO10634.1 - 1.5e-10 40.1 3.2 3.6e-05 23.4 0.1 3.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ETO10634.1 - 1.2e-09 38.0 3.0 5.9e-05 23.0 0.7 2.6 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 ETO10634.1 - 1.1e-07 31.0 6.5 0.00084 18.7 0.1 2.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO10634.1 - 9.3e-07 28.6 0.1 0.034 14.0 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain pair zf-TRAF PF02176.18 ETO10635.1 - 1.4e-05 25.7 5.9 4.8e-05 24.0 5.9 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger WD40 PF00400.32 ETO10635.1 - 0.15 12.9 2.1 0.71 10.8 2.1 2.1 1 1 0 1 1 1 0 WD domain, G-beta repeat zf-C2H2_jaz PF12171.8 ETO10636.1 - 5.7e-08 32.8 9.8 0.00031 20.9 1.6 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 ETO10636.1 - 1.1e-07 31.9 20.3 5.5e-06 26.5 3.6 2.9 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-met PF12874.7 ETO10636.1 - 6.8e-07 29.5 9.9 0.0052 17.1 2.1 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ETO10636.1 - 4e-06 27.2 16.0 0.0015 19.2 1.6 3.2 3 0 0 3 3 3 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETO10636.1 - 2e-05 24.5 8.0 0.00069 19.6 1.5 2.4 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO10636.1 - 0.00054 20.3 18.6 0.00099 19.4 0.5 4.1 4 0 0 4 4 4 2 Zinc-finger double domain RGCC PF15151.6 ETO10636.1 - 0.022 15.0 0.0 0.04 14.2 0.0 1.5 1 0 0 1 1 1 0 Response gene to complement 32 protein family zinc_ribbon_15 PF17032.5 ETO10636.1 - 0.043 14.6 2.5 0.043 14.6 2.5 1.6 2 0 0 2 2 2 0 zinc-ribbon family zf-C2H2_11 PF16622.5 ETO10636.1 - 0.077 12.8 1.3 1.3 8.8 0.1 2.4 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-BED PF02892.15 ETO10636.1 - 0.11 12.6 9.6 1.2 9.2 1.8 3.1 2 1 1 3 3 3 0 BED zinc finger Sgf11 PF08209.11 ETO10636.1 - 0.33 10.5 3.2 10 5.8 0.3 2.2 2 0 0 2 2 2 0 Sgf11 (transcriptional regulation protein) C1_2 PF03107.16 ETO10636.1 - 0.37 11.2 3.9 3.4 8.0 3.9 2.3 1 1 0 1 1 1 0 C1 domain zf-Di19 PF05605.12 ETO10636.1 - 0.42 10.9 10.2 0.052 13.8 5.6 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-MYST PF17772.1 ETO10636.1 - 1.7 8.3 8.8 2.9 7.5 1.2 2.8 2 1 1 3 3 3 0 MYST family zinc finger domain zf-C2HC_2 PF13913.6 ETO10636.1 - 2.8 8.0 5.7 6.1 6.9 0.2 3.1 3 0 0 3 3 3 0 zinc-finger of a C2HC-type DDE_3 PF13358.6 ETO10637.1 - 2.7e-13 49.9 2.6 6.5e-13 48.7 2.0 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 ETO10637.1 - 3.7e-06 27.1 0.9 3.7e-06 27.1 0.9 1.7 2 0 0 2 2 2 1 Transposase rve PF00665.26 ETO10637.1 - 0.037 14.2 0.0 0.11 12.7 0.0 1.9 1 1 0 1 1 1 0 Integrase core domain zf-CCHC_4 PF14392.6 ETO10638.1 - 0.15 11.8 2.2 0.54 10.0 0.5 2.3 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC PF00098.23 ETO10638.1 - 1.2 9.3 8.7 0.85 9.8 0.6 2.8 2 1 0 2 2 2 0 Zinc knuckle Macoilin PF09726.9 ETO10640.1 - 0.12 10.9 9.3 0.15 10.6 9.3 1.1 1 0 0 1 1 1 0 Macoilin family DAG_kinase_N PF14513.6 ETO10640.1 - 0.39 10.9 6.0 0.33 11.1 4.9 1.4 1 1 0 1 1 1 0 Diacylglycerol kinase N-terminus Med13_C PF06333.12 ETO10640.1 - 0.89 8.8 7.2 1.1 8.5 7.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Mucin PF01456.17 ETO10640.1 - 1.9 8.5 19.6 3.2 7.7 19.6 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3042 PF11240.8 ETO10641.1 - 0.15 12.1 1.2 0.55 10.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) Frigida PF07899.11 ETO10641.1 - 0.44 9.8 2.6 1 8.5 2.6 1.6 1 0 0 1 1 1 0 Frigida-like protein Menin PF05053.13 ETO10641.1 - 1.9 6.7 11.2 2.4 6.4 11.2 1.1 1 0 0 1 1 1 0 Menin RBFA PF02033.18 ETO10642.1 - 0.0019 18.7 0.0 0.0067 16.9 0.0 1.9 1 1 1 2 2 2 1 Ribosome-binding factor A Shugoshin_N PF07558.11 ETO10645.1 - 0.004 17.0 3.0 0.011 15.6 1.0 2.3 2 0 0 2 2 2 1 Shugoshin N-terminal coiled-coil region WD40_alt PF14077.6 ETO10645.1 - 0.11 12.4 0.3 0.23 11.4 0.3 1.5 1 0 0 1 1 1 0 Alternative WD40 repeat motif ADIP PF11559.8 ETO10645.1 - 0.18 11.8 16.1 0.27 11.3 16.1 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Spc7 PF08317.11 ETO10645.1 - 0.27 10.1 11.6 0.27 10.1 11.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETO10645.1 - 0.29 11.2 3.8 0.32 11.0 3.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF3573 PF12097.8 ETO10645.1 - 0.5 9.1 3.1 0.58 8.9 3.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) Cellulose_synt PF03552.14 ETO10645.1 - 0.73 8.2 2.7 0.77 8.2 2.7 1.0 1 0 0 1 1 1 0 Cellulose synthase TMF_DNA_bd PF12329.8 ETO10645.1 - 1.3 9.0 18.1 0.057 13.4 11.7 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF4407 PF14362.6 ETO10645.1 - 1.5 8.1 6.6 1.8 7.9 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ApoO PF09769.9 ETO10645.1 - 1.8 8.6 3.7 4.2 7.3 3.0 1.8 1 1 1 2 2 2 0 Apolipoprotein O Paramyxo_ncap PF00973.19 ETO10645.1 - 1.8 7.4 7.6 2.1 7.2 7.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein V_ATPase_I PF01496.19 ETO10645.1 - 2.8 5.8 7.0 2.7 5.8 7.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 ETO10645.1 - 3.5 6.4 5.5 4 6.2 5.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein APG6_N PF17675.1 ETO10645.1 - 4 8.0 17.2 6.6 7.3 17.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region CCDC-167 PF15188.6 ETO10645.1 - 7.9 6.9 11.1 1.4 9.3 3.1 2.7 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 DUF2207 PF09972.9 ETO10646.1 - 0.00064 18.6 0.5 0.00087 18.2 0.5 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) NPV_P10 PF05531.12 ETO10646.1 - 0.072 13.6 0.4 0.32 11.5 0.1 1.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Pex24p PF06398.11 ETO10646.1 - 0.14 11.1 1.2 0.18 10.7 1.2 1.3 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin AvrPto PF11592.8 ETO10646.1 - 0.18 11.8 0.4 0.27 11.3 0.4 1.3 1 0 0 1 1 1 0 Central core of the bacterial effector protein AvrPto DUF3106 PF11304.8 ETO10646.1 - 0.38 11.3 5.5 0.5 10.9 5.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3106) DASH_Hsk3 PF08227.11 ETO10646.1 - 0.42 11.0 3.4 6.1 7.3 0.3 2.6 2 0 0 2 2 2 0 DASH complex subunit Hsk3 like Jnk-SapK_ap_N PF09744.9 ETO10646.1 - 0.47 10.7 7.8 0.67 10.2 7.8 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DASH_Dam1 PF08653.10 ETO10646.1 - 0.76 9.6 5.8 6.7 6.6 0.1 3.3 2 1 1 3 3 3 0 DASH complex subunit Dam1 FapA PF03961.13 ETO10646.1 - 1.7 7.1 6.9 2 7.0 6.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 ETO10646.1 - 2.3 7.7 3.9 2.9 7.4 3.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 ETO10646.1 - 3.2 8.1 11.6 5.5 7.3 11.6 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2457 PF10446.9 ETO10649.1 - 0.012 14.7 8.6 0.015 14.5 8.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PspB PF06667.12 ETO10650.1 - 0.022 14.8 0.4 0.066 13.3 0.4 1.8 1 0 0 1 1 1 0 Phage shock protein B POX PF07526.11 ETO10650.1 - 0.081 13.5 3.5 0.49 11.0 0.1 2.5 3 0 0 3 3 3 0 Associated with HOX EIIBC-GUT_N PF03612.14 ETO10650.1 - 0.41 10.4 5.3 1.2 8.8 0.5 2.3 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus CPSF100_C PF13299.6 ETO10650.1 - 0.47 10.6 4.8 8.2 6.6 0.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF3276 PF11680.8 ETO10650.1 - 2.4 8.3 8.1 0.55 10.4 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3276) DUF3439 PF11921.8 ETO10651.1 - 0.007 16.3 9.1 0.007 16.3 9.1 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO10651.1 - 0.0083 14.4 3.8 0.009 14.3 3.8 1.1 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO10651.1 - 0.035 14.1 8.7 0.035 14.1 8.7 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein TcpE PF12648.7 ETO10652.1 - 0.17 12.4 14.6 0.093 13.3 4.2 2.2 2 0 0 2 2 2 0 TcpE family WD40 PF00400.32 ETO10653.1 - 1.9e-47 158.2 27.2 9.5e-11 42.1 0.4 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10653.1 - 5.7e-20 71.4 4.2 0.0011 19.2 0.0 5.7 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO10653.1 - 1.4e-11 44.3 0.4 0.0015 17.9 0.0 4.0 1 1 3 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO10653.1 - 4.1e-07 30.1 0.0 0.0047 16.8 0.0 3.0 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO10653.1 - 1.1e-06 27.8 0.3 2.6 6.9 0.0 4.7 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO10653.1 - 1.6e-06 27.9 1.1 3.7 7.6 0.0 4.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO10653.1 - 0.00015 20.5 6.1 0.44 9.1 0.8 3.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO10653.1 - 0.0077 14.8 1.9 0.59 8.6 0.1 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain Frtz PF11768.8 ETO10653.1 - 0.012 13.9 0.0 0.074 11.4 0.0 2.1 1 1 2 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETO10653.1 - 0.015 15.4 8.5 4.5 7.4 0.3 4.6 1 1 4 5 5 5 0 Family of unknown function (DUF5570) TolB_N PF04052.13 ETO10653.1 - 0.019 15.1 0.0 40 4.4 0.0 4.0 5 0 0 5 5 5 0 TolB amino-terminal domain DUF4624 PF15417.6 ETO10653.1 - 0.044 13.6 0.1 0.29 10.9 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4624) Big_7 PF17957.1 ETO10653.1 - 0.17 12.7 7.0 15 6.4 0.5 4.4 3 2 0 3 3 3 0 Bacterial Ig domain Proteasome_A_N PF10584.9 ETO10653.1 - 1.4 8.7 16.0 20 5.0 0.1 5.3 5 1 1 6 6 6 0 Proteasome subunit A N-terminal signature PARM PF17061.5 ETO10654.1 - 0.025 14.7 25.5 0.03 14.5 25.5 1.1 1 0 0 1 1 1 0 PARM TFIIA PF03153.13 ETO10654.1 - 0.065 13.2 19.8 0.074 13.0 19.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SOG2 PF10428.9 ETO10654.1 - 0.24 10.6 28.9 0.29 10.3 28.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SPX PF03105.19 ETO10654.1 - 1.9 8.3 22.0 2.8 7.7 22.0 1.4 1 0 0 1 1 1 0 SPX domain Apt1 PF10351.9 ETO10654.1 - 3.8 6.3 19.7 4.7 5.9 19.7 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ndc1_Nup PF09531.10 ETO10654.1 - 4.9 5.7 16.8 5.3 5.6 16.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PP2C PF00481.21 ETO10656.1 - 3.1e-12 46.7 0.0 3.8e-12 46.4 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C Pkinase PF00069.25 ETO10658.1 - 6.7e-08 32.2 0.1 1e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain ABC_tran PF00005.27 ETO10658.1 - 1.6e-07 31.9 0.0 3.9e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 ABC transporter Pkinase_Tyr PF07714.17 ETO10658.1 - 0.00022 20.6 0.2 0.00036 19.9 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CBAH PF02275.18 ETO10659.1 - 0.0088 15.7 0.5 0.025 14.2 0.0 1.7 2 0 0 2 2 2 1 Linear amide C-N hydrolases, choloylglycine hydrolase family DUF1629 PF07791.11 ETO10659.1 - 0.12 12.5 0.0 0.21 11.8 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1629) DUF812 PF05667.11 ETO10660.1 - 0.0008 18.4 3.3 0.00085 18.3 3.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) CENP-Q PF13094.6 ETO10660.1 - 0.0052 17.0 1.9 0.013 15.7 1.9 1.6 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit Laminin_II PF06009.12 ETO10660.1 - 0.0074 16.3 2.9 0.017 15.1 2.9 1.6 1 0 0 1 1 1 1 Laminin Domain II DUF3450 PF11932.8 ETO10660.1 - 0.014 14.7 7.7 0.02 14.2 7.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF3958 PF13125.6 ETO10660.1 - 0.019 15.2 5.1 0.029 14.6 2.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3958) DUF1664 PF07889.12 ETO10660.1 - 0.023 14.7 3.0 0.023 14.7 3.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF1204 PF06721.11 ETO10660.1 - 0.03 13.8 1.3 0.052 13.0 1.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1204) Herpes_UL6 PF01763.16 ETO10660.1 - 0.052 12.1 3.9 0.072 11.6 3.9 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like bZIP_1 PF00170.21 ETO10660.1 - 0.062 13.4 10.0 0.97 9.6 4.6 2.7 1 1 1 2 2 2 0 bZIP transcription factor UPF0242 PF06785.11 ETO10660.1 - 0.078 13.1 8.5 0.13 12.3 8.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Cep57_MT_bd PF06657.13 ETO10660.1 - 0.099 13.1 3.7 0.23 12.0 3.7 1.5 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 Snapin_Pallidin PF14712.6 ETO10660.1 - 0.12 12.9 6.6 0.27 11.7 6.6 1.6 1 0 0 1 1 1 0 Snapin/Pallidin ADIP PF11559.8 ETO10660.1 - 0.13 12.4 11.0 0.21 11.7 11.0 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding TolA_bind_tri PF16331.5 ETO10660.1 - 0.14 12.2 13.8 0.039 14.0 8.2 2.5 2 1 1 3 3 3 0 TolA binding protein trimerisation ZapB PF06005.12 ETO10660.1 - 0.15 12.5 13.2 0.17 12.4 10.8 2.3 2 1 0 2 2 2 0 Cell division protein ZapB LPP PF04728.13 ETO10660.1 - 0.17 12.3 9.4 1 9.8 1.4 3.2 2 1 1 3 3 3 0 Lipoprotein leucine-zipper CENP-F_leu_zip PF10473.9 ETO10660.1 - 0.26 11.3 14.6 0.094 12.7 10.7 2.2 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 T3SSipB PF16535.5 ETO10660.1 - 0.26 11.7 6.7 0.14 12.6 4.3 1.7 2 0 0 2 2 2 0 Type III cell invasion protein SipB NYD-SP28_assoc PF14775.6 ETO10660.1 - 0.28 11.3 4.1 0.16 12.1 1.0 2.1 1 1 1 2 2 2 0 Sperm tail C-terminal domain Rx_N PF18052.1 ETO10660.1 - 0.51 10.6 4.4 2.3 8.6 1.3 2.3 2 0 0 2 2 2 0 Rx N-terminal domain CLZ PF16526.5 ETO10660.1 - 0.6 10.5 7.3 0.37 11.2 1.6 2.7 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF948 PF06103.11 ETO10660.1 - 1.3 9.3 3.9 29 5.0 0.1 2.3 2 1 0 3 3 2 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 ETO10660.1 - 6 7.3 9.6 0.63 10.5 3.0 2.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 ETO10660.1 - 9 6.7 11.3 1.4 9.3 7.2 1.8 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Tubulin PF00091.25 ETO10661.1 - 4.4e-05 23.8 0.5 0.00016 21.9 0.0 2.1 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain KIP1 PF07765.12 ETO10661.1 - 0.0097 16.0 0.3 0.034 14.3 0.3 1.9 1 0 0 1 1 1 1 KIP1-like protein Selenoprotein_S PF06936.11 ETO10661.1 - 0.03 14.1 0.9 0.03 14.1 0.9 1.6 2 0 0 2 2 2 0 Selenoprotein S (SelS) IRK_C PF17655.1 ETO10662.1 - 5.3e-21 75.0 0.0 8.5e-21 74.3 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain Fucose_iso_N2 PF07882.12 ETO10662.1 - 5.8 6.5 7.6 3.8 7.1 5.4 1.7 2 0 0 2 2 2 0 L-fucose isomerase, second N-terminal domain STAS PF01740.21 ETO10663.1 - 1.2e-18 66.8 0.0 2.2e-18 66.0 0.0 1.4 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO10663.1 - 0.00036 19.4 0.8 0.00065 18.6 0.8 1.4 1 0 0 1 1 1 1 Sulfate permease family Herpes_LMP2 PF07415.11 ETO10664.1 - 0.019 13.8 0.0 0.021 13.6 0.0 1.1 1 0 0 1 1 1 0 Gammaherpesvirus latent membrane protein (LMP2) protein EF-hand_6 PF13405.6 ETO10665.1 - 0.00054 19.7 0.3 0.016 15.1 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain Myotub-related PF06602.14 ETO10665.1 - 0.012 14.6 0.3 0.017 14.1 0.3 1.4 1 0 0 1 1 1 0 Myotubularin-like phosphatase domain EF-hand_7 PF13499.6 ETO10665.1 - 0.05 14.1 0.4 0.19 12.2 0.0 2.2 3 1 0 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.32 ETO10665.1 - 0.12 12.0 0.3 0.66 9.7 0.1 2.4 3 0 0 3 3 3 0 EF hand DUF4181 PF13789.6 ETO10667.1 - 0.24 11.7 3.3 0.13 12.5 1.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4181) Kinesin PF00225.23 ETO10668.1 - 9.6e-49 166.1 9.4 1.2e-28 100.1 1.7 3.2 2 1 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 ETO10668.1 - 0.0068 16.3 2.4 0.051 13.5 0.0 3.0 2 0 0 2 2 2 1 Microtubule binding DivIC PF04977.15 ETO10668.1 - 0.15 11.9 0.0 0.15 11.9 0.0 3.7 3 1 0 3 3 3 0 Septum formation initiator B56 PF01603.20 ETO10669.1 - 0.00043 19.4 0.1 0.00043 19.4 0.1 2.0 2 1 0 2 2 2 1 Protein phosphatase 2A regulatory B subunit (B56 family) Lin-8 PF03353.15 ETO10669.1 - 0.1 12.2 19.3 0.12 11.9 19.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist BUD22 PF09073.10 ETO10669.1 - 0.14 11.5 27.6 0.17 11.2 27.6 1.1 1 0 0 1 1 1 0 BUD22 AF-4 PF05110.13 ETO10669.1 - 0.21 9.6 29.3 0.27 9.3 29.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TFIIF_alpha PF05793.12 ETO10669.1 - 0.93 8.0 30.4 1 7.8 30.4 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Transformer PF06495.11 ETO10669.1 - 3.1 7.9 8.0 4.4 7.3 8.0 1.3 1 0 0 1 1 1 0 Fruit fly transformer protein TAF4 PF05236.14 ETO10669.1 - 3.7 7.2 24.7 4.2 7.1 24.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Peptidase_S64 PF08192.11 ETO10669.1 - 3.9 5.8 27.3 4.6 5.6 27.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Apt1 PF10351.9 ETO10669.1 - 6.1 5.6 25.2 7.5 5.3 25.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Utp14 PF04615.13 ETO10669.1 - 7 5.1 34.5 7.9 4.9 34.5 1.0 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 ETO10669.1 - 7.1 3.6 24.6 8.3 3.4 24.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 ETO10669.1 - 7.2 5.7 26.0 7.7 5.6 26.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein WD40 PF00400.32 ETO10671.1 - 6.7e-36 121.7 27.1 5e-08 33.5 0.3 7.3 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10671.1 - 5.9e-11 42.5 2.0 0.0083 16.4 0.0 5.6 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10671.1 - 1.1e-10 40.8 7.0 0.0013 17.4 0.0 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 Read-through PF16814.5 ETO10671.1 - 0.093 12.5 0.7 0.61 9.9 0.1 2.7 3 0 0 3 3 3 0 Read-through domain WD40 PF00400.32 ETO10672.1 - 3e-12 46.8 0.4 1.1e-06 29.2 0.6 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10672.1 - 2.5e-06 27.7 0.1 0.0082 16.4 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO10672.1 - 0.00078 19.3 0.2 0.03 14.3 0.7 2.4 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Ras PF00071.22 ETO10673.1 - 9.3e-36 122.9 4.3 5.1e-34 117.2 4.3 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO10673.1 - 2.2e-14 53.7 11.1 5.4e-14 52.4 4.7 3.4 3 1 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO10673.1 - 7.8e-07 28.7 3.6 1.8e-05 24.3 3.6 2.3 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO10673.1 - 3.3e-05 23.9 1.6 0.0012 18.8 0.5 2.3 2 0 0 2 2 2 1 RsgA GTPase Gtr1_RagA PF04670.12 ETO10673.1 - 0.00011 21.7 0.9 0.00022 20.6 0.9 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO10673.1 - 0.00025 20.7 0.5 0.00058 19.5 0.5 1.7 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO10673.1 - 0.00032 20.8 0.5 0.00085 19.4 0.1 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ETO10673.1 - 0.0095 15.7 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 ETO10673.1 - 0.011 15.3 0.3 0.17 11.4 0.1 2.5 2 1 0 2 2 2 0 Ferrous iron transport protein B INSC_LBD PF16748.5 ETO10673.1 - 0.02 14.3 0.0 0.041 13.3 0.0 1.4 1 0 0 1 1 1 0 Inscuteable LGN-binding domain Colicin_K PF17500.2 ETO10674.1 - 0.005 17.4 0.1 0.0066 17.0 0.1 1.1 1 0 0 1 1 1 1 Colicin-K Nup_retrotrp_bd PF10599.9 ETO10674.1 - 0.042 14.5 2.5 0.052 14.2 2.5 1.2 1 0 0 1 1 1 0 Retro-transposon transporting motif DUF4175 PF13779.6 ETO10675.1 - 0.15 10.0 0.4 0.18 9.7 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Baculo_Y142 PF04913.12 ETO10677.1 - 0.011 14.4 0.0 0.014 14.1 0.0 1.1 1 0 0 1 1 1 0 Baculovirus Y142 protein SR-25 PF10500.9 ETO10679.1 - 2.5 7.7 19.7 2.3 7.8 19.7 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF148 PF02520.17 ETO10681.1 - 0.14 12.3 4.2 0.11 12.6 2.1 1.8 2 0 0 2 2 2 0 Domain of unknown function DUF148 RAG1_imp_bd PF12560.8 ETO10682.1 - 0.045 13.3 0.5 0.065 12.8 0.5 1.1 1 0 0 1 1 1 0 RAG1 importin binding BatA PF07584.11 ETO10682.1 - 2.8 8.4 0.0 2.8 8.4 0.0 3.6 4 0 0 4 4 4 0 Aerotolerance regulator N-terminal CLPTM1 PF05602.12 ETO10684.1 - 0.035 13.1 0.3 0.047 12.7 0.3 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) RPA43_OB PF17875.1 ETO10684.1 - 4.2 8.0 5.6 22 5.7 5.6 2.1 1 1 0 1 1 1 0 RPA43 OB domain in RNA Pol I Fez1 PF06818.15 ETO10686.1 - 4 7.9 11.2 5.2 7.5 11.2 1.2 1 0 0 1 1 1 0 Fez1 WD40 PF00400.32 ETO10687.1 - 3.9e-26 90.8 16.8 1.1e-05 26.1 2.4 5.0 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10687.1 - 1.2e-11 44.7 2.2 0.0036 17.6 0.1 4.1 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10687.1 - 2.5e-07 29.7 4.7 0.57 8.8 0.1 4.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO10687.1 - 0.047 13.8 3.7 2.3 8.4 0.1 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5570) Kelch_6 PF13964.6 ETO10690.1 - 0.00052 20.2 5.9 7.2 7.1 0.0 6.0 6 1 1 7 7 7 2 Kelch motif Kelch_4 PF13418.6 ETO10690.1 - 0.037 14.0 0.7 2.6 8.1 0.1 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain ABC2_membrane_3 PF12698.7 ETO10690.1 - 0.82 8.7 5.0 2.1 7.3 5.0 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein ACOX PF01756.19 ETO10692.1 - 1.1e-06 28.4 0.8 1.8e-06 27.7 0.1 1.7 2 1 0 2 2 2 1 Acyl-CoA oxidase DUF3496 PF12001.8 ETO10693.1 - 0.1 13.0 12.1 0.35 11.2 12.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) DUF16 PF01519.16 ETO10693.1 - 1.1 9.7 24.6 5.1 7.6 7.4 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF1664 PF07889.12 ETO10693.1 - 1.1 9.2 11.4 1.9 8.5 3.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) UPF0242 PF06785.11 ETO10693.1 - 1.3 9.1 26.9 0.27 11.3 22.6 2.0 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus NPV_P10 PF05531.12 ETO10693.1 - 1.5 9.3 9.7 4.2 7.9 3.9 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein CENP-Q PF13094.6 ETO10693.1 - 5.1 7.3 12.8 1.2 9.3 4.1 2.6 2 1 1 3 3 3 0 CENP-Q, a CENPA-CAD centromere complex subunit SpecificRecomb PF10136.9 ETO10693.1 - 8 4.6 7.9 3.2 6.0 2.3 1.9 1 1 1 2 2 2 0 Site-specific recombinase Kelch_6 PF13964.6 ETO10694.1 - 0.0056 16.9 2.2 1.8 9.0 0.0 3.7 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO10694.1 - 0.013 15.4 1.9 3.9 7.6 0.0 4.7 5 0 0 5 5 5 0 Kelch motif Kelch_5 PF13854.6 ETO10694.1 - 0.11 12.5 3.5 1 9.4 0.0 3.5 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO10695.1 - 2.3e-38 129.5 33.8 1.6e-06 28.7 1.0 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10695.1 - 3.2e-12 46.6 5.2 0.048 14.0 0.0 6.0 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10695.1 - 7.5e-09 34.8 8.7 0.084 11.5 1.6 5.0 2 2 0 4 4 4 3 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO10695.1 - 0.0017 18.6 11.8 0.026 14.8 0.2 5.1 5 0 0 5 5 5 1 Kelch motif DUF5074 PF16819.5 ETO10695.1 - 0.071 13.2 0.9 18 5.4 0.1 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF5074) PH PF00169.29 ETO10696.1 - 0.0026 18.2 0.3 3 8.4 0.1 2.2 2 0 0 2 2 2 2 PH domain CheF-arch PF04283.12 ETO10696.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 Chemotaxis signal transduction system protein F from archaea Neur_chan_memb PF02932.16 ETO10697.1 - 1.8e-06 28.2 7.3 1.8e-06 28.2 7.3 3.5 3 1 1 4 4 4 1 Neurotransmitter-gated ion-channel transmembrane region DUF2070 PF09843.9 ETO10697.1 - 0.011 14.1 10.0 0.014 13.7 10.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Zip PF02535.22 ETO10697.1 - 0.092 11.9 1.2 0.15 11.2 1.2 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO10697.1 - 1.4 7.1 14.6 4 5.6 11.6 2.0 2 0 0 2 2 2 0 CDC45-like protein DUF4260 PF14079.6 ETO10697.1 - 1.7 8.7 5.0 0.44 10.5 1.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4260) RNA12 PF10443.9 ETO10697.1 - 2.1 6.9 8.7 4.1 6.0 8.7 1.3 1 0 0 1 1 1 0 RNA12 protein CPSF100_C PF13299.6 ETO10697.1 - 3.7 7.7 10.6 2.8 8.1 7.2 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ETO10697.1 - 4.7 6.9 11.4 8 6.1 10.0 2.0 2 0 0 2 2 2 0 Connexin GEN1_C PF18380.1 ETO10697.1 - 4.8 8.1 13.7 3.2 8.7 9.6 2.3 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain FAM176 PF14851.6 ETO10697.1 - 5 6.8 12.4 3.6 7.3 7.8 2.3 2 0 0 2 2 2 0 FAM176 family Saw1 PF11561.8 ETO10697.1 - 6.3 6.3 10.4 10 5.6 10.4 1.3 1 0 0 1 1 1 0 Single strand annealing-weakened 1 Tim54 PF11711.8 ETO10697.1 - 6.7 5.4 15.2 3.7 6.2 11.0 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF4637 PF15470.6 ETO10697.1 - 7.5 6.3 13.3 1e+02 2.6 13.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) GCD14 PF08704.10 ETO10697.1 - 9.7 5.8 9.6 9.6 5.8 0.0 2.2 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit RCC1 PF00415.18 ETO10699.1 - 3.6e-21 75.5 0.3 0.00079 20.0 0.0 7.1 7 1 0 7 7 7 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO10699.1 - 0.014 15.2 12.8 0.016 15.0 0.1 4.3 4 0 0 4 4 4 0 Regulator of chromosome condensation (RCC1) repeat Tristanin_u2 PF16638.5 ETO10699.1 - 0.044 14.6 3.1 0.075 13.9 3.1 1.3 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers SQS_PSY PF00494.19 ETO10702.1 - 0.00078 19.0 0.0 0.0013 18.3 0.0 1.3 1 0 0 1 1 1 1 Squalene/phytoene synthase TUTF7_u4 PF16631.5 ETO10702.1 - 0.083 13.5 7.9 0.19 12.4 7.9 1.6 1 0 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 GDI PF00996.18 ETO10703.1 - 5.2e-36 124.1 6.2 4.5e-17 61.7 1.9 3.5 3 1 1 4 4 4 3 GDP dissociation inhibitor GTP_EFTU PF00009.27 ETO10705.1 - 8.4e-26 90.7 0.0 9.3e-26 90.6 0.0 1.0 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO10705.1 - 5.7e-06 26.4 0.1 1.7e-05 24.9 0.1 1.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETO10705.1 - 0.0053 16.8 1.5 0.97 9.5 0.9 2.3 1 1 1 2 2 2 2 Dynamin family RsgA_GTPase PF03193.16 ETO10705.1 - 0.0081 16.1 1.5 0.064 13.2 0.5 2.4 1 1 1 2 2 2 1 RsgA GTPase Zeta_toxin PF06414.12 ETO10705.1 - 0.011 15.0 0.4 0.056 12.7 0.1 2.1 2 1 1 3 3 3 0 Zeta toxin PduV-EutP PF10662.9 ETO10705.1 - 0.021 14.6 0.1 4.8 6.9 0.0 2.2 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Septin PF00735.18 ETO10705.1 - 0.027 13.8 0.0 0.07 12.4 0.0 1.6 1 1 0 1 1 1 0 Septin AAA_22 PF13401.6 ETO10705.1 - 0.032 14.5 0.1 0.038 14.3 0.1 1.4 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO10705.1 - 0.032 14.4 0.0 0.046 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain cobW PF02492.19 ETO10705.1 - 0.037 13.6 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 ETO10705.1 - 0.053 13.0 0.1 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_18 PF13238.6 ETO10705.1 - 0.058 13.9 0.0 0.086 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain dNK PF01712.19 ETO10705.1 - 0.067 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase ABC_tran PF00005.27 ETO10705.1 - 0.14 12.7 0.1 0.21 12.1 0.1 1.5 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ETO10705.1 - 0.17 11.6 0.0 0.4 10.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 ETO10709.1 - 6.1e-10 39.5 0.4 1.6e-06 28.7 0.2 4.1 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10709.1 - 0.00022 21.5 0.0 0.019 15.2 0.0 2.8 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain RCC1_2 PF13540.6 ETO10709.1 - 0.053 13.3 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat Sporozoite_P67 PF05642.11 ETO10709.1 - 0.17 10.0 11.5 0.25 9.4 11.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RNase_H PF00075.24 ETO10710.1 - 7.1e-08 32.7 0.0 1.4e-07 31.8 0.0 1.5 1 1 0 1 1 1 1 RNase H DUF3481 PF11980.8 ETO10710.1 - 0.041 13.6 0.0 0.069 12.9 0.0 1.2 1 0 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein SapB_1 PF05184.15 ETO10710.1 - 0.066 13.2 1.1 32 4.7 0.2 3.8 4 0 0 4 4 4 0 Saposin-like type B, region 1 ANAPC4_WD40 PF12894.7 ETO10711.1 - 5.9e-07 29.7 0.0 0.3 11.4 0.0 4.8 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO10711.1 - 2.2e-06 28.3 0.5 0.023 15.6 0.0 5.2 6 0 0 6 6 6 1 WD domain, G-beta repeat PD40 PF07676.12 ETO10711.1 - 3e-06 27.0 5.8 0.065 13.2 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO10711.1 - 0.013 14.1 0.1 1 7.8 0.0 2.9 2 1 1 3 3 3 0 Cytochrome D1 heme domain MBT PF02820.18 ETO10713.1 - 0.0045 17.3 0.2 0.017 15.4 0.0 2.0 2 1 0 2 2 2 1 mbt repeat ERp29 PF07749.12 ETO10714.1 - 2.3e-22 79.7 1.8 4.5e-22 78.7 1.8 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain ERp29_N PF07912.13 ETO10714.1 - 6.3e-16 58.7 0.9 1.5e-15 57.5 0.1 1.9 2 0 0 2 2 2 1 ERp29, N-terminal domain ssDNA_DBD PF18333.1 ETO10714.1 - 0.0028 17.7 0.1 0.0059 16.7 0.1 1.5 1 0 0 1 1 1 1 Non-canonical single-stranded DNA-binding domain IZUMO PF15005.6 ETO10714.1 - 0.0052 17.3 2.2 0.0099 16.4 2.2 1.5 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated RapA_C PF12137.8 ETO10714.1 - 0.0056 15.7 0.1 0.007 15.4 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase recycling family C-terminal Reovirus_Mu2 PF07781.11 ETO10714.1 - 0.027 12.8 0.0 0.035 12.5 0.0 1.1 1 0 0 1 1 1 0 Reovirus minor core protein Mu-2 Mito_carr PF00153.27 ETO10715.1 - 8.4e-23 80.1 0.4 1.3e-13 50.7 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF5352 PF17303.2 ETO10716.1 - 0.26 11.1 2.5 0.36 10.7 2.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5352) Neur_chan_memb PF02932.16 ETO10716.1 - 0.95 9.5 3.8 1.1 9.2 3.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region adh_short PF00106.25 ETO10717.1 - 7.9e-41 139.7 0.1 9.5e-41 139.4 0.1 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO10717.1 - 5.9e-34 117.6 0.0 6.8e-34 117.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO10717.1 - 1e-05 25.6 0.0 1.3e-05 25.2 0.0 1.1 1 0 0 1 1 1 1 KR domain DUF1959 PF09218.10 ETO10717.1 - 0.023 14.8 0.1 0.043 13.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) EBV-NA1 PF02905.14 ETO10717.1 - 0.11 12.3 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Epstein Barr virus nuclear antigen-1, DNA-binding domain TFIIS_M PF07500.14 ETO10718.1 - 4.5e-16 59.3 3.4 7.2e-16 58.7 3.4 1.4 1 0 0 1 1 1 1 Transcription factor S-II (TFIIS), central domain Telomerase_RBD PF12009.8 ETO10718.1 - 0.0099 16.0 5.3 0.016 15.3 5.3 1.4 1 0 0 1 1 1 1 Telomerase ribonucleoprotein complex - RNA binding domain Med26 PF08711.11 ETO10719.1 - 3.8e-13 49.2 0.2 9.8e-13 47.9 0.2 1.7 1 0 0 1 1 1 1 TFIIS helical bundle-like domain DUF2795 PF11387.8 ETO10719.1 - 0.13 12.5 0.1 0.41 10.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2795) DUF4636 PF15468.6 ETO10720.1 - 0.005 16.6 0.3 0.0062 16.3 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4636) Nodulin_late PF07127.11 ETO10720.1 - 0.041 14.2 4.0 0.43 11.0 0.1 2.3 2 0 0 2 2 2 0 Late nodulin protein V-SNARE_C PF12352.8 ETO10722.1 - 4.1e-05 23.8 4.5 4.1e-05 23.8 4.5 2.0 2 1 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO10722.1 - 0.0003 20.7 3.8 0.00036 20.4 0.2 2.7 2 1 2 4 4 4 1 Sec20 DUF3829 PF12889.7 ETO10722.1 - 0.022 14.2 1.8 0.03 13.8 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3829) TcdB_N PF12918.7 ETO10722.1 - 0.21 11.9 4.2 0.5 10.7 2.8 2.3 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain V-SNARE PF05008.15 ETO10722.1 - 0.23 11.9 5.3 0.058 13.8 1.7 2.0 2 1 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF3439 PF11921.8 ETO10723.1 - 0.31 11.0 17.7 0.5 10.4 3.3 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF4064 PF13273.6 ETO10724.1 - 0.012 15.9 4.0 1.6 9.0 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Tetraspanin PF00335.20 ETO10724.1 - 0.17 11.5 4.9 0.076 12.7 1.3 2.1 2 0 0 2 2 2 0 Tetraspanin family DUF1673 PF07895.11 ETO10724.1 - 2.1 8.0 14.4 0.67 9.6 10.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1673) EF-hand_7 PF13499.6 ETO10725.1 - 1.2e-09 38.4 1.5 0.00044 20.6 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO10725.1 - 4.9e-09 35.9 0.5 0.0033 17.2 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO10725.1 - 1.2e-08 34.2 1.3 0.02 14.8 0.2 3.9 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 ETO10725.1 - 5.1e-06 25.7 6.6 0.023 14.2 0.7 3.5 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 ETO10725.1 - 1.5e-05 25.3 1.4 0.0021 18.3 0.1 2.5 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO10725.1 - 0.00014 21.2 0.6 0.011 15.1 0.0 3.0 3 0 0 3 3 3 1 EF hand EF-hand_4 PF12763.7 ETO10725.1 - 0.00026 20.9 0.4 0.014 15.4 0.1 2.2 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand LTXXQ PF07813.12 ETO10725.1 - 0.0024 18.6 0.8 0.0035 18.0 0.1 1.6 2 0 0 2 2 2 1 LTXXQ motif family protein EF-hand_9 PF14658.6 ETO10725.1 - 0.0093 16.3 0.1 0.12 12.8 0.0 2.4 2 1 0 2 2 2 1 EF-hand domain Toprim_2 PF13155.6 ETO10725.1 - 0.045 14.2 0.2 0.082 13.3 0.2 1.4 1 0 0 1 1 1 0 Toprim-like HEAT PF02985.22 ETO10727.1 - 0.00052 20.0 0.3 1.1 9.7 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ETO10727.1 - 0.027 15.0 0.0 5.6 7.6 0.0 2.9 4 0 0 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 ETO10727.1 - 0.031 14.7 0.0 8.2 6.9 0.0 2.4 1 1 0 2 2 2 0 HEAT repeats LapD_MoxY_N PF16448.5 ETO10727.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain COX7a PF02238.15 ETO10730.1 - 0.15 12.5 2.7 0.16 12.3 0.8 2.1 1 1 1 2 2 2 0 Cytochrome c oxidase subunit VII YbgS PF13985.6 ETO10730.1 - 0.25 11.6 2.3 0.35 11.2 2.3 1.2 1 0 0 1 1 1 0 YbgS-like protein TraT PF05818.12 ETO10730.1 - 0.38 10.4 4.1 0.49 10.0 4.1 1.2 1 0 0 1 1 1 0 Enterobacterial TraT complement resistance protein Tic110 PF16940.5 ETO10730.1 - 5.7 5.3 5.7 6.4 5.1 5.7 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter TMEM51 PF15345.6 ETO10732.1 - 0.066 13.0 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 LAGLIDADG_1 PF00961.19 ETO10733.1 - 0.015 16.2 3.5 0.19 12.7 3.5 2.1 1 1 0 1 1 1 0 LAGLIDADG endonuclease C1_4 PF07975.12 ETO10734.1 - 0.018 15.3 0.1 0.047 13.9 0.1 1.7 1 0 0 1 1 1 0 TFIIH C1-like domain zf-C2H2 PF00096.26 ETO10734.1 - 0.035 14.6 0.0 0.096 13.2 0.0 1.8 1 0 0 1 1 1 0 Zinc finger, C2H2 type Pep3_Vps18 PF05131.14 ETO10734.1 - 0.068 13.0 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 Pep3/Vps18/deep orange family Tox-PLDMTX PF15645.6 ETO10734.1 - 0.11 12.8 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold RNA_pol_Rpb5_C PF01191.19 ETO10734.1 - 0.12 12.3 0.0 1.1 9.1 0.0 2.2 1 1 1 2 2 2 0 RNA polymerase Rpb5, C-terminal domain Mur_ligase_C PF02875.21 ETO10738.1 - 0.001 19.3 0.0 0.0023 18.2 0.0 1.6 1 0 0 1 1 1 1 Mur ligase family, glutamate ligase domain Peptidase_C14 PF00656.22 ETO10739.1 - 4.5e-16 59.6 1.7 8.2e-16 58.7 1.7 1.3 1 0 0 1 1 1 1 Caspase domain Phage_int_SAM_4 PF13495.6 ETO10739.1 - 0.0021 18.5 0.2 0.0045 17.4 0.2 1.5 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain NblA PF04485.12 ETO10739.1 - 0.041 14.3 0.4 0.041 14.3 0.4 2.1 2 0 0 2 2 2 0 Phycobilisome degradation protein nblA TPR_12 PF13424.6 ETO10740.1 - 4.5e-66 219.1 25.4 3.7e-20 72.0 1.0 4.7 1 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO10740.1 - 7.2e-58 191.0 5.5 2.4e-11 43.1 0.1 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10740.1 - 8.2e-49 161.5 45.1 2e-08 33.7 0.4 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10740.1 - 8.8e-47 153.8 16.1 2.3e-07 30.4 0.0 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO10740.1 - 1e-33 112.7 32.7 3.2e-06 26.8 1.1 7.0 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10740.1 - 3.5e-33 111.0 46.1 4.3e-07 29.6 0.5 7.9 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10740.1 - 8.8e-19 66.9 39.3 3.7e-05 23.3 0.5 8.6 6 2 2 8 8 8 6 TPR repeat TPR_14 PF13428.6 ETO10740.1 - 1e-16 60.2 0.2 0.65 11.0 0.0 6.6 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO10740.1 - 1.2e-12 47.3 18.8 0.089 13.2 0.2 7.4 7 1 0 7 7 5 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO10740.1 - 2.8e-12 46.4 7.6 0.18 12.5 0.2 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO10740.1 - 1.1e-11 44.8 15.4 0.18 11.6 0.2 6.6 6 1 1 7 7 7 4 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETO10740.1 - 7.2e-11 42.6 0.3 0.36 11.5 0.0 5.5 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO10740.1 - 6.8e-10 38.8 0.0 4.1e-06 26.4 0.0 2.6 1 1 2 3 3 3 2 MalT-like TPR region DUF2225 PF09986.9 ETO10740.1 - 1.1e-05 25.3 17.3 0.019 14.7 0.7 3.4 2 1 1 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) SHNi-TPR PF10516.9 ETO10740.1 - 1.9e-05 24.0 5.7 3.8 7.0 0.2 5.9 6 0 0 6 6 6 1 SHNi-TPR Fis1_TPR_C PF14853.6 ETO10740.1 - 5.6e-05 23.1 24.8 0.031 14.4 0.4 6.0 6 0 0 6 6 6 2 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETO10740.1 - 0.00018 21.9 5.1 4.1 8.0 0.3 4.5 3 1 2 5 5 5 1 Tetratricopeptide repeat PPR PF01535.20 ETO10740.1 - 0.00029 20.9 9.1 0.56 10.6 0.0 5.8 6 0 0 6 6 5 1 PPR repeat MIT PF04212.18 ETO10740.1 - 0.0015 18.6 34.8 0.71 10.0 0.6 7.2 8 0 0 8 8 6 2 MIT (microtubule interacting and transport) domain HTH_Bact PF18768.1 ETO10740.1 - 0.0033 17.0 21.8 9.8 5.9 1.1 8.0 6 1 1 7 7 6 0 Helix-turn-helix bacterial domain ANAPC3 PF12895.7 ETO10740.1 - 0.0062 16.7 13.9 0.85 9.9 0.2 4.8 2 2 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF3856 PF12968.7 ETO10740.1 - 0.0065 16.6 5.6 3.1 7.9 0.4 4.0 1 1 4 5 5 5 3 Domain of Unknown Function (DUF3856) SPO22 PF08631.10 ETO10740.1 - 0.021 14.3 18.0 1.1 8.7 4.0 5.1 2 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like RPN7 PF10602.9 ETO10740.1 - 0.022 14.5 16.0 1.6 8.4 2.4 4.5 2 1 2 4 4 4 0 26S proteasome subunit RPN7 TPR_3 PF07720.12 ETO10740.1 - 0.024 14.7 33.1 1.5 8.9 0.1 6.7 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF5051 PF16473.5 ETO10740.1 - 0.03 14.3 2.1 0.042 13.8 0.6 2.0 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like Sel1 PF08238.12 ETO10740.1 - 0.031 15.0 14.1 18 6.2 0.6 6.5 6 1 0 6 6 6 0 Sel1 repeat Ten1_2 PF15490.6 ETO10740.1 - 0.033 13.9 0.1 35 4.1 0.0 3.6 2 1 0 3 3 3 0 Telomere-capping, CST complex subunit DUF627 PF04781.12 ETO10740.1 - 0.034 14.2 10.1 0.8 9.7 0.6 5.1 3 2 0 3 3 3 0 Protein of unknown function (DUF627) DUF2977 PF11192.8 ETO10740.1 - 0.069 13.3 0.0 23 5.2 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2977) SMBP PF16785.5 ETO10740.1 - 0.22 11.7 5.1 2.5 8.3 0.2 3.4 3 1 0 3 3 2 0 Small metal-binding protein DUF3450 PF11932.8 ETO10740.1 - 0.43 9.8 5.5 0.44 9.8 0.4 3.3 3 1 0 4 4 4 0 Protein of unknown function (DUF3450) Phage_Treg PF04761.12 ETO10740.1 - 3 8.0 9.6 24 5.1 0.0 4.6 6 1 1 7 7 4 0 Lactococcus bacteriophage putative transcription regulator Sda PF08970.10 ETO10740.1 - 4.3 7.2 9.1 18 5.1 0.2 4.5 5 0 0 5 5 5 0 Sporulation inhibitor A WD40 PF00400.32 ETO10741.1 - 5e-10 39.8 4.3 0.001 19.9 0.2 3.7 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10741.1 - 0.0068 16.7 0.1 2 8.8 0.1 2.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10741.1 - 0.0068 15.1 0.1 0.64 8.6 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 RPEL PF02755.15 ETO10742.1 - 5.1e-06 26.0 23.1 2.1e-05 24.0 1.7 6.1 6 1 0 6 6 6 2 RPEL repeat HYLS1_C PF15311.6 ETO10742.1 - 0.072 13.8 0.3 0.072 13.8 0.3 3.2 4 0 0 4 4 4 0 Hydrolethalus syndrome protein 1 C-terminus DUF883 PF05957.13 ETO10742.1 - 0.79 10.4 0.0 0.79 10.4 0.0 3.3 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) RPEL PF02755.15 ETO10743.1 - 9.6e-09 34.7 10.6 0.0018 17.9 0.7 5.6 5 0 0 5 5 5 3 RPEL repeat Urm1 PF09138.11 ETO10743.1 - 0.055 13.8 0.0 0.46 10.9 0.0 2.5 1 1 0 1 1 1 0 Urm1 (Ubiquitin related modifier) DUF3653 PF12375.8 ETO10744.1 - 0.13 12.4 0.2 0.73 10.0 0.0 2.2 2 1 0 2 2 2 0 Phage protein Xin PF08043.12 ETO10744.1 - 0.18 11.5 0.5 21 5.0 0.0 2.4 2 0 0 2 2 2 0 Xin repeat Ctr PF04145.15 ETO10744.1 - 0.24 12.0 3.7 0.29 11.7 3.7 1.2 1 0 0 1 1 1 0 Ctr copper transporter family Orf78 PF06024.12 ETO10744.1 - 1.6 9.1 5.4 3.6 7.9 2.4 2.2 2 0 0 2 2 2 0 Orf78 (ac78) PARP PF00644.20 ETO10745.1 - 0.048 13.2 0.2 0.11 12.1 0.2 1.5 1 0 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain G-alpha PF00503.20 ETO10746.1 - 1e-22 80.8 0.4 1.3e-22 80.4 0.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_18 PF13238.6 ETO10746.1 - 0.0042 17.6 0.0 0.0089 16.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ETO10746.1 - 0.017 15.2 0.0 0.027 14.5 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase Arf PF00025.21 ETO10746.1 - 0.042 13.3 0.0 0.063 12.7 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family ABC_tran PF00005.27 ETO10746.1 - 0.076 13.5 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 ABC transporter RNA_pol_Rpb1_3 PF04983.18 ETO10746.1 - 0.1 12.5 0.1 0.3 11.0 0.0 1.8 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 3 AAA_28 PF13521.6 ETO10746.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO10746.1 - 0.13 12.1 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DpnI_C PF17726.1 ETO10747.1 - 0.04 14.1 0.0 0.076 13.2 0.0 1.4 1 0 0 1 1 1 0 Dam-replacing HTH domain AhpC-TSA PF00578.21 ETO10748.1 - 0.035 14.0 0.0 0.078 12.9 0.0 1.5 2 0 0 2 2 2 0 AhpC/TSA family DUF2666 PF10869.8 ETO10749.1 - 0.017 15.3 0.1 0.051 13.8 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2666) AAA_7 PF12775.7 ETO10749.1 - 0.026 14.1 0.1 2.8 7.4 0.0 3.2 2 1 1 3 3 3 0 P-loop containing dynein motor region AAA_22 PF13401.6 ETO10749.1 - 0.038 14.3 0.1 0.62 10.3 0.0 2.7 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ETO10749.1 - 0.046 13.6 0.1 5.1 7.0 0.0 2.6 2 0 0 2 2 2 0 NTPase Pox_E10 PF04805.12 ETO10749.1 - 0.066 13.1 0.3 0.24 11.3 0.1 2.0 2 0 0 2 2 2 0 E10-like protein conserved region AAA PF00004.29 ETO10749.1 - 0.11 12.9 0.0 0.38 11.2 0.0 2.0 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Malic_M PF03949.15 ETO10750.1 - 2e-27 96.1 0.1 2.6e-27 95.7 0.1 1.1 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain DUF3695 PF12494.8 ETO10750.1 - 0.077 12.9 0.1 0.12 12.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3695) NAAA-beta PF15508.6 ETO10751.1 - 8.8e-14 51.6 0.2 1.4e-13 50.9 0.2 1.3 1 0 0 1 1 1 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.18 ETO10751.1 - 0.00077 19.2 0.0 0.0011 18.7 0.0 1.2 1 0 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family Zip PF02535.22 ETO10753.1 - 0.00014 21.2 0.9 0.00017 21.0 0.9 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter V_ATPase_I PF01496.19 ETO10753.1 - 0.0033 15.4 4.7 0.0038 15.2 4.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4199 PF13858.6 ETO10753.1 - 0.0044 17.4 0.0 0.069 13.6 0.0 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF4199) DUF2956 PF11169.8 ETO10753.1 - 0.0062 16.7 4.1 0.0062 16.7 4.1 2.1 1 1 1 2 2 1 1 Protein of unknown function (DUF2956) Peroxin-13_N PF04088.13 ETO10753.1 - 0.0062 16.8 0.5 0.0062 16.8 0.5 2.0 1 1 1 2 2 2 1 Peroxin 13, N-terminal region Ctr PF04145.15 ETO10753.1 - 0.011 16.3 0.1 0.015 16.0 0.1 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Vfa1 PF08432.10 ETO10753.1 - 0.014 15.8 15.9 0.017 15.5 15.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO10753.1 - 0.017 14.9 10.3 0.042 13.6 10.3 1.6 1 1 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO10753.1 - 0.018 13.8 4.5 0.022 13.6 4.5 1.2 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 ETO10753.1 - 0.019 13.4 2.8 0.021 13.2 2.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SpoIIP PF07454.11 ETO10753.1 - 0.022 14.2 9.5 0.028 13.9 9.5 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CLN3 PF02487.17 ETO10753.1 - 0.028 13.5 1.1 0.034 13.2 1.1 1.1 1 0 0 1 1 1 0 CLN3 protein DAG_kinase_N PF14513.6 ETO10753.1 - 0.029 14.6 6.8 0.036 14.3 6.8 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Mem_trans PF03547.18 ETO10753.1 - 0.058 11.8 0.7 0.062 11.7 0.7 1.0 1 0 0 1 1 1 0 Membrane transport protein Neur_chan_memb PF02932.16 ETO10753.1 - 0.079 13.0 1.8 0.089 12.8 1.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HCO3_cotransp PF00955.21 ETO10753.1 - 0.08 11.7 1.3 0.092 11.6 1.3 1.0 1 0 0 1 1 1 0 HCO3- transporter family O-antigen_lig PF13425.6 ETO10753.1 - 0.093 11.5 5.7 0.1 11.3 5.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein ALMT PF11744.8 ETO10753.1 - 0.14 11.0 4.5 0.16 10.8 4.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Serinc PF03348.15 ETO10753.1 - 0.15 11.0 0.4 0.19 10.6 0.4 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) NPR3 PF03666.13 ETO10753.1 - 0.16 10.7 12.3 0.19 10.5 12.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vma12 PF11712.8 ETO10753.1 - 0.2 11.7 3.5 0.27 11.3 3.5 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase 7tm_1 PF00001.21 ETO10753.1 - 0.2 10.9 3.2 0.46 9.8 3.2 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Sec62 PF03839.16 ETO10753.1 - 0.22 11.0 17.6 0.3 10.6 17.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF4569 PF15133.6 ETO10753.1 - 0.25 11.1 7.8 0.28 10.8 7.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) PA26 PF04636.13 ETO10753.1 - 0.32 9.9 5.2 0.35 9.7 5.2 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2828 PF11443.8 ETO10753.1 - 0.34 9.0 9.9 0.38 8.8 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) LicD PF04991.13 ETO10753.1 - 0.83 9.7 11.2 0.96 9.5 11.2 1.0 1 0 0 1 1 1 0 LicD family CSG2 PF16965.5 ETO10753.1 - 1 8.3 4.1 1.5 7.6 4.1 1.4 1 1 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 ETO10753.1 - 2 8.2 18.0 2.5 7.9 18.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 OATP PF03137.20 ETO10753.1 - 3.2 5.9 8.7 8 4.6 8.7 1.6 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF1168 PF06658.12 ETO10753.1 - 3.5 7.4 34.8 4.7 7.0 34.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) AAA_11 PF13086.6 ETO10753.1 - 4.7 6.9 14.7 5.8 6.6 14.7 1.0 1 0 0 1 1 1 0 AAA domain DUF3987 PF13148.6 ETO10753.1 - 5.8 5.8 10.3 6.9 5.6 10.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Orf78 PF06024.12 ETO10753.1 - 6.3 7.2 12.8 2.3e+02 2.2 11.8 2.4 1 1 1 2 2 1 0 Orf78 (ac78) MCM_bind PF09739.9 ETO10753.1 - 7.5 4.9 13.2 9.3 4.6 13.2 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Tim54 PF11711.8 ETO10755.1 - 6.2e-05 22.0 6.1 8.2e-05 21.5 6.1 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 ETO10755.1 - 0.0014 17.6 7.0 0.0016 17.3 7.0 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 LMBR1 PF04791.16 ETO10755.1 - 0.0016 17.5 0.7 0.0017 17.4 0.7 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein SID-1_RNA_chan PF13965.6 ETO10755.1 - 0.0043 15.5 0.4 0.0052 15.3 0.4 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Zip PF02535.22 ETO10755.1 - 0.0055 16.0 0.0 0.0055 16.0 0.0 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter DUF2058 PF09831.9 ETO10755.1 - 0.01 16.0 12.3 0.012 15.8 12.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) DUF2126 PF09899.9 ETO10755.1 - 0.02 13.0 0.7 0.031 12.4 0.7 1.2 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) AF-4 PF05110.13 ETO10755.1 - 0.025 12.7 12.8 0.026 12.7 12.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FancD2 PF14631.6 ETO10755.1 - 0.041 11.3 5.0 0.046 11.1 5.0 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease AAA_13 PF13166.6 ETO10755.1 - 0.11 11.1 14.8 0.14 10.8 14.8 1.1 1 0 0 1 1 1 0 AAA domain SUFU_C PF12470.8 ETO10755.1 - 0.12 12.4 3.8 0.18 11.8 3.8 1.2 1 0 0 1 1 1 0 Suppressor of Fused Gli/Ci N terminal binding domain ALMT PF11744.8 ETO10755.1 - 0.29 9.9 6.3 0.4 9.5 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RPN2_C PF18004.1 ETO10755.1 - 2.5 8.0 24.5 4 7.3 24.5 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Vfa1 PF08432.10 ETO10755.1 - 3 8.1 26.9 5 7.4 26.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 AAA_11 PF13086.6 ETO10755.1 - 3.5 7.3 14.2 5.2 6.8 14.2 1.2 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 ETO10755.1 - 3.8 6.2 10.6 6.3 5.5 10.6 1.3 1 0 0 1 1 1 0 Presenilin MCM_bind PF09739.9 ETO10755.1 - 3.8 5.8 12.0 4.9 5.5 12.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor PIEZO PF15917.5 ETO10755.1 - 5.7 6.4 20.3 8.9 5.7 20.3 1.3 1 0 0 1 1 1 0 Piezo DUF3807 PF12720.7 ETO10755.1 - 5.7 7.2 21.2 9.6 6.4 21.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Melibiase_2 PF16499.5 ETO10756.1 - 5.2e-25 88.2 0.5 7.6e-19 68.0 0.1 2.5 1 1 1 2 2 2 2 Alpha galactosidase A Melibiase_C PF17801.1 ETO10756.1 - 2.2e-10 40.4 1.2 5.1e-10 39.3 1.2 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain OPA3 PF07047.12 ETO10758.1 - 3.1e-09 36.7 0.9 4.6e-09 36.1 0.1 1.7 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) Vps5 PF09325.10 ETO10758.1 - 0.03 13.9 1.4 0.053 13.1 0.1 1.9 2 0 0 2 2 2 0 Vps5 C terminal like DUF4349 PF14257.6 ETO10758.1 - 0.063 12.7 1.6 1.6 8.2 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) CdvA PF18822.1 ETO10758.1 - 0.07 13.0 2.6 7.4 6.4 0.8 2.3 2 0 0 2 2 2 0 CdvA-like coiled-coil domain DinB_2 PF12867.7 ETO10758.1 - 0.15 12.6 0.0 0.27 11.7 0.0 1.7 1 1 0 1 1 1 0 DinB superfamily DivIC PF04977.15 ETO10758.1 - 0.18 11.6 8.1 4.7 7.1 0.9 3.7 3 1 0 3 3 3 0 Septum formation initiator KELK PF15796.5 ETO10758.1 - 0.48 10.9 4.8 0.47 11.0 0.8 2.6 3 0 0 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FlxA PF14282.6 ETO10758.1 - 0.58 10.2 15.5 0.16 12.0 1.3 2.7 2 1 0 2 2 2 0 FlxA-like protein SlyX PF04102.12 ETO10758.1 - 0.66 10.6 4.6 4.5 8.0 0.1 2.7 3 0 0 3 3 3 0 SlyX Csm1_N PF18504.1 ETO10758.1 - 1.1 9.6 7.7 4.2 7.8 0.1 2.7 3 0 0 3 3 3 0 Csm1 N-terminal domain HC2 PF07382.11 ETO10759.1 - 2e-07 31.3 34.0 3.2e-07 30.6 34.0 1.3 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 ASFV_J13L PF05568.11 ETO10759.1 - 1e-05 25.4 13.2 0.0016 18.3 4.5 2.4 1 1 1 2 2 2 2 African swine fever virus J13L protein XPG_I PF00867.18 ETO10760.1 - 2.1e-28 98.5 1.4 2.4e-28 98.3 0.1 1.8 2 0 0 2 2 2 1 XPG I-region 5_3_exonuc PF01367.20 ETO10760.1 - 2.7e-09 37.5 0.3 9e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 5'-3' exonuclease, C-terminal SAM fold XPG_N PF00752.17 ETO10760.1 - 2.9e-07 30.9 0.0 7.5e-07 29.6 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain Fe_dep_repr_C PF02742.15 ETO10760.1 - 0.028 14.5 0.0 52 4.0 0.0 3.3 3 0 0 3 3 3 0 Iron dependent repressor, metal binding and dimerisation domain HHH_2 PF12826.7 ETO10760.1 - 0.028 14.5 0.0 0.077 13.1 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 ETO10760.1 - 0.036 14.7 0.0 0.094 13.3 0.0 1.7 1 0 0 1 1 1 0 Helix-hairpin-helix domain RRM_1 PF00076.22 ETO10761.1 - 1.2e-07 31.5 0.0 0.014 15.2 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Orf78 PF06024.12 ETO10761.1 - 0.032 14.5 0.2 0.071 13.4 0.1 1.6 2 0 0 2 2 2 0 Orf78 (ac78) RRM_1 PF00076.22 ETO10762.1 - 1.8e-09 37.3 1.0 0.041 13.7 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1644 PF07800.12 ETO10763.1 - 0.0019 18.3 9.9 0.0093 16.0 9.8 2.0 1 1 0 1 1 1 1 Protein of unknown function (DUF1644) DUF2452 PF10504.9 ETO10763.1 - 0.0054 16.2 1.7 0.0095 15.4 1.7 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2452) DEP PF00610.21 ETO10766.1 - 0.0018 18.3 0.0 0.0032 17.5 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PP2C PF00481.21 ETO10767.1 - 3.5e-11 43.2 0.1 1.6e-10 41.0 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C Calpain_u2 PF16648.5 ETO10767.1 - 0.094 13.2 2.2 1.3 9.6 2.5 2.4 2 0 0 2 2 2 0 Unstructured region on Calpain-3 DUF3827 PF12877.7 ETO10767.1 - 0.21 9.9 7.8 0.28 9.5 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Connexin PF00029.19 ETO10768.1 - 0.0037 17.0 0.3 0.004 17.0 0.3 1.0 1 0 0 1 1 1 1 Connexin RR_TM4-6 PF06459.12 ETO10768.1 - 0.0086 15.9 2.4 0.009 15.9 2.4 1.0 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 DUF2417 PF10329.9 ETO10768.1 - 0.0092 15.4 0.0 0.011 15.2 0.0 1.0 1 0 0 1 1 1 1 Region of unknown function (DUF2417) FAM176 PF14851.6 ETO10768.1 - 0.45 10.2 3.5 0.57 9.8 3.5 1.1 1 0 0 1 1 1 0 FAM176 family Exo_endo_phos_2 PF14529.6 ETO10771.1 - 2.2e-09 37.2 1.2 4.2e-09 36.3 0.3 1.9 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase zf-CCHC PF00098.23 ETO10771.1 - 0.0019 18.2 1.7 0.0019 18.2 1.7 2.7 2 0 0 2 2 2 1 Zinc knuckle HTH_36 PF13730.6 ETO10771.1 - 0.16 11.9 1.2 0.69 9.9 0.1 2.6 3 0 0 3 3 3 0 Helix-turn-helix domain Exo_endo_phos PF03372.23 ETO10771.1 - 0.18 11.3 0.0 0.3 10.6 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family WD40 PF00400.32 ETO10772.1 - 0.00069 20.4 2.9 0.0012 19.6 0.3 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Kelch_1 PF01344.25 ETO10773.1 - 2.9e-07 29.9 5.5 1.1e-05 24.9 0.4 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO10773.1 - 4.4e-06 26.5 1.1 0.00046 20.1 0.3 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO10773.1 - 0.00011 22.3 1.1 0.081 13.2 0.3 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO10773.1 - 0.00029 20.8 0.2 0.012 15.6 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO10773.1 - 0.0067 16.4 3.3 0.62 10.1 1.0 2.6 3 0 0 3 3 3 2 Kelch motif IL3Ra_N PF18611.1 ETO10773.1 - 0.022 14.7 0.2 0.04 13.9 0.2 1.3 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain Kelch_3 PF13415.6 ETO10773.1 - 0.029 14.7 0.3 2.2 8.7 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain APG5 PF04106.12 ETO10774.1 - 0.17 11.4 3.6 1 8.9 1.3 2.0 1 1 1 2 2 2 0 Autophagy protein Apg5 PUF PF00806.19 ETO10775.1 - 2.2e-28 96.3 4.4 8.6e-06 25.2 0.0 7.4 7 0 0 7 7 7 5 Pumilio-family RNA binding repeat CPL PF08144.11 ETO10775.1 - 0.001 19.4 2.8 1.5 9.2 0.1 4.4 1 1 3 5 5 5 2 CPL (NUC119) domain FIST_C PF10442.9 ETO10775.1 - 0.026 14.5 0.0 2.4 8.1 0.0 2.4 2 0 0 2 2 2 0 FIST C domain RVT_1 PF00078.27 ETO10777.1 - 0.018 14.6 0.0 0.023 14.2 0.0 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) Peptidase_C14 PF00656.22 ETO10778.1 - 2.2e-15 57.3 0.2 5e-15 56.1 0.2 1.5 1 0 0 1 1 1 1 Caspase domain WD40 PF00400.32 ETO10779.1 - 6.7e-15 55.2 10.3 3.6e-07 30.8 0.8 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat Sec62 PF03839.16 ETO10779.1 - 0.014 15.0 4.3 0.43 10.1 0.2 2.4 2 0 0 2 2 2 0 Translocation protein Sec62 ANAPC4_WD40 PF12894.7 ETO10779.1 - 0.015 15.6 0.1 9.1 6.7 0.0 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10779.1 - 0.085 11.5 0.2 6.8 5.2 0.1 2.4 1 1 0 2 2 2 0 Nucleoporin Nup120/160 PRKG1_interact PF15898.5 ETO10779.1 - 0.27 12.1 10.9 0.47 11.4 10.9 1.3 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain LCIB_C_CA PF18599.1 ETO10779.1 - 5 6.4 5.3 8.6 5.6 5.3 1.3 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Nuc_sug_transp PF04142.15 ETO10780.1 - 1.8e-10 40.5 10.5 2.3e-10 40.1 10.5 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ETO10780.1 - 1.7e-06 28.2 23.1 0.0026 17.9 0.9 2.2 2 0 0 2 2 2 2 EamA-like transporter family Ferlin_C PF16165.5 ETO10780.1 - 0.12 12.3 1.3 0.41 10.6 1.3 1.9 1 0 0 1 1 1 0 Ferlin C-terminus GWT1 PF06423.12 ETO10780.1 - 1.4 9.0 5.4 1 9.5 3.3 1.8 1 1 1 2 2 2 0 GWT1 DUF373 PF04123.13 ETO10780.1 - 9.6 5.5 9.5 28 4.0 9.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Ribosomal_L14 PF00238.19 ETO10781.1 - 5.1e-30 104.1 0.0 6e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Ribosomal protein L14p/L23e WD40 PF00400.32 ETO10785.1 - 4.8e-13 49.4 9.4 5.9e-06 26.9 0.3 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO10785.1 - 0.00019 20.2 1.5 0.00074 18.3 0.7 2.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO10785.1 - 0.0026 18.0 0.1 0.4 11.0 0.1 2.6 1 1 2 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO10785.1 - 0.0066 15.8 0.7 0.027 13.8 0.7 1.7 1 1 0 1 1 1 1 WD40-like domain DUF4221 PF13970.6 ETO10785.1 - 0.14 11.7 5.3 0.43 10.1 0.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Transcrip_reg PF01709.20 ETO10786.1 - 0.16 11.4 1.0 0.39 10.1 0.9 1.7 1 1 0 1 1 1 0 Transcriptional regulator COX5A PF02284.16 ETO10786.1 - 7.1 6.7 6.2 7.2 6.7 0.4 3.4 3 1 1 4 4 4 0 Cytochrome c oxidase subunit Va Pkinase PF00069.25 ETO10787.1 - 1.5e-36 126.2 0.4 2.7e-36 125.3 0.4 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10787.1 - 3.1e-18 66.0 0.0 3e-16 59.5 0.0 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 ETO10787.1 - 0.00017 21.0 0.1 0.00039 19.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO10787.1 - 0.0019 17.2 0.2 0.0022 17.0 0.2 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Mannosyl_trans3 PF11051.8 ETO10788.1 - 0.00028 20.3 0.1 0.00036 20.0 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 ETO10788.1 - 0.096 12.6 0.3 0.18 11.7 0.2 1.5 1 1 0 1 1 1 0 Nucleotide-diphospho-sugar transferase TMEMspv1-c74-12 PF11044.8 ETO10789.1 - 0.011 15.6 0.7 0.011 15.6 0.7 1.8 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF4710 PF15828.5 ETO10789.1 - 0.027 14.6 0.0 0.036 14.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) DUF2207 PF09972.9 ETO10789.1 - 2.1 7.0 4.1 2.4 6.8 4.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 ETO10793.1 - 1.7e-34 117.3 23.2 6.4e-08 33.1 0.9 6.1 5 2 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10793.1 - 2.5e-07 30.9 4.1 0.033 14.5 0.0 4.8 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10793.1 - 2.5e-07 29.7 6.6 0.67 8.5 0.0 4.9 2 1 3 5 5 5 5 Nucleoporin Nup120/160 LRR_4 PF12799.7 ETO10794.1 - 0.039 14.4 1.3 0.14 12.7 0.2 2.5 2 1 0 2 2 2 0 Leucine Rich repeats (2 copies) CPSF100_C PF13299.6 ETO10794.1 - 0.052 13.7 2.0 0.081 13.1 2.0 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 ETO10794.1 - 0.082 12.3 4.5 0.12 11.8 4.5 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SprA-related PF12118.8 ETO10794.1 - 1.7 7.7 9.2 2.4 7.2 9.2 1.2 1 0 0 1 1 1 0 SprA-related family DUF4175 PF13779.6 ETO10794.1 - 9 4.1 12.0 12 3.6 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Exo_endo_phos PF03372.23 ETO10795.1 - 3.5e-11 43.1 0.0 2.3e-10 40.4 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DDHD PF02862.17 ETO10795.1 - 0.025 14.7 0.4 0.029 14.5 0.4 1.2 1 0 0 1 1 1 0 DDHD domain DUF1280 PF06918.14 ETO10795.1 - 0.038 13.6 6.1 0.078 12.6 6.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) RNA_pol_Rpc4 PF05132.14 ETO10795.1 - 3 8.2 6.6 3.8 7.9 2.1 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 SBF2 PF12335.8 ETO10796.1 - 0.027 14.1 11.4 0.08 12.5 11.4 1.8 1 1 0 1 1 1 0 Myotubularin protein WD40 PF00400.32 ETO10798.1 - 2.2e-24 85.2 11.9 4.1e-05 24.3 0.1 5.8 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10798.1 - 8.4e-09 35.6 1.2 0.12 12.7 0.0 3.9 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10798.1 - 1.4e-06 27.3 4.5 0.44 9.1 0.1 4.0 1 1 2 4 4 4 4 Nucleoporin Nup120/160 DUF851 PF05867.11 ETO10798.1 - 0.085 12.3 0.0 0.2 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF851) WD40 PF00400.32 ETO10799.1 - 1.6e-38 130.0 20.6 2.9e-08 34.2 1.4 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10799.1 - 7.6e-12 45.4 6.2 0.022 15.0 0.0 6.4 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10799.1 - 6.5e-11 41.8 0.3 0.35 9.8 0.1 5.7 1 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO10799.1 - 1.2e-05 24.8 0.7 0.081 12.2 0.0 3.3 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO10799.1 - 0.00057 18.7 4.5 1.7 7.2 0.1 3.9 3 2 1 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO10799.1 - 0.0018 17.1 6.0 0.0081 14.9 1.2 3.0 2 2 0 2 2 2 1 Nup133 N terminal like DUF1652 PF07865.11 ETO10799.1 - 0.0071 16.2 0.1 2.7 7.9 0.0 3.7 3 1 0 3 3 3 1 Protein of unknown function (DUF1652) AviRa PF11599.8 ETO10799.1 - 0.14 11.6 0.0 0.26 10.7 0.0 1.4 1 0 0 1 1 1 0 RRNA methyltransferase AviRa PD40 PF07676.12 ETO10799.1 - 0.2 11.6 3.1 46 4.1 0.0 4.1 5 1 0 5 5 5 0 WD40-like Beta Propeller Repeat NB PF04159.13 ETO10800.1 - 0.05 13.6 1.1 0.089 12.8 0.9 1.5 1 1 0 1 1 1 0 NB glycoprotein WD40 PF00400.32 ETO10801.1 - 4.6e-18 65.3 11.8 2.8e-06 28.0 0.9 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO10801.1 - 1.1e-08 34.2 2.3 0.00034 19.4 0.2 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO10801.1 - 6.3e-06 26.4 0.5 0.15 12.4 0.1 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ABC2_membrane PF01061.24 ETO10802.1 - 2.2e-27 95.8 10.2 2.9e-27 95.5 10.2 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO10802.1 - 1.1e-05 24.7 6.6 1.2e-05 24.6 6.6 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein SNAP PF14938.6 ETO10803.1 - 3.6e-36 125.0 3.8 4.8e-36 124.6 3.8 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_2 PF07719.17 ETO10803.1 - 1.6e-06 27.8 6.2 0.0087 16.1 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO10803.1 - 3.1e-05 23.8 4.6 0.049 13.9 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO10803.1 - 0.00013 21.6 9.0 0.12 12.2 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO10803.1 - 0.0019 18.1 2.9 0.025 14.6 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO10803.1 - 0.011 16.0 1.1 0.053 13.8 0.3 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Clathrin PF00637.20 ETO10803.1 - 0.012 15.5 1.7 0.038 13.9 0.8 2.1 2 0 0 2 2 2 0 Region in Clathrin and VPS TPR_16 PF13432.6 ETO10803.1 - 0.021 15.5 1.1 0.21 12.2 0.4 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10803.1 - 0.033 13.9 12.8 0.35 10.6 0.4 3.7 4 0 0 4 4 4 0 TPR repeat TPR_12 PF13424.6 ETO10803.1 - 0.041 14.2 2.7 0.67 10.3 1.3 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat Mt_ATP-synt_B PF05405.14 ETO10803.1 - 0.073 12.7 0.0 0.18 11.4 0.0 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) VMR2 PF17055.5 ETO10803.1 - 0.098 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 Viral matrix protein M2 MerR-DNA-bind PF09278.11 ETO10803.1 - 0.1 13.2 0.9 0.17 12.4 0.4 1.7 2 0 0 2 2 1 0 MerR, DNA binding TPR_6 PF13174.6 ETO10803.1 - 0.59 10.9 5.2 31 5.5 0.1 3.7 4 0 0 4 4 3 0 Tetratricopeptide repeat NSF PF02071.20 ETO10803.1 - 2.8 9.1 6.3 97 4.5 0.3 3.9 3 2 1 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat MIT PF04212.18 ETO10803.1 - 3.2 7.9 7.9 14 5.8 0.3 3.3 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 ETO10803.1 - 4.4 7.3 5.0 8.2 6.4 0.2 3.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO10803.1 - 5.3 7.1 8.4 2.2 8.4 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO10805.1 - 2.2e-06 28.3 10.7 0.25 12.3 0.7 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10805.1 - 0.00033 20.9 1.5 0.22 11.8 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ERp29 PF07749.12 ETO10806.1 - 0.034 15.1 3.2 0.064 14.2 3.2 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain Mer2 PF09074.10 ETO10806.1 - 0.07 12.9 0.6 0.082 12.7 0.6 1.3 1 0 0 1 1 1 0 Mer2 MDM10 PF12519.8 ETO10806.1 - 0.71 8.7 5.0 0.85 8.4 5.0 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 WD40 PF00400.32 ETO10808.1 - 1e-50 168.6 23.9 1.4e-09 38.4 0.3 8.5 9 0 0 9 9 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10808.1 - 2.4e-16 59.8 6.3 0.11 12.8 0.0 7.7 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO10808.1 - 8.7e-13 48.6 3.9 1.8e-08 34.5 1.1 3.7 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO10808.1 - 1.1e-11 44.3 1.6 0.055 12.4 0.0 6.4 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO10808.1 - 4.8e-07 29.8 9.8 0.0038 17.5 0.0 5.9 7 0 0 7 7 5 2 Kelch motif Cytochrom_D1 PF02239.16 ETO10808.1 - 1.5e-05 23.7 0.6 0.071 11.6 0.1 3.7 3 1 0 3 3 3 1 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO10808.1 - 0.00031 19.6 0.1 0.51 9.0 0.0 2.7 1 1 0 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO10808.1 - 0.0016 18.3 1.8 12 5.9 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_4 PF13418.6 ETO10808.1 - 0.0017 18.3 2.9 0.57 10.2 0.1 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO10808.1 - 0.0036 17.5 0.2 0.042 14.1 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO10808.1 - 0.0085 15.3 0.1 2.6 7.1 0.0 2.3 2 0 0 2 2 2 2 Protein N-terminal asparagine amidohydrolase Kelch_1 PF01344.25 ETO10808.1 - 0.011 15.3 4.9 3.7 7.2 0.0 4.2 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO10808.1 - 0.12 12.4 3.0 19 5.4 0.1 4.2 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO10808.1 - 1.5 8.9 5.9 22 5.2 0.3 4.5 6 0 0 6 6 6 0 Kelch motif FlgN PF05130.12 ETO10809.1 - 0.0072 16.8 12.0 0.008 16.7 12.0 1.0 1 0 0 1 1 1 1 FlgN protein PRA-PH PF01503.17 ETO10809.1 - 0.021 15.2 0.5 0.021 15.2 0.5 1.5 2 0 0 2 2 1 0 Phosphoribosyl-ATP pyrophosphohydrolase CCDC144C PF14915.6 ETO10809.1 - 0.027 13.6 16.7 0.029 13.5 16.7 1.0 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region CHDCT2 PF08074.11 ETO10809.1 - 0.039 14.1 4.2 0.051 13.8 4.2 1.2 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain Atg14 PF10186.9 ETO10809.1 - 0.051 12.6 11.2 0.057 12.5 11.2 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CALCOCO1 PF07888.11 ETO10809.1 - 0.053 12.4 15.2 0.069 12.0 15.2 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like TipAS PF07739.13 ETO10809.1 - 0.099 13.2 8.0 0.64 10.6 8.0 1.9 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain DUF4200 PF13863.6 ETO10809.1 - 0.11 12.9 20.7 0.14 12.6 20.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) GAS PF13851.6 ETO10809.1 - 0.13 11.6 19.6 0.17 11.2 19.6 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF5388 PF17363.2 ETO10809.1 - 0.13 12.5 4.3 0.067 13.4 1.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5388) ATG16 PF08614.11 ETO10809.1 - 0.14 12.4 13.6 0.18 12.0 13.6 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) Ran-binding PF05508.11 ETO10809.1 - 0.15 11.1 5.4 0.17 10.9 5.4 1.1 1 0 0 1 1 1 0 RanGTP-binding protein SepSecS PF05889.13 ETO10809.1 - 0.15 10.8 3.7 0.15 10.7 3.7 1.1 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS DUF4618 PF15397.6 ETO10809.1 - 0.16 11.4 13.7 0.2 11.1 13.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Chordopox_A13L PF05961.11 ETO10809.1 - 0.17 12.2 1.9 0.24 11.7 0.7 1.8 1 1 1 2 2 2 0 Chordopoxvirus A13L protein DUF3450 PF11932.8 ETO10809.1 - 0.19 11.0 10.8 0.25 10.6 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF16 PF01519.16 ETO10809.1 - 0.19 12.3 11.6 1.2 9.6 11.6 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Het-C PF07217.11 ETO10809.1 - 0.19 10.2 3.6 0.2 10.2 3.6 1.0 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C TolA_bind_tri PF16331.5 ETO10809.1 - 0.2 11.8 6.5 0.24 11.5 1.9 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF2968 PF11180.8 ETO10809.1 - 0.31 10.7 7.7 0.36 10.4 7.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) TMPIT PF07851.13 ETO10809.1 - 0.31 10.3 12.4 0.33 10.1 12.4 1.0 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 ETO10809.1 - 0.31 11.1 8.1 0.38 10.8 8.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO10809.1 - 0.33 11.5 18.5 0.68 10.5 18.5 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region THOC7 PF05615.13 ETO10809.1 - 0.45 10.8 11.6 1.5 9.1 11.6 1.8 1 1 0 1 1 1 0 Tho complex subunit 7 NYD-SP28_assoc PF14775.6 ETO10809.1 - 0.7 10.0 6.9 0.74 10.0 3.1 2.4 1 1 1 2 2 2 0 Sperm tail C-terminal domain DUF4127 PF13552.6 ETO10809.1 - 0.85 8.1 5.7 0.88 8.1 5.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4127) Nup88 PF10168.9 ETO10809.1 - 0.95 7.2 14.0 1.1 7.0 14.0 1.0 1 0 0 1 1 1 0 Nuclear pore component zf-C4H2 PF10146.9 ETO10809.1 - 1.6 9.0 14.4 1.7 8.9 14.4 1.0 1 0 0 1 1 1 0 Zinc finger-containing protein Silic_transp PF03842.13 ETO10809.1 - 1.6 6.9 3.2 1.6 6.9 2.8 1.2 1 1 0 1 1 1 0 Silicon transporter GIT_CC PF16559.5 ETO10809.1 - 1.7 8.6 11.1 0.37 10.7 0.7 2.2 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor LRS4 PF10422.9 ETO10809.1 - 1.8 8.1 12.7 2.1 7.9 12.7 1.1 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 UPF0449 PF15136.6 ETO10809.1 - 4.2 7.9 11.3 11 6.5 11.3 1.8 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 FapA PF03961.13 ETO10809.1 - 5.2 5.6 14.1 5.3 5.5 14.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A bZIP_2 PF07716.15 ETO10809.1 - 7.6 6.7 14.4 0.22 11.6 3.3 2.6 1 1 1 2 2 2 0 Basic region leucine zipper YabA PF06156.13 ETO10809.1 - 8 7.2 13.1 11 6.8 5.7 2.1 1 1 1 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 ETO10809.1 - 8.7 6.2 15.4 1.2 9.0 4.4 2.7 1 1 1 2 2 2 0 Septum formation initiator UPF0242 PF06785.11 ETO10809.1 - 9.7 6.2 17.0 14 5.7 17.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus AMP-binding PF00501.28 ETO10811.1 - 3.8e-22 78.5 0.0 4.3e-22 78.3 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AI-2E_transport PF01594.16 ETO10813.1 - 0.12 11.5 3.6 0.15 11.1 3.6 1.2 1 0 0 1 1 1 0 AI-2E family transporter Nop PF01798.18 ETO10816.1 - 0.11 12.0 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin WD40 PF00400.32 ETO10818.1 - 2.7e-53 176.8 18.2 5.6e-10 39.7 0.5 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10818.1 - 3.6e-18 65.6 2.2 0.0037 17.5 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10818.1 - 5e-10 38.8 0.2 0.79 8.6 0.0 5.7 2 1 5 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO10818.1 - 1.6e-09 36.8 0.5 0.0058 15.2 0.0 3.3 2 1 0 3 3 3 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO10818.1 - 4.2e-06 26.3 1.8 0.11 11.8 0.1 3.4 1 1 4 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO10818.1 - 3e-05 22.9 5.8 0.62 8.6 0.4 4.6 2 1 3 5 5 5 3 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO10818.1 - 0.00025 21.1 0.1 0.97 9.6 0.0 4.2 3 2 1 4 4 4 1 Strictosidine synthase Coatomer_WDAD PF04053.14 ETO10818.1 - 0.00036 19.7 2.1 0.79 8.7 0.6 3.0 1 1 2 3 3 3 2 Coatomer WD associated region PD40 PF07676.12 ETO10818.1 - 0.0028 17.5 0.5 30 4.7 0.0 3.9 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Me-amine-dh_H PF06433.11 ETO10818.1 - 0.0082 15.0 0.0 0.11 11.4 0.0 2.4 2 1 1 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) Nbas_N PF15492.6 ETO10818.1 - 0.018 14.4 1.2 6.1 6.1 0.0 3.6 1 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.9 ETO10818.1 - 0.051 13.3 0.0 1.2 8.9 0.0 2.4 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain Ubiquitin_3 PF14836.6 ETO10818.1 - 0.055 13.4 0.1 1.1 9.4 0.0 2.7 3 0 0 3 3 3 0 Ubiquitin-like domain RVT_thumb PF06817.14 ETO10818.1 - 0.25 11.2 0.8 24 4.9 0.0 2.7 3 0 0 3 3 3 0 Reverse transcriptase thumb domain RCC1 PF00415.18 ETO10820.1 - 1.2e-08 35.4 1.2 2.2e-05 25.0 0.0 3.3 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO10820.1 - 1.9e-08 33.9 5.4 0.055 13.3 0.8 3.5 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat Acetyltransf_1 PF00583.25 ETO10821.1 - 3.3e-12 46.7 0.1 4.2e-12 46.3 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO10821.1 - 2.6e-11 43.6 0.0 3.2e-11 43.3 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO10821.1 - 3.3e-09 37.0 0.0 4.5e-09 36.6 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO10821.1 - 9.2e-08 32.0 0.0 1.4e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ETO10821.1 - 1.2e-05 25.3 0.0 1.9e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ETO10821.1 - 6.1e-05 23.2 0.1 7.4e-05 22.9 0.1 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Pfk_N PF18468.1 ETO10821.1 - 0.066 13.6 0.4 0.15 12.4 0.3 1.7 1 1 0 1 1 1 0 Phosphofructokinase N-terminal domain yeast DEAD PF00270.29 ETO10822.1 - 2.4e-31 108.9 0.2 1e-28 100.3 0.0 2.4 2 0 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO10822.1 - 3.7e-15 56.2 0.5 3.5e-13 49.9 0.1 2.8 2 1 0 3 3 3 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ETO10822.1 - 6.3e-06 25.7 0.3 4.4e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 ETO10822.1 - 1.5e-05 25.1 0.1 4.3e-05 23.6 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit NIF PF03031.18 ETO10822.1 - 0.02 14.7 0.7 0.031 14.0 0.7 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase FN3_7 PF18447.1 ETO10822.1 - 0.3 11.4 1.8 0.71 10.2 0.6 2.1 2 0 0 2 2 2 0 Fibronectin type III domain DNA_mis_repair PF01119.19 ETO10823.1 - 1.3e-20 73.3 2.2 4.2e-20 71.6 2.2 1.8 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain RCC1_2 PF13540.6 ETO10824.1 - 2.9e-06 26.9 0.2 0.00028 20.6 0.0 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat HEAT PF02985.22 ETO10825.1 - 1.5e-12 46.6 0.2 0.16 12.3 0.0 6.6 6 0 0 6 6 6 4 HEAT repeat NACHT PF05729.12 ETO10825.1 - 2.9e-11 43.6 0.0 1.8e-10 41.0 0.0 2.5 2 0 0 2 2 1 1 NACHT domain HEAT_2 PF13646.6 ETO10825.1 - 2.7e-08 34.1 0.0 0.0053 17.1 0.0 5.6 3 3 2 5 5 5 2 HEAT repeats Cnd1 PF12717.7 ETO10825.1 - 3.7e-06 27.1 45.8 0.00067 19.7 8.1 7.0 4 2 3 7 7 7 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO10825.1 - 1.2e-05 25.6 0.0 2.8 8.5 0.0 6.2 5 0 0 5 5 5 1 HEAT-like repeat Ank_3 PF13606.6 ETO10825.1 - 6.2e-05 23.1 0.2 0.022 15.2 0.0 4.3 3 0 0 3 3 3 1 Ankyrin repeat Vac14_Fab1_bd PF12755.7 ETO10825.1 - 0.0015 19.1 15.6 0.042 14.5 0.8 6.1 4 2 3 8 8 7 3 Vacuolar 14 Fab1-binding region Ank_5 PF13857.6 ETO10825.1 - 0.0069 16.7 0.0 0.022 15.0 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO10825.1 - 0.013 15.9 0.0 0.056 13.9 0.0 2.2 1 0 0 1 1 1 0 Ankyrin repeat AAA_22 PF13401.6 ETO10825.1 - 0.015 15.6 0.1 0.14 12.5 0.0 2.9 2 1 0 2 2 1 0 AAA domain Ank_4 PF13637.6 ETO10825.1 - 0.042 14.5 0.2 1.1 9.9 0.0 3.3 3 0 0 3 3 2 0 Ankyrin repeats (many copies) AAA_18 PF13238.6 ETO10825.1 - 0.048 14.2 1.5 0.32 11.6 0.1 3.3 3 0 0 3 3 3 0 AAA domain Mg_chelatase PF01078.21 ETO10825.1 - 0.058 12.8 0.0 0.19 11.1 0.0 1.8 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ank_2 PF12796.7 ETO10825.1 - 0.11 13.1 0.1 1.4 9.6 0.0 3.1 2 0 0 2 2 1 0 Ankyrin repeats (3 copies) AAA_16 PF13191.6 ETO10825.1 - 0.12 12.7 0.0 0.4 11.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain His_Me_b4a2 PF18275.1 ETO10825.1 - 0.17 12.0 2.1 0.98 9.5 2.1 2.4 1 0 0 1 1 1 0 His-Me finger endonuclease beta4-alpha2 domain DUF87 PF01935.17 ETO10825.1 - 0.35 10.9 5.2 3.3 7.7 0.0 4.2 3 1 1 4 4 4 0 Helicase HerA, central domain ANAPC3 PF12895.7 ETO10825.1 - 0.46 10.7 4.4 1.5 9.1 0.2 3.9 3 0 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.32 ETO10826.1 - 2e-32 110.7 29.3 7.6e-06 26.6 1.1 7.1 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10826.1 - 6.1e-08 32.9 2.4 0.31 11.4 0.0 5.2 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10826.1 - 9.9e-07 27.8 3.5 2 7.0 0.0 4.8 2 2 2 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO10826.1 - 0.017 15.1 1.7 0.18 11.9 0.2 2.9 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO10827.1 - 1.1e-147 475.5 53.4 1.5e-10 41.4 0.1 15.7 14 1 1 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10827.1 - 2.3e-68 226.5 7.3 1.6e-06 28.3 0.0 13.6 2 2 11 13 13 13 12 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO10827.1 - 7.2e-34 117.5 2.5 2e-05 24.1 0.1 9.9 7 2 2 9 9 9 7 WD40-like domain PQQ_2 PF13360.6 ETO10827.1 - 1.1e-08 34.9 6.3 0.82 9.2 3.0 5.9 2 1 2 4 4 4 3 PQQ-like domain PD40 PF07676.12 ETO10827.1 - 2.7e-08 33.5 10.3 20 5.3 0.0 11.3 13 0 0 13 13 13 0 WD40-like Beta Propeller Repeat Germane PF10646.9 ETO10827.1 - 2.9e-06 28.0 0.3 2.2 9.1 0.0 7.8 4 3 4 8 8 8 1 Sporulation and spore germination NACHT PF05729.12 ETO10827.1 - 6e-06 26.3 0.0 1.5e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 ETO10827.1 - 9.7e-06 24.3 7.6 0.015 13.8 0.2 5.2 5 1 0 6 6 6 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO10827.1 - 1.6e-05 24.6 0.0 2.1 8.5 0.0 6.7 8 0 0 8 8 8 1 PQQ enzyme repeat AAA_22 PF13401.6 ETO10827.1 - 0.0014 18.9 0.0 0.0052 17.1 0.0 2.0 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO10827.1 - 0.013 16.1 0.1 0.12 12.9 0.0 2.9 2 0 0 2 2 2 0 AAA domain EcpB_C PF18649.1 ETO10827.1 - 0.015 15.2 0.0 0.061 13.3 0.0 2.0 1 0 0 1 1 1 0 EcpB C-terminal domain Pentapeptide PF00805.22 ETO10827.1 - 0.018 14.7 0.1 3.5 7.4 0.0 2.7 2 0 0 2 2 2 0 Pentapeptide repeats (8 copies) Cas_CT1975 PF09344.10 ETO10827.1 - 0.062 12.8 1.4 0.21 11.0 0.0 2.2 2 0 0 2 2 2 0 CT1975-like protein DUF5570 PF17731.1 ETO10827.1 - 0.15 12.2 21.9 23 5.1 0.0 8.6 6 2 2 9 9 9 0 Family of unknown function (DUF5570) Kelch_6 PF13964.6 ETO10828.1 - 0.019 15.2 0.2 0.15 12.4 0.0 2.3 3 0 0 3 3 3 0 Kelch motif DUF368 PF04018.13 ETO10830.1 - 0.072 12.7 3.0 0.92 9.0 0.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF368) CAP_GLY PF01302.25 ETO10831.1 - 0.00032 20.7 0.0 0.0007 19.6 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain DUF5436 PF17504.2 ETO10831.1 - 0.083 13.2 1.1 0.15 12.4 1.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5436) APOBEC4 PF18775.1 ETO10831.1 - 0.48 10.6 5.4 0.75 10.0 3.2 2.2 2 1 0 2 2 2 0 APOBEC4 WD40 PF00400.32 ETO10832.1 - 3e-19 69.0 6.3 6.6e-07 29.9 0.2 4.1 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO10832.1 - 0.0046 15.7 0.1 0.35 9.4 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 PRKCSH_1 PF13015.6 ETO10834.1 - 4e-10 39.6 3.4 6.4e-10 38.9 2.8 1.7 1 1 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 ETO10834.1 - 0.0076 17.2 6.4 0.0076 17.2 6.4 3.2 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein Macoilin PF09726.9 ETO10834.1 - 4.1 5.8 26.4 1.9 6.9 15.0 2.1 2 0 0 2 2 2 0 Macoilin family Ribosomal_L29 PF00831.23 ETO10835.1 - 1.5e-17 63.3 6.0 1.5e-17 63.3 6.0 2.5 3 0 0 3 3 3 1 Ribosomal L29 protein LVIVD PF08309.11 ETO10836.1 - 0.092 12.1 0.4 0.55 9.6 0.6 2.1 2 0 0 2 2 2 0 LVIVD repeat RGS PF00615.19 ETO10837.1 - 0.0029 17.8 1.1 0.0065 16.7 0.6 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF1240 PF06836.12 ETO10838.1 - 0.17 12.5 0.2 0.17 12.5 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1240) Phosphoesterase PF04185.14 ETO10839.1 - 1.7e-36 126.2 0.6 4.8e-36 124.7 0.6 1.6 1 1 0 1 1 1 1 Phosphoesterase family Sulfatase PF00884.23 ETO10839.1 - 0.071 12.5 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Sulfatase WD40 PF00400.32 ETO10840.1 - 1.6e-37 126.8 4.9 1.1e-10 41.9 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10840.1 - 1.6e-14 53.9 1.1 8.9e-06 25.9 0.0 4.3 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO10840.1 - 1.1e-08 35.3 1.3 2.3e-05 24.3 0.8 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO10840.1 - 1.6e-08 33.9 0.2 0.0046 16.0 0.0 4.4 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO10840.1 - 1.2e-05 25.1 0.3 1.5 8.8 0.0 3.8 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO10840.1 - 0.00017 21.0 18.8 0.061 12.7 15.3 3.4 2 1 0 2 2 2 2 WD40-like domain Proteasome_A_N PF10584.9 ETO10840.1 - 1.5 8.6 4.4 34 4.3 0.1 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Rpp20 PF12328.8 ETO10841.1 - 0.0027 17.7 1.4 0.0039 17.1 1.4 1.2 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Rota_NSP4 PF01452.16 ETO10841.1 - 0.027 14.2 1.7 0.03 14.0 1.7 1.1 1 0 0 1 1 1 0 Rotavirus non structural protein Ureide_permease PF07168.11 ETO10841.1 - 0.12 11.1 1.3 0.16 10.7 1.3 1.1 1 0 0 1 1 1 0 Ureide permease DUF4162 PF13732.6 ETO10842.1 - 0.0017 19.0 1.7 0.0046 17.6 1.7 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4162) ABC_tran PF00005.27 ETO10843.1 - 2.4e-17 63.8 0.1 8.8e-17 61.9 0.0 1.8 2 1 1 3 3 3 1 ABC transporter AAA_27 PF13514.6 ETO10843.1 - 0.012 15.3 0.0 2 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 ETO10844.1 - 8.5e-27 94.2 24.2 8.5e-27 94.2 24.2 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein DUF3687 PF12459.8 ETO10844.1 - 7.3 6.2 9.4 0.25 10.9 0.3 3.2 2 0 0 2 2 2 0 D-Ala-teichoic acid biosynthesis protein APP_E2 PF12925.7 ETO10845.1 - 0.017 14.8 9.2 0.045 13.4 9.2 1.6 1 0 0 1 1 1 0 E2 domain of amyloid precursor protein Mvb12 PF09452.10 ETO10845.1 - 0.11 12.9 4.2 0.32 11.5 4.2 1.7 1 0 0 1 1 1 0 ESCRT-I subunit Mvb12 Nup160 PF11715.8 ETO10846.1 - 0.0012 17.6 0.6 0.0034 16.1 0.1 1.8 1 1 1 2 2 2 1 Nucleoporin Nup120/160 WD40 PF00400.32 ETO10846.1 - 0.049 14.5 0.2 0.11 13.5 0.2 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat AAA_12 PF13087.6 ETO10846.1 - 0.077 12.6 2.3 0.1 12.2 2.3 1.2 1 0 0 1 1 1 0 AAA domain DUF4302 PF14135.6 ETO10849.1 - 0.013 15.5 1.7 0.018 15.0 1.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4302) Ank_4 PF13637.6 ETO10850.1 - 1.3e-07 32.1 0.0 5e-05 23.8 0.0 2.4 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO10850.1 - 1.5e-07 31.9 0.0 2.9e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO10850.1 - 7.1e-07 29.1 0.0 0.0077 16.7 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETO10850.1 - 0.00088 19.6 0.1 0.0046 17.4 0.0 2.1 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO10850.1 - 0.02 15.2 0.0 1.4 9.4 0.0 2.6 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Folate_carrier PF01770.18 ETO10852.1 - 0.0036 16.1 3.0 0.0041 15.9 3.0 1.0 1 0 0 1 1 1 1 Reduced folate carrier Folate_carrier PF01770.18 ETO10853.1 - 0.00015 20.6 1.4 0.00016 20.6 1.4 1.0 1 0 0 1 1 1 1 Reduced folate carrier Connexin PF00029.19 ETO10853.1 - 0.11 12.2 2.5 0.13 12.0 2.5 1.0 1 0 0 1 1 1 0 Connexin STN1_2 PF09170.10 ETO10855.1 - 0.014 15.6 2.7 0.018 15.2 2.0 1.5 1 1 0 1 1 1 0 CST, Suppressor of cdc thirteen homolog, complex subunit STN1 Xpo1 PF08389.12 ETO10856.1 - 0.0019 18.2 1.8 0.0042 17.2 1.8 1.6 1 1 0 1 1 1 1 Exportin 1-like protein HU-CCDC81_euk_2 PF18289.1 ETO10856.1 - 0.0046 17.1 0.2 1 9.5 0.1 2.4 2 0 0 2 2 2 2 CCDC81 eukaryotic HU domain 2 FANCI_HD2 PF14680.6 ETO10856.1 - 0.037 13.3 1.9 0.054 12.7 1.6 1.3 1 1 0 1 1 1 0 FANCI helical domain 2 Picorna_P3A PF06363.11 ETO10856.1 - 0.049 13.5 1.4 1 9.3 0.6 2.6 1 1 2 3 3 3 0 Picornaviridae P3A protein Prion PF00377.18 ETO10856.1 - 0.1 12.4 0.6 0.31 10.9 0.2 1.9 1 1 1 2 2 2 0 Prion/Doppel alpha-helical domain MitMem_reg PF13012.6 ETO10857.1 - 2.8e-13 50.2 0.3 4.9e-13 49.5 0.3 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ETO10857.1 - 4.6e-12 46.0 0.0 1.1e-11 44.8 0.0 1.6 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RVT_1 PF00078.27 ETO10858.1 - 5.1e-22 78.5 0.0 6.3e-22 78.2 0.0 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) tRNA-synt_1c_C PF03950.18 ETO10859.1 - 0.00017 21.6 5.7 0.00021 21.2 5.7 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain DUF2149 PF09919.9 ETO10859.1 - 3.5 7.9 6.5 1.5 9.1 2.2 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) TRAP-gamma PF07074.12 ETO10859.1 - 5 6.7 13.6 0.39 10.3 8.5 1.7 2 0 0 2 2 2 0 Translocon-associated protein, gamma subunit (TRAP-gamma) PAP_RNA-bind PF04926.15 ETO10860.1 - 0.007 16.0 0.1 0.007 16.0 0.1 2.9 2 1 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain PA26 PF04636.13 ETO10860.1 - 2.4 7.0 10.5 0.18 10.7 4.7 1.9 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) Mob1_phocein PF03637.17 ETO10861.1 - 0.019 15.0 0.3 0.023 14.7 0.3 1.3 1 1 0 1 1 1 0 Mob1/phocein family Nup35_RRM PF05172.13 ETO10861.1 - 0.093 12.7 0.2 0.17 11.9 0.1 1.4 1 1 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF3399 PF11879.8 ETO10862.1 - 0.053 13.9 0.0 1.1 9.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) FliJ PF02050.16 ETO10863.1 - 0.0018 18.5 12.9 0.0038 17.4 12.9 1.5 1 0 0 1 1 1 1 Flagellar FliJ protein DUF722 PF05263.11 ETO10863.1 - 0.0037 17.5 1.4 0.0076 16.5 1.4 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF722) Fib_alpha PF08702.10 ETO10863.1 - 0.0051 17.0 11.0 0.0051 17.0 11.0 2.5 3 0 0 3 3 2 1 Fibrinogen alpha/beta chain family Trimer_CC PF08954.11 ETO10863.1 - 0.014 14.9 0.2 0.014 14.9 0.2 2.5 2 0 0 2 2 1 0 Trimerisation motif Spc7 PF08317.11 ETO10863.1 - 0.015 14.2 9.4 0.031 13.2 9.4 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4298 PF14131.6 ETO10863.1 - 0.027 14.4 0.9 0.027 14.4 0.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4298) CHD5 PF04420.14 ETO10863.1 - 0.066 13.1 4.5 0.15 11.9 4.5 1.6 1 0 0 1 1 1 0 CHD5-like protein DUF4407 PF14362.6 ETO10863.1 - 0.066 12.5 7.1 0.1 11.9 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF641 PF04859.12 ETO10863.1 - 0.089 13.1 7.9 0.25 11.7 7.9 1.7 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) BLOC1_2 PF10046.9 ETO10863.1 - 0.22 11.9 10.0 0.62 10.4 10.0 1.8 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF848 PF05852.11 ETO10863.1 - 0.24 11.5 6.1 0.58 10.3 6.1 1.6 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) YvrJ PF12841.7 ETO10863.1 - 0.25 10.9 0.9 0.54 9.8 0.9 1.6 1 0 0 1 1 1 0 YvrJ protein family DUF1266 PF06889.11 ETO10863.1 - 0.28 11.2 3.8 1 9.4 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1266) TMF_DNA_bd PF12329.8 ETO10863.1 - 0.28 11.2 12.5 0.032 14.2 7.2 2.2 2 0 0 2 2 1 0 TATA element modulatory factor 1 DNA binding DUF5082 PF16888.5 ETO10863.1 - 0.31 11.3 16.7 0.32 11.3 7.2 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) FemAB PF02388.16 ETO10863.1 - 0.33 9.8 8.3 0.59 8.9 8.3 1.3 1 0 0 1 1 1 0 FemAB family ABC_tran_CTD PF16326.5 ETO10863.1 - 0.5 10.7 9.0 0.43 10.8 3.0 2.7 1 1 1 2 2 2 0 ABC transporter C-terminal domain HemX PF04375.14 ETO10863.1 - 0.5 9.6 14.9 0.79 8.9 14.9 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase XhlA PF10779.9 ETO10863.1 - 0.73 10.1 3.7 2.4 8.4 3.7 1.9 1 0 0 1 1 1 0 Haemolysin XhlA ACCA PF03255.14 ETO10863.1 - 0.8 9.6 9.7 1.8 8.4 0.0 3.1 2 1 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CorA PF01544.18 ETO10863.1 - 1 8.6 5.5 1.9 7.7 5.5 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Raptor_N PF14538.6 ETO10863.1 - 1.1 9.2 8.8 0.35 10.8 2.7 2.2 2 0 0 2 2 2 0 Raptor N-terminal CASPase like domain Laminin_II PF06009.12 ETO10863.1 - 1.3 9.0 11.0 3.8 7.5 11.0 1.7 1 0 0 1 1 1 0 Laminin Domain II HrpB7 PF09486.10 ETO10863.1 - 2.4 8.5 7.6 19 5.6 7.6 2.1 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF4175 PF13779.6 ETO10863.1 - 2.9 5.7 10.0 4.1 5.2 10.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) SlyX PF04102.12 ETO10863.1 - 3.3 8.4 16.8 0.061 14.0 5.3 2.7 1 1 1 2 2 2 0 SlyX Uds1 PF15456.6 ETO10863.1 - 3.3 7.9 11.0 0.55 10.4 6.2 2.2 2 0 0 2 2 2 0 Up-regulated During Septation Cnn_1N PF07989.11 ETO10863.1 - 3.4 7.9 12.3 0.74 10.0 5.8 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 ETO10863.1 - 3.7 7.6 8.3 8.4 6.5 7.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 ETO10863.1 - 3.7 8.1 17.0 0.16 12.5 8.0 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 RNase_H2-Ydr279 PF09468.10 ETO10863.1 - 4.9 7.3 13.7 9.3 6.4 11.9 2.5 1 1 1 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain LPP PF04728.13 ETO10863.1 - 5.2 7.5 8.7 0.42 11.0 0.9 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DUF2019 PF09450.10 ETO10864.1 - 0.5 10.3 4.2 13 5.8 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF2019) Epimerase PF01370.21 ETO10866.1 - 4.6e-05 23.0 0.0 5.7e-05 22.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family RNAse_A_bac PF18431.1 ETO10866.1 - 0.12 13.4 0.1 0.17 12.9 0.1 1.3 1 0 0 1 1 1 0 Bacterial CdiA-CT RNAse A domain adh_short PF00106.25 ETO10866.1 - 0.15 11.5 0.0 0.26 10.7 0.0 1.4 1 1 0 1 1 1 0 short chain dehydrogenase Ribosomal_L4 PF00573.22 ETO10867.1 - 5.3e-19 68.7 0.1 2e-18 66.8 0.1 1.8 1 1 0 1 1 1 1 Ribosomal protein L4/L1 family Cation_efflux PF01545.21 ETO10868.1 - 3.7e-21 75.8 3.8 4.7e-21 75.4 3.8 1.1 1 0 0 1 1 1 1 Cation efflux family DUF2162 PF09930.9 ETO10868.1 - 0.051 13.0 1.9 0.1 12.0 1.9 1.4 1 0 0 1 1 1 0 Predicted transporter (DUF2162) Glyco_hydro_12 PF01670.16 ETO10869.1 - 8.1e-11 42.3 1.8 1.9e-10 41.1 1.4 1.6 1 1 1 2 2 2 1 Glycosyl hydrolase family 12 CHAT PF12770.7 ETO10870.1 - 2.2e-05 24.0 0.0 2.3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 CHAT domain Terminase_4 PF05119.12 ETO10870.1 - 0.096 13.1 0.1 1 9.8 0.1 2.3 1 1 0 1 1 1 0 Phage terminase, small subunit UPF0180 PF03698.13 ETO10873.1 - 0.046 13.9 0.0 0.09 13.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) ketoacyl-synt PF00109.26 ETO10873.1 - 0.079 12.5 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain DUF4758 PF15950.5 ETO10873.1 - 0.21 11.9 2.7 4 7.8 0.5 2.5 2 1 0 2 2 2 0 Putative sperm flagellar membrane protein Histone_HNS PF00816.21 ETO10873.1 - 1.2 10.0 5.1 0.59 11.0 0.2 2.3 1 1 1 2 2 2 0 H-NS histone family TMEM132D_C PF15706.5 ETO10874.1 - 0.069 12.9 4.3 2.7 7.9 0.1 2.5 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Pkinase_Tyr PF07714.17 ETO10875.1 - 1.2e-65 221.4 0.0 1.6e-65 221.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO10875.1 - 9.4e-52 176.0 0.0 1.3e-51 175.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO10875.1 - 6.3e-07 28.5 0.0 1.2e-06 27.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO10875.1 - 0.00022 20.6 0.1 0.00046 19.6 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family HupF_HypC PF01455.18 ETO10875.1 - 0.11 12.7 0.0 0.3 11.3 0.0 1.7 1 0 0 1 1 1 0 HupF/HypC family AID PF18767.1 ETO10876.1 - 0.079 13.0 0.0 0.24 11.4 0.0 1.8 1 0 0 1 1 1 0 Activation induced deaminase DUF1336 PF07059.12 ETO10877.1 - 5.1e-34 118.3 0.1 8.7e-32 111.0 0.0 3.2 2 1 0 2 2 2 1 Protein of unknown function (DUF1336) FYVE PF01363.21 ETO10877.1 - 6.9e-06 26.1 14.5 2.2e-05 24.5 14.5 2.0 1 0 0 1 1 1 1 FYVE zinc finger LMBR1 PF04791.16 ETO10877.1 - 0.0028 16.7 4.5 0.0028 16.7 4.5 2.3 2 0 0 2 2 2 1 LMBR1-like membrane protein Mem_trans PF03547.18 ETO10877.1 - 0.0045 15.4 5.3 0.053 11.9 0.1 2.2 2 0 0 2 2 2 2 Membrane transport protein Dapper PF15268.6 ETO10877.1 - 0.021 13.7 42.2 0.18 10.7 19.6 2.2 2 0 0 2 2 2 0 Dapper PDZ_6 PF17820.1 ETO10877.1 - 0.072 12.9 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 PDZ domain SOG2 PF10428.9 ETO10877.1 - 5.9 6.0 28.2 6.3 5.9 0.1 2.4 2 0 0 2 2 2 0 RAM signalling pathway protein Taxilin PF09728.9 ETO10878.1 - 1.8e-05 24.1 38.5 0.0022 17.2 31.1 2.8 1 1 1 2 2 2 2 Myosin-like coiled-coil protein Actin PF00022.19 ETO10880.1 - 6.1e-91 305.0 0.0 4.4e-90 302.2 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO10880.1 - 0.0012 17.8 0.2 0.0017 17.2 0.2 1.1 1 0 0 1 1 1 1 MreB/Mbl protein DUF3682 PF12446.8 ETO10881.1 - 6.5 7.2 11.2 11 6.5 11.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) WD40 PF00400.32 ETO10883.1 - 6.7e-52 172.3 14.4 1.1e-09 38.7 0.3 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10883.1 - 1.8e-21 76.2 0.4 0.0058 16.9 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10883.1 - 2.4e-12 46.5 0.2 0.0078 15.2 0.0 4.9 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO10883.1 - 3e-10 40.3 0.1 4.6e-05 23.4 0.1 2.5 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO10883.1 - 1.3e-09 37.9 0.3 0.0032 16.8 0.2 3.1 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO10883.1 - 1.7e-08 33.6 0.6 0.17 10.5 0.1 4.6 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO10883.1 - 7.8e-07 28.7 0.8 0.0091 15.4 0.1 3.7 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO10883.1 - 8.7e-07 28.7 2.8 0.91 9.5 0.0 4.9 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO10883.1 - 5e-06 25.3 0.2 0.0031 16.1 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO10883.1 - 9.1e-05 22.0 7.8 3.6 7.3 0.1 4.5 4 0 0 4 4 4 2 Proteasome subunit A N-terminal signature Coatomer_WDAD PF04053.14 ETO10883.1 - 9.3e-05 21.7 0.5 0.0019 17.3 0.3 2.2 1 1 1 2 2 2 1 Coatomer WD associated region PQQ PF01011.21 ETO10883.1 - 0.0071 16.2 0.0 10 6.2 0.0 3.7 3 0 0 3 3 3 0 PQQ enzyme repeat lci PF12197.8 ETO10883.1 - 0.013 15.3 1.2 4.1 7.3 0.0 2.9 3 0 0 3 3 3 0 Bacillus cereus group antimicrobial protein Nucleoporin_N PF08801.11 ETO10883.1 - 0.013 14.2 1.9 11 4.6 0.0 4.0 1 1 1 2 2 2 0 Nup133 N terminal like PALB2_WD40 PF16756.5 ETO10883.1 - 0.015 14.2 1.4 3.9 6.3 0.0 3.5 2 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF5474 PF17568.2 ETO10883.1 - 0.016 15.3 0.1 24 5.1 0.0 3.3 3 1 0 3 3 3 0 Family of unknown function (DUF5474) PQQ_2 PF13360.6 ETO10883.1 - 0.019 14.5 0.1 0.39 10.2 0.1 2.6 1 1 0 1 1 1 0 PQQ-like domain DPPIV_N PF00930.21 ETO10883.1 - 0.019 13.7 0.0 6.8 5.3 0.0 3.6 3 2 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ricin_B_lectin PF00652.22 ETO10883.1 - 0.03 14.6 1.1 1.2 9.4 0.7 3.1 1 1 4 5 5 5 0 Ricin-type beta-trefoil lectin domain VID27 PF08553.10 ETO10883.1 - 0.03 13.4 0.0 0.25 10.3 0.0 2.1 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain Resistin PF06954.11 ETO10883.1 - 0.085 13.4 0.4 69 4.1 0.0 3.5 2 1 2 4 4 4 0 Resistin USP7_C2 PF14533.6 ETO10883.1 - 0.11 12.2 0.1 2.2 7.9 0.1 2.4 2 1 1 3 3 3 0 Ubiquitin-specific protease C-terminal Kelch_2 PF07646.15 ETO10884.1 - 7.5e-05 22.6 1.3 0.1 12.6 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO10884.1 - 0.28 10.8 4.0 4.8 6.8 0.1 3.2 4 0 0 4 4 4 0 Kelch motif PCI PF01399.27 ETO10885.1 - 1e-05 26.0 0.7 1e-05 26.0 0.7 2.9 3 1 0 3 3 3 1 PCI domain P5-ATPase PF12409.8 ETO10885.1 - 1.8 8.7 5.4 0.66 10.1 0.3 2.4 2 0 0 2 2 2 0 P5-type ATPase cation transporter Btz PF09405.10 ETO10885.1 - 2.5 8.4 6.6 4.5 7.6 6.6 1.3 1 0 0 1 1 1 0 CASC3/Barentsz eIF4AIII binding zf-TRAF PF02176.18 ETO10886.1 - 0.0031 18.2 6.9 0.0031 18.2 6.9 2.7 4 0 0 4 4 4 1 TRAF-type zinc finger DUF2675 PF11247.8 ETO10886.1 - 0.045 13.9 0.2 3.9 7.7 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2675) MamL-1 PF09596.10 ETO10886.1 - 0.15 12.4 2.1 0.18 12.1 0.1 2.1 2 0 0 2 2 2 0 MamL-1 domain Orf78 PF06024.12 ETO10887.1 - 0.0087 16.3 0.5 0.0087 16.3 0.5 4.6 3 2 1 4 4 4 2 Orf78 (ac78) TMEM51 PF15345.6 ETO10887.1 - 0.016 15.1 0.0 0.036 13.9 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4834 PF16118.5 ETO10887.1 - 2.2 9.3 12.3 0.29 12.1 1.1 4.0 4 1 1 5 5 5 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO10888.1 - 7e-11 42.5 5.7 4.3e-08 33.7 0.8 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO10888.1 - 4.1e-06 27.4 1.9 4.1e-06 27.4 1.9 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO10888.1 - 0.013 15.8 0.3 0.12 12.7 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Exonuc_VII_L PF02601.15 ETO10888.1 - 0.22 11.1 5.0 0.27 10.8 5.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit V-ATPase_G PF03179.15 ETO10888.1 - 0.52 10.9 13.4 0.34 11.4 10.7 2.1 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit Pyr_redox PF00070.27 ETO10889.1 - 8.2 7.1 6.6 1.3 9.6 0.3 2.7 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Thioredoxin_10 PF17991.1 ETO10892.1 - 0.021 15.3 0.1 0.025 15.2 0.1 1.1 1 0 0 1 1 1 0 Thioredoxin like C-terminal domain S-methyl_trans PF02574.16 ETO10892.1 - 0.044 13.6 0.0 0.05 13.4 0.0 1.1 1 0 0 1 1 1 0 Homocysteine S-methyltransferase DUF3086 PF11285.8 ETO10892.1 - 0.071 12.2 0.4 0.084 12.0 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) DUF3713 PF12506.8 ETO10892.1 - 0.073 13.4 1.0 3.7 7.9 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3713) Dicty_REP PF05086.12 ETO10896.1 - 0.0078 14.3 15.5 0.01 13.9 15.5 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO10896.1 - 0.017 15.1 1.3 0.037 14.0 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) G-alpha PF00503.20 ETO10896.1 - 0.23 10.6 12.0 0.47 9.6 12.0 1.5 1 1 0 1 1 1 0 G-protein alpha subunit Mucin PF01456.17 ETO10896.1 - 0.77 9.7 13.4 0.32 11.0 10.7 1.7 1 1 1 2 2 2 0 Mucin-like glycoprotein XRN_M PF17846.1 ETO10896.1 - 6.6 5.6 9.2 9.2 5.1 9.2 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Helicase_Sgs1 PF11408.8 ETO10899.1 - 0.054 13.6 0.1 0.11 12.6 0.0 1.6 1 1 0 1 1 1 0 Sgs1 RecQ helicase LYRIC PF15686.5 ETO10901.1 - 0.029 13.9 6.7 0.037 13.6 6.7 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family U-box PF04564.15 ETO10902.1 - 1.4e-06 28.3 2.5 5.3e-06 26.5 0.3 2.9 2 1 0 2 2 2 1 U-box domain Cbl_N2 PF02761.14 ETO10902.1 - 0.18 12.5 0.4 0.18 12.5 0.4 2.6 1 1 1 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain E2F_CC-MB PF16421.5 ETO10902.1 - 4.1 7.8 12.8 1.3 9.4 5.3 2.5 1 1 1 2 2 2 0 E2F transcription factor CC-MB domain LMBR1 PF04791.16 ETO10902.1 - 5.6 5.8 13.4 6.6 5.5 13.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF812 PF05667.11 ETO10906.1 - 0.0006 18.8 1.4 0.0006 18.8 1.4 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF812) DUF2344 PF10105.9 ETO10906.1 - 0.028 14.3 0.8 0.028 14.3 0.8 1.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2344) WD40 PF00400.32 ETO10907.1 - 3.1e-44 148.1 23.4 7.7e-08 32.9 0.7 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10907.1 - 1.1e-13 51.2 1.6 0.0068 16.7 0.0 5.7 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10907.1 - 6.3e-11 41.6 4.0 0.0016 17.2 0.1 4.7 2 2 0 4 4 4 2 Nucleoporin Nup120/160 DUF4460 PF14687.6 ETO10908.1 - 0.053 13.6 0.8 0.53 10.4 0.8 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4460) RasGEF PF00617.19 ETO10909.1 - 1.6e-21 77.3 0.2 4.3e-21 75.9 0.1 1.7 1 1 1 2 2 2 1 RasGEF domain YppF PF14178.6 ETO10909.1 - 0.011 15.5 0.1 0.05 13.5 0.1 2.1 1 0 0 1 1 1 0 YppF-like protein adh_short PF00106.25 ETO10910.1 - 2e-16 60.0 0.0 2.9e-16 59.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO10910.1 - 6.6e-11 42.2 0.0 8.4e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 ETO10910.1 - 0.0046 16.4 0.1 0.024 14.0 0.0 1.9 2 0 0 2 2 2 1 Fungal family of unknown function (DUF1776) KR PF08659.10 ETO10910.1 - 0.019 14.9 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 KR domain Aminotran_1_2 PF00155.21 ETO10911.1 - 1.4e-17 63.9 0.0 3.6e-17 62.6 0.0 1.6 1 1 0 1 1 1 1 Aminotransferase class I and II Aminotran_MocR PF12897.7 ETO10911.1 - 0.07 11.9 0.0 0.13 11.0 0.0 1.4 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase RNaseH_C PF09293.10 ETO10911.1 - 0.073 13.4 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 T4 RNase H, C terminal Mpp10 PF04006.12 ETO10912.1 - 0.0042 15.6 21.4 0.0048 15.4 21.4 1.1 1 0 0 1 1 1 1 Mpp10 protein SDA1 PF05285.12 ETO10912.1 - 0.023 14.2 28.2 0.029 13.8 28.2 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO10912.1 - 0.025 12.8 25.0 0.028 12.7 25.0 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO10912.1 - 0.065 12.6 32.3 0.083 12.2 32.3 1.2 1 0 0 1 1 1 0 BUD22 POP1 PF06978.11 ETO10912.1 - 0.47 10.4 8.2 0.67 9.9 8.2 1.1 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 SR-25 PF10500.9 ETO10912.1 - 0.93 9.0 40.8 1.4 8.5 40.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 ETO10912.1 - 0.97 7.6 27.1 1.3 7.2 27.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Smg8_Smg9 PF10220.9 ETO10912.1 - 2.8 6.1 15.6 3.7 5.8 15.6 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Raftlin PF15250.6 ETO10912.1 - 3 6.5 15.6 4.1 6.1 15.6 1.2 1 0 0 1 1 1 0 Raftlin Apt1 PF10351.9 ETO10912.1 - 4.9 5.9 25.9 6.5 5.5 25.9 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SLC12 PF03522.15 ETO10912.1 - 9.9 5.1 15.7 17 4.3 15.7 1.4 1 0 0 1 1 1 0 Solute carrier family 12 TPR_19 PF14559.6 ETO10913.1 - 0.0015 19.0 0.1 0.15 12.6 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO10913.1 - 0.0065 16.1 0.1 0.016 14.8 0.1 1.8 2 0 0 2 2 2 1 TPR repeat TPR_16 PF13432.6 ETO10913.1 - 0.029 15.0 0.0 0.31 11.7 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO10913.1 - 0.034 14.5 0.1 7.6 7.2 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF2457 PF10446.9 ETO10914.1 - 0.59 9.2 7.8 0.9 8.6 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Orf78 PF06024.12 ETO10914.1 - 6.4 7.1 7.4 18 5.7 7.4 1.8 1 0 0 1 1 1 0 Orf78 (ac78) CAP_GLY PF01302.25 ETO10916.1 - 1.5e-21 76.2 0.5 1.9e-15 56.6 0.1 3.2 3 0 0 3 3 3 3 CAP-Gly domain Ank_2 PF12796.7 ETO10917.1 - 0.00019 21.9 0.0 0.63 10.7 0.0 2.5 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO10917.1 - 0.029 14.7 0.2 1.2 9.5 0.0 3.1 4 0 0 4 4 4 0 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO10917.1 - 0.07 13.7 0.3 14 6.4 0.0 3.5 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Ank PF00023.30 ETO10917.1 - 0.12 12.8 0.0 11 6.6 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeat AAA PF00004.29 ETO10918.1 - 0.00017 22.0 0.0 0.0018 18.7 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO10918.1 - 0.0012 18.4 1.0 0.0032 17.0 0.1 2.2 3 0 0 3 3 3 1 P-loop containing dynein motor region AAA_5 PF07728.14 ETO10918.1 - 0.008 16.2 0.0 0.038 14.0 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO10918.1 - 0.085 13.1 0.1 2.9 8.1 0.0 2.7 2 1 1 3 3 3 0 AAA domain PQQ PF01011.21 ETO10919.1 - 1.4e-12 46.9 2.7 5.4e-07 29.2 0.0 5.1 5 0 0 5 5 5 2 PQQ enzyme repeat PQQ_3 PF13570.6 ETO10919.1 - 1.7e-06 28.3 0.2 0.11 13.1 0.0 3.7 4 0 0 4 4 4 2 PQQ-like domain PQQ_2 PF13360.6 ETO10919.1 - 0.0013 18.4 0.0 0.0078 15.8 0.0 2.2 1 1 1 2 2 2 1 PQQ-like domain TFIIA PF03153.13 ETO10920.1 - 0.0023 18.0 43.2 0.0036 17.4 43.2 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 ETO10920.1 - 7.3 4.7 29.3 9.8 4.3 29.3 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ArAE_1_C PF11728.8 ETO10921.1 - 0.062 13.3 2.1 6.5 6.7 1.2 2.5 2 0 0 2 2 2 0 Putative aromatic acid exporter C-terminal domain Lectin_N PF03954.14 ETO10921.1 - 0.086 12.6 0.2 0.22 11.3 0.2 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Plug_translocon PF10559.9 ETO10921.1 - 0.24 11.3 0.3 2.5 8.0 0.2 2.3 2 0 0 2 2 2 0 Plug domain of Sec61p Mito_fiss_reg PF05308.11 ETO10921.1 - 3.1 7.8 17.9 0.5 10.4 6.2 2.6 2 0 0 2 2 2 0 Mitochondrial fission regulator PRIMA1 PF16101.5 ETO10921.1 - 9.1 6.3 14.2 22 5.1 14.2 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_GLY PF01302.25 ETO10922.1 - 5.9e-15 55.0 0.1 1.2e-14 54.1 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain PUB PF09409.10 ETO10923.1 - 0.0011 18.9 1.4 0.0033 17.3 0.5 2.3 3 0 0 3 3 3 1 PUB domain 7tm_7 PF08395.12 ETO10924.1 - 0.00044 19.6 3.8 0.0006 19.1 3.8 1.1 1 0 0 1 1 1 1 7tm Chemosensory receptor Pex24p PF06398.11 ETO10924.1 - 0.0056 15.7 0.3 0.0056 15.7 0.3 2.3 2 1 0 2 2 2 1 Integral peroxisomal membrane peroxin TRP PF06011.12 ETO10924.1 - 0.021 13.6 0.2 0.027 13.2 0.2 1.3 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel HemY_N PF07219.13 ETO10924.1 - 0.27 11.4 0.0 0.27 11.4 0.0 2.2 3 0 0 3 3 3 0 HemY protein N-terminus DcrB PF08786.11 ETO10924.1 - 0.4 10.8 6.7 1 9.5 6.7 1.7 1 0 0 1 1 1 0 DcrB UPF0182 PF03699.13 ETO10924.1 - 0.49 8.5 4.0 0.71 7.9 4.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) Rtf2 PF04641.12 ETO10924.1 - 5.8 6.2 33.4 9.6 5.5 28.5 2.8 1 1 2 3 3 3 0 Rtf2 RING-finger RtcB PF01139.17 ETO10925.1 - 7.6e-149 496.4 0.7 4.3e-92 309.4 0.8 2.1 1 1 0 2 2 2 2 tRNA-splicing ligase RtcB DUF4370 PF14290.6 ETO10925.1 - 0.048 13.5 0.6 1.6 8.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4370) DUF5526 PF17664.1 ETO10927.1 - 0.021 14.4 1.4 0.032 13.8 1.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5526) RNA_pol_A_bac PF01000.26 ETO10928.1 - 5.7e-11 42.8 0.0 3.1e-10 40.4 0.0 2.2 2 1 0 2 2 2 1 RNA polymerase Rpb3/RpoA insert domain Actin_micro PF17003.5 ETO10928.1 - 0.006 15.8 2.1 0.0086 15.3 2.1 1.1 1 0 0 1 1 1 1 Putative actin-like family Fer4_7 PF12838.7 ETO10928.1 - 0.026 15.1 0.8 0.061 13.9 0.8 1.6 1 0 0 1 1 1 0 4Fe-4S dicluster domain HTH_Tnp_Tc3_1 PF11427.8 ETO10928.1 - 0.97 9.3 3.2 2.9 7.8 0.0 3.1 3 1 0 3 3 3 0 Tc3 transposase WD40 PF00400.32 ETO10930.1 - 1.1e-81 266.6 23.5 6.1e-08 33.2 0.2 14.7 14 0 0 14 14 14 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10930.1 - 2e-21 76.0 12.6 0.032 14.5 0.0 11.6 1 1 9 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO10930.1 - 1.3e-07 31.7 0.0 3.7e-07 30.2 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO10930.1 - 3.5e-06 26.5 4.8 3.5e-06 26.5 4.8 1.9 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO10930.1 - 0.00019 21.5 0.9 0.00062 19.9 0.9 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO10930.1 - 0.00019 22.0 0.6 0.0011 19.5 0.0 2.7 2 0 0 2 2 2 1 AAA domain Pentapeptide_3 PF13576.6 ETO10930.1 - 0.00047 20.3 0.7 0.0011 19.0 0.7 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO10930.1 - 0.0039 17.5 0.0 0.021 15.1 0.0 2.3 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO10930.1 - 0.091 13.3 1.3 0.2 12.2 0.0 2.3 2 0 0 2 2 2 0 ABC transporter PD40 PF07676.12 ETO10930.1 - 0.32 11.0 5.8 0.46 10.5 0.2 4.3 6 0 0 6 6 4 0 WD40-like Beta Propeller Repeat RNA_helicase PF00910.22 ETO10930.1 - 0.4 11.1 3.6 1.3 9.5 0.1 3.6 2 1 0 2 2 2 0 RNA helicase ATPase PF06745.13 ETO10930.1 - 1.3 8.3 0.0 1.3 8.3 0.0 3.5 3 1 0 3 3 3 0 KaiC Chorein_N PF12624.7 ETO10931.1 - 7.7e-27 93.7 0.1 8.5e-27 93.6 0.1 1.0 1 0 0 1 1 1 1 N-terminal region of Chorein or VPS13 Ferlin_C PF16165.5 ETO10932.1 - 0.0076 16.2 1.5 0.0076 16.2 1.5 2.1 2 1 0 2 2 2 1 Ferlin C-terminus DUF3987 PF13148.6 ETO10932.1 - 0.052 12.6 4.8 0.073 12.1 4.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) RAP1 PF07218.11 ETO10932.1 - 0.071 11.4 4.1 0.09 11.0 4.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF1788 PF08747.11 ETO10932.1 - 0.4 10.7 4.8 0.34 10.9 0.7 2.4 1 1 1 3 3 3 0 Domain of unknown function (DUF1788) Pkinase PF00069.25 ETO10935.1 - 3.6e-69 233.1 0.5 3.8e-68 229.7 0.5 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10935.1 - 5.5e-40 137.3 0.5 9.1e-40 136.6 0.2 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO10935.1 - 3.9e-09 36.2 0.0 6.4e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ETO10935.1 - 0.00077 19.1 0.1 0.0014 18.3 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ETO10935.1 - 0.0015 18.5 0.0 0.0025 17.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO10935.1 - 0.0032 16.9 0.6 0.005 16.2 0.2 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO10935.1 - 0.034 13.1 0.2 0.056 12.4 0.2 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO10935.1 - 0.036 12.9 0.0 0.061 12.1 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase DUF1345 PF07077.11 ETO10935.1 - 0.043 13.5 0.0 0.075 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) PRC2_HTH_1 PF18118.1 ETO10936.1 - 0.021 15.6 5.8 0.25 12.2 2.9 2.4 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain AP3D1 PF06375.11 ETO10936.1 - 0.047 13.9 15.1 0.53 10.5 1.1 2.2 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Connexin PF00029.19 ETO10936.1 - 0.38 10.5 8.3 0.096 12.4 1.7 2.1 1 1 1 2 2 2 0 Connexin DUF4574 PF15141.6 ETO10936.1 - 0.65 9.9 4.6 0.67 9.9 0.0 2.7 3 0 0 3 3 3 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 SelK_SelG PF10961.8 ETO10936.1 - 0.88 10.2 0.0 0.88 10.2 0.0 2.8 3 0 0 3 3 3 0 Selenoprotein SelK_SelG MAS20 PF02064.15 ETO10936.1 - 1.3 9.1 9.3 2.3 8.3 0.6 2.2 2 0 0 2 2 2 0 MAS20 protein import receptor Rieske PF00355.26 ETO10938.1 - 2.3e-05 24.2 0.6 8.2e-05 22.5 0.6 2.0 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain DUF4699 PF15770.5 ETO10939.1 - 4.9 6.8 9.3 6.6 6.4 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) Zip PF02535.22 ETO10941.1 - 0.99 8.6 3.1 1.1 8.4 3.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETO10942.1 - 4.5e-18 65.3 13.1 6.7e-06 26.7 0.1 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO10942.1 - 4e-06 25.8 1.8 0.089 11.4 0.0 3.3 3 1 1 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO10942.1 - 0.00037 20.7 0.1 0.31 11.4 0.0 2.8 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PAM2 PF07145.15 ETO10944.1 - 0.00097 18.7 3.7 0.0022 17.5 3.7 1.6 1 0 0 1 1 1 1 Ataxin-2 C-terminal region Choline_kinase PF01633.20 ETO10945.1 - 0.075 12.6 3.5 0.093 12.3 3.5 1.1 1 0 0 1 1 1 0 Choline/ethanolamine kinase DUF325 PF03804.13 ETO10946.1 - 0.024 14.6 0.0 0.063 13.3 0.0 1.7 1 0 0 1 1 1 0 Viral proteins of unknown function Methyltransf_16 PF10294.9 ETO10946.1 - 0.032 14.0 0.4 0.061 13.0 0.4 1.5 1 0 0 1 1 1 0 Lysine methyltransferase DUF4728 PF15860.5 ETO10947.1 - 0.15 12.7 7.1 2.1 9.1 4.0 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4728) WD40 PF00400.32 ETO10950.1 - 3.2e-12 46.7 3.4 3e-05 24.7 0.6 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10950.1 - 0.012 15.9 0.0 5.2 7.4 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10950.1 - 0.021 13.5 0.0 3.2 6.3 0.0 2.0 1 1 0 2 2 2 0 Nucleoporin Nup120/160 TFIIF_alpha PF05793.12 ETO10951.1 - 0.1 11.2 14.4 0.15 10.6 14.4 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4482 PF14818.6 ETO10951.1 - 0.15 12.9 11.8 0.24 12.3 11.6 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) Mga PF05043.13 ETO10951.1 - 0.65 10.6 7.0 0.11 13.0 1.3 2.2 2 0 0 2 2 2 0 Mga helix-turn-helix domain SKA1 PF07160.12 ETO10951.1 - 0.76 9.6 15.4 0.046 13.6 9.1 1.9 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 BUD22 PF09073.10 ETO10951.1 - 0.85 8.9 18.9 1.4 8.2 18.9 1.3 1 1 0 1 1 1 0 BUD22 Cwf_Cwc_15 PF04889.12 ETO10951.1 - 1.5 8.5 23.5 3.1 7.5 23.5 1.5 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETO10951.1 - 1.6 8.0 14.5 2.8 7.2 14.5 1.4 1 0 0 1 1 1 0 NOA36 protein DUF4484 PF14831.6 ETO10951.1 - 2.8 7.9 14.6 19 5.2 14.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4484) Merozoite_SPAM PF07133.11 ETO10952.1 - 0.45 10.5 25.4 0.016 15.2 18.0 1.9 1 1 1 2 2 2 0 Merozoite surface protein (SPAM) LAP1C PF05609.12 ETO10952.1 - 3.8 6.5 20.0 4.6 6.2 20.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 ETO10953.1 - 3.4 6.1 16.5 5.5 5.4 16.5 1.3 1 0 0 1 1 1 0 Macoilin family MIOX PF05153.15 ETO10954.1 - 5.7e-64 216.1 2.8 9.1e-64 215.4 2.8 1.2 1 0 0 1 1 1 1 Myo-inositol oxygenase HDOD PF08668.12 ETO10954.1 - 0.04 13.4 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 HDOD domain HD PF01966.22 ETO10954.1 - 0.053 13.8 0.2 0.13 12.5 0.0 1.7 2 0 0 2 2 2 0 HD domain Fascin PF06268.13 ETO10956.1 - 0.064 13.5 0.3 0.2 11.9 0.1 1.8 2 0 0 2 2 2 0 Fascin domain WD40 PF00400.32 ETO10957.1 - 3.6e-09 37.1 10.4 1.5e-07 32.0 3.0 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10957.1 - 0.049 13.9 0.1 0.48 10.8 0.1 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO10957.1 - 0.05 12.2 0.1 0.3 9.7 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 zf-RING_4 PF14570.6 ETO10959.1 - 1.4 8.7 4.2 2.4 8.0 0.7 2.5 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain PRD_Mga PF08270.11 ETO10960.1 - 0.057 13.1 0.9 1.3 8.6 0.1 2.5 2 1 1 3 3 3 0 M protein trans-acting positive regulator (MGA) PRD domain Raptor_N PF14538.6 ETO10962.1 - 0.00048 20.1 5.5 0.0014 18.6 5.5 1.8 1 1 0 1 1 1 1 Raptor N-terminal CASPase like domain POB3_N PF17292.2 ETO10962.1 - 0.022 15.2 1.1 0.064 13.7 0.6 2.2 1 1 1 2 2 2 0 POB3-like N-terminal PH domain DnaJ PF00226.31 ETO10963.1 - 2.1e-14 53.4 3.0 7.9e-13 48.3 3.0 2.4 1 1 0 1 1 1 1 DnaJ domain 2OG-Fe_Oxy_2 PF10014.9 ETO10963.1 - 0.095 12.5 2.1 0.21 11.4 1.9 1.6 2 0 0 2 2 2 0 2OG-Fe dioxygenase PNP_UDP_1 PF01048.20 ETO10964.1 - 0.0066 15.7 0.0 0.0084 15.4 0.0 1.2 1 0 0 1 1 1 1 Phosphorylase superfamily DUF4130 PF13566.6 ETO10964.1 - 0.063 13.3 2.2 0.19 11.8 2.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4130 FliL PF03748.14 ETO10964.1 - 0.51 11.0 4.6 2.2 8.9 1.5 2.2 1 1 1 2 2 2 0 Flagellar basal body-associated protein FliL Kelch_6 PF13964.6 ETO10967.1 - 0.0088 16.3 0.1 0.13 12.6 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO10967.1 - 0.048 13.7 0.3 10 6.2 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Choline_sulf_C PF12411.8 ETO10968.1 - 0.15 11.9 1.0 0.52 10.1 0.2 2.2 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal RNA_binding PF01877.17 ETO10969.1 - 0.0017 18.6 3.8 0.0051 17.1 0.4 2.0 1 1 1 2 2 2 1 RNA binding MMS19_C PF12460.8 ETO10969.1 - 0.046 12.8 1.3 0.056 12.5 1.3 1.3 1 1 0 1 1 1 0 RNAPII transcription regulator C-terminal PIN_8 PF18476.1 ETO10969.1 - 0.065 13.1 4.0 0.075 12.9 4.0 1.0 1 0 0 1 1 1 0 PIN like domain PWI PF01480.17 ETO10969.1 - 0.066 13.5 0.3 0.96 9.8 0.5 2.1 1 1 1 2 2 2 0 PWI domain LapD_MoxY_N PF16448.5 ETO10969.1 - 0.11 12.4 0.3 0.15 11.9 0.3 1.2 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain VWA_2 PF13519.6 ETO10970.1 - 3.3e-05 24.5 0.6 0.023 15.3 0.3 2.9 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETO10970.1 - 0.0027 18.0 0.1 1.3 9.2 0.0 2.4 2 0 0 2 2 2 2 von Willebrand factor type A domain Ssl1 PF04056.14 ETO10970.1 - 0.082 12.7 0.2 3 7.6 0.0 2.3 2 0 0 2 2 2 0 Ssl1-like VWA_CoxE PF05762.14 ETO10970.1 - 0.15 11.5 0.1 2.9 7.2 0.0 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein TFIIA PF03153.13 ETO10972.1 - 0.088 12.8 14.0 0.11 12.5 14.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Orthopox_F14 PF06076.12 ETO10972.1 - 0.1 12.9 1.9 0.19 12.0 1.9 1.4 1 0 0 1 1 1 0 Orthopoxvirus F14 protein Kelch_6 PF13964.6 ETO10973.1 - 1e-05 25.6 4.5 0.0041 17.4 0.1 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO10973.1 - 1.8e-05 24.5 1.5 0.1 12.6 0.0 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO10973.1 - 1.9e-05 24.1 2.0 0.028 14.0 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO10973.1 - 2.2e-05 24.3 1.7 0.009 16.0 0.1 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO10973.1 - 0.00033 20.9 0.0 0.0055 17.0 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO10973.1 - 0.0017 18.4 0.0 0.023 14.7 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Toprim_3 PF13362.6 ETO10974.1 - 3.1e-18 65.9 0.7 9.7e-18 64.3 0.0 2.3 3 0 0 3 3 3 1 Toprim domain UvrD_C_2 PF13538.6 ETO10974.1 - 0.0029 17.4 0.7 0.0054 16.5 0.7 1.5 1 0 0 1 1 1 1 UvrD-like helicase C-terminal domain Coa1 PF08695.10 ETO10974.1 - 0.038 13.7 0.1 8.3 6.2 0.0 2.8 2 0 0 2 2 2 0 Cytochrome oxidase complex assembly protein 1 DUF1912 PF08930.10 ETO10974.1 - 0.041 14.0 0.3 0.96 9.7 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1912) WD40 PF00400.32 ETO10975.1 - 1.3e-66 218.9 26.9 2.7e-09 37.5 0.1 9.1 9 0 0 9 9 9 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10975.1 - 2.8e-19 69.2 4.2 0.0054 17.0 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10975.1 - 3.2e-14 52.6 0.2 0.028 13.4 0.0 6.2 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO10975.1 - 3.7e-10 39.1 9.5 0.032 12.9 0.1 7.0 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO10975.1 - 2.7e-07 30.2 0.9 0.41 9.9 0.0 3.8 2 1 1 4 4 4 3 WD40-like domain PD40 PF07676.12 ETO10975.1 - 1.7e-05 24.6 6.0 21 5.2 0.1 6.1 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO10975.1 - 1.8e-05 24.3 3.9 0.28 10.5 0.1 4.6 2 2 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal HARP PF07443.13 ETO10975.1 - 0.00094 18.8 0.6 3.7 7.3 0.0 5.4 7 0 0 7 7 7 1 HepA-related protein (HARP) SGL PF08450.12 ETO10975.1 - 0.0013 18.4 0.1 0.055 13.0 0.0 2.9 1 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region DUF1938 PF09153.10 ETO10975.1 - 0.015 15.4 0.1 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1938) DUF3475 PF11961.8 ETO10975.1 - 0.044 13.9 0.3 23 5.2 0.0 3.7 4 1 0 4 4 4 0 Domain of unknown function (DUF3475) Mid2 PF04478.12 ETO10975.1 - 0.095 12.5 0.6 16 5.3 0.0 3.4 3 2 2 5 5 5 0 Mid2 like cell wall stress sensor SecA_DEAD PF07517.14 ETO10976.1 - 7.5e-09 35.3 0.0 2.3e-08 33.7 0.0 1.9 1 1 0 1 1 1 1 SecA DEAD-like domain DUF3891 PF13030.6 ETO10976.1 - 0.027 14.2 0.1 0.061 13.1 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3891) RhoGEF PF00621.20 ETO10979.1 - 4.5e-07 30.3 1.1 6.3e-07 29.8 1.1 1.2 1 0 0 1 1 1 1 RhoGEF domain Exonuc_V_gamma PF04257.14 ETO10979.1 - 0.038 12.2 0.1 0.041 12.1 0.1 1.1 1 0 0 1 1 1 0 Exodeoxyribonuclease V, gamma subunit Kelch_6 PF13964.6 ETO10980.1 - 2.4e-08 34.0 3.5 0.02 15.2 0.1 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO10980.1 - 2.9e-07 30.0 2.3 0.0034 16.9 0.0 4.0 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO10980.1 - 5.7e-07 29.4 4.5 0.057 13.4 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO10980.1 - 1.4e-06 28.0 2.7 0.017 15.1 0.1 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO10980.1 - 7.9e-05 22.8 0.1 0.00054 20.2 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO10980.1 - 0.00011 22.1 0.3 0.00058 19.8 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO10980.1 - 0.0016 17.6 0.1 0.11 11.6 0.0 2.2 2 0 0 2 2 2 1 Protein N-terminal asparagine amidohydrolase TP53IP5 PF15331.6 ETO10981.1 - 0.26 11.4 4.4 0.47 10.6 4.4 1.4 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 zf-C3HC4_5 PF17121.5 ETO10981.1 - 0.72 9.8 9.5 0.24 11.3 5.9 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) BEN PF10523.9 ETO10982.1 - 0.016 15.4 0.4 0.016 15.4 0.4 1.7 2 0 0 2 2 2 0 BEN domain YebO PF13974.6 ETO10982.1 - 8.4 6.6 7.4 1 9.5 0.5 2.1 2 0 0 2 2 2 0 YebO-like protein LRS4 PF10422.9 ETO10986.1 - 2.4 7.7 13.5 3.1 7.3 13.6 1.3 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 EF-hand_7 PF13499.6 ETO10988.1 - 1.8e-14 53.9 3.6 5.8e-10 39.5 0.6 2.8 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO10988.1 - 1.9e-14 52.0 0.5 9.3e-06 24.8 0.0 3.1 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO10988.1 - 6.4e-12 44.4 1.6 6.4e-05 22.6 0.0 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO10988.1 - 1.8e-10 39.8 1.9 9.3e-05 21.7 0.0 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO10988.1 - 2.4e-06 27.3 0.0 9.4e-06 25.4 0.0 2.1 1 1 0 1 1 1 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO10988.1 - 0.0039 17.5 0.1 0.035 14.4 0.0 1.8 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region FDX-ACB PF03147.14 ETO10988.1 - 0.024 15.1 0.5 1.6 9.2 0.0 2.6 2 1 1 3 3 3 0 Ferredoxin-fold anticodon binding domain EF-hand_4 PF12763.7 ETO10988.1 - 0.12 12.4 0.3 0.26 11.3 0.1 1.8 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand PMBR PF09373.10 ETO10988.1 - 0.15 12.3 0.2 3.6 7.9 0.0 2.8 3 0 0 3 3 3 0 Pseudomurein-binding repeat MutL_C PF08676.11 ETO10990.1 - 1.3e-21 76.9 0.0 2.3e-21 76.1 0.0 1.3 1 0 0 1 1 1 1 MutL C terminal dimerisation domain Pkinase PF00069.25 ETO10992.1 - 2e-45 155.2 1.3 3.3e-43 148.0 0.0 3.0 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO10992.1 - 2.7e-22 79.3 0.9 2.3e-21 76.3 0.9 2.8 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO10992.1 - 5.7e-06 25.9 0.0 1e-05 25.0 0.0 1.5 1 1 0 1 1 1 1 Kinase-like Pkinase_C PF00433.24 ETO10992.1 - 0.00082 20.0 2.6 0.0024 18.5 1.9 2.1 2 1 0 2 2 2 1 Protein kinase C terminal domain APH PF01636.23 ETO10992.1 - 0.032 14.1 0.0 0.054 13.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Seadorna_VP7 PF07387.11 ETO10992.1 - 0.068 12.2 0.1 0.2 10.7 0.0 1.6 2 0 0 2 2 2 0 Seadornavirus VP7 Helicase_C PF00271.31 ETO10993.1 - 8.4e-11 42.2 0.1 8.1e-10 39.0 0.1 2.1 1 1 0 1 1 1 1 Helicase conserved C-terminal domain SpoIISA_toxin PF14171.6 ETO10993.1 - 0.12 12.0 2.0 0.22 11.2 2.0 1.4 1 1 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Tudor-knot PF11717.8 ETO10994.1 - 0.018 14.9 0.5 0.041 13.8 0.5 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Aquarius_N PF16399.5 ETO10995.1 - 4.9e-173 577.2 17.9 4.9e-173 577.2 17.9 2.1 2 0 0 2 2 1 1 Intron-binding protein aquarius N-terminus AAA_11 PF13086.6 ETO10995.1 - 8.6e-28 97.8 16.9 7.5e-27 94.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_12 PF13087.6 ETO10995.1 - 7.8e-26 90.9 0.0 7.8e-26 90.9 0.0 3.9 4 0 0 4 4 3 1 AAA domain AAA_19 PF13245.6 ETO10995.1 - 3.5e-08 33.9 0.0 1.7e-07 31.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO10995.1 - 5.8e-07 29.4 0.0 0.0097 15.6 0.0 2.5 2 0 0 2 2 2 2 AAA domain ResIII PF04851.15 ETO10995.1 - 0.00031 20.8 0.1 0.00031 20.8 0.1 3.9 3 1 0 3 3 2 1 Type III restriction enzyme, res subunit AAA PF00004.29 ETO10995.1 - 0.0012 19.3 0.1 0.015 15.7 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) TFIIF_alpha PF05793.12 ETO10995.1 - 0.0012 17.5 21.0 0.0021 16.7 21.0 1.3 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DEAD PF00270.29 ETO10995.1 - 0.0022 17.8 0.0 0.0057 16.5 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO10995.1 - 0.0024 18.2 0.3 0.043 14.1 0.0 3.0 3 0 0 3 3 3 1 AAA domain Viral_helicase1 PF01443.18 ETO10995.1 - 0.0032 17.2 3.8 1.2 8.8 0.0 3.8 4 0 0 4 4 3 1 Viral (Superfamily 1) RNA helicase SAPS PF04499.15 ETO10995.1 - 0.012 14.4 14.9 0.022 13.6 14.9 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein AAA_16 PF13191.6 ETO10995.1 - 0.075 13.4 1.2 0.19 12.1 0.0 2.3 2 1 0 2 2 1 0 AAA ATPase domain AAA_7 PF12775.7 ETO10995.1 - 0.12 11.9 2.0 0.15 11.5 0.1 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region CCDC66 PF15236.6 ETO10995.1 - 0.23 11.3 26.2 0.68 9.8 26.2 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 RNA_helicase PF00910.22 ETO10995.1 - 0.59 10.5 2.5 2.9 8.3 0.0 3.6 5 0 0 5 5 3 0 RNA helicase DDHD PF02862.17 ETO10995.1 - 0.81 9.8 5.9 2.9 8.0 5.9 1.9 1 0 0 1 1 1 0 DDHD domain DUF908 PF06012.12 ETO10995.1 - 2.2 7.6 13.7 7.9 5.8 6.7 2.5 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) Sec62 PF03839.16 ETO10995.1 - 3 7.3 9.6 7.3 6.0 9.6 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 CDC45 PF02724.14 ETO10995.1 - 3 6.0 16.0 5 5.3 16.0 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 ETO10995.1 - 4.7 7.2 10.4 13 5.7 10.4 1.7 1 0 0 1 1 1 0 Protein Family FAM60A CPSF100_C PF13299.6 ETO10995.1 - 5.3 7.2 13.7 17 5.5 13.7 1.9 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Vfa1 PF08432.10 ETO10995.1 - 5.6 7.3 24.4 12 6.2 21.2 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 PPL5 PF18168.1 ETO10995.1 - 7.3 5.8 13.7 16 4.7 13.7 1.5 1 0 0 1 1 1 0 Prim-pol family 5 Exo_endo_phos PF03372.23 ETO10996.1 - 2e-07 30.8 0.0 3.4e-07 30.0 0.0 1.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF2719 PF10891.8 ETO10996.1 - 0.03 14.2 0.1 0.11 12.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2719) SMC_N PF02463.19 ETO10996.1 - 0.078 12.4 0.1 0.087 12.2 0.1 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Ku_C PF03730.14 ETO10996.1 - 0.61 10.8 3.2 0.74 10.5 0.0 2.5 3 0 0 3 3 3 0 Ku70/Ku80 C-terminal arm Mhr1 PF12829.7 ETO10997.1 - 0.00077 19.5 0.2 0.002 18.2 0.2 1.8 1 0 0 1 1 1 1 Transcriptional regulation of mitochondrial recombination MRP-S33 PF08293.11 ETO10997.1 - 0.0018 18.4 0.7 0.004 17.4 0.6 1.7 1 1 0 1 1 1 1 Mitochondrial ribosomal subunit S27 EamA PF00892.20 ETO10998.1 - 1.8 8.7 21.1 1.2 9.3 16.5 2.4 1 1 2 3 3 3 0 EamA-like transporter family DUF2070 PF09843.9 ETO10998.1 - 5 5.3 21.7 6.2 5.0 21.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) WD40 PF00400.32 ETO10999.1 - 3e-62 205.1 15.8 2e-09 37.9 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO10999.1 - 2.6e-25 88.5 0.1 2e-05 24.8 0.0 6.6 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO10999.1 - 5.1e-17 61.8 8.6 0.044 12.7 0.0 7.0 2 2 5 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO10999.1 - 2.6e-11 43.4 0.2 0.0073 15.7 0.0 4.1 2 2 2 4 4 4 3 WD40-like domain Pentapeptide PF00805.22 ETO10999.1 - 1.5e-08 34.1 3.8 0.00013 21.5 0.1 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) eIF2A PF08662.11 ETO10999.1 - 2.6e-07 30.7 0.0 0.18 11.6 0.0 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO10999.1 - 6.4e-07 28.4 1.2 0.019 13.6 0.0 5.1 2 1 3 5 5 5 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO10999.1 - 1.4e-05 24.6 1.6 1.2 8.4 0.0 4.4 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 ETO10999.1 - 0.0011 17.4 0.0 0.064 11.6 0.0 3.1 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO10999.1 - 0.0016 18.3 5.2 0.57 10.2 0.0 5.3 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO10999.1 - 0.0097 16.1 0.3 0.025 14.7 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO10999.1 - 0.18 12.0 4.1 0.31 11.2 1.6 2.7 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO10999.1 - 0.19 11.8 7.1 10 6.2 0.0 4.5 2 2 3 5 5 5 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO11000.1 - 2.2e-26 91.6 17.2 5.6e-07 30.2 2.9 5.7 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11000.1 - 5.5e-10 39.4 1.0 0.0052 17.1 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11000.1 - 1.9e-05 23.6 4.0 0.41 9.2 0.0 3.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 MIR PF02815.19 ETO11000.1 - 0.026 14.4 0.4 0.55 10.0 0.1 2.2 1 1 1 2 2 2 0 MIR domain LydB PF16084.5 ETO11000.1 - 0.027 14.3 0.2 0.98 9.2 0.0 2.3 2 0 0 2 2 2 0 LydA-holin antagonist Connexin PF00029.19 ETO11003.1 - 0.013 15.3 8.2 0.016 14.9 8.2 1.3 1 0 0 1 1 1 0 Connexin DUF913 PF06025.12 ETO11003.1 - 0.023 13.7 1.4 0.025 13.6 1.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RNA_pol_Rpc4 PF05132.14 ETO11003.1 - 0.076 13.4 5.0 0.096 13.1 5.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF2828 PF11443.8 ETO11003.1 - 0.2 9.7 11.7 0.23 9.5 11.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) EOS1 PF12326.8 ETO11003.1 - 0.21 11.5 1.4 0.27 11.2 1.4 1.2 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.17 ETO11003.1 - 0.31 9.8 2.3 0.33 9.7 2.3 1.1 1 0 0 1 1 1 0 Presenilin PPL5 PF18168.1 ETO11003.1 - 0.37 10.1 7.9 0.47 9.7 7.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 HCO3_cotransp PF00955.21 ETO11003.1 - 0.56 9.0 3.3 0.69 8.7 3.3 1.1 1 0 0 1 1 1 0 HCO3- transporter family Zip PF02535.22 ETO11003.1 - 0.56 9.4 1.6 0.61 9.2 1.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CLN3 PF02487.17 ETO11003.1 - 0.69 8.9 2.7 0.82 8.7 2.7 1.1 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 ETO11003.1 - 2.6 7.8 14.8 3.2 7.5 14.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_pol_Rpb1_5 PF04998.17 ETO11003.1 - 6 6.2 8.1 7 6.0 8.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 CLTH PF10607.9 ETO11004.1 - 2.5 8.0 7.4 0.065 13.1 0.3 2.0 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain RAI1 PF08652.11 ETO11006.1 - 9.2e-06 25.8 0.2 0.00011 22.3 0.0 2.2 2 0 0 2 2 2 1 RAI1 like PD-(D/E)XK nuclease DUF5372 PF17342.2 ETO11006.1 - 0.098 13.1 1.5 0.37 11.2 1.5 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5372) U-box PF04564.15 ETO11008.1 - 1.1e-11 44.7 0.0 3.7e-11 43.0 0.0 1.9 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO11008.1 - 0.012 15.7 0.1 0.019 15.1 0.1 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Kelch_6 PF13964.6 ETO11009.1 - 3.8e-07 30.1 3.8 0.006 16.8 0.1 4.0 3 1 1 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ETO11009.1 - 8.2e-05 22.8 0.4 0.0088 16.3 0.0 3.9 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO11009.1 - 0.00033 20.6 0.3 0.036 14.1 0.1 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO11009.1 - 0.0016 18.4 7.4 0.024 14.6 0.7 4.6 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.15 ETO11009.1 - 0.01 15.8 4.6 0.081 12.9 0.4 3.5 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO11009.1 - 0.013 15.1 4.3 0.036 13.7 0.1 2.8 3 0 0 3 3 3 0 Kelch motif C1_2 PF03107.16 ETO11009.1 - 2.9 8.3 6.3 1.3 9.4 3.1 2.2 2 0 0 2 2 2 0 C1 domain Na_Ca_ex PF01699.24 ETO11011.1 - 8.6e-20 71.2 15.5 1.2e-19 70.7 15.5 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein DUF1676 PF07898.13 ETO11011.1 - 0.081 13.0 0.2 0.36 10.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Voldacs PF03517.13 ETO11011.1 - 0.16 12.1 7.1 2.3 8.3 7.1 2.5 2 1 0 2 2 2 0 Regulator of volume decrease after cellular swelling TRAP_alpha PF03896.16 ETO11011.1 - 3.1 6.9 7.4 13 4.8 7.4 1.9 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 ETO11011.1 - 9.6 5.4 8.8 14 4.9 8.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF1774 PF08611.10 ETO11012.1 - 2.3 8.6 9.2 7 7.1 0.2 2.5 2 1 0 2 2 2 0 Fungal protein of unknown function (DUF1774) RelE PF06296.12 ETO11013.1 - 0.038 14.1 0.4 0.068 13.3 0.4 1.4 1 0 0 1 1 1 0 RelE toxin of RelE / RelB toxin-antitoxin system N_Asn_amidohyd PF14736.6 ETO11014.1 - 0.021 14.0 0.1 0.032 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein N-terminal asparagine amidohydrolase tRNA_deacylase PF04414.12 ETO11014.1 - 0.12 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase WD40 PF00400.32 ETO11015.1 - 1.5e-25 88.9 19.7 1.9e-07 31.7 0.8 5.8 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11015.1 - 3.4e-09 36.9 0.4 0.36 11.1 0.0 4.3 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11015.1 - 7.9e-08 32.0 6.2 0.0013 18.1 1.3 3.3 2 1 2 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO11015.1 - 2.3e-07 29.9 1.8 0.021 13.5 0.1 3.2 2 1 1 3 3 3 3 Nucleoporin Nup120/160 CBM65_1 PF18259.1 ETO11015.1 - 0.083 13.0 0.2 7.5 6.7 0.0 2.6 2 1 1 3 3 3 0 Carbohydrate binding module 65 domain 1 ETRAMP PF09716.10 ETO11016.1 - 0.029 14.4 0.5 0.029 14.4 0.5 2.4 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ABC2_membrane_3 PF12698.7 ETO11016.1 - 6.9 5.7 8.1 16 4.4 8.1 1.6 1 1 0 1 1 1 0 ABC-2 family transporter protein FAD_binding_4 PF01565.23 ETO11017.1 - 0.061 13.1 0.0 0.096 12.4 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain HTH_40 PF14493.6 ETO11018.1 - 0.0018 18.7 0.1 0.021 15.3 0.1 2.5 2 0 0 2 2 2 1 Helix-turn-helix domain MIEAP PF16026.5 ETO11019.1 - 0.0003 21.1 0.4 0.00053 20.3 0.4 1.6 1 1 0 1 1 1 1 Mitochondria-eating protein DUF5083 PF16890.5 ETO11019.1 - 0.017 14.8 0.1 0.032 14.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5083) HSP70 PF00012.20 ETO11020.1 - 0.013 13.7 0.0 0.027 12.7 0.0 1.5 1 1 0 1 1 1 0 Hsp70 protein WD40 PF00400.32 ETO11021.1 - 4.9e-36 122.1 25.4 1e-06 29.4 1.0 7.5 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11021.1 - 1.1e-11 44.8 5.7 0.42 10.9 0.0 6.3 4 3 1 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11021.1 - 9.3e-11 41.1 9.4 0.0037 16.0 0.1 5.4 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11021.1 - 1.4e-05 24.6 8.9 0.029 13.7 0.3 5.1 1 1 5 6 6 6 4 WD40-like domain HEAT_2 PF13646.6 ETO11022.1 - 1.5e-14 54.1 5.0 0.007 16.7 0.0 6.6 3 1 6 9 9 9 6 HEAT repeats RTP1_C1 PF10363.9 ETO11022.1 - 4.2e-08 33.4 2.5 0.0066 16.6 0.1 5.4 2 2 3 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 DUF294 PF03445.13 ETO11022.1 - 3.6e-07 30.1 0.3 5e-05 23.1 0.0 3.2 2 0 0 2 2 2 1 Putative nucleotidyltransferase DUF294 DUF294_C PF10335.9 ETO11022.1 - 0.00015 21.6 0.1 0.00065 19.5 0.1 2.2 1 0 0 1 1 1 1 Putative nucleotidyltransferase substrate binding domain HEAT PF02985.22 ETO11022.1 - 0.041 14.1 6.6 9.5 6.8 0.1 5.8 6 0 0 6 6 6 0 HEAT repeat LRR_4 PF12799.7 ETO11022.1 - 0.25 11.8 4.9 1.9 9.0 0.3 4.1 2 1 1 4 4 4 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO11022.1 - 0.31 11.2 2.3 5.9 7.2 0.1 3.5 3 0 0 3 3 3 0 Leucine Rich repeat Vac14_Fab1_bd PF12755.7 ETO11022.1 - 1.6 9.3 5.0 14 6.4 0.0 4.6 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region Ank_4 PF13637.6 ETO11023.1 - 5.7e-14 52.3 1.3 1.5e-06 28.7 0.0 3.6 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO11023.1 - 1.2e-09 38.6 0.6 5.4e-09 36.5 0.6 2.2 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO11023.1 - 5.3e-08 32.5 0.0 0.0014 18.9 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO11023.1 - 1.8e-07 31.3 0.1 3.4e-05 24.0 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO11023.1 - 1e-05 25.7 0.0 0.00019 21.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat DUF4142 PF13628.6 ETO11024.1 - 0.032 14.5 0.7 0.041 14.1 0.1 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4142) RNA_pol_Rpb4 PF03874.16 ETO11024.1 - 0.29 11.5 3.3 0.43 10.9 3.3 1.4 1 1 0 1 1 1 0 RNA polymerase Rpb4 WD40 PF00400.32 ETO11025.1 - 1.3e-12 48.0 9.3 1.1e-07 32.4 0.7 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO11025.1 - 0.00039 19.2 0.2 0.00061 18.6 0.2 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11025.1 - 0.014 15.7 0.0 0.035 14.4 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain RPAP3_C PF13877.6 ETO11026.1 - 1.8e-32 111.7 0.4 1.8e-32 111.7 0.4 2.3 3 0 0 3 3 2 1 Potential Monad-binding region of RPAP3 TPR_1 PF00515.28 ETO11026.1 - 1.8e-18 65.5 7.4 2.2e-05 24.1 0.5 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11026.1 - 7.7e-14 50.6 4.9 0.00022 21.1 0.2 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11026.1 - 2.6e-10 39.8 3.7 8.8e-10 38.1 1.8 2.7 3 0 0 3 3 3 1 TPR repeat TPR_8 PF13181.6 ETO11026.1 - 3.4e-09 36.2 10.4 0.0035 17.4 0.8 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11026.1 - 2e-05 24.6 1.3 9.7e-05 22.5 0.0 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO11026.1 - 0.00066 20.1 0.4 0.005 17.3 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO11026.1 - 0.0019 18.3 0.0 1.3 9.2 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat MIT PF04212.18 ETO11026.1 - 0.031 14.4 3.1 7.9 6.6 0.6 3.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO11026.1 - 0.039 14.8 0.0 1.1 10.2 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11026.1 - 0.085 13.2 1.8 57 4.1 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO11026.1 - 0.16 12.6 0.1 17 6.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11026.1 - 0.43 10.5 1.5 36 4.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat YabA PF06156.13 ETO11026.1 - 6.3 7.5 11.4 1.1 9.9 2.9 3.1 2 0 0 2 2 2 0 Initiation control protein YabA DUF1910 PF08928.10 ETO11026.1 - 9.3 6.3 13.8 1.2 9.2 6.7 3.1 2 1 2 4 4 4 0 Domain of unknown function (DUF1910) DnaJ PF00226.31 ETO11027.1 - 3.3e-29 100.8 4.3 3.3e-29 100.8 4.3 2.5 2 0 0 2 2 2 1 DnaJ domain RPT PF13446.6 ETO11027.1 - 0.033 14.1 0.2 0.083 12.8 0.2 1.7 1 0 0 1 1 1 0 A repeated domain in UCH-protein CDC45 PF02724.14 ETO11027.1 - 0.088 11.1 14.3 0.14 10.4 14.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 ETO11027.1 - 4.1 5.9 17.1 5.7 5.4 17.1 1.1 1 0 0 1 1 1 0 Macoilin family CobT PF06213.12 ETO11027.1 - 5.9 6.2 14.2 10 5.4 14.2 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT adh_short PF00106.25 ETO11028.1 - 6.7e-18 64.8 1.9 9e-18 64.4 1.9 1.1 1 0 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ETO11028.1 - 6.4e-10 38.6 1.7 8.1e-10 38.3 1.7 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ETO11028.1 - 7.4e-07 29.2 0.2 1e-06 28.8 0.2 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO11028.1 - 0.026 14.0 0.2 0.035 13.6 0.2 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family Corona_NS3b PF03053.14 ETO11028.1 - 0.048 13.4 0.0 0.071 12.9 0.0 1.2 1 0 0 1 1 1 0 ORF3b coronavirus protein Mut7-C PF01927.16 ETO11028.1 - 0.094 12.8 0.2 0.12 12.4 0.2 1.2 1 0 0 1 1 1 0 Mut7-C RNAse domain SHP PF03579.13 ETO11028.1 - 0.25 11.3 2.8 0.29 11.1 1.0 2.0 2 0 0 2 2 2 0 Small hydrophobic protein WD40 PF00400.32 ETO11029.1 - 2.2e-09 37.8 0.3 0.002 18.9 0.0 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO11029.1 - 0.047 12.3 0.2 0.44 9.1 0.0 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11029.1 - 0.05 13.9 0.0 0.63 10.4 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain CLASP_N PF12348.8 ETO11030.1 - 6.5e-09 35.7 3.6 7.6e-09 35.5 3.6 1.1 1 0 0 1 1 1 1 CLASP N terminal Nif11 PF07862.11 ETO11031.1 - 0.15 12.4 1.6 0.2 12.0 0.0 2.1 2 1 0 2 2 2 0 Nif11 domain HATPase_c PF02518.26 ETO11032.1 - 7.3e-12 45.8 0.0 1.3e-11 45.0 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO11032.1 - 5.3e-07 29.5 0.0 1.3e-06 28.2 0.0 1.7 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DAG_kinase_N PF14513.6 ETO11032.1 - 0.015 15.5 3.5 0.023 14.9 3.5 1.2 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus FAM60A PF15396.6 ETO11032.1 - 0.055 13.5 1.4 0.077 13.0 1.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A ETRAMP PF09716.10 ETO11032.1 - 0.18 11.8 2.0 0.45 10.6 0.2 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF775 PF05603.12 ETO11034.1 - 0.11 12.0 2.7 0.22 11.1 2.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF775) MAT1 PF06391.13 ETO11034.1 - 0.66 9.8 13.3 0.23 11.3 9.9 2.0 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 SGS PF05002.15 ETO11035.1 - 1.1e-27 95.9 4.0 1.1e-27 95.9 4.0 1.8 2 0 0 2 2 2 1 SGS domain CS PF04969.16 ETO11035.1 - 2.3e-08 35.0 1.2 5.1e-08 33.8 1.2 1.6 1 0 0 1 1 1 1 CS domain Jak1_Phl PF17887.1 ETO11035.1 - 0.76 9.7 8.2 1.2 9.1 0.1 2.5 2 1 0 2 2 2 0 Jak1 pleckstrin homology-like domain Clathrin_H_link PF13838.6 ETO11036.1 - 5.3e-11 42.3 0.6 9.5e-11 41.5 0.6 1.4 1 0 0 1 1 1 1 Clathrin-H-link Kelch_6 PF13964.6 ETO11037.1 - 2.3e-05 24.5 2.3 0.22 11.8 0.1 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO11037.1 - 0.035 13.7 0.9 31 4.3 0.1 3.7 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO11038.1 - 5.8e-06 26.9 0.9 0.00012 22.8 0.1 2.6 2 1 0 2 2 2 1 WD domain, G-beta repeat DUF918 PF06033.11 ETO11038.1 - 0.00062 19.8 2.0 0.00083 19.4 0.6 1.8 1 1 1 2 2 2 1 Nucleopolyhedrovirus protein of unknown function (DUF918) FOP_dimer PF09398.10 ETO11038.1 - 0.054 13.8 0.2 0.69 10.2 0.0 2.2 1 1 1 2 2 2 0 FOP N terminal dimerisation domain Tctex-1 PF03645.13 ETO11039.1 - 3.7e-20 72.1 2.2 3.7e-20 72.1 2.2 2.4 3 0 0 3 3 3 1 Tctex-1 family AAA_5 PF07728.14 ETO11040.1 - 1.3e-19 70.5 0.1 1.1e-08 35.2 0.0 2.6 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO11040.1 - 2e-06 27.4 0.0 5.4e-06 26.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region RuvB_N PF05496.12 ETO11040.1 - 3e-06 27.1 0.4 0.0086 15.8 0.1 2.7 2 1 0 2 2 2 2 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 ETO11040.1 - 8.9e-06 26.3 0.7 0.00022 21.8 0.0 2.7 3 0 0 3 3 2 1 ABC transporter AAA PF00004.29 ETO11040.1 - 3.3e-05 24.3 0.0 0.002 18.5 0.0 2.4 1 1 1 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO11040.1 - 4.4e-05 23.9 0.1 0.00012 22.6 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ETO11040.1 - 5.2e-05 23.1 0.1 0.17 11.6 0.0 2.5 2 1 0 2 2 2 2 AAA domain Sigma54_activ_2 PF14532.6 ETO11040.1 - 7e-05 23.0 0.3 0.0011 19.1 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_22 PF13401.6 ETO11040.1 - 0.00015 22.1 2.9 0.0019 18.5 1.2 2.9 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ETO11040.1 - 0.00068 19.4 0.3 0.0047 16.7 0.0 2.4 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_lid_7 PF17867.1 ETO11040.1 - 0.00079 19.6 0.2 0.0021 18.2 0.2 1.8 1 0 0 1 1 1 1 Midasin AAA lid domain RsgA_GTPase PF03193.16 ETO11040.1 - 0.0037 17.2 0.1 0.014 15.3 0.1 2.0 2 0 0 2 2 1 1 RsgA GTPase AAA_14 PF13173.6 ETO11040.1 - 0.0041 17.2 0.1 0.27 11.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ETO11040.1 - 0.0052 16.9 0.1 3 7.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_21 PF13304.6 ETO11040.1 - 0.0053 16.6 0.1 0.031 14.1 0.0 2.2 3 0 0 3 3 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF815 PF05673.13 ETO11040.1 - 0.0092 15.2 0.3 0.051 12.7 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_18 PF13238.6 ETO11040.1 - 0.0094 16.5 0.2 0.045 14.3 0.0 2.2 3 0 0 3 3 2 1 AAA domain SRP54 PF00448.22 ETO11040.1 - 0.015 14.9 0.0 0.041 13.5 0.0 1.8 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_19 PF13245.6 ETO11040.1 - 0.016 15.6 1.1 0.37 11.1 0.0 2.5 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 ETO11040.1 - 0.016 15.2 0.0 0.053 13.5 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 ETO11040.1 - 0.018 15.0 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_23 PF13476.6 ETO11040.1 - 0.02 15.4 0.3 0.049 14.1 0.0 1.9 2 1 0 2 2 1 0 AAA domain AAA_25 PF13481.6 ETO11040.1 - 0.021 14.4 0.0 0.052 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain Mis12 PF05859.12 ETO11040.1 - 0.023 14.8 0.1 0.084 12.9 0.0 2.0 2 0 0 2 2 1 0 Mis12 protein AAA_29 PF13555.6 ETO11040.1 - 0.028 14.2 0.0 0.058 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ETO11040.1 - 0.03 14.5 0.1 0.083 13.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain NTPase_1 PF03266.15 ETO11040.1 - 0.034 14.1 0.3 2 8.3 0.0 2.6 2 1 0 2 2 2 0 NTPase AAA_6 PF12774.7 ETO11040.1 - 0.035 13.1 0.4 0.14 11.1 0.0 2.2 3 0 0 3 3 2 0 Hydrolytic ATP binding site of dynein motor region ResIII PF04851.15 ETO11040.1 - 0.038 14.0 0.1 0.55 10.2 0.0 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit NACHT PF05729.12 ETO11040.1 - 0.04 13.9 3.8 0.33 10.9 0.4 3.5 3 1 0 3 3 3 0 NACHT domain Mg_chelatase PF01078.21 ETO11040.1 - 0.042 13.2 0.0 0.33 10.3 0.0 2.2 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI T2SSE PF00437.20 ETO11040.1 - 0.043 12.9 0.0 0.074 12.1 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein IstB_IS21 PF01695.17 ETO11040.1 - 0.051 13.3 0.0 0.16 11.7 0.0 1.9 1 1 0 1 1 1 0 IstB-like ATP binding protein PhoH PF02562.16 ETO11040.1 - 0.053 13.0 0.0 0.099 12.1 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein SMC_N PF02463.19 ETO11040.1 - 0.066 12.6 0.1 6.2 6.2 0.1 2.5 2 1 0 2 2 2 0 RecF/RecN/SMC N terminal domain cobW PF02492.19 ETO11040.1 - 0.067 12.8 0.1 0.26 10.9 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_3 PF07726.11 ETO11040.1 - 0.075 12.9 0.7 2 8.3 0.0 2.7 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 ETO11040.1 - 0.11 12.2 0.0 0.25 11.1 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DEAD PF00270.29 ETO11040.1 - 0.11 12.2 0.0 0.23 11.2 0.0 1.8 1 1 0 1 1 1 0 DEAD/DEAH box helicase AAA_8 PF12780.7 ETO11040.1 - 0.12 11.7 2.2 0.29 10.4 0.0 2.6 4 0 0 4 4 3 0 P-loop containing dynein motor region D4 YlqD PF11068.8 ETO11040.1 - 0.29 11.5 1.9 13 6.2 0.1 2.4 2 0 0 2 2 2 0 YlqD protein AAA_lid_7 PF17867.1 ETO11041.1 - 0.04 14.1 0.4 0.058 13.6 0.4 1.4 1 0 0 1 1 1 0 Midasin AAA lid domain G0-G1_switch_2 PF15103.6 ETO11041.1 - 0.04 14.4 0.2 0.071 13.5 0.1 1.5 1 1 1 2 2 2 0 G0/G1 switch protein 2 CDT1_C PF16679.5 ETO11041.1 - 0.042 14.3 2.5 0.07 13.6 2.5 1.4 1 0 0 1 1 1 0 DNA replication factor Cdt1 C-terminal domain Svf1_C PF17187.4 ETO11041.1 - 0.09 12.6 0.0 0.19 11.6 0.0 1.5 1 0 0 1 1 1 0 Svf1-like C-terminal lipocalin-like domain MDM10 PF12519.8 ETO11041.1 - 4.5 6.0 9.3 10 4.9 7.8 1.8 1 1 1 2 2 2 0 Mitochondrial distribution and morphology protein 10 WD40 PF00400.32 ETO11042.1 - 8.2e-38 127.7 33.6 1e-06 29.4 0.8 8.0 7 3 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11042.1 - 1.8e-12 47.4 0.8 0.024 14.9 0.0 5.7 4 1 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11042.1 - 4.7e-07 28.8 7.4 0.17 10.5 0.2 5.6 1 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11042.1 - 0.0025 17.2 5.4 2.9 7.1 0.1 4.6 2 2 2 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO11043.1 - 1.2e-128 415.2 55.9 2.8e-09 37.5 0.3 16.4 16 0 0 16 16 16 16 WD domain, G-beta repeat WD40_like PF17005.5 ETO11043.1 - 6.6e-28 97.9 18.8 8e-05 22.1 0.1 7.9 2 2 6 8 8 8 5 WD40-like domain ANAPC4_WD40 PF12894.7 ETO11043.1 - 1.9e-27 95.4 20.7 0.0086 16.3 0.0 12.7 1 1 14 15 15 15 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11043.1 - 1.2e-17 63.9 11.2 0.23 10.4 1.4 12.1 1 1 11 12 12 12 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Str_synth PF03088.16 ETO11043.1 - 2.2e-06 27.7 2.9 13 6.0 0.0 7.4 7 2 2 9 9 9 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO11043.1 - 6.1e-06 25.0 13.2 0.14 10.6 0.1 5.7 3 1 3 6 6 6 3 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO11043.1 - 0.0032 17.1 0.7 0.0084 15.7 0.7 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) NACHT PF05729.12 ETO11043.1 - 0.048 13.6 0.0 0.094 12.6 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF3475 PF11961.8 ETO11043.1 - 0.18 11.9 0.3 15 5.7 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF3475) PD40 PF07676.12 ETO11043.1 - 4.9 7.2 16.8 75 3.4 0.0 6.9 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat Dicty_CAR PF05462.11 ETO11046.1 - 0.038 13.1 0.0 0.049 12.8 0.0 1.1 1 0 0 1 1 1 0 Slime mold cyclic AMP receptor Peptidase_M20 PF01546.28 ETO11047.1 - 4.5e-20 72.2 0.0 6.6e-20 71.7 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Myc_target_1 PF15179.6 ETO11048.1 - 0.12 12.3 0.5 0.21 11.5 0.5 1.3 1 0 0 1 1 1 0 Myc target protein 1 DUF2603 PF10788.9 ETO11049.1 - 0.035 14.1 0.1 0.043 13.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2603) TPR_12 PF13424.6 ETO11050.1 - 2.5e-57 191.1 13.4 2.3e-13 50.2 0.1 6.1 3 1 2 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11050.1 - 1.4e-40 136.0 2.9 2.1e-06 27.4 0.0 8.9 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11050.1 - 7.9e-38 126.8 39.0 2.5e-07 30.2 0.9 8.3 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11050.1 - 5.8e-27 91.7 15.3 0.0017 18.2 0.2 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11050.1 - 5.7e-24 82.3 49.1 2.9e-05 23.9 0.5 10.8 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11050.1 - 1.1e-22 78.2 35.7 0.00015 21.6 0.3 8.4 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11050.1 - 2.4e-10 39.9 37.0 0.0022 17.7 0.2 9.1 8 3 3 11 11 11 4 TPR repeat ANAPC3 PF12895.7 ETO11050.1 - 2.8e-09 37.1 13.3 0.0042 17.3 0.3 4.8 4 0 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO11050.1 - 7.1e-07 29.8 3.5 0.3 11.8 0.0 6.0 5 2 0 5 5 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11050.1 - 4.4e-06 27.1 2.3 29 5.9 0.1 7.0 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11050.1 - 1.2e-05 25.6 12.7 8.5 7.2 0.1 8.3 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO11050.1 - 1.2e-05 24.8 4.4 0.091 12.1 0.0 3.9 4 1 0 5 5 5 2 MalT-like TPR region TPR_17 PF13431.6 ETO11050.1 - 6.1e-05 23.1 9.2 1.1 9.8 0.1 6.8 5 1 1 6 6 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO11050.1 - 0.00025 20.4 6.6 0.3 10.6 0.0 5.9 7 0 0 7 7 7 1 SHNi-TPR SPO22 PF08631.10 ETO11050.1 - 0.0006 19.4 10.3 0.62 9.5 0.1 4.7 3 2 0 4 4 4 2 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 ETO11050.1 - 0.0085 16.6 4.5 9.1 6.9 0.1 4.5 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF1015 PF06245.11 ETO11050.1 - 0.029 13.2 0.2 0.23 10.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1015) MIT PF04212.18 ETO11050.1 - 0.098 12.7 31.2 2.7 8.1 2.0 8.2 7 1 1 8 8 7 0 MIT (microtubule interacting and transport) domain DUF627 PF04781.12 ETO11050.1 - 0.51 10.4 8.1 11 6.0 0.1 4.5 5 0 0 5 5 5 0 Protein of unknown function (DUF627) Sel1 PF08238.12 ETO11050.1 - 6.5 7.6 17.2 12 6.7 0.1 6.0 6 0 0 6 6 6 0 Sel1 repeat AAA_16 PF13191.6 ETO11051.1 - 0.019 15.4 0.0 0.047 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain Zeta_toxin PF06414.12 ETO11051.1 - 0.022 14.0 0.0 0.047 13.0 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_22 PF13401.6 ETO11051.1 - 0.041 14.2 0.1 0.29 11.4 0.0 2.3 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ETO11051.1 - 0.11 12.4 0.0 0.29 11.0 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase NACHT PF05729.12 ETO11051.1 - 0.17 11.8 0.1 14 5.5 0.0 2.8 2 0 0 2 2 2 0 NACHT domain NOA36 PF06524.12 ETO11052.1 - 0.057 12.7 26.5 0.11 11.9 26.5 1.5 1 0 0 1 1 1 0 NOA36 protein ABC_sub_bind PF04392.12 ETO11053.1 - 2.1e-33 115.8 0.5 4.3e-25 88.6 0.1 2.0 1 1 1 2 2 2 2 ABC transporter substrate binding protein Peripla_BP_6 PF13458.6 ETO11053.1 - 0.054 13.2 0.0 0.074 12.7 0.0 1.3 1 1 0 1 1 1 0 Periplasmic binding protein Peripla_BP_3 PF13377.6 ETO11053.1 - 0.15 12.4 0.0 0.26 11.6 0.0 1.3 1 0 0 1 1 1 0 Periplasmic binding protein-like domain LpxC PF03331.13 ETO11054.1 - 4.1e-59 200.3 0.0 4.6e-59 200.1 0.0 1.0 1 0 0 1 1 1 1 UDP-3-O-acyl N-acetylglycosamine deacetylase DUF3244 PF11589.8 ETO11054.1 - 0.09 12.9 0.8 0.14 12.2 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) Glyco_trans_4_2 PF13477.6 ETO11055.1 - 7.5e-17 61.7 0.5 1e-16 61.3 0.5 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like Glyco_transf_28 PF03033.20 ETO11055.1 - 0.098 12.7 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain Epimerase PF01370.21 ETO11056.1 - 2.1e-57 194.4 0.1 2.5e-57 194.1 0.1 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO11056.1 - 3.9e-48 164.5 0.1 1.1e-47 163.0 0.1 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ETO11056.1 - 2.3e-20 72.8 0.1 2.9e-20 72.4 0.1 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ETO11056.1 - 3.5e-17 62.5 0.2 3.9e-16 59.0 0.2 2.2 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ETO11056.1 - 3.7e-12 45.9 0.0 5.3e-11 42.1 0.0 2.3 1 1 2 3 3 3 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ETO11056.1 - 6.3e-10 38.7 0.2 1.9e-05 24.0 0.0 2.4 2 1 0 2 2 2 2 Male sterility protein adh_short PF00106.25 ETO11056.1 - 1.8e-05 24.3 0.2 9.5e-05 21.9 0.0 2.2 2 1 0 2 2 2 1 short chain dehydrogenase NmrA PF05368.13 ETO11056.1 - 3.3e-05 23.6 0.0 0.0001 22.0 0.0 1.8 2 1 0 2 2 2 1 NmrA-like family NAD_binding_10 PF13460.6 ETO11056.1 - 3.7e-05 23.7 0.0 5.5e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding KR PF08659.10 ETO11056.1 - 4.7e-05 23.4 0.4 0.0009 19.2 0.4 2.5 1 1 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ETO11056.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase Rad9_Rad53_bind PF08605.10 ETO11057.1 - 0.0087 16.3 0.9 3.4 7.9 0.2 2.4 2 0 0 2 2 2 2 Fungal Rad9-like Rad53-binding PUB PF09409.10 ETO11058.1 - 0.0013 18.6 0.0 0.004 17.0 0.0 1.8 1 0 0 1 1 1 1 PUB domain OTU PF02338.19 ETO11058.1 - 0.041 14.4 0.1 0.14 12.7 0.1 1.9 1 0 0 1 1 1 0 OTU-like cysteine protease PanZ PF12568.8 ETO11058.1 - 0.046 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ HJURP_C PF12347.8 ETO11058.1 - 0.095 12.8 2.4 1 9.5 0.7 2.9 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat SNARE PF05739.19 ETO11060.1 - 0.0013 18.6 1.2 0.0025 17.7 0.3 1.9 2 1 0 2 2 2 1 SNARE domain Sec20 PF03908.13 ETO11060.1 - 0.0071 16.2 0.2 0.0089 15.9 0.2 1.3 1 1 0 1 1 1 1 Sec20 APG17 PF04108.12 ETO11060.1 - 0.033 13.3 0.1 0.037 13.1 0.1 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 OAD_gamma PF04277.13 ETO11060.1 - 1.5 9.5 3.3 2.8 8.6 3.3 1.3 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Microtub_bd PF16796.5 ETO11061.1 - 1e-17 64.4 0.5 1e-17 64.4 0.5 2.5 2 1 0 2 2 2 1 Microtubule binding Kinesin PF00225.23 ETO11061.1 - 0.0001 21.3 0.2 0.0001 21.3 0.2 3.2 4 0 0 4 4 4 1 Kinesin motor domain Helicase_C PF00271.31 ETO11062.1 - 4.5e-23 81.7 0.4 1.6e-22 80.0 0.0 1.9 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO11062.1 - 2.2e-10 40.6 2.7 4.8e-10 39.5 0.8 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4082 PF13313.6 ETO11062.1 - 0.033 14.2 0.5 0.045 13.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) TPR_11 PF13414.6 ETO11064.1 - 5.4e-21 74.0 27.5 0.00052 19.6 0.2 5.5 3 2 2 5 5 5 5 TPR repeat TPR_2 PF07719.17 ETO11064.1 - 2.5e-12 45.9 28.2 0.023 14.8 0.4 7.0 6 2 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11064.1 - 4.4e-12 45.5 24.5 0.0034 17.7 1.6 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11064.1 - 2.6e-11 42.8 18.7 0.009 16.2 1.7 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11064.1 - 3e-11 42.6 28.4 0.0035 17.1 2.9 6.4 4 2 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11064.1 - 4.3e-11 42.7 7.4 0.12 13.2 0.3 6.1 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO11064.1 - 2.7e-08 34.3 14.0 0.0051 17.4 2.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO11064.1 - 5.3e-08 33.3 14.8 0.028 14.9 1.5 5.2 2 1 3 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11064.1 - 4.5e-06 26.9 23.7 0.00028 21.1 5.6 5.1 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETO11064.1 - 0.0001 22.4 4.3 0.0045 17.1 0.1 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11064.1 - 0.12 13.0 10.8 64 4.5 0.2 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO11064.1 - 1.3 9.2 11.4 1 9.5 0.1 4.4 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat DUF745 PF05335.13 ETO11064.1 - 1.3 8.7 8.0 2.7 7.7 4.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF745) TPR_7 PF13176.6 ETO11064.1 - 4.4 7.6 12.0 47 4.3 0.1 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat FTA4 PF13093.6 ETO11069.1 - 0.0066 16.4 9.0 0.0099 15.8 9.0 1.3 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Kelch_5 PF13854.6 ETO11069.1 - 0.016 15.2 0.0 7.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO11069.1 - 0.07 13.5 0.0 1.7 9.1 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO11069.1 - 0.11 12.5 0.0 5.5 7.1 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Presenilin PF01080.17 ETO11069.1 - 1.3 7.8 7.4 1.2 7.8 7.4 1.1 1 0 0 1 1 1 0 Presenilin Rsc14 PF08586.10 ETO11069.1 - 5.4 7.9 13.9 30 5.5 3.6 3.2 2 1 1 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit Flagellin_N PF00669.20 ETO11069.1 - 9.9 6.3 14.0 5.1 7.2 4.5 2.2 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region SNARE PF05739.19 ETO11070.1 - 0.02 14.9 3.9 0.05 13.6 3.9 1.7 1 0 0 1 1 1 0 SNARE domain Plasmo_rep PF12135.8 ETO11070.1 - 0.22 11.1 3.5 4.4 6.9 0.1 2.6 2 0 0 2 2 2 0 Plasmodium repeat family Kelch_6 PF13964.6 ETO11071.1 - 1e-07 32.0 4.6 0.0024 18.1 0.5 4.2 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO11071.1 - 1.4e-07 31.4 3.2 0.00038 20.4 0.3 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO11071.1 - 2.3e-07 30.3 2.7 0.00044 19.8 0.4 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO11071.1 - 6.1e-06 26.4 0.8 0.00091 19.5 0.1 3.7 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO11071.1 - 6.1e-06 26.0 2.6 0.0011 18.9 0.5 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO11071.1 - 0.088 12.8 4.6 7.4 6.7 0.3 4.8 6 0 0 6 6 6 0 Kelch motif RasGEF_N PF00618.20 ETO11072.1 - 0.008 16.4 4.4 0.0083 16.3 1.2 2.7 1 1 2 3 3 3 1 RasGEF N-terminal motif ANAPC10 PF03256.16 ETO11072.1 - 0.043 13.4 0.5 0.13 11.9 0.2 1.8 2 0 0 2 2 2 0 Anaphase-promoting complex, subunit 10 (APC10) PPR_2 PF13041.6 ETO11073.1 - 5.2e-17 61.8 14.6 4.9e-09 36.2 0.2 6.0 3 1 3 6 6 6 4 PPR repeat family PPR PF01535.20 ETO11073.1 - 1.2e-16 59.7 6.3 6.9e-05 22.8 0.0 5.0 5 0 0 5 5 5 4 PPR repeat PPR_3 PF13812.6 ETO11073.1 - 9.2e-11 41.7 3.2 0.001 19.1 0.0 4.5 1 1 3 4 4 4 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO11073.1 - 6.9e-10 38.5 7.7 2.3e-05 24.0 0.0 4.7 5 0 0 5 5 5 3 PPR repeat PPR_long PF17177.4 ETO11073.1 - 3.2e-05 23.4 0.0 6.2e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP CAP_N PF01213.19 ETO11074.1 - 0.00052 19.6 5.8 0.00052 19.6 5.8 2.9 3 0 0 3 3 3 1 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 ETO11074.1 - 0.00098 19.2 10.7 0.00098 19.2 10.7 2.5 2 0 0 2 2 2 1 Proline-rich membrane anchor 1 Mito_fiss_reg PF05308.11 ETO11074.1 - 0.0095 16.0 13.5 0.0095 16.0 13.5 2.5 2 0 0 2 2 2 1 Mitochondrial fission regulator Phage_int_SAM_1 PF02899.17 ETO11074.1 - 0.046 14.0 0.8 3.3 8.1 0.6 3.3 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Annexin_like PF18411.1 ETO11074.1 - 0.086 13.1 0.1 0.35 11.2 0.1 2.0 1 0 0 1 1 1 0 Annexin-like domain Nucleoside_tran PF01733.18 ETO11074.1 - 0.18 11.1 1.4 0.47 9.8 1.4 1.7 1 0 0 1 1 1 0 Nucleoside transporter AvrM-A PF18241.1 ETO11074.1 - 0.67 10.4 7.2 0.27 11.6 2.7 2.6 2 0 0 2 2 2 0 Flax-rust effector AvrM-A CENP-B_dimeris PF09026.10 ETO11074.1 - 0.91 9.9 6.9 0.51 10.8 1.1 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain 4HBT_3 PF13622.6 ETO11074.1 - 8.5 6.5 7.8 1.8 8.8 1.8 2.1 2 0 0 2 2 2 0 Thioesterase-like superfamily ANAPC4_WD40 PF12894.7 ETO11075.1 - 4.6e-24 84.5 3.9 0.00014 22.1 0.0 6.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO11075.1 - 1.4e-17 63.7 25.0 2.8e-05 24.8 1.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat WD40_like PF17005.5 ETO11075.1 - 0.0013 18.1 4.2 0.49 9.7 0.0 3.0 3 1 0 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO11075.1 - 0.005 15.4 0.2 2.1 6.8 0.0 2.2 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO11075.1 - 0.0063 16.4 0.0 0.8 9.7 0.0 3.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETO11075.1 - 0.0099 14.2 0.4 1.3 7.2 0.0 2.5 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 ETO11075.1 - 0.028 13.5 3.8 0.2 10.7 0.3 2.6 1 1 2 3 3 3 0 Coatomer WD associated region Clathrin_propel PF01394.20 ETO11075.1 - 0.042 14.2 0.5 0.51 10.8 0.0 2.8 2 1 1 3 3 3 0 Clathrin propeller repeat DUF4116 PF13475.6 ETO11075.1 - 0.11 12.3 0.3 4.6 7.0 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4116) WD40 PF00400.32 ETO11077.1 - 3.8e-05 24.3 0.4 0.00044 21.0 0.3 2.6 3 1 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 ETO11078.1 - 3.1e-15 56.3 12.9 2e-07 31.6 2.9 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11078.1 - 9.5e-07 29.0 0.2 0.00028 21.1 0.1 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11078.1 - 2.4e-05 23.2 0.8 0.0079 14.9 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO11078.1 - 0.026 14.1 3.7 0.053 13.1 3.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4221) Kelch_6 PF13964.6 ETO11079.1 - 2.9e-09 36.9 1.1 0.031 14.6 0.1 4.5 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO11079.1 - 1.1e-08 35.0 0.4 0.00039 20.4 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO11079.1 - 1e-07 31.7 5.0 0.0063 16.5 0.3 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO11079.1 - 4.5e-05 22.9 5.9 0.0089 15.6 0.3 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO11079.1 - 0.0045 17.0 7.4 1.5 8.9 0.2 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ETO11079.1 - 0.018 15.3 2.2 0.19 12.1 0.0 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain NACHT PF05729.12 ETO11080.1 - 0.00017 21.5 0.1 0.0009 19.2 0.1 2.1 1 1 0 1 1 1 1 NACHT domain AHD PF17793.1 ETO11080.1 - 0.057 13.2 2.4 0.64 9.9 0.5 2.9 3 0 0 3 3 3 0 ANC1 homology domain (AHD) NifQ PF04891.12 ETO11080.1 - 1.1 9.6 4.5 8.1 6.8 0.2 2.9 3 0 0 3 3 3 0 NifQ NACHT PF05729.12 ETO11081.1 - 1.5e-09 38.0 0.0 2.7e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO11081.1 - 5e-05 23.9 0.1 0.0023 18.5 0.0 3.4 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO11081.1 - 0.0023 18.2 0.0 0.0088 16.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO11081.1 - 0.018 15.0 0.0 0.055 13.4 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ETO11081.1 - 0.086 13.4 0.1 0.35 11.4 0.1 2.1 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ETO11081.1 - 0.092 13.1 0.8 0.64 10.4 0.1 3.0 2 1 0 2 2 2 0 RNA helicase DUF3387 PF11867.8 ETO11082.1 - 0.027 13.9 0.1 0.029 13.7 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3387) DUF3837 PF12939.7 ETO11082.1 - 0.26 11.7 1.8 3.1 8.3 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3837) Ras PF00071.22 ETO11083.1 - 0.018 14.7 0.3 0.041 13.5 0.0 1.7 2 0 0 2 2 2 0 Ras family Gemini_AL1 PF00799.20 ETO11083.1 - 1.6 9.1 13.3 0.31 11.4 3.3 2.7 2 1 1 3 3 3 0 Geminivirus Rep catalytic domain GTP_EFTU PF00009.27 ETO11084.1 - 5.5e-35 120.7 0.0 8.2e-35 120.1 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ETO11084.1 - 4.7e-22 78.0 0.0 8.8e-22 77.2 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV GTP_EFTU_D2 PF03144.25 ETO11084.1 - 9.6e-09 35.5 0.1 1.9e-08 34.5 0.1 1.5 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_C PF00679.24 ETO11084.1 - 3.4e-06 27.0 0.0 1.2e-05 25.2 0.0 2.1 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ETO11084.1 - 8.1e-06 25.9 0.0 1.5e-05 25.0 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II MMR_HSR1 PF01926.23 ETO11084.1 - 0.0017 18.4 0.0 0.0031 17.6 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ETO11084.1 - 0.037 13.6 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 Ras family SMG1 PF15785.5 ETO11084.1 - 0.14 10.6 0.0 0.22 9.9 0.0 1.2 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 DUF3450 PF11932.8 ETO11085.1 - 3.5e-07 29.8 1.5 6.1e-07 29.0 1.2 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3450) TMF_TATA_bd PF12325.8 ETO11085.1 - 0.00019 21.6 0.5 0.00056 20.1 0.1 1.9 2 0 0 2 2 2 1 TATA element modulatory factor 1 TATA binding TMPIT PF07851.13 ETO11085.1 - 0.00028 20.2 0.3 0.00028 20.2 0.3 2.0 2 0 0 2 2 2 1 TMPIT-like protein Leu_zip PF15294.6 ETO11085.1 - 0.0007 19.2 1.4 0.0013 18.3 1.3 1.4 1 1 0 1 1 1 1 Leucine zipper CENP-F_leu_zip PF10473.9 ETO11085.1 - 0.00084 19.4 0.6 0.00084 19.4 0.6 2.0 3 0 0 3 3 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 NPV_P10 PF05531.12 ETO11085.1 - 0.0013 19.1 0.7 0.0032 17.9 0.5 1.7 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein Filament PF00038.21 ETO11085.1 - 0.003 17.2 0.2 0.0058 16.3 0.2 1.5 1 0 0 1 1 1 1 Intermediate filament protein Rab5-bind PF09311.11 ETO11085.1 - 0.0046 16.4 0.6 0.0076 15.7 0.6 1.3 1 0 0 1 1 1 1 Rabaptin-like protein Laminin_I PF06008.14 ETO11085.1 - 0.0047 16.7 1.5 0.0082 15.9 1.5 1.3 1 0 0 1 1 1 1 Laminin Domain I WXG100 PF06013.12 ETO11085.1 - 0.006 16.8 1.1 0.16 12.2 0.5 2.8 1 1 1 2 2 2 1 Proteins of 100 residues with WXG Tropomyosin PF00261.20 ETO11085.1 - 0.0073 15.7 0.3 0.014 14.8 0.3 1.4 1 0 0 1 1 1 1 Tropomyosin ZapB PF06005.12 ETO11085.1 - 0.0079 16.6 1.5 0.0079 16.6 1.5 2.2 2 1 0 2 2 1 1 Cell division protein ZapB BRE1 PF08647.11 ETO11085.1 - 0.01 15.9 0.5 0.033 14.2 0.3 2.0 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase HAP1_N PF04849.13 ETO11085.1 - 0.023 13.9 0.2 0.034 13.4 0.2 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region bZIP_1 PF00170.21 ETO11085.1 - 0.032 14.3 0.6 6.2 7.0 0.1 3.1 1 1 2 3 3 3 0 bZIP transcription factor BLOC1_2 PF10046.9 ETO11085.1 - 0.033 14.5 0.7 0.091 13.1 0.7 1.8 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fez1 PF06818.15 ETO11085.1 - 0.038 14.4 1.4 0.06 13.8 1.4 1.2 1 0 0 1 1 1 0 Fez1 DUF1664 PF07889.12 ETO11085.1 - 0.041 13.9 2.6 0.25 11.4 0.3 2.5 2 1 1 3 3 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO11085.1 - 0.044 14.3 1.5 0.044 14.3 1.5 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region Claudin_2 PF13903.6 ETO11085.1 - 0.056 13.2 0.0 0.084 12.6 0.0 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction GIT_CC PF16559.5 ETO11085.1 - 0.057 13.3 1.4 0.73 9.7 0.8 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DASH_Dad2 PF08654.10 ETO11085.1 - 0.06 13.8 0.7 0.87 10.0 0.5 2.5 1 1 1 2 2 2 0 DASH complex subunit Dad2 GAS PF13851.6 ETO11085.1 - 0.063 12.6 1.3 0.088 12.2 0.1 1.8 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SlyX PF04102.12 ETO11085.1 - 0.063 13.9 1.3 0.3 11.7 0.6 2.5 1 1 1 2 2 2 0 SlyX Phage_GP20 PF06810.11 ETO11085.1 - 0.066 13.0 1.2 0.2 11.5 1.3 1.8 1 1 0 1 1 1 0 Phage minor structural protein GP20 Phage_holin_3_6 PF07332.11 ETO11085.1 - 0.072 13.1 0.1 0.15 12.1 0.1 1.7 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III DUF4763 PF15960.5 ETO11085.1 - 0.073 12.4 0.1 0.14 11.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) TolA_bind_tri PF16331.5 ETO11085.1 - 0.074 13.1 8.0 1.9 8.6 0.4 3.3 2 1 2 4 4 3 0 TolA binding protein trimerisation DUF4795 PF16043.5 ETO11085.1 - 0.076 12.6 1.6 0.11 12.0 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4618 PF15397.6 ETO11085.1 - 0.081 12.3 0.3 1.7 8.0 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) DivIC PF04977.15 ETO11085.1 - 0.084 12.7 1.5 1.4 8.7 1.1 2.7 1 1 0 1 1 1 0 Septum formation initiator V_ATPase_I PF01496.19 ETO11085.1 - 0.085 10.8 0.3 0.13 10.2 0.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cep57_CLD_2 PF14197.6 ETO11085.1 - 0.093 12.8 1.2 0.22 11.6 1.2 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Laminin_II PF06009.12 ETO11085.1 - 0.1 12.6 0.9 0.38 10.8 0.8 2.0 1 1 1 2 2 2 0 Laminin Domain II HrpB7 PF09486.10 ETO11085.1 - 0.11 12.9 1.0 0.14 12.5 0.2 1.6 2 1 0 2 2 1 0 Bacterial type III secretion protein (HrpB7) Cortex-I_coil PF09304.10 ETO11085.1 - 0.12 12.6 3.5 0.32 11.2 0.9 2.3 2 0 0 2 2 2 0 Cortexillin I, coiled coil DUF5082 PF16888.5 ETO11085.1 - 0.12 12.7 1.8 1.2 9.4 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) dCache_1 PF02743.18 ETO11085.1 - 0.14 11.9 0.3 0.21 11.3 0.3 1.2 1 0 0 1 1 1 0 Cache domain Spc7 PF08317.11 ETO11085.1 - 0.15 10.9 2.3 0.24 10.2 1.3 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein LptF_LptG PF03739.14 ETO11085.1 - 0.18 10.6 2.9 6.1 5.6 0.0 2.2 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG PTS_EIIC PF02378.18 ETO11085.1 - 0.19 10.8 5.5 0.27 10.2 5.5 1.2 1 0 0 1 1 1 0 Phosphotransferase system, EIIC DUF948 PF06103.11 ETO11085.1 - 0.2 12.0 0.6 1.8 8.9 0.6 2.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Baculo_PEP_C PF04513.12 ETO11085.1 - 0.34 10.9 2.4 0.29 11.2 0.8 1.7 2 0 0 2 2 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HIP1_clath_bdg PF16515.5 ETO11085.1 - 0.59 10.8 3.2 1.7 9.3 0.7 2.6 2 1 1 3 3 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 LapA_dom PF06305.11 ETO11085.1 - 0.63 9.9 5.5 0.23 11.3 1.0 2.4 1 1 1 2 2 2 0 Lipopolysaccharide assembly protein A domain Prominin PF05478.11 ETO11085.1 - 2.2 6.1 5.4 1.3 6.9 0.3 2.2 1 1 0 2 2 2 0 Prominin PspB PF06667.12 ETO11085.1 - 2.4 8.3 4.0 8.4 6.5 0.0 2.7 2 0 0 2 2 2 0 Phage shock protein B VIT1 PF01988.19 ETO11085.1 - 8.4 6.2 5.7 8.3 6.2 1.7 2.0 1 1 1 2 2 2 0 VIT family LMBR1 PF04791.16 ETO11086.1 - 1.2e-28 100.3 15.4 1.4e-26 93.5 15.4 2.0 1 1 0 1 1 1 1 LMBR1-like membrane protein DUF3671 PF12420.8 ETO11086.1 - 0.0046 17.0 7.7 0.014 15.4 7.7 1.7 1 0 0 1 1 1 1 Protein of unknown function F-box-like PF12937.7 ETO11087.1 - 0.0002 21.2 1.4 0.00047 20.0 1.4 1.7 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO11087.1 - 0.017 15.0 0.3 0.043 13.7 0.3 1.7 1 0 0 1 1 1 0 F-box domain DUF4710 PF15828.5 ETO11087.1 - 0.03 14.4 3.4 0.03 14.4 3.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) TUSC2 PF15000.6 ETO11088.1 - 0.13 12.5 0.2 0.36 11.1 0.0 1.8 3 0 0 3 3 3 0 Tumour suppressor candidate 2 Zip PF02535.22 ETO11089.1 - 1 8.5 2.7 1.4 8.1 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter EFTUD2 PF16004.5 ETO11090.1 - 2e-26 92.9 4.3 4.2e-26 91.9 4.3 1.4 1 0 0 1 1 1 1 116 kDa U5 small nuclear ribonucleoprotein component N-terminus DHHW PF14286.6 ETO11090.1 - 0.043 13.2 1.2 0.059 12.7 1.2 1.2 1 0 0 1 1 1 0 DHHW protein BSMAP PF12280.8 ETO11090.1 - 0.043 14.0 2.2 0.04 14.1 1.6 1.3 1 1 0 1 1 1 0 Brain specific membrane anchored protein HMG_box_2 PF09011.10 ETO11090.1 - 0.43 11.2 3.8 0.43 11.2 0.3 2.4 3 0 0 3 3 3 0 HMG-box domain WEMBL PF05701.11 ETO11092.1 - 0.0017 17.2 9.4 0.0035 16.1 9.5 1.4 1 1 1 2 2 2 1 Weak chloroplast movement under blue light V_ATPase_I PF01496.19 ETO11092.1 - 0.0087 14.0 3.6 0.011 13.7 3.6 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family SAM_1 PF00536.30 ETO11092.1 - 0.057 13.9 0.2 0.11 13.0 0.2 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO11092.1 - 0.063 13.4 0.2 0.15 12.2 0.2 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF4763 PF15960.5 ETO11092.1 - 0.12 11.7 7.9 0.22 10.8 7.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4763) DUF4407 PF14362.6 ETO11092.1 - 0.18 11.1 3.4 0.23 10.8 3.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 ETO11092.1 - 0.19 11.0 3.9 0.25 10.5 3.9 1.2 1 0 0 1 1 1 0 TMPIT-like protein GAS PF13851.6 ETO11092.1 - 0.19 11.1 12.4 0.32 10.3 10.2 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 ETO11092.1 - 0.29 10.7 4.1 0.33 10.5 4.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Csm1_N PF18504.1 ETO11092.1 - 0.41 11.0 9.4 1.1 9.7 5.1 2.6 2 0 0 2 2 2 0 Csm1 N-terminal domain CENP-F_leu_zip PF10473.9 ETO11092.1 - 0.7 9.9 14.7 1 9.4 13.8 1.8 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PRKG1_interact PF15898.5 ETO11092.1 - 2.4 9.1 11.4 1.9 9.4 9.3 1.8 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain GrpE PF01025.19 ETO11092.1 - 3 7.5 11.2 34 4.1 11.2 2.1 1 1 0 1 1 1 0 GrpE HR1 PF02185.16 ETO11092.1 - 6 7.1 12.0 8.3 6.6 5.6 3.0 2 2 1 3 3 3 0 Hr1 repeat EF-hand_7 PF13499.6 ETO11093.1 - 0.00019 21.8 1.6 0.00051 20.4 0.4 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO11093.1 - 0.0011 18.7 0.5 1.2 9.2 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO11093.1 - 0.0015 18.0 0.7 1.2 8.9 0.1 2.7 2 0 0 2 2 2 2 EF hand SICA_C PF12879.7 ETO11093.1 - 0.024 14.7 0.1 0.06 13.4 0.1 1.7 1 0 0 1 1 1 0 SICA C-terminal inner membrane domain Med9 PF07544.13 ETO11093.1 - 0.036 14.2 1.0 0.036 14.2 1.0 3.1 3 1 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 NOA36 PF06524.12 ETO11093.1 - 0.27 10.5 13.0 0.45 9.8 13.0 1.2 1 0 0 1 1 1 0 NOA36 protein MAP7 PF05672.11 ETO11093.1 - 0.65 9.7 21.9 0.091 12.5 17.0 1.8 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Cwf_Cwc_15 PF04889.12 ETO11093.1 - 2.9 7.5 27.8 0.11 12.2 20.6 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TH1 PF04858.13 ETO11094.1 - 1.7e-06 27.0 0.2 2e-06 26.8 0.2 1.0 1 0 0 1 1 1 1 TH1 protein Ribosomal_L33 PF00471.20 ETO11095.1 - 0.39 11.2 2.9 4.3 7.9 0.0 2.6 2 0 0 2 2 2 0 Ribosomal protein L33 WD40 PF00400.32 ETO11096.1 - 0.0096 16.8 2.2 0.34 11.8 0.0 3.4 4 0 0 4 4 4 1 WD domain, G-beta repeat Mei5_like PF17021.5 ETO11097.1 - 0.31 11.1 6.6 0.25 11.4 1.7 3.1 3 0 0 3 3 3 0 Putative double-strand recombination repair-like Ank_5 PF13857.6 ETO11098.1 - 1.1e-11 44.7 0.0 2.8e-07 30.7 0.0 4.9 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO11098.1 - 4.1e-11 43.3 0.0 1.8e-05 25.2 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO11098.1 - 2.9e-09 36.4 0.0 0.00055 20.2 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ETO11098.1 - 2e-07 31.4 0.0 0.0053 17.3 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ferlin_C PF16165.5 ETO11098.1 - 0.0012 18.9 0.5 0.03 14.3 0.2 2.1 2 0 0 2 2 2 1 Ferlin C-terminus Ank PF00023.30 ETO11098.1 - 0.0022 18.4 0.0 0.025 15.0 0.0 2.5 3 0 0 3 3 3 1 Ankyrin repeat Myosin_head PF00063.21 ETO11099.1 - 2.3e-11 42.7 0.5 3.3e-07 29.0 0.0 2.2 1 1 1 2 2 2 2 Myosin head (motor domain) DUF2815 PF10991.8 ETO11100.1 - 0.016 15.2 0.6 0.029 14.3 0.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2815) IL3Ra_N PF18611.1 ETO11101.1 - 0.076 13.0 0.9 0.1 12.6 0.2 1.6 2 0 0 2 2 2 0 IL-3 receptor alpha chain N-terminal domain Rhabdo_ncap_2 PF03216.13 ETO11103.1 - 0.04 13.4 2.8 2.5 7.5 0.3 2.6 2 1 0 2 2 2 0 Rhabdovirus nucleoprotein Oscp1 PF10188.9 ETO11104.1 - 1.9e-58 197.4 10.3 3.7e-58 196.5 10.3 1.5 1 0 0 1 1 1 1 Organic solute transport protein 1 WD40 PF00400.32 ETO11105.1 - 5.4e-16 58.7 1.0 2e-06 28.4 0.2 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11105.1 - 0.00031 21.0 0.2 0.29 11.5 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain OLF PF02191.16 ETO11105.1 - 0.0043 16.6 0.9 0.039 13.5 0.1 2.0 2 0 0 2 2 2 1 Olfactomedin-like domain Nup160 PF11715.8 ETO11105.1 - 0.0056 15.4 0.1 1.7 7.2 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO11105.1 - 0.0087 16.1 0.3 0.019 15.0 0.3 1.6 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region DHODB_Fe-S_bind PF10418.9 ETO11106.1 - 0.16 11.8 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 Iron-sulfur cluster binding domain of dihydroorotate dehydrogenase B DUF3586 PF12131.8 ETO11107.1 - 1.8 8.8 7.9 0.55 10.5 0.3 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF3586) LSR PF05624.14 ETO11108.1 - 1.2 9.2 8.1 0.09 12.8 2.5 2.0 1 1 1 2 2 2 0 Lipolysis stimulated receptor (LSR) DUF4569 PF15133.6 ETO11109.1 - 0.064 13.0 2.9 0.071 12.8 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) SAPS PF04499.15 ETO11112.1 - 0.027 13.3 4.0 0.035 12.9 4.0 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Mucin PF01456.17 ETO11112.1 - 0.053 13.5 15.3 0.094 12.7 15.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein AAR2 PF05282.11 ETO11112.1 - 0.11 11.9 5.3 0.018 14.5 1.6 1.6 2 0 0 2 2 2 0 AAR2 protein Zip PF02535.22 ETO11112.1 - 0.17 11.1 0.7 0.28 10.3 0.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Dicty_REP PF05086.12 ETO11112.1 - 0.71 7.8 14.6 1 7.2 14.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RP-C_C PF11800.8 ETO11112.1 - 3.5 7.7 8.3 0.91 9.6 5.0 1.6 2 0 0 2 2 2 0 Replication protein C C-terminal region WD40 PF00400.32 ETO11113.1 - 8.5e-12 45.4 10.1 4.7e-06 27.2 0.0 4.0 2 1 1 3 3 3 2 WD domain, G-beta repeat GspL_C PF12693.7 ETO11113.1 - 0.0016 18.3 0.8 0.0025 17.6 0.8 1.3 1 0 0 1 1 1 1 GspL periplasmic domain zf-TRAF PF02176.18 ETO11113.1 - 0.002 18.8 9.4 0.0024 18.5 7.9 1.9 2 0 0 2 2 2 1 TRAF-type zinc finger SH3_13 PF18335.1 ETO11113.1 - 0.0059 16.4 0.1 0.0059 16.4 0.1 3.1 4 0 0 4 4 4 1 ATP-dependent RecD-like DNA helicase SH3 domain DUF641 PF04859.12 ETO11113.1 - 0.01 16.1 12.5 0.31 11.4 3.3 2.4 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) GIT_CC PF16559.5 ETO11113.1 - 0.038 13.9 0.5 0.038 13.9 0.5 2.7 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fez1 PF06818.15 ETO11113.1 - 0.24 11.8 17.6 0.43 11.0 17.6 1.5 1 1 0 1 1 1 0 Fez1 DUF1192 PF06698.11 ETO11113.1 - 0.73 9.9 7.1 13 6.0 0.1 3.3 2 1 0 3 3 3 0 Protein of unknown function (DUF1192) Geminin PF07412.12 ETO11113.1 - 1.3 8.7 19.4 0.42 10.3 5.4 2.9 1 1 2 3 3 3 0 Geminin DUF4407 PF14362.6 ETO11113.1 - 2 7.7 8.9 3 7.1 8.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 ETO11113.1 - 2.7 8.7 19.2 0.44 11.2 6.5 2.7 1 1 1 2 2 2 0 Initiation control protein YabA CC2-LZ PF16516.5 ETO11113.1 - 2.7 8.4 17.1 1 9.7 5.5 2.3 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF16 PF01519.16 ETO11113.1 - 3.8 8.1 25.5 7 7.2 3.1 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 Csm1_N PF18504.1 ETO11113.1 - 4.3 7.7 23.8 4.6 7.6 7.4 3.1 2 1 1 3 3 3 0 Csm1 N-terminal domain PKcGMP_CC PF16808.5 ETO11113.1 - 5 7.1 18.6 0.16 11.8 2.4 3.6 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TMPIT PF07851.13 ETO11113.1 - 5.2 6.2 20.4 2.6 7.2 12.9 2.1 1 1 1 2 2 2 0 TMPIT-like protein DUF4239 PF14023.6 ETO11113.1 - 6.1 6.5 7.1 1.6 8.4 3.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) HIP1_clath_bdg PF16515.5 ETO11113.1 - 7.8 7.2 19.3 3.7 8.2 3.3 2.4 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 WD40 PF00400.32 ETO11115.1 - 3.1e-38 129.1 25.0 7.5e-06 26.6 0.5 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11115.1 - 1.5e-09 38.0 1.6 0.029 14.7 0.0 5.3 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11115.1 - 1.8e-05 23.6 2.9 5.2 5.6 0.0 4.8 2 2 2 4 4 4 4 Nucleoporin Nup120/160 SLR1-BP PF07333.12 ETO11115.1 - 0.04 14.4 0.5 0.12 12.8 0.5 1.8 1 0 0 1 1 1 0 S locus-related glycoprotein 1 binding pollen coat protein (SLR1-BP) DUF443 PF04276.12 ETO11116.1 - 0.66 9.7 0.1 0.66 9.7 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF443) NESP55 PF06390.12 ETO11116.1 - 0.7 9.4 5.9 1 8.9 5.9 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF2714 PF10896.8 ETO11118.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2714) MR_MLE_C PF13378.6 ETO11119.1 - 1.7e-39 135.7 0.0 2.3e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ETO11119.1 - 1.1e-19 70.7 0.0 2.1e-19 69.9 0.0 1.4 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain NACHT PF05729.12 ETO11120.1 - 0.0012 18.8 0.0 0.0026 17.7 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Importin_rep_5 PF18816.1 ETO11120.1 - 0.12 12.7 1.1 0.27 11.6 1.1 1.6 1 0 0 1 1 1 0 Importin repeat U-box PF04564.15 ETO11121.1 - 1.6e-12 47.4 0.0 6.2e-12 45.5 0.0 2.2 1 0 0 1 1 1 1 U-box domain Kelch_1 PF01344.25 ETO11121.1 - 3.2e-05 23.4 0.8 6.3e-05 22.5 0.8 1.5 1 0 0 1 1 1 1 Kelch motif Kelch_6 PF13964.6 ETO11121.1 - 0.00013 22.2 0.6 0.00033 20.8 0.6 1.7 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO11121.1 - 0.0036 17.3 0.1 0.008 16.2 0.1 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain MbeD_MobD PF04899.12 ETO11121.1 - 0.0037 17.3 0.1 0.018 15.1 0.1 2.2 1 1 0 1 1 1 1 MbeD/MobD like Kelch_3 PF13415.6 ETO11121.1 - 0.0062 16.8 0.0 0.014 15.7 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO11121.1 - 0.012 15.6 1.3 0.036 14.1 0.6 2.2 2 0 0 2 2 2 0 Kelch motif ECSIT_C PF14784.6 ETO11121.1 - 0.062 13.6 0.1 0.15 12.4 0.1 1.6 1 0 0 1 1 1 0 C-terminal domain of the ECSIT protein UPF0149 PF03695.13 ETO11121.1 - 0.14 12.4 0.1 0.9 9.8 0.0 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0149) zf-NOSIP PF15906.5 ETO11121.1 - 0.15 12.2 0.0 0.44 10.7 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein CDC45 PF02724.14 ETO11122.1 - 0.0056 15.0 15.9 0.0057 15.0 15.9 1.1 1 0 0 1 1 1 1 CDC45-like protein RR_TM4-6 PF06459.12 ETO11122.1 - 0.42 10.4 7.8 0.52 10.1 7.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPP4R2 PF09184.11 ETO11122.1 - 1.2 8.7 25.2 1.6 8.3 25.2 1.2 1 0 0 1 1 1 0 PPP4R2 SAPS PF04499.15 ETO11122.1 - 1.7 7.3 8.2 1.7 7.3 8.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 ETO11122.1 - 3.4 5.8 31.3 3.8 5.6 31.3 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 ETO11122.1 - 4.8 7.6 5.7 6.3 7.2 5.7 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ank_5 PF13857.6 ETO11123.1 - 6.2e-05 23.2 0.1 0.00023 21.4 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO11123.1 - 0.0012 19.2 0.0 0.011 16.2 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ETO11123.1 - 0.0082 16.5 0.0 0.036 14.5 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO11123.1 - 0.032 14.8 0.4 0.032 14.8 0.4 2.7 2 2 0 2 2 2 0 Ankyrin repeats (3 copies) DUF5384 PF17358.2 ETO11124.1 - 0.11 12.5 0.1 0.14 12.2 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5384) FA_desaturase PF00487.24 ETO11125.1 - 3e-11 43.6 7.5 4.4e-11 43.1 7.5 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DUF4792 PF16040.5 ETO11125.1 - 0.061 13.2 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4792) Ndc1_Nup PF09531.10 ETO11126.1 - 5.6 5.5 12.2 6.7 5.3 12.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Methyltransf_11 PF08241.12 ETO11127.1 - 1.9e-06 28.4 0.0 7.2e-06 26.6 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO11127.1 - 6.8e-06 26.7 0.0 9.1e-05 23.1 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO11127.1 - 0.00033 20.5 0.0 0.00044 20.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ETO11127.1 - 0.04 13.7 0.0 0.053 13.3 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_12 PF08242.12 ETO11127.1 - 0.071 13.9 0.0 0.65 10.8 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain Methyltransf_31 PF13847.6 ETO11127.1 - 0.13 12.1 0.0 0.68 9.7 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 ETO11127.1 - 0.16 12.0 0.0 0.31 11.0 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain TatD_DNase PF01026.21 ETO11128.1 - 3.2e-23 82.4 0.2 4.8e-23 81.8 0.2 1.3 1 1 0 1 1 1 1 TatD related DNase Pkinase PF00069.25 ETO11129.1 - 4.3e-62 209.9 0.8 7.2e-44 150.1 0.0 2.7 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11129.1 - 9.8e-27 93.9 0.0 1.9e-26 92.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO11129.1 - 3.9e-05 22.6 0.0 8.9e-05 21.4 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO11129.1 - 0.058 13.3 0.0 0.17 11.8 0.0 1.7 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ETO11129.1 - 0.072 12.4 0.1 0.17 11.2 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Activator_LAG-3 PF11498.8 ETO11129.1 - 0.17 10.8 0.5 0.28 10.1 0.5 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 PPDFL PF15060.6 ETO11129.1 - 0.22 12.1 1.0 1.3 9.6 0.1 2.6 2 0 0 2 2 2 0 Differentiation and proliferation regulator OAD_gamma PF04277.13 ETO11130.1 - 0.5 11.0 8.2 0.41 11.3 0.4 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ykof PF07615.11 ETO11130.1 - 0.59 10.6 6.9 0.7 10.4 2.0 2.1 2 0 0 2 2 2 0 YKOF-related Family zf-HC5HC2H PF13771.6 ETO11131.1 - 0.02 15.1 2.0 0.02 15.1 2.0 3.0 2 1 1 3 3 3 0 PHD-like zinc-binding domain DUF496 PF04363.12 ETO11131.1 - 1.6 8.8 10.9 0.66 10.0 0.8 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF496) MCM_N PF14551.6 ETO11131.1 - 2.5 8.7 7.1 0.93 10.1 1.4 2.5 1 1 2 3 3 3 0 MCM N-terminal domain Bro-N PF02498.17 ETO11132.1 - 0.12 13.0 2.7 0.16 12.6 0.3 2.3 1 1 1 2 2 2 0 BRO family, N-terminal domain MIEAP PF16026.5 ETO11133.1 - 0.018 15.2 0.1 0.11 12.7 0.1 2.0 1 1 0 1 1 1 0 Mitochondria-eating protein M16C_assoc PF08367.11 ETO11134.1 - 0.0033 16.6 0.1 0.004 16.3 0.1 1.1 1 0 0 1 1 1 1 Peptidase M16C associated Arrestin_C PF02752.22 ETO11134.1 - 0.015 15.7 0.0 0.017 15.6 0.0 1.1 1 0 0 1 1 1 0 Arrestin (or S-antigen), C-terminal domain EF-hand_7 PF13499.6 ETO11134.1 - 0.048 14.1 0.4 0.098 13.1 0.4 1.7 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO11134.1 - 0.048 13.6 0.2 1.6 8.9 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain Tubulin_C PF03953.17 ETO11135.1 - 2.7e-38 131.0 0.0 4e-38 130.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO11135.1 - 0.00013 22.2 0.0 0.00033 20.9 0.0 1.7 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain WD40 PF00400.32 ETO11137.1 - 6.2e-23 80.6 10.4 2.7e-07 31.2 0.5 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11137.1 - 3.2e-08 32.7 1.6 0.007 15.1 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11137.1 - 5.2e-08 33.1 0.0 0.0047 17.2 0.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11137.1 - 0.00055 19.4 0.8 0.005 16.2 0.5 2.2 1 1 0 2 2 2 1 WD40-like domain Peptidase_A22B PF04258.13 ETO11138.1 - 5.8e-46 157.3 14.1 1.4e-45 156.0 14.1 1.6 1 0 0 1 1 1 1 Signal peptide peptidase DUF1467 PF07330.12 ETO11139.1 - 1.1 9.2 4.5 1.3 9.0 1.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1467) Corona_NS3b PF03053.14 ETO11139.1 - 2.6 7.8 12.1 6.9 6.4 6.8 2.2 2 0 0 2 2 2 0 ORF3b coronavirus protein BUD22 PF09073.10 ETO11140.1 - 0.00027 20.4 34.6 0.00056 19.4 34.6 1.5 1 0 0 1 1 1 1 BUD22 TPR_12 PF13424.6 ETO11140.1 - 0.00032 20.9 6.6 4.6 7.6 0.2 6.1 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO11140.1 - 0.0019 18.6 0.1 0.67 10.5 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11140.1 - 0.0032 17.5 12.9 9.4 6.6 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11140.1 - 0.04 13.8 10.7 0.12 12.2 0.3 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11140.1 - 0.064 13.9 0.9 51 4.8 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11140.1 - 0.21 11.7 1.9 34 4.8 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO11140.1 - 0.45 10.8 6.4 3.6 7.9 0.2 3.7 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 MscS_porin PF12795.7 ETO11141.1 - 0.023 14.3 19.6 0.037 13.6 19.6 1.3 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain Phage_capsid PF05065.13 ETO11141.1 - 0.024 13.9 0.9 0.031 13.6 0.9 1.1 1 0 0 1 1 1 0 Phage capsid family Rop-like PF05082.13 ETO11141.1 - 0.041 13.7 1.2 0.069 13.0 0.2 1.9 2 0 0 2 2 2 0 Rop-like AAA_13 PF13166.6 ETO11141.1 - 0.06 12.0 10.7 0.084 11.5 10.7 1.1 1 0 0 1 1 1 0 AAA domain Uteroglobin PF01099.17 ETO11141.1 - 0.085 13.2 0.2 0.22 11.9 0.2 1.6 1 0 0 1 1 1 0 Uteroglobin family YscO PF07321.12 ETO11141.1 - 0.37 10.7 10.6 0.041 13.8 6.1 1.6 2 0 0 2 2 2 0 Type III secretion protein YscO FlxA PF14282.6 ETO11141.1 - 0.45 10.5 26.6 0.68 10.0 6.5 3.1 1 1 2 3 3 3 0 FlxA-like protein V_ATPase_I PF01496.19 ETO11141.1 - 0.48 8.3 8.2 0.57 8.0 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1515 PF07439.11 ETO11141.1 - 0.49 10.5 3.1 0.27 11.3 0.7 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF2203 PF09969.9 ETO11141.1 - 0.98 10.2 6.6 0.86 10.3 4.7 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF4404 PF14357.6 ETO11141.1 - 2.9 8.6 7.8 1.1 9.9 0.9 2.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4404) Efg1 PF10153.9 ETO11141.1 - 3.7 8.0 13.1 5.7 7.3 10.7 2.1 1 1 1 2 2 2 0 rRNA-processing protein Efg1 DUF4407 PF14362.6 ETO11141.1 - 3.8 6.8 12.4 5.1 6.3 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4140 PF13600.6 ETO11141.1 - 6 7.4 8.8 12 6.4 5.8 2.5 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) DUF2408 PF10303.9 ETO11141.1 - 9.5 6.8 11.0 37 4.9 11.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) DUF3619 PF12279.8 ETO11142.1 - 0.34 11.3 2.4 43 4.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3619) Metallophos PF00149.28 ETO11143.1 - 2.8e-11 44.3 0.8 4.2e-11 43.7 0.8 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO11143.1 - 8.8e-08 32.5 1.7 6.5e-06 26.4 1.7 2.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pkinase PF00069.25 ETO11145.1 - 7.2e-11 41.9 0.6 1.4e-09 37.8 0.0 2.4 2 0 0 2 2 2 1 Protein kinase domain NAF PF03822.14 ETO11145.1 - 0.00053 20.1 0.2 0.0018 18.4 0.0 2.0 2 0 0 2 2 2 1 NAF domain KA1 PF02149.19 ETO11145.1 - 0.0043 16.8 0.1 0.0091 15.8 0.1 1.6 1 0 0 1 1 1 1 Kinase associated domain 1 Porph_ging PF09697.10 ETO11146.1 - 8.2 7.0 9.1 9.4 6.9 0.0 4.0 3 0 0 3 3 3 0 Protein of unknown function (Porph_ging) RRF PF01765.19 ETO11147.1 - 9.2e-20 71.2 5.8 9.2e-20 71.2 5.8 1.3 1 1 0 1 1 1 1 Ribosome recycling factor EF-G-binding_N PF07299.11 ETO11147.1 - 0.026 15.1 1.5 0.026 15.1 1.5 2.3 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DsrD PF08679.11 ETO11147.1 - 0.09 13.0 0.6 0.34 11.2 0.5 2.1 1 1 1 2 2 2 0 Dissimilatory sulfite reductase D (DsrD) DUF1870 PF08965.10 ETO11147.1 - 0.21 11.6 1.9 0.38 10.8 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1870) Exo_endo_phos_2 PF14529.6 ETO11148.1 - 0.0011 18.8 0.2 0.0043 16.9 0.2 2.0 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase ATG7_N PF16420.5 ETO11149.1 - 0.0076 15.9 0.2 0.015 15.0 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus SNRNP27 PF08648.12 ETO11150.1 - 0.012 15.6 2.3 0.046 13.8 2.3 1.9 1 0 0 1 1 1 0 U4/U6.U5 small nuclear ribonucleoproteins CooC_C PF15976.5 ETO11150.1 - 0.11 12.6 0.1 0.41 10.7 0.1 2.0 1 1 0 1 1 1 0 CS1-pili formation C-terminal PT PF04886.12 ETO11151.1 - 1.7e-29 101.0 161.5 0.00018 21.0 17.8 9.1 3 2 3 6 6 6 5 PT repeat VWA PF00092.28 ETO11151.1 - 0.0079 16.5 0.0 0.014 15.7 0.0 1.3 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO11151.1 - 0.0085 16.7 0.0 0.014 16.0 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO11152.1 - 0.00052 20.3 0.0 0.00088 19.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DUF1286 PF06939.11 ETO11152.1 - 0.15 12.4 0.0 16 5.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1286) Peptidase_C13 PF01650.18 ETO11153.1 - 4.9e-18 65.6 1.3 1.4e-17 64.1 1.3 1.6 1 1 0 1 1 1 1 Peptidase C13 family PheRS_DBD1 PF18552.1 ETO11153.1 - 0.16 11.7 0.4 0.48 10.2 0.2 1.9 1 1 1 2 2 2 0 PheRS DNA binding domain 1 CRCB PF02537.15 ETO11154.1 - 0.00011 22.4 2.2 0.00018 21.7 2.2 1.6 1 1 0 1 1 1 1 CrcB-like protein, Camphor Resistance (CrcB) PFK PF00365.20 ETO11154.1 - 0.0045 16.3 0.0 0.0045 16.3 0.0 1.1 1 0 0 1 1 1 1 Phosphofructokinase CCSAP PF15748.5 ETO11155.1 - 0.29 11.2 21.2 3.5 7.7 0.1 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Sec62 PF03839.16 ETO11155.1 - 2.3 7.7 20.6 0.3 10.6 1.8 2.6 2 0 0 2 2 2 0 Translocation protein Sec62 BUD22 PF09073.10 ETO11155.1 - 2.4 7.4 38.5 1.8 7.8 3.3 2.1 2 0 0 2 2 2 0 BUD22 FAM60A PF15396.6 ETO11155.1 - 4.7 7.2 20.2 3.6 7.5 8.7 2.3 2 0 0 2 2 2 0 Protein Family FAM60A UPF0564 PF10595.9 ETO11157.1 - 0.046 12.8 6.0 0.059 12.4 6.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 PurS PF02700.14 ETO11158.1 - 0.028 14.6 0.1 0.063 13.5 0.1 1.6 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine (FGAM) synthase Fmp27_GFWDK PF10347.9 ETO11158.1 - 0.036 14.2 0.6 0.064 13.4 0.6 1.4 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2072 PF09845.9 ETO11158.1 - 0.1 12.9 2.3 0.15 12.3 2.3 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein Ldt_C PF17969.1 ETO11159.1 - 0.61 10.8 4.2 2.2 9.0 1.3 3.0 2 1 1 3 3 3 0 L,D-transpeptidase C-terminal domain DUF3873 PF12989.7 ETO11160.1 - 0.045 14.1 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF3873) Glyco_hydro_92 PF07971.12 ETO11162.1 - 0.033 13.1 0.1 0.033 13.1 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 92 Folate_carrier PF01770.18 ETO11163.1 - 0.28 9.9 0.4 0.36 9.5 0.4 1.3 1 0 0 1 1 1 0 Reduced folate carrier WD40 PF00400.32 ETO11164.1 - 6.3e-17 61.7 9.5 3.1e-06 27.8 0.1 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11164.1 - 6.5e-06 25.1 1.1 0.43 9.2 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11164.1 - 2.1e-05 24.7 0.1 0.12 12.6 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11164.1 - 0.00043 19.7 0.7 0.0023 17.3 0.3 2.0 1 1 1 2 2 2 1 WD40-like domain Sulfatase PF00884.23 ETO11165.1 - 2.7e-14 53.3 0.6 3.6e-14 52.9 0.6 1.1 1 0 0 1 1 1 1 Sulfatase DUF908 PF06012.12 ETO11167.1 - 0.074 12.5 0.1 0.074 12.5 0.1 2.0 1 1 1 2 2 2 0 Domain of Unknown Function (DUF908) PPO1_KFDV PF12143.8 ETO11167.1 - 2.2 8.4 6.6 0.21 11.7 2.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF_B2219) LCAT PF02450.15 ETO11168.1 - 7e-70 236.2 0.8 1.2e-53 182.8 1.1 2.7 2 1 0 2 2 2 2 Lecithin:cholesterol acyltransferase Ion_trans PF00520.31 ETO11168.1 - 8.1e-06 25.2 1.6 0.00019 20.8 0.2 2.5 2 0 0 2 2 2 1 Ion transport protein Hva1_TUDOR PF11160.8 ETO11168.1 - 0.17 12.1 0.4 0.33 11.1 0.4 1.5 1 0 0 1 1 1 0 Hypervirulence associated proteins TUDOR domain CENP-B_dimeris PF09026.10 ETO11168.1 - 0.52 10.7 5.2 10 6.6 0.1 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain AChE_tetra PF08674.10 ETO11168.1 - 7.5 6.3 8.7 0.57 9.9 2.2 2.5 2 0 0 2 2 2 0 Acetylcholinesterase tetramerisation domain Corazonin PF17308.2 ETO11168.1 - 9.3 6.6 13.3 2.8 8.3 6.1 2.5 2 0 0 2 2 2 0 Pro-corazonin Aa_trans PF01490.18 ETO11169.1 - 8.7e-17 60.9 15.9 1.1e-16 60.5 15.9 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Pkinase PF00069.25 ETO11170.1 - 8.5e-38 130.2 3.3 1.1e-36 126.5 1.1 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11170.1 - 1.5e-19 70.4 0.2 2.5e-19 69.6 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO11170.1 - 0.00028 19.9 0.0 0.00064 18.8 0.0 1.6 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETO11170.1 - 0.0005 19.5 0.0 0.00095 18.6 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO11170.1 - 0.045 13.1 0.1 0.23 10.7 0.0 2.0 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 ETO11170.1 - 0.049 13.5 0.0 0.092 12.7 0.0 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family PhoLip_ATPase_N PF16209.5 ETO11170.1 - 0.54 10.0 2.0 0.55 10.0 0.0 2.0 2 0 0 2 2 2 0 Phospholipid-translocating ATPase N-terminal RBP_receptor PF14752.6 ETO11171.1 - 0.79 8.2 3.2 0.94 8.0 3.2 1.1 1 0 0 1 1 1 0 Retinol binding protein receptor MCM_bind PF09739.9 ETO11171.1 - 1.6 7.1 6.5 1.7 7.0 6.5 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor UPF0564 PF10595.9 ETO11172.1 - 0.15 11.1 0.1 0.26 10.3 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0564 DUF2457 PF10446.9 ETO11173.1 - 0.19 10.9 5.9 0.27 10.3 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Atrophin-1 PF03154.15 ETO11174.1 - 0.024 13.0 12.8 0.039 12.3 12.8 1.3 1 0 0 1 1 1 0 Atrophin-1 family TMEM247 PF15444.6 ETO11174.1 - 0.054 13.5 1.3 0.059 13.4 0.3 1.5 2 0 0 2 2 2 0 Transmembrane protein 247 DUF5426 PF17473.2 ETO11174.1 - 0.56 10.5 2.0 0.95 9.7 1.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5426) SRP9-21 PF05486.12 ETO11174.1 - 0.91 10.0 7.4 1.1 9.6 1.7 2.9 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) AGO_N PF18236.1 ETO11174.1 - 4.6 7.5 6.6 5.7 7.2 3.0 2.6 2 1 1 3 3 3 0 Argonaute N domain SART-1 PF03343.13 ETO11174.1 - 4.8 5.6 16.8 3.4 6.1 6.0 2.0 2 0 0 2 2 2 0 SART-1 family Beach PF02138.18 ETO11175.1 - 2.4e-46 158.3 0.1 2.4e-46 158.3 0.1 2.2 2 0 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO11175.1 - 2.6e-12 46.7 0.1 2.6e-12 46.7 0.1 2.7 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH DUF3974 PF13120.6 ETO11175.1 - 0.085 13.0 5.6 0.56 10.3 1.1 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3974) LD_cluster3 PF18180.1 ETO11175.1 - 0.16 11.6 1.0 2.2 7.9 1.2 2.3 2 0 0 2 2 2 0 SLOG cluster3 family DUF4704 PF15787.5 ETO11177.1 - 4.5e-13 49.1 0.5 3.7e-05 23.1 0.5 4.1 3 1 0 3 3 3 3 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 ETO11177.1 - 1.7e-06 28.3 0.0 4e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Baculo_11_kDa PF06143.11 ETO11177.1 - 1.2 8.8 4.3 6.7 6.4 4.3 2.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family SAM_2 PF07647.17 ETO11178.1 - 0.0039 17.3 0.6 0.011 15.9 0.6 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO11178.1 - 0.011 16.1 0.7 0.037 14.5 0.7 2.0 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) CLN5 PF15014.6 ETO11178.1 - 0.035 13.8 1.1 3.1 7.4 0.1 2.3 1 1 1 2 2 2 0 Ceroid-lipofuscinosis neuronal protein 5 Zip PF02535.22 ETO11178.1 - 0.35 10.0 1.1 0.41 9.8 1.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO11178.1 - 1.7 6.9 8.5 2.1 6.6 8.5 1.1 1 0 0 1 1 1 0 Menin PDDEXK_6 PF04720.12 ETO11178.1 - 7.7 6.4 6.9 13 5.6 6.9 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function CAP_GLY PF01302.25 ETO11179.1 - 3.8e-11 42.8 0.1 6.8e-11 42.0 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain Hid1 PF12722.7 ETO11179.1 - 0.017 13.3 2.7 0.023 12.9 2.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF3402 PF11882.8 ETO11179.1 - 0.61 9.1 4.5 0.73 8.9 3.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3402) LZ3wCH PF18517.1 ETO11181.1 - 9.2e-12 44.9 1.8 9.2e-12 44.9 1.8 2.4 2 0 0 2 2 2 1 Leucine zipper with capping helix domain Mnd1 PF03962.15 ETO11181.1 - 1.7e-11 44.2 5.4 5.1e-09 36.3 0.1 3.0 3 0 0 3 3 2 2 Mnd1 HTH domain ABC_tran_CTD PF16326.5 ETO11181.1 - 0.00082 19.6 0.4 0.00082 19.6 0.4 2.8 2 1 0 2 2 2 1 ABC transporter C-terminal domain I_LWEQ PF01608.17 ETO11181.1 - 0.0023 18.2 4.3 0.14 12.4 3.1 2.3 2 0 0 2 2 2 1 I/LWEQ domain CCDC-167 PF15188.6 ETO11181.1 - 0.0044 17.3 1.1 0.1 13.0 0.2 2.8 3 0 0 3 3 2 1 Coiled-coil domain-containing protein 167 DUF4094 PF13334.6 ETO11181.1 - 0.0057 17.1 4.2 0.0072 16.7 1.3 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4094) KxDL PF10241.9 ETO11181.1 - 0.006 16.8 2.1 2.1 8.7 0.1 2.4 2 0 0 2 2 2 1 Uncharacterized conserved protein BLOC1_2 PF10046.9 ETO11181.1 - 0.0071 16.6 3.5 0.64 10.4 0.4 2.5 2 0 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 AKNA PF12443.8 ETO11181.1 - 0.012 16.2 0.4 0.034 14.8 0.3 1.7 2 0 0 2 2 1 0 AT-hook-containing transcription factor THOC7 PF05615.13 ETO11181.1 - 0.021 15.1 0.9 0.021 15.1 0.9 2.3 2 0 0 2 2 2 0 Tho complex subunit 7 Tropomyosin PF00261.20 ETO11181.1 - 0.022 14.2 4.3 0.68 9.3 0.2 2.3 2 0 0 2 2 2 0 Tropomyosin Synaptonemal_3 PF15191.6 ETO11181.1 - 0.024 14.4 1.0 0.14 11.9 0.0 2.6 2 1 2 4 4 4 0 Synaptonemal complex central element protein 3 Sugarporin_N PF11471.8 ETO11181.1 - 0.04 13.9 0.4 0.075 13.0 0.4 1.4 1 0 0 1 1 1 0 Maltoporin periplasmic N-terminal extension MscS_porin PF12795.7 ETO11181.1 - 0.051 13.1 1.7 0.06 12.9 0.6 1.6 2 0 0 2 2 2 0 Mechanosensitive ion channel porin domain DASH_Dam1 PF08653.10 ETO11181.1 - 0.067 13.0 0.5 0.63 9.9 0.1 2.4 2 0 0 2 2 2 0 DASH complex subunit Dam1 Uds1 PF15456.6 ETO11181.1 - 0.12 12.5 4.7 0.098 12.8 0.6 2.5 2 1 0 2 2 2 0 Up-regulated During Septation GAS PF13851.6 ETO11181.1 - 0.21 10.9 10.0 2 7.7 9.2 2.3 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding RIC3 PF15361.6 ETO11181.1 - 0.23 11.8 3.7 0.11 12.9 1.0 1.8 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 ZapB PF06005.12 ETO11181.1 - 0.25 11.8 4.7 2.5 8.6 0.9 2.7 3 0 0 3 3 2 0 Cell division protein ZapB PSII_Pbs27 PF13326.6 ETO11181.1 - 0.3 11.4 4.7 2.6 8.4 1.0 2.4 1 1 1 2 2 2 0 Photosystem II Pbs27 DivIC PF04977.15 ETO11181.1 - 0.33 10.7 3.6 0.32 10.8 1.3 2.2 2 0 0 2 2 2 0 Septum formation initiator DASH_Dad2 PF08654.10 ETO11181.1 - 0.43 11.0 5.9 0.53 10.7 1.1 2.5 3 0 0 3 3 2 0 DASH complex subunit Dad2 DUF4618 PF15397.6 ETO11181.1 - 0.99 8.8 7.2 0.82 9.0 3.1 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4618) TMF_DNA_bd PF12329.8 ETO11181.1 - 1.3 9.1 10.2 0.98 9.5 5.4 3.1 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF16 PF01519.16 ETO11181.1 - 1.3 9.5 9.9 3.7 8.1 0.4 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 DUF4140 PF13600.6 ETO11181.1 - 1.6 9.2 6.4 2.4 8.6 3.8 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) AAA_23 PF13476.6 ETO11181.1 - 1.7 9.1 10.5 2.6 8.5 10.3 1.5 1 1 0 1 1 1 0 AAA domain DUF1690 PF07956.11 ETO11181.1 - 3.8 7.9 8.5 5.2 7.5 2.9 2.5 2 1 0 2 2 2 0 Protein of Unknown function (DUF1690) Fib_alpha PF08702.10 ETO11181.1 - 5 7.3 8.6 33 4.6 4.5 2.6 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family APG6_N PF17675.1 ETO11181.1 - 5.7 7.5 10.4 0.86 10.1 4.8 2.3 2 1 0 2 2 2 0 Apg6 coiled-coil region CdvA PF18822.1 ETO11181.1 - 7.1 6.5 11.8 2.1 8.2 0.5 2.8 3 0 0 3 3 3 0 CdvA-like coiled-coil domain Seryl_tRNA_N PF02403.22 ETO11181.1 - 8.7 6.6 11.2 0.24 11.6 0.7 3.0 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Pkinase PF00069.25 ETO11182.1 - 0.00021 20.7 0.0 0.00021 20.7 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Ponericin PF07442.11 ETO11182.1 - 0.029 14.4 0.2 0.057 13.5 0.2 1.4 1 0 0 1 1 1 0 Ponericin HAD_SAK_2 PF18143.1 ETO11183.1 - 1.8e-31 109.3 0.0 3.6e-31 108.4 0.0 1.5 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins Ras PF00071.22 ETO11184.1 - 6e-25 87.7 0.1 6e-25 87.7 0.1 1.4 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO11184.1 - 8.8e-09 35.6 0.9 3e-08 33.9 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO11184.1 - 8.1e-05 22.1 0.2 0.00034 20.1 0.0 1.8 1 1 1 2 2 2 1 ADP-ribosylation factor family DUF745 PF05335.13 ETO11185.1 - 0.0022 17.8 5.2 0.0022 17.8 5.2 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF745) MutS_IV PF05190.18 ETO11185.1 - 0.003 17.9 4.4 0.0059 16.9 4.4 1.4 1 0 0 1 1 1 1 MutS family domain IV Macoilin PF09726.9 ETO11185.1 - 0.0032 16.1 18.6 0.0037 15.9 18.6 1.0 1 0 0 1 1 1 1 Macoilin family Takusan PF04822.13 ETO11185.1 - 0.0067 16.3 6.0 0.0067 16.3 6.0 2.0 3 0 0 3 3 3 1 Takusan FPP PF05911.11 ETO11185.1 - 0.016 13.4 19.2 0.02 13.1 19.2 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil FAM76 PF16046.5 ETO11185.1 - 0.04 13.3 17.5 0.048 13.0 17.5 1.1 1 0 0 1 1 1 0 FAM76 protein DUF812 PF05667.11 ETO11185.1 - 0.044 12.7 17.7 0.055 12.4 17.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MPS2 PF17060.5 ETO11185.1 - 0.86 8.8 11.1 0.69 9.1 10.0 1.4 1 1 0 1 1 1 0 Monopolar spindle protein 2 SlyX PF04102.12 ETO11185.1 - 2.1 9.0 9.5 0.46 11.1 3.1 2.6 2 1 1 3 3 3 0 SlyX Nup160 PF11715.8 ETO11186.1 - 0.011 14.5 0.0 0.012 14.3 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO11186.1 - 0.037 14.9 0.1 0.065 14.1 0.1 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat NOA36 PF06524.12 ETO11191.1 - 0.14 11.4 10.1 0.32 10.3 10.1 1.5 1 0 0 1 1 1 0 NOA36 protein OmpH PF03938.14 ETO11191.1 - 0.15 12.4 7.2 0.41 11.0 7.2 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Sporozoite_P67 PF05642.11 ETO11191.1 - 0.2 9.7 6.4 0.27 9.3 6.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.6 ETO11191.1 - 0.55 10.6 6.0 1.6 9.2 6.0 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LAG1-DNAbind PF09271.11 ETO11191.1 - 0.6 10.7 8.9 1.4 9.6 8.4 1.9 1 1 0 1 1 1 0 LAG1, DNA binding POX PF07526.11 ETO11191.1 - 1.5 9.4 12.1 0.12 12.9 6.3 2.1 1 1 1 2 2 2 0 Associated with HOX DUF2937 PF11157.8 ETO11191.1 - 1.7 8.3 3.4 3.8 7.2 0.8 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2937) CENP-B_dimeris PF09026.10 ETO11191.1 - 2.2 8.7 11.3 4.9 7.6 11.3 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CALM_bind PF16025.5 ETO11191.1 - 2.7 8.5 9.7 3.6 8.1 7.6 2.5 1 1 1 2 2 2 0 Calcium-dependent calmodulin binding Pkinase PF00069.25 ETO11192.1 - 0.00017 21.0 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain SbsC_C PF18058.1 ETO11192.1 - 0.053 13.8 0.1 0.095 12.9 0.1 1.4 1 1 0 1 1 1 0 SbsC C-terminal domain DUF4562 PF15123.6 ETO11192.1 - 0.066 13.2 0.1 0.084 12.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4562) CM_1 PF07736.11 ETO11192.1 - 0.08 13.3 0.0 0.096 13.1 0.0 1.2 1 0 0 1 1 1 0 Chorismate mutase type I RGS PF00615.19 ETO11193.1 - 5.8e-08 33.0 6.2 8.4e-08 32.5 3.4 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain PH_11 PF15413.6 ETO11193.1 - 5.2e-07 30.0 3.9 5.2e-07 30.0 3.9 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH PF00169.29 ETO11193.1 - 1.3e-06 28.9 3.4 7.2e-06 26.5 3.4 2.3 1 0 0 1 1 1 1 PH domain RA PF00788.23 ETO11193.1 - 9e-06 26.2 0.1 2.3e-05 24.9 0.1 1.7 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain PH_4 PF15404.6 ETO11193.1 - 0.0068 16.2 0.8 0.013 15.3 0.1 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain DUF3612 PF12268.8 ETO11193.1 - 0.012 15.8 0.1 5.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3612) RBD PF02196.15 ETO11193.1 - 0.068 13.3 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 Raf-like Ras-binding domain SoxE PF06525.11 ETO11193.1 - 0.17 11.4 0.0 0.47 9.9 0.1 1.7 2 0 0 2 2 2 0 Sulfocyanin (SoxE) domain PH_2 PF08458.10 ETO11193.1 - 0.24 11.8 2.0 0.29 11.5 0.4 2.0 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_8 PF15409.6 ETO11193.1 - 0.84 10.0 6.4 22 5.4 0.0 3.5 3 0 0 3 3 3 0 Pleckstrin homology domain La PF05383.17 ETO11194.1 - 2.3e-18 66.0 0.2 6e-18 64.6 0.2 1.8 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ETO11194.1 - 0.00011 21.9 0.1 0.0078 16.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zinc_ribbon_15 PF17032.5 ETO11194.1 - 1.7 9.4 7.0 3.1 8.6 4.2 2.7 2 1 0 2 2 2 0 zinc-ribbon family CAP_GLY PF01302.25 ETO11195.1 - 5e-13 48.8 0.0 1.2e-12 47.7 0.0 1.7 1 0 0 1 1 1 1 CAP-Gly domain WBP-1 PF11669.8 ETO11195.1 - 0.082 13.5 8.2 0.57 10.8 0.1 4.0 3 1 1 4 4 4 0 WW domain-binding protein 1 ER_lumen_recept PF00810.18 ETO11196.1 - 1.4e-45 155.8 23.7 5.1e-31 108.5 10.8 2.8 2 1 1 3 3 3 2 ER lumen protein retaining receptor Y_phosphatase2 PF03162.13 ETO11197.1 - 2.2e-29 102.2 0.8 4.2e-29 101.2 0.8 1.4 1 0 0 1 1 1 1 Tyrosine phosphatase family TPR_8 PF13181.6 ETO11198.1 - 0.0018 18.3 0.2 0.038 14.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11198.1 - 0.029 14.5 0.2 0.26 11.5 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2095 PF09868.9 ETO11199.1 - 0.13 12.2 1.8 0.11 12.5 0.4 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2095) NUDIX PF00293.28 ETO11200.1 - 1.7e-05 24.9 0.1 4.3e-05 23.6 0.0 1.8 2 1 0 2 2 2 1 NUDIX domain MRP-L46 PF11788.8 ETO11200.1 - 0.11 13.2 8.0 1.1 10.0 0.7 3.3 1 1 2 3 3 3 0 39S mitochondrial ribosomal protein L46 MetOD2 PF18548.1 ETO11200.1 - 0.23 11.6 3.2 0.2 11.8 1.3 2.0 2 0 0 2 2 2 0 Metanogen output domain 2 RRM_1 PF00076.22 ETO11201.1 - 1.7e-22 79.0 0.0 1.9e-16 59.6 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO11201.1 - 0.0035 16.9 0.0 0.0083 15.7 0.0 1.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VirK PF06903.12 ETO11201.1 - 0.07 13.2 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 VirK protein DUF3915 PF13054.6 ETO11201.1 - 0.33 10.9 4.7 0.81 9.7 4.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) EF-hand_8 PF13833.6 ETO11202.1 - 0.00017 21.3 0.1 0.00037 20.3 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 ETO11202.1 - 0.0056 17.1 0.2 0.013 15.9 0.0 1.7 2 0 0 2 2 2 1 EF-hand domain pair ABC2_membrane_3 PF12698.7 ETO11202.1 - 8 5.5 9.4 9.6 5.2 9.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein TIP_N PF12457.8 ETO11203.1 - 0.037 14.4 2.8 0.04 14.3 0.3 2.4 2 0 0 2 2 2 0 Tuftelin interacting protein N terminal MG1 PF17790.1 ETO11203.1 - 0.18 12.3 0.2 0.36 11.3 0.2 1.5 1 0 0 1 1 1 0 Macroglobulin domain MG1 HEAT PF02985.22 ETO11204.1 - 0.053 13.8 0.3 2.9 8.4 0.1 2.8 2 0 0 2 2 2 0 HEAT repeat zf-RING_7 PF02591.15 ETO11204.1 - 0.093 12.9 0.1 0.44 10.8 0.0 2.1 2 0 0 2 2 2 0 C4-type zinc ribbon domain LMBR1 PF04791.16 ETO11204.1 - 0.3 9.9 5.7 0.42 9.4 5.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TCP PF03634.13 ETO11204.1 - 5.5 7.5 13.2 1.3 9.6 9.7 1.6 2 0 0 2 2 2 0 TCP family transcription factor VPS9 PF02204.18 ETO11205.1 - 3.8e-15 56.0 0.0 9.1e-15 54.7 0.0 1.7 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain G-alpha PF00503.20 ETO11207.1 - 3.8e-62 210.5 4.3 4.6e-62 210.2 4.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO11207.1 - 1.7e-06 27.6 1.8 4.2e-06 26.3 1.8 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO11207.1 - 0.00025 20.5 0.4 0.0012 18.2 0.4 2.0 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region DUF5046 PF16465.5 ETO11207.1 - 0.034 13.6 0.1 0.055 12.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5046) TPR_2 PF07719.17 ETO11208.1 - 5.8e-08 32.3 3.2 0.011 15.8 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11208.1 - 7.2e-07 28.8 0.4 0.012 15.5 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11208.1 - 9.4e-06 25.8 0.7 0.052 13.8 0.1 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11208.1 - 0.00038 20.1 0.0 1.1 9.0 0.0 4.3 4 1 1 5 5 5 1 TPR repeat TPR_8 PF13181.6 ETO11208.1 - 0.0038 17.3 3.4 9.3 6.8 0.0 4.9 6 0 0 6 6 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO11208.1 - 0.0094 15.4 0.4 0.21 11.1 0.1 2.6 2 0 0 2 2 2 1 SHNi-TPR TPR_17 PF13431.6 ETO11208.1 - 0.023 15.0 0.1 4.5 7.9 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_20 PF14561.6 ETO11208.1 - 0.064 13.6 0.1 0.37 11.2 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat YcbB PF08664.10 ETO11208.1 - 0.084 12.9 1.1 0.17 11.9 1.1 1.4 1 0 0 1 1 1 0 YcbB domain TPR_7 PF13176.6 ETO11208.1 - 0.085 12.9 0.4 52 4.2 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat MAS20 PF02064.15 ETO11208.1 - 0.16 12.1 8.2 1.1 9.4 0.0 2.5 1 1 1 2 2 2 0 MAS20 protein import receptor TPR_12 PF13424.6 ETO11209.1 - 2.6e-25 88.5 1.1 1.1e-12 48.0 0.3 3.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11209.1 - 4.7e-19 67.6 0.0 5.2e-07 29.3 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11209.1 - 1.7e-17 62.0 1.9 1.4e-06 27.9 0.0 4.2 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11209.1 - 5.9e-16 57.3 17.2 1.3e-07 31.3 0.6 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11209.1 - 9.5e-16 56.9 19.2 8.9e-09 34.8 0.4 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11209.1 - 1.9e-14 52.5 12.5 4.3e-07 29.5 0.1 4.9 4 1 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO11209.1 - 3.1e-08 33.5 0.6 0.016 15.3 0.0 3.0 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO11209.1 - 1.3e-05 25.5 0.5 0.5 11.1 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11209.1 - 0.00023 21.3 6.6 0.15 12.5 0.1 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11209.1 - 0.00025 20.7 12.7 0.0097 15.6 0.2 5.2 4 2 2 6 6 6 1 TPR repeat TPR_MalT PF17874.1 ETO11209.1 - 0.0016 17.9 0.0 0.0034 16.8 0.0 1.5 2 0 0 2 2 2 1 MalT-like TPR region TPR_16 PF13432.6 ETO11209.1 - 0.019 15.6 0.0 7.2 7.4 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11209.1 - 0.033 15.0 0.0 7.6 7.7 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO11209.1 - 0.042 13.8 4.4 1.2 9.2 1.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO11209.1 - 0.063 13.1 5.7 1.5 8.6 0.1 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) DUF627 PF04781.12 ETO11209.1 - 0.086 12.9 0.1 0.25 11.4 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF627) DUF2225 PF09986.9 ETO11209.1 - 0.12 12.1 5.9 0.05 13.3 1.7 2.2 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) NSF PF02071.20 ETO11209.1 - 4 8.6 9.5 16 6.9 0.7 4.5 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat DpnI_C PF17726.1 ETO11210.1 - 0.053 13.6 1.1 1.3 9.2 0.1 2.5 1 1 1 2 2 2 0 Dam-replacing HTH domain TPR_14 PF13428.6 ETO11210.1 - 0.12 13.3 0.1 0.34 11.8 0.0 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11210.1 - 0.21 11.8 1.3 0.68 10.2 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat THAP PF05485.12 ETO11210.1 - 3.8 8.5 8.3 3 8.9 2.2 2.6 1 1 1 2 2 2 0 THAP domain CAP_GLY PF01302.25 ETO11212.1 - 3.8e-15 55.7 0.5 1.1e-14 54.2 0.6 1.7 2 0 0 2 2 2 1 CAP-Gly domain Paz_1 PF18349.1 ETO11212.1 - 2.3 8.2 8.1 3.3 7.7 0.1 3.4 3 0 0 3 3 3 0 PAZ domain DUF4484 PF14831.6 ETO11213.1 - 0.22 11.6 18.1 0.84 9.6 7.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Mucin PF01456.17 ETO11213.1 - 0.35 10.8 28.6 0.06 13.3 20.2 2.6 2 1 0 2 2 2 0 Mucin-like glycoprotein Kinesin PF00225.23 ETO11214.1 - 3e-17 62.6 3.6 3.9e-16 58.9 0.9 2.9 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO11214.1 - 1.7e-11 44.2 0.2 1.4e-08 34.8 0.1 2.6 2 1 1 3 3 3 2 Microtubule binding CK_II_beta PF01214.18 ETO11216.1 - 3e-12 46.7 0.1 4.3e-12 46.2 0.1 1.2 1 0 0 1 1 1 1 Casein kinase II regulatory subunit Ras PF00071.22 ETO11219.1 - 0.056 13.0 0.1 0.092 12.3 0.1 1.5 1 1 0 1 1 1 0 Ras family MIF4G PF02854.19 ETO11222.1 - 2e-05 24.4 2.2 3.8e-05 23.4 2.1 1.7 1 1 0 1 1 1 1 MIF4G domain Kinesin_assoc PF16183.5 ETO11222.1 - 0.019 15.1 0.7 0.045 13.9 0.7 1.6 1 0 0 1 1 1 0 Kinesin-associated DUF3011 PF11218.8 ETO11222.1 - 0.054 13.5 1.0 0.093 12.7 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3011) DUF2052 PF09747.9 ETO11223.1 - 0.0043 17.2 7.1 0.0073 16.5 7.1 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) ALMT PF11744.8 ETO11223.1 - 0.0091 14.9 2.2 0.012 14.4 2.2 1.1 1 0 0 1 1 1 1 Aluminium activated malate transporter IDO PF01231.18 ETO11223.1 - 0.054 12.3 0.2 0.076 11.8 0.2 1.2 1 0 0 1 1 1 0 Indoleamine 2,3-dioxygenase SKA1 PF07160.12 ETO11223.1 - 0.084 12.7 8.2 0.14 12.0 8.2 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Rgp1 PF08737.10 ETO11223.1 - 0.15 11.2 1.5 0.2 10.8 1.5 1.1 1 0 0 1 1 1 0 Rgp1 MAT1 PF06391.13 ETO11223.1 - 0.18 11.6 11.6 0.13 12.1 9.9 1.5 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 ORC_WH_C PF18137.1 ETO11223.1 - 0.22 11.6 3.8 0.43 10.7 3.8 1.4 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF4407 PF14362.6 ETO11223.1 - 0.41 10.0 2.8 0.59 9.4 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CobT PF06213.12 ETO11223.1 - 0.5 9.7 9.7 0.85 8.9 9.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CSRNP_N PF16019.5 ETO11223.1 - 2.5 8.0 8.4 0.56 10.1 0.1 2.3 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus CDC45 PF02724.14 ETO11223.1 - 2.5 6.3 8.4 3.7 5.7 8.4 1.2 1 0 0 1 1 1 0 CDC45-like protein JAB PF01398.21 ETO11224.1 - 5e-18 65.2 0.4 1.2e-17 63.9 0.1 1.9 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Prok-JAB PF14464.6 ETO11224.1 - 0.0013 18.5 0.0 0.0027 17.5 0.0 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain DUF4698 PF15769.5 ETO11224.1 - 0.38 9.8 7.8 0.56 9.2 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Mucin PF01456.17 ETO11224.1 - 2.6 8.0 22.3 4.5 7.3 22.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 ETO11224.1 - 5.9 7.3 11.7 13 6.2 11.7 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SR-25 PF10500.9 ETO11224.1 - 7.9 6.0 12.4 10 5.6 12.4 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3671 PF12420.8 ETO11225.1 - 0.07 13.2 5.8 0.18 11.9 5.8 1.7 1 0 0 1 1 1 0 Protein of unknown function CITED PF04487.12 ETO11225.1 - 0.23 11.5 0.5 0.87 9.6 0.3 1.9 2 0 0 2 2 2 0 CITED B12D PF06522.11 ETO11227.1 - 1.2 9.0 8.4 2 8.3 8.4 1.3 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit HSBP1 PF06825.12 ETO11228.1 - 0.0076 16.1 0.1 0.017 15.0 0.1 1.6 1 0 0 1 1 1 1 Heat shock factor binding protein 1 DUF3768 PF12599.8 ETO11228.1 - 0.035 14.1 0.3 0.17 12.0 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3768) DnaG_DnaB_bind PF08278.11 ETO11228.1 - 0.053 14.1 0.7 0.084 13.5 0.7 1.4 1 1 0 1 1 1 0 DNA primase DnaG DnaB-binding CUE PF02845.16 ETO11228.1 - 0.081 12.6 0.0 0.17 11.6 0.0 1.6 1 0 0 1 1 1 0 CUE domain Armet PF10208.9 ETO11228.1 - 0.14 12.1 7.9 0.18 11.8 1.7 2.0 1 1 1 2 2 2 0 Degradation arginine-rich protein for mis-folding CENP-H PF05837.12 ETO11228.1 - 0.76 10.2 7.6 0.18 12.2 1.8 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) RhoGEF PF00621.20 ETO11229.1 - 0.00074 19.8 0.0 0.002 18.4 0.0 1.7 1 1 0 1 1 1 1 RhoGEF domain Mucin PF01456.17 ETO11230.1 - 0.0019 18.2 26.7 0.0019 18.2 26.7 1.6 2 0 0 2 2 2 1 Mucin-like glycoprotein BAF1_ABF1 PF04684.13 ETO11230.1 - 0.047 12.7 9.2 0.05 12.7 9.2 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor AJAP1_PANP_C PF15298.6 ETO11230.1 - 0.12 12.6 18.1 0.19 11.9 18.1 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus FSA_C PF10479.9 ETO11230.1 - 0.19 9.9 14.3 0.22 9.6 14.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Dicty_REP PF05086.12 ETO11230.1 - 1.7 6.5 15.0 2.4 6.1 15.0 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein ASD2 PF08687.11 ETO11230.1 - 2.2 7.8 4.6 3 7.3 4.6 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 EST1_DNA_bind PF10373.9 ETO11231.1 - 0.93 8.9 4.8 1.4 8.3 4.8 1.3 1 0 0 1 1 1 0 Est1 DNA/RNA binding domain Helicase_C_3 PF13625.6 ETO11232.1 - 5.9e-18 65.2 0.0 9.1e-17 61.4 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF3439 PF11921.8 ETO11233.1 - 6.9 6.7 12.2 1.1 9.2 7.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) EF-hand_1 PF00036.32 ETO11234.1 - 0.00063 19.1 0.2 0.0027 17.1 0.1 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO11234.1 - 0.0027 17.5 0.1 0.011 15.6 0.1 2.0 1 0 0 1 1 1 1 EF-hand domain O-antigen_lig PF13425.6 ETO11234.1 - 0.084 11.7 9.8 0.019 13.8 1.1 2.6 2 1 1 3 3 3 0 O-antigen ligase like membrane protein DUF3915 PF13054.6 ETO11234.1 - 0.1 12.6 13.4 0.3 11.1 3.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) EF-hand_7 PF13499.6 ETO11234.1 - 0.11 12.9 0.3 0.11 12.9 0.3 2.5 3 0 0 3 3 3 0 EF-hand domain pair Auts2 PF15336.6 ETO11234.1 - 5.9 7.0 15.2 1.1 9.3 7.5 2.5 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein DEAD PF00270.29 ETO11236.1 - 7.4e-20 71.4 0.1 2.3e-19 69.8 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO11236.1 - 0.0049 16.9 1.8 0.02 14.9 0.0 2.2 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Polo_box_3 PF18544.1 ETO11236.1 - 0.032 14.9 0.3 0.092 13.4 0.2 1.8 1 1 0 1 1 1 0 Polo box domain SLX9 PF15341.6 ETO11236.1 - 0.87 10.0 10.4 1.8 9.0 10.4 1.4 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 DUF1216 PF06746.11 ETO11238.1 - 0.038 14.0 0.8 0.038 14.0 0.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1216) LIN37 PF15306.6 ETO11238.1 - 0.71 10.1 5.5 1.6 8.9 0.5 2.1 2 0 0 2 2 2 0 LIN37 Rot1 PF10681.9 ETO11239.1 - 0.067 12.7 0.1 0.083 12.4 0.1 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal Holin_BhlA PF10960.8 ETO11239.1 - 0.19 11.7 0.3 0.19 11.7 0.3 2.0 2 1 0 2 2 2 0 BhlA holin family NIF PF03031.18 ETO11240.1 - 3e-36 124.5 0.1 4.7e-36 123.9 0.1 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2608 PF11019.8 ETO11240.1 - 0.07 12.6 0.3 0.84 9.1 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2608) DUF3678 PF12435.8 ETO11242.1 - 0.49 9.8 7.1 1.1 8.6 7.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3678) Wzy_C PF04932.15 ETO11242.1 - 1.5 8.4 6.0 0.22 11.1 0.2 2.4 2 1 0 2 2 2 0 O-Antigen ligase PRTase_2 PF15609.6 ETO11243.1 - 0.2 11.1 0.3 0.58 9.6 0.1 1.8 2 0 0 2 2 2 0 Phosphoribosyl transferase DUF4094 PF13334.6 ETO11243.1 - 0.94 9.9 4.9 14 6.2 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) NPR2 PF06218.11 ETO11244.1 - 3.7e-29 101.8 10.5 1.4e-28 99.9 10.5 1.8 1 1 0 1 1 1 1 Nitrogen permease regulator 2 A_thal_3526 PF09713.10 ETO11244.1 - 4.3 7.7 8.4 5.4 7.3 0.1 3.1 3 0 0 3 3 3 0 Plant protein 1589 of unknown function (A_thal_3526) YdaS_antitoxin PF15943.5 ETO11245.1 - 0.033 14.1 0.1 0.16 11.8 0.0 2.2 2 0 0 2 2 2 0 Putative antitoxin of bacterial toxin-antitoxin system, YdaS/YdaT DUF2407_C PF13373.6 ETO11245.1 - 0.29 11.3 10.7 0.07 13.3 3.7 2.7 3 0 0 3 3 3 0 DUF2407 C-terminal domain E1-E2_ATPase PF00122.20 ETO11246.1 - 7.6e-46 155.9 8.1 7.6e-46 155.9 8.1 3.0 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ETO11246.1 - 4.2e-23 82.7 0.0 1.1e-22 81.4 0.0 1.8 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ETO11246.1 - 0.0084 16.5 0.0 0.028 14.9 0.0 2.0 1 0 0 1 1 1 1 Heavy-metal-associated domain Hydrolase_3 PF08282.12 ETO11246.1 - 0.066 12.9 2.6 0.1 12.3 0.4 2.4 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase HEPN_Toprim_N PF18871.1 ETO11247.1 - 0.065 13.2 0.8 0.37 10.7 0.0 1.8 1 1 1 2 2 2 0 HEPN/Toprim N-terminal domain 1 WD40 PF00400.32 ETO11248.1 - 0.0019 19.0 6.6 6.7 7.8 1.9 4.4 2 1 0 3 3 3 3 WD domain, G-beta repeat MTA_R1 PF17226.2 ETO11249.1 - 0.075 13.2 0.6 2.1 8.6 0.3 2.6 2 1 0 2 2 2 0 MTA R1 domain HopJ PF08888.11 ETO11251.1 - 0.99 9.7 7.1 0.81 9.9 0.6 2.5 2 1 0 2 2 2 0 HopJ type III effector protein Peroxin-3 PF04882.12 ETO11252.1 - 2.9e-05 23.2 4.9 5.5e-05 22.3 4.8 1.6 1 1 0 1 1 1 1 Peroxin-3 DUF4349 PF14257.6 ETO11252.1 - 0.022 14.2 0.0 0.038 13.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) WBP-1 PF11669.8 ETO11252.1 - 0.11 13.1 0.9 1.3 9.7 2.2 2.1 2 0 0 2 2 2 0 WW domain-binding protein 1 Orf78 PF06024.12 ETO11252.1 - 0.23 11.8 4.2 8.4 6.8 0.2 2.7 2 1 0 2 2 2 0 Orf78 (ac78) DUF2956 PF11169.8 ETO11252.1 - 0.58 10.4 7.5 0.86 9.8 0.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) DUF4611 PF15387.6 ETO11252.1 - 1 9.6 16.6 4.9 7.4 5.8 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) EphA2_TM PF14575.6 ETO11252.1 - 2.1 9.3 7.6 2.5 9.1 1.2 3.2 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain TFB6 PF17110.5 ETO11252.1 - 7 6.4 12.3 45 3.7 9.1 2.7 2 1 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DivIC PF04977.15 ETO11253.1 - 0.00034 20.3 4.9 0.00034 20.3 4.9 5.5 5 0 0 5 5 5 2 Septum formation initiator DHR10 PF18595.1 ETO11253.1 - 0.0051 16.9 7.9 0.0051 16.9 7.9 5.3 3 2 2 5 5 5 1 Designed helical repeat protein 10 domain Jnk-SapK_ap_N PF09744.9 ETO11253.1 - 0.012 15.8 20.2 0.012 15.8 20.2 3.5 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 UPF0242 PF06785.11 ETO11253.1 - 4.8 7.2 53.4 0.7 10.0 18.8 3.5 2 1 2 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF4349 PF14257.6 ETO11253.1 - 5.5 6.4 19.6 0.023 14.1 2.6 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4349) Fez1 PF06818.15 ETO11253.1 - 5.8 7.3 40.8 0.42 11.0 15.9 3.9 2 1 1 3 3 3 0 Fez1 FlaC_arch PF05377.11 ETO11253.1 - 8.8 6.8 23.9 0.27 11.7 3.9 4.6 5 1 0 5 5 5 0 Flagella accessory protein C (FlaC) Carboxyl_trans PF01039.22 ETO11254.1 - 4.4e-136 454.4 0.1 4.6e-134 447.7 0.1 2.8 1 1 0 1 1 1 1 Carboxyl transferase domain MdcE PF06833.11 ETO11254.1 - 0.17 11.3 0.5 0.27 10.7 0.0 1.5 2 0 0 2 2 2 0 Malonate decarboxylase gamma subunit (MdcE) Zip PF02535.22 ETO11255.1 - 0.6 9.3 7.0 0.48 9.6 0.1 2.6 3 0 0 3 3 3 0 ZIP Zinc transporter WD40 PF00400.32 ETO11257.1 - 1.4e-64 212.5 13.5 7.1e-10 39.3 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11257.1 - 6.8e-25 87.2 6.3 0.0037 17.5 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11257.1 - 1.1e-16 60.8 0.4 0.0049 15.9 0.0 6.2 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO11257.1 - 3.4e-10 39.2 5.5 0.12 11.0 0.0 5.9 2 2 4 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11257.1 - 8.6e-08 31.9 0.8 0.12 11.6 0.0 3.9 1 1 3 5 5 5 3 WD40-like domain PD40 PF07676.12 ETO11257.1 - 4.5e-06 26.5 6.8 3.1 7.8 0.0 6.2 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO11257.1 - 1.1e-05 25.0 1.5 0.0067 15.8 0.2 3.7 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO11257.1 - 4.9e-05 23.4 3.4 10 6.2 0.1 5.5 1 1 4 5 5 5 1 Family of unknown function (DUF5570) PALB2_WD40 PF16756.5 ETO11257.1 - 0.00078 18.5 8.5 0.16 10.9 0.1 4.5 1 1 4 6 6 6 2 Partner and localizer of BRCA2 WD40 domain Mid2 PF04478.12 ETO11257.1 - 0.00078 19.3 0.4 26 4.6 0.1 4.7 4 1 1 5 5 5 0 Mid2 like cell wall stress sensor Proteasome_A_N PF10584.9 ETO11257.1 - 0.00079 19.0 2.4 7.6 6.3 0.0 4.5 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETO11257.1 - 0.0019 16.8 0.0 0.82 8.1 0.0 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO11257.1 - 0.048 12.5 0.0 15 4.3 0.0 3.1 2 1 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) AlphaC_N PF08829.10 ETO11257.1 - 0.12 12.4 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 Alpha C protein N terminal TPR_12 PF13424.6 ETO11258.1 - 3.9e-36 123.2 8.0 6.4e-14 52.0 0.0 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11258.1 - 1.1e-24 85.2 33.4 8.5e-07 28.5 2.5 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11258.1 - 1.7e-22 78.5 0.0 2e-06 27.5 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11258.1 - 3.5e-20 70.5 5.7 6.6e-05 22.7 0.0 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11258.1 - 5e-19 66.8 25.5 0.0017 18.3 0.2 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11258.1 - 1.6e-10 40.3 35.4 0.0059 16.7 1.8 7.2 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11258.1 - 3.2e-05 24.3 7.1 6 7.7 0.4 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11258.1 - 4.8e-05 23.4 4.3 10 6.8 0.9 6.2 6 1 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11258.1 - 0.0062 17.3 0.0 48 5.2 0.0 4.4 4 1 0 4 4 4 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO11258.1 - 0.013 15.1 0.9 0.96 9.1 0.0 3.8 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain SPO22 PF08631.10 ETO11258.1 - 0.1 12.1 5.8 0.8 9.1 0.8 2.7 2 0 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 ETO11258.1 - 0.14 12.7 0.6 2.9 8.5 0.0 3.2 3 1 2 5 5 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO11258.1 - 7.8 7.3 13.0 40 5.1 1.4 4.6 4 1 0 4 4 4 0 Sel1 repeat NAGLU_C PF12972.7 ETO11259.1 - 1e-85 287.5 0.1 1.3e-85 287.2 0.1 1.2 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU PF05089.12 ETO11259.1 - 7.8e-68 228.9 0.1 1.3e-67 228.2 0.1 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain RWD PF05773.22 ETO11260.1 - 5.1e-24 84.8 1.3 5.1e-24 84.8 1.3 2.2 2 0 0 2 2 2 1 RWD domain DFRP_C PF16543.5 ETO11260.1 - 0.011 16.2 9.4 0.011 16.2 9.4 3.3 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 UQ_con PF00179.26 ETO11260.1 - 0.27 10.9 4.1 0.087 12.5 0.3 2.0 2 0 0 2 2 2 0 Ubiquitin-conjugating enzyme Pkinase PF00069.25 ETO11261.1 - 5.2e-35 121.1 0.4 5.2e-35 121.1 0.4 2.8 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11261.1 - 6.9e-20 71.4 0.9 9.8e-18 64.4 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO11261.1 - 0.0017 17.7 0.0 0.0032 16.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO11261.1 - 0.35 9.8 6.3 0.074 12.0 1.3 2.0 1 1 1 2 2 2 0 Haspin like kinase domain DUF4775 PF16001.5 ETO11261.1 - 1.3 8.3 7.0 1.8 7.9 7.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Benyvirus_14KDa PF07255.11 ETO11261.1 - 3.2 8.0 9.0 0.21 11.8 3.0 2.1 2 1 0 2 2 2 0 Benyvirus 14KDa protein MIT PF04212.18 ETO11262.1 - 1.7e-17 63.2 0.3 3.2e-17 62.4 0.3 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA PF00004.29 ETO11263.1 - 3.2e-17 63.2 0.0 4.3e-17 62.8 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) TIP49 PF06068.13 ETO11263.1 - 3.3e-06 26.5 0.0 3.3e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 ETO11263.1 - 1.7e-05 24.6 0.0 2.1e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 ETO11263.1 - 2.1e-05 24.9 0.0 2.4e-05 24.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_18 PF13238.6 ETO11263.1 - 0.00014 22.4 0.0 0.00017 22.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO11263.1 - 0.00023 21.5 0.0 0.0004 20.7 0.0 1.5 1 0 0 1 1 1 1 RNA helicase AAA_33 PF13671.6 ETO11263.1 - 0.00032 20.9 0.0 0.00042 20.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO11263.1 - 0.00034 20.9 0.0 0.00045 20.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ETO11263.1 - 0.00034 19.8 0.0 0.00037 19.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) RuvB_N PF05496.12 ETO11263.1 - 0.00044 20.0 0.0 0.00044 20.0 0.0 1.2 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO11263.1 - 0.00047 20.2 0.0 0.00063 19.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) Torsin PF06309.11 ETO11263.1 - 0.0018 18.4 0.0 0.0021 18.2 0.0 1.1 1 0 0 1 1 1 1 Torsin AAA_24 PF13479.6 ETO11263.1 - 0.0032 17.2 0.0 0.0042 16.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETO11263.1 - 0.004 16.6 0.0 0.0059 16.0 0.0 1.3 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Parvo_NS1 PF01057.17 ETO11263.1 - 0.0059 15.7 0.0 0.0077 15.4 0.0 1.2 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 ATPase_2 PF01637.18 ETO11263.1 - 0.0062 16.5 0.1 0.027 14.4 0.1 1.9 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_17 PF13207.6 ETO11263.1 - 0.0064 16.9 0.0 0.0083 16.5 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 ETO11263.1 - 0.0074 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 PhoH-like protein NACHT PF05729.12 ETO11263.1 - 0.011 15.6 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain DUF2075 PF09848.9 ETO11263.1 - 0.014 14.6 0.0 0.016 14.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) AAA_7 PF12775.7 ETO11263.1 - 0.015 14.8 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 ETO11263.1 - 0.017 14.8 0.0 0.021 14.5 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain TsaE PF02367.17 ETO11263.1 - 0.026 14.5 0.0 0.028 14.4 0.0 1.1 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 ETO11263.1 - 0.028 13.5 0.0 0.029 13.5 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain AAA_25 PF13481.6 ETO11263.1 - 0.047 13.3 0.0 0.058 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO11263.1 - 0.051 13.8 0.0 0.058 13.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO11263.1 - 0.071 12.8 0.0 0.087 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO11263.1 - 0.12 12.9 0.0 0.14 12.7 0.0 1.2 1 0 0 1 1 1 0 ABC transporter AAA_14 PF13173.6 ETO11263.1 - 0.13 12.3 0.0 0.2 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ETO11263.1 - 0.16 11.3 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA PF00004.29 ETO11264.1 - 4.7e-19 69.1 0.0 5.8e-19 68.8 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) SRP-alpha_N PF04086.13 ETO11265.1 - 4.2 7.2 34.5 5.1 6.9 34.5 1.0 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Menin PF05053.13 ETO11265.1 - 5.5 5.2 24.5 6.5 5.0 24.5 1.0 1 0 0 1 1 1 0 Menin Tau95 PF09734.9 ETO11266.1 - 1.3e-12 48.8 0.3 1.3e-12 48.8 0.3 2.2 2 1 0 2 2 2 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain eIF-5a PF01287.20 ETO11266.1 - 0.086 13.0 0.2 0.5 10.5 0.1 2.1 2 0 0 2 2 2 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold Tau95_N PF17682.1 ETO11267.1 - 1.6 8.9 9.7 12 6.1 6.6 3.1 2 1 0 2 2 2 0 Tau95 Triple barrel domain TRAP_alpha PF03896.16 ETO11267.1 - 9.6 5.3 11.0 0.12 11.5 3.0 1.7 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF4347 PF14252.6 ETO11268.1 - 0.082 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) Thioredoxin_15 PF18403.1 ETO11268.1 - 0.78 9.6 7.5 0.56 10.1 0.7 2.0 1 1 1 2 2 2 0 Thioredoxin-like domain Toprim PF01751.22 ETO11268.1 - 0.97 9.7 5.3 0.15 12.3 1.5 1.6 1 1 1 2 2 2 0 Toprim domain Sec62 PF03839.16 ETO11269.1 - 1.3 8.5 8.5 1.5 8.3 8.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 LAT PF15234.6 ETO11270.1 - 0.05 13.3 2.4 0.084 12.6 2.4 1.3 1 0 0 1 1 1 0 Linker for activation of T-cells DUF4042 PF13251.6 ETO11271.1 - 7.5e-18 64.9 2.0 4.8e-09 36.2 0.1 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4042) HEAT PF02985.22 ETO11271.1 - 0.0017 18.5 1.1 1.4 9.4 0.0 3.6 4 0 0 4 4 4 2 HEAT repeat DUF3385 PF11865.8 ETO11271.1 - 0.097 12.6 1.3 14 5.5 0.0 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 ETO11271.1 - 0.15 12.5 0.0 17 5.9 0.0 2.9 2 0 0 2 2 2 0 HEAT repeats Vfa1 PF08432.10 ETO11272.1 - 0.015 15.7 15.7 0.039 14.3 15.7 1.9 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Tim54 PF11711.8 ETO11272.1 - 0.015 14.1 8.3 0.024 13.4 8.3 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 VIR_N PF15912.5 ETO11272.1 - 0.93 9.0 16.7 1.5 8.4 16.7 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal GREB1 PF15782.5 ETO11272.1 - 0.94 6.5 7.6 1.3 6.1 7.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 ETO11272.1 - 1 7.6 17.3 1.5 7.0 17.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO11272.1 - 1.8 7.3 8.4 2.5 6.8 8.4 1.3 1 0 0 1 1 1 0 Presenilin U79_P34 PF03064.16 ETO11272.1 - 2.5 7.4 19.3 5 6.4 19.3 1.4 1 0 0 1 1 1 0 HSV U79 / HCMV P34 RR_TM4-6 PF06459.12 ETO11272.1 - 3.3 7.4 15.5 6.4 6.5 15.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF5308 PF17233.2 ETO11272.1 - 5.4 7.2 8.3 12 6.1 8.3 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5308) RPN2_C PF18004.1 ETO11272.1 - 6.6 6.6 20.6 17 5.3 20.6 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain PPL5 PF18168.1 ETO11272.1 - 9 5.5 10.4 16 4.7 10.4 1.4 1 0 0 1 1 1 0 Prim-pol family 5 CZB PF13682.6 ETO11273.1 - 0.052 14.0 0.1 8.7 6.9 0.0 2.4 2 0 0 2 2 2 0 Chemoreceptor zinc-binding domain MAGUK_N_PEST PF10608.9 ETO11273.1 - 0.11 13.0 0.1 0.14 12.6 0.1 1.2 1 0 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK UCH PF00443.29 ETO11274.1 - 1.9e-16 60.4 2.8 2.5e-16 59.9 2.8 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO11274.1 - 8.9e-06 25.5 5.6 9.4e-06 25.4 5.1 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PUB PF09409.10 ETO11276.1 - 2.2e-05 24.3 2.1 0.00017 21.5 0.3 2.8 1 1 1 2 2 2 1 PUB domain HEPN_RES_NTD1 PF18870.1 ETO11276.1 - 0.056 13.6 0.3 0.056 13.6 0.3 2.6 2 1 1 3 3 3 0 HEPN/RES N-terminal domain 1 PCI PF01399.27 ETO11276.1 - 5 7.7 8.4 3.5 8.2 5.5 2.2 1 1 1 2 2 2 0 PCI domain ART PF01129.18 ETO11277.1 - 0.00014 21.2 0.0 0.00026 20.3 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase LRR_8 PF13855.6 ETO11278.1 - 1.5e-30 104.7 40.7 1.3e-06 28.1 0.8 6.1 3 3 1 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ETO11278.1 - 4.1e-25 87.4 38.8 5e-06 26.8 1.0 7.5 3 2 2 7 7 7 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO11278.1 - 4.3e-16 57.0 41.9 0.25 12.0 0.1 12.8 11 2 2 13 13 13 7 Leucine Rich Repeat LRR_6 PF13516.6 ETO11278.1 - 5.3e-05 22.9 47.1 0.43 10.8 0.3 12.3 13 0 0 13 13 13 5 Leucine Rich repeat LRR_4 PF12799.7 ETO11279.1 - 0.00031 21.1 8.0 0.012 16.0 1.6 2.6 1 1 2 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO11279.1 - 0.14 11.9 11.7 0.55 10.0 6.1 2.6 1 1 0 2 2 2 0 Leucine rich repeat LRR_1 PF00560.33 ETO11279.1 - 0.61 10.8 6.5 79 4.4 1.3 4.0 3 1 0 3 3 3 0 Leucine Rich Repeat FAD_binding_8 PF08022.12 ETO11280.1 - 7.3e-14 51.8 0.0 1.1e-13 51.2 0.0 1.3 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ETO11280.1 - 0.00054 20.1 6.5 0.00054 20.1 6.5 1.9 2 0 0 2 2 2 1 Ferric reductase like transmembrane component FKBP_C PF00254.28 ETO11283.1 - 0.0002 21.6 0.0 0.00076 19.8 0.0 2.0 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase WH1 PF00568.23 ETO11283.1 - 0.00023 21.1 0.0 0.00052 19.9 0.0 1.5 1 0 0 1 1 1 1 WH1 domain UBX PF00789.20 ETO11284.1 - 6.6e-07 29.4 0.0 1.3e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 UBX domain Josephin PF02099.17 ETO11284.1 - 9.2e-07 29.1 0.2 9.2e-07 29.1 0.2 2.8 2 2 0 2 2 2 1 Josephin UIM PF02809.20 ETO11284.1 - 0.0068 16.2 16.3 1.3 9.1 1.1 3.3 3 0 0 3 3 3 3 Ubiquitin interaction motif tRNA-synt_His PF13393.6 ETO11285.1 - 1.8e-08 34.1 0.0 3.6e-08 33.0 0.0 1.6 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon2 PF12745.7 ETO11285.1 - 0.00049 19.7 0.1 0.0012 18.4 0.1 1.6 1 0 0 1 1 1 1 Anticodon binding domain of tRNAs FAT PF02259.23 ETO11286.1 - 1.6e-06 27.6 0.8 2.6e-06 26.9 0.8 1.3 1 0 0 1 1 1 1 FAT domain DUF4972 PF16342.5 ETO11288.1 - 0.005 16.5 1.1 0.0083 15.8 1.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4972) Orf78 PF06024.12 ETO11288.1 - 0.99 9.7 3.9 3.3 8.1 3.9 1.9 1 1 0 1 1 1 0 Orf78 (ac78) Shisa PF13908.6 ETO11288.1 - 9 6.5 17.8 0.16 12.2 8.2 2.7 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator zf-C3HC PF07967.13 ETO11290.1 - 0.0022 18.1 0.9 0.0022 18.1 0.9 3.1 4 0 0 4 4 4 1 C3HC zinc finger-like Pkinase PF00069.25 ETO11291.1 - 5.3e-13 48.9 0.1 6.7e-13 48.6 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11291.1 - 0.00085 18.7 0.0 0.001 18.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO11291.1 - 0.035 12.9 0.0 0.035 12.9 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase DUF1979 PF09322.10 ETO11291.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1979) AAA_28 PF13521.6 ETO11291.1 - 0.13 12.5 0.0 0.15 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 ETO11292.1 - 8.7e-18 64.6 0.0 9.8e-18 64.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11292.1 - 0.00082 18.7 0.1 0.0012 18.1 0.1 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Y_Y_Y PF07495.13 ETO11292.1 - 0.15 12.0 0.0 0.34 10.9 0.0 1.6 1 0 0 1 1 1 0 Y_Y_Y domain Fis1_TPR_C PF14853.6 ETO11292.1 - 0.17 11.9 0.0 0.31 11.1 0.0 1.4 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat adh_short PF00106.25 ETO11293.1 - 5.2e-34 117.4 0.1 7.9e-20 71.1 0.0 2.0 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO11293.1 - 2.7e-24 86.0 0.0 4.3e-17 62.5 0.0 2.0 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO11293.1 - 1.2e-05 25.3 0.0 2e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 KR domain Chordopox_A13L PF05961.11 ETO11293.1 - 0.023 14.9 0.2 2.7 8.3 0.1 2.6 2 0 0 2 2 2 0 Chordopoxvirus A13L protein NmrA PF05368.13 ETO11293.1 - 0.11 12.1 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 NmrA-like family TPR_2 PF07719.17 ETO11294.1 - 1e-22 78.3 5.9 0.00028 20.8 0.3 6.7 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11294.1 - 4.8e-22 77.4 1.2 1.5e-09 37.4 0.0 5.8 5 1 1 6 6 6 5 TPR repeat TPR_8 PF13181.6 ETO11294.1 - 3.2e-20 70.6 13.0 0.00025 21.0 0.1 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11294.1 - 1e-19 69.4 16.9 8.1e-05 22.3 0.8 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11294.1 - 2.4e-16 59.8 6.6 0.0074 16.6 0.2 6.0 4 2 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11294.1 - 4.7e-14 51.9 0.0 0.0022 18.7 0.0 5.9 2 2 4 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO11294.1 - 4.1e-11 43.3 0.0 0.19 12.4 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO11294.1 - 6.5e-08 33.0 0.1 0.018 15.5 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11294.1 - 7.7e-08 31.8 6.3 0.62 10.2 0.0 6.2 7 0 0 7 7 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO11294.1 - 1e-07 32.0 13.5 8.6e-06 25.9 1.7 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ETO11294.1 - 2.2e-07 31.1 2.4 9.4 7.1 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11294.1 - 1.4e-06 28.2 11.8 0.00013 22.1 0.2 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO11294.1 - 1.9e-06 27.9 0.0 0.73 10.0 0.0 3.6 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11294.1 - 0.00035 20.3 2.7 15 5.6 0.0 5.5 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO11294.1 - 0.00046 19.7 0.2 0.23 10.8 0.0 2.3 2 0 0 2 2 2 2 MalT-like TPR region TPR_15 PF13429.6 ETO11294.1 - 0.00079 18.7 1.1 0.22 10.7 1.1 3.5 1 1 0 1 1 1 1 Tetratricopeptide repeat SNAP PF14938.6 ETO11294.1 - 0.0025 17.3 0.3 0.0025 17.3 0.3 2.3 2 1 0 3 3 3 1 Soluble NSF attachment protein, SNAP DUF627 PF04781.12 ETO11294.1 - 0.0044 17.0 2.2 1.8 8.6 0.1 3.9 2 1 2 4 4 4 1 Protein of unknown function (DUF627) Exonuc_VII_S PF02609.16 ETO11294.1 - 0.56 10.3 4.2 58 3.9 0.1 4.2 4 0 0 4 4 4 0 Exonuclease VII small subunit MIT PF04212.18 ETO11294.1 - 1.4 9.0 7.7 1.4 9.0 0.1 4.0 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain ADK PF00406.22 ETO11296.1 - 4.9e-83 276.7 0.0 7.8e-49 165.6 0.0 2.1 2 0 0 2 2 2 2 Adenylate kinase ADK_lid PF05191.14 ETO11296.1 - 2e-33 114.0 0.3 9.2e-16 57.5 0.1 2.6 2 0 0 2 2 2 2 Adenylate kinase, active site lid AAA_17 PF13207.6 ETO11296.1 - 3.4e-28 98.8 0.0 1.4e-19 70.9 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_18 PF13238.6 ETO11296.1 - 0.0096 16.5 0.0 0.029 14.9 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO11296.1 - 0.029 14.5 0.0 0.23 11.6 0.0 2.2 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 ETO11296.1 - 0.061 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase NMO PF03060.15 ETO11297.1 - 1.6e-28 100.1 0.9 6.2e-25 88.3 0.1 2.0 2 0 0 2 2 2 2 Nitronate monooxygenase IMPDH PF00478.25 ETO11297.1 - 5.6e-06 25.6 0.0 1.5e-05 24.2 0.0 1.7 2 0 0 2 2 2 1 IMP dehydrogenase / GMP reductase domain NanE PF04131.14 ETO11297.1 - 0.014 14.6 0.0 0.024 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase APO_RNA-bind PF05634.11 ETO11297.1 - 0.068 12.5 0.5 0.11 11.8 0.5 1.3 1 0 0 1 1 1 0 APO RNA-binding NMO PF03060.15 ETO11298.1 - 8.3e-11 41.9 0.0 9.5e-11 41.7 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase DUF1902 PF08972.11 ETO11298.1 - 0.074 13.1 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) IQ PF00612.27 ETO11300.1 - 6e-06 25.6 0.0 1.3e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 IQ calmodulin-binding motif CSRNP_N PF16019.5 ETO11302.1 - 0.00087 19.3 21.7 0.066 13.1 11.1 2.8 2 1 1 3 3 3 2 Cysteine/serine-rich nuclear protein N-terminus SAP PF02037.27 ETO11302.1 - 0.018 14.8 0.0 0.75 9.6 0.0 2.6 2 0 0 2 2 2 0 SAP domain UAA PF08449.11 ETO11303.1 - 9.7e-10 38.1 7.3 1.8e-09 37.2 7.3 1.4 1 1 0 1 1 1 1 UAA transporter family Baculo_11_kDa PF06143.11 ETO11303.1 - 0.00062 19.3 2.4 0.0013 18.2 2.4 1.6 1 0 0 1 1 1 1 Baculovirus 11 kDa family DUF5385 PF17359.2 ETO11303.1 - 0.00092 18.8 1.9 0.0013 18.3 1.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5385) MFS_2 PF13347.6 ETO11303.1 - 0.013 14.0 2.8 0.023 13.3 2.5 1.6 1 1 1 2 2 2 0 MFS/sugar transport protein DUF929 PF06053.11 ETO11303.1 - 0.014 14.7 2.3 0.021 14.1 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF929) TMEM154 PF15102.6 ETO11303.1 - 0.029 14.3 0.8 0.06 13.3 0.8 1.5 1 0 0 1 1 1 0 TMEM154 protein family EphA2_TM PF14575.6 ETO11303.1 - 0.03 15.2 0.1 0.03 15.2 0.1 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain RSN1_TM PF13967.6 ETO11303.1 - 0.036 13.8 2.8 0.074 12.8 2.8 1.5 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Chordopox_A13L PF05961.11 ETO11303.1 - 0.045 14.0 3.8 0.12 12.7 3.8 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Sigma_reg_N PF13800.6 ETO11303.1 - 0.047 14.0 5.9 0.047 14.0 5.9 1.9 2 0 0 2 2 1 0 Sigma factor regulator N-terminal tRNA_anti-like PF12869.7 ETO11303.1 - 0.063 12.9 0.3 0.11 12.1 0.3 1.4 1 0 0 1 1 1 0 tRNA_anti-like DUF2615 PF11027.8 ETO11303.1 - 0.094 12.9 2.2 0.1 12.8 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) COX2_TM PF02790.15 ETO11303.1 - 0.16 12.2 6.4 0.2 11.8 2.2 2.4 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain ASFV_J13L PF05568.11 ETO11303.1 - 0.22 11.3 2.4 0.41 10.4 2.4 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein Glycophorin_A PF01102.18 ETO11303.1 - 0.27 11.5 3.6 0.27 11.5 0.3 2.5 2 1 1 3 3 3 0 Glycophorin A OppC_N PF12911.7 ETO11303.1 - 0.52 10.3 6.4 0.57 10.2 2.5 2.7 3 0 0 3 3 3 0 N-terminal TM domain of oligopeptide transport permease C EamA PF00892.20 ETO11303.1 - 0.69 10.1 18.0 2.5 8.3 0.3 2.9 2 1 0 2 2 2 0 EamA-like transporter family DUF443 PF04276.12 ETO11303.1 - 0.98 9.2 15.5 0.51 10.1 12.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF443) ATP-synt_8 PF00895.20 ETO11303.1 - 9.9 6.7 11.3 0.46 11.0 3.0 2.8 3 0 0 3 3 3 0 ATP synthase protein 8 RabGAP-TBC PF00566.18 ETO11304.1 - 0.23 11.1 4.6 0.11 12.2 1.6 1.8 1 1 1 2 2 2 0 Rab-GTPase-TBC domain RabGAP-TBC PF00566.18 ETO11305.1 - 8.9e-21 74.5 0.8 9.9e-21 74.4 0.8 1.0 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Rhodanese PF00581.20 ETO11306.1 - 0.00015 22.2 0.0 0.00035 21.1 0.0 1.6 1 0 0 1 1 1 1 Rhodanese-like domain Tubulin PF00091.25 ETO11308.1 - 1.7e-19 70.8 0.0 2.3e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain DUF2070 PF09843.9 ETO11308.1 - 0.19 10.0 4.7 0.29 9.4 4.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) HABP4_PAI-RBP1 PF04774.15 ETO11310.1 - 0.0049 17.7 1.8 0.0076 17.1 1.8 1.3 1 0 0 1 1 1 1 Hyaluronan / mRNA binding family DUF3464 PF11947.8 ETO11310.1 - 0.24 11.1 1.0 0.35 10.6 1.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 AAA_7 PF12775.7 ETO11311.1 - 5.1e-08 32.6 0.0 0.00029 20.4 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 ETO11311.1 - 8.2e-08 32.8 0.0 0.00015 22.2 0.0 2.8 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO11311.1 - 1.6e-07 31.7 0.0 0.0012 19.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ETO11311.1 - 6.5e-07 29.4 0.1 0.00058 19.9 0.0 3.3 4 1 0 4 4 4 1 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 ETO11311.1 - 3.4e-06 26.6 0.0 6.1e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 RsgA_GTPase PF03193.16 ETO11311.1 - 6.6e-06 26.1 0.4 1.3e-05 25.1 0.4 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_16 PF13191.6 ETO11311.1 - 5.8e-05 23.5 0.0 0.0013 19.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 ETO11311.1 - 0.00012 22.6 0.0 0.00065 20.2 0.0 2.2 3 0 0 3 3 2 1 ABC transporter MCM PF00493.23 ETO11311.1 - 0.00021 20.4 0.2 0.089 11.9 0.0 2.3 2 0 0 2 2 2 2 MCM P-loop domain AAA_14 PF13173.6 ETO11311.1 - 0.00052 20.1 0.0 0.0015 18.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 ETO11311.1 - 0.0011 18.7 0.0 0.013 15.2 0.0 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation DUF815 PF05673.13 ETO11311.1 - 0.0013 18.0 0.0 0.0033 16.6 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) Rad17 PF03215.15 ETO11311.1 - 0.0021 18.0 0.4 0.038 13.9 0.1 2.6 2 1 0 2 2 2 1 Rad17 P-loop domain RNA_helicase PF00910.22 ETO11311.1 - 0.0097 16.3 0.1 1.1 9.7 0.0 3.6 4 0 0 4 4 4 1 RNA helicase TsaE PF02367.17 ETO11311.1 - 0.011 15.7 0.1 0.059 13.4 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 ETO11311.1 - 0.014 15.5 0.0 0.67 10.1 0.0 3.1 3 0 0 3 3 3 0 Sigma-54 interaction domain AAA_24 PF13479.6 ETO11311.1 - 0.015 15.1 0.1 0.04 13.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETO11311.1 - 0.015 15.7 0.3 1.4 9.2 0.1 2.8 2 1 0 2 2 2 0 AAA domain Sigma54_activat PF00158.26 ETO11311.1 - 0.022 14.4 0.0 0.79 9.4 0.0 2.9 3 0 0 3 3 3 0 Sigma-54 interaction domain Roc PF08477.13 ETO11311.1 - 0.027 14.7 0.2 1 9.6 0.0 3.0 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ATPase_2 PF01637.18 ETO11311.1 - 0.043 13.7 0.0 0.085 12.8 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 ETO11311.1 - 0.045 13.5 0.0 0.087 12.5 0.0 1.5 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_2 PF07724.14 ETO11311.1 - 0.049 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) NACHT PF05729.12 ETO11311.1 - 0.06 13.3 0.1 0.32 10.9 0.1 2.1 2 0 0 2 2 2 0 NACHT domain IstB_IS21 PF01695.17 ETO11311.1 - 0.076 12.7 0.0 0.78 9.5 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO11311.1 - 0.078 12.4 0.0 2.6 7.4 0.0 2.3 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_30 PF13604.6 ETO11311.1 - 0.099 12.4 0.0 17 5.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETO11311.1 - 1.2 9.6 6.0 0.39 11.2 0.3 2.6 2 1 0 3 3 3 0 AAA domain dNK PF01712.19 ETO11311.1 - 2.3 8.0 5.3 2.4 8.0 0.5 3.3 3 1 0 3 3 3 0 Deoxynucleoside kinase DUF5644 PF18712.1 ETO11312.1 - 0.12 12.3 4.5 0.28 11.2 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5644) DUF948 PF06103.11 ETO11314.1 - 0.15 12.3 5.8 0.093 13.0 2.5 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) NTP_transf_2 PF01909.23 ETO11315.1 - 0.028 14.7 0.1 0.06 13.6 0.1 1.6 1 1 1 2 2 2 0 Nucleotidyltransferase domain SMODS PF18144.1 ETO11315.1 - 0.057 13.6 0.0 0.078 13.1 0.0 1.2 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain PC4 PF02229.16 ETO11315.1 - 0.85 9.3 2.7 1.6 8.4 0.7 2.0 2 0 0 2 2 2 0 Transcriptional Coactivator p15 (PC4) tRNA_bind PF01588.20 ETO11316.1 - 5.3e-25 87.4 0.0 6.8e-25 87.0 0.0 1.1 1 0 0 1 1 1 1 Putative tRNA binding domain Roc PF08477.13 ETO11317.1 - 0.076 13.2 0.0 0.21 11.8 0.0 1.8 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase SR-25 PF10500.9 ETO11319.1 - 0.05 13.2 19.2 0.068 12.8 19.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Smg8_Smg9 PF10220.9 ETO11319.1 - 0.096 11.0 6.3 0.11 10.8 6.3 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Presenilin PF01080.17 ETO11319.1 - 8.6 5.0 10.9 10 4.8 10.9 1.1 1 0 0 1 1 1 0 Presenilin DCB PF16213.5 ETO11320.1 - 1.9e-16 60.3 4.6 4.1e-16 59.2 4.6 1.6 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 TPR_1 PF00515.28 ETO11320.1 - 1.1e-09 37.6 3.1 2.4e-05 23.9 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11320.1 - 1.2e-09 37.5 3.0 0.00041 20.2 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11320.1 - 0.00017 21.2 0.1 0.00033 20.3 0.1 1.5 1 0 0 1 1 1 1 TPR repeat TPR_8 PF13181.6 ETO11320.1 - 0.036 14.3 0.1 4.5 7.7 0.0 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO11320.1 - 0.073 12.4 0.2 0.12 11.8 0.2 1.2 1 0 0 1 1 1 0 MalT-like TPR region TPR_17 PF13431.6 ETO11320.1 - 0.24 11.9 1.2 0.75 10.3 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Sec7 PF01369.20 ETO11321.1 - 6.7e-63 211.7 1.6 7.4e-63 211.5 0.3 1.7 2 0 0 2 2 2 1 Sec7 domain Sec7_N PF12783.7 ETO11321.1 - 1.5e-25 89.9 8.2 1.5e-25 89.9 8.2 2.2 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3641 PF12345.8 ETO11321.1 - 0.0095 16.0 0.5 0.059 13.4 0.0 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3641) Peptidase_U4 PF03419.13 ETO11322.1 - 0.0039 16.5 4.7 0.0044 16.4 4.7 1.1 1 0 0 1 1 1 1 Sporulation factor SpoIIGA DUF1981 PF09324.10 ETO11323.1 - 1.8e-11 43.8 0.8 1.1e-08 34.8 0.0 2.9 2 0 0 2 2 2 2 Domain of unknown function (DUF1981) Importin_rep_5 PF18816.1 ETO11323.1 - 0.0067 16.7 0.0 0.015 15.6 0.0 1.6 1 0 0 1 1 1 1 Importin repeat DUF4459 PF14673.6 ETO11324.1 - 0.02 14.8 0.0 0.026 14.5 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4459) Kelch_6 PF13964.6 ETO11324.1 - 0.075 13.3 0.5 3 8.3 0.1 2.7 2 1 1 3 3 3 0 Kelch motif ubiquitin PF00240.23 ETO11325.1 - 0.0014 18.3 0.0 0.0028 17.3 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO11325.1 - 0.024 14.5 0.1 0.048 13.5 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Flagellin_IN PF07196.13 ETO11325.1 - 0.066 13.4 0.1 0.12 12.6 0.1 1.4 1 0 0 1 1 1 0 Flagellin hook IN motif DinB PF05163.12 ETO11326.1 - 5.8e-05 23.1 0.6 0.00019 21.4 0.4 1.9 1 1 1 2 2 2 1 DinB family WD40 PF00400.32 ETO11327.1 - 1.6e-20 73.0 18.3 2.1e-07 31.5 1.1 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO11327.1 - 4.4e-08 32.2 1.6 0.0078 14.9 0.2 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11327.1 - 1.6e-06 28.3 0.0 0.0091 16.3 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain HELP PF03451.14 ETO11329.1 - 5.5e-05 22.9 0.2 8.8e-05 22.3 0.2 1.3 1 0 0 1 1 1 1 HELP motif DUF3835 PF12927.7 ETO11329.1 - 0.032 15.1 0.1 0.041 14.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3835) PEMT PF04191.13 ETO11330.1 - 0.088 13.2 0.2 0.13 12.7 0.2 1.3 1 0 0 1 1 1 0 Phospholipid methyltransferase TMEM223 PF14640.6 ETO11332.1 - 0.0062 16.7 0.6 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 Transmembrane protein 223 Flp_C PF05202.12 ETO11332.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 Recombinase Flp protein F-box-like PF12937.7 ETO11332.1 - 0.032 14.1 0.0 0.072 13.0 0.0 1.6 1 0 0 1 1 1 0 F-box-like DUF3899 PF13038.6 ETO11332.1 - 0.048 14.2 3.8 0.057 13.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) CHD5 PF04420.14 ETO11332.1 - 0.28 11.0 3.4 0.51 10.2 0.4 2.3 2 0 0 2 2 2 0 CHD5-like protein DSPc PF00782.20 ETO11333.1 - 3.9e-18 65.5 0.7 9.6e-18 64.3 0.1 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO11333.1 - 0.012 15.2 0.0 0.012 15.2 0.0 1.8 2 0 0 2 2 2 0 Protein-tyrosine phosphatase zf-CCHC_5 PF14787.6 ETO11333.1 - 0.14 11.8 0.1 0.28 10.9 0.1 1.4 1 0 0 1 1 1 0 GAG-polyprotein viral zinc-finger FeoB_associated PF12669.7 ETO11334.1 - 0.5 10.8 1.8 0.66 10.4 0.1 1.9 1 1 1 2 2 2 0 FeoB-associated Cys-rich membrane protein IER PF05760.12 ETO11335.1 - 0.031 14.6 0.4 0.064 13.6 0.4 1.6 1 0 0 1 1 1 0 Immediate early response protein (IER) Saf_2TM PF18303.1 ETO11335.1 - 0.092 12.3 0.0 0.19 11.3 0.0 1.5 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain ADK_lid PF05191.14 ETO11335.1 - 0.14 12.1 0.4 0.29 11.1 0.4 1.5 1 0 0 1 1 1 0 Adenylate kinase, active site lid Kelch_6 PF13964.6 ETO11336.1 - 7.9e-08 32.3 1.4 6.1e-05 23.2 0.1 3.9 3 1 1 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO11336.1 - 0.00071 19.8 0.1 0.36 11.2 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO11336.1 - 0.0011 18.9 0.1 0.014 15.4 0.0 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO11336.1 - 0.0031 17.1 1.5 0.51 10.0 0.1 3.8 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO11336.1 - 0.0031 17.4 1.7 0.088 12.8 0.4 3.0 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO11336.1 - 0.0097 15.9 2.0 0.3 11.1 0.1 3.2 3 0 0 3 3 3 1 Kelch motif WD40 PF00400.32 ETO11337.1 - 3.4e-67 220.7 12.4 6.6e-11 42.6 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11337.1 - 1.8e-22 79.4 2.1 0.00013 22.1 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11337.1 - 1.9e-20 73.1 0.6 0.00059 18.9 0.0 6.4 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO11337.1 - 3.5e-12 45.9 3.5 0.017 15.0 0.1 6.2 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO11337.1 - 3.9e-10 39.9 0.2 0.00018 21.4 0.1 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO11337.1 - 8.7e-09 34.4 0.3 0.00039 19.1 0.1 2.4 2 1 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO11337.1 - 2.2e-07 30.5 0.2 0.0018 17.7 0.1 3.5 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO11337.1 - 1.6e-05 23.8 7.3 0.1 11.2 0.0 4.0 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Frtz PF11768.8 ETO11337.1 - 6.5e-05 21.4 0.6 0.77 8.0 0.0 3.0 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETO11337.1 - 0.00072 18.4 4.9 1 8.0 0.1 4.2 1 1 3 4 4 4 2 Nup133 N terminal like DUF1258 PF06869.12 ETO11337.1 - 0.03 13.8 0.3 5.1 6.5 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1258) DUF727 PF05303.12 ETO11337.1 - 0.086 12.9 0.3 10 6.2 0.0 3.8 2 2 3 5 5 5 0 Protein of unknown function (DUF727) GATase PF00117.28 ETO11337.1 - 0.093 12.5 0.0 0.32 10.8 0.0 1.9 3 0 0 3 3 3 0 Glutamine amidotransferase class-I POLO_box PF00659.18 ETO11337.1 - 0.12 12.5 0.1 1.8 8.8 0.0 3.0 3 1 0 3 3 3 0 POLO box duplicated region DUF4999 PF16390.5 ETO11337.1 - 0.13 12.5 0.6 47 4.3 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO11337.1 - 1.9 8.2 5.4 60 3.5 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature RGS-like PF09128.11 ETO11338.1 - 0.017 14.8 0.3 0.021 14.6 0.3 1.1 1 0 0 1 1 1 0 Regulator of G protein signalling-like domain V-set_2 PF15910.5 ETO11339.1 - 0.0059 16.7 1.6 0.011 15.8 0.2 2.1 2 1 0 2 2 2 1 ICOS V-set domain PUD1_2 PF18457.1 ETO11340.1 - 4.2e-13 49.7 0.1 1.4e-10 41.5 0.6 2.4 1 1 1 2 2 2 2 Up-Regulated in long-lived daf-2 DZR PF12773.7 ETO11340.1 - 0.069 13.2 0.4 0.2 11.7 0.4 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 ETO11340.1 - 0.48 9.9 3.6 1.5 8.3 0.2 2.5 2 0 0 2 2 2 0 zinc-ribbon domain WD40 PF00400.32 ETO11341.1 - 1.1e-69 228.6 20.7 5.5e-11 42.8 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11341.1 - 1.1e-27 96.2 2.4 0.00082 19.6 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11341.1 - 5.4e-16 58.5 0.6 0.055 12.4 0.0 6.1 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11341.1 - 1e-10 41.4 2.1 0.0062 15.9 0.0 4.6 2 1 4 6 6 6 4 WD40-like domain Nup160 PF11715.8 ETO11341.1 - 5.1e-10 38.6 0.4 0.39 9.3 0.0 5.8 1 1 4 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO11341.1 - 9.1e-06 25.5 4.4 0.86 9.6 0.0 6.1 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Ricin_B_lectin PF00652.22 ETO11341.1 - 0.00047 20.4 0.5 0.37 11.0 0.3 3.3 2 2 1 3 3 3 1 Ricin-type beta-trefoil lectin domain Cytochrom_D1 PF02239.16 ETO11341.1 - 0.00098 17.7 0.3 1.3 7.5 0.0 3.1 1 1 3 4 4 4 3 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO11341.1 - 0.0012 17.7 1.5 0.48 9.1 0.1 4.6 2 1 2 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO11341.1 - 0.0031 17.4 0.0 9.9 6.3 0.0 4.8 6 0 0 6 6 5 1 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETO11341.1 - 0.01 15.5 1.9 7.6 6.3 0.1 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature ROS_MUCR PF05443.11 ETO11341.1 - 0.017 15.2 0.2 5.3 7.1 0.0 3.1 2 2 0 2 2 2 0 ROS/MUCR transcriptional regulator protein nos_propeller PF18764.1 ETO11341.1 - 0.03 14.2 0.0 15 5.6 0.0 3.9 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat Str_synth PF03088.16 ETO11341.1 - 0.043 13.9 0.0 18 5.5 0.0 3.7 3 1 1 4 4 3 0 Strictosidine synthase DUF2963 PF11178.8 ETO11341.1 - 0.062 13.0 1.7 1.4 8.7 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2963) VID27 PF08553.10 ETO11341.1 - 0.074 12.1 0.0 3.3 6.7 0.0 2.4 1 1 1 3 3 3 0 VID27 C-terminal WD40-like domain DUF5449 PF17528.2 ETO11341.1 - 0.12 12.2 0.2 0.68 9.7 0.0 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5449) Snapin_Pallidin PF14712.6 ETO11342.1 - 0.004 17.5 2.4 0.004 17.5 2.4 8.7 4 3 5 9 9 9 1 Snapin/Pallidin DUF3618 PF12277.8 ETO11342.1 - 2.3 8.5 10.8 23 5.4 0.2 5.5 6 0 0 6 6 6 0 Protein of unknown function (DUF3618) WD40 PF00400.32 ETO11343.1 - 1.7e-29 101.4 14.6 9.2e-06 26.3 0.1 6.3 6 2 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO11343.1 - 7.2e-09 34.8 1.8 0.079 11.6 0.0 4.8 2 2 3 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11343.1 - 2.6e-07 30.8 0.4 1.8 8.9 0.0 5.0 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO11343.1 - 0.0044 17.0 1.6 0.4 10.7 0.1 3.6 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region ADIP PF11559.8 ETO11346.1 - 0.004 17.3 23.0 0.004 17.3 23.0 4.1 1 1 3 4 4 4 1 Afadin- and alpha -actinin-Binding COG2 PF06148.11 ETO11346.1 - 0.01 15.9 9.8 0.01 15.9 9.8 4.7 1 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 MscS_porin PF12795.7 ETO11346.1 - 0.41 10.2 85.5 11 5.5 37.0 2.8 1 1 2 3 3 3 0 Mechanosensitive ion channel porin domain Spc7 PF08317.11 ETO11346.1 - 3.8 6.3 91.7 3.3 6.5 36.9 3.5 1 1 2 3 3 3 0 Spc7 kinetochore protein HMMR_N PF15905.5 ETO11346.1 - 4.5 6.6 97.2 0.15 11.5 18.0 3.0 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DHR10 PF18595.1 ETO11346.1 - 9.1 6.4 104.1 0.041 13.9 15.0 5.5 1 1 4 5 5 5 0 Designed helical repeat protein 10 domain MDM1 PF15501.6 ETO11347.1 - 0.034 13.3 29.4 0.059 12.5 29.4 1.3 1 0 0 1 1 1 0 Nuclear protein MDM1 LAP1C PF05609.12 ETO11347.1 - 0.4 9.7 22.2 0.68 9.0 22.2 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CCD48 PF15799.5 ETO11348.1 - 0.015 13.6 1.5 0.02 13.2 1.5 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 CdiI_2 PF18593.1 ETO11350.1 - 0.053 14.2 0.1 0.099 13.3 0.1 1.5 1 0 0 1 1 1 0 CdiI immunity protein KIP1 PF07765.12 ETO11350.1 - 0.28 11.3 2.1 0.56 10.4 2.1 1.5 1 0 0 1 1 1 0 KIP1-like protein FtsX PF02687.21 ETO11352.1 - 4.3e-10 39.9 11.5 4.3e-10 39.9 11.5 2.9 3 0 0 3 3 3 1 FtsX-like permease family GED PF02212.18 ETO11354.1 - 0.051 13.7 1.2 0.073 13.2 0.4 1.6 1 1 1 2 2 2 0 Dynamin GTPase effector domain Histone PF00125.24 ETO11355.1 - 8.9e-19 68.2 0.5 1.3e-18 67.6 0.5 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ETO11355.1 - 7.3e-07 29.4 0.1 1.5e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ETO11355.1 - 0.14 12.6 0.5 0.56 10.7 0.1 1.9 1 1 1 2 2 2 0 Transcription initiation factor TFIID subunit A Actin PF00022.19 ETO11356.1 - 8.9e-86 288.0 0.0 3.3e-85 286.2 0.0 1.7 1 1 0 1 1 1 1 Actin Ras PF00071.22 ETO11359.1 - 1.6e-33 115.6 1.1 7.7e-24 84.1 0.1 2.8 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ETO11359.1 - 4.7e-11 43.0 0.1 3.9e-10 40.0 0.1 2.2 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GxGYxYP_C PF14323.6 ETO11359.1 - 0.023 14.6 0.0 0.037 13.9 0.0 1.3 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain PsaD PF02531.16 ETO11359.1 - 0.06 12.9 0.3 4 7.0 0.1 2.3 2 0 0 2 2 2 0 PsaD Peptidase_C1 PF00112.23 ETO11360.1 - 1.3e-54 185.5 5.4 1.3e-54 185.5 5.4 2.0 3 0 0 3 3 3 1 Papain family cysteine protease Inhibitor_I29 PF08246.12 ETO11360.1 - 5.3e-14 52.4 0.3 1.1e-13 51.4 0.3 1.6 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) Peptidase_C1_2 PF03051.15 ETO11360.1 - 0.00028 19.8 0.3 0.0006 18.7 0.3 1.5 1 0 0 1 1 1 1 Peptidase C1-like family Steroid_dh PF02544.16 ETO11361.1 - 2.5e-37 128.1 2.4 2.5e-37 128.1 2.4 1.5 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase zf-TRAF PF02176.18 ETO11362.1 - 7.7e-05 23.3 2.3 0.00033 21.3 1.9 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger Methyltransf_31 PF13847.6 ETO11362.1 - 0.025 14.4 0.0 0.079 12.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ETO11362.1 - 0.034 13.9 0.0 0.41 10.4 0.0 2.4 1 1 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 ETO11362.1 - 0.074 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_25 PF13649.6 ETO11362.1 - 0.16 12.7 0.0 0.59 10.9 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Sina PF03145.16 ETO11362.1 - 0.22 11.5 10.3 3.4 7.6 10.3 3.1 1 1 0 1 1 1 0 Seven in absentia protein family UPF0449 PF15136.6 ETO11362.1 - 1.7 9.2 7.5 0.62 10.6 3.1 2.7 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 DUF1492 PF07374.11 ETO11365.1 - 0.031 14.4 0.2 0.078 13.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1492) Glyco_hydro_35 PF01301.19 ETO11367.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 35 Epimerase PF01370.21 ETO11368.1 - 4.3e-21 75.5 0.0 1.2e-20 74.1 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO11368.1 - 3.7e-14 52.4 0.0 5.7e-14 51.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETO11368.1 - 1.3e-11 44.7 0.0 1.3e-10 41.5 0.0 2.2 1 1 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ETO11368.1 - 2.9e-08 33.5 0.0 5e-08 32.7 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ETO11368.1 - 3e-07 30.3 0.0 0.00042 19.9 0.0 2.2 2 0 0 2 2 2 2 NmrA-like family NAD_binding_4 PF07993.12 ETO11368.1 - 6.9e-07 28.7 0.0 1.6e-06 27.5 0.0 1.6 1 1 0 1 1 1 1 Male sterility protein KR PF08659.10 ETO11368.1 - 0.0047 16.9 0.0 0.0084 16.0 0.0 1.3 1 0 0 1 1 1 1 KR domain DHHC PF01529.20 ETO11369.1 - 7e-21 74.7 33.6 2.7e-18 66.4 20.8 4.4 4 1 0 4 4 4 2 DHHC palmitoyltransferase FYVE PF01363.21 ETO11369.1 - 7.3 6.8 14.1 1.3 9.2 8.6 2.5 2 1 0 2 2 2 0 FYVE zinc finger WD40 PF00400.32 ETO11371.1 - 8.6e-10 39.1 1.8 0.00058 20.6 0.1 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11371.1 - 0.0011 19.2 0.0 0.31 11.3 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_5 PF13854.6 ETO11372.1 - 0.089 12.8 1.8 1.5 8.9 0.1 3.3 4 0 0 4 4 4 0 Kelch motif ResIII PF04851.15 ETO11373.1 - 0.011 15.8 0.3 0.011 15.8 0.3 2.2 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit Stealth_CR2 PF11380.8 ETO11374.1 - 1.7e-45 153.7 0.2 4.3e-45 152.3 0.2 1.8 1 0 0 1 1 1 1 Stealth protein CR2, conserved region 2 Notch PF00066.17 ETO11374.1 - 1e-15 57.9 33.0 7e-09 36.0 15.3 2.3 2 0 0 2 2 2 2 LNR domain DUF760 PF05542.11 ETO11374.1 - 1.2 9.5 3.0 3 8.2 0.1 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF760) DUF4304 PF14137.6 ETO11374.1 - 3.1 8.0 5.6 23 5.2 0.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4304) Stealth_CR4 PF17103.5 ETO11375.1 - 5.1e-17 61.5 0.6 1.6e-16 59.9 0.6 1.9 1 0 0 1 1 1 1 Stealth protein CR4, conserved region 4 Stealth_CR3 PF17102.5 ETO11375.1 - 4.1e-15 55.4 5.1 1.1e-14 54.0 5.1 1.8 1 0 0 1 1 1 1 Stealth protein CR3, conserved region 3 DUF4713 PF15831.5 ETO11375.1 - 1.5 9.3 5.8 3.6 8.1 4.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) RRM_1 PF00076.22 ETO11376.1 - 1.1e-11 44.3 0.1 2.8e-11 43.0 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Presenilin PF01080.17 ETO11376.1 - 0.0044 15.9 4.9 0.0052 15.6 4.9 1.2 1 0 0 1 1 1 1 Presenilin Mem_trans PF03547.18 ETO11376.1 - 0.023 13.1 0.5 0.023 13.1 0.5 1.1 1 0 0 1 1 1 0 Membrane transport protein Menin PF05053.13 ETO11376.1 - 0.04 12.3 7.4 0.053 11.9 7.4 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO11376.1 - 0.14 11.4 2.4 0.15 11.3 2.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter GREB1 PF15782.5 ETO11376.1 - 0.15 9.2 15.1 0.19 8.8 15.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Ndc1_Nup PF09531.10 ETO11376.1 - 0.24 10.1 8.6 0.28 9.8 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup NPR3 PF03666.13 ETO11376.1 - 0.42 9.4 15.2 0.43 9.3 14.2 1.5 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DDHD PF02862.17 ETO11376.1 - 1 9.5 10.3 1.5 8.9 10.3 1.2 1 0 0 1 1 1 0 DDHD domain DUF936 PF06075.12 ETO11376.1 - 2.9 6.7 23.1 3.7 6.4 23.1 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) ALMT PF11744.8 ETO11376.1 - 4.7 5.9 12.6 6.7 5.4 12.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 ETO11376.1 - 5.3 5.2 12.8 7.4 4.7 12.8 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF908 PF06012.12 ETO11376.1 - 5.5 6.3 14.6 7.6 5.8 14.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) CLN3 PF02487.17 ETO11376.1 - 7.9 5.4 6.2 11 4.9 6.2 1.2 1 0 0 1 1 1 0 CLN3 protein Kei1 PF08552.11 ETO11376.1 - 8.7 6.2 5.6 13 5.6 5.6 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Ebp2 PF05890.12 ETO11377.1 - 5.8e-42 144.1 31.5 9.2e-42 143.4 31.4 1.4 1 1 0 1 1 1 1 Eukaryotic rRNA processing protein EBP2 EF-hand_1 PF00036.32 ETO11379.1 - 2.3e-12 45.5 7.2 0.00014 21.2 0.6 3.6 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ETO11379.1 - 3.8e-10 40.1 5.7 0.00022 21.6 3.7 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO11379.1 - 1.8e-09 36.8 2.1 0.00058 19.6 0.2 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_8 PF13833.6 ETO11379.1 - 2.9e-05 23.8 6.9 0.037 13.9 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO11379.1 - 0.00026 20.9 4.1 0.0032 17.4 0.0 2.9 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO11379.1 - 0.018 15.3 0.8 0.19 12.1 0.2 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO11379.1 - 1.9 8.1 8.6 0.65 9.6 1.1 3.2 3 0 0 3 3 3 0 EF hand Ldh_1_C PF02866.18 ETO11380.1 - 2.5e-32 112.1 0.0 1.4e-31 109.7 0.0 1.8 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ETO11380.1 - 3e-12 46.8 0.1 5e-12 46.1 0.1 1.4 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain CPSase_L_D3 PF02787.19 ETO11381.1 - 0.0086 16.4 0.4 0.012 15.9 0.4 1.3 1 0 0 1 1 1 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain zf-RanBP PF00641.18 ETO11382.1 - 1.5e-05 24.2 1.3 3.5e-05 23.0 1.3 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ETO11382.1 - 0.078 13.0 1.6 0.13 12.4 0.0 2.1 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 ETO11382.1 - 0.093 12.1 4.1 0.065 12.6 1.6 2.0 2 1 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Kelch_6 PF13964.6 ETO11383.1 - 3.3e-06 27.2 5.0 0.48 10.8 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO11383.1 - 3.5e-05 23.3 0.2 0.58 9.8 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO11383.1 - 9.8e-05 22.2 1.6 0.27 11.3 0.1 4.4 5 1 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO11383.1 - 0.0021 18.0 0.6 14 5.8 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO11383.1 - 0.074 13.1 0.0 1.8 8.7 0.0 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain AAA PF00004.29 ETO11384.1 - 2.7e-06 27.8 0.0 5.1e-06 26.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO11384.1 - 0.0004 20.2 0.0 0.00075 19.3 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 ETO11384.1 - 0.003 18.1 0.0 0.0073 16.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 ETO11384.1 - 0.0057 17.2 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETO11384.1 - 0.0058 16.4 0.0 0.029 14.1 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 ETO11384.1 - 0.0075 16.7 0.0 0.023 15.1 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain AAA_5 PF07728.14 ETO11384.1 - 0.0088 16.0 0.0 0.018 15.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ETO11384.1 - 0.015 15.7 0.0 0.044 14.2 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_29 PF13555.6 ETO11384.1 - 0.018 14.7 0.0 0.037 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO11384.1 - 0.022 15.0 1.4 0.44 10.8 0.1 2.7 2 1 1 3 3 3 0 AAA domain AAA_25 PF13481.6 ETO11384.1 - 0.04 13.5 0.0 0.066 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO11384.1 - 0.045 13.5 0.0 0.097 12.4 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain RsgA_GTPase PF03193.16 ETO11384.1 - 0.071 13.0 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase NTPase_1 PF03266.15 ETO11384.1 - 0.085 12.8 0.0 0.28 11.1 0.0 1.9 1 0 0 1 1 1 0 NTPase ATPase PF06745.13 ETO11384.1 - 0.12 11.8 0.1 0.3 10.4 0.0 1.7 2 0 0 2 2 2 0 KaiC AAA_23 PF13476.6 ETO11384.1 - 0.18 12.3 2.5 0.27 11.7 0.0 2.2 3 0 0 3 3 2 0 AAA domain Zeta_toxin PF06414.12 ETO11384.1 - 0.19 11.0 0.0 1.6 8.0 0.0 2.1 2 0 0 2 2 2 0 Zeta toxin RsbU_N PF08673.10 ETO11385.1 - 0.054 13.6 0.2 0.2 11.7 0.2 2.0 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain KinB_sensor PF16767.5 ETO11385.1 - 0.096 13.2 0.7 9.9 6.7 0.0 3.6 4 0 0 4 4 4 0 Sensor domain of alginate biosynthesis sensor protein KinB PBECR3 PF18812.1 ETO11385.1 - 0.24 11.3 3.0 0.22 11.5 0.2 2.4 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 IBR PF01485.21 ETO11385.1 - 0.51 10.6 2.9 1.6 9.0 1.1 2.5 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain AAA_22 PF13401.6 ETO11387.1 - 0.0046 17.2 0.1 0.029 14.6 0.0 2.4 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETO11387.1 - 0.018 14.6 0.0 0.044 13.3 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region CRAL_TRIO_2 PF13716.6 ETO11387.1 - 0.034 14.3 5.4 0.11 12.6 0.7 3.4 4 0 0 4 4 4 0 Divergent CRAL/TRIO domain AAA PF00004.29 ETO11387.1 - 0.045 14.2 0.3 0.21 12.0 0.0 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO11387.1 - 0.09 12.8 0.1 0.52 10.3 0.1 2.3 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ResIII PF04851.15 ETO11389.1 - 0.0025 17.8 0.1 0.0043 17.1 0.1 1.4 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit HA70_C PF17993.1 ETO11389.1 - 0.027 14.5 0.0 0.068 13.2 0.0 1.7 2 0 0 2 2 2 0 Haemagglutinin 70 C-terminal domain DUF3810 PF12725.7 ETO11389.1 - 0.035 13.5 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Kelch_1 PF01344.25 ETO11390.1 - 0.016 14.8 0.2 0.19 11.3 0.1 2.8 3 0 0 3 3 3 0 Kelch motif CodY PF06018.14 ETO11390.1 - 0.016 14.7 0.0 0.033 13.7 0.0 1.4 1 0 0 1 1 1 0 CodY GAF-like domain HMG_box_2 PF09011.10 ETO11390.1 - 0.46 11.1 0.1 0.46 11.1 0.1 2.1 2 0 0 2 2 2 0 HMG-box domain WD40 PF00400.32 ETO11391.1 - 2.7e-50 167.3 16.0 4.1e-10 40.1 0.1 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11391.1 - 2.8e-17 62.8 1.7 0.00014 22.0 0.2 5.2 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11391.1 - 6e-13 48.4 2.6 0.0077 15.2 0.0 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11391.1 - 7.6e-08 32.0 2.4 0.028 13.8 0.1 3.6 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO11391.1 - 2e-05 23.5 6.1 0.53 8.9 0.1 4.3 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO11391.1 - 0.00018 20.2 1.3 0.005 15.4 0.0 2.8 1 1 3 4 4 4 2 Cytochrome D1 heme domain Frtz PF11768.8 ETO11391.1 - 0.00097 17.6 0.2 0.014 13.8 0.0 2.2 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz HPS3_N PF14761.6 ETO11391.1 - 0.001 18.6 0.0 0.36 10.3 0.0 2.8 3 0 0 3 3 3 1 Hermansky-Pudlak syndrome 3 DPPIV_N PF00930.21 ETO11391.1 - 0.0068 15.2 0.1 0.093 11.5 0.1 2.5 1 1 2 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO11391.1 - 0.013 15.4 0.4 12 6.0 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat ArlS_N PF18719.1 ETO11391.1 - 0.018 15.3 0.2 2.1 8.6 0.1 2.8 1 1 1 2 2 2 0 ArlS sensor domain LBP_BPI_CETP_C PF02886.17 ETO11391.1 - 0.023 14.2 0.0 5.2 6.4 0.0 2.4 2 0 0 2 2 2 0 LBP / BPI / CETP family, C-terminal domain GATase PF00117.28 ETO11391.1 - 0.024 14.4 0.0 1.5 8.5 0.0 2.4 1 1 1 2 2 2 0 Glutamine amidotransferase class-I SBD PF17882.1 ETO11391.1 - 0.04 13.7 0.5 18 5.2 0.0 3.5 2 2 2 4 4 4 0 OAA-family lectin sugar binding domain Cadherin_4 PF17803.1 ETO11391.1 - 0.059 14.0 0.5 1.6 9.4 0.1 2.7 1 1 1 2 2 2 0 Bacterial cadherin-like domain POLO_box PF00659.18 ETO11391.1 - 0.063 13.5 1.4 0.71 10.1 0.1 2.7 2 1 1 3 3 2 0 POLO box duplicated region Methyltransf_3 PF01596.17 ETO11391.1 - 0.12 11.5 0.0 11 5.1 0.0 2.9 1 1 2 3 3 3 0 O-methyltransferase Proteasome_A_N PF10584.9 ETO11391.1 - 2.9 7.7 5.7 11 5.8 0.0 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Ras PF00071.22 ETO11392.1 - 1.1e-18 67.4 0.0 1.4e-18 67.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO11392.1 - 5.2e-08 33.1 0.1 1.6e-07 31.6 0.0 1.9 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO11392.1 - 0.00012 21.6 0.1 0.0002 20.9 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO11392.1 - 0.0007 19.0 0.1 0.00077 18.9 0.1 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DUF1765 PF08578.10 ETO11392.1 - 0.074 13.5 0.1 0.13 12.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1765) GTP_EFTU PF00009.27 ETO11392.1 - 0.094 12.2 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain RGS12_us1 PF16613.5 ETO11393.1 - 2.1 8.7 7.5 8.8 6.7 4.9 2.1 2 0 0 2 2 2 0 Unstructured region of RGS12 GLTSCR1 PF15249.6 ETO11393.1 - 3.4 8.2 11.3 0.59 10.6 2.3 2.2 1 1 1 2 2 2 0 Conserved region of unknown function on GLTSCR protein cpYpsA PF12694.7 ETO11394.1 - 5.5e-39 133.2 1.2 2.1e-38 131.4 0.0 2.3 1 1 1 2 2 2 1 Circularly permutated YpsA SLOG family TMIE PF16038.5 ETO11394.1 - 0.027 14.3 1.3 0.027 14.3 1.3 2.2 2 0 0 2 2 2 0 TMIE protein Tfb4 PF03850.14 ETO11394.1 - 0.33 10.4 2.8 0.33 10.4 0.5 2.1 2 0 0 2 2 2 0 Transcription factor Tfb4 SNF2_N PF00176.23 ETO11395.1 - 1.2e-43 149.2 4.4 1.4e-43 149.0 4.4 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO11395.1 - 2.9e-12 46.9 0.1 9.4e-12 45.3 0.0 1.7 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO11395.1 - 2e-07 31.0 0.0 3.6e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ETO11395.1 - 6.2e-05 22.8 0.4 0.00046 19.9 0.0 2.4 2 1 0 2 2 2 1 SWI2/SNF2 ATPase Spore_YunB PF09560.10 ETO11396.1 - 0.024 14.7 0.2 0.087 12.8 0.1 2.0 1 1 1 2 2 2 0 Sporulation protein YunB (Spo_YunB) ODV-E18 PF10717.9 ETO11396.1 - 0.033 14.1 0.2 0.053 13.4 0.2 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 PBP_sp32 PF07222.12 ETO11397.1 - 0.031 13.7 2.8 0.038 13.5 2.8 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PPP4R2 PF09184.11 ETO11397.1 - 4.8 6.7 20.5 5.1 6.6 20.5 1.0 1 0 0 1 1 1 0 PPP4R2 CAC1F_C PF16885.5 ETO11397.1 - 8.4 6.0 11.3 10 5.7 11.3 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term ORC2 PF04084.14 ETO11399.1 - 1.6e-43 148.9 0.2 2e-43 148.6 0.2 1.0 1 0 0 1 1 1 1 Origin recognition complex subunit 2 YbfN PF13982.6 ETO11399.1 - 0.092 13.0 0.0 0.17 12.2 0.0 1.4 1 0 0 1 1 1 0 YbfN-like lipoprotein Squash PF00299.18 ETO11400.1 - 0.19 11.8 0.1 0.4 10.7 0.1 1.5 1 0 0 1 1 1 0 Squash family serine protease inhibitor DUF2148 PF09918.9 ETO11400.1 - 0.2 11.7 0.0 0.32 11.0 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein containing a ferredoxin domain (DUF2148) ATG101 PF07855.12 ETO11401.1 - 2.8e-11 43.6 0.6 3.4e-11 43.4 0.6 1.1 1 0 0 1 1 1 1 Autophagy-related protein 101 Kelch_2 PF07646.15 ETO11402.1 - 1.3e-06 28.1 0.7 0.00041 20.2 0.2 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO11402.1 - 6.5e-05 22.9 1.5 0.048 13.7 0.2 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO11402.1 - 0.00029 21.0 1.7 0.36 11.2 0.3 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO11402.1 - 0.012 15.2 2.2 0.027 14.1 0.8 2.0 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO11402.1 - 0.018 15.3 0.3 0.26 11.6 0.0 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO11402.1 - 0.027 14.4 4.3 0.19 11.7 0.7 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO11404.1 - 2.9e-06 26.8 1.0 0.0017 17.9 0.1 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO11404.1 - 5.8e-05 22.9 3.3 0.02 14.9 0.1 4.5 4 1 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO11404.1 - 6.7e-05 23.0 2.6 0.11 12.8 0.2 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO11404.1 - 0.0039 17.2 0.2 0.079 13.0 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain tRNA-synt_1c_C PF03950.18 ETO11404.1 - 0.07 13.0 0.1 0.15 11.9 0.1 1.5 1 0 0 1 1 1 0 tRNA synthetases class I (E and Q), anti-codon binding domain Kelch_5 PF13854.6 ETO11404.1 - 0.48 10.5 6.4 0.61 10.1 0.7 3.6 4 0 0 4 4 4 0 Kelch motif LMF1 PF06762.14 ETO11405.1 - 4.7e-62 210.5 29.6 1.1e-37 130.2 10.6 2.4 1 1 1 2 2 2 2 Lipase maturation factor DUF3999 PF13163.6 ETO11405.1 - 0.12 11.5 0.2 0.21 10.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3999) Kelch_5 PF13854.6 ETO11406.1 - 2.2e-05 24.3 2.4 0.43 10.6 0.1 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO11406.1 - 0.0044 17.3 2.8 22 5.5 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO11406.1 - 0.17 12.2 6.3 30 5.0 1.4 4.1 4 0 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO11407.1 - 1.3e-67 222.0 21.6 3.2e-10 40.4 0.3 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11407.1 - 4.6e-27 94.2 5.1 5.3e-05 23.4 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11407.1 - 2.1e-15 56.6 0.2 0.019 13.9 0.0 5.9 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO11407.1 - 2.6e-15 56.8 0.1 0.00039 20.3 0.0 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO11407.1 - 7.9e-13 48.4 1.0 6.9e-05 22.3 0.1 4.3 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO11407.1 - 1.3e-11 43.9 4.7 0.01 14.5 0.0 5.2 2 2 2 5 5 5 5 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO11407.1 - 5e-07 28.6 2.9 0.031 12.8 0.1 3.2 1 1 3 4 4 4 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO11407.1 - 8e-06 26.0 5.1 22 5.2 0.0 5.9 1 1 4 6 6 6 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO11407.1 - 1e-05 25.3 2.5 3.9 7.5 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Ricin_B_lectin PF00652.22 ETO11407.1 - 0.00023 21.4 2.4 0.22 11.8 0.2 3.2 1 1 3 4 4 4 2 Ricin-type beta-trefoil lectin domain PQQ PF01011.21 ETO11407.1 - 0.0004 20.2 0.0 27 4.9 0.0 5.7 6 0 0 6 6 6 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO11407.1 - 0.00062 18.6 11.1 2.1 7.0 0.3 5.1 1 1 5 6 6 6 3 Nup133 N terminal like Nbas_N PF15492.6 ETO11407.1 - 0.0012 18.2 1.0 3.8 6.7 0.0 4.1 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal NHL PF01436.21 ETO11407.1 - 0.0022 17.9 0.8 10 6.4 0.4 3.6 3 0 0 3 3 3 0 NHL repeat nos_propeller PF18764.1 ETO11407.1 - 0.0071 16.2 0.2 13 5.8 0.0 4.7 4 2 1 5 5 5 0 Nitrous oxide reductase propeller repeat Phage_CI_repr PF07022.13 ETO11407.1 - 0.023 14.8 0.1 2.5 8.2 0.0 3.0 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain DUF1513 PF07433.11 ETO11407.1 - 0.042 12.9 0.3 13 4.7 0.0 3.6 2 2 2 4 4 4 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETO11407.1 - 0.13 11.9 4.7 30 4.4 0.3 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature HPS6 PF15702.5 ETO11407.1 - 0.18 9.7 0.0 22 2.9 0.0 3.2 1 1 2 4 4 4 0 Hermansky-Pudlak syndrome 6 protein SPX PF03105.19 ETO11408.1 - 1.8 8.4 17.6 2.3 8.1 17.6 1.2 1 0 0 1 1 1 0 SPX domain WD40 PF00400.32 ETO11409.1 - 5.4e-17 61.9 1.8 4.8e-05 24.0 0.0 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11409.1 - 0.0014 18.9 0.0 7.5 6.9 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11409.1 - 0.013 14.2 0.2 0.37 9.4 0.1 2.4 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Head-tail_con PF12236.8 ETO11411.1 - 0.039 12.4 0.0 0.045 12.2 0.0 1.0 1 0 0 1 1 1 0 Bacteriophage head to tail connecting protein ubiquitin PF00240.23 ETO11412.1 - 9e-19 67.0 1.5 1.4e-18 66.4 1.5 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO11412.1 - 3e-09 36.6 1.5 4.7e-09 35.9 1.5 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like UN_NPL4 PF11543.8 ETO11412.1 - 0.0012 19.3 1.6 0.0022 18.4 1.6 1.5 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 Ubiquitin_2 PF14560.6 ETO11412.1 - 0.008 16.6 0.5 0.029 14.8 0.5 1.8 1 1 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO11412.1 - 0.016 15.1 0.1 0.027 14.4 0.1 1.3 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain UBX PF00789.20 ETO11412.1 - 0.12 12.6 0.1 0.24 11.6 0.1 1.5 1 0 0 1 1 1 0 UBX domain Mut7-C PF01927.16 ETO11412.1 - 0.14 12.2 0.4 0.21 11.7 0.4 1.5 1 1 0 1 1 1 0 Mut7-C RNAse domain OpcA_G6PD_assem PF10128.9 ETO11412.1 - 0.29 10.6 0.3 0.39 10.2 0.3 1.2 1 0 0 1 1 1 0 Glucose-6-phosphate dehydrogenase subunit Ceramidase PF05875.12 ETO11413.1 - 0.00033 20.2 0.6 0.00035 20.1 0.6 1.1 1 0 0 1 1 1 1 Ceramidase MCM PF00493.23 ETO11414.1 - 4.6e-85 284.3 0.6 4.1e-74 248.5 0.2 2.2 2 0 0 2 2 2 2 MCM P-loop domain MCM_OB PF17207.3 ETO11414.1 - 5.6e-31 107.0 1.9 1.4e-30 105.8 1.9 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETO11414.1 - 1.1e-21 77.0 0.7 3.5e-21 75.4 0.7 1.9 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ETO11414.1 - 5.1e-05 22.8 1.3 0.0002 20.8 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_lid_2 PF17863.1 ETO11414.1 - 0.015 15.2 0.1 0.036 13.9 0.1 1.6 1 0 0 1 1 1 0 AAA lid domain Mg_chelatase_C PF13335.6 ETO11414.1 - 0.019 15.6 0.6 1.3 9.7 0.1 3.4 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI C-terminal AAA_3 PF07726.11 ETO11414.1 - 0.078 12.8 0.0 0.16 11.8 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RecX PF02631.16 ETO11414.1 - 0.094 13.2 0.1 0.25 11.8 0.1 1.7 1 0 0 1 1 1 0 RecX family Annexin PF00191.20 ETO11415.1 - 0.00011 22.1 1.4 0.00044 20.3 0.1 2.4 2 0 0 2 2 2 1 Annexin TPR_MLP1_2 PF07926.12 ETO11415.1 - 0.003 17.6 11.0 0.0061 16.6 11.0 1.5 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DNA_Packaging PF11053.8 ETO11415.1 - 0.0056 16.6 0.5 0.0096 15.8 0.5 1.4 1 0 0 1 1 1 1 Terminase DNA packaging enzyme HAUS-augmin3 PF14932.6 ETO11415.1 - 0.0083 15.7 12.5 0.013 15.1 12.5 1.3 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 DUF4407 PF14362.6 ETO11415.1 - 0.013 14.9 3.0 0.015 14.7 3.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 ETO11415.1 - 0.014 15.8 12.4 0.014 15.8 12.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) MRP-S26 PF14943.6 ETO11415.1 - 0.026 14.5 5.0 0.044 13.7 5.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S26 HMMR_N PF15905.5 ETO11415.1 - 0.032 13.7 12.9 0.051 13.0 12.9 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal ERM PF00769.19 ETO11415.1 - 0.043 13.6 8.6 0.068 13.0 8.6 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Tho2 PF11262.8 ETO11415.1 - 0.065 12.4 5.6 0.11 11.7 5.6 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Alpha-2-MRAP_C PF06401.11 ETO11415.1 - 0.097 12.6 7.9 0.16 12.0 7.9 1.2 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, C-terminal domain DUF1640 PF07798.11 ETO11415.1 - 0.2 11.7 9.8 0.36 10.9 9.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) OmpH PF03938.14 ETO11415.1 - 0.22 11.9 10.7 0.37 11.1 10.7 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 ETO11415.1 - 0.28 10.6 14.2 0.67 9.4 14.3 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 PCRF PF03462.18 ETO11415.1 - 0.4 10.5 6.7 0.74 9.6 6.7 1.4 1 0 0 1 1 1 0 PCRF domain HalX PF08663.10 ETO11415.1 - 0.48 10.8 7.5 0.37 11.1 5.5 1.9 2 0 0 2 2 1 0 HalX domain APG6_N PF17675.1 ETO11415.1 - 0.51 10.9 13.6 1.2 9.7 13.6 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region AATF-Che1 PF13339.6 ETO11415.1 - 0.73 10.5 9.8 0.66 10.7 7.9 1.9 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor FapA PF03961.13 ETO11415.1 - 0.78 8.3 6.5 1.2 7.7 6.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0242 PF06785.11 ETO11415.1 - 0.81 9.8 12.4 1.6 8.8 12.4 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Cnn_1N PF07989.11 ETO11415.1 - 1 9.6 12.3 3.8 7.7 3.6 2.9 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Seryl_tRNA_N PF02403.22 ETO11415.1 - 1.5 9.1 11.0 4.3 7.6 8.1 2.5 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain bZIP_1 PF00170.21 ETO11415.1 - 1.9 8.7 14.2 6.3 7.0 2.1 3.9 2 1 2 4 4 4 0 bZIP transcription factor FAM76 PF16046.5 ETO11415.1 - 7.3 5.9 9.8 11 5.2 9.8 1.3 1 0 0 1 1 1 0 FAM76 protein DUF1664 PF07889.12 ETO11415.1 - 9.3 6.3 9.3 4.8 7.2 7.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ETO11415.1 - 9.9 4.9 16.3 3.7 6.3 13.5 1.6 2 0 0 2 2 2 0 Spc7 kinetochore protein BT1 PF03092.16 ETO11416.1 - 7e-11 41.0 29.4 2.7e-08 32.5 19.6 3.5 3 1 0 3 3 3 3 BT1 family Phage_holin_8 PF16931.5 ETO11416.1 - 8.5 6.4 8.9 1.5 8.8 0.6 3.3 4 0 0 4 4 4 0 Putative phage holin Rad51 PF08423.11 ETO11417.1 - 9e-104 346.2 0.0 1.4e-103 345.6 0.0 1.2 1 0 0 1 1 1 1 Rad51 RecA PF00154.21 ETO11417.1 - 9e-11 41.7 0.1 1.3e-10 41.2 0.1 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 ETO11417.1 - 3.7e-10 39.5 0.3 1.6e-09 37.5 0.0 2.1 3 0 0 3 3 3 1 KaiC AAA_25 PF13481.6 ETO11417.1 - 4.4e-07 29.7 0.0 6.7e-07 29.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain HHH_5 PF14520.6 ETO11417.1 - 9.6e-05 22.9 0.1 0.00024 21.7 0.1 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix domain AAA_22 PF13401.6 ETO11417.1 - 0.0024 18.1 0.0 0.0054 17.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ETO11417.1 - 0.013 15.2 0.0 0.028 14.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ETO11417.1 - 0.058 13.8 0.0 0.14 12.5 0.0 1.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATP-synt_ab PF00006.25 ETO11417.1 - 0.16 11.6 0.3 0.26 10.9 0.3 1.5 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain Peptidase_C14 PF00656.22 ETO11420.1 - 7.9e-12 45.6 0.5 7.9e-12 45.6 0.5 2.0 2 0 0 2 2 2 1 Caspase domain Kelch_5 PF13854.6 ETO11420.1 - 0.0015 18.4 3.7 0.16 12.0 0.6 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO11420.1 - 0.007 16.6 0.5 0.35 11.2 0.2 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO11420.1 - 0.015 15.3 0.6 0.42 10.6 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO11420.1 - 0.03 14.3 1.3 0.57 10.3 0.1 3.6 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO11420.1 - 0.034 13.7 1.1 0.17 11.5 0.1 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO11420.1 - 0.1 12.9 0.0 0.41 11.0 0.0 2.1 1 0 0 1 1 1 0 Galactose oxidase, central domain PAM2 PF07145.15 ETO11421.1 - 0.0019 17.8 2.9 0.0019 17.8 2.9 3.3 3 0 0 3 3 3 1 Ataxin-2 C-terminal region WD40 PF00400.32 ETO11422.1 - 2.9e-51 170.3 11.2 3.7e-10 40.2 0.0 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11422.1 - 2.1e-20 72.8 0.7 0.00099 19.4 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11422.1 - 2.1e-11 43.4 2.8 0.0076 15.3 0.3 5.0 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11422.1 - 2.7e-09 36.8 0.5 4.1e-05 23.1 0.2 3.3 2 2 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO11422.1 - 1.8e-08 34.1 2.4 0.076 13.0 0.1 5.3 6 0 0 6 6 5 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO11422.1 - 5.5e-08 32.9 0.1 0.07 13.0 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO11422.1 - 8.4e-06 24.7 2.7 0.45 9.1 0.0 3.9 2 2 0 3 3 3 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO11422.1 - 5e-05 22.8 0.8 1.4 8.1 0.0 4.1 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO11422.1 - 0.00098 18.0 1.1 0.67 8.6 0.2 2.6 2 1 0 2 2 2 2 Nup133 N terminal like DPPIV_N PF00930.21 ETO11422.1 - 0.0018 17.1 0.0 4.4 5.9 0.0 3.2 2 2 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cytochrom_D1 PF02239.16 ETO11422.1 - 0.0076 14.8 0.0 0.2 10.1 0.0 2.5 1 1 1 3 3 3 2 Cytochrome D1 heme domain BBS2_Mid PF14783.6 ETO11422.1 - 0.021 14.9 2.7 8.4 6.5 0.2 3.7 3 2 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region nos_propeller PF18764.1 ETO11422.1 - 0.028 14.3 0.0 11 6.1 0.0 3.2 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat Proteasome_A_N PF10584.9 ETO11422.1 - 0.043 13.5 6.1 8.6 6.2 0.0 5.0 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF1797 PF08796.10 ETO11422.1 - 0.053 13.6 0.0 43 4.3 0.0 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF1797) HPS3_N PF14761.6 ETO11422.1 - 0.078 12.5 0.0 0.48 9.9 0.0 2.1 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 3 MyTH4 PF00784.17 ETO11423.1 - 0.1 13.1 2.5 0.61 10.6 0.0 2.5 1 1 1 2 2 2 0 MyTH4 domain Uteroglobin PF01099.17 ETO11424.1 - 0.93 9.9 3.4 21 5.5 0.4 3.0 3 0 0 3 3 3 0 Uteroglobin family Orf78 PF06024.12 ETO11426.1 - 0.013 15.8 1.1 0.048 13.9 1.1 2.1 1 1 0 1 1 1 0 Orf78 (ac78) Menin PF05053.13 ETO11426.1 - 10 4.4 9.7 14 3.9 9.7 1.1 1 0 0 1 1 1 0 Menin PUB PF09409.10 ETO11427.1 - 7.5e-07 29.0 0.0 1.8e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 PUB domain zf-RanBP PF00641.18 ETO11427.1 - 0.0074 15.6 0.4 0.0074 15.6 0.4 1.6 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ETO11427.1 - 0.016 15.3 0.3 0.063 13.3 0.1 2.0 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 ETO11427.1 - 0.017 14.5 0.8 0.06 12.8 0.8 2.0 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain RasGEF PF00617.19 ETO11428.1 - 2.7e-19 70.0 4.7 2.3e-11 44.2 0.2 3.0 2 2 1 3 3 3 2 RasGEF domain RasGEF_N PF00618.20 ETO11428.1 - 3.4e-07 30.5 0.5 8.2e-07 29.2 0.5 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif Vasculin PF15337.6 ETO11428.1 - 0.0032 18.3 0.9 0.0071 17.2 0.4 1.9 1 1 0 1 1 1 1 Vascular protein family Vasculin-like 1 Gag_p17 PF00540.18 ETO11429.1 - 0.018 15.0 0.2 0.028 14.4 0.2 1.4 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) Interfer-bind PF09294.10 ETO11434.1 - 0.15 12.4 1.8 0.22 11.9 1.8 1.3 1 1 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III CAP_GLY PF01302.25 ETO11435.1 - 2.5e-12 46.6 0.3 4.4e-12 45.8 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain Sina PF03145.16 ETO11437.1 - 6e-05 23.1 0.4 6e-05 23.1 0.4 2.0 2 0 0 2 2 2 1 Seven in absentia protein family Ogr_Delta PF04606.12 ETO11437.1 - 6.3e-05 22.9 0.6 0.00027 20.8 0.0 2.5 2 0 0 2 2 2 1 Ogr/Delta-like zinc finger RasGEF PF00617.19 ETO11438.1 - 8.9e-28 97.7 0.2 1.6e-27 96.8 0.2 1.4 1 0 0 1 1 1 1 RasGEF domain NST1 PF13945.6 ETO11440.1 - 0.41 10.7 10.4 0.5 10.5 10.4 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator WD40 PF00400.32 ETO11441.1 - 4.9e-70 229.7 22.7 1.1e-10 41.8 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11441.1 - 3.4e-22 78.5 1.8 0.0018 18.5 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11441.1 - 1.2e-15 57.3 0.0 0.016 14.2 0.0 6.4 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO11441.1 - 9.2e-14 50.7 0.1 1.9e-07 30.0 0.0 3.0 2 1 1 3 3 3 3 Cytochrome D1 heme domain eIF2A PF08662.11 ETO11441.1 - 2.1e-10 40.8 0.0 0.0028 17.6 0.0 3.6 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO11441.1 - 4.8e-09 35.9 4.6 3.4 7.7 0.0 7.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO11441.1 - 9.3e-09 34.5 3.2 0.86 8.2 0.2 5.2 3 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11441.1 - 2e-08 33.9 0.1 0.084 12.2 0.0 4.3 2 2 2 4 4 4 3 WD40-like domain Nucleoporin_N PF08801.11 ETO11441.1 - 3.6e-06 26.0 5.3 0.025 13.3 0.2 4.5 1 1 4 5 5 5 2 Nup133 N terminal like DUF5570 PF17731.1 ETO11441.1 - 8.8e-06 25.8 1.3 1.3 9.1 0.0 5.1 1 1 3 5 5 5 1 Family of unknown function (DUF5570) VID27 PF08553.10 ETO11441.1 - 0.024 13.7 0.1 0.87 8.6 0.0 3.0 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain PQQ PF01011.21 ETO11441.1 - 0.032 14.2 0.0 26 5.0 0.0 3.6 4 0 0 4 4 4 0 PQQ enzyme repeat Frtz PF11768.8 ETO11441.1 - 0.055 11.8 0.0 1.9 6.7 0.0 2.9 3 1 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz nos_propeller PF18764.1 ETO11441.1 - 0.1 12.5 0.1 23 5.0 0.0 4.1 6 0 0 6 6 6 0 Nitrous oxide reductase propeller repeat Proteasome_A_N PF10584.9 ETO11441.1 - 5.3 6.8 10.9 17 5.2 0.0 5.0 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF5619 PF18505.1 ETO11442.1 - 0.03 14.3 0.1 0.04 13.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5619) PGA2 PF07543.12 ETO11443.1 - 0.63 10.0 4.1 1.2 9.2 4.1 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 RhoGAP PF00620.27 ETO11444.1 - 0.0079 16.0 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain Nup188 PF10487.9 ETO11445.1 - 0.011 13.7 1.3 0.012 13.5 1.3 1.2 1 0 0 1 1 1 0 Nucleoporin subcomplex protein binding to Pom34 CLASP_N PF12348.8 ETO11446.1 - 0.00034 20.3 0.0 0.36 10.3 0.0 2.5 3 0 0 3 3 3 2 CLASP N terminal Cnd1 PF12717.7 ETO11446.1 - 0.00081 19.5 0.0 2.2 8.3 0.0 2.8 3 0 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 DNA_pol_phi PF04931.13 ETO11446.1 - 2.1 6.4 7.0 12 3.9 0.0 2.0 2 0 0 2 2 2 0 DNA polymerase phi Kelch_2 PF07646.15 ETO11447.1 - 1.4e-05 24.9 3.0 0.013 15.5 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO11447.1 - 3.4e-05 23.7 0.0 2.5 8.2 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO11447.1 - 0.0015 18.7 2.3 18 5.8 0.0 5.2 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO11447.1 - 0.014 15.0 2.1 15 5.2 0.0 4.2 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO11448.1 - 2.1e-08 34.6 1.0 4e-08 33.8 1.0 1.5 1 1 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO11448.1 - 0.065 11.9 0.2 0.083 11.5 0.1 1.2 1 1 0 1 1 1 0 Nucleoporin Nup120/160 AA_permease PF00324.21 ETO11450.1 - 3.9e-25 88.4 21.0 6.2e-25 87.7 21.0 1.3 1 0 0 1 1 1 1 Amino acid permease SLC12 PF03522.15 ETO11450.1 - 6.4e-11 41.9 0.0 8.1e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 Spc7 PF08317.11 ETO11451.1 - 0.00065 18.7 5.6 0.00065 18.7 5.6 1.5 2 0 0 2 2 2 1 Spc7 kinetochore protein DUF4815 PF16075.5 ETO11451.1 - 0.016 13.5 0.1 0.021 13.2 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4815) Noelin-1 PF12308.8 ETO11451.1 - 0.024 14.6 1.3 0.077 13.0 1.3 2.0 1 0 0 1 1 1 0 Neurogenesis glycoprotein Phage_GPO PF05929.11 ETO11451.1 - 0.043 13.5 4.8 0.033 13.8 3.2 1.7 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase GCN5L1 PF06320.13 ETO11451.1 - 0.12 12.5 5.5 1.5 9.0 1.0 2.7 1 1 1 2 2 2 0 GCN5-like protein 1 (GCN5L1) COMP PF11598.8 ETO11451.1 - 0.13 12.7 1.3 4.1 8.0 0.1 2.7 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein Phage_GP20 PF06810.11 ETO11451.1 - 0.14 12.0 11.1 0.076 12.8 8.8 1.8 2 0 0 2 2 2 0 Phage minor structural protein GP20 DUF3450 PF11932.8 ETO11451.1 - 0.16 11.3 7.2 0.28 10.4 7.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 ETO11451.1 - 0.24 11.6 11.7 0.49 10.6 11.7 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 ETO11451.1 - 0.38 11.2 13.2 0.22 12.0 11.1 1.6 2 0 0 2 2 2 0 Fez1 FapA PF03961.13 ETO11451.1 - 0.39 9.3 9.6 0.13 10.9 7.0 1.6 2 0 0 2 2 2 0 Flagellar Assembly Protein A HDV_ag PF01517.18 ETO11451.1 - 0.61 9.9 4.2 0.96 9.2 4.2 1.3 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen zf-C4H2 PF10146.9 ETO11451.1 - 0.64 10.3 9.6 0.35 11.1 7.7 1.6 2 0 0 2 2 1 0 Zinc finger-containing protein Bcr-Abl_Oligo PF09036.10 ETO11451.1 - 0.88 9.6 5.5 1 9.4 1.6 2.8 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain HIP1_clath_bdg PF16515.5 ETO11451.1 - 1.2 9.8 13.2 21 5.8 13.0 2.7 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 APG6_N PF17675.1 ETO11451.1 - 1.2 9.7 15.6 0.25 11.9 9.0 2.3 2 1 1 3 3 3 0 Apg6 coiled-coil region Fzo_mitofusin PF04799.13 ETO11451.1 - 1.3 8.5 7.9 1.6 8.2 4.7 2.5 2 1 0 2 2 2 0 fzo-like conserved region Syntaxin-6_N PF09177.11 ETO11451.1 - 1.6 9.3 9.5 4 8.1 6.8 2.6 2 1 1 3 3 3 0 Syntaxin 6, N-terminal TPR_MLP1_2 PF07926.12 ETO11451.1 - 2 8.5 16.4 0.13 12.3 9.4 2.3 2 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein SlyX PF04102.12 ETO11451.1 - 2.1 9.0 8.0 3 8.5 0.7 3.3 1 1 2 3 3 3 0 SlyX DUF4407 PF14362.6 ETO11451.1 - 2.2 7.6 9.4 0.46 9.8 5.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ETO11451.1 - 2.2 8.5 14.1 0.66 10.2 7.2 2.4 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF2203 PF09969.9 ETO11451.1 - 2.2 9.0 8.6 2.4 8.9 4.6 2.4 2 1 1 3 3 2 0 Uncharacterized conserved protein (DUF2203) BCDHK_Adom3 PF10436.9 ETO11451.1 - 2.6 7.8 6.1 5.6 6.8 6.1 1.7 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase COG2 PF06148.11 ETO11451.1 - 2.9 8.0 8.7 0.93 9.6 3.8 2.3 2 1 1 3 3 2 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1664 PF07889.12 ETO11451.1 - 4.7 7.3 8.3 10 6.2 6.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FlxA PF14282.6 ETO11451.1 - 5.8 7.0 18.3 1.1 9.3 11.2 2.7 2 1 1 3 3 2 0 FlxA-like protein DUF4140 PF13600.6 ETO11451.1 - 6.3 7.3 9.2 2.5 8.6 0.4 2.9 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) SPRY PF00622.28 ETO11452.1 - 8.7e-06 25.9 0.1 2.7e-05 24.3 0.1 1.8 1 0 0 1 1 1 1 SPRY domain Pox_Ag35 PF03286.14 ETO11452.1 - 0.035 13.9 6.4 0.08 12.7 6.4 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein LisH PF08513.11 ETO11452.1 - 0.05 13.6 0.0 0.14 12.1 0.0 1.9 1 0 0 1 1 1 0 LisH BTK PF00779.19 ETO11453.1 - 0.00014 21.6 3.1 0.00045 20.0 3.1 1.8 1 1 0 1 1 1 1 BTK motif RTP PF02334.16 ETO11453.1 - 0.063 13.9 1.1 0.11 13.1 1.1 1.5 1 0 0 1 1 1 0 Replication terminator protein DUF3139 PF11337.8 ETO11453.1 - 0.35 11.5 2.3 19 6.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) DUF4746 PF15928.5 ETO11454.1 - 0.15 11.4 10.1 0.18 11.2 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4820 PF16091.5 ETO11454.1 - 0.52 9.7 6.9 0.72 9.2 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Nop14 PF04147.12 ETO11454.1 - 0.72 8.0 16.5 0.92 7.6 16.5 1.2 1 0 0 1 1 1 0 Nop14-like family Atrophin-1 PF03154.15 ETO11454.1 - 0.74 8.0 2.4 0.9 7.7 2.4 1.2 1 0 0 1 1 1 0 Atrophin-1 family Zip PF02535.22 ETO11454.1 - 1.9 7.6 8.4 2.6 7.2 8.4 1.3 1 1 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO11454.1 - 3.2 6.4 7.2 4.1 6.1 7.2 1.2 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 ETO11454.1 - 5.2 6.1 8.8 6 5.9 8.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Pkinase PF00069.25 ETO11455.1 - 3.1e-23 82.5 0.1 7.7e-23 81.2 0.1 1.7 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11455.1 - 6.7e-05 22.3 0.0 0.00017 21.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4140 PF13600.6 ETO11455.1 - 0.36 11.3 3.1 9.8 6.7 0.2 2.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4519 PF15012.6 ETO11455.1 - 2.5 8.4 5.0 7.9 6.7 5.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) DUF4898 PF16239.5 ETO11457.1 - 0.004 17.1 1.0 0.0097 15.8 0.1 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4898) DUF3682 PF12446.8 ETO11458.1 - 0.053 14.0 5.1 0.13 12.7 5.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) FAM176 PF14851.6 ETO11458.1 - 0.34 10.6 1.8 0.85 9.3 1.8 1.6 1 0 0 1 1 1 0 FAM176 family Pyr_redox_2 PF07992.14 ETO11459.1 - 3.2e-10 39.7 0.0 3.9e-09 36.2 0.0 2.0 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO11459.1 - 0.053 12.8 0.0 0.98 8.6 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UCH PF00443.29 ETO11460.1 - 1.7e-22 80.2 0.6 7.4e-22 78.1 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO11460.1 - 6.4e-10 39.1 0.1 1.7e-09 37.7 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ATPase_2 PF01637.18 ETO11460.1 - 0.00067 19.6 1.0 0.0032 17.4 1.0 2.2 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ETO11460.1 - 0.033 14.7 0.0 0.12 12.9 0.0 1.9 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ETO11460.1 - 0.035 14.4 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETO11460.1 - 0.043 13.5 0.0 0.18 11.5 0.0 2.1 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ETO11460.1 - 0.055 13.2 0.0 0.14 11.9 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_29 PF13555.6 ETO11460.1 - 0.069 12.9 0.0 0.17 11.7 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zeta_toxin PF06414.12 ETO11460.1 - 0.091 12.0 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin AAA_16 PF13191.6 ETO11460.1 - 0.14 12.5 0.0 0.28 11.5 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain AAA_14 PF13173.6 ETO11460.1 - 0.15 12.1 4.8 0.63 10.1 0.1 3.5 3 0 0 3 3 3 0 AAA domain AHD PF17793.1 ETO11461.1 - 0.054 13.3 1.2 0.16 11.8 0.6 2.2 1 1 0 1 1 1 0 ANC1 homology domain (AHD) Ureide_permease PF07168.11 ETO11461.1 - 0.36 9.5 2.6 0.59 8.8 2.6 1.3 1 0 0 1 1 1 0 Ureide permease RNase_H2-Ydr279 PF09468.10 ETO11461.1 - 5.3 7.2 8.8 12 6.0 3.4 2.3 2 1 0 2 2 2 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Focal_AT PF03623.13 ETO11467.1 - 0.86 9.6 5.3 7.6 6.5 0.2 4.0 3 0 0 3 3 3 0 Focal adhesion targeting region DUF3206 PF11472.8 ETO11467.1 - 2.5 8.1 7.0 1.4 8.9 0.1 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF3206) Presenilin PF01080.17 ETO11468.1 - 0.12 11.2 7.8 0.12 11.1 7.8 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO11468.1 - 0.26 11.3 7.5 0.28 11.2 7.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PIN_12 PF16289.5 ETO11468.1 - 0.29 11.6 17.4 0.36 11.3 17.4 1.2 1 0 0 1 1 1 0 PIN domain Membralin PF09746.9 ETO11468.1 - 0.44 9.5 7.9 0.45 9.5 7.9 1.1 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 ETO11468.1 - 1.1 8.0 7.9 1 8.1 7.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 ETO11468.1 - 1.4 8.0 5.6 1.4 8.0 5.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 ETO11468.1 - 2 8.7 29.2 2.7 8.3 29.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 ETO11468.1 - 2.3 8.3 7.7 2.5 8.2 7.7 1.1 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.12 ETO11468.1 - 2.5 8.3 20.5 2.9 8.1 20.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family V_ATPase_I PF01496.19 ETO11468.1 - 2.5 5.9 8.8 2.3 6.0 8.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4551 PF15087.6 ETO11468.1 - 6.4 5.5 12.5 7.2 5.3 12.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SLC12 PF03522.15 ETO11468.1 - 7.6 5.4 17.9 8.8 5.2 17.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NARP1 PF12569.8 ETO11468.1 - 8.9 5.1 26.7 12 4.6 26.7 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4569 PF15133.6 ETO11468.1 - 9.2 5.9 12.6 10 5.8 12.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) RRM_1 PF00076.22 ETO11469.1 - 1.7e-18 66.2 0.0 5.1e-18 64.7 0.0 1.9 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TLD PF07534.16 ETO11469.1 - 9e-13 48.6 0.0 2.2e-06 27.9 0.0 2.8 2 0 0 2 2 2 2 TLD RabGAP-TBC PF00566.18 ETO11469.1 - 4.8e-05 23.1 0.1 4.8e-05 23.1 0.1 3.1 3 0 0 3 3 3 2 Rab-GTPase-TBC domain UPF0242 PF06785.11 ETO11470.1 - 3.3 7.8 20.1 4.1 7.5 20.1 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ion_trans PF00520.31 ETO11471.1 - 2.6e-05 23.6 15.5 3.5e-05 23.1 15.5 1.3 1 0 0 1 1 1 1 Ion transport protein WD40 PF00400.32 ETO11473.1 - 4.9e-62 204.4 14.8 2.9e-09 37.4 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11473.1 - 1.9e-20 73.0 2.2 0.0053 17.0 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11473.1 - 4.8e-10 39.2 0.1 0.0013 18.2 0.0 3.8 1 1 2 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO11473.1 - 3e-09 36.3 0.4 1.2 8.0 0.0 5.9 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO11473.1 - 1.2e-06 28.5 0.3 0.068 13.0 0.0 3.3 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO11473.1 - 1.6e-05 23.8 5.2 1 7.9 0.0 5.0 3 3 3 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO11473.1 - 0.00083 18.0 1.0 1.8 7.0 0.0 3.4 1 1 4 5 5 5 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO11473.1 - 0.0012 18.8 2.1 43 4.2 0.0 5.7 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO11473.1 - 0.0013 17.6 1.8 0.66 8.7 0.0 3.7 1 1 2 4 4 4 1 Nup133 N terminal like BBS2_Mid PF14783.6 ETO11473.1 - 0.026 14.5 2.7 57 3.8 0.0 5.0 5 2 1 6 6 6 0 Ciliary BBSome complex subunit 2, middle region DUF5570 PF17731.1 ETO11473.1 - 0.051 13.7 0.4 12 6.0 0.1 3.9 3 2 1 4 4 4 0 Family of unknown function (DUF5570) Kelch_1 PF01344.25 ETO11474.1 - 1.6e-05 24.4 4.8 0.0085 15.7 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO11474.1 - 0.00025 20.9 4.1 0.48 10.5 0.1 4.3 4 0 0 4 4 4 2 Kelch motif B2-adapt-app_C PF09066.10 ETO11474.1 - 0.012 15.7 2.6 0.028 14.5 0.5 2.3 1 1 1 2 2 2 0 Beta2-adaptin appendage, C-terminal sub-domain Kelch_4 PF13418.6 ETO11474.1 - 0.013 15.5 0.6 3.7 7.6 0.0 4.0 5 0 0 5 5 5 0 Galactose oxidase, central domain SET PF00856.28 ETO11474.1 - 0.056 13.8 0.5 3.4 8.0 0.0 2.2 2 0 0 2 2 2 0 SET domain Eapp_C PF10238.9 ETO11474.1 - 0.068 13.3 11.4 2.2 8.3 5.5 2.5 2 0 0 2 2 2 0 E2F-associated phosphoprotein Presenilin PF01080.17 ETO11474.1 - 2.1 7.0 7.1 7 5.3 1.0 2.2 2 0 0 2 2 2 0 Presenilin Afi1 PF07792.12 ETO11474.1 - 3.9 7.9 11.2 3.3 8.2 1.2 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking AAA_23 PF13476.6 ETO11474.1 - 4.5 7.7 19.2 4.5 7.7 9.3 2.3 2 0 0 2 2 2 0 AAA domain FAM176 PF14851.6 ETO11474.1 - 5.2 6.7 14.3 0.89 9.2 1.3 2.3 2 0 0 2 2 2 0 FAM176 family AAA_11 PF13086.6 ETO11474.1 - 6.3 6.5 12.3 7.1 6.3 5.2 2.3 2 0 0 2 2 2 0 AAA domain TPR_2 PF07719.17 ETO11475.1 - 0.00012 21.9 6.4 0.015 15.4 0.2 3.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11475.1 - 0.00014 21.5 9.9 0.0068 16.2 0.3 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11475.1 - 0.00042 20.3 0.3 0.00042 20.3 0.3 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11475.1 - 0.0022 18.2 1.5 0.14 12.6 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat EST1_DNA_bind PF10373.9 ETO11475.1 - 0.012 15.1 0.3 0.04 13.4 0.0 1.9 2 0 0 2 2 2 0 Est1 DNA/RNA binding domain MitMem_reg PF13012.6 ETO11475.1 - 0.013 16.0 2.5 0.47 10.9 2.5 2.3 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function TPR_11 PF13414.6 ETO11475.1 - 0.031 14.0 1.1 0.24 11.1 0.0 2.7 3 1 0 3 3 3 0 TPR repeat UPF0061 PF02696.14 ETO11475.1 - 0.044 12.6 1.3 0.055 12.2 1.3 1.1 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family TPR_12 PF13424.6 ETO11475.1 - 0.54 10.6 4.1 12 6.3 0.0 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO11477.1 - 1.3e-44 149.2 27.4 2.4e-08 34.5 1.3 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11477.1 - 5.6e-16 58.6 3.1 0.00043 20.5 0.2 6.0 3 2 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11477.1 - 1.6e-11 43.6 10.0 0.00042 19.1 0.8 5.3 1 1 4 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO11477.1 - 3.5e-08 33.6 6.8 0.0013 18.7 0.9 3.8 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO11477.1 - 5.8e-08 32.4 8.4 0.0011 18.4 0.7 4.3 2 2 1 4 4 4 3 WD40-like domain DUF4221 PF13970.6 ETO11477.1 - 0.065 12.8 8.5 0.023 14.3 1.6 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF4221) DUF4979 PF16351.5 ETO11477.1 - 0.26 11.5 4.3 19 5.5 0.1 4.1 1 1 2 4 4 4 0 Domain of unknown function (DUF4979) BRCT_2 PF16589.5 ETO11478.1 - 0.24 11.8 2.4 0.26 11.7 1.3 1.7 1 1 1 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain zf-TRAF PF02176.18 ETO11479.1 - 2.6e-06 28.0 1.3 5.2e-06 27.0 1.3 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger Sina PF03145.16 ETO11479.1 - 0.023 14.6 1.9 1.1 9.2 0.0 2.1 1 1 1 2 2 2 0 Seven in absentia protein family Ly49 PF08391.10 ETO11479.1 - 0.047 14.1 0.3 0.074 13.4 0.3 1.4 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region CENP-M PF11111.8 ETO11481.1 - 0.027 13.7 0.0 0.032 13.4 0.0 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) WD40 PF00400.32 ETO11482.1 - 1.3e-08 35.3 5.2 0.049 14.5 0.0 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat EpoR_lig-bind PF09067.10 ETO11482.1 - 0.0014 18.8 1.6 0.12 12.6 0.5 2.8 3 0 0 3 3 3 1 Erythropoietin receptor, ligand binding Ge1_WD40 PF16529.5 ETO11482.1 - 0.0023 17.0 0.0 0.066 12.2 0.0 2.6 2 1 0 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 ETO11483.1 - 1.2e-11 44.9 8.0 0.017 15.9 0.0 6.2 5 1 0 5 5 5 4 WD domain, G-beta repeat SAM_2 PF07647.17 ETO11483.1 - 8.2e-09 35.4 0.1 1.9e-08 34.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO11483.1 - 5.4e-08 33.2 0.1 1.1e-07 32.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Nucleoporin_N PF08801.11 ETO11483.1 - 0.0015 17.4 3.7 0.0063 15.3 0.1 2.5 3 0 0 3 3 3 1 Nup133 N terminal like MraZ PF02381.18 ETO11483.1 - 0.0023 17.9 0.0 0.021 14.8 0.0 2.3 2 0 0 2 2 2 1 MraZ protein, putative antitoxin-like SAM_PNT PF02198.16 ETO11483.1 - 0.0028 17.6 0.0 0.013 15.4 0.0 2.0 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain DUF3642 PF12182.8 ETO11483.1 - 0.068 13.5 0.5 17 5.8 0.0 2.8 2 0 0 2 2 2 0 Bacterial lipoprotein DUF1681 PF07933.14 ETO11484.1 - 4.5e-15 55.6 0.0 1.2e-14 54.3 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) BSD PF03909.17 ETO11484.1 - 2.7e-08 33.7 0.8 2.7e-08 33.7 0.8 1.9 2 0 0 2 2 2 1 BSD domain Cnd1_N PF12922.7 ETO11484.1 - 0.071 13.0 1.0 0.1 12.5 1.0 1.2 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term Mx_ML PF17536.2 ETO11486.1 - 0.047 13.4 0.6 0.16 11.6 0.0 2.1 2 0 0 2 2 2 0 Matrix and Matrix long proteins N-terminal TcdB_N PF12918.7 ETO11486.1 - 0.056 13.7 5.8 0.82 10.0 4.6 3.5 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain dCache_1 PF02743.18 ETO11486.1 - 1.1 8.9 11.9 5.7 6.6 5.9 2.6 2 0 0 2 2 2 0 Cache domain HOOK PF05622.12 ETO11487.1 - 0.0034 15.6 39.7 0.046 11.9 34.8 1.9 1 1 1 2 2 2 2 HOOK protein TMCO5 PF14992.6 ETO11487.1 - 0.023 14.3 2.4 0.023 14.3 2.4 2.1 1 1 1 2 2 2 0 TMCO5 family MAD PF05557.13 ETO11487.1 - 0.19 10.1 42.8 0.017 13.5 26.9 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF3800 PF12686.7 ETO11487.1 - 0.69 10.6 6.4 2.5 8.7 6.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF4407 PF14362.6 ETO11487.1 - 0.76 9.1 27.2 0.44 9.9 4.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 ETO11487.1 - 1.9 8.6 47.9 0.12 12.4 28.1 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein RPW8 PF05659.11 ETO11487.1 - 2.4 7.9 14.4 0.15 11.7 7.5 2.4 1 1 2 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Fez1 PF06818.15 ETO11487.1 - 3.3 8.1 37.5 20 5.6 28.8 2.4 1 1 1 2 2 2 0 Fez1 EzrA PF06160.12 ETO11487.1 - 4.6 5.3 34.0 1.7 6.7 22.3 2.2 1 1 0 2 2 2 0 Septation ring formation regulator, EzrA DUF724 PF05266.14 ETO11487.1 - 5.8 6.7 36.0 2.1 8.2 16.2 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF724) Cyclin_C_2 PF16899.5 ETO11487.1 - 6.8 7.1 8.0 1.7 9.0 4.0 2.1 2 0 0 2 2 2 0 Cyclin C-terminal domain DUF1664 PF07889.12 ETO11487.1 - 6.9 6.7 23.5 0.87 9.6 4.1 2.6 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) GAS PF13851.6 ETO11487.1 - 7 5.9 46.1 3.8 6.8 7.5 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding DUF4320 PF14208.6 ETO11487.1 - 7.5 6.7 7.6 2.6 8.1 4.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4320) CENP-F_leu_zip PF10473.9 ETO11487.1 - 8.1 6.5 49.1 14 5.7 22.8 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HTH_Mga PF08280.11 ETO11488.1 - 0.22 11.6 4.1 10 6.2 0.1 3.5 3 0 0 3 3 3 0 M protein trans-acting positive regulator (MGA) HTH domain DUF1840 PF08895.11 ETO11488.1 - 0.73 10.2 0.0 0.73 10.2 0.0 3.4 1 1 0 2 2 2 0 Domain of unknown function (DUF1840) MCC-bdg_PDZ PF10506.9 ETO11488.1 - 4.1 7.5 9.3 1.4 9.0 0.3 3.8 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Remorin_C PF03763.13 ETO11488.1 - 5.8 6.8 8.0 2 8.4 0.0 3.2 3 0 0 3 3 3 0 Remorin, C-terminal region zf-RING_2 PF13639.6 ETO11489.1 - 6.8e-07 29.5 4.4 6.8e-07 29.5 4.4 7.9 5 3 3 8 8 8 2 Ring finger domain zf-RING_UBOX PF13445.6 ETO11489.1 - 0.00083 19.3 0.6 0.00083 19.3 0.6 6.6 8 0 0 8 8 8 2 RING-type zinc-finger zf-RING_11 PF17123.5 ETO11489.1 - 0.0026 17.5 2.3 0.0026 17.5 2.3 4.9 4 1 0 4 4 4 1 RING-like zinc finger zf-C3HC4 PF00097.25 ETO11489.1 - 0.0043 16.9 0.7 0.0043 16.9 0.7 8.4 6 4 1 7 7 7 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO11489.1 - 0.0085 15.9 0.7 0.0085 15.9 0.7 8.1 9 0 0 9 9 9 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO11489.1 - 0.009 15.9 0.7 0.009 15.9 0.7 8.8 6 3 1 7 7 7 2 zinc-RING finger domain Presenilin PF01080.17 ETO11489.1 - 4.3 6.0 4.6 5.8 5.6 4.6 1.1 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO11489.1 - 4.5 5.5 15.7 6.1 5.1 15.7 1.1 1 0 0 1 1 1 0 Menin G-alpha PF00503.20 ETO11490.1 - 2e-88 296.9 18.9 2.5e-88 296.6 18.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO11490.1 - 8.7e-09 35.1 8.3 3.1e-05 23.5 0.1 4.2 3 1 1 4 4 4 2 ADP-ribosylation factor family Roc PF08477.13 ETO11490.1 - 0.0015 18.7 3.9 0.28 11.4 0.1 3.6 3 1 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 ETO11490.1 - 0.042 13.4 3.3 3.7 7.0 0.6 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain Ion_trans_N PF08412.10 ETO11490.1 - 0.13 11.9 0.0 2.6 7.7 0.0 2.6 2 0 0 2 2 2 0 Ion transport protein N-terminal HEAT PF02985.22 ETO11491.1 - 2.2e-14 52.3 0.0 0.024 14.9 0.0 5.1 5 0 0 5 5 5 4 HEAT repeat HEAT_2 PF13646.6 ETO11491.1 - 1.6e-10 41.2 0.0 2.2e-05 24.8 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETO11491.1 - 4.6e-10 39.8 3.8 6.5e-05 23.0 2.3 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETO11491.1 - 2e-06 27.6 1.1 0.0029 17.2 0.0 2.5 1 1 1 2 2 2 2 CLASP N terminal HEAT_EZ PF13513.6 ETO11491.1 - 4.4e-06 27.1 0.0 0.13 12.8 0.0 4.2 2 1 2 4 4 4 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO11491.1 - 7.7e-06 26.4 0.4 0.018 15.6 0.1 2.8 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO11491.1 - 7.9e-06 25.7 5.5 0.018 14.9 0.4 4.0 1 1 4 5 5 5 3 TATA-binding protein interacting (TIP20) ThylakoidFormat PF11264.8 ETO11491.1 - 0.001 18.8 0.6 2.6 7.7 0.0 2.9 1 1 2 3 3 3 2 Thylakoid formation protein DUF5071 PF16804.5 ETO11491.1 - 0.0023 18.2 0.3 0.0044 17.3 0.1 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5071) RTP1_C1 PF10363.9 ETO11491.1 - 0.0027 17.9 0.1 4 7.6 0.0 2.6 1 1 1 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 XkdW PF09636.10 ETO11491.1 - 0.0092 16.1 7.9 2 8.6 0.1 3.9 2 1 2 4 4 4 1 XkdW protein Med23 PF11573.8 ETO11491.1 - 0.018 12.8 1.7 0.24 9.0 0.5 2.1 1 1 1 2 2 2 0 Mediator complex subunit 23 Dopey_N PF04118.14 ETO11491.1 - 0.022 13.9 0.8 0.89 8.6 0.2 2.9 1 1 1 2 2 2 0 Dopey, N-terminal Muted PF14942.6 ETO11491.1 - 0.023 15.0 4.1 0.031 14.6 2.1 2.0 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein TAN PF11640.8 ETO11491.1 - 0.026 14.7 3.9 22 5.1 3.6 4.3 1 1 0 1 1 1 0 Telomere-length maintenance and DNA damage repair AF0941-like PF14591.6 ETO11491.1 - 0.045 14.3 6.5 0.3 11.6 1.4 2.9 2 1 1 3 3 3 0 AF0941-like HR1 PF02185.16 ETO11491.1 - 0.051 13.7 1.1 0.46 10.6 0.2 2.7 2 1 1 3 3 3 0 Hr1 repeat MMS19_N PF14500.6 ETO11491.1 - 0.057 13.0 1.0 0.55 9.8 0.5 2.4 1 1 2 3 3 3 0 Dos2-interacting transcription regulator of RNA-Pol-II Syntaphilin PF15290.6 ETO11491.1 - 0.06 13.0 5.9 0.27 10.9 0.5 3.0 2 1 2 4 4 4 0 Golgi-localised syntaxin-1-binding clamp HSBP1 PF06825.12 ETO11491.1 - 0.067 13.1 0.6 0.18 11.7 0.2 2.0 2 1 0 2 2 1 0 Heat shock factor binding protein 1 MSP7_C PF12948.7 ETO11491.1 - 0.07 13.8 4.4 2.9 8.6 0.2 2.7 2 1 0 2 2 2 0 MSP7-like protein C-terminal domain DNA_alkylation PF08713.11 ETO11491.1 - 0.073 12.8 0.2 2.5 7.8 0.1 2.3 1 1 2 3 3 3 0 DNA alkylation repair enzyme Fer4_24 PF18109.1 ETO11491.1 - 0.073 13.4 0.6 44 4.5 0.0 4.2 5 0 0 5 5 5 0 Ferredoxin I 4Fe-4S cluster domain DUF5105 PF17118.5 ETO11491.1 - 0.1 12.4 4.3 9.5 5.9 0.0 3.7 2 2 3 5 5 5 0 Domain of unknown function (DUF5105) DUF3349 PF11829.8 ETO11491.1 - 0.17 12.7 4.6 3 8.7 0.7 3.6 2 2 2 4 4 3 0 Protein of unknown function (DUF3349) DUF445 PF04286.12 ETO11491.1 - 0.2 11.4 3.6 0.28 10.9 3.6 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) HBB PF06777.11 ETO11491.1 - 0.21 11.2 4.4 6 6.5 0.1 3.5 2 1 2 4 4 4 0 Helical and beta-bridge domain NLE PF08154.12 ETO11491.1 - 0.45 11.1 9.7 4.4 7.9 0.5 3.7 2 1 2 4 4 3 0 NLE (NUC135) domain SRX PF09201.10 ETO11491.1 - 0.56 10.0 3.5 7.1 6.5 0.3 3.3 3 2 1 4 4 4 0 SRX, signal recognition particle receptor alpha subunit UXS1_N PF11803.8 ETO11491.1 - 0.61 10.5 2.2 21 5.5 0.1 3.1 3 1 0 3 3 3 0 UDP-glucuronate decarboxylase N-terminal PRESAN PF09687.10 ETO11491.1 - 2 9.0 6.9 4.7 7.8 1.9 2.7 2 1 0 2 2 2 0 Plasmodium RESA N-terminal RNA_binding PF01877.17 ETO11492.1 - 0.0085 16.4 3.0 0.42 10.9 1.5 2.9 1 1 1 2 2 2 1 RNA binding HEAT_EZ PF13513.6 ETO11492.1 - 0.018 15.5 0.0 1.8 9.2 0.0 2.8 3 1 0 3 3 3 0 HEAT-like repeat zf-P11 PF03854.14 ETO11492.1 - 0.019 14.6 1.1 0.067 12.9 0.6 2.0 2 0 0 2 2 2 0 P-11 zinc finger SpecificRecomb PF10136.9 ETO11492.1 - 0.05 11.9 0.0 0.053 11.8 0.0 1.2 1 0 0 1 1 1 0 Site-specific recombinase TAN PF11640.8 ETO11492.1 - 0.063 13.4 1.0 0.18 12.0 0.2 1.9 1 1 1 2 2 2 0 Telomere-length maintenance and DNA damage repair MatC_N PF07158.11 ETO11493.1 - 0.099 12.7 8.2 0.17 11.9 7.7 1.6 1 1 1 2 2 2 0 Dicarboxylate carrier protein MatC N-terminus KASH PF10541.9 ETO11493.1 - 0.35 11.2 0.1 0.35 11.2 0.1 2.3 2 1 1 3 3 3 0 Nuclear envelope localisation domain PROCN PF08083.11 ETO11495.1 - 0.19 10.4 0.1 0.27 9.9 0.1 1.2 1 0 0 1 1 1 0 PROCN (NUC071) domain mRNA_stabil PF13929.6 ETO11496.1 - 0.011 14.7 5.1 0.011 14.7 4.5 1.3 1 1 0 1 1 1 0 mRNA stabilisation TPR_12 PF13424.6 ETO11499.1 - 1.5e-26 92.5 4.5 1.8e-14 53.8 1.8 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11499.1 - 9.3e-18 63.5 0.2 0.0002 21.1 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11499.1 - 2.9e-15 55.3 14.7 1.3e-05 24.8 0.2 4.8 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11499.1 - 1.8e-14 52.6 0.7 0.0019 18.1 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11499.1 - 5.5e-11 41.8 12.8 0.0028 17.8 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11499.1 - 5.2e-07 29.3 11.5 0.0017 18.4 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat RNA_pol_Rbc25 PF08292.12 ETO11499.1 - 0.0091 16.2 4.5 0.021 15.1 4.5 1.7 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Spt20 PF12090.8 ETO11499.1 - 0.015 14.9 19.8 0.037 13.6 19.8 1.6 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 ETO11499.1 - 0.089 12.8 17.1 0.12 12.3 17.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TPR_11 PF13414.6 ETO11499.1 - 0.29 10.9 10.6 0.31 10.7 0.0 4.3 4 0 0 4 4 4 0 TPR repeat DUF2722 PF10846.8 ETO11499.1 - 0.3 10.0 19.5 0.43 9.5 19.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Methyltransf_32 PF13679.6 ETO11499.1 - 0.38 10.7 5.6 0.81 9.7 5.6 1.5 1 0 0 1 1 1 0 Methyltransferase domain UPF0560 PF10577.9 ETO11499.1 - 0.58 8.6 10.4 0.82 8.1 10.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 TPR_17 PF13431.6 ETO11499.1 - 1 9.9 3.6 13 6.4 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat Presenilin PF01080.17 ETO11499.1 - 4.7 5.9 10.1 12 4.6 10.1 1.6 1 0 0 1 1 1 0 Presenilin TMEM51 PF15345.6 ETO11499.1 - 6.6 6.5 12.6 11 5.8 12.6 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Activator_LAG-3 PF11498.8 ETO11499.1 - 7.1 5.5 33.7 10 5.0 33.7 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 WD40 PF00400.32 ETO11500.1 - 0.0011 19.7 0.3 0.007 17.2 0.6 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO11501.1 - 2.3e-67 221.3 14.8 5.7e-10 39.6 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11501.1 - 1.1e-23 83.3 3.7 0.00013 22.2 0.0 6.8 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11501.1 - 3.7e-16 59.0 0.1 0.25 10.3 0.0 6.9 1 1 7 8 8 8 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO11501.1 - 5.2e-10 38.6 5.9 0.031 12.9 0.0 5.5 2 1 3 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO11501.1 - 7.1e-10 38.6 4.2 0.36 10.8 0.0 7.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO11501.1 - 4.8e-09 36.0 0.4 0.0091 15.4 0.1 3.9 1 1 3 4 4 4 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO11501.1 - 1.6e-06 27.4 0.8 0.0016 17.6 0.2 2.1 1 1 1 2 2 2 2 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO11501.1 - 6.2e-06 25.2 12.8 0.39 9.4 0.3 5.0 1 1 5 6 6 6 4 Nup133 N terminal like DUF5046 PF16465.5 ETO11501.1 - 0.0021 17.6 0.0 0.13 11.7 0.0 2.9 1 1 2 3 3 3 1 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 ETO11501.1 - 0.0054 15.3 0.2 2.1 6.8 0.0 2.7 1 1 1 3 3 3 2 Cytochrome D1 heme domain HPS6 PF15702.5 ETO11501.1 - 0.0065 14.5 0.0 3.5 5.5 0.0 3.5 1 1 2 4 4 4 1 Hermansky-Pudlak syndrome 6 protein Gmad1 PF10647.9 ETO11501.1 - 0.014 15.2 0.0 0.26 11.0 0.1 2.5 1 1 1 2 2 2 0 Lipoprotein LpqB beta-propeller domain PALB2_WD40 PF16756.5 ETO11501.1 - 0.026 13.5 6.6 0.045 12.7 0.1 3.9 2 1 4 6 6 6 0 Partner and localizer of BRCA2 WD40 domain DUF5449 PF17528.2 ETO11501.1 - 0.032 14.0 1.4 1.1 9.0 0.0 3.3 2 2 2 4 4 4 0 Family of unknown function (DUF5449) DUF1854 PF08909.11 ETO11501.1 - 0.037 13.8 1.6 1 9.2 0.0 3.1 2 1 2 4 4 4 0 Domain of unknown function (DUF1854) DUF5474 PF17568.2 ETO11501.1 - 0.047 13.8 0.3 2.3 8.4 0.1 3.4 3 1 1 4 4 4 0 Family of unknown function (DUF5474) Phage_CI_repr PF07022.13 ETO11501.1 - 0.052 13.7 0.0 12 6.1 0.0 3.1 4 0 0 4 4 3 0 Bacteriophage CI repressor helix-turn-helix domain SBD PF17882.1 ETO11501.1 - 0.057 13.2 1.6 18 5.2 0.0 4.2 1 1 4 5 5 5 0 OAA-family lectin sugar binding domain Proteasome_A_N PF10584.9 ETO11501.1 - 0.061 13.0 13.2 2.8 7.7 0.2 5.8 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO11501.1 - 0.066 13.2 0.0 1.2e+02 2.8 0.0 4.3 5 0 0 5 5 4 0 PQQ enzyme repeat NHL PF01436.21 ETO11501.1 - 0.11 12.6 0.6 20 5.5 0.0 3.7 4 0 0 4 4 3 0 NHL repeat Inhibitor_Mig-6 PF11555.8 ETO11502.1 - 0.061 13.4 0.0 0.1 12.7 0.0 1.3 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 DCP1 PF06058.13 ETO11503.1 - 0.08 12.9 0.4 11 6.0 0.0 2.3 2 0 0 2 2 2 0 Dcp1-like decapping family SecA_DEAD PF07517.14 ETO11504.1 - 0.00036 19.9 0.2 0.019 14.3 0.0 3.4 2 1 0 2 2 2 1 SecA DEAD-like domain DUF3921 PF13060.6 ETO11504.1 - 0.34 11.0 2.5 13 5.9 0.1 3.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3921) Synaptonemal_3 PF15191.6 ETO11504.1 - 1.8 8.4 6.5 0.88 9.4 0.1 4.1 3 0 0 3 3 3 0 Synaptonemal complex central element protein 3 T3SS_basalb_I PF17001.5 ETO11504.1 - 3.9 8.1 13.8 2.8 8.6 0.0 5.9 6 1 0 6 6 6 0 Type III secretion basal body protein I, YscI, HrpB, PscI Peptidase_M64 PF09471.10 ETO11505.1 - 0.0017 18.0 0.3 0.0021 17.6 0.3 1.1 1 0 0 1 1 1 1 IgA Peptidase M64 Mak10 PF04112.13 ETO11505.1 - 0.025 14.1 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase CrgA PF06781.12 ETO11505.1 - 0.031 14.3 0.2 0.053 13.6 0.2 1.3 1 0 0 1 1 1 0 Cell division protein CrgA TPR_2 PF07719.17 ETO11507.1 - 4e-13 48.4 4.2 0.0017 18.3 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11507.1 - 2e-11 44.0 0.6 0.00065 19.9 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11507.1 - 4.6e-11 42.0 11.8 0.22 11.8 0.0 6.1 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11507.1 - 1.3e-10 41.2 0.1 0.046 14.6 0.0 5.1 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO11507.1 - 5.5e-10 39.6 0.9 3.1e-06 27.6 0.1 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11507.1 - 9.7e-10 37.9 5.9 0.093 12.6 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat FAT PF02259.23 ETO11507.1 - 2.4e-08 33.6 2.8 0.00048 19.4 2.3 2.1 1 1 1 2 2 2 2 FAT domain TPR_16 PF13432.6 ETO11507.1 - 1.1e-07 32.4 0.0 0.00027 21.5 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11507.1 - 4.2e-07 29.9 0.1 0.0058 16.9 0.0 3.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_20 PF14561.6 ETO11507.1 - 1.2e-05 25.5 0.0 0.0005 20.4 0.0 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO11507.1 - 3.1e-05 24.0 0.3 0.0031 17.6 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11507.1 - 0.0001 22.1 0.2 32 4.9 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11507.1 - 0.00031 20.3 1.4 0.82 9.4 0.0 4.3 4 1 1 5 5 5 1 TPR repeat ANAPC3 PF12895.7 ETO11507.1 - 0.00035 20.8 1.6 0.011 15.9 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ETO11507.1 - 0.0035 17.1 6.5 7.2 6.6 0.0 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11508.1 - 4.9e-06 26.2 6.6 0.0043 17.1 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11508.1 - 0.00037 20.2 8.0 0.0055 16.5 0.4 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11508.1 - 0.0085 15.9 2.4 0.029 14.2 0.0 3.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11508.1 - 0.013 15.8 2.2 0.036 14.3 0.0 2.7 2 2 0 2 2 2 0 Tetratricopeptide repeat Ank_2 PF12796.7 ETO11508.1 - 0.013 16.1 1.4 0.036 14.7 0.4 2.1 1 1 1 2 2 2 0 Ankyrin repeats (3 copies) Kinesin PF00225.23 ETO11508.1 - 0.038 12.9 0.9 0.07 12.0 0.9 1.4 1 0 0 1 1 1 0 Kinesin motor domain TPR_16 PF13432.6 ETO11508.1 - 0.065 13.9 0.0 16 6.2 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat NOA36 PF06524.12 ETO11508.1 - 0.088 12.1 10.9 0.12 11.6 10.9 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2949 PF11165.8 ETO11508.1 - 0.16 12.3 1.1 0.58 10.5 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2949) TPR_8 PF13181.6 ETO11508.1 - 0.21 11.9 7.6 5.9 7.4 0.3 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat Spt20 PF12090.8 ETO11509.1 - 0.0058 16.3 18.7 0.0058 16.3 18.7 4.3 2 1 0 2 2 2 1 Spt20 family Metallophos PF00149.28 ETO11510.1 - 0.0026 18.3 0.0 0.0045 17.5 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase ATS3 PF06232.11 ETO11511.1 - 0.14 12.1 0.0 0.24 11.3 0.0 1.4 1 1 0 1 1 1 0 Embryo-specific protein 3, (ATS3) Mur_ligase_C PF02875.21 ETO11512.1 - 0.029 14.6 0.0 0.072 13.4 0.0 1.6 1 0 0 1 1 1 0 Mur ligase family, glutamate ligase domain DUF3464 PF11947.8 ETO11513.1 - 0.013 15.2 0.4 0.015 15.0 0.4 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2828 PF11443.8 ETO11513.1 - 0.031 12.4 1.4 0.033 12.3 1.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Peroxin-13_N PF04088.13 ETO11513.1 - 0.032 14.5 0.7 0.037 14.3 0.7 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Connexin PF00029.19 ETO11513.1 - 0.047 13.4 1.4 0.047 13.4 1.4 1.0 1 0 0 1 1 1 0 Connexin DUF3504 PF12012.8 ETO11513.1 - 0.071 13.0 0.8 0.089 12.7 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) DUF2207 PF09972.9 ETO11514.1 - 0.065 12.0 3.7 0.063 12.0 3.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EMC3_TMCO1 PF01956.16 ETO11514.1 - 0.51 10.0 11.0 0.051 13.3 6.8 1.4 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like TraP PF07296.11 ETO11516.1 - 0.077 12.2 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 TraP protein p450 PF00067.22 ETO11517.1 - 8.9e-40 136.8 0.1 2.5e-39 135.3 0.1 1.6 1 1 0 1 1 1 1 Cytochrome P450 DUF1477 PF07346.11 ETO11520.1 - 0.028 14.7 2.7 3.1 8.1 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1477) ERAP1_C PF11838.8 ETO11522.1 - 1.3e-09 38.1 0.4 1.1e-08 35.1 0.1 1.9 2 0 0 2 2 2 1 ERAP1-like C-terminal domain Mer2 PF09074.10 ETO11522.1 - 0.0064 16.3 3.1 0.0073 16.1 3.1 1.1 1 0 0 1 1 1 1 Mer2 NTF2 PF02136.20 ETO11522.1 - 0.058 14.0 0.2 0.21 12.2 0.0 1.8 1 1 1 2 2 2 0 Nuclear transport factor 2 (NTF2) domain DUF4446 PF14584.6 ETO11522.1 - 0.41 10.6 4.9 0.84 9.6 4.5 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) PRANC PF09372.10 ETO11522.1 - 1.6 9.1 9.9 1.6 9.1 5.7 2.3 2 1 1 3 3 3 0 PRANC domain APC_u13 PF16634.5 ETO11523.1 - 0.0035 17.2 0.7 0.01 15.7 0.7 1.8 1 0 0 1 1 1 1 Unstructured region on APC between APC_crr and SAMP Transformer PF06495.11 ETO11523.1 - 0.097 12.8 8.2 0.13 12.3 8.2 1.1 1 0 0 1 1 1 0 Fruit fly transformer protein DUF4614 PF15391.6 ETO11523.1 - 0.17 11.9 12.1 0.2 11.7 12.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) DUF262 PF03235.14 ETO11523.1 - 0.76 9.9 7.8 0.87 9.7 7.8 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 RP-C_C PF11800.8 ETO11523.1 - 1.2 9.2 7.8 1.4 9.0 7.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region TP53IP5 PF15331.6 ETO11523.1 - 2.1 8.4 17.6 2.6 8.2 17.6 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 NPR3 PF03666.13 ETO11523.1 - 2.8 6.6 17.5 3.1 6.5 17.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 ETO11523.1 - 4 5.9 16.9 4.2 5.8 16.9 1.1 1 0 0 1 1 1 0 Macoilin family XRN_M PF17846.1 ETO11523.1 - 7.3 5.4 12.0 10 5.0 12.0 1.1 1 0 0 1 1 1 0 Xrn1 helical domain POX PF07526.11 ETO11524.1 - 0.53 10.9 5.1 1.7 9.2 0.7 2.6 1 1 1 3 3 3 0 Associated with HOX DUF5409 PF17421.2 ETO11525.1 - 0.0029 18.3 0.8 0.0085 16.8 0.8 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5409) SAM_4 PF18017.1 ETO11525.1 - 0.058 13.4 0.1 0.18 11.8 0.1 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PBECR1 PF18809.1 ETO11525.1 - 1.9 9.2 6.9 1.8 9.3 1.1 2.6 2 0 0 2 2 2 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 PHO4 PF01384.20 ETO11526.1 - 0.76 8.8 3.9 0.91 8.5 3.9 1.1 1 0 0 1 1 1 0 Phosphate transporter family PHO4 PF01384.20 ETO11527.1 - 1.2 8.1 3.0 2 7.4 2.5 1.5 1 1 0 1 1 1 0 Phosphate transporter family Promethin PF16015.5 ETO11527.1 - 1.4 8.9 7.3 15 5.5 2.6 2.9 2 0 0 2 2 2 0 Promethin DNA_RNApol_7kD PF03604.13 ETO11528.1 - 2.7e-11 42.9 4.1 5.5e-11 42.0 4.1 1.5 1 0 0 1 1 1 1 DNA directed RNA polymerase, 7 kDa subunit Rad60-SLD PF11976.8 ETO11528.1 - 1.7e-08 34.2 2.3 0.027 14.3 0.0 4.4 4 0 0 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETO11528.1 - 9.1e-08 31.7 4.0 0.019 14.7 0.2 4.3 4 0 0 4 4 4 2 Ubiquitin family Zn_ribbon_SprT PF17283.2 ETO11528.1 - 0.023 14.6 0.5 0.043 13.7 0.5 1.5 1 0 0 1 1 1 0 SprT-like zinc ribbon domain TUG-UBL1 PF11470.8 ETO11528.1 - 0.031 14.5 1.1 2.1 8.6 0.2 2.7 2 0 0 2 2 2 0 TUG ubiquitin-like domain HypA PF01155.19 ETO11528.1 - 0.11 12.6 0.2 0.24 11.4 0.2 1.5 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Ubiquitin_4 PF18036.1 ETO11528.1 - 0.63 10.1 4.6 24 5.0 0.0 4.0 4 0 0 4 4 4 0 Ubiquitin-like domain Kelch_6 PF13964.6 ETO11529.1 - 4.9e-05 23.5 0.8 2.2 8.7 0.0 4.6 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO11529.1 - 0.001 18.6 0.5 0.36 10.5 0.0 3.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO11529.1 - 0.0019 18.2 0.0 0.18 11.8 0.0 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Pkinase PF00069.25 ETO11530.1 - 8.5e-05 22.0 0.1 0.00013 21.4 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ETO11531.1 - 2.5e-07 31.3 7.2 4.2e-06 27.4 0.4 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat W_rich_C PF07483.11 ETO11531.1 - 2.4 8.3 9.6 0.84 9.8 1.1 2.9 1 1 2 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain DnaJ PF00226.31 ETO11532.1 - 0.00014 21.9 0.5 0.00054 20.0 0.1 2.2 2 0 0 2 2 2 1 DnaJ domain Peptidase_C37 PF05416.12 ETO11532.1 - 1.2 7.5 4.8 1.6 7.2 4.8 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase RasGEF PF00617.19 ETO11535.1 - 0.00028 21.2 1.0 0.00077 19.7 1.0 1.7 1 0 0 1 1 1 1 RasGEF domain mRNA_triPase PF02940.15 ETO11536.1 - 4.1e-17 62.7 7.0 2.5e-16 60.1 5.4 2.0 2 0 0 2 2 2 2 mRNA capping enzyme, beta chain Histone PF00125.24 ETO11537.1 - 1.9e-14 54.1 0.4 3.5e-14 53.3 0.4 1.4 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ETO11537.1 - 0.015 15.6 1.0 0.024 14.9 0.1 1.8 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2606 PF10794.9 ETO11537.1 - 0.11 12.3 0.2 0.21 11.4 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) Actin PF00022.19 ETO11538.1 - 4.9e-60 203.3 0.0 5.4e-60 203.1 0.0 1.0 1 0 0 1 1 1 1 Actin TRAPPC-Trs85 PF12739.7 ETO11539.1 - 0.016 14.2 0.4 0.021 13.8 0.4 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Orf78 PF06024.12 ETO11539.1 - 0.029 14.6 0.2 0.05 13.9 0.2 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Spectrin_like PF18373.1 ETO11541.1 - 0.049 13.7 0.0 0.28 11.3 0.0 2.3 1 1 0 1 1 1 0 Spectrin like domain Cytochrom_B562 PF07361.11 ETO11541.1 - 0.059 14.0 0.2 0.22 12.2 0.0 2.1 2 0 0 2 2 2 0 Cytochrome b562 Cep57_MT_bd PF06657.13 ETO11543.1 - 0.05 14.1 2.5 0.14 12.7 2.5 1.8 1 0 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 GTP_EFTU_D2 PF03144.25 ETO11544.1 - 1.5e-05 25.3 0.1 5.9e-05 23.4 0.0 2.0 2 1 0 2 2 2 1 Elongation factor Tu domain 2 DUF2682 PF10909.8 ETO11544.1 - 0.056 13.9 0.1 0.087 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2682) GTP_EFTU_D4 PF14578.6 ETO11544.1 - 0.086 12.8 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu domain 4 Peptidase_C14 PF00656.22 ETO11545.1 - 3.7e-07 30.4 0.3 8.2e-06 25.9 0.3 2.0 1 1 0 1 1 1 1 Caspase domain YHYH PF14240.6 ETO11545.1 - 0.15 12.0 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 YHYH protein WD40 PF00400.32 ETO11546.1 - 3.9e-58 192.1 28.9 5.7e-10 39.6 0.1 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11546.1 - 2e-21 76.1 3.4 5.1e-05 23.5 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11546.1 - 2.1e-15 56.5 1.5 0.032 13.2 0.0 6.1 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11546.1 - 1.1e-07 31.5 0.1 0.025 13.9 0.0 3.2 1 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO11546.1 - 2.6e-07 29.7 0.7 0.53 8.9 0.0 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO11546.1 - 0.00014 22.0 1.3 21 5.2 0.1 4.8 2 2 3 5 5 5 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO11546.1 - 0.0013 18.6 7.1 26 4.9 0.1 6.3 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO11546.1 - 0.0031 17.2 5.3 31 4.4 0.0 5.8 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETO11546.1 - 0.007 14.9 0.5 2.6 6.5 0.0 3.0 2 1 1 3 3 3 1 Cytochrome D1 heme domain Gmad1 PF10647.9 ETO11546.1 - 0.021 14.6 0.1 7 6.3 0.0 2.7 2 1 1 3 3 3 0 Lipoprotein LpqB beta-propeller domain DUF5122 PF17164.4 ETO11546.1 - 0.14 12.4 0.1 42 4.6 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5122) beta-propeller DUF1797 PF08796.10 ETO11546.1 - 0.18 11.9 0.0 38 4.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) Ion_trans PF00520.31 ETO11547.1 - 0.031 13.5 2.9 0.049 12.9 2.9 1.3 1 0 0 1 1 1 0 Ion transport protein WD40 PF00400.32 ETO11548.1 - 3.7e-23 81.4 11.0 0.0017 19.1 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO11548.1 - 1.2e-06 27.5 0.3 0.017 13.8 0.1 3.2 3 1 0 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11548.1 - 1.1e-05 25.6 0.2 4.9 7.5 0.0 4.4 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO11548.1 - 0.0016 18.4 0.3 0.7 9.7 0.1 3.1 2 2 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A YniB PF14002.6 ETO11549.1 - 0.0014 18.4 1.0 0.0029 17.4 1.0 1.5 1 0 0 1 1 1 1 YniB-like protein U79_P34 PF03064.16 ETO11549.1 - 0.47 9.8 14.0 0.64 9.3 14.0 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 MAP17 PF15807.5 ETO11549.1 - 2.7 8.2 7.4 5.3 7.3 7.4 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 F-actin_cap_A PF01267.17 ETO11551.1 - 2.4e-43 148.5 0.6 2.2e-33 115.9 0.0 2.7 2 1 0 2 2 2 2 F-actin capping protein alpha subunit DUF2389 PF09493.10 ETO11551.1 - 0.052 14.2 1.6 12 6.6 0.0 3.8 4 0 0 4 4 4 0 Tryptophan-rich protein (DUF2389) MORN_2 PF07661.13 ETO11551.1 - 0.098 12.9 1.9 24 5.6 0.2 4.0 3 1 1 4 4 4 0 MORN repeat variant Rad50_zn_hook PF04423.14 ETO11551.1 - 1.3 8.9 3.7 18 5.2 0.1 2.9 3 0 0 3 3 3 0 Rad50 zinc hook motif TPR_MLP1_2 PF07926.12 ETO11552.1 - 0.0002 21.4 20.5 0.0002 21.4 20.5 4.4 2 2 2 4 4 4 2 TPR/MLP1/MLP2-like protein Herpes_BLRF2 PF05812.12 ETO11552.1 - 0.0022 18.1 20.6 0.24 11.5 2.7 3.7 1 1 1 2 2 2 2 Herpesvirus BLRF2 protein Fez1 PF06818.15 ETO11552.1 - 0.36 11.3 53.2 2 8.8 19.7 3.1 1 1 2 3 3 3 0 Fez1 FAM184 PF15665.5 ETO11552.1 - 0.45 10.3 42.5 0.16 11.8 32.2 2.2 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Spc7 PF08317.11 ETO11552.1 - 0.57 9.0 54.6 0.026 13.4 31.7 2.5 1 1 1 2 2 2 0 Spc7 kinetochore protein HMMR_N PF15905.5 ETO11552.1 - 0.83 9.1 60.3 1.2 8.5 35.2 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Zea_mays_MuDR PF05928.11 ETO11554.1 - 0.016 14.9 1.3 0.018 14.7 1.3 1.1 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) DUF1054 PF06335.12 ETO11554.1 - 0.25 11.2 5.1 0.31 11.0 5.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) IF-2B PF01008.17 ETO11554.1 - 0.44 9.7 6.8 0.49 9.5 6.8 1.1 1 0 0 1 1 1 0 Initiation factor 2 subunit family ABC2_membrane_3 PF12698.7 ETO11554.1 - 3 6.8 11.0 3.6 6.6 11.0 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Goodbye PF17109.5 ETO11554.1 - 5.2 7.6 8.4 2.2 8.8 1.7 2.1 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain Endostatin PF06482.11 ETO11555.1 - 0.024 14.1 10.8 0.029 13.9 10.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 ETO11555.1 - 0.081 11.7 14.5 0.097 11.4 14.5 1.1 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 ETO11555.1 - 0.14 10.9 11.8 0.15 10.8 11.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Hid1 PF12722.7 ETO11555.1 - 0.16 10.0 12.2 0.17 10.0 12.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 ETO11555.1 - 0.23 9.8 4.5 0.28 9.5 4.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 ETO11555.1 - 0.33 10.1 10.4 0.45 9.7 10.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Dsh_C PF12316.8 ETO11555.1 - 1 9.7 5.1 1.3 9.4 5.1 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal MDM10 PF12519.8 ETO11555.1 - 1.9 7.2 13.5 2.1 7.1 13.5 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Neur_chan_memb PF02932.16 ETO11555.1 - 2.7 8.0 14.0 2.9 7.9 14.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4569 PF15133.6 ETO11555.1 - 2.8 7.6 15.0 3.5 7.3 15.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Mem_trans PF03547.18 ETO11555.1 - 3.2 6.0 4.0 3.5 5.9 4.0 1.2 1 0 0 1 1 1 0 Membrane transport protein Serinc PF03348.15 ETO11555.1 - 3.4 6.5 4.2 4.2 6.2 4.2 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) SLC12 PF03522.15 ETO11555.1 - 5.9 5.8 20.3 6.9 5.6 20.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 ETO11555.1 - 6.7 5.4 23.1 8 5.1 23.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CUE PF02845.16 ETO11556.1 - 0.028 14.1 0.7 5.6 6.8 0.0 2.8 3 0 0 3 3 3 0 CUE domain Guanylate_cyc PF00211.20 ETO11557.1 - 0.0012 18.5 0.0 0.0025 17.4 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain AC_N PF16214.5 ETO11557.1 - 0.062 12.4 0.5 0.083 12.0 0.5 1.3 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF373 PF04123.13 ETO11557.1 - 0.15 11.5 1.4 0.21 11.0 1.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF373) PX PF00787.24 ETO11558.1 - 0.0082 16.1 1.2 0.012 15.6 1.2 1.5 1 1 0 1 1 1 1 PX domain Imm41 PF15592.6 ETO11558.1 - 0.014 15.8 2.5 0.02 15.2 2.4 1.4 1 1 0 1 1 1 0 Immunity protein 41 Mito_carr PF00153.27 ETO11560.1 - 3.8e-12 45.9 1.2 7.1e-12 45.1 1.2 1.4 1 0 0 1 1 1 1 Mitochondrial carrier protein Tropomyosin_1 PF12718.7 ETO11561.1 - 3e-05 24.2 11.4 3e-05 24.2 11.4 3.2 3 1 0 3 3 3 1 Tropomyosin like Laminin_II PF06009.12 ETO11561.1 - 0.012 15.7 3.7 0.012 15.7 3.7 3.3 3 0 0 3 3 3 0 Laminin Domain II DUF745 PF05335.13 ETO11561.1 - 0.72 9.5 15.6 0.07 12.8 4.2 3.6 3 0 0 3 3 3 0 Protein of unknown function (DUF745) PhageMin_Tail PF10145.9 ETO11561.1 - 1.8 8.4 6.2 2.9 7.7 1.2 2.6 2 0 0 2 2 2 0 Phage-related minor tail protein DUF948 PF06103.11 ETO11561.1 - 3 8.2 6.5 15 5.9 0.8 3.7 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) KH_2 PF07650.17 ETO11561.1 - 3 7.7 13.5 0.17 11.7 3.4 3.1 3 0 0 3 3 3 0 KH domain ASL_C PF08328.11 ETO11561.1 - 5.2 7.2 7.5 0.63 10.2 1.2 2.8 2 1 1 3 3 3 0 Adenylosuccinate lyase C-terminal DUF3782 PF12644.7 ETO11561.1 - 5.5 7.2 9.8 2.1 8.5 0.5 3.7 3 2 0 3 3 3 0 Protein of unknown function (DUF3782) Nup54 PF13874.6 ETO11564.1 - 0.0033 17.5 13.3 0.044 13.9 0.4 2.7 2 0 0 2 2 2 2 Nucleoporin complex subunit 54 DUF948 PF06103.11 ETO11564.1 - 0.77 10.1 7.4 1.5 9.1 2.6 3.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TEX13 PF15186.6 ETO11564.1 - 1.5 8.5 11.6 0.79 9.4 3.3 3.2 3 0 0 3 3 3 0 Testis-expressed sequence 13 protein family HetR_C PF18460.1 ETO11565.1 - 0.022 14.7 1.0 0.09 12.7 0.2 2.1 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain Med6 PF04934.14 ETO11566.1 - 0.005 16.6 0.5 0.005 16.6 0.5 1.8 2 0 0 2 2 2 1 MED6 mediator sub complex component RNase_H PF00075.24 ETO11567.1 - 5.7e-14 52.5 3.4 1.6e-13 51.1 0.2 2.9 2 1 0 2 2 2 1 RNase H Wound_ind PF08186.11 ETO11568.1 - 0.0043 17.4 0.6 0.0085 16.5 0.6 1.5 1 0 0 1 1 1 1 Wound-inducible basic protein family OKR_DC_1_C PF03711.15 ETO11568.1 - 0.078 13.3 0.3 0.12 12.7 0.3 1.3 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, C-terminal domain RVT_1 PF00078.27 ETO11569.1 - 2e-27 96.1 0.2 3.5e-27 95.4 0.2 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF240 PF03086.14 ETO11569.1 - 0.12 12.3 0.3 0.66 9.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF240) SPATIAL PF15256.6 ETO11570.1 - 0.02 15.2 4.7 0.021 15.2 4.7 1.1 1 0 0 1 1 1 0 SPATIAL Raptor_N PF14538.6 ETO11570.1 - 0.095 12.7 0.3 0.11 12.4 0.3 1.2 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain Vfa1 PF08432.10 ETO11570.1 - 0.57 10.5 15.3 0.62 10.4 15.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 LRIF1 PF15741.5 ETO11570.1 - 1.5 7.2 12.4 1.6 7.2 12.4 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 MCM_bind PF09739.9 ETO11570.1 - 2.3 6.6 11.7 2.5 6.4 11.7 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor kleA_kleC PF17383.2 ETO11572.1 - 0.039 14.3 0.3 0.08 13.3 0.3 1.5 1 0 0 1 1 1 0 Uncharacterized KorC regulated protein A DUF1539 PF07560.11 ETO11572.1 - 0.043 13.9 1.3 4 7.5 0.1 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) Glyco_transf_90 PF05686.12 ETO11573.1 - 3.3e-28 98.7 0.9 9e-28 97.3 0.9 1.5 1 1 0 1 1 1 1 Glycosyl transferase family 90 Glyco_trans_1_2 PF13524.6 ETO11573.1 - 0.00019 21.7 0.0 0.0004 20.7 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Rep_3 PF01051.21 ETO11575.1 - 0.0057 16.5 0.2 0.0057 16.5 0.2 2.4 2 1 0 2 2 2 1 Initiator Replication protein Menin PF05053.13 ETO11577.1 - 0.61 8.4 6.3 0.88 7.8 6.3 1.1 1 0 0 1 1 1 0 Menin Cbl_N2 PF02761.14 ETO11577.1 - 9.6 7.0 7.5 2.8 8.7 0.5 3.4 4 1 1 5 5 5 0 CBL proto-oncogene N-terminus, EF hand-like domain WD40 PF00400.32 ETO11579.1 - 7.4e-29 99.4 2.5 4e-08 33.8 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11579.1 - 9.1e-13 48.3 0.2 0.0019 18.5 0.1 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11579.1 - 7.1e-06 25.6 0.1 0.00016 21.1 0.1 2.0 1 1 1 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO11579.1 - 8.3e-06 24.7 1.1 0.0032 16.2 0.1 2.9 1 1 2 3 3 3 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO11579.1 - 2.3e-05 23.5 0.0 0.56 9.1 0.0 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO11579.1 - 5.4e-05 23.1 0.4 8.6e-05 22.5 0.4 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A Utp8 PF10395.9 ETO11579.1 - 0.0028 16.3 0.1 0.26 9.7 0.0 2.0 1 1 1 2 2 2 2 Utp8 family PALB2_WD40 PF16756.5 ETO11579.1 - 0.0034 16.4 0.6 0.18 10.7 0.1 2.4 1 1 1 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 ETO11579.1 - 0.0056 15.5 0.2 1.2 7.8 0.0 2.2 1 1 1 2 2 2 2 Nup133 N terminal like Syd PF07348.12 ETO11579.1 - 0.0072 16.0 0.0 0.0091 15.7 0.0 1.1 1 0 0 1 1 1 1 Syd protein (SUKH-2) Cytochrom_D1 PF02239.16 ETO11579.1 - 0.008 14.7 0.0 0.45 9.0 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO11579.1 - 0.01 15.7 2.2 2.6 8.1 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO11579.1 - 0.043 13.9 0.8 0.8 9.8 0.1 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5474) DUF4999 PF16390.5 ETO11579.1 - 0.65 10.3 2.4 12 6.2 0.1 2.9 2 1 1 3 3 3 0 Domain of unknown function DUF2149 PF09919.9 ETO11580.1 - 9.6 6.5 10.6 2.2 8.6 7.2 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2149) MBOAT PF03062.19 ETO11581.1 - 2.6e-06 27.1 31.0 4.6e-05 22.9 19.9 3.2 2 1 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family Actin PF00022.19 ETO11582.1 - 5.3e-109 364.5 0.0 2.1e-108 362.6 0.0 1.7 1 1 0 1 1 1 1 Actin GerD PF17898.1 ETO11582.1 - 0.056 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain SGS PF05002.15 ETO11582.1 - 0.16 12.1 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 SGS domain BPL_LplA_LipB PF03099.19 ETO11584.1 - 5.2e-18 65.2 0.1 1.1e-17 64.2 0.1 1.5 1 0 0 1 1 1 1 Biotin/lipoate A/B protein ligase family U1snRNP70_N PF12220.8 ETO11584.1 - 0.29 11.8 3.0 0.54 10.9 3.0 1.4 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PAP2_C PF14360.6 ETO11585.1 - 0.0087 16.6 0.1 0.013 16.0 0.1 1.2 1 0 0 1 1 1 1 PAP2 superfamily C-terminal RyR PF02026.16 ETO11586.1 - 2.2e-08 34.2 0.0 6.4e-07 29.5 0.0 2.1 2 0 0 2 2 2 2 RyR domain Ank_3 PF13606.6 ETO11587.1 - 1.2e-08 34.5 1.4 0.00068 19.9 0.0 3.7 5 0 0 5 5 5 2 Ankyrin repeat Ank_5 PF13857.6 ETO11587.1 - 1e-07 32.0 0.4 2.3e-05 24.6 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO11587.1 - 3.5e-07 30.6 0.4 1.9e-06 28.3 0.2 2.5 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO11587.1 - 8.8e-07 29.4 0.1 9.3e-06 26.2 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO11587.1 - 2.4e-05 24.5 0.1 0.02 15.3 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Menin PF05053.13 ETO11588.1 - 0.058 11.8 0.0 0.075 11.4 0.0 1.1 1 0 0 1 1 1 0 Menin DUF2175 PF09943.9 ETO11590.1 - 0.66 10.3 4.8 3.8 7.9 4.8 2.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) SAM_1 PF00536.30 ETO11591.1 - 0.0012 19.2 0.4 0.0042 17.5 0.2 2.0 2 1 1 3 3 3 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO11591.1 - 0.044 13.9 0.1 0.088 12.9 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ANAPC4_WD40 PF12894.7 ETO11594.1 - 0.0062 16.8 0.2 0.3 11.4 0.0 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO11594.1 - 0.035 15.0 0.0 1.3 10.0 0.0 2.5 2 0 0 2 2 2 0 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO11594.1 - 0.071 13.2 0.1 8.6 6.5 0.0 2.3 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region LigT_PEase PF02834.16 ETO11596.1 - 1e-06 28.8 0.2 4e-05 23.7 0.0 2.3 2 0 0 2 2 2 2 LigT like Phosphoesterase FMO-like PF00743.19 ETO11597.1 - 1.1e-07 30.7 0.0 1.7e-07 30.1 0.0 1.2 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Zn_ribbon_17 PF17120.5 ETO11597.1 - 0.026 14.2 0.3 0.053 13.1 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Pyr_redox_3 PF13738.6 ETO11597.1 - 0.11 11.7 0.0 0.21 10.8 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase DUF1684 PF07920.11 ETO11598.1 - 0.024 14.9 0.2 0.052 13.8 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1684) zf-TRAF PF02176.18 ETO11600.1 - 2.2e-06 28.2 2.7 2.2e-06 28.2 2.7 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger DUF723 PF05265.13 ETO11600.1 - 0.073 13.0 4.7 2.2 8.3 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF723) Redoxin PF08534.10 ETO11600.1 - 0.083 12.6 0.6 4.2 7.1 0.1 2.2 1 1 1 2 2 2 0 Redoxin FAM76 PF16046.5 ETO11600.1 - 0.099 12.0 12.6 0.029 13.7 9.6 1.7 2 0 0 2 2 2 0 FAM76 protein LMBR1 PF04791.16 ETO11600.1 - 0.34 9.8 2.4 0.35 9.7 2.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C3HC4_4 PF15227.6 ETO11600.1 - 0.41 10.8 4.9 0.26 11.5 0.9 2.8 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING zf-RING-like PF08746.11 ETO11600.1 - 0.58 10.5 4.8 2.1 8.7 0.0 3.1 2 1 1 3 3 3 0 RING-like domain RseA_C PF03873.13 ETO11600.1 - 1.6 9.0 4.2 5.5 7.3 4.2 1.9 1 0 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain WD40 PF00400.32 ETO11601.1 - 1.7e-99 322.9 41.0 5.9e-09 36.4 0.1 12.4 12 0 0 12 12 12 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11601.1 - 1.7e-23 82.7 10.0 0.0091 16.3 0.0 10.1 1 1 10 11 11 11 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11601.1 - 5.9e-14 52.1 18.3 7.7e-05 22.2 0.1 6.7 2 2 6 8 8 8 6 WD40-like domain Pentapeptide PF00805.22 ETO11601.1 - 3.2e-08 33.0 1.0 7.5e-08 31.9 1.0 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO11601.1 - 1.7e-05 24.9 0.6 7e-05 22.9 0.2 2.2 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO11601.1 - 2e-05 23.3 7.0 0.92 8.0 0.0 5.0 3 2 2 5 5 5 3 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO11601.1 - 0.00075 19.6 0.3 0.0023 18.0 0.3 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF4072 PF13284.6 ETO11601.1 - 0.0022 18.4 0.0 41 4.7 0.0 5.8 8 0 0 8 8 7 0 Domain of unknown function (DUF4072) Pneumo_M2 PF07380.11 ETO11601.1 - 0.029 14.6 2.9 1.7 9.0 0.2 2.8 2 0 0 2 2 2 0 Pneumovirus M2 protein PD40 PF07676.12 ETO11601.1 - 0.094 12.7 3.3 29 4.7 0.0 5.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PRP1_N PF06424.12 ETO11601.1 - 0.16 12.4 0.3 0.33 11.4 0.3 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal YqaJ PF09588.10 ETO11601.1 - 0.17 12.1 0.6 15 5.7 0.1 3.3 2 1 0 2 2 2 0 YqaJ-like viral recombinase domain TbpB_A PF17484.2 ETO11601.1 - 0.23 12.2 1.1 0.53 11.0 1.1 1.6 1 0 0 1 1 1 0 N-Lobe handle Tf-binding protein B NACHT PF05729.12 ETO11602.1 - 5.1e-10 39.5 0.0 1e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO11602.1 - 0.00015 22.1 0.2 0.0011 19.3 0.1 2.6 2 2 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO11602.1 - 0.0021 18.6 1.9 0.0034 17.9 0.1 2.3 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 ETO11602.1 - 0.014 15.4 0.0 0.1 12.6 0.0 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATP_bind_2 PF03668.15 ETO11602.1 - 0.014 14.7 0.1 0.034 13.4 0.0 1.7 2 0 0 2 2 2 0 P-loop ATPase protein family AAA PF00004.29 ETO11602.1 - 0.039 14.4 0.0 0.1 13.0 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO11602.1 - 0.052 13.9 0.1 0.56 10.6 0.1 2.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ETO11602.1 - 0.063 13.4 0.0 0.16 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO11602.1 - 0.064 13.7 1.4 0.48 10.8 0.0 2.6 1 1 1 2 2 2 0 RNA helicase RsgA_GTPase PF03193.16 ETO11602.1 - 0.075 12.9 0.7 0.38 10.6 0.1 2.4 2 1 0 3 3 3 0 RsgA GTPase ATPase PF06745.13 ETO11602.1 - 0.079 12.3 1.1 2.1 7.7 0.0 2.8 3 0 0 3 3 3 0 KaiC AAA_5 PF07728.14 ETO11602.1 - 0.086 12.8 0.0 0.27 11.2 0.0 2.0 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO11602.1 - 0.1 13.1 0.3 0.37 11.3 0.3 2.0 1 1 0 1 1 1 0 ABC transporter F-box-like PF12937.7 ETO11604.1 - 1.3e-07 31.4 0.4 1.3e-06 28.2 0.1 2.2 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ETO11604.1 - 2.4e-06 27.3 0.0 1.7e-05 24.6 0.0 2.4 2 1 1 3 3 3 1 F-box domain Utp14 PF04615.13 ETO11604.1 - 0.026 13.1 14.7 0.034 12.7 14.7 1.1 1 0 0 1 1 1 0 Utp14 protein DUF1168 PF06658.12 ETO11604.1 - 0.49 10.2 14.2 1.7 8.5 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) Ank_2 PF12796.7 ETO11605.1 - 8.4e-10 39.1 0.9 2.5e-09 37.6 0.3 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO11605.1 - 4.4e-08 33.5 0.1 4.4e-06 27.1 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO11605.1 - 6.9e-08 32.6 0.0 0.00024 21.4 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO11605.1 - 8.7e-06 25.7 0.1 0.18 12.4 0.0 4.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETO11605.1 - 0.0015 18.9 0.1 2 9.0 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Arm PF00514.23 ETO11605.1 - 0.028 14.4 6.9 0.034 14.2 0.1 3.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat Peptidase_S49 PF01343.18 ETO11606.1 - 6.4e-12 45.7 0.0 9.8e-12 45.1 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S49 Poly_export PF02563.16 ETO11606.1 - 0.12 12.6 0.0 0.26 11.5 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis/export protein FadA PF09403.10 ETO11606.1 - 0.18 12.3 1.7 0.89 10.1 0.1 2.5 3 0 0 3 3 3 0 Adhesion protein FadA BAR_3_WASP_bdg PF10456.9 ETO11607.1 - 0.027 13.9 0.3 0.04 13.4 0.2 1.4 1 1 1 2 2 2 0 WASP-binding domain of Sorting nexin protein Ribosomal_L27A PF00828.19 ETO11607.1 - 0.03 15.0 1.3 0.037 14.7 1.3 1.2 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A CLASP_N PF12348.8 ETO11608.1 - 2.9e-06 27.0 3.8 0.0034 17.0 0.9 2.5 2 0 0 2 2 2 2 CLASP N terminal Cnd1 PF12717.7 ETO11608.1 - 0.011 15.8 0.7 12 5.9 0.0 3.5 2 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 FBPase_2 PF06874.11 ETO11609.1 - 0.14 10.4 0.4 2.9 6.1 0.0 2.0 2 0 0 2 2 2 0 Firmicute fructose-1,6-bisphosphatase Sigma70_ner PF04546.13 ETO11610.1 - 0.0024 17.8 2.1 0.0024 17.8 2.1 1.7 2 0 0 2 2 2 1 Sigma-70, non-essential region DUF2151 PF10221.9 ETO11610.1 - 0.011 14.4 3.9 0.013 14.2 3.9 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator RRN3 PF05327.11 ETO11610.1 - 0.014 14.0 3.6 0.017 13.7 3.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CCDC106 PF15794.5 ETO11610.1 - 0.018 14.8 1.2 0.018 14.8 1.2 1.6 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 SDA1 PF05285.12 ETO11610.1 - 0.12 11.8 15.6 0.045 13.2 10.7 1.9 2 0 0 2 2 2 0 SDA1 CPSF100_C PF13299.6 ETO11610.1 - 1.1 9.4 5.2 2.1 8.5 5.2 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 ETO11610.1 - 1.6 7.4 3.7 2.2 7.0 3.7 1.2 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 ETO11610.1 - 8.4 5.8 10.1 1.4 8.4 6.2 1.6 2 0 0 2 2 2 0 Translocation protein Sec62 SNARE PF05739.19 ETO11611.1 - 2.3e-07 30.7 0.2 2.3e-07 30.7 0.2 3.5 3 0 0 3 3 3 1 SNARE domain Apolipoprotein PF01442.18 ETO11611.1 - 0.059 13.2 9.9 0.12 12.3 2.7 2.4 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain Cwf_Cwc_15 PF04889.12 ETO11611.1 - 0.42 10.3 27.9 1 9.1 27.9 1.6 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF1043 PF06295.12 ETO11611.1 - 6.5 6.8 17.1 0.035 14.1 1.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) Kinetochor_Ybp2 PF08568.10 ETO11612.1 - 2.5e-05 23.0 4.2 4.2e-05 22.2 4.1 1.5 1 1 0 1 1 1 1 Uncharacterised protein family, YAP/Alf4/glomulin WD40 PF00400.32 ETO11613.1 - 1.3e-18 67.0 5.9 4.6e-06 27.3 0.1 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11613.1 - 4.5e-05 23.7 0.2 2 8.8 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11613.1 - 0.0029 16.3 0.4 0.78 8.3 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF2509 PF10713.9 ETO11613.1 - 0.12 12.4 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2509) AAA_16 PF13191.6 ETO11614.1 - 0.0058 17.0 0.0 0.015 15.7 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO11614.1 - 0.074 13.4 7.1 0.37 11.2 0.0 4.6 5 0 0 5 5 5 0 RNA helicase AAA_22 PF13401.6 ETO11614.1 - 0.075 13.3 3.9 0.38 11.0 0.2 3.7 4 1 0 4 4 4 0 AAA domain AAA_29 PF13555.6 ETO11614.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF87 PF01935.17 ETO11614.1 - 0.12 12.5 0.0 0.12 12.5 0.0 3.5 3 2 0 3 3 3 0 Helicase HerA, central domain AAA_16 PF13191.6 ETO11615.1 - 0.00013 22.4 0.0 0.00026 21.4 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_24 PF13479.6 ETO11615.1 - 0.00019 21.2 0.7 0.66 9.7 0.0 2.8 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ETO11615.1 - 0.0033 17.7 2.8 0.019 15.2 0.4 3.0 3 2 0 3 3 3 1 AAA domain AAA_29 PF13555.6 ETO11615.1 - 0.022 14.5 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ETO11615.1 - 0.085 13.2 4.5 0.33 11.3 0.0 3.9 2 2 0 3 3 3 0 RNA helicase C4 PF01413.19 ETO11615.1 - 0.12 12.8 0.4 9 6.7 0.1 2.6 2 0 0 2 2 2 0 C-terminal tandem repeated domain in type 4 procollagen PB1 PF00564.24 ETO11615.1 - 0.16 11.9 2.8 0.2 11.6 0.1 2.6 3 1 0 3 3 3 0 PB1 domain DUF87 PF01935.17 ETO11615.1 - 0.18 11.8 0.0 0.18 11.8 0.0 3.3 2 2 1 3 3 2 0 Helicase HerA, central domain RsgA_GTPase PF03193.16 ETO11615.1 - 0.53 10.2 0.0 0.53 10.2 0.0 2.6 2 1 0 3 3 3 0 RsgA GTPase WSD PF15613.6 ETO11615.1 - 1 9.9 4.9 1.5 9.4 0.2 2.7 2 1 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif eIF3_p135 PF12807.7 ETO11615.1 - 1.4 9.0 8.8 0.31 11.0 0.8 2.4 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Pre-PUA PF17832.1 ETO11615.1 - 5.4 7.8 9.5 3.2 8.5 5.7 2.4 2 0 0 2 2 2 0 Pre-PUA-like domain Mac PF12464.8 ETO11616.1 - 0.028 14.6 1.8 0.028 14.6 1.8 3.0 2 1 1 3 3 3 0 Maltose acetyltransferase DUF4888 PF16229.5 ETO11616.1 - 0.037 14.0 0.4 0.063 13.2 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4888) DUF572 PF04502.13 ETO11616.1 - 0.086 12.4 24.9 0.015 14.9 14.8 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) FUSC PF04632.12 ETO11616.1 - 0.14 10.6 3.0 0.2 10.2 3.0 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family FliE PF02049.18 ETO11616.1 - 2.4 8.4 7.1 3.6 7.8 0.2 3.1 2 1 0 2 2 2 0 Flagellar hook-basal body complex protein FliE DUF1908 PF08926.11 ETO11616.1 - 4.1 6.4 9.4 0.21 10.6 1.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1908) DUF3734 PF12536.8 ETO11616.1 - 5.3 7.4 10.2 1.4 9.3 0.7 2.8 2 1 1 3 3 3 0 Patatin phospholipase Sec6 PF06046.13 ETO11617.1 - 6.3e-17 61.2 7.3 3.4e-12 45.6 0.1 2.7 2 1 0 2 2 2 2 Exocyst complex component Sec6 DUF445 PF04286.12 ETO11617.1 - 0.013 15.3 0.0 0.025 14.4 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF445) Noelin-1 PF12308.8 ETO11617.1 - 0.039 13.9 2.8 4.7 7.3 0.3 3.3 2 2 1 3 3 3 0 Neurogenesis glycoprotein TAN PF11640.8 ETO11617.1 - 0.12 12.5 0.8 2.8 8.0 0.2 2.3 2 0 0 2 2 2 0 Telomere-length maintenance and DNA damage repair G-gamma PF00631.22 ETO11618.1 - 0.28 11.2 5.1 0.27 11.3 0.7 2.7 2 0 0 2 2 2 0 GGL domain Kelch_6 PF13964.6 ETO11619.1 - 0.033 14.5 1.7 0.26 11.6 0.2 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO11619.1 - 0.037 13.6 0.1 0.26 10.9 0.0 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO11619.1 - 0.099 13.0 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain EnY2 PF10163.9 ETO11621.1 - 0.12 12.7 2.7 0.18 12.2 0.6 2.2 1 1 1 2 2 2 0 Transcription factor e(y)2 Tetraspanin PF00335.20 ETO11622.1 - 4.9e-19 69.0 15.1 6.4e-19 68.6 15.1 1.2 1 0 0 1 1 1 1 Tetraspanin family DUF365 PF04033.12 ETO11623.1 - 0.11 12.8 0.2 0.13 12.5 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF365) Peptidase_S46 PF10459.9 ETO11624.1 - 0.047 12.3 5.3 0.046 12.4 5.3 1.0 1 0 0 1 1 1 0 Peptidase S46 UBN_AB PF14075.6 ETO11625.1 - 0.0068 16.2 3.6 0.0075 16.0 3.6 1.1 1 0 0 1 1 1 1 Ubinuclein conserved middle domain UCH PF00443.29 ETO11627.1 - 5.8e-18 65.3 9.6 6e-18 65.3 7.4 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4508 PF14969.6 ETO11627.1 - 0.015 15.5 0.3 0.049 13.9 0.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4508) UCH PF00443.29 ETO11628.1 - 2.2e-29 102.8 0.0 2.2e-29 102.8 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO11628.1 - 1.1e-07 31.7 1.6 0.0022 17.6 0.1 2.5 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PHD_Oberon PF07227.11 ETO11628.1 - 0.0084 16.0 0.2 0.02 14.8 0.2 1.6 1 0 0 1 1 1 1 PHD - plant homeodomain finger protein Tudor-knot PF11717.8 ETO11628.1 - 0.018 14.9 4.9 0.44 10.5 0.8 3.3 3 0 0 3 3 3 0 RNA binding activity-knot of a chromodomain MBT PF02820.18 ETO11628.1 - 0.034 14.5 0.1 0.085 13.2 0.1 1.6 1 0 0 1 1 1 0 mbt repeat CENP-B_dimeris PF09026.10 ETO11628.1 - 0.2 12.1 7.1 0.7 10.3 7.1 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 ETO11628.1 - 2 8.7 7.6 8.6 6.7 6.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ETO11628.1 - 2.1 8.0 8.6 6.2 6.5 5.8 2.3 2 0 0 2 2 2 0 FAM176 family MPP6 PF10175.9 ETO11628.1 - 2.2 8.8 7.9 0.22 12.0 2.1 2.1 2 0 0 2 2 2 0 M-phase phosphoprotein 6 NOA36 PF06524.12 ETO11628.1 - 5.3 6.3 7.7 0.93 8.8 3.3 1.8 2 0 0 2 2 2 0 NOA36 protein WD40 PF00400.32 ETO11630.1 - 1.1e-11 45.0 0.4 5.9e-06 26.9 0.1 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11630.1 - 0.013 15.8 0.0 0.08 13.3 0.0 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4248 PF14053.6 ETO11630.1 - 0.11 12.5 0.2 4 7.5 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4248) WW PF00397.26 ETO11631.1 - 7.5e-27 93.1 17.8 6.4e-07 29.4 2.2 4.6 4 0 0 4 4 4 4 WW domain KptA_kDCL PF18176.1 ETO11631.1 - 0.14 12.0 2.3 0.25 11.2 2.3 1.4 1 0 0 1 1 1 0 KptA in kinetoplastid DICER domain Mitofilin PF09731.9 ETO11631.1 - 2.3 7.0 17.4 4.1 6.1 17.4 1.4 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 ETO11631.1 - 3.2 6.2 15.2 4.2 5.8 15.2 1.1 1 0 0 1 1 1 0 Macoilin family WD40 PF00400.32 ETO11632.1 - 2.3e-29 101.0 24.1 1.3e-06 29.1 0.4 7.4 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11632.1 - 6e-08 32.9 0.5 1.2 9.5 0.0 5.1 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO11632.1 - 3.5e-05 24.4 2.7 3.5e-05 24.4 2.7 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger Nup160 PF11715.8 ETO11632.1 - 0.00012 21.0 2.3 0.64 8.6 0.1 4.0 1 1 0 4 4 4 2 Nucleoporin Nup120/160 DUF1664 PF07889.12 ETO11632.1 - 0.0018 18.3 1.0 0.0038 17.3 0.7 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1664) DDE_Tnp_2 PF04693.12 ETO11632.1 - 0.011 15.0 0.5 0.019 14.2 0.5 1.2 1 0 0 1 1 1 0 Archaeal putative transposase ISC1217 Laminin_I PF06008.14 ETO11632.1 - 0.063 13.0 6.7 0.075 12.7 5.4 1.7 1 1 1 2 2 2 0 Laminin Domain I DUF4315 PF14193.6 ETO11632.1 - 0.16 12.0 2.8 0.12 12.4 0.9 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) DUF3498 PF12004.8 ETO11632.1 - 2.8 7.0 4.6 3.9 6.6 4.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3498) TPR_12 PF13424.6 ETO11633.1 - 1.6e-14 53.9 0.1 5.9e-12 45.7 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11633.1 - 1.1e-10 41.0 0.0 2e-06 27.5 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11633.1 - 1e-09 37.8 6.1 0.00026 20.7 1.3 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11633.1 - 3.4e-09 36.1 1.9 0.00015 21.6 1.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11633.1 - 1.3e-06 28.1 5.8 0.0013 18.8 0.3 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11633.1 - 0.00023 21.3 1.1 0.13 12.7 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11633.1 - 0.00096 19.0 0.4 0.24 11.5 0.1 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO11633.1 - 0.011 15.6 0.7 0.43 10.4 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5113) SNAP PF14938.6 ETO11633.1 - 0.013 14.9 0.2 0.022 14.2 0.2 1.3 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_21 PF09976.9 ETO11633.1 - 0.019 14.7 0.1 0.045 13.5 0.1 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 ETO11633.1 - 0.043 13.2 0.0 0.049 13.0 0.0 1.1 1 0 0 1 1 1 0 MalT-like TPR region DUF1917 PF08939.10 ETO11633.1 - 0.052 13.5 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1917) TPR_16 PF13432.6 ETO11633.1 - 0.062 14.0 0.0 0.39 11.4 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat HDV_ag PF01517.18 ETO11633.1 - 0.1 12.4 0.1 0.11 12.3 0.1 1.2 1 0 0 1 1 1 0 Hepatitis delta virus delta antigen WD40 PF00400.32 ETO11634.1 - 4.2e-40 135.0 10.8 1.2e-08 35.5 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11634.1 - 2.1e-12 47.2 3.2 0.036 14.4 0.1 5.2 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11634.1 - 2.2e-08 33.4 0.2 0.15 11.0 0.1 4.6 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO11634.1 - 9.1e-06 24.6 10.8 2.2 6.8 0.1 5.8 1 1 4 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO11634.1 - 7.3e-05 22.6 4.4 3.3 7.7 0.1 4.9 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF3475 PF11961.8 ETO11634.1 - 0.00035 20.6 0.1 0.22 11.6 0.0 3.6 4 1 0 4 4 4 1 Domain of unknown function (DUF3475) DPPIV_N PF00930.21 ETO11634.1 - 0.037 12.8 0.5 0.65 8.7 0.1 3.0 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region WD40 PF00400.32 ETO11635.1 - 6.3e-67 219.9 25.3 8e-08 32.8 0.1 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11635.1 - 1.2e-16 60.8 4.7 0.0024 18.1 0.1 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11635.1 - 4.8e-12 45.8 8.1 0.00011 21.6 2.5 4.5 2 1 2 4 4 4 3 WD40-like domain NACHT PF05729.12 ETO11635.1 - 8.5e-10 38.8 0.0 1.8e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO11635.1 - 1.6e-06 27.6 4.3 3.3e-06 26.6 4.3 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO11635.1 - 2.6e-05 24.3 0.3 8.4e-05 22.7 0.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO11635.1 - 8.9e-05 22.8 0.1 0.00051 20.3 0.1 2.4 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 ETO11635.1 - 0.0014 18.6 0.2 0.0083 16.1 0.0 2.3 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pentapeptide_3 PF13576.6 ETO11635.1 - 0.0036 17.4 0.3 0.0087 16.2 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO11635.1 - 0.0095 16.5 3.5 0.011 16.3 0.0 3.0 3 0 0 3 3 3 1 AAA domain Nbas_N PF15492.6 ETO11635.1 - 0.015 14.6 0.6 5.6 6.2 0.0 3.3 3 1 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal RNA_helicase PF00910.22 ETO11635.1 - 0.019 15.3 1.4 0.14 12.6 0.0 3.2 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO11635.1 - 0.027 15.0 0.2 0.3 11.6 0.0 2.8 2 0 0 2 2 2 0 ABC transporter BSD PF03909.17 ETO11635.1 - 0.033 14.2 0.4 8.6 6.5 0.1 3.1 2 0 0 2 2 2 0 BSD domain PduV-EutP PF10662.9 ETO11635.1 - 0.034 13.9 0.0 0.091 12.5 0.0 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 ETO11635.1 - 0.065 13.1 0.0 0.29 11.0 0.0 2.1 1 0 0 1 1 1 0 RsgA GTPase AAA_16 PF13191.6 ETO11635.1 - 0.13 12.6 0.1 0.56 10.6 0.1 2.1 1 1 0 1 1 1 0 AAA ATPase domain BUD22 PF09073.10 ETO11636.1 - 0.14 11.5 40.6 0.17 11.2 40.6 1.0 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO11636.1 - 0.95 7.6 34.9 1.1 7.3 34.9 1.1 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.11 ETO11636.1 - 2.7 8.0 47.7 0.2 11.7 40.9 2.0 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Astro_capsid_p PF12226.8 ETO11636.1 - 3.4 6.7 22.1 5.6 6.0 22.1 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein adh_short PF00106.25 ETO11637.1 - 1.7e-20 73.3 0.1 3e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO11637.1 - 9e-13 48.3 0.0 1.4e-07 31.3 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase Glyco_tran_WecB PF03808.13 ETO11637.1 - 0.032 14.2 0.0 0.066 13.2 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family WBP-1 PF11669.8 ETO11637.1 - 0.24 12.0 0.2 0.24 12.0 0.2 5.2 4 2 2 6 6 6 0 WW domain-binding protein 1 ETRAMP PF09716.10 ETO11637.1 - 0.36 10.9 0.0 0.36 10.9 0.0 4.8 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Mito_fiss_reg PF05308.11 ETO11637.1 - 2.5 8.1 10.6 0.37 10.9 6.2 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator SARAF PF06682.12 ETO11637.1 - 7.8 6.0 12.5 0.14 11.8 2.7 2.8 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Kinesin PF00225.23 ETO11640.1 - 1.9e-19 69.8 0.1 2.3e-19 69.5 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO11640.1 - 2.9e-07 30.6 2.3 2e-06 27.8 0.6 2.6 1 1 2 3 3 3 1 Microtubule binding AAA_16 PF13191.6 ETO11640.1 - 0.012 16.0 0.0 0.019 15.4 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ETO11640.1 - 0.022 15.1 0.1 0.048 13.9 0.0 1.7 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ETO11640.1 - 0.071 13.0 0.1 0.17 11.8 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase BCDHK_Adom3 PF10436.9 ETO11642.1 - 1.6e-24 86.6 0.2 2.5e-23 82.7 0.2 2.3 1 1 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ETO11642.1 - 2.5e-08 34.4 0.0 6.5e-08 33.1 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO11642.1 - 0.051 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase B56 PF01603.20 ETO11643.1 - 1e-95 321.2 11.6 4e-95 319.2 11.6 1.8 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) WD40 PF00400.32 ETO11645.1 - 2.2e-05 25.1 0.9 0.00084 20.1 0.0 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat CNOT1_HEAT PF16418.5 ETO11645.1 - 0.017 15.2 0.3 0.022 14.8 0.3 1.3 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Nup160 PF11715.8 ETO11645.1 - 0.023 13.3 0.0 0.043 12.5 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Lipase_GDSL_2 PF13472.6 ETO11646.1 - 0.0076 16.7 0.0 0.0076 16.7 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family DUF4796 PF16044.5 ETO11646.1 - 0.016 14.8 0.1 0.085 12.4 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4796) CRAL_TRIO_2 PF13716.6 ETO11646.1 - 0.075 13.2 0.0 0.089 13.0 0.0 1.1 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain WD40 PF00400.32 ETO11649.1 - 5.6e-21 74.5 17.4 4.6e-07 30.4 0.2 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11649.1 - 7.8e-08 31.4 0.2 0.02 13.6 0.1 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11649.1 - 2.8e-06 27.5 0.0 0.021 15.1 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11649.1 - 0.0027 17.1 1.4 0.015 14.7 1.0 2.2 1 1 1 2 2 2 1 WD40-like domain Cbl_N2 PF02761.14 ETO11649.1 - 0.1 13.3 0.4 0.35 11.6 0.1 2.0 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain Cnd1 PF12717.7 ETO11650.1 - 1.1e-05 25.6 2.6 1.1e-05 25.6 2.6 3.5 2 2 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 DUF3349 PF11829.8 ETO11650.1 - 0.0033 18.2 0.5 14 6.6 0.1 4.2 3 1 0 4 4 4 1 Protein of unknown function (DUF3349) HEAT PF02985.22 ETO11650.1 - 0.005 17.0 0.1 85 3.8 0.0 5.0 5 0 0 5 5 5 0 HEAT repeat RTP1_C1 PF10363.9 ETO11650.1 - 0.011 15.9 0.7 2.5 8.3 0.0 3.9 2 2 2 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 PrkA PF06798.12 ETO11650.1 - 0.012 15.2 0.1 0.073 12.7 0.0 2.1 1 1 1 2 2 2 0 PrkA serine protein kinase C-terminal domain DNA_pol3_gamma3 PF12169.8 ETO11650.1 - 0.027 14.4 0.0 16 5.4 0.0 3.6 2 2 2 4 4 4 0 DNA polymerase III subunits gamma and tau domain III Annexin PF00191.20 ETO11650.1 - 0.2 11.8 1.8 3.4 7.8 0.1 3.5 3 1 0 3 3 3 0 Annexin RST PF12174.8 ETO11650.1 - 0.61 10.1 3.2 15 5.6 0.4 3.9 4 1 0 4 4 4 0 RCD1-SRO-TAF4 (RST) plant domain WD40 PF00400.32 ETO11652.1 - 1.8e-26 91.8 17.2 3.5e-07 30.8 0.1 5.9 5 2 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11652.1 - 5.8e-09 36.1 1.2 0.35 11.2 0.1 4.9 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11652.1 - 7.5e-06 25.5 10.8 0.00063 19.2 0.8 4.1 2 2 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO11652.1 - 7.4e-05 21.6 0.1 1.3 7.5 0.1 3.2 2 1 1 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO11652.1 - 0.0036 17.2 0.2 0.12 12.2 0.0 2.5 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A DUF4221 PF13970.6 ETO11652.1 - 0.028 14.0 3.1 0.25 10.8 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) SseB_C PF14581.6 ETO11653.1 - 0.0064 16.6 0.2 0.21 11.7 0.0 2.7 2 0 0 2 2 2 1 SseB protein C-terminal domain DUF3201 PF11447.8 ETO11653.1 - 0.06 12.9 0.3 0.18 11.3 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3201) RPEL PF02755.15 ETO11653.1 - 0.11 12.3 9.9 0.88 9.4 0.4 4.6 4 1 0 4 4 4 0 RPEL repeat DUF4062 PF13271.6 ETO11653.1 - 0.6 10.5 3.8 2.1 8.8 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4062) IL17R_fnIII_D2 PF16578.5 ETO11653.1 - 2.4 8.7 7.5 0.75 10.4 1.1 2.8 2 0 0 2 2 2 0 Interleukin 17 receptor D Pkinase PF00069.25 ETO11654.1 - 1.1e-05 25.0 0.0 2e-05 24.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11654.1 - 0.0018 17.6 0.0 0.0027 17.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_Tyr PF07714.17 ETO11655.1 - 2.7e-44 151.4 0.0 4.6e-44 150.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO11655.1 - 8.9e-28 97.4 0.0 1.9e-27 96.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO11655.1 - 4.2e-05 22.5 0.4 7.5e-05 21.7 0.0 1.5 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO11655.1 - 0.037 13.4 0.1 0.062 12.6 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ETO11656.1 - 9.5e-20 71.0 0.1 8.3e-14 51.6 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11656.1 - 1.4e-06 27.8 0.0 0.00014 21.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase His_Phos_1 PF00300.22 ETO11657.1 - 0.0062 16.2 5.5 9.1 5.9 0.0 5.0 4 1 1 6 6 6 2 Histidine phosphatase superfamily (branch 1) PXB PF12828.7 ETO11657.1 - 0.024 14.6 1.2 0.71 9.9 0.1 2.9 3 0 0 3 3 3 0 PX-associated PROCN PF08083.11 ETO11657.1 - 0.093 11.4 0.0 0.18 10.5 0.0 1.4 1 0 0 1 1 1 0 PROCN (NUC071) domain BSMAP PF12280.8 ETO11657.1 - 1.1 9.4 11.4 0.17 12.0 4.0 3.0 3 0 0 3 3 3 0 Brain specific membrane anchored protein Peptidase_U57 PF05582.12 ETO11657.1 - 8.4 5.6 12.5 14 4.8 3.9 3.2 3 0 0 3 3 3 0 YabG peptidase U57 HNH_4 PF13395.6 ETO11658.1 - 0.016 15.1 0.2 0.052 13.5 0.0 1.9 2 0 0 2 2 2 0 HNH endonuclease RPN2_C PF18004.1 ETO11658.1 - 0.18 11.7 7.5 0.24 11.3 7.5 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pkinase PF00069.25 ETO11659.1 - 0.00041 19.8 1.2 0.45 9.8 0.0 2.3 1 1 1 2 2 2 2 Protein kinase domain SUKH_5 PF14567.6 ETO11660.1 - 0.0028 17.4 0.1 0.0062 16.3 0.0 1.6 2 0 0 2 2 2 1 SMI1-KNR4 cell-wall TraB PF01963.17 ETO11660.1 - 0.005 16.8 0.4 0.0083 16.1 0.0 1.5 2 0 0 2 2 2 1 TraB family Peptidase_M48_N PF16491.5 ETO11661.1 - 0.12 12.3 0.2 0.18 11.7 0.2 1.2 1 0 0 1 1 1 0 CAAX prenyl protease N-terminal, five membrane helices EFG_IV PF03764.18 ETO11663.1 - 0.0095 15.7 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV DUF166 PF02593.14 ETO11663.1 - 0.027 14.0 0.5 0.032 13.8 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function Radial_spoke PF04712.12 ETO11664.1 - 0.00068 18.7 3.2 0.00078 18.5 3.2 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein Kelch_2 PF07646.15 ETO11664.1 - 0.0032 17.4 0.1 0.0077 16.2 0.1 1.7 1 0 0 1 1 1 1 Kelch motif Kelch_5 PF13854.6 ETO11664.1 - 0.0043 17.0 0.6 0.0086 16.0 0.1 1.7 2 0 0 2 2 2 1 Kelch motif FAM176 PF14851.6 ETO11664.1 - 0.0055 16.4 2.8 0.0084 15.8 2.8 1.3 1 0 0 1 1 1 1 FAM176 family Kelch_4 PF13418.6 ETO11664.1 - 0.0074 16.3 0.0 0.014 15.4 0.0 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO11664.1 - 0.014 15.0 0.0 0.027 14.1 0.0 1.5 1 0 0 1 1 1 0 Kelch motif CPSF100_C PF13299.6 ETO11664.1 - 0.04 14.1 2.0 0.055 13.7 2.0 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sporozoite_P67 PF05642.11 ETO11664.1 - 0.058 11.5 2.1 0.06 11.4 2.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 ETO11664.1 - 0.076 13.4 5.3 0.14 12.6 5.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Nop14 PF04147.12 ETO11664.1 - 0.097 10.9 6.9 0.11 10.6 6.9 1.1 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 ETO11664.1 - 0.12 10.1 3.7 0.14 9.9 3.7 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit S-antigen PF05756.11 ETO11664.1 - 0.13 12.6 4.8 0.26 11.7 4.8 1.4 1 0 0 1 1 1 0 S-antigen protein NOA36 PF06524.12 ETO11664.1 - 0.19 11.0 7.4 0.33 10.2 7.4 1.4 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ETO11664.1 - 0.23 9.7 5.5 0.28 9.4 5.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Phage_Gp23 PF10669.9 ETO11664.1 - 0.31 11.4 5.9 0.65 10.3 5.9 1.5 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) TRAP_alpha PF03896.16 ETO11664.1 - 0.43 9.7 3.9 0.59 9.3 3.9 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Cytomega_UL84 PF06284.11 ETO11664.1 - 1.6 7.1 3.3 1.9 6.9 3.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DNA_pol_phi PF04931.13 ETO11664.1 - 2 6.4 12.2 2.6 6.0 12.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 ETO11664.1 - 2.5 7.8 9.2 3.5 7.3 9.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF2052 PF09747.9 ETO11664.1 - 8.1 6.5 15.1 42 4.2 0.0 2.1 1 1 1 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF2457 PF10446.9 ETO11664.1 - 8.4 5.4 13.7 11 5.0 13.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) F-box PF00646.33 ETO11665.1 - 0.00084 19.2 0.0 0.0014 18.4 0.0 1.3 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO11665.1 - 0.0019 18.0 0.0 0.003 17.4 0.0 1.3 1 0 0 1 1 1 1 F-box-like 2OG-FeII_Oxy_3 PF13640.6 ETO11666.1 - 0.027 15.3 0.1 0.095 13.6 0.1 1.9 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Peptidase_C14 PF00656.22 ETO11667.1 - 7.4e-15 55.6 0.8 1.2e-14 54.9 0.8 1.2 1 0 0 1 1 1 1 Caspase domain IL1_propep PF02394.16 ETO11667.1 - 0.41 11.6 3.7 6.3 7.8 0.2 2.9 2 1 0 2 2 2 0 Interleukin-1 propeptide Peptidase_C14 PF00656.22 ETO11668.1 - 3.9e-05 23.7 0.2 0.00011 22.3 0.1 1.7 1 1 1 2 2 2 1 Caspase domain WD40 PF00400.32 ETO11669.1 - 8.6e-28 96.0 13.2 1.2e-06 29.2 1.7 6.1 5 2 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO11669.1 - 8.5e-07 28.0 0.3 0.057 12.0 0.1 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11669.1 - 1.3e-06 28.5 0.0 0.56 10.6 0.0 4.1 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain RBD PF02196.15 ETO11671.1 - 2.4e-05 24.3 0.1 9.3e-05 22.4 0.0 1.9 2 0 0 2 2 2 1 Raf-like Ras-binding domain Bul1_C PF04426.12 ETO11671.1 - 0.026 13.9 0.2 0.026 13.9 0.2 1.7 2 0 0 2 2 2 0 Bul1 C terminus RA PF00788.23 ETO11671.1 - 0.059 14.0 0.0 0.094 13.4 0.0 1.5 1 0 0 1 1 1 0 Ras association (RalGDS/AF-6) domain Phage_min_tail PF05939.13 ETO11672.1 - 0.04 14.3 0.2 0.067 13.6 0.2 1.4 1 0 0 1 1 1 0 Phage minor tail protein TACC_C PF05010.14 ETO11673.1 - 0.00015 21.7 9.3 0.00015 21.7 9.3 1.7 2 0 0 2 2 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal APG17 PF04108.12 ETO11673.1 - 0.00043 19.5 7.3 0.0009 18.5 3.8 2.0 2 0 0 2 2 2 1 Autophagy protein Apg17 KASH_CCD PF14662.6 ETO11673.1 - 0.00047 20.0 5.7 0.00091 19.1 5.7 1.5 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH DUF724 PF05266.14 ETO11673.1 - 0.0007 19.5 1.6 0.0007 19.5 1.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF724) HMMR_N PF15905.5 ETO11673.1 - 0.0014 18.2 5.8 0.0014 18.2 5.8 1.5 2 0 0 2 2 1 1 Hyaluronan mediated motility receptor N-terminal TMPIT PF07851.13 ETO11673.1 - 0.0016 17.7 6.4 0.0016 17.7 6.4 2.0 2 1 1 3 3 3 1 TMPIT-like protein DUF3450 PF11932.8 ETO11673.1 - 0.0024 17.2 11.3 0.0042 16.4 10.7 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF3450) ALIX_LYPXL_bnd PF13949.6 ETO11673.1 - 0.0044 16.4 7.0 0.0067 15.8 7.0 1.2 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV HemX PF04375.14 ETO11673.1 - 0.0046 16.3 2.2 0.0046 16.3 2.2 1.5 2 0 0 2 2 1 1 HemX, putative uroporphyrinogen-III C-methyltransferase Tropomyosin PF00261.20 ETO11673.1 - 0.0049 16.3 6.8 0.0049 16.3 6.8 1.6 2 0 0 2 2 2 1 Tropomyosin DUF2353 PF09789.9 ETO11673.1 - 0.0061 16.0 7.3 0.011 15.2 7.3 1.4 1 0 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) GAS PF13851.6 ETO11673.1 - 0.0069 15.8 11.4 0.0069 15.8 11.4 1.9 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding CALCOCO1 PF07888.11 ETO11673.1 - 0.0075 15.2 4.7 0.012 14.5 4.7 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Atg14 PF10186.9 ETO11673.1 - 0.012 14.7 4.6 0.023 13.8 4.6 1.4 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CENP-F_leu_zip PF10473.9 ETO11673.1 - 0.013 15.5 10.2 0.013 15.5 10.2 1.8 2 1 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 ETO11673.1 - 0.013 14.1 3.1 0.019 13.6 3.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Spc7 PF08317.11 ETO11673.1 - 0.014 14.3 12.4 0.053 12.4 12.4 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF935 PF06074.12 ETO11673.1 - 0.015 14.1 0.3 0.016 14.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF935) DUF1664 PF07889.12 ETO11673.1 - 0.019 15.0 8.5 0.049 13.7 5.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Jnk-SapK_ap_N PF09744.9 ETO11673.1 - 0.02 15.1 9.9 0.02 15.1 9.9 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 O-antigen_lig PF13425.6 ETO11673.1 - 0.022 13.6 3.4 0.041 12.7 3.4 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein bZIP_1 PF00170.21 ETO11673.1 - 0.024 14.7 9.2 0.037 14.1 3.6 2.8 1 1 1 2 2 2 0 bZIP transcription factor Tektin PF03148.14 ETO11673.1 - 0.025 13.3 9.8 0.04 12.7 9.2 1.6 1 1 0 1 1 1 0 Tektin family DUF4337 PF14235.6 ETO11673.1 - 0.03 14.4 4.1 0.091 12.9 3.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) SURF4 PF02077.15 ETO11673.1 - 0.037 13.6 2.9 1.3 8.5 2.3 2.3 2 0 0 2 2 2 0 SURF4 family BLOC1_2 PF10046.9 ETO11673.1 - 0.039 14.3 2.6 0.039 14.3 2.6 2.6 2 1 1 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 AI-2E_transport PF01594.16 ETO11673.1 - 0.058 12.5 6.1 0.3 10.2 0.7 2.1 1 1 1 2 2 2 0 AI-2E family transporter Occludin_ELL PF07303.13 ETO11673.1 - 0.062 14.0 6.8 0.13 13.0 6.3 1.9 1 1 0 1 1 1 0 Occludin homology domain Phlebovirus_NSM PF07246.11 ETO11673.1 - 0.14 11.5 4.9 0.28 10.5 4.9 1.5 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF812 PF05667.11 ETO11673.1 - 0.14 11.0 11.8 0.18 10.6 11.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Snapin_Pallidin PF14712.6 ETO11673.1 - 0.18 12.3 8.4 0.39 11.2 8.4 1.6 1 0 0 1 1 1 0 Snapin/Pallidin DivIC PF04977.15 ETO11673.1 - 0.22 11.3 15.2 0.29 10.9 9.5 3.1 2 1 0 2 2 1 0 Septum formation initiator CorA PF01544.18 ETO11673.1 - 0.29 10.4 6.7 0.53 9.5 6.7 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein TFR_dimer PF04253.15 ETO11673.1 - 0.32 11.1 5.3 0.33 11.0 2.9 2.2 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain SlyX PF04102.12 ETO11673.1 - 0.33 11.6 6.8 1.4 9.6 0.9 2.5 1 1 1 2 2 2 0 SlyX T2SSF PF00482.23 ETO11673.1 - 0.38 10.7 0.1 0.38 10.7 0.1 1.8 2 0 0 2 2 1 0 Type II secretion system (T2SS), protein F CENP-Q PF13094.6 ETO11673.1 - 0.38 10.9 9.5 0.19 11.9 4.5 2.3 3 0 0 3 3 2 0 CENP-Q, a CENPA-CAD centromere complex subunit FUN14 PF04930.15 ETO11673.1 - 0.56 10.6 3.7 1 9.8 2.3 2.1 2 1 0 2 2 2 0 FUN14 family STAT_alpha PF01017.20 ETO11673.1 - 0.57 10.1 21.9 0.028 14.3 13.2 2.7 3 1 0 3 3 1 0 STAT protein, all-alpha domain DASH_Dad2 PF08654.10 ETO11673.1 - 0.59 10.6 10.9 0.96 9.9 3.1 3.1 3 1 1 4 4 3 0 DASH complex subunit Dad2 Laminin_II PF06009.12 ETO11673.1 - 0.71 9.9 14.4 0.064 13.3 9.2 1.8 2 1 0 2 2 1 0 Laminin Domain II WXG100 PF06013.12 ETO11673.1 - 0.73 10.1 6.7 2.6 8.4 3.6 3.0 2 1 0 2 2 1 0 Proteins of 100 residues with WXG HIP1_clath_bdg PF16515.5 ETO11673.1 - 0.79 10.4 15.8 0.077 13.6 10.2 2.2 2 0 0 2 2 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2570 PF10828.8 ETO11673.1 - 0.97 9.3 10.2 0.063 13.1 4.8 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF2570) Syntaxin-6_N PF09177.11 ETO11673.1 - 1.1 9.9 10.4 0.23 12.0 5.6 2.3 2 1 0 2 2 1 0 Syntaxin 6, N-terminal DUF4763 PF15960.5 ETO11673.1 - 1.2 8.4 12.7 0.11 11.7 6.8 2.1 2 1 1 3 3 2 0 Domain of unknown function (DUF4763) EMC3_TMCO1 PF01956.16 ETO11673.1 - 1.9 8.2 7.0 0.73 9.5 3.9 1.8 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Phage_GP20 PF06810.11 ETO11673.1 - 2.3 8.0 20.1 0.15 11.9 13.9 2.2 2 1 0 2 2 1 0 Phage minor structural protein GP20 Tup_N PF08581.10 ETO11673.1 - 2.4 8.5 13.6 1.9 8.8 0.6 2.5 1 1 1 2 2 2 0 Tup N-terminal Fib_alpha PF08702.10 ETO11673.1 - 2.6 8.2 12.0 8.2 6.6 12.0 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family FlaC_arch PF05377.11 ETO11673.1 - 2.6 8.5 13.5 0.55 10.7 4.6 3.3 2 1 2 4 4 3 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 ETO11673.1 - 2.6 8.4 8.6 3.1 8.1 6.1 2.6 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) YlbD_coat PF14071.6 ETO11673.1 - 2.9 8.2 15.7 0.033 14.5 6.7 2.2 2 1 0 2 2 1 0 Putative coat protein DUF601 PF04642.12 ETO11673.1 - 4 6.9 8.7 0.28 10.7 1.0 2.2 2 1 1 3 3 2 0 Protein of unknown function, DUF601 NPV_P10 PF05531.12 ETO11673.1 - 4 8.0 10.3 3.9 8.0 6.1 2.3 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4446 PF14584.6 ETO11673.1 - 4.9 7.1 9.9 0.37 10.8 3.0 2.4 2 1 1 3 3 2 0 Protein of unknown function (DUF4446) DUF16 PF01519.16 ETO11673.1 - 6 7.4 12.5 1.3 9.5 8.8 1.8 2 0 0 2 2 1 0 Protein of unknown function DUF16 UPF0242 PF06785.11 ETO11673.1 - 6.7 6.8 16.2 0.37 10.9 10.3 1.9 2 1 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus UPF0449 PF15136.6 ETO11673.1 - 7.9 7.0 11.3 0.39 11.2 4.6 2.2 2 1 0 2 2 1 0 Uncharacterised protein family UPF0449 PRKG1_interact PF15898.5 ETO11673.1 - 8.9 7.3 15.6 0.22 12.5 7.3 2.3 3 0 0 3 3 2 0 cGMP-dependent protein kinase interacting domain APG6_N PF17675.1 ETO11673.1 - 9.8 6.7 17.4 0.36 11.4 10.2 2.2 3 0 0 3 3 1 0 Apg6 coiled-coil region Copine PF07002.16 ETO11674.1 - 4.8e-16 58.9 0.0 6.2e-16 58.5 0.0 1.1 1 0 0 1 1 1 1 Copine RIC1 PF07064.13 ETO11676.1 - 0.0024 17.3 0.3 0.0027 17.1 0.3 1.1 1 0 0 1 1 1 1 RIC1 WD40 PF00400.32 ETO11678.1 - 3.9e-58 192.1 20.6 7.8e-08 32.9 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11678.1 - 6.7e-20 71.2 4.2 0.00068 19.9 0.0 6.7 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11678.1 - 1.9e-18 66.6 1.2 0.0012 17.9 0.0 6.1 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO11678.1 - 1.9e-07 30.1 7.4 0.014 14.1 0.2 4.5 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11678.1 - 0.00014 21.3 3.5 0.064 12.6 0.1 3.5 1 1 1 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO11678.1 - 0.0054 16.6 2.0 24 5.0 0.0 5.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Big_7 PF17957.1 ETO11678.1 - 0.026 15.3 0.2 1.7 9.5 0.0 3.5 4 0 0 4 4 4 0 Bacterial Ig domain SMN PF06003.12 ETO11678.1 - 0.027 13.7 1.6 0.043 13.1 1.6 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) DUF4838 PF16126.5 ETO11678.1 - 0.035 13.5 3.5 0.044 13.2 2.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4838) WD40 PF00400.32 ETO11679.1 - 9.1e-10 39.0 4.7 3.2e-05 24.6 0.2 3.2 4 1 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO11679.1 - 0.0068 15.1 0.1 2.1 6.9 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO11679.1 - 0.0085 16.1 0.1 0.012 15.7 0.1 1.3 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 2, middle region PUD PF03714.14 ETO11679.1 - 0.079 13.8 0.3 3.6 8.5 0.3 2.4 1 1 0 1 1 1 0 Bacterial pullanase-associated domain RRM_1 PF00076.22 ETO11680.1 - 2.1e-22 78.7 0.0 3.4e-22 78.0 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ETO11680.1 - 7.8e-22 77.2 2.0 1.4e-21 76.4 2.0 1.4 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Atg14 PF10186.9 ETO11681.1 - 0.0063 15.6 2.1 0.0091 15.1 2.1 1.2 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 ETO11681.1 - 0.021 15.4 3.4 0.033 14.8 3.4 1.2 1 0 0 1 1 1 0 Initiation control protein YabA DivIC PF04977.15 ETO11681.1 - 0.043 13.6 1.0 0.083 12.7 0.7 1.6 1 1 0 1 1 1 0 Septum formation initiator Methyltransf_28 PF02636.17 ETO11684.1 - 1.3e-16 61.1 0.0 1.4e-16 60.9 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase Pec_lyase_C PF00544.19 ETO11685.1 - 0.018 14.7 0.1 0.026 14.1 0.1 1.2 1 0 0 1 1 1 0 Pectate lyase MatP_C PF17414.2 ETO11685.1 - 0.13 12.5 0.7 0.23 11.7 0.2 1.7 2 0 0 2 2 2 0 MatP C-terminal ribbon-helix-helix domain Exo_endo_phos_2 PF14529.6 ETO11686.1 - 0.018 14.9 0.0 0.03 14.1 0.0 1.4 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase DUF2430 PF10353.9 ETO11687.1 - 0.017 15.5 0.2 0.04 14.3 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) dCache_1 PF02743.18 ETO11688.1 - 0.01 15.7 0.7 0.014 15.2 0.7 1.4 1 1 0 1 1 1 0 Cache domain Transp_cyt_pur PF02133.15 ETO11691.1 - 0.063 12.0 0.4 0.14 10.9 0.1 1.5 1 1 1 2 2 2 0 Permease for cytosine/purines, uracil, thiamine, allantoin HSF_DNA-bind PF00447.17 ETO11691.1 - 0.49 11.0 5.5 1.7 9.3 5.5 2.1 1 1 0 1 1 1 0 HSF-type DNA-binding Myosin_head PF00063.21 ETO11692.1 - 1.9e-128 429.6 9.9 6.5e-128 427.8 9.9 2.0 1 1 0 1 1 1 1 Myosin head (motor domain) WD40 PF00400.32 ETO11695.1 - 4.5e-114 369.1 48.5 1.6e-08 35.1 0.2 14.9 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11695.1 - 1.5e-20 73.2 15.9 0.11 12.8 0.0 10.7 1 1 10 12 12 12 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11695.1 - 5.9e-15 55.1 8.6 0.075 12.0 0.2 10.3 1 1 10 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO11695.1 - 1.6e-11 44.4 0.0 3.4e-11 43.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO11695.1 - 3.3e-07 29.8 4.5 8.2e-07 28.6 4.5 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO11695.1 - 3.4e-05 23.9 0.5 9.3e-05 22.5 0.5 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO11695.1 - 0.00041 20.6 0.0 0.0019 18.5 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO11695.1 - 0.0053 17.3 0.2 0.025 15.1 0.0 2.3 2 0 0 2 2 2 1 AAA domain Pentapeptide_3 PF13576.6 ETO11695.1 - 0.044 13.9 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA_29 PF13555.6 ETO11695.1 - 0.086 12.6 0.0 0.33 10.7 0.0 2.1 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ETO11695.1 - 0.13 12.4 0.0 11 6.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain DAP3 PF10236.9 ETO11695.1 - 4.3 6.4 8.5 0.47 9.6 0.1 2.8 2 1 0 3 3 3 0 Mitochondrial ribosomal death-associated protein 3 WD40 PF00400.32 ETO11696.1 - 1.1e-19 70.4 1.0 6.2e-10 39.5 0.2 3.2 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11696.1 - 3.6e-06 27.2 1.9 0.00013 22.2 0.0 3.5 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.6 ETO11696.1 - 0.024 14.6 0.4 0.07 13.1 0.1 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO11696.1 - 0.047 14.0 0.0 0.12 12.7 0.0 1.7 1 0 0 1 1 1 0 Galactose oxidase, central domain DUF4746 PF15928.5 ETO11698.1 - 0.31 10.4 13.2 0.37 10.2 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2828 PF11443.8 ETO11698.1 - 0.88 7.6 16.4 1.1 7.3 16.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DDRGK PF09756.9 ETO11698.1 - 1.2 8.7 28.4 1.5 8.4 28.4 1.2 1 0 0 1 1 1 0 DDRGK domain Sec62 PF03839.16 ETO11698.1 - 1.4 8.4 17.6 1.6 8.2 17.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO11698.1 - 1.5 7.5 14.1 1.5 7.5 14.1 1.0 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 ETO11698.1 - 1.9 7.4 15.2 2.3 7.1 15.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) RR_TM4-6 PF06459.12 ETO11698.1 - 2.6 7.8 16.7 3 7.6 16.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4820 PF16091.5 ETO11698.1 - 3.4 7.0 11.5 4.9 6.5 11.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Cellulose_synt PF03552.14 ETO11698.1 - 3.6 6.0 8.5 3.7 5.9 8.5 1.0 1 0 0 1 1 1 0 Cellulose synthase RPOL_N PF14700.6 ETO11698.1 - 4.4 6.6 15.4 4.9 6.4 15.4 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DDHD PF02862.17 ETO11698.1 - 4.5 7.4 8.3 5 7.2 8.3 1.2 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 ETO11698.1 - 5.4 5.7 19.9 5.8 5.6 19.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PPL5 PF18168.1 ETO11698.1 - 5.8 6.1 15.3 6.7 5.9 15.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Hid1 PF12722.7 ETO11698.1 - 6.7 4.7 9.5 6.7 4.7 9.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 ETO11698.1 - 7.8 5.4 14.5 8.5 5.3 14.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 NACHT PF05729.12 ETO11699.1 - 7.4e-08 32.5 0.0 2.1e-07 31.0 0.0 1.8 1 0 0 1 1 1 1 NACHT domain PP1c_bdg PF10488.9 ETO11700.1 - 0.016 14.7 0.2 0.025 14.0 0.2 1.3 1 0 0 1 1 1 0 Phosphatase-1 catalytic subunit binding region WD40 PF00400.32 ETO11701.1 - 9.4e-25 86.4 17.8 5.5e-06 27.0 0.4 5.4 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO11701.1 - 1.1e-12 47.4 1.0 0.0012 17.6 0.0 4.0 2 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11701.1 - 4.3e-09 36.5 0.5 0.0075 16.5 0.0 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11701.1 - 1.6e-05 24.4 5.8 0.00071 19.0 0.9 3.5 2 1 1 3 3 3 2 WD40-like domain WD40 PF00400.32 ETO11703.1 - 5.6e-27 93.4 16.0 9.4e-06 26.3 0.1 6.4 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11703.1 - 1.9e-08 34.5 0.6 0.075 13.3 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11703.1 - 0.00028 19.7 3.8 1.7 7.2 0.0 4.1 3 2 2 5 5 5 3 Nucleoporin Nup120/160 TPR_12 PF13424.6 ETO11705.1 - 4.2e-11 43.0 0.0 1.3e-10 41.4 0.0 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11705.1 - 3e-09 36.3 2.7 9.9e-09 34.7 2.7 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11705.1 - 8.5e-09 34.9 2.9 3.4e-08 33.1 2.9 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11705.1 - 2.3e-08 33.7 0.0 6.4e-08 32.2 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11705.1 - 2.4e-08 33.4 0.1 5.8e-08 32.2 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11705.1 - 3.2e-07 30.0 2.2 9.4e-07 28.5 2.2 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11705.1 - 0.00084 19.0 1.9 0.0023 17.6 1.0 2.2 2 0 0 2 2 2 1 TPR repeat TPR_6 PF13174.6 ETO11705.1 - 0.0036 17.8 0.4 0.0087 16.6 0.4 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat PIN7 PF18475.1 ETO11705.1 - 0.0054 17.3 5.7 0.097 13.3 0.1 3.2 3 0 0 3 3 3 1 PIN domain Pox_TAA1 PF03295.14 ETO11705.1 - 0.0071 16.2 0.2 0.42 10.5 0.1 2.7 2 0 0 2 2 2 1 Poxvirus trans-activator protein A1 C-terminal TPR_14 PF13428.6 ETO11705.1 - 0.011 16.5 0.1 0.023 15.5 0.1 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO11705.1 - 0.031 14.1 0.2 0.031 14.1 0.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETO11705.1 - 0.059 14.0 0.0 0.1 13.3 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11705.1 - 0.067 13.6 0.0 0.36 11.3 0.0 2.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Cys_knot PF00007.22 ETO11706.1 - 0.0014 18.9 5.3 0.0014 18.9 5.3 2.3 1 1 2 3 3 3 1 Cystine-knot domain Neugrin PF06413.11 ETO11706.1 - 0.0055 16.8 1.1 0.0067 16.5 1.1 1.3 1 0 0 1 1 1 1 Neugrin LMBR1 PF04791.16 ETO11706.1 - 0.12 11.3 7.5 0.14 11.0 7.5 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Arm-DNA-bind_5 PF17293.2 ETO11706.1 - 2.7 8.5 13.2 0.15 12.5 6.3 2.2 2 0 0 2 2 2 0 Arm DNA-binding domain Aldedh PF00171.22 ETO11708.1 - 3.8e-21 75.2 0.5 3.4e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 Aldehyde dehydrogenase family WD40 PF00400.32 ETO11709.1 - 1.8e-65 215.3 23.2 5.8e-10 39.6 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11709.1 - 2.4e-21 75.8 3.0 0.019 15.2 0.0 6.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11709.1 - 3.2e-13 49.3 0.0 0.14 11.1 0.0 6.0 2 2 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11709.1 - 1.6e-09 37.6 0.3 0.0064 15.9 0.0 3.3 2 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO11709.1 - 1.7e-08 34.2 9.5 4.6 7.3 0.0 7.4 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO11709.1 - 3.2e-06 26.1 5.2 2.6 6.6 0.0 5.3 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO11709.1 - 1.5e-05 24.2 0.5 7.8e-05 21.9 0.4 1.9 1 1 1 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO11709.1 - 2.3e-05 23.1 0.1 0.16 10.4 0.0 3.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain NodS PF05401.11 ETO11709.1 - 0.005 16.5 0.0 0.025 14.2 0.0 2.2 2 0 0 2 2 2 1 Nodulation protein S (NodS) Str_synth PF03088.16 ETO11709.1 - 0.0065 16.6 0.1 4.8 7.4 0.0 4.3 3 3 2 5 5 5 1 Strictosidine synthase Nucleoporin_N PF08801.11 ETO11709.1 - 0.013 14.3 8.1 2.9 6.5 0.9 4.5 1 1 3 4 4 4 0 Nup133 N terminal like VID27 PF08553.10 ETO11709.1 - 0.019 14.1 0.0 3.9 6.4 0.0 2.5 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain DPPIV_N PF00930.21 ETO11709.1 - 0.02 13.6 0.3 4.4 6.0 0.1 3.6 3 2 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region AcetylCoA_hyd_C PF13336.6 ETO11709.1 - 0.029 14.3 0.0 14 5.6 0.0 3.1 3 0 0 3 3 3 0 Acetyl-CoA hydrolase/transferase C-terminal domain Proteasome_A_N PF10584.9 ETO11709.1 - 0.38 10.5 15.2 14 5.5 0.0 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Ras PF00071.22 ETO11710.1 - 9.4e-05 22.1 0.0 0.00019 21.0 0.0 1.5 1 0 0 1 1 1 1 Ras family UPF0239 PF06783.11 ETO11710.1 - 0.024 14.8 5.5 0.045 13.9 5.5 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Connexin PF00029.19 ETO11710.1 - 0.53 10.0 6.4 0.43 10.3 5.4 1.3 1 1 0 1 1 1 0 Connexin BID PF06393.11 ETO11711.1 - 0.048 13.2 0.0 0.099 12.2 0.0 1.5 1 0 0 1 1 1 0 BH3 interacting domain (BID) WD40 PF00400.32 ETO11712.1 - 5.2e-37 125.2 30.0 6.1e-06 26.9 2.2 7.2 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11712.1 - 1.2e-09 38.3 1.7 0.12 12.7 0.0 5.3 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11712.1 - 2.1e-08 33.3 2.6 0.14 10.8 0.1 4.9 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Pfg27 PF09216.10 ETO11712.1 - 0.03 14.2 1.9 0.3 10.9 0.3 2.2 2 0 0 2 2 2 0 Pfg27 DUF4979 PF16351.5 ETO11712.1 - 0.17 12.1 2.1 41 4.4 0.1 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) Ras PF00071.22 ETO11713.1 - 8.6e-19 67.7 0.1 1.8e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO11713.1 - 6.9e-13 48.9 0.1 1.7e-12 47.6 0.1 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO11713.1 - 0.00033 20.2 0.4 0.00066 19.2 0.4 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family STPPase_N PF16891.5 ETO11713.1 - 0.00059 20.2 1.8 0.00066 20.1 0.1 2.0 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain TniB PF05621.11 ETO11713.1 - 0.00084 18.8 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 Bacterial TniB protein TPR_12 PF13424.6 ETO11714.1 - 3.2e-05 24.1 0.1 5.4e-05 23.4 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11714.1 - 0.0073 16.1 4.4 0.082 12.8 0.5 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11714.1 - 0.14 12.5 3.3 0.36 11.2 0.5 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11714.1 - 0.59 9.9 2.8 11 5.8 0.2 2.5 2 0 0 2 2 2 0 TPR repeat WD40 PF00400.32 ETO11715.1 - 1.4e-11 44.7 8.4 4.5e-05 24.1 0.4 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11715.1 - 0.00059 18.6 5.7 0.79 8.3 0.0 3.9 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11715.1 - 0.00079 19.7 0.1 4.5 7.6 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO11715.1 - 0.0023 16.8 1.0 0.0033 16.2 1.0 1.3 1 0 0 1 1 1 1 Nup133 N terminal like WD40 PF00400.32 ETO11716.1 - 2.4e-20 72.5 13.3 1.2e-06 29.2 0.9 4.8 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11716.1 - 6e-05 21.9 1.9 0.32 9.6 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11716.1 - 9.8e-05 22.6 1.2 0.19 12.1 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO11716.1 - 0.0078 16.2 1.3 0.17 12.0 0.3 2.5 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO11717.1 - 2.2e-68 224.5 22.5 1.3e-09 38.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11717.1 - 9.5e-24 83.5 6.8 0.0012 19.1 0.0 6.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11717.1 - 1.7e-13 50.2 0.7 0.41 9.6 0.0 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO11717.1 - 8.6e-13 48.6 0.9 0.00038 20.4 0.2 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO11717.1 - 1.5e-10 40.9 3.3 0.01 15.2 0.1 4.2 2 1 3 5 5 5 5 WD40-like domain Nup160 PF11715.8 ETO11717.1 - 3.8e-09 35.8 1.6 4.2 5.9 0.0 5.9 1 1 4 6 6 6 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO11717.1 - 0.00017 20.5 10.7 1.1 7.9 0.9 5.2 1 1 5 6 6 6 3 Nup133 N terminal like DUF5570 PF17731.1 ETO11717.1 - 0.00046 20.3 1.9 22 5.1 0.0 5.1 1 1 3 5 5 5 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO11717.1 - 0.0013 18.6 6.2 49 4.0 0.0 6.5 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat DUF1652 PF07865.11 ETO11717.1 - 0.0027 17.5 0.0 26 4.7 0.0 4.3 5 0 0 5 5 5 0 Protein of unknown function (DUF1652) SBD PF17882.1 ETO11717.1 - 0.019 14.8 2.6 1.3 8.8 0.0 3.9 2 2 3 5 5 5 0 OAA-family lectin sugar binding domain Prot_ATP_ID_OB PF16450.5 ETO11717.1 - 0.2 11.6 0.1 2.7 8.0 0.0 2.7 3 0 0 3 3 3 0 Proteasomal ATPase OB C-terminal domain WD40 PF00400.32 ETO11718.1 - 2.6e-57 189.4 16.4 3.9e-09 37.0 0.2 8.2 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11718.1 - 2.5e-25 88.6 3.6 0.00054 20.2 0.1 8.1 3 1 6 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO11718.1 - 1.5e-12 47.8 0.3 3.5e-05 23.8 0.1 4.0 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO11718.1 - 3.7e-11 42.6 0.7 1.1 8.2 0.0 6.0 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11718.1 - 7.7e-11 41.9 5.0 0.00018 21.0 0.2 4.7 3 2 2 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO11718.1 - 4e-07 29.1 0.6 0.63 8.6 0.0 4.6 1 1 1 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO11718.1 - 0.0002 21.2 7.0 3.4 7.7 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat HPS3_N PF14761.6 ETO11718.1 - 0.00051 19.6 0.0 1.2 8.6 0.0 3.5 4 0 0 4 4 4 2 Hermansky-Pudlak syndrome 3 DUF5570 PF17731.1 ETO11718.1 - 0.0015 18.7 1.9 1.7 8.8 0.0 4.2 1 1 1 4 4 4 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO11718.1 - 0.0018 16.9 2.2 1.8 7.0 0.1 4.1 3 1 2 5 5 5 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO11718.1 - 0.07 13.1 0.3 11 6.1 0.2 4.1 5 0 0 5 5 5 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO11718.1 - 0.14 11.0 2.9 18 4.1 0.1 4.0 4 2 1 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETO11718.1 - 0.65 9.7 7.3 10 5.9 0.0 4.8 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature RNA_pol_Rpb2_2 PF04561.14 ETO11719.1 - 0.053 13.1 0.1 7.7 6.1 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 2 Aldedh PF00171.22 ETO11720.1 - 1.5e-91 307.3 0.0 7.1e-89 298.4 0.0 2.2 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Methyltransf_3 PF01596.17 ETO11720.1 - 0.079 12.1 0.1 0.17 11.0 0.1 1.5 1 0 0 1 1 1 0 O-methyltransferase WD40 PF00400.32 ETO11721.1 - 6.7e-14 52.1 5.2 0.0017 19.2 0.0 4.6 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11721.1 - 0.00041 20.6 0.1 1.3 9.4 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11721.1 - 0.0016 17.2 0.2 1.7 7.2 0.0 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 VWA_2 PF13519.6 ETO11722.1 - 0.0017 19.0 0.0 0.0032 18.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO11722.1 - 0.0041 17.4 0.3 0.094 13.0 0.0 2.9 1 1 1 2 2 2 2 von Willebrand factor type A domain DUF1330 PF07045.11 ETO11723.1 - 0.0042 17.4 0.0 0.0051 17.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1330) DUF2968 PF11180.8 ETO11723.1 - 0.027 14.1 0.1 0.038 13.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2968) HMGL-like PF00682.19 ETO11726.1 - 0.023 14.2 2.2 0.12 11.9 0.7 2.1 2 0 0 2 2 2 0 HMGL-like DUF2312 PF10073.9 ETO11726.1 - 0.18 11.4 4.8 5 6.9 0.1 3.5 4 1 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF4600 PF15372.6 ETO11726.1 - 1 9.8 18.5 0.39 11.1 2.1 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4600) PP2C_C PF07830.13 ETO11726.1 - 2.9 8.4 5.2 7.2 7.1 0.0 3.3 4 0 0 4 4 4 0 Protein serine/threonine phosphatase 2C, C-terminal domain FHIPEP PF00771.20 ETO11726.1 - 3.1 6.2 5.9 26 3.1 5.7 1.9 1 1 0 1 1 1 0 FHIPEP family Spectrin PF00435.21 ETO11726.1 - 5.2 7.6 12.0 1.6 9.3 1.0 3.3 3 1 1 4 4 4 0 Spectrin repeat Mon2_C PF16206.5 ETO11727.1 - 0.029 12.5 0.0 0.086 11.0 0.0 1.7 2 0 0 2 2 2 0 C-terminal region of Mon2 protein Scm3 PF10384.9 ETO11727.1 - 0.23 11.2 2.6 9.3 6.1 0.3 2.8 3 0 0 3 3 3 0 Centromere protein Scm3 TPR_12 PF13424.6 ETO11728.1 - 9.4e-124 403.9 55.4 3.5e-20 72.1 0.3 12.0 7 3 7 14 14 13 13 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11728.1 - 6.6e-76 248.4 28.4 1.3e-06 28.1 0.0 18.5 20 0 0 20 20 19 14 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11728.1 - 1.1e-68 224.4 92.7 3.1e-07 29.9 0.7 19.9 19 1 0 19 19 19 12 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11728.1 - 2.4e-56 183.7 29.0 6e-05 22.8 0.0 16.7 17 0 0 17 17 16 11 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11728.1 - 3.3e-52 170.4 80.7 6.5e-06 25.9 0.6 17.9 19 0 0 19 19 17 13 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11728.1 - 3.7e-49 160.9 94.3 2.7e-06 27.2 0.5 17.2 18 1 0 18 18 16 12 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11728.1 - 5.1e-19 67.2 31.1 0.028 14.8 0.2 14.2 15 0 0 15 15 12 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11728.1 - 2.2e-18 65.4 1.4 5.7 8.0 0.0 12.8 13 1 1 14 14 14 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO11728.1 - 1.3e-15 57.7 5.5 0.76 10.5 0.0 10.6 8 2 2 11 11 11 4 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO11728.1 - 6.6e-14 52.0 0.1 0.01 15.2 0.0 5.4 3 1 2 6 6 6 4 MalT-like TPR region SHNi-TPR PF10516.9 ETO11728.1 - 1.4e-12 46.9 6.7 0.0066 15.9 0.0 9.1 11 0 0 11 11 11 3 SHNi-TPR TPR_11 PF13414.6 ETO11728.1 - 8.7e-11 41.3 70.8 0.0017 18.0 1.2 16.4 16 2 1 17 17 16 4 TPR repeat TPR_19 PF14559.6 ETO11728.1 - 9.2e-11 42.1 8.6 0.0098 16.4 0.1 8.0 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11728.1 - 2.8e-06 27.6 29.0 2.2 9.1 0.2 12.0 15 0 0 15 15 10 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO11728.1 - 1.7e-05 24.7 54.0 0.42 10.4 0.2 12.0 8 4 5 13 13 12 3 Domain of unknown function (DUF5113) NRBF2_MIT PF17169.4 ETO11728.1 - 0.00079 19.6 1.5 1.5 9.1 0.0 3.8 3 0 0 3 3 2 1 MIT domain of nuclear receptor-binding factor 2 TPR_9 PF13371.6 ETO11728.1 - 0.0029 17.7 0.0 14 5.9 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO11728.1 - 0.058 13.0 11.6 1.6 8.4 0.1 7.0 7 1 0 7 7 7 0 Helix-turn-helix bacterial domain DUF2225 PF09986.9 ETO11728.1 - 0.12 12.1 47.3 2.3 7.9 0.5 8.7 3 2 5 8 8 8 0 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 ETO11728.1 - 0.14 12.9 30.3 2.5 8.9 0.0 9.9 11 0 0 11 11 8 0 Sel1 repeat SPO22 PF08631.10 ETO11728.1 - 0.77 9.2 26.7 0.38 10.2 0.3 6.6 6 1 0 7 7 7 0 Meiosis protein SPO22/ZIP4 like DUF4810 PF16068.5 ETO11728.1 - 0.83 10.2 14.0 24 5.5 0.1 7.2 7 1 1 8 8 7 0 Domain of unknown function (DUF4810) PPR PF01535.20 ETO11728.1 - 2.8 8.4 21.3 52 4.4 0.0 9.7 11 0 0 11 11 9 0 PPR repeat TPR_3 PF07720.12 ETO11728.1 - 3.4 7.7 52.5 2.9 8.0 0.9 12.3 12 1 0 12 12 12 0 Tetratricopeptide repeat MIT PF04212.18 ETO11728.1 - 4.6 7.4 54.3 1.4 9.1 1.1 13.1 14 1 2 16 16 15 0 MIT (microtubule interacting and transport) domain U-box PF04564.15 ETO11729.1 - 3.5e-05 23.9 0.1 0.0001 22.4 0.1 1.8 1 0 0 1 1 1 1 U-box domain FUN14 PF04930.15 ETO11729.1 - 1.5 9.3 3.5 1.4 9.4 0.3 2.4 2 0 0 2 2 2 0 FUN14 family DUF5344 PF17279.2 ETO11729.1 - 5.5 7.6 11.9 5.7 7.6 3.3 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5344) Mcp5_PH PF12814.7 ETO11730.1 - 0.0014 18.8 0.1 0.0018 18.4 0.1 1.2 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Nup188 PF10487.9 ETO11730.1 - 0.0095 13.9 0.3 0.011 13.7 0.3 1.0 1 0 0 1 1 1 1 Nucleoporin subcomplex protein binding to Pom34 zf-met PF12874.7 ETO11730.1 - 0.011 16.1 3.7 0.41 11.1 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type CDC45 PF02724.14 ETO11731.1 - 0.004 15.5 1.2 0.004 15.5 1.2 1.4 2 0 0 2 2 2 1 CDC45-like protein BSP_II PF05432.11 ETO11731.1 - 0.04 13.6 18.9 0.071 12.8 18.9 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4637 PF15470.6 ETO11731.1 - 0.055 13.2 5.6 0.1 12.4 5.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sec62 PF03839.16 ETO11731.1 - 0.095 12.2 0.1 0.22 11.0 0.1 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3292 PF11696.8 ETO11731.1 - 1.7 6.9 5.3 2.5 6.4 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DAP PF15228.6 ETO11731.1 - 5.5 8.2 5.5 29 5.9 1.3 2.5 2 0 0 2 2 2 0 Death-associated protein TPX2 PF06886.11 ETO11731.1 - 7.5 6.9 15.8 17 5.7 15.8 1.6 1 0 0 1 1 1 0 Targeting protein for Xklp2 (TPX2) Glyco_hydro_67C PF07477.12 ETO11732.1 - 0.0012 18.5 0.5 0.0023 17.5 0.5 1.5 1 0 0 1 1 1 1 Glycosyl hydrolase family 67 C-terminus MHCassoc_trimer PF08831.10 ETO11732.1 - 0.011 15.7 3.5 0.024 14.6 0.4 2.5 2 0 0 2 2 2 0 Class II MHC-associated invariant chain trimerisation domain RNase_J_C PF17770.1 ETO11732.1 - 0.076 14.1 7.4 0.15 13.1 0.7 3.2 3 0 0 3 3 3 0 Ribonuclease J C-terminal domain EF-hand_1 PF00036.32 ETO11733.1 - 3.2e-21 73.2 9.3 4.2e-06 25.9 0.4 5.3 6 0 0 6 6 6 3 EF hand EF-hand_7 PF13499.6 ETO11733.1 - 2.8e-20 72.5 10.4 1.2e-09 38.4 0.5 3.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO11733.1 - 1.1e-16 59.3 10.9 8.4e-05 22.2 0.4 5.1 5 1 0 6 6 6 3 EF-hand domain EF-hand_5 PF13202.6 ETO11733.1 - 5.7e-16 57.2 9.8 7.2e-05 22.1 0.3 4.7 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO11733.1 - 1.8e-14 53.3 2.1 6.5e-06 25.9 1.7 3.1 2 0 0 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO11733.1 - 0.00012 22.4 2.1 0.023 15.0 0.2 3.0 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO11733.1 - 0.0085 16.0 2.5 0.52 10.3 0.0 3.1 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand p25-alpha PF05517.12 ETO11733.1 - 0.016 15.4 1.4 5.8 7.1 0.4 2.4 2 0 0 2 2 2 0 p25-alpha FDX-ACB PF03147.14 ETO11733.1 - 0.047 14.1 0.6 2.1 8.8 0.0 2.9 2 1 0 2 2 2 0 Ferredoxin-fold anticodon binding domain PMBR PF09373.10 ETO11733.1 - 0.064 13.4 0.5 5.9 7.2 0.0 3.9 5 0 0 5 5 5 0 Pseudomurein-binding repeat Kelch_6 PF13964.6 ETO11734.1 - 7.7e-05 22.8 0.4 0.2 12.0 0.0 3.8 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO11734.1 - 0.00075 19.0 2.4 0.0037 16.8 0.0 3.2 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO11734.1 - 0.00099 19.0 2.4 0.095 12.7 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO11734.1 - 0.0086 16.1 0.9 0.27 11.2 0.0 3.0 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO11734.1 - 0.14 12.5 0.2 0.92 9.9 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Serpin PF00079.20 ETO11736.1 - 3.9e-06 26.4 0.0 7.8e-06 25.4 0.0 1.4 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF2829 PF11195.8 ETO11736.1 - 0.097 12.9 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2829) Ion_trans PF00520.31 ETO11737.1 - 1.4e-19 70.3 49.6 2.8e-18 66.1 22.6 2.3 2 0 0 2 2 2 2 Ion transport protein EF-hand_7 PF13499.6 ETO11737.1 - 0.00039 20.8 4.1 0.98 9.9 0.4 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO11737.1 - 0.00074 19.3 2.3 0.44 10.6 0.7 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO11737.1 - 0.0044 16.5 2.9 0.65 9.7 0.8 2.7 2 0 0 2 2 2 2 EF hand Atrophin-1 PF03154.15 ETO11737.1 - 0.05 11.9 1.6 0.084 11.2 1.6 1.3 1 0 0 1 1 1 0 Atrophin-1 family COX6B PF02297.17 ETO11737.1 - 0.1 12.9 3.0 0.24 11.7 3.0 1.7 1 1 0 1 1 1 0 Cytochrome oxidase c subunit VIb FANCL_C PF11793.8 ETO11737.1 - 0.18 12.0 0.3 0.97 9.7 0.2 2.2 2 0 0 2 2 2 0 FANCL C-terminal domain CobT PF06213.12 ETO11737.1 - 0.69 9.2 8.9 0.61 9.4 7.5 1.5 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT DUF3306 PF11748.8 ETO11737.1 - 2.5 9.0 8.2 14 6.6 8.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3306) Roughex PF06020.11 ETO11737.1 - 5.5 6.0 8.6 9.2 5.3 8.6 1.2 1 0 0 1 1 1 0 Drosophila roughex protein EF1G PF00647.19 ETO11738.1 - 0.29 11.2 8.2 1.1 9.3 0.4 3.3 3 0 0 3 3 3 0 Elongation factor 1 gamma, conserved domain WD40 PF00400.32 ETO11740.1 - 1.8e-17 63.4 11.6 2.9e-06 27.9 0.0 4.1 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11740.1 - 7.2e-06 26.2 0.5 0.085 13.2 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11740.1 - 0.0003 19.6 0.8 2.4 6.7 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11740.1 - 0.0046 16.3 1.0 0.021 14.2 0.4 2.0 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO11740.1 - 0.016 15.1 0.3 0.78 9.6 0.1 2.5 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF5046 PF16465.5 ETO11740.1 - 0.033 13.7 0.0 0.049 13.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5046) ABC_transp_aux PF09822.9 ETO11744.1 - 0.019 14.4 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 ABC-type uncharacterized transport system DUF4350 PF14258.6 ETO11744.1 - 0.13 12.7 0.0 0.43 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4350) Peptidase_S8 PF00082.22 ETO11745.1 - 2.6e-12 46.6 0.0 6.3e-12 45.4 0.0 1.5 1 1 0 1 1 1 1 Subtilase family LAP1C PF05609.12 ETO11746.1 - 0.79 8.7 17.3 0.95 8.5 17.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 ETO11746.1 - 1.5 7.3 18.1 1.5 7.3 18.1 1.1 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO11746.1 - 8.6 4.6 15.9 9.7 4.4 15.9 1.2 1 0 0 1 1 1 0 Menin NMT_C PF02799.15 ETO11747.1 - 1.1e-72 244.0 1.1 1.7e-72 243.3 1.1 1.2 1 0 0 1 1 1 1 Myristoyl-CoA:protein N-myristoyltransferase, C-terminal domain NMT PF01233.19 ETO11747.1 - 5.8e-33 114.0 2.3 5.5e-28 97.8 0.7 2.4 1 1 1 2 2 2 2 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain CDC27 PF09507.10 ETO11747.1 - 0.41 10.0 10.1 0.56 9.5 10.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TrkA_C PF02080.21 ETO11748.1 - 1.5e-07 31.1 0.0 3.9e-06 26.6 0.0 2.9 2 1 1 3 3 3 1 TrkA-C domain RcbX PF02341.15 ETO11748.1 - 0.057 13.7 0.0 0.15 12.3 0.0 1.7 1 0 0 1 1 1 0 RbcX protein Hemerythrin PF01814.23 ETO11750.1 - 0.0097 16.5 0.2 0.013 16.1 0.2 1.2 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain vATP-synt_E PF01991.18 ETO11750.1 - 0.042 13.3 0.1 0.55 9.6 0.0 2.0 2 0 0 2 2 2 0 ATP synthase (E/31 kDa) subunit Hemerythrin PF01814.23 ETO11751.1 - 7.5e-07 29.8 0.5 9.8e-07 29.4 0.5 1.1 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF3465 PF11948.8 ETO11752.1 - 0.015 15.2 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3465) DUF3888 PF13027.6 ETO11752.1 - 0.024 15.1 0.2 0.042 14.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3888) DUF3853 PF12964.7 ETO11753.1 - 0.048 13.8 0.1 0.088 13.0 0.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3853) MCR_beta PF02241.18 ETO11753.1 - 0.17 11.4 0.2 0.21 11.2 0.2 1.1 1 0 0 1 1 1 0 Methyl-coenzyme M reductase beta subunit, C-terminal domain WD40 PF00400.32 ETO11755.1 - 1.1e-37 127.3 19.6 2.3e-07 31.4 0.8 7.1 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11755.1 - 2.8e-14 53.2 0.3 0.016 15.5 0.0 5.8 4 3 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11755.1 - 8.2e-08 31.3 4.3 0.0018 17.0 0.3 3.5 2 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11755.1 - 2.5e-05 23.8 3.3 0.62 9.3 0.1 3.8 2 2 2 4 4 4 3 WD40-like domain Josephin PF02099.17 ETO11756.1 - 6.3e-13 49.2 0.0 1e-12 48.5 0.0 1.4 1 1 0 1 1 1 1 Josephin Fcf1 PF04900.12 ETO11757.1 - 4.6e-30 103.9 1.4 4.6e-30 103.9 1.4 1.5 2 0 0 2 2 2 1 Fcf1 PIN_9 PF18477.1 ETO11757.1 - 7.8e-11 42.3 0.0 1.7e-10 41.2 0.0 1.6 2 0 0 2 2 2 1 PIN like domain PIN PF01850.21 ETO11757.1 - 0.031 14.8 1.1 4.5 7.8 0.1 2.2 1 1 1 2 2 2 0 PIN domain NOA36 PF06524.12 ETO11759.1 - 6.3e-06 25.7 13.2 2e-05 24.1 13.2 1.9 1 0 0 1 1 1 1 NOA36 protein SGL PF08450.12 ETO11760.1 - 2.6e-06 27.2 0.0 5.2e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 ETO11760.1 - 0.0088 16.2 0.0 0.045 13.9 0.0 2.1 2 0 0 2 2 2 1 Strictosidine synthase Arylesterase PF01731.20 ETO11760.1 - 0.072 13.3 0.4 0.91 9.8 0.6 2.6 2 1 0 2 2 2 0 Arylesterase Alg6_Alg8 PF03155.15 ETO11761.1 - 3.3e-135 451.8 10.4 4.6e-135 451.3 10.4 1.1 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family WD40 PF00400.32 ETO11762.1 - 3.9e-18 65.5 21.7 8.7e-06 26.4 0.4 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11762.1 - 1.8e-05 24.9 0.9 0.004 17.4 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11762.1 - 0.0026 17.1 8.5 0.01 15.2 7.3 2.3 1 1 1 2 2 2 1 WD40-like domain WD40 PF00400.32 ETO11763.1 - 8e-13 48.7 4.3 1.4e-07 32.1 0.5 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO11763.1 - 0.00013 20.8 0.3 0.00014 20.7 0.3 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11763.1 - 0.0012 18.2 2.7 0.0014 18.0 2.7 1.2 1 0 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO11763.1 - 0.0054 17.0 0.0 0.0093 16.3 0.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain ALS2CR8 PF15299.6 ETO11763.1 - 0.058 13.3 0.0 0.065 13.1 0.0 1.1 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 Kelch_6 PF13964.6 ETO11765.1 - 0.00068 19.8 1.0 0.013 15.8 0.2 3.2 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO11765.1 - 0.0014 18.6 0.4 0.0088 16.0 0.2 2.5 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO11765.1 - 0.013 15.0 0.3 0.4 10.3 0.0 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO11765.1 - 0.045 13.8 1.1 0.45 10.6 0.0 3.1 4 1 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO11765.1 - 0.084 13.2 0.0 1.1 9.7 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain WD40 PF00400.32 ETO11766.1 - 3.4e-08 34.0 13.8 4.1e-05 24.3 1.1 3.8 3 2 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11766.1 - 0.0019 18.4 0.4 1.2 9.5 0.1 3.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11766.1 - 0.02 13.5 0.3 2.1 6.9 0.0 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 BHD_1 PF10403.9 ETO11766.1 - 0.14 12.0 0.8 2.6 7.9 0.2 2.3 2 0 0 2 2 2 0 Rad4 beta-hairpin domain 1 WD40 PF00400.32 ETO11767.1 - 4.4e-20 71.6 14.5 8.7e-07 29.6 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11767.1 - 3.5e-09 35.9 0.8 0.002 16.8 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11767.1 - 2.7e-07 30.8 0.1 0.049 13.9 0.0 2.8 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11767.1 - 0.0014 18.0 1.7 0.015 14.6 1.2 2.2 1 1 1 2 2 2 1 WD40-like domain UCH PF00443.29 ETO11768.1 - 3.3e-09 36.6 0.2 3.3e-09 36.6 0.2 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO11768.1 - 9.7e-06 25.4 0.1 9.7e-06 25.4 0.1 2.7 2 1 1 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase TPR_12 PF13424.6 ETO11770.1 - 0.033 14.5 4.0 14 6.0 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-HIT PF04438.16 ETO11770.1 - 1.2 9.1 7.3 0.17 11.8 1.1 2.6 2 0 0 2 2 2 0 HIT zinc finger WD40 PF00400.32 ETO11771.1 - 3.4e-14 53.0 10.6 0.00078 20.2 1.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat WD40_like PF17005.5 ETO11771.1 - 0.0075 15.6 4.6 0.051 12.9 0.1 3.1 1 1 2 3 3 3 2 WD40-like domain Rhodanese PF00581.20 ETO11773.1 - 1.7e-14 54.3 5.0 8.2e-07 29.5 0.0 3.0 3 0 0 3 3 3 2 Rhodanese-like domain Kelch_2 PF07646.15 ETO11774.1 - 7.1e-05 22.6 0.2 0.001 18.9 0.1 2.4 2 1 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO11774.1 - 0.0001 22.5 0.1 0.042 14.1 0.3 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO11774.1 - 0.0061 16.8 0.1 0.032 14.5 0.1 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO11774.1 - 0.014 14.9 0.2 0.031 13.9 0.2 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_5 PF13854.6 ETO11774.1 - 0.019 14.9 0.4 0.033 14.2 0.4 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_4 PF13418.6 ETO11774.1 - 0.07 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 Galactose oxidase, central domain NYD-SP28_assoc PF14775.6 ETO11774.1 - 0.082 13.0 0.2 0.16 12.1 0.0 1.6 1 1 1 2 2 2 0 Sperm tail C-terminal domain WD40 PF00400.32 ETO11775.1 - 2.4e-31 107.3 12.8 1.9e-09 38.0 0.1 5.0 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11775.1 - 2.3e-13 50.3 0.2 0.00016 21.9 0.0 3.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11775.1 - 1.9e-06 26.8 0.2 0.062 11.9 0.0 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO11775.1 - 2.7e-05 23.3 0.2 0.4 9.6 0.1 3.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11775.1 - 0.00086 18.7 1.5 0.0059 16.0 0.8 2.3 1 1 1 2 2 2 1 WD40-like domain PD40 PF07676.12 ETO11775.1 - 0.037 14.0 1.5 2.5 8.1 0.2 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO11776.1 - 1.5e-09 38.3 1.2 0.00023 21.9 0.1 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO11776.1 - 0.016 13.9 0.0 0.85 8.2 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 NOP5NT PF08156.13 ETO11777.1 - 1.8e-17 63.4 1.7 4.9e-17 62.1 1.7 1.8 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Lipase_GDSL PF00657.22 ETO11777.1 - 0.33 10.9 2.4 0.55 10.2 2.1 1.7 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Nop PF01798.18 ETO11778.1 - 3.1e-21 75.9 1.1 3.9e-21 75.6 1.1 1.1 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Nop PF01798.18 ETO11779.1 - 1.2e-35 123.1 0.1 1.2e-35 123.1 0.1 2.1 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin CT47 PF15623.6 ETO11779.1 - 3.4 7.4 24.3 0.26 11.1 19.4 1.6 2 0 0 2 2 2 0 Cancer/testis gene family 47 LRAT PF04970.13 ETO11780.1 - 0.011 16.0 0.2 0.018 15.4 0.2 1.4 1 1 0 1 1 1 0 Lecithin retinol acyltransferase WD40 PF00400.32 ETO11782.1 - 0.00019 22.2 5.3 0.0002 22.1 0.3 3.2 3 2 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 ETO11785.1 - 4.1e-56 185.7 15.9 3.9e-09 37.0 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11785.1 - 9.7e-20 70.7 0.8 0.014 15.7 0.0 6.9 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11785.1 - 1.1e-08 34.2 2.6 0.62 8.6 0.0 6.0 1 1 6 7 7 7 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO11785.1 - 9.5e-08 31.4 4.2 0.02 13.9 0.7 4.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11785.1 - 4.9e-06 26.1 0.3 0.035 13.4 0.0 3.4 1 1 2 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO11785.1 - 0.00016 20.3 0.5 0.08 11.5 0.1 3.0 1 1 3 4 4 4 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO11785.1 - 0.00074 19.2 0.0 0.011 15.4 0.0 2.5 1 1 0 1 1 1 1 PQQ-like domain PD40 PF07676.12 ETO11785.1 - 0.0011 18.8 1.2 4.6 7.3 0.0 4.2 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO11785.1 - 0.0031 17.4 0.0 45 4.2 0.0 5.1 6 0 0 6 6 6 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO11785.1 - 0.0036 16.3 0.4 2.7 6.8 0.1 3.6 2 2 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain BBS2_Mid PF14783.6 ETO11785.1 - 0.01 15.9 3.4 8.5 6.5 0.1 4.9 2 1 4 6 6 6 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO11786.1 - 1.1e-38 130.5 7.1 6e-11 42.7 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11786.1 - 1.2e-14 54.3 0.2 0.00032 21.0 0.0 4.6 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11786.1 - 4.5e-11 42.3 0.0 0.03 13.3 0.0 4.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO11786.1 - 2.2e-08 34.2 0.2 1.4e-05 25.1 0.2 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO11786.1 - 6e-07 29.1 0.1 0.0043 16.4 0.0 2.1 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO11786.1 - 9.1e-06 25.5 3.6 4.4 7.4 0.1 5.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO11786.1 - 1.2e-05 24.2 1.8 0.25 9.9 0.0 3.8 1 1 3 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO11786.1 - 3.7e-05 22.8 0.3 0.17 10.8 0.1 3.0 1 1 2 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Coatomer_WDAD PF04053.14 ETO11786.1 - 0.00022 20.4 0.4 0.0037 16.4 0.2 2.0 1 1 1 2 2 2 2 Coatomer WD associated region DUF5570 PF17731.1 ETO11786.1 - 0.00085 19.4 0.2 4.1 7.5 0.0 3.8 1 1 3 4 4 4 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO11786.1 - 0.001 17.7 0.2 0.73 8.3 0.0 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO11786.1 - 0.0032 16.3 2.2 0.6 8.8 0.1 3.3 1 1 3 4 4 4 1 Nup133 N terminal like DUF3748 PF12566.8 ETO11786.1 - 0.026 14.5 0.0 19 5.2 0.0 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF3748) PQQ PF01011.21 ETO11786.1 - 0.042 13.8 0.7 0.54 10.3 0.1 3.1 4 0 0 4 4 4 0 PQQ enzyme repeat Utp8 PF10395.9 ETO11786.1 - 0.071 11.6 0.0 0.28 9.6 0.0 1.7 1 1 1 2 2 2 0 Utp8 family Proteasome_A_N PF10584.9 ETO11786.1 - 0.15 11.8 3.6 16 5.3 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature VWA_2 PF13519.6 ETO11788.1 - 0.0012 19.4 0.0 0.0021 18.6 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Peptidase_C25 PF01364.18 ETO11788.1 - 0.0047 16.2 0.0 0.0069 15.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family C25 Chlorosome_CsmC PF11098.8 ETO11788.1 - 0.12 12.3 0.1 0.4 10.7 0.0 1.8 2 0 0 2 2 2 0 Chlorosome envelope protein C WD40 PF00400.32 ETO11790.1 - 8.2e-17 61.3 11.0 1.7e-05 25.5 0.1 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11790.1 - 0.00014 22.0 0.7 0.54 10.6 0.1 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11790.1 - 0.015 14.0 1.3 4.3 5.9 0.0 2.9 1 1 2 3 3 3 0 Nucleoporin Nup120/160 CUE PF02845.16 ETO11791.1 - 0.015 15.0 0.0 1.1 9.0 0.0 2.7 3 0 0 3 3 3 0 CUE domain HeLo PF14479.6 ETO11791.1 - 0.064 13.1 0.8 0.088 12.6 0.8 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation F-box-like PF12937.7 ETO11793.1 - 0.058 13.3 0.3 0.12 12.3 0.3 1.6 1 0 0 1 1 1 0 F-box-like LRR_4 PF12799.7 ETO11793.1 - 0.11 12.9 7.1 0.19 12.2 0.4 3.5 3 1 1 4 4 4 0 Leucine Rich repeats (2 copies) ACDC PF14733.6 ETO11793.1 - 0.25 11.7 2.4 0.49 10.7 0.6 2.4 2 0 0 2 2 2 0 AP2-coincident C-terminal Peptidase_C14 PF00656.22 ETO11794.1 - 3.8e-06 27.1 0.1 4.5e-06 26.8 0.1 1.1 1 0 0 1 1 1 1 Caspase domain ComC PF03047.14 ETO11795.1 - 0.15 11.9 3.1 1.2 9.0 0.0 2.9 3 0 0 3 3 3 0 COMC family WD40 PF00400.32 ETO11796.1 - 1.1e-27 95.7 3.7 8.6e-09 35.9 0.1 7.4 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11796.1 - 9.7e-13 48.2 0.5 0.0018 18.6 0.0 5.8 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11796.1 - 2.8e-05 23.2 0.1 0.71 8.8 0.0 3.5 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_5 PF13854.6 ETO11796.1 - 0.054 13.5 5.9 1.9 8.6 0.2 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO11796.1 - 0.078 13.3 4.7 8 6.9 0.1 3.7 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ETO11796.1 - 0.17 12.0 0.4 11 6.1 0.1 2.9 2 0 0 2 2 2 0 Galactose oxidase, central domain PD40 PF07676.12 ETO11796.1 - 0.26 11.3 3.8 2 8.5 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Kelch_2 PF07646.15 ETO11796.1 - 0.4 10.7 3.5 47 4.2 0.1 4.4 5 0 0 5 5 5 0 Kelch motif NFRKB_winged PF14465.6 ETO11796.1 - 0.8 9.9 3.6 22 5.3 0.3 2.9 2 0 0 2 2 2 0 NFRKB Winged Helix-like CENP-P PF13096.6 ETO11797.1 - 0.17 11.6 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P CDC45 PF02724.14 ETO11798.1 - 0.0031 15.9 21.4 0.0031 15.9 21.4 3.1 1 1 1 3 3 3 1 CDC45-like protein TetR_C_19 PF17924.1 ETO11800.1 - 0.023 15.3 0.5 0.081 13.5 0.3 2.0 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain MRP-L46 PF11788.8 ETO11800.1 - 1.2 9.9 4.1 0.51 11.1 1.2 1.9 2 1 0 2 2 2 0 39S mitochondrial ribosomal protein L46 Histone PF00125.24 ETO11801.1 - 3.9e-47 159.9 6.0 6.2e-46 156.0 2.4 2.0 1 1 1 2 2 2 2 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ETO11801.1 - 1e-05 25.8 0.0 1.7e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ETO11801.1 - 9.7e-05 22.4 0.1 0.0002 21.4 0.1 1.5 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 ETO11801.1 - 0.011 16.0 0.0 0.024 14.9 0.0 1.6 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Bromo_TP PF07524.13 ETO11801.1 - 0.081 12.9 0.1 0.18 11.8 0.1 1.6 1 1 0 1 1 1 0 Bromodomain associated PAF PF15715.5 ETO11801.1 - 2.1 8.9 8.2 0.36 11.4 1.5 2.1 1 1 0 2 2 2 0 PCNA-associated factor histone like domain DUF5373 PF17343.2 ETO11802.1 - 0.093 12.6 1.9 0.31 10.9 0.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5373) ATP-synt_Z PF16594.5 ETO11802.1 - 4.2 6.9 8.7 3.1 7.4 5.5 2.4 2 1 0 2 2 2 0 Putative AtpZ or ATP-synthase-associated UBA PF00627.31 ETO11803.1 - 0.0038 17.1 0.1 0.0061 16.4 0.1 1.3 1 0 0 1 1 1 1 UBA/TS-N domain WD40 PF00400.32 ETO11805.1 - 2.8e-52 173.5 19.8 2e-08 34.8 0.5 7.4 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11805.1 - 3.6e-21 75.3 2.4 0.00038 20.7 0.0 6.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11805.1 - 4.7e-14 52.1 0.3 0.15 11.0 0.0 6.2 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO11805.1 - 9.9e-09 34.9 4.5 1.4 8.9 0.0 6.7 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO11805.1 - 1.4e-06 27.9 0.1 0.12 11.7 0.0 3.3 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO11805.1 - 8.5e-05 21.4 4.4 0.12 11.0 0.0 4.0 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETO11805.1 - 0.00033 20.2 5.5 26 4.6 0.0 6.7 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Coatomer_WDAD PF04053.14 ETO11805.1 - 0.00035 19.8 0.1 0.00099 18.3 0.1 1.6 2 0 0 2 2 2 1 Coatomer WD associated region DUF5570 PF17731.1 ETO11805.1 - 0.0024 18.0 1.5 38 4.4 0.1 4.1 2 1 1 4 4 4 0 Family of unknown function (DUF5570) DPPIV_N PF00930.21 ETO11805.1 - 0.0086 14.9 0.0 3.9 6.1 0.0 3.5 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_M44 PF03410.13 ETO11805.1 - 0.013 14.1 1.9 0.016 13.8 1.9 1.1 1 0 0 1 1 1 0 Metallopeptidase from vaccinia pox DUF3188 PF11384.8 ETO11806.1 - 0.046 13.4 0.0 0.093 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Ribosomal_L36e PF01158.18 ETO11807.1 - 2.4e-18 66.1 10.9 7.9e-16 58.1 4.7 2.5 1 1 1 2 2 2 2 Ribosomal protein L36e LAMTOR5 PF16672.5 ETO11808.1 - 1.2e-06 28.3 0.0 2.9e-06 27.1 0.0 1.6 1 0 0 1 1 1 1 Ragulator complex protein LAMTOR5 PBP1_TM PF14812.6 ETO11808.1 - 0.14 12.5 3.3 0.18 12.2 1.2 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WD40 PF00400.32 ETO11810.1 - 2.7e-35 119.8 19.9 1.9e-07 31.7 0.4 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11810.1 - 4e-13 49.5 1.8 0.024 14.9 0.0 5.7 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11810.1 - 8.4e-08 31.3 2.6 0.078 11.6 0.1 4.2 2 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11810.1 - 6.8e-05 22.3 5.0 0.87 8.9 0.1 4.4 3 2 2 5 5 5 4 WD40-like domain HARP PF07443.13 ETO11810.1 - 0.03 13.9 1.9 9.6 5.9 0.1 3.8 4 0 0 4 4 4 0 HepA-related protein (HARP) DUF4979 PF16351.5 ETO11810.1 - 0.13 12.5 0.8 21 5.3 0.1 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4979) DUF3294 PF07957.11 ETO11811.1 - 0.018 14.8 0.7 0.032 14.0 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3294) PKcGMP_CC PF16808.5 ETO11811.1 - 0.031 14.1 0.8 1.7 8.6 0.2 2.7 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase ABC_tran_CTD PF16326.5 ETO11815.1 - 0.024 14.9 7.7 0.024 14.9 7.7 3.5 1 1 2 3 3 3 0 ABC transporter C-terminal domain Ax_dynein_light PF10211.9 ETO11815.1 - 0.3 11.0 36.9 0.48 10.3 15.9 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain FAM76 PF16046.5 ETO11815.1 - 0.63 9.3 25.3 0.76 9.1 25.3 1.1 1 0 0 1 1 1 0 FAM76 protein ApoO PF09769.9 ETO11815.1 - 1.4 8.9 4.8 5.6 6.9 4.1 2.3 1 1 0 1 1 1 0 Apolipoprotein O ERM PF00769.19 ETO11815.1 - 2.3 8.0 40.4 2.7 7.7 40.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family AAA_11 PF13086.6 ETO11815.1 - 3.4 7.4 18.3 5.4 6.7 18.3 1.3 1 0 0 1 1 1 0 AAA domain FlaC_arch PF05377.11 ETO11815.1 - 4.4 7.8 12.4 0.93 9.9 0.7 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Hid1 PF12722.7 ETO11816.1 - 0.082 11.0 7.4 0.1 10.7 7.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM163 PF15069.6 ETO11816.1 - 1.6 9.1 4.3 1.4 9.3 2.7 1.7 1 1 0 2 2 2 0 FAM163 family CagA PF03507.13 ETO11817.1 - 0.043 13.7 0.1 0.09 12.7 0.1 1.6 1 0 0 1 1 1 0 CagA exotoxin Kelch_6 PF13964.6 ETO11819.1 - 1.3e-05 25.3 0.0 0.021 15.1 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO11819.1 - 0.0013 18.3 0.0 0.0064 16.0 0.0 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO11819.1 - 0.0028 17.6 0.4 0.11 12.5 0.1 2.4 2 1 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO11819.1 - 0.0085 16.1 0.0 0.65 10.0 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO11819.1 - 0.036 14.1 0.2 0.36 10.9 0.0 2.5 2 1 0 2 2 2 0 Kelch motif DUF5537 PF17690.1 ETO11821.1 - 0.049 13.3 0.1 0.077 12.7 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5537) Peroxin-13_N PF04088.13 ETO11821.1 - 3.8 7.8 6.2 0.62 10.3 1.4 2.0 1 1 1 2 2 2 0 Peroxin 13, N-terminal region Pkinase PF00069.25 ETO11823.1 - 7.5e-32 110.7 0.2 1.2e-17 64.1 0.0 3.3 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11823.1 - 2.1e-22 79.7 0.3 1.3e-13 50.9 0.0 3.2 3 0 0 3 3 3 3 Protein tyrosine kinase Kdo PF06293.14 ETO11823.1 - 0.14 11.5 0.1 0.27 10.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family DNA_pol_phi PF04931.13 ETO11823.1 - 1.6 6.8 11.8 3.4 5.7 11.8 1.4 1 0 0 1 1 1 0 DNA polymerase phi Ank_2 PF12796.7 ETO11824.1 - 0.0032 18.0 0.1 0.024 15.2 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) WD40 PF00400.32 ETO11828.1 - 1.9e-35 120.3 22.6 2.1e-05 25.1 0.3 7.5 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO11828.1 - 6.8e-10 38.2 5.0 0.013 14.2 0.0 5.1 2 1 1 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11828.1 - 3.7e-09 36.7 1.9 0.5 10.7 0.0 5.9 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain HAP1_N PF04849.13 ETO11828.1 - 0.0061 15.8 8.1 0.0092 15.2 8.1 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region ALMT PF11744.8 ETO11828.1 - 4.3 6.0 7.1 6.1 5.6 7.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter TMPIT PF07851.13 ETO11828.1 - 5.7 6.1 8.4 7.8 5.6 8.4 1.2 1 0 0 1 1 1 0 TMPIT-like protein WD40 PF00400.32 ETO11829.1 - 2.2e-23 82.1 16.3 3.4e-08 34.0 1.0 4.5 3 1 1 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO11829.1 - 5.7e-07 28.6 1.7 0.018 13.7 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO11829.1 - 2.2e-05 23.9 3.7 0.036 13.4 0.1 2.5 2 1 1 3 3 3 2 WD40-like domain ANAPC4_WD40 PF12894.7 ETO11829.1 - 2.7e-05 24.4 0.1 0.063 13.6 0.0 3.2 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain OSK PF17182.4 ETO11829.1 - 1.1 8.5 4.7 9.7 5.4 0.1 2.1 2 0 0 2 2 2 0 OSK domain Phytochelatin PF05023.14 ETO11830.1 - 1.8e-38 131.9 0.0 3.1e-38 131.1 0.0 1.3 1 0 0 1 1 1 1 Phytochelatin synthase Peptidase_C39_2 PF13529.6 ETO11830.1 - 0.043 14.4 0.0 0.14 12.7 0.0 1.8 2 0 0 2 2 2 0 Peptidase_C39 like family M16C_assoc PF08367.11 ETO11831.1 - 9.6e-39 133.0 7.0 3.6e-38 131.1 7.0 1.9 1 1 0 1 1 1 1 Peptidase M16C associated Peptidase_M16_C PF05193.21 ETO11831.1 - 7.7e-13 48.8 0.0 2.2e-10 40.8 0.0 3.2 3 0 0 3 3 3 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ETO11831.1 - 1.8e-11 44.2 1.3 3.5e-10 40.1 0.1 2.7 2 0 0 2 2 2 1 Insulinase (Peptidase family M16) DUF3384 PF11864.8 ETO11831.1 - 0.00021 20.4 0.5 0.00038 19.5 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3384) Flagellin_IN PF07196.13 ETO11831.1 - 0.091 13.0 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 Flagellin hook IN motif WD40 PF00400.32 ETO11832.1 - 4.1e-65 214.1 25.6 1e-11 45.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11832.1 - 7.9e-21 74.2 2.5 0.0011 19.2 0.0 7.0 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11832.1 - 7.8e-13 48.1 0.3 0.29 10.1 0.0 6.2 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO11832.1 - 1.3e-10 41.2 1.8 0.00056 19.3 0.0 3.3 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO11832.1 - 6.6e-08 31.6 4.7 0.97 8.0 0.0 5.8 2 1 3 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO11832.1 - 7.6e-05 22.5 6.4 7.4 6.6 0.0 5.7 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 ETO11832.1 - 0.0019 17.7 0.0 0.42 10.0 0.0 2.4 2 1 0 2 2 2 2 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 ETO11832.1 - 0.003 16.1 0.7 4.5 5.7 0.0 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO11832.1 - 0.0059 15.4 8.7 0.14 10.9 0.7 3.8 2 1 2 4 4 4 2 Nup133 N terminal like DPPIV_N PF00930.21 ETO11832.1 - 0.0065 15.3 0.7 1.8 7.3 0.1 3.8 1 1 1 2 2 2 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO11832.1 - 0.027 14.5 0.5 19 5.3 0.0 3.8 2 1 2 4 4 4 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO11832.1 - 4.2 7.2 9.7 31 4.4 0.0 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Peptidase_C48 PF02902.19 ETO11833.1 - 6.1e-20 72.0 10.4 1e-19 71.2 8.1 2.6 2 1 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain SDA1 PF05285.12 ETO11833.1 - 3.7 6.9 33.2 0.58 9.5 25.5 2.3 2 0 0 2 2 2 0 SDA1 Actin PF00022.19 ETO11834.1 - 4.7e-65 219.8 0.0 1.1e-46 159.3 0.0 2.7 2 1 0 2 2 2 2 Actin MreB_Mbl PF06723.13 ETO11834.1 - 0.25 10.1 0.0 0.86 8.4 0.0 1.9 1 1 0 1 1 1 0 MreB/Mbl protein Exo70 PF03081.15 ETO11835.1 - 2.7e-55 188.0 6.1 3.5e-55 187.6 6.1 1.1 1 0 0 1 1 1 1 Exo70 exocyst complex subunit DBP10CT PF08147.12 ETO11838.1 - 0.037 14.3 0.0 0.037 14.3 0.0 1.9 2 0 0 2 2 2 0 DBP10CT (NUC160) domain Glyco_hydro_31 PF01055.26 ETO11839.1 - 2.4e-17 63.3 0.2 4.8e-17 62.3 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF4968 PF16338.5 ETO11839.1 - 0.0002 21.6 0.2 0.00064 20.0 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4968) Gal_mutarotas_2 PF13802.6 ETO11839.1 - 0.01 16.1 0.9 0.089 13.1 0.9 2.4 1 1 0 1 1 1 0 Galactose mutarotase-like Glyco_hydro_31 PF01055.26 ETO11840.1 - 5e-72 243.5 2.3 6.3e-72 243.2 2.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 ETO11840.1 - 2.3e-11 43.8 0.0 4e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) ANTH PF07651.16 ETO11841.1 - 0.097 11.6 2.0 0.1 11.6 0.7 1.7 2 0 0 2 2 2 0 ANTH domain Nop14 PF04147.12 ETO11841.1 - 1.3 7.2 21.5 1.5 6.9 21.5 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIA PF03153.13 ETO11841.1 - 3.4 7.6 27.5 4.5 7.2 27.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 ETO11841.1 - 4.3 5.8 14.1 5.3 5.5 14.1 1.0 1 0 0 1 1 1 0 Macoilin family SAS-6_N PF16531.5 ETO11842.1 - 8.3e-16 58.4 0.7 2.3e-15 56.9 0.7 1.8 1 0 0 1 1 1 1 Centriolar protein SAS N-terminal TMEM154 PF15102.6 ETO11842.1 - 0.0062 16.5 0.0 0.0087 16.0 0.0 1.3 1 0 0 1 1 1 1 TMEM154 protein family LRR_4 PF12799.7 ETO11843.1 - 5e-05 23.6 8.9 0.00078 19.8 5.0 3.1 1 1 2 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO11843.1 - 0.0055 16.4 5.9 0.38 10.5 6.1 2.8 1 1 0 1 1 1 1 Leucine rich repeat LRR_6 PF13516.6 ETO11843.1 - 0.0087 16.0 4.1 0.12 12.5 0.1 3.2 3 0 0 3 3 3 1 Leucine Rich repeat LRR_1 PF00560.33 ETO11843.1 - 0.35 11.6 11.3 17 6.5 0.5 5.3 3 1 0 3 3 3 0 Leucine Rich Repeat LRR_8 PF13855.6 ETO11844.1 - 4.2e-14 52.1 42.1 1.4e-05 24.7 0.2 7.3 5 2 1 8 8 8 4 Leucine rich repeat LRR_4 PF12799.7 ETO11844.1 - 1.3e-10 41.4 47.5 6.9e-05 23.1 5.6 9.3 4 3 8 12 12 12 8 Leucine Rich repeats (2 copies) Bac_export_2 PF01312.19 ETO11844.1 - 5.3e-05 22.6 0.4 5.3e-05 22.6 0.4 2.6 2 1 0 3 3 3 1 FlhB HrpN YscU SpaS Family Radical_SAM_C PF16199.5 ETO11844.1 - 0.084 12.9 0.0 0.26 11.3 0.0 1.8 1 0 0 1 1 1 0 Radical_SAM C-terminal domain LRR_1 PF00560.33 ETO11844.1 - 1.3 9.8 44.7 4.7 8.2 0.7 11.9 12 2 1 13 13 13 0 Leucine Rich Repeat Ribosomal_L22 PF00237.19 ETO11846.1 - 1.3e-16 60.7 0.1 1.6e-16 60.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e DUF2663 PF10864.8 ETO11847.1 - 0.0044 17.4 2.3 0.0091 16.4 2.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2663) LIME1 PF15332.6 ETO11848.1 - 0.32 10.6 5.6 0.4 10.3 5.6 1.1 1 0 0 1 1 1 0 Lck-interacting transmembrane adapter 1 ATF7IP_BD PF16788.5 ETO11848.1 - 5.4 7.0 13.9 10 6.1 13.9 1.4 1 0 0 1 1 1 0 ATF-interacting protein binding domain DNA_pol_phi PF04931.13 ETO11851.1 - 0.59 8.2 10.5 0.59 8.2 10.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi TLP-20 PF06088.11 ETO11851.1 - 0.98 9.3 8.5 1.3 8.9 8.5 1.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CDC45 PF02724.14 ETO11851.1 - 1.2 7.4 7.6 1.2 7.3 7.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Di19_C PF14571.6 ETO11851.1 - 1.2 9.7 5.9 0.3 11.7 1.6 2.0 2 1 0 2 2 2 0 Stress-induced protein Di19, C-terminal FAM176 PF14851.6 ETO11851.1 - 1.9 8.2 7.7 1.4 8.6 6.7 1.4 1 1 0 1 1 1 0 FAM176 family DUF1672 PF07901.11 ETO11852.1 - 0.076 12.3 0.8 1.2 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1672) PRCH PF03967.13 ETO11852.1 - 0.15 12.3 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Photosynthetic reaction centre, H-chain N-terminal region DUF2921 PF11145.8 ETO11853.1 - 1.6 6.4 6.3 1.5 6.5 6.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) FliT PF05400.13 ETO11855.1 - 0.7 10.7 2.8 11 7.0 0.7 2.9 3 0 0 3 3 3 0 Flagellar protein FliT Kelch_4 PF13418.6 ETO11856.1 - 0.00018 21.4 0.0 0.0015 18.5 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO11856.1 - 0.014 15.4 1.8 0.29 11.2 0.2 3.6 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO11856.1 - 0.044 14.1 1.9 4.2 7.8 0.0 3.4 4 0 0 4 4 4 0 Kelch motif ATP-synt_8 PF00895.20 ETO11856.1 - 0.06 13.8 0.8 0.06 13.8 0.8 3.3 3 0 0 3 3 3 0 ATP synthase protein 8 Kelch_3 PF13415.6 ETO11856.1 - 0.081 13.2 0.0 0.23 11.8 0.0 1.8 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO11856.1 - 1.1 8.9 5.1 0.38 10.4 0.1 2.7 4 0 0 4 4 4 0 Kelch motif zf-TRAF PF02176.18 ETO11857.1 - 0.0001 22.9 5.9 0.0001 22.9 5.9 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger WD40 PF00400.32 ETO11858.1 - 5.7e-34 115.6 11.3 4.2e-09 36.9 0.1 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11858.1 - 2.8e-14 53.2 5.1 0.01 16.1 0.1 6.9 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.6 ETO11858.1 - 2.7e-07 30.5 0.1 8.8e-07 28.8 0.1 1.9 1 0 0 1 1 1 1 Galactose oxidase, central domain Ge1_WD40 PF16529.5 ETO11858.1 - 4.9e-07 29.0 3.5 0.14 11.1 0.0 5.0 2 1 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_1 PF01344.25 ETO11858.1 - 2.7e-05 23.7 0.4 0.00043 19.8 0.2 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO11858.1 - 0.00012 22.2 0.9 0.0008 19.6 0.2 2.8 2 0 0 2 2 2 1 Kelch motif PD40 PF07676.12 ETO11858.1 - 0.00013 21.8 1.4 2.1 8.4 0.0 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Kelch_3 PF13415.6 ETO11858.1 - 0.0007 19.8 0.0 0.0016 18.7 0.0 1.7 1 0 0 1 1 1 1 Galactose oxidase, central domain Nbas_N PF15492.6 ETO11858.1 - 0.0036 16.7 0.3 7.9 5.7 0.0 3.5 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Kelch_5 PF13854.6 ETO11858.1 - 0.0097 15.9 3.3 0.047 13.7 2.1 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO11858.1 - 0.12 12.4 0.9 1.1 9.4 0.1 3.2 3 0 0 3 3 3 0 Kelch motif Fez1 PF06818.15 ETO11859.1 - 0.0027 18.2 14.5 0.0046 17.4 14.5 1.4 1 0 0 1 1 1 1 Fez1 Ax_dynein_light PF10211.9 ETO11859.1 - 6 6.8 14.2 11 5.9 14.2 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain DUF3439 PF11921.8 ETO11860.1 - 0.0061 16.5 10.9 0.0061 16.5 10.9 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO11860.1 - 0.36 10.8 34.9 0.31 11.0 13.6 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein Cullin_binding PF03556.15 ETO11861.1 - 0.051 14.0 0.4 0.061 13.8 0.4 1.1 1 0 0 1 1 1 0 Cullin binding Nro1 PF12753.7 ETO11861.1 - 0.062 12.3 0.4 0.064 12.2 0.4 1.0 1 0 0 1 1 1 0 Nuclear pore complex subunit Nro1 Gal_mutarotas_2 PF13802.6 ETO11861.1 - 0.069 13.5 0.2 0.069 13.5 0.2 2.0 1 1 1 2 2 2 0 Galactose mutarotase-like WD40 PF00400.32 ETO11862.1 - 2.4e-24 85.1 17.3 7.9e-07 29.7 0.8 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11862.1 - 4.5e-09 35.5 1.5 0.019 13.6 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11862.1 - 1.8e-08 34.6 0.2 0.0096 16.2 0.1 3.2 2 2 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO11862.1 - 1.4e-06 27.9 1.3 0.1 11.9 0.1 3.2 1 1 2 3 3 3 3 WD40-like domain DUF4221 PF13970.6 ETO11862.1 - 0.028 14.0 0.3 0.12 11.9 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) DCX PF03607.17 ETO11862.1 - 0.16 12.1 0.1 2.8 8.1 0.0 2.7 3 0 0 3 3 3 0 Doublecortin SLD3 PF08639.10 ETO11865.1 - 0.0015 17.4 8.5 0.0017 17.2 8.5 1.0 1 0 0 1 1 1 1 DNA replication regulator SLD3 Eapp_C PF10238.9 ETO11865.1 - 0.071 13.2 2.7 0.071 13.2 2.7 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein OATP PF03137.20 ETO11865.1 - 0.14 10.4 1.4 0.13 10.6 1.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family XRN_N PF03159.18 ETO11865.1 - 0.17 11.3 4.7 0.2 11.0 4.7 1.2 1 0 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus Presenilin PF01080.17 ETO11865.1 - 0.22 10.3 1.1 0.22 10.3 1.1 1.2 1 0 0 1 1 1 0 Presenilin SpoIIP PF07454.11 ETO11865.1 - 0.23 10.9 5.9 0.27 10.7 5.9 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Vfa1 PF08432.10 ETO11865.1 - 0.32 11.3 17.0 0.47 10.8 15.5 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 ETO11865.1 - 0.35 10.8 14.7 0.44 10.5 14.7 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CDC45 PF02724.14 ETO11865.1 - 0.35 9.1 6.0 0.31 9.3 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4770 PF15994.5 ETO11865.1 - 0.57 10.4 7.9 0.74 10.0 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Connexin PF00029.19 ETO11865.1 - 0.62 9.8 9.2 0.83 9.4 9.2 1.2 1 0 0 1 1 1 0 Connexin EMC3_TMCO1 PF01956.16 ETO11865.1 - 3.2 7.5 5.5 3.2 7.4 5.5 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like MRVI1 PF05781.12 ETO11865.1 - 3.6 6.2 12.5 4.9 5.7 12.5 1.1 1 0 0 1 1 1 0 MRVI1 protein MDM10 PF12519.8 ETO11865.1 - 3.8 6.3 5.7 3.7 6.3 5.7 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 LMBR1 PF04791.16 ETO11865.1 - 4.2 6.2 5.8 4.6 6.0 5.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF2956 PF11169.8 ETO11865.1 - 4.8 7.4 19.1 8.9 6.6 19.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) UvrA_DNA-bind PF17755.1 ETO11866.1 - 0.2 12.0 3.3 0.14 12.5 0.5 2.2 2 0 0 2 2 2 0 UvrA DNA-binding domain DUF2433 PF10360.9 ETO11866.1 - 3.7 7.7 9.0 1.1 9.4 0.5 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2433) PIP5K PF01504.18 ETO11867.1 - 4.4e-55 186.8 2.6 5.6e-55 186.5 2.6 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Synaptobrevin PF00957.21 ETO11867.1 - 0.46 10.3 6.9 2.4 8.0 1.0 2.5 2 0 0 2 2 2 0 Synaptobrevin NACHT PF05729.12 ETO11869.1 - 1.2e-10 41.6 0.0 2.5e-10 40.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO11869.1 - 0.00019 21.7 0.8 0.0011 19.3 0.3 2.5 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO11869.1 - 0.0013 19.3 0.4 0.0072 16.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain T2SSG PF08334.11 ETO11869.1 - 0.0027 17.8 0.3 1.7 8.7 0.0 3.2 3 0 0 3 3 3 1 Type II secretion system (T2SS), protein G RelA_SpoT PF04607.17 ETO11869.1 - 0.0052 17.1 0.3 0.0052 17.1 0.3 2.7 3 0 0 3 3 2 1 Region found in RelA / SpoT proteins AAA_16 PF13191.6 ETO11869.1 - 0.011 16.2 0.1 0.086 13.2 0.0 2.4 1 1 1 2 2 2 0 AAA ATPase domain ATP_bind_2 PF03668.15 ETO11869.1 - 0.019 14.3 0.1 0.059 12.7 0.0 1.8 2 0 0 2 2 2 0 P-loop ATPase protein family RsgA_GTPase PF03193.16 ETO11869.1 - 0.043 13.7 0.5 0.46 10.4 0.1 2.9 2 1 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 ETO11869.1 - 0.046 14.2 0.5 0.24 11.9 0.0 2.4 2 0 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 ETO11869.1 - 0.095 13.1 0.9 0.29 11.5 0.1 2.4 2 1 0 2 2 1 0 RNA helicase Ribosomal_S20p PF01649.18 ETO11869.1 - 0.12 13.1 2.3 0.29 11.8 1.0 2.4 2 0 0 2 2 1 0 Ribosomal protein S20 BORCS7 PF16088.5 ETO11869.1 - 0.27 11.5 7.9 0.05 13.9 1.3 3.2 4 0 0 4 4 4 0 BLOC-1-related complex sub-unit 7 ATPase PF06745.13 ETO11869.1 - 0.44 9.9 8.1 0.68 9.2 0.0 3.8 4 0 0 4 4 4 0 KaiC CDH1_2_SANT_HL1 PF18375.1 ETO11869.1 - 8.1 7.2 7.3 1.1 9.9 1.6 2.6 3 0 0 3 3 1 0 CDH1/2 SANT-Helical linker 1 Flu_M2 PF00599.17 ETO11870.1 - 1.1 9.4 2.8 7.7 6.7 0.1 3.0 3 1 0 3 3 3 0 Influenza Matrix protein (M2) Zip PF02535.22 ETO11871.1 - 0.13 11.5 0.3 0.14 11.3 0.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter L27_1 PF09058.10 ETO11872.1 - 0.059 13.4 0.3 0.21 11.6 0.3 2.0 1 0 0 1 1 1 0 L27_1 RcsC PF09456.10 ETO11872.1 - 0.089 12.8 1.4 1.2 9.1 0.1 2.5 2 1 0 2 2 2 0 RcsC Alpha-Beta-Loop (ABL) Srg PF02118.21 ETO11874.1 - 0.39 10.3 4.9 0.55 9.8 4.9 1.2 1 0 0 1 1 1 0 Srg family chemoreceptor DUF4110 PF13422.6 ETO11875.1 - 0.0098 16.0 1.0 0.016 15.3 1.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4110) FAM176 PF14851.6 ETO11876.1 - 1.3 8.7 3.7 2.4 7.8 3.7 1.4 1 0 0 1 1 1 0 FAM176 family AAA_23 PF13476.6 ETO11876.1 - 1.8 9.0 11.3 5.3 7.5 11.3 1.7 1 1 0 1 1 1 0 AAA domain PRORP PF16953.5 ETO11877.1 - 3.5e-11 43.1 1.9 1.1e-07 31.7 0.7 2.6 2 1 1 3 3 3 2 Protein-only RNase P RNase_Zc3h12a PF11977.8 ETO11877.1 - 0.008 16.0 1.6 0.28 11.0 0.1 2.6 2 1 0 2 2 2 2 Zc3h12a-like Ribonuclease NYN domain tRNA-synt_1_2 PF13603.6 ETO11877.1 - 0.047 13.2 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 Leucyl-tRNA synthetase, Domain 2 WD40 PF00400.32 ETO11878.1 - 5.1e-22 77.8 14.7 0.00039 21.2 0.1 6.0 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11878.1 - 2.3e-06 27.8 0.3 0.66 10.3 0.0 4.0 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain zf-C2HE PF16278.5 ETO11878.1 - 0.051 14.0 0.9 0.25 11.8 0.9 2.2 1 0 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger HEAT PF02985.22 ETO11880.1 - 5.2e-30 100.9 0.1 0.00013 21.9 0.0 9.9 10 0 0 10 10 9 6 HEAT repeat HEAT_2 PF13646.6 ETO11880.1 - 8.2e-25 87.0 0.0 4.6e-08 33.4 0.0 8.2 3 1 7 10 10 9 5 HEAT repeats HEAT_EZ PF13513.6 ETO11880.1 - 8.2e-15 54.9 0.0 0.00016 22.1 0.0 7.2 7 2 1 8 8 5 3 HEAT-like repeat Cnd1 PF12717.7 ETO11880.1 - 1.6e-12 47.8 37.2 5.5e-06 26.5 0.5 7.2 2 1 6 8 8 8 4 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETO11880.1 - 1.4e-11 44.5 16.9 0.24 11.6 0.2 8.3 3 2 3 7 7 7 4 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO11880.1 - 2.1e-09 37.8 24.4 0.0099 16.5 0.1 8.2 5 3 5 10 10 9 4 Vacuolar 14 Fab1-binding region Arm-DNA-bind_2 PF12167.8 ETO11880.1 - 6.2e-06 26.0 1.3 2.2 8.3 0.0 6.7 7 0 0 7 7 7 1 Arm DNA-binding domain CLASP_N PF12348.8 ETO11880.1 - 1.8e-05 24.5 13.4 0.11 12.1 0.2 6.1 3 1 2 7 7 7 2 CLASP N terminal HEAT_PBS PF03130.16 ETO11880.1 - 4.2e-05 23.8 0.1 3.1 8.7 0.0 6.9 10 0 0 10 10 4 1 PBS lyase HEAT-like repeat TIP120 PF08623.10 ETO11880.1 - 0.00011 22.1 23.0 0.28 11.0 0.1 8.1 4 2 8 12 12 12 2 TATA-binding protein interacting (TIP20) IFRD PF05004.13 ETO11880.1 - 0.00017 20.8 16.0 0.38 9.8 1.3 5.8 3 2 1 5 5 5 2 Interferon-related developmental regulator (IFRD) NLE PF08154.12 ETO11880.1 - 0.0016 18.9 19.2 8.5 7.0 0.4 7.5 5 2 3 8 8 7 0 NLE (NUC135) domain TAN PF11640.8 ETO11880.1 - 0.0055 16.8 23.3 0.97 9.6 0.3 7.7 3 2 4 7 7 7 3 Telomere-length maintenance and DNA damage repair DNA_pol3_gamma3 PF12169.8 ETO11880.1 - 0.01 15.8 0.1 45 3.9 0.0 4.5 4 0 0 4 4 4 0 DNA polymerase III subunits gamma and tau domain III DrsE PF02635.15 ETO11880.1 - 0.015 15.7 3.8 0.52 10.7 0.1 3.9 4 0 0 4 4 3 0 DsrE/DsrF-like family Spore_III_AB PF09548.10 ETO11880.1 - 0.015 15.4 21.5 0.48 10.5 1.0 5.8 2 2 4 7 7 7 0 Stage III sporulation protein AB (spore_III_AB) DUF2555 PF10742.9 ETO11880.1 - 0.02 14.7 0.3 62 3.5 0.0 5.2 5 0 0 5 5 5 0 Protein of unknown function (DUF2555) Dopey_N PF04118.14 ETO11880.1 - 0.048 12.8 26.0 0.11 11.6 0.6 5.3 2 2 1 3 3 3 0 Dopey, N-terminal Cache_3-Cache_2 PF17201.4 ETO11880.1 - 0.074 12.3 6.3 1.3 8.2 0.1 3.6 4 0 0 4 4 4 0 Cache 3/Cache 2 fusion domain SPG48 PF14764.6 ETO11880.1 - 0.1 13.1 5.9 0.51 10.8 0.1 3.7 2 1 0 3 3 3 0 AP-5 complex subunit, vesicle trafficking Gcn1_N PF12074.8 ETO11880.1 - 0.12 11.7 3.5 7.3 5.8 0.1 3.1 3 0 0 3 3 3 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal Mog1 PF04603.12 ETO11880.1 - 0.14 12.5 5.1 0.092 13.1 0.4 3.1 4 0 0 4 4 3 0 Ran-interacting Mog1 protein Imm70 PF15601.6 ETO11880.1 - 0.35 10.4 6.1 6.9 6.2 0.1 5.0 5 1 0 5 5 5 0 Immunity protein 70 LapD_MoxY_N PF16448.5 ETO11880.1 - 0.41 10.5 1.2 48 3.8 0.0 3.9 4 1 1 5 5 5 0 LapD/MoxY periplasmic domain Yippee-Mis18 PF03226.14 ETO11880.1 - 0.67 10.2 8.0 14 5.9 0.0 4.3 5 1 0 5 5 4 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF3349 PF11829.8 ETO11880.1 - 1.2 10.0 10.9 1e+02 3.8 0.1 6.6 4 2 4 9 9 7 0 Protein of unknown function (DUF3349) XkdW PF09636.10 ETO11880.1 - 2.6 8.2 13.9 22 5.2 0.1 5.8 3 2 4 7 7 5 0 XkdW protein RecX PF02631.16 ETO11880.1 - 2.7 8.5 5.0 22 5.5 0.0 3.9 4 1 1 5 5 3 0 RecX family IPK PF03770.16 ETO11880.1 - 5.6 6.8 15.7 0.1 12.5 4.1 3.5 2 2 1 4 4 4 0 Inositol polyphosphate kinase DUF4428 PF14471.6 ETO11880.1 - 7.5 6.6 15.4 3.8 7.5 0.1 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF4428) Transposase_1 PF01359.18 ETO11880.1 - 7.7 6.4 6.1 15 5.5 0.0 4.1 5 0 0 5 5 4 0 Transposase (partial DDE domain) ENTH PF01417.20 ETO11880.1 - 8.2 6.5 17.5 6.7 6.8 0.1 6.5 5 3 1 7 7 7 0 ENTH domain Kelch_6 PF13964.6 ETO11881.1 - 5.1e-08 32.9 2.1 2.7 8.4 0.0 5.2 4 1 1 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETO11881.1 - 9.3e-08 32.0 0.1 0.068 13.2 0.0 4.4 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO11881.1 - 0.00014 21.7 1.2 2.8 8.0 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO11881.1 - 0.00048 19.6 8.0 1.6 8.4 0.0 5.1 5 1 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO11881.1 - 0.0047 17.2 0.6 2.4 8.6 0.0 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain TRAPP PF04051.16 ETO11881.1 - 0.0072 16.1 0.0 0.013 15.2 0.0 1.5 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Kelch_2 PF07646.15 ETO11881.1 - 0.016 15.2 4.2 0.98 9.5 0.0 4.4 5 0 0 5 5 5 0 Kelch motif Type_III_YscX PF09474.10 ETO11882.1 - 0.05 13.9 1.6 0.53 10.6 0.2 2.9 3 0 0 3 3 3 0 Type III secretion system YscX (type_III_YscX) RsgA_N PF16745.5 ETO11883.1 - 0.12 12.1 0.3 3.3 7.5 0.0 2.5 2 0 0 2 2 2 0 RsgA N-terminal domain Brix PF04427.18 ETO11884.1 - 2.9e-32 112.3 0.6 3.4e-32 112.1 0.6 1.1 1 0 0 1 1 1 1 Brix domain Kelch_4 PF13418.6 ETO11885.1 - 1.7e-05 24.7 2.6 0.046 13.7 0.2 5.2 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO11885.1 - 8.5e-05 22.5 4.8 0.066 13.2 0.4 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO11885.1 - 0.0017 17.9 3.6 1.7 8.3 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO11885.1 - 0.026 14.8 6.3 8.5 6.8 0.3 5.4 5 0 0 5 5 5 0 Galactose oxidase, central domain 7tm_3 PF00003.22 ETO11886.1 - 2e-35 122.7 25.5 2.8e-35 122.2 25.5 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR FixH PF05751.11 ETO11886.1 - 0.22 11.5 2.5 0.62 10.1 2.5 1.8 1 0 0 1 1 1 0 FixH Chlam_PMP PF02415.17 ETO11886.1 - 1.6 9.4 15.2 16 6.3 0.6 5.3 5 0 0 5 5 5 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat C2 PF00168.30 ETO11887.1 - 7.2e-38 129.0 3.6 2.7e-19 69.4 0.6 2.7 2 0 0 2 2 2 2 C2 domain SMP_LBD PF17047.5 ETO11887.1 - 2.3e-13 50.0 0.1 4.3e-13 49.1 0.1 1.5 1 0 0 1 1 1 1 Synaptotagmin-like mitochondrial-lipid-binding domain CEP76-C2 PF15627.6 ETO11887.1 - 0.0038 16.8 0.1 0.049 13.2 0.0 2.3 2 0 0 2 2 2 1 CEP76 C2 domain 2OG-FeII_Oxy_4 PF13661.6 ETO11887.1 - 1.1 10.0 3.9 4.6 8.0 0.0 3.1 4 0 0 4 4 4 0 2OG-Fe(II) oxygenase superfamily B56 PF01603.20 ETO11888.1 - 6.8e-39 134.0 6.3 2.7e-23 82.6 0.8 2.1 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) B56 PF01603.20 ETO11889.1 - 2.1e-22 79.7 1.3 3.4e-22 79.0 1.3 1.3 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) CAP_GLY PF01302.25 ETO11889.1 - 6e-09 35.8 0.8 1e-08 35.0 0.1 1.8 2 0 0 2 2 2 1 CAP-Gly domain WD40 PF00400.32 ETO11890.1 - 8.5e-16 58.1 9.6 1.1e-07 32.3 0.6 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO11890.1 - 4.8e-05 22.8 0.9 6.4e-05 22.4 0.9 1.2 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO11890.1 - 0.00023 20.0 1.3 0.005 15.6 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11890.1 - 0.00082 19.6 0.1 0.0026 18.0 0.0 1.7 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain ADK_lid PF05191.14 ETO11891.1 - 0.09 12.8 0.3 0.21 11.6 0.3 1.6 1 0 0 1 1 1 0 Adenylate kinase, active site lid Ribonuc_L-PSP PF01042.21 ETO11892.1 - 8.2e-23 80.7 0.1 1.1e-22 80.3 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP AAA_6 PF12774.7 ETO11893.1 - 0.12 11.3 2.1 0.14 11.0 2.1 1.0 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region PHO4 PF01384.20 ETO11894.1 - 0.57 9.2 1.1 0.76 8.8 1.1 1.2 1 0 0 1 1 1 0 Phosphate transporter family HSP70 PF00012.20 ETO11896.1 - 4.9e-56 190.1 0.0 7.9e-19 67.3 0.0 4.0 4 0 0 4 4 4 4 Hsp70 protein MreB_Mbl PF06723.13 ETO11896.1 - 0.00047 19.1 0.0 0.5 9.1 0.0 3.6 3 2 1 4 4 4 2 MreB/Mbl protein Peptidase_S28 PF05577.12 ETO11898.1 - 0.0026 16.6 0.1 0.022 13.6 0.1 2.0 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 ETO11898.1 - 0.012 14.3 0.0 0.015 14.0 0.0 1.0 1 0 0 1 1 1 0 PS-10 peptidase S37 TPR_2 PF07719.17 ETO11899.1 - 1.2e-18 65.7 0.4 5.3e-07 29.3 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11899.1 - 4.2e-15 54.8 1.0 4.2e-08 32.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO11899.1 - 6.2e-09 36.0 0.1 0.23 11.8 0.0 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11899.1 - 3.2e-08 33.1 0.8 0.00012 22.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO11899.1 - 3.7e-07 30.1 2.3 0.0016 18.4 0.1 3.2 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 ETO11899.1 - 1.7e-06 27.6 2.0 0.6 9.9 0.1 3.7 2 1 2 4 4 4 3 TPR repeat FKBP_C PF00254.28 ETO11899.1 - 1.9e-05 24.9 0.1 0.00011 22.5 0.0 2.2 2 1 1 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase TPR_6 PF13174.6 ETO11899.1 - 3.1e-05 24.3 0.1 0.03 14.9 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11899.1 - 4.7e-05 23.1 0.1 0.052 13.6 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11899.1 - 0.00027 21.1 2.5 8.2 7.1 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11899.1 - 0.00028 20.6 0.8 0.081 12.8 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO11899.1 - 0.00035 21.0 0.6 0.082 13.4 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF3271 PF11675.8 ETO11899.1 - 0.00038 19.8 1.1 0.00063 19.1 0.9 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3271) TPR_16 PF13432.6 ETO11899.1 - 0.00071 20.2 0.0 1.7 9.3 0.0 3.0 3 1 0 3 3 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11899.1 - 0.00074 20.1 0.0 0.27 12.2 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO11899.1 - 0.0015 18.7 0.4 0.046 13.9 0.4 2.5 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_21 PF09976.9 ETO11899.1 - 0.017 14.9 1.0 0.051 13.3 0.1 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat-like domain TPR_9 PF13371.6 ETO11899.1 - 0.025 14.7 0.0 0.24 11.6 0.0 2.3 3 0 0 3 3 2 0 Tetratricopeptide repeat Rad51 PF08423.11 ETO11899.1 - 0.094 12.0 0.8 0.12 11.6 0.8 1.1 1 0 0 1 1 1 0 Rad51 TPR_20 PF14561.6 ETO11899.1 - 0.11 12.9 2.0 15 6.0 0.1 2.8 1 1 2 3 3 3 0 Tetratricopeptide repeat ETRAMP PF09716.10 ETO11899.1 - 0.16 12.1 0.1 0.16 12.1 0.1 2.2 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FXR_C3 PF16097.5 ETO11899.1 - 0.68 10.7 6.1 0.2 12.4 2.9 1.8 2 0 0 2 2 1 0 Fragile X-related 1 protein C-terminal region 3 FKBP_C PF00254.28 ETO11900.1 - 1.1e-22 80.2 0.0 5.7e-13 49.0 0.0 3.1 3 0 0 3 3 3 2 FKBP-type peptidyl-prolyl cis-trans isomerase Baculo_11_kDa PF06143.11 ETO11900.1 - 0.12 11.9 1.3 0.82 9.3 0.3 2.2 2 0 0 2 2 2 0 Baculovirus 11 kDa family Holin_BhlA PF10960.8 ETO11900.1 - 0.17 11.9 0.2 0.17 11.9 0.2 2.5 3 0 0 3 3 3 0 BhlA holin family ATP-synt_8 PF00895.20 ETO11900.1 - 0.53 10.8 3.2 0.6 10.6 1.4 2.1 2 0 0 2 2 2 0 ATP synthase protein 8 Lac_bphage_repr PF06543.12 ETO11900.1 - 1.1 9.3 4.5 15 5.7 0.1 2.6 2 0 0 2 2 2 0 Lactococcus bacteriophage repressor DUF5436 PF17504.2 ETO11900.1 - 2.8 8.3 6.8 1.3 9.4 1.4 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5436) TTC5_OB PF16669.5 ETO11901.1 - 2.4e-12 46.6 0.1 4.3e-12 45.7 0.1 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat protein 5 OB fold domain DUF2101 PF09874.9 ETO11901.1 - 0.023 14.4 1.2 0.037 13.7 1.2 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Mucin PF01456.17 ETO11901.1 - 1 9.3 17.9 0.028 14.4 11.5 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3439 PF11921.8 ETO11901.1 - 1.7 8.6 9.4 0.49 10.4 5.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) HNF-1_N PF04814.13 ETO11901.1 - 1.8 9.2 8.8 0.25 11.9 4.5 1.7 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus SSP160 PF06933.11 ETO11901.1 - 3 5.9 23.7 1 7.5 20.2 1.7 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Macoilin PF09726.9 ETO11901.1 - 3.1 6.2 10.5 4 5.9 10.5 1.1 1 0 0 1 1 1 0 Macoilin family MFS_5 PF05631.14 ETO11902.1 - 7e-66 222.5 23.0 3.7e-57 193.8 13.4 3.5 3 1 0 3 3 3 2 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 ETO11902.1 - 1.1e-06 27.8 32.5 0.00026 20.0 24.8 4.2 1 1 2 3 3 3 2 Major Facilitator Superfamily DUF2631 PF10939.8 ETO11902.1 - 0.041 13.7 1.0 19 5.2 0.0 3.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2631) KilA-N PF04383.13 ETO11902.1 - 0.12 12.3 0.1 0.3 10.9 0.1 1.7 1 0 0 1 1 1 0 KilA-N domain TMEM213 PF15192.6 ETO11902.1 - 0.18 11.8 1.1 0.49 10.4 1.1 1.7 1 0 0 1 1 1 0 TMEM213 family Cytochrom_B561 PF03188.16 ETO11903.1 - 1.7e-10 41.2 4.7 1.7e-10 41.2 4.7 2.2 3 0 0 3 3 3 1 Eukaryotic cytochrome b561 TauE PF01925.19 ETO11903.1 - 0.005 16.5 9.1 0.0081 15.8 9.1 1.2 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE DOMON PF03351.17 ETO11903.1 - 0.015 15.5 3.3 0.078 13.2 0.1 2.8 2 1 0 2 2 2 0 DOMON domain PT PF04886.12 ETO11904.1 - 3.8e-06 26.3 43.6 0.065 12.8 24.9 3.3 1 1 1 2 2 2 2 PT repeat Pneumo_att_G PF05539.11 ETO11904.1 - 1.5 8.3 7.0 3.3 7.2 7.0 1.5 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G DOMON PF03351.17 ETO11905.1 - 0.0034 17.6 0.0 0.01 16.0 0.0 1.8 1 0 0 1 1 1 1 DOMON domain NUDIX PF00293.28 ETO11906.1 - 1.8e-11 44.2 0.0 4.5e-11 42.9 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain zf-Di19 PF05605.12 ETO11906.1 - 0.0085 16.4 0.9 0.0085 16.4 0.9 2.4 2 0 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding TLP-20 PF06088.11 ETO11906.1 - 1.2 9.0 3.8 0.78 9.6 0.1 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) AFG1_ATPase PF03969.16 ETO11907.1 - 4.3e-76 256.2 7.1 2.8e-70 237.0 5.0 3.9 2 1 0 2 2 2 2 AFG1-like ATPase UvrD-helicase PF00580.21 ETO11907.1 - 0.0014 18.2 2.6 0.6 9.6 1.1 3.1 2 1 0 2 2 2 2 UvrD/REP helicase N-terminal domain TniB PF05621.11 ETO11907.1 - 0.011 15.1 0.1 0.035 13.5 0.1 1.9 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 ETO11907.1 - 0.018 15.3 0.0 0.06 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO11907.1 - 0.043 14.3 0.0 0.043 14.3 0.0 2.3 3 0 0 3 3 3 0 AAA domain Sigma54_activ_2 PF14532.6 ETO11907.1 - 0.051 13.7 0.0 0.64 10.1 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 ETO11907.1 - 0.052 13.9 1.1 7.4 6.9 1.5 3.0 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 ETO11907.1 - 0.09 12.9 0.0 8.3 6.4 0.0 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain BAR_3 PF16746.5 ETO11907.1 - 1.5 8.5 10.1 0.1 12.3 2.0 2.6 3 0 0 3 3 3 0 BAR domain of APPL family ATPase_2 PF01637.18 ETO11907.1 - 1.7 8.5 5.0 12 5.7 0.8 3.0 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea WD40 PF00400.32 ETO11908.1 - 6.2e-19 68.0 14.3 0.0075 17.1 0.2 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11908.1 - 7.6e-07 29.4 0.1 5.5 7.4 0.0 5.3 3 3 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain MyTH4 PF00784.17 ETO11910.1 - 0.046 14.2 1.0 0.1 13.1 0.2 2.1 2 0 0 2 2 2 0 MyTH4 domain SAM_1 PF00536.30 ETO11911.1 - 2.3e-09 37.6 0.9 6.3e-09 36.2 0.9 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO11911.1 - 2.7e-06 27.4 0.3 6.5e-06 26.2 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Clr2 PF10383.9 ETO11911.1 - 6.1 7.6 7.2 0.66 10.7 0.2 2.9 3 0 0 3 3 3 0 Transcription-silencing protein Clr2 ZZ PF00569.17 ETO11912.1 - 7.8e-15 54.4 4.7 1.3e-14 53.7 4.7 1.4 1 0 0 1 1 1 1 Zinc finger, ZZ type zf-UBR PF02207.20 ETO11912.1 - 0.85 9.8 9.2 2.1 8.6 9.2 1.6 1 1 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Secretin_N_2 PF07655.13 ETO11912.1 - 3 8.4 18.8 0.45 11.1 7.8 2.8 2 0 0 2 2 2 0 Secretin N-terminal domain N_BRCA1_IG PF16158.5 ETO11913.1 - 1.4e-13 51.4 0.0 3.9e-13 50.0 0.0 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene CARDB PF07705.11 ETO11913.1 - 0.027 14.7 0.0 0.027 14.7 0.0 1.8 2 0 0 2 2 2 0 CARDB UBA PF00627.31 ETO11913.1 - 0.042 13.8 0.0 0.17 11.8 0.0 2.0 1 0 0 1 1 1 0 UBA/TS-N domain ZZ PF00569.17 ETO11913.1 - 1 9.2 5.8 3.5 7.5 5.8 1.8 1 1 0 1 1 1 0 Zinc finger, ZZ type CTP_transf_like PF01467.26 ETO11914.1 - 1.1e-10 41.9 0.0 3.6e-10 40.2 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like RIO1 PF01163.22 ETO11915.1 - 0.039 13.6 0.0 0.11 12.1 0.0 1.7 1 1 1 2 2 2 0 RIO1 family WD40 PF00400.32 ETO11916.1 - 4.4e-18 65.3 4.1 3.1e-07 31.0 0.4 3.8 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO11916.1 - 1.3e-06 27.4 1.6 0.0078 14.9 0.1 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO11916.1 - 0.0034 17.6 0.0 2 8.8 0.0 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain MetW PF07021.12 ETO11916.1 - 0.063 12.9 0.1 0.092 12.3 0.1 1.3 1 0 0 1 1 1 0 Methionine biosynthesis protein MetW DUF1541 PF07563.11 ETO11916.1 - 0.11 12.4 0.0 11 6.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) EnY2 PF10163.9 ETO11918.1 - 1.8e-29 101.9 0.8 2.3e-29 101.6 0.8 1.1 1 0 0 1 1 1 1 Transcription factor e(y)2 ERp29 PF07749.12 ETO11918.1 - 0.076 13.9 0.4 0.16 12.9 0.2 1.7 1 1 1 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain Rox3 PF08633.10 ETO11919.1 - 0.02 15.2 0.5 0.02 15.2 0.5 1.8 1 1 1 2 2 2 0 Rox3 mediator complex subunit Syntaxin-18_N PF10496.9 ETO11919.1 - 0.03 14.6 2.3 0.053 13.8 1.9 1.7 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus bZIP_1 PF00170.21 ETO11919.1 - 0.036 14.2 11.9 0.076 13.1 6.8 2.7 1 1 1 2 2 2 0 bZIP transcription factor Mer2 PF09074.10 ETO11919.1 - 0.081 12.7 10.1 0.019 14.8 5.4 1.9 1 1 1 2 2 2 0 Mer2 DUF3402 PF11882.8 ETO11919.1 - 0.084 12.0 10.6 0.095 11.8 10.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) Oberon_cc PF16312.5 ETO11919.1 - 0.24 11.4 15.2 0.35 10.8 15.2 1.3 1 0 0 1 1 1 0 Coiled-coil region of Oberon DUF1635 PF07795.11 ETO11919.1 - 0.45 10.3 8.4 0.54 10.1 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) FAM167 PF11652.8 ETO11919.1 - 0.61 10.6 5.3 12 6.4 0.1 2.5 1 1 1 2 2 2 0 FAM167 Seryl_tRNA_N PF02403.22 ETO11919.1 - 0.8 10.0 14.2 2 8.7 7.3 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain zf-C4H2 PF10146.9 ETO11919.1 - 0.8 10.0 11.3 0.93 9.8 11.3 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein ACCA PF03255.14 ETO11919.1 - 0.93 9.4 11.9 0.18 11.7 5.7 2.2 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF836 PF05768.14 ETO11919.1 - 1 9.8 5.4 5.3 7.5 5.4 2.0 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) DUF507 PF04368.13 ETO11919.1 - 1.1 9.2 14.0 0.62 10.0 10.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF507) IFT20 PF14931.6 ETO11919.1 - 1.8 8.8 18.1 2.4 8.3 7.7 2.6 1 1 1 2 2 2 0 Intraflagellar transport complex B, subunit 20 CorA PF01544.18 ETO11919.1 - 1.8 7.8 7.3 2.4 7.4 7.3 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Fib_alpha PF08702.10 ETO11919.1 - 1.9 8.7 12.3 4.4 7.5 10.1 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3106 PF11304.8 ETO11919.1 - 3 8.4 15.1 0.23 11.9 10.4 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3106) SID-1_RNA_chan PF13965.6 ETO11919.1 - 3.1 6.1 4.2 4.1 5.7 4.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DALR_1 PF05746.15 ETO11919.1 - 3.2 8.0 8.7 7.9 6.7 8.2 1.9 1 1 1 2 2 2 0 DALR anticodon binding domain SlyX PF04102.12 ETO11919.1 - 5.8 7.6 17.9 0.76 10.4 1.0 3.2 1 1 1 2 2 2 0 SlyX Cytochrom_C_2 PF01322.20 ETO11919.1 - 6.4 7.7 10.4 0.78 10.6 4.0 2.2 1 1 1 2 2 2 0 Cytochrome C' ABC_membrane PF00664.23 ETO11920.1 - 1.2e-11 44.8 15.4 5.9e-07 29.4 6.9 2.4 2 1 0 2 2 2 2 ABC transporter transmembrane region ABC_tran PF00005.27 ETO11920.1 - 2.1e-06 28.3 2.2 2.3e-06 28.2 0.5 1.9 2 0 0 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETO11920.1 - 0.0051 16.5 0.1 0.011 15.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain ATP_bind_1 PF03029.17 ETO11920.1 - 0.014 15.2 0.3 1 9.1 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein MeaB PF03308.16 ETO11920.1 - 0.014 14.4 0.0 0.027 13.5 0.0 1.4 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB Dynamin_N PF00350.23 ETO11920.1 - 0.043 13.9 3.1 0.044 13.8 1.3 1.9 2 0 0 2 2 2 0 Dynamin family GTP_EFTU PF00009.27 ETO11920.1 - 0.068 12.7 0.4 0.39 10.2 0.1 2.1 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO11920.1 - 0.079 13.0 0.2 0.23 11.5 0.2 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ETO11920.1 - 0.096 12.5 0.9 0.17 11.6 0.9 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ETO11920.1 - 0.11 12.4 2.3 0.27 11.1 0.1 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 ETO11920.1 - 0.19 11.3 1.2 0.35 10.4 0.4 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DUF4006 PF13179.6 ETO11920.1 - 2 8.4 5.2 21 5.1 0.1 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF4006) TRAF_BIRC3_bd PF16673.5 ETO11921.1 - 5.5 6.9 10.2 6.7 6.6 1.4 3.8 3 0 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain ApoO PF09769.9 ETO11921.1 - 9.2 6.2 6.9 16 5.4 0.1 3.6 3 2 1 4 4 4 0 Apolipoprotein O TPR_12 PF13424.6 ETO11922.1 - 1.8e-56 188.4 2.7 9.4e-14 51.5 0.5 6.4 4 2 3 7 7 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO11922.1 - 9.6e-39 129.7 30.1 4e-06 26.4 1.5 8.5 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO11922.1 - 2.8e-33 112.9 0.4 1.3e-05 24.8 0.0 8.4 8 1 1 9 9 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11922.1 - 3.4e-29 98.6 22.8 0.0018 18.2 0.0 8.7 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11922.1 - 1.9e-27 93.1 32.5 4.7e-05 23.3 0.3 8.8 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO11922.1 - 2.9e-22 77.0 3.7 0.01 15.8 0.2 8.4 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11922.1 - 1.3e-10 41.2 0.0 0.39 11.7 0.0 7.7 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11922.1 - 2.3e-09 37.3 9.1 4.4 8.1 0.0 8.5 9 1 1 10 10 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO11922.1 - 5.5e-06 26.0 20.9 3.9 7.2 0.1 8.4 7 1 2 9 9 9 1 TPR repeat DUF5113 PF17140.4 ETO11922.1 - 7e-06 25.9 28.6 0.049 13.4 0.2 7.2 3 2 5 8 8 8 2 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETO11922.1 - 2e-05 24.6 17.0 2.6 8.6 0.1 7.7 8 1 0 8 8 7 2 Tetratricopeptide repeat SPO22 PF08631.10 ETO11922.1 - 0.0011 18.5 5.8 0.1 12.1 0.6 3.5 2 2 1 3 3 3 1 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 ETO11922.1 - 0.0019 18.1 9.6 0.27 11.3 0.2 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO11922.1 - 0.0074 16.9 0.0 9.3 7.0 0.0 4.9 7 0 0 7 7 6 0 Tetratricopeptide repeat RPN7 PF10602.9 ETO11922.1 - 0.0076 16.0 16.1 0.25 11.0 0.7 5.1 1 1 2 4 4 4 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETO11922.1 - 0.0095 16.4 2.9 2.4 8.7 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat Prefoldin PF02996.17 ETO11922.1 - 0.022 14.7 2.9 0.16 11.9 0.1 3.8 2 1 2 4 4 4 0 Prefoldin subunit HTH_Bact PF18768.1 ETO11922.1 - 0.033 13.8 5.8 0.71 9.5 0.2 4.3 4 1 1 5 5 5 0 Helix-turn-helix bacterial domain SHNi-TPR PF10516.9 ETO11922.1 - 0.033 13.6 7.8 21 4.7 0.1 6.0 7 0 0 7 7 7 0 SHNi-TPR Foie-gras_1 PF11817.8 ETO11922.1 - 0.057 13.0 1.7 0.72 9.4 0.2 2.4 1 1 1 2 2 2 0 Foie gras liver health family 1 MIT PF04212.18 ETO11922.1 - 0.11 12.6 9.6 19 5.4 0.2 5.9 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO11922.1 - 0.32 11.3 3.6 9.8 6.7 0.0 4.9 6 0 0 6 6 6 0 PPR repeat WD40 PF00400.32 ETO11923.1 - 2.7e-28 97.6 12.5 1.5e-06 28.8 0.2 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11923.1 - 1.4e-13 50.9 0.7 0.11 12.7 0.0 5.2 4 1 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11923.1 - 2.6e-06 26.4 1.2 0.1 11.2 0.1 3.8 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO11923.1 - 0.0031 16.5 0.4 0.33 9.9 0.1 2.8 1 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein SprB PF13573.6 ETO11923.1 - 0.0063 16.3 4.3 0.42 10.4 0.6 3.6 3 0 0 3 3 3 1 SprB repeat eIF2A PF08662.11 ETO11923.1 - 0.042 13.7 0.9 5.3 6.9 0.0 2.9 3 0 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Ycf70 PF17382.2 ETO11924.1 - 0.0043 17.4 0.9 0.0043 17.4 0.9 1.6 1 1 0 1 1 1 1 Uncharacterized Ycf70-like ATG16 PF08614.11 ETO11925.1 - 0.00023 21.5 12.4 0.0026 18.0 12.4 2.0 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) APG6_N PF17675.1 ETO11925.1 - 0.024 15.2 8.4 0.024 15.2 8.4 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region NPV_P10 PF05531.12 ETO11925.1 - 0.1 13.0 1.3 11 6.5 1.2 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 ETO11925.1 - 0.16 12.1 13.8 0.092 12.9 8.6 2.2 2 0 0 2 2 2 0 Tropomyosin like SKA2 PF16740.5 ETO11925.1 - 0.21 11.4 12.1 2.1 8.2 0.5 2.8 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 FlxA PF14282.6 ETO11925.1 - 0.23 11.5 11.4 0.61 10.1 6.8 2.5 2 1 0 2 2 2 0 FlxA-like protein Med9 PF07544.13 ETO11925.1 - 0.26 11.4 7.0 0.88 9.7 4.1 2.6 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 ZapB PF06005.12 ETO11925.1 - 0.45 11.0 11.7 0.63 10.5 6.5 2.7 2 0 0 2 2 2 0 Cell division protein ZapB I_LWEQ PF01608.17 ETO11925.1 - 0.61 10.3 8.4 0.45 10.8 3.4 2.8 1 1 2 3 3 3 0 I/LWEQ domain Corazonin PF17308.2 ETO11925.1 - 0.62 10.4 9.3 0.07 13.5 4.4 1.9 2 0 0 2 2 2 0 Pro-corazonin Cnn_1N PF07989.11 ETO11925.1 - 0.98 9.6 17.3 0.36 11.0 12.3 2.8 2 1 2 4 4 4 0 Centrosomin N-terminal motif 1 Rx_N PF18052.1 ETO11925.1 - 1.4 9.2 9.6 22 5.4 0.1 3.1 2 1 1 3 3 3 0 Rx N-terminal domain DUF724 PF05266.14 ETO11925.1 - 1.7 8.4 10.7 0.67 9.8 6.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Spc7 PF08317.11 ETO11925.1 - 2.1 7.2 13.4 0.26 10.1 7.8 1.9 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF3450 PF11932.8 ETO11925.1 - 4.2 6.6 12.3 1.6 7.9 6.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) LigB PF02900.18 ETO11926.1 - 3.5e-10 39.4 0.0 4.2e-10 39.1 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase CSD PF00313.22 ETO11927.1 - 7.3e-08 32.2 3.3 3e-05 23.8 0.3 3.0 4 0 0 4 4 3 2 'Cold-shock' DNA-binding domain RNA_pol_Rbc25 PF08292.12 ETO11927.1 - 0.057 13.6 1.7 0.057 13.6 1.7 2.4 3 0 0 3 3 3 0 RNA polymerase III subunit Rpc25 DUF4175 PF13779.6 ETO11927.1 - 0.14 10.0 9.9 0.19 9.6 9.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TMEM232 PF15877.5 ETO11927.1 - 0.33 9.9 3.0 0.51 9.3 0.0 2.0 2 0 0 2 2 2 0 Transmembrane protein family 232 PAT1 PF09770.9 ETO11927.1 - 0.76 8.0 18.4 0.84 7.8 18.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Roughex PF06020.11 ETO11927.1 - 0.78 8.8 5.6 1.3 8.1 5.6 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Androgen_recep PF02166.16 ETO11927.1 - 1.5 7.6 18.2 2.3 7.0 18.2 1.3 1 0 0 1 1 1 0 Androgen receptor DUF4820 PF16091.5 ETO11927.1 - 1.7 8.0 7.5 0.46 9.8 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Hid1 PF12722.7 ETO11927.1 - 3.4 5.7 9.1 3.5 5.6 9.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SelP_N PF04592.14 ETO11927.1 - 6.5 6.1 29.8 13 5.1 29.8 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FAM176 PF14851.6 ETO11927.1 - 9.3 5.9 7.7 3.2 7.4 1.6 2.4 2 0 0 2 2 2 0 FAM176 family Calpain_III PF01067.22 ETO11929.1 - 0.044 14.0 0.5 0.058 13.7 0.5 1.1 1 0 0 1 1 1 0 Calpain large subunit, domain III DUF4770 PF15994.5 ETO11929.1 - 0.13 12.5 2.8 0.16 12.2 2.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) V_ATPase_I PF01496.19 ETO11930.1 - 0.00063 17.8 0.1 0.00078 17.5 0.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ETO11930.1 - 0.014 13.7 9.5 0.016 13.5 9.5 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO11930.1 - 0.017 14.6 14.3 0.022 14.2 14.3 1.2 1 0 0 1 1 1 0 SDA1 SAPS PF04499.15 ETO11930.1 - 0.19 10.5 8.5 0.22 10.2 8.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BUD22 PF09073.10 ETO11930.1 - 0.49 9.7 19.9 0.64 9.3 19.9 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO11930.1 - 0.88 7.7 20.4 1.1 7.4 20.4 1.0 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 ETO11930.1 - 1.2 8.2 10.9 1.9 7.6 10.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter U79_P34 PF03064.16 ETO11930.1 - 2 7.7 18.2 3.8 6.8 18.2 1.5 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Presenilin PF01080.17 ETO11930.1 - 7.6 5.2 8.6 11 4.7 8.6 1.2 1 0 0 1 1 1 0 Presenilin RNA_helicase PF00910.22 ETO11933.1 - 0.00027 21.3 0.3 0.035 14.5 0.0 3.0 3 0 0 3 3 3 1 RNA helicase RsgA_GTPase PF03193.16 ETO11933.1 - 0.00034 20.5 0.2 0.015 15.2 0.0 2.3 1 1 1 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 ETO11933.1 - 0.0012 18.4 0.1 0.0025 17.4 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETO11933.1 - 0.0012 19.3 0.0 0.0045 17.5 0.0 2.0 2 0 0 2 2 2 1 ABC transporter NACHT PF05729.12 ETO11933.1 - 0.0037 17.2 0.0 0.0076 16.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO11933.1 - 0.0054 17.0 0.1 0.039 14.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain PUB PF09409.10 ETO11933.1 - 0.011 15.7 0.0 0.027 14.4 0.0 1.7 1 0 0 1 1 1 0 PUB domain MMR_HSR1 PF01926.23 ETO11933.1 - 0.013 15.6 0.0 4.2 7.5 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase Rad17 PF03215.15 ETO11933.1 - 0.016 15.2 3.3 0.67 9.8 0.0 2.4 1 1 1 2 2 2 0 Rad17 P-loop domain ATPase_2 PF01637.18 ETO11933.1 - 0.016 15.1 1.1 0.036 14.0 0.0 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Viral_helicase1 PF01443.18 ETO11933.1 - 0.019 14.7 0.2 0.11 12.2 0.0 2.2 2 1 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_5 PF07728.14 ETO11933.1 - 0.022 14.7 0.0 0.067 13.2 0.0 1.8 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) Roc PF08477.13 ETO11933.1 - 0.027 14.7 0.1 1.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 ETO11933.1 - 0.032 14.7 2.0 0.034 14.6 0.1 1.9 1 1 1 2 2 2 0 AAA domain AAA_21 PF13304.6 ETO11933.1 - 0.048 13.5 0.0 0.077 12.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA PF00004.29 ETO11933.1 - 0.054 13.9 0.0 0.17 12.3 0.0 1.9 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO11933.1 - 0.06 13.7 0.0 0.14 12.5 0.0 1.8 2 0 0 2 2 1 0 AAA ATPase domain TsaE PF02367.17 ETO11933.1 - 0.085 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE MCM PF00493.23 ETO11933.1 - 0.09 11.9 0.0 1.3 8.0 0.0 2.5 2 1 1 3 3 3 0 MCM P-loop domain CENP-L PF13092.6 ETO11934.1 - 0.023 14.9 0.1 0.049 13.9 0.1 1.5 1 0 0 1 1 1 0 Kinetochore complex Sim4 subunit Fta1 RRN3 PF05327.11 ETO11934.1 - 1.3 7.5 14.4 2.3 6.6 14.4 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO11934.1 - 6.2 4.8 20.4 8.9 4.3 20.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi zf-RanBP PF00641.18 ETO11936.1 - 0.00048 19.4 32.4 0.0013 18.0 6.8 3.5 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others Zf_RING PF16744.5 ETO11936.1 - 2 8.6 16.6 9.9 6.4 0.2 4.0 4 0 0 4 4 4 0 KIAA1045 RING finger Chromo_2 PF18704.1 ETO11937.1 - 5.8e-05 23.3 0.4 0.00015 21.9 0.3 1.8 2 0 0 2 2 2 1 Chromatin organization modifier domain 2 Mistic PF11458.8 ETO11937.1 - 0.095 12.7 0.2 6.5 6.8 0.0 2.7 3 0 0 3 3 3 0 Membrane-integrating protein Mistic RabGAP-TBC PF00566.18 ETO11938.1 - 0.11 12.2 0.0 0.11 12.2 0.0 2.0 2 0 0 2 2 2 0 Rab-GTPase-TBC domain Guanylate_kin PF00625.21 ETO11939.1 - 1e-40 139.4 1.4 2.9e-38 131.4 1.4 2.2 1 1 0 1 1 1 1 Guanylate kinase AAA_18 PF13238.6 ETO11939.1 - 4.9e-08 33.6 0.1 4.9e-08 33.6 0.1 1.6 2 0 0 2 2 1 1 AAA domain AAA_22 PF13401.6 ETO11939.1 - 3.1e-05 24.3 0.1 6e-05 23.3 0.1 1.8 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO11939.1 - 3.4e-05 23.8 0.1 8.5e-05 22.5 0.0 1.7 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO11939.1 - 5e-05 23.4 0.1 8.7e-05 22.6 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Rad17 PF03215.15 ETO11939.1 - 0.00044 20.2 0.0 0.00085 19.3 0.0 1.5 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 ETO11939.1 - 0.00052 20.5 1.2 0.0092 16.5 1.2 2.2 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ETO11939.1 - 0.0044 17.4 0.0 0.0057 17.1 0.0 1.5 1 1 0 1 1 1 1 AAA ATPase domain AAA_33 PF13671.6 ETO11939.1 - 0.0048 17.1 2.2 0.016 15.4 1.1 2.3 2 1 0 2 2 1 1 AAA domain Roc PF08477.13 ETO11939.1 - 0.019 15.1 0.0 0.037 14.2 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO11939.1 - 0.021 14.5 0.0 0.035 13.7 0.0 1.4 1 0 0 1 1 1 0 Ras family RNA_helicase PF00910.22 ETO11939.1 - 0.027 14.8 0.0 0.16 12.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA_17 PF13207.6 ETO11939.1 - 0.036 14.5 0.6 0.22 11.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain dNK PF01712.19 ETO11939.1 - 0.041 13.7 0.6 8.5 6.2 0.0 2.4 1 1 1 2 2 2 0 Deoxynucleoside kinase AAA_28 PF13521.6 ETO11939.1 - 0.067 13.4 0.0 0.17 12.1 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_14 PF13173.6 ETO11939.1 - 0.08 13.0 0.2 0.18 11.8 0.2 1.9 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ETO11939.1 - 0.081 12.1 0.1 0.17 11.0 0.1 1.6 1 1 0 1 1 1 0 NB-ARC domain MCM PF00493.23 ETO11939.1 - 0.083 12.0 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain AAA_30 PF13604.6 ETO11939.1 - 0.12 12.1 0.0 0.16 11.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain Thymidylate_kin PF02223.17 ETO11939.1 - 0.21 11.2 4.5 0.38 10.4 0.0 2.6 2 1 1 3 3 3 0 Thymidylate kinase WBP-1 PF11669.8 ETO11940.1 - 0.65 10.6 4.8 12 6.6 0.9 2.5 2 1 0 2 2 2 0 WW domain-binding protein 1 DUF4059 PF13268.6 ETO11940.1 - 2.3 8.7 14.1 8.4 6.9 1.5 3.9 3 1 1 4 4 4 0 Protein of unknown function (DUF4059) GREB1 PF15782.5 ETO11941.1 - 0.78 6.8 14.9 0.92 6.5 14.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer FYDLN_acid PF09538.10 ETO11941.1 - 7.6 7.3 11.7 3.8 8.2 2.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RhoGAP PF00620.27 ETO11942.1 - 3e-24 85.6 0.5 1.8e-13 50.6 0.0 3.0 2 1 0 3 3 3 2 RhoGAP domain ORC5_C PF14630.6 ETO11943.1 - 1.1 8.7 5.8 1.2 8.6 5.1 1.6 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus RGS PF00615.19 ETO11945.1 - 2.5e-08 34.2 0.0 4.4e-08 33.4 0.0 1.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 ETO11946.1 - 1.3e-26 92.3 17.0 2e-05 25.3 0.8 6.8 6 2 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11946.1 - 6.1e-09 36.1 1.8 0.017 15.4 0.0 4.2 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO11946.1 - 2e-06 26.8 1.0 0.53 8.9 0.0 4.1 1 1 3 4 4 4 4 Nucleoporin Nup120/160 MMR_HSR1_Xtn PF16897.5 ETO11947.1 - 1.1e-38 131.5 1.2 2.7e-38 130.2 1.1 1.8 2 0 0 2 2 2 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ETO11947.1 - 1.7e-22 79.2 0.0 3.6e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ETO11947.1 - 1e-17 64.2 0.0 3.3e-17 62.6 0.0 1.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO11947.1 - 1.4e-08 34.4 0.0 3.6e-08 33.1 0.0 1.7 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ETO11947.1 - 0.023 14.7 0.3 5 7.2 0.2 2.6 1 1 0 2 2 2 0 Dynamin family Roc PF08477.13 ETO11947.1 - 0.095 12.9 0.0 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Claudin_3 PF06653.11 ETO11948.1 - 0.0056 16.6 0.8 0.0056 16.6 0.8 2.2 2 0 0 2 2 2 1 Tight junction protein, Claudin-like DUF4131 PF13567.6 ETO11948.1 - 0.11 12.1 2.2 0.6 9.7 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MNHE PF01899.16 ETO11948.1 - 0.98 9.2 6.2 0.72 9.6 0.7 2.2 2 0 0 2 2 2 0 Na+/H+ ion antiporter subunit Ac76 PF05814.11 ETO11948.1 - 1.9 8.5 10.7 3.2 7.8 2.0 2.9 2 1 0 2 2 2 0 Orf76 (Ac76) DUF2663 PF10864.8 ETO11948.1 - 2.2 8.7 6.3 0.92 9.9 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) RasGAP PF00616.19 ETO11949.1 - 9e-23 81.1 3.5 9e-23 81.1 3.5 3.4 3 1 1 4 4 4 1 GTPase-activator protein for Ras-like GTPase GCR1_C PF12550.8 ETO11949.1 - 0.0035 17.6 1.1 0.71 10.2 0.0 3.0 3 0 0 3 3 3 1 Transcriptional activator of glycolytic enzymes SDA1 PF05285.12 ETO11949.1 - 0.068 12.6 25.4 0.091 12.2 7.9 2.1 2 0 0 2 2 2 0 SDA1 DUF4770 PF15994.5 ETO11949.1 - 0.11 12.7 9.6 0.19 12.0 3.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SpoIIIAH PF12685.7 ETO11949.1 - 0.34 10.7 18.2 1.7 8.4 6.8 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF2457 PF10446.9 ETO11949.1 - 0.47 9.6 25.6 0.39 9.8 3.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) CLN3 PF02487.17 ETO11949.1 - 4.1 6.4 9.9 4.7 6.1 1.6 2.2 2 0 0 2 2 2 0 CLN3 protein AKAP7_NLS PF10469.9 ETO11950.1 - 4.9e-20 72.3 8.5 4.2e-18 66.0 8.5 2.7 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ETO11950.1 - 0.00019 21.3 0.0 0.00037 20.4 0.0 1.4 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily LigT_PEase PF02834.16 ETO11950.1 - 0.0046 17.1 0.0 4.3 7.6 0.0 2.4 2 0 0 2 2 2 2 LigT like Phosphoesterase Guanylate_kin PF00625.21 ETO11951.1 - 1.7e-20 73.5 2.5 4.3e-12 46.1 0.8 3.4 1 1 1 2 2 2 2 Guanylate kinase AAA_22 PF13401.6 ETO11951.1 - 0.0001 22.6 0.6 0.0013 19.1 0.3 2.2 1 1 1 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETO11951.1 - 0.00013 21.9 0.0 0.00028 20.9 0.0 1.7 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 ETO11951.1 - 0.00016 22.2 1.2 0.001 19.6 1.2 2.0 1 1 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ETO11951.1 - 0.00031 20.8 0.0 0.00055 20.0 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ETO11951.1 - 0.0013 19.1 0.2 0.0028 18.1 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain NTPase_1 PF03266.15 ETO11951.1 - 0.0084 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 NTPase AAA_7 PF12775.7 ETO11951.1 - 0.0095 15.5 0.0 0.048 13.2 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETO11951.1 - 0.012 16.2 1.1 0.094 13.2 1.1 2.2 1 1 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ETO11951.1 - 0.014 15.8 0.0 0.028 14.8 0.0 1.5 1 0 0 1 1 1 0 RNA helicase ATPase_2 PF01637.18 ETO11951.1 - 0.021 14.7 0.0 0.042 13.8 0.0 1.5 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ETO11951.1 - 0.026 14.7 3.5 0.031 14.4 0.6 2.6 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ETO11951.1 - 0.035 14.5 0.1 0.11 13.0 0.1 2.0 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ETO11951.1 - 0.058 13.3 0.0 0.095 12.6 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain cobW PF02492.19 ETO11951.1 - 0.084 12.5 0.0 0.18 11.3 0.0 1.6 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Tubulin_C PF03953.17 ETO11954.1 - 1.8e-07 31.4 0.0 2.5e-07 30.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain FAM177 PF14774.6 ETO11955.1 - 3.7e-10 40.2 10.1 1.1e-09 38.7 9.8 2.0 1 1 0 1 1 1 1 FAM177 family EIAV_GP90 PF00971.18 ETO11955.1 - 0.11 11.2 0.9 0.14 10.8 0.9 1.1 1 0 0 1 1 1 0 EIAV coat protein, gp90 DUF2433 PF10360.9 ETO11955.1 - 0.15 12.2 5.5 0.12 12.5 2.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2433) Prefoldin_2 PF01920.20 ETO11956.1 - 0.003 17.5 5.9 0.54 10.2 0.0 3.5 2 1 1 3 3 3 1 Prefoldin subunit TMF_TATA_bd PF12325.8 ETO11956.1 - 0.0054 16.9 8.0 0.0054 16.9 8.0 2.9 3 0 0 3 3 3 1 TATA element modulatory factor 1 TATA binding UvrD-helicase PF00580.21 ETO11956.1 - 0.014 14.9 0.1 0.021 14.4 0.1 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain RNA_binding PF01877.17 ETO11956.1 - 0.017 15.4 1.0 0.053 13.8 0.5 2.1 1 1 1 2 2 2 0 RNA binding FapA PF03961.13 ETO11956.1 - 0.028 13.1 0.6 0.037 12.6 0.1 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A Corona_S2 PF01601.16 ETO11956.1 - 0.031 12.8 2.8 2.2 6.7 0.2 2.1 2 0 0 2 2 2 0 Coronavirus S2 glycoprotein Syntaxin-6_N PF09177.11 ETO11956.1 - 0.044 14.3 1.5 0.044 14.3 1.5 2.5 3 0 0 3 3 3 0 Syntaxin 6, N-terminal HEPN_Apea PF18739.1 ETO11956.1 - 0.14 12.6 3.6 0.25 11.8 0.3 2.5 1 1 1 2 2 2 0 Apea-like HEPN DUF2937 PF11157.8 ETO11956.1 - 0.26 11.0 1.9 15 5.3 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) DUF3450 PF11932.8 ETO11956.1 - 0.29 10.4 8.6 0.032 13.5 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Fzo_mitofusin PF04799.13 ETO11956.1 - 0.29 10.7 5.3 3.9 7.0 0.2 2.3 2 0 0 2 2 2 0 fzo-like conserved region BLOC1_2 PF10046.9 ETO11956.1 - 0.73 10.2 7.5 0.54 10.6 4.9 2.2 3 1 0 3 3 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Wtap PF17098.5 ETO11956.1 - 0.88 9.5 9.1 5.8 6.8 9.1 2.5 1 1 0 1 1 1 0 WTAP/Mum2p family DUF4600 PF15372.6 ETO11956.1 - 1.8 9.0 12.1 1.6 9.2 4.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) FliJ PF02050.16 ETO11956.1 - 2.4 8.4 17.8 0.43 10.8 3.6 2.8 3 0 0 3 3 3 0 Flagellar FliJ protein Spc7 PF08317.11 ETO11956.1 - 2.8 6.7 14.5 0.61 8.9 6.9 2.3 2 0 0 2 2 2 0 Spc7 kinetochore protein HTH_3 PF01381.22 ETO11957.1 - 7e-11 42.0 0.0 9.8e-11 41.6 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ETO11957.1 - 1.5e-08 34.9 0.0 1.9e-08 34.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_19 PF12844.7 ETO11957.1 - 2.9e-05 24.0 0.0 4.3e-05 23.5 0.0 1.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_25 PF13413.6 ETO11957.1 - 0.00023 20.9 0.0 0.00037 20.3 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_37 PF13744.6 ETO11957.1 - 0.0033 17.4 0.0 0.0061 16.5 0.0 1.4 1 0 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 ETO11957.1 - 0.099 12.8 0.0 0.13 12.4 0.0 1.2 1 0 0 1 1 1 0 Antitoxin component of bacterial toxin-antitoxin system, MqsA D123 PF07065.14 ETO11958.1 - 1.3e-17 63.9 5.4 1.3e-17 63.9 5.4 3.2 3 2 0 3 3 3 1 D123 SET PF00856.28 ETO11958.1 - 2.2e-13 51.0 4.9 4.5e-12 46.7 0.0 2.9 3 0 0 3 3 3 2 SET domain R2K_2 PF18299.1 ETO11958.1 - 0.0071 16.2 0.1 0.027 14.3 0.0 2.1 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ETO11958.1 - 0.075 13.0 0.0 0.18 11.8 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 DUF1993 PF09351.10 ETO11958.1 - 0.42 10.8 4.5 0.13 12.4 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1993) DUF2407_C PF13373.6 ETO11958.1 - 0.72 10.0 5.5 0.29 11.3 0.8 2.4 2 0 0 2 2 2 0 DUF2407 C-terminal domain Nucleoside_tran PF01733.18 ETO11959.1 - 1.4e-12 47.7 7.1 1.4e-12 47.7 7.1 2.6 2 1 0 3 3 3 1 Nucleoside transporter Plasmodium_Vir PF05795.11 ETO11959.1 - 0.2 11.1 1.7 0.31 10.4 1.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Abhydrolase_9_N PF15420.6 ETO11959.1 - 9.9 6.1 11.7 15 5.5 10.0 2.0 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus Nucleoside_tran PF01733.18 ETO11960.1 - 4.3e-18 65.7 18.2 9.5e-17 61.3 9.3 2.2 1 1 1 2 2 2 2 Nucleoside transporter Cys_Met_Meta_PP PF01053.20 ETO11961.1 - 3.7e-32 111.3 0.3 1.3e-21 76.5 0.0 2.5 1 1 1 2 2 2 2 Cys/Met metabolism PLP-dependent enzyme EF-hand_8 PF13833.6 ETO11962.1 - 3.5e-13 49.2 0.0 2.9e-08 33.4 0.0 3.1 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_7 PF13499.6 ETO11962.1 - 3.3e-12 46.7 0.0 6e-10 39.4 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO11962.1 - 3.6e-12 44.9 0.0 2.6e-06 26.6 0.0 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO11962.1 - 9.7e-10 37.6 0.0 6.1e-06 25.8 0.0 3.1 3 0 0 3 3 3 2 EF-hand domain EF-hand_9 PF14658.6 ETO11962.1 - 6.5e-07 29.6 0.0 5.7e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain GPHH PF16905.5 ETO11962.1 - 0.021 14.6 0.0 16 5.4 0.0 3.0 3 0 0 3 3 3 0 Voltage-dependent L-type calcium channel, IQ-associated DUF2608 PF11019.8 ETO11962.1 - 0.029 13.9 0.1 0.03 13.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) DUF2179 PF10035.9 ETO11962.1 - 0.93 9.3 3.2 39 4.1 0.0 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2179) Skp1 PF01466.19 ETO11964.1 - 2.9e-26 91.3 0.2 2.9e-26 91.3 0.2 2.0 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Myb_DNA-binding PF00249.31 ETO11964.1 - 0.059 13.6 0.1 1.8 8.8 0.0 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain Peptidase_C65 PF10275.9 ETO11965.1 - 0.0067 15.9 0.3 0.011 15.2 0.2 1.5 1 1 0 1 1 1 1 Peptidase C65 Otubain Myotub-related PF06602.14 ETO11966.1 - 7.8e-06 25.0 1.6 1.9e-05 23.8 0.1 1.9 1 1 1 2 2 2 1 Myotubularin-like phosphatase domain RRM_Rrp7 PF17799.1 ETO11966.1 - 0.075 12.8 0.5 0.11 12.3 0.0 1.5 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Ras PF00071.22 ETO11967.1 - 5.3e-43 146.4 0.4 6.4e-43 146.2 0.4 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO11967.1 - 1.3e-21 77.0 0.0 2e-21 76.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO11967.1 - 9.5e-09 34.9 0.0 1.1e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO11967.1 - 7.9e-05 22.1 0.1 9.3e-05 21.9 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ATP_bind_1 PF03029.17 ETO11967.1 - 0.029 14.2 0.0 0.04 13.7 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein V_ATPase_I PF01496.19 ETO11968.1 - 3.7e-188 627.2 12.2 4.4e-188 626.9 12.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family LRR19-TM PF15176.6 ETO11968.1 - 0.00062 19.7 0.2 0.0018 18.2 0.2 1.8 1 0 0 1 1 1 1 Leucine-rich repeat family 19 TM domain Tmemb_9 PF05434.11 ETO11968.1 - 0.21 11.5 6.9 0.085 12.7 1.7 2.6 2 1 0 2 2 2 0 TMEM9 TRAP_alpha PF03896.16 ETO11968.1 - 0.29 10.3 3.0 0.19 10.9 0.6 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Pkinase PF00069.25 ETO11969.1 - 1.4e-09 37.7 0.1 0.00034 20.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO11969.1 - 0.0081 15.5 0.2 0.31 10.3 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Meleagrin PF08189.11 ETO11970.1 - 0.11 12.2 0.1 0.25 11.1 0.1 1.5 1 0 0 1 1 1 0 Meleagrin/Cygnin family WD40 PF00400.32 ETO11973.1 - 0.0022 18.8 1.2 0.73 10.8 0.1 3.8 3 0 0 3 3 3 2 WD domain, G-beta repeat MIEAP PF16026.5 ETO11975.1 - 0.018 15.3 0.0 0.052 13.8 0.0 1.8 1 0 0 1 1 1 0 Mitochondria-eating protein zf-C3HC PF07967.13 ETO11977.1 - 7.7e-05 22.7 1.0 9.9e-05 22.4 0.7 1.4 1 1 0 1 1 1 1 C3HC zinc finger-like TPP_enzyme_N PF02776.18 ETO11978.1 - 3e-38 131.1 0.0 4.3e-38 130.6 0.0 1.1 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain POR_N PF01855.19 ETO11978.1 - 0.0055 16.5 0.0 0.0075 16.0 0.0 1.1 1 0 0 1 1 1 1 Pyruvate flavodoxin/ferredoxin oxidoreductase, thiamine diP-bdg DoxX PF07681.12 ETO11981.1 - 4.6e-06 27.1 8.9 8e-06 26.4 8.9 1.4 1 0 0 1 1 1 1 DoxX Sigma_reg_N PF13800.6 ETO11981.1 - 0.017 15.4 0.0 0.017 15.4 0.0 2.4 2 1 1 3 3 3 0 Sigma factor regulator N-terminal DDE_Tnp_IS66_C PF13817.6 ETO11981.1 - 0.023 14.9 0.1 0.048 13.9 0.1 1.5 1 0 0 1 1 1 0 IS66 C-terminal element ABC_membrane_3 PF13748.6 ETO11981.1 - 0.063 12.5 3.0 0.053 12.7 1.8 1.5 2 0 0 2 2 2 0 ABC transporter transmembrane region Tetraspanin PF00335.20 ETO11981.1 - 0.11 12.2 2.7 0.16 11.6 2.7 1.3 1 0 0 1 1 1 0 Tetraspanin family DUF202 PF02656.15 ETO11981.1 - 0.23 12.0 2.3 0.23 11.9 0.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF202) HR_lesion PF05514.11 ETO11981.1 - 0.25 11.5 5.1 0.44 10.7 0.5 2.5 2 1 0 2 2 2 0 HR-like lesion-inducing FSA_C PF10479.9 ETO11982.1 - 1.7 6.6 12.8 2.4 6.2 12.8 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus WD40 PF00400.32 ETO11983.1 - 0.0045 17.8 0.4 4.4 8.3 0.0 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat RINGv PF12906.7 ETO11983.1 - 0.19 11.9 2.0 0.52 10.5 2.0 1.7 1 0 0 1 1 1 0 RING-variant domain Thioredoxin PF00085.20 ETO11984.1 - 5.3e-25 87.4 0.1 1.4e-18 66.8 0.0 3.2 3 0 0 3 3 3 2 Thioredoxin ERp29 PF07749.12 ETO11984.1 - 8.5e-13 49.0 0.0 3.5e-12 47.1 0.0 2.1 1 1 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Thioredoxin_6 PF13848.6 ETO11984.1 - 2.1e-06 27.8 0.2 0.0081 16.1 0.0 2.7 2 1 0 2 2 2 2 Thioredoxin-like domain OST3_OST6 PF04756.13 ETO11984.1 - 3.7e-06 26.5 0.0 0.0002 20.8 0.0 2.2 1 1 1 2 2 2 1 OST3 / OST6 family, transporter family HyaE PF07449.11 ETO11984.1 - 0.031 14.2 0.0 0.13 12.2 0.0 2.0 2 0 0 2 2 2 0 Hydrogenase-1 expression protein HyaE ERp29_N PF07912.13 ETO11984.1 - 0.063 13.4 0.1 0.57 10.3 0.0 2.3 2 0 0 2 2 2 0 ERp29, N-terminal domain Methyltr_RsmB-F PF01189.17 ETO11985.1 - 8.5e-22 77.8 0.1 1.1e-17 64.3 0.1 2.3 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F HD PF01966.22 ETO11986.1 - 7.8e-07 29.3 0.9 1.4e-06 28.5 0.9 1.4 1 0 0 1 1 1 1 HD domain DUF1247 PF06851.11 ETO11986.1 - 0.0062 16.5 1.0 0.014 15.3 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1247) DUF4473 PF14747.6 ETO11986.1 - 0.018 15.6 0.1 0.059 13.9 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4473) WD40 PF00400.32 ETO11990.1 - 8e-54 178.4 22.6 1.2e-11 45.0 0.1 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO11990.1 - 5.5e-20 71.5 3.8 0.0011 19.2 0.0 5.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO11990.1 - 9e-12 44.6 2.5 0.015 14.3 0.0 5.1 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO11990.1 - 5.2e-08 31.8 0.7 0.011 14.3 0.4 3.0 1 1 3 4 4 4 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO11990.1 - 3.8e-06 26.5 0.5 0.035 13.4 0.0 3.8 1 1 3 4 4 4 3 WD40-like domain DUF5570 PF17731.1 ETO11990.1 - 0.0073 16.4 2.1 0.32 11.1 0.1 3.4 2 1 3 5 5 5 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO11990.1 - 0.054 13.5 5.3 20 5.3 0.1 4.3 3 1 1 4 4 4 0 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 ETO11990.1 - 0.076 12.1 0.3 5.2 6.0 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETO11990.1 - 1 9.1 11.9 18 5.2 0.0 5.4 6 1 0 6 6 6 0 Proteasome subunit A N-terminal signature HALZ PF02183.18 ETO11991.1 - 0.00055 20.1 28.9 0.015 15.5 3.9 5.4 4 1 1 5 5 5 2 Homeobox associated leucine zipper AIP3 PF03915.13 ETO11991.1 - 0.0021 17.3 0.6 0.0021 17.3 0.6 2.5 2 1 1 3 3 2 1 Actin interacting protein 3 GCN5L1 PF06320.13 ETO11991.1 - 0.0059 16.7 1.4 0.0059 16.7 1.4 4.1 2 2 2 4 4 2 1 GCN5-like protein 1 (GCN5L1) Laminin_II PF06009.12 ETO11991.1 - 0.0084 16.1 3.5 0.0084 16.1 3.5 3.3 1 1 2 3 3 2 1 Laminin Domain II CALCOCO1 PF07888.11 ETO11991.1 - 0.0092 14.9 37.1 0.014 14.3 37.1 1.3 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like Prefoldin PF02996.17 ETO11991.1 - 0.012 15.5 3.3 0.012 15.5 3.3 5.5 3 2 3 6 6 6 0 Prefoldin subunit JIP_LZII PF16471.5 ETO11991.1 - 0.024 14.8 5.2 0.024 14.8 5.2 4.6 2 2 3 5 5 5 0 JNK-interacting protein leucine zipper II DUF3450 PF11932.8 ETO11991.1 - 0.046 13.0 48.5 0.024 13.9 5.5 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Taxilin PF09728.9 ETO11991.1 - 0.055 12.6 45.6 0.14 11.3 2.7 3.5 1 1 1 3 3 3 0 Myosin-like coiled-coil protein DUF724 PF05266.14 ETO11991.1 - 0.31 10.8 37.1 0.086 12.7 6.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Spc7 PF08317.11 ETO11991.1 - 0.46 9.3 42.6 3.6 6.4 30.2 2.4 1 1 1 2 2 2 0 Spc7 kinetochore protein Cluap1 PF10234.9 ETO11991.1 - 0.84 9.0 40.5 1.5 8.2 28.2 2.1 1 1 1 2 2 2 0 Clusterin-associated protein-1 GAS PF13851.6 ETO11991.1 - 0.85 8.9 48.5 2 7.7 17.9 3.4 2 2 1 3 3 3 0 Growth-arrest specific micro-tubule binding End3 PF12761.7 ETO11991.1 - 0.91 9.7 35.9 0.18 12.0 14.1 3.1 1 1 2 3 3 3 0 Actin cytoskeleton-regulatory complex protein END3 ZapB PF06005.12 ETO11991.1 - 1.9 9.0 49.0 0.19 12.2 8.6 5.1 2 2 2 4 4 4 0 Cell division protein ZapB THOC7 PF05615.13 ETO11991.1 - 2.1 8.6 38.0 0.84 9.9 8.1 3.7 2 2 1 3 3 3 0 Tho complex subunit 7 ATP-synt_D PF01813.17 ETO11991.1 - 4.8 7.0 23.7 3.7 7.3 0.7 3.6 1 1 2 3 3 3 0 ATP synthase subunit D ATG16 PF08614.11 ETO11991.1 - 5.1 7.3 46.7 0.095 12.9 32.7 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 ETO11991.1 - 6.6 7.1 30.4 2.3 8.6 0.3 4.0 2 2 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4201 PF13870.6 ETO11991.1 - 7.4 6.3 43.4 0.34 10.6 18.5 3.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 ETO11991.1 - 8.2 5.7 35.1 2.1 7.6 2.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4686 PF15742.5 ETO11991.1 - 9 5.3 58.9 0.062 12.4 41.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) DUF4062 PF13271.6 ETO11991.1 - 9.2 6.7 7.1 6.9 7.1 2.3 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4062) Ank_2 PF12796.7 ETO11992.1 - 3.9e-29 101.1 1.2 2.5e-13 50.4 0.1 4.3 1 1 3 4 4 4 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO11992.1 - 9.4e-21 73.9 0.1 5.5e-12 46.0 0.1 4.6 3 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO11992.1 - 2.4e-20 70.4 0.1 5.5e-05 23.3 0.0 5.5 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 ETO11992.1 - 3.4e-18 65.2 0.4 5.1e-08 33.0 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ETO11992.1 - 8.8e-18 64.1 3.5 1e-06 28.9 0.1 5.5 4 1 2 6 6 6 4 Ankyrin repeats (many copies) ATG16 PF08614.11 ETO11992.1 - 0.0034 17.6 17.4 0.0034 17.6 17.4 2.5 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) CHASE6_C PF17150.4 ETO11992.1 - 1.1 10.0 5.1 8.1 7.2 5.1 2.4 1 1 0 1 1 1 0 C-terminal domain of two-partite extracellular sensor domain Laminin_II PF06009.12 ETO11992.1 - 4 7.5 19.1 1.7 8.7 12.2 2.8 3 0 0 3 3 3 0 Laminin Domain II TPR_MLP1_2 PF07926.12 ETO11992.1 - 4.4 7.4 33.2 0.21 11.6 22.0 2.7 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF3450 PF11932.8 ETO11992.1 - 4.8 6.4 18.4 1 8.6 13.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) SKA2 PF16740.5 ETO11992.1 - 4.8 7.0 21.5 20 5.0 0.5 3.5 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 FlaC_arch PF05377.11 ETO11992.1 - 6.9 7.1 12.3 5.2 7.5 1.8 3.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Glyco_tranf_2_4 PF13704.6 ETO11994.1 - 8.2e-05 23.1 2.1 0.00057 20.3 2.1 2.2 1 1 0 1 1 1 1 Glycosyl transferase family 2 Secretin_N_2 PF07655.13 ETO11994.1 - 0.00078 19.9 11.8 0.002 18.7 7.4 2.3 2 0 0 2 2 2 1 Secretin N-terminal domain Apc15p PF05841.11 ETO11994.1 - 0.0039 18.0 9.1 0.0039 18.0 9.1 1.8 2 0 0 2 2 2 1 Apc15p protein Glyco_hydro_47 PF01532.20 ETO11996.1 - 4.7e-64 217.0 0.0 1.5e-50 172.5 0.0 2.0 2 0 0 2 2 2 2 Glycosyl hydrolase family 47 DUF4378 PF14309.6 ETO11997.1 - 0.014 15.8 0.0 1.6 9.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4378) Cmc1 PF08583.10 ETO11998.1 - 0.00023 21.1 3.9 0.00044 20.2 3.9 1.5 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CX9C PF16860.5 ETO11998.1 - 0.00085 19.3 2.8 0.0015 18.5 2.8 1.4 1 0 0 1 1 1 1 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, TPR_19 PF14559.6 ETO11999.1 - 1.8e-06 28.3 0.3 0.013 16.0 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO11999.1 - 0.00074 19.5 0.0 0.19 12.0 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO11999.1 - 0.00089 19.2 2.9 0.077 13.1 0.0 3.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO11999.1 - 0.0068 17.1 0.0 11 7.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO11999.1 - 0.021 15.5 0.4 5.6 7.8 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO11999.1 - 0.034 14.5 4.9 0.11 13.0 0.0 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat DUF2811 PF10929.8 ETO11999.1 - 0.039 14.2 1.3 8.4 6.8 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2811) TPR_1 PF00515.28 ETO11999.1 - 0.042 13.7 0.2 1.8 8.5 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO11999.1 - 0.058 13.5 0.0 1.2 9.3 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF816 PF05674.12 ETO12000.1 - 0.0038 17.2 0.4 0.0072 16.3 0.4 1.5 1 0 0 1 1 1 1 Baculovirus protein of unknown function (DUF816) TPR_8 PF13181.6 ETO12000.1 - 0.0086 16.2 0.4 0.49 10.7 0.2 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12000.1 - 0.028 14.5 1.4 0.65 10.2 0.4 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12000.1 - 0.6 10.0 3.6 2.8 7.9 1.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_transf_20 PF00982.21 ETO12001.1 - 7.1e-106 354.7 0.0 7.1e-105 351.4 0.0 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ETO12001.1 - 2.1e-38 131.8 0.0 6.2e-38 130.2 0.0 1.8 2 0 0 2 2 2 1 Trehalose-phosphatase Glycos_transf_1 PF00534.20 ETO12001.1 - 0.024 14.2 0.0 0.065 12.8 0.0 1.7 2 0 0 2 2 2 0 Glycosyl transferases group 1 FAP206 PF12018.8 ETO12002.1 - 0.0042 16.6 1.3 0.0042 16.6 1.3 2.0 2 0 0 2 2 2 1 Domain of unknown function Syntaxin_2 PF14523.6 ETO12002.1 - 0.0059 17.0 9.5 0.0059 17.0 9.5 2.0 2 0 0 2 2 2 1 Syntaxin-like protein Sec34 PF04136.15 ETO12002.1 - 0.021 14.7 1.2 0.021 14.7 1.2 3.0 2 1 1 3 3 3 0 Sec34-like family SOAR PF16533.5 ETO12002.1 - 0.021 14.8 10.0 0.2 11.6 2.2 3.2 2 1 1 3 3 3 0 STIM1 Orai1-activating region GAS PF13851.6 ETO12002.1 - 0.35 10.2 13.3 0.064 12.6 8.5 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding RB_B PF01857.20 ETO12002.1 - 0.51 10.4 4.5 2.4 8.2 4.2 2.1 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain FRB_dom PF08771.11 ETO12002.1 - 0.58 10.6 6.1 9.7 6.7 6.1 2.5 1 1 0 1 1 1 0 FKBP12-rapamycin binding domain Mod_r PF07200.13 ETO12002.1 - 1.1 9.4 14.5 0.16 12.0 8.0 2.4 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein Syntaxin-6_N PF09177.11 ETO12002.1 - 3.1 8.4 8.2 23 5.6 8.2 2.5 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Fib_alpha PF08702.10 ETO12002.1 - 6 7.1 14.1 24 5.1 7.7 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 ETO12002.1 - 8.6 5.5 10.1 0.56 9.4 4.3 1.7 2 0 0 2 2 2 0 TMPIT-like protein Mucin PF01456.17 ETO12003.1 - 8.1 6.4 13.4 0.074 13.0 5.0 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein EF-hand_1 PF00036.32 ETO12004.1 - 6.8e-07 28.4 0.1 0.00029 20.1 0.1 3.2 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO12004.1 - 2.1e-06 27.2 0.7 0.00078 19.2 0.1 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO12004.1 - 3.7e-05 24.1 0.9 0.00012 22.5 0.0 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO12004.1 - 5.4e-05 22.5 1.1 0.00012 21.4 0.2 2.1 2 0 0 2 2 2 1 EF hand GAPT PF11770.8 ETO12005.1 - 0.02 14.8 0.4 0.048 13.5 0.1 1.7 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) WD40 PF00400.32 ETO12006.1 - 1.6e-30 104.7 21.1 7.9e-07 29.7 0.2 7.0 6 3 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12006.1 - 7.4e-07 29.4 3.2 0.16 12.3 0.0 4.2 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12006.1 - 7e-05 21.7 6.6 0.53 8.9 0.1 4.2 2 1 2 4 4 4 3 Nucleoporin Nup120/160 PUB PF09409.10 ETO12007.1 - 0.012 15.6 0.1 0.05 13.5 0.0 2.1 2 0 0 2 2 2 0 PUB domain Ank_4 PF13637.6 ETO12008.1 - 5.7e-13 49.1 0.1 3.1e-06 27.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO12008.1 - 4.1e-08 33.3 0.1 8.2e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO12008.1 - 4.2e-08 33.7 0.1 6.8e-08 33.0 0.1 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO12008.1 - 4.9e-07 29.6 0.2 0.00092 19.5 0.0 2.8 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETO12008.1 - 0.00046 20.5 0.1 0.31 11.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeat RNF111_N PF15303.6 ETO12009.1 - 0.00098 19.0 3.2 0.00098 19.0 3.2 1.5 2 0 0 2 2 2 1 E3 ubiquitin-protein ligase Arkadia N-terminus DUF1882 PF08966.11 ETO12009.1 - 0.12 12.7 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1882) SID-1_RNA_chan PF13965.6 ETO12010.1 - 0.045 12.2 8.9 0.24 9.8 1.8 2.1 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 YMF19 PF02326.15 ETO12010.1 - 0.055 14.2 4.4 0.055 14.2 4.4 4.0 2 1 2 4 4 4 0 Plant ATP synthase F0 C2 PF00168.30 ETO12011.1 - 2.8e-20 72.5 0.1 6.3e-20 71.4 0.1 1.6 1 0 0 1 1 1 1 C2 domain HALZ PF02183.18 ETO12011.1 - 5.1e-05 23.4 63.4 0.001 19.2 5.0 7.4 5 1 2 7 7 6 3 Homeobox associated leucine zipper ADIP PF11559.8 ETO12011.1 - 8e-05 22.8 87.8 0.00017 21.7 15.2 5.9 1 1 5 6 6 6 3 Afadin- and alpha -actinin-Binding Myosin_tail_1 PF01576.19 ETO12011.1 - 0.00011 20.2 78.1 0.00049 18.1 25.0 2.1 1 1 1 2 2 2 2 Myosin tail FPP PF05911.11 ETO12011.1 - 0.00041 18.7 30.7 0.00041 18.7 30.7 3.7 2 1 2 4 4 3 2 Filament-like plant protein, long coiled-coil M PF02370.16 ETO12011.1 - 0.00043 20.5 15.8 0.011 16.2 0.5 12.4 10 4 4 16 16 9 5 M protein repeat APG6_N PF17675.1 ETO12011.1 - 0.00051 20.6 104.3 0.02 15.4 29.2 5.5 1 1 4 5 5 5 3 Apg6 coiled-coil region BLOC1_2 PF10046.9 ETO12011.1 - 0.00059 20.1 69.5 0.048 14.0 9.5 6.9 1 1 4 6 6 6 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Spc7 PF08317.11 ETO12011.1 - 0.00062 18.7 25.8 0.00062 18.7 25.8 4.1 1 1 3 4 4 4 2 Spc7 kinetochore protein GAS PF13851.6 ETO12011.1 - 0.0007 19.0 93.7 0.17 11.2 24.3 5.2 1 1 4 5 5 5 3 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ETO12011.1 - 0.0012 18.9 25.6 0.0012 18.9 25.6 5.2 1 1 5 6 6 6 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 ETO12011.1 - 0.0027 18.1 17.7 0.0027 18.1 17.7 8.0 2 1 5 7 7 6 3 Cell division protein ZapB HOOK PF05622.12 ETO12011.1 - 0.0051 15.0 85.8 0.039 12.1 46.0 2.6 1 1 1 2 2 2 2 HOOK protein DUF3450 PF11932.8 ETO12011.1 - 0.0061 15.9 15.6 0.0061 15.9 15.6 5.3 1 1 2 4 4 4 2 Protein of unknown function (DUF3450) bZIP_2 PF07716.15 ETO12011.1 - 0.0068 16.5 2.0 0.0068 16.5 2.0 9.4 6 2 3 9 9 8 3 Basic region leucine zipper Tektin PF03148.14 ETO12011.1 - 0.0068 15.2 69.4 0.088 11.5 9.4 4.1 2 2 2 4 4 4 4 Tektin family bZIP_1 PF00170.21 ETO12011.1 - 0.008 16.2 1.5 0.008 16.2 1.5 9.0 3 1 7 10 10 9 5 bZIP transcription factor ATG16 PF08614.11 ETO12011.1 - 0.014 15.7 36.4 0.014 15.7 36.4 4.2 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) PspA_IM30 PF04012.12 ETO12011.1 - 0.015 14.9 5.1 0.015 14.9 5.1 5.5 1 1 4 5 5 5 0 PspA/IM30 family KASH_CCD PF14662.6 ETO12011.1 - 0.022 14.6 89.3 0.19 11.6 27.1 4.6 1 1 3 4 4 4 0 Coiled-coil region of CCDC155 or KASH DUF4407 PF14362.6 ETO12011.1 - 0.025 14.0 62.5 0.28 10.5 25.1 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) DDR PF08841.10 ETO12011.1 - 0.028 13.4 0.7 0.057 12.4 0.7 1.4 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain CALCOCO1 PF07888.11 ETO12011.1 - 0.034 13.0 74.3 0.035 13.0 18.3 3.1 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like SHE3 PF17078.5 ETO12011.1 - 0.058 13.1 80.4 0.24 11.1 7.6 3.9 2 1 2 4 4 4 0 SWI5-dependent HO expression protein 3 DUF3287 PF11690.8 ETO12011.1 - 0.098 12.4 20.4 0.16 11.7 0.3 5.4 2 2 2 5 5 5 0 Protein of unknown function (DUF3287) UPF0184 PF03670.13 ETO12011.1 - 0.21 12.0 22.6 0.12 12.8 3.0 4.2 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) Tropomyosin PF00261.20 ETO12011.1 - 0.22 10.8 73.7 0.01 15.2 52.7 2.6 1 1 1 2 2 1 0 Tropomyosin WXG100 PF06013.12 ETO12011.1 - 0.58 10.4 39.1 0.24 11.6 1.6 6.6 3 2 3 6 6 6 0 Proteins of 100 residues with WXG TPR_MLP1_2 PF07926.12 ETO12011.1 - 0.77 9.8 97.8 1.3 9.1 10.3 4.7 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 ETO12011.1 - 1.6 8.9 93.0 0.066 13.4 18.0 5.2 1 1 4 5 5 5 0 JNK_SAPK-associated protein-1 DUF1664 PF07889.12 ETO12011.1 - 2 8.5 45.5 0.21 11.6 2.1 5.8 1 1 7 8 8 8 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 ETO12011.1 - 3.2 8.3 50.9 0.45 11.1 8.8 6.2 1 1 3 4 4 3 0 Syntaxin 6, N-terminal MtrB PF05440.12 ETO12011.1 - 4.2 7.9 4.7 15 6.1 0.1 4.0 4 1 1 5 5 3 0 Tetrahydromethanopterin S-methyltransferase subunit B ERM PF00769.19 ETO12011.1 - 7.4 6.3 92.0 7.8 6.2 48.3 3.4 1 1 2 3 3 3 0 Ezrin/radixin/moesin family DMPK_coil PF08826.10 ETO12011.1 - 8.9 6.5 72.6 0.027 14.6 10.5 7.6 4 2 2 7 7 7 0 DMPK coiled coil domain like DUF4472 PF14739.6 ETO12011.1 - 9.8 7.0 77.1 0.033 14.9 14.5 5.6 1 1 4 5 5 4 0 Domain of unknown function (DUF4472) DUF1149 PF06619.11 ETO12012.1 - 0.93 9.8 4.9 1.6 9.0 4.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1149) Sec62 PF03839.16 ETO12012.1 - 2.1 7.8 13.6 2.6 7.5 13.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 SAM_2 PF07647.17 ETO12014.1 - 0.038 14.1 2.7 4.7 7.4 0.0 3.0 1 1 2 3 3 3 0 SAM domain (Sterile alpha motif) DUF2457 PF10446.9 ETO12014.1 - 0.5 9.4 11.1 0.54 9.3 11.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CBM26 PF16738.5 ETO12015.1 - 0.055 13.7 0.5 0.071 13.4 0.1 1.5 2 0 0 2 2 2 0 Starch-binding module 26 H-kinase_dim PF02895.14 ETO12016.1 - 0.078 13.4 0.9 0.4 11.1 0.3 2.7 2 0 0 2 2 2 0 Signal transducing histidine kinase, homodimeric domain ACP_PD PF04336.12 ETO12016.1 - 0.19 12.1 0.1 0.19 12.1 0.1 3.8 3 2 1 4 4 4 0 Acyl carrier protein phosphodiesterase DUF3391 PF11871.8 ETO12016.1 - 2 8.9 5.8 27 5.3 5.5 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF3391) EST1_DNA_bind PF10373.9 ETO12017.1 - 0.005 16.3 2.7 0.009 15.5 2.7 1.4 1 0 0 1 1 1 1 Est1 DNA/RNA binding domain Flavodoxin_3 PF12641.7 ETO12017.1 - 0.047 13.4 0.2 0.072 12.8 0.2 1.3 1 0 0 1 1 1 0 Flavodoxin domain YojJ PF10372.9 ETO12018.1 - 0.0036 17.4 4.2 0.0065 16.5 4.2 1.4 1 0 0 1 1 1 1 Bacterial membrane-spanning protein N-terminus Rx_N PF18052.1 ETO12018.1 - 0.0053 17.0 3.5 0.0082 16.4 2.7 1.8 1 1 1 2 2 2 1 Rx N-terminal domain DUF4446 PF14584.6 ETO12018.1 - 0.012 15.6 2.5 0.016 15.2 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) IZUMO PF15005.6 ETO12018.1 - 0.026 15.0 6.0 0.032 14.7 6.0 1.1 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated EMP24_GP25L PF01105.24 ETO12018.1 - 0.11 12.4 3.2 0.14 12.1 3.2 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UPF0242 PF06785.11 ETO12018.1 - 9.9 6.2 15.3 16 5.6 15.3 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Csm1_N PF18504.1 ETO12019.1 - 0.003 17.9 8.4 0.0047 17.2 8.4 1.4 1 0 0 1 1 1 1 Csm1 N-terminal domain HAP1_N PF04849.13 ETO12019.1 - 0.0078 15.5 3.0 0.0089 15.3 3.0 1.1 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Lebercilin PF15619.6 ETO12019.1 - 0.025 14.2 7.2 0.032 13.9 7.2 1.1 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease VPS38 PF17649.1 ETO12019.1 - 0.055 12.4 8.6 0.06 12.2 8.6 1.1 1 0 0 1 1 1 0 Vacuolar protein sorting 38 APG6_N PF17675.1 ETO12019.1 - 0.093 13.3 5.6 0.1 13.2 5.6 1.1 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF4407 PF14362.6 ETO12019.1 - 0.37 10.1 4.2 0.42 9.9 4.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2681 PF10883.8 ETO12019.1 - 0.37 11.2 8.5 0.71 10.3 8.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) CENP-H PF05837.12 ETO12019.1 - 0.54 10.7 6.1 0.7 10.3 6.1 1.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF641 PF04859.12 ETO12019.1 - 3.8 7.9 7.8 4.5 7.6 7.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) DUF812 PF05667.11 ETO12019.1 - 3.9 6.2 12.7 4.6 6.0 12.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) MAP17 PF15807.5 ETO12020.1 - 0.0092 16.2 1.3 0.014 15.7 1.3 1.2 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 MAS20 PF02064.15 ETO12020.1 - 0.013 15.6 1.2 0.017 15.2 1.2 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor CRA PF06589.11 ETO12020.1 - 0.014 15.5 6.6 0.029 14.5 6.6 1.6 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Smg8_Smg9 PF10220.9 ETO12020.1 - 0.022 13.1 0.1 0.025 12.9 0.1 1.0 1 0 0 1 1 1 0 Smg8_Smg9 OAD_gamma PF04277.13 ETO12020.1 - 0.18 12.4 0.2 0.44 11.2 0.2 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Macoilin PF09726.9 ETO12021.1 - 0.099 11.2 9.7 0.11 11.0 9.7 1.1 1 0 0 1 1 1 0 Macoilin family LMBR1 PF04791.16 ETO12021.1 - 0.47 9.3 2.3 0.63 8.9 2.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein NST1 PF13945.6 ETO12021.1 - 0.67 10.0 17.4 1.1 9.3 17.4 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator Menin PF05053.13 ETO12021.1 - 1.2 7.4 10.7 1.7 6.9 10.7 1.2 1 0 0 1 1 1 0 Menin CSG2 PF16965.5 ETO12021.1 - 1.6 7.6 3.8 2.2 7.1 3.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4661 PF15576.6 ETO12021.1 - 2.4 8.0 6.9 16 5.3 3.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4661) Presenilin PF01080.17 ETO12021.1 - 5.9 5.6 7.2 8.1 5.1 7.2 1.1 1 0 0 1 1 1 0 Presenilin EST1_DNA_bind PF10373.9 ETO12022.1 - 1.9e-20 73.5 16.1 1.9e-20 73.5 16.1 2.3 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain EST1 PF10374.9 ETO12022.1 - 0.0001 22.9 0.1 0.0001 22.9 0.1 3.7 3 2 0 3 3 3 1 Telomerase activating protein Est1 HSDR_N_2 PF13588.6 ETO12022.1 - 0.079 13.0 0.9 1.7 8.7 0.0 2.7 2 0 0 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) Serinc PF03348.15 ETO12023.1 - 6.8e-57 193.3 23.2 2e-48 165.4 3.8 3.3 2 2 1 3 3 3 2 Serine incorporator (Serinc) Connexin PF00029.19 ETO12024.1 - 0.5 10.1 4.9 0.7 9.6 4.9 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO12024.1 - 3.2 6.4 4.7 3.6 6.3 4.7 1.1 1 0 0 1 1 1 0 Presenilin TPR_12 PF13424.6 ETO12025.1 - 1.5e-31 108.5 0.6 3.8e-09 36.7 0.1 3.3 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12025.1 - 6.5e-20 69.6 11.9 1.1e-05 25.1 0.2 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12025.1 - 1e-19 69.7 0.0 1.8e-05 24.4 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12025.1 - 8.6e-19 66.1 19.3 7.1e-06 25.8 0.6 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12025.1 - 5.1e-16 57.7 21.3 3.5e-05 23.4 0.6 5.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12025.1 - 4.2e-15 54.6 1.0 0.0002 21.2 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12025.1 - 1.4e-07 31.4 5.2 1.2 9.7 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12025.1 - 2.1e-07 31.4 0.0 1.2 9.9 0.0 5.5 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO12025.1 - 1.9e-06 28.1 1.6 0.2 12.4 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO12025.1 - 2.9e-06 27.1 3.2 0.067 13.2 0.2 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12025.1 - 0.00011 22.7 0.0 3.6 8.7 0.0 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO12025.1 - 0.00049 19.9 8.4 0.18 11.6 0.1 3.8 3 1 1 4 4 4 2 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETO12025.1 - 0.00095 18.6 0.0 0.53 9.6 0.0 2.2 2 0 0 2 2 2 2 MalT-like TPR region DUF627 PF04781.12 ETO12025.1 - 0.012 15.6 2.1 0.36 10.9 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF627) TPR_11 PF13414.6 ETO12025.1 - 0.027 14.2 16.6 1 9.1 0.2 7.1 8 0 0 8 8 8 0 TPR repeat OrfA PF17495.2 ETO12025.1 - 0.065 13.4 0.0 9.9 6.4 0.0 3.4 1 1 3 4 4 4 0 Vpr-like OrfA ANAPC3 PF12895.7 ETO12025.1 - 0.071 13.3 11.4 2.6 8.4 0.2 3.7 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 ETO12025.1 - 0.076 12.5 0.9 0.87 9.0 0.1 2.1 1 1 1 2 2 2 0 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETO12025.1 - 5.2 7.2 9.5 2.3 8.3 0.3 4.0 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Kelch_6 PF13964.6 ETO12026.1 - 5.3e-07 29.7 4.8 0.0011 19.1 0.1 4.9 5 1 1 6 6 6 2 Kelch motif Kelch_5 PF13854.6 ETO12026.1 - 4.5e-05 23.3 6.9 0.096 12.7 0.2 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO12026.1 - 0.00013 21.9 3.1 0.0018 18.3 0.1 3.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO12026.1 - 0.00022 21.4 3.1 0.00076 19.7 0.1 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO12026.1 - 0.0027 17.3 3.7 1.2 8.7 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Ribosomal_60s PF00428.19 ETO12027.1 - 6.6e-14 52.3 15.6 3e-13 50.2 15.6 1.8 1 1 0 1 1 1 1 60s Acidic ribosomal protein Jag_N PF14804.6 ETO12027.1 - 0.013 15.8 0.1 0.03 14.6 0.0 1.6 2 0 0 2 2 2 0 Jag N-terminus WD40 PF00400.32 ETO12028.1 - 7.7e-52 172.1 19.7 1.9e-10 41.1 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12028.1 - 2e-19 69.7 2.0 0.0007 19.9 0.0 5.6 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12028.1 - 1e-15 57.5 4.0 0.022 13.8 0.0 6.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO12028.1 - 1.5e-10 41.3 2.8 9.7e-05 22.3 0.5 2.8 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12028.1 - 3.3e-06 26.9 8.3 5.8 7.0 0.1 6.3 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO12028.1 - 4.5e-06 25.6 3.4 0.26 9.9 0.1 3.5 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12028.1 - 4.7e-06 26.2 1.4 0.035 13.4 0.1 3.5 2 2 1 3 3 3 2 WD40-like domain DUF5570 PF17731.1 ETO12028.1 - 0.0001 22.4 6.9 7.3 6.7 0.0 4.9 1 1 4 5 5 5 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO12028.1 - 0.0051 16.2 3.2 7.9 5.7 0.0 4.4 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO12028.1 - 0.036 12.8 0.2 1.7 7.3 0.0 3.2 2 1 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cytochrom_D1 PF02239.16 ETO12028.1 - 0.046 12.3 0.1 2.4 6.6 0.0 2.7 2 1 1 3 3 3 0 Cytochrome D1 heme domain BBS2_Mid PF14783.6 ETO12028.1 - 0.15 12.1 1.4 25 4.9 0.0 3.9 3 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO12029.1 - 9.9e-50 165.5 14.4 2.8e-08 34.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12029.1 - 7.2e-16 58.3 3.1 0.02 15.2 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12029.1 - 1.4e-13 50.6 1.0 0.014 14.3 0.0 5.8 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Str_synth PF03088.16 ETO12029.1 - 5.5e-08 32.8 0.1 1.2 9.3 0.0 4.5 3 2 1 4 4 4 4 Strictosidine synthase eIF2A PF08662.11 ETO12029.1 - 5.1e-07 29.8 0.6 0.028 14.3 0.1 3.2 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12029.1 - 6.4e-06 26.0 8.4 4.3 7.4 0.0 6.4 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO12029.1 - 2.2e-05 23.3 7.9 0.95 8.0 0.1 4.9 1 1 4 5 5 5 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO12029.1 - 0.0032 16.9 1.1 0.028 13.7 0.3 2.7 1 1 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO12029.1 - 0.036 14.2 0.1 18 5.5 0.0 3.7 3 1 1 4 4 4 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO12029.1 - 0.048 12.2 0.2 0.73 8.3 0.0 2.5 1 1 1 3 3 3 0 Cytochrome D1 heme domain SBD PF17882.1 ETO12029.1 - 0.17 11.7 0.5 40 4.0 0.0 3.1 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain TPR_12 PF13424.6 ETO12030.1 - 1.1e-19 70.5 2.3 2.7e-10 40.4 0.1 3.1 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12030.1 - 3.7e-12 45.7 0.2 5.4e-05 22.9 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12030.1 - 9e-11 41.0 0.6 6.5e-05 22.7 0.0 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12030.1 - 1.8e-09 37.0 14.6 1.8e-06 27.5 0.6 4.3 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12030.1 - 9.1e-09 34.9 14.0 2e-05 24.4 0.5 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12030.1 - 2.1e-06 27.4 7.4 0.0086 16.1 0.4 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12030.1 - 0.0019 18.5 2.3 0.08 13.4 0.1 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO12030.1 - 0.009 16.1 3.5 3.5 7.8 0.1 3.1 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO12030.1 - 0.016 16.0 0.1 0.41 11.6 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO12030.1 - 0.031 14.9 1.4 20 6.1 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12030.1 - 0.082 13.6 0.0 0.22 12.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO12030.1 - 0.23 11.1 8.2 0.5 10.1 0.1 3.8 3 1 1 4 4 4 0 TPR repeat Spc24 PF08286.11 ETO12034.1 - 0.0056 16.9 0.3 0.0093 16.2 0.1 1.5 1 1 0 1 1 1 1 Spc24 subunit of Ndc80 Helicase_C PF00271.31 ETO12035.1 - 0.015 15.6 0.1 0.052 13.9 0.1 2.1 1 0 0 1 1 1 0 Helicase conserved C-terminal domain VWA_2 PF13519.6 ETO12035.1 - 0.022 15.4 0.0 0.068 13.8 0.0 1.8 2 0 0 2 2 2 0 von Willebrand factor type A domain CENP-M PF11111.8 ETO12036.1 - 0.02 14.1 0.2 0.04 13.1 0.2 1.4 1 0 0 1 1 1 0 Centromere protein M (CENP-M) FAD_binding_8 PF08022.12 ETO12037.1 - 0.051 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 FAD-binding domain Ras PF00071.22 ETO12039.1 - 3.7e-15 55.9 0.1 3.3e-13 49.5 0.1 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO12039.1 - 3.1e-14 53.2 0.4 5.6e-12 45.9 0.4 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO12039.1 - 9.1e-05 22.5 0.6 0.00017 21.6 0.6 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ETO12039.1 - 0.00041 19.9 0.2 0.082 12.3 0.2 2.2 1 1 1 2 2 2 2 ADP-ribosylation factor family AAA_14 PF13173.6 ETO12039.1 - 0.019 15.0 0.1 0.029 14.4 0.1 1.3 1 0 0 1 1 1 0 AAA domain MobB PF03205.14 ETO12039.1 - 0.033 14.1 0.2 0.2 11.5 0.0 2.0 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B ABC_tran PF00005.27 ETO12039.1 - 0.043 14.3 0.1 0.05 14.1 0.1 1.2 1 0 0 1 1 1 0 ABC transporter AAA_22 PF13401.6 ETO12039.1 - 0.055 13.8 0.3 0.13 12.5 0.3 1.7 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ETO12039.1 - 0.075 12.4 0.9 0.36 10.2 0.0 2.0 1 1 0 2 2 2 0 Bacterial TniB protein AAA PF00004.29 ETO12039.1 - 0.096 13.1 0.1 0.18 12.2 0.1 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) zf-RanBP PF00641.18 ETO12041.1 - 5e-07 28.9 1.9 1e-06 27.9 1.9 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others TFIIA PF03153.13 ETO12042.1 - 0.17 11.9 15.0 0.059 13.4 7.8 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit GOLD_2 PF13897.6 ETO12042.1 - 0.36 11.3 2.4 12 6.4 0.2 2.5 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking DUF2052 PF09747.9 ETO12042.1 - 3.3 7.8 15.7 0.56 10.3 0.5 2.7 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) SAM_1 PF00536.30 ETO12044.1 - 1.3e-11 44.7 0.1 2.6e-11 43.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO12044.1 - 2.1e-09 37.4 0.1 4e-09 36.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CDC45 PF02724.14 ETO12044.1 - 0.00054 18.4 13.8 0.00074 17.9 13.8 1.1 1 0 0 1 1 1 1 CDC45-like protein Zip PF02535.22 ETO12044.1 - 0.0016 17.7 2.5 0.0022 17.3 2.5 1.2 1 0 0 1 1 1 1 ZIP Zinc transporter Presenilin PF01080.17 ETO12044.1 - 0.0057 15.5 9.4 0.0078 15.0 9.4 1.2 1 0 0 1 1 1 1 Presenilin RR_TM4-6 PF06459.12 ETO12044.1 - 0.013 15.3 17.1 0.021 14.6 17.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec10 PF07393.11 ETO12044.1 - 0.017 13.6 14.6 0.027 12.9 14.6 1.3 1 0 0 1 1 1 0 Exocyst complex component Sec10 DDHD PF02862.17 ETO12044.1 - 0.046 13.9 8.9 0.088 13.0 8.9 1.5 1 0 0 1 1 1 0 DDHD domain L_biotic_typeA PF04604.13 ETO12044.1 - 0.1 12.5 0.0 0.28 11.1 0.0 1.7 1 0 0 1 1 1 0 Type-A lantibiotic DUF3807 PF12720.7 ETO12044.1 - 0.34 11.2 23.8 0.72 10.1 23.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DUF4228 PF14009.6 ETO12044.1 - 0.74 10.2 10.5 1.6 9.1 10.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) HCO3_cotransp PF00955.21 ETO12044.1 - 1.3 7.8 5.9 2.1 7.0 5.8 1.3 1 1 0 1 1 1 0 HCO3- transporter family MDM10 PF12519.8 ETO12044.1 - 1.9 7.3 12.8 2.6 6.8 12.8 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 AAA_11 PF13086.6 ETO12044.1 - 2.5 7.8 17.6 5.2 6.8 17.6 1.6 1 0 0 1 1 1 0 AAA domain LMBR1 PF04791.16 ETO12044.1 - 3.5 6.4 9.7 5.3 5.8 9.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein PPL5 PF18168.1 ETO12044.1 - 5.2 6.3 16.5 9.8 5.4 16.5 1.5 1 0 0 1 1 1 0 Prim-pol family 5 Ndc1_Nup PF09531.10 ETO12044.1 - 5.2 5.6 12.6 8.7 4.9 12.6 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Peroxin-13_N PF04088.13 ETO12044.1 - 5.4 7.3 16.8 1.1e+02 3.1 0.0 2.8 2 1 0 2 2 2 0 Peroxin 13, N-terminal region SOBP PF15279.6 ETO12044.1 - 7.4 7.1 14.7 3.4 8.2 12.6 1.5 2 0 0 2 2 2 0 Sine oculis-binding protein DUF5630 PF18632.1 ETO12046.1 - 0.0091 15.3 0.2 0.012 14.9 0.2 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5630) SQHop_cyclase_C PF13243.6 ETO12046.1 - 0.022 13.9 0.1 0.043 12.9 0.0 1.5 1 1 1 2 2 2 0 Squalene-hopene cyclase C-terminal domain ETRAMP PF09716.10 ETO12047.1 - 0.21 11.7 3.3 0.15 12.1 1.3 2.0 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4653 PF15546.6 ETO12047.1 - 1.4 8.5 5.2 0.37 10.4 2.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4653) CRAL_TRIO PF00650.20 ETO12048.1 - 0.12 12.1 0.1 0.37 10.5 0.0 1.9 2 0 0 2 2 2 0 CRAL/TRIO domain THEG4 PF15834.5 ETO12048.1 - 1.7 8.6 3.7 0.61 10.1 0.3 1.8 2 0 0 2 2 2 0 Testis highly expressed protein 4 DUF4320 PF14208.6 ETO12049.1 - 0.021 14.9 1.3 4.1 7.5 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4320) Allexi_40kDa PF05549.11 ETO12049.1 - 0.42 10.1 4.4 2.9 7.4 0.0 2.3 1 1 1 2 2 2 0 Allexivirus 40kDa protein RsgA_GTPase PF03193.16 ETO12050.1 - 0.00011 22.2 0.6 0.0021 18.0 0.2 3.4 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO12050.1 - 0.0015 18.6 0.1 0.0015 18.6 0.1 3.8 4 1 0 4 4 3 1 50S ribosome-binding GTPase Apolipoprotein PF01442.18 ETO12050.1 - 0.0043 16.9 1.3 0.0043 16.9 1.3 6.7 7 1 1 8 8 7 3 Apolipoprotein A1/A4/E domain ABC_tran PF00005.27 ETO12050.1 - 0.037 14.5 0.0 0.037 14.5 0.0 7.1 7 1 1 8 8 8 0 ABC transporter PhoH PF02562.16 ETO12050.1 - 0.039 13.4 0.1 0.039 13.4 0.1 2.7 3 0 0 3 3 3 0 PhoH-like protein AAA_29 PF13555.6 ETO12050.1 - 0.062 13.1 0.1 0.18 11.6 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_19 PF13245.6 ETO12050.1 - 0.12 12.7 0.1 0.12 12.7 0.1 3.5 3 0 0 3 3 3 0 AAA domain AAA_28 PF13521.6 ETO12050.1 - 0.6 10.3 3.7 0.5 10.6 0.1 2.9 3 0 0 3 3 3 0 AAA domain CX9C PF16860.5 ETO12050.1 - 0.87 9.6 8.3 0.23 11.5 3.9 2.4 2 0 0 2 2 2 0 CHCH-CHCH-like Cx9C, IMS import disulfide relay-system, ZZ PF00569.17 ETO12050.1 - 0.87 9.4 5.4 0.17 11.7 1.0 2.1 2 0 0 2 2 2 0 Zinc finger, ZZ type PduV-EutP PF10662.9 ETO12050.1 - 1.2 8.9 7.9 3.9 7.2 0.1 4.7 3 1 1 4 4 4 0 Ethanolamine utilisation - propanediol utilisation DUF1016_N PF17761.1 ETO12050.1 - 2.3 8.4 11.5 1.8 8.7 1.3 4.0 3 0 0 3 3 3 0 DUF1016 N-terminal domain Methyltransf_12 PF08242.12 ETO12050.1 - 3.6 8.4 4.6 99 3.8 0.2 4.7 3 0 0 3 3 3 0 Methyltransferase domain ATP-grasp_4 PF13535.6 ETO12050.1 - 4.9 6.7 8.0 1 9.0 0.0 3.8 4 0 0 4 4 4 0 ATP-grasp domain Connexin PF00029.19 ETO12051.1 - 0.49 10.1 6.2 1.6 8.4 2.0 2.1 2 0 0 2 2 2 0 Connexin Peptidase_S49_N PF08496.10 ETO12051.1 - 3.6 7.7 12.1 0.56 10.3 7.3 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal WD40 PF00400.32 ETO12052.1 - 0.04 14.8 0.1 0.12 13.3 0.1 1.8 1 0 0 1 1 1 0 WD domain, G-beta repeat Pinin_SDK_memA PF04696.13 ETO12053.1 - 3.4 7.7 35.8 0.32 11.1 19.2 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Pinin_SDK_memA PF04696.13 ETO12054.1 - 1.6 8.8 37.4 0.32 11.0 19.2 2.2 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region Acyl_transf_1 PF00698.21 ETO12055.1 - 2.7e-11 43.6 0.0 1.5e-06 28.0 0.0 3.0 1 1 1 2 2 2 2 Acyl transferase domain KH_1 PF00013.29 ETO12055.1 - 0.0064 16.3 3.7 0.012 15.4 3.7 1.4 1 0 0 1 1 1 1 KH domain SAT PF16073.5 ETO12055.1 - 0.0081 15.9 0.0 0.045 13.5 0.0 2.1 2 1 1 3 3 3 1 Starter unit:ACP transacylase in aflatoxin biosynthesis Tsi6 PF18660.1 ETO12055.1 - 0.032 14.3 0.1 0.14 12.2 0.0 2.1 2 0 0 2 2 2 0 Tsi6 FAD_SOX PF18371.1 ETO12055.1 - 0.052 13.9 0.4 19 5.7 0.0 3.2 2 1 1 3 3 3 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase DUF3236 PF11576.8 ETO12055.1 - 4.1 7.1 12.3 0.98 9.1 4.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3236) Dynactin_p62 PF05502.13 ETO12056.1 - 0.011 14.6 0.9 0.013 14.3 0.1 1.5 1 1 1 2 2 2 0 Dynactin p62 family Sporozoite_P67 PF05642.11 ETO12056.1 - 0.03 12.4 2.0 0.041 12.0 2.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TFIIA PF03153.13 ETO12056.1 - 0.26 11.2 8.1 0.45 10.4 8.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.10 ETO12056.1 - 3.3 8.2 12.2 7 7.1 12.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO12056.1 - 5.9 4.9 8.6 8.7 4.3 8.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ETO12058.1 - 1e-07 32.5 6.9 9.7e-06 26.2 0.4 3.5 4 1 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO12058.1 - 0.0027 16.4 0.7 0.088 11.4 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 TPR_12 PF13424.6 ETO12059.1 - 2e-16 60.0 0.0 9.7e-08 32.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12059.1 - 5.5e-13 48.0 9.9 5.8e-07 29.2 1.6 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12059.1 - 8e-13 47.6 13.5 1.7e-06 27.6 0.1 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12059.1 - 3.7e-10 39.3 0.2 2.9e-06 27.0 0.0 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12059.1 - 9.9e-08 31.5 11.5 0.00019 21.3 1.9 3.1 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12059.1 - 1.4e-06 27.9 0.6 0.1 12.7 0.1 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12059.1 - 4.9e-05 23.4 1.6 0.94 10.0 0.0 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat Kelch_5 PF13854.6 ETO12059.1 - 0.00028 20.8 0.3 0.0056 16.6 0.1 2.8 2 0 0 2 2 2 1 Kelch motif TPR_14 PF13428.6 ETO12059.1 - 0.00031 21.3 0.0 0.021 15.6 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12059.1 - 0.0011 19.5 0.0 0.58 10.9 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO12059.1 - 0.0015 18.3 2.7 0.96 9.2 0.1 2.7 1 1 1 2 2 2 2 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO12059.1 - 0.0049 17.4 2.8 0.24 12.1 1.2 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETO12059.1 - 0.021 14.9 2.4 0.68 10.0 0.2 3.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO12059.1 - 0.049 13.3 9.5 0.11 12.2 0.1 3.6 3 1 1 4 4 4 0 TPR repeat RPN6_N PF18055.1 ETO12059.1 - 0.13 12.6 3.9 4.2 7.8 0.2 2.8 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain ANAPC3 PF12895.7 ETO12059.1 - 0.22 11.8 3.5 1.5 9.1 3.4 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 CTNNBL PF08216.11 ETO12060.1 - 0.036 14.2 0.8 0.12 12.5 0.1 2.0 1 1 0 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear Phage_terminase PF10668.9 ETO12060.1 - 0.61 10.1 9.0 0.065 13.2 2.5 2.6 2 1 1 3 3 3 0 Phage terminase small subunit LRR_6 PF13516.6 ETO12062.1 - 1.6e-12 46.4 21.3 6e-05 22.8 0.0 7.2 7 0 0 7 7 7 4 Leucine Rich repeat LRR_8 PF13855.6 ETO12062.1 - 4.2e-05 23.2 12.1 0.011 15.5 0.0 4.9 3 1 1 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 ETO12062.1 - 0.00014 22.2 1.6 0.032 14.7 0.0 4.9 4 1 3 7 7 7 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO12062.1 - 0.012 16.1 8.8 9.1 7.3 0.0 5.4 6 0 0 6 6 6 0 Leucine Rich Repeat EamA PF00892.20 ETO12063.1 - 4e-16 59.4 34.3 2.3e-08 34.3 16.5 3.0 3 0 0 3 3 3 2 EamA-like transporter family TPT PF03151.16 ETO12063.1 - 0.015 14.6 1.5 0.015 14.6 1.5 2.3 2 0 0 2 2 2 0 Triose-phosphate Transporter family FAM176 PF14851.6 ETO12063.1 - 0.023 14.4 0.2 0.023 14.4 0.2 3.0 4 0 0 4 4 4 0 FAM176 family PBP1_TM PF14812.6 ETO12063.1 - 2.6 8.5 8.0 1.6 9.1 1.5 2.7 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PE-PPE PF08237.11 ETO12064.1 - 0.099 12.2 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 PE-PPE domain CrgA PF06781.12 ETO12067.1 - 0.0031 17.5 1.0 0.86 9.7 0.0 2.4 2 0 0 2 2 2 2 Cell division protein CrgA AP3D1 PF06375.11 ETO12068.1 - 2.8 8.1 17.2 0.056 13.7 6.8 2.1 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Utp14 PF04615.13 ETO12069.1 - 0.00095 17.9 34.4 0.0015 17.3 34.4 1.2 1 0 0 1 1 1 1 Utp14 protein Spt5_N PF11942.8 ETO12069.1 - 4.9 8.2 21.9 1.3 10.1 14.9 2.7 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal SPRY PF00622.28 ETO12070.1 - 0.064 13.4 0.1 0.11 12.6 0.1 1.5 1 0 0 1 1 1 0 SPRY domain Glyco_transf_49 PF13896.6 ETO12072.1 - 2.1e-14 53.6 0.1 2.6e-14 53.4 0.1 1.2 1 0 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 ETO12072.1 - 0.0033 17.2 0.1 0.0062 16.4 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ETO12072.1 - 0.028 13.9 0.0 0.035 13.6 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 WD40 PF00400.32 ETO12073.1 - 3.6e-38 128.9 16.3 6.8e-06 26.7 1.0 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO12073.1 - 5.5e-10 38.5 10.0 0.011 14.5 0.3 5.3 1 1 4 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO12073.1 - 2.4e-08 34.2 4.5 0.6 10.4 0.0 5.9 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO12074.1 - 5.7e-135 435.2 64.9 9e-10 39.0 2.0 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12074.1 - 6.3e-30 103.3 21.4 0.0025 18.1 0.0 13.1 1 1 12 14 14 14 12 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12074.1 - 9e-22 77.5 9.6 0.03 13.3 0.0 12.3 1 1 10 12 12 12 9 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12074.1 - 3.1e-14 53.0 14.9 0.0024 17.3 0.1 7.5 3 2 2 7 7 7 6 WD40-like domain Pentapeptide PF00805.22 ETO12074.1 - 3.6e-08 32.9 1.7 7.1e-08 32.0 1.7 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DUF727 PF05303.12 ETO12074.1 - 7.4e-06 26.0 4.2 5.4 7.1 0.0 7.8 6 4 3 9 9 9 1 Protein of unknown function (DUF727) Pentapeptide_4 PF13599.6 ETO12074.1 - 8.3e-05 22.7 0.1 0.00034 20.7 0.1 2.1 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO12074.1 - 0.0003 19.4 6.3 1.7 7.1 0.3 5.1 4 2 2 6 6 6 2 Cytochrome D1 heme domain Mid2 PF04478.12 ETO12074.1 - 0.00036 20.4 11.8 5.1 6.9 0.1 7.4 7 3 2 9 9 9 1 Mid2 like cell wall stress sensor SGL PF08450.12 ETO12074.1 - 0.00038 20.1 0.7 3.8 7.0 0.0 4.8 5 0 0 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region Pentapeptide_3 PF13576.6 ETO12074.1 - 0.016 15.3 0.8 0.047 13.9 0.1 2.2 2 0 0 2 2 1 0 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO12074.1 - 0.02 15.0 0.4 62 3.8 0.0 5.6 7 1 1 8 8 7 0 Domain of unknown function (DUF3475) Spc29 PF17082.5 ETO12074.1 - 1.3 8.8 6.2 23 4.7 0.1 4.6 2 2 0 3 3 3 0 Spindle Pole Component 29 PD40 PF07676.12 ETO12074.1 - 2.5 8.2 16.2 31 4.7 0.1 7.5 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO12076.1 - 9.1e-44 146.6 23.5 4.7e-07 30.4 0.0 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12076.1 - 1.7e-11 44.3 1.5 0.11 12.8 0.0 5.9 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12076.1 - 5.5e-10 38.5 5.1 0.025 13.2 0.5 5.8 1 1 3 5 5 5 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO12076.1 - 1.5e-06 28.8 3.4 1.5e-06 28.8 3.4 3.2 2 1 1 3 3 3 1 TRAF-type zinc finger Auxin_canalis PF05703.11 ETO12076.1 - 0.68 9.8 1.4 1.3 8.9 1.4 1.4 1 0 0 1 1 1 0 Auxin canalisation PIG-S PF10510.9 ETO12076.1 - 1.7 7.4 8.2 0.15 10.8 3.7 1.6 2 0 0 2 2 2 0 Phosphatidylinositol-glycan biosynthesis class S protein LMBR1 PF04791.16 ETO12076.1 - 2.6 6.8 12.6 3.8 6.3 12.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-TRAF_2 PF15965.5 ETO12076.1 - 4.1 7.9 12.5 6.6 7.3 0.9 3.5 2 1 1 3 3 3 0 TRAF-like zinc-finger Peptidase_C14 PF00656.22 ETO12077.1 - 3.8e-14 53.2 1.8 3.8e-14 53.2 1.8 2.1 2 0 0 2 2 2 1 Caspase domain Kelch_4 PF13418.6 ETO12077.1 - 0.00021 21.2 1.4 0.0072 16.3 0.0 3.9 4 1 1 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO12077.1 - 0.00074 19.4 0.1 0.081 12.9 0.2 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO12077.1 - 0.053 13.1 0.2 1.8 8.2 0.0 3.5 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO12077.1 - 0.063 13.6 0.6 15 6.0 0.1 3.8 4 0 0 4 4 4 0 Kelch motif HATPase_c PF02518.26 ETO12077.1 - 0.13 12.7 0.7 3 8.4 0.1 2.6 1 1 0 2 2 2 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Pro_CA PF00484.19 ETO12077.1 - 1.7 8.9 5.6 2.2 8.5 2.9 2.5 2 0 0 2 2 2 0 Carbonic anhydrase HMG_box PF00505.19 ETO12078.1 - 9.6e-07 29.1 0.8 9.6e-07 29.1 0.8 3.0 3 0 0 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETO12078.1 - 2.7e-06 27.9 2.4 2.7e-06 27.9 2.4 3.2 2 1 1 3 3 3 1 HMG-box domain Cas_Csa5 PF09702.10 ETO12079.1 - 0.00074 19.7 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csa5) YkyB PF14177.6 ETO12079.1 - 0.011 16.0 0.1 0.027 14.7 0.1 1.6 1 0 0 1 1 1 0 YkyB-like protein CSG2 PF16965.5 ETO12081.1 - 0.0015 17.6 0.5 0.0015 17.6 0.5 3.0 3 0 0 3 3 3 1 Ceramide synthase regulator Connexin PF00029.19 ETO12081.1 - 0.12 12.1 0.0 0.12 12.1 0.0 3.4 3 1 0 3 3 3 0 Connexin LapA_dom PF06305.11 ETO12082.1 - 0.36 10.7 3.3 0.84 9.5 3.3 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Sigma_reg_N PF13800.6 ETO12082.1 - 9.1 6.6 5.9 16 5.8 2.4 2.6 3 0 0 3 3 3 0 Sigma factor regulator N-terminal Ribosomal_L33 PF00471.20 ETO12083.1 - 0.076 13.5 0.3 0.076 13.5 0.3 2.0 2 0 0 2 2 2 0 Ribosomal protein L33 Zip PF02535.22 ETO12085.1 - 4.2 6.5 5.8 0.66 9.1 0.1 2.1 1 1 1 2 2 2 0 ZIP Zinc transporter Protamine_like PF06382.11 ETO12087.1 - 0.064 13.4 0.2 0.12 12.6 0.2 1.4 1 0 0 1 1 1 0 Protamine and protamine like SecA_DEAD PF07517.14 ETO12088.1 - 1.2e-07 31.3 0.1 2.1e-07 30.5 0.1 1.4 1 0 0 1 1 1 1 SecA DEAD-like domain AAA PF00004.29 ETO12088.1 - 0.061 13.8 0.0 0.81 10.1 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF3644 PF12358.8 ETO12088.1 - 0.084 13.4 0.6 0.26 11.8 0.6 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF3644) Baculo_PEP_C PF04513.12 ETO12089.1 - 0.029 14.4 0.7 0.057 13.5 0.7 1.5 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus HEAT PF02985.22 ETO12092.1 - 3.3e-15 54.9 6.1 0.45 10.9 0.0 10.8 12 0 0 12 12 12 4 HEAT repeat HEAT_2 PF13646.6 ETO12092.1 - 7.8e-13 48.6 0.0 0.03 14.7 0.0 6.4 5 2 3 8 8 8 4 HEAT repeats HEAT_EZ PF13513.6 ETO12092.1 - 1.6e-09 38.0 0.0 5.1 7.7 0.0 8.8 9 1 1 10 10 10 2 HEAT-like repeat Cnd1 PF12717.7 ETO12092.1 - 4.4e-06 26.8 34.0 0.0018 18.3 0.5 6.9 3 3 2 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO12092.1 - 0.00045 20.8 24.3 0.022 15.4 0.1 7.7 5 2 3 8 8 8 1 Vacuolar 14 Fab1-binding region Ank_3 PF13606.6 ETO12092.1 - 0.0058 17.0 0.1 0.12 13.0 0.0 3.3 1 1 1 2 2 2 1 Ankyrin repeat RTP1_C1 PF10363.9 ETO12092.1 - 0.0059 16.8 9.6 14 5.9 0.0 6.3 4 1 1 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO12092.1 - 0.17 12.6 0.1 2.4e+02 2.9 0.0 4.5 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat DNA_alkylation PF08713.11 ETO12092.1 - 0.69 9.6 6.6 4.4 7.0 0.2 3.6 4 1 0 4 4 4 0 DNA alkylation repair enzyme FPL PF09758.9 ETO12092.1 - 2.4 8.2 27.1 0.18 11.8 3.1 6.5 4 1 1 5 5 5 0 Uncharacterised conserved protein BP28CT PF08146.12 ETO12092.1 - 3 7.7 15.5 0.2 11.5 0.2 5.5 5 1 1 6 6 6 0 BP28CT (NUC211) domain WD40 PF00400.32 ETO12094.1 - 4.6e-51 169.7 7.4 1.1e-10 41.9 0.0 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12094.1 - 1.5e-15 57.3 0.1 0.013 15.8 0.0 5.7 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12094.1 - 6.9e-11 41.7 0.1 0.0051 15.8 0.0 4.9 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12094.1 - 0.00015 21.2 0.1 0.42 9.9 0.0 3.9 3 1 1 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO12094.1 - 0.0004 20.2 5.3 10 6.2 0.1 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO12094.1 - 0.0022 16.6 0.0 0.019 13.5 0.0 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO12094.1 - 0.0077 14.9 0.2 5.1 5.6 0.0 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO12094.1 - 0.016 14.6 0.1 5.6 6.2 0.0 2.7 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Kelch_3 PF13415.6 ETO12094.1 - 0.066 13.5 0.1 0.64 10.4 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Me-amine-dh_H PF06433.11 ETO12094.1 - 0.078 11.8 0.0 0.25 10.2 0.0 1.9 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Kelch_6 PF13964.6 ETO12094.1 - 0.12 12.7 0.5 3.8 7.9 0.0 3.4 3 0 0 3 3 3 0 Kelch motif ABC_tran PF00005.27 ETO12095.1 - 3.5e-29 102.1 0.0 5.2e-29 101.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO12095.1 - 6.2e-09 35.6 0.0 1.1e-06 28.3 0.0 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain DUF87 PF01935.17 ETO12095.1 - 0.00015 22.0 0.0 0.00026 21.2 0.0 1.4 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_16 PF13191.6 ETO12095.1 - 0.00026 21.4 0.1 0.00063 20.2 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO12095.1 - 0.0013 19.0 0.0 0.0096 16.2 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ETO12095.1 - 0.0016 18.1 0.1 0.0042 16.8 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_24 PF13479.6 ETO12095.1 - 0.0023 17.7 0.0 0.0057 16.4 0.0 1.7 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ETO12095.1 - 0.0033 16.7 0.0 0.0074 15.6 0.0 1.5 2 0 0 2 2 2 1 Zeta toxin AAA_30 PF13604.6 ETO12095.1 - 0.0097 15.6 0.0 0.097 12.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETO12095.1 - 0.017 14.6 0.0 0.03 13.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA PF00004.29 ETO12095.1 - 0.019 15.4 0.0 3.1 8.2 0.0 2.3 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ETO12095.1 - 0.026 14.6 0.0 0.08 13.0 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ETO12095.1 - 0.046 13.5 0.0 0.24 11.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Ploopntkinase3 PF18751.1 ETO12095.1 - 0.046 13.6 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 RsgA_GTPase PF03193.16 ETO12095.1 - 0.075 12.9 0.0 0.16 11.9 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase Septin PF00735.18 ETO12095.1 - 0.075 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Septin NACHT PF05729.12 ETO12095.1 - 0.075 12.9 0.0 0.96 9.3 0.0 2.2 2 0 0 2 2 2 0 NACHT domain NTPase_1 PF03266.15 ETO12095.1 - 0.077 12.9 0.0 0.2 11.5 0.0 1.7 1 0 0 1 1 1 0 NTPase AAA_5 PF07728.14 ETO12095.1 - 0.12 12.4 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_membrane PF00664.23 ETO12096.1 - 2.7e-42 145.3 0.7 3.3e-42 145.0 0.7 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region Abhydrolase_6 PF12697.7 ETO12096.1 - 0.0041 17.8 0.0 0.0047 17.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Ras PF00071.22 ETO12100.1 - 6.1e-29 100.7 0.0 9.1e-19 67.6 0.0 3.3 2 1 1 3 3 3 3 Ras family Roc PF08477.13 ETO12100.1 - 5.6e-18 65.3 0.0 5.5e-11 42.7 0.0 2.8 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO12100.1 - 5.9e-05 22.6 0.0 0.0024 17.4 0.0 2.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO12100.1 - 0.00095 19.2 3.2 0.12 12.5 0.0 3.4 2 2 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ETO12100.1 - 0.0036 17.7 0.0 0.0057 17.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO12100.1 - 0.0048 16.8 0.0 0.018 15.0 0.0 2.0 1 0 0 1 1 1 1 RsgA GTPase Septin PF00735.18 ETO12100.1 - 0.0093 15.3 0.8 0.016 14.5 0.0 1.8 2 0 0 2 2 2 1 Septin AAA_22 PF13401.6 ETO12100.1 - 0.022 15.0 0.0 0.049 13.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ETO12100.1 - 0.035 13.9 0.0 0.071 12.9 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ETO12100.1 - 0.057 13.3 0.1 0.1 12.5 0.1 1.4 1 0 0 1 1 1 0 NACHT domain TT_ORF2 PF02957.15 ETO12100.1 - 0.08 13.9 1.3 0.17 12.8 1.3 1.5 1 0 0 1 1 1 0 TT viral ORF2 DUF463 PF04317.12 ETO12100.1 - 0.087 11.7 0.3 0.54 9.1 0.0 2.1 2 0 0 2 2 2 0 YcjX-like family, DUF463 CKAP2_C PF15297.6 ETO12100.1 - 0.24 10.4 7.6 0.057 12.5 1.0 2.0 2 0 0 2 2 2 0 Cytoskeleton-associated protein 2 C-terminus U-box PF04564.15 ETO12101.1 - 9.1e-12 45.0 0.2 2.4e-11 43.6 0.2 1.8 1 0 0 1 1 1 1 U-box domain F-box PF00646.33 ETO12101.1 - 0.0069 16.2 0.7 0.017 15.0 0.7 1.7 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO12101.1 - 0.023 14.6 0.8 0.023 14.6 0.8 1.8 2 0 0 2 2 2 0 F-box-like DEPP PF15343.6 ETO12101.1 - 0.028 14.5 0.5 0.079 13.0 0.1 1.9 2 0 0 2 2 2 0 Decidual protein induced by progesterone family F-box_4 PF15966.5 ETO12101.1 - 0.041 13.8 0.9 0.093 12.6 0.9 1.7 1 1 0 1 1 1 0 F-box PolyA_pol PF01743.20 ETO12103.1 - 0.0077 16.7 2.6 0.0095 16.4 2.6 1.1 1 0 0 1 1 1 1 Poly A polymerase head domain Glucokinase PF02685.16 ETO12103.1 - 0.015 14.3 1.2 0.018 14.1 1.2 1.0 1 0 0 1 1 1 0 Glucokinase DUF3491 PF11996.8 ETO12103.1 - 0.019 12.8 2.0 0.022 12.6 2.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3491) Glyco_transf_36 PF06165.11 ETO12104.1 - 0.01 15.2 4.4 0.015 14.7 4.4 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 36 Kelch_2 PF07646.15 ETO12105.1 - 4.5e-07 29.6 5.2 0.00069 19.5 0.4 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO12105.1 - 2.7e-06 27.5 3.0 0.28 11.5 0.5 3.8 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 ETO12105.1 - 0.00015 21.7 2.3 2 8.5 1.7 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO12105.1 - 0.00075 19.0 3.2 0.083 12.5 1.1 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO12105.1 - 0.0039 17.2 0.2 2.5 8.2 0.1 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain CxC4 PF18717.1 ETO12106.1 - 0.14 12.0 0.8 0.18 11.6 0.8 1.1 1 0 0 1 1 1 0 CxC4 like cysteine cluster associated with KDZ transposases PYST-C1 PF09690.10 ETO12110.1 - 0.0026 17.4 3.3 0.0069 16.1 3.3 1.8 1 0 0 1 1 1 1 Plasmodium yoelii subtelomeric region (PYST-C1) DUF2779 PF11074.8 ETO12110.1 - 0.0032 17.9 3.1 0.004 17.6 3.1 1.4 1 1 0 1 1 1 1 Domain of unknown function(DUF2779) Fer2_BFD PF04324.15 ETO12112.1 - 0.036 14.4 0.2 6.8 7.1 0.1 2.5 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain NinF PF05810.12 ETO12112.1 - 0.1 12.5 1.7 0.13 12.1 0.2 2.0 2 0 0 2 2 2 0 NinF protein Cas_CXXC_CXXC PF09706.10 ETO12112.1 - 0.19 12.0 6.5 12 6.2 2.6 3.4 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_CXXC_CXXC) VWA_3 PF13768.6 ETO12113.1 - 0.016 15.1 0.0 0.032 14.2 0.0 1.5 2 0 0 2 2 2 0 von Willebrand factor type A domain LTD PF00932.19 ETO12114.1 - 0.027 14.8 0.6 0.22 11.9 0.0 2.2 2 0 0 2 2 2 0 Lamin Tail Domain HSBP1 PF06825.12 ETO12114.1 - 0.14 12.0 4.1 8.7 6.3 0.8 2.7 1 1 1 2 2 2 0 Heat shock factor binding protein 1 Sugarporin_N PF11471.8 ETO12114.1 - 0.18 11.8 8.7 0.37 10.8 2.3 2.9 3 0 0 3 3 3 0 Maltoporin periplasmic N-terminal extension Spc24 PF08286.11 ETO12114.1 - 0.25 11.6 25.9 0.074 13.3 0.9 4.6 3 1 1 4 4 4 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.11 ETO12114.1 - 0.64 10.4 16.2 2.1 8.8 0.3 4.8 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) FliD_C PF07195.12 ETO12114.1 - 2.5 7.5 19.1 2.1 7.7 5.2 3.3 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 C-terminus HAD_2 PF13419.6 ETO12115.1 - 0.089 12.9 1.5 0.16 12.0 0.1 1.9 2 1 0 2 2 2 0 Haloacid dehalogenase-like hydrolase CDC45 PF02724.14 ETO12116.1 - 5.1 5.3 10.1 7.5 4.7 10.1 1.2 1 0 0 1 1 1 0 CDC45-like protein ABC1 PF03109.16 ETO12117.1 - 5.9e-17 61.9 0.0 6.6e-17 61.8 0.0 1.1 1 0 0 1 1 1 1 ABC1 family SsgA PF04686.12 ETO12117.1 - 0.12 12.4 0.0 0.19 11.8 0.0 1.3 1 1 0 1 1 1 0 Streptomyces sporulation and cell division protein, SsgA DUF3947 PF13135.6 ETO12118.1 - 5.5 7.3 11.5 10 6.4 11.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3947) L_protein_N PF15518.6 ETO12119.1 - 0.043 13.7 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 L protein N-terminus DUF562 PF04763.12 ETO12120.1 - 0.013 15.0 0.1 0.028 13.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF562) R3H PF01424.22 ETO12121.1 - 0.0004 20.3 0.0 0.0011 18.9 0.0 1.7 1 0 0 1 1 1 1 R3H domain Vps52 PF04129.12 ETO12123.1 - 3.9e-23 82.0 2.7 4.7e-23 81.7 2.7 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family NACHT PF05729.12 ETO12123.1 - 0.19 11.7 0.2 0.34 10.8 0.2 1.5 1 1 0 1 1 1 0 NACHT domain Beach PF02138.18 ETO12124.1 - 1.5e-27 96.7 0.1 1.5e-27 96.7 0.1 1.7 2 1 1 3 3 3 1 Beige/BEACH domain TPR_11 PF13414.6 ETO12124.1 - 1.7e-15 56.4 12.6 0.00049 19.7 0.2 4.4 4 0 0 4 4 4 4 TPR repeat TPR_1 PF00515.28 ETO12124.1 - 6.8e-12 44.7 15.1 0.0037 17.0 0.1 5.0 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12124.1 - 2.1e-10 40.2 15.2 0.0011 19.1 0.2 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12124.1 - 4.3e-10 38.9 16.2 0.024 14.7 0.7 5.5 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12124.1 - 1.8e-08 34.0 11.8 0.34 11.2 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12124.1 - 3e-08 33.8 0.1 6.6 7.8 0.0 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO12124.1 - 2.7e-06 27.8 5.0 0.4 11.2 0.8 5.0 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12124.1 - 1.7e-05 25.4 0.1 0.02 15.5 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat Cor1 PF04803.12 ETO12124.1 - 0.00057 20.1 1.0 0.0011 19.1 0.5 1.8 1 1 0 1 1 1 1 Cor1/Xlr/Xmr conserved region TPR_12 PF13424.6 ETO12124.1 - 0.0042 17.3 8.1 0.82 10.0 1.2 4.0 3 1 1 4 4 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO12124.1 - 0.18 11.9 2.8 14 5.9 0.1 3.5 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat DUF1048 PF06304.11 ETO12124.1 - 0.22 12.0 2.0 5.1 7.6 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1048) TGFb_propeptide PF00688.18 ETO12126.1 - 0.017 14.8 0.8 0.018 14.8 0.8 1.1 1 0 0 1 1 1 0 TGF-beta propeptide BAALC_N PF06989.12 ETO12126.1 - 0.14 12.5 0.4 0.14 12.5 0.4 2.0 2 0 0 2 2 2 0 BAALC N-terminus Alg6_Alg8 PF03155.15 ETO12126.1 - 0.58 9.1 0.9 0.72 8.7 0.9 1.0 1 0 0 1 1 1 0 ALG6, ALG8 glycosyltransferase family FANCI_S2 PF14676.6 ETO12127.1 - 0.008 16.5 3.7 1.6 9.0 0.1 2.3 2 0 0 2 2 2 2 FANCI solenoid 2 Catalase-rel PF06628.12 ETO12127.1 - 0.26 11.5 1.2 7.8 6.8 0.2 2.5 1 1 1 2 2 2 0 Catalase-related immune-responsive F-box-like PF12937.7 ETO12127.1 - 1 9.3 0.0 1 9.3 0.0 2.9 3 0 0 3 3 3 0 F-box-like Secretin_N_2 PF07655.13 ETO12129.1 - 2 9.0 33.2 0.59 10.7 9.5 4.0 3 0 0 3 3 3 0 Secretin N-terminal domain WD40 PF00400.32 ETO12130.1 - 6e-75 245.3 21.8 1.8e-10 41.2 0.7 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO12130.1 - 4.4e-21 75.2 0.3 0.017 14.1 0.0 7.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO12130.1 - 9.1e-21 74.0 7.7 0.0015 18.8 0.0 6.5 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO12130.1 - 6.8e-10 39.1 5.1 0.00025 21.0 0.0 4.4 3 1 1 5 5 5 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12130.1 - 3.6e-08 33.1 3.1 5.5 7.1 0.0 6.6 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO12130.1 - 7.1e-08 32.1 0.0 0.014 14.7 0.0 3.9 1 1 3 4 4 4 2 WD40-like domain DUF5570 PF17731.1 ETO12130.1 - 2e-05 24.7 2.1 17 5.5 0.0 5.7 1 1 5 6 6 6 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO12130.1 - 0.00037 19.4 7.4 0.11 11.2 1.8 4.1 1 1 2 3 3 3 2 Nup133 N terminal like Nup160 PF11715.8 ETO12130.1 - 0.00046 19.0 7.9 0.96 8.0 0.0 5.5 2 1 3 6 6 6 2 Nucleoporin Nup120/160 Gmad1 PF10647.9 ETO12130.1 - 0.00072 19.4 0.3 0.16 11.7 0.3 3.4 1 1 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain MMS1_N PF10433.9 ETO12130.1 - 0.0055 15.4 0.0 2.2 6.8 0.0 3.2 3 2 0 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term Me-amine-dh_H PF06433.11 ETO12130.1 - 0.011 14.7 0.0 1.3 7.8 0.0 2.7 3 0 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) NodS PF05401.11 ETO12130.1 - 0.012 15.2 0.2 1.3 8.6 0.0 3.4 2 1 0 3 3 3 0 Nodulation protein S (NodS) ACBP PF00887.19 ETO12131.1 - 7.8e-15 54.9 2.2 4.9e-10 39.5 1.6 2.5 2 1 0 2 2 2 2 Acyl CoA binding protein Gly-zipper_Omp PF13488.6 ETO12132.1 - 0.32 11.0 7.1 14 5.8 1.9 2.9 3 0 0 3 3 3 0 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO12132.1 - 0.52 10.1 7.3 15 5.4 7.3 2.4 1 1 0 1 1 1 0 YMGG-like Gly-zipper WD40 PF00400.32 ETO12133.1 - 5.5e-12 46.0 8.4 0.0029 18.4 0.0 6.1 6 1 1 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12133.1 - 0.00013 22.2 2.9 1.2 9.5 0.0 4.1 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO12133.1 - 0.2 11.6 5.6 20 5.3 0.1 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 ETO12134.1 - 4.1e-06 26.8 0.0 9.5e-06 25.6 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO12134.1 - 0.0025 18.1 0.0 0.0088 16.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO12134.1 - 0.089 13.3 0.7 1.3 9.6 0.1 3.1 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 ETO12134.1 - 0.099 13.0 0.1 0.69 10.3 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain Connexin PF00029.19 ETO12135.1 - 0.014 15.1 3.7 0.02 14.6 3.7 1.3 1 0 0 1 1 1 0 Connexin EOS1 PF12326.8 ETO12135.1 - 0.02 14.8 0.3 0.025 14.5 0.3 1.2 1 0 0 1 1 1 0 N-glycosylation protein zf-CSL PF05207.13 ETO12135.1 - 0.024 14.3 0.1 0.04 13.6 0.1 1.5 1 0 0 1 1 1 0 CSL zinc finger DUF2828 PF11443.8 ETO12135.1 - 0.23 9.5 7.2 0.24 9.4 7.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4569 PF15133.6 ETO12135.1 - 0.75 9.5 5.0 0.78 9.4 5.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Sec62 PF03839.16 ETO12135.1 - 4.6 6.7 14.4 6 6.3 14.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 HEAT PF02985.22 ETO12136.1 - 4.3e-05 23.4 0.6 0.1 12.9 0.0 2.9 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO12136.1 - 0.00046 20.5 0.0 0.0016 18.8 0.0 1.9 1 1 1 2 2 2 1 HEAT repeats RTP1_C1 PF10363.9 ETO12136.1 - 0.0027 17.9 3.2 0.0085 16.3 0.3 2.5 1 1 1 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETO12136.1 - 0.0033 17.5 8.4 0.012 15.7 6.2 2.0 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO12136.1 - 0.011 16.2 0.0 0.46 11.0 0.0 2.5 1 1 1 2 2 2 0 HEAT-like repeat RT_RNaseH_2 PF17919.1 ETO12136.1 - 0.028 14.4 0.4 9.6 6.3 0.1 2.6 2 1 0 2 2 2 0 RNase H-like domain found in reverse transcriptase Ribosomal_L22 PF00237.19 ETO12136.1 - 0.049 13.9 0.9 0.14 12.4 0.9 1.9 1 1 0 1 1 1 0 Ribosomal protein L22p/L17e DNA_pol3_gamma3 PF12169.8 ETO12136.1 - 0.098 12.6 0.1 1.5 8.7 0.0 2.5 1 1 1 3 3 3 0 DNA polymerase III subunits gamma and tau domain III DALR_1 PF05746.15 ETO12136.1 - 0.23 11.6 3.3 0.55 10.4 0.6 2.0 1 1 1 2 2 2 0 DALR anticodon binding domain Ank_2 PF12796.7 ETO12137.1 - 4.1e-06 27.3 0.2 2.8e-05 24.6 0.1 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO12137.1 - 0.00033 20.9 1.5 0.029 14.9 0.0 4.1 5 0 0 5 5 5 1 Ankyrin repeat Ank_5 PF13857.6 ETO12137.1 - 0.0041 17.4 0.6 0.052 13.9 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) RWP-RK PF02042.15 ETO12137.1 - 0.098 12.6 0.5 2 8.5 0.0 2.7 3 0 0 3 3 3 0 RWP-RK domain WD40 PF00400.32 ETO12138.1 - 1.1e-24 86.2 4.0 2.4e-11 44.0 0.4 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12138.1 - 1.6e-06 28.3 0.0 0.014 15.7 0.0 2.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12138.1 - 1.9e-05 23.8 0.1 0.074 12.0 0.1 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO12138.1 - 0.00011 21.1 0.5 0.026 13.3 0.1 2.1 1 1 1 2 2 2 2 Nup133 N terminal like PD40 PF07676.12 ETO12138.1 - 0.0064 16.4 0.6 1.7 8.7 0.0 3.1 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO12138.1 - 0.01 14.5 0.1 1.9 7.1 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO12138.1 - 0.034 12.7 0.0 0.042 12.4 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain CHAP PF05257.16 ETO12138.1 - 0.11 13.1 0.0 0.63 10.6 0.0 2.0 1 1 1 2 2 2 0 CHAP domain 3HCDH_N PF02737.18 ETO12139.1 - 2.9e-20 72.9 0.3 5.1e-13 49.3 0.0 2.3 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ETO12139.1 - 2.2e-18 66.6 0.1 9e-15 55.1 0.2 2.7 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain Ras PF00071.22 ETO12140.1 - 4.5e-19 68.6 0.0 6.4e-19 68.1 0.0 1.2 1 0 0 1 1 1 1 Ras family SIR4_SID PF16991.5 ETO12140.1 - 0.024 14.7 0.5 0.043 13.9 0.5 1.4 1 0 0 1 1 1 0 Sir4 SID domain Roc PF08477.13 ETO12140.1 - 0.05 13.8 0.0 0.11 12.7 0.0 1.6 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 ETO12141.1 - 1.2e-21 76.6 1.9 3.1e-11 43.6 0.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12141.1 - 7e-07 29.5 0.1 1.8e-05 25.0 0.0 2.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12141.1 - 1.1e-05 24.5 0.0 0.011 14.7 0.0 2.1 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO12141.1 - 0.0081 16.1 0.0 6 6.9 0.0 2.5 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO12141.1 - 0.016 14.5 0.0 0.02 14.2 0.0 1.1 1 0 0 1 1 1 0 WD40-like domain DUF727 PF05303.12 ETO12141.1 - 0.055 13.5 0.0 3.6 7.7 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF727) Gmad1 PF10647.9 ETO12141.1 - 0.11 12.3 0.0 8.2 6.1 0.0 2.4 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Xpo1 PF08389.12 ETO12144.1 - 2.8e-29 102.1 2.3 3.1e-29 101.9 1.2 1.6 2 0 0 2 2 2 1 Exportin 1-like protein RRM_1 PF00076.22 ETO12145.1 - 5.1e-05 23.0 0.1 0.00026 20.7 0.1 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4698 PF15769.5 ETO12147.1 - 0.012 14.7 2.7 0.016 14.3 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Glyco_hydro_63N PF16923.5 ETO12147.1 - 0.015 15.4 0.1 0.019 15.1 0.1 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 63 N-terminal domain DUF3586 PF12131.8 ETO12147.1 - 0.19 12.0 11.3 0.15 12.3 1.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3586) DUF443 PF04276.12 ETO12147.1 - 0.26 11.1 4.3 0.47 10.2 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF443) ETF_QO PF05187.13 ETO12148.1 - 3.4e-40 136.4 1.2 5.4e-40 135.7 0.1 1.9 1 1 1 2 2 2 1 Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S DAO PF01266.24 ETO12148.1 - 1.6e-10 41.2 0.2 2.4e-05 24.1 0.6 2.2 1 1 1 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETO12148.1 - 1.1e-08 34.6 1.0 7.9e-06 25.2 1.4 2.2 1 1 0 2 2 2 2 FAD binding domain Pyr_redox_2 PF07992.14 ETO12148.1 - 2.1e-06 27.2 0.2 4.3e-06 26.2 0.2 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO12148.1 - 2.2e-06 27.8 0.0 6.1e-06 26.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain NAD_binding_9 PF13454.6 ETO12148.1 - 4.8e-06 26.7 0.1 1.4e-05 25.1 0.1 2.0 1 1 0 1 1 1 1 FAD-NAD(P)-binding HI0933_like PF03486.14 ETO12148.1 - 1.2e-05 24.2 0.0 2.4e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 HI0933-like protein Thi4 PF01946.17 ETO12148.1 - 1.8e-05 24.1 0.0 1.8e-05 24.1 0.0 2.5 3 0 0 3 3 2 1 Thi4 family Lycopene_cycl PF05834.12 ETO12148.1 - 0.0002 20.6 0.3 0.0003 20.0 0.3 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 ETO12148.1 - 0.00041 19.7 0.1 0.00081 18.7 0.1 1.6 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ETO12148.1 - 0.00052 19.4 0.9 0.00096 18.5 0.9 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO12148.1 - 0.0006 20.3 0.1 0.16 12.5 0.3 2.4 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ETO12148.1 - 0.0022 17.4 0.0 0.0034 16.8 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Trp_halogenase PF04820.14 ETO12148.1 - 0.0026 16.7 1.5 0.0056 15.6 0.5 1.8 2 0 0 2 2 2 1 Tryptophan halogenase Fer4_7 PF12838.7 ETO12148.1 - 0.0071 16.9 3.7 0.011 16.2 0.9 2.3 2 0 0 2 2 2 1 4Fe-4S dicluster domain GIDA PF01134.22 ETO12148.1 - 0.051 12.7 0.0 0.093 11.8 0.0 1.4 1 0 0 1 1 1 0 Glucose inhibited division protein A Fer4_9 PF13187.6 ETO12148.1 - 0.089 13.0 2.6 0.36 11.0 0.5 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_21 PF14697.6 ETO12148.1 - 1 9.5 4.6 0.78 9.9 0.7 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain Fer4_2 PF12797.7 ETO12148.1 - 1.3 9.3 5.0 0.17 12.0 0.4 1.9 2 0 0 2 2 1 0 4Fe-4S binding domain Fer4_6 PF12837.7 ETO12148.1 - 1.9 8.7 4.8 0.51 10.5 0.7 2.1 2 0 0 2 2 2 0 4Fe-4S binding domain MFS_1 PF07690.16 ETO12149.1 - 0.0026 16.8 3.1 0.0041 16.1 1.8 1.7 1 1 1 2 2 2 1 Major Facilitator Superfamily DUF3382 PF11862.8 ETO12149.1 - 0.16 12.3 1.3 4 7.8 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF3382) Strabismus PF06638.11 ETO12149.1 - 0.94 8.0 6.1 1.7 7.2 6.1 1.4 1 0 0 1 1 1 0 Strabismus protein MGC-24 PF05283.11 ETO12150.1 - 4e-05 24.1 5.5 0.039 14.4 0.0 2.8 2 0 0 2 2 2 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin TFIIA PF03153.13 ETO12150.1 - 0.0014 18.8 31.1 0.0014 18.8 31.1 1.9 1 1 1 2 2 2 1 Transcription factor IIA, alpha/beta subunit SSP160 PF06933.11 ETO12150.1 - 0.02 13.1 6.0 0.035 12.3 6.0 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4713 PF15831.5 ETO12150.1 - 0.12 12.9 0.2 0.12 12.9 0.2 2.2 2 0 0 2 2 1 0 Domain of unknown function (DUF4713) DUF4746 PF15928.5 ETO12150.1 - 0.25 10.8 19.6 0.15 11.5 2.9 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4746) Prothymosin PF03247.14 ETO12150.1 - 0.46 11.0 58.1 0.34 11.4 21.7 3.4 3 0 0 3 3 3 0 Prothymosin/parathymosin family Methyltransf_12 PF08242.12 ETO12150.1 - 0.62 10.8 0.1 0.62 10.8 0.1 3.1 4 0 0 4 4 4 0 Methyltransferase domain Tim54 PF11711.8 ETO12150.1 - 1.7 7.3 20.4 0.8 8.4 6.3 3.2 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 DUF2208 PF09973.9 ETO12150.1 - 1.9 8.1 10.6 0.2 11.2 5.9 1.7 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) Myc_N PF01056.18 ETO12150.1 - 2.5 7.9 28.8 0.35 10.7 6.2 2.8 1 1 1 3 3 3 0 Myc amino-terminal region YL1 PF05764.13 ETO12150.1 - 2.8 8.0 33.3 0.57 10.3 10.0 2.5 2 0 0 2 2 2 0 YL1 nuclear protein Lipase_3 PF01764.25 ETO12151.1 - 1.5e-11 44.4 0.0 1.5e-09 37.8 0.0 2.6 2 0 0 2 2 2 2 Lipase (class 3) PepSY PF03413.19 ETO12152.1 - 0.44 11.2 2.2 1.5 9.4 2.2 1.9 1 1 0 1 1 1 0 Peptidase propeptide and YPEB domain TFB6 PF17110.5 ETO12153.1 - 0.095 12.4 2.3 0.1 12.3 2.3 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NOA36 PF06524.12 ETO12153.1 - 0.12 11.6 13.8 0.13 11.6 13.8 1.1 1 0 0 1 1 1 0 NOA36 protein Dynactin_p62 PF05502.13 ETO12153.1 - 0.57 8.9 2.7 0.66 8.7 2.7 1.0 1 0 0 1 1 1 0 Dynactin p62 family FAM176 PF14851.6 ETO12153.1 - 0.73 9.5 4.3 1 9.0 4.3 1.3 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 ETO12153.1 - 1.2 7.1 8.1 1.3 7.0 8.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 ETO12153.1 - 1.4 8.0 16.1 1.7 7.7 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2076 PF09849.9 ETO12153.1 - 2.6 8.0 14.2 2.7 8.0 14.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CENP-B_dimeris PF09026.10 ETO12153.1 - 4.9 7.6 15.8 8.9 6.8 15.8 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RRN3 PF05327.11 ETO12153.1 - 7.8 4.9 6.7 7.3 5.0 6.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Kelch_1 PF01344.25 ETO12155.1 - 7.3e-07 28.7 0.2 1.8e-05 24.2 0.3 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO12155.1 - 4.1e-05 23.7 1.2 0.082 13.2 0.6 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO12155.1 - 7.7e-05 22.6 0.6 0.0087 16.0 0.3 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO12155.1 - 0.00012 21.9 0.6 0.025 14.6 0.4 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO12155.1 - 0.00074 19.5 0.0 0.091 12.8 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO12155.1 - 0.00093 19.4 0.0 0.0098 16.2 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO12156.1 - 0.00011 21.7 2.0 0.00066 19.2 0.3 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO12156.1 - 0.0015 18.5 0.2 0.024 14.7 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO12156.1 - 0.004 17.1 2.4 0.21 11.6 0.4 3.6 3 1 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO12156.1 - 0.0098 16.2 3.0 0.52 10.7 0.0 3.4 2 1 1 3 3 3 1 Kelch motif Peptidase_C14 PF00656.22 ETO12158.1 - 8.6e-12 45.5 1.2 8.6e-12 45.5 1.2 1.7 2 0 0 2 2 2 1 Caspase domain DUF4363 PF14276.6 ETO12158.1 - 0.01 15.9 13.1 0.016 15.4 7.5 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4363) DUF719 PF05334.13 ETO12158.1 - 0.037 14.2 0.0 0.15 12.2 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF719) TH1 PF04858.13 ETO12163.1 - 3.6e-08 32.5 1.0 4.8e-08 32.1 1.0 1.1 1 0 0 1 1 1 1 TH1 protein DUF4804 PF16062.5 ETO12165.1 - 1.3e-85 288.0 8.5 4.4e-41 141.2 2.2 4.1 1 1 2 3 3 3 3 Domain of unknown function (DUF4804) Pam16 PF03656.13 ETO12165.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.1 2 0 0 2 2 2 0 Pam16 Pex14_N PF04695.13 ETO12165.1 - 0.87 10.2 5.9 0.59 10.8 1.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region WD40 PF00400.32 ETO12166.1 - 8.1e-10 39.1 0.2 0.043 14.7 0.1 3.2 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12166.1 - 0.00012 22.3 0.0 0.0069 16.7 0.0 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 ETO12166.1 - 0.065 13.2 0.0 1.7 8.7 0.0 2.4 2 0 0 2 2 2 0 PQQ enzyme repeat DUF1687 PF07955.11 ETO12168.1 - 0.035 14.6 0.4 0.2 12.1 0.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1687) GATase PF00117.28 ETO12169.1 - 0.00012 21.9 0.0 0.00014 21.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO12169.1 - 0.0023 17.7 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 Peptidase C26 Imm12 PF15560.6 ETO12169.1 - 0.078 12.9 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 12 NACHT PF05729.12 ETO12170.1 - 6.4e-10 39.2 0.0 1.4e-09 38.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO12170.1 - 0.0002 21.9 0.0 0.0021 18.6 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO12170.1 - 0.0027 18.0 0.1 0.012 15.9 0.0 2.2 2 1 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETO12170.1 - 0.019 14.9 0.0 0.052 13.5 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 ETO12170.1 - 0.053 13.9 1.8 0.39 11.1 0.1 3.1 2 2 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO12170.1 - 0.056 14.0 0.0 0.2 12.1 0.0 2.0 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 ETO12170.1 - 0.061 12.7 0.7 0.41 10.0 0.0 2.4 2 1 0 2 2 2 0 KaiC TniB PF05621.11 ETO12170.1 - 0.065 12.6 0.0 0.15 11.5 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein DAP3 PF10236.9 ETO12170.1 - 0.34 10.0 6.0 0.92 8.6 0.1 3.1 4 0 0 4 4 4 0 Mitochondrial ribosomal death-associated protein 3 IES5 PF17335.2 ETO12170.1 - 1.1 9.6 4.9 0.58 10.4 0.5 2.7 2 1 0 2 2 2 0 Ino80 complex subunit 5 Ogr_Delta PF04606.12 ETO12171.1 - 0.12 12.3 0.4 0.43 10.6 0.4 2.0 1 1 0 1 1 1 0 Ogr/Delta-like zinc finger zf-Mss51 PF13824.6 ETO12171.1 - 0.22 11.7 1.5 0.47 10.6 0.3 2.0 1 1 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 zf-H2C2_2 PF13465.6 ETO12171.1 - 0.27 11.7 1.4 0.33 11.5 0.1 1.8 2 0 0 2 2 2 0 Zinc-finger double domain DNA_ligase_ZBD PF03119.16 ETO12171.1 - 0.33 11.0 1.5 2.4 8.2 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain Kelch_1 PF01344.25 ETO12174.1 - 1.1e-05 24.9 1.5 0.00071 19.1 0.0 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO12174.1 - 1.3e-05 25.3 0.7 0.011 16.1 0.0 3.5 2 1 1 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO12174.1 - 0.0068 16.7 0.0 0.024 14.9 0.0 2.0 1 0 0 1 1 1 1 Galactose oxidase, central domain PAP1 PF08601.10 ETO12174.1 - 3.4 7.3 20.5 1.7 8.3 13.8 2.1 1 1 0 2 2 2 0 Transcription factor PAP1 Menin PF05053.13 ETO12174.1 - 7.4 4.8 10.6 14 3.9 10.6 1.3 1 0 0 1 1 1 0 Menin FXMR_C2 PF16098.5 ETO12176.1 - 0.025 15.1 1.3 0.062 13.8 1.3 1.7 1 1 0 1 1 1 0 Fragile X-related mental retardation protein C-terminal region 2 DUF2052 PF09747.9 ETO12177.1 - 0.00039 20.6 3.3 0.00039 20.6 3.3 1.9 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) FAM176 PF14851.6 ETO12177.1 - 0.0075 15.9 2.8 0.02 14.5 2.8 1.7 1 0 0 1 1 1 1 FAM176 family MscS_TM PF12794.7 ETO12177.1 - 0.023 13.6 0.4 0.05 12.5 0.4 1.6 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF5523 PF17661.1 ETO12177.1 - 0.08 12.6 12.7 0.16 11.6 7.9 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5523) RNase_H2_suC PF08615.11 ETO12177.1 - 0.19 11.9 1.9 1.1 9.4 0.3 2.7 3 0 0 3 3 3 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Presenilin PF01080.17 ETO12177.1 - 0.33 9.7 4.0 0.17 10.6 0.5 2.0 2 0 0 2 2 2 0 Presenilin DDHD PF02862.17 ETO12177.1 - 1.4 9.0 5.2 0.49 10.5 0.7 2.4 3 0 0 3 3 3 0 DDHD domain RXT2_N PF08595.11 ETO12177.1 - 2.7 8.0 14.3 0.22 11.6 6.5 2.6 2 0 0 2 2 2 0 RXT2-like, N-terminal Gti1_Pac2 PF09729.9 ETO12177.1 - 4.1 7.5 7.7 1.1 9.4 1.3 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family MRNIP PF15749.5 ETO12177.1 - 5 7.9 13.6 0.65 10.7 4.7 2.9 2 0 0 2 2 2 0 MRN-interacting protein PcfK PF14058.6 ETO12177.1 - 5.2 7.4 16.6 19 5.5 11.2 2.8 2 0 0 2 2 2 0 PcfK-like protein TFB6 PF17110.5 ETO12177.1 - 6.6 6.4 6.9 18 5.0 6.9 1.7 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CPSF100_C PF13299.6 ETO12177.1 - 8.7 6.5 9.3 0.43 10.8 3.0 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 ETO12179.1 - 0.004 15.2 1.3 0.0049 14.9 1.3 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Med19 PF10278.9 ETO12179.1 - 0.02 14.9 3.2 0.02 14.9 3.2 1.8 1 1 1 2 2 2 0 Mediator of RNA pol II transcription subunit 19 DUF3464 PF11947.8 ETO12179.1 - 0.022 14.5 1.7 0.036 13.8 0.4 1.9 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Med30 PF11315.8 ETO12180.1 - 0.0054 16.9 1.0 0.011 16.0 1.0 1.5 1 0 0 1 1 1 1 Mediator complex subunit 30 DUF3198 PF11433.8 ETO12180.1 - 0.016 15.1 0.1 0.039 13.8 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3198) Sprouty PF05210.13 ETO12181.1 - 0.077 13.4 0.1 0.18 12.2 0.0 1.6 2 0 0 2 2 2 0 Sprouty protein (Spry) DUF1700 PF08006.11 ETO12182.1 - 0.2 11.2 2.6 0.24 10.9 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1700) ELMO_CED12 PF04727.13 ETO12183.1 - 1e-24 87.6 7.3 4.1e-24 85.6 7.3 1.9 1 1 0 1 1 1 1 ELMO/CED-12 family Eno-Rase_FAD_bd PF07055.12 ETO12183.1 - 0.01 16.2 0.0 0.04 14.3 0.0 2.0 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain Trypsin_2 PF13365.6 ETO12184.1 - 6.6e-11 43.3 0.0 1.3e-10 42.3 0.0 1.5 1 0 0 1 1 1 1 Trypsin-like peptidase domain PDZ_2 PF13180.6 ETO12184.1 - 7.8e-07 29.3 0.1 2.2e-06 27.9 0.1 1.8 1 1 0 1 1 1 1 PDZ domain Codanin-1_C PF15296.6 ETO12184.1 - 0.0075 16.3 2.3 0.04 14.0 2.7 1.9 2 0 0 2 2 2 1 Codanin-1 C-terminus Trypsin PF00089.26 ETO12184.1 - 0.015 15.2 0.8 0.024 14.5 0.0 1.7 2 0 0 2 2 2 0 Trypsin Peptidase_S29 PF02907.15 ETO12184.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Hepatitis C virus NS3 protease PDZ PF00595.24 ETO12184.1 - 0.14 12.6 0.0 0.36 11.2 0.0 1.7 1 0 0 1 1 1 0 PDZ domain Peptidase_S55 PF05580.12 ETO12184.1 - 0.24 11.3 0.1 0.24 11.3 0.1 1.9 2 0 0 2 2 2 0 SpoIVB peptidase S55 Aminotran_1_2 PF00155.21 ETO12185.1 - 7.8e-34 117.4 0.1 9.7e-34 117.1 0.1 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ETO12185.1 - 1.1e-05 24.5 0.0 1.4e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Cys_Met_Meta_PP PF01053.20 ETO12185.1 - 0.0012 17.5 0.0 0.0017 16.9 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme ATPase-cat_bd PF12156.8 ETO12185.1 - 0.028 15.1 0.7 0.13 13.1 0.1 2.3 2 1 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase Aminotran_MocR PF12897.7 ETO12185.1 - 0.036 12.9 0.0 0.045 12.5 0.0 1.1 1 0 0 1 1 1 0 Alanine-glyoxylate amino-transferase SpuA_C PF18033.1 ETO12185.1 - 0.081 13.0 0.1 0.17 12.0 0.1 1.5 1 0 0 1 1 1 0 SpuA C-terminal Med27 PF11571.8 ETO12186.1 - 4.2e-06 27.0 0.8 2.2e-05 24.7 0.3 2.6 1 1 1 2 2 2 1 Mediator complex subunit 27 MHCassoc_trimer PF08831.10 ETO12186.1 - 0.51 10.4 3.5 7.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Class II MHC-associated invariant chain trimerisation domain RGS PF00615.19 ETO12188.1 - 1.1e-10 41.8 0.9 2.9e-10 40.4 0.9 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain E7 PF00527.18 ETO12188.1 - 0.55 10.5 9.7 6.7 7.0 5.9 2.7 2 0 0 2 2 2 0 E7 protein, Early protein hSac2 PF12456.8 ETO12189.1 - 0.02 14.6 0.1 0.046 13.4 0.1 1.6 1 0 0 1 1 1 0 Inositol phosphatase Ion_trans PF00520.31 ETO12189.1 - 0.96 8.6 6.0 0.17 11.1 0.3 2.5 3 0 0 3 3 3 0 Ion transport protein PA PF02225.22 ETO12190.1 - 0.004 17.1 0.0 0.0058 16.6 0.0 1.3 1 0 0 1 1 1 1 PA domain YajC PF02699.15 ETO12190.1 - 0.18 11.7 0.7 0.3 11.0 0.7 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Thr_synth_N PF14821.6 ETO12191.1 - 1.7e-23 82.6 0.0 3.2e-23 81.7 0.0 1.4 1 0 0 1 1 1 1 Threonine synthase N terminus DUF2465 PF10239.9 ETO12192.1 - 2.9e-32 112.2 0.0 2.5e-26 92.7 0.0 2.3 2 1 0 2 2 2 2 Protein of unknown function (DUF2465) DUF1631 PF07793.11 ETO12192.1 - 0.37 9.1 9.9 0.62 8.4 9.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Trypan_PARP PF05887.11 ETO12192.1 - 7.1 6.6 22.0 8.2 6.4 20.8 1.7 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) IBR PF01485.21 ETO12193.1 - 2.3e-09 37.4 15.3 0.00013 22.1 3.1 2.3 2 0 0 2 2 2 2 IBR domain, a half RING-finger domain DUF839 PF05787.13 ETO12193.1 - 0.032 13.4 0.6 0.048 12.8 0.6 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) zf-ribbon_3 PF13248.6 ETO12193.1 - 4.2 6.9 9.2 6.5 6.3 0.0 3.5 3 1 1 4 4 3 0 zinc-ribbon domain zinc_ribbon_2 PF13240.6 ETO12193.1 - 5.4 6.9 9.1 19 5.1 0.2 3.4 3 0 0 3 3 3 0 zinc-ribbon domain Transcrip_act PF04949.13 ETO12194.1 - 0.00037 20.4 13.7 0.00037 20.4 13.7 2.2 2 1 1 3 3 3 1 Transcriptional activator PPR_2 PF13041.6 ETO12195.1 - 0.00078 19.6 1.6 0.008 16.4 0.3 3.2 3 1 0 3 3 3 1 PPR repeat family PPR PF01535.20 ETO12195.1 - 0.0017 18.4 2.3 1.7 9.1 0.0 4.3 4 0 0 4 4 4 1 PPR repeat PPR_3 PF13812.6 ETO12195.1 - 0.0027 17.7 0.3 2.1 8.5 0.0 4.4 4 1 1 5 5 5 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO12195.1 - 0.0083 15.8 1.8 3.4 7.5 0.0 3.0 3 0 0 3 3 3 2 PPR repeat Ras PF00071.22 ETO12196.1 - 8.4e-16 58.0 0.0 4.7e-14 52.3 0.0 2.9 1 1 0 1 1 1 1 Ras family gag-asp_proteas PF13975.6 ETO12199.1 - 0.00042 20.8 0.0 0.0009 19.8 0.0 1.6 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease zf-CCHC PF00098.23 ETO12199.1 - 0.00084 19.3 3.2 0.00084 19.3 3.2 1.8 2 0 0 2 2 2 1 Zinc knuckle RVP PF00077.20 ETO12199.1 - 0.001 19.3 0.0 0.0026 18.1 0.0 1.7 1 0 0 1 1 1 1 Retroviral aspartyl protease TPR_12 PF13424.6 ETO12200.1 - 1.3e-73 243.3 8.4 2.6e-17 62.9 0.3 7.9 3 3 6 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12200.1 - 3.6e-59 194.3 56.7 1e-07 31.4 1.7 10.9 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12200.1 - 5.1e-51 169.2 3.0 5.5e-07 29.3 0.0 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12200.1 - 1.6e-47 155.8 33.8 1.7e-06 27.7 0.4 10.0 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12200.1 - 3.1e-36 120.7 11.0 6.2e-05 22.7 0.0 9.9 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12200.1 - 4.7e-36 120.0 50.8 9.2e-06 25.5 0.3 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_11 PF13414.6 ETO12200.1 - 8.7e-21 73.3 50.5 7.3e-05 22.4 0.5 11.8 9 5 4 13 13 12 8 TPR repeat TPR_6 PF13174.6 ETO12200.1 - 6.8e-16 57.8 8.4 0.046 14.4 0.0 9.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12200.1 - 4.8e-14 51.7 26.4 0.19 12.2 0.2 10.0 8 3 1 9 9 9 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12200.1 - 6.8e-14 52.2 0.0 0.046 14.4 0.0 7.3 7 2 1 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12200.1 - 1.9e-11 43.8 0.0 6.6 7.8 0.0 7.8 7 1 1 8 8 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO12200.1 - 6.3e-07 29.1 0.0 0.0003 20.3 0.0 2.7 2 1 1 3 3 3 1 MalT-like TPR region DUF2225 PF09986.9 ETO12200.1 - 1.1e-06 28.5 21.4 0.0038 17.0 0.8 4.5 1 1 4 5 5 5 3 Uncharacterized protein conserved in bacteria (DUF2225) ANAPC3 PF12895.7 ETO12200.1 - 1.6e-06 28.3 21.2 0.097 12.9 0.3 6.5 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO12200.1 - 5.3e-06 25.8 2.2 0.12 11.9 0.0 5.0 5 0 0 5 5 5 2 SHNi-TPR TPR_3 PF07720.12 ETO12200.1 - 2e-05 24.5 22.3 0.3 11.1 0.1 6.8 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO12200.1 - 0.00019 21.9 0.6 1.4 9.5 0.0 4.8 4 1 1 5 5 5 1 Tetratricopeptide repeat DUF627 PF04781.12 ETO12200.1 - 0.00049 20.1 7.6 4.1 7.5 0.2 5.1 4 1 1 5 5 4 2 Protein of unknown function (DUF627) RPN7 PF10602.9 ETO12200.1 - 0.0005 19.8 16.4 0.31 10.7 0.5 5.8 2 2 3 5 5 5 2 26S proteasome subunit RPN7 MIT PF04212.18 ETO12200.1 - 0.0021 18.1 23.8 1.5 8.9 0.2 7.4 8 0 0 8 8 8 1 MIT (microtubule interacting and transport) domain TPR_9 PF13371.6 ETO12200.1 - 0.013 15.7 0.0 13 6.0 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat NRBF2_MIT PF17169.4 ETO12200.1 - 0.17 12.1 5.3 16 5.8 0.0 5.4 5 2 2 7 7 7 0 MIT domain of nuclear receptor-binding factor 2 PPR PF01535.20 ETO12200.1 - 0.2 12.0 11.4 4 7.9 0.1 5.6 7 0 0 7 7 5 0 PPR repeat SPO22 PF08631.10 ETO12200.1 - 0.23 10.9 11.9 1.1 8.7 0.3 4.5 2 2 2 4 4 4 0 Meiosis protein SPO22/ZIP4 like Prefoldin PF02996.17 ETO12200.1 - 1.2 9.0 12.9 21 5.1 0.0 6.0 5 2 2 7 7 7 0 Prefoldin subunit T3SchapCesA PF11439.8 ETO12200.1 - 1.7 8.8 5.3 1.1 9.4 0.2 3.3 4 0 0 4 4 4 0 Type III secretion system filament chaperone CesA Peptidase_C14 PF00656.22 ETO12201.1 - 6.6e-14 52.5 1.1 1.3e-13 51.5 0.3 1.8 2 1 0 2 2 2 1 Caspase domain ATP_transf PF09830.9 ETO12202.1 - 1.5e-07 31.5 0.0 2.7e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 ATP adenylyltransferase HIT PF01230.23 ETO12202.1 - 0.0019 18.9 0.1 0.0066 17.2 0.0 1.9 1 1 0 1 1 1 1 HIT domain zf-H2C2_5 PF13909.6 ETO12203.1 - 0.00071 19.3 0.3 0.0017 18.1 0.3 1.7 1 0 0 1 1 1 1 C2H2-type zinc-finger domain zf-C2H2 PF00096.26 ETO12203.1 - 0.0061 16.9 0.3 0.013 15.9 0.3 1.6 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO12203.1 - 0.39 11.2 2.9 2.4 8.7 0.2 2.4 2 0 0 2 2 2 0 Zinc-finger double domain DASH_Spc19 PF08287.11 ETO12204.1 - 0.0063 16.4 1.9 0.0071 16.3 1.9 1.1 1 0 0 1 1 1 1 Spc19 pRN1_helical PF13010.6 ETO12204.1 - 0.022 14.7 1.5 0.023 14.6 1.5 1.1 1 0 0 1 1 1 0 Primase helical domain CLZ PF16526.5 ETO12204.1 - 0.031 14.6 3.7 0.036 14.4 3.7 1.1 1 0 0 1 1 1 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF948 PF06103.11 ETO12204.1 - 0.1 12.9 1.0 0.2 11.9 1.0 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DnaB_C PF03796.15 ETO12205.1 - 0.12 11.7 1.5 0.18 11.1 1.2 1.5 1 1 1 2 2 2 0 DnaB-like helicase C terminal domain 2OG-FeII_Oxy_3 PF13640.6 ETO12206.1 - 0.00032 21.5 0.0 0.0012 19.7 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Hist_rich_Ca-bd PF10529.9 ETO12206.1 - 0.075 13.3 2.6 0.2 11.9 2.6 1.7 1 0 0 1 1 1 0 Histidine-rich Calcium-binding repeat region WD40 PF00400.32 ETO12211.1 - 5.2e-20 71.4 12.4 3.2e-07 30.9 1.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12211.1 - 4.1e-06 27.0 0.0 0.11 12.9 0.0 2.5 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12211.1 - 5.7e-06 25.3 0.8 0.0017 17.1 0.5 2.4 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12211.1 - 0.0023 17.3 0.7 1.3 8.3 0.1 2.6 1 1 2 3 3 3 2 WD40-like domain WD40 PF00400.32 ETO12212.1 - 6.8e-64 210.3 16.4 9.7e-10 38.9 0.0 7.3 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12212.1 - 5.7e-19 68.2 3.7 0.0025 18.1 0.0 5.8 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12212.1 - 4.4e-13 48.9 0.2 0.18 10.8 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO12212.1 - 2e-10 40.9 0.3 0.0016 18.4 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO12212.1 - 2.1e-08 33.1 2.2 9.2e-05 21.1 0.0 3.8 1 1 2 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO12212.1 - 2.5e-08 33.6 1.2 4.9 7.2 0.0 6.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO12212.1 - 3e-07 30.1 1.4 0.089 12.1 0.0 4.3 2 2 3 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO12212.1 - 4.1e-07 29.0 4.0 0.3 9.7 0.0 5.2 2 1 2 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO12212.1 - 9.5e-06 24.6 2.2 3.4 6.3 0.0 4.2 2 1 2 4 4 4 3 Nup133 N terminal like DUF5570 PF17731.1 ETO12212.1 - 0.0031 17.6 1.9 11 6.1 0.0 4.0 4 1 1 5 5 5 1 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO12212.1 - 0.005 15.9 0.0 1.3 8.0 0.0 2.2 1 1 1 2 2 2 2 Coatomer WD associated region Proteasome_A_N PF10584.9 ETO12212.1 - 0.0051 16.5 6.4 3.3 7.5 0.0 5.2 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature VID27 PF08553.10 ETO12212.1 - 0.0084 15.2 0.0 13 4.8 0.0 3.4 2 1 2 4 4 4 0 VID27 C-terminal WD40-like domain DPPIV_N PF00930.21 ETO12212.1 - 0.012 14.4 0.3 8.5 5.0 0.0 3.7 2 2 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF4265 PF14085.6 ETO12212.1 - 0.041 13.9 0.1 6.3 6.8 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4265) E1_UFD PF09358.10 ETO12214.1 - 0.068 13.9 0.1 0.091 13.5 0.1 1.3 1 1 0 1 1 1 0 Ubiquitin fold domain Glucokinase PF02685.16 ETO12214.1 - 0.11 11.4 0.1 0.15 11.1 0.1 1.1 1 0 0 1 1 1 0 Glucokinase Inositol_P PF00459.25 ETO12216.1 - 2.8e-41 141.8 0.0 6e-32 111.2 0.0 2.1 2 0 0 2 2 2 2 Inositol monophosphatase family Lustrin_cystein PF14625.6 ETO12217.1 - 0.068 13.6 0.4 0.12 12.8 0.4 1.4 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain TPMT PF05724.11 ETO12220.1 - 7.3e-10 38.9 0.0 9e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 Thiopurine S-methyltransferase (TPMT) ECH_2 PF16113.5 ETO12221.1 - 9e-112 373.9 0.0 1.1e-111 373.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ETO12221.1 - 3e-27 95.5 0.3 7.4e-25 87.7 0.0 2.6 1 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase IL12 PF03039.14 ETO12221.1 - 0.0077 15.6 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 Interleukin-12 alpha subunit HTH_9 PF08221.11 ETO12221.1 - 0.082 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 helix-turn-helix domain DUF1512 PF07431.12 ETO12221.1 - 0.17 10.9 0.2 0.34 9.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1512) WD40 PF00400.32 ETO12222.1 - 3.2e-65 214.5 21.9 4.6e-10 39.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12222.1 - 4.7e-22 78.1 4.6 0.0024 18.1 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12222.1 - 1.2e-16 60.6 0.1 0.021 13.8 0.0 6.9 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12222.1 - 3.3e-13 49.6 1.2 0.00014 21.3 0.0 3.7 1 1 3 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO12222.1 - 6.5e-08 31.5 0.5 0.0038 15.8 0.0 3.0 1 1 1 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO12222.1 - 2.4e-06 26.5 5.0 0.77 8.3 0.0 5.5 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PQQ PF01011.21 ETO12222.1 - 0.001 18.9 0.3 7 6.8 0.0 4.1 5 0 0 5 5 5 2 PQQ enzyme repeat Utp8 PF10395.9 ETO12222.1 - 0.0029 16.2 0.8 0.24 9.8 0.1 3.2 1 1 2 3 3 3 1 Utp8 family DUF5570 PF17731.1 ETO12222.1 - 0.03 14.4 0.2 5.2 7.2 0.0 3.6 1 1 4 5 5 5 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO12222.1 - 0.034 12.9 11.1 1.6 7.4 0.4 4.6 1 1 5 6 6 6 0 Nup133 N terminal like HARP PF07443.13 ETO12222.1 - 0.063 12.9 0.1 8.8 6.1 0.0 3.8 4 0 0 4 4 4 0 HepA-related protein (HARP) PD40 PF07676.12 ETO12222.1 - 4.6 7.3 14.3 77 3.4 0.0 6.1 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO12223.1 - 7.5e-20 70.9 16.6 1.3e-07 32.1 1.9 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12223.1 - 3.7e-06 27.1 0.4 0.03 14.6 0.1 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12223.1 - 6.5e-06 25.1 2.3 0.005 15.5 0.4 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12223.1 - 0.0033 16.8 1.1 0.0033 16.8 1.1 2.7 2 1 1 3 3 3 1 WD40-like domain Kelch_2 PF07646.15 ETO12226.1 - 0.091 12.8 0.9 2.2 8.4 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO12226.1 - 0.13 12.6 1.2 7.6 7.0 0.0 3.0 2 1 1 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO12226.1 - 0.37 10.4 1.7 21 4.8 0.1 3.3 4 0 0 4 4 4 0 Kelch motif LPD25 PF18840.1 ETO12227.1 - 0.05 14.1 0.4 0.11 13.1 0.4 1.6 1 0 0 1 1 1 0 Large polyvalent protein associated domain 25 LCM PF04072.14 ETO12229.1 - 2.7e-36 125.3 0.0 6e-36 124.2 0.0 1.6 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Spc7 PF08317.11 ETO12229.1 - 0.015 14.2 5.2 0.024 13.5 5.2 1.3 1 0 0 1 1 1 0 Spc7 kinetochore protein TFIIS_M PF07500.14 ETO12229.1 - 0.5 10.9 7.1 1.1 9.8 7.1 1.6 1 0 0 1 1 1 0 Transcription factor S-II (TFIIS), central domain DUF4312 PF14189.6 ETO12229.1 - 0.53 10.3 4.1 11 6.1 0.1 3.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4312) ART PF01129.18 ETO12230.1 - 8.7e-05 21.9 0.1 0.00016 21.0 0.1 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase Kelch_6 PF13964.6 ETO12233.1 - 2.3e-07 30.8 2.1 0.03 14.6 0.1 3.6 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ETO12233.1 - 8.2e-07 28.8 1.7 0.0053 16.7 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO12233.1 - 2.2e-05 24.0 0.1 0.094 12.3 0.0 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO12233.1 - 6.5e-05 22.8 1.5 0.0047 16.9 0.2 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO12233.1 - 0.00032 20.7 0.1 0.45 10.6 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain NHase_alpha PF02979.16 ETO12233.1 - 0.071 12.4 0.1 0.76 9.1 0.0 2.0 2 0 0 2 2 2 0 Nitrile hydratase, alpha chain WD40 PF00400.32 ETO12234.1 - 2e-20 72.7 6.2 3.7e-05 24.4 0.1 4.8 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12234.1 - 3.1e-06 27.4 0.1 0.0023 18.2 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12234.1 - 0.00026 19.8 0.3 0.12 11.0 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF1541 PF07563.11 ETO12234.1 - 0.039 13.8 0.0 11 6.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) WD40 PF00400.32 ETO12235.1 - 1e-06 29.4 0.8 8.1e-06 26.5 0.1 2.7 2 2 0 2 2 2 1 WD domain, G-beta repeat Kelch_6 PF13964.6 ETO12236.1 - 0.039 14.3 0.5 2 8.8 0.0 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO12236.1 - 0.058 13.0 0.2 1.7 8.3 0.0 2.7 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETO12236.1 - 0.2 11.7 1.1 33 4.6 0.0 3.4 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO12237.1 - 6.6e-37 124.9 25.1 7.7e-07 29.7 1.1 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12237.1 - 4.9e-11 42.8 2.5 0.23 11.8 0.0 5.9 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12237.1 - 9.5e-10 37.7 6.1 0.043 12.5 0.4 4.6 3 2 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12237.1 - 4.1e-05 23.1 13.2 0.019 14.3 2.5 5.2 3 2 1 5 5 5 2 WD40-like domain eIF2A PF08662.11 ETO12237.1 - 0.00026 20.9 7.1 0.7 9.7 2.0 4.6 1 1 4 5 5 5 2 Eukaryotic translation initiation factor eIF2A Kelch_6 PF13964.6 ETO12237.1 - 0.63 10.4 11.3 24 5.4 0.5 5.7 4 1 1 5 5 5 0 Kelch motif WD40 PF00400.32 ETO12238.1 - 4.3e-38 128.6 16.4 4.6e-07 30.4 1.1 7.9 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12238.1 - 9.1e-12 45.1 2.1 0.013 15.8 0.0 4.8 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12238.1 - 2.8e-07 29.6 7.7 0.017 13.8 0.2 5.2 1 1 5 6 6 6 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO12238.1 - 3.3e-06 27.1 2.8 0.023 14.7 0.3 3.7 3 1 1 4 4 4 2 Ciliary BBSome complex subunit 2, middle region HARP PF07443.13 ETO12238.1 - 0.0027 17.3 2.4 15 5.3 0.0 4.2 5 0 0 5 5 5 2 HepA-related protein (HARP) Thioredoxin_13 PF18401.1 ETO12239.1 - 0.04 13.8 0.5 0.065 13.1 0.1 1.7 2 0 0 2 2 2 0 Thioredoxin-like domain Patched PF02460.18 ETO12239.1 - 0.059 11.4 1.1 0.076 11.1 1.1 1.1 1 0 0 1 1 1 0 Patched family DUF1778 PF08681.11 ETO12239.1 - 0.089 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1778) Scs3p PF10261.9 ETO12240.1 - 0.033 13.7 0.8 0.057 12.9 0.7 1.3 1 1 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Cmyb_C PF09316.10 ETO12240.1 - 0.041 13.5 0.5 0.041 13.5 0.5 1.7 2 0 0 2 2 2 0 C-myb, C-terminal Nitro_FeMo-Co PF02579.17 ETO12240.1 - 0.15 12.4 0.2 4.5 7.7 0.0 2.3 2 0 0 2 2 2 0 Dinitrogenase iron-molybdenum cofactor Tom7 PF08038.12 ETO12241.1 - 0.00028 20.5 0.2 0.00046 19.8 0.2 1.3 1 0 0 1 1 1 1 TOM7 family DUF4710 PF15828.5 ETO12241.1 - 0.78 9.9 4.5 5.1 7.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Pur_ac_phosph_N PF16656.5 ETO12242.1 - 0.0034 17.9 0.2 0.014 15.9 0.2 2.2 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 ETO12242.1 - 0.056 13.8 0.0 0.35 11.2 0.0 2.4 2 0 0 2 2 2 0 Fibronectin type III domain Nop14 PF04147.12 ETO12242.1 - 0.11 10.7 41.0 0.15 10.2 41.0 1.1 1 0 0 1 1 1 0 Nop14-like family Proteasome PF00227.26 ETO12243.1 - 1.3e-48 165.0 0.9 1.7e-48 164.7 0.9 1.1 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 ETO12243.1 - 0.029 13.8 1.1 0.1 12.0 0.0 2.3 2 0 0 2 2 2 0 Proteasome beta subunits C terminal MerB PF03243.15 ETO12245.1 - 4.8e-09 36.4 0.0 6.5e-09 36.0 0.0 1.2 1 0 0 1 1 1 1 Alkylmercury lyase DUF2604 PF10790.9 ETO12246.1 - 0.0015 18.8 0.1 0.0029 17.8 0.1 1.4 1 0 0 1 1 1 1 Protein of Unknown function (DUF2604) Serinc PF03348.15 ETO12247.1 - 1.5e-07 30.7 8.8 0.00042 19.4 0.5 2.1 1 1 1 2 2 2 2 Serine incorporator (Serinc) A2L_zn_ribbon PF08792.10 ETO12247.1 - 0.016 14.9 1.8 0.18 11.6 0.0 2.4 2 0 0 2 2 2 0 A2L zinc ribbon domain HIGH_NTase1_ass PF16581.5 ETO12248.1 - 0.075 13.0 0.1 0.16 12.0 0.1 1.6 1 0 0 1 1 1 0 Cytidyltransferase-related C-terminal region DpnI_C PF17726.1 ETO12248.1 - 0.2 11.8 4.2 0.12 12.5 0.5 2.5 2 1 0 2 2 2 0 Dam-replacing HTH domain MCPVI PF02993.14 ETO12248.1 - 0.33 10.7 2.1 0.3 10.9 0.2 1.8 2 0 0 2 2 2 0 Minor capsid protein VI TrkA_C PF02080.21 ETO12251.1 - 3.1e-10 39.7 0.0 1.3e-09 37.8 0.0 1.9 2 0 0 2 2 2 1 TrkA-C domain Pex2_Pex12 PF04757.14 ETO12251.1 - 1.3 8.6 6.4 1.1 8.8 0.9 2.4 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region Secretin_N_2 PF07655.13 ETO12251.1 - 8.1 7.1 33.1 18 6.0 10.1 2.8 2 0 0 2 2 2 0 Secretin N-terminal domain DUF5520 PF17658.1 ETO12254.1 - 0.0019 17.4 0.1 0.0019 17.4 0.1 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5520) WD40 PF00400.32 ETO12255.1 - 2.4e-43 145.2 29.2 3.2e-07 30.9 1.5 7.5 6 3 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12255.1 - 4.4e-16 59.0 2.5 0.0014 18.9 0.0 5.2 3 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12255.1 - 1.3e-11 43.9 6.5 0.015 14.0 0.5 5.1 4 1 1 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12255.1 - 7.8e-07 28.7 7.1 0.0016 17.9 0.4 4.7 2 2 2 5 5 5 3 WD40-like domain fn3_PAP PF17808.1 ETO12255.1 - 0.028 14.5 2.0 22 5.2 0.1 4.0 2 2 2 4 4 4 0 Fn3-like domain from Purple Acid Phosphatase Ac76 PF05814.11 ETO12256.1 - 0.0082 16.1 0.5 0.0082 16.1 0.5 2.4 2 0 0 2 2 2 1 Orf76 (Ac76) SpoIIIAH PF12685.7 ETO12256.1 - 0.015 15.1 0.1 0.072 12.9 0.0 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein Peptidase_S49_N PF08496.10 ETO12256.1 - 0.027 14.5 0.0 0.027 14.5 0.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4834 PF16118.5 ETO12256.1 - 0.036 15.0 0.3 0.036 15.0 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SARAF PF06682.12 ETO12256.1 - 0.056 13.1 0.1 0.086 12.5 0.1 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Baculo_11_kDa PF06143.11 ETO12256.1 - 0.18 11.4 5.2 0.46 10.1 5.2 1.7 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF2615 PF11027.8 ETO12256.1 - 0.26 11.4 0.0 0.26 11.4 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) EphA2_TM PF14575.6 ETO12256.1 - 0.56 11.1 9.0 0.16 12.9 3.8 2.6 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Tmemb_9 PF05434.11 ETO12256.1 - 1.2 9.0 6.9 0.084 12.8 1.6 1.7 2 0 0 2 2 2 0 TMEM9 Connexin PF00029.19 ETO12256.1 - 2.8 7.7 5.7 1.7 8.3 0.2 2.2 2 0 0 2 2 2 0 Connexin TMEM154 PF15102.6 ETO12256.1 - 3 7.8 8.2 0.14 12.1 1.9 2.1 2 0 0 2 2 2 0 TMEM154 protein family Kinesin PF00225.23 ETO12257.1 - 0.00015 20.8 1.4 0.00017 20.6 0.0 1.8 2 0 0 2 2 2 1 Kinesin motor domain TMF_DNA_bd PF12329.8 ETO12257.1 - 0.045 13.7 0.5 0.045 13.7 0.5 3.8 4 0 0 4 4 4 0 TATA element modulatory factor 1 DNA binding ADIP PF11559.8 ETO12257.1 - 0.051 13.7 14.7 0.31 11.1 8.8 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Peptidase_A6 PF01829.16 ETO12257.1 - 0.23 10.8 0.0 0.33 10.2 0.0 1.2 1 0 0 1 1 1 0 Peptidase A6 family NYD-SP28 PF14772.6 ETO12257.1 - 0.5 10.4 19.9 0.39 10.8 0.3 3.9 3 1 0 3 3 3 0 Sperm tail DUF1664 PF07889.12 ETO12257.1 - 3 7.9 6.5 2.9 7.9 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4665 PF15679.5 ETO12257.1 - 4.5 8.0 9.2 0.22 12.1 0.8 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4665) Exo_endo_phos_2 PF14529.6 ETO12258.1 - 0.046 13.6 0.7 0.097 12.5 0.0 1.9 3 0 0 3 3 3 0 Endonuclease-reverse transcriptase WD40 PF00400.32 ETO12259.1 - 6.3e-63 207.2 17.0 1.3e-09 38.5 1.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12259.1 - 4.1e-21 75.1 3.7 0.0018 18.5 0.2 6.5 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12259.1 - 5.7e-18 65.0 0.2 0.0066 15.4 0.0 6.8 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO12259.1 - 1.8e-09 37.7 0.6 0.16 11.8 0.0 3.7 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12259.1 - 4e-08 33.0 3.3 2.2 8.3 0.0 5.7 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO12259.1 - 1.7e-07 30.9 0.2 0.019 14.3 0.0 3.8 1 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO12259.1 - 2.2e-07 30.0 7.6 0.2 10.3 0.0 5.4 1 1 3 5 5 5 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO12259.1 - 3.5e-06 26.3 1.2 0.0083 15.2 0.1 3.0 1 1 2 3 3 3 2 Coatomer WD associated region Str_synth PF03088.16 ETO12259.1 - 0.00012 22.2 0.0 3.2 7.9 0.0 4.3 3 1 2 5 5 5 1 Strictosidine synthase PALB2_WD40 PF16756.5 ETO12259.1 - 0.00085 18.3 6.8 3.5 6.5 0.0 5.0 1 1 4 6 6 6 1 Partner and localizer of BRCA2 WD40 domain DUF1258 PF06869.12 ETO12259.1 - 0.0011 18.5 1.0 2 7.8 0.1 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF1258) SBD PF17882.1 ETO12259.1 - 0.006 16.4 0.8 10 6.0 0.0 3.6 2 2 1 3 3 3 0 OAA-family lectin sugar binding domain DUF5570 PF17731.1 ETO12259.1 - 0.0063 16.6 3.0 12 6.0 0.1 4.8 2 2 3 5 5 5 0 Family of unknown function (DUF5570) PH_TFIIH PF08567.11 ETO12259.1 - 0.027 14.8 0.3 38 4.7 0.0 3.7 3 1 1 4 4 4 0 TFIIH p62 subunit, N-terminal domain PA14 PF07691.12 ETO12259.1 - 0.04 13.7 0.3 11 5.8 0.0 2.6 2 1 0 2 2 2 0 PA14 domain AcetylCoA_hyd_C PF13336.6 ETO12259.1 - 0.076 12.9 0.0 26 4.7 0.0 3.7 4 0 0 4 4 4 0 Acetyl-CoA hydrolase/transferase C-terminal domain Pam16 PF03656.13 ETO12259.1 - 0.084 12.9 0.0 0.37 10.8 0.0 2.0 3 0 0 3 3 3 0 Pam16 Colicin_Ia PF11504.8 ETO12259.1 - 0.64 10.2 3.3 79 3.5 0.0 4.3 5 0 0 5 5 4 0 Colicin Ia Proteasome_A_N PF10584.9 ETO12259.1 - 0.76 9.5 9.4 24 4.7 0.0 5.0 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF4999 PF16390.5 ETO12259.1 - 1.2 9.4 6.1 61 4.0 0.0 4.3 4 1 1 5 5 5 0 Domain of unknown function CAP_GLY PF01302.25 ETO12260.1 - 1.1e-26 92.6 9.2 1.1e-18 67.0 1.1 2.7 2 1 0 2 2 2 2 CAP-Gly domain DUF2615 PF11027.8 ETO12260.1 - 0.93 9.7 0.0 0.93 9.7 0.0 4.8 6 0 0 6 6 6 0 Protein of unknown function (DUF2615) ERAP1_C PF11838.8 ETO12261.1 - 7.6e-16 58.5 0.0 8.7e-16 58.3 0.0 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain WD40 PF00400.32 ETO12262.1 - 9.3e-25 86.4 19.3 1.4e-06 28.9 0.2 5.0 4 2 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO12262.1 - 7.3e-11 41.4 2.6 0.059 12.0 0.1 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO12262.1 - 3.5e-09 36.8 0.3 0.053 13.8 0.0 4.0 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO12262.1 - 5.4e-05 22.7 1.2 0.025 13.9 0.1 2.8 2 1 1 3 3 3 2 WD40-like domain WD40 PF00400.32 ETO12263.1 - 9e-12 45.3 4.3 6.9e-07 29.9 0.7 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO12263.1 - 0.0002 20.1 0.1 0.00025 19.8 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO12263.1 - 0.044 12.7 0.0 0.045 12.7 0.0 1.2 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain WD40 PF00400.32 ETO12264.1 - 2.3e-10 40.9 6.5 5.1e-08 33.4 1.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO12264.1 - 0.0002 20.8 0.4 0.00035 20.0 0.4 1.3 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO12264.1 - 0.0011 17.7 0.1 0.0013 17.5 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO12264.1 - 0.012 15.9 0.0 0.022 15.0 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO12265.1 - 0.038 14.9 0.2 0.076 13.9 0.2 1.5 1 0 0 1 1 1 0 WD domain, G-beta repeat SOBP PF15279.6 ETO12266.1 - 0.14 12.7 31.4 0.011 16.4 22.5 2.4 1 1 1 2 2 2 0 Sine oculis-binding protein FAIM1 PF06905.13 ETO12267.1 - 0.016 14.9 0.4 0.03 14.1 0.4 1.4 1 0 0 1 1 1 0 Fas apoptotic inhibitory molecule (FAIM1) adh_short PF00106.25 ETO12268.1 - 7e-35 120.3 0.0 2e-23 82.9 0.0 2.2 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO12268.1 - 8.3e-25 87.7 0.0 2.9e-18 66.3 0.0 2.5 3 0 0 3 3 3 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO12268.1 - 1.2e-05 25.3 0.0 2.3e-05 24.4 0.0 1.5 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO12268.1 - 0.00012 21.6 0.0 0.0002 20.9 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO12268.1 - 0.12 11.8 0.0 0.16 11.3 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase TPR_12 PF13424.6 ETO12269.1 - 2.5e-33 114.2 9.6 1e-13 51.3 0.1 4.3 1 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12269.1 - 1.3e-19 69.4 0.2 0.0027 17.5 0.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12269.1 - 2.7e-12 45.8 6.5 0.00071 19.4 0.1 6.5 5 1 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12269.1 - 3.6e-10 39.2 30.0 0.0007 19.3 1.2 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12269.1 - 6.4e-09 35.3 23.5 0.022 14.9 1.0 5.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12269.1 - 2.1e-08 33.7 23.4 0.00048 20.0 0.4 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12269.1 - 7.6e-05 23.2 0.0 0.26 12.2 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12269.1 - 0.00028 21.0 8.9 0.71 10.4 0.2 5.5 5 0 0 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO12269.1 - 0.0026 17.1 0.3 2.2 7.8 0.0 2.8 2 0 0 2 2 2 2 SHNi-TPR GH115_C PF17829.1 ETO12269.1 - 0.003 17.4 1.4 0.11 12.3 0.6 2.2 2 0 0 2 2 2 1 Gylcosyl hydrolase family 115 C-terminal domain SPO22 PF08631.10 ETO12269.1 - 0.035 13.6 0.0 0.086 12.3 0.0 1.6 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like DUF4404 PF14357.6 ETO12269.1 - 0.041 14.5 0.0 0.32 11.7 0.0 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4404) TPR_MalT PF17874.1 ETO12269.1 - 0.13 11.6 0.0 0.38 10.1 0.0 1.7 1 1 0 1 1 1 0 MalT-like TPR region DUF2225 PF09986.9 ETO12269.1 - 0.14 11.8 4.9 0.33 10.6 0.6 2.4 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO12269.1 - 0.2 11.8 4.7 5.7 7.1 0.0 4.0 4 0 0 4 4 3 0 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO12269.1 - 0.4 10.5 9.1 1.5 8.6 0.1 4.1 3 2 1 4 4 4 0 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO12269.1 - 0.55 11.0 3.6 39 5.2 0.1 3.9 4 0 0 4 4 3 0 Tetratricopeptide repeat PepSY_2 PF13670.6 ETO12270.1 - 0.77 9.8 3.1 1.2 9.2 3.1 1.2 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain ANAPC5 PF12862.7 ETO12271.1 - 5.3e-19 68.1 5.1 8.7e-19 67.4 3.9 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 5 TPR_20 PF14561.6 ETO12271.1 - 0.0019 18.5 1.4 3.2 8.1 0.1 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat Vpu PF00558.19 ETO12271.1 - 0.0058 16.4 0.4 0.033 14.0 0.1 2.2 1 1 1 2 2 2 1 Vpu protein TPR_12 PF13424.6 ETO12271.1 - 0.087 13.1 0.8 0.21 11.9 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat Folate_carrier PF01770.18 ETO12271.1 - 0.53 9.0 6.9 0.19 10.4 1.1 2.1 1 1 1 2 2 2 0 Reduced folate carrier Peptidase_S49_N PF08496.10 ETO12271.1 - 4.4 7.3 9.7 0.057 13.5 1.7 2.0 2 1 0 2 2 2 0 Peptidase family S49 N-terminal BTB PF00651.31 ETO12272.1 - 1.8e-21 76.4 5.3 3.7e-20 72.2 0.4 2.6 2 1 1 3 3 3 2 BTB/POZ domain BACK PF07707.15 ETO12272.1 - 1.2e-06 28.5 1.2 2.4e-05 24.4 0.1 3.0 3 1 1 4 4 4 1 BTB And C-terminal Kelch DUF4704 PF15787.5 ETO12272.1 - 0.00074 18.8 2.2 0.0038 16.5 0.1 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4704) DUF727 PF05303.12 ETO12272.1 - 0.0034 17.4 0.2 0.082 13.0 0.0 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF727) Ank_4 PF13637.6 ETO12273.1 - 0.00074 20.0 0.6 0.0099 16.4 0.3 2.3 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO12273.1 - 0.0033 18.0 0.0 0.0068 17.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Tho2 PF11262.8 ETO12273.1 - 0.21 10.8 1.8 0.37 10.0 0.0 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 UPRTase PF14681.6 ETO12274.1 - 8.8e-21 74.3 0.1 8.6e-18 64.5 0.0 3.0 2 1 0 2 2 2 2 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ETO12274.1 - 0.0094 15.5 0.0 0.022 14.3 0.0 1.6 2 0 0 2 2 2 1 Phosphoribosyl transferase domain DUF726 PF05277.12 ETO12275.1 - 3e-45 154.7 0.3 7.7e-28 97.4 0.1 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF726) DUF4642 PF15484.6 ETO12275.1 - 0.044 14.0 2.9 0.064 13.5 2.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4642) DUF417 PF04224.12 ETO12275.1 - 0.084 12.4 0.2 0.13 11.8 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function, DUF417 O-antigen_lig PF13425.6 ETO12275.1 - 0.22 10.3 0.9 0.26 10.0 0.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein GOLD_2 PF13897.6 ETO12275.1 - 0.45 11.0 2.1 0.32 11.5 0.3 1.6 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking Presenilin PF01080.17 ETO12275.1 - 0.46 9.2 2.4 0.61 8.8 2.4 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 ETO12275.1 - 3 7.9 7.5 6.1 6.9 7.7 1.5 1 1 0 1 1 1 0 DDHD domain PRC2_HTH_1 PF18118.1 ETO12275.1 - 9.1 7.1 11.1 93 3.9 11.1 2.1 1 1 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain DUF726 PF05277.12 ETO12276.1 - 1.1e-20 73.9 5.4 1.3e-16 60.5 2.5 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF726) DnaJ PF00226.31 ETO12277.1 - 2.4e-29 101.2 1.7 8.4e-29 99.5 1.7 2.0 1 0 0 1 1 1 1 DnaJ domain Benyvirus_14KDa PF07255.11 ETO12277.1 - 0.11 12.7 2.3 0.45 10.8 1.5 2.3 2 0 0 2 2 2 0 Benyvirus 14KDa protein Trypan_PARP PF05887.11 ETO12277.1 - 4.6 7.2 8.0 14 5.7 8.0 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FH2 PF02181.23 ETO12279.1 - 2.6e-47 161.8 8.0 3.5e-34 118.5 2.6 3.4 3 1 0 3 3 3 2 Formin Homology 2 Domain Matrilin_ccoil PF10393.9 ETO12279.1 - 0.0093 15.8 0.3 0.074 12.9 0.1 2.5 2 0 0 2 2 2 1 Trimeric coiled-coil oligomerisation domain of matrilin XRN_M PF17846.1 ETO12279.1 - 0.12 11.3 10.3 0.25 10.3 10.3 1.6 1 0 0 1 1 1 0 Xrn1 helical domain DUF908 PF06012.12 ETO12279.1 - 1 8.7 12.0 1.7 8.0 12.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) AA_kinase PF00696.28 ETO12281.1 - 1.8e-13 50.7 0.0 1.8e-12 47.4 0.0 2.2 1 1 1 3 3 3 1 Amino acid kinase family Neur_chan_LBD PF02931.23 ETO12282.1 - 0.0066 15.9 0.1 0.0085 15.6 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Rhodanese PF00581.20 ETO12283.1 - 0.00085 19.8 0.0 0.0016 18.9 0.0 1.6 1 1 0 1 1 1 1 Rhodanese-like domain PGM_PMM_I PF02878.16 ETO12283.1 - 0.0045 16.7 0.0 0.0069 16.1 0.0 1.2 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I UDPGP PF01704.18 ETO12284.1 - 3.6e-37 128.0 0.0 7.3e-37 127.0 0.0 1.4 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase MMR_HSR1 PF01926.23 ETO12284.1 - 9.7e-20 70.8 0.1 2.3e-19 69.5 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO12284.1 - 7.7e-07 29.2 0.1 0.005 16.8 0.0 2.6 2 0 0 2 2 2 2 RsgA GTPase FeoB_N PF02421.18 ETO12284.1 - 2.4e-06 27.2 0.1 4.6e-06 26.2 0.1 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B AIG1 PF04548.16 ETO12284.1 - 1.3e-05 24.7 0.0 3.3e-05 23.3 0.0 1.7 1 0 0 1 1 1 1 AIG1 family Arf PF00025.21 ETO12284.1 - 0.00033 20.2 0.4 0.95 8.9 0.2 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO12284.1 - 0.00064 19.1 0.6 0.0061 15.9 0.6 2.3 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ETO12284.1 - 0.049 13.8 0.2 0.59 10.4 0.0 2.6 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NTP_transf_3 PF12804.7 ETO12284.1 - 0.06 13.7 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 MobA-like NTP transferase domain ACCA PF03255.14 ETO12284.1 - 0.74 9.7 7.2 1.1 9.1 3.8 2.8 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit VPS13 PF16908.5 ETO12286.1 - 8e-18 65.1 6.2 3e-12 46.9 0.6 2.3 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal RXT2_N PF08595.11 ETO12286.1 - 0.0027 17.7 9.5 0.0061 16.6 9.5 1.7 1 0 0 1 1 1 1 RXT2-like, N-terminal Nop14 PF04147.12 ETO12286.1 - 0.018 13.3 10.6 0.023 13.0 10.6 1.1 1 0 0 1 1 1 0 Nop14-like family GCIP PF13324.6 ETO12286.1 - 0.18 11.4 7.1 0.32 10.6 7.1 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting CobT PF06213.12 ETO12286.1 - 0.27 10.6 9.9 0.41 10.0 9.9 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DNA_pol_phi PF04931.13 ETO12286.1 - 0.41 8.7 21.6 0.59 8.2 21.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi GEN1_C PF18380.1 ETO12286.1 - 0.42 11.5 5.9 0.45 11.4 3.8 2.1 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain CDC45 PF02724.14 ETO12286.1 - 1.3 7.2 17.6 0.32 9.2 14.5 1.5 2 0 0 2 2 2 0 CDC45-like protein FAM176 PF14851.6 ETO12286.1 - 4.3 7.0 14.1 4.3 7.0 12.4 1.7 1 1 0 1 1 1 0 FAM176 family Afi1 PF07792.12 ETO12286.1 - 6.3 7.3 17.8 1.2 9.6 13.2 2.1 1 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2076 PF09849.9 ETO12286.1 - 9.3 6.2 11.6 18 5.3 11.6 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SDA1 PF05285.12 ETO12286.1 - 9.3 5.6 22.1 14 5.0 22.1 1.3 1 1 0 1 1 1 0 SDA1 Brix PF04427.18 ETO12287.1 - 7.3e-28 98.0 1.6 2.3e-27 96.4 0.0 2.3 2 1 0 2 2 2 1 Brix domain RR_TM4-6 PF06459.12 ETO12287.1 - 0.06 13.2 19.8 0.036 13.9 4.4 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO12287.1 - 0.34 9.1 19.3 0.0045 15.4 8.4 2.1 2 0 0 2 2 2 0 CDC45-like protein Dicty_REP PF05086.12 ETO12287.1 - 0.42 8.5 21.9 0.053 11.5 13.2 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein CLN3 PF02487.17 ETO12287.1 - 0.56 9.2 6.6 0.31 10.0 0.2 2.1 2 0 0 2 2 2 0 CLN3 protein Pox_Ag35 PF03286.14 ETO12287.1 - 2.3 8.0 28.8 0.082 12.7 11.5 2.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein SLC12 PF03522.15 ETO12287.1 - 4.1 6.3 22.0 0.56 9.2 8.3 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Vfa1 PF08432.10 ETO12287.1 - 5.2 7.4 27.4 1.1 9.5 10.1 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO12287.1 - 6.6 6.4 12.6 1.7 8.4 0.9 2.3 2 0 0 2 2 2 0 Connexin Presenilin PF01080.17 ETO12287.1 - 9 4.9 22.1 0.64 8.7 7.8 2.2 2 0 0 2 2 2 0 Presenilin YL1 PF05764.13 ETO12288.1 - 0.00019 21.6 18.6 0.00027 21.2 18.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein SDA1 PF05285.12 ETO12288.1 - 0.0009 18.8 23.6 0.0011 18.4 23.6 1.1 1 0 0 1 1 1 1 SDA1 SLC12 PF03522.15 ETO12288.1 - 0.02 13.9 13.5 0.024 13.7 13.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Tim54 PF11711.8 ETO12288.1 - 0.031 13.1 7.3 0.047 12.5 7.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Mem_trans PF03547.18 ETO12288.1 - 0.044 12.2 0.2 0.065 11.6 0.2 1.3 1 0 0 1 1 1 0 Membrane transport protein V_ATPase_I PF01496.19 ETO12288.1 - 0.057 11.3 13.7 0.23 9.3 5.9 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF2722 PF10846.8 ETO12288.1 - 0.27 10.1 19.5 0.36 9.7 19.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CDC45 PF02724.14 ETO12288.1 - 0.42 8.8 21.1 0.59 8.4 21.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Membralin PF09746.9 ETO12288.1 - 0.44 9.5 4.7 0.59 9.1 4.7 1.3 1 0 0 1 1 1 0 Tumour-associated protein RR_TM4-6 PF06459.12 ETO12288.1 - 0.96 9.2 19.6 1.4 8.7 19.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 ETO12288.1 - 2.1 6.3 13.9 2.8 6.0 13.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sec62 PF03839.16 ETO12288.1 - 2.9 7.3 17.1 0.51 9.8 12.8 1.9 2 1 0 2 2 2 0 Translocation protein Sec62 Menin PF05053.13 ETO12288.1 - 4 5.7 14.7 5.3 5.3 14.7 1.1 1 0 0 1 1 1 0 Menin SID-1_RNA_chan PF13965.6 ETO12288.1 - 4.1 5.7 13.8 0.062 11.7 4.4 2.1 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 ALMT PF11744.8 ETO12288.1 - 7.3 5.3 12.3 10 4.8 12.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter SPRY PF00622.28 ETO12289.1 - 0.0013 18.8 0.1 0.005 17.0 0.1 2.1 1 1 0 1 1 1 1 SPRY domain BACK PF07707.15 ETO12289.1 - 0.0013 18.8 0.2 0.0029 17.7 0.2 1.5 1 0 0 1 1 1 1 BTB And C-terminal Kelch CDC45 PF02724.14 ETO12289.1 - 0.05 11.9 1.5 0.08 11.2 1.5 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO12289.1 - 0.14 10.4 6.3 0.2 9.8 6.3 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO12289.1 - 7.7 5.8 9.3 12 5.2 9.3 1.2 1 0 0 1 1 1 0 SDA1 V-SNARE_C PF12352.8 ETO12290.1 - 5.7e-05 23.3 3.2 5.7e-05 23.3 3.2 2.5 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus DUF1761 PF08570.10 ETO12290.1 - 0.0021 18.3 3.3 0.082 13.2 3.3 2.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1761) Sec20 PF03908.13 ETO12290.1 - 0.068 13.1 0.2 0.068 13.1 0.2 3.7 4 0 0 4 4 4 0 Sec20 EzrA PF06160.12 ETO12290.1 - 0.67 8.1 5.9 2.3 6.3 5.9 1.7 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA LAT PF15234.6 ETO12291.1 - 0.13 12.0 0.0 0.16 11.6 0.0 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells WD40 PF00400.32 ETO12292.1 - 8.6e-36 121.4 19.2 1.2e-07 32.3 1.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12292.1 - 0.00043 20.5 0.8 5.7 7.3 0.1 4.3 2 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO12292.1 - 0.01 15.2 0.0 0.059 12.7 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain UCH PF00443.29 ETO12294.1 - 1.5e-21 77.0 0.2 1.5e-21 77.0 0.2 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO12294.1 - 8.8e-09 35.4 0.1 8.8e-09 35.4 0.1 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO12295.1 - 3.5e-08 33.3 0.4 1.8e-06 27.7 3.0 2.5 2 2 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Vfa1 PF08432.10 ETO12295.1 - 0.011 16.1 4.7 0.011 16.1 4.7 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_E_B PF04042.16 ETO12295.1 - 0.013 14.8 0.0 0.047 13.0 0.0 1.9 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B UCH_1 PF13423.6 ETO12295.1 - 0.063 12.9 2.9 0.16 11.5 2.9 1.9 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase USP7_ICP0_bdg PF12436.8 ETO12296.1 - 0.034 13.5 0.1 0.079 12.3 0.1 1.5 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 UN_NPL4 PF11543.8 ETO12296.1 - 0.11 12.9 0.0 0.54 10.8 0.0 2.1 2 0 0 2 2 2 0 Nuclear pore localisation protein NPL4 NodA PF02474.15 ETO12296.1 - 0.14 11.9 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein A (NodA) DUF2542 PF10808.8 ETO12297.1 - 0.0069 16.8 0.0 0.019 15.4 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2542) G-alpha PF00503.20 ETO12298.1 - 1.9e-62 211.5 13.1 3.6e-61 207.3 13.1 2.0 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO12298.1 - 0.0005 19.6 4.4 0.00077 19.0 0.9 2.7 2 2 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO12298.1 - 0.0046 16.5 3.9 0.98 8.9 0.0 3.5 2 1 2 4 4 4 2 Elongation factor Tu GTP binding domain DUF3605 PF12239.8 ETO12298.1 - 0.012 16.0 1.3 0.8 10.0 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3605) RyR PF02026.16 ETO12298.1 - 0.041 14.1 0.1 0.12 12.5 0.1 1.8 1 1 0 1 1 1 0 RyR domain WD40 PF00400.32 ETO12299.1 - 1.1e-30 105.2 2.3 3.9e-06 27.5 0.0 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12299.1 - 4.2e-11 43.0 0.1 0.0035 17.6 0.0 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12299.1 - 2.1e-06 26.7 2.0 0.23 10.0 0.2 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO12299.1 - 5.6e-06 26.4 0.1 1.4e-05 25.1 0.1 1.6 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO12299.1 - 0.0028 16.7 0.2 1 8.2 0.0 2.9 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12299.1 - 0.0041 16.5 0.2 0.23 10.8 0.1 2.0 1 1 0 2 2 2 2 WD40-like domain PALB2_WD40 PF16756.5 ETO12299.1 - 0.04 12.9 1.5 1.6 7.6 0.1 2.6 1 1 2 3 3 3 0 Partner and localizer of BRCA2 WD40 domain WD40 PF00400.32 ETO12300.1 - 1.6e-10 41.4 17.9 0.23 12.4 0.4 7.9 8 0 0 8 8 8 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12300.1 - 1.4e-06 28.5 6.1 0.23 11.8 0.1 6.1 4 1 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 ETO12300.1 - 0.00016 21.4 0.1 0.037 13.9 0.0 3.5 3 0 0 3 3 3 1 PQQ enzyme repeat SGL PF08450.12 ETO12300.1 - 0.00036 20.2 0.3 0.017 14.7 0.1 3.1 3 1 0 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Pyrid_ox_like PF16242.5 ETO12300.1 - 0.015 14.9 0.2 0.18 11.4 0.1 2.2 1 1 1 2 2 2 0 Pyridoxamine 5'-phosphate oxidase like PQQ_3 PF13570.6 ETO12300.1 - 0.019 15.5 0.0 92 3.7 0.0 4.6 4 0 0 4 4 4 0 PQQ-like domain bacHORMA_2 PF18173.1 ETO12301.1 - 0.12 12.3 0.0 0.25 11.2 0.0 1.5 1 0 0 1 1 1 0 Bacterial HORMA domain 2 SpoOE-like PF09388.10 ETO12302.1 - 0.16 11.9 0.5 0.16 11.9 0.5 1.9 2 0 0 2 2 2 0 Spo0E like sporulation regulatory protein DUF383 PF04063.14 ETO12305.1 - 0.098 12.3 0.0 0.14 11.8 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF383) WD40 PF00400.32 ETO12306.1 - 6.5e-29 99.6 28.5 4e-08 33.8 0.5 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO12306.1 - 1.2e-06 27.5 6.1 0.071 11.7 0.3 4.3 4 1 1 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO12306.1 - 5.2e-06 26.7 0.2 0.045 14.1 0.1 4.1 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Comm PF15957.5 ETO12307.1 - 0.006 16.9 0.0 0.017 15.4 0.0 1.8 1 0 0 1 1 1 1 Commissureless FAM176 PF14851.6 ETO12307.1 - 0.027 14.1 0.0 0.027 14.1 0.0 3.0 2 1 0 2 2 1 0 FAM176 family S1FA PF04689.13 ETO12307.1 - 0.032 14.4 1.7 0.15 12.2 1.7 2.2 1 1 0 1 1 1 0 DNA binding protein S1FA SOG2 PF10428.9 ETO12307.1 - 0.28 10.4 12.3 0.35 10.0 12.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MAP17 PF15807.5 ETO12307.1 - 0.35 11.1 0.0 0.35 11.1 0.0 2.9 2 1 1 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EphA2_TM PF14575.6 ETO12307.1 - 0.55 11.2 6.7 0.67 10.9 0.0 3.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 ETO12307.1 - 0.57 11.2 0.0 0.57 11.2 0.0 3.3 2 1 0 2 2 1 0 Domain of unknown function (DUF4834) Miga PF10265.9 ETO12307.1 - 1.3 8.0 8.9 0.086 11.8 0.4 1.9 1 1 1 2 2 2 0 Mitoguardin V_ATPase_I PF01496.19 ETO12307.1 - 1.7 6.5 8.1 1.2 6.9 0.1 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family UPF0239 PF06783.11 ETO12307.1 - 2.8 8.2 10.1 0.91 9.7 0.1 2.9 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0239) WASH-7_C PF14746.6 ETO12307.1 - 7.2 6.3 6.9 0.26 11.0 0.1 2.1 2 1 0 2 2 1 0 WASH complex subunit 7, C-terminal Conotoxin PF02950.17 ETO12307.1 - 8.9 7.4 10.6 2.7 9.0 0.4 3.3 2 2 0 2 2 2 0 Conotoxin DnaJ PF00226.31 ETO12308.1 - 7.3e-22 77.3 0.4 1.3e-21 76.4 0.4 1.4 1 0 0 1 1 1 1 DnaJ domain Sulfotransfer_3 PF13469.6 ETO12309.1 - 0.0017 18.7 0.0 0.012 16.1 0.0 2.1 2 0 0 2 2 2 1 Sulfotransferase family TraE PF05309.11 ETO12309.1 - 0.1 12.0 0.0 0.22 10.9 0.0 1.5 1 0 0 1 1 1 0 TraE protein C2 PF00168.30 ETO12310.1 - 5.3e-53 177.6 5.7 1.3e-18 67.2 0.0 5.1 4 1 0 4 4 4 4 C2 domain PTEN_C2 PF10409.9 ETO12310.1 - 0.027 14.2 0.1 0.14 11.9 0.2 2.2 2 0 0 2 2 2 0 C2 domain of PTEN tumour-suppressor protein Ferlin_C PF16165.5 ETO12310.1 - 0.22 11.4 0.0 0.22 11.4 0.0 3.3 2 1 0 2 2 2 0 Ferlin C-terminus WD40 PF00400.32 ETO12311.1 - 1.9e-52 174.1 10.2 1.1e-10 41.8 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12311.1 - 4.4e-17 62.2 0.6 1.3e-05 25.4 0.0 4.5 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12311.1 - 1.3e-11 44.1 0.3 0.0097 14.9 0.0 4.6 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO12311.1 - 1.8e-09 36.8 2.0 0.12 11.0 0.1 4.0 2 2 2 4 4 4 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO12311.1 - 1.6e-05 24.7 0.8 2.2 8.3 0.1 3.7 4 0 0 4 4 3 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO12311.1 - 2.3e-05 23.1 0.1 0.12 10.9 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO12311.1 - 6.3e-05 22.4 0.1 0.24 10.7 0.0 2.9 2 1 0 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 ETO12311.1 - 0.00024 20.0 1.7 0.2 10.4 0.0 3.3 1 1 2 3 3 3 2 Nup133 N terminal like DUF5570 PF17731.1 ETO12311.1 - 0.00039 20.5 0.5 0.48 10.5 0.0 3.4 1 1 3 4 4 4 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO12311.1 - 0.0024 17.2 0.3 0.59 9.4 0.1 3.0 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal BBS2_Mid PF14783.6 ETO12311.1 - 0.003 17.6 0.8 24 5.0 0.0 3.8 3 1 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region HARP PF07443.13 ETO12311.1 - 0.0059 16.2 0.0 1.2 8.8 0.0 3.1 4 0 0 4 4 4 1 HepA-related protein (HARP) Arena_nucleocap PF00843.17 ETO12311.1 - 0.019 13.9 0.1 5.4 5.8 0.0 3.0 2 1 1 3 3 3 0 Arenavirus nucleocapsid N-terminal domain Proteasome_A_N PF10584.9 ETO12311.1 - 2.4 7.9 11.0 3.3 7.5 0.0 4.3 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature MC1 PF05854.11 ETO12312.1 - 0.1 12.9 0.3 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 Non-histone chromosomal protein MC1 KIP1 PF07765.12 ETO12312.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.4 2 0 0 2 2 2 0 KIP1-like protein ACCA PF03255.14 ETO12312.1 - 1.8 8.4 7.4 0.27 11.1 2.6 2.2 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF948 PF06103.11 ETO12312.1 - 6.9 7.0 10.2 14 6.0 0.7 3.7 3 1 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Chromo PF00385.24 ETO12313.1 - 3e-09 36.7 2.4 7.5e-09 35.4 2.4 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Nuc_sug_transp PF04142.15 ETO12314.1 - 5.8e-36 124.3 17.4 8.5e-36 123.7 17.4 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ETO12314.1 - 8.1e-07 29.3 24.3 0.0013 18.9 6.4 2.4 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ETO12314.1 - 6.9e-05 22.2 10.2 6.9e-05 22.2 10.2 2.2 2 1 0 2 2 2 1 Purine nucleobase transmembrane transport DUF4131 PF13567.6 ETO12314.1 - 0.023 14.3 0.3 1.6 8.4 0.1 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4131) UPF0182 PF03699.13 ETO12314.1 - 0.6 8.2 6.7 0.26 9.4 2.9 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0182) DEAD PF00270.29 ETO12315.1 - 1.1e-05 25.3 0.2 2.9e-05 23.9 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase AAA_29 PF13555.6 ETO12315.1 - 0.11 12.3 0.1 0.23 11.2 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain cobW PF02492.19 ETO12315.1 - 0.12 12.0 0.0 0.24 11.0 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_30 PF13604.6 ETO12315.1 - 0.12 12.1 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO12315.1 - 0.24 11.9 0.5 0.66 10.5 0.1 1.9 2 0 0 2 2 2 0 ABC transporter DLIC PF05783.11 ETO12315.1 - 4.2 6.1 8.8 0.3 9.9 0.1 2.1 2 0 0 2 2 2 0 Dynein light intermediate chain (DLIC) DUF5385 PF17359.2 ETO12317.1 - 0.0024 17.4 1.8 0.0024 17.4 1.8 2.6 2 1 0 2 2 2 1 Family of unknown function (DUF5385) DUF2615 PF11027.8 ETO12317.1 - 0.0052 16.9 4.0 0.0052 16.9 4.0 3.4 3 1 1 4 4 4 1 Protein of unknown function (DUF2615) OAD_gamma PF04277.13 ETO12317.1 - 0.007 16.9 4.8 0.037 14.6 0.1 2.4 2 0 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain EphA2_TM PF14575.6 ETO12317.1 - 0.046 14.6 0.1 0.046 14.6 0.1 3.3 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain PI3K_1B_p101 PF10486.9 ETO12317.1 - 0.059 11.2 20.2 0.071 10.9 20.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Conotoxin PF02950.17 ETO12317.1 - 0.12 13.4 0.3 0.12 13.4 0.3 3.4 1 1 1 3 3 3 0 Conotoxin Cadherin_C_2 PF16492.5 ETO12317.1 - 0.32 11.8 0.2 0.32 11.8 0.2 2.6 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal SARAF PF06682.12 ETO12317.1 - 5.1 6.7 22.9 11 5.5 22.9 1.7 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis GREB1 PF15782.5 ETO12317.1 - 9.3 3.2 28.4 11 2.9 28.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BRI3BP PF14965.6 ETO12318.1 - 0.062 12.8 0.1 0.098 12.2 0.1 1.3 1 0 0 1 1 1 0 Negative regulator of p53/TP53 LodA_N PF17990.1 ETO12319.1 - 0.11 12.4 4.3 0.16 11.9 4.3 1.2 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal GTP_EFTU PF00009.27 ETO12320.1 - 0.00015 21.4 0.1 0.00015 21.4 0.1 3.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Joubert PF15392.6 ETO12320.1 - 0.0034 17.2 26.8 0.0039 17.0 26.8 1.1 1 0 0 1 1 1 1 Joubert syndrome-associated SNase PF00565.17 ETO12321.1 - 1.4e-20 73.8 3.3 1.5e-09 38.2 0.1 3.6 3 0 0 3 3 3 2 Staphylococcal nuclease homologue CDC45 PF02724.14 ETO12321.1 - 0.55 8.5 15.2 1.1 7.4 15.2 1.5 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 ETO12321.1 - 0.76 9.4 21.0 0.047 13.4 15.4 1.8 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TFB6 PF17110.5 ETO12321.1 - 2.8 7.6 8.6 41 3.9 7.2 2.6 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH NOA36 PF06524.12 ETO12321.1 - 5.9 6.1 16.4 12 5.1 16.4 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO12321.1 - 9.5 4.2 19.5 15 3.5 19.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi TUDOR PF00567.24 ETO12322.1 - 3.1e-17 62.7 0.0 7.5e-17 61.5 0.0 1.7 1 0 0 1 1 1 1 Tudor domain SNase PF00565.17 ETO12322.1 - 1.1e-15 58.0 6.8 2.2e-10 41.0 0.0 4.2 4 1 0 4 4 4 3 Staphylococcal nuclease homologue GTP_EFTU PF00009.27 ETO12323.1 - 9.1e-34 116.7 0.0 1.2e-33 116.3 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETO12323.1 - 5.5e-11 42.8 0.0 4.9e-10 39.7 0.0 2.5 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETO12323.1 - 2.1e-05 24.8 0.1 4.1e-05 23.9 0.1 1.6 1 0 0 1 1 1 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETO12323.1 - 0.056 13.5 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase Sin3a_C PF16879.5 ETO12324.1 - 4.3e-10 39.8 8.5 3.9e-08 33.4 8.5 2.1 1 1 0 1 1 1 1 C-terminal domain of Sin3a protein UDG PF03167.19 ETO12324.1 - 0.079 12.9 0.0 0.1 12.6 0.0 1.3 1 0 0 1 1 1 0 Uracil DNA glycosylase superfamily Complex1_LYR_2 PF13233.6 ETO12324.1 - 0.11 13.3 0.2 0.33 11.7 0.2 1.9 1 1 0 1 1 1 0 Complex1_LYR-like DUF4834 PF16118.5 ETO12326.1 - 0.016 16.1 3.9 0.026 15.5 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Myb_DNA-binding PF00249.31 ETO12328.1 - 3.4e-05 24.0 0.0 0.00013 22.1 0.0 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO12328.1 - 4.3e-05 23.7 0.2 4.3e-05 23.7 0.2 2.7 2 0 0 2 2 2 1 Myb-like DNA-binding domain DUF4746 PF15928.5 ETO12328.1 - 0.28 10.5 14.8 0.49 9.8 14.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PRC2_HTH_1 PF18118.1 ETO12328.1 - 0.39 11.6 13.1 2.2 9.1 10.8 3.0 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain DUF853 PF05872.12 ETO12328.1 - 1.8 7.1 5.0 2.8 6.4 5.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) SLC12 PF03522.15 ETO12328.1 - 4.8 6.1 16.8 9.8 5.1 16.8 1.5 1 0 0 1 1 1 0 Solute carrier family 12 NOB1_Zn_bind PF08772.11 ETO12329.1 - 0.017 15.3 0.6 0.065 13.4 0.6 2.0 1 0 0 1 1 1 0 Nin one binding (NOB1) Zn-ribbon like Macoilin PF09726.9 ETO12329.1 - 2.2 6.7 8.6 2.3 6.7 8.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF2464 PF10240.9 ETO12330.1 - 0.026 14.1 1.4 0.035 13.7 1.4 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 NIBRIN_BRCT_II PF16508.5 ETO12331.1 - 0.043 14.1 1.0 0.18 12.2 0.2 2.0 2 0 0 2 2 2 0 Second BRCT domain on Nijmegen syndrome breakage protein SWIRM PF04433.17 ETO12331.1 - 0.055 13.8 0.1 0.17 12.2 0.1 1.8 1 0 0 1 1 1 0 SWIRM domain Nop14 PF04147.12 ETO12332.1 - 1.1 7.4 40.8 1.6 6.9 40.8 1.1 1 0 0 1 1 1 0 Nop14-like family Spem1 PF15670.5 ETO12332.1 - 1.4 8.4 14.8 2.8 7.5 14.8 1.4 1 0 0 1 1 1 0 Spermatid maturation protein 1 Dapper PF15268.6 ETO12332.1 - 8.9 5.0 21.8 12 4.5 21.8 1.1 1 0 0 1 1 1 0 Dapper CTP_transf_1 PF01148.20 ETO12335.1 - 1.6e-18 67.5 0.3 1.9e-18 67.2 0.3 1.1 1 0 0 1 1 1 1 Cytidylyltransferase family RXLR PF16810.5 ETO12336.1 - 0.046 14.1 1.2 0.066 13.6 1.2 1.2 1 0 0 1 1 1 0 RXLR phytopathogen effector protein, Avirulence activity DUF3991 PF13154.6 ETO12336.1 - 0.12 12.7 0.2 0.22 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3991) Dicty_REP PF05086.12 ETO12338.1 - 0.00079 17.5 2.8 0.0011 17.1 2.8 1.2 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein TCP PF03634.13 ETO12338.1 - 3.2 8.3 10.1 0.94 10.0 6.4 1.9 2 0 0 2 2 2 0 TCP family transcription factor WD40 PF00400.32 ETO12339.1 - 7.3e-06 26.6 1.4 0.012 16.4 0.4 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat Kelch_2 PF07646.15 ETO12340.1 - 3.5e-08 33.1 3.2 0.00013 21.8 0.2 5.0 6 1 0 6 6 6 1 Kelch motif Kelch_6 PF13964.6 ETO12340.1 - 1.1e-06 28.6 0.4 0.27 11.6 0.1 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO12340.1 - 4.2e-06 26.2 0.1 0.0016 18.0 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO12340.1 - 0.0019 18.4 0.2 0.32 11.3 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO12340.1 - 0.0065 16.4 0.1 1.7 8.7 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO12340.1 - 0.0069 16.3 2.3 1.1 9.4 0.1 4.0 5 0 0 5 5 5 1 Kelch motif RVT_1 PF00078.27 ETO12343.1 - 0.00047 19.8 0.0 0.00079 19.0 0.0 1.3 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Peripla_BP_2 PF01497.18 ETO12343.1 - 0.027 14.0 0.0 0.056 13.0 0.0 1.4 1 0 0 1 1 1 0 Periplasmic binding protein zf-BED PF02892.15 ETO12343.1 - 0.1 12.6 0.1 0.32 11.1 0.1 1.8 1 0 0 1 1 1 0 BED zinc finger Helicase_C PF00271.31 ETO12345.1 - 6.7e-19 68.3 0.2 1.6e-18 67.1 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ETO12345.1 - 4.4e-06 26.1 0.0 0.00044 19.5 0.0 2.8 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 SnAC PF14619.6 ETO12345.1 - 0.12 13.0 0.3 0.24 12.0 0.3 1.6 1 0 0 1 1 1 0 Snf2-ATP coupling, chromatin remodelling complex Pyr_redox_2 PF07992.14 ETO12346.1 - 9.2e-17 61.2 0.0 2.8e-07 30.1 0.0 2.1 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO12346.1 - 0.15 11.2 0.0 0.23 10.5 0.0 1.2 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) eIF3g PF12353.8 ETO12349.1 - 2.3e-05 24.8 1.5 4.1e-05 24.0 1.5 1.4 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit G RRM_1 PF00076.22 ETO12349.1 - 0.0028 17.5 0.1 0.076 12.8 0.1 2.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) COG6 PF06419.11 ETO12350.1 - 4.2e-14 51.7 0.1 4.9e-14 51.5 0.1 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 zf-RING_5 PF14634.6 ETO12352.1 - 0.00024 21.0 5.4 0.0004 20.3 5.4 1.3 1 0 0 1 1 1 1 zinc-RING finger domain Siva PF05458.12 ETO12352.1 - 0.016 14.9 3.0 0.016 14.9 3.0 1.7 1 1 1 2 2 2 0 Cd27 binding protein (Siva) Paired_CXXCH_1 PF09699.10 ETO12352.1 - 0.036 13.8 5.7 0.09 12.5 5.7 1.6 1 0 0 1 1 1 0 Doubled CXXCH motif (Paired_CXXCH_1) zf-RING_2 PF13639.6 ETO12352.1 - 0.066 13.6 6.9 0.1 12.9 6.9 1.3 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 ETO12352.1 - 0.12 12.5 5.6 0.28 11.2 5.6 1.7 1 1 0 1 1 1 0 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO12352.1 - 0.22 11.4 7.4 0.63 10.0 7.4 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO12352.1 - 0.99 9.3 7.8 2.2 8.2 7.8 1.6 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Svs_4_5_6 PF17381.2 ETO12352.1 - 5.9 7.9 10.7 1 10.3 5.7 2.1 2 0 0 2 2 2 0 Seminal vesicle secretory proteins 4/5/6 Presenilin PF01080.17 ETO12352.1 - 6.8 5.3 6.8 9.1 4.9 6.8 1.1 1 0 0 1 1 1 0 Presenilin Ras PF00071.22 ETO12354.1 - 1.1e-30 106.4 0.0 1.6e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO12354.1 - 1.6e-12 47.7 0.0 3.7e-12 46.5 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO12354.1 - 2.4e-05 23.9 0.0 3.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO12354.1 - 0.002 17.7 0.0 0.036 13.6 0.0 2.1 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO12354.1 - 0.074 13.1 0.0 0.17 12.0 0.0 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase DAP3 PF10236.9 ETO12354.1 - 0.09 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 DLIC PF05783.11 ETO12354.1 - 0.69 8.7 2.9 5.9 5.6 0.8 2.6 1 1 2 3 3 3 0 Dynein light intermediate chain (DLIC) Ran_BP1 PF00638.18 ETO12355.1 - 1.3e-10 41.6 0.1 2.5e-10 40.7 0.1 1.4 1 0 0 1 1 1 1 RanBP1 domain MHC_I PF00129.18 ETO12357.1 - 0.046 13.3 1.8 0.073 12.6 1.8 1.3 1 0 0 1 1 1 0 Class I Histocompatibility antigen, domains alpha 1 and 2 Tmemb_cc2 PF10267.9 ETO12358.1 - 0.86 8.7 5.3 1.3 8.1 0.8 2.1 2 0 0 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein DNA_ligase_A_M PF01068.21 ETO12360.1 - 4.2e-59 199.6 0.1 4.2e-59 199.6 0.1 2.4 3 0 0 3 3 3 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ETO12360.1 - 1.3e-30 107.0 0.2 1.3e-30 107.0 0.2 2.4 3 0 0 3 3 3 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ETO12360.1 - 2.2e-14 53.9 0.0 9.4e-14 51.8 0.0 2.2 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region zf-CCHH PF10283.9 ETO12360.1 - 9.6e-09 35.1 1.3 1.9e-08 34.1 1.3 1.5 1 0 0 1 1 1 1 PBZ domain RNA_ligase PF09414.10 ETO12360.1 - 1.1e-06 29.1 1.3 1.8e-06 28.4 0.1 2.0 2 0 0 2 2 2 1 RNA ligase mRNA_cap_enzyme PF01331.19 ETO12360.1 - 0.0035 17.2 0.3 0.027 14.3 0.0 2.6 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain Tubulin_C PF03953.17 ETO12361.1 - 1.3e-42 144.9 0.2 2.8e-42 143.9 0.2 1.6 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO12361.1 - 1.2e-24 87.6 0.0 3.3e-24 86.2 0.0 1.7 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO12361.1 - 0.0045 16.2 0.0 0.016 14.4 0.0 1.8 2 0 0 2 2 2 1 Tubulin like NACHT PF05729.12 ETO12362.1 - 1.4e-09 38.1 0.0 2.9e-09 37.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO12362.1 - 4.6e-06 27.2 1.2 1.8e-05 25.3 0.0 2.7 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO12362.1 - 0.0029 17.9 0.2 0.019 15.3 0.1 2.5 2 1 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ETO12362.1 - 0.0049 16.9 3.8 0.0067 16.5 0.5 2.6 1 1 1 2 2 2 1 AAA domain SLATT_5 PF18160.1 ETO12362.1 - 0.022 14.1 8.6 0.46 9.8 0.5 3.3 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 ABC_tran PF00005.27 ETO12362.1 - 0.039 14.5 0.7 0.17 12.4 0.1 2.4 2 1 0 2 2 2 0 ABC transporter ATPase PF06745.13 ETO12362.1 - 0.065 12.6 0.4 0.81 9.0 0.0 2.7 3 0 0 3 3 3 0 KaiC AAA_16 PF13191.6 ETO12362.1 - 0.13 12.6 0.0 0.48 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain WD40 PF00400.32 ETO12363.1 - 4.9e-124 400.6 54.4 4.6e-10 39.9 0.2 15.0 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12363.1 - 1.1e-51 173.0 7.7 0.00064 20.0 0.0 14.0 1 1 13 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12363.1 - 9.7e-23 80.6 13.9 0.26 10.2 0.0 12.8 1 1 13 14 14 14 9 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12363.1 - 1.1e-21 77.5 10.8 0.00015 21.2 0.1 9.2 3 2 5 9 9 9 5 WD40-like domain eIF2A PF08662.11 ETO12363.1 - 1.1e-21 77.6 0.0 0.002 18.0 0.0 6.3 1 1 5 6 6 6 6 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12363.1 - 7.1e-16 57.7 33.4 1.5 8.9 0.1 13.8 15 0 0 15 15 15 5 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETO12363.1 - 1.5e-11 43.3 0.0 0.0067 14.8 0.0 6.6 2 1 4 8 8 8 3 WD repeat-containing and planar cell polarity effector protein Fritz CelD_N PF02927.14 ETO12363.1 - 9e-05 23.3 0.0 9.9 7.1 0.0 6.2 4 2 3 7 7 6 0 Cellulase N-terminal ig-like domain Cytochrom_D1 PF02239.16 ETO12363.1 - 0.00013 20.6 13.5 0.53 8.7 0.3 5.3 2 1 5 7 7 7 4 Cytochrome D1 heme domain PQQ PF01011.21 ETO12363.1 - 0.00013 21.7 0.0 98 3.1 0.0 7.8 9 0 0 9 9 9 0 PQQ enzyme repeat DUF4875 PF16175.5 ETO12363.1 - 0.00018 21.6 20.7 1.5 9.0 0.0 9.2 3 2 8 11 11 11 1 Domain of unknown function (DUF4875) DPPIV_N PF00930.21 ETO12363.1 - 0.0002 20.3 1.0 4 6.1 0.0 6.1 4 3 3 8 8 8 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pentapeptide PF00805.22 ETO12363.1 - 0.00023 20.7 1.0 0.00054 19.6 1.0 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) TolB_N PF04052.13 ETO12363.1 - 0.00083 19.5 0.6 1e+02 3.1 0.0 7.9 12 0 0 12 12 11 0 TolB amino-terminal domain DUF285 PF03382.14 ETO12363.1 - 0.0053 16.5 1.9 8.8 6.1 0.0 5.3 3 2 2 5 5 5 1 Mycoplasma protein of unknown function, DUF285 Pentapeptide_4 PF13599.6 ETO12363.1 - 0.0078 16.4 0.4 0.02 15.0 0.4 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO12363.1 - 0.02 15.0 1.4 0.052 13.7 1.4 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO12363.1 - 0.038 14.1 28.2 2.7 8.1 0.2 9.0 1 1 8 11 11 11 0 Family of unknown function (DUF5570) DUF2684 PF10885.8 ETO12363.1 - 0.061 13.4 0.1 0.8 9.9 0.0 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF2684) GspH PF12019.8 ETO12363.1 - 0.87 10.0 17.8 46 4.5 0.1 7.3 1 1 5 8 8 8 0 Type II transport protein GspH DUF3800 PF12686.7 ETO12364.1 - 0.66 10.6 4.0 0.93 10.1 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) DUF5463 PF17551.2 ETO12366.1 - 0.46 10.4 3.3 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5463) Pkinase PF00069.25 ETO12367.1 - 1.5e-20 73.7 0.0 1.9e-20 73.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12367.1 - 7.5e-08 32.0 0.0 2e-07 30.6 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase NTP_transf_2 PF01909.23 ETO12369.1 - 0.00012 22.3 0.0 0.0002 21.6 0.0 1.4 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO12369.1 - 0.081 13.0 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase ALMT PF11744.8 ETO12370.1 - 1 8.1 8.2 1.6 7.4 8.2 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Motilin_ghrelin PF04644.12 ETO12370.1 - 4.1 7.3 13.7 0.73 9.7 1.0 3.2 2 0 0 2 2 2 0 Motilin/ghrelin LRR_4 PF12799.7 ETO12371.1 - 5.7e-06 26.6 8.7 12 6.5 0.1 7.4 6 2 1 7 7 7 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO12371.1 - 7.3e-05 22.5 8.1 0.43 10.8 0.1 5.6 6 0 0 6 6 6 2 Leucine Rich repeat Carm_PH PF17888.1 ETO12371.1 - 0.00098 19.4 0.1 0.0039 17.5 0.1 2.0 1 0 0 1 1 1 1 Carmil pleckstrin homology domain LRR_8 PF13855.6 ETO12371.1 - 0.0034 17.1 8.5 0.021 14.6 0.5 5.4 7 1 0 7 7 7 1 Leucine rich repeat RVT_thumb PF06817.14 ETO12371.1 - 0.0045 16.8 2.5 0.17 11.7 0.2 3.7 5 0 0 5 5 5 1 Reverse transcriptase thumb domain LRR_1 PF00560.33 ETO12371.1 - 0.13 12.9 4.6 89 4.3 0.0 5.9 7 0 0 7 7 7 0 Leucine Rich Repeat TGBp3 PF02495.17 ETO12371.1 - 0.3 10.8 3.8 19 5.0 0.1 3.8 4 0 0 4 4 4 0 Triple gene block 3 U3_assoc_6 PF08640.11 ETO12374.1 - 1.1e-05 25.5 1.8 1.1e-05 25.5 1.8 2.7 3 0 0 3 3 3 1 U3 small nucleolar RNA-associated protein 6 Pollen_Ole_e_I PF01190.17 ETO12375.1 - 0.11 13.0 0.2 0.29 11.5 0.1 1.7 2 0 0 2 2 2 0 Pollen proteins Ole e I like TPR_1 PF00515.28 ETO12376.1 - 2.3e-64 210.8 31.8 9.9e-08 31.5 0.0 9.2 8 1 1 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 ETO12376.1 - 6.8e-62 204.9 21.6 3.3e-11 42.7 0.7 8.8 4 2 4 8 8 8 8 TPR repeat TPR_2 PF07719.17 ETO12376.1 - 5e-60 194.8 25.0 3.7e-07 29.8 0.0 8.9 8 1 1 9 9 9 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12376.1 - 5.5e-59 192.4 22.5 4.7e-09 36.0 0.3 8.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12376.1 - 2e-46 152.3 25.5 2.2e-05 24.3 0.0 9.2 8 1 1 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12376.1 - 3.1e-39 133.4 7.2 9.7e-10 38.9 0.0 6.5 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12376.1 - 1.6e-36 121.8 5.4 0.00025 21.6 0.0 8.3 1 1 7 8 8 8 7 Tetratricopeptide repeat TPR_12 PF13424.6 ETO12376.1 - 4.8e-35 119.7 23.3 1.2e-09 38.3 1.4 6.4 1 1 5 6 6 6 6 Tetratricopeptide repeat TPR_19 PF14559.6 ETO12376.1 - 1.1e-31 109.1 23.5 1.2e-08 35.4 4.2 5.3 2 1 2 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12376.1 - 4.2e-27 92.2 7.8 0.0094 15.9 0.0 8.4 8 1 0 8 8 8 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12376.1 - 6.7e-18 63.9 26.4 0.054 13.4 0.2 8.2 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_9 PF13371.6 ETO12376.1 - 2.1e-17 63.0 0.2 0.01 16.0 0.0 5.5 1 1 2 5 5 5 4 Tetratricopeptide repeat TPR_4 PF07721.14 ETO12376.1 - 1e-15 56.6 0.2 0.56 11.0 0.0 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO12376.1 - 3.8e-14 52.8 6.9 0.00014 21.4 0.2 3.9 1 1 3 4 4 4 4 MalT-like TPR region TPR_6 PF13174.6 ETO12376.1 - 1.3e-11 44.4 9.6 1 10.2 0.0 8.0 9 0 0 9 9 8 2 Tetratricopeptide repeat NARP1 PF12569.8 ETO12376.1 - 6.8e-11 41.8 8.6 0.034 13.1 0.1 4.2 1 1 2 4 4 4 4 NMDA receptor-regulated protein 1 FliD_C PF07195.12 ETO12376.1 - 5.5e-10 39.1 2.6 0.037 13.4 0.3 5.7 1 1 4 5 5 5 3 Flagellar hook-associated protein 2 C-terminus Fis1_TPR_C PF14853.6 ETO12376.1 - 6.5e-10 38.9 25.7 0.34 11.0 0.2 7.9 4 2 4 8 8 8 4 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ETO12376.1 - 4.4e-06 26.8 11.4 0.077 13.2 0.6 3.6 2 2 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 Endonuc-EcoRV PF09233.11 ETO12376.1 - 4.5e-06 26.2 1.2 0.75 9.1 0.0 4.6 1 1 4 6 6 6 2 Restriction endonuclease EcoRV DUF4810 PF16068.5 ETO12376.1 - 9.2e-06 26.1 16.2 2.6 8.7 0.1 6.8 3 3 4 7 7 7 1 Domain of unknown function (DUF4810) Alkyl_sulf_dimr PF14863.6 ETO12376.1 - 4.4e-05 23.9 13.9 1.3 9.4 0.4 5.9 1 1 4 5 5 5 1 Alkyl sulfatase dimerisation B_lectin PF01453.24 ETO12376.1 - 4.7e-05 23.9 0.6 0.8 10.3 0.1 3.7 2 1 1 4 4 4 1 D-mannose binding lectin EST1_DNA_bind PF10373.9 ETO12376.1 - 6.7e-05 22.5 10.8 0.45 9.9 0.1 6.1 7 1 1 8 8 8 2 Est1 DNA/RNA binding domain TPR_15 PF13429.6 ETO12376.1 - 0.00042 19.6 8.0 9.6 5.3 0.1 5.4 1 1 5 6 6 6 0 Tetratricopeptide repeat TOM20_plant PF06552.12 ETO12376.1 - 0.0035 17.1 8.1 3.4 7.4 0.0 5.2 1 1 4 5 5 5 1 Plant specific mitochondrial import receptor subunit TOM20 PPTA PF01239.22 ETO12376.1 - 0.014 15.1 18.9 34 4.4 0.1 7.6 8 0 0 8 8 8 0 Protein prenyltransferase alpha subunit repeat MIT PF04212.18 ETO12376.1 - 0.015 15.3 16.5 14 5.9 1.2 6.3 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain DUF5634 PF18681.1 ETO12376.1 - 0.02 15.3 2.4 5.6 7.4 0.2 4.1 2 2 1 4 4 4 0 Family of unknown function (DUF5634) FAT PF02259.23 ETO12376.1 - 0.071 12.3 7.8 9.1 5.4 0.1 4.8 1 1 5 6 6 6 0 FAT domain BTAD PF03704.17 ETO12376.1 - 0.1 13.0 4.1 3.7 8.0 1.5 3.1 1 1 1 3 3 3 0 Bacterial transcriptional activator domain HemY_N PF07219.13 ETO12376.1 - 0.16 12.2 12.0 24 5.2 1.2 6.0 1 1 4 6 6 6 0 HemY protein N-terminus DUF4192 PF13830.6 ETO12376.1 - 0.2 11.7 0.0 4.9 7.1 0.0 2.9 1 1 4 5 5 5 0 Domain of unknown function (DUF4192) Vta1_C PF18097.1 ETO12376.1 - 0.49 10.1 3.9 0.31 10.8 0.6 2.4 2 0 0 2 2 2 0 Vta1 C-terminal domain STT3_PglB_C PF18527.1 ETO12376.1 - 0.75 9.9 2.7 22 5.3 0.0 4.2 4 3 1 5 5 4 0 STT3/PglB C-terminal beta-barrel domain HemolysinCabind PF00353.19 ETO12377.1 - 1.4e-98 322.1 273.1 2.2e-10 40.3 12.8 18.4 12 6 3 18 18 18 16 RTX calcium-binding nonapeptide repeat (4 copies) Ribosomal_S5 PF00333.20 ETO12377.1 - 0.16 12.0 2.0 0.51 10.4 2.0 1.9 1 0 0 1 1 1 0 Ribosomal protein S5, N-terminal domain Mst1_SARAH PF11629.8 ETO12377.1 - 1.2 9.3 4.4 1.9 8.6 0.1 2.8 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 LZ3wCH PF18517.1 ETO12378.1 - 0.03 14.4 0.6 0.03 14.4 0.6 2.8 3 1 0 3 3 3 0 Leucine zipper with capping helix domain WD40 PF00400.32 ETO12380.1 - 9.4e-14 51.6 7.2 0.00024 21.9 0.1 3.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12380.1 - 0.017 15.4 0.1 8.3 6.8 0.0 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12380.1 - 0.049 12.3 0.3 0.5 8.9 0.3 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO12381.1 - 5.6e-46 153.6 20.2 1.1e-09 38.7 0.6 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12381.1 - 2.1e-17 63.2 2.2 0.0064 16.8 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12381.1 - 3.7e-10 39.3 0.3 4.3e-06 25.9 0.2 4.8 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12381.1 - 1.7e-06 27.6 0.2 0.031 13.6 0.0 3.1 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO12381.1 - 2.7e-06 26.3 6.3 0.031 12.9 0.3 5.0 1 1 5 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO12381.1 - 0.0019 18.1 3.9 0.25 11.3 0.5 3.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO12381.1 - 0.052 12.1 0.2 6.6 5.1 0.0 2.5 2 2 1 3 3 3 0 Cytochrome D1 heme domain Sulfotransfer_3 PF13469.6 ETO12382.1 - 1.2e-21 78.1 4.4 1.3e-19 71.4 4.4 2.7 1 1 0 1 1 1 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 ETO12382.1 - 2.2e-09 37.2 5.3 2.2e-09 37.2 5.3 3.3 1 1 2 3 3 2 2 Sulfotransferase domain GAGA_bind PF06217.12 ETO12382.1 - 0.00048 20.5 4.2 0.00077 19.8 4.2 1.3 1 0 0 1 1 1 1 GAGA binding protein-like family CSG2 PF16965.5 ETO12382.1 - 0.013 14.5 1.6 0.02 13.9 1.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 ETO12382.1 - 0.013 14.7 1.9 0.018 14.2 1.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 ETO12382.1 - 0.016 15.7 5.0 0.031 14.7 5.0 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Otopetrin PF03189.13 ETO12382.1 - 0.023 13.5 0.5 0.027 13.3 0.5 1.2 1 0 0 1 1 1 0 Otopetrin Menin PF05053.13 ETO12382.1 - 0.039 12.3 9.8 0.057 11.8 9.8 1.1 1 0 0 1 1 1 0 Menin CobT PF06213.12 ETO12382.1 - 0.1 12.0 10.0 0.17 11.3 10.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NPR3 PF03666.13 ETO12382.1 - 0.13 11.1 11.5 0.19 10.5 11.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 ETO12382.1 - 0.21 11.6 10.7 0.41 10.7 10.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF908 PF06012.12 ETO12382.1 - 0.24 10.8 7.7 0.42 10.0 7.7 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Ctr PF04145.15 ETO12382.1 - 0.24 12.0 1.1 0.59 10.7 0.3 2.1 2 0 0 2 2 2 0 Ctr copper transporter family EOS1 PF12326.8 ETO12382.1 - 0.25 11.3 5.5 0.61 10.0 5.5 1.7 1 0 0 1 1 1 0 N-glycosylation protein DUF3807 PF12720.7 ETO12382.1 - 0.53 10.5 20.5 0.038 14.2 15.5 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF3807) Med19 PF10278.9 ETO12382.1 - 0.54 10.2 18.9 0.033 14.1 13.3 1.8 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Mem_trans PF03547.18 ETO12382.1 - 0.71 8.2 3.1 1.1 7.6 3.1 1.2 1 0 0 1 1 1 0 Membrane transport protein Sulfotransfer_4 PF17784.1 ETO12382.1 - 0.82 9.4 10.8 1.2 8.9 7.7 2.6 2 1 0 2 2 2 0 Sulfotransferase domain PTPRCAP PF15713.5 ETO12382.1 - 1.3 9.3 10.1 3 8.1 10.1 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RR_TM4-6 PF06459.12 ETO12382.1 - 1.4 8.7 13.3 2.3 8.0 13.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Gti1_Pac2 PF09729.9 ETO12382.1 - 1.5 8.9 18.3 0.14 12.3 13.7 1.5 2 0 0 2 2 1 0 Gti1/Pac2 family Folliculin PF11704.8 ETO12382.1 - 1.5 8.6 7.1 1.5 8.6 4.4 2.0 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport CLN3 PF02487.17 ETO12382.1 - 2.3 7.2 5.3 3.6 6.5 5.3 1.3 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 ETO12382.1 - 3.6 7.3 11.1 1.2 8.9 7.9 1.8 2 0 0 2 2 2 0 Connexin MDFI PF15316.6 ETO12382.1 - 4.2 7.4 9.7 7.7 6.6 9.7 1.4 1 0 0 1 1 1 0 MyoD family inhibitor RP-C_C PF11800.8 ETO12382.1 - 4.5 7.3 9.5 1.4 9.0 6.7 1.5 2 0 0 2 2 2 0 Replication protein C C-terminal region CDC45 PF02724.14 ETO12382.1 - 5.3 5.2 16.5 7.8 4.7 16.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Coilin_N PF15862.5 ETO12382.1 - 5.6 6.8 23.4 0.18 11.6 16.6 1.9 3 0 0 3 3 1 0 Coilin N-terminus MDM10 PF12519.8 ETO12382.1 - 5.7 5.7 14.7 8.6 5.1 14.7 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Presenilin PF01080.17 ETO12382.1 - 6.2 5.5 15.2 9.4 4.9 15.2 1.2 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 ETO12382.1 - 7.3 6.7 12.7 14 5.8 12.7 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal YqfQ PF14181.6 ETO12382.1 - 7.6 6.7 15.6 12 6.0 15.6 1.3 1 0 0 1 1 1 0 YqfQ-like protein V_ATPase_I PF01496.19 ETO12382.1 - 7.6 4.3 15.3 1.2 7.0 11.1 1.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SR-25 PF10500.9 ETO12382.1 - 8.6 5.9 21.0 17 4.9 21.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein NDUF_C2 PF06374.11 ETO12383.1 - 0.0017 18.4 0.2 0.0048 17.0 0.2 1.8 1 0 0 1 1 1 1 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) HXXSHH PF07586.11 ETO12383.1 - 0.011 15.4 3.3 0.016 14.8 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) YcbB PF08664.10 ETO12383.1 - 0.017 15.2 2.8 0.017 15.2 2.8 2.1 1 1 1 2 2 2 0 YcbB domain Mt_ATP-synt_B PF05405.14 ETO12383.1 - 0.069 12.8 10.4 0.14 11.8 10.4 1.6 1 0 0 1 1 1 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) Pur_ac_phosph_N PF16656.5 ETO12383.1 - 0.12 13.0 1.0 0.37 11.4 0.1 2.2 1 1 1 2 2 2 0 Purple acid Phosphatase, N-terminal domain DegT_DnrJ_EryC1 PF01041.17 ETO12383.1 - 0.12 11.6 2.2 0.18 11.1 2.2 1.2 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family DUF4407 PF14362.6 ETO12383.1 - 0.25 10.7 7.8 0.34 10.2 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PIN_8 PF18476.1 ETO12383.1 - 0.58 10.0 15.0 0.075 12.9 10.8 1.6 2 0 0 2 2 2 0 PIN like domain SUI1 PF01253.22 ETO12384.1 - 6.4e-17 61.9 1.8 7.7e-17 61.6 1.8 1.1 1 0 0 1 1 1 1 Translation initiation factor SUI1 DUF5547 PF17701.1 ETO12384.1 - 0.11 12.4 0.2 0.26 11.1 0.3 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5547) cNMP_binding PF00027.29 ETO12385.1 - 2e-10 40.6 0.0 3.3e-10 39.9 0.0 1.4 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Thioredoxin_13 PF18401.1 ETO12385.1 - 0.033 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain SMC_N PF02463.19 ETO12386.1 - 0.0094 15.4 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain Gemini_C4 PF01492.17 ETO12386.1 - 0.091 12.7 1.0 0.17 11.8 0.2 1.8 2 0 0 2 2 2 0 Geminivirus C4 protein PHC2_SAM_assoc PF16616.5 ETO12386.1 - 0.11 13.3 1.0 0.16 12.8 1.0 1.3 1 1 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 PPR_3 PF13812.6 ETO12387.1 - 0.00064 19.7 0.2 0.0012 18.9 0.2 1.5 1 0 0 1 1 1 1 Pentatricopeptide repeat domain TMEM215 PF15746.5 ETO12387.1 - 0.059 12.8 0.1 0.077 12.5 0.1 1.1 1 0 0 1 1 1 0 TMEM215 family DUF3035 PF11233.8 ETO12387.1 - 0.072 13.4 0.0 0.11 12.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3035) Metallophos PF00149.28 ETO12388.1 - 2.6e-09 37.9 0.4 6.6e-08 33.3 0.0 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase DUF4780 PF16012.5 ETO12388.1 - 0.078 12.4 0.0 0.13 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4780) 7TM_GPCR_Sru PF10322.9 ETO12389.1 - 0.019 14.3 0.3 0.019 14.3 0.3 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru 7TM_GPCR_Srd PF10317.9 ETO12389.1 - 0.049 12.8 0.3 0.53 9.4 0.0 2.2 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srd DUF1772 PF08592.11 ETO12389.1 - 0.18 12.1 0.0 0.33 11.3 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) Transformer PF06495.11 ETO12389.1 - 0.28 11.3 43.6 0.49 10.5 13.0 2.3 2 0 0 2 2 2 0 Fruit fly transformer protein Baculo_11_kDa PF06143.11 ETO12389.1 - 2.5 7.7 8.9 0.17 11.5 0.4 3.0 2 1 1 3 3 3 0 Baculovirus 11 kDa family Presenilin PF01080.17 ETO12389.1 - 5.4 5.7 43.7 0.12 11.1 12.9 2.1 2 0 0 2 2 2 0 Presenilin Acatn PF13000.7 ETO12389.1 - 9.6 4.6 7.7 2.5 6.5 4.3 1.7 1 1 1 2 2 2 0 Acetyl-coenzyme A transporter 1 PH PF00169.29 ETO12390.1 - 4e-25 88.3 12.1 2.6e-15 56.8 0.2 3.9 4 1 0 4 4 4 3 PH domain PH_11 PF15413.6 ETO12390.1 - 5.4e-10 39.6 15.2 8.4e-05 23.0 0.6 4.4 4 0 0 4 4 4 3 Pleckstrin homology domain PH_8 PF15409.6 ETO12390.1 - 7.7e-08 32.5 9.8 0.0021 18.3 0.1 3.8 3 1 1 4 4 4 3 Pleckstrin homology domain PH_3 PF14593.6 ETO12390.1 - 4.5e-06 26.7 4.5 0.76 9.9 0.1 4.4 2 1 2 4 4 4 3 PH domain PH_13 PF16652.5 ETO12390.1 - 0.0021 17.9 0.0 0.098 12.5 0.0 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 ETO12390.1 - 0.063 13.6 0.0 1.5 9.2 0.0 2.5 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_4 PF15404.6 ETO12390.1 - 2.1 8.1 8.2 0.42 10.4 0.1 3.0 3 0 0 3 3 3 0 Pleckstrin homology domain DUF848 PF05852.11 ETO12391.1 - 0.11 12.6 5.7 0.14 12.2 5.3 1.5 1 1 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) DUF1003 PF06210.11 ETO12391.1 - 0.42 10.7 4.8 1 9.5 1.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1003) WD40 PF00400.32 ETO12393.1 - 3.3e-09 37.2 13.4 0.0006 20.6 0.4 5.3 4 2 0 4 4 4 3 WD domain, G-beta repeat VWA PF00092.28 ETO12394.1 - 7.3e-08 32.9 0.0 9.6e-08 32.5 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO12394.1 - 0.0084 16.1 0.0 0.01 15.8 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain GCIP PF13324.6 ETO12396.1 - 0.0025 17.5 0.4 1 8.9 0.0 2.2 2 0 0 2 2 2 2 Grap2 and cyclin-D-interacting DUF1053 PF06327.14 ETO12396.1 - 0.018 15.6 5.2 0.018 15.6 5.2 2.2 2 1 0 2 2 2 0 Domain of Unknown Function (DUF1053) TFA2_Winged_2 PF18121.1 ETO12396.1 - 0.042 13.5 0.0 0.18 11.5 0.1 2.1 2 1 0 2 2 2 0 TFA2 Winged helix domain 2 Innexin PF00876.18 ETO12396.1 - 0.043 13.1 2.2 0.048 12.9 0.0 1.9 2 0 0 2 2 2 0 Innexin DUF1465 PF07323.12 ETO12396.1 - 0.051 13.4 3.1 0.061 13.2 1.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1465) SAM_LFY PF01698.16 ETO12396.1 - 0.052 13.5 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Floricaula / Leafy protein SAM domain ApoLp-III PF07464.11 ETO12396.1 - 0.32 11.1 14.0 0.055 13.6 9.2 2.1 2 1 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) LMBR1 PF04791.16 ETO12396.1 - 0.39 9.6 6.4 0.46 9.3 6.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Serpin PF00079.20 ETO12398.1 - 1.6e-18 67.2 0.1 3.2e-11 43.2 0.0 2.1 2 0 0 2 2 2 2 Serpin (serine protease inhibitor) SDA1 PF05285.12 ETO12399.1 - 0.38 10.1 5.0 0.49 9.8 5.0 1.2 1 0 0 1 1 1 0 SDA1 HlyIII PF03006.20 ETO12400.1 - 8.6e-06 25.6 1.8 1.1e-05 25.3 1.8 1.1 1 0 0 1 1 1 1 Haemolysin-III related DUF4781 PF16013.5 ETO12400.1 - 0.1 11.4 0.2 0.13 11.1 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) HlyIII PF03006.20 ETO12401.1 - 2.2e-11 43.9 13.3 2.9e-11 43.5 13.3 1.2 1 0 0 1 1 1 1 Haemolysin-III related Vut_1 PF02592.15 ETO12401.1 - 3.8 7.8 12.9 5.9 7.2 12.9 1.3 1 0 0 1 1 1 0 Putative vitamin uptake transporter RtcB PF01139.17 ETO12402.1 - 2.2e-66 224.8 5.1 2.4e-34 119.2 0.6 3.6 2 2 1 3 3 3 2 tRNA-splicing ligase RtcB Lin-8 PF03353.15 ETO12402.1 - 0.24 10.9 14.2 0.36 10.3 14.2 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Macoilin PF09726.9 ETO12402.1 - 0.3 9.6 11.4 0.39 9.2 11.4 1.1 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 ETO12402.1 - 1.3 7.1 34.0 2.2 6.4 34.0 1.3 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 ETO12402.1 - 4.8 5.6 37.3 8 4.9 37.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GREB1 PF15782.5 ETO12402.1 - 5.5 4.0 13.8 7.5 3.5 13.8 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SDA1 PF05285.12 ETO12402.1 - 5.8 6.2 42.3 8.9 5.6 42.3 1.2 1 0 0 1 1 1 0 SDA1 Hid1 PF12722.7 ETO12402.1 - 7.2 4.6 13.7 9.8 4.2 13.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Mitofilin PF09731.9 ETO12403.1 - 2.3 6.9 24.9 2.9 6.6 24.9 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein SR-25 PF10500.9 ETO12403.1 - 4.7 6.7 28.6 3 7.4 27.0 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ndc1_Nup PF09531.10 ETO12403.1 - 5.3 5.6 13.5 6.1 5.4 13.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAML PF14963.6 ETO12403.1 - 5.3 7.1 17.7 7.4 6.6 17.6 1.2 1 1 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand PAP_central PF04928.17 ETO12404.1 - 0.089 11.8 0.1 0.1 11.5 0.1 1.1 1 0 0 1 1 1 0 Poly(A) polymerase central domain WD40 PF00400.32 ETO12405.1 - 4.5e-34 115.9 26.0 6.5e-06 26.8 0.2 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO12405.1 - 1.3e-09 37.3 7.5 0.0074 15.0 0.0 5.7 1 1 4 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO12405.1 - 2.3e-09 37.4 3.1 0.21 11.9 0.0 5.9 4 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain LepB_N PF18640.1 ETO12407.1 - 0.087 12.4 3.6 0.034 13.8 1.1 1.6 2 0 0 2 2 2 0 LepB N-terminal domain ALMT PF11744.8 ETO12407.1 - 0.12 11.2 9.4 0.15 10.8 9.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Ribosomal_S7 PF00177.21 ETO12407.1 - 0.12 12.0 6.4 0.36 10.5 0.3 2.2 2 0 0 2 2 2 0 Ribosomal protein S7p/S5e V_ATPase_I PF01496.19 ETO12407.1 - 7.8 4.3 15.9 2 6.2 1.2 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Terminase_4 PF05119.12 ETO12408.1 - 0.011 16.1 0.1 0.024 15.0 0.0 1.6 2 0 0 2 2 2 0 Phage terminase, small subunit CdiA_C_tRNase PF18664.1 ETO12408.1 - 0.03 14.5 0.1 0.038 14.2 0.1 1.4 1 1 0 1 1 1 0 CdiA C-terminal tRNase domain Proteasome PF00227.26 ETO12409.1 - 7.5e-24 84.3 0.1 2.2e-21 76.2 0.0 2.1 2 0 0 2 2 2 2 Proteasome subunit OTU PF02338.19 ETO12410.1 - 0.0038 17.7 0.3 0.0076 16.7 0.3 1.5 1 0 0 1 1 1 1 OTU-like cysteine protease Peptidase_C65 PF10275.9 ETO12410.1 - 0.0067 15.9 0.1 0.011 15.2 0.1 1.3 1 0 0 1 1 1 1 Peptidase C65 Otubain SH3_9 PF14604.6 ETO12410.1 - 0.007 16.2 0.2 4 7.4 0.1 2.5 2 0 0 2 2 2 2 Variant SH3 domain tRNA_anti_2 PF13742.6 ETO12410.1 - 0.065 13.4 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 OB-fold nucleic acid binding domain MBT PF02820.18 ETO12410.1 - 0.1 13.0 0.1 3.3 8.1 0.0 2.3 2 0 0 2 2 2 0 mbt repeat AAA_12 PF13087.6 ETO12414.1 - 1.2e-07 31.6 0.1 1.2e-06 28.3 0.0 2.3 2 0 0 2 2 2 1 AAA domain MTES_1575 PF18741.1 ETO12414.1 - 5.5e-06 26.5 0.0 1.3e-05 25.3 0.0 1.6 1 0 0 1 1 1 1 REase_MTES_1575 RAP PF08373.10 ETO12414.1 - 0.0013 18.8 1.2 0.0037 17.3 1.2 1.8 1 0 0 1 1 1 1 RAP domain DUF1064 PF06356.11 ETO12414.1 - 0.0017 18.7 0.2 0.0045 17.3 0.1 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1064) DUF559 PF04480.12 ETO12414.1 - 0.023 14.5 0.1 0.057 13.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF559) NST1 PF13945.6 ETO12415.1 - 0.89 9.6 46.6 0.35 10.9 15.1 3.3 3 1 0 3 3 3 0 Salt tolerance down-regulator Utp14 PF04615.13 ETO12415.1 - 1.2 7.6 27.5 1.6 7.2 27.5 1.1 1 0 0 1 1 1 0 Utp14 protein Lebercilin PF15619.6 ETO12416.1 - 0.023 14.4 15.8 0.23 11.1 12.2 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease NRBF2 PF08961.10 ETO12416.1 - 0.031 13.9 5.3 0.053 13.1 5.3 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Borrelia_REV PF03978.13 ETO12416.1 - 0.089 12.7 7.3 0.17 11.9 7.3 1.5 1 1 0 1 1 1 0 Borrelia burgdorferi REV protein APG6_N PF17675.1 ETO12416.1 - 0.63 10.6 11.6 1 9.9 11.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region ApoO PF09769.9 ETO12416.1 - 1.8 8.5 4.3 11 6.0 3.1 2.3 1 1 1 2 2 2 0 Apolipoprotein O FAM76 PF16046.5 ETO12416.1 - 2.6 7.3 11.5 3.3 7.0 11.5 1.1 1 0 0 1 1 1 0 FAM76 protein Seryl_tRNA_N PF02403.22 ETO12416.1 - 7.1 6.9 16.2 1.6 9.0 3.8 2.2 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF16 PF01519.16 ETO12416.1 - 8.5 6.9 14.4 4.4 7.9 10.9 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 Fib_alpha PF08702.10 ETO12417.1 - 0.014 15.6 21.0 0.015 15.5 19.5 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family APG17 PF04108.12 ETO12417.1 - 0.019 14.1 18.9 0.31 10.1 4.9 2.0 1 1 1 2 2 2 0 Autophagy protein Apg17 ERM PF00769.19 ETO12417.1 - 0.019 14.8 25.3 0.03 14.1 25.3 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family HMMR_N PF15905.5 ETO12417.1 - 0.039 13.4 27.1 0.06 12.8 27.1 1.2 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Atg14 PF10186.9 ETO12417.1 - 0.18 10.8 21.7 0.25 10.4 21.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FAM184 PF15665.5 ETO12417.1 - 0.29 10.9 22.7 0.41 10.4 22.7 1.2 1 0 0 1 1 1 0 Family with sequence similarity 184, A and B TPR_MLP1_2 PF07926.12 ETO12417.1 - 0.3 11.2 26.7 0.083 13.0 2.9 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc29 PF17082.5 ETO12417.1 - 0.3 10.9 15.5 0.32 10.8 9.2 2.2 1 1 1 2 2 2 0 Spindle Pole Component 29 DUF4618 PF15397.6 ETO12417.1 - 0.35 10.2 26.5 3.2 7.1 26.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) KxDL PF10241.9 ETO12417.1 - 0.4 11.0 26.1 0.69 10.2 4.4 2.5 1 1 1 2 2 2 0 Uncharacterized conserved protein CEP63 PF17045.5 ETO12417.1 - 0.52 10.2 27.3 1.3 8.8 10.9 2.0 1 1 1 2 2 2 0 Centrosomal protein of 63 kDa GAS PF13851.6 ETO12417.1 - 0.53 9.6 30.5 0.27 10.6 20.5 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding HOOK PF05622.12 ETO12417.1 - 0.97 7.5 29.8 1.8 6.6 29.8 1.4 1 1 0 1 1 1 0 HOOK protein Exonuc_VII_L PF02601.15 ETO12417.1 - 0.99 8.9 17.8 1.2 8.6 17.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ETO12417.1 - 1.3 8.3 19.2 1.8 7.8 19.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DLP_helical PF18709.1 ETO12417.1 - 1.4 8.1 19.4 1.8 7.7 2.4 2.1 1 1 1 2 2 2 0 Dynamin-like helical domain Prefoldin PF02996.17 ETO12417.1 - 1.5 8.8 20.7 0.096 12.6 3.2 3.1 2 1 1 3 3 3 0 Prefoldin subunit Synaptobrevin PF00957.21 ETO12417.1 - 2.3 8.1 10.5 0.4 10.5 6.3 1.9 1 1 1 2 2 2 0 Synaptobrevin COG2 PF06148.11 ETO12417.1 - 2.6 8.1 14.3 4.2 7.5 3.2 2.4 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Dna2 PF08696.11 ETO12417.1 - 3.4 7.4 10.0 0.92 9.3 1.2 2.1 2 0 0 2 2 2 0 DNA replication factor Dna2 BRE1 PF08647.11 ETO12417.1 - 3.8 7.6 27.9 19 5.4 16.9 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Pox_A_type_inc PF04508.12 ETO12417.1 - 8.6 6.4 9.5 0.88 9.5 0.4 3.6 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat Mod_r PF07200.13 ETO12417.1 - 8.6 6.5 27.0 0.82 9.8 8.8 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein HisKA_3 PF07730.13 ETO12417.1 - 9 6.9 13.1 2.5 8.7 0.1 3.3 1 1 2 3 3 3 0 Histidine kinase zf-CCHC PF00098.23 ETO12418.1 - 0.00015 21.6 7.3 0.0048 16.9 0.9 2.4 2 0 0 2 2 2 2 Zinc knuckle GFRP PF06399.13 ETO12418.1 - 0.077 12.9 0.0 0.17 11.8 0.0 1.5 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) zf-CCHC_3 PF13917.6 ETO12418.1 - 0.46 10.5 9.0 3.5 7.7 7.7 2.5 1 1 1 2 2 2 0 Zinc knuckle zf-CCHC_5 PF14787.6 ETO12418.1 - 3.5 7.4 10.5 1.7 8.4 2.5 2.6 1 1 1 2 2 2 0 GAG-polyprotein viral zinc-finger CIA30 PF08547.12 ETO12419.1 - 5.8e-16 58.9 0.0 1.1e-15 58.0 0.0 1.4 1 0 0 1 1 1 1 Complex I intermediate-associated protein 30 (CIA30) N6-adenineMlase PF10237.9 ETO12420.1 - 0.0058 16.4 0.2 0.011 15.6 0.1 1.4 1 1 0 1 1 1 1 Probable N6-adenine methyltransferase PDDEXK_7 PF04411.12 ETO12420.1 - 0.031 14.3 0.0 0.037 14.0 0.0 1.3 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily AP3D1 PF06375.11 ETO12421.1 - 0.0043 17.3 1.1 0.0043 17.3 1.1 1.9 2 0 0 2 2 2 1 AP-3 complex subunit delta-1 EMC3_TMCO1 PF01956.16 ETO12421.1 - 0.016 15.0 0.4 0.026 14.3 0.4 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Glyco_hydro_67N PF03648.14 ETO12421.1 - 0.035 14.4 0.3 0.062 13.6 0.3 1.5 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus NLRC4_HD PF17889.1 ETO12421.1 - 2.5 8.5 6.2 1.1 9.7 0.6 2.6 2 1 1 3 3 3 0 NLRC4 helical domain Biotin_carb_C PF02785.19 ETO12422.1 - 2e-34 117.9 0.0 2e-33 114.7 0.0 2.3 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain CPSase_L_D2 PF02786.17 ETO12422.1 - 3e-23 82.4 0.0 5.9e-23 81.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Holin_BhlA PF10960.8 ETO12423.1 - 0.94 9.5 0.0 0.94 9.5 0.0 4.1 3 2 0 3 3 3 0 BhlA holin family VIT1 PF01988.19 ETO12423.1 - 0.97 9.3 4.2 8.4 6.2 0.0 2.4 2 0 0 2 2 2 0 VIT family DUF1664 PF07889.12 ETO12423.1 - 1.3 9.1 18.5 0.81 9.7 2.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Ax_dynein_light PF10211.9 ETO12423.1 - 2.6 8.0 36.2 0.21 11.5 10.3 3.2 2 1 1 3 3 3 0 Axonemal dynein light chain Spc7 PF08317.11 ETO12423.1 - 3.5 6.4 35.3 5.7 5.7 18.0 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein APG6_N PF17675.1 ETO12423.1 - 7.9 7.0 35.9 20 5.7 17.2 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region Mt_ATP-synt_D PF05873.12 ETO12423.1 - 9.6 6.0 24.8 1.2 8.9 2.9 3.2 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) TPR_MLP1_2 PF07926.12 ETO12423.1 - 9.7 6.3 39.4 3.3 7.8 9.0 3.2 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Cid2 PF09774.9 ETO12424.1 - 0.97 9.8 8.6 2.1 8.7 8.6 1.6 1 0 0 1 1 1 0 Caffeine-induced death protein 2 DUF4200 PF13863.6 ETO12425.1 - 0.042 14.2 1.9 0.042 14.2 1.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Sas10_Utp3 PF04000.15 ETO12425.1 - 0.34 11.5 3.2 0.46 11.1 0.5 2.1 2 0 0 2 2 2 0 Sas10/Utp3/C1D family UPF0242 PF06785.11 ETO12425.1 - 3.6 7.7 8.3 5.3 7.1 8.3 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RRM_1 PF00076.22 ETO12426.1 - 0.0013 18.5 0.0 0.0022 17.8 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EZH2_WD-Binding PF11616.8 ETO12426.1 - 0.038 14.1 0.2 0.077 13.1 0.2 1.5 1 0 0 1 1 1 0 WD repeat binding protein EZH2 PPL5 PF18168.1 ETO12426.1 - 4.2 6.6 7.3 7.9 5.7 6.2 1.8 2 0 0 2 2 2 0 Prim-pol family 5 OST-HTH PF12872.7 ETO12427.1 - 0.00012 21.9 0.0 0.24 11.2 0.0 2.3 2 0 0 2 2 2 2 OST-HTH/LOTUS domain CNF1 PF05785.12 ETO12427.1 - 0.13 11.5 0.1 0.18 11.1 0.1 1.2 1 0 0 1 1 1 0 Rho-activating domain of cytotoxic necrotizing factor Mob1_phocein PF03637.17 ETO12429.1 - 1.2e-11 45.0 0.1 1.2e-11 45.0 0.1 2.7 3 0 0 3 3 3 1 Mob1/phocein family RIH_assoc PF08454.11 ETO12429.1 - 0.012 15.5 0.4 0.054 13.4 0.4 2.2 1 0 0 1 1 1 0 RyR and IP3R Homology associated RAP1 PF07218.11 ETO12430.1 - 0.35 9.1 4.2 0.5 8.6 4.2 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) SR-25 PF10500.9 ETO12430.1 - 2.1 7.9 5.8 4.5 6.8 5.8 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PRTase_2 PF15609.6 ETO12431.1 - 0.052 13.0 0.1 0.091 12.3 0.1 1.5 1 0 0 1 1 1 0 Phosphoribosyl transferase GTP_EFTU PF00009.27 ETO12432.1 - 2.1e-21 76.4 0.0 2.7e-21 76.0 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ETO12432.1 - 2.7e-06 27.5 0.1 0.0032 17.5 0.0 2.4 2 0 0 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 ETO12432.1 - 6e-05 23.1 0.1 0.00053 20.1 0.1 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO12432.1 - 0.0017 17.9 0.1 0.014 15.0 0.0 2.1 2 0 0 2 2 2 1 Ferrous iron transport protein B NOG1 PF06858.14 ETO12432.1 - 0.011 15.4 0.2 0.034 13.9 0.2 1.8 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) ZYG-11_interact PF05884.12 ETO12432.1 - 0.045 13.2 0.1 0.088 12.2 0.1 1.4 1 0 0 1 1 1 0 Interactor of ZYG-11 WD40 PF00400.32 ETO12435.1 - 2.9e-36 122.8 26.4 2.4e-08 34.5 0.4 7.5 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12435.1 - 3.7e-12 46.4 0.6 0.032 14.5 0.0 6.2 3 2 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12435.1 - 2.1e-08 33.3 2.7 2.7 6.5 0.0 5.9 3 2 2 6 6 6 5 Nucleoporin Nup120/160 NARP1 PF12569.8 ETO12435.1 - 5.7 5.7 10.8 8 5.2 10.8 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 eRF1_2 PF03464.15 ETO12436.1 - 1.2e-44 151.8 0.0 2.2e-44 151.0 0.0 1.4 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ETO12436.1 - 9.7e-31 106.6 0.1 2.7e-30 105.1 0.1 1.7 1 0 0 1 1 1 1 eRF1 domain 3 eRF1_1 PF03463.15 ETO12436.1 - 3.6e-19 69.0 0.0 5.8e-19 68.4 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 acVLRF1 PF18859.1 ETO12436.1 - 1.3e-08 35.2 0.0 2e-08 34.6 0.0 1.3 1 0 0 1 1 1 1 Actinobacteria/chloroflexi VLRF1 release factor baeRF_family10 PF18854.1 ETO12436.1 - 8.1e-08 32.6 0.0 1.4e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Bacterial archaeo-eukaryotic release factor family 10 Ribosomal_L7Ae PF01248.26 ETO12436.1 - 0.0013 18.5 0.0 0.0026 17.5 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family ATG13 PF10033.9 ETO12437.1 - 0.0015 18.3 0.5 0.0098 15.6 0.0 2.4 2 0 0 2 2 2 1 Autophagy-related protein 13 Ntox21 PF15526.6 ETO12437.1 - 3.7 7.9 6.6 28 5.1 1.7 2.5 2 0 0 2 2 2 0 Novel toxin 21 O-antigen_lig PF13425.6 ETO12439.1 - 0.00011 21.1 3.5 0.00015 20.8 3.5 1.0 1 0 0 1 1 1 1 O-antigen ligase like membrane protein FHA PF00498.26 ETO12439.1 - 0.047 14.0 0.0 0.098 13.0 0.0 1.5 1 0 0 1 1 1 0 FHA domain GBV-C_env PF12786.7 ETO12439.1 - 0.23 10.1 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 GB virus C genotype envelope ATAD4 PF15321.6 ETO12439.1 - 1.4 10.3 7.0 2.1 9.7 2.9 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 B56 PF01603.20 ETO12441.1 - 1.9e-25 89.7 0.3 2.3e-25 89.4 0.3 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RNase_3_N PF18497.1 ETO12441.1 - 0.1 12.8 0.1 0.93 9.7 0.0 2.1 2 0 0 2 2 2 0 Ribonuclease III N-terminal domain Urocanase_N PF17391.2 ETO12442.1 - 2.5e-20 72.5 0.0 3.5e-20 72.0 0.0 1.3 1 0 0 1 1 1 1 Urocanase N-terminal domain tRNA_lig_CPD PF08302.11 ETO12442.1 - 0.00046 19.7 0.4 0.00054 19.5 0.4 1.1 1 0 0 1 1 1 1 Fungal tRNA ligase phosphodiesterase domain ATP11 PF06644.11 ETO12442.1 - 0.0097 15.7 0.2 0.014 15.2 0.2 1.2 1 0 0 1 1 1 1 ATP11 protein DUF3641 PF12345.8 ETO12442.1 - 0.11 12.6 1.4 0.18 11.8 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3641) PPP5 PF08321.12 ETO12442.1 - 0.18 12.1 4.2 0.37 11.1 4.3 1.6 1 1 0 1 1 1 0 PPP5 TPR repeat region Urocanase_C PF17392.2 ETO12443.1 - 3.1e-85 284.6 0.6 2.1e-84 281.9 1.6 1.8 2 0 0 2 2 2 1 Urocanase C-terminal domain Urocanase PF01175.18 ETO12443.1 - 2.2e-56 190.8 0.7 1.6e-37 129.2 0.0 2.4 2 0 0 2 2 2 2 Urocanase Rossmann-like domain NAF PF03822.14 ETO12444.1 - 0.026 14.7 0.7 0.12 12.6 0.1 2.3 2 0 0 2 2 2 0 NAF domain PgdA_N PF18627.1 ETO12444.1 - 0.046 13.4 4.1 0.079 12.6 2.9 1.8 1 1 0 2 2 2 0 Peptidoglycan GlcNAc deacetylase N-terminal domain Tubulin PF00091.25 ETO12445.1 - 2.7e-68 230.1 0.0 5.2e-68 229.1 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO12445.1 - 4.2e-34 117.4 0.0 8.7e-34 116.4 0.0 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO12445.1 - 1.7e-05 25.1 0.0 4.6e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain DUF3801 PF12687.7 ETO12445.1 - 0.031 14.4 1.2 0.045 13.8 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3801) Tubulin_2 PF13809.6 ETO12445.1 - 0.095 11.9 0.1 0.3 10.2 0.0 1.8 2 0 0 2 2 2 0 Tubulin like Tubulin_3 PF14881.6 ETO12445.1 - 0.14 11.8 0.0 0.28 10.8 0.0 1.5 1 0 0 1 1 1 0 Tubulin domain L51_S25_CI-B8 PF05047.16 ETO12446.1 - 0.096 12.6 0.9 0.43 10.5 0.7 2.3 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L51 / S25 / CI-B8 domain Sfi1 PF08457.10 ETO12447.1 - 0.42 9.1 37.5 0.22 10.0 33.0 2.1 1 1 1 2 2 2 0 Sfi1 spindle body protein DUF1796 PF08795.10 ETO12449.1 - 0.072 13.1 0.1 0.36 10.8 0.0 2.2 2 0 0 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) SUI1 PF01253.22 ETO12449.1 - 0.22 12.0 1.3 1.7 9.2 0.0 2.9 3 0 0 3 3 3 0 Translation initiation factor SUI1 APG6_N PF17675.1 ETO12450.1 - 0.014 15.9 14.4 0.014 15.9 14.4 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region CENP-F_leu_zip PF10473.9 ETO12450.1 - 0.11 12.5 35.8 0.89 9.6 17.8 3.3 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO12450.1 - 0.3 9.9 40.3 0.23 10.3 20.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETO12450.1 - 0.34 11.0 19.2 1.5 8.9 5.0 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FapA PF03961.13 ETO12450.1 - 0.37 9.3 27.8 0.055 12.1 10.6 2.5 1 1 1 2 2 2 0 Flagellar Assembly Protein A ATG16 PF08614.11 ETO12450.1 - 0.51 10.5 42.7 0.23 11.7 18.1 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF3584 PF12128.8 ETO12450.1 - 7.3 4.0 35.9 39 1.6 35.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4164 PF13747.6 ETO12450.1 - 8.3 6.8 19.4 0.19 12.0 5.6 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) Arf PF00025.21 ETO12451.1 - 5.4e-42 143.2 0.0 6.5e-42 142.9 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO12451.1 - 9.8e-13 48.4 0.0 2e-12 47.4 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ETO12451.1 - 3.7e-11 42.8 1.2 1.3e-07 31.1 0.3 2.9 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ETO12451.1 - 1.5e-10 40.9 0.0 1.8e-10 40.6 0.0 1.1 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ETO12451.1 - 4.8e-10 39.5 0.0 6.9e-10 39.0 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO12451.1 - 2.5e-06 27.2 0.0 3.8e-05 23.3 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO12451.1 - 3e-06 26.8 0.0 3.7e-06 26.5 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ETO12451.1 - 0.00015 21.2 0.0 0.0002 20.9 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 ETO12451.1 - 0.17 11.7 0.1 4.7 6.9 0.0 2.1 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein PduV-EutP PF10662.9 ETO12451.1 - 0.18 11.6 0.1 1.2 8.8 0.1 2.2 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NOA36 PF06524.12 ETO12452.1 - 0.03 13.7 10.3 0.037 13.4 10.3 1.1 1 0 0 1 1 1 0 NOA36 protein NPR3 PF03666.13 ETO12452.1 - 0.086 11.6 10.6 0.093 11.5 10.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ETO12452.1 - 0.29 10.9 2.2 0.4 10.4 2.2 1.2 1 0 0 1 1 1 0 Connexin V_ATPase_I PF01496.19 ETO12452.1 - 0.29 9.0 4.8 0.35 8.7 4.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NST1 PF13945.6 ETO12452.1 - 0.52 10.4 22.0 0.81 9.8 22.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 ETO12452.1 - 0.92 8.2 8.6 0.95 8.2 8.6 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO12452.1 - 1 8.5 3.7 1.1 8.4 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO12452.1 - 1.6 8.7 4.3 1.8 8.6 4.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 ETO12452.1 - 1.9 7.5 3.1 2.4 7.1 3.1 1.1 1 0 0 1 1 1 0 CLN3 protein Serinc PF03348.15 ETO12452.1 - 2 7.2 4.4 2.7 6.8 4.4 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) MAP17 PF15807.5 ETO12452.1 - 6.6 7.0 7.5 9.6 6.5 7.5 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Clp1 PF06807.14 ETO12453.1 - 4e-11 43.3 0.0 7.8e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 CLP1_P PF16575.5 ETO12453.1 - 1.1e-06 28.5 0.5 5.9e-06 26.2 0.5 2.0 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop BAG6 PF12057.8 ETO12453.1 - 0.079 12.6 0.7 0.18 11.5 0.7 1.5 1 0 0 1 1 1 0 BCL2-associated athanogene 6 Y_phosphatase2 PF03162.13 ETO12454.1 - 5.9e-16 58.5 0.0 2.9e-14 53.0 0.0 2.4 2 0 0 2 2 2 2 Tyrosine phosphatase family Dzip-like_N PF13815.6 ETO12454.1 - 0.048 13.6 0.0 0.078 13.0 0.0 1.5 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal CRT-like PF08627.10 ETO12455.1 - 2.5e-07 30.0 1.7 2.9e-07 29.8 1.7 1.1 1 0 0 1 1 1 1 CRT-like, chloroquine-resistance transporter-like EamA PF00892.20 ETO12455.1 - 0.0019 18.4 8.0 0.0031 17.7 8.0 1.3 1 0 0 1 1 1 1 EamA-like transporter family PUNUT PF16913.5 ETO12455.1 - 0.0084 15.4 4.7 0.078 12.2 2.6 2.0 1 1 1 2 2 2 2 Purine nucleobase transmembrane transport MAT1 PF06391.13 ETO12456.1 - 0.34 10.7 19.1 4.3 7.1 15.5 2.7 2 0 0 2 2 2 0 CDK-activating kinase assembly factor MAT1 Ribophorin_I PF04597.14 ETO12457.1 - 1.8e-20 73.6 1.2 2.8e-20 72.9 1.2 1.3 1 0 0 1 1 1 1 Ribophorin I DUF3519 PF12033.8 ETO12457.1 - 0.87 10.0 4.9 5.4 7.5 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3519) CSRNP_N PF16019.5 ETO12460.1 - 1.1 9.1 3.6 1.5 8.7 3.6 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus NOA36 PF06524.12 ETO12460.1 - 7.8 5.7 7.9 10 5.4 7.9 1.1 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 ETO12461.1 - 0.27 10.6 15.7 0.4 10.1 15.7 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO12461.1 - 0.56 8.3 9.4 0.52 8.5 9.4 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO12461.1 - 0.57 8.4 7.5 0.71 8.1 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO12461.1 - 0.63 8.1 12.3 0.77 7.8 12.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ETO12462.1 - 3e-36 122.8 11.4 6.6e-12 45.8 0.4 5.6 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12462.1 - 9.4e-19 67.5 0.1 5e-05 23.5 0.0 3.8 1 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO12462.1 - 7.2e-07 29.3 0.0 0.00049 20.0 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO12462.1 - 1.1e-06 28.3 0.0 0.15 11.4 0.0 3.0 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO12462.1 - 1.1e-06 27.9 0.0 0.15 11.0 0.0 3.0 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO12462.1 - 6e-05 22.9 0.4 5 7.2 0.0 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO12462.1 - 0.00035 19.2 0.0 0.068 11.7 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO12462.1 - 0.0016 17.2 0.1 3.9 6.0 0.0 3.3 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO12462.1 - 0.0083 15.7 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 PQQ-like domain BLUF PF04940.12 ETO12462.1 - 0.0086 16.2 0.0 34 4.7 0.0 4.5 4 1 1 5 5 5 0 Sensors of blue-light using FAD RE_XamI PF09572.10 ETO12462.1 - 0.027 14.2 0.0 5.4 6.6 0.0 2.9 1 1 1 3 3 3 0 XamI restriction endonuclease DUF5570 PF17731.1 ETO12462.1 - 0.029 14.5 1.8 0.75 9.9 0.5 3.1 1 1 1 2 2 2 0 Family of unknown function (DUF5570) WXG100 PF06013.12 ETO12462.1 - 0.04 14.2 0.0 46 4.4 0.0 3.9 4 1 1 5 5 5 0 Proteins of 100 residues with WXG NYD-SP28_assoc PF14775.6 ETO12462.1 - 0.044 13.9 0.7 94 3.2 0.0 3.7 4 0 0 4 4 4 0 Sperm tail C-terminal domain Proteasome_A_N PF10584.9 ETO12462.1 - 0.048 13.3 4.5 12 5.6 0.1 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Germane PF10646.9 ETO12462.1 - 0.05 14.4 0.0 7.4 7.4 0.0 2.2 2 0 0 2 2 2 0 Sporulation and spore germination FCP1_C PF09309.10 ETO12462.1 - 0.051 13.4 0.0 22 4.8 0.0 3.3 1 1 3 4 4 4 0 FCP1, C-terminal Nbas_N PF15492.6 ETO12462.1 - 0.056 12.8 0.4 0.68 9.2 0.1 2.3 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF5604 PF18300.1 ETO12462.1 - 0.079 12.9 0.1 0.73 9.8 0.0 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF5604) ArlS_N PF18719.1 ETO12462.1 - 0.15 12.2 0.0 5.5 7.2 0.0 2.4 1 1 0 2 2 2 0 ArlS sensor domain YqaJ PF09588.10 ETO12463.1 - 0.091 12.9 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain AsnC_trans_reg2 PF17805.1 ETO12466.1 - 0.031 14.4 0.0 0.065 13.4 0.0 1.5 1 0 0 1 1 1 0 AsnC-like ligand binding domain DNA_pol_B_2 PF03175.13 ETO12468.1 - 1.2e-25 90.3 2.0 1.2e-25 90.3 2.0 2.1 3 0 0 3 3 3 1 DNA polymerase type B, organellar and viral DUF5530 PF17670.1 ETO12468.1 - 0.078 12.8 1.1 15 5.4 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5530) PI3_PI4_kinase PF00454.27 ETO12469.1 - 8.3e-45 153.5 0.5 3.8e-42 144.8 0.2 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETO12469.1 - 3e-32 111.5 5.2 3.5e-32 111.3 2.5 2.4 2 1 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ETO12469.1 - 0.047 13.0 0.0 0.53 9.6 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4135) Mucin PF01456.17 ETO12469.1 - 0.05 13.6 46.1 0.2 11.7 37.2 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2615 PF11027.8 ETO12469.1 - 3.1 8.0 5.5 0.3 11.2 0.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) AA_permease_2 PF13520.6 ETO12469.1 - 6.4 5.5 11.2 0.019 13.8 1.3 1.6 2 0 0 2 2 2 0 Amino acid permease WD40 PF00400.32 ETO12471.1 - 1.7e-40 136.2 32.0 2.4e-07 31.3 0.6 7.8 8 0 0 8 8 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12471.1 - 1e-15 57.7 2.3 0.0048 17.2 0.0 5.8 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12471.1 - 1.4e-11 43.8 12.7 0.0016 17.1 1.5 5.5 1 1 3 5 5 5 5 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO12471.1 - 1.9e-06 28.4 0.9 7.2e-06 26.6 0.9 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger WD40_like PF17005.5 ETO12471.1 - 5.8e-06 25.8 4.6 0.59 9.4 0.3 4.8 2 2 1 4 4 4 2 WD40-like domain HMMR_N PF15905.5 ETO12471.1 - 0.0053 16.3 45.5 0.011 15.2 45.5 1.5 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal UPF0242 PF06785.11 ETO12471.1 - 0.011 15.9 33.7 0.011 15.9 33.7 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spc7 PF08317.11 ETO12471.1 - 0.016 14.1 34.4 0.03 13.2 34.0 1.6 1 1 0 1 1 1 0 Spc7 kinetochore protein PDH PF02153.17 ETO12471.1 - 0.063 12.3 2.5 0.12 11.3 2.5 1.5 1 0 0 1 1 1 0 Prephenate dehydrogenase Kelch_6 PF13964.6 ETO12471.1 - 0.14 12.5 8.2 2.8 8.4 0.0 4.4 6 0 0 6 6 6 0 Kelch motif LemA PF04011.12 ETO12471.1 - 0.19 11.6 16.7 1.4 8.8 16.7 2.3 1 1 0 1 1 1 0 LemA family zf-C4H2 PF10146.9 ETO12471.1 - 0.52 10.6 22.5 1.2 9.4 22.5 1.6 1 0 0 1 1 1 0 Zinc finger-containing protein HrpB7 PF09486.10 ETO12471.1 - 4.4 7.7 11.1 16 5.8 11.1 1.9 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) FAM76 PF16046.5 ETO12471.1 - 4.4 6.6 36.6 5.3 6.3 30.5 3.2 2 1 0 2 2 2 0 FAM76 protein HEAT PF02985.22 ETO12474.1 - 0.0018 18.4 1.0 2.5 8.6 0.0 4.1 3 0 0 3 3 3 1 HEAT repeat Sigma70_ner PF04546.13 ETO12474.1 - 0.0024 17.8 7.7 0.1 12.5 0.1 3.1 3 0 0 3 3 3 2 Sigma-70, non-essential region RTTN_N PF14726.6 ETO12474.1 - 0.02 15.7 0.0 0.079 13.8 0.0 2.0 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning HNOB PF07700.15 ETO12474.1 - 0.024 14.6 0.0 0.17 11.9 0.0 2.2 2 0 0 2 2 2 0 Haem-NO-binding GlutR_dimer PF00745.20 ETO12474.1 - 0.026 15.0 0.3 0.33 11.4 0.1 2.6 2 1 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain HEAT_EZ PF13513.6 ETO12474.1 - 1.1 9.9 5.7 48 4.6 0.0 4.1 4 1 0 4 4 4 0 HEAT-like repeat Spt5_N PF11942.8 ETO12474.1 - 1.6 9.7 13.0 17 6.5 0.1 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.14 ETO12474.1 - 2.8 6.1 11.0 0.47 8.7 1.8 2.2 2 0 0 2 2 2 0 CDC45-like protein CDC45 PF02724.14 ETO12475.1 - 0.00051 18.5 19.3 0.00082 17.8 19.3 1.3 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO12475.1 - 0.0046 15.2 33.5 0.0078 14.5 33.5 1.4 1 0 0 1 1 1 1 Nop14-like family CobT PF06213.12 ETO12475.1 - 0.27 10.6 26.1 0.51 9.7 26.1 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_1B_p101 PF10486.9 ETO12475.1 - 9.6 3.8 14.7 18 2.9 14.7 1.5 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CALCOCO1 PF07888.11 ETO12476.1 - 0.00049 19.1 14.2 0.00057 18.9 14.2 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like ADIP PF11559.8 ETO12476.1 - 0.015 15.4 15.9 0.03 14.4 15.9 1.4 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Hema_stalk PF08720.10 ETO12476.1 - 0.035 13.8 1.3 0.046 13.4 1.3 1.2 1 0 0 1 1 1 0 Influenza C hemagglutinin stalk Fmp27_WPPW PF10359.9 ETO12476.1 - 0.052 12.4 12.7 0.065 12.1 12.7 1.1 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Tho2 PF11262.8 ETO12476.1 - 0.06 12.5 10.1 0.084 12.1 10.1 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Chrome_Resist PF09828.9 ETO12476.1 - 0.067 13.6 1.6 0.09 13.2 1.6 1.2 1 0 0 1 1 1 0 Chromate resistance exported protein V_ATPase_I PF01496.19 ETO12476.1 - 0.62 7.9 9.1 0.7 7.7 9.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ETO12476.1 - 1.1 7.9 3.4 1.3 7.7 3.4 1.1 1 0 0 1 1 1 0 Presenilin GCD14 PF08704.10 ETO12476.1 - 2.1 7.9 9.5 2.8 7.5 9.5 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit YabA PF06156.13 ETO12476.1 - 4.1 8.1 11.8 65 4.2 11.7 2.3 1 1 0 1 1 1 0 Initiation control protein YabA DUF3450 PF11932.8 ETO12476.1 - 4.1 6.6 23.2 0.59 9.4 12.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) FlxA PF14282.6 ETO12476.1 - 4.7 7.3 34.1 2.6 8.1 7.0 2.9 1 1 1 2 2 2 0 FlxA-like protein F-box PF00646.33 ETO12477.1 - 0.00034 20.4 0.0 0.00075 19.3 0.0 1.5 1 0 0 1 1 1 1 F-box domain Spc24 PF08286.11 ETO12477.1 - 0.13 12.5 7.4 2.8 8.2 1.1 2.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Prominin PF05478.11 ETO12477.1 - 0.54 8.2 5.9 0.8 7.6 5.9 1.2 1 0 0 1 1 1 0 Prominin FlaC_arch PF05377.11 ETO12477.1 - 0.64 10.4 5.2 11 6.5 0.4 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Tup_N PF08581.10 ETO12477.1 - 2.7 8.3 10.2 7.8 6.9 1.4 2.7 2 1 0 2 2 2 0 Tup N-terminal GrpE PF01025.19 ETO12477.1 - 4.1 7.0 14.3 1.5 8.5 1.3 2.7 2 1 0 3 3 3 0 GrpE ACCA PF03255.14 ETO12477.1 - 4.6 7.1 7.2 3.4 7.5 2.5 2.4 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CENP-I PF07778.11 ETO12478.1 - 1.1 7.9 3.8 1.1 7.9 3.8 1.0 1 0 0 1 1 1 0 Mis6 ArsB PF02040.15 ETO12479.1 - 5.3e-10 39.2 4.8 6.3e-10 38.9 4.8 1.0 1 0 0 1 1 1 1 Arsenical pump membrane protein CitMHS PF03600.16 ETO12479.1 - 0.00011 21.5 3.9 0.00011 21.5 3.9 1.8 1 1 1 2 2 2 2 Citrate transporter CIDE-N PF02017.15 ETO12479.1 - 0.081 13.0 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 CIDE-N domain OmpH PF03938.14 ETO12480.1 - 0.68 10.3 15.8 0.26 11.6 13.5 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4337 PF14235.6 ETO12480.1 - 1.8 8.7 13.4 2 8.5 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) NEMP PF10225.9 ETO12480.1 - 4.3 6.9 5.9 4.6 6.8 5.9 1.1 1 0 0 1 1 1 0 NEMP family 4HB_MCP_1 PF12729.7 ETO12480.1 - 5.2 6.6 14.2 5.9 6.4 14.2 1.0 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction MCM PF00493.23 ETO12481.1 - 2.2e-36 125.0 0.2 3.5e-36 124.4 0.2 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_lid PF17855.1 ETO12481.1 - 1.9e-28 98.7 0.4 1.2e-26 92.9 0.1 2.4 2 0 0 2 2 2 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ETO12481.1 - 0.018 14.4 0.7 0.039 13.3 0.1 1.9 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_lid_2 PF17863.1 ETO12481.1 - 0.029 14.2 0.1 0.081 12.8 0.1 1.8 1 0 0 1 1 1 0 AAA lid domain PEP-utilisers_N PF05524.13 ETO12482.1 - 1.5 9.1 10.4 1.1 9.4 2.7 3.4 3 0 0 3 3 3 0 PEP-utilising enzyme, N-terminal YccF PF03733.13 ETO12483.1 - 5.7e-05 23.7 10.3 5.7e-05 23.7 10.3 2.4 2 0 0 2 2 2 1 Inner membrane component domain L-fibroin PF05849.11 ETO12483.1 - 0.061 12.6 0.0 0.083 12.2 0.0 1.1 1 0 0 1 1 1 0 Fibroin light chain (L-fibroin) MRAP PF15183.6 ETO12483.1 - 0.096 12.6 0.1 0.22 11.5 0.1 1.7 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family Pox_A9 PF04835.12 ETO12483.1 - 7.1 6.9 7.8 4 7.7 2.4 2.4 2 0 0 2 2 2 0 A9 protein conserved region 7TM_GPCR_Sru PF10322.9 ETO12484.1 - 0.045 13.1 2.2 1.5 8.0 0.3 2.1 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru PDR_CDR PF06422.12 ETO12484.1 - 0.058 13.3 0.4 0.56 10.2 0.3 2.3 2 0 0 2 2 2 0 CDR ABC transporter Gly-zipper_YMGG PF13441.6 ETO12485.1 - 0.001 18.8 0.0 0.0026 17.4 0.0 1.7 1 1 0 1 1 1 1 YMGG-like Gly-zipper DivIVA PF05103.13 ETO12485.1 - 0.009 16.1 6.6 0.009 16.1 6.6 2.8 3 0 0 3 3 3 1 DivIVA protein MiaE PF06175.11 ETO12485.1 - 0.016 14.8 0.1 0.016 14.8 0.1 2.5 3 0 0 3 3 3 0 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) T2SSS_2 PF16549.5 ETO12485.1 - 0.018 15.0 2.9 0.79 9.8 0.1 3.5 3 0 0 3 3 3 0 Type II secretion system (T2SS) pilotin, S protein DUF4349 PF14257.6 ETO12485.1 - 0.18 11.3 2.9 0.2 11.1 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Gly-zipper_Omp PF13488.6 ETO12485.1 - 0.42 10.7 6.8 4.1 7.5 1.4 2.3 2 0 0 2 2 2 0 Glycine zipper HSBP1 PF06825.12 ETO12485.1 - 5.5 6.9 7.1 0.72 9.8 0.7 2.8 2 1 1 3 3 3 0 Heat shock factor binding protein 1 NPV_P10 PF05531.12 ETO12485.1 - 5.8 7.5 15.7 27 5.3 11.2 3.4 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 ETO12485.1 - 8.9 6.7 13.0 49 4.3 6.6 3.7 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Slu7 PF11708.8 ETO12486.1 - 1e-19 71.4 26.0 1e-19 71.4 26.0 2.8 2 1 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor DUF755 PF05501.11 ETO12486.1 - 1.5 9.1 19.7 0.66 10.2 12.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF755) ANAPC15 PF15243.6 ETO12486.1 - 1.8 9.0 13.6 4.5 7.7 13.6 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 DUF913 PF06025.12 ETO12486.1 - 2.2 7.2 5.5 0.86 8.5 2.4 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 ETO12486.1 - 4.8 6.5 15.4 15 4.8 10.3 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4746) CSRNP_N PF16019.5 ETO12486.1 - 5.5 6.8 16.9 9.8 6.0 13.4 2.5 2 1 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus DUF2201_N PF13203.6 ETO12486.1 - 5.7 6.5 9.1 1.4 8.4 6.0 1.6 2 0 0 2 2 2 0 Putative metallopeptidase domain MCU PF04678.13 ETO12486.1 - 7.5 6.6 7.5 1.1 9.3 3.4 1.7 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DUF2076 PF09849.9 ETO12486.1 - 9.9 6.1 14.9 3.3 7.7 12.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) RhoGAP PF00620.27 ETO12487.1 - 9.4e-19 67.7 0.0 2.4e-18 66.4 0.0 1.7 1 0 0 1 1 1 1 RhoGAP domain Peptidase_C14 PF00656.22 ETO12488.1 - 2e-13 50.9 3.1 2e-13 50.9 1.8 1.6 1 1 0 1 1 1 1 Caspase domain Imm32 PF15566.6 ETO12488.1 - 0.12 12.1 1.8 0.19 11.6 0.1 2.2 2 0 0 2 2 2 0 Immunity protein 32 GP41 PF00517.17 ETO12488.1 - 1 9.2 8.6 0.17 11.8 3.0 2.1 2 0 0 2 2 2 0 Retroviral envelope protein TPR_12 PF13424.6 ETO12489.1 - 8e-40 135.0 8.2 1.5e-22 79.6 0.5 2.9 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12489.1 - 1.1e-30 104.2 22.8 8.9e-11 41.1 2.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12489.1 - 3e-30 102.0 2.7 7e-10 38.2 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12489.1 - 1.8e-28 97.5 8.0 3.4e-11 42.6 0.0 4.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12489.1 - 8.6e-26 87.9 18.8 1.8e-08 33.9 0.9 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12489.1 - 1e-23 81.5 22.8 5.6e-10 38.6 1.3 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12489.1 - 3.8e-13 49.9 0.0 0.0066 17.1 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO12489.1 - 2.2e-12 46.8 3.9 0.0024 18.4 0.5 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12489.1 - 4e-11 42.8 0.0 0.03 15.1 0.0 3.4 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12489.1 - 6e-11 41.9 13.0 0.00067 19.9 0.0 4.6 6 1 0 6 6 3 3 Tetratricopeptide repeat TPR_3 PF07720.12 ETO12489.1 - 1.3e-08 34.6 15.2 0.056 13.5 2.5 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO12489.1 - 3e-08 33.2 26.6 0.00045 19.8 0.7 5.9 4 2 2 6 6 6 3 TPR repeat PPR PF01535.20 ETO12489.1 - 3.3e-08 33.2 5.9 0.01 16.1 0.1 4.1 4 0 0 4 4 4 2 PPR repeat SNAP PF14938.6 ETO12489.1 - 6.7e-08 32.3 5.1 9.1e-05 22.0 0.8 2.1 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO12489.1 - 6.5e-06 26.0 9.1 0.11 12.3 0.2 3.2 2 1 1 3 3 3 2 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO12489.1 - 1.5e-05 25.4 0.5 0.071 13.6 0.1 3.5 1 1 2 3 3 3 2 Tetratricopeptide repeat RPN7 PF10602.9 ETO12489.1 - 4.8e-05 23.1 6.3 0.14 11.8 0.2 3.1 1 1 2 3 3 3 2 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ETO12489.1 - 6.7e-05 22.4 0.0 0.00012 21.6 0.0 1.4 1 1 0 1 1 1 1 MalT-like TPR region MIT PF04212.18 ETO12489.1 - 0.00021 21.3 14.5 0.17 12.0 0.5 3.6 4 0 0 4 4 3 2 MIT (microtubule interacting and transport) domain ATP-synt_E_2 PF08112.11 ETO12489.1 - 0.0003 21.0 5.5 0.31 11.3 1.2 2.8 2 0 0 2 2 2 2 ATP synthase epsilon subunit SHNi-TPR PF10516.9 ETO12489.1 - 0.00049 19.5 1.0 3 7.4 0.0 3.5 3 0 0 3 3 3 1 SHNi-TPR ANAPC3 PF12895.7 ETO12489.1 - 0.00084 19.5 10.7 0.18 12.0 1.4 3.5 1 1 3 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 Mob_Pre PF01076.19 ETO12489.1 - 0.00084 19.2 0.8 0.00084 19.2 0.8 1.8 1 1 1 2 2 2 1 Plasmid recombination enzyme Fis1_TPR_C PF14853.6 ETO12489.1 - 0.0009 19.3 13.7 0.009 16.1 2.0 3.4 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat DUF2225 PF09986.9 ETO12489.1 - 0.0022 17.7 6.4 0.41 10.3 0.2 2.4 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) DUF4810 PF16068.5 ETO12489.1 - 0.003 18.1 2.3 6.1 7.5 0.1 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) Clathrin PF00637.20 ETO12489.1 - 0.0039 17.1 4.0 7.2 6.5 0.1 3.4 2 1 1 3 3 3 0 Region in Clathrin and VPS DUF627 PF04781.12 ETO12489.1 - 0.0096 15.9 5.0 4.9 7.2 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF627) TPR_9 PF13371.6 ETO12489.1 - 0.01 16.0 0.0 2.3 8.4 0.0 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO12489.1 - 0.016 15.9 13.5 6.2 7.7 0.4 5.0 4 3 0 4 4 4 0 Sel1 repeat SPO22 PF08631.10 ETO12489.1 - 0.018 14.6 6.4 2.2 7.7 0.2 3.2 2 2 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like Mad3_BUB1_I PF08311.12 ETO12489.1 - 0.022 14.7 8.4 0.64 10.0 0.1 3.1 2 1 1 3 3 3 0 Mad3/BUB1 homology region 1 PPR_2 PF13041.6 ETO12489.1 - 0.028 14.6 5.4 13 6.1 0.1 3.9 4 0 0 4 4 4 0 PPR repeat family UPF0223 PF05256.12 ETO12489.1 - 0.036 14.4 3.8 0.86 10.0 0.1 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0223) DUF357 PF04010.13 ETO12489.1 - 0.045 13.8 6.8 2.1 8.4 0.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF357) OrfA PF17495.2 ETO12489.1 - 0.11 12.7 0.0 19 5.5 0.0 2.4 1 1 2 3 3 3 0 Vpr-like OrfA TetR_C_19 PF17924.1 ETO12489.1 - 0.31 11.6 4.2 11 6.7 0.1 3.0 3 1 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain DUF3450 PF11932.8 ETO12489.1 - 1.4 8.2 5.5 9.6 5.4 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Metallophos PF00149.28 ETO12490.1 - 6.6e-14 52.9 2.6 1.2e-13 52.0 2.6 1.5 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ETO12490.1 - 8.6e-11 42.3 0.0 3.4e-10 40.4 0.0 2.1 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3_PAP PF17808.1 ETO12490.1 - 4.8e-09 36.4 0.7 1.5e-08 34.8 0.7 1.8 1 1 0 1 1 1 1 Fn3-like domain from Purple Acid Phosphatase Metallophos_C PF14008.6 ETO12490.1 - 1.1e-08 35.7 2.9 1.6e-08 35.3 0.3 2.7 2 0 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C zf-RING_UBOX PF13445.6 ETO12491.1 - 2.9e-09 36.8 10.1 1.6e-08 34.4 5.6 2.7 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO12491.1 - 1.9e-06 28.1 13.2 5.1e-06 26.7 6.2 2.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ETO12491.1 - 1.9e-06 27.6 13.5 4.3e-05 23.3 13.5 2.6 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO12491.1 - 7.6e-06 25.7 12.1 0.00038 20.2 5.6 2.6 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO12491.1 - 2.1e-05 24.4 13.8 0.00014 21.8 13.8 2.3 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETO12491.1 - 2.9e-05 23.8 6.0 2.9e-05 23.8 6.0 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO12491.1 - 3.3e-05 23.5 8.2 9.8e-05 22.0 8.2 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_4 PF15227.6 ETO12491.1 - 0.0031 17.6 7.2 0.0031 17.6 7.2 2.9 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ETO12491.1 - 0.0033 17.3 1.4 0.0092 15.8 1.4 1.8 1 0 0 1 1 1 1 zf-RING of BARD1-type protein Scytalone_dh PF02982.14 ETO12491.1 - 0.0069 16.2 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 Scytalone dehydratase zf-rbx1 PF12678.7 ETO12491.1 - 0.0099 16.1 7.3 0.081 13.2 2.8 3.0 2 0 0 2 2 2 1 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ETO12491.1 - 0.017 15.0 12.4 0.49 10.3 6.2 2.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETO12491.1 - 0.052 13.6 9.6 1.1 9.4 1.4 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_4 PF14570.6 ETO12491.1 - 1.3 8.9 11.9 5.5 6.9 0.3 2.9 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain 3HCDH_N PF02737.18 ETO12491.1 - 1.9 8.3 5.9 0.58 10.0 0.3 2.8 2 2 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Rad50_zn_hook PF04423.14 ETO12491.1 - 3.6 7.5 13.0 0.48 10.3 2.8 3.8 3 1 0 3 3 3 0 Rad50 zinc hook motif RRM_Rrp7 PF17799.1 ETO12491.1 - 5 6.9 13.3 0.047 13.5 2.2 2.7 2 1 0 2 2 2 0 Rrp7 RRM-like N-terminal domain Glyco_hydro_99 PF16317.5 ETO12492.1 - 3.3e-90 302.7 19.1 7.3e-90 301.5 19.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 99 Glyco_tran_WbsX PF14307.6 ETO12492.1 - 4.3e-05 23.1 1.9 4.3e-05 23.1 1.9 2.8 2 1 0 2 2 2 1 Glycosyltransferase WbsX Pinin_SDK_memA PF04696.13 ETO12492.1 - 0.061 13.4 4.2 0.14 12.2 4.2 1.5 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF2681 PF10883.8 ETO12492.1 - 0.1 13.0 2.4 0.29 11.6 2.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) WD40 PF00400.32 ETO12493.1 - 3.5e-61 201.7 18.9 6.1e-09 36.4 0.6 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12493.1 - 1.8e-23 82.6 0.3 0.00019 21.6 0.0 6.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12493.1 - 2.8e-13 49.5 0.5 0.19 10.6 0.0 6.7 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12493.1 - 4.1e-09 36.2 1.0 0.041 13.2 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO12493.1 - 0.00018 20.3 2.3 0.18 10.4 0.0 4.1 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO12493.1 - 0.00074 19.6 0.7 6.8 6.9 0.0 4.4 4 1 1 5 5 4 1 Strictosidine synthase Nbas_N PF15492.6 ETO12493.1 - 0.0015 17.9 1.1 1 8.7 0.0 3.4 2 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO12493.1 - 0.002 18.2 1.7 16 5.6 0.0 4.3 3 1 1 4 4 4 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO12493.1 - 0.0033 16.0 3.2 0.32 9.5 0.1 3.1 4 0 0 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO12493.1 - 0.0051 16.7 1.8 7.8 6.6 0.1 4.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat TBP PF00352.21 ETO12493.1 - 0.0091 15.9 0.0 0.04 13.9 0.0 2.1 2 0 0 2 2 2 1 Transcription factor TFIID (or TATA-binding protein, TBP) Utp8 PF10395.9 ETO12493.1 - 0.015 13.8 0.1 0.63 8.5 0.0 2.1 2 0 0 2 2 2 0 Utp8 family PQQ_2 PF13360.6 ETO12493.1 - 0.03 13.9 0.0 0.36 10.4 0.0 2.3 2 1 0 2 2 2 0 PQQ-like domain DPPIV_N PF00930.21 ETO12493.1 - 0.036 12.8 0.0 4.4 6.0 0.0 3.6 2 1 3 5 5 5 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Fapy_DNA_glyco PF01149.24 ETO12493.1 - 0.14 12.7 0.0 0.29 11.8 0.0 1.5 1 0 0 1 1 1 0 Formamidopyrimidine-DNA glycosylase N-terminal domain Proteasome_A_N PF10584.9 ETO12493.1 - 1 9.1 9.9 38 4.1 0.2 5.7 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Voltage_CLC PF00654.20 ETO12494.1 - 4.1e-40 138.1 19.0 8.3e-23 81.2 2.4 2.0 1 1 1 2 2 2 2 Voltage gated chloride channel G-alpha PF00503.20 ETO12496.1 - 1.4e-95 320.5 10.3 1.7e-95 320.2 10.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO12496.1 - 3.6e-14 52.6 2.3 1e-10 41.3 0.5 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO12496.1 - 0.0037 17.5 2.9 0.87 9.8 0.3 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ETO12496.1 - 0.01 15.2 4.1 0.034 13.5 0.3 2.5 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO12496.1 - 0.014 15.5 0.4 2.2 8.4 0.4 2.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO12496.1 - 0.027 14.0 0.5 5.1 6.6 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_24 PF13479.6 ETO12496.1 - 0.04 13.6 0.6 0.23 11.1 0.1 2.3 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO12496.1 - 0.11 12.9 0.0 0.18 12.2 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ETO12496.1 - 0.16 11.7 0.1 0.36 10.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 ETO12497.1 - 1.6e-31 109.5 0.0 3.9e-31 108.2 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO12497.1 - 3.3e-11 42.8 0.1 1e-10 41.3 0.0 1.9 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 ETO12497.1 - 0.00048 20.1 0.0 0.034 14.2 0.0 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO12497.1 - 0.0005 20.3 0.0 0.002 18.4 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO12497.1 - 0.005 17.2 0.1 0.055 13.9 0.0 2.2 1 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 ETO12497.1 - 0.0051 17.0 0.2 0.059 13.5 0.0 2.6 3 1 0 3 3 3 1 AAA domain AAA_7 PF12775.7 ETO12497.1 - 0.0065 16.0 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region Vps4_C PF09336.10 ETO12497.1 - 0.0079 16.2 0.0 0.021 14.8 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain NACHT PF05729.12 ETO12497.1 - 0.011 15.7 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ETO12497.1 - 0.028 14.8 1.6 0.36 11.3 0.0 3.2 3 0 0 3 3 3 0 RNA helicase DUF1517 PF07466.11 ETO12497.1 - 0.029 14.5 1.0 0.058 13.5 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1517) RuvB_N PF05496.12 ETO12497.1 - 0.043 13.6 0.0 0.19 11.4 0.0 2.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ETO12497.1 - 0.044 13.9 0.0 0.15 12.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ETO12497.1 - 0.059 13.9 1.2 0.13 12.8 0.2 2.3 2 1 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ETO12497.1 - 0.067 12.6 0.3 0.15 11.4 0.1 1.6 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO12497.1 - 0.12 12.1 0.0 0.34 10.6 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_17 PF13207.6 ETO12497.1 - 0.12 12.8 0.6 0.32 11.4 0.0 2.0 2 0 0 2 2 1 0 AAA domain Hydin_ADK PF17213.3 ETO12497.1 - 0.27 11.5 4.2 6.8 6.9 2.9 2.6 2 1 0 2 2 2 0 Hydin Adenylate kinase-like domain DUF3829 PF12889.7 ETO12498.1 - 0.0035 16.9 3.0 0.0051 16.3 3.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3829) AAA_6 PF12774.7 ETO12498.1 - 0.013 14.5 0.1 0.027 13.5 0.1 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region E2F_CC-MB PF16421.5 ETO12498.1 - 0.051 13.9 1.0 0.11 12.9 1.0 1.6 1 0 0 1 1 1 0 E2F transcription factor CC-MB domain Spc7 PF08317.11 ETO12498.1 - 0.057 12.3 7.3 0.079 11.8 7.3 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 ETO12498.1 - 0.058 13.4 2.7 0.093 12.8 2.7 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4320 PF14208.6 ETO12498.1 - 0.06 13.4 0.6 0.12 12.5 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) Exonuc_VII_L PF02601.15 ETO12498.1 - 0.062 12.9 2.1 0.077 12.6 2.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4349 PF14257.6 ETO12498.1 - 0.066 12.7 2.7 0.094 12.2 2.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) APG6_N PF17675.1 ETO12498.1 - 0.11 13.0 5.1 0.19 12.2 5.1 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region LprI PF07007.12 ETO12498.1 - 0.14 12.9 0.9 2.9 8.6 0.3 2.3 2 0 0 2 2 2 0 Lysozyme inhibitor LprI Fib_alpha PF08702.10 ETO12498.1 - 0.34 11.1 8.3 0.7 10.1 5.8 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family BST2 PF16716.5 ETO12498.1 - 0.9 10.2 6.6 2.2 8.9 5.1 2.0 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Snapin_Pallidin PF14712.6 ETO12498.1 - 1.1 9.8 7.5 0.76 10.2 3.7 2.2 1 1 1 2 2 2 0 Snapin/Pallidin NPV_P10 PF05531.12 ETO12498.1 - 1.1 9.7 6.8 42 4.7 6.8 2.6 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.22 ETO12498.1 - 1.4 9.2 8.9 7.7 6.8 8.6 2.2 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 ETO12498.1 - 1.7 9.1 6.8 10 6.6 2.2 2.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ETO12498.1 - 2.3 8.3 6.8 7.6 6.6 6.7 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) PMP22_Claudin PF00822.20 ETO12499.1 - 0.024 14.5 0.6 0.027 14.4 0.6 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family Peptidase_C14 PF00656.22 ETO12499.1 - 0.054 13.4 0.1 0.067 13.1 0.1 1.2 1 0 0 1 1 1 0 Caspase domain DUF3172 PF11371.8 ETO12500.1 - 0.076 12.7 0.1 0.18 11.5 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3172) ARL2_Bind_BART PF11527.8 ETO12501.1 - 0.03 14.4 3.3 0.055 13.6 3.3 1.5 1 1 0 1 1 1 0 The ARF-like 2 binding protein BART DUF3399 PF11879.8 ETO12501.1 - 0.057 13.7 0.2 0.076 13.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3399) UQ_con PF00179.26 ETO12503.1 - 5.5e-28 97.4 0.0 5.5e-28 97.4 0.0 2.0 2 0 0 2 2 1 1 Ubiquitin-conjugating enzyme U-box PF04564.15 ETO12503.1 - 1.5e-11 44.3 0.1 1.7e-09 37.7 0.0 2.7 2 0 0 2 2 2 1 U-box domain ubiquitin PF00240.23 ETO12503.1 - 3e-11 42.9 0.0 3e-11 42.9 0.0 2.1 2 0 0 2 2 1 1 Ubiquitin family TFIIA PF03153.13 ETO12503.1 - 0.00049 20.2 25.6 0.001 19.2 25.6 1.5 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-Nse PF11789.8 ETO12503.1 - 0.00091 19.0 0.1 0.89 9.4 0.1 3.6 3 0 0 3 3 3 1 Zinc-finger of the MIZ type in Nse subunit VWA_2 PF13519.6 ETO12503.1 - 0.0012 19.5 1.6 0.41 11.3 0.0 3.6 3 1 0 3 3 2 1 von Willebrand factor type A domain TraV PF09676.10 ETO12503.1 - 0.019 15.9 14.7 0.019 15.9 14.7 3.2 3 0 0 3 3 2 0 Type IV conjugative transfer system lipoprotein (TraV) zf-NOSIP PF15906.5 ETO12503.1 - 0.024 14.8 0.0 0.42 10.8 0.0 2.7 2 0 0 2 2 2 0 Zinc-finger of nitric oxide synthase-interacting protein Suf PF05843.14 ETO12503.1 - 0.04 13.9 18.4 0.12 12.4 18.4 1.8 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) SDA1 PF05285.12 ETO12503.1 - 0.051 13.0 32.3 0.08 12.4 25.9 2.5 2 0 0 2 2 2 0 SDA1 Zip PF02535.22 ETO12503.1 - 0.17 11.0 10.3 0.31 10.2 10.3 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Hid1 PF12722.7 ETO12503.1 - 0.23 9.5 22.1 0.43 8.6 22.1 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein GREB1 PF15782.5 ETO12503.1 - 0.26 8.4 18.8 0.4 7.8 18.8 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 ETO12503.1 - 0.3 11.1 16.1 0.15 12.1 12.2 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Mem_trans PF03547.18 ETO12503.1 - 0.39 9.1 0.9 0.53 8.6 0.9 1.3 1 0 0 1 1 1 0 Membrane transport protein Ndc1_Nup PF09531.10 ETO12503.1 - 0.44 9.2 14.2 0.73 8.4 14.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RR_TM4-6 PF06459.12 ETO12503.1 - 0.57 10.0 29.8 0.042 13.7 22.9 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PAT1 PF09770.9 ETO12503.1 - 0.59 8.3 27.4 0.92 7.7 27.4 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Rtf2 PF04641.12 ETO12503.1 - 0.85 8.9 0.0 0.85 8.9 0.0 3.7 2 1 1 3 3 2 0 Rtf2 RING-finger DUF572 PF04502.13 ETO12503.1 - 1.1 8.8 32.4 0.34 10.5 26.6 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF572) SID-1_RNA_chan PF13965.6 ETO12503.1 - 1.2 7.4 5.9 2.1 6.7 5.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Nop53 PF07767.11 ETO12503.1 - 1.3 8.3 46.0 0.018 14.4 32.0 2.8 3 0 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) DUF2370 PF10176.9 ETO12503.1 - 3.8 7.1 7.8 8.7 5.9 7.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) SLC12 PF03522.15 ETO12503.1 - 4.8 6.1 29.5 0.43 9.5 24.4 1.7 2 0 0 2 2 2 0 Solute carrier family 12 DUF2052 PF09747.9 ETO12503.1 - 6.6 6.8 29.9 0.61 10.2 19.9 3.1 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) RhoGEF PF00621.20 ETO12504.1 - 9.7e-12 45.5 0.4 1.2e-11 45.2 0.4 1.1 1 0 0 1 1 1 1 RhoGEF domain Pkinase PF00069.25 ETO12506.1 - 2.7e-57 194.2 2.3 1.2e-43 149.4 2.0 3.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12506.1 - 1.1e-27 96.9 1.0 1.7e-16 60.3 0.2 3.2 2 1 1 3 3 3 3 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO12506.1 - 6.3e-08 32.0 1.5 6.3e-08 32.0 1.5 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ETO12506.1 - 0.00083 18.8 0.4 0.0015 17.9 0.4 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO12506.1 - 0.014 14.7 0.1 0.037 13.3 0.0 1.7 3 0 0 3 3 3 0 Kinase-like FTA2 PF13095.6 ETO12506.1 - 0.022 14.4 0.2 0.11 12.1 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DNA_pol_phi PF04931.13 ETO12506.1 - 0.062 11.4 2.1 0.11 10.6 2.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 ETO12506.1 - 0.25 11.1 2.6 0.59 9.9 2.6 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Secretin_N_2 PF07655.13 ETO12506.1 - 2.2 8.9 15.4 3.1 8.4 6.4 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain HEAT PF02985.22 ETO12507.1 - 2.5e-08 33.5 0.2 0.027 14.7 0.0 3.7 4 0 0 4 4 3 2 HEAT repeat Ank_3 PF13606.6 ETO12507.1 - 2.6e-08 33.5 0.1 0.00069 19.9 0.0 3.3 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ETO12507.1 - 2.8e-06 27.8 0.1 1.1e-05 25.9 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO12507.1 - 2.6e-05 24.4 0.1 8.2e-05 22.8 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HEAT_2 PF13646.6 ETO12507.1 - 3.6e-05 24.1 0.0 0.00012 22.4 0.0 1.9 1 1 1 2 2 2 2 HEAT repeats RTP1_C1 PF10363.9 ETO12507.1 - 9.5e-05 22.6 1.1 0.011 15.9 0.0 3.3 2 1 1 3 3 3 1 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETO12507.1 - 0.00066 19.8 3.5 0.0011 19.0 1.2 2.6 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Ank_4 PF13637.6 ETO12507.1 - 0.0014 19.2 0.2 0.0068 17.0 0.2 2.3 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO12507.1 - 0.0043 17.4 0.0 0.023 15.1 0.0 2.3 1 0 0 1 1 1 1 Ankyrin repeat DNA_meth_N PF18284.1 ETO12507.1 - 0.016 15.1 0.2 5.5 7.0 0.1 2.6 2 0 0 2 2 2 0 DNA methylase N-terminal domain DUF4497 PF14924.6 ETO12507.1 - 0.089 13.3 0.0 0.29 11.6 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF4497) HEAT_EZ PF13513.6 ETO12507.1 - 0.099 13.2 0.0 17 6.0 0.0 3.0 3 0 0 3 3 3 0 HEAT-like repeat Annexin PF00191.20 ETO12507.1 - 0.11 12.6 0.0 21 5.3 0.0 3.0 2 0 0 2 2 2 0 Annexin PH_18 PF18469.1 ETO12507.1 - 0.12 12.3 2.7 1.6 8.7 1.6 2.7 2 0 0 2 2 2 0 Pleckstrin homology domain HEAT PF02985.22 ETO12508.1 - 4.3e-05 23.4 0.0 2.6 8.5 0.0 4.3 3 0 0 3 3 3 2 HEAT repeat CLASP_N PF12348.8 ETO12508.1 - 0.0011 18.5 3.3 0.0017 18.0 0.1 2.7 3 1 1 4 4 4 1 CLASP N terminal THDPS_N PF14790.6 ETO12508.1 - 0.015 15.1 2.7 0.021 14.7 1.3 2.0 2 0 0 2 2 2 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal MMS19_N PF14500.6 ETO12508.1 - 0.022 14.4 2.3 0.49 9.9 0.1 3.1 2 2 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II SelP_N PF04592.14 ETO12509.1 - 0.0049 16.3 7.0 0.0064 15.9 7.0 1.1 1 0 0 1 1 1 1 Selenoprotein P, N terminal region CLTH PF10607.9 ETO12511.1 - 4.8e-09 36.3 3.9 4.8e-09 36.3 3.9 1.9 2 0 0 2 2 2 1 CTLH/CRA C-terminal to LisH motif domain Apt1 PF10351.9 ETO12512.1 - 0.0037 16.2 9.3 0.0082 15.0 9.3 1.5 1 0 0 1 1 1 1 Golgi-body localisation protein domain zf-met PF12874.7 ETO12512.1 - 0.016 15.6 11.8 5.2 7.6 1.6 4.1 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ETO12512.1 - 0.026 14.8 0.4 0.026 14.8 0.4 4.4 4 1 0 4 4 4 0 Zinc-finger double-stranded RNA-binding RRM_1 PF00076.22 ETO12512.1 - 0.03 14.1 0.1 0.07 13.0 0.1 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Menin PF05053.13 ETO12512.1 - 0.063 11.6 10.7 0.11 10.8 10.7 1.3 1 0 0 1 1 1 0 Menin Utp14 PF04615.13 ETO12512.1 - 0.16 10.5 8.2 0.26 9.8 8.2 1.3 1 0 0 1 1 1 0 Utp14 protein Zip PF02535.22 ETO12512.1 - 1.9 7.7 5.4 3.3 6.8 5.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETO12513.1 - 4.3e-15 55.9 11.2 1.2e-07 32.3 1.4 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO12513.1 - 8.2e-05 22.1 1.4 0.00011 21.6 1.4 1.3 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO12513.1 - 0.00015 20.5 0.5 0.19 10.3 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO12513.1 - 0.00029 21.1 0.1 0.0053 17.0 0.0 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain YHYH PF14240.6 ETO12513.1 - 0.00044 20.3 0.5 0.00049 20.1 0.5 1.1 1 0 0 1 1 1 1 YHYH protein PUB PF09409.10 ETO12514.1 - 0.0001 22.2 0.1 0.00032 20.6 0.1 1.9 1 0 0 1 1 1 1 PUB domain BLM10_mid PF16507.5 ETO12515.1 - 3.5e-15 55.7 0.1 1.5e-14 53.5 0.1 1.8 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region WD40 PF00400.32 ETO12517.1 - 3e-09 37.3 3.3 8.3e-08 32.8 0.0 3.3 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12517.1 - 8.4e-07 29.2 0.1 0.0028 17.9 0.1 2.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain PALB2_WD40 PF16756.5 ETO12517.1 - 0.00093 18.2 1.5 0.95 8.3 0.1 2.7 1 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ETO12517.1 - 0.0021 16.8 0.1 0.029 13.0 0.0 2.1 1 1 1 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12517.1 - 0.0037 16.6 0.5 0.0046 16.3 0.5 1.1 1 0 0 1 1 1 1 WD40-like domain Nucleoporin_N PF08801.11 ETO12517.1 - 0.032 13.0 0.5 0.21 10.3 0.0 2.0 1 1 2 3 3 3 0 Nup133 N terminal like MHC_I_2 PF14586.6 ETO12517.1 - 0.038 13.9 0.0 0.051 13.4 0.0 1.2 1 0 0 1 1 1 0 Class I Histocompatibility antigen, NKG2D ligand, domains 1 and 2 SURF6 PF04935.12 ETO12518.1 - 1.4e-07 31.5 46.0 1.3e-06 28.4 46.0 2.1 1 1 0 1 1 1 1 Surfeit locus protein 6 LVIVD PF08309.11 ETO12519.1 - 0.0082 15.4 1.5 0.026 13.8 1.3 1.9 2 0 0 2 2 2 1 LVIVD repeat RE_Eco29kI PF09517.10 ETO12519.1 - 0.12 12.0 0.1 0.22 11.1 0.1 1.4 1 0 0 1 1 1 0 Eco29kI restriction endonuclease Kelch_2 PF07646.15 ETO12519.1 - 0.12 12.4 0.1 0.49 10.5 0.1 2.0 1 1 0 1 1 1 0 Kelch motif FYVE PF01363.21 ETO12521.1 - 8.7e-07 29.0 13.5 2e-06 27.9 13.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger PDZ PF00595.24 ETO12521.1 - 1.5e-06 28.5 0.0 3.9e-06 27.1 0.0 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO12521.1 - 2.3e-06 27.3 0.0 4.6e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain zf-HIT PF04438.16 ETO12521.1 - 0.0077 16.1 4.7 0.0077 16.1 4.7 1.6 2 0 0 2 2 2 1 HIT zinc finger Usp PF00582.26 ETO12521.1 - 6.2 7.3 5.6 23 5.5 2.2 2.4 2 0 0 2 2 2 0 Universal stress protein family AAA PF00004.29 ETO12522.1 - 2.8e-37 128.1 0.0 5.3e-37 127.2 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO12522.1 - 3e-07 30.1 0.0 2.4e-06 27.2 0.0 2.3 2 0 0 2 2 2 1 AAA+ lid domain RuvB_N PF05496.12 ETO12522.1 - 4.2e-05 23.3 0.0 8.6e-05 22.3 0.0 1.5 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ETO12522.1 - 5.3e-05 23.4 0.0 9.7e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ETO12522.1 - 0.0001 22.3 0.0 0.00071 19.6 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Vps4_C PF09336.10 ETO12522.1 - 0.00015 21.7 0.0 0.0004 20.3 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ETO12522.1 - 0.00056 19.9 0.0 0.0015 18.5 0.0 1.7 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain TIP49 PF06068.13 ETO12522.1 - 0.00088 18.6 0.0 0.0014 17.9 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_22 PF13401.6 ETO12522.1 - 0.0016 18.7 0.2 0.27 11.5 0.2 2.6 1 1 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETO12522.1 - 0.0045 16.4 0.0 0.011 15.2 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ASD1 PF08688.10 ETO12522.1 - 0.0084 16.5 1.2 0.018 15.5 1.2 1.5 1 0 0 1 1 1 1 Apx/Shroom domain ASD1 TniB PF05621.11 ETO12522.1 - 0.011 15.2 0.0 1.5 8.2 0.0 2.5 1 1 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 ETO12522.1 - 0.017 15.5 0.1 0.23 11.8 0.1 2.5 1 1 0 1 1 1 0 AAA ATPase domain Bac_DnaA PF00308.18 ETO12522.1 - 0.056 13.3 0.0 0.14 12.0 0.0 1.6 1 1 0 1 1 1 0 Bacterial dnaA protein AAA_18 PF13238.6 ETO12522.1 - 0.084 13.4 0.1 0.49 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETO12522.1 - 0.11 12.0 0.0 0.27 10.7 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 ETO12522.1 - 0.12 11.9 0.1 0.5 9.9 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_14 PF13173.6 ETO12522.1 - 0.13 12.3 0.0 0.32 11.1 0.0 1.7 1 0 0 1 1 1 0 AAA domain CENP-T_C PF15511.6 ETO12523.1 - 9.8e-07 28.9 0.2 2.7e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 ETO12523.1 - 0.0011 19.2 0.1 0.0032 17.7 0.0 1.9 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF PF02969.17 ETO12523.1 - 0.0022 18.1 0.0 0.0044 17.2 0.0 1.6 1 0 0 1 1 1 1 TATA box binding protein associated factor (TAF) Histone PF00125.24 ETO12523.1 - 0.004 17.5 1.9 0.0071 16.7 0.0 1.9 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 TFIID-31kDa PF02291.15 ETO12523.1 - 0.084 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IID, 31kD subunit Thioredoxin_6 PF13848.6 ETO12524.1 - 1.1e-22 80.9 3.9 1.8e-19 70.3 0.2 2.5 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin PF00085.20 ETO12524.1 - 0.089 12.8 0.1 12 6.0 0.0 2.7 1 1 1 2 2 2 0 Thioredoxin ETC_C1_NDUFA5 PF04716.14 ETO12525.1 - 0.1 12.4 0.1 0.31 10.9 0.1 1.9 1 0 0 1 1 1 0 ETC complex I subunit conserved region GEN1_C PF18380.1 ETO12525.1 - 0.51 11.3 4.4 1.3 9.9 4.4 1.6 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain DUF3464 PF11947.8 ETO12525.1 - 1.3 8.8 4.4 14 5.4 2.7 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Vfa1 PF08432.10 ETO12525.1 - 3.2 8.0 14.4 0.098 13.0 5.7 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RVT_1 PF00078.27 ETO12526.1 - 8.5e-46 156.2 0.1 2.9e-45 154.5 0.1 2.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RNase_H PF00075.24 ETO12526.1 - 3.5e-19 69.4 0.0 2.4e-18 66.7 0.0 2.6 1 0 0 1 1 1 1 RNase H Exo_endo_phos_2 PF14529.6 ETO12526.1 - 1.5e-16 60.3 1.7 3.8e-16 59.0 0.5 2.5 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase zf-RVT PF13966.6 ETO12526.1 - 0.00018 22.1 0.2 0.00018 22.1 0.2 4.7 4 0 0 4 4 4 1 zinc-binding in reverse transcriptase RVT_3 PF13456.6 ETO12526.1 - 0.0013 18.6 0.0 0.0085 15.9 0.0 2.5 2 0 0 2 2 2 1 Reverse transcriptase-like Herpes_TK_C PF08465.10 ETO12526.1 - 0.056 13.2 0.1 0.17 11.6 0.1 1.9 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal zf-CCHC PF00098.23 ETO12526.1 - 2.2 8.5 15.3 1.9 8.7 2.7 2.7 2 0 0 2 2 2 0 Zinc knuckle DUF1811 PF08838.10 ETO12528.1 - 0.13 12.6 0.7 0.86 9.9 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1811) Kelch_5 PF13854.6 ETO12529.1 - 1.2e-06 28.3 4.3 0.23 11.5 0.8 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO12529.1 - 0.00013 22.2 3.1 0.98 9.8 0.3 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO12529.1 - 0.00049 20.0 0.9 1.3 9.2 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO12529.1 - 0.015 14.9 3.4 2.6 7.7 0.0 3.5 4 1 0 4 4 4 0 Kelch motif DUF3926 PF13080.6 ETO12529.1 - 0.038 13.9 0.2 0.08 12.9 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3926) DUF3292 PF11696.8 ETO12529.1 - 0.051 12.0 0.2 0.064 11.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) WD40 PF00400.32 ETO12530.1 - 3.4e-39 132.1 28.8 3.2e-07 30.9 2.5 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12530.1 - 5.9e-13 48.9 1.3 0.013 15.8 0.0 5.9 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12530.1 - 8.8e-11 41.1 10.6 0.18 10.4 0.2 6.0 1 1 4 6 6 6 6 Nucleoporin Nup120/160 DUF1798 PF08807.10 ETO12532.1 - 0.0081 16.3 2.1 0.0081 16.3 2.1 2.1 2 0 0 2 2 2 1 Bacterial domain of unknown function (DUF1798) Ni_hydr_CYTB PF01292.20 ETO12532.1 - 0.14 11.8 0.1 0.27 10.8 0.1 1.6 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Otopetrin PF03189.13 ETO12532.1 - 0.28 10.0 5.8 0.17 10.6 1.4 1.8 1 1 1 2 2 2 0 Otopetrin GWT1 PF06423.12 ETO12532.1 - 1.2 9.3 5.2 0.75 9.9 1.9 2.0 1 1 1 2 2 2 0 GWT1 EOS1 PF12326.8 ETO12532.1 - 2.8 7.8 6.5 4.4 7.2 6.5 1.4 1 1 0 1 1 1 0 N-glycosylation protein Connexin PF00029.19 ETO12532.1 - 9 6.0 16.3 6.9 6.4 14.2 1.7 1 1 1 2 2 2 0 Connexin Acetyltransf_1 PF00583.25 ETO12535.1 - 2.4e-09 37.4 0.0 7.4e-09 35.9 0.0 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO12535.1 - 1e-07 31.9 0.0 3.8e-07 30.1 0.0 1.9 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO12535.1 - 1.2e-07 32.0 0.0 2.7e-07 30.9 0.0 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO12535.1 - 0.00033 20.6 0.0 0.00079 19.3 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_15 PF17013.5 ETO12535.1 - 0.0028 17.2 0.1 0.0055 16.2 0.1 1.7 1 1 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_3 PF13302.7 ETO12535.1 - 0.0065 17.2 0.0 0.014 16.0 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETO12535.1 - 0.022 14.9 0.0 0.047 13.8 0.0 1.6 1 0 0 1 1 1 0 GCN5-related N-acetyl-transferase PanZ PF12568.8 ETO12535.1 - 0.047 13.4 0.0 0.084 12.6 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain, PanZ Acetyltransf_9 PF13527.7 ETO12535.1 - 0.17 12.0 0.0 0.32 11.1 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain zf-RING_11 PF17123.5 ETO12536.1 - 5.6e-05 22.8 3.8 0.00016 21.4 3.8 1.8 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ETO12536.1 - 0.0038 17.5 2.1 0.0038 17.5 2.1 2.5 3 0 0 3 3 3 1 Ring finger domain DUF364 PF04016.12 ETO12537.1 - 0.088 12.4 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Putative heavy-metal chelation EVI2A PF05399.11 ETO12537.1 - 0.18 11.4 7.7 0.3 10.6 7.7 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Ctr PF04145.15 ETO12537.1 - 0.3 11.7 5.7 1.2 9.8 5.7 2.1 1 1 0 1 1 1 0 Ctr copper transporter family CPSF100_C PF13299.6 ETO12537.1 - 0.48 10.6 2.6 0.78 9.9 1.5 1.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Menin PF05053.13 ETO12537.1 - 0.89 7.8 8.9 1.2 7.4 8.9 1.1 1 0 0 1 1 1 0 Menin RIFIN PF02009.16 ETO12537.1 - 1.2 9.0 4.7 4.3 7.1 0.4 2.2 2 0 0 2 2 2 0 Rifin Presenilin PF01080.17 ETO12537.1 - 2.8 6.6 7.0 1.3 7.7 2.3 2.0 2 0 0 2 2 2 0 Presenilin NST1 PF13945.6 ETO12537.1 - 5.1 7.2 16.5 8.8 6.4 16.5 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF2076 PF09849.9 ETO12537.1 - 9.2 6.2 10.6 15 5.5 10.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Nuc_sug_transp PF04142.15 ETO12538.1 - 2.7e-07 30.1 25.9 5.1e-07 29.2 25.9 1.4 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ETO12538.1 - 2.8e-05 24.3 30.0 8e-05 22.8 8.1 2.3 2 0 0 2 2 2 2 EamA-like transporter family PUNUT PF16913.5 ETO12538.1 - 9.6e-05 21.8 4.4 9.6e-05 21.8 4.4 2.1 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport HOOK PF05622.12 ETO12539.1 - 1.1e-07 30.4 87.1 0.00011 20.6 0.8 5.1 3 2 1 4 4 4 4 HOOK protein CAMSAP_CH PF11971.8 ETO12539.1 - 4.4e-05 23.2 0.6 0.02 14.7 0.0 2.8 2 0 0 2 2 2 2 CAMSAP CH domain Leu_zip PF15294.6 ETO12539.1 - 0.0055 16.3 16.2 0.0055 16.3 16.2 5.0 3 1 2 5 5 5 2 Leucine zipper CH_2 PF06294.11 ETO12539.1 - 0.0064 16.6 0.0 0.055 13.6 0.0 2.7 1 0 0 1 1 1 1 CH-like domain in sperm protein DUF4094 PF13334.6 ETO12539.1 - 1.4 9.4 15.2 2.1 8.8 0.0 6.4 3 2 1 5 5 5 0 Domain of unknown function (DUF4094) Shugoshin_N PF07558.11 ETO12539.1 - 4.5 7.2 15.1 1.8 8.5 0.9 4.9 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region CH PF00307.31 ETO12540.1 - 1.4e-66 221.5 1.7 1e-19 70.7 0.1 5.0 4 1 1 5 5 5 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO12540.1 - 2.5e-09 36.8 0.0 0.046 13.6 0.0 3.6 3 0 0 3 3 3 3 CAMSAP CH domain DNApol_Exo PF18136.1 ETO12542.1 - 0.00038 19.7 1.8 0.00039 19.6 1.8 1.0 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain Peptidase_C4 PF00863.19 ETO12542.1 - 0.017 14.5 0.1 0.018 14.4 0.1 1.0 1 0 0 1 1 1 0 Peptidase family C4 Urate_ox_N PF06181.11 ETO12542.1 - 0.045 13.1 0.2 0.055 12.8 0.2 1.0 1 0 0 1 1 1 0 Urate oxidase N-terminal DUF4718 PF15842.5 ETO12542.1 - 0.2 11.4 4.0 0.22 11.3 4.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Peptidase_S49_N PF08496.10 ETO12542.1 - 1.3 9.1 7.8 1.5 8.9 7.8 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal ANAPC3 PF12895.7 ETO12543.1 - 0.00011 22.3 17.2 0.00024 21.2 1.1 4.1 4 0 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO12543.1 - 0.00016 22.1 0.0 0.0043 17.5 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12543.1 - 0.007 17.1 0.0 0.14 13.1 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12543.1 - 0.011 15.7 5.4 0.23 11.7 0.1 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO12543.1 - 0.012 15.3 0.0 0.045 13.4 0.0 2.0 2 0 0 2 2 2 0 TPR repeat Fis1_TPR_C PF14853.6 ETO12543.1 - 0.018 15.1 1.5 0.24 11.5 0.0 3.2 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_1 PF00515.28 ETO12543.1 - 0.85 9.5 6.9 1.2 9.0 0.1 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat Menin PF05053.13 ETO12544.1 - 4.4 5.6 19.1 6.1 5.1 19.1 1.1 1 0 0 1 1 1 0 Menin BSP_II PF05432.11 ETO12544.1 - 6 6.5 34.5 9.4 5.8 34.5 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4157 PF13699.6 ETO12545.1 - 0.045 14.0 0.6 0.12 12.7 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4157) CwfJ_C_2 PF04676.14 ETO12545.1 - 10 7.1 8.2 0.36 11.7 1.4 2.1 2 1 0 2 2 2 0 Protein similar to CwfJ C-terminus 2 Pkinase PF00069.25 ETO12546.1 - 3.8e-49 167.4 5.2 2.2e-32 112.5 0.0 3.0 1 1 2 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12546.1 - 2e-32 112.5 1.9 1.4e-31 109.8 1.9 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO12546.1 - 4.9e-06 25.6 0.0 9.6e-06 24.6 0.0 1.6 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO12546.1 - 0.0092 15.3 0.0 0.024 14.0 0.0 1.6 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ETO12546.1 - 0.013 15.4 0.0 0.02 14.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2258 PF10015.9 ETO12546.1 - 0.089 12.9 0.7 0.15 12.2 0.1 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) DUF676 PF05057.14 ETO12547.1 - 5.9e-19 68.4 0.0 1.2e-18 67.4 0.0 1.4 1 0 0 1 1 1 1 Putative serine esterase (DUF676) Glycoprotein PF03409.15 ETO12550.1 - 0.013 14.3 0.4 0.018 13.9 0.4 1.2 1 0 0 1 1 1 0 Transmembrane glycoprotein Dehydrin PF00257.19 ETO12551.1 - 4.3 7.9 4.7 11 6.5 4.7 1.6 1 0 0 1 1 1 0 Dehydrin Ank_2 PF12796.7 ETO12552.1 - 9.6e-20 71.0 5.0 1.1e-11 45.1 0.7 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO12552.1 - 8.3e-19 67.4 0.2 4.6e-10 39.6 0.1 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO12552.1 - 5.3e-15 55.6 0.5 4.4e-05 23.9 0.1 3.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO12552.1 - 1.1e-12 47.8 0.1 0.00037 20.8 0.1 4.8 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 ETO12552.1 - 2.4e-10 39.7 0.2 0.09 13.4 0.1 4.8 5 0 0 5 5 5 2 Ankyrin repeat Ig_C17orf99 PF17736.1 ETO12552.1 - 0.042 13.9 0.0 0.068 13.2 0.0 1.3 1 0 0 1 1 1 0 C17orf99 Ig domain DUF5401 PF17380.2 ETO12552.1 - 0.084 10.9 0.0 0.1 10.7 0.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5401) SPRY PF00622.28 ETO12553.1 - 1.9e-05 24.8 0.0 2.6e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 SPRY domain Tubulin PF00091.25 ETO12554.1 - 2.4e-59 200.9 0.2 4e-42 144.6 0.1 3.1 2 1 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO12554.1 - 1.4e-50 170.7 0.0 2.3e-50 170.0 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Endonuclease_NS PF01223.23 ETO12555.1 - 0.00074 19.4 0.0 0.00096 19.0 0.0 1.2 1 0 0 1 1 1 1 DNA/RNA non-specific endonuclease DUF4834 PF16118.5 ETO12556.1 - 0.07 14.1 8.0 1.8 9.6 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2681 PF10883.8 ETO12556.1 - 0.59 10.6 18.6 2.8 8.4 8.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) TraU PF06834.11 ETO12556.1 - 0.63 9.3 8.3 0.067 12.5 1.0 2.0 1 1 1 2 2 2 0 TraU protein DUF2500 PF10694.9 ETO12556.1 - 0.95 10.0 8.7 0.52 10.8 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) G0-G1_switch_2 PF15103.6 ETO12556.1 - 1.7 9.1 8.6 9.2 6.8 2.6 2.3 2 0 0 2 2 2 0 G0/G1 switch protein 2 Presenilin PF01080.17 ETO12556.1 - 2.1 7.0 6.9 3.1 6.4 6.9 1.3 1 0 0 1 1 1 0 Presenilin PBP1_TM PF14812.6 ETO12557.1 - 0.24 11.8 1.9 0.31 11.5 0.2 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal GEN1_C PF18380.1 ETO12557.1 - 2.5 9.1 5.3 0.9 10.5 2.1 1.9 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain PDEase_I PF00233.19 ETO12558.1 - 2.2e-75 253.4 7.4 2.4e-74 250.0 7.4 2.3 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase 7TM_GPCR_Srsx PF10320.9 ETO12558.1 - 0.006 16.0 0.9 0.014 14.8 0.9 1.5 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx ATG16 PF08614.11 ETO12559.1 - 0.00026 21.3 2.7 0.00026 21.3 2.7 2.6 4 0 0 4 4 4 1 Autophagy protein 16 (ATG16) TACC_C PF05010.14 ETO12559.1 - 0.0064 16.3 4.5 0.0064 16.3 4.5 1.9 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal Neur_chan_memb PF02932.16 ETO12559.1 - 0.031 14.3 1.2 0.049 13.7 1.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GerA PF03323.13 ETO12559.1 - 0.14 10.6 1.0 0.2 10.1 0.1 1.7 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein ZapB PF06005.12 ETO12559.1 - 0.72 10.3 8.1 0.18 12.3 4.0 2.2 2 0 0 2 2 2 0 Cell division protein ZapB Spc24 PF08286.11 ETO12559.1 - 2.3 8.5 8.8 21 5.4 8.8 2.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 DUF1664 PF07889.12 ETO12559.1 - 3 7.9 5.9 0.72 9.9 2.3 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DHR10 PF18595.1 ETO12559.1 - 9.3 6.3 14.7 0.73 9.9 9.0 2.1 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain WD40 PF00400.32 ETO12560.1 - 4e-13 49.6 2.4 1.8e-07 31.7 0.2 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat WD40 PF00400.32 ETO12561.1 - 6.8e-120 387.5 50.5 1.7e-08 35.0 0.4 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12561.1 - 6.7e-34 116.1 16.5 0.014 15.7 0.0 13.1 1 1 14 15 15 15 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12561.1 - 2.5e-21 76.0 9.9 0.021 13.8 0.0 11.1 1 1 5 10 10 10 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12561.1 - 6.3e-19 68.4 22.1 0.00062 19.2 0.3 8.6 3 2 6 10 10 10 9 WD40-like domain eIF2A PF08662.11 ETO12561.1 - 8.8e-10 38.8 4.5 0.12 12.2 0.0 6.4 2 2 3 7 7 7 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12561.1 - 2e-09 37.1 20.1 4.7 7.3 0.0 9.8 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO12561.1 - 3.1e-09 36.0 31.1 0.19 10.4 0.6 11.1 4 3 6 11 11 11 5 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO12561.1 - 1.3e-06 27.9 3.6 2.9e-06 26.8 3.6 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO12561.1 - 2.6e-06 27.5 0.3 1.1e-05 25.5 0.3 2.1 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO12561.1 - 1.2e-05 24.0 5.2 0.027 13.0 0.2 4.7 3 1 1 4 4 4 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO12561.1 - 1.4e-05 24.0 1.5 2.4 6.8 0.0 5.9 4 2 2 6 6 6 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Frtz PF11768.8 ETO12561.1 - 0.00014 20.3 1.4 0.052 11.9 0.0 4.4 4 2 1 5 5 5 1 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 ETO12561.1 - 0.00022 20.7 13.9 0.14 11.5 0.0 7.4 3 1 1 8 8 8 1 Neuroblastoma-amplified sequence, N terminal Pentapeptide_3 PF13576.6 ETO12561.1 - 0.001 19.2 0.6 0.0036 17.4 0.6 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Mid2 PF04478.12 ETO12561.1 - 0.003 17.4 4.5 6.4 6.6 0.0 5.5 5 2 1 6 6 5 1 Mid2 like cell wall stress sensor Read-through PF16814.5 ETO12561.1 - 0.22 11.3 2.3 8.1 6.2 0.1 4.1 3 1 1 4 4 4 0 Read-through domain DUF3475 PF11961.8 ETO12561.1 - 0.29 11.2 2.0 50 4.1 0.0 4.8 5 1 1 6 6 6 0 Domain of unknown function (DUF3475) Coatomer_WDAD PF04053.14 ETO12561.1 - 8.1 5.4 13.0 0.4 9.7 0.6 3.8 2 2 1 4 4 4 0 Coatomer WD associated region RRM_5 PF13893.6 ETO12562.1 - 0.22 11.1 3.1 0.36 10.4 2.9 1.4 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) OAD_gamma PF04277.13 ETO12562.1 - 2.9 8.6 4.4 5.5 7.7 4.4 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain ATP-synt_8 PF00895.20 ETO12562.1 - 6 7.4 5.8 0.95 10.0 1.9 1.7 2 0 0 2 2 2 0 ATP synthase protein 8 BSP_II PF05432.11 ETO12563.1 - 0.018 14.7 7.9 0.03 14.0 7.9 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nop14 PF04147.12 ETO12563.1 - 0.34 9.1 14.9 0.64 8.2 14.9 1.4 1 0 0 1 1 1 0 Nop14-like family TFB6 PF17110.5 ETO12563.1 - 0.94 9.2 6.5 2.5 7.8 6.5 1.7 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CDC45 PF02724.14 ETO12563.1 - 1.6 6.9 12.9 2.5 6.3 12.9 1.2 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 ETO12563.1 - 3 8.3 22.2 0.19 12.1 14.1 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF4637 PF15470.6 ETO12563.1 - 5.2 6.8 10.3 9.9 5.9 10.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF2457 PF10446.9 ETO12563.1 - 6.1 5.9 20.0 0.063 12.4 11.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) PI3K_1B_p101 PF10486.9 ETO12563.1 - 7.6 4.2 10.4 13 3.4 10.4 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TMEM119 PF15724.5 ETO12564.1 - 1.9 8.5 8.3 2 8.4 8.3 1.1 1 0 0 1 1 1 0 TMEM119 family RUN PF02759.19 ETO12565.1 - 0.014 15.3 0.4 0.018 15.0 0.4 1.2 1 0 0 1 1 1 0 RUN domain SlpA PF03217.14 ETO12567.1 - 1.5 9.5 6.2 0.58 10.8 2.8 2.0 1 1 1 2 2 2 0 Surface later protein A domain DUF2975 PF11188.8 ETO12568.1 - 0.11 12.4 9.5 0.024 14.5 2.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) ETRAMP PF09716.10 ETO12569.1 - 2.7 8.1 5.8 4.5 7.4 0.0 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) CRA PF06589.11 ETO12569.1 - 6.7 6.8 17.1 1.6 8.9 2.0 2.6 2 1 1 3 3 3 0 Circumsporozoite-related antigen (CRA) RNA_ligase PF09414.10 ETO12573.1 - 1.1e-28 100.6 0.2 1.5e-28 100.1 0.2 1.2 1 0 0 1 1 1 1 RNA ligase Glyco_H_20C_C PF18088.1 ETO12573.1 - 0.088 12.6 0.4 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 Glycoside Hydrolase 20C C-terminal domain Epimerase PF01370.21 ETO12574.1 - 7.7e-43 146.7 0.0 1.1e-42 146.1 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO12574.1 - 3e-28 99.2 0.0 3.2e-27 95.8 0.0 2.0 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ETO12574.1 - 0.00091 18.4 0.0 0.0067 15.6 0.0 2.1 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ETO12574.1 - 0.001 18.3 0.0 0.11 11.6 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein NAD_binding_10 PF13460.6 ETO12574.1 - 0.0011 19.0 0.0 0.0055 16.6 0.0 1.9 1 1 0 1 1 1 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ETO12574.1 - 0.0016 17.5 0.0 0.0034 16.4 0.0 1.5 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family ApbA PF02558.16 ETO12574.1 - 0.044 13.4 0.0 0.09 12.4 0.0 1.5 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ETO12574.1 - 0.047 13.1 0.0 0.079 12.3 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain RmlD_sub_bind PF04321.17 ETO12574.1 - 0.13 11.4 0.0 0.64 9.1 0.0 1.9 2 0 0 2 2 2 0 RmlD substrate binding domain Spore_coat_CotO PF14153.6 ETO12575.1 - 0.1 12.5 12.1 0.42 10.5 12.1 1.8 1 1 0 1 1 1 0 Spore coat protein CotO TFIIF_alpha PF05793.12 ETO12575.1 - 0.13 10.8 19.0 0.12 10.9 19.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) HAD_SAK_2 PF18143.1 ETO12576.1 - 0.00056 20.2 0.5 0.0016 18.7 0.0 2.0 2 0 0 2 2 2 1 HAD domain in Swiss Army Knife RNA repair proteins PBP1_TM PF14812.6 ETO12576.1 - 4.2 7.8 20.2 7.5 7.0 7.7 3.4 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glyco_hydro_100 PF12899.7 ETO12578.1 - 0.0025 16.5 0.8 0.0028 16.4 0.8 1.3 1 0 0 1 1 1 1 Alkaline and neutral invertase TFIIA PF03153.13 ETO12578.1 - 0.013 15.5 5.8 0.014 15.4 5.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3632 PF12311.8 ETO12578.1 - 0.024 15.1 0.2 0.037 14.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3632) Folliculin PF11704.8 ETO12578.1 - 0.031 14.2 4.7 0.099 12.5 1.7 2.1 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport Med3 PF11593.8 ETO12578.1 - 0.07 12.3 6.5 0.1 11.8 6.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Androgen_recep PF02166.16 ETO12578.1 - 0.12 11.2 5.7 0.14 10.9 5.7 1.1 1 0 0 1 1 1 0 Androgen receptor PH PF00169.29 ETO12579.1 - 2.1e-12 47.5 3.7 3.2e-12 46.9 3.7 1.3 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ETO12579.1 - 1.3e-05 25.6 1.9 1.8e-05 25.1 1.9 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_13 PF16652.5 ETO12579.1 - 0.0062 16.4 0.4 0.011 15.6 0.3 1.4 1 1 0 1 1 1 1 Pleckstrin homology domain 2-Hacid_dh PF00389.30 ETO12580.1 - 2.6e-17 62.7 0.0 3e-17 62.5 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain 2-Hacid_dh_C PF02826.19 ETO12580.1 - 3.8e-13 49.2 0.1 5.7e-13 48.6 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_2 PF03446.15 ETO12580.1 - 0.0053 16.9 0.0 0.011 15.9 0.0 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Pyr_redox_2 PF07992.14 ETO12580.1 - 0.03 13.6 0.1 0.037 13.2 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ETO12580.1 - 0.05 14.1 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 Putative NAD(P)-binding 3HCDH_N PF02737.18 ETO12580.1 - 0.17 11.8 0.9 0.3 10.9 0.1 1.8 3 0 0 3 3 3 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pkinase PF00069.25 ETO12581.1 - 2.7e-46 158.1 0.0 3.4e-46 157.7 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12581.1 - 2.6e-16 59.7 0.0 4.4e-16 59.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO12581.1 - 0.039 13.3 0.0 0.058 12.7 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pantoate_transf PF02548.15 ETO12582.1 - 0.089 12.2 0.2 0.12 11.7 0.2 1.1 1 0 0 1 1 1 0 Ketopantoate hydroxymethyltransferase DUF4446 PF14584.6 ETO12582.1 - 0.11 12.5 0.2 0.72 9.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) API5 PF05918.11 ETO12582.1 - 0.54 9.0 9.7 0.67 8.7 9.7 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) STAT_alpha PF01017.20 ETO12582.1 - 1.1 9.1 6.2 3.1 7.6 6.2 1.6 1 1 0 1 1 1 0 STAT protein, all-alpha domain Adhesin_E PF16747.5 ETO12583.1 - 0.045 13.8 0.1 0.092 12.8 0.1 1.5 1 0 0 1 1 1 0 Surface-adhesin protein E CaMKII_AD PF08332.10 ETO12583.1 - 0.059 13.5 0.0 0.14 12.3 0.0 1.7 1 0 0 1 1 1 0 Calcium/calmodulin dependent protein kinase II association domain tRNA-synt_1d PF00750.19 ETO12584.1 - 2e-17 63.2 5.0 5.9e-16 58.4 0.0 2.7 2 1 0 2 2 2 2 tRNA synthetases class I (R) tRNA_bind PF01588.20 ETO12584.1 - 6.2e-06 26.2 0.0 2.9e-05 24.1 0.0 2.1 2 0 0 2 2 2 1 Putative tRNA binding domain DDHD PF02862.17 ETO12584.1 - 0.08 13.1 2.8 0.16 12.1 2.8 1.4 1 0 0 1 1 1 0 DDHD domain Neur_chan_memb PF02932.16 ETO12584.1 - 0.29 11.2 1.1 0.42 10.6 1.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2052 PF09747.9 ETO12584.1 - 0.45 10.6 9.6 0.86 9.7 9.6 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO12584.1 - 0.57 8.4 11.6 0.78 8.0 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4770 PF15994.5 ETO12584.1 - 0.85 9.8 10.2 1.9 8.7 10.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RR_TM4-6 PF06459.12 ETO12584.1 - 1.7 8.4 14.5 3.1 7.6 14.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 ETO12584.1 - 1.8 7.8 8.7 2.9 7.1 8.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Cytomega_UL84 PF06284.11 ETO12584.1 - 2.1 6.7 5.6 3.1 6.1 5.6 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein ALMT PF11744.8 ETO12584.1 - 3.2 6.5 7.9 6 5.6 7.9 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 ETO12584.1 - 4.1 6.9 13.5 7 6.1 13.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Leu_zip PF15294.6 ETO12585.1 - 0.031 13.8 28.7 0.13 11.7 0.4 2.4 2 0 0 2 2 2 0 Leucine zipper DUF4763 PF15960.5 ETO12585.1 - 0.034 13.5 0.2 0.034 13.5 0.2 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4763) ZapB PF06005.12 ETO12585.1 - 0.047 14.1 1.4 0.047 14.1 1.4 5.1 2 1 2 4 4 4 0 Cell division protein ZapB DUF1411 PF07199.11 ETO12585.1 - 0.22 11.1 3.2 0.21 11.2 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) TMF_TATA_bd PF12325.8 ETO12585.1 - 0.24 11.6 39.8 0.086 13.1 9.6 3.5 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding AAA_22 PF13401.6 ETO12585.1 - 0.3 11.4 9.2 0.75 10.1 9.2 1.8 1 1 0 1 1 1 0 AAA domain Golgin_A5 PF09787.9 ETO12585.1 - 1.3 8.4 45.1 0.034 13.6 1.1 3.2 2 1 1 3 3 3 0 Golgin subfamily A member 5 PikAIV_N PF18605.1 ETO12585.1 - 1.6 8.4 11.8 0.63 9.7 0.4 3.7 4 0 0 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain YabA PF06156.13 ETO12585.1 - 2.5 8.8 34.8 0.84 10.3 0.5 4.1 2 1 2 4 4 4 0 Initiation control protein YabA DUF3138 PF11336.8 ETO12585.1 - 3.9 6.0 19.6 0.2 10.2 5.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3138) YqfQ PF14181.6 ETO12586.1 - 0.044 14.0 7.2 0.065 13.4 7.2 1.3 1 1 0 1 1 1 0 YqfQ-like protein DUF1075 PF06388.11 ETO12586.1 - 2.1 8.4 9.1 2.9 8.0 9.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1075) Merozoite_SPAM PF07133.11 ETO12586.1 - 8.3 6.4 14.4 9.9 6.1 14.4 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Hydrolase_like PF13242.6 ETO12587.1 - 0.053 13.6 0.0 0.096 12.8 0.0 1.4 1 0 0 1 1 1 0 HAD-hyrolase-like Piezo_RRas_bdg PF12166.8 ETO12587.1 - 5.8 6.1 8.5 8.3 5.6 8.5 1.2 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain Adaptin_N PF01602.20 ETO12588.1 - 5.7e-116 388.1 13.7 6.9e-116 387.9 13.7 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptin_C PF02296.16 ETO12588.1 - 7.8e-14 51.8 0.0 2.2e-13 50.4 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ETO12588.1 - 1.3e-10 41.5 0.1 1.3e-10 41.5 0.1 2.1 2 0 0 2 2 2 1 Adaptin C-terminal domain Cnd1 PF12717.7 ETO12588.1 - 2.8e-06 27.5 2.8 0.0042 17.2 0.0 2.8 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 AP4E_app_platf PF14807.6 ETO12588.1 - 0.00011 22.5 0.0 0.00045 20.5 0.0 2.1 2 0 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform Coatomer_g_Cpla PF16381.5 ETO12588.1 - 0.00075 19.6 0.0 0.0054 16.9 0.0 2.4 2 0 0 2 2 2 1 Coatomer subunit gamma-1 C-terminal appendage platform B2-adapt-app_C PF09066.10 ETO12588.1 - 0.0015 18.6 0.1 0.009 16.1 0.1 2.4 1 1 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT PF02985.22 ETO12588.1 - 0.024 14.9 0.6 5.1 7.6 0.0 3.3 2 0 0 2 2 2 0 HEAT repeat RTP1_C1 PF10363.9 ETO12588.1 - 0.074 13.2 2.6 0.1 12.8 1.0 2.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 RR_TM4-6 PF06459.12 ETO12588.1 - 0.96 9.2 5.6 1.7 8.4 5.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ADP_ribosyl_GH PF03747.14 ETO12589.1 - 3.2e-35 122.3 0.0 4e-35 121.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase FleQ PF06490.11 ETO12589.1 - 0.21 12.0 1.0 0.36 11.2 0.1 1.8 2 0 0 2 2 2 0 Flagellar regulatory protein FleQ adh_short PF00106.25 ETO12590.1 - 5.1e-43 146.8 0.0 6.8e-43 146.4 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO12590.1 - 6.2e-39 133.9 0.0 9.3e-39 133.4 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO12590.1 - 3.4e-08 33.6 0.0 1.5e-07 31.5 0.0 2.0 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO12590.1 - 0.029 13.8 0.0 0.09 12.2 0.0 1.7 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family RNA_pol_Rpb4 PF03874.16 ETO12590.1 - 0.06 13.7 0.2 0.14 12.5 0.1 1.6 2 0 0 2 2 2 0 RNA polymerase Rpb4 2-Hacid_dh_C PF02826.19 ETO12590.1 - 0.084 12.2 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Claudin_2 PF13903.6 ETO12591.1 - 0.0053 16.5 0.6 0.0053 16.5 0.6 1.5 2 0 0 2 2 2 1 PMP-22/EMP/MP20/Claudin tight junction TLP-20 PF06088.11 ETO12591.1 - 0.0081 16.1 1.7 0.0081 16.1 1.7 2.0 2 0 0 2 2 2 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PIG-F PF06699.11 ETO12594.1 - 0.035 14.3 0.2 0.065 13.4 0.2 1.5 1 1 0 1 1 1 0 GPI biosynthesis protein family Pig-F MIF4G_like_2 PF09090.11 ETO12595.1 - 2.4e-10 40.3 12.1 6.8e-10 38.9 11.0 2.1 1 1 0 1 1 1 1 MIF4G like DUF1117 PF06547.12 ETO12595.1 - 2.1 8.9 5.0 0.9 10.1 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1117) CathepsinC_exc PF08773.11 ETO12597.1 - 0.057 13.7 0.5 0.057 13.7 0.5 2.6 2 1 2 4 4 4 0 Cathepsin C exclusion domain Tudor-knot PF11717.8 ETO12599.1 - 0.0025 17.7 0.5 0.008 16.0 0.1 2.2 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain NPC1_N PF16414.5 ETO12599.1 - 0.0059 16.2 0.5 0.0096 15.5 0.5 1.3 1 0 0 1 1 1 1 Niemann-Pick C1 N terminus Agenet PF05641.12 ETO12599.1 - 0.0073 16.8 1.2 0.028 14.9 0.5 2.4 2 0 0 2 2 2 1 Agenet domain TetR_C_32 PF09209.11 ETO12599.1 - 0.039 13.9 0.0 0.07 13.1 0.0 1.3 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Tudor_4 PF18358.1 ETO12599.1 - 1.8 8.2 5.7 0.18 11.4 0.5 2.1 3 0 0 3 3 3 0 Histone methyltransferase Tudor domain Fer2 PF00111.27 ETO12600.1 - 0.00012 22.0 0.0 0.00023 21.0 0.0 1.5 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Tsg PF04668.12 ETO12601.1 - 0.03 15.0 0.2 0.051 14.3 0.2 1.3 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region Ly-6_related PF06579.12 ETO12601.1 - 0.069 13.4 0.4 0.16 12.2 0.4 1.5 1 1 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein DUF1863 PF08937.11 ETO12601.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.4 1 1 0 1 1 1 0 MTH538 TIR-like domain (DUF1863) Glyco_hydro_18 PF00704.28 ETO12602.1 - 1.8e-09 37.8 0.3 2.3e-09 37.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 SpoVAD PF07451.11 ETO12604.1 - 0.066 11.9 0.0 0.089 11.5 0.0 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) DDE_Tnp_1_4 PF13701.6 ETO12604.1 - 0.1 10.8 0.1 0.14 10.4 0.1 1.1 1 0 0 1 1 1 0 Transposase DDE domain group 1 C2 PF00168.30 ETO12606.1 - 0.00012 22.3 0.0 0.00022 21.5 0.0 1.5 1 1 0 1 1 1 1 C2 domain ODAPH PF15848.5 ETO12607.1 - 0.1 13.0 2.5 0.31 11.5 2.5 1.7 1 0 0 1 1 1 0 Odontogenesis associated phosphoprotein PAC1 PF16094.5 ETO12609.1 - 1.4e-05 24.4 0.2 2.5e-05 23.6 0.2 1.4 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 MIEAP PF16026.5 ETO12610.1 - 7.1e-13 49.2 0.1 1.2e-12 48.4 0.1 1.3 1 0 0 1 1 1 1 Mitochondria-eating protein DUF4637 PF15470.6 ETO12611.1 - 0.0095 15.7 0.6 0.01 15.6 0.6 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4637) Presenilin PF01080.17 ETO12611.1 - 0.013 14.3 1.5 0.014 14.2 1.5 1.1 1 0 0 1 1 1 0 Presenilin DUF5542 PF17696.1 ETO12611.1 - 0.018 15.1 0.1 0.022 14.9 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Connexin PF00029.19 ETO12611.1 - 0.02 14.7 4.1 0.022 14.5 4.1 1.0 1 0 0 1 1 1 0 Connexin PRC2_HTH_1 PF18118.1 ETO12611.1 - 0.021 15.6 6.8 0.026 15.3 6.8 1.1 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Mlh1_C PF16413.5 ETO12611.1 - 0.024 14.0 3.0 0.026 13.9 3.0 1.1 1 0 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus EMC3_TMCO1 PF01956.16 ETO12611.1 - 0.063 13.0 6.8 0.068 12.9 6.8 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF4834 PF16118.5 ETO12611.1 - 0.18 12.7 6.8 0.22 12.5 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EOS1 PF12326.8 ETO12611.1 - 0.27 11.1 1.8 0.31 11.0 1.8 1.2 1 0 0 1 1 1 0 N-glycosylation protein EIIBC-GUT_N PF03612.14 ETO12611.1 - 0.28 10.9 6.3 0.31 10.7 6.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Peptidase_S49_N PF08496.10 ETO12611.1 - 0.38 10.8 6.7 0.45 10.6 6.7 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2722 PF10846.8 ETO12611.1 - 0.57 9.1 10.5 0.59 9.0 10.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF3464 PF11947.8 ETO12611.1 - 0.58 9.9 4.6 0.62 9.8 4.6 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 UPF0239 PF06783.11 ETO12611.1 - 0.91 9.7 9.2 1.3 9.3 9.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) DUF2254 PF10011.9 ETO12611.1 - 0.97 8.2 2.9 1 8.1 2.9 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF4175 PF13779.6 ETO12611.1 - 1 7.2 9.3 1 7.2 9.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Nucleoside_tran PF01733.18 ETO12611.1 - 1.2 8.4 3.9 1.4 8.2 3.9 1.0 1 0 0 1 1 1 0 Nucleoside transporter CSG2 PF16965.5 ETO12611.1 - 1.5 7.7 4.7 1.5 7.7 4.7 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator MscS_TM PF12794.7 ETO12611.1 - 1.5 7.6 3.6 1.8 7.3 3.6 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 SseC PF04888.12 ETO12611.1 - 2.7 7.5 12.1 3.2 7.3 12.1 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family HSP70 PF00012.20 ETO12612.1 - 1.4e-62 211.7 2.4 6.2e-36 123.8 0.1 2.0 1 1 1 2 2 2 2 Hsp70 protein adh_short PF00106.25 ETO12614.1 - 3.3e-17 62.6 0.0 4.5e-17 62.1 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO12614.1 - 2.3e-08 33.9 0.0 4.3e-08 33.0 0.0 1.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Hist_deacetyl PF00850.19 ETO12615.1 - 1.1e-65 222.1 0.4 1.8e-39 136.0 0.1 2.5 2 0 0 2 2 2 2 Histone deacetylase domain Methyltransf_12 PF08242.12 ETO12615.1 - 7.8e-09 36.2 0.0 2.3e-08 34.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO12615.1 - 1.1e-08 35.7 0.0 3.1e-08 34.2 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO12615.1 - 2.1e-07 31.5 0.0 5.8e-07 30.1 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO12615.1 - 2.6e-06 27.3 0.0 1.8e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain RrnaAD PF00398.20 ETO12615.1 - 4.6e-05 22.6 0.0 9e-05 21.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_23 PF13489.6 ETO12615.1 - 0.0039 17.0 0.0 0.012 15.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Bac_DnaA_C PF08299.11 ETO12615.1 - 0.0056 16.7 0.1 0.016 15.3 0.1 1.7 1 0 0 1 1 1 1 Bacterial dnaA protein helix-turn-helix DREV PF05219.12 ETO12615.1 - 0.033 13.3 0.0 0.073 12.2 0.0 1.5 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_28 PF02636.17 ETO12615.1 - 0.069 12.8 0.6 0.18 11.4 0.0 1.9 2 0 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF3439 PF11921.8 ETO12615.1 - 3.3 7.7 10.8 8.6 6.3 10.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pox_MCEL PF03291.16 ETO12616.1 - 1.1e-71 241.6 3.4 2.2e-50 171.6 0.0 2.1 1 1 0 2 2 2 2 mRNA capping enzyme Methyltransf_25 PF13649.6 ETO12616.1 - 4.8e-06 27.2 0.0 1.1e-05 26.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO12616.1 - 0.00019 22.1 0.0 0.00053 20.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO12616.1 - 0.0011 19.6 0.0 0.0043 17.7 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO12616.1 - 0.0041 17.0 0.0 0.0068 16.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO12616.1 - 0.027 14.3 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain NNMT_PNMT_TEMT PF01234.17 ETO12616.1 - 0.058 12.6 0.0 0.12 11.5 0.0 1.5 1 0 0 1 1 1 0 NNMT/PNMT/TEMT family DUF3263 PF11662.8 ETO12616.1 - 0.067 13.0 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3263) O-FucT PF10250.9 ETO12617.1 - 1.5e-29 103.8 2.9 1.9e-29 103.4 2.9 1.2 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Pkinase PF00069.25 ETO12618.1 - 3.9e-43 147.7 5.5 5.4e-21 75.1 3.3 3.2 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12618.1 - 7.8e-15 54.8 2.5 3.8e-09 36.2 0.4 3.8 3 1 0 3 3 3 3 Protein tyrosine kinase Kinase-like PF14531.6 ETO12618.1 - 0.00023 20.6 0.5 0.0026 17.1 0.5 2.3 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO12618.1 - 0.3 11.0 1.2 0.43 10.5 0.5 1.5 2 0 0 2 2 2 0 Phosphotransferase enzyme family GNT-I PF03071.15 ETO12620.1 - 2.3e-89 300.2 4.0 1.1e-88 297.9 4.0 1.9 1 1 0 1 1 1 1 GNT-I family Peptidase_M24 PF00557.24 ETO12621.1 - 3.5e-35 121.6 0.1 5.2e-35 121.0 0.1 1.3 1 0 0 1 1 1 1 Metallopeptidase family M24 DUF3793 PF12672.7 ETO12621.1 - 0.00021 21.4 0.0 0.0003 20.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3793) RNase_T PF00929.24 ETO12622.1 - 1.7e-20 74.2 4.1 1.7e-09 38.4 0.0 2.9 3 1 0 3 3 3 2 Exonuclease DUF3577 PF12101.8 ETO12622.1 - 0.03 14.1 0.5 0.51 10.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3577) GPS PF01825.21 ETO12624.1 - 5.1e-07 30.1 3.6 5.1e-07 30.1 3.6 2.1 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif MgtE PF01769.16 ETO12624.1 - 0.34 11.3 7.9 0.11 12.9 4.4 1.9 2 0 0 2 2 2 0 Divalent cation transporter REJ PF02010.15 ETO12625.1 - 2.4e-18 66.2 4.3 1.7e-16 60.1 1.7 2.5 2 0 0 2 2 2 2 REJ domain Ustilago_mating PF05722.12 ETO12629.1 - 0.072 12.6 0.6 0.11 12.1 0.6 1.2 1 0 0 1 1 1 0 Ustilago B locus mating-type protein IML1 PF12257.8 ETO12631.1 - 3.8e-76 255.9 6.1 2.1e-65 220.7 3.6 3.8 2 1 0 2 2 2 2 Vacuolar membrane-associated protein Iml1 WD40 PF00400.32 ETO12632.1 - 9.2e-115 371.3 41.2 1.2e-08 35.4 0.1 15.8 16 0 0 16 16 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12632.1 - 1.1e-32 112.1 13.2 0.019 15.2 0.0 12.8 1 1 11 13 13 13 9 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO12632.1 - 1.3e-17 64.1 16.6 0.00039 19.8 0.0 7.2 5 2 3 8 8 8 6 WD40-like domain Ge1_WD40 PF16529.5 ETO12632.1 - 1.2e-14 54.0 11.0 0.067 12.1 0.0 10.5 1 1 8 11 11 11 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO12632.1 - 8.7e-07 28.5 0.5 1.9e-06 27.4 0.5 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) SGL PF08450.12 ETO12632.1 - 5e-05 23.0 1.5 9.8 5.7 0.0 5.7 3 2 0 5 5 5 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO12632.1 - 0.00032 19.3 1.1 1.3 7.5 0.1 4.3 3 1 1 4 4 4 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO12632.1 - 0.00067 19.1 14.9 19 4.4 0.0 8.3 3 2 4 9 9 9 0 Neuroblastoma-amplified sequence, N terminal Pentapeptide_4 PF13599.6 ETO12632.1 - 0.0024 18.0 0.1 0.0077 16.4 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO12632.1 - 0.0063 16.4 23.4 3.8 7.6 0.1 8.9 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO12632.1 - 0.017 15.3 0.2 0.049 13.8 0.2 1.8 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Gmad1 PF10647.9 ETO12632.1 - 0.058 13.1 0.0 0.29 10.8 0.0 2.2 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain Str_synth PF03088.16 ETO12632.1 - 0.14 12.3 4.7 28 4.9 0.0 5.9 9 1 1 10 10 9 0 Strictosidine synthase COMP PF11598.8 ETO12633.1 - 0.079 13.4 0.6 0.2 12.2 0.6 1.6 1 0 0 1 1 1 0 Cartilage oligomeric matrix protein Ras PF00071.22 ETO12634.1 - 4.4e-21 75.2 0.5 5.2e-21 74.9 0.5 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO12634.1 - 0.0036 17.5 0.2 0.011 15.9 0.0 1.8 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SNF2_N PF00176.23 ETO12634.1 - 0.031 13.0 0.0 0.034 12.9 0.0 1.1 1 0 0 1 1 1 0 SNF2 family N-terminal domain RsgA_GTPase PF03193.16 ETO12634.1 - 0.044 13.7 0.1 0.052 13.4 0.1 1.1 1 0 0 1 1 1 0 RsgA GTPase Galactosyl_T PF01762.21 ETO12634.1 - 0.064 13.1 0.0 0.078 12.8 0.0 1.1 1 0 0 1 1 1 0 Galactosyltransferase TipAS PF07739.13 ETO12634.1 - 0.11 13.1 0.2 0.11 13.0 0.2 1.2 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain p450 PF00067.22 ETO12636.1 - 1e-48 166.3 0.0 1.2e-48 166.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Ras PF00071.22 ETO12637.1 - 1.3e-11 44.4 0.0 1.8e-11 43.9 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO12637.1 - 0.0062 16.8 0.1 0.011 15.9 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Ac76 PF05814.11 ETO12637.1 - 2.8 8.0 6.8 0.37 10.8 0.2 2.2 2 0 0 2 2 2 0 Orf76 (Ac76) DcpS_C PF11969.8 ETO12638.1 - 1.2e-05 25.8 0.0 4.2e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding Nrap_D6 PF17407.2 ETO12638.1 - 0.0026 18.0 0.1 0.78 10.0 0.0 2.6 2 0 0 2 2 2 2 Nrap protein domain 6 HIT PF01230.23 ETO12638.1 - 0.034 14.9 0.0 0.077 13.7 0.0 1.6 1 0 0 1 1 1 0 HIT domain adh_short PF00106.25 ETO12639.1 - 8.2e-24 84.1 2.5 2.3e-20 72.9 2.5 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO12639.1 - 3.6e-15 56.2 1.3 1.4e-12 47.7 1.3 2.1 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO12639.1 - 7.9e-14 52.0 0.1 1.1e-13 51.5 0.1 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETO12639.1 - 3.2e-06 27.1 2.0 0.00033 20.6 1.9 2.8 1 1 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ETO12639.1 - 8.4e-05 21.9 0.2 0.00011 21.5 0.2 1.1 1 0 0 1 1 1 1 Male sterility protein Epimerase PF01370.21 ETO12639.1 - 0.00014 21.4 1.8 0.00033 20.2 1.8 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO12639.1 - 0.00075 19.0 4.7 0.0082 15.6 2.9 2.7 2 1 0 2 2 2 1 GDP-mannose 4,6 dehydratase FlpD PF02662.16 ETO12639.1 - 0.0064 16.5 1.3 0.98 9.4 0.5 2.3 2 0 0 2 2 2 1 Methyl-viologen-reducing hydrogenase, delta subunit YukC PF10140.9 ETO12639.1 - 0.022 13.6 0.0 0.035 12.9 0.0 1.3 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Shikimate_DH PF01488.20 ETO12639.1 - 0.031 14.3 0.3 0.35 10.9 0.1 2.2 2 1 0 2 2 2 0 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ETO12639.1 - 0.038 14.2 0.6 0.57 10.4 0.4 2.5 2 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain TrkA_N PF02254.18 ETO12639.1 - 0.1 12.9 1.0 5.9 7.2 0.2 3.0 1 1 1 2 2 2 0 TrkA-N domain RGS PF00615.19 ETO12640.1 - 5.9e-05 23.3 1.3 0.0004 20.6 1.3 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain CDI PF02234.19 ETO12640.1 - 0.47 10.7 0.0 0.47 10.7 0.0 3.6 4 0 0 4 4 4 0 Cyclin-dependent kinase inhibitor Fzo_mitofusin PF04799.13 ETO12640.1 - 1.8 8.1 7.5 3.5 7.2 7.5 1.4 1 0 0 1 1 1 0 fzo-like conserved region Phage_Gp23 PF10669.9 ETO12640.1 - 5.8 7.3 16.2 5.2 7.4 4.2 2.5 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) AAA PF00004.29 ETO12641.1 - 3.7e-25 88.9 0.0 6e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO12641.1 - 7.9e-06 25.9 0.0 2e-05 24.6 0.0 1.7 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO12641.1 - 8e-06 26.3 0.0 0.0011 19.3 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ETO12641.1 - 3.9e-05 23.4 0.0 6.4e-05 22.7 0.0 1.4 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ETO12641.1 - 0.00031 20.1 0.0 0.00039 19.7 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_18 PF13238.6 ETO12641.1 - 0.00038 21.0 0.5 0.0042 17.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ETO12641.1 - 0.00057 20.0 0.0 0.0036 17.4 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO12641.1 - 0.0012 19.1 0.1 0.024 14.9 0.0 2.2 1 1 1 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ETO12641.1 - 0.0019 18.0 0.0 0.0028 17.4 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO12641.1 - 0.0046 16.4 0.3 0.0099 15.3 0.3 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_28 PF13521.6 ETO12641.1 - 0.0052 17.0 0.0 0.011 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO12641.1 - 0.0055 16.9 0.0 0.013 15.7 0.0 1.7 2 0 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ETO12641.1 - 0.0067 16.2 0.0 0.018 14.7 0.0 1.8 1 1 0 1 1 1 1 Sigma-54 interaction domain TsaE PF02367.17 ETO12641.1 - 0.01 15.8 0.0 0.018 15.1 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ETO12641.1 - 0.011 15.1 0.1 0.022 14.0 0.1 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_7 PF12775.7 ETO12641.1 - 0.02 14.4 0.1 0.13 11.8 0.1 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_24 PF13479.6 ETO12641.1 - 0.023 14.4 0.0 0.04 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO12641.1 - 0.024 14.1 0.2 0.089 12.2 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein AAA_25 PF13481.6 ETO12641.1 - 0.026 14.1 0.1 0.053 13.1 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETO12641.1 - 0.037 13.7 0.2 0.13 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain ATPase PF06745.13 ETO12641.1 - 0.045 13.1 0.0 0.16 11.3 0.0 1.8 2 0 0 2 2 2 0 KaiC Cytochrom_C550 PF14495.6 ETO12641.1 - 0.053 13.2 0.1 0.088 12.5 0.1 1.3 1 0 0 1 1 1 0 Cytochrome c-550 domain AAA_14 PF13173.6 ETO12641.1 - 0.054 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 AAA domain SKI PF01202.22 ETO12641.1 - 0.066 13.3 0.1 0.75 9.9 0.0 2.1 2 0 0 2 2 2 0 Shikimate kinase Sigma54_activ_2 PF14532.6 ETO12641.1 - 0.079 13.1 0.0 0.14 12.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 ETO12641.1 - 0.11 12.4 0.2 0.26 11.2 0.0 1.7 2 0 0 2 2 2 0 NACHT domain T2SSE PF00437.20 ETO12641.1 - 0.12 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein ABC_tran PF00005.27 ETO12641.1 - 0.15 12.6 0.2 0.32 11.5 0.1 1.6 2 0 0 2 2 1 0 ABC transporter AAA_11 PF13086.6 ETO12641.1 - 0.25 11.1 0.5 0.48 10.2 0.0 1.7 2 0 0 2 2 2 0 AAA domain PT PF04886.12 ETO12642.1 - 1.2e-07 31.1 59.2 0.041 13.4 12.5 4.0 1 1 1 2 2 2 1 PT repeat Peptidase_M41 PF01434.18 ETO12643.1 - 1.3e-52 178.4 0.3 1.6e-50 171.6 0.3 2.2 1 1 0 1 1 1 1 Peptidase family M41 WW_like PF17890.1 ETO12643.1 - 0.14 12.2 0.6 2.9 8.0 0.1 2.3 2 0 0 2 2 2 0 Peptidoglycan hydrolase LytB WW-like domain Clathrin_bdg PF15045.6 ETO12644.1 - 0.088 12.8 0.6 0.38 10.8 0.6 2.2 1 0 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking Nudix_hydro PF18290.1 ETO12644.1 - 1.2 9.2 3.6 0.59 10.2 0.4 2.2 3 0 0 3 3 3 0 Nudix hydrolase domain zf-MYND PF01753.18 ETO12647.1 - 4.5e-06 26.7 9.7 4.5e-06 26.7 9.7 2.8 3 0 0 3 3 3 1 MYND finger LRR_6 PF13516.6 ETO12647.1 - 0.39 10.9 8.9 24 5.3 0.1 4.8 6 0 0 6 6 6 0 Leucine Rich repeat LRR_1 PF00560.33 ETO12647.1 - 0.58 10.9 7.7 36 5.5 0.1 4.4 3 1 0 3 3 3 0 Leucine Rich Repeat JAB PF01398.21 ETO12649.1 - 0.0046 16.9 0.5 0.014 15.3 0.5 1.8 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TMEM223 PF14640.6 ETO12650.1 - 0.073 13.2 0.2 0.079 13.1 0.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 223 BBP1_C PF15272.6 ETO12653.1 - 0.001 19.0 11.5 0.001 19.0 11.5 4.3 2 1 0 3 3 3 1 Spindle pole body component BBP1, C-terminal TSC22 PF01166.18 ETO12653.1 - 0.025 14.9 0.7 0.025 14.9 0.7 7.7 7 1 1 8 8 8 0 TSC-22/dip/bun family CTNNBL PF08216.11 ETO12654.1 - 5 7.4 10.2 5.4 7.2 0.3 2.1 1 1 1 2 2 2 0 Catenin-beta-like, Arm-motif containing nuclear CRAL_TRIO PF00650.20 ETO12655.1 - 5.1e-07 29.5 0.1 1.1e-06 28.4 0.1 1.5 1 0 0 1 1 1 1 CRAL/TRIO domain ProRS-C_1 PF09180.11 ETO12657.1 - 4.6e-24 84.4 0.2 1e-23 83.3 0.0 1.7 2 0 0 2 2 2 1 Prolyl-tRNA synthetase, C-terminal HGTP_anticodon PF03129.20 ETO12657.1 - 4.7e-08 33.1 0.1 1.6e-07 31.4 0.0 1.9 3 0 0 3 3 3 1 Anticodon binding domain DUF4992 PF16383.5 ETO12658.1 - 0.0042 16.6 0.8 0.0052 16.3 0.8 1.2 1 0 0 1 1 1 1 Domain of unknown function Amnionless PF14828.6 ETO12658.1 - 0.032 13.1 0.1 0.034 13.0 0.1 1.0 1 0 0 1 1 1 0 Amnionless Merozoite_SPAM PF07133.11 ETO12658.1 - 0.48 10.4 3.9 4.9 7.1 0.3 2.1 1 1 1 2 2 2 0 Merozoite surface protein (SPAM) Med2 PF11214.8 ETO12659.1 - 2.4 8.3 8.1 2.9 8.1 8.1 1.1 1 0 0 1 1 1 0 Mediator complex subunit 2 eIF3_subunit PF08597.10 ETO12661.1 - 0.0055 16.6 2.5 0.0055 16.6 2.5 2.2 2 0 0 2 2 2 1 Translation initiation factor eIF3 subunit DUF2486 PF10667.9 ETO12661.1 - 0.093 12.9 8.7 0.14 12.4 8.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2486) RNA_pol_Rpb1_5 PF04998.17 ETO12662.1 - 9.2e-97 323.6 0.0 1.5e-96 323.0 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_2 PF00623.20 ETO12662.1 - 2e-72 242.8 0.0 1.4e-71 240.0 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_6 PF04992.14 ETO12662.1 - 5.5e-66 222.1 0.0 1.2e-65 221.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 6 RNA_pol_Rpb1_1 PF04997.12 ETO12662.1 - 3.1e-55 187.7 0.2 8.2e-55 186.3 0.1 1.7 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 1 RNA_pol_Rpb1_3 PF04983.18 ETO12662.1 - 1.6e-47 161.4 0.0 6e-47 159.5 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_7 PF04990.12 ETO12662.1 - 2.3e-42 144.2 0.1 4.2e-42 143.3 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 7 RNA_pol_Rpb1_4 PF05000.17 ETO12662.1 - 1e-34 118.7 0.4 2.4e-34 117.5 0.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_R PF05001.13 ETO12662.1 - 0.004 17.4 111.0 0.27 11.7 7.9 6.5 6 0 0 6 6 6 5 RNA polymerase Rpb1 C-terminal repeat Herpes_BLLF1 PF05109.13 ETO12662.1 - 0.03 12.3 29.2 0.044 11.8 29.2 1.1 1 0 0 1 1 1 0 Herpes virus major outer envelope glycoprotein (BLLF1) WD40 PF00400.32 ETO12663.1 - 1.1e-19 70.4 1.9 1.3e-08 35.3 0.3 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12663.1 - 6.3e-08 32.8 1.0 0.0033 17.7 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12663.1 - 0.00027 20.0 0.5 0.25 10.3 0.1 2.9 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12663.1 - 0.00036 20.0 3.1 0.024 14.0 0.5 2.1 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO12663.1 - 0.0039 15.9 0.1 0.011 14.4 0.0 1.7 2 0 0 2 2 2 1 Nucleoporin Nup120/160 Pkinase PF00069.25 ETO12664.1 - 2e-10 40.5 1.1 3.5e-10 39.7 0.2 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12664.1 - 0.0042 16.4 0.8 0.017 14.4 0.8 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase PAC2 PF09754.9 ETO12665.1 - 4.3e-09 36.7 0.0 6.2e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 PAC2 family WD40 PF00400.32 ETO12666.1 - 1e-57 190.8 22.0 2.7e-10 40.7 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12666.1 - 2.8e-26 91.7 1.9 5.2e-05 23.5 0.0 6.9 1 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12666.1 - 6.3e-14 51.7 3.9 0.0033 16.4 0.1 5.7 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO12666.1 - 1.9e-10 41.0 0.0 0.0051 16.7 0.1 3.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO12666.1 - 1.2e-08 34.7 4.7 0.012 14.9 0.1 4.3 2 2 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO12666.1 - 4.1e-07 29.0 4.0 0.19 10.3 0.0 4.5 2 2 1 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO12666.1 - 9.4e-05 21.1 0.3 0.021 13.4 0.2 2.9 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO12666.1 - 0.0013 18.2 0.9 0.18 11.1 0.1 3.7 2 1 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal SBD PF17882.1 ETO12666.1 - 0.002 18.0 0.4 3 7.7 0.0 3.6 1 1 2 3 3 3 1 OAA-family lectin sugar binding domain PD40 PF07676.12 ETO12666.1 - 0.0034 17.3 9.0 0.41 10.7 0.3 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat NHL PF01436.21 ETO12666.1 - 0.0066 16.4 1.6 56 4.0 0.0 5.1 5 0 0 5 5 4 0 NHL repeat VID27 PF08553.10 ETO12666.1 - 0.016 14.2 0.5 2.4 7.1 0.0 3.2 1 1 1 3 3 3 0 VID27 C-terminal WD40-like domain DUF4999 PF16390.5 ETO12666.1 - 0.098 12.9 4.4 93 3.4 0.0 4.5 4 1 0 4 4 4 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO12666.1 - 0.1 12.3 2.8 46 3.8 0.0 4.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Det1 PF09737.9 ETO12666.1 - 0.16 11.0 0.0 0.26 10.3 0.0 1.3 1 0 0 1 1 1 0 De-etiolated protein 1 Det1 Resistin PF06954.11 ETO12666.1 - 2.7 8.6 9.2 2.5 8.7 0.3 4.2 1 1 3 5 5 5 0 Resistin PUB PF09409.10 ETO12667.1 - 0.12 12.3 5.1 0.061 13.3 0.6 2.5 2 1 0 2 2 2 0 PUB domain Sec8_exocyst PF04048.14 ETO12668.1 - 0.00042 20.2 3.5 0.014 15.2 0.4 2.5 2 0 0 2 2 2 2 Sec8 exocyst complex component specific domain Tubulin_C PF03953.17 ETO12669.1 - 9.4e-07 29.0 0.6 2e-06 28.0 0.1 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain SpoIISA_toxin PF14171.6 ETO12669.1 - 0.079 12.6 0.0 0.092 12.4 0.0 1.1 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Synapsin_C PF02750.14 ETO12670.1 - 7.2e-15 55.0 0.0 8.7e-15 54.8 0.0 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain Vip3A_N PF12495.8 ETO12670.1 - 0.058 13.3 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Vegetative insecticide protein 3A N terminal Synapsin PF02078.16 ETO12671.1 - 9.3e-26 90.1 0.0 1.6e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 Synapsin, N-terminal domain Synapsin_C PF02750.14 ETO12671.1 - 2.4e-17 63.1 0.1 4e-17 62.4 0.1 1.4 1 0 0 1 1 1 1 Synapsin, ATP binding domain TraI_2 PF07514.11 ETO12672.1 - 0.042 12.8 0.0 0.92 8.4 0.0 2.2 2 0 0 2 2 2 0 Putative helicase DUF3574 PF12098.8 ETO12672.1 - 0.16 11.8 0.1 3.7 7.4 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3574) Drf_GBD PF06371.13 ETO12672.1 - 0.38 10.3 3.1 0.34 10.5 0.1 2.4 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain V-ATPase_H_C PF11698.8 ETO12672.1 - 0.66 10.1 3.3 1.6 8.9 0.0 2.9 3 1 0 3 3 3 0 V-ATPase subunit H WD40 PF00400.32 ETO12673.1 - 2.6e-43 145.1 35.7 6.3e-08 33.2 0.4 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12673.1 - 1.8e-15 57.0 3.6 0.052 13.8 0.0 6.5 4 2 2 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12673.1 - 3.2e-06 26.1 20.0 0.027 13.1 0.5 6.1 2 1 5 7 7 7 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12673.1 - 2e-05 24.1 8.7 0.085 12.2 0.1 4.9 4 1 1 5 5 5 4 WD40-like domain zf-C4H2 PF10146.9 ETO12673.1 - 0.006 16.9 11.8 0.0086 16.4 11.8 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein TPR_11 PF13414.6 ETO12675.1 - 2.7e-07 30.1 7.7 1.5e-05 24.6 0.6 3.3 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO12675.1 - 8.7e-06 25.8 4.8 0.003 17.8 0.5 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12675.1 - 0.00083 19.3 6.9 0.046 13.9 0.1 4.3 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12675.1 - 0.0014 18.4 9.8 1.2 9.0 0.5 4.7 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12675.1 - 0.0095 16.7 0.0 1.6 9.8 0.0 2.9 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO12675.1 - 0.039 14.5 1.3 1.1 9.8 0.5 2.6 2 1 1 3 3 3 0 Tetratricopeptide repeat FAT PF02259.23 ETO12675.1 - 0.07 12.3 0.1 0.079 12.2 0.1 1.2 1 0 0 1 1 1 0 FAT domain SAPS PF04499.15 ETO12676.1 - 3.9e-26 91.9 22.7 5.4e-22 78.2 0.6 3.3 2 1 1 3 3 3 2 SIT4 phosphatase-associated protein TAFH PF07531.14 ETO12676.1 - 0.088 12.9 1.8 2.8 8.1 0.9 3.0 2 1 0 2 2 2 0 NHR1 homology to TAF DUF3915 PF13054.6 ETO12676.1 - 0.78 9.7 6.8 0.06 13.3 1.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Ecl1 PF12855.7 ETO12676.1 - 1.4 10.1 27.1 2.4 9.3 17.6 2.4 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins DUF4587 PF15248.6 ETO12676.1 - 2.4 9.0 4.9 33 5.4 0.4 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4587) Mucin PF01456.17 ETO12676.1 - 3.4 7.7 15.6 8.2 6.4 15.6 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein Peptidase_S49_N PF08496.10 ETO12676.1 - 6 6.9 12.7 0.78 9.8 5.0 2.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SPX PF03105.19 ETO12676.1 - 9.4 6.0 30.4 21 4.9 7.8 2.4 1 1 0 2 2 2 0 SPX domain CENP-B_dimeris PF09026.10 ETO12676.1 - 9.9 6.6 6.9 4.9 7.6 0.6 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-TRAF PF02176.18 ETO12677.1 - 0.002 18.8 2.0 0.002 18.8 2.0 3.0 3 0 0 3 3 3 1 TRAF-type zinc finger DUF2730 PF10805.8 ETO12677.1 - 0.78 9.9 8.2 0.11 12.7 2.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF2385 PF09539.10 ETO12678.1 - 0.02 15.4 0.2 0.59 10.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2385) EF-hand_1 PF00036.32 ETO12679.1 - 3.7e-06 26.1 0.1 0.0026 17.2 0.0 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO12679.1 - 3.2e-05 24.3 1.3 0.0001 22.7 0.8 2.0 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO12679.1 - 0.00015 21.4 0.3 0.37 10.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO12679.1 - 0.0015 18.4 1.0 0.91 9.4 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO12679.1 - 0.0026 18.0 2.1 0.0046 17.3 2.1 1.5 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO12679.1 - 0.02 14.4 0.5 3.2 7.4 0.0 2.7 2 0 0 2 2 2 0 EF hand DUF262 PF03235.14 ETO12679.1 - 0.13 12.5 2.9 0.15 12.2 2.9 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF4484 PF14831.6 ETO12680.1 - 0.021 14.9 0.3 0.03 14.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) GLTP PF08718.11 ETO12680.1 - 0.024 14.9 0.1 0.037 14.3 0.1 1.3 1 0 0 1 1 1 0 Glycolipid transfer protein (GLTP) DUF1635 PF07795.11 ETO12680.1 - 0.037 13.9 0.4 0.046 13.6 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Mucin PF01456.17 ETO12682.1 - 0.065 13.2 11.8 0.11 12.5 11.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 ETO12682.1 - 0.16 11.9 9.6 0.33 10.9 9.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TssO PF17561.2 ETO12683.1 - 0.018 15.2 2.2 0.033 14.3 0.1 2.0 2 0 0 2 2 2 0 Type VI secretion system, TssO Ost5 PF05251.12 ETO12684.1 - 0.0098 16.1 0.2 0.017 15.3 0.2 1.3 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 DUF2207 PF09972.9 ETO12684.1 - 0.011 14.6 0.2 0.013 14.3 0.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) YajC PF02699.15 ETO12684.1 - 3.5 7.6 5.5 11 6.0 5.5 2.0 1 1 0 1 1 1 0 Preprotein translocase subunit DUF3477 PF11963.8 ETO12685.1 - 0.056 12.7 0.1 0.084 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3477) Serpin PF00079.20 ETO12686.1 - 3.7e-33 115.3 0.3 1.9e-28 99.9 0.8 3.1 2 1 0 2 2 2 2 Serpin (serine protease inhibitor) PH PF00169.29 ETO12686.1 - 0.0089 16.5 1.1 0.1 13.1 0.4 2.8 2 0 0 2 2 2 1 PH domain Roughex PF06020.11 ETO12686.1 - 0.22 10.6 1.9 0.39 9.8 1.9 1.3 1 0 0 1 1 1 0 Drosophila roughex protein RRM_1 PF00076.22 ETO12687.1 - 0.00012 21.8 0.0 0.00029 20.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO12687.1 - 0.041 13.5 0.0 0.077 12.6 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 ETO12688.1 - 3.5e-15 56.1 0.3 1.1e-11 44.6 0.0 2.9 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12688.1 - 1.6e-05 24.4 0.0 0.014 14.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase CDC45 PF02724.14 ETO12689.1 - 0.0025 16.2 20.5 0.0035 15.7 20.5 1.2 1 0 0 1 1 1 1 CDC45-like protein Merozoite_SPAM PF07133.11 ETO12689.1 - 0.01 15.8 47.2 0.023 14.7 47.2 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) ZZ PF00569.17 ETO12689.1 - 0.054 13.3 4.2 0.14 12.0 4.2 1.7 1 1 0 1 1 1 0 Zinc finger, ZZ type Nop14 PF04147.12 ETO12689.1 - 0.096 10.9 36.7 0.14 10.4 36.7 1.2 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 ETO12689.1 - 0.29 9.6 15.7 0.46 9.0 15.7 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.12 ETO12689.1 - 0.32 10.4 41.1 0.51 9.7 41.1 1.3 1 0 0 1 1 1 0 SDA1 CobT PF06213.12 ETO12689.1 - 0.4 10.0 27.8 0.62 9.4 27.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT HGTP_anticodon2 PF12745.7 ETO12689.1 - 0.44 10.0 14.1 0.76 9.2 14.1 1.4 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CCSAP PF15748.5 ETO12689.1 - 0.64 10.1 11.5 1.1 9.3 11.5 1.5 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Paf1 PF03985.13 ETO12689.1 - 0.85 8.5 28.1 1.3 7.9 28.1 1.3 1 0 0 1 1 1 0 Paf1 BUD22 PF09073.10 ETO12689.1 - 1.2 8.4 34.0 2 7.7 34.0 1.3 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO12689.1 - 3 6.5 12.2 4.2 6.0 12.2 1.3 1 0 0 1 1 1 0 Presenilin DNA_pol_phi PF04931.13 ETO12689.1 - 7.3 4.5 41.1 16 3.4 41.1 1.6 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ETO12690.1 - 5.6e-124 400.4 55.8 2.1e-11 44.1 0.9 12.4 12 0 0 12 12 12 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12690.1 - 8.1e-47 157.5 8.5 0.00067 19.9 0.0 11.8 1 1 11 12 12 12 12 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO12690.1 - 1.1e-27 97.2 9.0 0.00083 18.8 0.1 8.9 3 2 5 8 8 8 8 WD40-like domain eIF2A PF08662.11 ETO12690.1 - 2e-20 73.5 0.0 0.00071 19.5 0.0 5.7 1 1 7 8 8 8 8 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO12690.1 - 3.5e-17 62.4 4.9 0.87 8.5 0.0 10.1 1 1 9 11 11 11 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO12690.1 - 3.7e-11 42.4 17.7 2.2 6.8 0.2 10.6 2 2 8 11 11 11 5 Nucleoporin Nup120/160 PD40 PF07676.12 ETO12690.1 - 1e-10 41.3 14.9 5.6 7.0 0.0 9.5 9 0 0 9 9 9 2 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETO12690.1 - 2.6e-07 29.4 0.0 0.69 8.2 0.0 5.9 1 1 5 8 8 8 4 WD repeat-containing and planar cell polarity effector protein Fritz FCP1_C PF09309.10 ETO12690.1 - 0.00066 19.6 0.0 25 4.7 0.0 5.8 5 1 0 7 7 7 0 FCP1, C-terminal DHFR_2 PF06442.11 ETO12690.1 - 0.0027 17.5 0.0 44 4.0 0.0 5.2 5 1 1 6 6 6 0 R67 dihydrofolate reductase CNH PF00780.22 ETO12690.1 - 0.0041 16.8 0.1 42 3.6 0.0 6.0 7 1 2 9 9 9 0 CNH domain Methyltransf_10 PF05971.12 ETO12690.1 - 0.0048 16.3 0.0 8 5.7 0.0 4.7 4 2 2 6 6 6 1 RNA methyltransferase Cytochrom_D1 PF02239.16 ETO12690.1 - 0.012 14.2 9.9 0.61 8.6 0.2 5.0 1 1 3 6 6 6 0 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO12690.1 - 0.36 10.9 20.0 27 4.9 0.1 8.3 3 2 7 11 11 11 0 Family of unknown function (DUF5570) KASH_CCD PF14662.6 ETO12691.1 - 0.0051 16.7 2.1 0.0051 16.7 2.1 3.1 2 1 1 3 3 3 1 Coiled-coil region of CCDC155 or KASH SlyX PF04102.12 ETO12691.1 - 0.026 15.1 11.3 0.51 11.0 0.7 2.9 2 1 0 2 2 2 0 SlyX Cas6b_C PF17262.2 ETO12691.1 - 0.035 14.2 1.3 0.035 14.2 1.3 2.6 2 0 0 2 2 2 0 Cas6b C-terminal domain DUF4200 PF13863.6 ETO12691.1 - 0.2 12.1 33.3 0.49 10.8 16.9 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DUF3450 PF11932.8 ETO12691.1 - 0.21 10.9 18.6 0.25 10.6 9.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 ETO12691.1 - 0.37 10.1 13.9 0.54 9.6 13.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CLZ PF16526.5 ETO12691.1 - 0.42 11.0 14.3 4.8 7.6 0.9 2.8 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels THOC7 PF05615.13 ETO12691.1 - 0.67 10.2 16.7 1.2 9.4 9.7 2.6 2 0 0 2 2 2 0 Tho complex subunit 7 TolA_bind_tri PF16331.5 ETO12691.1 - 0.87 9.7 10.4 11 6.2 4.7 2.7 2 1 0 2 2 2 0 TolA binding protein trimerisation TMF_DNA_bd PF12329.8 ETO12691.1 - 2.5 8.1 33.6 0.78 9.8 3.8 3.2 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF4391 PF14335.6 ETO12692.1 - 2 8.0 9.3 3.5 7.3 9.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4391) DUF5054 PF16477.5 ETO12693.1 - 8e-09 35.7 0.1 2.1e-08 34.3 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5054) SUIM_assoc PF16619.5 ETO12693.1 - 0.046 13.8 0.4 0.11 12.6 0.1 1.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 AA_permease_N PF08403.10 ETO12693.1 - 0.049 13.1 0.0 0.1 12.1 0.0 1.4 1 0 0 1 1 1 0 Amino acid permease N-terminal GBP PF02263.19 ETO12694.1 - 2.4e-06 27.0 0.2 0.0001 21.7 0.0 2.1 1 1 1 2 2 2 1 Guanylate-binding protein, N-terminal domain RHD3 PF05879.12 ETO12694.1 - 1.1e-05 23.9 0.1 1.5e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) MMR_HSR1 PF01926.23 ETO12694.1 - 1.8e-05 24.8 0.1 5.3e-05 23.3 0.1 1.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETO12694.1 - 0.001 19.1 0.0 0.0016 18.5 0.0 1.5 1 1 0 1 1 1 1 Dynamin family AAA_28 PF13521.6 ETO12694.1 - 0.013 15.8 0.1 0.036 14.3 0.1 1.7 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO12694.1 - 0.021 15.2 0.0 0.033 14.6 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO12694.1 - 0.027 15.0 0.1 0.038 14.5 0.1 1.4 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ETO12694.1 - 0.051 14.1 0.1 0.12 12.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ETO12694.1 - 0.068 13.0 0.3 0.11 12.3 0.3 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETO12694.1 - 0.076 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain Adeno_IVa2 PF02456.15 ETO12694.1 - 0.084 11.7 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Adenovirus IVa2 protein 5_nucleotid PF05761.14 ETO12695.1 - 7.5e-05 21.8 0.1 9.9e-05 21.4 0.1 1.2 1 0 0 1 1 1 1 5' nucleotidase family zf-PARP PF00645.18 ETO12696.1 - 1.2e-21 77.3 2.6 1.2e-21 77.3 2.6 2.7 2 1 0 2 2 2 1 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region SAP PF02037.27 ETO12696.1 - 2.8e-09 36.5 1.0 4.1e-09 36.0 0.0 1.8 2 0 0 2 2 2 1 SAP domain SAP30_Sin3_bdg PF13867.6 ETO12696.1 - 0.0075 16.6 0.1 0.019 15.3 0.1 1.7 1 0 0 1 1 1 1 Sin3 binding region of histone deacetylase complex subunit SAP30 SURF2 PF05477.11 ETO12696.1 - 0.4 10.3 22.3 0.024 14.3 14.5 2.0 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) CRT10 PF08728.10 ETO12696.1 - 3.7 5.6 9.5 3.3 5.8 9.5 1.1 1 0 0 1 1 1 0 CRT10 DUF3408 PF11888.8 ETO12696.1 - 3.8 7.6 19.5 0.56 10.4 11.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) CDC45 PF02724.14 ETO12696.1 - 4.1 5.6 22.5 5.5 5.2 22.5 1.2 1 0 0 1 1 1 0 CDC45-like protein AIF_C PF14721.6 ETO12696.1 - 9.9 6.5 13.1 0.8 10.1 5.4 2.2 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4924 PF16271.5 ETO12700.1 - 0.023 14.7 2.5 0.038 14.0 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4924) WD40 PF00400.32 ETO12702.1 - 1.7e-21 76.1 9.6 1e-06 29.3 0.9 4.7 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12702.1 - 3.3e-06 27.3 0.3 0.19 12.1 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12702.1 - 2.4e-05 23.2 1.1 0.033 12.8 0.3 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12702.1 - 0.011 15.0 1.5 0.59 9.4 0.3 2.6 1 1 2 3 3 3 0 WD40-like domain PRP9_N PF16958.5 ETO12703.1 - 0.079 13.0 5.4 0.099 12.7 5.4 1.3 1 1 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus ubiquitin PF00240.23 ETO12704.1 - 3.1e-30 103.7 12.2 1.4e-14 53.5 1.0 3.1 3 0 0 3 3 3 3 Ubiquitin family Rad60-SLD PF11976.8 ETO12704.1 - 1.6e-08 34.3 7.6 0.00081 19.2 0.7 3.2 2 1 1 3 3 3 3 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETO12704.1 - 0.0018 18.1 2.1 1.4 8.9 0.2 2.8 2 1 2 4 4 4 2 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 ETO12704.1 - 0.14 12.6 1.8 0.48 10.9 0.0 2.5 3 0 0 3 3 3 0 Ubiquitin-like domain NblA PF04485.12 ETO12705.1 - 0.013 15.9 0.3 3.8 8.0 0.0 3.4 3 0 0 3 3 3 0 Phycobilisome degradation protein nblA SUIM_assoc PF16619.5 ETO12707.1 - 0.023 14.8 2.0 0.044 13.8 2.0 1.4 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 H_PPase PF03030.16 ETO12707.1 - 0.12 11.0 0.1 0.15 10.7 0.1 1.0 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase DUF5521 PF17659.1 ETO12708.1 - 0.0012 16.9 0.2 0.0016 16.4 0.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5521) E_Pc_C PF06752.12 ETO12708.1 - 5.4 7.1 12.3 2.3 8.3 3.1 2.1 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus TFIIS_M PF07500.14 ETO12709.1 - 1.1e-13 51.6 6.6 1.1e-13 51.6 6.6 3.5 3 1 1 4 4 4 1 Transcription factor S-II (TFIIS), central domain GPR15L PF15854.5 ETO12709.1 - 7.3 6.9 6.9 35 4.7 0.7 2.7 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 JmjC PF02373.22 ETO12710.1 - 2.8e-06 27.8 3.0 3.7e-06 27.3 0.1 2.7 3 0 0 3 3 3 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ETO12710.1 - 4.3e-05 23.4 7.4 9.8e-05 22.2 7.4 1.6 1 1 0 1 1 1 1 Cupin-like domain WD40 PF00400.32 ETO12712.1 - 0.00012 22.8 0.2 0.00012 22.8 0.2 2.2 2 2 0 2 2 2 1 WD domain, G-beta repeat Ig_6 PF18452.1 ETO12712.1 - 0.057 13.0 0.0 0.093 12.3 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin domain Nup160 PF11715.8 ETO12712.1 - 0.1 11.3 0.0 0.1 11.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ndc1_Nup PF09531.10 ETO12713.1 - 0.16 10.6 15.4 0.18 10.5 15.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Neur_chan_memb PF02932.16 ETO12713.1 - 0.38 10.8 14.0 0.47 10.5 14.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5427 PF10310.9 ETO12713.1 - 0.4 9.6 25.1 0.52 9.2 25.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DDRGK PF09756.9 ETO12713.1 - 1.2 8.7 35.5 0.13 11.8 18.6 2.1 2 0 0 2 2 2 0 DDRGK domain Lin-8 PF03353.15 ETO12713.1 - 1.3 8.6 26.4 1.5 8.3 26.4 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Anoctamin PF04547.12 ETO12713.1 - 1.9 7.2 7.3 2.2 7.0 7.3 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel DUF2967 PF11179.8 ETO12713.1 - 2.4 6.2 12.4 2.6 6.1 12.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) MAS20 PF02064.15 ETO12713.1 - 9.6 6.3 24.4 5 7.2 12.9 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor ZapB PF06005.12 ETO12714.1 - 0.2 12.1 13.3 1.2 9.6 1.0 2.5 2 0 0 2 2 2 0 Cell division protein ZapB MerR-DNA-bind PF09278.11 ETO12714.1 - 0.33 11.5 0.1 0.33 11.5 0.1 2.4 2 1 1 3 3 3 0 MerR, DNA binding Retrotrans_gag PF03732.17 ETO12714.1 - 0.82 10.0 7.8 0.39 11.0 3.6 2.4 2 1 0 2 2 2 0 Retrotransposon gag protein CREPT PF16566.5 ETO12714.1 - 0.93 9.7 10.3 0.21 11.8 4.2 2.1 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour CENP-H PF05837.12 ETO12714.1 - 1.3 9.4 13.9 1.9 8.9 4.1 2.4 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Jnk-SapK_ap_N PF09744.9 ETO12714.1 - 1.8 8.8 15.1 2.3 8.4 1.7 2.3 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF948 PF06103.11 ETO12714.1 - 2.1 8.7 5.3 7.5 6.9 0.2 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) YabA PF06156.13 ETO12714.1 - 4 8.1 13.4 9 7.0 1.6 2.2 2 0 0 2 2 2 0 Initiation control protein YabA BRE1 PF08647.11 ETO12714.1 - 6.3 6.9 21.0 9.4 6.4 7.6 2.4 2 0 0 2 2 2 0 BRE1 E3 ubiquitin ligase BBS1 PF14779.6 ETO12714.1 - 9.3 5.6 8.3 1.5 8.2 2.8 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 1 UreE_C PF05194.12 ETO12715.1 - 0.39 11.2 5.0 0.13 12.7 1.7 1.9 2 0 0 2 2 2 0 UreE urease accessory protein, C-terminal domain GNAT_acetyltr_2 PF13718.6 ETO12715.1 - 2.3 7.5 6.6 3.8 6.8 3.7 2.0 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Presenilin PF01080.17 ETO12715.1 - 7 5.3 8.6 8.1 5.1 8.6 1.2 1 0 0 1 1 1 0 Presenilin SAC3_GANP PF03399.16 ETO12717.1 - 7.3e-34 117.5 4.3 4.9e-25 88.5 0.2 2.3 1 1 1 2 2 2 2 SAC3/GANP family NOA36 PF06524.12 ETO12718.1 - 0.045 13.1 7.1 0.077 12.3 7.1 1.3 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO12718.1 - 0.85 10.0 12.0 0.13 12.7 5.8 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 ETO12718.1 - 1.7 9.1 11.9 3.9 7.9 11.9 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2722 PF10846.8 ETO12719.1 - 0.00022 20.3 1.3 0.00022 20.3 1.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Androgen_recep PF02166.16 ETO12719.1 - 5.3 5.8 10.3 7.8 5.2 10.3 1.2 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 ETO12719.1 - 5.6 6.5 22.1 5.5 6.5 20.4 1.8 2 0 0 2 2 2 0 Spt20 family DUF3439 PF11921.8 ETO12720.1 - 0.077 13.0 1.9 0.11 12.5 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2992 PF11208.8 ETO12720.1 - 0.34 11.2 8.5 0.53 10.5 8.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2992) CDC45 PF02724.14 ETO12720.1 - 5.6 5.1 18.6 7.2 4.8 18.6 1.2 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO12721.1 - 1e-05 26.1 0.3 0.019 15.8 0.0 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat Acyltransferase PF01553.21 ETO12722.1 - 6e-08 32.4 0.0 1.3e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Acyltransferase WAK_assoc PF14380.6 ETO12722.1 - 0.059 14.1 3.1 0.44 11.3 2.5 2.4 2 0 0 2 2 2 0 Wall-associated receptor kinase C-terminal DUF2367 PF10164.9 ETO12722.1 - 1.9 9.0 7.9 0.32 11.5 1.0 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2367) 2-oxoacid_dh PF00198.23 ETO12723.1 - 1e-77 260.7 0.0 1.4e-77 260.2 0.0 1.2 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) E3_binding PF02817.17 ETO12723.1 - 3.1e-11 43.4 0.0 7.7e-11 42.1 0.0 1.8 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 ETO12723.1 - 6.9e-05 22.6 0.1 0.07 13.0 0.0 3.2 3 1 0 3 3 3 2 Biotin-requiring enzyme ORC6 PF05460.13 ETO12723.1 - 0.01 15.1 2.7 0.017 14.4 2.7 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF2207 PF09972.9 ETO12723.1 - 0.092 11.5 0.0 2 7.1 0.0 2.5 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) FliD_N PF02465.18 ETO12724.1 - 2.9 8.7 9.0 6.4 7.5 1.3 3.7 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus Ribosomal_60s PF00428.19 ETO12725.1 - 0.028 15.0 3.8 0.028 15.0 3.8 5.3 4 2 1 5 5 5 0 60s Acidic ribosomal protein DUF2110 PF09883.9 ETO12726.1 - 0.095 12.3 1.8 0.091 12.3 0.4 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2110) SRP9-21 PF05486.12 ETO12726.1 - 0.28 11.6 5.0 0.82 10.1 1.3 2.5 2 0 0 2 2 2 0 Signal recognition particle 9 kDa protein (SRP9) Sec62 PF03839.16 ETO12726.1 - 0.56 9.7 11.5 0.045 13.2 3.7 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 PBP1_TM PF14812.6 ETO12726.1 - 6.3 7.2 5.9 1.3 9.4 0.5 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Arabino_trans_N PF17689.1 ETO12727.1 - 0.18 11.9 0.6 3.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Arabinosyltransferase concanavalin like domain DUF2524 PF10732.9 ETO12727.1 - 0.82 10.0 5.4 0.16 12.3 1.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2524) DUF1015 PF06245.11 ETO12728.1 - 3.9e-135 450.7 0.0 4.5e-135 450.5 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1015) DUF262 PF03235.14 ETO12728.1 - 0.3 11.2 2.8 0.81 9.8 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF262 CENP-N PF05238.13 ETO12730.1 - 0.024 13.9 7.0 0.027 13.8 5.2 1.8 2 0 0 2 2 2 0 Kinetochore protein CHL4 like Med2 PF11214.8 ETO12730.1 - 0.34 11.1 7.6 0.85 9.8 6.8 2.1 1 1 1 2 2 2 0 Mediator complex subunit 2 Kelch_4 PF13418.6 ETO12731.1 - 5.8e-07 29.4 0.1 0.38 10.8 0.1 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO12731.1 - 1.1e-05 25.2 2.3 1.1 9.3 0.0 4.8 6 0 0 6 6 6 2 Kelch motif LysM PF01476.20 ETO12731.1 - 0.1 12.7 0.3 1.6 8.8 0.1 2.7 2 0 0 2 2 2 0 LysM domain Secretin_N_2 PF07655.13 ETO12731.1 - 1.2 9.7 6.9 3.8 8.1 6.9 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Kelch_2 PF07646.15 ETO12731.1 - 1.3 9.1 9.7 5.8 7.1 0.2 5.2 8 0 0 8 8 8 0 Kelch motif Kelch_1 PF01344.25 ETO12731.1 - 3.4 7.3 5.1 22 4.7 0.3 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO12731.1 - 3.8 7.9 8.3 31 5.0 0.4 4.1 4 1 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO12732.1 - 9.4e-67 219.3 8.8 4.7e-12 46.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12732.1 - 1.7e-25 89.1 0.4 0.00024 21.3 0.0 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12732.1 - 3.9e-20 72.1 0.1 0.0061 15.6 0.0 6.8 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO12732.1 - 1.2e-15 57.9 0.0 9e-07 29.0 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO12732.1 - 1.3e-11 44.1 4.7 3.1 7.9 0.1 7.2 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO12732.1 - 2.3e-07 30.5 0.1 0.013 14.9 0.0 3.5 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO12732.1 - 2.7e-05 23.0 0.7 6 5.4 0.0 5.1 1 1 3 5 5 5 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO12732.1 - 0.00014 20.5 0.2 0.01 14.4 0.0 2.8 1 1 2 3 3 3 1 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO12732.1 - 0.00017 21.7 1.1 1.4 9.1 0.0 4.8 2 2 4 6 6 6 1 Family of unknown function (DUF5570) Surfac_D-trimer PF09006.11 ETO12732.1 - 0.00018 21.3 0.2 15 5.5 0.0 5.2 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation Nbas_N PF15492.6 ETO12732.1 - 0.00098 18.5 1.6 11 5.2 0.0 4.8 1 1 4 5 5 5 0 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO12732.1 - 0.0033 16.2 3.0 0.055 12.2 1.0 3.3 1 1 0 2 2 2 1 Nup133 N terminal like DPPIV_N PF00930.21 ETO12732.1 - 0.0061 15.4 0.1 9.1 4.9 0.0 4.5 1 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Str_synth PF03088.16 ETO12732.1 - 0.0062 16.6 0.1 11 6.3 0.0 3.8 3 1 1 4 4 4 0 Strictosidine synthase DUF727 PF05303.12 ETO12732.1 - 0.013 15.5 0.1 15 5.7 0.0 3.4 3 1 1 4 4 3 0 Protein of unknown function (DUF727) Me-amine-dh_H PF06433.11 ETO12732.1 - 0.055 12.3 0.0 1.2 7.9 0.0 2.6 2 1 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) Peptidase_S9_N PF02897.15 ETO12732.1 - 0.11 11.3 0.3 3.3 6.4 0.1 2.9 2 1 0 2 2 2 0 Prolyl oligopeptidase, N-terminal beta-propeller domain Proteasome_A_N PF10584.9 ETO12732.1 - 0.27 11.0 18.1 5.1 6.9 0.0 6.5 6 1 1 7 7 7 0 Proteasome subunit A N-terminal signature TPR_12 PF13424.6 ETO12733.1 - 1.4e-26 92.5 0.2 7.1e-14 51.9 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12733.1 - 1.4e-16 59.7 0.6 6.3e-06 25.9 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12733.1 - 2.8e-16 58.3 12.4 1.5e-05 24.8 0.3 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12733.1 - 1.1e-14 53.3 2.1 0.00051 19.9 0.1 4.8 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12733.1 - 2.2e-14 52.3 6.4 0.00035 20.5 0.1 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12733.1 - 4e-14 51.7 12.8 5.8e-07 29.1 0.2 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO12733.1 - 8.9e-05 23.0 0.0 1.1 10.2 0.0 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO12733.1 - 0.00035 21.0 0.8 14 6.6 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 ETO12733.1 - 0.0006 19.9 1.0 19 5.8 0.1 4.9 5 0 0 5 5 5 0 PPR repeat MIT PF04212.18 ETO12733.1 - 0.0015 18.6 2.4 3.6 7.7 0.0 4.2 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO12733.1 - 0.0022 18.2 5.1 0.14 12.6 0.3 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO12733.1 - 0.0053 16.5 3.9 0.0065 16.2 1.0 2.5 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_16 PF13432.6 ETO12733.1 - 0.0054 17.4 0.0 0.091 13.4 0.0 2.7 3 1 0 3 3 2 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO12733.1 - 0.016 14.6 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region ANAPC3 PF12895.7 ETO12733.1 - 0.017 15.3 4.8 1.6 9.0 0.2 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO12733.1 - 0.12 12.2 8.4 0.6 9.9 0.2 3.8 2 2 2 4 4 4 0 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETO12733.1 - 0.22 12.2 1.9 14 6.5 0.2 3.7 3 1 0 3 3 3 0 Sel1 repeat TPR_11 PF13414.6 ETO12733.1 - 0.33 10.7 14.3 15 5.3 0.6 5.3 4 2 2 6 6 6 0 TPR repeat WD40 PF00400.32 ETO12734.1 - 4.3e-19 68.5 15.0 2.4e-05 25.0 0.9 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12734.1 - 3.1e-05 24.2 0.1 0.18 12.1 0.0 2.6 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12734.1 - 0.00023 20.0 2.3 0.29 9.7 0.1 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO12734.1 - 0.0029 17.0 0.3 0.019 14.3 0.1 2.0 2 0 0 2 2 2 1 WD40-like domain DUF851 PF05867.11 ETO12734.1 - 0.11 12.0 0.0 0.15 11.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF851) PADR1 PF08063.12 ETO12734.1 - 0.2 11.5 1.9 5.2 6.9 0.3 2.4 2 0 0 2 2 2 0 PADR1 (NUC008) domain UEV PF05743.13 ETO12735.1 - 3.4e-33 114.1 0.1 6.1e-33 113.3 0.1 1.4 1 0 0 1 1 1 1 UEV domain Vps23_core PF09454.10 ETO12735.1 - 2e-20 72.5 0.7 5e-20 71.2 0.7 1.7 1 0 0 1 1 1 1 Vps23 core domain UQ_con PF00179.26 ETO12735.1 - 8.6e-06 25.4 0.4 1.8e-05 24.4 0.4 1.6 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme DUF4407 PF14362.6 ETO12735.1 - 1.2 8.4 9.5 2.7 7.3 9.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC106 PF15794.5 ETO12736.1 - 0.77 9.4 6.6 0.088 12.5 1.5 1.8 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 HCO3_cotransp PF00955.21 ETO12736.1 - 1.1 8.1 2.8 1.4 7.6 2.8 1.2 1 0 0 1 1 1 0 HCO3- transporter family Menin PF05053.13 ETO12736.1 - 2.2 6.5 7.7 2.5 6.4 7.7 1.1 1 0 0 1 1 1 0 Menin Hormone_recep PF00104.30 ETO12738.1 - 0.0025 17.4 2.2 0.003 17.2 2.2 1.1 1 0 0 1 1 1 1 Ligand-binding domain of nuclear hormone receptor Metallophos_C PF14008.6 ETO12738.1 - 0.2 12.5 0.3 0.82 10.6 0.3 2.1 1 1 0 1 1 1 0 Iron/zinc purple acid phosphatase-like protein C Exo_endo_phos PF03372.23 ETO12739.1 - 0.00057 19.5 0.0 0.01 15.4 0.0 2.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Tyrosinase PF00264.20 ETO12739.1 - 0.032 14.5 1.0 0.047 14.0 0.2 1.7 2 0 0 2 2 2 0 Common central domain of tyrosinase ART PF01129.18 ETO12741.1 - 0.00011 21.6 0.0 0.00019 20.8 0.0 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase TUG-UBL1 PF11470.8 ETO12741.1 - 0.024 14.9 0.4 0.078 13.2 0.4 1.9 1 0 0 1 1 1 0 TUG ubiquitin-like domain Cys_rich_VLP PF14194.6 ETO12741.1 - 0.05 13.7 0.2 0.12 12.5 0.2 1.6 1 0 0 1 1 1 0 Cysteine-rich VLP PH PF00169.29 ETO12742.1 - 4.1e-06 27.3 8.0 0.0001 22.8 0.2 3.6 3 0 0 3 3 3 2 PH domain PH_11 PF15413.6 ETO12742.1 - 4.5e-06 27.0 7.7 0.00012 22.4 0.2 3.8 3 0 0 3 3 3 2 Pleckstrin homology domain SLATT_4 PF18186.1 ETO12742.1 - 0.0015 18.2 1.5 0.33 10.6 0.1 2.8 2 0 0 2 2 2 2 SMODS and SLOG-associating 2TM effector domain family 4 Toxin_YhaV PF11663.8 ETO12742.1 - 0.035 14.2 1.0 0.092 12.8 0.1 2.2 2 0 0 2 2 2 0 Toxin with endonuclease activity, of toxin-antitoxin system PEX11 PF05648.14 ETO12742.1 - 0.13 11.7 1.3 16 4.9 0.2 2.8 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Mei4 PF13971.6 ETO12742.1 - 0.16 11.4 7.6 0.041 13.4 2.6 2.4 3 0 0 3 3 3 0 Meiosis-specific protein Mei4 DUF1856 PF08983.10 ETO12742.1 - 1.7 9.0 7.3 0.57 10.5 1.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1856) WD40 PF00400.32 ETO12743.1 - 0.0014 19.4 0.2 0.014 16.2 0.2 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO12743.1 - 0.0025 16.5 0.0 0.0026 16.5 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 AIM3 PF17096.5 ETO12744.1 - 0.0049 17.8 0.2 0.0054 17.6 0.2 1.1 1 0 0 1 1 1 1 Altered inheritance of mitochondria protein 3 RNA_pol_3_Rpc31 PF11705.8 ETO12744.1 - 0.019 15.2 3.1 0.027 14.7 3.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.14 ETO12744.1 - 0.037 13.8 1.5 0.044 13.6 1.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SARAF PF06682.12 ETO12744.1 - 0.039 13.6 0.2 0.048 13.3 0.2 1.3 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis O-antigen_lig PF13425.6 ETO12744.1 - 0.06 12.1 0.9 0.071 11.9 0.9 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4849 PF16141.5 ETO12744.1 - 0.094 12.0 0.0 0.094 12.0 0.0 1.4 2 0 0 2 2 2 0 Putative glycoside hydrolase Family 18, chitinase_18 PBP1_TM PF14812.6 ETO12744.1 - 0.91 9.9 7.4 0.49 10.8 0.3 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_L24e PF01246.20 ETO12745.1 - 0.28 11.5 0.0 0.28 11.5 0.0 1.7 2 0 0 2 2 2 0 Ribosomal protein L24e DUF5082 PF16888.5 ETO12746.1 - 0.16 12.3 11.1 1.3 9.4 11.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF4349 PF14257.6 ETO12746.1 - 0.74 9.2 5.9 1.1 8.7 5.8 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) Exonuc_VII_L PF02601.15 ETO12746.1 - 1.2 8.6 8.0 1.4 8.5 8.0 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF883 PF05957.13 ETO12746.1 - 2 9.1 6.6 4.7 7.9 0.9 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Herpes_capsid PF06112.11 ETO12747.1 - 0.074 13.1 2.3 0.11 12.6 1.8 1.4 1 1 0 1 1 1 0 Gammaherpesvirus capsid protein Striatin PF08232.12 ETO12747.1 - 6 7.4 17.4 7.7e+02 0.6 17.4 2.2 1 1 0 1 1 1 0 Striatin family CH PF00307.31 ETO12748.1 - 0.0031 17.7 0.2 0.0037 17.4 0.2 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain G-alpha PF00503.20 ETO12749.1 - 2.9e-21 76.0 12.0 5.4e-21 75.1 12.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Dynamin_N PF00350.23 ETO12749.1 - 0.00045 20.3 1.3 0.00071 19.7 1.3 1.3 1 0 0 1 1 1 1 Dynamin family Rad17 PF03215.15 ETO12749.1 - 0.00095 19.1 0.1 0.00095 19.1 0.1 2.0 2 0 0 2 2 2 1 Rad17 P-loop domain AAA_29 PF13555.6 ETO12749.1 - 0.0021 17.8 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain MCM PF00493.23 ETO12749.1 - 0.0096 15.0 0.7 0.029 13.5 0.1 1.9 1 1 1 2 2 2 1 MCM P-loop domain SLC12 PF03522.15 ETO12749.1 - 0.014 14.5 10.2 0.017 14.2 10.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PRK PF00485.18 ETO12749.1 - 0.014 15.1 0.1 0.014 15.1 0.1 1.8 1 1 1 2 2 2 0 Phosphoribulokinase / Uridine kinase family Hid1 PF12722.7 ETO12749.1 - 0.023 12.9 8.0 0.025 12.7 8.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO12749.1 - 0.027 13.3 10.3 0.034 12.9 10.3 1.1 1 0 0 1 1 1 0 Presenilin AAA_21 PF13304.6 ETO12749.1 - 0.079 12.8 1.5 0.14 11.9 1.5 1.5 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system GPCR_chapero_1 PF11904.8 ETO12749.1 - 0.11 11.9 8.5 0.13 11.7 8.5 1.2 1 0 0 1 1 1 0 GPCR-chaperone DUF2052 PF09747.9 ETO12749.1 - 0.12 12.5 18.7 0.18 11.9 18.7 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO12749.1 - 0.12 10.7 16.8 0.15 10.3 16.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 ETO12749.1 - 0.15 11.0 21.5 0.19 10.7 21.5 1.1 1 0 0 1 1 1 0 Paf1 RR_TM4-6 PF06459.12 ETO12749.1 - 0.23 11.3 17.5 0.32 10.8 17.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 ETO12749.1 - 0.3 11.1 6.6 0.43 10.6 6.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 ETO12749.1 - 0.39 10.6 2.9 0.59 10.0 2.9 1.3 1 0 0 1 1 1 0 N-glycosylation protein AAA_16 PF13191.6 ETO12749.1 - 0.4 11.0 3.2 0.87 10.0 3.1 1.8 1 1 0 1 1 1 0 AAA ATPase domain GAGA_bind PF06217.12 ETO12749.1 - 0.41 10.9 10.6 0.5 10.6 10.6 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Rtf2 PF04641.12 ETO12749.1 - 0.42 9.9 18.7 0.62 9.4 18.7 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger ABC_tran PF00005.27 ETO12749.1 - 0.69 10.4 13.5 2.9 8.4 13.5 2.0 1 1 0 1 1 1 0 ABC transporter TP53IP5 PF15331.6 ETO12749.1 - 0.73 10.0 12.0 1.2 9.2 12.0 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Dsh_C PF12316.8 ETO12749.1 - 0.75 10.2 3.8 0.33 11.3 1.8 1.4 2 0 0 2 2 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF913 PF06025.12 ETO12749.1 - 0.83 8.6 6.2 1.1 8.2 6.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO12749.1 - 1.2 8.3 7.6 1.7 7.8 7.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 ETO12749.1 - 5.2 5.8 12.0 7 5.4 12.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3169 PF11368.8 ETO12750.1 - 0.0004 20.0 0.3 0.00053 19.6 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) FAM176 PF14851.6 ETO12750.1 - 0.0025 17.5 0.5 0.0025 17.5 0.5 1.1 1 0 0 1 1 1 1 FAM176 family V_ATPase_I PF01496.19 ETO12750.1 - 0.0046 15.0 1.7 0.0053 14.7 1.7 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family MLANA PF14991.6 ETO12750.1 - 0.0059 16.9 0.2 0.0074 16.6 0.2 1.1 1 0 0 1 1 1 1 Protein melan-A DUF4446 PF14584.6 ETO12750.1 - 0.01 15.8 1.7 0.013 15.5 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Peptidase_S49_N PF08496.10 ETO12750.1 - 0.013 15.6 4.3 0.014 15.4 4.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal CHD5 PF04420.14 ETO12750.1 - 0.037 13.9 0.9 0.053 13.4 0.9 1.2 1 0 0 1 1 1 0 CHD5-like protein DUF3523 PF12037.8 ETO12750.1 - 0.082 12.3 5.8 0.095 12.1 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Serinc PF03348.15 ETO12750.1 - 0.094 11.6 0.1 0.11 11.4 0.1 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) CLN3 PF02487.17 ETO12750.1 - 0.31 10.0 1.1 0.32 10.0 1.1 1.0 1 0 0 1 1 1 0 CLN3 protein WD40 PF00400.32 ETO12752.1 - 4.5e-19 68.4 14.3 5.8e-05 23.8 0.0 5.4 4 1 1 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO12752.1 - 0.0057 15.4 0.2 0.12 11.0 0.2 2.1 1 1 0 1 1 1 1 Nucleoporin Nup120/160 DUF4200 PF13863.6 ETO12752.1 - 0.015 15.7 13.3 0.015 15.7 13.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) She9_MDM33 PF05546.11 ETO12752.1 - 0.025 14.4 4.4 0.049 13.4 4.4 1.4 1 0 0 1 1 1 0 She9 / Mdm33 family Phage_HK97_TLTM PF06120.11 ETO12752.1 - 0.038 13.2 6.7 0.057 12.6 6.7 1.3 1 0 0 1 1 1 0 Tail length tape measure protein MRPL52 PF18699.1 ETO12752.1 - 0.31 11.2 8.6 0.89 9.8 8.6 1.7 1 0 0 1 1 1 0 Mitoribosomal protein mL52 GCD14 PF08704.10 ETO12752.1 - 0.45 10.1 4.2 0.28 10.8 2.1 1.8 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit RIC3 PF15361.6 ETO12752.1 - 2.5 8.5 7.1 5.2 7.4 7.1 1.5 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 DUF641 PF04859.12 ETO12752.1 - 2.7 8.4 11.8 1.4 9.2 8.7 2.0 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) HIP1_clath_bdg PF16515.5 ETO12752.1 - 2.9 8.5 12.2 1.5 9.5 9.4 1.9 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Jnk-SapK_ap_N PF09744.9 ETO12752.1 - 5.2 7.3 16.7 1.7 8.9 9.4 2.1 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 SR-25 PF10500.9 ETO12754.1 - 3.2 7.3 11.3 4.7 6.8 11.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ETO12755.1 - 1.6e-22 80.2 0.0 4.4e-18 65.6 0.0 3.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12755.1 - 6.5e-21 74.8 0.0 3.2e-15 56.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO12755.1 - 0.0074 15.7 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SRP72 PF08492.12 ETO12755.1 - 0.7 10.4 9.5 0.63 10.5 7.5 2.0 1 1 0 1 1 1 0 SRP72 RNA-binding domain Tub_N PF16322.5 ETO12755.1 - 1.1 9.7 22.3 2.1 8.7 17.8 2.4 2 0 0 2 2 2 0 Tubby N-terminal DNA_pol_phi PF04931.13 ETO12755.1 - 5.9 4.9 20.9 9.8 4.1 20.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO12755.1 - 6.1 4.9 28.6 1.2 7.3 24.9 1.5 2 0 0 2 2 2 0 Nop14-like family DEAD PF00270.29 ETO12756.1 - 0.056 13.2 0.3 0.13 12.0 0.1 1.6 2 0 0 2 2 2 0 DEAD/DEAH box helicase CTU2 PF10288.9 ETO12756.1 - 0.17 12.2 1.1 4.2 7.7 0.7 2.8 3 0 0 3 3 3 0 Cytoplasmic tRNA 2-thiolation protein 2 DUF1104 PF06518.11 ETO12756.1 - 0.71 10.3 7.9 0.13 12.6 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1104) RelB PF04221.12 ETO12757.1 - 0.053 13.5 0.0 0.11 12.5 0.0 1.5 1 0 0 1 1 1 0 RelB antitoxin DUF3890 PF13029.6 ETO12757.1 - 6 7.4 9.7 19 5.8 0.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF3890) DUF2208 PF09973.9 ETO12758.1 - 0.0035 17.0 2.7 0.0049 16.5 2.7 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2208) 2TM PF13239.6 ETO12758.1 - 0.088 13.1 1.1 0.19 12.0 1.1 1.5 1 0 0 1 1 1 0 2TM domain Kelch_1 PF01344.25 ETO12759.1 - 0.00048 19.7 0.0 0.0074 15.9 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO12759.1 - 0.004 17.1 0.2 0.047 13.7 0.0 2.4 2 1 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO12759.1 - 0.0064 16.7 0.0 0.14 12.4 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO12759.1 - 0.01 16.1 0.0 0.078 13.3 0.0 2.3 2 1 0 2 2 2 0 Galactose oxidase, central domain DUF5128 PF17170.4 ETO12759.1 - 0.021 14.0 0.3 0.031 13.4 0.3 1.3 1 0 0 1 1 1 0 6-bladed beta-propeller Kelch_5 PF13854.6 ETO12759.1 - 0.044 13.8 0.9 0.15 12.1 0.2 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO12759.1 - 0.047 13.7 2.3 0.26 11.3 0.7 2.9 3 1 0 3 3 3 0 Kelch motif ATP11 PF06644.11 ETO12760.1 - 0.022 14.5 4.6 0.025 14.4 3.7 1.4 1 1 1 2 2 2 0 ATP11 protein CPSase_L_D3 PF02787.19 ETO12760.1 - 0.025 14.9 3.6 0.041 14.2 3.5 1.4 1 1 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain SR-25 PF10500.9 ETO12761.1 - 2.4 7.7 11.6 4.3 6.9 11.6 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ubiquitin PF00240.23 ETO12762.1 - 4e-14 52.1 3.5 4e-14 52.1 3.5 2.5 2 1 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ETO12762.1 - 5.3e-06 26.2 2.7 0.0001 22.1 2.7 2.3 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO12762.1 - 0.0015 19.1 1.8 0.0024 18.4 1.7 1.5 1 1 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO12762.1 - 0.0082 16.2 1.9 0.017 15.2 1.4 1.8 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Coilin_N PF15862.5 ETO12762.1 - 0.0083 15.9 5.6 0.01 15.6 5.6 1.1 1 0 0 1 1 1 1 Coilin N-terminus Pyr_redox_2 PF07992.14 ETO12763.1 - 6.2e-28 97.9 0.0 7.8e-28 97.5 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO12763.1 - 6.5e-07 29.8 0.1 0.04 14.5 0.0 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Melibiase_2 PF16499.5 ETO12764.1 - 1.5e-13 50.6 0.0 3.1e-13 49.5 0.0 1.5 2 0 0 2 2 2 1 Alpha galactosidase A Melibiase_C PF17801.1 ETO12764.1 - 0.00077 19.5 0.0 0.0012 18.9 0.0 1.3 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 ETO12764.1 - 0.011 15.9 0.0 0.024 14.9 0.0 1.5 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain Melibiase_2 PF16499.5 ETO12765.1 - 4.9e-20 71.8 6.1 4.9e-19 68.6 6.1 2.3 1 1 0 1 1 1 1 Alpha galactosidase A CAP_GLY PF01302.25 ETO12767.1 - 2.6e-09 37.0 0.0 4.7e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain SID-1_RNA_chan PF13965.6 ETO12767.1 - 6.7 5.0 8.4 0.12 10.8 0.2 1.9 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Pkinase PF00069.25 ETO12769.1 - 1.4e-17 64.0 0.8 8.9e-07 28.5 0.0 3.2 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12769.1 - 1.5e-05 24.4 0.4 0.0089 15.3 0.0 3.3 3 0 0 3 3 3 1 Protein tyrosine kinase Mucin PF01456.17 ETO12769.1 - 0.0079 16.2 29.1 0.013 15.5 29.1 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein Kinase-like PF14531.6 ETO12769.1 - 0.019 14.3 0.0 0.54 9.5 0.0 2.1 2 0 0 2 2 2 0 Kinase-like AF-4 PF05110.13 ETO12769.1 - 0.071 11.2 11.7 0.093 10.8 11.7 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SOG2 PF10428.9 ETO12769.1 - 0.1 11.8 13.1 0.14 11.3 13.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Zip PF02535.22 ETO12769.1 - 0.25 10.5 8.8 0.37 10.0 8.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NST1 PF13945.6 ETO12769.1 - 0.35 10.9 19.9 0.78 9.8 19.9 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator FAM199X PF15814.5 ETO12769.1 - 1.5 7.8 10.3 2.5 7.1 10.3 1.3 1 0 0 1 1 1 0 Protein family FAM199X FSA_C PF10479.9 ETO12769.1 - 1.8 6.6 14.4 2.7 6.0 14.4 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RIFIN PF02009.16 ETO12769.1 - 3.5 7.4 7.5 5.6 6.8 7.5 1.4 1 0 0 1 1 1 0 Rifin FAM76 PF16046.5 ETO12769.1 - 7.6 5.8 13.1 13 5.1 13.1 1.3 1 0 0 1 1 1 0 FAM76 protein Macoilin PF09726.9 ETO12769.1 - 8.5 4.8 19.7 12 4.3 19.7 1.1 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO12769.1 - 8.5 4.6 10.4 13 4.0 10.4 1.2 1 0 0 1 1 1 0 Menin G-alpha PF00503.20 ETO12770.1 - 1.8e-28 99.7 0.4 2.4e-28 99.3 0.4 1.2 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO12770.1 - 0.0039 17.7 0.0 0.0057 17.2 0.0 1.4 1 0 0 1 1 1 1 ABC transporter Rad17 PF03215.15 ETO12770.1 - 0.016 15.1 0.0 0.026 14.5 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain F_actin_bind PF08919.10 ETO12770.1 - 0.024 14.8 0.1 0.041 14.0 0.1 1.5 1 0 0 1 1 1 0 F-actin binding AAA_29 PF13555.6 ETO12770.1 - 0.026 14.3 0.1 0.049 13.4 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO12770.1 - 0.027 14.9 0.0 0.031 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ETO12770.1 - 0.028 13.8 0.0 0.06 12.7 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family HEPN_Cthe2314 PF18730.1 ETO12770.1 - 0.061 13.4 4.5 4 7.4 0.2 2.4 2 0 0 2 2 2 0 Cthe_2314-like HEPN AAA_18 PF13238.6 ETO12770.1 - 0.085 13.4 0.0 0.13 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO12770.1 - 0.088 12.7 0.1 0.24 11.3 0.1 1.8 1 0 0 1 1 1 0 NACHT domain AAA_28 PF13521.6 ETO12770.1 - 0.1 12.9 0.0 0.17 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ETO12770.1 - 0.1 12.3 0.1 0.25 11.0 0.0 1.7 1 1 1 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_33 PF13671.6 ETO12770.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DEAD PF00270.29 ETO12771.1 - 9.6e-41 139.5 0.3 1.1e-40 139.3 0.3 1.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO12771.1 - 1.4e-06 28.4 0.0 1.7e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETO12771.1 - 3.5e-05 23.6 0.1 4.9e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 AAA domain CMS1 PF14617.6 ETO12771.1 - 4.9e-05 22.8 0.1 6.9e-05 22.3 0.1 1.4 1 1 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 ETO12771.1 - 6.3e-05 23.3 0.3 8.8e-05 22.9 0.3 1.3 1 1 0 1 1 1 1 AAA domain Helicase_RecD PF05127.14 ETO12771.1 - 0.00015 21.6 0.0 0.0002 21.3 0.0 1.2 1 0 0 1 1 1 1 Helicase PhoH PF02562.16 ETO12771.1 - 0.0025 17.3 0.2 0.003 17.0 0.2 1.3 1 1 0 1 1 1 1 PhoH-like protein SWI2_SNF2 PF18766.1 ETO12771.1 - 0.0061 16.3 0.0 0.0068 16.1 0.0 1.1 1 0 0 1 1 1 1 SWI2/SNF2 ATPase Flavi_DEAD PF07652.14 ETO12771.1 - 0.012 15.6 0.0 0.029 14.3 0.0 1.9 1 1 0 1 1 1 0 Flavivirus DEAD domain DUF3638 PF12340.8 ETO12771.1 - 0.045 13.1 0.2 1.1 8.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3638) AAA_22 PF13401.6 ETO12771.1 - 0.065 13.5 0.4 0.25 11.6 0.4 1.9 1 1 0 1 1 1 0 AAA domain Y_phosphatase PF00102.27 ETO12771.1 - 0.13 11.8 0.1 0.17 11.4 0.1 1.1 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Pkinase PF00069.25 ETO12772.1 - 0.021 14.2 0.1 0.16 11.3 0.0 2.2 2 1 1 3 3 3 0 Protein kinase domain TPR_12 PF13424.6 ETO12773.1 - 4.5e-06 26.9 0.0 9.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12773.1 - 0.0015 18.3 0.0 0.0048 16.7 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Geminin PF07412.12 ETO12773.1 - 0.0044 16.8 4.4 0.0064 16.2 4.4 1.4 1 0 0 1 1 1 1 Geminin TPR_2 PF07719.17 ETO12773.1 - 0.016 15.2 0.1 0.13 12.5 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12773.1 - 0.019 15.1 0.0 0.055 13.7 0.0 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat SUKH_5 PF14567.6 ETO12773.1 - 0.043 13.5 0.9 0.15 11.8 0.0 2.0 2 0 0 2 2 2 0 SMI1-KNR4 cell-wall TPR_1 PF00515.28 ETO12773.1 - 0.059 13.2 1.1 0.14 12.0 0.2 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12773.1 - 0.086 12.9 0.1 0.34 11.0 0.1 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat BTB PF00651.31 ETO12774.1 - 1.5e-06 28.4 0.1 6.1e-06 26.4 0.0 1.9 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 ETO12774.1 - 0.064 13.4 1.6 0.25 11.5 1.0 2.1 1 1 1 2 2 2 0 BTB And C-terminal Kelch Tubulin_C PF03953.17 ETO12775.1 - 2.1e-41 141.0 0.0 3.3e-41 140.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO12775.1 - 2.9e-33 115.7 0.1 1.1e-32 113.8 0.1 2.0 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ETO12775.1 - 0.00059 19.6 0.0 0.0011 18.7 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 ETO12775.1 - 0.017 14.3 0.0 0.031 13.5 0.0 1.5 1 0 0 1 1 1 0 Tubulin like zf-C3HC4_3 PF13920.6 ETO12776.1 - 6.7e-11 41.9 6.3 1.1e-10 41.2 6.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO12776.1 - 1e-10 41.3 9.4 1.7e-10 40.6 9.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO12776.1 - 1.1e-08 34.8 7.8 1.8e-08 34.1 7.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO12776.1 - 2.4e-08 34.1 8.9 4e-08 33.5 8.9 1.4 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ETO12776.1 - 2e-06 27.5 6.5 3.5e-06 26.8 6.5 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ETO12776.1 - 8.3e-06 25.7 5.3 1.9e-05 24.6 5.3 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO12776.1 - 1.1e-05 25.2 8.3 2e-05 24.5 8.3 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETO12776.1 - 1.9e-05 24.7 9.0 3.7e-05 23.8 9.0 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-rbx1 PF12678.7 ETO12776.1 - 0.00093 19.4 8.3 0.0027 18.0 8.3 1.8 1 1 0 1 1 1 1 RING-H2 zinc finger domain DUF2722 PF10846.8 ETO12776.1 - 0.0032 16.5 8.0 0.0047 15.9 8.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) zf-ANAPC11 PF12861.7 ETO12776.1 - 0.0068 16.4 1.6 0.014 15.4 1.6 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger DZR PF12773.7 ETO12776.1 - 0.012 15.6 6.2 0.16 12.0 6.5 2.1 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_6 PF14835.6 ETO12776.1 - 0.033 14.1 3.6 0.08 12.8 3.6 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Di19 PF05605.12 ETO12776.1 - 0.055 13.8 3.6 1.3 9.4 0.5 2.4 1 1 1 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-UDP PF14569.6 ETO12776.1 - 0.66 10.1 5.5 2.5 8.3 5.5 1.9 1 1 0 1 1 1 0 Zinc-binding RING-finger Spt20 PF12090.8 ETO12776.1 - 0.99 9.0 12.8 2 8.0 12.8 1.5 1 0 0 1 1 1 0 Spt20 family zf-RING_11 PF17123.5 ETO12776.1 - 1.1 9.0 11.1 0.25 11.1 7.2 2.0 2 0 0 2 2 2 0 RING-like zinc finger Peroxin-13_N PF04088.13 ETO12776.1 - 1.3 9.3 3.9 2.3 8.5 0.1 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Presenilin PF01080.17 ETO12776.1 - 1.4 7.6 4.4 2.1 7.0 4.4 1.2 1 0 0 1 1 1 0 Presenilin zf-RING_4 PF14570.6 ETO12776.1 - 2.7 7.9 10.4 30 4.5 10.5 2.2 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Glyco_hydro_3_C PF01915.22 ETO12777.1 - 1.2e-29 103.8 0.0 1.8e-29 103.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ETO12777.1 - 0.01 15.9 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 Fibronectin type III-like domain Maf1 PF09174.10 ETO12778.1 - 0.0061 16.7 1.7 0.009 16.2 1.7 1.3 1 0 0 1 1 1 1 Maf1 regulator DUF3464 PF11947.8 ETO12778.1 - 0.82 9.4 3.4 1.9 8.2 3.4 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Secretin_N_2 PF07655.13 ETO12778.1 - 8.4 7.0 17.0 17 6.0 16.7 1.8 1 1 0 1 1 1 0 Secretin N-terminal domain Cys_rich_KTR PF14205.6 ETO12779.1 - 0.0043 16.8 0.1 0.012 15.3 0.1 1.7 1 0 0 1 1 1 1 Cysteine-rich KTR RRM_1 PF00076.22 ETO12779.1 - 0.015 15.1 0.0 0.05 13.4 0.0 2.0 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) XRN1_D2_D3 PF18334.1 ETO12779.1 - 0.22 11.8 2.5 0.35 11.1 0.0 2.6 3 0 0 3 3 3 0 Exoribonuclease Xrn1 D2/D3 domain zf-RRPl_C4 PF17026.5 ETO12779.1 - 2.9 8.0 13.3 0.13 12.4 0.9 2.9 2 1 0 3 3 3 0 Putative ribonucleoprotein zinc-finger pf C4 type OST-HTH PF12872.7 ETO12780.1 - 3.9e-05 23.4 0.1 7.3e-05 22.5 0.1 1.3 1 0 0 1 1 1 1 OST-HTH/LOTUS domain Transformer PF06495.11 ETO12782.1 - 5.6 7.0 28.8 1.3 9.1 21.9 2.9 3 0 0 3 3 3 0 Fruit fly transformer protein NST1 PF13945.6 ETO12783.1 - 0.029 14.5 7.5 0.029 14.5 7.5 2.0 2 0 0 2 2 2 0 Salt tolerance down-regulator Apc15p PF05841.11 ETO12783.1 - 0.033 15.0 4.8 0.033 15.0 4.8 2.3 2 0 0 2 2 2 0 Apc15p protein Secretin_N_2 PF07655.13 ETO12783.1 - 0.65 10.6 28.6 1 9.9 2.3 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Menin PF05053.13 ETO12783.1 - 2.3 6.5 14.5 1.7 6.9 9.4 2.0 2 0 0 2 2 2 0 Menin GST_N PF02798.20 ETO12784.1 - 4.8e-09 36.4 0.0 7.7e-09 35.8 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain Vps26 PF03643.15 ETO12785.1 - 1.3e-96 322.9 1.7 1.4e-96 322.7 1.7 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ETO12785.1 - 0.00086 19.4 0.7 1.2 9.2 0.0 3.0 2 1 0 3 3 3 2 Arrestin (or S-antigen), N-terminal domain Ion_trans_N PF08412.10 ETO12785.1 - 0.025 14.2 0.0 0.047 13.3 0.0 1.5 1 0 0 1 1 1 0 Ion transport protein N-terminal GTA_holin_3TM PF11351.8 ETO12786.1 - 1.4 9.5 4.4 0.52 10.9 0.2 2.0 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release DUF4551 PF15087.6 ETO12786.1 - 2 7.2 20.4 2.3 7.0 20.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) BSP_II PF05432.11 ETO12786.1 - 2.1 8.0 33.3 3.4 7.3 33.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SURF2 PF05477.11 ETO12786.1 - 2.9 7.5 27.5 4.1 7.0 27.5 1.4 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SRP-alpha_N PF04086.13 ETO12786.1 - 5.3 6.9 31.8 7.5 6.4 31.8 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDK5_activator PF03261.15 ETO12786.1 - 7.4 6.0 25.2 9 5.7 25.2 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein CCDC-167 PF15188.6 ETO12788.1 - 0.13 12.6 5.6 0.33 11.3 1.3 2.7 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Glt_symporter PF03616.14 ETO12789.1 - 0.26 10.0 3.9 0.1 11.3 1.7 1.4 1 1 1 2 2 2 0 Sodium/glutamate symporter Vfa1 PF08432.10 ETO12790.1 - 0.082 13.2 12.9 0.1 12.9 12.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO12790.1 - 0.27 11.0 4.1 0.33 10.7 4.1 1.1 1 0 0 1 1 1 0 Connexin AAA_11 PF13086.6 ETO12790.1 - 0.29 10.9 3.6 0.28 10.9 3.6 1.1 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 ETO12790.1 - 0.31 9.3 10.2 0.37 9.0 10.2 1.0 1 0 0 1 1 1 0 CDC45-like protein MAP17 PF15807.5 ETO12790.1 - 3.9 7.7 8.9 4.9 7.4 8.9 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Auts2 PF15336.6 ETO12790.1 - 5.8 7.0 12.0 7.9 6.5 12.0 1.1 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein LRR_6 PF13516.6 ETO12791.1 - 2.1e-19 67.9 18.0 0.0016 18.3 0.0 7.5 7 0 0 7 7 7 6 Leucine Rich repeat LRR_1 PF00560.33 ETO12791.1 - 9.8e-09 34.6 3.7 12 6.9 0.0 6.8 6 0 0 6 6 6 2 Leucine Rich Repeat LRR_4 PF12799.7 ETO12791.1 - 2.7e-05 24.4 10.0 0.39 11.2 0.5 6.4 6 1 0 6 6 6 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO12791.1 - 0.0012 18.6 13.5 1 9.2 1.2 5.5 5 2 0 5 5 5 3 Leucine rich repeat FAM75 PF14650.6 ETO12793.1 - 0.19 11.2 2.7 0.43 10.1 2.7 1.5 1 0 0 1 1 1 0 FAM75 family DUF1463 PF07316.11 ETO12794.1 - 0.048 13.5 0.3 0.16 11.8 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1463) Asp4 PF16996.5 ETO12794.1 - 0.26 11.1 0.0 0.26 11.1 0.0 2.4 3 0 0 3 3 3 0 Accessory secretory protein Sec Asp4 Methyltransf_21 PF05050.12 ETO12795.1 - 4.3e-10 39.9 0.0 3.6e-09 36.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase FkbM domain SMODS PF18144.1 ETO12795.1 - 0.037 14.2 0.0 0.072 13.2 0.0 1.4 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain YMF19 PF02326.15 ETO12796.1 - 0.043 14.6 1.6 0.088 13.6 1.6 1.4 1 0 0 1 1 1 0 Plant ATP synthase F0 DUF2207 PF09972.9 ETO12796.1 - 2.3 6.9 4.3 2.6 6.7 4.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Ras PF00071.22 ETO12797.1 - 1e-12 48.0 1.3 7.4e-05 22.4 0.1 4.1 3 1 0 3 3 3 3 Ras family Roc PF08477.13 ETO12797.1 - 6.6e-05 23.1 6.9 0.00013 22.2 0.1 3.6 3 1 1 4 4 4 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO12797.1 - 0.0038 16.7 0.1 8 5.9 0.0 3.7 4 0 0 4 4 4 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO12797.1 - 0.056 12.8 1.4 0.62 9.4 0.1 2.5 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region PilP PF04351.13 ETO12797.1 - 0.27 11.2 4.6 12 5.8 1.3 2.7 2 0 0 2 2 2 0 Pilus assembly protein, PilP DUF3439 PF11921.8 ETO12797.1 - 9.2 6.3 18.8 2.2 8.3 14.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) MFS_1 PF07690.16 ETO12798.1 - 9.9e-07 28.0 5.4 9.9e-07 28.0 5.4 1.6 2 0 0 2 2 2 1 Major Facilitator Superfamily ubiquitin PF00240.23 ETO12799.1 - 5.6e-33 112.5 0.7 9.3e-33 111.8 0.3 1.5 2 0 0 2 2 2 1 Ubiquitin family Ribosomal_S27 PF01599.19 ETO12799.1 - 1.4e-20 73.1 4.2 2.7e-20 72.3 4.2 1.5 1 0 0 1 1 1 1 Ribosomal protein S27a Rad60-SLD PF11976.8 ETO12799.1 - 4e-15 55.4 0.3 6.6e-15 54.7 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO12799.1 - 1.2e-05 25.6 0.1 7.6e-05 23.1 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO12799.1 - 0.0004 20.5 0.4 0.00088 19.4 0.4 1.6 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO12799.1 - 0.00074 20.0 0.2 0.0012 19.4 0.2 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ETO12799.1 - 0.0019 18.1 0.0 0.0033 17.3 0.0 1.4 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO12799.1 - 0.0048 17.2 0.0 0.01 16.2 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO12799.1 - 0.16 12.0 0.5 11 6.1 0.0 2.4 1 1 1 2 2 2 0 Ubiquitin-like domain AAA_12 PF13087.6 ETO12800.1 - 5.3e-57 192.7 0.0 8e-57 192.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETO12800.1 - 1.8e-26 93.5 0.3 4.9e-17 62.6 0.1 2.4 1 1 1 2 2 2 2 AAA domain AAA_30 PF13604.6 ETO12800.1 - 1.3e-06 28.3 0.0 2.6e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETO12800.1 - 9.9e-06 26.0 0.0 2.7e-05 24.6 0.0 1.7 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ETO12800.1 - 0.0037 17.0 0.0 2.3 7.9 0.0 2.2 2 0 0 2 2 2 2 Viral (Superfamily 1) RNA helicase Packaging_FI PF14000.6 ETO12801.1 - 0.0091 16.5 0.8 0.011 16.2 0.8 1.2 1 0 0 1 1 1 1 DNA packaging protein FI Zip PF02535.22 ETO12801.1 - 2.4 7.3 4.8 2.2 7.4 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Folate_carrier PF01770.18 ETO12801.1 - 2.6 6.7 4.7 3 6.5 4.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier Presenilin PF01080.17 ETO12801.1 - 3.5 6.3 6.4 3.3 6.4 6.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETO12801.1 - 7.2 7.7 6.9 11 7.0 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TPR_12 PF13424.6 ETO12802.1 - 1.3e-62 208.0 14.9 8.8e-17 61.2 1.5 4.5 1 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12802.1 - 2.1e-43 145.0 2.2 8.4e-10 38.2 0.0 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12802.1 - 1e-38 129.6 32.4 2.3e-08 33.5 0.2 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12802.1 - 6.3e-37 122.9 5.5 3.8e-06 26.6 0.1 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12802.1 - 1.9e-33 111.8 30.1 4e-07 29.7 0.3 6.9 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12802.1 - 5.3e-25 85.5 23.1 1.5e-05 24.7 0.1 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12802.1 - 6.7e-13 48.0 16.9 0.0019 18.5 0.1 6.6 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO12802.1 - 3.1e-11 42.8 29.8 0.0088 15.7 0.8 9.3 7 3 3 10 10 10 4 TPR repeat DUF5113 PF17140.4 ETO12802.1 - 1.1e-08 35.0 21.1 0.035 13.9 0.3 6.0 2 2 3 5 5 5 3 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO12802.1 - 4.7e-08 33.2 0.0 5.3 8.1 0.0 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO12802.1 - 1.1e-07 32.0 2.8 2.6 8.9 0.0 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12802.1 - 2.3e-07 31.4 0.0 1 10.0 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO12802.1 - 3.7e-07 29.8 0.0 0.00068 19.1 0.0 2.3 1 1 2 3 3 3 2 MalT-like TPR region MIT PF04212.18 ETO12802.1 - 7.7e-06 25.9 18.8 0.42 10.7 0.0 6.2 5 1 1 6 6 6 2 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO12802.1 - 0.00017 21.4 21.1 0.73 9.5 1.4 5.1 3 1 1 4 4 4 2 Uncharacterized protein conserved in bacteria (DUF2225) RPN7 PF10602.9 ETO12802.1 - 0.00021 21.0 7.4 0.16 11.6 0.3 4.3 2 1 2 4 4 4 1 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 ETO12802.1 - 0.0019 17.6 0.1 7.1 6.2 0.0 4.1 4 0 0 4 4 4 1 SHNi-TPR NRBF2_MIT PF17169.4 ETO12802.1 - 0.0024 18.0 2.1 15 5.9 0.0 3.7 3 0 0 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 Kelch_5 PF13854.6 ETO12802.1 - 0.053 13.5 1.4 8.7 6.5 0.1 4.2 5 0 0 5 5 4 0 Kelch motif DUF3856 PF12968.7 ETO12802.1 - 0.11 12.5 1.6 3.7 7.6 0.3 3.2 2 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) PPR PF01535.20 ETO12802.1 - 0.12 12.7 10.2 0.72 10.2 0.0 5.5 6 0 0 6 6 6 0 PPR repeat DUF627 PF04781.12 ETO12802.1 - 0.18 11.8 2.7 13 5.9 0.1 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF627) Kelch_1 PF01344.25 ETO12802.1 - 1.8 8.2 4.8 24 4.6 0.0 3.7 4 0 0 4 4 4 0 Kelch motif SMI1_KNR4 PF09346.10 ETO12802.1 - 3.4 8.1 15.9 0.027 14.9 2.7 3.5 2 1 0 3 3 2 0 SMI1 / KNR4 family (SUKH-1) DUF3421 PF11901.8 ETO12803.1 - 0.016 15.2 0.1 0.033 14.2 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3421) CDH1_2_SANT_HL1 PF18375.1 ETO12804.1 - 0.0076 16.9 0.1 0.012 16.3 0.1 1.3 1 0 0 1 1 1 1 CDH1/2 SANT-Helical linker 1 RLL PF10036.9 ETO12804.1 - 0.037 13.9 0.1 0.039 13.8 0.1 1.2 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein PfaD_N PF18328.1 ETO12804.1 - 0.071 13.1 0.1 0.15 12.0 0.1 1.5 1 0 0 1 1 1 0 Fatty acid synthase subunit PfaD N-terminal domain EPL1 PF10513.9 ETO12806.1 - 0.0036 17.7 0.4 0.0049 17.3 0.4 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like Tubulin PF00091.25 ETO12807.1 - 2.7e-46 158.3 0.5 2.2e-22 80.2 0.3 2.1 1 1 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 ETO12807.1 - 8.8e-06 26.0 0.0 1.8e-05 25.0 0.0 1.7 1 1 0 1 1 1 1 Misato Segment II tubulin-like domain DBP10CT PF08147.12 ETO12807.1 - 0.23 11.8 0.4 0.23 11.8 0.4 2.0 2 0 0 2 2 2 0 DBP10CT (NUC160) domain Tubulin PF00091.25 ETO12808.1 - 2.1e-09 37.8 0.2 2.8e-09 37.5 0.2 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO12808.1 - 0.0034 17.5 0.5 0.0082 16.3 0.1 1.9 2 1 0 2 2 2 1 Tubulin C-terminal domain TraS PF10624.9 ETO12808.1 - 0.11 12.4 0.0 0.14 12.1 0.0 1.2 1 0 0 1 1 1 0 Plasmid conjugative transfer entry exclusion protein TraS TRADD_N PF09034.10 ETO12810.1 - 0.053 13.6 0.3 0.2 11.7 0.3 2.0 1 0 0 1 1 1 0 TRADD, N-terminal domain DUF3112 PF11309.8 ETO12810.1 - 0.48 9.8 4.5 0.65 9.4 1.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) Red1 PF07964.11 ETO12811.1 - 0.84 7.8 16.1 1.2 7.3 16.1 1.1 1 0 0 1 1 1 0 Rec10 / Red1 MAGE_N PF12440.8 ETO12812.1 - 0.012 16.3 5.5 0.012 16.3 5.5 2.3 2 0 0 2 2 2 0 Melanoma associated antigen family N terminal Trypan_PARP PF05887.11 ETO12812.1 - 0.013 15.5 7.3 0.013 15.5 7.3 2.1 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SLC12 PF03522.15 ETO12812.1 - 6 5.8 9.9 7.2 5.5 3.4 2.1 2 0 0 2 2 2 0 Solute carrier family 12 cNMP_binding PF00027.29 ETO12813.1 - 1.8e-33 114.5 0.1 3.7e-15 55.7 0.0 3.5 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Hema_stalk PF08720.10 ETO12813.1 - 0.0044 16.7 0.4 0.0087 15.8 0.4 1.5 1 0 0 1 1 1 1 Influenza C hemagglutinin stalk Pkinase PF00069.25 ETO12813.1 - 0.041 13.3 0.6 0.041 13.3 0.6 2.0 2 0 0 2 2 2 0 Protein kinase domain HA2 PF04408.23 ETO12814.1 - 1.5 9.2 6.9 2.5 8.4 0.7 3.0 3 0 0 3 3 3 0 Helicase associated domain (HA2) DUF3915 PF13054.6 ETO12814.1 - 1.9 8.5 6.0 0.57 10.2 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) FTCD_C PF04961.12 ETO12815.1 - 0.0078 16.0 0.7 0.013 15.3 0.7 1.2 1 0 0 1 1 1 1 Formiminotransferase-cyclodeaminase SR-25 PF10500.9 ETO12815.1 - 0.0082 15.8 12.1 0.012 15.3 12.1 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Chorion_3 PF05387.11 ETO12815.1 - 0.5 10.0 8.2 0.77 9.4 8.2 1.2 1 0 0 1 1 1 0 Chorion family 3 Macoilin PF09726.9 ETO12815.1 - 0.53 8.8 6.9 0.55 8.7 6.9 1.0 1 0 0 1 1 1 0 Macoilin family DUF755 PF05501.11 ETO12815.1 - 2.5 8.4 18.5 0.13 12.6 13.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF755) IMUP PF15761.5 ETO12815.1 - 2.6 8.8 20.9 1 10.1 18.3 1.7 1 1 1 2 2 2 0 Immortalisation up-regulated protein MtrF PF09472.10 ETO12817.1 - 0.012 15.0 0.2 0.027 13.8 0.2 1.6 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) dsrm PF00035.26 ETO12818.1 - 0.005 17.5 0.4 0.022 15.4 0.0 2.2 2 0 0 2 2 2 1 Double-stranded RNA binding motif VPS11_C PF12451.8 ETO12818.1 - 0.012 15.9 0.3 0.064 13.5 0.0 2.2 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal Peptidase_C48 PF02902.19 ETO12819.1 - 4.4e-12 46.3 0.6 1.4e-11 44.6 0.4 2.1 1 1 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain MKT1_C PF12246.8 ETO12820.1 - 3.7e-16 59.1 0.2 6.5e-16 58.3 0.2 1.4 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication Utp21 PF04192.12 ETO12820.1 - 0.04 13.4 2.1 0.18 11.3 0.7 2.5 3 0 0 3 3 3 0 Utp21 specific WD40 associated putative domain MKT1_N PF12247.8 ETO12821.1 - 8.3e-07 29.3 0.0 1.7e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Temperature dependent protein affecting M2 dsRNA replication AAA_2 PF07724.14 ETO12823.1 - 4.3e-24 85.5 0.0 4.9e-24 85.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 ETO12823.1 - 5.7e-07 30.0 0.0 6.7e-07 29.8 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) DUF5083 PF16890.5 ETO12824.1 - 2.6 7.8 9.4 0.5 10.1 3.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5083) DHHC PF01529.20 ETO12824.1 - 7.3 6.7 25.4 0.96 9.6 1.3 3.3 2 1 1 3 3 3 0 DHHC palmitoyltransferase IMUP PF15761.5 ETO12826.1 - 0.0053 17.4 7.2 0.012 16.3 7.2 1.5 1 0 0 1 1 1 1 Immortalisation up-regulated protein TFIIA PF03153.13 ETO12826.1 - 0.0056 16.7 13.8 0.0066 16.5 13.8 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Hydin_ADK PF17213.3 ETO12826.1 - 0.03 14.6 7.3 0.043 14.1 7.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SR-25 PF10500.9 ETO12826.1 - 0.84 9.2 15.2 0.92 9.1 14.8 1.3 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Lin-8 PF03353.15 ETO12826.1 - 1.5 8.3 12.0 1.9 8.0 12.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Spt20 PF12090.8 ETO12826.1 - 1.6 8.3 17.5 2.4 7.7 17.5 1.2 1 0 0 1 1 1 0 Spt20 family GREB1 PF15782.5 ETO12826.1 - 2 5.4 13.2 2.5 5.1 13.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer E_Pc_C PF06752.12 ETO12826.1 - 2.4 8.2 21.9 0.3 11.2 14.3 2.1 2 0 0 2 2 2 0 Enhancer of Polycomb C-terminus RNase_HII PF01351.18 ETO12828.1 - 1.4e-28 100.1 0.1 5.1e-27 95.0 0.1 2.3 1 1 0 1 1 1 1 Ribonuclease HII Citrate_synt PF00285.21 ETO12829.1 - 6.2e-92 308.4 0.0 7.9e-92 308.1 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain Ribosomal_L30_N PF08079.12 ETO12830.1 - 0.0075 16.5 12.8 0.0075 16.5 12.8 3.2 2 1 1 3 3 3 1 Ribosomal L30 N-terminal domain SID-1_RNA_chan PF13965.6 ETO12830.1 - 0.047 12.1 6.1 0.059 11.8 6.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Menin PF05053.13 ETO12830.1 - 0.063 11.6 4.9 0.071 11.5 4.9 1.0 1 0 0 1 1 1 0 Menin FRG1 PF06229.12 ETO12830.1 - 0.55 9.9 14.5 0.017 14.9 4.2 2.0 2 0 0 2 2 2 0 FRG1-like domain BatD PF13584.6 ETO12830.1 - 2.2 7.0 10.3 2.9 6.6 10.1 1.3 1 1 0 1 1 1 0 Oxygen tolerance Ribosomal_L30 PF00327.20 ETO12831.1 - 1.9e-15 56.5 3.9 3.6e-15 55.6 1.6 2.2 2 0 0 2 2 2 1 Ribosomal protein L30p/L7e NIF PF03031.18 ETO12832.1 - 1.2e-08 34.9 0.2 1.6e-07 31.2 0.0 2.3 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase RunxI PF08504.11 ETO12832.1 - 2.8 8.7 6.9 1 10.1 3.5 2.0 2 0 0 2 2 2 0 Runx inhibition domain DUF4637 PF15470.6 ETO12833.1 - 1.4 8.6 5.7 3.4 7.4 5.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pox_EPC_I2-L1 PF12575.8 ETO12835.1 - 0.0047 17.1 0.5 0.0089 16.2 0.5 1.4 1 0 0 1 1 1 1 Poxvirus entry protein complex L1 and I2 WD40 PF00400.32 ETO12836.1 - 1.4e-107 348.5 51.1 1.2e-09 38.6 0.9 16.6 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12836.1 - 1.3e-25 89.5 19.2 0.006 16.8 0.0 13.1 1 1 13 14 14 14 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12836.1 - 6.2e-13 48.4 9.4 0.5 9.3 0.0 10.4 2 2 8 12 12 12 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO12836.1 - 2.8e-08 33.5 11.5 0.01 15.8 0.0 9.2 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO12836.1 - 2.6e-07 30.1 1.9 5.5e-07 29.1 1.9 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PQQ_2 PF13360.6 ETO12836.1 - 1.3e-05 24.9 4.0 0.0057 16.3 0.1 4.2 2 2 2 4 4 4 2 PQQ-like domain Mid2 PF04478.12 ETO12836.1 - 0.00011 22.1 6.1 0.57 10.0 0.1 6.3 4 2 3 7 7 7 1 Mid2 like cell wall stress sensor Pentapeptide_4 PF13599.6 ETO12836.1 - 0.00033 20.7 0.1 0.00082 19.5 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Str_synth PF03088.16 ETO12836.1 - 0.0007 19.7 2.7 15 5.8 0.0 6.4 7 1 2 9 9 8 0 Strictosidine synthase Pentapeptide_3 PF13576.6 ETO12836.1 - 0.0021 18.1 0.8 0.0048 17.0 0.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5319 PF17252.2 ETO12836.1 - 0.041 14.1 0.0 39 4.5 0.0 3.9 4 1 1 5 5 5 0 Family of unknown function (DUF5319) DUF1938 PF09153.10 ETO12836.1 - 0.095 12.8 0.1 3.5 7.8 0.1 3.2 3 0 0 3 3 2 0 Domain of unknown function (DUF1938) Proteasome_A_N PF10584.9 ETO12836.1 - 0.11 12.2 1.6 1.1e+02 2.6 0.0 4.9 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature S-l_SbsC_C PF18316.1 ETO12836.1 - 0.26 11.8 1.7 1e+02 3.5 0.0 5.6 5 2 2 7 7 6 0 S-layer protein SbsC C-terminal domain DUF5418 PF17439.2 ETO12837.1 - 0.048 13.8 0.0 0.049 13.7 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5418) BCS1_N PF08740.11 ETO12839.1 - 3.1e-16 59.9 0.7 5.5e-16 59.1 0.0 1.7 2 0 0 2 2 2 1 BCS1 N terminal AAA PF00004.29 ETO12839.1 - 1.4e-13 51.5 0.0 3.6e-11 43.6 0.0 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO12839.1 - 0.0016 18.8 0.5 0.0035 17.8 0.0 1.9 2 1 0 2 2 1 1 AAA ATPase domain Pex14_N PF04695.13 ETO12839.1 - 0.0024 18.5 0.9 0.011 16.4 0.2 2.0 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region AAA_25 PF13481.6 ETO12839.1 - 0.0034 17.0 0.0 0.0074 15.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO12839.1 - 0.0084 16.1 0.0 0.056 13.4 0.0 2.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_29 PF13555.6 ETO12839.1 - 0.024 14.4 0.0 0.05 13.3 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase PF06745.13 ETO12839.1 - 0.035 13.4 0.0 0.07 12.5 0.0 1.4 1 0 0 1 1 1 0 KaiC DUF815 PF05673.13 ETO12839.1 - 0.037 13.2 0.0 0.059 12.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) RNA_helicase PF00910.22 ETO12839.1 - 0.065 13.6 0.0 0.16 12.3 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 ETO12839.1 - 0.12 12.9 0.0 0.3 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETO12839.1 - 0.25 11.0 1.4 0.27 10.9 0.0 1.8 2 0 0 2 2 2 0 AAA domain Bromodomain PF00439.25 ETO12840.1 - 2.2e-05 24.5 0.5 6.3e-05 23.0 0.5 1.8 1 0 0 1 1 1 1 Bromodomain SR-25 PF10500.9 ETO12840.1 - 0.00017 21.3 2.8 0.00017 21.3 2.8 3.4 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein GHMP_kinases_N PF00288.26 ETO12840.1 - 0.15 12.3 9.0 0.36 11.1 0.3 3.4 3 0 0 3 3 3 0 GHMP kinases N terminal domain MCR_alpha PF02249.17 ETO12840.1 - 0.61 10.5 6.5 0.22 12.0 0.3 2.6 3 0 0 3 3 3 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain RAP1 PF07218.11 ETO12840.1 - 8.9 4.4 19.0 0.071 11.4 0.5 2.5 3 0 0 3 3 3 0 Rhoptry-associated protein 1 (RAP-1) PH PF00169.29 ETO12841.1 - 4e-05 24.1 0.5 7.7e-05 23.2 0.5 1.7 1 1 0 1 1 1 1 PH domain zf-C2H2 PF00096.26 ETO12842.1 - 0.0017 18.7 15.0 1.5 9.5 1.3 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ETO12842.1 - 0.025 14.9 2.8 0.074 13.4 0.9 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ETO12842.1 - 0.11 12.2 1.0 0.41 10.4 1.0 2.0 1 0 0 1 1 1 0 C2H2-type zinc-finger domain zf-C2H2_4 PF13894.6 ETO12842.1 - 0.55 11.2 13.4 0.57 11.2 1.0 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger Syntaxin-6_N PF09177.11 ETO12843.1 - 2.7e-14 53.5 2.8 2.7e-14 53.5 2.8 2.9 2 2 0 2 2 2 1 Syntaxin 6, N-terminal SNARE PF05739.19 ETO12843.1 - 0.00035 20.5 1.9 0.00035 20.5 1.9 3.3 3 0 0 3 3 3 1 SNARE domain Laminin_II PF06009.12 ETO12843.1 - 0.011 15.8 18.5 0.091 12.8 3.2 3.0 1 1 2 3 3 3 0 Laminin Domain II PfUIS3 PF11567.8 ETO12843.1 - 0.034 14.5 0.8 0.034 14.5 0.8 2.7 1 1 1 3 3 3 0 Plasmodium falciparum UIS3 membrane protein DUF4298 PF14131.6 ETO12843.1 - 0.063 13.2 0.3 0.063 13.2 0.3 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4298) Use1 PF09753.9 ETO12843.1 - 0.11 12.2 25.7 0.33 10.6 25.7 1.8 1 1 0 1 1 1 0 Membrane fusion protein Use1 ALMT PF11744.8 ETO12843.1 - 0.3 9.9 16.4 0.38 9.5 16.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1967 PF09269.11 ETO12843.1 - 0.44 10.5 6.2 0.92 9.5 0.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1967) DUF4407 PF14362.6 ETO12843.1 - 0.46 9.8 22.1 69 2.6 22.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0184 PF03670.13 ETO12843.1 - 0.53 10.7 5.7 0.91 10.0 0.4 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) IL11 PF07400.11 ETO12843.1 - 2.4 7.8 10.0 0.43 10.2 0.4 3.0 2 1 1 3 3 3 0 Interleukin 11 DUF1664 PF07889.12 ETO12843.1 - 4.6 7.3 24.0 0.49 10.4 4.8 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) KxDL PF10241.9 ETO12843.1 - 6.5 7.1 24.6 0.38 11.1 4.8 4.1 2 2 1 3 3 3 0 Uncharacterized conserved protein WXG100 PF06013.12 ETO12843.1 - 9.5 6.5 20.4 1.6 9.0 2.8 4.2 3 2 0 3 3 3 0 Proteins of 100 residues with WXG TipE PF16972.5 ETO12844.1 - 0.0063 15.7 10.5 0.0083 15.4 10.5 1.2 1 0 0 1 1 1 1 Na+ channel auxiliary subunit TipE PRKCSH PF07915.13 ETO12845.1 - 0.017 16.1 2.5 0.017 16.1 2.5 2.4 2 1 0 2 2 2 0 Glucosidase II beta subunit-like protein DUF1765 PF08578.10 ETO12846.1 - 0.022 15.2 8.6 0.051 14.0 1.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1765) PSD1 PF07587.11 ETO12846.1 - 0.027 14.0 0.0 0.05 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1553) Peptidase_M1 PF01433.20 ETO12847.1 - 5.8e-29 101.2 0.5 5.9e-17 62.0 0.0 2.5 3 0 0 3 3 3 2 Peptidase family M1 domain Peptidase_M61 PF05299.12 ETO12847.1 - 0.22 12.0 2.1 23 5.4 2.1 2.5 1 1 0 1 1 1 0 M61 glycyl aminopeptidase Peptidase_M1_N PF17900.1 ETO12848.1 - 7.9e-22 78.3 0.1 9.9e-22 78.0 0.1 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain LRR_adjacent PF08191.11 ETO12848.1 - 0.11 12.7 0.4 7.5 6.8 0.1 3.0 3 0 0 3 3 3 0 LRR adjacent DUF1664 PF07889.12 ETO12849.1 - 0.00069 19.7 6.8 0.00069 19.7 6.8 5.8 4 2 3 7 7 7 2 Protein of unknown function (DUF1664) GIT_CC PF16559.5 ETO12849.1 - 1.2 9.1 64.4 0.082 12.8 2.5 9.6 6 4 3 9 9 9 0 GIT coiled-coil Rho guanine nucleotide exchange factor Spc7 PF08317.11 ETO12850.1 - 0.00042 19.3 7.1 0.00042 19.3 7.1 1.5 2 0 0 2 2 2 1 Spc7 kinetochore protein FlaC_arch PF05377.11 ETO12850.1 - 0.00059 20.2 2.5 0.59 10.6 0.7 2.8 1 1 1 2 2 2 2 Flagella accessory protein C (FlaC) DUF2205 PF10224.9 ETO12850.1 - 0.0023 17.9 1.0 0.0054 16.7 1.0 1.8 1 0 0 1 1 1 1 Short coiled-coil protein DUF3958 PF13125.6 ETO12850.1 - 0.0023 18.1 6.9 0.0047 17.1 6.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3958) FliJ PF02050.16 ETO12850.1 - 0.0033 17.6 8.9 0.052 13.8 2.9 2.2 1 1 1 2 2 2 1 Flagellar FliJ protein APG6_N PF17675.1 ETO12850.1 - 0.0035 17.9 6.8 0.0079 16.7 6.8 1.5 1 1 0 1 1 1 1 Apg6 coiled-coil region PspA_IM30 PF04012.12 ETO12850.1 - 0.0048 16.5 6.1 0.0079 15.8 6.1 1.3 1 0 0 1 1 1 1 PspA/IM30 family MscS_porin PF12795.7 ETO12850.1 - 0.0077 15.8 2.2 0.027 14.0 2.2 1.8 1 1 0 1 1 1 1 Mechanosensitive ion channel porin domain Noelin-1 PF12308.8 ETO12850.1 - 0.0079 16.2 2.9 0.71 9.9 0.1 2.8 1 1 2 3 3 3 1 Neurogenesis glycoprotein DUF4140 PF13600.6 ETO12850.1 - 0.01 16.3 1.6 3.1 8.3 0.1 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF1664 PF07889.12 ETO12850.1 - 0.012 15.6 4.9 0.082 12.9 2.6 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Filament PF00038.21 ETO12850.1 - 0.014 14.9 8.2 0.02 14.5 7.4 1.4 1 1 0 1 1 1 0 Intermediate filament protein UPF0242 PF06785.11 ETO12850.1 - 0.015 15.4 9.7 0.022 14.9 9.7 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Fib_alpha PF08702.10 ETO12850.1 - 0.028 14.6 7.6 0.04 14.1 6.6 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DHR10 PF18595.1 ETO12850.1 - 0.038 14.1 8.1 0.13 12.3 2.4 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF5082 PF16888.5 ETO12850.1 - 0.038 14.3 7.0 0.24 11.7 7.0 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) COG5 PF10392.9 ETO12850.1 - 0.042 14.0 1.0 0.13 12.4 0.3 2.0 1 1 0 2 2 2 0 Golgi transport complex subunit 5 Flagellin_C PF00700.21 ETO12850.1 - 0.057 13.8 4.0 4.6 7.7 0.0 3.2 3 0 0 3 3 3 0 Bacterial flagellin C-terminal helical region TPR_MLP1_2 PF07926.12 ETO12850.1 - 0.066 13.3 8.2 1.5 8.8 1.4 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein THOC7 PF05615.13 ETO12850.1 - 0.076 13.3 7.7 0.2 12.0 7.7 1.5 1 1 0 1 1 1 0 Tho complex subunit 7 Lebercilin PF15619.6 ETO12850.1 - 0.14 11.8 8.7 0.33 10.6 8.9 1.5 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease HIP1_clath_bdg PF16515.5 ETO12850.1 - 0.16 12.6 8.1 0.78 10.4 7.8 2.2 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-F_leu_zip PF10473.9 ETO12850.1 - 0.17 11.9 9.1 0.66 10.0 9.1 1.9 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2730 PF10805.8 ETO12850.1 - 0.17 12.0 3.1 1 9.5 1.4 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Tropomyosin_1 PF12718.7 ETO12850.1 - 0.22 11.7 8.0 4.9 7.3 2.1 2.2 1 1 1 2 2 2 0 Tropomyosin like CREPT PF16566.5 ETO12850.1 - 0.24 11.6 4.5 0.38 10.9 4.5 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.8 ETO12850.1 - 0.32 11.1 8.2 1.5 8.9 3.1 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding SlyX PF04102.12 ETO12850.1 - 0.35 11.5 3.0 7.7 7.2 0.3 2.8 1 1 1 2 2 2 0 SlyX KASH_CCD PF14662.6 ETO12850.1 - 0.35 10.7 10.0 0.32 10.8 6.2 1.7 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH CENP-Q PF13094.6 ETO12850.1 - 0.4 10.9 5.9 14 5.9 5.8 2.2 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit FlxA PF14282.6 ETO12850.1 - 0.42 10.6 6.8 0.085 12.9 1.9 2.2 1 1 0 2 2 2 0 FlxA-like protein STAT_alpha PF01017.20 ETO12850.1 - 0.44 10.4 9.6 48 3.8 9.6 2.3 1 1 0 1 1 1 0 STAT protein, all-alpha domain zf-C4H2 PF10146.9 ETO12850.1 - 0.48 10.7 8.3 0.72 10.1 8.3 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein Occludin_ELL PF07303.13 ETO12850.1 - 0.73 10.6 8.3 2.9 8.7 1.4 2.3 1 1 1 2 2 2 0 Occludin homology domain TMPIT PF07851.13 ETO12850.1 - 0.81 8.9 7.4 0.44 9.7 5.4 1.5 1 1 0 1 1 1 0 TMPIT-like protein Exonuc_VII_L PF02601.15 ETO12850.1 - 0.84 9.1 6.8 1.3 8.5 6.8 1.4 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF16 PF01519.16 ETO12850.1 - 0.84 10.1 9.7 3 8.4 5.3 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 BRE1 PF08647.11 ETO12850.1 - 0.85 9.7 12.3 1.9 8.6 0.9 3.1 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase AATF-Che1 PF13339.6 ETO12850.1 - 1.5 9.5 7.7 0.55 10.9 0.5 2.6 1 1 2 3 3 2 0 Apoptosis antagonizing transcription factor DUF4200 PF13863.6 ETO12850.1 - 1.6 9.1 14.2 4.2 7.8 14.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) TMF_DNA_bd PF12329.8 ETO12850.1 - 1.8 8.6 9.4 8.1 6.5 2.2 2.6 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding DivIC PF04977.15 ETO12850.1 - 2.1 8.2 6.4 1.7 8.5 1.5 2.5 2 0 0 2 2 2 0 Septum formation initiator CENP-B_dimeris PF09026.10 ETO12851.1 - 0.0026 18.1 2.4 0.38 11.2 0.2 3.5 3 0 0 3 3 3 1 Centromere protein B dimerisation domain CARD PF00619.21 ETO12851.1 - 0.7 10.0 3.9 1.8 8.7 0.9 2.7 2 0 0 2 2 2 0 Caspase recruitment domain DUF4271 PF14093.6 ETO12851.1 - 1.1 9.2 7.2 0.86 9.5 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4271) Utp14 PF04615.13 ETO12853.1 - 0.51 8.9 32.7 0.61 8.6 32.7 1.1 1 0 0 1 1 1 0 Utp14 protein LAP1C PF05609.12 ETO12853.1 - 0.85 8.6 24.5 1.2 8.2 24.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LMBR1 PF04791.16 ETO12853.1 - 1 8.2 11.1 1.1 8.1 11.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Dapper PF15268.6 ETO12853.1 - 1.1 8.1 21.0 1.2 7.9 21.0 1.1 1 0 0 1 1 1 0 Dapper CDC45 PF02724.14 ETO12853.1 - 1.1 7.4 24.8 2.1 6.5 24.8 1.5 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 ETO12853.1 - 1.4 8.5 49.4 2.4 7.8 49.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2981 PF11200.8 ETO12853.1 - 2.7 7.6 16.0 3.5 7.3 16.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) eIF-3c_N PF05470.12 ETO12853.1 - 4.3 5.5 23.1 6.1 5.0 23.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PI3K_1B_p101 PF10486.9 ETO12853.1 - 9.4 3.9 12.9 11 3.7 12.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NUDIX PF00293.28 ETO12854.1 - 5.7e-13 49.0 0.2 1.2e-12 48.0 0.2 1.6 1 0 0 1 1 1 1 NUDIX domain Beta-lactamase PF00144.24 ETO12854.1 - 1.7e-09 37.4 0.0 2.6e-09 36.8 0.0 1.2 1 0 0 1 1 1 1 Beta-lactamase YqaJ PF09588.10 ETO12854.1 - 0.093 12.9 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain LAP1C PF05609.12 ETO12856.1 - 0.0041 16.3 15.2 0.0038 16.4 14.3 1.3 1 1 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF3736 PF12540.8 ETO12856.1 - 0.046 13.8 0.6 0.046 13.8 0.6 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3736) PI3K_1B_p101 PF10486.9 ETO12856.1 - 0.5 8.1 13.7 0.58 7.9 13.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Nop14 PF04147.12 ETO12856.1 - 1.3 7.1 33.4 1.9 6.6 33.4 1.2 1 0 0 1 1 1 0 Nop14-like family polyprenyl_synt PF00348.17 ETO12857.1 - 1.7e-62 210.8 2.3 3e-62 210.0 2.3 1.3 1 0 0 1 1 1 1 Polyprenyl synthetase SAM_1 PF00536.30 ETO12858.1 - 0.001 19.5 0.1 1.3 9.5 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO12858.1 - 0.0087 16.2 0.1 5.8 7.1 0.0 2.3 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) DRMBL PF07522.14 ETO12858.1 - 0.045 13.9 0.2 0.12 12.5 0.2 1.7 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase SAM_PNT PF02198.16 ETO12858.1 - 0.1 12.6 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain TMEM154 PF15102.6 ETO12860.1 - 0.00023 21.1 0.7 0.00023 21.1 0.7 2.3 2 1 1 3 3 3 1 TMEM154 protein family Sigma_reg_N PF13800.6 ETO12860.1 - 0.0015 18.8 4.5 0.0055 17.0 4.5 1.9 1 0 0 1 1 1 1 Sigma factor regulator N-terminal DUF4448 PF14610.6 ETO12860.1 - 0.0022 17.8 0.3 0.0057 16.5 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF2615 PF11027.8 ETO12860.1 - 0.0024 18.0 0.4 0.0079 16.3 0.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) RIFIN PF02009.16 ETO12860.1 - 0.0099 15.8 5.2 0.0099 15.8 5.2 1.9 2 0 0 2 2 2 1 Rifin Pox_EPC_I2-L1 PF12575.8 ETO12860.1 - 0.037 14.3 0.8 0.089 13.0 0.8 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 PQQ_3 PF13570.6 ETO12860.1 - 0.042 14.4 0.0 2.6 8.6 0.0 2.6 2 0 0 2 2 2 0 PQQ-like domain EphA2_TM PF14575.6 ETO12860.1 - 0.05 14.5 1.8 0.071 14.0 0.1 2.1 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain DUF3139 PF11337.8 ETO12860.1 - 0.089 13.5 8.1 0.11 13.2 5.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) PspB PF06667.12 ETO12860.1 - 0.12 12.4 0.2 0.12 12.4 0.2 2.5 3 0 0 3 3 3 0 Phage shock protein B DUF3112 PF11309.8 ETO12860.1 - 0.24 10.8 4.2 0.19 11.1 2.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3112) DUF5383 PF17355.2 ETO12860.1 - 0.99 9.8 13.0 0.34 11.3 0.6 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5383) CSG2 PF16965.5 ETO12860.1 - 1.1 8.2 11.6 0.048 12.6 2.0 2.2 1 1 1 2 2 2 0 Ceramide synthase regulator ATP-synt_8 PF00895.20 ETO12860.1 - 2.9 8.4 8.9 1.8 9.1 4.6 3.0 2 0 0 2 2 2 0 ATP synthase protein 8 BAR_3 PF16746.5 ETO12862.1 - 0.0016 18.2 1.1 0.0016 18.2 1.1 1.6 1 1 0 1 1 1 1 BAR domain of APPL family DUF1256 PF06866.11 ETO12862.1 - 0.025 14.0 0.0 0.035 13.5 0.0 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1256) DUF3539 PF12058.8 ETO12862.1 - 0.056 13.6 0.5 0.096 12.8 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) Stathmin PF00836.19 ETO12862.1 - 0.22 11.5 4.8 0.082 12.9 2.4 1.5 2 0 0 2 2 2 0 Stathmin family BAR_3 PF16746.5 ETO12863.1 - 0.0001 22.1 0.3 0.00015 21.6 0.3 1.2 1 0 0 1 1 1 1 BAR domain of APPL family THOC7 PF05615.13 ETO12863.1 - 0.12 12.7 0.5 0.24 11.7 0.5 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 UxuA PF03786.13 ETO12864.1 - 2.3e-113 378.6 0.3 2.6e-113 378.4 0.3 1.0 1 0 0 1 1 1 1 D-mannonate dehydratase (UxuA) AP_endonuc_2 PF01261.24 ETO12864.1 - 0.00012 21.6 0.0 0.00045 19.7 0.0 2.0 1 1 0 1 1 1 1 Xylose isomerase-like TIM barrel RTP PF02334.16 ETO12864.1 - 0.068 13.8 0.6 0.2 12.3 0.1 2.0 2 0 0 2 2 2 0 Replication terminator protein DNA_ligase_A_N PF04675.14 ETO12865.1 - 0.029 14.7 0.0 0.067 13.5 0.0 1.8 1 1 0 1 1 1 0 DNA ligase N terminus Requiem_N PF14051.6 ETO12865.1 - 0.033 14.4 0.2 0.14 12.4 0.2 2.1 1 0 0 1 1 1 0 N-terminal domain of DPF2/REQ. Pkinase PF00069.25 ETO12866.1 - 5.2e-34 117.8 0.9 6.8e-34 117.4 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12866.1 - 2.4e-13 50.0 0.1 2.4e-13 50.0 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Pox_Ag35 PF03286.14 ETO12866.1 - 0.14 11.9 7.3 0.24 11.2 7.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Metallophos PF00149.28 ETO12867.1 - 3e-18 67.1 0.0 4.8e-18 66.4 0.0 1.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_4 PF13418.6 ETO12870.1 - 6.3e-32 109.3 0.2 9.7e-12 44.7 0.0 4.2 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO12870.1 - 3.2e-24 84.7 0.1 4.2e-09 36.5 0.0 4.9 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO12870.1 - 3.3e-23 81.2 0.1 2.7e-05 24.0 0.0 4.3 4 0 0 4 4 4 4 Kelch motif Kelch_1 PF01344.25 ETO12870.1 - 1.1e-21 76.2 0.2 6.7e-06 25.6 0.0 4.2 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 ETO12870.1 - 4.4e-20 71.2 2.8 8.9e-08 32.2 0.0 4.2 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO12870.1 - 6.1e-13 48.2 1.7 3.7e-06 26.7 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Shisa PF13908.6 ETO12871.1 - 0.00016 22.0 0.5 0.00021 21.6 0.5 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator Phage_holin_6_1 PF09682.10 ETO12871.1 - 0.00068 20.0 0.1 0.001 19.5 0.1 1.2 1 0 0 1 1 1 1 Bacteriophage holin of superfamily 6 (Holin_LLH) DAG1 PF05454.11 ETO12871.1 - 0.00083 18.8 0.1 0.00099 18.6 0.1 1.1 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) TMEM52 PF14979.6 ETO12871.1 - 0.016 15.1 0.5 0.032 14.1 0.3 1.6 1 1 1 2 2 2 0 Transmembrane 52 Vpu PF00558.19 ETO12871.1 - 0.024 14.4 0.7 0.036 13.8 0.3 1.6 1 1 1 2 2 2 0 Vpu protein Mem_trans PF03547.18 ETO12871.1 - 0.025 13.0 0.5 0.03 12.7 0.5 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF1634 PF07843.11 ETO12871.1 - 0.056 13.5 0.0 0.083 13.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) LRRC37AB_C PF14914.6 ETO12871.1 - 0.058 13.3 4.6 1.8 8.5 0.1 2.1 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Flu_M2 PF00599.17 ETO12871.1 - 0.071 13.2 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Influenza Matrix protein (M2) Orthoreo_P10 PF07204.11 ETO12871.1 - 0.073 13.0 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Adeno_E3_CR2 PF02439.15 ETO12871.1 - 0.1 12.4 3.2 0.18 11.6 3.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Comm PF15957.5 ETO12871.1 - 0.11 12.8 0.2 0.16 12.3 0.2 1.4 1 1 0 1 1 1 0 Commissureless SID-1_RNA_chan PF13965.6 ETO12871.1 - 0.11 10.8 0.8 0.13 10.6 0.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Phage_holin_3_6 PF07332.11 ETO12871.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III EphA2_TM PF14575.6 ETO12871.1 - 0.14 13.1 1.1 0.36 11.7 1.1 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Chordopox_A13L PF05961.11 ETO12871.1 - 0.15 12.3 0.1 0.39 11.0 0.1 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein Zip PF02535.22 ETO12871.1 - 0.43 9.8 1.2 0.53 9.4 1.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Thiolase_N PF00108.23 ETO12872.1 - 3.4e-60 203.6 0.0 4.5e-60 203.2 0.0 1.2 1 0 0 1 1 1 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETO12872.1 - 3.1e-38 130.2 0.0 7.2e-38 129.0 0.0 1.7 1 0 0 1 1 1 1 Thiolase, C-terminal domain ACP_syn_III_C PF08541.10 ETO12872.1 - 0.0063 16.7 0.0 0.017 15.3 0.0 1.7 1 0 0 1 1 1 1 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal ketoacyl-synt PF00109.26 ETO12872.1 - 0.022 14.4 0.2 0.053 13.1 0.2 1.6 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain DUF2256 PF10013.9 ETO12872.1 - 0.19 11.9 0.0 0.36 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-H2C2_2 PF13465.6 ETO12873.1 - 9.4e-06 25.8 1.1 9.4e-06 25.8 1.1 3.0 2 1 0 2 2 2 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO12873.1 - 9.8e-05 22.9 5.9 0.083 13.8 0.1 3.2 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ETO12873.1 - 0.00015 21.4 2.9 0.00016 21.3 0.1 2.4 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2 PF00096.26 ETO12873.1 - 0.0002 21.6 14.5 0.0025 18.2 0.1 3.4 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 ETO12873.1 - 0.018 15.3 2.7 0.061 13.6 2.7 1.9 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding Zn-ribbon_8 PF09723.10 ETO12873.1 - 0.099 12.8 0.9 0.21 11.7 0.9 1.5 1 0 0 1 1 1 0 Zinc ribbon domain zf-met PF12874.7 ETO12873.1 - 0.15 12.5 4.3 3.4 8.2 0.1 2.9 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ETO12873.1 - 0.39 11.1 4.3 13 6.2 0.1 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 ETO12873.1 - 0.93 9.6 7.7 5.3 7.1 3.1 3.0 1 1 1 2 2 2 0 BED zinc finger Adaptin_binding PF10199.9 ETO12874.1 - 9.5 6.9 12.7 0.29 11.7 1.3 3.3 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 DNA_pol_B_exo1 PF03104.19 ETO12875.1 - 4.6e-08 32.6 2.0 3.1e-07 29.9 2.0 2.0 1 1 0 1 1 1 1 DNA polymerase family B, exonuclease domain DUF1156 PF06634.12 ETO12875.1 - 0.13 12.4 0.0 0.33 11.1 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) ALMT PF11744.8 ETO12876.1 - 1.9 7.2 9.2 1.9 7.2 9.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Mito_fiss_reg PF05308.11 ETO12879.1 - 0.72 9.9 20.4 0.056 13.5 13.5 2.3 2 0 0 2 2 2 0 Mitochondrial fission regulator FERM_M PF00373.18 ETO12879.1 - 4.2 7.8 5.8 10 6.5 0.1 3.6 4 1 0 4 4 4 0 FERM central domain FdhE PF04216.12 ETO12879.1 - 8 6.2 8.2 19 5.0 0.6 2.4 2 0 0 2 2 2 0 Protein involved in formate dehydrogenase formation Gram_pos_anchor PF00746.21 ETO12880.1 - 0.77 9.8 3.5 38 4.3 0.0 3.3 3 0 0 3 3 3 0 LPXTG cell wall anchor motif zf-C4H2 PF10146.9 ETO12882.1 - 0.017 15.4 1.5 0.018 15.3 1.5 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein RPA_C PF08784.11 ETO12883.1 - 0.0031 18.1 0.1 0.0055 17.4 0.1 1.4 1 0 0 1 1 1 1 Replication protein A C terminal YusW PF14039.6 ETO12883.1 - 0.011 16.2 5.0 0.064 13.8 2.1 2.1 2 0 0 2 2 2 0 YusW-like protein F-protein PF00469.20 ETO12883.1 - 0.32 10.6 3.7 0.36 10.4 3.6 1.2 1 1 0 1 1 1 0 Negative factor, (F-Protein) or Nef TMEM237 PF15383.6 ETO12884.1 - 0.00065 18.9 0.2 0.00083 18.5 0.2 1.1 1 0 0 1 1 1 1 Transmembrane protein 237 DUF853 PF05872.12 ETO12884.1 - 0.044 12.4 0.2 0.052 12.1 0.2 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CactinC_cactus PF09732.9 ETO12885.1 - 1.2e-54 183.6 9.9 3.4e-54 182.1 9.9 1.8 1 0 0 1 1 1 1 Cactus-binding C-terminus of cactin protein Cactin_mid PF10312.9 ETO12885.1 - 6e-40 137.1 10.4 6e-40 137.1 10.4 3.1 3 0 0 3 3 3 1 Conserved mid region of cactin ATP-grasp_6 PF18419.1 ETO12886.1 - 0.39 10.4 3.8 2.2 8.0 0.4 2.4 2 1 0 2 2 2 0 ATP-grasp-like domain TPR_12 PF13424.6 ETO12887.1 - 4.5e-84 276.8 18.2 7.7e-18 64.6 2.0 6.8 2 2 6 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO12887.1 - 2.6e-53 176.5 0.4 2.2e-06 27.3 0.1 10.2 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO12887.1 - 3.5e-43 142.5 12.5 3.7e-06 26.6 0.0 10.6 11 0 0 11 11 11 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO12887.1 - 3.7e-43 143.6 43.8 6.5e-08 32.1 0.1 10.5 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO12887.1 - 1.8e-40 133.8 49.3 1.7e-06 27.8 0.2 10.6 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO12887.1 - 8.9e-38 125.4 38.1 1e-06 28.4 0.2 10.5 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO12887.1 - 1.5e-20 73.9 0.0 4.7e-09 36.1 0.0 3.2 1 1 2 3 3 3 3 MalT-like TPR region TPR_14 PF13428.6 ETO12887.1 - 7e-16 57.6 0.0 0.16 12.9 0.0 8.8 8 2 1 9 9 8 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO12887.1 - 1.1e-11 44.5 15.2 0.0067 17.0 0.2 8.2 9 0 0 9 9 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO12887.1 - 2.6e-09 37.6 3.7 0.13 13.0 0.1 6.4 5 2 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO12887.1 - 4.5e-09 36.1 9.9 7.8 7.1 0.1 9.7 10 0 0 10 10 9 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO12887.1 - 1.3e-08 34.8 24.1 0.67 9.7 0.0 8.2 5 2 3 8 8 8 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO12887.1 - 2.4e-05 23.9 39.4 0.28 10.9 0.5 9.3 8 1 1 9 9 9 3 TPR repeat TPR_19 PF14559.6 ETO12887.1 - 3.2e-05 24.3 2.6 0.85 10.2 0.1 5.5 5 2 1 6 6 6 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO12887.1 - 3.8e-05 23.5 20.0 0.004 16.9 7.3 4.4 3 2 0 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) DUF3856 PF12968.7 ETO12887.1 - 0.00013 22.1 7.4 0.0026 17.8 1.1 3.9 3 1 1 4 4 3 1 Domain of Unknown Function (DUF3856) TPR_21 PF09976.9 ETO12887.1 - 0.00041 20.1 3.3 0.32 10.7 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat-like domain ANAPC3 PF12895.7 ETO12887.1 - 0.00052 20.2 20.3 0.47 10.7 0.1 6.3 4 1 2 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETO12887.1 - 0.0021 18.2 0.0 0.35 11.0 0.0 3.3 2 1 1 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO12887.1 - 0.026 14.6 38.8 0.16 12.1 0.1 8.1 7 2 2 9 9 8 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO12887.1 - 0.032 13.9 19.1 0.14 11.8 3.0 5.7 2 2 4 6 6 6 0 26S proteasome subunit RPN7 Prefoldin PF02996.17 ETO12887.1 - 0.055 13.4 0.0 0.055 13.4 0.0 4.3 5 0 0 5 5 5 0 Prefoldin subunit TPR_3 PF07720.12 ETO12887.1 - 0.061 13.3 26.1 0.086 12.9 0.3 7.3 7 0 0 7 7 7 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO12887.1 - 0.17 12.6 24.0 3.9 8.3 0.2 8.1 10 0 0 10 10 8 0 Sel1 repeat Med2 PF11214.8 ETO12887.1 - 0.29 11.3 6.1 0.25 11.5 3.3 2.4 2 0 0 2 2 1 0 Mediator complex subunit 2 DUF627 PF04781.12 ETO12887.1 - 0.4 10.7 11.6 2.2 8.3 0.0 4.9 4 2 1 5 5 4 0 Protein of unknown function (DUF627) Mob_Pre PF01076.19 ETO12887.1 - 8.2 6.2 27.9 2.9 7.7 0.1 5.8 5 2 1 6 6 6 0 Plasmid recombination enzyme MIEAP PF16026.5 ETO12890.1 - 5.5e-07 30.0 0.3 6.9e-07 29.7 0.3 1.2 1 0 0 1 1 1 1 Mitochondria-eating protein DUF2624 PF11116.8 ETO12890.1 - 0.16 12.9 1.7 4.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2624) Macoilin PF09726.9 ETO12891.1 - 8.9 4.7 19.7 17 3.8 19.7 1.5 1 0 0 1 1 1 0 Macoilin family Mem_trans PF03547.18 ETO12892.1 - 9.5 4.5 9.0 1.1e+02 0.9 9.0 2.1 1 1 0 1 1 1 0 Membrane transport protein PRY PF13765.6 ETO12893.1 - 0.075 12.7 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 SPRY-associated domain DUF4518 PF15008.6 ETO12895.1 - 0.0017 17.6 7.1 0.0022 17.2 5.8 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4518) Androgen_recep PF02166.16 ETO12895.1 - 0.15 10.9 8.6 0.18 10.7 8.6 1.2 1 0 0 1 1 1 0 Androgen receptor Spt20 PF12090.8 ETO12895.1 - 0.19 11.3 18.7 0.29 10.7 18.7 1.3 1 0 0 1 1 1 0 Spt20 family Suf PF05843.14 ETO12895.1 - 0.57 10.1 12.4 0.67 9.9 12.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Hydin_ADK PF17213.3 ETO12895.1 - 0.68 10.2 7.7 0.89 9.8 7.7 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 ETO12895.1 - 1.2 7.8 9.4 1.3 7.7 9.4 1.1 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 ETO12895.1 - 2.8 7.0 7.8 3.4 6.7 7.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein Sec62 PF03839.16 ETO12895.1 - 3.3 7.2 10.1 4.3 6.8 10.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Neur_chan_memb PF02932.16 ETO12895.1 - 6.5 6.7 8.1 7.8 6.5 8.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DENN PF02141.21 ETO12897.1 - 5.6e-32 111.2 2.5 1.8e-25 90.0 0.7 2.5 2 0 0 2 2 2 2 DENN (AEX-3) domain uDENN PF03456.18 ETO12897.1 - 1.2e-14 54.8 0.8 3.8e-08 34.0 0.2 3.0 3 0 0 3 3 3 2 uDENN domain Tubulin PF00091.25 ETO12898.1 - 1.3e-32 113.6 0.8 9.5e-32 110.8 0.8 2.3 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO12898.1 - 4e-14 52.9 0.0 6.5e-14 52.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain DcpS_C PF11969.8 ETO12899.1 - 5.2e-12 46.2 2.7 2e-11 44.4 2.7 2.0 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding ZnuA PF01297.17 ETO12899.1 - 0.021 14.2 0.1 0.031 13.7 0.1 1.3 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Pox_polyA_pol_N PF12630.7 ETO12899.1 - 0.16 12.4 2.3 1.4 9.4 0.1 3.0 3 0 0 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain XRN_M PF17846.1 ETO12900.1 - 0.00085 18.4 1.2 0.0012 17.9 1.2 1.2 1 0 0 1 1 1 1 Xrn1 helical domain Sporozoite_P67 PF05642.11 ETO12902.1 - 3.9 5.5 28.4 0.03 12.4 19.6 1.8 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Daxx PF03344.15 ETO12903.1 - 0.02 14.9 0.0 0.037 14.1 0.0 1.6 1 0 0 1 1 1 0 Daxx N-terminal Rassf1C-interacting domain WD40 PF00400.32 ETO12904.1 - 1.8e-51 171.0 9.7 1.3e-09 38.5 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12904.1 - 6.3e-25 87.3 0.2 2e-05 24.8 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12904.1 - 7e-22 77.8 0.1 0.00043 19.3 0.0 6.1 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12904.1 - 3.6e-10 39.7 0.8 0.0062 15.9 0.0 3.6 1 1 4 5 5 5 5 WD40-like domain eIF2A PF08662.11 ETO12904.1 - 1.3e-08 35.0 0.0 0.059 13.3 0.0 3.8 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO12904.1 - 1.7e-08 33.6 0.9 3.9 6.0 0.0 5.0 3 1 2 5 5 5 5 Nucleoporin Nup120/160 PD40 PF07676.12 ETO12904.1 - 2.5e-07 30.5 5.8 1.3 9.1 0.0 5.7 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO12904.1 - 4.2e-07 29.6 0.9 0.9 8.8 0.0 5.0 1 1 5 6 6 6 2 Neuroblastoma-amplified sequence, N terminal Utp8 PF10395.9 ETO12904.1 - 5.8e-06 25.1 0.1 0.093 11.2 0.0 3.1 2 1 1 3 3 3 2 Utp8 family DUF5570 PF17731.1 ETO12904.1 - 8.9e-06 25.8 0.1 5.2 7.2 0.0 4.4 1 1 4 5 5 5 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO12904.1 - 0.0001 21.0 0.2 0.16 10.5 0.0 3.0 2 1 0 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO12904.1 - 0.00031 19.6 5.4 0.38 9.4 0.0 3.4 1 1 2 4 4 4 2 Nup133 N terminal like Ubiquitin_3 PF14836.6 ETO12904.1 - 0.0014 18.6 0.9 14 5.7 0.0 4.0 2 1 3 5 5 4 0 Ubiquitin-like domain DPPIV_N PF00930.21 ETO12904.1 - 0.0019 17.0 0.0 1.1 8.0 0.0 3.7 2 2 2 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Frtz PF11768.8 ETO12904.1 - 0.006 15.0 0.1 1.2 7.4 0.0 2.7 1 1 1 3 3 3 1 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 ETO12904.1 - 0.0092 14.9 0.8 12 4.7 0.0 3.9 2 2 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain HPS6 PF15702.5 ETO12904.1 - 0.061 11.3 0.0 48 1.7 0.0 3.8 1 1 3 5 5 5 0 Hermansky-Pudlak syndrome 6 protein HARP PF07443.13 ETO12904.1 - 0.079 12.6 0.0 7.2 6.3 0.0 3.3 3 0 0 3 3 3 0 HepA-related protein (HARP) TFIIIC_delta PF12657.7 ETO12904.1 - 0.088 12.7 0.1 2.3 8.1 0.1 2.8 1 1 1 2 2 2 0 Transcription factor IIIC subunit delta N-term PQQ PF01011.21 ETO12904.1 - 0.16 12.0 0.0 47 4.1 0.0 4.2 5 1 0 5 5 4 0 PQQ enzyme repeat ArlS_N PF18719.1 ETO12904.1 - 0.19 11.9 0.4 8.6 6.6 0.0 3.1 3 1 0 3 3 3 0 ArlS sensor domain CHAT PF12770.7 ETO12905.1 - 4e-12 46.1 0.1 5.5e-12 45.7 0.1 1.3 1 0 0 1 1 1 1 CHAT domain Peptidase_C25 PF01364.18 ETO12905.1 - 0.001 18.4 0.0 0.0015 17.8 0.0 1.4 1 0 0 1 1 1 1 Peptidase family C25 Peptidase_C14 PF00656.22 ETO12905.1 - 0.0024 17.9 0.0 0.0026 17.8 0.0 1.2 1 0 0 1 1 1 1 Caspase domain Raptor_N PF14538.6 ETO12905.1 - 0.061 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Raptor N-terminal CASPase like domain Secretin_N_2 PF07655.13 ETO12905.1 - 0.17 12.5 9.9 0.29 11.7 9.9 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Secretin_N_2 PF07655.13 ETO12906.1 - 0.21 12.1 11.1 0.53 10.9 11.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Thiolase_N PF00108.23 ETO12907.1 - 4.8e-58 196.6 1.0 5.7e-35 120.9 0.1 3.5 3 1 0 3 3 3 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETO12907.1 - 1.8e-42 143.8 0.4 3.9e-42 142.8 0.4 1.6 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ETO12907.1 - 0.096 12.3 0.7 0.2 11.2 0.1 1.8 2 0 0 2 2 2 0 Beta-ketoacyl synthase, N-terminal domain B56 PF01603.20 ETO12908.1 - 0.0083 15.1 0.1 0.0083 15.1 0.1 1.6 2 0 0 2 2 2 1 Protein phosphatase 2A regulatory B subunit (B56 family) Senescence PF06911.12 ETO12909.1 - 3.6e-11 43.7 16.9 6.8e-08 33.0 3.7 2.7 2 1 1 3 3 3 2 Senescence-associated protein Zip PF02535.22 ETO12909.1 - 0.21 10.8 4.5 0.15 11.3 1.2 2.0 1 1 1 2 2 2 0 ZIP Zinc transporter E7 PF00527.18 ETO12909.1 - 6.3 7.1 5.4 2.3 8.5 0.0 2.9 4 1 0 4 4 4 0 E7 protein, Early protein T3SchapCesA PF11439.8 ETO12910.1 - 0.23 11.6 2.2 0.3 11.3 0.6 2.0 1 1 1 2 2 2 0 Type III secretion system filament chaperone CesA Beta-lactamase PF00144.24 ETO12912.1 - 1.6e-23 83.5 0.0 1.3e-19 70.6 0.0 2.1 2 0 0 2 2 2 2 Beta-lactamase BUD22 PF09073.10 ETO12912.1 - 0.00069 19.1 25.6 0.00095 18.6 25.6 1.1 1 0 0 1 1 1 1 BUD22 AvrLm4-7 PF18661.1 ETO12912.1 - 0.033 15.2 1.1 0.063 14.3 0.3 1.9 2 0 0 2 2 2 0 Avirulence Effector AvrLm4-7 Macoilin PF09726.9 ETO12912.1 - 0.052 12.1 25.8 0.064 11.8 25.8 1.1 1 0 0 1 1 1 0 Macoilin family PAP1 PF08601.10 ETO12912.1 - 0.079 12.7 26.8 0.12 12.0 26.8 1.3 1 0 0 1 1 1 0 Transcription factor PAP1 Herpes_capsid PF06112.11 ETO12912.1 - 0.16 12.0 22.7 0.28 11.2 22.7 1.4 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein SWIRM-assoc_2 PF16496.5 ETO12912.1 - 1.2 8.0 19.1 1.6 7.5 19.1 1.1 1 0 0 1 1 1 0 SWIRM-associated domain at the N-terminal PI3K_1B_p101 PF10486.9 ETO12912.1 - 1.5 6.5 17.5 2.4 5.8 17.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1387 PF07139.11 ETO12912.1 - 1.5 8.4 24.7 2.5 7.8 24.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Hamartin PF04388.12 ETO12912.1 - 3.4 6.2 15.4 4.3 5.9 15.4 1.1 1 0 0 1 1 1 0 Hamartin protein CDC27 PF09507.10 ETO12913.1 - 0.018 14.4 22.0 0.018 14.5 22.0 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 PPP4R2 PF09184.11 ETO12913.1 - 0.12 12.0 26.9 0.13 11.8 26.9 1.1 1 0 0 1 1 1 0 PPP4R2 Nucleo_P87 PF07267.11 ETO12913.1 - 0.15 10.9 14.2 0.17 10.7 14.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.12 ETO12913.1 - 3.2 5.8 26.4 3.5 5.7 26.4 1.0 1 0 0 1 1 1 0 Nop14-like family FAM60A PF15396.6 ETO12913.1 - 3.4 7.6 16.2 3.6 7.5 16.2 1.1 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 ETO12913.1 - 3.5 7.4 20.4 5 6.9 20.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NOA36 PF06524.12 ETO12913.1 - 4.7 6.4 25.5 5.7 6.2 25.5 1.1 1 0 0 1 1 1 0 NOA36 protein LtrA PF06772.11 ETO12914.1 - 6.2e-12 45.4 20.9 6.2e-12 45.4 20.9 2.7 2 1 0 2 2 2 1 Bacterial low temperature requirement A protein (LtrA) DUF3290 PF11694.8 ETO12914.1 - 0.53 10.2 6.7 2.7 7.9 0.0 3.7 2 1 0 3 3 3 0 Protein of unknown function (DUF3290) UPF0542 PF15086.6 ETO12914.1 - 3 7.8 7.5 4.6 7.2 0.1 3.6 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 BBP2_2 PF10082.9 ETO12915.1 - 0.013 14.4 2.3 0.017 14.0 2.3 1.3 1 0 0 1 1 1 0 Putative beta-barrel porin 2 ERGIC_N PF13850.6 ETO12915.1 - 1.3 9.4 4.5 8.4 6.8 1.1 2.3 1 1 1 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Filament PF00038.21 ETO12916.1 - 0.00094 18.9 15.9 0.00094 18.9 15.9 3.9 3 1 1 4 4 4 2 Intermediate filament protein LMBR1 PF04791.16 ETO12916.1 - 0.0015 17.5 34.1 0.0081 15.1 16.2 3.3 1 1 1 2 2 2 1 LMBR1-like membrane protein CEP63 PF17045.5 ETO12916.1 - 0.0044 17.0 16.9 0.0044 17.0 16.9 4.2 4 1 0 4 4 4 2 Centrosomal protein of 63 kDa MbeD_MobD PF04899.12 ETO12916.1 - 0.01 15.9 0.1 0.01 15.9 0.1 5.3 4 3 0 4 4 3 0 MbeD/MobD like TPR_MLP1_2 PF07926.12 ETO12916.1 - 0.033 14.3 58.1 0.12 12.4 9.4 5.1 4 1 1 5 5 5 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 ETO12916.1 - 0.055 12.6 41.7 0.047 12.8 13.2 3.2 3 0 0 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Ycf70 PF17382.2 ETO12916.1 - 0.06 13.8 0.4 0.06 13.8 0.4 3.5 4 0 0 4 4 4 0 Uncharacterized Ycf70-like ETRAMP PF09716.10 ETO12916.1 - 0.068 13.2 0.5 0.068 13.2 0.5 3.1 3 1 0 3 3 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF4407 PF14362.6 ETO12916.1 - 0.14 11.5 31.6 0.02 14.2 6.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) Baculo_PEP_C PF04513.12 ETO12916.1 - 0.27 11.3 20.6 7.3 6.6 0.0 4.4 4 1 0 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1378 PF07125.11 ETO12916.1 - 0.38 11.0 8.0 7 6.9 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1378) IFT20 PF14931.6 ETO12916.1 - 0.42 10.8 41.3 0.074 13.2 14.4 5.1 5 0 0 5 5 5 0 Intraflagellar transport complex B, subunit 20 DUF3450 PF11932.8 ETO12916.1 - 0.5 9.6 46.2 0.96 8.7 13.9 4.8 4 1 1 5 5 5 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 ETO12916.1 - 0.82 9.7 64.2 0.69 10.0 23.1 3.8 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus CCDC144C PF14915.6 ETO12916.1 - 2.6 7.1 56.8 0.055 12.6 22.2 4.2 4 1 0 4 4 4 0 CCDC144C protein coiled-coil region APG6_N PF17675.1 ETO12916.1 - 4.4 7.8 58.2 0.1 13.1 19.3 4.4 3 1 1 4 4 4 0 Apg6 coiled-coil region FPP PF05911.11 ETO12916.1 - 7.2 4.7 47.3 0.17 10.0 12.2 3.1 2 1 0 3 3 3 0 Filament-like plant protein, long coiled-coil ATP-cone PF03477.16 ETO12917.1 - 1.3 9.6 4.9 1.5 9.4 2.4 2.2 2 0 0 2 2 2 0 ATP cone domain DUF445 PF04286.12 ETO12918.1 - 0.77 9.5 5.3 2 8.1 5.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF445) PrkA PF06798.12 ETO12918.1 - 2.9 7.4 5.7 1.4 8.5 0.6 2.6 2 2 1 4 4 4 0 PrkA serine protein kinase C-terminal domain B56 PF01603.20 ETO12920.1 - 4.3e-144 480.5 7.5 4.8e-144 480.4 7.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) PI3_PI4_kinase PF00454.27 ETO12921.1 - 2.6e-31 109.3 1.4 2e-24 86.8 0.0 3.2 3 1 1 4 4 4 2 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETO12921.1 - 1.7e-11 43.9 0.1 4.1e-11 42.6 0.1 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF4135 PF13575.6 ETO12921.1 - 0.0096 15.3 0.0 0.021 14.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) MAGUK_N_PEST PF10608.9 ETO12922.1 - 2.4 8.6 11.1 0.45 11.0 5.6 2.0 2 0 0 2 2 2 0 Polyubiquitination (PEST) N-terminal domain of MAGUK TP53IP5 PF15331.6 ETO12924.1 - 3.5 7.7 12.9 5.2 7.1 12.9 1.3 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Rgp1 PF08737.10 ETO12927.1 - 3.4e-12 46.3 0.7 3.4e-12 46.3 0.7 2.1 2 1 0 2 2 2 1 Rgp1 FAM176 PF14851.6 ETO12928.1 - 0.18 11.4 5.8 0.66 9.6 5.8 2.0 1 0 0 1 1 1 0 FAM176 family DUF5568 PF17724.1 ETO12928.1 - 0.26 11.1 1.1 21 4.9 0.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5568) Neur_chan_memb PF02932.16 ETO12928.1 - 0.26 11.3 1.5 0.59 10.2 1.5 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ferlin_C PF16165.5 ETO12928.1 - 1 9.3 8.2 1.6 8.7 6.4 2.2 2 0 0 2 2 2 0 Ferlin C-terminus G-alpha PF00503.20 ETO12929.1 - 4.4e-23 82.0 4.5 7.2e-23 81.3 4.5 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 ETO12929.1 - 0.0015 18.8 3.5 0.012 15.8 0.4 2.7 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO12929.1 - 0.0024 17.3 1.7 0.034 13.6 0.1 2.9 2 1 1 3 3 3 1 ADP-ribosylation factor family AAA_16 PF13191.6 ETO12929.1 - 0.016 15.6 0.0 0.028 14.8 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 ETO12929.1 - 0.026 14.3 0.4 0.11 12.3 0.2 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 ETO12929.1 - 0.037 14.0 0.3 0.12 12.5 0.3 1.9 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO12929.1 - 0.11 12.4 3.7 0.28 11.1 0.1 2.6 3 0 0 3 3 3 0 NACHT domain TniB PF05621.11 ETO12929.1 - 0.11 11.9 0.2 0.11 11.9 0.2 1.7 2 0 0 2 2 2 0 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 ETO12929.1 - 0.15 11.3 0.1 0.36 10.1 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_22 PF13401.6 ETO12929.1 - 0.26 11.6 1.3 0.93 9.8 0.6 2.3 1 1 1 2 2 2 0 AAA domain DUF4407 PF14362.6 ETO12929.1 - 1.3 8.3 5.5 1.8 7.9 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ribosomal_L24e PF01246.20 ETO12930.1 - 1.9e-23 82.4 1.5 1.9e-23 82.4 1.5 2.3 3 0 0 3 3 3 1 Ribosomal protein L24e DUF726 PF05277.12 ETO12933.1 - 0.11 11.5 3.7 0.22 10.4 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF726) DUF2407_C PF13373.6 ETO12933.1 - 1.1 9.5 3.8 8.9 6.5 0.0 3.0 3 0 0 3 3 3 0 DUF2407 C-terminal domain CRAL_TRIO_2 PF13716.6 ETO12933.1 - 1.7 8.8 7.5 2.6 8.2 0.3 2.5 1 1 1 2 2 2 0 Divergent CRAL/TRIO domain Gly-zipper_YMGG PF13441.6 ETO12933.1 - 3.5 7.5 45.7 0.59 9.9 15.9 2.2 1 1 1 2 2 2 0 YMGG-like Gly-zipper Keratin_2_head PF16208.5 ETO12933.1 - 4.2 7.5 16.0 6.5 6.9 16.0 1.2 1 0 0 1 1 1 0 Keratin type II head MCM_lid PF17855.1 ETO12934.1 - 0.00084 19.7 0.5 0.0034 17.8 0.5 2.1 1 1 0 1 1 1 1 MCM AAA-lid domain DUF2207 PF09972.9 ETO12934.1 - 0.0063 15.3 0.1 0.0063 15.3 0.1 2.1 2 1 1 3 3 3 1 Predicted membrane protein (DUF2207) DASH_Ask1 PF08655.10 ETO12934.1 - 0.18 11.7 4.4 0.35 10.8 1.0 2.9 2 0 0 2 2 2 0 DASH complex subunit Ask1 ETRAMP PF09716.10 ETO12935.1 - 3e-05 24.0 1.0 7.6e-05 22.7 1.0 1.7 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) Nucleoside_tran PF01733.18 ETO12935.1 - 0.012 15.0 0.1 0.02 14.3 0.1 1.3 1 0 0 1 1 1 0 Nucleoside transporter FAM176 PF14851.6 ETO12935.1 - 0.071 12.8 0.5 0.12 12.0 0.5 1.3 1 0 0 1 1 1 0 FAM176 family CRA PF06589.11 ETO12935.1 - 0.079 13.1 3.1 0.15 12.1 3.1 1.5 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Uds1 PF15456.6 ETO12935.1 - 1.5 9.0 7.9 3.5 7.8 4.9 2.3 2 0 0 2 2 2 0 Up-regulated During Septation DUF4446 PF14584.6 ETO12935.1 - 1.9 8.5 5.2 5.3 7.0 1.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) GyrB_insert PF18053.1 ETO12936.1 - 0.025 14.5 1.4 0.033 14.1 1.4 1.1 1 0 0 1 1 1 0 DNA gyrase B subunit insert domain RNA_polI_A14 PF08203.11 ETO12936.1 - 0.14 12.9 3.1 0.23 12.2 2.9 1.5 1 1 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 Presenilin PF01080.17 ETO12936.1 - 1 8.1 4.1 1.2 7.9 4.1 1.1 1 0 0 1 1 1 0 Presenilin DUF5601 PF18151.1 ETO12938.1 - 0.054 13.8 2.1 0.25 11.7 2.1 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5601) PSII_Pbs27 PF13326.6 ETO12938.1 - 0.43 10.9 8.1 0.12 12.6 3.3 2.0 1 1 1 2 2 2 0 Photosystem II Pbs27 Exonuc_VII_L PF02601.15 ETO12938.1 - 1.4 8.4 9.9 2.9 7.4 9.9 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit Allexi_40kDa PF05549.11 ETO12938.1 - 1.8 8.0 7.6 0.27 10.7 2.4 1.8 1 1 1 2 2 2 0 Allexivirus 40kDa protein Tho2 PF11262.8 ETO12938.1 - 3.7 6.7 15.2 0.18 11.0 5.3 2.1 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF726 PF05277.12 ETO12939.1 - 0.0035 16.3 0.3 0.0053 15.7 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF726) Occludin_ELL PF07303.13 ETO12939.1 - 9.1 7.1 10.3 7 7.4 6.9 2.3 2 1 0 2 2 2 0 Occludin homology domain SET PF00856.28 ETO12940.1 - 0.0062 16.9 0.2 0.0089 16.4 0.2 1.2 1 0 0 1 1 1 1 SET domain Toxin_35 PF10530.9 ETO12940.1 - 0.04 13.9 3.6 0.067 13.2 3.6 1.3 1 0 0 1 1 1 0 Toxin with inhibitor cystine knot ICK or Knottin scaffold ANAPC4_WD40 PF12894.7 ETO12942.1 - 8.4e-06 26.0 0.0 3.1e-05 24.2 0.0 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO12942.1 - 0.00012 22.8 0.0 0.00097 19.9 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Nbas_N PF15492.6 ETO12942.1 - 0.0096 15.3 0.1 0.021 14.1 0.0 1.6 2 0 0 2 2 2 1 Neuroblastoma-amplified sequence, N terminal WD40 PF00400.32 ETO12943.1 - 6.7e-33 112.2 21.4 2.9e-08 34.2 0.1 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12943.1 - 7.1e-11 42.3 4.7 0.0099 16.2 0.0 5.6 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO12943.1 - 7.9e-09 34.7 5.5 0.36 9.4 0.0 5.7 1 1 4 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO12943.1 - 0.014 14.2 5.7 0.082 11.6 0.8 3.0 1 1 0 2 2 2 0 Nup133 N terminal like BBS2_Mid PF14783.6 ETO12943.1 - 0.029 14.4 4.2 0.062 13.3 0.2 3.4 3 2 2 5 5 5 0 Ciliary BBSome complex subunit 2, middle region DUF1541 PF07563.11 ETO12943.1 - 0.13 12.2 0.6 62 3.6 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1541) Integrin_B_tail PF07965.12 ETO12943.1 - 0.17 12.4 3.8 2.1 8.9 0.9 2.6 2 0 0 2 2 2 0 Integrin beta tail domain DSL PF01414.19 ETO12943.1 - 0.19 12.0 5.0 1.1 9.6 1.5 2.7 2 0 0 2 2 2 0 Delta serrate ligand Kinesin PF00225.23 ETO12944.1 - 1.2e-46 159.2 1.9 1.9e-46 158.6 1.9 1.2 1 0 0 1 1 1 1 Kinesin motor domain bZIP_2 PF07716.15 ETO12944.1 - 0.034 14.2 5.6 0.11 12.6 5.6 1.9 1 1 0 1 1 1 0 Basic region leucine zipper Shugoshin_N PF07558.11 ETO12944.1 - 0.096 12.6 0.5 0.096 12.6 0.5 2.0 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Metallophos PF00149.28 ETO12945.1 - 7.3e-06 26.6 0.2 9e-06 26.3 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO12945.1 - 0.0015 18.7 0.0 0.0048 17.1 0.0 1.7 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain zf-RanBP PF00641.18 ETO12947.1 - 0.0023 17.2 1.9 0.004 16.4 1.9 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others NOA36 PF06524.12 ETO12947.1 - 0.011 15.1 6.7 0.016 14.6 6.7 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO12947.1 - 0.013 15.9 2.5 0.022 15.1 2.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cript PF10235.9 ETO12947.1 - 0.03 14.9 0.8 0.03 14.9 0.8 2.1 2 1 0 2 2 2 0 Microtubule-associated protein CRIPT Ferlin_C PF16165.5 ETO12947.1 - 0.039 13.9 3.0 0.063 13.2 3.0 1.4 1 0 0 1 1 1 0 Ferlin C-terminus Atrophin-1 PF03154.15 ETO12947.1 - 0.07 11.4 4.9 0.087 11.1 4.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF4820 PF16091.5 ETO12947.1 - 0.07 12.5 2.3 0.099 12.0 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) A2L_zn_ribbon PF08792.10 ETO12947.1 - 0.46 10.3 2.8 1.1 9.1 2.8 1.7 1 1 0 1 1 1 0 A2L zinc ribbon domain DUF3915 PF13054.6 ETO12947.1 - 8 6.5 8.3 13 5.8 8.1 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) fn3 PF00041.21 ETO12948.1 - 4.7e-09 36.5 0.5 1.6e-05 25.2 0.0 3.0 3 0 0 3 3 3 2 Fibronectin type III domain Cwf_Cwc_15 PF04889.12 ETO12948.1 - 0.0054 16.5 15.0 0.0066 16.2 15.0 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 ETO12948.1 - 0.041 12.1 12.2 0.043 12.1 12.2 1.0 1 0 0 1 1 1 0 Nop14-like family Pur_ac_phosph_N PF16656.5 ETO12948.1 - 0.05 14.2 5.8 0.09 13.4 5.6 1.6 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain PKD_3 PF16820.5 ETO12948.1 - 0.058 13.1 0.1 0.15 11.8 0.0 1.7 2 0 0 2 2 2 0 PKD-like domain Trypan_PARP PF05887.11 ETO12948.1 - 0.077 13.0 4.4 0.1 12.6 4.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DDHD PF02862.17 ETO12948.1 - 0.086 13.0 3.9 0.097 12.8 3.9 1.1 1 0 0 1 1 1 0 DDHD domain Vfa1 PF08432.10 ETO12948.1 - 0.091 13.1 15.0 0.14 12.5 15.0 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 ETO12948.1 - 0.14 12.1 13.7 0.2 11.6 13.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 ETO12948.1 - 0.15 11.7 8.1 0.2 11.3 8.1 1.3 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ETO12948.1 - 0.19 10.0 11.1 0.2 9.9 11.1 1.0 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ETO12948.1 - 0.35 9.2 5.9 0.44 8.9 5.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Serinc PF03348.15 ETO12948.1 - 0.36 9.7 2.7 0.42 9.5 2.7 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RPOL_N PF14700.6 ETO12948.1 - 0.46 9.8 10.2 0.55 9.6 9.8 1.3 1 1 0 1 1 1 0 DNA-directed RNA polymerase N-terminal Presenilin PF01080.17 ETO12948.1 - 0.47 9.2 6.1 0.51 9.0 6.1 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO12948.1 - 0.47 9.6 4.0 0.46 9.7 4.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4820 PF16091.5 ETO12948.1 - 0.57 9.5 8.1 0.92 8.8 8.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DNA_pol_phi PF04931.13 ETO12948.1 - 0.81 7.7 16.9 1 7.3 16.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF913 PF06025.12 ETO12948.1 - 0.85 8.5 8.4 0.98 8.3 8.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MCM_bind PF09739.9 ETO12948.1 - 0.98 7.8 9.5 1.1 7.6 9.5 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF4746 PF15928.5 ETO12948.1 - 1.7 8.0 9.6 2.1 7.7 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CobT PF06213.12 ETO12948.1 - 1.8 7.9 12.9 2.1 7.7 12.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2151 PF10221.9 ETO12948.1 - 1.9 7.0 10.3 2.4 6.7 10.3 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator NOA36 PF06524.12 ETO12948.1 - 2.8 7.2 15.3 4.9 6.4 15.3 1.4 1 0 0 1 1 1 0 NOA36 protein NPR3 PF03666.13 ETO12948.1 - 2.9 6.6 14.2 3.5 6.3 14.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF5082 PF16888.5 ETO12949.1 - 0.00087 19.6 5.9 0.0034 17.7 0.2 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5082) DivIC PF04977.15 ETO12949.1 - 0.015 15.0 0.5 0.015 15.0 0.5 2.1 3 0 0 3 3 3 0 Septum formation initiator CEP209_CC5 PF16574.5 ETO12949.1 - 0.086 13.0 0.2 0.086 13.0 0.2 2.1 2 1 0 2 2 2 0 Coiled-coil region of centrosome protein CE290 ZapB PF06005.12 ETO12949.1 - 0.65 10.5 6.9 0.23 12.0 0.6 2.5 2 0 0 2 2 2 0 Cell division protein ZapB MCM_OB PF17207.3 ETO12949.1 - 1.8 8.4 7.9 3.3 7.6 7.7 1.6 1 1 0 1 1 1 0 MCM OB domain Ribosomal_L19e PF01280.20 ETO12950.1 - 3.3e-32 111.5 13.1 3.3e-32 111.5 13.1 3.2 2 2 0 2 2 2 1 Ribosomal protein L19e DUF3552 PF12072.8 ETO12950.1 - 3.6 7.0 22.7 1.9 7.9 20.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) Spt20 PF12090.8 ETO12950.1 - 5.1 6.6 15.7 7.8 6.0 15.7 1.3 1 0 0 1 1 1 0 Spt20 family Hid1 PF12722.7 ETO12950.1 - 8.9 4.3 12.9 12 3.9 12.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF2167 PF09935.9 ETO12951.1 - 0.037 13.2 0.1 0.051 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) DUF2089 PF09862.9 ETO12951.1 - 0.061 13.4 0.3 0.098 12.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2089) Pan_kinase PF03309.14 ETO12952.1 - 0.1 12.4 0.2 3 7.6 0.0 2.8 2 0 0 2 2 2 0 Type III pantothenate kinase LSM PF01423.22 ETO12953.1 - 1.5e-21 75.9 0.0 1.8e-21 75.6 0.0 1.1 1 0 0 1 1 1 1 LSM domain MMS22L_C PF14911.6 ETO12953.1 - 0.02 14.0 0.0 0.023 13.8 0.0 1.0 1 0 0 1 1 1 0 S-phase genomic integrity recombination mediator, C-terminal SM-ATX PF14438.6 ETO12953.1 - 0.085 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain Ras PF00071.22 ETO12954.1 - 1.5e-48 164.5 1.6 4.8e-24 84.8 0.0 2.2 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO12954.1 - 2.8e-27 95.3 2.4 4.4e-25 88.2 0.2 3.0 2 2 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO12954.1 - 3.2e-10 39.7 0.9 3.5e-06 26.6 0.0 2.2 1 1 1 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO12954.1 - 0.00026 21.0 0.1 0.0007 19.7 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 ETO12954.1 - 0.00031 20.2 2.2 0.031 13.7 0.0 2.1 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETO12954.1 - 0.00058 19.8 0.0 0.04 13.8 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase TniB PF05621.11 ETO12954.1 - 0.0016 17.9 0.2 0.044 13.2 0.0 2.1 2 0 0 2 2 2 1 Bacterial TniB protein Gtr1_RagA PF04670.12 ETO12954.1 - 0.0026 17.2 0.2 0.0084 15.5 0.0 1.8 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region AAA_7 PF12775.7 ETO12954.1 - 0.014 15.0 0.0 0.025 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region ArfGap PF01412.18 ETO12955.1 - 2.8e-12 46.7 0.1 1.1e-11 44.8 0.1 2.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf PDZ_3 PF17815.1 ETO12956.1 - 6.1e-35 120.2 0.1 1.2e-34 119.3 0.1 1.4 1 0 0 1 1 1 1 PDZ domain RasGAP_C PF03836.15 ETO12957.1 - 2.8e-10 40.5 5.5 1.1e-09 38.6 5.5 1.8 1 1 0 1 1 1 1 RasGAP C-terminus Striatin PF08232.12 ETO12957.1 - 0.012 16.2 1.7 0.02 15.5 1.7 1.3 1 0 0 1 1 1 0 Striatin family DUF2408 PF10303.9 ETO12957.1 - 0.59 10.7 5.3 1.5 9.4 5.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) WD40 PF00400.32 ETO12958.1 - 3.6e-44 147.9 12.7 5.4e-09 36.5 0.0 6.5 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO12958.1 - 6.2e-18 64.9 0.8 0.0023 18.2 0.0 6.1 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO12958.1 - 1.8e-12 46.9 0.6 0.0081 15.2 0.0 5.0 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO12958.1 - 4.6e-07 29.5 3.3 0.0067 15.8 0.4 3.8 1 1 2 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO12958.1 - 1.1e-06 27.4 1.3 2.6e-05 22.9 0.2 2.6 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO12958.1 - 0.001 17.9 0.8 1.9 7.0 0.1 4.4 3 1 2 5 5 5 1 Nucleoporin Nup120/160 PD40 PF07676.12 ETO12958.1 - 0.002 18.0 2.0 8.4 6.5 0.0 4.6 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO12958.1 - 0.0067 15.5 0.4 0.22 10.5 0.0 3.0 2 1 2 4 4 4 1 VID27 C-terminal WD40-like domain Gmad1 PF10647.9 ETO12958.1 - 0.013 15.2 0.0 3.3 7.4 0.0 2.3 2 0 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain PALB2_WD40 PF16756.5 ETO12958.1 - 0.16 10.8 1.9 2.8 6.8 0.1 3.3 2 2 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain PARG_cat PF05028.14 ETO12959.1 - 1.4e-06 27.9 5.3 0.00031 20.2 0.4 2.1 1 1 1 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) LRR_adjacent PF08191.11 ETO12959.1 - 0.2 11.9 0.7 0.48 10.7 0.7 1.6 1 0 0 1 1 1 0 LRR adjacent AgrB PF04647.15 ETO12959.1 - 9.7 5.5 9.9 0.44 9.8 1.2 2.8 3 1 1 4 4 4 0 Accessory gene regulator B Ras PF00071.22 ETO12960.1 - 2.9e-05 23.7 0.2 0.025 14.2 0.1 2.5 2 0 0 2 2 2 2 Ras family PdxA PF04166.12 ETO12960.1 - 0.048 13.1 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal phosphate biosynthetic protein PdxA eIF-5a PF01287.20 ETO12960.1 - 0.7 10.0 3.7 0.79 9.9 0.0 2.7 3 0 0 3 3 3 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold PI31_Prot_N PF11566.8 ETO12961.1 - 6.7e-12 45.5 3.1 2.4e-07 30.7 0.0 2.5 2 1 0 2 2 2 2 PI31 proteasome regulator N-terminal CD99L2 PF12301.8 ETO12961.1 - 0.062 13.6 0.2 0.062 13.6 0.2 1.8 2 0 0 2 2 2 0 CD99 antigen like protein 2 HEAT PF02985.22 ETO12963.1 - 0.013 15.7 0.2 9 6.9 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat DUF4042 PF13251.6 ETO12963.1 - 0.024 14.4 0.5 12 5.6 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4042) Proteasom_PSMB PF10508.9 ETO12963.1 - 0.033 12.7 6.7 1.9 6.9 0.1 4.1 4 1 2 6 6 6 0 Proteasome non-ATPase 26S subunit PNPase PF03726.14 ETO12963.1 - 0.072 13.6 2.3 0.2 12.2 2.3 1.8 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Laminin_G_3 PF13385.6 ETO12966.1 - 7.8e-09 35.9 0.0 2.1e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Peptidase_S49_N PF08496.10 ETO12966.1 - 4.9 7.2 6.2 2 8.5 2.3 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal BUD22 PF09073.10 ETO12967.1 - 0.13 11.6 13.8 0.2 11.0 13.8 1.2 1 0 0 1 1 1 0 BUD22 Zip PF02535.22 ETO12967.1 - 0.17 11.1 0.4 0.2 10.8 0.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO12967.1 - 0.52 9.0 5.9 0.097 11.4 2.6 1.4 2 0 0 2 2 2 0 Presenilin Nop14 PF04147.12 ETO12967.1 - 9.7 4.3 13.9 14 3.8 13.9 1.1 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 ETO12967.1 - 9.9 4.6 10.6 13 4.2 10.6 1.1 1 0 0 1 1 1 0 Macoilin family Mannosyl_trans PF05007.13 ETO12968.1 - 2.9e-39 135.5 45.1 1.2e-38 133.5 45.1 2.0 1 1 0 1 1 1 1 Mannosyltransferase (PIG-M) FixH PF05751.11 ETO12968.1 - 0.49 10.4 1.9 2.4 8.1 0.1 2.6 2 0 0 2 2 2 0 FixH TFIIS_C PF01096.18 ETO12969.1 - 4.5e-12 45.6 2.3 4.5e-12 45.6 2.3 2.6 3 0 0 3 3 3 1 Transcription factor S-II (TFIIS) C1_1 PF00130.22 ETO12969.1 - 0.0026 17.6 3.0 0.0026 17.6 3.0 2.4 2 1 0 2 2 2 1 Phorbol esters/diacylglycerol binding domain (C1 domain) RNA_POL_M_15KD PF02150.16 ETO12969.1 - 0.0042 16.9 9.9 0.023 14.5 2.9 3.2 3 0 0 3 3 3 1 RNA polymerases M/15 Kd subunit zf-RING_7 PF02591.15 ETO12969.1 - 0.0096 16.1 0.8 0.68 10.2 0.1 2.9 3 0 0 3 3 2 1 C4-type zinc ribbon domain TF_Zn_Ribbon PF08271.12 ETO12969.1 - 0.021 14.3 1.8 0.61 9.7 0.9 2.6 2 0 0 2 2 2 0 TFIIB zinc-binding SpoIIIAH PF12685.7 ETO12969.1 - 0.11 12.3 7.3 0.14 12.0 7.3 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Gti1_Pac2 PF09729.9 ETO12969.1 - 0.11 12.5 9.2 0.16 12.0 9.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family YrbL-PhoP_reg PF10707.9 ETO12969.1 - 0.32 10.5 4.7 0.35 10.3 3.8 1.5 1 1 0 1 1 1 0 PhoP regulatory network protein YrbL DUF2072 PF09845.9 ETO12969.1 - 0.55 10.5 14.6 3.7 7.8 0.1 2.6 1 1 1 2 2 2 0 Zn-ribbon containing protein Paired_CXXCH_1 PF09699.10 ETO12969.1 - 0.69 9.7 10.0 0.58 9.9 0.2 3.6 3 0 0 3 3 3 0 Doubled CXXCH motif (Paired_CXXCH_1) UBA2_C PF16195.5 ETO12969.1 - 0.96 10.2 8.4 0.42 11.3 5.9 1.7 2 0 0 2 2 2 0 SUMO-activating enzyme subunit 2 C-terminus DZR PF12773.7 ETO12969.1 - 1 9.4 12.6 0.61 10.2 2.5 2.5 2 1 0 2 2 2 0 Double zinc ribbon Zn_Tnp_IS1595 PF12760.7 ETO12969.1 - 3.1 7.9 10.3 23 5.1 4.7 2.9 2 1 0 2 2 2 0 Transposase zinc-ribbon domain Auto_anti-p27 PF06677.12 ETO12969.1 - 3.1 8.0 11.8 0.3 11.3 2.1 2.8 2 1 0 2 2 2 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) Neur_chan_memb PF02932.16 ETO12969.1 - 6.2 6.8 7.9 8.4 6.4 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO12969.1 - 7.5 5.2 7.3 8.3 5.1 7.3 1.1 1 0 0 1 1 1 0 Presenilin Abhydrolase_2 PF02230.16 ETO12970.1 - 7.2e-36 124.0 0.0 9.6e-36 123.6 0.0 1.0 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase FSH1 PF03959.13 ETO12970.1 - 5.6e-07 29.4 0.0 2.4e-06 27.3 0.0 1.9 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Abhydrolase_3 PF07859.13 ETO12970.1 - 0.044 13.6 0.0 0.06 13.2 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold IP_trans PF02121.18 ETO12971.1 - 0.011 15.4 0.0 0.014 15.0 0.0 1.2 1 0 0 1 1 1 0 Phosphatidylinositol transfer protein DUF986 PF06173.12 ETO12971.1 - 0.081 13.0 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF986) DUF4405 PF14358.6 ETO12972.1 - 0.0037 17.8 1.0 0.029 14.9 0.1 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF4405) KCH PF16944.5 ETO12972.1 - 0.0057 16.5 3.8 0.0069 16.2 3.8 1.1 1 0 0 1 1 1 1 Fungal potassium channel Cytochrom_B561 PF03188.16 ETO12972.1 - 0.0084 16.3 9.9 0.09 12.9 0.6 2.3 1 1 1 2 2 2 2 Eukaryotic cytochrome b561 DUF202 PF02656.15 ETO12972.1 - 0.013 15.9 2.9 2.5 8.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF202) Tetraspanin PF00335.20 ETO12972.1 - 0.022 14.5 4.7 0.028 14.1 4.7 1.3 1 0 0 1 1 1 0 Tetraspanin family DUF973 PF06157.11 ETO12972.1 - 0.048 12.7 4.4 0.056 12.5 4.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF973) DHHC PF01529.20 ETO12972.1 - 0.056 13.6 5.7 4.2 7.5 2.9 2.3 1 1 1 2 2 2 0 DHHC palmitoyltransferase DUF373 PF04123.13 ETO12972.1 - 0.076 12.5 2.4 0.08 12.4 2.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF3021 PF11457.8 ETO12972.1 - 0.096 13.0 7.4 0.44 10.9 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) DUF4079 PF13301.6 ETO12972.1 - 0.12 12.5 0.5 0.19 11.9 0.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) DUF4282 PF14110.6 ETO12972.1 - 0.15 12.8 10.1 0.53 11.1 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4282) DUF3487 PF11990.8 ETO12972.1 - 0.23 11.4 1.0 0.83 9.5 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3487) Ni_hydr_CYTB PF01292.20 ETO12972.1 - 0.28 10.7 3.1 1.4 8.5 3.1 2.0 1 1 0 1 1 1 0 Prokaryotic cytochrome b561 Claudin_2 PF13903.6 ETO12972.1 - 0.42 10.3 13.0 0.056 13.2 2.5 2.2 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin tight junction DUF2207 PF09972.9 ETO12972.1 - 6 5.5 7.8 19 3.9 7.8 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) FAM117 PF15388.6 ETO12973.1 - 3.1 7.2 0.0 3.1 7.2 0.0 2.5 3 0 0 3 3 3 0 Protein Family FAM117 2OG-FeII_Oxy_4 PF13661.6 ETO12974.1 - 2.3e-14 53.8 0.0 4.1e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ETO12974.1 - 2.1e-10 41.4 0.0 3.9e-10 40.5 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Phlebovirus_NSM PF07246.11 ETO12974.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M PB1-F2 PF11986.8 ETO12974.1 - 0.029 14.6 0.7 0.052 13.8 0.7 1.4 1 0 0 1 1 1 0 Influenza A Proapoptotic protein SDA1 PF05285.12 ETO12976.1 - 0.0064 16.0 18.5 0.0074 15.8 18.5 1.0 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 ETO12976.1 - 0.16 10.3 9.7 0.16 10.2 9.7 1.0 1 0 0 1 1 1 0 CDC45-like protein MSP1a PF11670.8 ETO12976.1 - 0.18 11.0 0.1 0.22 10.8 0.1 1.1 1 0 0 1 1 1 0 Major surface protein 1a (MSP1a) Nop14 PF04147.12 ETO12976.1 - 1.9 6.6 18.2 2 6.5 18.2 1.0 1 0 0 1 1 1 0 Nop14-like family eIF-3c_N PF05470.12 ETO12976.1 - 2.1 6.5 10.3 2.5 6.3 10.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2457 PF10446.9 ETO12976.1 - 2.8 7.0 18.6 3.1 6.8 18.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) UvrA_DNA-bind PF17755.1 ETO12978.1 - 0.0026 18.1 0.0 0.0035 17.7 0.0 1.3 1 0 0 1 1 1 1 UvrA DNA-binding domain Arcadin_1 PF18653.1 ETO12978.1 - 0.018 15.1 0.2 2.1 8.5 0.0 2.2 2 0 0 2 2 2 0 Arcadin 1 ubiquitin PF00240.23 ETO12978.1 - 0.044 13.5 0.7 0.16 11.8 0.7 1.9 1 1 0 1 1 1 0 Ubiquitin family ACTL7A_N PF16840.5 ETO12978.1 - 0.17 11.9 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Actin-like protein 7A N-terminus TFIIA PF03153.13 ETO12980.1 - 0.00047 20.3 22.2 0.00057 20.0 22.2 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit RAB3GAP2_N PF14655.6 ETO12980.1 - 0.027 13.7 4.4 0.036 13.3 4.4 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Med3 PF11593.8 ETO12980.1 - 0.045 13.0 12.7 0.068 12.4 12.7 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Androgen_recep PF02166.16 ETO12980.1 - 1.3 7.7 15.1 1.9 7.2 15.1 1.3 1 0 0 1 1 1 0 Androgen receptor SprA-related PF12118.8 ETO12980.1 - 3.4 6.7 26.9 5 6.2 26.9 1.1 1 0 0 1 1 1 0 SprA-related family Presenilin PF01080.17 ETO12980.1 - 4.1 6.1 20.0 5 5.8 20.0 1.2 1 0 0 1 1 1 0 Presenilin DUF4551 PF15087.6 ETO12980.1 - 7.5 5.2 20.9 9.4 4.9 20.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Ndc1_Nup PF09531.10 ETO12980.1 - 9.6 4.8 13.6 11 4.5 13.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Fil_haemagg_2 PF13332.6 ETO12981.1 - 4.4e-05 23.7 32.0 0.014 15.5 2.1 5.4 2 2 1 4 4 4 3 Hemagglutinin repeat Bactofilin PF04519.13 ETO12981.1 - 1.9 8.8 11.2 0.36 11.1 0.3 4.2 4 1 2 6 6 6 0 Polymer-forming cytoskeletal Amino_oxidase PF01593.24 ETO12982.1 - 0.00011 21.7 0.0 0.12 11.7 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase Utp14 PF04615.13 ETO12983.1 - 0.63 8.5 64.9 0.84 8.1 64.9 1.1 1 0 0 1 1 1 0 Utp14 protein DUF4789 PF16033.5 ETO12984.1 - 0.028 14.9 1.3 0.028 14.9 1.3 2.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4789) Bromodomain PF00439.25 ETO12984.1 - 0.071 13.2 1.7 9 6.5 0.2 2.8 2 1 1 3 3 3 0 Bromodomain UBA_2 PF08587.11 ETO12984.1 - 0.36 11.0 1.5 1.1 9.5 1.0 2.1 1 1 1 2 2 2 0 Ubiquitin associated domain (UBA) Lipin_mid PF16876.5 ETO12984.1 - 0.85 9.8 6.6 0.67 10.1 1.8 2.3 2 0 0 2 2 2 0 Lipin/Ned1/Smp2 multi-domain protein middle domain Orthopox_B11R PF07033.11 ETO12984.1 - 2.3 8.1 6.9 5.9 6.7 0.1 3.2 2 2 2 4 4 4 0 Orthopoxvirus B11R protein DUF2165 PF09933.9 ETO12985.1 - 0.0022 18.0 13.6 0.093 12.8 0.1 2.6 1 1 0 2 2 2 2 Predicted small integral membrane protein (DUF2165) DUF996 PF06195.13 ETO12985.1 - 0.51 10.6 19.8 0.034 14.4 8.2 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF996) Orai-1 PF07856.12 ETO12985.1 - 0.98 9.1 9.1 71 3.0 0.0 2.9 2 1 0 2 2 2 0 Mediator of CRAC channel activity EloA-BP1 PF15870.5 ETO12986.1 - 0.14 12.4 5.4 0.17 12.2 5.4 1.2 1 0 0 1 1 1 0 ElonginA binding-protein 1 Adaptin_binding PF10199.9 ETO12986.1 - 0.52 10.9 7.1 0.39 11.3 5.8 1.5 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Pkinase PF00069.25 ETO12989.1 - 7.3e-10 38.7 0.4 1.5e-09 37.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12989.1 - 9.9e-05 21.7 0.0 0.00018 20.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Ndc1_Nup PF09531.10 ETO12989.1 - 0.0014 17.5 18.2 0.0016 17.2 18.2 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Macoilin PF09726.9 ETO12989.1 - 0.037 12.6 15.4 0.038 12.5 15.4 1.0 1 0 0 1 1 1 0 Macoilin family V_ATPase_I PF01496.19 ETO12989.1 - 0.076 10.9 5.9 0.079 10.9 5.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Apt1 PF10351.9 ETO12989.1 - 0.15 10.9 15.6 0.17 10.7 15.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Rib_5-P_isom_A PF06026.14 ETO12990.1 - 1e-50 171.7 0.0 1.4e-50 171.2 0.0 1.2 1 0 0 1 1 1 1 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) DeoRC PF00455.22 ETO12990.1 - 0.019 14.9 1.0 0.22 11.4 0.2 2.2 1 1 1 2 2 2 0 DeoR C terminal sensor domain Tudor-knot PF11717.8 ETO12992.1 - 2.7e-05 24.0 0.1 4.5e-05 23.3 0.1 1.3 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain PBP1_TM PF14812.6 ETO12992.1 - 0.016 15.6 0.2 0.031 14.6 0.2 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NST1 PF13945.6 ETO12992.1 - 1.3 9.1 13.0 1.7 8.7 13.0 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Orf78 PF06024.12 ETO12993.1 - 0.11 12.8 0.0 0.11 12.8 0.0 2.0 2 0 0 2 2 2 0 Orf78 (ac78) TPP_enzyme_C PF02775.21 ETO12994.1 - 1.5e-21 76.8 0.1 2.3e-21 76.2 0.1 1.3 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain DUF3021 PF11457.8 ETO12995.1 - 0.31 11.4 5.1 0.51 10.7 5.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) MFS_5 PF05631.14 ETO12996.1 - 1.7e-35 122.6 3.0 8.3e-27 94.0 0.9 2.0 1 1 1 2 2 2 2 Sugar-tranasporters, 12 TM TMEM213 PF15192.6 ETO12996.1 - 0.027 14.4 0.4 0.058 13.4 0.4 1.5 1 0 0 1 1 1 0 TMEM213 family Pkinase PF00069.25 ETO12997.1 - 1.2e-23 83.8 0.3 2e-23 83.1 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO12997.1 - 0.004 16.5 0.0 0.0091 15.3 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase GST_C_3 PF14497.6 ETO12999.1 - 0.0003 20.9 0.7 0.00067 19.8 0.0 1.9 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO12999.1 - 0.0017 18.5 0.6 0.0043 17.2 0.1 2.0 2 1 0 2 2 2 1 Glutathione S-transferase, C-terminal domain IclR PF01614.18 ETO13000.1 - 0.0019 18.0 0.4 0.003 17.4 0.4 1.3 1 0 0 1 1 1 1 Bacterial transcriptional regulator ArlS_N PF18719.1 ETO13000.1 - 0.1 12.8 2.3 1.9 8.7 0.1 2.2 2 0 0 2 2 2 0 ArlS sensor domain CobA_CobO_BtuR PF02572.15 ETO13002.1 - 0.022 15.0 0.1 0.043 14.1 0.1 1.5 1 0 0 1 1 1 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Na_Ala_symp PF01235.17 ETO13002.1 - 0.039 13.3 2.3 0.058 12.7 2.3 1.1 1 0 0 1 1 1 0 Sodium:alanine symporter family Heliorhodopsin PF18761.1 ETO13003.1 - 0.0025 17.2 0.2 0.0037 16.6 0.1 1.3 1 1 0 1 1 1 1 Heliorhodopsin VraX PF17412.2 ETO13003.1 - 0.038 13.6 1.1 0.28 10.8 0.2 2.3 2 0 0 2 2 2 0 Family of unknown function DEAD PF00270.29 ETO13004.1 - 9.8e-15 54.8 0.0 3.4e-14 53.0 0.0 1.9 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO13004.1 - 7.4e-10 39.1 0.0 7.4e-10 39.1 0.0 3.6 3 1 1 4 4 4 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO13004.1 - 2.6e-05 24.5 0.0 0.00011 22.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Ly-6_related PF06579.12 ETO13005.1 - 0.069 13.4 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Caenorhabditis elegans ly-6-related protein HATPase_c PF02518.26 ETO13007.1 - 1.5e-10 41.6 0.0 3.8e-10 40.2 0.0 1.7 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO13007.1 - 0.00016 21.5 0.0 0.00028 20.7 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase RcsC PF09456.10 ETO13007.1 - 0.023 14.7 0.0 0.056 13.4 0.0 1.7 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) BCDHK_Adom3 PF10436.9 ETO13008.1 - 2.6e-20 72.9 1.0 4.1e-20 72.3 1.0 1.2 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Pkinase PF00069.25 ETO13009.1 - 3.1e-57 193.9 0.9 9.6e-40 136.6 0.3 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13009.1 - 4.2e-31 108.2 0.2 1.1e-23 83.8 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO13009.1 - 1.4e-05 24.2 1.2 2.2e-05 23.6 1.2 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ETO13009.1 - 0.00013 21.4 2.4 0.02 14.2 0.0 3.3 3 1 1 4 4 4 2 Kinase-like Kdo PF06293.14 ETO13009.1 - 0.00013 21.4 0.0 0.00029 20.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO13009.1 - 0.026 14.5 0.1 0.026 14.5 0.1 1.9 2 1 0 2 2 2 0 Phosphotransferase enzyme family LMWPc PF01451.21 ETO13009.1 - 0.16 12.3 0.9 0.33 11.3 0.9 1.5 1 0 0 1 1 1 0 Low molecular weight phosphotyrosine protein phosphatase Pkinase_C PF00433.24 ETO13010.1 - 0.0028 18.3 0.0 0.0079 16.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase C terminal domain RRN3 PF05327.11 ETO13010.1 - 0.22 10.0 0.3 0.26 9.8 0.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Spc7 PF08317.11 ETO13011.1 - 7.3e-06 25.1 10.7 1.1e-05 24.5 10.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF4181 PF13789.6 ETO13011.1 - 0.028 14.7 2.1 0.028 14.7 2.1 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4181) Macoilin PF09726.9 ETO13011.1 - 0.11 11.1 7.7 0.19 10.2 7.7 1.4 1 0 0 1 1 1 0 Macoilin family Spc110_C PF18520.1 ETO13011.1 - 0.19 11.3 1.2 0.66 9.6 1.2 2.0 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain EMC3_TMCO1 PF01956.16 ETO13011.1 - 0.54 10.0 11.8 0.048 13.4 3.5 2.8 2 1 1 3 3 3 0 Integral membrane protein EMC3/TMCO1-like HU-CCDC81_bac_2 PF18175.1 ETO13011.1 - 3 7.8 0.0 3 7.8 0.0 3.8 4 1 0 4 4 4 0 CCDC81-like prokaryotic HU domain 2 Sec10 PF07393.11 ETO13012.1 - 6.5e-45 153.8 5.6 7.5e-45 153.6 5.6 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 HEPN-like_int PF18867.1 ETO13012.1 - 0.0062 16.4 0.0 0.019 14.8 0.0 1.8 1 0 0 1 1 1 1 HEPN-like integron domain Eaf7 PF07904.13 ETO13012.1 - 0.44 10.9 2.8 0.47 10.8 0.4 2.3 3 0 0 3 3 3 0 Chromatin modification-related protein EAF7 Sec10 PF07393.11 ETO13013.1 - 1.5e-05 23.7 0.9 1.8e-05 23.4 0.9 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF4704 PF15787.5 ETO13014.1 - 0.036 13.3 0.0 0.074 12.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4704) ATP-gua_PtransN PF02807.15 ETO13015.1 - 7.4e-06 26.3 0.0 2.5e-05 24.6 0.0 2.0 1 0 0 1 1 1 1 ATP:guanido phosphotransferase, N-terminal domain U79_P34 PF03064.16 ETO13015.1 - 0.00075 18.9 12.2 0.00075 18.9 12.2 3.7 4 0 0 4 4 4 1 HSV U79 / HCMV P34 Cwf_Cwc_15 PF04889.12 ETO13015.1 - 0.0087 15.8 14.1 0.0087 15.8 14.1 4.0 4 0 0 4 4 4 1 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 ETO13015.1 - 3.2 7.8 29.2 0.74 9.8 9.0 3.8 3 0 0 3 3 3 0 RXT2-like, N-terminal Alpha_kinase PF02816.18 ETO13016.1 - 0.00032 20.9 0.0 0.00071 19.8 0.0 1.5 1 1 0 1 1 1 1 Alpha-kinase family RNase_T PF00929.24 ETO13017.1 - 3e-05 24.6 0.2 3e-05 24.6 0.2 4.8 4 2 0 5 5 5 1 Exonuclease DUF4929 PF16283.5 ETO13017.1 - 5.7e-05 22.3 1.5 0.00011 21.3 1.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4929) Ku_C PF03730.14 ETO13017.1 - 0.0079 16.9 2.2 0.0079 16.9 2.2 4.6 5 0 0 5 5 5 2 Ku70/Ku80 C-terminal arm DUF4070 PF13282.6 ETO13017.1 - 0.018 15.2 1.9 0.041 14.0 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4070) WD40 PF00400.32 ETO13018.1 - 1.3e-07 32.2 6.6 0.00061 20.6 1.2 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat CDC45 PF02724.14 ETO13018.1 - 6.8 4.8 39.2 0.076 11.3 26.0 2.2 2 0 0 2 2 2 0 CDC45-like protein SIR2 PF02146.17 ETO13019.1 - 7e-10 39.1 1.2 1.2e-07 31.8 1.2 2.2 1 1 0 1 1 1 1 Sir2 family zf-TRAF PF02176.18 ETO13019.1 - 0.26 12.0 4.5 0.25 12.0 1.9 2.2 2 0 0 2 2 2 0 TRAF-type zinc finger DUF572 PF04502.13 ETO13020.1 - 4.9e-52 177.6 18.9 5.6e-52 177.4 18.9 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF572) DUF2730 PF10805.8 ETO13020.1 - 0.0061 16.6 1.4 0.018 15.1 1.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2730) Pkinase PF00069.25 ETO13021.1 - 1.6e-50 171.9 0.0 1.9e-50 171.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13021.1 - 2.6e-25 89.2 0.0 3.4e-25 88.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ETO13021.1 - 7.2e-06 26.6 0.5 1.3e-05 25.8 0.5 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ETO13021.1 - 0.0014 18.0 0.0 0.0016 17.8 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO13021.1 - 0.06 13.3 0.0 0.086 12.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO13021.1 - 0.11 11.2 0.0 0.16 10.7 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Inhibitor_Mig-6 PF11555.8 ETO13021.1 - 0.15 12.1 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 Corazonin PF17308.2 ETO13024.1 - 0.00051 20.4 4.9 0.00051 20.4 4.9 2.2 2 0 0 2 2 2 1 Pro-corazonin Secretin_N_2 PF07655.13 ETO13024.1 - 0.0054 17.2 12.7 0.0054 17.2 12.7 2.7 2 1 0 2 2 2 1 Secretin N-terminal domain MID_MedPIWI PF18296.1 ETO13024.1 - 0.12 12.1 4.2 1.3 8.7 0.5 2.4 2 0 0 2 2 2 0 MID domain of medPIWI Arm PF00514.23 ETO13026.1 - 2.5e-10 40.0 0.4 0.056 13.5 0.0 5.2 7 0 0 7 7 7 3 Armadillo/beta-catenin-like repeat CobT PF06213.12 ETO13026.1 - 0.026 13.9 3.0 0.044 13.2 3.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 ETO13026.1 - 0.099 12.3 3.8 0.2 11.3 3.8 1.4 1 0 0 1 1 1 0 FAM176 family PTPRCAP PF15713.5 ETO13026.1 - 0.23 11.7 4.5 0.45 10.8 4.5 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SDA1 PF05285.12 ETO13026.1 - 0.42 10.0 5.6 0.7 9.3 5.6 1.3 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 ETO13026.1 - 0.48 8.5 8.1 0.69 7.9 8.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi PI3K_1B_p101 PF10486.9 ETO13026.1 - 0.73 7.5 5.6 1.1 7.0 5.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GCIP PF13324.6 ETO13026.1 - 0.74 9.4 5.2 1.6 8.3 5.2 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF2457 PF10446.9 ETO13026.1 - 0.93 8.6 13.9 1.4 8.0 13.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 ETO13026.1 - 2.1 8.1 8.2 4.1 7.1 8.2 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO13026.1 - 3.6 6.8 15.8 6.8 5.9 15.8 1.3 1 0 0 1 1 1 0 NOA36 protein CAP_GLY PF01302.25 ETO13027.1 - 0.0044 17.0 0.0 0.0059 16.6 0.0 1.3 1 1 0 1 1 1 1 CAP-Gly domain ShK PF01549.24 ETO13028.1 - 0.003 18.1 4.8 0.0068 16.9 4.8 1.7 1 0 0 1 1 1 1 ShK domain-like Pkinase PF00069.25 ETO13029.1 - 6e-05 22.5 0.0 0.00016 21.1 0.0 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13029.1 - 0.0049 16.2 0.0 0.011 15.1 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO13030.1 - 6.6e-36 124.0 0.2 1.3e-16 60.8 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13030.1 - 1.3e-13 50.8 0.1 1.3e-08 34.4 0.1 2.7 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO13030.1 - 0.015 14.7 0.1 0.027 13.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ETO13030.1 - 0.052 12.5 0.2 0.085 11.8 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Coilin_N PF15862.5 ETO13030.1 - 0.062 13.1 4.0 0.14 11.9 4.0 1.6 1 0 0 1 1 1 0 Coilin N-terminus APH PF01636.23 ETO13030.1 - 0.15 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family FGF-BP1 PF06473.12 ETO13030.1 - 0.34 10.7 6.5 16 5.2 0.0 2.2 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Pkinase_fungal PF17667.1 ETO13030.1 - 1.7 7.3 6.8 0.41 9.4 0.1 2.1 1 1 0 2 2 2 0 Fungal protein kinase RGS PF00615.19 ETO13031.1 - 0.0003 21.1 0.9 0.00056 20.2 0.9 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain LUC7 PF03194.15 ETO13033.1 - 4.8e-05 23.2 4.1 4.8e-05 23.2 4.1 1.4 1 1 0 1 1 1 1 LUC7 N_terminus NOA36 PF06524.12 ETO13033.1 - 0.015 14.7 11.6 0.02 14.2 11.6 1.1 1 0 0 1 1 1 0 NOA36 protein DUF5308 PF17233.2 ETO13033.1 - 0.02 15.1 3.3 0.028 14.7 3.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5308) Rtf2 PF04641.12 ETO13033.1 - 0.025 13.9 8.9 0.031 13.6 8.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SLC12 PF03522.15 ETO13033.1 - 0.054 12.5 8.5 0.064 12.3 8.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 MID_MedPIWI PF18296.1 ETO13033.1 - 0.093 12.5 10.0 0.13 12.0 10.0 1.3 1 0 0 1 1 1 0 MID domain of medPIWI ALMT PF11744.8 ETO13033.1 - 0.11 11.4 7.4 0.12 11.1 7.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter UPF0565 PF10561.9 ETO13033.1 - 0.12 11.6 13.9 0.13 11.4 13.9 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0565 CSG2 PF16965.5 ETO13033.1 - 0.12 11.3 5.8 0.14 11.1 5.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CPSF100_C PF13299.6 ETO13033.1 - 0.52 10.5 5.1 0.67 10.1 5.1 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal NPR3 PF03666.13 ETO13033.1 - 0.68 8.7 12.4 0.79 8.4 12.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO13033.1 - 0.73 8.1 16.2 1 7.7 16.2 1.2 1 0 0 1 1 1 0 Menin Gti1_Pac2 PF09729.9 ETO13033.1 - 0.75 9.9 9.0 0.98 9.5 9.0 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family Tim54 PF11711.8 ETO13033.1 - 1 8.0 5.7 1.3 7.8 5.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Peroxin-13_N PF04088.13 ETO13033.1 - 2.9 8.1 7.4 24 5.2 7.4 2.1 1 1 0 1 1 1 0 Peroxin 13, N-terminal region Macoilin PF09726.9 ETO13033.1 - 4 5.9 13.7 4.7 5.6 13.7 1.1 1 0 0 1 1 1 0 Macoilin family DUF2076 PF09849.9 ETO13033.1 - 5.1 7.1 21.0 6.4 6.7 21.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) EOS1 PF12326.8 ETO13034.1 - 0.028 14.3 1.5 0.088 12.7 1.5 1.8 1 1 0 1 1 1 0 N-glycosylation protein Sporozoite_P67 PF05642.11 ETO13034.1 - 0.04 12.0 2.7 0.049 11.7 2.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2207 PF09972.9 ETO13034.1 - 0.041 12.7 9.4 0.45 9.2 1.9 2.0 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) FAM176 PF14851.6 ETO13034.1 - 0.056 13.1 1.5 0.098 12.3 1.5 1.5 1 0 0 1 1 1 0 FAM176 family Menin PF05053.13 ETO13034.1 - 0.095 11.1 8.7 0.13 10.6 8.7 1.1 1 0 0 1 1 1 0 Menin Peptidase_S49_N PF08496.10 ETO13034.1 - 0.12 12.4 0.0 0.12 12.4 0.0 2.6 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DUF2457 PF10446.9 ETO13034.1 - 0.25 10.5 8.3 0.35 10.0 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CSG2 PF16965.5 ETO13034.1 - 1.1 8.2 6.7 0.9 8.4 5.4 1.7 1 1 0 1 1 1 0 Ceramide synthase regulator Vfa1 PF08432.10 ETO13034.1 - 1.3 9.3 11.5 0.46 10.8 5.7 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Apis_Csd PF11671.8 ETO13034.1 - 1.6 8.7 12.6 1.1 9.3 10.5 1.8 2 0 0 2 2 2 0 Complementary sex determiner protein DUF2101 PF09874.9 ETO13034.1 - 3.8 7.2 9.0 0.2 11.3 2.6 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2101) DUF3402 PF11882.8 ETO13035.1 - 0.04 13.0 3.8 0.042 13.0 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) ALMT PF11744.8 ETO13035.1 - 0.71 8.6 8.2 0.79 8.5 8.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Menin PF05053.13 ETO13035.1 - 1.4 7.2 10.8 1.4 7.2 10.8 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO13035.1 - 4.9 5.8 6.0 5.2 5.7 6.0 1.2 1 0 0 1 1 1 0 Presenilin AAR2 PF05282.11 ETO13035.1 - 6.5 6.1 9.5 6.9 6.0 9.5 1.2 1 1 0 1 1 1 0 AAR2 protein Pkinase PF00069.25 ETO13036.1 - 3.9e-30 105.1 1.4 7.9e-30 104.1 1.4 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13036.1 - 7.3e-14 51.7 0.5 1.7e-13 50.4 0.5 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO13036.1 - 0.00051 19.5 0.0 0.00085 18.7 0.0 1.4 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO13036.1 - 0.0043 16.4 0.0 0.0072 15.7 0.0 1.2 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO13036.1 - 0.01 15.8 0.1 0.13 12.2 0.1 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO13036.1 - 0.053 12.5 0.1 0.08 11.9 0.1 1.3 1 1 0 1 1 1 0 Haspin like kinase domain WD40 PF00400.32 ETO13037.1 - 6.9e-24 83.7 14.9 2.2e-07 31.5 1.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13037.1 - 3e-07 30.6 0.1 0.011 16.0 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13037.1 - 1.9e-05 23.6 0.2 0.017 13.8 0.0 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO13037.1 - 0.0011 18.4 1.3 0.023 14.0 0.4 2.3 1 1 2 3 3 3 1 WD40-like domain DUF5096 PF17019.5 ETO13037.1 - 0.067 13.0 0.3 0.067 13.0 0.3 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5096) DSL PF01414.19 ETO13037.1 - 0.83 10.0 4.9 2 8.8 0.4 2.7 3 0 0 3 3 3 0 Delta serrate ligand AAA_31 PF13614.6 ETO13038.1 - 1.1e-57 194.8 1.3 1.8e-57 194.1 1.3 1.3 1 0 0 1 1 1 1 AAA domain CbiA PF01656.23 ETO13038.1 - 4.9e-23 81.6 0.1 7.4e-23 81.0 0.1 1.3 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain CBP_BcsQ PF06564.12 ETO13038.1 - 1.5e-11 44.2 0.0 4.8e-11 42.6 0.0 1.7 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ MipZ PF09140.11 ETO13038.1 - 1.8e-11 43.8 0.0 7.6e-11 41.8 0.0 1.8 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 ETO13038.1 - 1.6e-10 40.7 0.8 4.2e-10 39.3 0.4 2.0 1 1 0 2 2 2 1 Anion-transporting ATPase Fer4_NifH PF00142.18 ETO13038.1 - 2.9e-09 36.8 0.1 1.9e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family ParA PF10609.9 ETO13038.1 - 4.1e-09 36.3 0.4 2.1e-08 34.0 0.4 1.9 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase VirC1 PF07015.11 ETO13038.1 - 2.5e-05 23.7 0.0 0.0001 21.7 0.0 2.0 2 0 0 2 2 2 1 VirC1 protein MeaB PF03308.16 ETO13038.1 - 0.0066 15.5 0.1 0.012 14.6 0.1 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB ATP_bind_1 PF03029.17 ETO13038.1 - 0.04 13.7 0.3 0.17 11.7 0.1 2.2 2 1 0 2 2 2 0 Conserved hypothetical ATP binding protein PPS_PS PF02006.16 ETO13038.1 - 0.057 13.0 0.1 0.35 10.4 0.0 2.1 2 0 0 2 2 2 0 Phosphopantothenate/pantothenate synthetase SRP54 PF00448.22 ETO13038.1 - 0.079 12.6 0.1 0.22 11.1 0.1 1.7 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain CLP1_P PF16575.5 ETO13038.1 - 0.089 12.6 0.1 0.18 11.6 0.1 1.5 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop Methyltransf_24 PF13578.6 ETO13038.1 - 0.11 13.5 0.0 0.38 11.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Peptidase_C14 PF00656.22 ETO13039.1 - 4.7e-06 26.7 0.3 4.7e-06 26.7 0.3 1.7 2 0 0 2 2 2 1 Caspase domain Tti2 PF10521.9 ETO13039.1 - 0.046 13.2 1.1 0.075 12.6 1.1 1.3 1 0 0 1 1 1 0 Tti2 family RR_TM4-6 PF06459.12 ETO13039.1 - 0.062 13.1 9.3 0.098 12.5 9.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO13039.1 - 0.42 8.9 9.2 0.57 8.4 9.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Iwr1 PF08574.10 ETO13039.1 - 0.48 11.5 11.3 3.3 8.8 8.3 2.7 2 0 0 2 2 2 0 Transcription factor Iwr1 Sporozoite_P67 PF05642.11 ETO13039.1 - 1.9 6.5 6.1 2.9 5.9 6.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RPN2_C PF18004.1 ETO13039.1 - 3.1 7.7 12.8 6.1 6.7 12.8 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 ETO13039.1 - 5.3 6.7 12.6 14 5.4 12.6 1.6 1 0 0 1 1 1 0 FAM176 family CAP_GLY PF01302.25 ETO13040.1 - 1.9e-08 34.2 0.3 3e-08 33.5 0.3 1.3 1 0 0 1 1 1 1 CAP-Gly domain Aa_trans PF01490.18 ETO13041.1 - 1.9e-50 171.8 31.5 7e-49 166.6 31.5 2.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Abhydrolase_9_N PF15420.6 ETO13041.1 - 1.7 8.6 8.3 2.2 8.2 0.1 2.4 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus Aida_N PF08910.10 ETO13042.1 - 0.19 12.1 2.6 0.27 11.6 0.3 2.0 2 0 0 2 2 2 0 Aida N-terminus PH PF00169.29 ETO13043.1 - 0.00039 20.9 0.3 0.00092 19.7 0.3 1.6 1 0 0 1 1 1 1 PH domain PH_BEACH PF14844.6 ETO13045.1 - 1.3 9.2 7.3 8.8 6.5 0.6 2.4 2 0 0 2 2 2 0 PH domain associated with Beige/BEACH Sh_2 PF17512.2 ETO13046.1 - 0.0032 17.2 2.2 0.0067 16.2 2.2 1.5 1 0 0 1 1 1 1 Metapneumovirus Small hydrophobic protein DX PF01666.17 ETO13046.1 - 0.16 12.4 2.8 3.1 8.3 0.5 2.7 3 0 0 3 3 3 0 DX module VWA_2 PF13519.6 ETO13047.1 - 4.9e-11 43.2 0.2 1.8e-10 41.4 0.1 2.0 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETO13047.1 - 1.9e-10 41.3 0.8 3.2e-10 40.6 0.3 1.6 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO13047.1 - 3.8e-05 23.7 0.0 6.8e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Macoilin PF09726.9 ETO13048.1 - 8.4 4.8 8.7 12 4.3 8.7 1.2 1 0 0 1 1 1 0 Macoilin family DUF4485 PF14846.6 ETO13050.1 - 0.062 13.4 2.4 0.27 11.3 0.5 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4485) Exo84_C PF16528.5 ETO13051.1 - 1.2e-07 31.8 8.9 0.00021 21.2 0.4 3.8 2 1 1 4 4 4 3 Exocyst component 84 C-terminal Vps51 PF08700.11 ETO13051.1 - 0.0033 17.5 3.4 0.074 13.1 0.0 3.3 3 0 0 3 3 3 1 Vps51/Vps67 COG2 PF06148.11 ETO13051.1 - 0.0047 17.0 0.1 0.0047 17.0 0.1 3.2 4 0 0 4 4 4 1 COG (conserved oligomeric Golgi) complex component, COG2 M16C_assoc PF08367.11 ETO13053.1 - 6.2e-14 51.7 0.1 7.9e-14 51.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase M16C associated PA26 PF04636.13 ETO13053.1 - 0.02 13.9 0.1 0.02 13.8 0.1 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SID-1_RNA_chan PF13965.6 ETO13054.1 - 0.0021 16.6 3.0 0.0026 16.3 3.0 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 DDHD PF02862.17 ETO13054.1 - 0.0029 17.8 3.0 0.0032 17.7 3.0 1.1 1 0 0 1 1 1 1 DDHD domain DSPc PF00782.20 ETO13054.1 - 0.0048 16.7 0.0 0.0048 16.7 0.0 2.1 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain DUF1682 PF07946.14 ETO13054.1 - 0.006 15.8 7.8 0.0094 15.2 7.8 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) TFIIA PF03153.13 ETO13054.1 - 0.0066 16.5 18.2 0.0077 16.3 18.2 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SLC12 PF03522.15 ETO13054.1 - 0.034 13.2 13.7 0.042 12.9 13.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ETO13054.1 - 0.045 12.5 9.7 0.057 12.2 9.7 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO13054.1 - 0.053 13.4 8.4 0.069 13.0 8.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2722 PF10846.8 ETO13054.1 - 0.058 12.3 17.4 0.078 11.9 17.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Asparaginase_2 PF01112.18 ETO13054.1 - 0.081 11.9 4.0 0.11 11.5 4.0 1.2 1 0 0 1 1 1 0 Asparaginase RP-C_C PF11800.8 ETO13054.1 - 0.084 13.0 6.4 0.1 12.7 6.4 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4638 PF15472.6 ETO13054.1 - 0.12 12.1 8.9 0.16 11.7 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4638) MMR1 PF08505.10 ETO13054.1 - 0.19 12.0 15.1 0.25 11.6 15.1 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Serinc PF03348.15 ETO13054.1 - 0.27 10.1 1.6 0.34 9.8 1.6 1.4 1 0 0 1 1 1 0 Serine incorporator (Serinc) Neur_chan_memb PF02932.16 ETO13054.1 - 0.39 10.8 6.9 0.46 10.5 6.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PTPRCAP PF15713.5 ETO13054.1 - 0.39 11.0 9.8 0.53 10.6 9.8 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2052 PF09747.9 ETO13054.1 - 0.41 10.8 13.6 0.55 10.3 13.6 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Membralin PF09746.9 ETO13054.1 - 0.48 9.4 7.2 0.59 9.1 7.2 1.1 1 0 0 1 1 1 0 Tumour-associated protein Macoilin PF09726.9 ETO13054.1 - 0.48 8.9 12.5 0.58 8.7 12.5 1.0 1 0 0 1 1 1 0 Macoilin family TERB2 PF15101.6 ETO13054.1 - 0.59 10.1 9.9 0.77 9.8 9.9 1.3 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF4175 PF13779.6 ETO13054.1 - 0.63 7.9 16.2 0.7 7.7 16.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Androgen_recep PF02166.16 ETO13054.1 - 0.69 8.7 14.0 0.79 8.5 14.0 1.1 1 0 0 1 1 1 0 Androgen receptor CAML PF14963.6 ETO13054.1 - 0.82 9.7 7.3 1.4 9.0 7.3 1.3 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand TMEM51 PF15345.6 ETO13054.1 - 0.9 9.3 12.2 1.2 8.9 12.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 CPSF100_C PF13299.6 ETO13054.1 - 1 9.5 9.5 1.4 9.1 9.5 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 ETO13054.1 - 1 8.0 10.9 1.3 7.8 10.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CNDH2_M PF16869.5 ETO13054.1 - 1.3 9.7 10.9 1.8 9.2 10.9 1.2 1 0 0 1 1 1 0 PF16858 Zip PF02535.22 ETO13054.1 - 1.3 8.2 3.2 1.6 7.9 3.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 ETO13054.1 - 1.5 8.6 8.4 1.9 8.2 8.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ndc1_Nup PF09531.10 ETO13054.1 - 1.7 7.3 7.9 2 7.0 7.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CLN3 PF02487.17 ETO13054.1 - 1.7 7.6 6.6 2.3 7.2 6.6 1.2 1 0 0 1 1 1 0 CLN3 protein Di19_C PF14571.6 ETO13054.1 - 2.3 8.8 10.5 4.5 7.9 10.5 1.4 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal NST1 PF13945.6 ETO13054.1 - 2.8 8.0 23.2 3.9 7.5 23.2 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator UPF0560 PF10577.9 ETO13054.1 - 2.9 6.3 14.3 3.6 6.0 14.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 CobT PF06213.12 ETO13054.1 - 3 7.2 15.7 4 6.8 15.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT EIIBC-GUT_N PF03612.14 ETO13054.1 - 5.2 6.8 8.7 7.5 6.2 8.7 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SprA-related PF12118.8 ETO13054.1 - 6.9 5.7 21.0 8.8 5.4 21.0 1.1 1 0 0 1 1 1 0 SprA-related family Roughex PF06020.11 ETO13054.1 - 8.6 5.3 12.8 12 4.8 12.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Gti1_Pac2 PF09729.9 ETO13054.1 - 9.9 6.2 13.2 14 5.7 13.2 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family ALAD PF00490.21 ETO13055.1 - 2.3e-50 171.6 0.1 2.6e-50 171.4 0.1 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase ALAD PF00490.21 ETO13056.1 - 3.4e-44 151.3 0.0 8.2e-41 140.2 0.0 2.2 1 1 1 2 2 2 2 Delta-aminolevulinic acid dehydratase NACHT PF05729.12 ETO13057.1 - 0.0047 16.8 0.1 0.14 12.0 0.0 2.3 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ETO13057.1 - 0.013 15.8 0.5 0.21 11.8 0.5 2.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO13057.1 - 0.05 14.0 0.1 0.12 12.8 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF2796 PF10986.8 ETO13058.1 - 0.041 13.8 17.0 0.083 12.9 17.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Defb50 PF17546.2 ETO13058.1 - 0.084 12.8 0.2 0.21 11.5 0.2 1.6 1 0 0 1 1 1 0 Beta defensin 50 BcrAD_BadFG PF01869.20 ETO13059.1 - 0.043 13.3 0.0 0.068 12.7 0.0 1.3 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family C2 PF00168.30 ETO13060.1 - 7.6e-08 32.6 0.0 1.4e-07 31.7 0.0 1.4 1 0 0 1 1 1 1 C2 domain EF-hand_6 PF13405.6 ETO13062.1 - 0.00013 21.6 5.2 0.02 14.8 0.4 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO13062.1 - 0.0036 16.8 0.6 0.0036 16.8 0.6 3.5 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 ETO13062.1 - 0.039 13.8 0.2 0.039 13.8 0.2 3.5 2 2 1 3 3 3 0 EF-hand domain pair EF-hand_7 PF13499.6 ETO13062.1 - 0.048 14.1 0.8 0.048 14.1 0.8 2.9 1 1 1 3 3 3 0 EF-hand domain pair DUF2431 PF10354.9 ETO13063.1 - 1.2e-29 103.8 0.1 4e-29 102.0 0.1 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) TetR_C_37 PF18665.1 ETO13064.1 - 0.1 13.2 3.0 0.49 11.0 0.5 2.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Peptidase_M50 PF02163.22 ETO13064.1 - 0.14 11.4 0.1 0.26 10.5 0.1 1.4 1 0 0 1 1 1 0 Peptidase family M50 Astro_capsid_N PF03115.14 ETO13066.1 - 7.1 5.2 8.2 8.8 4.9 8.2 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor adh_short PF00106.25 ETO13067.1 - 9.9e-09 34.9 0.0 1.3e-08 34.6 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO13067.1 - 0.0056 16.3 0.0 0.0065 16.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Glyco_hydro_31 PF01055.26 ETO13068.1 - 5.7e-11 42.3 0.9 6.9e-11 42.0 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Rho_GDI PF02115.17 ETO13069.1 - 0.0031 17.3 0.0 0.0031 17.3 0.0 1.9 2 0 0 2 2 2 1 RHO protein GDP dissociation inhibitor Fibrinogen_BP PF08017.11 ETO13069.1 - 0.0073 14.8 1.0 0.0087 14.5 1.0 1.1 1 0 0 1 1 1 1 Fibrinogen binding protein Secretin_N_2 PF07655.13 ETO13069.1 - 0.026 15.1 2.3 0.026 15.1 2.3 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain Pkinase PF00069.25 ETO13070.1 - 5.4e-05 22.7 0.0 9.3e-05 21.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Ion_trans PF00520.31 ETO13072.1 - 3.9e-63 213.0 26.7 2e-35 122.2 3.4 2.1 2 0 0 2 2 2 2 Ion transport protein Ion_trans PF00520.31 ETO13073.1 - 1e-84 283.6 48.1 8.7e-43 146.3 21.3 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 ETO13073.1 - 1.7e-06 27.0 10.1 1.7e-06 27.0 10.1 5.2 5 1 1 6 6 6 3 Polycystin cation channel ABC1 PF03109.16 ETO13073.1 - 0.042 14.0 0.1 0.15 12.2 0.0 1.9 2 0 0 2 2 2 0 ABC1 family Neural_ProG_Cyt PF06567.11 ETO13073.1 - 0.13 12.5 0.0 0.28 11.4 0.0 1.5 1 0 0 1 1 1 0 Neural chondroitin sulphate proteoglycan cytoplasmic domain GPHH PF16905.5 ETO13073.1 - 0.14 11.9 0.0 0.33 10.8 0.0 1.6 1 0 0 1 1 1 0 Voltage-dependent L-type calcium channel, IQ-associated DUF4407 PF14362.6 ETO13074.1 - 0.0041 16.5 0.1 0.0041 16.5 0.1 3.3 1 1 3 4 4 4 1 Domain of unknown function (DUF4407) PRIMA1 PF16101.5 ETO13074.1 - 0.26 11.3 3.9 0.69 10.0 3.9 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF2353 PF09789.9 ETO13074.1 - 0.9 8.8 41.9 39 3.4 30.6 4.2 2 1 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) DUF1281 PF06924.11 ETO13074.1 - 1.1 8.7 3.3 2.4 7.7 3.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) HALZ PF02183.18 ETO13074.1 - 4.8 7.5 8.2 22 5.4 0.8 3.4 3 0 0 3 3 3 0 Homeobox associated leucine zipper TPR_MLP1_2 PF07926.12 ETO13074.1 - 5.5 7.1 45.7 0.41 10.7 23.7 3.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 ETO13074.1 - 7.2 6.8 41.3 0.57 10.4 9.6 4.4 3 1 1 4 4 4 0 JNK_SAPK-associated protein-1 Tubulin_C PF03953.17 ETO13075.1 - 2.9e-43 147.0 0.1 4.3e-43 146.5 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Laminin_G_3 PF13385.6 ETO13076.1 - 0.0049 17.0 0.1 0.0098 16.1 0.0 1.7 2 1 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily Pentaxin PF00354.17 ETO13076.1 - 0.044 13.5 0.0 0.052 13.2 0.0 1.3 1 0 0 1 1 1 0 Pentaxin family Syja_N PF02383.18 ETO13077.1 - 4e-43 148.0 5.4 1.2e-22 80.7 0.0 4.0 2 1 1 3 3 3 2 SacI homology domain Pox_Ag35 PF03286.14 ETO13077.1 - 0.0041 16.9 15.1 0.0092 15.8 15.1 1.5 1 0 0 1 1 1 1 Pox virus Ag35 surface protein CNDH2_C PF16858.5 ETO13077.1 - 0.0052 16.7 8.7 0.0077 16.1 8.7 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF913 PF06025.12 ETO13077.1 - 0.052 12.5 2.8 0.083 11.9 2.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO13077.1 - 0.092 11.9 4.7 0.15 11.2 4.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter OATP PF03137.20 ETO13077.1 - 0.14 10.5 0.2 0.22 9.7 0.2 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Tim54 PF11711.8 ETO13077.1 - 0.15 10.8 8.2 0.023 13.5 4.2 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SAPS PF04499.15 ETO13077.1 - 0.24 10.2 9.6 0.31 9.8 9.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein BORG_CEP PF14957.6 ETO13077.1 - 0.32 12.2 9.5 0.06 14.5 5.3 1.8 2 0 0 2 2 2 0 Cdc42 effector Presenilin PF01080.17 ETO13077.1 - 0.61 8.8 10.7 1.3 7.7 10.7 1.5 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO13077.1 - 0.62 8.2 21.0 0.99 7.5 21.0 1.2 1 0 0 1 1 1 0 Nop14-like family Ureide_permease PF07168.11 ETO13077.1 - 0.65 8.7 2.6 0.97 8.1 2.6 1.2 1 0 0 1 1 1 0 Ureide permease NARP1 PF12569.8 ETO13077.1 - 0.69 8.8 11.0 1.1 8.0 11.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SLC12 PF03522.15 ETO13077.1 - 1.3 8.0 10.2 2.1 7.2 10.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF789 PF05623.12 ETO13077.1 - 1.5 8.5 7.0 2.4 7.7 7.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF789) RR_TM4-6 PF06459.12 ETO13077.1 - 1.7 8.4 18.9 0.85 9.4 14.4 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO13077.1 - 2.3 6.4 18.4 3.5 5.8 18.4 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 ETO13077.1 - 3.3 7.4 18.4 0.59 9.8 14.9 1.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4637) Med19 PF10278.9 ETO13077.1 - 3.7 7.5 13.9 0.088 12.7 6.9 1.8 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 DUF1754 PF08555.10 ETO13077.1 - 4.2 8.2 29.6 4.1 8.3 27.0 2.0 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) MCM_bind PF09739.9 ETO13077.1 - 4.2 5.7 14.3 6.3 5.1 14.3 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Afi1 PF07792.12 ETO13077.1 - 5.1 7.6 18.9 5.2 7.5 15.4 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RRN3 PF05327.11 ETO13077.1 - 8.9 4.7 13.9 16 3.9 13.9 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cellulose_synt PF03552.14 ETO13077.1 - 9.1 4.6 7.5 13 4.1 7.5 1.1 1 0 0 1 1 1 0 Cellulose synthase BUD22 PF09073.10 ETO13077.1 - 9.8 5.4 26.0 22 4.2 26.1 1.5 1 1 0 1 1 1 0 BUD22 Tom22 PF04281.13 ETO13078.1 - 0.0088 15.8 0.6 0.013 15.2 0.6 1.3 1 0 0 1 1 1 1 Mitochondrial import receptor subunit Tom22 Radial_spoke_3 PF06098.11 ETO13078.1 - 0.028 13.7 0.9 0.031 13.5 0.9 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 GOLD_2 PF13897.6 ETO13078.1 - 0.035 14.6 1.3 0.052 14.0 1.3 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Vfa1 PF08432.10 ETO13078.1 - 0.28 11.5 7.9 0.35 11.2 7.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sec62 PF03839.16 ETO13078.1 - 5.5 6.4 6.0 6.7 6.1 6.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 UCH PF00443.29 ETO13079.1 - 3.2e-09 36.7 0.2 3.2e-09 36.7 0.2 3.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO13079.1 - 3.6e-05 23.5 0.3 3.6e-05 23.5 0.3 3.9 3 2 1 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase EF-hand_6 PF13405.6 ETO13079.1 - 0.0018 18.0 0.0 0.008 16.0 0.0 2.1 1 0 0 1 1 1 1 EF-hand domain BUD22 PF09073.10 ETO13079.1 - 0.027 13.8 24.2 0.055 12.8 24.2 1.4 1 0 0 1 1 1 0 BUD22 Connexin PF00029.19 ETO13079.1 - 0.59 9.8 6.8 0.2 11.4 0.8 2.5 2 0 0 2 2 2 0 Connexin Phage_Gp23 PF10669.9 ETO13079.1 - 1.2 9.5 12.0 0.027 14.8 2.9 2.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) DUF3439 PF11921.8 ETO13079.1 - 1.8 8.6 8.0 4.7 7.2 3.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Ctr PF04145.15 ETO13079.1 - 2.1 8.9 4.9 17 6.0 4.9 2.6 1 1 0 1 1 1 0 Ctr copper transporter family CPSF100_C PF13299.6 ETO13079.1 - 6.4 6.9 14.3 1.5 9.0 5.1 2.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal COMM_domain PF07258.14 ETO13081.1 - 2.9e-14 53.0 0.2 4.1e-14 52.4 0.2 1.3 1 0 0 1 1 1 1 COMM domain Dynein_AAA_lid PF17852.1 ETO13081.1 - 0.093 12.8 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain Nuc_sug_transp PF04142.15 ETO13082.1 - 1.3e-45 155.9 15.6 1.7e-45 155.6 15.6 1.1 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ETO13082.1 - 1.4e-07 31.8 25.7 7.3e-06 26.2 0.4 2.8 2 1 0 2 2 2 2 EamA-like transporter family Imm_superinfect PF14373.6 ETO13082.1 - 8.6 6.4 12.4 0.8 9.7 4.5 2.7 3 0 0 3 3 3 0 Superinfection immunity protein SPRY PF00622.28 ETO13083.1 - 0.00012 22.1 0.2 0.00095 19.3 0.2 2.2 1 1 0 1 1 1 1 SPRY domain SRCR PF00530.18 ETO13083.1 - 0.032 14.7 0.2 0.053 14.0 0.2 1.3 1 0 0 1 1 1 0 Scavenger receptor cysteine-rich domain AAA_11 PF13086.6 ETO13084.1 - 4.1e-49 167.7 3.3 2.8e-46 158.4 3.3 2.4 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO13084.1 - 4.4e-17 62.4 0.4 3.6e-16 59.5 0.2 2.3 2 1 0 2 2 1 1 AAA domain AAA_19 PF13245.6 ETO13084.1 - 3.1e-13 50.3 0.3 1e-11 45.4 0.1 2.4 2 1 0 2 2 2 1 AAA domain AAA_12 PF13087.6 ETO13084.1 - 6.9e-12 45.4 1.0 1.3e-11 44.5 0.5 1.8 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 ETO13084.1 - 8.1e-07 29.2 0.0 1.5e-06 28.3 0.0 1.5 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ETO13084.1 - 4.7e-06 26.3 0.1 0.002 17.7 0.0 2.3 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain DUF5599 PF18141.1 ETO13084.1 - 8.8e-06 25.9 0.1 2.8e-05 24.3 0.1 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF5599) DUF2075 PF09848.9 ETO13084.1 - 2.1e-05 24.0 2.0 0.0005 19.4 2.0 2.2 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) Helicase_RecD PF05127.14 ETO13084.1 - 3.4e-05 23.8 0.2 0.0001 22.2 0.2 2.0 1 1 0 1 1 1 1 Helicase PIF1 PF05970.14 ETO13084.1 - 9e-05 21.8 0.1 0.29 10.3 0.0 2.3 2 0 0 2 2 2 2 PIF1-like helicase PhoH PF02562.16 ETO13084.1 - 0.00049 19.6 0.1 0.0012 18.4 0.0 1.7 2 0 0 2 2 2 1 PhoH-like protein DEAD PF00270.29 ETO13084.1 - 0.00098 18.9 0.3 0.0023 17.7 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 ETO13084.1 - 0.0013 18.5 0.1 0.0068 16.2 0.0 2.0 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA PF00004.29 ETO13084.1 - 0.0022 18.4 0.0 0.0059 17.0 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO13084.1 - 0.0037 17.5 0.0 0.01 16.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ETO13084.1 - 0.0065 15.8 0.0 0.012 15.0 0.0 1.3 1 0 0 1 1 1 1 KaiC AAA_10 PF12846.7 ETO13084.1 - 0.0091 15.0 0.0 0.012 14.6 0.0 1.2 1 0 0 1 1 1 1 AAA-like domain T2SSE PF00437.20 ETO13084.1 - 0.013 14.6 0.0 0.029 13.4 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_16 PF13191.6 ETO13084.1 - 0.013 15.9 0.0 0.021 15.2 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ETO13084.1 - 0.014 15.4 0.0 0.032 14.2 0.0 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) SNF2_N PF00176.23 ETO13084.1 - 0.032 13.0 0.2 0.049 12.4 0.2 1.2 1 0 0 1 1 1 0 SNF2 family N-terminal domain SRP54 PF00448.22 ETO13084.1 - 0.037 13.6 0.2 0.15 11.7 0.1 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain NACHT PF05729.12 ETO13084.1 - 0.04 13.8 0.1 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 NACHT domain Sigma54_activat PF00158.26 ETO13084.1 - 0.059 13.1 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 ETO13084.1 - 0.062 13.0 0.1 0.15 11.8 0.1 1.7 1 1 0 1 1 1 0 IstB-like ATP binding protein AAA_23 PF13476.6 ETO13084.1 - 0.072 13.6 0.2 1.3 9.5 0.0 2.2 1 1 1 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ETO13084.1 - 0.074 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_34 PF13872.6 ETO13084.1 - 0.088 11.7 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 AAA_25 PF13481.6 ETO13084.1 - 0.11 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 ETO13084.1 - 0.11 12.4 0.1 0.25 11.3 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain VPS9 PF02204.18 ETO13085.1 - 2.8e-09 37.1 3.0 0.0002 21.5 0.4 2.5 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain PRESAN PF09687.10 ETO13085.1 - 0.0021 18.6 1.6 0.21 12.2 0.0 3.0 3 0 0 3 3 3 1 Plasmodium RESA N-terminal Orthoreo_P10 PF07204.11 ETO13085.1 - 0.077 13.0 0.3 0.18 11.8 0.3 1.6 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Phospholamban PF04272.14 ETO13085.1 - 3.4 7.2 5.3 0.76 9.3 1.0 2.1 2 0 0 2 2 2 0 Phospholamban FYVE PF01363.21 ETO13086.1 - 1.4e-11 44.3 15.5 1.4e-11 44.3 15.5 3.2 2 1 0 2 2 2 1 FYVE zinc finger FANCI_S3 PF14677.6 ETO13086.1 - 0.0032 17.2 0.1 0.048 13.4 0.1 2.4 2 0 0 2 2 2 1 FANCI solenoid 3 adh_short PF00106.25 ETO13087.1 - 8.8e-21 74.2 0.8 1e-20 74.0 0.8 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO13087.1 - 1e-13 51.4 0.1 1.3e-13 51.1 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase 3HCDH_N PF02737.18 ETO13087.1 - 0.0016 18.3 0.1 0.0031 17.4 0.1 1.4 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain KR PF08659.10 ETO13087.1 - 0.0023 17.9 0.2 0.0033 17.4 0.2 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_2 PF03446.15 ETO13087.1 - 0.0034 17.6 0.0 0.0085 16.3 0.0 1.6 1 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 ETO13087.1 - 0.011 15.4 0.1 0.017 14.8 0.1 1.4 1 1 0 1 1 1 0 Ketopantoate reductase PanE/ApbA RNA_pol_Rpb1_5 PF04998.17 ETO13087.1 - 0.21 11.0 1.9 0.27 10.6 1.9 1.1 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 AAA_12 PF13087.6 ETO13088.1 - 5.9e-59 199.0 0.2 7.1e-59 198.8 0.2 1.1 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ETO13088.1 - 0.00062 19.6 0.0 0.00083 19.2 0.0 1.2 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase UvrD_C_2 PF13538.6 ETO13088.1 - 0.00099 18.9 0.4 0.0061 16.4 0.0 2.5 3 1 0 3 3 3 1 UvrD-like helicase C-terminal domain Glyco_transf_28 PF03033.20 ETO13088.1 - 0.049 13.7 0.0 0.19 11.8 0.0 1.9 2 0 0 2 2 2 0 Glycosyltransferase family 28 N-terminal domain RGS PF00615.19 ETO13089.1 - 0.0082 16.4 0.9 0.012 15.8 0.0 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain Glyco_transf_25 PF01755.17 ETO13091.1 - 0.021 14.7 0.2 0.047 13.6 0.2 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 25 (LPS biosynthesis protein) Pkinase PF00069.25 ETO13092.1 - 3e-13 49.7 0.0 3.9e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_C PF00433.24 ETO13092.1 - 4.1e-06 27.4 2.1 8.6e-06 26.4 2.1 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase_Tyr PF07714.17 ETO13092.1 - 1.2e-05 24.7 0.0 1.6e-05 24.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO13094.1 - 0.00063 19.2 0.1 0.0011 18.4 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain GAGA_bind PF06217.12 ETO13094.1 - 1.1 9.4 13.5 2.4 8.4 4.7 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family Mucin PF01456.17 ETO13094.1 - 3.8 7.5 13.7 0.43 10.6 4.4 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein CDC45 PF02724.14 ETO13096.1 - 4.2e-05 22.1 8.1 6.4e-05 21.5 8.1 1.3 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO13096.1 - 9.4e-05 20.8 15.4 0.00014 20.3 15.4 1.1 1 0 0 1 1 1 1 Nop14-like family PPP4R2 PF09184.11 ETO13096.1 - 0.0037 16.9 12.3 0.007 16.0 12.3 1.5 1 0 0 1 1 1 1 PPP4R2 DUF5523 PF17661.1 ETO13096.1 - 0.011 15.5 14.2 0.021 14.5 14.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Nic96 PF04097.14 ETO13096.1 - 0.011 14.2 0.0 0.018 13.5 0.0 1.2 1 0 0 1 1 1 0 Nup93/Nic96 SDA1 PF05285.12 ETO13096.1 - 0.049 13.1 20.6 0.081 12.3 20.6 1.2 1 0 0 1 1 1 0 SDA1 SURF2 PF05477.11 ETO13096.1 - 0.06 13.0 9.6 0.12 12.0 9.6 1.6 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF31 PF01732.16 ETO13096.1 - 0.077 12.5 0.5 0.11 12.1 0.5 1.2 1 0 0 1 1 1 0 Putative peptidase (DUF31) Astro_capsid_p PF12226.8 ETO13096.1 - 0.081 12.1 8.5 0.11 11.6 8.5 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2722 PF10846.8 ETO13096.1 - 0.18 10.7 7.9 0.28 10.1 7.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Sporozoite_P67 PF05642.11 ETO13096.1 - 0.32 9.0 6.6 0.45 8.5 6.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BUD22 PF09073.10 ETO13096.1 - 0.35 10.2 16.3 0.37 10.1 15.4 1.4 2 0 0 2 2 2 0 BUD22 Mpp10 PF04006.12 ETO13096.1 - 0.38 9.1 23.1 0.57 8.6 23.1 1.2 1 0 0 1 1 1 0 Mpp10 protein NOA36 PF06524.12 ETO13096.1 - 0.43 9.8 22.7 1 8.6 22.7 1.6 1 0 0 1 1 1 0 NOA36 protein RR_TM4-6 PF06459.12 ETO13096.1 - 0.63 9.8 10.5 2 8.1 9.9 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RNA_pol_Rpc4 PF05132.14 ETO13096.1 - 0.73 10.3 5.0 1.5 9.2 5.0 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF3381 PF11861.8 ETO13096.1 - 0.75 9.6 19.5 2 8.2 19.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) RPA43_OB PF17875.1 ETO13096.1 - 0.82 10.3 4.8 1.9 9.1 4.8 1.6 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I PI3K_1B_p101 PF10486.9 ETO13096.1 - 1.3 6.7 10.6 1.9 6.1 10.6 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CPSF100_C PF13299.6 ETO13096.1 - 1.5 9.0 6.6 3.7 7.7 6.6 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 ETO13096.1 - 3.3 5.7 30.0 4.9 5.1 30.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO13096.1 - 3.6 6.3 5.0 5.4 5.7 5.0 1.3 1 0 0 1 1 1 0 Presenilin Radial_spoke PF04712.12 ETO13096.1 - 4 6.3 13.9 8.5 5.2 13.9 1.5 1 0 0 1 1 1 0 Radial spokehead-like protein TFB6 PF17110.5 ETO13096.1 - 6.5 6.5 11.3 13 5.5 11.3 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RNA_polI_A34 PF08208.11 ETO13096.1 - 6.7 6.7 15.5 14 5.8 15.5 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 PepSY_TM PF03929.16 ETO13097.1 - 4.7 6.8 10.6 14 5.2 10.6 1.8 1 0 0 1 1 1 0 PepSY-associated TM region HEAT PF02985.22 ETO13098.1 - 5.1e-08 32.5 0.3 4.7 7.8 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 ETO13098.1 - 0.00033 20.7 0.4 0.033 14.2 0.1 2.7 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETO13098.1 - 0.00036 19.2 2.9 0.00061 18.5 0.7 1.9 1 1 0 2 2 2 1 Adaptin N terminal region HEAT_2 PF13646.6 ETO13098.1 - 0.0032 17.8 0.0 0.37 11.2 0.0 2.6 2 1 0 2 2 2 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO13098.1 - 0.0068 17.0 0.2 0.11 13.1 0.0 2.4 2 1 1 3 3 3 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETO13098.1 - 0.011 15.9 0.4 0.51 10.5 0.0 2.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Proteasom_PSMB PF10508.9 ETO13098.1 - 0.012 14.1 1.9 0.026 13.1 0.0 2.0 1 1 0 2 2 2 0 Proteasome non-ATPase 26S subunit Caskin-Pro-rich PF16907.5 ETO13099.1 - 1.9 9.1 5.8 9.1 6.9 5.8 2.2 1 0 0 1 1 1 0 Proline rich region of Caskin proteins Pex14_N PF04695.13 ETO13099.1 - 7.6 7.2 10.7 17 6.0 1.4 2.6 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Exo_endo_phos PF03372.23 ETO13100.1 - 1.2e-06 28.2 0.0 2.2e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Myb_DNA-bind_7 PF15963.5 ETO13101.1 - 2e-26 91.7 1.8 2e-26 91.7 1.8 1.9 1 1 0 1 1 1 1 Myb DNA-binding like zf-FCS PF06467.14 ETO13101.1 - 0.069 13.1 5.8 4.4 7.3 6.3 2.7 1 1 1 2 2 2 0 MYM-type Zinc finger with FCS sequence motif zf-C2H2_4 PF13894.6 ETO13101.1 - 4.7 8.3 16.9 4.5 8.4 2.1 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger PseudoU_synth_2 PF00849.22 ETO13102.1 - 1.1e-18 67.8 11.2 2.1e-17 63.7 10.0 2.7 2 1 0 2 2 2 1 RNA pseudouridylate synthase SDA1 PF05285.12 ETO13102.1 - 0.00023 20.7 22.6 0.00023 20.7 22.6 2.1 2 0 0 2 2 2 1 SDA1 PPP4R2 PF09184.11 ETO13102.1 - 4.3 6.8 35.2 0.46 10.0 30.4 1.8 2 0 0 2 2 2 0 PPP4R2 Nop14 PF04147.12 ETO13102.1 - 5.7 5.0 37.6 0.42 8.8 32.6 1.6 2 0 0 2 2 2 0 Nop14-like family SURF2 PF05477.11 ETO13102.1 - 8.9 5.9 27.0 21 4.7 27.0 1.6 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SID-1_RNA_chan PF13965.6 ETO13103.1 - 0.38 9.1 4.1 0.41 9.0 4.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 ETO13103.1 - 0.63 8.7 14.6 0.81 8.4 14.6 1.3 1 0 0 1 1 1 0 Presenilin DUF4471 PF14740.6 ETO13103.1 - 1 8.5 12.4 1.4 8.0 12.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) EOS1 PF12326.8 ETO13103.1 - 1.2 9.1 3.7 2 8.3 3.7 1.5 1 0 0 1 1 1 0 N-glycosylation protein RR_TM4-6 PF06459.12 ETO13103.1 - 1.8 8.3 19.0 3.3 7.5 19.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 ETO13103.1 - 2.1 8.4 8.7 2.4 8.2 8.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3381 PF11861.8 ETO13103.1 - 5.9 6.7 24.4 10 5.9 24.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) tRNA-synt_1b PF00579.25 ETO13105.1 - 4.2e-34 118.2 0.0 2.2e-33 115.8 0.0 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (W and Y) Menin PF05053.13 ETO13107.1 - 0.019 13.4 0.2 0.029 12.8 0.2 1.2 1 0 0 1 1 1 0 Menin HEAT_2 PF13646.6 ETO13107.1 - 0.026 14.9 0.2 3.4 8.1 0.0 2.7 3 0 0 3 3 3 0 HEAT repeats Med31 PF05669.12 ETO13108.1 - 0.014 15.4 1.7 0.06 13.3 0.1 2.8 2 1 1 3 3 3 0 SOH1 IZUMO PF15005.6 ETO13108.1 - 5.9 7.4 12.9 0.18 12.3 3.6 3.2 3 2 1 4 4 4 0 Izumo sperm-egg fusion, Ig domain-associated Aminotran_1_2 PF00155.21 ETO13109.1 - 4e-06 26.2 0.0 5.2e-06 25.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II HEAT PF02985.22 ETO13111.1 - 9.4e-28 93.9 9.2 0.0025 17.9 0.0 9.1 9 0 0 9 9 9 8 HEAT repeat HEAT_2 PF13646.6 ETO13111.1 - 9.2e-18 64.4 10.7 3.5e-06 27.3 0.4 6.0 3 1 4 7 7 7 4 HEAT repeats Cnd1 PF12717.7 ETO13111.1 - 1e-09 38.7 8.8 0.08 13.0 0.0 5.9 2 1 4 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO13111.1 - 1.8e-07 31.7 1.4 0.0093 16.5 0.0 4.5 3 1 1 5 5 5 2 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ETO13111.1 - 1.7e-06 28.4 4.6 0.00016 22.1 0.0 5.2 6 0 0 6 6 6 1 HEAT-like repeat Adaptin_N PF01602.20 ETO13111.1 - 4.6e-06 25.5 6.0 0.00011 20.9 3.3 3.8 2 1 0 2 2 2 1 Adaptin N terminal region DUF4042 PF13251.6 ETO13111.1 - 0.00034 20.4 2.4 0.63 9.7 0.0 4.5 3 1 2 5 5 5 1 Domain of unknown function (DUF4042) CLASP_N PF12348.8 ETO13111.1 - 0.00059 19.5 1.0 0.45 10.1 0.0 4.0 3 1 1 4 4 4 1 CLASP N terminal TAF6_C PF07571.13 ETO13111.1 - 0.0008 19.7 0.3 0.085 13.2 0.0 3.5 3 1 0 3 3 3 1 TAF6 C-terminal HEAT repeat domain Cohesin_HEAT PF12765.7 ETO13111.1 - 0.004 17.4 0.3 11 6.4 0.0 5.5 6 0 0 6 6 6 1 HEAT repeat associated with sister chromatid cohesion RTP1_C1 PF10363.9 ETO13111.1 - 0.043 14.0 0.1 0.71 10.1 0.0 3.1 2 1 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Ran_BP1 PF00638.18 ETO13112.1 - 3.5e-12 46.6 2.0 3.5e-12 46.6 2.0 1.9 2 0 0 2 2 2 1 RanBP1 domain HPIH PF13323.6 ETO13112.1 - 1.2 9.0 9.1 0.1 12.5 2.5 2.6 2 1 0 2 2 2 0 N-terminal domain with HPIH motif Mago_nashi PF02792.14 ETO13112.1 - 1.4 9.0 6.3 1.3 9.1 1.0 2.4 1 1 0 2 2 2 0 Mago nashi protein DUF373 PF04123.13 ETO13113.1 - 0.012 15.1 3.3 0.016 14.6 3.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) Spo7 PF03907.13 ETO13113.1 - 0.11 11.9 2.5 0.12 11.8 1.7 1.4 1 1 0 1 1 1 0 Spo7-like protein YesK PF14150.6 ETO13113.1 - 0.45 10.8 6.2 0.76 10.0 1.0 2.4 1 1 1 2 2 2 0 YesK-like protein Tmemb_9 PF05434.11 ETO13113.1 - 1.9 8.4 8.5 3.6 7.5 0.5 2.3 1 1 1 2 2 2 0 TMEM9 ANAPC4_WD40 PF12894.7 ETO13114.1 - 6.1e-05 23.2 0.3 1.3 9.3 0.0 3.8 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain MVP_shoulder PF11978.8 ETO13114.1 - 0.074 13.1 0.6 1.3 9.0 0.1 2.6 2 0 0 2 2 2 0 Shoulder domain U71 PF17474.2 ETO13114.1 - 0.24 11.4 0.1 0.24 11.4 0.1 2.0 2 0 0 2 2 2 0 Tegument protein UL11 homolog Clathrin_lg_ch PF01086.17 ETO13115.1 - 1.6e-07 31.6 1.6 2e-07 31.3 1.6 1.2 1 1 0 1 1 1 1 Clathrin light chain Med22 PF06179.12 ETO13115.1 - 0.0071 16.5 2.7 0.017 15.3 2.7 1.7 1 1 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex DUF3501 PF12007.8 ETO13115.1 - 0.12 12.4 2.6 4.7 7.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3501) SUR7 PF06687.12 ETO13116.1 - 8.4 6.0 14.6 0.98 9.0 6.8 2.5 2 1 1 3 3 3 0 SUR7/PalI family ANAPC1 PF12859.7 ETO13116.1 - 8.9 6.9 10.5 33 5.0 0.1 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 SPRY PF00622.28 ETO13117.1 - 1.1e-12 48.2 0.6 1.9e-12 47.4 0.3 1.5 2 0 0 2 2 2 1 SPRY domain Neuralized PF07177.12 ETO13117.1 - 0.036 14.1 0.0 0.054 13.5 0.0 1.4 1 1 0 1 1 1 0 Neuralized BBP1_N PF15271.6 ETO13117.1 - 0.16 12.7 1.1 0.36 11.6 1.1 1.6 1 1 0 1 1 1 0 Spindle pole body component BBP1, Mps2-binding protein MMR_HSR1 PF01926.23 ETO13118.1 - 4.1e-16 59.1 0.0 1.6e-15 57.2 0.0 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO13118.1 - 1.4e-07 31.2 0.0 3.1e-07 30.1 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B IIGP PF05049.13 ETO13118.1 - 4.2e-05 22.8 0.0 6.6e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 ETO13118.1 - 0.00056 19.9 0.3 0.066 13.1 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ETO13118.1 - 0.00058 19.2 0.3 0.0035 16.7 0.0 2.2 2 0 0 2 2 2 1 AIG1 family Sporozoite_P67 PF05642.11 ETO13118.1 - 0.015 13.4 0.0 0.019 13.1 0.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AAA_18 PF13238.6 ETO13118.1 - 0.091 13.3 0.9 0.21 12.2 0.0 2.1 2 0 0 2 2 2 0 AAA domain Dynamin_N PF00350.23 ETO13118.1 - 0.099 12.7 0.7 1.1 9.3 0.0 2.8 3 1 1 4 4 4 0 Dynamin family CENP-B_dimeris PF09026.10 ETO13118.1 - 0.31 11.4 4.5 0.83 10.1 4.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain USP19_linker PF16602.5 ETO13119.1 - 8.3 7.0 12.9 5.6 7.6 2.6 3.3 2 1 0 3 3 3 0 Linker region of USP19 deubiquitinase PHD_2 PF13831.6 ETO13120.1 - 1.3e-11 43.9 4.3 4.7e-11 42.0 4.3 2.1 1 0 0 1 1 1 1 PHD-finger PHD PF00628.29 ETO13120.1 - 6.2e-09 35.6 7.5 2.5e-08 33.7 7.5 2.1 1 0 0 1 1 1 1 PHD-finger zf-HC5HC2H_2 PF13832.6 ETO13120.1 - 1.8e-07 31.3 0.8 1.8e-07 31.3 0.8 3.5 2 1 1 3 3 3 1 PHD-zinc-finger like domain Prok-RING_1 PF14446.6 ETO13120.1 - 0.0011 18.8 5.5 0.005 16.7 5.5 2.2 1 0 0 1 1 1 1 Prokaryotic RING finger family 1 zf-UDP PF14569.6 ETO13120.1 - 0.044 13.9 2.0 0.18 11.9 2.0 2.1 1 0 0 1 1 1 0 Zinc-binding RING-finger DUF664 PF04978.12 ETO13120.1 - 0.17 12.3 0.3 0.36 11.2 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF664) Macoilin PF09726.9 ETO13120.1 - 8.3 4.8 39.0 1.7 7.1 5.9 2.1 1 1 1 2 2 2 0 Macoilin family Pkinase PF00069.25 ETO13121.1 - 1.8e-25 89.8 2.0 9.6e-25 87.4 0.2 2.1 1 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13121.1 - 4.1e-14 52.5 0.4 9.1e-14 51.3 0.4 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pyrophosphatase PF00719.19 ETO13123.1 - 1.5e-40 138.6 0.4 4e-40 137.2 0.4 1.7 1 1 0 1 1 1 1 Inorganic pyrophosphatase CTD PF12815.7 ETO13125.1 - 0.06 13.9 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 Spt5 C-terminal nonapeptide repeat binding Spt4 AJAP1_PANP_C PF15298.6 ETO13126.1 - 0.1 12.8 5.3 0.65 10.2 0.1 2.2 2 0 0 2 2 2 0 AJAP1/PANP C-terminus RasGEF PF00617.19 ETO13127.1 - 1e-12 48.6 0.1 1.1e-12 48.5 0.1 1.0 1 0 0 1 1 1 1 RasGEF domain Sulf_coat_C PF12193.8 ETO13127.1 - 0.017 15.2 0.2 0.11 12.5 0.0 2.0 1 1 1 2 2 2 0 Sulfolobus virus coat protein C terminal WD40 PF00400.32 ETO13128.1 - 7.5e-56 184.8 19.9 1.9e-08 34.8 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13128.1 - 8.7e-21 74.0 7.0 6.8e-05 23.1 0.1 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO13128.1 - 3e-09 36.6 6.3 0.00054 19.4 0.1 4.7 2 1 3 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO13128.1 - 3.4e-09 35.9 4.1 0.2 10.3 0.1 5.3 2 2 2 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO13128.1 - 1.6e-08 33.9 4.1 0.85 8.5 0.0 5.9 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO13128.1 - 0.00071 18.2 2.6 0.014 14.0 0.1 2.6 2 1 1 3 3 3 1 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO13128.1 - 0.00083 18.3 0.0 0.12 11.2 0.0 3.0 2 1 2 4 4 4 3 Methylamine dehydrogenase heavy chain (MADH) BBS2_Mid PF14783.6 ETO13128.1 - 0.0049 16.9 3.8 7.2 6.7 0.1 4.6 2 2 1 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 ETO13128.1 - 0.01 15.8 1.6 12 6.0 0.1 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 ETO13128.1 - 0.012 14.7 0.1 0.54 9.3 0.0 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1513) DUF5570 PF17731.1 ETO13128.1 - 0.02 15.0 3.4 2.3 8.3 0.0 4.2 2 1 3 5 5 5 0 Family of unknown function (DUF5570) PQQ PF01011.21 ETO13128.1 - 0.034 14.1 0.0 1e+02 3.1 0.0 4.6 6 0 0 6 6 6 0 PQQ enzyme repeat PAN_3 PF08277.12 ETO13128.1 - 0.21 11.4 5.2 3.4 7.5 0.0 4.3 2 1 2 4 4 4 0 PAN-like domain DUF4064 PF13273.6 ETO13129.1 - 0.004 17.4 0.1 0.004 17.4 0.1 2.8 2 1 1 3 3 3 1 Protein of unknown function (DUF4064) GWT1 PF06423.12 ETO13129.1 - 0.18 12.0 2.3 0.35 11.0 2.3 1.5 1 1 1 2 2 2 0 GWT1 Peptidase_U4 PF03419.13 ETO13129.1 - 0.18 11.1 6.2 0.14 11.4 1.1 2.0 2 0 0 2 2 2 0 Sporulation factor SpoIIGA Halogen_Hydrol PF10112.9 ETO13129.1 - 4.1 7.4 4.7 6.8 6.7 1.7 2.0 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein zf-RING_2 PF13639.6 ETO13130.1 - 2.3e-11 43.8 11.0 4.9e-11 42.8 11.0 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO13130.1 - 3.7e-06 26.6 7.7 3.7e-06 26.6 7.7 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO13130.1 - 6.9e-06 25.8 7.9 1.5e-05 24.7 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO13130.1 - 9.6e-05 22.3 9.0 0.00011 22.1 7.3 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETO13130.1 - 0.00015 22.0 12.0 0.00073 19.8 12.0 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETO13130.1 - 0.00051 19.9 6.8 0.00094 19.0 6.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO13130.1 - 0.0058 16.5 9.0 0.016 15.1 9.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO13130.1 - 0.025 14.6 3.0 0.025 14.6 3.0 3.0 3 0 0 3 3 3 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 ETO13130.1 - 0.5 10.4 4.5 1.3 9.1 4.5 1.7 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETO13130.1 - 1.2 8.8 6.8 2.4 7.8 6.8 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Ank_2 PF12796.7 ETO13131.1 - 2.1e-08 34.7 0.0 0.0003 21.3 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO13131.1 - 1.3e-05 25.1 0.0 76 4.4 0.0 6.4 6 0 0 6 6 6 0 Ankyrin repeat Ank_4 PF13637.6 ETO13131.1 - 6.7e-05 23.4 0.0 11 6.8 0.0 4.4 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO13131.1 - 0.18 12.3 1.0 34 5.1 0.0 4.3 5 0 0 5 5 5 0 Ankyrin repeat ALMT PF11744.8 ETO13131.1 - 0.8 8.5 9.7 1.3 7.8 9.7 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter SUIM_assoc PF16619.5 ETO13131.1 - 6.1 7.0 13.2 0.088 12.9 2.6 3.0 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Mito_carr PF00153.27 ETO13132.1 - 1.1e-35 121.4 0.2 6.2e-23 80.6 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein zf-CCHC_2 PF13696.6 ETO13133.1 - 2.6e-16 59.1 37.8 1.4e-06 28.0 9.4 3.4 2 1 1 3 3 3 3 Zinc knuckle zf-CCHC PF00098.23 ETO13133.1 - 1.9e-10 40.3 17.6 0.00081 19.4 4.4 3.4 3 0 0 3 3 3 3 Zinc knuckle PUL PF08324.11 ETO13133.1 - 0.098 11.9 0.0 0.17 11.1 0.0 1.3 1 0 0 1 1 1 0 PUL domain zf-CCHC_3 PF13917.6 ETO13133.1 - 0.29 11.1 15.1 0.2 11.6 1.9 3.2 3 1 0 3 3 3 0 Zinc knuckle zf-CCHC_4 PF14392.6 ETO13133.1 - 2.1 8.2 14.2 1.5 8.6 2.1 3.1 2 1 1 3 3 3 0 Zinc knuckle Glyoxalase PF00903.25 ETO13134.1 - 4.9e-08 33.2 0.0 2.2e-07 31.1 0.0 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ETO13134.1 - 4.2e-06 27.0 0.0 1.3e-05 25.4 0.0 1.8 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_6 PF18029.1 ETO13134.1 - 0.022 15.6 0.0 0.057 14.2 0.0 1.6 1 1 0 1 1 1 0 Glyoxalase-like domain CfAFP PF05264.11 ETO13134.1 - 0.031 14.3 0.1 0.17 11.9 0.2 1.9 2 0 0 2 2 2 0 Choristoneura fumiferana antifreeze protein (CfAFP) DCB PF16213.5 ETO13135.1 - 3.8e-11 43.0 4.6 3.5e-10 39.8 2.9 2.8 1 1 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 ECM11 PF15463.6 ETO13135.1 - 0.14 12.7 2.6 0.31 11.6 2.6 1.6 1 1 0 1 1 1 0 Extracellular mutant protein 11 ASD2 PF08687.11 ETO13135.1 - 1.6 8.2 9.5 2.8 7.4 9.5 1.3 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Lin-8 PF03353.15 ETO13135.1 - 1.7 8.1 7.9 2.6 7.5 7.9 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist HECT PF00632.25 ETO13136.1 - 2.7e-89 299.7 0.0 4.7e-89 298.9 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) EcoRII-N PF09217.10 ETO13137.1 - 0.68 9.7 3.8 1.2 8.9 1.0 2.3 1 1 1 2 2 2 0 Restriction endonuclease EcoRII, N-terminal CAP_GLY PF01302.25 ETO13138.1 - 7.5e-18 64.3 0.4 1.4e-17 63.4 0.4 1.5 1 0 0 1 1 1 1 CAP-Gly domain Ras PF00071.22 ETO13139.1 - 3.8e-55 185.9 0.5 7.6e-55 184.9 0.5 1.5 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO13139.1 - 1.2e-29 102.9 1.9 1.8e-29 102.4 0.1 2.3 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO13139.1 - 9.3e-17 61.0 0.2 2.2e-16 59.8 0.2 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO13139.1 - 2.2e-06 27.7 0.0 9.8e-06 25.6 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ETO13139.1 - 0.017 15.5 0.0 0.066 13.6 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETO13139.1 - 0.018 15.3 0.0 0.078 13.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain Glutaminase PF04960.15 ETO13139.1 - 8 5.5 8.2 1.3 8.2 0.1 2.7 3 0 0 3 3 3 0 Glutaminase YMF19 PF02326.15 ETO13140.1 - 0.028 15.2 1.6 0.49 11.2 0.1 2.5 2 1 0 2 2 2 0 Plant ATP synthase F0 Lipase_GDSL_2 PF13472.6 ETO13142.1 - 0.015 15.7 0.1 0.028 14.8 0.1 1.5 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ETO13142.1 - 0.032 14.2 0.0 0.041 13.8 0.0 1.3 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase DUF2263 PF10021.9 ETO13144.1 - 1.9e-27 96.4 0.0 2.8e-25 89.4 0.0 2.4 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) TT_ORF1 PF02956.14 ETO13144.1 - 0.0013 17.5 0.5 0.002 16.9 0.5 1.3 1 0 0 1 1 1 1 TT viral orf 1 DUF4253 PF14062.6 ETO13144.1 - 0.046 13.9 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4253) PH_12 PF16457.5 ETO13144.1 - 0.073 13.6 2.1 0.2 12.2 2.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain PWWP PF00855.17 ETO13144.1 - 0.17 12.3 2.3 0.5 10.8 2.3 1.8 1 0 0 1 1 1 0 PWWP domain TPP_enzyme_C PF02775.21 ETO13145.1 - 1.9e-22 79.7 0.0 3.5e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ETO13145.1 - 2e-13 50.2 0.0 4.2e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain DUF2805 PF10985.8 ETO13145.1 - 0.068 13.6 0.5 0.14 12.5 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2805) AMP-binding PF00501.28 ETO13146.1 - 1.1e-61 208.8 0.2 1.2e-61 208.6 0.2 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Hydrolase_like PF13242.6 ETO13148.1 - 4.1e-17 62.0 0.0 6.3e-17 61.4 0.0 1.2 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ETO13148.1 - 0.14 12.4 0.0 0.16 12.3 0.0 1.1 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase DDHD PF02862.17 ETO13149.1 - 0.62 10.2 7.6 0.92 9.6 7.6 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO13149.1 - 2.4 6.8 7.4 2.8 6.6 7.4 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO13149.1 - 8.1 5.6 5.8 9 5.4 5.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Rad21_Rec8 PF04824.16 ETO13150.1 - 3.3e-10 39.1 0.0 7.2e-10 38.0 0.0 1.5 1 0 0 1 1 1 1 Conserved region of Rad21 / Rec8 like protein DUF2625 PF10946.8 ETO13151.1 - 0.27 10.3 2.6 0.57 9.2 2.6 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF2625 ADIP PF11559.8 ETO13151.1 - 0.38 10.8 28.2 1 9.5 0.9 2.9 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding DHR10 PF18595.1 ETO13151.1 - 0.44 10.6 29.5 0.29 11.2 1.8 3.2 3 1 0 3 3 3 0 Designed helical repeat protein 10 domain WD40_alt PF14077.6 ETO13151.1 - 0.65 9.9 4.1 10 6.1 0.2 3.4 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF4407 PF14362.6 ETO13151.1 - 0.66 9.3 18.6 5.6 6.2 14.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Rab5-bind PF09311.11 ETO13151.1 - 0.89 8.9 35.1 0.17 11.2 14.8 3.8 1 1 3 4 4 4 0 Rabaptin-like protein APG6_N PF17675.1 ETO13151.1 - 1.2 9.6 32.4 0.79 10.2 15.7 3.4 2 1 1 3 3 3 0 Apg6 coiled-coil region HTH_54 PF18607.1 ETO13151.1 - 1.7 8.7 8.4 0.63 10.1 0.6 2.8 2 1 0 2 2 2 0 ParA helix turn helix domain OmpH PF03938.14 ETO13151.1 - 4.3 7.7 23.6 26 5.1 19.5 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DASH_Dad2 PF08654.10 ETO13151.1 - 4.6 7.7 17.5 4.1 7.9 8.9 3.3 2 1 1 3 3 3 0 DASH complex subunit Dad2 SOGA PF11365.8 ETO13151.1 - 5.2 8.3 26.6 15 6.8 3.2 4.1 3 2 0 3 3 3 0 Protein SOGA ERM PF00769.19 ETO13151.1 - 5.3 6.8 31.9 0.29 10.9 15.9 2.5 2 1 0 2 2 2 0 Ezrin/radixin/moesin family ZapB PF06005.12 ETO13151.1 - 5.7 7.4 30.3 1.3 9.5 7.6 4.2 2 1 1 3 3 2 0 Cell division protein ZapB DUF1664 PF07889.12 ETO13151.1 - 8.6 6.4 16.0 1.2 9.2 1.4 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF1664 PF07889.12 ETO13152.1 - 0.029 14.4 2.4 0.029 14.4 2.4 3.6 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Vac7 PF12751.7 ETO13152.1 - 0.066 12.6 2.8 0.13 11.7 0.1 2.3 1 1 1 2 2 2 0 Vacuolar segregation subunit 7 Ald_Xan_dh_C PF01315.22 ETO13152.1 - 0.067 13.6 0.3 0.87 10.0 0.1 2.3 2 0 0 2 2 2 0 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain RGS PF00615.19 ETO13153.1 - 2.4e-07 31.0 0.1 8.8e-07 29.2 0.1 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain Peptidase_S49_N PF08496.10 ETO13154.1 - 0.012 15.7 1.3 0.65 10.0 0.1 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal BRF1 PF07741.13 ETO13154.1 - 0.032 14.6 5.4 0.58 10.5 0.2 2.1 2 0 0 2 2 2 0 Brf1-like TBP-binding domain PDCD7 PF16021.5 ETO13154.1 - 0.049 12.8 6.8 0.57 9.2 0.4 2.1 2 0 0 2 2 2 0 Programmed cell death protein 7 PVL_ORF50 PF07768.11 ETO13154.1 - 4.3 7.7 10.7 0.21 11.9 3.4 2.0 1 1 1 2 2 2 0 PVL ORF-50-like family zf-C2H2_2 PF12756.7 ETO13155.1 - 0.001 19.4 3.0 0.45 10.9 0.3 2.7 2 0 0 2 2 2 2 C2H2 type zinc-finger (2 copies) zf-Di19 PF05605.12 ETO13155.1 - 0.059 13.7 4.8 0.08 13.2 0.5 2.4 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ETO13155.1 - 0.087 13.7 12.7 0.15 13.0 2.9 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger SAM_1 PF00536.30 ETO13155.1 - 0.14 12.6 0.0 0.14 12.6 0.0 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) zf-C2H2_7 PF15269.6 ETO13155.1 - 0.37 10.9 2.2 0.7 10.0 0.5 2.1 2 0 0 2 2 2 0 Zinc-finger zf-BED PF02892.15 ETO13155.1 - 3.3 7.8 7.8 0.96 9.5 1.6 2.6 2 0 0 2 2 2 0 BED zinc finger DUF3226 PF11536.8 ETO13156.1 - 0.013 15.2 0.3 0.53 9.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3226) Sec62 PF03839.16 ETO13157.1 - 4.5 6.7 9.3 6.5 6.2 9.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 UBA PF00627.31 ETO13158.1 - 5.7e-07 29.3 0.0 1.3e-06 28.1 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain FliG_N PF14842.6 ETO13159.1 - 0.083 13.4 0.0 7.1 7.2 0.0 2.4 2 0 0 2 2 2 0 FliG N-terminal domain DUF1548 PF07579.11 ETO13159.1 - 0.77 10.1 3.4 2.1 8.7 0.7 2.8 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1548) AF-4 PF05110.13 ETO13160.1 - 0.054 11.6 29.2 0.054 11.6 29.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RR_TM4-6 PF06459.12 ETO13160.1 - 0.087 12.6 23.8 0.089 12.6 23.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EMC3_TMCO1 PF01956.16 ETO13160.1 - 0.095 12.4 5.0 0.13 12.0 5.0 1.3 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF4746 PF15928.5 ETO13160.1 - 0.15 11.5 16.0 0.17 11.3 16.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) GREB1 PF15782.5 ETO13160.1 - 0.74 6.9 10.2 0.69 7.0 10.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SAPS PF04499.15 ETO13160.1 - 0.84 8.3 12.2 0.91 8.2 12.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein FAM60A PF15396.6 ETO13160.1 - 1.2 9.1 21.8 1.4 8.9 21.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Neur_chan_memb PF02932.16 ETO13160.1 - 1.3 9.0 11.2 1.3 9.0 11.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2828 PF11443.8 ETO13160.1 - 2.1 6.4 16.1 2.6 6.0 16.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDC45 PF02724.14 ETO13160.1 - 2.6 6.2 22.9 2.9 6.1 22.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO13160.1 - 4.8 5.4 12.2 4.8 5.4 12.2 1.0 1 0 0 1 1 1 0 Menin Endostatin PF06482.11 ETO13160.1 - 5 6.5 12.0 6.1 6.2 12.0 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Presenilin PF01080.17 ETO13160.1 - 8.8 5.0 24.2 10 4.8 24.2 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO13160.1 - 9.9 4.8 25.9 13 4.4 25.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ac76 PF05814.11 ETO13161.1 - 0.0034 17.3 1.2 0.0034 17.3 1.2 3.2 4 0 0 4 4 4 1 Orf76 (Ac76) MFS_1 PF07690.16 ETO13161.1 - 0.0081 15.1 0.2 0.33 9.8 0.0 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily ABC2_membrane_3 PF12698.7 ETO13161.1 - 0.02 14.0 2.6 0.81 8.7 1.2 2.6 3 0 0 3 3 3 0 ABC-2 family transporter protein ETRAMP PF09716.10 ETO13161.1 - 4 7.6 7.7 4.5 7.4 5.2 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) bZIP_2 PF07716.15 ETO13162.1 - 0.12 12.5 0.2 0.12 12.5 0.2 3.4 3 1 0 3 3 3 0 Basic region leucine zipper K-box PF01486.17 ETO13162.1 - 0.52 10.5 14.3 0.032 14.4 8.5 2.1 2 1 0 2 2 2 0 K-box region CC2-LZ PF16516.5 ETO13162.1 - 3.9 7.9 18.5 0.13 12.7 1.1 3.3 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator CIAPIN1 PF05093.13 ETO13162.1 - 9.1 6.9 14.5 3.3 8.3 11.4 1.9 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Ribosomal_60s PF00428.19 ETO13163.1 - 0.027 15.1 5.6 0.052 14.1 5.6 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Peptidase_S64 PF08192.11 ETO13163.1 - 3.7 5.9 19.0 4.1 5.8 19.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 VIT1 PF01988.19 ETO13164.1 - 0.037 13.9 0.0 0.045 13.6 0.0 1.1 1 0 0 1 1 1 0 VIT family RasGAP PF00616.19 ETO13164.1 - 0.058 13.1 1.0 0.071 12.8 1.0 1.2 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase Cwf_Cwc_15 PF04889.12 ETO13164.1 - 0.07 12.9 11.2 0.084 12.6 11.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETO13164.1 - 0.19 11.0 6.7 0.26 10.6 6.7 1.2 1 0 0 1 1 1 0 NOA36 protein GOLD_2 PF13897.6 ETO13164.1 - 0.24 11.9 8.0 0.64 10.5 8.0 1.6 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking RRN3 PF05327.11 ETO13164.1 - 0.33 9.5 2.9 0.34 9.4 2.9 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4637 PF15470.6 ETO13164.1 - 0.44 10.3 6.6 0.58 9.9 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 ETO13164.1 - 0.96 7.7 9.6 1.1 7.4 9.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO13164.1 - 1 7.4 4.6 1 7.4 4.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PI3K_1B_p101 PF10486.9 ETO13164.1 - 2.1 6.1 4.3 2.4 5.9 4.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RVT_1 PF00078.27 ETO13165.1 - 0.0068 15.9 0.1 0.0099 15.4 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) rve PF00665.26 ETO13166.1 - 2.3e-08 34.3 0.1 3.1e-08 33.8 0.1 1.2 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 ETO13166.1 - 7.4e-06 25.7 0.0 1e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain NADH_B2 PF14813.6 ETO13169.1 - 0.34 10.7 2.6 0.3 10.9 0.7 1.9 2 0 0 2 2 2 0 NADH dehydrogenase 1 beta subcomplex subunit 2 RT_RNaseH_2 PF17919.1 ETO13170.1 - 1.7e-08 34.4 0.0 3.7e-08 33.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETO13170.1 - 3.3e-05 24.1 0.1 0.00017 21.8 0.0 2.1 2 1 0 2 2 2 1 RNase H-like domain found in reverse transcriptase KxDL PF10241.9 ETO13170.1 - 0.083 13.2 1.9 0.1 12.9 0.5 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein WD40 PF00400.32 ETO13171.1 - 2.3e-59 195.9 17.4 7.4e-09 36.1 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13171.1 - 6.9e-25 87.2 0.4 0.0033 17.7 0.0 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13171.1 - 9.3e-17 61.0 0.2 0.037 13.0 0.0 6.7 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO13171.1 - 6.7e-12 45.0 13.9 0.34 10.9 0.0 7.4 7 0 0 7 7 7 4 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO13171.1 - 4.2e-10 39.8 0.1 0.00083 19.3 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO13171.1 - 4e-08 32.9 1.3 0.0038 16.6 0.0 2.8 1 1 1 2 2 2 2 WD40-like domain DPPIV_N PF00930.21 ETO13171.1 - 9e-06 24.7 0.3 0.032 13.0 0.0 4.7 2 2 3 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nbas_N PF15492.6 ETO13171.1 - 2.2e-05 23.9 2.7 0.0018 17.7 0.1 3.9 2 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO13171.1 - 0.00037 19.3 1.4 0.25 10.0 0.0 3.5 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO13171.1 - 0.00077 19.5 0.1 5.7 7.1 0.0 5.0 4 3 2 6 6 6 1 Strictosidine synthase DUF2963 PF11178.8 ETO13171.1 - 0.001 18.7 0.1 13 5.6 0.2 5.2 5 1 1 6 6 6 0 Protein of unknown function (DUF2963) Cytochrom_D1 PF02239.16 ETO13171.1 - 0.0059 15.2 0.0 0.12 10.9 0.0 2.3 2 0 0 2 2 2 1 Cytochrome D1 heme domain SGL PF08450.12 ETO13171.1 - 0.011 15.3 0.1 6.6 6.2 0.0 3.0 1 1 2 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region Coatomer_WDAD PF04053.14 ETO13171.1 - 0.032 13.3 0.2 2 7.4 0.1 2.6 1 1 2 3 3 3 0 Coatomer WD associated region DUF5449 PF17528.2 ETO13171.1 - 0.043 13.6 0.2 20 4.9 0.0 3.2 1 1 2 3 3 3 0 Family of unknown function (DUF5449) Resistin PF06954.11 ETO13171.1 - 0.05 14.2 0.5 31 5.2 0.0 3.7 3 1 0 3 3 3 0 Resistin Proteasome_A_N PF10584.9 ETO13171.1 - 0.21 11.3 16.5 14 5.5 0.1 6.8 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO13172.1 - 7.5e-06 26.6 0.0 0.0023 18.8 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat LisH_TPL PF17814.1 ETO13172.1 - 6.8e-05 22.4 0.1 0.00012 21.6 0.1 1.4 1 0 0 1 1 1 1 LisH-like dimerisation domain DUF1771 PF08590.10 ETO13175.1 - 0.0023 18.3 4.2 0.005 17.2 4.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) SpecificRecomb PF10136.9 ETO13175.1 - 0.043 12.1 0.4 0.046 12.0 0.4 1.1 1 0 0 1 1 1 0 Site-specific recombinase CSTF2_hinge PF14327.6 ETO13175.1 - 0.06 13.8 0.1 0.18 12.3 0.1 1.8 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 MFP2b PF12150.8 ETO13175.1 - 0.068 12.5 1.0 0.12 11.6 0.4 1.7 2 0 0 2 2 2 0 Cytosolic motility protein DUF4398 PF14346.6 ETO13175.1 - 0.07 13.8 7.4 0.072 13.7 1.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4398) FlgN PF05130.12 ETO13175.1 - 2.4 8.7 9.7 0.59 10.6 0.1 2.7 2 1 1 3 3 3 0 FlgN protein Kinesin PF00225.23 ETO13176.1 - 3.7e-17 62.3 5.4 2e-15 56.6 0.4 2.3 2 1 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ETO13176.1 - 2.6e-11 43.7 6.1 1.8e-10 40.9 0.4 2.4 2 1 0 2 2 2 2 Microtubule binding YwhD PF08741.10 ETO13176.1 - 0.019 14.7 0.4 0.026 14.2 0.4 1.2 1 0 0 1 1 1 0 YwhD family Kinesin PF00225.23 ETO13177.1 - 2.7e-41 141.6 1.0 2.7e-41 141.6 1.0 4.8 4 2 1 5 5 5 1 Kinesin motor domain Cnn_1N PF07989.11 ETO13177.1 - 0.0003 20.9 3.8 0.0003 20.9 3.8 6.9 5 3 1 6 6 6 2 Centrosomin N-terminal motif 1 Pribosyltran_N PF13793.6 ETO13177.1 - 0.036 14.0 0.2 3.8 7.5 0.0 2.6 2 0 0 2 2 2 0 N-terminal domain of ribose phosphate pyrophosphokinase Secretin_N_2 PF07655.13 ETO13177.1 - 0.07 13.7 20.3 0.089 13.4 4.5 2.8 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3439 PF11921.8 ETO13178.1 - 0.7 9.9 5.1 1.5 8.8 5.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Kelch_6 PF13964.6 ETO13179.1 - 0.056 13.7 0.4 0.96 9.8 0.1 3.0 3 1 1 4 4 4 0 Kelch motif Arm PF00514.23 ETO13180.1 - 4.3e-07 29.8 0.1 8.9e-06 25.6 0.0 2.8 2 1 1 3 3 3 1 Armadillo/beta-catenin-like repeat IBB PF01749.20 ETO13180.1 - 0.00042 20.7 7.3 0.00099 19.5 4.7 2.3 2 0 0 2 2 2 1 Importin beta binding domain OAD_gamma PF04277.13 ETO13181.1 - 0.049 14.2 5.2 3.9 8.1 0.6 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain CENP-B_dimeris PF09026.10 ETO13181.1 - 0.41 11.1 5.4 0.82 10.1 5.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF1738 PF08401.11 ETO13181.1 - 0.78 9.8 5.6 9.1 6.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1738) DUF262 PF03235.14 ETO13181.1 - 3.1 7.9 9.4 6.5 6.9 8.7 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF262 Use1 PF09753.9 ETO13181.1 - 3.2 7.4 18.0 0.42 10.3 13.6 1.6 1 1 1 2 2 2 0 Membrane fusion protein Use1 Presenilin PF01080.17 ETO13181.1 - 5.1 5.8 7.2 7.4 5.2 7.2 1.3 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO13182.1 - 2.8e-05 24.8 0.3 0.043 14.7 0.1 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 ETO13183.1 - 2.5e-38 129.4 29.8 7.5e-07 29.8 0.5 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13183.1 - 2.9e-13 49.9 7.0 0.0039 17.4 0.1 5.7 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO13183.1 - 1.7e-05 25.4 4.0 1.7e-05 25.4 4.0 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger Secretin_N_2 PF07655.13 ETO13183.1 - 1.1 9.9 27.5 0.11 13.0 14.6 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain Mvb12 PF09452.10 ETO13184.1 - 1.8 9.0 5.6 1.8 9.1 1.9 2.6 2 1 0 2 2 2 0 ESCRT-I subunit Mvb12 FragX_IP PF05994.11 ETO13186.1 - 1.1e-155 520.0 12.2 3.6e-89 299.9 10.7 3.4 3 1 0 3 3 3 2 Cytoplasmic Fragile-X interacting family CobT PF06213.12 ETO13186.1 - 0.0021 17.5 16.5 0.0036 16.7 16.5 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DDHD PF02862.17 ETO13186.1 - 0.063 13.4 5.9 0.25 11.5 5.5 2.1 2 0 0 2 2 2 0 DDHD domain DUF2052 PF09747.9 ETO13186.1 - 0.071 13.2 16.8 0.13 12.3 16.8 1.4 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Borrelia_P83 PF05262.11 ETO13186.1 - 0.11 11.0 21.3 0.17 10.3 21.3 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein CDC45 PF02724.14 ETO13186.1 - 0.26 9.6 11.9 0.41 8.9 11.9 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4776 PF16003.5 ETO13186.1 - 0.34 9.9 19.1 0.36 9.8 14.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4776) CPSF100_C PF13299.6 ETO13186.1 - 0.62 10.2 12.1 4.6 7.4 12.1 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Neur_chan_memb PF02932.16 ETO13186.1 - 0.98 9.4 9.8 2.1 8.4 9.8 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO13186.1 - 1 8.5 4.7 1.7 7.8 4.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO13186.1 - 1.4 7.6 15.4 2.6 6.7 15.4 1.3 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 ETO13186.1 - 1.5 7.8 9.3 3.2 6.7 9.3 1.5 1 0 0 1 1 1 0 CLN3 protein Afi1 PF07792.12 ETO13186.1 - 7.1 7.1 15.7 20 5.7 15.7 1.8 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM60A PF15396.6 ETO13186.1 - 8.3 6.4 16.1 1.2 9.1 11.6 1.8 2 0 0 2 2 2 0 Protein Family FAM60A DDRGK PF09756.9 ETO13186.1 - 9.1 5.8 33.8 20 4.7 33.8 1.5 1 0 0 1 1 1 0 DDRGK domain Malate_synthase PF01274.22 ETO13187.1 - 0.0098 14.2 0.0 0.014 13.7 0.0 1.1 1 0 0 1 1 1 1 Malate synthase PPDFL PF15060.6 ETO13188.1 - 0.053 14.0 9.0 2.5 8.6 0.6 2.5 1 1 1 2 2 2 0 Differentiation and proliferation regulator FpoO PF10621.9 ETO13188.1 - 0.2 12.0 2.1 0.87 9.9 0.1 2.3 2 0 0 2 2 2 0 F420H2 dehydrogenase subunit FpoO EIF4E-T PF10477.9 ETO13189.1 - 0.0046 15.8 2.3 0.005 15.7 2.3 1.0 1 0 0 1 1 1 1 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E DUF4239 PF14023.6 ETO13189.1 - 0.026 14.3 2.4 0.036 13.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) SIMPL PF04402.14 ETO13189.1 - 0.038 14.4 1.2 0.048 14.1 1.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF541) OmpH PF03938.14 ETO13189.1 - 0.047 14.0 6.3 0.067 13.5 6.3 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Prominin PF05478.11 ETO13189.1 - 0.048 11.6 4.0 0.048 11.6 4.0 1.1 1 0 0 1 1 1 0 Prominin DUF3583 PF12126.8 ETO13189.1 - 0.048 13.1 5.3 0.059 12.8 5.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3583) Baculo_PEP_C PF04513.12 ETO13189.1 - 0.059 13.4 1.3 0.099 12.7 1.3 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tai4 PF16695.5 ETO13189.1 - 0.071 13.6 0.7 0.2 12.2 0.4 1.8 1 1 1 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein PH_3 PF14593.6 ETO13189.1 - 0.083 13.0 1.8 0.15 12.2 1.8 1.4 1 0 0 1 1 1 0 PH domain Atg14 PF10186.9 ETO13189.1 - 0.12 11.4 6.8 0.15 11.1 6.8 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 SKA2 PF16740.5 ETO13189.1 - 0.14 11.9 8.5 0.6 9.9 7.0 2.5 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF1043 PF06295.12 ETO13189.1 - 0.22 11.5 6.8 0.39 10.7 6.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) UPF0242 PF06785.11 ETO13189.1 - 0.24 11.5 9.1 0.37 10.9 9.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus ARA70 PF12489.8 ETO13189.1 - 0.33 11.1 5.7 0.92 9.7 5.7 1.8 1 1 0 1 1 1 0 Nuclear coactivator MitMem_reg PF13012.6 ETO13189.1 - 0.76 10.2 4.8 7.4 7.0 4.8 2.2 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function Exonuc_VII_L PF02601.15 ETO13189.1 - 0.77 9.3 5.3 0.94 9.0 5.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETO13189.1 - 1.3 9.1 6.8 2 8.4 3.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) FlxA PF14282.6 ETO13189.1 - 1.4 9.0 10.8 8.4 6.5 10.8 1.9 1 1 1 2 2 2 0 FlxA-like protein TLD PF07534.16 ETO13190.1 - 7.5e-06 26.2 0.0 1.3e-05 25.5 0.0 1.4 1 0 0 1 1 1 1 TLD BUD22 PF09073.10 ETO13190.1 - 0.0014 18.0 24.0 0.0019 17.6 24.0 1.1 1 0 0 1 1 1 1 BUD22 Cwf_Cwc_15 PF04889.12 ETO13190.1 - 0.0033 17.2 29.2 0.0047 16.7 29.2 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Pox_Ag35 PF03286.14 ETO13190.1 - 0.0048 16.7 17.1 0.0085 15.9 17.1 1.4 1 0 0 1 1 1 1 Pox virus Ag35 surface protein PPP4R2 PF09184.11 ETO13190.1 - 0.11 12.1 18.7 0.2 11.2 18.7 1.4 1 0 0 1 1 1 0 PPP4R2 Zip PF02535.22 ETO13190.1 - 0.35 10.0 5.2 0.47 9.6 5.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO13190.1 - 0.59 8.9 10.1 0.73 8.5 10.1 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO13190.1 - 1 8.3 7.8 1.4 7.8 7.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 ETO13190.1 - 1.9 6.9 11.9 2.8 6.4 11.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 V_ATPase_I PF01496.19 ETO13190.1 - 2.9 5.7 6.8 4 5.2 6.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF2828 PF11443.8 ETO13190.1 - 3.1 5.8 12.3 4.4 5.3 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Astro_capsid_p PF12226.8 ETO13190.1 - 3.3 6.8 10.0 4.9 6.2 10.0 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Neur_chan_memb PF02932.16 ETO13190.1 - 4 7.4 6.1 6.4 6.8 6.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 ETO13190.1 - 4.3 5.4 11.4 6 4.9 11.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein FAM60A PF15396.6 ETO13190.1 - 5 7.1 17.3 9.7 6.1 17.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A OAD_gamma PF04277.13 ETO13190.1 - 5.6 7.6 8.7 18 6.0 8.7 1.9 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain PNISR PF15996.5 ETO13190.1 - 6.3 7.0 27.5 9.4 6.5 27.5 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Pes-10 PF07149.11 ETO13190.1 - 7.4 5.5 11.6 10 5.0 11.6 1.3 1 0 0 1 1 1 0 Pes-10 Pkinase PF00069.25 ETO13191.1 - 6.1e-07 29.1 0.1 8.5e-07 28.6 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain Protocadherin PF08374.11 ETO13191.1 - 0.19 11.7 0.9 0.22 11.5 0.9 1.1 1 0 0 1 1 1 0 Protocadherin DUF4599 PF15371.6 ETO13192.1 - 0.074 13.6 0.9 0.52 10.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4599) Afi1 PF07792.12 ETO13192.1 - 5 7.6 12.0 3.7 8.0 2.6 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking E7 PF00527.18 ETO13192.1 - 7.8 6.8 8.4 0.2 11.9 1.1 2.1 2 1 1 3 3 3 0 E7 protein, Early protein Peptidase_S49_N PF08496.10 ETO13192.1 - 8.1 6.5 10.9 0.45 10.6 0.6 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF3043 PF11241.8 ETO13193.1 - 0.018 15.1 1.2 0.018 15.1 1.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) FAM176 PF14851.6 ETO13193.1 - 1.3 8.6 9.5 6.9 6.3 7.2 2.4 2 0 0 2 2 2 0 FAM176 family Apis_Csd PF11671.8 ETO13193.1 - 1.5 8.8 18.8 3.5 7.6 4.1 2.5 2 0 0 2 2 2 0 Complementary sex determiner protein IBB PF01749.20 ETO13194.1 - 8.6e-06 26.1 2.9 2e-05 25.0 2.9 1.7 1 0 0 1 1 1 1 Importin beta binding domain DUF3385 PF11865.8 ETO13194.1 - 0.029 14.3 0.1 0.048 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3385) DUF4746 PF15928.5 ETO13194.1 - 0.031 13.7 1.8 0.036 13.5 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) WD40 PF00400.32 ETO13196.1 - 8.5e-12 45.4 0.0 2.4e-06 28.1 0.0 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13196.1 - 0.017 15.4 0.0 0.027 14.8 0.0 1.4 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain CHASE9 PF17153.4 ETO13197.1 - 0.061 13.5 0.0 0.082 13.1 0.0 1.2 1 0 0 1 1 1 0 Periplasmic sensor domain, extracellular Cas6 PF09559.10 ETO13197.1 - 0.082 12.9 0.0 0.086 12.8 0.0 1.2 1 0 0 1 1 1 0 Cas6 Crispr DUF16 PF01519.16 ETO13197.1 - 0.11 12.9 2.1 0.18 12.3 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF16 MID_MedPIWI PF18296.1 ETO13198.1 - 0.0071 16.2 15.1 0.0071 16.2 15.1 2.2 1 1 1 2 2 2 1 MID domain of medPIWI VPS13 PF16908.5 ETO13199.1 - 2.5e-16 60.2 4.1 5.2e-12 46.1 0.9 2.2 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal Utp14 PF04615.13 ETO13199.1 - 0.0089 14.7 7.9 0.011 14.4 7.9 1.1 1 0 0 1 1 1 1 Utp14 protein FYDLN_acid PF09538.10 ETO13199.1 - 0.0097 16.6 4.3 0.0097 16.6 4.3 2.1 3 0 0 3 3 3 1 Protein of unknown function (FYDLN_acid) Ketoacyl-synt_2 PF13723.6 ETO13199.1 - 0.088 12.4 2.7 0.16 11.6 2.7 1.4 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain SID-1_RNA_chan PF13965.6 ETO13199.1 - 0.1 11.0 1.5 0.15 10.5 1.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NOA36 PF06524.12 ETO13199.1 - 0.12 11.7 5.0 0.22 10.8 5.0 1.4 1 0 0 1 1 1 0 NOA36 protein DUF4834 PF16118.5 ETO13199.1 - 0.75 10.8 10.3 1.3 10.1 2.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) RPN2_C PF18004.1 ETO13199.1 - 1.3 8.9 9.4 0.093 12.6 4.1 1.7 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Eapp_C PF10238.9 ETO13199.1 - 1.8 8.7 11.0 0.034 14.2 3.5 2.0 2 1 0 2 2 2 0 E2F-associated phosphoprotein FAM60A PF15396.6 ETO13199.1 - 7 6.6 12.4 11 6.0 5.7 2.1 2 0 0 2 2 2 0 Protein Family FAM60A WD40 PF00400.32 ETO13200.1 - 3.4e-14 53.0 6.0 0.0018 19.1 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO13200.1 - 0.0025 17.8 0.1 0.022 14.8 0.0 2.3 2 0 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 ETO13200.1 - 0.022 15.0 0.0 0.4 11.0 0.0 2.6 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain BLUF PF04940.12 ETO13200.1 - 0.04 14.0 0.2 6.8 6.9 0.0 3.3 3 1 0 3 3 3 0 Sensors of blue-light using FAD DEAD PF00270.29 ETO13201.1 - 0.0016 18.2 0.0 0.007 16.2 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase PhoH PF02562.16 ETO13201.1 - 0.064 12.7 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein COBRA1 PF06209.13 ETO13202.1 - 4.8e-05 22.4 4.6 0.02 13.8 0.9 2.4 2 0 0 2 2 2 2 Cofactor of BRCA1 (COBRA1) Importin_rep_2 PF18786.1 ETO13202.1 - 1.3 9.0 7.0 0.87 9.5 0.5 3.6 4 0 0 4 4 4 0 Importin 13 repeat Myotub-related PF06602.14 ETO13203.1 - 9.3e-70 235.3 0.2 9.3e-70 235.3 0.2 1.6 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain DSPc PF00782.20 ETO13203.1 - 0.012 15.4 0.9 0.029 14.2 0.0 2.2 2 1 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO13203.1 - 0.048 13.6 0.0 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Tyrosine phosphatase family Peptidase_S49_N PF08496.10 ETO13204.1 - 6 6.9 15.8 10 6.2 0.8 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF370 PF04025.12 ETO13205.1 - 0.0033 17.5 0.0 0.071 13.2 0.1 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF370) MIT PF04212.18 ETO13205.1 - 0.52 10.4 5.2 1.9 8.6 0.3 3.0 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain NAD_Gly3P_dh_N PF01210.23 ETO13205.1 - 1.1 9.3 3.4 2.8 7.9 0.2 2.2 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus LtuA PF17446.2 ETO13206.1 - 0.036 14.5 0.1 0.061 13.7 0.1 1.3 1 0 0 1 1 1 0 Late transcription unit A SNF2_N PF00176.23 ETO13207.1 - 1e-12 47.5 0.1 1.2e-12 47.2 0.1 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain Aminotran_3 PF00202.21 ETO13209.1 - 1e-42 146.2 0.0 1.3e-42 145.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III SP_C-Propep PF08999.10 ETO13210.1 - 1.1 9.1 3.4 2.3 8.1 3.4 1.5 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide ASFV_J13L PF05568.11 ETO13210.1 - 8.6 6.1 7.5 16 5.2 7.5 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein WD40 PF00400.32 ETO13216.1 - 1.8e-39 133.0 35.3 1e-06 29.3 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13216.1 - 1.6e-13 50.7 0.9 0.04 14.2 0.0 5.8 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13216.1 - 1.9e-09 36.7 5.3 0.089 11.4 0.2 5.9 3 2 1 6 6 6 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO13216.1 - 5e-06 27.1 2.5 5e-06 27.1 2.5 2.5 2 0 0 2 2 2 1 TRAF-type zinc finger WD40 PF00400.32 ETO13217.1 - 5.7e-127 409.9 60.4 7.8e-09 36.0 0.0 14.6 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13217.1 - 1.9e-39 133.9 13.9 0.0038 17.5 0.0 13.9 1 1 13 14 14 14 13 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO13217.1 - 1.5e-27 96.8 7.0 1.3e-05 24.7 0.0 9.3 3 2 6 9 9 9 6 WD40-like domain Ge1_WD40 PF16529.5 ETO13217.1 - 1e-24 87.1 17.6 0.3 10.0 0.0 13.4 1 1 11 13 13 13 10 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO13217.1 - 1.1e-13 50.7 32.5 0.035 12.7 0.2 11.9 1 1 12 13 13 13 6 Nucleoporin Nup120/160 NACHT PF05729.12 ETO13217.1 - 3e-08 33.8 0.0 6.1e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 ETO13217.1 - 2e-07 29.9 7.5 0.04 12.5 0.1 4.7 3 1 1 5 5 5 3 Cytochrome D1 heme domain Rpn3_C PF08375.11 ETO13217.1 - 1.7e-05 25.1 0.1 43 4.6 0.0 7.2 8 0 0 8 8 5 0 Proteasome regulatory subunit C-terminal Pentapeptide PF00805.22 ETO13217.1 - 1.8e-05 24.3 2.9 0.0025 17.4 0.1 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Gmad1 PF10647.9 ETO13217.1 - 4.9e-05 23.2 4.5 2.4 7.8 0.9 5.5 3 2 1 4 4 4 2 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 ETO13217.1 - 0.00031 20.6 10.8 33 4.6 0.0 8.5 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO13217.1 - 0.00079 19.5 30.0 7.2 6.7 0.2 7.9 2 2 5 7 7 7 1 Family of unknown function (DUF5570) AAA_22 PF13401.6 ETO13217.1 - 0.0015 18.8 0.0 0.0045 17.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain Resistin PF06954.11 ETO13217.1 - 0.0055 17.2 11.5 2.1 9.0 0.3 5.1 4 0 0 4 4 4 1 Resistin Invas_SpaK PF03519.14 ETO13217.1 - 0.0069 16.4 9.0 0.34 11.0 0.1 4.9 5 0 0 5 5 4 1 Invasion protein B family AAA_18 PF13238.6 ETO13217.1 - 0.0091 16.5 0.0 0.038 14.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO13217.1 - 0.033 14.6 0.3 0.42 11.0 0.0 2.8 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO13217.1 - 0.061 13.8 0.3 0.45 11.0 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Pentapeptide_4 PF13599.6 ETO13217.1 - 0.1 12.8 0.7 1.8 8.8 0.2 3.0 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) WD40_3 PF15911.5 ETO13217.1 - 1.6 8.8 4.8 13 5.9 0.0 4.8 7 1 1 8 8 7 0 WD domain, G-beta repeat KMP11 PF03037.16 ETO13217.1 - 6.7 7.6 11.0 8.6 7.2 0.7 3.5 3 0 0 3 3 3 0 Kinetoplastid membrane protein 11 Nop14 PF04147.12 ETO13218.1 - 6.8 4.8 47.5 9.2 4.3 47.5 1.2 1 0 0 1 1 1 0 Nop14-like family PDZ_6 PF17820.1 ETO13219.1 - 1.3e-09 37.8 0.0 0.0012 18.6 0.0 2.2 2 0 0 2 2 2 2 PDZ domain PDZ PF00595.24 ETO13219.1 - 5.7e-09 36.2 0.3 0.00037 20.8 0.2 2.3 2 0 0 2 2 2 2 PDZ domain Laminin_G_3 PF13385.6 ETO13220.1 - 0.019 15.1 0.8 0.038 14.1 0.8 1.4 1 0 0 1 1 1 0 Concanavalin A-like lectin/glucanases superfamily Orf78 PF06024.12 ETO13220.1 - 5.1 7.4 8.3 0.56 10.5 0.7 2.5 2 0 0 2 2 2 0 Orf78 (ac78) Nop14 PF04147.12 ETO13221.1 - 0.0003 19.2 9.0 0.00033 19.1 9.0 1.2 1 0 0 1 1 1 1 Nop14-like family DUF2052 PF09747.9 ETO13221.1 - 0.00049 20.3 10.2 0.0007 19.8 10.2 1.3 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Erythro_esteras PF05139.14 ETO13221.1 - 0.0012 18.8 3.5 0.0016 18.4 3.5 1.2 1 0 0 1 1 1 1 Erythromycin esterase CDC45 PF02724.14 ETO13221.1 - 0.006 14.9 7.8 0.0073 14.7 7.8 1.2 1 0 0 1 1 1 1 CDC45-like protein CobT PF06213.12 ETO13221.1 - 0.0088 15.5 9.0 0.011 15.1 9.0 1.1 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT DDHD PF02862.17 ETO13221.1 - 0.0091 16.2 3.2 0.012 15.8 3.2 1.2 1 0 0 1 1 1 1 DDHD domain DUF4898 PF16239.5 ETO13221.1 - 0.021 14.7 0.6 0.48 10.4 0.0 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4898) Cnd2 PF05786.14 ETO13221.1 - 0.039 12.6 8.5 0.064 11.9 8.5 1.3 1 0 0 1 1 1 0 Condensin complex subunit 2 BUD22 PF09073.10 ETO13221.1 - 0.066 12.5 11.6 0.086 12.2 11.6 1.2 1 0 0 1 1 1 0 BUD22 TFIIF_alpha PF05793.12 ETO13221.1 - 0.077 11.6 15.9 0.095 11.3 15.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sporozoite_P67 PF05642.11 ETO13221.1 - 0.093 10.8 4.1 0.11 10.6 4.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ETO13221.1 - 0.37 10.1 11.4 0.53 9.6 11.4 1.2 1 0 0 1 1 1 0 NOA36 protein RPN2_C PF18004.1 ETO13221.1 - 0.59 10.0 13.9 1 9.2 13.9 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Usp PF00582.26 ETO13221.1 - 1.3 9.5 3.8 2.2 8.8 3.8 1.3 1 0 0 1 1 1 0 Universal stress protein family PTPRCAP PF15713.5 ETO13221.1 - 1.4 9.2 14.3 2.1 8.6 14.3 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RNA_pol_3_Rpc31 PF11705.8 ETO13221.1 - 1.5 9.0 18.6 2.2 8.5 18.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 SURF2 PF05477.11 ETO13221.1 - 1.5 8.4 14.8 2.1 8.0 14.8 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF4637 PF15470.6 ETO13221.1 - 1.6 8.4 18.2 3.2 7.5 17.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Mem_trans PF03547.18 ETO13221.1 - 1.8 6.9 3.8 2.6 6.4 3.8 1.2 1 0 0 1 1 1 0 Membrane transport protein CENP-B_dimeris PF09026.10 ETO13221.1 - 2 8.9 13.2 4.3 7.8 13.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4820 PF16091.5 ETO13221.1 - 2.6 7.4 7.1 3.8 6.8 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2457 PF10446.9 ETO13221.1 - 2.9 7.0 18.4 3.9 6.5 18.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nucleoside_tran PF01733.18 ETO13221.1 - 3.4 7.0 5.2 6.5 6.0 5.2 1.4 1 0 0 1 1 1 0 Nucleoside transporter Zip PF02535.22 ETO13221.1 - 3.5 6.8 5.0 4.3 6.5 5.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO13221.1 - 8.1 5.1 8.3 11 4.7 8.3 1.2 1 0 0 1 1 1 0 Presenilin Pox_Ag35 PF03286.14 ETO13221.1 - 9.8 5.9 15.1 18 5.0 15.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Aa_trans PF01490.18 ETO13222.1 - 2.1e-36 125.5 22.1 7e-36 123.8 22.1 1.8 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ETO13222.1 - 0.33 9.9 13.6 0.056 12.5 9.0 1.9 2 1 0 2 2 2 0 Tryptophan/tyrosine permease family DUF2830 PF11125.8 ETO13222.1 - 2.3 8.3 5.4 5.3 7.1 0.4 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2830) Aa_trans PF01490.18 ETO13223.1 - 1.3e-08 34.0 5.1 1.3e-08 34.0 5.1 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein DUF2556 PF10831.8 ETO13223.1 - 0.029 14.3 0.1 0.065 13.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2556) SPC12 PF06645.13 ETO13223.1 - 0.12 12.5 2.8 0.21 11.7 2.8 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) CAP_GLY PF01302.25 ETO13224.1 - 1.6e-09 37.6 0.3 3.3e-09 36.6 0.3 1.5 1 0 0 1 1 1 1 CAP-Gly domain CDC45 PF02724.14 ETO13224.1 - 0.42 8.9 20.6 0.63 8.3 20.6 1.3 1 0 0 1 1 1 0 CDC45-like protein FANCI_S4 PF14678.6 ETO13225.1 - 0.00089 18.4 1.4 0.00092 18.4 1.4 1.1 1 0 0 1 1 1 1 FANCI solenoid 4 Baculo_PEP_C PF04513.12 ETO13225.1 - 0.0029 17.6 0.2 0.0037 17.3 0.2 1.3 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus zf-3CxxC PF13695.6 ETO13225.1 - 0.044 14.2 1.2 0.058 13.9 1.2 1.3 1 0 0 1 1 1 0 Zinc-binding domain Fe-S_assembly PF04384.13 ETO13225.1 - 0.1 13.2 0.0 0.23 12.1 0.0 1.6 1 0 0 1 1 1 0 Iron-sulphur cluster assembly DctP PF03480.13 ETO13225.1 - 0.11 11.8 0.2 0.14 11.4 0.2 1.1 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein, family 7 Nudix_hydro PF18290.1 ETO13226.1 - 0.0042 17.0 0.6 0.56 10.2 0.3 2.3 2 0 0 2 2 2 2 Nudix hydrolase domain Med2 PF11214.8 ETO13227.1 - 0.015 15.4 1.4 0.015 15.4 1.4 3.0 1 1 2 3 3 3 0 Mediator complex subunit 2 DUF386 PF04074.12 ETO13227.1 - 0.027 14.4 1.6 0.027 14.4 1.6 1.9 2 0 0 2 2 2 0 YhcH/YjgK/YiaL TolA_bind_tri PF16331.5 ETO13227.1 - 0.067 13.3 0.5 0.067 13.3 0.5 3.4 3 0 0 3 3 3 0 TolA binding protein trimerisation Fib_alpha PF08702.10 ETO13227.1 - 0.42 10.8 14.1 0.31 11.2 11.7 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family NPV_P10 PF05531.12 ETO13227.1 - 0.67 10.5 6.5 1.9 9.0 2.6 2.9 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Lectin_N PF03954.14 ETO13227.1 - 1 9.1 11.6 0.09 12.5 5.3 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF4407 PF14362.6 ETO13227.1 - 1.4 8.2 12.9 1.8 7.8 12.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tropomyosin_1 PF12718.7 ETO13227.1 - 2.6 8.2 29.9 0.56 10.4 6.8 2.5 1 1 1 2 2 2 0 Tropomyosin like MPS2 PF17060.5 ETO13227.1 - 2.8 7.1 20.3 1.2 8.3 11.1 2.0 1 1 1 2 2 2 0 Monopolar spindle protein 2 Sec2p PF06428.11 ETO13227.1 - 4.1 7.4 31.4 0.21 11.6 2.5 3.3 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Syntaxin-6_N PF09177.11 ETO13227.1 - 7.2 7.2 13.7 0.81 10.3 2.5 2.3 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Evr1_Alr PF04777.13 ETO13228.1 - 1.9e-26 92.4 0.3 1.9e-26 92.4 0.3 1.7 2 0 0 2 2 2 1 Erv1 / Alr family STE3 PF02076.15 ETO13229.1 - 0.012 14.9 0.1 0.018 14.2 0.1 1.2 1 0 0 1 1 1 0 Pheromone A receptor PhdYeFM_antitox PF02604.19 ETO13229.1 - 0.045 13.6 2.7 0.23 11.3 1.9 2.2 2 0 0 2 2 2 0 Antitoxin Phd_YefM, type II toxin-antitoxin system Spt20 PF12090.8 ETO13230.1 - 0.00065 19.4 15.9 0.0016 18.1 15.9 1.6 1 0 0 1 1 1 1 Spt20 family ETRAMP PF09716.10 ETO13230.1 - 0.01 15.9 3.8 0.05 13.7 3.8 2.2 1 0 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF4407 PF14362.6 ETO13230.1 - 0.068 12.5 1.5 0.12 11.7 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zip PF02535.22 ETO13230.1 - 2.7 7.1 17.8 2.7 7.1 6.3 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Macoilin PF09726.9 ETO13230.1 - 3.1 6.2 23.7 0.91 8.0 6.0 2.2 2 0 0 2 2 2 0 Macoilin family HCO3_cotransp PF00955.21 ETO13230.1 - 9.4 4.9 13.7 0.22 10.3 4.6 2.1 2 0 0 2 2 2 0 HCO3- transporter family IHABP4_N PF16174.5 ETO13231.1 - 0.19 12.3 13.6 0.23 12.1 13.6 1.0 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal MAJIN PF15077.6 ETO13231.1 - 4.6 7.0 9.9 5.7 6.7 9.9 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein Pex16 PF08610.10 ETO13232.1 - 5e-24 85.1 0.0 6.4e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Nucleolin_bd PF16725.5 ETO13232.1 - 0.031 13.9 0.0 0.055 13.1 0.0 1.4 1 0 0 1 1 1 0 Nucleolin binding domain Hormone_1 PF00103.20 ETO13232.1 - 0.077 12.7 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 Somatotropin hormone family Pkinase PF00069.25 ETO13233.1 - 0.00048 19.6 0.0 0.00048 19.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain CAC1F_C PF16885.5 ETO13233.1 - 0.011 15.4 6.6 0.012 15.3 6.6 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term PglD_N PF17836.1 ETO13233.1 - 0.034 14.8 0.7 0.064 13.9 0.1 1.7 2 0 0 2 2 2 0 PglD N-terminal domain SMYLE_N PF18615.1 ETO13233.1 - 0.065 12.8 5.1 0.075 12.6 5.1 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain LAP1C PF05609.12 ETO13233.1 - 0.12 11.5 9.1 0.13 11.3 9.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) FHIPEP PF00771.20 ETO13233.1 - 0.25 9.8 1.0 0.24 9.8 1.0 1.2 1 0 0 1 1 1 0 FHIPEP family Presenilin PF01080.17 ETO13233.1 - 0.43 9.3 8.6 0.5 9.1 8.6 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 ETO13233.1 - 0.43 9.0 8.1 0.47 8.9 8.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 CDC45 PF02724.14 ETO13233.1 - 0.49 8.6 11.5 0.57 8.4 11.5 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETO13233.1 - 0.6 9.8 9.2 1 9.0 9.2 1.4 1 0 0 1 1 1 0 FAM176 family DUF4637 PF15470.6 ETO13233.1 - 0.75 9.5 12.1 0.94 9.2 12.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PI3K_1B_p101 PF10486.9 ETO13233.1 - 1.3 6.8 7.2 1.4 6.6 7.2 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Zip PF02535.22 ETO13233.1 - 1.3 8.1 3.2 1.5 8.0 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 ETO13233.1 - 1.4 8.4 8.7 1.6 8.2 8.7 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 CobT PF06213.12 ETO13233.1 - 1.6 8.1 12.8 2 7.8 12.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3899 PF13038.6 ETO13233.1 - 1.9 9.1 3.1 3.3 8.3 3.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) Ndc1_Nup PF09531.10 ETO13233.1 - 4 6.0 4.4 4.2 5.9 4.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mem_trans PF03547.18 ETO13233.1 - 4 5.7 6.1 5.3 5.3 6.1 1.1 1 0 0 1 1 1 0 Membrane transport protein CLN3 PF02487.17 ETO13233.1 - 5.8 5.9 7.2 8.4 5.3 7.2 1.2 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 ETO13233.1 - 7.5 6.2 8.3 11 5.7 8.3 1.2 1 0 0 1 1 1 0 Connexin MCM_bind PF09739.9 ETO13233.1 - 8.6 4.7 10.9 11 4.3 10.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor AAA PF00004.29 ETO13234.1 - 1.2e-11 45.1 0.0 1.6e-10 41.5 0.0 2.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ETO13234.1 - 0.00033 20.3 0.0 0.00083 19.0 0.0 1.6 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO13234.1 - 0.00046 20.6 0.0 0.00095 19.6 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 ETO13234.1 - 0.012 15.5 0.0 0.063 13.2 0.0 2.0 1 1 1 2 2 2 0 NACHT domain ATPase PF06745.13 ETO13234.1 - 0.018 14.4 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 KaiC Viral_helicase1 PF01443.18 ETO13234.1 - 0.031 14.0 0.0 0.06 13.1 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_22 PF13401.6 ETO13234.1 - 0.043 14.1 0.0 0.18 12.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain BCS1_N PF08740.11 ETO13234.1 - 0.048 13.6 0.0 3.6 7.5 0.0 2.3 2 0 0 2 2 2 0 BCS1 N terminal AAA_29 PF13555.6 ETO13234.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 ETO13234.1 - 0.054 14.1 0.0 0.17 12.4 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETO13234.1 - 0.069 12.7 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ETO13234.1 - 0.082 13.3 0.0 0.61 10.5 0.0 2.2 2 0 0 2 2 2 0 RNA helicase AAA_23 PF13476.6 ETO13234.1 - 0.11 12.9 0.0 0.28 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO13234.1 - 0.14 12.1 0.0 0.25 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Peptidase_C48 PF02902.19 ETO13235.1 - 3.9e-26 92.2 10.0 6.3e-26 91.6 10.0 1.3 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C5 PF00770.18 ETO13235.1 - 0.2 11.3 4.5 0.28 10.8 0.5 2.3 1 1 1 2 2 2 0 Adenovirus endoprotease RGS PF00615.19 ETO13236.1 - 9.1e-12 45.3 1.3 1.7e-11 44.5 0.0 2.2 2 1 1 3 3 3 1 Regulator of G protein signaling domain RskA PF10099.9 ETO13236.1 - 0.007 16.7 6.4 0.015 15.6 6.4 1.5 1 0 0 1 1 1 1 Anti-sigma-K factor rskA ADH_zinc_N_2 PF13602.6 ETO13238.1 - 1.8e-13 51.7 0.0 3.9e-13 50.6 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ETO13238.1 - 1.1e-10 41.6 0.0 3e-10 40.2 0.0 1.7 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO13238.1 - 1.5e-09 37.7 0.1 9.5e-08 31.9 0.0 3.1 2 2 1 3 3 3 1 Alcohol dehydrogenase GroES-like domain WD40 PF00400.32 ETO13239.1 - 5.5e-20 71.3 18.5 7.2e-06 26.6 1.2 6.3 4 2 1 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13239.1 - 9.4e-08 32.3 2.0 0.1 12.9 0.1 4.2 3 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13239.1 - 1.2e-05 24.1 1.4 0.023 13.3 0.3 3.2 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Exostosin PF03016.15 ETO13240.1 - 3.4e-26 92.1 0.0 4.7e-26 91.7 0.0 1.1 1 0 0 1 1 1 1 Exostosin family SEA PF01390.20 ETO13240.1 - 0.09 12.9 0.0 0.15 12.2 0.0 1.3 1 0 0 1 1 1 0 SEA domain zf-CRD PF17979.1 ETO13241.1 - 0.0018 18.4 0.7 0.0033 17.5 0.1 1.6 2 0 0 2 2 2 1 Cysteine rich domain with multizinc binding regions NTF-like PF14540.6 ETO13243.1 - 0.0093 15.7 0.6 0.023 14.5 0.1 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase-like PDEase_I_N PF08499.12 ETO13243.1 - 0.16 11.8 0.8 0.35 10.7 0.8 1.6 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase N-terminal PTPlike_phytase PF14566.6 ETO13244.1 - 9.6e-24 84.3 0.0 3e-23 82.7 0.0 1.8 1 0 0 1 1 1 1 Inositol hexakisphosphate Neur_chan_memb PF02932.16 ETO13244.1 - 1.6e-05 25.1 0.6 0.00012 22.3 0.2 2.2 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region DSPc PF00782.20 ETO13244.1 - 0.022 14.6 0.0 0.076 12.8 0.0 2.0 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO13244.1 - 0.06 13.3 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF1948 PF09185.10 ETO13244.1 - 0.061 13.2 0.3 0.15 11.9 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1948) S-methyl_trans PF02574.16 ETO13244.1 - 0.086 12.6 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Homocysteine S-methyltransferase DUF2721 PF11026.8 ETO13244.1 - 0.89 9.5 0.0 0.89 9.5 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Band_3_cyto PF07565.13 ETO13247.1 - 0.019 14.8 8.5 0.059 13.2 1.6 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM110_C PF14160.6 ETO13247.1 - 0.18 12.9 7.7 22 6.2 0.0 3.7 3 0 0 3 3 3 0 Centrosome-associated C terminus MAS20 PF02064.15 ETO13247.1 - 0.26 11.4 0.1 0.26 11.4 0.1 3.1 3 0 0 3 3 3 0 MAS20 protein import receptor TRAP_alpha PF03896.16 ETO13247.1 - 0.49 9.6 9.1 1.3 8.1 2.8 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Nrap PF03813.14 ETO13247.1 - 0.81 9.7 4.0 0.16 12.0 0.3 1.8 2 0 0 2 2 2 0 Nrap protein domain 1 TFB6 PF17110.5 ETO13247.1 - 1.8 8.3 8.3 3.8 7.2 2.0 2.6 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH V_ATPase_I PF01496.19 ETO13247.1 - 5.4 4.8 8.2 2.7 5.8 1.4 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF3391 PF11871.8 ETO13247.1 - 8.5 6.9 10.4 12 6.4 2.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) Ins134_P3_kin_N PF17927.1 ETO13248.1 - 0.016 15.6 0.1 0.02 15.3 0.1 1.3 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain FRP PF18032.1 ETO13248.1 - 0.12 13.0 0.4 0.16 12.6 0.4 1.2 1 0 0 1 1 1 0 Photoprotection regulator fluorescence recovery protein VPS13 PF16908.5 ETO13249.1 - 5.8e-05 23.0 3.8 5.8e-05 23.0 3.8 2.4 2 1 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal DUF4718 PF15842.5 ETO13249.1 - 0.0035 17.2 0.1 0.0058 16.5 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4718) DUF1811 PF08838.10 ETO13249.1 - 0.047 13.9 2.0 0.14 12.4 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1811) ANAPC_CDC26 PF10471.9 ETO13250.1 - 0.0037 18.0 3.4 0.0037 18.0 3.4 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex APC subunit CDC26 SUIM_assoc PF16619.5 ETO13250.1 - 0.0057 16.7 2.7 0.016 15.2 2.7 1.8 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DICT PF10069.9 ETO13250.1 - 0.013 15.3 0.5 0.035 13.9 0.5 1.7 1 0 0 1 1 1 0 Sensory domain in DIguanylate Cyclases and Two-component system Apolipoprotein PF01442.18 ETO13251.1 - 0.017 15.0 0.6 0.034 14.0 0.6 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF3246 PF11596.8 ETO13251.1 - 0.024 14.1 3.3 0.035 13.5 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) NDT80_PhoG PF05224.12 ETO13251.1 - 0.92 9.7 9.2 1.4 9.1 9.2 1.4 1 1 0 1 1 1 0 NDT80 / PhoG like DNA-binding family Anticodon_1 PF08264.13 ETO13252.1 - 0.025 14.5 1.5 0.049 13.6 1.5 1.5 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA DUF4909 PF16253.5 ETO13252.1 - 0.14 12.0 1.1 0.37 10.6 0.2 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4909) FA_desaturase PF00487.24 ETO13252.1 - 1.5 8.6 6.6 0.79 9.5 3.7 1.9 2 0 0 2 2 2 0 Fatty acid desaturase DUF4231 PF14015.6 ETO13252.1 - 7.7 7.0 8.8 5.3 7.6 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) DUF773 PF05600.12 ETO13253.1 - 0.0053 15.6 7.8 0.0068 15.2 7.8 1.1 1 0 0 1 1 1 1 CDK5 regulatory subunit-associated protein 3 CPSase_L_D3 PF02787.19 ETO13253.1 - 0.0081 16.5 0.5 0.026 14.9 0.1 1.9 1 1 1 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain AAA_13 PF13166.6 ETO13253.1 - 0.034 12.8 12.2 0.043 12.5 12.2 1.1 1 0 0 1 1 1 0 AAA domain SesA PF17107.5 ETO13253.1 - 0.1 12.8 7.4 0.5 10.6 3.1 2.9 2 1 1 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Suppressor_APC PF11414.8 ETO13253.1 - 0.11 12.6 4.1 4.2 7.5 0.0 3.4 3 1 1 4 4 4 0 Adenomatous polyposis coli tumour suppressor protein AAA_19 PF13245.6 ETO13253.1 - 0.13 12.5 0.3 0.2 12.0 0.3 1.7 1 1 0 1 1 1 0 AAA domain V_ATPase_I PF01496.19 ETO13253.1 - 0.15 10.0 8.2 0.16 9.9 8.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ApoLp-III PF07464.11 ETO13253.1 - 0.26 11.4 9.7 0.31 11.1 3.3 2.6 2 1 1 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.11 ETO13253.1 - 0.47 10.7 5.2 2.7 8.3 3.6 2.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_MLP1_2 PF07926.12 ETO13253.1 - 0.48 10.5 9.7 0.054 13.6 4.6 1.9 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Phage_Mu_Gam PF07352.12 ETO13253.1 - 0.55 10.1 10.7 7.7 6.4 8.0 2.4 1 1 1 2 2 2 0 Bacteriophage Mu Gam like protein DUF1451 PF07295.11 ETO13253.1 - 0.7 9.9 5.8 3.6 7.6 2.3 2.7 2 1 1 3 3 3 0 Zinc-ribbon containing domain V-ATPase_G PF03179.15 ETO13253.1 - 1.1 9.9 7.8 4.1 8.0 7.9 2.0 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Laminin_II PF06009.12 ETO13253.1 - 1.8 8.6 7.3 1.1 9.3 5.1 1.8 1 1 1 2 2 2 0 Laminin Domain II Muted PF14942.6 ETO13253.1 - 2 8.7 13.6 0.43 10.9 9.1 2.0 1 1 1 2 2 2 0 Organelle biogenesis, Muted-like protein DUF4168 PF13767.6 ETO13253.1 - 3.2 9.0 7.8 52 5.1 4.8 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4168) Syntaxin_2 PF14523.6 ETO13253.1 - 4.6 7.7 10.1 1.1e+02 3.3 9.2 2.6 1 1 0 1 1 1 0 Syntaxin-like protein DUF4047 PF13256.6 ETO13253.1 - 5.4 7.2 10.3 2.6 8.2 7.7 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4047) DUF3450 PF11932.8 ETO13253.1 - 6.9 5.9 8.7 2.6 7.3 1.0 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DnaJ_C PF01556.18 ETO13254.1 - 3.3e-09 37.0 0.1 8.1e-09 35.7 0.0 1.6 2 0 0 2 2 2 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO13255.1 - 0.0011 19.3 4.2 0.33 11.3 0.8 2.5 2 0 0 2 2 2 2 DnaJ central domain Anti-TRAP PF15777.5 ETO13255.1 - 0.17 11.9 7.5 2.6 8.1 1.1 2.5 2 1 0 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein YhfH PF14149.6 ETO13259.1 - 0.075 13.0 0.5 0.2 11.7 0.5 1.6 1 0 0 1 1 1 0 YhfH-like protein MIF PF01187.18 ETO13259.1 - 0.13 12.6 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) DUF3449 PF11931.8 ETO13260.1 - 0.026 14.3 0.4 0.045 13.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3449) Sigma70_ner PF04546.13 ETO13261.1 - 0.0022 17.9 3.0 0.0025 17.7 3.0 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region SDA1 PF05285.12 ETO13261.1 - 0.0028 17.1 2.1 0.0028 17.1 2.1 1.0 1 0 0 1 1 1 1 SDA1 Cytomega_UL84 PF06284.11 ETO13261.1 - 0.0029 16.2 1.3 0.0032 16.0 1.3 1.1 1 0 0 1 1 1 1 Cytomegalovirus UL84 protein BSP_II PF05432.11 ETO13261.1 - 0.0093 15.7 9.5 0.012 15.3 9.5 1.0 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Mak16 PF04874.14 ETO13261.1 - 0.0098 16.5 8.2 0.013 16.1 8.2 1.1 1 0 0 1 1 1 1 Mak16 protein C-terminal region FAM176 PF14851.6 ETO13261.1 - 0.017 14.8 1.1 0.021 14.5 1.1 1.2 1 0 0 1 1 1 0 FAM176 family TRAP_alpha PF03896.16 ETO13261.1 - 0.06 12.5 2.7 0.076 12.2 2.7 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RRN3 PF05327.11 ETO13261.1 - 0.096 11.2 4.7 0.11 11.0 4.7 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Med8 PF10232.9 ETO13261.1 - 0.096 12.3 0.8 0.12 12.0 0.8 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Pox_Ag35 PF03286.14 ETO13261.1 - 0.2 11.4 5.0 0.24 11.1 5.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4637 PF15470.6 ETO13261.1 - 0.31 10.8 8.0 0.38 10.5 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PTPRCAP PF15713.5 ETO13261.1 - 0.39 11.0 8.2 0.48 10.7 8.2 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CENP-B_dimeris PF09026.10 ETO13261.1 - 0.44 11.0 18.5 0.68 10.4 18.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4611 PF15387.6 ETO13261.1 - 0.53 10.5 12.5 0.79 10.0 12.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RXT2_N PF08595.11 ETO13261.1 - 1.2 9.2 7.0 1.5 8.9 7.0 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal GOLD_2 PF13897.6 ETO13261.1 - 1.5 9.3 5.5 2.2 8.8 5.5 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking CDC45 PF02724.14 ETO13261.1 - 2.4 6.4 7.2 2.8 6.1 7.2 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 ETO13261.1 - 2.8 7.0 16.9 3.3 6.8 16.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MPP6 PF10175.9 ETO13261.1 - 3.5 8.2 6.7 4.6 7.7 6.7 1.1 1 0 0 1 1 1 0 M-phase phosphoprotein 6 PBP1_TM PF14812.6 ETO13261.1 - 9.9 6.6 12.9 20 5.6 12.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NnrU PF07298.11 ETO13262.1 - 0.017 14.6 0.1 0.022 14.2 0.1 1.1 1 0 0 1 1 1 0 NnrU protein UBA PF00627.31 ETO13263.1 - 6.7e-07 29.1 0.0 1.2e-06 28.3 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Phosphodiest PF01663.22 ETO13264.1 - 1.4e-33 117.0 0.2 1.8e-33 116.6 0.2 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ETO13264.1 - 0.0026 17.2 0.1 0.97 8.7 0.1 2.1 2 0 0 2 2 2 2 Metalloenzyme superfamily Sulfatase PF00884.23 ETO13264.1 - 0.021 14.2 0.1 0.023 14.1 0.1 1.2 1 0 0 1 1 1 0 Sulfatase DUF229 PF02995.17 ETO13264.1 - 0.19 10.3 0.1 0.21 10.1 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) fn3 PF00041.21 ETO13265.1 - 2.9e-08 33.9 0.8 8.5e-08 32.4 0.0 2.0 2 0 0 2 2 2 1 Fibronectin type III domain TFIIA PF03153.13 ETO13265.1 - 0.074 13.0 32.1 0.14 12.1 32.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit VWD PF00094.25 ETO13265.1 - 4.3 7.6 8.1 0.5 10.6 2.7 2.1 1 1 1 2 2 2 0 von Willebrand factor type D domain SH3_14 PF18343.1 ETO13267.1 - 0.021 14.9 0.2 0.05 13.7 0.2 1.6 1 0 0 1 1 1 0 Dda helicase SH3 domain Presenilin PF01080.17 ETO13267.1 - 0.078 11.7 12.2 0.13 11.0 12.2 1.3 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO13267.1 - 0.083 11.7 13.7 0.16 10.8 13.7 1.5 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 ETO13267.1 - 0.17 11.0 6.2 0.3 10.3 6.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter PNISR PF15996.5 ETO13267.1 - 7 6.9 10.2 20 5.4 10.2 1.7 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Paramyxo_ncap PF00973.19 ETO13267.1 - 9.1 5.1 8.9 37 3.1 0.0 2.2 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein Tudor-knot PF11717.8 ETO13268.1 - 0.4 10.6 4.2 0.38 10.7 1.8 2.2 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Laminin_G_3 PF13385.6 ETO13269.1 - 0.0069 16.5 0.0 0.017 15.3 0.0 1.6 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF2369 PF10179.9 ETO13269.1 - 0.0081 16.5 0.7 1.4 9.4 0.0 3.0 1 1 2 3 3 3 1 Uncharacterised conserved protein (DUF2369) EspG PF06872.11 ETO13271.1 - 0.051 12.1 0.1 0.063 11.8 0.1 1.1 1 0 0 1 1 1 0 EspG protein Barstar PF01337.18 ETO13272.1 - 0.038 14.0 0.0 0.11 12.5 0.0 1.8 1 0 0 1 1 1 0 Barstar (barnase inhibitor) DUF4834 PF16118.5 ETO13272.1 - 1.1 10.3 10.9 0.82 10.7 0.7 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) TLD PF07534.16 ETO13273.1 - 1.2e-15 58.0 0.0 1.4e-15 57.7 0.0 1.1 1 0 0 1 1 1 1 TLD BCAS2 PF05700.11 ETO13274.1 - 2.6e-46 157.9 18.3 2.6e-46 157.9 18.3 1.3 2 0 0 2 2 2 1 Breast carcinoma amplified sequence 2 (BCAS2) PMSR PF01625.21 ETO13274.1 - 0.34 11.1 4.1 9.7 6.3 1.4 2.5 2 1 0 2 2 2 0 Peptide methionine sulfoxide reductase LMBR1 PF04791.16 ETO13274.1 - 3.2 6.6 7.2 3.4 6.5 7.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FapA PF03961.13 ETO13274.1 - 4.1 5.9 7.8 5.2 5.6 7.8 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pkinase PF00069.25 ETO13275.1 - 6.9e-37 127.2 4.0 1.4e-25 90.1 0.1 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13275.1 - 2.3e-20 73.0 0.3 3e-13 49.7 0.2 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO13275.1 - 0.03 13.3 0.7 4.5 6.1 0.2 2.1 2 0 0 2 2 2 0 Haspin like kinase domain CBS PF00571.28 ETO13276.1 - 5.3e-16 58.8 0.0 0.00029 21.2 0.0 3.4 2 1 0 3 3 3 3 CBS domain GHMP_kinases_N PF00288.26 ETO13277.1 - 4.2e-05 23.7 0.2 8.5e-05 22.7 0.2 1.5 1 0 0 1 1 1 1 GHMP kinases N terminal domain RPN2_C PF18004.1 ETO13277.1 - 0.11 12.4 0.7 0.16 11.9 0.7 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SDA1 PF05285.12 ETO13277.1 - 0.48 9.8 10.5 0.65 9.4 10.5 1.1 1 0 0 1 1 1 0 SDA1 PBP1_TM PF14812.6 ETO13277.1 - 0.81 10.1 12.0 1.8 9.0 12.0 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pox_Ag35 PF03286.14 ETO13277.1 - 1.4 8.7 7.2 2.2 8.0 7.2 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO13277.1 - 3.1 5.8 7.9 4 5.4 7.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi FAM183 PF14886.6 ETO13278.1 - 3.4e-18 66.4 3.7 3.4e-18 66.4 3.7 1.6 2 0 0 2 2 2 1 FAM183A and FAM183B related PH PF00169.29 ETO13279.1 - 0.00016 22.1 0.8 0.00062 20.2 0.0 2.3 3 0 0 3 3 3 1 PH domain DUF5101 PF17031.5 ETO13279.1 - 0.00047 20.2 1.0 0.00047 20.2 1.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5101) ZapB PF06005.12 ETO13279.1 - 0.0032 17.9 5.6 0.013 15.9 5.6 2.1 1 0 0 1 1 1 1 Cell division protein ZapB FYVE PF01363.21 ETO13279.1 - 0.0044 17.1 0.5 0.01 16.0 0.5 1.6 1 0 0 1 1 1 1 FYVE zinc finger RhoGEF PF00621.20 ETO13279.1 - 0.015 15.5 0.3 0.046 14.0 0.3 1.8 1 0 0 1 1 1 0 RhoGEF domain UPF0242 PF06785.11 ETO13279.1 - 0.13 12.3 4.2 1.2 9.2 2.5 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus bZIP_2 PF07716.15 ETO13279.1 - 0.95 9.6 13.0 0.046 13.8 5.4 2.6 3 0 0 3 3 3 0 Basic region leucine zipper DMPK_coil PF08826.10 ETO13279.1 - 1.5 9.0 8.5 0.46 10.6 2.7 2.4 2 0 0 2 2 2 0 DMPK coiled coil domain like SNF2_N PF00176.23 ETO13280.1 - 1e-52 179.0 3.9 1.3e-50 172.1 3.9 2.7 1 1 1 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO13280.1 - 1.2e-16 61.0 1.0 1.1e-15 57.9 0.1 2.9 3 0 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO13280.1 - 0.0094 15.7 0.0 0.072 12.8 0.0 2.6 2 1 0 2 2 2 1 DEAD/DEAH box helicase zf-AD PF07776.15 ETO13281.1 - 0.018 15.3 0.9 0.077 13.2 0.6 2.3 1 1 0 1 1 1 0 Zinc-finger associated domain (zf-AD) Arm PF00514.23 ETO13281.1 - 0.043 13.9 0.0 0.11 12.6 0.0 1.7 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat RNA_pol_Rpb4 PF03874.16 ETO13281.1 - 2.2 8.6 7.1 0.75 10.1 1.6 2.6 3 0 0 3 3 3 0 RNA polymerase Rpb4 7TM_GPCR_Srbc PF10316.9 ETO13282.1 - 0.053 13.0 6.8 0.16 11.4 3.9 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srbc AAA_lid_6 PF17866.1 ETO13282.1 - 0.068 13.4 0.0 0.14 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA lid domain LRR19-TM PF15176.6 ETO13282.1 - 0.37 10.8 2.2 0.57 10.2 0.2 2.1 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain UvrD-helicase PF00580.21 ETO13283.1 - 4.2e-39 134.9 6.4 6.5e-39 134.3 6.4 1.2 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain UvrD_C PF13361.6 ETO13283.1 - 4.2e-19 69.1 0.3 4.2e-19 69.1 0.3 2.2 2 1 1 3 3 3 1 UvrD-like helicase C-terminal domain AAA_19 PF13245.6 ETO13283.1 - 6.1e-10 39.6 2.3 2.1e-09 37.9 2.3 1.9 1 1 0 1 1 1 1 AAA domain IF2_N PF04760.15 ETO13283.1 - 0.047 13.5 0.6 1.1 9.1 0.0 2.8 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region Seryl_tRNA_N PF02403.22 ETO13283.1 - 2.6 8.3 7.2 0.18 12.1 1.1 2.2 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain UvrD_C PF13361.6 ETO13284.1 - 3.1e-26 92.6 0.6 5.7e-26 91.7 0.6 1.4 1 1 0 1 1 1 1 UvrD-like helicase C-terminal domain UvrD_C_2 PF13538.6 ETO13284.1 - 1.3e-12 47.4 0.0 3.7e-05 23.4 0.0 2.4 2 0 0 2 2 2 2 UvrD-like helicase C-terminal domain Viral_helicase1 PF01443.18 ETO13284.1 - 0.064 13.0 0.1 14 5.3 0.0 2.4 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase DNA_pol_phi PF04931.13 ETO13285.1 - 0.48 8.5 20.1 0.93 7.5 20.1 1.4 1 0 0 1 1 1 0 DNA polymerase phi eIF-3c_N PF05470.12 ETO13285.1 - 0.59 8.4 25.3 0.1 10.9 19.9 2.0 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus zf-H2C2_2 PF13465.6 ETO13287.1 - 1.5e-09 37.8 2.9 2.3e-05 24.6 0.2 3.7 4 0 0 4 4 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETO13287.1 - 2.4e-08 34.0 17.7 0.0026 18.1 0.3 4.3 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ETO13287.1 - 2.7e-06 27.5 9.2 0.00017 21.7 1.7 4.0 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-C2H2_4 PF13894.6 ETO13287.1 - 3.6e-05 24.2 24.2 0.0092 16.7 3.5 4.6 5 0 0 5 5 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 ETO13287.1 - 0.00016 21.9 10.5 0.0043 17.3 2.4 2.7 1 1 2 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zinc_ribbon_9 PF14369.6 ETO13287.1 - 0.0042 17.3 4.6 0.028 14.7 0.1 3.4 4 0 0 4 4 4 1 zinc-ribbon C1_1 PF00130.22 ETO13287.1 - 0.0079 16.1 12.7 2.3 8.2 1.0 4.0 3 1 1 4 4 4 3 Phorbol esters/diacylglycerol binding domain (C1 domain) DZR PF12773.7 ETO13287.1 - 0.022 14.8 6.0 0.16 12.0 2.4 3.0 2 1 0 2 2 2 0 Double zinc ribbon PHD PF00628.29 ETO13287.1 - 0.03 14.2 5.0 0.28 11.1 2.0 2.5 2 0 0 2 2 2 0 PHD-finger ADK_lid PF05191.14 ETO13287.1 - 0.072 13.1 0.6 0.072 13.1 0.6 2.1 2 0 0 2 2 2 0 Adenylate kinase, active site lid HypA PF01155.19 ETO13287.1 - 0.081 12.9 2.6 0.67 10.0 2.5 2.1 1 1 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2HE PF16278.5 ETO13287.1 - 0.11 13.0 12.4 0.43 11.1 5.1 2.9 1 1 2 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf-met PF12874.7 ETO13287.1 - 0.14 12.6 8.7 2.3 8.7 1.8 3.4 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Zf_RING PF16744.5 ETO13287.1 - 0.2 11.8 5.7 1.1 9.5 2.0 2.7 1 1 1 2 2 2 0 KIAA1045 RING finger zf-C2H2_6 PF13912.6 ETO13287.1 - 0.29 11.2 13.5 2.7 8.1 0.1 3.8 3 1 0 3 3 3 0 C2H2-type zinc finger DUF2256 PF10013.9 ETO13287.1 - 1.1 9.4 12.6 3.3 7.9 0.6 4.6 5 0 0 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-C2H2_3rep PF18868.1 ETO13287.1 - 1.3 9.7 15.5 3.9 8.2 4.2 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats FYVE_2 PF02318.16 ETO13287.1 - 2.3 8.4 8.0 0.88 9.8 4.2 2.0 1 1 1 2 2 2 0 FYVE-type zinc finger FYVE PF01363.21 ETO13287.1 - 3.1 8.0 10.1 16 5.7 10.2 2.4 1 1 0 1 1 1 0 FYVE zinc finger His_Phos_1 PF00300.22 ETO13288.1 - 7.7e-09 35.5 0.0 1.3e-05 25.0 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) ASXH PF13919.6 ETO13288.1 - 0.1 12.6 0.3 0.18 11.8 0.3 1.3 1 0 0 1 1 1 0 Asx homology domain zf-Di19 PF05605.12 ETO13290.1 - 6.7e-07 29.5 1.0 6.7e-07 29.5 1.0 2.8 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ETO13290.1 - 3.3e-06 27.5 17.5 0.06 14.2 0.9 4.0 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_9 PF16293.5 ETO13290.1 - 0.21 11.4 6.9 1.2 9.1 0.0 3.6 3 1 1 4 4 4 0 C2H2 type zinc-finger (1 copy) DUF1178 PF06676.11 ETO13290.1 - 0.58 10.5 5.1 2.8 8.3 4.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1178) zf-H2C2_2 PF13465.6 ETO13290.1 - 0.91 10.1 13.8 3.1 8.4 0.1 4.8 5 0 0 5 5 5 0 Zinc-finger double domain Sgf11 PF08209.11 ETO13290.1 - 0.98 9.0 6.4 1.4 8.6 0.0 3.3 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-met PF12874.7 ETO13290.1 - 8.3 7.0 16.5 12 6.4 0.7 4.5 3 1 0 3 3 3 0 Zinc-finger of C2H2 type CAMSAP_CH PF11971.8 ETO13291.1 - 9e-07 28.6 0.1 4.1e-06 26.5 0.0 2.0 2 0 0 2 2 2 1 CAMSAP CH domain CH PF00307.31 ETO13291.1 - 2.2e-06 27.8 3.0 5.2e-06 26.6 0.4 2.3 2 0 0 2 2 2 1 Calponin homology (CH) domain CH_2 PF06294.11 ETO13291.1 - 0.003 17.7 0.1 0.0076 16.3 0.1 1.8 1 0 0 1 1 1 1 CH-like domain in sperm protein KELK PF15796.5 ETO13291.1 - 0.0037 17.7 4.1 0.026 15.0 4.1 2.2 1 1 0 1 1 1 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase UPF0242 PF06785.11 ETO13291.1 - 0.012 15.7 3.4 0.024 14.8 3.4 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus TMF_TATA_bd PF12325.8 ETO13291.1 - 0.014 15.6 0.5 0.038 14.2 0.5 1.7 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Cep57_CLD_2 PF14197.6 ETO13291.1 - 0.015 15.3 0.7 0.036 14.2 0.7 1.6 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 Arc_PepC PF06819.11 ETO13291.1 - 0.018 15.2 0.5 0.047 13.8 0.5 1.8 1 0 0 1 1 1 0 Archaeal Peptidase A24 C-terminal Domain EB1 PF03271.17 ETO13291.1 - 0.059 13.6 4.4 0.32 11.3 0.7 3.0 2 1 0 2 2 2 0 EB1-like C-terminal motif OrfB_IS605 PF01385.19 ETO13291.1 - 0.12 12.6 1.3 0.94 9.7 0.4 2.2 2 0 0 2 2 2 0 Probable transposase POX PF07526.11 ETO13293.1 - 0.2 12.3 10.7 0.32 11.5 0.2 2.4 3 0 0 3 3 3 0 Associated with HOX Menin PF05053.13 ETO13293.1 - 0.76 8.1 8.8 0.94 7.8 8.8 1.1 1 0 0 1 1 1 0 Menin ADK PF00406.22 ETO13294.1 - 8.6e-37 126.6 0.0 1.9e-36 125.4 0.0 1.6 2 0 0 2 2 2 1 Adenylate kinase AAA_17 PF13207.6 ETO13294.1 - 9.2e-15 55.3 0.0 2.7e-14 53.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ETO13294.1 - 4.3e-10 39.4 2.0 1e-09 38.2 2.0 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ETO13294.1 - 0.00027 21.5 0.0 0.00063 20.3 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO13294.1 - 0.0005 20.2 0.0 0.0013 18.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETO13294.1 - 0.023 14.4 0.0 0.039 13.7 0.0 1.3 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TerY_C PF15616.6 ETO13294.1 - 0.023 14.8 0.0 0.042 13.9 0.0 1.4 1 0 0 1 1 1 0 TerY-C metal binding domain Ribosomal_S19 PF00203.21 ETO13294.1 - 0.043 13.7 0.7 0.087 12.7 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein S19 TsaE PF02367.17 ETO13294.1 - 0.16 12.0 0.0 0.38 10.8 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE FeoB_associated PF12669.7 ETO13294.1 - 1.5 9.3 7.4 1.4 9.4 1.4 3.0 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Kelch_6 PF13964.6 ETO13295.1 - 2.8e-07 30.6 0.3 5e-06 26.6 0.1 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO13295.1 - 1.3e-05 24.6 0.2 5.5e-05 22.7 0.2 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO13295.1 - 0.00016 21.6 0.6 0.0027 17.7 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO13295.1 - 0.0016 18.7 0.1 0.018 15.4 0.0 2.6 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO13295.1 - 0.021 14.8 0.2 0.072 13.1 0.2 1.9 1 0 0 1 1 1 0 Kelch motif Rieske_2 PF13806.6 ETO13295.1 - 0.031 14.2 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 Rieske-like [2Fe-2S] domain Sulfate_transp PF00916.20 ETO13296.1 - 1.2e-18 67.1 6.8 1.8e-18 66.4 6.8 1.3 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ETO13296.1 - 0.001 18.7 0.0 0.0029 17.2 0.0 1.7 2 0 0 2 2 2 1 STAS domain Serpin PF00079.20 ETO13298.1 - 7e-05 22.3 0.1 8.3e-05 22.1 0.1 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) YIF1 PF03878.15 ETO13299.1 - 0.16 11.4 10.6 0.074 12.6 8.2 1.7 1 1 1 2 2 2 0 YIF1 DUF5480 PF17576.2 ETO13300.1 - 0.13 12.2 0.1 0.24 11.4 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5480) HORMA PF02301.18 ETO13301.1 - 1.1e-11 44.7 0.5 1.1e-11 44.7 0.5 1.0 1 0 0 1 1 1 1 HORMA domain HTH_45 PF14947.6 ETO13302.1 - 0.0084 16.1 0.0 0.018 15.0 0.0 1.5 1 0 0 1 1 1 1 Winged helix-turn-helix HTH_5 PF01022.20 ETO13302.1 - 0.021 14.7 0.0 0.049 13.5 0.0 1.7 1 0 0 1 1 1 0 Bacterial regulatory protein, arsR family HTH_24 PF13412.6 ETO13302.1 - 0.023 14.2 0.0 0.058 13.0 0.0 1.7 1 0 0 1 1 1 0 Winged helix-turn-helix DNA-binding ANAPC2 PF08672.11 ETO13302.1 - 0.025 15.1 0.0 0.059 13.9 0.0 1.6 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 HORMA PF02301.18 ETO13302.1 - 0.084 12.5 0.1 0.084 12.5 0.1 2.3 2 1 0 2 2 2 0 HORMA domain MarR_2 PF12802.7 ETO13302.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 MarR family DDRGK PF09756.9 ETO13302.1 - 0.24 11.0 8.7 1.1 8.9 8.3 1.9 1 1 0 1 1 1 0 DDRGK domain Dus PF01207.17 ETO13303.1 - 1.1e-37 129.8 0.1 1.3e-37 129.6 0.1 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) ACT PF01842.25 ETO13303.1 - 0.0079 16.0 0.0 4.5 7.1 0.0 2.6 2 0 0 2 2 2 2 ACT domain DHO_dh PF01180.21 ETO13303.1 - 0.025 13.8 0.0 0.028 13.6 0.0 1.1 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase PdxJ PF03740.13 ETO13303.1 - 0.059 12.5 0.1 0.14 11.2 0.1 1.7 1 1 0 1 1 1 0 Pyridoxal phosphate biosynthesis protein PdxJ PRAI PF00697.22 ETO13303.1 - 0.087 12.6 0.0 0.55 10.0 0.0 2.0 2 0 0 2 2 2 0 N-(5'phosphoribosyl)anthranilate (PRA) isomerase Fe-ADH PF00465.19 ETO13303.1 - 0.15 10.8 0.0 0.25 10.1 0.0 1.3 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase Phage_sheath_1C PF17482.2 ETO13304.1 - 0.023 14.6 0.1 0.1 12.6 0.0 2.1 2 1 1 3 3 3 0 Phage tail sheath C-terminal domain Glutaredoxin PF00462.24 ETO13304.1 - 0.03 14.5 0.0 0.13 12.5 0.0 2.1 2 0 0 2 2 2 0 Glutaredoxin UPF0242 PF06785.11 ETO13304.1 - 0.15 12.1 0.2 0.15 12.1 0.2 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus NAD_binding_6 PF08030.12 ETO13304.1 - 0.72 10.0 5.8 4.4 7.4 2.8 2.2 1 1 1 2 2 2 0 Ferric reductase NAD binding domain CorA PF01544.18 ETO13305.1 - 9.5e-34 117.0 0.3 1.5e-33 116.4 0.3 1.3 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein Rota_NS6 PF04866.12 ETO13305.1 - 0.73 10.1 3.1 0.56 10.5 0.3 2.2 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 CDC45 PF02724.14 ETO13307.1 - 0.82 7.9 11.8 0.83 7.9 11.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO13307.1 - 2 8.7 18.3 2.8 8.2 18.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Neur_chan_memb PF02932.16 ETO13307.1 - 3.2 7.8 11.3 3.9 7.5 11.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO13307.1 - 4.3 6.0 15.1 4.4 6.0 15.1 1.1 1 0 0 1 1 1 0 Presenilin Glyco_hydro_18 PF00704.28 ETO13308.1 - 4.7e-09 36.4 0.9 5.4e-09 36.2 0.9 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 7tm_7 PF08395.12 ETO13309.1 - 0.0021 17.4 0.1 0.0025 17.1 0.1 1.1 1 0 0 1 1 1 1 7tm Chemosensory receptor PRP1_N PF06424.12 ETO13309.1 - 0.0072 16.7 2.8 0.0091 16.4 2.8 1.2 1 0 0 1 1 1 1 PRP1 splicing factor, N-terminal Cytomega_UL84 PF06284.11 ETO13309.1 - 0.072 11.6 0.6 0.087 11.3 0.6 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PBP1_TM PF14812.6 ETO13309.1 - 0.47 10.8 6.8 0.73 10.2 6.8 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RRN3 PF05327.11 ETO13309.1 - 2 6.9 5.7 2.5 6.6 5.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CENP-B_dimeris PF09026.10 ETO13309.1 - 3.5 8.1 9.6 5.9 7.4 9.6 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ETO13309.1 - 3.8 6.6 10.4 4.8 6.2 10.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 ETO13309.1 - 4 6.7 11.0 0.65 9.3 7.5 1.4 2 0 0 2 2 2 0 NOA36 protein Exo_endo_phos PF03372.23 ETO13310.1 - 4.3e-08 33.0 0.1 7.1e-08 32.3 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CDC45 PF02724.14 ETO13311.1 - 0.11 10.8 6.1 0.13 10.5 6.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Afi1 PF07792.12 ETO13311.1 - 1.2 9.7 9.0 1.8 9.0 9.0 1.5 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 ETO13311.1 - 2.6 6.7 6.5 3.1 6.5 6.5 1.1 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ETO13312.1 - 0.0013 19.1 4.9 0.002 18.5 4.9 1.4 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 CDC45 PF02724.14 ETO13312.1 - 0.02 13.2 5.3 0.02 13.2 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein API5 PF05918.11 ETO13312.1 - 0.14 11.0 5.9 0.2 10.4 5.9 1.2 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) CobT PF06213.12 ETO13312.1 - 0.15 11.4 7.4 0.22 10.9 7.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 ETO13312.1 - 0.34 10.1 2.4 0.38 9.9 2.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO13312.1 - 0.43 9.3 2.8 0.52 9.0 2.8 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO13312.1 - 0.87 8.3 6.5 1 8.0 6.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TFB6 PF17110.5 ETO13312.1 - 1.6 8.5 6.1 36 4.0 6.4 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH FAM176 PF14851.6 ETO13312.1 - 2.9 7.6 6.1 5.6 6.6 6.1 1.5 1 0 0 1 1 1 0 FAM176 family V_ATPase_I PF01496.19 ETO13312.1 - 5.5 4.8 6.1 7.8 4.3 6.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family UN_NPL4 PF11543.8 ETO13313.1 - 0.00041 20.8 0.1 0.047 14.2 0.1 3.5 3 0 0 3 3 3 1 Nuclear pore localisation protein NPL4 Myc-LZ PF02344.15 ETO13313.1 - 0.0084 16.2 7.9 0.0084 16.2 7.9 2.2 2 0 0 2 2 2 1 Myc leucine zipper domain PB1 PF00564.24 ETO13313.1 - 0.073 13.0 0.2 14 5.7 0.0 3.0 2 0 0 2 2 2 0 PB1 domain SPAN-X PF07458.12 ETO13313.1 - 0.073 13.5 21.5 0.42 11.1 4.6 2.7 2 0 0 2 2 2 0 Sperm protein associated with nucleus, mapped to X chromosome ubiquitin PF00240.23 ETO13313.1 - 0.16 11.7 2.3 1.6 8.5 0.2 3.5 3 1 0 3 3 3 0 Ubiquitin family Roc PF08477.13 ETO13316.1 - 3e-19 69.4 0.0 3.2e-15 56.4 0.0 2.9 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO13316.1 - 3e-18 65.9 0.1 2e-15 56.7 0.0 2.4 2 1 0 2 2 2 2 Ras family GTP_EFTU PF00009.27 ETO13316.1 - 1.6e-06 27.8 0.3 0.0043 16.6 0.0 2.9 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain Arf PF00025.21 ETO13316.1 - 3.1e-06 26.7 0.3 0.019 14.4 0.0 2.8 1 1 2 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO13316.1 - 0.0002 20.8 0.2 0.0039 16.6 0.2 2.2 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO13316.1 - 0.00063 19.8 0.0 0.0023 18.0 0.0 1.9 2 0 0 2 2 2 1 50S ribosome-binding GTPase AAA_16 PF13191.6 ETO13316.1 - 0.0041 17.5 0.0 0.0079 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO13316.1 - 0.022 15.0 0.3 0.19 12.0 0.0 2.4 3 0 0 3 3 2 0 AAA domain AAA_18 PF13238.6 ETO13316.1 - 0.025 15.2 0.5 0.091 13.3 0.1 2.1 2 0 0 2 2 2 0 AAA domain RsgA_GTPase PF03193.16 ETO13316.1 - 0.051 13.5 0.2 1.7 8.5 0.0 2.4 2 1 0 2 2 2 0 RsgA GTPase AAA PF00004.29 ETO13316.1 - 0.096 13.1 0.0 0.32 11.4 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETO13316.1 - 0.14 12.0 0.0 0.34 10.8 0.0 1.7 1 1 0 1 1 1 0 NACHT domain Methyltransf_4 PF02390.17 ETO13318.1 - 7.3e-32 110.2 2.9 2.8e-31 108.3 2.8 1.7 1 1 1 2 2 2 1 Putative methyltransferase NO_synthase PF02898.15 ETO13318.1 - 0.053 12.6 0.1 0.066 12.2 0.1 1.1 1 0 0 1 1 1 0 Nitric oxide synthase, oxygenase domain FliJ PF02050.16 ETO13319.1 - 0.0077 16.4 8.0 0.0077 16.4 8.0 2.6 2 1 1 3 3 3 1 Flagellar FliJ protein Polyhedrin PF00738.18 ETO13319.1 - 0.02 14.2 0.5 0.027 13.8 0.5 1.2 1 0 0 1 1 1 0 Polyhedrin Pannexin_like PF12534.8 ETO13319.1 - 0.025 13.7 6.3 0.027 13.5 6.3 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Adhesin_P1_N PF18652.1 ETO13319.1 - 0.045 13.8 1.3 0.045 13.8 1.3 2.9 1 1 1 2 2 1 0 Adhesin P1 N-terminal domain Sec20 PF03908.13 ETO13319.1 - 0.057 13.3 1.9 0.12 12.4 1.1 1.9 1 1 0 1 1 1 0 Sec20 Nup54 PF13874.6 ETO13319.1 - 0.23 11.5 6.1 0.44 10.6 5.6 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF812 PF05667.11 ETO13319.1 - 0.3 9.9 20.2 0.39 9.6 20.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4407 PF14362.6 ETO13319.1 - 0.47 9.8 6.7 0.63 9.3 6.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KIP1 PF07765.12 ETO13319.1 - 1.4 9.1 8.3 0.68 10.1 5.2 2.1 1 1 1 2 2 2 0 KIP1-like protein Ndufs5 PF10200.9 ETO13319.1 - 1.6 9.0 6.0 0.97 9.7 3.4 2.1 2 1 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa FlaC_arch PF05377.11 ETO13319.1 - 2.4 8.6 9.0 21 5.6 7.3 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Syntaxin-18_N PF10496.9 ETO13319.1 - 3.2 8.1 8.4 1.7 8.9 5.5 2.2 1 1 1 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus FHIPEP PF00771.20 ETO13319.1 - 3.3 6.1 6.1 3.9 5.8 6.1 1.1 1 0 0 1 1 1 0 FHIPEP family Seryl_tRNA_N PF02403.22 ETO13319.1 - 8.3 6.7 18.9 9.8 6.5 11.2 2.5 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain WDCP PF15390.6 ETO13319.1 - 9.5 4.5 13.1 2.1 6.7 6.5 1.9 1 1 1 2 2 2 0 WD repeat and coiled-coil-containing protein family Ank_4 PF13637.6 ETO13320.1 - 0.02 15.5 0.0 22 5.8 0.0 3.5 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Ion_trans PF00520.31 ETO13320.1 - 0.032 13.4 0.9 2.3 7.4 0.1 2.3 2 0 0 2 2 2 0 Ion transport protein SieB PF14163.6 ETO13320.1 - 2 7.9 8.1 3.2 7.2 0.1 2.6 3 0 0 3 3 3 0 Super-infection exclusion protein B NID PF07292.13 ETO13321.1 - 0.026 15.2 0.7 0.038 14.6 0.7 1.2 1 0 0 1 1 1 0 Nmi/IFP 35 domain (NID) Herpes_teg_N PF04843.12 ETO13321.1 - 0.062 13.0 0.1 9.9 5.8 0.0 2.1 1 1 1 2 2 2 0 Herpesvirus tegument protein, N-terminal conserved region Cys_rich_KTR PF14205.6 ETO13321.1 - 0.085 12.7 0.0 0.21 11.4 0.0 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR EF-hand_1 PF00036.32 ETO13322.1 - 2.1e-28 95.7 21.9 1.7e-08 33.4 0.8 4.7 4 1 1 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETO13322.1 - 1.8e-24 86.0 14.9 2.2e-12 47.3 2.6 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO13322.1 - 7.1e-22 75.4 20.9 1.3e-07 31.0 0.9 5.1 3 1 3 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 ETO13322.1 - 3.1e-20 71.7 19.9 3.2e-13 49.3 1.7 3.9 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ETO13322.1 - 1.8e-17 61.9 21.9 2.1e-08 33.3 1.4 5.3 4 1 1 5 5 5 4 EF hand EF-hand_9 PF14658.6 ETO13322.1 - 1.7e-11 44.2 3.4 1.6e-05 25.1 0.1 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ETO13322.1 - 1.9e-07 31.0 9.6 0.00022 21.2 1.0 3.5 1 1 3 4 4 4 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO13322.1 - 3.7e-07 30.4 2.0 0.016 15.5 0.3 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 ETO13322.1 - 2.5e-06 27.5 1.5 0.059 13.3 0.0 3.1 2 1 1 3 3 3 2 Tellurite resistance protein TerB EF-hand_14 PF17959.1 ETO13322.1 - 0.0021 18.4 3.3 0.05 14.0 0.1 2.9 2 2 1 3 3 3 1 EF-hand domain Caleosin PF05042.13 ETO13322.1 - 0.0029 17.5 5.5 0.42 10.5 0.1 3.3 1 1 2 3 3 3 2 Caleosin related protein EF-hand_10 PF14788.6 ETO13322.1 - 0.011 15.6 3.0 0.06 13.2 0.2 2.5 2 0 0 2 2 2 0 EF hand DUF3349 PF11829.8 ETO13322.1 - 0.044 14.6 2.0 23 5.8 0.2 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF3349) DUF1456 PF07308.13 ETO13322.1 - 0.056 13.8 2.9 0.89 9.9 0.1 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1456) EF-hand_11 PF08976.11 ETO13322.1 - 0.11 13.3 0.6 18 6.3 0.0 2.5 1 1 1 2 2 2 0 EF-hand domain FRG1 PF06229.12 ETO13322.1 - 0.35 10.6 4.6 0.83 9.3 4.6 1.6 1 0 0 1 1 1 0 FRG1-like domain PRP9_N PF16958.5 ETO13322.1 - 0.65 10.0 9.4 1.2 9.2 6.1 2.2 1 1 1 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus TMEM214 PF10151.9 ETO13322.1 - 1.9 6.9 5.9 2.9 6.2 5.9 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator G-alpha PF00503.20 ETO13324.1 - 1.1e-15 57.7 1.3 1.3e-15 57.5 1.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit RFC1 PF08519.12 ETO13324.1 - 0.012 15.8 0.0 0.53 10.4 0.0 2.2 2 0 0 2 2 2 0 Replication factor RFC1 C terminal domain Anth_Ig PF05587.13 ETO13326.1 - 0.075 13.4 0.0 0.075 13.4 0.0 3.2 4 0 0 4 4 4 0 Anthrax receptor extracellular domain RCC1 PF00415.18 ETO13327.1 - 0.003 18.2 0.0 0.0087 16.7 0.0 1.9 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat ETRAMP PF09716.10 ETO13327.1 - 2.4 8.3 5.1 7.3 6.7 5.1 1.8 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2815 PF10991.8 ETO13328.1 - 0.051 13.5 0.6 0.059 13.3 0.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2815) RuvB_C PF05491.13 ETO13329.1 - 0.058 13.3 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 RuvB C-terminal winged helix domain WD40 PF00400.32 ETO13330.1 - 2.3e-09 37.7 5.3 0.022 15.6 0.0 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13330.1 - 0.051 13.9 0.2 22 5.5 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Nucleopor_Nup85 PF07575.13 ETO13332.1 - 8.5e-07 27.9 0.6 1.4e-06 27.2 0.6 1.3 1 0 0 1 1 1 1 Nup85 Nucleoporin PGM_PMM_II PF02879.16 ETO13332.1 - 0.083 13.5 0.0 6.6 7.4 0.0 2.4 1 1 1 2 2 2 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II 2HCT PF03390.15 ETO13332.1 - 0.17 10.5 0.0 0.19 10.3 0.0 1.1 1 0 0 1 1 1 0 2-hydroxycarboxylate transporter family E1-E2_ATPase PF00122.20 ETO13333.1 - 0.022 14.3 0.0 0.035 13.6 0.0 1.6 1 1 0 1 1 1 0 E1-E2 ATPase OEP PF02321.18 ETO13333.1 - 0.022 14.5 0.2 0.04 13.7 0.2 1.3 1 0 0 1 1 1 0 Outer membrane efflux protein Mlo PF03094.15 ETO13334.1 - 0.022 13.2 0.0 0.029 12.8 0.0 1.1 1 0 0 1 1 1 0 Mlo family HEAT PF02985.22 ETO13334.1 - 0.083 13.2 0.1 0.6 10.5 0.5 2.3 2 0 0 2 2 2 0 HEAT repeat HEAT_EZ PF13513.6 ETO13334.1 - 0.11 13.0 2.0 0.81 10.3 1.2 2.5 1 1 1 2 2 2 0 HEAT-like repeat HEAT PF02985.22 ETO13335.1 - 2.6e-05 24.1 0.1 0.13 12.6 0.0 3.2 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.7 ETO13335.1 - 0.00015 21.8 1.9 0.023 14.7 0.1 3.0 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 ETO13335.1 - 0.00045 19.5 0.0 0.0018 17.4 0.0 2.0 1 1 0 1 1 1 1 RNAPII transcription regulator C-terminal Vac14_Fab1_bd PF12755.7 ETO13335.1 - 0.0026 18.3 2.7 0.0055 17.3 0.2 2.7 2 1 0 3 3 3 1 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETO13335.1 - 0.0099 16.1 0.1 0.073 13.3 0.0 2.1 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Importin_rep_4 PF18808.1 ETO13335.1 - 0.016 15.5 0.2 0.25 11.7 0.0 2.5 2 1 1 3 3 3 0 Importin repeat HEAT_2 PF13646.6 ETO13335.1 - 0.029 14.7 0.0 0.93 9.9 0.0 2.9 2 1 1 3 3 3 0 HEAT repeats TIP120 PF08623.10 ETO13335.1 - 0.038 13.7 0.1 0.38 10.5 0.1 2.1 1 1 1 2 2 2 0 TATA-binding protein interacting (TIP20) MMS19_N PF14500.6 ETO13335.1 - 0.052 13.1 0.2 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II Ecm29 PF13001.7 ETO13335.1 - 0.063 12.0 0.1 0.25 10.0 0.0 1.9 2 0 0 2 2 2 0 Proteasome stabiliser HEAT PF02985.22 ETO13336.1 - 0.17 12.2 0.3 18 5.9 0.1 3.3 3 0 0 3 3 3 0 HEAT repeat CLIP_SPH_mas PF18398.1 ETO13336.1 - 0.37 11.2 0.2 0.37 11.2 0.2 2.5 2 0 0 2 2 2 0 Clip-domain serine protease homolog masquerade RGS PF00615.19 ETO13337.1 - 0.0015 18.8 2.5 0.0024 18.1 2.5 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain TPR_12 PF13424.6 ETO13339.1 - 1.6e-11 44.3 17.5 0.002 18.4 0.1 6.6 4 2 2 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13339.1 - 6.3e-09 35.4 17.9 0.032 14.4 0.2 7.4 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13339.1 - 3.6e-08 32.9 28.1 0.59 10.4 0.1 9.2 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13339.1 - 4.9e-08 32.5 30.5 0.05 13.4 0.4 8.7 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETO13339.1 - 1.6e-06 28.5 0.7 0.61 10.6 0.0 4.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO13339.1 - 3.5e-06 27.0 5.8 6.8 7.3 0.0 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO13339.1 - 1.7e-05 24.4 15.4 0.02 14.5 0.1 6.2 7 0 0 7 7 7 2 TPR repeat TPR_14 PF13428.6 ETO13339.1 - 0.00011 22.7 0.8 1.2 10.1 0.0 5.4 5 1 1 6 6 5 1 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 ETO13339.1 - 0.0011 19.4 0.6 0.0011 19.4 0.6 7.4 5 1 2 7 7 4 1 Centromere protein B dimerisation domain TPR_16 PF13432.6 ETO13339.1 - 0.0011 19.5 0.1 2.8 8.7 0.0 4.2 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO13339.1 - 0.0032 18.0 3.6 2.5 8.9 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO13339.1 - 0.036 14.1 12.5 0.055 13.5 1.5 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO13339.1 - 0.1 12.7 0.4 29 4.9 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO13339.1 - 6 7.2 19.7 1.2 9.5 2.2 5.2 5 2 1 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 ALMT PF11744.8 ETO13340.1 - 0.34 9.7 8.5 0.37 9.6 8.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 ETO13340.1 - 5.8 6.0 5.9 7 5.8 5.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETO13340.1 - 5.8 6.1 11.4 7.4 5.8 11.4 1.1 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO13340.1 - 5.9 5.6 8.3 6.4 5.4 8.3 1.0 1 0 0 1 1 1 0 Presenilin FYVE PF01363.21 ETO13341.1 - 4.8e-07 29.8 1.3 3.2e-06 27.2 1.3 2.5 1 0 0 1 1 1 1 FYVE zinc finger Dapper PF15268.6 ETO13342.1 - 0.0046 15.9 9.2 0.0075 15.2 9.2 1.4 1 0 0 1 1 1 1 Dapper HCO3_cotransp PF00955.21 ETO13342.1 - 3.7 6.3 9.8 7.6 5.2 9.8 1.7 1 0 0 1 1 1 0 HCO3- transporter family Saf_2TM PF18303.1 ETO13343.1 - 4.4 6.9 5.2 0.28 10.8 0.2 1.5 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain RGS PF00615.19 ETO13344.1 - 2.8e-05 24.4 1.5 2.8e-05 24.4 1.5 2.5 2 1 0 2 2 2 1 Regulator of G protein signaling domain BUD22 PF09073.10 ETO13344.1 - 0.0061 16.0 26.8 0.0047 16.3 7.8 2.1 2 0 0 2 2 2 2 BUD22 TMEM247 PF15444.6 ETO13344.1 - 1.8 8.5 7.8 0.11 12.5 0.9 2.2 2 0 0 2 2 2 0 Transmembrane protein 247 TFIIF_alpha PF05793.12 ETO13344.1 - 3.3 6.2 39.2 0.48 9.0 16.8 2.2 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 ETO13344.1 - 6.8 4.8 32.3 3.3 5.8 10.1 2.1 2 0 0 2 2 2 0 Nop14-like family DUF3973 PF13119.6 ETO13345.1 - 3 8.0 5.4 0.51 10.5 0.4 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3973) KN_motif PF12075.8 ETO13346.1 - 0.042 13.7 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 KN motif RRM_1 PF00076.22 ETO13347.1 - 2e-08 34.0 0.0 4e-08 33.0 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NUP50 PF08911.11 ETO13350.1 - 0.015 16.0 4.3 0.072 13.8 4.3 2.2 1 1 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) DUF3718 PF12514.8 ETO13350.1 - 0.15 12.3 0.0 0.29 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3718) Hid1 PF12722.7 ETO13350.1 - 1.6 6.7 7.5 1.9 6.5 7.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ribosomal_60s PF00428.19 ETO13352.1 - 0.0039 17.7 5.9 0.0039 17.7 5.9 2.3 2 0 0 2 2 2 1 60s Acidic ribosomal protein Neur_chan_memb PF02932.16 ETO13352.1 - 4.1 7.4 7.6 1.3 9.0 3.7 2.1 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Spa1_C PF18218.1 ETO13353.1 - 0.83 10.1 4.8 4.9 7.6 1.5 2.1 1 1 1 2 2 2 0 Lantibiotic immunity protein Spa1 C-terminal domain SGL PF08450.12 ETO13354.1 - 8.6e-07 28.8 1.1 0.0032 17.1 0.0 3.3 1 1 1 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region UPF0203 PF05254.12 ETO13355.1 - 2.3e-05 24.6 8.3 2.3e-05 24.6 8.3 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0203) UCR_hinge PF02320.16 ETO13355.1 - 0.012 15.8 2.9 0.027 14.7 2.9 1.6 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase hinge protein VitD-bind_III PF09164.10 ETO13355.1 - 0.027 14.5 0.3 0.098 12.7 0.3 1.9 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Tnp_22_trimer PF17489.2 ETO13355.1 - 0.18 11.8 0.4 0.18 11.8 0.4 2.2 2 0 0 2 2 2 0 L1 transposable element trimerization domain Cmc1 PF08583.10 ETO13355.1 - 0.29 11.2 6.0 1.7 8.7 0.8 2.6 1 1 1 2 2 2 0 Cytochrome c oxidase biogenesis protein Cmc1 like Pet191_N PF10203.9 ETO13355.1 - 0.97 9.8 6.8 7.2 7.0 1.8 2.5 1 1 1 2 2 2 0 Cytochrome c oxidase assembly protein PET191 SNARE PF05739.19 ETO13356.1 - 0.014 15.4 0.0 0.024 14.6 0.0 1.4 1 0 0 1 1 1 0 SNARE domain ThrE PF06738.12 ETO13356.1 - 0.056 12.8 0.0 0.058 12.8 0.0 1.1 1 0 0 1 1 1 0 Putative threonine/serine exporter PorA PF11271.8 ETO13356.1 - 0.092 12.0 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Porin PorA DUF2615 PF11027.8 ETO13357.1 - 0.0011 19.0 0.5 1.9 8.7 0.0 2.6 3 0 0 3 3 3 2 Protein of unknown function (DUF2615) Mucin PF01456.17 ETO13358.1 - 0.13 12.2 22.0 0.04 13.9 18.9 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein CYYR1 PF10873.8 ETO13358.1 - 0.56 10.7 2.6 1.1 9.7 2.6 1.6 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 FSA_C PF10479.9 ETO13358.1 - 2.6 6.1 9.3 3.4 5.7 9.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 ETO13358.1 - 8.6 4.4 16.7 14 3.7 16.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Alba PF01918.21 ETO13359.1 - 0.0023 17.7 0.2 0.005 16.6 0.2 1.5 1 0 0 1 1 1 1 Alba Actin PF00022.19 ETO13360.1 - 6.1e-19 67.9 0.0 7.5e-19 67.6 0.0 1.0 1 0 0 1 1 1 1 Actin Actin PF00022.19 ETO13361.1 - 1.4e-72 244.6 0.0 1.3e-55 188.7 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 ETO13361.1 - 0.0046 15.8 0.0 0.0092 14.8 0.0 1.4 1 1 0 1 1 1 1 MreB/Mbl protein Arm PF00514.23 ETO13363.1 - 1.5e-10 40.7 0.3 3.2e-05 23.8 0.0 2.8 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Dynamitin PF04912.14 ETO13363.1 - 1.6e-10 40.9 2.4 1.6e-10 40.9 2.4 1.9 2 0 0 2 2 2 1 Dynamitin eIF-4B PF06273.11 ETO13363.1 - 0.00048 19.3 0.7 0.00072 18.7 0.7 1.2 1 0 0 1 1 1 1 Plant specific eukaryotic initiation factor 4B Mo-nitro_C PF06967.11 ETO13364.1 - 0.021 14.8 0.0 0.051 13.6 0.0 1.6 2 0 0 2 2 2 0 Mo-dependent nitrogenase C-terminus Glyco_transf_49 PF13896.6 ETO13365.1 - 0.00081 18.8 0.4 0.00081 18.8 0.4 2.0 2 1 1 3 3 3 1 Glycosyl-transferase for dystroglycan DUF5580 PF17743.1 ETO13366.1 - 0.0098 14.5 4.8 0.01 14.4 4.8 1.0 1 0 0 1 1 1 1 Family of unknown function (DUF5580) Cnd2 PF05786.14 ETO13366.1 - 0.017 13.9 6.0 0.016 13.9 6.0 1.2 1 0 0 1 1 1 0 Condensin complex subunit 2 DUF4607 PF15380.6 ETO13366.1 - 0.085 12.3 0.6 0.082 12.4 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4607) CDC45 PF02724.14 ETO13366.1 - 0.18 10.0 8.8 0.18 10.1 8.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO13366.1 - 0.25 9.4 4.8 0.24 9.4 4.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 ETO13366.1 - 5.1 5.8 4.6 5.1 5.8 4.6 1.1 1 0 0 1 1 1 0 Presenilin GEN1_C PF18380.1 ETO13366.1 - 8 7.4 9.1 3.7 8.5 6.9 1.6 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain PBP1_TM PF14812.6 ETO13366.1 - 8.7 6.8 17.0 0.57 10.6 10.3 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PIN_4 PF13638.6 ETO13367.1 - 6.7 7.0 6.4 30 4.9 6.4 1.9 1 1 0 1 1 1 0 PIN domain T4_gp9_10 PF07880.11 ETO13368.1 - 0.0081 15.8 0.1 0.013 15.1 0.1 1.3 1 0 0 1 1 1 1 Bacteriophage T4 gp9/10-like protein FLYWCH PF04500.16 ETO13368.1 - 0.028 14.5 7.5 0.046 13.8 0.6 2.7 3 0 0 3 3 3 0 FLYWCH zinc finger domain Sigma70_ner PF04546.13 ETO13368.1 - 0.028 14.3 1.5 0.044 13.7 1.5 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Nop14 PF04147.12 ETO13368.1 - 0.051 11.8 7.0 0.067 11.4 7.0 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ETO13368.1 - 0.51 9.6 16.8 0.15 11.4 11.1 2.3 2 0 0 2 2 2 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO13368.1 - 0.71 10.3 19.0 1.6 9.2 19.0 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Utp14 PF04615.13 ETO13368.1 - 1.2 7.6 9.6 1.5 7.3 9.6 1.1 1 0 0 1 1 1 0 Utp14 protein DUF2457 PF10446.9 ETO13368.1 - 1.8 7.6 20.3 0.18 10.9 16.1 1.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) GP67 PF17634.2 ETO13368.1 - 3.2 8.2 21.7 6.3 7.3 21.7 1.4 1 0 0 1 1 1 0 Gene product 67 ANAPC15 PF15243.6 ETO13368.1 - 5.2 7.5 16.7 15 6.1 16.7 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 Peptidase_M13_N PF05649.13 ETO13369.1 - 8.8e-07 28.9 3.1 1.5e-06 28.2 3.1 1.4 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13 PF01431.21 ETO13370.1 - 1.3e-39 135.9 3.0 2.1e-38 132.0 3.0 2.1 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 ETO13370.1 - 7.7e-08 32.4 0.0 1.1e-07 31.8 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 ERCC4 PF02732.15 ETO13372.1 - 3.1e-23 82.7 0.6 4.8e-23 82.1 0.6 1.3 1 0 0 1 1 1 1 ERCC4 domain zf-C2H2 PF00096.26 ETO13373.1 - 0.9 10.1 9.0 0.1 13.1 2.8 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-Di19 PF05605.12 ETO13373.1 - 1.8 9.0 6.8 1.1 9.7 2.5 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ETO13373.1 - 2.1 9.4 8.1 0.85 10.6 3.5 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger TMEM144 PF07857.12 ETO13375.1 - 1.4e-17 63.7 15.8 1.7e-12 47.0 0.4 2.9 3 1 0 3 3 3 2 Transmembrane family, TMEM144 of transporters NAD_binding_6 PF08030.12 ETO13376.1 - 0.037 14.1 2.9 2.8 8.0 0.1 2.9 2 1 0 2 2 2 0 Ferric reductase NAD binding domain Vps39_2 PF10367.9 ETO13376.1 - 0.062 13.7 2.7 0.18 12.2 0.0 3.0 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 2 Blo-t-5 PF11642.8 ETO13376.1 - 0.23 11.4 4.4 1 9.3 1.3 2.7 2 0 0 2 2 2 0 Mite allergen Blo t 5 zf-RING_5 PF14634.6 ETO13376.1 - 1 9.4 5.3 0.54 10.3 1.5 2.2 2 0 0 2 2 2 0 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO13376.1 - 2 8.3 6.2 0.39 10.6 2.1 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO13376.1 - 2.4 8.6 4.2 2.9 8.3 1.5 2.3 2 0 0 2 2 2 0 Ring finger domain YqeY PF09424.10 ETO13377.1 - 0.013 15.5 0.1 0.034 14.2 0.1 1.7 1 0 0 1 1 1 0 Yqey-like protein Cytadhesin_P30 PF07271.11 ETO13378.1 - 0.0095 15.5 0.0 0.011 15.3 0.0 1.0 1 0 0 1 1 1 1 Cytadhesin P30/P32 Bap31 PF05529.12 ETO13378.1 - 0.058 13.3 0.8 0.25 11.2 0.0 2.1 1 1 1 2 2 2 0 Bap31/Bap29 transmembrane region CLN3 PF02487.17 ETO13378.1 - 0.23 10.4 0.2 0.27 10.2 0.2 1.1 1 0 0 1 1 1 0 CLN3 protein SDA1 PF05285.12 ETO13379.1 - 0.0068 15.9 0.8 0.0068 15.9 0.8 1.1 1 0 0 1 1 1 1 SDA1 RRN3 PF05327.11 ETO13379.1 - 0.024 13.2 1.0 0.022 13.3 1.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ETRAMP PF09716.10 ETO13379.1 - 4.7 7.4 4.6 0.94 9.6 0.6 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF443 PF04276.12 ETO13381.1 - 0.052 13.3 0.4 0.052 13.3 0.4 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF443) MMPL PF03176.15 ETO13381.1 - 0.056 12.4 0.0 0.079 11.9 0.0 1.2 1 0 0 1 1 1 0 MMPL family YMF19 PF02326.15 ETO13381.1 - 0.4 11.5 6.2 0.28 12.0 4.1 1.8 2 0 0 2 2 2 0 Plant ATP synthase F0 TMEM237 PF15383.6 ETO13382.1 - 0.068 12.3 0.2 6.2 5.8 0.0 2.2 2 0 0 2 2 2 0 Transmembrane protein 237 Nop14 PF04147.12 ETO13383.1 - 0.0013 17.0 33.3 0.0013 17.0 33.3 1.0 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO13383.1 - 0.03 13.8 36.2 0.031 13.7 36.2 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ETO13383.1 - 0.089 12.1 33.2 0.1 11.9 33.2 1.2 1 0 0 1 1 1 0 BUD22 Rrn6 PF10214.9 ETO13383.1 - 0.61 8.5 13.5 0.67 8.4 13.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Zip PF02535.22 ETO13383.1 - 0.99 8.6 17.3 1.3 8.1 17.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO13383.1 - 3.4 5.8 35.1 4.6 5.4 35.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 ETO13383.1 - 4.6 5.3 20.1 4.7 5.2 20.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 ETO13383.1 - 5.5 5.9 18.7 6.4 5.7 18.7 1.2 1 0 0 1 1 1 0 Solute carrier family 12 LAP1C PF05609.12 ETO13383.1 - 5.9 5.9 22.0 6.2 5.8 22.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Kelch_1 PF01344.25 ETO13384.1 - 6.5e-08 32.0 2.9 0.0013 18.3 0.6 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO13384.1 - 2e-07 30.9 0.2 0.0034 17.4 0.1 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO13384.1 - 5.4e-06 26.5 2.3 2.2 8.7 0.7 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 ETO13384.1 - 4.2e-05 23.4 12.9 0.24 11.4 1.8 4.8 5 0 0 5 5 5 2 Kelch motif Glyoxal_oxid_N PF07250.11 ETO13384.1 - 0.00024 20.4 1.6 0.003 16.8 0.0 2.6 1 1 1 2 2 2 1 Glyoxal oxidase N-terminus Kelch_2 PF07646.15 ETO13384.1 - 0.00025 20.9 6.2 0.042 13.9 0.3 4.5 5 1 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO13384.1 - 0.0026 18.0 0.9 2 8.8 0.1 4.0 5 0 0 5 5 5 1 Galactose oxidase, central domain UPF0180 PF03698.13 ETO13384.1 - 0.091 12.9 0.3 4.4 7.6 0.0 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0180) Kelch_1 PF01344.25 ETO13385.1 - 4.6e-09 35.7 0.3 6.5e-06 25.6 0.1 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO13385.1 - 9.9e-09 35.2 2.4 0.0012 19.1 0.1 4.8 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO13385.1 - 4.7e-07 29.5 1.7 0.0085 16.0 0.2 5.0 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO13385.1 - 1.1e-05 25.4 0.2 0.0037 17.2 0.1 4.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO13385.1 - 0.00032 20.6 0.1 17 5.5 0.0 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO13385.1 - 0.097 13.0 0.3 2 8.8 0.0 3.3 4 0 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO13386.1 - 1.1e-36 124.1 30.4 2.4e-06 28.2 0.3 7.6 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13386.1 - 1.4e-11 44.5 1.3 1 9.7 0.0 5.8 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13386.1 - 1.3e-09 37.3 10.4 0.048 12.3 0.0 5.5 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO13386.1 - 0.00045 19.6 1.5 0.44 9.8 0.2 3.9 2 2 1 4 4 4 2 WD40-like domain Dynamitin PF04912.14 ETO13388.1 - 0.0064 15.9 4.9 0.0082 15.5 4.9 1.2 1 0 0 1 1 1 1 Dynamitin Tmemb_cc2 PF10267.9 ETO13389.1 - 1.3 8.1 11.0 1.6 7.8 11.0 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Vta1 PF04652.16 ETO13391.1 - 0.0094 15.9 0.5 0.059 13.3 0.2 2.2 1 1 1 2 2 2 1 Vta1 like TFIID_NTD2 PF04494.15 ETO13392.1 - 0.011 16.0 0.8 0.014 15.6 0.5 1.4 1 1 0 1 1 1 0 WD40 associated region in TFIID subunit, NTD2 domain D123 PF07065.14 ETO13393.1 - 6.8e-18 64.9 3.6 2.8e-17 62.8 0.5 2.1 2 0 0 2 2 2 2 D123 R2K_3 PF14243.6 ETO13393.1 - 9.9e-08 32.2 0.0 1.6e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 R2K_2 PF18299.1 ETO13393.1 - 2e-06 27.7 0.1 4.1e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 DUF1336 PF07059.12 ETO13394.1 - 1.5e-66 224.8 0.0 2.4e-66 224.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) SDA1 PF05285.12 ETO13394.1 - 0.009 15.5 18.6 0.012 15.0 18.6 1.1 1 0 0 1 1 1 1 SDA1 KAsynt_C_assoc PF16197.5 ETO13394.1 - 0.083 13.3 0.6 0.61 10.6 1.0 2.3 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension GREB1 PF15782.5 ETO13394.1 - 0.7 6.9 14.3 0.95 6.5 14.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GNAT_acetyltr_2 PF13718.6 ETO13394.1 - 0.7 9.2 6.2 0.22 10.9 1.1 2.4 1 1 1 2 2 2 0 GNAT acetyltransferase 2 Presenilin PF01080.17 ETO13394.1 - 0.82 8.4 9.4 1.5 7.5 9.4 1.5 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 ETO13394.1 - 1.1 8.7 12.3 0.83 9.0 9.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Exo_endo_phos PF03372.23 ETO13395.1 - 0.0053 16.3 0.1 0.028 13.9 0.1 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family GTP_EFTU PF00009.27 ETO13396.1 - 1.6e-46 158.3 0.0 1.6e-46 158.3 0.0 2.4 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D2 PF03144.25 ETO13396.1 - 5e-06 26.8 0.8 2.3e-05 24.7 0.8 2.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D3 PF03143.17 ETO13396.1 - 6.8e-06 26.4 0.4 6.8e-06 26.4 0.4 3.0 3 0 0 3 3 3 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ETO13396.1 - 0.0003 20.9 1.7 0.65 10.1 0.0 3.5 3 1 0 3 3 3 2 50S ribosome-binding GTPase cobW PF02492.19 ETO13396.1 - 0.015 14.9 0.1 4.5 6.8 0.0 3.0 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain FAM176 PF14851.6 ETO13396.1 - 7.9 6.1 14.1 11 5.7 2.7 2.5 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.14 ETO13396.1 - 8.5 6.1 27.7 0.48 10.2 8.0 2.5 2 0 0 2 2 2 0 Pox virus Ag35 surface protein RGS PF00615.19 ETO13397.1 - 7e-09 36.0 7.3 6.1e-08 33.0 7.3 2.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF2619 PF10942.8 ETO13397.1 - 0.93 9.6 3.0 8.5 6.5 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2619) RPEL PF02755.15 ETO13398.1 - 6.4e-13 47.9 14.2 0.00017 21.2 1.3 4.0 4 0 0 4 4 4 3 RPEL repeat Rotavirus_VP1 PF12289.8 ETO13398.1 - 0.015 14.3 0.1 0.021 13.9 0.1 1.1 1 0 0 1 1 1 0 Rotavirus VP1 C-terminal domain CBS PF00571.28 ETO13399.1 - 1.7e-13 50.8 0.1 1.9e-09 37.8 0.5 3.2 3 0 0 3 3 3 2 CBS domain PH_12 PF16457.5 ETO13399.1 - 0.031 14.8 0.8 0.092 13.3 0.5 1.9 2 1 0 2 2 2 0 Pleckstrin homology domain DUSP PF06337.12 ETO13400.1 - 5.8e-07 30.0 1.2 5.8e-07 30.0 1.2 2.1 2 1 0 2 2 2 1 DUSP domain CENP-B_dimeris PF09026.10 ETO13400.1 - 0.011 16.1 1.4 0.011 16.1 1.4 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain MecA PF05389.12 ETO13400.1 - 0.38 10.4 5.8 0.69 9.5 5.8 1.5 1 1 0 1 1 1 0 Negative regulator of genetic competence (MecA) RIC3 PF15361.6 ETO13400.1 - 5.8 7.3 6.4 5.8 7.3 0.3 2.2 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 WD40 PF00400.32 ETO13401.1 - 6.4e-14 52.1 3.8 2.6e-06 28.1 0.3 2.1 2 0 0 2 2 2 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO13401.1 - 0.051 12.3 0.2 0.052 12.3 0.2 1.1 1 0 0 1 1 1 0 Nup133 N terminal like VPS13 PF16908.5 ETO13402.1 - 5.3e-08 33.0 2.7 8.8e-08 32.2 2.7 1.4 1 0 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal AGOG PF09171.10 ETO13403.1 - 0.037 13.3 1.7 0.048 13.0 1.7 1.1 1 0 0 1 1 1 0 N-glycosylase/DNA lyase SCP1201-deam PF14428.6 ETO13403.1 - 0.069 13.0 0.4 0.092 12.6 0.4 1.2 1 0 0 1 1 1 0 SCP1.201-like deaminase DREV PF05219.12 ETO13403.1 - 0.093 11.8 0.1 0.84 8.7 0.0 2.0 1 1 0 2 2 2 0 DREV methyltransferase DUF1815 PF08844.10 ETO13405.1 - 0.0054 16.7 0.0 0.0062 16.5 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1815) LAP1C PF05609.12 ETO13406.1 - 0.96 8.5 16.6 0.043 12.9 8.1 2.0 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Sulfotransfer_4 PF17784.1 ETO13407.1 - 5e-18 65.7 0.1 4e-12 46.4 0.1 2.2 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO13407.1 - 0.017 15.5 0.0 4.2 7.7 0.0 2.2 2 0 0 2 2 2 0 Sulfotransferase family FAM176 PF14851.6 ETO13408.1 - 0.015 14.9 0.3 0.033 13.8 0.3 1.5 1 0 0 1 1 1 0 FAM176 family Fer4_16 PF13484.6 ETO13408.1 - 10 7.2 14.6 2.9 8.9 6.0 2.3 2 0 0 2 2 2 0 4Fe-4S double cluster binding domain DnaJ PF00226.31 ETO13409.1 - 4.3e-20 71.6 1.9 9e-20 70.6 1.9 1.6 1 0 0 1 1 1 1 DnaJ domain TPR_2 PF07719.17 ETO13409.1 - 3.2e-14 51.8 0.2 0.0012 18.7 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13409.1 - 4.6e-11 42.1 0.5 0.018 14.9 0.1 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO13409.1 - 3e-06 26.8 1.0 0.075 12.7 0.0 3.5 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO13409.1 - 0.00011 22.3 2.5 0.28 11.6 0.0 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13409.1 - 0.00032 20.7 3.6 1.2 9.5 0.1 4.2 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13409.1 - 0.0015 19.2 0.1 5.6 8.1 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat SdrG_C_C PF10425.9 ETO13409.1 - 0.027 14.5 0.5 0.052 13.6 0.1 1.7 1 1 0 1 1 1 0 C-terminus of bacterial fibrinogen-binding adhesin TPR_9 PF13371.6 ETO13409.1 - 0.12 12.5 0.1 1.5 9.0 0.1 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Lge1 PF11488.8 ETO13409.1 - 0.3 11.3 2.7 0.47 10.7 0.8 2.3 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 MIT PF04212.18 ETO13409.1 - 9.3 6.4 9.1 0.57 10.3 0.3 3.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain WD40 PF00400.32 ETO13410.1 - 5.4e-29 99.8 24.9 9.4e-07 29.5 0.9 7.7 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13410.1 - 1.2e-11 44.8 1.3 0.034 14.5 0.0 5.0 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13410.1 - 6.4e-09 35.0 1.4 0.022 13.4 0.1 4.5 4 1 1 5 5 5 3 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO13410.1 - 0.14 12.0 4.1 4.7 7.1 0.0 3.8 2 1 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain EF_assoc_1 PF08355.12 ETO13411.1 - 1.3e-07 31.1 0.2 2.7e-07 30.1 0.2 1.5 1 0 0 1 1 1 1 EF hand associated Ras PF00071.22 ETO13411.1 - 0.00044 19.9 0.0 0.001 18.7 0.0 1.6 1 0 0 1 1 1 1 Ras family Pox_A32 PF04665.12 ETO13411.1 - 0.018 14.5 0.4 0.018 14.5 0.4 1.5 2 0 0 2 2 2 0 Poxvirus A32 protein WD40 PF00400.32 ETO13412.1 - 0.00066 20.4 0.8 0.056 14.3 0.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Metallophos PF00149.28 ETO13413.1 - 3.8e-12 47.1 2.6 4.9e-12 46.8 2.6 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO13413.1 - 1.5e-08 35.0 0.6 1.8e-07 31.5 0.6 2.3 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain E1-E2_ATPase PF00122.20 ETO13414.1 - 1.1 8.7 3.5 1.2 8.7 0.3 2.2 1 1 1 2 2 2 0 E1-E2 ATPase Macoilin PF09726.9 ETO13415.1 - 0.016 13.8 30.0 0.019 13.5 30.0 1.1 1 0 0 1 1 1 0 Macoilin family UreE_C PF05194.12 ETO13415.1 - 0.88 10.1 16.1 0.058 13.9 8.3 2.4 2 0 0 2 2 2 0 UreE urease accessory protein, C-terminal domain Peptidase_S64 PF08192.11 ETO13415.1 - 7.9 4.8 23.3 10 4.5 23.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4551 PF15087.6 ETO13415.1 - 8.2 5.1 18.9 9.9 4.9 18.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) AF-4 PF05110.13 ETO13416.1 - 1.1 7.2 45.6 1.5 6.8 45.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Mod_r PF07200.13 ETO13417.1 - 0.0021 18.2 13.9 0.0021 18.2 13.9 3.2 2 1 1 3 3 3 1 Modifier of rudimentary (Mod(r)) protein CENP-H PF05837.12 ETO13417.1 - 0.016 15.6 13.3 0.016 15.6 13.3 3.6 3 1 1 4 4 4 0 Centromere protein H (CENP-H) ZYG-11_interact PF05884.12 ETO13417.1 - 5 6.5 7.1 0.37 10.2 0.3 2.1 2 0 0 2 2 2 0 Interactor of ZYG-11 AAA PF00004.29 ETO13419.1 - 1.4e-05 25.5 0.0 4.5e-05 23.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO13419.1 - 0.0011 18.8 0.0 0.0015 18.3 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ETO13419.1 - 0.0063 16.3 0.0 0.01 15.6 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_16 PF13191.6 ETO13419.1 - 0.012 16.0 0.0 0.07 13.5 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ETO13419.1 - 0.014 15.8 0.0 0.067 13.6 0.0 2.1 2 0 0 2 2 2 0 RNA helicase NACHT PF05729.12 ETO13419.1 - 0.049 13.5 0.0 0.15 12.0 0.0 1.8 2 0 0 2 2 2 0 NACHT domain AAA_29 PF13555.6 ETO13419.1 - 0.055 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ETO13419.1 - 0.058 13.1 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain TIP49 PF06068.13 ETO13419.1 - 0.071 12.3 0.2 0.15 11.2 0.1 1.6 1 1 0 1 1 1 0 TIP49 P-loop domain AAA_5 PF07728.14 ETO13419.1 - 0.074 13.0 0.0 0.61 10.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) SMC_N PF02463.19 ETO13419.1 - 0.088 12.2 0.0 0.16 11.4 0.0 1.5 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain HCV_NS2 PF01538.18 ETO13420.1 - 0.03 14.0 0.4 0.039 13.6 0.4 1.1 1 0 0 1 1 1 0 Hepatitis C virus non-structural protein NS2 RGS PF00615.19 ETO13421.1 - 5.1e-10 39.7 1.2 4e-08 33.5 1.2 2.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain Rsbr_N PF08678.10 ETO13421.1 - 0.059 13.5 0.9 5.3 7.1 0.2 2.7 2 0 0 2 2 2 0 Rsbr N terminal AMA-1 PF02430.15 ETO13421.1 - 0.11 11.4 0.1 0.17 10.8 0.1 1.3 1 0 0 1 1 1 0 Apical membrane antigen 1 TFIIA PF03153.13 ETO13422.1 - 0.013 15.5 12.2 0.013 15.5 12.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Miff PF05644.11 ETO13422.1 - 0.8 9.3 9.7 0.88 9.1 9.7 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Exo_endo_phos PF03372.23 ETO13423.1 - 0.017 14.7 0.0 0.071 12.6 0.0 2.1 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Folate_carrier PF01770.18 ETO13423.1 - 2.1 7.0 5.9 4.2 6.0 2.7 2.3 2 0 0 2 2 2 0 Reduced folate carrier U-box PF04564.15 ETO13424.1 - 2.7e-20 72.3 0.8 9.8e-20 70.5 0.1 2.4 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 ETO13424.1 - 0.022 14.6 0.2 0.067 13.0 0.2 1.8 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 ETO13424.1 - 0.12 12.5 0.0 0.3 11.3 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein TFIIA PF03153.13 ETO13424.1 - 0.23 11.4 34.3 0.0098 15.9 7.5 2.3 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit eRF1_1 PF03463.15 ETO13424.1 - 0.24 11.4 3.2 0.89 9.6 1.2 2.8 2 1 0 2 2 2 0 eRF1 domain 1 DUF4834 PF16118.5 ETO13424.1 - 3 8.8 0.0 3 8.8 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) SARAF PF06682.12 ETO13424.1 - 4.6 6.8 11.6 0.82 9.3 4.1 2.9 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis ABC_membrane PF00664.23 ETO13426.1 - 3.2e-14 53.2 12.9 4.3e-14 52.8 12.9 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF2981 PF11200.8 ETO13427.1 - 5.3 6.7 5.1 7.2 6.3 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Phage_Gp23 PF10669.9 ETO13429.1 - 0.97 9.8 9.5 0.08 13.3 4.8 1.6 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) NUDIX PF00293.28 ETO13430.1 - 2.4e-08 34.1 0.0 6.4e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 NUDIX domain Hydrolase_4 PF12146.8 ETO13430.1 - 5.8e-07 29.0 0.0 0.028 13.7 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETO13430.1 - 6.4e-06 25.8 0.0 1.7e-05 24.4 0.0 1.7 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETO13430.1 - 0.0011 18.8 0.9 1.1 9.0 0.1 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 ETO13430.1 - 0.0015 18.3 5.6 0.029 14.0 5.6 2.5 1 1 0 1 1 1 1 alpha/beta hydrolase fold DLH PF01738.18 ETO13430.1 - 0.04 13.5 0.0 0.11 12.0 0.0 1.7 1 0 0 1 1 1 0 Dienelactone hydrolase family FSH1 PF03959.13 ETO13430.1 - 0.1 12.2 0.4 0.35 10.5 0.0 2.1 2 0 0 2 2 2 0 Serine hydrolase (FSH1) Macoilin PF09726.9 ETO13430.1 - 0.12 10.9 11.7 0.21 10.1 11.7 1.3 1 0 0 1 1 1 0 Macoilin family ASF1_hist_chap PF04729.13 ETO13431.1 - 1e-56 191.1 0.2 1.2e-56 190.9 0.2 1.0 1 0 0 1 1 1 1 ASF1 like histone chaperone Pico_P1A PF02226.16 ETO13431.1 - 0.025 14.6 0.7 3 8.0 0.0 2.3 2 0 0 2 2 2 0 Picornavirus coat protein (VP4) Rhabdo_matrix PF03397.14 ETO13431.1 - 0.06 13.1 0.1 9.2 6.0 0.1 2.2 2 0 0 2 2 2 0 Rhabdovirus matrix protein GFA PF04828.14 ETO13432.1 - 0.00085 19.6 2.5 0.0016 18.8 0.7 2.2 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme HATPase_c_3 PF13589.6 ETO13432.1 - 0.00093 19.0 0.1 0.0032 17.3 0.0 2.1 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Gal-3-0_sulfotr PF06990.11 ETO13434.1 - 0.055 12.3 0.1 0.064 12.1 0.1 1.1 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase Serinc PF03348.15 ETO13436.1 - 1.6 7.5 3.7 2.1 7.2 3.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) GlnD_UR_UTase PF08335.11 ETO13437.1 - 0.074 13.1 0.1 0.26 11.4 0.1 1.8 2 0 0 2 2 2 0 GlnD PII-uridylyltransferase Cullin PF00888.22 ETO13438.1 - 3.1e-86 290.4 13.3 8.6e-81 272.4 6.1 2.1 2 0 0 2 2 2 2 Cullin family Cullin_Nedd8 PF10557.9 ETO13438.1 - 1.4e-24 85.9 0.3 1.4e-24 85.9 0.3 3.6 4 0 0 4 4 4 1 Cullin protein neddylation domain DUF3496 PF12001.8 ETO13438.1 - 0.047 14.1 0.9 0.17 12.2 0.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) Med15_fungi PF05397.12 ETO13438.1 - 0.12 12.6 4.1 0.075 13.3 0.9 2.3 2 0 0 2 2 2 0 Mediator complex subunit 15 SBF_like PF13593.6 ETO13440.1 - 2e-32 112.8 4.6 2.3e-32 112.6 4.6 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) SBF PF01758.16 ETO13440.1 - 0.00064 19.5 1.3 0.00096 18.9 0.7 1.6 1 1 0 1 1 1 1 Sodium Bile acid symporter family CarS-like PF01864.17 ETO13440.1 - 0.015 15.3 2.7 0.015 15.3 2.7 2.0 2 1 1 3 3 3 0 CDP-archaeol synthase DUF2085 PF09858.9 ETO13440.1 - 7.6 7.1 7.1 1 9.9 0.1 2.6 2 1 1 3 3 3 0 Predicted membrane protein (DUF2085) DUF2791 PF10923.8 ETO13441.1 - 0.0012 17.8 0.0 0.0016 17.4 0.0 1.1 1 0 0 1 1 1 1 P-loop Domain of unknown function (DUF2791) Pex2_Pex12 PF04757.14 ETO13441.1 - 0.019 14.6 0.2 0.026 14.1 0.2 1.1 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region CDO_I PF05995.12 ETO13443.1 - 1.3e-10 40.9 0.1 9.3e-10 38.1 0.1 2.1 1 1 0 1 1 1 1 Cysteine dioxygenase type I PCO_ADO PF07847.12 ETO13443.1 - 0.0075 15.7 0.0 0.017 14.6 0.0 1.6 2 0 0 2 2 2 1 PCO_ADO IFT46_B_C PF12317.8 ETO13443.1 - 0.12 12.1 0.2 0.2 11.4 0.2 1.4 1 1 0 1 1 1 0 Intraflagellar transport complex B protein 46 C terminal T2SSM PF04612.12 ETO13444.1 - 0.046 13.8 2.2 0.16 12.1 2.2 1.9 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein M NicO PF03824.16 ETO13444.1 - 0.16 11.3 0.5 0.29 10.4 0.5 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein WD40 PF00400.32 ETO13445.1 - 1.9e-63 208.9 23.3 6.2e-10 39.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13445.1 - 1.6e-16 60.4 2.2 0.0013 19.0 0.0 5.4 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13445.1 - 2.7e-14 52.9 2.9 0.00067 18.7 0.0 5.1 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO13445.1 - 4.1e-07 29.6 1.2 0.023 14.1 0.2 2.5 1 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO13445.1 - 3.8e-05 22.5 6.1 0.038 12.6 0.0 4.3 2 2 2 4 4 4 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO13445.1 - 0.00071 18.2 0.7 0.68 8.4 0.1 2.8 2 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO13445.1 - 0.0033 17.3 6.9 11 6.1 0.1 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO13445.1 - 0.0033 16.2 2.0 0.81 8.4 0.0 3.5 2 2 2 4 4 4 1 Nup133 N terminal like Colicin_E5 PF12106.8 ETO13445.1 - 0.033 14.5 0.3 0.16 12.3 0.4 2.0 2 0 0 2 2 2 0 Colicin E5 ribonuclease domain SBD PF17882.1 ETO13445.1 - 0.073 12.9 0.4 11 5.9 0.1 3.1 2 2 1 3 3 3 0 OAA-family lectin sugar binding domain Utp8 PF10395.9 ETO13445.1 - 0.094 11.2 0.2 2.7 6.4 0.0 2.6 2 1 1 3 3 3 0 Utp8 family Nop10p PF04135.12 ETO13445.1 - 0.18 11.8 0.0 4.5 7.4 0.0 2.8 3 0 0 3 3 3 0 Nucleolar RNA-binding protein, Nop10p family Fibrinogen_aC PF12160.8 ETO13446.1 - 0.11 12.4 0.3 0.24 11.3 0.3 1.5 1 0 0 1 1 1 0 Fibrinogen alpha C domain SOGA PF11365.8 ETO13446.1 - 0.56 11.4 3.8 2.5 9.3 0.2 2.7 3 0 0 3 3 3 0 Protein SOGA Apc15p PF05841.11 ETO13446.1 - 0.96 10.3 25.9 4.7 8.0 14.1 2.3 2 0 0 2 2 2 0 Apc15p protein Methyltransf_12 PF08242.12 ETO13446.1 - 1.2 9.9 5.9 12 6.7 0.9 2.4 2 0 0 2 2 2 0 Methyltransferase domain Raftlin PF15250.6 ETO13446.1 - 2.4 6.8 6.6 3.7 6.2 0.6 2.1 2 0 0 2 2 2 0 Raftlin TCP PF03634.13 ETO13446.1 - 2.6 8.6 9.3 4.6 7.8 4.0 2.2 2 0 0 2 2 2 0 TCP family transcription factor NST1 PF13945.6 ETO13446.1 - 3.1 7.8 21.6 5.5 7.0 5.4 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator Zip PF02535.22 ETO13446.1 - 8.3 5.5 12.9 1.5 7.9 6.1 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO13446.1 - 9.7 7.2 12.2 6.7 7.8 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF420 PF04238.12 ETO13447.1 - 0.011 16.0 8.3 0.16 12.3 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF420) SPC25 PF06703.11 ETO13447.1 - 0.63 9.8 7.0 1.3 8.8 0.9 2.4 2 0 0 2 2 2 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Mucin PF01456.17 ETO13449.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF2054 PF10218.9 ETO13450.1 - 0.026 14.6 2.6 1.5 8.9 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2054) GAS PF13851.6 ETO13450.1 - 0.047 13.0 3.5 0.078 12.3 3.5 1.4 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Gal4_dimer PF03902.13 ETO13450.1 - 0.055 13.6 0.6 0.22 11.7 0.1 2.3 2 0 0 2 2 2 0 Gal4-like dimerisation domain PMC2NT PF08066.12 ETO13450.1 - 0.081 13.6 3.7 0.11 13.2 0.1 2.6 3 1 0 3 3 3 0 PMC2NT (NUC016) domain TGF_beta PF00019.20 ETO13450.1 - 0.11 13.5 2.1 11 7.0 0.1 2.3 2 0 0 2 2 2 0 Transforming growth factor beta like domain DUF2935 PF11155.8 ETO13450.1 - 3.1 8.1 7.3 0.29 11.5 0.9 2.4 3 1 0 3 3 3 0 Domain of unknown function (DUF2935) PRP38_assoc PF12871.7 ETO13451.1 - 0.018 15.7 18.0 0.018 15.7 18.0 1.8 3 0 0 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Atrophin-1 PF03154.15 ETO13451.1 - 0.3 9.3 4.9 0.38 9.0 4.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 ETO13451.1 - 0.45 10.5 8.8 0.08 12.9 3.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) HECT PF00632.25 ETO13452.1 - 1.4e-33 116.7 4.0 1.9e-33 116.2 2.2 1.9 2 1 0 2 2 2 1 HECT-domain (ubiquitin-transferase) AKAP_110 PF05716.13 ETO13455.1 - 0.024 12.9 0.1 0.037 12.3 0.1 1.2 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) CagS PF16707.5 ETO13455.1 - 0.047 13.7 0.0 0.2 11.7 0.0 1.9 2 0 0 2 2 2 0 Cag pathogenicity island protein S of Helicobacter pylori PKD_2 PF16407.5 ETO13455.1 - 0.078 13.2 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 PKD-like family LMWPc PF01451.21 ETO13456.1 - 0.007 16.8 1.4 0.012 16.0 0.2 2.0 2 1 1 3 3 3 1 Low molecular weight phosphotyrosine protein phosphatase TOM13 PF08219.11 ETO13456.1 - 0.92 9.5 0.0 0.92 9.5 0.0 2.6 3 0 0 3 3 3 0 Outer membrane protein TOM13 SDP_N PF12278.8 ETO13456.1 - 3.9 7.6 12.8 5.3 7.2 11.7 1.8 1 1 0 1 1 1 0 Sex determination protein N terminal DUF2312 PF10073.9 ETO13459.1 - 0.045 13.4 0.8 0.045 13.4 0.8 2.1 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2312) RVP PF00077.20 ETO13460.1 - 0.11 12.9 0.0 0.27 11.5 0.0 1.7 1 0 0 1 1 1 0 Retroviral aspartyl protease WD40 PF00400.32 ETO13462.1 - 1.7e-32 110.9 11.0 2.4e-09 37.6 0.2 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13462.1 - 7.7e-08 32.5 3.1 1.1 9.5 0.0 6.7 2 1 6 8 8 8 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO13462.1 - 0.00022 21.4 7.4 0.25 11.7 0.0 4.8 5 0 0 5 5 5 2 Kelch motif PD40 PF07676.12 ETO13462.1 - 0.011 15.7 3.6 2.2 8.3 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Kelch_1 PF01344.25 ETO13462.1 - 0.06 12.9 1.0 5.9 6.6 0.1 3.3 3 0 0 3 3 3 0 Kelch motif DUF4763 PF15960.5 ETO13462.1 - 0.12 11.6 3.7 0.21 10.8 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Cullin PF00888.22 ETO13463.1 - 1.1e-106 357.9 22.3 7.3e-49 166.9 8.0 4.4 2 2 1 3 3 3 3 Cullin family Lipid_bd PF12888.7 ETO13463.1 - 0.17 12.3 0.5 0.67 10.4 0.4 2.1 1 1 1 2 2 2 0 Lipid-binding putative hydrolase Cullin_Nedd8 PF10557.9 ETO13464.1 - 1.5e-24 85.8 4.4 2.5e-24 85.1 4.4 1.4 1 0 0 1 1 1 1 Cullin protein neddylation domain CRAL_TRIO_N PF03765.15 ETO13464.1 - 0.0062 16.7 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 CRAL/TRIO, N-terminal domain DUF3658 PF12395.8 ETO13464.1 - 0.054 13.4 0.3 0.086 12.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function Phage_CI_repr PF07022.13 ETO13468.1 - 0.17 12.0 0.0 0.32 11.1 0.0 1.5 1 0 0 1 1 1 0 Bacteriophage CI repressor helix-turn-helix domain HA PF03457.14 ETO13469.1 - 0.11 12.8 0.9 0.43 11.0 0.0 2.4 2 0 0 2 2 2 0 Helicase associated domain UPF0061 PF02696.14 ETO13469.1 - 1.2 7.8 7.5 0.34 9.6 4.1 1.7 2 0 0 2 2 2 0 Uncharacterized ACR, YdiU/UPF0061 family DUF5069 PF16798.5 ETO13470.1 - 0.0075 16.5 2.2 0.011 16.0 2.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5069) ParB PF08775.10 ETO13470.1 - 0.02 15.4 5.4 0.02 15.4 5.4 2.1 1 1 1 2 2 2 0 ParB family PBECR5 PF18814.1 ETO13470.1 - 0.045 13.7 6.6 0.054 13.4 6.6 1.2 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease5 TcpS PF17456.2 ETO13470.1 - 0.047 13.7 7.3 0.11 12.5 6.3 1.8 1 1 1 2 2 2 0 Toxin-coregulated pilus protein S DUF87 PF01935.17 ETO13470.1 - 0.079 13.0 4.3 0.11 12.6 4.1 1.3 1 1 0 1 1 1 0 Helicase HerA, central domain Prominin PF05478.11 ETO13470.1 - 0.089 10.7 9.9 0.1 10.5 9.9 1.0 1 0 0 1 1 1 0 Prominin Fucose_iso_N2 PF07882.12 ETO13470.1 - 0.11 12.1 3.7 0.13 11.8 3.7 1.1 1 0 0 1 1 1 0 L-fucose isomerase, second N-terminal domain THP2 PF09432.10 ETO13470.1 - 0.15 12.1 8.1 2.9 7.9 8.0 2.2 1 1 0 1 1 1 0 Tho complex subunit THP2 DUF2203 PF09969.9 ETO13470.1 - 0.23 12.2 6.3 0.27 11.9 5.1 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Atg14 PF10186.9 ETO13470.1 - 0.24 10.4 11.3 0.31 10.1 11.3 1.2 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1974 PF09317.11 ETO13470.1 - 0.27 10.8 4.6 0.33 10.5 4.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1974) TMPIT PF07851.13 ETO13470.1 - 0.43 9.8 10.2 0.36 10.0 9.2 1.3 1 1 0 1 1 1 0 TMPIT-like protein zf-CRD PF17979.1 ETO13470.1 - 0.49 10.5 4.4 0.51 10.4 3.6 1.4 1 1 0 1 1 1 0 Cysteine rich domain with multizinc binding regions DUF2785 PF10978.8 ETO13470.1 - 0.51 10.1 5.4 0.39 10.5 3.6 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2785) Fib_alpha PF08702.10 ETO13470.1 - 0.52 10.5 16.8 0.097 12.8 7.4 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF3349 PF11829.8 ETO13470.1 - 0.55 11.0 5.0 0.22 12.3 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) IZUMO PF15005.6 ETO13470.1 - 1.7 9.2 9.9 2.3 8.7 9.9 1.2 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Cauli_AT PF03233.13 ETO13470.1 - 1.9 8.4 11.0 1.2 9.1 8.3 1.9 1 1 1 2 2 2 0 Aphid transmission protein DUF16 PF01519.16 ETO13470.1 - 2.5 8.6 13.5 7 7.2 13.4 2.0 1 1 0 1 1 1 0 Protein of unknown function DUF16 LMBR1 PF04791.16 ETO13470.1 - 3.4 6.5 6.9 3.9 6.3 6.9 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein GPHR_N PF12537.8 ETO13470.1 - 4.4 7.5 5.1 7.9 6.6 1.0 2.7 2 1 0 2 2 2 0 The Golgi pH Regulator (GPHR) Family N-terminal DUF948 PF06103.11 ETO13470.1 - 7.4 6.9 9.9 4.9 7.5 2.9 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Dynamin_N PF00350.23 ETO13471.1 - 3.5e-13 50.0 0.0 4.6e-11 43.1 0.0 2.2 1 1 0 1 1 1 1 Dynamin family EHD_N PF16880.5 ETO13471.1 - 5.3e-11 42.2 0.5 5.3e-11 42.2 0.5 1.8 2 0 0 2 2 2 1 N-terminal EH-domain containing protein MMR_HSR1 PF01926.23 ETO13471.1 - 1.1e-06 28.8 0.0 2.1e-06 27.8 0.0 1.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_28 PF13521.6 ETO13471.1 - 0.024 14.9 0.0 0.052 13.8 0.0 1.5 2 0 0 2 2 2 0 AAA domain DUF927 PF06048.11 ETO13471.1 - 0.11 12.1 0.0 0.15 11.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF927) TsaE PF02367.17 ETO13471.1 - 0.14 12.1 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Septin PF00735.18 ETO13471.1 - 0.18 11.1 0.0 0.28 10.4 0.0 1.4 1 0 0 1 1 1 0 Septin Hydrolase_4 PF12146.8 ETO13472.1 - 6.4e-11 42.0 0.0 3.7e-06 26.4 0.1 3.3 2 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO13472.1 - 4.5e-05 24.2 0.0 7.1e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ETO13472.1 - 4.8e-05 23.1 0.0 0.00011 21.9 0.0 1.7 2 0 0 2 2 2 1 Putative esterase Menin PF05053.13 ETO13472.1 - 0.00055 18.5 9.0 0.0048 15.3 3.4 2.1 2 0 0 2 2 2 2 Menin DLH PF01738.18 ETO13472.1 - 0.0039 16.8 0.4 2.6 7.5 0.0 2.7 2 1 0 2 2 2 2 Dienelactone hydrolase family Myc_N PF01056.18 ETO13472.1 - 0.0091 15.9 0.6 0.0091 15.9 0.6 1.6 2 0 0 2 2 2 1 Myc amino-terminal region UPF0227 PF05728.12 ETO13472.1 - 0.018 15.0 0.3 0.036 14.0 0.3 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Esterase_phd PF10503.9 ETO13472.1 - 0.033 13.7 0.0 0.054 13.0 0.0 1.3 1 0 0 1 1 1 0 Esterase PHB depolymerase PGAP1 PF07819.13 ETO13472.1 - 0.11 12.2 0.2 0.11 12.2 0.2 2.1 1 1 1 2 2 2 0 PGAP1-like protein DUF3402 PF11882.8 ETO13472.1 - 0.17 10.9 4.9 0.078 12.1 2.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3402) MID_MedPIWI PF18296.1 ETO13472.1 - 0.2 11.4 11.8 1.7 8.4 11.2 2.2 1 1 0 1 1 1 0 MID domain of medPIWI DUF3439 PF11921.8 ETO13472.1 - 0.45 10.5 5.2 1 9.4 5.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ATAD4 PF15321.6 ETO13472.1 - 3.1 9.2 8.3 19 6.6 3.6 2.7 3 0 0 3 3 3 0 ATPase family AAA domain containing 4 Ion_trans PF00520.31 ETO13473.1 - 6.4e-11 42.0 1.9 9e-11 41.5 1.9 1.2 1 0 0 1 1 1 1 Ion transport protein DUF4097 PF13349.6 ETO13474.1 - 0.013 14.9 0.0 0.022 14.1 0.0 1.4 1 1 0 1 1 1 0 Putative adhesin Peptidase_S9 PF00326.21 ETO13474.1 - 0.18 11.2 0.1 0.3 10.5 0.1 1.3 1 0 0 1 1 1 0 Prolyl oligopeptidase family WD40 PF00400.32 ETO13475.1 - 7e-25 86.8 26.5 1.6e-06 28.7 0.2 7.1 6 1 0 6 6 6 5 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO13475.1 - 1.5e-07 32.0 2.5 8.8e-07 29.5 2.5 2.4 1 0 0 1 1 1 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO13475.1 - 0.00039 20.7 4.1 2.7 8.4 0.0 5.9 5 3 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain SH3_13 PF18335.1 ETO13475.1 - 2.7 7.9 13.1 0.81 9.6 0.8 4.3 3 2 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain PX PF00787.24 ETO13476.1 - 0.00029 20.8 0.4 0.00029 20.8 0.4 2.8 4 0 0 4 4 4 1 PX domain Solute_trans_a PF03619.16 ETO13477.1 - 4.3e-15 56.0 12.6 7.7e-15 55.1 12.6 1.5 1 1 0 1 1 1 1 Organic solute transporter Ostalpha Rcd1 PF04078.13 ETO13478.1 - 2.2e-83 279.5 2.4 1.4e-44 152.3 1.9 3.7 2 2 0 2 2 2 2 Cell differentiation family, Rcd1-like DUF3385 PF11865.8 ETO13478.1 - 0.13 12.1 1.2 0.25 11.2 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3385) UPF0239 PF06783.11 ETO13479.1 - 0.068 13.4 3.1 0.11 12.7 3.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) zf-RanBP PF00641.18 ETO13480.1 - 1.8e-06 27.2 1.1 3.9e-06 26.1 1.1 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Ran_BP1 PF00638.18 ETO13480.1 - 0.00045 20.5 0.5 0.012 15.9 0.3 2.8 2 1 0 2 2 2 1 RanBP1 domain Rubredoxin_2 PF18073.1 ETO13480.1 - 0.072 12.8 0.1 0.072 12.8 0.1 2.0 2 0 0 2 2 2 0 Rubredoxin metal binding domain zf-Sec23_Sec24 PF04810.15 ETO13480.1 - 0.26 11.4 3.3 0.67 10.0 0.5 2.5 1 1 1 2 2 2 0 Sec23/Sec24 zinc finger Pentapeptide PF00805.22 ETO13482.1 - 1e-40 136.9 30.5 4e-09 35.9 3.5 6.2 3 2 3 7 7 7 6 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO13482.1 - 2.2e-29 101.4 30.8 2.3e-09 37.3 3.2 5.1 2 2 3 5 5 5 5 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO13482.1 - 1.5e-21 76.3 21.1 7.2e-06 26.1 0.4 5.9 3 1 2 5 5 5 5 Pentapeptide repeats (9 copies) CfAFP PF05264.11 ETO13482.1 - 0.0064 16.5 4.6 0.32 11.0 0.2 3.0 2 1 1 3 3 3 2 Choristoneura fumiferana antifreeze protein (CfAFP) DUF5537 PF17690.1 ETO13482.1 - 0.38 10.4 3.6 1.8 8.2 0.2 2.5 2 1 1 3 3 3 0 Family of unknown function (DUF5537) Pentapeptide PF00805.22 ETO13483.1 - 3.4e-19 68.1 8.2 4.5e-09 35.8 0.2 3.3 1 1 1 3 3 3 3 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO13483.1 - 3.7e-13 49.4 5.6 2.6e-11 43.5 4.8 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO13483.1 - 3.6e-09 36.6 5.8 4.1e-08 33.3 1.7 2.9 2 1 1 3 3 3 2 Pentapeptide repeats (9 copies) HIP1_clath_bdg PF16515.5 ETO13483.1 - 0.032 14.8 9.2 0.032 14.8 9.2 2.5 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Atg14 PF10186.9 ETO13483.1 - 3.5 6.6 16.6 6 5.9 16.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1465 PF07323.12 ETO13483.1 - 5.7 6.8 12.5 1.6 8.5 6.9 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1465) Spc7 PF08317.11 ETO13483.1 - 8.2 5.2 28.9 5.5 5.8 12.6 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein RNase_H PF00075.24 ETO13485.1 - 0.0085 16.3 0.1 0.016 15.4 0.1 1.4 1 0 0 1 1 1 1 RNase H DUF996 PF06195.13 ETO13486.1 - 7.5 6.8 11.3 0.21 11.9 3.0 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF996) Nse4_C PF08743.10 ETO13488.1 - 2.1e-23 82.4 1.9 4.7e-23 81.3 0.1 2.3 2 0 0 2 2 2 1 Nse4 C-terminal Host_attach PF10116.9 ETO13488.1 - 0.031 14.9 0.4 0.062 13.9 0.0 1.6 2 0 0 2 2 2 0 Protein required for attachment to host cells DUF5321 PF17254.2 ETO13489.1 - 0.029 13.8 4.1 0.033 13.6 4.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5321) NUDIX PF00293.28 ETO13489.1 - 0.032 14.3 0.2 0.036 14.1 0.2 1.2 1 0 0 1 1 1 0 NUDIX domain Ycf1 PF05758.12 ETO13489.1 - 0.33 8.8 3.1 0.38 8.6 3.1 1.0 1 0 0 1 1 1 0 Ycf1 Cytomega_UL84 PF06284.11 ETO13489.1 - 0.54 8.7 1.9 0.52 8.7 1.9 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PH PF00169.29 ETO13490.1 - 6.4e-15 55.6 3.4 2.2e-06 28.1 0.8 2.5 1 1 1 2 2 2 2 PH domain PH_11 PF15413.6 ETO13490.1 - 7.3e-06 26.4 4.7 0.0013 19.1 2.6 2.7 2 1 0 2 2 2 2 Pleckstrin homology domain PH_8 PF15409.6 ETO13490.1 - 0.00026 21.2 0.3 0.0085 16.3 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 ETO13490.1 - 0.024 15.0 0.0 0.051 13.9 0.0 1.5 1 0 0 1 1 1 0 Plant pleckstrin homology-like region ATG16 PF08614.11 ETO13490.1 - 0.027 14.7 0.6 0.052 13.8 0.6 1.4 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4663 PF15668.5 ETO13490.1 - 0.028 13.5 0.5 0.038 13.1 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) DUF1908 PF08926.11 ETO13490.1 - 0.095 11.8 5.6 0.31 10.1 3.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1908) CCSAP PF15748.5 ETO13490.1 - 0.16 12.1 6.3 0.25 11.5 6.3 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated SR-25 PF10500.9 ETO13490.1 - 2.2 7.8 13.7 2.1 7.9 11.2 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 ETO13490.1 - 6.3 7.4 17.3 0.87 10.2 13.2 1.7 2 0 0 2 2 2 0 Secretin N-terminal domain IMUP PF15761.5 ETO13490.1 - 8.9 7.1 12.2 23 5.7 12.2 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF3683 PF12447.8 ETO13492.1 - 0.026 14.6 2.4 0.91 9.7 0.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3683) Choline_transpo PF04515.12 ETO13492.1 - 0.071 12.3 0.4 0.12 11.6 0.4 1.3 1 0 0 1 1 1 0 Plasma-membrane choline transporter Phosphodiest PF01663.22 ETO13493.1 - 5.9e-11 42.5 0.6 8.8e-11 42.0 0.6 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ETO13493.1 - 0.0057 16.1 0.5 0.0096 15.3 0.5 1.3 1 0 0 1 1 1 1 Metalloenzyme superfamily TRF PF08558.10 ETO13493.1 - 0.023 14.3 0.0 0.05 13.2 0.0 1.5 1 0 0 1 1 1 0 Telomere repeat binding factor (TRF) HetR_C PF18460.1 ETO13493.1 - 0.062 13.2 0.2 0.14 12.1 0.2 1.6 1 0 0 1 1 1 0 Heterocyst differentiation regulator C-terminal Hood domain 2-Hacid_dh_C PF02826.19 ETO13494.1 - 1.8e-17 63.3 0.1 2.7e-17 62.7 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Secretin_N_2 PF07655.13 ETO13495.1 - 0.38 11.3 10.5 4.9 7.8 0.4 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain TMEM132D_C PF15706.5 ETO13496.1 - 0.043 13.6 0.1 0.19 11.5 0.1 2.1 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term FAM60A PF15396.6 ETO13497.1 - 0.0075 16.3 4.3 0.009 16.0 4.3 1.1 1 0 0 1 1 1 1 Protein Family FAM60A Connexin PF00029.19 ETO13497.1 - 0.014 15.1 0.3 0.017 14.9 0.3 1.2 1 0 0 1 1 1 0 Connexin Orf78 PF06024.12 ETO13497.1 - 0.17 12.2 2.4 0.72 10.2 2.4 1.9 1 1 0 1 1 1 0 Orf78 (ac78) CDC45 PF02724.14 ETO13497.1 - 5.9 5.0 12.3 6.7 4.9 12.3 1.0 1 0 0 1 1 1 0 CDC45-like protein OST_P2 PF18235.1 ETO13498.1 - 0.03 14.3 0.0 0.064 13.2 0.0 1.7 1 0 0 1 1 1 0 Oligosaccharyltransferase Peripheral 2 domain ColG_sub PF18496.1 ETO13498.1 - 2.5 8.3 9.7 0.18 12.0 1.0 2.7 3 0 0 3 3 3 0 Collagenase G catalytic helper subdomain EF-hand_1 PF00036.32 ETO13499.1 - 1.3e-31 105.7 21.7 8.4e-08 31.2 0.8 4.2 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO13499.1 - 7.8e-28 96.7 15.1 7.6e-15 55.1 3.6 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO13499.1 - 1.5e-27 93.1 11.7 4.5e-08 32.4 0.1 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO13499.1 - 2.5e-22 77.3 19.4 1.8e-05 24.0 0.1 4.2 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO13499.1 - 6.6e-22 77.1 18.9 1.6e-10 40.7 3.1 4.0 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ETO13499.1 - 1.4e-14 54.1 1.8 1.5e-07 31.6 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO13499.1 - 7.2e-07 29.5 5.1 0.0059 16.9 0.7 2.1 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO13499.1 - 3e-06 27.1 17.0 0.0025 17.7 3.4 3.1 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 ETO13499.1 - 0.00044 20.5 2.3 0.19 12.1 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain DUF5580 PF17743.1 ETO13499.1 - 0.00052 18.7 0.0 0.0027 16.3 0.0 1.8 1 1 1 2 2 2 1 Family of unknown function (DUF5580) SurA_N_3 PF13624.6 ETO13499.1 - 0.00069 19.4 1.0 0.0031 17.3 0.1 2.0 1 1 1 2 2 2 1 SurA N-terminal domain TerB PF05099.13 ETO13499.1 - 0.00069 19.6 0.4 0.57 10.1 0.1 2.4 2 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_11 PF08976.11 ETO13499.1 - 0.0017 19.2 1.6 0.12 13.2 0.1 2.2 1 1 1 2 2 2 1 EF-hand domain SurA_N_2 PF13623.6 ETO13499.1 - 0.006 16.5 2.0 0.23 11.3 0.1 2.4 2 1 0 2 2 2 1 SurA N-terminal domain VbhA PF18495.1 ETO13499.1 - 0.012 15.5 0.7 0.29 11.0 0.2 3.1 3 1 0 3 3 3 0 Antitoxin VbhA Caleosin PF05042.13 ETO13499.1 - 0.016 15.2 1.3 2.8 7.8 0.0 3.3 2 2 1 3 3 3 0 Caleosin related protein EF-hand_10 PF14788.6 ETO13499.1 - 0.057 13.3 6.7 1.3 8.9 0.5 2.8 2 2 1 3 3 3 0 EF hand CH_2 PF06294.11 ETO13499.1 - 0.11 12.6 0.1 5.5 7.2 0.0 2.6 2 1 0 2 2 2 0 CH-like domain in sperm protein Dockerin_1 PF00404.18 ETO13499.1 - 2.5 8.3 7.9 0.63 10.3 0.6 2.8 2 1 0 2 2 2 0 Dockerin type I domain PseudoU_synth_2 PF00849.22 ETO13501.1 - 8.2e-23 81.2 0.1 8.2e-23 81.2 0.1 2.0 2 0 0 2 2 2 1 RNA pseudouridylate synthase Zip PF02535.22 ETO13501.1 - 0.061 12.5 0.5 0.078 12.2 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO13501.1 - 1.1 7.4 6.5 1.4 7.1 6.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 ETO13501.1 - 4 6.9 11.4 6.4 6.2 11.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 ETO13501.1 - 7.5 6.3 11.3 10 5.8 11.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TipAS PF07739.13 ETO13502.1 - 0.15 12.6 2.1 0.21 12.1 0.1 2.2 3 1 0 3 3 3 0 TipAS antibiotic-recognition domain DUF5129 PF17173.4 ETO13503.1 - 0.16 11.0 0.5 0.26 10.4 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) NUFIP1 PF10453.9 ETO13504.1 - 0.0035 17.2 0.9 0.0035 17.2 0.9 2.8 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) GIT_CC PF16559.5 ETO13505.1 - 0.12 12.2 0.1 0.25 11.2 0.1 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CAP_GLY PF01302.25 ETO13506.1 - 2.1e-12 46.9 5.0 6.5e-09 35.7 2.0 2.7 2 1 0 2 2 2 2 CAP-Gly domain Macoilin PF09726.9 ETO13506.1 - 2 6.9 14.0 2.6 6.5 14.0 1.1 1 0 0 1 1 1 0 Macoilin family Pyr_redox_2 PF07992.14 ETO13507.1 - 1.5e-16 60.5 0.3 1.6e-16 60.4 0.3 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_oxidored PF12831.7 ETO13507.1 - 3.4e-10 39.8 0.3 3.6e-10 39.8 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase GIDA PF01134.22 ETO13507.1 - 3.8e-10 39.4 0.7 4.5e-10 39.2 0.7 1.0 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ETO13507.1 - 1.5e-06 27.6 2.9 2.1e-06 27.1 2.9 1.1 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ETO13507.1 - 4.1e-05 23.7 0.7 5.6e-05 23.3 0.7 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETO13507.1 - 8e-05 22.0 0.0 8.9e-05 21.8 0.0 1.2 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ETO13507.1 - 0.00013 20.8 1.7 0.00017 20.4 1.7 1.1 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ETO13507.1 - 0.0012 18.1 2.5 0.002 17.5 2.5 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO13507.1 - 0.0034 17.9 0.5 0.0064 17.0 0.5 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETO13507.1 - 0.0064 16.1 0.3 0.0067 16.1 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase Lycopene_cycl PF05834.12 ETO13507.1 - 0.0085 15.2 0.1 0.0091 15.1 0.1 1.2 1 0 0 1 1 1 1 Lycopene cyclase protein FAD_binding_3 PF01494.19 ETO13507.1 - 0.13 11.5 1.4 0.17 11.1 1.4 1.1 1 0 0 1 1 1 0 FAD binding domain Pkinase PF00069.25 ETO13508.1 - 0.029 13.8 0.0 0.046 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain DUF4510 PF14971.6 ETO13509.1 - 0.016 15.5 1.2 0.061 13.7 1.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4510) DUF4407 PF14362.6 ETO13509.1 - 3.1 7.1 46.1 0.12 11.8 0.9 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4407) HalX PF08663.10 ETO13509.1 - 8.7 6.8 22.1 3.1 8.2 1.2 4.7 3 1 0 3 3 3 0 HalX domain Macoilin PF09726.9 ETO13510.1 - 0.47 9.0 14.4 0.64 8.5 14.4 1.1 1 0 0 1 1 1 0 Macoilin family TB2_DP1_HVA22 PF03134.19 ETO13510.1 - 0.66 10.0 5.8 0.34 10.9 3.1 1.9 2 0 0 2 2 2 0 TB2/DP1, HVA22 family CENP-B_dimeris PF09026.10 ETO13510.1 - 3.1 8.2 12.1 12 6.3 10.7 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Tub_N PF16322.5 ETO13510.1 - 5.3 7.4 20.1 0.067 13.6 9.0 2.2 1 1 1 2 2 2 0 Tubby N-terminal PHD_Oberon PF07227.11 ETO13511.1 - 0.008 16.1 2.5 0.0097 15.8 0.4 1.9 2 0 0 2 2 2 1 PHD - plant homeodomain finger protein DUF2243 PF10002.9 ETO13511.1 - 0.018 15.1 1.5 0.037 14.2 1.5 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2243) K1 PF02960.14 ETO13511.1 - 0.75 9.9 6.5 2.3 8.4 0.3 2.8 3 0 0 3 3 3 0 K1 glycoprotein Kinesin PF00225.23 ETO13512.1 - 1.1e-84 284.3 0.0 1.3e-84 284.0 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO13512.1 - 5e-27 94.7 0.0 7.3e-27 94.1 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding PhoH PF02562.16 ETO13512.1 - 0.16 11.4 0.2 0.32 10.4 0.2 1.5 1 1 0 1 1 1 0 PhoH-like protein SpoIIM PF01944.17 ETO13513.1 - 0.15 12.1 0.2 0.25 11.4 0.2 1.3 1 0 0 1 1 1 0 Stage II sporulation protein M Rhomboid PF01694.22 ETO13515.1 - 1.3e-11 44.7 0.2 1.3e-11 44.7 0.2 2.3 3 0 0 3 3 3 1 Rhomboid family DUF4834 PF16118.5 ETO13515.1 - 0.15 13.0 6.4 0.12 13.3 2.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DHHC PF01529.20 ETO13517.1 - 7.9e-06 26.0 49.2 0.00099 19.2 39.8 4.2 2 1 1 3 3 3 1 DHHC palmitoyltransferase ECF_trnsprt PF12822.7 ETO13517.1 - 0.00047 20.3 0.9 0.00047 20.3 0.9 2.5 2 1 0 2 2 2 1 ECF transporter, substrate-specific component CobD_Cbib PF03186.13 ETO13517.1 - 0.28 10.4 2.9 1.4 8.1 0.5 2.2 2 0 0 2 2 2 0 CobD/Cbib protein RNase_H PF00075.24 ETO13518.1 - 1.9e-18 67.0 0.0 3.4e-18 66.2 0.0 1.4 1 0 0 1 1 1 1 RNase H Lipase_GDSL_3 PF14606.6 ETO13518.1 - 0.059 13.5 0.0 0.1 12.7 0.0 1.4 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family RVT_3 PF13456.6 ETO13518.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Reverse transcriptase-like DUF863 PF05904.11 ETO13518.1 - 0.064 11.7 0.1 0.09 11.2 0.1 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) Lipoprotein_7 PF01540.16 ETO13518.1 - 0.29 10.4 4.5 0.054 12.8 0.6 1.6 2 0 0 2 2 2 0 Adhesin lipoprotein Ras PF00071.22 ETO13519.1 - 4.1e-29 101.3 0.0 1.3e-28 99.6 0.0 1.8 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO13519.1 - 9e-14 51.7 0.0 8.9e-13 48.5 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO13519.1 - 6.7e-06 25.7 0.0 1.1e-05 25.0 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO13519.1 - 0.00066 19.6 0.0 0.016 15.1 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO13519.1 - 0.016 15.3 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF3823 PF12866.7 ETO13519.1 - 0.026 14.8 0.0 0.62 10.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3823) N-terminal domain His_Phos_2 PF00328.22 ETO13520.1 - 1.1e-18 67.8 0.1 1.1e-18 67.8 0.1 1.4 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 2) PPIP5K2_N PF18086.1 ETO13520.1 - 7.4e-14 51.7 0.4 4.7e-13 49.1 0.2 2.4 1 1 1 2 2 2 1 Diphosphoinositol pentakisphosphate kinase 2 N-terminal domain RimK PF08443.11 ETO13520.1 - 0.053 13.1 0.0 0.53 9.9 0.0 2.2 2 0 0 2 2 2 0 RimK-like ATP-grasp domain Arg_tRNA_synt_N PF03485.16 ETO13520.1 - 0.11 13.1 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain LigB PF02900.18 ETO13521.1 - 3.2e-10 39.5 0.0 3.9e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Epimerase PF01370.21 ETO13522.1 - 1.9e-28 99.6 0.0 6.5e-28 97.8 0.0 1.7 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO13522.1 - 4e-21 75.8 0.0 1.1e-20 74.4 0.0 1.7 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Polysacc_synt_2 PF02719.15 ETO13522.1 - 6.7e-12 45.1 0.0 4.1e-11 42.6 0.0 2.2 2 1 0 2 2 2 1 Polysaccharide biosynthesis protein RmlD_sub_bind PF04321.17 ETO13522.1 - 3.9e-11 42.6 0.0 5.6e-11 42.1 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain 3Beta_HSD PF01073.19 ETO13522.1 - 2.2e-10 40.0 0.0 3.8e-10 39.2 0.0 1.4 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_4 PF07993.12 ETO13522.1 - 3.5e-08 32.9 0.2 5.3e-07 29.1 0.0 2.8 3 1 0 3 3 3 1 Male sterility protein NAD_binding_10 PF13460.6 ETO13522.1 - 7.2e-06 26.0 0.0 1.4e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding adh_short PF00106.25 ETO13522.1 - 0.0006 19.3 0.0 0.0019 17.7 0.0 1.9 2 0 0 2 2 2 1 short chain dehydrogenase KR PF08659.10 ETO13522.1 - 0.0033 17.4 0.2 0.0081 16.1 0.1 1.8 2 1 0 2 2 2 1 KR domain PRCC PF10253.9 ETO13523.1 - 2.3e-05 25.3 15.4 2.3e-05 25.3 15.4 4.3 1 1 2 3 3 3 1 Mitotic checkpoint regulator, MAD2B-interacting ATPase-cat_bd PF12156.8 ETO13524.1 - 3.3 8.5 7.9 0.15 12.8 0.9 2.6 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase CPSF100_C PF13299.6 ETO13524.1 - 4.2 7.5 10.2 4.6 7.4 1.0 3.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal PRIMA1 PF16101.5 ETO13525.1 - 0.16 12.0 3.9 0.33 11.0 3.9 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF724 PF05266.14 ETO13525.1 - 0.42 10.4 13.4 0.42 10.4 1.5 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF724) Tli4_C PF18426.1 ETO13525.1 - 0.54 10.6 3.4 0.17 12.2 0.3 1.8 2 0 0 2 2 2 0 Tle cognate immunity protein 4 C-terminal domain DUF5320 PF17253.2 ETO13525.1 - 5 8.3 5.1 32 5.7 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5320) APG6_N PF17675.1 ETO13525.1 - 6 7.4 17.4 4.1 8.0 11.2 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF745 PF05335.13 ETO13525.1 - 6.7 6.4 15.1 1.2 8.8 10.8 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF3450 PF11932.8 ETO13525.1 - 7.3 5.8 19.6 1.3 8.3 10.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) B56 PF01603.20 ETO13526.1 - 1.2e-32 113.4 0.8 1.2e-32 113.4 0.8 1.4 2 0 0 2 2 2 1 Protein phosphatase 2A regulatory B subunit (B56 family) Peptidase_C92 PF05708.12 ETO13527.1 - 0.00012 22.3 0.9 0.00061 19.9 0.8 2.0 1 1 0 1 1 1 1 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family DUF4834 PF16118.5 ETO13527.1 - 0.38 11.7 9.5 3.1 8.8 1.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EBP50_C PF09007.11 ETO13527.1 - 0.48 11.4 7.1 0.38 11.7 0.5 2.2 2 0 0 2 2 2 0 EBP50, C-terminal Mucin PF01456.17 ETO13527.1 - 0.51 10.3 22.0 0.95 9.4 22.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein CPSF100_C PF13299.6 ETO13527.1 - 2.9 8.0 11.2 6.9 6.8 2.0 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FYDLN_acid PF09538.10 ETO13527.1 - 3.8 8.2 21.1 2.3 8.9 10.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 ETO13527.1 - 3.9 7.9 12.7 5 7.5 2.1 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF3408 PF11888.8 ETO13527.1 - 5.5 7.1 13.7 1.3 9.2 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Tim54 PF11711.8 ETO13527.1 - 6.4 5.4 16.6 1.6 7.4 4.8 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 WD40 PF00400.32 ETO13528.1 - 0.059 14.3 1.4 3.2 8.8 0.1 3.7 4 0 0 4 4 4 0 WD domain, G-beta repeat Secretin_N_2 PF07655.13 ETO13528.1 - 0.29 11.7 15.1 0.54 10.8 15.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4834 PF16118.5 ETO13528.1 - 0.71 10.9 2.5 1.5 9.8 2.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) AAA_13 PF13166.6 ETO13529.1 - 2e-05 23.5 29.7 2e-05 23.5 29.7 4.9 3 1 1 5 5 5 2 AAA domain LMBR1 PF04791.16 ETO13529.1 - 0.00021 20.3 5.1 0.00021 20.3 5.1 4.6 1 1 3 4 4 2 1 LMBR1-like membrane protein TMF_DNA_bd PF12329.8 ETO13529.1 - 0.0011 18.9 14.2 0.0011 18.9 14.2 11.8 7 4 5 12 12 11 2 TATA element modulatory factor 1 DNA binding CENP-F_leu_zip PF10473.9 ETO13529.1 - 0.0012 18.9 142.9 0.097 12.7 23.2 8.0 2 2 1 6 6 6 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 ETO13529.1 - 0.0042 16.8 0.9 0.0042 16.8 0.9 12.8 8 4 7 15 15 14 4 Septum formation initiator ATG16 PF08614.11 ETO13529.1 - 0.0049 17.1 22.4 0.0049 17.1 22.4 7.4 3 2 5 8 8 8 3 Autophagy protein 16 (ATG16) SCO1-SenC PF02630.14 ETO13529.1 - 0.23 11.4 1.9 26 4.7 0.0 4.1 3 1 0 3 3 3 0 SCO1/SenC DUF948 PF06103.11 ETO13529.1 - 0.57 10.5 0.0 0.57 10.5 0.0 8.0 6 2 2 8 8 8 0 Bacterial protein of unknown function (DUF948) Rol_Rep_N PF18106.1 ETO13529.1 - 0.89 9.9 4.9 26 5.2 0.4 3.9 3 1 0 3 3 3 0 Rolling Circle replication initiation protein N-terminal domain CEP63 PF17045.5 ETO13529.1 - 1.3 8.9 119.2 0.01 15.8 31.6 5.4 2 1 3 5 5 5 0 Centrosomal protein of 63 kDa MtrB PF05440.12 ETO13529.1 - 1.4 9.4 5.6 2.2 8.8 0.2 3.9 3 1 1 4 4 4 0 Tetrahydromethanopterin S-methyltransferase subunit B TPR_MLP1_2 PF07926.12 ETO13532.1 - 7.1e-06 26.1 38.0 0.0058 16.7 17.4 2.3 2 1 0 2 2 2 2 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO13532.1 - 0.0015 18.0 20.8 0.0059 16.0 18.0 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF4407) Spc7 PF08317.11 ETO13532.1 - 0.0015 17.5 31.3 0.01 14.8 31.6 1.8 1 1 0 1 1 1 1 Spc7 kinetochore protein GAS PF13851.6 ETO13532.1 - 0.0022 17.4 19.8 0.0022 17.4 19.8 2.6 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding DUF3450 PF11932.8 ETO13532.1 - 0.0041 16.5 32.3 0.08 12.2 13.8 2.6 1 1 2 3 3 3 2 Protein of unknown function (DUF3450) HALZ PF02183.18 ETO13532.1 - 0.011 16.0 16.6 0.024 14.9 0.5 5.1 4 3 2 6 6 4 0 Homeobox associated leucine zipper Jnk-SapK_ap_N PF09744.9 ETO13532.1 - 0.012 15.9 37.4 0.035 14.3 3.5 3.0 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Filament PF00038.21 ETO13532.1 - 0.013 15.1 33.0 0.19 11.3 16.5 2.0 1 1 0 2 2 2 0 Intermediate filament protein DUF4988 PF16378.5 ETO13532.1 - 0.015 14.9 4.7 0.69 9.5 0.6 2.6 3 0 0 3 3 2 0 Domain of unknown function LPP PF04728.13 ETO13532.1 - 0.024 15.0 12.4 3.1 8.3 1.3 4.4 2 1 2 4 4 4 0 Lipoprotein leucine-zipper Seryl_tRNA_N PF02403.22 ETO13532.1 - 0.031 14.5 28.2 1.4 9.1 8.3 3.1 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain T3SSipB PF16535.5 ETO13532.1 - 0.041 14.4 18.7 0.042 14.3 0.9 2.3 1 1 1 2 2 2 0 Type III cell invasion protein SipB NPV_P10 PF05531.12 ETO13532.1 - 0.058 13.9 9.2 0.99 9.9 0.2 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein WXG100 PF06013.12 ETO13532.1 - 0.091 13.0 0.4 0.091 13.0 0.4 3.7 3 1 0 3 3 3 0 Proteins of 100 residues with WXG ABC2_membrane_3 PF12698.7 ETO13532.1 - 0.11 11.6 1.8 0.13 11.3 1.8 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein DUF1461 PF07314.11 ETO13532.1 - 0.13 12.2 7.4 0.091 12.7 6.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) GIT_CC PF16559.5 ETO13532.1 - 0.36 10.7 16.5 0.45 10.4 4.9 3.1 2 2 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor CLZ PF16526.5 ETO13532.1 - 0.38 11.1 17.2 0.72 10.3 3.6 3.0 2 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1664 PF07889.12 ETO13532.1 - 0.46 10.5 19.8 1.4 9.0 3.8 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF3584 PF12128.8 ETO13532.1 - 0.64 7.5 28.4 0.96 6.9 28.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF5320 PF17253.2 ETO13532.1 - 0.86 10.7 18.4 2.5 9.2 0.9 3.7 2 2 1 3 3 3 0 Family of unknown function (DUF5320) DUF948 PF06103.11 ETO13532.1 - 0.92 9.8 11.5 0.28 11.5 0.5 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CALCOCO1 PF07888.11 ETO13532.1 - 1.1 8.0 32.9 2.7 6.8 33.0 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like FlaC_arch PF05377.11 ETO13532.1 - 1.6 9.2 16.5 0.51 10.8 1.0 4.0 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Fmp27_WPPW PF10359.9 ETO13532.1 - 1.7 7.4 30.5 3.1 6.6 18.8 2.0 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Golgin_A5 PF09787.9 ETO13532.1 - 1.7 8.0 34.3 12 5.2 10.6 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 ING PF12998.7 ETO13532.1 - 2.1 9.0 20.8 0.17 12.5 1.4 3.1 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding BicD PF09730.9 ETO13532.1 - 2.2 6.6 28.7 0.079 11.4 8.4 2.3 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D TMF_TATA_bd PF12325.8 ETO13532.1 - 2.4 8.4 33.0 1.1 9.5 7.6 3.3 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Spc24 PF08286.11 ETO13532.1 - 2.6 8.3 33.7 0.18 12.0 4.7 4.0 1 1 3 4 4 4 0 Spc24 subunit of Ndc80 DUF2968 PF11180.8 ETO13532.1 - 2.6 7.7 26.9 0.29 10.7 8.2 2.4 3 0 0 3 3 2 0 Protein of unknown function (DUF2968) SOGA PF11365.8 ETO13532.1 - 2.6 9.2 25.8 0.18 12.9 8.2 2.9 2 1 1 3 3 3 0 Protein SOGA BLOC1_2 PF10046.9 ETO13532.1 - 2.6 8.4 28.2 4 7.8 5.9 3.3 1 1 2 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 APG6_N PF17675.1 ETO13532.1 - 2.7 8.5 39.3 6.8 7.2 23.2 2.7 1 1 2 3 3 3 0 Apg6 coiled-coil region HOOK PF05622.12 ETO13532.1 - 3.4 5.7 32.6 1.8 6.6 20.8 1.9 1 1 0 1 1 1 0 HOOK protein IFT57 PF10498.9 ETO13532.1 - 3.6 6.5 32.1 11 4.8 18.0 2.5 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 HrpB7 PF09486.10 ETO13532.1 - 3.6 7.9 16.9 11 6.4 13.2 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) FUSC PF04632.12 ETO13532.1 - 4 5.8 6.8 7.8 4.9 6.8 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family UPF0242 PF06785.11 ETO13532.1 - 4.1 7.5 39.9 4.6 7.3 13.4 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Mod_r PF07200.13 ETO13532.1 - 4.3 7.4 36.3 3.2 7.9 2.9 3.2 1 1 2 3 3 3 0 Modifier of rudimentary (Mod(r)) protein CENP-F_leu_zip PF10473.9 ETO13532.1 - 4.3 7.4 34.4 7.4 6.6 17.4 2.7 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MAD PF05557.13 ETO13532.1 - 4.5 5.5 35.9 1.1 7.6 8.6 1.9 1 1 1 2 2 2 0 Mitotic checkpoint protein JAKMIP_CC3 PF16034.5 ETO13532.1 - 4.6 7.1 30.2 0.12 12.3 10.0 2.4 1 1 1 2 2 2 0 JAKMIP CC3 domain DUF2730 PF10805.8 ETO13532.1 - 6.4 6.9 13.6 0.87 9.7 3.5 3.0 1 1 1 3 3 3 0 Protein of unknown function (DUF2730) DUF848 PF05852.11 ETO13532.1 - 6.9 6.8 22.8 2.4 8.3 6.3 2.1 1 1 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Lectin_N PF03954.14 ETO13532.1 - 8.4 6.2 17.7 2.7 7.7 0.9 3.0 1 1 2 3 3 3 0 Hepatic lectin, N-terminal domain FlxA PF14282.6 ETO13532.1 - 8.5 6.4 34.9 0.34 10.9 8.2 3.0 1 1 2 3 3 3 0 FlxA-like protein Fez1 PF06818.15 ETO13532.1 - 8.5 6.8 32.3 50 4.3 32.5 2.0 1 1 0 1 1 1 0 Fez1 ADIP PF11559.8 ETO13532.1 - 8.7 6.4 36.9 1.4 9.0 8.8 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding P53_C PF11619.8 ETO13535.1 - 0.078 13.1 0.3 0.17 12.0 0.3 1.5 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain zf-Di19 PF05605.12 ETO13536.1 - 0.0067 16.7 0.7 0.0067 16.7 0.7 3.4 2 1 0 2 2 2 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_11 PF16622.5 ETO13536.1 - 0.016 15.0 1.4 0.053 13.3 1.4 1.9 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2_6 PF13912.6 ETO13536.1 - 0.033 14.2 0.3 0.12 12.4 0.3 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO13536.1 - 0.049 14.1 1.8 0.049 14.1 1.8 5.2 6 0 0 6 6 6 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 ETO13536.1 - 2.1 8.2 15.3 0.54 10.1 0.7 3.5 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-H2C2_2 PF13465.6 ETO13536.1 - 10 6.8 19.3 0.22 12.0 2.8 4.0 4 0 0 4 4 4 0 Zinc-finger double domain His_Phos_1 PF00300.22 ETO13537.1 - 1.2e-07 31.7 0.5 0.02 14.6 0.2 2.5 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) Ctr PF04145.15 ETO13537.1 - 0.26 11.9 4.2 0.98 10.0 4.1 2.0 1 1 0 1 1 1 0 Ctr copper transporter family YMF19 PF02326.15 ETO13537.1 - 4 8.3 7.5 0.69 10.7 2.6 2.3 3 0 0 3 3 3 0 Plant ATP synthase F0 FAD-oxidase_C PF02913.19 ETO13538.1 - 3e-45 154.8 0.0 4e-45 154.4 0.0 1.2 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ETO13538.1 - 1.7e-30 105.6 0.0 7.9e-26 90.4 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain PLDc_2 PF13091.6 ETO13539.1 - 3.6e-37 127.2 0.0 1.2e-22 80.3 0.0 2.7 2 0 0 2 2 2 2 PLD-like domain PLDc PF00614.22 ETO13539.1 - 3.1e-09 36.6 4.0 0.00043 20.3 0.1 2.6 2 0 0 2 2 2 2 Phospholipase D Active site motif DUF262 PF03235.14 ETO13539.1 - 8.5 6.5 9.5 32 4.6 7.4 2.6 2 1 0 2 2 2 0 Protein of unknown function DUF262 WD40 PF00400.32 ETO13541.1 - 2e-26 91.7 23.7 6e-06 26.9 0.5 5.7 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13541.1 - 3.2e-08 33.8 0.4 0.00082 19.6 0.1 3.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO13541.1 - 0.011 15.0 0.5 2.3 7.5 0.2 2.8 2 1 0 3 3 3 0 WD40-like domain PEX-2N PF09263.10 ETO13541.1 - 0.066 13.5 1.6 0.091 13.1 0.4 1.9 2 0 0 2 2 2 0 Peroxisome biogenesis factor 1, N-terminal F-box-like PF12937.7 ETO13542.1 - 7.6e-07 28.9 0.4 1.3e-06 28.2 0.4 1.4 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO13542.1 - 1.6e-06 27.8 0.7 5e-06 26.2 0.1 2.0 2 0 0 2 2 2 1 F-box domain WD40 PF00400.32 ETO13542.1 - 0.009 16.8 0.0 0.027 15.3 0.0 1.9 1 0 0 1 1 1 1 WD domain, G-beta repeat Gag_spuma PF03276.14 ETO13542.1 - 2.2 6.6 9.5 2.9 6.2 9.5 1.1 1 0 0 1 1 1 0 Spumavirus gag protein zf-RING_2 PF13639.6 ETO13543.1 - 4.4e-13 49.3 4.0 8e-13 48.5 4.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO13543.1 - 4.5e-11 42.4 4.8 8e-11 41.6 4.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO13543.1 - 1.4e-09 37.5 1.1 1.4e-09 37.5 1.1 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 ETO13543.1 - 3.1e-08 33.3 4.0 6.3e-08 32.4 4.0 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO13543.1 - 4e-08 33.4 8.6 9.7e-08 32.2 8.6 1.9 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETO13543.1 - 4.2e-06 26.7 1.1 2.5e-05 24.2 1.1 2.1 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO13543.1 - 4.6e-06 26.4 3.5 4.6e-06 26.4 3.5 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO13543.1 - 1.6e-05 24.7 2.9 1.6e-05 24.7 2.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ETO13543.1 - 1.8e-05 24.7 1.0 3.3e-05 23.9 1.0 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO13543.1 - 0.00023 21.0 3.2 0.00023 21.0 3.2 1.8 2 1 0 2 2 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ETO13543.1 - 0.0012 18.4 4.1 0.0012 18.4 4.1 2.6 2 1 1 3 3 3 1 Zinc-ribbon, C4HC2 type FANCL_C PF11793.8 ETO13543.1 - 0.0085 16.2 0.9 0.0085 16.2 0.9 2.6 2 1 1 3 3 2 1 FANCL C-terminal domain zf-RING_4 PF14570.6 ETO13543.1 - 0.024 14.4 3.9 0.056 13.3 3.9 1.7 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_10 PF16685.5 ETO13543.1 - 0.028 14.6 2.3 0.028 14.6 2.3 1.6 2 0 0 2 2 2 0 zinc RING finger of MSL2 zinc_ribbon_16 PF17034.5 ETO13543.1 - 0.053 13.7 5.8 0.46 10.7 5.8 2.3 1 1 0 1 1 1 0 Zinc-ribbon like family zf-RING-like PF08746.11 ETO13543.1 - 0.054 13.8 2.8 0.054 13.8 2.8 1.7 2 0 0 2 2 2 0 RING-like domain zf-C3H2C3 PF17122.5 ETO13543.1 - 0.5 10.5 5.7 0.17 12.0 2.5 1.9 2 1 0 2 2 1 0 Zinc-finger Prok-RING_1 PF14446.6 ETO13543.1 - 0.79 9.7 12.2 0.23 11.4 1.6 2.9 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 PHD PF00628.29 ETO13543.1 - 0.9 9.5 9.9 0.25 11.3 4.5 2.5 2 1 0 2 2 2 0 PHD-finger RINGv PF12906.7 ETO13543.1 - 2.3 8.4 12.2 1.3 9.2 5.1 2.6 1 1 1 2 2 2 0 RING-variant domain VMA21 PF09446.10 ETO13544.1 - 2e-12 47.0 1.6 2.7e-12 46.6 1.6 1.2 1 0 0 1 1 1 1 VMA21-like domain Cytochrom_B558a PF05038.13 ETO13544.1 - 0.15 11.6 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Cytochrome Cytochrome b558 alpha-subunit ARA70 PF12489.8 ETO13544.1 - 0.15 12.2 1.6 0.6 10.3 0.3 2.0 2 0 0 2 2 2 0 Nuclear coactivator Collectrin PF16959.5 ETO13545.1 - 0.00024 20.9 0.0 0.00054 19.8 0.0 1.6 1 0 0 1 1 1 1 Renal amino acid transporter ubiquitin PF00240.23 ETO13545.1 - 0.0029 17.3 0.7 0.0053 16.5 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family Ubiquitin_5 PF18037.1 ETO13545.1 - 0.006 16.9 0.0 0.037 14.4 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-like domain IBR PF01485.21 ETO13545.1 - 0.068 13.4 1.1 0.068 13.4 1.1 2.4 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain FSAP_sig_propep PF03032.15 ETO13545.1 - 0.14 12.2 5.1 1.7 8.7 3.7 2.7 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide Kelch_1 PF01344.25 ETO13546.1 - 0.094 12.3 0.3 1 9.0 0.1 2.7 3 0 0 3 3 3 0 Kelch motif Anoctamin PF04547.12 ETO13547.1 - 9.4e-27 93.9 0.5 1.4e-26 93.4 0.5 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel PgaD PF13994.6 ETO13547.1 - 0.078 13.0 4.8 0.039 14.0 1.4 2.0 1 1 1 2 2 2 0 PgaD-like protein Saf_2TM PF18303.1 ETO13547.1 - 0.19 11.3 1.0 0.26 10.9 0.1 1.6 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain HXXEE PF13787.6 ETO13547.1 - 0.29 11.9 10.5 2 9.3 7.3 2.5 2 1 0 2 2 2 0 Protein of unknown function with HXXEE motif Anoctamin PF04547.12 ETO13548.1 - 4e-41 141.3 13.0 4.4e-41 141.2 13.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Crystall_2 PF09076.10 ETO13548.1 - 0.0049 16.7 0.0 0.0093 15.8 0.0 1.5 1 0 0 1 1 1 1 Beta/Gamma crystallin DUF3963 PF13124.6 ETO13548.1 - 1.7 8.7 10.0 0.071 13.1 2.4 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3963) VKOR PF07884.14 ETO13548.1 - 7.8 6.7 11.8 9.2 6.5 1.2 2.1 2 0 0 2 2 2 0 Vitamin K epoxide reductase family Anoctamin PF04547.12 ETO13549.1 - 1.7e-07 30.5 11.9 2.5e-07 29.9 9.3 2.0 2 0 0 2 2 2 1 Calcium-activated chloride channel zf-RRPl_C4 PF17026.5 ETO13549.1 - 0.058 13.5 2.6 0.07 13.2 0.2 2.1 2 0 0 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type Enkurin PF13864.6 ETO13549.1 - 0.069 13.6 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 Calmodulin-binding UCH PF00443.29 ETO13550.1 - 9.8e-31 107.2 0.0 4e-30 105.2 0.0 1.8 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO13550.1 - 6.6e-06 25.9 0.1 1.1e-05 25.2 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TFIIA PF03153.13 ETO13551.1 - 0.0059 16.7 18.7 0.0066 16.5 18.7 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2868 PF11067.8 ETO13551.1 - 0.34 10.4 5.3 0.36 10.3 5.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) TonB_N PF16031.5 ETO13551.1 - 2.6 8.6 30.0 4.3 7.8 29.8 1.5 1 1 0 1 1 1 0 TonB polyproline region Trypan_PARP PF05887.11 ETO13551.1 - 3.3 7.7 19.1 3.1 7.8 17.6 1.8 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF5551 PF17705.1 ETO13552.1 - 0.099 12.3 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5551) Cnd2 PF05786.14 ETO13553.1 - 0.019 13.7 9.4 0.024 13.3 9.4 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 FAM176 PF14851.6 ETO13553.1 - 1.6 8.4 7.6 2.4 7.8 7.6 1.3 1 0 0 1 1 1 0 FAM176 family Presenilin PF01080.17 ETO13553.1 - 2.2 7.0 7.1 2.2 7.0 7.1 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO13553.1 - 2.2 7.0 11.3 2.4 6.9 11.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 ETO13553.1 - 4.7 5.4 10.7 4.6 5.4 10.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO13553.1 - 5.8 6.6 6.2 6.7 6.4 6.2 1.3 1 0 0 1 1 1 0 Connexin FancD2 PF14631.6 ETO13553.1 - 7.1 3.9 7.9 7 3.9 7.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Orthopox_F7 PF05813.12 ETO13553.1 - 9.8 6.4 8.2 8.3 6.6 4.2 2.2 1 1 1 2 2 2 0 Orthopoxvirus F7 protein Cupin_8 PF13621.6 ETO13555.1 - 7.8e-22 78.2 3.4 1.2e-21 77.6 3.4 1.3 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ETO13555.1 - 0.0054 17.1 2.1 0.26 11.7 0.1 2.6 2 0 0 2 2 2 2 JmjC domain, hydroxylase Frigida PF07899.11 ETO13557.1 - 0.014 14.7 0.2 0.021 14.1 0.2 1.3 1 0 0 1 1 1 0 Frigida-like protein GatB_Yqey PF02637.18 ETO13557.1 - 0.1 12.5 1.4 2.5 8.0 0.2 2.5 1 1 1 2 2 2 0 GatB domain DUF2255 PF10012.9 ETO13557.1 - 0.11 12.7 0.1 0.17 12.0 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2255) Apc15p PF05841.11 ETO13558.1 - 0.03 15.1 2.5 0.038 14.8 2.5 1.1 1 0 0 1 1 1 0 Apc15p protein DUF2957 PF11170.8 ETO13558.1 - 0.11 11.3 0.0 0.12 11.2 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2957) Gti1_Pac2 PF09729.9 ETO13558.1 - 0.16 12.0 2.7 0.19 11.8 2.7 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF724 PF05266.14 ETO13558.1 - 0.2 11.4 6.8 0.24 11.2 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) HECT PF00632.25 ETO13559.1 - 4.3e-92 308.9 0.2 8.5e-92 307.9 0.2 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Secretin_N_2 PF07655.13 ETO13561.1 - 1.7 9.2 12.6 0.24 12.0 7.9 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain Menin PF05053.13 ETO13563.1 - 3 6.1 13.7 4.9 5.4 13.4 1.6 1 1 0 1 1 1 0 Menin GCD14 PF08704.10 ETO13564.1 - 2.4 7.8 7.9 4.4 6.9 7.9 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit SBDS_C PF09377.10 ETO13565.1 - 0.11 12.5 4.0 0.14 12.2 3.6 1.3 1 1 0 1 1 1 0 SBDS protein C-terminal domain Sugar_tr PF00083.24 ETO13565.1 - 0.19 10.6 1.5 0.28 10.0 1.5 1.2 1 0 0 1 1 1 0 Sugar (and other) transporter Atrophin-1 PF03154.15 ETO13565.1 - 1.2 7.4 3.2 1.2 7.3 3.2 1.0 1 0 0 1 1 1 0 Atrophin-1 family TPR_2 PF07719.17 ETO13566.1 - 8.8e-09 34.8 9.3 0.014 15.4 0.2 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13566.1 - 1e-06 28.5 23.4 0.055 13.7 0.0 6.1 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13566.1 - 1.6e-06 27.7 7.6 0.057 13.3 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO13566.1 - 0.00034 20.8 11.4 1.9 8.8 0.1 4.8 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13566.1 - 0.00078 20.1 5.5 1.1 10.3 0.0 4.5 5 0 0 5 5 5 2 Tetratricopeptide repeat Med3 PF11593.8 ETO13566.1 - 0.0039 16.4 3.3 0.0059 15.9 3.3 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal TPR_7 PF13176.6 ETO13566.1 - 0.0087 16.0 1.0 4.6 7.5 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO13566.1 - 0.13 12.2 1.8 21 5.1 0.2 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13567.1 - 1.1e-11 43.9 9.2 0.024 14.7 0.0 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO13567.1 - 4.5e-11 42.9 3.0 0.012 15.9 0.0 4.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO13567.1 - 1.4e-08 34.5 2.6 0.00059 20.0 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO13567.1 - 4.4e-08 33.5 0.1 0.00097 19.6 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO13567.1 - 8e-08 31.9 2.0 0.053 13.4 0.0 4.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13567.1 - 5.4e-07 29.2 6.6 0.08 12.8 0.1 4.9 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13567.1 - 0.00083 19.4 18.4 0.39 11.1 0.4 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13567.1 - 0.0014 19.2 0.0 22 6.2 0.1 3.6 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO13567.1 - 0.0082 16.8 0.0 17 6.1 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO13567.1 - 0.059 13.4 0.1 13 6.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat AAA PF00004.29 ETO13568.1 - 2.4e-41 141.2 0.0 3.7e-41 140.6 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO13568.1 - 4.3e-07 30.5 0.1 6.3e-05 23.4 0.0 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ETO13568.1 - 4.6e-07 30.1 0.0 2.6e-06 27.6 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ETO13568.1 - 2.7e-05 24.0 0.0 7.4e-05 22.6 0.0 1.8 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO13568.1 - 3.7e-05 23.8 0.0 0.00018 21.5 0.0 2.2 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ETO13568.1 - 8e-05 22.8 0.0 0.00024 21.3 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO13568.1 - 8.7e-05 22.8 0.1 0.0011 19.3 0.1 2.2 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETO13568.1 - 0.00011 22.0 0.0 0.00031 20.5 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein TIP49 PF06068.13 ETO13568.1 - 0.00072 18.9 0.0 0.00099 18.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RNA_helicase PF00910.22 ETO13568.1 - 0.001 19.4 0.0 0.0027 18.1 0.0 1.9 1 1 0 1 1 1 1 RNA helicase AAA_14 PF13173.6 ETO13568.1 - 0.0022 18.0 0.0 0.0058 16.7 0.0 1.7 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETO13568.1 - 0.0024 17.4 0.0 0.0046 16.5 0.0 1.4 1 1 0 1 1 1 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 ETO13568.1 - 0.0025 17.2 0.0 0.0046 16.4 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ETO13568.1 - 0.0047 16.9 0.0 0.057 13.3 0.0 2.2 1 1 0 2 2 2 1 ATPase domain predominantly from Archaea TsaE PF02367.17 ETO13568.1 - 0.0048 16.9 0.0 0.0073 16.3 0.0 1.3 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETO13568.1 - 0.0048 17.4 0.0 0.0073 16.8 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_25 PF13481.6 ETO13568.1 - 0.0053 16.3 0.2 0.26 10.9 0.1 2.1 1 1 0 2 2 2 1 AAA domain Rad17 PF03215.15 ETO13568.1 - 0.0093 15.9 0.1 0.14 12.1 0.1 2.0 1 1 1 2 2 2 1 Rad17 P-loop domain AAA_28 PF13521.6 ETO13568.1 - 0.01 16.1 0.0 0.029 14.6 0.0 1.8 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO13568.1 - 0.014 15.3 0.1 0.12 12.3 0.1 2.2 2 0 0 2 2 2 0 NACHT domain AAA_18 PF13238.6 ETO13568.1 - 0.016 15.7 0.0 0.03 14.9 0.0 1.7 1 1 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO13568.1 - 0.022 14.4 0.0 0.046 13.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain DUF815 PF05673.13 ETO13568.1 - 0.028 13.6 0.0 0.043 13.0 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 ETO13568.1 - 0.03 13.5 0.0 0.058 12.6 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain AAA_24 PF13479.6 ETO13568.1 - 0.043 13.5 0.0 0.066 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ETO13568.1 - 0.051 14.0 0.1 0.2 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain Sigma54_activ_2 PF14532.6 ETO13568.1 - 0.089 12.9 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain PhoH PF02562.16 ETO13568.1 - 0.091 12.2 0.1 0.16 11.4 0.1 1.4 1 1 0 1 1 1 0 PhoH-like protein ATPase PF06745.13 ETO13568.1 - 0.11 11.8 0.2 0.44 9.9 0.0 2.0 2 1 1 3 3 3 0 KaiC AAA_3 PF07726.11 ETO13568.1 - 0.13 12.1 0.0 0.23 11.3 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Parvo_NS1 PF01057.17 ETO13568.1 - 0.24 10.4 0.0 0.38 9.8 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 BCAS3 PF12490.8 ETO13569.1 - 0.00035 20.2 0.7 0.00035 20.2 0.7 1.8 2 0 0 2 2 2 1 Breast carcinoma amplified sequence 3 Spindle_Spc25 PF08234.12 ETO13569.1 - 0.023 14.9 0.3 0.075 13.3 0.1 1.9 2 0 0 2 2 2 0 Chromosome segregation protein Spc25 SRP-alpha_N PF04086.13 ETO13570.1 - 1.4 8.8 34.9 1.7 8.5 34.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Cation_ATPase PF13246.6 ETO13571.1 - 7.9e-17 61.1 0.0 9e-17 60.9 0.0 1.1 1 0 0 1 1 1 1 Cation transport ATPase (P-type) TPR_11 PF13414.6 ETO13572.1 - 9e-05 22.1 6.1 0.0008 19.0 0.5 3.3 2 1 1 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO13572.1 - 0.00015 21.9 5.4 0.014 15.7 0.5 3.1 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13572.1 - 0.0034 17.4 3.0 1 9.6 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13572.1 - 0.072 12.9 7.0 6.9 6.7 0.1 4.4 3 1 0 3 3 3 0 Tetratricopeptide repeat EF-hand_5 PF13202.6 ETO13573.1 - 3.4e-05 23.1 0.6 7.6e-05 22.0 0.6 1.6 1 0 0 1 1 1 1 EF hand EF-hand_1 PF00036.32 ETO13573.1 - 0.00017 20.9 0.7 0.00057 19.2 0.7 2.0 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO13573.1 - 0.00039 20.8 0.4 0.00039 20.8 0.4 2.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO13573.1 - 0.0018 18.1 0.2 0.0074 16.1 0.2 2.1 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 ETO13573.1 - 0.018 14.9 0.9 0.065 13.1 0.2 2.2 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_13 PF17958.1 ETO13574.1 - 1.1e-19 70.0 0.2 5.1e-19 67.9 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ETO13574.1 - 0.00028 21.3 0.0 0.87 10.1 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain pair Vps39_1 PF10366.9 ETO13574.1 - 0.08 13.2 0.6 3 8.2 0.1 2.9 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 WD40 PF00400.32 ETO13575.1 - 0.00047 20.9 0.2 0.00047 20.9 0.2 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat NST1 PF13945.6 ETO13575.1 - 0.021 15.0 5.2 0.021 15.0 5.2 3.1 3 0 0 3 3 3 0 Salt tolerance down-regulator RPN2_C PF18004.1 ETO13575.1 - 0.18 11.7 14.9 0.4 10.6 1.1 3.2 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain ATXN-1_C PF12547.8 ETO13576.1 - 0.36 11.2 0.2 0.36 11.2 0.2 4.9 2 2 5 7 7 7 0 Capicua transcriptional repressor modulator Rsc14 PF08586.10 ETO13577.1 - 7.8 7.4 11.3 0.3 11.9 1.7 2.9 2 1 2 4 4 4 0 RSC complex, Rsc14/Ldb7 subunit tRNA_m1G_MT PF01746.21 ETO13578.1 - 5.7e-08 32.7 0.0 7.6e-08 32.3 0.0 1.3 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase NGP1NT PF08153.12 ETO13579.1 - 8.4e-45 152.1 2.2 1.8e-44 151.1 2.2 1.5 1 0 0 1 1 1 1 NGP1NT (NUC091) domain MSV199 PF10553.9 ETO13579.1 - 0.066 13.5 1.0 1.3 9.3 0.2 2.4 2 0 0 2 2 2 0 MSV199 domain MMR_HSR1 PF01926.23 ETO13580.1 - 5.9e-15 55.4 0.0 1.3e-14 54.2 0.0 1.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO13580.1 - 9.2e-05 22.0 0.0 0.00017 21.2 0.0 1.4 1 0 0 1 1 1 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ETO13580.1 - 0.00021 21.4 2.2 0.004 17.2 0.2 3.0 2 1 1 3 3 3 1 Dynamin family MeaB PF03308.16 ETO13580.1 - 0.052 12.5 0.0 0.08 11.9 0.0 1.2 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB ABC_tran PF00005.27 ETO13580.1 - 0.059 13.9 0.2 0.44 11.0 0.0 2.4 2 1 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 ETO13580.1 - 0.1 12.5 0.0 0.24 11.3 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Ank_4 PF13637.6 ETO13581.1 - 2.7e-05 24.6 4.2 0.44 11.2 0.2 4.1 3 2 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO13581.1 - 0.00011 22.4 0.7 0.72 10.2 0.1 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) DUF4508 PF14969.6 ETO13581.1 - 0.0011 19.2 0.1 0.0023 18.2 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4508) CmcI PF04989.12 ETO13581.1 - 0.09 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 Cephalosporin hydroxylase HR1 PF02185.16 ETO13582.1 - 0.036 14.2 1.2 0.082 13.0 1.2 1.6 1 0 0 1 1 1 0 Hr1 repeat DUF4407 PF14362.6 ETO13582.1 - 0.81 9.0 3.2 1.1 8.5 3.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XRCC4 PF06632.12 ETO13582.1 - 3.4 6.4 10.6 6 5.6 10.6 1.4 1 1 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 zf-CCCH PF00642.24 ETO13583.1 - 6.2e-06 26.0 16.7 5.4e-05 23.0 2.4 4.8 3 1 1 4 4 4 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF848 PF05852.11 ETO13583.1 - 0.0096 16.0 1.4 0.018 15.2 1.4 1.5 1 0 0 1 1 1 1 Gammaherpesvirus protein of unknown function (DUF848) TMCO5 PF14992.6 ETO13583.1 - 0.15 11.6 4.2 0.27 10.8 4.2 1.3 1 0 0 1 1 1 0 TMCO5 family Raco_middle PF17651.1 ETO13583.1 - 0.19 11.4 0.3 0.33 10.6 0.3 1.3 1 0 0 1 1 1 0 RACo middle region TPR_11 PF13414.6 ETO13584.1 - 6.5e-13 48.1 4.3 4.9e-06 26.1 0.4 4.3 2 2 2 4 4 4 3 TPR repeat TPR_2 PF07719.17 ETO13584.1 - 2.4e-09 36.6 5.3 0.021 14.9 0.7 5.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO13584.1 - 1.2e-07 31.6 0.2 0.076 13.4 0.2 3.8 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13584.1 - 5.6e-07 29.1 12.8 0.0027 17.4 1.0 5.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13584.1 - 1.1e-06 28.3 10.7 0.11 12.7 0.2 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO13584.1 - 6.1e-06 26.4 0.4 0.43 10.9 0.0 3.6 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO13584.1 - 0.0014 19.0 1.3 18 6.0 0.0 4.3 3 2 1 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO13584.1 - 0.0043 17.0 0.8 2.3 8.4 0.2 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13584.1 - 0.0073 17.0 0.2 38 5.5 0.0 3.9 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 ETO13584.1 - 0.014 14.6 0.0 2.2 7.4 0.0 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO13584.1 - 0.029 14.5 0.0 1.9 8.7 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO13584.1 - 0.12 13.1 0.2 40 5.0 0.1 2.9 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF713 PF05218.14 ETO13585.1 - 0.044 13.5 0.5 0.068 12.9 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF713) TTD PF12148.8 ETO13585.1 - 0.072 13.0 0.3 0.11 12.4 0.3 1.2 1 0 0 1 1 1 0 Tandem tudor domain within UHRF1 Viral_Beta_CD PF04530.12 ETO13586.1 - 0.049 13.9 2.1 0.053 13.8 0.8 1.8 2 1 0 2 2 2 0 Viral Beta C/D like family PhyH PF05721.13 ETO13587.1 - 0.0006 20.1 0.0 0.0042 17.4 0.0 2.2 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ETO13587.1 - 0.01 14.6 0.0 0.041 12.7 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Cloacin_immun PF03513.14 ETO13588.1 - 0.015 15.7 2.9 0.035 14.4 0.3 2.1 1 1 1 2 2 2 0 Cloacin immunity protein YL1 PF05764.13 ETO13589.1 - 0.0031 17.7 11.3 0.0041 17.3 11.3 1.2 1 1 0 1 1 1 1 YL1 nuclear protein Fmp27 PF10344.9 ETO13589.1 - 0.0078 14.4 0.4 0.01 14.0 0.4 1.0 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 FmiP_Thoc5 PF09766.9 ETO13589.1 - 0.012 14.9 2.6 0.02 14.2 2.6 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 CDC45 PF02724.14 ETO13589.1 - 0.035 12.4 6.7 0.039 12.3 6.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_2 PF00703.21 ETO13589.1 - 0.067 13.9 2.3 0.12 13.1 2.3 1.4 1 0 0 1 1 1 0 Glycosyl hydrolases family 2 Strabismus PF06638.11 ETO13589.1 - 0.17 10.5 1.5 0.21 10.2 1.5 1.1 1 0 0 1 1 1 0 Strabismus protein DDHD PF02862.17 ETO13589.1 - 0.44 10.7 4.9 0.07 13.3 1.3 1.4 2 0 0 2 2 2 0 DDHD domain Presenilin PF01080.17 ETO13589.1 - 0.73 8.5 2.9 0.8 8.4 2.9 1.2 1 0 0 1 1 1 0 Presenilin TRAP_alpha PF03896.16 ETO13589.1 - 0.87 8.7 9.2 1.5 8.0 9.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO13589.1 - 2 6.4 12.4 2.7 6.0 12.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ETO13589.1 - 2.8 7.6 13.4 1.6 8.3 11.0 1.7 2 0 0 2 2 2 0 FAM176 family Sec62 PF03839.16 ETO13589.1 - 2.8 7.4 4.9 0.46 10.0 1.7 1.3 2 0 0 2 2 2 0 Translocation protein Sec62 GOLD_2 PF13897.6 ETO13589.1 - 3.4 8.2 6.9 14 6.2 6.1 1.9 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking DUF2722 PF10846.8 ETO13589.1 - 4.1 6.2 8.4 3.2 6.6 4.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF4746 PF15928.5 ETO13589.1 - 9.2 5.6 13.7 16 4.8 13.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RPA43_OB PF17875.1 ETO13589.1 - 9.4 6.9 9.2 9.4 6.9 4.3 2.2 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Ank_2 PF12796.7 ETO13590.1 - 9.7e-05 22.9 0.1 0.00037 21.0 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) DUF2457 PF10446.9 ETO13590.1 - 0.0049 16.1 22.7 0.0049 16.1 22.7 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2457) Ank_3 PF13606.6 ETO13590.1 - 0.015 15.8 0.6 0.34 11.6 0.1 2.9 2 0 0 2 2 2 0 Ankyrin repeat Flavodoxin_4 PF12682.7 ETO13590.1 - 0.17 11.6 0.0 0.36 10.5 0.0 1.5 1 0 0 1 1 1 0 Flavodoxin DisA_N PF02457.16 ETO13591.1 - 3.4e-19 68.6 0.0 8.3e-19 67.3 0.0 1.7 1 0 0 1 1 1 1 DisA bacterial checkpoint controller nucleotide-binding CENP-B_dimeris PF09026.10 ETO13591.1 - 0.0048 17.3 14.2 0.019 15.3 14.2 2.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain TFIIA PF03153.13 ETO13593.1 - 0.0022 18.0 47.6 0.0028 17.7 47.6 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Ribosomal_60s PF00428.19 ETO13593.1 - 0.54 10.9 9.9 0.098 13.3 6.1 1.8 1 1 0 1 1 1 0 60s Acidic ribosomal protein DUF4746 PF15928.5 ETO13593.1 - 4.2 6.7 26.6 0.55 9.6 7.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) CytochromB561_N PF09786.9 ETO13593.1 - 4.7 6.1 25.4 5.7 5.8 25.4 1.0 1 0 0 1 1 1 0 Cytochrome B561, N terminal SDA1 PF05285.12 ETO13595.1 - 5.7e-45 154.3 28.1 5.7e-45 154.3 28.1 2.7 2 1 0 2 2 2 1 SDA1 Acetyltransf_6 PF13480.7 ETO13595.1 - 0.004 17.3 0.5 0.011 15.9 0.0 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain DUF1548 PF07579.11 ETO13595.1 - 0.049 14.0 0.7 0.09 13.1 0.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1548) NPV_P10 PF05531.12 ETO13595.1 - 0.12 12.9 0.5 0.3 11.6 0.5 1.6 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein NOA36 PF06524.12 ETO13595.1 - 5.9 6.1 13.3 17 4.6 13.3 1.7 1 0 0 1 1 1 0 NOA36 protein zf-RING_2 PF13639.6 ETO13596.1 - 9.4e-14 51.5 4.9 9.4e-14 51.5 4.9 1.9 2 0 0 2 2 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO13596.1 - 1.1e-08 34.8 6.0 3e-08 33.3 6.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO13596.1 - 6.4e-07 29.0 2.0 1.5e-06 27.8 2.0 1.6 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ETO13596.1 - 7.5e-07 28.9 2.8 1.8e-06 27.7 2.8 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO13596.1 - 1.5e-06 27.9 4.2 4.1e-06 26.6 4.2 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO13596.1 - 2.8e-06 27.5 7.4 2.8e-06 27.5 7.4 2.6 3 1 0 3 3 1 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETO13596.1 - 3.8e-06 26.8 1.1 1e-05 25.5 1.1 1.8 1 1 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO13596.1 - 4.2e-05 23.4 3.2 0.00012 22.0 3.2 1.8 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ETO13596.1 - 6.4e-05 22.5 4.3 0.00015 21.3 4.3 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ETO13596.1 - 0.0044 17.0 4.1 0.03 14.4 4.1 2.3 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO13596.1 - 0.0048 16.7 4.5 0.045 13.6 4.5 2.3 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 DUF3039 PF11238.8 ETO13596.1 - 0.011 15.5 0.7 0.024 14.4 0.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3039) AAA_lid_7 PF17867.1 ETO13596.1 - 0.013 15.7 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 Midasin AAA lid domain zf-RING-like PF08746.11 ETO13596.1 - 0.019 15.3 2.8 0.054 13.8 2.8 1.8 1 0 0 1 1 1 0 RING-like domain FANCL_C PF11793.8 ETO13596.1 - 0.048 13.8 5.2 0.48 10.6 5.2 2.5 1 1 0 1 1 1 0 FANCL C-terminal domain Zf_RING PF16744.5 ETO13596.1 - 0.1 12.7 2.9 0.36 11.0 2.9 2.0 1 0 0 1 1 1 0 KIAA1045 RING finger zf-RING_10 PF16685.5 ETO13596.1 - 0.21 11.8 7.0 0.3 11.2 3.4 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Prok-RING_1 PF14446.6 ETO13596.1 - 0.27 11.2 6.0 0.14 12.1 0.7 2.7 3 0 0 3 3 2 0 Prokaryotic RING finger family 1 Zn-ribbon_8 PF09723.10 ETO13596.1 - 0.69 10.1 4.2 1.1 9.4 0.3 2.8 3 0 0 3 3 3 0 Zinc ribbon domain zinc-ribbons_6 PF07191.12 ETO13596.1 - 1.6 8.8 6.6 0.26 11.3 2.2 2.0 2 0 0 2 2 2 0 zinc-ribbons DUF1272 PF06906.11 ETO13596.1 - 1.7 8.8 5.1 1.1 9.4 2.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) DZR PF12773.7 ETO13596.1 - 5.5 7.1 7.6 0.3 11.2 1.5 2.1 2 0 0 2 2 2 0 Double zinc ribbon zf-RING_4 PF14570.6 ETO13596.1 - 9.9 6.1 10.0 0.56 10.0 3.5 2.3 2 1 1 3 3 3 0 RING/Ubox like zinc-binding domain ECH_2 PF16113.5 ETO13597.1 - 7.1e-15 55.3 0.0 6.8e-09 35.7 0.0 2.2 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase SGS PF05002.15 ETO13597.1 - 0.012 15.7 0.0 0.037 14.2 0.0 1.7 1 0 0 1 1 1 0 SGS domain Exo_endo_phos PF03372.23 ETO13598.1 - 2.6e-05 23.9 0.0 3.6e-05 23.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RGS PF00615.19 ETO13599.1 - 6.3e-12 45.8 2.9 1.2e-11 45.0 2.9 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Presenilin PF01080.17 ETO13599.1 - 1.4 7.6 7.5 2.2 6.9 7.5 1.2 1 0 0 1 1 1 0 Presenilin Chibby PF14645.6 ETO13600.1 - 0.04 14.3 0.0 0.076 13.4 0.0 1.4 1 0 0 1 1 1 0 Chibby family EGF_2 PF07974.13 ETO13601.1 - 3.6e-05 24.0 3.2 8.3e-05 22.9 3.2 1.6 1 0 0 1 1 1 1 EGF-like domain ATG27 PF09451.10 ETO13601.1 - 0.00052 19.9 1.8 0.00062 19.7 0.2 1.9 2 1 0 2 2 2 1 Autophagy-related protein 27 EGF PF00008.27 ETO13601.1 - 0.0023 18.2 2.5 0.0047 17.2 2.5 1.5 1 0 0 1 1 1 1 EGF-like domain CD34_antigen PF06365.12 ETO13601.1 - 0.012 15.2 0.0 0.017 14.7 0.0 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family Peptidase_M56 PF05569.11 ETO13601.1 - 0.013 14.7 0.0 0.019 14.2 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 LRR19-TM PF15176.6 ETO13601.1 - 0.017 15.1 0.1 0.033 14.2 0.1 1.5 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain MARVEL PF01284.23 ETO13601.1 - 0.021 14.9 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Membrane-associating domain DUF3290 PF11694.8 ETO13601.1 - 0.033 14.2 2.7 0.035 14.1 0.4 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) Laminin_EGF PF00053.24 ETO13601.1 - 0.05 13.7 1.6 0.11 12.7 1.6 1.6 1 0 0 1 1 1 0 Laminin EGF domain hEGF PF12661.7 ETO13601.1 - 0.056 14.1 1.6 0.18 12.5 1.6 1.9 1 0 0 1 1 1 0 Human growth factor-like EGF SpoIIIAH PF12685.7 ETO13601.1 - 0.061 13.1 0.1 0.088 12.6 0.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein ANAPC16 PF17256.2 ETO13601.1 - 0.23 11.8 0.7 0.91 9.9 0.3 2.1 2 1 0 2 2 2 0 Anaphase-promoting complex, subunit 16 EGF_alliinase PF04863.13 ETO13601.1 - 0.41 11.1 6.1 0.74 10.3 6.1 1.4 1 0 0 1 1 1 0 Alliinase EGF-like domain EGF_Tenascin PF18720.1 ETO13601.1 - 1.1 9.4 6.0 4.1 7.6 6.0 2.0 1 1 0 1 1 1 0 Tenascin EGF domain Pkinase PF00069.25 ETO13603.1 - 5.7e-32 111.1 10.4 2.5e-30 105.7 10.4 3.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13603.1 - 2.4e-13 50.0 4.4 6.2e-13 48.6 0.2 2.9 1 1 1 3 3 3 1 Protein tyrosine kinase APH PF01636.23 ETO13603.1 - 0.17 11.8 0.2 0.31 10.9 0.2 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 ETO13603.1 - 0.35 10.5 5.4 0.2 11.2 1.1 2.8 3 1 0 3 3 3 0 RIO1 family DMP12 PF16779.5 ETO13604.1 - 0.002 18.1 0.1 0.0048 16.9 0.1 1.6 1 0 0 1 1 1 1 DNA-mimic protein CelTOS PF18659.1 ETO13604.1 - 0.18 12.3 3.1 1.8 9.0 0.3 2.7 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites Prenyltrans PF00432.21 ETO13606.1 - 1.7e-33 114.0 7.0 1.9e-11 43.5 0.0 4.3 4 1 0 4 4 4 4 Prenyltransferase and squalene oxidase repeat HEAT_PBS PF03130.16 ETO13606.1 - 0.065 13.9 0.0 0.23 12.3 0.0 1.9 1 0 0 1 1 1 0 PBS lyase HEAT-like repeat DUF5366 PF17328.2 ETO13607.1 - 0.0026 17.9 0.4 0.005 17.0 0.4 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5366) zf-RING_13 PF17977.1 ETO13607.1 - 0.019 15.1 2.2 0.061 13.5 2.2 2.0 1 1 0 1 1 1 0 RING/Ubox like zinc-binding domain DUF1365 PF07103.11 ETO13607.1 - 0.041 13.5 0.0 0.051 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1365) Ninjurin PF04923.12 ETO13607.1 - 0.061 13.3 1.3 0.58 10.1 1.0 2.1 1 1 1 2 2 2 0 Ninjurin AAA_16 PF13191.6 ETO13608.1 - 7.2e-05 23.2 0.0 0.00016 22.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain PH PF00169.29 ETO13608.1 - 0.02 15.4 0.0 0.077 13.5 0.0 2.0 1 0 0 1 1 1 0 PH domain Peptidase_S10 PF00450.22 ETO13609.1 - 1.1e-24 87.6 0.0 1.3e-24 87.4 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase IBB PF01749.20 ETO13610.1 - 9.7e-08 32.3 12.1 1.4e-07 31.8 12.1 1.2 1 0 0 1 1 1 1 Importin beta binding domain MPM1 PF17234.2 ETO13610.1 - 2.2 8.5 10.8 2.5 8.3 10.4 1.4 1 1 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 NOA36 PF06524.12 ETO13610.1 - 4 6.7 11.3 4.9 6.4 11.3 1.1 1 0 0 1 1 1 0 NOA36 protein FAM60A PF15396.6 ETO13610.1 - 4 7.4 10.5 4.7 7.2 10.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Arm PF00514.23 ETO13611.1 - 1.3e-24 85.4 5.7 1.6e-09 37.5 0.0 5.0 4 1 0 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO13611.1 - 2e-07 31.4 1.0 7.2e-05 23.2 0.1 2.8 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 ETO13611.1 - 0.0003 21.1 0.2 0.001 19.4 0.2 2.0 1 1 0 1 1 1 1 HEAT repeats RICTOR_V PF14668.6 ETO13611.1 - 0.0071 16.6 0.1 0.25 11.6 0.0 2.4 1 1 1 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.22 ETO13611.1 - 0.018 15.3 0.5 1 9.8 0.0 3.3 3 0 0 3 3 3 0 HEAT repeat HEAT_PBS PF03130.16 ETO13611.1 - 0.021 15.5 0.4 7.6 7.5 0.1 2.8 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat PEP-utilizers PF00391.23 ETO13611.1 - 0.091 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 PEP-utilising enzyme, mobile domain OrfB_Zn_ribbon PF07282.11 ETO13613.1 - 0.078 12.9 0.1 0.16 11.9 0.1 1.5 1 0 0 1 1 1 0 Putative transposase DNA-binding domain UDPG_MGDP_dh PF00984.19 ETO13613.1 - 0.094 12.9 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, central domain Stk19 PF10494.9 ETO13614.1 - 0.049 13.3 0.6 0.075 12.7 0.6 1.3 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 Arnt_C PF18583.1 ETO13614.1 - 0.077 12.6 1.2 0.18 11.4 0.5 1.9 1 1 1 2 2 2 0 Aminoarabinose transferase C-terminal domain DUF3015 PF11220.8 ETO13614.1 - 0.12 12.2 1.2 0.25 11.2 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3015) YABBY PF04690.13 ETO13614.1 - 1.8 9.1 7.6 0.19 12.3 1.5 2.0 2 0 0 2 2 2 0 YABBY protein Ribosomal_L6e PF01159.19 ETO13614.1 - 7 7.2 16.5 5.2 7.7 5.7 2.4 2 0 0 2 2 2 0 Ribosomal protein L6e Beach PF02138.18 ETO13615.1 - 5e-83 278.7 1.9 6.6e-82 275.0 1.9 2.3 1 1 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO13615.1 - 3.3e-15 56.0 0.2 1.3e-12 47.7 0.3 4.0 6 0 0 6 6 6 2 PH domain associated with Beige/BEACH Methyltransf_12 PF08242.12 ETO13615.1 - 4 8.3 6.4 4.6 8.1 0.2 2.6 2 0 0 2 2 2 0 Methyltransferase domain SusD-like_3 PF14322.6 ETO13615.1 - 4.5 7.5 14.2 0.13 12.5 3.4 2.5 2 0 0 2 2 2 0 Starch-binding associating with outer membrane Secretin_N_2 PF07655.13 ETO13615.1 - 9.4 6.9 32.3 1.7 9.3 9.4 3.0 3 0 0 3 3 3 0 Secretin N-terminal domain Beach PF02138.18 ETO13616.1 - 1.6e-32 113.0 0.0 3.1e-32 112.1 0.0 1.5 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 ETO13616.1 - 7.8e-07 29.7 0.9 0.035 15.0 0.0 5.1 4 1 1 5 5 5 2 WD domain, G-beta repeat eIF2A PF08662.11 ETO13616.1 - 0.015 15.1 0.1 3.6 7.4 0.0 2.9 3 1 0 3 3 3 0 Eukaryotic translation initiation factor eIF2A Cytochrome_CBB3 PF13442.6 ETO13618.1 - 0.24 11.7 1.1 0.37 11.1 0.4 1.7 2 0 0 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III DUF1772 PF08592.11 ETO13618.1 - 5.4 7.3 6.1 4.8 7.5 0.6 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) PHO4 PF01384.20 ETO13618.1 - 9.3 5.2 6.8 0.86 8.6 2.3 1.6 2 0 0 2 2 2 0 Phosphate transporter family DHHC PF01529.20 ETO13619.1 - 0.76 9.9 9.0 0.28 11.3 5.7 2.0 2 0 0 2 2 2 0 DHHC palmitoyltransferase LIAS_N PF16881.5 ETO13620.1 - 4.2e-19 69.0 2.4 1.6e-16 60.7 1.3 3.2 2 1 0 3 3 3 1 N-terminal domain of lipoyl synthase of Radical_SAM family Radical_SAM PF04055.21 ETO13620.1 - 2.4e-08 34.5 0.0 8e-08 32.8 0.0 2.0 2 0 0 2 2 2 1 Radical SAM superfamily Ivy PF08816.11 ETO13620.1 - 0.0099 16.1 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 1 Inhibitor of vertebrate lysozyme (Ivy) WD40 PF00400.32 ETO13621.1 - 4.7e-53 176.0 18.2 7e-09 36.2 0.1 8.4 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13621.1 - 5.8e-14 52.2 5.4 0.0096 16.2 0.0 6.9 2 1 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13621.1 - 8.4e-12 44.7 1.7 0.07 12.1 0.0 6.6 3 1 4 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_2 PF07646.15 ETO13621.1 - 1.6e-05 24.7 6.6 0.0076 16.2 0.2 4.3 3 1 0 3 3 3 2 Kelch motif Cytochrom_D1 PF02239.16 ETO13621.1 - 2e-05 23.3 9.7 0.081 11.4 0.1 4.4 2 1 3 5 5 5 4 Cytochrome D1 heme domain Kelch_6 PF13964.6 ETO13621.1 - 3.7e-05 23.8 3.2 0.076 13.3 0.0 4.0 3 0 0 3 3 3 1 Kelch motif Nup160 PF11715.8 ETO13621.1 - 0.0001 21.1 4.9 1.3 7.6 0.1 4.1 2 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO13621.1 - 0.00034 20.0 10.9 0.011 15.1 0.0 4.4 3 1 0 3 3 3 1 WD40-like domain Kelch_4 PF13418.6 ETO13621.1 - 0.0032 17.4 5.6 0.039 14.0 0.0 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO13621.1 - 0.0033 17.0 2.0 1.1 8.8 0.1 3.4 3 0 0 3 3 3 1 Kelch motif PD40 PF07676.12 ETO13621.1 - 0.0037 17.2 4.8 6.4 6.8 0.1 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO13621.1 - 0.0096 15.9 6.1 3.7 7.6 0.0 4.7 5 0 0 5 5 5 2 Kelch motif DUF2272 PF10030.9 ETO13621.1 - 0.017 14.9 1.0 0.066 13.0 0.0 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_3 PF13415.6 ETO13621.1 - 0.16 12.3 0.7 4.5 7.7 0.0 3.1 3 0 0 3 3 2 0 Galactose oxidase, central domain BAF1_ABF1 PF04684.13 ETO13623.1 - 0.19 10.8 27.5 0.21 10.6 27.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor PI3K_1B_p101 PF10486.9 ETO13623.1 - 0.27 9.0 17.1 0.31 8.8 17.1 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Hid1 PF12722.7 ETO13623.1 - 1.7 6.7 18.0 1.9 6.5 18.0 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Nop14 PF04147.12 ETO13623.1 - 3.4 5.8 34.6 4.1 5.5 34.6 1.1 1 0 0 1 1 1 0 Nop14-like family Dynamitin PF04912.14 ETO13624.1 - 3.5e-15 56.2 10.6 4.1e-15 56.0 10.6 1.0 1 0 0 1 1 1 1 Dynamitin PilJ PF13675.6 ETO13624.1 - 0.036 14.1 1.9 0.086 12.9 1.9 1.6 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term EMP24_GP25L PF01105.24 ETO13624.1 - 0.46 10.4 6.3 0.058 13.3 1.7 1.9 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD IL2 PF00715.17 ETO13624.1 - 0.66 9.9 4.1 1.3 8.9 4.1 1.5 1 0 0 1 1 1 0 Interleukin 2 Clathrin PF00637.20 ETO13625.1 - 3.1e-06 27.1 10.1 2.8e-05 24.0 1.0 2.8 3 0 0 3 3 3 2 Region in Clathrin and VPS DUF4061 PF13270.6 ETO13625.1 - 0.11 12.8 8.4 2.4 8.5 5.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) THF_DHG_CYH PF00763.23 ETO13625.1 - 0.12 12.7 3.5 1.3 9.3 0.0 3.0 3 0 0 3 3 3 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain TPR_2 PF07719.17 ETO13626.1 - 0.0024 17.8 0.5 0.07 13.3 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO13626.1 - 0.0047 17.4 0.0 1.8 9.1 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO13626.1 - 0.0081 16.4 0.0 0.12 12.7 0.0 2.4 2 1 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETO13626.1 - 0.012 15.6 0.0 0.038 14.1 0.0 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Sec3_C PF09763.9 ETO13626.1 - 0.018 13.5 0.6 0.022 13.2 0.6 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec3 VAD1-2 PF15310.6 ETO13626.1 - 0.08 12.8 6.0 0.1 12.4 6.0 1.1 1 0 0 1 1 1 0 Vitamin A-deficiency (VAD) rat model signalling SR-25 PF10500.9 ETO13626.1 - 0.18 11.4 11.9 0.25 10.9 11.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF5470 PF17564.2 ETO13626.1 - 5 7.4 7.8 9.8 6.5 7.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5470) IMUP PF15761.5 ETO13626.1 - 7.7 7.3 11.0 11 6.7 11.0 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein SRP54 PF00448.22 ETO13628.1 - 1.3e-73 246.8 0.2 2.2e-73 246.1 0.2 1.4 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ETO13628.1 - 9.9e-24 83.8 4.7 2.2e-23 82.8 0.1 2.9 2 0 0 2 2 2 1 Signal peptide binding domain SRP54_N PF02881.19 ETO13628.1 - 3e-13 49.8 3.5 3e-13 49.8 3.5 2.4 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 ETO13628.1 - 2.2e-05 24.5 0.0 0.00018 21.6 0.0 2.4 2 1 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain MeaB PF03308.16 ETO13628.1 - 0.00014 20.9 0.1 0.00037 19.6 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ETO13628.1 - 0.0033 17.6 0.1 0.011 15.9 0.1 2.1 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO13628.1 - 0.0066 16.8 0.5 0.11 12.9 0.0 2.9 3 0 0 3 3 3 1 AAA ATPase domain MobB PF03205.14 ETO13628.1 - 0.012 15.5 0.1 0.036 14.0 0.0 1.9 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_18 PF13238.6 ETO13628.1 - 0.02 15.4 0.9 0.06 13.9 0.1 2.4 3 1 0 3 3 3 0 AAA domain AAA_17 PF13207.6 ETO13628.1 - 0.023 15.1 1.4 0.11 12.9 0.0 2.8 2 1 1 3 3 3 0 AAA domain 6PF2K PF01591.18 ETO13628.1 - 0.024 14.0 0.1 0.084 12.2 0.0 1.9 2 0 0 2 2 2 0 6-phosphofructo-2-kinase cobW PF02492.19 ETO13628.1 - 0.051 13.2 6.7 1 8.9 4.6 3.0 2 1 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain AAA_24 PF13479.6 ETO13628.1 - 0.052 13.3 0.0 0.11 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain APS_kinase PF01583.20 ETO13628.1 - 0.062 13.2 0.0 0.15 11.9 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase AAA_31 PF13614.6 ETO13628.1 - 0.093 12.6 1.8 0.23 11.4 0.0 2.6 3 1 0 3 3 3 0 AAA domain AAA_14 PF13173.6 ETO13628.1 - 0.1 12.6 1.9 1.7 8.7 0.4 3.1 2 1 0 2 2 2 0 AAA domain RE_HindIII PF09518.10 ETO13628.1 - 0.12 11.5 0.8 0.25 10.5 0.2 1.8 2 0 0 2 2 2 0 HindIII restriction endonuclease ResIII PF04851.15 ETO13628.1 - 0.14 12.1 1.4 0.39 10.7 0.6 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit ATP_bind_1 PF03029.17 ETO13628.1 - 0.2 11.4 0.1 0.2 11.4 0.1 2.6 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein AAA_22 PF13401.6 ETO13628.1 - 0.91 9.8 5.5 0.97 9.7 0.7 3.2 3 1 0 3 3 3 0 AAA domain AAA PF00004.29 ETO13628.1 - 0.98 9.9 4.8 3.2 8.2 0.6 3.2 3 1 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) Aldo_ket_red PF00248.21 ETO13629.1 - 3e-15 56.2 0.1 1.8e-13 50.3 0.0 2.2 1 1 1 2 2 2 2 Aldo/keto reductase family GAPT PF11770.8 ETO13631.1 - 0.31 10.9 1.4 0.76 9.6 1.4 1.7 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) Wzy_C PF04932.15 ETO13631.1 - 2.4 7.8 7.3 3.5 7.3 7.3 1.3 1 0 0 1 1 1 0 O-Antigen ligase Transferase PF02458.15 ETO13632.1 - 4.4e-08 32.2 0.0 5.2e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Transferase family Rrp15p PF07890.12 ETO13638.1 - 6.9e-11 42.6 8.9 6.9e-11 42.6 8.9 1.9 1 1 1 2 2 2 1 Rrp15p RRM_1 PF00076.22 ETO13639.1 - 1.7e-14 53.4 0.1 7.6e-07 28.9 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Lysozyme_like PF13702.6 ETO13640.1 - 0.067 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Lysozyme-like Tho2 PF11262.8 ETO13640.1 - 0.15 11.2 4.2 3.6 6.7 0.2 2.2 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Spore_coat_CotO PF14153.6 ETO13641.1 - 0.41 10.5 5.7 0.58 10.1 5.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Menin PF05053.13 ETO13641.1 - 1.1 7.6 5.6 1.5 7.1 5.6 1.2 1 0 0 1 1 1 0 Menin MRI PF15325.6 ETO13641.1 - 1.2 10.2 7.6 7.6 7.7 6.0 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection Lin-8 PF03353.15 ETO13641.1 - 2.1 7.8 8.4 2.9 7.4 8.4 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 ETO13641.1 - 2.4 6.8 5.7 2.7 6.6 5.7 1.2 1 0 0 1 1 1 0 Presenilin DUF3995 PF13160.6 ETO13642.1 - 0.013 15.9 0.2 0.22 11.9 0.0 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3995) SOAR PF16533.5 ETO13644.1 - 0.33 10.9 5.4 0.68 9.9 5.4 1.7 1 1 0 1 1 1 0 STIM1 Orai1-activating region RhoGAP PF00620.27 ETO13645.1 - 9.5e-05 22.3 0.0 0.00016 21.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Cyt_b-c1_8 PF10890.8 ETO13646.1 - 0.055 13.9 0.0 0.14 12.6 0.0 1.6 1 1 1 2 2 2 0 Cytochrome b-c1 complex subunit 8 MotCF PF09158.10 ETO13646.1 - 0.069 13.2 0.1 0.077 13.1 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage T4 MotA, C-terminal Cwf_Cwc_15 PF04889.12 ETO13647.1 - 0.0013 18.5 11.1 0.0026 17.5 11.1 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 ETO13647.1 - 0.01 15.0 18.5 0.022 13.9 18.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 ETO13647.1 - 0.045 13.2 14.5 0.088 12.2 14.5 1.4 1 0 0 1 1 1 0 SDA1 Raftlin PF15250.6 ETO13647.1 - 0.78 8.4 5.1 1.2 7.8 5.1 1.2 1 0 0 1 1 1 0 Raftlin DNA_pol_phi PF04931.13 ETO13647.1 - 3.7 5.5 17.2 4.8 5.2 17.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO13647.1 - 4.7 6.5 19.7 7.3 5.8 19.7 1.2 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ETO13647.1 - 6.9 4.8 14.1 9.6 4.4 14.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO13647.1 - 7.1 5.3 5.0 11 4.7 5.0 1.2 1 0 0 1 1 1 0 Presenilin LAP1C PF05609.12 ETO13647.1 - 7.8 5.5 13.8 13 4.7 13.8 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Sporozoite_P67 PF05642.11 ETO13647.1 - 8.1 4.4 12.0 12 3.8 12.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PI3Ka PF00613.20 ETO13648.1 - 4.1e-32 111.1 2.8 4.5e-32 111.0 2.8 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) HTH_16 PF12645.7 ETO13649.1 - 0.23 11.5 2.5 1 9.5 0.0 2.7 3 0 0 3 3 3 0 Helix-turn-helix domain THOC2_N PF16134.5 ETO13650.1 - 0.037 12.7 0.3 0.041 12.5 0.3 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus HEAT PF02985.22 ETO13650.1 - 0.045 14.0 0.0 1.5 9.3 0.0 2.3 2 0 0 2 2 2 0 HEAT repeat YL1 PF05764.13 ETO13651.1 - 0.0095 16.1 22.2 0.0095 16.1 22.2 2.2 2 0 0 2 2 2 1 YL1 nuclear protein Tim54 PF11711.8 ETO13651.1 - 0.23 10.2 26.3 0.0098 14.7 14.6 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SpoIIP PF07454.11 ETO13651.1 - 3.6 7.0 24.1 0.46 9.9 15.3 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) eIF3_subunit PF08597.10 ETO13651.1 - 4.8 7.0 38.4 7.5 6.4 29.0 2.3 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit Rib_recp_KP_reg PF05104.12 ETO13651.1 - 6.1 7.9 41.6 3.6 8.6 29.0 2.5 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Connexin PF00029.19 ETO13651.1 - 7.6 6.2 24.0 0.53 10.0 13.9 2.3 2 0 0 2 2 2 0 Connexin SOBP PF15279.6 ETO13651.1 - 9.4 6.7 20.9 1.1 9.8 10.7 2.2 2 0 0 2 2 2 0 Sine oculis-binding protein Aminotran_5 PF00266.19 ETO13652.1 - 3.2e-71 240.2 0.1 4.3e-42 144.4 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class-V Beta_elim_lyase PF01212.21 ETO13652.1 - 0.00039 19.8 0.0 0.15 11.3 0.0 2.1 2 0 0 2 2 2 2 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ETO13652.1 - 0.052 12.9 0.0 0.92 8.7 0.0 2.2 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Pyridoxal_deC PF00282.19 ETO13652.1 - 0.11 11.2 0.0 0.3 9.8 0.0 1.7 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain CRAL_TRIO PF00650.20 ETO13653.1 - 1.6e-19 70.2 3.4 1e-17 64.3 3.4 2.5 1 1 0 1 1 1 1 CRAL/TRIO domain RWD PF05773.22 ETO13653.1 - 0.015 15.5 0.9 0.16 12.3 0.0 2.6 2 0 0 2 2 2 0 RWD domain ThiP_synth PF10120.9 ETO13653.1 - 0.067 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 Thiamine-phosphate synthase Peroxin-13_N PF04088.13 ETO13654.1 - 6e-06 26.6 0.4 2.5e-05 24.6 0.0 2.2 1 1 1 2 2 2 1 Peroxin 13, N-terminal region FGF-BP1 PF06473.12 ETO13654.1 - 0.00071 19.5 0.0 0.0013 18.6 0.0 1.3 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) PTPRCAP PF15713.5 ETO13654.1 - 0.0079 16.5 0.5 0.016 15.5 0.5 1.4 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated CLN3 PF02487.17 ETO13655.1 - 0.19 10.7 5.5 3.4 6.6 1.6 2.1 2 0 0 2 2 2 0 CLN3 protein DAG_kinase_N PF14513.6 ETO13655.1 - 3.5 7.8 13.3 0.81 9.9 6.4 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus HTH_38 PF13936.6 ETO13656.1 - 0.088 12.6 0.2 0.22 11.3 0.0 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain Orf78 PF06024.12 ETO13656.1 - 0.13 12.5 0.7 0.18 12.1 0.7 1.2 1 0 0 1 1 1 0 Orf78 (ac78) SNase PF00565.17 ETO13657.1 - 0.00096 19.6 0.2 0.0014 19.1 0.2 1.3 1 0 0 1 1 1 1 Staphylococcal nuclease homologue Ste5_C PF12194.8 ETO13657.1 - 0.0016 18.4 0.1 0.0029 17.6 0.1 1.3 1 0 0 1 1 1 1 Protein kinase Fus3-binding Vfa1 PF08432.10 ETO13658.1 - 6.8 7.0 12.6 4 7.7 4.7 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 NiFe-hyd_HybE PF11939.8 ETO13659.1 - 0.14 12.1 1.3 0.27 11.1 1.3 1.4 1 0 0 1 1 1 0 [NiFe]-hydrogenase assembly, chaperone, HybE WD40 PF00400.32 ETO13660.1 - 3.7e-27 94.0 17.6 1e-05 26.2 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13660.1 - 6.8e-09 35.9 1.1 0.049 13.9 0.0 4.5 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13660.1 - 4.3e-07 29.0 4.0 0.099 11.3 0.3 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO13660.1 - 4.8e-06 27.2 1.9 4.8e-06 27.2 1.9 3.0 3 0 0 3 3 3 1 TRAF-type zinc finger WD40_like PF17005.5 ETO13660.1 - 4.2e-05 23.0 1.4 0.22 10.8 0.4 3.1 3 0 0 3 3 3 2 WD40-like domain Kelch_6 PF13964.6 ETO13660.1 - 0.027 14.8 6.6 0.04 14.2 0.2 3.5 3 1 0 3 3 3 0 Kelch motif zf-TRAF_2 PF15965.5 ETO13660.1 - 0.046 14.2 1.9 0.2 12.2 1.9 2.2 1 1 0 1 1 1 0 TRAF-like zinc-finger DUF3584 PF12128.8 ETO13660.1 - 0.083 10.4 19.9 0.13 9.8 19.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF4047 PF13256.6 ETO13660.1 - 4.1 7.6 16.7 13 6.0 1.3 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Rootletin PF15035.6 ETO13660.1 - 9.5 6.2 25.1 0.85 9.6 17.0 2.7 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Ras PF00071.22 ETO13661.1 - 1.6e-45 154.6 0.5 1.7e-45 154.5 0.5 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO13661.1 - 3.9e-21 75.5 0.1 6.1e-21 74.9 0.1 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO13661.1 - 6e-11 42.1 0.1 6.3e-11 42.0 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO13661.1 - 0.0078 15.8 0.0 0.018 14.6 0.0 1.6 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO13661.1 - 0.034 14.1 0.1 0.044 13.7 0.1 1.3 1 1 0 1 1 1 0 RsgA GTPase CENP-M PF11111.8 ETO13661.1 - 0.035 13.3 0.0 0.045 13.0 0.0 1.1 1 0 0 1 1 1 0 Centromere protein M (CENP-M) BAR_3 PF16746.5 ETO13662.1 - 1.2e-07 31.7 4.8 1.5e-07 31.4 4.8 1.2 1 0 0 1 1 1 1 BAR domain of APPL family TSNAXIP1_N PF15739.5 ETO13662.1 - 0.00037 20.8 6.8 0.00072 19.9 6.4 1.6 1 1 0 1 1 1 1 Translin-associated factor X-interacting N-terminus Arfaptin PF06456.13 ETO13662.1 - 0.0033 17.0 5.5 0.0056 16.3 5.5 1.4 1 0 0 1 1 1 1 Arfaptin-like domain ThiC-associated PF13667.6 ETO13662.1 - 0.42 10.5 3.4 0.24 11.3 0.7 2.1 2 1 0 2 2 2 0 ThiC-associated domain Peptidase_C98 PF15499.6 ETO13662.1 - 2.3 7.6 7.8 0.18 11.3 2.6 1.7 2 0 0 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase C2 PF00168.30 ETO13663.1 - 0.0013 18.9 0.1 0.016 15.5 0.0 2.2 2 0 0 2 2 2 1 C2 domain Noelin-1 PF12308.8 ETO13663.1 - 0.0055 16.7 0.3 4.4 7.4 0.0 2.9 2 0 0 2 2 2 2 Neurogenesis glycoprotein Telomere_reg-2 PF10193.9 ETO13663.1 - 0.014 15.9 0.3 0.053 14.0 0.0 2.1 2 0 0 2 2 2 0 Telomere length regulation protein FA_desaturase PF00487.24 ETO13664.1 - 3.2 7.5 7.0 4.7 7.0 7.0 1.2 1 0 0 1 1 1 0 Fatty acid desaturase Pkinase PF00069.25 ETO13665.1 - 1.7e-55 188.2 0.0 2e-55 188.0 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13665.1 - 3.7e-24 85.4 0.0 4.8e-24 85.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO13665.1 - 1e-08 34.9 0.0 1.6e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO13665.1 - 3.8e-07 30.3 0.0 2.3e-06 27.7 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO13665.1 - 4.1e-05 22.5 0.0 5.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO13665.1 - 6.8e-05 22.3 0.0 0.00016 21.1 0.0 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO13665.1 - 0.0048 16.5 0.0 0.012 15.2 0.0 1.6 2 0 0 2 2 2 1 Choline/ethanolamine kinase RIO1 PF01163.22 ETO13665.1 - 0.19 11.3 0.0 0.29 10.7 0.0 1.3 1 0 0 1 1 1 0 RIO1 family RabGAP-TBC PF00566.18 ETO13666.1 - 2.3e-10 40.5 2.5 4.8e-10 39.5 2.5 1.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain RL PF17797.1 ETO13667.1 - 0.072 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 RL domain DUF1459 PF07312.11 ETO13667.1 - 1.1 9.5 6.0 2.2 8.5 6.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1459) NPCBM_assoc PF10633.9 ETO13668.1 - 0.37 11.1 6.4 0.67 10.2 4.2 2.2 1 1 1 2 2 2 0 NPCBM-associated, NEW3 domain of alpha-galactosidase Zip PF02535.22 ETO13671.1 - 3.1 6.9 5.3 0.54 9.4 1.3 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter LSM PF01423.22 ETO13672.1 - 7.4e-21 73.6 0.4 1.3e-20 72.8 0.4 1.4 1 0 0 1 1 1 1 LSM domain Toprim_Crpt PF13342.6 ETO13673.1 - 0.035 14.1 1.4 0.32 11.0 0.1 2.6 1 1 1 2 2 2 0 C-terminal repeat of topoisomerase Tweety PF04906.13 ETO13673.1 - 0.1 11.3 0.2 0.12 11.0 0.2 1.1 1 0 0 1 1 1 0 Tweety DUF4242 PF14026.6 ETO13674.1 - 0.031 14.5 0.1 0.069 13.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) TEX19 PF15553.6 ETO13674.1 - 0.084 12.8 0.2 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 Testis-expressed protein 19 DUF5635 PF18685.1 ETO13675.1 - 0.14 12.1 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5635) TPR_MLP1_2 PF07926.12 ETO13676.1 - 4.8e-06 26.6 14.1 4.8e-06 26.6 14.1 4.4 2 1 2 4 4 4 2 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ETO13676.1 - 0.00067 18.6 13.9 0.00067 18.6 13.9 2.6 1 1 1 2 2 2 2 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ETO13676.1 - 0.0043 17.1 8.1 0.0043 17.1 8.1 3.8 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 EzrA PF06160.12 ETO13676.1 - 0.064 11.4 36.1 0.012 13.9 13.7 3.3 1 1 2 3 3 3 0 Septation ring formation regulator, EzrA FlaC_arch PF05377.11 ETO13676.1 - 0.069 13.6 25.6 0.24 11.8 0.7 6.2 3 1 3 6 6 6 0 Flagella accessory protein C (FlaC) Rab5-bind PF09311.11 ETO13676.1 - 0.78 9.1 42.0 0.057 12.8 26.0 2.2 1 1 1 2 2 2 0 Rabaptin-like protein UPF0688 PF15772.5 ETO13676.1 - 0.96 9.7 20.0 0.36 11.0 10.4 2.4 2 1 0 2 2 2 0 UPF0688 family APG6_N PF17675.1 ETO13676.1 - 1.5 9.3 48.7 1.5 9.4 10.4 4.1 2 1 2 4 4 4 0 Apg6 coiled-coil region DUF3800 PF12686.7 ETO13676.1 - 1.7 9.3 4.8 38 4.9 4.9 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) ERM PF00769.19 ETO13676.1 - 1.9 8.3 49.0 0.25 11.1 12.5 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family GAS PF13851.6 ETO13676.1 - 2.2 7.6 45.0 0.78 9.1 9.3 3.7 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding SHE3 PF17078.5 ETO13676.1 - 2.6 7.7 40.0 2 8.1 12.6 3.4 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 AcylCoA_dehyd_C PF12186.8 ETO13676.1 - 3.8 7.7 15.4 7.5 6.7 1.3 3.7 2 1 0 3 3 3 0 Acyl-CoA dehydrogenase C terminal DUF3810 PF12725.7 ETO13676.1 - 4.1 6.7 18.6 0.25 10.7 8.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) CALCOCO1 PF07888.11 ETO13676.1 - 4.2 6.1 38.9 1.2 8.0 23.7 2.6 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like ATG16 PF08614.11 ETO13676.1 - 4.2 7.6 47.4 3.9 7.6 6.2 4.1 2 1 1 4 4 4 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 ETO13676.1 - 4.8 7.4 47.0 2.2 8.5 23.5 3.6 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 DUF5082 PF16888.5 ETO13676.1 - 6.3 7.1 33.6 1.5 9.1 6.5 5.6 2 1 4 6 6 5 0 Domain of unknown function (DUF5082) Golgin_A5 PF09787.9 ETO13676.1 - 6.8 6.1 44.3 0.43 10.0 32.2 2.7 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF3584 PF12128.8 ETO13676.1 - 9.1 3.6 39.6 0.084 10.4 23.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF4201 PF13870.6 ETO13676.1 - 9.8 5.9 38.0 1.9 8.2 6.1 3.7 1 1 1 2 2 1 0 Domain of unknown function (DUF4201) SSV1_ORF_D-335 PF07935.11 ETO13678.1 - 0.042 14.1 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 ORF D-335-like protein TMEM237 PF15383.6 ETO13678.1 - 0.057 12.5 0.0 0.12 11.4 0.0 1.5 1 0 0 1 1 1 0 Transmembrane protein 237 DUF3228 PF11539.8 ETO13679.1 - 6.1e-81 270.6 0.0 7.4e-81 270.3 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3228) Crinivirus_P26 PF07416.11 ETO13679.1 - 0.0056 16.4 0.1 0.0089 15.8 0.1 1.2 1 0 0 1 1 1 1 Crinivirus P26 protein CBFD_NFYB_HMF PF00808.23 ETO13679.1 - 0.16 12.3 0.1 0.4 11.0 0.1 1.7 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF747 PF05346.11 ETO13680.1 - 2e-50 172.1 11.1 2.4e-50 171.8 11.1 1.0 1 0 0 1 1 1 1 Eukaryotic membrane protein family DUF2663 PF10864.8 ETO13680.1 - 0.63 10.4 4.9 0.35 11.3 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) ATG16 PF08614.11 ETO13681.1 - 0.087 13.0 0.3 0.087 13.0 0.3 4.4 3 2 1 4 4 4 0 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.11 ETO13681.1 - 3 8.5 35.4 1.3 9.7 6.4 4.6 3 2 1 4 4 4 0 Syntaxin 6, N-terminal Phage_GP20 PF06810.11 ETO13681.1 - 6.2 6.6 48.8 0.49 10.2 5.8 5.2 4 1 1 5 5 5 0 Phage minor structural protein GP20 Cep57_CLD_2 PF14197.6 ETO13682.1 - 0.0039 17.3 11.3 0.0039 17.3 11.3 6.3 3 2 5 8 8 8 1 Centrosome localisation domain of PPC89 Spc7 PF08317.11 ETO13682.1 - 0.0066 15.4 24.8 0.0066 15.4 24.8 3.1 1 1 2 3 3 3 1 Spc7 kinetochore protein Band_7_1 PF13421.6 ETO13682.1 - 2.5 7.7 7.1 2 8.1 2.1 2.4 2 1 0 2 2 2 0 SPFH domain-Band 7 family zf-MYND PF01753.18 ETO13683.1 - 5.2e-08 32.8 9.6 5.2e-08 32.8 9.6 2.2 2 0 0 2 2 2 1 MYND finger DUF3340 PF11818.8 ETO13683.1 - 0.48 10.6 13.6 0.2 11.8 10.8 1.7 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) RP-C_C PF11800.8 ETO13683.1 - 3.2 7.8 8.8 6.3 6.8 8.8 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region RhoGEF PF00621.20 ETO13684.1 - 3e-09 37.4 0.3 3.6e-09 37.1 0.3 1.1 1 0 0 1 1 1 1 RhoGEF domain TFIIA PF03153.13 ETO13685.1 - 0.56 10.1 35.6 0.73 9.8 35.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 ETO13685.1 - 2.4 6.3 29.1 2.6 6.2 29.1 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOG2 PF10428.9 ETO13685.1 - 2.9 7.0 23.9 3.2 6.8 23.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein VASt PF16016.5 ETO13686.1 - 3.2e-20 73.1 0.3 3.2e-20 73.1 0.3 2.0 2 0 0 2 2 2 1 VAD1 Analog of StAR-related lipid transfer domain SR-25 PF10500.9 ETO13688.1 - 0.23 11.0 3.6 0.4 10.3 3.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dmrt1 PF12374.8 ETO13688.1 - 0.53 10.8 7.1 0.45 11.0 3.3 2.6 3 0 0 3 3 3 0 Double-sex mab3 related transcription factor 1 BSP_II PF05432.11 ETO13689.1 - 0.0055 16.4 24.4 0.0077 16.0 24.4 1.2 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 ETO13689.1 - 0.086 12.3 22.1 0.11 11.9 22.1 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO13689.1 - 0.16 10.1 20.5 0.19 9.9 20.5 1.2 1 0 0 1 1 1 0 Nop14-like family Neur_chan_memb PF02932.16 ETO13689.1 - 0.38 10.8 4.3 0.7 9.9 4.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 ETO13689.1 - 3.9 5.5 12.7 4.6 5.3 12.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RGS PF00615.19 ETO13690.1 - 0.0019 18.4 12.5 0.042 14.1 1.1 3.7 3 1 0 3 3 3 2 Regulator of G protein signaling domain VIR_N PF15912.5 ETO13690.1 - 0.029 14.0 4.1 0.045 13.4 4.1 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal CAP_N PF01213.19 ETO13690.1 - 0.45 9.9 5.1 0.26 10.7 2.1 1.9 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal MFAP1 PF06991.11 ETO13691.1 - 0.021 14.6 3.1 0.039 13.8 3.1 1.4 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing RPOL_N PF14700.6 ETO13691.1 - 0.053 12.9 0.9 0.091 12.1 0.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal RRN3 PF05327.11 ETO13691.1 - 1 7.8 4.4 1.6 7.2 4.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PPO1_DWL PF12142.8 ETO13692.1 - 0.23 11.3 4.4 0.61 9.9 0.3 2.8 2 1 1 3 3 3 0 Polyphenol oxidase middle domain PIG-F PF06699.11 ETO13692.1 - 0.32 11.2 2.6 2 8.5 0.4 2.2 2 0 0 2 2 2 0 GPI biosynthesis protein family Pig-F ERAP1_C PF11838.8 ETO13693.1 - 1.4e-70 238.3 0.6 1.6e-70 238.1 0.6 1.0 1 0 0 1 1 1 1 ERAP1-like C-terminal domain HEAT_2 PF13646.6 ETO13693.1 - 0.0015 18.9 0.0 0.087 13.2 0.0 2.8 2 0 0 2 2 2 1 HEAT repeats SesA PF17107.5 ETO13693.1 - 0.14 12.3 0.1 4.3 7.6 0.0 3.2 3 0 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Peptidase_M1 PF01433.20 ETO13694.1 - 3.5e-78 262.1 0.2 4.6e-78 261.7 0.2 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain FH2 PF02181.23 ETO13695.1 - 2.8e-91 306.4 9.3 2.8e-91 306.4 9.3 2.2 2 0 0 2 2 2 1 Formin Homology 2 Domain CCDC53 PF10152.9 ETO13695.1 - 9.3e-16 58.6 26.3 1.6e-07 31.9 0.0 5.0 5 0 0 5 5 5 4 Subunit CCDC53 of WASH complex PT PF04886.12 ETO13696.1 - 0.0025 17.3 21.3 0.03 13.9 21.3 2.5 1 1 0 1 1 1 1 PT repeat DUF1387 PF07139.11 ETO13696.1 - 0.18 11.5 20.7 0.23 11.1 20.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Nucleoside_tran PF01733.18 ETO13696.1 - 0.69 9.2 2.4 0.55 9.6 1.5 1.3 1 1 0 1 1 1 0 Nucleoside transporter AP1AR PF15745.5 ETO13696.1 - 1.3 8.5 9.4 20 4.7 9.3 2.3 2 1 0 2 2 2 0 AP-1 complex-associated regulatory protein AAA PF00004.29 ETO13697.1 - 7.9e-31 107.2 0.0 3.2e-30 105.2 0.0 2.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) MIT PF04212.18 ETO13697.1 - 1.8e-05 24.7 0.8 3.6e-05 23.8 0.8 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 ETO13697.1 - 2.1e-05 24.3 0.0 3.9e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETO13697.1 - 9.5e-05 22.7 0.2 0.14 12.5 0.0 2.5 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 ETO13697.1 - 0.00016 21.7 0.0 0.001 19.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ETO13697.1 - 0.0017 18.1 0.0 0.0099 15.6 0.0 2.0 2 0 0 2 2 2 1 IstB-like ATP binding protein TniB PF05621.11 ETO13697.1 - 0.0023 17.4 0.0 1.6 8.1 0.0 2.6 3 0 0 3 3 3 2 Bacterial TniB protein TIP49 PF06068.13 ETO13697.1 - 0.0027 16.9 0.2 0.0049 16.1 0.0 1.6 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_2 PF07724.14 ETO13697.1 - 0.0037 17.4 0.0 0.012 15.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ETO13697.1 - 0.0052 17.2 0.2 0.54 10.6 0.0 2.5 2 1 1 3 3 3 1 AAA ATPase domain AAA_33 PF13671.6 ETO13697.1 - 0.0072 16.5 0.0 0.036 14.2 0.0 2.0 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ETO13697.1 - 0.0083 16.2 0.0 0.028 14.5 0.0 1.8 2 0 0 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETO13697.1 - 0.015 14.7 0.5 0.047 13.1 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ETO13697.1 - 0.1 13.0 0.0 0.32 11.4 0.0 1.9 1 0 0 1 1 1 0 RNA helicase AAA_25 PF13481.6 ETO13697.1 - 0.13 11.8 0.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain CDC45 PF02724.14 ETO13698.1 - 0.72 8.1 11.5 0.8 7.9 11.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO13698.1 - 1.9 6.8 12.9 2.1 6.6 12.9 1.1 1 0 0 1 1 1 0 Menin Ureide_permease PF07168.11 ETO13698.1 - 4.7 5.9 5.5 5.3 5.7 5.5 1.2 1 0 0 1 1 1 0 Ureide permease LMBR1 PF04791.16 ETO13698.1 - 4.9 5.9 5.2 5.5 5.8 5.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Zip PF02535.22 ETO13698.1 - 7.9 5.6 7.2 9.2 5.4 7.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Lin-8 PF03353.15 ETO13698.1 - 8.3 5.9 13.1 10 5.5 13.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Presenilin PF01080.17 ETO13698.1 - 10 4.8 12.9 11 4.6 12.9 1.1 1 0 0 1 1 1 0 Presenilin REV1_C PF16727.5 ETO13699.1 - 0.0099 16.3 0.0 0.25 11.8 0.0 2.1 2 0 0 2 2 2 1 DNA repair protein REV1 C-terminal domain DUF4646 PF15496.6 ETO13699.1 - 0.035 14.7 0.4 7.6 7.2 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4646) DEAD PF00270.29 ETO13701.1 - 6.2e-48 162.9 0.1 2.1e-46 157.9 0.0 2.8 3 0 0 3 3 3 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO13701.1 - 2.7e-29 101.8 0.1 5e-28 97.7 0.1 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO13701.1 - 0.00031 20.8 0.0 0.0028 17.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Exo70 PF03081.15 ETO13702.1 - 1.1e-49 169.5 19.3 2.3e-48 165.2 9.8 3.8 4 0 0 4 4 4 2 Exo70 exocyst complex subunit Pyr_redox_2 PF07992.14 ETO13703.1 - 4.2e-24 85.3 0.0 9.7e-24 84.1 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO13703.1 - 8.4e-17 61.5 0.1 3.1e-16 59.7 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO13703.1 - 7e-08 32.1 9.3 0.00012 21.4 0.0 3.0 3 1 1 4 4 4 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ETO13703.1 - 0.01 16.2 0.1 0.042 14.3 0.0 2.0 2 1 0 2 2 2 0 Putative NAD(P)-binding HI0933_like PF03486.14 ETO13703.1 - 0.015 14.0 0.9 0.064 12.0 0.0 2.3 3 0 0 3 3 3 0 HI0933-like protein Shikimate_DH PF01488.20 ETO13703.1 - 0.025 14.6 0.4 0.53 10.4 0.0 2.6 3 0 0 3 3 3 0 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 ETO13703.1 - 0.03 13.5 0.2 1.4 8.0 0.0 2.5 2 1 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) GIDA PF01134.22 ETO13703.1 - 0.19 10.8 3.1 0.6 9.1 0.2 2.8 2 2 1 3 3 3 0 Glucose inhibited division protein A LRR_9 PF14580.6 ETO13704.1 - 2.7e-13 49.8 4.3 4.4e-13 49.1 4.3 1.3 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ETO13704.1 - 1e-07 32.2 28.4 0.0012 19.1 3.6 3.8 1 1 1 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO13704.1 - 0.0002 21.0 19.3 0.011 15.4 8.6 3.1 1 1 0 2 2 2 2 Leucine rich repeat U79_P34 PF03064.16 ETO13704.1 - 0.005 16.2 0.6 0.0077 15.6 0.6 1.3 1 0 0 1 1 1 1 HSV U79 / HCMV P34 LRR_6 PF13516.6 ETO13704.1 - 0.87 9.8 11.4 11 6.4 0.1 5.0 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 ETO13704.1 - 1.4 9.7 14.8 90 4.2 0.0 4.7 2 1 0 2 2 2 0 Leucine Rich Repeat Acetyltransf_7 PF13508.7 ETO13706.1 - 3.3e-06 27.4 0.0 6.9e-06 26.4 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO13706.1 - 2.6e-05 24.4 0.0 4.6e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO13706.1 - 4e-05 23.6 0.0 5.9e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO13706.1 - 0.0079 16.1 0.0 0.017 15.1 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein SAM_3 PF18016.1 ETO13706.1 - 0.11 12.3 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) EzrA PF06160.12 ETO13708.1 - 9.8e-07 27.3 1.2 9.8e-07 27.3 1.2 3.0 3 0 0 3 3 3 1 Septation ring formation regulator, EzrA HOOK PF05622.12 ETO13708.1 - 0.00022 19.5 1.2 0.00022 19.5 1.2 2.6 2 1 1 3 3 2 1 HOOK protein CENP-H PF05837.12 ETO13708.1 - 0.0065 16.9 3.6 0.0065 16.9 3.6 3.8 2 1 2 4 4 4 1 Centromere protein H (CENP-H) MCD_N PF17408.2 ETO13708.1 - 0.0077 16.3 0.2 0.0077 16.3 0.2 2.5 4 0 0 4 4 4 1 Malonyl-CoA decarboxylase N-terminal domain Frag1 PF10277.9 ETO13708.1 - 0.014 15.0 7.9 0.021 14.4 7.9 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family DUF1664 PF07889.12 ETO13708.1 - 0.023 14.7 3.2 0.023 14.7 3.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Hom_end PF05204.14 ETO13708.1 - 0.4 10.9 5.0 0.43 10.8 1.6 2.3 2 0 0 2 2 2 0 Homing endonuclease DivIC PF04977.15 ETO13708.1 - 1.2 8.9 26.5 0.93 9.3 0.7 4.8 3 2 1 4 4 4 0 Septum formation initiator NPV_P10 PF05531.12 ETO13708.1 - 1.3 9.6 24.7 1.8 9.1 0.2 4.9 3 2 2 5 5 5 0 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 ETO13708.1 - 1.9 9.0 29.7 0.089 13.2 5.6 4.3 3 3 1 4 4 4 0 Cell division protein ZapB DUF4200 PF13863.6 ETO13708.1 - 4.1 7.8 26.4 43 4.5 15.6 3.8 2 1 0 3 3 3 0 Domain of unknown function (DUF4200) DUF883 PF05957.13 ETO13709.1 - 0.026 15.1 2.8 0.026 15.1 2.8 6.0 2 2 6 8 8 8 0 Bacterial protein of unknown function (DUF883) ADIP PF11559.8 ETO13709.1 - 0.038 14.1 97.6 0.42 10.7 22.8 5.0 1 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding PikAIV_N PF18605.1 ETO13709.1 - 0.84 9.3 8.3 4.5 6.9 0.2 5.0 5 0 0 5 5 5 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain TPR_MLP1_2 PF07926.12 ETO13709.1 - 1.3 9.1 106.5 0.44 10.6 15.9 5.6 1 1 4 5 5 5 0 TPR/MLP1/MLP2-like protein DUF745 PF05335.13 ETO13710.1 - 0.021 14.6 2.4 0.029 14.1 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Antimicrobial19 PF08225.11 ETO13710.1 - 0.15 11.7 1.1 0.61 9.7 1.1 2.0 1 1 0 1 1 1 0 Pseudin antimicrobial peptide GIT_CC PF16559.5 ETO13710.1 - 0.16 11.8 5.6 0.082 12.8 1.7 2.1 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor FlxA PF14282.6 ETO13710.1 - 0.22 11.6 7.0 0.61 10.1 7.1 1.8 1 1 0 1 1 1 0 FlxA-like protein OmpH PF03938.14 ETO13710.1 - 0.45 10.9 6.2 0.64 10.4 6.2 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Exonuc_VII_L PF02601.15 ETO13710.1 - 0.47 10.0 4.1 0.51 9.9 4.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 ETO13710.1 - 0.93 8.8 8.6 1.1 8.5 8.6 1.1 1 0 0 1 1 1 0 FAM76 protein Reticulon PF02453.17 ETO13711.1 - 0.013 15.4 0.7 0.023 14.6 0.7 1.4 1 0 0 1 1 1 0 Reticulon PX PF00787.24 ETO13711.1 - 0.032 14.2 6.6 0.31 11.1 4.0 3.3 2 1 0 2 2 2 0 PX domain WD40 PF00400.32 ETO13712.1 - 2.7e-72 236.9 37.7 5.1e-08 33.5 0.0 14.0 13 2 0 13 13 13 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13712.1 - 3.1e-22 78.7 8.7 0.0048 17.2 0.0 9.0 3 3 3 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide PF00805.22 ETO13712.1 - 1.5e-08 34.1 5.6 3.6e-08 32.9 5.6 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) NACHT PF05729.12 ETO13712.1 - 4.4e-08 33.2 0.0 1.8e-07 31.3 0.0 2.0 2 0 0 2 2 2 1 NACHT domain Pentapeptide_4 PF13599.6 ETO13712.1 - 2.6e-06 27.5 0.7 7.4e-06 26.0 0.7 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO13712.1 - 0.00081 19.5 0.9 0.0021 18.2 0.9 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO13712.1 - 0.00091 19.8 1.0 0.012 16.1 0.0 3.1 3 0 0 3 3 3 1 AAA domain PD40 PF07676.12 ETO13712.1 - 0.00092 19.1 1.4 2.2 8.3 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat AAA_22 PF13401.6 ETO13712.1 - 0.003 17.9 0.0 0.0092 16.3 0.0 1.9 1 0 0 1 1 1 1 AAA domain TniB PF05621.11 ETO13712.1 - 0.037 13.4 0.3 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 Bacterial TniB protein RNA_helicase PF00910.22 ETO13712.1 - 0.072 13.5 3.4 0.27 11.6 0.1 3.7 4 1 0 4 4 4 0 RNA helicase DUF5570 PF17731.1 ETO13712.1 - 0.081 13.0 5.1 14 5.8 0.0 4.9 5 1 0 5 5 4 0 Family of unknown function (DUF5570) TPR_12 PF13424.6 ETO13713.1 - 1.2e-25 89.5 16.9 4.8e-09 36.4 1.1 3.9 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO13713.1 - 3.9e-20 71.1 0.0 3e-07 30.1 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13713.1 - 2e-10 40.0 19.2 4.4e-06 26.3 0.1 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO13713.1 - 2.7e-10 39.6 5.3 0.0058 16.6 0.0 5.6 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13713.1 - 1.1e-09 37.7 21.2 0.0015 18.6 0.2 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13713.1 - 6.9e-09 35.2 16.2 0.00089 19.2 0.1 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO13713.1 - 0.0067 17.0 6.0 15 6.5 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13713.1 - 0.053 14.4 0.0 11 7.2 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO13713.1 - 1.1 9.0 8.9 6.4 6.5 0.2 4.5 4 1 1 5 5 5 0 TPR repeat TPR_17 PF13431.6 ETO13713.1 - 2 9.0 14.7 44 4.8 0.5 5.0 4 1 1 5 5 5 0 Tetratricopeptide repeat Kelch_4 PF13418.6 ETO13714.1 - 1.3e-05 25.1 0.8 5.4e-05 23.1 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO13714.1 - 0.0004 20.6 1.6 0.28 11.5 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO13714.1 - 0.0097 15.9 0.7 0.75 9.8 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO13714.1 - 0.027 14.5 0.7 11 6.2 0.0 3.7 4 0 0 4 4 4 0 Kelch motif HHH_8 PF14716.6 ETO13715.1 - 0.084 13.3 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Helix-hairpin-helix domain US10 PF17617.2 ETO13716.1 - 0.017 15.2 0.0 0.023 14.8 0.0 1.3 1 0 0 1 1 1 0 Viral unique short region 10 zf-RING_2 PF13639.6 ETO13717.1 - 4e-07 30.3 10.1 4e-07 30.3 10.1 2.6 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_3 PF13920.6 ETO13717.1 - 1.1e-06 28.3 6.1 1.1e-06 28.3 6.1 2.4 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO13717.1 - 1.4e-06 28.0 9.7 1.4e-06 28.0 9.7 2.1 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO13717.1 - 3.7e-06 27.1 7.3 1.1e-05 25.6 7.3 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETO13717.1 - 7.1e-06 25.8 11.3 2.1e-05 24.3 11.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO13717.1 - 4.8e-05 23.0 3.0 4.8e-05 23.0 3.0 2.9 3 0 0 3 3 3 1 RING-like zinc finger Prok-RING_4 PF14447.6 ETO13717.1 - 7.6e-05 22.5 8.4 0.00021 21.1 8.4 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETO13717.1 - 0.001 19.0 3.7 0.0027 17.7 3.7 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_5 PF14634.6 ETO13717.1 - 0.0022 17.9 7.4 0.0022 17.9 7.4 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO13717.1 - 0.017 15.1 7.4 0.017 15.1 7.4 2.3 2 0 0 2 2 1 0 RING-type zinc-finger Mito_carr PF00153.27 ETO13717.1 - 0.052 13.5 2.5 0.98 9.4 0.0 3.5 4 1 0 4 4 4 0 Mitochondrial carrier protein EF-hand_1 PF00036.32 ETO13718.1 - 2.4e-32 108.0 27.0 4.4e-09 35.3 1.0 4.5 4 1 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO13718.1 - 1.8e-26 92.3 16.0 7.6e-14 51.9 3.9 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO13718.1 - 5.8e-24 82.5 25.2 9.7e-09 34.3 1.6 4.9 4 1 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 ETO13718.1 - 4.4e-23 79.2 20.5 2.4e-07 30.2 0.6 5.1 4 2 2 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 ETO13718.1 - 1.1e-21 76.4 19.8 2.2e-14 53.0 4.9 3.1 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 ETO13718.1 - 2.2e-12 47.1 1.8 1.2e-05 25.6 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO13718.1 - 1.3e-08 35.2 3.7 0.001 19.4 0.1 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO13718.1 - 2.6e-08 33.8 11.1 0.00012 22.0 0.8 3.0 1 1 1 2 2 2 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 ETO13718.1 - 1.7e-05 24.8 6.1 0.033 14.2 0.0 3.0 3 1 0 3 3 3 2 Tellurite resistance protein TerB Dockerin_1 PF00404.18 ETO13718.1 - 3.7e-05 23.8 7.7 0.016 15.4 1.6 3.6 1 1 3 4 4 4 3 Dockerin type I domain Caleosin PF05042.13 ETO13718.1 - 4.5e-05 23.4 4.3 0.11 12.4 0.0 3.7 1 1 3 4 4 4 2 Caleosin related protein EF-hand_14 PF17959.1 ETO13718.1 - 8.5e-05 22.8 3.4 0.015 15.6 0.1 2.7 2 1 1 3 3 3 2 EF-hand domain SurA_N_2 PF13623.6 ETO13718.1 - 0.00038 20.3 5.2 0.29 11.0 0.9 2.8 1 1 1 2 2 2 2 SurA N-terminal domain EF-hand_11 PF08976.11 ETO13718.1 - 0.00045 21.1 0.1 0.25 12.2 0.0 2.3 1 1 1 2 2 2 1 EF-hand domain Utp21 PF04192.12 ETO13718.1 - 0.0058 16.2 1.9 0.0075 15.8 1.9 1.2 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain DUF3349 PF11829.8 ETO13718.1 - 0.012 16.4 0.8 1.7 9.5 0.1 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) DUF1456 PF07308.13 ETO13718.1 - 0.024 14.9 4.0 0.5 10.7 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) VbhA PF18495.1 ETO13718.1 - 0.035 14.0 2.1 49 3.9 0.0 4.5 4 2 1 5 5 5 0 Antitoxin VbhA ApbA_C PF08546.11 ETO13718.1 - 0.09 13.0 0.2 6.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA C terminal EF-hand_10 PF14788.6 ETO13718.1 - 0.12 12.3 6.2 0.12 12.2 1.0 2.5 2 0 0 2 2 2 0 EF hand VCBS PF13517.6 ETO13718.1 - 1.7 9.3 10.7 21 5.8 0.1 4.0 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella MKRN1_C PF15815.5 ETO13718.1 - 2.6 8.5 7.1 1 9.8 0.8 2.3 1 1 0 2 2 2 0 E3 ubiquitin-protein ligase makorin-1, C-terminal DUF5109 PF17134.4 ETO13718.1 - 4 7.4 5.4 9.4 6.2 0.2 3.3 1 1 3 4 4 4 0 Domain of unknown function (DUF5109) Ig_4 PF16680.5 ETO13720.1 - 0.073 13.3 0.1 0.16 12.3 0.1 1.6 1 1 0 1 1 1 0 T-cell surface glycoprotein CD3 delta chain Ig_5 PF16681.5 ETO13720.1 - 0.13 12.7 1.2 1.9 9.0 0.1 2.7 1 1 2 3 3 3 0 Ig-like domain on T-cell surface glycoprotein CD3 epsilon chain DUF2457 PF10446.9 ETO13721.1 - 0.012 14.8 13.4 0.015 14.4 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Menin PF05053.13 ETO13721.1 - 1.5 7.1 14.2 1.9 6.7 14.2 1.1 1 0 0 1 1 1 0 Menin Dapper PF15268.6 ETO13721.1 - 2.7 6.8 12.7 2.8 6.7 12.7 1.0 1 0 0 1 1 1 0 Dapper Striatin PF08232.12 ETO13721.1 - 2.7 8.6 9.8 4.3 7.9 9.8 1.4 1 0 0 1 1 1 0 Striatin family Presenilin PF01080.17 ETO13721.1 - 8.7 5.0 11.7 11 4.7 11.7 1.2 1 0 0 1 1 1 0 Presenilin DUF4699 PF15770.5 ETO13722.1 - 0.3 10.8 13.9 0.39 10.4 13.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4699) Menin PF05053.13 ETO13722.1 - 2.9 6.1 5.8 3.8 5.7 5.8 1.1 1 0 0 1 1 1 0 Menin WD40 PF00400.32 ETO13723.1 - 0.0036 18.1 0.0 0.007 17.2 0.0 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat CAC1F_C PF16885.5 ETO13723.1 - 0.016 14.9 19.2 0.02 14.6 19.2 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term PI3K_1B_p101 PF10486.9 ETO13723.1 - 0.048 11.4 14.3 0.074 10.8 14.3 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Peptidase_S64 PF08192.11 ETO13723.1 - 0.73 8.3 14.8 0.85 8.0 14.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 DNA_pol_phi PF04931.13 ETO13723.1 - 1.9 6.5 32.1 0.24 9.4 9.7 2.0 2 0 0 2 2 2 0 DNA polymerase phi PTPRCAP PF15713.5 ETO13723.1 - 3.8 7.8 31.6 4.6 7.5 12.2 2.2 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF5445 PF17520.2 ETO13725.1 - 0.4 10.6 2.2 0.71 9.8 2.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5445) UPF0542 PF15086.6 ETO13728.1 - 0.036 14.0 2.7 0.12 12.3 2.7 1.9 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 DUF2852 PF11014.8 ETO13728.1 - 2 8.6 4.6 0.49 10.5 0.1 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF2852) APG6_N PF17675.1 ETO13728.1 - 8.5 6.9 13.0 0.057 13.9 2.9 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region AAA PF00004.29 ETO13729.1 - 1.9e-41 141.6 0.2 8.9e-30 103.8 0.1 2.6 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO13729.1 - 7.8e-06 26.2 2.4 0.0023 18.2 0.9 3.5 2 1 0 2 2 2 1 AAA domain AAA_lid_3 PF17862.1 ETO13729.1 - 9.2e-06 25.4 0.0 2.4e-05 24.1 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 ETO13729.1 - 2.1e-05 23.9 0.0 0.008 15.4 0.0 2.5 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_18 PF13238.6 ETO13729.1 - 2.5e-05 24.8 0.0 0.0044 17.6 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO13729.1 - 8.8e-05 22.9 0.0 0.0028 18.1 0.0 2.7 2 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ETO13729.1 - 0.00011 22.5 0.0 0.049 14.0 0.0 2.8 2 0 0 2 2 2 1 RNA helicase IstB_IS21 PF01695.17 ETO13729.1 - 0.00013 21.8 0.0 0.0061 16.3 0.0 2.6 2 0 0 2 2 2 1 IstB-like ATP binding protein TsaE PF02367.17 ETO13729.1 - 0.00013 21.9 0.0 0.21 11.6 0.0 2.9 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 ETO13729.1 - 0.00046 20.2 0.5 0.0016 18.5 0.1 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETO13729.1 - 0.0017 17.8 0.0 0.003 17.0 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 ETO13729.1 - 0.0024 17.6 0.3 0.0067 16.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain AAA_2 PF07724.14 ETO13729.1 - 0.0034 17.5 0.1 0.014 15.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ETO13729.1 - 0.0039 17.3 0.0 0.061 13.5 0.0 2.3 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO13729.1 - 0.0054 17.3 0.8 0.042 14.4 0.1 2.9 3 1 0 3 3 3 1 ABC transporter AAA_7 PF12775.7 ETO13729.1 - 0.0062 16.1 0.0 0.018 14.6 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region NACHT PF05729.12 ETO13729.1 - 0.007 16.3 0.0 0.32 10.9 0.0 2.8 2 1 0 3 3 3 1 NACHT domain RuvB_N PF05496.12 ETO13729.1 - 0.0084 15.9 0.1 0.04 13.7 0.1 2.1 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 ETO13729.1 - 0.015 15.0 0.0 0.043 13.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ETO13729.1 - 0.018 14.6 0.1 0.49 9.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETO13729.1 - 0.058 13.7 1.8 0.48 10.7 1.2 2.7 2 1 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 ETO13729.1 - 0.064 13.0 0.0 0.23 11.1 0.0 1.9 1 1 0 1 1 1 0 Sigma-54 interaction domain Rad17 PF03215.15 ETO13729.1 - 0.075 13.0 0.5 4.3 7.2 0.1 3.5 2 2 0 3 3 3 0 Rad17 P-loop domain ResIII PF04851.15 ETO13729.1 - 0.081 12.9 0.0 0.51 10.3 0.0 2.3 2 1 0 2 2 2 0 Type III restriction enzyme, res subunit AAA_28 PF13521.6 ETO13729.1 - 0.085 13.1 0.0 0.3 11.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ETO13729.1 - 0.085 11.9 0.1 0.25 10.4 0.0 1.8 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 DUF4261 PF14080.6 ETO13729.1 - 0.1 12.8 1.0 0.19 11.9 0.1 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4261) TniB PF05621.11 ETO13729.1 - 0.18 11.2 2.5 9.1 5.6 1.4 2.9 2 1 0 2 2 2 0 Bacterial TniB protein ATPase_2 PF01637.18 ETO13729.1 - 0.67 9.8 7.6 19 5.1 0.0 3.8 3 1 1 4 4 4 0 ATPase domain predominantly from Archaea RRP36 PF06102.12 ETO13730.1 - 0.57 10.1 8.5 0.77 9.7 8.5 1.2 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 BUD22 PF09073.10 ETO13731.1 - 7.8 5.7 56.1 0.039 13.3 43.4 2.2 2 0 0 2 2 2 0 BUD22 Cation_efflux PF01545.21 ETO13733.1 - 1.9e-12 47.3 25.6 1.9e-10 40.8 25.6 3.2 1 1 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETO13733.1 - 9.1e-08 32.1 1.1 1.8e-07 31.2 1.1 1.5 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter TRAPPC-Trs85 PF12739.7 ETO13733.1 - 0.021 13.8 0.1 0.03 13.3 0.1 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit UL42 PF17638.2 ETO13733.1 - 0.48 10.4 2.3 2.2 8.3 0.2 2.5 2 1 0 2 2 2 0 HCMV UL42 Phi29_Phage_SSB PF17427.2 ETO13734.1 - 0.023 14.9 4.1 0.039 14.1 4.1 1.4 1 0 0 1 1 1 0 Phage Single-stranded DNA-binding protein CstA PF02554.14 ETO13734.1 - 0.094 11.6 19.8 0.57 9.0 0.4 2.0 2 0 0 2 2 2 0 Carbon starvation protein CstA DUF3916 PF13079.6 ETO13734.1 - 0.15 12.0 1.3 0.22 11.4 0.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3916) Med13_C PF06333.12 ETO13735.1 - 0.38 10.0 7.8 0.57 9.4 7.8 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain DUF2547 PF10818.8 ETO13735.1 - 5.2 8.1 7.0 4.8 8.2 0.6 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2547) Nexin_C PF08628.12 ETO13736.1 - 1.9e-19 70.3 0.2 1.9e-19 70.3 0.2 3.6 3 1 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 ETO13736.1 - 3.2e-05 23.9 0.1 0.00013 21.9 0.1 2.1 1 0 0 1 1 1 1 PX domain PXA PF02194.15 ETO13737.1 - 1.3e-09 38.3 0.0 1.3e-09 38.3 0.0 2.4 3 1 0 3 3 3 1 PXA domain PXA PF02194.15 ETO13738.1 - 3.1e-07 30.5 0.4 4.7e-07 30.0 0.4 1.2 1 0 0 1 1 1 1 PXA domain Hexose_dehydrat PF03559.14 ETO13738.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase CDC27 PF09507.10 ETO13739.1 - 0.15 11.4 39.1 0.2 11.0 39.1 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ank_4 PF13637.6 ETO13740.1 - 1.5e-10 41.4 1.4 6.4e-05 23.4 0.3 2.9 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO13740.1 - 1.3e-08 35.3 0.2 2.5e-08 34.4 0.2 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO13740.1 - 8.9e-08 32.3 0.6 7.9e-06 26.0 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO13740.1 - 0.0038 17.6 0.8 6.6 7.7 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETO13740.1 - 0.015 15.7 2.1 1.1 9.8 0.1 2.4 2 0 0 2 2 2 0 Ankyrin repeat Caldesmon PF02029.15 ETO13740.1 - 0.18 10.5 60.7 0.24 10.1 60.7 1.1 1 0 0 1 1 1 0 Caldesmon FPL PF09758.9 ETO13741.1 - 2.1e-41 141.4 9.6 3.9e-41 140.5 9.6 1.5 1 0 0 1 1 1 1 Uncharacterised conserved protein PRR18 PF15671.5 ETO13741.1 - 0.65 9.8 2.3 0.91 9.4 2.3 1.1 1 0 0 1 1 1 0 Proline-rich protein family 18 SelP_N PF04592.14 ETO13742.1 - 0.86 9.0 22.9 0.025 14.0 15.2 2.0 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Striatin PF08232.12 ETO13742.1 - 4.4 7.9 16.5 0.64 10.6 4.0 2.2 2 0 0 2 2 2 0 Striatin family Neur_chan_memb PF02932.16 ETO13742.1 - 9.6 6.2 7.2 17 5.4 4.1 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Pex2_Pex12 PF04757.14 ETO13744.1 - 8.8e-25 87.6 8.1 1.3e-24 87.1 8.1 1.2 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-RING_2 PF13639.6 ETO13744.1 - 2.1e-06 28.0 19.3 5.2e-06 26.7 19.3 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ETO13744.1 - 2.2e-06 27.4 15.3 4.2e-06 26.5 15.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO13744.1 - 0.00054 19.7 18.4 0.0014 18.4 18.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO13744.1 - 0.0006 19.7 14.7 0.0014 18.6 14.7 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO13744.1 - 0.00069 19.4 18.3 0.002 18.0 18.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO13744.1 - 0.00073 19.3 15.2 0.0014 18.4 15.2 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ETO13744.1 - 0.0032 17.7 14.4 0.0088 16.3 14.4 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ETO13744.1 - 0.083 13.1 17.5 0.35 11.1 17.5 2.2 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING U-box PF04564.15 ETO13744.1 - 0.084 13.1 0.0 0.17 12.1 0.0 1.5 1 0 0 1 1 1 0 U-box domain zf-RING_10 PF16685.5 ETO13744.1 - 4.3 7.5 12.7 4.6 7.4 11.2 1.9 2 0 0 2 2 2 0 zinc RING finger of MSL2 G-alpha PF00503.20 ETO13745.1 - 1.2e-85 287.8 9.2 4.1e-84 282.8 9.2 2.0 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO13745.1 - 3e-11 43.1 1.1 1.2e-05 24.8 0.0 3.4 3 0 0 3 3 3 3 ADP-ribosylation factor family Pox_A32 PF04665.12 ETO13745.1 - 0.0027 17.2 0.6 0.028 13.9 0.1 2.5 3 0 0 3 3 3 1 Poxvirus A32 protein Roc PF08477.13 ETO13745.1 - 0.0029 17.8 0.3 0.78 10.0 0.1 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ETO13745.1 - 0.0039 16.6 7.4 0.0064 15.9 0.2 2.6 3 0 0 3 3 3 1 Gtr1/RagA G protein conserved region SMC_N PF02463.19 ETO13745.1 - 0.01 15.3 0.0 0.02 14.3 0.0 1.7 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain ATP_bind_1 PF03029.17 ETO13745.1 - 0.018 14.8 0.6 3 7.5 0.1 2.5 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 ETO13745.1 - 0.021 15.4 0.1 0.059 13.9 0.1 2.0 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO13745.1 - 0.024 15.1 0.4 0.045 14.3 0.4 1.4 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 ETO13745.1 - 0.033 13.6 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ETO13745.1 - 0.066 13.6 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ETO13745.1 - 0.21 11.5 0.7 0.54 10.2 0.4 2.1 2 1 0 2 2 2 0 NACHT domain Ras PF00071.22 ETO13745.1 - 0.25 10.9 1.8 32 4.1 0.0 3.5 3 1 0 3 3 3 0 Ras family DUF3043 PF11241.8 ETO13747.1 - 0.47 10.5 3.5 0.81 9.7 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3043) Apc15p PF05841.11 ETO13748.1 - 0.92 10.3 11.1 0.23 12.3 4.4 2.5 2 0 0 2 2 2 0 Apc15p protein Met_10 PF02475.16 ETO13749.1 - 1.9e-26 93.1 0.0 2.3e-26 92.8 0.0 1.1 1 0 0 1 1 1 1 Met-10+ like-protein MTS PF05175.14 ETO13749.1 - 5.8e-06 26.0 0.0 1.1e-05 25.0 0.0 1.4 2 0 0 2 2 2 1 Methyltransferase small domain tRNA_U5-meth_tr PF05958.11 ETO13749.1 - 0.001 18.1 0.0 0.0014 17.7 0.0 1.2 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase TRM PF02005.16 ETO13749.1 - 0.0025 17.0 0.0 0.003 16.8 0.0 1.1 1 0 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase Cons_hypoth95 PF03602.15 ETO13749.1 - 0.003 17.2 0.0 0.0042 16.8 0.0 1.3 1 1 0 1 1 1 1 Conserved hypothetical protein 95 DNA_methylase PF00145.17 ETO13749.1 - 0.0036 16.7 0.1 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 C-5 cytosine-specific DNA methylase TYW3 PF02676.14 ETO13750.1 - 5.7e-57 192.5 0.1 4.1e-56 189.7 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase TYW3 DUF4484 PF14831.6 ETO13750.1 - 0.0012 19.0 2.1 0.0027 17.8 2.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) Herpes_UL55 PF04537.12 ETO13750.1 - 0.019 15.0 0.0 0.049 13.7 0.0 1.6 1 0 0 1 1 1 0 Herpesvirus UL55 protein TMEM51 PF15345.6 ETO13750.1 - 0.5 10.2 6.9 0.11 12.4 2.5 2.0 2 1 0 2 2 2 0 Transmembrane protein 51 zf-C3HC4_2 PF13923.6 ETO13751.1 - 2.2e-10 40.2 17.7 5.5e-10 38.9 11.4 3.0 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO13751.1 - 3.7e-10 39.5 15.2 2.1e-08 33.9 10.1 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO13751.1 - 1e-08 35.0 5.4 1e-08 35.0 5.4 3.4 3 1 0 3 3 3 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO13751.1 - 1.6e-08 34.8 18.8 2.2e-07 31.1 11.4 3.4 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 ETO13751.1 - 2.3e-08 33.7 11.8 2.3e-08 33.7 11.8 3.1 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO13751.1 - 5.4e-08 32.7 13.1 4.5e-07 29.7 9.6 2.8 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO13751.1 - 3.1e-06 26.9 18.9 0.002 17.9 12.8 3.8 2 1 1 3 3 3 3 Prokaryotic RING finger family 4 SAP PF02037.27 ETO13751.1 - 1.5e-05 24.6 0.2 3.9e-05 23.3 0.2 1.8 1 0 0 1 1 1 1 SAP domain zf-WRNIP1_ubi PF18279.1 ETO13751.1 - 1.5e-05 25.3 10.9 0.0015 19.0 0.8 4.2 3 0 0 3 3 3 2 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-C3HC4_4 PF15227.6 ETO13751.1 - 4.5e-05 23.5 12.4 9.2e-05 22.5 8.7 3.1 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ETO13751.1 - 0.00033 20.5 6.6 0.00033 20.5 6.6 1.9 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 ETO13751.1 - 0.0015 18.8 12.8 0.018 15.3 9.5 3.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain UBZ_FAAP20 PF15750.5 ETO13751.1 - 0.0017 18.2 9.0 0.029 14.3 0.4 3.5 3 0 0 3 3 3 2 Ubiquitin-binding zinc-finger U-box PF04564.15 ETO13751.1 - 0.008 16.3 0.2 0.053 13.7 0.1 2.5 2 0 0 2 2 2 1 U-box domain zf-RING_4 PF14570.6 ETO13751.1 - 0.023 14.5 9.7 0.045 13.5 2.5 3.6 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain AD PF09793.9 ETO13751.1 - 0.058 13.5 1.8 0.29 11.3 1.8 2.2 1 0 0 1 1 1 0 Anticodon-binding domain zinc-ribbons_6 PF07191.12 ETO13751.1 - 0.094 12.7 13.0 0.58 10.2 8.3 2.7 2 0 0 2 2 2 0 zinc-ribbons Zn-C2H2_12 PF18112.1 ETO13751.1 - 0.097 13.2 10.4 1.1 9.8 0.3 4.0 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain Sgf11 PF08209.11 ETO13751.1 - 0.12 12.0 7.1 0.29 10.7 0.4 3.5 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-RING_10 PF16685.5 ETO13751.1 - 0.24 11.6 12.1 0.089 12.9 8.4 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 zf-ANAPC11 PF12861.7 ETO13751.1 - 0.68 10.0 6.2 1.7 8.7 4.6 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger RecR PF02132.15 ETO13751.1 - 0.83 9.3 12.9 1.2 8.7 2.7 3.5 3 0 0 3 3 3 0 RecR protein DNA_ligase_ZBD PF03119.16 ETO13751.1 - 0.99 9.5 6.1 4.9 7.3 0.1 3.4 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Rad50_zn_hook PF04423.14 ETO13751.1 - 1.3 8.9 14.5 22 5.0 0.5 5.5 5 0 0 5 5 5 0 Rad50 zinc hook motif zf_UBZ PF18439.1 ETO13751.1 - 2.9 7.6 11.7 0.91 9.2 0.2 3.7 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger TRAF6_Z2 PF18048.1 ETO13751.1 - 2.9 8.1 10.7 4.3 7.5 1.2 3.5 3 0 0 3 3 2 0 TNF receptor-associated factor 6 zinc finger 2 DZR PF12773.7 ETO13751.1 - 6.5 6.9 12.7 7.5 6.7 7.5 2.7 2 1 0 2 2 2 0 Double zinc ribbon FAM176 PF14851.6 ETO13751.1 - 7.2 6.3 8.9 21 4.7 2.6 2.5 2 0 0 2 2 2 0 FAM176 family PP2C PF00481.21 ETO13752.1 - 1.2e-33 116.8 0.1 1.8e-18 67.1 0.0 2.3 2 1 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ETO13752.1 - 0.0049 16.5 0.0 0.026 14.2 0.0 2.1 2 1 0 2 2 2 1 Protein phosphatase 2C SpoIIE PF07228.12 ETO13752.1 - 0.032 14.1 0.0 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) Band_7 PF01145.25 ETO13753.1 - 2.1e-11 44.1 8.1 2.1e-11 44.1 8.1 1.5 2 0 0 2 2 2 1 SPFH domain / Band 7 family YdfA_immunity PF12127.8 ETO13753.1 - 0.03 13.4 5.5 0.041 12.9 5.5 1.2 1 0 0 1 1 1 0 SigmaW regulon antibacterial DUF1191 PF06697.12 ETO13753.1 - 0.22 11.3 1.4 14 5.4 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1191) PRP9_N PF16958.5 ETO13753.1 - 1.6 8.8 8.3 0.3 11.1 2.1 2.4 1 1 1 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus TMEM107 PF14995.6 ETO13754.1 - 0.001 19.5 2.3 0.0014 19.0 0.2 2.3 2 0 0 2 2 2 1 Transmembrane protein CCB1 PF12046.8 ETO13754.1 - 0.12 11.7 0.0 0.24 10.7 0.0 1.4 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B Skp1_POZ PF03931.15 ETO13755.1 - 5.9e-06 26.4 0.2 1.6e-05 25.0 0.1 1.8 1 1 1 2 2 2 1 Skp1 family, tetramerisation domain hNIFK_binding PF12196.8 ETO13755.1 - 0.078 12.5 0.6 0.19 11.3 0.6 1.6 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Skp1 PF01466.19 ETO13755.1 - 0.18 12.0 0.5 0.56 10.4 0.2 2.0 2 0 0 2 2 2 0 Skp1 family, dimerisation domain cNMP_binding PF00027.29 ETO13757.1 - 8e-15 54.7 0.0 1.8e-14 53.5 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Tub_N PF16322.5 ETO13757.1 - 0.6 10.5 16.3 0.91 9.9 16.3 1.2 1 0 0 1 1 1 0 Tubby N-terminal CDC45 PF02724.14 ETO13757.1 - 9.2 4.4 12.6 13 3.9 12.6 1.2 1 0 0 1 1 1 0 CDC45-like protein MscS_TM PF12794.7 ETO13758.1 - 0.00011 21.2 1.3 0.00011 21.2 1.3 1.6 2 0 0 2 2 2 1 Mechanosensitive ion channel inner membrane domain 1 DUF4637 PF15470.6 ETO13758.1 - 0.0019 18.0 9.8 0.0019 18.0 9.8 3.3 3 1 2 5 5 5 1 Domain of unknown function (DUF4637) EMC3_TMCO1 PF01956.16 ETO13758.1 - 0.36 10.5 3.3 1 9.1 0.0 2.8 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like BSP_II PF05432.11 ETO13758.1 - 1.8 8.2 52.3 0.65 9.6 18.8 2.8 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) DUF1682 PF07946.14 ETO13758.1 - 7.1 5.7 18.2 0.024 13.9 7.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) Peptidase_M16_C PF05193.21 ETO13759.1 - 6.4e-27 94.7 0.0 8.1e-27 94.4 0.0 1.1 1 0 0 1 1 1 1 Peptidase M16 inactive domain ASFV_p27 PF06556.11 ETO13761.1 - 0.14 12.2 0.1 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 IAP-like protein p27 C-terminus Sarcoglycan_1 PF04790.13 ETO13761.1 - 1.1 8.5 3.7 2.2 7.6 2.0 1.7 1 1 1 2 2 2 0 Sarcoglycan complex subunit protein Nup_retrotrp_bd PF10599.9 ETO13762.1 - 0.99 10.1 13.1 0.4 11.4 10.9 1.5 2 0 0 2 2 2 0 Retro-transposon transporting motif Orf78 PF06024.12 ETO13762.1 - 2.1 8.7 4.6 4 7.8 4.6 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Macoilin PF09726.9 ETO13764.1 - 0.63 8.5 27.8 0.86 8.1 27.8 1.2 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 ETO13764.1 - 7.6 5.6 8.8 9.7 5.3 8.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Porph_ging PF09697.10 ETO13765.1 - 0.24 11.9 1.6 0.38 11.3 0.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) DUF2334 PF10096.9 ETO13766.1 - 0.017 14.8 0.0 0.028 14.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Ribosomal_L5e PF17144.4 ETO13766.1 - 0.17 11.9 0.4 0.27 11.2 0.4 1.3 1 0 0 1 1 1 0 Ribosomal large subunit proteins 60S L5, and 50S L18 WD40 PF00400.32 ETO13768.1 - 7.1e-12 45.7 3.3 3.9e-05 24.3 1.1 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO13768.1 - 0.00025 19.8 0.3 0.075 11.7 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO13768.1 - 0.0012 19.1 0.2 0.046 14.0 0.0 2.6 1 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO13769.1 - 4.6e-25 87.4 13.3 1e-06 29.3 0.9 5.0 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13769.1 - 1.3e-10 41.4 0.5 0.0092 16.3 0.1 4.0 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO13769.1 - 9.4e-08 31.1 0.2 0.23 10.1 0.0 4.0 1 1 2 4 4 4 4 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO13769.1 - 0.017 15.4 0.4 12 6.1 0.1 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) Flu_NP PF00506.18 ETO13770.1 - 0.056 12.1 0.1 0.064 11.9 0.1 1.1 1 0 0 1 1 1 0 Influenza virus nucleoprotein Chorein_N PF12624.7 ETO13772.1 - 8.8e-06 25.8 3.0 0.00029 20.9 0.2 2.4 2 1 0 2 2 2 2 N-terminal region of Chorein or VPS13 WD40 PF00400.32 ETO13773.1 - 2.8e-26 91.2 14.1 3.7e-06 27.5 0.4 5.9 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13773.1 - 3.6e-08 33.6 0.1 1 9.7 0.0 5.4 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO13773.1 - 2.2e-05 23.9 11.0 0.096 12.0 0.2 4.6 1 1 3 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO13773.1 - 0.00036 19.3 1.5 7.4 5.1 0.0 4.4 2 2 3 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO13773.1 - 0.0054 15.5 3.9 0.02 13.7 1.1 2.7 2 1 1 3 3 3 2 Nup133 N terminal like PALB2_WD40 PF16756.5 ETO13773.1 - 0.1 11.5 0.0 11 4.8 0.0 2.4 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Sec23_trunk PF04811.15 ETO13773.1 - 0.11 12.0 0.1 0.3 10.6 0.1 1.8 2 0 0 2 2 2 0 Sec23/Sec24 trunk domain SR-25 PF10500.9 ETO13774.1 - 0.075 12.6 13.1 0.12 11.9 13.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein YAF2_RYBP PF17219.3 ETO13774.1 - 0.1 12.2 0.0 0.27 10.9 0.0 1.7 1 0 0 1 1 1 0 Yaf2/RYBP C-terminal binding motif DUF3446 PF11928.8 ETO13774.1 - 0.12 12.7 11.9 0.077 13.3 8.8 2.1 2 0 0 2 2 2 0 Early growth response N-terminal domain N_BRCA1_IG PF16158.5 ETO13776.1 - 2.5e-24 85.9 0.0 3.6e-24 85.5 0.0 1.2 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene CopC PF04234.12 ETO13776.1 - 0.0061 17.6 0.0 0.47 11.5 0.0 2.1 2 0 0 2 2 2 1 CopC domain DUF3653 PF12375.8 ETO13776.1 - 0.12 12.4 0.0 0.36 11.0 0.0 1.8 1 0 0 1 1 1 0 Phage protein Phytochelatin PF05023.14 ETO13777.1 - 1.3e-10 40.9 0.3 2e-10 40.3 0.3 1.2 1 0 0 1 1 1 1 Phytochelatin synthase RPN2_C PF18004.1 ETO13777.1 - 0.005 16.8 2.9 0.005 16.8 2.9 2.0 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4905 PF16248.5 ETO13777.1 - 0.066 13.1 2.6 0.11 12.5 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4905) FAM176 PF14851.6 ETO13777.1 - 0.1 12.2 10.8 0.89 9.2 5.6 2.3 2 0 0 2 2 2 0 FAM176 family Gar1 PF04410.14 ETO13777.1 - 0.11 12.3 7.6 0.21 11.3 7.6 1.5 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region Eapp_C PF10238.9 ETO13777.1 - 0.13 12.3 8.2 0.075 13.1 2.7 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein Sporozoite_P67 PF05642.11 ETO13777.1 - 0.2 9.7 3.8 0.28 9.2 3.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RR_TM4-6 PF06459.12 ETO13777.1 - 0.41 10.4 13.7 1.7 8.4 5.6 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 HA2 PF04408.23 ETO13777.1 - 0.43 10.9 2.5 1 9.7 0.4 2.2 2 0 0 2 2 2 0 Helicase associated domain (HA2) UPF0239 PF06783.11 ETO13777.1 - 1 9.6 6.8 0.2 11.8 0.7 2.4 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0239) DNA_pol_phi PF04931.13 ETO13777.1 - 1.1 7.3 10.5 1.8 6.6 10.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi XRN_M PF17846.1 ETO13777.1 - 1.2 8.0 10.0 1.9 7.3 4.4 2.0 1 1 1 2 2 2 0 Xrn1 helical domain MCU PF04678.13 ETO13777.1 - 2.6 8.1 7.9 2.7 8.1 1.2 2.7 2 1 1 3 3 3 0 Mitochondrial calcium uniporter Coilin_N PF15862.5 ETO13777.1 - 2.7 7.8 16.0 8.2 6.2 10.7 2.4 2 1 0 2 2 2 0 Coilin N-terminus RPA43_OB PF17875.1 ETO13777.1 - 3.3 8.3 11.2 0.3 11.7 5.3 2.0 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I CPSF100_C PF13299.6 ETO13777.1 - 5.7 7.1 9.0 0.2 11.8 1.3 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S64 PF08192.11 ETO13777.1 - 5.9 5.2 13.1 7.8 4.8 13.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 RNA_pol_Rpc4 PF05132.14 ETO13777.1 - 7.1 7.0 8.1 0.33 11.4 1.3 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 PI3_PI4_kinase PF00454.27 ETO13778.1 - 1.5e-06 28.2 0.0 3.3e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase Dicty_REP PF05086.12 ETO13778.1 - 0.034 12.1 5.9 0.053 11.5 5.9 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 ETO13778.1 - 0.092 10.9 11.7 0.12 10.6 11.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO13778.1 - 0.32 11.0 14.4 0.64 10.0 14.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO13778.1 - 1.2 9.1 21.7 2.1 8.4 21.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein PI3K_rbd PF00794.18 ETO13780.1 - 0.0061 16.7 0.2 0.018 15.2 0.1 1.8 1 1 0 1 1 1 1 PI3-kinase family, ras-binding domain Dicty_REP PF05086.12 ETO13782.1 - 2.7 5.9 4.0 4 5.3 4.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TFIIF_alpha PF05793.12 ETO13783.1 - 0.32 9.5 2.0 0.37 9.3 2.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SR-25 PF10500.9 ETO13783.1 - 3.1 7.3 7.1 4.6 6.8 7.1 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Ferlin_C PF16165.5 ETO13784.1 - 0.49 10.3 5.7 0.81 9.6 5.7 1.3 1 0 0 1 1 1 0 Ferlin C-terminus DUF3915 PF13054.6 ETO13784.1 - 0.89 9.5 5.3 1.8 8.6 5.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF789 PF05623.12 ETO13784.1 - 1.5 8.4 7.3 2.2 7.9 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) CDC45 PF02724.14 ETO13784.1 - 1.5 7.0 12.5 2.1 6.6 12.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Sec62 PF03839.16 ETO13784.1 - 1.9 7.9 9.9 3 7.3 9.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 SOBP PF15279.6 ETO13784.1 - 3.3 8.3 14.1 4.2 7.9 14.1 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein FAM176 PF14851.6 ETO13784.1 - 4.1 7.1 6.7 7.3 6.2 6.7 1.4 1 0 0 1 1 1 0 FAM176 family Vfa1 PF08432.10 ETO13784.1 - 8.4 6.7 19.4 13 6.1 19.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Adap_comp_sub PF00928.21 ETO13789.1 - 1.1e-32 113.5 0.0 4.6e-29 101.6 0.0 2.1 2 0 0 2 2 2 2 Adaptor complexes medium subunit family Pkinase PF00069.25 ETO13790.1 - 5.6e-27 94.8 0.0 2.5e-19 69.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13790.1 - 1.6e-05 24.4 0.0 6.2e-05 22.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO13790.1 - 0.0059 16.0 0.2 0.009 15.4 0.2 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO13790.1 - 0.013 15.4 0.0 0.021 14.7 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ribonuc_L-PSP PF01042.21 ETO13792.1 - 6.3e-15 55.3 0.0 1.1e-08 35.1 0.0 2.3 2 0 0 2 2 2 2 Endoribonuclease L-PSP NST1 PF13945.6 ETO13792.1 - 0.00046 20.3 4.4 0.0009 19.4 4.4 1.4 1 0 0 1 1 1 1 Salt tolerance down-regulator YL1 PF05764.13 ETO13792.1 - 0.026 14.7 7.0 0.041 14.0 7.0 1.2 1 0 0 1 1 1 0 YL1 nuclear protein DUF4484 PF14831.6 ETO13792.1 - 0.26 11.3 2.2 0.47 10.4 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) Peptidase_U57 PF05582.12 ETO13792.1 - 0.6 9.3 5.1 1.2 8.3 2.9 2.0 2 0 0 2 2 2 0 YabG peptidase U57 Diphthami_syn_2 PF01902.17 ETO13793.1 - 6.4e-08 32.4 0.0 7.1e-08 32.2 0.0 1.1 1 0 0 1 1 1 1 Diphthamide synthase DUF3784 PF12650.7 ETO13795.1 - 0.0097 16.1 1.1 0.0097 16.1 1.1 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF3784) DUF3522 PF12036.8 ETO13795.1 - 0.013 15.8 2.2 0.41 10.9 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3522) DcuA_DcuB PF03605.14 ETO13795.1 - 0.52 9.1 1.8 0.52 9.1 0.3 1.6 1 1 0 2 2 2 0 Anaerobic c4-dicarboxylate membrane transporter Renin_r PF07850.14 ETO13795.1 - 4.4 8.0 6.3 14 6.3 0.8 2.4 1 1 1 2 2 2 0 Renin receptor-like protein DUF2585 PF10755.9 ETO13798.1 - 0.02 14.6 0.9 0.059 13.1 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2585) DUF2809 PF10990.8 ETO13798.1 - 0.062 14.0 0.6 0.13 12.9 0.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2809) CitMHS PF03600.16 ETO13799.1 - 1.2 8.2 12.4 4.7 6.3 12.4 1.9 1 1 0 1 1 1 0 Citrate transporter TMEMspv1-c74-12 PF11044.8 ETO13799.1 - 7.8 6.6 6.8 0.46 10.5 0.3 2.5 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein CF222 PF15661.5 ETO13800.1 - 0.86 8.4 12.5 0.96 8.3 12.5 1.0 1 0 0 1 1 1 0 C6orf222, uncharacterised family WD40 PF00400.32 ETO13802.1 - 4.5e-08 33.6 5.3 3.7e-06 27.5 0.6 2.9 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO13802.1 - 0.1 11.2 0.2 0.45 9.1 0.1 1.8 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Trypan_PARP PF05887.11 ETO13803.1 - 0.011 15.7 1.2 0.011 15.7 1.2 4.4 3 1 1 4 4 4 0 Procyclic acidic repetitive protein (PARP) DUF5106 PF17127.4 ETO13804.1 - 0.02 15.2 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5106) Alpha_L_fucos PF01120.17 ETO13804.1 - 0.19 11.2 1.8 0.25 10.8 1.8 1.0 1 0 0 1 1 1 0 Alpha-L-fucosidase YL1 PF05764.13 ETO13805.1 - 5.4e-05 23.4 27.6 5.4e-05 23.4 27.6 2.2 2 0 0 2 2 2 1 YL1 nuclear protein Hid1 PF12722.7 ETO13805.1 - 7.6 4.5 28.8 0.026 12.7 14.8 2.0 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein C2 PF00168.30 ETO13806.1 - 8.6e-06 26.0 0.0 1.2e-05 25.5 0.0 1.3 1 0 0 1 1 1 1 C2 domain B9-C2 PF07162.11 ETO13806.1 - 0.14 12.3 0.0 0.16 12.1 0.0 1.1 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein RGS PF00615.19 ETO13807.1 - 0.0025 18.1 0.7 0.0068 16.7 0.7 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain Vfa1 PF08432.10 ETO13807.1 - 0.01 16.2 1.9 0.01 16.2 1.9 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DARPP-32 PF05395.12 ETO13807.1 - 0.014 15.6 3.0 0.014 15.6 3.0 2.1 2 0 0 2 2 2 0 Protein phosphatase inhibitor 1/DARPP-32 RRN3 PF05327.11 ETO13807.1 - 0.038 12.5 13.2 0.22 10.0 8.4 2.1 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 SID-1_RNA_chan PF13965.6 ETO13807.1 - 0.061 11.7 2.1 0.086 11.2 2.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 YL1 PF05764.13 ETO13807.1 - 0.062 13.4 15.1 0.03 14.4 8.4 2.2 2 0 0 2 2 2 0 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 ETO13807.1 - 2.2 7.9 30.1 0.065 13.0 18.0 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF2796 PF10986.8 ETO13807.1 - 4.7 7.1 13.6 1.9 8.4 3.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) Consortin_C PF15281.6 ETO13808.1 - 0.035 14.1 1.5 1 9.4 0.0 2.5 2 0 0 2 2 2 0 Consortin C-terminus FixQ PF05545.11 ETO13808.1 - 2.4 8.2 5.6 2.7 8.0 0.1 3.2 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ DUF2730 PF10805.8 ETO13810.1 - 0.61 10.2 5.3 2.5 8.3 0.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) RasGAP PF00616.19 ETO13811.1 - 0.00044 20.0 2.6 0.00049 19.9 2.6 1.1 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Secretin_N_2 PF07655.13 ETO13811.1 - 0.07 13.7 9.1 0.082 13.5 9.1 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain KilA-N PF04383.13 ETO13811.1 - 0.17 11.7 8.3 0.27 11.1 8.3 1.4 1 1 0 1 1 1 0 KilA-N domain Apis_Csd PF11671.8 ETO13811.1 - 0.28 11.2 12.9 0.31 11.0 12.9 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein Menin PF05053.13 ETO13811.1 - 1.2 7.4 6.3 1.2 7.4 6.3 1.0 1 0 0 1 1 1 0 Menin PGP_phosphatase PF09419.10 ETO13812.1 - 0.00015 21.5 0.2 0.00026 20.6 0.2 1.4 1 0 0 1 1 1 1 Mitochondrial PGP phosphatase GST_N_3 PF13417.6 ETO13812.1 - 0.14 12.6 0.1 0.55 10.7 0.0 1.9 2 0 0 2 2 2 0 Glutathione S-transferase, N-terminal domain PUB PF09409.10 ETO13814.1 - 4.9e-07 29.6 0.7 9.9e-07 28.6 0.7 1.5 1 0 0 1 1 1 1 PUB domain Glycophorin_A PF01102.18 ETO13814.1 - 0.018 15.3 0.1 0.038 14.2 0.1 1.5 1 0 0 1 1 1 0 Glycophorin A Peptidase_C39_2 PF13529.6 ETO13815.1 - 1.1e-07 32.4 1.4 0.0081 16.7 0.0 2.7 2 1 1 3 3 3 2 Peptidase_C39 like family BRK PF07533.16 ETO13815.1 - 0.018 14.6 0.3 7.8 6.2 0.0 2.4 2 0 0 2 2 2 0 BRK domain UQ_con PF00179.26 ETO13816.1 - 1.8e-22 79.5 0.0 3.1e-12 46.3 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme CCSMST1 PF15013.6 ETO13816.1 - 0.018 15.2 1.0 5.5 7.2 0.2 2.5 2 0 0 2 2 2 0 CCSMST1 family Nop14 PF04147.12 ETO13817.1 - 0.13 10.4 19.2 0.18 10.0 19.2 1.2 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ETO13817.1 - 0.2 11.7 17.4 0.32 11.1 17.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein SDA1 PF05285.12 ETO13817.1 - 0.49 9.8 20.8 0.83 9.0 20.8 1.3 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO13817.1 - 0.8 7.9 20.1 1.2 7.3 20.1 1.2 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 ETO13817.1 - 0.87 9.2 25.5 0.11 12.1 17.6 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) TRAP_alpha PF03896.16 ETO13817.1 - 1.2 8.3 10.4 2.2 7.4 10.4 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO13817.1 - 1.3 7.0 23.6 1.9 6.5 23.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Totivirus_coat PF05518.11 ETO13817.1 - 4.5 5.2 6.6 8.1 4.4 6.6 1.4 1 0 0 1 1 1 0 Totivirus coat protein DUF4614 PF15391.6 ETO13817.1 - 9.9 6.1 15.6 4.1 7.4 10.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Sigma70_ner PF04546.13 ETO13819.1 - 0.0093 15.9 0.3 0.013 15.4 0.3 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region FAM176 PF14851.6 ETO13819.1 - 0.056 13.1 0.2 0.09 12.4 0.2 1.3 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 ETO13819.1 - 0.086 10.9 0.8 0.11 10.6 0.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PBP1_TM PF14812.6 ETO13819.1 - 0.56 10.6 8.1 1.1 9.6 8.1 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO13819.1 - 1.4 8.2 8.6 1.9 7.7 8.6 1.1 1 0 0 1 1 1 0 NOA36 protein Ycf70 PF17382.2 ETO13820.1 - 0.15 12.5 0.0 0.31 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized Ycf70-like CEND1 PF15677.5 ETO13821.1 - 0.094 13.3 0.1 0.094 13.3 0.1 2.0 2 1 0 2 2 2 0 Cell cycle exit and neuronal differentiation protein 1 TFIIA PF03153.13 ETO13821.1 - 0.75 9.7 18.7 0.86 9.5 18.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RRN3 PF05327.11 ETO13821.1 - 2.2 6.7 18.1 2.8 6.4 18.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PPP4R2 PF09184.11 ETO13821.1 - 6.3 6.3 22.8 9.1 5.8 22.8 1.2 1 0 0 1 1 1 0 PPP4R2 SAPS PF04499.15 ETO13821.1 - 7.3 5.3 12.0 8 5.1 12.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4349 PF14257.6 ETO13822.1 - 0.0027 17.2 4.6 0.0027 17.2 4.6 1.9 1 1 0 2 2 2 1 Domain of unknown function (DUF4349) STAT_alpha PF01017.20 ETO13822.1 - 0.003 17.5 14.8 0.15 12.0 8.7 2.2 2 0 0 2 2 2 2 STAT protein, all-alpha domain AAA_13 PF13166.6 ETO13822.1 - 0.013 14.2 9.0 0.015 14.0 9.0 1.1 1 0 0 1 1 1 0 AAA domain Spc7 PF08317.11 ETO13822.1 - 0.014 14.3 22.3 0.01 14.8 9.7 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein Laminin_II PF06009.12 ETO13822.1 - 0.067 13.2 10.9 0.064 13.3 2.2 2.5 1 1 1 2 2 2 0 Laminin Domain II Matrilin_ccoil PF10393.9 ETO13822.1 - 0.093 12.6 5.6 0.46 10.4 0.4 3.7 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Fib_alpha PF08702.10 ETO13822.1 - 0.18 11.9 16.4 3.9 7.7 5.4 2.4 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family HAUS2 PF15003.6 ETO13822.1 - 0.29 10.8 11.3 7.3 6.3 7.7 2.9 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 2 DUF3450 PF11932.8 ETO13822.1 - 0.53 9.5 14.3 1.6 8.0 13.4 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO13822.1 - 0.59 10.2 12.2 0.46 10.5 3.4 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 ETO13822.1 - 0.73 8.9 11.8 1.1 8.3 9.6 1.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ACR_tran PF00873.19 ETO13822.1 - 0.76 7.3 3.0 0.85 7.2 3.0 1.1 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Baculo_PEP_C PF04513.12 ETO13822.1 - 0.93 9.5 6.0 12 6.0 5.2 2.8 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Serine_rich PF08824.10 ETO13822.1 - 1.1 9.3 10.7 10 6.1 10.6 2.3 1 1 0 1 1 1 0 Serine rich protein interaction domain KELK PF15796.5 ETO13822.1 - 1.4 9.4 23.1 1.3 9.5 1.6 3.2 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Exonuc_VII_L PF02601.15 ETO13822.1 - 1.7 8.1 16.3 5.3 6.5 16.3 1.8 1 1 0 1 1 1 0 Exonuclease VII, large subunit DUF3552 PF12072.8 ETO13822.1 - 2.2 7.7 20.1 2 7.8 18.4 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Sec2p PF06428.11 ETO13822.1 - 3.2 7.8 18.8 6.2 6.9 9.9 3.3 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p PEARLI-4 PF05278.12 ETO13822.1 - 6 6.4 16.6 1 8.9 5.6 2.4 1 1 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF4407 PF14362.6 ETO13822.1 - 6.2 6.1 7.9 8.9 5.6 7.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YabA PF06156.13 ETO13822.1 - 6.5 7.5 17.2 7.2 7.3 3.0 2.9 1 1 2 3 3 2 0 Initiation control protein YabA TMPIT PF07851.13 ETO13822.1 - 8.6 5.5 17.1 4.8 6.3 7.3 2.1 1 1 1 2 2 2 0 TMPIT-like protein Ribosomal_L44 PF00935.19 ETO13824.1 - 1.2e-27 96.2 11.0 1.2e-27 96.2 11.0 2.1 2 1 1 3 3 3 1 Ribosomal protein L44 Cytochrome_C554 PF13435.6 ETO13824.1 - 0.16 12.9 7.9 0.87 10.5 7.6 2.0 1 1 0 1 1 1 0 Cytochrome c554 and c-prime Cytochrome_C7 PF14522.6 ETO13824.1 - 2.9 8.0 10.9 13 5.9 9.0 2.1 1 1 1 2 2 2 0 Cytochrome c7 and related cytochrome c Ribosomal_S17 PF00366.20 ETO13825.1 - 0.077 13.1 0.0 0.12 12.4 0.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S17 Neisseria_TspB PF05616.13 ETO13825.1 - 0.59 8.5 2.8 0.7 8.3 2.8 1.1 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein SDA1 PF05285.12 ETO13826.1 - 0.0022 17.5 17.4 0.003 17.1 17.4 1.1 1 0 0 1 1 1 1 SDA1 Folliculin PF11704.8 ETO13826.1 - 0.051 13.5 0.7 0.11 12.4 0.7 1.6 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport CDC45 PF02724.14 ETO13826.1 - 0.068 11.5 10.8 0.11 10.7 10.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO13826.1 - 0.3 9.1 12.1 0.46 8.5 12.1 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen POX PF07526.11 ETO13826.1 - 0.77 10.3 0.0 0.77 10.3 0.0 3.3 3 1 0 3 3 3 0 Associated with HOX Vfa1 PF08432.10 ETO13826.1 - 0.89 9.9 11.3 1.7 8.9 11.3 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 BUD22 PF09073.10 ETO13826.1 - 2.4 7.4 19.1 3.3 6.9 19.1 1.1 1 0 0 1 1 1 0 BUD22 Occludin_ELL PF07303.13 ETO13826.1 - 2.4 8.9 11.9 0.22 12.3 5.0 2.5 2 1 0 2 2 2 0 Occludin homology domain Ribosomal_60s PF00428.19 ETO13828.1 - 0.012 16.1 7.3 0.013 16.1 3.6 2.8 3 0 0 3 3 3 0 60s Acidic ribosomal protein CDC45 PF02724.14 ETO13828.1 - 0.25 9.6 13.8 0.44 8.8 13.8 1.4 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 ETO13828.1 - 0.38 10.4 16.0 0.77 9.4 16.0 1.6 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) HrpB7 PF09486.10 ETO13829.1 - 0.00081 19.8 1.6 0.0015 18.9 1.6 1.5 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) DUF2203 PF09969.9 ETO13829.1 - 0.02 15.6 2.1 0.02 15.6 2.1 2.5 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.15 ETO13829.1 - 0.26 10.8 9.3 0.38 10.3 9.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Asp-B-Hydro_N PF05279.11 ETO13829.1 - 1 9.4 9.5 1.7 8.6 9.5 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Drc1-Sld2 PF11719.8 ETO13829.1 - 2.1 7.8 17.5 5.5 6.4 17.5 1.7 1 1 0 1 1 1 0 DNA replication and checkpoint protein LMBR1 PF04791.16 ETO13829.1 - 6.1 5.6 9.4 7.4 5.3 9.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 ETO13829.1 - 7.4 5.8 13.3 17 4.6 13.6 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RadC PF04002.15 ETO13830.1 - 0.55 10.2 8.1 3.3 7.7 0.1 2.5 3 0 0 3 3 3 0 RadC-like JAB domain DUF1642 PF07852.11 ETO13831.1 - 0.028 15.0 0.0 0.038 14.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1642) DSHCT PF08148.12 ETO13831.1 - 0.068 12.8 0.0 0.07 12.8 0.0 1.0 1 0 0 1 1 1 0 DSHCT (NUC185) domain CENP-B_dimeris PF09026.10 ETO13833.1 - 0.023 15.1 3.2 1.3 9.4 0.5 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Mucin PF01456.17 ETO13833.1 - 0.73 9.8 46.9 0.22 11.5 29.9 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein RR_TM4-6 PF06459.12 ETO13833.1 - 0.93 9.3 49.2 1.8 8.3 19.7 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CDC27 PF09507.10 ETO13833.1 - 6.3 6.1 61.5 0.3 10.4 24.9 2.4 3 0 0 3 3 3 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 ETO13833.1 - 7.2 5.3 38.1 2 7.1 14.6 2.4 2 0 0 2 2 2 0 Presenilin PPP4R2 PF09184.11 ETO13833.1 - 7.3 6.1 40.6 2.1 7.9 16.8 2.2 2 0 0 2 2 2 0 PPP4R2 FERM_F1 PF18379.1 ETO13835.1 - 0.022 14.7 0.1 4.5 7.4 0.1 2.8 1 1 1 2 2 2 0 FERM F1 ubiquitin-like domain WD40 PF00400.32 ETO13835.1 - 0.033 15.1 1.0 0.19 12.7 0.2 2.4 1 1 1 2 2 2 0 WD domain, G-beta repeat WD40 PF00400.32 ETO13836.1 - 2.2e-13 50.4 13.0 0.00031 21.5 0.1 6.7 7 0 0 7 7 7 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13836.1 - 2.3e-11 43.8 2.9 1.3e-06 28.6 0.0 4.7 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO13836.1 - 2.6e-06 27.4 4.1 0.035 14.0 0.0 3.6 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A CAF1C_H4-bd PF12265.8 ETO13836.1 - 0.0041 17.4 4.5 0.55 10.5 0.1 4.1 3 1 0 3 3 3 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex PKD_channel PF08016.12 ETO13837.1 - 6.2e-34 117.4 15.2 7.7e-34 117.1 15.2 1.1 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 ETO13837.1 - 2e-14 53.4 21.1 3.8e-14 52.5 21.1 1.4 1 0 0 1 1 1 1 Ion transport protein EF-hand_1 PF00036.32 ETO13837.1 - 5e-07 28.8 0.3 0.056 13.0 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 ETO13837.1 - 1.1e-06 27.8 0.4 0.0062 16.0 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO13837.1 - 7.8e-05 22.3 4.8 0.24 11.4 0.0 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO13837.1 - 0.00037 20.9 0.2 0.026 15.0 0.4 2.6 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO13837.1 - 0.0025 18.1 0.0 0.0059 16.9 0.0 1.6 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 ETO13837.1 - 0.027 14.3 0.0 3.7 7.5 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair Ac76 PF05814.11 ETO13837.1 - 0.049 13.7 3.5 4 7.5 0.1 3.3 3 0 0 3 3 3 0 Orf76 (Ac76) RepA1_leader PF08048.12 ETO13837.1 - 3 8.2 4.7 0.77 10.1 0.6 2.1 2 0 0 2 2 2 0 Tap RepA1 leader peptide ZapB PF06005.12 ETO13838.1 - 0.035 14.5 2.9 0.11 13.0 2.9 1.8 1 0 0 1 1 1 0 Cell division protein ZapB FadA PF09403.10 ETO13838.1 - 0.16 12.4 5.4 9.6 6.8 1.0 2.8 1 1 1 2 2 2 0 Adhesion protein FadA Syntaxin-6_N PF09177.11 ETO13838.1 - 0.23 12.0 2.8 0.8 10.3 1.2 2.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Steroid_dh PF02544.16 ETO13839.1 - 3.3e-27 95.3 0.2 6.5e-27 94.4 0.2 1.5 1 0 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase PEMT PF04191.13 ETO13839.1 - 5e-05 23.6 0.9 0.00013 22.3 0.9 1.7 1 0 0 1 1 1 1 Phospholipid methyltransferase Pkinase PF00069.25 ETO13840.1 - 3.8e-07 29.7 0.1 7.9e-07 28.7 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain FliD_N PF02465.18 ETO13840.1 - 0.0083 16.8 0.1 0.011 16.5 0.1 1.3 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus Spa1_C PF18218.1 ETO13840.1 - 0.039 14.4 0.7 0.063 13.7 0.7 1.4 1 0 0 1 1 1 0 Lantibiotic immunity protein Spa1 C-terminal domain RPN2_C PF18004.1 ETO13841.1 - 5.3 6.9 9.6 0.44 10.4 3.2 2.0 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Ndc1_Nup PF09531.10 ETO13842.1 - 0.031 13.0 18.3 0.035 12.8 18.3 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CENP-B_dimeris PF09026.10 ETO13843.1 - 1.7 9.1 11.5 2.9 8.3 11.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PP2C PF00481.21 ETO13844.1 - 6.2e-23 81.7 0.0 1.3e-22 80.7 0.0 1.5 1 1 0 1 1 1 1 Protein phosphatase 2C BB_PF PF18063.1 ETO13844.1 - 0.034 13.8 1.2 2 8.0 0.0 2.4 2 0 0 2 2 2 0 Beta barrel Pore-forming domain FSA_C PF10479.9 ETO13844.1 - 0.094 10.8 6.8 0.15 10.2 6.8 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus WD40 PF00400.32 ETO13845.1 - 3e-53 176.6 22.4 2.4e-09 37.6 0.2 7.8 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13845.1 - 2.6e-14 53.3 1.2 0.0031 17.8 0.0 6.0 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13845.1 - 2.4e-10 39.9 3.1 0.07 12.1 0.0 5.9 2 2 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO13845.1 - 4.2e-08 32.9 4.9 0.001 18.5 0.3 3.1 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO13845.1 - 0.00019 20.3 2.3 2.3 6.7 0.0 4.9 4 2 1 5 5 5 2 Nucleoporin Nup120/160 Kelch_4 PF13418.6 ETO13845.1 - 0.0017 18.3 0.0 0.0042 17.0 0.0 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO13845.1 - 0.013 15.8 0.0 0.065 13.5 0.0 2.3 1 0 0 1 1 1 0 Kelch motif PD40 PF07676.12 ETO13845.1 - 0.16 11.9 6.4 36 4.5 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Sad1_UNC PF07738.13 ETO13847.1 - 0.00059 19.8 0.1 0.0015 18.5 0.0 1.6 1 1 0 2 2 2 1 Sad1 / UNC-like C-terminal Gastrin PF00918.17 ETO13847.1 - 0.025 15.5 1.0 0.033 15.1 1.0 1.2 1 0 0 1 1 1 0 Gastrin/cholecystokinin family NifQ PF04891.12 ETO13847.1 - 0.11 12.9 0.1 0.14 12.5 0.1 1.2 1 0 0 1 1 1 0 NifQ CDC45 PF02724.14 ETO13848.1 - 0.011 14.0 1.8 0.011 14.1 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO13848.1 - 0.016 15.5 6.7 0.024 15.0 6.7 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RPN2_C PF18004.1 ETO13848.1 - 0.024 14.5 8.2 0.04 13.8 8.2 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Spc7 PF08317.11 ETO13848.1 - 0.038 12.9 7.2 0.061 12.2 7.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DDHD PF02862.17 ETO13848.1 - 0.047 13.8 0.3 0.054 13.7 0.3 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 ETO13848.1 - 0.18 11.6 6.6 0.24 11.2 6.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Orf78 PF06024.12 ETO13848.1 - 0.36 11.2 1.5 2.5 8.5 0.9 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Med19 PF10278.9 ETO13848.1 - 0.39 10.6 11.2 0.63 10.0 11.2 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Presenilin PF01080.17 ETO13848.1 - 0.39 9.4 3.4 0.55 8.9 3.4 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 ETO13848.1 - 0.62 10.1 4.6 1.3 9.1 4.6 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4519 PF15012.6 ETO13848.1 - 9.7 6.5 14.4 0.61 10.3 9.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) Bac_export_2 PF01312.19 ETO13849.1 - 0.11 11.7 0.4 0.14 11.3 0.4 1.1 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family Renin_r PF07850.14 ETO13849.1 - 1.8 9.2 4.0 33 5.2 2.8 2.2 2 0 0 2 2 2 0 Renin receptor-like protein DUF4770 PF15994.5 ETO13850.1 - 0.016 15.4 0.3 0.022 15.0 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RP-C_C PF11800.8 ETO13850.1 - 0.26 11.3 3.8 0.4 10.7 3.8 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 ETO13850.1 - 0.35 10.0 1.3 0.38 9.9 1.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PglZ PF08665.12 ETO13851.1 - 3.9 7.5 6.2 0.67 10.0 2.5 1.7 2 0 0 2 2 2 0 PglZ domain EF-hand_1 PF00036.32 ETO13852.1 - 4.8e-08 32.0 0.1 3.1e-06 26.3 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO13852.1 - 2e-06 28.1 0.1 0.002 18.5 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO13852.1 - 1e-05 25.0 0.6 0.0007 19.3 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ETO13852.1 - 1.2e-05 25.1 0.2 0.015 15.1 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO13852.1 - 0.0046 16.4 0.3 0.015 14.8 0.3 1.8 1 0 0 1 1 1 1 EF hand SPARC_Ca_bdg PF10591.9 ETO13852.1 - 0.22 11.8 5.6 3.5 8.0 0.0 3.6 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region adh_short_C2 PF13561.6 ETO13853.1 - 2.5e-56 190.9 0.0 3.3e-56 190.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO13853.1 - 2.4e-39 134.8 0.3 3.6e-39 134.2 0.3 1.2 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO13853.1 - 4.8e-09 36.4 0.0 7.6e-09 35.7 0.0 1.2 1 0 0 1 1 1 1 KR domain HMMR_C PF15908.5 ETO13853.1 - 0.0039 17.5 2.6 0.0075 16.5 2.6 1.4 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor C-terminal BRCT_assoc PF12820.7 ETO13853.1 - 0.015 15.1 0.9 0.023 14.5 0.9 1.3 1 0 0 1 1 1 0 Serine-rich domain associated with BRCT IMS PF00817.20 ETO13853.1 - 0.027 14.4 0.5 0.038 14.0 0.5 1.5 1 1 0 1 1 1 0 impB/mucB/samB family 3HCDH_N PF02737.18 ETO13853.1 - 0.035 14.0 0.3 0.089 12.7 0.3 1.7 1 1 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Spindle_Spc25 PF08234.12 ETO13853.1 - 0.043 14.0 0.0 0.095 12.9 0.0 1.6 1 0 0 1 1 1 0 Chromosome segregation protein Spc25 Polysacc_synt_2 PF02719.15 ETO13853.1 - 0.087 11.9 2.3 0.14 11.3 2.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein 2-Hacid_dh_C PF02826.19 ETO13853.1 - 0.11 11.8 0.5 0.23 10.8 0.2 1.6 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain IMPDH PF00478.25 ETO13853.1 - 0.12 11.4 0.4 0.17 10.9 0.4 1.1 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain MMR_HSR1 PF01926.23 ETO13853.1 - 0.14 12.2 1.5 0.18 11.9 0.3 1.7 2 0 0 2 2 1 0 50S ribosome-binding GTPase Fungal_TACC PF12709.7 ETO13853.1 - 0.43 11.1 4.4 0.12 12.8 1.3 1.7 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins tRNA_edit PF04073.15 ETO13854.1 - 3.3e-08 33.6 0.0 8.4e-08 32.3 0.0 1.7 1 1 0 1 1 1 1 Aminoacyl-tRNA editing domain DUF382 PF04037.13 ETO13854.1 - 0.076 13.2 2.9 0.19 11.9 2.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF382) Ribosomal_S5 PF00333.20 ETO13855.1 - 1e-24 86.3 0.3 2e-24 85.3 0.3 1.5 1 0 0 1 1 1 1 Ribosomal protein S5, N-terminal domain Ribosomal_S5_C PF03719.15 ETO13855.1 - 1.4e-24 85.3 0.1 2.1e-24 84.8 0.1 1.3 1 0 0 1 1 1 1 Ribosomal protein S5, C-terminal domain Pkinase PF00069.25 ETO13856.1 - 1.7e-103 345.6 2.7 9.5e-52 176.0 0.1 3.9 3 1 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13856.1 - 6.8e-49 166.5 0.5 1.1e-24 87.1 0.0 3.8 3 1 0 3 3 3 3 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO13856.1 - 1.6e-24 83.6 13.6 3.5e-06 26.2 0.4 5.0 5 0 0 5 5 4 4 EF hand EF-hand_7 PF13499.6 ETO13856.1 - 8.7e-20 71.0 10.4 3.3e-10 40.3 2.5 3.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO13856.1 - 5.6e-17 60.2 9.7 8.6e-06 25.3 0.1 5.3 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ETO13856.1 - 1.1e-15 56.3 11.3 1.9e-06 27.1 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO13856.1 - 1.2e-11 44.2 10.1 0.00017 21.4 1.5 5.3 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO13856.1 - 1.1e-07 32.2 0.8 0.0021 18.4 0.3 3.8 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Kdo PF06293.14 ETO13856.1 - 1.2e-07 31.4 0.5 7.1e-05 22.2 0.0 2.8 2 0 0 2 2 2 2 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO13856.1 - 5.7e-07 29.7 0.0 0.072 13.0 0.0 3.2 3 0 0 3 3 3 2 Phosphotransferase enzyme family Mad3_BUB1_I PF08311.12 ETO13856.1 - 1.2e-06 28.5 4.1 4.8e-06 26.6 0.2 3.2 3 0 0 3 3 3 1 Mad3/BUB1 homology region 1 FTA2 PF13095.6 ETO13856.1 - 8.6e-06 25.5 2.1 0.88 9.1 0.0 3.6 2 1 1 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ETO13856.1 - 7e-05 22.5 1.6 0.015 15.0 0.2 2.9 2 1 0 2 2 2 1 RIO1 family Kinase-like PF14531.6 ETO13856.1 - 9.1e-05 21.9 0.2 1.3 8.2 0.1 3.7 2 1 0 2 2 2 2 Kinase-like Mad3_BUB1_I_2 PF17014.5 ETO13856.1 - 0.00029 21.0 0.1 0.0012 18.9 0.1 2.1 1 0 0 1 1 1 1 Putative Mad3/BUB1 like region 1 protein DUF2680 PF10925.8 ETO13856.1 - 0.0027 17.6 1.1 0.012 15.6 0.2 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2680) YrbL-PhoP_reg PF10707.9 ETO13856.1 - 0.034 13.7 0.1 0.17 11.4 0.1 2.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL ASFV_J13L PF05568.11 ETO13856.1 - 0.042 13.6 6.5 0.078 12.7 6.5 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein EF-hand_9 PF14658.6 ETO13856.1 - 0.083 13.2 0.9 0.97 9.8 0.2 3.0 2 1 0 2 2 2 0 EF-hand domain Mucin PF01456.17 ETO13856.1 - 0.17 11.9 16.2 0.34 10.9 16.2 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 ETO13856.1 - 0.32 11.0 6.8 0.76 9.7 6.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) EF-hand_4 PF12763.7 ETO13856.1 - 1.8 8.6 11.9 39 4.3 1.0 5.0 3 1 1 5 5 5 0 Cytoskeletal-regulatory complex EF hand CLN3 PF02487.17 ETO13857.1 - 0.00034 19.8 5.3 0.00034 19.8 5.3 2.5 1 1 2 3 3 3 1 CLN3 protein RNA_pol_Rpc4 PF05132.14 ETO13857.1 - 0.0029 18.1 19.5 0.0029 18.1 19.5 4.0 2 1 2 4 4 4 1 RNA polymerase III RPC4 SID-1_RNA_chan PF13965.6 ETO13857.1 - 0.007 14.8 15.4 0.0062 15.0 14.3 1.4 1 1 0 1 1 1 1 dsRNA-gated channel SID-1 LysE PF01810.18 ETO13857.1 - 0.5 9.8 1.3 1 8.8 0.0 2.0 2 0 0 2 2 2 0 LysE type translocator Mucin PF01456.17 ETO13859.1 - 0.004 17.2 21.8 0.004 17.2 21.8 1.9 2 0 0 2 2 2 1 Mucin-like glycoprotein DUF3439 PF11921.8 ETO13859.1 - 0.14 12.1 15.6 0.28 11.2 15.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ANAPC_CDC26 PF10471.9 ETO13859.1 - 1.7 9.6 9.9 11 6.9 0.4 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Med13_C PF06333.12 ETO13859.1 - 1.7 7.8 7.6 0.63 9.3 4.3 1.7 2 0 0 2 2 2 0 Mediator complex subunit 13 C-terminal domain TonB_N PF16031.5 ETO13859.1 - 1.8 9.1 8.9 2.9 8.4 8.9 1.2 1 0 0 1 1 1 0 TonB polyproline region Presenilin PF01080.17 ETO13859.1 - 5.9 5.6 6.1 0.46 9.2 1.5 1.5 2 0 0 2 2 2 0 Presenilin SPC25 PF06703.11 ETO13860.1 - 2.7 7.8 6.7 5.6 6.7 6.7 1.7 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) PARP PF00644.20 ETO13861.1 - 1.2e-05 25.0 0.0 1.9e-05 24.3 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain RNA_pol_Rpb1_1 PF04997.12 ETO13861.1 - 0.00018 21.0 0.0 0.00028 20.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 1 GET2 PF08690.10 ETO13862.1 - 0.00088 19.0 1.9 0.0011 18.8 1.9 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 Cwf_Cwc_15 PF04889.12 ETO13862.1 - 0.037 13.8 18.0 0.054 13.2 18.0 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CPSF100_C PF13299.6 ETO13862.1 - 0.057 13.6 3.3 0.077 13.2 3.3 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 ETO13862.1 - 0.07 11.2 21.2 0.082 11.0 21.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETO13862.1 - 0.57 8.6 14.1 0.66 8.4 14.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sporozoite_P67 PF05642.11 ETO13862.1 - 0.65 8.0 11.7 1 7.4 11.7 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Nop14 PF04147.12 ETO13862.1 - 0.86 7.7 19.1 1 7.5 19.1 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2151 PF10221.9 ETO13862.1 - 1.3 7.6 8.9 1.6 7.3 8.9 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Tim54 PF11711.8 ETO13862.1 - 1.7 7.3 7.0 2 7.1 7.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Menin PF05053.13 ETO13862.1 - 2.2 6.5 8.9 3.2 6.0 8.9 1.2 1 0 0 1 1 1 0 Menin Gti1_Pac2 PF09729.9 ETO13862.1 - 3.3 7.8 8.3 4.5 7.3 8.3 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family CDC45 PF02724.14 ETO13862.1 - 4.2 5.5 15.2 5.1 5.3 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 ETO13862.1 - 4.4 7.0 13.6 8.1 6.2 13.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) BUD22 PF09073.10 ETO13862.1 - 5.5 6.2 20.6 7.1 5.9 20.6 1.1 1 0 0 1 1 1 0 BUD22 NPR3 PF03666.13 ETO13862.1 - 5.6 5.6 13.3 7.4 5.2 13.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SDA1 PF05285.12 ETO13862.1 - 5.7 6.3 21.8 7.3 5.9 21.8 1.1 1 0 0 1 1 1 0 SDA1 FAM60A PF15396.6 ETO13862.1 - 8 6.4 8.1 11 5.9 8.1 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DUF2457 PF10446.9 ETO13862.1 - 8.1 5.5 26.3 11 5.0 26.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ndc1_Nup PF09531.10 ETO13862.1 - 9.1 4.8 8.8 0.69 8.5 0.3 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ETO13865.1 - 0.35 9.6 16.9 0.41 9.3 16.9 1.0 1 0 0 1 1 1 0 Presenilin MCM_bind PF09739.9 ETO13865.1 - 0.63 8.4 15.0 0.74 8.2 15.0 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor POP1 PF06978.11 ETO13865.1 - 0.71 9.8 13.8 0.97 9.4 13.8 1.2 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 DUF3563 PF12086.8 ETO13865.1 - 0.76 9.5 0.1 0.76 9.5 0.1 3.2 3 1 1 4 4 4 0 Protein of unknown function (DUF3563) CDC45 PF02724.14 ETO13865.1 - 1.1 7.4 22.0 1.2 7.3 22.0 1.3 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 ETO13865.1 - 1.4 9.0 11.1 1.9 8.6 11.1 1.2 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.12 ETO13865.1 - 1.9 6.6 29.9 1.9 6.6 29.9 1.0 1 0 0 1 1 1 0 Nop14-like family SLC12 PF03522.15 ETO13865.1 - 2.6 7.0 19.0 3 6.8 19.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 ETO13865.1 - 4.7 5.9 18.2 5.8 5.6 18.2 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Smg8_Smg9 PF10220.9 ETO13865.1 - 5.2 5.3 14.4 6 5.0 14.4 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Neur_chan_memb PF02932.16 ETO13865.1 - 6 6.9 10.5 7.6 6.5 10.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NOA36 PF06524.12 ETO13865.1 - 7.1 5.9 21.2 12 5.1 21.2 1.4 1 0 0 1 1 1 0 NOA36 protein FAM60A PF15396.6 ETO13865.1 - 9.9 6.1 15.7 13 5.7 15.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A AAA_12 PF13087.6 ETO13866.1 - 5.8e-45 153.4 1.0 5.8e-45 153.4 1.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ETO13866.1 - 4.6e-30 105.3 0.0 1.8e-15 57.4 0.0 2.2 1 1 1 2 2 2 2 AAA domain AAA_19 PF13245.6 ETO13866.1 - 8.2e-10 39.2 0.0 2e-09 37.9 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO13866.1 - 2.4e-07 30.7 0.0 4.1e-06 26.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ETO13866.1 - 0.0064 16.3 2.7 2.4 7.8 0.0 3.9 3 1 0 3 3 3 1 Viral (Superfamily 1) RNA helicase DUF2075 PF09848.9 ETO13866.1 - 0.0066 15.7 0.5 0.17 11.1 0.0 2.7 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) PIF1 PF05970.14 ETO13866.1 - 0.011 14.9 2.1 0.11 11.7 1.5 2.4 2 1 0 2 2 2 0 PIF1-like helicase AAA PF00004.29 ETO13866.1 - 0.015 15.7 1.3 0.07 13.6 0.5 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO13866.1 - 0.017 15.4 0.3 0.45 10.8 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO13866.1 - 0.048 13.4 0.1 0.3 10.8 0.1 2.2 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 ETO13866.1 - 0.05 13.6 1.3 6.4 6.7 0.0 3.1 3 1 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_16 PF13191.6 ETO13866.1 - 0.063 13.7 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain PhoH PF02562.16 ETO13866.1 - 0.13 11.7 0.0 0.32 10.4 0.0 1.6 1 0 0 1 1 1 0 PhoH-like protein CAP_GLY PF01302.25 ETO13867.1 - 7.6e-06 25.9 0.0 1.3e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain Bac_transf PF02397.16 ETO13868.1 - 0.12 12.0 0.0 0.2 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial sugar transferase Diphthamide_syn PF01866.17 ETO13869.1 - 4.7e-16 59.1 0.7 1.1e-08 34.9 0.1 2.8 3 0 0 3 3 3 2 Putative diphthamide synthesis protein Diphthamide_syn PF01866.17 ETO13870.1 - 1.5e-18 67.3 0.4 1.9e-18 67.0 0.4 1.1 1 0 0 1 1 1 1 Putative diphthamide synthesis protein DUF5611 PF18446.1 ETO13870.1 - 0.071 14.0 0.1 0.093 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5611) Ribosomal_L19e PF01280.20 ETO13871.1 - 7.1e-13 48.8 5.6 7.1e-13 48.8 5.6 2.4 2 1 0 2 2 2 1 Ribosomal protein L19e RR_TM4-6 PF06459.12 ETO13871.1 - 5.4 6.8 17.5 6.4 6.5 17.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 ETO13871.1 - 7.9 6.5 6.3 8.2 6.4 6.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 ETO13871.1 - 9 4.3 11.3 9.8 4.2 11.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HHH_9 PF17674.1 ETO13872.1 - 1.3 10.0 3.9 3.6 8.6 0.1 3.0 3 0 0 3 3 3 0 HHH domain EIF_2_alpha PF07541.12 ETO13874.1 - 1.9e-42 144.0 0.7 1.9e-42 144.0 0.7 2.0 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ETO13874.1 - 2.3e-08 34.3 0.1 5.4e-08 33.1 0.1 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Dsh_C PF12316.8 ETO13875.1 - 0.11 12.9 10.0 0.22 11.9 10.0 1.6 1 1 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal WD40 PF00400.32 ETO13876.1 - 1.2e-54 181.0 15.0 3.6e-09 37.1 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13876.1 - 3.6e-25 88.1 1.9 0.00069 19.9 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13876.1 - 1.9e-15 56.7 1.8 0.012 14.5 0.0 5.9 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO13876.1 - 3e-11 43.2 0.9 0.0013 18.2 0.1 3.4 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO13876.1 - 1.4e-09 37.1 4.5 0.29 9.7 0.0 5.2 2 2 4 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO13876.1 - 4.1e-08 33.3 0.0 0.0029 17.5 0.0 2.9 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO13876.1 - 3.4e-06 25.9 0.2 0.21 10.1 0.0 3.3 3 0 0 3 3 3 3 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO13876.1 - 0.00013 21.4 2.0 0.76 9.1 0.1 4.1 1 1 4 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO13876.1 - 0.004 16.3 0.1 0.076 12.1 0.0 2.4 2 1 0 2 2 2 1 Coatomer WD associated region PD40 PF07676.12 ETO13876.1 - 0.0067 16.3 4.7 4.3 7.4 0.3 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF1652 PF07865.11 ETO13876.1 - 0.026 14.3 0.0 17 5.3 0.0 4.1 4 1 1 5 5 5 0 Protein of unknown function (DUF1652) EFP_N PF08207.12 ETO13876.1 - 0.055 13.5 0.0 0.38 10.8 0.0 2.4 3 0 0 3 3 3 0 Elongation factor P (EF-P) KOW-like domain N-glycanase_N PF09112.10 ETO13876.1 - 0.09 12.6 0.2 0.69 9.7 0.0 2.2 2 0 0 2 2 2 0 Peptide-N-glycosidase F, N terminal Proteasome_A_N PF10584.9 ETO13876.1 - 0.24 11.1 1.7 37 4.1 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature SASA PF03629.18 ETO13878.1 - 1.1e-07 31.8 0.0 2e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Carbohydrate esterase, sialic acid-specific acetylesterase DUF3602 PF12223.8 ETO13879.1 - 0.0044 17.6 0.2 0.013 16.1 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF3602) DUF4201 PF13870.6 ETO13879.1 - 0.078 12.7 21.0 0.014 15.1 13.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) DUF4349 PF14257.6 ETO13879.1 - 0.12 11.8 1.2 1.1 8.7 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) DUF3450 PF11932.8 ETO13879.1 - 0.36 10.1 11.9 0.59 9.4 5.0 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO13879.1 - 0.58 10.2 14.0 3 7.9 0.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Ago_N_1 PF18351.1 ETO13879.1 - 0.76 10.2 4.0 3.1 8.3 0.3 2.6 2 0 0 2 2 2 0 Fungal Argonaute N-terminal domain BLOC1_2 PF10046.9 ETO13879.1 - 2 8.8 20.0 0.057 13.7 1.8 3.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF948 PF06103.11 ETO13879.1 - 2.5 8.4 14.8 39 4.6 5.5 4.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) L31 PF09784.9 ETO13879.1 - 2.7 8.5 6.0 38 4.8 0.1 3.5 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L31 NPV_P10 PF05531.12 ETO13879.1 - 4 8.0 12.5 1.5 9.4 0.3 4.2 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TBCA PF02970.16 ETO13879.1 - 6.1 7.2 19.4 0.041 14.2 3.9 3.7 1 1 1 3 3 3 0 Tubulin binding cofactor A PspA_IM30 PF04012.12 ETO13879.1 - 7.5 6.1 12.7 0.46 10.0 1.9 2.8 2 1 0 3 3 3 0 PspA/IM30 family zf-CCHC PF00098.23 ETO13880.1 - 0.12 12.4 10.2 3.5 7.9 0.1 2.6 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_4 PF14392.6 ETO13880.1 - 4.6 7.1 10.2 0.34 10.7 2.8 2.7 3 0 0 3 3 3 0 Zinc knuckle TTL PF03133.15 ETO13882.1 - 2.3e-43 148.5 3.6 9.7e-28 97.1 1.1 2.7 1 1 1 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ETO13882.1 - 1.2e-07 31.3 0.9 9.3e-05 21.8 0.0 2.4 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ETO13882.1 - 5.8e-05 22.5 0.0 0.0026 17.1 0.0 2.3 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp Folate_carrier PF01770.18 ETO13882.1 - 0.18 10.5 0.3 0.35 9.6 0.3 1.4 1 0 0 1 1 1 0 Reduced folate carrier Aminotran_3 PF00202.21 ETO13884.1 - 4.1e-45 154.1 0.0 4.6e-45 154.0 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III EF-hand_1 PF00036.32 ETO13885.1 - 1.2e-06 27.6 0.5 2.8e-06 26.5 0.5 1.7 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO13885.1 - 1.4e-05 24.6 0.7 3.9e-05 23.2 0.7 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETO13885.1 - 1.9e-05 25.0 0.2 4.3e-05 23.9 0.2 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO13885.1 - 0.0012 18.3 0.6 0.0043 16.5 0.6 2.0 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 ETO13885.1 - 0.0056 16.5 0.1 0.011 15.6 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO13885.1 - 0.086 13.2 11.3 0.089 13.1 0.5 3.3 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region YABBY PF04690.13 ETO13886.1 - 3.5 8.2 6.3 1.2 9.7 1.0 2.3 2 0 0 2 2 2 0 YABBY protein WD40 PF00400.32 ETO13887.1 - 1.6e-66 218.6 15.7 1.9e-10 41.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13887.1 - 1.7e-19 69.9 4.3 0.1 12.9 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13887.1 - 2.5e-16 59.6 2.2 0.0029 16.6 0.0 6.8 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO13887.1 - 2.4e-12 46.8 2.4 0.00039 19.9 0.0 4.0 1 1 3 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO13887.1 - 5e-12 46.1 3.8 0.00022 21.2 0.2 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO13887.1 - 1.4e-08 34.5 9.0 0.43 10.6 0.2 5.7 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO13887.1 - 9.8e-08 31.1 6.3 0.31 9.6 0.3 5.4 1 1 4 5 5 5 3 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO13887.1 - 2.9e-07 29.9 4.7 0.00046 19.4 2.0 2.5 1 1 0 2 2 2 2 Coatomer WD associated region Nbas_N PF15492.6 ETO13887.1 - 4.8e-05 22.8 1.7 0.85 8.9 0.1 4.3 1 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO13887.1 - 5e-05 22.0 1.7 0.17 10.4 0.2 3.2 1 1 2 4 4 4 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO13887.1 - 0.00012 20.9 11.4 0.026 13.3 0.6 4.7 1 1 3 4 4 4 2 Nup133 N terminal like DUF2314 PF10077.9 ETO13887.1 - 0.0046 17.0 0.7 0.042 13.9 0.0 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2314) DHFR_2 PF06442.11 ETO13887.1 - 0.11 12.3 0.0 4.5 7.2 0.0 2.9 3 0 0 3 3 3 0 R67 dihydrofolate reductase DUF1854 PF08909.11 ETO13887.1 - 0.19 11.6 2.2 0.44 10.4 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1854) CBM65_1 PF18259.1 ETO13887.1 - 0.32 11.2 4.8 0.22 11.7 0.9 2.7 2 1 1 3 3 3 0 Carbohydrate binding module 65 domain 1 Proteasome_A_N PF10584.9 ETO13887.1 - 0.36 10.5 6.8 25 4.6 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature LCE6A PF15858.5 ETO13891.1 - 0.065 14.0 1.6 0.15 12.8 0.4 2.3 1 1 1 2 2 2 0 Late cornified envelope protein 6A family zf-RanBP PF00641.18 ETO13893.1 - 0.0098 15.2 1.1 0.018 14.3 1.1 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RR_TM4-6 PF06459.12 ETO13893.1 - 0.023 14.5 1.3 0.026 14.3 1.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PHC2_SAM_assoc PF16616.5 ETO13893.1 - 0.029 15.2 5.6 0.047 14.5 5.6 1.3 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 CLN3 PF02487.17 ETO13893.1 - 0.037 13.1 0.1 0.042 12.9 0.1 1.1 1 0 0 1 1 1 0 CLN3 protein RNA_pol_Rpc4 PF05132.14 ETO13893.1 - 0.038 14.4 5.0 0.051 14.0 5.0 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Tim54 PF11711.8 ETO13893.1 - 0.38 9.5 4.3 0.51 9.1 4.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Cytomega_UL84 PF06284.11 ETO13893.1 - 0.73 8.2 7.6 1 7.7 7.6 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein ADIP PF11559.8 ETO13894.1 - 0.01 15.9 6.6 0.01 15.9 6.6 4.2 2 2 3 5 5 5 0 Afadin- and alpha -actinin-Binding HALZ PF02183.18 ETO13894.1 - 0.14 12.4 0.4 0.14 12.4 0.4 5.9 4 2 3 7 7 7 0 Homeobox associated leucine zipper DUF1664 PF07889.12 ETO13894.1 - 9.4 6.3 18.4 0.1 12.6 4.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) TTL PF03133.15 ETO13896.1 - 1.4e-10 40.8 0.0 2.5e-10 40.0 0.0 1.5 1 1 0 1 1 1 1 Tubulin-tyrosine ligase family DRMBL PF07522.14 ETO13896.1 - 0.049 13.8 0.1 0.064 13.4 0.1 1.3 1 0 0 1 1 1 0 DNA repair metallo-beta-lactamase DUF3833 PF12915.7 ETO13896.1 - 0.087 12.4 0.2 0.15 11.6 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3833) V_ATPase_I PF01496.19 ETO13896.1 - 0.57 8.0 3.1 0.64 7.9 3.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nucleo_P87 PF07267.11 ETO13896.1 - 1.5 7.6 9.2 1.8 7.3 9.2 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Pkinase PF00069.25 ETO13897.1 - 1.6e-44 152.3 0.4 3.8e-44 151.0 0.4 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13897.1 - 1.6e-23 83.4 0.2 4.7e-23 81.8 0.2 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO13897.1 - 4.8e-08 32.7 0.1 1.3e-07 31.2 0.1 1.7 1 1 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO13897.1 - 0.00026 19.9 0.1 0.0023 16.8 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO13897.1 - 0.0067 15.8 0.9 0.013 14.9 0.9 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO13897.1 - 0.0068 16.4 0.1 0.016 15.1 0.1 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO13897.1 - 0.039 12.9 0.1 0.039 12.9 0.1 2.3 3 0 0 3 3 3 0 Haspin like kinase domain IBR PF01485.21 ETO13898.1 - 3.4e-07 30.4 25.7 0.00075 19.7 7.0 3.4 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ETO13898.1 - 5e-06 26.3 6.9 5e-06 26.3 6.9 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO13898.1 - 0.00028 20.7 3.4 0.00028 20.7 3.4 4.2 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO13898.1 - 0.0018 18.6 5.0 0.0018 18.6 5.0 3.5 2 1 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ETO13898.1 - 0.0026 17.8 2.6 0.0026 17.8 2.6 3.0 3 1 1 4 4 4 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO13898.1 - 0.0099 15.8 15.2 0.0099 15.8 15.2 4.0 2 2 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO13898.1 - 0.011 15.5 3.2 0.011 15.5 3.2 3.8 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 ETO13898.1 - 0.23 11.4 4.2 0.16 11.8 0.8 2.4 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_11 PF17123.5 ETO13898.1 - 3.2 7.6 14.6 0.67 9.7 7.7 2.8 3 0 0 3 3 3 0 RING-like zinc finger EPL1 PF10513.9 ETO13899.1 - 0.0015 19.0 4.8 0.0015 19.0 4.8 2.0 2 0 0 2 2 2 1 Enhancer of polycomb-like DDHD PF02862.17 ETO13899.1 - 0.0018 18.5 1.5 0.0022 18.2 0.6 1.6 2 0 0 2 2 2 1 DDHD domain DUF2722 PF10846.8 ETO13899.1 - 0.0035 16.4 15.9 0.0035 16.4 15.9 1.4 2 0 0 2 2 1 1 Protein of unknown function (DUF2722) TERB2 PF15101.6 ETO13899.1 - 0.029 14.4 7.8 0.054 13.6 7.8 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2284 PF10050.9 ETO13899.1 - 0.034 13.9 5.9 0.077 12.7 5.3 1.9 2 0 0 2 2 2 0 Predicted metal-binding protein (DUF2284) Neur_chan_memb PF02932.16 ETO13899.1 - 0.037 14.1 0.8 0.055 13.5 0.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CTU2 PF10288.9 ETO13899.1 - 0.12 12.7 10.1 0.092 13.0 7.3 2.0 2 0 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 TFIIA PF03153.13 ETO13899.1 - 0.13 12.3 20.0 0.2 11.6 20.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4175 PF13779.6 ETO13899.1 - 0.15 9.9 18.8 0.2 9.5 18.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Spt20 PF12090.8 ETO13899.1 - 0.19 11.3 30.4 0.014 15.0 24.9 1.9 2 0 0 2 2 2 0 Spt20 family Rxt3 PF08642.10 ETO13899.1 - 0.2 12.4 5.1 0.13 13.1 2.4 1.9 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 CPSF100_C PF13299.6 ETO13899.1 - 0.38 10.9 11.3 0.04 14.1 6.8 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Afi1 PF07792.12 ETO13899.1 - 0.47 10.9 15.8 0.78 10.2 12.2 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Gti1_Pac2 PF09729.9 ETO13899.1 - 0.56 10.3 9.6 0.48 10.5 7.0 1.9 2 0 0 2 2 2 0 Gti1/Pac2 family CobT PF06213.12 ETO13899.1 - 1.6 8.0 19.9 2.6 7.3 19.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nucleoside_tran PF01733.18 ETO13899.1 - 2 7.7 6.0 5.3 6.3 6.0 1.7 1 0 0 1 1 1 0 Nucleoside transporter DUF2072 PF09845.9 ETO13899.1 - 2 8.7 13.5 0.22 11.8 8.6 1.9 2 0 0 2 2 1 0 Zn-ribbon containing protein Peroxin-13_N PF04088.13 ETO13899.1 - 2.2 8.5 9.3 6.3 7.1 5.9 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Pex14_N PF04695.13 ETO13899.1 - 2.3 8.8 14.8 4.2 8.0 14.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF5308 PF17233.2 ETO13899.1 - 2.3 8.4 6.6 4.2 7.6 6.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5308) PTPRCAP PF15713.5 ETO13899.1 - 3.6 7.9 17.4 0.05 13.9 10.3 1.5 2 0 0 2 2 1 0 Protein tyrosine phosphatase receptor type C-associated SpoIIP PF07454.11 ETO13899.1 - 4 6.8 19.6 0.075 12.5 9.1 2.6 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Zip PF02535.22 ETO13899.1 - 4.2 6.5 5.6 8.1 5.6 5.6 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ETO13899.1 - 5 6.9 15.5 2.5 7.8 12.4 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 GOLD_2 PF13897.6 ETO13899.1 - 7.2 7.1 7.0 26 5.3 7.0 1.9 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Band_3_cyto PF07565.13 ETO13899.1 - 7.8 6.2 9.0 16 5.1 9.0 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain EMC3_TMCO1 PF01956.16 ETO13899.1 - 8.1 6.1 10.9 1.1 9.0 5.5 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like TMEM51 PF15345.6 ETO13899.1 - 8.3 6.2 10.4 15 5.3 10.4 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4834 PF16118.5 ETO13899.1 - 9.3 7.3 14.5 11 7.0 11.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TauD PF02668.16 ETO13900.1 - 4.4e-36 125.0 0.1 5.9e-36 124.6 0.1 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family zf-B_box PF00643.24 ETO13901.1 - 9.3e-08 32.1 8.7 9.3e-08 32.1 8.7 2.4 2 0 0 2 2 2 1 B-box zinc finger Cor1 PF04803.12 ETO13901.1 - 0.0043 17.3 2.9 0.0043 17.3 2.9 3.4 3 2 1 4 4 4 1 Cor1/Xlr/Xmr conserved region OAD_gamma PF04277.13 ETO13901.1 - 0.13 12.9 2.3 0.26 11.9 2.3 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain WW_FCH_linker PF16623.5 ETO13901.1 - 0.14 12.9 2.6 0.34 11.7 2.6 1.6 1 0 0 1 1 1 0 Unstructured linker region between on GAS7 protein Baculo_PEP_C PF04513.12 ETO13901.1 - 0.38 10.8 5.0 0.23 11.5 2.0 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RP-C_C PF11800.8 ETO13901.1 - 0.46 10.6 6.5 1 9.4 0.1 2.5 2 1 0 2 2 2 0 Replication protein C C-terminal region Lipoprotein_2 PF00921.17 ETO13901.1 - 0.73 9.3 11.8 0.21 11.1 0.2 2.3 2 0 0 2 2 2 0 Borrelia lipoprotein Striatin PF08232.12 ETO13901.1 - 0.9 10.1 14.1 0.96 10.0 4.8 2.8 3 0 0 3 3 3 0 Striatin family FTA4 PF13093.6 ETO13902.1 - 0.0021 18.0 7.5 0.0028 17.6 7.5 1.3 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Flagellar_rod PF05149.12 ETO13902.1 - 0.006 16.1 5.5 0.0078 15.7 5.5 1.3 1 0 0 1 1 1 1 Paraflagellar rod protein DUF2205 PF10224.9 ETO13902.1 - 0.026 14.5 5.4 0.026 14.5 5.4 1.8 2 0 0 2 2 2 0 Short coiled-coil protein FlgN PF05130.12 ETO13902.1 - 0.042 14.3 9.7 0.047 14.2 8.9 1.5 1 1 0 1 1 1 0 FlgN protein EMC3_TMCO1 PF01956.16 ETO13902.1 - 0.11 12.2 6.0 0.084 12.6 4.6 1.5 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Atg14 PF10186.9 ETO13902.1 - 0.16 11.0 7.4 0.18 10.8 7.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 ETO13902.1 - 1.9 6.3 7.8 2.3 6.1 7.8 1.0 1 0 0 1 1 1 0 Prominin SseC PF04888.12 ETO13902.1 - 6.4 6.3 5.8 11 5.5 5.8 1.4 1 1 0 1 1 1 0 Secretion system effector C (SseC) like family Fumble PF03630.14 ETO13903.1 - 5.6e-45 153.9 0.3 6.7e-45 153.7 0.3 1.1 1 0 0 1 1 1 1 Fumble Ion_trans PF00520.31 ETO13904.1 - 1e-25 90.4 20.4 1.4e-25 89.9 20.4 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans PF00520.31 ETO13905.1 - 4.7e-19 68.6 18.8 3.6e-12 46.0 13.6 2.3 1 1 1 2 2 2 2 Ion transport protein PKD_channel PF08016.12 ETO13905.1 - 0.11 11.2 15.4 0.14 10.8 8.9 2.8 1 1 1 3 3 3 0 Polycystin cation channel HrcA PF01628.21 ETO13905.1 - 0.11 12.4 0.1 0.15 11.9 0.1 1.2 1 0 0 1 1 1 0 HrcA protein C terminal domain WD40 PF00400.32 ETO13906.1 - 1.3e-25 89.1 24.8 4e-05 24.3 0.5 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO13906.1 - 4.1e-06 27.0 0.2 0.23 11.8 0.1 4.3 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO13906.1 - 1.8e-05 23.9 0.4 0.022 13.7 0.1 3.0 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO13906.1 - 0.00016 20.4 1.3 0.03 13.0 0.0 3.3 3 0 0 3 3 3 1 Nucleoporin Nup120/160 DUF620 PF04788.12 ETO13906.1 - 0.042 13.3 0.0 1.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF620) GPS2_interact PF15784.5 ETO13906.1 - 0.093 13.2 2.5 0.17 12.4 2.5 1.3 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain USP7_C2 PF14533.6 ETO13907.1 - 0.034 13.8 2.7 2 8.1 0.2 2.2 2 0 0 2 2 2 0 Ubiquitin-specific protease C-terminal U-box PF04564.15 ETO13908.1 - 1.7e-08 34.5 0.0 3.8e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 U-box domain zf-C3HC4 PF00097.25 ETO13908.1 - 0.00095 19.0 1.3 0.0032 17.3 1.3 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO13908.1 - 0.0038 17.3 2.3 0.0038 17.3 2.3 2.6 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING zf-C3HC4_2 PF13923.6 ETO13908.1 - 0.0095 15.8 1.3 0.023 14.5 1.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO13908.1 - 0.027 14.8 1.5 0.086 13.2 1.5 1.9 1 0 0 1 1 1 0 Ring finger domain zf-RING_UBOX PF13445.6 ETO13908.1 - 0.04 13.9 2.9 0.11 12.6 1.9 2.3 2 1 0 2 2 2 0 RING-type zinc-finger SAM_1 PF00536.30 ETO13908.1 - 0.069 13.6 0.2 0.19 12.2 0.1 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Cas6b_C PF17262.2 ETO13908.1 - 0.097 12.8 2.4 1.5 8.9 0.6 2.5 2 0 0 2 2 2 0 Cas6b C-terminal domain Ras PF00071.22 ETO13909.1 - 9.6e-38 129.3 0.2 1.2e-37 129.0 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO13909.1 - 1.8e-12 47.5 0.1 3.9e-12 46.5 0.1 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO13909.1 - 0.0011 18.4 0.3 0.0021 17.6 0.3 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO13909.1 - 0.019 14.9 0.8 0.14 12.0 0.1 2.2 1 1 0 2 2 2 0 RsgA GTPase MMR_HSR1_Xtn PF16897.5 ETO13909.1 - 0.02 14.9 0.7 0.029 14.4 0.7 1.3 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain AlaDh_PNT_C PF01262.21 ETO13909.1 - 0.066 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain MAR_sialic_bdg PF10564.9 ETO13909.1 - 0.083 12.9 0.4 0.15 12.1 0.4 1.4 1 0 0 1 1 1 0 Sialic-acid binding micronemal adhesive repeat FANCI_HD1 PF14679.6 ETO13909.1 - 0.14 12.2 0.8 0.31 11.0 0.2 1.8 2 0 0 2 2 2 0 FANCI helical domain 1 DUF4834 PF16118.5 ETO13910.1 - 0.12 13.3 1.3 2.3 9.3 0.8 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Ac76 PF05814.11 ETO13910.1 - 1.1 9.4 4.5 0.99 9.5 0.2 2.8 3 0 0 3 3 3 0 Orf76 (Ac76) PNPase PF03726.14 ETO13911.1 - 0.046 14.2 0.1 0.17 12.4 0.1 1.9 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Tim54 PF11711.8 ETO13911.1 - 0.11 11.3 4.3 0.13 11.0 4.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PIN_6 PF17146.4 ETO13911.1 - 0.18 12.3 0.2 3.6 8.2 0.0 2.4 2 0 0 2 2 2 0 PIN domain of ribonuclease Menin PF05053.13 ETO13911.1 - 2.4 6.4 14.4 3 6.1 14.4 1.2 1 0 0 1 1 1 0 Menin DUF2457 PF10446.9 ETO13912.1 - 0.3 10.2 25.9 0.29 10.2 25.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 ETO13912.1 - 0.75 9.1 14.6 0.92 8.8 14.6 1.2 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 ETO13912.1 - 2.6 6.1 22.5 3.2 5.8 22.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETO13912.1 - 7.9 4.9 10.5 8.8 4.7 10.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TPR_12 PF13424.6 ETO13913.1 - 1.5e-97 320.0 11.8 2e-20 72.8 0.1 6.3 2 2 4 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO13913.1 - 4.4e-64 210.8 0.0 6.2e-09 35.4 0.0 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13913.1 - 2.6e-52 172.6 49.3 1.5e-09 37.2 0.6 9.9 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO13913.1 - 5.1e-47 154.5 9.0 1.3e-08 34.2 0.0 8.7 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13913.1 - 1.9e-44 146.2 38.7 4.2e-07 29.6 0.3 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13913.1 - 5.3e-43 141.6 51.7 1.2e-08 34.5 0.9 9.7 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_11 PF13414.6 ETO13913.1 - 2.1e-20 72.1 30.8 8e-06 25.4 0.9 9.9 9 2 2 11 11 11 6 TPR repeat TPR_MalT PF17874.1 ETO13913.1 - 3e-18 66.3 0.0 5.3e-07 29.3 0.0 3.1 1 1 2 3 3 3 3 MalT-like TPR region TPR_17 PF13431.6 ETO13913.1 - 2.5e-16 58.8 11.8 0.02 15.3 0.0 9.0 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO13913.1 - 7.6e-14 52.1 0.0 0.032 14.9 0.0 7.4 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO13913.1 - 1.4e-13 50.5 7.0 0.4 11.4 0.0 8.6 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13913.1 - 2.4e-12 46.6 0.0 0.29 12.0 0.0 7.4 8 0 0 8 8 6 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO13913.1 - 1.2e-10 41.5 19.7 0.18 11.6 0.0 8.3 8 1 1 9 9 9 4 Domain of unknown function (DUF5113) Peptidase_C14 PF00656.22 ETO13913.1 - 1.3e-07 31.9 3.7 3.9e-07 30.3 3.7 1.8 1 1 0 1 1 1 1 Caspase domain TPR_19 PF14559.6 ETO13913.1 - 1.8e-07 31.6 0.3 0.73 10.4 0.0 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO13913.1 - 2.7e-06 27.4 20.9 0.022 14.8 0.3 7.0 7 0 0 7 7 6 2 MIT (microtubule interacting and transport) domain Mob_Pre PF01076.19 ETO13913.1 - 1.8e-05 24.7 5.6 0.002 18.0 1.1 4.8 3 2 2 5 5 5 2 Plasmid recombination enzyme TPR_3 PF07720.12 ETO13913.1 - 0.00073 19.5 23.0 0.88 9.6 0.3 7.5 8 0 0 8 8 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO13913.1 - 0.0011 19.2 20.9 0.11 12.8 0.3 5.6 3 3 2 6 6 5 3 Anaphase-promoting complex, cyclosome, subunit 3 SPO22 PF08631.10 ETO13913.1 - 0.0023 17.5 9.6 0.61 9.5 0.3 4.1 3 1 1 4 4 3 2 Meiosis protein SPO22/ZIP4 like PPR PF01535.20 ETO13913.1 - 0.0027 17.8 25.2 0.11 12.8 0.1 7.7 8 0 0 8 8 6 1 PPR repeat RPN7 PF10602.9 ETO13913.1 - 0.004 16.9 22.0 2 8.1 0.6 7.1 3 1 2 6 6 6 2 26S proteasome subunit RPN7 OrfA PF17495.2 ETO13913.1 - 0.02 15.0 0.0 45 4.3 0.0 4.5 3 1 2 5 5 4 0 Vpr-like OrfA SHNi-TPR PF10516.9 ETO13913.1 - 0.024 14.1 7.2 44 3.7 0.0 6.2 7 0 0 7 7 7 0 SHNi-TPR HTH_Bact PF18768.1 ETO13913.1 - 0.045 13.3 13.1 21 4.8 0.1 6.7 5 1 1 6 6 6 0 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO13913.1 - 0.046 13.7 12.2 0.089 12.8 1.0 4.8 4 2 1 5 5 5 0 Protein of unknown function (DUF627) DUF357 PF04010.13 ETO13913.1 - 0.049 13.7 6.0 4.7 7.4 0.0 4.8 1 1 3 4 4 4 0 Protein of unknown function (DUF357) Sel1 PF08238.12 ETO13913.1 - 0.093 13.4 11.7 38 5.1 0.1 6.5 7 0 0 7 7 6 0 Sel1 repeat DUF4810 PF16068.5 ETO13913.1 - 0.41 11.2 14.1 8.7 7.0 0.1 6.0 5 1 1 6 6 5 0 Domain of unknown function (DUF4810) DUF5638 PF18688.1 ETO13913.1 - 0.62 10.4 14.4 0.098 13.0 8.7 2.8 2 0 0 2 2 1 0 Family of unknown function (DUF5638) Polyoma_coat2 PF00761.20 ETO13914.1 - 0.11 12.2 0.1 0.15 11.8 0.1 1.1 1 0 0 1 1 1 0 Polyomavirus coat protein Glyco_transf_10 PF00852.19 ETO13915.1 - 0.00029 20.6 0.3 0.00048 19.9 0.3 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term IL28A PF15177.6 ETO13916.1 - 0.0082 16.0 0.1 0.0082 16.0 0.1 1.1 1 0 0 1 1 1 1 Interleukin-28A Exo_endo_phos PF03372.23 ETO13917.1 - 0.05 13.1 0.0 0.081 12.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family LRRC37AB_C PF14914.6 ETO13917.1 - 0.052 13.5 3.9 0.12 12.3 3.9 1.6 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain PH_12 PF16457.5 ETO13918.1 - 8e-07 29.7 0.3 8e-07 29.7 0.3 3.6 2 1 2 4 4 4 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO13918.1 - 0.00016 21.8 0.1 0.0006 19.9 0.1 2.0 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_14 PF17787.1 ETO13918.1 - 0.021 14.7 0.1 0.021 14.7 0.1 2.4 3 0 0 3 3 3 0 PH domain Presenilin PF01080.17 ETO13918.1 - 0.58 8.9 10.1 0.83 8.3 10.1 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO13918.1 - 6.9 5.8 6.2 10 5.3 6.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Dsh_C PF12316.8 ETO13918.1 - 9.7 6.5 9.7 15 5.9 9.7 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal TPD PF14811.6 ETO13919.1 - 2.2e-12 47.0 0.0 3.3e-12 46.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function TPD sequence-motif Amino_oxidase PF01593.24 ETO13920.1 - 1.6e-46 159.5 0.0 3.1e-33 115.8 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETO13920.1 - 1.1e-11 44.7 0.0 2.9e-11 43.4 0.0 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETO13920.1 - 9.3e-08 31.6 0.3 1.6e-07 30.8 0.3 1.3 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETO13920.1 - 8.1e-07 28.9 0.5 1.4e-06 28.1 0.5 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETO13920.1 - 2.3e-05 23.8 0.0 4.7e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Thi4 family FAD_oxidored PF12831.7 ETO13920.1 - 2.4e-05 23.9 0.0 0.00014 21.4 0.0 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO13920.1 - 3.2e-05 23.3 1.7 0.00025 20.4 0.0 2.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO13920.1 - 0.0011 19.5 0.0 0.0032 18.0 0.0 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETO13920.1 - 0.0011 17.7 0.1 0.0011 17.7 0.1 1.7 2 0 0 2 2 2 1 HI0933-like protein GIDA PF01134.22 ETO13920.1 - 0.0014 17.8 0.0 0.0037 16.4 0.0 1.7 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_3 PF13738.6 ETO13920.1 - 0.0037 16.6 0.0 0.0097 15.2 0.0 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETO13920.1 - 0.0039 16.5 0.1 0.0074 15.6 0.1 1.4 1 0 0 1 1 1 1 FAD binding domain AlaDh_PNT_C PF01262.21 ETO13920.1 - 0.021 14.1 0.0 0.063 12.6 0.0 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ETO13920.1 - 0.057 12.5 0.0 0.095 11.7 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein zinc_ribbon_10 PF10058.9 ETO13920.1 - 0.058 13.1 0.0 0.18 11.6 0.0 1.8 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein NAD_binding_9 PF13454.6 ETO13920.1 - 0.069 13.1 0.1 0.2 11.6 0.0 1.8 2 0 0 2 2 1 0 FAD-NAD(P)-binding DUF3245 PF11595.8 ETO13920.1 - 3.7 8.0 10.6 9 6.8 10.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Paf1 PF03985.13 ETO13921.1 - 0.042 12.9 11.0 0.055 12.5 11.0 1.2 1 0 0 1 1 1 0 Paf1 Myc_N PF01056.18 ETO13921.1 - 0.064 13.2 5.2 0.077 12.9 5.2 1.2 1 0 0 1 1 1 0 Myc amino-terminal region TRAP_alpha PF03896.16 ETO13921.1 - 0.14 11.4 7.1 0.21 10.8 7.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4471 PF14740.6 ETO13921.1 - 0.3 10.3 9.0 0.25 10.5 8.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4471) CDC45 PF02724.14 ETO13921.1 - 0.49 8.6 9.3 0.63 8.3 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 ETO13921.1 - 2.7 6.9 7.8 0.39 9.7 4.2 1.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 ETO13921.1 - 2.7 7.9 6.2 2.2 8.2 4.9 1.4 2 0 0 2 2 2 0 Protein Family FAM60A Presenilin PF01080.17 ETO13921.1 - 3.7 6.2 5.2 4.8 5.8 5.2 1.2 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO13921.1 - 6.9 5.9 10.1 11 5.2 10.1 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO13921.1 - 8.7 4.3 13.8 12 3.8 13.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi Hydantoinase_A PF01968.18 ETO13922.1 - 9.1e-64 215.5 0.0 1.1e-63 215.2 0.0 1.0 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase TrkA_C PF02080.21 ETO13923.1 - 4.7e-09 35.9 0.1 7.6e-08 32.1 0.0 2.9 3 1 1 4 4 4 1 TrkA-C domain Cupin_1 PF00190.22 ETO13924.1 - 0.056 13.1 1.3 0.44 10.1 1.1 2.3 2 1 1 3 3 3 0 Cupin Pex2_Pex12 PF04757.14 ETO13925.1 - 1.7e-24 86.7 6.3 4.1e-24 85.4 5.8 1.7 1 1 1 2 2 2 1 Pex2 / Pex12 amino terminal region TAFII28 PF04719.14 ETO13926.1 - 8e-22 77.1 1.4 1.6e-19 69.8 0.7 2.5 2 0 0 2 2 2 2 hTAFII28-like protein conserved region Papo_T_antigen PF02380.15 ETO13926.1 - 0.086 13.0 2.8 0.23 11.6 2.8 1.7 1 0 0 1 1 1 0 T-antigen specific domain Adhes-Ig_like PF09085.10 ETO13929.1 - 0.12 12.5 0.3 0.24 11.5 0.3 1.5 1 0 0 1 1 1 0 Adhesion molecule, immunoglobulin-like Styelin PF17562.2 ETO13930.1 - 0.053 13.9 1.5 0.13 12.6 1.5 1.6 1 0 0 1 1 1 0 Styelin DUF3670 PF12419.8 ETO13930.1 - 0.077 12.9 0.4 0.16 11.8 0.4 1.5 1 1 0 1 1 1 0 SNF2 Helicase protein Sporozoite_P67 PF05642.11 ETO13931.1 - 0.2 9.7 4.0 0.29 9.2 4.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4637 PF15470.6 ETO13931.1 - 0.37 10.5 6.1 0.69 9.6 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 ETO13931.1 - 2.6 6.2 10.9 3.7 5.7 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO13931.1 - 2.6 6.1 9.3 3.2 5.9 9.3 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 ETO13931.1 - 5.4 6.0 21.9 0.37 9.9 16.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ETO13931.1 - 5.8 7.4 13.0 15 6.0 13.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal 5_nucleotid PF05761.14 ETO13932.1 - 1.2e-61 209.1 0.6 1.4e-61 208.8 0.6 1.0 1 0 0 1 1 1 1 5' nucleotidase family Hydrolase_like PF13242.6 ETO13932.1 - 0.068 13.2 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 HAD-hyrolase-like DUF4365 PF14280.6 ETO13934.1 - 0.008 16.1 1.6 0.008 16.1 1.6 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4365) DUF3328 PF11807.8 ETO13934.1 - 0.019 14.8 1.0 0.029 14.1 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) ANAPC4_WD40 PF12894.7 ETO13934.1 - 0.048 14.0 0.5 0.087 13.1 0.5 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Secretin_N_2 PF07655.13 ETO13934.1 - 3.5 8.2 20.7 3.4 8.3 15.5 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Dymeclin PF09742.9 ETO13935.1 - 2.4e-23 82.5 12.1 2.1e-10 39.7 0.0 3.1 3 0 0 3 3 3 3 Dyggve-Melchior-Clausen syndrome protein Connexin PF00029.19 ETO13935.1 - 0.067 13.0 2.8 5.3 6.7 2.0 2.4 2 0 0 2 2 2 0 Connexin EIIBC-GUT_N PF03612.14 ETO13935.1 - 0.34 10.6 2.6 0.67 9.7 2.6 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF2140 PF09911.9 ETO13936.1 - 0.054 13.0 0.0 0.14 11.7 0.0 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) Ras PF00071.22 ETO13937.1 - 5.7e-13 48.8 0.0 7e-13 48.5 0.0 1.2 1 0 0 1 1 1 1 Ras family DUF4279 PF14106.6 ETO13937.1 - 0.033 14.4 0.0 0.047 13.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4279) Ras PF00071.22 ETO13938.1 - 3.3e-08 33.3 0.7 5.2e-08 32.7 0.7 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO13938.1 - 6.5e-05 23.1 0.3 0.00011 22.4 0.3 1.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO13938.1 - 0.00027 21.0 0.3 0.00045 20.3 0.3 1.4 1 1 0 1 1 1 1 50S ribosome-binding GTPase NB-ARC PF00931.22 ETO13938.1 - 0.00085 18.6 0.1 0.00086 18.6 0.1 1.2 1 0 0 1 1 1 1 NB-ARC domain RsgA_GTPase PF03193.16 ETO13938.1 - 0.0045 16.9 0.0 0.0052 16.7 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ETO13938.1 - 0.0065 16.7 0.0 0.011 16.0 0.0 1.3 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ETO13938.1 - 0.01 15.7 0.8 0.013 15.5 0.3 1.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea cobW PF02492.19 ETO13938.1 - 0.025 14.2 0.0 0.029 13.9 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Arf PF00025.21 ETO13938.1 - 0.031 13.7 0.0 0.036 13.5 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_18 PF13238.6 ETO13938.1 - 0.042 14.4 0.0 0.064 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO13938.1 - 0.12 12.5 0.0 0.23 11.6 0.0 1.4 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO13938.1 - 0.25 11.7 0.0 0.28 11.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Raco_middle PF17651.1 ETO13939.1 - 0.22 11.2 1.0 0.46 10.2 0.1 1.9 2 1 0 2 2 2 0 RACo middle region Goodbye PF17109.5 ETO13939.1 - 3.9 8.0 9.7 18 5.8 1.3 3.0 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain DUF1757 PF08560.10 ETO13941.1 - 1.7e-14 54.1 0.0 2.2e-14 53.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1757) Sec62 PF03839.16 ETO13941.1 - 0.14 11.6 0.1 0.24 10.9 0.1 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Get5_C PF18514.1 ETO13942.1 - 0.045 13.5 0.0 0.09 12.5 0.0 1.5 1 0 0 1 1 1 0 Get5 C-terminal domain Zip PF02535.22 ETO13943.1 - 0.063 12.5 0.9 0.15 11.3 0.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter CDC45 PF02724.14 ETO13943.1 - 0.3 9.3 8.2 0.44 8.8 8.2 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO13943.1 - 1.3 8.4 12.0 2.2 7.6 12.0 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO13943.1 - 3.4 5.8 14.8 0.8 7.8 11.8 1.4 2 0 0 2 2 2 0 Nop14-like family VPS13 PF16908.5 ETO13944.1 - 9.9e-18 64.8 0.2 2e-17 63.8 0.0 1.6 2 0 0 2 2 2 1 Vacuolar sorting-associated protein 13, N-terminal Astacin PF01400.24 ETO13944.1 - 0.0053 16.4 0.1 0.0088 15.7 0.1 1.3 1 0 0 1 1 1 1 Astacin (Peptidase family M12A) VPS13_mid_rpt PF16910.5 ETO13945.1 - 7.9e-08 32.0 0.1 1.3e-07 31.3 0.0 1.4 2 0 0 2 2 2 1 Repeating coiled region of VPS13 VPS13_mid_rpt PF16910.5 ETO13946.1 - 2.4e-18 66.4 1.2 2.4e-18 66.4 1.2 2.7 4 0 0 4 4 4 1 Repeating coiled region of VPS13 IZUMO PF15005.6 ETO13946.1 - 8.2 6.9 7.9 0.6 10.6 1.9 2.1 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated PI3Ka PF00613.20 ETO13948.1 - 4.5e-42 143.6 3.1 4.5e-42 143.6 3.1 1.7 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETO13948.1 - 2.5e-25 89.7 0.2 1.1e-22 81.1 0.0 3.4 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ETO13948.1 - 0.07 13.1 0.0 21 5.0 0.0 2.8 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 PI3_PI4_kinase PF00454.27 ETO13949.1 - 0.017 15.0 0.9 0.52 10.1 0.9 2.1 1 1 0 1 1 1 0 Phosphatidylinositol 3- and 4-kinase Pkinase PF00069.25 ETO13950.1 - 2.1e-18 66.6 0.0 3.4e-18 66.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13950.1 - 6.2e-15 55.2 0.1 1.5e-14 53.9 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Tmemb_9 PF05434.11 ETO13950.1 - 0.032 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 TMEM9 Mem_trans PF03547.18 ETO13950.1 - 0.16 10.3 0.0 0.21 9.9 0.0 1.1 1 0 0 1 1 1 0 Membrane transport protein RXT2_N PF08595.11 ETO13952.1 - 0.37 10.8 5.1 0.4 10.7 5.1 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 ETO13952.1 - 1.7 6.6 11.6 1.7 6.6 11.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETO13952.1 - 1.8 7.0 6.2 1.6 7.2 6.2 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 p47_phox_C PF08944.11 ETO13953.1 - 0.21 11.1 1.2 0.39 10.2 1.2 1.4 1 0 0 1 1 1 0 NADPH oxidase subunit p47Phox, C terminal domain AAA_31 PF13614.6 ETO13954.1 - 3.9e-05 23.6 0.0 7.6e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain Filament PF00038.21 ETO13955.1 - 0.0033 17.1 18.1 0.0033 17.1 18.1 5.0 1 1 2 4 4 4 1 Intermediate filament protein DUF4201 PF13870.6 ETO13955.1 - 0.0043 16.8 9.7 0.0043 16.8 9.7 9.3 2 2 5 9 9 9 2 Domain of unknown function (DUF4201) Pep3_Vps18 PF05131.14 ETO13956.1 - 3.1e-23 82.3 1.1 4.3e-23 81.8 0.1 1.8 2 0 0 2 2 2 1 Pep3/Vps18/deep orange family FHA PF00498.26 ETO13957.1 - 3.6e-13 49.6 0.3 3.1e-12 46.7 0.3 2.3 1 1 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ETO13957.1 - 9.8e-07 29.0 0.1 0.0088 16.3 0.0 2.7 1 1 1 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain zf-C3HC4_4 PF15227.6 ETO13957.1 - 0.0019 18.3 8.4 0.0058 16.8 8.4 1.9 1 1 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ETO13957.1 - 0.0041 16.9 9.7 0.02 14.8 9.7 2.2 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO13957.1 - 0.0069 16.2 8.4 0.0069 16.2 8.4 2.4 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Peroxin-13_N PF04088.13 ETO13957.1 - 0.053 13.8 0.2 0.053 13.8 0.2 3.3 3 1 0 3 3 2 0 Peroxin 13, N-terminal region DAP_B PF07930.12 ETO13957.1 - 0.16 11.9 0.0 0.16 11.9 0.0 2.3 2 1 0 2 2 2 0 D-aminopeptidase, domain B zf-C3HC4_3 PF13920.6 ETO13957.1 - 0.28 11.1 12.6 1.2 9.1 12.6 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO13957.1 - 1.3 9.2 9.9 3.5 7.7 9.9 1.8 1 0 0 1 1 1 0 RING-type zinc-finger FAM72 PF14976.6 ETO13957.1 - 1.9 8.6 8.3 21 5.3 5.9 2.9 2 1 0 2 2 2 0 FAM72 protein zf-RING_2 PF13639.6 ETO13957.1 - 2.1 8.7 13.1 5.5 7.4 13.1 1.8 1 1 0 1 1 1 0 Ring finger domain Pkinase PF00069.25 ETO13958.1 - 6.9e-36 124.0 2.2 1e-35 123.4 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO13958.1 - 4e-16 59.1 0.0 6.8e-16 58.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase UPF0258 PF06789.12 ETO13958.1 - 0.017 15.2 2.1 4.3 7.5 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0258) DUF2967 PF11179.8 ETO13958.1 - 2.1 6.3 10.2 2.7 6.0 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Dynamitin PF04912.14 ETO13959.1 - 4.6e-25 88.8 21.4 5.5e-25 88.5 21.4 1.1 1 0 0 1 1 1 1 Dynamitin Pox_A_type_inc PF04508.12 ETO13959.1 - 0.0036 17.1 3.7 0.0036 17.1 3.7 1.9 2 0 0 2 2 2 1 Viral A-type inclusion protein repeat CRA PF06589.11 ETO13959.1 - 0.007 16.5 0.5 0.007 16.5 0.5 2.7 2 1 1 3 3 3 1 Circumsporozoite-related antigen (CRA) HalX PF08663.10 ETO13959.1 - 0.063 13.6 2.0 0.68 10.3 0.1 2.9 3 0 0 3 3 3 0 HalX domain CorA PF01544.18 ETO13959.1 - 5.6 6.2 15.3 0.058 12.7 1.1 2.5 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein HTH_40 PF14493.6 ETO13960.1 - 1.3e-05 25.5 0.3 8.1e-05 23.0 0.0 2.4 2 1 1 3 3 3 1 Helix-turn-helix domain DUF1858 PF08984.11 ETO13960.1 - 0.016 15.4 0.1 0.054 13.7 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1858) FAS_I_H PF18314.1 ETO13960.1 - 0.11 12.1 0.9 0.36 10.4 0.1 2.2 2 1 1 3 3 3 0 Fatty acid synthase type I helical domain XRN_M PF17846.1 ETO13961.1 - 1.8e-20 73.3 0.0 1.8e-20 73.3 0.0 2.9 2 1 0 3 3 3 1 Xrn1 helical domain EF-hand_12 PF17901.1 ETO13961.1 - 0.042 14.3 0.7 0.36 11.3 0.1 2.6 3 0 0 3 3 3 0 EF-hand fold domain SR-25 PF10500.9 ETO13962.1 - 0.95 9.0 12.2 0.06 12.9 5.3 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein PDCD2_C PF04194.13 ETO13962.1 - 6.4 6.8 6.9 15 5.6 2.3 2.4 2 1 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain Secretin_N_2 PF07655.13 ETO13963.1 - 0.63 10.6 10.1 0.1 13.1 6.3 1.7 2 0 0 2 2 2 0 Secretin N-terminal domain Glucos_trans_II PF14264.6 ETO13966.1 - 0.06 12.7 7.1 0.073 12.4 3.5 2.2 2 0 0 2 2 2 0 Glucosyl transferase GtrII G6B PF15096.6 ETO13966.1 - 0.1 12.4 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 G6B family DUF5383 PF17355.2 ETO13966.1 - 1.2 9.5 7.0 5 7.5 0.0 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5383) Choline_transpo PF04515.12 ETO13968.1 - 1.3e-30 106.7 22.1 1.7e-15 57.1 3.7 2.1 1 1 1 2 2 2 2 Plasma-membrane choline transporter TM_helix PF05552.12 ETO13968.1 - 0.027 14.4 2.7 0.14 12.2 0.1 2.8 2 1 1 3 3 3 0 Conserved TM helix SMP_LBD PF17047.5 ETO13968.1 - 0.067 12.7 0.1 0.12 11.9 0.1 1.3 1 0 0 1 1 1 0 Synaptotagmin-like mitochondrial-lipid-binding domain Gly-zipper_Omp PF13488.6 ETO13968.1 - 0.37 10.8 2.6 0.21 11.6 0.4 1.6 2 0 0 2 2 2 0 Glycine zipper DUF5592 PF17332.2 ETO13969.1 - 0.16 12.6 3.5 0.35 11.5 3.5 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5592) PapA_C PF16911.5 ETO13970.1 - 0.0025 17.9 0.0 0.0043 17.1 0.0 1.5 1 0 0 1 1 1 1 Phthiocerol/phthiodiolone dimycocerosyl transferase C-terminus Spem1 PF15670.5 ETO13970.1 - 0.072 12.7 1.6 0.12 11.9 1.6 1.3 1 0 0 1 1 1 0 Spermatid maturation protein 1 Tox-REase-2 PF15646.6 ETO13970.1 - 0.13 12.4 0.7 1.2 9.3 0.5 2.1 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 2 Cupin_8 PF13621.6 ETO13971.1 - 1.1e-08 35.1 1.2 2.5e-07 30.7 0.4 2.3 1 1 1 2 2 2 1 Cupin-like domain JmjC PF02373.22 ETO13971.1 - 1.9e-08 34.7 0.4 7.9e-05 23.1 0.0 2.7 3 0 0 3 3 3 2 JmjC domain, hydroxylase Cupin_4 PF08007.12 ETO13971.1 - 0.00064 19.3 0.0 0.0011 18.5 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein C2 PF00168.30 ETO13972.1 - 4.9e-10 39.6 0.1 1.4e-09 38.2 0.1 1.8 1 0 0 1 1 1 1 C2 domain Spc7 PF08317.11 ETO13972.1 - 0.0048 15.8 22.3 0.0048 15.8 22.3 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein DivIC PF04977.15 ETO13972.1 - 0.0057 16.4 3.2 0.0057 16.4 3.2 4.1 1 1 3 4 4 4 2 Septum formation initiator SlyX PF04102.12 ETO13972.1 - 0.021 15.4 9.1 0.021 15.4 9.1 3.6 1 1 2 3 3 2 0 SlyX HAP1_N PF04849.13 ETO13972.1 - 0.022 14.0 30.8 0.03 13.5 30.8 1.1 1 0 0 1 1 1 0 HAP1 N-terminal conserved region GAS PF13851.6 ETO13972.1 - 0.04 13.3 33.5 0.039 13.3 6.6 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CALCOCO1 PF07888.11 ETO13972.1 - 0.12 11.2 29.0 0.18 10.7 29.0 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Nup88 PF10168.9 ETO13972.1 - 0.22 9.3 22.1 0.29 8.9 22.1 1.1 1 0 0 1 1 1 0 Nuclear pore component ATG16 PF08614.11 ETO13972.1 - 0.6 10.3 35.6 2.3 8.4 21.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) SYCE1 PF15233.6 ETO13972.1 - 0.93 9.5 32.6 0.097 12.7 19.3 2.1 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 BRE1 PF08647.11 ETO13972.1 - 1.1 9.4 32.6 0.4 10.8 5.9 3.2 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase Atg14 PF10186.9 ETO13972.1 - 1.2 8.2 29.6 0.17 10.9 5.5 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 KxDL PF10241.9 ETO13972.1 - 1.3 9.3 24.6 3.5 8.0 13.6 2.5 1 1 0 2 2 2 0 Uncharacterized conserved protein DUF2935 PF11155.8 ETO13972.1 - 1.4 9.3 10.0 0.17 12.2 2.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) ERM PF00769.19 ETO13972.1 - 1.5 8.6 36.5 11 5.8 36.5 1.9 1 1 0 1 1 1 0 Ezrin/radixin/moesin family PRKG1_interact PF15898.5 ETO13972.1 - 1.9 9.5 30.5 0.19 12.7 4.3 3.2 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Uso1_p115_C PF04871.13 ETO13972.1 - 2 8.8 34.5 0.68 10.3 17.4 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region CENP-F_leu_zip PF10473.9 ETO13972.1 - 2.9 7.9 35.5 0.4 10.7 23.7 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3450 PF11932.8 ETO13972.1 - 3.6 6.8 33.9 0.79 9.0 16.6 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) DUF4407 PF14362.6 ETO13972.1 - 4.4 6.6 25.5 0.31 10.4 18.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) GPS2_interact PF15784.5 ETO13972.1 - 5.6 7.5 26.1 2.1 8.8 3.8 3.4 3 0 0 3 3 3 0 G-protein pathway suppressor 2-interacting domain Syntaxin-6_N PF09177.11 ETO13972.1 - 5.6 7.6 21.5 1.2 9.7 10.1 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF489 PF04356.12 ETO13972.1 - 7.9 6.4 12.2 11 6.0 10.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Rootletin PF15035.6 ETO13972.1 - 8.1 6.4 31.4 4.2 7.4 7.6 2.3 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion Sec34 PF04136.15 ETO13972.1 - 8.2 6.3 24.2 4.7 7.1 8.4 2.4 2 1 0 2 2 2 0 Sec34-like family V-SNARE_C PF12352.8 ETO13972.1 - 9 6.7 12.3 1.1 9.6 1.6 3.1 1 1 2 3 3 3 0 Snare region anchored in the vesicle membrane C-terminus CENP-H PF05837.12 ETO13972.1 - 9.9 6.6 30.4 0.3 11.5 7.6 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) NCD3G PF07562.14 ETO13973.1 - 6.5 6.8 12.2 0.044 13.7 2.9 2.3 2 0 0 2 2 2 0 Nine Cysteines Domain of family 3 GPCR FPL PF09758.9 ETO13974.1 - 0.00088 19.3 0.1 0.00088 19.3 0.1 2.0 2 0 0 2 2 2 1 Uncharacterised conserved protein ATG2_CAD PF13329.6 ETO13975.1 - 2.8e-06 27.1 0.0 0.091 12.5 0.0 2.5 2 0 0 2 2 2 2 Autophagy-related protein 2 CAD motif fn3 PF00041.21 ETO13976.1 - 0.016 15.6 2.5 0.53 10.7 0.7 3.1 2 1 0 2 2 2 0 Fibronectin type III domain CobU PF02283.16 ETO13976.1 - 0.063 12.8 3.9 0.12 11.9 3.9 1.4 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase Apolipoprotein PF01442.18 ETO13976.1 - 0.15 11.9 10.3 0.32 10.9 10.0 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain FUSC-like PF12805.7 ETO13976.1 - 0.33 10.0 1.7 0.5 9.4 1.0 1.6 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS DUF1515 PF07439.11 ETO13976.1 - 0.62 10.1 3.9 1.7 8.7 3.9 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF3810 PF12725.7 ETO13976.1 - 1.2 8.4 5.4 2.8 7.2 5.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Allexi_40kDa PF05549.11 ETO13976.1 - 7 6.1 6.9 2.6 7.5 3.4 1.9 1 1 1 2 2 2 0 Allexivirus 40kDa protein YpjP PF14005.6 ETO13977.1 - 0.015 15.4 0.3 0.04 14.0 0.3 1.8 1 0 0 1 1 1 0 YpjP-like protein NOA36 PF06524.12 ETO13977.1 - 3.9 6.7 10.1 0.22 10.8 3.6 2.0 2 0 0 2 2 2 0 NOA36 protein XK-related PF09815.9 ETO13978.1 - 4.5e-05 22.7 0.6 4.5e-05 22.7 0.6 2.1 2 1 0 2 2 2 1 XK-related protein EB1_binding PF05937.11 ETO13978.1 - 0.098 13.3 0.0 0.19 12.3 0.0 1.4 1 0 0 1 1 1 0 EB-1 Binding Domain TPR_12 PF13424.6 ETO13979.1 - 8.2e-16 58.1 17.5 0.00011 22.4 2.9 6.1 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13979.1 - 1.8e-14 52.6 22.1 0.061 13.5 0.0 9.4 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO13979.1 - 2.6e-14 52.6 10.9 0.0064 16.2 0.1 7.2 8 0 0 8 8 8 3 TPR repeat TPR_14 PF13428.6 ETO13979.1 - 7.8e-13 48.1 0.6 0.25 12.3 0.0 6.7 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO13979.1 - 1.2e-11 45.1 4.0 0.00078 20.0 0.0 5.6 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13979.1 - 4.1e-11 42.2 33.0 0.0019 17.9 0.7 9.4 9 1 0 9 9 9 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO13979.1 - 9.1e-09 35.1 18.1 0.26 11.8 0.0 8.6 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO13979.1 - 3.8e-07 30.5 6.1 1.7 9.2 0.0 5.9 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO13979.1 - 6.6e-07 29.0 19.8 0.065 13.5 0.7 7.6 9 0 0 9 9 8 2 Tetratricopeptide repeat Zip PF02535.22 ETO13979.1 - 0.00076 18.8 1.0 0.00076 18.8 1.0 1.8 2 0 0 2 2 2 1 ZIP Zinc transporter TPR_7 PF13176.6 ETO13979.1 - 0.0013 18.6 7.2 3.3 7.9 0.0 6.1 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO13979.1 - 0.0034 17.2 7.4 23 5.0 0.0 6.6 7 0 0 7 7 7 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO13979.1 - 0.01 16.4 9.5 29 5.6 0.2 5.4 5 0 0 5 5 4 0 Tetratricopeptide repeat Tmemb_18A PF09771.9 ETO13979.1 - 0.013 15.9 0.4 0.032 14.6 0.4 1.6 1 0 0 1 1 1 0 Transmembrane protein 188 TPR_MalT PF17874.1 ETO13979.1 - 0.049 13.0 8.6 0.32 10.3 0.2 3.5 3 0 0 3 3 3 0 MalT-like TPR region TPR_9 PF13371.6 ETO13979.1 - 0.054 13.6 0.0 2.2 8.5 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Phenyl_P_gamma PF09662.10 ETO13979.1 - 0.089 13.0 0.0 0.27 11.4 0.0 1.8 1 0 0 1 1 1 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) ANAPC3 PF12895.7 ETO13979.1 - 0.44 10.8 0.0 0.44 10.8 0.0 5.4 6 1 1 7 7 6 0 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ETO13979.1 - 0.48 10.5 4.2 13 5.9 0.1 4.0 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 ETO13980.1 - 2e-10 40.2 6.1 0.00015 21.3 3.0 2.5 2 0 0 2 2 2 2 TPR repeat TPR_17 PF13431.6 ETO13980.1 - 2.9e-07 30.4 2.6 0.46 11.0 0.1 4.1 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO13980.1 - 0.0034 18.1 0.2 0.38 11.7 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO13980.1 - 0.0036 17.9 1.4 0.0075 16.9 1.4 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO13980.1 - 0.0042 17.6 1.0 0.48 11.0 0.1 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO13980.1 - 0.0084 15.9 9.7 4.1 7.4 0.9 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO13980.1 - 0.01 15.9 8.5 0.091 12.9 0.8 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO13980.1 - 0.047 14.0 1.2 2.4 8.5 0.0 2.5 1 1 2 3 3 3 0 Tetratricopeptide repeat Ocular_alb PF02101.15 ETO13981.1 - 0.22 10.4 2.3 0.37 9.7 2.3 1.3 1 0 0 1 1 1 0 Ocular albinism type 1 protein PCNP PF15473.6 ETO13981.1 - 2.7 8.7 10.0 0.88 10.3 7.0 1.6 2 0 0 2 2 2 0 PEST, proteolytic signal-containing nuclear protein family RhoGEF PF00621.20 ETO13982.1 - 6.6e-06 26.5 4.4 1.1e-05 25.7 4.4 1.4 1 1 0 1 1 1 1 RhoGEF domain DUF815 PF05673.13 ETO13982.1 - 0.023 13.9 0.1 0.03 13.5 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PHD_2 PF13831.6 ETO13982.1 - 0.038 13.5 0.4 0.075 12.6 0.4 1.4 1 0 0 1 1 1 0 PHD-finger Secretin_N_2 PF07655.13 ETO13983.1 - 0.7 10.5 24.4 1.7 9.2 24.4 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain Spt5_N PF11942.8 ETO13983.1 - 5.9 7.9 16.0 11 7.1 1.1 2.3 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal ALMT PF11744.8 ETO13983.1 - 7.2 5.3 16.9 12 4.6 16.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Met_10 PF02475.16 ETO13984.1 - 4.3e-53 180.0 0.0 6.4e-53 179.5 0.0 1.3 1 0 0 1 1 1 1 Met-10+ like-protein DDHD PF02862.17 ETO13984.1 - 0.012 15.8 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 0 DDHD domain Ctr PF04145.15 ETO13984.1 - 0.046 14.3 0.0 0.078 13.6 0.0 1.3 1 0 0 1 1 1 0 Ctr copper transporter family HCO3_cotransp PF00955.21 ETO13984.1 - 0.93 8.2 5.0 1.4 7.7 5.0 1.1 1 0 0 1 1 1 0 HCO3- transporter family DUF2076 PF09849.9 ETO13984.1 - 8.9 6.3 7.3 14 5.6 7.3 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-TRAF PF02176.18 ETO13986.1 - 0.0013 19.3 4.2 0.0026 18.4 3.2 1.9 1 1 1 2 2 2 1 TRAF-type zinc finger CDO_I PF05995.12 ETO13986.1 - 0.09 12.1 0.0 0.097 12.0 0.0 1.1 1 0 0 1 1 1 0 Cysteine dioxygenase type I FTA4 PF13093.6 ETO13987.1 - 0.024 14.5 5.9 0.036 14.0 5.9 1.3 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 Fez1 PF06818.15 ETO13987.1 - 0.038 14.5 13.6 0.058 13.9 13.6 1.2 1 0 0 1 1 1 0 Fez1 HMMR_N PF15905.5 ETO13987.1 - 0.056 12.9 17.0 0.089 12.2 17.0 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Phage_GPO PF05929.11 ETO13987.1 - 0.081 12.5 4.5 0.11 12.1 4.5 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF4639 PF15479.6 ETO13987.1 - 0.12 11.3 0.9 0.14 11.0 0.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) DUF740 PF05340.12 ETO13987.1 - 0.14 10.9 4.9 0.18 10.6 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Spc7 PF08317.11 ETO13987.1 - 0.4 9.5 16.4 0.64 8.9 16.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein FAM76 PF16046.5 ETO13987.1 - 0.61 9.4 9.0 0.83 8.9 9.0 1.2 1 0 0 1 1 1 0 FAM76 protein Cep57_CLD_2 PF14197.6 ETO13987.1 - 0.78 9.9 11.5 2.4 8.3 11.5 1.9 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 Exonuc_VII_L PF02601.15 ETO13987.1 - 0.91 9.0 5.7 1.2 8.6 5.7 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit VPS38 PF17649.1 ETO13987.1 - 1.1 8.1 11.6 1.6 7.5 11.6 1.2 1 0 0 1 1 1 0 Vacuolar protein sorting 38 DUF16 PF01519.16 ETO13987.1 - 1.9 9.0 13.3 6.6 7.3 13.3 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF16 Atg14 PF10186.9 ETO13987.1 - 3.4 6.7 13.4 6.1 5.8 13.4 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3450 PF11932.8 ETO13987.1 - 4.6 6.5 12.1 6.9 5.9 12.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Fib_alpha PF08702.10 ETO13987.1 - 5.1 7.3 15.0 6.9 6.9 13.5 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF1664 PF07889.12 ETO13987.1 - 5.4 7.1 10.6 6.3 6.9 8.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ETO13987.1 - 8.1 5.7 9.0 13 5.1 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) U-box PF04564.15 ETO13988.1 - 1.6e-23 82.6 1.4 3.2e-23 81.7 0.4 2.1 2 0 0 2 2 2 1 U-box domain ZZ PF00569.17 ETO13989.1 - 3.5e-05 23.5 4.8 0.00011 21.9 1.0 2.6 2 0 0 2 2 2 1 Zinc finger, ZZ type C1_2 PF03107.16 ETO13989.1 - 0.18 12.1 3.5 0.2 12.0 0.3 2.6 2 0 0 2 2 2 0 C1 domain Peptidase_S7 PF00949.21 ETO13989.1 - 0.79 9.5 3.4 18 5.2 0.1 2.7 2 0 0 2 2 2 0 Peptidase S7, Flavivirus NS3 serine protease zf-Di19 PF05605.12 ETO13990.1 - 1.6e-05 25.1 2.9 4.3e-05 23.7 2.9 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding ZZ PF00569.17 ETO13990.1 - 0.49 10.3 14.2 0.12 12.2 10.6 1.9 2 0 0 2 2 2 0 Zinc finger, ZZ type Peptidase_C14 PF00656.22 ETO13991.1 - 0.0055 16.7 1.2 0.014 15.4 0.2 2.2 1 1 0 1 1 1 1 Caspase domain Toxin_21 PF08091.11 ETO13991.1 - 0.016 15.1 1.6 0.016 15.1 1.6 1.7 2 0 0 2 2 2 0 Spider insecticidal peptide XPG_I PF00867.18 ETO13991.1 - 1 9.8 3.4 1.2 9.5 0.0 2.6 3 0 0 3 3 3 0 XPG I-region ASH PF15780.5 ETO13992.1 - 6e-10 39.2 2.2 2.9e-05 24.2 0.5 4.4 3 2 1 4 4 4 1 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 ETO13992.1 - 3e-07 30.3 7.6 0.019 14.8 0.1 3.8 3 1 1 4 4 4 3 MSP (Major sperm protein) domain TMEM131_like PF12371.8 ETO13992.1 - 0.0013 19.0 0.9 0.44 10.8 0.2 2.9 3 0 0 3 3 3 2 Transmembrane protein 131-like MYCBPAP PF14646.6 ETO13992.1 - 0.011 14.7 0.1 0.6 9.0 0.1 2.5 2 1 0 2 2 2 0 MYCBP-associated protein family Vault_3 PF17795.1 ETO13992.1 - 0.084 12.9 0.2 13 5.9 0.0 3.1 1 1 1 2 2 2 0 Major Vault Protein Repeat domain Myotoxins PF00819.17 ETO13992.1 - 0.47 10.8 0.1 0.47 10.8 0.1 2.7 4 0 0 4 4 4 0 Myotoxin, crotamine ETRAMP PF09716.10 ETO13993.1 - 0.75 9.9 4.6 3.4 7.8 4.6 2.0 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) WBP-1 PF11669.8 ETO13993.1 - 0.9 10.2 0.1 0.9 10.2 0.1 2.7 2 1 1 3 3 3 0 WW domain-binding protein 1 AP3D1 PF06375.11 ETO13993.1 - 1.6 8.9 10.8 0.58 10.4 7.9 1.6 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Radial_spoke PF04712.12 ETO13994.1 - 0.001 18.1 4.2 0.0013 17.8 4.2 1.1 1 0 0 1 1 1 1 Radial spokehead-like protein Sigma70_ner PF04546.13 ETO13994.1 - 0.005 16.7 2.1 0.008 16.1 2.1 1.3 1 0 0 1 1 1 1 Sigma-70, non-essential region ASC PF00858.24 ETO13994.1 - 0.0071 15.4 0.1 0.0075 15.3 0.1 1.1 1 0 0 1 1 1 1 Amiloride-sensitive sodium channel Myc_N PF01056.18 ETO13994.1 - 0.01 15.8 0.2 0.012 15.5 0.2 1.3 1 0 0 1 1 1 0 Myc amino-terminal region PBP1_TM PF14812.6 ETO13994.1 - 0.026 14.9 4.6 0.027 14.8 1.0 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 ETO13994.1 - 0.048 11.9 1.9 0.054 11.8 1.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 ETO13994.1 - 0.067 13.2 5.4 0.1 12.7 5.4 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF2457 PF10446.9 ETO13994.1 - 0.068 12.3 8.9 0.085 12.0 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BT1 PF03092.16 ETO13994.1 - 0.068 11.4 0.0 0.078 11.2 0.0 1.2 1 0 0 1 1 1 0 BT1 family RNA_pol_3_Rpc31 PF11705.8 ETO13994.1 - 0.1 12.8 9.0 0.17 12.1 9.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF913 PF06025.12 ETO13994.1 - 0.13 11.2 0.0 0.18 10.8 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM176 PF14851.6 ETO13994.1 - 0.17 11.6 5.5 0.26 10.9 5.5 1.3 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.12 ETO13994.1 - 0.31 10.4 8.8 0.49 9.8 8.8 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO13994.1 - 0.56 8.4 10.8 0.69 8.1 10.8 1.1 1 0 0 1 1 1 0 Nop14-like family RPN2_C PF18004.1 ETO13994.1 - 0.62 10.0 4.5 1 9.3 4.5 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Sporozoite_P67 PF05642.11 ETO13994.1 - 0.66 8.0 2.1 0.77 7.8 2.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen BSP_II PF05432.11 ETO13994.1 - 0.75 9.4 18.3 1 9.0 18.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CobT PF06213.12 ETO13994.1 - 1.3 8.3 8.8 1.7 8.0 8.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT HSP90 PF00183.18 ETO13994.1 - 1.7 7.5 6.3 2.1 7.1 6.3 1.1 1 0 0 1 1 1 0 Hsp90 protein S-antigen PF05756.11 ETO13994.1 - 2.8 8.4 6.8 6.5 7.2 6.8 1.6 1 0 0 1 1 1 0 S-antigen protein Pox_Ag35 PF03286.14 ETO13994.1 - 5.6 6.7 10.3 8.5 6.1 10.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 ETO13994.1 - 8.2 6.9 16.6 12 6.3 16.6 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pes-10 PF07149.11 ETO13994.1 - 9.2 5.2 9.0 12 4.9 9.0 1.1 1 0 0 1 1 1 0 Pes-10 RGS PF00615.19 ETO13995.1 - 6.9e-08 32.8 3.6 7.3e-07 29.5 3.6 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain PIP49_N PF14875.6 ETO13995.1 - 0.023 14.6 0.2 0.11 12.3 0.1 2.2 1 1 0 1 1 1 0 N-term cysteine-rich ER, FAM69 Glyco_H_20C_C PF18088.1 ETO13995.1 - 0.027 14.3 0.4 0.071 13.0 0.2 1.7 1 1 0 1 1 1 0 Glycoside Hydrolase 20C C-terminal domain Zip PF02535.22 ETO13995.1 - 0.087 12.0 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sporozoite_P67 PF05642.11 ETO13995.1 - 1.2 7.1 7.4 1.8 6.6 7.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ETO13995.1 - 10 5.4 16.7 17 4.6 16.7 1.3 1 0 0 1 1 1 0 NOA36 protein HtrL_YibB PF09612.10 ETO13996.1 - 9.6e-10 38.4 3.5 1.5e-09 37.8 3.5 1.3 1 0 0 1 1 1 1 Bacterial protein of unknown function (HtrL_YibB) 7TM-7TMR_HD PF07698.11 ETO13996.1 - 0.061 13.1 0.1 0.087 12.6 0.1 1.2 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase cNMP_binding PF00027.29 ETO13997.1 - 4.2e-17 62.0 0.0 4.3e-16 58.8 0.0 2.4 3 0 0 3 3 3 1 Cyclic nucleotide-binding domain Pkinase PF00069.25 ETO13997.1 - 2.5e-06 27.1 0.0 4.4e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 ETO13998.1 - 8.3e-26 89.9 0.2 6.7e-11 42.1 0.0 3.2 2 1 1 3 3 3 3 Cyclic nucleotide-binding domain Baculo_p24 PF05073.12 ETO14000.1 - 0.11 12.2 0.1 0.17 11.6 0.1 1.2 1 0 0 1 1 1 0 Baculovirus P24 capsid protein RIO1 PF01163.22 ETO14001.1 - 2.8e-21 76.0 2.7 2.8e-21 76.0 2.7 3.3 3 1 0 3 3 3 1 RIO1 family DUF2164 PF09932.9 ETO14001.1 - 0.023 14.7 1.0 0.05 13.7 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) BUD22 PF09073.10 ETO14001.1 - 7.1 5.9 45.2 0.62 9.3 11.4 2.1 2 0 0 2 2 2 0 BUD22 Myb_DNA-binding PF00249.31 ETO14002.1 - 6.5e-10 39.0 0.3 9.1e-10 38.6 0.3 1.3 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO14002.1 - 3.1e-06 27.3 0.4 5e-06 26.7 0.4 1.4 1 1 0 1 1 1 1 Myb-like DNA-binding domain ZZ PF00569.17 ETO14002.1 - 0.011 15.5 0.9 0.02 14.7 0.9 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type SLIDE PF09111.10 ETO14002.1 - 0.015 15.3 1.9 0.041 13.9 2.0 1.7 1 1 0 1 1 1 0 SLIDE DUF4195 PF13836.6 ETO14004.1 - 6.3 6.9 10.6 0.15 12.2 2.4 2.3 2 2 0 2 2 2 0 Domain of unknown function (DUF4195) PH PF00169.29 ETO14005.1 - 7e-06 26.5 13.7 0.00021 21.8 0.1 3.2 3 1 0 3 3 3 2 PH domain DUF1799 PF08809.11 ETO14005.1 - 0.13 12.5 2.6 0.47 10.7 2.1 2.3 1 1 0 1 1 1 0 Phage related hypothetical protein (DUF1799) Endostatin PF06482.11 ETO14007.1 - 0.0016 18.0 2.2 0.018 14.5 0.2 2.3 2 0 0 2 2 2 1 Collagenase NC10 and Endostatin HypD PF01924.16 ETO14007.1 - 0.091 11.8 0.4 0.26 10.3 0.1 1.8 2 0 0 2 2 2 0 Hydrogenase formation hypA family Zip PF02535.22 ETO14007.1 - 0.22 10.7 0.2 0.38 9.9 0.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 ETO14007.1 - 0.95 8.1 2.9 2.4 6.8 2.9 1.6 1 0 0 1 1 1 0 Ureide permease FAM176 PF14851.6 ETO14007.1 - 1.4 8.6 6.8 0.92 9.2 4.4 2.0 2 0 0 2 2 2 0 FAM176 family PMSR PF01625.21 ETO14008.1 - 0.044 14.0 0.0 0.088 13.0 0.0 1.5 1 0 0 1 1 1 0 Peptide methionine sulfoxide reductase AAA_7 PF12775.7 ETO14009.1 - 0.00028 20.5 0.0 0.00066 19.2 0.0 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region ATPase_2 PF01637.18 ETO14009.1 - 0.0004 20.4 4.1 0.0004 20.4 4.1 1.8 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ETO14009.1 - 0.00068 20.2 0.9 0.0023 18.5 0.4 2.1 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ETO14009.1 - 0.0013 19.1 0.1 0.0049 17.3 0.0 2.0 3 0 0 3 3 2 1 AAA ATPase domain AAA_14 PF13173.6 ETO14009.1 - 0.0031 17.6 6.1 0.0068 16.4 4.0 2.6 2 1 0 2 2 2 1 AAA domain PduV-EutP PF10662.9 ETO14009.1 - 0.012 15.3 0.0 0.086 12.6 0.1 2.1 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation LMBR1 PF04791.16 ETO14009.1 - 0.02 13.8 3.0 0.027 13.4 3.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein RsgA_GTPase PF03193.16 ETO14009.1 - 0.026 14.4 0.6 0.059 13.3 0.0 1.9 2 1 0 2 2 1 0 RsgA GTPase AAA_28 PF13521.6 ETO14009.1 - 0.029 14.6 0.2 0.42 10.9 0.1 2.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO14009.1 - 0.039 14.2 0.0 0.095 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain PPL5 PF18168.1 ETO14009.1 - 0.056 12.7 3.0 0.1 11.9 3.0 1.3 1 0 0 1 1 1 0 Prim-pol family 5 Presenilin PF01080.17 ETO14009.1 - 0.12 11.1 0.6 0.18 10.5 0.6 1.2 1 0 0 1 1 1 0 Presenilin CobA_CobO_BtuR PF02572.15 ETO14009.1 - 0.18 12.1 5.0 0.068 13.4 0.9 2.3 3 0 0 3 3 3 0 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP Pro_CA PF00484.19 ETO14009.1 - 0.31 11.3 1.4 1.6 9.0 0.4 2.3 2 0 0 2 2 2 0 Carbonic anhydrase RasGAP PF00616.19 ETO14009.1 - 0.32 10.7 5.2 0.75 9.5 5.2 1.6 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase AAA_19 PF13245.6 ETO14009.1 - 0.35 11.2 2.0 1.9 8.8 1.3 2.5 2 1 0 2 2 1 0 AAA domain AAA_5 PF07728.14 ETO14009.1 - 0.38 10.7 3.3 1.5 8.8 3.3 2.1 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO14009.1 - 0.39 11.1 6.8 0.95 9.9 5.6 2.4 2 1 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) DUF1943 PF09172.11 ETO14009.1 - 1.3 8.2 6.7 1 8.6 4.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) DUF3987 PF13148.6 ETO14009.1 - 2.3 7.1 7.4 16 4.4 6.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) RR_TM4-6 PF06459.12 ETO14009.1 - 3.6 7.3 13.9 7.7 6.3 13.9 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2252 PF10009.9 ETO14009.1 - 4.8 6.1 9.2 9.6 5.1 9.1 1.5 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) MAS20 PF02064.15 ETO14009.1 - 5.4 7.1 9.6 15 5.7 9.6 1.7 1 0 0 1 1 1 0 MAS20 protein import receptor Endonuc_Holl PF10107.9 ETO14009.1 - 6.3 6.6 13.3 1.9 8.3 7.4 2.6 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase DUF5401 PF17380.2 ETO14009.1 - 8.4 4.3 20.2 13 3.7 20.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) Chromo PF00385.24 ETO14010.1 - 1.1e-11 44.4 0.5 2.5e-11 43.3 0.5 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain HEAT_EZ PF13513.6 ETO14012.1 - 0.0043 17.5 0.0 0.049 14.2 0.0 2.5 3 0 0 3 3 3 1 HEAT-like repeat Fanconi_C PF02106.15 ETO14012.1 - 0.005 15.6 0.1 0.0066 15.2 0.1 1.1 1 0 0 1 1 1 1 Fanconi anaemia group C protein TAF6_C PF07571.13 ETO14012.1 - 0.035 14.4 0.0 0.085 13.2 0.0 1.9 1 1 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain XPC-binding PF09280.11 ETO14012.1 - 0.18 11.5 0.2 17 5.3 0.1 2.3 2 0 0 2 2 2 0 XPC-binding domain Cyt-b5 PF00173.28 ETO14013.1 - 4.8e-22 77.9 0.0 7.8e-22 77.2 0.0 1.3 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain CLP1_P PF16575.5 ETO14015.1 - 7.1e-22 78.1 0.0 1.2e-21 77.3 0.0 1.4 1 0 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 ETO14015.1 - 2.6e-11 43.6 0.0 4.5e-11 42.8 0.0 1.4 1 0 0 1 1 1 1 N-terminal beta-sandwich domain of polyadenylation factor GTP_EFTU PF00009.27 ETO14015.1 - 0.0039 16.7 0.3 0.0082 15.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 ETO14015.1 - 0.0053 17.3 0.1 0.015 15.8 0.0 1.7 1 1 1 2 2 2 1 ABC transporter MMR_HSR1 PF01926.23 ETO14015.1 - 0.0053 16.8 0.0 0.0092 16.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_24 PF13479.6 ETO14015.1 - 0.0056 16.4 0.0 0.0085 15.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 ETO14015.1 - 0.021 14.2 0.0 0.029 13.7 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family DUF87 PF01935.17 ETO14015.1 - 0.024 14.7 0.0 0.043 13.9 0.0 1.3 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_16 PF13191.6 ETO14015.1 - 0.037 14.4 0.0 0.096 13.1 0.0 1.7 1 1 1 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ETO14015.1 - 0.056 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain TniB PF05621.11 ETO14015.1 - 0.1 12.0 0.0 0.27 10.6 0.0 1.7 1 1 1 2 2 2 0 Bacterial TniB protein PduV-EutP PF10662.9 ETO14015.1 - 0.12 12.1 0.0 0.19 11.5 0.0 1.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RNA_helicase PF00910.22 ETO14015.1 - 0.17 12.3 0.0 0.42 11.0 0.0 1.7 2 0 0 2 2 1 0 RNA helicase G-alpha PF00503.20 ETO14015.1 - 0.18 10.9 0.2 0.23 10.6 0.2 1.1 1 0 0 1 1 1 0 G-protein alpha subunit AAA_23 PF13476.6 ETO14015.1 - 0.18 12.3 4.4 0.29 11.6 0.0 2.1 1 1 1 2 2 2 0 AAA domain MBT PF02820.18 ETO14017.1 - 0.0011 19.2 0.2 0.0026 18.1 0.2 1.6 1 0 0 1 1 1 1 mbt repeat Tudor-knot PF11717.8 ETO14017.1 - 0.054 13.4 0.7 0.11 12.4 0.7 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain HAD_SAK_2 PF18143.1 ETO14018.1 - 8.1e-15 55.4 3.3 2.4e-13 50.6 1.8 2.9 2 1 0 2 2 2 1 HAD domain in Swiss Army Knife RNA repair proteins CobT PF06213.12 ETO14018.1 - 0.022 14.1 6.2 0.035 13.5 6.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT BNIP2 PF12496.8 ETO14018.1 - 0.043 14.3 0.9 0.066 13.7 0.9 1.2 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 OMP_b-brl_2 PF13568.6 ETO14019.1 - 0.014 15.4 4.8 0.014 15.4 4.8 3.6 4 0 0 4 4 4 0 Outer membrane protein beta-barrel domain CDC27 PF09507.10 ETO14019.1 - 1.2 8.4 44.0 2.3 7.5 5.8 2.3 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 DUF1104 PF06518.11 ETO14020.1 - 0.0082 16.5 0.1 0.015 15.7 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1104) UCH PF00443.29 ETO14021.1 - 6.1e-36 124.2 5.9 1e-35 123.5 3.0 2.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO14021.1 - 3.2e-29 102.5 4.7 3.2e-29 102.5 4.7 3.1 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase EF-hand_6 PF13405.6 ETO14021.1 - 0.013 15.4 0.1 0.1 12.6 0.1 2.6 1 0 0 1 1 1 0 EF-hand domain Imm70 PF15601.6 ETO14021.1 - 0.031 13.8 0.0 0.13 11.8 0.0 2.1 1 0 0 1 1 1 0 Immunity protein 70 EF-hand_7 PF13499.6 ETO14021.1 - 0.032 14.7 1.9 0.15 12.5 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain pair Sigma70_ner PF04546.13 ETO14023.1 - 0.0032 17.4 2.7 0.0032 17.4 2.7 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region RXT2_N PF08595.11 ETO14023.1 - 0.0033 17.5 1.5 0.0035 17.4 1.5 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal FAM176 PF14851.6 ETO14023.1 - 0.0069 16.1 0.9 0.0074 16.0 0.9 1.2 1 0 0 1 1 1 1 FAM176 family CENP-B_dimeris PF09026.10 ETO14023.1 - 0.029 14.8 14.6 0.035 14.5 14.6 1.1 1 0 0 1 1 1 0 Centromere protein B dimerisation domain TRAP_alpha PF03896.16 ETO14023.1 - 0.068 12.4 1.2 0.067 12.4 1.2 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Hus1 PF04005.12 ETO14023.1 - 0.12 11.5 0.2 0.12 11.4 0.2 1.0 1 0 0 1 1 1 0 Hus1-like protein Sporozoite_P67 PF05642.11 ETO14023.1 - 0.24 9.5 1.7 0.23 9.5 1.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen RRN3 PF05327.11 ETO14023.1 - 0.29 9.6 3.4 0.28 9.7 3.4 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2457 PF10446.9 ETO14023.1 - 1.1 8.4 16.4 1.2 8.2 16.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 ETO14023.1 - 1.2 8.9 8.8 1.3 8.8 8.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ETO14023.1 - 1.6 6.9 8.4 1.8 6.8 8.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4637 PF15470.6 ETO14023.1 - 2.6 7.7 8.7 3.2 7.5 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) SDA1 PF05285.12 ETO14023.1 - 4.4 6.6 11.8 5 6.5 11.8 1.0 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 ETO14023.1 - 5 6.4 15.8 6.1 6.1 15.8 1.1 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO14023.1 - 6.5 4.8 12.8 7.2 4.7 12.8 1.0 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 ETO14023.1 - 7.3 6.8 14.5 8.4 6.6 14.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DNA_pol_phi PF04931.13 ETO14023.1 - 7.3 4.5 17.8 8.3 4.4 17.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi Apc15p PF05841.11 ETO14024.1 - 0.29 12.0 13.4 0.48 11.2 13.4 1.3 1 0 0 1 1 1 0 Apc15p protein Secretin_N_2 PF07655.13 ETO14024.1 - 0.69 10.5 18.5 1.2 9.7 18.5 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 ETO14024.1 - 0.84 7.9 9.5 1 7.7 9.5 1.1 1 0 0 1 1 1 0 Menin Sin3a_C PF16879.5 ETO14025.1 - 2.3e-13 50.5 5.4 2.3e-13 50.5 5.4 1.6 2 0 0 2 2 2 1 C-terminal domain of Sin3a protein DUF3439 PF11921.8 ETO14025.1 - 0.2 11.6 19.3 0.48 10.4 19.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Sec16 PF12932.7 ETO14026.1 - 3.6 8.2 6.2 3.6 8.2 1.2 3.0 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region SUKH_6 PF14568.6 ETO14027.1 - 0.0078 16.6 2.9 0.0078 16.6 2.9 1.6 2 0 0 2 2 2 1 SMI1-KNR4 cell-wall Sporozoite_P67 PF05642.11 ETO14027.1 - 0.2 9.7 5.4 0.3 9.1 5.4 1.5 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CNDH2_C PF16858.5 ETO14027.1 - 0.6 9.9 18.7 0.94 9.3 18.7 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term GCIP PF13324.6 ETO14027.1 - 1.2 8.7 7.8 2.3 7.7 7.8 1.5 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting ATF7IP_BD PF16788.5 ETO14028.1 - 0.34 11.0 7.9 0.043 13.9 3.7 1.6 2 0 0 2 2 2 0 ATF-interacting protein binding domain CBFD_NFYB_HMF PF00808.23 ETO14029.1 - 2.7e-13 50.0 1.5 3.3e-13 49.7 0.4 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone HMG_box PF00505.19 ETO14029.1 - 6.5e-10 39.3 0.5 6.5e-10 39.3 0.5 2.1 2 0 0 2 2 2 1 HMG (high mobility group) box Histone PF00125.24 ETO14029.1 - 7.8e-08 32.8 2.1 1.3e-07 32.0 2.1 1.5 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 HMG_box_2 PF09011.10 ETO14029.1 - 2.8e-05 24.6 1.9 6.5e-05 23.4 1.9 1.7 1 0 0 1 1 1 1 HMG-box domain CENP-T_C PF15511.6 ETO14029.1 - 0.014 15.5 0.2 0.03 14.5 0.2 1.5 1 0 0 1 1 1 0 Centromere kinetochore component CENP-T histone fold DUF4872 PF16169.5 ETO14029.1 - 0.096 12.4 1.3 0.14 11.9 0.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4872) WD40 PF00400.32 ETO14030.1 - 2.9e-36 122.9 23.2 6.9e-06 26.7 0.2 8.5 8 1 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO14030.1 - 1.4e-07 30.6 6.7 0.016 13.8 1.8 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14030.1 - 1.2e-06 28.7 0.1 2.5 8.5 0.0 5.3 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO14030.1 - 3.5e-05 24.4 3.2 3.5e-05 24.4 3.2 2.9 3 0 0 3 3 3 1 TRAF-type zinc finger HV_small_capsid PF17086.5 ETO14030.1 - 0.012 15.9 0.7 0.075 13.3 0.1 2.6 2 0 0 2 2 2 0 Small capsid protein of Herpesviridae Ras PF00071.22 ETO14031.1 - 5e-24 84.7 0.1 8.8e-24 83.9 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO14031.1 - 5.7e-20 71.7 0.1 1.1e-19 70.8 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO14031.1 - 9.5e-05 21.9 0.1 0.00015 21.3 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO14031.1 - 0.00016 21.7 0.1 0.00041 20.4 0.0 1.7 1 1 1 2 2 2 1 50S ribosome-binding GTPase Ras PF00071.22 ETO14032.1 - 4.5e-15 55.6 0.2 2.6e-14 53.1 0.2 2.0 1 1 0 1 1 1 1 Ras family Yippee-Mis18 PF03226.14 ETO14033.1 - 3.9e-11 43.1 0.7 3.9e-11 43.1 0.7 2.1 2 1 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly zf-C4H2 PF10146.9 ETO14033.1 - 0.0013 19.1 8.3 0.0019 18.6 8.3 1.2 1 0 0 1 1 1 1 Zinc finger-containing protein APG6_N PF17675.1 ETO14033.1 - 0.0016 19.0 19.7 0.03 14.8 10.9 2.3 1 1 1 2 2 2 1 Apg6 coiled-coil region Lebercilin PF15619.6 ETO14033.1 - 0.0028 17.3 15.2 0.0048 16.6 15.2 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Spc7 PF08317.11 ETO14033.1 - 0.0049 15.8 13.7 0.0071 15.3 13.7 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein BRE1 PF08647.11 ETO14033.1 - 0.0085 16.1 11.9 0.0085 16.1 11.9 2.8 1 1 2 3 3 3 1 BRE1 E3 ubiquitin ligase Jnk-SapK_ap_N PF09744.9 ETO14033.1 - 0.011 16.0 12.6 0.019 15.2 12.6 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 LURAP PF14854.6 ETO14033.1 - 0.015 15.3 2.3 0.038 14.0 2.3 1.8 1 0 0 1 1 1 0 Leucine rich adaptor protein Med3 PF11593.8 ETO14033.1 - 0.018 14.3 8.3 0.025 13.8 8.3 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal FUSC PF04632.12 ETO14033.1 - 0.031 12.8 3.8 0.041 12.4 3.8 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family C1_4 PF07975.12 ETO14033.1 - 0.041 14.1 1.4 0.1 12.8 0.2 2.3 2 0 0 2 2 1 0 TFIIH C1-like domain V_ATPase_I PF01496.19 ETO14033.1 - 0.052 11.5 9.5 0.064 11.2 9.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PI_PP_I PF18363.1 ETO14033.1 - 0.056 13.6 1.3 0.13 12.5 1.2 1.8 1 1 0 1 1 1 0 Phosphoinositide phosphatase insertion domain GFA PF04828.14 ETO14033.1 - 0.078 13.3 7.6 0.57 10.6 0.2 3.6 2 2 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme DUF2982 PF11201.8 ETO14033.1 - 0.088 12.4 2.0 0.15 11.6 2.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2982) Sacchrp_dh_C PF16653.5 ETO14033.1 - 0.12 12.4 2.2 0.17 12.0 2.2 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase C-terminal domain EzrA PF06160.12 ETO14033.1 - 0.12 10.5 11.5 0.19 9.9 11.5 1.2 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA HAP1_N PF04849.13 ETO14033.1 - 0.14 11.4 15.8 0.22 10.7 15.8 1.3 1 0 0 1 1 1 0 HAP1 N-terminal conserved region FapA PF03961.13 ETO14033.1 - 0.52 8.8 9.5 0.79 8.3 9.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMF_TATA_bd PF12325.8 ETO14033.1 - 0.59 10.4 16.5 0.18 12.1 8.9 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4554 PF15091.6 ETO14033.1 - 0.62 8.9 8.6 0.86 8.4 8.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) PI3K_P85_iSH2 PF16454.5 ETO14033.1 - 0.63 9.6 15.7 1.4 8.5 15.7 1.6 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Atg14 PF10186.9 ETO14033.1 - 0.82 8.7 11.7 1.3 8.1 11.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 ETO14033.1 - 1.1 7.1 9.2 1.5 6.7 9.2 1.2 1 0 0 1 1 1 0 Prominin DHR10 PF18595.1 ETO14033.1 - 1.2 9.2 17.5 0.47 10.5 11.5 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain DUF2968 PF11180.8 ETO14033.1 - 1.2 8.7 15.1 1.7 8.2 11.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF2203 PF09969.9 ETO14033.1 - 1.3 9.8 10.1 3 8.6 4.6 2.4 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF812 PF05667.11 ETO14033.1 - 1.5 7.6 20.4 0.81 8.5 18.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) RIG-I_C-RD PF11648.8 ETO14033.1 - 2.1 8.6 9.1 3.6 7.9 0.0 3.6 4 0 0 4 4 4 0 C-terminal domain of RIG-I TolA_bind_tri PF16331.5 ETO14033.1 - 2.3 8.4 11.9 8.6 6.5 4.8 3.0 1 1 2 3 3 3 0 TolA binding protein trimerisation zf_UBZ PF18439.1 ETO14033.1 - 2.7 7.6 6.0 5.6 6.7 0.5 2.8 3 0 0 3 3 2 0 Ubiquitin-Binding Zinc Finger GAS PF13851.6 ETO14033.1 - 4.8 6.5 22.0 70 2.7 23.1 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Exonuc_VII_L PF02601.15 ETO14033.1 - 5.4 6.5 13.2 8.2 5.9 13.1 1.3 1 1 0 1 1 1 0 Exonuclease VII, large subunit Enkurin PF13864.6 ETO14033.1 - 5.8 7.4 17.2 14 6.2 4.0 3.0 1 1 1 2 2 2 0 Calmodulin-binding bZIP_1 PF00170.21 ETO14033.1 - 9.1 6.5 18.6 3.9 7.6 0.6 3.4 2 1 1 3 3 3 0 bZIP transcription factor Lectin_N PF03954.14 ETO14033.1 - 9.4 6.0 13.7 7.9 6.2 5.6 2.4 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Bromodomain PF00439.25 ETO14034.1 - 0.029 14.5 0.2 0.086 12.9 0.2 1.9 1 0 0 1 1 1 0 Bromodomain IRK_N PF08466.10 ETO14035.1 - 0.17 12.1 0.1 0.29 11.3 0.1 1.4 1 0 0 1 1 1 0 Inward rectifier potassium channel N-terminal SAP PF02037.27 ETO14037.1 - 2.8e-05 23.7 0.3 0.00013 21.6 0.0 2.2 2 0 0 2 2 2 1 SAP domain RNase_J_C PF17770.1 ETO14037.1 - 0.12 13.5 3.4 0.13 13.3 0.0 2.8 2 1 0 2 2 2 0 Ribonuclease J C-terminal domain DUF2828 PF11443.8 ETO14039.1 - 0.0011 17.2 4.3 0.0014 16.8 4.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) ApbA_C PF08546.11 ETO14039.1 - 0.051 13.8 0.0 0.099 12.9 0.0 1.4 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA C terminal CDC45 PF02724.14 ETO14039.1 - 3.7 5.7 11.5 4.7 5.4 11.5 1.1 1 0 0 1 1 1 0 CDC45-like protein TAL_FSA PF00923.19 ETO14040.1 - 1.9e-81 273.6 0.5 2.3e-81 273.3 0.5 1.0 1 0 0 1 1 1 1 Transaldolase/Fructose-6-phosphate aldolase RELT PF12606.8 ETO14040.1 - 0.17 10.9 0.2 0.36 9.9 0.2 1.5 1 0 0 1 1 1 0 Tumour necrosis factor receptor superfamily member 19 Orthopox_A5L PF06193.11 ETO14042.1 - 0.073 12.5 0.4 0.097 12.1 0.4 1.2 1 0 0 1 1 1 0 Orthopoxvirus A5L protein-like Flagellin_N PF00669.20 ETO14042.1 - 0.13 12.4 3.3 0.1 12.7 1.8 1.6 1 1 0 1 1 1 0 Bacterial flagellin N-terminal helical region Helicase_C PF00271.31 ETO14043.1 - 1.4e-26 93.0 0.1 2e-26 92.5 0.1 1.2 1 0 0 1 1 1 1 Helicase conserved C-terminal domain tRNA-synt_1b PF00579.25 ETO14043.1 - 0.057 12.7 0.0 0.059 12.7 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) RRM_1 PF00076.22 ETO14044.1 - 0.007 16.2 0.2 0.012 15.4 0.2 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Presenilin PF01080.17 ETO14044.1 - 0.018 13.8 0.0 0.018 13.8 0.0 1.2 1 0 0 1 1 1 0 Presenilin PRP38_assoc PF12871.7 ETO14044.1 - 2.1 9.0 85.1 0.12 13.0 48.3 2.4 1 1 1 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term PA28_beta PF02252.18 ETO14045.1 - 1.2e-42 145.0 0.7 1.2e-42 145.0 0.7 1.9 1 1 1 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETO14045.1 - 0.037 14.1 0.8 0.083 12.9 0.8 1.6 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit ApoLp-III PF07464.11 ETO14045.1 - 0.086 12.9 4.9 3.7 7.7 3.9 2.5 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) CH_2 PF06294.11 ETO14045.1 - 0.18 11.9 1.8 0.44 10.7 0.1 2.5 2 2 1 3 3 3 0 CH-like domain in sperm protein TPR_12 PF13424.6 ETO14046.1 - 1.5e-200 650.0 29.0 4e-22 78.3 0.1 12.0 3 3 11 14 14 14 14 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14046.1 - 8.5e-155 499.2 0.0 2.7e-11 43.0 0.0 16.2 15 1 1 16 16 16 16 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14046.1 - 1.3e-114 369.8 84.5 1.1e-08 34.5 1.0 16.6 16 1 1 17 17 16 16 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14046.1 - 2.1e-113 362.3 14.4 2.5e-07 30.2 0.0 16.3 15 1 1 16 16 16 16 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14046.1 - 3.6e-88 282.5 100.3 9.7e-08 31.6 1.3 16.9 16 1 1 17 17 16 16 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14046.1 - 1.5e-77 249.6 56.3 4.7e-06 26.3 0.6 16.5 15 1 1 16 16 16 16 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14046.1 - 5.8e-54 176.7 17.2 0.0021 18.3 0.0 16.1 15 1 0 15 15 15 10 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14046.1 - 8.8e-43 144.7 0.0 0.0012 19.5 0.0 13.5 11 4 2 13 13 13 9 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO14046.1 - 7.5e-28 97.9 0.0 3.7e-06 26.5 0.0 5.1 1 1 4 5 5 5 5 MalT-like TPR region TPR_14 PF13428.6 ETO14046.1 - 2.3e-26 90.2 0.0 0.37 11.7 0.0 14.4 6 5 9 15 15 14 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO14046.1 - 2.8e-20 72.8 41.9 0.83 9.4 0.3 14.0 10 3 4 14 14 14 10 Domain of unknown function (DUF5113) TPR_6 PF13174.6 ETO14046.1 - 8.6e-19 66.9 13.7 0.35 11.6 0.0 14.3 15 0 0 15 15 15 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO14046.1 - 1e-18 67.6 0.4 0.29 11.7 0.0 9.3 5 3 7 12 12 12 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14046.1 - 9.1e-18 63.7 87.4 0.02 14.6 0.3 20.3 13 8 6 20 20 20 7 TPR repeat SNAP PF14938.6 ETO14046.1 - 2.5e-16 60.0 14.0 0.012 15.1 0.0 7.5 1 1 5 8 8 8 7 Soluble NSF attachment protein, SNAP PPR PF01535.20 ETO14046.1 - 3.5e-16 58.2 44.2 0.39 11.1 0.1 15.8 16 0 0 16 16 16 2 PPR repeat ANAPC3 PF12895.7 ETO14046.1 - 3.7e-12 46.3 32.0 0.058 13.6 1.3 9.7 2 2 5 10 10 10 5 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO14046.1 - 3.3e-10 40.4 19.0 2.5 8.7 0.0 11.3 8 4 3 12 12 12 1 Domain of unknown function (DUF4810) DUF627 PF04781.12 ETO14046.1 - 9.1e-09 35.3 15.4 1.3 9.1 0.0 9.8 8 3 2 10 10 10 2 Protein of unknown function (DUF627) MIT PF04212.18 ETO14046.1 - 2.4e-08 33.9 47.2 0.028 14.5 0.4 13.3 11 2 2 13 13 13 2 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO14046.1 - 2.9e-07 30.4 39.4 1.4 8.6 0.1 11.7 6 4 5 12 12 12 2 26S proteasome subunit RPN7 OrfA PF17495.2 ETO14046.1 - 1.5e-05 25.1 0.0 9.5 6.4 0.0 6.3 5 2 1 7 7 7 0 Vpr-like OrfA TPR_9 PF13371.6 ETO14046.1 - 2.9e-05 24.1 0.0 7.1 6.9 0.0 6.0 5 2 1 7 7 7 0 Tetratricopeptide repeat TPR_21 PF09976.9 ETO14046.1 - 2.9e-05 23.9 4.4 0.42 10.3 0.0 6.2 4 2 1 6 6 6 1 Tetratricopeptide repeat-like domain Vta1_C PF18097.1 ETO14046.1 - 8.6e-05 22.2 0.1 43 3.9 0.0 6.2 6 0 0 6 6 6 0 Vta1 C-terminal domain TPR_5 PF12688.7 ETO14046.1 - 0.00024 21.3 0.1 2.9 8.2 0.0 5.2 4 1 1 5 5 5 1 Tetratrico peptide repeat Pep3_Vps18 PF05131.14 ETO14046.1 - 0.01 15.6 13.0 20 5.0 0.0 8.6 10 1 1 11 11 9 0 Pep3/Vps18/deep orange family DUF3568 PF12092.8 ETO14046.1 - 0.044 13.8 0.2 15 5.6 0.0 4.5 5 0 0 5 5 4 0 Protein of unknown function (DUF3568) HTH_Bact PF18768.1 ETO14046.1 - 0.053 13.1 35.6 16 5.2 0.1 12.0 14 0 0 14 14 12 0 Helix-turn-helix bacterial domain TPR_3 PF07720.12 ETO14046.1 - 0.079 13.0 61.1 0.16 12.0 0.7 13.1 16 0 0 16 16 15 0 Tetratricopeptide repeat FATC PF02260.20 ETO14046.1 - 0.086 12.7 0.2 45 4.0 0.0 4.8 4 0 0 4 4 4 0 FATC domain Clathrin PF00637.20 ETO14046.1 - 0.4 10.5 29.9 8.7 6.2 0.7 8.3 4 3 2 7 7 7 0 Region in Clathrin and VPS Sel1 PF08238.12 ETO14046.1 - 0.57 10.9 31.6 8.5 7.2 0.7 10.3 11 0 0 11 11 9 0 Sel1 repeat bPH_3 PF14470.6 ETO14046.1 - 1.7 9.0 15.4 12 6.4 0.5 6.6 3 2 3 6 6 6 0 Bacterial PH domain WD40 PF00400.32 ETO14047.1 - 9.6e-10 38.9 3.4 0.0021 18.8 0.0 4.2 3 2 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14047.1 - 0.0018 18.6 1.2 3.6 7.9 0.0 3.7 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain RL11D PF11088.8 ETO14047.1 - 0.087 13.1 6.6 1.4 9.2 0.7 3.0 3 0 0 3 3 3 0 Glycoprotein encoding membrane proteins RL5A and RL6 RimK PF08443.11 ETO14048.1 - 1.8e-34 119.0 0.0 1e-33 116.6 0.0 2.2 2 0 0 2 2 2 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ETO14048.1 - 2.1e-12 46.8 0.0 3.9e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain Rimk_N PF18030.1 ETO14048.1 - 0.00075 19.8 0.0 0.56 10.6 0.0 2.4 1 1 0 2 2 2 2 RimK PreATP-grasp domain R2K_3 PF14243.6 ETO14048.1 - 0.02 14.9 0.0 0.037 14.0 0.0 1.4 1 0 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 ATP-grasp_3 PF02655.14 ETO14048.1 - 0.083 12.9 0.0 3.3 7.7 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain TMEM154 PF15102.6 ETO14049.1 - 1e-07 31.9 6.1 1.6e-07 31.3 6.1 1.3 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 ETO14049.1 - 1.2e-05 25.6 5.4 2.2e-05 24.7 5.4 1.5 1 0 0 1 1 1 1 Orf78 (ac78) RIFIN PF02009.16 ETO14049.1 - 0.00015 21.8 1.8 0.00018 21.5 1.8 1.2 1 0 0 1 1 1 1 Rifin DUF2207 PF09972.9 ETO14049.1 - 0.0004 19.3 0.1 0.00052 18.9 0.1 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF5305 PF17231.2 ETO14049.1 - 0.00045 19.7 1.9 0.00068 19.1 1.9 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5305) EVI2A PF05399.11 ETO14049.1 - 0.00049 19.8 2.5 0.00065 19.4 2.5 1.2 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) DUF5383 PF17355.2 ETO14049.1 - 0.00092 19.6 1.7 0.0018 18.6 1.7 1.6 1 0 0 1 1 1 1 Family of unknown function (DUF5383) Shisa PF13908.6 ETO14049.1 - 0.00093 19.5 1.9 0.0018 18.6 1.9 1.4 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF3377 PF11857.8 ETO14049.1 - 0.0025 17.7 2.7 0.005 16.7 2.7 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3377) AMA-1 PF02430.15 ETO14049.1 - 0.0031 16.5 1.9 0.0041 16.2 1.9 1.1 1 0 0 1 1 1 1 Apical membrane antigen 1 LRRC37AB_C PF14914.6 ETO14049.1 - 0.0063 16.4 4.1 0.0098 15.8 4.1 1.3 1 0 0 1 1 1 1 LRRC37A/B like protein 1 C-terminal domain SARAF PF06682.12 ETO14049.1 - 0.012 15.3 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Mid2 PF04478.12 ETO14049.1 - 0.045 13.6 7.6 0.084 12.7 7.6 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor DUF1676 PF07898.13 ETO14049.1 - 0.045 13.8 0.0 0.21 11.6 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DUF4711 PF15829.5 ETO14049.1 - 0.049 13.6 3.8 0.073 13.0 3.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) DUF4448 PF14610.6 ETO14049.1 - 0.077 12.8 0.1 0.11 12.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) EMP24_GP25L PF01105.24 ETO14049.1 - 0.17 11.8 1.9 0.2 11.6 1.9 1.4 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF3827 PF12877.7 ETO14049.1 - 2 6.7 10.2 2.9 6.2 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Sigma_reg_N PF13800.6 ETO14049.1 - 3.9 7.8 16.8 8.9 6.7 16.8 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Baculo_11_kDa PF06143.11 ETO14049.1 - 9 6.0 13.4 21 4.7 13.4 1.6 1 0 0 1 1 1 0 Baculovirus 11 kDa family ASFV_J13L PF05568.11 ETO14049.1 - 9.1 6.0 14.8 19 4.9 14.8 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein Bromodomain PF00439.25 ETO14050.1 - 0.00075 19.5 0.0 0.0027 17.8 0.0 2.0 1 0 0 1 1 1 1 Bromodomain NigD_N PF12667.7 ETO14050.1 - 0.12 12.5 0.5 0.35 11.0 0.5 1.8 1 0 0 1 1 1 0 NigD-like N-terminal OB domain PH PF00169.29 ETO14052.1 - 2.2e-08 34.6 0.3 2.2e-08 34.6 0.3 2.0 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO14052.1 - 0.00027 21.3 0.3 0.00027 21.3 0.3 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_16 PF17838.1 ETO14052.1 - 0.0039 17.0 0.6 0.0072 16.2 0.0 1.8 2 0 0 2 2 2 1 PH domain Mcp5_PH PF12814.7 ETO14052.1 - 0.038 14.1 0.1 0.038 14.1 0.1 2.7 2 1 1 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology MotB_plug PF13677.6 ETO14052.1 - 0.13 11.9 1.0 0.66 9.6 0.2 2.5 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB PH_6 PF15406.6 ETO14052.1 - 0.14 12.4 2.0 0.33 11.3 0.2 2.5 2 1 0 2 2 2 0 Pleckstrin homology domain PDCD2_C PF04194.13 ETO14053.1 - 2.1e-22 80.0 16.9 2e-20 73.6 10.8 3.3 2 1 0 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain PSCyt3 PF07627.11 ETO14053.1 - 0.01 16.1 0.5 0.044 14.1 0.5 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1588) PLATZ PF04640.14 ETO14053.1 - 0.32 11.6 4.2 2.4 8.8 1.5 2.9 2 0 0 2 2 2 0 PLATZ transcription factor zf-piccolo PF05715.13 ETO14053.1 - 0.83 9.9 7.9 0.48 10.6 2.7 2.7 3 0 0 3 3 3 0 Piccolo Zn-finger Dymeclin PF09742.9 ETO14054.1 - 4.3e-10 38.7 2.5 5.3e-10 38.4 2.5 1.1 1 0 0 1 1 1 1 Dyggve-Melchior-Clausen syndrome protein DUF4471 PF14740.6 ETO14054.1 - 0.021 14.1 1.3 0.18 11.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) FAM176 PF14851.6 ETO14054.1 - 0.064 12.9 3.5 0.11 12.2 3.5 1.3 1 0 0 1 1 1 0 FAM176 family RNA_pol_3_Rpc31 PF11705.8 ETO14054.1 - 0.072 13.3 8.2 0.11 12.7 8.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Myc_N PF01056.18 ETO14054.1 - 0.089 12.7 5.6 0.13 12.2 5.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Vpu PF00558.19 ETO14054.1 - 0.32 10.8 4.1 0.7 9.7 4.1 1.6 1 0 0 1 1 1 0 Vpu protein TRAP_alpha PF03896.16 ETO14054.1 - 0.37 10.0 2.4 0.52 9.5 2.4 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit UCMA PF17085.5 ETO14054.1 - 0.99 9.4 6.5 1.8 8.6 6.5 1.4 1 0 0 1 1 1 0 Unique cartilage matrix associated protein NOA36 PF06524.12 ETO14054.1 - 3.9 6.7 9.2 5.8 6.1 9.2 1.1 1 0 0 1 1 1 0 NOA36 protein GAS PF13851.6 ETO14055.1 - 0.0075 15.6 22.3 0.0075 15.6 22.3 5.1 1 1 3 5 5 5 1 Growth-arrest specific micro-tubule binding P_gingi_FimA PF06321.11 ETO14055.1 - 0.07 13.2 2.5 0.25 11.4 2.5 2.0 1 0 0 1 1 1 0 Major fimbrial subunit protein (FimA) CAML PF14963.6 ETO14057.1 - 1.3e-05 25.5 0.3 1.3e-05 25.5 0.3 1.9 1 1 1 2 2 2 1 Calcium signal-modulating cyclophilin ligand CLN3 PF02487.17 ETO14057.1 - 0.0031 16.6 1.9 0.0043 16.2 0.1 1.9 2 0 0 2 2 2 1 CLN3 protein DUF4820 PF16091.5 ETO14057.1 - 4.2 6.7 17.2 4 6.7 10.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) SAM_1 PF00536.30 ETO14059.1 - 2.9e-21 75.6 3.5 7.6e-12 45.5 0.3 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO14059.1 - 9.5e-19 67.3 2.3 3.9e-08 33.3 0.1 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Nup54_57_C PF18570.1 ETO14059.1 - 0.038 13.6 8.9 0.36 10.5 5.6 3.5 2 0 0 2 2 2 0 NUP57/Nup54 C-terminal domain RraB PF06877.11 ETO14059.1 - 1.8 9.3 12.0 0.11 13.2 4.4 2.9 3 0 0 3 3 3 0 Regulator of ribonuclease activity B SPRY PF00622.28 ETO14060.1 - 0.064 13.4 0.2 0.17 12.0 0.1 1.7 1 1 0 1 1 1 0 SPRY domain DUF5592 PF17332.2 ETO14061.1 - 0.15 12.6 1.7 0.26 11.9 0.0 2.1 2 1 0 2 2 2 0 Family of unknown function (DUF5592) UCH PF00443.29 ETO14061.1 - 2.1 7.8 7.3 2.6 7.5 7.3 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Tyrosinase PF00264.20 ETO14062.1 - 1.4 9.1 7.8 0.61 10.3 5.1 1.7 1 1 1 2 2 2 0 Common central domain of tyrosinase PBP1_TM PF14812.6 ETO14062.1 - 1.6 9.2 8.8 6.4 7.2 1.4 2.9 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ras PF00071.22 ETO14063.1 - 3.2e-09 36.6 0.7 5.9e-09 35.7 0.7 1.5 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 ETO14063.1 - 0.037 13.6 0.1 0.054 13.0 0.1 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain POC3_POC4 PF10448.9 ETO14063.1 - 0.14 12.1 3.6 2.2 8.3 1.0 2.3 1 1 1 2 2 2 0 20S proteasome chaperone assembly proteins 3 and 4 IMUP PF15761.5 ETO14063.1 - 0.27 11.9 1.7 0.48 11.1 1.7 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein MIF4G PF02854.19 ETO14065.1 - 2.5e-08 33.8 1.3 2.5e-08 33.8 1.3 2.7 4 0 0 4 4 4 1 MIF4G domain PspB PF06667.12 ETO14065.1 - 0.47 10.6 4.5 0.17 12.0 0.4 2.4 2 0 0 2 2 2 0 Phage shock protein B MHC_I PF00129.18 ETO14066.1 - 0.06 12.9 1.5 0.082 12.5 0.2 1.7 1 1 1 2 2 2 0 Class I Histocompatibility antigen, domains alpha 1 and 2 PPDFL PF15060.6 ETO14066.1 - 0.16 12.5 2.8 0.14 12.6 0.6 2.1 1 1 1 2 2 2 0 Differentiation and proliferation regulator Neur_chan_memb PF02932.16 ETO14066.1 - 0.37 10.8 6.7 0.5 10.4 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nrap_D5 PF17406.2 ETO14066.1 - 1.7 8.3 5.1 6.2 6.6 5.1 1.9 1 1 0 1 1 1 0 Nrap protein PAP/OAS1-like domain 5 DUF3537 PF12056.8 ETO14066.1 - 4.3 6.1 7.0 1.8 7.3 4.9 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3537) RNase_H2_suC PF08615.11 ETO14067.1 - 2.3e-07 31.1 0.1 3.2e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) C9orf72-like PF15019.6 ETO14068.1 - 4.1e-20 72.4 0.1 3.6e-19 69.3 0.0 2.2 2 0 0 2 2 2 1 C9orf72-like protein family Cnd2 PF05786.14 ETO14069.1 - 2.6e-47 162.0 6.8 4.1e-47 161.4 6.8 1.3 1 1 0 1 1 1 1 Condensin complex subunit 2 CNDH2_N PF06278.11 ETO14069.1 - 0.00015 22.0 1.5 0.00064 19.9 0.3 2.5 2 0 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal Rad21_Rec8_N PF04825.13 ETO14069.1 - 0.086 13.0 0.1 0.25 11.5 0.1 1.8 1 1 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein Cnd2 PF05786.14 ETO14070.1 - 2.2e-37 129.2 27.4 1.2e-36 126.7 27.4 1.9 1 1 0 1 1 1 1 Condensin complex subunit 2 AATF-Che1 PF13339.6 ETO14071.1 - 0.015 16.0 5.4 0.015 16.0 5.4 1.3 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor CENP-B_dimeris PF09026.10 ETO14071.1 - 0.034 14.5 3.8 0.21 12.0 4.3 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF382 PF04037.13 ETO14071.1 - 0.17 12.0 3.0 1 9.6 0.3 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF382) DUF1043 PF06295.12 ETO14071.1 - 0.18 11.8 4.7 0.17 11.9 3.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) zf-C3HC4_3 PF13920.6 ETO14072.1 - 9.4e-07 28.6 12.5 2.4e-06 27.3 12.5 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO14072.1 - 2.6e-05 24.0 10.1 7.1e-05 22.6 10.1 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO14072.1 - 0.018 15.4 11.3 0.018 15.4 11.3 3.0 2 0 0 2 2 2 0 Ring finger domain Keratin_2_head PF16208.5 ETO14072.1 - 0.18 11.9 6.8 0.38 10.9 6.8 1.4 1 0 0 1 1 1 0 Keratin type II head zf-C3HC4 PF00097.25 ETO14072.1 - 0.24 11.3 12.8 0.83 9.6 12.8 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO14072.1 - 0.31 11.0 15.0 1.1 9.3 15.0 2.1 1 0 0 1 1 1 0 zinc-RING finger domain KRTAP PF11759.8 ETO14072.1 - 1.7 9.2 6.9 3.6 8.2 6.9 1.4 1 0 0 1 1 1 0 Keratin-associated matrix BRCT PF00533.26 ETO14074.1 - 0.0088 16.4 2.0 3.2 8.2 0.5 2.7 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 ETO14074.1 - 0.21 11.5 2.5 0.31 10.9 0.0 2.2 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain DUF4492 PF14899.6 ETO14075.1 - 0.021 14.8 0.3 0.021 14.8 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4492) O-antigen_lig PF13425.6 ETO14075.1 - 0.37 9.5 1.3 0.5 9.1 1.3 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Conotoxin PF02950.17 ETO14075.1 - 0.57 11.2 1.9 3.6 8.7 0.0 2.4 2 1 0 2 2 2 0 Conotoxin OATP PF03137.20 ETO14075.1 - 2.2 6.5 3.9 3.7 5.7 3.8 1.6 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family EF-hand_1 PF00036.32 ETO14077.1 - 1.2e-16 58.9 8.2 0.00012 21.4 0.3 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO14077.1 - 1.6e-13 49.4 6.2 0.00066 19.4 0.8 4.9 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ETO14077.1 - 3e-13 50.0 10.3 1.6e-06 28.5 1.0 3.7 3 2 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO14077.1 - 1.9e-07 30.8 4.2 6.3e-05 22.7 0.1 3.7 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO14077.1 - 0.00024 20.4 9.9 0.001 18.5 0.2 4.3 4 0 0 4 4 4 1 EF hand FAM76 PF16046.5 ETO14077.1 - 0.00063 19.2 3.4 0.00063 19.2 3.4 3.0 3 0 0 3 3 3 1 FAM76 protein SPARC_Ca_bdg PF10591.9 ETO14077.1 - 0.0046 17.3 14.1 0.039 14.3 0.2 3.8 4 0 0 4 4 4 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO14077.1 - 0.0053 16.7 5.9 1.5 8.8 0.1 3.7 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand Spc7 PF08317.11 ETO14077.1 - 0.084 11.7 44.4 0.016 14.1 13.5 3.4 3 1 0 3 3 3 0 Spc7 kinetochore protein EF-hand_9 PF14658.6 ETO14077.1 - 0.13 12.6 0.5 21 5.6 0.0 4.0 4 0 0 4 4 4 0 EF-hand domain Sulfatase_C PF14707.6 ETO14077.1 - 0.76 10.5 6.2 0.56 11.0 0.6 3.2 3 0 0 3 3 3 0 C-terminal region of aryl-sulfatase DegQ PF08181.11 ETO14077.1 - 1.1 9.4 10.0 0.74 10.0 0.4 4.1 3 1 0 3 3 3 0 DegQ (SacQ) family BLOC1_2 PF10046.9 ETO14077.1 - 4.6 7.6 24.3 1.2 9.5 2.2 3.9 3 2 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4709 PF15821.5 ETO14078.1 - 8.5 6.7 23.6 4.8 7.5 7.6 3.5 2 1 0 3 3 3 0 Domain of unknown function (DUF4709) DUF3439 PF11921.8 ETO14079.1 - 0.71 9.9 13.5 2.9 7.9 13.5 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Methyltransf_12 PF08242.12 ETO14079.1 - 1.3 9.8 8.2 5.6 7.8 1.6 2.9 2 0 0 2 2 2 0 Methyltransferase domain Ubiq_cyt_C_chap PF03981.12 ETO14080.1 - 3e-06 27.4 0.8 0.054 13.6 0.3 2.2 2 0 0 2 2 2 2 Ubiquinol-cytochrome C chaperone DUF5101 PF17031.5 ETO14080.1 - 0.099 12.7 2.0 0.27 11.4 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5101) DUF4120 PF13496.6 ETO14082.1 - 0.016 15.5 1.9 0.026 14.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4120) ATP-synt_B PF00430.18 ETO14082.1 - 0.017 15.2 6.3 0.035 14.2 6.3 1.5 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) CspB_prodomain PF18425.1 ETO14082.1 - 0.08 12.9 2.6 4.7 7.3 0.1 2.7 2 1 0 2 2 2 0 Csp protease B prodomain UBX PF00789.20 ETO14083.1 - 1.3e-09 38.1 0.0 2.8e-09 37.1 0.0 1.6 1 0 0 1 1 1 1 UBX domain Pyridoxal_deC PF00282.19 ETO14086.1 - 5.6e-07 28.6 0.1 4.7e-06 25.6 0.0 2.0 2 0 0 2 2 2 1 Pyridoxal-dependent decarboxylase conserved domain Beta_elim_lyase PF01212.21 ETO14086.1 - 0.0033 16.7 0.0 0.0051 16.1 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Hpr_kinase_N PF02603.16 ETO14086.1 - 0.054 13.5 0.0 0.14 12.2 0.0 1.7 2 0 0 2 2 2 0 HPr Serine kinase N terminus PUB PF09409.10 ETO14087.1 - 0.00018 21.3 0.0 0.00047 20.0 0.0 1.6 1 0 0 1 1 1 1 PUB domain ZnuA PF01297.17 ETO14087.1 - 0.11 11.9 0.3 1 8.7 0.1 1.9 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic CE2_N PF17996.1 ETO14087.1 - 0.12 12.3 0.1 0.23 11.5 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal CAP_GLY PF01302.25 ETO14089.1 - 1.8e-11 43.9 0.1 4.1e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain SPRR2 PF14820.6 ETO14089.1 - 1.7 8.8 14.0 9.4 6.4 0.1 4.5 3 1 2 5 5 5 0 Small proline-rich 2 Guanylate_cyc PF00211.20 ETO14090.1 - 1.3e-07 31.4 0.0 3e-07 30.3 0.0 1.6 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 ETO14090.1 - 4.8e-06 27.0 0.0 7.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain F420_oxidored PF03807.17 ETO14091.1 - 4.5e-12 46.4 0.1 4.3e-07 30.4 0.2 2.3 2 0 0 2 2 2 2 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ETO14091.1 - 4.8e-10 39.8 0.0 9.2e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ETO14091.1 - 0.00021 21.2 0.6 0.00045 20.2 0.6 1.6 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Shikimate_DH PF01488.20 ETO14091.1 - 0.00089 19.3 0.2 0.085 12.9 0.1 2.1 2 0 0 2 2 2 1 Shikimate / quinate 5-dehydrogenase 2-Hacid_dh_C PF02826.19 ETO14091.1 - 0.0013 18.1 0.0 0.01 15.2 0.0 2.0 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NmrA PF05368.13 ETO14091.1 - 0.011 15.3 0.1 0.024 14.2 0.1 1.6 1 1 0 1 1 1 0 NmrA-like family adh_short PF00106.25 ETO14091.1 - 0.014 14.8 0.0 0.033 13.7 0.0 1.5 1 0 0 1 1 1 0 short chain dehydrogenase NAD_Gly3P_dh_N PF01210.23 ETO14091.1 - 0.017 15.1 0.2 0.28 11.2 0.0 2.5 3 0 0 3 3 3 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus DFP PF04127.15 ETO14091.1 - 0.069 13.0 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein WD40 PF00400.32 ETO14092.1 - 4.5e-63 207.7 21.5 9.3e-10 39.0 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14092.1 - 3.6e-25 88.1 4.1 0.00029 21.1 0.0 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14092.1 - 1.7e-19 70.0 2.7 0.0087 15.1 0.2 6.4 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO14092.1 - 2.4e-13 50.4 0.2 1.8e-06 28.0 0.0 3.2 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO14092.1 - 1.3e-07 31.3 9.7 6.2 6.9 0.2 6.9 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO14092.1 - 1.9e-07 30.1 3.8 0.73 8.4 0.1 4.8 1 1 3 5 5 5 4 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO14092.1 - 9.2e-06 24.6 0.1 0.028 13.2 0.0 4.2 1 1 3 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nbas_N PF15492.6 ETO14092.1 - 1.3e-05 24.7 2.7 0.19 11.0 0.0 4.5 2 1 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ETO14092.1 - 3.5e-05 23.3 0.5 1.6 8.0 0.0 3.8 1 1 3 4 4 4 2 WD40-like domain Str_synth PF03088.16 ETO14092.1 - 0.00014 21.9 0.7 10 6.3 0.0 5.4 4 3 3 7 7 7 1 Strictosidine synthase GSDH PF07995.11 ETO14092.1 - 0.00046 19.6 0.0 0.075 12.3 0.0 3.2 2 1 1 3 3 3 1 Glucose / Sorbosone dehydrogenase Cytochrom_D1 PF02239.16 ETO14092.1 - 0.00063 18.4 3.9 0.6 8.6 0.4 3.5 1 1 0 2 2 2 2 Cytochrome D1 heme domain NHL PF01436.21 ETO14092.1 - 0.092 12.8 0.5 0.7 10.0 0.1 2.5 2 0 0 2 2 2 0 NHL repeat Proteasome_A_N PF10584.9 ETO14092.1 - 0.59 9.9 11.4 73 3.2 0.0 6.1 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO14093.1 - 3.3e-58 192.3 16.6 1.4e-09 38.4 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14093.1 - 3.9e-28 97.6 3.2 0.00094 19.4 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14093.1 - 3e-13 49.5 2.4 0.018 14.0 0.0 5.3 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14093.1 - 2.7e-10 40.1 6.0 2.7e-05 23.7 0.6 3.6 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO14093.1 - 1.1e-07 30.9 12.3 0.51 8.9 0.0 6.0 1 1 5 6 6 6 5 Nucleoporin Nup120/160 PQQ PF01011.21 ETO14093.1 - 7e-05 22.6 0.2 4.6 7.4 0.0 4.7 5 0 0 5 5 5 1 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETO14093.1 - 8.5e-05 21.2 0.8 0.41 9.1 0.2 3.3 1 1 3 4 4 4 4 Cytochrome D1 heme domain PD40 PF07676.12 ETO14093.1 - 0.00025 20.9 3.0 0.31 11.0 0.1 4.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO14093.1 - 0.0056 16.1 4.5 6.6 6.0 0.0 4.1 1 1 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO14093.1 - 0.17 10.9 4.4 0.49 9.4 1.8 2.2 1 1 2 3 3 3 0 Coatomer WD associated region Guanylate_cyc PF00211.20 ETO14094.1 - 5.1e-11 42.5 0.3 1.3e-10 41.2 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain GGDEF_2 PF17853.1 ETO14094.1 - 0.2 11.9 0.0 0.45 10.8 0.0 1.6 1 1 0 1 1 1 0 GGDEF-like domain Lenti_VIF_2 PF07401.12 ETO14095.1 - 0.11 11.8 0.0 0.2 11.0 0.0 1.4 1 0 0 1 1 1 0 Bovine Lentivirus VIF protein EF-hand_7 PF13499.6 ETO14096.1 - 6.7e-06 26.5 1.4 0.07 13.6 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO14096.1 - 2.7e-05 23.9 1.6 0.017 14.9 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO14096.1 - 0.00078 19.2 1.4 0.73 9.9 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain SSP160 PF06933.11 ETO14096.1 - 0.0019 16.5 0.7 0.0021 16.4 0.7 1.2 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 EF-hand_1 PF00036.32 ETO14096.1 - 0.0022 17.4 6.3 0.16 11.6 0.2 3.8 4 0 0 4 4 4 2 EF hand RRM_1 PF00076.22 ETO14097.1 - 7.2e-07 28.9 0.1 5.1e-06 26.2 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pex16 PF08610.10 ETO14098.1 - 1.2e-15 57.5 0.0 3.2e-15 56.1 0.0 1.5 1 1 0 1 1 1 1 Peroxisomal membrane protein (Pex16) Pkinase PF00069.25 ETO14100.1 - 3.8e-36 124.8 0.1 5.9e-36 124.2 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 ETO14100.1 - 9.1e-17 60.9 0.0 1.1e-12 47.9 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 ETO14100.1 - 2.8e-16 59.6 0.1 4.5e-16 58.9 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO14100.1 - 0.0078 15.2 0.2 0.012 14.5 0.2 1.2 1 0 0 1 1 1 1 Haspin like kinase domain PhyH PF05721.13 ETO14101.1 - 8.1e-05 23.0 0.0 0.016 15.5 0.0 2.8 3 0 0 3 3 3 2 Phytanoyl-CoA dioxygenase (PhyH) DUF599 PF04654.12 ETO14102.1 - 0.16 11.4 0.1 0.79 9.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF599 Sugar_tr PF00083.24 ETO14102.1 - 1 8.2 3.2 2 7.2 3.2 1.4 1 0 0 1 1 1 0 Sugar (and other) transporter Mito_carr PF00153.27 ETO14103.1 - 1.4e-56 188.4 5.7 2.2e-19 69.2 0.4 4.2 3 1 0 3 3 3 3 Mitochondrial carrier protein Phage_holin_5_2 PF16079.5 ETO14103.1 - 0.041 14.2 0.6 0.12 12.7 0.1 2.1 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V DUF630 PF04783.12 ETO14103.1 - 0.071 13.3 0.3 0.14 12.3 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF630) Glyco_hydro_47 PF01532.20 ETO14104.1 - 1.4e-63 215.4 0.0 1.5e-63 215.3 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Pkinase PF00069.25 ETO14105.1 - 3.5e-16 59.3 0.1 3.1e-15 56.3 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14105.1 - 0.0008 18.8 0.0 0.0015 17.9 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ETO14105.1 - 0.018 14.6 0.0 0.044 13.4 0.0 1.6 1 0 0 1 1 1 0 Choline/ethanolamine kinase WD40 PF00400.32 ETO14106.1 - 1.2e-125 405.7 55.8 5.5e-09 36.5 1.6 15.6 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14106.1 - 2.9e-25 88.4 13.8 0.11 12.9 0.0 12.1 2 2 12 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14106.1 - 3.8e-24 85.3 14.4 0.4 9.6 0.0 14.2 1 1 14 15 15 15 9 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14106.1 - 4.3e-15 55.8 7.3 0.0083 15.5 0.0 7.7 5 3 3 8 8 8 5 WD40-like domain NACHT PF05729.12 ETO14106.1 - 9.5e-09 35.4 0.0 2.1e-08 34.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain DUF5570 PF17731.1 ETO14106.1 - 0.00034 20.7 24.7 3.5 7.7 0.7 8.4 2 2 6 9 9 9 2 Family of unknown function (DUF5570) PD40 PF07676.12 ETO14106.1 - 0.00087 19.2 22.0 5 7.2 0.0 9.8 11 0 0 11 11 11 2 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO14106.1 - 0.0015 18.1 3.0 0.0041 16.7 3.0 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO14106.1 - 0.018 15.2 0.3 0.049 13.8 0.3 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO14106.1 - 0.036 14.3 0.0 0.17 12.2 0.0 2.2 1 0 0 1 1 1 0 AAA domain Read-through PF16814.5 ETO14106.1 - 3.4 7.4 5.6 9.8 5.9 0.2 4.2 4 1 0 4 4 4 0 Read-through domain Peptidase_C1 PF00112.23 ETO14107.1 - 8.9e-38 130.6 0.5 1.6e-37 129.8 0.5 1.4 1 1 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ETO14107.1 - 0.042 12.6 1.0 0.075 11.8 1.0 1.3 1 0 0 1 1 1 0 Peptidase C1-like family DUF4286 PF14114.6 ETO14108.1 - 0.39 11.2 3.3 0.38 11.3 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4286) TPR_1 PF00515.28 ETO14110.1 - 6.6e-20 70.0 23.4 0.0057 16.4 0.4 7.9 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14110.1 - 4.9e-18 63.8 16.2 0.0015 18.6 0.3 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14110.1 - 3.2e-15 54.9 27.1 0.044 13.9 0.0 8.5 10 0 0 10 10 9 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14110.1 - 1.7e-13 50.0 16.1 0.0047 16.6 0.1 7.4 7 1 1 8 8 8 4 TPR repeat TPR_12 PF13424.6 ETO14110.1 - 3.4e-13 49.7 20.5 0.00029 21.1 0.6 6.2 3 2 3 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETO14110.1 - 5e-13 49.4 8.8 1.8e-05 25.2 0.0 5.4 5 1 1 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO14110.1 - 1.2e-10 41.3 3.9 0.14 13.0 0.1 6.1 5 2 1 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14110.1 - 3e-10 39.8 16.7 0.1 13.0 0.1 8.2 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETO14110.1 - 1.9e-08 34.3 2.1 0.024 14.8 0.0 4.5 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14110.1 - 4.8e-08 33.5 1.2 0.89 10.3 0.0 4.9 4 2 2 6 6 5 2 Tetratricopeptide repeat SAM_2 PF07647.17 ETO14110.1 - 1.7e-07 31.2 0.1 3.8e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_6 PF13174.6 ETO14110.1 - 9e-06 26.0 10.9 0.44 11.3 0.0 6.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO14110.1 - 0.00027 20.4 1.1 0.69 9.2 0.0 3.7 3 1 0 3 3 3 2 MalT-like TPR region SHNi-TPR PF10516.9 ETO14110.1 - 0.00039 19.8 0.2 0.19 11.2 0.0 3.2 3 0 0 3 3 3 1 SHNi-TPR Fis1_TPR_C PF14853.6 ETO14110.1 - 0.0032 17.5 0.9 15 5.8 0.2 4.3 3 1 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 ETO14110.1 - 0.031 14.2 16.4 1.2 9.1 0.1 6.5 7 0 0 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14110.1 - 0.036 14.3 21.5 0.89 9.8 0.1 5.5 5 2 1 6 6 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETO14110.1 - 0.097 13.0 0.0 0.82 10.0 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ETO14110.1 - 0.1 12.3 0.1 11 5.7 0.0 2.5 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_7 PF13176.6 ETO14110.1 - 0.36 11.0 11.8 23 5.3 0.0 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat Pribosyltran PF00156.27 ETO14112.1 - 1.9e-18 66.5 0.0 3e-18 65.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ETO14112.1 - 0.0032 17.0 0.1 0.0051 16.3 0.1 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ETO14112.1 - 0.031 13.8 0.0 0.048 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase 3Beta_HSD PF01073.19 ETO14114.1 - 3.9e-29 101.5 0.0 4.3e-29 101.4 0.0 1.0 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO14114.1 - 1.7e-09 37.5 0.0 2.1e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family MMR_HSR1_Xtn PF16897.5 ETO14115.1 - 4.1e-37 126.4 1.1 9.5e-37 125.3 1.1 1.6 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TGS PF02824.21 ETO14115.1 - 3.8e-22 78.1 0.1 8.2e-22 77.0 0.1 1.6 1 0 0 1 1 1 1 TGS domain MMR_HSR1 PF01926.23 ETO14115.1 - 7.2e-20 71.2 0.0 1.6e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO14115.1 - 3.5e-10 39.6 0.2 2.7e-09 36.7 0.0 2.3 3 0 0 3 3 3 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ETO14115.1 - 0.0028 17.7 0.0 2.4 8.2 0.0 2.5 2 0 0 2 2 2 2 Dynamin family MeaB PF03308.16 ETO14115.1 - 0.0076 15.3 0.1 0.015 14.3 0.1 1.4 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB GTP_EFTU PF00009.27 ETO14115.1 - 0.03 13.9 0.1 0.56 9.7 0.0 2.5 1 1 1 2 2 2 0 Elongation factor Tu GTP binding domain ABC_tran PF00005.27 ETO14115.1 - 0.13 12.7 0.0 0.79 10.2 0.0 2.1 2 1 0 2 2 2 0 ABC transporter Thg1 PF04446.12 ETO14116.1 - 3.1e-25 88.6 0.0 4e-24 85.0 0.0 2.3 1 1 0 1 1 1 1 tRNAHis guanylyltransferase bZIP_1 PF00170.21 ETO14116.1 - 0.0066 16.5 0.9 0.096 12.8 0.1 2.5 2 0 0 2 2 2 1 bZIP transcription factor Cys_box PF17869.1 ETO14116.1 - 0.028 14.5 2.2 0.059 13.5 0.3 2.4 2 0 0 2 2 2 0 Anosmin cysteine rich domain TipAS PF07739.13 ETO14116.1 - 0.028 14.9 0.5 0.51 10.9 0.1 2.5 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain Vac_Fusion PF02346.16 ETO14116.1 - 0.035 13.7 0.6 0.25 11.0 0.0 2.6 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DUF3463 PF11946.8 ETO14116.1 - 0.085 12.7 0.7 0.17 11.7 0.2 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3463) CLZ PF16526.5 ETO14116.1 - 0.22 11.9 2.3 0.28 11.6 0.3 2.2 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tnp_22_trimer PF17489.2 ETO14120.1 - 0.17 11.8 2.0 0.33 11.0 2.0 1.4 1 0 0 1 1 1 0 L1 transposable element trimerization domain LRR_6 PF13516.6 ETO14121.1 - 7.8e-08 31.8 22.8 0.0062 16.5 0.2 5.8 6 0 0 6 6 6 5 Leucine Rich repeat Rav1p_C PF12234.8 ETO14122.1 - 2.9e-28 98.7 13.0 7.9e-28 97.3 13.0 1.7 1 0 0 1 1 1 1 RAVE protein 1 C terminal SR-25 PF10500.9 ETO14122.1 - 0.0034 17.0 10.0 0.0034 17.0 10.0 4.8 4 1 1 5 5 5 2 Nuclear RNA-splicing-associated protein ICL PF00463.21 ETO14122.1 - 0.0089 14.6 0.6 0.015 13.8 0.6 1.2 1 0 0 1 1 1 1 Isocitrate lyase family SAM_1 PF00536.30 ETO14123.1 - 1e-07 32.2 0.2 2.3e-07 31.2 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO14123.1 - 2.7e-05 24.2 0.1 6e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO14123.1 - 0.00091 19.1 0.0 0.002 18.1 0.0 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DUF4764 PF15961.5 ETO14126.1 - 0.26 10.0 14.9 0.013 14.2 0.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4764) Barttin PF15462.6 ETO14126.1 - 0.58 9.9 6.0 0.28 10.9 0.1 2.5 2 0 0 2 2 2 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Chordopox_G3 PF06129.12 ETO14126.1 - 1.2 9.8 5.5 0.51 11.1 0.2 2.4 2 0 0 2 2 2 0 Chordopoxvirus G3 protein THRAP3_BCLAF1 PF15440.6 ETO14126.1 - 2.5 7.0 27.4 20 4.0 27.2 2.0 1 1 0 1 1 1 0 THRAP3/BCLAF1 family SGL PF08450.12 ETO14128.1 - 5.9e-06 26.1 0.1 0.015 14.9 0.0 2.9 1 1 2 3 3 3 3 SMP-30/Gluconolactonase/LRE-like region Arylesterase PF01731.20 ETO14128.1 - 1.7e-05 24.9 0.0 0.1 12.8 0.0 4.0 3 1 1 4 4 4 2 Arylesterase Lactonase PF10282.9 ETO14128.1 - 3.4e-05 23.3 0.4 0.0032 16.8 0.2 2.3 1 1 1 2 2 2 2 Lactonase, 7-bladed beta-propeller DEK_C PF08766.11 ETO14129.1 - 9.2e-13 47.9 0.2 1.4e-12 47.3 0.2 1.3 1 0 0 1 1 1 1 DEK C terminal domain PC4 PF02229.16 ETO14129.1 - 0.00013 21.5 0.1 0.0011 18.6 0.0 2.3 2 0 0 2 2 2 1 Transcriptional Coactivator p15 (PC4) Presenilin PF01080.17 ETO14129.1 - 6.2 5.5 10.8 7 5.3 10.8 1.2 1 0 0 1 1 1 0 Presenilin Acetyltransf_13 PF13880.6 ETO14130.1 - 1.5e-26 92.2 0.1 2.5e-26 91.5 0.1 1.4 1 0 0 1 1 1 1 ESCO1/2 acetyl-transferase Acetyltransf_7 PF13508.7 ETO14130.1 - 0.0019 18.6 0.2 0.0082 16.6 0.2 2.1 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO14130.1 - 0.0082 16.4 0.5 0.019 15.2 0.5 1.7 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Neur_chan_memb PF02932.16 ETO14130.1 - 1.4 9.0 11.2 0.4 10.7 8.1 1.6 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region TPR_12 PF13424.6 ETO14131.1 - 1.8e-25 89.0 0.5 3.3e-08 33.7 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14131.1 - 3.1e-21 74.2 15.7 2.1e-06 27.3 0.4 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14131.1 - 2.1e-17 61.8 3.0 0.00014 21.6 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14131.1 - 8.7e-16 57.2 0.1 0.0013 18.5 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14131.1 - 4.4e-14 51.4 15.1 1.6e-05 24.7 0.1 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14131.1 - 2.9e-12 45.8 20.0 0.0017 18.4 0.2 5.0 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO14131.1 - 5.3e-05 23.6 2.2 0.14 12.8 0.2 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14131.1 - 9.8e-05 22.5 0.4 11 6.7 0.1 4.4 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14131.1 - 0.0008 20.0 0.0 2 9.2 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO14131.1 - 0.0008 20.0 0.0 0.23 12.4 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO14131.1 - 0.0015 17.9 0.2 0.0075 15.7 0.0 2.3 3 0 0 3 3 3 1 SHNi-TPR TPR_MalT PF17874.1 ETO14131.1 - 0.013 14.9 0.1 2.6 7.3 0.0 2.2 2 0 0 2 2 2 0 MalT-like TPR region TPR_11 PF13414.6 ETO14131.1 - 0.015 15.0 12.0 0.36 10.6 0.1 5.0 4 1 1 5 5 5 0 TPR repeat Fis1_TPR_C PF14853.6 ETO14131.1 - 0.021 14.9 4.0 0.59 10.2 0.5 2.7 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ETO14131.1 - 0.043 14.0 9.7 1.3 9.3 0.5 3.9 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO14131.1 - 0.11 12.3 6.6 1.8 8.3 2.2 3.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO14131.1 - 0.14 12.7 0.1 6.5 7.3 0.0 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETO14131.1 - 0.17 12.0 8.0 1.8 8.7 0.0 3.6 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO14131.1 - 1 9.7 7.4 25 5.4 0.0 5.1 5 1 1 6 6 5 0 PPR repeat VMA21 PF09446.10 ETO14132.1 - 0.022 14.8 0.8 0.022 14.8 0.8 1.8 2 0 0 2 2 2 0 VMA21-like domain zf-TRAF PF02176.18 ETO14133.1 - 9.8e-06 26.2 1.8 9.8e-06 26.2 1.8 2.8 3 0 0 3 3 3 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETO14133.1 - 0.11 12.4 4.1 0.66 9.9 4.1 2.4 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Exonuc_VII_L PF02601.15 ETO14133.1 - 0.18 11.3 2.0 0.27 10.7 2.0 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tyr_Deacylase PF02580.16 ETO14134.1 - 1.2e-15 58.3 0.2 1.1e-14 55.2 0.2 2.1 1 1 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase RE_ScaI PF09569.10 ETO14134.1 - 0.094 12.4 0.1 0.13 12.0 0.1 1.2 1 0 0 1 1 1 0 ScaI restriction endonuclease adh_short PF00106.25 ETO14135.1 - 8.9e-29 100.3 0.0 2.4e-28 99.0 0.0 1.7 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO14135.1 - 1.5e-10 41.0 0.0 2.6e-10 40.2 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO14135.1 - 8.1e-09 35.6 0.1 1.3e-08 34.9 0.1 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO14135.1 - 4.2e-05 22.8 0.2 0.00013 21.2 0.0 1.7 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein VWA PF00092.28 ETO14135.1 - 0.078 13.2 0.0 0.19 12.0 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain Copine PF07002.16 ETO14135.1 - 0.085 12.3 0.0 0.15 11.5 0.0 1.4 1 0 0 1 1 1 0 Copine NPR3 PF03666.13 ETO14136.1 - 0.048 12.5 9.5 0.01 14.7 6.6 1.4 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO14136.1 - 0.28 10.4 2.0 0.33 10.1 2.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RPN2_C PF18004.1 ETO14136.1 - 5.6 6.9 18.1 9.3 6.1 18.1 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ETO14136.1 - 8.1 5.1 8.9 11 4.7 8.9 1.1 1 0 0 1 1 1 0 Presenilin ENTH PF01417.20 ETO14137.1 - 3.7e-09 36.7 0.8 4.9e-09 36.3 0.8 1.2 1 0 0 1 1 1 1 ENTH domain CAP PF00188.26 ETO14137.1 - 0.018 15.9 1.0 0.85 10.5 0.5 2.5 1 1 2 3 3 3 0 Cysteine-rich secretory protein family Sod_Ni PF09055.11 ETO14137.1 - 0.057 14.0 1.7 0.086 13.4 1.7 1.2 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase RecQ_Zn_bind PF16124.5 ETO14139.1 - 0.00021 22.0 6.2 0.00076 20.2 6.2 2.1 1 0 0 1 1 1 1 RecQ zinc-binding DUF809 PF05663.11 ETO14139.1 - 0.0069 16.5 0.6 0.13 12.4 1.0 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF809) Iwr1 PF08574.10 ETO14139.1 - 1.4 10.0 21.7 0.38 11.8 4.0 3.3 2 1 1 3 3 3 0 Transcription factor Iwr1 DEAD PF00270.29 ETO14141.1 - 1.2e-22 80.5 0.0 3.5e-22 79.0 0.0 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO14141.1 - 9.7e-09 35.6 0.1 3.2e-08 33.9 0.1 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Auts2 PF15336.6 ETO14141.1 - 0.45 10.6 11.2 0.24 11.5 8.8 1.7 1 1 0 1 1 1 0 Autism susceptibility gene 2 protein AAA_23 PF13476.6 ETO14141.1 - 0.91 10.0 12.0 20 5.6 11.4 2.7 2 0 0 2 2 2 0 AAA domain RR_TM4-6 PF06459.12 ETO14141.1 - 2.6 7.8 12.5 4.8 6.9 12.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Atrophin-1 PF03154.15 ETO14141.1 - 2.7 6.2 8.5 4.4 5.5 8.5 1.2 1 0 0 1 1 1 0 Atrophin-1 family TMEM214 PF10151.9 ETO14141.1 - 2.8 6.3 13.4 5.2 5.4 13.4 1.3 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator FAM176 PF14851.6 ETO14141.1 - 3.1 7.5 6.1 37 4.0 5.9 2.5 2 0 0 2 2 2 0 FAM176 family ALMT PF11744.8 ETO14141.1 - 3.6 6.3 7.4 6.6 5.4 7.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RP-C_C PF11800.8 ETO14141.1 - 6.2 6.9 7.3 0.79 9.8 2.8 1.7 2 0 0 2 2 1 0 Replication protein C C-terminal region O-antigen_lig PF13425.6 ETO14141.1 - 7.2 5.3 6.1 15 4.2 6.1 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Hydin_ADK PF17213.3 ETO14141.1 - 10 6.4 7.8 20 5.4 7.8 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PH_17 PF18012.1 ETO14144.1 - 0.0036 17.0 0.0 0.007 16.1 0.0 1.5 1 0 0 1 1 1 1 PH domain MRP_L53 PF10780.9 ETO14144.1 - 0.18 12.0 0.4 0.38 11.0 0.4 1.4 1 0 0 1 1 1 0 39S ribosomal protein L53/MRP-L53 Sulfatase PF00884.23 ETO14145.1 - 1.6e-33 116.4 2.8 2e-33 116.1 2.8 1.0 1 0 0 1 1 1 1 Sulfatase LUC7 PF03194.15 ETO14145.1 - 0.063 12.9 0.0 0.094 12.4 0.0 1.1 1 0 0 1 1 1 0 LUC7 N_terminus WD40 PF00400.32 ETO14146.1 - 1.9e-45 151.9 26.1 2e-07 31.6 0.2 7.4 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14146.1 - 8.8e-16 58.0 0.5 0.0015 18.8 0.0 5.9 5 1 0 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14146.1 - 4.1e-15 55.4 8.2 0.0095 14.6 0.2 6.0 2 2 4 6 6 6 6 Nucleoporin Nup120/160 Staphostatin_B PF09023.10 ETO14146.1 - 1.7 8.7 5.8 4.4 7.4 0.1 3.6 4 0 0 4 4 4 0 Staphostatin B RPM2 PF08579.11 ETO14147.1 - 0.0044 17.4 2.9 0.0044 17.4 2.9 2.1 2 1 0 2 2 2 1 Mitochondrial ribonuclease P subunit (RPM2) CT_C_D PF02682.16 ETO14147.1 - 0.088 12.5 0.1 0.17 11.6 0.1 1.4 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D SlyX PF04102.12 ETO14147.1 - 0.15 12.7 3.4 0.22 12.2 1.0 2.4 2 0 0 2 2 2 0 SlyX Cys_knot PF00007.22 ETO14147.1 - 1.7 9.0 12.6 0.34 11.2 6.9 2.2 1 1 0 2 2 2 0 Cystine-knot domain EF-hand_1 PF00036.32 ETO14148.1 - 0.0017 17.8 0.0 0.0036 16.7 0.0 1.6 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO14148.1 - 0.0058 16.5 0.1 0.015 15.2 0.1 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETO14148.1 - 0.096 13.1 0.9 0.23 11.9 0.1 2.2 2 0 0 2 2 2 0 EF-hand domain pair DUF4297 PF14130.6 ETO14149.1 - 0.044 13.9 0.0 0.066 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4297) Cullin_binding PF03556.15 ETO14151.1 - 2.2e-26 92.6 5.7 2.2e-26 92.6 5.7 1.9 2 0 0 2 2 2 1 Cullin binding UBA_4 PF14555.6 ETO14151.1 - 2.7e-10 39.9 0.1 5.4e-10 38.9 0.1 1.5 1 0 0 1 1 1 1 UBA-like domain TAP_C PF03943.13 ETO14151.1 - 0.0015 18.1 0.1 0.0038 16.8 0.1 1.6 1 0 0 1 1 1 1 TAP C-terminal domain CRAL_TRIO_N PF03765.15 ETO14151.1 - 0.0079 16.4 0.9 0.37 11.0 0.0 2.8 2 0 0 2 2 2 1 CRAL/TRIO, N-terminal domain DUF2279 PF10043.9 ETO14151.1 - 0.028 15.2 0.1 0.16 12.8 0.0 2.2 3 0 0 3 3 3 0 Predicted periplasmic lipoprotein (DUF2279) 30K_MP_core PF17644.1 ETO14151.1 - 0.084 12.7 0.0 0.21 11.5 0.0 1.6 1 0 0 1 1 1 0 Core domain of 30K viral movement proteins FIVAR PF07554.13 ETO14152.1 - 0.034 14.9 0.4 0.063 14.0 0.4 1.4 1 0 0 1 1 1 0 FIVAR domain SapC PF07277.11 ETO14153.1 - 0.0024 17.5 0.5 0.0045 16.6 0.5 1.4 1 0 0 1 1 1 1 SapC Helicase_C PF00271.31 ETO14154.1 - 6.2e-30 103.8 0.9 1.1e-29 103.1 0.1 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pullulanase_Ins PF18494.1 ETO14154.1 - 0.044 14.2 0.3 0.12 12.8 0.0 1.8 2 0 0 2 2 2 0 Pullulanase Ins domain Fanconi_A PF03511.14 ETO14154.1 - 0.044 13.7 0.0 0.096 12.6 0.0 1.5 1 0 0 1 1 1 0 Fanconi anaemia group A protein Apt1 PF10351.9 ETO14155.1 - 0.084 11.7 4.2 0.1 11.5 4.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ETO14155.1 - 2.7 6.4 6.5 3.4 6.1 6.5 1.0 1 0 0 1 1 1 0 Macoilin family SPRY PF00622.28 ETO14156.1 - 0.00046 20.3 0.0 0.00072 19.7 0.0 1.5 1 0 0 1 1 1 1 SPRY domain DUF2721 PF11026.8 ETO14157.1 - 0.014 15.2 3.2 3.6 7.5 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) Secretin_N_2 PF07655.13 ETO14157.1 - 1.2 9.8 20.0 0.22 12.1 9.6 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3784 PF12650.7 ETO14157.1 - 1.6 9.0 5.3 1.9 8.7 1.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) WD40 PF00400.32 ETO14158.1 - 4.6e-38 128.5 24.8 5.8e-07 30.1 0.1 7.5 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14158.1 - 9.1e-14 51.5 1.8 0.019 15.2 0.0 5.7 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14158.1 - 2.3e-11 43.1 6.6 0.025 13.3 0.1 4.7 2 2 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO14158.1 - 5.2e-05 22.7 6.5 0.027 13.8 0.3 4.2 3 1 1 4 4 4 2 WD40-like domain TBK1_ULD PF18396.1 ETO14158.1 - 0.038 13.9 0.0 13 5.8 0.0 3.5 3 0 0 3 3 3 0 TANK binding kinase 1 ubiquitin-like domain DUF1481 PF07356.12 ETO14158.1 - 0.2 11.4 0.9 0.73 9.6 0.2 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1481) WD40 PF00400.32 ETO14159.1 - 1e-37 127.5 33.9 8.3e-07 29.6 1.7 8.3 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14159.1 - 3.3e-11 43.3 3.4 0.16 12.3 0.0 5.6 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14159.1 - 9.4e-08 31.1 12.2 0.21 10.2 0.8 5.7 3 2 2 6 6 6 5 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO14159.1 - 4.5e-06 27.3 1.8 4.5e-06 27.3 1.8 2.7 3 0 0 3 3 3 1 TRAF-type zinc finger WD40_like PF17005.5 ETO14159.1 - 1.2e-05 24.8 8.0 0.056 12.8 0.1 4.5 2 2 2 4 4 4 2 WD40-like domain DUF1664 PF07889.12 ETO14159.1 - 8.3 6.5 9.3 17 5.5 9.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) DUF1943 PF09172.11 ETO14160.1 - 1.8e-06 27.4 0.6 9.1e-06 25.1 0.5 1.5 1 1 1 2 2 2 2 Domain of unknown function (DUF1943) DUF2490 PF10677.9 ETO14160.1 - 0.011 15.7 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2490) DUF481 PF04338.12 ETO14160.1 - 0.014 15.4 0.2 0.03 14.4 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function, DUF481 LEA_2 PF03168.13 ETO14160.1 - 0.069 13.7 6.5 1.1 9.8 2.3 3.1 1 1 2 3 3 3 0 Late embryogenesis abundant protein E1_DerP2_DerF2 PF02221.15 ETO14160.1 - 0.15 12.5 5.4 1.7 9.1 1.7 2.4 1 1 1 2 2 2 0 ML domain DUF1062 PF06353.12 ETO14160.1 - 0.18 12.6 10.1 3.3 8.5 5.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1062) Spore_YunB PF09560.10 ETO14160.1 - 0.42 10.7 10.3 2.3 8.3 5.6 2.9 1 1 1 2 2 2 0 Sporulation protein YunB (Spo_YunB) PulA_N1 PF17999.1 ETO14160.1 - 0.62 10.8 7.5 1.6 9.5 4.7 2.5 1 1 1 2 2 2 0 Pullulanase N1-terminal domain Integrin_alpha2 PF08441.12 ETO14160.1 - 1.4 7.7 6.2 6.4 5.5 0.7 2.0 1 1 1 2 2 2 0 Integrin alpha AMP-binding_C_2 PF14535.6 ETO14160.1 - 1.9 8.9 13.1 1.5 9.2 9.1 2.5 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain zf-CCCH_2 PF14608.6 ETO14161.1 - 4.4e-05 23.8 6.9 0.002 18.6 1.2 2.8 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger Menin PF05053.13 ETO14161.1 - 2.3 6.4 11.9 4 5.7 11.9 1.4 1 0 0 1 1 1 0 Menin MMR_HSR1 PF01926.23 ETO14164.1 - 2.3e-10 40.6 0.1 6e-10 39.2 0.1 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO14164.1 - 1.1e-09 38.1 0.0 4.3e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO14164.1 - 2.2e-05 24.5 0.6 0.007 16.3 0.1 2.4 1 1 0 2 2 2 2 RsgA GTPase Dynamin_N PF00350.23 ETO14164.1 - 0.0033 17.5 0.5 0.031 14.4 0.1 2.4 1 1 0 2 2 2 1 Dynamin family ATP_bind_1 PF03029.17 ETO14164.1 - 0.0053 16.6 0.0 3 7.6 0.0 2.5 2 0 0 2 2 2 2 Conserved hypothetical ATP binding protein FeoB_N PF02421.18 ETO14164.1 - 0.0059 16.1 0.4 0.33 10.5 0.1 2.6 2 1 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 ETO14164.1 - 0.0073 15.8 0.1 0.44 10.0 0.1 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family Ras PF00071.22 ETO14164.1 - 0.0095 15.6 0.0 2.2 7.9 0.0 2.4 2 0 0 2 2 2 2 Ras family DUF4771 PF15995.5 ETO14164.1 - 0.039 14.2 0.1 0.1 12.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) MMR_HSR1_Xtn PF16897.5 ETO14164.1 - 0.05 13.6 0.1 0.14 12.2 0.1 1.8 1 0 0 1 1 1 0 C-terminal region of MMR_HSR1 domain SRPRB PF09439.10 ETO14164.1 - 0.11 11.9 1.3 5 6.5 0.3 2.5 2 1 0 2 2 2 0 Signal recognition particle receptor beta subunit ALIX_LYPXL_bnd PF13949.6 ETO14165.1 - 4.8e-40 137.7 14.8 5.1e-40 137.6 14.8 1.0 1 0 0 1 1 1 1 ALIX V-shaped domain binding to HIV Snapin_Pallidin PF14712.6 ETO14165.1 - 0.018 15.4 1.9 0.018 15.4 1.9 3.7 2 2 1 3 3 3 0 Snapin/Pallidin DUF2203 PF09969.9 ETO14165.1 - 0.025 15.3 5.7 1.4 9.7 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Takusan PF04822.13 ETO14165.1 - 0.042 13.7 7.6 0.089 12.7 0.8 3.3 3 0 0 3 3 3 0 Takusan Laminin_II PF06009.12 ETO14165.1 - 0.15 12.1 10.4 0.46 10.5 4.0 2.5 2 1 0 2 2 2 0 Laminin Domain II YojJ PF10372.9 ETO14165.1 - 0.16 12.0 4.6 0.93 9.6 0.0 3.7 2 1 2 4 4 4 0 Bacterial membrane-spanning protein N-terminus DUF3585 PF12130.8 ETO14165.1 - 0.26 11.4 13.8 0.096 12.8 9.1 2.2 2 0 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Syntaxin_2 PF14523.6 ETO14165.1 - 0.27 11.6 19.6 5.9 7.3 11.4 2.8 1 1 1 2 2 2 0 Syntaxin-like protein LMBR1 PF04791.16 ETO14165.1 - 0.32 9.9 4.5 0.37 9.7 4.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4254 PF14063.6 ETO14165.1 - 0.36 10.6 7.2 1.7 8.4 5.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF4254) YkyA PF10368.9 ETO14165.1 - 0.38 10.4 20.1 29 4.3 20.2 3.0 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein Ntox28 PF15605.6 ETO14165.1 - 0.41 10.9 9.9 0.24 11.6 0.7 3.2 2 1 1 3 3 3 0 Bacterial toxin 28 DUF390 PF04094.14 ETO14165.1 - 0.41 8.9 1.9 0.49 8.6 1.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF390) Cytochrom_B562 PF07361.11 ETO14165.1 - 0.43 11.3 8.3 3.1 8.5 2.1 2.6 2 1 0 2 2 2 0 Cytochrome b562 DUF2205 PF10224.9 ETO14165.1 - 0.47 10.5 9.2 0.33 11.0 0.5 2.9 2 1 0 2 2 2 0 Short coiled-coil protein HMW1C_N PF18071.1 ETO14165.1 - 0.47 10.2 5.1 14 5.5 0.1 3.0 2 1 1 3 3 3 0 HMW1C N-terminal FapA PF03961.13 ETO14165.1 - 0.68 8.5 17.7 0.74 8.4 6.2 2.2 1 1 0 2 2 2 0 Flagellar Assembly Protein A Med30 PF11315.8 ETO14165.1 - 1.6 8.9 14.8 0.48 10.6 9.5 2.6 1 1 2 3 3 3 0 Mediator complex subunit 30 DUF1068 PF06364.12 ETO14165.1 - 1.8 8.4 7.4 1.7 8.5 6.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1068) HeLo PF14479.6 ETO14165.1 - 3 7.6 12.7 2.3 8.0 9.0 2.4 1 1 1 2 2 2 0 Prion-inhibition and propagation Ax_dynein_light PF10211.9 ETO14165.1 - 7.8 6.4 18.0 0.11 12.4 1.4 2.4 2 1 0 2 2 2 0 Axonemal dynein light chain ZapB PF06005.12 ETO14165.1 - 7.9 7.0 17.7 1.1 9.7 5.7 3.1 3 0 0 3 3 3 0 Cell division protein ZapB EF-G-binding_N PF07299.11 ETO14165.1 - 8.2 7.0 9.9 1.2 9.7 1.5 3.3 2 2 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DUF725 PF05267.12 ETO14165.1 - 9.7 6.2 13.8 7.6 6.5 2.3 3.5 2 2 0 2 2 2 0 Protein of unknown function (DUF725) RRM_1 PF00076.22 ETO14167.1 - 9.5e-23 79.8 1.2 2.4e-06 27.3 0.4 6.3 6 1 0 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ICAT PF06384.11 ETO14168.1 - 6.5e-12 45.5 1.4 1.9e-11 44.1 1.4 1.8 1 0 0 1 1 1 1 Beta-catenin-interacting protein ICAT GvpG PF05120.12 ETO14168.1 - 0.00044 20.2 1.2 0.00044 20.2 1.2 2.5 2 1 0 2 2 2 1 Gas vesicle protein G SWC7 PF17330.2 ETO14168.1 - 0.0059 16.6 0.5 0.017 15.2 0.4 1.8 1 1 0 1 1 1 1 SWR1 chromatin-remodelling complex, sub-unit Swc7 TraF_2 PF13729.6 ETO14168.1 - 0.099 12.0 1.4 0.14 11.6 1.3 1.6 1 1 0 1 1 1 0 F plasmid transfer operon, TraF, protein PG_binding_1 PF01471.18 ETO14168.1 - 0.11 12.7 2.5 0.53 10.5 0.2 2.5 2 0 0 2 2 2 0 Putative peptidoglycan binding domain HGD-D PF06050.13 ETO14168.1 - 0.16 11.7 2.2 0.22 11.2 2.0 1.3 1 1 0 1 1 1 0 2-hydroxyglutaryl-CoA dehydratase, D-component Plasmid_RAQPRD PF09686.10 ETO14168.1 - 0.43 10.8 4.6 2.4 8.4 0.0 3.1 2 2 1 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) DUF3452 PF11934.8 ETO14168.1 - 0.91 9.1 7.9 0.2 11.2 0.8 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF3452) LMBR1 PF04791.16 ETO14168.1 - 0.94 8.3 8.2 1.1 8.1 8.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein YtxH PF12732.7 ETO14168.1 - 5.8 7.5 8.8 1.5 9.4 1.9 2.6 2 1 0 2 2 2 0 YtxH-like protein SHR3_chaperone PF08229.11 ETO14169.1 - 0.034 13.1 0.0 0.034 13.1 0.0 2.9 3 0 0 3 3 3 0 ER membrane protein SH3 DUF3883 PF13020.6 ETO14169.1 - 0.039 14.0 0.8 0.14 12.2 0.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3883) DUF1501 PF07394.12 ETO14170.1 - 1.4 7.9 5.6 0.11 11.5 0.9 1.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1501) Spc24 PF08286.11 ETO14171.1 - 0.29 11.4 5.9 0.076 13.3 2.4 1.8 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Tmemb_cc2 PF10267.9 ETO14171.1 - 0.62 9.1 17.2 0.78 8.8 17.2 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Golgin_A5 PF09787.9 ETO14171.1 - 1.9 7.9 17.0 1.2 8.5 15.6 1.4 1 1 0 1 1 1 0 Golgin subfamily A member 5 TMPIT PF07851.13 ETO14171.1 - 9 5.4 6.5 13 4.9 6.5 1.2 1 0 0 1 1 1 0 TMPIT-like protein SNF2_N PF00176.23 ETO14172.1 - 1.2e-47 162.4 0.0 1.5e-47 162.0 0.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO14172.1 - 2.4e-09 37.4 0.2 6.5e-08 32.8 0.1 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO14172.1 - 6.4e-05 22.8 0.0 0.00014 21.7 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase SWI2_SNF2 PF18766.1 ETO14172.1 - 0.00035 20.3 0.1 0.0011 18.7 0.0 1.8 2 1 0 2 2 2 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 ETO14172.1 - 0.034 13.4 0.0 0.082 12.1 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) AAA_22 PF13401.6 ETO14172.1 - 0.058 13.7 0.2 0.22 11.8 0.0 2.2 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ETO14173.1 - 6.2e-18 65.5 0.4 1.4e-17 64.4 0.0 1.7 2 1 1 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO14173.1 - 2e-07 30.7 0.0 4.7e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain PELOTA_1 PF15608.6 ETO14173.1 - 0.058 13.3 0.2 0.15 12.0 0.2 1.6 1 0 0 1 1 1 0 PELOTA RNA binding domain DNA_pol_phi PF04931.13 ETO14173.1 - 0.18 9.8 2.8 0.14 10.2 1.5 1.3 2 0 0 2 2 2 0 DNA polymerase phi Mg_chelatase PF01078.21 ETO14174.1 - 0.013 14.9 0.6 0.032 13.6 0.1 1.8 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA PF00004.29 ETO14174.1 - 0.035 14.5 0.3 0.035 14.5 0.3 2.6 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) ERM PF00769.19 ETO14174.1 - 0.78 9.5 27.1 1.4 8.7 27.1 1.4 1 0 0 1 1 1 0 Ezrin/radixin/moesin family Membralin PF09746.9 ETO14174.1 - 1.6 7.6 9.4 2.6 7.0 9.4 1.4 1 0 0 1 1 1 0 Tumour-associated protein Helicase_C PF00271.31 ETO14175.1 - 7.2e-12 45.6 1.8 1.4e-08 35.0 0.2 3.4 2 1 0 2 2 2 2 Helicase conserved C-terminal domain Presenilin PF01080.17 ETO14175.1 - 0.79 8.4 7.4 4.1 6.1 2.8 2.1 2 0 0 2 2 2 0 Presenilin G-alpha PF00503.20 ETO14176.1 - 0.018 14.2 3.5 0.021 14.0 3.5 1.0 1 0 0 1 1 1 0 G-protein alpha subunit Mitofilin PF09731.9 ETO14176.1 - 0.019 13.9 11.2 0.024 13.5 11.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein tRNA-synt_1d PF00750.19 ETO14176.1 - 0.039 12.9 5.0 0.05 12.6 5.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (R) Viral_DNA_Zn_bi PF03728.13 ETO14176.1 - 0.084 13.4 2.4 0.16 12.5 2.4 1.5 1 0 0 1 1 1 0 Viral DNA-binding protein, zinc binding domain CENP-H PF05837.12 ETO14176.1 - 0.12 12.8 15.4 0.2 12.1 15.4 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FAM176 PF14851.6 ETO14176.1 - 0.42 10.3 3.6 0.76 9.4 3.6 1.4 1 0 0 1 1 1 0 FAM176 family Takusan PF04822.13 ETO14177.1 - 0.06 13.2 0.0 0.29 11.0 0.0 1.9 2 0 0 2 2 2 0 Takusan Gly_transf_sug PF04488.15 ETO14178.1 - 3.3e-10 40.5 0.4 8.2e-10 39.2 0.4 1.6 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ETO14178.1 - 0.00012 21.6 0.1 0.00023 20.7 0.0 1.4 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein Atg14 PF10186.9 ETO14179.1 - 0.0028 16.8 3.8 0.0032 16.6 3.8 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Bromo_TP PF07524.13 ETO14179.1 - 0.038 14.0 0.1 0.094 12.7 0.1 1.7 2 0 0 2 2 2 0 Bromodomain associated DnaJ_C PF01556.18 ETO14180.1 - 4.3e-17 62.6 0.3 8.7e-17 61.6 0.3 1.5 1 1 0 1 1 1 1 DnaJ C terminal domain DUF2379 PF09543.10 ETO14181.1 - 0.081 13.1 3.2 3.8 7.7 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2379) G-alpha PF00503.20 ETO14184.1 - 8e-50 170.0 8.2 8e-50 170.0 8.2 3.5 1 1 1 2 2 2 1 G-protein alpha subunit Arf PF00025.21 ETO14184.1 - 6.3e-07 29.0 2.2 6.4e-05 22.5 0.0 2.8 2 0 0 2 2 2 2 ADP-ribosylation factor family DUF3446 PF11928.8 ETO14184.1 - 1.9 8.8 8.3 5.5 7.4 8.3 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain Ribosomal_60s PF00428.19 ETO14185.1 - 7.4e-14 52.1 5.9 1.3e-13 51.3 5.9 1.4 1 1 0 1 1 1 1 60s Acidic ribosomal protein Sirohm_synth_M PF14824.6 ETO14185.1 - 0.043 13.3 0.4 0.095 12.2 0.4 1.6 1 0 0 1 1 1 0 Sirohaem biosynthesis protein central BCL_N PF04714.13 ETO14186.1 - 0.37 10.9 3.5 0.52 10.4 0.2 2.7 3 0 0 3 3 3 0 BCL7, N-terminal conserver region Ank PF00023.30 ETO14188.1 - 2e-17 62.8 0.1 4.1e-09 36.5 0.0 4.5 4 1 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 ETO14188.1 - 1.6e-16 60.6 0.1 4.5e-15 56.0 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO14188.1 - 3.3e-16 59.1 0.2 8.4e-07 29.1 0.0 3.4 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO14188.1 - 5.4e-16 58.7 1.6 1.1e-08 35.4 0.1 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) SAM_1 PF00536.30 ETO14188.1 - 2.2e-13 50.4 0.2 1.6e-12 47.6 0.1 2.1 1 1 1 2 2 2 1 SAM domain (Sterile alpha motif) Ank_3 PF13606.6 ETO14188.1 - 2.8e-12 45.7 0.1 8.2e-06 25.8 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat SAM_2 PF07647.17 ETO14188.1 - 5.1e-12 45.7 0.1 9e-12 44.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Tic22 PF04278.12 ETO14188.1 - 0.036 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Tic22-like family Spore_III_AF PF09581.10 ETO14188.1 - 2.7 8.0 13.9 1.5 8.8 11.6 1.8 1 1 1 2 2 2 0 Stage III sporulation protein AF (Spore_III_AF) SLATT_5 PF18160.1 ETO14189.1 - 0.16 11.3 2.2 0.29 10.4 2.2 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 RR_TM4-6 PF06459.12 ETO14189.1 - 3.2 7.5 11.8 1.8 8.4 9.6 1.5 1 1 1 2 2 2 0 Ryanodine Receptor TM 4-6 DUF3342 PF11822.8 ETO14190.1 - 1.1e-27 96.0 1.4 2.8e-27 94.8 1.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3342) BTB PF00651.31 ETO14190.1 - 3.6e-05 24.0 0.4 8.6e-05 22.7 0.4 1.6 1 0 0 1 1 1 1 BTB/POZ domain ATR13 PF16829.5 ETO14190.1 - 0.013 15.8 0.2 0.041 14.2 0.0 1.9 2 0 0 2 2 2 0 Avirulence protein ATR13, RxLR effector Phage_FRD3 PF05798.11 ETO14190.1 - 0.14 12.5 0.3 0.28 11.5 0.3 1.5 1 0 0 1 1 1 0 Bacteriophage FRD3 protein Ras PF00071.22 ETO14191.1 - 2.5e-32 111.7 0.1 4e-32 111.0 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO14191.1 - 8e-10 39.0 0.0 1.8e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase UMP1 PF05348.11 ETO14191.1 - 2e-05 24.8 0.1 3.5e-05 24.0 0.1 1.3 1 0 0 1 1 1 1 Proteasome maturation factor UMP1 Arf PF00025.21 ETO14191.1 - 0.00014 21.4 0.2 0.00029 20.4 0.2 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family FeoB_N PF02421.18 ETO14191.1 - 0.041 13.4 0.1 0.069 12.7 0.1 1.4 1 0 0 1 1 1 0 Ferrous iron transport protein B PAD PF03068.15 ETO14191.1 - 0.061 12.3 0.0 0.09 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) Pox_A9 PF04835.12 ETO14191.1 - 0.4 10.9 4.5 10 6.3 0.1 2.7 2 0 0 2 2 2 0 A9 protein conserved region DUF3007 PF11460.8 ETO14192.1 - 0.33 11.2 2.4 0.94 9.8 2.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) APC_N_CC PF16689.5 ETO14192.1 - 0.46 10.6 5.1 0.33 11.0 3.0 1.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain TSC22 PF01166.18 ETO14192.1 - 3.1 8.2 8.6 7.6 6.9 1.6 3.2 2 2 1 3 3 3 0 TSC-22/dip/bun family DUF3450 PF11932.8 ETO14192.1 - 5.1 6.3 10.3 9.6 5.4 10.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF2203 PF09969.9 ETO14192.1 - 5.8 7.7 10.7 0.35 11.6 4.5 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) EF-hand_7 PF13499.6 ETO14193.1 - 2.5e-12 47.1 6.9 6.2e-08 33.0 2.3 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO14193.1 - 9.7e-11 41.4 7.7 1.2e-06 28.2 0.8 3.2 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO14193.1 - 1.3e-09 36.9 12.0 0.0038 16.7 0.6 4.8 6 0 0 6 6 6 3 EF hand EF-hand_6 PF13405.6 ETO14193.1 - 7.7e-07 28.6 9.6 0.0056 16.5 1.1 4.8 4 2 1 5 5 5 2 EF-hand domain EF-hand_4 PF12763.7 ETO14193.1 - 0.00018 21.4 3.6 0.0054 16.7 0.8 2.1 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO14193.1 - 0.0076 16.6 1.1 0.023 15.0 0.3 2.0 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region TerB PF05099.13 ETO14193.1 - 0.0088 16.0 2.9 0.33 10.9 0.3 2.1 1 1 1 2 2 2 2 Tellurite resistance protein TerB Mu-like_Pro PF10123.9 ETO14193.1 - 0.0098 15.5 0.3 0.03 13.9 0.3 1.6 1 1 0 1 1 1 1 Mu-like prophage I protein Dockerin_1 PF00404.18 ETO14193.1 - 0.02 15.1 2.1 0.16 12.2 1.1 2.1 2 0 0 2 2 2 0 Dockerin type I domain Coat_X PF07552.11 ETO14193.1 - 0.059 13.2 0.0 6.4 6.7 0.0 2.2 2 0 0 2 2 2 0 Spore Coat Protein X and V domain DUF592 PF04574.13 ETO14193.1 - 0.088 12.6 1.1 0.16 11.7 0.5 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF592) VPS13 PF16908.5 ETO14193.1 - 0.11 12.3 0.2 1.7 8.4 0.1 2.0 1 1 1 2 2 2 0 Vacuolar sorting-associated protein 13, N-terminal EF-hand_5 PF13202.6 ETO14193.1 - 0.2 11.2 0.1 0.2 11.2 0.1 4.9 6 0 0 6 6 6 0 EF hand DUF2120 PF09893.9 ETO14193.1 - 0.52 10.4 5.1 1.8 8.7 0.6 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) Stc1 PF12898.7 ETO14195.1 - 0.5 11.0 7.3 0.16 12.5 4.3 1.8 1 1 1 2 2 2 0 Stc1 domain FBPase PF00316.20 ETO14196.1 - 3.4e-10 39.7 0.1 4.9e-10 39.2 0.1 1.3 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain YyzF PF14116.6 ETO14196.1 - 0.038 14.0 0.0 0.079 13.0 0.0 1.5 1 0 0 1 1 1 0 YyzF-like protein Herpes_UL14 PF03580.14 ETO14197.1 - 0.026 14.8 2.4 0.039 14.2 2.3 1.3 1 1 0 1 1 1 0 Herpesvirus UL14-like protein PspB PF06667.12 ETO14197.1 - 8.7 6.5 6.0 4.6 7.4 1.7 2.2 1 1 1 2 2 2 0 Phage shock protein B COG4 PF08318.12 ETO14198.1 - 9.7e-48 162.9 8.1 9.7e-48 162.9 8.1 2.0 2 0 0 2 2 2 1 COG4 transport protein DIL PF01843.19 ETO14198.1 - 0.00021 21.5 1.9 0.0018 18.5 1.9 2.6 1 1 0 1 1 1 1 DIL domain ING PF12998.7 ETO14198.1 - 0.018 15.6 0.4 0.17 12.5 0.4 2.7 1 0 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding MerR_2 PF13591.6 ETO14198.1 - 2.3 8.1 5.5 0.39 10.6 0.2 2.5 3 0 0 3 3 3 0 MerR HTH family regulatory protein Carb_kinase PF01256.17 ETO14199.1 - 7.4e-21 74.7 0.0 2.8e-09 36.8 0.0 3.2 2 1 0 2 2 2 2 Carbohydrate kinase PmrD PF11183.8 ETO14199.1 - 0.093 12.9 0.1 15 5.8 0.0 2.6 2 0 0 2 2 2 0 Polymyxin resistance protein PmrD CDC45 PF02724.14 ETO14201.1 - 4.5 5.4 12.9 5.1 5.3 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO14201.1 - 8.6 5.0 8.9 8.7 5.0 8.9 1.2 1 0 0 1 1 1 0 Presenilin Ion_trans PF00520.31 ETO14202.1 - 2.7e-13 49.7 19.5 5.8e-13 48.6 19.5 1.6 1 0 0 1 1 1 1 Ion transport protein DUF4369 PF14289.6 ETO14202.1 - 0.022 15.2 0.1 1 10.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4369) SWC7 PF17330.2 ETO14202.1 - 0.083 13.0 0.3 1.8 8.6 0.0 3.1 3 0 0 3 3 3 0 SWR1 chromatin-remodelling complex, sub-unit Swc7 G-alpha PF00503.20 ETO14203.1 - 5e-53 180.5 2.0 6.2e-53 180.2 2.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO14203.1 - 9.2e-13 48.0 0.3 1.4e-12 47.4 0.3 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO14203.1 - 0.0013 18.2 0.1 0.0021 17.5 0.1 1.3 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ETO14203.1 - 0.0062 16.7 0.7 0.011 16.0 0.2 1.7 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase IL6 PF00489.17 ETO14203.1 - 0.071 12.7 0.3 0.25 10.9 0.0 1.9 1 1 1 2 2 2 0 Interleukin-6/G-CSF/MGF family MMR_HSR1 PF01926.23 ETO14203.1 - 0.14 12.2 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase CD225 PF04505.12 ETO14204.1 - 0.058 13.5 0.1 0.058 13.5 0.1 2.0 2 0 0 2 2 2 0 Interferon-induced transmembrane protein cNMP_binding PF00027.29 ETO14205.1 - 7.7e-36 122.1 0.0 9.3e-18 64.1 0.0 3.3 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain RMI1_N PF08585.12 ETO14207.1 - 2.7e-29 102.5 0.0 1.7e-18 67.2 0.0 2.0 1 1 1 2 2 2 2 RecQ mediated genome instability protein Rad60-SLD PF11976.8 ETO14207.1 - 0.066 13.1 0.3 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DHHC PF01529.20 ETO14208.1 - 7.9e-30 103.7 15.7 1.5e-29 102.8 15.7 1.4 1 0 0 1 1 1 1 DHHC palmitoyltransferase Mem_trans PF03547.18 ETO14208.1 - 0.052 12.0 0.0 0.052 12.0 0.0 1.2 1 0 0 1 1 1 0 Membrane transport protein Macoilin PF09726.9 ETO14208.1 - 1.1 7.7 10.6 1.2 7.6 10.6 1.1 1 0 0 1 1 1 0 Macoilin family DUF1272 PF06906.11 ETO14208.1 - 6.5 6.9 11.5 10 6.3 7.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) SCAMP PF04144.13 ETO14209.1 - 5.2e-08 33.4 0.1 6.4e-08 33.1 0.1 1.1 1 0 0 1 1 1 1 SCAMP family Kinesin PF00225.23 ETO14211.1 - 6e-68 229.2 0.2 6e-68 229.2 0.2 1.7 2 0 0 2 2 2 1 Kinesin motor domain HR1 PF02185.16 ETO14211.1 - 0.0029 17.7 6.9 0.081 13.1 2.4 3.2 2 1 1 3 3 3 1 Hr1 repeat PspA_IM30 PF04012.12 ETO14211.1 - 0.01 15.5 4.2 0.01 15.5 4.2 2.8 2 1 0 2 2 2 0 PspA/IM30 family Laminin_II PF06009.12 ETO14211.1 - 0.012 15.6 8.8 0.026 14.6 0.3 2.9 3 0 0 3 3 3 0 Laminin Domain II bZIP_2 PF07716.15 ETO14211.1 - 0.023 14.8 1.6 0.023 14.8 1.6 2.9 3 0 0 3 3 2 0 Basic region leucine zipper SlyX PF04102.12 ETO14211.1 - 0.026 15.2 7.3 0.54 10.9 2.0 3.7 3 1 0 3 3 3 0 SlyX Tropomyosin PF00261.20 ETO14211.1 - 0.052 12.9 19.1 9.4 5.5 13.0 2.4 1 1 1 2 2 2 0 Tropomyosin Fib_alpha PF08702.10 ETO14211.1 - 0.061 13.5 7.9 1.8 8.8 0.1 2.9 3 0 0 3 3 2 0 Fibrinogen alpha/beta chain family Uds1 PF15456.6 ETO14211.1 - 0.46 10.6 15.4 17 5.6 12.7 2.9 2 1 0 2 2 2 0 Up-regulated During Septation DUF2730 PF10805.8 ETO14211.1 - 0.47 10.6 5.0 0.32 11.1 0.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2730) BLOC1_2 PF10046.9 ETO14211.1 - 0.58 10.5 10.2 0.13 12.5 0.8 3.1 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Seryl_tRNA_N PF02403.22 ETO14211.1 - 1.1 9.5 20.4 1.4 9.2 2.3 3.3 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF948 PF06103.11 ETO14211.1 - 1.2 9.5 7.5 0.79 10.0 0.8 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CDC45 PF02724.14 ETO14211.1 - 1.4 7.1 11.3 1.9 6.7 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein NPV_P10 PF05531.12 ETO14211.1 - 1.6 9.2 5.3 5.8 7.5 0.6 3.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein AATF-Che1 PF13339.6 ETO14211.1 - 2.6 8.7 14.3 0.73 10.5 3.2 2.7 2 1 1 3 3 2 0 Apoptosis antagonizing transcription factor Striatin PF08232.12 ETO14211.1 - 3.4 8.2 13.4 8 7.0 12.5 1.9 1 1 1 2 2 2 0 Striatin family DUF724 PF05266.14 ETO14211.1 - 4.4 7.1 18.7 0.19 11.5 0.6 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF724) Prefoldin PF02996.17 ETO14211.1 - 4.5 7.2 13.9 5.3 7.0 3.2 3.3 3 0 0 3 3 3 0 Prefoldin subunit Glutaredoxin2_C PF04399.13 ETO14211.1 - 6.3 6.6 6.0 5.8 6.8 0.4 3.2 4 0 0 4 4 4 0 Glutaredoxin 2, C terminal domain YabA PF06156.13 ETO14211.1 - 6.9 7.4 7.5 11 6.8 0.5 3.1 1 1 2 3 3 3 0 Initiation control protein YabA DHR10 PF18595.1 ETO14211.1 - 8.2 6.5 17.0 0.28 11.2 3.5 3.0 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain ZapB PF06005.12 ETO14212.1 - 0.0034 17.8 11.3 0.0034 17.8 11.3 6.4 1 1 5 6 6 6 3 Cell division protein ZapB PIF6 PF05341.11 ETO14212.1 - 0.03 14.4 0.1 0.067 13.3 0.1 1.6 1 0 0 1 1 1 0 Per os infectivity factor 6 ERM PF00769.19 ETO14212.1 - 0.45 10.3 69.9 1.2 8.9 49.1 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF1189 PF06691.11 ETO14212.1 - 2.1 7.8 5.2 1.1 8.7 2.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1189) Spc7 PF08317.11 ETO14212.1 - 2.8 6.7 67.2 7.7 5.3 22.9 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein MAD PF05557.13 ETO14212.1 - 4.7 5.5 70.3 2.4 6.4 14.1 2.1 1 1 1 2 2 2 0 Mitotic checkpoint protein Trypan_PARP PF05887.11 ETO14213.1 - 0.0011 19.0 0.9 0.002 18.1 0.9 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) DDHD PF02862.17 ETO14213.1 - 0.0023 18.1 5.2 0.05 13.7 2.7 2.2 2 0 0 2 2 2 1 DDHD domain Zip PF02535.22 ETO14213.1 - 0.004 16.4 2.2 0.039 13.2 0.3 2.4 2 0 0 2 2 2 1 ZIP Zinc transporter SAPS PF04499.15 ETO14213.1 - 0.0045 15.8 7.9 0.1 11.4 7.6 2.0 2 0 0 2 2 2 1 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO14213.1 - 0.014 13.7 12.5 0.18 10.1 12.7 2.0 2 0 0 2 2 2 0 CDC45-like protein EPL1 PF10513.9 ETO14213.1 - 0.073 13.5 17.1 1.8 8.9 12.8 2.3 2 0 0 2 2 2 0 Enhancer of polycomb-like Corazonin PF17308.2 ETO14213.1 - 0.084 13.2 22.7 0.15 12.5 11.5 2.4 2 0 0 2 2 2 0 Pro-corazonin PTPRCAP PF15713.5 ETO14213.1 - 0.11 12.8 15.5 0.054 13.8 8.6 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated CSG2 PF16965.5 ETO14213.1 - 0.14 11.1 9.6 1.4 7.8 3.3 2.9 3 0 0 3 3 3 0 Ceramide synthase regulator TRAP_alpha PF03896.16 ETO14213.1 - 0.32 10.2 8.6 1.5 8.0 6.1 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF5427 PF10310.9 ETO14213.1 - 0.61 9.0 19.6 0.019 13.9 12.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5427) DUF4637 PF15470.6 ETO14213.1 - 0.72 9.6 15.9 6.8 6.4 12.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF2464 PF10240.9 ETO14213.1 - 0.88 9.1 9.7 9.6 5.7 5.2 2.2 2 0 0 2 2 2 0 Multivesicular body subunit 12 Velvet PF11754.8 ETO14213.1 - 0.89 9.4 5.8 15 5.5 4.6 2.3 2 0 0 2 2 2 0 Velvet factor FAM60A PF15396.6 ETO14213.1 - 0.91 9.5 14.1 8.6 6.3 0.1 2.3 2 0 0 2 2 2 0 Protein Family FAM60A RNase_H2_suC PF08615.11 ETO14213.1 - 1.3 9.1 15.7 7.5e+03 -3.0 15.8 2.6 1 1 0 1 1 0 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) SLC12 PF03522.15 ETO14213.1 - 1.7 7.6 16.5 3.4 6.6 11.5 2.1 2 0 0 2 2 2 0 Solute carrier family 12 BAF1_ABF1 PF04684.13 ETO14213.1 - 2 7.4 27.5 2.5 7.0 17.4 2.1 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor Eapp_C PF10238.9 ETO14213.1 - 2.3 8.3 12.3 39 4.3 10.7 2.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein NST1 PF13945.6 ETO14213.1 - 2.7 8.1 35.3 1.9 8.6 21.7 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator PAP1 PF08601.10 ETO14213.1 - 3.7 7.2 21.7 4.4 6.9 13.3 2.2 2 0 0 2 2 2 0 Transcription factor PAP1 DUF2370 PF10176.9 ETO14213.1 - 4.3 6.9 9.4 14 5.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) DUF913 PF06025.12 ETO14213.1 - 4.6 6.1 9.7 8.5 5.2 6.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 ETO14213.1 - 7.1 6.4 19.9 0.29 10.9 12.1 2.0 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 ETO14213.1 - 8.3 5.4 17.4 6.8 5.7 13.4 2.1 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_S49_N PF08496.10 ETO14213.1 - 8.6 6.4 8.5 4.6 7.3 5.6 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF5308 PF17233.2 ETO14213.1 - 9.6 6.4 12.7 44 4.3 10.1 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5308) DUF2207 PF09972.9 ETO14214.1 - 0.0084 14.9 0.0 0.0093 14.8 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) zf-C3HC4_2 PF13923.6 ETO14215.1 - 3.6e-09 36.3 15.5 6.9e-09 35.4 15.5 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO14215.1 - 7.7e-09 35.3 10.9 1.3e-08 34.6 10.9 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO14215.1 - 9e-08 32.3 16.6 1.6e-07 31.5 16.6 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO14215.1 - 1.5e-07 31.2 14.7 2.6e-07 30.4 14.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO14215.1 - 2.6e-07 30.5 12.7 6.6e-07 29.2 12.7 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO14215.1 - 4.1e-07 29.8 12.9 6.7e-07 29.2 12.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO14215.1 - 4e-06 26.6 12.8 7.9e-06 25.6 12.8 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 U-box PF04564.15 ETO14215.1 - 4.5e-05 23.5 0.0 0.00043 20.4 0.0 2.1 2 0 0 2 2 2 1 U-box domain zf-rbx1 PF12678.7 ETO14215.1 - 0.00027 21.1 13.5 0.00059 20.1 13.5 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_4 PF15227.6 ETO14215.1 - 0.0033 17.5 16.1 0.0061 16.7 16.1 1.5 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Rtf2 PF04641.12 ETO14215.1 - 0.0044 16.4 0.2 0.0062 15.9 0.2 1.3 1 0 0 1 1 1 1 Rtf2 RING-finger YajC PF02699.15 ETO14215.1 - 0.012 15.5 3.9 0.022 14.7 3.9 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit zf-P11 PF03854.14 ETO14215.1 - 0.017 14.7 10.2 0.035 13.8 10.2 1.5 1 0 0 1 1 1 0 P-11 zinc finger Baculo_IE-1 PF05290.11 ETO14215.1 - 5.5 6.9 12.9 1.5 8.8 8.5 2.0 2 0 0 2 2 2 0 Baculovirus immediate-early protein (IE-0) ERp29 PF07749.12 ETO14216.1 - 1.4e-25 90.0 0.3 2.4e-25 89.3 0.3 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain ERp29_N PF07912.13 ETO14216.1 - 1.1e-12 48.3 0.0 2e-12 47.3 0.0 1.5 1 0 0 1 1 1 1 ERp29, N-terminal domain SAM_2 PF07647.17 ETO14218.1 - 3.3e-05 23.9 0.1 5.6e-05 23.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_11 PF13414.6 ETO14219.1 - 1.2e-12 47.3 13.1 0.00019 21.0 1.1 4.9 4 1 1 5 5 5 3 TPR repeat TPR_17 PF13431.6 ETO14219.1 - 9.2e-09 35.1 1.9 1 9.9 0.1 5.4 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14219.1 - 1.4e-07 31.0 15.8 0.026 14.4 0.2 6.3 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14219.1 - 3.5e-07 29.8 15.4 0.00074 19.4 0.2 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO14219.1 - 5.6e-06 26.8 6.6 0.002 18.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO14219.1 - 0.0026 18.4 3.6 0.061 14.2 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14219.1 - 0.082 13.6 4.4 0.84 10.3 3.0 3.1 3 1 0 3 3 2 0 Tetratricopeptide repeat Presenilin PF01080.17 ETO14219.1 - 0.094 11.5 29.0 0.0048 15.7 6.8 2.3 2 0 0 2 2 2 0 Presenilin TPR_8 PF13181.6 ETO14219.1 - 1.8 8.9 0.0 1.8 8.9 0.0 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat Macoilin PF09726.9 ETO14219.1 - 3.8 5.9 33.3 0.005 15.5 14.7 2.1 2 0 0 2 2 2 0 Macoilin family CCSAP PF15748.5 ETO14219.1 - 4 7.5 34.9 1.4 9.0 12.9 2.3 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated EST1 PF10374.9 ETO14221.1 - 0.014 16.0 6.0 0.024 15.3 3.2 2.5 2 0 0 2 2 2 0 Telomerase activating protein Est1 XRN_N PF03159.18 ETO14221.1 - 0.097 12.1 3.6 0.089 12.2 2.1 1.8 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus SPOB_a PF14689.6 ETO14221.1 - 0.18 11.5 4.4 0.25 11.1 0.9 3.1 2 1 1 3 3 3 0 Sensor_kinase_SpoOB-type, alpha-helical domain Citrate_synt PF00285.21 ETO14221.1 - 0.18 10.8 0.4 5.7 5.9 0.1 2.4 2 1 0 2 2 2 0 Citrate synthase, C-terminal domain BSP_II PF05432.11 ETO14221.1 - 0.28 10.8 17.7 0.4 10.3 17.7 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NTS PF15447.6 ETO14221.1 - 0.52 10.9 4.6 19 5.9 0.1 4.1 3 0 0 3 3 3 0 N-terminal segments of PfEMP1 DNA_pol_phi PF04931.13 ETO14221.1 - 0.77 7.8 20.0 1.3 7.0 20.0 1.4 1 0 0 1 1 1 0 DNA polymerase phi TERB2 PF15101.6 ETO14221.1 - 0.89 9.6 7.3 1.9 8.5 7.3 1.5 1 0 0 1 1 1 0 Telomere-associated protein TERB2 MRNIP PF15749.5 ETO14221.1 - 0.89 10.3 8.6 2.6 8.8 8.6 1.9 1 0 0 1 1 1 0 MRN-interacting protein Sporozoite_P67 PF05642.11 ETO14221.1 - 1.9 6.5 9.0 3.4 5.7 9.0 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Snurportin1 PF11538.8 ETO14221.1 - 2.5 8.3 6.9 23 5.3 0.1 3.5 3 0 0 3 3 3 0 Snurportin1 ALMT PF11744.8 ETO14221.1 - 3 6.6 6.6 4.6 6.0 6.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF913 PF06025.12 ETO14221.1 - 3.7 6.4 10.5 3.5 6.5 8.2 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4976 PF16347.5 ETO14221.1 - 4.3 7.6 8.2 2.6 8.4 0.4 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4976) Presenilin PF01080.17 ETO14221.1 - 4.8 5.8 8.9 6.5 5.4 8.9 1.2 1 0 0 1 1 1 0 Presenilin CCDC53 PF10152.9 ETO14221.1 - 6.3 7.2 13.6 4.8 7.6 11.5 1.8 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex RNA_pol_Rpc4 PF05132.14 ETO14221.1 - 6.8 7.1 9.6 4.5 7.7 7.7 1.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETO14221.1 - 8.1 4.6 14.3 10 4.3 14.3 1.3 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETO14221.1 - 8.8 6.0 15.8 0.79 9.4 10.4 1.9 2 0 0 2 2 2 0 FAM176 family Ras PF00071.22 ETO14222.1 - 1.5e-16 60.4 0.8 3.9e-09 36.3 0.3 2.7 1 1 1 2 2 2 2 Ras family G-alpha PF00503.20 ETO14222.1 - 0.31 10.2 5.6 0.4 9.8 5.6 1.0 1 0 0 1 1 1 0 G-protein alpha subunit PPR_2 PF13041.6 ETO14223.1 - 2.7e-12 46.7 1.7 5.6e-09 36.0 0.9 3.0 3 0 0 3 3 3 2 PPR repeat family PPR PF01535.20 ETO14223.1 - 6.3e-06 26.1 2.1 0.053 13.8 0.9 3.8 3 0 0 3 3 3 2 PPR repeat PPR_3 PF13812.6 ETO14223.1 - 0.00058 19.9 1.4 0.0026 17.8 0.6 2.4 1 1 1 2 2 2 2 Pentatricopeptide repeat domain ANAPC3 PF12895.7 ETO14223.1 - 0.00067 19.8 0.1 0.0022 18.2 0.1 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_1 PF00515.28 ETO14223.1 - 0.0099 15.7 0.1 1.4 8.9 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3523 PF12037.8 ETO14223.1 - 0.016 14.6 0.1 0.033 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) TPR_12 PF13424.6 ETO14223.1 - 0.049 13.9 0.2 8.1 6.8 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14223.1 - 0.11 12.7 0.0 9.4 6.6 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14223.1 - 0.14 12.1 0.1 8.5 6.4 0.0 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14223.1 - 0.14 12.5 0.6 31 5.1 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CHIP_TPR_N PF18391.1 ETO14223.1 - 0.94 10.3 5.0 0.49 11.2 1.6 2.3 2 0 0 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain SCAMP PF04144.13 ETO14225.1 - 6.3e-11 42.9 0.0 7.9e-11 42.6 0.0 1.1 1 0 0 1 1 1 1 SCAMP family LRR_6 PF13516.6 ETO14226.1 - 3.6e-19 67.1 34.5 0.0008 19.3 0.2 9.0 11 0 0 11 11 11 7 Leucine Rich repeat LRR_8 PF13855.6 ETO14226.1 - 2.8e-08 33.4 18.9 0.03 14.1 0.3 7.7 4 4 1 5 5 5 3 Leucine rich repeat LRR_1 PF00560.33 ETO14226.1 - 2.6e-07 30.2 19.6 1.3 9.8 0.1 9.2 10 0 0 10 10 10 3 Leucine Rich Repeat LRR_4 PF12799.7 ETO14226.1 - 3.9e-07 30.3 30.9 0.0016 18.8 1.6 6.9 4 3 3 7 7 7 3 Leucine Rich repeats (2 copies) CLZ PF16526.5 ETO14228.1 - 0.029 14.7 6.4 0.029 14.7 6.4 3.7 3 1 1 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels FUSC PF04632.12 ETO14228.1 - 0.58 8.6 1.3 0.75 8.3 1.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF4957 PF16318.5 ETO14229.1 - 0.12 12.3 1.4 0.36 10.8 1.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4957) ZapB PF06005.12 ETO14230.1 - 0.0043 17.5 89.3 0.1 13.0 8.2 7.8 3 2 4 7 7 7 5 Cell division protein ZapB ATG16 PF08614.11 ETO14230.1 - 0.0072 16.6 81.3 0.013 15.7 8.9 4.3 2 1 2 4 4 4 3 Autophagy protein 16 (ATG16) APG6_N PF17675.1 ETO14230.1 - 0.012 16.2 88.5 1.3 9.6 23.0 4.9 2 1 2 4 4 4 0 Apg6 coiled-coil region bZIP_1 PF00170.21 ETO14230.1 - 0.033 14.3 1.3 0.033 14.3 1.3 8.6 5 2 3 8 8 8 0 bZIP transcription factor Spc7 PF08317.11 ETO14230.1 - 0.037 12.9 81.6 0.04 12.8 13.6 4.2 1 1 4 5 5 5 0 Spc7 kinetochore protein bZIP_2 PF07716.15 ETO14230.1 - 0.045 13.8 1.9 0.045 13.8 1.9 10.2 5 3 5 11 11 11 0 Basic region leucine zipper CALCOCO1 PF07888.11 ETO14230.1 - 0.1 11.5 73.4 0.062 12.2 10.0 3.9 2 1 1 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like Filament PF00038.21 ETO14230.1 - 0.25 10.9 72.6 0.055 13.0 52.7 2.9 1 1 1 2 2 2 0 Intermediate filament protein GAS PF13851.6 ETO14230.1 - 1.3 8.4 89.5 0.072 12.4 31.4 3.5 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding PRKG1_interact PF15898.5 ETO14230.1 - 6.3 7.8 75.1 1 10.3 12.8 5.3 3 2 2 5 5 5 0 cGMP-dependent protein kinase interacting domain SlyX PF04102.12 ETO14231.1 - 0.014 16.0 21.2 0.63 10.7 7.5 3.6 1 1 3 4 4 4 0 SlyX GAS PF13851.6 ETO14231.1 - 0.056 12.8 35.9 0.14 11.5 20.2 2.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Bap31_Bap29_C PF18035.1 ETO14231.1 - 0.067 13.2 0.6 0.067 13.2 0.6 4.1 2 2 2 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain ATG16 PF08614.11 ETO14231.1 - 0.1 12.8 27.7 0.14 12.3 13.7 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Seadorna_VP6 PF07407.11 ETO14231.1 - 0.12 11.3 3.1 0.14 11.1 3.1 1.2 1 0 0 1 1 1 0 Seadornavirus VP6 protein DegS PF05384.11 ETO14231.1 - 0.13 11.7 23.8 0.034 13.6 7.3 2.8 1 1 1 2 2 2 0 Sensor protein DegS CEP63 PF17045.5 ETO14231.1 - 0.2 11.6 28.9 0.67 9.8 28.9 1.7 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa ADIP PF11559.8 ETO14231.1 - 0.21 11.7 30.6 0.54 10.3 8.2 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Jnk-SapK_ap_N PF09744.9 ETO14231.1 - 0.23 11.7 27.8 1 9.5 27.2 1.9 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Sec20 PF03908.13 ETO14231.1 - 0.28 11.1 12.5 1.9 8.5 1.4 2.4 2 0 0 2 2 2 0 Sec20 GrpE PF01025.19 ETO14231.1 - 0.3 10.7 27.4 0.19 11.4 11.5 2.5 1 1 2 3 3 3 0 GrpE TPR_MLP1_2 PF07926.12 ETO14231.1 - 0.38 10.8 32.1 0.31 11.1 9.4 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FPP PF05911.11 ETO14231.1 - 0.41 8.8 28.6 0.44 8.7 28.6 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil She9_MDM33 PF05546.11 ETO14231.1 - 0.54 10.0 20.2 6.1 6.6 9.5 2.4 1 1 1 2 2 2 0 She9 / Mdm33 family CALCOCO1 PF07888.11 ETO14231.1 - 0.57 9.0 26.2 0.65 8.8 26.2 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like PhoU PF01895.19 ETO14231.1 - 0.87 10.1 7.5 0.61 10.6 0.7 2.2 1 1 1 2 2 2 0 PhoU domain Spc7 PF08317.11 ETO14231.1 - 0.93 8.3 31.8 0.59 9.0 13.6 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein PSII_Pbs27 PF13326.6 ETO14231.1 - 1.2 9.5 9.7 1.9 8.8 5.3 2.0 1 1 1 2 2 2 0 Photosystem II Pbs27 ZapB PF06005.12 ETO14231.1 - 1.2 9.6 32.2 2.1 8.9 12.7 3.0 1 1 1 2 2 2 0 Cell division protein ZapB Fez1 PF06818.15 ETO14231.1 - 1.5 9.3 26.8 2.7 8.4 26.8 1.4 1 1 0 1 1 1 0 Fez1 Exonuc_VII_L PF02601.15 ETO14231.1 - 1.7 8.1 18.3 2.3 7.7 18.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 ETO14231.1 - 1.9 8.7 24.1 5.1 7.3 13.8 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DivIC PF04977.15 ETO14231.1 - 2.2 8.1 29.8 2 8.2 8.1 3.9 1 1 3 4 4 4 0 Septum formation initiator LOH1CR12 PF10158.9 ETO14231.1 - 3 7.9 14.9 0.61 10.1 2.5 2.1 1 1 1 2 2 2 0 Tumour suppressor protein NPV_P10 PF05531.12 ETO14231.1 - 4.6 7.8 16.1 2.7 8.5 3.9 2.9 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TMF_TATA_bd PF12325.8 ETO14231.1 - 5.2 7.3 27.3 3.1 8.0 17.8 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Cas_DxTHG PF09455.10 ETO14231.1 - 5.7 6.4 14.6 6.8 6.2 14.6 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family UPF0242 PF06785.11 ETO14231.1 - 6.6 6.8 33.2 10 6.2 12.0 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Rho_Binding PF08912.11 ETO14231.1 - 6.8 7.6 31.6 5.3 7.9 4.8 3.8 1 1 3 4 4 4 0 Rho Binding Acetyltransf_11 PF13720.6 ETO14231.1 - 9.6 6.7 7.5 7.1 7.2 1.7 2.8 1 1 1 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Mod_r PF07200.13 ETO14231.1 - 9.7 6.3 29.0 14 5.8 11.7 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF4407 PF14362.6 ETO14232.1 - 0.00095 18.6 7.2 0.00095 18.6 7.2 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) ERM PF00769.19 ETO14232.1 - 0.073 12.9 39.2 0.73 9.6 15.4 2.1 2 0 0 2 2 2 0 Ezrin/radixin/moesin family DUF3021 PF11457.8 ETO14232.1 - 0.13 12.6 0.6 0.54 10.6 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) DAO PF01266.24 ETO14232.1 - 0.29 10.7 0.1 0.44 10.1 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Arc_PepC_II PF06847.11 ETO14232.1 - 0.52 10.9 2.8 4.1 8.0 0.1 2.8 2 1 1 3 3 3 0 Archaeal Peptidase A24 C-terminus Type II FHIPEP PF00771.20 ETO14232.1 - 1.8 6.9 7.8 0.04 12.4 0.5 1.7 2 0 0 2 2 2 0 FHIPEP family Nre_C PF04895.12 ETO14232.1 - 3.7 7.5 5.7 3.6 7.6 1.0 2.6 2 0 0 2 2 2 0 Archaeal Nre, C-terminal DUF687 PF05095.12 ETO14234.1 - 0.0046 15.5 1.3 0.0065 15.0 1.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF687) Cas_Cas6 PF01881.16 ETO14234.1 - 0.075 13.6 0.3 0.12 12.9 0.3 1.3 1 0 0 1 1 1 0 CRISPR associated protein Cas6 PDZ PF00595.24 ETO14235.1 - 1.8e-05 25.0 0.0 5.3e-05 23.5 0.0 1.8 1 1 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO14235.1 - 0.0002 21.1 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 PDZ domain zf-ANAPC11 PF12861.7 ETO14235.1 - 0.013 15.5 4.0 0.035 14.1 4.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn-ribbon_8 PF09723.10 ETO14235.1 - 0.036 14.2 0.4 1.7 8.8 0.1 2.5 2 0 0 2 2 2 0 Zinc ribbon domain PDZ_2 PF13180.6 ETO14235.1 - 0.085 13.2 0.0 0.48 10.8 0.0 2.3 3 0 0 3 3 3 0 PDZ domain UPF0547 PF10571.9 ETO14235.1 - 0.31 11.2 7.1 0.35 11.0 0.2 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 Ogr_Delta PF04606.12 ETO14235.1 - 0.61 10.1 4.2 24 5.0 0.1 3.0 2 0 0 2 2 2 0 Ogr/Delta-like zinc finger zf-ribbon_3 PF13248.6 ETO14235.1 - 0.99 8.9 3.0 0.79 9.2 0.2 2.1 2 0 0 2 2 2 0 zinc-ribbon domain zinc-ribbons_6 PF07191.12 ETO14235.1 - 5.7 7.0 6.3 7 6.7 1.9 2.3 1 1 1 2 2 2 0 zinc-ribbons zf-LITAF-like PF10601.9 ETO14235.1 - 7.2 7.0 10.1 50 4.3 10.1 2.4 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain dDENN PF03455.19 ETO14236.1 - 0.0033 17.4 2.6 0.19 11.7 0.1 2.6 2 0 0 2 2 2 2 dDENN domain YMF19 PF02326.15 ETO14236.1 - 0.16 12.8 2.2 7.2 7.5 0.2 3.0 3 0 0 3 3 3 0 Plant ATP synthase F0 Kelch_6 PF13964.6 ETO14237.1 - 3.9e-10 39.6 5.9 7.4e-05 22.9 0.1 4.6 5 1 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO14237.1 - 1.6e-08 34.3 4.1 0.0026 17.7 0.7 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO14237.1 - 2e-07 30.5 8.9 0.0055 16.3 1.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO14237.1 - 2.2e-07 31.0 0.7 0.00039 20.6 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO14237.1 - 1.3e-06 28.3 1.8 2.8e-05 24.0 0.1 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14237.1 - 0.1 12.6 4.8 1.2 9.3 0.1 3.9 4 0 0 4 4 4 0 Kelch motif CarboxypepD_reg PF13620.6 ETO14238.1 - 5e-13 49.1 0.0 1.2e-06 28.7 0.0 3.3 3 1 0 3 3 3 2 Carboxypeptidase regulatory-like domain CarbopepD_reg_2 PF13715.6 ETO14238.1 - 2.1e-08 34.1 0.0 0.0076 16.2 0.0 2.9 2 0 0 2 2 2 2 CarboxypepD_reg-like domain SdrD_B PF17210.3 ETO14238.1 - 0.0006 20.0 0.0 0.0019 18.4 0.0 1.9 1 1 0 1 1 1 1 SdrD B-like domain Y_Y_Y PF07495.13 ETO14238.1 - 0.0054 16.7 0.0 0.013 15.4 0.0 1.6 1 0 0 1 1 1 1 Y_Y_Y domain MAP7 PF05672.11 ETO14238.1 - 0.013 15.2 24.2 0.022 14.4 24.2 1.3 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Bac_luciferase PF00296.20 ETO14238.1 - 0.045 13.2 0.6 0.071 12.5 0.6 1.2 1 0 0 1 1 1 0 Luciferase-like monooxygenase Myco_19_kDa PF05481.12 ETO14238.1 - 0.076 13.3 0.3 0.14 12.4 0.3 1.5 1 0 0 1 1 1 0 Mycobacterium 19 kDa lipoprotein antigen fn3_3 PF14686.6 ETO14238.1 - 0.079 12.8 0.7 7.8 6.4 0.0 3.0 3 0 0 3 3 3 0 Polysaccharide lyase family 4, domain II Dioxygenase_C PF00775.21 ETO14238.1 - 0.15 11.5 0.1 6.1 6.2 0.0 2.4 1 1 1 2 2 2 0 Dioxygenase CEP19 PF14933.6 ETO14238.1 - 0.29 11.4 8.4 0.82 10.0 8.4 1.7 1 0 0 1 1 1 0 CEP19-like protein CLN3 PF02487.17 ETO14238.1 - 0.3 10.1 0.7 0.44 9.5 0.7 1.2 1 0 0 1 1 1 0 CLN3 protein D5_N PF08706.11 ETO14238.1 - 0.35 11.1 6.0 1.1 9.5 2.8 2.7 2 1 0 2 2 2 0 D5 N terminal like Exonuc_VII_L PF02601.15 ETO14238.1 - 0.49 9.9 3.9 1.3 8.5 2.8 2.0 2 0 0 2 2 2 0 Exonuclease VII, large subunit EMP24_GP25L PF01105.24 ETO14238.1 - 0.52 10.2 0.0 0.52 10.2 0.0 3.0 3 0 0 3 3 2 0 emp24/gp25L/p24 family/GOLD APG6_N PF17675.1 ETO14238.1 - 0.57 10.7 23.2 1.2 9.6 23.2 1.6 1 0 0 1 1 1 0 Apg6 coiled-coil region Vma12 PF11712.8 ETO14238.1 - 1.6 8.8 5.0 3.3 7.8 5.0 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase OmpH PF03938.14 ETO14238.1 - 1.9 8.8 19.6 3.9 7.8 19.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 ETO14238.1 - 2.6 7.3 7.2 4.7 6.5 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) 5_nucleotid PF05761.14 ETO14238.1 - 2.7 6.8 7.0 4.5 6.1 7.0 1.2 1 0 0 1 1 1 0 5' nucleotidase family UPF0242 PF06785.11 ETO14238.1 - 4 7.5 16.0 8.1 6.5 16.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Endonuc_Holl PF10107.9 ETO14238.1 - 5.8 6.7 11.4 0.88 9.4 7.2 1.7 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase WD40 PF00400.32 ETO14239.1 - 4.9e-39 131.6 13.1 1.5e-10 41.5 0.3 5.5 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14239.1 - 1.4e-15 57.3 1.8 0.00038 20.7 0.1 4.3 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14239.1 - 1.1e-10 41.1 0.4 0.0088 15.0 0.0 3.8 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO14239.1 - 6.6e-07 29.4 0.0 0.032 14.1 0.0 2.9 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO14239.1 - 1.2e-06 28.1 0.1 0.007 15.7 0.0 2.5 2 1 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO14239.1 - 2.2e-05 23.2 0.2 0.012 14.1 0.0 2.6 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO14239.1 - 0.00049 18.9 1.5 2.6 6.6 0.0 4.0 1 1 2 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO14239.1 - 0.0025 17.7 0.1 2.5 8.1 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO14239.1 - 0.011 14.5 2.4 1.6 7.4 0.1 2.9 1 1 2 3 3 3 0 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO14239.1 - 0.015 14.3 0.1 0.16 11.0 0.0 2.2 1 1 1 2 2 2 0 Coatomer WD associated region NHL PF01436.21 ETO14239.1 - 0.14 12.3 0.6 1.3 9.2 0.2 2.4 2 0 0 2 2 2 0 NHL repeat Proteasome_A_N PF10584.9 ETO14239.1 - 0.19 11.5 0.9 20 4.9 0.0 2.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature SAM_Ste50p PF09235.10 ETO14240.1 - 0.015 15.6 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif SAM_KSR1 PF13543.6 ETO14240.1 - 0.028 14.6 0.5 0.045 13.9 0.5 1.4 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 ArAE_2_N PF10337.9 ETO14240.1 - 0.18 10.8 2.0 0.22 10.5 2.0 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal Presenilin PF01080.17 ETO14240.1 - 0.22 10.2 0.9 0.2 10.4 0.9 1.1 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO14240.1 - 0.51 10.1 10.3 0.52 10.1 10.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ETO14240.1 - 5.9 5.8 8.6 8 5.3 8.5 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Ras PF00071.22 ETO14241.1 - 1e-20 74.0 0.1 1.2e-20 73.7 0.1 1.1 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETO14241.1 - 0.0013 18.2 0.0 0.0017 17.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO14241.1 - 0.087 12.3 0.0 0.12 11.9 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain K_trans PF02705.16 ETO14242.1 - 0.36 9.3 1.5 0.43 9.0 1.5 1.1 1 0 0 1 1 1 0 K+ potassium transporter GramPos_pilinD1 PF16555.5 ETO14242.1 - 0.45 10.7 7.6 0.72 10.0 7.6 1.2 1 0 0 1 1 1 0 Gram-positive pilin subunit D1, N-terminal domain Spore_coat_CotO PF14153.6 ETO14242.1 - 1.3 8.9 14.6 1 9.3 13.6 1.3 1 1 0 1 1 1 0 Spore coat protein CotO LMBR1 PF04791.16 ETO14242.1 - 1.5 7.6 6.1 1.8 7.4 6.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Nairo_nucleo PF02477.15 ETO14243.1 - 0.0066 15.3 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Nucleocapsid N protein DUF3295 PF11702.8 ETO14243.1 - 1.6 8.0 4.5 2.5 7.4 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) WD40 PF00400.32 ETO14244.1 - 6.3e-14 52.2 14.2 1.2e-06 29.1 0.3 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO14244.1 - 0.04 12.6 5.4 2 6.9 0.1 2.9 1 1 2 3 3 3 0 Nucleoporin Nup120/160 KduI PF04962.12 ETO14244.1 - 0.067 12.5 0.0 0.084 12.2 0.0 1.2 1 0 0 1 1 1 0 KduI/IolB family WD40 PF00400.32 ETO14245.1 - 2.3e-49 164.3 19.4 1.6e-09 38.2 0.4 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14245.1 - 1.7e-22 79.5 3.6 0.0052 17.1 0.0 7.5 3 1 5 8 8 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14245.1 - 8.9e-13 47.9 1.4 0.00049 19.2 0.0 5.7 2 1 3 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO14245.1 - 5.7e-11 41.8 4.2 0.034 12.8 0.0 5.2 1 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO14245.1 - 4.3e-09 36.1 17.4 0.0046 16.3 0.0 4.9 4 1 1 5 5 5 3 WD40-like domain Kelch_4 PF13418.6 ETO14245.1 - 0.00063 19.7 3.8 0.041 13.9 0.4 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Cytochrom_D1 PF02239.16 ETO14245.1 - 0.00086 17.9 0.1 0.035 12.6 0.0 2.7 2 1 2 4 4 4 2 Cytochrome D1 heme domain Kelch_1 PF01344.25 ETO14245.1 - 0.0018 17.8 3.6 0.67 9.6 0.3 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 ETO14245.1 - 0.0028 17.6 4.9 2.9 8.0 0.3 5.3 5 1 0 5 5 5 1 Kelch motif PQQ PF01011.21 ETO14245.1 - 0.0094 15.8 0.0 8.9 6.4 0.0 4.6 5 0 0 5 5 5 1 PQQ enzyme repeat PD40 PF07676.12 ETO14245.1 - 0.012 15.6 8.8 3.3 7.8 0.1 4.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO14245.1 - 0.037 13.3 0.8 14 4.9 0.0 3.8 2 2 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO14245.1 - 5 6.9 5.2 1e+02 2.7 0.4 3.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Connexin PF00029.19 ETO14247.1 - 0.08 12.7 0.3 0.09 12.5 0.3 1.2 1 0 0 1 1 1 0 Connexin Sec62 PF03839.16 ETO14247.1 - 0.14 11.7 5.6 0.17 11.4 5.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MAS20 PF02064.15 ETO14247.1 - 0.42 10.7 2.5 0.74 9.9 2.5 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor Sporozoite_P67 PF05642.11 ETO14247.1 - 5.7 4.9 6.1 7.2 4.6 6.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PRKCSH_1 PF13015.6 ETO14248.1 - 1.9e-07 30.9 0.6 2.9e-07 30.3 0.6 1.3 1 0 0 1 1 1 1 Glucosidase II beta subunit-like protein PRKCSH PF07915.13 ETO14248.1 - 0.00018 22.4 2.5 0.00018 22.4 2.5 2.9 3 0 0 3 3 3 1 Glucosidase II beta subunit-like protein ATP-synt_8 PF00895.20 ETO14248.1 - 2.3 8.7 7.2 8.5 6.9 0.0 2.9 2 1 0 2 2 2 0 ATP synthase protein 8 CDC27 PF09507.10 ETO14249.1 - 0.0076 15.7 20.6 0.0076 15.7 20.6 2.1 2 0 0 2 2 2 2 DNA polymerase subunit Cdc27 BSP_II PF05432.11 ETO14249.1 - 3.5 7.3 58.2 0.36 10.5 25.4 2.3 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SR-25 PF10500.9 ETO14249.1 - 7 6.2 45.5 0.041 13.5 18.3 2.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein PPP4R2 PF09184.11 ETO14249.1 - 8.3 5.9 56.7 4.3 6.9 20.1 2.2 2 0 0 2 2 2 0 PPP4R2 CCSAP PF15748.5 ETO14249.1 - 8.8 6.4 45.9 0.96 9.6 18.6 2.4 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated fn3_4 PF16794.5 ETO14252.1 - 0.086 12.8 1.1 0.15 12.0 0.8 1.5 2 0 0 2 2 2 0 Fibronectin-III type domain G-gamma PF00631.22 ETO14253.1 - 0.0023 17.9 0.5 0.0057 16.6 0.5 1.8 1 1 0 1 1 1 1 GGL domain PI3Ka PF00613.20 ETO14253.1 - 0.0073 15.7 7.0 0.23 10.9 1.6 2.3 1 1 1 2 2 2 2 Phosphoinositide 3-kinase family, accessory domain (PIK domain) DUF2621 PF11084.8 ETO14253.1 - 0.035 14.1 0.7 0.064 13.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) HPPK PF01288.20 ETO14253.1 - 0.037 14.5 0.8 0.063 13.8 0.8 1.6 1 0 0 1 1 1 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) PIN_2 PF10130.9 ETO14253.1 - 0.044 14.0 4.6 0.062 13.5 3.9 1.7 1 1 1 2 2 2 0 PIN domain ETC_C1_NDUFA5 PF04716.14 ETO14253.1 - 0.045 13.6 0.1 0.045 13.6 0.1 2.8 3 1 0 3 3 3 0 ETC complex I subunit conserved region Pterin_bind PF00809.22 ETO14253.1 - 0.1 12.2 1.7 0.15 11.7 1.1 1.4 1 1 0 1 1 1 0 Pterin binding enzyme NLE PF08154.12 ETO14253.1 - 0.13 12.8 2.7 0.67 10.5 0.2 2.9 2 1 1 3 3 3 0 NLE (NUC135) domain Lipase_chap PF03280.14 ETO14253.1 - 0.3 11.0 4.8 0.55 10.2 0.4 2.1 1 1 1 2 2 2 0 Proteobacterial lipase chaperone protein MCPsignal PF00015.21 ETO14253.1 - 0.44 10.3 7.9 3.7 7.3 1.1 2.4 1 1 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain LMBR1 PF04791.16 ETO14253.1 - 4 6.2 12.4 4.7 6.0 12.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3450 PF11932.8 ETO14253.1 - 7.8 5.7 14.3 1.8 7.8 7.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF16 PF01519.16 ETO14253.1 - 9.3 6.8 24.5 1.8 9.1 3.6 2.6 1 1 1 2 2 2 0 Protein of unknown function DUF16 zf-RING_2 PF13639.6 ETO14254.1 - 0.023 15.0 2.3 0.037 14.4 2.3 1.4 1 0 0 1 1 1 0 Ring finger domain Glyco_tran_28_C PF04101.16 ETO14254.1 - 0.2 11.6 0.9 0.48 10.4 0.0 2.1 2 0 0 2 2 2 0 Glycosyltransferase family 28 C-terminal domain IBR PF01485.21 ETO14254.1 - 0.32 11.3 5.5 0.73 10.1 5.5 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain zf-C3HC4_4 PF15227.6 ETO14254.1 - 0.33 11.1 2.9 0.83 9.9 2.9 1.6 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING CPSase_sm_chain PF00988.22 ETO14255.1 - 0.092 12.6 0.2 0.24 11.2 0.2 1.7 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase small chain, CPSase domain PPL5 PF18168.1 ETO14256.1 - 0.16 11.2 2.1 6 6.1 0.0 2.0 2 0 0 2 2 2 0 Prim-pol family 5 YojJ PF10372.9 ETO14256.1 - 0.32 11.1 0.1 0.32 11.1 0.1 2.3 2 1 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus ATP-synt_F PF01990.17 ETO14257.1 - 6.1e-26 90.6 0.0 1.3e-25 89.6 0.0 1.6 1 1 0 1 1 1 1 ATP synthase (F/14-kDa) subunit EPF PF17181.4 ETO14258.1 - 0.014 15.3 0.8 2.8 8.0 0.0 2.4 2 0 0 2 2 2 0 Epidermal patterning factor proteins DUF3698 PF12479.8 ETO14258.1 - 0.11 13.1 0.5 0.19 12.3 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3698) DUF3201 PF11447.8 ETO14260.1 - 0.032 13.8 0.0 0.071 12.6 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3201) G-alpha PF00503.20 ETO14261.1 - 5.1e-56 190.4 3.2 6.6e-56 190.0 3.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO14261.1 - 1e-11 44.6 0.1 1.8e-07 30.8 0.0 2.6 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO14261.1 - 0.00055 20.0 0.2 0.25 11.4 0.1 2.6 2 1 0 2 2 2 2 50S ribosome-binding GTPase Roc PF08477.13 ETO14261.1 - 0.0015 18.8 0.1 1.9 8.7 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ETO14261.1 - 0.074 13.4 0.0 0.11 12.9 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ETO14261.1 - 0.15 11.4 0.1 0.36 10.1 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family Thioredoxin_7 PF13899.6 ETO14262.1 - 1.1e-08 35.1 0.2 3.4e-08 33.6 0.2 1.9 1 1 0 1 1 1 1 Thioredoxin-like AAA_9 PF12781.7 ETO14264.1 - 9.3e-05 21.7 0.0 0.00028 20.1 0.0 1.8 1 0 0 1 1 1 1 ATP-binding dynein motor region Thioredoxin_12 PF18400.1 ETO14264.1 - 0.11 12.4 0.0 0.22 11.3 0.0 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Arm PF00514.23 ETO14265.1 - 4.1e-23 80.6 4.2 4.4e-12 45.6 0.7 3.4 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO14265.1 - 3.1e-09 37.2 0.1 0.0021 18.5 0.1 2.6 2 0 0 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.6 ETO14265.1 - 3.5e-08 33.7 0.2 1.3e-07 31.9 0.2 2.0 1 1 0 1 1 1 1 HEAT repeats HEAT PF02985.22 ETO14265.1 - 1.7e-06 27.8 3.5 0.00028 20.9 0.1 3.4 4 0 0 4 4 3 1 HEAT repeat Cnd1 PF12717.7 ETO14265.1 - 0.00082 19.4 0.1 0.0025 17.9 0.0 1.9 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETO14265.1 - 0.0022 16.7 0.0 0.011 14.3 0.0 1.9 1 1 0 1 1 1 1 Adaptin N terminal region CLASP_N PF12348.8 ETO14265.1 - 0.024 14.2 0.0 0.044 13.3 0.0 1.4 1 0 0 1 1 1 0 CLASP N terminal Hormone_1 PF00103.20 ETO14265.1 - 0.051 13.3 3.4 3.3 7.4 0.1 2.6 3 0 0 3 3 3 0 Somatotropin hormone family Arm_3 PF16186.5 ETO14265.1 - 0.051 13.1 1.3 2.9 7.5 0.8 2.6 2 0 0 2 2 2 0 Atypical Arm repeat HEAT_PBS PF03130.16 ETO14265.1 - 0.092 13.5 0.1 0.41 11.5 0.1 2.2 1 1 0 1 1 1 0 PBS lyase HEAT-like repeat Secretin_N_2 PF07655.13 ETO14265.1 - 0.11 13.0 1.9 0.2 12.2 1.9 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Gcn1_N PF12074.8 ETO14265.1 - 0.11 11.7 0.3 0.41 9.9 0.2 1.7 1 1 1 2 2 2 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal adh_short PF00106.25 ETO14267.1 - 2e-17 63.3 0.0 7e-16 58.3 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO14267.1 - 1.2e-07 31.5 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO14267.1 - 4.7e-07 29.9 0.1 1.2e-06 28.5 0.1 1.6 1 1 0 1 1 1 1 KR domain RRN3 PF05327.11 ETO14267.1 - 0.08 11.5 6.6 0.14 10.6 6.6 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO14267.1 - 0.37 8.9 15.6 0.76 7.8 15.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO14267.1 - 1.7 6.8 12.3 0.061 11.6 6.3 1.5 2 0 0 2 2 2 0 CDC45-like protein Pkinase PF00069.25 ETO14269.1 - 0.00076 18.9 0.2 0.018 14.5 0.0 2.6 3 0 0 3 3 3 2 Protein kinase domain Pkinase PF00069.25 ETO14270.1 - 7.9e-35 120.5 0.1 1e-34 120.1 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14270.1 - 4.7e-24 85.1 0.2 7.6e-24 84.4 0.2 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO14270.1 - 6.6e-05 22.4 0.2 0.00017 21.0 0.0 1.8 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ETO14270.1 - 0.0011 18.9 0.0 0.0016 18.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO14270.1 - 0.0025 16.8 0.0 0.0042 16.1 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ETO14270.1 - 0.003 16.7 1.5 0.0044 16.1 0.1 1.9 2 0 0 2 2 2 1 Seadornavirus VP7 Pkinase_fungal PF17667.1 ETO14270.1 - 0.011 14.6 0.1 0.022 13.5 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase TGT PF01702.18 ETO14270.1 - 0.07 12.3 0.0 0.099 11.8 0.0 1.2 1 0 0 1 1 1 0 Queuine tRNA-ribosyltransferase BCMA-Tall_bind PF09257.10 ETO14271.1 - 0.15 12.2 0.4 2.4 8.3 0.0 2.4 2 0 0 2 2 2 0 BCMA, TALL-1 binding AcetylCoA_hyd_C PF13336.6 ETO14272.1 - 3.1e-58 196.1 0.1 4.4e-47 159.9 0.1 2.2 2 0 0 2 2 2 2 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 ETO14272.1 - 5.7e-21 75.4 0.0 1.2e-20 74.4 0.0 1.5 1 0 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain Ras PF00071.22 ETO14273.1 - 6.5e-51 172.1 1.2 2.6e-50 170.2 1.2 1.9 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO14273.1 - 1.8e-30 105.6 2.2 1.5e-29 102.6 0.1 3.1 2 2 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO14273.1 - 5.4e-10 39.0 0.9 2.9e-09 36.6 0.9 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO14273.1 - 0.0013 18.8 0.7 0.0082 16.2 0.0 2.4 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO14273.1 - 0.0026 17.7 0.9 0.14 12.1 0.0 2.7 2 1 1 3 3 3 1 RsgA GTPase GTP_EFTU PF00009.27 ETO14273.1 - 0.004 16.7 0.5 0.008 15.7 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_7 PF12775.7 ETO14273.1 - 0.016 14.7 0.0 0.042 13.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region FeoB_N PF02421.18 ETO14273.1 - 0.021 14.3 0.6 1.9 8.0 0.0 2.7 3 0 0 3 3 3 0 Ferrous iron transport protein B AAA_22 PF13401.6 ETO14273.1 - 0.068 13.5 0.1 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO14273.1 - 0.11 12.9 0.0 0.18 12.1 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO14273.1 - 0.11 13.0 1.2 0.47 11.0 0.9 2.2 1 1 0 2 2 2 0 ABC transporter AAA_29 PF13555.6 ETO14273.1 - 0.14 11.9 0.0 0.29 10.9 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Hpr_kinase_C PF07475.12 ETO14273.1 - 0.28 10.7 3.0 6.2 6.3 0.0 3.6 3 1 1 4 4 4 0 HPr Serine kinase C-terminal domain Abhydrolase_6 PF12697.7 ETO14275.1 - 8.8e-12 46.1 0.0 1.1e-11 45.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ETO14275.1 - 0.00014 21.6 0.0 0.0002 21.1 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ETO14275.1 - 0.0011 18.4 0.0 0.0016 17.7 0.0 1.3 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Thioesterase PF00975.20 ETO14275.1 - 0.0017 18.5 0.0 0.0026 17.9 0.0 1.2 1 0 0 1 1 1 1 Thioesterase domain Lipase_3 PF01764.25 ETO14275.1 - 0.0038 17.1 0.0 0.0071 16.2 0.0 1.5 1 0 0 1 1 1 1 Lipase (class 3) Chlorophyllase2 PF12740.7 ETO14275.1 - 0.0043 16.0 0.0 0.0058 15.6 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme Abhydrolase_3 PF07859.13 ETO14275.1 - 0.026 14.4 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold NodS PF05401.11 ETO14275.1 - 0.045 13.4 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) DUF915 PF06028.11 ETO14275.1 - 0.087 12.1 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) DUF2974 PF11187.8 ETO14275.1 - 0.11 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Ser_hydrolase PF06821.13 ETO14275.1 - 0.11 12.4 0.0 0.17 11.7 0.0 1.3 1 0 0 1 1 1 0 Serine hydrolase LTD PF00932.19 ETO14276.1 - 0.0074 16.6 0.0 0.011 16.1 0.0 1.3 1 0 0 1 1 1 1 Lamin Tail Domain PPR_2 PF13041.6 ETO14277.1 - 7.5e-09 35.7 6.5 0.0065 16.6 0.9 5.4 5 0 0 5 5 5 3 PPR repeat family PPR PF01535.20 ETO14277.1 - 2.3e-05 24.3 9.3 6.9 7.2 0.1 6.4 6 0 0 6 6 6 3 PPR repeat PPR_3 PF13812.6 ETO14277.1 - 0.00024 21.1 14.3 0.017 15.2 0.8 5.5 6 2 0 6 6 6 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO14277.1 - 0.004 16.8 10.9 1 9.1 0.0 6.0 7 0 0 7 7 7 2 PPR repeat CCM2_C PF16545.5 ETO14277.1 - 0.13 12.8 0.9 0.41 11.2 0.2 2.2 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology Actin PF00022.19 ETO14278.1 - 3.9e-81 272.7 0.0 1.5e-80 270.8 0.0 1.7 1 1 0 1 1 1 1 Actin ATP-grasp_2 PF08442.10 ETO14279.1 - 3.2e-58 196.6 5.4 3.4e-42 144.3 0.0 3.3 2 1 1 3 3 3 3 ATP-grasp domain Ligase_CoA PF00549.19 ETO14279.1 - 1.3e-26 93.2 1.0 2.4e-26 92.4 1.0 1.4 1 0 0 1 1 1 1 CoA-ligase ATP-grasp_5 PF13549.6 ETO14279.1 - 0.099 12.1 0.4 0.49 9.8 0.0 2.2 2 1 0 2 2 2 0 ATP-grasp domain zf-C3H2C3 PF17122.5 ETO14280.1 - 0.00082 19.4 3.4 0.0076 16.3 0.7 2.4 2 0 0 2 2 2 1 Zinc-finger zf-RING_5 PF14634.6 ETO14280.1 - 0.0031 17.4 2.4 0.013 15.4 2.5 2.0 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO14280.1 - 0.0098 15.9 1.2 0.13 12.3 0.1 2.6 2 1 0 2 2 2 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO14280.1 - 0.01 16.2 0.7 0.01 16.2 0.7 2.3 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO14280.1 - 0.012 15.4 1.4 0.012 15.4 1.4 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO14280.1 - 0.013 15.4 1.4 0.11 12.4 1.9 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO14280.1 - 0.027 14.7 2.0 0.073 13.4 2.0 1.8 1 0 0 1 1 1 0 RING-H2 zinc finger domain Prok-RING_4 PF14447.6 ETO14280.1 - 1.2 9.1 8.1 0.069 13.0 1.1 2.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 4 Helicase_C PF00271.31 ETO14281.1 - 4.7e-18 65.6 0.0 1.5e-17 63.9 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ETO14281.1 - 0.00076 19.7 3.8 0.016 15.4 0.3 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF4217) PAD_N PF08526.10 ETO14281.1 - 0.04 14.3 0.0 0.072 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) N-terminal domain ERCC3_RAD25_C PF16203.5 ETO14281.1 - 0.082 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 ERCC3/RAD25/XPB C-terminal helicase Glyco_transf_22 PF03901.17 ETO14282.1 - 1.2e-76 258.7 28.9 1.5e-76 258.3 28.9 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Phospholip_B PF04916.13 ETO14283.1 - 2.5e-115 386.1 4.4 2.8e-115 385.9 4.4 1.0 1 0 0 1 1 1 1 Phospholipase B CDC45 PF02724.14 ETO14284.1 - 0.0097 14.3 2.1 0.01 14.2 2.1 1.1 1 0 0 1 1 1 1 CDC45-like protein Vfa1 PF08432.10 ETO14284.1 - 0.015 15.6 8.1 0.016 15.5 8.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RRN3 PF05327.11 ETO14284.1 - 0.025 13.2 1.6 0.026 13.1 1.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO14284.1 - 0.065 11.3 4.8 0.074 11.2 4.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ETO14284.1 - 0.64 9.7 3.4 0.77 9.4 3.4 1.3 1 0 0 1 1 1 0 FAM176 family RPN2_C PF18004.1 ETO14284.1 - 0.78 9.6 10.1 1 9.3 10.1 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2956 PF11169.8 ETO14284.1 - 2.1 8.6 9.8 0.53 10.5 6.8 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) RNA_pol_Rpc4 PF05132.14 ETO14284.1 - 6.1 7.3 7.3 8.5 6.8 7.3 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 SPRY PF00622.28 ETO14285.1 - 6.4e-12 45.7 0.1 1.7e-11 44.3 0.1 1.8 1 1 0 1 1 1 1 SPRY domain zf-RanBP PF00641.18 ETO14285.1 - 2.4e-06 26.8 3.2 6.2e-06 25.4 3.2 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO14285.1 - 0.18 11.2 4.5 1.5 8.3 4.5 2.4 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DCB PF16213.5 ETO14285.1 - 0.95 9.1 5.3 0.18 11.4 0.1 2.5 3 0 0 3 3 3 0 Dimerisation and cyclophilin-binding domain of Mon2 FCH PF00611.23 ETO14286.1 - 0.00024 21.3 7.3 0.00036 20.7 1.5 2.7 2 1 0 2 2 2 1 Fes/CIP4, and EFC/F-BAR homology domain MADF_DNA_bdg PF10545.9 ETO14286.1 - 1.6 9.1 11.2 1.8 8.9 2.1 2.7 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like HAD_2 PF13419.6 ETO14286.1 - 3.2 7.8 11.2 0.3 11.2 2.6 2.3 2 0 0 2 2 2 0 Haloacid dehalogenase-like hydrolase Rsc14 PF08586.10 ETO14286.1 - 9.9 7.0 9.8 13 6.6 1.6 2.4 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Glyco_transf_10 PF00852.19 ETO14288.1 - 3.8e-39 134.2 1.2 6.9e-39 133.4 1.2 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Glyco_tran_10_N PF17039.5 ETO14288.1 - 4.7e-07 30.2 0.0 7.9e-06 26.3 0.0 2.7 3 0 0 3 3 3 1 Fucosyltransferase, N-terminal GYF_2 PF14237.6 ETO14289.1 - 6.1e-05 22.7 0.3 0.00012 21.8 0.3 1.5 1 0 0 1 1 1 1 GYF domain 2 Kelch_1 PF01344.25 ETO14289.1 - 0.0062 16.1 1.9 0.019 14.5 0.2 2.5 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO14289.1 - 0.18 11.8 0.7 0.34 11.0 0.7 1.4 1 0 0 1 1 1 0 Galactose oxidase, central domain SRP54 PF00448.22 ETO14290.1 - 3e-75 252.2 0.4 5.7e-75 251.3 0.4 1.5 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain SRP_SPB PF02978.19 ETO14290.1 - 2.7e-24 85.7 0.8 2.7e-24 85.7 0.8 3.1 2 1 1 3 3 1 1 Signal peptide binding domain SRP54_N PF02881.19 ETO14290.1 - 3.2e-12 46.5 1.8 3.2e-12 46.5 1.8 2.2 2 0 0 2 2 2 1 SRP54-type protein, helical bundle domain CbiA PF01656.23 ETO14290.1 - 2.6e-06 27.5 0.7 0.0002 21.4 0.0 2.7 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain cobW PF02492.19 ETO14290.1 - 1.4e-05 24.8 5.7 0.00023 20.8 3.8 3.0 2 1 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain MeaB PF03308.16 ETO14290.1 - 0.00022 20.3 0.1 0.00052 19.1 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_17 PF13207.6 ETO14290.1 - 0.0011 19.4 0.1 0.0011 19.4 0.1 3.0 3 1 0 3 3 2 1 AAA domain AAA_16 PF13191.6 ETO14290.1 - 0.0014 19.0 0.0 0.022 15.2 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain SRPRB PF09439.10 ETO14290.1 - 0.0045 16.5 0.8 2.4 7.6 0.0 2.5 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 ETO14290.1 - 0.0066 16.6 0.0 0.016 15.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Dynamin_N PF00350.23 ETO14290.1 - 0.0084 16.2 0.4 0.05 13.7 0.0 2.3 2 0 0 2 2 2 1 Dynamin family MobB PF03205.14 ETO14290.1 - 0.01 15.7 0.3 0.044 13.7 0.0 2.1 1 1 1 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B CLP1_P PF16575.5 ETO14290.1 - 0.012 15.4 0.6 0.74 9.6 0.1 2.5 1 1 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop MMR_HSR1 PF01926.23 ETO14290.1 - 0.022 14.9 1.4 0.12 12.4 0.5 2.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 ETO14290.1 - 0.027 14.2 0.0 0.066 12.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain 6PF2K PF01591.18 ETO14290.1 - 0.032 13.5 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 0 6-phosphofructo-2-kinase PduV-EutP PF10662.9 ETO14290.1 - 0.039 13.7 0.5 1.9 8.2 0.2 2.6 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_31 PF13614.6 ETO14290.1 - 0.049 13.6 0.0 0.2 11.5 0.0 2.0 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ETO14290.1 - 0.07 12.9 0.1 0.2 11.4 0.1 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 ETO14290.1 - 0.075 13.6 0.7 0.24 11.9 0.2 2.3 2 1 0 2 2 1 0 AAA domain APS_kinase PF01583.20 ETO14290.1 - 0.087 12.7 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 Adenylylsulphate kinase HAD_2 PF13419.6 ETO14290.1 - 0.21 11.7 4.4 7.3 6.6 0.1 3.3 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase AAA_22 PF13401.6 ETO14290.1 - 0.24 11.7 2.6 0.52 10.6 1.0 2.5 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ETO14290.1 - 0.49 10.8 3.1 3.8 7.9 0.7 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ETO14290.1 - 2.7 7.9 7.6 32 4.4 4.8 2.9 2 1 0 2 2 2 0 NTPase Plasmodium_Vir PF05795.11 ETO14291.1 - 0.0061 16.0 0.6 0.0072 15.8 0.6 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein CPBP PF02517.16 ETO14292.1 - 0.67 10.4 4.3 8.7 6.8 0.6 2.3 2 0 0 2 2 2 0 CPBP intramembrane metalloprotease PAS_11 PF14598.6 ETO14294.1 - 0.044 13.9 0.5 0.33 11.1 0.2 2.3 2 0 0 2 2 2 0 PAS domain Myosin_head PF00063.21 ETO14295.1 - 1.8e-149 499.1 9.2 3e-120 402.5 4.9 2.4 2 0 0 2 2 2 2 Myosin head (motor domain) MyTH4 PF00784.17 ETO14295.1 - 2.4e-26 92.3 0.0 6.6e-26 90.9 0.0 1.8 1 0 0 1 1 1 1 MyTH4 domain BIR PF00653.21 ETO14296.1 - 0.67 10.7 7.5 7.8 7.2 0.9 3.2 2 1 1 3 3 3 0 Inhibitor of Apoptosis domain Metallophos_2 PF12850.7 ETO14297.1 - 4.5e-09 36.7 0.1 5.1e-09 36.5 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ETO14297.1 - 2.5e-08 34.7 0.6 2.9e-08 34.4 0.6 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Epimerase_2 PF02350.19 ETO14297.1 - 0.022 13.6 0.1 0.027 13.3 0.1 1.1 1 0 0 1 1 1 0 UDP-N-acetylglucosamine 2-epimerase TMEM135_C_rich PF15982.5 ETO14299.1 - 0.034 14.7 2.4 0.047 14.3 0.3 2.2 2 1 1 3 3 3 0 N-terminal cysteine-rich region of Transmembrane protein 135 WD40 PF00400.32 ETO14301.1 - 1.5e-66 218.7 20.3 6.7e-10 39.4 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14301.1 - 1.9e-22 79.4 0.2 0.00044 20.5 0.0 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14301.1 - 2.5e-21 76.0 3.4 0.056 12.4 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO14301.1 - 4.5e-07 29.6 5.0 3.9 7.5 0.0 6.2 7 0 0 7 7 6 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO14301.1 - 1.9e-06 26.8 5.5 2.7 6.5 0.0 5.7 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETO14301.1 - 3.9e-05 23.2 12.8 2.3 8.0 0.4 6.7 7 0 0 7 7 7 2 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETO14301.1 - 4.5e-05 22.2 0.2 0.28 9.7 0.0 3.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO14301.1 - 0.00019 20.9 0.1 0.34 10.2 0.2 2.4 1 1 1 2 2 2 2 WD40-like domain DUF5570 PF17731.1 ETO14301.1 - 0.00025 21.1 3.0 13 5.8 0.0 4.6 1 1 3 5 5 5 1 Family of unknown function (DUF5570) Methyltransf_3 PF01596.17 ETO14301.1 - 0.0021 17.3 0.0 2.6 7.1 0.0 3.8 2 1 2 4 4 4 1 O-methyltransferase DUF727 PF05303.12 ETO14301.1 - 0.0027 17.7 0.1 10 6.2 0.0 4.2 2 2 2 4 4 4 1 Protein of unknown function (DUF727) AcetylCoA_hyd_C PF13336.6 ETO14301.1 - 0.076 12.9 0.5 3.5 7.5 0.0 3.7 3 2 2 5 5 5 0 Acetyl-CoA hydrolase/transferase C-terminal domain Mid2 PF04478.12 ETO14301.1 - 0.11 12.3 0.1 6.3 6.6 0.0 3.2 2 1 1 3 3 3 0 Mid2 like cell wall stress sensor Ins_P5_2-kin PF06090.12 ETO14302.1 - 1.1e-58 199.2 12.6 2.1e-58 198.3 12.6 1.4 1 1 0 1 1 1 1 Inositol-pentakisphosphate 2-kinase Sec20 PF03908.13 ETO14302.1 - 0.1 12.5 2.1 0.3 11.0 1.6 2.0 2 0 0 2 2 2 0 Sec20 G-patch_2 PF12656.7 ETO14303.1 - 0.0069 16.4 0.5 0.013 15.6 0.1 1.7 1 1 1 2 2 2 1 G-patch domain G-patch PF01585.23 ETO14303.1 - 0.043 13.7 0.1 0.074 13.0 0.1 1.4 1 0 0 1 1 1 0 G-patch domain DUF4606 PF15379.6 ETO14303.1 - 0.18 12.1 3.4 0.37 11.0 2.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4606) DHR10 PF18595.1 ETO14305.1 - 0.0042 17.1 14.6 0.0042 17.1 14.6 10.3 7 4 3 10 10 10 1 Designed helical repeat protein 10 domain DUF4330 PF14221.6 ETO14305.1 - 0.042 14.1 1.3 0.45 10.7 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4330) S1FA PF04689.13 ETO14305.1 - 0.05 13.8 2.8 10 6.3 0.0 3.2 2 0 0 2 2 2 0 DNA binding protein S1FA Pkinase PF00069.25 ETO14306.1 - 4e-40 137.8 0.0 4.8e-40 137.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14306.1 - 1.1e-18 67.5 0.0 1.2e-18 67.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO14306.1 - 0.00039 19.8 0.0 0.00066 19.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO14306.1 - 0.00076 18.5 0.1 0.001 18.1 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ETO14306.1 - 0.011 15.1 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO14306.1 - 0.088 12.7 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family AMP-binding PF00501.28 ETO14308.1 - 9e-47 159.6 0.1 1.2e-46 159.2 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme WD40 PF00400.32 ETO14309.1 - 0.0017 19.1 0.3 0.015 16.1 0.3 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat TIP49_C PF17856.1 ETO14309.1 - 0.093 12.9 0.3 0.39 10.9 0.1 1.9 2 0 0 2 2 2 0 TIP49 AAA-lid domain TPR_1 PF00515.28 ETO14310.1 - 4.9e-08 32.5 1.1 0.011 15.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14310.1 - 9e-08 31.8 0.2 0.0012 18.9 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO14310.1 - 9.9e-07 29.2 0.0 2e-06 28.2 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14310.1 - 1.8e-06 27.6 1.5 0.0077 16.3 0.3 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO14310.1 - 4.1e-05 23.8 3.7 0.00053 20.2 1.4 2.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO14310.1 - 0.00012 22.6 0.8 0.0047 17.6 0.2 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14310.1 - 0.0011 18.7 0.6 0.027 14.2 0.0 2.4 2 0 0 2 2 2 1 TPR repeat TPR_10 PF13374.6 ETO14310.1 - 0.0013 18.5 0.7 1.6 8.7 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14310.1 - 0.0019 18.4 1.0 0.005 17.0 0.9 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETO14310.1 - 0.0039 17.5 0.1 0.011 16.0 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14310.1 - 0.0066 17.1 0.1 0.47 11.1 0.1 2.3 1 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14310.1 - 0.013 15.8 0.4 0.23 11.9 0.3 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Coatomer_E PF04733.14 ETO14310.1 - 0.027 13.9 0.8 0.33 10.3 0.7 2.2 1 1 1 2 2 2 0 Coatomer epsilon subunit TPR_6 PF13174.6 ETO14310.1 - 0.041 14.5 0.3 5.1 8.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 ETO14310.1 - 0.055 12.9 0.6 0.079 12.4 0.6 1.2 1 0 0 1 1 1 0 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO14310.1 - 0.064 13.3 0.6 3 8.0 0.2 2.3 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain IBR PF01485.21 ETO14312.1 - 0.045 14.0 1.7 0.064 13.5 0.3 1.9 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain Serinc PF03348.15 ETO14313.1 - 0.062 12.2 2.0 0.07 12.0 2.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) PI3K_1B_p101 PF10486.9 ETO14314.1 - 0.051 11.4 2.5 0.07 10.9 2.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PBP1_TM PF14812.6 ETO14314.1 - 4.7 7.6 11.6 0.46 10.9 5.1 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_S6e PF01092.19 ETO14316.1 - 5.7e-47 158.8 0.2 5.7e-47 158.8 0.2 1.8 2 1 0 2 2 2 1 Ribosomal protein S6e PBP_sp32 PF07222.12 ETO14316.1 - 1.8 8.0 9.4 2.7 7.4 9.4 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Sec7 PF01369.20 ETO14318.1 - 1.4e-56 191.1 3.1 3.3e-56 189.9 3.1 1.7 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ETO14318.1 - 6.1e-33 114.0 4.6 1.5e-32 112.7 3.1 2.6 1 1 1 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal zf-XS PF03470.14 ETO14319.1 - 0.15 12.3 3.1 0.64 10.3 3.1 2.1 1 0 0 1 1 1 0 XS zinc finger domain zf-C2H2_8 PF15909.5 ETO14320.1 - 0.035 14.4 0.7 0.064 13.6 0.6 1.5 1 1 0 1 1 1 0 C2H2-type zinc ribbon zf-C2H2_4 PF13894.6 ETO14320.1 - 0.057 14.3 2.7 0.08 13.8 0.2 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO14320.1 - 0.096 13.2 2.5 0.11 13.0 0.2 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type FOXP-CC PF16159.5 ETO14320.1 - 0.14 12.8 2.0 0.32 11.6 0.1 2.2 1 1 1 2 2 2 0 FOXP coiled-coil domain zf-Di19 PF05605.12 ETO14320.1 - 0.62 10.4 3.6 0.83 10.0 0.1 2.4 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Mso1_Sec1_bdg PF14475.6 ETO14320.1 - 0.67 9.6 0.0 0.67 9.6 0.0 2.2 3 0 0 3 3 3 0 Sec1-binding region of Mso1 Herpes_UL92 PF03048.14 ETO14323.1 - 0.055 13.2 0.0 0.076 12.8 0.0 1.2 1 0 0 1 1 1 0 UL92 family DUF3336 PF11815.8 ETO14324.1 - 7e-12 45.2 4.3 9.8e-12 44.8 4.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) DUF3336 PF11815.8 ETO14325.1 - 2e-24 85.9 0.3 2.4e-23 82.4 0.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF3336) Patatin PF01734.22 ETO14325.1 - 5.1e-21 75.8 0.0 8.5e-21 75.1 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase SNAPc19 PF15497.6 ETO14325.1 - 0.01 16.3 0.3 0.022 15.2 0.3 1.5 1 0 0 1 1 1 1 snRNA-activating protein complex subunit 19, SNAPc subunit 19 Myc_N PF01056.18 ETO14326.1 - 0.057 13.3 0.1 0.057 13.3 0.1 1.1 1 0 0 1 1 1 0 Myc amino-terminal region SR-25 PF10500.9 ETO14327.1 - 0.0059 16.2 6.6 0.01 15.4 6.6 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Ubiquitin_4 PF18036.1 ETO14327.1 - 0.041 13.9 3.5 0.04 14.0 1.7 1.9 2 0 0 2 2 2 0 Ubiquitin-like domain Cob_adeno_trans PF01923.18 ETO14327.1 - 0.4 10.8 2.2 9.8 6.3 0.1 2.1 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Spc29 PF17082.5 ETO14327.1 - 0.86 9.4 6.3 0.52 10.1 3.0 1.9 1 1 0 2 2 2 0 Spindle Pole Component 29 D123 PF07065.14 ETO14328.1 - 4.8e-18 65.4 0.2 4.8e-18 65.4 0.2 2.7 3 0 0 3 3 3 2 D123 R2K_2 PF18299.1 ETO14328.1 - 2.6e-06 27.4 0.0 5.9e-06 26.2 0.0 1.6 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ETO14328.1 - 3.5e-06 27.2 0.0 1.2e-05 25.4 0.0 1.8 2 0 0 2 2 2 1 ATP-grasp domain, R2K clade family 3 OAF PF14941.6 ETO14328.1 - 0.00031 20.3 0.0 0.00084 18.9 0.0 1.7 1 0 0 1 1 1 1 Transcriptional regulator, Out at first DUF2207 PF09972.9 ETO14328.1 - 0.094 11.5 2.5 0.1 11.3 2.5 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Spt20 PF12090.8 ETO14332.1 - 4.3e-05 23.2 30.2 5.3e-05 23.0 30.2 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 ETO14332.1 - 0.00076 19.6 23.0 0.00077 19.6 23.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit eIF-3_zeta PF05091.12 ETO14332.1 - 0.0045 16.0 13.8 0.0048 15.9 13.8 1.1 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DDHD PF02862.17 ETO14332.1 - 0.0061 16.7 9.6 0.0072 16.5 9.6 1.1 1 0 0 1 1 1 1 DDHD domain Pex26 PF07163.12 ETO14332.1 - 0.0061 15.9 9.4 0.008 15.5 9.4 1.2 1 0 0 1 1 1 1 Pex26 protein Pex14_N PF04695.13 ETO14332.1 - 0.0069 17.1 13.5 0.0097 16.6 13.5 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region SLC12 PF03522.15 ETO14332.1 - 0.011 14.8 11.1 0.012 14.7 11.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 ETO14332.1 - 0.056 12.4 3.1 0.055 12.4 3.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Het-C PF07217.11 ETO14332.1 - 0.074 11.6 8.0 0.083 11.4 8.0 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C CSG2 PF16965.5 ETO14332.1 - 0.074 12.0 4.6 0.079 11.9 4.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4407 PF14362.6 ETO14332.1 - 0.096 12.0 12.3 0.11 11.8 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CPSF100_C PF13299.6 ETO14332.1 - 0.11 12.7 7.2 0.13 12.4 7.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4834 PF16118.5 ETO14332.1 - 0.11 13.4 14.4 0.22 12.5 14.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SprA-related PF12118.8 ETO14332.1 - 0.12 11.4 23.2 0.15 11.2 23.2 1.0 1 0 0 1 1 1 0 SprA-related family FHIPEP PF00771.20 ETO14332.1 - 0.15 10.5 4.7 0.17 10.3 4.7 1.1 1 0 0 1 1 1 0 FHIPEP family dsRBD2 PF17842.1 ETO14332.1 - 0.15 12.2 8.8 0.23 11.6 8.8 1.2 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Presenilin PF01080.17 ETO14332.1 - 0.19 10.5 12.5 0.22 10.2 12.5 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO14332.1 - 0.23 10.2 6.3 0.21 10.4 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SpoIIP PF07454.11 ETO14332.1 - 0.33 10.4 14.3 0.4 10.1 14.3 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Connexin PF00029.19 ETO14332.1 - 0.36 10.6 10.6 0.61 9.8 10.6 1.4 1 0 0 1 1 1 0 Connexin Neur_chan_memb PF02932.16 ETO14332.1 - 0.36 10.8 10.4 0.43 10.6 10.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4175 PF13779.6 ETO14332.1 - 0.4 8.5 23.6 0.46 8.3 23.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) EOS1 PF12326.8 ETO14332.1 - 0.46 10.4 6.6 0.6 10.0 6.6 1.2 1 0 0 1 1 1 0 N-glycosylation protein TERB2 PF15101.6 ETO14332.1 - 0.56 10.2 17.3 0.73 9.8 17.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Band_3_cyto PF07565.13 ETO14332.1 - 0.6 9.9 14.0 0.81 9.4 14.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Ctr PF04145.15 ETO14332.1 - 0.65 10.6 9.1 0.73 10.5 9.1 1.3 1 1 0 1 1 1 0 Ctr copper transporter family EIIBC-GUT_N PF03612.14 ETO14332.1 - 0.91 9.2 11.0 2.7 7.7 11.6 1.4 2 0 0 2 2 1 0 Sorbitol phosphotransferase enzyme II N-terminus UPF0560 PF10577.9 ETO14332.1 - 0.98 7.8 17.3 1.2 7.6 17.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PRC2_HTH_1 PF18118.1 ETO14332.1 - 1 10.2 9.3 1.8 9.4 9.3 1.4 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain CLN3 PF02487.17 ETO14332.1 - 1.1 8.3 9.8 1.3 8.0 9.8 1.1 1 0 0 1 1 1 0 CLN3 protein DUF2722 PF10846.8 ETO14332.1 - 1.3 7.9 32.8 1.8 7.4 32.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Coilin_N PF15862.5 ETO14332.1 - 1.3 8.8 13.6 2.2 8.1 13.6 1.3 1 0 0 1 1 1 0 Coilin N-terminus CobT PF06213.12 ETO14332.1 - 1.3 8.3 15.1 1.8 7.9 15.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MMR1 PF08505.10 ETO14332.1 - 1.4 9.2 16.7 1.7 8.9 16.7 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Kei1 PF08552.11 ETO14332.1 - 1.5 8.6 5.5 2 8.3 5.5 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SUIM_assoc PF16619.5 ETO14332.1 - 1.6 8.9 38.8 1.8e+04 -8.0 38.9 2.7 1 1 0 1 1 0 0 Unstructured region C-term to UIM in Ataxin3 Ureide_permease PF07168.11 ETO14332.1 - 2 7.1 8.1 2.7 6.7 8.1 1.1 1 0 0 1 1 1 0 Ureide permease FAM176 PF14851.6 ETO14332.1 - 2.3 7.9 8.3 4.3 7.0 8.3 1.4 1 0 0 1 1 1 0 FAM176 family Folate_carrier PF01770.18 ETO14332.1 - 3.2 6.4 8.5 4.3 6.0 8.5 1.2 1 0 0 1 1 1 0 Reduced folate carrier HCO3_cotransp PF00955.21 ETO14332.1 - 3.7 6.2 8.4 5.1 5.8 8.4 1.2 1 0 0 1 1 1 0 HCO3- transporter family MTP18 PF10558.9 ETO14332.1 - 3.8 7.4 7.4 6.3 6.7 7.4 1.3 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Androgen_recep PF02166.16 ETO14332.1 - 4.1 6.1 26.6 5.3 5.8 26.6 1.1 1 0 0 1 1 1 0 Androgen receptor PepSY_TM PF03929.16 ETO14332.1 - 4.1 7.0 6.5 5.5 6.6 6.5 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Peptidase_S49_N PF08496.10 ETO14332.1 - 4.8 7.2 11.1 7.1 6.7 11.1 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal G0-G1_switch_2 PF15103.6 ETO14332.1 - 5.1 7.6 9.5 8.3 6.9 9.5 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 Roughex PF06020.11 ETO14332.1 - 5.2 6.1 12.7 7.4 5.6 12.7 1.3 1 0 0 1 1 1 0 Drosophila roughex protein AIF_C PF14721.6 ETO14332.1 - 6.5 7.1 10.8 11 6.4 10.8 1.4 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF1980 PF09323.10 ETO14332.1 - 7.6 6.4 11.7 11 5.9 11.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Otopetrin PF03189.13 ETO14332.1 - 7.7 5.2 15.7 11 4.7 15.7 1.1 1 0 0 1 1 1 0 Otopetrin EPL1 PF10513.9 ETO14332.1 - 8.8 6.7 17.6 13 6.1 17.6 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Zip PF02535.22 ETO14332.1 - 9.7 5.3 6.5 11 5.1 6.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter LMBR1 PF04791.16 ETO14332.1 - 9.8 4.9 9.7 11 4.8 9.7 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein BRCT PF00533.26 ETO14333.1 - 6.2e-09 36.1 0.3 1.5e-08 34.9 0.1 1.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ETO14333.1 - 1.8e-08 34.2 0.2 1.8e-08 34.2 0.2 2.0 2 1 0 2 2 2 1 twin BRCT domain LIG3_BRCT PF16759.5 ETO14333.1 - 0.00013 22.2 0.3 0.00026 21.2 0.2 1.5 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 ETO14333.1 - 0.021 15.2 0.0 0.043 14.2 0.0 1.6 1 0 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ETO14333.1 - 0.025 14.4 0.1 0.047 13.6 0.0 1.5 1 1 0 1 1 1 0 Regulator of Ty1 transposition protein 107 BRCT domain Epimerase PF01370.21 ETO14333.1 - 0.035 13.6 0.1 0.042 13.3 0.1 1.1 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family BRCT_3 PF18428.1 ETO14333.1 - 0.057 13.5 0.0 0.084 12.9 0.0 1.3 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain NIF PF03031.18 ETO14334.1 - 4.5e-15 55.8 0.1 8.4e-15 54.9 0.1 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase TPR_12 PF13424.6 ETO14335.1 - 7.6e-32 109.4 0.7 1.6e-11 44.4 0.0 5.2 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14335.1 - 1.7e-21 75.4 0.0 0.00026 20.7 0.1 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14335.1 - 1.4e-19 69.0 25.4 2.7e-05 23.8 0.6 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14335.1 - 5.9e-17 60.4 26.4 0.00023 21.1 0.7 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14335.1 - 1.1e-15 56.4 1.0 0.013 15.5 0.0 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14335.1 - 2.4e-14 52.2 18.5 0.0012 18.8 0.3 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14335.1 - 0.00015 21.3 13.5 0.0045 16.6 0.6 4.6 4 0 0 4 4 4 2 TPR repeat TPR_6 PF13174.6 ETO14335.1 - 0.00075 20.0 2.7 5.4 7.9 0.0 4.4 4 1 0 4 4 4 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO14335.1 - 0.00088 19.1 1.9 0.00088 19.1 1.9 2.5 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) ANAPC3 PF12895.7 ETO14335.1 - 0.0058 16.8 4.0 0.031 14.5 0.1 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO14335.1 - 0.012 15.6 16.6 0.014 15.3 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ETO14335.1 - 0.015 15.4 18.4 0.71 10.0 0.5 5.3 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO14335.1 - 0.022 14.2 1.0 0.87 9.1 0.0 3.5 4 0 0 4 4 4 0 SHNi-TPR Kelch_2 PF07646.15 ETO14335.1 - 0.25 11.4 1.3 8.3 6.6 0.1 2.5 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO14336.1 - 8e-70 229.0 19.8 1.6e-11 44.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14336.1 - 9.7e-26 89.9 6.1 0.0011 19.2 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14336.1 - 1.5e-12 47.1 2.7 0.7 8.8 0.0 6.5 2 1 5 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14336.1 - 1.9e-12 47.1 3.7 0.0049 16.2 0.0 4.7 1 1 4 5 5 5 5 WD40-like domain Cytochrom_D1 PF02239.16 ETO14336.1 - 1.1e-07 30.8 1.2 0.0026 16.3 0.1 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO14336.1 - 0.0001 21.2 10.3 0.034 12.9 0.8 4.3 1 1 3 4 4 4 3 Nup133 N terminal like DUF1513 PF07433.11 ETO14336.1 - 0.00044 19.4 0.0 0.24 10.4 0.0 3.0 1 1 3 4 4 4 2 Protein of unknown function (DUF1513) SGL PF08450.12 ETO14336.1 - 0.00052 19.7 0.4 0.0012 18.4 0.4 1.8 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 ETO14336.1 - 0.0058 16.5 3.1 34 4.5 0.0 5.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO14336.1 - 0.034 14.1 0.0 18 5.5 0.0 4.3 4 0 0 4 4 4 0 PQQ enzyme repeat LMP PF04778.12 ETO14336.1 - 0.035 14.0 2.0 0.053 13.4 0.6 2.1 2 1 0 2 2 2 0 LMP repeated region Proteasome_A_N PF10584.9 ETO14336.1 - 0.23 11.2 0.1 14 5.5 0.0 3.1 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO14337.1 - 3.9e-40 135.1 18.2 2.9e-07 31.1 1.4 7.8 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO14337.1 - 2.5e-11 43.0 9.8 0.0034 16.1 0.2 4.7 1 1 4 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14337.1 - 8.2e-11 42.1 5.9 0.25 11.7 0.1 6.1 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Jnk-SapK_ap_N PF09744.9 ETO14337.1 - 0.12 12.6 14.8 0.24 11.6 14.8 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF4979 PF16351.5 ETO14337.1 - 0.16 12.2 2.0 8.4 6.6 0.0 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4979) Atg14 PF10186.9 ETO14337.1 - 0.81 8.7 12.0 0.74 8.8 9.5 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 ETO14337.1 - 0.89 8.8 2.7 1.3 8.3 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Geminin PF07412.12 ETO14337.1 - 8.7 6.0 20.7 1.2 8.9 2.7 2.3 2 0 0 2 2 2 0 Geminin G-gamma PF00631.22 ETO14338.1 - 0.0088 16.0 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 GGL domain tRNA-synt_1g PF09334.11 ETO14339.1 - 0.00052 18.9 1.7 0.0014 17.5 1.7 1.7 1 0 0 1 1 1 1 tRNA synthetases class I (M) FSA_C PF10479.9 ETO14340.1 - 0.0002 19.7 1.0 0.0002 19.7 1.0 1.1 1 0 0 1 1 1 1 Fragile site-associated protein C-terminus Med13_C PF06333.12 ETO14340.1 - 0.0032 16.8 3.0 0.0033 16.7 3.0 1.2 1 0 0 1 1 1 1 Mediator complex subunit 13 C-terminal domain Dicty_REP PF05086.12 ETO14340.1 - 0.023 12.7 10.4 0.0032 15.5 6.7 1.5 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 ETO14340.1 - 0.038 14.0 25.0 0.058 13.4 25.0 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein AJAP1_PANP_C PF15298.6 ETO14340.1 - 0.11 12.7 13.5 0.19 12.0 13.5 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF2990 PF11693.8 ETO14340.1 - 0.12 12.6 0.1 0.76 10.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2990) MGC-24 PF05283.11 ETO14340.1 - 3.7 8.0 12.5 5.9 7.3 12.5 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SSP160 PF06933.11 ETO14340.1 - 6.7 4.8 22.6 10 4.2 22.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 mTERF PF02536.14 ETO14342.1 - 0.012 14.5 0.0 0.015 14.2 0.0 1.3 1 0 0 1 1 1 0 mTERF mTERF PF02536.14 ETO14343.1 - 0.0015 17.5 0.1 0.14 11.1 0.0 2.6 2 1 0 2 2 2 2 mTERF N6_N4_Mtase PF01555.18 ETO14346.1 - 0.003 17.3 2.2 0.004 16.9 2.2 1.1 1 0 0 1 1 1 1 DNA methylase MKT1_C PF12246.8 ETO14346.1 - 0.018 14.3 0.6 0.026 13.8 0.2 1.4 2 0 0 2 2 2 0 Temperature dependent protein affecting M2 dsRNA replication Stn1 PF10451.9 ETO14346.1 - 0.031 13.3 3.5 0.037 13.0 3.5 1.1 1 0 0 1 1 1 0 Telomere regulation protein Stn1 SET PF00856.28 ETO14347.1 - 0.023 15.1 0.1 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 SET domain GIT1_C PF12205.8 ETO14347.1 - 0.073 13.2 0.2 0.12 12.5 0.2 1.3 1 0 0 1 1 1 0 G protein-coupled receptor kinase-interacting protein 1 C term PEPCK_GTP PF00821.18 ETO14348.1 - 5.1e-33 114.4 1.9 1.3e-32 113.0 1.9 1.6 1 1 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain GTP_EFTU PF00009.27 ETO14349.1 - 2.2e-19 69.7 0.2 2.2e-19 69.7 0.2 2.0 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETO14349.1 - 8.1e-05 22.9 0.0 0.00026 21.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain MMR_HSR1 PF01926.23 ETO14349.1 - 0.00056 20.0 0.7 0.0028 17.7 0.7 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ETO14349.1 - 0.0041 17.5 0.1 0.03 14.7 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 Roc PF08477.13 ETO14349.1 - 0.029 14.6 0.6 0.55 10.5 0.1 2.6 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Med3 PF11593.8 ETO14349.1 - 3.5 6.7 23.8 7.4 5.6 23.8 1.5 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pheromone PF08015.11 ETO14349.1 - 3.9 8.6 10.0 20 6.3 10.0 2.3 1 1 0 1 1 1 0 Fungal mating-type pheromone PPR_2 PF13041.6 ETO14351.1 - 0.00045 20.4 0.0 1.1 9.5 0.0 3.4 3 0 0 3 3 3 2 PPR repeat family PPR_3 PF13812.6 ETO14351.1 - 0.0028 17.7 0.7 0.013 15.5 0.4 2.3 1 1 1 2 2 2 2 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO14351.1 - 0.05 13.0 0.2 0.13 11.6 0.1 1.7 2 0 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP DUF4141 PF13605.6 ETO14351.1 - 0.063 12.5 0.0 0.12 11.6 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4141) PhetRS_B1 PF18262.1 ETO14352.1 - 0.04 14.1 1.1 0.04 14.1 1.1 3.6 1 1 2 3 3 3 0 Phe-tRNA synthetase beta subunit B1 domain TagA PF12561.8 ETO14352.1 - 0.086 13.2 0.1 0.98 9.9 0.1 2.8 1 1 0 1 1 1 0 ToxR activated gene A lipoprotein domain GlcNAc-1_reg PF18440.1 ETO14352.1 - 0.72 10.1 4.9 0.38 11.0 1.3 2.4 1 1 0 1 1 1 0 Putative GlcNAc-1 phosphotransferase regulatory domain PilJ PF13675.6 ETO14352.1 - 2.1 8.4 18.8 0.78 9.8 5.4 3.1 2 1 0 3 3 3 0 Type IV pili methyl-accepting chemotaxis transducer N-term Pyr_redox PF00070.27 ETO14352.1 - 2.7 8.6 6.1 3.6 8.2 1.7 2.6 1 1 1 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase DASH_Dam1 PF08653.10 ETO14352.1 - 3.4 7.5 14.6 0.21 11.4 3.2 3.5 3 0 0 3 3 3 0 DASH complex subunit Dam1 Clat_adaptor_s PF01217.20 ETO14353.1 - 0.034 14.1 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 Clathrin adaptor complex small chain EF-hand_7 PF13499.6 ETO14354.1 - 4.1e-12 46.4 1.0 5.9e-12 45.9 1.0 1.2 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO14354.1 - 7.3e-11 40.8 2.9 0.00014 21.1 0.2 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO14354.1 - 3.2e-09 36.0 0.8 0.00053 19.7 0.1 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO14354.1 - 1.8e-07 30.3 7.2 0.00062 19.1 0.4 2.8 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO14354.1 - 9.7e-05 22.1 1.8 0.00027 20.7 1.5 1.9 1 1 0 1 1 1 1 EF-hand domain pair Dockerin_1 PF00404.18 ETO14354.1 - 0.001 19.2 0.9 0.0018 18.4 0.9 1.4 1 0 0 1 1 1 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 ETO14354.1 - 0.063 13.6 0.1 0.13 12.5 0.1 1.5 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region DUF563 PF04577.14 ETO14355.1 - 6.7e-08 32.9 0.7 4.6e-07 30.2 0.5 2.2 1 1 1 2 2 2 1 Protein of unknown function (DUF563) SIC PF03482.13 ETO14355.1 - 0.2 11.9 1.4 2.9 8.2 0.1 2.6 2 0 0 2 2 2 0 sic protein repeat Cyclin_N PF00134.23 ETO14356.1 - 3.9e-13 49.3 6.8 5.1e-07 29.5 1.1 3.4 2 1 1 3 3 3 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO14356.1 - 5e-05 23.4 0.6 5e-05 23.4 0.6 2.6 2 2 1 3 3 3 1 Cyclin, C-terminal domain His_kinase PF06580.13 ETO14356.1 - 0.068 13.5 0.2 0.15 12.4 0.2 1.5 1 0 0 1 1 1 0 Histidine kinase TMEM144 PF07857.12 ETO14357.1 - 4.6e-47 160.6 0.5 6.9e-47 160.0 0.5 1.2 1 0 0 1 1 1 1 Transmembrane family, TMEM144 of transporters FAM176 PF14851.6 ETO14357.1 - 0.00089 18.9 0.2 0.0027 17.4 0.2 1.8 1 0 0 1 1 1 1 FAM176 family O-ag_pol_Wzy PF14296.6 ETO14357.1 - 0.025 13.3 0.8 0.057 12.1 0.8 1.6 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy NOA36 PF06524.12 ETO14357.1 - 5.8 6.2 8.5 11 5.3 8.5 1.3 1 0 0 1 1 1 0 NOA36 protein Kelch_1 PF01344.25 ETO14358.1 - 2.7e-07 30.1 0.1 2.3e-06 27.1 0.0 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO14358.1 - 2.8e-06 27.4 0.0 1.8e-05 24.9 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO14358.1 - 9.8e-06 25.7 0.2 0.00051 20.2 0.1 3.2 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO14358.1 - 0.00025 21.0 0.0 0.0052 16.8 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14358.1 - 0.033 14.2 3.8 0.041 13.9 0.0 3.2 4 1 0 4 4 4 0 Kelch motif C1_2 PF03107.16 ETO14359.1 - 0.0072 16.6 0.2 0.0072 16.6 0.2 2.4 2 0 0 2 2 2 1 C1 domain Nepo_coat_N PF03689.15 ETO14359.1 - 0.016 15.2 0.6 3.4 7.7 0.1 2.2 2 0 0 2 2 2 0 Nepovirus coat protein, N-terminal domain SAM_2 PF07647.17 ETO14360.1 - 3.4e-09 36.7 0.0 5.9e-05 23.1 0.0 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) EHD_N PF16880.5 ETO14360.1 - 8.3e-08 32.0 0.3 1.6e-07 31.1 0.3 1.5 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 ETO14360.1 - 3.2e-05 24.1 0.5 0.00015 21.8 0.0 2.2 2 0 0 2 2 2 1 Dynamin family SAM_1 PF00536.30 ETO14360.1 - 0.0013 19.1 0.0 0.0036 17.7 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO14360.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.7 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain AAA_28 PF13521.6 ETO14360.1 - 0.13 12.4 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain CLZ PF16526.5 ETO14361.1 - 0.017 15.5 4.3 0.017 15.5 4.3 4.9 1 1 4 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels APC_N_CC PF16689.5 ETO14361.1 - 0.02 15.0 1.3 0.02 15.0 1.3 4.0 5 0 0 5 5 5 0 Coiled-coil N-terminus of APC, dimerisation domain TRAF_BIRC3_bd PF16673.5 ETO14361.1 - 0.24 11.2 10.2 1.3 8.9 1.3 3.5 2 1 0 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain Csm1_N PF18504.1 ETO14361.1 - 1.8 9.0 33.2 0.57 10.6 0.3 5.8 2 2 3 5 5 5 0 Csm1 N-terminal domain UPF0242 PF06785.11 ETO14361.1 - 6.2 6.9 49.6 0.092 12.8 19.2 3.1 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DUF948 PF06103.11 ETO14362.1 - 0.0026 18.0 2.5 0.0031 17.7 2.5 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) CALCOCO1 PF07888.11 ETO14362.1 - 0.021 13.7 11.0 0.024 13.5 11.0 1.0 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like CENP-H PF05837.12 ETO14362.1 - 0.032 14.6 11.5 0.037 14.5 11.5 1.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4200 PF13863.6 ETO14362.1 - 0.042 14.3 13.3 0.063 13.7 13.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) DUF4839 PF16127.5 ETO14362.1 - 0.043 13.9 0.2 0.055 13.6 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4839) Sugarporin_N PF11471.8 ETO14362.1 - 0.046 13.7 0.1 0.046 13.7 0.1 1.9 2 0 0 2 2 2 0 Maltoporin periplasmic N-terminal extension XhlA PF10779.9 ETO14362.1 - 0.062 13.5 11.6 0.19 12.0 5.7 2.3 1 1 1 2 2 2 0 Haemolysin XhlA Nup54 PF13874.6 ETO14362.1 - 0.082 13.0 7.3 0.1 12.7 7.3 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 GAS PF13851.6 ETO14362.1 - 0.1 12.0 15.4 0.27 10.6 15.4 1.6 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding FapA PF03961.13 ETO14362.1 - 0.15 10.7 13.0 0.17 10.5 13.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A ATG16 PF08614.11 ETO14362.1 - 0.17 12.1 13.8 0.18 12.0 13.8 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) PRKG1_interact PF15898.5 ETO14362.1 - 0.17 12.8 13.0 0.2 12.6 13.0 1.0 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Chordopox_L2 PF05803.12 ETO14362.1 - 0.2 11.5 0.2 0.33 10.8 0.2 1.4 1 0 0 1 1 1 0 Chordopoxvirus L2 protein APG6_N PF17675.1 ETO14362.1 - 0.27 11.8 15.0 1.7 9.2 12.2 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region Fmp27_WPPW PF10359.9 ETO14362.1 - 0.29 10.0 9.8 0.28 10.0 9.8 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain KELK PF15796.5 ETO14362.1 - 0.34 11.4 13.3 0.39 11.2 12.7 1.4 1 1 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Uso1_p115_C PF04871.13 ETO14362.1 - 0.47 10.8 13.9 0.52 10.7 13.9 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region BST2 PF16716.5 ETO14362.1 - 0.59 10.8 14.2 0.79 10.4 14.2 1.2 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Seryl_tRNA_N PF02403.22 ETO14362.1 - 0.6 10.4 12.0 1.2 9.4 12.0 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DivIVA PF05103.13 ETO14362.1 - 0.61 10.2 11.2 0.77 9.9 11.2 1.2 1 0 0 1 1 1 0 DivIVA protein DUF2802 PF10975.8 ETO14362.1 - 0.62 10.2 5.8 7.7 6.7 5.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2802) TMPIT PF07851.13 ETO14362.1 - 0.78 8.9 11.3 0.82 8.9 11.3 1.0 1 0 0 1 1 1 0 TMPIT-like protein UPF0242 PF06785.11 ETO14362.1 - 0.92 9.6 14.2 1.7 8.7 14.2 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Ax_dynein_light PF10211.9 ETO14362.1 - 1 9.3 15.9 2.2 8.2 15.9 1.5 1 1 0 1 1 1 0 Axonemal dynein light chain Swi5 PF07061.11 ETO14362.1 - 1 9.5 9.9 0.28 11.3 4.8 2.1 1 1 0 2 2 2 0 Swi5 Spc7 PF08317.11 ETO14362.1 - 1.1 8.0 14.0 1.3 7.8 14.0 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF16 PF01519.16 ETO14362.1 - 1.3 9.6 11.1 5.5 7.5 11.1 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 ZapB PF06005.12 ETO14362.1 - 1.4 9.4 14.0 0.16 12.5 6.9 2.0 1 1 0 1 1 1 0 Cell division protein ZapB FemAB PF02388.16 ETO14362.1 - 2.4 7.0 10.2 2.5 6.9 10.2 1.0 1 0 0 1 1 1 0 FemAB family Spc24 PF08286.11 ETO14362.1 - 2.5 8.4 13.6 18 5.6 13.6 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 V_ATPase_I PF01496.19 ETO14362.1 - 2.6 5.9 9.5 2.6 5.8 9.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3450 PF11932.8 ETO14362.1 - 2.9 7.2 10.8 3.9 6.7 10.8 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) DUF724 PF05266.14 ETO14362.1 - 3.4 7.5 12.1 3.8 7.3 12.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) DUF4407 PF14362.6 ETO14362.1 - 3.5 6.9 7.6 3.7 6.8 7.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DivIC PF04977.15 ETO14362.1 - 5.3 6.9 14.4 0.94 9.3 1.5 2.2 1 1 1 2 2 2 0 Septum formation initiator Roc PF08477.13 ETO14363.1 - 0.007 16.6 0.0 0.017 15.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO14363.1 - 0.011 15.8 0.8 0.092 12.8 0.0 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETO14363.1 - 0.021 14.9 5.9 0.27 11.3 0.7 2.1 2 0 0 2 2 2 0 Dynamin family tRNA-Thr_ED PF08915.11 ETO14363.1 - 0.023 14.7 0.3 0.035 14.2 0.3 1.3 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase TRAP_alpha PF03896.16 ETO14363.1 - 0.047 12.9 2.4 0.065 12.4 2.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PTPRCAP PF15713.5 ETO14363.1 - 0.21 11.9 8.4 0.34 11.2 8.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated RPN2_C PF18004.1 ETO14363.1 - 0.22 11.4 6.8 0.4 10.6 6.8 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ETO14363.1 - 0.25 10.1 0.1 0.26 10.0 0.1 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO14363.1 - 0.42 9.5 2.4 0.66 8.9 2.4 1.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4298 PF14131.6 ETO14364.1 - 1.8 8.6 7.3 12 6.0 0.1 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF4298) Actin PF00022.19 ETO14367.1 - 2e-22 79.4 0.0 1e-21 77.0 0.0 1.9 1 1 0 1 1 1 1 Actin CENP-B_dimeris PF09026.10 ETO14367.1 - 0.45 10.9 8.8 1.3 9.5 8.8 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DFRP_C PF16543.5 ETO14367.1 - 0.52 10.8 5.3 0.43 11.1 0.9 2.2 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Aminotran_1_2 PF00155.21 ETO14368.1 - 6.7e-10 38.7 0.0 9.1e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II DUF3429 PF11911.8 ETO14369.1 - 0.11 12.8 0.6 0.15 12.3 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3429) zf-C3HC4_3 PF13920.6 ETO14370.1 - 1e-10 41.3 10.4 1.9e-10 40.4 10.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO14370.1 - 1.1e-05 25.1 13.2 8.4e-05 22.3 13.7 2.1 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO14370.1 - 1.9e-05 24.9 13.1 1.9e-05 24.9 13.1 2.0 2 0 0 2 2 2 1 Ring finger domain Tudor-knot PF11717.8 ETO14370.1 - 0.00013 21.8 1.2 0.00033 20.5 1.2 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Phage_integr_3 PF16795.5 ETO14370.1 - 0.099 12.6 1.0 0.22 11.4 1.0 1.6 1 0 0 1 1 1 0 Archaeal phage integrase DUF2457 PF10446.9 ETO14370.1 - 0.49 9.5 28.9 0.9 8.6 13.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) DUF2203 PF09969.9 ETO14370.1 - 1 10.1 7.3 0.48 11.2 0.7 2.7 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2203) DUF1272 PF06906.11 ETO14370.1 - 2 8.5 9.3 6.7 6.9 9.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) ADD_DNMT3 PF17980.1 ETO14370.1 - 2.1 8.4 6.7 5.9 7.0 6.7 1.8 1 0 0 1 1 1 0 Cysteine rich ADD domain in DNMT3 DUF4611 PF15387.6 ETO14370.1 - 2.4 8.4 15.9 0.96 9.7 2.6 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) zf-RING_UBOX PF13445.6 ETO14370.1 - 2.7 8.1 10.2 2.6 8.1 6.8 2.5 1 1 1 2 2 2 0 RING-type zinc-finger SAM_2 PF07647.17 ETO14370.1 - 3.3 7.9 8.5 0.99 9.6 0.5 3.5 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO14371.1 - 3e-65 214.6 16.7 2e-11 44.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14371.1 - 5.5e-28 97.1 2.5 0.00027 21.2 0.0 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14371.1 - 1.1e-15 57.4 0.2 0.017 14.1 0.0 6.2 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14371.1 - 4.3e-10 39.4 0.6 0.00093 18.6 0.0 5.0 2 1 3 6 6 6 4 WD40-like domain eIF2A PF08662.11 ETO14371.1 - 7.1e-10 39.1 0.6 0.00016 21.7 0.1 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO14371.1 - 4.6e-08 32.2 6.4 0.15 10.7 0.1 5.4 2 2 3 6 6 6 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO14371.1 - 9.4e-08 32.2 1.9 2 8.5 0.0 5.7 2 1 4 6 6 6 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO14371.1 - 3.4e-06 25.8 0.8 0.028 13.0 0.0 3.4 1 1 3 4 4 4 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO14371.1 - 3.9e-06 26.5 2.0 1.4 8.9 0.0 5.6 5 1 1 6 6 6 1 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO14371.1 - 2.7e-05 23.1 2.9 4.6 5.9 0.0 4.7 1 1 3 5 5 5 1 Nup133 N terminal like PD40 PF07676.12 ETO14371.1 - 3.1e-05 23.8 8.2 3.2 7.8 0.1 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO14371.1 - 9.5e-05 21.9 1.3 2 7.7 0.0 4.3 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO14371.1 - 0.00018 21.2 0.5 0.0069 16.0 0.1 2.9 1 1 1 2 2 2 1 PQQ-like domain DUF727 PF05303.12 ETO14371.1 - 0.00054 20.0 0.0 3.7 7.7 0.0 3.6 2 1 1 3 3 3 1 Protein of unknown function (DUF727) PALB2_WD40 PF16756.5 ETO14371.1 - 0.00092 18.2 2.7 1.8 7.4 0.1 4.1 1 1 3 4 4 4 2 Partner and localizer of BRCA2 WD40 domain DUF5046 PF16465.5 ETO14371.1 - 0.0027 17.2 0.0 0.082 12.3 0.0 2.6 1 1 2 3 3 3 1 Domain of unknown function (DUF5046) DHFR_2 PF06442.11 ETO14371.1 - 0.0033 17.2 0.0 2.6 8.0 0.0 3.9 4 1 1 5 5 5 1 R67 dihydrofolate reductase Peptidase_M14 PF00246.24 ETO14371.1 - 0.049 13.4 0.0 8.4 6.1 0.0 2.6 2 1 0 2 2 2 0 Zinc carboxypeptidase TolB_N PF04052.13 ETO14371.1 - 0.054 13.7 0.6 97 3.2 0.0 4.6 6 0 0 6 6 4 0 TolB amino-terminal domain DUF1854 PF08909.11 ETO14371.1 - 0.061 13.1 2.7 18 5.2 0.1 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF1854) Me-amine-dh_H PF06433.11 ETO14371.1 - 0.062 12.2 0.0 2.6 6.8 0.0 2.8 1 1 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) Frtz PF11768.8 ETO14371.1 - 0.12 10.7 0.0 0.95 7.7 0.0 2.2 1 1 2 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz SBD PF17882.1 ETO14371.1 - 0.14 12.0 0.8 1.4 8.8 0.2 2.5 1 1 2 3 3 3 0 OAA-family lectin sugar binding domain Proteasome_A_N PF10584.9 ETO14371.1 - 1.2 8.8 8.9 61 3.4 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Ras PF00071.22 ETO14372.1 - 6.9e-25 87.5 0.1 6.2e-20 71.4 0.0 2.3 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO14372.1 - 6.6e-08 32.8 0.9 0.0062 16.8 0.0 2.6 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO14372.1 - 0.0052 16.3 0.4 0.044 13.2 0.1 2.1 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF5534 PF17686.1 ETO14373.1 - 4.7 7.4 10.3 0.51 10.6 3.7 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5534) WD40 PF00400.32 ETO14374.1 - 3.2e-67 220.8 12.2 1.9e-11 44.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14374.1 - 5e-24 84.4 0.2 6.9e-05 23.1 0.0 5.9 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14374.1 - 6.1e-13 48.4 0.1 0.018 14.0 0.0 5.7 2 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14374.1 - 4.2e-12 46.0 0.4 0.00011 21.6 0.0 3.3 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO14374.1 - 4.4e-07 28.9 3.4 1.7 7.2 0.0 5.6 1 1 4 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO14374.1 - 6.2e-07 29.2 7.2 3.1 7.9 0.2 6.0 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO14374.1 - 2e-05 24.7 1.8 0.61 10.2 0.1 4.4 2 1 2 4 4 4 2 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO14374.1 - 0.00017 21.3 0.3 0.0065 16.1 0.1 2.7 1 1 0 1 1 1 1 PQQ-like domain DUF4072 PF13284.6 ETO14374.1 - 0.00023 21.5 0.0 13 6.4 0.0 4.9 5 0 0 5 5 5 0 Domain of unknown function (DUF4072) PALB2_WD40 PF16756.5 ETO14374.1 - 0.0012 17.8 0.9 7.9 5.3 0.0 4.3 2 1 2 5 5 5 1 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO14374.1 - 0.0017 17.8 1.1 6.9 5.9 0.0 3.9 1 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO14374.1 - 0.0025 16.9 0.0 5.2 6.0 0.0 3.2 2 1 1 4 4 4 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ETO14374.1 - 0.0027 16.3 0.2 0.022 13.3 0.0 2.2 2 1 1 3 3 3 1 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO14374.1 - 0.003 17.2 1.3 23 4.8 0.0 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF727 PF05303.12 ETO14374.1 - 0.0042 17.1 0.1 8.9 6.4 0.0 4.5 1 1 2 5 5 5 0 Protein of unknown function (DUF727) Coatomer_WDAD PF04053.14 ETO14374.1 - 0.0043 16.2 0.1 0.88 8.5 0.0 2.3 1 1 1 2 2 2 2 Coatomer WD associated region PQQ PF01011.21 ETO14374.1 - 0.011 15.6 0.0 3.2 7.8 0.0 4.4 6 0 0 6 6 5 0 PQQ enzyme repeat DUF4221 PF13970.6 ETO14374.1 - 0.018 14.6 0.4 0.99 8.9 0.0 2.9 1 1 3 4 4 4 0 Domain of unknown function (DUF4221) SBD PF17882.1 ETO14374.1 - 0.032 14.1 2.7 12 5.7 0.0 3.9 2 2 2 4 4 4 0 OAA-family lectin sugar binding domain WG_beta_rep PF14903.6 ETO14374.1 - 0.044 14.1 0.0 22 5.4 0.0 3.8 3 0 0 3 3 3 0 WG containing repeat Det1 PF09737.9 ETO14374.1 - 0.058 12.4 0.2 0.16 11.0 0.1 1.7 2 0 0 2 2 2 0 De-etiolated protein 1 Det1 Big_7 PF17957.1 ETO14374.1 - 0.067 14.0 0.4 7.3 7.4 0.0 3.6 3 1 0 3 3 3 0 Bacterial Ig domain WD40 PF00400.32 ETO14375.1 - 1.9e-63 208.9 22.7 3.7e-10 40.2 0.5 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14375.1 - 1.9e-20 72.9 3.3 0.0043 17.3 0.0 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14375.1 - 9.7e-11 41.2 0.2 0.27 10.2 0.0 6.1 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO14375.1 - 5.7e-09 35.2 4.0 1.1 7.8 0.0 5.9 1 1 4 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO14375.1 - 6e-09 35.6 5.5 0.012 15.0 0.0 3.6 2 1 2 4 4 4 3 WD40-like domain Nucleoporin_N PF08801.11 ETO14375.1 - 8.5e-05 21.5 4.9 0.44 9.2 0.0 4.8 1 1 5 6 6 6 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO14375.1 - 0.00028 19.6 1.3 0.46 9.0 0.0 3.0 1 1 2 4 4 4 3 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO14375.1 - 0.00042 19.4 0.2 2.3 7.0 0.0 4.1 1 1 3 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Me-amine-dh_H PF06433.11 ETO14375.1 - 0.0016 17.4 0.0 0.13 11.1 0.0 2.6 2 1 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) SGL PF08450.12 ETO14375.1 - 0.0026 17.4 0.5 0.57 9.7 0.1 2.6 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region PQQ PF01011.21 ETO14375.1 - 0.0049 16.7 0.0 24 5.1 0.0 4.8 5 0 0 5 5 5 0 PQQ enzyme repeat DUF5570 PF17731.1 ETO14375.1 - 0.014 15.4 1.0 7 6.8 0.0 4.4 1 1 4 6 6 6 0 Family of unknown function (DUF5570) Colicin_im PF03857.13 ETO14375.1 - 0.023 14.7 0.3 0.036 14.0 0.3 1.2 1 0 0 1 1 1 0 Colicin immunity protein Nbas_N PF15492.6 ETO14375.1 - 0.024 14.0 1.3 3.3 7.0 0.9 3.9 1 1 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO14375.1 - 0.21 11.6 8.3 4.6 7.3 0.1 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat ComS PF17584.2 ETO14375.1 - 2.9 7.5 9.8 1.7 8.2 0.0 4.3 5 0 0 5 5 5 0 Bacillus competence protein S Comm PF15957.5 ETO14377.1 - 0.016 15.5 0.3 0.016 15.5 0.3 2.1 3 0 0 3 3 3 0 Commissureless Ax_dynein_light PF10211.9 ETO14378.1 - 3.6 7.5 12.4 5.8 6.8 12.4 1.4 1 0 0 1 1 1 0 Axonemal dynein light chain FH2 PF02181.23 ETO14380.1 - 4.8e-08 32.5 2.9 4.8e-08 32.5 2.9 2.4 1 1 1 3 3 3 1 Formin Homology 2 Domain DUF4611 PF15387.6 ETO14380.1 - 3.5 7.9 17.1 0.5 10.6 12.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 ETO14380.1 - 3.8 8.0 12.7 8.8 6.8 12.7 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3042 PF11240.8 ETO14380.1 - 6.5 6.9 7.9 0.31 11.1 0.7 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3042) FAM176 PF14851.6 ETO14380.1 - 9.7 5.8 13.0 3.1 7.4 4.8 2.4 2 0 0 2 2 2 0 FAM176 family ECF_trnsprt PF12822.7 ETO14381.1 - 3 7.9 13.1 0.74 9.9 10.1 1.5 2 0 0 2 2 2 0 ECF transporter, substrate-specific component Guanylate_cyc PF00211.20 ETO14382.1 - 1.3e-24 86.8 0.3 4.7e-24 85.0 0.3 2.0 1 1 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain sCache_3_3 PF17202.4 ETO14382.1 - 0.039 14.4 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 Single cache domain 3 Desulfoferrod_N PF06397.12 ETO14382.1 - 1.5 8.5 7.5 6.9 6.4 0.4 2.6 2 0 0 2 2 2 0 Desulfoferrodoxin, N-terminal domain CUB PF00431.20 ETO14383.1 - 0.0021 18.4 2.4 0.23 11.8 0.3 2.6 2 0 0 2 2 2 2 CUB domain P-mevalo_kinase PF04275.14 ETO14383.1 - 0.044 13.7 1.3 0.099 12.6 0.2 2.2 2 0 0 2 2 2 0 Phosphomevalonate kinase PUB PF09409.10 ETO14383.1 - 0.12 12.3 2.4 0.12 12.3 0.2 2.2 2 0 0 2 2 2 0 PUB domain WD40 PF00400.32 ETO14384.1 - 1.6e-41 139.5 11.1 1.4e-09 38.4 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14384.1 - 8.4e-16 58.1 0.8 0.00042 20.6 0.0 4.9 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14384.1 - 1.1e-06 27.9 0.4 0.19 10.6 0.0 4.0 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO14384.1 - 1.5e-06 28.3 0.1 0.012 15.5 0.1 3.4 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO14384.1 - 0.00013 20.7 0.0 0.0025 16.4 0.0 2.1 2 0 0 2 2 2 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO14384.1 - 0.00022 20.0 0.1 0.61 8.7 0.0 3.2 3 1 0 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO14384.1 - 0.001 18.4 1.8 0.39 10.0 0.6 2.4 2 0 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO14384.1 - 0.0022 17.9 0.9 2 8.4 0.0 4.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat CBM39 PF15886.5 ETO14384.1 - 0.014 15.3 0.5 0.062 13.2 0.0 2.1 2 0 0 2 2 2 0 Carbohydrate binding domain (family 32) DUF5570 PF17731.1 ETO14384.1 - 0.022 14.9 0.3 3.4 7.8 0.0 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO14384.1 - 0.061 12.1 1.3 0.7 8.6 0.1 2.9 2 1 2 4 4 4 0 Nup133 N terminal like WD40 PF00400.32 ETO14385.1 - 6.2e-69 226.2 23.2 2.3e-09 37.7 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14385.1 - 1.6e-21 76.4 4.5 0.016 15.5 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14385.1 - 2.2e-15 56.5 2.2 0.0011 18.0 0.2 5.4 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14385.1 - 2.6e-09 36.8 1.7 0.0015 17.9 0.1 2.9 1 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO14385.1 - 1e-06 27.8 5.9 2.4 6.7 0.0 6.1 1 1 6 7 7 7 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO14385.1 - 5.9e-06 25.1 0.5 0.019 13.5 0.1 3.4 1 1 2 3 3 3 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO14385.1 - 1.5e-05 24.8 0.6 2.6 8.1 0.0 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO14385.1 - 7.9e-05 22.2 0.4 1.9 8.2 0.0 4.7 6 0 0 6 6 6 2 HepA-related protein (HARP) Nbas_N PF15492.6 ETO14385.1 - 9.6e-05 21.8 0.6 0.48 9.7 0.0 3.3 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF1797 PF08796.10 ETO14385.1 - 0.0062 16.6 0.0 6.8 6.9 0.0 3.1 3 1 1 4 4 4 1 Protein of unknown function (DUF1797) Nucleoporin_N PF08801.11 ETO14385.1 - 0.021 13.6 11.9 4.9 5.8 0.0 5.2 1 1 3 5 5 5 0 Nup133 N terminal like DUF5046 PF16465.5 ETO14385.1 - 0.023 14.2 0.0 0.97 8.8 0.0 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF5046) Resistin PF06954.11 ETO14385.1 - 0.023 15.2 0.5 72 4.0 0.0 3.8 3 1 1 4 4 4 0 Resistin Utp8 PF10395.9 ETO14385.1 - 0.025 13.1 0.0 2 6.8 0.0 2.4 1 1 2 3 3 3 0 Utp8 family Proteasome_A_N PF10584.9 ETO14385.1 - 0.048 13.3 0.4 23 4.8 0.0 3.4 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Me-amine-dh_H PF06433.11 ETO14385.1 - 0.055 12.3 0.0 2.3 7.0 0.0 2.6 2 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) DUF4265 PF14085.6 ETO14385.1 - 0.078 12.9 0.2 4.1 7.4 0.0 3.3 2 2 2 4 4 4 0 Domain of unknown function (DUF4265) DUF4221 PF13970.6 ETO14385.1 - 0.12 11.9 0.1 8 5.9 0.0 3.1 1 1 2 4 4 4 0 Domain of unknown function (DUF4221) ROS_MUCR PF05443.11 ETO14385.1 - 0.32 11.1 0.6 64 3.6 0.0 3.5 4 1 0 4 4 4 0 ROS/MUCR transcriptional regulator protein Guanylate_cyc PF00211.20 ETO14386.1 - 7.8e-20 71.3 0.0 1.1e-19 70.8 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Pkinase_fungal PF17667.1 ETO14387.1 - 0.03 13.1 6.3 0.033 13.0 6.3 1.1 1 0 0 1 1 1 0 Fungal protein kinase NCD2 PF04905.13 ETO14387.1 - 0.25 11.3 6.0 0.35 10.8 6.0 1.2 1 0 0 1 1 1 0 NAB conserved region 2 (NCD2) ATC_hydrolase PF14196.6 ETO14387.1 - 0.46 11.3 5.0 0.59 10.9 5.0 1.2 1 0 0 1 1 1 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase FAM60A PF15396.6 ETO14387.1 - 0.59 10.1 12.1 0.69 9.9 12.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A ETRAMP PF09716.10 ETO14387.1 - 2.3 8.4 11.5 12 6.1 11.5 2.1 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DEAD PF00270.29 ETO14390.1 - 1.8e-45 154.8 0.3 1.8e-45 154.8 0.3 2.3 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO14390.1 - 3.1e-27 95.1 0.1 3.1e-27 95.1 0.1 5.2 4 1 2 6 6 6 2 Helicase conserved C-terminal domain Bestrophin PF01062.21 ETO14390.1 - 3.6 6.9 6.3 9.6 5.5 6.3 1.7 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel LIM PF00412.22 ETO14391.1 - 0.016 15.4 7.4 0.04 14.1 2.9 2.7 2 0 0 2 2 2 0 LIM domain zf-RING_5 PF14634.6 ETO14391.1 - 0.29 11.1 11.5 0.93 9.5 11.5 2.0 1 0 0 1 1 1 0 zinc-RING finger domain ARL6IP6 PF15062.6 ETO14391.1 - 0.52 10.5 3.0 6.1 7.0 0.5 2.5 2 0 0 2 2 2 0 Haemopoietic lineage transmembrane helix PADR1 PF08063.12 ETO14391.1 - 1.2 9.0 6.1 70 3.3 6.0 2.6 1 1 1 2 2 2 0 PADR1 (NUC008) domain ATG16 PF08614.11 ETO14392.1 - 0.028 14.6 0.2 0.047 13.9 0.2 1.3 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) GP41 PF00517.17 ETO14392.1 - 0.069 13.0 0.4 0.069 13.0 0.4 1.9 2 2 0 2 2 2 0 Retroviral envelope protein WD40 PF00400.32 ETO14394.1 - 0.025 15.4 2.3 0.55 11.2 0.1 2.7 2 1 0 2 2 2 0 WD domain, G-beta repeat WD40 PF00400.32 ETO14395.1 - 3.5e-07 30.8 0.4 0.0079 17.0 0.0 3.5 3 2 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14395.1 - 0.035 14.4 0.0 7.4 6.9 0.0 2.7 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14395.1 - 0.15 10.7 0.2 1.8 7.1 0.2 1.9 1 1 0 1 1 1 0 Nucleoporin Nup120/160 COG2 PF06148.11 ETO14396.1 - 0.021 14.9 0.1 0.034 14.2 0.1 1.3 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 MBG PF17883.1 ETO14396.1 - 0.032 14.8 0.2 0.059 14.0 0.2 1.4 1 0 0 1 1 1 0 MBG domain Rieske PF00355.26 ETO14397.1 - 4.6e-08 32.9 0.4 8e-07 28.9 0.4 2.2 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain ATP-synt_G PF04718.15 ETO14398.1 - 0.023 15.5 0.0 0.043 14.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ATP synthase g subunit Pribosyltran PF00156.27 ETO14399.1 - 5.3e-26 91.0 0.0 7.1e-26 90.6 0.0 1.1 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ETO14399.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase FragX_IP PF05994.11 ETO14400.1 - 2.7e-05 22.5 0.0 3.4e-05 22.1 0.0 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family FragX_IP PF05994.11 ETO14401.1 - 1.7e-131 439.9 6.7 2.3e-131 439.5 6.7 1.0 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family FragX_IP PF05994.11 ETO14402.1 - 4.5e-25 87.9 0.1 5e-24 84.4 0.0 2.0 2 0 0 2 2 2 2 Cytoplasmic Fragile-X interacting family DUF1394 PF07159.12 ETO14402.1 - 4.4e-07 29.5 0.1 1.1e-06 28.2 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) WD40 PF00400.32 ETO14404.1 - 4.5e-62 204.5 13.2 9.3e-09 35.8 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14404.1 - 4.9e-23 81.2 3.0 0.0025 18.1 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14404.1 - 2.9e-14 52.8 1.2 0.018 14.0 0.0 6.0 1 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO14404.1 - 8.6e-11 41.2 7.6 0.1 11.2 0.1 6.3 1 1 5 7 7 7 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO14404.1 - 3.9e-09 36.3 1.7 0.0005 19.5 0.0 3.6 2 1 2 4 4 4 3 WD40-like domain PQQ PF01011.21 ETO14404.1 - 6.4e-07 29.0 0.0 1.5 8.9 0.0 5.6 5 0 0 5 5 5 1 PQQ enzyme repeat PQQ_2 PF13360.6 ETO14404.1 - 1.8e-06 27.8 3.4 0.007 16.0 0.3 2.6 1 1 0 2 2 2 2 PQQ-like domain Me-amine-dh_H PF06433.11 ETO14404.1 - 2.4e-06 26.7 0.3 0.002 17.1 0.0 2.4 2 1 0 2 2 2 2 Methylamine dehydrogenase heavy chain (MADH) Gmad1 PF10647.9 ETO14404.1 - 6.3e-05 22.9 0.2 0.015 15.1 0.2 3.0 1 1 1 2 2 2 1 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.6 ETO14404.1 - 8.5e-05 22.0 0.3 0.016 14.6 0.0 3.3 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DUF2963 PF11178.8 ETO14404.1 - 0.00038 20.1 0.2 0.13 12.0 0.0 4.9 4 2 1 5 5 5 1 Protein of unknown function (DUF2963) Cytochrom_D1 PF02239.16 ETO14404.1 - 0.0012 17.4 1.1 2.1 6.8 0.1 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO14404.1 - 0.011 15.8 1.5 0.54 10.4 0.0 3.8 2 2 3 5 5 5 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO14404.1 - 0.015 15.2 4.6 7.6 6.6 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat CHAP PF05257.16 ETO14404.1 - 0.016 15.8 6.4 9.3 6.9 0.1 4.3 1 1 3 5 5 5 0 CHAP domain Ret2_MD PF18528.1 ETO14404.1 - 0.049 14.0 0.2 1.9 8.9 0.0 3.2 4 1 1 5 5 4 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Str_synth PF03088.16 ETO14404.1 - 0.049 13.7 0.1 13 6.0 0.0 3.4 3 1 1 4 4 3 0 Strictosidine synthase IKI3 PF04762.12 ETO14404.1 - 0.068 11.2 2.1 1.5 6.7 0.0 2.3 1 1 0 2 2 2 0 IKI3 family Peptidase_C14 PF00656.22 ETO14405.1 - 3.2e-12 46.9 0.3 3.5e-11 43.6 0.3 2.4 1 1 1 2 2 2 1 Caspase domain Kelch_1 PF01344.25 ETO14405.1 - 0.0012 18.3 0.3 0.0012 18.3 0.3 2.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO14405.1 - 0.0048 16.9 0.2 0.012 15.6 0.2 1.7 1 0 0 1 1 1 1 Galactose oxidase, central domain CDC45 PF02724.14 ETO14405.1 - 0.0081 14.5 12.2 0.011 14.1 12.2 1.2 1 0 0 1 1 1 1 CDC45-like protein Kelch_5 PF13854.6 ETO14405.1 - 0.016 15.2 0.3 0.036 14.0 0.3 1.7 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 ETO14405.1 - 0.059 13.7 0.6 0.27 11.6 0.1 2.4 2 0 0 2 2 2 0 Kelch motif DDHD PF02862.17 ETO14405.1 - 0.2 11.8 5.3 0.36 11.0 5.3 1.4 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 ETO14405.1 - 0.68 9.7 21.3 1.5 8.6 21.3 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO14405.1 - 0.95 8.6 4.1 1.3 8.2 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc4 PF05132.14 ETO14405.1 - 1.9 8.9 8.8 3.4 8.1 8.8 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_11 PF13086.6 ETO14405.1 - 3.7 7.3 16.9 7.7 6.2 16.9 1.5 1 0 0 1 1 1 0 AAA domain Vfa1 PF08432.10 ETO14405.1 - 9.2 6.5 28.3 22 5.3 28.3 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CobT PF06213.12 ETO14405.1 - 9.4 5.5 18.5 15 4.9 18.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Vac14_Fig4_bd PF11916.8 ETO14406.1 - 2.2e-52 177.3 8.9 2.2e-52 177.3 8.9 2.2 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding Cnd1 PF12717.7 ETO14406.1 - 0.0088 16.1 2.4 0.021 14.9 2.3 1.9 1 1 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO14406.1 - 0.17 12.3 1.6 0.38 11.1 0.2 2.3 2 0 0 2 2 2 0 HEAT repeat CLASP_N PF12348.8 ETO14407.1 - 2.1e-06 27.5 0.2 0.0001 22.0 0.0 2.1 1 1 1 2 2 2 1 CLASP N terminal Cnd1 PF12717.7 ETO14407.1 - 0.00036 20.6 0.8 0.015 15.3 0.2 2.1 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Dopey_N PF04118.14 ETO14407.1 - 0.0021 17.2 0.8 0.028 13.6 0.3 1.9 1 1 1 2 2 2 2 Dopey, N-terminal Vac14_Fab1_bd PF12755.7 ETO14407.1 - 0.0034 17.9 0.0 0.3 11.7 0.0 2.1 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region SMK-1 PF04802.15 ETO14407.1 - 0.0059 16.5 0.2 0.048 13.5 0.2 2.4 1 1 0 1 1 1 1 Component of IIS longevity pathway SMK-1 HEAT PF02985.22 ETO14407.1 - 0.043 14.1 0.4 41 4.8 0.0 3.6 4 0 0 4 4 4 0 HEAT repeat HEAT_EZ PF13513.6 ETO14407.1 - 0.06 13.9 0.5 16 6.2 0.0 3.1 3 0 0 3 3 3 0 HEAT-like repeat ATP-synt_ab PF00006.25 ETO14408.1 - 8.1e-27 94.3 1.4 7.3e-23 81.3 0.2 2.0 2 0 0 2 2 2 2 ATP synthase alpha/beta family, nucleotide-binding domain NB-ARC PF00931.22 ETO14408.1 - 0.014 14.6 0.2 0.017 14.3 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain NACHT PF05729.12 ETO14408.1 - 0.021 14.7 0.2 0.16 11.9 0.1 2.1 1 1 0 2 2 2 0 NACHT domain RsgA_GTPase PF03193.16 ETO14408.1 - 0.052 13.5 0.0 0.069 13.0 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 ETO14408.1 - 0.11 12.5 0.0 1.8 8.6 0.1 2.2 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 ETO14408.1 - 0.11 12.3 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_19 PF13245.6 ETO14408.1 - 0.14 12.5 0.2 0.24 11.7 0.2 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO14408.1 - 0.19 12.2 0.3 0.34 11.4 0.3 1.4 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 ETO14408.1 - 0.25 10.7 0.6 0.32 10.3 0.6 1.2 1 0 0 1 1 1 0 KaiC Cofilin_ADF PF00241.20 ETO14410.1 - 5.5e-26 90.7 3.4 9e-14 51.3 0.6 2.1 2 0 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein WD40 PF00400.32 ETO14411.1 - 1.1e-57 190.6 14.4 1.8e-10 41.2 0.1 8.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14411.1 - 1e-21 77.0 1.1 0.0014 18.9 0.0 7.7 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14411.1 - 2.1e-16 59.8 2.1 0.0079 15.2 0.0 7.3 2 1 6 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO14411.1 - 4e-10 39.6 2.7 0.00021 21.4 0.0 4.1 4 0 0 4 4 3 2 Kelch motif WD40_like PF17005.5 ETO14411.1 - 1.7e-06 27.6 3.1 0.14 11.4 0.1 3.9 4 0 0 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO14411.1 - 7.5e-05 21.6 2.8 0.49 9.0 0.1 4.9 1 1 3 5 5 5 1 Nucleoporin Nup120/160 Kelch_5 PF13854.6 ETO14411.1 - 9.8e-05 22.2 1.4 0.31 11.1 0.0 4.4 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO14411.1 - 0.00013 21.5 1.9 0.15 11.7 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO14411.1 - 0.00021 21.2 0.2 0.0062 16.5 0.0 3.3 3 0 0 3 3 2 1 Galactose oxidase, central domain 14-3-3 PF00244.20 ETO14411.1 - 0.0067 16.0 0.1 0.013 15.0 0.1 1.4 1 0 0 1 1 1 1 14-3-3 protein nos_propeller PF18764.1 ETO14411.1 - 0.0074 16.2 0.1 5.5 7.0 0.0 3.2 3 0 0 3 3 3 1 Nitrous oxide reductase propeller repeat Cytochrom_D1 PF02239.16 ETO14411.1 - 0.0089 14.6 0.3 0.53 8.8 0.1 3.0 1 1 2 3 3 3 1 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO14411.1 - 0.037 14.0 5.4 6.5 6.9 0.2 4.5 4 1 0 4 4 4 0 Kelch motif BBS2_Mid PF14783.6 ETO14411.1 - 0.065 13.3 1.9 31 4.7 0.1 4.9 4 3 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region PKD PF00801.20 ETO14411.1 - 0.098 12.5 0.3 0.62 9.9 0.0 2.5 2 1 0 2 2 2 0 PKD domain PQQ_2 PF13360.6 ETO14411.1 - 0.13 11.8 0.1 0.48 10.0 0.1 2.0 1 1 1 2 2 2 0 PQQ-like domain PD40 PF07676.12 ETO14411.1 - 0.27 11.2 16.7 3.8 7.5 0.2 6.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat MscS_TM PF12794.7 ETO14412.1 - 0.25 10.2 2.3 0.29 10.0 2.3 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 SURF2 PF05477.11 ETO14412.1 - 0.31 10.7 14.6 0.35 10.5 14.6 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DEAD PF00270.29 ETO14413.1 - 5.1e-41 140.3 0.0 1.1e-40 139.3 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO14413.1 - 3.3e-24 85.4 0.1 1.2e-23 83.5 0.1 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF4217 PF13959.6 ETO14413.1 - 2.5e-09 37.2 0.1 5.5e-09 36.1 0.1 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) ERCC3_RAD25_C PF16203.5 ETO14413.1 - 0.0076 15.5 0.1 0.019 14.2 0.1 1.6 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_2 PF13307.6 ETO14413.1 - 0.13 12.5 0.0 0.43 10.7 0.0 1.9 1 0 0 1 1 1 0 Helicase C-terminal domain Glycolytic PF00274.19 ETO14414.1 - 4.7e-69 232.8 0.0 5.2e-69 232.6 0.0 1.0 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I GAF_2 PF13185.6 ETO14415.1 - 3.5e-05 24.1 0.1 0.00052 20.3 0.1 2.3 1 1 0 1 1 1 1 GAF domain H_kinase_N PF12282.8 ETO14415.1 - 0.02 14.8 0.1 0.043 13.8 0.1 1.6 1 0 0 1 1 1 0 Signal transduction histidine kinase PAS_4 PF08448.10 ETO14415.1 - 0.035 14.4 0.0 0.22 11.8 0.0 2.3 3 0 0 3 3 3 0 PAS fold DUF1722 PF08349.11 ETO14415.1 - 0.14 12.5 0.4 0.46 10.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) TPR_10 PF13374.6 ETO14416.1 - 6e-09 35.5 0.0 0.00062 19.6 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO14416.1 - 7.6e-09 35.7 0.1 4.9e-08 33.2 0.0 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14416.1 - 1.2e-08 34.4 8.3 1.6e-05 24.5 1.5 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14416.1 - 1.7e-07 30.8 5.0 0.002 18.1 0.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14416.1 - 4.8e-07 29.5 6.8 0.0042 17.2 0.7 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14416.1 - 1.9e-06 27.5 0.1 0.033 14.2 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO14416.1 - 0.0011 18.7 6.8 0.022 14.5 1.0 2.0 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO14416.1 - 0.0013 18.8 4.8 0.16 12.0 0.0 3.2 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO14416.1 - 0.037 13.7 5.0 2.7 7.8 0.1 3.1 3 1 0 3 3 3 0 TPR repeat TPR_17 PF13431.6 ETO14416.1 - 3.1 8.4 5.2 1.7 9.2 0.5 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat Ank_5 PF13857.6 ETO14417.1 - 1.7e-28 98.3 2.6 6e-07 29.6 0.1 5.4 3 2 2 5 5 5 5 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO14417.1 - 1.6e-22 79.9 1.1 3.3e-13 50.0 0.0 3.9 3 1 1 4 4 4 3 Ankyrin repeats (3 copies) Ank PF00023.30 ETO14417.1 - 6.9e-22 76.9 2.6 1.1e-05 25.7 0.1 5.6 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ETO14417.1 - 1.4e-21 76.5 1.8 1.2e-10 41.7 0.0 4.5 4 1 0 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO14417.1 - 9.9e-21 71.6 2.5 0.00016 21.8 0.0 6.1 5 1 0 5 5 5 5 Ankyrin repeat PrgH PF09480.10 ETO14417.1 - 0.033 13.5 0.0 0.058 12.7 0.0 1.3 1 0 0 1 1 1 0 Type III secretion system protein PrgH-EprH (PrgH) ATG16 PF08614.11 ETO14418.1 - 0.0051 17.1 5.3 0.0051 17.1 5.3 3.2 2 1 0 3 3 3 2 Autophagy protein 16 (ATG16) Lectin_N PF03954.14 ETO14418.1 - 0.27 11.0 10.7 0.76 9.5 0.8 3.1 3 0 0 3 3 3 0 Hepatic lectin, N-terminal domain Utp12 PF04003.12 ETO14418.1 - 0.91 9.9 6.4 6.9 7.0 0.3 3.0 3 0 0 3 3 3 0 Dip2/Utp12 Family DUF4763 PF15960.5 ETO14418.1 - 3.8 6.8 36.8 0.027 13.8 13.5 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4763) DUF1664 PF07889.12 ETO14418.1 - 4.9 7.2 24.5 0.1 12.6 4.0 3.9 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) WD40 PF00400.32 ETO14419.1 - 6.3e-14 52.2 12.0 0.0019 19.0 1.5 6.9 8 0 0 8 8 8 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO14419.1 - 7e-06 26.0 7.6 0.002 18.1 0.2 4.9 6 1 0 6 6 6 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 ETO14419.1 - 0.00064 20.0 3.4 1.2 9.5 0.7 5.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain DUF1106 PF06523.11 ETO14419.1 - 0.016 15.2 1.3 0.12 12.5 1.3 2.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1106) Myc-LZ PF02344.15 ETO14419.1 - 0.043 13.9 3.6 0.13 12.4 3.6 1.8 1 0 0 1 1 1 0 Myc leucine zipper domain Uds1 PF15456.6 ETO14419.1 - 0.39 10.9 7.0 1.1 9.4 7.0 1.7 1 1 0 1 1 1 0 Up-regulated During Septation kleA_kleC PF17383.2 ETO14419.1 - 0.5 10.7 3.2 0.75 10.2 0.7 2.4 1 1 2 3 3 3 0 Uncharacterized KorC regulated protein A PRE_C2HC PF07530.11 ETO14420.1 - 0.057 13.5 0.4 9.4 6.4 0.1 2.3 2 1 0 2 2 2 0 Associated with zinc fingers ATP-grasp_3 PF02655.14 ETO14420.1 - 0.11 12.6 0.0 0.11 12.5 0.0 1.1 1 0 0 1 1 1 0 ATP-grasp domain RNA_pol_3_Rpc31 PF11705.8 ETO14421.1 - 0.00072 19.9 16.9 0.00091 19.5 16.9 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 BSP_II PF05432.11 ETO14421.1 - 0.0011 18.8 14.2 0.0013 18.5 14.2 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 ETO14421.1 - 0.0011 18.5 21.2 0.0012 18.3 21.2 1.0 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO14421.1 - 0.01 14.1 20.4 0.011 14.0 20.4 1.0 1 0 0 1 1 1 0 Nop14-like family Zip PF02535.22 ETO14421.1 - 0.015 14.6 0.8 0.022 14.0 0.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 ETO14421.1 - 0.021 13.6 3.4 0.025 13.4 3.4 1.0 1 0 0 1 1 1 0 Raftlin PPP4R2 PF09184.11 ETO14421.1 - 0.022 14.4 19.2 0.03 13.9 19.2 1.2 1 0 0 1 1 1 0 PPP4R2 MRNIP PF15749.5 ETO14421.1 - 0.037 14.7 5.9 0.05 14.3 5.9 1.2 1 0 0 1 1 1 0 MRN-interacting protein SGT1 PF07093.11 ETO14421.1 - 0.038 12.5 9.7 0.043 12.3 9.7 1.1 1 0 0 1 1 1 0 SGT1 protein DUF4628 PF15429.6 ETO14421.1 - 0.046 13.4 3.9 0.065 12.9 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) DUF913 PF06025.12 ETO14421.1 - 0.11 11.5 1.6 0.1 11.5 1.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Cwf_Cwc_15 PF04889.12 ETO14421.1 - 0.11 12.2 21.5 0.14 11.9 21.5 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETO14421.1 - 0.15 10.4 20.2 0.17 10.2 20.2 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO14421.1 - 0.2 11.0 17.9 0.23 10.8 17.9 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 ETO14421.1 - 0.2 10.9 25.9 0.28 10.5 25.9 1.1 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.11 ETO14421.1 - 0.27 9.3 7.8 0.28 9.2 7.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 ETO14421.1 - 0.51 8.4 21.6 0.57 8.2 21.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2722 PF10846.8 ETO14421.1 - 0.72 8.7 10.9 0.81 8.6 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) PI3K_1B_p101 PF10486.9 ETO14421.1 - 0.82 7.4 7.4 0.86 7.3 7.4 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SAPS PF04499.15 ETO14421.1 - 1.2 7.9 9.3 1.2 7.8 9.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Paf1 PF03985.13 ETO14421.1 - 2 7.3 17.8 2.8 6.8 17.8 1.2 1 0 0 1 1 1 0 Paf1 FmiP_Thoc5 PF09766.9 ETO14421.1 - 2.4 7.4 10.1 2.8 7.1 10.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 SURF2 PF05477.11 ETO14421.1 - 3.5 7.3 13.2 4.6 6.9 13.2 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF4746 PF15928.5 ETO14421.1 - 3.5 7.0 13.7 4.5 6.6 13.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RRN3 PF05327.11 ETO14421.1 - 3.9 5.9 15.2 4.5 5.7 15.2 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SLC12 PF03522.15 ETO14421.1 - 6.4 5.7 7.2 8 5.4 7.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 TFIIF_alpha PF05793.12 ETO14421.1 - 8 4.9 26.1 9.4 4.7 26.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) THOC2_N PF16134.5 ETO14421.1 - 8.2 4.9 8.7 9.8 4.7 8.7 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Retinal PF15449.6 ETO14421.1 - 9 3.9 8.5 11 3.7 8.5 1.0 1 0 0 1 1 1 0 Retinal protein CdvA PF18822.1 ETO14423.1 - 0.35 10.7 7.0 3.8 7.4 1.0 2.4 2 0 0 2 2 2 0 CdvA-like coiled-coil domain DUF2981 PF11200.8 ETO14423.1 - 0.7 9.6 9.9 0.95 9.1 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) RRM_1 PF00076.22 ETO14424.1 - 0.0021 17.9 0.0 0.008 16.0 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FANCL_C PF11793.8 ETO14425.1 - 0.068 13.4 0.2 0.24 11.6 0.0 2.1 2 0 0 2 2 2 0 FANCL C-terminal domain DUF3350 PF11830.8 ETO14426.1 - 2.3 8.6 8.5 0.29 11.5 0.4 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3350) Nmad5 PF18757.1 ETO14427.1 - 0.022 14.9 1.9 0.022 14.9 1.9 3.1 1 1 2 3 3 3 0 Nucleotide modification associated domain 5 PhoU PF01895.19 ETO14427.1 - 0.95 10.0 6.4 6.6 7.3 0.5 2.7 2 1 0 2 2 2 0 PhoU domain DUF3492 PF11997.8 ETO14427.1 - 8.1 6.1 13.5 0.78 9.4 6.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) TRCF PF03461.15 ETO14428.1 - 0.0077 16.6 6.7 0.058 13.8 0.3 3.0 2 1 1 3 3 3 1 TRCF domain TGase_elicitor PF16683.5 ETO14428.1 - 0.044 12.6 0.2 0.065 12.0 0.2 1.3 1 0 0 1 1 1 0 Transglutaminase elicitor AMP-binding_C_2 PF14535.6 ETO14428.1 - 0.12 12.6 0.3 0.12 12.6 0.3 3.5 2 2 1 3 3 3 0 AMP-binding enzyme C-terminal domain FERM_N_2 PF18038.1 ETO14428.1 - 0.28 12.0 3.2 1.7 9.6 0.1 2.7 1 1 2 3 3 3 0 FERM N-terminal domain LOH1CR12 PF10158.9 ETO14428.1 - 0.33 11.0 11.0 0.3 11.1 2.0 3.0 1 1 2 3 3 3 0 Tumour suppressor protein GSH_synthase PF03199.15 ETO14428.1 - 0.5 10.8 9.3 11 6.5 6.1 3.4 2 1 0 2 2 2 0 Eukaryotic glutathione synthase YPEB PF14620.6 ETO14428.1 - 0.86 8.9 24.3 0.3 10.4 9.8 3.0 1 1 2 3 3 3 0 YpeB sporulation DUF5067 PF16729.5 ETO14428.1 - 1.5 8.8 13.3 0.11 12.4 3.4 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF5067) UCH PF00443.29 ETO14429.1 - 2.2e-35 122.4 1.1 3.3e-34 118.5 1.1 2.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO14429.1 - 3.3e-16 59.8 0.3 1.4e-15 57.7 0.3 2.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase GST_N_2 PF13409.6 ETO14430.1 - 0.11 12.9 0.1 0.22 11.9 0.0 1.7 1 1 1 2 2 2 0 Glutathione S-transferase, N-terminal domain H_PPase PF03030.16 ETO14431.1 - 1e-34 120.2 7.6 5.1e-28 98.1 2.4 2.1 2 0 0 2 2 2 2 Inorganic H+ pyrophosphatase GPDPase_memb PF10110.9 ETO14431.1 - 0.0041 16.0 0.0 0.0054 15.5 0.0 1.1 1 0 0 1 1 1 1 Membrane domain of glycerophosphoryl diester phosphodiesterase DUF2157 PF09925.9 ETO14431.1 - 0.0072 16.1 0.4 0.0085 15.9 0.4 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2157) DUF2759 PF10958.8 ETO14431.1 - 0.0079 15.9 1.6 0.015 15.0 1.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2759) Ni_hydr_CYTB PF01292.20 ETO14431.1 - 0.014 15.0 0.2 0.017 14.7 0.2 1.2 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 H_PPase PF03030.16 ETO14432.1 - 1.9e-10 40.0 0.1 2.3e-10 39.8 0.1 1.0 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase PGF-CTERM PF18204.1 ETO14432.1 - 8.7 6.5 7.3 2.3 8.3 2.8 2.2 2 0 0 2 2 2 0 PGF-CTERM motif H_PPase PF03030.16 ETO14433.1 - 6.2e-82 276.3 11.0 6e-81 273.0 11.0 2.0 1 1 0 1 1 1 1 Inorganic H+ pyrophosphatase Phage_holin_3_6 PF07332.11 ETO14433.1 - 0.01 15.9 0.0 0.01 15.9 0.0 3.3 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III L6_membrane PF05805.12 ETO14433.1 - 0.5 9.9 6.6 0.26 10.8 0.2 2.2 1 1 1 2 2 2 0 L6 membrane protein DUF3522 PF12036.8 ETO14433.1 - 2.6 8.3 6.9 6.6 7.0 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3522) RhoGAP PF00620.27 ETO14434.1 - 6.9e-17 61.7 1.1 1.8e-16 60.3 0.1 2.3 2 0 0 2 2 2 1 RhoGAP domain LRR_6 PF13516.6 ETO14434.1 - 1.5e-06 27.8 20.5 0.0039 17.1 0.3 6.9 7 0 0 7 7 7 3 Leucine Rich repeat LRR_1 PF00560.33 ETO14434.1 - 2 9.3 0.0 2 9.3 0.0 6.8 7 1 0 7 7 7 0 Leucine Rich Repeat CDC45 PF02724.14 ETO14434.1 - 5.5 5.1 17.4 8.6 4.5 17.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Ecl1 PF12855.7 ETO14434.1 - 7.9 7.6 21.9 7 7.8 5.0 2.5 2 0 0 2 2 2 0 ECL1/2/3 zinc binding proteins Cpn60_TCP1 PF00118.24 ETO14435.1 - 1.3e-55 189.0 2.0 9.7e-44 149.8 0.1 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 ETO14436.1 - 1.3e-70 238.4 2.1 1.5e-70 238.2 2.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Rad60-SLD PF11976.8 ETO14437.1 - 9.1e-16 57.5 0.0 1.4e-15 56.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETO14437.1 - 6.1e-07 29.1 0.0 8.8e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family CEP19 PF14933.6 ETO14437.1 - 0.028 14.7 0.1 0.037 14.3 0.1 1.1 1 0 0 1 1 1 0 CEP19-like protein STAG PF08514.11 ETO14438.1 - 0.01 15.8 1.6 0.046 13.6 0.1 2.7 3 0 0 3 3 3 0 STAG domain Med25_VWA PF11265.8 ETO14438.1 - 0.035 13.9 0.0 7.9 6.2 0.0 2.3 2 0 0 2 2 2 0 Mediator complex subunit 25 von Willebrand factor type A RNA_helicase PF00910.22 ETO14438.1 - 0.087 13.2 0.3 32 5.0 0.0 3.5 4 0 0 4 4 4 0 RNA helicase ASC PF00858.24 ETO14439.1 - 0.14 11.1 8.1 0.16 10.9 8.1 1.2 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Hid1 PF12722.7 ETO14439.1 - 0.98 7.5 14.2 1.1 7.3 14.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CCD48 PF15799.5 ETO14439.1 - 3.5 5.8 10.2 5.4 5.2 10.3 1.2 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 Borrelia_P83 PF05262.11 ETO14439.1 - 7.1 5.0 20.7 7.1 5.0 20.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Peptidase_U57 PF05582.12 ETO14439.1 - 7.2 5.8 16.4 7.4 5.7 15.5 1.5 1 1 0 1 1 1 0 YabG peptidase U57 ALMT PF11744.8 ETO14439.1 - 8 5.2 15.9 11 4.8 15.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter V_ATPase_I PF01496.19 ETO14439.1 - 8.3 4.2 14.6 8.5 4.1 14.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nop14 PF04147.12 ETO14440.1 - 0.015 13.6 27.0 0.015 13.6 27.0 1.0 1 0 0 1 1 1 0 Nop14-like family DUF853 PF05872.12 ETO14440.1 - 0.053 12.1 1.7 0.055 12.1 1.7 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) CENP-N PF05238.13 ETO14440.1 - 1.3 8.2 8.2 1.8 7.8 8.2 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like DUF3292 PF11696.8 ETO14440.1 - 3.6 5.9 8.9 4.6 5.5 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) Peptidase_C78 PF07910.13 ETO14442.1 - 2.2e-06 27.3 0.2 2.2e-06 27.3 0.2 2.0 2 0 0 2 2 2 1 Peptidase family C78 ETRAMP PF09716.10 ETO14442.1 - 3.9e-05 23.6 8.5 0.0043 17.1 9.5 2.6 2 1 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) Peptidase_C54 PF03416.19 ETO14442.1 - 0.021 14.3 0.8 0.05 13.0 0.5 1.8 1 1 1 2 2 2 0 Peptidase family C54 Neur_chan_memb PF02932.16 ETO14442.1 - 0.05 13.6 0.2 0.08 13.0 0.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region zf-C2H2_4 PF13894.6 ETO14442.1 - 0.059 14.2 0.5 0.059 14.2 0.5 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Shisa PF13908.6 ETO14442.1 - 0.093 13.0 0.5 0.21 11.8 0.2 1.8 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator HisK_sensor PF18698.1 ETO14442.1 - 0.83 10.0 8.4 0.052 13.9 1.7 2.4 3 0 0 3 3 3 0 Histidine kinase sensor domain TPR_MLP1_2 PF07926.12 ETO14443.1 - 0.035 14.2 10.8 0.033 14.2 9.6 1.5 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4144 PF13642.6 ETO14443.1 - 0.037 14.6 1.8 0.11 13.1 0.1 2.1 2 0 0 2 2 2 0 protein structure with unknown function ATG16 PF08614.11 ETO14443.1 - 0.06 13.6 11.0 0.13 12.4 11.0 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) FlxA PF14282.6 ETO14443.1 - 0.28 11.2 7.4 0.45 10.5 6.3 2.0 1 1 0 1 1 1 0 FlxA-like protein DUF745 PF05335.13 ETO14443.1 - 0.45 10.2 3.3 0.64 9.7 3.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Nup54 PF13874.6 ETO14443.1 - 0.58 10.3 8.1 0.78 9.8 8.1 1.3 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 DUF4140 PF13600.6 ETO14443.1 - 1.1 9.8 3.9 2 8.9 0.1 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DivIC PF04977.15 ETO14443.1 - 7.5 6.4 10.0 2.5 7.9 1.7 2.7 1 1 1 2 2 2 0 Septum formation initiator Kelch_1 PF01344.25 ETO14444.1 - 2e-07 30.5 2.6 0.00015 21.2 0.6 4.2 4 1 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO14444.1 - 6.4e-07 29.4 5.2 0.21 12.0 0.2 4.9 5 1 1 6 6 6 2 Kelch motif Kelch_5 PF13854.6 ETO14444.1 - 1.9e-06 27.7 0.4 0.035 14.1 0.5 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO14444.1 - 8.6e-06 25.9 0.2 8.6e-05 22.7 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14444.1 - 9.9e-05 22.2 2.2 0.21 11.6 0.1 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO14444.1 - 0.0086 16.1 0.1 0.53 10.3 0.1 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain EF-hand_4 PF12763.7 ETO14445.1 - 1.1e-06 28.5 0.0 2.4e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 ETO14445.1 - 0.0012 18.3 0.1 0.0026 17.2 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO14445.1 - 0.0025 18.2 0.3 0.0051 17.2 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO14445.1 - 0.025 14.1 0.1 0.12 12.0 0.1 2.2 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 ETO14445.1 - 0.053 13.5 0.5 0.48 10.5 0.3 2.5 1 1 1 2 2 2 0 EF-hand domain WD40 PF00400.32 ETO14446.1 - 5.3e-86 280.3 49.9 2.9e-08 34.2 0.1 14.8 14 1 1 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14446.1 - 2.5e-20 72.6 22.1 0.023 15.0 0.1 11.3 1 1 12 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO14446.1 - 3.1e-15 56.3 24.1 0.0003 20.2 0.3 6.6 4 1 2 6 6 6 5 WD40-like domain SGL PF08450.12 ETO14446.1 - 0.015 14.9 0.2 1.4 8.5 0.0 3.5 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 ETO14446.1 - 0.06 13.3 8.0 5.1 7.2 0.0 5.8 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Beta_helix_2 PF18835.1 ETO14446.1 - 1.4 8.7 3.3 27 4.6 0.1 3.8 3 0 0 3 3 3 0 Beta helix repeat of Inulin fructotransferase ubiquitin PF00240.23 ETO14454.1 - 1.3e-10 40.9 1.6 1.9e-10 40.3 0.5 1.9 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD_2 PF13881.6 ETO14454.1 - 3.1e-05 24.0 0.2 0.00011 22.3 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO14454.1 - 0.00015 22.3 2.3 0.00024 21.6 0.2 2.3 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO14454.1 - 0.015 15.3 0.1 0.091 12.8 0.0 2.4 1 1 1 2 2 2 0 Ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO14454.1 - 0.031 14.6 0.3 0.031 14.6 0.3 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain PI3K_p85B PF02192.16 ETO14454.1 - 0.058 13.1 0.2 2.7 7.8 0.1 2.7 2 0 0 2 2 2 0 PI3-kinase family, p85-binding domain Rad60-SLD PF11976.8 ETO14454.1 - 1.2 9.0 5.6 0.21 11.4 0.3 2.5 2 1 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like DUF3091 PF11291.8 ETO14455.1 - 0.1 12.8 3.5 0.11 12.7 2.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) DEP PF00610.21 ETO14456.1 - 1.6e-34 117.8 1.8 2.2e-18 66.0 0.2 2.2 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF1229 PF06797.11 ETO14456.1 - 0.18 12.0 5.1 0.15 12.3 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1229) ADH_zinc_N PF00107.26 ETO14458.1 - 4.1e-22 78.5 0.0 6.5e-22 77.9 0.0 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO14458.1 - 9.9e-22 78.4 0.0 1.6e-21 77.7 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO14458.1 - 5.9e-07 29.3 0.1 1.1e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain PH PF00169.29 ETO14459.1 - 1.1e-12 48.4 7.7 2.7e-08 34.3 2.6 4.4 4 1 0 4 4 4 2 PH domain PH_2 PF08458.10 ETO14459.1 - 1.3e-07 31.9 0.5 0.0015 18.8 0.0 3.5 3 0 0 3 3 3 2 Plant pleckstrin homology-like region MBT PF02820.18 ETO14459.1 - 0.00015 22.0 0.0 0.00042 20.6 0.0 1.7 1 0 0 1 1 1 1 mbt repeat Tudor_4 PF18358.1 ETO14459.1 - 0.00056 19.4 2.6 0.0021 17.6 0.1 2.6 2 0 0 2 2 2 1 Histone methyltransferase Tudor domain PH_11 PF15413.6 ETO14459.1 - 0.011 16.1 3.4 15 6.1 2.5 3.9 2 1 0 2 2 2 0 Pleckstrin homology domain QH-AmDH_gamma PF08992.11 ETO14459.1 - 0.093 12.7 0.8 0.6 10.1 0.0 2.5 1 1 1 2 2 2 0 Quinohemoprotein amine dehydrogenase, gamma subunit Exonuc_VII_L PF02601.15 ETO14459.1 - 1 8.8 7.2 3.6 7.1 7.2 1.9 1 0 0 1 1 1 0 Exonuclease VII, large subunit PKcGMP_CC PF16808.5 ETO14459.1 - 1.2 9.0 7.4 1.5 8.8 1.0 2.8 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase RasGEF PF00617.19 ETO14461.1 - 1.5e-32 113.2 0.4 1.5e-32 113.2 0.4 2.0 2 0 0 2 2 2 1 RasGEF domain tRNA_lig_kinase PF08303.11 ETO14461.1 - 0.06 13.4 0.1 0.32 11.0 0.1 2.1 2 0 0 2 2 2 0 tRNA ligase kinase domain zf-BED PF02892.15 ETO14461.1 - 0.087 12.9 0.6 0.26 11.4 0.6 1.7 1 0 0 1 1 1 0 BED zinc finger Erf4 PF10256.9 ETO14461.1 - 0.72 10.0 4.2 4.7 7.3 0.1 3.2 2 2 1 3 3 3 0 Golgin subfamily A member 7/ERF4 family DUF4900 PF16241.5 ETO14462.1 - 0.15 12.4 0.1 0.37 11.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4900) Nop14 PF04147.12 ETO14462.1 - 0.27 9.4 30.0 0.43 8.7 30.0 1.3 1 0 0 1 1 1 0 Nop14-like family AF-4 PF05110.13 ETO14464.1 - 0.45 8.5 19.1 0.53 8.3 19.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF5523 PF17661.1 ETO14464.1 - 3.1 7.4 24.1 3.6 7.2 24.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) SLC12 PF03522.15 ETO14464.1 - 9.6 5.1 19.2 12 4.8 19.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TFIIA PF03153.13 ETO14465.1 - 0.00074 19.6 19.7 0.00095 19.3 19.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit SID-1_RNA_chan PF13965.6 ETO14465.1 - 0.17 10.3 5.1 0.21 9.9 5.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RNA_pol_Rpc4 PF05132.14 ETO14465.1 - 0.61 10.5 10.0 1.2 9.5 6.3 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Menin PF05053.13 ETO14465.1 - 2.2 6.5 16.1 3.1 6.0 16.1 1.1 1 0 0 1 1 1 0 Menin DUF1980 PF09323.10 ETO14465.1 - 3.4 7.6 5.5 7.2 6.5 5.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) RRM_1 PF00076.22 ETO14468.1 - 5.6e-07 29.3 0.0 1.3e-06 28.1 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO14469.1 - 4.1e-09 36.1 0.1 1e-08 34.8 0.1 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO14469.1 - 0.12 12.5 0.0 0.25 11.5 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif CDC37_C PF08564.10 ETO14471.1 - 8.7e-13 48.3 0.2 8.7e-13 48.3 0.2 2.3 2 0 0 2 2 2 1 Cdc37 C terminal domain CDC37_M PF08565.11 ETO14471.1 - 0.0028 17.5 0.3 0.0094 15.9 0.0 2.0 2 0 0 2 2 2 1 Cdc37 Hsp90 binding domain Med13_C PF06333.12 ETO14471.1 - 0.032 13.5 0.7 0.041 13.2 0.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain PSD2 PF07624.11 ETO14471.1 - 0.062 13.1 0.5 0.36 10.6 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1585) 7tm_2 PF00002.24 ETO14471.1 - 0.083 12.2 1.9 0.46 9.7 0.1 2.1 2 0 0 2 2 2 0 7 transmembrane receptor (Secretin family) UBM PF14377.6 ETO14471.1 - 0.18 11.3 0.7 2.2 7.9 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin binding region Presenilin PF01080.17 ETO14471.1 - 0.4 9.4 2.2 0.59 8.8 2.2 1.3 1 0 0 1 1 1 0 Presenilin DUF908 PF06012.12 ETO14471.1 - 1.4 8.3 5.4 2.3 7.6 5.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) PH_12 PF16457.5 ETO14471.1 - 1.4 9.5 4.4 2.2 8.8 1.8 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain TFIIE-A_C PF11521.8 ETO14471.1 - 2.6 8.4 7.7 14 6.0 1.5 3.3 3 0 0 3 3 3 0 C-terminal general transcription factor TFIIE alpha AIF_C PF14721.6 ETO14471.1 - 3.3 8.1 5.2 3 8.2 3.1 2.0 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF2052 PF09747.9 ETO14471.1 - 5.2 7.2 9.8 0.88 9.7 4.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Med3 PF11593.8 ETO14471.1 - 5.4 6.1 17.7 8.6 5.4 17.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DASH_Dad4 PF08650.10 ETO14471.1 - 6.9 6.7 6.8 35 4.5 1.7 3.6 4 0 0 4 4 4 0 DASH complex subunit Dad4 MGC-24 PF05283.11 ETO14471.1 - 7.5 7.0 11.9 17 5.8 11.9 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Gly_transf_sug PF04488.15 ETO14472.1 - 9e-13 48.7 0.3 3e-12 47.0 0.3 1.9 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ETO14472.1 - 0.0023 17.3 0.0 0.0056 16.1 0.0 1.7 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein O-antigen_lig PF13425.6 ETO14472.1 - 0.057 12.2 0.6 0.082 11.7 0.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4834 PF16118.5 ETO14472.1 - 0.061 14.3 0.0 0.23 12.4 0.0 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) NAM PF02365.15 ETO14474.1 - 2.1 9.3 8.7 0.57 11.1 4.3 2.1 2 2 0 2 2 2 0 No apical meristem (NAM) protein G-alpha PF00503.20 ETO14476.1 - 1.1e-39 136.6 10.9 5.2e-34 118.0 3.8 4.4 1 1 1 2 2 2 2 G-protein alpha subunit AAA_11 PF13086.6 ETO14476.1 - 0.014 15.2 2.3 0.022 14.5 2.3 1.2 1 0 0 1 1 1 0 AAA domain DUF2875 PF11394.8 ETO14477.1 - 0.029 13.2 0.0 0.038 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2875) Glyco_hydro_20 PF00728.22 ETO14478.1 - 2.9e-41 142.0 0.4 2.3e-40 139.1 0.4 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain Glycohydro_20b2 PF14845.6 ETO14479.1 - 6.8e-06 26.8 0.0 9.5e-06 26.3 0.0 1.2 1 0 0 1 1 1 1 beta-acetyl hexosaminidase like SR-25 PF10500.9 ETO14479.1 - 0.84 9.2 3.7 1 8.9 3.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Metallothio_Pro PF02069.16 ETO14481.1 - 0.047 13.9 1.9 0.78 10.0 0.7 2.7 2 0 0 2 2 2 0 Prokaryotic metallothionein Arm PF00514.23 ETO14482.1 - 2.6e-17 62.2 1.7 0.019 15.0 0.0 6.7 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat Arm_3 PF16186.5 ETO14482.1 - 0.00067 19.2 0.0 0.002 17.7 0.0 1.8 1 0 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 ETO14482.1 - 0.0017 18.9 0.1 8.6 7.0 0.0 3.4 3 0 0 3 3 3 2 HEAT-like repeat Pneumovirus_M2 PF06436.11 ETO14482.1 - 0.095 12.2 0.2 0.26 10.8 0.2 1.7 1 0 0 1 1 1 0 Pneumovirus matrix protein 2 (M2) IBB PF01749.20 ETO14483.1 - 2.5e-06 27.9 4.0 6e-06 26.6 4.0 1.6 1 1 0 1 1 1 1 Importin beta binding domain Mrpl_C PF18502.1 ETO14483.1 - 0.0033 17.7 0.8 0.0055 17.0 0.4 1.5 1 1 0 1 1 1 1 54S ribosomal protein L8 C-terminal domain Enterotoxin_HS1 PF08090.11 ETO14483.1 - 0.14 12.1 1.4 0.31 11.0 1.4 1.5 1 0 0 1 1 1 0 Heat stable E.coli enterotoxin 1 RhoGAP PF00620.27 ETO14484.1 - 8.2e-32 110.1 0.1 1.2e-31 109.6 0.1 1.2 1 0 0 1 1 1 1 RhoGAP domain Pkinase PF00069.25 ETO14485.1 - 1.8e-34 119.3 0.0 2.6e-34 118.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14485.1 - 4.8e-12 45.7 0.0 7.7e-12 45.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO14485.1 - 0.016 14.5 0.0 0.025 13.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Peptidase_S10 PF00450.22 ETO14486.1 - 1.2e-39 136.9 0.9 1.2e-39 136.9 0.9 2.2 2 0 0 2 2 2 2 Serine carboxypeptidase Rhodanese PF00581.20 ETO14486.1 - 2.4e-06 28.0 0.4 0.00023 21.7 0.1 2.5 2 0 0 2 2 2 2 Rhodanese-like domain ATR13 PF16829.5 ETO14488.1 - 0.078 13.3 0.7 0.18 12.1 0.2 1.9 2 0 0 2 2 2 0 Avirulence protein ATR13, RxLR effector DUF4404 PF14357.6 ETO14488.1 - 2.7 8.7 10.3 4.5 8.0 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) TIP120 PF08623.10 ETO14488.1 - 8.9 6.0 11.0 0.3 10.8 3.3 2.3 2 1 1 3 3 3 0 TATA-binding protein interacting (TIP20) BBS2_C PF14782.6 ETO14490.1 - 3.2e-105 352.4 2.1 5.4e-104 348.3 2.1 2.0 1 1 0 1 1 1 1 Ciliary BBSome complex subunit 2, C-terminal DUF1583 PF07622.11 ETO14490.1 - 0.015 14.0 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1583) BBS2_N PF14781.6 ETO14491.1 - 1.8e-30 104.9 0.3 4.4e-29 100.5 0.0 3.0 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, N-terminal BBS2_Mid PF14783.6 ETO14491.1 - 2.2e-25 88.8 6.3 6.3e-23 80.9 1.7 3.8 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Itfg2 PF15907.5 ETO14491.1 - 2.7e-08 33.2 0.9 5.4e-05 22.4 0.0 2.5 3 0 0 3 3 3 2 Integrin-alpha FG-GAP repeat-containing protein 2 BBS2_C PF14782.6 ETO14491.1 - 2.4e-07 29.9 0.2 4e-05 22.6 0.0 2.2 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, C-terminal VCBS PF13517.6 ETO14491.1 - 0.01 16.4 2.4 0.38 11.4 0.5 2.9 2 1 1 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PHTB1_N PF14727.6 ETO14491.1 - 0.014 14.8 1.5 0.79 9.0 0.0 2.8 3 1 0 3 3 3 0 PTHB1 N-terminus PQQ_2 PF13360.6 ETO14491.1 - 0.016 14.8 0.0 0.051 13.2 0.0 1.7 2 0 0 2 2 2 0 PQQ-like domain BBS1 PF14779.6 ETO14491.1 - 0.034 13.6 0.3 0.37 10.2 0.0 2.3 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 1 ANAPC4_WD40 PF12894.7 ETO14491.1 - 0.078 13.3 0.4 0.34 11.2 0.1 2.4 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO14491.1 - 0.17 12.8 0.5 1.5 9.9 0.1 2.7 2 0 0 2 2 2 0 WD domain, G-beta repeat BSD PF03909.17 ETO14492.1 - 0.0096 15.9 0.0 0.037 14.0 0.0 2.0 1 0 0 1 1 1 1 BSD domain DUF3537 PF12056.8 ETO14492.1 - 0.94 8.2 4.3 1.5 7.6 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) RMI1_N PF08585.12 ETO14493.1 - 3.7 7.2 10.4 0.068 12.9 1.5 2.1 1 1 0 2 2 2 0 RecQ mediated genome instability protein ELM2 PF01448.24 ETO14494.1 - 0.062 14.1 0.0 0.062 14.1 0.0 2.8 4 0 0 4 4 4 0 ELM2 domain XRN_M PF17846.1 ETO14496.1 - 3e-76 257.2 10.0 3.5e-56 191.0 0.5 3.2 3 0 0 3 3 3 2 Xrn1 helical domain XRN_N PF03159.18 ETO14496.1 - 7.4e-72 241.7 5.6 8.4e-72 241.5 0.0 2.4 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN1_D1 PF18332.1 ETO14496.1 - 3e-21 76.0 0.1 1.6e-20 73.7 0.0 2.3 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D1 domain SH3_12 PF18129.1 ETO14496.1 - 1.5e-19 69.8 0.4 6.7e-19 67.8 0.2 2.1 2 0 0 2 2 2 1 Xrn1 SH3-like domain XRN1_D2_D3 PF18334.1 ETO14496.1 - 0.0047 17.1 0.6 0.048 13.9 0.0 2.7 2 0 0 2 2 2 1 Exoribonuclease Xrn1 D2/D3 domain ANAPC15 PF15243.6 ETO14496.1 - 0.31 11.5 3.3 0.91 10.0 3.3 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 FMN_red PF03358.15 ETO14497.1 - 9.6e-10 38.4 0.0 1.4e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ETO14497.1 - 0.0011 18.8 0.0 0.0014 18.4 0.0 1.2 1 0 0 1 1 1 1 Flavodoxin-like fold MFS_2 PF13347.6 ETO14498.1 - 8e-05 21.4 5.2 0.00011 20.9 0.5 2.5 2 1 0 2 2 2 1 MFS/sugar transport protein Renin_r PF07850.14 ETO14498.1 - 0.21 12.2 0.1 0.21 12.2 0.1 3.3 4 0 0 4 4 4 0 Renin receptor-like protein Torus PF16131.5 ETO14498.1 - 2.2 9.0 8.2 5.7 7.7 0.5 3.8 3 0 0 3 3 3 0 Torus domain EOS1 PF12326.8 ETO14498.1 - 2.5 8.0 13.0 0.62 10.0 0.1 3.8 3 1 0 3 3 3 0 N-glycosylation protein DUF456 PF04306.13 ETO14498.1 - 3.4 8.0 9.7 2.1 8.7 0.0 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF456) Connexin PF00029.19 ETO14498.1 - 9.7 5.9 11.7 11 5.7 0.5 3.7 3 1 0 3 3 3 0 Connexin zf-RAG1 PF10426.9 ETO14499.1 - 0.016 15.4 0.1 0.033 14.3 0.1 1.6 1 0 0 1 1 1 0 Recombination-activating protein 1 zinc-finger domain zf-RING_2 PF13639.6 ETO14499.1 - 5.2 7.5 15.9 0.6 10.5 8.6 2.7 2 1 1 3 3 3 0 Ring finger domain IBR PF01485.21 ETO14500.1 - 0.0045 17.2 11.0 0.23 11.7 1.4 2.5 1 1 1 2 2 2 2 IBR domain, a half RING-finger domain zf-RRPl_C4 PF17026.5 ETO14500.1 - 0.33 11.1 6.5 0.26 11.4 2.2 2.2 1 1 1 2 2 2 0 Putative ribonucleoprotein zinc-finger pf C4 type zf-like PF04071.12 ETO14500.1 - 0.94 9.4 0.1 0.94 9.4 0.1 3.1 1 1 2 3 3 3 0 Cysteine-rich small domain PHD PF00628.29 ETO14500.1 - 3.9 7.4 9.4 3.6 7.6 2.3 2.5 2 1 0 2 2 2 0 PHD-finger Ssl1 PF04056.14 ETO14501.1 - 1.9e-63 213.8 0.2 2.7e-63 213.3 0.2 1.2 1 0 0 1 1 1 1 Ssl1-like C1_4 PF07975.12 ETO14501.1 - 1.3e-11 44.5 13.6 1.3e-11 44.5 13.6 2.9 2 1 0 2 2 2 1 TFIIH C1-like domain VWA_2 PF13519.6 ETO14501.1 - 6.6e-07 29.9 0.0 1.2e-06 29.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain DZR PF12773.7 ETO14501.1 - 8.7e-05 22.5 11.6 0.0015 18.6 2.9 2.7 1 1 1 2 2 2 2 Double zinc ribbon IBR PF01485.21 ETO14501.1 - 0.0073 16.5 10.1 0.0073 16.5 10.1 2.8 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain VWA PF00092.28 ETO14501.1 - 0.049 13.9 0.1 0.083 13.1 0.1 1.3 1 0 0 1 1 1 0 von Willebrand factor type A domain GTP_EFTU PF00009.27 ETO14503.1 - 7.7e-32 110.4 0.0 2.2e-31 108.9 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain IF-2 PF11987.8 ETO14503.1 - 2.7e-17 62.8 0.2 9.6e-17 61.0 0.0 2.1 2 0 0 2 2 2 1 Translation-initiation factor 2 GTP_EFTU_D2 PF03144.25 ETO14503.1 - 4.1e-11 43.1 7.1 7.7e-07 29.4 0.0 3.5 3 0 0 3 3 3 2 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ETO14503.1 - 7.1e-11 41.9 0.9 1.6e-10 40.7 0.9 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 MMR_HSR1 PF01926.23 ETO14503.1 - 1e-06 28.8 0.0 3.9e-06 26.9 0.0 2.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ETO14503.1 - 0.0024 18.1 0.0 0.0068 16.6 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ETO14503.1 - 0.0037 17.5 0.0 0.012 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain ATP_bind_1 PF03029.17 ETO14503.1 - 0.045 13.5 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_16 PF13191.6 ETO14503.1 - 0.057 13.8 0.0 0.22 11.9 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain Pkinase PF00069.25 ETO14504.1 - 0.0011 18.4 3.7 0.28 10.5 2.6 2.7 2 1 0 2 2 2 1 Protein kinase domain Rrp44_CSD1 PF17216.3 ETO14504.1 - 0.29 10.8 5.0 0.55 9.9 5.0 1.5 1 0 0 1 1 1 0 Rrp44-like cold shock domain Pkinase PF00069.25 ETO14505.1 - 2.7e-16 59.7 0.1 3.2e-16 59.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14505.1 - 0.002 17.5 0.0 0.0025 17.2 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF2207 PF09972.9 ETO14505.1 - 0.0054 15.6 5.5 0.0065 15.3 5.5 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Cobalamin_bind PF01122.19 ETO14505.1 - 0.16 10.8 0.0 0.21 10.4 0.0 1.1 1 0 0 1 1 1 0 Eukaryotic cobalamin-binding protein FeoB_associated PF12669.7 ETO14505.1 - 4.6 7.7 6.5 11 6.6 6.5 1.6 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein EAP30 PF04157.16 ETO14507.1 - 1.1e-38 132.8 1.5 1.8e-38 132.2 1.5 1.2 1 0 0 1 1 1 1 EAP30/Vps36 family PheRS_DBD1 PF18552.1 ETO14507.1 - 0.091 12.5 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 PheRS DNA binding domain 1 Mod_r PF07200.13 ETO14508.1 - 0.0028 17.8 15.8 0.0028 17.8 15.8 9.1 2 2 4 7 7 7 2 Modifier of rudimentary (Mod(r)) protein TLE_N PF03920.15 ETO14508.1 - 0.0035 17.4 2.0 0.0035 17.4 2.0 8.0 5 5 2 8 8 8 1 Groucho/TLE N-terminal Q-rich domain FlaC_arch PF05377.11 ETO14508.1 - 0.044 14.2 0.4 0.044 14.2 0.4 12.3 9 4 5 14 14 14 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 ETO14508.1 - 2 9.0 144.8 0.35 11.4 10.7 8.8 1 1 8 9 9 9 0 Apg6 coiled-coil region Ribosomal_S7e PF01251.18 ETO14509.1 - 1.7e-53 181.1 6.3 3.2e-50 170.4 4.1 2.9 2 0 0 2 2 2 2 Ribosomal protein S7e TFIID-18kDa PF02269.16 ETO14509.1 - 3.6e-17 62.2 0.8 1.3e-16 60.4 0.2 2.3 2 0 0 2 2 2 1 Transcription initiation factor IID, 18kD subunit CDC45 PF02724.14 ETO14509.1 - 0.019 13.3 4.7 0.026 12.9 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein CBFD_NFYB_HMF PF00808.23 ETO14509.1 - 0.063 13.6 0.0 0.19 12.0 0.0 1.8 1 0 0 1 1 1 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone Neur_chan_memb PF02932.16 ETO14509.1 - 0.42 10.6 6.5 0.23 11.5 4.5 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO14509.1 - 0.82 8.8 3.6 1.2 8.3 3.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 ETO14509.1 - 1 8.0 16.3 0.042 12.6 9.2 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup SpoIIP PF07454.11 ETO14509.1 - 2.4 7.5 10.2 4.3 6.7 9.5 1.9 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 ETO14509.1 - 9.7 4.8 14.7 18 3.9 14.7 1.4 1 0 0 1 1 1 0 Presenilin Sulfotransfer_1 PF00685.27 ETO14510.1 - 0.00024 20.7 2.0 0.0037 16.8 1.9 2.1 1 1 0 1 1 1 1 Sulfotransferase domain DUF1077 PF06417.12 ETO14511.1 - 1.9e-36 124.6 2.5 3.9e-36 123.6 2.5 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1077) HlyIII PF03006.20 ETO14512.1 - 3.5e-08 33.4 20.3 4.3e-08 33.2 20.3 1.1 1 0 0 1 1 1 1 Haemolysin-III related Pkinase PF00069.25 ETO14513.1 - 4.5e-34 118.0 0.3 7.3e-28 97.7 0.1 2.5 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14513.1 - 9.5e-17 61.1 0.4 1.2e-15 57.5 0.1 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase FTA2 PF13095.6 ETO14513.1 - 0.052 13.2 0.1 1.4 8.5 0.0 2.7 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Peptidase_S64 PF08192.11 ETO14515.1 - 1.9 6.9 10.8 2.4 6.6 10.8 1.0 1 0 0 1 1 1 0 Peptidase family S64 PI3_PI4_kinase PF00454.27 ETO14516.1 - 2.5e-40 138.9 0.2 5.4e-39 134.5 0.2 2.4 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETO14516.1 - 2.6e-39 134.5 3.2 4.6e-39 133.7 3.2 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) NOA36 PF06524.12 ETO14516.1 - 0.81 9.0 4.4 1.5 8.1 4.4 1.4 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO14516.1 - 2.8 6.6 6.1 4.4 6.0 6.1 1.2 1 0 0 1 1 1 0 Presenilin Apc15p PF05841.11 ETO14516.1 - 7.6 7.4 22.0 21 5.9 22.0 1.7 1 0 0 1 1 1 0 Apc15p protein DUF1764 PF08576.10 ETO14517.1 - 0.019 15.8 20.2 0.023 15.6 20.2 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) TFB6 PF17110.5 ETO14517.1 - 0.1 12.3 8.7 0.13 12.0 8.7 1.0 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Peptidase_S49_N PF08496.10 ETO14517.1 - 0.11 12.6 23.4 0.12 12.4 23.4 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF3807 PF12720.7 ETO14517.1 - 0.18 12.1 15.4 0.19 12.0 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Eapp_C PF10238.9 ETO14517.1 - 0.37 10.9 9.6 0.43 10.6 9.6 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Vfa1 PF08432.10 ETO14517.1 - 0.72 10.2 22.2 0.8 10.0 22.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Pex26 PF07163.12 ETO14517.1 - 0.99 8.6 6.3 1 8.6 6.3 1.1 1 0 0 1 1 1 0 Pex26 protein EIIBC-GUT_N PF03612.14 ETO14517.1 - 1.1 9.0 10.9 1.2 8.8 10.9 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Folliculin PF11704.8 ETO14517.1 - 1.1 9.1 6.6 1.2 9.0 6.6 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport GNAT_acetyltr_2 PF13718.6 ETO14517.1 - 1.4 8.3 8.5 1.6 8.1 8.5 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Connexin PF00029.19 ETO14517.1 - 1.6 8.4 13.2 1.7 8.3 13.2 1.1 1 0 0 1 1 1 0 Connexin AAA_11 PF13086.6 ETO14517.1 - 1.6 8.5 14.3 1.8 8.3 14.3 1.0 1 0 0 1 1 1 0 AAA domain RR_TM4-6 PF06459.12 ETO14517.1 - 1.8 8.3 14.9 2 8.2 14.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 ETO14517.1 - 1.9 7.7 12.3 2.1 7.6 12.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Sec62 PF03839.16 ETO14517.1 - 2.1 7.8 17.1 2.3 7.7 17.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF1943 PF09172.11 ETO14517.1 - 2.6 7.2 14.0 2.6 7.2 14.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF3464 PF11947.8 ETO14517.1 - 2.7 7.7 15.2 3.1 7.5 15.2 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DDHD PF02862.17 ETO14517.1 - 2.8 8.1 6.8 2.9 8.0 6.8 1.1 1 0 0 1 1 1 0 DDHD domain LicD PF04991.13 ETO14517.1 - 3.2 7.8 15.8 3.6 7.6 15.8 1.0 1 0 0 1 1 1 0 LicD family XRN_M PF17846.1 ETO14517.1 - 3.6 6.4 12.7 4.3 6.2 12.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain DUF2828 PF11443.8 ETO14517.1 - 4.4 5.3 16.1 4.6 5.2 16.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) AAA_13 PF13166.6 ETO14517.1 - 4.5 5.8 19.1 4.8 5.7 19.1 1.0 1 0 0 1 1 1 0 AAA domain MecA PF05389.12 ETO14517.1 - 4.6 6.8 14.8 7.7 6.1 14.8 1.4 1 1 0 1 1 1 0 Negative regulator of genetic competence (MecA) CDC45 PF02724.14 ETO14517.1 - 4.8 5.3 14.9 4.9 5.3 14.9 1.0 1 0 0 1 1 1 0 CDC45-like protein GAGA_bind PF06217.12 ETO14517.1 - 5 7.3 21.4 5.4 7.2 21.4 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Presenilin PF01080.17 ETO14517.1 - 5.3 5.7 8.7 5.7 5.6 8.7 1.1 1 0 0 1 1 1 0 Presenilin MDFI PF15316.6 ETO14517.1 - 5.5 7.0 5.6 5.8 7.0 5.6 1.1 1 0 0 1 1 1 0 MyoD family inhibitor MMM1 PF10296.9 ETO14517.1 - 5.8 5.9 10.3 6.6 5.7 10.3 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Membralin PF09746.9 ETO14517.1 - 8.3 5.3 8.0 9.1 5.2 8.0 1.0 1 0 0 1 1 1 0 Tumour-associated protein OATP PF03137.20 ETO14517.1 - 8.8 4.5 8.3 9.1 4.4 8.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Folate_carrier PF01770.18 ETO14517.1 - 9.4 4.8 6.1 9.8 4.8 6.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier TFIIA PF03153.13 ETO14518.1 - 3.1 7.7 8.0 4.2 7.3 8.0 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RSN1_TM PF13967.6 ETO14519.1 - 0.0092 15.8 0.5 0.031 14.1 0.2 1.8 1 1 0 1 1 1 1 Late exocytosis, associated with Golgi transport Zip PF02535.22 ETO14519.1 - 0.31 10.2 2.5 0.51 9.5 2.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO14519.1 - 0.59 8.9 10.3 0.91 8.2 10.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pox_Ag35 PF03286.14 ETO14519.1 - 1 9.1 6.7 1.7 8.4 6.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein GalKase_gal_bdg PF10509.9 ETO14520.1 - 5.7e-22 77.0 0.0 9.8e-22 76.3 0.0 1.4 1 0 0 1 1 1 1 Galactokinase galactose-binding signature GHMP_kinases_N PF00288.26 ETO14520.1 - 1.5e-11 44.3 0.2 3.9e-11 43.0 0.2 1.8 1 0 0 1 1 1 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ETO14520.1 - 1.4e-08 35.0 0.0 4.2e-08 33.4 0.0 1.8 1 0 0 1 1 1 1 GHMP kinases C terminal DEP PF00610.21 ETO14524.1 - 6.1e-10 39.0 0.8 3.1e-09 36.7 0.8 2.2 1 1 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CAP_GLY PF01302.25 ETO14525.1 - 1.9e-17 63.1 0.1 3.7e-17 62.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain LRR_9 PF14580.6 ETO14525.1 - 2.7e-09 36.8 2.4 5.6e-07 29.2 0.2 3.0 3 0 0 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 ETO14525.1 - 9.5e-09 35.4 20.7 0.005 17.2 1.2 6.2 5 1 0 6 6 6 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO14525.1 - 4.8e-07 29.4 14.3 0.057 13.2 1.1 5.4 4 2 0 4 4 4 3 Leucine rich repeat Ubiquitin_2 PF14560.6 ETO14525.1 - 7.4e-07 29.5 0.1 2.4e-06 27.9 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin-like domain LRR_6 PF13516.6 ETO14525.1 - 0.045 13.8 3.5 0.88 9.8 0.0 3.8 4 0 0 4 4 4 0 Leucine Rich repeat LRR_1 PF00560.33 ETO14525.1 - 6.6 7.7 18.2 14 6.7 0.0 6.1 6 0 0 6 6 6 0 Leucine Rich Repeat DUF2369 PF10179.9 ETO14526.1 - 2.8 8.4 8.2 0.59 10.5 3.6 2.4 2 1 0 2 2 2 0 Uncharacterised conserved protein (DUF2369) fn3 PF00041.21 ETO14527.1 - 8.1e-13 48.5 0.0 0.048 14.0 0.0 4.4 4 0 0 4 4 4 4 Fibronectin type III domain SRP-alpha_N PF04086.13 ETO14527.1 - 2.1 8.2 12.9 4.6 7.1 12.8 1.5 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal PDZ PF00595.24 ETO14528.1 - 3.1e-06 27.5 0.1 8.3e-06 26.1 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO14528.1 - 0.004 17.0 0.1 0.0077 16.1 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO14528.1 - 0.0086 16.4 0.1 0.019 15.3 0.1 1.5 1 0 0 1 1 1 1 PDZ domain 2OG-FeII_Oxy_2 PF13532.6 ETO14529.1 - 3.5e-11 43.6 0.0 4.8e-11 43.2 0.0 1.2 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RhoGEF PF00621.20 ETO14531.1 - 7.6e-16 58.9 2.6 1.1e-15 58.3 2.6 1.2 1 0 0 1 1 1 1 RhoGEF domain Prok-RING_1 PF14446.6 ETO14531.1 - 0.2 11.6 0.9 2.1 8.3 0.2 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 FAM176 PF14851.6 ETO14533.1 - 2.1 8.0 5.6 0.87 9.2 0.6 2.5 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 ETO14533.1 - 6.9 7.1 14.8 18 5.8 7.9 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Pkinase PF00069.25 ETO14534.1 - 2e-08 33.9 0.0 3.5e-08 33.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain KASH_CCD PF14662.6 ETO14535.1 - 0.002 18.0 15.1 0.0054 16.6 7.2 2.1 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH Cnn_1N PF07989.11 ETO14535.1 - 0.0044 17.1 10.2 0.0091 16.1 4.0 2.8 3 0 0 3 3 3 1 Centrosomin N-terminal motif 1 Tropomyosin_1 PF12718.7 ETO14535.1 - 0.0064 16.7 7.3 0.0064 16.7 7.3 2.1 2 0 0 2 2 2 1 Tropomyosin like Lzipper-MIP1 PF14389.6 ETO14535.1 - 0.014 15.7 0.7 0.014 15.7 0.7 2.8 3 1 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 Snapin_Pallidin PF14712.6 ETO14535.1 - 0.038 14.4 3.7 0.038 14.4 3.7 2.2 2 0 0 2 2 2 0 Snapin/Pallidin MAD PF05557.13 ETO14535.1 - 0.051 11.9 11.0 0.56 8.5 0.1 2.0 2 0 0 2 2 2 0 Mitotic checkpoint protein DUF2681 PF10883.8 ETO14535.1 - 0.053 13.9 2.2 2.3 8.7 1.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF496 PF04363.12 ETO14535.1 - 0.054 13.5 4.6 0.083 12.9 2.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF496) ADIP PF11559.8 ETO14535.1 - 0.11 12.6 7.4 0.037 14.1 3.6 1.9 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Cep57_CLD PF14073.6 ETO14535.1 - 0.12 12.4 9.3 0.28 11.2 4.7 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Mod_r PF07200.13 ETO14535.1 - 0.15 12.2 8.2 0.029 14.5 2.6 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Fmp27_WPPW PF10359.9 ETO14535.1 - 0.16 10.8 7.2 0.062 12.1 4.9 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain ZapB PF06005.12 ETO14535.1 - 0.44 11.0 14.9 0.74 10.3 7.6 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Sec2p PF06428.11 ETO14535.1 - 0.52 10.3 8.0 0.48 10.4 3.2 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p Jnk-SapK_ap_N PF09744.9 ETO14535.1 - 0.52 10.5 10.8 0.11 12.8 5.5 1.9 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 ETO14535.1 - 0.53 10.1 9.0 3.4 7.5 2.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF724) KLRAQ PF10205.9 ETO14535.1 - 0.69 10.2 7.4 0.19 12.0 3.2 2.0 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein DUF1664 PF07889.12 ETO14535.1 - 1 9.4 5.3 0.3 11.1 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Csm1_N PF18504.1 ETO14535.1 - 1.1 9.7 9.0 7.3 7.0 1.5 2.7 2 1 1 3 3 3 0 Csm1 N-terminal domain Tropomyosin PF00261.20 ETO14535.1 - 1.2 8.5 11.8 0.15 11.4 4.4 2.1 2 0 0 2 2 2 0 Tropomyosin TMF_DNA_bd PF12329.8 ETO14535.1 - 1.7 8.7 13.5 2.4 8.2 5.2 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CHD5 PF04420.14 ETO14535.1 - 3 7.7 5.7 3.3 7.5 0.4 2.3 2 1 0 2 2 2 0 CHD5-like protein ATG16 PF08614.11 ETO14535.1 - 4.7 7.4 12.4 15 5.7 7.3 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BST2 PF16716.5 ETO14535.1 - 5.2 7.7 8.5 0.85 10.2 3.4 2.1 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 Fib_alpha PF08702.10 ETO14535.1 - 5.3 7.2 7.5 35 4.6 7.3 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family bZIP_1 PF00170.21 ETO14535.1 - 5.6 7.2 11.7 0.95 9.6 0.8 3.0 2 1 1 3 3 3 0 bZIP transcription factor HECT PF00632.25 ETO14536.1 - 4.7e-61 207.0 0.1 7.5e-61 206.3 0.1 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ETO14536.1 - 2.9e-14 53.2 1.0 7.1e-14 51.9 1.0 1.7 1 0 0 1 1 1 1 SPRY domain Sporozoite_P67 PF05642.11 ETO14537.1 - 0.013 13.6 11.0 0.016 13.4 3.3 2.0 1 1 1 2 2 2 0 Sporozoite P67 surface antigen RIFIN PF02009.16 ETO14537.1 - 0.12 12.2 6.9 0.14 12.1 6.9 1.1 1 0 0 1 1 1 0 Rifin DUF3807 PF12720.7 ETO14537.1 - 0.39 11.0 10.8 1 9.6 10.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3807) Macoilin PF09726.9 ETO14537.1 - 4.8 5.6 13.0 5.3 5.5 13.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF3439 PF11921.8 ETO14537.1 - 6.8 6.7 12.8 13 5.8 12.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MT PF12777.7 ETO14538.1 - 1.6e-09 37.3 10.5 3.3e-09 36.2 10.5 1.4 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor GEMIN8 PF15348.6 ETO14538.1 - 1.8 8.8 9.3 0.79 10.0 4.9 2.4 2 1 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 WD40 PF00400.32 ETO14539.1 - 4.2e-37 125.5 23.5 6.6e-07 29.9 1.5 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14539.1 - 3.6e-12 46.4 1.2 0.15 12.3 0.0 5.7 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14539.1 - 6.9e-12 44.8 4.5 0.0068 15.1 0.0 5.8 4 2 0 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO14539.1 - 9.4e-09 35.0 3.4 0.0013 18.1 0.1 5.7 2 2 2 5 5 5 2 WD40-like domain SH3_13 PF18335.1 ETO14539.1 - 0.025 14.4 2.1 9.7 6.1 0.0 3.6 3 0 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain WD40 PF00400.32 ETO14540.1 - 2.7e-32 110.3 32.2 1.7e-07 31.8 1.7 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14540.1 - 1.7e-09 37.8 0.1 0.1 12.9 0.0 4.2 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14540.1 - 3.7e-08 32.5 2.2 0.00039 19.2 1.7 3.3 3 1 0 3 3 3 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO14540.1 - 3.1e-05 24.0 0.9 0.06 13.4 0.0 4.5 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ETO14540.1 - 0.0034 16.8 4.9 0.023 14.0 0.3 3.8 2 2 2 5 5 5 1 WD40-like domain DUF3611 PF12263.8 ETO14541.1 - 0.042 13.7 0.0 0.079 12.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3611) WD40 PF00400.32 ETO14542.1 - 1.8e-59 196.3 15.8 5.6e-10 39.7 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14542.1 - 8.4e-18 64.5 6.6 0.0014 18.9 0.3 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14542.1 - 1.8e-12 46.7 8.2 0.014 14.1 0.0 5.5 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO14542.1 - 1e-09 37.8 5.9 0.069 12.1 0.0 5.2 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ETO14542.1 - 4.4e-08 32.7 0.0 2.8 8.0 0.0 4.7 4 0 0 4 4 4 4 PQQ enzyme repeat WD40_like PF17005.5 ETO14542.1 - 6.4e-08 32.3 3.1 0.0018 17.7 0.0 3.5 1 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO14542.1 - 1e-05 24.3 0.6 0.0012 17.5 0.0 2.9 2 2 1 3 3 3 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO14542.1 - 0.00024 20.1 4.8 0.92 8.4 0.1 4.1 1 1 3 5 5 5 2 Partner and localizer of BRCA2 WD40 domain Srg PF02118.21 ETO14543.1 - 0.03 14.0 0.1 0.044 13.4 0.1 1.2 1 0 0 1 1 1 0 Srg family chemoreceptor CAP_GLY PF01302.25 ETO14543.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.6 1 1 0 1 1 1 0 CAP-Gly domain Cas_Cas2CT1978 PF09707.10 ETO14544.1 - 0.044 13.9 0.1 0.087 12.9 0.0 1.6 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas2CT1978) Rrp15p PF07890.12 ETO14545.1 - 0.015 15.7 0.9 0.029 14.7 0.9 1.4 1 0 0 1 1 1 0 Rrp15p RGS PF00615.19 ETO14545.1 - 0.026 14.8 2.9 0.27 11.5 2.9 2.5 1 1 0 1 1 1 0 Regulator of G protein signaling domain DUF809 PF05663.11 ETO14545.1 - 0.028 14.6 7.3 0.032 14.4 0.7 3.0 1 1 1 2 2 2 0 Protein of unknown function (DUF809) FAM176 PF14851.6 ETO14545.1 - 0.065 12.9 4.0 1.1 8.9 2.8 2.4 2 0 0 2 2 2 0 FAM176 family EI24 PF07264.11 ETO14545.1 - 0.52 10.5 15.5 0.2 11.9 1.9 2.8 2 0 0 2 2 2 0 Etoposide-induced protein 2.4 (EI24) TLP-20 PF06088.11 ETO14545.1 - 0.53 10.2 3.1 1.8 8.4 3.1 1.9 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Ras PF00071.22 ETO14546.1 - 3.5e-23 82.0 0.2 5.7e-23 81.3 0.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO14546.1 - 6.8e-11 42.4 0.0 1.2e-10 41.6 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO14546.1 - 0.013 14.9 0.0 0.023 14.2 0.0 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family DLIC PF05783.11 ETO14546.1 - 0.046 12.5 0.1 0.071 11.9 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) Transformer PF06495.11 ETO14547.1 - 0.0045 17.1 15.2 0.0067 16.6 15.2 1.2 1 0 0 1 1 1 1 Fruit fly transformer protein Corona_nucleoca PF00937.18 ETO14547.1 - 0.011 14.8 5.6 0.014 14.5 5.6 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein SR-25 PF10500.9 ETO14547.1 - 0.37 10.4 16.5 0.5 10.0 16.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Uds1 PF15456.6 ETO14547.1 - 4.1 7.6 9.6 4.8 7.4 8.6 1.5 1 1 0 1 1 1 0 Up-regulated During Septation DUF4614 PF15391.6 ETO14547.1 - 4.9 7.1 12.7 7 6.6 12.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Apt1 PF10351.9 ETO14547.1 - 5.2 5.8 11.2 6.6 5.5 11.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Atrophin-1 PF03154.15 ETO14548.1 - 0.00022 19.7 12.9 0.00028 19.4 12.9 1.1 1 0 0 1 1 1 1 Atrophin-1 family SelP_N PF04592.14 ETO14548.1 - 0.0017 17.8 14.3 0.0027 17.2 14.3 1.3 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Dynactin_p62 PF05502.13 ETO14548.1 - 0.0081 15.0 6.4 0.009 14.8 6.4 1.1 1 0 0 1 1 1 1 Dynactin p62 family DUF3304 PF11745.8 ETO14548.1 - 0.0099 16.3 0.8 0.015 15.7 0.8 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3304) GNAT_acetyltr_2 PF13718.6 ETO14548.1 - 0.011 15.2 4.6 0.013 14.9 4.6 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Folate_carrier PF01770.18 ETO14548.1 - 0.017 13.9 1.1 0.019 13.8 1.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF913 PF06025.12 ETO14548.1 - 0.024 13.6 3.3 0.025 13.6 3.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Cytomega_UL84 PF06284.11 ETO14548.1 - 0.03 12.8 5.0 0.03 12.8 5.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DDHD PF02862.17 ETO14548.1 - 0.059 13.5 3.8 0.063 13.4 3.8 1.2 1 0 0 1 1 1 0 DDHD domain Trypan_PARP PF05887.11 ETO14548.1 - 0.079 12.9 7.4 0.11 12.5 7.4 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PAT1 PF09770.9 ETO14548.1 - 0.081 11.2 7.2 0.088 11.1 7.2 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 ETO14548.1 - 0.089 11.5 7.6 0.088 11.6 7.6 1.1 1 0 0 1 1 1 0 Presenilin CPSF100_C PF13299.6 ETO14548.1 - 0.093 12.9 7.1 0.11 12.7 7.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 ETO14548.1 - 0.13 12.7 9.8 0.19 12.2 9.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Tim54 PF11711.8 ETO14548.1 - 0.13 11.0 9.3 0.15 10.8 9.3 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 O-antigen_lig PF13425.6 ETO14548.1 - 0.15 10.8 2.4 0.16 10.8 2.4 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF3537 PF12056.8 ETO14548.1 - 0.16 10.7 2.2 0.19 10.5 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) FAM176 PF14851.6 ETO14548.1 - 0.17 11.5 9.4 0.23 11.1 9.4 1.3 1 0 0 1 1 1 0 FAM176 family NPR3 PF03666.13 ETO14548.1 - 0.19 10.5 9.7 0.19 10.5 9.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AAT PF03417.16 ETO14548.1 - 0.21 11.2 3.5 0.25 11.0 3.5 1.1 1 0 0 1 1 1 0 Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase Connexin PF00029.19 ETO14548.1 - 0.23 11.2 9.7 0.29 10.9 9.7 1.2 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 ETO14548.1 - 0.27 11.0 14.5 0.32 10.8 14.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4770 PF15994.5 ETO14548.1 - 0.29 11.4 8.2 0.34 11.1 8.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) RPA43_OB PF17875.1 ETO14548.1 - 0.33 11.6 6.7 0.58 10.8 6.6 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I CDC45 PF02724.14 ETO14548.1 - 0.51 8.6 16.0 0.55 8.5 16.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO14548.1 - 0.52 9.5 13.2 0.6 9.3 13.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.16 ETO14548.1 - 0.6 9.3 5.9 0.71 9.0 5.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NEMP PF10225.9 ETO14548.1 - 0.62 9.7 1.8 0.67 9.6 1.8 1.2 1 0 0 1 1 1 0 NEMP family DUF3915 PF13054.6 ETO14548.1 - 0.69 9.9 16.9 1.8 8.5 16.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) OATP PF03137.20 ETO14548.1 - 0.7 8.1 5.7 0.82 7.9 5.7 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Nucleoside_tran PF01733.18 ETO14548.1 - 0.77 9.1 2.6 1 8.6 2.6 1.3 1 0 0 1 1 1 0 Nucleoside transporter RRN3 PF05327.11 ETO14548.1 - 0.88 8.0 9.4 0.99 7.9 9.4 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CLN3 PF02487.17 ETO14548.1 - 0.88 8.5 4.9 1 8.4 4.9 1.1 1 0 0 1 1 1 0 CLN3 protein Serinc PF03348.15 ETO14548.1 - 1.2 8.0 3.0 1.4 7.8 3.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) CobT PF06213.12 ETO14548.1 - 1.4 8.2 13.8 1.8 7.9 13.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sec62 PF03839.16 ETO14548.1 - 1.5 8.2 13.8 1.8 8.0 13.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 ETO14548.1 - 1.7 7.4 8.6 1.8 7.3 8.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Cellulose_synt PF03552.14 ETO14548.1 - 1.8 6.9 5.3 1.8 6.9 5.3 1.0 1 0 0 1 1 1 0 Cellulose synthase Ureide_permease PF07168.11 ETO14548.1 - 2.3 6.9 4.0 2.5 6.8 4.0 1.2 1 0 0 1 1 1 0 Ureide permease TFB6 PF17110.5 ETO14548.1 - 2.8 7.7 7.7 4 7.2 7.7 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Paramyxo_ncap PF00973.19 ETO14548.1 - 2.9 6.7 8.6 3.2 6.6 8.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein V_ATPase_I PF01496.19 ETO14548.1 - 3.2 5.6 11.4 3.6 5.4 11.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3128 PF11326.8 ETO14548.1 - 4.4 7.7 10.5 5.1 7.5 9.5 1.7 2 0 0 2 2 1 0 Protein of unknown function (DUF3128) DUF4337 PF14235.6 ETO14548.1 - 5.4 7.1 7.5 7.3 6.7 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) YqfQ PF14181.6 ETO14548.1 - 6.2 7.0 10.7 8.9 6.5 10.7 1.3 1 0 0 1 1 1 0 YqfQ-like protein EIIBC-GUT_N PF03612.14 ETO14548.1 - 7.3 6.3 8.8 9.4 5.9 8.8 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3464 PF11947.8 ETO14548.1 - 7.3 6.3 11.0 11 5.8 11.0 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Vma12 PF11712.8 ETO14548.1 - 7.4 6.6 6.7 9.9 6.2 6.7 1.1 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase G0-G1_switch_2 PF15103.6 ETO14548.1 - 9.8 6.7 9.5 17 5.9 9.5 1.4 1 0 0 1 1 1 0 G0/G1 switch protein 2 WD40 PF00400.32 ETO14549.1 - 4.2e-142 457.8 66.2 4.3e-11 43.2 0.1 14.9 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14549.1 - 7e-40 135.2 13.8 0.014 15.7 0.0 13.1 1 1 12 13 13 13 13 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14549.1 - 1.2e-19 70.5 16.0 0.015 14.3 0.0 12.6 1 1 12 13 13 13 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14549.1 - 9.8e-15 54.6 23.0 0.18 11.1 0.0 9.0 7 2 2 10 10 9 6 WD40-like domain NACHT PF05729.12 ETO14549.1 - 3.2e-10 40.2 0.0 6e-10 39.3 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO14549.1 - 0.00013 21.5 4.8 0.0021 17.7 0.7 1.9 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO14549.1 - 0.0017 18.9 0.0 0.0017 18.9 0.0 3.4 3 0 0 3 3 3 1 AAA domain DUF5570 PF17731.1 ETO14549.1 - 0.0065 16.6 31.2 0.81 9.8 1.7 8.4 2 2 8 10 10 10 1 Family of unknown function (DUF5570) AAA_22 PF13401.6 ETO14549.1 - 0.0078 16.5 0.0 0.042 14.1 0.0 2.4 2 0 0 2 2 2 1 AAA domain Pentapeptide_4 PF13599.6 ETO14549.1 - 0.011 15.9 0.3 0.041 14.1 0.3 2.0 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) RsgA_GTPase PF03193.16 ETO14549.1 - 0.063 13.2 0.1 0.25 11.2 0.1 2.1 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 ETO14549.1 - 0.11 12.5 0.1 0.51 10.3 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE CUE PF02845.16 ETO14549.1 - 0.17 11.6 1.4 17 5.3 0.2 2.9 2 0 0 2 2 2 0 CUE domain PD40 PF07676.12 ETO14549.1 - 1.6 8.8 24.6 68 3.6 0.0 9.9 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat GAIN_A PF18619.1 ETO14549.1 - 3.6 7.9 7.5 28 5.0 0.0 5.6 7 0 0 7 7 6 0 GPCR-Autoproteolysis-INducing (GAIN) subdomain A WD40 PF00400.32 ETO14550.1 - 2.6e-60 198.9 16.0 1.3e-09 38.5 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14550.1 - 5.4e-17 61.9 7.8 0.00077 19.7 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO14550.1 - 1.2e-06 28.1 6.4 0.0011 18.3 0.2 4.0 1 1 4 5 5 5 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO14550.1 - 0.00012 20.7 0.3 0.22 10.0 0.0 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO14550.1 - 0.0013 18.6 0.0 11 6.1 0.0 4.4 4 0 0 4 4 4 1 PQQ enzyme repeat HPS6 PF15702.5 ETO14550.1 - 0.0015 16.7 0.0 0.24 9.4 0.0 3.1 3 1 1 4 4 4 1 Hermansky-Pudlak syndrome 6 protein HTH_micro PF17007.5 ETO14550.1 - 0.0026 16.7 0.4 0.024 13.5 0.1 2.4 2 1 1 3 3 3 1 HTH-like DUF4221 PF13970.6 ETO14550.1 - 0.015 14.9 3.0 0.18 11.3 0.0 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4221) PALB2_WD40 PF16756.5 ETO14550.1 - 0.017 14.0 8.2 3.8 6.3 5.6 4.5 1 1 2 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO14550.1 - 0.021 14.8 1.5 79 3.4 0.0 4.9 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Big_7 PF17957.1 ETO14550.1 - 0.1 13.4 0.2 20 6.0 0.0 3.3 4 0 0 4 4 3 0 Bacterial Ig domain ROS_MUCR PF05443.11 ETO14550.1 - 0.22 11.5 0.4 4 7.5 0.0 2.8 3 1 0 3 3 3 0 ROS/MUCR transcriptional regulator protein Roc PF08477.13 ETO14550.1 - 0.23 11.7 5.9 0.34 11.2 0.3 3.4 3 2 2 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase PUF PF00806.19 ETO14552.1 - 2.7e-22 77.1 1.9 4.8e-06 26.0 0.0 6.1 6 0 0 6 6 6 4 Pumilio-family RNA binding repeat Csm1_B PF18211.1 ETO14552.1 - 0.0052 16.6 0.1 0.012 15.4 0.1 1.6 1 0 0 1 1 1 1 Csm1 subunit domain B DUF2025 PF09634.10 ETO14552.1 - 0.057 13.4 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2025) Tcp11 PF05794.13 ETO14555.1 - 3.1e-12 46.3 0.4 3.1e-12 46.3 0.4 2.2 2 0 0 2 2 2 1 T-complex protein 11 S6PP_C PF08472.10 ETO14555.1 - 0.96 9.3 5.1 3.4 7.5 0.4 3.4 2 1 1 3 3 3 0 Sucrose-6-phosphate phosphohydrolase C-terminal FAD_binding_1 PF00667.20 ETO14557.1 - 5.2e-37 127.6 0.3 8.2e-37 126.9 0.0 1.5 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 ETO14557.1 - 6.1e-29 101.1 1.2 6.1e-29 101.1 1.2 2.2 3 0 0 3 3 3 1 Flavodoxin NAD_binding_1 PF00175.21 ETO14557.1 - 2.3e-13 50.7 0.0 9.1e-13 48.8 0.0 2.1 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETO14557.1 - 0.032 14.3 0.3 5.4 7.1 0.0 3.1 3 0 0 3 3 3 0 Ferric reductase NAD binding domain SpoIIIAH PF12685.7 ETO14558.1 - 0.00054 19.8 0.1 0.00058 19.8 0.1 1.0 1 0 0 1 1 1 1 SpoIIIAH-like protein TMEM208_SND2 PF05620.11 ETO14558.1 - 0.0016 18.2 0.6 0.0021 17.9 0.6 1.2 1 0 0 1 1 1 1 SRP-independent targeting protein 2/TMEM208 DUF4834 PF16118.5 ETO14558.1 - 0.0048 17.8 0.8 0.0053 17.7 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DUF4199 PF13858.6 ETO14558.1 - 0.0053 17.2 0.0 0.0057 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) Nucleoside_tran PF01733.18 ETO14558.1 - 0.014 14.8 0.1 0.015 14.7 0.1 1.0 1 0 0 1 1 1 0 Nucleoside transporter Connexin PF00029.19 ETO14558.1 - 0.039 13.7 0.9 0.046 13.5 0.9 1.1 1 0 0 1 1 1 0 Connexin DUF1682 PF07946.14 ETO14558.1 - 0.041 13.1 5.9 0.044 13.0 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DUF1774 PF08611.10 ETO14558.1 - 0.24 11.8 1.9 0.62 10.4 1.9 1.8 1 1 0 1 1 1 0 Fungal protein of unknown function (DUF1774) OATP PF03137.20 ETO14558.1 - 0.36 9.1 0.3 0.4 8.9 0.3 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Cytomega_UL84 PF06284.11 ETO14558.1 - 0.59 8.5 4.2 0.61 8.5 4.2 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3915 PF13054.6 ETO14558.1 - 1.1 9.3 6.0 1.4 8.9 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) AP3D1 PF06375.11 ETO14558.1 - 2.3 8.4 13.8 2.5 8.3 13.8 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Atrophin-1 PF03154.15 ETO14558.1 - 7.1 4.8 11.3 7.7 4.7 11.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family 7tm_3 PF00003.22 ETO14560.1 - 3.3e-37 128.5 23.4 3.3e-37 128.5 23.4 2.4 2 1 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Kelch_4 PF13418.6 ETO14560.1 - 9.9e-07 28.7 4.1 0.0016 18.4 0.3 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO14560.1 - 6.5e-06 26.2 9.3 3.3 8.1 0.0 6.7 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 ETO14560.1 - 2.2e-05 24.3 5.0 0.04 13.9 0.1 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO14560.1 - 0.00014 22.1 0.9 5.9 7.3 0.4 4.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14560.1 - 0.00075 19.4 0.1 0.96 9.5 0.0 4.5 3 0 0 3 3 3 1 Kelch motif DUF1129 PF06570.11 ETO14560.1 - 6.7 6.1 10.0 2.7 7.4 0.2 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1129) PDEase_I PF00233.19 ETO14561.1 - 2.2e-62 210.9 15.8 2.6e-61 207.4 15.8 2.4 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF_2 PF13185.6 ETO14561.1 - 2.5e-07 31.1 0.0 7.8e-07 29.5 0.0 1.9 1 0 0 1 1 1 1 GAF domain GAF PF01590.26 ETO14561.1 - 1.2e-06 29.1 0.1 5.8e-06 27.0 0.1 2.2 1 1 0 1 1 1 1 GAF domain GAF_3 PF13492.6 ETO14561.1 - 9e-05 22.8 0.2 0.00026 21.3 0.1 1.9 2 1 0 2 2 2 1 GAF domain SpoVT_C PF15714.5 ETO14561.1 - 0.00019 21.5 0.2 0.094 12.8 0.1 2.9 1 1 1 2 2 2 2 Stage V sporulation protein T C-terminal, transcription factor Secretin_N_2 PF07655.13 ETO14561.1 - 0.0092 16.5 23.6 0.051 14.1 13.2 2.5 2 0 0 2 2 2 2 Secretin N-terminal domain OATP PF03137.20 ETO14561.1 - 0.028 12.7 0.1 0.061 11.6 0.1 1.4 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family HD PF01966.22 ETO14561.1 - 0.12 12.6 0.1 0.45 10.7 0.1 2.1 1 0 0 1 1 1 0 HD domain POX PF07526.11 ETO14561.1 - 1.5 9.4 5.7 14 6.3 1.7 2.8 2 0 0 2 2 2 0 Associated with HOX Corazonin PF17308.2 ETO14561.1 - 4.6 7.6 26.8 1.8 8.9 12.4 2.8 2 0 0 2 2 2 0 Pro-corazonin Hist_deacetyl PF00850.19 ETO14563.1 - 2.3e-61 207.9 0.5 2.3e-61 207.9 0.5 1.6 2 0 0 2 2 2 1 Histone deacetylase domain YL1 PF05764.13 ETO14563.1 - 1 9.5 20.9 1.5 8.8 20.9 1.2 1 0 0 1 1 1 0 YL1 nuclear protein YtkA PF13115.6 ETO14564.1 - 0.12 13.0 0.0 0.18 12.4 0.0 1.3 1 0 0 1 1 1 0 YtkA-like Copine PF07002.16 ETO14565.1 - 6.4e-18 65.0 0.0 7.9e-18 64.7 0.0 1.1 1 0 0 1 1 1 1 Copine WW PF00397.26 ETO14565.1 - 7e-10 38.8 2.6 1.5e-09 37.7 2.6 1.6 1 0 0 1 1 1 1 WW domain C2 PF00168.30 ETO14566.1 - 6.9e-20 71.3 0.1 2.2e-09 37.5 0.0 3.3 3 0 0 3 3 3 3 C2 domain Copine PF07002.16 ETO14566.1 - 4.6e-18 65.5 0.1 4.3e-09 36.2 0.0 2.2 1 1 1 2 2 2 2 Copine DENN PF02141.21 ETO14567.1 - 1.2e-50 172.0 3.0 3.4e-50 170.6 3.0 1.8 1 0 0 1 1 1 1 DENN (AEX-3) domain dDENN PF03455.19 ETO14567.1 - 1.6e-12 47.2 3.0 7.3e-12 45.1 3.0 2.3 1 0 0 1 1 1 1 dDENN domain uDENN PF03456.18 ETO14567.1 - 2.3e-11 44.3 0.3 6.5e-11 42.8 0.3 1.8 1 0 0 1 1 1 1 uDENN domain FCH PF00611.23 ETO14567.1 - 1.6 9.1 12.0 0.72 10.2 1.7 4.3 4 0 0 4 4 4 0 Fes/CIP4, and EFC/F-BAR homology domain Med9 PF07544.13 ETO14567.1 - 8.6 6.5 10.1 11 6.2 4.3 3.4 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 WD40 PF00400.32 ETO14568.1 - 5.7e-107 346.6 44.8 2.2e-09 37.7 0.2 17.2 17 0 0 17 17 17 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14568.1 - 2.2e-25 88.8 14.1 0.38 11.1 0.0 13.7 1 1 14 15 15 15 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14568.1 - 1.3e-22 80.2 5.5 0.0056 15.7 0.0 10.9 3 3 6 10 10 10 5 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO14568.1 - 5.5e-08 32.9 0.0 1.4e-07 31.6 0.0 1.7 2 0 0 2 2 1 1 NACHT domain Pentapeptide PF00805.22 ETO14568.1 - 1.9e-07 30.6 2.3 4.1e-07 29.5 2.3 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Nbas_N PF15492.6 ETO14568.1 - 1.5e-05 24.5 10.5 3.7 6.8 0.0 8.8 3 3 7 11 11 11 1 Neuroblastoma-amplified sequence, N terminal AAA_18 PF13238.6 ETO14568.1 - 4.1e-05 24.1 0.0 0.0002 21.9 0.0 2.3 1 0 0 1 1 1 1 AAA domain PQQ_2 PF13360.6 ETO14568.1 - 4.7e-05 23.1 2.7 0.2 11.2 0.0 3.7 2 1 1 4 4 4 2 PQQ-like domain DUF5046 PF16465.5 ETO14568.1 - 5.9e-05 22.6 0.0 0.94 8.9 0.0 4.4 2 2 4 6 6 6 1 Domain of unknown function (DUF5046) AAA_22 PF13401.6 ETO14568.1 - 6e-05 23.3 0.0 0.00018 21.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain Pentapeptide_4 PF13599.6 ETO14568.1 - 0.00054 20.1 0.2 0.0015 18.6 0.2 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO14568.1 - 0.0039 17.3 0.8 0.01 16.0 0.8 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) RNA_helicase PF00910.22 ETO14568.1 - 0.0097 16.3 0.1 0.49 10.8 0.0 3.3 2 0 0 2 2 2 1 RNA helicase HARP PF07443.13 ETO14568.1 - 0.013 15.2 0.1 1.8 8.3 0.0 4.4 5 0 0 5 5 4 0 HepA-related protein (HARP) DUF5570 PF17731.1 ETO14568.1 - 0.015 15.4 17.4 4.7 7.3 0.1 7.6 4 4 5 9 9 7 0 Family of unknown function (DUF5570) DUF5319 PF17252.2 ETO14568.1 - 0.018 15.3 0.0 5.1 7.4 0.0 3.7 3 1 1 4 4 3 0 Family of unknown function (DUF5319) PD40 PF07676.12 ETO14568.1 - 0.024 14.6 21.8 66 3.6 0.0 9.9 11 0 0 11 11 10 0 WD40-like Beta Propeller Repeat TniB PF05621.11 ETO14568.1 - 0.067 12.6 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein TolB_N PF04052.13 ETO14568.1 - 0.069 13.3 0.1 1.7e+02 2.4 0.0 5.4 5 0 0 5 5 5 0 TolB amino-terminal domain S-l_SbsC_C PF18316.1 ETO14568.1 - 0.074 13.6 1.9 52 4.4 0.0 5.2 6 0 0 6 6 4 0 S-layer protein SbsC C-terminal domain eIF_4EBP PF05456.11 ETO14569.1 - 0.052 13.5 0.3 0.1 12.5 0.3 1.4 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) DUF554 PF04474.12 ETO14569.1 - 0.068 12.6 0.0 0.086 12.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF554) Bromodomain PF00439.25 ETO14570.1 - 1.6e-22 79.4 0.0 4.8e-22 77.8 0.0 1.9 1 0 0 1 1 1 1 Bromodomain Ribosomal_S17_N PF16205.5 ETO14570.1 - 0.049 14.0 4.5 0.37 11.2 4.5 2.5 1 0 0 1 1 1 0 Ribosomal_S17 N-terminal Presenilin PF01080.17 ETO14570.1 - 0.19 10.5 11.6 0.37 9.5 11.6 1.5 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO14570.1 - 0.33 10.1 4.1 0.53 9.5 4.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO14570.1 - 0.61 8.4 11.8 1.1 7.6 11.8 1.3 1 0 0 1 1 1 0 Menin DUF2490 PF10677.9 ETO14571.1 - 0.013 15.4 0.1 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2490) NT-C2 PF10358.9 ETO14571.1 - 0.018 14.8 8.3 0.15 11.8 8.3 2.2 1 1 0 1 1 1 0 N-terminal C2 in EEIG1 and EHBP1 proteins PBP5_C PF07943.13 ETO14572.1 - 0.064 13.5 0.3 0.11 12.8 0.3 1.4 1 0 0 1 1 1 0 Penicillin-binding protein 5, C-terminal domain Kelch_4 PF13418.6 ETO14573.1 - 0.00012 22.0 0.0 0.0014 18.6 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO14573.1 - 0.00022 21.1 1.6 1.5 8.9 0.4 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO14573.1 - 0.00025 21.2 2.9 22 5.5 0.0 4.5 3 1 1 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO14573.1 - 0.00034 20.1 2.6 0.11 12.0 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO14573.1 - 0.00035 20.4 5.8 0.06 13.4 0.2 4.2 6 0 0 6 6 6 2 Kelch motif SUIM_assoc PF16619.5 ETO14574.1 - 0.0015 18.6 8.5 0.0015 18.6 8.5 3.2 3 0 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 HALZ PF02183.18 ETO14577.1 - 0.0096 16.1 2.0 0.0096 16.1 2.0 4.3 3 2 1 4 4 4 1 Homeobox associated leucine zipper LMBR1 PF04791.16 ETO14577.1 - 0.013 14.5 14.1 0.015 14.2 14.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fic_N PF13784.6 ETO14577.1 - 0.022 14.8 1.9 0.022 14.8 1.9 1.7 2 0 0 2 2 1 0 Fic/DOC family N-terminal SHE3 PF17078.5 ETO14577.1 - 0.03 14.0 25.9 0.052 13.3 25.9 1.5 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 HSBP1 PF06825.12 ETO14577.1 - 0.054 13.4 6.9 1.1 9.2 1.9 3.1 2 1 0 2 2 2 0 Heat shock factor binding protein 1 Alanine_zipper PF11839.8 ETO14577.1 - 0.058 13.8 7.6 2 8.8 0.5 2.8 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein DUF3450 PF11932.8 ETO14577.1 - 0.11 11.8 28.9 0.43 9.8 9.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO14577.1 - 0.14 12.2 16.2 0.054 13.5 7.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) JIP_LZII PF16471.5 ETO14577.1 - 0.64 10.2 19.6 1.3 9.2 2.9 3.6 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II SNARE PF05739.19 ETO14577.1 - 0.91 9.6 5.6 0.68 10.0 1.0 2.7 2 0 0 2 2 2 0 SNARE domain FUSC PF04632.12 ETO14577.1 - 2.2 6.7 6.0 2.7 6.4 6.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FliD_N PF02465.18 ETO14577.1 - 2.8 8.7 17.2 12 6.7 5.1 2.6 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus GAGA_bind PF06217.12 ETO14577.1 - 3.1 8.0 15.8 4.2 7.6 15.8 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family DUF745 PF05335.13 ETO14577.1 - 3.5 7.3 20.2 4.6 6.9 5.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF948 PF06103.11 ETO14577.1 - 4.6 7.6 9.4 0.75 10.1 0.9 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Sec20 PF03908.13 ETO14577.1 - 5.3 7.0 11.7 14 5.7 5.4 3.0 1 1 1 2 2 2 0 Sec20 Occludin_ELL PF07303.13 ETO14577.1 - 5.5 7.8 22.9 1.5 9.6 14.3 2.7 1 1 1 2 2 2 0 Occludin homology domain TSC22 PF01166.18 ETO14577.1 - 5.6 7.4 12.8 0.16 12.3 1.9 3.1 2 1 1 3 3 3 0 TSC-22/dip/bun family NPV_P10 PF05531.12 ETO14577.1 - 7.3 7.1 12.4 6.6 7.3 0.9 2.5 1 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Dis3l2_C_term PF17877.1 ETO14578.1 - 0.14 12.5 0.4 0.36 11.2 0.3 1.7 1 1 0 1 1 1 0 DIS3-like exonuclease 2 C terminal OAD_gamma PF04277.13 ETO14579.1 - 0.54 10.9 0.1 0.54 10.9 0.1 2.8 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Peptidase_C14 PF00656.22 ETO14580.1 - 1.6e-05 25.0 2.1 7.4e-05 22.8 2.1 2.2 1 1 0 1 1 1 1 Caspase domain FAD_binding_1 PF00667.20 ETO14580.1 - 0.0035 16.9 0.1 0.0066 16.0 0.1 1.5 1 0 0 1 1 1 1 FAD binding domain TPR_12 PF13424.6 ETO14581.1 - 4e-96 315.4 26.6 3.4e-19 68.9 0.2 6.0 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14581.1 - 1.7e-59 196.2 0.2 1.1e-08 34.7 0.0 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14581.1 - 4.6e-43 143.3 48.8 1.2e-07 31.2 0.7 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14581.1 - 8.7e-37 122.3 47.1 6.6e-07 29.1 0.5 8.1 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14581.1 - 4.3e-36 120.3 9.4 8.7e-08 31.7 0.1 8.4 8 1 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14581.1 - 3e-32 108.1 35.6 3.1e-06 26.9 0.6 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14581.1 - 3.5e-19 67.7 19.9 0.015 15.7 1.5 8.2 5 2 1 7 7 7 7 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14581.1 - 6e-16 58.8 0.0 0.15 12.7 0.0 7.2 5 2 2 7 7 7 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO14581.1 - 2.6e-11 43.5 0.0 2.1e-05 24.1 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_6 PF13174.6 ETO14581.1 - 1.6e-09 37.8 9.9 0.83 10.4 0.1 7.7 8 0 0 8 8 8 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO14581.1 - 2.5e-09 37.1 22.2 0.64 9.8 0.0 6.9 5 2 2 7 7 7 5 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO14581.1 - 1.7e-08 34.6 0.0 0.15 13.0 0.0 6.8 6 1 2 8 8 8 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO14581.1 - 9.5e-08 32.0 20.8 0.044 13.5 4.6 4.7 1 1 3 5 5 5 3 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO14581.1 - 1.9e-05 24.7 26.7 0.92 9.6 0.8 7.5 8 0 0 8 8 8 2 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO14581.1 - 6.5e-05 22.8 26.3 0.03 14.3 1.5 6.6 6 0 0 6 6 6 1 Tetratricopeptide repeat DUF627 PF04781.12 ETO14581.1 - 7.6e-05 22.7 9.0 0.025 14.6 0.1 4.8 3 3 1 4 4 4 1 Protein of unknown function (DUF627) TPR_19 PF14559.6 ETO14581.1 - 0.00021 21.7 4.8 7.8 7.1 0.0 5.3 2 2 5 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14581.1 - 0.00091 19.4 24.1 0.0016 18.6 1.5 6.0 1 1 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF4810 PF16068.5 ETO14581.1 - 0.0043 17.6 12.1 7.8 7.1 0.2 5.5 4 2 1 5 5 5 0 Domain of unknown function (DUF4810) TPR_11 PF13414.6 ETO14581.1 - 0.0088 15.7 44.6 0.12 12.1 1.4 10.8 8 4 3 12 12 12 2 TPR repeat DUF2777 PF10949.8 ETO14581.1 - 0.014 15.1 4.2 17 5.0 0.0 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF2777) TPR_21 PF09976.9 ETO14581.1 - 0.027 14.2 0.5 0.027 14.2 0.5 3.2 4 1 0 4 4 4 0 Tetratricopeptide repeat-like domain MetOD2 PF18548.1 ETO14581.1 - 0.057 13.5 0.9 0.23 11.6 0.9 2.2 1 0 0 1 1 1 0 Metanogen output domain 2 PPR_2 PF13041.6 ETO14581.1 - 0.059 13.6 1.3 11 6.3 0.1 4.0 3 0 0 3 3 3 0 PPR repeat family PPR PF01535.20 ETO14581.1 - 0.36 11.2 16.2 1.7 9.1 0.2 6.8 8 0 0 8 8 8 0 PPR repeat ACDC PF14733.6 ETO14581.1 - 0.85 10.0 7.7 1.5 9.2 0.1 3.3 4 0 0 4 4 3 0 AP2-coincident C-terminal Mob_Pre PF01076.19 ETO14581.1 - 2.2 8.1 14.8 24 4.7 0.1 3.6 1 1 2 3 3 3 0 Plasmid recombination enzyme Fis1_TPR_C PF14853.6 ETO14581.1 - 3.6 7.7 23.6 7.5 6.7 0.1 6.3 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Ank_2 PF12796.7 ETO14582.1 - 9.4e-17 61.4 3.6 5e-07 30.2 0.1 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO14582.1 - 1.2e-15 56.1 5.8 0.0018 18.6 0.1 5.3 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ETO14582.1 - 4.5e-14 52.6 1.9 2.5e-05 24.7 0.1 3.7 2 2 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO14582.1 - 1.5e-10 41.1 1.4 0.027 14.9 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ETO14582.1 - 1.2e-08 35.0 10.7 0.025 14.9 0.0 4.8 3 1 1 4 4 4 4 Ankyrin repeats (many copies) E3_UbLigase_RBR PF18091.1 ETO14582.1 - 0.0015 18.7 1.1 0.0015 18.7 1.1 1.8 2 0 0 2 2 2 1 E3 Ubiquitin Ligase RBR C-terminal domain SAP18 PF06487.12 ETO14582.1 - 0.079 13.1 2.8 0.22 11.7 0.5 2.1 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) Presenilin PF01080.17 ETO14582.1 - 1.1 7.9 2.7 1.4 7.6 2.7 1.2 1 0 0 1 1 1 0 Presenilin DUF3825 PF12873.7 ETO14584.1 - 1.6e-19 70.3 0.4 2.9e-19 69.5 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3825) Dynamin_N PF00350.23 ETO14584.1 - 2.3 8.3 10.0 0.3 11.1 5.4 2.0 2 1 0 2 2 2 0 Dynamin family DUF4638 PF15472.6 ETO14584.1 - 2.4 7.9 11.9 20 4.8 8.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4638) NTP_transferase PF00483.23 ETO14585.1 - 5e-11 42.7 0.0 9.8e-11 41.7 0.0 1.5 1 1 0 1 1 1 1 Nucleotidyl transferase GHMP_kinases_N PF00288.26 ETO14585.1 - 9.3e-10 38.6 0.0 2.1e-09 37.5 0.0 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.9 ETO14585.1 - 0.039 13.5 0.1 0.15 11.6 0.0 2.1 2 0 0 2 2 2 0 Galactokinase galactose-binding signature RgpF PF05045.12 ETO14585.1 - 0.11 11.2 0.0 0.19 10.4 0.0 1.3 1 0 0 1 1 1 0 Rhamnan synthesis protein F Mic1 PF07035.12 ETO14586.1 - 1.9e-15 56.9 1.3 2.5e-07 30.5 0.0 2.7 2 0 0 2 2 2 2 Colon cancer-associated protein Mic1-like DUF4746 PF15928.5 ETO14586.1 - 0.025 14.0 7.0 0.049 13.1 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.17 ETO14586.1 - 0.049 13.8 0.2 0.097 12.8 0.2 1.7 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 ETO14586.1 - 0.082 11.9 3.3 0.045 12.7 1.1 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) TLP-20 PF06088.11 ETO14586.1 - 0.09 12.7 5.6 0.2 11.6 5.6 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) RNA_pol_Rpc4 PF05132.14 ETO14586.1 - 0.13 12.7 1.8 0.27 11.7 1.8 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 RXT2_N PF08595.11 ETO14586.1 - 0.14 12.2 9.9 0.41 10.7 9.9 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal CDC45 PF02724.14 ETO14586.1 - 0.15 10.3 11.5 0.22 9.8 11.5 1.2 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 ETO14586.1 - 0.15 12.0 11.6 0.2 11.6 10.0 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Pox_Ag35 PF03286.14 ETO14586.1 - 0.26 11.0 14.0 0.55 10.0 14.0 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2052 PF09747.9 ETO14586.1 - 0.35 11.0 15.7 0.056 13.6 10.6 2.0 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Presenilin PF01080.17 ETO14586.1 - 0.43 9.3 5.7 0.76 8.5 5.7 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO14586.1 - 0.58 9.3 2.2 0.92 8.7 2.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TRAP_alpha PF03896.16 ETO14586.1 - 0.61 9.2 7.2 1.1 8.4 7.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Connexin PF00029.19 ETO14586.1 - 0.66 9.7 5.9 3.4 7.3 5.9 2.0 2 0 0 2 2 2 0 Connexin Vfa1 PF08432.10 ETO14586.1 - 0.81 10.0 12.0 1.9 8.8 12.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DNA_pol_phi PF04931.13 ETO14586.1 - 0.93 7.5 15.4 1.7 6.7 15.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ETO14586.1 - 1.5 8.5 10.6 3.4 7.3 10.6 1.6 1 0 0 1 1 1 0 FAM176 family ALMT PF11744.8 ETO14586.1 - 1.8 7.3 7.6 0.41 9.4 3.6 1.8 2 0 0 2 2 2 0 Aluminium activated malate transporter PTPRCAP PF15713.5 ETO14586.1 - 2.2 8.5 17.7 2.4 8.4 16.2 1.8 2 0 0 2 2 1 0 Protein tyrosine phosphatase receptor type C-associated CobT PF06213.12 ETO14586.1 - 3.8 6.8 14.0 6.6 6.0 14.0 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PBP1_TM PF14812.6 ETO14586.1 - 4 7.9 12.6 9.5 6.7 12.6 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BSP_II PF05432.11 ETO14586.1 - 4.3 6.9 22.8 11 5.7 22.8 1.6 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CPSF100_C PF13299.6 ETO14586.1 - 5.1 7.3 9.2 11 6.1 9.2 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ANAPC_CDC26 PF10471.9 ETO14587.1 - 0.52 11.2 4.9 1 10.2 4.9 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex APC subunit CDC26 DUF948 PF06103.11 ETO14588.1 - 0.011 15.9 4.8 0.011 15.9 4.8 6.9 5 2 1 6 6 6 0 Bacterial protein of unknown function (DUF948) AhpC-TSA PF00578.21 ETO14588.1 - 0.11 12.4 1.6 2 8.3 0.1 3.2 2 0 0 2 2 2 0 AhpC/TSA family Tetraspanin PF00335.20 ETO14589.1 - 8.8e-14 51.8 14.2 1.7e-13 50.9 14.2 1.5 1 0 0 1 1 1 1 Tetraspanin family MAP17 PF15807.5 ETO14589.1 - 0.022 15.0 0.0 0.069 13.4 0.0 1.8 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SUR7 PF06687.12 ETO14589.1 - 0.1 12.2 5.5 0.18 11.4 5.4 1.7 1 1 0 1 1 1 0 SUR7/PalI family YfhO PF09586.10 ETO14589.1 - 0.12 10.6 1.7 0.16 10.2 1.7 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4728 PF15860.5 ETO14589.1 - 0.83 10.4 9.1 0.22 12.2 2.3 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4728) WD40 PF00400.32 ETO14590.1 - 5.5e-129 416.3 50.3 2e-09 37.9 0.2 16.3 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14590.1 - 1.5e-35 121.4 13.9 0.008 16.4 0.0 12.9 1 1 10 12 12 12 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14590.1 - 2.8e-19 69.2 4.6 0.12 11.4 0.0 12.3 3 2 12 15 15 15 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14590.1 - 1.1e-17 64.4 18.5 0.012 14.9 0.1 8.4 2 2 5 8 8 8 7 WD40-like domain Nup160 PF11715.8 ETO14590.1 - 2.1e-16 59.7 20.5 0.17 10.5 0.1 13.1 5 3 7 13 13 13 5 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO14590.1 - 4.3e-09 35.8 2.9 7.8e-09 35.0 2.9 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO14590.1 - 6.8e-06 26.1 1.0 20 5.4 0.0 7.1 6 3 1 7 7 7 0 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO14590.1 - 9.7e-05 22.5 0.1 0.00025 21.1 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO14590.1 - 0.0002 21.4 2.7 6.8 6.9 0.0 5.7 6 0 0 6 6 6 1 Domain of unknown function (DUF3475) Cytochrom_D1 PF02239.16 ETO14590.1 - 0.00026 19.6 11.7 1.6 7.2 0.1 6.1 5 1 1 6 6 6 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO14590.1 - 0.0005 18.9 0.7 7.7 5.2 0.0 5.9 6 1 1 8 8 8 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pentapeptide_3 PF13576.6 ETO14590.1 - 0.00052 20.1 0.3 0.0013 18.8 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) VID27 PF08553.10 ETO14590.1 - 0.00077 18.6 0.9 0.17 10.9 0.0 3.8 4 0 0 4 4 4 1 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO14590.1 - 0.064 13.2 20.0 30 4.7 0.0 9.4 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat Surfac_D-trimer PF09006.11 ETO14590.1 - 0.068 13.1 1.2 4.5 7.2 0.1 4.3 5 0 0 5 5 5 0 Lung surfactant protein D coiled-coil trimerisation UPF0147 PF03685.13 ETO14590.1 - 0.083 12.9 1.3 0.28 11.3 1.3 1.9 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) Peptidase_S10 PF00450.22 ETO14591.1 - 1.4e-52 179.5 0.4 3.2e-52 178.3 0.4 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase CREPT PF16566.5 ETO14592.1 - 0.25 11.5 1.5 0.4 10.9 1.5 1.3 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour WD40 PF00400.32 ETO14593.1 - 4.3e-39 131.8 31.3 7e-07 29.8 1.9 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO14593.1 - 7e-14 51.4 8.1 0.0021 16.8 0.1 5.0 2 2 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14593.1 - 3.4e-10 40.1 2.6 0.27 11.6 0.0 5.7 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Rsd_AlgQ PF04353.13 ETO14594.1 - 0.016 15.2 9.8 0.16 11.9 0.8 3.8 5 0 0 5 5 5 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ CDH1_2_SANT_HL1 PF18375.1 ETO14594.1 - 0.047 14.4 0.2 0.44 11.3 0.2 2.7 1 0 0 1 1 1 0 CDH1/2 SANT-Helical linker 1 Salp15 PF12115.8 ETO14594.1 - 0.12 12.8 0.8 0.49 10.8 0.2 2.4 2 0 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation DUF4570 PF15134.6 ETO14594.1 - 1 9.4 6.1 0.27 11.2 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) AAA_24 PF13479.6 ETO14594.1 - 3.5 7.3 7.1 0.48 10.1 0.7 2.6 2 1 1 3 3 3 0 AAA domain TMEM70 PF06979.12 ETO14595.1 - 0.11 13.0 0.1 0.95 9.9 0.0 2.2 2 0 0 2 2 2 0 Assembly, mitochondrial proton-transport ATP synth complex SBDS PF01172.18 ETO14596.1 - 2.9e-16 59.3 0.4 3.5e-16 59.0 0.4 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Putative_PNPOx PF01243.20 ETO14596.1 - 0.12 12.6 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase cobW PF02492.19 ETO14597.1 - 0.00049 19.7 0.0 0.00072 19.2 0.0 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain Fn3-like PF14310.6 ETO14599.1 - 5.6e-07 29.6 0.2 1.1e-06 28.6 0.2 1.5 1 0 0 1 1 1 1 Fibronectin type III-like domain Ank_2 PF12796.7 ETO14600.1 - 1.3e-05 25.7 0.2 8.4e-05 23.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO14600.1 - 2.2e-05 24.5 0.0 0.022 15.2 0.0 3.3 2 0 0 2 2 2 1 Ankyrin repeat Ank PF00023.30 ETO14600.1 - 0.00036 20.8 0.0 0.024 15.1 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO14600.1 - 0.006 17.1 0.1 0.065 13.8 0.1 2.7 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO14600.1 - 0.007 16.7 6.2 0.19 12.1 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Secretin_N_2 PF07655.13 ETO14600.1 - 0.4 11.3 20.3 0.25 11.9 5.3 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain WD40 PF00400.32 ETO14601.1 - 1.8e-09 38.1 4.7 6.9e-07 29.9 1.0 2.8 2 0 0 2 2 2 2 WD domain, G-beta repeat Tim54 PF11711.8 ETO14602.1 - 0.0057 15.5 2.6 0.0065 15.3 2.6 1.0 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 CSG2 PF16965.5 ETO14602.1 - 0.017 14.1 0.5 0.019 13.9 0.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Herpes_UL49_1 PF03117.14 ETO14602.1 - 0.03 13.6 0.1 0.041 13.2 0.1 1.1 1 0 0 1 1 1 0 UL49 family F-protein PF00469.20 ETO14602.1 - 0.057 13.0 1.9 0.057 13.0 1.9 1.1 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef Presenilin PF01080.17 ETO14602.1 - 0.063 12.0 2.7 0.067 11.9 2.7 1.1 1 0 0 1 1 1 0 Presenilin Peroxin-13_N PF04088.13 ETO14602.1 - 0.077 13.3 0.1 0.11 12.8 0.1 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region NPR3 PF03666.13 ETO14602.1 - 0.094 11.5 9.6 0.12 11.2 9.6 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SID-1_RNA_chan PF13965.6 ETO14602.1 - 0.1 11.0 1.3 0.11 10.8 1.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Pox_Ag35 PF03286.14 ETO14602.1 - 0.13 12.1 12.8 0.15 11.8 12.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Connexin PF00029.19 ETO14602.1 - 0.2 11.4 3.1 0.24 11.1 3.1 1.1 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ETO14602.1 - 0.29 10.3 1.5 0.32 10.2 1.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sec62 PF03839.16 ETO14602.1 - 0.31 10.5 2.8 0.35 10.4 2.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RNA_pol_Rpc4 PF05132.14 ETO14602.1 - 0.35 11.3 4.6 0.4 11.1 4.6 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETO14602.1 - 0.45 8.8 8.6 0.51 8.6 8.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3464 PF11947.8 ETO14602.1 - 0.6 9.9 2.2 0.77 9.5 2.2 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CPSF100_C PF13299.6 ETO14602.1 - 0.65 10.2 6.1 0.81 9.8 6.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal E7 PF00527.18 ETO14602.1 - 1.2 9.4 10.1 0.75 10.0 0.2 2.2 1 1 1 2 2 2 0 E7 protein, Early protein DUF3043 PF11241.8 ETO14602.1 - 1.5 8.8 7.0 2.1 8.4 7.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) PPL5 PF18168.1 ETO14602.1 - 2.1 7.6 7.3 2.4 7.4 7.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 TFIIF_alpha PF05793.12 ETO14602.1 - 5.4 5.5 19.1 6.5 5.2 19.1 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF2457 PF10446.9 ETO14602.1 - 7.9 5.5 18.6 9.3 5.3 18.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TRAPPC9-Trs120 PF08626.11 ETO14604.1 - 0.011 13.1 0.0 0.013 12.9 0.0 1.0 1 0 0 1 1 1 0 Transport protein Trs120 or TRAPPC9, TRAPP II complex subunit ELO PF01151.18 ETO14607.1 - 2.3e-54 184.6 30.1 2.5e-54 184.4 30.1 1.0 1 0 0 1 1 1 1 GNS1/SUR4 family Equine_IAV_S2 PF06502.11 ETO14607.1 - 0.05 13.7 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Equine infectious anaemia virus S2 protein PCMT PF01135.19 ETO14608.1 - 1.4e-20 74.0 0.0 3.5e-20 72.7 0.0 1.6 1 1 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_31 PF13847.6 ETO14608.1 - 4.9e-08 32.9 0.0 9.2e-08 32.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO14608.1 - 9.6e-05 23.0 0.0 0.00022 21.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO14608.1 - 0.00028 20.9 0.1 0.00078 19.5 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO14608.1 - 0.0045 16.8 0.0 0.0087 15.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO14608.1 - 0.0089 16.7 0.0 0.018 15.7 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ETO14608.1 - 0.017 14.8 0.0 0.035 13.8 0.0 1.5 1 0 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_12 PF08242.12 ETO14608.1 - 0.046 14.5 0.0 0.1 13.3 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain FlaC_arch PF05377.11 ETO14608.1 - 0.084 13.3 2.3 0.19 12.1 2.3 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) zf-TRAF PF02176.18 ETO14609.1 - 5.3e-05 23.8 4.3 5.3e-05 23.8 4.3 2.7 3 0 0 3 3 3 1 TRAF-type zinc finger RAP1 PF07218.11 ETO14609.1 - 0.0099 14.2 2.0 0.012 13.9 2.0 1.1 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) Sina PF03145.16 ETO14609.1 - 1.5 8.7 13.9 0.032 14.2 5.3 2.1 2 0 0 2 2 2 0 Seven in absentia protein family Strabismus PF06638.11 ETO14610.1 - 0.24 10.0 4.6 0.27 9.8 4.6 1.0 1 0 0 1 1 1 0 Strabismus protein DUF2981 PF11200.8 ETO14610.1 - 1.5 8.5 8.6 1.7 8.3 8.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) RR_TM4-6 PF06459.12 ETO14610.1 - 2.4 7.9 19.1 3.1 7.6 19.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.6 ETO14610.1 - 3.6 7.1 10.4 4.5 6.8 10.4 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain CCSAP PF15748.5 ETO14610.1 - 4.5 7.4 18.2 5.4 7.1 18.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Neur_chan_memb PF02932.16 ETO14610.1 - 5 7.1 9.8 5.5 7.0 9.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PDDEXK_6 PF04720.12 ETO14610.1 - 6.3 6.7 11.9 8.6 6.2 11.9 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function YABBY PF04690.13 ETO14610.1 - 6.6 7.3 8.2 8.2 7.0 8.2 1.2 1 0 0 1 1 1 0 YABBY protein Peptidase_S64 PF08192.11 ETO14610.1 - 6.6 5.1 12.7 7.6 4.9 12.7 1.0 1 0 0 1 1 1 0 Peptidase family S64 SLC12 PF03522.15 ETO14610.1 - 7.2 5.5 18.2 8.1 5.4 18.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 CAML PF14963.6 ETO14610.1 - 7.3 6.6 10.2 9.5 6.2 10.2 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand Atg14 PF10186.9 ETO14610.1 - 7.7 5.5 15.3 8.8 5.3 15.3 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 CDC45 PF02724.14 ETO14610.1 - 7.9 4.6 22.8 8.5 4.5 22.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO14611.1 - 0.15 11.2 13.4 0.18 11.0 13.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIA PF03153.13 ETO14611.1 - 0.95 9.4 41.2 1.2 9.1 41.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Lin-8 PF03353.15 ETO14611.1 - 2.5 7.6 31.0 3.2 7.2 31.0 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Ndc1_Nup PF09531.10 ETO14611.1 - 2.6 6.6 18.5 3.1 6.4 18.5 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ETO14611.1 - 3.7 6.2 24.0 5 5.8 24.0 1.3 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 ETO14611.1 - 6.6 4.9 34.7 7.9 4.6 34.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DpnII PF04556.12 ETO14612.1 - 0.02 14.2 0.4 0.023 14.0 0.4 1.1 1 0 0 1 1 1 0 DpnII restriction endonuclease fn3_4 PF16794.5 ETO14612.1 - 0.021 14.8 0.1 0.028 14.4 0.1 1.3 1 0 0 1 1 1 0 Fibronectin-III type domain CAGE1 PF15066.6 ETO14612.1 - 0.042 12.5 1.6 0.047 12.4 1.6 1.1 1 0 0 1 1 1 0 Cancer-associated gene protein 1 family KinB_sensor PF16767.5 ETO14613.1 - 0.079 13.4 3.7 0.21 12.1 0.9 2.9 1 1 1 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB DUF1722 PF08349.11 ETO14613.1 - 5.5 7.3 10.7 1 9.6 1.7 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF1722) Aconitase PF00330.20 ETO14614.1 - 1.9e-148 495.3 0.0 2.3e-148 495.0 0.0 1.1 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) Aconitase_C PF00694.19 ETO14614.1 - 3.5e-41 140.6 0.0 8.5e-41 139.3 0.0 1.6 2 0 0 2 2 2 1 Aconitase C-terminal domain DUF521 PF04412.13 ETO14614.1 - 0.0036 16.1 0.1 0.013 14.2 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF521) Peptidase_M78 PF06114.13 ETO14614.1 - 0.14 12.1 0.0 0.27 11.2 0.0 1.4 1 0 0 1 1 1 0 IrrE N-terminal-like domain Kelch_6 PF13964.6 ETO14615.1 - 2.6e-13 49.7 3.5 2.3e-07 30.8 0.2 4.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO14615.1 - 1.9e-07 30.6 2.0 0.00072 19.1 0.2 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO14615.1 - 1.3e-06 28.2 5.8 0.00071 19.5 1.8 4.5 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO14615.1 - 3.8e-06 26.8 0.4 0.00012 22.0 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO14615.1 - 7.3e-05 23.0 0.3 0.0014 18.9 0.0 3.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14615.1 - 0.012 15.5 4.8 0.47 10.5 0.2 4.1 5 1 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO14617.1 - 7.6e-18 64.5 9.0 3.3e-07 30.9 0.3 3.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14617.1 - 0.0023 18.2 0.1 1.6 9.1 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO14617.1 - 0.0026 17.2 0.1 0.0052 16.1 0.1 1.5 1 0 0 1 1 1 1 WD40-like domain NHL PF01436.21 ETO14617.1 - 0.053 13.6 2.2 0.46 10.6 0.1 3.1 3 0 0 3 3 3 0 NHL repeat HSP70 PF00012.20 ETO14618.1 - 8.6e-123 410.6 0.1 7.3e-72 242.4 0.0 2.0 2 0 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO14618.1 - 0.0021 17.0 0.1 0.0056 15.5 0.0 1.6 2 0 0 2 2 2 1 MreB/Mbl protein Peptidase_M16 PF00675.20 ETO14618.1 - 0.11 12.4 0.1 0.35 10.8 0.1 1.8 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) SAPS PF04499.15 ETO14620.1 - 2.4 6.8 9.2 2.9 6.6 9.2 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4407 PF14362.6 ETO14620.1 - 3.1 7.0 7.7 3.9 6.7 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SLC12 PF03522.15 ETO14620.1 - 3.6 6.5 9.0 4.3 6.3 9.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Trypan_PARP PF05887.11 ETO14620.1 - 4.2 7.3 9.8 5.3 7.0 9.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Neur_chan_memb PF02932.16 ETO14620.1 - 4.3 7.3 7.9 6.2 6.8 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region p450 PF00067.22 ETO14621.1 - 7.7e-12 44.7 2.8 8.4e-12 44.6 2.8 1.1 1 0 0 1 1 1 1 Cytochrome P450 GCP_N_terminal PF17681.1 ETO14622.1 - 4.2e-10 39.8 1.4 6.7e-10 39.1 1.4 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Fes1 PF08609.10 ETO14622.1 - 0.029 15.2 1.1 5.4 8.0 0.1 2.5 2 0 0 2 2 2 0 Nucleotide exchange factor Fes1 YMF19 PF02326.15 ETO14622.1 - 0.71 10.7 13.1 0.11 13.3 7.5 2.6 3 0 0 3 3 3 0 Plant ATP synthase F0 DUF4834 PF16118.5 ETO14622.1 - 2 9.4 9.0 0.32 12.0 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO14623.1 - 4e-27 93.9 21.8 5.8e-07 30.1 0.1 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO14623.1 - 7.5e-09 34.8 1.9 0.021 13.5 0.0 4.3 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14623.1 - 1.1e-08 35.2 0.8 0.31 11.4 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO14623.1 - 0.00024 20.5 12.6 0.0016 17.8 2.4 3.5 3 1 1 4 4 4 2 WD40-like domain PHR PF08005.12 ETO14624.1 - 3.8e-29 102.3 0.8 3.8e-29 102.3 0.8 1.8 2 0 0 2 2 2 1 PHR domain BTB PF00651.31 ETO14624.1 - 6e-14 52.2 0.1 1.3e-13 51.2 0.1 1.5 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ETO14624.1 - 0.18 11.9 1.4 0.41 10.8 0.2 2.1 2 0 0 2 2 2 0 BTB And C-terminal Kelch zf-CCCH PF00642.24 ETO14625.1 - 3e-09 36.6 1.2 6e-09 35.6 1.2 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO14625.1 - 6.3e-05 22.9 1.7 0.00013 21.9 1.7 1.5 1 0 0 1 1 1 1 Zinc finger domain Menin PF05053.13 ETO14625.1 - 0.47 8.7 5.8 0.84 7.9 5.8 1.3 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO14625.1 - 8.7 7.0 21.7 0.93 10.1 16.4 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain COX6B PF02297.17 ETO14626.1 - 5.2 7.4 9.0 1.2 9.4 4.4 2.1 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIb Phage_cap_P2 PF05125.12 ETO14627.1 - 0.043 12.8 0.0 0.059 12.3 0.0 1.2 1 0 0 1 1 1 0 Phage major capsid protein, P2 family COMM_domain PF07258.14 ETO14628.1 - 7.7e-14 51.6 0.4 1.7e-13 50.5 0.4 1.6 1 0 0 1 1 1 1 COMM domain SusE PF14292.6 ETO14628.1 - 0.049 13.9 1.0 1.6 9.0 0.1 2.3 2 0 0 2 2 2 0 SusE outer membrane protein DUF2140 PF09911.9 ETO14628.1 - 0.072 12.6 0.6 1.1 8.8 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) DUF3826 PF12875.7 ETO14628.1 - 0.088 13.0 1.4 0.12 12.5 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3826) SLX9 PF15341.6 ETO14628.1 - 0.5 10.8 4.9 7.4 7.0 5.4 2.6 1 1 1 2 2 2 0 Ribosome biogenesis protein SLX9 Mss4 PF04421.13 ETO14629.1 - 0.05 13.7 0.3 0.05 13.7 0.3 2.9 3 0 0 3 3 3 0 Mss4 protein WD40 PF00400.32 ETO14630.1 - 0.0003 21.5 1.9 5.9 7.9 0.1 4.5 4 1 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14630.1 - 0.0025 18.1 0.0 3.4 8.0 0.0 3.3 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO14630.1 - 0.0033 17.3 0.7 0.072 13.0 0.0 2.4 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO14630.1 - 0.0041 17.0 0.3 29 4.7 0.0 3.9 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO14630.1 - 0.031 13.6 0.1 2.1 7.6 0.0 2.9 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal GLE1 PF07817.13 ETO14631.1 - 2.2e-10 40.2 0.1 2.9e-10 39.8 0.1 1.1 1 0 0 1 1 1 1 GLE1-like protein DUF2258 PF10015.9 ETO14632.1 - 0.087 13.0 0.2 0.29 11.3 0.2 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) SET PF00856.28 ETO14634.1 - 0.00017 22.0 0.2 0.00039 20.8 0.1 1.7 2 0 0 2 2 2 1 SET domain Menin PF05053.13 ETO14635.1 - 4.6 5.5 12.6 7 4.9 12.6 1.5 1 0 0 1 1 1 0 Menin DUF4446 PF14584.6 ETO14637.1 - 0.065 13.2 1.3 0.11 12.5 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) DUF5527 PF17665.1 ETO14637.1 - 0.1 12.1 0.0 0.18 11.3 0.0 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5527) DUF3139 PF11337.8 ETO14637.1 - 0.66 10.7 6.8 0.26 12.0 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) DUF2890 PF11081.8 ETO14638.1 - 0.011 15.9 1.8 0.016 15.3 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2890) Hamartin PF04388.12 ETO14638.1 - 0.25 10.0 6.5 0.29 9.7 6.5 1.1 1 0 0 1 1 1 0 Hamartin protein Velvet PF11754.8 ETO14638.1 - 0.53 10.2 9.8 3.7 7.4 0.0 2.9 2 1 0 2 2 2 0 Velvet factor DUF2615 PF11027.8 ETO14638.1 - 3.7 7.7 0.0 3.7 7.7 0.0 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2615) PRCC PF10253.9 ETO14638.1 - 4.6 8.0 14.3 6.4 7.5 13.6 1.6 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting Destabilase PF05497.12 ETO14638.1 - 6.2 7.2 11.9 0.27 11.6 4.2 2.4 2 1 0 2 2 2 0 Destabilase EF-hand_1 PF00036.32 ETO14639.1 - 8e-16 56.3 12.1 2.4e-05 23.5 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ETO14639.1 - 6.1e-11 41.3 16.9 0.00046 19.9 0.8 4.0 3 2 2 5 5 5 3 EF-hand domain EF-hand_7 PF13499.6 ETO14639.1 - 1.8e-10 41.1 11.0 0.0051 17.2 0.1 3.4 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO14639.1 - 3.1e-10 39.1 14.5 0.00088 18.7 0.9 3.7 2 1 1 3 3 3 3 EF hand EF-hand_8 PF13833.6 ETO14639.1 - 5.7e-10 38.9 6.9 0.0046 16.8 0.3 3.5 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO14639.1 - 8.4e-06 25.7 11.5 1.5e-05 24.9 1.2 3.0 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand Phosducin PF02114.16 ETO14639.1 - 0.037 13.0 2.0 0.05 12.5 2.0 1.2 1 0 0 1 1 1 0 Phosducin Abhydro_lipase PF04083.16 ETO14640.1 - 2.1e-21 75.2 0.0 3.9e-21 74.4 0.0 1.5 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ETO14640.1 - 1.2e-13 51.4 0.1 4.5e-13 49.4 0.1 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO14640.1 - 0.012 14.9 0.0 0.33 10.2 0.0 2.3 2 0 0 2 2 2 0 Serine aminopeptidase, S33 Homeobox_KN PF05920.11 ETO14641.1 - 1.2e-14 53.9 0.3 2e-14 53.2 0.3 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ETO14641.1 - 3.8e-09 36.2 0.8 6.9e-09 35.4 0.8 1.4 1 0 0 1 1 1 1 Homeodomain Osmo_MPGsynth PF09488.10 ETO14642.1 - 0.051 12.3 0.0 0.076 11.7 0.0 1.3 1 0 0 1 1 1 0 Mannosyl-3-phosphoglycerate synthase (osmo_MPGsynth) Menin PF05053.13 ETO14642.1 - 0.53 8.6 4.6 0.52 8.6 4.6 1.1 1 0 0 1 1 1 0 Menin MARCKS PF02063.17 ETO14642.1 - 1.4 8.9 4.3 0.44 10.5 1.9 1.4 2 0 0 2 2 2 0 MARCKS family F-box PF00646.33 ETO14643.1 - 0.0077 16.1 0.4 0.02 14.8 0.0 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ETO14643.1 - 0.01 15.7 0.1 0.031 14.2 0.0 1.9 2 0 0 2 2 2 0 F-box-like DUF3311 PF11755.8 ETO14644.1 - 0.0071 16.3 0.1 0.01 15.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3311) RSB_motif PF16294.5 ETO14646.1 - 0.037 14.3 2.0 0.15 12.3 2.0 2.0 1 0 0 1 1 1 0 RNSP1-SAP18 binding (RSB) motif Trypan_PARP PF05887.11 ETO14646.1 - 0.048 13.7 7.1 0.093 12.7 7.1 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Neisseria_TspB PF05616.13 ETO14646.1 - 0.85 8.0 14.5 1.6 7.1 14.5 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein TatC PF00902.18 ETO14647.1 - 0.17 11.7 2.2 0.28 11.0 2.2 1.3 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) DUF2207 PF09972.9 ETO14647.1 - 0.22 10.2 5.2 2.4 6.8 5.2 2.0 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) T6PP_N PF18572.1 ETO14648.1 - 0.13 12.1 2.6 0.23 11.3 2.6 1.5 1 1 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF4242 PF14026.6 ETO14649.1 - 0.048 13.8 0.1 0.095 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4242) DUF5352 PF17303.2 ETO14649.1 - 0.05 13.4 0.3 0.091 12.6 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5352) Apolipoprotein PF01442.18 ETO14650.1 - 0.07 13.0 13.5 0.035 14.0 10.9 1.8 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain DUF1541 PF07563.11 ETO14650.1 - 0.092 12.6 3.5 0.27 11.1 3.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1541) PRP1_N PF06424.12 ETO14650.1 - 1.2 9.5 15.4 2.5 8.5 2.5 2.7 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Kelch_4 PF13418.6 ETO14651.1 - 0.0053 16.7 0.2 0.72 9.9 0.1 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Methyltransf_FA PF12248.8 ETO14651.1 - 0.013 15.8 3.8 0.063 13.6 1.1 2.6 2 0 0 2 2 2 0 Farnesoic acid 0-methyl transferase Kelch_1 PF01344.25 ETO14651.1 - 0.022 14.3 1.0 1.3 8.6 0.1 3.7 4 1 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO14651.1 - 0.081 12.9 2.0 2.3 8.3 0.2 3.8 5 0 0 5 5 5 0 Kelch motif DUF2951 PF11166.8 ETO14653.1 - 0.025 14.8 1.7 0.035 14.3 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF617 PF04759.13 ETO14653.1 - 0.12 12.4 0.0 0.14 12.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function, DUF617 RLL PF10036.9 ETO14654.1 - 2.3e-70 237.4 3.5 2.8e-70 237.1 3.5 1.1 1 0 0 1 1 1 1 RNA transcription, translation and transport factor protein UvrD-helicase PF00580.21 ETO14654.1 - 0.037 13.5 4.1 0.048 13.2 4.1 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Methyltransf_25 PF13649.6 ETO14655.1 - 0.0041 17.8 0.0 0.018 15.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO14655.1 - 0.025 14.4 0.0 0.078 12.8 0.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_23 PF13489.6 ETO14655.1 - 0.054 13.3 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ETO14655.1 - 0.15 12.8 2.5 0.66 10.8 0.0 2.8 3 1 0 3 3 3 0 Methyltransferase domain Ferlin_C PF16165.5 ETO14655.1 - 6.6 6.7 6.6 0.67 9.9 0.4 2.4 3 1 0 3 3 3 0 Ferlin C-terminus XRCC4 PF06632.12 ETO14656.1 - 0.0095 14.8 6.4 0.013 14.4 6.4 1.1 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 zf-RING_5 PF14634.6 ETO14656.1 - 0.18 11.8 11.8 0.057 13.4 8.3 1.9 1 1 1 2 2 2 0 zinc-RING finger domain DUF4834 PF16118.5 ETO14656.1 - 0.22 12.5 1.8 0.37 11.8 1.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) zf-RING_UBOX PF13445.6 ETO14656.1 - 0.39 10.8 9.7 0.059 13.4 5.1 2.0 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETO14656.1 - 6 7.1 12.0 0.31 11.2 3.5 2.6 1 1 2 3 3 3 0 zinc finger of C3HC4-type, RING Ribosomal_S16 PF00886.19 ETO14657.1 - 2e-05 24.5 0.0 4.2e-05 23.5 0.0 1.6 1 0 0 1 1 1 1 Ribosomal protein S16 Voltage_CLC PF00654.20 ETO14658.1 - 1.7 7.8 6.0 0.63 9.2 2.8 1.9 1 1 0 1 1 1 0 Voltage gated chloride channel Myotub-related PF06602.14 ETO14659.1 - 4.1e-111 371.3 2.7 6.4e-111 370.7 2.7 1.3 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain C2 PF00168.30 ETO14659.1 - 1.7e-14 54.0 0.0 5.1e-14 52.4 0.0 1.9 1 0 0 1 1 1 1 C2 domain FYVE PF01363.21 ETO14659.1 - 0.0022 18.1 1.8 0.0056 16.8 1.8 1.7 1 0 0 1 1 1 1 FYVE zinc finger Nudix_N_2 PF14803.6 ETO14659.1 - 3.9 7.5 6.1 0.44 10.5 1.3 2.0 2 0 0 2 2 2 0 Nudix N-terminal COP-gamma_platf PF08752.10 ETO14660.1 - 4.7e-33 114.5 2.2 8.5e-33 113.6 2.2 1.4 1 0 0 1 1 1 1 Coatomer gamma subunit appendage platform subdomain Coatomer_g_Cpla PF16381.5 ETO14660.1 - 3e-13 49.9 0.0 6.2e-13 48.9 0.0 1.5 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform Coatomer_b_Cpla PF14806.6 ETO14660.1 - 0.0003 20.8 0.0 0.0025 17.8 0.0 2.4 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform Atg29_N PF18388.1 ETO14660.1 - 0.098 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Atg29 N-terminal domain Adaptin_N PF01602.20 ETO14661.1 - 2.2e-42 145.3 0.0 2.9e-42 144.9 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 ETO14661.1 - 2.4e-05 24.7 0.0 0.45 10.9 0.0 3.4 2 1 1 3 3 3 3 HEAT repeats HEAT PF02985.22 ETO14661.1 - 0.014 15.6 1.0 1.8 9.0 0.0 3.8 4 0 0 4 4 4 0 HEAT repeat MOR2-PAG1_C PF14225.6 ETO14661.1 - 0.085 12.7 0.1 0.12 12.3 0.1 1.2 1 0 0 1 1 1 0 Cell morphogenesis C-terminal Adaptin_N PF01602.20 ETO14662.1 - 1.6e-34 119.4 0.2 2e-34 119.1 0.2 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cdc6_C PF09079.11 ETO14664.1 - 0.013 15.5 0.0 0.026 14.5 0.0 1.5 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain Phage_min_cap2 PF06152.11 ETO14664.1 - 0.059 12.3 0.7 0.11 11.4 0.6 1.5 2 0 0 2 2 2 0 Phage minor capsid protein 2 CALCOCO1 PF07888.11 ETO14664.1 - 0.19 10.5 0.0 0.27 10.1 0.0 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like NPV_P10 PF05531.12 ETO14664.1 - 0.45 11.0 3.6 2.4 8.7 0.0 2.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein EMC3_TMCO1 PF01956.16 ETO14665.1 - 0.011 15.4 3.7 0.1 12.3 1.0 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like WD40 PF00400.32 ETO14666.1 - 3.8e-54 179.4 13.8 2.4e-10 40.8 0.0 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14666.1 - 6.5e-19 68.0 2.9 1.2e-05 25.5 0.1 4.6 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14666.1 - 3.9e-15 55.6 0.0 0.0089 15.0 0.0 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14666.1 - 9.2e-08 31.8 1.3 0.036 13.4 0.1 3.2 1 1 3 4 4 4 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO14666.1 - 8.5e-05 21.2 0.7 0.14 10.7 0.1 2.9 1 1 4 5 5 5 4 Cytochrome D1 heme domain Nup160 PF11715.8 ETO14666.1 - 0.00013 20.7 5.4 0.67 8.5 0.1 3.8 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO14666.1 - 0.00025 20.9 4.6 8.8 6.4 0.0 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO14666.1 - 0.00028 20.6 0.3 0.021 14.4 0.1 2.2 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region WD40 PF00400.32 ETO14667.1 - 9.6e-49 162.3 12.3 6e-10 39.6 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14667.1 - 9e-18 64.4 1.0 0.0004 20.6 0.0 5.2 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14667.1 - 1.2e-11 44.2 2.9 0.014 14.3 0.2 5.0 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14667.1 - 1.2e-09 38.0 6.5 0.00093 18.6 0.2 3.1 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO14667.1 - 3.4e-05 22.7 5.0 1.1 7.8 0.0 4.4 1 1 3 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO14667.1 - 0.00011 20.9 1.0 0.2 10.1 0.1 2.9 1 1 2 3 3 3 3 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO14667.1 - 0.0011 17.8 0.1 0.0038 16.1 0.1 1.9 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5046 PF16465.5 ETO14667.1 - 0.0041 16.6 0.1 0.12 11.8 0.0 1.9 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) DUF5570 PF17731.1 ETO14667.1 - 0.0043 17.1 1.6 0.2 11.7 0.3 3.0 1 1 2 3 3 3 1 Family of unknown function (DUF5570) SGL PF08450.12 ETO14667.1 - 0.027 14.0 0.1 0.17 11.4 0.1 2.0 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region PQQ PF01011.21 ETO14667.1 - 0.054 13.4 0.0 25 5.0 0.0 4.0 5 1 1 6 6 6 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETO14667.1 - 0.5 10.1 1.3 8.7 6.1 0.0 3.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO14668.1 - 0.067 13.5 2.2 2.8 8.3 0.2 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO14668.1 - 0.15 11.7 2.6 8 6.1 0.3 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO14668.1 - 1.3 9.1 5.3 4.1 7.5 0.2 3.1 3 1 0 3 3 3 0 Kelch motif Lung_7-TM_R PF06814.13 ETO14669.1 - 7.5e-18 64.8 27.6 1.7e-17 63.6 27.6 1.5 1 1 0 1 1 1 1 Lung seven transmembrane receptor DUF3290 PF11694.8 ETO14669.1 - 0.013 15.5 1.4 0.013 15.5 1.4 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3290) Vpu PF00558.19 ETO14669.1 - 0.61 9.9 0.1 0.61 9.9 0.1 2.2 2 0 0 2 2 2 0 Vpu protein PSRP-3_Ycf65 PF04839.13 ETO14670.1 - 0.052 13.7 0.5 0.052 13.7 0.5 1.5 2 0 0 2 2 2 0 Plastid and cyanobacterial ribosomal protein (PSRP-3 / Ycf65) NACHT PF05729.12 ETO14670.1 - 1.9 8.4 3.4 25 4.7 0.2 2.1 1 1 0 2 2 2 0 NACHT domain WD40 PF00400.32 ETO14671.1 - 1.4e-33 114.3 25.7 4e-06 27.4 0.4 7.8 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14671.1 - 1.6e-11 44.3 3.8 0.012 15.9 0.0 6.0 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14671.1 - 1.9e-05 23.5 9.2 1.7 7.2 0.1 5.6 2 2 4 6 6 6 6 Nucleoporin Nup120/160 DUF1644 PF07800.12 ETO14672.1 - 0.005 16.9 3.4 0.0081 16.2 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1644) zf-RING_2 PF13639.6 ETO14672.1 - 0.031 14.6 2.2 0.084 13.2 1.4 2.1 1 1 1 2 2 2 0 Ring finger domain zf-C3HC4_3 PF13920.6 ETO14672.1 - 0.11 12.4 5.5 0.63 9.9 5.5 2.0 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO14672.1 - 1.6 9.1 6.9 0.78 10.1 1.2 2.7 1 1 1 2 2 2 0 RING-like domain TPR_12 PF13424.6 ETO14673.1 - 4.3e-30 103.8 1.5 1e-11 45.0 0.4 4.0 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14673.1 - 4.6e-29 99.4 0.3 9e-09 34.9 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14673.1 - 3.6e-24 83.5 21.6 6.2e-09 35.3 0.6 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14673.1 - 4.2e-24 82.7 15.1 1.6e-07 30.9 0.3 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14673.1 - 2.3e-21 74.2 23.2 3e-08 33.3 1.4 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14673.1 - 3.4e-19 67.4 3.7 1.3e-06 28.0 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO14673.1 - 2e-09 37.5 2.2 0.14 12.9 0.0 5.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14673.1 - 1.6e-08 34.3 11.9 0.13 12.7 0.1 5.4 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14673.1 - 5.4e-08 33.3 0.0 0.16 12.7 0.0 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO14673.1 - 1.8e-05 24.6 12.4 0.47 10.5 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14673.1 - 2.2e-05 24.0 24.3 0.0024 17.5 1.2 5.3 5 2 1 6 6 6 2 TPR repeat ANAPC3 PF12895.7 ETO14673.1 - 2.8e-05 24.3 12.5 0.014 15.6 1.7 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETO14673.1 - 8.2e-05 23.1 0.0 0.37 11.7 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO14673.1 - 0.00017 22.1 0.1 3.9 8.0 0.1 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO14673.1 - 0.00071 19.0 0.0 0.0065 15.9 0.0 2.0 1 1 1 2 2 2 1 MalT-like TPR region TPR_21 PF09976.9 ETO14673.1 - 0.02 14.6 0.9 0.12 12.1 0.2 2.4 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain SNAP PF14938.6 ETO14673.1 - 0.034 13.6 8.7 1.6 8.1 0.9 3.4 2 1 2 4 4 4 0 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO14673.1 - 0.08 12.7 13.8 0.35 10.7 0.4 4.0 2 2 2 4 4 4 0 Domain of unknown function (DUF5113) PPR PF01535.20 ETO14673.1 - 0.25 11.7 10.6 8.1 6.9 0.1 5.1 6 0 0 6 6 4 0 PPR repeat DUF3450 PF11932.8 ETO14673.1 - 1.4 8.2 3.6 3.1 7.0 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3450) MIT PF04212.18 ETO14673.1 - 4.2 7.5 17.1 3.3 7.9 1.4 4.4 5 0 0 5 5 4 0 MIT (microtubule interacting and transport) domain AP3D1 PF06375.11 ETO14674.1 - 0.0032 17.7 20.7 0.0049 17.1 20.7 1.3 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 SR-25 PF10500.9 ETO14674.1 - 0.011 15.4 23.0 0.014 15.1 23.0 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_polI_A34 PF08208.11 ETO14674.1 - 0.044 13.9 23.5 0.047 13.8 23.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 INSIG PF07281.12 ETO14674.1 - 0.2 11.3 2.6 0.28 10.8 2.6 1.4 1 1 0 1 1 1 0 Insulin-induced protein (INSIG) DUF4666 PF15697.5 ETO14674.1 - 0.33 11.7 9.0 0.39 11.4 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) NARP1 PF12569.8 ETO14674.1 - 0.66 8.8 18.0 0.72 8.7 18.0 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 ETO14674.1 - 0.85 7.8 15.8 0.86 7.8 15.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO14674.1 - 1 9.0 11.6 1.1 9.0 11.6 1.1 1 0 0 1 1 1 0 Connexin RR_TM4-6 PF06459.12 ETO14674.1 - 1.3 8.8 17.3 1.3 8.8 17.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_C37 PF05416.12 ETO14674.1 - 1.6 7.1 11.1 1.7 7.0 11.1 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase EOS1 PF12326.8 ETO14674.1 - 1.6 8.6 7.8 1.8 8.5 7.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein YqfQ PF14181.6 ETO14674.1 - 2 8.6 11.7 2.3 8.4 11.7 1.2 1 0 0 1 1 1 0 YqfQ-like protein Coilin_N PF15862.5 ETO14674.1 - 2.1 8.2 19.0 2.7 7.8 19.0 1.4 1 0 0 1 1 1 0 Coilin N-terminus DUF2828 PF11443.8 ETO14674.1 - 4.4 5.3 15.3 4.5 5.3 15.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CLN3 PF02487.17 ETO14674.1 - 4.6 6.2 4.8 4.6 6.2 4.8 1.1 1 0 0 1 1 1 0 CLN3 protein DDHD PF02862.17 ETO14674.1 - 8.2 6.5 11.0 9 6.4 11.0 1.0 1 0 0 1 1 1 0 DDHD domain PPL5 PF18168.1 ETO14674.1 - 8.7 5.5 13.6 11 5.2 13.6 1.2 1 0 0 1 1 1 0 Prim-pol family 5 AAA_11 PF13086.6 ETO14674.1 - 9.8 5.9 14.2 12 5.6 14.2 1.1 1 0 0 1 1 1 0 AAA domain CENP-B_dimeris PF09026.10 ETO14676.1 - 0.017 15.5 1.1 0.017 15.5 1.1 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Tub_N PF16322.5 ETO14676.1 - 0.03 14.7 3.9 0.036 14.5 3.9 1.1 1 0 0 1 1 1 0 Tubby N-terminal GET2 PF08690.10 ETO14676.1 - 0.31 10.7 2.7 0.48 10.0 2.7 1.4 1 1 0 1 1 1 0 GET complex subunit GET2 Radial_spoke PF04712.12 ETO14676.1 - 0.75 8.7 5.5 0.98 8.3 5.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Nucleotid_trans PF03407.16 ETO14677.1 - 5.8e-05 23.2 0.3 8.7e-05 22.6 0.1 1.4 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase zf-C2H2_4 PF13894.6 ETO14680.1 - 3e-05 24.5 56.6 0.012 16.3 2.5 8.1 7 1 1 8 8 8 5 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO14680.1 - 0.024 15.1 62.0 0.025 15.0 2.7 7.5 7 1 1 8 8 8 0 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 ETO14680.1 - 0.03 14.1 5.5 0.03 14.1 5.5 5.9 7 0 0 7 7 7 0 zinc-finger C2H2-type zf-C2H2_8 PF15909.5 ETO14680.1 - 1.2 9.4 26.4 0.65 10.3 11.8 4.3 2 1 2 4 4 4 0 C2H2-type zinc ribbon GTP_EFTU PF00009.27 ETO14681.1 - 7.7e-23 81.1 0.0 9e-23 80.8 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DAHP_synth_1 PF00793.20 ETO14681.1 - 0.027 13.3 0.0 0.033 13.0 0.0 1.1 1 0 0 1 1 1 0 DAHP synthetase I family GTP_EFTU_D2 PF03144.25 ETO14682.1 - 1.3e-05 25.5 0.0 7.7e-05 23.0 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ETO14682.1 - 0.012 15.7 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Elongation Factor G, domain II EFG_C PF00679.24 ETO14683.1 - 3.4e-23 81.5 0.0 5.4e-23 80.8 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 ETO14683.1 - 7.6e-23 80.6 0.0 1.2e-22 79.9 0.0 1.3 1 0 0 1 1 1 1 Elongation factor G, domain IV OTT_1508_deam PF14441.6 ETO14683.1 - 0.11 12.5 0.1 0.22 11.5 0.1 1.4 1 0 0 1 1 1 0 OTT_1508-like deaminase DUF4446 PF14584.6 ETO14684.1 - 0.09 12.8 6.3 0.98 9.4 1.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) RGS PF00615.19 ETO14684.1 - 0.25 11.6 6.1 0.18 12.0 1.0 2.8 3 0 0 3 3 3 0 Regulator of G protein signaling domain Conotoxin PF02950.17 ETO14684.1 - 5.1 8.2 7.8 18 6.5 0.0 3.7 2 1 0 2 2 2 0 Conotoxin HECT PF00632.25 ETO14685.1 - 1.3e-70 238.4 0.1 2.8e-70 237.3 0.1 1.5 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ETO14685.1 - 1.2e-12 48.0 0.6 8.1e-12 45.3 0.2 2.5 2 0 0 2 2 2 1 SPRY domain Laminin_G_3 PF13385.6 ETO14685.1 - 5.6e-12 46.1 0.1 1.6e-11 44.6 0.1 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Tropomodulin PF03250.14 ETO14686.1 - 0.034 14.2 0.9 0.034 14.2 0.9 2.3 2 0 0 2 2 2 0 Tropomodulin DUF755 PF05501.11 ETO14686.1 - 0.13 12.5 38.9 0.039 14.2 6.7 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF755) Leo1 PF04004.13 ETO14687.1 - 0.075 12.9 0.1 0.081 12.8 0.1 1.2 1 0 0 1 1 1 0 Leo1-like protein Med25 PF11232.8 ETO14688.1 - 0.0061 16.5 1.3 0.027 14.5 0.5 2.1 2 0 0 2 2 2 1 Mediator complex subunit 25 PTOV activation and synapsin 2 Trypsin PF00089.26 ETO14690.1 - 2.1e-14 53.9 0.0 2.4e-14 53.7 0.0 1.1 1 0 0 1 1 1 1 Trypsin CDC45 PF02724.14 ETO14692.1 - 0.016 13.6 1.8 0.02 13.2 1.8 1.1 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO14692.1 - 0.018 14.4 5.9 0.026 13.9 5.9 1.1 1 0 0 1 1 1 0 BUD22 ANAPC4_WD40 PF12894.7 ETO14692.1 - 0.11 12.8 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain SDA1 PF05285.12 ETO14692.1 - 0.21 11.0 9.8 0.32 10.4 9.8 1.1 1 0 0 1 1 1 0 SDA1 VP4_2 PF08935.10 ETO14693.1 - 0.0042 17.6 0.7 0.0063 17.1 0.7 1.3 1 0 0 1 1 1 1 Viral protein VP4 subunit PPP4R2 PF09184.11 ETO14696.1 - 3.6e-06 26.8 9.8 5.5e-06 26.2 9.8 1.3 1 0 0 1 1 1 1 PPP4R2 Nop14 PF04147.12 ETO14696.1 - 0.00031 19.1 8.9 0.00041 18.7 8.9 1.2 1 0 0 1 1 1 1 Nop14-like family NOA36 PF06524.12 ETO14696.1 - 0.001 18.5 16.7 0.0015 17.9 16.7 1.3 1 0 0 1 1 1 1 NOA36 protein SDA1 PF05285.12 ETO14696.1 - 0.0033 16.9 10.9 0.0041 16.6 10.9 1.2 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 ETO14696.1 - 0.0046 15.3 8.4 0.0061 14.9 8.4 1.1 1 0 0 1 1 1 1 CDC45-like protein Cwf_Cwc_15 PF04889.12 ETO14696.1 - 0.069 12.9 16.0 0.12 12.1 16.0 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Sigma70_ner PF04546.13 ETO14696.1 - 0.083 12.8 10.4 0.14 12.0 10.4 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region GEN1_C PF18380.1 ETO14696.1 - 0.16 12.9 7.5 0.33 11.9 7.5 1.5 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain Pes-10 PF07149.11 ETO14696.1 - 0.41 9.7 12.2 0.2 10.7 10.0 1.6 2 0 0 2 2 2 0 Pes-10 CDC27 PF09507.10 ETO14696.1 - 0.61 9.4 15.7 0.81 9.0 15.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RXT2_N PF08595.11 ETO14696.1 - 0.73 9.9 11.3 1.4 8.9 11.3 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal BUD22 PF09073.10 ETO14696.1 - 1.2 8.4 14.5 1.5 8.0 14.5 1.1 1 0 0 1 1 1 0 BUD22 YL1 PF05764.13 ETO14696.1 - 4.3 7.4 18.4 9 6.3 18.4 1.4 1 0 0 1 1 1 0 YL1 nuclear protein DUF2076 PF09849.9 ETO14696.1 - 9.1 6.2 11.2 15 5.5 11.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) zf-UBP PF02148.19 ETO14697.1 - 0.0024 18.1 0.1 0.0064 16.8 0.0 1.7 2 0 0 2 2 2 1 Zn-finger in ubiquitin-hydrolases and other protein NLRC4_HD PF17889.1 ETO14697.1 - 0.094 13.1 2.5 5.2 7.5 0.1 2.3 1 1 1 2 2 2 0 NLRC4 helical domain Terminase_4 PF05119.12 ETO14697.1 - 0.1 13.1 0.3 0.65 10.5 0.2 2.2 2 1 0 2 2 2 0 Phage terminase, small subunit Pepdidase_M14_N PF18027.1 ETO14698.1 - 1.5e-12 47.8 0.2 2.6e-12 47.0 0.2 1.4 1 0 0 1 1 1 1 Cytosolic carboxypeptidase N-terminal domain DUF3692 PF12469.8 ETO14698.1 - 0.093 13.0 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 CRISPR-associated protein Annexin PF00191.20 ETO14699.1 - 1.6e-21 76.1 0.1 1.1e-06 28.5 0.1 4.3 4 0 0 4 4 4 4 Annexin tRNA_deacylase PF04414.12 ETO14699.1 - 0.059 12.9 0.2 1.3 8.5 0.0 2.3 2 0 0 2 2 2 0 D-aminoacyl-tRNA deacylase DUF3810 PF12725.7 ETO14700.1 - 0.068 12.5 5.8 0.012 15.0 2.3 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF1539 PF07560.11 ETO14700.1 - 0.13 12.4 6.0 0.17 12.0 5.5 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1539) U1snRNP70_N PF12220.8 ETO14701.1 - 0.027 15.1 2.6 0.19 12.4 1.7 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal PT PF04886.12 ETO14702.1 - 0.0022 17.5 19.3 0.0022 17.5 19.3 1.7 2 0 0 2 2 2 1 PT repeat DUF4448 PF14610.6 ETO14702.1 - 0.012 15.4 0.0 0.022 14.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Rax2 PF12768.7 ETO14702.1 - 0.013 15.0 0.7 0.025 14.1 0.7 1.6 1 1 0 1 1 1 0 Cortical protein marker for cell polarity WD40 PF00400.32 ETO14705.1 - 1.1e-30 105.2 21.6 2.9e-06 27.9 0.5 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO14705.1 - 4e-09 35.7 5.4 0.033 12.9 0.0 5.1 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14705.1 - 3.3e-08 33.7 2.5 0.25 11.7 0.1 5.8 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF4979 PF16351.5 ETO14705.1 - 0.24 11.6 10.5 0.15 12.3 0.9 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4979) Kelch_1 PF01344.25 ETO14707.1 - 0.019 14.5 0.8 0.6 9.7 0.6 2.7 2 1 0 2 2 2 0 Kelch motif hSH3 PF14603.6 ETO14708.1 - 0.027 14.9 0.6 0.88 10.0 0.2 2.4 2 0 0 2 2 2 0 Helically-extended SH3 domain zinc_ribbon_15 PF17032.5 ETO14709.1 - 0.25 12.1 5.3 0.65 10.8 5.3 1.9 1 1 0 1 1 1 0 zinc-ribbon family AdenylateSensor PF16579.5 ETO14709.1 - 0.36 11.3 3.2 0.39 11.2 2.8 1.3 1 1 0 1 1 1 0 Adenylate sensor of SNF1-like protein kinase YojJ PF10372.9 ETO14710.1 - 0.17 12.0 1.3 0.84 9.8 0.1 2.3 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus PTEN_C2 PF10409.9 ETO14711.1 - 1e-12 47.9 1.6 2e-12 47.0 1.6 1.5 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DUF5549 PF17703.1 ETO14711.1 - 0.13 11.9 0.4 0.2 11.3 0.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5549) EMC3_TMCO1 PF01956.16 ETO14712.1 - 0.00048 19.9 7.1 0.00093 19.0 3.1 2.8 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like DUF4834 PF16118.5 ETO14712.1 - 0.023 15.6 0.3 0.023 15.6 0.3 4.2 6 0 0 6 6 5 0 Domain of unknown function (DUF4834) PA26 PF04636.13 ETO14712.1 - 0.026 13.5 13.7 0.78 8.6 10.5 2.3 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) SpoIIIAH PF12685.7 ETO14712.1 - 0.034 14.0 19.7 0.23 11.2 3.3 2.4 2 0 0 2 2 2 0 SpoIIIAH-like protein Ctr PF04145.15 ETO14712.1 - 0.23 12.1 0.1 0.23 12.1 0.1 3.9 3 1 0 3 3 2 0 Ctr copper transporter family Neur_chan_memb PF02932.16 ETO14712.1 - 0.84 9.6 8.3 5.7 6.9 4.8 2.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region MID_MedPIWI PF18296.1 ETO14712.1 - 0.95 9.2 16.5 1.2 8.9 0.1 2.3 2 0 0 2 2 2 0 MID domain of medPIWI CPSF100_C PF13299.6 ETO14712.1 - 1.8 8.7 19.7 1.2 9.3 0.0 2.5 2 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Mem_trans PF03547.18 ETO14712.1 - 1.9 6.8 10.5 1.7 7.0 3.2 2.3 2 0 0 2 2 2 0 Membrane transport protein DUF3987 PF13148.6 ETO14712.1 - 3.1 6.7 9.0 4.8 6.1 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) MCU PF04678.13 ETO14712.1 - 4.4 7.4 12.1 8 6.5 9.3 2.6 2 0 0 2 2 2 0 Mitochondrial calcium uniporter MAS20 PF02064.15 ETO14712.1 - 5.8 7.0 12.7 27 4.8 10.0 2.7 2 0 0 2 2 2 0 MAS20 protein import receptor Peroxin-13_N PF04088.13 ETO14712.1 - 7.3 6.9 11.1 53 4.1 6.7 2.8 2 0 0 2 2 2 0 Peroxin 13, N-terminal region EIIBC-GUT_N PF03612.14 ETO14712.1 - 7.7 6.2 11.1 20 4.9 6.3 2.5 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus RPN1_RPN2_N PF17781.1 ETO14714.1 - 2.9e-06 26.9 0.7 5.5e-06 26.0 0.7 1.4 1 1 0 1 1 1 1 RPN1/RPN2 N-terminal domain TENA_THI-4 PF03070.16 ETO14714.1 - 0.043 13.6 1.2 0.072 12.9 1.2 1.5 1 1 0 1 1 1 0 TENA/THI-4/PQQC family HrpB7 PF09486.10 ETO14714.1 - 0.047 14.1 0.1 0.059 13.8 0.1 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) ZapB PF06005.12 ETO14714.1 - 0.089 13.2 0.0 0.85 10.1 0.0 2.1 1 1 0 1 1 1 0 Cell division protein ZapB CM_2 PF01817.21 ETO14714.1 - 0.09 13.1 0.1 0.48 10.8 0.0 1.9 2 0 0 2 2 2 0 Chorismate mutase type II U-box PF04564.15 ETO14716.1 - 2.7e-06 27.4 0.5 1.2e-05 25.4 0.1 2.3 2 0 0 2 2 2 1 U-box domain CcdB PF01845.17 ETO14716.1 - 0.0027 17.9 1.0 0.01 16.0 1.0 2.0 1 0 0 1 1 1 1 CcdB protein PspA_IM30 PF04012.12 ETO14716.1 - 0.0097 15.5 4.9 0.021 14.4 4.9 1.5 1 0 0 1 1 1 1 PspA/IM30 family Lys PF00062.20 ETO14716.1 - 0.63 10.3 5.7 0.26 11.6 1.3 2.5 3 0 0 3 3 3 0 C-type lysozyme/alpha-lactalbumin family DUF3450 PF11932.8 ETO14716.1 - 1.2 8.4 14.7 2.3 7.4 8.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF745 PF05335.13 ETO14716.1 - 1.3 8.7 5.1 2.7 7.7 5.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Cortex-I_coil PF09304.10 ETO14716.1 - 4.7 7.5 10.2 8.9 6.6 1.7 2.9 2 1 1 3 3 3 0 Cortexillin I, coiled coil Wzz PF02706.15 ETO14716.1 - 7.2 7.0 7.1 4.8 7.6 0.2 3.4 3 0 0 3 3 3 0 Chain length determinant protein GREB1 PF15782.5 ETO14718.1 - 2.1 5.3 10.5 3.2 4.8 10.5 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AA_permease PF00324.21 ETO14719.1 - 3.2e-14 52.4 17.8 1.8e-11 43.3 9.7 2.0 1 1 1 2 2 2 2 Amino acid permease DUF2207 PF09972.9 ETO14719.1 - 3.3e-06 26.1 3.8 0.0025 16.6 0.0 2.1 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) DUF3671 PF12420.8 ETO14719.1 - 0.025 14.6 6.9 0.15 12.1 7.0 2.4 1 1 0 1 1 1 0 Protein of unknown function Prominin PF05478.11 ETO14719.1 - 0.048 11.6 0.1 0.99 7.3 0.0 2.1 2 0 0 2 2 2 0 Prominin Orf78 PF06024.12 ETO14719.1 - 0.44 10.9 0.0 0.44 10.9 0.0 2.7 3 0 0 3 3 3 0 Orf78 (ac78) DHHC PF01529.20 ETO14719.1 - 3.4 7.8 6.3 4.1 7.5 3.9 2.2 1 1 1 2 2 2 0 DHHC palmitoyltransferase FA_desaturase PF00487.24 ETO14719.1 - 3.9 7.2 5.9 23 4.7 0.0 2.1 1 1 0 2 2 2 0 Fatty acid desaturase Connexin PF00029.19 ETO14719.1 - 5.3 6.7 8.4 1.9 8.2 3.3 2.6 2 1 0 2 2 2 0 Connexin DUF3784 PF12650.7 ETO14719.1 - 9 6.6 13.5 19 5.5 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) SLC12 PF03522.15 ETO14720.1 - 3.5e-20 72.5 0.0 4.8e-20 72.0 0.0 1.1 1 0 0 1 1 1 1 Solute carrier family 12 SLC12 PF03522.15 ETO14721.1 - 7.9e-09 35.0 3.2 7.9e-09 35.0 3.2 1.9 1 1 1 2 2 2 1 Solute carrier family 12 Ripply PF14998.6 ETO14721.1 - 0.088 13.5 1.0 0.16 12.7 1.0 1.4 1 0 0 1 1 1 0 Transcription Regulator Ion_trans PF00520.31 ETO14723.1 - 6.5e-05 22.3 2.3 6.5e-05 22.3 2.3 4.3 4 0 0 4 4 4 2 Ion transport protein SPC25 PF06703.11 ETO14723.1 - 4.4 7.1 9.2 0.8 9.5 4.1 2.3 3 0 0 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Glyco_hydro_53 PF07745.13 ETO14726.1 - 5.7e-27 94.6 0.0 4.9e-25 88.2 0.0 2.0 1 1 0 1 1 1 1 Glycosyl hydrolase family 53 Defensin_3 PF08131.11 ETO14726.1 - 0.15 12.3 0.1 0.35 11.1 0.0 1.6 2 0 0 2 2 2 0 Defensin-like peptide family ubiquitin PF00240.23 ETO14727.1 - 6.9e-165 535.1 24.3 1.4e-32 111.3 0.4 5.2 5 0 0 5 5 5 5 Ubiquitin family Rad60-SLD PF11976.8 ETO14727.1 - 3.3e-80 263.9 25.0 1.2e-15 57.1 0.6 5.3 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO14727.1 - 1.4e-29 102.3 10.3 0.00042 20.7 0.1 6.7 5 5 0 5 5 5 5 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO14727.1 - 3.1e-20 71.9 9.4 0.02 14.8 0.1 5.4 5 0 0 5 5 5 5 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO14727.1 - 4e-18 65.5 7.9 0.042 14.0 0.1 5.8 5 0 0 5 5 5 5 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO14727.1 - 7.9e-17 61.4 8.9 0.12 12.7 0.0 5.4 5 0 0 5 5 5 5 Ubiquitin-like domain DUF2407 PF10302.9 ETO14727.1 - 1.1e-15 58.0 2.8 0.46 11.1 0.0 5.3 1 1 1 5 5 5 5 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO14727.1 - 1.4e-08 34.6 18.3 36 4.5 0.1 10.0 10 0 0 10 10 10 0 Ubiquitin-like domain PI3K_rbd PF00794.18 ETO14727.1 - 6.5e-07 29.5 5.6 15 5.8 0.0 5.7 5 0 0 5 5 5 0 PI3-kinase family, ras-binding domain DUF2870 PF11069.8 ETO14727.1 - 1.5e-06 28.5 0.1 33 4.9 0.0 6.1 5 0 0 5 5 5 0 Protein of unknown function (DUF2870) RBD PF02196.15 ETO14727.1 - 1.9e-05 24.7 0.0 80 3.4 0.0 5.3 5 0 0 5 5 5 0 Raf-like Ras-binding domain DUF3379 PF11859.8 ETO14727.1 - 0.00066 19.1 0.7 29 3.9 0.0 4.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3379) DUF4454 PF14628.6 ETO14727.1 - 0.0055 16.6 1.8 85 2.9 0.0 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF4454) ProRS-C_2 PF09181.10 ETO14727.1 - 0.13 12.4 6.8 2.1e+02 2.2 0.0 5.1 5 0 0 5 5 5 0 Prolyl-tRNA synthetase, C-terminal DUF3861 PF12977.7 ETO14727.1 - 0.27 11.4 4.8 3.5e+02 1.4 0.0 5.1 5 0 0 5 5 5 0 Domain of Unknown Function with PDB structure (DUF3861) LBP_C PF17386.2 ETO14727.1 - 0.52 10.2 4.2 3.7e+02 1.1 0.0 4.8 5 0 0 5 5 5 0 Lacto-N-biose phosphorylase C-terminal domain DUF5383 PF17355.2 ETO14727.1 - 0.52 10.7 19.9 85 3.5 0.1 6.7 7 0 0 7 7 7 0 Family of unknown function (DUF5383) FlgD_ig PF13860.6 ETO14727.1 - 1.3 8.9 9.7 1.9e+02 2.0 0.1 5.1 5 0 0 5 5 5 0 FlgD Ig-like domain PI3K_p85B PF02192.16 ETO14727.1 - 2.8 7.8 10.7 1.7e+02 2.0 0.1 5.2 5 0 0 5 5 5 0 PI3-kinase family, p85-binding domain Phage_sheath_1N PF17481.2 ETO14727.1 - 5.8 7.5 8.2 7.7e+02 0.6 0.1 4.6 1 1 1 2 2 2 0 Phage tail sheath protein beta-sandwich domain Pox_EPC_I2-L1 PF12575.8 ETO14727.1 - 7.4 6.9 9.1 0.29 11.4 1.9 2.4 3 0 0 3 3 2 0 Poxvirus entry protein complex L1 and I2 T4_deiodinase PF00837.17 ETO14728.1 - 3e-14 52.9 0.0 3.2e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF4394 PF14339.6 ETO14728.1 - 0.12 11.7 0.0 0.15 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) Ku_C PF03730.14 ETO14729.1 - 9.3e-11 42.3 3.7 6e-10 39.7 3.6 2.2 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm SAP PF02037.27 ETO14729.1 - 1.6e-07 30.9 0.6 1.6e-07 30.9 0.6 2.2 2 0 0 2 2 2 1 SAP domain Telomere_Sde2_2 PF13297.6 ETO14729.1 - 0.024 14.3 0.0 0.057 13.1 0.0 1.6 1 0 0 1 1 1 0 Telomere stability C-terminal Ku PF02735.16 ETO14729.1 - 0.034 13.8 0.1 0.078 12.7 0.0 1.6 2 0 0 2 2 2 0 Ku70/Ku80 beta-barrel domain SMN PF06003.12 ETO14729.1 - 3.2 6.9 6.7 17 4.6 0.0 2.1 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) tRNA-synt_2c PF01411.19 ETO14733.1 - 5.7e-05 21.8 0.4 0.00014 20.5 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetases class II (A) tRNA_SAD PF07973.14 ETO14733.1 - 7.2e-05 22.8 0.7 0.00018 21.5 0.1 2.0 2 0 0 2 2 2 1 Threonyl and Alanyl tRNA synthetase second additional domain PT PF04886.12 ETO14734.1 - 2.5e-32 110.1 788.9 5.7e-08 32.2 18.2 39.5 1 1 20 21 21 21 8 PT repeat Pirin PF02678.16 ETO14735.1 - 3.6e-06 26.9 0.2 6.3e-05 22.9 0.2 2.3 1 1 0 1 1 1 1 Pirin Pirin_C_2 PF17954.1 ETO14735.1 - 1e-05 25.6 0.0 3.8e-05 23.8 0.0 2.0 2 0 0 2 2 2 1 Quercetinase C-terminal cupin domain T3SS_HrpK1 PF16937.5 ETO14735.1 - 0.0021 17.8 0.9 0.003 17.2 0.2 1.6 2 0 0 2 2 2 1 Type III secretion system translocator protein, HrpF PPL5 PF18168.1 ETO14739.1 - 0.013 14.9 2.3 0.016 14.6 2.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF4569 PF15133.6 ETO14739.1 - 0.16 11.6 2.9 0.19 11.4 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Peptidase_A17 PF05380.13 ETO14739.1 - 0.22 11.5 4.8 0.39 10.7 4.8 1.4 1 0 0 1 1 1 0 Pao retrotransposon peptidase DUF4446 PF14584.6 ETO14739.1 - 1.5 8.8 8.6 0.38 10.7 4.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) O-antigen_lig PF13425.6 ETO14739.1 - 4.7 5.9 14.5 0.2 10.4 8.3 1.6 2 0 0 2 2 2 0 O-antigen ligase like membrane protein YabA PF06156.13 ETO14740.1 - 0.25 12.0 23.3 0.47 11.1 4.7 2.7 1 1 2 3 3 3 0 Initiation control protein YabA GAS PF13851.6 ETO14740.1 - 0.29 10.5 27.8 1.8 7.9 2.0 2.7 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 ETO14740.1 - 0.33 11.2 16.5 1.7 9.0 4.9 2.3 1 1 0 2 2 2 0 Uncharacterized conserved protein NACHT_N PF17100.5 ETO14740.1 - 0.45 10.3 12.4 0.033 14.0 3.1 2.1 1 1 0 2 2 2 0 N-terminal domain of NWD NACHT-NTPase Med8 PF10232.9 ETO14740.1 - 0.61 9.6 19.7 0.21 11.1 3.9 3.0 1 1 2 3 3 3 0 Mediator of RNA polymerase II transcription complex subunit 8 rRNA_proc-arch PF13234.6 ETO14740.1 - 0.73 9.7 17.5 2.4 8.0 8.7 2.0 1 1 1 2 2 2 0 rRNA-processing arch domain Spc7 PF08317.11 ETO14740.1 - 0.77 8.6 26.4 0.88 8.4 26.4 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF948 PF06103.11 ETO14740.1 - 1.8 8.9 9.2 13 6.1 9.2 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Prominin PF05478.11 ETO14740.1 - 2.5 5.9 15.3 3.1 5.7 15.3 1.1 1 0 0 1 1 1 0 Prominin Mod_r PF07200.13 ETO14740.1 - 3.8 7.6 26.2 42 4.2 6.2 2.3 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein CENP-H PF05837.12 ETO14740.1 - 4.3 7.8 23.1 4.2 7.8 5.9 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF4407 PF14362.6 ETO14740.1 - 9.4 5.5 11.8 14 5.0 11.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1387 PF07139.11 ETO14741.1 - 0.086 12.6 0.3 0.13 12.0 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) HTH_57 PF18679.1 ETO14743.1 - 1.7 9.0 6.4 3.8 7.9 4.0 2.3 1 1 1 2 2 2 0 ThcOx helix turn helix domain Caldesmon PF02029.15 ETO14743.1 - 1.8 7.2 32.4 2.3 6.9 32.4 1.1 1 0 0 1 1 1 0 Caldesmon SesA PF17107.5 ETO14743.1 - 2.6 8.3 9.5 0.62 10.3 0.3 2.6 2 1 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ETRAMP PF09716.10 ETO14743.1 - 6.1 7.0 11.4 1.9e+02 2.2 11.4 3.2 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO14744.1 - 3e-34 116.5 31.5 1.7e-06 28.6 1.2 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14744.1 - 8.7e-12 45.2 3.6 0.00055 20.2 0.1 5.9 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14744.1 - 1.1e-09 37.5 7.3 0.005 15.6 0.2 5.4 1 1 4 5 5 5 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO14744.1 - 0.00027 21.6 3.0 0.00027 21.6 3.0 3.0 3 0 0 3 3 3 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETO14744.1 - 0.9 9.4 5.2 5 7.0 2.6 3.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DTW PF03942.15 ETO14745.1 - 0.0044 16.8 0.0 0.0058 16.4 0.0 1.2 1 0 0 1 1 1 1 DTW domain Bap31 PF05529.12 ETO14745.1 - 0.025 14.5 0.1 0.054 13.4 0.1 1.5 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region HBD PF18534.1 ETO14745.1 - 0.11 12.6 0.8 2.8 8.1 0.1 2.7 1 1 1 2 2 2 0 Helical bundle domain Imm5 PF14423.6 ETO14747.1 - 0.27 11.5 2.2 1.1 9.5 2.3 1.8 1 1 0 1 1 1 0 Immunity protein Imm5 TPR_2 PF07719.17 ETO14748.1 - 2.4e-12 46.0 16.3 0.013 15.5 0.1 7.0 9 0 0 9 9 8 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETO14748.1 - 1.7e-11 44.5 2.5 0.011 16.2 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14748.1 - 9.8e-10 38.5 13.7 2.4e-06 27.6 2.3 4.5 4 1 0 4 4 4 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_8 PF13181.6 ETO14748.1 - 7.4e-09 35.1 6.3 0.0034 17.5 0.0 5.5 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14748.1 - 2.7e-08 33.6 6.7 0.087 13.2 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14748.1 - 3e-07 30.0 7.9 0.15 11.9 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO14748.1 - 3.1e-07 30.6 0.7 1.6 9.7 0.0 5.3 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14748.1 - 1.4e-05 25.6 0.2 4.5 8.0 0.0 3.9 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO14748.1 - 6.4e-05 23.2 7.2 0.12 12.7 0.0 4.1 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO14748.1 - 0.00015 21.8 0.8 4.5 7.5 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ETO14748.1 - 0.00071 19.2 0.3 4.2 7.0 0.1 3.7 3 1 1 4 4 4 2 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 ETO14748.1 - 0.0016 18.9 3.5 4.6 8.1 0.0 5.5 8 0 0 8 8 5 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO14748.1 - 0.0071 16.6 0.1 0.19 12.1 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14748.1 - 0.018 14.9 4.1 3.2 7.8 0.0 4.1 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO14748.1 - 0.042 13.9 7.0 0.15 12.1 1.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14748.1 - 0.078 12.7 5.1 6.8 6.5 0.0 4.9 4 1 2 6 6 6 0 TPR repeat Acyltransferase PF01553.21 ETO14748.1 - 0.093 12.3 0.0 0.19 11.4 0.0 1.4 1 0 0 1 1 1 0 Acyltransferase TPR_21 PF09976.9 ETO14748.1 - 0.1 12.3 0.5 0.73 9.5 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain SRP_TPR_like PF17004.5 ETO14748.1 - 0.11 12.6 2.1 1.3 9.0 0.1 2.9 2 2 1 3 3 3 0 Putative TPR-like repeat Fis1_TPR_C PF14853.6 ETO14748.1 - 0.45 10.6 6.3 0.99 9.5 1.2 3.2 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETO14749.1 - 2e-05 25.0 4.0 0.16 12.5 0.0 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO14749.1 - 3.5e-05 24.2 3.2 0.67 10.9 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14749.1 - 6.3e-05 22.8 20.9 0.0051 16.8 0.8 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14749.1 - 0.00083 19.5 0.2 0.00083 19.5 0.2 3.4 3 1 0 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ETO14749.1 - 0.0045 17.3 12.5 4.9 7.5 0.2 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14749.1 - 0.0053 17.1 5.1 0.33 11.4 0.0 3.9 4 0 0 4 4 3 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO14749.1 - 0.0054 16.8 0.2 0.039 14.0 0.1 2.5 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 ETO14749.1 - 0.0081 16.0 4.0 10 6.1 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14749.1 - 0.1 13.3 0.2 0.1 13.3 0.2 3.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14749.1 - 0.13 12.5 13.4 7.7 7.0 0.4 4.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14749.1 - 1.2 9.3 6.8 1.9 8.7 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14749.1 - 7.1 6.6 16.5 8.9 6.3 0.7 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat AAA PF00004.29 ETO14750.1 - 3.1e-08 34.1 0.1 2.9e-06 27.7 0.0 2.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO14750.1 - 3.1e-06 27.2 0.0 1.6e-05 24.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 ETO14750.1 - 5.4e-06 25.9 0.1 2.1e-05 24.0 0.1 2.0 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 ETO14750.1 - 2.6e-05 23.8 0.2 0.00013 21.5 0.0 2.3 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_14 PF13173.6 ETO14750.1 - 2.8e-05 24.2 1.5 0.00013 22.0 0.0 3.0 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 ETO14750.1 - 0.00023 21.7 0.0 0.0007 20.1 0.0 1.8 1 0 0 1 1 1 1 ABC transporter DUF815 PF05673.13 ETO14750.1 - 0.00078 18.7 0.1 0.0018 17.5 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ETO14750.1 - 0.0039 17.5 0.3 0.054 13.8 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ETO14750.1 - 0.0043 17.4 0.0 0.19 12.1 0.0 3.2 3 0 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 ETO14750.1 - 0.0086 16.2 0.0 0.029 14.5 0.0 1.9 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) MCM PF00493.23 ETO14750.1 - 0.024 13.8 0.1 0.087 11.9 0.0 2.0 3 0 0 3 3 3 0 MCM P-loop domain RNA_helicase PF00910.22 ETO14750.1 - 0.028 14.8 0.6 0.78 10.2 0.0 3.2 2 0 0 2 2 2 0 RNA helicase NTPase_1 PF03266.15 ETO14750.1 - 0.16 11.9 0.0 2.2 8.2 0.0 2.4 2 0 0 2 2 2 0 NTPase PH PF00169.29 ETO14751.1 - 9e-08 32.6 0.2 9e-08 32.6 0.2 2.7 2 1 0 2 2 2 1 PH domain UreF PF01730.16 ETO14751.1 - 0.17 12.5 0.4 0.68 10.5 0.2 2.0 2 0 0 2 2 2 0 UreF DUF16 PF01519.16 ETO14751.1 - 0.4 11.2 21.9 0.069 13.6 5.6 2.7 1 1 1 2 2 2 0 Protein of unknown function DUF16 Exonuc_VII_L PF02601.15 ETO14751.1 - 2.8 7.4 12.1 4.2 6.8 12.1 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4200 PF13863.6 ETO14751.1 - 5.1 7.5 31.9 0.069 13.6 22.3 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) FapA PF03961.13 ETO14751.1 - 7.4 5.1 20.3 7.1 5.1 15.1 2.8 3 0 0 3 3 3 0 Flagellar Assembly Protein A WD40 PF00400.32 ETO14752.1 - 1.1e-06 29.2 0.0 0.025 15.4 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO14752.1 - 0.035 13.1 0.2 3.3 6.6 0.1 2.2 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein BING4CT PF08149.11 ETO14752.1 - 0.037 13.8 0.0 0.083 12.7 0.0 1.5 1 0 0 1 1 1 0 BING4CT (NUC141) domain ANAPC4_WD40 PF12894.7 ETO14752.1 - 0.075 13.3 0.0 1.6 9.1 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Presenilin PF01080.17 ETO14752.1 - 0.6 8.8 7.9 0.71 8.6 7.9 1.1 1 0 0 1 1 1 0 Presenilin DUF908 PF06012.12 ETO14752.1 - 0.88 8.9 7.8 1.2 8.5 7.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Sec62 PF03839.16 ETO14752.1 - 2.8 7.4 7.9 4.3 6.8 7.9 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 CDC45 PF02724.14 ETO14752.1 - 7.6 4.7 10.9 10 4.3 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Acyltransferase PF01553.21 ETO14754.1 - 0.00086 18.9 0.0 0.0018 17.9 0.0 1.5 1 0 0 1 1 1 1 Acyltransferase Acyltransferase PF01553.21 ETO14755.1 - 0.00035 20.2 0.0 0.00056 19.5 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase Methyltransf_31 PF13847.6 ETO14755.1 - 0.056 13.2 0.0 0.41 10.4 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain DUF3012 PF11216.8 ETO14755.1 - 0.16 12.1 0.2 0.33 11.0 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3012) CDC45 PF02724.14 ETO14758.1 - 0.00079 17.9 16.9 0.00083 17.8 16.9 1.2 1 0 0 1 1 1 1 CDC45-like protein zf-C3HC4 PF00097.25 ETO14758.1 - 0.00082 19.2 3.1 0.0034 17.2 3.1 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CNDH2_C PF16858.5 ETO14758.1 - 0.0028 17.6 10.6 0.0037 17.2 10.6 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nop14 PF04147.12 ETO14758.1 - 0.0041 15.4 18.1 0.0042 15.4 18.1 1.1 1 0 0 1 1 1 1 Nop14-like family IBR PF01485.21 ETO14758.1 - 0.026 14.7 0.3 0.026 14.7 0.3 3.4 2 1 1 3 3 3 0 IBR domain, a half RING-finger domain SLC12 PF03522.15 ETO14758.1 - 0.43 9.5 8.2 0.55 9.2 8.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 PI3K_1B_p101 PF10486.9 ETO14758.1 - 1.5 6.6 9.0 1.8 6.3 9.0 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SAPS PF04499.15 ETO14758.1 - 1.5 7.5 14.6 1.7 7.3 14.6 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein TRAP_alpha PF03896.16 ETO14758.1 - 2.4 7.3 11.1 4.1 6.5 11.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.9 ETO14758.1 - 7.8 5.5 34.8 13 4.8 34.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop53 PF07767.11 ETO14758.1 - 9 5.6 29.0 1.8 7.9 21.9 2.0 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) DUF3439 PF11921.8 ETO14759.1 - 0.024 14.6 6.8 0.051 13.6 6.8 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO14759.1 - 0.027 14.5 16.6 0.05 13.6 16.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein SAM_LFY PF01698.16 ETO14759.1 - 0.031 14.2 0.5 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Floricaula / Leafy protein SAM domain DUF190 PF02641.15 ETO14759.1 - 0.042 14.2 0.4 0.14 12.5 0.4 2.0 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 E3_UbLigase_RBR PF18091.1 ETO14759.1 - 0.046 13.8 5.7 0.44 10.7 0.5 3.0 3 0 0 3 3 3 0 E3 Ubiquitin Ligase RBR C-terminal domain DUF2935 PF11155.8 ETO14759.1 - 0.5 10.7 9.3 0.51 10.7 0.2 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) SSP160 PF06933.11 ETO14759.1 - 0.65 8.1 11.5 0.89 7.7 11.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MGC-24 PF05283.11 ETO14759.1 - 1.4 9.4 9.0 0.39 11.2 5.3 2.0 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Cbl_N PF02262.16 ETO14759.1 - 2.5 8.1 10.1 0.38 10.8 5.6 2.0 2 0 0 2 2 2 0 CBL proto-oncogene N-terminal domain 1 NAD_binding_2 PF03446.15 ETO14759.1 - 3.5 7.8 7.2 1.5 9.0 0.7 2.6 3 1 0 3 3 3 0 NAD binding domain of 6-phosphogluconate dehydrogenase ETC_C1_NDUFA5 PF04716.14 ETO14759.1 - 10 6.0 8.8 1.3 8.9 0.3 3.5 4 1 0 4 4 4 0 ETC complex I subunit conserved region DUF727 PF05303.12 ETO14760.1 - 0.042 13.9 4.1 2.7 8.1 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF727) DUF2778 PF10908.8 ETO14761.1 - 1.6e-14 54.2 1.0 1.3e-13 51.2 1.0 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF2778) ADAM_spacer1 PF05986.14 ETO14761.1 - 0.074 13.1 0.0 0.12 12.4 0.0 1.4 1 1 0 1 1 1 0 ADAM-TS Spacer 1 Aminotran_1_2 PF00155.21 ETO14763.1 - 8.6e-37 127.1 0.0 1.1e-36 126.8 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Alliinase_C PF04864.13 ETO14763.1 - 0.00022 20.2 0.1 0.00039 19.4 0.1 1.4 1 1 0 1 1 1 1 Allinase YajC PF02699.15 ETO14764.1 - 0.19 11.6 2.4 0.29 11.0 0.4 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit Peptidase_M18 PF02127.15 ETO14765.1 - 5.9e-46 157.1 0.3 1.4e-43 149.3 0.3 2.0 1 1 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M18 PF02127.15 ETO14766.1 - 1.7e-55 188.6 0.1 2e-55 188.4 0.1 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Peptidase_M42 PF05343.14 ETO14766.1 - 2.1e-08 33.5 0.0 2.4e-08 33.3 0.0 1.0 1 0 0 1 1 1 1 M42 glutamyl aminopeptidase NAD_binding_8 PF13450.6 ETO14767.1 - 4.5e-11 42.8 0.4 1.1e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ETO14767.1 - 7.6e-09 35.4 0.0 2.4e-08 33.7 0.0 1.7 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase DAO PF01266.24 ETO14767.1 - 1.7e-07 31.1 0.0 2.1e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETO14767.1 - 0.00014 22.3 0.0 0.0003 21.3 0.0 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO14767.1 - 0.0022 17.3 0.0 0.0028 17.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETO14767.1 - 0.0041 17.1 0.0 0.0085 16.1 0.0 1.6 1 0 0 1 1 1 1 FAD-NAD(P)-binding T4BSS_DotH_IcmK PF12293.8 ETO14767.1 - 0.073 12.3 0.0 0.18 11.1 0.0 1.7 2 0 0 2 2 2 0 Putative outer membrane core complex of type IVb secretion FAD_binding_2 PF00890.24 ETO14767.1 - 0.098 11.7 0.0 0.21 10.6 0.0 1.6 2 0 0 2 2 2 0 FAD binding domain AlaDh_PNT_C PF01262.21 ETO14767.1 - 0.11 11.8 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain DUF4875 PF16175.5 ETO14767.1 - 0.12 12.5 0.1 0.8 9.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4875) Gemini_AL1 PF00799.20 ETO14768.1 - 0.019 15.3 0.5 0.026 14.9 0.5 1.2 1 0 0 1 1 1 0 Geminivirus Rep catalytic domain Chibby PF14645.6 ETO14768.1 - 0.022 15.2 0.0 0.03 14.7 0.0 1.2 1 0 0 1 1 1 0 Chibby family DNA_pol_B PF00136.21 ETO14768.1 - 0.023 13.4 0.7 0.028 13.1 0.7 1.1 1 0 0 1 1 1 0 DNA polymerase family B PRiA4_ORF3 PF07929.11 ETO14768.1 - 0.031 14.0 0.2 0.038 13.7 0.2 1.1 1 0 0 1 1 1 0 Plasmid pRiA4b ORF-3-like protein Orthopox_35kD PF02250.15 ETO14769.1 - 0.004 16.9 2.3 0.0098 15.6 0.5 2.3 1 1 1 2 2 2 1 35kD major secreted virus protein FoP_duplication PF13865.6 ETO14770.1 - 1.4e-13 51.1 10.4 1.4e-13 51.1 10.4 2.4 2 1 0 2 2 2 1 C-terminal duplication domain of Friend of PRMT1 Presenilin PF01080.17 ETO14770.1 - 0.00089 18.1 1.5 0.001 17.9 1.5 1.1 1 0 0 1 1 1 1 Presenilin Zip PF02535.22 ETO14770.1 - 0.065 12.4 1.9 0.088 12.0 1.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 ETO14770.1 - 0.074 12.1 6.1 0.087 11.8 6.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PigN PF04987.14 ETO14770.1 - 0.079 11.8 2.0 0.1 11.4 2.0 1.4 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) RR_TM4-6 PF06459.12 ETO14770.1 - 0.83 9.4 11.0 1.1 9.1 11.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF3122 PF11320.8 ETO14771.1 - 0.088 12.9 1.0 5.5 7.1 0.1 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF3122) Ribonuc_P_40 PF08584.11 ETO14772.1 - 0.042 13.1 1.7 0.048 12.9 1.7 1.1 1 0 0 1 1 1 0 Ribonuclease P 40kDa (Rpp40) subunit DUF4228 PF14009.6 ETO14773.1 - 0.00039 20.9 0.1 0.00047 20.6 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4228) THOC2_N PF16134.5 ETO14773.1 - 0.00081 18.2 0.1 0.00081 18.2 0.1 1.4 2 0 0 2 2 2 1 THO complex subunit 2 N-terminus Sec62 PF03839.16 ETO14773.1 - 0.0082 15.7 10.6 0.012 15.1 10.6 1.2 1 0 0 1 1 1 1 Translocation protein Sec62 CLN3 PF02487.17 ETO14773.1 - 0.017 14.2 2.5 0.028 13.5 2.5 1.4 1 0 0 1 1 1 0 CLN3 protein MCM_bind PF09739.9 ETO14773.1 - 0.027 12.9 3.6 0.034 12.6 3.6 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Zip PF02535.22 ETO14773.1 - 0.033 13.4 0.0 0.034 13.4 0.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Afi1 PF07792.12 ETO14773.1 - 0.037 14.5 2.8 0.07 13.6 2.8 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2828 PF11443.8 ETO14773.1 - 0.082 11.0 8.4 0.099 10.7 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) MMM1 PF10296.9 ETO14773.1 - 0.088 11.9 5.6 0.12 11.4 5.6 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Neur_chan_memb PF02932.16 ETO14773.1 - 0.12 12.4 1.4 0.15 12.1 1.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EOS1 PF12326.8 ETO14773.1 - 0.28 11.1 2.1 0.39 10.6 2.1 1.3 1 0 0 1 1 1 0 N-glycosylation protein Peroxin-13_N PF04088.13 ETO14773.1 - 2.1 8.6 7.0 3.9 7.7 7.0 1.5 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Peptidase_C14 PF00656.22 ETO14774.1 - 1.1e-12 48.5 0.4 3.7e-12 46.7 0.4 1.9 1 1 0 1 1 1 1 Caspase domain Kelch_6 PF13964.6 ETO14774.1 - 1e-10 41.5 4.3 0.00011 22.4 0.0 4.4 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 ETO14774.1 - 1e-09 37.8 0.1 0.00094 18.7 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO14774.1 - 2.6e-09 36.8 0.1 0.0023 17.9 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO14774.1 - 1.1e-05 25.3 0.1 0.0021 18.0 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14774.1 - 0.00019 21.3 1.1 1.5 8.9 0.1 5.0 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO14774.1 - 0.00027 21.2 0.0 0.0034 17.6 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain GrlR PF16518.5 ETO14774.1 - 0.053 13.5 0.0 12 5.9 0.0 2.3 2 0 0 2 2 2 0 T3SS negative regulator,GrlR DUF4805 PF16063.5 ETO14775.1 - 0.56 9.5 6.5 0.43 9.9 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4805) SNF2_N PF00176.23 ETO14776.1 - 2.2e-57 194.4 0.8 4.6e-57 193.3 0.8 1.4 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO14776.1 - 4.3e-20 72.1 0.0 4e-19 69.0 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain HDA2-3 PF11496.8 ETO14776.1 - 1.7e-08 34.0 0.3 1.7e-08 34.0 0.3 2.0 2 0 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 ResIII PF04851.15 ETO14776.1 - 7.3e-08 32.6 0.0 7.3e-08 32.6 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO14776.1 - 0.013 15.3 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase NOA36 PF06524.12 ETO14776.1 - 0.018 14.4 5.8 0.027 13.8 5.8 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2052 PF09747.9 ETO14776.1 - 0.019 15.1 5.4 0.046 13.8 5.4 1.6 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CENP-B_dimeris PF09026.10 ETO14776.1 - 0.028 14.8 3.3 0.077 13.4 3.3 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO14776.1 - 0.11 12.2 2.9 0.24 11.0 2.9 1.6 1 0 0 1 1 1 0 FAM176 family DUF3245 PF11595.8 ETO14776.1 - 0.46 11.0 7.5 1.5 9.3 7.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) Sporozoite_P67 PF05642.11 ETO14776.1 - 2.9 5.9 4.9 4.2 5.3 4.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Ribosomal_60s PF00428.19 ETO14776.1 - 6.9 7.3 10.0 17 6.1 10.0 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein PHD PF00628.29 ETO14777.1 - 0.00057 19.7 6.9 0.00057 19.7 6.9 2.2 2 0 0 2 2 2 1 PHD-finger PHF5 PF03660.14 ETO14777.1 - 0.034 14.3 0.8 0.093 12.9 0.8 1.7 1 0 0 1 1 1 0 PHF5-like protein DUF4710 PF15828.5 ETO14777.1 - 6.3 7.0 16.6 0.091 12.9 1.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4710) UAA PF08449.11 ETO14778.1 - 2e-42 145.5 22.2 3.9e-42 144.5 22.2 1.4 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO14778.1 - 0.0069 16.6 35.6 0.0072 16.5 1.3 4.6 5 0 0 5 5 5 2 EamA-like transporter family 2OG-FeII_Oxy_3 PF13640.6 ETO14779.1 - 0.014 16.2 0.0 0.031 15.1 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Arm PF00514.23 ETO14780.1 - 6.8e-33 111.7 6.4 8.2e-08 32.0 0.0 7.4 8 0 0 8 8 8 5 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETO14780.1 - 4e-10 39.9 0.0 5.4e-05 23.5 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 ETO14780.1 - 3.3e-09 37.0 0.2 0.13 12.8 0.0 4.8 5 0 0 5 5 5 3 HEAT-like repeat HEAT PF02985.22 ETO14780.1 - 0.0013 18.8 0.4 1.9 8.9 0.0 4.5 5 0 0 5 5 5 1 HEAT repeat Cnd1 PF12717.7 ETO14780.1 - 0.08 13.0 0.7 0.2 11.7 0.1 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 AMP-binding PF00501.28 ETO14781.1 - 7.7e-23 80.8 0.0 4.8e-21 74.8 0.0 2.3 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO14781.1 - 1.8e-10 41.6 0.0 3.4e-10 40.8 0.0 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DNA_pol3_delta PF06144.13 ETO14781.1 - 0.13 12.1 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Kelch_6 PF13964.6 ETO14782.1 - 5.6e-10 39.2 1.7 0.00051 20.2 0.1 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO14782.1 - 8.3e-08 32.1 0.1 6.2e-05 22.9 0.0 3.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14782.1 - 5.6e-07 29.3 1.8 0.0061 16.5 0.1 4.4 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO14782.1 - 1.3e-06 27.9 0.2 0.017 14.7 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO14782.1 - 9.1e-06 25.5 0.0 0.015 15.3 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO14782.1 - 0.025 14.9 0.0 0.2 12.0 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Vac17 PF17321.2 ETO14782.1 - 0.05 13.0 0.2 0.081 12.4 0.2 1.3 1 0 0 1 1 1 0 Vacuole-related protein 17 Neuromodulin_N PF10580.9 ETO14783.1 - 0.15 11.9 1.9 0.25 11.2 1.9 1.3 1 0 0 1 1 1 0 Gap junction protein N-terminal region FAM176 PF14851.6 ETO14784.1 - 0.19 11.4 7.4 2.2 7.9 2.1 2.4 2 0 0 2 2 2 0 FAM176 family CAC1F_C PF16885.5 ETO14784.1 - 0.2 11.3 9.8 0.27 10.9 9.8 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Connexin PF00029.19 ETO14784.1 - 3.3 7.4 5.7 3 7.5 0.9 2.1 2 0 0 2 2 2 0 Connexin TPR_12 PF13424.6 ETO14786.1 - 8e-54 179.9 15.5 5.6e-14 52.2 1.4 4.4 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14786.1 - 6.2e-35 118.1 0.6 1.1e-08 34.6 0.0 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14786.1 - 2.2e-30 103.2 34.1 5.8e-08 32.2 1.1 6.7 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14786.1 - 3e-29 98.9 2.7 1.3e-05 24.9 0.0 6.0 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO14786.1 - 5.6e-21 72.9 22.0 1.8e-06 27.6 0.4 6.9 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14786.1 - 1.2e-20 71.9 31.5 6.6e-07 29.1 1.1 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO14786.1 - 9.8e-07 28.4 20.4 0.0078 15.9 0.4 6.1 6 1 0 6 6 6 3 TPR repeat TPR_17 PF13431.6 ETO14786.1 - 1.8e-06 27.9 17.1 0.4 11.2 0.7 6.6 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO14786.1 - 2.3e-05 23.9 0.0 0.05 13.0 0.0 2.5 1 1 2 3 3 3 2 MalT-like TPR region DUF2225 PF09986.9 ETO14786.1 - 0.00013 21.8 16.6 0.091 12.5 0.2 4.1 1 1 3 4 4 4 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_14 PF13428.6 ETO14786.1 - 0.00033 21.2 0.0 22 6.2 0.0 5.3 3 2 1 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO14786.1 - 0.0027 18.3 0.0 8.1 7.2 0.0 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO14786.1 - 0.038 14.0 0.8 0.038 14.0 0.8 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO14786.1 - 0.1 13.3 3.9 14 6.5 0.0 4.8 6 0 0 6 6 5 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO14786.1 - 0.15 11.6 1.1 19 4.8 0.0 3.7 3 0 0 3 3 3 0 SHNi-TPR Fer4_12 PF13353.6 ETO14786.1 - 0.16 12.3 3.3 0.44 10.8 0.4 3.2 2 1 1 3 3 3 0 4Fe-4S single cluster domain DUF5113 PF17140.4 ETO14786.1 - 0.86 9.4 26.1 0.48 10.2 0.9 5.9 4 2 2 6 6 6 0 Domain of unknown function (DUF5113) PPR PF01535.20 ETO14786.1 - 8.9 6.8 7.0 70 4.0 0.1 4.6 5 0 0 5 5 4 0 PPR repeat Pkinase PF00069.25 ETO14788.1 - 5.6e-37 127.5 0.0 6.1e-25 88.1 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO14788.1 - 3.3e-24 85.6 0.0 4.8e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase SelP_N PF04592.14 ETO14788.1 - 0.21 11.0 12.7 0.32 10.4 12.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 ETO14788.1 - 0.23 10.7 2.8 0.27 10.4 2.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Pkinase PF00069.25 ETO14789.1 - 0.007 15.8 0.0 0.007 15.8 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain ASD2 PF08687.11 ETO14789.1 - 2.9 7.4 6.0 1 8.8 3.0 1.7 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Ureide_permease PF07168.11 ETO14789.1 - 4.9 5.8 6.3 7.9 5.1 6.3 1.2 1 0 0 1 1 1 0 Ureide permease DUF2076 PF09849.9 ETO14789.1 - 6.5 6.7 19.3 12 5.9 19.3 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) XhlA PF10779.9 ETO14790.1 - 2 8.7 9.5 0.12 12.6 1.8 2.7 2 0 0 2 2 2 0 Haemolysin XhlA RTTN_N PF14726.6 ETO14791.1 - 0.083 13.7 0.0 0.13 13.1 0.0 1.3 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning GYF_2 PF14237.6 ETO14792.1 - 1.4e-07 31.2 0.1 3.3e-07 30.0 0.1 1.7 1 0 0 1 1 1 1 GYF domain 2 Cyc-maltodext_C PF10438.9 ETO14792.1 - 0.2 11.8 1.2 0.69 10.1 0.0 2.2 2 1 1 3 3 3 0 Cyclo-malto-dextrinase C-terminal domain Metallophos PF00149.28 ETO14793.1 - 4.1e-33 115.6 0.0 8.4e-19 68.9 0.0 2.2 2 0 0 2 2 2 2 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO14793.1 - 1.4e-17 63.9 0.8 3.1e-17 62.8 0.8 1.6 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Terminase_6C PF17289.2 ETO14794.1 - 0.016 15.3 0.1 0.041 14.0 0.1 1.7 1 0 0 1 1 1 0 Terminase RNaseH-like domain Ank_2 PF12796.7 ETO14794.1 - 0.027 15.0 0.4 0.65 10.6 0.1 3.0 2 1 0 3 3 3 0 Ankyrin repeats (3 copies) DUF5049 PF16468.5 ETO14794.1 - 0.08 12.9 0.0 0.26 11.2 0.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5049) Ank_4 PF13637.6 ETO14794.1 - 0.16 12.6 0.0 4.8 7.9 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) LRRNT_2 PF08263.12 ETO14795.1 - 0.0067 16.7 0.2 0.013 15.8 0.2 1.5 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 ETO14796.1 - 4.4e-13 49.2 13.2 0.0056 17.1 0.2 4.3 1 1 2 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO14796.1 - 2.5e-11 43.2 10.2 1.9e-08 33.9 1.6 3.1 1 1 2 3 3 3 2 Leucine rich repeat LRR_1 PF00560.33 ETO14796.1 - 0.00079 19.6 9.4 0.86 10.4 0.1 4.2 4 1 0 4 4 4 3 Leucine Rich Repeat LRR_6 PF13516.6 ETO14796.1 - 0.051 13.7 7.3 1.2 9.3 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeat DNA_ligase_A_M PF01068.21 ETO14798.1 - 4.5e-20 72.2 0.2 9.2e-20 71.1 0.2 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain BRCT_2 PF16589.5 ETO14798.1 - 2.5e-16 59.9 3.5 1.7e-09 38.0 0.1 3.5 2 1 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain DNA_ligase_A_C PF04679.15 ETO14798.1 - 2.2e-15 57.1 0.0 5.1e-15 55.9 0.0 1.7 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region BRCT PF00533.26 ETO14798.1 - 2.5e-08 34.2 3.4 0.0017 18.7 0.1 3.2 3 1 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain DNA_ligase_IV PF11411.8 ETO14798.1 - 5.8e-08 32.7 1.9 1.2e-07 31.7 1.9 1.6 1 0 0 1 1 1 1 DNA ligase IV RNA_ligase PF09414.10 ETO14798.1 - 1.9e-05 25.0 0.2 6.5e-05 23.3 0.0 2.0 2 1 0 2 2 2 1 RNA ligase PTCB-BRCT PF12738.7 ETO14798.1 - 4.4e-05 23.4 0.0 0.058 13.4 0.0 2.7 2 0 0 2 2 2 2 twin BRCT domain mRNA_cap_enzyme PF01331.19 ETO14798.1 - 0.012 15.5 0.1 0.034 14.0 0.1 1.8 1 0 0 1 1 1 0 mRNA capping enzyme, catalytic domain Phos_pyr_kin PF08543.12 ETO14798.1 - 0.05 13.0 0.1 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 Phosphomethylpyrimidine kinase DNA_ligase_A_N PF04675.14 ETO14799.1 - 5.3e-32 111.5 0.2 1.2e-31 110.4 0.0 1.7 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 ETO14799.1 - 4.3e-16 59.2 0.8 4.3e-16 59.2 0.8 1.7 2 0 0 2 2 2 1 ATP dependent DNA ligase domain RNA_ligase PF09414.10 ETO14799.1 - 0.039 14.3 2.3 0.049 14.0 0.9 1.9 2 0 0 2 2 2 0 RNA ligase His_kinase PF06580.13 ETO14799.1 - 0.26 11.6 4.1 0.71 10.2 0.5 3.0 2 1 1 3 3 3 0 Histidine kinase Metallophos_2 PF12850.7 ETO14800.1 - 4.6e-18 66.0 0.1 5.7e-18 65.6 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos PF00149.28 ETO14800.1 - 0.0018 18.8 0.5 0.018 15.5 0.5 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase IRK_C PF17655.1 ETO14801.1 - 2.5e-19 69.5 0.0 3.2e-19 69.2 0.0 1.3 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain CdiI_N PF18228.1 ETO14801.1 - 0.041 13.7 0.3 0.071 13.0 0.3 1.4 1 0 0 1 1 1 0 CdiI N-terminal domain ETC_C1_NDUFA5 PF04716.14 ETO14801.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 ETC complex I subunit conserved region Treacle PF03546.14 ETO14802.1 - 1.3 7.8 3.9 0.52 9.1 0.6 1.8 2 0 0 2 2 2 0 Treacher Collins syndrome protein Treacle WD40 PF00400.32 ETO14803.1 - 2.6e-67 221.1 26.0 2.9e-10 40.6 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14803.1 - 6.7e-23 80.8 3.3 0.0011 19.3 0.1 6.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14803.1 - 1.3e-19 70.4 0.2 0.0057 15.7 0.0 6.5 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO14803.1 - 1.5e-08 34.3 0.1 0.0043 16.4 0.1 4.0 1 1 3 4 4 4 2 WD40-like domain DUF5570 PF17731.1 ETO14803.1 - 5.1e-08 33.1 4.0 1.4 9.0 0.0 5.4 1 1 4 5 5 5 3 Family of unknown function (DUF5570) Nup160 PF11715.8 ETO14803.1 - 5.2e-08 32.0 6.3 0.28 9.8 0.3 5.2 1 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO14803.1 - 2e-05 24.4 9.6 9.2 6.3 0.1 5.9 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO14803.1 - 0.0002 20.8 2.6 2.1 7.6 0.1 4.9 1 1 4 6 6 6 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO14803.1 - 0.00098 17.8 0.6 1.8 7.0 0.0 3.3 1 1 2 4 4 4 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO14803.1 - 0.03 13.1 0.1 4.4 6.0 0.0 3.2 2 1 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Resistin PF06954.11 ETO14803.1 - 0.14 12.7 0.4 14 6.3 0.0 3.8 3 1 2 5 5 4 0 Resistin DUF4999 PF16390.5 ETO14803.1 - 0.2 11.9 3.4 58 4.0 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO14803.1 - 1 9.1 11.1 31 4.4 0.0 5.5 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature RGS PF00615.19 ETO14805.1 - 1.5e-23 83.3 0.9 1.5e-23 83.3 0.9 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain Enolase_N PF03952.16 ETO14805.1 - 7e-23 81.2 0.1 1.7e-22 80.0 0.1 1.6 1 0 0 1 1 1 1 Enolase, N-terminal domain cNMP_binding PF00027.29 ETO14805.1 - 0.02 14.9 0.0 0.84 9.8 0.0 2.4 2 0 0 2 2 2 0 Cyclic nucleotide-binding domain Enolase_C PF00113.22 ETO14807.1 - 1.4e-100 336.3 0.1 1.6e-100 336.2 0.1 1.0 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain MR_MLE_C PF13378.6 ETO14807.1 - 1.9e-06 27.6 0.0 2.4e-06 27.3 0.0 1.2 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ETO14807.1 - 1.5e-05 24.3 0.2 2.1e-05 23.8 0.2 1.1 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus Enolase_C PF00113.22 ETO14808.1 - 1.7e-29 103.0 1.4 1.9e-28 99.6 1.4 2.0 1 1 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ETO14808.1 - 5.8e-18 65.3 0.0 1.1e-17 64.5 0.0 1.4 1 0 0 1 1 1 1 Enolase, N-terminal domain Peptidase_C39 PF03412.15 ETO14811.1 - 0.079 12.8 1.4 0.14 11.9 0.4 2.0 2 0 0 2 2 2 0 Peptidase C39 family SmpB PF01668.18 ETO14811.1 - 0.08 12.8 2.6 0.16 11.8 2.6 1.5 1 0 0 1 1 1 0 SmpB protein RasGAP PF00616.19 ETO14812.1 - 3.1e-27 95.7 5.1 3.1e-27 95.7 5.1 1.8 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase E2F_TDP PF02319.20 ETO14812.1 - 0.014 15.4 0.0 0.036 14.1 0.0 1.6 1 0 0 1 1 1 0 E2F/DP family winged-helix DNA-binding domain IL32 PF15225.6 ETO14812.1 - 0.021 15.2 0.0 0.28 11.6 0.0 2.2 2 0 0 2 2 2 0 Interleukin 32 DUF2439 PF10382.9 ETO14812.1 - 0.5 10.7 4.4 6.2 7.2 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) Innate_immun PF12782.7 ETO14813.1 - 0.21 11.1 20.0 0.32 10.5 20.0 1.2 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family XRN_M PF17846.1 ETO14813.1 - 0.29 10.0 13.0 0.056 12.4 7.9 1.9 2 0 0 2 2 2 0 Xrn1 helical domain NicO PF03824.16 ETO14813.1 - 2.2 7.6 7.2 3.6 6.9 7.2 1.5 1 0 0 1 1 1 0 High-affinity nickel-transport protein CCDC71L PF15374.6 ETO14813.1 - 4.1 6.6 9.2 7.8 5.7 9.2 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L RAB3GAP2_N PF14655.6 ETO14814.1 - 8.3e-07 28.6 1.5 1.2e-06 28.0 1.5 1.2 1 1 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus SUIM_assoc PF16619.5 ETO14814.1 - 0.0014 18.7 2.7 0.0024 17.9 2.7 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF1985 PF09331.11 ETO14816.1 - 0.55 10.2 4.5 1.5 8.8 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1985) fn3 PF00041.21 ETO14818.1 - 6.9e-07 29.5 1.8 0.17 12.2 0.1 3.6 3 1 0 3 3 3 2 Fibronectin type III domain DUF1262 PF06880.11 ETO14818.1 - 0.093 13.2 0.2 0.34 11.4 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1262) DUF5081 PF16887.5 ETO14820.1 - 0.27 10.3 3.0 1.7 7.7 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5081) LMBR1 PF04791.16 ETO14821.1 - 1.6 7.6 10.0 1.7 7.4 10.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Fib_alpha PF08702.10 ETO14822.1 - 0.78 9.9 8.3 2.4 8.4 8.3 1.9 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family BAAT_C PF08840.11 ETO14822.1 - 2.9 7.8 8.4 0.64 9.9 1.8 2.9 3 1 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal DUF848 PF05852.11 ETO14822.1 - 8.2 6.5 13.9 1.1 9.4 8.2 2.2 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) ATHILA PF03078.15 ETO14823.1 - 0.012 14.5 0.4 0.015 14.1 0.4 1.1 1 0 0 1 1 1 0 ATHILA ORF-1 family Tn7_Tnp_TnsA_N PF08722.11 ETO14823.1 - 0.066 13.4 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 TnsA endonuclease N terminal Casc1_N PF15927.5 ETO14825.1 - 0.027 14.2 0.2 0.055 13.2 0.1 1.7 1 1 1 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Meis_PKNOX_N PF16493.5 ETO14825.1 - 0.07 13.5 1.0 0.16 12.4 1.0 1.6 1 0 0 1 1 1 0 N-terminal of Homeobox Meis and PKNOX1 Ras PF00071.22 ETO14826.1 - 1e-14 54.5 0.5 1.9e-12 47.1 0.5 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO14826.1 - 6.8e-09 36.0 0.6 2.3e-08 34.2 0.0 2.1 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO14826.1 - 0.022 14.2 0.2 0.083 12.3 0.0 1.9 1 1 1 3 3 3 0 ADP-ribosylation factor family zf-like PF04071.12 ETO14826.1 - 0.035 14.0 0.2 0.064 13.2 0.1 1.5 1 1 0 1 1 1 0 Cysteine-rich small domain Glyco_transf_7N PF13733.6 ETO14829.1 - 0.074 12.7 0.3 0.47 10.1 0.0 2.2 2 0 0 2 2 2 0 N-terminal region of glycosyl transferase group 7 SAP PF02037.27 ETO14830.1 - 0.0068 16.1 0.2 0.0068 16.1 0.2 2.6 3 0 0 3 3 3 1 SAP domain Det1 PF09737.9 ETO14830.1 - 0.11 11.5 0.0 0.16 11.0 0.0 1.1 1 0 0 1 1 1 0 De-etiolated protein 1 Det1 Sina PF03145.16 ETO14831.1 - 1.2e-05 25.4 7.6 1.2e-05 25.4 7.6 2.9 2 1 1 3 3 3 2 Seven in absentia protein family Kelch_6 PF13964.6 ETO14832.1 - 2.6e-05 24.3 1.5 1.6 9.2 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO14832.1 - 5.2e-05 22.7 0.7 0.11 12.1 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO14832.1 - 0.00069 19.5 0.7 2.2 8.4 0.0 3.9 3 0 0 3 3 3 2 Kelch motif NiFe_hyd_SSU_C PF14720.6 ETO14832.1 - 0.093 13.1 0.7 13 6.2 0.0 2.8 3 0 0 3 3 3 0 NiFe/NiFeSe hydrogenase small subunit C-terminal Apis_Csd PF11671.8 ETO14834.1 - 0.0026 17.8 5.1 0.0042 17.1 5.1 1.4 1 0 0 1 1 1 1 Complementary sex determiner protein DUF1168 PF06658.12 ETO14834.1 - 0.011 15.5 13.3 0.016 15.0 13.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DDHD PF02862.17 ETO14834.1 - 0.012 15.8 3.7 0.015 15.5 3.7 1.1 1 0 0 1 1 1 0 DDHD domain DUF3464 PF11947.8 ETO14834.1 - 0.015 15.0 1.4 0.024 14.4 0.9 1.5 1 1 0 1 1 1 0 Photosynthesis affected mutant 68 Ureide_permease PF07168.11 ETO14834.1 - 0.022 13.5 0.5 0.032 13.0 0.5 1.3 1 0 0 1 1 1 0 Ureide permease CSG2 PF16965.5 ETO14834.1 - 0.033 13.2 0.9 0.057 12.4 0.4 1.5 1 1 0 1 1 1 0 Ceramide synthase regulator zf-RING_UBOX PF13445.6 ETO14834.1 - 0.17 12.0 0.6 0.32 11.0 0.0 1.7 2 0 0 2 2 2 0 RING-type zinc-finger Peptidase_S49_N PF08496.10 ETO14834.1 - 0.45 10.6 2.6 0.77 9.8 2.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PBP1_TM PF14812.6 ETO14834.1 - 1.8 9.0 13.9 0.55 10.6 9.1 2.2 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO14834.1 - 3.4 6.9 17.6 4.4 6.5 17.6 1.1 1 0 0 1 1 1 0 NOA36 protein Peptidase_S8 PF00082.22 ETO14835.1 - 2.1e-06 27.2 0.0 2.9e-06 26.8 0.0 1.2 1 0 0 1 1 1 1 Subtilase family RPEL PF02755.15 ETO14836.1 - 0.0004 20.0 0.1 0.75 9.6 0.0 3.2 2 0 0 2 2 2 2 RPEL repeat FAM184 PF15665.5 ETO14836.1 - 0.5 10.1 61.9 3.6 7.3 43.0 3.5 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B ZYG-11_interact PF05884.12 ETO14836.1 - 3.1 7.1 20.2 0.24 10.8 4.4 3.1 1 1 1 3 3 3 0 Interactor of ZYG-11 EF-hand_6 PF13405.6 ETO14837.1 - 1.1e-05 24.9 7.8 0.025 14.5 0.1 3.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO14837.1 - 4.2e-05 23.9 12.3 0.0006 20.2 4.9 3.4 1 1 2 3 3 3 3 EF-hand domain pair Lar_N PF09861.9 ETO14837.1 - 0.00069 18.8 0.0 0.0012 18.1 0.0 1.3 1 0 0 1 1 1 1 Lactate racemase N-terminal domain EF-hand_8 PF13833.6 ETO14837.1 - 0.0032 17.3 11.5 0.12 12.2 1.0 3.5 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO14837.1 - 0.0036 16.7 6.6 0.46 10.1 0.1 3.3 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 ETO14837.1 - 0.017 14.6 18.7 0.029 13.9 0.3 4.5 5 0 0 5 5 5 0 EF hand Caleosin PF05042.13 ETO14837.1 - 0.13 12.2 6.3 5.3 6.9 0.1 3.4 1 1 3 4 4 4 0 Caleosin related protein ZZ PF00569.17 ETO14837.1 - 0.77 9.6 6.7 2.1 8.3 6.7 1.8 1 1 0 1 1 1 0 Zinc finger, ZZ type YacG PF03884.14 ETO14837.1 - 6 6.7 9.5 16 5.3 0.2 2.5 2 0 0 2 2 2 0 DNA gyrase inhibitor YacG WD40 PF00400.32 ETO14838.1 - 1.6e-27 95.1 0.6 1.3e-09 38.5 0.6 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14838.1 - 2e-10 40.8 0.1 0.022 15.1 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14838.1 - 2.1e-06 27.0 0.0 0.43 9.5 0.0 3.1 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO14838.1 - 7e-05 21.7 0.1 1 8.0 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Mid2 PF04478.12 ETO14838.1 - 0.0041 17.0 0.0 0.55 10.1 0.1 2.3 1 1 1 2 2 2 2 Mid2 like cell wall stress sensor WD40 PF00400.32 ETO14839.1 - 3.5e-49 163.7 17.6 2.9e-10 40.5 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14839.1 - 7.1e-22 77.5 4.4 1e-05 25.7 0.1 6.6 2 1 4 7 7 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO14839.1 - 3.5e-16 59.1 1.1 0.012 14.6 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO14839.1 - 2e-11 44.1 1.3 0.00017 21.5 0.2 3.7 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO14839.1 - 4.8e-08 32.7 2.8 0.0045 16.4 0.0 3.7 1 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO14839.1 - 9.8e-08 31.7 0.5 2.8 8.0 0.0 5.9 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO14839.1 - 7e-05 22.3 1.5 0.53 9.6 0.0 4.7 1 1 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO14839.1 - 0.00034 19.3 0.1 0.0088 14.6 0.0 2.6 1 1 1 2 2 2 1 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO14839.1 - 0.00058 19.5 3.2 0.29 10.9 0.0 4.5 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature DUF1513 PF07433.11 ETO14839.1 - 0.02 14.0 0.0 0.45 9.6 0.0 2.9 1 1 3 5 5 5 0 Protein of unknown function (DUF1513) DUF5570 PF17731.1 ETO14839.1 - 0.034 14.3 1.0 8.2 6.6 0.0 3.4 2 1 1 4 4 4 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO14841.1 - 3.5e-11 43.5 3.8 0.0001 23.0 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14841.1 - 0.02 15.2 0.1 27 5.1 0.0 3.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ETO14841.1 - 0.15 12.6 0.1 0.73 10.4 0.0 2.1 2 0 0 2 2 2 0 PQQ-like domain FAM76 PF16046.5 ETO14841.1 - 0.15 11.4 5.5 0.23 10.8 5.5 1.2 1 0 0 1 1 1 0 FAM76 protein Nup88 PF10168.9 ETO14842.1 - 0.48 8.2 17.6 0.52 8.0 17.6 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF4448 PF14610.6 ETO14842.1 - 1.6 8.5 8.0 1.7 8.4 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF262 PF03235.14 ETO14842.1 - 1.8 8.7 12.4 2 8.6 12.4 1.0 1 0 0 1 1 1 0 Protein of unknown function DUF262 RNA_pol_Rpc4 PF05132.14 ETO14842.1 - 3.5 8.0 13.4 4 7.8 13.4 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 RPN2_C PF18004.1 ETO14842.1 - 4.4 7.2 25.3 5.1 7.0 25.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain TP53IP5 PF15331.6 ETO14842.1 - 4.6 7.3 16.6 5.3 7.1 16.6 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF3807 PF12720.7 ETO14842.1 - 6.4 7.0 18.8 7.1 6.9 18.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) PPL5 PF18168.1 ETO14842.1 - 7.2 5.8 13.6 7.4 5.8 13.6 1.0 1 0 0 1 1 1 0 Prim-pol family 5 AIF_C PF14721.6 ETO14842.1 - 7.8 6.9 12.6 8.8 6.7 12.6 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Presenilin PF01080.17 ETO14842.1 - 9.2 4.9 11.6 10 4.8 11.6 1.0 1 0 0 1 1 1 0 Presenilin zf-C3HC4_2 PF13923.6 ETO14843.1 - 1.2 9.0 7.9 5.2 7.0 4.8 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) eIF-5_eIF-2B PF01873.17 ETO14844.1 - 1.3e-16 60.5 5.2 1.4e-16 60.4 3.5 1.9 2 0 0 2 2 2 1 Domain found in IF2B/IF5 W2 PF02020.18 ETO14844.1 - 2.2e-09 37.3 0.7 2.2e-09 37.3 0.7 2.6 3 0 0 3 3 3 1 eIF4-gamma/eIF5/eIF2-epsilon Stanniocalcin PF03298.13 ETO14845.1 - 0.019 14.3 2.1 0.025 13.9 2.1 1.3 1 0 0 1 1 1 0 Stanniocalcin family FliT PF05400.13 ETO14845.1 - 0.11 13.3 0.1 0.11 13.3 0.1 2.7 2 1 0 2 2 2 0 Flagellar protein FliT SbsC_C PF18058.1 ETO14845.1 - 0.84 9.9 11.3 1.3 9.3 11.3 1.3 1 0 0 1 1 1 0 SbsC C-terminal domain EP400_N PF15790.5 ETO14845.1 - 0.86 8.4 4.6 1 8.1 4.6 1.2 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal DUF1943 PF09172.11 ETO14845.1 - 5.4 6.2 8.6 6.6 5.9 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) TMEM132D_C PF15706.5 ETO14846.1 - 0.22 11.3 0.8 0.66 9.8 0.8 1.8 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term HAUS6_N PF14661.6 ETO14847.1 - 0.015 14.9 0.2 0.018 14.7 0.2 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF2745 PF10922.8 ETO14849.1 - 0.041 14.2 0.2 0.11 12.8 0.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2745) DUF1322 PF07032.11 ETO14849.1 - 0.066 13.7 0.9 0.066 13.7 0.9 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1322) Kelch_6 PF13964.6 ETO14850.1 - 0.0008 19.6 0.9 0.0096 16.2 0.0 2.8 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO14850.1 - 0.049 13.2 0.6 0.38 10.4 0.1 2.7 3 0 0 3 3 3 0 Kelch motif Glucokinase PF02685.16 ETO14850.1 - 0.051 12.6 0.0 1.5 7.8 0.0 2.0 2 0 0 2 2 2 0 Glucokinase GlcNAc PF11397.8 ETO14851.1 - 3.5e-32 112.2 0.0 4e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) Glyco_trans_2_3 PF13632.6 ETO14851.1 - 0.0035 17.3 0.0 0.0035 17.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family group 2 Kelch_5 PF13854.6 ETO14853.1 - 5.2e-05 23.1 0.2 0.0075 16.2 0.2 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO14853.1 - 0.0058 16.2 3.8 0.15 11.7 0.1 4.3 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO14853.1 - 0.013 15.5 0.1 0.013 15.5 0.1 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO14853.1 - 0.86 9.7 4.7 5.6 7.1 0.4 3.7 4 0 0 4 4 4 0 Kelch motif VWA PF00092.28 ETO14854.1 - 7.4e-12 45.9 0.1 1.6e-11 44.8 0.1 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO14854.1 - 1.8e-09 38.2 0.1 4.9e-09 36.8 0.1 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain NOG1 PF06858.14 ETO14854.1 - 0.016 15.0 0.0 6.2 6.7 0.1 2.6 2 0 0 2 2 2 0 Nucleolar GTP-binding protein 1 (NOG1) VWA_3 PF13768.6 ETO14854.1 - 0.037 14.0 0.0 0.073 13.0 0.0 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain tRNA_NucTransf2 PF09249.11 ETO14854.1 - 0.042 14.1 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain NUC173 PF08161.12 ETO14855.1 - 2.9e-14 53.2 3.0 2.3e-11 43.8 0.0 3.3 4 0 0 4 4 4 2 NUC173 domain Borrelia_P83 PF05262.11 ETO14856.1 - 4.2 5.7 20.9 5.4 5.4 20.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Golgin_A5 PF09787.9 ETO14857.1 - 0.026 14.0 10.1 0.032 13.7 10.1 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 DASH_Duo1 PF08651.10 ETO14857.1 - 0.031 14.0 2.8 0.031 14.0 2.8 1.8 2 0 0 2 2 2 0 DASH complex subunit Duo1 DUF421 PF04239.12 ETO14857.1 - 0.033 14.0 1.2 0.033 14.0 1.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF421) PRKG1_interact PF15898.5 ETO14857.1 - 0.043 14.7 8.5 0.053 14.4 8.5 1.2 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain FapA PF03961.13 ETO14857.1 - 0.73 8.4 9.6 0.82 8.2 9.6 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A IFP_35_N PF07334.13 ETO14857.1 - 4.8 7.3 13.3 9.9 6.3 0.6 2.4 2 2 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus HSP70 PF00012.20 ETO14858.1 - 6.4e-13 47.8 1.6 3.3e-12 45.4 0.0 2.6 2 1 0 3 3 3 1 Hsp70 protein zf-TAZ PF02135.16 ETO14858.1 - 0.2 12.2 4.2 0.9 10.0 1.1 2.7 2 0 0 2 2 2 0 TAZ zinc finger YL1 PF05764.13 ETO14859.1 - 7.6e-05 22.9 14.3 0.00011 22.5 14.3 1.1 1 0 0 1 1 1 1 YL1 nuclear protein PHD PF00628.29 ETO14859.1 - 0.0056 16.5 17.7 0.01 15.7 17.7 1.5 1 0 0 1 1 1 1 PHD-finger LAP1C PF05609.12 ETO14859.1 - 0.87 8.6 11.0 1.1 8.3 11.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) NST1 PF13945.6 ETO14859.1 - 3.9 7.5 15.6 3.4 7.7 13.4 1.9 2 0 0 2 2 2 0 Salt tolerance down-regulator ALMT PF11744.8 ETO14859.1 - 5.8 5.6 6.0 8.3 5.1 6.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 ETO14859.1 - 7.5 4.7 13.9 9.6 4.4 13.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO14859.1 - 9.9 5.3 9.6 15 4.6 9.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Exo_endo_phos PF03372.23 ETO14860.1 - 7.1e-13 48.6 0.0 1.2e-12 47.9 0.0 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ETO14860.1 - 5.2e-05 23.1 1.1 0.00011 22.0 1.1 1.6 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase EF-hand_7 PF13499.6 ETO14862.1 - 0.0087 16.5 0.1 0.017 15.6 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO14863.1 - 0.0025 18.1 0.1 0.0034 17.7 0.1 1.4 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_1 PF00036.32 ETO14863.1 - 0.0032 16.9 0.0 0.0063 16.0 0.0 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO14863.1 - 0.011 15.6 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 0 EF-hand domain EF-hand_5 PF13202.6 ETO14863.1 - 0.034 13.6 0.0 0.059 12.9 0.0 1.3 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 ETO14863.1 - 0.09 13.2 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 EF-hand domain pair ADH_zinc_N PF00107.26 ETO14865.1 - 2.1e-08 34.2 0.1 5.3e-08 32.9 0.1 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO14865.1 - 2e-05 25.7 0.0 4.5e-05 24.5 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ETO14866.1 - 1.1e-06 28.5 0.0 6.9e-06 25.9 0.0 2.1 1 1 0 1 1 1 1 N-terminal domain of oxidoreductase RIBIOP_C PF04950.12 ETO14867.1 - 2.1e-43 148.8 2.3 9e-43 146.8 0.0 2.8 2 1 0 2 2 2 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ETO14867.1 - 7.1e-18 64.5 0.0 3.1e-17 62.4 0.0 2.2 1 0 0 1 1 1 1 AARP2CN (NUC121) domain RIBIOP_C PF04950.12 ETO14868.1 - 3e-26 92.5 0.1 3.4e-26 92.4 0.1 1.0 1 0 0 1 1 1 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal UDPG_MGDP_dh_N PF03721.14 ETO14870.1 - 1.4e-56 191.1 0.0 2.1e-56 190.5 0.0 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ETO14870.1 - 5.7e-33 113.5 0.5 9.1e-32 109.6 0.2 2.6 3 0 0 3 3 3 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain UDPG_MGDP_dh PF00984.19 ETO14870.1 - 3.9e-31 107.1 0.0 9.5e-31 105.9 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain SPA PF08616.10 ETO14871.1 - 1.8e-06 27.9 0.0 5.6e-06 26.3 0.0 1.9 1 0 0 1 1 1 1 Stabilization of polarity axis Tim54 PF11711.8 ETO14871.1 - 0.0023 16.8 1.7 0.0055 15.6 1.7 1.6 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 RRN3 PF05327.11 ETO14871.1 - 0.0048 15.5 0.6 0.0048 15.5 0.6 1.5 2 0 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 UPF1_Zn_bind PF09416.10 ETO14871.1 - 0.023 14.7 0.1 0.51 10.3 0.0 2.3 2 0 0 2 2 2 0 RNA helicase (UPF2 interacting domain) Cwf_Cwc_15 PF04889.12 ETO14871.1 - 0.18 11.5 20.4 0.41 10.3 20.4 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETO14871.1 - 0.45 8.8 16.5 0.022 13.1 11.3 1.4 2 0 0 2 2 2 0 CDC45-like protein Apt1 PF10351.9 ETO14871.1 - 0.63 8.8 19.7 0.021 13.7 3.6 2.4 2 1 0 2 2 2 0 Golgi-body localisation protein domain Vfa1 PF08432.10 ETO14871.1 - 6.5 7.0 19.0 21 5.4 19.0 1.9 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 eIF-3c_N PF05470.12 ETO14871.1 - 8.5 4.5 13.4 14 3.9 13.4 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Nop14 PF04147.12 ETO14871.1 - 9.2 4.3 22.0 17 3.4 22.0 1.3 1 0 0 1 1 1 0 Nop14-like family FixQ PF05545.11 ETO14873.1 - 0.025 14.5 0.4 0.14 12.2 0.1 2.3 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ CCDC53 PF10152.9 ETO14874.1 - 2.4e-10 41.1 4.9 6.8e-07 29.8 0.7 2.3 2 0 0 2 2 2 2 Subunit CCDC53 of WASH complex DUF5333 PF17267.2 ETO14874.1 - 0.018 15.2 0.0 0.035 14.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5333) ALIX_LYPXL_bnd PF13949.6 ETO14874.1 - 0.066 12.5 0.0 0.087 12.1 0.0 1.1 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Cation_ATPase_N PF00690.26 ETO14875.1 - 7.7e-15 54.3 2.0 1.4e-12 47.1 0.8 2.9 2 1 0 2 2 2 1 Cation transporter/ATPase, N-terminus LPG_synthase_TM PF03706.13 ETO14875.1 - 0.0089 15.6 0.0 0.011 15.3 0.0 1.0 1 0 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region UCH PF00443.29 ETO14876.1 - 6.5e-18 65.2 0.2 1.1e-17 64.4 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PPO1_DWL PF12142.8 ETO14877.1 - 0.14 11.9 0.9 0.64 9.8 0.0 2.3 2 1 0 2 2 2 0 Polyphenol oxidase middle domain Ion_trans_2 PF07885.16 ETO14878.1 - 2e-15 56.5 24.9 9.3e-10 38.3 2.2 3.8 4 0 0 4 4 4 3 Ion channel LapA_dom PF06305.11 ETO14878.1 - 0.29 11.0 5.9 15 5.5 0.0 3.3 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain ER_lumen_recept PF00810.18 ETO14878.1 - 0.82 10.5 9.7 0.037 14.9 3.7 1.8 3 0 0 3 3 3 0 ER lumen protein retaining receptor DUF2981 PF11200.8 ETO14880.1 - 4.1 7.0 8.8 5.5 6.6 8.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) BACK PF07707.15 ETO14881.1 - 7.5e-08 32.4 0.1 4.7e-05 23.4 0.1 2.7 2 0 0 2 2 2 2 BTB And C-terminal Kelch CAP_GLY PF01302.25 ETO14882.1 - 2.6e-33 113.8 2.0 2.3e-17 62.8 0.1 2.3 2 0 0 2 2 2 2 CAP-Gly domain TetR_C_12 PF16914.5 ETO14882.1 - 0.19 11.9 0.0 0.41 10.8 0.0 1.5 1 0 0 1 1 1 0 Bacterial transcriptional repressor C-terminal MAPEG PF01124.18 ETO14883.1 - 1.6 8.6 4.2 16 5.4 0.3 2.1 1 1 0 2 2 2 0 MAPEG family NRDE-2 PF08424.10 ETO14884.1 - 5.8e-24 84.8 2.9 5.8e-24 84.8 2.9 2.4 2 1 0 2 2 2 1 NRDE-2, necessary for RNA interference TPR_2 PF07719.17 ETO14884.1 - 0.24 11.6 3.5 0.19 11.9 0.7 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO14884.1 - 0.87 10.1 10.7 0.71 10.4 0.1 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat GCR1_C PF12550.8 ETO14887.1 - 0.075 13.4 4.2 0.11 12.9 4.1 1.4 1 1 0 1 1 1 0 Transcriptional activator of glycolytic enzymes QueC PF06508.13 ETO14887.1 - 0.17 11.3 1.0 0.21 11.1 1.0 1.0 1 0 0 1 1 1 0 Queuosine biosynthesis protein QueC Microcin PF03526.13 ETO14887.1 - 0.57 10.0 3.8 1.4 8.7 3.8 1.7 1 1 0 1 1 1 0 Colicin E1 (microcin) immunity protein NACHT PF05729.12 ETO14888.1 - 7.4e-11 42.2 0.0 1.8e-10 41.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO14888.1 - 0.00087 19.8 0.0 0.011 16.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO14888.1 - 0.0014 18.9 0.0 0.0056 17.0 0.0 2.1 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO14888.1 - 0.014 15.9 0.8 0.064 13.8 0.8 2.2 1 1 0 1 1 1 0 ABC transporter TniB PF05621.11 ETO14888.1 - 0.021 14.3 0.0 0.056 12.9 0.0 1.7 1 0 0 1 1 1 0 Bacterial TniB protein CUE PF02845.16 ETO14888.1 - 0.086 12.6 0.1 0.33 10.7 0.0 2.1 2 0 0 2 2 2 0 CUE domain RNA_helicase PF00910.22 ETO14888.1 - 0.1 13.0 4.8 0.26 11.7 0.0 3.5 3 1 0 3 3 3 0 RNA helicase BSMAP PF12280.8 ETO14888.1 - 1.1 9.4 4.5 1 9.5 1.1 2.7 3 0 0 3 3 3 0 Brain specific membrane anchored protein GPS PF01825.21 ETO14890.1 - 5.4e-08 33.2 8.6 1.7e-07 31.6 8.6 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Adhesin_P1_N PF18652.1 ETO14890.1 - 0.14 12.2 3.3 0.37 10.8 3.3 1.7 1 0 0 1 1 1 0 Adhesin P1 N-terminal domain WD40 PF00400.32 ETO14891.1 - 3e-47 157.6 22.9 3.6e-07 30.8 0.1 8.2 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14891.1 - 1e-14 54.6 6.7 0.002 18.4 0.0 6.7 5 3 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14891.1 - 6.1e-11 41.7 10.8 0.067 11.8 0.1 6.9 5 2 0 7 7 7 6 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO14891.1 - 4.7e-05 24.0 0.6 0.00028 21.5 0.6 2.5 1 0 0 1 1 1 1 TRAF-type zinc finger FAM76 PF16046.5 ETO14891.1 - 6.7e-05 22.4 14.0 0.00017 21.0 14.0 1.8 1 0 0 1 1 1 1 FAM76 protein MPS2 PF17060.5 ETO14891.1 - 0.0071 15.7 10.8 0.012 14.9 10.8 1.3 1 0 0 1 1 1 1 Monopolar spindle protein 2 zf-C3HC4_2 PF13923.6 ETO14891.1 - 2.3 8.1 5.4 3 7.8 2.1 3.0 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4407 PF14362.6 ETO14891.1 - 4.7 6.5 10.6 7.5 5.8 10.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Metallophos PF00149.28 ETO14892.1 - 2.1e-10 41.4 0.7 2.9e-10 41.0 0.7 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO14892.1 - 0.00011 22.5 0.0 0.0013 19.0 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Kinesin PF00225.23 ETO14893.1 - 1.5e-19 70.1 0.0 1.5e-19 70.1 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO14893.1 - 4.5e-12 46.1 0.0 7.3e-12 45.5 0.0 1.3 1 0 0 1 1 1 1 Microtubule binding YMF19 PF02326.15 ETO14893.1 - 4 8.3 8.9 9 7.2 3.6 2.4 2 0 0 2 2 2 0 Plant ATP synthase F0 SHE3 PF17078.5 ETO14894.1 - 0.0002 21.2 21.3 0.0002 21.2 21.3 3.5 2 1 0 3 3 3 1 SWI5-dependent HO expression protein 3 DUF4250 PF14056.6 ETO14894.1 - 0.25 11.3 1.6 13 5.9 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) Peptidase_M50B PF13398.6 ETO14895.1 - 0.078 12.6 1.0 0.096 12.3 1.0 1.1 1 0 0 1 1 1 0 Peptidase M50B-like GWT1 PF06423.12 ETO14895.1 - 0.17 12.0 7.0 0.59 10.2 7.0 1.9 1 1 0 1 1 1 0 GWT1 Peptidase_S55 PF05580.12 ETO14895.1 - 1.7 8.6 6.3 2.2 8.2 6.3 1.1 1 0 0 1 1 1 0 SpoIVB peptidase S55 Cnd1_N PF12922.7 ETO14895.1 - 7.7 6.3 12.2 1.5 8.7 2.7 2.2 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term PerC PF06069.11 ETO14897.1 - 0.13 12.6 0.1 0.38 11.0 0.0 1.8 2 0 0 2 2 2 0 PerC transcriptional activator Gly_rich PF12810.7 ETO14898.1 - 2.1e-13 50.7 23.1 3.5e-13 50.0 23.1 1.3 1 0 0 1 1 1 1 Glycine rich protein PTPRCAP PF15713.5 ETO14898.1 - 0.58 10.4 5.6 1.3 9.3 5.6 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Apolipoprotein PF01442.18 ETO14899.1 - 0.042 13.7 3.2 0.08 12.8 3.2 1.5 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain EspB PF05802.11 ETO14899.1 - 0.065 13.2 0.6 0.11 12.5 0.6 1.3 1 0 0 1 1 1 0 Enterobacterial EspB protein FlgN PF05130.12 ETO14899.1 - 0.68 10.4 12.7 2.8 8.4 0.3 2.7 1 1 2 3 3 3 0 FlgN protein FliT PF05400.13 ETO14899.1 - 0.87 10.4 6.8 2.1 9.2 1.4 2.6 1 1 1 2 2 2 0 Flagellar protein FliT ZnuA PF01297.17 ETO14899.1 - 0.91 8.9 2.9 15 4.9 0.3 2.5 1 1 1 2 2 2 0 Zinc-uptake complex component A periplasmic FAM184 PF15665.5 ETO14899.1 - 1.3 8.7 15.2 0.79 9.5 1.3 2.1 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B DUF1664 PF07889.12 ETO14899.1 - 2.1 8.4 11.1 6 6.9 1.3 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 ETO14899.1 - 2.5 7.6 5.5 3.5 7.1 5.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CAP_GLY PF01302.25 ETO14900.1 - 1.6e-27 95.3 9.3 4.8e-08 32.9 0.2 4.4 3 1 1 4 4 4 4 CAP-Gly domain WWE PF02825.20 ETO14901.1 - 1e-05 26.0 1.5 0.0007 20.1 0.2 2.3 2 0 0 2 2 2 2 WWE domain DUF2229 PF09989.9 ETO14901.1 - 0.013 15.2 1.4 0.016 14.9 1.4 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Pcc1 PF09341.10 ETO14903.1 - 1.2e-07 31.8 0.0 2.5e-07 30.7 0.0 1.6 2 0 0 2 2 2 1 Transcription factor Pcc1 DTHCT PF08070.11 ETO14903.1 - 0.0015 19.3 6.1 0.0019 18.9 6.1 1.1 1 0 0 1 1 1 1 DTHCT (NUC029) region DUF2207 PF09972.9 ETO14904.1 - 0.11 11.3 0.4 0.13 11.0 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TMEM72 PF16054.5 ETO14904.1 - 1.9 8.2 8.6 1.9 8.1 8.1 1.2 1 1 0 1 1 1 0 Transmembrane protein family 72 Tubulin PF00091.25 ETO14905.1 - 6.4e-06 26.5 0.1 8.8e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain CNOT1_HEAT_N PF16419.5 ETO14905.1 - 0.02 14.6 0.5 0.024 14.3 0.5 1.2 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat SecA_DEAD PF07517.14 ETO14908.1 - 1.5e-10 40.9 0.0 7.8e-10 38.5 0.0 2.3 1 1 0 1 1 1 1 SecA DEAD-like domain Menin PF05053.13 ETO14910.1 - 0.056 11.8 3.9 0.058 11.7 3.9 1.0 1 0 0 1 1 1 0 Menin RT_RNaseH_2 PF17919.1 ETO14912.1 - 3.8e-20 71.8 0.1 6.3e-20 71.1 0.1 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ETO14912.1 - 4.6e-15 55.7 0.3 7.6e-15 55.0 0.1 1.5 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 ETO14912.1 - 1.1e-09 38.5 0.0 2.4e-09 37.4 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Kelch_1 PF01344.25 ETO14913.1 - 0.00057 19.4 0.3 0.014 15.0 0.2 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO14913.1 - 0.001 19.3 0.3 0.0059 16.8 0.1 2.2 2 0 0 2 2 2 1 Kelch motif Terminase_3 PF04466.13 ETO14913.1 - 0.032 13.8 0.0 0.82 9.2 0.0 2.1 1 1 1 2 2 2 0 Phage terminase large subunit Kelch_2 PF07646.15 ETO14913.1 - 0.23 11.5 1.1 1.3 9.1 0.1 2.7 3 1 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO14915.1 - 0.059 14.3 2.9 63 4.7 0.0 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat PH_12 PF16457.5 ETO14916.1 - 1.7e-06 28.6 0.0 1.7e-06 28.6 0.0 2.9 2 1 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO14916.1 - 0.0011 19.1 0.0 0.0035 17.5 0.0 1.9 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Rbx_binding PF18113.1 ETO14917.1 - 0.013 15.2 0.0 0.025 14.4 0.0 1.3 1 0 0 1 1 1 0 Rubredoxin binding C-terminal domain GN3L_Grn1 PF08701.11 ETO14918.1 - 9.3e-17 60.9 20.8 9.3e-17 60.9 20.8 2.0 1 1 1 2 2 2 1 GNL3L/Grn1 putative GTPase RPOL_N PF14700.6 ETO14918.1 - 0.019 14.4 0.2 0.019 14.4 0.2 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal DUF3781 PF12636.7 ETO14918.1 - 0.024 14.5 3.2 0.15 12.0 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3781) XPG_I_2 PF12813.7 ETO14918.1 - 0.026 14.0 2.4 0.031 13.8 2.4 1.1 1 0 0 1 1 1 0 XPG domain containing XRN_M PF17846.1 ETO14918.1 - 0.15 10.9 5.3 0.18 10.7 5.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain UPF0688 PF15772.5 ETO14918.1 - 0.27 11.5 7.4 0.3 11.3 7.4 1.1 1 0 0 1 1 1 0 UPF0688 family ATP-synt_E PF05680.12 ETO14918.1 - 1.8 8.9 12.0 2.6 8.5 3.9 2.1 2 0 0 2 2 2 0 ATP synthase E chain WD40 PF00400.32 ETO14919.1 - 1.5e-34 117.4 11.7 8e-08 32.8 0.7 5.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO14919.1 - 5.4e-12 45.3 0.1 0.037 13.0 0.0 5.0 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO14919.1 - 2.3e-09 37.4 0.5 0.49 10.7 0.0 4.8 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO14919.1 - 0.0021 16.8 1.1 0.44 9.1 0.1 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO14919.1 - 0.011 15.6 0.0 0.85 9.5 0.0 2.9 2 2 1 3 3 3 0 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETO14919.1 - 0.027 13.2 0.6 2.8 6.6 0.2 2.9 2 1 1 3 3 3 0 Nup133 N terminal like WD40_like PF17005.5 ETO14919.1 - 0.099 11.9 0.1 0.35 10.1 0.0 1.9 1 1 0 2 2 2 0 WD40-like domain PD40 PF07676.12 ETO14919.1 - 0.11 12.5 0.1 1.2e+02 2.7 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF4072 PF13284.6 ETO14919.1 - 0.17 12.4 0.0 14 6.2 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4072) Kelch_4 PF13418.6 ETO14920.1 - 7.2e-05 22.7 0.1 0.00012 22.0 0.1 1.3 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO14920.1 - 0.022 14.4 0.4 0.039 13.6 0.4 1.4 1 0 0 1 1 1 0 Kelch motif ATG11 PF10377.9 ETO14920.1 - 0.092 12.8 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 Kelch_5 PF13854.6 ETO14920.1 - 0.097 12.7 0.8 0.19 11.7 0.8 1.5 1 0 0 1 1 1 0 Kelch motif NACHT PF05729.12 ETO14921.1 - 6.3e-08 32.7 0.1 1.3e-07 31.6 0.0 1.5 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 ETO14921.1 - 0.00083 19.8 0.0 0.0019 18.6 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain ATPase PF06745.13 ETO14921.1 - 0.002 17.5 0.0 0.0035 16.7 0.0 1.3 1 0 0 1 1 1 1 KaiC NB-ARC PF00931.22 ETO14921.1 - 0.0021 17.3 0.7 0.0033 16.6 0.0 1.7 2 1 0 2 2 2 1 NB-ARC domain DAP3 PF10236.9 ETO14921.1 - 0.034 13.3 0.0 0.055 12.6 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 RNA_helicase PF00910.22 ETO14921.1 - 0.05 14.0 0.2 0.44 11.0 0.0 2.5 2 1 1 3 3 3 0 RNA helicase AAA_22 PF13401.6 ETO14921.1 - 0.058 13.7 0.0 0.19 12.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_30 PF13604.6 ETO14921.1 - 0.081 12.6 0.2 0.27 10.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain MRP-L46 PF11788.8 ETO14921.1 - 0.46 11.2 4.7 0.11 13.2 1.6 1.6 2 1 0 2 2 2 0 39S mitochondrial ribosomal protein L46 HEAT PF02985.22 ETO14922.1 - 9.3e-12 44.1 11.1 1.9 8.9 0.0 11.1 12 0 0 12 12 11 3 HEAT repeat HEAT_2 PF13646.6 ETO14922.1 - 1.8e-09 37.9 0.0 0.0039 17.6 0.0 6.4 5 1 2 7 7 7 3 HEAT repeats Cnd1 PF12717.7 ETO14922.1 - 6.6e-09 36.0 16.2 0.0041 17.2 1.9 6.0 3 2 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 NACHT PF05729.12 ETO14922.1 - 3e-07 30.5 0.0 1.5e-06 28.2 0.0 2.3 1 0 0 1 1 1 1 NACHT domain HEAT_EZ PF13513.6 ETO14922.1 - 0.00022 21.6 0.2 3.3 8.3 0.0 6.1 7 0 0 7 7 6 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO14922.1 - 0.017 15.7 8.0 12 6.6 0.0 5.7 4 2 2 6 6 5 0 Vacuolar 14 Fab1-binding region Ank_2 PF12796.7 ETO14922.1 - 0.062 13.9 0.1 0.41 11.3 0.1 2.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) NLRC4_HD2 PF17776.1 ETO14922.1 - 0.065 13.8 5.2 1.7 9.2 0.0 4.6 3 1 0 4 4 4 0 NLRC4 helical domain HD2 Ank_3 PF13606.6 ETO14922.1 - 0.081 13.5 0.8 0.76 10.5 0.0 3.2 3 0 0 3 3 2 0 Ankyrin repeat Stork_head PF10264.9 ETO14922.1 - 0.09 13.0 0.1 0.76 10.0 0.1 2.7 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain N_Asn_amidohyd PF14736.6 ETO14922.1 - 0.1 11.7 3.1 3.2 6.8 0.0 3.2 3 1 1 4 4 4 0 Protein N-terminal asparagine amidohydrolase Ank_5 PF13857.6 ETO14922.1 - 0.12 12.8 0.0 0.5 10.8 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeats (many copies) TraC PF07820.12 ETO14922.1 - 0.2 12.0 0.1 60 4.1 0.0 3.2 2 1 1 3 3 3 0 TraC-like protein WD40 PF00400.32 ETO14923.1 - 1.1e-45 152.7 18.2 5.3e-08 33.4 0.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14923.1 - 6.3e-20 71.3 2.4 0.0041 17.4 0.1 6.2 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO14923.1 - 1.6e-07 31.1 0.1 6.2 6.9 0.0 5.7 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO14923.1 - 0.00028 19.5 0.0 0.47 8.9 0.0 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO14923.1 - 0.00029 20.2 0.6 0.35 10.2 0.3 3.2 2 1 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 ETO14923.1 - 0.00036 19.3 3.6 4.7 5.7 0.6 4.0 2 1 0 3 3 3 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO14923.1 - 0.0008 18.8 1.8 0.26 10.6 0.0 4.1 1 1 5 6 6 6 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO14923.1 - 0.04 14.0 0.3 55 3.9 0.0 3.7 3 1 0 4 4 4 0 Family of unknown function (DUF5570) Gmad1 PF10647.9 ETO14923.1 - 0.27 11.0 0.1 0.86 9.3 0.0 1.9 3 0 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.9 ETO14923.1 - 0.33 10.7 2.5 42 3.9 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Kelch_2 PF07646.15 ETO14924.1 - 7.3e-08 32.1 0.3 7.3e-05 22.6 0.1 3.8 3 1 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO14924.1 - 8.5e-08 32.2 2.2 0.00036 20.7 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO14924.1 - 1.1e-05 25.3 0.2 0.00022 21.2 0.2 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO14924.1 - 2.7e-05 23.6 0.9 0.0023 17.5 0.3 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO14924.1 - 0.00017 21.5 1.5 0.01 15.8 0.9 3.0 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO14924.1 - 0.0007 19.8 0.1 0.013 15.7 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain TMEM95 PF15203.6 ETO14925.1 - 0.012 15.3 1.7 0.014 15.1 1.7 1.3 1 0 0 1 1 1 0 TMEM95 family GIT_CC PF16559.5 ETO14925.1 - 0.024 14.5 9.1 0.024 14.5 9.1 1.8 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 ETO14925.1 - 0.025 14.4 8.7 0.025 14.4 8.7 2.4 1 1 1 2 2 2 0 Septum formation initiator CHD5 PF04420.14 ETO14925.1 - 0.036 13.9 8.9 0.052 13.4 8.9 1.4 1 0 0 1 1 1 0 CHD5-like protein Atg14 PF10186.9 ETO14925.1 - 0.085 11.9 15.5 0.097 11.7 15.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMPIT PF07851.13 ETO14925.1 - 0.11 11.8 11.7 0.12 11.5 11.7 1.1 1 0 0 1 1 1 0 TMPIT-like protein HEPN_Toprim_N PF18871.1 ETO14925.1 - 0.13 12.2 2.9 0.16 11.8 2.9 1.1 1 0 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 DUF3251 PF11622.8 ETO14925.1 - 0.15 11.7 2.1 0.21 11.2 2.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3251) Mgr1 PF08602.10 ETO14925.1 - 0.33 9.7 7.8 0.39 9.5 7.8 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit AAA_11 PF13086.6 ETO14925.1 - 0.89 9.3 10.2 1 9.1 10.2 1.1 1 0 0 1 1 1 0 AAA domain DUF4795 PF16043.5 ETO14925.1 - 1.5 8.4 19.5 6.3 6.3 4.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) MDM10 PF12519.8 ETO14925.1 - 5.2 5.8 8.8 5.3 5.8 8.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Phage_int_SAM_4 PF13495.6 ETO14926.1 - 0.038 14.5 0.0 0.072 13.6 0.0 1.5 1 0 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain WD40 PF00400.32 ETO14927.1 - 6.8e-22 77.4 11.6 6.3e-07 30.0 1.7 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO14927.1 - 5.8e-06 25.2 3.9 0.004 15.9 0.5 2.8 2 1 0 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14927.1 - 1e-05 25.7 0.0 0.089 13.1 0.0 2.7 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain ArlS_N PF18719.1 ETO14927.1 - 0.11 12.7 0.4 0.48 10.6 0.1 2.2 2 1 0 2 2 2 0 ArlS sensor domain zf-MYND PF01753.18 ETO14928.1 - 1.5e-08 34.6 13.1 3.3e-08 33.5 13.1 1.6 1 0 0 1 1 1 1 MYND finger zf-Mss51 PF13824.6 ETO14928.1 - 0.27 11.3 4.3 0.73 10.0 4.3 1.7 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 Septin PF00735.18 ETO14929.1 - 6.2e-05 22.4 0.0 0.00013 21.3 0.0 1.6 1 0 0 1 1 1 1 Septin MMR_HSR1 PF01926.23 ETO14929.1 - 0.00012 22.1 0.0 0.00036 20.6 0.0 1.8 1 1 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO14929.1 - 0.0004 20.0 0.0 0.00099 18.7 0.0 1.6 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_23 PF13476.6 ETO14929.1 - 0.0017 18.9 3.8 0.0045 17.5 3.8 1.7 1 1 0 1 1 1 1 AAA domain AIG1 PF04548.16 ETO14929.1 - 0.0021 17.4 0.3 0.02 14.2 0.0 2.3 3 0 0 3 3 3 1 AIG1 family Fer4_14 PF13394.6 ETO14929.1 - 0.0042 17.2 0.2 0.02 15.0 0.0 2.1 2 1 0 2 2 2 1 4Fe-4S single cluster domain ABC_tran PF00005.27 ETO14929.1 - 0.011 16.3 0.0 0.067 13.7 0.0 2.1 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 ETO14929.1 - 0.014 15.3 0.3 0.17 11.8 0.3 2.5 1 1 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ETO14929.1 - 0.018 15.3 0.1 0.056 13.7 0.1 2.0 1 1 0 1 1 1 0 AAA domain Gtr1_RagA PF04670.12 ETO14929.1 - 0.02 14.2 0.0 0.89 8.9 0.0 2.6 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ETO14929.1 - 0.024 15.0 1.0 0.066 13.6 0.0 2.2 2 2 0 2 2 2 0 AAA ATPase domain Drf_FH3 PF06367.16 ETO14929.1 - 0.026 14.2 0.2 0.051 13.2 0.2 1.4 1 0 0 1 1 1 0 Diaphanous FH3 Domain PduV-EutP PF10662.9 ETO14929.1 - 0.028 14.2 0.0 0.12 12.1 0.0 2.0 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_21 PF13304.6 ETO14929.1 - 0.063 13.1 0.0 0.14 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETO14929.1 - 0.064 13.0 0.1 0.13 12.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ETO14929.1 - 0.11 12.5 0.0 0.25 11.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ETO14929.1 - 0.12 12.1 0.3 0.36 10.5 0.3 2.0 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 ETO14930.1 - 2.8e-11 43.8 3.3 1.3e-05 25.9 0.7 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO14930.1 - 0.0042 15.8 0.3 0.93 8.1 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO14930.1 - 0.016 15.5 0.0 2 8.8 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RabGAP-TBC PF00566.18 ETO14931.1 - 7.5e-10 38.8 1.5 7.5e-10 38.8 1.5 3.9 4 0 0 4 4 4 1 Rab-GTPase-TBC domain TFIIA PF03153.13 ETO14931.1 - 0.00041 20.5 35.0 0.00041 20.5 35.0 2.9 1 1 2 3 3 3 1 Transcription factor IIA, alpha/beta subunit DUF3439 PF11921.8 ETO14931.1 - 6.4 6.8 26.7 0.38 10.7 16.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) RabGAP-TBC PF00566.18 ETO14932.1 - 1.5e-14 54.1 3.1 1.5e-14 54.1 3.1 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.29 ETO14932.1 - 0.0006 20.3 0.3 0.0012 19.3 0.3 1.6 1 0 0 1 1 1 1 PH domain vATP-synt_E PF01991.18 ETO14933.1 - 0.73 9.2 12.1 1.1 8.6 12.1 1.3 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Fis1_TPR_C PF14853.6 ETO14935.1 - 0.0014 18.7 0.4 0.0037 17.3 0.4 1.7 1 0 0 1 1 1 1 Fis1 C-terminal tetratricopeptide repeat TPR_8 PF13181.6 ETO14935.1 - 0.0039 17.3 2.9 0.0066 16.6 0.9 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2428 PF10350.9 ETO14935.1 - 0.0064 15.8 0.5 0.015 14.6 0.5 1.6 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) TPR_2 PF07719.17 ETO14935.1 - 0.0076 16.3 4.6 0.018 15.1 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14935.1 - 0.0084 15.9 1.0 0.0084 15.9 1.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO14935.1 - 0.02 15.2 0.1 0.076 13.3 0.1 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO14935.1 - 0.041 14.5 0.1 0.15 12.8 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14935.1 - 0.068 13.4 1.1 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 UCH PF00443.29 ETO14937.1 - 2e-18 66.8 1.9 3.3e-18 66.1 0.3 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO14937.1 - 1.3e-06 28.3 1.5 3.5e-06 26.8 0.0 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4576 PF15144.6 ETO14937.1 - 0.083 12.8 0.0 0.37 10.7 0.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) DUF728 PF05304.12 ETO14937.1 - 1.3 8.8 5.3 0.64 9.9 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF728) NTP_transf_2 PF01909.23 ETO14938.1 - 3.2e-07 30.6 0.0 8.3e-07 29.2 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO14938.1 - 0.00031 20.8 0.0 0.00077 19.5 0.0 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase DUF294 PF03445.13 ETO14938.1 - 0.066 13.0 0.0 0.12 12.2 0.0 1.4 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 RlaP PF10127.9 ETO14938.1 - 0.12 11.9 0.0 0.22 11.1 0.0 1.4 1 0 0 1 1 1 0 RNA repair pathway DNA polymerase beta family NACHT PF05729.12 ETO14940.1 - 1.3e-07 31.7 0.0 2.4e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 NACHT domain DRY_EERY PF09750.9 ETO14940.1 - 0.0036 17.6 1.9 0.0057 16.9 1.9 1.3 1 0 0 1 1 1 1 Alternative splicing regulator NB-ARC PF00931.22 ETO14940.1 - 0.0086 15.3 1.4 0.012 14.8 0.0 1.8 2 1 1 3 3 3 1 NB-ARC domain AAA_16 PF13191.6 ETO14940.1 - 0.019 15.3 0.1 0.051 14.0 0.0 1.8 1 1 1 2 2 2 0 AAA ATPase domain ThiC-associated PF13667.6 ETO14940.1 - 0.054 13.3 0.2 0.15 11.9 0.2 1.7 1 0 0 1 1 1 0 ThiC-associated domain AAA_22 PF13401.6 ETO14940.1 - 0.075 13.3 0.0 0.23 11.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain RecG_N PF17190.4 ETO14941.1 - 0.053 14.3 0.2 0.22 12.3 0.2 2.1 1 0 0 1 1 1 0 RecG N-terminal helical domain RasGEF_N PF00618.20 ETO14941.1 - 0.16 12.2 0.2 0.16 12.2 0.2 4.1 2 1 0 2 2 2 0 RasGEF N-terminal motif DUF2207 PF09972.9 ETO14942.1 - 0.00036 19.5 0.1 0.00048 19.0 0.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) SLC12 PF03522.15 ETO14942.1 - 0.0038 16.3 2.3 0.0045 16.1 2.3 1.1 1 0 0 1 1 1 1 Solute carrier family 12 CDC45 PF02724.14 ETO14942.1 - 0.035 12.4 12.9 0.042 12.2 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein FAM60A PF15396.6 ETO14942.1 - 0.11 12.5 4.8 0.15 12.0 4.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 ETO14942.1 - 2.5 6.8 18.2 3.7 6.2 18.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sin_N PF04801.13 ETO14942.1 - 9.1 5.4 16.0 12 5.0 16.0 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region DUF3450 PF11932.8 ETO14943.1 - 0.44 9.8 24.4 0.019 14.3 3.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DUF3800 PF12686.7 ETO14943.1 - 0.65 10.6 3.2 2.4 8.8 3.3 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) Cep57_CLD_2 PF14197.6 ETO14943.1 - 1.4 9.0 29.0 0.93 9.6 11.0 4.5 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 EMP24_GP25L PF01105.24 ETO14943.1 - 2.3 8.1 12.2 0.93 9.4 1.9 2.7 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD Tropomyosin_1 PF12718.7 ETO14943.1 - 5 7.3 39.8 1 9.5 22.0 3.0 2 1 0 2 2 2 0 Tropomyosin like ATG16 PF08614.11 ETO14943.1 - 6.8 6.9 35.1 0.92 9.7 20.1 2.8 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) WBP-1 PF11669.8 ETO14944.1 - 0.51 11.0 8.1 3 8.5 0.2 4.5 4 1 1 5 5 5 0 WW domain-binding protein 1 Peptidase_C12 PF01088.21 ETO14945.1 - 4.6e-39 134.4 0.0 6.9e-39 133.8 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 Eno-Rase_FAD_bd PF07055.12 ETO14946.1 - 0.095 13.1 0.5 0.81 10.2 0.5 2.7 1 0 0 1 1 1 0 Enoyl reductase FAD binding domain Mac PF12464.8 ETO14946.1 - 0.18 12.1 1.0 2 8.7 0.1 3.0 2 0 0 2 2 2 0 Maltose acetyltransferase RPAP1_N PF08621.10 ETO14946.1 - 0.96 9.3 7.6 0.7 9.7 1.0 3.4 3 0 0 3 3 3 0 RPAP1-like, N-terminal Enkurin PF13864.6 ETO14946.1 - 4.2 7.9 15.1 0.78 10.2 0.5 3.9 2 1 1 3 3 3 0 Calmodulin-binding RRM_1 PF00076.22 ETO14947.1 - 7e-13 48.2 0.0 2e-12 46.7 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ETO14947.1 - 8.4e-06 25.9 0.0 2.1e-05 24.6 0.0 1.6 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RNA_bind PF08675.11 ETO14947.1 - 0.006 16.6 0.0 0.023 14.7 0.0 2.0 1 0 0 1 1 1 1 RNA binding domain TMEM51 PF15345.6 ETO14948.1 - 0.00092 19.1 0.2 0.00092 19.1 0.2 3.3 2 1 1 3 3 3 1 Transmembrane protein 51 TMEM154 PF15102.6 ETO14948.1 - 0.02 14.8 0.1 0.02 14.8 0.1 3.6 3 1 1 4 4 4 0 TMEM154 protein family MAP17 PF15807.5 ETO14948.1 - 0.039 14.2 0.2 0.039 14.2 0.2 3.8 4 0 0 4 4 4 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CbtA PF09490.10 ETO14948.1 - 0.053 13.3 0.2 0.053 13.3 0.2 2.7 3 1 1 4 4 4 0 Probable cobalt transporter subunit (CbtA) DUF948 PF06103.11 ETO14948.1 - 0.081 13.2 5.7 0.058 13.7 3.0 2.2 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Syndecan PF01034.20 ETO14948.1 - 0.26 11.2 2.2 2.3 8.2 0.1 2.7 2 0 0 2 2 2 0 Syndecan domain HemY_N PF07219.13 ETO14948.1 - 0.54 10.5 2.3 2 8.6 0.2 2.2 2 0 0 2 2 2 0 HemY protein N-terminus OAD_gamma PF04277.13 ETO14948.1 - 3.3 8.3 9.2 14 6.4 1.0 3.7 3 1 1 4 4 4 0 Oxaloacetate decarboxylase, gamma chain Methyltransf_10 PF05971.12 ETO14949.1 - 0.14 11.5 0.8 0.21 10.9 0.5 1.4 1 1 0 1 1 1 0 RNA methyltransferase TTL PF03133.15 ETO14951.1 - 2.4e-83 279.7 3.2 2.4e-83 279.7 3.2 1.7 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ETO14951.1 - 1.1e-08 34.7 0.2 0.00019 20.7 0.0 2.6 2 0 0 2 2 2 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ETO14951.1 - 0.0028 17.0 0.0 0.39 9.9 0.0 2.4 2 1 0 2 2 2 2 Sugar-transfer associated ATP-grasp SPC22 PF04573.12 ETO14951.1 - 0.041 13.4 0.1 0.095 12.2 0.1 1.6 1 0 0 1 1 1 0 Signal peptidase subunit RasGEF PF00617.19 ETO14953.1 - 1e-36 126.8 3.7 1e-36 126.8 3.7 1.7 2 0 0 2 2 2 1 RasGEF domain PUF PF00806.19 ETO14954.1 - 0.00084 18.9 0.0 0.04 13.6 0.0 2.7 2 0 0 2 2 2 2 Pumilio-family RNA binding repeat Kelch_2 PF07646.15 ETO14957.1 - 2e-06 27.5 4.1 8.1e-05 22.4 0.0 3.9 4 1 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO14957.1 - 8.7e-06 25.8 0.7 0.096 13.0 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO14957.1 - 7.9e-05 22.2 3.9 0.003 17.1 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO14957.1 - 0.0076 16.2 1.6 3.8 7.6 0.2 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO14957.1 - 0.014 15.4 0.4 0.19 11.7 0.0 3.0 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO14957.1 - 0.037 14.3 0.3 0.32 11.3 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Connexin PF00029.19 ETO14959.1 - 0.018 14.8 1.2 0.027 14.2 1.2 1.3 1 0 0 1 1 1 0 Connexin EST1 PF10374.9 ETO14959.1 - 0.045 14.4 1.4 0.058 14.0 1.4 1.1 1 0 0 1 1 1 0 Telomerase activating protein Est1 Peptidase_S49_N PF08496.10 ETO14959.1 - 0.086 12.9 4.4 0.12 12.5 4.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal O-ag_pol_Wzy PF14296.6 ETO14959.1 - 6.3 5.3 14.4 0.24 10.0 8.3 1.5 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy RPN7 PF10602.9 ETO14960.1 - 2.6e-13 50.1 0.0 4.7e-13 49.2 0.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ETO14960.1 - 1.6e-09 38.2 0.0 4.2e-09 36.9 0.0 1.7 1 0 0 1 1 1 1 PCI domain TPR_2 PF07719.17 ETO14960.1 - 0.00046 20.1 0.1 0.01 15.9 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14960.1 - 0.0032 17.2 0.0 0.018 14.9 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO14960.1 - 0.019 14.9 0.2 0.06 13.4 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14960.1 - 0.051 13.8 0.0 0.24 11.7 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_4 PF07721.14 ETO14960.1 - 0.081 13.6 0.5 0.23 12.2 0.5 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO14960.1 - 0.1 12.9 0.1 0.23 11.8 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO14960.1 - 0.17 11.8 0.1 0.43 10.5 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat AltA1 PF16541.5 ETO14961.1 - 0.051 14.5 0.8 0.077 13.9 0.8 1.3 1 0 0 1 1 1 0 Alternaria alternata allergen 1 Methyltransf_23 PF13489.6 ETO14961.1 - 0.082 12.7 0.1 0.54 10.1 0.0 2.0 1 1 0 2 2 2 0 Methyltransferase domain Med4 PF10018.9 ETO14962.1 - 1 9.0 26.6 0.02 14.6 17.6 2.3 1 1 1 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 U-box PF04564.15 ETO14963.1 - 3.6e-12 46.3 0.7 1.1e-11 44.7 0.1 2.3 2 0 0 2 2 2 1 U-box domain Phasin_2 PF09361.10 ETO14963.1 - 0.078 13.2 0.3 0.54 10.6 0.0 2.1 2 0 0 2 2 2 0 Phasin protein CGGC PF08821.11 ETO14963.1 - 2 8.6 6.9 0.35 11.1 1.1 2.4 1 1 0 2 2 2 0 CGGC domain FliJ PF02050.16 ETO14963.1 - 7 6.9 16.8 8.9 6.6 4.2 2.8 1 1 1 2 2 2 0 Flagellar FliJ protein DUF3231 PF11553.8 ETO14964.1 - 0.033 13.8 0.1 0.076 12.6 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3231) GHL15 PF14885.6 ETO14966.1 - 1.3e-08 35.2 1.7 2e-08 34.5 0.9 1.6 2 0 0 2 2 2 1 Hypothetical glycosyl hydrolase family 15 GHL15 PF14885.6 ETO14967.1 - 1.8e-11 44.5 0.0 2.2e-11 44.2 0.0 1.1 1 0 0 1 1 1 1 Hypothetical glycosyl hydrolase family 15 Kelch_5 PF13854.6 ETO14968.1 - 0.0083 16.1 0.1 0.34 11.0 0.0 3.0 3 0 0 3 3 3 1 Kelch motif N_Asn_amidohyd PF14736.6 ETO14968.1 - 0.012 14.7 0.1 1.4 8.0 0.0 2.4 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_6 PF13964.6 ETO14968.1 - 0.032 14.5 0.1 19 5.8 0.1 3.0 2 0 0 2 2 2 0 Kelch motif DUF5342 PF17277.2 ETO14968.1 - 0.11 12.8 2.8 0.15 12.4 0.1 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5342) RRM_1 PF00076.22 ETO14969.1 - 0.019 14.8 0.0 0.049 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LAP1C PF05609.12 ETO14969.1 - 1 8.4 18.3 1.3 8.0 18.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Otopetrin PF03189.13 ETO14969.1 - 3.6 6.3 5.6 33 3.1 5.6 2.0 1 1 0 1 1 1 0 Otopetrin Thioredoxin PF00085.20 ETO14970.1 - 1.3e-24 86.2 0.1 2.3e-24 85.4 0.1 1.4 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_6 PF13848.6 ETO14970.1 - 9e-08 32.2 0.3 1.6e-07 31.5 0.1 1.4 2 0 0 2 2 2 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ETO14970.1 - 9.8e-08 31.7 0.1 1.4e-07 31.2 0.1 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ETO14970.1 - 8.7e-07 29.4 0.4 1.5e-05 25.4 0.4 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain AhpC-TSA PF00578.21 ETO14970.1 - 1.7e-06 27.9 0.1 2.5e-06 27.4 0.1 1.3 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_7 PF13899.6 ETO14970.1 - 4.9e-05 23.4 0.0 0.00011 22.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Redoxin PF08534.10 ETO14970.1 - 0.00055 19.7 0.0 0.001 18.8 0.0 1.4 1 1 0 1 1 1 1 Redoxin Thioredoxin_3 PF13192.6 ETO14970.1 - 0.0011 18.9 0.0 0.002 18.1 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin domain Thioredoxin_8 PF13905.6 ETO14970.1 - 0.042 14.2 0.1 0.16 12.3 0.1 2.0 1 1 0 1 1 1 0 Thioredoxin-like DUF836 PF05768.14 ETO14970.1 - 0.094 13.1 0.1 0.16 12.4 0.1 1.4 1 1 0 1 1 1 0 Glutaredoxin-like domain (DUF836) F-box-like_2 PF13013.6 ETO14970.1 - 0.12 12.3 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 F-box-like domain Thioredoxin_6 PF13848.6 ETO14971.1 - 6.3e-23 81.6 2.4 6.5e-19 68.6 0.3 3.2 1 1 1 2 2 2 2 Thioredoxin-like domain Thioredoxin PF00085.20 ETO14971.1 - 3.1e-22 78.5 0.1 7.4e-21 74.1 0.0 2.3 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_2 PF13098.6 ETO14971.1 - 6.2e-05 23.4 0.1 0.0012 19.2 0.1 2.6 1 1 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ETO14971.1 - 0.011 15.9 0.4 0.067 13.4 0.0 2.4 2 1 1 3 3 3 0 Thioredoxin-like Thioredoxin_8 PF13905.6 ETO14971.1 - 0.083 13.2 2.1 1.1 9.6 0.1 3.0 2 2 0 2 2 2 0 Thioredoxin-like WD40 PF00400.32 ETO14972.1 - 2.4e-41 138.9 11.9 4.3e-07 30.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO14972.1 - 6.5e-09 36.0 3.2 0.15 12.4 0.0 5.1 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain HARP PF07443.13 ETO14972.1 - 0.0042 16.7 1.0 0.29 10.8 0.0 3.3 3 0 0 3 3 3 1 HepA-related protein (HARP) zf-TRAF PF02176.18 ETO14973.1 - 6.6e-06 26.7 3.1 6.6e-06 26.7 3.1 3.5 2 1 2 4 4 4 1 TRAF-type zinc finger zf-RING_2 PF13639.6 ETO14973.1 - 0.048 14.0 3.1 0.048 14.0 3.1 3.4 3 1 1 4 4 4 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO14973.1 - 0.79 9.6 8.6 2.4 8.1 5.8 3.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF4771 PF15995.5 ETO14973.1 - 2.2 8.5 7.8 0.38 11.0 3.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4771) CAP_GLY PF01302.25 ETO14976.1 - 2.7e-10 40.1 0.1 8.1e-10 38.6 0.0 1.9 2 0 0 2 2 2 1 CAP-Gly domain Imm40 PF15569.6 ETO14976.1 - 0.0094 16.0 0.3 0.19 11.9 0.1 2.2 2 0 0 2 2 2 1 Immunity protein 40 DUF5623 PF18536.1 ETO14976.1 - 0.03 14.6 0.1 0.2 12.0 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5623) TPR_2 PF07719.17 ETO14980.1 - 0.0055 16.7 1.0 4 7.8 0.1 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO14980.1 - 0.014 15.2 6.1 0.1 12.5 0.3 2.8 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO14980.1 - 0.021 15.7 0.7 0.067 14.1 0.2 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat PPR_2 PF13041.6 ETO14981.1 - 9.7e-09 35.3 0.4 0.0019 18.3 0.2 2.7 1 1 1 2 2 2 2 PPR repeat family PPR PF01535.20 ETO14981.1 - 1.7e-08 34.1 0.3 0.0022 18.1 0.0 2.6 2 0 0 2 2 2 2 PPR repeat PPR_1 PF12854.7 ETO14981.1 - 3.6e-06 26.5 0.1 0.0021 17.7 0.0 2.4 2 0 0 2 2 2 2 PPR repeat PPR_3 PF13812.6 ETO14981.1 - 7.9e-06 25.9 0.0 0.0012 18.9 0.0 2.5 1 1 1 2 2 2 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO14981.1 - 0.0053 16.1 0.0 0.014 14.8 0.0 1.7 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO14981.1 - 0.019 14.8 0.4 0.052 13.4 0.1 2.0 2 0 0 2 2 2 0 Mitochondrial ATPase expression GED PF02212.18 ETO14981.1 - 0.094 12.9 2.3 0.11 12.6 0.1 2.2 2 1 1 3 3 3 0 Dynamin GTPase effector domain Hid1 PF12722.7 ETO14982.1 - 0.52 8.4 10.6 0.72 7.9 10.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein WD40 PF00400.32 ETO14985.1 - 2.8e-08 34.3 1.3 6.5e-08 33.1 1.3 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO14985.1 - 0.00014 20.6 0.2 0.00015 20.6 0.2 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 BLF1 PF17752.1 ETO14985.1 - 0.0088 15.4 0.4 0.0092 15.3 0.4 1.1 1 0 0 1 1 1 1 Burkholderia lethal factor 1 ANAPC4_WD40 PF12894.7 ETO14985.1 - 0.081 13.2 0.0 0.13 12.6 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO14986.1 - 5e-06 27.2 0.6 3.7e-05 24.4 0.9 2.2 2 1 0 2 2 2 1 WD domain, G-beta repeat GRIN_C PF15235.6 ETO14987.1 - 0.49 10.6 6.8 3.5 7.9 6.8 2.1 1 1 0 1 1 1 0 G protein-regulated inducer of neurite outgrowth C-terminus Dicty_REP PF05086.12 ETO14987.1 - 3.9 5.3 5.6 3.2 5.6 5.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein VWA PF00092.28 ETO14988.1 - 0.0069 16.6 0.0 0.012 15.9 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain GTPase_binding PF09027.10 ETO14988.1 - 0.017 15.1 0.1 0.042 13.8 0.1 1.6 1 0 0 1 1 1 0 GTPase binding DUF3439 PF11921.8 ETO14990.1 - 0.029 14.3 8.2 0.045 13.7 8.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO14990.1 - 0.057 13.4 11.2 0.076 13.0 11.2 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 ETO14990.1 - 0.069 11.1 4.2 0.075 11.0 4.2 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 ETO14990.1 - 0.088 11.0 7.6 0.1 10.8 7.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF1667 PF07892.11 ETO14990.1 - 0.75 9.9 4.1 1.6 8.9 2.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1667) NCD3G PF07562.14 ETO14991.1 - 0.0054 16.7 3.0 0.017 15.1 3.0 1.8 1 0 0 1 1 1 1 Nine Cysteines Domain of family 3 GPCR MRP-L51 PF10244.9 ETO14991.1 - 0.093 13.0 0.0 0.31 11.3 0.0 1.9 1 0 0 1 1 1 0 Mitochondrial ribosomal subunit Chlam_PMP PF02415.17 ETO14991.1 - 0.11 13.0 22.6 0.82 10.3 2.2 6.2 6 0 0 6 6 6 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat TRP PF06011.12 ETO14991.1 - 2.4 6.8 20.7 0.027 13.2 8.8 3.1 2 1 0 2 2 2 0 Transient receptor potential (TRP) ion channel DUF1054 PF06335.12 ETO14992.1 - 0.062 13.2 0.9 0.15 12.0 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1054) PolyA_pol_RNAbd PF12627.7 ETO14992.1 - 0.077 12.8 0.2 0.34 10.7 0.1 2.2 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A Nudix_hydro PF18290.1 ETO14994.1 - 1.7 8.7 5.6 27 4.8 0.2 2.9 2 0 0 2 2 2 0 Nudix hydrolase domain zf-H2C2_2 PF13465.6 ETO14995.1 - 2.1e-09 37.4 18.0 1.8e-06 28.1 1.6 4.1 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO14995.1 - 0.00015 22.3 25.7 0.059 14.2 3.9 4.5 3 0 0 3 3 3 3 C2H2-type zinc finger UPF0524 PF15823.5 ETO14995.1 - 0.006 16.0 4.9 0.006 16.0 4.9 2.8 3 0 0 3 3 3 1 UPF0524 of C3orf70 zf-C2H2 PF00096.26 ETO14995.1 - 0.21 12.1 25.1 0.7 10.5 2.8 4.3 3 0 0 3 3 3 0 Zinc finger, C2H2 type RBP_receptor PF14752.6 ETO14995.1 - 0.22 10.1 5.8 0.43 9.1 5.8 1.4 1 0 0 1 1 1 0 Retinol binding protein receptor ATP11 PF06644.11 ETO14995.1 - 1.8 8.3 25.0 6.2 6.5 14.2 2.8 2 0 0 2 2 2 0 ATP11 protein zf-AN1 PF01428.16 ETO14995.1 - 3.7 7.8 18.1 0.23 11.6 1.9 3.6 1 1 2 3 3 3 0 AN1-like Zinc finger zf-C2H2_jaz PF12171.8 ETO14995.1 - 6.6 7.1 14.9 16 6.0 1.5 4.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding DUF1840 PF08895.11 ETO14995.1 - 9.3 6.6 15.3 2.2 8.7 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) COMM_domain PF07258.14 ETO14996.1 - 2e-13 50.3 0.1 4.4e-13 49.1 0.1 1.6 1 0 0 1 1 1 1 COMM domain Tryp_alpha_amyl PF00234.22 ETO14996.1 - 0.15 12.5 0.4 0.78 10.2 0.1 2.1 2 0 0 2 2 2 0 Protease inhibitor/seed storage/LTP family DUF2027 PF09640.10 ETO14997.1 - 0.067 12.8 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF2027) PT PF04886.12 ETO14998.1 - 0.89 9.2 6.1 2.1 8.0 6.1 1.6 1 0 0 1 1 1 0 PT repeat Chlam_PMP PF02415.17 ETO14998.1 - 2 9.1 0.0 2 9.1 0.0 15.6 18 1 0 18 18 18 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat TPR_2 PF07719.17 ETO14999.1 - 0.02 15.0 0.2 0.033 14.3 0.2 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO14999.1 - 0.041 14.1 0.0 0.078 13.2 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO14999.1 - 0.057 13.7 0.1 0.12 12.6 0.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 CLN3 PF02487.17 ETO15000.1 - 0.44 9.5 1.6 0.53 9.3 1.6 1.0 1 0 0 1 1 1 0 CLN3 protein DUF3464 PF11947.8 ETO15000.1 - 0.96 9.2 4.6 1.1 9.0 4.6 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 OAD_gamma PF04277.13 ETO15001.1 - 0.009 16.6 0.8 0.023 15.3 0.1 2.0 2 0 0 2 2 2 1 Oxaloacetate decarboxylase, gamma chain OATP PF03137.20 ETO15001.1 - 0.18 10.1 5.6 0.036 12.4 1.7 1.7 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF1840 PF08895.11 ETO15001.1 - 0.31 11.4 12.7 1.2 9.5 0.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1840) FAM176 PF14851.6 ETO15001.1 - 0.42 10.3 5.3 8.6 6.0 0.1 2.5 2 0 0 2 2 2 0 FAM176 family DUF2615 PF11027.8 ETO15002.1 - 0.00071 19.7 0.1 0.0014 18.8 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) Amidase PF01425.21 ETO15002.1 - 0.0011 18.1 0.3 0.24 10.3 0.1 2.1 2 0 0 2 2 2 2 Amidase HSP70 PF00012.20 ETO15003.1 - 1.2e-95 321.0 5.0 1.5e-45 155.5 0.0 4.2 4 0 0 4 4 4 4 Hsp70 protein MreB_Mbl PF06723.13 ETO15003.1 - 0.029 13.2 1.2 12 4.6 0.0 3.7 4 0 0 4 4 4 0 MreB/Mbl protein Orf78 PF06024.12 ETO15003.1 - 0.099 13.0 1.3 3.1 8.2 0.1 3.3 3 0 0 3 3 3 0 Orf78 (ac78) DUF1843 PF08898.10 ETO15003.1 - 0.32 11.5 3.7 17 6.0 0.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) TMEM154 PF15102.6 ETO15003.1 - 2 8.3 6.4 3.1 7.7 0.3 2.9 3 0 0 3 3 3 0 TMEM154 protein family WD40 PF00400.32 ETO15005.1 - 1.2e-16 60.7 7.4 1.3e-05 25.9 0.4 4.1 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15005.1 - 0.0061 16.8 0.1 3.2 8.1 0.0 3.1 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15005.1 - 0.041 12.5 0.1 4.5 5.8 0.1 2.4 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Kelch_1 PF01344.25 ETO15006.1 - 2.4e-06 27.0 1.2 0.017 14.7 0.2 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO15006.1 - 4.1e-06 26.7 0.7 0.0004 20.3 0.0 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15006.1 - 0.00018 21.4 5.4 0.21 11.6 0.0 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 ETO15006.1 - 0.00077 19.7 5.8 0.35 11.2 0.0 4.6 4 1 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO15006.1 - 0.0042 17.0 4.7 1 9.5 0.4 3.9 4 1 0 4 4 4 2 Kelch motif Copine PF07002.16 ETO15007.1 - 1e-42 146.1 0.0 2.7e-21 76.1 0.0 2.2 2 0 0 2 2 2 2 Copine CSTF2_hinge PF14327.6 ETO15009.1 - 0.04 14.4 0.2 0.19 12.2 0.1 2.1 2 0 0 2 2 2 0 Hinge domain of cleavage stimulation factor subunit 2 DUF3439 PF11921.8 ETO15009.1 - 1 9.4 4.9 2.3 8.2 4.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) LRR_6 PF13516.6 ETO15010.1 - 4.6e-14 51.2 11.4 0.011 15.7 0.1 5.3 5 0 0 5 5 5 5 Leucine Rich repeat LRR_1 PF00560.33 ETO15010.1 - 1.9e-07 30.7 1.8 8.8 7.3 0.0 5.3 4 1 0 4 4 4 2 Leucine Rich Repeat LRR_4 PF12799.7 ETO15010.1 - 0.00023 21.5 6.7 0.35 11.4 0.4 4.4 4 2 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO15010.1 - 0.00035 20.3 7.4 0.9 9.4 1.3 4.1 4 1 0 4 4 4 3 Leucine rich repeat PIEZO PF15917.5 ETO15012.1 - 0.024 14.1 0.8 0.029 13.9 0.8 1.1 1 0 0 1 1 1 0 Piezo Golgin_A5 PF09787.9 ETO15012.1 - 0.027 14.0 6.9 0.033 13.7 6.9 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 zf-C4H2 PF10146.9 ETO15012.1 - 0.028 14.7 3.3 0.036 14.4 3.3 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein Rtf2 PF04641.12 ETO15012.1 - 0.034 13.5 5.6 0.047 13.1 5.6 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger VSG_B PF13206.6 ETO15012.1 - 0.042 13.1 5.7 0.052 12.8 5.7 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain Csm1_N PF18504.1 ETO15012.1 - 0.064 13.6 3.4 0.064 13.6 3.4 2.0 2 0 0 2 2 2 0 Csm1 N-terminal domain SlyX PF04102.12 ETO15012.1 - 0.068 13.8 2.2 0.16 12.6 2.2 1.6 1 0 0 1 1 1 0 SlyX SoDot-IcmSS PF16848.5 ETO15012.1 - 0.068 13.1 0.6 0.095 12.7 0.6 1.2 1 0 0 1 1 1 0 Substrate of the Dot/Icm secretion system, putative Zip PF02535.22 ETO15012.1 - 0.2 10.8 0.3 0.28 10.4 0.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Seryl_tRNA_N PF02403.22 ETO15012.1 - 0.26 11.6 5.6 0.58 10.4 5.6 1.5 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Ku_C PF03730.14 ETO15012.1 - 0.34 11.6 5.4 8.9 7.1 0.1 2.3 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm PGA2 PF07543.12 ETO15012.1 - 0.49 10.4 9.0 0.3 11.1 6.7 1.8 1 1 0 1 1 1 0 Protein trafficking PGA2 Vfa1 PF08432.10 ETO15012.1 - 0.78 10.1 6.1 1.2 9.4 6.1 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4407 PF14362.6 ETO15012.1 - 2.1 7.6 8.1 3.1 7.1 8.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HAUS6_N PF14661.6 ETO15012.1 - 4.2 6.9 7.3 5.6 6.5 7.4 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Peptidase_S49_N PF08496.10 ETO15012.1 - 7.6 6.6 7.9 18 5.4 7.9 1.8 1 1 0 1 1 1 0 Peptidase family S49 N-terminal Lebercilin PF15619.6 ETO15013.1 - 1.3e-05 25.0 27.3 0.0015 18.2 12.9 3.1 3 0 0 3 3 3 2 Ciliary protein causing Leber congenital amaurosis disease Seryl_tRNA_N PF02403.22 ETO15013.1 - 0.0002 21.5 25.4 0.25 11.6 0.8 4.1 3 1 1 4 4 4 2 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 ETO15013.1 - 0.00064 20.1 13.4 0.0018 18.7 3.3 4.4 2 1 1 3 3 2 2 Cell division protein ZapB DivIC PF04977.15 ETO15013.1 - 0.019 14.7 30.2 0.25 11.1 3.6 4.7 3 1 2 5 5 5 0 Septum formation initiator NUDE_C PF04880.13 ETO15013.1 - 0.043 14.3 1.5 0.043 14.3 1.5 3.1 2 1 1 3 3 3 0 NUDE protein, C-terminal conserved region Nnf1 PF03980.14 ETO15013.1 - 0.059 13.8 0.4 0.059 13.8 0.4 4.1 3 1 1 4 4 4 0 Nnf1 Herpes_BLRF2 PF05812.12 ETO15013.1 - 0.11 12.7 17.9 0.42 10.8 5.6 3.3 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein MHB PF16525.5 ETO15013.1 - 0.19 12.0 3.0 0.31 11.3 0.5 2.5 2 1 0 2 2 2 0 Haemophore, haem-binding CENP-F_leu_zip PF10473.9 ETO15013.1 - 0.2 11.6 34.8 0.25 11.4 3.7 3.2 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4763 PF15960.5 ETO15013.1 - 0.22 10.8 27.4 0.14 11.5 6.9 3.7 2 1 2 4 4 4 0 Domain of unknown function (DUF4763) TPR_MLP1_2 PF07926.12 ETO15013.1 - 0.28 11.2 37.1 0.64 10.1 3.5 3.4 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF812 PF05667.11 ETO15013.1 - 0.29 10.0 30.1 0.47 9.3 30.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Fib_alpha PF08702.10 ETO15013.1 - 0.32 11.2 27.6 1.1 9.4 10.0 2.8 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 ETO15013.1 - 0.39 10.0 30.3 0.47 9.7 15.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) HrpB2 PF09487.10 ETO15013.1 - 0.56 10.7 8.0 0.23 11.9 1.9 2.5 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB2) SOGA PF11365.8 ETO15013.1 - 0.74 11.0 23.1 0.51 11.5 2.9 3.5 1 1 2 3 3 3 0 Protein SOGA bZIP_1 PF00170.21 ETO15013.1 - 0.86 9.8 27.9 0.069 13.3 2.0 4.9 3 1 2 5 5 5 0 bZIP transcription factor ATG16 PF08614.11 ETO15013.1 - 1.2 9.4 32.3 2.3 8.4 21.6 2.8 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Cnn_1N PF07989.11 ETO15013.1 - 1.5 9.0 31.0 3.8 7.7 1.5 4.6 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 Leu_zip PF15294.6 ETO15013.1 - 1.8 8.0 30.2 5.7 6.4 17.6 2.5 1 1 1 2 2 2 0 Leucine zipper End3 PF12761.7 ETO15013.1 - 1.9 8.6 29.1 2.5 8.2 10.1 2.5 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Fez1 PF06818.15 ETO15013.1 - 2 8.8 32.0 3.1 8.2 8.7 2.8 1 1 1 2 2 1 0 Fez1 Filament PF00038.21 ETO15013.1 - 2.7 7.5 32.2 1.5 8.3 8.9 3.2 1 1 2 3 3 3 0 Intermediate filament protein DASH_Spc19 PF08287.11 ETO15013.1 - 2.7 7.9 28.5 1.3 8.9 5.9 3.1 1 1 2 3 3 3 0 Spc19 TMF_DNA_bd PF12329.8 ETO15013.1 - 3 7.9 30.0 0.13 12.2 3.3 4.6 3 1 2 5 5 5 0 TATA element modulatory factor 1 DNA binding TMF_TATA_bd PF12325.8 ETO15013.1 - 3.3 8.0 31.7 0.33 11.2 0.4 4.1 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF724 PF05266.14 ETO15013.1 - 4.5 7.1 29.9 0.3 10.9 7.7 3.1 1 1 1 3 3 3 0 Protein of unknown function (DUF724) UPF0242 PF06785.11 ETO15013.1 - 4.9 7.2 39.8 3.7 7.6 6.0 3.1 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus AAA_31 PF13614.6 ETO15013.1 - 5.2 6.9 7.1 28 4.6 4.2 2.6 2 1 0 2 2 2 0 AAA domain Trimer_CC PF08954.11 ETO15013.1 - 5.3 6.7 9.3 2.8 7.6 0.3 3.3 3 0 0 3 3 3 0 Trimerisation motif LapA_dom PF06305.11 ETO15013.1 - 5.9 6.8 13.6 14 5.6 0.5 3.7 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Swi5 PF07061.11 ETO15013.1 - 6 7.0 23.8 0.7 10.0 2.5 4.4 2 1 1 3 3 3 0 Swi5 Mto2_bdg PF12808.7 ETO15013.1 - 6 7.2 17.9 8 6.8 1.2 3.9 4 0 0 4 4 4 0 Micro-tubular organiser Mto1 C-term Mto2-binding region GAS PF13851.6 ETO15013.1 - 8.3 5.7 38.9 4 6.8 6.1 3.8 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Sas6_CC PF18594.1 ETO15013.1 - 9.6 6.1 17.6 1.7 8.5 3.3 3.7 3 0 0 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain HAUS-augmin3 PF14932.6 ETO15014.1 - 0.00072 19.2 6.4 0.00092 18.9 6.4 1.1 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 CCDC-167 PF15188.6 ETO15014.1 - 0.019 15.3 2.3 0.019 15.3 2.3 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Seryl_tRNA_N PF02403.22 ETO15014.1 - 0.03 14.5 9.2 0.052 13.8 4.1 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain TMIE PF16038.5 ETO15014.1 - 0.2 11.5 4.2 0.2 11.5 0.4 2.2 1 1 0 2 2 2 0 TMIE protein Ribosomal_L29 PF00831.23 ETO15014.1 - 0.65 10.0 7.5 0.66 10.0 3.5 2.9 2 1 0 2 2 2 0 Ribosomal L29 protein OTU PF02338.19 ETO15014.1 - 1.7 9.1 4.8 9.1 6.8 4.8 2.0 1 1 0 1 1 1 0 OTU-like cysteine protease DUF4140 PF13600.6 ETO15014.1 - 6.6 7.2 8.1 3.6 8.1 1.3 2.1 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) bZIP_2 PF07716.15 ETO15014.1 - 8.1 6.6 12.9 3.9 7.6 1.5 3.0 3 0 0 3 3 3 0 Basic region leucine zipper TLD PF07534.16 ETO15017.1 - 2.8e-29 102.1 0.7 8.1e-29 100.6 0.7 1.9 1 0 0 1 1 1 1 TLD PH_TFIIH PF08567.11 ETO15017.1 - 0.00018 21.8 5.0 0.3 11.4 0.1 3.7 2 2 1 3 3 3 2 TFIIH p62 subunit, N-terminal domain PH_BEACH PF14844.6 ETO15017.1 - 0.027 14.5 2.3 3.4 7.8 0.0 3.1 3 0 0 3 3 3 0 PH domain associated with Beige/BEACH Hexose_dehydrat PF03559.14 ETO15018.1 - 0.048 13.1 0.0 0.072 12.5 0.0 1.2 1 0 0 1 1 1 0 NDP-hexose 2,3-dehydratase FAT PF02259.23 ETO15019.1 - 0.0015 17.8 0.0 0.0028 17.0 0.0 1.4 1 1 0 1 1 1 1 FAT domain PI3_PI4_kinase PF00454.27 ETO15020.1 - 4.3e-50 170.9 1.3 7.9e-50 170.0 1.3 1.4 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ETO15020.1 - 4.6e-13 48.7 0.1 9.3e-13 47.8 0.1 1.6 1 0 0 1 1 1 1 FATC domain PAS_6 PF08348.11 ETO15020.1 - 0.12 12.2 2.0 0.74 9.7 0.1 2.8 2 0 0 2 2 2 0 YheO-like PAS domain YlbD_coat PF14071.6 ETO15021.1 - 0.036 14.3 0.9 0.036 14.3 0.9 2.0 2 1 0 2 2 2 0 Putative coat protein DUF740 PF05340.12 ETO15021.1 - 0.038 12.7 1.3 0.044 12.5 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) DUF5011 PF16403.5 ETO15023.1 - 0.28 11.3 2.1 0.61 10.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5011) zf-DNL PF05180.12 ETO15024.1 - 2.7e-20 72.1 1.2 2.7e-20 72.1 1.2 1.8 2 0 0 2 2 2 1 DNL zinc finger AsiA PF09010.10 ETO15024.1 - 0.026 14.6 0.1 0.054 13.6 0.1 1.5 1 0 0 1 1 1 0 Anti-Sigma Factor A FERM_N_2 PF18038.1 ETO15024.1 - 0.12 13.2 2.6 0.66 10.8 0.2 2.4 1 1 1 2 2 2 0 FERM N-terminal domain UPF0167 PF03691.14 ETO15024.1 - 0.14 11.9 5.7 0.17 11.7 0.8 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0167) LMBR1 PF04791.16 ETO15024.1 - 0.6 9.0 1.8 0.63 8.9 1.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Eapp_C PF10238.9 ETO15024.1 - 0.73 9.9 8.8 0.075 13.1 3.5 1.9 2 0 0 2 2 2 0 E2F-associated phosphoprotein DUF3464 PF11947.8 ETO15024.1 - 1.4 8.7 5.2 0.16 11.7 0.6 1.7 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Tubulin_C PF03953.17 ETO15025.1 - 1.4e-30 106.0 0.0 2.2e-30 105.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO15025.1 - 2.1e-26 93.4 0.3 4.6e-26 92.3 0.2 1.6 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain TRP_2 PF08344.11 ETO15025.1 - 0.035 14.3 0.2 0.63 10.3 0.0 2.6 3 0 0 3 3 3 0 Transient receptor ion channel II RhoGEF PF00621.20 ETO15026.1 - 2.3e-15 57.3 8.2 3.4e-15 56.8 8.2 1.2 1 0 0 1 1 1 1 RhoGEF domain Tubulin_C PF03953.17 ETO15027.1 - 0.003 17.7 0.0 0.0039 17.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain WD40 PF00400.32 ETO15028.1 - 2e-21 75.9 14.0 4.7e-07 30.4 2.2 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO15028.1 - 4.8e-06 25.5 0.5 0.0019 16.9 0.3 2.5 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15028.1 - 6.6e-06 26.3 0.1 0.0034 17.6 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CENP-B_dimeris PF09026.10 ETO15030.1 - 0.39 11.1 6.5 0.33 11.3 2.9 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ATAD4 PF15321.6 ETO15030.1 - 4.6 8.6 14.2 0.081 14.3 4.1 2.7 1 1 1 2 2 2 0 ATPase family AAA domain containing 4 Ank_4 PF13637.6 ETO15031.1 - 1.4e-14 54.3 0.6 0.0024 18.4 0.0 4.8 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO15031.1 - 1.9e-14 54.0 1.1 5.5e-08 33.3 0.1 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) DEP PF00610.21 ETO15031.1 - 6.6e-14 51.7 0.1 3.2e-13 49.5 0.1 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Ank_5 PF13857.6 ETO15031.1 - 5e-09 36.3 18.1 0.00063 20.0 0.2 5.4 4 2 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 ETO15031.1 - 2.4e-05 24.5 1.2 1.2 9.7 0.0 3.9 3 1 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETO15031.1 - 3.2e-05 24.0 4.0 2.7 8.8 0.1 5.2 4 0 0 4 4 4 1 Ankyrin repeat Neisseria_TspB PF05616.13 ETO15031.1 - 2.9 6.3 10.0 3.3 6.1 8.8 1.7 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein Ank_2 PF12796.7 ETO15032.1 - 3.6e-37 126.8 3.9 4.8e-15 55.9 0.6 4.2 3 1 1 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ETO15032.1 - 4.3e-29 99.7 10.9 1.1e-05 25.6 0.1 7.4 7 0 0 7 7 7 6 Ankyrin repeat Ank_5 PF13857.6 ETO15032.1 - 3.8e-27 94.0 8.8 4.6e-07 30.0 0.3 7.0 2 1 5 7 7 7 7 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO15032.1 - 1.4e-25 89.3 7.0 1.8e-09 37.9 0.1 6.8 3 2 5 8 8 8 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO15032.1 - 1.1e-21 74.5 7.7 0.00075 19.8 0.0 8.4 9 0 0 9 9 9 5 Ankyrin repeat SAM_3 PF18016.1 ETO15033.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SIR2 PF02146.17 ETO15033.1 - 0.12 12.3 0.7 0.4 10.6 0.2 1.9 2 0 0 2 2 2 0 Sir2 family SR-25 PF10500.9 ETO15034.1 - 0.026 14.2 8.2 0.029 14.0 8.2 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein BK_channel_a PF03493.18 ETO15034.1 - 0.07 13.3 0.1 0.1 12.8 0.1 1.4 1 1 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit DUF2115 PF09888.9 ETO15035.1 - 1.6 9.3 9.6 2 8.9 6.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) TPR_12 PF13424.6 ETO15036.1 - 1.1e-23 83.3 0.5 2.5e-14 53.3 0.0 3.2 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO15036.1 - 1.8e-16 58.8 2.6 1.2e-05 25.0 0.0 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO15036.1 - 6.3e-15 54.0 0.0 0.00042 20.1 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO15036.1 - 1.3e-14 53.3 12.0 4.1e-09 35.9 0.2 4.3 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO15036.1 - 7.8e-14 50.7 9.9 0.0001 22.3 0.5 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO15036.1 - 4.1e-11 42.4 0.0 0.04 13.8 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO15036.1 - 9.9e-09 35.3 0.6 0.13 13.0 0.0 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat SNAP PF14938.6 ETO15036.1 - 5.1e-07 29.4 0.5 8.7e-07 28.6 0.5 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO15036.1 - 1.5e-06 27.7 5.2 0.0068 16.1 0.1 4.6 3 2 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 ETO15036.1 - 1.8e-06 27.9 2.0 0.28 11.6 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO15036.1 - 0.00011 22.2 0.4 0.12 12.5 0.2 3.1 2 1 1 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO15036.1 - 0.00014 22.4 0.0 1.9 9.5 0.0 3.9 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO15036.1 - 0.00028 21.5 0.0 0.34 11.6 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO15036.1 - 0.034 14.8 0.5 12 6.7 0.0 3.2 4 0 0 4 4 2 0 Sel1 repeat AAA_lid_9 PF17871.1 ETO15036.1 - 0.054 13.4 0.0 0.26 11.2 0.0 2.1 2 0 0 2 2 2 0 AAA lid domain TPR_MalT PF17874.1 ETO15036.1 - 0.063 12.6 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 MalT-like TPR region Peptidase_C26 PF07722.13 ETO15037.1 - 3.7e-11 43.2 0.0 4.4e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase C26 GATase PF00117.28 ETO15037.1 - 0.00012 21.9 0.0 0.00015 21.6 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I WD40 PF00400.32 ETO15038.1 - 3.7e-05 24.4 10.4 0.0011 19.7 1.2 3.4 4 1 0 4 4 4 2 WD domain, G-beta repeat MMM1 PF10296.9 ETO15039.1 - 0.054 12.5 0.1 0.072 12.1 0.1 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 7TM_GPCR_Srv PF10323.9 ETO15039.1 - 0.13 11.6 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv EphA2_TM PF14575.6 ETO15039.1 - 0.23 12.3 2.1 0.75 10.7 2.1 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Kre28 PF17097.5 ETO15040.1 - 0.0028 16.7 5.1 0.0032 16.5 5.1 1.1 1 0 0 1 1 1 1 Spindle pole body component Exo_endo_phos PF03372.23 ETO15040.1 - 0.0045 16.5 0.0 0.0053 16.3 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SecM PF06558.12 ETO15040.1 - 0.053 13.6 0.0 0.071 13.2 0.0 1.3 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) TrwC PF08751.11 ETO15040.1 - 0.43 10.0 5.1 0.57 9.6 5.1 1.1 1 0 0 1 1 1 0 TrwC relaxase WRNPLPNID PF15017.6 ETO15040.1 - 2.2 9.2 6.3 4.6 8.2 6.3 1.5 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Tubulin-binding PF00418.19 ETO15041.1 - 0.0047 16.9 2.2 1.8 8.6 0.1 2.7 2 0 0 2 2 2 2 Tau and MAP protein, tubulin-binding repeat CAP_GLY PF01302.25 ETO15042.1 - 8.2e-06 25.7 0.1 1.3e-05 25.1 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain CENP-B_dimeris PF09026.10 ETO15042.1 - 0.62 10.5 5.6 0.89 10.0 5.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO15042.1 - 6.5 6.4 6.9 9.6 5.9 6.9 1.3 1 0 0 1 1 1 0 FAM176 family UBA_4 PF14555.6 ETO15043.1 - 0.031 14.1 0.1 0.055 13.3 0.1 1.3 1 0 0 1 1 1 0 UBA-like domain Ank_5 PF13857.6 ETO15043.1 - 0.11 12.9 0.0 0.2 12.0 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (many copies) LA-virus_coat PF09220.10 ETO15044.1 - 0.052 12.2 0.0 0.098 11.3 0.0 1.3 1 0 0 1 1 1 0 L-A virus, major coat protein NopRA1 PF16201.5 ETO15045.1 - 0.013 15.1 1.5 0.87 9.1 0.1 3.3 1 1 2 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 Arm PF00514.23 ETO15045.1 - 0.13 12.3 0.1 0.13 12.3 0.1 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RNA_pol_3_Rpc31 PF11705.8 ETO15045.1 - 2.2 8.5 6.4 4.7 7.4 6.4 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Atg14 PF10186.9 ETO15046.1 - 0.015 14.4 17.5 0.018 14.1 17.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 PPARgamma_N PF12577.8 ETO15046.1 - 1.2 9.8 5.2 3.1 8.5 0.1 2.6 1 1 0 2 2 2 0 PPAR gamma N-terminal region Zip PF02535.22 ETO15046.1 - 5.3 6.2 8.5 7.2 5.7 8.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Thymopoietin PF08198.11 ETO15048.1 - 0.039 13.6 0.0 0.079 12.6 0.0 1.4 1 0 0 1 1 1 0 Thymopoietin protein Tubulin PF00091.25 ETO15049.1 - 3.8e-46 157.8 0.0 4.3e-46 157.6 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain WD40 PF00400.32 ETO15050.1 - 1.2e-10 41.8 2.8 0.00031 21.5 0.1 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO15050.1 - 0.0047 15.7 1.8 0.057 12.2 0.2 2.0 1 1 1 2 2 2 2 Nup133 N terminal like Nup160 PF11715.8 ETO15050.1 - 0.0093 14.7 0.1 1.2 7.7 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Raftlin PF15250.6 ETO15051.1 - 0.37 9.5 4.6 0.42 9.3 4.6 1.2 1 0 0 1 1 1 0 Raftlin Macoilin PF09726.9 ETO15051.1 - 0.91 8.0 8.1 1.1 7.7 8.1 1.0 1 0 0 1 1 1 0 Macoilin family NST1 PF13945.6 ETO15051.1 - 1.5 8.9 9.2 0.59 10.2 7.0 1.4 2 0 0 2 2 2 0 Salt tolerance down-regulator Pneumo_att_G PF05539.11 ETO15051.1 - 1.8 8.1 7.3 2.6 7.6 7.3 1.2 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G WD40 PF00400.32 ETO15052.1 - 1.5e-12 47.8 7.5 5.4e-06 27.0 1.1 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF4407 PF14362.6 ETO15052.1 - 2 7.7 14.8 3.8 6.8 14.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DDHD PF02862.17 ETO15052.1 - 2.5 8.2 15.5 0.74 9.9 11.7 1.8 1 1 1 2 2 2 0 DDHD domain CSRNP_N PF16019.5 ETO15053.1 - 7.6e-10 39.1 17.8 0.00098 19.1 3.6 3.5 3 0 0 3 3 3 3 Cysteine/serine-rich nuclear protein N-terminus FAM76 PF16046.5 ETO15054.1 - 0.0041 16.5 13.5 0.0041 16.5 13.5 2.7 3 0 0 3 3 3 1 FAM76 protein Mss4 PF04421.13 ETO15054.1 - 0.028 14.5 0.2 0.028 14.5 0.2 2.9 3 1 0 3 3 3 0 Mss4 protein WD40 PF00400.32 ETO15055.1 - 2.1e-40 135.9 20.2 3.5e-08 34.0 0.2 8.5 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15055.1 - 4.4e-16 59.0 7.7 0.0031 17.8 0.0 7.6 2 1 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15055.1 - 6.3e-15 54.9 3.3 0.0014 17.6 0.1 6.2 2 1 5 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO15055.1 - 3e-08 33.4 0.2 0.0058 16.5 0.0 4.6 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO15055.1 - 0.0002 20.8 1.8 0.66 9.3 0.1 4.1 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Kelch_4 PF13418.6 ETO15055.1 - 0.00028 20.8 0.0 0.0027 17.7 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Hema_esterase PF03996.15 ETO15055.1 - 0.0018 18.1 0.0 0.004 17.0 0.0 1.5 1 0 0 1 1 1 1 Hemagglutinin esterase Kelch_1 PF01344.25 ETO15055.1 - 0.013 15.0 1.7 2 8.0 0.2 3.5 3 0 0 3 3 3 0 Kelch motif GF_recep_IV PF14843.6 ETO15055.1 - 0.015 15.1 0.7 0.046 13.5 0.7 1.8 1 0 0 1 1 1 0 Growth factor receptor domain IV DUF5570 PF17731.1 ETO15055.1 - 0.016 15.3 2.5 17 5.5 0.1 4.2 2 1 2 4 4 4 0 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO15055.1 - 0.016 14.8 0.4 0.045 13.3 0.4 1.8 1 1 0 1 1 1 0 PQQ-like domain Kelch_5 PF13854.6 ETO15055.1 - 0.048 13.7 0.8 1.1 9.4 0.2 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO15055.1 - 0.058 13.7 6.1 4.3 7.8 0.2 4.1 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO15056.1 - 9.7e-23 80.0 10.8 7.8e-08 32.9 0.4 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15056.1 - 8e-08 32.5 0.1 0.0025 18.1 0.0 3.2 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15056.1 - 1.5e-06 27.2 0.8 0.0054 15.4 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15056.1 - 6.1e-06 25.8 0.7 0.00045 19.6 0.2 2.3 1 1 2 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO15056.1 - 0.021 14.7 0.4 0.063 13.1 0.3 1.7 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A CspB_prodomain PF18425.1 ETO15056.1 - 0.022 14.7 0.5 0.044 13.8 0.5 1.5 1 0 0 1 1 1 0 Csp protease B prodomain Pkinase_C PF00433.24 ETO15057.1 - 1.8e-07 31.7 0.2 3.2e-07 30.9 0.2 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase PF00069.25 ETO15057.1 - 0.0047 16.3 0.0 0.0059 16.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO15058.1 - 1.5e-40 139.3 0.4 9.1e-40 136.7 0.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15058.1 - 8.4e-19 67.9 0.0 2.3e-15 56.6 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO15058.1 - 0.059 12.7 0.3 0.1 11.9 0.0 1.5 2 0 0 2 2 2 0 Kinase-like SRX PF09201.10 ETO15060.1 - 0.07 13.0 0.9 0.13 12.0 0.9 1.4 1 0 0 1 1 1 0 SRX, signal recognition particle receptor alpha subunit Pkinase PF00069.25 ETO15061.1 - 3.1e-07 30.1 0.7 5e-07 29.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15061.1 - 0.0021 17.4 0.3 0.0039 16.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase SIT PF15330.6 ETO15061.1 - 1 9.8 5.3 1.6 9.2 5.3 1.3 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT FancD2 PF14631.6 ETO15062.1 - 0.01 13.3 0.2 0.01 13.3 0.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease DUF2701 PF10857.8 ETO15062.1 - 0.076 13.1 2.2 0.15 12.1 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) MMM1 PF10296.9 ETO15063.1 - 0.019 14.0 4.4 0.029 13.4 4.4 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Exonuc_VII_L PF02601.15 ETO15063.1 - 0.073 12.6 3.5 0.08 12.5 3.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_11 PF13086.6 ETO15063.1 - 9 6.0 12.3 14 5.3 12.3 1.3 1 0 0 1 1 1 0 AAA domain PI3K_P85_iSH2 PF16454.5 ETO15064.1 - 0.012 15.2 4.9 0.012 15.2 4.9 7.6 1 1 4 7 7 7 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain GPS PF01825.21 ETO15066.1 - 0.0062 17.0 2.0 0.0062 17.0 2.0 2.2 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif MFS_3 PF05977.13 ETO15067.1 - 1.8 6.8 3.0 2.1 6.6 0.6 1.9 1 1 1 2 2 2 0 Transmembrane secretion effector DrsE_2 PF13686.6 ETO15068.1 - 0.026 14.4 0.8 0.088 12.7 0.4 2.0 2 0 0 2 2 2 0 DsrE/DsrF/DrsH-like family Phage_X PF05155.15 ETO15068.1 - 0.036 14.5 0.1 20 5.7 0.0 3.0 2 1 0 2 2 2 0 Phage X family Mitofilin PF09731.9 ETO15068.1 - 0.058 12.2 7.5 0.16 10.7 6.0 1.7 1 1 0 1 1 1 0 Mitochondrial inner membrane protein HSCB_C PF07743.13 ETO15068.1 - 0.094 13.2 8.5 0.25 11.9 0.6 3.2 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain HsbA PF12296.8 ETO15068.1 - 0.11 13.0 0.0 0.24 11.8 0.0 1.5 1 0 0 1 1 1 0 Hydrophobic surface binding protein A LON_substr_bdg PF02190.16 ETO15068.1 - 0.38 10.6 3.9 0.16 11.8 1.3 1.7 1 1 1 2 2 2 0 ATP-dependent protease La (LON) substrate-binding domain YtxH PF12732.7 ETO15068.1 - 1.9 9.1 6.1 6.2 7.4 3.0 2.9 2 1 0 2 2 2 0 YtxH-like protein Polo_box_3 PF18544.1 ETO15068.1 - 2.4 8.9 6.4 10 6.8 0.3 3.0 2 1 0 3 3 3 0 Polo box domain DUF1640 PF07798.11 ETO15068.1 - 2.4 8.2 10.3 6.2 6.8 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1640) SpmSyn_N PF17950.1 ETO15068.1 - 3.4 7.9 7.0 9.9 6.4 0.0 3.2 2 1 1 3 3 3 0 S-adenosylmethionine decarboxylase N -terminal ApoLp-III PF07464.11 ETO15068.1 - 8.9 6.4 10.8 5.5 7.1 2.6 2.8 3 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) ZZ PF00569.17 ETO15069.1 - 0.0013 18.5 0.8 0.0029 17.4 0.8 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type DUF493 PF04359.14 ETO15069.1 - 0.076 13.6 1.1 0.16 12.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF493) SecA_SW PF07516.13 ETO15069.1 - 0.15 12.1 6.9 2.3 8.2 1.0 2.1 1 1 1 2 2 2 0 SecA Wing and Scaffold domain ZapA PF05164.13 ETO15069.1 - 0.34 11.4 2.3 3.9 8.0 1.5 2.6 1 1 2 3 3 3 0 Cell division protein ZapA TetR_C_37 PF18665.1 ETO15069.1 - 0.96 10.1 7.1 1.4 9.6 2.1 2.2 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 ETO15070.1 - 6.7e-33 112.2 22.3 2.9e-06 27.9 0.5 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat CH PF00307.31 ETO15070.1 - 1.8e-12 47.4 1.3 9.6e-12 45.1 0.2 2.6 2 0 0 2 2 2 1 Calponin homology (CH) domain ANAPC4_WD40 PF12894.7 ETO15070.1 - 8.3e-10 38.8 1.2 0.17 12.2 0.0 5.8 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15070.1 - 3.4e-08 32.6 7.0 0.0037 16.0 0.8 5.2 2 2 1 4 4 4 4 Nucleoporin Nup120/160 WD40 PF00400.32 ETO15072.1 - 4.7e-32 109.5 22.1 1.2e-07 32.2 0.4 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15072.1 - 4.2e-15 55.8 0.1 0.058 13.7 0.0 5.1 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15072.1 - 4.1e-07 29.0 5.3 0.36 9.4 0.5 4.8 2 2 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15072.1 - 0.00012 21.5 9.5 0.69 9.2 0.2 5.3 2 2 2 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.11 ETO15072.1 - 0.00097 18.0 3.3 0.002 16.9 2.0 2.2 2 0 0 2 2 2 1 Nup133 N terminal like Phage_term_smal PF05944.12 ETO15072.1 - 0.18 11.8 1.3 0.31 11.0 1.3 1.3 1 0 0 1 1 1 0 Phage small terminase subunit BHD_1 PF10403.9 ETO15073.1 - 0.21 11.5 0.7 1.1 9.1 0.3 2.3 2 1 0 2 2 2 0 Rad4 beta-hairpin domain 1 CAP_GLY PF01302.25 ETO15075.1 - 0.058 13.4 0.1 0.86 9.7 0.1 2.5 1 1 0 1 1 1 0 CAP-Gly domain ABC_tran PF00005.27 ETO15077.1 - 1.1e-13 51.8 0.0 2e-13 51.0 0.0 1.4 1 0 0 1 1 1 1 ABC transporter DUF4092 PF13322.6 ETO15077.1 - 0.091 12.6 0.0 0.18 11.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4092) FragX_IP PF05994.11 ETO15078.1 - 3.2e-185 617.7 0.3 4.4e-185 617.2 0.3 1.1 1 0 0 1 1 1 1 Cytoplasmic Fragile-X interacting family MscS_TM PF12794.7 ETO15079.1 - 0.53 9.1 11.0 0.4 9.5 7.1 2.5 3 0 0 3 3 3 0 Mechanosensitive ion channel inner membrane domain 1 ABC2_membrane PF01061.24 ETO15080.1 - 2.1e-11 43.6 7.6 2.9e-11 43.2 7.6 1.1 1 0 0 1 1 1 1 ABC-2 type transporter EzrA PF06160.12 ETO15080.1 - 0.015 13.5 1.4 0.02 13.1 1.4 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA FYVE_2 PF02318.16 ETO15080.1 - 0.074 13.3 0.1 0.12 12.5 0.1 1.3 1 0 0 1 1 1 0 FYVE-type zinc finger Med21 PF11221.8 ETO15080.1 - 0.6 10.3 3.3 1 9.6 3.3 1.3 1 0 0 1 1 1 0 Subunit 21 of Mediator complex HALZ PF02183.18 ETO15082.1 - 0.0015 18.8 4.2 0.0024 18.1 4.2 1.3 1 0 0 1 1 1 1 Homeobox associated leucine zipper ZapB PF06005.12 ETO15082.1 - 0.0017 18.7 2.5 0.0017 18.7 2.5 2.0 2 1 0 2 2 2 1 Cell division protein ZapB YabA PF06156.13 ETO15082.1 - 0.0073 16.9 1.0 0.0073 16.9 1.0 2.2 2 1 0 2 2 2 1 Initiation control protein YabA DivIC PF04977.15 ETO15082.1 - 0.0091 15.7 1.7 0.021 14.6 1.7 1.6 1 0 0 1 1 1 1 Septum formation initiator Macoilin PF09726.9 ETO15082.1 - 0.018 13.7 18.9 0.02 13.5 18.9 1.0 1 0 0 1 1 1 0 Macoilin family DUF3450 PF11932.8 ETO15082.1 - 0.02 14.2 0.9 0.028 13.7 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) bZIP_1 PF00170.21 ETO15082.1 - 0.02 15.0 2.8 0.043 13.9 2.8 1.7 1 0 0 1 1 1 0 bZIP transcription factor TRAPPC-Trs85 PF12739.7 ETO15082.1 - 0.056 12.4 4.0 0.062 12.3 4.0 1.1 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit CCDC92 PF14916.6 ETO15082.1 - 0.068 12.9 1.9 1 9.2 1.9 2.5 1 1 1 2 2 2 0 Coiled-coil domain of unknown function APG6_N PF17675.1 ETO15082.1 - 0.087 13.3 6.1 0.12 12.9 6.1 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region NRBF2 PF08961.10 ETO15082.1 - 0.22 11.1 11.2 0.6 9.7 11.1 1.8 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Tmemb_cc2 PF10267.9 ETO15082.1 - 0.31 10.1 14.8 0.4 9.8 14.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein FAM76 PF16046.5 ETO15082.1 - 0.7 9.2 13.4 0.85 8.9 13.4 1.1 1 0 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 ETO15082.1 - 0.82 9.0 6.8 1.5 8.2 6.8 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Myc-LZ PF02344.15 ETO15082.1 - 0.97 9.6 5.0 0.88 9.7 2.2 2.4 2 1 1 3 3 3 0 Myc leucine zipper domain RAP1 PF07218.11 ETO15082.1 - 1.3 7.2 15.7 1.5 7.0 15.7 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) CENP-H PF05837.12 ETO15082.1 - 2.4 8.6 8.9 0.13 12.7 2.6 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Zip PF02535.22 ETO15082.1 - 6 6.0 7.6 5.6 6.1 7.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter TMF_DNA_bd PF12329.8 ETO15082.1 - 6.3 6.9 11.8 0.093 12.7 2.8 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Menin PF05053.13 ETO15082.1 - 7.8 4.7 13.5 8.3 4.6 13.5 1.2 1 0 0 1 1 1 0 Menin PH PF00169.29 ETO15083.1 - 2.2e-06 28.1 0.2 3e-06 27.7 0.2 1.2 1 0 0 1 1 1 1 PH domain FYVE PF01363.21 ETO15083.1 - 8.4e-05 22.6 0.9 0.00015 21.8 0.9 1.4 1 0 0 1 1 1 1 FYVE zinc finger DUF599 PF04654.12 ETO15083.1 - 0.087 12.2 0.0 0.16 11.3 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function, DUF599 FYVE_2 PF02318.16 ETO15084.1 - 0.016 15.4 3.5 0.016 15.4 3.5 3.9 3 2 1 4 4 4 0 FYVE-type zinc finger RhoGEF PF00621.20 ETO15086.1 - 0.0045 17.2 0.4 0.028 14.7 0.2 2.0 2 0 0 2 2 2 1 RhoGEF domain SURF6 PF04935.12 ETO15088.1 - 1.4e-07 31.5 13.5 1.4e-07 31.5 13.5 1.5 2 0 0 2 2 2 1 Surfeit locus protein 6 DUF3884 PF13024.6 ETO15088.1 - 0.05 13.2 0.2 0.13 11.8 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3884) DUF2358 PF10184.9 ETO15089.1 - 0.016 15.5 0.3 0.039 14.2 0.2 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) GAGBD PF16828.5 ETO15089.1 - 0.041 14.0 0.0 0.086 12.9 0.0 1.5 1 0 0 1 1 1 0 GAG-binding domain on surface antigen RhoGAP-FF1 PF16512.5 ETO15090.1 - 0.015 15.9 0.0 0.037 14.7 0.0 1.6 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain S4 PF01479.25 ETO15091.1 - 2.1e-06 27.4 0.7 2.1e-06 27.4 0.7 1.9 2 0 0 2 2 2 1 S4 domain Ribosomal_S4 PF00163.19 ETO15091.1 - 7.8e-06 26.7 1.3 1.4e-05 25.9 1.0 1.6 1 1 0 1 1 1 1 Ribosomal protein S4/S9 N-terminal domain Spore_YhcN_YlaJ PF09580.10 ETO15091.1 - 0.033 14.3 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) PSII_Pbs27 PF13326.6 ETO15093.1 - 0.013 15.9 1.0 0.017 15.4 1.0 1.3 1 0 0 1 1 1 0 Photosystem II Pbs27 AAA_23 PF13476.6 ETO15093.1 - 0.2 12.1 6.1 0.28 11.6 6.1 1.2 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 ETO15094.1 - 4e-97 315.4 38.1 2.1e-10 41.0 0.0 13.9 14 1 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15094.1 - 1.2e-31 108.9 11.0 0.0077 16.5 0.0 11.1 5 2 6 11 11 11 9 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15094.1 - 6.5e-17 61.4 20.2 0.11 11.1 0.0 10.3 5 2 5 11 11 11 9 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15094.1 - 9.7e-11 41.5 9.6 0.042 13.2 1.0 7.4 3 2 6 9 9 9 5 WD40-like domain Ge1_WD40 PF16529.5 ETO15094.1 - 8.7e-08 31.5 8.7 0.46 9.4 0.0 8.3 2 2 8 10 10 10 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO15094.1 - 3.3e-05 22.8 11.1 0.41 9.3 1.2 5.4 3 2 1 5 5 5 3 Nup133 N terminal like SBD PF17882.1 ETO15094.1 - 0.017 14.9 0.8 11 5.9 0.0 3.5 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain Imm17 PF15562.6 ETO15094.1 - 0.037 13.9 0.0 2.7 7.9 0.0 3.5 4 0 0 4 4 4 0 Immunity protein 17 PALB2_WD40 PF16756.5 ETO15094.1 - 1.1 8.1 8.4 8.9 5.1 0.0 5.6 5 2 3 8 8 8 0 Partner and localizer of BRCA2 WD40 domain zf-TRAF PF02176.18 ETO15095.1 - 0.00037 21.1 2.4 0.00037 21.1 2.4 2.7 3 1 1 4 4 4 1 TRAF-type zinc finger YMF19 PF02326.15 ETO15096.1 - 0.0009 20.0 3.9 0.0014 19.4 3.9 1.3 1 0 0 1 1 1 1 Plant ATP synthase F0 DFRP_C PF16543.5 ETO15097.1 - 0.81 10.2 8.8 0.25 11.9 1.2 2.2 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 Vac_Fusion PF02346.16 ETO15098.1 - 0.06 13.0 3.7 0.2 11.3 1.3 2.7 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 IL3 PF02059.15 ETO15099.1 - 0.21 11.6 5.9 0.24 11.5 5.9 1.1 1 0 0 1 1 1 0 Interleukin-3 Menin PF05053.13 ETO15099.1 - 6.5 5.0 10.9 6.7 4.9 10.9 1.0 1 0 0 1 1 1 0 Menin NST1 PF13945.6 ETO15099.1 - 7.7 6.6 13.5 8.8 6.4 13.5 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator Clat_adaptor_s PF01217.20 ETO15100.1 - 1.5e-51 174.0 3.9 1.9e-51 173.7 3.9 1.1 1 0 0 1 1 1 1 Clathrin adaptor complex small chain NCD2 PF04905.13 ETO15100.1 - 0.075 13.0 1.5 0.59 10.1 0.1 2.2 2 0 0 2 2 2 0 NAB conserved region 2 (NCD2) POC3_POC4 PF10448.9 ETO15101.1 - 0.048 13.7 0.6 0.15 12.1 0.1 2.1 2 0 0 2 2 2 0 20S proteasome chaperone assembly proteins 3 and 4 JAB PF01398.21 ETO15101.1 - 0.3 11.1 3.6 1.5 8.8 3.6 2.3 1 1 0 1 1 1 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease CiPC PF15800.5 ETO15101.1 - 3.8 7.2 11.5 0.19 11.5 5.4 1.7 2 0 0 2 2 2 0 Clock interacting protein circadian Papo_T_antigen PF02380.15 ETO15103.1 - 0.0037 17.4 6.8 0.009 16.1 6.8 1.8 1 0 0 1 1 1 1 T-antigen specific domain DUF2207 PF09972.9 ETO15103.1 - 1 8.0 3.1 1.7 7.3 3.1 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PH_12 PF16457.5 ETO15105.1 - 1.1e-06 29.2 0.4 1.1e-06 29.2 0.4 3.6 2 1 2 4 4 4 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO15105.1 - 0.0015 18.6 0.0 0.0048 17.0 0.0 1.8 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology Nop14 PF04147.12 ETO15105.1 - 0.3 9.2 30.7 0.006 14.9 22.8 2.0 2 0 0 2 2 2 0 Nop14-like family Sigma70_ner PF04546.13 ETO15105.1 - 5.6 6.8 21.1 0.11 12.4 7.2 3.7 3 1 0 4 4 4 0 Sigma-70, non-essential region Anoctamin PF04547.12 ETO15106.1 - 5.9e-34 117.7 27.9 2.8e-32 112.2 27.9 2.0 1 1 0 1 1 1 1 Calcium-activated chloride channel Anoctamin PF04547.12 ETO15107.1 - 3.5e-34 118.4 3.7 4.6e-34 118.0 3.7 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel sCache_like PF16736.5 ETO15107.1 - 0.021 14.9 2.5 0.044 13.9 2.5 1.5 1 0 0 1 1 1 0 Single Cache-like Pox_E10 PF04805.12 ETO15107.1 - 0.09 12.6 0.5 0.31 10.9 0.5 1.9 1 0 0 1 1 1 0 E10-like protein conserved region Orf78 PF06024.12 ETO15108.1 - 0.043 14.1 2.9 0.12 12.7 0.7 2.6 2 0 0 2 2 2 0 Orf78 (ac78) TMF_DNA_bd PF12329.8 ETO15109.1 - 0.0008 19.4 7.6 0.0008 19.4 7.6 4.4 3 1 1 4 4 4 2 TATA element modulatory factor 1 DNA binding HOOK PF05622.12 ETO15109.1 - 0.00082 17.7 40.3 0.0099 14.1 18.2 2.0 2 0 0 2 2 2 2 HOOK protein Spc7 PF08317.11 ETO15109.1 - 0.0072 15.2 12.7 0.0072 15.2 12.7 2.1 2 0 0 2 2 2 2 Spc7 kinetochore protein ADIP PF11559.8 ETO15109.1 - 0.012 15.7 9.3 0.012 15.7 9.3 3.9 2 2 2 4 4 4 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ETO15109.1 - 0.049 13.9 38.3 0.34 11.1 13.4 3.1 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Lebercilin PF15619.6 ETO15109.1 - 0.073 12.7 43.9 0.029 14.0 3.8 3.3 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Pox_A_type_inc PF04508.12 ETO15109.1 - 0.075 12.9 3.0 1.6 8.7 0.3 3.0 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat IFT57 PF10498.9 ETO15109.1 - 0.55 9.1 35.1 0.44 9.5 12.5 2.2 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Sec20 PF03908.13 ETO15109.1 - 0.67 9.9 14.0 0.2 11.6 3.0 3.8 2 1 2 4 4 4 0 Sec20 Prp19 PF08606.11 ETO15109.1 - 1.7 8.7 13.0 0.061 13.3 1.8 3.4 3 0 0 3 3 3 0 Prp19/Pso4-like Vac_Fusion PF02346.16 ETO15109.1 - 2.4 7.8 12.9 1.3 8.7 0.1 4.7 3 2 2 5 5 5 0 Chordopoxvirus multifunctional envelope protein A27 DUF4407 PF14362.6 ETO15109.1 - 3.9 6.8 25.8 0.61 9.4 10.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ERM PF00769.19 ETO15109.1 - 8.4 6.1 33.0 5.3 6.8 23.8 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family SAS-6_N PF16531.5 ETO15110.1 - 4.2e-22 78.5 5.7 4.2e-22 78.5 5.7 1.8 2 0 0 2 2 2 1 Centriolar protein SAS N-terminal PBD PF00786.28 ETO15110.1 - 0.11 12.9 1.5 0.83 10.1 0.2 2.8 2 2 0 2 2 2 0 P21-Rho-binding domain DUF5638 PF18688.1 ETO15110.1 - 3.4 8.0 11.1 0.37 11.1 2.9 3.0 4 0 0 4 4 4 0 Family of unknown function (DUF5638) AAA_31 PF13614.6 ETO15111.1 - 7.6e-20 71.5 1.4 9.6e-11 41.9 0.1 2.4 1 1 1 2 2 2 2 AAA domain MipZ PF09140.11 ETO15111.1 - 2.7e-13 49.8 0.0 2e-07 30.6 0.0 2.4 1 1 1 2 2 2 2 ATPase MipZ CbiA PF01656.23 ETO15111.1 - 4.7e-13 49.3 0.0 5.8e-13 49.0 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain VirC1 PF07015.11 ETO15111.1 - 7.7e-13 48.3 0.2 1.1e-12 47.8 0.2 1.2 1 0 0 1 1 1 1 VirC1 protein ParA PF10609.9 ETO15111.1 - 3.2e-10 39.9 0.2 1.4e-05 24.6 0.0 2.2 2 0 0 2 2 2 2 NUBPL iron-transfer P-loop NTPase ArsA_ATPase PF02374.15 ETO15111.1 - 2.5e-07 30.2 0.0 1.1e-06 28.0 0.0 2.0 1 1 1 2 2 2 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 ETO15111.1 - 0.00013 21.6 0.0 0.025 14.0 0.0 2.2 1 1 1 2 2 2 2 Cellulose biosynthesis protein BcsQ MeaB PF03308.16 ETO15111.1 - 0.00024 20.2 0.0 0.22 10.5 0.0 2.4 2 1 0 2 2 2 2 Methylmalonyl Co-A mutase-associated GTPase MeaB SRP54 PF00448.22 ETO15111.1 - 0.00078 19.1 0.1 0.002 17.8 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain CLP1_P PF16575.5 ETO15111.1 - 0.017 15.0 0.0 0.11 12.3 0.0 2.1 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop ATP_bind_1 PF03029.17 ETO15111.1 - 0.026 14.3 0.0 6.9 6.4 0.0 2.3 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein LZ3wCH PF18517.1 ETO15112.1 - 0.03 14.4 0.6 0.03 14.4 0.6 2.8 3 1 0 3 3 3 0 Leucine zipper with capping helix domain DUF4172 PF13776.6 ETO15113.1 - 0.032 14.6 3.2 6.1 7.2 0.2 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4172) EF-G-binding_N PF07299.11 ETO15114.1 - 0.06 13.9 2.3 0.17 12.4 1.7 2.0 1 1 0 1 1 1 0 Elongation factor G-binding protein, N-terminal SesA PF17107.5 ETO15115.1 - 0.077 13.2 0.7 0.43 10.8 0.3 2.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases THP2 PF09432.10 ETO15115.1 - 0.56 10.3 7.8 0.077 13.0 1.3 2.8 3 0 0 3 3 3 0 Tho complex subunit THP2 RHD3 PF05879.12 ETO15116.1 - 0.00014 20.2 11.9 0.00019 19.8 0.0 2.5 1 1 2 3 3 3 1 Root hair defective 3 GTP-binding protein (RHD3) Cytochrom_B562 PF07361.11 ETO15116.1 - 0.029 15.0 0.1 0.029 15.0 0.1 1.8 3 0 0 3 3 3 0 Cytochrome b562 DUF1539 PF07560.11 ETO15116.1 - 0.06 13.4 0.9 1.3 9.1 0.2 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) Dynamin_N PF00350.23 ETO15116.1 - 0.066 13.3 0.7 0.24 11.5 0.7 2.2 1 1 0 1 1 1 0 Dynamin family Zn_ribbon_2 PF12674.7 ETO15116.1 - 0.59 10.8 2.5 9.6 7.0 0.4 2.5 2 0 0 2 2 2 0 Putative zinc ribbon domain Kinesin PF00225.23 ETO15119.1 - 1.1e-23 83.7 0.0 1.4e-23 83.4 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO15119.1 - 3.1e-15 56.4 0.0 4.1e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Microtubule binding DNA_pol_phi PF04931.13 ETO15119.1 - 0.015 13.4 2.3 0.019 13.1 2.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO15119.1 - 0.036 13.4 3.5 0.05 12.9 3.5 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4611 PF15387.6 ETO15119.1 - 0.057 13.6 2.8 0.097 12.9 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Cwf_Cwc_15 PF04889.12 ETO15119.1 - 0.071 12.8 5.4 0.096 12.4 5.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein UPF0560 PF10577.9 ETO15119.1 - 0.12 10.9 0.3 0.1 11.1 0.3 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 AAA_22 PF13401.6 ETO15119.1 - 0.13 12.5 0.0 0.18 12.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain CENP-B_dimeris PF09026.10 ETO15119.1 - 0.17 12.3 8.4 0.33 11.4 8.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Dicty_REP PF05086.12 ETO15119.1 - 0.36 8.8 3.3 0.44 8.5 3.3 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein vATP-synt_E PF01991.18 ETO15120.1 - 1e-31 109.9 18.0 1e-31 109.9 18.0 1.7 1 1 1 2 2 2 1 ATP synthase (E/31 kDa) subunit BSMAP PF12280.8 ETO15122.1 - 0.056 13.6 0.1 0.082 13.1 0.1 1.3 1 0 0 1 1 1 0 Brain specific membrane anchored protein WD40 PF00400.32 ETO15123.1 - 4.8e-09 36.7 7.0 0.013 16.3 0.2 4.3 3 1 1 4 4 4 3 WD domain, G-beta repeat LAP1C PF05609.12 ETO15124.1 - 5.2 6.1 43.9 6.8 5.7 43.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DCB PF16213.5 ETO15125.1 - 4.4e-08 33.0 0.2 5.8e-08 32.6 0.2 1.3 1 0 0 1 1 1 1 Dimerisation and cyclophilin-binding domain of Mon2 Med26_C PF15693.5 ETO15126.1 - 0.03 14.5 3.6 0.038 14.2 3.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal PTPRCAP PF15713.5 ETO15126.1 - 0.083 13.2 8.6 0.11 12.8 8.6 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Presenilin PF01080.17 ETO15127.1 - 0.036 12.8 3.4 0.045 12.5 3.4 1.3 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO15128.1 - 8.5e-61 200.5 21.5 1.8e-09 38.1 0.1 8.3 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15128.1 - 3.8e-20 72.0 0.2 0.0064 16.8 0.0 6.6 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15128.1 - 6.3e-17 61.5 2.4 0.078 11.9 0.0 7.0 3 3 3 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO15128.1 - 5.2e-07 29.7 0.0 0.039 13.8 0.0 3.4 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO15128.1 - 1e-06 28.3 0.1 0.016 14.6 0.0 3.7 2 2 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO15128.1 - 6.5e-05 21.8 5.0 1.4 7.4 0.0 4.6 2 2 3 5 5 5 4 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO15128.1 - 0.00011 22.3 9.8 2.1 8.4 0.1 5.8 2 2 5 7 7 7 2 Family of unknown function (DUF5570) PD40 PF07676.12 ETO15128.1 - 0.018 15.0 11.4 15 5.6 0.0 7.2 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO15128.1 - 0.021 13.8 0.4 2.2 7.1 0.0 3.0 2 2 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETO15128.1 - 0.81 9.4 7.8 80 3.1 0.2 4.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Dynactin_p62 PF05502.13 ETO15129.1 - 0.19 10.5 0.5 0.22 10.2 0.5 1.0 1 0 0 1 1 1 0 Dynactin p62 family Pox_EPC_I2-L1 PF12575.8 ETO15131.1 - 1.1 9.5 6.5 0.21 11.8 0.3 2.8 3 0 0 3 3 3 0 Poxvirus entry protein complex L1 and I2 MFS_1 PF07690.16 ETO15133.1 - 0.0056 15.6 6.3 0.01 14.8 0.1 2.6 3 0 0 3 3 3 2 Major Facilitator Superfamily DUF3624 PF12292.8 ETO15134.1 - 0.8 10.2 4.4 0.99 9.9 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3624) Mob1_phocein PF03637.17 ETO15135.1 - 5.5e-77 257.6 0.1 9.2e-77 256.8 0.1 1.4 1 0 0 1 1 1 1 Mob1/phocein family SLC12 PF03522.15 ETO15136.1 - 1.3e-24 87.0 0.5 4e-13 49.2 0.0 2.7 2 1 0 2 2 2 2 Solute carrier family 12 APO_RNA-bind PF05634.11 ETO15136.1 - 0.043 13.2 0.0 0.081 12.3 0.0 1.4 1 0 0 1 1 1 0 APO RNA-binding TFIID_NTD2 PF04494.15 ETO15137.1 - 1.9 8.7 9.1 0.2 11.9 0.9 2.7 3 0 0 3 3 3 0 WD40 associated region in TFIID subunit, NTD2 domain WD40 PF00400.32 ETO15138.1 - 7.1e-43 143.8 21.1 3.8e-07 30.7 1.1 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15138.1 - 4.7e-11 42.8 9.0 0.043 14.1 0.0 6.3 5 3 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15138.1 - 5.2e-10 38.6 9.2 0.038 12.6 0.2 5.4 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15138.1 - 6.6e-05 22.4 9.3 0.03 13.7 1.5 4.7 2 2 2 4 4 4 3 WD40-like domain SAB PF04382.13 ETO15138.1 - 0.0072 16.4 1.6 0.0072 16.4 1.6 2.5 2 0 0 2 2 2 1 SAB domain PhoU PF01895.19 ETO15138.1 - 7.7 7.0 12.2 8.7 6.9 1.1 2.7 1 1 1 2 2 2 0 PhoU domain WD40 PF00400.32 ETO15139.1 - 6.3e-31 105.9 36.3 3.7e-07 30.7 0.6 6.2 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO15139.1 - 3.2e-07 29.4 8.1 0.0056 15.4 0.4 4.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15139.1 - 2.5e-06 27.7 1.6 0.31 11.4 0.0 4.5 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15139.1 - 0.00028 20.3 1.7 2.1 7.6 0.1 4.2 1 1 1 3 3 3 2 WD40-like domain TBSV_P22 PF03558.13 ETO15140.1 - 0.023 14.2 0.1 0.027 14.0 0.1 1.1 1 0 0 1 1 1 0 TBSV core protein P21/P22 Peptidase_C3 PF00548.20 ETO15141.1 - 0.045 13.7 0.9 0.054 13.4 0.9 1.3 1 0 0 1 1 1 0 3C cysteine protease (picornain 3C) LRS4 PF10422.9 ETO15141.1 - 0.085 12.4 1.1 0.088 12.4 1.1 1.2 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 Histone PF00125.24 ETO15142.1 - 2.7e-17 63.4 0.1 8e-17 61.8 0.0 1.7 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 Histone_H2A_C PF16211.5 ETO15142.1 - 2.6e-15 55.8 0.2 4.8e-15 55.0 0.2 1.4 1 0 0 1 1 1 1 C-terminus of histone H2A CBFD_NFYB_HMF PF00808.23 ETO15142.1 - 8.7e-07 29.1 0.0 1.3e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone YdfA_immunity PF12127.8 ETO15142.1 - 0.018 14.1 0.1 0.021 13.9 0.1 1.1 1 0 0 1 1 1 0 SigmaW regulon antibacterial LRR_4 PF12799.7 ETO15143.1 - 0.0027 18.1 7.4 0.33 11.5 0.7 4.4 4 0 0 4 4 4 1 Leucine Rich repeats (2 copies) SUIM_assoc PF16619.5 ETO15143.1 - 1.3 9.1 10.7 1.8 8.7 6.3 2.7 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 LRR_8 PF13855.6 ETO15143.1 - 2.4 8.0 4.8 21 5.0 0.1 3.5 3 0 0 3 3 3 0 Leucine rich repeat DUF1539 PF07560.11 ETO15143.1 - 3.7 7.7 9.6 0.59 10.2 0.8 3.2 3 1 0 3 3 3 0 Domain of Unknown Function (DUF1539) Ank_4 PF13637.6 ETO15145.1 - 1e-09 38.8 1.4 1.7e-06 28.5 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO15145.1 - 8e-09 36.0 0.1 4.1e-08 33.7 0.1 2.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO15145.1 - 4.1e-06 26.7 0.1 0.00018 21.7 0.0 3.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO15145.1 - 6.9e-06 26.2 0.2 5.4e-05 23.4 0.0 2.6 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO15145.1 - 1.8e-05 25.0 1.6 0.00011 22.5 0.0 3.3 4 0 0 4 4 4 1 Ankyrin repeat MerB PF03243.15 ETO15146.1 - 7.6e-10 39.0 0.1 1e-09 38.6 0.1 1.1 1 0 0 1 1 1 1 Alkylmercury lyase WD40 PF00400.32 ETO15147.1 - 8.4e-20 70.8 8.7 3.2e-05 24.6 0.7 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO15147.1 - 1.8e-07 30.2 0.5 0.066 11.8 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15147.1 - 2.1e-05 24.8 0.1 0.017 15.4 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Topoisom_bac PF01131.20 ETO15148.1 - 1.9e-95 320.3 5.3 5.6e-75 252.9 0.1 2.5 3 0 0 3 3 3 2 DNA topoisomerase SUIM_assoc PF16619.5 ETO15148.1 - 0.0061 16.6 3.6 0.12 12.5 3.3 2.8 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 Sre PF03125.18 ETO15148.1 - 0.29 10.2 1.9 3.8 6.6 0.1 2.4 2 0 0 2 2 2 0 C. elegans Sre G protein-coupled chemoreceptor Spt20 PF12090.8 ETO15148.1 - 0.84 9.2 13.3 0.058 13.0 8.3 1.6 2 0 0 2 2 2 0 Spt20 family WD40 PF00400.32 ETO15150.1 - 5.7e-29 99.8 14.3 4.9e-10 39.8 0.1 5.6 6 0 0 6 6 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15150.1 - 1.6e-13 50.7 0.0 0.0027 18.0 0.0 5.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO15150.1 - 4.8e-11 42.3 4.2 0.15 12.0 0.0 6.2 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO15150.1 - 3.9e-09 35.9 0.0 0.0029 16.6 0.0 3.7 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO15150.1 - 8.3e-05 22.7 0.3 3.5 7.7 0.0 3.8 2 1 2 4 4 4 2 Family of unknown function (DUF5570) eIF2A PF08662.11 ETO15150.1 - 0.0018 18.2 0.1 0.024 14.5 0.0 2.5 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO15150.1 - 0.0022 17.4 0.3 3.8 6.8 0.0 3.8 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO15150.1 - 0.017 14.7 0.0 0.16 11.5 0.0 2.0 1 1 0 1 1 1 0 PQQ-like domain FAINT PF04385.15 ETO15150.1 - 0.046 13.8 0.0 0.089 12.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function, DUF529 Nup160 PF11715.8 ETO15150.1 - 0.05 12.2 0.2 5 5.7 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Read-through PF16814.5 ETO15150.1 - 0.077 12.8 0.2 9.5 6.0 0.0 2.6 2 1 0 2 2 2 0 Read-through domain Proteasome_A_N PF10584.9 ETO15150.1 - 0.25 11.1 10.1 25 4.6 0.0 5.3 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO15151.1 - 4.5e-16 58.9 3.3 1.3e-06 29.0 0.5 5.8 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15151.1 - 6.2e-13 48.9 0.4 0.018 15.3 0.1 5.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO15151.1 - 5.7e-06 26.3 3.2 0.12 12.3 0.2 4.2 3 1 0 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO15151.1 - 5.8e-05 22.2 0.7 2.1 7.2 0.3 3.7 3 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO15151.1 - 8.9e-05 21.4 1.0 0.37 9.5 0.1 3.0 2 1 0 2 2 2 2 Nup133 N terminal like Nup160 PF11715.8 ETO15151.1 - 0.0001 21.1 1.2 0.018 13.7 0.1 2.3 2 0 0 2 2 2 2 Nucleoporin Nup120/160 Fringe PF02434.16 ETO15152.1 - 0.0038 16.7 0.1 0.006 16.1 0.1 1.3 1 0 0 1 1 1 1 Fringe-like SF-assemblin PF06705.11 ETO15153.1 - 0.013 14.9 1.7 0.03 13.7 1.7 1.6 1 0 0 1 1 1 0 SF-assemblin/beta giardin Peptidase_S66 PF02016.15 ETO15153.1 - 0.084 13.0 0.0 0.73 10.0 0.0 2.2 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain tRNA-synt_His PF13393.6 ETO15153.1 - 0.23 10.7 0.1 0.91 8.7 0.0 1.9 2 0 0 2 2 2 0 Histidyl-tRNA synthetase NusB PF01029.18 ETO15153.1 - 0.33 11.2 1.7 1.5 9.0 0.0 2.5 2 0 0 2 2 2 0 NusB family SAM35 PF10806.8 ETO15154.1 - 0.21 11.8 1.6 0.4 11.0 1.4 1.6 1 1 0 1 1 1 0 SAM35, subunit of SAM coomplex Nic96 PF04097.14 ETO15156.1 - 5.4e-20 71.4 4.0 6.7e-20 71.1 4.0 1.1 1 0 0 1 1 1 1 Nup93/Nic96 TRPM_tetra PF16519.5 ETO15156.1 - 0.078 13.1 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 Tetramerisation domain of TRPM ORC3_N PF07034.11 ETO15156.1 - 0.095 11.8 2.5 1.8 7.6 0.3 2.2 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 3 N-terminus Kelch_2 PF07646.15 ETO15157.1 - 1.1e-06 28.4 5.3 0.00016 21.5 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO15157.1 - 5.1e-05 23.2 2.1 1.9 8.5 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO15157.1 - 5.9e-05 23.2 4.7 1.4 9.3 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO15157.1 - 0.00022 21.2 0.1 0.3 11.1 0.1 3.4 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO15157.1 - 0.0087 15.6 2.5 0.58 9.8 0.1 4.4 6 1 0 6 6 6 1 Kelch motif TPR_12 PF13424.6 ETO15158.1 - 2.8e-22 78.8 0.4 3e-10 40.2 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO15158.1 - 5.7e-15 54.6 0.3 0.0004 20.2 0.0 4.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO15158.1 - 2.6e-08 33.3 3.3 0.022 14.7 0.0 4.7 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO15158.1 - 1.2e-07 31.3 28.9 2.7e-05 24.0 0.5 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO15158.1 - 1.2e-06 28.1 24.8 3.7e-06 26.5 0.5 4.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO15158.1 - 6.4e-05 22.8 18.3 0.016 15.2 0.5 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO15158.1 - 0.0021 17.7 8.5 0.017 14.8 0.7 3.6 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 ETO15158.1 - 0.058 13.8 2.9 22 5.7 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Defb50 PF17546.2 ETO15158.1 - 0.17 11.8 1.8 0.93 9.5 0.1 3.0 4 0 0 4 4 4 0 Beta defensin 50 DUF2063 PF09836.9 ETO15159.1 - 0.019 15.2 0.0 0.028 14.7 0.0 1.3 1 0 0 1 1 1 0 Putative DNA-binding domain DUF148 PF02520.17 ETO15159.1 - 0.11 12.6 7.1 3.4 7.8 5.4 2.3 1 1 1 2 2 2 0 Domain of unknown function DUF148 CorA PF01544.18 ETO15159.1 - 0.12 11.6 3.0 0.15 11.4 3.0 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Cauli_DNA-bind PF03310.13 ETO15159.1 - 0.28 11.3 6.4 8.2 6.5 0.1 2.1 2 0 0 2 2 2 0 Caulimovirus DNA-binding protein FlaC_arch PF05377.11 ETO15159.1 - 3.6 8.1 10.9 5.7 7.4 0.1 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF948 PF06103.11 ETO15159.1 - 5.8 7.3 6.1 18 5.7 4.4 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) NACHT PF05729.12 ETO15160.1 - 1e-07 32.0 0.0 2.1e-07 31.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain FYVE PF01363.21 ETO15161.1 - 1.3e-08 34.8 4.1 2.8e-08 33.8 4.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 ETO15161.1 - 0.004 17.6 0.1 2 8.9 0.0 2.6 2 0 0 2 2 2 2 PH domain PH_10 PF15411.6 ETO15161.1 - 0.017 15.4 1.3 0.042 14.1 0.1 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain Zip PF02535.22 ETO15161.1 - 0.19 10.9 3.8 0.25 10.5 3.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SelP_N PF04592.14 ETO15161.1 - 1.2 8.5 17.0 2.2 7.6 17.0 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region FYVE_2 PF02318.16 ETO15161.1 - 9.2 6.5 9.5 2.5 8.3 5.8 2.0 2 1 0 2 2 2 0 FYVE-type zinc finger SAM_1 PF00536.30 ETO15162.1 - 8.1e-15 55.0 0.5 1.3e-14 54.3 0.5 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO15162.1 - 1e-07 31.9 0.6 1.7e-07 31.2 0.6 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3139 PF11337.8 ETO15162.1 - 0.011 16.4 5.5 0.019 15.6 5.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) EphA2_TM PF14575.6 ETO15162.1 - 0.018 15.9 0.1 0.025 15.4 0.1 1.3 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 ETO15162.1 - 0.04 14.9 0.3 0.06 14.3 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Shisa PF13908.6 ETO15162.1 - 0.094 13.0 1.0 0.12 12.7 1.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF5305 PF17231.2 ETO15162.1 - 1 8.7 7.6 1.6 8.1 7.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) NTP_transf_2 PF01909.23 ETO15163.1 - 4.5e-05 23.7 0.0 0.00022 21.4 0.0 2.1 2 1 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO15163.1 - 0.053 13.6 1.9 0.097 12.8 0.1 2.4 2 1 1 3 3 3 0 Polymerase beta, Nucleotidyltransferase zf-trcl PF13451.6 ETO15165.1 - 0.051 13.5 0.1 0.18 11.7 0.1 1.9 1 0 0 1 1 1 0 Probable zinc-ribbon domain ROF PF07073.12 ETO15166.1 - 0.058 13.6 0.3 0.11 12.6 0.1 1.7 2 1 0 2 2 2 0 Modulator of Rho-dependent transcription termination (ROF) HC2 PF07382.11 ETO15167.1 - 0.0016 18.6 9.1 0.002 18.2 9.1 1.2 1 0 0 1 1 1 1 Histone H1-like nucleoprotein HC2 EpoR_lig-bind PF09067.10 ETO15169.1 - 0.0053 16.9 0.8 0.0099 16.1 0.8 1.5 1 0 0 1 1 1 1 Erythropoietin receptor, ligand binding CxC7 PF18866.1 ETO15169.1 - 0.0095 16.1 0.8 0.022 14.9 0.8 1.6 1 1 0 1 1 1 1 CxC7 like cysteine cluster associated with KDZ transposases YqfQ PF14181.6 ETO15170.1 - 8.3 6.6 8.2 9.3 6.4 8.2 1.1 1 0 0 1 1 1 0 YqfQ-like protein Ly-6_related PF06579.12 ETO15172.1 - 0.0029 17.8 1.4 1.2 9.4 0.0 2.2 1 1 1 2 2 2 2 Caenorhabditis elegans ly-6-related protein Ank_5 PF13857.6 ETO15172.1 - 0.0031 17.8 0.1 0.015 15.6 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO15172.1 - 0.0042 17.5 2.3 0.53 11.0 0.0 4.5 6 0 0 6 6 6 1 Ankyrin repeat DNA_pol_E_B PF04042.16 ETO15172.1 - 0.016 14.6 0.7 0.19 11.0 0.0 2.4 2 1 0 2 2 2 0 DNA polymerase alpha/epsilon subunit B Ank_2 PF12796.7 ETO15172.1 - 0.03 14.9 0.9 0.19 12.3 0.4 2.6 1 1 2 3 3 3 0 Ankyrin repeats (3 copies) Xol-1_N PF09108.10 ETO15172.1 - 0.046 13.6 0.1 0.067 13.0 0.1 1.3 1 0 0 1 1 1 0 Switch protein XOL-1, N-terminal Ank_4 PF13637.6 ETO15172.1 - 0.084 13.5 1.0 21 5.9 0.2 3.3 3 1 1 4 4 4 0 Ankyrin repeats (many copies) Rrn6 PF10214.9 ETO15173.1 - 0.47 8.9 5.3 0.53 8.7 5.3 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1430 PF07242.11 ETO15174.1 - 0.0016 18.7 4.1 0.9 9.8 0.3 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1430) DUF3139 PF11337.8 ETO15174.1 - 0.012 16.3 1.1 0.012 16.3 1.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Serinc PF03348.15 ETO15174.1 - 0.014 14.3 0.1 0.023 13.7 0.1 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Peptidase_S49_N PF08496.10 ETO15174.1 - 0.1 12.6 3.4 0.19 11.8 3.4 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4446 PF14584.6 ETO15174.1 - 0.26 11.3 3.1 0.48 10.4 3.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) SR-25 PF10500.9 ETO15175.1 - 2.2 7.8 12.3 3.2 7.3 12.3 1.2 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF2431 PF10354.9 ETO15176.1 - 2.3e-10 41.0 1.1 5.5e-10 39.8 1.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF2431) DUF1280 PF06918.14 ETO15176.1 - 0.01 15.5 0.9 0.012 15.2 0.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1280) DUF713 PF05218.14 ETO15177.1 - 0.012 15.4 0.1 0.024 14.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF713) RIH_assoc PF08454.11 ETO15177.1 - 0.71 9.8 3.2 0.26 11.2 0.1 1.9 3 0 0 3 3 3 0 RyR and IP3R Homology associated Golgin_A5 PF09787.9 ETO15178.1 - 2.1 7.8 45.4 0.38 10.2 32.2 2.6 2 1 0 2 2 2 0 Golgin subfamily A member 5 HAUS-augmin3 PF14932.6 ETO15178.1 - 6.8 6.2 41.5 0.093 12.3 19.3 3.2 2 1 1 3 3 3 0 HAUS augmin-like complex subunit 3 DUF1217 PF06748.12 ETO15179.1 - 0.066 13.3 0.4 0.11 12.5 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1217) ZapB PF06005.12 ETO15179.1 - 4 8.0 11.9 0.68 10.4 7.1 2.2 2 0 0 2 2 2 0 Cell division protein ZapB DUF1759 PF03564.15 ETO15179.1 - 7.5 6.5 9.9 0.42 10.5 1.1 2.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1759) HOOK PF05622.12 ETO15180.1 - 0.00036 18.8 11.5 0.0012 17.1 0.2 2.1 2 0 0 2 2 2 2 HOOK protein DUF3972 PF13118.6 ETO15180.1 - 0.0077 16.7 1.0 0.0077 16.7 1.0 2.1 2 1 0 2 2 2 1 Protein of unknown function (DUF3972) SPX PF03105.19 ETO15180.1 - 0.045 13.7 30.9 2.8 7.8 28.3 2.1 1 1 1 2 2 2 0 SPX domain PKcGMP_CC PF16808.5 ETO15180.1 - 0.049 13.5 0.9 0.049 13.5 0.9 2.8 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase SID-1_RNA_chan PF13965.6 ETO15180.1 - 0.11 10.9 0.1 0.11 10.9 0.1 3.1 3 1 0 3 3 3 0 dsRNA-gated channel SID-1 SieB PF14163.6 ETO15180.1 - 0.34 10.4 4.7 0.19 11.2 0.3 2.5 2 0 0 2 2 2 0 Super-infection exclusion protein B Golgin_A5 PF09787.9 ETO15180.1 - 1.4 8.3 21.2 0.14 11.6 11.4 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 SlyX PF04102.12 ETO15180.1 - 4.6 7.9 9.0 23 5.7 2.9 2.7 2 0 0 2 2 2 0 SlyX DUF4407 PF14362.6 ETO15180.1 - 8.2 5.7 13.2 3 7.1 0.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) MMR_HSR1 PF01926.23 ETO15181.1 - 1e-09 38.5 0.0 1.6e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO15181.1 - 0.00041 19.9 0.0 0.00076 19.0 0.0 1.5 2 0 0 2 2 2 1 Ferrous iron transport protein B Dynamin_N PF00350.23 ETO15181.1 - 0.00061 19.9 0.1 0.0014 18.7 0.0 1.6 2 0 0 2 2 2 1 Dynamin family AIG1 PF04548.16 ETO15181.1 - 0.019 14.3 0.1 0.031 13.6 0.0 1.4 2 0 0 2 2 2 0 AIG1 family RsgA_GTPase PF03193.16 ETO15181.1 - 0.037 13.9 0.0 0.041 13.8 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase ABC_tran PF00005.27 ETO15181.1 - 0.051 14.1 0.1 0.092 13.3 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_15 PF13175.6 ETO15181.1 - 0.058 13.1 0.2 0.1 12.3 0.2 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_24 PF13479.6 ETO15181.1 - 0.12 12.0 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ETO15181.1 - 0.19 12.0 0.0 0.32 11.2 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RicinB_lectin_2 PF14200.6 ETO15182.1 - 0.0054 17.4 0.0 0.36 11.6 0.0 2.2 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like IL1 PF00340.19 ETO15182.1 - 0.13 11.9 0.0 1.3 8.7 0.0 2.1 1 1 0 2 2 2 0 Interleukin-1 / 18 HofP PF10748.9 ETO15183.1 - 0.11 12.0 0.0 0.23 11.0 0.0 1.5 1 0 0 1 1 1 0 DNA utilization proteins HofP DUF5446 PF17522.2 ETO15183.1 - 1.1 9.5 8.1 0.11 12.6 1.4 2.7 2 1 2 4 4 4 0 Family of unknown function (DUF5446) MCM_N PF14551.6 ETO15183.1 - 1.5 9.4 6.1 4.5 7.9 0.4 2.9 1 1 1 2 2 2 0 MCM N-terminal domain Vps5 PF09325.10 ETO15184.1 - 0.12 11.9 1.2 0.15 11.5 1.2 1.1 1 0 0 1 1 1 0 Vps5 C terminal like PUD1_2 PF18457.1 ETO15187.1 - 1.9e-12 47.6 3.1 7e-09 35.9 3.1 2.5 1 1 1 2 2 2 2 Up-Regulated in long-lived daf-2 Peptidase_C97 PF05903.14 ETO15187.1 - 0.001 18.9 2.0 0.0016 18.3 0.5 2.0 2 1 0 2 2 2 1 PPPDE putative peptidase domain LRAT PF04970.13 ETO15187.1 - 0.0015 18.9 0.1 0.0028 18.0 0.1 1.5 1 0 0 1 1 1 1 Lecithin retinol acyltransferase RabGAP-TBC PF00566.18 ETO15188.1 - 1.2e-38 132.9 9.9 1.2e-38 132.9 9.9 5.5 5 1 0 5 5 5 1 Rab-GTPase-TBC domain RCC1 PF00415.18 ETO15188.1 - 1.7e-38 131.0 25.8 6.2e-07 29.9 0.1 9.5 9 0 0 9 9 9 8 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO15188.1 - 6.7e-19 67.2 35.9 6.6e-07 29.0 4.4 5.8 6 0 0 6 6 6 4 Regulator of chromosome condensation (RCC1) repeat EMP24_GP25L PF01105.24 ETO15189.1 - 6.7e-33 114.2 0.1 1.3e-32 113.2 0.1 1.4 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SIKE PF05769.11 ETO15190.1 - 0.0012 18.9 3.0 0.0012 18.9 3.0 3.2 1 1 2 3 3 3 1 SIKE family CC2-LZ PF16516.5 ETO15190.1 - 0.0053 17.1 19.3 0.19 12.1 7.9 2.7 2 1 1 3 3 3 2 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator NPV_P10 PF05531.12 ETO15190.1 - 0.0094 16.4 15.8 2.3 8.8 0.6 3.5 2 1 1 3 3 3 3 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 ETO15190.1 - 0.012 15.9 25.9 0.014 15.6 14.5 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Cep57_CLD_2 PF14197.6 ETO15190.1 - 0.032 14.3 10.5 0.032 14.3 10.5 3.0 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 TRAF_BIRC3_bd PF16673.5 ETO15190.1 - 0.05 13.4 3.7 0.062 13.1 1.9 2.1 1 1 1 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain HAP1_N PF04849.13 ETO15190.1 - 0.11 11.7 23.8 0.023 13.9 8.2 2.4 1 1 1 2 2 2 0 HAP1 N-terminal conserved region DHR10 PF18595.1 ETO15190.1 - 0.22 11.6 22.0 0.53 10.3 11.6 2.6 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain bZIP_1 PF00170.21 ETO15190.1 - 0.33 11.1 14.9 0.2 11.8 1.1 3.6 3 0 0 3 3 3 0 bZIP transcription factor RraB PF06877.11 ETO15190.1 - 0.72 10.6 3.4 1.4 9.7 0.4 2.5 1 1 2 3 3 3 0 Regulator of ribonuclease activity B L31 PF09784.9 ETO15190.1 - 0.78 10.2 5.7 0.4 11.1 1.0 2.4 2 1 0 2 2 2 0 Mitochondrial ribosomal protein L31 HALZ PF02183.18 ETO15190.1 - 0.95 9.7 11.7 6.7 7.0 1.4 4.4 3 2 1 4 4 4 0 Homeobox associated leucine zipper YabA PF06156.13 ETO15190.1 - 1.3 9.7 23.0 0.24 12.0 6.7 3.6 1 1 3 4 4 4 0 Initiation control protein YabA UPF0242 PF06785.11 ETO15190.1 - 1.6 8.8 24.2 0.23 11.6 18.3 2.4 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Glycohydro_20b2 PF14845.6 ETO15190.1 - 1.6 9.4 9.2 2.1 9.0 7.2 1.9 1 1 1 2 2 2 0 beta-acetyl hexosaminidase like Csm1_N PF18504.1 ETO15190.1 - 2 8.8 20.6 0.37 11.1 6.0 4.5 3 1 2 5 5 5 0 Csm1 N-terminal domain DUF724 PF05266.14 ETO15190.1 - 2.6 7.8 18.4 0.59 9.9 8.1 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF724) DivIC PF04977.15 ETO15190.1 - 2.7 7.8 22.5 0.97 9.2 1.9 3.6 2 1 2 4 4 4 0 Septum formation initiator Ntox28 PF15605.6 ETO15190.1 - 5.2 7.3 9.9 0.47 10.7 3.6 2.3 2 1 0 2 2 2 0 Bacterial toxin 28 DUF5094 PF17015.5 ETO15190.1 - 7.8 6.6 19.4 0.15 12.2 10.5 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF5094) Myc_N PF01056.18 ETO15191.1 - 0.15 12.0 10.0 0.17 11.8 10.0 1.1 1 0 0 1 1 1 0 Myc amino-terminal region DUF2052 PF09747.9 ETO15191.1 - 0.69 10.0 14.3 0.83 9.8 14.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) FAM176 PF14851.6 ETO15191.1 - 0.84 9.3 10.4 1 9.0 10.4 1.2 1 0 0 1 1 1 0 FAM176 family DUF913 PF06025.12 ETO15191.1 - 0.97 8.3 11.0 0.94 8.4 11.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SPATIAL PF15256.6 ETO15191.1 - 1 9.7 10.6 1.1 9.5 10.6 1.1 1 0 0 1 1 1 0 SPATIAL Cnd2 PF05786.14 ETO15191.1 - 1.4 7.5 17.5 1.5 7.4 17.5 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 ORC6 PF05460.13 ETO15191.1 - 1.5 8.0 16.8 1.6 7.9 16.8 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) RR_TM4-6 PF06459.12 ETO15191.1 - 1.5 8.5 19.3 1.7 8.4 19.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 ETO15191.1 - 1.7 9.1 11.0 2.5 8.6 10.8 1.4 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking NPR3 PF03666.13 ETO15191.1 - 2 7.1 15.4 2.1 7.0 15.4 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CLN3 PF02487.17 ETO15191.1 - 2.6 7.0 8.1 2.9 6.8 8.1 1.0 1 0 0 1 1 1 0 CLN3 protein Paf1 PF03985.13 ETO15191.1 - 3.5 6.5 17.8 4.2 6.3 17.8 1.0 1 0 0 1 1 1 0 Paf1 Nucleoside_tran PF01733.18 ETO15191.1 - 4 6.7 4.8 4.6 6.5 4.8 1.1 1 0 0 1 1 1 0 Nucleoside transporter Zip PF02535.22 ETO15191.1 - 4.8 6.3 9.1 5.6 6.1 9.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO15191.1 - 5 5.8 14.3 5.7 5.6 14.3 1.0 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO15191.1 - 5.9 5.1 13.4 6.7 4.9 13.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4604 PF15377.6 ETO15191.1 - 6 7.2 25.7 7.6 6.9 25.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Vfa1 PF08432.10 ETO15191.1 - 6.5 7.1 19.9 7.8 6.8 19.9 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DAG_kinase_N PF14513.6 ETO15191.1 - 6.6 6.9 11.2 7.6 6.7 11.2 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Pannexin_like PF12534.8 ETO15191.1 - 7.1 5.6 11.3 8.7 5.3 11.3 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PA26 PF04636.13 ETO15191.1 - 9.5 5.0 11.1 11 4.8 11.1 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sec62 PF03839.16 ETO15191.1 - 9.5 5.7 15.6 11 5.4 15.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 WD40 PF00400.32 ETO15193.1 - 2.2e-57 189.7 16.7 7.1e-10 39.3 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15193.1 - 3.6e-24 84.9 4.6 1.2e-05 25.5 0.1 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15193.1 - 3.3e-14 52.6 0.6 0.03 13.3 0.0 6.1 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15193.1 - 3.7e-10 39.6 0.6 0.0032 16.8 0.0 3.5 2 1 2 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO15193.1 - 2.3e-08 33.2 5.6 0.09 11.4 0.0 4.9 1 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO15193.1 - 6.1e-05 22.8 4.0 6.9 6.7 0.0 6.2 7 1 1 8 8 8 2 WD40-like Beta Propeller Repeat Big_3_5 PF16640.5 ETO15193.1 - 0.001 19.2 0.1 0.96 9.7 0.0 3.3 4 0 0 4 4 4 1 Bacterial Ig-like domain (group 3) Proteasome_A_N PF10584.9 ETO15193.1 - 0.0085 15.8 4.5 2.2 8.0 0.1 4.6 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature MMS1_N PF10433.9 ETO15193.1 - 0.011 14.4 0.5 0.6 8.7 0.0 2.5 1 1 0 2 2 2 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF5570 PF17731.1 ETO15193.1 - 0.015 15.4 1.6 0.87 9.7 0.2 3.0 1 1 3 4 4 4 0 Family of unknown function (DUF5570) TruB_C PF09142.11 ETO15193.1 - 0.019 14.7 0.0 0.48 10.2 0.0 2.8 3 0 0 3 3 3 0 tRNA Pseudouridine synthase II, C terminal NifU_N PF01592.16 ETO15193.1 - 0.065 13.4 0.0 7.7 6.7 0.0 2.6 3 0 0 3 3 3 0 NifU-like N terminal domain IKI3 PF04762.12 ETO15193.1 - 0.085 10.8 0.0 0.3 9.0 0.0 1.7 1 1 0 1 1 1 0 IKI3 family ubiquitin PF00240.23 ETO15194.1 - 2.2e-67 222.8 4.6 2.5e-33 113.7 0.4 2.2 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETO15194.1 - 8.7e-33 112.0 4.3 2.3e-16 59.4 0.5 2.2 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO15194.1 - 9.6e-13 48.4 1.1 9.9e-05 22.7 0.1 3.3 2 2 0 2 2 2 2 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO15194.1 - 8e-09 35.3 0.6 0.0049 16.8 0.1 2.4 2 0 0 2 2 2 2 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO15194.1 - 6.3e-08 32.7 0.2 0.017 15.2 0.0 2.8 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_5 PF18037.1 ETO15194.1 - 2.3e-07 31.1 1.8 0.02 15.2 0.0 2.5 3 0 0 3 3 3 2 Ubiquitin-like domain DUF2407 PF10302.9 ETO15194.1 - 3.3e-06 27.6 0.1 0.13 12.8 0.0 2.3 1 1 1 2 2 2 2 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO15194.1 - 7.8e-05 22.7 3.9 8.3 6.5 0.2 4.3 3 1 1 4 4 4 1 Ubiquitin-like domain Sde2_N_Ubi PF13019.6 ETO15194.1 - 0.0084 15.9 0.0 2.1 8.1 0.0 2.2 2 0 0 2 2 2 2 Silencing defective 2 N-terminal ubiquitin domain PI3K_rbd PF00794.18 ETO15194.1 - 0.011 15.9 0.2 3.4 7.9 0.0 2.7 2 0 0 2 2 2 0 PI3-kinase family, ras-binding domain DUF2870 PF11069.8 ETO15194.1 - 0.027 14.9 0.2 21 5.6 0.0 3.1 2 2 2 4 4 4 0 Protein of unknown function (DUF2870) eRF1_1 PF03463.15 ETO15194.1 - 0.03 14.3 0.9 7.8 6.5 0.0 3.1 3 0 0 3 3 3 0 eRF1 domain 1 RBD PF02196.15 ETO15194.1 - 0.069 13.2 0.0 19 5.4 0.0 2.4 2 0 0 2 2 2 0 Raf-like Ras-binding domain DUF969 PF06149.12 ETO15194.1 - 0.14 11.5 0.0 21 4.5 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF969) TauE PF01925.19 ETO15195.1 - 3.8e-21 75.8 30.6 1.2e-11 44.8 16.7 2.6 2 1 0 2 2 2 2 Sulfite exporter TauE/SafE DUF3169 PF11368.8 ETO15195.1 - 0.0012 18.4 0.2 0.0012 18.4 0.2 4.6 4 1 0 4 4 4 1 Protein of unknown function (DUF3169) RNA_pol_Rpb1_4 PF05000.17 ETO15195.1 - 0.1 12.6 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 4 DUF4051 PF13260.6 ETO15195.1 - 2.9 7.7 9.1 1.4 8.7 1.6 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4051) DUF5313 PF17240.2 ETO15195.1 - 6.3 7.2 5.7 1.1 9.7 0.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5313) SLATT_3 PF18184.1 ETO15195.1 - 7.5 6.7 7.5 7.4 6.7 0.3 2.7 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 3 TraL PF07178.11 ETO15195.1 - 7.8 7.0 12.2 0.6 10.6 0.3 3.7 4 0 0 4 4 4 0 TraL protein Glyco_hydro_2 PF00703.21 ETO15196.1 - 1e-08 35.8 0.0 1.7e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2 Glyco_hydro_2_C PF02836.17 ETO15196.1 - 0.0015 17.7 0.0 0.0025 17.0 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain Ig_GlcNase PF18368.1 ETO15198.1 - 3.9e-22 78.4 0.0 5.6e-22 77.9 0.0 1.2 1 0 0 1 1 1 1 Exo-beta-D-glucosaminidase Ig-fold domain Ig_mannosidase PF17753.1 ETO15198.1 - 0.031 14.0 0.1 0.052 13.3 0.1 1.5 1 0 0 1 1 1 0 Ig-fold domain Peptidase_M15_3 PF08291.11 ETO15200.1 - 6.8e-07 29.4 0.1 3.1e-06 27.2 0.1 1.9 1 1 0 1 1 1 1 Peptidase M15 Thioredoxin_8 PF13905.6 ETO15201.1 - 0.15 12.4 5.8 0.27 11.6 5.3 1.6 1 1 0 1 1 1 0 Thioredoxin-like SWIRM-assoc_1 PF16495.5 ETO15202.1 - 0.26 11.3 2.0 0.32 11.0 0.4 1.9 1 1 1 2 2 2 0 SWIRM-associated region 1 Radical_SAM PF04055.21 ETO15203.1 - 4.2e-07 30.5 0.0 7e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Radical SAM superfamily CbiX PF01903.17 ETO15203.1 - 0.069 13.5 0.0 0.097 13.0 0.0 1.3 1 0 0 1 1 1 0 CbiX WD40 PF00400.32 ETO15205.1 - 1.4e-31 108.1 10.4 8.9e-09 35.9 0.6 7.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15205.1 - 4.5e-13 49.3 0.4 0.01 16.1 0.0 5.8 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Kelch_5 PF13854.6 ETO15205.1 - 4.4e-08 32.9 1.6 0.015 15.3 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Ge1_WD40 PF16529.5 ETO15205.1 - 1.9e-05 23.8 0.1 0.0063 15.5 0.0 3.9 2 1 3 5 5 5 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_4 PF13418.6 ETO15205.1 - 4.4e-05 23.4 0.2 0.076 13.0 0.0 3.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO15205.1 - 0.00024 21.2 2.5 0.33 11.3 0.2 3.8 5 0 0 5 5 5 2 Kelch motif Cytochrom_D1 PF02239.16 ETO15205.1 - 0.0034 16.0 0.1 1.5 7.3 0.0 3.1 2 1 0 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO15205.1 - 0.016 14.6 0.4 0.083 12.2 0.1 2.1 2 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO15205.1 - 0.032 12.9 0.0 5.7 5.4 0.1 3.1 3 0 0 3 3 3 0 Nucleoporin Nup120/160 PD40 PF07676.12 ETO15205.1 - 0.15 12.1 0.2 6.9 6.7 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Peptidase_C1 PF00112.23 ETO15206.1 - 4.3e-55 187.2 5.3 4.7e-55 187.0 5.3 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ETO15206.1 - 0.00065 18.6 0.2 0.00091 18.1 0.2 1.1 1 0 0 1 1 1 1 Peptidase C1-like family MTHFR_C PF12225.8 ETO15206.1 - 0.045 13.4 2.5 2.7 7.7 0.2 2.6 2 0 0 2 2 2 0 Methylene-tetrahydrofolate reductase C terminal DDE_Tnp_1_2 PF13586.6 ETO15208.1 - 0.028 14.8 0.1 0.046 14.1 0.1 1.3 1 0 0 1 1 1 0 Transposase DDE domain MAS20 PF02064.15 ETO15208.1 - 0.052 13.7 1.1 0.071 13.2 1.1 1.1 1 0 0 1 1 1 0 MAS20 protein import receptor Tub PF01167.18 ETO15209.1 - 6.9e-41 140.6 2.8 9.4e-41 140.1 0.2 2.0 2 0 0 2 2 2 1 Tub family PulA_N1 PF17999.1 ETO15209.1 - 0.17 12.6 1.8 2.4 9.0 0.1 3.2 3 1 0 3 3 3 0 Pullulanase N1-terminal domain zf-CCCH PF00642.24 ETO15210.1 - 1.2e-09 37.8 1.1 1.2e-09 37.8 1.1 1.7 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO15210.1 - 0.0014 18.6 3.6 0.0014 18.6 3.6 1.9 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 ETO15210.1 - 0.022 14.5 1.3 0.022 14.5 1.3 1.9 2 0 0 2 2 2 0 CCCH-type zinc finger HAND PF09110.11 ETO15210.1 - 0.035 14.9 0.2 0.072 13.9 0.1 1.6 2 0 0 2 2 2 0 HAND zf-CCCH_2 PF14608.6 ETO15210.1 - 0.049 14.1 0.5 0.049 14.1 0.5 2.2 3 0 0 3 3 3 0 RNA-binding, Nab2-type zinc finger PAD_M PF08527.10 ETO15211.1 - 0.00036 20.2 0.6 0.0095 15.6 0.0 2.2 1 1 1 2 2 2 1 Protein-arginine deiminase (PAD) middle domain CorA PF01544.18 ETO15211.1 - 0.016 14.6 2.1 0.02 14.2 2.1 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein ZNRF_3_ecto PF18212.1 ETO15211.1 - 0.05 13.6 0.2 0.11 12.5 0.1 1.6 2 0 0 2 2 2 0 ZNRF-3 Ectodomain ALMT PF11744.8 ETO15211.1 - 0.98 8.2 2.9 1 8.1 2.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 ETO15211.1 - 1.3 7.8 2.0 1.5 7.6 2.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Syndecan PF01034.20 ETO15212.1 - 0.3 11.0 4.0 9.1 6.3 0.3 2.9 2 0 0 2 2 2 0 Syndecan domain DEP PF00610.21 ETO15213.1 - 9.1e-07 28.9 2.4 1.6e-06 28.1 0.6 2.2 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DASH_Dad3 PF08656.10 ETO15213.1 - 0.036 14.1 0.4 0.14 12.3 0.1 2.2 2 0 0 2 2 2 0 DASH complex subunit Dad3 DUF4806 PF16064.5 ETO15213.1 - 1.1 9.6 3.7 16 5.8 0.1 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4806) Tristanin_u2 PF16638.5 ETO15214.1 - 0.015 16.1 12.6 0.034 15.0 12.6 1.5 1 0 0 1 1 1 0 Unstructured region on methyltransferase between zinc-fingers IstB_IS21 PF01695.17 ETO15215.1 - 0.049 13.4 0.0 0.066 12.9 0.0 1.2 1 0 0 1 1 1 0 IstB-like ATP binding protein Nckap1 PF09735.9 ETO15216.1 - 4.5e-28 97.8 2.3 5.2e-28 97.6 2.3 1.0 1 0 0 1 1 1 1 Membrane-associated apoptosis protein Nckap1 PF09735.9 ETO15217.1 - 3e-62 211.0 0.0 3.8e-46 157.7 0.0 3.3 1 1 1 2 2 2 2 Membrane-associated apoptosis protein U-box PF04564.15 ETO15218.1 - 5.9e-12 45.6 0.1 1.7e-11 44.1 0.1 1.7 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO15218.1 - 0.019 15.1 0.0 0.032 14.3 0.0 1.3 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETO15218.1 - 0.12 12.2 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit Kelch_1 PF01344.25 ETO15220.1 - 1.6e-05 24.4 0.3 0.0061 16.1 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO15220.1 - 9.1e-05 22.6 0.9 0.25 11.7 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO15220.1 - 0.028 14.4 0.0 1.5 8.9 0.0 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO15220.1 - 0.051 13.6 0.0 0.051 13.6 0.0 2.7 4 0 0 4 4 4 0 Kelch motif NFRKB_winged PF14465.6 ETO15220.1 - 0.062 13.5 2.7 0.21 11.8 0.4 2.7 2 0 0 2 2 2 0 NFRKB Winged Helix-like WD40 PF00400.32 ETO15221.1 - 2.1e-39 132.8 9.9 5.4e-10 39.7 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15221.1 - 3.3e-12 46.5 6.2 0.00032 20.9 0.1 5.8 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15221.1 - 6.8e-12 45.0 0.3 0.0032 16.5 0.0 5.0 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15221.1 - 7.6e-11 41.9 3.5 0.00015 21.2 0.2 3.6 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO15221.1 - 2.8e-10 39.5 5.8 0.017 13.8 0.1 5.6 1 1 5 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO15221.1 - 3.8e-08 33.4 2.0 0.001 19.0 0.1 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Str_synth PF03088.16 ETO15221.1 - 1.8e-05 24.8 1.9 3.1 8.0 0.0 5.3 2 1 3 5 5 5 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO15221.1 - 6.8e-05 21.6 1.5 0.041 12.4 0.1 2.8 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO15221.1 - 0.00013 20.9 5.4 0.54 8.9 0.0 3.9 1 1 2 3 3 3 3 Nup133 N terminal like PD40 PF07676.12 ETO15221.1 - 0.003 17.4 0.8 8 6.5 0.0 3.9 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DRIM PF07539.12 ETO15222.1 - 0.004 15.5 0.2 0.0041 15.5 0.2 1.0 1 0 0 1 1 1 1 Down-regulated in metastasis PigN PF04987.14 ETO15222.1 - 1.5 7.6 4.3 0.33 9.8 0.5 1.6 2 0 0 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) Pkinase PF00069.25 ETO15224.1 - 7.3e-24 84.5 0.3 1.3e-23 83.7 0.3 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15224.1 - 0.014 14.7 0.0 0.026 13.8 0.0 1.4 1 1 0 1 1 1 0 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO15224.1 - 0.02 13.7 0.0 0.028 13.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase APH PF01636.23 ETO15224.1 - 0.037 13.9 0.0 0.061 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase PF00069.25 ETO15225.1 - 0.039 13.3 0.0 0.082 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain FTA2 PF13095.6 ETO15225.1 - 0.096 12.3 0.1 0.31 10.6 0.0 1.7 2 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EF-hand_7 PF13499.6 ETO15226.1 - 0.0035 17.8 2.5 2.5 8.6 0.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO15226.1 - 0.027 14.4 6.6 0.18 11.8 0.0 3.0 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 ETO15226.1 - 0.074 12.9 4.5 0.11 12.4 2.0 2.6 2 1 1 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.32 ETO15226.1 - 0.52 10.0 6.6 5.1 6.9 2.6 3.2 3 0 0 3 3 3 0 EF hand Kelch_6 PF13964.6 ETO15227.1 - 0.0016 18.6 0.4 0.3 11.5 0.5 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO15227.1 - 0.002 18.0 0.1 0.54 10.3 0.3 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO15227.1 - 0.0094 15.9 0.1 2.9 8.0 0.0 2.5 2 0 0 2 2 2 2 Kelch motif APG6 PF04111.12 ETO15229.1 - 0.0069 16.4 1.6 0.0089 16.0 1.5 1.3 1 1 0 1 1 1 1 Apg6 BARA domain MMS19_C PF12460.8 ETO15229.1 - 0.019 14.1 2.1 0.023 13.8 2.1 1.2 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal Arg_decarb_HB PF17810.1 ETO15229.1 - 0.028 14.7 0.3 0.61 10.4 0.0 2.7 2 1 1 3 3 3 0 Arginine decarboxylase helical bundle domain AAA_lid_7 PF17867.1 ETO15229.1 - 0.068 13.4 0.2 0.56 10.4 0.1 2.1 1 1 1 2 2 2 0 Midasin AAA lid domain ENTH PF01417.20 ETO15229.1 - 0.097 12.7 5.6 0.86 9.7 2.9 2.8 1 1 1 2 2 2 0 ENTH domain UPF0223 PF05256.12 ETO15229.1 - 0.16 12.4 1.4 4.9 7.6 0.1 2.8 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0223) DUF3887 PF13026.6 ETO15229.1 - 0.22 12.4 0.2 0.22 12.4 0.2 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3887) DUF3800 PF12686.7 ETO15229.1 - 1.1 9.9 5.6 3.6 8.2 5.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) DUF1837 PF08878.11 ETO15229.1 - 7.3 6.3 17.1 1.6 8.5 1.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF1837) GPR_Gpa2_C PF11970.8 ETO15230.1 - 0.033 14.3 1.3 0.056 13.5 0.3 1.9 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term Kelch_2 PF07646.15 ETO15231.1 - 1.7e-07 31.0 0.1 0.00013 21.8 0.1 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO15231.1 - 5.9e-07 29.4 0.1 0.0031 17.5 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO15231.1 - 4.5e-06 26.2 0.1 2.4e-05 23.8 0.1 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO15231.1 - 0.00022 21.4 0.0 0.00068 19.9 0.0 1.8 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15231.1 - 0.011 15.8 0.1 0.054 13.5 0.1 2.1 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO15231.1 - 0.019 15.2 0.1 3.2 8.2 0.1 2.6 2 0 0 2 2 2 0 Kelch motif HSDR_N_2 PF13588.6 ETO15232.1 - 0.015 15.2 0.7 0.024 14.6 0.7 1.3 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) DUF2951 PF11166.8 ETO15234.1 - 0.0015 18.7 2.1 0.0027 17.9 2.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2951) DUF908 PF06012.12 ETO15234.1 - 0.012 15.0 0.5 0.022 14.2 0.3 1.4 1 1 1 2 2 2 0 Domain of Unknown Function (DUF908) HEAT PF02985.22 ETO15235.1 - 5e-19 66.8 2.6 0.098 13.0 0.0 8.3 8 0 0 8 8 7 5 HEAT repeat HEAT_2 PF13646.6 ETO15235.1 - 3.1e-15 56.3 0.0 0.00028 21.2 0.0 5.6 4 2 2 6 6 5 3 HEAT repeats RTP1_C1 PF10363.9 ETO15235.1 - 3.1e-12 46.7 5.5 0.057 13.6 0.1 6.8 2 1 2 5 5 5 3 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETO15235.1 - 4.6e-09 36.5 34.0 0.0031 17.6 0.8 7.2 1 1 7 8 8 8 5 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO15235.1 - 2e-08 34.5 0.0 0.049 14.2 0.0 6.5 7 1 1 8 8 8 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO15235.1 - 2.6e-05 24.7 14.0 2 9.0 0.8 6.7 3 2 3 7 7 7 3 Vacuolar 14 Fab1-binding region MMS19_N PF14500.6 ETO15235.1 - 0.00043 20.0 4.9 0.011 15.3 0.0 4.6 1 1 3 5 5 5 1 Dos2-interacting transcription regulator of RNA-Pol-II Spore_III_AB PF09548.10 ETO15235.1 - 0.00064 19.9 1.1 0.00064 19.9 1.1 4.6 3 2 1 5 5 5 1 Stage III sporulation protein AB (spore_III_AB) TIP120 PF08623.10 ETO15235.1 - 0.007 16.1 12.4 4.2 7.1 0.2 5.3 3 2 2 5 5 5 2 TATA-binding protein interacting (TIP20) SAC3_GANP PF03399.16 ETO15235.1 - 0.048 13.0 16.5 0.27 10.6 0.1 5.1 3 2 0 5 5 5 0 SAC3/GANP family RBB1NT PF08169.11 ETO15235.1 - 0.097 12.8 0.1 12 6.1 0.0 3.5 3 0 0 3 3 3 0 RBB1NT (NUC162) domain HNOB PF07700.15 ETO15235.1 - 0.12 12.4 2.2 7.1 6.6 0.1 3.1 2 0 0 2 2 2 0 Haem-NO-binding DUF1421 PF07223.11 ETO15235.1 - 0.18 11.7 0.1 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 UBA-like domain (DUF1421) XkdW PF09636.10 ETO15235.1 - 0.23 11.6 2.2 1 9.5 0.0 3.4 4 0 0 4 4 4 0 XkdW protein Activator-TraM PF11657.8 ETO15235.1 - 0.27 11.0 3.1 0.62 9.9 0.0 2.9 3 0 0 3 3 3 0 Transcriptional activator TraM DUF3349 PF11829.8 ETO15235.1 - 0.56 11.0 4.6 29 5.5 0.0 5.1 6 0 0 6 6 5 0 Protein of unknown function (DUF3349) CH PF00307.31 ETO15237.1 - 4.4e-21 75.1 0.1 3.7e-09 36.7 0.0 2.9 3 0 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO15237.1 - 0.021 14.6 0.0 0.058 13.2 0.0 1.7 1 0 0 1 1 1 0 CAMSAP CH domain Cys_rich_VLP PF14194.6 ETO15238.1 - 0.057 13.6 0.4 0.1 12.7 0.4 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP Kelch_4 PF13418.6 ETO15239.1 - 8.2e-05 22.5 0.6 0.0026 17.8 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO15239.1 - 0.00013 21.5 0.5 0.011 15.3 0.5 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO15239.1 - 0.00048 20.0 2.9 0.62 10.1 0.3 3.8 3 1 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO15239.1 - 0.025 14.9 1.2 11 6.5 0.0 3.7 2 1 1 3 3 3 0 Kelch motif WD40 PF00400.32 ETO15240.1 - 4.1e-38 128.7 24.3 2.2e-07 31.4 0.8 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO15240.1 - 1.7e-10 40.2 6.2 0.0081 14.9 0.1 5.9 2 2 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15240.1 - 4.5e-10 39.7 0.2 0.011 16.0 0.0 4.6 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15240.1 - 1.1e-05 25.0 9.7 0.032 13.6 0.2 4.3 4 1 0 4 4 4 2 WD40-like domain zf-TRAF PF02176.18 ETO15240.1 - 0.0038 17.9 6.2 0.0038 17.9 6.2 2.1 2 0 0 2 2 1 1 TRAF-type zinc finger Jnk-SapK_ap_N PF09744.9 ETO15240.1 - 0.022 15.0 9.0 0.039 14.2 9.0 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PspA_IM30 PF04012.12 ETO15240.1 - 0.034 13.7 3.3 0.051 13.2 3.3 1.2 1 0 0 1 1 1 0 PspA/IM30 family FapA PF03961.13 ETO15240.1 - 0.093 11.3 9.3 0.14 10.8 9.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Lectin_N PF03954.14 ETO15240.1 - 0.14 11.9 7.4 0.077 12.7 3.5 2.3 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Laminin_II PF06009.12 ETO15240.1 - 0.18 11.8 7.8 0.33 11.0 7.8 1.3 1 0 0 1 1 1 0 Laminin Domain II bZIP_1 PF00170.21 ETO15240.1 - 0.25 11.5 11.8 0.62 10.2 5.7 2.7 1 1 1 2 2 2 0 bZIP transcription factor Cep57_CLD_2 PF14197.6 ETO15240.1 - 0.34 11.0 5.4 8.4 6.6 0.7 2.6 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 Exonuc_VII_L PF02601.15 ETO15240.1 - 0.36 10.3 5.0 0.53 9.8 5.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit E2R135 PF11570.8 ETO15240.1 - 0.41 11.0 5.0 0.89 9.8 5.0 1.5 1 0 0 1 1 1 0 Coiled-coil receptor-binding R-domain of colicin E2 DUF840 PF05801.11 ETO15240.1 - 0.62 10.2 3.1 5.1 7.2 0.0 3.2 4 0 0 4 4 4 0 Lagovirus protein of unknown function (DUF840) TSC22 PF01166.18 ETO15240.1 - 0.91 9.9 9.7 0.6 10.5 4.7 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family YabA PF06156.13 ETO15240.1 - 1 10.0 17.5 0.46 11.1 10.2 2.8 2 1 1 3 3 2 0 Initiation control protein YabA bZIP_2 PF07716.15 ETO15240.1 - 2.5 8.2 8.9 0.26 11.4 3.5 2.1 2 0 0 2 2 2 0 Basic region leucine zipper DUF1664 PF07889.12 ETO15240.1 - 3.9 7.5 6.7 9.1 6.3 6.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Ax_dynein_light PF10211.9 ETO15240.1 - 4.8 7.1 19.3 5.8 6.8 10.8 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain Myb_DNA-bind_3 PF12776.7 ETO15240.1 - 6.9 7.7 10.5 1.7 9.7 4.5 2.8 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain DivIC PF04977.15 ETO15240.1 - 7.8 6.3 11.4 5.8 6.8 6.8 2.4 1 1 1 2 2 2 0 Septum formation initiator WD40 PF00400.32 ETO15243.1 - 2.9e-13 50.0 9.1 7.1e-06 26.7 0.8 3.8 3 2 0 3 3 3 2 WD domain, G-beta repeat Ig_6 PF18452.1 ETO15243.1 - 0.052 13.1 0.3 0.097 12.3 0.3 1.4 1 0 0 1 1 1 0 Immunoglobulin domain BBS2_Mid PF14783.6 ETO15243.1 - 0.057 13.5 0.2 0.1 12.6 0.2 1.7 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region PID_2 PF14719.6 ETO15244.1 - 0.07 13.0 0.8 0.12 12.3 0.8 1.3 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) FA_desaturase PF00487.24 ETO15245.1 - 1.7e-24 87.1 17.4 4.3e-24 85.7 17.4 1.5 1 1 0 1 1 1 1 Fatty acid desaturase DUF4507 PF14964.6 ETO15248.1 - 0.018 14.0 0.4 1.7 7.5 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4507) CAP_GLY PF01302.25 ETO15249.1 - 5.4e-09 35.9 1.0 1.2e-08 34.8 1.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain Kelch_6 PF13964.6 ETO15252.1 - 2.9e-09 36.9 8.4 0.00013 22.1 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO15252.1 - 1.6e-07 31.0 5.9 0.00078 19.3 0.1 4.7 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO15252.1 - 1.9e-05 24.1 11.7 2.9e-05 23.5 0.6 3.8 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO15252.1 - 0.00077 19.4 0.1 0.52 10.4 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO15252.1 - 0.01 16.1 0.0 0.78 10.1 0.0 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain TrmK PF04816.12 ETO15253.1 - 0.075 12.6 0.5 2 7.9 0.0 2.3 2 0 0 2 2 2 0 tRNA (adenine(22)-N(1))-methyltransferase SDA1 PF05285.12 ETO15254.1 - 0.0072 15.8 5.7 0.0072 15.8 5.7 1.6 2 0 0 2 2 2 1 SDA1 Mito_fiss_reg PF05308.11 ETO15254.1 - 0.011 15.9 5.2 0.011 15.9 5.2 1.9 2 0 0 2 2 2 0 Mitochondrial fission regulator CelTOS PF18659.1 ETO15254.1 - 0.041 14.3 0.4 0.089 13.2 0.4 1.5 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites SMN PF06003.12 ETO15254.1 - 1.6 7.9 8.0 3.1 7.0 8.0 1.5 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) zf-TRAF PF02176.18 ETO15258.1 - 7.6e-08 32.9 0.6 7.6e-08 32.9 0.6 2.3 1 1 1 2 2 2 1 TRAF-type zinc finger Microcin PF03526.13 ETO15258.1 - 0.0082 15.9 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 Colicin E1 (microcin) immunity protein zf-TRAF_2 PF15965.5 ETO15258.1 - 0.037 14.5 1.0 0.037 14.5 1.0 1.9 1 1 0 1 1 1 0 TRAF-like zinc-finger zf-CCHC PF00098.23 ETO15258.1 - 4.8 7.4 9.1 1.2 9.3 0.2 3.9 4 0 0 4 4 4 0 Zinc knuckle SRP40_C PF05022.12 ETO15259.1 - 2.8e-18 66.5 12.1 2.8e-18 66.5 12.1 3.8 4 2 1 5 5 5 1 SRP40, C-terminal domain Glyco_hydro_47 PF01532.20 ETO15260.1 - 8.2e-43 146.9 0.1 9.8e-43 146.7 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 NST1 PF13945.6 ETO15261.1 - 7.5 6.6 31.2 2.7 8.1 20.2 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator WD40 PF00400.32 ETO15263.1 - 6.9e-22 77.3 22.7 1.4e-07 32.1 3.3 6.0 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15263.1 - 1.6e-06 28.3 0.5 0.73 10.2 0.0 4.0 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15263.1 - 0.0078 14.9 0.2 13 4.2 0.0 3.5 3 1 1 4 4 4 2 Nucleoporin Nup120/160 HARP PF07443.13 ETO15263.1 - 0.038 13.6 0.0 4.1 7.1 0.0 3.1 3 0 0 3 3 3 0 HepA-related protein (HARP) ARID PF01388.21 ETO15264.1 - 0.12 13.1 0.3 0.65 10.7 0.0 2.3 3 0 0 3 3 3 0 ARID/BRIGHT DNA binding domain zf-TRAF PF02176.18 ETO15265.1 - 1.3e-07 32.2 2.3 7e-07 29.8 2.3 2.3 1 0 0 1 1 1 1 TRAF-type zinc finger Lipase_chap PF03280.14 ETO15265.1 - 0.0035 17.3 1.0 0.0035 17.3 1.0 1.9 2 0 0 2 2 2 1 Proteobacterial lipase chaperone protein DDHD PF02862.17 ETO15265.1 - 0.074 13.2 7.2 0.14 12.3 7.2 1.4 1 0 0 1 1 1 0 DDHD domain DUF3484 PF11983.8 ETO15265.1 - 7.1 7.8 7.9 1.7 9.8 3.6 2.1 2 0 0 2 2 2 0 Membrane-attachment and polymerisation-promoting switch Beach PF02138.18 ETO15266.1 - 3.4e-113 377.6 0.4 5.4e-113 377.0 0.4 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO15266.1 - 1.7e-12 47.3 0.8 1.7e-12 47.3 0.8 2.2 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ETO15266.1 - 4.7e-06 27.2 2.1 0.0044 17.8 0.0 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15266.1 - 0.0037 17.5 0.3 19 5.7 0.0 4.1 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain eIF-3c_N PF05470.12 ETO15266.1 - 2.8 6.1 8.9 4.3 5.5 8.9 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SDA1 PF05285.12 ETO15267.1 - 0.00059 19.4 11.2 0.00062 19.3 11.2 1.1 1 0 0 1 1 1 1 SDA1 Pal1 PF08316.11 ETO15267.1 - 0.031 15.0 0.7 0.051 14.3 0.7 1.4 1 0 0 1 1 1 0 Pal1 cell morphology protein Ribosomal_60s PF00428.19 ETO15267.1 - 0.031 14.8 2.4 0.031 14.8 2.4 2.4 2 0 0 2 2 1 0 60s Acidic ribosomal protein MDM1 PF15501.6 ETO15267.1 - 0.038 13.1 10.5 0.044 12.9 10.5 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Nop14 PF04147.12 ETO15267.1 - 0.089 11.0 15.3 0.11 10.7 15.3 1.1 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 ETO15267.1 - 0.1 12.4 10.8 0.12 12.1 10.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO15267.1 - 0.1 11.8 0.6 0.12 11.6 0.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2457 PF10446.9 ETO15267.1 - 0.12 11.4 18.1 0.16 11.1 18.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO15267.1 - 0.15 10.3 12.9 0.18 10.1 12.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO15267.1 - 0.2 10.4 5.2 0.27 10.0 5.2 1.3 1 0 0 1 1 1 0 Presenilin PGA2 PF07543.12 ETO15267.1 - 0.25 11.3 15.7 0.4 10.7 15.7 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 DUF913 PF06025.12 ETO15267.1 - 0.27 10.1 2.9 0.34 9.8 2.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3292 PF11696.8 ETO15267.1 - 0.29 9.4 6.7 0.38 9.1 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) TFIIF_alpha PF05793.12 ETO15267.1 - 0.3 9.6 22.6 0.38 9.3 22.6 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNA_pol_Rpc4 PF05132.14 ETO15267.1 - 0.46 10.9 5.6 0.68 10.4 5.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Peptidase_C37 PF05416.12 ETO15267.1 - 0.97 7.9 5.4 1.1 7.7 5.4 1.1 1 0 0 1 1 1 0 Southampton virus-type processing peptidase NPR3 PF03666.13 ETO15267.1 - 1.3 7.7 8.7 1.6 7.5 8.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 TRAP_alpha PF03896.16 ETO15267.1 - 1.6 7.9 8.5 2.5 7.2 8.5 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PPL5 PF18168.1 ETO15267.1 - 3 7.1 6.8 4.2 6.6 6.8 1.3 1 0 0 1 1 1 0 Prim-pol family 5 RRN3 PF05327.11 ETO15267.1 - 3.6 6.0 7.9 4.5 5.7 7.9 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PTPRCAP PF15713.5 ETO15267.1 - 5.2 7.4 21.4 7.8 6.8 21.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated WD40 PF00400.32 ETO15268.1 - 3.1e-36 122.7 21.9 8.7e-10 39.1 0.4 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15268.1 - 3.1e-14 53.0 2.0 0.00066 19.9 0.0 4.9 1 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO15268.1 - 3.6e-07 30.2 0.0 0.00045 20.2 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO15268.1 - 0.00041 19.4 0.1 0.82 8.6 0.0 3.2 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO15268.1 - 0.036 12.6 0.0 0.24 9.9 0.0 2.1 1 1 2 3 3 3 0 Cytochrome D1 heme domain WD40_like PF17005.5 ETO15268.1 - 0.044 13.1 0.0 0.86 8.9 0.0 2.7 2 1 2 4 4 4 0 WD40-like domain Frtz PF11768.8 ETO15268.1 - 0.098 10.9 0.0 1.6 7.0 0.0 2.0 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Pro_isomerase PF00160.21 ETO15269.1 - 1.4e-30 106.7 0.0 1.4e-30 106.7 0.0 2.8 2 1 0 2 2 2 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD PUF PF00806.19 ETO15270.1 - 7.4e-21 72.6 7.0 1.4e-06 27.6 0.1 4.3 4 0 0 4 4 4 4 Pumilio-family RNA binding repeat CPL PF08144.11 ETO15270.1 - 0.053 13.9 0.3 0.62 10.4 0.1 2.5 1 1 1 2 2 2 0 CPL (NUC119) domain SapB_2 PF03489.17 ETO15270.1 - 0.41 10.8 3.0 29 4.9 0.2 3.3 2 1 1 3 3 3 0 Saposin-like type B, region 2 FDX-ACB PF03147.14 ETO15271.1 - 0.0052 17.2 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain MKRN1_C PF15815.5 ETO15272.1 - 2.6 8.5 10.5 2.2 8.8 4.9 2.6 1 1 0 2 2 2 0 E3 ubiquitin-protein ligase makorin-1, C-terminal Pkinase PF00069.25 ETO15273.1 - 4.6e-08 32.7 2.7 5e-08 32.6 2.4 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15273.1 - 0.0062 15.8 1.1 0.0074 15.6 1.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase LPD5 PF18799.1 ETO15273.1 - 0.39 11.1 3.9 0.16 12.4 1.6 1.5 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 5 DHC_N1 PF08385.12 ETO15274.1 - 0.0009 18.0 0.3 0.0015 17.3 0.3 1.4 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 DUF45 PF01863.17 ETO15274.1 - 0.0015 18.6 0.2 0.002 18.2 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function DUF45 RPAP3_C PF13877.6 ETO15274.1 - 0.035 14.6 0.2 0.062 13.8 0.2 1.4 1 0 0 1 1 1 0 Potential Monad-binding region of RPAP3 DHC_N1 PF08385.12 ETO15275.1 - 6.9e-09 34.9 9.9 7.1e-09 34.9 2.0 2.0 1 1 1 2 2 2 2 Dynein heavy chain, N-terminal region 1 SLATT_6 PF18169.1 ETO15275.1 - 0.013 15.1 1.0 0.068 12.8 0.2 2.2 1 1 1 2 2 2 0 SMODS and SLOG-associating 2TM effector domain 6 Dynactin_p22 PF07426.11 ETO15275.1 - 0.014 15.3 2.6 0.032 14.1 1.3 2.1 1 1 0 1 1 1 0 Dynactin subunit p22 IBB PF01749.20 ETO15275.1 - 0.041 14.3 0.4 0.09 13.2 0.4 1.6 1 0 0 1 1 1 0 Importin beta binding domain Mur_ligase PF01225.25 ETO15275.1 - 0.12 12.7 0.0 0.26 11.6 0.0 1.7 1 0 0 1 1 1 0 Mur ligase family, catalytic domain DUF745 PF05335.13 ETO15275.1 - 1.9 8.2 4.8 0.57 9.9 1.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF745) YueH PF14166.6 ETO15276.1 - 0.092 12.6 0.0 0.25 11.2 0.0 1.7 1 0 0 1 1 1 0 YueH-like protein Se-cys_synth_N PF12390.8 ETO15276.1 - 0.16 12.2 0.0 0.31 11.3 0.0 1.4 1 0 0 1 1 1 0 Selenocysteine synthase N terminal Annexin PF00191.20 ETO15277.1 - 0.063 13.3 1.9 9.5 6.4 0.1 3.5 3 1 0 3 3 3 0 Annexin Jnk-SapK_ap_N PF09744.9 ETO15277.1 - 1.5 9.0 9.8 0.5 10.6 2.9 2.7 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF2098 PF09871.9 ETO15277.1 - 3.9 7.9 5.8 0.89 9.9 0.3 2.6 2 1 1 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2098) DUF1294 PF06961.13 ETO15278.1 - 0.044 14.0 0.0 0.098 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1294) Ion_trans PF00520.31 ETO15279.1 - 8.8e-14 51.3 13.0 1.2e-13 50.9 12.4 1.5 1 1 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ETO15280.1 - 5.9e-06 26.2 7.7 1.1e-05 25.2 7.7 1.4 1 0 0 1 1 1 1 Ion channel cNMP_binding PF00027.29 ETO15280.1 - 1.4e-05 25.1 0.0 2.7e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain RepB PF07506.11 ETO15280.1 - 0.0024 18.0 2.6 0.0024 18.0 2.6 1.5 2 0 0 2 2 2 1 RepB plasmid partitioning protein DegQ PF08181.11 ETO15280.1 - 0.015 15.4 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 DegQ (SacQ) family Consortin_C PF15281.6 ETO15280.1 - 0.12 12.4 0.4 1.4 8.9 0.1 2.6 2 0 0 2 2 2 0 Consortin C-terminus Ribosomal_S10 PF00338.22 ETO15280.1 - 1.1 9.6 4.3 11 6.4 0.4 2.4 1 1 1 2 2 2 0 Ribosomal protein S10p/S20e Transposase_31 PF04754.12 ETO15282.1 - 5.4e-32 111.1 0.1 6.1e-32 110.9 0.1 1.0 1 0 0 1 1 1 1 Putative transposase, YhgA-like Guanylate_cyc PF00211.20 ETO15283.1 - 4.8e-10 39.3 0.2 7.9e-10 38.6 0.2 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain sCache_3_3 PF17202.4 ETO15283.1 - 0.0064 16.9 0.0 0.014 15.8 0.0 1.5 1 0 0 1 1 1 1 Single cache domain 3 BofA PF07441.11 ETO15283.1 - 9.4 6.5 9.4 0.22 11.8 1.1 2.3 2 1 0 2 2 2 0 SigmaK-factor processing regulatory protein BofA DUF3046 PF11248.8 ETO15286.1 - 0.0065 16.8 0.2 0.025 14.9 0.1 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF3046) AlcCBM31 PF11606.8 ETO15286.1 - 0.018 15.2 0.1 0.025 14.8 0.1 1.3 1 0 0 1 1 1 0 Family 31 carbohydrate binding protein EBA-175_VI PF11556.8 ETO15286.1 - 0.095 13.0 3.0 0.17 12.2 3.0 1.5 1 1 0 1 1 1 0 Erythrocyte binding antigen 175 WD40 PF00400.32 ETO15287.1 - 2.1e-19 69.5 17.2 3.3e-05 24.6 0.1 5.7 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO15287.1 - 4.7e-06 25.5 1.9 0.041 12.5 1.1 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15287.1 - 0.00031 21.0 0.1 2.4 8.5 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO15289.1 - 1.7e-07 31.3 0.3 0.027 14.7 0.2 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO15289.1 - 6.8e-07 28.8 0.2 1.6e-05 24.4 0.2 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO15289.1 - 2.1e-06 27.6 0.0 0.0095 15.9 0.0 2.2 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO15289.1 - 0.0039 17.1 1.5 0.89 9.6 1.4 2.7 2 1 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO15289.1 - 0.032 14.2 0.3 0.66 10.0 1.2 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO15291.1 - 0.00048 20.0 1.1 16 5.6 0.0 4.4 4 0 0 4 4 4 2 Kelch motif DUF2272 PF10030.9 ETO15291.1 - 0.0019 18.0 0.0 0.12 12.1 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_4 PF13418.6 ETO15291.1 - 0.035 14.1 0.1 0.62 10.1 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO15291.1 - 0.049 13.2 0.3 8.9 6.0 0.0 3.7 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO15292.1 - 2.5e-26 91.4 6.8 3.2e-07 30.9 1.6 6.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15292.1 - 3.2e-10 40.2 5.1 0.096 13.0 0.1 6.7 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15292.1 - 1.1e-08 34.4 0.1 0.0049 15.9 0.0 4.2 2 2 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein zf-TRAF PF02176.18 ETO15292.1 - 1.1e-06 29.2 4.7 3.9e-06 27.5 4.7 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger PD40 PF07676.12 ETO15292.1 - 0.0014 18.5 0.6 0.32 11.0 0.0 4.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_6 PF13964.6 ETO15292.1 - 0.057 13.7 3.8 6.5 7.2 0.1 4.0 4 0 0 4 4 4 0 Kelch motif Peroxin-13_N PF04088.13 ETO15292.1 - 0.13 12.5 0.1 0.5 10.6 0.1 2.0 1 1 0 1 1 1 0 Peroxin 13, N-terminal region TFIIIC_delta PF12657.7 ETO15292.1 - 2.4 8.1 6.2 0.4 10.6 0.1 2.9 3 0 0 3 3 3 0 Transcription factor IIIC subunit delta N-term IF-2 PF11987.8 ETO15293.1 - 1.7e-16 60.2 0.0 3e-16 59.4 0.0 1.4 1 0 0 1 1 1 1 Translation-initiation factor 2 Peptidase_S49_N PF08496.10 ETO15293.1 - 0.0077 16.3 2.4 0.015 15.4 2.4 1.4 1 0 0 1 1 1 1 Peptidase family S49 N-terminal GTP_EFTU_D2 PF03144.25 ETO15293.1 - 0.074 13.4 0.0 0.19 12.2 0.0 1.8 1 1 0 1 1 1 0 Elongation factor Tu domain 2 DUF4887 PF16228.5 ETO15293.1 - 0.22 11.7 6.7 0.33 11.1 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4887) GTP_EFTU PF00009.27 ETO15294.1 - 5e-26 91.4 0.6 4e-19 68.9 0.2 3.4 2 1 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO15294.1 - 1.6e-06 28.2 0.0 3.3e-06 27.2 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase ATP_bind_1 PF03029.17 ETO15294.1 - 0.00013 21.9 0.0 0.00097 19.0 0.0 2.2 1 1 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_23 PF13476.6 ETO15294.1 - 0.002 18.6 4.1 7 7.1 0.0 2.5 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ETO15294.1 - 0.12 12.3 0.0 8.2 6.3 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase PRIMA1 PF16101.5 ETO15294.1 - 0.36 10.9 3.7 0.86 9.6 3.7 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Dynamin_N PF00350.23 ETO15294.1 - 2.4 8.2 6.7 6.9 6.7 0.0 3.5 2 2 1 3 3 3 0 Dynamin family RNA_Me_trans PF04252.13 ETO15296.1 - 0.02 14.5 0.2 0.033 13.8 0.2 1.3 1 0 0 1 1 1 0 Predicted SAM-dependent RNA methyltransferase RGS PF00615.19 ETO15298.1 - 0.11 12.8 0.3 0.27 11.5 0.1 1.8 2 0 0 2 2 2 0 Regulator of G protein signaling domain DUF4798 PF16055.5 ETO15299.1 - 0.16 12.2 0.1 0.58 10.4 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4798) PNTB PF02233.16 ETO15300.1 - 1.9e-183 610.6 24.8 2.5e-182 606.9 19.4 2.1 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 ETO15300.1 - 1.8e-75 252.9 0.1 3.8e-75 251.8 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 ETO15300.1 - 2.6e-43 147.6 0.0 4.8e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 ETO15300.1 - 4.2e-31 107.3 2.6 4.2e-31 107.3 2.6 3.6 3 1 1 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 ETO15300.1 - 0.0018 17.7 0.2 0.48 9.8 0.0 3.4 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ETO15300.1 - 0.044 13.0 0.8 0.087 12.0 0.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase TMEM215 PF15746.5 ETO15301.1 - 0.066 12.7 0.1 0.076 12.5 0.1 1.1 1 0 0 1 1 1 0 TMEM215 family PPR_3 PF13812.6 ETO15301.1 - 0.084 13.0 0.0 0.2 11.7 0.0 1.7 1 0 0 1 1 1 0 Pentatricopeptide repeat domain BBL5 PF07289.11 ETO15303.1 - 9.4e-49 166.2 1.7 9.4e-49 166.2 1.7 2.7 2 1 0 2 2 2 1 Bardet-Biedl syndrome 5 protein bPH_3 PF14470.6 ETO15303.1 - 5.5e-06 26.6 2.1 0.00026 21.3 0.0 3.4 2 0 0 2 2 2 1 Bacterial PH domain Ank_2 PF12796.7 ETO15304.1 - 2.6e-23 82.4 2.7 2.8e-13 50.3 0.1 2.5 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO15304.1 - 3.8e-14 52.8 0.3 2.4e-09 37.5 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO15304.1 - 7.2e-10 38.3 0.1 0.013 16.0 0.0 3.8 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO15304.1 - 7.5e-10 38.9 0.2 0.00035 20.8 0.0 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO15304.1 - 8.4e-08 32.3 0.1 0.024 15.1 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat SspH PF08141.12 ETO15304.1 - 0.61 10.3 3.0 1.4 9.1 0.2 3.0 4 0 0 4 4 4 0 Small acid-soluble spore protein H family DFP PF04127.15 ETO15305.1 - 0.00082 19.3 0.0 0.00096 19.0 0.0 1.2 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein DUF903 PF06004.12 ETO15305.1 - 0.11 12.4 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) QIL1 PF15884.5 ETO15305.1 - 0.14 12.7 0.1 0.32 11.6 0.1 1.6 1 1 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 PsbK PF02533.15 ETO15306.1 - 0.053 13.7 0.4 0.089 13.0 0.4 1.4 1 0 0 1 1 1 0 Photosystem II 4 kDa reaction centre component WD40 PF00400.32 ETO15307.1 - 0.00026 21.7 4.5 0.0017 19.2 0.3 3.7 3 1 1 4 4 4 1 WD domain, G-beta repeat Mucin PF01456.17 ETO15307.1 - 0.21 11.5 12.3 0.41 10.6 12.3 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Orf78 PF06024.12 ETO15307.1 - 0.38 11.1 8.9 0.44 10.9 4.1 2.4 2 1 0 2 2 2 0 Orf78 (ac78) G-alpha PF00503.20 ETO15308.1 - 7.3e-05 22.1 0.1 8.6e-05 21.9 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Pox_E10 PF04805.12 ETO15308.1 - 0.19 11.6 1.4 2.4 8.1 0.0 2.7 1 1 2 3 3 3 0 E10-like protein conserved region WD40 PF00400.32 ETO15310.1 - 1.4e-06 28.9 14.8 0.0016 19.2 2.8 3.7 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO15310.1 - 0.032 12.9 1.7 0.17 10.5 0.3 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO15310.1 - 0.06 12.1 0.1 0.071 11.8 0.1 1.3 1 0 0 1 1 1 0 Nup133 N terminal like BUD22 PF09073.10 ETO15311.1 - 0.0031 16.9 25.7 0.0044 16.4 25.7 1.2 1 0 0 1 1 1 1 BUD22 Mem_trans PF03547.18 ETO15311.1 - 0.0099 14.3 0.0 0.015 13.7 0.0 1.3 1 0 0 1 1 1 1 Membrane transport protein Sec62 PF03839.16 ETO15311.1 - 0.097 12.2 11.9 2.7 7.4 0.1 2.6 2 0 0 2 2 2 0 Translocation protein Sec62 Auxin_canalis PF05703.11 ETO15311.1 - 1.3 8.9 8.9 0.18 11.7 0.5 2.1 2 0 0 2 2 2 0 Auxin canalisation Secretin_N_2 PF07655.13 ETO15311.1 - 3.9 8.1 21.2 0.33 11.5 15.6 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3381 PF11861.8 ETO15311.1 - 4.4 7.1 26.0 0.12 12.2 3.8 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3381) Spt5_N PF11942.8 ETO15311.1 - 8.1 7.5 22.5 4.4 8.4 12.0 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal SPRY PF00622.28 ETO15312.1 - 0.0062 16.6 0.0 0.014 15.5 0.0 1.6 1 0 0 1 1 1 1 SPRY domain FIN1 PF17300.2 ETO15313.1 - 0.017 14.6 8.1 0.029 13.9 8.1 1.5 1 0 0 1 1 1 0 Filaments in between nuclei protein-1 DUF1664 PF07889.12 ETO15313.1 - 0.19 11.8 2.4 0.41 10.7 1.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) HCR PF07111.12 ETO15314.1 - 0.33 9.0 0.2 0.39 8.7 0.2 1.1 1 0 0 1 1 1 0 Alpha helical coiled-coil rod protein (HCR) V_ATPase_I PF01496.19 ETO15315.1 - 0.93 7.3 6.8 0.039 11.9 0.1 1.8 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family SAM_1 PF00536.30 ETO15316.1 - 0.0039 17.6 0.1 0.0054 17.2 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO15316.1 - 0.011 15.8 0.1 0.017 15.2 0.1 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) HSP90 PF00183.18 ETO15317.1 - 7.7e-56 190.1 3.8 1.1e-55 189.6 3.8 1.1 1 0 0 1 1 1 1 Hsp90 protein HATPase_c PF02518.26 ETO15317.1 - 5.3e-11 43.0 0.1 9.8e-11 42.2 0.1 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO15317.1 - 4.8e-10 39.4 0.1 1.1e-09 38.3 0.1 1.6 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HSP90 PF00183.18 ETO15318.1 - 2.9e-98 330.0 1.9 3.6e-98 329.7 1.9 1.0 1 0 0 1 1 1 1 Hsp90 protein DUF4484 PF14831.6 ETO15318.1 - 0.011 15.7 0.1 0.023 14.7 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) SPRY PF00622.28 ETO15320.1 - 6.1e-05 23.1 0.0 0.00029 21.0 0.0 2.0 2 0 0 2 2 2 1 SPRY domain DUF1281 PF06924.11 ETO15321.1 - 0.068 12.7 1.0 0.13 11.7 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) Spore_II_R PF09551.10 ETO15321.1 - 5.2 7.5 13.1 7.1 7.1 6.8 2.9 1 1 1 2 2 2 0 Stage II sporulation protein R (spore_II_R) Kelch_1 PF01344.25 ETO15322.1 - 0.0011 18.5 0.5 0.042 13.4 0.3 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO15322.1 - 0.015 15.3 0.9 0.98 9.5 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain IL3Ra_N PF18611.1 ETO15322.1 - 0.047 13.7 0.3 0.047 13.7 0.3 2.9 2 1 2 4 4 4 0 IL-3 receptor alpha chain N-terminal domain Kelch_2 PF07646.15 ETO15322.1 - 0.15 12.1 0.7 6.2 7.0 0.2 3.2 3 0 0 3 3 3 0 Kelch motif Adeno_E1B_55K PF01696.17 ETO15323.1 - 0.15 10.7 1.3 0.2 10.3 1.3 1.1 1 0 0 1 1 1 0 Adenovirus EB1 55K protein / large t-antigen WD40 PF00400.32 ETO15324.1 - 0.018 15.9 9.9 0.4 11.6 0.1 3.6 3 1 0 3 3 3 0 WD domain, G-beta repeat DUF971 PF06155.12 ETO15324.1 - 0.068 13.8 0.6 0.12 13.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF971) AfaD PF05775.12 ETO15324.1 - 0.094 13.2 0.2 0.22 11.9 0.2 1.8 1 1 0 1 1 1 0 Enterobacteria AfaD invasin protein VPS38 PF17649.1 ETO15325.1 - 0.051 12.5 0.3 0.11 11.3 0.1 1.5 1 1 1 2 2 2 0 Vacuolar protein sorting 38 SNF2_N PF00176.23 ETO15326.1 - 2.7e-61 207.3 0.1 2.7e-61 207.3 0.1 1.8 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO15326.1 - 4.9e-19 68.7 0.0 2.5e-18 66.4 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 ETO15326.1 - 2.5e-16 59.3 2.4 2.7e-08 33.6 1.0 3.1 3 0 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ETO15326.1 - 1.6e-07 31.5 2.8 4.5e-07 30.0 0.0 3.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Myb_DNA-binding PF00249.31 ETO15326.1 - 0.0015 18.7 0.5 0.012 15.8 0.3 2.5 2 0 0 2 2 2 1 Myb-like DNA-binding domain SLIDE PF09111.10 ETO15326.1 - 0.014 15.4 1.2 0.084 12.9 0.0 2.8 2 0 0 2 2 2 0 SLIDE AMPK1_CBM PF16561.5 ETO15327.1 - 0.04 14.1 0.2 0.24 11.7 0.1 2.3 1 1 1 2 2 2 0 Glycogen recognition site of AMP-activated protein kinase Osmo_CC PF08946.10 ETO15327.1 - 0.05 13.9 2.6 0.13 12.5 2.6 1.7 1 0 0 1 1 1 0 Osmosensory transporter coiled coil Imm74 PF15603.6 ETO15327.1 - 0.22 11.7 2.7 7.2 6.9 1.3 2.7 1 1 1 2 2 2 0 Immunity protein 74 AdoMet_Synthase PF01941.19 ETO15327.1 - 0.58 8.9 4.8 0.8 8.4 1.9 2.1 2 0 0 2 2 2 0 S-adenosylmethionine synthetase (AdoMet synthetase) DUF745 PF05335.13 ETO15327.1 - 1.4 8.6 5.8 0.86 9.3 3.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Pkinase PF00069.25 ETO15328.1 - 3.2e-38 131.6 0.0 7e-38 130.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15328.1 - 1.5e-18 67.0 0.0 3.2e-18 66.0 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO15328.1 - 0.029 13.1 0.3 0.071 11.9 0.0 1.6 2 0 0 2 2 2 0 Fungal protein kinase NIF PF03031.18 ETO15329.1 - 2.1e-17 63.3 0.0 4.4e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase Sporozoite_P67 PF05642.11 ETO15330.1 - 0.39 8.8 2.9 0.38 8.8 2.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Bac_small_YrzI PF09501.10 ETO15330.1 - 0.43 10.7 3.4 1.1 9.5 3.4 1.6 1 0 0 1 1 1 0 Probable sporulation protein (Bac_small_yrzI) Pkinase PF00069.25 ETO15332.1 - 1.5e-18 67.1 1.0 2.2e-18 66.6 1.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15332.1 - 3.5e-10 39.6 0.1 5.5e-10 39.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO15332.1 - 5.7e-06 25.4 0.1 1e-05 24.5 0.1 1.4 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO15332.1 - 0.0014 18.6 0.1 0.011 15.6 0.1 2.0 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO15332.1 - 0.11 11.9 0.5 0.2 11.0 0.5 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family NOA36 PF06524.12 ETO15332.1 - 2 7.7 9.8 4 6.7 9.8 1.4 1 0 0 1 1 1 0 NOA36 protein Spt5_N PF11942.8 ETO15332.1 - 4.2 8.4 20.7 1.1 10.3 16.4 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Sigma70_ner PF04546.13 ETO15332.1 - 8.3 6.2 10.4 0.94 9.3 5.8 1.6 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.14 ETO15332.1 - 8.9 4.5 16.3 13 3.9 16.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Cys_knot PF00007.22 ETO15334.1 - 0.014 15.7 6.1 0.017 15.4 6.1 1.2 1 0 0 1 1 1 0 Cystine-knot domain MgtE PF01769.16 ETO15335.1 - 0.027 14.8 1.7 0.032 14.6 1.7 1.1 1 0 0 1 1 1 0 Divalent cation transporter DUF2070 PF09843.9 ETO15335.1 - 0.17 10.1 4.5 0.19 10.0 4.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF2207 PF09972.9 ETO15335.1 - 1.1 8.0 5.8 1.2 7.8 5.8 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 ETO15336.1 - 1.2e-23 83.0 14.8 1.7e-06 28.6 1.8 4.7 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15336.1 - 3.2e-12 46.6 0.1 0.00044 20.5 0.0 3.7 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15336.1 - 7.9e-09 34.7 0.8 0.0036 16.0 0.1 3.8 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15336.1 - 6e-05 22.5 6.1 0.013 14.9 1.2 3.7 2 1 1 3 3 3 2 WD40-like domain eIF2A PF08662.11 ETO15336.1 - 0.0063 16.4 0.2 6.6 6.6 0.0 2.9 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Methyltransf_FA PF12248.8 ETO15336.1 - 0.07 13.5 1.0 1 9.7 0.0 2.3 2 0 0 2 2 2 0 Farnesoic acid 0-methyl transferase WD40 PF00400.32 ETO15337.1 - 8.4e-06 26.4 9.3 0.061 14.2 0.1 4.7 3 1 1 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO15337.1 - 0.017 13.8 0.6 3.6 6.1 0.1 2.6 2 1 1 3 3 3 0 Nucleoporin Nup120/160 ERAP1_C PF11838.8 ETO15338.1 - 0.045 13.3 0.2 0.25 10.9 0.0 2.1 2 0 0 2 2 2 0 ERAP1-like C-terminal domain GlutR_dimer PF00745.20 ETO15338.1 - 0.48 10.9 3.6 0.74 10.3 1.6 2.4 2 0 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Death PF00531.22 ETO15338.1 - 1.7 8.9 5.3 1.3 9.3 0.1 3.3 3 1 0 4 4 4 0 Death domain HA2 PF04408.23 ETO15339.1 - 4e-20 72.1 4.1 1.3e-19 70.4 0.0 2.6 2 0 0 2 2 2 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETO15339.1 - 5.6e-10 39.5 0.0 1.6e-09 38.0 0.0 1.9 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ETO15339.1 - 9.9e-10 38.8 0.0 2.7e-09 37.4 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SNRNP27 PF08648.12 ETO15340.1 - 2.2e-19 69.2 0.4 2.2e-19 69.2 0.4 2.4 2 1 0 2 2 2 1 U4/U6.U5 small nuclear ribonucleoproteins Caldesmon PF02029.15 ETO15340.1 - 0.057 12.2 32.0 0.072 11.8 32.0 1.0 1 0 0 1 1 1 0 Caldesmon DUF936 PF06075.12 ETO15340.1 - 1.2 8.0 23.4 1.2 7.9 23.4 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) WD40 PF00400.32 ETO15341.1 - 0.0016 19.2 3.3 0.11 13.4 1.4 3.2 2 2 0 2 2 2 1 WD domain, G-beta repeat GlnD_UR_UTase PF08335.11 ETO15341.1 - 0.21 11.7 0.0 0.3 11.2 0.0 1.1 1 0 0 1 1 1 0 GlnD PII-uridylyltransferase Cys_knot PF00007.22 ETO15343.1 - 0.38 11.1 8.4 0.16 12.3 5.5 1.9 2 0 0 2 2 2 0 Cystine-knot domain GATase_7 PF13537.6 ETO15346.1 - 5.1e-11 42.6 0.0 2.8e-10 40.2 0.0 2.0 1 1 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ETO15346.1 - 1.7e-08 34.8 0.0 2.8e-08 34.0 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain Asn_synthase PF00733.21 ETO15347.1 - 0.01 15.6 0.0 0.019 14.7 0.0 1.3 1 1 0 1 1 1 0 Asparagine synthase NAD_synthase PF02540.17 ETO15347.1 - 0.016 14.4 0.0 0.025 13.7 0.0 1.3 1 0 0 1 1 1 0 NAD synthase Ntox5 PF15543.6 ETO15347.1 - 0.033 14.0 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial toxin 5 Asn_synthase PF00733.21 ETO15348.1 - 1.9e-11 44.2 3.7 1.3e-05 25.1 0.1 2.6 1 1 2 3 3 3 2 Asparagine synthase Peptidase_C39_2 PF13529.6 ETO15348.1 - 0.072 13.6 0.2 0.44 11.1 0.5 2.0 2 0 0 2 2 2 0 Peptidase_C39 like family DUF4771 PF15995.5 ETO15348.1 - 0.23 11.7 6.1 0.4 10.9 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4771) PIN_2 PF10130.9 ETO15348.1 - 0.27 11.5 4.0 0.73 10.1 1.0 2.2 1 1 1 2 2 2 0 PIN domain Peptidase_S77 PF03420.13 ETO15348.1 - 1.7 8.2 3.4 10 5.8 0.8 2.3 1 1 1 2 2 2 0 Prohead core protein serine protease NIF PF03031.18 ETO15351.1 - 2.1e-18 66.6 2.2 1.6e-17 63.7 0.2 2.6 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase BRCT PF00533.26 ETO15351.1 - 0.017 15.5 0.1 0.06 13.7 0.1 2.0 1 0 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain PAP1 PF08601.10 ETO15351.1 - 0.019 14.7 0.3 0.019 14.7 0.3 6.3 5 1 1 6 6 6 0 Transcription factor PAP1 Porphobil_deam PF01379.20 ETO15352.1 - 1.9e-63 213.7 0.0 2.4e-63 213.3 0.0 1.1 1 0 0 1 1 1 1 Porphobilinogen deaminase, dipyromethane cofactor binding domain Porphobil_deamC PF03900.15 ETO15352.1 - 3.5e-08 33.7 0.3 6.8e-08 32.8 0.3 1.5 1 0 0 1 1 1 1 Porphobilinogen deaminase, C-terminal domain bHLH-MYC_N PF14215.6 ETO15352.1 - 0.11 12.8 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 bHLH-MYC and R2R3-MYB transcription factors N-terminal DUF2116 PF09889.9 ETO15353.1 - 0.011 15.7 1.0 0.028 14.4 0.5 2.0 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Pkinase PF00069.25 ETO15354.1 - 4.2e-07 29.6 0.1 7.5e-07 28.8 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15354.1 - 0.00014 21.3 0.1 0.00029 20.2 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ETO15355.1 - 1.8e-58 198.0 3.9 2.2e-58 197.7 0.2 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15355.1 - 3.9e-29 101.7 0.3 9.7e-29 100.4 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO15355.1 - 0.00037 19.9 0.6 0.00037 19.9 0.6 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO15355.1 - 0.0013 18.1 0.7 0.0056 16.0 0.0 2.3 3 0 0 3 3 3 1 Kinase-like APH PF01636.23 ETO15355.1 - 0.0021 18.0 0.2 0.0062 16.5 0.2 1.7 1 1 0 1 1 1 1 Phosphotransferase enzyme family WD40 PF00400.32 ETO15356.1 - 0.00015 22.5 5.0 0.72 10.8 0.0 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat B56 PF01603.20 ETO15357.1 - 2.5e-107 359.4 13.8 3.5e-107 359.0 13.8 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) RNA_pol_Rpb1_R PF05001.13 ETO15357.1 - 1.3 9.5 8.4 14 6.3 0.2 2.8 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat Cyt-b5 PF00173.28 ETO15358.1 - 5.7e-08 32.8 0.0 1.2e-07 31.8 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Rad60-SLD PF11976.8 ETO15358.1 - 0.1 12.4 1.0 2.9 7.8 0.1 2.7 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like UQ_con PF00179.26 ETO15359.1 - 2.2e-49 166.7 0.1 4.3e-49 165.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO15359.1 - 0.00046 19.9 0.6 0.0033 17.1 0.0 2.1 1 1 1 2 2 2 1 Prokaryotic E2 family B RWD PF05773.22 ETO15359.1 - 0.0013 19.0 1.3 0.0024 18.1 1.3 1.6 1 1 0 1 1 1 1 RWD domain UEV PF05743.13 ETO15359.1 - 0.1 12.5 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 UEV domain LIM PF00412.22 ETO15360.1 - 1.9e-07 31.2 4.4 1.9e-07 31.2 4.4 3.4 3 2 0 3 3 3 1 LIM domain TPR_12 PF13424.6 ETO15361.1 - 3.8e-16 59.2 7.8 2.9e-07 30.7 0.3 2.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO15361.1 - 1.5e-07 31.0 0.5 1.9e-06 27.6 0.0 2.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO15361.1 - 0.00022 20.9 2.6 0.00029 20.5 0.1 2.5 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO15361.1 - 0.0012 18.6 4.9 0.0019 17.9 4.9 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_2 PF07719.17 ETO15361.1 - 0.0039 17.2 1.5 0.14 12.3 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO15361.1 - 0.016 15.4 1.0 0.06 13.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO15361.1 - 0.04 13.3 1.1 0.054 12.9 1.1 1.2 1 0 0 1 1 1 0 MalT-like TPR region DUF489 PF04356.12 ETO15361.1 - 0.48 10.4 3.4 0.43 10.6 1.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF489) Peptidase_C10 PF01640.17 ETO15361.1 - 1.3 9.3 6.3 1.7 8.9 6.0 1.4 1 1 0 1 1 1 0 Peptidase C10 family Longin PF13774.6 ETO15362.1 - 0.00027 20.9 0.0 0.00027 20.9 0.0 2.0 2 1 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ETO15362.1 - 0.00077 19.2 0.7 0.00077 19.2 0.7 2.0 1 1 1 2 2 2 1 Synaptobrevin GlutR_dimer PF00745.20 ETO15363.1 - 0.14 12.6 4.3 10 6.7 0.9 2.7 2 1 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain DNA_pol_A_exo1 PF01612.20 ETO15364.1 - 1.6e-14 54.0 1.4 4.9e-14 52.4 1.4 1.8 1 1 0 1 1 1 1 3'-5' exonuclease Acatn PF13000.7 ETO15364.1 - 0.022 13.3 0.1 0.034 12.6 0.1 1.3 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 RNF220 PF15926.5 ETO15364.1 - 7.1 6.2 8.5 0.33 10.5 1.4 2.1 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 Glyco_hydro_20 PF00728.22 ETO15365.1 - 0.031 13.7 0.4 0.039 13.4 0.4 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 20, catalytic domain MMR_HSR1 PF01926.23 ETO15366.1 - 2.9e-14 53.1 0.0 4.7e-13 49.2 0.0 2.4 2 0 0 2 2 2 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO15366.1 - 4.2e-06 26.4 0.0 9e-06 25.3 0.0 1.5 1 0 0 1 1 1 1 Ferrous iron transport protein B IIGP PF05049.13 ETO15366.1 - 6.5e-06 25.5 0.0 1.5e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Interferon-inducible GTPase (IIGP) RsgA_GTPase PF03193.16 ETO15366.1 - 0.0005 20.0 0.2 0.0025 17.7 0.0 2.1 1 1 0 2 2 2 1 RsgA GTPase Dynamin_N PF00350.23 ETO15366.1 - 0.00054 20.0 3.1 0.6 10.1 0.0 3.8 2 2 1 4 4 4 2 Dynamin family DUF3295 PF11702.8 ETO15366.1 - 0.00063 19.2 1.9 0.00075 19.0 1.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3295) BUD22 PF09073.10 ETO15366.1 - 0.00088 18.7 8.6 0.0011 18.4 8.6 1.1 1 0 0 1 1 1 1 BUD22 NOA36 PF06524.12 ETO15366.1 - 0.0059 16.0 5.1 0.0079 15.5 5.1 1.2 1 0 0 1 1 1 1 NOA36 protein GTP_EFTU PF00009.27 ETO15366.1 - 0.015 14.8 3.0 0.3 10.6 0.0 3.0 2 2 0 2 2 2 0 Elongation factor Tu GTP binding domain PBP1_TM PF14812.6 ETO15366.1 - 0.026 14.9 12.4 0.071 13.5 12.4 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AAA_30 PF13604.6 ETO15366.1 - 0.038 13.7 0.6 0.069 12.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO15366.1 - 0.048 14.2 0.0 0.048 14.2 0.0 2.7 3 1 0 3 3 3 0 AAA domain AAA_16 PF13191.6 ETO15366.1 - 0.072 13.5 0.0 0.17 12.3 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain RXT2_N PF08595.11 ETO15366.1 - 0.073 13.1 6.5 0.16 12.0 6.5 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 ETO15366.1 - 0.23 11.1 6.4 0.6 9.8 6.4 1.7 1 0 0 1 1 1 0 FAM176 family DMAP1 PF05499.12 ETO15368.1 - 0.023 14.6 0.1 0.029 14.3 0.1 1.1 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) Sec6 PF06046.13 ETO15368.1 - 0.023 13.1 0.2 0.026 12.9 0.2 1.0 1 0 0 1 1 1 0 Exocyst complex component Sec6 DUF4973 PF16343.5 ETO15370.1 - 0.014 15.4 0.2 0.018 15.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4973) UPA PF17217.3 ETO15370.1 - 0.04 13.8 0.1 0.056 13.3 0.1 1.2 1 0 0 1 1 1 0 UPA domain AGH PF17558.2 ETO15370.1 - 0.091 12.9 0.0 0.14 12.3 0.0 1.2 1 0 0 1 1 1 0 Androgenic gland hormone zf-HC5HC2H_2 PF13832.6 ETO15371.1 - 7 6.9 11.6 0.075 13.2 3.6 1.8 2 0 0 2 2 2 0 PHD-zinc-finger like domain Peptidase_C48 PF02902.19 ETO15372.1 - 3e-27 95.9 7.7 3e-27 95.9 7.7 2.5 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C14 PF00656.22 ETO15373.1 - 7.7e-05 22.8 0.0 0.0001 22.4 0.0 1.2 1 0 0 1 1 1 1 Caspase domain WD40 PF00400.32 ETO15374.1 - 0.00094 20.0 1.6 0.032 15.1 0.3 2.4 2 1 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO15374.1 - 0.012 14.3 0.0 0.012 14.2 0.0 1.0 1 0 0 1 1 1 0 Nucleoporin Nup120/160 C1_2 PF03107.16 ETO15375.1 - 0.00061 20.1 1.8 0.0014 18.9 1.8 1.7 1 0 0 1 1 1 1 C1 domain C1_1 PF00130.22 ETO15375.1 - 0.0038 17.1 5.8 0.0082 16.0 5.8 1.5 1 0 0 1 1 1 1 Phorbol esters/diacylglycerol binding domain (C1 domain) Prok-RING_1 PF14446.6 ETO15375.1 - 0.024 14.6 4.1 0.024 14.6 4.1 1.9 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 PHD PF00628.29 ETO15375.1 - 0.026 14.4 5.4 0.081 12.8 5.4 1.9 1 0 0 1 1 1 0 PHD-finger E6 PF00518.17 ETO15377.1 - 0.00057 20.3 2.9 0.00065 20.1 1.4 1.9 2 0 0 2 2 2 1 Early Protein (E6) Secretin_N_2 PF07655.13 ETO15377.1 - 0.024 15.2 0.3 0.057 14.0 0.3 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain SATase_N PF06426.14 ETO15377.1 - 0.13 12.7 4.6 0.091 13.2 1.3 2.2 1 1 1 2 2 2 0 Serine acetyltransferase, N-terminal ArgoMid PF16487.5 ETO15377.1 - 0.23 11.7 9.0 6.4 7.1 0.9 3.6 2 1 2 4 4 4 0 Mid domain of argonaute Lebercilin PF15619.6 ETO15377.1 - 0.36 10.5 26.5 0.24 11.0 24.7 1.7 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Y2_Tnp PF04986.13 ETO15377.1 - 0.54 10.3 3.0 0.34 11.0 0.4 1.9 1 1 1 2 2 2 0 Putative transposase FAM184 PF15665.5 ETO15377.1 - 0.62 9.8 23.8 0.36 10.6 16.8 2.4 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B SPATA24 PF15175.6 ETO15377.1 - 0.68 9.8 24.2 0.8 9.6 15.9 2.9 1 1 1 2 2 2 0 Spermatogenesis-associated protein 24 DUF1910 PF08928.10 ETO15377.1 - 2.6 8.1 10.1 8.6 6.4 9.3 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1910) YtxH PF12732.7 ETO15377.1 - 2.7 8.6 5.6 1.2e+02 3.3 5.2 3.1 1 1 0 1 1 1 0 YtxH-like protein O-antigen_lig PF13425.6 ETO15379.1 - 0.051 12.4 1.1 0.079 11.7 1.1 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Med19 PF10278.9 ETO15379.1 - 0.12 12.3 6.8 0.19 11.7 6.8 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 WD40 PF00400.32 ETO15380.1 - 1e-39 133.8 25.9 4e-07 30.6 0.0 8.3 7 3 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO15380.1 - 1.6e-08 33.7 3.9 0.018 13.7 0.1 5.1 1 1 4 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15380.1 - 2.5e-08 34.1 0.0 0.072 13.4 0.0 5.0 5 0 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15380.1 - 3e-06 26.8 1.3 1.9 7.7 0.0 4.7 3 1 1 4 4 4 3 WD40-like domain Caleosin PF05042.13 ETO15382.1 - 0.071 13.0 0.1 0.11 12.5 0.1 1.2 1 0 0 1 1 1 0 Caleosin related protein WD40 PF00400.32 ETO15383.1 - 1.8e-11 44.3 2.4 3.5e-05 24.5 0.1 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO15383.1 - 0.018 15.1 1.1 11 6.1 0.1 3.1 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Marek_SORF3 PF07153.11 ETO15383.1 - 0.05 12.9 0.0 0.33 10.3 0.0 1.8 1 1 1 2 2 2 0 Marek's disease-like virus SORF3 protein 2OG-FeII_Oxy_2 PF13532.6 ETO15384.1 - 9.7e-30 104.2 0.1 1.7e-29 103.4 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 ETO15385.1 - 1.5e-124 402.2 51.2 8.7e-09 35.9 0.1 16.5 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15385.1 - 1.3e-18 67.1 20.6 0.14 12.5 0.0 12.0 1 1 10 13 13 13 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15385.1 - 8.6e-18 64.4 7.9 0.096 11.6 0.0 11.8 1 1 8 11 11 11 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15385.1 - 7e-13 48.6 30.6 8.7e-05 22.0 1.3 9.1 4 3 3 8 8 8 6 WD40-like domain NACHT PF05729.12 ETO15385.1 - 3.8e-10 39.9 0.0 8.1e-10 38.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO15385.1 - 1.8e-06 27.5 7.4 3.5e-06 26.5 7.4 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO15385.1 - 9.9e-05 22.9 0.6 0.0015 19.1 0.0 3.3 3 0 0 3 3 3 1 AAA domain Pentapeptide_4 PF13599.6 ETO15385.1 - 0.00012 22.2 0.3 0.00037 20.6 0.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO15385.1 - 0.0057 16.8 1.7 0.014 15.6 1.7 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO15385.1 - 0.0077 16.5 0.0 0.031 14.5 0.0 2.1 1 0 0 1 1 1 1 AAA domain CUE PF02845.16 ETO15385.1 - 0.021 14.5 1.3 0.046 13.4 0.2 2.3 2 0 0 2 2 2 0 CUE domain DUF5319 PF17252.2 ETO15385.1 - 0.082 13.1 0.2 13 6.1 0.0 4.0 5 0 0 5 5 3 0 Family of unknown function (DUF5319) ABC_tran PF00005.27 ETO15385.1 - 0.21 12.1 3.2 0.29 11.7 0.1 2.8 2 0 0 2 2 2 0 ABC transporter PD40 PF07676.12 ETO15385.1 - 0.65 10.0 16.0 33 4.6 0.1 7.2 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO15385.1 - 3.7 7.6 11.9 9.4 6.3 0.0 7.4 10 2 0 10 10 9 0 Ciliary BBSome complex subunit 2, middle region 3-HAO PF06052.12 ETO15386.1 - 2.2e-43 147.5 0.1 3.5e-43 146.8 0.1 1.3 1 0 0 1 1 1 1 3-hydroxyanthranilic acid dioxygenase Cupin_2 PF07883.11 ETO15386.1 - 0.00057 19.5 0.1 0.00099 18.8 0.1 1.4 1 0 0 1 1 1 1 Cupin domain AraC_binding PF02311.19 ETO15386.1 - 0.0081 16.1 0.1 0.014 15.3 0.1 1.4 1 0 0 1 1 1 1 AraC-like ligand binding domain Cupin_1 PF00190.22 ETO15386.1 - 0.15 11.7 0.0 0.21 11.2 0.0 1.2 1 0 0 1 1 1 0 Cupin Gag_p17 PF00540.18 ETO15387.1 - 0.083 12.9 1.8 0.13 12.2 1.8 1.4 1 0 0 1 1 1 0 gag gene protein p17 (matrix protein) DUF2452 PF10504.9 ETO15387.1 - 0.27 10.7 10.4 3.6 7.0 8.6 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF2452) BBS2_N PF14781.6 ETO15387.1 - 0.4 10.6 4.5 0.24 11.3 2.5 1.8 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, N-terminal FixO PF02433.15 ETO15387.1 - 0.46 9.9 3.7 0.58 9.6 3.7 1.2 1 0 0 1 1 1 0 Cytochrome C oxidase, mono-heme subunit/FixO I_LWEQ PF01608.17 ETO15387.1 - 3.5 7.9 11.9 5.7 7.2 11.9 1.3 1 0 0 1 1 1 0 I/LWEQ domain LPP PF04728.13 ETO15387.1 - 4.2 7.9 14.5 3.5 8.1 0.3 3.3 1 1 1 2 2 2 0 Lipoprotein leucine-zipper FlxA PF14282.6 ETO15387.1 - 7.4 6.6 24.4 1.7 8.6 15.4 2.4 1 1 1 2 2 2 0 FlxA-like protein Spore_III_AF PF09581.10 ETO15388.1 - 0.074 13.1 1.2 0.12 12.4 1.2 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) PH PF00169.29 ETO15389.1 - 4.7e-17 62.4 3.7 6.1e-17 62.0 0.0 2.5 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 ETO15389.1 - 0.00014 22.0 0.0 0.00014 22.0 0.0 2.2 3 0 0 3 3 3 1 Pleckstrin homology domain PH_11 PF15413.6 ETO15389.1 - 0.0016 18.8 0.8 0.0016 18.8 0.8 3.9 3 3 0 3 3 3 1 Pleckstrin homology domain PH_2 PF08458.10 ETO15389.1 - 0.0068 16.7 0.1 0.019 15.3 0.0 1.8 2 0 0 2 2 2 1 Plant pleckstrin homology-like region PH_16 PF17838.1 ETO15389.1 - 0.016 15.0 0.0 0.033 14.0 0.0 1.4 1 0 0 1 1 1 0 PH domain Tudor-knot PF11717.8 ETO15389.1 - 0.12 12.3 1.1 1.3 9.0 1.1 2.4 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Terminase_4 PF05119.12 ETO15390.1 - 0.11 13.0 4.6 1.3 9.5 0.2 2.1 2 0 0 2 2 2 0 Phage terminase, small subunit KxDL PF10241.9 ETO15391.1 - 0.14 12.5 4.8 0.49 10.7 4.8 2.0 1 0 0 1 1 1 0 Uncharacterized conserved protein HR1 PF02185.16 ETO15391.1 - 6.5 7.0 13.9 0.073 13.2 4.7 2.5 2 0 0 2 2 2 0 Hr1 repeat PriCT_2 PF08707.11 ETO15392.1 - 0.14 12.5 1.6 0.55 10.6 1.6 2.0 1 0 0 1 1 1 0 Primase C terminal 2 (PriCT-2) Cys_rich_KTR PF14205.6 ETO15392.1 - 0.16 11.8 0.2 0.16 11.8 0.2 2.9 3 0 0 3 3 3 0 Cysteine-rich KTR TORC_N PF12884.7 ETO15393.1 - 0.2 12.4 0.1 0.2 12.4 0.1 2.2 2 0 0 2 2 2 0 Transducer of regulated CREB activity, N terminus DUF3644 PF12358.8 ETO15393.1 - 0.5 10.9 4.0 0.66 10.5 0.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3644) HsbA PF12296.8 ETO15394.1 - 0.42 11.1 6.4 3.3 8.1 3.2 2.9 2 1 1 3 3 3 0 Hydrophobic surface binding protein A SLATT_6 PF18169.1 ETO15394.1 - 1.2 8.7 7.6 0.19 11.3 1.9 2.4 1 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 6 Lipoprotein_6 PF01441.19 ETO15394.1 - 2.8 7.9 13.2 0.058 13.4 2.0 2.9 2 1 1 3 3 3 0 Lipoprotein DASH_Dam1 PF08653.10 ETO15394.1 - 6 6.7 6.1 4.5 7.1 0.4 3.1 3 0 0 3 3 3 0 DASH complex subunit Dam1 Golgin_A5 PF09787.9 ETO15394.1 - 7.7 5.9 24.8 5.4 6.4 7.9 2.3 1 1 0 2 2 2 0 Golgin subfamily A member 5 zf-RanBP PF00641.18 ETO15395.1 - 0.012 14.9 9.0 0.023 14.0 9.0 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others Toprim PF01751.22 ETO15395.1 - 0.069 13.4 0.0 0.24 11.6 0.0 1.9 1 0 0 1 1 1 0 Toprim domain DUF1336 PF07059.12 ETO15396.1 - 2.8e-37 129.0 0.0 5.8e-25 88.7 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF1336) DUF4471 PF14740.6 ETO15397.1 - 2.9e-29 102.3 2.3 2.9e-29 102.3 2.3 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4471) Strumpellin PF10266.9 ETO15397.1 - 0.0018 16.1 0.7 0.002 15.9 0.7 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin DUF294_C PF10335.9 ETO15397.1 - 0.052 13.3 0.0 0.078 12.8 0.0 1.3 1 0 0 1 1 1 0 Putative nucleotidyltransferase substrate binding domain NAD_binding_5 PF07994.12 ETO15397.1 - 0.16 11.3 0.1 0.21 10.9 0.1 1.1 1 0 0 1 1 1 0 Myo-inositol-1-phosphate synthase NTP_transf_2 PF01909.23 ETO15398.1 - 9.7e-06 25.8 0.0 2e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO15398.1 - 6.6e-05 22.9 0.0 0.00015 21.8 0.0 1.6 1 0 0 1 1 1 1 Polymerase beta, Nucleotidyltransferase DUF294 PF03445.13 ETO15398.1 - 0.015 15.1 0.0 0.026 14.3 0.0 1.4 1 0 0 1 1 1 0 Putative nucleotidyltransferase DUF294 PAP_assoc PF03828.19 ETO15398.1 - 0.016 15.4 2.1 0.043 14.0 2.1 1.8 1 0 0 1 1 1 0 Cid1 family poly A polymerase G-alpha PF00503.20 ETO15399.1 - 3.2e-35 121.9 8.2 5.1e-35 121.3 8.2 1.3 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO15399.1 - 4.9e-07 29.4 0.1 0.0003 20.3 0.2 2.8 2 1 0 2 2 2 2 ADP-ribosylation factor family AAA_28 PF13521.6 ETO15399.1 - 0.0069 16.7 0.2 0.023 14.9 0.2 1.9 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO15399.1 - 0.077 13.5 0.2 0.21 12.1 0.1 1.9 2 1 0 2 2 2 0 ABC transporter Baculo_LEF5_C PF11792.8 ETO15399.1 - 0.089 12.5 0.6 0.47 10.2 0.1 2.4 2 0 0 2 2 2 0 Baculoviridae late expression factor 5 C-terminal domain PRESAN PF09687.10 ETO15399.1 - 3.7 8.1 13.7 1.1 9.8 5.1 2.9 3 0 0 3 3 3 0 Plasmodium RESA N-terminal WD40 PF00400.32 ETO15401.1 - 7.9e-35 118.3 33.6 7.4e-07 29.8 0.7 8.5 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15401.1 - 3.7e-15 56.0 2.4 0.0013 18.9 0.0 6.1 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15401.1 - 1.7e-14 53.4 11.9 0.0013 17.5 0.1 5.9 2 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15401.1 - 1.4e-06 27.8 4.9 0.011 15.1 0.9 5.0 2 2 3 5 5 5 2 WD40-like domain DUF4979 PF16351.5 ETO15401.1 - 3 8.1 6.1 12 6.1 0.0 4.3 4 2 1 5 5 5 0 Domain of unknown function (DUF4979) Csm1_N PF18504.1 ETO15401.1 - 8.7 6.8 9.8 2.6 8.4 3.8 2.5 1 1 1 2 2 2 0 Csm1 N-terminal domain zf-TRAF PF02176.18 ETO15402.1 - 1.4e-06 28.9 2.3 1.4e-06 28.9 2.3 2.8 2 2 0 2 2 2 1 TRAF-type zinc finger zf-MIZ PF02891.20 ETO15402.1 - 0.44 10.3 5.2 0.81 9.5 0.8 3.1 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger Bunya_nucleocap PF00952.17 ETO15404.1 - 0.003 17.6 0.1 0.0036 17.4 0.1 1.1 1 0 0 1 1 1 1 Bunyavirus nucleocapsid (N) protein ThiS-like PF14453.6 ETO15404.1 - 0.0049 16.9 0.1 0.019 15.0 0.0 2.1 2 0 0 2 2 2 1 ThiS-like ubiquitin DUF1870 PF08965.10 ETO15404.1 - 0.018 15.1 0.1 0.029 14.4 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1870) Rhodanese PF00581.20 ETO15405.1 - 0.0033 17.9 0.0 0.0065 17.0 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Kelch_1 PF01344.25 ETO15406.1 - 1.7e-09 37.1 1.2 0.00085 18.9 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO15406.1 - 5.4e-06 26.5 0.3 0.016 15.5 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO15406.1 - 0.013 15.4 0.0 0.72 9.9 0.0 2.7 2 0 0 2 2 2 0 Galactose oxidase, central domain Vps39_1 PF10366.9 ETO15407.1 - 0.68 10.2 11.2 0.16 12.3 2.5 2.4 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 1 DUF3533 PF12051.8 ETO15407.1 - 3.2 6.6 4.6 3.6 6.4 4.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3533) HNOBA PF07701.14 ETO15408.1 - 0.0093 15.4 1.4 0.0093 15.4 1.4 2.3 2 0 0 2 2 2 1 Heme NO binding associated DUF4746 PF15928.5 ETO15408.1 - 0.32 10.4 27.8 0.39 10.1 9.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Eapp_C PF10238.9 ETO15408.1 - 0.65 10.1 11.7 0.035 14.2 2.2 2.7 2 0 0 2 2 2 0 E2F-associated phosphoprotein RNA_pol_Rpc4 PF05132.14 ETO15408.1 - 0.76 10.2 19.9 0.16 12.4 10.2 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 HA2 PF04408.23 ETO15408.1 - 0.82 10.0 9.2 0.11 12.8 2.9 2.5 2 0 0 2 2 2 0 Helicase associated domain (HA2) EMC3_TMCO1 PF01956.16 ETO15408.1 - 0.91 9.2 2.8 1.8 8.3 2.8 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RNA_polI_A34 PF08208.11 ETO15408.1 - 2 8.5 41.2 0.071 13.2 23.8 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 SLC12 PF03522.15 ETO15408.1 - 2.1 7.3 23.1 0.15 11.1 7.0 2.2 2 0 0 2 2 2 0 Solute carrier family 12 DUF1682 PF07946.14 ETO15408.1 - 2.1 7.5 32.3 0.99 8.5 1.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1682) DUF2052 PF09747.9 ETO15408.1 - 2.4 8.3 32.9 1.5 8.9 15.3 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) RPOL_N PF14700.6 ETO15408.1 - 2.8 7.3 17.6 0.032 13.6 6.8 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal RR_TM4-6 PF06459.12 ETO15408.1 - 3 7.6 32.6 0.3 10.9 16.7 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 ETO15408.1 - 5.3 7.3 36.7 0.21 11.9 20.4 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Tim54 PF11711.8 ETO15408.1 - 5.7 5.6 25.8 0.66 8.7 11.6 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 ETO15408.1 - 5.9 5.6 19.0 0.026 13.3 6.5 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_hydro_31 PF01055.26 ETO15409.1 - 1.9e-42 146.0 11.1 4.1e-42 144.9 11.1 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 31 Acyl-CoA_dh_1 PF00441.24 ETO15411.1 - 1e-36 126.4 0.1 1.3e-36 126.1 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO15411.1 - 2.6e-19 69.2 0.0 4.8e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETO15411.1 - 7.5e-11 42.4 0.0 9.4e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ETO15411.1 - 4.1e-06 26.6 0.3 2.2e-05 24.2 0.3 1.9 1 1 0 1 1 1 1 4-hydroxyphenylacetate 3-hydroxylase N terminal Acyl-CoA_dh_N PF02771.16 ETO15412.1 - 1.3e-30 106.4 0.0 1.7e-30 105.9 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Pox_A_type_inc PF04508.12 ETO15413.1 - 0.032 14.1 0.7 0.032 14.1 0.7 2.1 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Utp14 PF04615.13 ETO15413.1 - 3.6 6.0 28.7 4.6 5.7 28.7 1.1 1 0 0 1 1 1 0 Utp14 protein zf-C3HC4_3 PF13920.6 ETO15414.1 - 6.5e-10 38.7 16.2 6.5e-10 38.7 16.2 2.7 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO15414.1 - 0.0048 16.7 15.6 0.0048 16.7 15.6 3.5 2 2 0 2 2 2 1 Prokaryotic RING finger family 4 zf-met PF12874.7 ETO15415.1 - 0.0039 17.5 8.2 0.0089 16.4 8.2 1.7 1 0 0 1 1 1 1 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ETO15415.1 - 0.02 15.2 8.0 0.02 15.2 8.0 2.2 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding PadR PF03551.14 ETO15415.1 - 0.039 13.9 0.7 0.11 12.5 0.7 1.6 1 0 0 1 1 1 0 Transcriptional regulator PadR-like family CIAPIN1 PF05093.13 ETO15415.1 - 0.14 12.7 0.3 0.14 12.7 0.3 2.8 2 1 1 3 3 3 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis TMPIT PF07851.13 ETO15415.1 - 0.9 8.7 11.4 1.8 7.7 11.4 1.6 1 0 0 1 1 1 0 TMPIT-like protein UPF0697 PF15117.6 ETO15415.1 - 5.8 7.1 7.5 11 6.2 2.9 2.4 1 1 1 2 2 2 0 Uncharacterised protein family UPF0697 Peptidase_C14 PF00656.22 ETO15416.1 - 2e-08 34.5 0.2 4.5e-08 33.4 0.2 1.6 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO15416.1 - 1.8e-06 27.8 0.7 0.048 13.7 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO15416.1 - 6.5e-06 25.6 0.1 0.011 15.3 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO15416.1 - 0.00039 20.4 0.0 0.0017 18.3 0.0 2.1 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO15416.1 - 0.0004 20.6 0.0 0.007 16.6 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO15416.1 - 0.018 15.0 3.1 25 5.0 0.0 4.6 5 0 0 5 5 5 0 Kelch motif DUF3557 PF12078.8 ETO15416.1 - 0.031 14.2 1.9 0.084 12.8 1.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3557) Peptidase_M15_3 PF08291.11 ETO15416.1 - 0.086 12.9 0.0 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 Peptidase M15 Kelch_6 PF13964.6 ETO15416.1 - 0.26 11.6 2.6 22 5.5 0.1 3.5 5 0 0 5 5 5 0 Kelch motif VWA_CoxE PF05762.14 ETO15418.1 - 4.3e-05 23.0 0.0 5.5e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein VWA PF00092.28 ETO15418.1 - 6.4e-05 23.3 0.0 7.8e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain SIN1 PF05422.12 ETO15419.1 - 0.0028 18.2 0.4 0.0035 17.9 0.4 1.3 1 0 0 1 1 1 1 Stress-activated map kinase interacting protein 1 (SIN1) DDRGK PF09756.9 ETO15421.1 - 6.5 6.3 18.1 9.8 5.7 18.1 1.3 1 0 0 1 1 1 0 DDRGK domain Aldedh PF00171.22 ETO15423.1 - 3.9e-24 85.0 0.0 5.4e-24 84.5 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Ank_2 PF12796.7 ETO15424.1 - 1.7e-06 28.5 0.3 0.008 16.8 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO15424.1 - 0.00016 21.8 0.0 2.8 8.8 0.0 3.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ETO15424.1 - 0.00058 20.4 0.0 4.9 7.9 0.0 3.4 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO15424.1 - 0.00097 19.4 0.0 0.77 10.2 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeats (many copies) LuxT_C PF18285.1 ETO15424.1 - 0.022 15.3 0.0 0.072 13.6 0.0 1.9 2 0 0 2 2 2 0 Tetracycline repressor LuxT C-terminal domain DUF5083 PF16890.5 ETO15425.1 - 0.074 12.8 0.0 0.074 12.8 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5083) Ninjurin PF04923.12 ETO15425.1 - 0.09 12.7 2.0 0.46 10.5 2.0 2.2 1 0 0 1 1 1 0 Ninjurin WD40 PF00400.32 ETO15426.1 - 0.00012 22.8 4.7 0.017 16.0 0.3 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15426.1 - 0.0054 17.0 0.1 0.0083 16.4 0.1 1.4 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15426.1 - 0.013 14.8 4.9 0.014 14.8 0.5 1.9 1 1 1 2 2 2 0 WD40-like domain NHL PF01436.21 ETO15426.1 - 0.15 12.1 0.4 0.15 12.1 0.4 2.0 2 0 0 2 2 2 0 NHL repeat Connexin PF00029.19 ETO15427.1 - 0.0089 15.8 1.2 0.0091 15.8 1.2 1.1 1 0 0 1 1 1 1 Connexin Tau95_N PF17682.1 ETO15427.1 - 0.014 15.6 3.0 0.017 15.3 3.0 1.2 1 0 0 1 1 1 0 Tau95 Triple barrel domain DUF3464 PF11947.8 ETO15427.1 - 0.06 13.1 1.0 0.06 13.1 1.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SARAF PF06682.12 ETO15427.1 - 0.11 12.2 0.3 0.1 12.2 0.3 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Peptidase_S49_N PF08496.10 ETO15427.1 - 1.6 8.8 9.4 1.9 8.5 9.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SR-25 PF10500.9 ETO15427.1 - 4.6 6.8 16.5 5.7 6.5 16.5 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Cpn60_TCP1 PF00118.24 ETO15429.1 - 2e-94 317.0 0.1 2.2e-94 316.8 0.1 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Adeno_E1A PF02703.14 ETO15429.1 - 0.15 11.7 0.0 0.22 11.1 0.0 1.2 1 0 0 1 1 1 0 Early E1A protein Ras PF00071.22 ETO15430.1 - 0.002 17.8 0.0 0.0028 17.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Transposase_1 PF01359.18 ETO15430.1 - 0.13 12.1 0.9 0.49 10.3 0.9 1.8 1 1 0 1 1 1 0 Transposase (partial DDE domain) WD40 PF00400.32 ETO15431.1 - 1e-37 127.4 25.4 8.8e-07 29.5 0.9 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15431.1 - 7.3e-11 42.2 5.8 0.018 15.3 0.0 5.8 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15431.1 - 2.8e-08 32.9 7.8 0.03 13.0 0.1 5.2 2 1 2 5 5 5 3 Nucleoporin Nup120/160 Lebercilin PF15619.6 ETO15431.1 - 0.0029 17.3 11.6 0.0029 17.3 11.6 2.3 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease Csm1_N PF18504.1 ETO15431.1 - 0.17 12.3 18.1 0.2 12.0 3.1 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain AvrM-A PF18241.1 ETO15431.1 - 0.49 10.8 10.9 1.1 9.7 10.9 1.6 1 0 0 1 1 1 0 Flax-rust effector AvrM-A YabA PF06156.13 ETO15431.1 - 0.57 10.9 20.7 7.5 7.2 11.5 3.6 3 0 0 3 3 3 0 Initiation control protein YabA PRKG1_interact PF15898.5 ETO15431.1 - 1.8 9.5 15.4 2.4 9.1 7.1 2.5 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF641 PF04859.12 ETO15431.1 - 2.8 8.3 16.9 2.2 8.6 7.5 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Cas_CXXC_CXXC PF09706.10 ETO15431.1 - 9.1 6.6 13.9 1.1 9.5 0.1 4.5 5 0 0 5 5 5 0 CRISPR-associated protein (Cas_CXXC_CXXC) PKcGMP_CC PF16808.5 ETO15431.1 - 9.5 6.2 16.0 1.1 9.1 2.8 3.5 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-C3HC4_2 PF13923.6 ETO15432.1 - 0.63 9.9 7.8 2.3 8.1 5.7 2.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO15432.1 - 0.96 9.4 6.4 8.3 6.4 1.8 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Methyltransf_28 PF02636.17 ETO15433.1 - 2.2e-16 60.3 0.0 2.5e-16 60.1 0.0 1.1 1 0 0 1 1 1 1 Putative S-adenosyl-L-methionine-dependent methyltransferase WD40 PF00400.32 ETO15434.1 - 2.5e-05 24.9 0.0 0.0064 17.3 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat XH PF03469.14 ETO15434.1 - 0.097 12.6 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 XH domain FTSW_RODA_SPOVE PF01098.19 ETO15435.1 - 0.097 11.6 0.0 0.14 11.1 0.0 1.2 1 0 0 1 1 1 0 Cell cycle protein Trans_coact PF16805.5 ETO15438.1 - 0.11 12.6 0.3 0.26 11.4 0.3 1.6 1 0 0 1 1 1 0 Phage late-transcription coactivator Pkinase PF00069.25 ETO15439.1 - 5.8e-34 117.7 1.0 1.9e-33 116.0 1.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15439.1 - 4.6e-22 78.5 3.5 3.2e-21 75.8 3.5 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO15439.1 - 1.7e-05 23.8 1.5 8.6e-05 21.5 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO15439.1 - 0.013 14.9 3.8 0.025 14.0 1.9 2.2 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family RP854 PF17460.2 ETO15440.1 - 0.011 15.5 0.2 0.029 14.1 0.2 1.7 1 0 0 1 1 1 0 Uncharacterized protein RP854 RYDR_ITPR PF01365.21 ETO15440.1 - 0.036 13.5 6.9 0.075 12.4 6.6 1.6 1 1 0 1 1 1 0 RIH domain Ndc1_Nup PF09531.10 ETO15440.1 - 0.059 12.1 11.8 0.083 11.6 11.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Baculo_PEP_C PF04513.12 ETO15440.1 - 0.089 12.8 6.5 0.15 12.1 6.5 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus LMBR1 PF04791.16 ETO15440.1 - 0.13 11.1 12.6 0.2 10.5 12.6 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein COG5 PF10392.9 ETO15440.1 - 0.32 11.2 10.5 0.71 10.0 10.5 1.6 1 0 0 1 1 1 0 Golgi transport complex subunit 5 DegT_DnrJ_EryC1 PF01041.17 ETO15440.1 - 0.92 8.7 8.1 0.8 8.9 6.5 1.7 2 0 0 2 2 2 0 DegT/DnrJ/EryC1/StrS aminotransferase family Lectin_N PF03954.14 ETO15440.1 - 1 9.1 9.6 2.5 7.9 9.6 1.6 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Exonuc_VII_L PF02601.15 ETO15440.1 - 2 7.9 15.8 3.1 7.3 15.8 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit RecG_N PF17190.4 ETO15440.1 - 2.3 9.0 8.5 2.8 8.8 5.9 2.5 1 1 1 2 2 2 0 RecG N-terminal helical domain ZYG-11_interact PF05884.12 ETO15440.1 - 3.1 7.1 8.0 5.4 6.3 8.0 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 Bac_small_YrzI PF09501.10 ETO15442.1 - 0.0001 22.3 6.2 0.0001 22.3 6.2 3.2 1 1 1 2 2 2 1 Probable sporulation protein (Bac_small_yrzI) DUF1451 PF07295.11 ETO15442.1 - 0.067 13.2 11.9 0.11 12.5 11.3 1.8 1 1 0 1 1 1 0 Zinc-ribbon containing domain AcylCoA_dehyd_C PF12186.8 ETO15442.1 - 1.4 9.1 8.7 5.4 7.2 1.1 2.9 1 1 1 2 2 2 0 Acyl-CoA dehydrogenase C terminal DUF3552 PF12072.8 ETO15442.1 - 2.3 7.6 29.1 1.5 8.2 25.5 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Spt5_N PF11942.8 ETO15442.1 - 3.1 8.8 15.0 0.43 11.6 10.1 2.0 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal DUF948 PF06103.11 ETO15442.1 - 9 6.6 6.4 7.4 6.9 2.4 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Tim54 PF11711.8 ETO15443.1 - 0.1 11.4 3.4 0.17 10.7 3.4 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TMPIT PF07851.13 ETO15443.1 - 0.14 11.3 3.8 0.24 10.6 3.8 1.3 1 0 0 1 1 1 0 TMPIT-like protein GOLD_2 PF13897.6 ETO15443.1 - 0.61 10.6 4.0 0.4 11.2 2.0 1.7 2 1 0 2 2 2 0 Golgi-dynamics membrane-trafficking Presenilin PF01080.17 ETO15443.1 - 3.1 6.5 6.6 3.6 6.2 6.6 1.1 1 0 0 1 1 1 0 Presenilin Orf78 PF06024.12 ETO15443.1 - 4.5 7.6 7.2 2.2e+02 2.2 8.4 2.5 2 0 0 2 2 2 0 Orf78 (ac78) Kelch_6 PF13964.6 ETO15444.1 - 7e-05 23.0 2.1 3.6 8.0 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO15444.1 - 0.00028 20.8 0.2 4.8 7.3 0.2 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO15444.1 - 0.00081 18.9 0.1 0.64 9.6 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO15444.1 - 0.0048 16.8 1.0 16 5.7 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Peptidase_M19 PF01244.21 ETO15445.1 - 0.0033 16.7 1.0 0.0045 16.2 1.0 1.2 1 0 0 1 1 1 1 Membrane dipeptidase (Peptidase family M19) Glyco_trans_4_2 PF13477.6 ETO15445.1 - 0.029 14.4 1.8 6.8 6.7 0.2 2.7 2 1 1 3 3 3 0 Glycosyl transferase 4-like UPF0180 PF03698.13 ETO15445.1 - 0.071 13.3 2.6 0.11 12.7 0.9 2.3 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0180) DUF1284 PF06935.11 ETO15445.1 - 0.4 11.1 2.6 0.73 10.3 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1284) AdoHcyase_NAD PF00670.21 ETO15446.1 - 4.3e-28 98.4 2.1 1.5e-26 93.4 0.4 2.4 1 1 0 2 2 2 1 S-adenosyl-L-homocysteine hydrolase, NAD binding domain AdoHcyase PF05221.17 ETO15446.1 - 2.3e-08 33.6 0.0 3.1e-08 33.1 0.0 1.1 1 0 0 1 1 1 1 S-adenosyl-L-homocysteine hydrolase IlvN PF07991.12 ETO15446.1 - 0.03 13.9 0.0 0.043 13.4 0.0 1.3 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain TrkA_N PF02254.18 ETO15446.1 - 0.041 14.1 0.0 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 TrkA-N domain NAD_binding_7 PF13241.6 ETO15446.1 - 0.13 12.7 0.0 0.25 11.8 0.0 1.5 1 1 0 1 1 1 0 Putative NAD(P)-binding RVT_1 PF00078.27 ETO15447.1 - 4.3e-14 52.6 0.1 5.3e-14 52.3 0.1 1.0 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SRA PF18491.1 ETO15448.1 - 0.0026 17.9 0.5 0.0032 17.6 0.5 1.1 1 0 0 1 1 1 1 SET and RING associated domain XRN_N PF03159.18 ETO15448.1 - 0.012 15.0 1.1 0.016 14.6 0.9 1.4 1 1 0 1 1 1 0 XRN 5'-3' exonuclease N-terminus CT_C_D PF02682.16 ETO15448.1 - 0.044 13.5 0.0 0.049 13.4 0.0 1.1 1 0 0 1 1 1 0 Carboxyltransferase domain, subdomain C and D Tsg PF04668.12 ETO15448.1 - 0.15 12.8 1.3 0.19 12.4 1.3 1.1 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region MCCD1 PF15707.5 ETO15449.1 - 0.084 13.3 1.2 0.14 12.6 0.3 2.0 2 0 0 2 2 2 0 Mitochondrial coiled-coil domain protein 1 Mito_carr PF00153.27 ETO15450.1 - 2.4e-06 27.3 0.6 0.34 10.9 0.0 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein Mito_carr PF00153.27 ETO15451.1 - 7.9e-18 64.2 0.4 2.3e-14 53.1 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein Filament PF00038.21 ETO15452.1 - 0.054 13.1 57.5 0.034 13.7 55.9 1.5 1 1 0 1 1 1 0 Intermediate filament protein Mitofilin PF09731.9 ETO15452.1 - 0.13 11.0 50.2 0.18 10.6 50.2 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein WD40 PF00400.32 ETO15453.1 - 9.2e-19 67.5 6.9 4.3e-06 27.4 0.0 5.3 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15453.1 - 5e-09 36.3 0.1 0.0016 18.7 0.0 3.8 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15453.1 - 4.2e-05 22.4 0.1 0.0007 18.4 0.0 2.0 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO15453.1 - 0.0067 16.7 1.4 0.11 12.9 0.4 2.6 2 0 0 2 2 2 1 Kelch motif DUF4519 PF15012.6 ETO15453.1 - 0.074 13.2 0.0 0.15 12.3 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Herpes_TK_C PF08465.10 ETO15454.1 - 0.013 15.2 0.0 0.026 14.3 0.0 1.5 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal DDE_3 PF13358.6 ETO15455.1 - 4.7e-06 26.4 0.6 1.1e-05 25.2 0.6 1.6 1 1 0 1 1 1 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 ETO15455.1 - 0.00059 20.0 0.4 0.00092 19.4 0.4 1.3 1 0 0 1 1 1 1 Transposase WD40 PF00400.32 ETO15456.1 - 3.4e-28 97.3 17.4 3.2e-07 30.9 1.2 4.7 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15456.1 - 1.2e-08 35.1 0.6 0.035 14.4 0.0 4.2 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15456.1 - 2e-08 33.4 4.6 0.0079 14.9 0.1 4.1 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Peptidase_C14 PF00656.22 ETO15456.1 - 0.0078 16.2 0.1 0.011 15.8 0.1 1.2 1 0 0 1 1 1 1 Caspase domain DUF4777 PF16007.5 ETO15457.1 - 0.059 13.6 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4777) ALMT PF11744.8 ETO15457.1 - 0.098 11.5 7.2 0.12 11.2 7.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Ribosomal_S20p PF01649.18 ETO15457.1 - 0.36 11.5 7.6 0.099 13.3 2.6 2.1 1 1 1 2 2 2 0 Ribosomal protein S20 BRCT_2 PF16589.5 ETO15457.1 - 0.67 10.4 5.8 3.3 8.2 5.8 2.1 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Kelch_1 PF01344.25 ETO15458.1 - 6e-10 38.6 2.2 1.5e-05 24.5 0.5 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO15458.1 - 1.2e-05 25.4 1.0 0.93 9.9 0.2 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO15458.1 - 1.3e-05 25.1 4.9 0.065 13.2 0.5 5.6 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ETO15458.1 - 0.0013 19.0 3.5 0.035 14.4 0.0 4.0 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO15458.1 - 0.0018 18.2 6.8 2 8.5 0.6 4.9 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO15458.1 - 0.043 13.8 3.0 0.5 10.4 0.2 3.6 2 1 1 3 3 3 0 Galactose oxidase, central domain PAP2_C PF14360.6 ETO15460.1 - 0.00091 19.7 0.2 0.00091 19.7 0.2 3.2 4 0 0 4 4 4 1 PAP2 superfamily C-terminal WD40 PF00400.32 ETO15461.1 - 1e-59 197.1 15.8 2.6e-09 37.5 0.2 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15461.1 - 1.1e-16 60.8 1.4 0.0065 16.8 0.0 5.8 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15461.1 - 2.5e-12 46.4 0.2 0.016 14.2 0.0 5.8 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15461.1 - 8.2e-07 28.6 7.8 0.0018 17.7 0.1 3.4 3 1 2 5 5 5 2 WD40-like domain DUF5570 PF17731.1 ETO15461.1 - 3.5e-05 23.9 0.8 13 5.9 0.0 4.8 3 1 2 5 5 5 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO15461.1 - 5.1e-05 22.0 0.4 0.032 12.7 0.0 3.0 1 1 2 4 4 4 3 Cytochrome D1 heme domain TPR_1 PF00515.28 ETO15461.1 - 0.0075 16.0 0.1 0.016 15.1 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO15461.1 - 0.01 16.0 0.2 0.027 14.6 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat PD40 PF07676.12 ETO15461.1 - 0.01 15.7 6.8 6.8 6.8 0.0 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat TPR_2 PF07719.17 ETO15461.1 - 0.12 12.6 0.0 0.24 11.6 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat BBS2_Mid PF14783.6 ETO15461.1 - 0.15 12.1 1.9 16 5.6 0.0 4.4 5 1 0 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Proteasome_A_N PF10584.9 ETO15461.1 - 2.9 7.6 10.0 15 5.3 0.1 4.4 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature CCDC158 PF15921.5 ETO15462.1 - 0.081 10.8 0.4 3.1 5.5 0.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 158 Gti1_Pac2 PF09729.9 ETO15463.1 - 0.002 18.3 8.2 0.002 18.3 8.2 1.8 2 0 0 2 2 2 1 Gti1/Pac2 family Guanylate_cyc PF00211.20 ETO15464.1 - 1.1e-24 87.0 0.7 1.9e-24 86.3 0.7 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain DUF3492 PF11997.8 ETO15468.1 - 0.0024 17.7 0.8 0.0031 17.3 0.8 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3492) Ureide_permease PF07168.11 ETO15468.1 - 0.035 12.9 0.9 0.041 12.6 0.9 1.1 1 0 0 1 1 1 0 Ureide permease TMIE PF16038.5 ETO15468.1 - 8.2 6.3 16.1 1.6 8.6 0.4 2.3 2 1 0 2 2 2 0 TMIE protein Kelch_4 PF13418.6 ETO15469.1 - 3.4e-06 26.9 0.3 0.00042 20.3 0.1 2.4 1 1 1 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO15469.1 - 2.7e-05 23.7 1.8 0.0002 20.8 1.3 2.5 2 1 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO15469.1 - 0.00018 21.7 1.9 0.23 11.8 1.1 3.1 1 1 1 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO15469.1 - 0.00055 19.8 0.3 0.023 14.7 0.3 2.5 2 1 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO15469.1 - 0.02 15.2 0.0 0.16 12.3 0.0 2.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15469.1 - 0.023 14.7 1.2 0.12 12.4 0.4 2.5 3 0 0 3 3 3 0 Kelch motif ATP-grasp_6 PF18419.1 ETO15471.1 - 0.062 12.9 0.0 0.13 11.9 0.0 1.5 1 0 0 1 1 1 0 ATP-grasp-like domain DUF4905 PF16248.5 ETO15471.1 - 0.43 10.5 4.3 1 9.3 0.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4905) ERCC3_RAD25_C PF16203.5 ETO15472.1 - 8.7e-97 323.2 1.0 1.5e-83 279.9 0.1 2.3 2 0 0 2 2 2 2 ERCC3/RAD25/XPB C-terminal helicase Helicase_C_3 PF13625.6 ETO15472.1 - 1.2e-29 103.1 0.0 2.4e-29 102.0 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO15472.1 - 2e-14 53.9 0.0 1.4e-13 51.2 0.0 2.2 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO15472.1 - 2.3e-12 47.2 0.9 8.2e-12 45.4 0.0 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain SNF2_N PF00176.23 ETO15472.1 - 3.8e-08 32.4 1.9 9.6e-08 31.1 1.3 1.8 1 1 1 2 2 2 1 SNF2 family N-terminal domain DEAD PF00270.29 ETO15472.1 - 4.5e-05 23.3 0.0 0.00012 22.0 0.0 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Laminin_G_3 PF13385.6 ETO15473.1 - 2.3e-07 31.1 0.0 6.1e-07 29.7 0.0 1.7 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4704 PF15787.5 ETO15473.1 - 2.6e-07 30.2 2.4 0.0012 18.1 0.0 3.5 2 2 0 2 2 2 2 Domain of unknown function (DUF4704) UPF0262 PF06793.12 ETO15473.1 - 0.079 13.1 0.2 1.5 8.9 0.1 2.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0262) DUF1955 PF09205.10 ETO15474.1 - 0.044 13.5 0.1 0.1 12.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1955) T6PP_N PF18572.1 ETO15474.1 - 0.29 11.0 5.1 2.6 8.0 0.1 3.5 4 0 0 4 4 4 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain TTRAP PF14203.6 ETO15474.1 - 0.36 10.8 2.5 3.6 7.6 0.2 3.1 3 0 0 3 3 3 0 Putative tranposon-transfer assisting protein Baculo_11_kDa PF06143.11 ETO15474.1 - 4.7 6.9 9.9 24 4.6 9.9 2.3 1 0 0 1 1 1 0 Baculovirus 11 kDa family Herpes_UL92 PF03048.14 ETO15475.1 - 0.071 12.9 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 UL92 family Neurokinin_B PF03823.14 ETO15475.1 - 0.24 11.5 1.4 0.65 10.1 0.1 2.5 2 0 0 2 2 2 0 Neurokinin B DUF5517 PF17639.2 ETO15477.1 - 0.1 12.9 1.2 0.2 12.0 0.7 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5517) EspA PF03433.13 ETO15478.1 - 0.015 15.2 3.8 0.3 10.9 3.8 2.0 1 1 0 1 1 1 0 EspA-like secreted protein bZIP_2 PF07716.15 ETO15478.1 - 0.017 15.2 1.0 0.017 15.2 1.0 2.7 2 1 1 3 3 3 0 Basic region leucine zipper Fungal_TACC PF12709.7 ETO15478.1 - 0.18 12.3 16.1 0.93 10.0 2.8 2.3 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins TSC22 PF01166.18 ETO15478.1 - 0.22 11.9 8.2 3.2 8.1 1.0 3.3 1 1 2 3 3 3 0 TSC-22/dip/bun family LAMTOR PF15454.6 ETO15478.1 - 0.3 11.7 3.8 4.9 7.8 0.2 2.3 2 0 0 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator Csm1_N PF18504.1 ETO15478.1 - 0.36 11.2 15.7 1.1 9.6 7.0 2.7 1 1 1 2 2 2 0 Csm1 N-terminal domain CENP-H PF05837.12 ETO15478.1 - 0.68 10.4 10.8 1 9.8 10.8 1.3 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Phage_GPO PF05929.11 ETO15478.1 - 0.94 9.1 8.0 1.1 8.8 8.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DivIC PF04977.15 ETO15478.1 - 1.8 8.4 16.0 4.9 7.0 6.1 2.4 1 1 1 2 2 2 0 Septum formation initiator DUF4407 PF14362.6 ETO15478.1 - 2 7.7 7.6 2.3 7.5 7.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 ETO15478.1 - 3.4 6.8 9.0 3.9 6.6 9.0 1.1 1 0 0 1 1 1 0 TMPIT-like protein DUF4094 PF13334.6 ETO15478.1 - 3.7 8.0 10.2 3.1 8.3 3.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) YabA PF06156.13 ETO15478.1 - 5.5 7.7 12.2 19 6.0 5.1 2.1 1 1 1 2 2 2 0 Initiation control protein YabA ABC_tran_Xtn PF12848.7 ETO15478.1 - 8.6 6.5 13.0 4.6 7.4 7.8 2.1 1 1 1 2 2 2 0 ABC transporter DUF4082 PF13313.6 ETO15480.1 - 0.042 13.9 0.1 0.063 13.3 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4082) DUF4471 PF14740.6 ETO15480.1 - 0.12 11.6 6.4 0.16 11.1 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) TFIIA PF03153.13 ETO15481.1 - 0.00015 21.9 61.7 0.00015 21.9 61.7 4.8 1 1 3 4 4 4 1 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 ETO15482.1 - 6.7e-14 52.1 1.6 6.8e-09 36.2 0.4 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat eIF2A PF08662.11 ETO15482.1 - 0.015 15.2 0.1 0.019 14.9 0.1 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ETO15482.1 - 0.074 13.4 0.1 0.37 11.1 0.1 2.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Velvet PF11754.8 ETO15483.1 - 0.0015 18.5 0.8 0.0015 18.5 0.8 2.4 2 1 0 2 2 2 1 Velvet factor Casc1_N PF15927.5 ETO15485.1 - 1.7e-16 60.5 25.6 1.7e-16 60.5 25.6 2.0 1 1 1 2 2 2 1 Cancer susceptibility candidate 1 N-terminus RisS_PPD PF16524.5 ETO15485.1 - 0.12 12.6 3.3 0.24 11.7 3.3 1.7 1 0 0 1 1 1 0 Periplasmic domain of Sensor histidine kinase RisS TMEM215 PF15746.5 ETO15485.1 - 2.1 7.7 5.7 2.3 7.6 3.3 2.0 2 0 0 2 2 2 0 TMEM215 family ALMT PF11744.8 ETO15485.1 - 3.6 6.3 9.6 7 5.4 9.6 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 ETO15486.1 - 9.3e-06 26.3 2.4 0.033 15.1 0.2 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO15486.1 - 0.094 11.3 0.0 4 6.0 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin Nup120/160 G-alpha PF00503.20 ETO15487.1 - 7.3e-54 183.2 9.2 9.5e-54 182.9 9.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO15487.1 - 1.8e-10 40.6 0.3 4.2e-10 39.4 0.2 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Epimerase PF01370.21 ETO15487.1 - 0.014 14.9 0.1 0.21 11.0 0.0 2.0 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family NYD-SP28 PF14772.6 ETO15488.1 - 0.18 11.8 4.0 0.25 11.4 4.0 1.3 1 0 0 1 1 1 0 Sperm tail PNK3P PF08645.11 ETO15489.1 - 1.3e-43 148.5 2.1 7e-43 146.1 0.8 2.6 2 1 0 2 2 2 1 Polynucleotide kinase 3 phosphatase AAA_33 PF13671.6 ETO15489.1 - 5.2e-14 52.6 0.0 1.3e-11 44.9 0.0 2.5 1 1 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ETO15489.1 - 0.0021 17.4 0.1 0.34 10.1 0.0 2.4 1 1 1 2 2 2 2 Zeta toxin YpsA PF06908.11 ETO15489.1 - 0.022 14.7 0.0 0.074 13.0 0.0 1.8 1 1 0 1 1 1 0 YspA SLOG family PGP_phosphatase PF09419.10 ETO15489.1 - 0.031 13.9 0.2 0.24 11.0 0.0 2.3 2 1 0 2 2 2 0 Mitochondrial PGP phosphatase PP-binding_2 PF14573.6 ETO15489.1 - 0.13 12.5 0.0 0.37 11.0 0.0 1.8 1 0 0 1 1 1 0 Acyl-carrier AAA_16 PF13191.6 ETO15489.1 - 0.17 12.2 0.0 0.41 11.0 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain PUF PF00806.19 ETO15491.1 - 5e-09 35.3 0.6 0.00014 21.3 0.0 2.6 2 0 0 2 2 2 2 Pumilio-family RNA binding repeat Peptidase_S10 PF00450.22 ETO15492.1 - 2.6e-59 201.7 3.5 4.2e-59 201.0 3.5 1.3 1 1 0 1 1 1 1 Serine carboxypeptidase PLA2_inh PF02988.15 ETO15492.1 - 0.015 16.0 2.0 0.026 15.2 2.0 1.3 1 0 0 1 1 1 0 Phospholipase A2 inhibitor dCache_3 PF14827.6 ETO15493.1 - 0.055 13.1 0.1 0.079 12.6 0.1 1.2 1 0 0 1 1 1 0 Double sensory domain of two-component sensor kinase AmiS_UreI PF02293.15 ETO15493.1 - 0.063 13.3 0.5 0.11 12.5 0.5 1.4 1 0 0 1 1 1 0 AmiS/UreI family transporter CTP_transf_1 PF01148.20 ETO15493.1 - 0.12 12.1 2.3 0.16 11.7 2.3 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family Spc7 PF08317.11 ETO15495.1 - 0.00016 20.7 15.5 0.00016 20.7 15.5 3.3 2 1 1 3 3 3 1 Spc7 kinetochore protein Bap31_Bap29_C PF18035.1 ETO15495.1 - 0.0067 16.4 0.6 0.0067 16.4 0.6 5.3 3 2 2 5 5 5 1 Bap31/Bap29 cytoplasmic coiled-coil domain PGA_cap PF09587.10 ETO15495.1 - 0.24 10.8 3.4 0.19 11.2 0.6 2.0 2 0 0 2 2 2 0 Bacterial capsule synthesis protein PGA_cap ApoO PF09769.9 ETO15495.1 - 0.37 10.7 2.9 17 5.4 0.1 2.9 2 0 0 2 2 2 0 Apolipoprotein O Lectin_N PF03954.14 ETO15495.1 - 0.81 9.4 8.9 5.7 6.7 1.1 3.1 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain Nup54 PF13874.6 ETO15495.1 - 3.4 7.8 24.9 30 4.7 11.1 4.2 2 2 0 2 2 2 0 Nucleoporin complex subunit 54 CPG4 PF15481.6 ETO15495.1 - 5.5 7.7 8.5 1.3 9.7 1.4 3.2 3 0 0 3 3 3 0 Chondroitin proteoglycan 4 TRAF_BIRC3_bd PF16673.5 ETO15495.1 - 6.1 6.7 11.3 3.7 7.4 0.1 4.5 4 0 0 4 4 4 0 TNF receptor-associated factor BIRC3 binding domain WXG100 PF06013.12 ETO15495.1 - 6.2 7.1 10.5 2.5 8.4 0.1 4.3 4 1 0 4 4 4 0 Proteins of 100 residues with WXG SHE3 PF17078.5 ETO15495.1 - 7.9 6.1 44.4 0.22 11.2 12.1 3.7 2 1 2 4 4 4 0 SWI5-dependent HO expression protein 3 Nup188_C PF18378.1 ETO15496.1 - 0.1 11.4 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain Phytochelatin PF05023.14 ETO15497.1 - 0.11 11.8 2.4 0.25 10.5 2.4 1.6 1 1 0 1 1 1 0 Phytochelatin synthase Aldo_ket_red PF00248.21 ETO15498.1 - 5.2e-25 88.2 0.0 4.7e-18 65.4 0.0 2.2 2 0 0 2 2 2 2 Aldo/keto reductase family zf-WRNIP1_ubi PF18279.1 ETO15499.1 - 0.097 13.4 0.0 0.2 12.4 0.0 1.5 1 0 0 1 1 1 0 Werner helicase-interacting protein 1 ubiquitin-binding domain UNC-93 PF05978.16 ETO15500.1 - 7.2e-13 48.5 12.7 9.9e-13 48.1 11.2 2.1 1 1 0 1 1 1 1 Ion channel regulatory protein UNC-93 TerC PF03741.16 ETO15500.1 - 0.041 13.6 0.4 0.073 12.8 0.3 1.5 1 1 0 1 1 1 0 Integral membrane protein TerC family Radical_SAM PF04055.21 ETO15501.1 - 1.3e-20 74.4 0.5 2.5e-20 73.5 0.5 1.5 1 0 0 1 1 1 1 Radical SAM superfamily Ferrochelatase PF00762.19 ETO15501.1 - 0.11 11.5 0.0 0.67 9.0 0.0 1.9 1 1 1 2 2 2 0 Ferrochelatase CTP_transf_1 PF01148.20 ETO15502.1 - 1.3e-66 225.1 18.2 1.8e-66 224.6 18.2 1.2 1 0 0 1 1 1 1 Cytidylyltransferase family Lipase_3 PF01764.25 ETO15503.1 - 2.8e-11 43.5 0.0 6.3e-11 42.3 0.0 1.6 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ETO15503.1 - 0.0019 17.8 0.0 0.004 16.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Thioesterase PF00975.20 ETO15503.1 - 0.0032 17.6 0.0 0.0057 16.8 0.0 1.3 1 0 0 1 1 1 1 Thioesterase domain PGAP1 PF07819.13 ETO15503.1 - 0.0032 17.2 0.0 0.0067 16.2 0.0 1.5 1 0 0 1 1 1 1 PGAP1-like protein Abhydrolase_6 PF12697.7 ETO15503.1 - 0.0049 17.5 0.0 0.01 16.4 0.0 1.5 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ETO15503.1 - 0.016 14.9 0.0 0.03 14.0 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 ETO15503.1 - 0.04 13.2 0.0 0.11 11.7 0.0 1.7 2 0 0 2 2 2 0 Serine aminopeptidase, S33 DUF676 PF05057.14 ETO15503.1 - 0.052 13.0 0.0 0.09 12.3 0.0 1.3 1 0 0 1 1 1 0 Putative serine esterase (DUF676) UPF0227 PF05728.12 ETO15503.1 - 0.061 13.3 0.2 0.67 9.9 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0227) Fer4_17 PF13534.6 ETO15504.1 - 0.053 14.1 1.7 0.053 14.1 1.7 2.8 2 2 1 3 3 3 0 4Fe-4S dicluster domain eRF1_3 PF03465.15 ETO15505.1 - 0.0016 18.9 0.2 0.034 14.6 0.2 2.4 1 1 0 1 1 1 1 eRF1 domain 3 NIF PF03031.18 ETO15506.1 - 2.5e-22 79.3 0.1 3.5e-22 78.8 0.1 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase SCAI PF12070.8 ETO15506.1 - 0.018 13.9 3.2 0.024 13.6 3.2 1.2 1 0 0 1 1 1 0 Protein SCAI Tim54 PF11711.8 ETO15506.1 - 0.039 12.7 2.9 0.045 12.6 2.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HAD PF12710.7 ETO15506.1 - 0.19 12.1 0.0 0.27 11.6 0.0 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase AIF_C PF14721.6 ETO15506.1 - 0.21 11.9 3.4 0.31 11.4 3.4 1.2 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RbsD_FucU PF05025.13 ETO15506.1 - 0.24 11.8 1.3 0.39 11.1 0.0 1.8 2 0 0 2 2 2 0 RbsD / FucU transport protein family TFIIA PF03153.13 ETO15506.1 - 0.57 10.1 20.1 0.59 10.1 20.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ATAD4 PF15321.6 ETO15506.1 - 2.4 9.5 8.4 9.3 7.7 0.1 2.2 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 Presenilin PF01080.17 ETO15506.1 - 2.5 6.8 5.5 2.7 6.7 5.5 1.1 1 0 0 1 1 1 0 Presenilin TERB2 PF15101.6 ETO15506.1 - 5.5 7.0 10.9 7 6.6 10.9 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 PAT1 PF09770.9 ETO15506.1 - 9.3 4.4 15.7 9.9 4.3 15.7 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Prok-JAB PF14464.6 ETO15507.1 - 5.8e-11 42.2 1.1 1.4e-10 41.0 1.1 1.6 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain JAB PF01398.21 ETO15507.1 - 2.7e-10 40.2 2.3 3.7e-10 39.8 0.2 2.3 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Myb_DNA-binding PF00249.31 ETO15507.1 - 2.5e-08 34.0 0.0 5.5e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain UPF0172 PF03665.13 ETO15507.1 - 0.00045 20.3 0.2 0.00045 20.3 0.2 2.4 3 0 0 3 3 3 1 Uncharacterised protein family (UPF0172) Myb_DNA-bind_7 PF15963.5 ETO15507.1 - 0.0016 18.3 0.2 0.0016 18.3 0.2 2.5 2 0 0 2 2 2 1 Myb DNA-binding like Myb_DNA-bind_6 PF13921.6 ETO15507.1 - 0.003 17.8 0.1 0.01 16.0 0.1 2.0 1 0 0 1 1 1 1 Myb-like DNA-binding domain ComS PF17584.2 ETO15508.1 - 0.071 12.6 0.0 0.14 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacillus competence protein S BsuBI_PstI_RE PF06616.11 ETO15509.1 - 0.02 14.2 0.1 0.077 12.3 0.1 1.9 2 0 0 2 2 2 0 BsuBI/PstI restriction endonuclease domain CNOT11 PF10155.9 ETO15509.1 - 0.025 14.7 1.8 0.62 10.2 1.8 2.4 1 1 0 1 1 1 0 CCR4-NOT transcription complex subunit 11 AP3D1 PF06375.11 ETO15509.1 - 0.13 12.5 1.3 0.2 11.9 1.3 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 WD40 PF00400.32 ETO15510.1 - 2.3e-18 66.2 4.3 9.8e-06 26.2 0.2 4.5 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15510.1 - 7.1e-06 26.2 0.2 2.6 8.4 0.0 3.3 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15510.1 - 0.00013 20.8 0.0 0.59 8.7 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 TPR_12 PF13424.6 ETO15512.1 - 2.7e-63 210.2 11.3 2.8e-17 62.8 0.1 5.7 3 2 3 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO15512.1 - 3.7e-45 150.6 5.1 2e-09 37.0 0.0 6.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO15512.1 - 8.8e-38 126.6 30.1 5.7e-08 32.2 0.0 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO15512.1 - 1e-29 100.4 5.8 9.2e-06 25.3 0.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO15512.1 - 2.3e-29 99.1 22.1 9.1e-06 25.4 0.5 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO15512.1 - 1.9e-28 96.2 24.0 4.5e-06 26.5 0.1 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO15512.1 - 2.1e-12 46.5 29.6 0.0058 16.3 0.0 9.6 7 3 3 10 10 10 3 TPR repeat TPR_17 PF13431.6 ETO15512.1 - 3e-10 39.7 9.1 0.6 10.6 0.1 6.6 6 1 0 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO15512.1 - 1.6e-08 34.7 0.0 14 6.8 0.0 6.8 6 1 1 7 7 7 0 Tetratricopeptide repeat MIT PF04212.18 ETO15512.1 - 2.7e-08 33.7 9.0 1.1 9.4 0.0 6.3 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO15512.1 - 1.1e-07 32.0 7.7 12 6.8 0.0 6.4 6 0 0 6 6 6 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO15512.1 - 1.8e-06 27.3 2.7 0.73 9.3 0.1 5.7 6 0 0 6 6 6 2 SHNi-TPR DUF5113 PF17140.4 ETO15512.1 - 9.7e-06 25.5 14.4 0.15 11.9 0.7 5.6 5 1 1 6 6 6 2 Domain of unknown function (DUF5113) DUF2225 PF09986.9 ETO15512.1 - 1.8e-05 24.6 7.3 0.54 9.9 0.4 3.5 2 1 1 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) TPR_16 PF13432.6 ETO15512.1 - 0.0002 21.9 2.3 14 6.4 0.0 5.4 5 1 1 6 6 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO15512.1 - 0.0014 18.1 0.0 0.087 12.2 0.0 2.5 2 1 0 2 2 2 1 MalT-like TPR region DUF3856 PF12968.7 ETO15512.1 - 0.0073 16.4 4.2 7 6.7 0.0 4.5 2 2 2 4 4 4 1 Domain of Unknown Function (DUF3856) HTH_Bact PF18768.1 ETO15512.1 - 0.012 15.2 0.6 5.9 6.5 0.0 3.9 3 0 0 3 3 2 0 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO15512.1 - 0.022 14.7 2.9 0.32 11.0 0.1 3.3 4 0 0 4 4 4 0 Protein of unknown function (DUF627) TPR_3 PF07720.12 ETO15512.1 - 0.14 12.1 13.9 3.2 7.9 0.0 5.4 5 0 0 5 5 5 0 Tetratricopeptide repeat OEP PF02321.18 ETO15512.1 - 0.9 9.3 3.2 7.2 6.4 1.3 3.1 3 1 1 4 4 4 0 Outer membrane efflux protein NSF PF02071.20 ETO15512.1 - 9.4 7.5 11.4 1.3e+02 4.2 0.6 5.5 5 0 0 5 5 4 0 Aromatic-di-Alanine (AdAR) repeat A_deamin PF02137.18 ETO15513.1 - 0.063 12.7 0.1 0.063 12.7 0.1 1.0 1 0 0 1 1 1 0 Adenosine-deaminase (editase) domain UFD1 PF03152.14 ETO15515.1 - 3.2e-41 140.7 0.0 3.5e-41 140.5 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 SR-25 PF10500.9 ETO15516.1 - 0.21 11.2 5.0 0.27 10.8 5.0 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein WD40 PF00400.32 ETO15519.1 - 2.7e-36 122.9 25.9 5.7e-07 30.1 0.5 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15519.1 - 7e-11 42.3 3.4 0.2 12.0 0.1 5.2 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15519.1 - 2.3e-10 39.8 8.9 0.073 11.7 0.5 5.3 2 2 1 5 5 5 5 Nucleoporin Nup120/160 USP7_C2 PF14533.6 ETO15519.1 - 0.024 14.3 0.6 6 6.5 0.0 2.7 2 1 0 2 2 2 0 Ubiquitin-specific protease C-terminal DUF1481 PF07356.12 ETO15519.1 - 0.06 13.1 0.5 0.99 9.1 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1481) Exo_endo_phos PF03372.23 ETO15520.1 - 0.0041 16.7 0.0 0.0082 15.7 0.0 2.0 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1349 PF07081.11 ETO15521.1 - 2.3e-62 209.9 0.1 2.6e-62 209.7 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1349) Fungal_KA1 PF16797.5 ETO15521.1 - 0.056 13.1 0.0 0.088 12.5 0.0 1.3 1 0 0 1 1 1 0 Fungal kinase associated-1 domain SprA-related PF12118.8 ETO15522.1 - 0.26 10.4 30.7 0.46 9.6 30.7 1.4 1 0 0 1 1 1 0 SprA-related family Spore_coat_CotO PF14153.6 ETO15522.1 - 0.41 10.6 23.6 7.2 6.5 21.7 2.6 2 0 0 2 2 2 0 Spore coat protein CotO GREB1 PF15782.5 ETO15522.1 - 1.2 6.1 23.8 1.8 5.6 23.8 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Podoplanin PF05808.11 ETO15522.1 - 4.6 7.3 7.5 9 6.4 7.5 1.5 1 0 0 1 1 1 0 Podoplanin TFIIA PF03153.13 ETO15522.1 - 6.1 6.7 51.4 14 5.5 51.4 1.5 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AAA_23 PF13476.6 ETO15522.1 - 6.3 7.3 30.7 0.36 11.3 21.7 2.4 2 0 0 2 2 2 0 AAA domain RR_TM4-6 PF06459.12 ETO15522.1 - 8.6 6.1 27.7 0.88 9.3 22.8 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RR_TM4-6 PF06459.12 ETO15523.1 - 0.7 9.7 10.0 0.89 9.3 10.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Membralin PF09746.9 ETO15523.1 - 3.3 6.7 5.5 3.5 6.6 5.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO15523.1 - 8 5.1 11.8 9.3 4.9 11.8 1.1 1 0 0 1 1 1 0 Presenilin CAP_GLY PF01302.25 ETO15527.1 - 0.0085 16.1 0.0 0.024 14.6 0.0 1.7 1 0 0 1 1 1 1 CAP-Gly domain Mab-21 PF03281.14 ETO15527.1 - 0.024 13.9 0.0 0.036 13.4 0.0 1.3 1 0 0 1 1 1 0 Mab-21 protein Pkinase PF00069.25 ETO15528.1 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO15529.1 - 2.6e-52 177.8 0.2 3.3e-52 177.5 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15529.1 - 5e-36 124.3 0.1 6.1e-36 124.0 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO15529.1 - 1.1e-07 31.5 0.0 2e-07 30.6 0.0 1.3 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO15529.1 - 1.8e-06 27.5 0.7 1.8e-06 27.5 0.7 1.5 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO15529.1 - 0.0001 22.3 0.1 0.00015 21.8 0.1 1.1 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO15529.1 - 0.0007 18.6 0.9 0.00091 18.3 0.9 1.1 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ETO15529.1 - 0.0022 17.6 0.2 0.0028 17.3 0.2 1.1 1 0 0 1 1 1 1 RIO1 family Choline_kinase PF01633.20 ETO15529.1 - 0.012 15.2 0.7 0.02 14.5 0.2 1.7 1 1 1 2 2 2 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ETO15529.1 - 0.037 12.8 0.0 0.063 12.0 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase YukC PF10140.9 ETO15529.1 - 0.1 11.4 0.1 0.13 11.0 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukC Kelch_1 PF01344.25 ETO15531.1 - 1.7e-08 33.9 7.5 5.5e-07 29.1 0.2 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO15531.1 - 1.8e-07 31.2 5.9 0.0038 17.5 0.1 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO15531.1 - 2.7e-05 24.1 7.5 0.0002 21.3 0.1 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15531.1 - 7.3e-05 22.7 4.1 0.17 11.9 0.1 3.4 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO15531.1 - 0.0002 21.5 2.3 0.12 12.7 0.0 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO15531.1 - 0.0093 15.9 3.2 0.51 10.4 0.1 3.9 4 0 0 4 4 4 1 Kelch motif fn3 PF00041.21 ETO15532.1 - 0.012 15.9 1.4 0.022 15.1 0.1 2.0 2 0 0 2 2 2 0 Fibronectin type III domain WD40 PF00400.32 ETO15533.1 - 3.5e-36 122.6 17.4 1.6e-06 28.7 1.4 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO15533.1 - 8.4e-14 51.1 5.8 0.086 11.5 0.1 5.9 1 1 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15533.1 - 3.9e-12 46.3 0.2 0.026 14.8 0.0 6.0 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain LDB19 PF13002.7 ETO15533.1 - 0.93 9.2 3.6 11 5.7 0.0 3.0 2 1 1 3 3 3 0 Arrestin_N terminal like ABC_tran PF00005.27 ETO15534.1 - 3.9e-17 63.1 0.0 6.3e-17 62.4 0.0 1.3 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO15534.1 - 5.9e-05 23.0 0.0 6.9e-05 22.8 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO15534.1 - 0.0017 17.9 0.0 0.002 17.6 0.0 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO15534.1 - 0.01 16.1 0.2 0.21 11.8 0.2 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit KDGP_aldolase PF07071.11 ETO15534.1 - 0.1 12.4 0.0 0.13 12.0 0.0 1.1 1 0 0 1 1 1 0 KDGP aldolase WD40 PF00400.32 ETO15535.1 - 1.6e-19 69.8 5.9 7.3e-07 29.8 0.3 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15535.1 - 8e-09 35.7 1.5 0.083 13.2 0.1 3.6 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO15535.1 - 2.3e-08 34.2 0.8 0.00069 19.5 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO15535.1 - 4.5e-05 22.3 1.7 0.12 11.0 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO15535.1 - 8e-05 21.8 1.2 0.33 9.9 0.0 3.4 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO15535.1 - 0.0014 18.5 0.3 0.31 11.0 0.0 2.5 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO15535.1 - 0.13 11.9 0.0 13 5.5 0.0 2.6 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Nucleoporin_N PF08801.11 ETO15535.1 - 0.2 10.4 6.0 0.42 9.3 0.3 2.7 1 1 2 3 3 3 0 Nup133 N terminal like WD40 PF00400.32 ETO15537.1 - 1.4e-06 28.9 0.7 1.9e-05 25.3 0.1 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat FG-GAP PF01839.23 ETO15538.1 - 7.2e-09 35.6 10.0 4.2e-05 23.6 0.0 3.3 3 0 0 3 3 3 2 FG-GAP repeat VCBS PF13517.6 ETO15538.1 - 0.17 12.5 0.1 0.17 12.5 0.1 3.6 3 3 0 3 3 3 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DUF737 PF05300.11 ETO15539.1 - 0.0011 19.3 16.4 0.0013 19.1 16.4 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF737) SID-1_RNA_chan PF13965.6 ETO15539.1 - 0.0059 15.1 2.9 0.0068 14.9 2.9 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 CNDH2_C PF16858.5 ETO15539.1 - 0.01 15.7 18.3 0.012 15.5 18.3 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Apt1 PF10351.9 ETO15539.1 - 0.016 14.1 12.4 0.02 13.8 12.4 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SpoIIIAH PF12685.7 ETO15539.1 - 0.019 14.8 11.5 0.027 14.3 11.5 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Neur_chan_memb PF02932.16 ETO15539.1 - 0.079 13.0 10.7 0.099 12.7 10.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 ETO15539.1 - 0.12 10.4 15.8 0.14 10.2 15.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO15539.1 - 0.18 10.5 18.0 0.22 10.2 18.0 1.3 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 ETO15539.1 - 0.3 11.1 26.9 0.37 10.7 26.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF913 PF06025.12 ETO15539.1 - 1.1 8.1 11.3 1.5 7.7 11.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO15539.1 - 1.9 7.6 17.7 2.8 7.0 17.7 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter Cwf_Cwc_15 PF04889.12 ETO15539.1 - 2.4 7.8 28.8 3.3 7.4 28.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Ctr PF04145.15 ETO15539.1 - 7 7.3 11.6 69 4.0 11.6 2.1 1 1 0 1 1 1 0 Ctr copper transporter family DUF4661 PF15576.6 ETO15539.1 - 8.2 6.3 11.7 11 5.9 11.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Sec20 PF03908.13 ETO15540.1 - 0.0047 16.8 3.5 0.006 16.5 3.5 1.1 1 0 0 1 1 1 1 Sec20 Pex24p PF06398.11 ETO15540.1 - 0.04 12.9 1.5 0.044 12.8 1.5 1.0 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin KCT2 PF17818.1 ETO15540.1 - 0.53 10.4 3.2 0.52 10.4 2.6 1.3 1 1 0 1 1 1 0 Keratinocyte-associated gene product Kelch_6 PF13964.6 ETO15541.1 - 0.0023 18.2 0.1 0.02 15.2 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO15541.1 - 0.01 15.8 0.5 6.8 6.8 0.1 2.8 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO15541.1 - 0.032 13.8 0.7 1.5 8.5 0.0 3.2 3 1 0 3 3 3 0 Kelch motif AnmK PF03702.14 ETO15541.1 - 0.07 12.2 0.0 0.5 9.4 0.0 2.1 2 0 0 2 2 2 0 Anhydro-N-acetylmuramic acid kinase Kelch_2 PF07646.15 ETO15541.1 - 0.16 12.0 0.3 3.7 7.7 0.0 3.0 3 1 0 3 3 3 0 Kelch motif DUF2981 PF11200.8 ETO15542.1 - 0.14 11.8 5.4 0.19 11.4 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Peptidase_C14 PF00656.22 ETO15543.1 - 1.5e-08 34.9 4.0 1.5e-08 34.9 4.0 2.7 2 1 0 2 2 2 1 Caspase domain Kelch_2 PF07646.15 ETO15543.1 - 0.0002 21.2 2.3 0.011 15.7 0.2 4.0 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO15543.1 - 0.00052 19.9 2.9 0.53 10.3 0.4 3.9 3 1 1 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO15543.1 - 0.0025 17.8 0.1 0.015 15.3 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO15543.1 - 0.056 13.8 1.1 3.2 8.2 0.1 3.6 4 0 0 4 4 4 0 Kelch motif Sec20 PF03908.13 ETO15543.1 - 0.058 13.3 0.1 0.61 10.0 0.0 2.8 2 0 0 2 2 2 0 Sec20 Kelch_1 PF01344.25 ETO15543.1 - 0.2 11.3 0.2 1.1 8.9 0.1 2.2 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO15544.1 - 8.2e-33 111.9 29.1 1.4e-06 28.9 0.8 7.0 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15544.1 - 3.6e-11 43.2 5.1 0.17 12.2 0.0 6.0 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15544.1 - 1.4e-07 31.1 7.6 0.1 11.9 0.3 5.1 2 2 3 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO15544.1 - 3.1e-07 29.4 5.5 0.029 13.0 0.2 4.1 1 1 4 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO15544.1 - 0.1 12.7 0.7 32 4.6 0.0 4.0 2 1 2 4 4 4 0 Ciliary BBSome complex subunit 2, middle region DUF5570 PF17731.1 ETO15544.1 - 0.49 10.5 5.0 1.1 9.3 0.4 2.9 3 1 0 3 3 3 0 Family of unknown function (DUF5570) Pkinase PF00069.25 ETO15545.1 - 1.9e-07 30.7 0.0 4.1e-07 29.6 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Cnn_1N PF07989.11 ETO15546.1 - 0.027 14.6 1.5 0.052 13.7 1.5 1.5 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 PSS PF03034.15 ETO15547.1 - 3.7e-77 259.8 27.8 2.8e-45 155.2 7.6 3.5 3 1 1 4 4 4 3 Phosphatidyl serine synthase Peptidase_M16_C PF05193.21 ETO15548.1 - 2.6e-07 30.9 0.0 2.9e-07 30.7 0.0 1.0 1 0 0 1 1 1 1 Peptidase M16 inactive domain tRNA_deacylase PF04414.12 ETO15549.1 - 0.21 11.1 0.5 0.63 9.5 0.2 1.9 2 0 0 2 2 2 0 D-aminoacyl-tRNA deacylase WD40 PF00400.32 ETO15550.1 - 4e-39 131.9 30.8 7.6e-08 32.9 0.4 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15550.1 - 4.3e-12 46.2 2.5 0.0076 16.5 0.0 5.7 2 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15550.1 - 2.7e-08 33.0 6.3 0.74 8.4 0.1 5.6 3 3 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15550.1 - 4.7e-05 22.9 4.4 0.42 9.9 0.1 4.2 2 2 2 5 5 5 3 WD40-like domain PV-1 PF06637.11 ETO15552.1 - 0.0076 15.1 5.4 0.0097 14.8 5.4 1.2 1 0 0 1 1 1 1 PV-1 protein (PLVAP) DUF5128 PF17170.4 ETO15556.1 - 0.00064 19.0 1.7 0.0011 18.2 0.3 1.8 2 0 0 2 2 2 1 6-bladed beta-propeller Gemini_AL1 PF00799.20 ETO15557.1 - 6.7e-19 68.3 1.2 6.7e-19 68.3 1.2 2.4 2 0 0 2 2 2 1 Geminivirus Rep catalytic domain Viral_Rep PF02407.16 ETO15557.1 - 0.13 12.5 1.4 0.4 11.0 0.1 2.5 3 0 0 3 3 3 0 Putative viral replication protein Kelch_1 PF01344.25 ETO15558.1 - 0.0013 18.3 1.1 0.0039 16.7 0.3 2.3 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO15558.1 - 0.0037 17.5 0.1 0.014 15.7 0.1 2.0 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15558.1 - 0.044 13.8 0.3 1.2 9.1 0.2 3.3 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO15558.1 - 0.1 12.6 11.4 0.2 11.7 0.4 4.7 5 2 1 6 6 6 0 Kelch motif Kelch_6 PF13964.6 ETO15558.1 - 0.19 12.1 0.7 17 5.9 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO15559.1 - 1.4e-05 25.2 7.1 0.056 13.8 0.0 4.2 3 1 1 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO15559.1 - 0.0022 17.6 3.3 0.21 11.2 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO15559.1 - 0.044 13.8 4.5 4.6 7.4 0.1 3.7 4 0 0 4 4 4 0 Kelch motif N_Asn_amidohyd PF14736.6 ETO15559.1 - 0.053 12.7 0.1 0.49 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_5 PF13854.6 ETO15559.1 - 0.067 13.2 8.0 3.7 7.7 0.0 4.1 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO15560.1 - 1.3e-35 120.8 30.9 1.8e-07 31.7 2.1 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15560.1 - 1.1e-12 48.0 7.2 0.0035 17.6 0.0 5.4 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15560.1 - 0.00018 20.3 8.7 0.65 8.6 0.2 4.4 1 1 3 5 5 5 3 Nucleoporin Nup120/160 zf-RING_11 PF17123.5 ETO15560.1 - 0.058 13.2 0.0 0.28 11.0 0.0 2.2 1 0 0 1 1 1 0 RING-like zinc finger WD40 PF00400.32 ETO15561.1 - 4.2e-57 188.8 19.2 2.9e-09 37.4 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15561.1 - 9.6e-26 89.9 1.9 2.1e-05 24.7 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15561.1 - 2.4e-15 56.3 1.1 0.0032 16.5 0.0 5.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15561.1 - 7.6e-14 51.7 4.0 0.00037 19.9 0.0 4.2 3 1 1 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO15561.1 - 2.6e-11 42.9 3.2 0.27 9.8 0.0 5.7 1 1 5 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO15561.1 - 2.2e-06 27.4 6.4 3.5 7.7 0.1 4.9 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO15561.1 - 1.3e-05 25.3 0.5 2.8 8.1 0.0 4.2 2 1 1 4 4 4 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO15561.1 - 0.00017 20.2 0.0 0.093 11.2 0.0 2.4 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO15561.1 - 0.0028 17.0 1.5 2 7.7 0.1 4.1 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO15561.1 - 0.0033 17.1 0.0 0.3 10.6 0.0 2.5 1 1 0 1 1 1 1 PQQ-like domain PALB2_WD40 PF16756.5 ETO15561.1 - 0.0035 16.3 6.6 2.5 6.9 0.0 4.2 2 2 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 ETO15561.1 - 0.013 15.4 0.0 21 5.2 0.0 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat nos_propeller PF18764.1 ETO15561.1 - 0.036 14.0 0.0 37 4.3 0.0 4.2 6 0 0 6 6 6 0 Nitrous oxide reductase propeller repeat DUF5449 PF17528.2 ETO15561.1 - 0.081 12.7 0.7 6 6.6 0.2 2.8 3 1 0 3 3 3 0 Family of unknown function (DUF5449) DUF1797 PF08796.10 ETO15561.1 - 0.11 12.6 0.0 1.9 8.6 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) SBD PF17882.1 ETO15561.1 - 0.14 12.0 0.2 29 4.5 0.0 3.4 1 1 3 4 4 4 0 OAA-family lectin sugar binding domain WD40 PF00400.32 ETO15563.1 - 7.8e-31 105.7 11.4 6.1e-07 30.0 0.4 6.3 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15563.1 - 2.4e-10 40.6 1.2 0.0021 18.3 0.0 4.8 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15563.1 - 1.5e-07 30.4 1.1 0.75 8.4 0.0 4.7 3 2 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15563.1 - 2e-05 24.1 1.0 0.11 11.8 0.0 3.4 2 2 1 3 3 3 2 WD40-like domain BBS2_Mid PF14783.6 ETO15563.1 - 0.00039 20.4 3.4 0.076 13.0 0.2 3.9 2 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region HARP PF07443.13 ETO15563.1 - 0.0058 16.2 0.0 3.4 7.4 0.0 3.1 3 0 0 3 3 3 2 HepA-related protein (HARP) PurA PF04845.13 ETO15564.1 - 0.04 13.2 0.0 0.044 13.1 0.0 1.1 1 0 0 1 1 1 0 PurA ssDNA and RNA-binding protein YcgL PF05166.13 ETO15564.1 - 0.077 13.4 0.1 0.23 11.9 0.0 1.7 2 1 0 2 2 2 0 YcgL domain TERB2 PF15101.6 ETO15565.1 - 0.0023 18.0 2.7 0.0033 17.5 2.7 1.3 1 0 0 1 1 1 1 Telomere-associated protein TERB2 Presenilin PF01080.17 ETO15565.1 - 0.13 11.0 0.5 0.12 11.1 0.5 1.2 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 ETO15565.1 - 3.4 7.1 7.4 5.3 6.5 7.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 YycC PF14174.6 ETO15567.1 - 0.0096 15.7 0.6 0.023 14.5 0.6 1.6 1 0 0 1 1 1 1 YycC-like protein WD40 PF00400.32 ETO15568.1 - 1.1e-37 127.3 35.8 2.6e-07 31.2 2.8 7.9 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15568.1 - 2.6e-10 40.5 2.3 0.025 14.9 0.0 5.1 2 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15568.1 - 1.9e-08 33.4 7.7 0.017 13.8 0.4 5.4 2 2 3 6 6 6 5 Nucleoporin Nup120/160 W_rich_C PF07483.11 ETO15568.1 - 7.7 6.7 12.6 2.2 8.5 0.4 3.8 3 1 1 4 4 4 0 Tryptophan-rich Synechocystis species C-terminal domain WD40 PF00400.32 ETO15569.1 - 1.1e-12 48.2 1.2 2.4e-07 31.3 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO15569.1 - 0.0058 15.3 0.2 0.85 8.2 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15569.1 - 0.14 11.5 10.0 0.53 9.6 9.9 2.0 1 1 0 1 1 1 0 WD40-like domain WD40 PF00400.32 ETO15570.1 - 2.9e-10 40.6 6.7 0.024 15.5 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15570.1 - 3.4e-07 30.5 0.1 0.47 10.8 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15570.1 - 0.015 14.0 0.3 1.6 7.3 0.2 2.1 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Resistin PF06954.11 ETO15571.1 - 0.034 14.7 0.2 0.094 13.3 0.2 1.7 1 0 0 1 1 1 0 Resistin RRM_1 PF00076.22 ETO15572.1 - 3.2e-10 39.7 0.1 5.4e-10 38.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ferlin_C PF16165.5 ETO15572.1 - 2.3 8.1 10.2 2.2 8.2 2.2 2.1 2 0 0 2 2 2 0 Ferlin C-terminus Pkinase PF00069.25 ETO15573.1 - 1.1e-27 97.1 1.1 3e-27 95.7 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15573.1 - 2.1e-11 43.6 0.1 4e-11 42.7 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Seryl_tRNA_N PF02403.22 ETO15573.1 - 0.88 9.8 8.8 1.6 9.0 8.8 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FapA PF03961.13 ETO15573.1 - 3.6 6.1 6.3 4.5 5.8 6.3 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A BUD22 PF09073.10 ETO15577.1 - 0.8 9.0 26.9 1 8.6 26.9 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETO15577.1 - 0.84 7.9 19.9 1.2 7.4 19.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Peptidase_S64 PF08192.11 ETO15577.1 - 5.3 5.4 11.0 6.9 5.0 11.0 1.2 1 0 0 1 1 1 0 Peptidase family S64 EF-hand_1 PF00036.32 ETO15579.1 - 6.3e-07 28.5 0.1 1e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO15579.1 - 1.6e-05 24.4 0.1 3.1e-05 23.5 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ETO15579.1 - 3e-05 23.3 0.1 4.8e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO15579.1 - 6.4e-05 23.3 0.1 9.1e-05 22.8 0.1 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ETO15579.1 - 6.9e-05 22.6 0.4 0.0029 17.4 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair Caleosin PF05042.13 ETO15579.1 - 0.033 14.1 0.0 0.046 13.6 0.0 1.3 1 0 0 1 1 1 0 Caleosin related protein EF-hand_5 PF13202.6 ETO15580.1 - 0.002 17.5 0.7 0.0054 16.2 0.7 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO15580.1 - 0.0047 17.3 0.5 0.01 16.2 0.6 1.7 1 1 0 1 1 1 1 EF-hand domain pair YMF19 PF02326.15 ETO15580.1 - 0.18 12.6 10.7 0.13 13.1 7.9 2.1 2 0 0 2 2 2 0 Plant ATP synthase F0 EVC2_like PF12297.8 ETO15580.1 - 3.8 6.1 6.1 0.88 8.2 2.9 1.5 2 0 0 2 2 2 0 Ellis van Creveld protein 2 like protein Kelch_6 PF13964.6 ETO15581.1 - 4.1e-09 36.4 1.2 2.9e-05 24.2 0.0 4.2 3 1 1 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO15581.1 - 7.9e-06 25.7 3.6 0.28 11.2 0.0 4.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO15581.1 - 5.8e-05 22.6 2.2 0.024 14.2 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO15581.1 - 0.11 12.5 4.0 32 4.6 0.0 4.1 4 1 0 4 4 4 0 Galactose oxidase, central domain DUF2547 PF10818.8 ETO15581.1 - 0.18 12.8 2.6 0.78 10.7 1.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2547) Kelch_3 PF13415.6 ETO15581.1 - 0.29 11.5 7.5 20 5.6 0.1 4.8 4 1 0 4 4 4 0 Galactose oxidase, central domain zf-TRAF PF02176.18 ETO15582.1 - 3.1e-08 34.2 3.1 3.1e-08 34.2 3.1 3.4 2 1 1 3 3 3 2 TRAF-type zinc finger Glyco_hydro_65m PF03632.15 ETO15584.1 - 8.2e-40 136.8 10.7 1.6e-38 132.6 0.2 2.6 3 0 0 3 3 3 2 Glycosyl hydrolase family 65 central catalytic domain B12D PF06522.11 ETO15584.1 - 0.12 12.2 0.0 0.29 11.0 0.0 1.5 1 0 0 1 1 1 0 NADH-ubiquinone reductase complex 1 MLRQ subunit RNase_H PF00075.24 ETO15585.1 - 3.4e-10 40.3 0.6 3.4e-10 40.3 0.6 1.9 2 0 0 2 2 2 1 RNase H BRE PF06113.12 ETO15585.1 - 0.0049 15.8 0.4 0.44 9.3 0.1 2.1 1 1 1 2 2 2 2 Brain and reproductive organ-expressed protein (BRE) LpxI_N PF17930.1 ETO15585.1 - 0.065 13.1 0.0 0.14 12.0 0.0 1.5 1 0 0 1 1 1 0 LpxI N-terminal domain TCL1_MTCP1 PF01840.17 ETO15586.1 - 0.52 10.0 3.6 0.62 9.7 1.4 2.1 1 1 0 2 2 2 0 TCL1/MTCP1 family FidL_like PF15941.5 ETO15586.1 - 2.1 8.8 6.1 0.4 11.2 1.5 2.1 2 1 1 3 3 3 0 FidL-like putative membrane protein CLN3 PF02487.17 ETO15586.1 - 3.2 6.7 4.8 4.1 6.3 4.8 1.1 1 0 0 1 1 1 0 CLN3 protein Arm PF00514.23 ETO15587.1 - 0.015 15.3 1.5 13 6.0 0.0 3.8 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat YidC_periplas PF14849.6 ETO15588.1 - 0.01 15.7 0.3 0.015 15.2 0.3 1.3 1 0 0 1 1 1 0 YidC periplasmic domain WD40 PF00400.32 ETO15589.1 - 5.5e-126 406.8 48.3 8e-09 36.0 0.0 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15589.1 - 6.2e-24 84.1 19.7 0.001 19.3 0.0 12.3 1 1 11 14 14 14 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15589.1 - 6.5e-17 61.5 8.9 1.5 7.7 0.0 13.3 1 1 14 16 16 16 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15589.1 - 1e-15 57.9 17.6 0.00073 18.9 0.2 7.3 5 2 2 7 7 7 5 WD40-like domain Str_synth PF03088.16 ETO15589.1 - 6.6e-09 35.8 8.8 1.9 8.7 0.1 9.1 8 3 3 11 11 11 2 Strictosidine synthase Pentapeptide PF00805.22 ETO15589.1 - 2.3e-06 27.1 3.5 6.2e-06 25.7 3.5 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Cytochrom_D1 PF02239.16 ETO15589.1 - 2.1e-05 23.2 10.3 0.82 8.1 0.1 6.1 3 1 1 6 6 6 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO15589.1 - 6.1e-05 22.5 10.5 0.86 8.9 0.0 6.6 2 2 3 7 7 7 2 Neuroblastoma-amplified sequence, N terminal DUF3475 PF11961.8 ETO15589.1 - 0.0036 17.3 6.8 0.78 9.9 0.0 6.7 8 0 0 8 8 8 1 Domain of unknown function (DUF3475) DPPIV_N PF00930.21 ETO15589.1 - 0.0038 16.0 0.5 2.9 6.6 0.1 4.7 3 2 0 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF727 PF05303.12 ETO15589.1 - 0.02 14.9 16.9 21 5.2 0.0 9.3 9 2 4 13 13 13 0 Protein of unknown function (DUF727) FLgD_tudor PF13861.6 ETO15589.1 - 0.031 14.5 0.0 4.1 7.7 0.0 4.0 2 2 0 2 2 2 0 FlgD Tudor-like domain Germane PF10646.9 ETO15589.1 - 0.15 12.9 1.6 29 5.5 0.0 4.9 4 2 0 4 4 4 0 Sporulation and spore germination Pentapeptide_4 PF13599.6 ETO15589.1 - 0.2 11.9 1.1 0.88 9.8 0.9 2.1 1 1 1 2 2 2 0 Pentapeptide repeats (9 copies) KA1 PF02149.19 ETO15590.1 - 0.074 12.9 0.0 0.17 11.7 0.0 1.7 1 0 0 1 1 1 0 Kinase associated domain 1 Fungal_KA1 PF16797.5 ETO15590.1 - 0.094 12.4 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 Fungal kinase associated-1 domain Beta-lactamase PF00144.24 ETO15591.1 - 1.7e-06 27.5 0.0 4.9e-06 26.0 0.0 1.6 1 1 0 1 1 1 1 Beta-lactamase ESCRT-II PF05871.12 ETO15592.1 - 4.7e-41 140.3 0.1 6.6e-41 139.8 0.1 1.2 1 0 0 1 1 1 1 ESCRT-II complex subunit HeH PF12949.7 ETO15592.1 - 0.063 13.0 0.1 0.12 12.1 0.1 1.4 1 0 0 1 1 1 0 HeH/LEM domain TRL PF13146.6 ETO15592.1 - 0.16 12.3 0.0 0.37 11.1 0.0 1.6 2 0 0 2 2 2 0 TRL-like protein family Aldedh PF00171.22 ETO15593.1 - 8.6e-148 492.7 1.2 5.9e-79 265.7 0.1 2.9 2 1 0 2 2 2 2 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETO15593.1 - 1.5e-05 24.6 0.1 4.2e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1487) OmdA PF13376.6 ETO15593.1 - 0.03 14.3 0.6 0.065 13.3 0.6 1.5 1 0 0 1 1 1 0 Bacteriocin-protection, YdeI or OmpD-Associated MR_MLE_C PF13378.6 ETO15594.1 - 5e-40 137.4 0.0 5.9e-40 137.2 0.0 1.0 1 0 0 1 1 1 1 Enolase C-terminal domain-like AAA PF00004.29 ETO15595.1 - 1.4e-37 129.1 0.0 3.7e-37 127.7 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO15595.1 - 1.3e-07 31.3 0.0 3.7e-07 29.8 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ETO15595.1 - 5.1e-07 29.6 0.0 2e-06 27.7 0.0 2.1 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain MIT PF04212.18 ETO15595.1 - 2.1e-06 27.7 1.7 5.5e-06 26.4 1.7 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain RuvB_N PF05496.12 ETO15595.1 - 1.3e-05 25.0 0.0 3.5e-05 23.6 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO15595.1 - 0.0002 21.4 0.0 0.0011 19.0 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO15595.1 - 0.0014 18.9 1.3 0.29 11.4 0.1 3.4 2 1 0 2 2 2 1 AAA domain TIP49 PF06068.13 ETO15595.1 - 0.0034 16.7 0.4 0.0087 15.3 0.0 1.8 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_2 PF07724.14 ETO15595.1 - 0.0036 17.4 5.6 0.0079 16.3 0.0 3.8 4 1 1 5 5 5 1 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ETO15595.1 - 0.0048 17.3 0.8 0.025 15.0 0.1 2.4 2 1 0 2 2 2 1 AAA ATPase domain AAA_14 PF13173.6 ETO15595.1 - 0.03 14.3 0.0 0.099 12.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ETO15595.1 - 0.031 13.7 0.2 0.1 12.0 0.0 1.9 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 ETO15595.1 - 0.037 14.4 0.2 1.2 9.5 0.0 2.9 2 1 0 2 2 2 0 AAA domain PH PF00169.29 ETO15596.1 - 1.2e-10 41.8 7.1 1.3e-10 41.7 1.8 3.2 2 1 0 2 2 2 1 PH domain Glu_cyclase_2 PF05096.12 ETO15597.1 - 2.7e-50 171.1 0.3 2.1e-49 168.3 0.3 1.9 1 1 0 1 1 1 1 Glutamine cyclotransferase OLF PF02191.16 ETO15597.1 - 0.0017 17.9 0.0 0.0056 16.2 0.0 1.7 1 1 0 1 1 1 1 Olfactomedin-like domain SNARE_assoc PF09335.11 ETO15598.1 - 4.8e-10 40.0 2.5 4.8e-10 40.0 2.5 3.6 3 1 0 3 3 3 1 SNARE associated Golgi protein DUF1616 PF07760.11 ETO15598.1 - 0.002 17.6 0.3 0.0076 15.7 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1616) DUF5427 PF10310.9 ETO15598.1 - 0.008 15.2 0.1 0.25 10.2 0.1 2.1 2 0 0 2 2 2 1 Family of unknown function (DUF5427) Peptidase_M56 PF05569.11 ETO15598.1 - 0.027 13.7 1.6 0.055 12.7 0.1 2.2 3 0 0 3 3 3 0 BlaR1 peptidase M56 MMM1 PF10296.9 ETO15598.1 - 0.056 12.5 0.3 0.099 11.7 0.3 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 ASFV_J13L PF05568.11 ETO15598.1 - 0.12 12.2 0.1 0.27 10.9 0.1 1.5 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF1043 PF06295.12 ETO15598.1 - 0.69 9.9 3.1 0.26 11.3 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) DUF4231 PF14015.6 ETO15598.1 - 3.6 8.1 5.9 6.9 7.2 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF4231) TPR_12 PF13424.6 ETO15599.1 - 1.6e-73 243.0 3.8 4.3e-20 71.8 0.3 5.5 4 1 1 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO15599.1 - 2e-64 211.8 0.2 1.6e-10 40.5 0.0 9.2 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO15599.1 - 3.3e-49 162.8 50.2 1.1e-08 34.5 1.8 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO15599.1 - 2.4e-45 149.3 8.0 2.1e-05 24.2 0.0 8.6 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO15599.1 - 1e-44 147.0 44.6 3.2e-08 33.2 2.0 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO15599.1 - 1.7e-36 121.4 34.7 7.1e-07 28.9 1.0 9.2 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO15599.1 - 1.5e-16 59.5 14.6 0.0055 17.0 0.5 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO15599.1 - 3.2e-13 49.4 11.8 0.11 13.1 0.2 7.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO15599.1 - 4.3e-13 48.9 0.0 4.3 8.4 0.0 7.8 7 1 1 8 8 8 1 Tetratricopeptide repeat SNAP PF14938.6 ETO15599.1 - 7.2e-13 48.6 13.2 1.1e-06 28.3 3.4 3.6 1 1 2 3 3 3 3 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 ETO15599.1 - 1.2e-08 35.5 0.0 0.067 13.8 0.0 5.7 7 1 0 7 7 4 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO15599.1 - 3.9e-08 33.3 18.7 6.8e-06 26.0 0.6 4.5 1 1 1 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETO15599.1 - 4.1e-08 32.8 44.1 0.009 15.7 8.0 10.1 9 3 3 12 12 10 4 TPR repeat DUF5113 PF17140.4 ETO15599.1 - 1.2e-05 25.2 28.0 0.069 13.0 0.1 6.7 5 2 2 7 7 6 3 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO15599.1 - 3.2e-05 24.3 1.4 1.7 9.2 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO15599.1 - 0.00012 22.1 22.4 4.7 7.4 0.1 7.4 6 1 1 7 7 7 1 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 ETO15599.1 - 0.00021 20.9 7.2 0.045 13.2 0.1 4.2 3 0 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 ETO15599.1 - 0.00027 20.8 25.5 0.005 16.8 0.5 5.0 6 0 0 6 6 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO15599.1 - 0.0004 19.9 0.0 2.6 7.3 0.0 3.1 1 1 1 3 3 3 1 MalT-like TPR region DUF627 PF04781.12 ETO15599.1 - 0.00087 19.3 4.1 13 5.8 0.0 5.1 4 0 0 4 4 4 0 Protein of unknown function (DUF627) ANAPC3 PF12895.7 ETO15599.1 - 0.0022 18.2 16.4 0.13 12.5 0.3 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO15599.1 - 0.0035 16.8 4.1 6.8 6.2 0.0 6.1 7 0 0 7 7 7 0 SHNi-TPR Tat PF00539.18 ETO15599.1 - 0.022 14.9 0.0 0.19 11.9 0.0 2.6 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) TPR_9 PF13371.6 ETO15599.1 - 0.042 14.0 0.0 0.38 10.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 ETO15599.1 - 0.071 13.4 14.5 2 8.8 0.1 6.7 8 0 0 8 8 7 0 PPR repeat ATP-synt_E_2 PF08112.11 ETO15599.1 - 0.14 12.5 2.7 46 4.4 0.0 4.6 4 0 0 4 4 3 0 ATP synthase epsilon subunit SLT PF01464.20 ETO15599.1 - 0.45 10.2 15.4 2.8 7.6 1.9 4.7 3 1 2 5 5 5 0 Transglycosylase SLT domain HTH_Bact PF18768.1 ETO15599.1 - 0.63 9.7 12.3 18 5.0 0.1 5.9 6 0 0 6 6 6 0 Helix-turn-helix bacterial domain Cass2 PF14526.6 ETO15599.1 - 0.74 10.0 11.9 0.42 10.8 0.3 3.9 4 1 0 4 4 3 0 Integron-associated effector binding protein OEP PF02321.18 ETO15599.1 - 0.85 9.4 9.8 9.8 5.9 2.5 3.9 3 1 0 3 3 3 0 Outer membrane efflux protein RPN7 PF10602.9 ETO15599.1 - 5.4 6.7 14.4 6.7 6.4 0.8 4.6 2 2 2 4 4 4 0 26S proteasome subunit RPN7 CSD PF00313.22 ETO15601.1 - 0.026 14.4 0.0 0.24 11.3 0.0 2.6 2 1 0 2 2 2 0 'Cold-shock' DNA-binding domain Mucin PF01456.17 ETO15601.1 - 0.73 9.8 19.9 1.7 8.7 19.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 ETO15601.1 - 0.97 7.3 5.6 1.3 6.9 5.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO15601.1 - 1.5 8.8 18.0 0.33 10.9 14.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) WD40 PF00400.32 ETO15603.1 - 5.9e-38 128.2 7.0 7.7e-09 36.1 0.0 6.1 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15603.1 - 2.8e-20 72.4 2.3 0.0023 18.2 0.0 5.7 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15603.1 - 6.1e-09 35.1 0.1 0.049 12.3 0.0 4.1 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO15603.1 - 1e-08 34.5 0.1 0.27 10.2 0.0 4.1 3 1 1 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO15603.1 - 5.2e-07 29.7 0.2 0.041 13.8 0.1 2.9 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO15603.1 - 1.4e-06 27.9 0.3 0.6 9.4 0.1 3.5 2 1 2 4 4 4 3 WD40-like domain DUF1797 PF08796.10 ETO15603.1 - 0.00055 20.0 0.0 2.7 8.1 0.0 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF1797) PD40 PF07676.12 ETO15603.1 - 0.0017 18.3 0.3 32 4.6 0.1 4.9 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO15603.1 - 0.0042 15.7 0.0 0.031 12.8 0.0 2.3 1 1 1 2 2 2 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO15603.1 - 0.012 14.6 0.5 14 4.5 0.0 4.1 1 1 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO15603.1 - 0.036 13.4 0.7 1.1 8.5 0.0 2.9 2 2 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Phage_CI_repr PF07022.13 ETO15603.1 - 0.047 13.8 0.0 16 5.6 0.0 2.8 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain HSP70 PF00012.20 ETO15604.1 - 2.9e-23 81.9 0.0 3.7e-23 81.6 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein S-AdoMet_synt_C PF02773.16 ETO15605.1 - 4.4e-63 211.4 0.0 6.9e-63 210.7 0.0 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, C-terminal domain S-AdoMet_synt_M PF02772.16 ETO15605.1 - 9.5e-19 67.8 0.3 1.6e-18 67.1 0.3 1.3 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, central domain S-AdoMet_synt_N PF00438.20 ETO15606.1 - 9.6e-39 132.1 0.2 1.2e-38 131.8 0.2 1.1 1 0 0 1 1 1 1 S-adenosylmethionine synthetase, N-terminal domain DUF2312 PF10073.9 ETO15606.1 - 0.075 12.7 0.5 0.11 12.2 0.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) SNARE PF05739.19 ETO15607.1 - 9.9e-17 60.7 0.3 3.1e-16 59.1 0.3 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 ETO15607.1 - 2.7e-09 37.3 6.3 2.7e-09 37.3 6.3 3.5 2 1 1 3 3 2 1 Syntaxin-like protein Use1 PF09753.9 ETO15607.1 - 0.0034 17.1 18.1 0.18 11.5 14.6 2.3 2 0 0 2 2 2 2 Membrane fusion protein Use1 SLC12 PF03522.15 ETO15607.1 - 0.21 10.6 13.5 0.28 10.2 13.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Suf PF05843.14 ETO15607.1 - 0.24 11.3 11.3 0.33 10.9 11.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) LMBR1 PF04791.16 ETO15607.1 - 0.42 9.5 16.4 0.67 8.8 8.6 2.1 2 0 0 2 2 2 0 LMBR1-like membrane protein DUF4407 PF14362.6 ETO15607.1 - 0.95 8.8 17.8 0.24 10.7 13.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 ETO15607.1 - 5.6 6.9 12.3 9.3 6.2 12.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A DUF3381 PF11861.8 ETO15607.1 - 8.5 6.2 22.4 9 6.1 4.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) DUF2477 PF10631.9 ETO15607.1 - 8.6 7.0 7.7 15 6.2 7.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2477) DUF2115 PF09888.9 ETO15607.1 - 9.3 6.7 16.0 12 6.4 5.6 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) PBP1_TM PF14812.6 ETO15607.1 - 9.4 6.7 11.4 20 5.6 0.0 3.3 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AAA_5 PF07728.14 ETO15609.1 - 3.6e-19 69.1 0.0 1.6e-11 44.4 0.0 2.4 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_5 PF17865.1 ETO15609.1 - 4.2e-11 42.9 0.0 1.2e-07 31.8 0.0 2.4 2 0 0 2 2 2 2 Midasin AAA lid domain AAA_16 PF13191.6 ETO15609.1 - 0.00037 20.9 0.0 0.00089 19.7 0.0 1.7 2 0 0 2 2 1 1 AAA ATPase domain Dynein_heavy PF03028.15 ETO15609.1 - 0.00037 20.6 0.0 0.35 11.0 0.0 2.7 2 1 0 2 2 2 2 Dynein heavy chain region D6 P-loop domain AAA_6 PF12774.7 ETO15609.1 - 0.00076 18.5 0.0 0.76 8.7 0.0 2.3 2 0 0 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_14 PF13173.6 ETO15609.1 - 0.0024 17.9 0.0 0.1 12.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ETO15609.1 - 0.0025 17.8 0.1 0.041 13.8 0.0 2.3 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea AAA PF00004.29 ETO15609.1 - 0.0064 16.9 0.0 0.021 15.2 0.0 1.9 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ETO15609.1 - 0.014 15.4 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE T2SSE PF00437.20 ETO15609.1 - 0.043 12.9 0.0 0.07 12.2 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_33 PF13671.6 ETO15609.1 - 0.047 13.8 0.0 0.17 12.1 0.0 2.0 1 1 0 1 1 1 0 AAA domain TniB PF05621.11 ETO15609.1 - 0.053 12.9 0.0 0.1 12.0 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein AAA_3 PF07726.11 ETO15609.1 - 0.057 13.3 0.0 0.23 11.3 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ETO15609.1 - 0.073 13.3 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Parvo_NS1 PF01057.17 ETO15609.1 - 0.09 11.9 0.0 0.2 10.7 0.0 1.7 1 1 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_7 PF12775.7 ETO15609.1 - 0.09 12.3 0.0 0.21 11.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region bZIP_1 PF00170.21 ETO15609.1 - 4.5 7.4 6.4 0.22 11.6 0.4 1.9 2 0 0 2 2 2 0 bZIP transcription factor WD40 PF00400.32 ETO15610.1 - 0.0037 18.1 0.1 0.024 15.5 0.2 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat zf-MIZ PF02891.20 ETO15611.1 - 0.92 9.3 7.1 0.15 11.8 2.4 2.1 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger WD40 PF00400.32 ETO15612.1 - 1.8e-76 250.1 46.2 1.3e-08 35.3 0.2 11.9 11 0 0 11 11 11 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15612.1 - 7.5e-27 93.5 11.8 0.0011 19.2 0.0 9.8 7 2 3 10 10 10 7 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15612.1 - 6.8e-17 61.3 18.2 0.0086 14.8 0.5 8.8 3 2 3 8 8 8 7 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO15612.1 - 3.4e-10 39.4 1.7 0.0067 15.4 0.0 5.9 3 1 3 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO15612.1 - 2.2e-05 23.2 0.3 8.9e-05 21.2 0.1 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO15612.1 - 0.0017 18.3 0.6 16 5.6 0.0 4.7 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO15612.1 - 0.0046 17.0 2.1 0.83 9.8 0.2 4.5 3 1 3 6 6 6 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO15612.1 - 0.023 14.3 0.2 0.64 9.6 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain DUF4072 PF13284.6 ETO15612.1 - 0.22 12.0 0.0 17 5.9 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF4072) Actin PF00022.19 ETO15613.1 - 2.3e-101 339.4 0.1 5.1e-54 183.4 0.0 2.0 1 1 1 2 2 2 2 Actin MreB_Mbl PF06723.13 ETO15613.1 - 1.1e-05 24.5 0.0 0.0055 15.6 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein Kelch_6 PF13964.6 ETO15614.1 - 0.05 13.9 0.1 4.4 7.8 0.0 3.2 3 0 0 3 3 3 0 Kelch motif tRNA_edit PF04073.15 ETO15615.1 - 2.1e-08 34.3 0.0 2.7e-08 33.9 0.0 1.1 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Cupin_8 PF13621.6 ETO15616.1 - 1.1e-40 140.0 1.2 1.3e-40 139.8 1.2 1.1 1 0 0 1 1 1 1 Cupin-like domain JmjC PF02373.22 ETO15616.1 - 4.2e-05 23.9 0.8 0.00016 22.1 0.8 2.0 1 1 0 1 1 1 1 JmjC domain, hydroxylase Cupin_4 PF08007.12 ETO15616.1 - 0.0001 21.9 0.2 0.00033 20.2 0.2 1.8 1 1 0 1 1 1 1 Cupin superfamily protein ARD PF03079.14 ETO15616.1 - 0.015 15.5 0.0 0.034 14.3 0.0 1.6 1 1 0 1 1 1 0 ARD/ARD' family Cupin_8 PF13621.6 ETO15617.1 - 3.5e-15 56.4 0.1 4.7e-15 56.0 0.1 1.2 1 0 0 1 1 1 1 Cupin-like domain HTH_27 PF13463.6 ETO15617.1 - 0.045 14.3 0.0 0.09 13.3 0.0 1.5 1 0 0 1 1 1 0 Winged helix DNA-binding domain DnaJ PF00226.31 ETO15618.1 - 3.5e-13 49.5 1.7 4.4e-08 33.1 0.1 2.7 2 1 1 3 3 3 2 DnaJ domain DUF1217 PF06748.12 ETO15618.1 - 0.099 12.7 2.3 0.35 10.9 2.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1217) DUF3395 PF11875.8 ETO15619.1 - 4.3e-41 140.4 3.9 4.3e-41 140.4 3.9 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF3395) CCSMST1 PF15013.6 ETO15619.1 - 0.032 14.4 0.0 0.15 12.3 0.0 2.2 2 0 0 2 2 2 0 CCSMST1 family EMP70 PF02990.16 ETO15621.1 - 3.3e-120 402.2 24.2 4.9e-120 401.7 24.2 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 WD40 PF00400.32 ETO15622.1 - 5.1e-24 84.1 10.6 3.8e-06 27.5 0.2 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO15622.1 - 0.0065 15.2 1.1 1.1 7.8 0.0 3.1 1 1 3 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15622.1 - 0.03 14.6 0.1 1.4 9.3 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Macoilin PF09726.9 ETO15623.1 - 8.2 4.8 14.9 9.4 4.7 14.9 1.1 1 0 0 1 1 1 0 Macoilin family Kelch_1 PF01344.25 ETO15624.1 - 5.4e-08 32.3 5.0 8.5e-06 25.3 0.5 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO15624.1 - 1.8e-07 31.2 6.8 0.00083 19.6 0.5 3.9 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO15624.1 - 0.00011 22.0 4.1 0.0077 16.2 0.4 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO15624.1 - 0.00025 21.0 1.2 0.0011 18.9 0.2 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO15624.1 - 0.00071 19.8 0.1 0.0079 16.5 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15624.1 - 0.014 15.3 1.9 20 5.3 0.3 4.1 5 0 0 5 5 5 0 Kelch motif YL1 PF05764.13 ETO15625.1 - 0.011 15.9 7.0 0.011 15.9 7.0 3.9 2 1 2 4 4 4 0 YL1 nuclear protein LRR_6 PF13516.6 ETO15625.1 - 0.024 14.7 0.4 15 6.0 0.0 3.5 3 0 0 3 3 3 0 Leucine Rich repeat PIN_4 PF13638.6 ETO15625.1 - 0.024 14.9 0.0 0.024 14.9 0.0 5.6 4 1 1 5 5 5 0 PIN domain Kinesin PF00225.23 ETO15626.1 - 6.3e-21 74.7 0.1 8e-21 74.3 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO15626.1 - 8.6e-07 29.0 0.0 3.9e-06 26.9 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding Pribosyl_synth PF14572.6 ETO15627.1 - 9.7e-26 90.9 1.1 1.8e-25 90.1 0.3 1.8 2 1 1 3 3 3 1 Phosphoribosyl synthetase-associated domain Pribosyltran_N PF13793.6 ETO15627.1 - 5.4e-20 71.5 1.6 1e-19 70.6 0.5 2.0 2 0 0 2 2 2 1 N-terminal domain of ribose phosphate pyrophosphokinase Pribosyltran PF00156.27 ETO15627.1 - 8.1e-13 48.2 0.1 1.5e-12 47.3 0.1 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ETO15627.1 - 0.028 13.9 0.0 0.039 13.4 0.0 1.3 1 0 0 1 1 1 0 Uracil phosphoribosyltransferase Atg14 PF10186.9 ETO15628.1 - 0.042 12.9 15.9 0.5 9.4 15.9 1.9 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Osmo_CC PF08946.10 ETO15628.1 - 0.054 13.8 2.6 0.054 13.8 2.6 2.1 2 1 0 2 2 2 0 Osmosensory transporter coiled coil Csm1_N PF18504.1 ETO15628.1 - 0.13 12.6 0.3 0.13 12.6 0.3 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain USP8_interact PF08941.10 ETO15628.1 - 0.52 10.1 4.0 0.18 11.6 0.4 1.9 2 0 0 2 2 2 0 USP8 interacting FapA PF03961.13 ETO15628.1 - 4.3 5.8 9.7 5.1 5.6 9.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A CDH-cyt PF16010.5 ETO15629.1 - 0.097 12.3 0.5 0.22 11.2 0.5 1.5 1 0 0 1 1 1 0 Cytochrome domain of cellobiose dehydrogenase Kelch_4 PF13418.6 ETO15630.1 - 7.4e-10 38.7 0.2 2.9e-07 30.4 0.0 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO15630.1 - 1.5e-05 25.1 1.3 0.2 12.0 0.1 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO15630.1 - 0.00034 20.1 1.0 0.02 14.5 0.1 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO15630.1 - 0.00037 20.4 1.9 0.052 13.6 3.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO15633.1 - 6.8e-05 23.0 5.6 1.5 9.2 0.2 4.3 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO15633.1 - 0.00014 21.7 3.5 0.0022 17.9 0.2 3.7 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO15633.1 - 0.00097 18.7 1.9 0.016 14.8 0.2 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO15633.1 - 0.035 14.1 2.2 8.7 6.5 0.5 4.3 5 0 0 5 5 5 0 Kelch motif DUF4252 PF14060.6 ETO15633.1 - 0.097 12.6 1.6 0.29 11.0 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4252) 2H-phosphodiest PF08975.10 ETO15633.1 - 0.15 12.0 0.0 0.3 11.1 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1868) WD40 PF00400.32 ETO15634.1 - 3.5e-118 382.1 42.7 1.3e-08 35.3 0.0 16.2 15 1 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15634.1 - 4.7e-32 110.1 15.0 0.016 15.5 0.1 12.5 1 1 13 14 14 14 11 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15634.1 - 5.6e-20 71.9 13.0 0.00041 19.8 0.0 7.2 4 3 2 7 7 7 6 WD40-like domain Ge1_WD40 PF16529.5 ETO15634.1 - 5.5e-17 61.7 9.9 0.0044 16.0 0.0 9.3 2 2 6 9 9 9 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO15634.1 - 1.5e-13 50.2 22.1 0.15 10.7 0.0 11.9 1 1 8 12 12 12 6 Nucleoporin Nup120/160 HARP PF07443.13 ETO15634.1 - 2.3e-08 33.6 0.4 2.3 7.9 0.0 8.2 8 0 0 8 8 8 1 HepA-related protein (HARP) Pentapeptide PF00805.22 ETO15634.1 - 1.7e-05 24.4 2.1 3.1e-05 23.5 2.1 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) SGL PF08450.12 ETO15634.1 - 2.9e-05 23.8 1.5 2 7.9 0.0 5.6 2 2 4 7 7 7 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 ETO15634.1 - 0.00017 21.4 15.3 6.5 6.8 0.0 8.0 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO15634.1 - 0.00024 21.1 0.4 16 5.7 0.0 5.9 6 2 0 6 6 5 0 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO15634.1 - 0.00027 21.1 2.8 0.00095 19.3 2.8 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO15634.1 - 0.00075 18.9 6.5 2.2 7.6 0.0 6.4 4 2 2 7 7 7 1 Neuroblastoma-amplified sequence, N terminal TolB_N PF04052.13 ETO15634.1 - 0.00093 19.3 0.1 27 5.0 0.0 6.1 8 0 0 8 8 7 0 TolB amino-terminal domain DUF4988 PF16378.5 ETO15634.1 - 0.04 13.6 0.5 29 4.3 0.0 4.3 5 1 0 5 5 5 0 Domain of unknown function Pentapeptide_3 PF13576.6 ETO15634.1 - 0.079 13.1 0.4 0.079 13.1 0.4 2.7 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO15634.1 - 0.17 12.0 0.1 39 4.4 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF3475) Halogen_Hydrol PF10112.9 ETO15635.1 - 0.073 13.1 4.7 0.1 12.6 4.7 1.1 1 0 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein DUF2207 PF09972.9 ETO15635.1 - 0.077 11.7 7.3 0.085 11.6 7.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF3810 PF12725.7 ETO15635.1 - 0.091 12.1 2.4 0.089 12.1 2.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Wzy_C PF04932.15 ETO15635.1 - 2.8 7.6 9.3 4.2 7.0 9.2 1.4 1 1 0 1 1 1 0 O-Antigen ligase DUF3043 PF11241.8 ETO15635.1 - 8 6.5 7.8 10 6.1 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Fumble PF03630.14 ETO15636.1 - 2.4e-47 161.7 0.0 3.1e-47 161.4 0.0 1.0 1 0 0 1 1 1 1 Fumble DUF755 PF05501.11 ETO15638.1 - 2.8 8.2 12.7 0.45 10.8 8.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF755) SR-25 PF10500.9 ETO15638.1 - 6.4 6.3 12.9 0.96 9.0 8.7 1.7 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein RRM_1 PF00076.22 ETO15639.1 - 1.6e-35 120.7 0.1 1.8e-14 53.3 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phycobilisome PF00502.19 ETO15639.1 - 0.053 13.5 0.1 0.15 12.0 0.0 1.7 2 0 0 2 2 2 0 Phycobilisome protein RRM_7 PF16367.5 ETO15639.1 - 0.12 12.5 0.1 25 5.1 0.0 3.8 3 3 0 3 3 3 0 RNA recognition motif CDC45 PF02724.14 ETO15640.1 - 0.001 17.5 6.3 0.0011 17.4 6.3 1.1 1 0 0 1 1 1 1 CDC45-like protein SAPS PF04499.15 ETO15640.1 - 0.083 11.7 3.7 0.1 11.4 3.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein ALMT PF11744.8 ETO15640.1 - 0.2 10.5 8.2 0.24 10.2 8.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.17 ETO15640.1 - 0.44 10.7 3.8 0.54 10.4 3.8 1.2 1 0 0 1 1 1 0 DDHD domain Hid1 PF12722.7 ETO15640.1 - 0.92 7.6 5.4 0.98 7.5 5.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein eIF-3c_N PF05470.12 ETO15640.1 - 0.93 7.7 13.7 1.2 7.4 13.7 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Neur_chan_memb PF02932.16 ETO15640.1 - 5.7 6.9 6.9 9.1 6.3 6.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Use1 PF09753.9 ETO15640.1 - 7.7 6.2 17.9 12 5.6 17.9 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 Acylphosphatase PF00708.18 ETO15641.1 - 4.5e-12 46.2 2.8 5.8e-12 45.9 1.0 2.0 1 1 1 2 2 2 1 Acylphosphatase Glyco_hydro_7 PF00840.20 ETO15641.1 - 0.03 13.1 1.4 0.036 12.8 1.4 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 7 Ipi1_N PF12333.8 ETO15641.1 - 0.066 13.8 0.0 0.11 13.1 0.0 1.4 1 0 0 1 1 1 0 Rix1 complex component involved in 60S ribosome maturation DUF5350 PF17299.2 ETO15641.1 - 4.6 7.8 7.9 13 6.4 1.4 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5350) WD40 PF00400.32 ETO15642.1 - 4.6e-66 217.1 23.1 2e-10 41.1 0.1 7.2 7 0 0 7 7 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15642.1 - 4.7e-25 87.7 0.5 0.00086 19.6 0.0 6.6 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15642.1 - 4.8e-12 45.8 14.6 0.00026 20.4 0.0 5.7 4 2 1 6 6 6 3 WD40-like domain Pentapeptide PF00805.22 ETO15642.1 - 4.5e-06 26.2 0.6 2.4e-05 23.9 0.5 2.2 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) PQQ_2 PF13360.6 ETO15642.1 - 9.5e-06 25.4 1.4 0.00034 20.3 1.3 3.0 1 1 1 2 2 2 1 PQQ-like domain NACHT PF05729.12 ETO15642.1 - 1.8e-05 24.7 0.0 3.9e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide_4 PF13599.6 ETO15642.1 - 0.0012 19.0 0.1 0.0054 16.9 0.1 2.2 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO15642.1 - 0.0019 18.3 0.1 0.0042 17.2 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) RelA_SpoT PF04607.17 ETO15642.1 - 0.01 16.1 0.3 0.01 16.1 0.3 2.7 2 0 0 2 2 1 0 Region found in RelA / SpoT proteins Gmad1 PF10647.9 ETO15642.1 - 0.039 13.7 0.9 0.38 10.5 0.1 2.7 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 ETO15642.1 - 0.24 11.4 4.6 62 3.7 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO15643.1 - 6.9e-15 55.2 13.1 1.8e-07 31.7 2.1 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO15643.1 - 5.5e-06 25.3 1.2 0.0046 15.7 0.2 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15643.1 - 0.00092 18.6 1.0 0.0012 18.2 1.0 1.3 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO15643.1 - 0.0011 19.3 0.2 0.034 14.4 0.1 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain SH3_13 PF18335.1 ETO15643.1 - 0.0054 16.5 2.9 0.89 9.4 0.3 2.4 1 1 1 2 2 2 2 ATP-dependent RecD-like DNA helicase SH3 domain Tim44 PF04280.15 ETO15645.1 - 3.6e-09 36.9 0.0 5e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Tim44-like domain Actin PF00022.19 ETO15646.1 - 7.9e-11 41.2 0.0 2.1e-07 29.9 0.0 2.1 1 1 1 2 2 2 2 Actin TBCA PF02970.16 ETO15647.1 - 0.00073 19.8 6.5 0.00073 19.8 6.5 2.0 2 0 0 2 2 2 1 Tubulin binding cofactor A Peptidase_M60 PF13402.6 ETO15647.1 - 0.41 10.1 4.9 0.62 9.5 0.1 2.7 1 1 1 3 3 3 0 Peptidase M60, enhancin and enhancin-like Mis14 PF08641.12 ETO15647.1 - 0.47 10.8 7.2 0.12 12.7 3.7 1.8 2 0 0 2 2 2 0 Kinetochore protein Mis14 like UPF0449 PF15136.6 ETO15647.1 - 0.88 10.1 5.6 1.6 9.2 1.8 2.7 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 WD40 PF00400.32 ETO15649.1 - 4.8e-55 182.3 27.0 7.2e-10 39.3 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15649.1 - 1.8e-18 66.6 6.1 0.00014 22.1 0.1 5.9 2 2 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15649.1 - 2.4e-08 33.4 1.3 0.07 12.1 0.0 4.6 2 1 1 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15649.1 - 2.3e-07 30.4 4.8 5.6e-07 29.2 1.5 2.2 2 0 0 2 2 2 1 WD40-like domain Nup160 PF11715.8 ETO15649.1 - 0.00011 21.0 9.8 4 6.0 0.2 6.0 2 1 5 7 7 7 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO15649.1 - 0.0015 18.4 0.1 9.8 6.3 0.1 3.6 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO15649.1 - 0.012 15.7 0.3 0.14 12.2 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5474) MCM6_C PF18263.1 ETO15650.1 - 0.069 13.4 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 MCM6 C-terminal winged-helix domain WD40 PF00400.32 ETO15651.1 - 7e-37 124.8 22.0 2.2e-06 28.3 0.2 6.9 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15651.1 - 8.1e-12 45.3 0.4 0.036 14.4 0.0 4.7 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15651.1 - 4.4e-10 38.8 5.2 0.042 12.5 0.0 4.7 2 1 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15651.1 - 6.5e-05 22.4 5.2 0.051 12.9 0.1 4.2 3 1 2 5 5 5 2 WD40-like domain BBS2_Mid PF14783.6 ETO15651.1 - 0.029 14.4 1.3 38 4.4 0.2 4.3 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region SH3_13 PF18335.1 ETO15651.1 - 7.1 6.6 8.0 48 3.9 0.0 4.5 5 0 0 5 5 5 0 ATP-dependent RecD-like DNA helicase SH3 domain PUF PF00806.19 ETO15652.1 - 1.8e-65 213.1 6.9 1.1e-08 34.2 0.0 8.3 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat sCache_2 PF17200.4 ETO15652.1 - 0.014 15.3 0.2 6 6.7 0.0 3.8 4 0 0 4 4 4 0 Single Cache domain 2 Ribosomal_S7 PF00177.21 ETO15652.1 - 0.016 14.8 0.5 3 7.5 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein S7p/S5e SapB_2 PF03489.17 ETO15652.1 - 0.017 15.2 2.5 5.3 7.2 0.0 3.7 3 0 0 3 3 3 0 Saposin-like type B, region 2 RasGEF PF00617.19 ETO15652.1 - 0.02 15.1 0.1 0.82 9.9 0.0 2.5 1 1 1 2 2 2 0 RasGEF domain Importin_rep_3 PF18806.1 ETO15652.1 - 0.025 14.6 0.1 3.1 7.9 0.0 2.8 2 1 0 2 2 2 0 Importin 13 repeat TBPIP PF07106.13 ETO15652.1 - 0.033 14.1 0.1 20 5.2 0.0 4.3 3 1 1 4 4 4 0 TBPIP/Hop2 winged helix domain Presenilin PF01080.17 ETO15652.1 - 1.7 7.4 11.4 2.4 6.8 11.4 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO15652.1 - 2.1 6.8 14.1 3 6.3 14.1 1.1 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 ETO15652.1 - 6.1 6.1 15.5 11 5.3 15.5 1.4 1 0 0 1 1 1 0 FAM76 protein NicO PF03824.16 ETO15652.1 - 8.7 5.6 12.5 17 4.6 12.5 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein WD40 PF00400.32 ETO15653.1 - 5.3e-82 267.6 28.1 2.8e-08 34.3 0.0 16.4 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15653.1 - 2.2e-23 82.4 9.1 0.011 16.0 0.0 11.0 3 3 7 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15653.1 - 1.3e-13 50.7 0.1 0.071 12.1 0.0 8.4 4 4 4 8 8 8 3 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO15653.1 - 3.2e-08 33.7 0.0 7.4e-08 32.5 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO15653.1 - 7.9e-08 31.8 3.4 1.7e-07 30.7 3.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Nbas_N PF15492.6 ETO15653.1 - 7.4e-06 25.5 2.7 2.7 7.3 0.1 6.1 4 3 1 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Pentapeptide_4 PF13599.6 ETO15653.1 - 0.0001 22.4 0.3 0.00029 21.0 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO15653.1 - 0.00021 21.6 0.0 0.00089 19.6 0.0 2.2 1 1 0 1 1 1 1 AAA domain SGL PF08450.12 ETO15653.1 - 0.0019 17.9 0.0 1 8.9 0.0 4.2 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region AAA_18 PF13238.6 ETO15653.1 - 0.0023 18.5 0.0 0.015 15.8 0.0 2.6 1 0 0 1 1 1 1 AAA domain Pentapeptide_3 PF13576.6 ETO15653.1 - 0.0029 17.7 3.5 0.0031 17.6 0.5 2.4 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO15653.1 - 0.016 15.1 5.4 21 5.2 0.0 5.5 7 0 0 7 7 5 0 WD40-like Beta Propeller Repeat TsaE PF02367.17 ETO15653.1 - 0.039 14.0 0.1 0.17 11.9 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETO15653.1 - 0.041 14.4 0.8 0.21 12.1 0.0 2.7 2 0 0 2 2 1 0 ABC transporter DUF1068 PF06364.12 ETO15653.1 - 0.053 13.4 3.0 0.68 9.8 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) PRK PF00485.18 ETO15653.1 - 0.056 13.2 0.0 0.15 11.8 0.0 1.7 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family TcdB_N PF12918.7 ETO15653.1 - 0.24 11.7 4.3 4.5 7.6 0.6 3.6 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain Aminopep PF10023.9 ETO15654.1 - 0.0024 17.3 1.9 0.0055 16.1 1.9 1.6 1 0 0 1 1 1 1 Putative aminopeptidase E1_4HB PF16191.5 ETO15654.1 - 0.085 13.1 0.1 1.5 9.0 0.1 2.6 2 0 0 2 2 2 0 Ubiquitin-activating enzyme E1 four-helix bundle RR_TM4-6 PF06459.12 ETO15656.1 - 0.2 11.5 0.6 0.28 11.0 0.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spaetzle PF16077.5 ETO15657.1 - 0.11 13.0 0.3 15 6.2 0.2 2.2 2 0 0 2 2 2 0 Spaetzle DUF4175 PF13779.6 ETO15657.1 - 0.3 8.9 0.0 0.39 8.6 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) WHAMM-JMY_N PF15920.5 ETO15658.1 - 0.013 15.4 0.4 0.63 9.9 0.5 2.3 2 0 0 2 2 2 0 N-terminal of Junction-mediating and WASP homolog-associated YqzE PF14038.6 ETO15658.1 - 0.02 14.9 0.3 0.038 14.0 0.3 1.4 1 0 0 1 1 1 0 YqzE-like protein B_lectin PF01453.24 ETO15658.1 - 0.073 13.6 0.0 0.17 12.5 0.0 1.5 2 0 0 2 2 2 0 D-mannose binding lectin Prismane PF03063.20 ETO15660.1 - 0.05 12.3 0.1 0.054 12.2 0.1 1.1 1 0 0 1 1 1 0 Prismane/CO dehydrogenase family MAJIN PF15077.6 ETO15660.1 - 0.092 12.5 5.0 0.13 12.0 5.0 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF2228 PF10228.9 ETO15660.1 - 0.17 11.6 5.1 0.23 11.2 5.1 1.3 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) FUSC PF04632.12 ETO15660.1 - 0.45 9.0 2.0 0.52 8.8 2.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Anth_synt_I_N PF04715.13 ETO15660.1 - 0.81 9.9 4.2 1.6 8.9 4.2 1.7 1 1 0 1 1 1 0 Anthranilate synthase component I, N terminal region DUF2400 PF09674.10 ETO15660.1 - 1.3 9.0 5.6 0.41 10.6 2.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) VIT1 PF01988.19 ETO15660.1 - 2.6 7.9 4.6 3.1 7.6 4.6 1.2 1 0 0 1 1 1 0 VIT family Peptidase_M1 PF01433.20 ETO15661.1 - 8.8e-15 54.9 3.0 2.1e-07 30.7 0.2 2.3 2 0 0 2 2 2 2 Peptidase family M1 domain Leuk-A4-hydro_C PF09127.11 ETO15661.1 - 4.8e-13 49.2 0.7 2.1e-12 47.1 0.2 2.2 2 0 0 2 2 2 1 Leukotriene A4 hydrolase, C-terminal zf-C2H2_jaz PF12171.8 ETO15662.1 - 0.00052 20.2 8.5 0.0043 17.3 1.2 2.8 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETO15662.1 - 0.0095 16.3 6.9 0.13 12.7 0.8 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ETO15662.1 - 0.16 12.8 2.9 0.44 11.5 1.1 2.6 2 0 0 2 2 2 0 C2H2-type zinc finger Ac76 PF05814.11 ETO15662.1 - 0.41 10.7 0.0 0.41 10.7 0.0 3.3 3 0 0 3 3 3 0 Orf76 (Ac76) DUF3385 PF11865.8 ETO15662.1 - 7.4 6.5 11.7 12 5.7 1.4 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3385) Hexokinase_1 PF00349.21 ETO15664.1 - 0.068 13.1 0.2 0.068 13.1 0.2 2.3 3 0 0 3 3 3 0 Hexokinase YMF19 PF02326.15 ETO15665.1 - 0.89 10.4 8.2 0.24 12.2 4.3 2.1 2 0 0 2 2 2 0 Plant ATP synthase F0 DUF1043 PF06295.12 ETO15666.1 - 0.02 14.9 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) DUF5320 PF17253.2 ETO15666.1 - 0.084 13.9 0.0 0.12 13.5 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5320) Ysc84 PF04366.12 ETO15666.1 - 0.17 11.6 0.0 0.24 11.2 0.0 1.2 1 0 0 1 1 1 0 Las17-binding protein actin regulator Arc_trans_TRASH PF08394.10 ETO15667.1 - 0.083 13.2 4.3 0.11 12.8 2.2 2.3 1 1 1 2 2 2 0 Archaeal TRASH domain FSAP_sig_propep PF03032.15 ETO15668.1 - 0.052 13.6 3.9 2.7 8.1 1.0 2.3 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide Fig1 PF12351.8 ETO15668.1 - 0.069 13.1 0.7 0.08 12.9 0.7 1.1 1 0 0 1 1 1 0 Ca2+ regulator and membrane fusion protein Fig1 CRA PF06589.11 ETO15668.1 - 0.32 11.1 7.9 0.39 10.8 7.9 1.2 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) WD40 PF00400.32 ETO15669.1 - 6.7e-10 39.4 4.2 2.6e-07 31.2 1.0 3.3 2 0 0 2 2 2 2 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO15669.1 - 3.9e-05 24.2 6.7 3.9e-05 24.2 6.7 2.6 2 1 1 3 3 3 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO15669.1 - 0.0026 18.0 0.3 0.026 14.8 0.0 2.5 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF1192 PF06698.11 ETO15669.1 - 0.19 11.8 4.4 1.2 9.3 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) GvpL_GvpF PF06386.11 ETO15669.1 - 2.9 7.7 5.9 11 5.9 5.9 1.8 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF CC2-LZ PF16516.5 ETO15669.1 - 3.7 8.0 21.3 0.14 12.6 5.5 3.0 3 0 0 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HECT PF00632.25 ETO15671.1 - 5e-71 239.7 0.2 8.1e-70 235.7 0.1 1.9 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) zf-RanBP PF00641.18 ETO15672.1 - 2.2e-05 23.7 2.4 4e-05 22.8 2.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ETO15672.1 - 0.014 15.4 0.1 0.77 9.9 0.1 2.5 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 ETO15672.1 - 0.052 12.9 0.1 0.12 11.8 0.1 1.6 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain SPRY PF00622.28 ETO15673.1 - 4.5e-21 75.2 0.2 1.2e-20 73.8 0.2 1.8 1 0 0 1 1 1 1 SPRY domain TFIIA PF03153.13 ETO15674.1 - 0.00032 20.8 52.2 0.00036 20.6 43.5 2.2 2 0 0 2 2 2 2 Transcription factor IIA, alpha/beta subunit GAGA_bind PF06217.12 ETO15674.1 - 0.11 12.7 21.5 1.4 9.1 14.3 2.3 2 0 0 2 2 2 0 GAGA binding protein-like family Hamartin PF04388.12 ETO15674.1 - 1.7 7.3 29.3 1.1 7.9 3.1 2.1 2 0 0 2 2 2 0 Hamartin protein Endostatin PF06482.11 ETO15674.1 - 1.7 8.0 25.2 1 8.7 18.1 2.3 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin SOG2 PF10428.9 ETO15674.1 - 6 5.9 34.2 0.85 8.7 25.2 2.1 2 0 0 2 2 2 0 RAM signalling pathway protein Neur_chan_memb PF02932.16 ETO15674.1 - 7.8 6.5 26.5 4.6 7.2 15.5 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SAPS PF04499.15 ETO15674.1 - 8.4 5.1 26.3 1.2 7.9 3.4 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein GREB1 PF15782.5 ETO15674.1 - 9.1 3.3 35.6 0.57 7.2 24.5 2.0 2 0 0 2 2 2 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 ETO15674.1 - 9.2 6.0 31.2 10 5.8 3.6 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TCP PF03634.13 ETO15674.1 - 9.7 6.7 28.2 5 7.7 16.8 2.6 2 0 0 2 2 2 0 TCP family transcription factor Coilin_N PF15862.5 ETO15675.1 - 0.015 15.1 0.0 0.015 15.1 0.0 7.1 6 1 1 7 7 7 0 Coilin N-terminus WD40 PF00400.32 ETO15676.1 - 2.5e-62 205.3 21.1 1.6e-10 41.4 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15676.1 - 5.8e-22 77.8 4.6 0.0021 18.3 0.0 6.5 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15676.1 - 3.5e-11 42.6 0.5 0.5 9.3 0.0 6.2 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15676.1 - 1.6e-10 40.8 5.3 8.4e-05 22.0 0.5 4.0 2 2 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO15676.1 - 3.5e-06 25.8 1.6 0.0043 15.6 0.1 3.4 2 1 3 5 5 5 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO15676.1 - 2.2e-05 23.3 5.9 1.4 7.5 0.0 4.9 2 2 4 6 6 6 3 Nucleoporin Nup120/160 Big_7 PF17957.1 ETO15676.1 - 0.023 15.5 3.5 18 6.2 0.1 4.0 3 2 0 3 3 3 0 Bacterial Ig domain DUF4859 PF16151.5 ETO15676.1 - 0.091 12.6 0.3 0.32 10.9 0.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4859) B3_4 PF03483.17 ETO15676.1 - 0.11 12.2 0.1 0.51 10.0 0.0 2.2 2 1 0 2 2 2 0 B3/4 domain PD40 PF07676.12 ETO15676.1 - 0.11 12.4 15.9 6.1 6.9 0.2 6.3 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO15677.1 - 2.4e-23 81.9 18.1 3.3e-06 27.7 0.0 4.6 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15677.1 - 9.5e-08 32.2 0.9 0.094 13.0 0.0 3.5 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15677.1 - 3.6e-07 29.2 4.7 0.033 12.9 0.5 3.6 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15677.1 - 1.8e-05 24.3 1.6 0.012 15.0 0.1 2.9 1 1 2 3 3 3 3 WD40-like domain Kelch_1 PF01344.25 ETO15678.1 - 7.2e-05 22.3 1.5 0.001 18.6 0.2 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO15678.1 - 0.024 14.6 3.7 0.65 10.1 0.9 3.6 3 2 0 3 3 3 0 Kelch motif LPD25 PF18840.1 ETO15678.1 - 0.034 14.7 1.0 0.068 13.7 1.0 1.4 1 0 0 1 1 1 0 Large polyvalent protein associated domain 25 Kelch_4 PF13418.6 ETO15678.1 - 0.048 13.7 1.5 1.4 9.0 0.1 2.9 2 1 1 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO15678.1 - 0.054 13.8 1.6 7.7 7.0 0.4 3.3 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO15679.1 - 1.1e-56 187.4 16.3 7.4e-09 36.1 0.2 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15679.1 - 7e-20 71.1 2.8 0.067 13.5 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15679.1 - 3.1e-13 49.7 8.9 0.00011 21.6 0.0 5.1 2 1 3 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 ETO15679.1 - 2.8e-09 36.4 7.3 0.015 14.3 0.0 5.9 3 1 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO15679.1 - 2.3e-07 29.9 4.0 0.48 9.0 0.0 5.3 1 1 3 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO15679.1 - 3.1e-05 22.7 0.1 0.024 13.2 0.0 3.5 1 1 4 5 5 5 3 Cytochrome D1 heme domain Kelch_1 PF01344.25 ETO15679.1 - 0.00055 19.5 0.2 1.2 8.8 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO15679.1 - 0.0024 17.8 0.2 0.36 10.9 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO15679.1 - 0.03 14.6 4.1 5.2 7.5 0.1 4.2 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO15679.1 - 0.089 12.8 0.2 1.6 8.8 0.1 3.2 2 0 0 2 2 2 0 Kelch motif Exo_endo_phos_2 PF14529.6 ETO15681.1 - 5.5e-07 29.5 0.4 1.9e-06 27.7 0.4 1.9 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO15681.1 - 0.04 13.4 0.0 0.07 12.6 0.0 1.4 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Sec62 PF03839.16 ETO15681.1 - 2.6 7.5 6.8 0.42 10.1 2.3 1.8 2 0 0 2 2 2 0 Translocation protein Sec62 RT_RNaseH_2 PF17919.1 ETO15682.1 - 0.0039 17.2 0.3 0.0064 16.5 0.3 1.4 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Tex_N PF09371.10 ETO15682.1 - 0.015 15.0 1.8 0.015 15.0 1.8 1.1 1 0 0 1 1 1 0 Tex-like protein N-terminal domain Glyc_hyd_38C_2 PF18230.1 ETO15683.1 - 0.0086 16.2 1.8 2.3 8.4 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolases family 38 C-terminal sub-domain Merozoite_SPAM PF07133.11 ETO15683.1 - 0.062 13.3 0.9 0.062 13.3 0.9 1.9 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) WBP-1 PF11669.8 ETO15684.1 - 0.016 15.9 2.0 0.016 15.9 0.2 1.9 2 1 0 2 2 2 0 WW domain-binding protein 1 DUF987 PF06174.11 ETO15684.1 - 0.032 14.2 0.5 1 9.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF987) ISG65-75 PF11727.8 ETO15684.1 - 0.048 12.9 2.7 0.075 12.3 2.7 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein HBB PF06777.11 ETO15685.1 - 0.013 15.2 0.6 0.3 10.7 0.0 2.6 2 0 0 2 2 2 0 Helical and beta-bridge domain PI3K_1B_p101 PF10486.9 ETO15685.1 - 0.037 11.8 8.0 0.0035 15.2 3.4 1.5 1 1 1 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GOLD_2 PF13897.6 ETO15685.1 - 0.32 11.5 4.6 0.31 11.5 0.3 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking PIP5K PF01504.18 ETO15687.1 - 7.5e-72 241.8 0.8 9e-72 241.6 0.8 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Rhodanese PF00581.20 ETO15688.1 - 1.2e-10 41.9 0.6 9.6e-10 39.0 0.6 2.1 1 1 0 1 1 1 1 Rhodanese-like domain PNK3P PF08645.11 ETO15688.1 - 0.21 11.2 2.4 0.27 10.9 1.9 1.3 1 1 0 1 1 1 0 Polynucleotide kinase 3 phosphatase Menin PF05053.13 ETO15689.1 - 2.1 6.6 9.6 2.4 6.4 9.6 1.0 1 0 0 1 1 1 0 Menin bZIP_1 PF00170.21 ETO15691.1 - 0.012 15.7 4.9 0.012 15.7 4.9 15.1 14 3 3 17 17 17 0 bZIP transcription factor Macro_2 PF14519.6 ETO15691.1 - 6.5 6.0 9.1 0.78 9.0 3.6 2.3 2 0 0 2 2 2 0 Macro-like domain MtrA PF04208.14 ETO15691.1 - 6.8 6.3 7.5 0.73 9.5 1.1 2.7 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit A DIMCO_N PF16844.5 ETO15691.1 - 8.8 6.7 8.7 4.3 7.7 0.2 4.2 3 0 0 3 3 3 0 Dinitrogenase iron-molybdenum cofactor, N-terminal Motile_Sperm PF00635.26 ETO15692.1 - 0.00031 20.5 1.7 0.001 18.9 0.1 2.7 2 0 0 2 2 2 1 MSP (Major sperm protein) domain Spc7 PF08317.11 ETO15692.1 - 0.00072 18.5 29.3 0.00072 18.5 29.3 2.4 1 1 1 2 2 2 1 Spc7 kinetochore protein CEP63 PF17045.5 ETO15692.1 - 0.0045 16.9 12.8 0.0045 16.9 12.8 3.0 1 1 1 2 2 2 1 Centrosomal protein of 63 kDa TMEM131_like PF12371.8 ETO15692.1 - 0.17 12.2 1.7 0.96 9.7 0.0 3.0 3 0 0 3 3 3 0 Transmembrane protein 131-like Phe_hydrox_dim PF07976.12 ETO15692.1 - 0.18 11.8 4.1 0.079 13.0 1.0 1.9 2 1 0 2 2 2 0 Phenol hydroxylase, C-terminal dimerisation domain TMF_TATA_bd PF12325.8 ETO15692.1 - 0.28 11.4 43.4 0.45 10.8 12.5 3.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Fez1 PF06818.15 ETO15692.1 - 0.31 11.5 41.4 1.1 9.7 26.7 3.3 1 1 1 2 2 2 0 Fez1 YjbH PF06082.11 ETO15692.1 - 0.76 8.5 15.9 1 8.1 15.9 1.3 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH ADIP PF11559.8 ETO15692.1 - 8.3 6.5 49.5 0.22 11.6 16.8 3.5 1 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding FGGY_C PF02782.16 ETO15693.1 - 1.3e-22 80.5 0.0 1.7e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain Secretin_N_2 PF07655.13 ETO15699.1 - 0.0003 21.3 1.1 0.0003 21.3 1.1 1.9 2 0 0 2 2 2 1 Secretin N-terminal domain DUF2457 PF10446.9 ETO15699.1 - 0.0034 16.6 2.3 0.0046 16.2 2.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) TFB6 PF17110.5 ETO15699.1 - 0.071 12.9 0.4 0.1 12.4 0.4 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PBP1_TM PF14812.6 ETO15699.1 - 1.1 9.7 6.2 2.8 8.4 6.2 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO15699.1 - 9.2 5.5 9.3 0.28 10.4 3.3 1.5 2 0 0 2 2 2 0 NOA36 protein Kinesin PF00225.23 ETO15700.1 - 3e-05 23.1 11.0 0.00032 19.7 1.0 2.2 1 1 1 2 2 2 2 Kinesin motor domain Popeye PF04831.13 ETO15701.1 - 1.1e-06 28.9 3.2 1.9e-06 28.1 3.2 1.6 1 1 0 1 1 1 1 Popeye protein conserved region cNMP_binding PF00027.29 ETO15701.1 - 0.00091 19.3 0.1 0.016 15.3 0.0 2.3 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Neur_chan_memb PF02932.16 ETO15701.1 - 0.014 15.5 2.1 0.019 15.0 2.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM70 PF14967.6 ETO15701.1 - 0.025 14.1 2.7 0.035 13.6 2.7 1.3 1 0 0 1 1 1 0 FAM70 protein Pox_E10 PF04805.12 ETO15701.1 - 0.16 11.9 4.2 7.4 6.5 0.0 2.4 2 0 0 2 2 2 0 E10-like protein conserved region Ndc1_Nup PF09531.10 ETO15701.1 - 1.3 7.6 11.8 0.051 12.3 5.6 1.7 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup YbgS PF13985.6 ETO15701.1 - 5.8 7.2 6.6 48 4.2 3.3 2.6 2 1 1 3 3 3 0 YbgS-like protein Arm PF00514.23 ETO15704.1 - 1.1e-61 203.1 13.4 4.2e-09 36.1 0.0 8.4 8 0 0 8 8 8 8 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO15704.1 - 1.6e-23 82.8 0.9 1.9e-05 25.0 0.0 6.6 4 2 3 7 7 7 6 HEAT-like repeat HEAT_2 PF13646.6 ETO15704.1 - 1.9e-13 50.6 0.1 0.03 14.7 0.0 5.4 3 2 1 4 4 4 3 HEAT repeats HEAT PF02985.22 ETO15704.1 - 7.1e-09 35.2 2.7 3.1 8.3 0.0 7.4 7 0 0 7 7 7 1 HEAT repeat IBB PF01749.20 ETO15704.1 - 4.1e-08 33.6 1.9 4.1e-08 33.6 1.9 2.4 2 0 0 2 2 2 1 Importin beta binding domain Arm_3 PF16186.5 ETO15704.1 - 6.1e-08 32.1 0.4 7.8e-07 28.6 0.6 2.8 3 0 0 3 3 3 1 Atypical Arm repeat V-ATPase_H_N PF03224.14 ETO15704.1 - 4.2e-06 26.3 0.1 0.00038 19.8 0.3 2.9 2 1 0 2 2 2 1 V-ATPase subunit H RICTOR_V PF14668.6 ETO15704.1 - 0.00059 20.0 1.7 0.56 10.5 0.1 4.9 5 1 1 6 6 6 2 Rapamycin-insensitive companion of mTOR, domain 5 V-ATPase_H_C PF11698.8 ETO15704.1 - 0.017 15.3 0.1 45 4.2 0.0 4.4 4 1 0 4 4 4 0 V-ATPase subunit H HEAT_PBS PF03130.16 ETO15704.1 - 0.017 15.8 4.6 85 4.3 0.0 5.8 7 1 0 7 7 7 0 PBS lyase HEAT-like repeat FolB PF02152.18 ETO15705.1 - 9.5e-25 87.3 0.0 1.3e-24 86.9 0.0 1.2 1 0 0 1 1 1 1 Dihydroneopterin aldolase PfkB PF00294.24 ETO15706.1 - 1.8e-53 181.8 0.5 1.9e-38 132.5 0.3 2.0 2 0 0 2 2 2 2 pfkB family carbohydrate kinase Glycos_transf_2 PF00535.26 ETO15707.1 - 3.8e-21 75.6 0.0 3.4e-19 69.3 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ETO15707.1 - 6.4e-09 36.0 0.0 1.9e-08 34.5 0.0 1.6 1 1 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_tranf_2_2 PF10111.9 ETO15707.1 - 0.00042 19.9 0.0 0.00062 19.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyltransferase like family 2 Glyco_transf_21 PF13506.6 ETO15707.1 - 0.12 11.9 0.0 1.7 8.1 0.0 2.3 2 0 0 2 2 2 0 Glycosyl transferase family 21 Glyco_tranf_2_4 PF13704.6 ETO15707.1 - 0.19 12.2 0.0 0.56 10.8 0.0 1.8 2 1 0 2 2 2 0 Glycosyl transferase family 2 Mo25 PF08569.11 ETO15708.1 - 2.2e-103 346.1 17.8 3e-103 345.7 17.8 1.1 1 0 0 1 1 1 1 Mo25-like CortBP2 PF09727.9 ETO15708.1 - 0.022 14.7 1.0 0.022 14.7 1.0 2.2 2 0 0 2 2 2 0 Cortactin-binding protein-2 Hydrolase_4 PF12146.8 ETO15709.1 - 4.5e-06 26.1 0.0 0.023 14.0 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO15709.1 - 0.00024 21.8 0.0 0.00037 21.2 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 ETO15709.1 - 0.00027 20.9 0.0 0.00048 20.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETO15709.1 - 0.00033 20.2 0.0 0.067 12.7 0.0 2.5 2 0 0 2 2 2 2 Prolyl oligopeptidase family BAAT_C PF08840.11 ETO15709.1 - 0.0041 17.1 0.2 0.092 12.6 0.0 2.5 2 0 0 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_1 PF00561.20 ETO15709.1 - 0.0067 16.1 0.3 1.9 8.0 0.2 2.3 2 0 0 2 2 2 2 alpha/beta hydrolase fold Tannase PF07519.11 ETO15709.1 - 0.017 14.0 0.2 0.033 13.1 0.2 1.5 1 0 0 1 1 1 0 Tannase and feruloyl esterase MIF PF01187.18 ETO15709.1 - 0.083 13.2 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Macrophage migration inhibitory factor (MIF) DUF2236 PF09995.9 ETO15711.1 - 2.7e-15 57.2 0.0 3.6e-15 56.8 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2236) Lipoprotein_10 PF03202.13 ETO15713.1 - 0.021 15.2 4.0 0.021 15.2 4.0 2.6 2 1 0 2 2 2 0 Putative mycoplasma lipoprotein, C-terminal region LRR_6 PF13516.6 ETO15714.1 - 3.6e-06 26.6 24.1 0.19 11.8 0.0 6.9 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 ETO15714.1 - 0.014 15.8 6.7 1.3e+02 3.7 0.0 6.0 5 0 0 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 ETO15714.1 - 0.27 11.7 16.9 0.19 12.2 2.5 4.6 3 2 3 6 6 6 0 Leucine Rich repeats (2 copies) Putative_PNPOx PF01243.20 ETO15715.1 - 2.4e-13 50.1 0.0 1.2e-12 47.8 0.0 2.0 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 ETO15715.1 - 3.2e-11 43.1 0.7 3.2e-11 43.1 0.7 1.7 2 0 0 2 2 2 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyridox_oxase_2 PF12766.7 ETO15715.1 - 0.0027 18.3 0.0 0.039 14.5 0.0 2.4 2 1 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase PHM7_cyt PF14703.6 ETO15715.1 - 0.018 15.3 1.7 0.051 13.8 0.1 2.1 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter Pyrid_ox_like PF16242.5 ETO15715.1 - 0.023 14.3 0.0 0.044 13.4 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like FAP206 PF12018.8 ETO15715.1 - 0.089 12.3 1.8 6 6.3 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function Exo_endo_phos PF03372.23 ETO15716.1 - 6.3e-07 29.2 0.0 1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF4275 PF14101.6 ETO15716.1 - 0.032 14.4 0.2 0.22 11.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4275) CPSF100_C PF13299.6 ETO15716.1 - 0.62 10.2 2.9 1.2 9.3 2.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Exo_endo_phos_2 PF14529.6 ETO15717.1 - 3.7e-05 23.5 2.5 0.001 18.9 0.9 2.8 2 0 0 2 2 2 2 Endonuclease-reverse transcriptase Sulfotransfer_4 PF17784.1 ETO15717.1 - 0.21 11.4 4.2 0.88 9.4 4.2 2.0 1 1 0 1 1 1 0 Sulfotransferase domain RVT_1 PF00078.27 ETO15718.1 - 6.1e-11 42.3 0.1 9.4e-08 31.8 0.0 2.0 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Cyclin_N2 PF16500.5 ETO15719.1 - 0.039 14.7 0.8 0.039 14.7 0.8 2.0 1 1 1 2 2 2 0 N-terminal region of cyclin_N Ras PF00071.22 ETO15721.1 - 5.2e-17 61.9 0.1 9e-17 61.1 0.1 1.4 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETO15721.1 - 0.1 12.0 0.1 0.32 10.4 0.0 1.8 2 0 0 2 2 2 0 ADP-ribosylation factor family GATase PF00117.28 ETO15722.1 - 0.0018 18.1 0.0 0.27 11.0 0.0 2.2 2 0 0 2 2 2 2 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO15722.1 - 0.006 16.4 0.0 0.038 13.8 0.0 2.2 2 1 0 2 2 2 1 Peptidase C26 WD40 PF00400.32 ETO15723.1 - 4.4e-62 204.5 15.0 5.8e-10 39.6 0.2 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15723.1 - 2.4e-21 75.8 7.0 0.0001 22.5 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15723.1 - 3.5e-13 49.2 2.1 0.04 12.9 0.0 6.2 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO15723.1 - 9.1e-13 48.5 2.3 7.3e-08 32.5 0.2 3.7 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO15723.1 - 2.5e-08 33.6 10.9 0.0083 15.5 0.4 4.0 1 1 2 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO15723.1 - 1.7e-05 23.6 1.0 0.0025 16.4 0.2 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO15723.1 - 0.0016 17.8 0.5 0.29 10.4 0.0 3.1 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Mid2 PF04478.12 ETO15723.1 - 0.0095 15.8 0.7 0.49 10.2 0.0 3.2 3 1 0 3 3 3 1 Mid2 like cell wall stress sensor DUF3913 PF13052.6 ETO15723.1 - 0.06 13.6 1.2 6.3 7.2 0.0 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF3913) PQQ PF01011.21 ETO15723.1 - 0.15 12.1 0.1 1.3 9.1 0.0 2.5 2 0 0 2 2 2 0 PQQ enzyme repeat PD40 PF07676.12 ETO15723.1 - 0.28 11.2 5.8 6.5 6.8 0.2 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat BLUF PF04940.12 ETO15726.1 - 0.048 13.8 0.4 0.18 11.9 0.2 2.1 2 0 0 2 2 2 0 Sensors of blue-light using FAD DUF4079 PF13301.6 ETO15727.1 - 0.16 12.1 0.0 0.18 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) WD40 PF00400.32 ETO15728.1 - 1.8e-12 47.5 3.3 8.6e-08 32.7 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15728.1 - 2.1e-05 24.7 0.2 0.21 11.9 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO15728.1 - 0.13 11.0 3.7 0.41 9.3 1.0 2.0 1 1 1 2 2 2 0 Nup133 N terminal like DUF2368 PF10166.9 ETO15730.1 - 0.1 12.2 0.5 0.24 11.0 0.2 1.7 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2368) ANAPC4_WD40 PF12894.7 ETO15731.1 - 0.00022 21.4 0.0 0.21 11.9 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO15731.1 - 0.0016 19.2 3.0 6.8 7.7 0.0 3.8 4 1 0 4 4 4 2 WD domain, G-beta repeat PD40 PF07676.12 ETO15731.1 - 0.0054 16.6 0.1 1.5 8.9 0.0 2.7 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO15731.1 - 0.023 13.8 0.3 0.044 12.8 0.2 1.5 1 1 1 2 2 2 0 Coatomer WD associated region eIF2A PF08662.11 ETO15731.1 - 0.032 14.1 0.3 1.7 8.5 0.1 2.4 1 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Nbas_N PF15492.6 ETO15731.1 - 0.14 11.4 0.1 0.5 9.7 0.0 1.9 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Mrpl_C PF18502.1 ETO15732.1 - 0.14 12.5 0.3 0.25 11.7 0.3 1.4 1 0 0 1 1 1 0 54S ribosomal protein L8 C-terminal domain Lactamase_B PF00753.27 ETO15733.1 - 2.5e-14 53.7 0.1 3.5e-14 53.3 0.1 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily BLACT_WH PF17778.1 ETO15733.1 - 5e-13 48.8 0.0 9.2e-13 48.0 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase associated winged helix domain Lactamase_B_2 PF12706.7 ETO15733.1 - 0.0013 18.3 0.1 0.002 17.7 0.1 1.4 1 1 0 1 1 1 1 Beta-lactamase superfamily domain UN_NPL4 PF11543.8 ETO15733.1 - 0.081 13.4 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 DNA_ligase_OB_2 PF14743.6 ETO15733.1 - 0.26 11.4 0.5 0.56 10.3 0.1 1.7 2 0 0 2 2 2 0 DNA ligase OB-like domain DUF2805 PF10985.8 ETO15734.1 - 0.041 14.3 1.0 0.077 13.4 0.0 2.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2805) PBP1_TM PF14812.6 ETO15734.1 - 0.052 13.9 1.3 0.091 13.1 1.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal BatD PF13584.6 ETO15734.1 - 0.13 11.1 0.3 0.15 10.9 0.3 1.1 1 0 0 1 1 1 0 Oxygen tolerance WD40 PF00400.32 ETO15736.1 - 2.3e-67 221.3 17.2 2.6e-11 43.9 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15736.1 - 1e-19 70.6 1.9 0.024 14.9 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15736.1 - 8.1e-12 44.7 0.0 0.24 10.3 0.0 5.5 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15736.1 - 1.5e-08 34.4 0.8 0.056 12.8 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO15736.1 - 2.9e-08 32.8 5.1 0.031 12.9 0.1 4.9 1 1 4 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO15736.1 - 3.5e-08 33.2 8.4 2.6 8.1 0.0 7.0 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO15736.1 - 1.8e-05 24.8 0.2 3.1 8.0 0.0 5.0 3 1 1 4 4 4 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO15736.1 - 0.00023 19.8 0.4 0.65 8.5 0.0 3.4 1 1 3 4 4 4 2 Cytochrome D1 heme domain SGL PF08450.12 ETO15736.1 - 0.00075 19.2 0.1 0.033 13.8 0.0 2.4 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Nucleoporin_N PF08801.11 ETO15736.1 - 0.00076 18.3 8.6 1 8.1 3.9 4.5 1 1 3 4 4 4 2 Nup133 N terminal like nos_propeller PF18764.1 ETO15736.1 - 0.0016 18.3 0.0 17 5.4 0.0 4.9 4 1 3 7 7 7 0 Nitrous oxide reductase propeller repeat Vac_Fusion PF02346.16 ETO15736.1 - 0.047 13.3 0.1 5.6 6.7 0.0 3.2 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 PQQ_2 PF13360.6 ETO15736.1 - 0.08 12.5 0.0 0.22 11.1 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain Proteasome_A_N PF10584.9 ETO15736.1 - 0.15 11.8 7.5 7.5 6.3 0.1 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature BROMI PF14961.6 ETO15737.1 - 0.0081 13.6 3.8 0.0091 13.5 3.8 1.1 1 0 0 1 1 1 1 Broad-minded protein RhoGEF PF00621.20 ETO15738.1 - 1.3e-13 51.6 0.2 1.3e-13 51.6 0.2 1.8 2 0 0 2 2 2 1 RhoGEF domain Bcl-2_BAD PF10514.9 ETO15738.1 - 0.049 14.1 0.3 0.09 13.2 0.3 1.4 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD RRN3 PF05327.11 ETO15738.1 - 0.49 8.9 9.4 0.57 8.7 9.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SLC12 PF03522.15 ETO15738.1 - 2.2 7.2 10.6 2.9 6.8 10.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 ETRAMP PF09716.10 ETO15739.1 - 0.15 12.1 0.1 0.15 12.1 0.1 2.0 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF629 PF04780.12 ETO15740.1 - 0.00071 18.2 0.5 0.0011 17.6 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF629) zf-Di19 PF05605.12 ETO15740.1 - 0.0049 17.1 0.8 0.011 16.0 0.8 1.6 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 ETO15740.1 - 0.011 16.1 5.5 0.021 15.3 2.3 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO15740.1 - 0.014 16.2 1.8 0.068 14.0 1.8 2.3 1 0 0 1 1 1 0 C2H2-type zinc finger EVI2A PF05399.11 ETO15741.1 - 0.024 14.2 1.9 0.15 11.7 1.0 2.0 1 1 1 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) DUF2151 PF10221.9 ETO15742.1 - 0.014 14.0 2.8 0.016 13.9 2.8 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Spore_III_AB PF09548.10 ETO15742.1 - 0.095 12.8 0.8 0.11 12.6 0.8 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) SLM4 PF16818.5 ETO15742.1 - 1.4 8.9 5.6 2.5 8.1 5.6 1.5 1 1 0 1 1 1 0 Protein SLM4 DUF2431 PF10354.9 ETO15743.1 - 8.1e-32 110.8 1.5 8.1e-32 110.8 1.5 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) F-box_4 PF15966.5 ETO15744.1 - 0.21 11.5 0.7 5.9 6.8 0.1 2.5 2 0 0 2 2 2 0 F-box SDA1 PF05285.12 ETO15744.1 - 1.2 8.5 10.0 1.7 8.0 10.0 1.2 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ETO15744.1 - 2.3 7.5 13.5 3.1 7.0 13.5 1.1 1 0 0 1 1 1 0 BUD22 Ras PF00071.22 ETO15745.1 - 7.3e-26 90.7 2.0 7.4e-26 90.7 0.8 1.6 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO15745.1 - 9.5e-09 35.5 0.1 1.7e-08 34.7 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO15745.1 - 4.5e-06 26.2 0.1 8e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO15745.1 - 1.3e-05 24.8 0.2 2.1e-05 24.2 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO15745.1 - 0.00072 19.0 0.2 0.0012 18.2 0.2 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region RRM_1 PF00076.22 ETO15747.1 - 7.9e-19 67.3 0.1 4.3e-07 29.7 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mit_ribos_Mrp51 PF11709.8 ETO15750.1 - 0.001 18.7 2.2 0.03 13.9 0.4 2.8 1 1 1 2 2 2 1 Mitochondrial ribosomal protein subunit ApoLp-III PF07464.11 ETO15750.1 - 0.049 13.7 0.2 0.049 13.7 0.2 2.9 2 1 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) VPS13_C PF16909.5 ETO15750.1 - 0.052 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Vacuolar-sorting-associated 13 protein C-terminal ApoC-I PF04691.12 ETO15750.1 - 1.4 8.9 12.6 0.58 10.1 0.1 4.7 2 1 3 6 6 6 0 Apolipoprotein C-I (ApoC-1) VPR PF00522.18 ETO15750.1 - 4.8 7.3 6.6 50 4.0 0.2 3.8 2 1 3 5 5 5 0 VPR/VPX protein Amidase02_C PF12123.8 ETO15750.1 - 5.8 6.7 14.3 1e+02 2.7 0.0 6.4 7 0 0 7 7 7 0 N-acetylmuramoyl-l-alanine amidase HEAT_2 PF13646.6 ETO15751.1 - 6e-06 26.6 0.1 0.034 14.5 0.0 3.3 3 0 0 3 3 3 2 HEAT repeats DUF919 PF06034.11 ETO15752.1 - 0.12 12.2 0.3 0.25 11.2 0.3 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) DUF2924 PF11149.8 ETO15753.1 - 0.025 15.0 1.0 0.51 10.7 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2924) WD40 PF00400.32 ETO15754.1 - 3.4e-20 72.0 13.9 8.9e-07 29.5 1.6 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO15754.1 - 1.2e-06 27.5 2.4 0.0016 17.2 0.2 3.4 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO15754.1 - 1.1e-05 25.7 0.4 0.093 13.0 0.0 3.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF2203 PF09969.9 ETO15754.1 - 0.024 15.4 0.6 0.13 13.0 0.0 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DIT1_PvcA PF05141.12 ETO15755.1 - 0.027 13.9 1.3 0.029 13.8 0.7 1.4 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein SSXT PF05030.12 ETO15755.1 - 0.1 12.2 0.1 0.17 11.5 0.1 1.6 1 1 0 1 1 1 0 SSXT protein (N-terminal region) RasGEF PF00617.19 ETO15756.1 - 3.5e-26 92.5 3.3 3e-19 69.9 0.5 2.6 3 0 0 3 3 3 2 RasGEF domain RecG_N PF17190.4 ETO15756.1 - 0.095 13.4 0.1 40 5.0 0.1 3.2 3 0 0 3 3 3 0 RecG N-terminal helical domain SnoaL_2 PF12680.7 ETO15757.1 - 0.077 13.7 0.0 0.1 13.2 0.0 1.2 1 0 0 1 1 1 0 SnoaL-like domain Pkinase PF00069.25 ETO15759.1 - 0.0073 15.7 0.0 0.014 14.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Sec16 PF12932.7 ETO15759.1 - 0.17 12.4 0.4 0.27 11.8 0.4 1.4 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region ADK PF00406.22 ETO15760.1 - 6.4e-52 175.7 0.1 5.6e-38 130.4 0.0 2.2 1 1 1 2 2 2 2 Adenylate kinase AAA_17 PF13207.6 ETO15760.1 - 1.3e-20 74.2 0.6 1.2e-18 67.9 0.0 2.5 2 1 1 3 3 3 1 AAA domain ADK_lid PF05191.14 ETO15760.1 - 6.6e-13 48.4 0.0 3.1e-12 46.2 0.0 2.1 1 1 0 1 1 1 1 Adenylate kinase, active site lid AAA_33 PF13671.6 ETO15760.1 - 0.0017 18.5 0.0 0.041 14.1 0.0 2.7 1 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO15760.1 - 0.0021 18.6 0.1 0.027 15.0 0.1 2.3 1 1 0 1 1 1 1 AAA domain Hydin_ADK PF17213.3 ETO15760.1 - 0.0038 17.5 1.1 3.4 7.9 0.0 2.8 2 1 1 3 3 3 2 Hydin Adenylate kinase-like domain LtuB PF17455.2 ETO15760.1 - 0.54 10.9 4.2 7.5 7.3 0.1 2.4 2 0 0 2 2 2 0 Late transcription unit B Cecropin PF00272.19 ETO15760.1 - 5.1 6.9 6.0 27 4.6 0.2 2.5 2 0 0 2 2 2 0 Cecropin family Sel1 PF08238.12 ETO15761.1 - 6.5e-16 58.4 0.1 2.4e-05 24.8 0.0 4.5 5 0 0 5 5 5 3 Sel1 repeat TPR_2 PF07719.17 ETO15761.1 - 0.0054 16.8 0.1 31 5.0 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO15761.1 - 0.11 12.9 0.6 68 4.2 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO15761.1 - 0.2 11.3 11.5 6 6.6 0.4 4.7 4 1 0 4 4 4 0 TPR repeat Sel1 PF08238.12 ETO15762.1 - 1.8e-13 50.7 4.2 1.8e-05 25.3 0.1 3.2 3 0 0 3 3 3 3 Sel1 repeat TPR_6 PF13174.6 ETO15762.1 - 0.0032 18.0 0.2 0.16 12.7 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO15762.1 - 1.9 8.4 7.4 75 3.4 0.1 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat HEAT_2 PF13646.6 ETO15763.1 - 7.5e-14 51.9 0.1 6.6e-13 48.9 0.0 2.0 1 1 0 2 2 2 1 HEAT repeats HEAT_PBS PF03130.16 ETO15763.1 - 2.9e-08 33.6 0.0 0.0011 19.5 0.0 3.4 4 0 0 4 4 4 2 PBS lyase HEAT-like repeat HEAT PF02985.22 ETO15763.1 - 0.00013 21.9 0.0 0.019 15.2 0.0 3.1 3 0 0 3 3 3 1 HEAT repeat TAF6_C PF07571.13 ETO15763.1 - 0.02 15.2 0.0 3 8.2 0.0 2.6 1 1 2 3 3 3 0 TAF6 C-terminal HEAT repeat domain Arm PF00514.23 ETO15763.1 - 0.091 12.8 0.0 0.2 11.8 0.0 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETO15764.1 - 7.8e-08 32.6 0.0 1.7e-07 31.5 0.0 1.6 1 1 0 1 1 1 1 HEAT repeats HEAT_PBS PF03130.16 ETO15764.1 - 9.4e-05 22.7 0.0 1.1 10.1 0.0 3.3 3 0 0 3 3 3 2 PBS lyase HEAT-like repeat RPN6_N PF18055.1 ETO15764.1 - 0.02 15.3 2.9 0.24 11.8 0.1 2.5 2 1 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain NUC PF18510.1 ETO15764.1 - 2.4 8.6 9.9 2.4 8.5 2.1 2.3 2 0 0 2 2 2 0 Nuclease domain DDE_Tnp_Tn3 PF01526.17 ETO15765.1 - 0.0046 15.8 0.1 0.0079 15.0 0.1 1.4 1 0 0 1 1 1 1 Tn3 transposase DDE domain CBP_BcsF PF11120.8 ETO15766.1 - 0.016 15.3 0.6 0.016 15.3 0.6 2.2 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsF PseudoU_synth_1 PF01416.20 ETO15767.1 - 3.1e-09 37.2 0.4 1.5e-08 35.1 0.4 2.1 1 1 0 1 1 1 1 tRNA pseudouridine synthase SRP9-21 PF05486.12 ETO15767.1 - 0.3 11.5 3.0 1.8 9.0 3.0 2.3 1 1 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) CDC45 PF02724.14 ETO15767.1 - 1.2 7.4 9.3 1.9 6.7 9.3 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF1877 PF08974.10 ETO15768.1 - 0.0034 17.5 0.6 0.0056 16.8 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1877) Lipocalin_5 PF13924.6 ETO15768.1 - 0.055 13.3 0.0 0.098 12.4 0.0 1.4 1 0 0 1 1 1 0 Lipocalin-like domain WD40_4 PF16300.5 ETO15769.1 - 3.4e-19 68.4 0.1 6.3e-19 67.6 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 ETO15769.1 - 6.7e-09 36.3 7.4 3.7e-05 24.4 0.0 3.4 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15769.1 - 8.1e-06 26.1 0.1 0.0025 18.1 0.1 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15769.1 - 0.00023 19.9 0.3 0.00042 19.1 0.1 1.5 2 0 0 2 2 2 1 Nucleoporin Nup120/160 bZIP_2 PF07716.15 ETO15769.1 - 2.1 8.5 5.5 0.62 10.2 2.3 1.7 2 0 0 2 2 2 0 Basic region leucine zipper tRNA_bind PF01588.20 ETO15770.1 - 4.7e-15 55.5 0.3 6.3e-14 51.9 0.3 2.2 1 1 0 1 1 1 1 Putative tRNA binding domain Anticodon_1 PF08264.13 ETO15770.1 - 0.081 12.9 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ETO15771.1 - 8e-18 64.4 0.0 9.2e-18 64.2 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ETO15771.1 - 3.1e-16 58.8 0.0 3.9e-16 58.4 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ETO15771.1 - 1.6e-07 30.9 0.0 2.2e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1f PF01921.18 ETO15771.1 - 1.9e-05 23.8 0.0 2.2e-05 23.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (K) tRNA-synt_1b PF00579.25 ETO15771.1 - 0.029 13.7 0.0 0.031 13.6 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Orthopox_A43R PF06517.11 ETO15772.1 - 0.066 13.0 0.1 0.09 12.6 0.1 1.2 1 0 0 1 1 1 0 Orthopoxvirus A43R protein Pkinase PF00069.25 ETO15773.1 - 5e-33 114.6 0.0 5.5e-33 114.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15773.1 - 1.3e-09 37.7 0.0 1.9e-09 37.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO15773.1 - 0.039 13.3 0.0 0.051 12.9 0.0 1.3 1 0 0 1 1 1 0 Kinase-like DUF3645 PF12359.8 ETO15774.1 - 0.025 13.9 0.2 0.19 11.2 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3645) Utp21 PF04192.12 ETO15775.1 - 5.3e-14 52.3 5.0 9.1e-14 51.5 5.0 1.3 1 0 0 1 1 1 1 Utp21 specific WD40 associated putative domain WD40 PF00400.32 ETO15775.1 - 1.5e-07 32.0 8.5 2.6e-06 28.0 0.5 4.3 4 0 0 4 4 4 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15775.1 - 0.0019 18.4 0.0 0.08 13.3 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain HPS3_N PF14761.6 ETO15775.1 - 0.012 15.2 0.0 0.25 10.8 0.0 2.2 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 3 Shisa PF13908.6 ETO15776.1 - 0.006 16.9 3.4 0.007 16.6 3.4 1.3 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator DUF4577 PF15145.6 ETO15776.1 - 0.009 16.0 1.8 0.012 15.6 1.8 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) GP41 PF00517.17 ETO15776.1 - 0.11 12.4 1.3 0.14 12.0 1.3 1.2 1 0 0 1 1 1 0 Retroviral envelope protein Glucan_synthase PF02364.15 ETO15776.1 - 0.11 10.6 3.1 0.13 10.4 3.1 1.0 1 0 0 1 1 1 0 1,3-beta-glucan synthase component DUF2207 PF09972.9 ETO15776.1 - 0.5 9.1 4.7 0.53 9.0 4.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4191 PF13829.6 ETO15776.1 - 0.81 9.0 4.5 1.1 8.5 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) ASFV_J13L PF05568.11 ETO15776.1 - 8.8 6.0 10.0 12 5.5 10.0 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein NAD_Gly3P_dh_N PF01210.23 ETO15777.1 - 3.2e-44 150.6 0.1 4.1e-44 150.3 0.1 1.1 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_Gly3P_dh_C PF07479.14 ETO15777.1 - 2.1e-11 44.3 0.4 4.3e-11 43.3 0.4 1.5 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus 3HCDH_N PF02737.18 ETO15777.1 - 3.6e-07 30.3 0.0 8e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ETO15777.1 - 8.2e-07 28.8 0.1 1.2e-06 28.2 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA F420_oxidored PF03807.17 ETO15777.1 - 1.5e-06 28.6 0.0 3.7e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent Sacchrp_dh_NADP PF03435.18 ETO15777.1 - 1.2e-05 25.6 0.0 5.2e-05 23.5 0.0 1.9 2 0 0 2 2 2 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_2 PF03446.15 ETO15777.1 - 3.6e-05 24.0 0.0 8.2e-05 22.8 0.0 1.5 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_10 PF13460.6 ETO15777.1 - 0.00048 20.1 0.0 0.00067 19.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding GIDA PF01134.22 ETO15777.1 - 0.00056 19.1 0.0 0.00073 18.7 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ETO15777.1 - 0.02 14.1 0.3 0.032 13.5 0.2 1.4 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase IlvN PF07991.12 ETO15777.1 - 0.031 13.9 0.1 0.13 11.8 0.1 2.0 1 1 1 2 2 2 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain PALP PF00291.25 ETO15777.1 - 0.034 13.6 0.0 0.058 12.8 0.0 1.3 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme OCD_Mu_crystall PF02423.15 ETO15777.1 - 0.041 12.8 0.0 0.057 12.3 0.0 1.2 1 0 0 1 1 1 0 Ornithine cyclodeaminase/mu-crystallin family Pyr_redox PF00070.27 ETO15777.1 - 0.045 14.3 0.1 0.55 10.8 0.0 2.4 2 1 1 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase DpaA_N PF16924.5 ETO15777.1 - 0.058 13.5 0.1 0.24 11.5 0.1 2.0 1 1 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain NAD_binding_7 PF13241.6 ETO15777.1 - 0.062 13.8 0.1 0.11 12.9 0.0 1.5 2 0 0 2 2 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 ETO15777.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.5 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase OCC1 PF15506.6 ETO15778.1 - 1.9 8.7 9.0 1.2 9.3 2.8 2.2 2 0 0 2 2 2 0 OCC1 family DENN PF02141.21 ETO15779.1 - 2.2e-37 128.8 6.4 3.7e-37 128.1 6.4 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain Vac7 PF12751.7 ETO15779.1 - 0.39 10.1 11.6 0.95 8.8 11.6 1.6 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Zn_ribbon_recom PF13408.6 ETO15780.1 - 0.047 14.2 2.2 0.06 13.9 1.5 1.7 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain DrsE PF02635.15 ETO15781.1 - 3.7e-08 33.7 0.0 6.1e-08 33.0 0.0 1.3 1 0 0 1 1 1 1 DsrE/DsrF-like family Rhodanese PF00581.20 ETO15781.1 - 0.00021 21.7 0.0 0.6 10.6 0.0 2.6 2 0 0 2 2 2 2 Rhodanese-like domain DUF4465 PF14717.6 ETO15781.1 - 0.089 13.1 0.1 0.15 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4465) Regulator_TrmB PF11495.8 ETO15781.1 - 0.092 11.9 0.0 1.2 8.3 0.0 2.0 2 0 0 2 2 2 0 Archaeal transcriptional regulator TrmB DUF3573 PF12097.8 ETO15782.1 - 0.018 13.9 0.0 0.025 13.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) LRR_4 PF12799.7 ETO15782.1 - 0.033 14.6 7.3 9.6 6.8 0.1 4.2 3 2 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO15782.1 - 0.35 11.6 8.8 29 5.8 0.1 4.6 5 1 0 5 5 5 0 Leucine Rich Repeat LRR_6 PF13516.6 ETO15782.1 - 1.3 9.2 5.7 45 4.5 0.0 4.5 5 0 0 5 5 5 0 Leucine Rich repeat MucBP PF06458.12 ETO15783.1 - 0.19 12.8 0.4 3.1 8.9 0.1 2.3 2 0 0 2 2 2 0 MucBP domain Helicase_C_2 PF13307.6 ETO15784.1 - 1.1e-53 181.9 1.6 2.2e-53 180.9 0.1 2.3 2 0 0 2 2 2 1 Helicase C-terminal domain DEAD_2 PF06733.15 ETO15784.1 - 3.5e-43 147.3 15.2 6.7e-41 139.8 12.9 3.1 2 1 0 2 2 2 1 DEAD_2 DEAD PF00270.29 ETO15784.1 - 0.00037 20.3 1.5 0.027 14.2 0.1 3.2 2 2 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO15784.1 - 0.0014 18.9 0.2 2.7 8.2 0.0 3.8 3 0 0 3 3 3 1 AAA domain 7TM_GPCR_Srt PF10321.9 ETO15784.1 - 0.0056 15.7 1.8 0.14 11.1 0.2 2.2 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srt AAA_25 PF13481.6 ETO15784.1 - 0.11 12.0 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain SNF2_N PF00176.23 ETO15784.1 - 1.2 7.7 10.8 4.7 5.8 10.0 2.3 2 1 0 2 2 2 0 SNF2 family N-terminal domain cNMP_binding PF00027.29 ETO15785.1 - 7e-09 35.6 0.0 0.0039 17.2 0.0 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain CS PF04969.16 ETO15786.1 - 4.9e-07 30.7 3.3 5.9e-07 30.4 2.0 1.8 2 0 0 2 2 2 1 CS domain PRA1 PF03208.19 ETO15786.1 - 0.017 14.8 1.1 0.38 10.4 0.1 2.1 2 0 0 2 2 2 0 PRA1 family protein MAPEG PF01124.18 ETO15786.1 - 0.14 12.1 1.6 0.35 10.8 0.0 2.0 2 0 0 2 2 2 0 MAPEG family DUF1600 PF07667.11 ETO15786.1 - 7.2 6.9 10.4 4.7 7.4 0.7 3.1 2 2 0 2 2 2 0 Protein of unknown function (DUF1600) Gtr1_RagA PF04670.12 ETO15787.1 - 2.8e-18 66.1 0.0 3.6e-18 65.8 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region DNA_ligase_A_M PF01068.21 ETO15788.1 - 6.9e-59 198.9 1.1 1.3e-58 198.0 1.1 1.5 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_N PF04675.14 ETO15788.1 - 2.7e-40 138.5 0.0 5.3e-40 137.6 0.0 1.5 1 0 0 1 1 1 1 DNA ligase N terminus DNA_ligase_A_C PF04679.15 ETO15788.1 - 1.5e-21 76.8 0.0 3.4e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region Presenilin PF01080.17 ETO15789.1 - 0.73 8.5 3.2 0.8 8.4 3.2 1.1 1 0 0 1 1 1 0 Presenilin DUF3835 PF12927.7 ETO15789.1 - 2.2 9.2 6.3 3.9 8.4 1.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3835) Menin PF05053.13 ETO15789.1 - 8.6 4.6 8.1 8.8 4.5 8.1 1.1 1 0 0 1 1 1 0 Menin Ank_4 PF13637.6 ETO15790.1 - 0.008 16.7 0.2 0.019 15.5 0.1 1.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Med6 PF04934.14 ETO15790.1 - 0.036 13.9 0.1 0.069 13.0 0.1 1.5 1 0 0 1 1 1 0 MED6 mediator sub complex component Ank_2 PF12796.7 ETO15790.1 - 0.096 13.3 0.1 0.54 10.9 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) U3_snoRNA_assoc PF08297.11 ETO15791.1 - 0.016 15.9 2.2 0.027 15.2 2.2 1.3 1 0 0 1 1 1 0 U3 snoRNA associated Afi1 PF07792.12 ETO15791.1 - 0.029 14.8 0.5 0.052 14.0 0.5 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking MFS_2 PF13347.6 ETO15791.1 - 0.035 12.7 0.5 0.083 11.4 0.0 1.7 2 0 0 2 2 2 0 MFS/sugar transport protein Pho86 PF11124.8 ETO15791.1 - 3.1 7.2 12.7 0.076 12.5 1.3 2.0 1 1 1 2 2 2 0 Inorganic phosphate transporter Pho86 Lzipper-MIP1 PF14389.6 ETO15795.1 - 0.0076 16.5 2.5 0.0076 16.5 2.5 3.2 4 0 0 4 4 4 1 Leucine-zipper of ternary complex factor MIP1 CorA PF01544.18 ETO15795.1 - 0.27 10.5 11.7 0.37 10.0 1.1 2.9 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF1664 PF07889.12 ETO15795.1 - 2.4 8.2 12.8 9.3 6.3 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) ATP-grasp_4 PF13535.6 ETO15795.1 - 6.9 6.2 11.2 4.3 6.9 0.1 3.7 4 1 1 5 5 5 0 ATP-grasp domain SusF_SusE PF16411.5 ETO15796.1 - 1.4 9.5 5.0 9.3 6.8 5.0 2.3 1 1 0 1 1 1 0 Outer membrane protein SusF_SusE LAGLIDADG_3 PF14528.6 ETO15796.1 - 4.2 7.8 7.2 1.2 9.4 0.4 3.2 3 0 0 3 3 3 0 LAGLIDADG-like domain 3H PF02829.14 ETO15796.1 - 4.7 7.6 11.8 1.5 9.1 0.7 2.8 1 1 1 2 2 2 0 3H domain Golgin_A5 PF09787.9 ETO15796.1 - 9.9 5.5 35.3 0.13 11.7 21.6 2.9 2 1 1 3 3 3 0 Golgin subfamily A member 5 ORF6N PF10543.9 ETO15796.1 - 9.9 6.4 14.7 2.1 8.6 2.8 3.6 3 1 0 3 3 3 0 ORF6N domain DUF4618 PF15397.6 ETO15797.1 - 7e-07 28.9 50.1 0.00034 20.1 18.5 3.2 1 1 2 3 3 3 3 Domain of unknown function (DUF4618) Lebercilin PF15619.6 ETO15797.1 - 1e-06 28.5 63.3 8.9e-05 22.2 15.5 3.7 1 1 1 3 3 3 3 Ciliary protein causing Leber congenital amaurosis disease Baculo_PEP_C PF04513.12 ETO15797.1 - 0.00047 20.2 28.7 0.76 9.8 5.9 3.6 1 1 1 3 3 3 3 Baculovirus polyhedron envelope protein, PEP, C terminus HOOK PF05622.12 ETO15797.1 - 0.0094 14.2 57.0 0.15 10.2 11.1 2.7 1 1 1 2 2 2 2 HOOK protein Csm1_N PF18504.1 ETO15797.1 - 0.035 14.5 3.8 0.035 14.5 3.8 7.0 1 1 6 7 7 7 0 Csm1 N-terminal domain FlaC_arch PF05377.11 ETO15797.1 - 0.035 14.5 30.4 5.2 7.5 0.6 6.3 6 0 0 6 6 6 0 Flagella accessory protein C (FlaC) Tropomyosin_1 PF12718.7 ETO15797.1 - 0.037 14.2 62.4 0.17 12.1 18.1 4.6 1 1 4 5 5 5 0 Tropomyosin like DUF724 PF05266.14 ETO15797.1 - 0.046 13.5 46.4 0.081 12.7 11.5 3.3 1 1 2 3 3 2 0 Protein of unknown function (DUF724) Filament PF00038.21 ETO15797.1 - 0.048 13.2 53.5 0.37 10.3 53.5 2.5 1 1 0 1 1 1 0 Intermediate filament protein AAA_13 PF13166.6 ETO15797.1 - 0.059 12.0 40.2 0.17 10.5 8.9 2.7 1 1 1 2 2 2 0 AAA domain GAS PF13851.6 ETO15797.1 - 0.07 12.5 61.4 0.12 11.7 4.0 3.6 1 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 ETO15797.1 - 0.094 12.8 33.6 0.81 9.7 1.8 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) PKcGMP_CC PF16808.5 ETO15797.1 - 0.12 12.3 0.5 0.12 12.3 0.5 6.7 6 2 2 8 8 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase TPR_MLP1_2 PF07926.12 ETO15797.1 - 0.12 12.5 61.6 0.066 13.3 23.1 3.7 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Atg14 PF10186.9 ETO15797.1 - 0.18 10.9 49.5 0.067 12.3 20.1 2.8 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GP20 PF06810.11 ETO15797.1 - 0.35 10.7 46.2 0.034 13.9 4.4 4.8 1 1 2 4 4 4 0 Phage minor structural protein GP20 SHE3 PF17078.5 ETO15797.1 - 0.67 9.6 51.5 0.1 12.3 16.8 3.2 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DUF4795 PF16043.5 ETO15797.1 - 0.87 9.2 51.6 0.25 10.9 32.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Golgin_A5 PF09787.9 ETO15797.1 - 1.1 8.6 58.4 0.66 9.4 21.3 3.0 1 1 2 3 3 3 0 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 ETO15797.1 - 3.1 7.8 64.1 1.3 9.0 2.1 5.0 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Fez1 PF06818.15 ETO15797.1 - 3.7 8.0 50.9 0.41 11.1 12.9 2.8 1 1 1 2 2 2 0 Fez1 PvlArgDC PF01862.16 ETO15797.1 - 3.8 7.3 0.0 3.8 7.3 0.0 3.0 1 1 1 2 2 1 0 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) Bacillus_HBL PF05791.11 ETO15797.1 - 4.2 7.2 34.7 0.23 11.3 7.8 3.6 1 1 3 4 4 3 0 Bacillus haemolytic enterotoxin (HBL) Prominin PF05478.11 ETO15797.1 - 4.3 5.2 34.6 1.5 6.7 8.1 2.9 1 1 2 3 3 3 0 Prominin bZIP_1 PF00170.21 ETO15797.1 - 4.5 7.5 46.6 3.1 8.0 3.5 6.4 4 3 2 6 6 6 0 bZIP transcription factor ATG16 PF08614.11 ETO15797.1 - 4.5 7.4 60.9 1.6e+03 -0.9 38.4 3.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) EzrA PF06160.12 ETO15797.1 - 4.7 5.3 46.5 0.1 10.8 8.4 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Uso1_p115_C PF04871.13 ETO15797.1 - 4.9 7.5 54.4 0.57 10.5 11.3 3.9 1 1 2 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region FPP PF05911.11 ETO15797.1 - 5.9 5.0 55.3 0.078 11.2 14.8 2.9 1 1 1 2 2 1 0 Filament-like plant protein, long coiled-coil OmpH PF03938.14 ETO15797.1 - 5.9 7.2 54.3 3.9 7.8 16.1 3.4 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) T2SSF PF00482.23 ETO15797.1 - 9.5 6.2 10.6 0.73 9.8 0.8 3.3 3 1 0 3 3 3 0 Type II secretion system (T2SS), protein F SET PF00856.28 ETO15798.1 - 0.0024 18.3 0.2 0.0024 18.3 0.2 2.4 2 1 0 2 2 2 1 SET domain SabA_adhesion PF18304.1 ETO15798.1 - 0.0041 16.4 2.6 0.0059 15.9 0.2 2.0 1 1 1 2 2 2 1 SabA N-terminal extracellular adhesion domain Bin3 PF06859.12 ETO15798.1 - 0.043 14.4 2.6 5.1 7.8 0.4 2.8 2 0 0 2 2 2 0 Bicoid-interacting protein 3 (Bin3) HALZ PF02183.18 ETO15798.1 - 0.045 14.0 6.0 0.18 12.1 6.0 2.1 1 1 0 1 1 1 0 Homeobox associated leucine zipper Sec8_exocyst PF04048.14 ETO15799.1 - 4.3e-06 26.7 0.1 4.3e-06 26.7 0.1 2.4 2 1 1 3 3 3 1 Sec8 exocyst complex component specific domain Spore_coat_CotO PF14153.6 ETO15799.1 - 0.02 14.9 1.7 0.027 14.4 1.7 1.2 1 0 0 1 1 1 0 Spore coat protein CotO ER-remodelling PF14755.6 ETO15799.1 - 0.031 14.6 0.1 0.043 14.1 0.1 1.2 1 0 0 1 1 1 0 Intracellular membrane remodeller EFTUD2 PF16004.5 ETO15799.1 - 0.65 10.6 5.1 1.1 9.8 3.6 1.9 1 1 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Uds1 PF15456.6 ETO15799.1 - 5.8 7.1 10.3 46 4.2 0.1 2.7 2 1 0 2 2 2 0 Up-regulated During Septation Pkinase PF00069.25 ETO15800.1 - 2.6e-27 95.8 0.2 1.2e-26 93.7 0.0 2.1 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15800.1 - 1.2e-09 37.8 0.6 4.2e-09 36.1 0.0 2.1 3 0 0 3 3 3 1 Protein tyrosine kinase DUF2162 PF09930.9 ETO15800.1 - 0.02 14.3 0.0 0.031 13.7 0.0 1.2 1 0 0 1 1 1 0 Predicted transporter (DUF2162) LIM PF00412.22 ETO15801.1 - 0.22 11.8 9.1 0.12 12.6 5.4 2.4 2 0 0 2 2 2 0 LIM domain Filament PF00038.21 ETO15804.1 - 0.0013 18.4 1.7 0.0013 18.4 1.7 5.8 3 2 3 6 6 6 2 Intermediate filament protein MPS2 PF17060.5 ETO15804.1 - 0.0021 17.4 3.8 0.0021 17.4 3.8 3.5 3 1 1 4 4 4 1 Monopolar spindle protein 2 ATG16 PF08614.11 ETO15804.1 - 0.0042 17.3 17.3 0.0042 17.3 17.3 7.5 4 2 2 6 6 6 1 Autophagy protein 16 (ATG16) Pox_Ag35 PF03286.14 ETO15805.1 - 8.6 6.1 12.6 22 4.8 12.6 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PX PF00787.24 ETO15807.1 - 1.4e-10 41.1 0.3 2.9e-10 40.1 0.3 1.5 1 0 0 1 1 1 1 PX domain RRM_1 PF00076.22 ETO15807.1 - 0.0061 16.4 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-TRAF PF02176.18 ETO15808.1 - 2.4e-06 28.1 2.3 2.4e-06 28.1 2.3 2.5 2 0 0 2 2 2 1 TRAF-type zinc finger CDO_I PF05995.12 ETO15808.1 - 0.12 11.6 0.0 0.17 11.2 0.0 1.2 1 0 0 1 1 1 0 Cysteine dioxygenase type I PhoLip_ATPase_N PF16209.5 ETO15809.1 - 1.5e-24 85.5 2.3 2.9e-24 84.5 2.3 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Bac_export_2 PF01312.19 ETO15810.1 - 0.61 9.2 4.2 0.91 8.7 4.2 1.2 1 0 0 1 1 1 0 FlhB HrpN YscU SpaS Family ubiquitin PF00240.23 ETO15812.1 - 1.6e-05 24.5 0.1 1.6e-05 24.5 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin family PRP38_assoc PF12871.7 ETO15812.1 - 0.0012 19.4 52.8 0.0012 19.4 52.8 3.6 1 1 1 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Ubiquitin_2 PF14560.6 ETO15812.1 - 0.0034 17.8 0.1 0.0034 17.8 0.1 2.7 2 2 0 2 2 2 1 Ubiquitin-like domain Nuc_deoxyri_tr2 PF15891.5 ETO15812.1 - 0.13 12.6 3.6 0.5 10.7 3.2 2.3 1 1 0 1 1 1 0 Nucleoside 2-deoxyribosyltransferase like SOG2 PF10428.9 ETO15812.1 - 2.8 7.0 31.1 3.2 6.8 31.1 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Ribosomal_S25 PF03297.15 ETO15814.1 - 2.6e-29 101.4 6.8 2.6e-29 101.4 6.8 5.7 1 1 3 4 4 4 1 S25 ribosomal protein HTH_DeoR PF08220.12 ETO15814.1 - 0.018 14.8 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain dCMP_cyt_deam_1 PF00383.23 ETO15815.1 - 2.9e-08 33.5 0.6 5.6e-08 32.6 0.6 1.5 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETO15815.1 - 0.017 14.8 2.5 0.02 14.6 0.2 2.2 2 1 0 2 2 2 0 MafB19-like deaminase DUF4820 PF16091.5 ETO15816.1 - 0.0038 16.6 3.0 0.0054 16.1 3.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) Wzy_C PF04932.15 ETO15816.1 - 0.033 13.8 0.0 0.054 13.1 0.0 1.4 1 0 0 1 1 1 0 O-Antigen ligase PIEZO PF15917.5 ETO15816.1 - 0.1 12.1 3.4 0.56 9.7 0.1 2.2 2 0 0 2 2 2 0 Piezo DUF4834 PF16118.5 ETO15816.1 - 0.38 11.7 6.8 0.64 11.0 0.6 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) KCT2 PF17818.1 ETO15816.1 - 0.72 9.9 5.9 0.93 9.6 0.1 2.4 2 0 0 2 2 2 0 Keratinocyte-associated gene product Ran_BP1 PF00638.18 ETO15817.1 - 4.1e-09 36.8 1.3 1.1e-08 35.4 0.1 2.3 3 0 0 3 3 3 1 RanBP1 domain DUF4597 PF15366.6 ETO15817.1 - 0.069 12.9 0.0 0.14 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4597) WD40 PF00400.32 ETO15818.1 - 5.6e-54 178.9 17.9 1.9e-10 41.1 0.3 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15818.1 - 1.7e-17 63.5 1.6 9e-05 22.7 0.1 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15818.1 - 2.9e-13 49.5 0.8 0.26 10.2 0.0 6.3 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO15818.1 - 9.8e-08 31.1 5.2 0.53 8.9 0.0 4.8 2 2 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15818.1 - 3e-06 26.8 2.3 0.31 10.3 0.1 3.3 1 1 3 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO15818.1 - 9.4e-05 21.1 0.3 0.13 10.8 0.1 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO15818.1 - 0.0048 16.3 1.9 0.59 9.4 0.2 3.3 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal PQQ PF01011.21 ETO15818.1 - 0.016 15.1 0.0 4.5 7.4 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat LRR_5 PF13306.6 ETO15818.1 - 0.034 14.1 0.2 11 6.0 0.0 2.8 2 1 0 2 2 2 0 BspA type Leucine rich repeat region (6 copies) Cuticle_1 PF08140.11 ETO15818.1 - 0.17 12.0 0.0 80 3.4 0.0 3.6 3 0 0 3 3 3 0 Crustacean cuticle protein repeat PD40 PF07676.12 ETO15818.1 - 0.18 11.8 1.0 11 6.1 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO15822.1 - 0.0015 19.3 0.1 1.5 9.8 0.1 3.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15822.1 - 0.06 13.7 0.0 3.4 8.0 0.0 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain CDC45 PF02724.14 ETO15822.1 - 0.34 9.1 14.6 0.51 8.6 14.6 1.3 1 0 0 1 1 1 0 CDC45-like protein DAPDH_C PF16654.5 ETO15823.1 - 0.0094 15.8 1.2 0.014 15.3 1.2 1.2 1 0 0 1 1 1 1 Diaminopimelic acid dehydrogenase C-terminal domain ZapB PF06005.12 ETO15824.1 - 0.0039 17.6 7.1 0.0076 16.7 7.1 1.5 1 0 0 1 1 1 1 Cell division protein ZapB Cep57_CLD_2 PF14197.6 ETO15824.1 - 0.18 12.0 6.2 0.94 9.6 2.8 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 IATP PF04568.12 ETO15824.1 - 3.1 8.3 8.7 5.2 7.6 8.5 1.6 1 1 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP Roughex PF06020.11 ETO15825.1 - 0.018 14.1 23.1 0.021 13.9 23.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein CCSAP PF15748.5 ETO15825.1 - 0.084 13.0 28.2 0.11 12.7 28.2 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated CDC27 PF09507.10 ETO15825.1 - 0.12 11.8 36.1 0.14 11.5 36.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 GAGA_bind PF06217.12 ETO15825.1 - 0.13 12.5 18.1 0.19 12.0 18.1 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Nop14 PF04147.12 ETO15825.1 - 0.14 10.3 30.3 0.16 10.2 30.3 1.0 1 0 0 1 1 1 0 Nop14-like family GBP_C PF02841.14 ETO15825.1 - 0.46 9.8 29.2 0.6 9.5 29.2 1.3 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Merozoite_SPAM PF07133.11 ETO15825.1 - 0.84 9.6 42.7 1.3 9.0 42.7 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Asp-B-Hydro_N PF05279.11 ETO15825.1 - 0.87 9.6 32.3 1 9.4 32.3 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region XRN_M PF17846.1 ETO15825.1 - 1.3 7.9 19.4 1.4 7.8 19.4 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF4045 PF13254.6 ETO15825.1 - 1.8 8.1 29.0 2.2 7.8 29.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Raftlin PF15250.6 ETO15825.1 - 1.9 7.2 19.2 2.2 7.0 19.2 1.1 1 0 0 1 1 1 0 Raftlin MCM_bind PF09739.9 ETO15825.1 - 2.4 6.5 19.2 2.8 6.3 19.2 1.3 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 ETO15825.1 - 2.4 6.8 29.6 2.8 6.6 29.6 1.1 1 0 0 1 1 1 0 Presenilin Endostatin PF06482.11 ETO15825.1 - 3 7.2 13.9 3.6 7.0 13.9 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin POP1 PF06978.11 ETO15825.1 - 3 7.8 20.7 4.6 7.2 20.7 1.2 1 0 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 SpoIIIAH PF12685.7 ETO15825.1 - 3.1 7.6 30.2 4.5 7.0 30.2 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Macoilin PF09726.9 ETO15825.1 - 3.6 6.0 21.3 4.1 5.9 21.3 1.0 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 ETO15825.1 - 3.6 5.8 31.3 4.2 5.6 31.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 ETO15825.1 - 4.5 5.8 19.1 5 5.6 19.1 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator NARP1 PF12569.8 ETO15825.1 - 5.7 5.7 24.9 6.2 5.6 24.9 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CENP-N PF05238.13 ETO15825.1 - 5.8 6.1 18.9 6.9 5.9 18.9 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like PA26 PF04636.13 ETO15825.1 - 5.8 5.7 17.2 6.3 5.6 17.2 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SelP_N PF04592.14 ETO15825.1 - 6.4 6.1 16.8 8.1 5.8 16.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Neur_chan_memb PF02932.16 ETO15825.1 - 6.8 6.7 17.2 8.4 6.4 17.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MgsA_C PF12002.8 ETO15825.1 - 7.2 6.5 11.2 10 6.0 11.2 1.2 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal NPR3 PF03666.13 ETO15825.1 - 7.5 5.2 24.6 9.4 4.9 24.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Peptidase_S64 PF08192.11 ETO15825.1 - 7.6 4.9 17.3 8.2 4.8 17.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 LAP1C PF05609.12 ETO15825.1 - 8.3 5.4 24.7 9.6 5.2 24.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) ALMT PF11744.8 ETO15825.1 - 8.3 5.1 18.4 9.5 4.9 18.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter AAA_11 PF13086.6 ETO15825.1 - 9.5 5.9 23.7 12 5.6 23.7 1.2 1 0 0 1 1 1 0 AAA domain DivIC PF04977.15 ETO15826.1 - 0.045 13.5 2.4 0.045 13.5 2.4 2.4 3 0 0 3 3 3 0 Septum formation initiator ASD2 PF08687.11 ETO15826.1 - 4 6.9 23.5 10 5.6 21.3 2.1 1 1 1 2 2 2 0 Apx/Shroom domain ASD2 Macoilin PF09726.9 ETO15826.1 - 4.8 5.6 24.5 5.4 5.5 24.5 1.0 1 0 0 1 1 1 0 Macoilin family DASH_Spc19 PF08287.11 ETO15827.1 - 3.2 7.6 14.7 0.035 14.0 2.0 2.6 2 0 0 2 2 2 0 Spc19 EB1 PF03271.17 ETO15828.1 - 1.3e-09 38.1 1.9 3.2e-09 36.9 1.9 1.7 1 0 0 1 1 1 1 EB1-like C-terminal motif BAH PF01426.18 ETO15828.1 - 0.24 11.3 3.0 0.41 10.5 2.8 1.5 1 1 0 1 1 1 0 BAH domain MutS_V PF00488.21 ETO15829.1 - 1.2e-73 247.1 0.1 2.1e-73 246.4 0.1 1.4 1 0 0 1 1 1 1 MutS domain V MutS_III PF05192.18 ETO15829.1 - 4.8e-33 115.0 0.3 1.9e-32 113.1 0.3 2.1 1 0 0 1 1 1 1 MutS domain III MutS_I PF01624.20 ETO15829.1 - 4.3e-30 104.2 0.0 1.1e-29 103.0 0.0 1.7 1 0 0 1 1 1 1 MutS domain I MutS_II PF05188.17 ETO15829.1 - 4.5e-09 36.7 0.0 3.9e-08 33.7 0.0 2.4 2 0 0 2 2 2 1 MutS domain II MutS_IV PF05190.18 ETO15829.1 - 0.00019 21.7 0.1 0.00019 21.7 0.1 2.2 2 0 0 2 2 2 1 MutS family domain IV DUF3439 PF11921.8 ETO15829.1 - 0.96 9.4 4.3 27 4.8 1.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) UCH PF00443.29 ETO15830.1 - 9.6e-19 67.9 0.2 1.1e-18 67.6 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO15830.1 - 6.1e-17 62.2 0.2 7.1e-17 62.0 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Iso_dh PF00180.20 ETO15832.1 - 2.1e-05 23.9 0.0 2.8e-05 23.4 0.0 1.1 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase YajC PF02699.15 ETO15832.1 - 0.088 12.7 0.7 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 Preprotein translocase subunit DUF1115 PF06544.12 ETO15833.1 - 4.7e-15 56.0 0.7 5.7e-15 55.7 0.7 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1115) eIF-3c_N PF05470.12 ETO15834.1 - 2.8e-09 35.9 14.1 2.8e-09 35.9 14.1 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Ribosomal_L2_C PF03947.18 ETO15835.1 - 4.3e-39 133.6 0.7 5.8e-39 133.2 0.7 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain Ribosomal_L2 PF00181.23 ETO15835.1 - 6.9e-07 29.1 0.1 3e-06 27.1 0.0 2.1 2 1 0 2 2 2 1 Ribosomal Proteins L2, RNA binding domain DUF2671 PF10877.8 ETO15835.1 - 0.13 12.0 0.0 0.21 11.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2671) MAS20 PF02064.15 ETO15836.1 - 0.56 10.3 3.8 0.28 11.3 1.5 1.7 2 0 0 2 2 2 0 MAS20 protein import receptor DUF4770 PF15994.5 ETO15837.1 - 0.18 12.0 0.1 0.18 12.0 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4770) MSA-2c PF12238.8 ETO15838.1 - 0.57 10.1 7.3 1.6 8.7 7.3 1.7 1 0 0 1 1 1 0 Merozoite surface antigen 2c Tubulin_C PF03953.17 ETO15839.1 - 3.4e-43 146.8 0.1 5.2e-43 146.2 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO15839.1 - 3.8e-08 33.8 0.3 2.2e-07 31.3 0.1 2.1 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain DUF808 PF05661.12 ETO15840.1 - 0.015 14.4 0.1 0.49 9.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF808) Ni_hydr_CYTB PF01292.20 ETO15840.1 - 0.11 12.1 3.3 0.046 13.3 0.8 1.8 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 FAM176 PF14851.6 ETO15840.1 - 0.16 11.6 0.0 0.37 10.5 0.0 1.6 1 0 0 1 1 1 0 FAM176 family DUF2207 PF09972.9 ETO15840.1 - 0.68 8.6 5.1 3 6.5 1.2 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Gpr1_Fun34_YaaH PF01184.19 ETO15841.1 - 0.8 9.3 7.4 1.3 8.6 7.4 1.3 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family SH2_2 PF14633.6 ETO15843.1 - 0.0064 15.9 1.4 0.011 15.1 1.4 1.5 1 0 0 1 1 1 1 SH2 domain Hint_2 PF13403.6 ETO15843.1 - 0.13 12.6 0.0 0.2 11.9 0.0 1.3 1 0 0 1 1 1 0 Hint domain Hom_end_hint PF05203.16 ETO15843.1 - 0.17 11.8 0.7 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 Hom_end-associated Hint DivIC PF04977.15 ETO15843.1 - 1.2 8.9 5.1 1.3 8.9 3.6 1.8 2 0 0 2 2 2 0 Septum formation initiator Urease_alpha PF00449.20 ETO15844.1 - 0.022 15.1 0.1 0.031 14.6 0.1 1.2 1 0 0 1 1 1 0 Urease alpha-subunit, N-terminal domain FHA PF00498.26 ETO15845.1 - 4.3e-13 49.4 0.6 1.4e-12 47.8 0.1 1.9 2 0 0 2 2 2 1 FHA domain Yop-YscD_cpl PF16697.5 ETO15845.1 - 0.0052 17.1 0.1 0.012 15.9 0.1 1.7 1 1 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain ThiS PF02597.20 ETO15845.1 - 0.069 13.8 0.0 0.12 13.0 0.0 1.3 1 0 0 1 1 1 0 ThiS family FHA_2 PF17913.1 ETO15845.1 - 0.12 12.6 1.5 0.17 12.2 0.4 1.8 2 1 0 2 2 2 0 FHA domain Pkinase PF00069.25 ETO15846.1 - 2.8e-32 112.1 0.1 4.3e-32 111.5 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15846.1 - 2.5e-14 53.2 0.0 3.5e-14 52.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO15846.1 - 2.6e-05 23.7 0.3 4.9e-05 22.8 0.0 1.6 2 0 0 2 2 2 1 Kinase-like PPR_2 PF13041.6 ETO15847.1 - 0.1 12.8 1.1 0.24 11.6 1.1 1.6 1 0 0 1 1 1 0 PPR repeat family Ribosomal_S2 PF00318.20 ETO15849.1 - 0.66 9.2 9.0 1.2 8.4 9.0 1.3 1 0 0 1 1 1 0 Ribosomal protein S2 HTH_AsnC-type PF13404.6 ETO15850.1 - 0.013 15.4 0.1 0.024 14.5 0.1 1.4 1 0 0 1 1 1 0 AsnC-type helix-turn-helix domain Avl9 PF09794.9 ETO15850.1 - 0.056 12.1 0.1 0.07 11.8 0.1 1.1 1 0 0 1 1 1 0 Transport protein Avl9 Peptidase_M1 PF01433.20 ETO15851.1 - 6.2e-61 205.7 1.4 6.8e-61 205.6 1.4 1.0 1 0 0 1 1 1 1 Peptidase family M1 domain Aminopep PF10023.9 ETO15851.1 - 0.0015 18.0 0.2 0.004 16.6 0.0 1.7 2 0 0 2 2 2 1 Putative aminopeptidase Peptidase_M61 PF05299.12 ETO15851.1 - 0.18 12.2 1.3 10 6.5 1.3 2.6 1 1 0 1 1 1 0 M61 glycyl aminopeptidase ERAP1_C PF11838.8 ETO15852.1 - 1.2e-21 77.6 5.2 3.6e-20 72.7 5.2 2.1 1 1 0 1 1 1 1 ERAP1-like C-terminal domain Menin PF05053.13 ETO15853.1 - 0.029 12.8 11.1 0.033 12.6 11.1 1.1 1 0 0 1 1 1 0 Menin Flot PF15975.5 ETO15853.1 - 0.059 13.6 0.4 0.12 12.6 0.2 1.5 1 1 0 1 1 1 0 Flotillin Presenilin PF01080.17 ETO15853.1 - 8.1 5.1 6.1 9.6 4.8 6.1 1.1 1 0 0 1 1 1 0 Presenilin PT PF04886.12 ETO15855.1 - 3.5e-17 61.7 135.7 8.8e-05 22.0 13.4 7.4 2 2 3 5 5 5 3 PT repeat TBCC PF07986.12 ETO15856.1 - 4e-28 97.6 1.7 2.5e-18 66.0 0.1 2.1 2 0 0 2 2 2 2 Tubulin binding cofactor C DUF1430 PF07242.11 ETO15856.1 - 0.051 13.8 0.3 0.076 13.3 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1430) ETRAMP PF09716.10 ETO15856.1 - 0.18 11.9 1.4 0.27 11.3 1.4 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) tRNA-synt_1e PF01406.19 ETO15857.1 - 1.7e-11 44.0 1.7 2.9e-11 43.2 1.7 1.6 1 1 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain SLATT_5 PF18160.1 ETO15857.1 - 0.0073 15.7 1.3 0.013 14.8 1.3 1.4 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain family 5 tRNA-synt_1c PF00749.21 ETO15857.1 - 0.008 15.1 0.1 0.008 15.1 0.1 1.8 2 0 0 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain DUF508 PF04370.12 ETO15858.1 - 2.2 8.0 12.6 7.2 6.3 12.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF508) G-alpha PF00503.20 ETO15859.1 - 4.6e-10 39.2 0.9 2.4e-06 27.0 0.1 2.9 1 1 1 2 2 2 2 G-protein alpha subunit SPRY PF00622.28 ETO15860.1 - 0.015 15.4 0.3 0.015 15.4 0.3 2.2 2 0 0 2 2 2 0 SPRY domain fn3 PF00041.21 ETO15860.1 - 0.15 12.4 0.1 0.87 10.0 0.0 2.3 2 0 0 2 2 2 0 Fibronectin type III domain Presenilin PF01080.17 ETO15860.1 - 0.39 9.4 16.2 0.6 8.8 16.2 1.3 1 0 0 1 1 1 0 Presenilin DASH_Dad2 PF08654.10 ETO15860.1 - 5.1 7.6 11.3 13 6.3 3.0 2.4 2 0 0 2 2 2 0 DASH complex subunit Dad2 p450 PF00067.22 ETO15861.1 - 1.7e-50 172.1 0.0 1.9e-50 172.0 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ETO15862.1 - 2.2e-08 33.3 0.5 2.6e-08 33.1 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 Intein_splicing PF14890.6 ETO15863.1 - 1e-08 35.2 0.2 4.1e-08 33.3 0.2 1.9 1 1 0 1 1 1 1 Intein splicing domain Hint PF01079.20 ETO15863.1 - 3.2e-08 33.4 0.0 5.6e-08 32.6 0.0 1.3 1 0 0 1 1 1 1 Hint module PT-HINT PF07591.11 ETO15863.1 - 8.6e-05 22.8 0.3 0.00063 20.0 0.4 2.3 2 1 0 2 2 2 1 Pretoxin HINT domain AXH PF08517.12 ETO15863.1 - 0.0046 17.5 0.0 0.0098 16.4 0.0 1.6 1 0 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) Asp_decarbox PF02261.16 ETO15863.1 - 0.0091 15.9 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Aspartate decarboxylase Zn_Tnp_IS1595 PF12760.7 ETO15863.1 - 0.022 14.7 3.0 0.073 13.1 3.0 1.9 1 0 0 1 1 1 0 Transposase zinc-ribbon domain Hom_end_hint PF05203.16 ETO15863.1 - 0.056 13.4 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Hom_end-associated Hint DUF4202 PF13875.6 ETO15863.1 - 0.089 12.7 0.2 0.15 12.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4202) PI3K_rbd PF00794.18 ETO15864.1 - 1.7e-05 24.9 0.2 4.3e-05 23.6 0.2 1.6 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain EPL1 PF10513.9 ETO15865.1 - 0.0057 17.1 4.2 0.0073 16.7 4.2 1.1 1 0 0 1 1 1 1 Enhancer of polycomb-like Vfa1 PF08432.10 ETO15865.1 - 0.053 13.9 14.2 0.075 13.4 14.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 YL1 PF05764.13 ETO15865.1 - 0.23 11.5 18.3 0.046 13.8 15.3 1.4 2 0 0 2 2 2 0 YL1 nuclear protein NPR3 PF03666.13 ETO15865.1 - 0.23 10.2 7.6 0.21 10.4 7.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SKA1 PF07160.12 ETO15865.1 - 0.48 10.2 12.0 0.71 9.7 12.0 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 CDC45 PF02724.14 ETO15865.1 - 1.3 7.2 6.6 1.4 7.1 6.6 1.1 1 0 0 1 1 1 0 CDC45-like protein TP53IP5 PF15331.6 ETO15865.1 - 2.2 8.4 14.4 8.3 6.5 0.0 2.0 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 Tim54 PF11711.8 ETO15865.1 - 3.2 6.4 12.2 0.71 8.6 9.2 1.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Connexin PF00029.19 ETO15865.1 - 3.7 7.2 9.6 4.8 6.9 9.6 1.2 1 0 0 1 1 1 0 Connexin MCM_bind PF09739.9 ETO15865.1 - 5.6 5.3 9.1 6.4 5.1 9.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Presenilin PF01080.17 ETO15865.1 - 9.1 4.9 5.8 11 4.7 5.8 1.1 1 0 0 1 1 1 0 Presenilin Fez1 PF06818.15 ETO15866.1 - 0.045 14.2 13.4 0.064 13.7 13.4 1.2 1 0 0 1 1 1 0 Fez1 Golgin_A5 PF09787.9 ETO15866.1 - 0.052 13.0 11.8 0.065 12.7 11.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 Bcr-Abl_Oligo PF09036.10 ETO15866.1 - 0.22 11.6 9.7 0.45 10.6 4.0 3.0 1 1 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain CCDC-167 PF15188.6 ETO15866.1 - 0.35 11.2 11.2 0.29 11.5 8.9 2.0 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 TPR_MLP1_2 PF07926.12 ETO15866.1 - 0.43 10.6 17.0 1.8 8.6 16.0 2.0 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein ABC_tran_CTD PF16326.5 ETO15866.1 - 0.74 10.1 13.2 1.1 9.6 5.6 2.9 2 1 1 3 3 3 0 ABC transporter C-terminal domain FlxA PF14282.6 ETO15866.1 - 1.7 8.7 15.1 2.5 8.2 11.5 2.3 1 1 1 2 2 2 0 FlxA-like protein Fib_alpha PF08702.10 ETO15866.1 - 1.9 8.7 11.1 1.9 8.7 9.8 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF5339 PF17274.2 ETO15866.1 - 2.2 9.2 7.6 14 6.6 0.6 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5339) APG6_N PF17675.1 ETO15866.1 - 3.8 8.0 17.0 4.8 7.7 12.8 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region Spc7 PF08317.11 ETO15866.1 - 4 6.2 17.2 6.4 5.6 17.2 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF4140 PF13600.6 ETO15866.1 - 5.4 7.5 12.5 5.1 7.6 0.2 3.1 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) LMBR1 PF04791.16 ETO15866.1 - 7.1 5.4 5.2 8.8 5.1 5.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3450 PF11932.8 ETO15866.1 - 8.1 5.7 14.3 1.7 7.9 9.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF2203 PF09969.9 ETO15866.1 - 9 7.0 9.0 4.2 8.1 5.8 1.8 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) Spindle_Spc25 PF08234.12 ETO15867.1 - 2.8e-18 65.9 1.6 1.6e-17 63.5 0.2 2.3 2 0 0 2 2 2 1 Chromosome segregation protein Spc25 EzrA PF06160.12 ETO15867.1 - 0.00063 18.0 10.8 0.017 13.3 4.8 2.0 2 0 0 2 2 2 2 Septation ring formation regulator, EzrA FliJ PF02050.16 ETO15867.1 - 0.1 12.9 11.4 0.11 12.7 1.5 2.9 2 1 1 3 3 3 0 Flagellar FliJ protein Med21 PF11221.8 ETO15867.1 - 0.22 11.8 6.2 0.85 9.9 0.3 2.8 1 1 2 3 3 3 0 Subunit 21 of Mediator complex Remorin_C PF03763.13 ETO15867.1 - 0.76 9.7 6.5 0.18 11.7 3.0 1.7 2 0 0 2 2 2 0 Remorin, C-terminal region GrpE PF01025.19 ETO15867.1 - 1 9.0 9.3 1.6 8.4 3.1 2.4 2 1 0 2 2 2 0 GrpE Prefoldin_2 PF01920.20 ETO15867.1 - 4 7.4 13.4 1.9 8.5 3.7 3.1 2 1 0 2 2 2 0 Prefoldin subunit FapA PF03961.13 ETO15867.1 - 6.4 5.3 8.8 9 4.8 4.3 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4131 PF13567.6 ETO15868.1 - 0.0021 17.8 0.3 0.004 16.8 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) Pox_E10 PF04805.12 ETO15870.1 - 0.0059 16.4 4.4 0.0059 16.4 4.4 2.5 1 1 1 2 2 2 1 E10-like protein conserved region BTB_3 PF16017.5 ETO15870.1 - 0.056 13.5 0.4 0.097 12.8 0.4 1.3 1 0 0 1 1 1 0 BTB/POZ domain MAM1 PF10434.9 ETO15871.1 - 0.02 14.5 1.0 0.021 14.4 1.0 1.1 1 0 0 1 1 1 0 Monopolin complex protein MAM1 Noelin-1 PF12308.8 ETO15871.1 - 0.094 12.7 1.5 0.17 11.9 1.4 1.5 1 1 0 1 1 1 0 Neurogenesis glycoprotein FH2 PF02181.23 ETO15872.1 - 1.1e-14 54.3 0.7 2.3e-14 53.3 0.0 1.8 2 0 0 2 2 2 1 Formin Homology 2 Domain bZIP_1 PF00170.21 ETO15872.1 - 0.00072 19.6 4.1 0.0033 17.5 4.1 2.2 1 0 0 1 1 1 1 bZIP transcription factor DUF2681 PF10883.8 ETO15872.1 - 0.13 12.7 9.9 1.5 9.3 1.5 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) UPF0242 PF06785.11 ETO15872.1 - 5.1 7.1 8.8 0.55 10.3 0.4 3.0 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 ETO15872.1 - 8.2 6.3 7.4 0.45 10.3 0.9 2.3 2 0 0 2 2 2 0 Septum formation initiator RPEL PF02755.15 ETO15873.1 - 0.0011 18.6 5.9 0.0023 17.6 5.9 1.6 1 0 0 1 1 1 1 RPEL repeat UCH PF00443.29 ETO15873.1 - 0.096 12.2 13.2 0.14 11.6 13.2 1.3 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase Sdh_cyt PF01127.22 ETO15874.1 - 6.8e-05 22.9 3.3 6.8e-05 22.9 3.3 2.7 3 0 0 3 3 3 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit DUF1691 PF07950.11 ETO15874.1 - 0.0081 16.9 0.5 0.0081 16.9 0.5 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1691) Ni_hydr_CYTB PF01292.20 ETO15874.1 - 1.4 8.5 11.9 0.13 11.9 1.0 2.9 2 2 1 3 3 3 0 Prokaryotic cytochrome b561 WD40 PF00400.32 ETO15875.1 - 3.6e-67 220.7 26.1 5.4e-11 42.9 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO15875.1 - 2e-19 69.7 0.7 0.0081 15.2 0.0 6.3 2 2 5 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO15875.1 - 1.7e-18 66.7 3.0 0.00098 19.4 0.0 6.4 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO15875.1 - 2e-11 44.2 0.1 1.3e-05 25.2 0.0 3.3 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO15875.1 - 2.6e-05 23.1 6.1 0.012 14.3 0.1 4.2 2 1 1 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO15875.1 - 4.4e-05 22.2 0.8 0.0015 17.1 0.1 2.9 2 1 0 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO15875.1 - 0.00088 18.7 0.7 0.28 10.5 0.0 3.7 1 1 3 4 4 4 1 WD40-like domain Nbas_N PF15492.6 ETO15875.1 - 0.0011 18.4 2.2 3 7.1 0.0 3.9 2 1 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO15875.1 - 0.043 12.5 5.8 1 8.0 0.2 4.0 2 1 3 5 5 5 0 Nup133 N terminal like PD40 PF07676.12 ETO15875.1 - 0.066 13.2 13.3 3.1 7.9 0.1 5.5 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat LydB PF16084.5 ETO15875.1 - 0.084 12.7 0.1 0.33 10.8 0.0 1.9 2 1 1 3 3 3 0 LydA-holin antagonist WD40 PF00400.32 ETO15876.1 - 1.1e-30 105.2 6.3 1.1e-11 45.0 0.0 3.6 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15876.1 - 1.4e-11 44.5 0.3 3e-05 24.2 0.1 3.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO15876.1 - 7.5e-08 32.0 0.1 2.1e-07 30.6 0.1 1.7 1 1 1 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 ETO15876.1 - 3.5e-05 22.9 0.1 0.025 13.6 0.0 2.8 1 1 2 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO15876.1 - 0.0004 20.3 0.0 2.3 8.2 0.0 3.2 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO15876.1 - 0.0046 15.7 0.1 1.2 7.7 0.0 2.3 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO15876.1 - 0.0075 15.1 1.8 0.8 8.4 0.1 2.5 1 1 1 2 2 2 2 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO15876.1 - 0.013 14.6 0.1 0.015 14.4 0.1 1.1 1 0 0 1 1 1 0 Coatomer WD associated region BBS2_Mid PF14783.6 ETO15876.1 - 0.013 15.5 0.3 0.22 11.6 0.1 2.7 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, middle region MecA_N PF05223.11 ETO15877.1 - 0.073 13.3 7.5 0.057 13.7 5.1 1.9 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain PGA2 PF07543.12 ETO15877.1 - 0.088 12.8 7.2 0.15 12.1 7.2 1.4 1 0 0 1 1 1 0 Protein trafficking PGA2 YqfQ PF14181.6 ETO15877.1 - 6.8 6.8 14.6 3.5 7.8 11.5 1.9 2 0 0 2 2 2 0 YqfQ-like protein Yae1_N PF09811.9 ETO15879.1 - 0.0054 16.4 6.3 0.015 15.0 6.3 1.7 1 1 0 1 1 1 1 Essential protein Yae1, N terminal Pkinase_C PF00433.24 ETO15880.1 - 0.015 16.0 0.1 0.064 14.0 0.1 2.0 1 1 0 1 1 1 0 Protein kinase C terminal domain Ribosomal_60s PF00428.19 ETO15881.1 - 5.2 7.7 11.7 12 6.6 11.7 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein DDE_3 PF13358.6 ETO15882.1 - 8e-11 41.9 0.5 9.4e-11 41.7 0.5 1.1 1 0 0 1 1 1 1 DDE superfamily endonuclease COG6 PF06419.11 ETO15882.1 - 0.026 12.8 0.1 0.029 12.6 0.1 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 Ion_trans PF00520.31 ETO15883.1 - 1.2e-87 293.2 44.2 6.8e-37 127.0 6.1 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 ETO15883.1 - 3.3e-05 22.8 11.3 3.3e-05 22.8 11.3 5.8 4 2 2 6 6 6 4 Polycystin cation channel ISK_Channel PF02060.15 ETO15883.1 - 0.025 14.3 4.1 0.35 10.6 0.0 3.6 3 0 0 3 3 3 0 Slow voltage-gated potassium channel Nsp3_PL2pro PF12124.8 ETO15884.1 - 0.033 14.0 0.3 0.96 9.3 0.1 2.3 2 0 0 2 2 2 0 Coronavirus polyprotein cleavage domain DUF2621 PF11084.8 ETO15885.1 - 0.1 12.6 0.2 2.7 8.0 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2621) OSCP PF00213.18 ETO15885.1 - 1.8 8.7 5.0 5 7.2 0.2 3.2 4 0 0 4 4 4 0 ATP synthase delta (OSCP) subunit HSP70 PF00012.20 ETO15887.1 - 4.4e-07 28.5 0.0 0.0041 15.4 0.0 2.3 1 1 0 2 2 2 2 Hsp70 protein IMUP PF15761.5 ETO15887.1 - 0.093 13.4 2.2 0.28 11.9 2.2 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF3800 PF12686.7 ETO15887.1 - 3.7 8.2 6.4 0.66 10.6 0.6 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF3800) DUF2714 PF10896.8 ETO15888.1 - 0.0075 16.3 0.1 0.013 15.5 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2714) DUF5454 PF17535.2 ETO15888.1 - 0.044 13.2 0.2 0.073 12.4 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5454) Suc_Fer-like PF06999.12 ETO15888.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.4 1 1 0 1 1 1 0 Sucrase/ferredoxin-like SWI-SNF_Ssr4 PF08549.10 ETO15889.1 - 0.02 13.6 17.3 0.026 13.2 17.3 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PTPlike_phytase PF14566.6 ETO15889.1 - 0.32 11.1 6.5 0.053 13.6 1.2 2.1 2 0 0 2 2 2 0 Inositol hexakisphosphate LVIVD PF08309.11 ETO15890.1 - 2.2e-44 148.5 36.1 4.7e-05 22.6 0.1 12.5 12 0 0 12 12 12 11 LVIVD repeat He_PIG PF05345.12 ETO15890.1 - 4.9e-20 71.4 13.3 9.9e-07 28.8 2.0 6.0 5 0 0 5 5 5 4 Putative Ig domain DUF4200 PF13863.6 ETO15890.1 - 1.9e-09 38.0 17.5 1.9e-09 38.0 17.5 3.3 2 2 1 4 4 4 1 Domain of unknown function (DUF4200) Pkinase PF00069.25 ETO15891.1 - 1.6e-13 50.6 0.1 1.6e-13 50.6 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO15891.1 - 3.2e-08 33.2 0.7 7.8e-08 31.9 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Apt1 PF10351.9 ETO15891.1 - 0.007 15.3 6.4 0.0069 15.3 6.4 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Ndc1_Nup PF09531.10 ETO15891.1 - 0.068 11.9 3.9 0.066 11.9 3.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ETO15891.1 - 0.11 11.3 7.6 0.12 11.1 7.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO15891.1 - 0.13 10.6 8.1 0.15 10.3 8.1 1.1 1 0 0 1 1 1 0 CDC45-like protein XAP5 PF04921.14 ETO15891.1 - 0.14 11.9 9.8 0.22 11.3 9.8 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator FAM220 PF15487.6 ETO15891.1 - 0.18 11.4 9.7 0.24 11.0 9.7 1.1 1 0 0 1 1 1 0 FAM220 family Sec62 PF03839.16 ETO15891.1 - 0.24 10.9 5.8 0.31 10.5 5.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 ETO15891.1 - 0.34 10.7 6.9 0.42 10.4 6.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DHHW PF14286.6 ETO15891.1 - 0.35 10.1 6.9 0.51 9.6 6.9 1.2 1 0 0 1 1 1 0 DHHW protein Zip PF02535.22 ETO15891.1 - 0.6 9.3 3.6 0.65 9.2 3.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO15891.1 - 0.76 9.8 6.7 1 9.4 6.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Spt20 PF12090.8 ETO15891.1 - 0.81 9.3 17.7 1.1 8.8 17.7 1.1 1 0 0 1 1 1 0 Spt20 family adh_short_C2 PF13561.6 ETO15893.1 - 0.0076 15.8 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase ketoacyl-synt PF00109.26 ETO15894.1 - 4.4e-28 98.5 0.7 7.1e-28 97.9 0.7 1.3 1 0 0 1 1 1 1 Beta-ketoacyl synthase, N-terminal domain Ketoacyl-synt_C PF02801.22 ETO15894.1 - 3e-24 85.3 0.2 3e-24 85.3 0.2 2.3 2 1 0 2 2 2 1 Beta-ketoacyl synthase, C-terminal domain Thiolase_N PF00108.23 ETO15894.1 - 0.0067 15.8 1.2 0.012 15.0 1.2 1.3 1 0 0 1 1 1 1 Thiolase, N-terminal domain PhoLip_ATPase_C PF16212.5 ETO15895.1 - 3.9e-57 193.9 25.9 4.9e-57 193.6 25.9 1.0 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase_3 PF08282.12 ETO15895.1 - 0.0011 18.7 0.7 0.0019 18.0 0.7 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETO15896.1 - 1e-08 35.7 0.0 1.3e-08 35.4 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO15896.1 - 3.1e-08 33.6 1.2 3e-07 30.4 0.1 2.7 2 1 0 2 2 2 1 Cation transport ATPase (P-type) NDUF_B6 PF09782.9 ETO15896.1 - 0.048 13.8 1.0 0.14 12.3 0.2 1.9 2 0 0 2 2 2 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit TraG_N PF07916.11 ETO15896.1 - 0.12 11.3 0.3 0.19 10.5 0.2 1.3 1 1 0 1 1 1 0 TraG-like protein, N-terminal region CLZ PF16526.5 ETO15896.1 - 2.8 8.4 7.9 16 5.9 0.3 2.9 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tim54 PF11711.8 ETO15897.1 - 0.066 12.0 5.4 0.097 11.4 5.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4746 PF15928.5 ETO15897.1 - 0.83 9.0 17.7 0.91 8.9 17.2 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4746) SprA-related PF12118.8 ETO15897.1 - 3 6.9 13.5 3.5 6.7 13.5 1.1 1 0 0 1 1 1 0 SprA-related family RRM_3 PF08777.11 ETO15897.1 - 3.2 7.9 9.9 0.17 11.9 2.9 2.2 1 1 1 2 2 2 0 RNA binding motif Cadherin_C_2 PF16492.5 ETO15897.1 - 3.9 8.3 6.4 16 6.3 6.4 2.0 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal Presenilin PF01080.17 ETO15897.1 - 5.1 5.8 7.7 6.1 5.5 7.7 1.2 1 0 0 1 1 1 0 Presenilin Androgen_recep PF02166.16 ETO15897.1 - 5.8 5.6 7.5 7.1 5.3 7.5 1.1 1 0 0 1 1 1 0 Androgen receptor Mucin PF01456.17 ETO15898.1 - 0.0028 17.6 12.6 0.0028 17.6 12.6 3.5 3 1 0 3 3 3 3 Mucin-like glycoprotein PPR_2 PF13041.6 ETO15899.1 - 0.0099 16.1 3.2 10 6.4 0.0 4.6 5 0 0 5 5 5 1 PPR repeat family PPR PF01535.20 ETO15899.1 - 0.015 15.5 2.3 0.28 11.5 0.0 3.7 4 0 0 4 4 4 0 PPR repeat PRC2_HTH_1 PF18118.1 ETO15899.1 - 0.091 13.6 0.8 0.72 10.7 0.0 2.7 2 1 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain ATP-synt_A PF00119.20 ETO15901.1 - 0.51 10.3 10.9 0.071 13.1 6.8 1.6 2 0 0 2 2 2 0 ATP synthase A chain DUF2070 PF09843.9 ETO15902.1 - 0.4 8.9 9.5 0.5 8.6 9.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) MBOAT PF03062.19 ETO15903.1 - 4.4e-27 95.3 10.6 5.6e-27 95.0 10.6 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Coilin_N PF15862.5 ETO15905.1 - 0.035 13.9 7.7 0.077 12.8 7.7 1.6 1 0 0 1 1 1 0 Coilin N-terminus DUF3391 PF11871.8 ETO15905.1 - 0.081 13.5 3.4 0.13 12.8 3.4 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) DUF4629 PF15442.6 ETO15906.1 - 0.38 11.0 5.8 0.22 11.8 3.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4629) Microtub_bind PF13931.6 ETO15906.1 - 3.1 8.2 11.4 4.3 7.7 10.3 1.7 1 1 1 2 2 2 0 Kinesin-associated microtubule-binding SARAF PF06682.12 ETO15907.1 - 0.027 14.1 1.3 0.054 13.2 1.3 1.6 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Orf78 PF06024.12 ETO15907.1 - 0.12 12.7 2.7 0.35 11.2 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) DUF5542 PF17696.1 ETO15907.1 - 0.21 11.7 0.1 0.21 11.7 0.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5542) Secretin_N_2 PF07655.13 ETO15907.1 - 0.45 11.1 5.0 8.3 7.0 0.0 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain ETRAMP PF09716.10 ETO15908.1 - 0.0032 17.5 0.5 0.0032 17.5 0.5 3.7 3 1 0 3 3 3 1 Malarial early transcribed membrane protein (ETRAMP) SARAF PF06682.12 ETO15908.1 - 0.0037 17.0 0.9 0.23 11.1 0.1 2.3 2 0 0 2 2 2 1 SOCE-associated regulatory factor of calcium homoeostasis SLX9 PF15341.6 ETO15908.1 - 0.0049 17.3 0.0 0.0049 17.3 0.0 2.8 3 2 0 3 3 3 1 Ribosome biogenesis protein SLX9 Thioredoxin PF00085.20 ETO15908.1 - 0.019 15.0 0.1 0.052 13.5 0.1 1.8 1 0 0 1 1 1 0 Thioredoxin Syntaxin-6_N PF09177.11 ETO15908.1 - 0.099 13.2 14.5 0.32 11.6 0.0 3.7 3 2 1 4 4 4 0 Syntaxin 6, N-terminal Importin_rep_6 PF18829.1 ETO15908.1 - 0.28 11.3 6.2 0.17 12.0 0.3 3.1 3 0 0 3 3 3 0 Importin repeat 6 APP_E2 PF12925.7 ETO15908.1 - 1.2 8.8 15.5 0.053 13.2 2.7 2.6 3 0 0 3 3 3 0 E2 domain of amyloid precursor protein Ac76 PF05814.11 ETO15908.1 - 2.7 8.1 11.2 5.9 7.0 1.1 4.1 3 0 0 3 3 3 0 Orf76 (Ac76) H-kinase_dim PF02895.14 ETO15908.1 - 2.9 8.4 9.7 0.73 10.3 4.0 2.7 3 0 0 3 3 3 0 Signal transducing histidine kinase, homodimeric domain Striatin PF08232.12 ETO15908.1 - 3.2 8.3 16.8 1.1 9.8 7.4 2.6 2 0 0 2 2 2 0 Striatin family WXG100 PF06013.12 ETO15908.1 - 4.7 7.5 6.1 15 5.9 1.8 3.7 4 1 0 4 4 4 0 Proteins of 100 residues with WXG DUF4407 PF14362.6 ETO15908.1 - 9.4 5.5 14.6 6.7 6.0 0.1 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4407) ABC_tran PF00005.27 ETO15909.1 - 0.00058 20.4 0.0 0.00058 20.4 0.0 3.8 3 1 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 ETO15909.1 - 0.0025 17.7 0.2 0.0025 17.7 0.2 3.3 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 ETO15909.1 - 0.0055 16.4 0.1 0.012 15.3 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 ETO15909.1 - 0.0073 15.4 0.1 0.02 14.0 0.1 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein DUF3426 PF11906.8 ETO15909.1 - 0.016 15.3 0.1 0.096 12.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3426) AAA_19 PF13245.6 ETO15909.1 - 0.019 15.3 1.5 0.21 11.9 0.0 3.1 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ETO15909.1 - 0.064 13.5 0.0 0.35 11.1 0.0 2.4 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETO15909.1 - 0.065 13.3 0.1 0.065 13.3 0.1 3.9 4 1 0 4 4 4 0 50S ribosome-binding GTPase AAA_16 PF13191.6 ETO15909.1 - 0.11 12.9 0.7 0.9 9.9 0.0 3.0 3 1 0 3 3 3 0 AAA ATPase domain AAA PF00004.29 ETO15909.1 - 0.26 11.7 9.3 8 6.9 0.0 4.4 4 0 0 4 4 3 0 ATPase family associated with various cellular activities (AAA) Mating_N PF12731.7 ETO15909.1 - 0.49 10.5 8.3 14 5.9 2.3 3.8 2 0 0 2 2 2 0 Mating-type protein beta 1 YflT PF11181.8 ETO15909.1 - 1.5 9.3 7.0 8.7 6.9 0.1 3.6 2 0 0 2 2 2 0 Heat induced stress protein YflT Ribosomal_60s PF00428.19 ETO15910.1 - 0.064 13.8 9.1 0.11 13.1 9.1 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein TFIIF_alpha PF05793.12 ETO15910.1 - 0.069 11.7 19.8 0.08 11.5 19.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ETO15910.1 - 0.072 11.2 8.8 0.073 11.2 8.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Phage-MuB_C PF09077.11 ETO15910.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Mu B transposition protein, C terminal CBF PF03914.17 ETO15910.1 - 0.19 11.7 1.5 0.29 11.1 1.5 1.3 1 0 0 1 1 1 0 CBF/Mak21 family RR_TM4-6 PF06459.12 ETO15910.1 - 0.5 10.1 12.6 0.57 10.0 12.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PBP1_TM PF14812.6 ETO15910.1 - 1.4 9.4 6.4 2.6 8.5 6.4 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Macoilin PF09726.9 ETO15910.1 - 1.9 6.9 14.2 2.2 6.7 14.2 1.0 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 ETO15910.1 - 2.7 6.2 13.0 2.8 6.1 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF778 PF05608.12 ETO15910.1 - 5.1 7.4 9.1 7.2 6.9 9.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF778) GlcNAc PF11397.8 ETO15911.1 - 2e-49 168.9 0.0 2.4e-49 168.7 0.0 1.0 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) Kelch_6 PF13964.6 ETO15912.1 - 0.00036 20.7 0.5 0.00036 20.7 0.5 2.7 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO15912.1 - 0.018 15.1 1.4 0.038 14.0 0.5 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO15912.1 - 0.018 15.0 1.0 0.018 15.0 1.0 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO15912.1 - 0.057 13.0 1.3 0.057 13.0 1.3 1.8 2 0 0 2 2 2 0 Kelch motif Orthoreo_P10 PF07204.11 ETO15912.1 - 0.087 12.8 0.0 3.6 7.6 0.0 2.4 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 DUF1180 PF06679.12 ETO15912.1 - 5.1 7.5 5.7 7.8 6.9 5.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) EF-hand_5 PF13202.6 ETO15913.1 - 0.0015 17.9 0.0 0.0042 16.5 0.0 1.7 1 0 0 1 1 1 1 EF hand TT1725 PF18324.1 ETO15913.1 - 0.031 14.4 0.1 0.072 13.2 0.1 1.6 1 0 0 1 1 1 0 Hypothetical protein TT1725 DUF2207 PF09972.9 ETO15913.1 - 0.057 12.2 1.4 0.1 11.4 1.4 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EF-hand_1 PF00036.32 ETO15913.1 - 0.14 11.7 0.1 0.5 10.0 0.1 1.9 1 0 0 1 1 1 0 EF hand MgtE_N PF03448.17 ETO15913.1 - 1.3 9.7 3.7 1.8 9.2 0.4 2.8 3 0 0 3 3 3 0 MgtE intracellular N domain FliG_N PF14842.6 ETO15913.1 - 2.1 8.9 5.4 0.73 10.4 1.3 2.4 3 0 0 3 3 3 0 FliG N-terminal domain TMEM208_SND2 PF05620.11 ETO15914.1 - 0.12 12.2 0.1 0.21 11.4 0.1 1.4 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 BRE1 PF08647.11 ETO15916.1 - 0.011 15.7 15.0 0.011 15.7 15.0 9.7 5 3 3 9 9 9 0 BRE1 E3 ubiquitin ligase FlaC_arch PF05377.11 ETO15916.1 - 0.089 13.2 0.2 0.089 13.2 0.2 10.0 12 1 0 12 12 12 0 Flagella accessory protein C (FlaC) LOB PF03195.14 ETO15916.1 - 0.3 11.7 4.0 0.6 10.7 0.1 3.6 3 0 0 3 3 3 0 Lateral organ boundaries (LOB) domain G-alpha PF00503.20 ETO15917.1 - 2.3e-89 300.0 7.9 3e-89 299.7 7.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO15917.1 - 1.9e-13 50.2 0.8 5.5e-10 39.0 0.5 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO15917.1 - 0.00021 21.5 0.1 0.48 10.7 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ETO15917.1 - 0.00052 19.4 4.3 0.017 14.5 0.4 2.4 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region TniB PF05621.11 ETO15917.1 - 0.00076 18.9 0.1 0.0016 17.9 0.1 1.5 1 0 0 1 1 1 1 Bacterial TniB protein dNK PF01712.19 ETO15917.1 - 0.0081 16.0 0.0 0.018 14.9 0.0 1.5 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_22 PF13401.6 ETO15917.1 - 0.044 14.0 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO15917.1 - 0.059 12.7 0.0 0.2 11.0 0.0 1.9 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_29 PF13555.6 ETO15917.1 - 0.12 12.2 0.0 0.34 10.7 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain TPR_21 PF09976.9 ETO15917.1 - 0.16 11.7 0.4 0.59 9.8 0.0 2.1 3 0 0 3 3 3 0 Tetratricopeptide repeat-like domain Acyl-CoA_ox_N PF14749.6 ETO15917.1 - 0.59 10.7 4.6 1.3 9.6 0.4 2.8 3 0 0 3 3 3 0 Acyl-coenzyme A oxidase N-terminal DUF3586 PF12131.8 ETO15918.1 - 0.017 15.3 9.6 0.5 10.6 3.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3586) Cas_Cas5d PF09704.10 ETO15919.1 - 0.27 11.1 1.7 0.58 10.0 1.7 1.5 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cas5) Cse1 PF08506.10 ETO15921.1 - 8.1e-15 54.5 2.6 3.5e-14 52.4 2.6 2.0 1 1 0 1 1 1 1 Cse1 zf-C2H2_4 PF13894.6 ETO15922.1 - 0.00047 20.8 2.1 0.00047 20.8 2.1 2.7 2 1 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO15922.1 - 0.00068 20.0 2.2 0.00068 20.0 2.2 2.6 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO15922.1 - 0.21 12.1 13.1 1.5 9.4 3.1 3.2 3 0 0 3 3 3 0 Zinc-finger double domain DSPc PF00782.20 ETO15923.1 - 7.9e-31 106.6 0.5 1.1e-30 106.2 0.5 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO15923.1 - 1.2e-05 25.1 0.2 1.3e-05 24.9 0.2 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETO15923.1 - 0.00011 22.3 0.0 0.00015 21.9 0.0 1.2 1 0 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 ETO15923.1 - 0.0026 18.0 0.3 0.0062 16.8 0.3 1.8 1 1 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase3 PF13350.6 ETO15923.1 - 0.16 11.9 0.0 0.2 11.6 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family zf-UBR PF02207.20 ETO15925.1 - 4.1e-20 71.7 14.3 7.5e-20 70.9 14.3 1.4 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Ammonium_transp PF00909.21 ETO15926.1 - 6e-17 61.4 0.2 6.2e-17 61.4 0.2 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Na_Pi_cotrans PF02690.15 ETO15926.1 - 0.015 15.4 1.0 0.02 15.0 1.0 1.2 1 0 0 1 1 1 0 Na+/Pi-cotransporter SET PF00856.28 ETO15927.1 - 2.3e-09 37.9 0.0 6.1e-08 33.2 0.0 2.1 1 1 0 1 1 1 1 SET domain DUF3657 PF12394.8 ETO15928.1 - 1.3e-08 35.2 1.4 7e-08 32.9 1.0 2.5 2 0 0 2 2 2 1 Protein FAM135 CBM_21 PF03370.13 ETO15928.1 - 0.011 15.9 0.2 0.021 15.0 0.2 1.4 1 0 0 1 1 1 0 Carbohydrate/starch-binding module (family 21) DUF5377 PF17347.2 ETO15928.1 - 0.035 14.5 0.4 0.11 12.9 0.4 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5377) Plasmodium_Vir PF05795.11 ETO15929.1 - 0.4 10.0 8.7 0.46 9.8 8.7 1.2 1 0 0 1 1 1 0 Plasmodium vivax Vir protein PepSY_TM PF03929.16 ETO15929.1 - 0.55 9.9 10.6 0.67 9.6 10.6 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Velvet PF11754.8 ETO15929.1 - 0.73 9.7 20.1 1.1 9.1 20.1 1.3 1 0 0 1 1 1 0 Velvet factor Neur_chan_memb PF02932.16 ETO15929.1 - 0.97 9.4 16.8 1.1 9.3 16.8 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM76 PF16046.5 ETO15929.1 - 2 7.7 22.4 2.2 7.6 22.4 1.1 1 0 0 1 1 1 0 FAM76 protein eIF-3_zeta PF05091.12 ETO15929.1 - 2.2 7.2 29.1 2.4 7.0 29.1 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) DUF1676 PF07898.13 ETO15929.1 - 2.4 8.2 10.6 3.2 7.8 10.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Itfg2 PF15907.5 ETO15929.1 - 2.6 7.0 15.1 2.7 7.0 15.1 1.0 1 0 0 1 1 1 0 Integrin-alpha FG-GAP repeat-containing protein 2 ABC2_membrane_2 PF12679.7 ETO15929.1 - 2.6 7.2 8.2 3.2 7.0 8.2 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Tim54 PF11711.8 ETO15929.1 - 3.3 6.4 17.6 3.4 6.3 17.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4746 PF15928.5 ETO15929.1 - 4.8 6.5 13.1 4.8 6.5 13.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) eIF3_subunit PF08597.10 ETO15929.1 - 6.5 6.6 19.2 7.2 6.4 19.2 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit DUF2140 PF09911.9 ETO15929.1 - 6.9 6.2 16.7 8.2 5.9 16.7 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) OATP PF03137.20 ETO15929.1 - 7.2 4.8 10.9 6.5 4.9 10.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Slu7 PF11708.8 ETO15929.1 - 8.3 6.1 22.7 9.2 5.9 22.7 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor DUF3292 PF11696.8 ETO15929.1 - 8.5 4.6 13.6 8.7 4.6 13.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) FliP PF00813.20 ETO15929.1 - 8.6 6.2 10.1 8.4 6.2 10.1 1.3 1 0 0 1 1 1 0 FliP family Ureide_permease PF07168.11 ETO15929.1 - 8.6 5.0 10.0 9.3 4.9 10.0 1.2 1 0 0 1 1 1 0 Ureide permease Rubis-subs-bind PF09273.11 ETO15932.1 - 0.12 13.0 0.0 0.24 12.1 0.0 1.5 1 0 0 1 1 1 0 Rubisco LSMT substrate-binding DUF4472 PF14739.6 ETO15933.1 - 3e-23 82.6 19.9 3e-23 82.6 19.9 8.9 4 1 3 8 8 8 2 Domain of unknown function (DUF4472) Intein_splicing PF14890.6 ETO15933.1 - 0.006 16.5 0.0 0.15 12.0 0.0 3.4 2 2 1 3 3 3 1 Intein splicing domain ZapB PF06005.12 ETO15933.1 - 0.011 16.2 12.2 0.011 16.2 12.2 12.3 5 4 5 10 10 10 0 Cell division protein ZapB HALZ PF02183.18 ETO15933.1 - 0.079 13.2 0.3 0.079 13.2 0.3 11.6 11 3 1 12 12 12 0 Homeobox associated leucine zipper SPOC PF07744.13 ETO15934.1 - 1.6e-05 24.8 0.2 5.5e-05 23.1 0.1 1.9 2 0 0 2 2 2 1 SPOC domain DUF4834 PF16118.5 ETO15934.1 - 0.00033 21.6 3.8 1 10.4 0.0 4.0 4 0 0 4 4 4 2 Domain of unknown function (DUF4834) RAP1 PF07218.11 ETO15934.1 - 0.0006 18.2 12.2 0.001 17.5 12.2 1.3 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) Presenilin PF01080.17 ETO15934.1 - 0.00064 18.6 0.9 0.00064 18.6 0.9 2.9 3 0 0 3 3 3 1 Presenilin Phage_Gp23 PF10669.9 ETO15934.1 - 0.0027 18.0 0.8 0.0027 18.0 0.8 2.5 3 0 0 3 3 2 1 Protein gp23 (Bacteriophage A118) Velvet PF11754.8 ETO15934.1 - 0.018 15.0 6.9 0.022 14.7 0.9 2.5 2 0 0 2 2 2 0 Velvet factor BatD PF13584.6 ETO15934.1 - 0.055 12.3 0.9 0.12 11.2 0.8 1.6 1 1 0 1 1 1 0 Oxygen tolerance Nha1_C PF08619.10 ETO15934.1 - 0.12 11.5 13.0 0.3 10.2 7.4 2.4 2 1 0 2 2 2 0 Alkali metal cation/H+ antiporter Nha1 C terminus Tudor_RapA PF18337.1 ETO15934.1 - 0.14 12.4 0.4 5.8 7.2 0.4 2.6 1 1 0 1 1 1 0 RapA N-terminal Tudor like domain AAA_31 PF13614.6 ETO15934.1 - 0.53 10.2 2.8 1.1 9.2 0.9 2.5 3 0 0 3 3 3 0 AAA domain Macoilin PF09726.9 ETO15934.1 - 2 6.9 22.6 0.006 15.2 11.0 2.4 2 0 0 2 2 2 0 Macoilin family Herpes_capsid PF06112.11 ETO15934.1 - 4.5 7.3 24.5 11 6.1 24.5 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein FAM176 PF14851.6 ETO15934.1 - 9 6.0 7.1 1.4 8.6 0.0 2.7 3 0 0 3 3 3 0 FAM176 family WD40 PF00400.32 ETO15935.1 - 2e-31 107.5 24.0 4e-07 30.6 0.2 7.6 5 3 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15935.1 - 3.5e-12 46.5 0.2 0.028 14.7 0.0 5.1 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO15935.1 - 5.4e-08 31.9 1.0 0.058 12.0 0.1 3.7 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO15935.1 - 2.4e-07 30.4 6.2 0.0045 16.4 0.1 3.7 3 1 1 4 4 4 2 WD40-like domain PQQ_3 PF13570.6 ETO15935.1 - 0.0013 19.1 0.1 8.6 7.0 0.0 4.3 4 1 0 4 4 4 1 PQQ-like domain ORF6N PF10543.9 ETO15935.1 - 0.37 11.0 3.5 1.2 9.4 3.5 1.8 1 0 0 1 1 1 0 ORF6N domain MCPsignal PF00015.21 ETO15936.1 - 0.0034 17.2 0.1 0.0034 17.2 0.1 2.3 2 1 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain UPF0184 PF03670.13 ETO15936.1 - 0.021 15.2 1.2 0.021 15.2 1.2 2.6 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) PMC2NT PF08066.12 ETO15936.1 - 0.028 15.1 3.4 0.033 14.9 0.3 2.3 2 0 0 2 2 2 0 PMC2NT (NUC016) domain DUF948 PF06103.11 ETO15936.1 - 0.059 13.6 4.7 0.091 13.0 0.1 2.6 2 2 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FlaC_arch PF05377.11 ETO15936.1 - 0.061 13.7 3.1 0.061 13.7 3.1 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ETO15936.1 - 0.095 12.7 0.2 0.095 12.7 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) Glyco_hydro_1 PF00232.18 ETO15936.1 - 0.15 10.4 2.6 0.26 9.6 2.6 1.4 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 DASH_Dam1 PF08653.10 ETO15936.1 - 0.27 11.0 3.3 0.64 9.9 0.2 2.8 2 1 1 3 3 3 0 DASH complex subunit Dam1 COG2 PF06148.11 ETO15936.1 - 0.3 11.2 13.5 0.15 12.2 1.0 3.3 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 TraF PF13728.6 ETO15936.1 - 1.3 8.8 8.2 1.8 8.3 8.2 1.2 1 0 0 1 1 1 0 F plasmid transfer operon protein PEX11 PF05648.14 ETO15936.1 - 1.5 8.2 8.8 0.68 9.3 4.4 2.0 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) SNARE PF05739.19 ETO15936.1 - 2.8 8.0 7.5 3.3 7.8 0.3 2.8 3 0 0 3 3 3 0 SNARE domain Spore_II_R PF09551.10 ETO15936.1 - 3.7 8.0 9.4 4.1 7.9 3.0 2.2 2 0 0 2 2 2 0 Stage II sporulation protein R (spore_II_R) EndIII_4Fe-2S PF10576.9 ETO15937.1 - 0.73 10.3 3.0 1.4 9.3 3.0 1.5 1 0 0 1 1 1 0 Iron-sulfur binding domain of endonuclease III Proteasome PF00227.26 ETO15938.1 - 1.6e-05 24.5 0.1 1.6e-05 24.5 0.1 1.5 2 0 0 2 2 2 1 Proteasome subunit Med26 PF08711.11 ETO15938.1 - 0.023 14.7 0.6 0.045 13.8 0.6 1.5 1 0 0 1 1 1 0 TFIIS helical bundle-like domain Rio2_N PF09202.11 ETO15938.1 - 0.089 13.0 0.2 0.12 12.6 0.2 1.2 1 0 0 1 1 1 0 Rio2, N-terminal DUF5321 PF17254.2 ETO15938.1 - 0.44 10.0 8.2 0.47 9.9 8.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5321) GTP_CH_N PF12471.8 ETO15939.1 - 0.063 13.0 0.0 0.1 12.4 0.0 1.5 1 1 0 1 1 1 0 GTP cyclohydrolase N terminal SPRY PF00622.28 ETO15940.1 - 0.00091 19.3 0.1 0.0017 18.5 0.1 1.5 1 0 0 1 1 1 1 SPRY domain AAA PF00004.29 ETO15941.1 - 8.2e-09 36.0 0.0 1.8e-08 34.9 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Glyco_transf_49 PF13896.6 ETO15941.1 - 0.0037 16.7 0.4 0.006 16.0 0.3 1.4 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan DUF1189 PF06691.11 ETO15942.1 - 0.2 11.2 2.2 0.28 10.7 2.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Pox_Ag35 PF03286.14 ETO15942.1 - 0.25 11.1 5.7 0.048 13.5 1.3 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Orf78 PF06024.12 ETO15942.1 - 9.1 6.7 6.8 7.7 6.9 4.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) WBP-1 PF11669.8 ETO15945.1 - 0.0087 16.7 3.1 0.0087 16.7 3.1 4.8 3 2 2 5 5 4 2 WW domain-binding protein 1 TMEM51 PF15345.6 ETO15945.1 - 0.024 14.5 1.0 0.44 10.3 1.9 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 DUF2755 PF10954.8 ETO15945.1 - 0.024 14.6 0.0 0.19 11.7 0.0 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2755) Cadherin_C_2 PF16492.5 ETO15945.1 - 0.054 14.3 19.6 0.092 13.5 0.1 3.9 3 1 1 4 4 4 0 Cadherin cytoplasmic C-terminal Ctr PF04145.15 ETO15945.1 - 0.12 13.0 3.8 1.7 9.3 0.3 3.1 2 1 0 2 2 2 0 Ctr copper transporter family TFIIA PF03153.13 ETO15945.1 - 0.19 11.7 10.1 0.063 13.3 7.0 1.8 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 ETO15945.1 - 0.24 11.2 2.8 0.22 11.3 0.1 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FAM176 PF14851.6 ETO15945.1 - 0.32 10.6 5.8 2 8.1 0.8 3.5 3 0 0 3 3 3 0 FAM176 family DUF2946 PF11162.8 ETO15945.1 - 0.37 11.5 4.1 0.65 10.7 2.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2946) DUF4834 PF16118.5 ETO15945.1 - 4 8.5 16.8 0.17 12.8 0.7 4.9 6 0 0 6 6 6 0 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 ETO15945.1 - 4.5 8.2 14.4 4.6 8.2 0.1 4.9 6 0 0 6 6 6 0 Ephrin type-A receptor 2 transmembrane domain MLANA PF14991.6 ETO15945.1 - 8.1 6.8 9.8 11 6.3 0.0 3.8 4 1 1 5 5 4 0 Protein melan-A Utp14 PF04615.13 ETO15946.1 - 0.00017 20.4 41.2 0.00019 20.2 41.2 1.1 1 0 0 1 1 1 1 Utp14 protein PHD PF00628.29 ETO15946.1 - 0.0059 16.5 3.1 0.023 14.6 3.1 2.1 1 0 0 1 1 1 1 PHD-finger GREB1 PF15782.5 ETO15946.1 - 4.3 4.3 40.3 5.7 3.9 40.3 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_M41 PF01434.18 ETO15947.1 - 4e-61 206.2 0.0 4e-61 206.2 0.0 1.8 2 0 0 2 2 2 1 Peptidase family M41 AAA PF00004.29 ETO15947.1 - 4.8e-42 143.5 0.0 9.2e-42 142.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO15947.1 - 3.6e-11 42.7 0.0 8.2e-11 41.5 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_22 PF13401.6 ETO15947.1 - 0.00026 21.3 0.0 0.038 14.3 0.0 2.9 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO15947.1 - 0.00071 19.6 0.0 0.0025 17.8 0.0 2.0 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO15947.1 - 0.00078 19.9 0.2 0.021 15.2 0.1 2.6 1 1 0 2 2 2 1 AAA ATPase domain AAA_33 PF13671.6 ETO15947.1 - 0.015 15.5 0.1 0.041 14.0 0.0 1.8 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 ETO15947.1 - 0.016 15.0 0.0 0.037 13.8 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain IstB_IS21 PF01695.17 ETO15947.1 - 0.032 14.0 0.0 0.076 12.7 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein TIP49 PF06068.13 ETO15947.1 - 0.039 13.2 0.0 0.07 12.3 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 ETO15947.1 - 0.055 12.9 0.2 0.13 11.6 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ETO15947.1 - 0.059 13.9 0.1 0.21 12.1 0.0 2.0 2 0 0 2 2 2 0 AAA domain PrsW-protease PF13367.6 ETO15948.1 - 1.4e-09 37.7 5.5 2e-09 37.2 5.5 1.2 1 0 0 1 1 1 1 PrsW family intramembrane metalloprotease DUF2842 PF11003.8 ETO15948.1 - 0.051 13.8 1.5 0.14 12.4 1.5 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2842) SDA1 PF05285.12 ETO15948.1 - 0.44 9.9 57.8 0.73 9.2 57.8 1.3 1 0 0 1 1 1 0 SDA1 Bclt PF15318.6 ETO15949.1 - 0.027 14.3 0.1 0.034 14.0 0.1 1.1 1 0 0 1 1 1 0 Putative Bcl-2 like protein of testis SidE PF12252.8 ETO15949.1 - 0.032 11.8 2.2 0.038 11.5 2.2 1.0 1 0 0 1 1 1 0 Dot/Icm substrate protein Exonuc_VII_L PF02601.15 ETO15949.1 - 0.077 12.6 5.1 0.093 12.3 5.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Seryl_tRNA_N PF02403.22 ETO15949.1 - 0.18 12.1 5.5 0.16 12.2 4.1 1.7 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain FlxA PF14282.6 ETO15949.1 - 0.26 11.3 4.3 6.7 6.8 0.1 2.7 1 1 1 2 2 2 0 FlxA-like protein DUF16 PF01519.16 ETO15949.1 - 0.6 10.6 3.9 1.7 9.2 2.6 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 CENP-F_leu_zip PF10473.9 ETO15949.1 - 0.63 10.1 11.2 2.7 8.0 2.0 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CorA PF01544.18 ETO15949.1 - 2 7.6 8.4 0.18 11.1 0.8 2.3 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein FKBP_C PF00254.28 ETO15950.1 - 7.4e-13 48.6 0.0 1.7e-12 47.5 0.0 1.7 1 1 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase JAB PF01398.21 ETO15951.1 - 1.8e-18 66.6 1.3 2.6e-18 66.1 0.2 1.8 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease USP8_dimer PF08969.11 ETO15951.1 - 1.3e-07 31.8 2.7 2.6e-07 30.8 2.7 1.5 1 0 0 1 1 1 1 USP8 dimerisation domain Prok-JAB PF14464.6 ETO15951.1 - 0.00011 22.0 0.0 0.00018 21.2 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain BTHB PF18410.1 ETO15951.1 - 0.0037 17.1 1.2 0.015 15.1 1.2 2.1 1 0 0 1 1 1 1 Basic tilted helix bundle domain Sec16 PF12932.7 ETO15952.1 - 9.5 6.8 8.2 56 4.4 8.2 2.4 1 1 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region WD40 PF00400.32 ETO15953.1 - 8.6e-36 121.3 3.2 1.6e-11 44.6 0.3 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15953.1 - 1.3e-09 38.3 1.2 0.0031 17.8 0.0 3.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15953.1 - 5.7e-06 25.5 0.0 0.5 9.3 0.1 3.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO15953.1 - 4.9e-05 22.2 0.2 0.02 13.5 0.0 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO15953.1 - 0.0019 18.1 0.5 1.4 8.9 0.1 2.6 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO15953.1 - 0.011 15.1 0.0 0.93 8.8 0.0 2.3 2 0 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 ETO15953.1 - 0.021 13.4 0.0 0.039 12.5 0.0 1.4 1 1 0 1 1 1 0 Cytochrome D1 heme domain WD40 PF00400.32 ETO15954.1 - 4e-71 233.2 25.6 3.6e-11 43.4 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15954.1 - 3.2e-21 75.4 2.0 0.056 13.7 0.1 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15954.1 - 8.9e-13 47.9 0.3 0.2 10.6 0.0 6.3 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO15954.1 - 6.4e-11 42.1 0.3 0.0081 15.5 0.0 3.8 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO15954.1 - 7.9e-10 38.0 4.2 0.092 11.4 0.1 5.3 3 2 2 5 5 5 5 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO15954.1 - 4.6e-09 36.4 2.1 0.00028 20.8 0.0 3.6 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Str_synth PF03088.16 ETO15954.1 - 1.2e-05 25.4 0.9 6.6 6.9 0.0 5.2 3 2 1 5 5 5 1 Strictosidine synthase DUF5570 PF17731.1 ETO15954.1 - 2e-05 24.7 3.2 8 6.6 0.0 5.7 1 1 5 6 6 6 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO15954.1 - 0.00011 20.9 0.4 0.18 10.3 0.0 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain NHL PF01436.21 ETO15954.1 - 0.002 18.1 0.8 17 5.7 0.0 4.6 4 0 0 4 4 4 0 NHL repeat PD40 PF07676.12 ETO15954.1 - 0.0047 16.8 10.7 6.3 6.9 0.4 5.8 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat dCache_1 PF02743.18 ETO15954.1 - 0.013 15.3 0.2 2 8.2 0.1 2.7 2 1 1 3 3 3 0 Cache domain Nucleoporin_N PF08801.11 ETO15954.1 - 0.02 13.6 8.1 1.3 7.6 1.3 4.8 1 1 1 3 3 3 0 Nup133 N terminal like PA14 PF07691.12 ETO15954.1 - 0.034 13.9 0.0 0.089 12.6 0.0 1.7 1 0 0 1 1 1 0 PA14 domain Proteasome_A_N PF10584.9 ETO15954.1 - 3.4 7.4 4.3 68 3.3 0.0 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PHB_acc PF05233.13 ETO15955.1 - 0.0035 17.3 2.8 0.0054 16.7 0.5 2.4 2 0 0 2 2 2 1 PHB accumulation regulatory domain SapB_1 PF05184.15 ETO15955.1 - 0.009 16.0 3.1 0.48 10.5 0.2 2.6 2 0 0 2 2 2 2 Saposin-like type B, region 1 DUF3456 PF11938.8 ETO15955.1 - 0.077 13.5 10.7 0.15 12.6 6.9 3.0 1 1 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP CDC45 PF02724.14 ETO15956.1 - 0.00031 19.2 35.1 0.00041 18.8 35.1 1.2 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO15956.1 - 0.0019 16.5 52.0 0.0021 16.4 52.0 1.0 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO15956.1 - 0.0094 15.4 50.8 0.011 15.1 50.8 1.1 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 ETO15956.1 - 3.4 6.9 49.2 4 6.7 49.2 1.1 1 0 0 1 1 1 0 BUD22 Mpp10 PF04006.12 ETO15956.1 - 3.6 5.9 45.4 5.4 5.3 45.4 1.3 1 0 0 1 1 1 0 Mpp10 protein Hid1 PF12722.7 ETO15956.1 - 3.6 5.6 14.4 4.5 5.3 14.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Viral_Beta_CD PF04530.12 ETO15957.1 - 0.1 12.9 0.0 0.17 12.2 0.0 1.3 1 0 0 1 1 1 0 Viral Beta C/D like family Annexin PF00191.20 ETO15959.1 - 0.00034 20.6 0.1 0.0091 16.1 0.0 2.2 2 0 0 2 2 2 2 Annexin Annexin PF00191.20 ETO15960.1 - 7.2e-25 86.8 5.5 2.5e-10 40.3 0.2 4.9 4 1 0 4 4 4 4 Annexin DUF4172 PF13776.6 ETO15960.1 - 0.086 13.2 0.5 0.35 11.2 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4172) Annexin PF00191.20 ETO15961.1 - 0.0023 18.0 0.1 0.0043 17.1 0.1 1.5 1 0 0 1 1 1 1 Annexin ATP-synt_E PF05680.12 ETO15962.1 - 0.066 13.6 4.4 0.097 13.0 4.4 1.3 1 0 0 1 1 1 0 ATP synthase E chain DCA16 PF15349.6 ETO15962.1 - 0.092 12.3 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 Protocadherin PF08374.11 ETO15962.1 - 0.17 11.8 1.9 0.19 11.7 1.9 1.1 1 0 0 1 1 1 0 Protocadherin PAD_N PF08526.10 ETO15962.1 - 0.29 11.5 1.5 0.37 11.2 0.6 1.5 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) N-terminal domain DUF4519 PF15012.6 ETO15962.1 - 4.5 7.5 8.8 8.8 6.6 8.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4519) Synaptobrevin PF00957.21 ETO15963.1 - 0.035 13.9 1.0 0.087 12.6 1.0 1.6 1 0 0 1 1 1 0 Synaptobrevin VPS13_mid_rpt PF16910.5 ETO15964.1 - 1.1e-06 28.3 9.7 0.011 15.2 0.0 4.1 2 1 0 2 2 2 2 Repeating coiled region of VPS13 NusG_II PF07009.11 ETO15964.1 - 0.12 12.6 0.1 0.39 10.9 0.1 1.9 2 0 0 2 2 2 0 NusG domain II MADF_DNA_bdg PF10545.9 ETO15964.1 - 0.56 10.6 2.7 29 5.1 0.0 3.3 3 0 0 3 3 3 0 Alcohol dehydrogenase transcription factor Myb/SANT-like LPP20 PF02169.16 ETO15964.1 - 1.6 9.1 10.7 1.6 9.1 2.8 2.8 2 0 0 2 2 2 0 LPP20 lipoprotein CARM1 PF11531.8 ETO15965.1 - 0.03 14.5 0.5 0.09 13.0 0.5 1.8 1 0 0 1 1 1 0 Coactivator-associated arginine methyltransferase 1 N terminal Fer4_7 PF12838.7 ETO15965.1 - 0.66 10.6 4.1 0.41 11.3 0.7 2.3 2 0 0 2 2 2 0 4Fe-4S dicluster domain EGL-1 PF11430.8 ETO15966.1 - 0.17 11.7 0.4 0.49 10.3 0.4 1.8 1 0 0 1 1 1 0 Programmed cell death activator EGL-1 DUF4600 PF15372.6 ETO15967.1 - 0.0079 16.6 5.4 0.014 15.8 5.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4600) DHHC PF01529.20 ETO15967.1 - 0.026 14.6 0.4 0.026 14.6 0.4 1.7 2 0 0 2 2 2 0 DHHC palmitoyltransferase DUF148 PF02520.17 ETO15967.1 - 0.032 14.3 5.5 0.062 13.4 5.5 1.4 1 0 0 1 1 1 0 Domain of unknown function DUF148 WD40 PF00400.32 ETO15968.1 - 2.5e-89 290.8 36.7 9.9e-10 38.9 0.3 14.6 14 0 0 14 14 14 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO15968.1 - 4.9e-27 94.1 13.7 0.0049 17.1 0.0 9.4 3 3 5 9 9 9 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO15968.1 - 2.3e-15 56.4 6.3 0.15 11.0 0.0 9.6 1 1 9 11 11 11 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO15968.1 - 2.6e-09 37.2 0.0 5.3e-09 36.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain eIF2A PF08662.11 ETO15968.1 - 1.2e-07 31.8 2.1 0.051 13.5 0.1 5.3 1 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Pentapeptide PF00805.22 ETO15968.1 - 2.3e-07 30.3 1.6 4.6e-07 29.4 1.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO15968.1 - 1.5e-06 28.3 0.5 0.00023 21.3 0.1 2.9 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO15968.1 - 2.2e-06 26.5 3.0 0.38 9.2 0.0 5.1 3 1 3 6 6 6 2 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO15968.1 - 9.7e-05 22.4 0.1 0.00021 21.4 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO15968.1 - 0.00023 21.0 10.8 4.3 7.4 0.1 7.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat DUF1258 PF06869.12 ETO15968.1 - 0.0037 16.8 0.8 4.8 6.6 0.0 4.1 2 2 3 5 5 5 1 Protein of unknown function (DUF1258) AAA_22 PF13401.6 ETO15968.1 - 0.0047 17.2 0.0 0.024 14.9 0.0 2.3 1 1 0 1 1 1 1 AAA domain Mid2 PF04478.12 ETO15968.1 - 0.0053 16.6 9.0 3 7.7 0.1 6.2 6 1 0 6 6 6 1 Mid2 like cell wall stress sensor HARP PF07443.13 ETO15968.1 - 0.0067 16.0 0.1 5.9 6.6 0.0 5.2 6 0 0 6 6 6 1 HepA-related protein (HARP) AAA PF00004.29 ETO15968.1 - 0.018 15.4 0.0 0.51 10.8 0.0 2.8 3 0 0 3 3 2 0 ATPase family associated with various cellular activities (AAA) ATP_bind_2 PF03668.15 ETO15968.1 - 0.055 12.8 0.0 0.1 11.8 0.0 1.4 1 0 0 1 1 1 0 P-loop ATPase protein family Str_synth PF03088.16 ETO15968.1 - 0.087 13.0 0.0 36 4.6 0.0 4.2 4 0 0 4 4 3 0 Strictosidine synthase AAA_16 PF13191.6 ETO15968.1 - 0.11 12.9 0.0 0.62 10.4 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 ETO15968.1 - 0.14 12.6 0.0 0.14 12.6 0.0 4.4 4 1 1 5 5 5 0 RNA helicase ABC_tran PF00005.27 ETO15968.1 - 0.44 11.0 2.5 2.5 8.6 0.0 3.2 3 0 0 3 3 2 0 ABC transporter DUF4048 PF13257.6 ETO15968.1 - 2.8 7.7 7.7 6.1 6.6 7.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4048) Arylesterase PF01731.20 ETO15969.1 - 2.3 8.5 5.7 56 4.0 0.1 3.8 4 0 0 4 4 4 0 Arylesterase Vps51 PF08700.11 ETO15970.1 - 1.6e-08 34.5 2.3 3.1e-08 33.6 2.3 1.4 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ETO15970.1 - 2.8e-06 27.5 0.3 4.3e-06 26.8 0.3 1.3 1 0 0 1 1 1 1 COG (conserved oligomeric Golgi) complex component, COG2 GCIP PF13324.6 ETO15970.1 - 0.0061 16.2 3.9 0.0095 15.6 3.9 1.3 1 0 0 1 1 1 1 Grap2 and cyclin-D-interacting DUF4611 PF15387.6 ETO15970.1 - 0.012 15.9 3.3 0.036 14.3 3.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 ETO15970.1 - 0.27 10.5 7.7 0.44 9.8 7.7 1.4 1 0 0 1 1 1 0 NOA36 protein ALMT PF11744.8 ETO15970.1 - 0.28 9.9 7.2 0.36 9.6 7.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter V_ATPase_I PF01496.19 ETO15970.1 - 0.33 8.8 4.8 0.39 8.6 4.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Glypican PF01153.19 ETO15970.1 - 0.98 8.2 7.8 1.3 7.7 7.8 1.2 1 0 0 1 1 1 0 Glypican GREB1 PF15782.5 ETO15970.1 - 0.98 6.5 10.0 1.2 6.2 10.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 ETO15970.1 - 1.6 7.2 13.2 1.9 6.9 13.2 1.2 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO15971.1 - 0.58 8.5 20.3 0.77 8.0 20.3 1.1 1 0 0 1 1 1 0 Menin eIF_4EBP PF05456.11 ETO15971.1 - 2 8.4 9.0 0.96 9.4 4.6 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) SLC12 PF03522.15 ETO15971.1 - 4.8 6.1 12.9 5.5 5.9 12.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SOG2 PF10428.9 ETO15971.1 - 5.4 6.1 16.4 5.9 6.0 16.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2615 PF11027.8 ETO15972.1 - 0.024 14.8 0.2 0.15 12.2 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) SNF2_N PF00176.23 ETO15973.1 - 1.2e-34 119.6 0.3 1.6e-34 119.2 0.3 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO15973.1 - 7.4e-07 29.3 0.0 5e-06 26.6 0.0 2.1 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ETO15973.1 - 0.0012 18.6 0.0 0.0019 17.9 0.0 1.3 1 0 0 1 1 1 1 SWI2/SNF2 ATPase DUF2075 PF09848.9 ETO15973.1 - 0.05 12.8 0.0 0.1 11.8 0.0 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Helicase_C PF00271.31 ETO15974.1 - 2.2e-16 60.2 0.0 8.5e-16 58.3 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Paf1 PF03985.13 ETO15975.1 - 1.8e-14 53.6 15.7 1.4e-13 50.7 15.7 2.1 1 1 0 1 1 1 1 Paf1 DUF1706 PF08020.11 ETO15975.1 - 0.021 14.7 0.4 0.021 14.7 0.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1706) DapB_C PF05173.14 ETO15975.1 - 5.1 7.2 5.6 13 5.8 0.7 2.9 1 1 0 2 2 2 0 Dihydrodipicolinate reductase, C-terminus EF-hand_1 PF00036.32 ETO15977.1 - 2.5e-33 111.1 19.8 4.4e-09 35.2 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO15977.1 - 2.5e-31 107.9 12.7 3.6e-16 59.4 1.5 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO15977.1 - 4.1e-27 91.7 14.6 1.7e-09 36.8 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ETO15977.1 - 1.8e-25 88.5 17.3 3.2e-13 49.3 1.5 4.2 1 1 3 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO15977.1 - 3.3e-16 58.0 17.6 7.9e-06 25.1 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 ETO15977.1 - 2.6e-12 46.9 1.5 4.4e-06 26.9 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETO15977.1 - 1.2e-06 28.4 9.6 0.059 13.3 0.5 3.3 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO15977.1 - 1.6e-05 25.2 2.3 0.0091 16.3 0.1 2.1 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region SurA_N_3 PF13624.6 ETO15977.1 - 0.00011 22.0 3.4 0.014 15.2 0.9 2.2 2 0 0 2 2 2 2 SurA N-terminal domain Dockerin_1 PF00404.18 ETO15977.1 - 0.0035 17.5 1.8 1 9.6 0.1 2.6 2 0 0 2 2 2 1 Dockerin type I domain DUF853 PF05872.12 ETO15977.1 - 0.0038 15.9 0.3 0.28 9.7 0.1 2.1 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF853) EFhand_Ca_insen PF08726.10 ETO15977.1 - 0.011 15.7 1.9 0.079 13.1 0.2 2.6 2 1 0 2 2 2 0 Ca2+ insensitive EF hand SurA_N_2 PF13623.6 ETO15977.1 - 0.014 15.3 5.2 0.47 10.3 0.7 2.5 1 1 1 2 2 2 0 SurA N-terminal domain Mu-like_Pro PF10123.9 ETO15977.1 - 0.028 14.0 0.2 0.042 13.4 0.2 1.3 1 0 0 1 1 1 0 Mu-like prophage I protein EF-hand_14 PF17959.1 ETO15977.1 - 0.032 14.6 3.3 5.4 7.4 0.1 2.6 1 1 1 2 2 2 0 EF-hand domain DUF5580 PF17743.1 ETO15977.1 - 0.035 12.7 0.0 0.053 12.1 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5580) Caleosin PF05042.13 ETO15977.1 - 0.045 13.7 4.0 12 5.7 0.0 3.8 1 1 2 3 3 3 0 Caleosin related protein SUB1_ProdP9 PF18213.1 ETO15977.1 - 0.066 13.1 3.3 0.079 12.8 0.2 2.2 2 0 0 2 2 2 0 SUB1 protease Prodomain ProdP9 LETM1 PF07766.13 ETO15977.1 - 0.069 12.5 4.1 0.085 12.2 1.2 2.3 1 1 2 3 3 3 0 LETM1-like protein DUF1296 PF06972.11 ETO15977.1 - 0.082 13.1 1.0 1.8 8.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1296) DUF4601 PF15373.6 ETO15977.1 - 0.085 11.8 0.1 0.23 10.4 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4601) ParD_antitoxin PF03693.14 ETO15977.1 - 0.18 12.2 1.5 0.31 11.5 0.2 2.0 2 1 0 2 2 2 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH DUF4834 PF16118.5 ETO15977.1 - 0.25 12.3 3.2 1.9 9.5 0.1 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Leucyl-specific PF14795.6 ETO15977.1 - 0.44 10.6 2.6 14 5.8 0.0 3.0 3 0 0 3 3 3 0 Leucine-tRNA synthetase-specific domain FlgD PF03963.14 ETO15977.1 - 0.96 9.8 7.3 1.1 9.6 5.0 2.2 2 1 0 2 2 2 0 Flagellar hook capping protein - N-terminal region Otopetrin PF03189.13 ETO15978.1 - 0.042 12.7 1.5 0.053 12.3 1.5 1.3 1 0 0 1 1 1 0 Otopetrin Spc7 PF08317.11 ETO15978.1 - 0.68 8.8 29.2 1.2 7.9 29.2 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein FAM76 PF16046.5 ETO15978.1 - 3.3 7.0 28.2 2.4 7.4 21.7 2.1 2 0 0 2 2 2 0 FAM76 protein DUF3552 PF12072.8 ETO15978.1 - 5.5 6.3 43.1 0.35 10.3 34.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) GAS PF13851.6 ETO15978.1 - 7.5 5.8 35.6 0.23 10.8 1.0 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DnaJ_C PF01556.18 ETO15979.1 - 2.9e-36 124.8 0.1 4.6e-36 124.1 0.1 1.3 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ PF00226.31 ETO15979.1 - 5.7e-16 58.4 7.1 3.7e-12 46.2 0.1 2.8 3 0 0 3 3 3 2 DnaJ domain DnaJ_CXXCXGXG PF00684.19 ETO15979.1 - 4.1e-05 23.8 17.2 0.00013 22.3 17.2 1.8 1 1 0 1 1 1 1 DnaJ central domain Cytochrome_CBB3 PF13442.6 ETO15979.1 - 0.011 16.1 0.2 0.011 16.1 0.2 2.7 1 1 1 2 2 2 0 Cytochrome C oxidase, cbb3-type, subunit III Anti-TRAP PF15777.5 ETO15979.1 - 4.9 7.2 15.1 1.8 8.6 9.4 2.4 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein Ribosomal_L28e PF01778.17 ETO15980.1 - 0.003 18.3 4.0 0.0094 16.7 4.0 2.0 1 0 0 1 1 1 1 Ribosomal L28e protein family CDC45 PF02724.14 ETO15981.1 - 0.56 8.4 28.6 0.66 8.2 28.6 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 ETO15981.1 - 3 6.5 8.3 3.4 6.4 8.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter LAP1C PF05609.12 ETO15981.1 - 5.4 6.0 16.6 6.1 5.8 16.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DNA_pol_phi PF04931.13 ETO15981.1 - 8.2 4.4 41.5 9.5 4.2 41.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi RhoGEF PF00621.20 ETO15982.1 - 2.9e-14 53.7 0.9 3.3e-14 53.6 0.9 1.1 1 0 0 1 1 1 1 RhoGEF domain CAP_GLY PF01302.25 ETO15983.1 - 1.3e-27 95.6 9.0 1.2e-20 73.2 1.9 2.2 2 0 0 2 2 2 2 CAP-Gly domain RRM_1 PF00076.22 ETO15985.1 - 7.8e-06 25.6 0.0 0.00022 21.0 0.0 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO15985.1 - 0.00088 19.4 0.1 0.0025 17.9 0.1 1.9 1 1 0 1 1 1 1 RNA recognition motif Phage_Gp23 PF10669.9 ETO15988.1 - 0.003 17.9 1.5 0.0064 16.8 1.5 1.6 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) MAP17 PF15807.5 ETO15988.1 - 0.0032 17.7 0.9 0.0032 17.7 0.9 2.2 2 0 0 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Ctr PF04145.15 ETO15988.1 - 0.03 15.0 0.1 0.03 15.0 0.1 2.5 2 1 1 3 3 3 0 Ctr copper transporter family SID-1_RNA_chan PF13965.6 ETO15988.1 - 0.035 12.5 2.2 0.052 12.0 2.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 ETO15988.1 - 0.052 14.5 10.8 0.18 12.8 0.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF4501 PF14946.6 ETO15988.1 - 0.053 13.6 0.2 0.094 12.8 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) POX PF07526.11 ETO15988.1 - 4.5 7.8 10.0 1.6 9.3 0.8 2.5 2 0 0 2 2 2 0 Associated with HOX CSG2 PF16965.5 ETO15988.1 - 4.7 6.1 8.3 0.79 8.6 3.5 1.8 1 1 1 2 2 2 0 Ceramide synthase regulator GOLD_2 PF13897.6 ETO15988.1 - 7.4 7.1 8.8 0.51 10.8 2.3 2.0 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking HAD_SAK_2 PF18143.1 ETO15989.1 - 6.6e-05 23.3 1.9 0.00033 21.0 0.1 2.5 3 0 0 3 3 3 1 HAD domain in Swiss Army Knife RNA repair proteins Mucin PF01456.17 ETO15989.1 - 0.013 15.5 7.5 0.013 15.5 7.5 2.3 3 0 0 3 3 3 0 Mucin-like glycoprotein TMEM51 PF15345.6 ETO15989.1 - 0.027 14.3 7.9 0.49 10.2 0.1 2.5 2 0 0 2 2 2 0 Transmembrane protein 51 SPX PF03105.19 ETO15989.1 - 0.23 11.3 14.3 0.33 10.8 14.3 1.2 1 0 0 1 1 1 0 SPX domain AIF_C PF14721.6 ETO15989.1 - 0.4 11.0 8.9 2.6 8.4 0.3 2.5 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TFIIA PF03153.13 ETO15989.1 - 0.5 10.3 20.5 0.42 10.6 19.5 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM176 PF14851.6 ETO15989.1 - 0.73 9.5 3.0 10 5.8 0.1 2.4 2 0 0 2 2 2 0 FAM176 family Amino_oxidase PF01593.24 ETO15991.1 - 1.2e-25 90.7 0.0 4.5e-22 79.0 0.0 2.2 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase zf-HC5HC2H PF13771.6 ETO15991.1 - 1.1e-06 28.8 4.9 1.1e-06 28.8 4.9 2.0 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ETO15991.1 - 1.9e-05 24.8 5.0 4.3e-05 23.6 5.0 1.7 1 0 0 1 1 1 1 PHD-zinc-finger like domain XPG_I PF00867.18 ETO15992.1 - 1.7e-29 102.0 0.5 4.1e-29 100.8 0.0 1.9 2 0 0 2 2 2 1 XPG I-region XPG_N PF00752.17 ETO15992.1 - 7.4e-19 68.1 0.0 1.8e-18 66.8 0.0 1.7 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ETO15992.1 - 1.1e-09 38.8 0.0 3e-09 37.3 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold 5_3_exonuc_N PF02739.16 ETO15992.1 - 0.003 17.5 0.0 0.0047 16.8 0.0 1.4 1 0 0 1 1 1 1 5'-3' exonuclease, N-terminal resolvase-like domain HHH_2 PF12826.7 ETO15992.1 - 0.011 15.8 0.0 0.023 14.8 0.0 1.4 1 0 0 1 1 1 0 Helix-hairpin-helix motif HHH_5 PF14520.6 ETO15992.1 - 0.11 13.2 0.0 0.26 11.9 0.0 1.6 1 0 0 1 1 1 0 Helix-hairpin-helix domain Arabino_trans_N PF17689.1 ETO15993.1 - 0.074 13.2 4.9 0.19 11.9 3.3 2.0 1 1 1 2 2 2 0 Arabinosyltransferase concanavalin like domain FeoB_associated PF12669.7 ETO15994.1 - 0.094 13.1 0.1 0.18 12.2 0.1 1.5 1 0 0 1 1 1 0 FeoB-associated Cys-rich membrane protein Frizzled PF01534.17 ETO15996.1 - 0.023 13.7 0.0 0.033 13.3 0.0 1.2 1 0 0 1 1 1 0 Frizzled/Smoothened family membrane region COX16 PF14138.6 ETO15996.1 - 0.075 13.6 2.8 13 6.4 2.6 2.8 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 DUF4798 PF16055.5 ETO15996.1 - 0.23 11.7 5.2 0.75 10.1 5.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) UPF0239 PF06783.11 ETO15996.1 - 5.1 7.4 8.2 1 9.6 0.1 2.9 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) FH2 PF02181.23 ETO15998.1 - 6.4e-23 81.5 6.8 7.6e-23 81.2 6.8 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain RTP1_C2 PF10304.9 ETO15998.1 - 0.074 12.8 0.5 0.19 11.4 0.2 1.9 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 2 AATF-Che1 PF13339.6 ETO15998.1 - 0.11 13.1 3.3 0.16 12.6 2.5 1.9 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor Guanylin PF02058.15 ETO15998.1 - 0.14 12.6 0.1 0.57 10.7 0.0 2.1 2 0 0 2 2 2 0 Guanylin precursor FH2 PF02181.23 ETO15999.1 - 1.9e-18 66.7 0.5 1.9e-18 66.7 0.5 2.5 2 0 0 2 2 2 1 Formin Homology 2 Domain UPF0449 PF15136.6 ETO15999.1 - 0.95 10.0 13.1 0.12 12.8 4.2 3.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Fib_alpha PF08702.10 ETO15999.1 - 1.7 8.8 10.4 6.9 6.8 10.4 2.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Reticulon PF02453.17 ETO16000.1 - 0.036 14.0 0.1 0.058 13.4 0.1 1.3 1 0 0 1 1 1 0 Reticulon ABC_membrane PF00664.23 ETO16000.1 - 0.16 11.6 1.0 0.27 10.9 0.1 1.7 2 0 0 2 2 2 0 ABC transporter transmembrane region Presenilin PF01080.17 ETO16000.1 - 4.5 5.9 8.8 43 2.7 0.0 2.3 2 0 0 2 2 2 0 Presenilin Menin PF05053.13 ETO16000.1 - 9.6 4.4 10.6 17 3.6 10.6 1.4 1 0 0 1 1 1 0 Menin Gemini_mov PF01708.16 ETO16001.1 - 0.16 11.8 0.4 0.37 10.6 0.4 1.6 1 0 0 1 1 1 0 Geminivirus putative movement protein Alba PF01918.21 ETO16002.1 - 3.7e-13 49.1 0.0 9e-13 47.9 0.0 1.7 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 ETO16002.1 - 0.011 15.8 0.3 0.017 15.1 0.3 1.4 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P DUF3567 PF12091.8 ETO16002.1 - 0.042 14.0 0.0 7.8 6.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3567) Cas9_a PF18470.1 ETO16002.1 - 0.079 12.5 0.0 0.82 9.2 0.0 2.0 2 0 0 2 2 2 0 Cas9 alpha-helical lobe domain FANCI_S1-cap PF14674.6 ETO16002.1 - 0.17 12.0 0.1 0.47 10.6 0.1 1.8 1 0 0 1 1 1 0 FANCI solenoid 1 cap WD40 PF00400.32 ETO16003.1 - 8.1e-51 168.9 22.6 9.4e-13 48.4 0.1 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16003.1 - 3e-19 69.1 2.4 5.5e-05 23.4 0.0 5.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16003.1 - 6.2e-13 48.4 0.3 0.0026 16.8 0.0 4.5 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO16003.1 - 2.3e-11 43.6 0.7 9.1e-09 35.1 0.2 2.3 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO16003.1 - 2.4e-09 37.4 0.0 5.9e-06 26.3 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO16003.1 - 1.4e-06 28.1 0.2 14 5.8 0.0 5.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO16003.1 - 4.3e-06 25.7 0.4 0.0081 14.8 0.1 3.1 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF727 PF05303.12 ETO16003.1 - 5e-06 26.5 0.3 9.6 6.3 0.0 4.7 1 1 4 5 5 5 0 Protein of unknown function (DUF727) BBS2_Mid PF14783.6 ETO16003.1 - 3.1e-05 23.9 0.6 0.84 9.7 0.1 4.2 2 1 1 3 3 3 2 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 ETO16003.1 - 0.00014 20.5 0.1 0.0047 15.5 0.0 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain Frtz PF11768.8 ETO16003.1 - 0.00033 19.1 0.1 0.16 10.2 0.0 2.8 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz HARP PF07443.13 ETO16003.1 - 0.00095 18.8 0.1 10 5.8 0.0 4.2 5 0 0 5 5 5 0 HepA-related protein (HARP) Reg_prop PF07494.11 ETO16003.1 - 0.0013 18.7 0.4 2 8.9 0.0 4.2 5 0 0 5 5 4 1 Two component regulator propeller B_lectin PF01453.24 ETO16003.1 - 0.0053 17.3 2.7 5.6 7.6 0.0 3.3 2 1 1 3 3 3 1 D-mannose binding lectin Proteasome_A_N PF10584.9 ETO16003.1 - 0.01 15.5 7.1 7.4 6.3 0.0 5.4 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Nucleoporin_N PF08801.11 ETO16003.1 - 0.027 13.2 7.0 0.78 8.4 5.9 3.4 1 1 1 2 2 2 0 Nup133 N terminal like DUF4123 PF13503.6 ETO16003.1 - 0.062 13.7 0.1 0.24 11.8 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4123) Ret2_MD PF18528.1 ETO16003.1 - 0.077 13.4 0.0 22 5.5 0.0 3.2 2 1 1 3 3 3 0 RNA editing 3' terminal uridylyl transferase 2 middle domain DHFR_2 PF06442.11 ETO16003.1 - 0.15 11.9 0.0 14 5.6 0.0 3.3 4 0 0 4 4 4 0 R67 dihydrofolate reductase PH_TFIIH PF08567.11 ETO16003.1 - 0.17 12.2 2.0 35 4.8 0.0 3.7 3 2 1 4 4 4 0 TFIIH p62 subunit, N-terminal domain Prp19 PF08606.11 ETO16004.1 - 0.1 12.6 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Prp19/Pso4-like RRM_1 PF00076.22 ETO16005.1 - 0.011 15.5 0.2 0.048 13.5 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CCDC-167 PF15188.6 ETO16005.1 - 0.015 15.6 6.1 0.015 15.6 6.1 3.4 2 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 HN PF00423.19 ETO16005.1 - 0.11 11.2 5.9 0.17 10.7 5.9 1.2 1 0 0 1 1 1 0 Haemagglutinin-neuraminidase DUF4407 PF14362.6 ETO16005.1 - 0.12 11.8 15.3 0.21 10.9 15.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1848 PF08902.11 ETO16005.1 - 0.68 9.6 6.8 1.2 8.8 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) Syntaxin-6_N PF09177.11 ETO16005.1 - 1.8 9.2 14.8 0.22 12.1 6.1 2.7 1 1 1 2 2 2 0 Syntaxin 6, N-terminal CorA PF01544.18 ETO16005.1 - 1.8 7.8 8.8 3.5 6.9 8.8 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein LMBR1 PF04791.16 ETO16005.1 - 1.9 7.3 7.4 2.7 6.8 7.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 ETO16005.1 - 2.4 7.6 15.9 0.62 9.6 12.8 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit Fib_alpha PF08702.10 ETO16005.1 - 2.5 8.3 22.3 12 6.0 3.5 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family AAA_23 PF13476.6 ETO16005.1 - 7.3 7.0 28.5 24 5.3 28.4 2.0 1 1 0 1 1 1 0 AAA domain RRM_1 PF00076.22 ETO16006.1 - 9.8e-08 31.7 0.0 2e-07 30.7 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ANAPC4_WD40 PF12894.7 ETO16009.1 - 0.037 14.3 1.5 0.85 10.0 0.0 2.8 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ETO16010.1 - 0.026 13.1 0.0 0.027 13.0 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain DRTGG PF07085.12 ETO16010.1 - 0.07 12.9 0.1 0.11 12.3 0.1 1.3 1 0 0 1 1 1 0 DRTGG domain TFIIF_alpha PF05793.12 ETO16011.1 - 0.011 14.4 29.1 0.011 14.3 29.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Tim54 PF11711.8 ETO16011.1 - 0.094 11.5 18.7 0.15 10.8 18.7 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CDC45 PF02724.14 ETO16011.1 - 0.36 9.1 27.7 0.48 8.6 27.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO16011.1 - 0.79 9.1 35.0 1.3 8.4 35.0 1.3 1 0 0 1 1 1 0 SDA1 TRAP_alpha PF03896.16 ETO16011.1 - 1.2 8.3 13.1 1.7 7.7 13.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Trypan_PARP PF05887.11 ETO16011.1 - 1.8 8.5 16.8 2.8 7.9 16.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DDRGK PF09756.9 ETO16011.1 - 3.4 7.2 36.9 4.9 6.7 36.9 1.2 1 0 0 1 1 1 0 DDRGK domain PTPRCAP PF15713.5 ETO16011.1 - 3.5 7.9 24.4 1.4 9.2 21.8 1.8 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Roughex PF06020.11 ETO16011.1 - 3.7 6.5 14.9 5.3 6.0 14.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Mitofilin PF09731.9 ETO16011.1 - 3.9 6.2 29.2 4.3 6.0 29.2 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Borrelia_P83 PF05262.11 ETO16011.1 - 4.7 5.6 21.9 4.7 5.6 21.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein HSP90 PF00183.18 ETO16011.1 - 6.4 5.6 25.5 8.4 5.2 25.5 1.1 1 0 0 1 1 1 0 Hsp90 protein Otopetrin PF03189.13 ETO16011.1 - 6.6 5.4 9.4 7.4 5.3 9.4 1.4 1 0 0 1 1 1 0 Otopetrin Paramyxo_ncap PF00973.19 ETO16011.1 - 7.2 5.4 13.9 7.6 5.3 13.9 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Membralin PF09746.9 ETO16011.1 - 7.7 5.4 13.5 8.2 5.3 13.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF3987 PF13148.6 ETO16011.1 - 9.2 5.2 11.3 12 4.8 11.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Kelch_1 PF01344.25 ETO16012.1 - 0.00015 21.2 1.2 0.2 11.3 0.2 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO16012.1 - 0.0012 18.8 0.3 0.029 14.4 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO16012.1 - 0.0024 18.1 7.4 15 6.1 0.0 4.9 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 ETO16012.1 - 0.0084 16.1 0.9 21 5.3 0.0 4.4 5 0 0 5 5 5 2 Kelch motif fn3 PF00041.21 ETO16013.1 - 0.00022 21.5 1.0 0.0014 18.9 0.4 2.1 2 0 0 2 2 2 1 Fibronectin type III domain RGS PF00615.19 ETO16014.1 - 0.023 15.0 0.9 0.056 13.7 0.9 1.6 1 0 0 1 1 1 0 Regulator of G protein signaling domain Mt_ATP-synt_B PF05405.14 ETO16015.1 - 0.025 14.2 0.6 0.025 14.2 0.6 1.6 2 0 0 2 2 2 0 Mitochondrial ATP synthase B chain precursor (ATP-synt_B) MscL PF01741.18 ETO16017.1 - 0.41 11.0 2.2 1.5 9.2 2.2 2.0 1 1 0 1 1 1 0 Large-conductance mechanosensitive channel, MscL WD40 PF00400.32 ETO16018.1 - 2.1e-95 310.0 46.3 1.1e-08 35.6 0.2 15.8 15 1 0 15 15 15 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16018.1 - 1.3e-29 102.3 16.7 0.037 14.3 0.1 12.7 1 1 13 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16018.1 - 1.4e-17 63.7 8.8 0.21 10.5 0.0 10.8 4 1 6 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO16018.1 - 2.6e-11 43.4 22.3 1.5e-07 31.1 4.4 6.0 3 2 3 6 6 6 3 WD40-like domain Pentapeptide PF00805.22 ETO16018.1 - 5.6e-08 32.3 0.7 1.1e-07 31.4 0.7 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO16018.1 - 4.3e-06 26.5 16.2 3 7.9 0.0 9.7 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO16018.1 - 1.5e-05 24.8 0.3 0.73 9.4 0.1 4.3 3 2 1 4 4 4 1 PQQ-like domain DUF5046 PF16465.5 ETO16018.1 - 0.00021 20.8 0.6 0.6 9.5 0.1 4.3 2 1 3 5 5 5 1 Domain of unknown function (DUF5046) Pentapeptide_4 PF13599.6 ETO16018.1 - 0.00079 19.5 0.4 0.0026 17.9 0.4 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO16018.1 - 0.00081 19.5 0.6 0.002 18.3 0.6 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Me-amine-dh_H PF06433.11 ETO16018.1 - 0.0026 16.7 0.9 0.65 8.8 0.0 3.9 4 0 0 4 4 4 1 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO16018.1 - 0.0054 15.3 9.0 3.4 6.1 0.0 5.2 3 2 3 6 6 6 2 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO16018.1 - 0.033 13.9 2.7 19 5.1 0.0 5.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF5609 PF18429.1 ETO16018.1 - 0.083 12.7 0.1 0.37 10.6 0.1 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5609) Spc29 PF17082.5 ETO16018.1 - 2.2 8.1 5.2 4 7.2 2.4 3.1 2 1 0 2 2 2 0 Spindle Pole Component 29 FAM176 PF14851.6 ETO16020.1 - 0.095 12.4 2.6 0.12 12.0 2.6 1.2 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO16020.1 - 0.14 11.5 5.8 0.16 11.2 5.8 1.2 1 0 0 1 1 1 0 NOA36 protein F-protein PF00469.20 ETO16020.1 - 0.24 11.0 0.0 0.24 11.0 0.0 2.0 1 1 1 2 2 2 0 Negative factor, (F-Protein) or Nef DUF1345 PF07077.11 ETO16022.1 - 0.018 14.8 0.5 0.089 12.5 0.0 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1345) SAYSvFN PF10260.9 ETO16022.1 - 0.048 13.6 0.4 1.8 8.6 0.0 2.7 2 0 0 2 2 2 0 Uncharacterized conserved domain (SAYSvFN) OAD_gamma PF04277.13 ETO16022.1 - 0.51 11.0 1.5 22 5.7 0.3 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Saf_2TM PF18303.1 ETO16022.1 - 1.4 8.5 3.5 0.5 10.0 0.3 2.0 2 1 0 2 2 2 0 SAVED-fused 2TM effector domain PrgI PF12666.7 ETO16022.1 - 1.6 9.5 6.4 2.4 8.9 0.0 3.4 3 1 0 3 3 3 0 PrgI family protein DctQ PF04290.12 ETO16022.1 - 2.9 7.8 6.8 53 3.7 0.1 3.1 2 1 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component DUF5373 PF17343.2 ETO16022.1 - 7.6 6.3 9.4 1.6 8.6 0.6 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5373) DUF1681 PF07933.14 ETO16023.1 - 2.3e-19 69.6 0.0 3.4e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1681) Goodbye PF17109.5 ETO16024.1 - 0.12 12.8 1.0 0.22 12.0 0.3 1.8 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain RFC1 PF08519.12 ETO16024.1 - 0.14 12.3 3.7 0.3 11.2 1.8 2.1 1 1 1 2 2 2 0 Replication factor RFC1 C terminal domain adh_short PF00106.25 ETO16025.1 - 4.5e-05 23.0 0.1 5.9e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO16025.1 - 0.048 13.2 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase WD40 PF00400.32 ETO16026.1 - 2.8e-06 28.0 0.0 4.8e-06 27.2 0.0 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16026.1 - 0.085 13.2 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO16027.1 - 8.4e-21 73.9 11.1 1.7e-08 35.0 0.3 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16027.1 - 4.2e-08 33.4 0.1 0.46 10.8 0.0 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16027.1 - 0.0014 18.0 0.0 0.042 13.2 0.0 2.6 2 1 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETO16027.1 - 0.0089 15.9 0.0 0.26 11.2 0.0 2.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO16027.1 - 0.17 10.8 0.7 16 4.3 0.0 2.8 2 1 1 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO16027.1 - 0.24 10.0 2.6 3.4 6.2 0.1 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 RdRP PF05183.12 ETO16028.1 - 9.4e-21 74.1 0.0 1.2e-20 73.7 0.0 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase ASFV_J13L PF05568.11 ETO16028.1 - 0.025 14.3 3.3 0.037 13.8 3.3 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein ODV-E18 PF10717.9 ETO16028.1 - 0.088 12.7 1.8 0.15 12.0 1.8 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ATP-synt_8 PF00895.20 ETO16028.1 - 9.5 6.8 6.5 19 5.8 6.5 1.5 1 0 0 1 1 1 0 ATP synthase protein 8 YL1 PF05764.13 ETO16029.1 - 0.056 13.6 11.8 0.081 13.0 11.8 1.2 1 0 0 1 1 1 0 YL1 nuclear protein Zip PF02535.22 ETO16029.1 - 0.12 11.6 9.0 15 4.6 9.0 2.2 1 1 0 1 1 1 0 ZIP Zinc transporter LAP1C PF05609.12 ETO16029.1 - 0.27 10.3 9.3 0.34 10.0 9.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF2457 PF10446.9 ETO16029.1 - 0.41 9.7 21.4 0.6 9.2 21.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF810 PF05664.11 ETO16029.1 - 1.1 7.7 3.4 1.7 7.1 3.4 1.2 1 0 0 1 1 1 0 Plant family of unknown function (DUF810) Nop14 PF04147.12 ETO16029.1 - 1.4 7.0 18.8 1.8 6.7 18.8 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO16029.1 - 1.6 7.0 19.0 2.1 6.6 19.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4834 PF16118.5 ETO16029.1 - 1.7 9.6 10.9 1.6e+03 0.1 10.9 2.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) eIF-3c_N PF05470.12 ETO16029.1 - 8.9 4.5 12.5 12 4.1 12.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus Macoilin PF09726.9 ETO16030.1 - 1.2 7.6 25.7 1.6 7.2 25.7 1.1 1 0 0 1 1 1 0 Macoilin family DUF489 PF04356.12 ETO16032.1 - 0.012 15.6 3.6 0.015 15.3 3.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF489) DUF745 PF05335.13 ETO16032.1 - 1.3 8.7 15.0 0.35 10.6 7.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF745) RRM_1 PF00076.22 ETO16034.1 - 0.0075 16.1 0.0 0.018 14.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DNA_pol_phi PF04931.13 ETO16034.1 - 0.56 8.2 23.3 1.3 7.0 23.3 1.5 1 0 0 1 1 1 0 DNA polymerase phi DUF3439 PF11921.8 ETO16034.1 - 1.1 9.3 11.4 0.091 12.7 4.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) FmiP_Thoc5 PF09766.9 ETO16035.1 - 9.1e-06 25.2 8.7 9.1e-06 25.2 8.7 2.2 2 1 0 2 2 2 1 Fms-interacting protein/Thoc5 KASH_CCD PF14662.6 ETO16035.1 - 0.009 15.8 3.7 0.009 15.8 3.7 3.0 2 1 0 2 2 2 1 Coiled-coil region of CCDC155 or KASH Sec34 PF04136.15 ETO16035.1 - 0.01 15.7 5.6 0.01 15.7 5.6 2.5 2 1 0 2 2 2 0 Sec34-like family Cnn_1N PF07989.11 ETO16035.1 - 0.012 15.7 2.5 0.012 15.7 2.5 4.1 3 1 1 4 4 4 0 Centrosomin N-terminal motif 1 DUF1874 PF08960.10 ETO16035.1 - 0.071 13.3 6.8 1.7 8.8 2.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF1874) Fez1 PF06818.15 ETO16035.1 - 0.18 12.2 19.1 0.34 11.3 12.2 2.1 2 0 0 2 2 2 0 Fez1 Allexi_40kDa PF05549.11 ETO16035.1 - 0.18 11.3 13.3 0.12 11.8 2.9 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein Golgin_A5 PF09787.9 ETO16035.1 - 0.34 10.3 28.4 0.1 12.1 20.0 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 Rubis-subs-bind PF09273.11 ETO16035.1 - 0.39 11.4 11.7 0.072 13.8 6.6 2.1 2 0 0 2 2 2 0 Rubisco LSMT substrate-binding DASH_Spc19 PF08287.11 ETO16035.1 - 0.54 10.1 21.5 0.11 12.4 0.9 2.4 2 1 0 2 2 2 0 Spc19 AIF-MLS PF14962.6 ETO16035.1 - 0.92 9.4 6.4 1.7 8.6 6.4 1.4 1 0 0 1 1 1 0 Mitochondria Localisation Sequence Fmp27_WPPW PF10359.9 ETO16035.1 - 1.3 7.8 19.4 1.2 8.0 11.2 2.1 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF3300 PF11737.8 ETO16035.1 - 1.5 8.3 7.1 2.7 7.5 7.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3300) ADIP PF11559.8 ETO16035.1 - 2.7 8.1 27.8 0.82 9.7 4.0 2.9 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 ETO16035.1 - 7.2 5.9 19.7 1 8.7 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 ETO16035.1 - 7.5 6.6 36.0 0.37 10.8 15.4 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein T3SSipB PF16535.5 ETO16035.1 - 7.9 6.9 17.5 1.3 9.5 11.6 2.1 2 0 0 2 2 2 0 Type III cell invasion protein SipB Spc7 PF08317.11 ETO16035.1 - 9.2 5.0 30.0 0.87 8.4 15.5 2.8 2 1 1 3 3 3 0 Spc7 kinetochore protein IMS PF00817.20 ETO16036.1 - 4.5e-17 62.4 0.0 9.5e-17 61.4 0.0 1.5 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ETO16036.1 - 0.00078 20.1 0.0 0.0025 18.5 0.0 1.8 2 0 0 2 2 2 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ETO16036.1 - 0.0047 17.2 0.1 0.012 15.9 0.1 1.7 1 0 0 1 1 1 1 IMS family HHH motif CRAL_TRIO PF00650.20 ETO16036.1 - 0.022 14.5 0.0 0.056 13.2 0.0 1.6 1 0 0 1 1 1 0 CRAL/TRIO domain TEX13 PF15186.6 ETO16037.1 - 0.039 13.6 0.0 0.055 13.1 0.0 1.3 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family DUF4216 PF13952.6 ETO16037.1 - 0.058 13.8 0.2 0.13 12.7 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4216) PAM2 PF07145.15 ETO16037.1 - 1.4 8.7 4.8 1.3 8.8 1.3 2.3 2 0 0 2 2 2 0 Ataxin-2 C-terminal region TMEMspv1-c74-12 PF11044.8 ETO16037.1 - 4.2 7.4 9.2 1.9 8.6 3.3 2.3 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein MGC-24 PF05283.11 ETO16037.1 - 6 7.3 9.0 6.2 7.3 7.6 1.7 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SDA1 PF05285.12 ETO16038.1 - 0.0093 15.4 6.7 0.011 15.2 6.7 1.1 1 0 0 1 1 1 1 SDA1 Arm PF00514.23 ETO16039.1 - 0.046 13.8 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat TMEM135_C_rich PF15982.5 ETO16041.1 - 0.0004 21.0 5.5 0.00062 20.4 0.0 3.0 3 1 1 4 4 4 1 N-terminal cysteine-rich region of Transmembrane protein 135 Cu PF17563.2 ETO16041.1 - 1.6 9.0 3.4 1.4 9.2 0.4 2.1 2 0 0 2 2 2 0 Cupiennin Alginate_lyase PF05426.12 ETO16042.1 - 0.00095 18.8 7.7 0.011 15.3 1.2 2.2 2 0 0 2 2 2 2 Alginate lyase Apis_Csd PF11671.8 ETO16044.1 - 7.8 6.5 8.4 11 6.1 4.1 2.3 2 0 0 2 2 2 0 Complementary sex determiner protein DUF3446 PF11928.8 ETO16045.1 - 0.023 15.0 12.4 0.068 13.5 12.4 1.8 1 0 0 1 1 1 0 Early growth response N-terminal domain Shisa PF13908.6 ETO16045.1 - 0.026 14.8 2.7 0.026 14.8 2.7 2.1 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator Leu_zip PF15294.6 ETO16045.1 - 0.27 10.7 31.9 0.02 14.4 9.0 2.6 2 1 0 2 2 2 0 Leucine zipper GAS PF13851.6 ETO16045.1 - 0.48 9.7 31.5 0.021 14.2 6.2 3.0 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding Spc7 PF08317.11 ETO16045.1 - 0.84 8.5 28.3 0.1 11.5 6.7 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein ECSIT_C PF14784.6 ETO16045.1 - 1 9.7 7.3 0.18 12.1 1.1 2.6 2 1 0 2 2 2 0 C-terminal domain of the ECSIT protein Seryl_tRNA_N PF02403.22 ETO16045.1 - 1.6 9.0 20.4 9.2 6.5 5.3 3.2 3 1 0 3 3 3 0 Seryl-tRNA synthetase N-terminal domain UPF0242 PF06785.11 ETO16045.1 - 1.7 8.7 28.6 0.18 11.9 6.4 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Chorion_2 PF03964.15 ETO16045.1 - 6.5 7.7 15.6 3.7 8.4 11.3 2.3 2 0 0 2 2 2 0 Chorion family 2 SKA2 PF16740.5 ETO16045.1 - 8 6.3 23.3 0.022 14.5 8.7 3.1 2 1 0 2 2 2 0 Spindle and kinetochore-associated protein 2 UPF0160 PF03690.13 ETO16046.1 - 1.7e-58 198.8 0.0 2e-58 198.6 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) UAA PF08449.11 ETO16047.1 - 5.8e-29 101.3 18.8 7.2e-29 100.9 18.8 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO16047.1 - 0.064 13.4 21.0 0.046 13.9 9.6 2.2 2 0 0 2 2 2 0 EamA-like transporter family CYSTM PF12734.7 ETO16047.1 - 2 8.8 8.9 0.38 11.1 0.5 2.4 2 0 0 2 2 2 0 Cysteine-rich TM module stress tolerance U-box PF04564.15 ETO16048.1 - 6.6e-09 35.8 0.0 1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 U-box domain CIDR1_gamma PF18562.1 ETO16048.1 - 0.1 12.7 2.2 0.25 11.5 1.3 2.0 2 0 0 2 2 2 0 Cysteine-Rich Interdomain Region 1 gamma CMD PF02627.20 ETO16049.1 - 4.1e-08 33.2 0.1 7.1e-08 32.4 0.1 1.4 1 0 0 1 1 1 1 Carboxymuconolactone decarboxylase family zf-MIZ PF02891.20 ETO16050.1 - 2.2e-17 62.5 9.3 2.2e-17 62.5 9.3 2.3 2 0 0 2 2 2 1 MIZ/SP-RING zinc finger zf-MYND PF01753.18 ETO16050.1 - 3.1e-08 33.6 10.6 3.1e-08 33.6 10.6 2.1 2 0 0 2 2 2 1 MYND finger zf-Nse PF11789.8 ETO16050.1 - 6.9e-05 22.6 1.7 0.00023 20.9 1.7 2.0 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit DUF3585 PF12130.8 ETO16050.1 - 2.3 8.3 6.7 0.28 11.3 0.8 2.1 2 0 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain WD40 PF00400.32 ETO16051.1 - 1.1e-31 108.4 27.6 2.4e-06 28.1 0.4 8.1 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16051.1 - 5.1e-13 49.1 0.8 0.0046 17.2 0.0 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16051.1 - 1.9e-11 43.3 0.9 0.00093 17.9 0.0 5.2 3 3 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16051.1 - 9.7e-05 21.8 5.4 0.75 9.1 0.1 4.4 2 1 3 5 5 5 3 WD40-like domain DUF4178 PF13785.6 ETO16051.1 - 0.19 11.8 0.9 2.3 8.4 0.1 2.7 2 2 0 2 2 2 0 Domain of unknown function (DUF4178) GTP_EFTU_D2 PF03144.25 ETO16052.1 - 0.00061 20.1 0.0 0.0058 17.0 0.0 2.3 1 1 0 1 1 1 1 Elongation factor Tu domain 2 Zip PF02535.22 ETO16052.1 - 0.018 14.2 0.5 0.03 13.5 0.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter V_ATPase_I PF01496.19 ETO16052.1 - 0.077 10.9 3.9 0.1 10.5 3.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ATAD4 PF15321.6 ETO16052.1 - 1.4 10.3 13.2 0.37 12.1 7.8 2.3 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 TP53IP5 PF15331.6 ETO16053.1 - 3.2 7.8 15.2 5.1 7.2 15.0 1.4 1 1 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 GREB1 PF15782.5 ETO16053.1 - 9.4 3.2 10.3 11 3.0 10.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4533 PF15047.6 ETO16055.1 - 0.044 13.3 0.0 0.069 12.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4533) Cnd1_N PF12922.7 ETO16056.1 - 0.022 14.6 0.1 0.056 13.3 0.1 1.6 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term PUB PF09409.10 ETO16057.1 - 3.4e-07 30.1 0.0 8.5e-07 28.8 0.0 1.7 1 0 0 1 1 1 1 PUB domain Fringe PF02434.16 ETO16059.1 - 7.3e-05 22.3 0.1 0.00016 21.2 0.1 1.5 1 1 0 1 1 1 1 Fringe-like WD40 PF00400.32 ETO16060.1 - 1.8e-18 66.5 13.1 4.8e-05 24.0 2.5 5.5 5 2 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO16060.1 - 1.9e-05 23.5 1.0 0.2 10.2 0.0 3.3 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16060.1 - 7.7e-05 22.9 0.4 0.74 10.2 0.0 4.0 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16060.1 - 0.00033 20.1 3.8 0.2 10.9 0.2 2.5 2 1 0 2 2 2 2 WD40-like domain YqaJ PF09588.10 ETO16063.1 - 0.012 15.8 0.9 3.2 7.9 0.0 2.7 3 0 0 3 3 3 0 YqaJ-like viral recombinase domain DUF5589 PF17672.1 ETO16064.1 - 0.035 14.0 0.1 0.069 13.1 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5589) UPF0020 PF01170.18 ETO16065.1 - 0.083 12.6 0.2 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Putative RNA methylase family UPF0020 PP2C PF00481.21 ETO16067.1 - 1.3e-17 64.3 0.0 1.8e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 ETO16067.1 - 0.032 13.9 0.2 0.048 13.3 0.2 1.3 1 1 0 1 1 1 0 Protein phosphatase 2C PAS_12 PF18095.1 ETO16067.1 - 0.099 12.3 0.1 0.33 10.6 0.1 1.8 2 0 0 2 2 2 0 UPF0242 C-terminal PAS-like domain WD40 PF00400.32 ETO16069.1 - 1e-33 114.8 28.4 1.2e-05 26.0 1.3 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO16069.1 - 1.3e-11 43.9 4.4 0.036 12.7 0.1 5.7 2 2 4 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16069.1 - 5e-09 36.3 1.0 0.21 11.9 0.0 5.7 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Pox_Ag35 PF03286.14 ETO16071.1 - 0.089 12.6 11.4 0.12 12.1 11.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CPSF100_C PF13299.6 ETO16071.1 - 1.2 9.3 8.5 2.7 8.2 8.5 1.7 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF2076 PF09849.9 ETO16071.1 - 1.3 9.0 14.0 1.7 8.6 14.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) FAM60A PF15396.6 ETO16071.1 - 1.5 8.7 5.8 1.7 8.6 5.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A DNA_pol_phi PF04931.13 ETO16071.1 - 1.9 6.5 15.9 2.3 6.2 15.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO16071.1 - 3.1 7.0 15.9 3.7 6.8 15.9 1.1 1 0 0 1 1 1 0 NOA36 protein V_ATPase_I PF01496.19 ETO16071.1 - 4.2 5.1 7.3 4.8 5.0 7.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NPR3 PF03666.13 ETO16071.1 - 5.4 5.7 11.0 5.9 5.6 11.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ANAPC_CDC26 PF10471.9 ETO16071.1 - 6.6 7.6 10.5 6.8 7.6 5.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Presenilin PF01080.17 ETO16071.1 - 7.6 5.2 9.8 8.9 5.0 9.8 1.1 1 0 0 1 1 1 0 Presenilin UCH PF00443.29 ETO16072.1 - 4.9e-12 45.9 0.4 7.7e-12 45.2 0.4 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO16072.1 - 0.00058 19.5 0.0 0.00093 18.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase CAP_GLY PF01302.25 ETO16073.1 - 4.6e-15 55.4 1.9 8.4e-15 54.5 1.9 1.4 1 0 0 1 1 1 1 CAP-Gly domain FNIP PF05725.12 ETO16073.1 - 0.045 13.9 0.3 12 6.1 0.1 2.5 2 0 0 2 2 2 0 FNIP Repeat GNT-I PF03071.15 ETO16073.1 - 0.17 10.6 0.5 0.46 9.2 0.1 1.8 1 1 0 2 2 2 0 GNT-I family CAP_GLY PF01302.25 ETO16074.1 - 2.4e-63 210.0 14.3 1.2e-15 57.2 0.0 5.3 5 0 0 5 5 5 5 CAP-Gly domain YajC PF02699.15 ETO16074.1 - 0.11 12.4 1.4 5.6 6.9 0.0 2.9 3 0 0 3 3 3 0 Preprotein translocase subunit NifZ PF04319.13 ETO16074.1 - 0.31 10.9 6.6 12 5.7 0.1 4.2 5 0 0 5 5 5 0 NifZ domain CAP_GLY PF01302.25 ETO16075.1 - 1.4e-17 63.5 0.1 1.6e-13 50.5 0.0 2.3 2 0 0 2 2 2 2 CAP-Gly domain TMEM214 PF10151.9 ETO16075.1 - 0.2 10.1 2.8 0.29 9.5 2.8 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Nucleo_P87 PF07267.11 ETO16075.1 - 0.61 8.9 4.3 1 8.1 4.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RPN13_C PF16550.5 ETO16076.1 - 2.2e-24 85.8 3.5 2.2e-24 85.8 3.5 1.5 1 1 1 2 2 2 1 UCH-binding domain Mcm10 PF09332.11 ETO16076.1 - 0.073 12.5 8.5 0.083 12.3 8.5 1.1 1 0 0 1 1 1 0 Mcm10 replication factor Ndc1_Nup PF09531.10 ETO16076.1 - 0.63 8.7 6.3 0.63 8.7 6.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup TFIIA PF03153.13 ETO16076.1 - 1.1 9.2 17.6 1.1 9.2 17.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3597 PF12200.8 ETO16076.1 - 1.6 9.2 9.9 2.6 8.6 9.2 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF3597) DUF4106 PF13388.6 ETO16076.1 - 2.7 7.1 13.4 3 7.0 13.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) Use1 PF09753.9 ETO16076.1 - 3.9 7.1 11.7 4.9 6.8 11.2 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 Ten_N PF06484.12 ETO16076.1 - 5.8 6.7 8.9 6.8 6.5 8.9 1.1 1 0 0 1 1 1 0 Teneurin Intracellular Region SurA_N PF09312.11 ETO16076.1 - 8.5 6.5 10.1 10 6.2 9.1 1.6 1 1 0 1 1 1 0 SurA N-terminal domain Proteasom_Rpn13 PF04683.13 ETO16077.1 - 6.3e-19 68.3 2.9 1.1e-14 54.8 0.5 3.2 2 1 0 2 2 2 2 Proteasome complex subunit Rpn13 ubiquitin receptor Med1 PF10744.9 ETO16077.1 - 0.0087 15.2 0.3 0.011 14.8 0.3 1.4 1 0 0 1 1 1 1 Mediator of RNA polymerase II transcription subunit 1 SR-25 PF10500.9 ETO16077.1 - 2.1 7.9 10.2 1.3 8.6 4.3 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein KCNQ2_u3 PF16642.5 ETO16077.1 - 5.8 8.0 5.2 2.3 9.2 1.0 2.1 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 Macoilin PF09726.9 ETO16080.1 - 0.6 8.6 14.6 0.84 8.1 14.6 1.2 1 0 0 1 1 1 0 Macoilin family RPAP2_Rtr1 PF04181.13 ETO16080.1 - 0.77 10.1 5.1 0.34 11.3 0.2 2.5 2 0 0 2 2 2 0 Rtr1/RPAP2 family GREB1 PF15782.5 ETO16080.1 - 6.2 3.8 17.7 8.6 3.3 17.7 1.3 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PA26 PF04636.13 ETO16080.1 - 7.3 5.4 8.1 9.1 5.1 7.2 1.7 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) IL8 PF00048.20 ETO16081.1 - 0.0062 16.7 4.1 0.026 14.7 4.1 2.0 2 0 0 2 2 2 1 Small cytokines (intecrine/chemokine), interleukin-8 like HutP PF09021.11 ETO16081.1 - 0.12 12.7 0.1 0.27 11.5 0.1 1.6 1 0 0 1 1 1 0 HutP Pkinase PF00069.25 ETO16082.1 - 8.6e-35 120.4 2.0 1.7e-34 119.4 2.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16082.1 - 1.2e-09 37.8 0.1 5.8e-09 35.6 0.0 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase Exonuc_VII_L PF02601.15 ETO16083.1 - 0.18 11.3 3.8 0.22 11.1 3.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1772 PF08592.11 ETO16086.1 - 0.00024 21.5 0.6 0.00024 21.5 0.6 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF1772) Orf78 PF06024.12 ETO16086.1 - 0.29 11.4 0.0 0.29 11.4 0.0 3.1 4 1 0 4 4 4 0 Orf78 (ac78) ABC2_membrane_2 PF12679.7 ETO16086.1 - 5.1 6.3 19.1 2.6 7.2 0.9 2.4 2 1 0 2 2 2 0 ABC-2 family transporter protein SHIPPO-rpt PF07004.12 ETO16087.1 - 0.72 10.9 4.2 5.6 8.1 4.2 2.6 1 1 0 1 1 1 0 Sperm-tail PG-rich repeat His_Phos_1 PF00300.22 ETO16088.1 - 1.6e-27 96.5 0.0 2.1e-27 96.1 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) TPR_2 PF07719.17 ETO16089.1 - 0.021 14.9 8.7 2.3 8.5 0.0 5.2 4 1 1 5 5 5 0 Tetratricopeptide repeat Pox_A3L PF05288.11 ETO16089.1 - 0.085 12.9 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Poxvirus A3L Protein TPR_12 PF13424.6 ETO16089.1 - 0.12 12.6 2.5 5.3 7.4 0.0 3.4 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO16089.1 - 0.16 12.9 0.0 21 6.3 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Chorion_2 PF03964.15 ETO16089.1 - 3.5 8.5 13.1 0.51 11.2 6.2 2.4 2 0 0 2 2 2 0 Chorion family 2 DUF1676 PF07898.13 ETO16091.1 - 0.0025 17.9 1.2 0.0028 17.7 1.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1676) Cnd2 PF05786.14 ETO16091.1 - 0.0051 15.5 7.4 0.0073 15.0 7.4 1.3 1 0 0 1 1 1 1 Condensin complex subunit 2 7tm_6 PF02949.20 ETO16091.1 - 0.071 12.2 0.2 0.08 12.0 0.2 1.2 1 0 0 1 1 1 0 7tm Odorant receptor Drc1-Sld2 PF11719.8 ETO16091.1 - 0.17 11.4 21.5 0.19 11.2 21.5 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein Ribosomal_S2 PF00318.20 ETO16091.1 - 0.24 10.6 6.9 0.29 10.3 6.9 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 Sporozoite_P67 PF05642.11 ETO16091.1 - 0.44 8.6 4.2 0.45 8.5 4.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TRAP_alpha PF03896.16 ETO16091.1 - 0.52 9.5 6.5 0.54 9.4 6.5 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Serinc PF03348.15 ETO16091.1 - 0.57 9.1 3.1 0.59 9.0 3.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_polI_A34 PF08208.11 ETO16091.1 - 0.59 10.2 15.5 0.64 10.1 15.5 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Peroxin-13_N PF04088.13 ETO16091.1 - 0.66 10.2 4.0 0.6 10.4 3.0 1.3 1 1 0 1 1 1 0 Peroxin 13, N-terminal region Ribosomal_60s PF00428.19 ETO16091.1 - 1.6 9.4 9.2 0.15 12.6 4.8 1.6 2 0 0 2 2 1 0 60s Acidic ribosomal protein HA2 PF04408.23 ETO16091.1 - 2 8.8 6.3 2.7 8.3 6.2 1.5 1 1 0 1 1 1 0 Helicase associated domain (HA2) AP3D1 PF06375.11 ETO16091.1 - 3.1 8.0 22.7 0.17 12.1 16.1 2.1 1 1 1 2 2 2 0 AP-3 complex subunit delta-1 YL1 PF05764.13 ETO16091.1 - 3.2 7.8 24.4 4.9 7.2 24.4 1.4 1 1 0 1 1 1 0 YL1 nuclear protein Connexin PF00029.19 ETO16091.1 - 5.2 6.8 9.4 5.8 6.6 9.4 1.3 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 ETO16091.1 - 5.7 5.1 17.6 5.9 5.0 17.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Orf78 PF06024.12 ETO16091.1 - 6.3 7.2 7.6 18 5.7 7.5 2.0 1 1 0 1 1 1 0 Orf78 (ac78) Sec62 PF03839.16 ETO16091.1 - 7.5 6.0 12.8 8.4 5.8 12.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Ferlin_C PF16165.5 ETO16091.1 - 8.6 6.3 13.2 11 5.9 13.2 1.2 1 0 0 1 1 1 0 Ferlin C-terminus Med2 PF11214.8 ETO16091.1 - 9.1 6.5 18.3 0.24 11.5 9.7 2.1 1 1 0 2 2 2 0 Mediator complex subunit 2 GOLD_2 PF13897.6 ETO16091.1 - 9.8 6.7 8.7 8.7 6.8 7.8 1.4 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking EF-hand_1 PF00036.32 ETO16092.1 - 4.3e-11 41.5 9.4 2.1e-05 23.7 1.1 2.5 2 1 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO16092.1 - 7.2e-11 42.4 4.9 1.7e-10 41.2 4.9 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO16092.1 - 1.2e-09 37.3 5.7 0.00033 20.3 0.5 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO16092.1 - 6.3e-06 25.4 6.7 0.00079 18.8 0.7 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO16092.1 - 0.00038 20.3 2.5 0.00038 20.3 2.5 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_10 PF14788.6 ETO16092.1 - 0.046 13.6 2.8 4.1 7.3 0.1 2.4 2 0 0 2 2 2 0 EF hand CitT PF12431.8 ETO16092.1 - 0.15 12.5 0.3 0.42 11.0 0.3 1.8 1 0 0 1 1 1 0 Transcriptional regulator Caleosin PF05042.13 ETO16092.1 - 0.21 11.5 1.7 2.3 8.1 0.3 2.1 1 1 1 2 2 2 0 Caleosin related protein SPARC_Ca_bdg PF10591.9 ETO16092.1 - 0.4 11.0 13.9 3.9 7.8 13.9 2.1 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region YABBY PF04690.13 ETO16092.1 - 1.8 9.1 8.0 2.5 8.7 8.0 1.2 1 0 0 1 1 1 0 YABBY protein Dsh_C PF12316.8 ETO16092.1 - 4.1 7.8 6.4 4.7 7.6 6.4 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Polyoma_lg_T_C PF06431.11 ETO16093.1 - 0.017 14.0 0.3 0.025 13.5 0.3 1.3 1 0 0 1 1 1 0 Polyomavirus large T antigen C-terminus SDA1 PF05285.12 ETO16093.1 - 0.035 13.5 6.3 0.045 13.2 6.3 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 ETO16093.1 - 0.051 11.7 8.1 0.066 11.3 8.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi IMUP PF15761.5 ETO16093.1 - 5.9 7.6 9.3 1.5 9.5 5.6 1.8 2 0 0 2 2 2 0 Immortalisation up-regulated protein Putative_PNPOx PF01243.20 ETO16094.1 - 3.6e-14 52.7 0.0 1.2e-13 51.1 0.0 1.8 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyridox_oxase_2 PF12766.7 ETO16094.1 - 0.00012 22.7 0.1 0.00058 20.4 0.0 2.3 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase WD40 PF00400.32 ETO16095.1 - 8.1e-35 118.3 21.5 1.2e-06 29.1 1.2 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16095.1 - 3.6e-13 49.6 5.7 0.00068 19.9 0.1 6.2 5 1 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16095.1 - 1.8e-12 46.7 3.7 0.011 14.4 0.0 5.1 3 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16095.1 - 3.2e-06 26.7 5.8 0.0041 16.5 0.3 4.8 2 2 4 6 6 6 3 WD40-like domain DUF2796 PF10986.8 ETO16097.1 - 0.017 15.1 10.7 0.033 14.1 10.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Pox_Ag35 PF03286.14 ETO16097.1 - 0.078 12.8 14.7 0.15 11.9 14.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein POX PF07526.11 ETO16097.1 - 0.15 12.6 3.2 0.32 11.5 1.8 2.1 2 0 0 2 2 2 0 Associated with HOX Zip PF02535.22 ETO16097.1 - 0.17 11.1 1.1 0.24 10.6 1.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO16097.1 - 0.29 9.4 5.7 0.42 8.8 5.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Ferlin_C PF16165.5 ETO16097.1 - 0.46 10.4 2.9 0.98 9.4 2.9 1.5 1 0 0 1 1 1 0 Ferlin C-terminus FAM176 PF14851.6 ETO16097.1 - 0.52 10.0 8.1 1 9.0 8.1 1.4 1 0 0 1 1 1 0 FAM176 family DUF3464 PF11947.8 ETO16097.1 - 6.7 6.4 7.8 16 5.2 7.8 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Kelch_6 PF13964.6 ETO16099.1 - 8.7e-06 25.8 0.3 0.38 11.1 0.0 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO16099.1 - 9.1e-05 22.0 0.8 1.7 8.3 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO16099.1 - 0.00044 20.1 1.5 1.6 8.9 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO16099.1 - 0.00055 19.9 0.0 0.013 15.5 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO16099.1 - 0.0084 15.3 0.0 1.3 8.1 0.0 2.2 2 0 0 2 2 2 2 Protein N-terminal asparagine amidohydrolase Kelch_5 PF13854.6 ETO16099.1 - 0.02 14.9 2.5 7.8 6.6 0.7 3.5 3 1 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO16100.1 - 1.1e-33 114.7 13.0 1.9e-09 38.0 0.5 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16100.1 - 1.1e-13 51.2 2.8 0.0039 17.5 0.1 4.7 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16100.1 - 4.4e-08 32.5 0.3 1.4 7.8 0.0 5.0 2 2 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Glyoxal_oxid_N PF07250.11 ETO16100.1 - 0.0058 15.8 0.1 0.013 14.7 0.0 1.7 2 0 0 2 2 2 1 Glyoxal oxidase N-terminus DUF1828 PF08861.10 ETO16100.1 - 0.02 15.1 0.3 4.6 7.6 0.0 3.2 2 1 1 3 3 3 0 Domain of unknown function DUF1828 LOR PF04525.12 ETO16100.1 - 0.056 13.0 0.4 0.62 9.6 0.0 2.2 2 1 0 2 2 2 0 LURP-one-related CPT_N PF16484.5 ETO16100.1 - 0.058 13.4 0.2 0.15 12.0 0.2 1.7 1 0 0 1 1 1 0 Carnitine O-palmitoyltransferase N-terminus Kelch_1 PF01344.25 ETO16101.1 - 0.0016 18.0 3.6 0.074 12.7 0.1 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 ETO16101.1 - 0.012 15.5 5.7 0.55 10.3 0.1 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO16101.1 - 0.48 10.8 6.0 16 5.9 0.1 4.0 5 0 0 5 5 5 0 Kelch motif PIEZO PF15917.5 ETO16103.1 - 0.09 12.3 5.7 0.14 11.6 5.7 1.3 1 0 0 1 1 1 0 Piezo Pkinase PF00069.25 ETO16104.1 - 7.5e-37 127.1 0.0 3.7e-25 88.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16104.1 - 4.6e-26 91.7 0.0 5.6e-19 68.4 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase PMG PF05287.12 ETO16104.1 - 0.00065 19.8 0.6 0.00089 19.3 0.6 1.1 1 0 0 1 1 1 1 PMG protein SQHop_cyclase_N PF13249.6 ETO16104.1 - 0.0033 16.6 0.0 0.0046 16.1 0.0 1.2 1 0 0 1 1 1 1 Squalene-hopene cyclase N-terminal domain APH PF01636.23 ETO16104.1 - 0.012 15.5 0.0 0.023 14.6 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family PIP49_C PF12260.8 ETO16104.1 - 0.022 14.4 0.0 0.032 13.9 0.0 1.2 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 FANCA_interact PF15751.5 ETO16105.1 - 0.1 13.1 0.3 0.24 11.9 0.3 1.6 1 0 0 1 1 1 0 FAAP20 FANCA interaction domain Acyl-ACP_TE PF01643.17 ETO16106.1 - 0.0029 16.9 0.8 0.0078 15.5 0.9 1.8 1 1 0 1 1 1 1 Acyl-ACP thioesterase BTB PF00651.31 ETO16107.1 - 1.5e-21 76.7 3.5 8.2e-21 74.3 0.2 2.7 2 0 0 2 2 2 1 BTB/POZ domain Transglut_core PF01841.19 ETO16109.1 - 0.00038 20.9 0.0 0.0039 17.6 0.0 2.2 2 0 0 2 2 2 1 Transglutaminase-like superfamily BHD_3 PF10405.9 ETO16110.1 - 1.8e-23 82.7 0.0 4.6e-23 81.4 0.0 1.7 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 3 BHD_1 PF10403.9 ETO16110.1 - 7.1e-13 48.2 0.5 1.6e-12 47.1 0.5 1.6 1 0 0 1 1 1 1 Rad4 beta-hairpin domain 1 Rad4 PF03835.15 ETO16110.1 - 3.7e-12 46.2 0.3 7e-12 45.2 0.3 1.4 1 0 0 1 1 1 1 Rad4 transglutaminase-like domain BHD_2 PF10404.9 ETO16110.1 - 4.5e-07 30.7 1.7 4.3e-05 24.4 1.7 2.5 1 1 0 1 1 1 1 Rad4 beta-hairpin domain 2 Pyr_redox_dim PF02852.22 ETO16111.1 - 5.1e-37 126.5 0.0 7.4e-37 126.0 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 ETO16111.1 - 2.1e-06 27.2 0.0 3.9e-06 26.3 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO16112.1 - 2.9e-37 128.5 2.0 3.5e-37 128.2 2.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO16112.1 - 3.7e-20 72.3 1.3 5.1e-20 71.8 0.3 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO16112.1 - 1e-07 31.5 1.0 3.6e-07 29.8 1.0 1.8 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO16112.1 - 3.7e-07 29.6 0.3 0.0017 17.6 0.1 2.0 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) AlaDh_PNT_C PF01262.21 ETO16112.1 - 0.0011 18.4 0.4 0.0016 17.7 0.4 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain HI0933_like PF03486.14 ETO16112.1 - 0.0011 17.7 5.0 0.93 8.1 0.1 3.0 2 1 1 3 3 3 2 HI0933-like protein 3HCDH_N PF02737.18 ETO16112.1 - 0.0037 17.2 0.5 0.011 15.7 0.2 1.8 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Amino_oxidase PF01593.24 ETO16112.1 - 0.0052 16.1 0.1 0.019 14.3 0.0 1.8 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase Mqo PF06039.15 ETO16112.1 - 0.042 12.4 3.4 0.67 8.4 0.1 2.4 2 1 1 3 3 3 0 Malate:quinone oxidoreductase (Mqo) FAD_binding_3 PF01494.19 ETO16112.1 - 0.068 12.4 2.5 0.3 10.3 0.4 2.3 3 0 0 3 3 3 0 FAD binding domain UDPG_MGDP_dh_N PF03721.14 ETO16112.1 - 0.19 11.3 1.9 0.21 11.1 0.3 1.9 2 1 0 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DAO PF01266.24 ETO16112.1 - 0.2 11.2 5.8 4 6.9 0.9 2.9 3 0 0 3 3 3 0 FAD dependent oxidoreductase GIDA PF01134.22 ETO16112.1 - 0.44 9.6 2.8 5.7 5.9 0.2 2.4 2 1 0 2 2 2 0 Glucose inhibited division protein A FAD_binding_2 PF00890.24 ETO16112.1 - 1.1 8.2 5.0 3.2 6.8 0.1 2.6 2 1 1 3 3 3 0 FAD binding domain ArfGap PF01412.18 ETO16114.1 - 1e-35 122.3 1.4 9.3e-35 119.2 1.4 2.4 1 1 0 1 1 1 1 Putative GTPase activating protein for Arf CRA PF06589.11 ETO16114.1 - 0.11 12.6 1.5 3.4 7.8 0.0 2.2 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) TPR_2 PF07719.17 ETO16115.1 - 2.2e-24 83.5 18.2 6.5e-06 25.9 0.4 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16115.1 - 1.2e-23 81.9 24.0 1.1e-05 25.0 5.1 7.2 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO16115.1 - 2.6e-23 80.2 16.5 6.8e-08 32.1 0.5 5.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO16115.1 - 5.6e-23 79.6 13.9 4.5e-07 29.8 0.2 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO16115.1 - 4.2e-13 48.9 0.0 0.24 12.3 0.0 6.4 3 2 4 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO16115.1 - 1.5e-12 47.6 15.7 2.6e-06 27.6 4.0 5.3 3 3 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO16115.1 - 3.6e-12 45.8 11.0 2.9e-06 26.9 0.0 5.6 4 2 2 6 6 6 2 TPR repeat TPR_19 PF14559.6 ETO16115.1 - 3.1e-11 43.6 0.4 0.0015 19.0 0.0 4.5 2 2 4 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO16115.1 - 2.3e-10 39.8 1.6 0.0055 16.7 0.3 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TAtT PF16811.5 ETO16115.1 - 3.1e-05 23.4 0.5 0.00037 19.9 0.2 2.2 1 1 1 2 2 2 1 TRAP transporter T-component TPR_9 PF13371.6 ETO16115.1 - 7.3e-05 22.8 0.0 0.86 9.8 0.0 3.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO16115.1 - 0.00034 21.2 0.0 7.1 7.4 0.0 4.0 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO16115.1 - 0.0013 18.6 17.6 0.24 11.3 1.8 5.8 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO16115.1 - 0.0018 18.8 1.8 14 6.6 0.1 4.9 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO16115.1 - 0.0033 16.9 1.0 0.08 12.3 0.1 2.3 1 1 0 2 2 2 1 MalT-like TPR region Fis1_TPR_C PF14853.6 ETO16115.1 - 0.018 15.1 4.5 94 3.2 0.0 5.3 4 1 1 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 ETO16115.1 - 0.049 14.0 0.4 8.8 6.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPPII_N PF12583.8 ETO16115.1 - 0.057 14.0 4.1 9.2 6.8 0.0 3.2 3 0 0 3 3 3 0 Tripeptidyl peptidase II N terminal DDE_Tnp_1_7 PF13843.6 ETO16116.1 - 0.04 13.2 0.1 0.048 12.9 0.1 1.1 1 0 0 1 1 1 0 Transposase IS4 DUF4618 PF15397.6 ETO16118.1 - 0.02 14.4 0.6 0.028 13.8 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) DUF4473 PF14747.6 ETO16118.1 - 0.088 13.4 0.1 0.22 12.1 0.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4473) DUF5507 PF17612.2 ETO16119.1 - 1.1 8.9 7.6 0.061 13.0 1.2 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5507) RCC1 PF00415.18 ETO16120.1 - 1.7e-35 121.4 18.9 3.9e-13 49.8 0.1 5.9 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO16120.1 - 6.4e-23 80.0 24.9 6.2e-08 32.2 1.5 6.4 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat Menin PF05053.13 ETO16120.1 - 0.27 9.6 3.7 0.34 9.2 3.7 1.1 1 0 0 1 1 1 0 Menin NOA36 PF06524.12 ETO16120.1 - 0.28 10.5 6.7 2.1 7.6 0.4 2.5 3 0 0 3 3 3 0 NOA36 protein Secretin_N_2 PF07655.13 ETO16120.1 - 1.3 9.6 17.2 3.3 8.3 17.2 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Orf78 PF06024.12 ETO16120.1 - 8.1 6.8 7.3 18 5.7 7.3 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Paf1 PF03985.13 ETO16121.1 - 0.00041 19.5 10.7 0.00045 19.4 10.7 1.0 1 0 0 1 1 1 1 Paf1 BUD22 PF09073.10 ETO16121.1 - 0.0047 16.3 13.7 0.0058 16.0 13.7 1.0 1 0 0 1 1 1 1 BUD22 V_ATPase_I PF01496.19 ETO16121.1 - 0.0065 14.5 3.1 0.007 14.4 3.1 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 ETO16121.1 - 0.0067 16.8 9.0 0.0088 16.4 9.0 1.1 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 TFIIA PF03153.13 ETO16121.1 - 0.0079 16.2 9.9 0.0088 16.1 9.9 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pox_Ag35 PF03286.14 ETO16121.1 - 0.013 15.3 14.7 0.018 14.8 14.7 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2722 PF10846.8 ETO16121.1 - 0.022 13.7 6.1 0.027 13.4 6.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Afi1 PF07792.12 ETO16121.1 - 0.036 14.5 8.7 0.05 14.1 8.7 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RPN2_C PF18004.1 ETO16121.1 - 0.066 13.1 13.7 0.084 12.8 13.7 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cwf_Cwc_15 PF04889.12 ETO16121.1 - 0.11 12.2 21.0 0.14 11.8 21.0 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein AgrB PF04647.15 ETO16121.1 - 0.13 11.5 0.0 0.18 11.1 0.0 1.2 1 0 0 1 1 1 0 Accessory gene regulator B MMM1 PF10296.9 ETO16121.1 - 0.14 11.2 1.8 0.18 10.8 1.8 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 Connexin PF00029.19 ETO16121.1 - 0.15 11.8 1.3 0.2 11.4 1.3 1.2 1 0 0 1 1 1 0 Connexin TMEMspv1-c74-12 PF11044.8 ETO16121.1 - 0.17 11.9 2.0 0.3 11.1 2.0 1.4 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF913 PF06025.12 ETO16121.1 - 0.2 10.6 2.9 0.22 10.5 2.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF5523 PF17661.1 ETO16121.1 - 0.23 11.1 18.4 0.29 10.8 18.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) CobT PF06213.12 ETO16121.1 - 0.42 10.0 16.9 0.43 9.9 16.9 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 ETO16121.1 - 0.48 9.6 1.6 0.6 9.3 1.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PPP4R2 PF09184.11 ETO16121.1 - 0.81 9.2 21.8 1 8.9 21.8 1.1 1 0 0 1 1 1 0 PPP4R2 Spore_coat_CotO PF14153.6 ETO16121.1 - 3.3 7.6 14.8 4.1 7.3 14.8 1.1 1 0 0 1 1 1 0 Spore coat protein CotO PTPRCAP PF15713.5 ETO16121.1 - 3.3 8.0 24.3 5.1 7.4 24.3 1.4 1 1 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Glucos_trans_II PF14264.6 ETO16123.1 - 0.02 14.2 4.1 0.027 13.8 4.1 1.2 1 0 0 1 1 1 0 Glucosyl transferase GtrII TMEM51 PF15345.6 ETO16123.1 - 0.17 11.7 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Transmembrane protein 51 WD40 PF00400.32 ETO16124.1 - 4.7e-25 87.4 4.0 4.1e-10 40.1 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16124.1 - 4.5e-07 30.1 0.1 0.023 15.0 0.0 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16124.1 - 2e-05 23.5 0.1 0.024 13.3 0.0 3.2 3 1 1 4 4 4 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO16124.1 - 8e-05 22.6 0.0 0.037 13.9 0.0 2.3 2 0 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO16124.1 - 0.00032 19.8 0.0 0.23 10.4 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO16124.1 - 0.0034 16.2 0.3 0.019 13.7 0.2 2.0 1 1 1 2 2 2 1 Nup133 N terminal like DUF727 PF05303.12 ETO16124.1 - 0.1 12.7 0.0 0.26 11.4 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF727) zf-4CXXC_R1 PF10497.9 ETO16125.1 - 1.3e-09 38.2 16.6 2.8e-09 37.1 16.6 1.6 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 LIG3_BRCT PF16759.5 ETO16125.1 - 0.0077 16.5 0.5 0.02 15.2 0.1 2.0 2 0 0 2 2 2 1 DNA ligase 3 BRCT domain RabGAP-TBC PF00566.18 ETO16126.1 - 0.55 9.8 4.7 0.65 9.6 4.7 1.0 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Mannitol_dh PF01232.23 ETO16128.1 - 0.0094 16.1 0.0 0.03 14.5 0.0 1.8 2 0 0 2 2 2 1 Mannitol dehydrogenase Rossmann domain Fer2_BFD PF04324.15 ETO16128.1 - 0.02 15.3 0.3 0.18 12.2 0.1 2.5 2 0 0 2 2 2 0 BFD-like [2Fe-2S] binding domain CUE PF02845.16 ETO16128.1 - 0.11 12.2 0.2 0.23 11.2 0.2 1.5 1 0 0 1 1 1 0 CUE domain Acyl_transf_3 PF01757.22 ETO16129.1 - 0.0065 15.6 0.7 0.011 14.8 0.7 1.3 1 0 0 1 1 1 1 Acyltransferase family WD40 PF00400.32 ETO16130.1 - 1.3e-24 86.0 7.9 2.8e-08 34.3 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16130.1 - 3.1e-13 49.8 0.5 0.00014 22.1 0.1 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16130.1 - 1.7e-06 27.6 0.3 2e-05 24.1 0.2 2.0 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO16130.1 - 5e-06 25.4 0.7 0.32 9.6 0.1 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO16130.1 - 2.1e-05 23.6 0.1 0.93 8.4 0.0 3.4 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ETO16130.1 - 0.011 14.7 1.8 2.8 6.8 0.1 2.9 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain RSN1_TM PF13967.6 ETO16131.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport WBP-1 PF11669.8 ETO16131.1 - 0.53 10.9 4.5 7.7 7.2 4.4 2.4 1 1 0 1 1 1 0 WW domain-binding protein 1 DUF5344 PF17279.2 ETO16132.1 - 0.018 15.6 5.8 0.093 13.3 3.4 3.5 1 1 1 2 2 2 0 Family of unknown function (DUF5344) GAT PF03127.14 ETO16132.1 - 0.033 14.5 0.7 0.033 14.5 0.7 3.3 3 0 0 3 3 3 0 GAT domain TPR_5 PF12688.7 ETO16132.1 - 0.095 12.9 0.1 0.25 11.6 0.1 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat EF-hand_6 PF13405.6 ETO16132.1 - 0.13 12.3 1.4 16 5.8 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain Orf78 PF06024.12 ETO16133.1 - 1.1 9.6 3.3 3.7 7.9 0.6 2.4 2 0 0 2 2 2 0 Orf78 (ac78) DOR PF14839.6 ETO16134.1 - 0.48 10.4 7.3 0.62 10.0 7.3 1.1 1 0 0 1 1 1 0 DOR family CLN3 PF02487.17 ETO16134.1 - 0.49 9.4 3.1 0.56 9.2 3.1 1.1 1 0 0 1 1 1 0 CLN3 protein AP3D1 PF06375.11 ETO16134.1 - 0.51 10.6 11.0 0.73 10.1 11.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Collagen PF01391.18 ETO16135.1 - 1.9e-05 24.4 33.4 1.9e-05 24.4 33.4 2.3 1 1 1 2 2 2 1 Collagen triple helix repeat (20 copies) UCH PF00443.29 ETO16136.1 - 7.3e-34 117.4 0.3 7.3e-34 117.4 0.3 3.6 3 2 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO16136.1 - 9.5e-29 101.0 3.4 3.3e-28 99.2 3.4 2.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase EF-hand_7 PF13499.6 ETO16136.1 - 0.0092 16.4 0.4 0.15 12.6 0.0 3.5 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO16136.1 - 0.0096 15.8 0.1 0.12 12.4 0.1 3.0 2 0 0 2 2 2 1 EF-hand domain Drf_GBD PF06371.13 ETO16136.1 - 0.011 15.3 2.5 0.024 14.2 0.1 3.0 3 0 0 3 3 3 0 Diaphanous GTPase-binding Domain Imm70 PF15601.6 ETO16136.1 - 0.073 12.6 0.0 0.23 11.0 0.0 1.8 1 0 0 1 1 1 0 Immunity protein 70 EF_assoc_2 PF08356.12 ETO16136.1 - 0.11 12.5 0.0 0.36 10.9 0.0 1.8 1 0 0 1 1 1 0 EF hand associated cNMP_binding PF00027.29 ETO16138.1 - 2.7e-20 72.2 0.0 4e-20 71.7 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain ATP-gua_Ptrans PF00217.19 ETO16138.1 - 0.18 11.3 0.0 0.23 10.9 0.0 1.1 1 0 0 1 1 1 0 ATP:guanido phosphotransferase, C-terminal catalytic domain 2_5_RNA_ligase2 PF13563.6 ETO16139.1 - 0.015 15.2 0.0 0.034 14.1 0.0 1.6 2 0 0 2 2 2 0 2'-5' RNA ligase superfamily VPS9 PF02204.18 ETO16140.1 - 2.7e-09 37.2 0.0 8.5e-09 35.6 0.0 1.9 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain TPR_2 PF07719.17 ETO16140.1 - 0.35 11.1 2.4 5.6 7.3 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat MbeD_MobD PF04899.12 ETO16140.1 - 0.85 9.8 6.4 0.33 11.1 0.9 2.9 3 0 0 3 3 3 0 MbeD/MobD like LRAT PF04970.13 ETO16141.1 - 1.6e-10 41.4 1.2 1.6e-10 41.4 1.2 1.9 2 0 0 2 2 2 1 Lecithin retinol acyltransferase VPS13_C PF16909.5 ETO16141.1 - 0.21 11.3 1.5 1.3 8.7 0.0 2.6 2 1 1 3 3 3 0 Vacuolar-sorting-associated 13 protein C-terminal NPR3 PF03666.13 ETO16142.1 - 0.0035 16.2 4.7 0.0035 16.2 4.7 2.4 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 RSB_motif PF16294.5 ETO16142.1 - 0.0042 17.3 4.0 0.0042 17.3 4.0 3.5 3 1 0 3 3 2 1 RNSP1-SAP18 binding (RSB) motif DUF913 PF06025.12 ETO16142.1 - 0.0043 16.1 2.4 0.0043 16.1 2.4 2.6 2 1 1 3 3 3 1 Domain of Unknown Function (DUF913) EMC3_TMCO1 PF01956.16 ETO16142.1 - 0.021 14.6 0.2 0.021 14.6 0.2 2.5 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Orf78 PF06024.12 ETO16142.1 - 0.024 14.9 4.3 1.2 9.5 0.0 3.0 2 1 0 2 2 2 0 Orf78 (ac78) Serinc PF03348.15 ETO16142.1 - 0.026 13.5 10.9 0.059 12.3 9.9 1.9 1 1 1 2 2 2 0 Serine incorporator (Serinc) AgrB PF04647.15 ETO16142.1 - 0.084 12.2 3.3 0.22 10.8 0.2 2.4 2 0 0 2 2 2 0 Accessory gene regulator B CENP-B_dimeris PF09026.10 ETO16142.1 - 0.12 12.8 8.9 11 6.5 0.0 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF5308 PF17233.2 ETO16142.1 - 0.21 11.8 3.2 0.7 10.1 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5308) 7TM_GPCR_Sru PF10322.9 ETO16142.1 - 0.39 10.0 3.9 0.23 10.7 0.8 2.0 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru DUF4410 PF14366.6 ETO16142.1 - 0.6 10.0 0.1 0.6 10.0 0.1 2.6 3 0 0 3 3 2 0 Domain of unknown function (DUF4410) SID-1_RNA_chan PF13965.6 ETO16142.1 - 0.73 8.2 6.9 1.1 7.6 6.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Nucleoside_tran PF01733.18 ETO16142.1 - 0.89 8.9 6.8 0.2 11.0 2.6 1.9 1 1 1 2 2 2 0 Nucleoside transporter Sec62 PF03839.16 ETO16142.1 - 2.7 7.4 19.4 0.27 10.7 6.7 3.0 3 0 0 3 3 3 0 Translocation protein Sec62 PBP1_TM PF14812.6 ETO16142.1 - 3 8.3 38.9 0.39 11.1 19.4 3.9 3 2 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 ETO16142.1 - 3.1 7.8 19.4 0.13 12.3 6.0 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4637 PF15470.6 ETO16142.1 - 6.6 6.4 13.4 28 4.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) CPSF100_C PF13299.6 ETO16142.1 - 6.8 6.8 18.5 9.3 6.4 5.7 3.4 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal BT1 PF03092.16 ETO16142.1 - 6.9 4.8 7.2 0.41 8.8 0.9 1.9 1 1 1 2 2 2 0 BT1 family ENTH PF01417.20 ETO16143.1 - 1.5e-31 109.0 0.0 1.9e-31 108.7 0.0 1.1 1 0 0 1 1 1 1 ENTH domain ANTH PF07651.16 ETO16143.1 - 5.6e-08 32.1 0.0 6.6e-08 31.9 0.0 1.0 1 0 0 1 1 1 1 ANTH domain VHS PF00790.19 ETO16143.1 - 0.015 15.2 0.0 0.018 14.9 0.0 1.1 1 0 0 1 1 1 0 VHS domain V_ATPase_I PF01496.19 ETO16144.1 - 0.035 12.0 0.2 0.042 11.8 0.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SKA1 PF07160.12 ETO16144.1 - 0.046 13.6 4.9 0.34 10.7 1.1 2.0 1 1 0 2 2 2 0 Spindle and kinetochore-associated protein 1 Lyase_catalyt PF09093.11 ETO16144.1 - 0.091 11.9 0.5 0.12 11.5 0.5 1.1 1 0 0 1 1 1 0 Lyase, catalytic CENP-K PF11802.8 ETO16144.1 - 0.27 10.8 8.7 0.21 11.1 4.6 1.9 1 1 1 2 2 2 0 Centromere-associated protein K Sec2p PF06428.11 ETO16144.1 - 0.91 9.5 6.5 0.2 11.6 1.7 2.3 3 1 0 3 3 3 0 GDP/GTP exchange factor Sec2p CENP-Q PF13094.6 ETO16144.1 - 5.8 7.1 9.9 4.6 7.4 2.5 2.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit CDC45 PF02724.14 ETO16145.1 - 6.2e-05 21.5 1.9 7e-05 21.3 1.9 1.1 1 0 0 1 1 1 1 CDC45-like protein MFS_1_like PF12832.7 ETO16145.1 - 0.0024 16.8 1.7 0.0029 16.5 1.4 1.3 1 1 0 1 1 1 1 MFS_1 like family RRN3 PF05327.11 ETO16145.1 - 0.089 11.3 8.9 0.14 10.6 8.9 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Secretin_N_2 PF07655.13 ETO16145.1 - 0.18 12.4 15.3 2.4 8.8 9.1 3.2 3 0 0 3 3 3 0 Secretin N-terminal domain Sigma70_ner PF04546.13 ETO16145.1 - 0.22 11.4 7.1 0.34 10.7 7.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region GCIP PF13324.6 ETO16145.1 - 0.29 10.7 6.8 0.53 9.9 6.8 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Cwf_Cwc_15 PF04889.12 ETO16145.1 - 0.55 9.9 19.8 0.92 9.2 19.8 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CPSF100_C PF13299.6 ETO16145.1 - 3.5 7.8 8.0 0.26 11.5 3.2 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Sporozoite_P67 PF05642.11 ETO16145.1 - 4.6 5.2 12.1 7.3 4.5 12.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF913 PF06025.12 ETO16145.1 - 5 6.0 6.3 48 2.8 8.2 1.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DNA_pol_phi PF04931.13 ETO16145.1 - 6.5 4.7 23.0 9.9 4.1 23.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi TRAP_alpha PF03896.16 ETO16145.1 - 8.8 5.4 9.4 16 4.6 9.4 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SR-25 PF10500.9 ETO16146.1 - 1.7 8.2 5.2 8.2 6.0 0.5 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein WW PF00397.26 ETO16146.1 - 4.4 7.5 7.0 56 3.9 0.5 3.7 4 0 0 4 4 4 0 WW domain Anoctamin PF04547.12 ETO16147.1 - 6.7e-40 137.3 21.5 8.4e-40 136.9 21.5 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel HSP90 PF00183.18 ETO16149.1 - 1.3e-62 212.4 30.4 7.6e-35 120.8 8.5 2.7 1 1 1 2 2 2 2 Hsp90 protein Tmemb_9 PF05434.11 ETO16149.1 - 0.047 13.6 1.7 0.085 12.8 0.0 2.2 3 0 0 3 3 3 0 TMEM9 RST PF12174.8 ETO16149.1 - 0.051 13.5 0.5 0.051 13.5 0.5 2.0 2 0 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain RPAP2_Rtr1 PF04181.13 ETO16150.1 - 1.4 9.3 7.0 0.5 10.7 3.1 2.1 2 0 0 2 2 2 0 Rtr1/RPAP2 family HSP90 PF00183.18 ETO16152.1 - 7.1e-35 120.9 3.9 8.8e-35 120.6 3.9 1.0 1 0 0 1 1 1 1 Hsp90 protein TRIQK PF15168.6 ETO16152.1 - 0.039 13.9 0.8 0.19 11.6 0.0 2.1 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family BAP PF06639.11 ETO16152.1 - 0.065 13.6 2.5 0.23 11.8 0.3 2.2 2 0 0 2 2 2 0 Basal layer antifungal peptide (BAP) DUF19 PF01579.18 ETO16152.1 - 0.077 12.8 2.6 0.18 11.6 2.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF19) G0-G1_switch_2 PF15103.6 ETO16152.1 - 0.19 12.2 2.2 1.3 9.5 0.3 2.6 1 1 1 2 2 2 0 G0/G1 switch protein 2 DUF3306 PF11748.8 ETO16154.1 - 0.44 11.4 8.9 0.25 12.2 2.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) FAM176 PF14851.6 ETO16154.1 - 0.83 9.3 9.5 0.33 10.6 0.4 2.5 2 0 0 2 2 2 0 FAM176 family Dynamin_N PF00350.23 ETO16154.1 - 6.7 6.7 10.0 0.54 10.3 0.5 3.0 3 0 0 3 3 3 0 Dynamin family AAA PF00004.29 ETO16155.1 - 5.6e-07 30.0 0.2 1.4e-06 28.8 0.1 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO16155.1 - 0.0053 16.8 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO16155.1 - 0.0084 16.5 0.0 0.025 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ETO16155.1 - 0.0098 16.3 0.0 0.041 14.3 0.0 1.9 2 0 0 2 2 2 1 RNA helicase DUF815 PF05673.13 ETO16155.1 - 0.01 15.0 0.0 0.027 13.6 0.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF815) Mg_chelatase PF01078.21 ETO16155.1 - 0.014 14.8 0.1 0.025 13.9 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ETO16155.1 - 0.017 14.9 0.0 0.04 13.7 0.0 1.6 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ETO16155.1 - 0.028 14.6 0.0 0.049 13.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO16155.1 - 0.063 13.0 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_7 PF12775.7 ETO16155.1 - 0.074 12.6 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ETO16155.1 - 0.094 13.0 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO16155.1 - 0.12 12.9 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF3798 PF12683.7 ETO16155.1 - 0.12 11.7 0.0 0.17 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3798) IstB_IS21 PF01695.17 ETO16155.1 - 0.13 12.0 0.2 0.45 10.2 0.0 1.9 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA_17 PF13207.6 ETO16155.1 - 0.14 12.6 0.1 0.32 11.4 0.0 1.6 2 0 0 2 2 2 0 AAA domain Parvo_NS1 PF01057.17 ETO16155.1 - 0.18 10.9 0.0 0.31 10.1 0.0 1.3 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_28 PF13521.6 ETO16155.1 - 0.19 12.0 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain BSP_II PF05432.11 ETO16157.1 - 0.22 11.2 1.5 0.29 10.8 1.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Pkinase PF00069.25 ETO16158.1 - 4.7e-05 22.9 0.1 6.8e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Gemini_V2 PF01524.17 ETO16159.1 - 0.13 12.5 0.1 0.17 12.1 0.1 1.3 1 0 0 1 1 1 0 Geminivirus V2 protein WD40 PF00400.32 ETO16160.1 - 3e-07 31.0 0.6 0.0019 19.0 0.0 2.8 2 1 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16160.1 - 0.0011 19.2 0.0 0.026 14.8 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WAC_Acf1_DNA_bd PF10537.9 ETO16161.1 - 0.13 12.8 1.7 3.3 8.3 0.1 2.8 2 1 1 3 3 3 0 ATP-utilising chromatin assembly and remodelling N-terminal SGS PF05002.15 ETO16161.1 - 0.55 10.4 4.2 0.36 11.0 0.9 2.1 2 0 0 2 2 2 0 SGS domain Pkinase PF00069.25 ETO16162.1 - 1.7e-24 86.6 0.0 2e-24 86.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16162.1 - 4.8e-11 42.4 0.0 6e-11 42.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO16163.1 - 1.4e-09 37.7 0.0 1.8e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 ETO16164.1 - 2.4e-19 69.2 0.0 3.9e-19 68.5 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF547 PF04784.14 ETO16166.1 - 2e-05 24.6 0.1 5.3e-05 23.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Metallothio_11 PF02066.15 ETO16166.1 - 0.19 11.9 5.3 8.9 6.6 1.9 2.6 2 0 0 2 2 2 0 Metallothionein family 11 PBP1_TM PF14812.6 ETO16166.1 - 1.6 9.2 12.3 1.7 9.1 7.0 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal LRR_6 PF13516.6 ETO16167.1 - 3.4e-23 79.7 11.9 0.018 15.1 0.1 8.3 8 0 0 8 8 8 7 Leucine Rich repeat LRR_1 PF00560.33 ETO16167.1 - 8.8e-07 28.6 8.8 16 6.5 0.1 7.4 8 1 0 8 8 8 3 Leucine Rich Repeat LRR_8 PF13855.6 ETO16167.1 - 2.4e-05 24.0 9.5 1.2 9.0 1.1 5.2 4 2 0 4 4 4 4 Leucine rich repeat SDA1 PF05285.12 ETO16167.1 - 0.074 12.5 14.1 0.11 12.0 14.1 1.2 1 0 0 1 1 1 0 SDA1 Menin PF05053.13 ETO16167.1 - 7.2 4.8 10.3 9.1 4.5 10.3 1.1 1 0 0 1 1 1 0 Menin AAA PF00004.29 ETO16168.1 - 3e-41 140.9 0.0 6.6e-41 139.8 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO16168.1 - 1.6e-06 27.8 0.1 3.2e-06 26.8 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ETO16168.1 - 3.3e-05 23.9 0.1 0.00014 21.8 0.0 2.2 2 1 0 2 2 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO16168.1 - 7.6e-05 23.2 0.0 0.019 15.3 0.0 2.4 2 0 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ETO16168.1 - 0.00022 21.0 0.0 0.00076 19.3 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ETO16168.1 - 0.0021 17.3 0.0 0.0039 16.4 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_2 PF07724.14 ETO16168.1 - 0.0024 18.0 0.0 0.014 15.5 0.0 2.3 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO16168.1 - 0.0035 17.6 0.6 0.18 12.0 0.2 2.7 2 1 0 2 2 1 1 AAA domain Sigma54_activat PF00158.26 ETO16168.1 - 0.0043 16.8 0.2 0.13 12.0 0.0 2.9 3 1 0 3 3 3 1 Sigma-54 interaction domain IstB_IS21 PF01695.17 ETO16168.1 - 0.013 15.3 0.0 0.026 14.2 0.0 1.6 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO16168.1 - 0.023 14.1 0.3 0.05 13.0 0.3 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ETO16168.1 - 0.026 15.1 0.0 0.026 15.1 0.0 3.3 3 2 0 3 3 2 0 AAA domain Clathrin_bdg PF15045.6 ETO16168.1 - 0.031 14.3 1.2 0.087 12.8 0.6 2.1 1 1 0 1 1 1 0 Clathrin-binding box of Aftiphilin, vesicle trafficking AAA_33 PF13671.6 ETO16168.1 - 0.037 14.2 0.1 0.1 12.7 0.1 1.9 1 1 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO16168.1 - 0.066 13.2 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 ETO16168.1 - 0.068 12.5 0.1 0.31 10.3 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.6 ETO16168.1 - 0.07 13.4 0.0 0.16 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ETO16168.1 - 0.094 12.8 0.0 0.4 10.8 0.0 2.1 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 ETO16168.1 - 0.099 12.2 0.2 0.37 10.3 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 ETO16168.1 - 1.2 8.9 12.0 1.8 8.3 0.0 3.0 3 0 0 3 3 3 0 AAA domain Paramyxo_ncap PF00973.19 ETO16168.1 - 4.5 6.1 9.7 7.9 5.3 9.7 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein HEAT PF02985.22 ETO16169.1 - 0.00043 20.3 4.6 0.74 10.2 0.0 4.8 4 0 0 4 4 4 2 HEAT repeat Methyltransf_12 PF08242.12 ETO16169.1 - 0.85 10.4 4.7 6.4 7.6 1.8 3.0 3 0 0 3 3 3 0 Methyltransferase domain Secretin_N_2 PF07655.13 ETO16169.1 - 3.6 8.2 15.5 0.028 14.9 6.7 2.0 3 0 0 3 3 3 0 Secretin N-terminal domain HEAT_EZ PF13513.6 ETO16170.1 - 0.0019 18.7 1.5 0.37 11.3 0.1 3.0 3 0 0 3 3 3 1 HEAT-like repeat SUR7 PF06687.12 ETO16170.1 - 0.094 12.3 6.4 0.21 11.2 0.4 2.5 2 0 0 2 2 2 0 SUR7/PalI family Vac14_Fab1_bd PF12755.7 ETO16170.1 - 0.1 13.2 2.4 1.2 9.8 0.1 3.5 2 2 2 4 4 4 0 Vacuolar 14 Fab1-binding region Ribosomal_60s PF00428.19 ETO16170.1 - 3.4 8.3 6.3 8 7.1 6.3 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein Endotoxin_C PF03944.14 ETO16170.1 - 3.9 7.8 8.5 25 5.2 8.6 2.0 1 1 0 1 1 1 0 delta endotoxin FAM176 PF14851.6 ETO16170.1 - 5.1 6.7 7.2 1.6 8.4 2.0 2.3 2 0 0 2 2 2 0 FAM176 family DUF3682 PF12446.8 ETO16170.1 - 7.7 7.0 6.9 14 6.2 6.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) WD40 PF00400.32 ETO16171.1 - 3.3e-63 208.1 17.0 2.6e-09 37.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16171.1 - 5.4e-16 58.7 2.9 0.042 14.2 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16171.1 - 1e-10 41.5 2.1 0.0012 18.2 0.0 3.5 2 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO16171.1 - 2.7e-07 29.6 3.3 2.1 6.9 0.0 5.9 2 1 2 6 6 6 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO16171.1 - 9.1e-05 22.5 1.5 8.9 6.4 0.0 4.7 2 1 2 5 5 5 2 Family of unknown function (DUF5570) DUF5046 PF16465.5 ETO16171.1 - 0.00047 19.7 0.1 3.9 6.8 0.0 3.1 2 1 1 3 3 3 1 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 ETO16171.1 - 0.003 16.1 0.6 2.2 6.7 0.1 2.7 1 1 0 2 2 2 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO16171.1 - 0.0036 16.3 1.9 5.9 5.7 0.0 4.0 2 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO16171.1 - 0.0053 16.1 1.7 13 5.0 0.1 4.5 2 1 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal nos_propeller PF18764.1 ETO16171.1 - 0.018 15.0 0.0 81 3.2 0.0 4.2 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat PD40 PF07676.12 ETO16171.1 - 0.034 14.1 4.3 6.4 6.9 0.1 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF727 PF05303.12 ETO16171.1 - 0.1 12.7 0.9 12 6.0 0.0 3.7 4 1 1 5 5 5 0 Protein of unknown function (DUF727) Nucleoporin_N PF08801.11 ETO16171.1 - 0.14 10.9 7.8 2.4 6.8 0.2 4.3 2 1 3 5 5 5 0 Nup133 N terminal like G-alpha PF00503.20 ETO16172.1 - 6.5e-18 65.0 0.5 7.2e-18 64.9 0.5 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO16172.1 - 0.0029 17.1 0.0 0.0032 16.9 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETO16173.1 - 3.3e-22 79.1 2.6 4.3e-22 78.8 2.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO16173.1 - 0.0025 18.3 0.8 0.0038 17.7 0.8 1.5 1 1 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 ETO16173.1 - 0.0034 17.5 0.1 0.022 14.9 0.1 2.2 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO16173.1 - 0.004 17.7 0.6 0.026 15.1 0.6 2.2 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ETO16173.1 - 0.0051 16.5 0.2 0.0084 15.8 0.2 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO16173.1 - 0.019 15.3 0.0 0.023 15.1 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Arf PF00025.21 ETO16173.1 - 0.02 14.4 0.0 0.034 13.6 0.0 1.4 1 0 0 1 1 1 0 ADP-ribosylation factor family Mg_chelatase PF01078.21 ETO16173.1 - 0.055 12.9 0.0 0.11 11.8 0.0 1.5 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI SRP54 PF00448.22 ETO16173.1 - 0.099 12.3 0.0 0.13 11.8 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain WD40 PF00400.32 ETO16174.1 - 1.8e-18 66.6 14.6 5.3e-05 23.9 1.2 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16174.1 - 2.1e-05 24.7 1.2 2.4 8.5 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16174.1 - 4.8e-05 22.2 0.4 0.021 13.5 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 SurA_N_2 PF13623.6 ETO16175.1 - 0.058 13.3 0.0 0.061 13.2 0.0 1.1 1 0 0 1 1 1 0 SurA N-terminal domain Phage_GP20 PF06810.11 ETO16176.1 - 0.0062 16.4 7.8 0.011 15.6 7.8 1.4 1 0 0 1 1 1 1 Phage minor structural protein GP20 XRCC4 PF06632.12 ETO16176.1 - 0.0069 15.3 4.9 0.0093 14.9 4.9 1.2 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 Spore_III_AF PF09581.10 ETO16176.1 - 0.039 14.0 5.9 0.047 13.7 5.9 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) Dynein_C PF18199.1 ETO16176.1 - 0.99 8.6 5.9 1.2 8.3 5.9 1.1 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain DUF1616 PF07760.11 ETO16176.1 - 2.2 7.6 5.5 2.9 7.2 5.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1616) ASH PF15780.5 ETO16177.1 - 1.1e-05 25.5 0.8 0.63 10.3 0.0 3.5 3 0 0 3 3 3 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Nup192 PF11894.8 ETO16179.1 - 1.1e-19 69.3 0.1 1.3e-19 69.0 0.1 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 NST1 PF13945.6 ETO16180.1 - 0.22 11.6 21.3 0.26 11.4 21.3 1.0 1 0 0 1 1 1 0 Salt tolerance down-regulator MCM_bind PF09739.9 ETO16180.1 - 1.9 6.8 14.8 2.1 6.7 14.8 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ins_P5_2-kin PF06090.12 ETO16181.1 - 0.032 13.7 0.0 0.052 13.0 0.0 1.3 1 1 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase Cytochrome_B PF00033.19 ETO16181.1 - 0.081 12.7 0.2 0.16 11.8 0.2 1.4 1 1 0 1 1 1 0 Cytochrome b/b6/petB Exo84_C PF16528.5 ETO16184.1 - 2.2e-16 60.3 3.3 7.4e-11 42.2 0.3 3.4 3 1 0 3 3 3 2 Exocyst component 84 C-terminal Tir_receptor_C PF07489.11 ETO16184.1 - 1.5 8.8 12.6 0.28 11.1 7.9 2.1 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus SSP160 PF06933.11 ETO16184.1 - 1.6 6.9 17.1 3.5 5.7 17.1 1.5 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 YMF19 PF02326.15 ETO16185.1 - 0.066 14.0 1.6 0.066 14.0 1.6 2.5 2 1 0 2 2 2 0 Plant ATP synthase F0 DUF3438 PF11920.8 ETO16185.1 - 0.36 10.1 3.7 1.9 7.7 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3438) Hep_59 PF07052.11 ETO16185.1 - 2.2 9.1 15.8 0.54 11.0 6.0 2.2 2 0 0 2 2 2 0 Hepatocellular carcinoma-associated antigen 59 FAM76 PF16046.5 ETO16185.1 - 2.7 7.2 13.1 0.66 9.3 0.6 2.1 2 0 0 2 2 2 0 FAM76 protein FAM60A PF15396.6 ETO16185.1 - 6.6 6.7 12.3 1.7 8.6 2.4 2.1 2 0 0 2 2 2 0 Protein Family FAM60A UAA PF08449.11 ETO16186.1 - 1.3e-22 80.4 11.9 1.6e-22 80.1 11.9 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO16186.1 - 0.0003 21.0 13.6 0.0074 16.5 13.3 2.2 1 1 2 3 3 3 2 EamA-like transporter family DUF981 PF06168.11 ETO16186.1 - 0.00064 19.7 0.7 0.0011 19.0 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF981) DUF2070 PF09843.9 ETO16186.1 - 0.35 9.1 8.0 0.42 8.8 8.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) PRA-CH PF01502.18 ETO16187.1 - 0.016 15.0 0.0 0.022 14.6 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl-AMP cyclohydrolase ATG16 PF08614.11 ETO16188.1 - 0.01 16.1 1.9 0.01 16.1 1.9 5.5 3 1 2 5 5 5 1 Autophagy protein 16 (ATG16) DinB_2 PF12867.7 ETO16188.1 - 0.023 15.2 0.2 0.13 12.8 0.2 2.3 1 1 0 1 1 1 0 DinB superfamily DUF948 PF06103.11 ETO16188.1 - 0.16 12.3 11.1 3.6 7.9 0.0 4.3 2 2 2 4 4 4 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 ETO16188.1 - 0.45 10.1 45.2 1.2 8.6 35.0 3.2 1 1 2 3 3 3 0 Intermediate filament protein CENP-F_leu_zip PF10473.9 ETO16188.1 - 1.2 9.2 47.8 1.1 9.2 18.8 4.9 1 1 3 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 ETO16188.1 - 4.1 7.7 40.6 2.2 8.5 5.7 5.0 2 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding DUF4407 PF14362.6 ETO16188.1 - 7.4 5.8 30.9 6.9 5.9 8.2 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4065 PF13274.6 ETO16190.1 - 0.13 13.1 6.9 2 9.3 6.9 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF4065) DUF1319 PF07028.11 ETO16190.1 - 5.6 7.2 13.1 3.3 8.0 0.3 2.8 2 1 0 3 3 3 0 Protein of unknown function (DUF1319) RimK PF08443.11 ETO16191.1 - 1.4e-30 106.4 0.2 5.2e-27 94.7 0.0 3.1 1 1 1 2 2 2 2 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ETO16191.1 - 1.1e-07 31.4 0.0 2.7e-07 30.2 0.0 1.6 1 1 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain Rimk_N PF18030.1 ETO16191.1 - 0.0016 18.8 0.0 0.25 11.8 0.0 2.6 1 1 0 1 1 1 1 RimK PreATP-grasp domain ATP-grasp_3 PF02655.14 ETO16191.1 - 0.026 14.6 0.6 1.6 8.8 0.0 2.4 2 0 0 2 2 2 0 ATP-grasp domain ATP-synt_E PF05680.12 ETO16191.1 - 0.78 10.1 5.1 0.43 10.9 0.2 2.6 3 0 0 3 3 3 0 ATP synthase E chain SAM_2 PF07647.17 ETO16196.1 - 0.0067 16.5 0.5 2.2 8.4 0.0 3.9 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO16196.1 - 0.022 15.2 0.8 3.6 8.1 0.0 3.5 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) PriC PF07445.12 ETO16196.1 - 0.025 14.5 5.5 1.3 8.9 1.9 2.4 2 0 0 2 2 2 0 Primosomal replication protein priC DUF4291 PF14124.6 ETO16196.1 - 0.14 12.0 1.9 0.24 11.2 1.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4291) Dynein_C PF18199.1 ETO16196.1 - 0.58 9.3 5.0 0.93 8.6 5.0 1.2 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain Phage_GP20 PF06810.11 ETO16196.1 - 1.2 8.9 18.5 0.33 10.7 13.1 2.6 2 2 0 2 2 2 0 Phage minor structural protein GP20 MttA_Hcf106 PF02416.16 ETO16196.1 - 2 7.8 6.5 9.9 5.6 3.5 2.5 2 1 0 2 2 2 0 mttA/Hcf106 family CC2-LZ PF16516.5 ETO16197.1 - 0.0057 17.0 7.5 0.01 16.2 7.3 1.6 1 1 0 1 1 1 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator FAM76 PF16046.5 ETO16197.1 - 0.016 14.6 5.7 0.019 14.3 5.7 1.3 1 0 0 1 1 1 0 FAM76 protein FlxA PF14282.6 ETO16197.1 - 0.047 13.7 13.8 0.091 12.8 13.8 1.5 1 0 0 1 1 1 0 FlxA-like protein XLF PF09302.11 ETO16197.1 - 0.5 10.5 9.1 0.16 12.1 3.5 2.0 1 1 1 2 2 2 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DUF3450 PF11932.8 ETO16197.1 - 0.58 9.4 9.5 0.87 8.8 9.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) V-ATPase_H_C PF11698.8 ETO16197.1 - 1.7 8.8 7.7 0.7 10.0 4.1 1.9 1 1 1 2 2 2 0 V-ATPase subunit H UPF0242 PF06785.11 ETO16197.1 - 6.1 6.9 13.1 5.5 7.1 12.4 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Hamartin PF04388.12 ETO16200.1 - 7 5.2 39.6 8.9 4.8 39.6 1.1 1 0 0 1 1 1 0 Hamartin protein IBR PF01485.21 ETO16201.1 - 9.5e-09 35.4 27.7 0.00019 21.6 9.1 3.5 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ETO16201.1 - 1.2e-05 25.1 7.8 1.2e-05 25.1 7.8 4.2 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO16201.1 - 7.3e-05 22.7 9.6 7.3e-05 22.7 9.6 4.5 3 3 0 3 3 3 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETO16201.1 - 0.00012 21.8 4.7 0.00012 21.8 4.7 4.4 4 1 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO16201.1 - 0.00012 22.0 5.3 0.00012 22.0 5.3 3.2 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETO16201.1 - 0.00051 20.1 1.9 0.00051 20.1 1.9 4.5 4 1 0 4 4 4 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ETO16201.1 - 0.00068 19.9 6.7 0.00068 19.9 6.7 4.2 2 2 1 3 3 3 1 Ring finger domain Prok-RING_4 PF14447.6 ETO16201.1 - 0.0017 18.2 3.0 0.0017 18.2 3.0 4.1 4 1 0 4 4 4 1 Prokaryotic RING finger family 4 PRP21_like_P PF12230.8 ETO16201.1 - 0.082 12.8 0.3 0.13 12.1 0.3 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein ER PF01133.17 ETO16201.1 - 0.096 12.7 0.2 0.2 11.7 0.2 1.5 1 0 0 1 1 1 0 Enhancer of rudimentary Arm-DNA-bind_2 PF12167.8 ETO16203.1 - 0.1 12.5 0.9 0.34 10.9 0.9 1.9 1 0 0 1 1 1 0 Arm DNA-binding domain FliD_N PF02465.18 ETO16203.1 - 5.4 7.8 14.0 0.59 10.9 5.1 2.7 1 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Thioredoxin_6 PF13848.6 ETO16204.1 - 1.1e-07 32.0 3.7 0.00092 19.2 0.5 3.6 3 1 0 3 3 3 2 Thioredoxin-like domain NKAIN PF05640.14 ETO16204.1 - 0.047 12.9 0.0 0.21 10.8 0.0 1.9 2 0 0 2 2 2 0 Na,K-Atpase Interacting protein DUF5400 PF17379.2 ETO16205.1 - 0.025 15.0 0.7 0.041 14.3 0.7 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5400) PKD_2 PF16407.5 ETO16205.1 - 0.086 13.0 0.0 0.11 12.6 0.0 1.2 1 0 0 1 1 1 0 PKD-like family Utp12 PF04003.12 ETO16206.1 - 0.073 13.4 2.8 0.19 12.1 0.1 2.7 3 1 0 3 3 3 0 Dip2/Utp12 Family CRAL_TRIO PF00650.20 ETO16207.1 - 0.072 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 CRAL/TRIO domain Metallophos PF00149.28 ETO16207.1 - 0.097 13.2 0.1 0.14 12.7 0.1 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase WD40 PF00400.32 ETO16208.1 - 6.3e-60 197.7 23.2 2.8e-10 40.6 0.3 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16208.1 - 6.6e-21 74.4 2.6 0.014 15.7 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16208.1 - 1.6e-17 63.5 7.9 0.00029 19.9 0.9 6.2 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16208.1 - 3e-13 50.1 0.2 5.3e-05 23.2 0.0 3.7 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO16208.1 - 2.5e-08 32.9 1.3 0.0016 17.0 0.1 3.4 2 1 0 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO16208.1 - 6e-08 32.4 9.6 0.00062 19.2 0.0 4.4 2 1 3 5 5 5 2 WD40-like domain Nbas_N PF15492.6 ETO16208.1 - 0.00011 21.7 4.0 0.85 8.9 0.1 4.5 1 1 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO16208.1 - 0.00037 20.4 7.7 7.1 6.7 0.0 5.7 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO16208.1 - 0.06 13.5 0.0 4.2 7.6 0.0 3.6 1 1 2 3 3 3 0 Strictosidine synthase Proteasome_A_N PF10584.9 ETO16208.1 - 0.74 9.6 5.9 68 3.3 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature zf-CCHC PF00098.23 ETO16209.1 - 0.0078 16.2 29.4 0.082 13.0 7.1 3.4 3 0 0 3 3 3 3 Zinc knuckle BNIP2 PF12496.8 ETO16209.1 - 0.074 13.5 2.3 0.12 12.8 2.2 1.4 1 1 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 zf-CCHC_4 PF14392.6 ETO16209.1 - 3.2 7.6 23.0 1.4 8.7 3.9 3.3 2 1 1 3 3 3 0 Zinc knuckle DUF2777 PF10949.8 ETO16210.1 - 0.011 15.5 1.0 0.012 15.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2777) DUF1707 PF08044.11 ETO16210.1 - 0.013 15.5 0.0 0.03 14.4 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1707) GvpG PF05120.12 ETO16210.1 - 0.022 14.8 0.8 0.026 14.5 0.1 1.6 2 0 0 2 2 2 0 Gas vesicle protein G SRI PF08236.11 ETO16210.1 - 0.044 14.0 0.7 0.079 13.1 0.7 1.4 1 1 0 1 1 1 0 SRI (Set2 Rpb1 interacting) domain Apt1 PF10351.9 ETO16211.1 - 0.0046 15.9 8.9 0.0059 15.5 8.9 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Nop14 PF04147.12 ETO16211.1 - 0.11 10.7 30.5 0.14 10.3 30.5 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO16211.1 - 0.97 8.8 35.7 1.3 8.4 35.7 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO16211.1 - 1.9 6.7 26.2 2.6 6.2 26.2 1.2 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO16211.1 - 3.2 8.2 6.7 6.4 7.2 6.6 1.5 1 1 0 1 1 1 0 RNA polymerase III RPC4 NPR3 PF03666.13 ETO16211.1 - 3.9 6.2 7.5 5 5.8 7.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RRN3 PF05327.11 ETO16211.1 - 7.5 5.0 24.7 11 4.4 24.7 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 LRR_6 PF13516.6 ETO16212.1 - 0.0066 16.4 5.6 1.2 9.4 0.1 4.3 4 1 0 4 4 4 2 Leucine Rich repeat LRR_8 PF13855.6 ETO16212.1 - 0.096 12.5 2.9 7.5 6.4 0.4 3.0 3 1 0 3 3 3 0 Leucine rich repeat CCDC71L PF15374.6 ETO16214.1 - 0.055 12.7 4.2 0.062 12.6 4.2 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L Nucleoside_tran PF01733.18 ETO16214.1 - 0.056 12.8 0.7 0.066 12.6 0.7 1.2 1 0 0 1 1 1 0 Nucleoside transporter RR_TM4-6 PF06459.12 ETO16214.1 - 0.45 10.3 11.7 0.88 9.3 11.4 1.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 HBB PF06777.11 ETO16215.1 - 4.2e-21 75.5 5.0 1.6e-17 63.8 3.2 3.9 2 1 0 2 2 2 1 Helical and beta-bridge domain DEAD_2 PF06733.15 ETO16215.1 - 3.9e-10 39.6 0.3 8e-10 38.6 0.3 1.5 1 0 0 1 1 1 1 DEAD_2 DUF1722 PF08349.11 ETO16215.1 - 0.012 15.8 3.2 0.37 11.1 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) SF3A3 PF16837.5 ETO16215.1 - 0.014 15.9 0.1 0.12 13.0 0.1 2.3 1 1 0 1 1 1 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 Meis_PKNOX_N PF16493.5 ETO16215.1 - 0.037 14.3 0.3 1.6 9.1 0.0 2.6 2 0 0 2 2 2 0 N-terminal of Homeobox Meis and PKNOX1 Muted PF14942.6 ETO16215.1 - 0.084 13.2 1.7 6.4 7.1 0.3 2.3 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein DUF496 PF04363.12 ETO16215.1 - 0.12 12.5 2.5 0.27 11.3 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF496) Helicase_C_2 PF13307.6 ETO16216.1 - 2.7e-38 131.8 0.8 2.8e-19 69.9 0.1 2.3 2 0 0 2 2 2 2 Helicase C-terminal domain DUF1788 PF08747.11 ETO16217.1 - 0.67 10.0 4.3 0.98 9.4 0.4 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1788) RP-C_C PF11800.8 ETO16217.1 - 1.6 8.7 5.0 0.3 11.1 1.7 1.6 2 0 0 2 2 2 0 Replication protein C C-terminal region SAM_2 PF07647.17 ETO16218.1 - 0.017 15.2 0.9 20 5.4 0.0 4.3 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) DUF4154 PF13689.6 ETO16218.1 - 0.034 14.4 0.0 0.11 12.7 0.0 1.8 1 0 0 1 1 1 0 YfiR/HmsC-like CobT PF06213.12 ETO16218.1 - 0.21 11.0 4.6 0.38 10.1 4.6 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 ETO16218.1 - 9.5 5.9 10.3 1 9.0 5.1 2.1 2 0 0 2 2 2 0 FAM176 family EF-hand_1 PF00036.32 ETO16219.1 - 5.5e-21 72.5 5.2 0.00025 20.3 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO16219.1 - 2.3e-18 66.4 5.6 1.2e-08 35.3 1.8 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO16219.1 - 4.9e-17 60.3 7.2 0.0017 18.1 0.1 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO16219.1 - 1.8e-10 39.8 2.3 0.0036 16.7 0.3 4.9 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO16219.1 - 1.4e-09 37.7 11.3 0.011 15.6 0.3 5.3 2 1 3 5 5 5 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO16219.1 - 5.9e-05 23.0 2.4 0.099 12.6 0.1 3.4 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ETO16219.1 - 6.7e-05 23.1 0.0 0.23 11.8 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO16219.1 - 0.029 14.7 12.2 0.049 13.9 0.2 3.4 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 ETO16219.1 - 0.049 14.0 0.7 2.3 8.6 0.1 3.3 2 1 0 2 2 2 0 EF-hand domain PRP9_N PF16958.5 ETO16219.1 - 0.38 10.8 4.6 12 5.9 0.4 3.0 3 0 0 3 3 3 0 Pre-mRNA-splicing factor PRP9 N-terminus TPR_17 PF13431.6 ETO16220.1 - 5.2e-05 23.4 10.7 0.022 15.1 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO16220.1 - 0.0018 18.9 0.5 0.042 14.7 0.1 2.8 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO16220.1 - 0.0039 17.7 8.6 0.027 15.0 3.3 2.8 3 1 1 4 4 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO16220.1 - 0.0039 17.3 6.2 0.21 11.9 0.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO16220.1 - 0.005 17.1 4.5 0.11 12.9 0.7 3.1 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO16220.1 - 0.0084 16.2 0.3 0.0084 16.2 0.3 3.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16220.1 - 0.015 15.1 5.5 0.38 10.7 0.3 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat NRDE-2 PF08424.10 ETO16220.1 - 0.019 14.1 0.9 0.025 13.7 0.9 1.2 1 0 0 1 1 1 0 NRDE-2, necessary for RNA interference DUF3408 PF11888.8 ETO16220.1 - 0.023 14.9 3.1 0.58 10.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) TPR_11 PF13414.6 ETO16220.1 - 0.032 13.9 0.3 0.032 13.9 0.3 2.8 2 1 1 3 3 3 0 TPR repeat TPR_16 PF13432.6 ETO16220.1 - 0.036 14.7 0.6 0.075 13.7 0.6 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO16220.1 - 0.054 13.7 9.7 0.07 13.4 5.4 2.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ETO16220.1 - 0.45 10.5 1.8 3.7 7.6 0.3 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO16220.1 - 0.66 10.1 3.7 12 6.2 0.2 3.2 3 1 0 4 4 4 0 Tetratricopeptide repeat DUF480 PF04337.12 ETO16221.1 - 0.047 13.8 2.3 2.2 8.3 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function, DUF480 Arf PF00025.21 ETO16222.1 - 1.2e-11 44.4 0.0 0.00051 19.5 0.0 3.9 3 1 0 3 3 3 3 ADP-ribosylation factor family Neur_chan_memb PF02932.16 ETO16224.1 - 4.2 7.4 7.0 5.1 7.1 7.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Raftlin PF15250.6 ETO16224.1 - 8.8 5.0 12.3 10 4.7 12.3 1.1 1 0 0 1 1 1 0 Raftlin TMEM215 PF15746.5 ETO16224.1 - 10 5.5 7.9 0.61 9.5 1.8 1.7 1 1 0 1 1 1 0 TMEM215 family Hydin_ADK PF17213.3 ETO16225.1 - 0.74 10.1 4.4 0.88 9.8 4.4 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain SLC12 PF03522.15 ETO16225.1 - 1.1 8.2 12.4 1.2 8.1 12.4 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 ETO16225.1 - 1.8 8.4 16.0 0.84 9.4 14.1 1.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TMEM237 PF15383.6 ETO16225.1 - 3.5 6.7 6.5 4.7 6.2 6.5 1.1 1 0 0 1 1 1 0 Transmembrane protein 237 DUF4079 PF13301.6 ETO16225.1 - 3.8 7.7 4.3 49 4.0 4.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) CLN3 PF02487.17 ETO16225.1 - 4.3 6.3 7.3 5.3 6.0 7.3 1.1 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 ETO16225.1 - 4.7 5.9 13.1 5.6 5.6 13.1 1.1 1 0 0 1 1 1 0 Presenilin Phage_capsid PF05065.13 ETO16226.1 - 1.7e-48 165.3 0.1 2.2e-48 165.0 0.1 1.1 1 0 0 1 1 1 1 Phage capsid family PRP21_like_P PF12230.8 ETO16226.1 - 0.00033 20.6 1.7 0.00045 20.2 1.7 1.2 1 0 0 1 1 1 1 Pre-mRNA splicing factor PRP21 like protein Lac_bphage_repr PF06543.12 ETO16226.1 - 0.033 14.2 0.1 0.078 13.0 0.1 1.6 1 0 0 1 1 1 0 Lactococcus bacteriophage repressor Phage_tail_APC PF16778.5 ETO16226.1 - 0.12 12.3 0.0 0.33 10.9 0.0 1.8 2 0 0 2 2 2 0 Phage tail assembly chaperone protein Peptidase_S78 PF04586.17 ETO16227.1 - 3.4e-26 92.4 0.0 4.3e-26 92.0 0.0 1.2 1 0 0 1 1 1 1 Caudovirus prohead serine protease Phage_portal PF04860.12 ETO16228.1 - 1.1e-70 238.4 0.0 1.2e-70 238.2 0.0 1.0 1 0 0 1 1 1 1 Phage portal protein Phage_portal_2 PF05136.13 ETO16229.1 - 0.34 10.0 3.0 0.47 9.6 3.0 1.1 1 0 0 1 1 1 0 Phage portal protein, lambda family Zip PF02535.22 ETO16229.1 - 0.99 8.6 2.5 1 8.5 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO16229.1 - 6.1 5.5 5.8 6.6 5.4 5.8 1.2 1 0 0 1 1 1 0 Presenilin zf-RING_5 PF14634.6 ETO16230.1 - 3.2e-06 27.0 9.2 1.1e-05 25.3 9.3 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO16230.1 - 1.8e-05 24.7 5.4 4.7e-05 23.3 5.4 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO16230.1 - 1.8e-05 24.5 7.5 1.8e-05 24.5 7.5 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO16230.1 - 3.2e-05 23.7 6.2 3.2e-05 23.7 6.2 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO16230.1 - 7.9e-05 22.9 6.2 0.00018 21.8 6.2 1.7 1 0 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ETO16230.1 - 0.001 18.9 5.3 0.0029 17.4 5.3 1.8 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ETO16230.1 - 0.0056 16.8 9.6 0.0062 16.7 6.7 2.5 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING eIF3g PF12353.8 ETO16230.1 - 0.03 14.7 0.2 0.062 13.7 0.0 1.5 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G FlbT PF07378.11 ETO16230.1 - 0.033 14.2 0.0 0.048 13.7 0.0 1.2 1 0 0 1 1 1 0 Flagellar protein FlbT zf-RING_11 PF17123.5 ETO16230.1 - 2.8 7.8 11.1 8.4 6.2 11.1 1.8 1 0 0 1 1 1 0 RING-like zinc finger DENN PF02141.21 ETO16231.1 - 4.9e-50 170.1 2.6 4.9e-50 170.1 2.6 2.2 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 ETO16231.1 - 1e-11 45.4 0.1 3.5e-11 43.7 0.1 2.0 1 0 0 1 1 1 1 uDENN domain dDENN PF03455.19 ETO16231.1 - 1.3e-10 41.1 1.3 1.3e-10 41.1 1.3 2.7 3 0 0 3 3 3 1 dDENN domain MMR_HSR1 PF01926.23 ETO16232.1 - 0.00017 21.6 0.2 0.0019 18.3 0.2 3.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO16232.1 - 0.00056 20.4 0.1 0.00056 20.4 0.1 4.4 4 1 0 4 4 4 1 ABC transporter RsgA_GTPase PF03193.16 ETO16232.1 - 0.00088 19.2 3.3 0.0027 17.7 0.1 3.4 2 1 0 2 2 2 1 RsgA GTPase AAA_29 PF13555.6 ETO16232.1 - 0.0057 16.4 0.1 0.031 14.0 0.1 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain T2SSE PF00437.20 ETO16232.1 - 0.0076 15.3 0.0 0.023 13.7 0.0 1.8 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 ETO16232.1 - 0.025 14.9 4.8 0.027 14.8 0.0 3.1 3 1 0 3 3 3 0 AAA domain PhoH PF02562.16 ETO16232.1 - 0.037 13.5 0.8 0.15 11.5 0.1 2.4 2 0 0 2 2 2 0 PhoH-like protein AAA_33 PF13671.6 ETO16232.1 - 0.043 14.0 6.8 2.1 8.5 0.0 3.7 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 ETO16232.1 - 0.29 11.6 0.1 0.29 11.6 0.1 7.1 3 1 0 3 3 2 0 AAA domain Mating_N PF12731.7 ETO16232.1 - 0.76 9.9 3.6 1.5 8.9 0.3 3.2 4 0 0 4 4 4 0 Mating-type protein beta 1 AAA_22 PF13401.6 ETO16232.1 - 0.78 10.0 3.3 4.8 7.5 0.0 3.9 3 1 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO16232.1 - 1.9 7.8 4.6 0.79 9.0 0.1 2.6 3 1 1 4 4 4 0 FtsK/SpoIIIE family ApoC-I PF04691.12 ETO16232.1 - 4.7 7.2 10.7 4.1 7.4 3.0 4.5 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) Nop14 PF04147.12 ETO16233.1 - 0.0063 14.8 34.6 0.0079 14.5 34.6 1.2 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.10 ETO16233.1 - 0.017 14.5 31.8 0.024 14.0 31.8 1.1 1 0 0 1 1 1 0 BUD22 Hid1 PF12722.7 ETO16233.1 - 0.79 7.8 15.4 1.1 7.4 15.4 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF913 PF06025.12 ETO16233.1 - 6.3 5.7 28.3 1.3e+03 -1.9 28.3 2.3 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) TB2_DP1_HVA22 PF03134.19 ETO16234.1 - 0.022 14.7 0.1 0.022 14.7 0.1 1.9 2 0 0 2 2 2 0 TB2/DP1, HVA22 family Reprolysin_3 PF13582.6 ETO16235.1 - 0.12 12.9 6.2 0.73 10.4 0.3 2.3 2 1 0 2 2 2 0 Metallo-peptidase family M12B Reprolysin-like LMBR1 PF04791.16 ETO16235.1 - 3.7 6.3 10.5 4.5 6.1 10.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein FapA PF03961.13 ETO16235.1 - 5.9 5.4 14.7 7.3 5.1 14.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-MYND PF01753.18 ETO16236.1 - 1e-05 25.5 24.2 4.6e-05 23.4 16.1 2.6 2 0 0 2 2 2 2 MYND finger GREB1 PF15782.5 ETO16236.1 - 0.14 9.3 18.0 0.19 8.8 18.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TFIIA PF03153.13 ETO16236.1 - 0.19 11.7 31.5 0.23 11.4 31.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1639 PF07797.14 ETO16236.1 - 1.1 9.3 6.5 0.91 9.5 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) Menin PF05053.13 ETO16236.1 - 3 6.1 7.8 3.9 5.7 7.8 1.1 1 0 0 1 1 1 0 Menin SOG2 PF10428.9 ETO16236.1 - 3.2 6.9 23.7 3.8 6.6 23.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein OmpH PF03938.14 ETO16236.1 - 4.4 7.6 19.4 7.6 6.9 19.4 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Lin-8 PF03353.15 ETO16236.1 - 4.8 6.7 18.6 7.4 6.0 18.6 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SAM_1 PF00536.30 ETO16238.1 - 2.2e-10 40.8 0.0 4.4e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO16238.1 - 1.3e-08 34.8 0.0 2.7e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO16238.1 - 0.00019 21.3 0.0 0.00047 20.1 0.0 1.7 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Thyroglob_assoc PF16597.5 ETO16238.1 - 0.0057 16.9 1.0 0.025 14.9 1.0 2.2 1 0 0 1 1 1 1 Thyroglobulin_1 repeat associated disordered domain PUFD PF16553.5 ETO16238.1 - 5 7.3 7.5 0.56 10.3 0.9 2.7 1 1 2 3 3 3 0 BCORL-PCGF1-binding domain RasGEF PF00617.19 ETO16239.1 - 4.9e-31 108.3 5.5 9.9e-18 64.9 0.1 3.1 3 1 1 4 4 4 2 RasGEF domain RasGEF_N PF00618.20 ETO16239.1 - 3.7e-10 40.0 0.1 3.7e-10 40.0 0.1 2.6 3 0 0 3 3 3 1 RasGEF N-terminal motif PMC2NT PF08066.12 ETO16239.1 - 0.48 11.2 3.3 0.42 11.3 0.4 2.5 2 0 0 2 2 2 0 PMC2NT (NUC016) domain MAS20 PF02064.15 ETO16239.1 - 2.5 8.2 12.7 0.12 12.5 0.6 2.6 2 0 0 2 2 2 0 MAS20 protein import receptor DUF4790 PF16037.5 ETO16239.1 - 8.8 6.9 9.4 1.1 9.7 3.5 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4790) UCH PF00443.29 ETO16240.1 - 3.6e-30 105.3 1.6 7.3e-30 104.3 1.6 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO16240.1 - 1.5e-17 64.2 3.2 1.5e-17 64.2 3.2 2.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF1492 PF07374.11 ETO16240.1 - 0.14 12.4 0.2 0.95 9.7 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1492) zf-Sec23_Sec24 PF04810.15 ETO16240.1 - 9.4 6.4 9.4 6.7 6.9 1.3 2.9 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger WD40 PF00400.32 ETO16242.1 - 4.3e-11 43.2 5.5 4.4e-07 30.5 0.2 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16242.1 - 7e-05 23.0 0.1 0.001 19.3 0.1 2.1 1 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO16242.1 - 0.11 11.2 0.2 0.49 9.1 0.2 1.8 1 1 0 1 1 1 0 Nup133 N terminal like Beach PF02138.18 ETO16243.1 - 1e-59 202.2 0.2 1.2e-59 202.0 0.2 1.0 1 0 0 1 1 1 1 Beige/BEACH domain HEAT PF02985.22 ETO16244.1 - 0.0088 16.2 9.2 13 6.4 0.0 6.0 6 0 0 6 6 6 2 HEAT repeat DUF1430 PF07242.11 ETO16244.1 - 0.026 14.8 0.9 0.026 14.8 0.9 3.1 4 0 0 4 4 4 0 Protein of unknown function (DUF1430) DUF2304 PF10066.9 ETO16244.1 - 4.8 7.4 8.8 0.16 12.2 0.7 2.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) HH_signal PF01085.18 ETO16245.1 - 0.0016 18.1 0.1 0.0038 16.9 0.1 1.6 1 0 0 1 1 1 1 Hedgehog amino-terminal signalling domain PH PF00169.29 ETO16246.1 - 8.9e-09 35.8 0.4 2.6e-08 34.3 0.1 2.1 2 0 0 2 2 2 1 PH domain PH_2 PF08458.10 ETO16246.1 - 0.0023 18.2 0.1 0.006 16.9 0.1 1.7 1 0 0 1 1 1 1 Plant pleckstrin homology-like region PH_11 PF15413.6 ETO16246.1 - 0.089 13.2 0.1 0.089 13.2 0.1 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain PH_TFIIH PF08567.11 ETO16246.1 - 0.099 13.0 0.8 0.33 11.3 0.1 2.3 2 0 0 2 2 2 0 TFIIH p62 subunit, N-terminal domain DUF2205 PF10224.9 ETO16247.1 - 0.011 15.8 9.0 0.011 15.8 9.0 1.8 1 1 1 2 2 2 0 Short coiled-coil protein NRBF2 PF08961.10 ETO16247.1 - 0.031 13.9 8.8 0.039 13.6 8.8 1.3 1 0 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator Ly49 PF08391.10 ETO16247.1 - 0.11 12.8 13.0 0.062 13.7 11.3 1.4 1 1 0 1 1 1 0 Ly49-like protein, N-terminal region DUF1980 PF09323.10 ETO16247.1 - 0.93 9.4 5.4 0.67 9.8 4.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1980) CSG2 PF16965.5 ETO16247.1 - 5 6.0 5.1 5 6.0 5.1 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Spc7_N PF15402.6 ETO16248.1 - 0.09 11.0 1.0 0.13 10.5 1.0 1.1 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 TMF_DNA_bd PF12329.8 ETO16248.1 - 2 8.5 6.7 0.11 12.6 1.2 1.7 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding TFIID_20kDa PF03847.13 ETO16249.1 - 2.9e-08 34.1 0.0 6e-08 33.1 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor TFIID subunit A CBFD_NFYB_HMF PF00808.23 ETO16249.1 - 0.0015 18.8 0.1 0.0037 17.5 0.0 1.8 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID-31kDa PF02291.15 ETO16249.1 - 0.0027 17.8 0.0 0.0055 16.8 0.0 1.5 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit Bromo_TP PF07524.13 ETO16249.1 - 0.035 14.1 0.0 0.065 13.3 0.0 1.4 1 0 0 1 1 1 0 Bromodomain associated NAD_binding_1 PF00175.21 ETO16250.1 - 2e-22 79.9 0.0 5.1e-21 75.4 0.0 2.4 1 1 0 1 1 1 1 Oxidoreductase NAD-binding domain FAD_binding_6 PF00970.24 ETO16250.1 - 2.6e-17 63.0 0.0 5.2e-17 62.0 0.0 1.5 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_6 PF08030.12 ETO16250.1 - 8.4e-05 22.7 0.0 0.036 14.2 0.0 2.7 2 0 0 2 2 2 2 Ferric reductase NAD binding domain CybS PF05328.12 ETO16251.1 - 0.05 13.3 0.1 0.074 12.7 0.1 1.2 1 0 0 1 1 1 0 CybS, succinate dehydrogenase cytochrome B small subunit DUF4986 PF16375.5 ETO16253.1 - 0.038 14.7 0.1 0.26 12.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function PH PF00169.29 ETO16254.1 - 1.1e-07 32.3 3.5 2.2e-07 31.3 0.8 2.3 2 0 0 2 2 2 1 PH domain PH_4 PF15404.6 ETO16254.1 - 0.02 14.7 1.5 0.02 14.7 1.5 2.0 2 1 0 2 2 2 0 Pleckstrin homology domain PH_6 PF15406.6 ETO16254.1 - 0.023 15.0 0.2 0.065 13.5 0.2 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 ETO16254.1 - 0.064 13.1 0.5 0.16 11.8 0.0 1.9 2 0 0 2 2 2 0 PH domain DUF563 PF04577.14 ETO16256.1 - 2.1e-10 41.1 0.1 5.3e-10 39.8 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF563) RGS PF00615.19 ETO16257.1 - 3.2e-05 24.2 1.1 3.2e-05 24.2 1.1 1.8 2 0 0 2 2 2 1 Regulator of G protein signaling domain Cas_CT1975 PF09344.10 ETO16257.1 - 0.00096 18.7 1.3 0.0012 18.4 0.5 1.5 2 0 0 2 2 2 1 CT1975-like protein EF-hand_7 PF13499.6 ETO16258.1 - 7e-12 45.6 7.2 3.1e-10 40.4 1.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO16258.1 - 4.1e-08 32.2 9.8 0.00076 18.9 0.9 3.3 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO16258.1 - 5.9e-07 29.2 5.7 0.0059 16.4 0.3 3.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO16258.1 - 6e-07 28.7 3.8 0.01 15.3 0.1 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO16258.1 - 8.5e-07 28.4 6.3 0.001 18.8 0.2 3.4 4 0 0 4 4 4 2 EF-hand domain RR_TM4-6 PF06459.12 ETO16258.1 - 0.081 12.7 19.5 0.13 12.1 19.5 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TMEM119 PF15724.5 ETO16258.1 - 0.55 10.3 5.5 1.1 9.3 5.5 1.5 1 0 0 1 1 1 0 TMEM119 family Pinin_SDK_memA PF04696.13 ETO16258.1 - 0.97 9.5 24.4 0.91 9.6 18.9 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region SpoIIIAH PF12685.7 ETO16258.1 - 1.7 8.4 21.7 3.9 7.2 10.3 2.5 2 1 0 2 2 2 0 SpoIIIAH-like protein SOBP PF15279.6 ETO16258.1 - 1.7 9.2 12.0 2.2 8.8 12.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein PDCD2_C PF04194.13 ETO16258.1 - 9.6 6.2 17.6 0.56 10.3 11.6 1.9 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain KLRAQ PF10205.9 ETO16259.1 - 0.0032 17.7 4.9 0.0046 17.2 3.1 2.0 2 0 0 2 2 2 1 Predicted coiled-coil domain-containing protein HAUS6_N PF14661.6 ETO16259.1 - 0.0084 15.7 1.9 1.7 8.2 2.0 2.2 2 0 0 2 2 2 1 HAUS augmin-like complex subunit 6 N-terminus DUF4407 PF14362.6 ETO16259.1 - 0.016 14.6 3.6 0.02 14.2 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SlyX PF04102.12 ETO16259.1 - 0.024 15.3 3.5 0.024 15.3 3.5 2.9 3 1 1 4 4 3 0 SlyX HrpB7 PF09486.10 ETO16259.1 - 0.035 14.5 7.2 0.073 13.5 7.2 1.4 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) KfrA_N PF11740.8 ETO16259.1 - 0.063 14.0 4.0 0.26 12.0 1.9 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Sec8_exocyst PF04048.14 ETO16259.1 - 0.078 12.9 3.7 0.14 12.1 2.2 2.0 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain DSHCT PF08148.12 ETO16259.1 - 0.092 12.4 0.3 0.27 10.9 0.1 1.7 2 0 0 2 2 2 0 DSHCT (NUC185) domain SLT PF01464.20 ETO16259.1 - 0.11 12.1 0.6 0.22 11.2 0.2 1.8 2 0 0 2 2 1 0 Transglycosylase SLT domain DUF1465 PF07323.12 ETO16259.1 - 0.15 11.9 6.6 2.9 7.7 0.2 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1465) Tup_N PF08581.10 ETO16259.1 - 0.15 12.4 13.5 0.29 11.5 8.8 2.9 3 0 0 3 3 3 0 Tup N-terminal LepB_N PF18640.1 ETO16259.1 - 0.19 11.3 2.4 0.12 11.9 0.7 1.7 2 0 0 2 2 1 0 LepB N-terminal domain TMPIT PF07851.13 ETO16259.1 - 0.2 10.9 1.2 0.33 10.1 1.2 1.3 1 0 0 1 1 1 0 TMPIT-like protein Wx5_PLAF3D7 PF09688.10 ETO16259.1 - 0.21 11.6 6.4 3.3 7.7 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) DUF1690 PF07956.11 ETO16259.1 - 0.23 11.9 10.2 7 7.1 0.0 2.3 2 1 0 2 2 2 0 Protein of Unknown function (DUF1690) DUF883 PF05957.13 ETO16259.1 - 0.32 11.6 4.1 0.2 12.3 1.6 2.1 2 0 0 2 2 1 0 Bacterial protein of unknown function (DUF883) Spc7 PF08317.11 ETO16259.1 - 0.34 9.7 9.9 0.12 11.2 7.3 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein EzrA PF06160.12 ETO16259.1 - 0.39 8.8 14.4 0.07 11.3 9.1 2.2 2 1 1 3 3 3 0 Septation ring formation regulator, EzrA T3SSipB PF16535.5 ETO16259.1 - 0.56 10.7 8.2 0.48 10.9 6.1 1.9 2 1 0 2 2 2 0 Type III cell invasion protein SipB Atg14 PF10186.9 ETO16259.1 - 0.67 9.0 4.2 7 5.6 2.8 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4298 PF14131.6 ETO16259.1 - 0.85 9.6 8.5 1.8 8.6 2.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) FlaC_arch PF05377.11 ETO16259.1 - 1.9 9.0 4.9 3.1 8.2 0.4 2.9 2 2 0 2 2 2 0 Flagella accessory protein C (FlaC) TSNAXIP1_N PF15739.5 ETO16259.1 - 2.7 8.4 9.6 12 6.3 5.2 2.7 3 0 0 3 3 3 0 Translin-associated factor X-interacting N-terminus Nefa_Nip30_N PF10187.9 ETO16261.1 - 0.00023 21.5 2.9 0.00044 20.6 2.9 1.5 1 0 0 1 1 1 1 N-terminal domain of NEFA-interacting nuclear protein NIP30 Mannitol_dh PF01232.23 ETO16261.1 - 0.072 13.3 1.3 0.18 12.0 1.3 1.6 1 1 1 2 2 2 0 Mannitol dehydrogenase Rossmann domain TMA7 PF09072.10 ETO16261.1 - 6.4 7.7 10.1 0.39 11.6 1.4 2.7 3 1 1 4 4 4 0 Translation machinery associated TMA7 AAA PF00004.29 ETO16263.1 - 4.1e-37 127.5 0.2 1e-36 126.3 0.1 1.8 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) PDZ_6 PF17820.1 ETO16263.1 - 9.5e-07 28.6 0.0 2.3e-06 27.4 0.0 1.7 1 0 0 1 1 1 1 PDZ domain FYVE PF01363.21 ETO16263.1 - 1.7e-06 28.0 13.1 4.5e-06 26.7 13.1 1.8 1 0 0 1 1 1 1 FYVE zinc finger PDZ PF00595.24 ETO16263.1 - 1.8e-06 28.2 0.0 4.5e-06 26.9 0.0 1.7 1 0 0 1 1 1 1 PDZ domain AAA_lid_3 PF17862.1 ETO16263.1 - 2.5e-06 27.2 0.0 5.8e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain RuvB_N PF05496.12 ETO16263.1 - 9.8e-05 22.2 0.0 0.00025 20.8 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain MIT PF04212.18 ETO16263.1 - 0.00032 20.7 0.0 0.0012 18.9 0.0 1.9 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA_5 PF07728.14 ETO16263.1 - 0.00047 20.2 0.0 0.0032 17.5 0.0 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) TIP49 PF06068.13 ETO16263.1 - 0.0046 16.2 0.0 0.0091 15.2 0.0 1.4 1 0 0 1 1 1 1 TIP49 P-loop domain Mg_chelatase PF01078.21 ETO16263.1 - 0.0074 15.7 0.0 0.022 14.1 0.0 1.7 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ETO16263.1 - 0.0085 16.4 0.2 0.81 10.0 0.2 2.6 1 1 0 1 1 1 1 AAA domain ABC2_membrane_3 PF12698.7 ETO16263.1 - 0.046 12.8 2.8 0.092 11.8 2.8 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein PDZ_2 PF13180.6 ETO16263.1 - 0.062 13.6 0.0 0.26 11.6 0.0 2.1 1 0 0 1 1 1 0 PDZ domain AAA_16 PF13191.6 ETO16263.1 - 0.099 13.0 0.1 0.87 9.9 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain IstB_IS21 PF01695.17 ETO16263.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_18 PF13238.6 ETO16263.1 - 0.39 11.3 6.3 1 9.9 0.0 3.4 3 0 0 3 3 2 0 AAA domain zf-CCHC_2 PF13696.6 ETO16263.1 - 3.2 7.7 7.3 0.79 9.6 0.4 2.5 2 0 0 2 2 2 0 Zinc knuckle zinc-ribbons_6 PF07191.12 ETO16263.1 - 5 7.2 10.1 1.1 9.3 4.3 2.4 1 1 1 2 2 2 0 zinc-ribbons PDZ PF00595.24 ETO16264.1 - 0.13 12.6 0.1 0.23 11.8 0.1 1.4 1 0 0 1 1 1 0 PDZ domain DUF5436 PF17504.2 ETO16264.1 - 1.9 8.9 6.6 8.4 6.8 2.4 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5436) LapA_dom PF06305.11 ETO16265.1 - 0.19 11.6 1.4 0.74 9.7 0.4 2.4 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain FixQ PF05545.11 ETO16265.1 - 0.42 10.6 1.4 1.4 9.0 1.4 1.9 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Exo_endo_phos PF03372.23 ETO16266.1 - 3.7e-09 36.4 0.0 6.5e-06 25.8 0.0 2.6 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family NopRA1 PF16201.5 ETO16266.1 - 0.088 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 Nucleolar pre-ribosomal-associated protein 1 CDC45 PF02724.14 ETO16266.1 - 0.23 9.7 11.3 0.32 9.2 11.3 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO16266.1 - 0.61 9.3 5.0 0.92 8.7 5.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO16266.1 - 1.3 7.7 9.8 1.9 7.2 9.8 1.3 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO16266.1 - 6.8 4.9 12.7 9.6 4.4 12.7 1.1 1 0 0 1 1 1 0 Menin RP-C_C PF11800.8 ETO16266.1 - 9.8 6.2 7.4 18 5.4 7.4 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region Gly_transf_sug PF04488.15 ETO16267.1 - 3.7e-14 53.1 0.9 8.9e-14 51.9 0.9 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ETO16267.1 - 0.00079 18.9 6.2 0.00096 18.6 5.0 1.9 1 1 0 1 1 1 1 Capsular polysaccharide synthesis protein MNSV_P7B PF06692.11 ETO16269.1 - 0.019 15.0 0.0 0.056 13.5 0.0 1.7 1 0 0 1 1 1 0 Melon necrotic spot virus P7B protein CtnDOT_TraJ PF07863.11 ETO16269.1 - 0.1 13.3 0.1 0.2 12.3 0.1 1.6 1 0 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon Lactamase_B PF00753.27 ETO16270.1 - 7.6e-10 39.1 0.0 9.3e-10 38.8 0.0 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETO16270.1 - 4.4e-09 36.1 0.0 7.6e-09 35.4 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Alkyl_sulf_dimr PF14863.6 ETO16271.1 - 4.4e-16 59.6 0.1 1.5e-15 57.9 0.1 1.8 1 1 0 1 1 1 1 Alkyl sulfatase dimerisation UCH PF00443.29 ETO16273.1 - 1.2e-13 51.2 0.3 1.5e-13 50.8 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF2681 PF10883.8 ETO16273.1 - 0.06 13.8 0.7 0.62 10.5 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DnaB PF00772.21 ETO16273.1 - 0.09 12.9 0.0 0.41 10.7 0.0 2.1 2 0 0 2 2 2 0 DnaB-like helicase N terminal domain UCH_1 PF13423.6 ETO16273.1 - 0.31 10.6 3.9 3.8 7.0 3.9 2.1 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase MIF4G PF02854.19 ETO16273.1 - 1.6 8.3 6.0 1 8.9 0.2 2.8 2 1 1 3 3 3 0 MIF4G domain ZapB PF06005.12 ETO16274.1 - 0.0097 16.3 3.3 0.0097 16.3 3.3 3.4 1 1 2 3 3 3 1 Cell division protein ZapB DivIC PF04977.15 ETO16274.1 - 0.21 11.3 0.2 0.21 11.3 0.2 3.5 3 1 1 4 4 4 0 Septum formation initiator DP PF08781.10 ETO16274.1 - 0.27 11.1 10.0 0.057 13.3 5.6 1.9 1 1 0 2 2 2 0 Transcription factor DP TPR_MLP1_2 PF07926.12 ETO16274.1 - 0.4 10.8 16.9 2.2 8.3 2.4 2.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4164 PF13747.6 ETO16274.1 - 0.5 10.7 7.7 19 5.6 0.5 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) YabA PF06156.13 ETO16274.1 - 0.51 11.0 17.1 1.3 9.7 1.8 2.9 1 1 1 2 2 2 0 Initiation control protein YabA PRKG1_interact PF15898.5 ETO16274.1 - 1 10.3 15.6 52 4.8 15.6 2.7 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Jnk-SapK_ap_N PF09744.9 ETO16274.1 - 1.5 9.1 14.3 2.5 8.3 14.3 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 TALPID3 PF15324.6 ETO16274.1 - 8.5 3.9 8.2 10 3.6 8.2 1.0 1 0 0 1 1 1 0 Hedgehog signalling target adh_short PF00106.25 ETO16275.1 - 6.7e-25 87.7 0.0 6.3e-24 84.5 0.0 2.2 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO16275.1 - 4.5e-12 46.0 0.0 3.7e-11 43.0 0.0 2.3 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO16275.1 - 1.1e-07 31.9 0.0 1.7e-07 31.3 0.0 1.4 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETO16275.1 - 0.0077 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ETO16275.1 - 0.0094 15.1 0.1 0.061 12.5 0.1 2.2 2 1 0 2 2 2 1 Male sterility protein Polysacc_synt_2 PF02719.15 ETO16275.1 - 0.014 14.6 0.0 0.02 14.0 0.0 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Aminotran_5 PF00266.19 ETO16275.1 - 0.027 13.4 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Aminotransferase class-V GDP_Man_Dehyd PF16363.5 ETO16275.1 - 0.21 10.9 0.0 0.36 10.2 0.0 1.3 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Ank_2 PF12796.7 ETO16276.1 - 1.5e-05 25.5 0.0 6.7e-05 23.4 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO16276.1 - 3.9e-05 24.1 0.0 0.00072 20.1 0.0 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO16276.1 - 0.0083 16.5 0.1 2.5 8.7 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 ETO16276.1 - 0.016 15.7 0.0 23 6.0 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat CDC45 PF02724.14 ETO16276.1 - 0.059 11.7 0.1 0.05 11.9 0.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 ETO16276.1 - 0.071 12.5 4.2 0.092 12.1 4.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RXT2_N PF08595.11 ETO16276.1 - 0.094 12.7 2.9 0.14 12.1 2.9 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 ETO16276.1 - 0.1 10.7 5.1 0.13 10.3 5.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO16276.1 - 0.51 8.5 6.2 0.67 8.1 6.2 1.1 1 0 0 1 1 1 0 Nop14-like family EBV-NA3 PF05009.12 ETO16276.1 - 7.8 5.9 5.6 14 5.1 5.6 1.3 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) EF-hand_1 PF00036.32 ETO16277.1 - 1.2e-30 102.7 22.1 1.2e-07 30.7 1.0 4.7 4 1 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO16277.1 - 7.6e-25 87.2 11.9 4.3e-13 49.5 1.4 3.4 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO16277.1 - 2.9e-23 79.8 18.4 7e-07 28.7 0.1 5.1 3 3 3 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 ETO16277.1 - 2.1e-20 71.2 21.3 8.3e-07 28.2 1.1 5.2 4 2 2 6 6 6 4 EF hand EF-hand_8 PF13833.6 ETO16277.1 - 3.9e-17 61.8 19.9 4.7e-09 36.0 2.9 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 ETO16277.1 - 4.6e-08 33.0 8.0 3.5e-05 23.7 0.3 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO16277.1 - 1.5e-07 31.7 1.7 0.0022 18.3 0.2 2.3 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETO16277.1 - 3.2e-06 27.4 3.4 0.00045 20.5 0.1 3.2 3 1 0 3 3 3 1 EF-hand domain Caleosin PF05042.13 ETO16277.1 - 8.4e-05 22.6 1.0 0.035 14.0 0.0 3.1 1 1 2 3 3 3 1 Caleosin related protein Dockerin_1 PF00404.18 ETO16277.1 - 0.0006 20.0 4.4 0.86 9.8 0.2 3.7 3 1 0 4 4 4 2 Dockerin type I domain TerB PF05099.13 ETO16277.1 - 0.003 17.5 2.5 0.043 13.8 0.0 2.9 1 1 1 3 3 3 1 Tellurite resistance protein TerB EF-hand_14 PF17959.1 ETO16277.1 - 0.0044 17.3 3.2 0.024 15.0 0.0 2.9 2 1 1 3 3 3 1 EF-hand domain Armet PF10208.9 ETO16277.1 - 0.023 14.6 0.1 18 5.3 0.0 2.9 2 1 1 3 3 3 0 Degradation arginine-rich protein for mis-folding SurA_N_2 PF13623.6 ETO16277.1 - 0.035 14.0 1.4 0.094 12.6 0.4 2.2 1 1 1 2 2 2 0 SurA N-terminal domain DUF3349 PF11829.8 ETO16277.1 - 0.13 13.1 0.2 2 9.2 0.1 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF3349) DNA_pol_phi PF04931.13 ETO16279.1 - 0.027 12.6 29.7 0.038 12.1 29.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO16279.1 - 0.61 8.2 33.2 0.71 8.0 33.2 1.1 1 0 0 1 1 1 0 Nop14-like family FYDLN_acid PF09538.10 ETO16280.1 - 0.28 11.9 12.3 0.29 11.8 12.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Pox_Ag35 PF03286.14 ETO16280.1 - 0.91 9.3 10.6 0.89 9.3 10.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO16280.1 - 1.7 6.6 17.8 1.9 6.5 17.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi RXT2_N PF08595.11 ETO16280.1 - 1.9 8.5 12.0 2 8.4 12.0 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal Ribosomal_60s PF00428.19 ETO16280.1 - 7.6 7.2 12.3 11 6.7 12.3 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein NOA36 PF06524.12 ETO16280.1 - 8.2 5.6 17.7 9.1 5.5 17.7 1.0 1 0 0 1 1 1 0 NOA36 protein DUF4820 PF16091.5 ETO16280.1 - 9.3 5.5 7.8 9 5.6 7.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RNA_pol_3_Rpc31 PF11705.8 ETO16280.1 - 9.5 6.4 20.2 10 6.3 20.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Alpha_kinase PF02816.18 ETO16281.1 - 5.3e-47 160.3 0.1 5.3e-47 160.3 0.1 1.8 2 1 0 2 2 2 1 Alpha-kinase family mRNA_cap_enzyme PF01331.19 ETO16282.1 - 6.4e-08 32.7 0.0 1.1e-07 31.9 0.0 1.4 1 0 0 1 1 1 1 mRNA capping enzyme, catalytic domain DSPc PF00782.20 ETO16282.1 - 0.019 14.8 0.0 0.038 13.8 0.0 1.4 1 0 0 1 1 1 0 Dual specificity phosphatase, catalytic domain CHAT PF12770.7 ETO16283.1 - 6.6e-10 38.9 0.1 9.1e-10 38.4 0.1 1.2 1 0 0 1 1 1 1 CHAT domain Peptidase_C25 PF01364.18 ETO16283.1 - 0.012 14.8 0.2 0.016 14.4 0.2 1.2 1 0 0 1 1 1 0 Peptidase family C25 BKACE PF05853.12 ETO16283.1 - 0.017 14.5 0.0 0.025 13.9 0.0 1.2 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme PhyH PF05721.13 ETO16285.1 - 3.8e-42 144.9 0.0 5.2e-42 144.5 0.0 1.2 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) AMP-binding PF00501.28 ETO16286.1 - 0.24 9.9 0.0 0.25 9.9 0.0 1.1 1 0 0 1 1 1 0 AMP-binding enzyme Capsule_synth PF05159.14 ETO16287.1 - 0.018 14.5 0.0 0.037 13.5 0.0 1.5 2 0 0 2 2 2 0 Capsule polysaccharide biosynthesis protein Pkinase PF00069.25 ETO16288.1 - 2.6e-30 105.7 0.3 2.6e-30 105.7 0.3 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16288.1 - 3.5e-16 59.3 0.0 6.5e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ETO16288.1 - 2.1e-05 25.0 0.1 5.8e-05 23.5 0.1 1.8 1 0 0 1 1 1 1 PH domain EF-hand_1 PF00036.32 ETO16288.1 - 0.082 12.5 0.0 0.31 10.7 0.0 2.1 1 0 0 1 1 1 0 EF hand APH PF01636.23 ETO16288.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family CDC45 PF02724.14 ETO16288.1 - 0.25 9.6 9.3 0.027 12.8 5.0 1.7 2 0 0 2 2 2 0 CDC45-like protein DZR PF12773.7 ETO16288.1 - 2.8 8.1 4.6 6.1 7.0 3.3 2.2 2 1 0 2 2 2 0 Double zinc ribbon DNA_pol_phi PF04931.13 ETO16288.1 - 6.5 4.7 13.3 10 4.0 13.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi BNR_4 PF15892.5 ETO16289.1 - 0.026 13.9 0.0 0.04 13.3 0.0 1.3 1 0 0 1 1 1 0 BNR repeat-containing family member Pkinase PF00069.25 ETO16289.1 - 0.072 12.4 0.0 0.14 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein kinase domain Glyco_transf_8C PF08437.10 ETO16290.1 - 7.4 6.8 9.2 9.9 6.3 0.2 3.6 4 1 0 4 4 4 0 Glycosyl transferase family 8 C-terminal N6_Mtase PF02384.16 ETO16291.1 - 9.6e-30 103.9 0.2 1.2e-29 103.6 0.2 1.2 1 0 0 1 1 1 1 N-6 DNA Methylase rve_3 PF13683.6 ETO16291.1 - 1.8e-07 30.8 0.7 3e-06 26.9 0.2 2.4 1 1 1 2 2 2 1 Integrase core domain rve PF00665.26 ETO16291.1 - 2e-05 24.8 0.0 3.2e-05 24.1 0.0 1.3 1 0 0 1 1 1 1 Integrase core domain UPF0020 PF01170.18 ETO16291.1 - 0.00054 19.7 0.0 0.00083 19.1 0.0 1.3 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 DnaJ PF00226.31 ETO16292.1 - 2e-07 31.0 0.2 4.6e-07 29.9 0.2 1.7 1 0 0 1 1 1 1 DnaJ domain Cor1 PF04803.12 ETO16292.1 - 0.061 13.5 0.3 21 5.3 0.0 2.9 2 0 0 2 2 2 0 Cor1/Xlr/Xmr conserved region N2227 PF07942.12 ETO16293.1 - 4.2e-85 285.2 0.6 9.4e-85 284.1 0.6 1.5 1 1 0 1 1 1 1 N2227-like protein Methyltransf_23 PF13489.6 ETO16293.1 - 0.00011 22.1 0.0 0.00031 20.6 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO16293.1 - 0.013 15.3 0.0 3.7 7.3 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_11 PF08241.12 ETO16293.1 - 0.015 15.9 0.0 0.39 11.4 0.0 2.3 2 0 0 2 2 2 0 Methyltransferase domain Pyr_redox_dim PF02852.22 ETO16294.1 - 9.3e-16 58.1 0.0 1.8e-15 57.1 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 ETO16294.1 - 4.3e-12 45.9 0.1 6.3e-12 45.3 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO16295.1 - 1e-12 48.5 0.0 1.2e-12 48.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO16295.1 - 8.7e-10 38.3 0.0 1.1e-09 38.0 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Apis_Csd PF11671.8 ETO16296.1 - 4.1 7.4 20.6 0.092 12.8 2.5 2.8 2 0 0 2 2 2 0 Complementary sex determiner protein LPD1 PF18796.1 ETO16297.1 - 0.0076 16.3 0.0 0.011 15.9 0.0 1.5 1 1 0 1 1 1 1 Large polyvalent protein-associated domain 1 PCM1_C PF15717.5 ETO16298.1 - 3 6.4 29.7 1.2 7.7 27.6 1.3 1 1 0 1 1 1 0 Pericentriolar material 1 C terminus Macoilin PF09726.9 ETO16298.1 - 4 5.9 28.1 5.6 5.4 28.1 1.3 1 0 0 1 1 1 0 Macoilin family COPIIcoated_ERV PF07970.12 ETO16299.1 - 2.1e-27 96.4 0.9 3.1e-27 95.9 0.9 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter ESSS PF10183.9 ETO16299.1 - 0.011 15.9 0.2 0.023 14.9 0.1 1.7 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) UPRTase PF14681.6 ETO16300.1 - 0.049 13.1 0.0 0.13 11.6 0.0 1.6 2 0 0 2 2 2 0 Uracil phosphoribosyltransferase CD36 PF01130.21 ETO16301.1 - 1.4e-14 53.5 6.2 3.5e-14 52.2 1.5 2.1 2 0 0 2 2 2 2 CD36 family zinc_ribbon_16 PF17034.5 ETO16301.1 - 0.11 12.7 0.5 0.24 11.6 0.1 1.7 2 0 0 2 2 2 0 Zinc-ribbon like family SNARE PF05739.19 ETO16302.1 - 0.0032 17.4 7.3 0.0032 17.4 7.3 2.5 2 1 0 2 2 2 1 SNARE domain DUF4407 PF14362.6 ETO16302.1 - 0.34 10.2 8.9 0.92 8.8 8.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Sec20 PF03908.13 ETO16302.1 - 1.7 8.6 11.5 7.2 6.6 1.1 3.4 2 2 1 3 3 3 0 Sec20 FSH1 PF03959.13 ETO16303.1 - 2e-07 30.9 0.2 9.5e-07 28.7 0.2 2.0 1 1 0 1 1 1 1 Serine hydrolase (FSH1) Peptidase_S9 PF00326.21 ETO16303.1 - 6.6e-07 29.0 0.3 0.0001 21.9 0.0 2.2 1 1 1 2 2 2 2 Prolyl oligopeptidase family UPF0227 PF05728.12 ETO16303.1 - 1.1e-05 25.4 0.5 0.0078 16.2 0.1 2.2 2 0 0 2 2 2 2 Uncharacterised protein family (UPF0227) Abhydrolase_1 PF00561.20 ETO16303.1 - 1.9e-05 24.5 0.1 0.069 12.8 0.0 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO16303.1 - 0.00017 22.3 0.0 0.00027 21.6 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETO16303.1 - 0.00034 20.0 0.2 0.0017 17.7 0.2 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 ETO16303.1 - 0.0062 16.4 0.3 1.9 8.2 0.0 2.2 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_4 PF08386.10 ETO16303.1 - 0.031 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 TAP-like protein Abhydrolase_3 PF07859.13 ETO16303.1 - 0.063 13.1 0.0 0.095 12.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold Esterase PF00756.20 ETO16303.1 - 0.12 12.0 0.3 0.33 10.5 0.3 1.7 1 1 0 1 1 1 0 Putative esterase 3HBOH PF10605.9 ETO16303.1 - 0.28 9.4 0.0 0.33 9.1 0.0 1.1 1 0 0 1 1 1 0 3HB-oligomer hydrolase (3HBOH) Peptidase_M48_N PF16491.5 ETO16303.1 - 0.59 10.0 9.1 0.59 10.0 3.9 2.6 3 0 0 3 3 3 0 CAAX prenyl protease N-terminal, five membrane helices WD40 PF00400.32 ETO16304.1 - 6.4e-22 77.4 8.3 0.0011 19.7 0.0 7.5 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16304.1 - 5.5e-14 52.2 0.4 0.00027 21.1 0.1 6.1 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16304.1 - 1.5e-08 34.0 0.1 0.088 11.7 0.0 4.7 3 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16304.1 - 6.7e-07 29.4 6.0 0.0004 20.3 0.0 4.3 3 1 2 5 5 5 2 Eukaryotic translation initiation factor eIF2A Kelch_1 PF01344.25 ETO16304.1 - 8.5e-07 28.5 1.1 0.11 12.1 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO16304.1 - 5.2e-05 23.4 3.1 0.28 11.6 0.1 3.7 3 0 0 3 3 2 2 Kelch motif PD40 PF07676.12 ETO16304.1 - 0.0013 18.6 0.6 0.21 11.6 0.0 3.8 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO16304.1 - 0.0017 16.9 0.0 0.019 13.5 0.0 2.2 2 0 0 2 2 2 1 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO16304.1 - 0.0028 17.6 4.6 1.1 9.3 0.2 3.6 3 1 0 3 3 3 2 Kelch motif Nup160 PF11715.8 ETO16304.1 - 0.0048 15.6 0.1 5.9 5.4 0.0 3.5 2 2 1 4 4 4 1 Nucleoporin Nup120/160 Kelch_5 PF13854.6 ETO16304.1 - 0.036 14.0 3.1 0.78 9.8 0.3 3.4 3 0 0 3 3 3 0 Kelch motif Biotin_lipoyl_2 PF13533.6 ETO16304.1 - 0.23 11.3 0.8 11 6.0 0.1 2.7 3 0 0 3 3 3 0 Biotin-lipoyl like DUF3439 PF11921.8 ETO16305.1 - 0.033 14.1 1.7 0.095 12.7 1.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) UCH PF00443.29 ETO16306.1 - 2.2e-22 79.8 0.0 7.3e-21 74.8 0.0 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO16306.1 - 1.5e-05 24.8 0.0 3.8e-05 23.4 0.0 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Actin PF00022.19 ETO16307.1 - 4.8e-14 51.8 0.0 6e-14 51.5 0.0 1.0 1 0 0 1 1 1 1 Actin PilM_2 PF11104.8 ETO16307.1 - 0.014 14.5 0.0 0.021 13.9 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; RCC1_2 PF13540.6 ETO16308.1 - 1.3e-05 24.8 1.6 4.9e-05 23.0 0.6 2.4 2 1 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO16308.1 - 0.0067 17.0 0.0 0.32 11.7 0.0 2.8 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat Rap_GAP PF02145.15 ETO16309.1 - 3e-14 53.0 0.1 7.6e-14 51.7 0.1 1.6 1 0 0 1 1 1 1 Rap/ran-GAP Phage_Gp23 PF10669.9 ETO16309.1 - 0.074 13.4 4.0 0.28 11.5 4.0 2.0 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) DUF1925 PF09094.11 ETO16309.1 - 0.1 13.0 0.4 0.4 11.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1925) PT PF04886.12 ETO16311.1 - 2.9e-06 26.7 28.6 0.037 13.6 3.5 3.4 2 1 1 3 3 3 3 PT repeat DUF3377 PF11857.8 ETO16311.1 - 0.013 15.4 0.2 0.031 14.2 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) MmcB-like PF06319.12 ETO16311.1 - 0.017 14.8 0.1 0.03 14.0 0.1 1.3 1 0 0 1 1 1 0 DNA repair protein MmcB-like Insulin_TMD PF17870.1 ETO16311.1 - 0.021 14.9 2.8 0.021 14.9 2.8 1.9 2 0 0 2 2 2 0 Insulin receptor trans-membrane segment TMEM154 PF15102.6 ETO16311.1 - 0.042 13.8 0.5 0.042 13.8 0.5 2.7 4 0 0 4 4 4 0 TMEM154 protein family MGC-24 PF05283.11 ETO16311.1 - 0.48 10.9 5.5 0.2 12.1 2.2 1.9 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin OAD_gamma PF04277.13 ETO16312.1 - 0.3 11.7 6.0 0.24 12.0 2.8 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Dapper PF15268.6 ETO16313.1 - 0.0079 15.1 15.5 0.0085 15.0 15.5 1.1 1 0 0 1 1 1 1 Dapper CDK5_activator PF03261.15 ETO16313.1 - 0.4 10.2 19.4 0.52 9.8 19.4 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Macoilin PF09726.9 ETO16313.1 - 2.3 6.7 21.0 2.6 6.5 21.0 1.1 1 0 0 1 1 1 0 Macoilin family Spo7 PF03907.13 ETO16314.1 - 0.029 13.9 1.1 0.033 13.7 1.1 1.1 1 0 0 1 1 1 0 Spo7-like protein ATG11 PF10377.9 ETO16314.1 - 0.083 13.0 7.1 0.1 12.7 7.1 1.3 1 0 0 1 1 1 0 Autophagy-related protein 11 XRN_M PF17846.1 ETO16314.1 - 0.12 11.3 3.3 0.12 11.3 3.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain UNC-79 PF14776.6 ETO16314.1 - 0.32 9.7 2.0 0.39 9.4 2.0 1.0 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 Nup88 PF10168.9 ETO16314.1 - 0.33 8.7 6.4 0.37 8.6 6.4 1.0 1 0 0 1 1 1 0 Nuclear pore component Peptidase_S49_N PF08496.10 ETO16314.1 - 0.49 10.4 12.3 0.59 10.2 12.3 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RNA_polI_A34 PF08208.11 ETO16316.1 - 0.037 14.1 15.3 1.8 8.6 0.0 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 RPE65 PF03055.15 ETO16316.1 - 0.21 10.7 1.0 0.45 9.6 0.8 1.5 1 1 1 2 2 2 0 Retinal pigment epithelial membrane protein PDCD2_C PF04194.13 ETO16316.1 - 3.8 7.5 9.1 5.8 7.0 9.1 1.2 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Dev_Cell_Death PF10539.9 ETO16318.1 - 1.1e-32 112.6 0.0 2e-32 111.7 0.0 1.5 1 0 0 1 1 1 1 Development and cell death domain Ribosomal_L14e PF01929.17 ETO16319.1 - 9.6 6.8 9.3 84 3.8 1.8 3.1 3 0 0 3 3 3 0 Ribosomal protein L14 Ras PF00071.22 ETO16321.1 - 0.0052 16.4 0.4 0.13 11.8 0.4 2.5 1 1 0 1 1 1 1 Ras family Cys_rich_VLP PF14194.6 ETO16321.1 - 0.04 14.0 1.9 0.065 13.4 1.9 1.4 1 0 0 1 1 1 0 Cysteine-rich VLP TctB PF07331.11 ETO16322.1 - 0.021 15.1 3.7 63 3.8 0.0 3.8 2 2 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family DUF4366 PF14283.6 ETO16322.1 - 0.027 14.5 0.0 0.62 10.1 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) AOX PF01786.17 ETO16322.1 - 3.2 7.3 5.5 8.2 5.9 3.4 2.3 2 0 0 2 2 2 0 Alternative oxidase WD40 PF00400.32 ETO16323.1 - 9.8e-58 190.8 16.9 5.3e-10 39.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16323.1 - 9.4e-18 64.3 4.9 5.6e-05 23.3 0.4 5.5 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16323.1 - 3e-14 53.0 3.7 4.3e-07 29.6 0.2 4.1 2 2 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO16323.1 - 7.9e-11 41.3 7.4 0.048 12.3 0.0 5.7 2 1 4 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO16323.1 - 1.1e-05 24.1 3.4 0.004 15.7 0.1 3.6 2 1 2 4 4 4 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO16323.1 - 0.0001 21.2 11.2 0.51 9.0 0.3 4.8 1 1 5 6 6 6 4 Nup133 N terminal like PD40 PF07676.12 ETO16323.1 - 0.044 13.7 2.0 29 4.8 0.1 4.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 ETO16323.1 - 0.045 13.2 0.0 0.92 8.9 0.0 2.5 1 1 0 3 3 3 0 Domain of unknown function (DUF5046) PIP5K PF01504.18 ETO16324.1 - 8.2e-37 126.9 0.5 1e-29 103.6 0.1 4.2 3 2 1 4 4 4 2 Phosphatidylinositol-4-phosphate 5-Kinase DUF4487 PF14868.6 ETO16324.1 - 0.036 12.9 0.0 0.069 12.0 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4487) CENP-B_dimeris PF09026.10 ETO16324.1 - 5.5 7.4 9.7 0.75 10.2 4.5 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain MMPL PF03176.15 ETO16326.1 - 5.3e-11 42.0 0.0 7.1e-11 41.6 0.0 1.1 1 0 0 1 1 1 1 MMPL family Sulfotransfer_3 PF13469.6 ETO16327.1 - 1.4e-12 48.5 5.5 2.5e-12 47.6 3.9 2.0 2 0 0 2 2 2 1 Sulfotransferase family Sulfotransfer_1 PF00685.27 ETO16327.1 - 2e-08 34.0 7.4 2.2e-08 33.9 6.5 1.3 1 1 0 1 1 1 1 Sulfotransferase domain Abhydrolase_1 PF00561.20 ETO16327.1 - 0.12 12.0 0.4 0.21 11.2 0.0 1.6 2 0 0 2 2 2 0 alpha/beta hydrolase fold COX14 PF14880.6 ETO16327.1 - 0.36 10.7 2.8 5.1 7.0 0.0 3.1 3 0 0 3 3 3 0 Cytochrome oxidase c assembly PH PF00169.29 ETO16328.1 - 1.9e-08 34.7 7.0 3.9e-08 33.8 2.7 3.0 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO16328.1 - 5.8e-06 26.7 5.6 5.8e-06 26.7 5.6 2.8 2 1 0 2 2 2 1 Pleckstrin homology domain RNA_pol_3_Rpc31 PF11705.8 ETO16328.1 - 0.011 16.0 7.2 0.017 15.4 7.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 PH_8 PF15409.6 ETO16328.1 - 0.03 14.6 3.1 0.3 11.4 1.1 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain Astro_capsid_p PF12226.8 ETO16328.1 - 0.052 12.7 3.6 0.076 12.2 3.6 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF809 PF05663.11 ETO16328.1 - 0.058 13.5 2.2 0.11 12.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF809) CBM_3 PF00942.18 ETO16328.1 - 0.1 13.0 1.9 0.9 10.0 0.2 2.4 2 0 0 2 2 2 0 Cellulose binding domain DNA_pol_phi PF04931.13 ETO16328.1 - 0.25 9.4 11.3 0.34 9.0 11.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO16328.1 - 1 7.5 11.0 1.4 7.0 11.0 1.2 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ETO16328.1 - 3.6 6.8 10.6 5.7 6.2 10.6 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 ETO16328.1 - 4 6.5 12.6 6 5.9 12.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PH PF00169.29 ETO16329.1 - 3.8e-28 98.1 2.9 5e-11 43.1 0.5 3.3 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 ETO16329.1 - 3.3e-12 46.8 7.5 7.3e-06 26.4 0.8 3.3 3 0 0 3 3 3 2 Pleckstrin homology domain PH_8 PF15409.6 ETO16329.1 - 7.3e-09 35.8 7.1 0.0039 17.4 0.3 3.8 4 0 0 4 4 4 2 Pleckstrin homology domain PH_3 PF14593.6 ETO16329.1 - 7.9e-07 29.1 1.5 0.27 11.4 0.1 3.4 3 0 0 3 3 3 3 PH domain C2 PF00168.30 ETO16331.1 - 6e-39 132.5 0.1 6.9e-18 64.8 0.0 2.9 3 0 0 3 3 3 2 C2 domain Aconitase PF00330.20 ETO16331.1 - 0.0022 17.1 6.4 0.0037 16.3 6.4 1.3 1 0 0 1 1 1 1 Aconitase family (aconitate hydratase) PTEN_C2 PF10409.9 ETO16331.1 - 0.029 14.1 0.0 0.11 12.3 0.0 2.0 1 0 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein DDHD PF02862.17 ETO16331.1 - 2.3 8.3 7.3 5 7.2 7.3 1.6 1 0 0 1 1 1 0 DDHD domain GAGA_bind PF06217.12 ETO16331.1 - 9.2 6.5 18.8 16 5.7 18.8 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family SPRY PF00622.28 ETO16332.1 - 4e-13 49.5 0.0 6.5e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 SPRY domain UQ_con PF00179.26 ETO16332.1 - 4.9e-06 26.2 0.2 7.8e-06 25.6 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Pam17 PF08566.10 ETO16333.1 - 0.069 13.0 1.3 4.7 7.0 1.3 2.5 1 1 0 1 1 1 0 Mitochondrial import protein Pam17 Ribosomal_L7Ae PF01248.26 ETO16334.1 - 1.2e-14 53.8 0.2 1e-08 34.7 0.1 2.5 3 0 0 3 3 3 2 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family VWA_2 PF13519.6 ETO16335.1 - 0.071 13.8 0.0 0.08 13.6 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain TssR PF17643.1 ETO16335.1 - 0.099 10.6 0.0 0.11 10.4 0.0 1.1 1 0 0 1 1 1 0 Type VI secretion system, TssR DUF4148 PF13663.6 ETO16336.1 - 0.1 12.8 2.2 0.19 11.9 2.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) SbcCD_C PF13558.6 ETO16336.1 - 0.17 12.2 0.2 0.26 11.6 0.2 1.2 1 0 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ArfGap PF01412.18 ETO16337.1 - 2.6e-09 37.2 1.2 5.2e-09 36.2 0.0 2.0 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf zf-C2H2_11 PF16622.5 ETO16339.1 - 0.00076 19.2 0.6 0.0019 17.9 0.6 1.7 1 0 0 1 1 1 1 zinc-finger C2H2-type zf-C2H2 PF00096.26 ETO16339.1 - 0.002 18.4 1.6 0.0067 16.8 1.6 2.0 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO16339.1 - 0.0029 18.3 1.6 0.013 16.3 1.6 2.2 1 0 0 1 1 1 1 C2H2-type zinc finger PH_RBD PF12068.8 ETO16339.1 - 0.01 15.4 0.5 0.01 15.4 0.5 2.1 2 0 0 2 2 2 0 Rab-binding domain (RBD) Apis_Csd PF11671.8 ETO16339.1 - 0.017 15.2 8.1 0.017 15.2 8.1 3.2 4 0 0 4 4 4 0 Complementary sex determiner protein zf-Di19 PF05605.12 ETO16339.1 - 0.065 13.5 1.0 0.18 12.1 1.0 1.8 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 ETO16339.1 - 0.59 10.7 6.3 4.3 7.9 0.7 2.8 2 0 0 2 2 2 0 Zinc-finger double domain WD40 PF00400.32 ETO16340.1 - 2.1e-124 401.8 47.7 1.8e-09 38.1 0.1 16.3 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16340.1 - 4.4e-24 84.6 16.3 0.019 15.3 0.0 11.6 1 1 13 14 14 14 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16340.1 - 2.8e-11 43.3 13.6 0.17 11.2 0.1 7.4 5 3 3 8 8 8 5 WD40-like domain Nup160 PF11715.8 ETO16340.1 - 3.8e-11 42.3 31.0 0.7 8.5 0.0 12.9 3 2 8 13 13 13 5 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO16340.1 - 2.2e-07 30.9 0.5 6.2 7.0 0.0 7.0 5 3 2 7 7 6 1 Strictosidine synthase Pentapeptide PF00805.22 ETO16340.1 - 4.7e-07 29.3 2.5 1.1e-06 28.2 2.5 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DUF5046 PF16465.5 ETO16340.1 - 5.2e-06 26.1 0.3 1.3 8.4 0.0 5.2 3 2 3 6 6 6 1 Domain of unknown function (DUF5046) Pentapeptide_4 PF13599.6 ETO16340.1 - 0.0005 20.2 0.2 0.0014 18.7 0.2 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO16340.1 - 0.00068 19.7 0.3 70 3.6 0.0 6.1 6 1 1 7 7 7 0 Domain of unknown function (DUF3475) Pentapeptide_3 PF13576.6 ETO16340.1 - 0.0035 17.5 0.7 0.012 15.8 0.7 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO16340.1 - 0.0043 16.4 11.7 11 5.2 0.1 7.5 4 2 5 10 10 10 0 Neuroblastoma-amplified sequence, N terminal Lectin_N PF03954.14 ETO16340.1 - 0.016 14.9 0.0 0.064 13.0 0.0 2.0 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF5319 PF17252.2 ETO16340.1 - 0.02 15.1 0.1 1.3e+02 2.8 0.0 5.0 2 2 4 6 6 6 0 Family of unknown function (DUF5319) DUF1797 PF08796.10 ETO16340.1 - 0.024 14.7 0.0 47 4.2 0.0 4.3 5 0 0 5 5 4 0 Protein of unknown function (DUF1797) Staphostatin_B PF09023.10 ETO16340.1 - 0.027 14.5 0.2 0.15 12.1 0.2 2.3 1 0 0 1 1 1 0 Staphostatin B Interfer-bind PF09294.10 ETO16340.1 - 0.076 13.3 0.2 0.46 10.8 0.2 2.4 1 0 0 1 1 1 0 Interferon-alpha/beta receptor, fibronectin type III TolB_N PF04052.13 ETO16340.1 - 0.1 12.8 4.4 1.7e+02 2.5 0.0 6.4 9 0 0 9 9 8 0 TolB amino-terminal domain DUF5570 PF17731.1 ETO16340.1 - 0.26 11.4 3.6 9.3 6.4 0.0 4.9 6 1 1 7 7 6 0 Family of unknown function (DUF5570) Fanconi_A PF03511.14 ETO16341.1 - 4.7 7.2 5.2 10 6.1 0.0 3.7 4 0 0 4 4 4 0 Fanconi anaemia group A protein Sin_N PF04801.13 ETO16344.1 - 1.6e-08 34.2 0.0 1.3e-07 31.2 0.0 2.1 1 1 1 2 2 2 1 Sin-like protein conserved region ELMO_CED12 PF04727.13 ETO16344.1 - 0.00032 20.9 0.1 0.00032 20.9 0.1 2.5 3 1 0 3 3 3 1 ELMO/CED-12 family YL1 PF05764.13 ETO16344.1 - 0.0012 19.0 27.4 0.0027 17.9 27.4 1.5 1 0 0 1 1 1 1 YL1 nuclear protein RskA PF10099.9 ETO16344.1 - 0.0031 17.8 8.8 0.0031 17.8 8.8 2.5 3 0 0 3 3 3 1 Anti-sigma-K factor rskA BUD22 PF09073.10 ETO16344.1 - 0.36 10.1 33.4 0.13 11.6 25.3 2.3 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 ETO16344.1 - 2.9 7.2 41.8 8.6 5.7 38.3 2.1 2 0 0 2 2 2 0 SDA1 PA26 PF04636.13 ETO16344.1 - 3.5 6.4 17.4 7.5 5.3 14.4 2.2 2 0 0 2 2 2 0 PA26 p53-induced protein (sestrin) TFIIA PF03153.13 ETO16344.1 - 8.7 6.2 61.5 5.1 7.0 24.2 2.2 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit DUF1387 PF07139.11 ETO16344.1 - 9.3 5.9 34.3 4.4 6.9 24.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) SpoVR PF04293.13 ETO16346.1 - 0.038 12.7 2.0 0.066 11.9 2.0 1.3 1 0 0 1 1 1 0 SpoVR like protein Cofac_haem_bdg PF04187.13 ETO16347.1 - 3.5e-38 131.8 0.0 4.4e-38 131.4 0.0 1.1 1 0 0 1 1 1 1 Haem-binding uptake, Tiki superfamily, ChaN XK-related PF09815.9 ETO16348.1 - 2.6e-05 23.5 4.9 2.6e-05 23.5 4.9 3.4 2 1 1 3 3 3 2 XK-related protein RTBV_P12 PF06361.11 ETO16349.1 - 0.38 11.2 5.4 7.5 7.0 0.5 2.5 2 0 0 2 2 2 0 Rice tungro bacilliform virus P12 protein Pkinase PF00069.25 ETO16350.1 - 4.1e-53 180.4 0.0 2.2e-52 178.1 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16350.1 - 1.8e-25 89.7 0.0 9.7e-25 87.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO16350.1 - 8.4e-25 84.4 12.4 2.7e-06 26.5 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 ETO16350.1 - 1.6e-19 68.4 7.2 3.7e-07 29.3 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO16350.1 - 5.4e-19 66.5 6.5 4.6e-06 26.1 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ETO16350.1 - 8.6e-19 67.8 13.2 2.7e-09 37.3 0.3 3.3 3 1 0 3 3 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO16350.1 - 6.4e-13 48.3 9.4 2.2e-05 24.2 0.3 4.2 2 1 2 4 4 4 3 EF-hand domain pair Kdo PF06293.14 ETO16350.1 - 8.9e-07 28.5 0.0 1.9e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.9 ETO16350.1 - 4.1e-06 27.1 13.5 0.0025 18.1 0.1 3.9 1 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region APH PF01636.23 ETO16350.1 - 0.00076 19.5 0.1 0.076 12.9 0.2 2.7 2 1 1 3 3 3 1 Phosphotransferase enzyme family EF-hand_9 PF14658.6 ETO16350.1 - 0.013 15.9 0.8 3.1 8.2 0.0 3.0 3 0 0 3 3 2 0 EF-hand domain BSMAP PF12280.8 ETO16350.1 - 0.12 12.5 3.0 0.25 11.5 3.0 1.5 1 0 0 1 1 1 0 Brain specific membrane anchored protein Atrophin-1 PF03154.15 ETO16350.1 - 0.13 10.6 5.3 0.19 10.0 5.3 1.1 1 0 0 1 1 1 0 Atrophin-1 family ATP11 PF06644.11 ETO16350.1 - 0.14 11.9 5.1 0.27 11.0 5.1 1.4 1 0 0 1 1 1 0 ATP11 protein CobT PF06213.12 ETO16350.1 - 0.34 10.3 9.6 0.57 9.5 9.6 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2722 PF10846.8 ETO16350.1 - 0.71 8.7 11.8 1.3 7.9 11.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) POX PF07526.11 ETO16350.1 - 1.2 9.7 8.4 0.18 12.4 4.1 1.8 2 0 0 2 2 1 0 Associated with HOX EF-hand_4 PF12763.7 ETO16350.1 - 2.1 8.3 13.2 18 5.3 2.6 4.0 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand DNA_pol_phi PF04931.13 ETO16350.1 - 2.6 6.1 16.5 3.9 5.5 16.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4770 PF15994.5 ETO16350.1 - 2.8 8.1 6.3 0.2 11.9 1.3 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4770) Presenilin PF01080.17 ETO16350.1 - 3.1 6.5 4.6 5.7 5.6 4.6 1.4 1 0 0 1 1 1 0 Presenilin NDK PF00334.19 ETO16351.1 - 4.3e-30 104.5 0.2 3.8e-29 101.4 0.1 2.3 2 0 0 2 2 2 1 Nucleoside diphosphate kinase Dpy-30 PF05186.13 ETO16351.1 - 0.005 16.5 0.0 0.013 15.2 0.0 1.7 1 0 0 1 1 1 1 Dpy-30 motif DUF2510 PF10708.9 ETO16352.1 - 0.048 13.4 0.6 7.4 6.4 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2510) RPN7 PF10602.9 ETO16353.1 - 0.27 10.9 0.1 0.27 10.9 0.1 3.2 2 1 2 4 4 4 0 26S proteasome subunit RPN7 CENP-Q PF13094.6 ETO16353.1 - 1.4 9.1 17.5 3.5 7.8 17.5 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Vps39_1 PF10366.9 ETO16353.1 - 1.4 9.2 4.6 27 5.1 2.7 2.7 2 1 0 2 2 2 0 Vacuolar sorting protein 39 domain 1 Presenilin PF01080.17 ETO16353.1 - 2.2 7.0 4.2 2.6 6.7 4.2 1.2 1 0 0 1 1 1 0 Presenilin U79_P34 PF03064.16 ETO16353.1 - 2.4 7.4 15.4 3.9 6.8 15.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF3584 PF12128.8 ETO16353.1 - 2.7 5.4 21.4 3.7 5.0 21.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Vps53_N PF04100.12 ETO16354.1 - 4.5e-27 95.0 2.7 5.5e-27 94.7 2.7 1.0 1 0 0 1 1 1 1 Vps53-like, N-terminal DUF2854 PF11016.8 ETO16354.1 - 0.01 15.8 0.1 0.021 14.7 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2854) KIP1 PF07765.12 ETO16354.1 - 0.034 14.3 0.5 0.21 11.8 0.2 2.4 1 1 2 3 3 3 0 KIP1-like protein CsiV PF10972.8 ETO16355.1 - 0.0092 15.7 1.0 0.011 15.5 1.0 1.2 1 0 0 1 1 1 1 Peptidoglycan-binding protein, CsiV FDF PF09532.10 ETO16355.1 - 0.069 14.0 2.1 0.079 13.8 2.1 1.2 1 0 0 1 1 1 0 FDF domain Aminotran_1_2 PF00155.21 ETO16359.1 - 0.049 12.8 0.1 0.1 11.8 0.0 1.5 2 0 0 2 2 2 0 Aminotransferase class I and II Calci_bind_CcbP PF11535.8 ETO16359.1 - 0.14 12.7 0.3 21 5.7 0.0 2.4 1 1 1 2 2 2 0 Calcium binding DUF3043 PF11241.8 ETO16359.1 - 0.15 12.1 0.3 0.25 11.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF2768 PF10966.8 ETO16359.1 - 7.7 7.0 7.9 47 4.5 0.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2768) OppC_N PF12911.7 ETO16361.1 - 0.011 15.7 0.1 0.026 14.5 0.0 1.7 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C DUF3021 PF11457.8 ETO16361.1 - 0.059 13.7 0.5 0.41 11.0 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3021) MGC-24 PF05283.11 ETO16362.1 - 0.0049 17.3 0.7 0.0086 16.5 0.7 1.4 1 0 0 1 1 1 1 Multi-glycosylated core protein 24 (MGC-24), sialomucin SLBP_RNA_bind PF15247.6 ETO16364.1 - 3.9e-24 84.5 0.5 3.9e-24 84.5 0.5 2.4 3 0 0 3 3 3 1 Histone RNA hairpin-binding protein RNA-binding domain ESSS PF10183.9 ETO16364.1 - 0.16 12.2 0.2 0.16 12.2 0.2 2.4 3 0 0 3 3 3 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) DUF1179 PF06678.11 ETO16365.1 - 4.5 7.3 4.9 4.2 7.4 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1179) vATP-synt_AC39 PF01992.16 ETO16366.1 - 1.9e-27 96.7 0.0 2.3e-27 96.4 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit CFIA_Pcf11 PF11526.8 ETO16367.1 - 0.2 12.1 8.7 2.5 8.7 3.6 2.3 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 DUF713 PF05218.14 ETO16367.1 - 1.1 9.0 5.3 2.9 7.6 0.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF713) UCH PF00443.29 ETO16368.1 - 7.8e-20 71.4 0.0 2.8e-19 69.6 0.0 1.7 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Bromodomain PF00439.25 ETO16371.1 - 3.9e-15 55.7 0.6 2.2e-10 40.5 0.0 3.7 2 2 1 3 3 3 2 Bromodomain NICE-3 PF07406.11 ETO16371.1 - 0.011 15.8 1.1 0.36 10.8 0.2 2.3 2 0 0 2 2 2 0 NICE-3 protein MMPL PF03176.15 ETO16373.1 - 4.5e-33 114.6 14.6 9.9e-32 110.2 14.6 2.0 1 1 0 1 1 1 1 MMPL family DUF3761 PF12587.8 ETO16374.1 - 0.061 13.8 0.8 0.061 13.8 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) FYVE PF01363.21 ETO16375.1 - 6.1e-20 71.1 16.7 6.1e-20 71.1 16.7 1.7 2 0 0 2 2 2 1 FYVE zinc finger DUF4798 PF16055.5 ETO16375.1 - 0.075 13.3 4.3 0.21 11.9 4.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4798) FSA_C PF10479.9 ETO16375.1 - 2.1 6.4 9.0 2.8 5.9 9.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 ETO16375.1 - 5.5 7.0 30.5 0.26 11.3 24.4 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein C2 PF00168.30 ETO16376.1 - 3.4e-08 33.7 0.3 1.1e-07 32.1 0.1 1.9 2 0 0 2 2 2 1 C2 domain Exo_endo_phos PF03372.23 ETO16377.1 - 2.3e-08 33.9 0.0 6.7e-08 32.3 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Peptidase_C97 PF05903.14 ETO16378.1 - 5e-14 52.4 0.8 9.1e-14 51.5 0.8 1.4 1 0 0 1 1 1 1 PPPDE putative peptidase domain LRR_4 PF12799.7 ETO16379.1 - 7.1e-18 64.4 63.3 6.1e-05 23.3 3.8 7.9 4 3 2 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO16379.1 - 1.2e-14 53.7 53.6 1.3e-05 24.9 6.8 7.0 4 1 2 6 6 6 6 Leucine rich repeat LRR_9 PF14580.6 ETO16379.1 - 3.4e-14 52.7 34.3 5.4e-07 29.3 0.4 4.1 3 1 1 4 4 4 3 Leucine-rich repeat LRR_3 PF07725.12 ETO16379.1 - 1.4 8.9 0.0 1.4 8.9 0.0 5.0 5 0 0 5 5 5 0 Leucine Rich Repeat CSTF2_hinge PF14327.6 ETO16379.1 - 4.7 7.7 6.8 5.4 7.6 0.2 3.4 3 1 0 3 3 3 0 Hinge domain of cleavage stimulation factor subunit 2 YPEB PF14620.6 ETO16380.1 - 0.0064 15.9 0.9 0.0075 15.7 0.9 1.0 1 0 0 1 1 1 1 YpeB sporulation NUC PF18510.1 ETO16380.1 - 0.0095 16.4 0.5 0.0095 16.4 0.5 1.9 1 1 1 2 2 2 1 Nuclease domain DUF4845 PF16137.5 ETO16380.1 - 0.14 13.0 3.5 0.29 12.0 3.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4845) HR1 PF02185.16 ETO16380.1 - 0.53 10.4 5.3 2.1 8.5 5.3 1.8 1 1 0 1 1 1 0 Hr1 repeat Beta-lactamase PF00144.24 ETO16381.1 - 1.5e-11 44.1 0.1 2e-11 43.7 0.1 1.1 1 0 0 1 1 1 1 Beta-lactamase Ank_4 PF13637.6 ETO16383.1 - 0.0084 16.7 0.6 0.097 13.3 0.2 3.0 3 1 0 3 3 3 1 Ankyrin repeats (many copies) CBM_20 PF00686.19 ETO16383.1 - 0.029 14.3 0.4 0.072 13.0 0.4 1.6 1 0 0 1 1 1 0 Starch binding domain DUF1409 PF07197.12 ETO16383.1 - 0.061 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1409) NADPH_Ox PF08414.10 ETO16383.1 - 0.15 12.4 0.5 1.4 9.3 0.4 2.5 2 1 1 3 3 3 0 Respiratory burst NADPH oxidase HSDR_N_2 PF13588.6 ETO16384.1 - 0.081 12.9 1.5 0.19 11.7 1.0 1.8 1 1 1 2 2 2 0 Type I restriction enzyme R protein N terminus (HSDR_N) EF-hand_1 PF00036.32 ETO16386.1 - 3.5e-32 107.5 27.4 5.1e-09 35.1 1.0 4.8 4 1 1 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETO16386.1 - 2.5e-26 91.9 16.1 9.3e-14 51.6 3.9 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO16386.1 - 1.7e-24 84.1 24.6 1.1e-08 34.1 1.6 5.3 4 1 1 5 5 5 4 EF hand EF-hand_6 PF13405.6 ETO16386.1 - 6.3e-23 78.7 20.8 2.7e-07 30.0 0.6 5.3 4 2 2 6 6 6 4 EF-hand domain EF-hand_8 PF13833.6 ETO16386.1 - 1.2e-21 76.3 19.7 2.6e-14 52.8 4.8 3.3 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_9 PF14658.6 ETO16386.1 - 3.4e-12 46.5 1.8 1.4e-05 25.3 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO16386.1 - 3.8e-08 33.6 4.3 0.0013 19.0 0.1 2.4 2 1 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO16386.1 - 9.6e-08 31.9 11.0 0.00044 20.2 0.6 3.2 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 ETO16386.1 - 5.3e-05 23.5 2.4 0.017 15.4 0.1 2.8 2 1 1 3 3 3 2 EF-hand domain Caleosin PF05042.13 ETO16386.1 - 5.5e-05 23.2 4.1 0.1 12.5 0.0 3.7 1 1 3 4 4 4 2 Caleosin related protein Dockerin_1 PF00404.18 ETO16386.1 - 5.6e-05 23.2 7.6 0.02 15.1 1.7 3.6 1 1 3 4 4 4 3 Dockerin type I domain TerB PF05099.13 ETO16386.1 - 0.00029 20.8 9.4 0.061 13.3 0.0 3.2 3 1 0 3 3 3 2 Tellurite resistance protein TerB EF-hand_11 PF08976.11 ETO16386.1 - 0.00094 20.0 0.1 0.52 11.2 0.0 2.4 1 1 1 2 2 2 1 EF-hand domain SurA_N_2 PF13623.6 ETO16386.1 - 0.0012 18.7 7.3 0.25 11.2 0.8 2.9 1 1 1 2 2 2 2 SurA N-terminal domain DUF1456 PF07308.13 ETO16386.1 - 0.025 14.9 3.9 0.59 10.5 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1456) VbhA PF18495.1 ETO16386.1 - 0.039 13.8 2.0 56 3.7 0.0 4.7 4 2 1 5 5 5 0 Antitoxin VbhA EF-hand_10 PF14788.6 ETO16386.1 - 0.19 11.6 6.2 0.15 12.0 1.0 2.4 2 0 0 2 2 2 0 EF hand ApbA_C PF08546.11 ETO16386.1 - 0.27 11.5 1.7 7.3 6.8 0.0 2.5 3 0 0 3 3 2 0 Ketopantoate reductase PanE/ApbA C terminal DUF4845 PF16137.5 ETO16386.1 - 0.42 11.5 0.0 0.42 11.5 0.0 2.5 3 1 0 3 3 2 0 Domain of unknown function (DUF4845) DUF2666 PF10869.8 ETO16386.1 - 0.52 10.5 4.4 7.4 6.8 0.2 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF2666) DUF3349 PF11829.8 ETO16386.1 - 0.52 11.1 4.4 5.3 7.9 0.1 3.2 2 1 2 4 4 4 0 Protein of unknown function (DUF3349) DUF4629 PF15442.6 ETO16386.1 - 0.92 9.7 10.4 1.4 9.1 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4629) DUF2992 PF11208.8 ETO16386.1 - 3.8 7.8 8.6 2.8 8.2 6.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) VCBS PF13517.6 ETO16386.1 - 5.7 7.6 12.0 22 5.7 0.1 4.1 4 0 0 4 4 4 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella DEK_C PF08766.11 ETO16388.1 - 0.021 14.7 0.0 0.038 13.9 0.0 1.5 1 0 0 1 1 1 0 DEK C terminal domain Shugoshin_C PF07557.11 ETO16389.1 - 0.066 13.0 1.8 0.066 13.0 1.8 1.8 2 0 0 2 2 2 0 Shugoshin C terminus TPR_12 PF13424.6 ETO16390.1 - 2.7e-23 82.1 0.3 2.9e-10 40.3 0.0 2.7 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16390.1 - 4.9e-14 51.5 5.0 7.6e-06 25.5 0.2 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO16390.1 - 6e-14 51.4 0.0 6.9e-07 28.9 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO16390.1 - 5.8e-13 47.9 11.1 1.2e-06 28.2 0.1 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO16390.1 - 1.3e-10 40.5 0.1 0.0015 18.4 0.0 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO16390.1 - 1.4e-08 34.2 2.1 0.0018 18.3 0.0 3.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO16390.1 - 0.0013 19.0 4.7 1.3 9.6 0.1 3.8 3 2 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO16390.1 - 0.0029 17.3 6.3 0.063 13.0 0.5 3.4 3 1 1 4 4 4 1 TPR repeat DUF5113 PF17140.4 ETO16390.1 - 0.0038 17.1 1.1 0.54 10.0 0.2 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETO16390.1 - 0.014 16.1 0.0 0.13 13.0 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat Mob_Pre PF01076.19 ETO16390.1 - 0.048 13.5 4.9 1.5 8.6 0.6 2.2 2 0 0 2 2 2 0 Plasmid recombination enzyme Fis1_TPR_C PF14853.6 ETO16390.1 - 0.049 13.7 0.4 4.4 7.5 0.1 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_14 PF13428.6 ETO16390.1 - 0.055 14.3 0.0 3.1 8.9 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF241 PF03087.14 ETO16390.1 - 0.061 13.1 0.2 0.091 12.6 0.2 1.2 1 0 0 1 1 1 0 Arabidopsis protein of unknown function Holin_BhlA PF10960.8 ETO16391.1 - 0.056 13.4 0.1 0.088 12.8 0.1 1.3 1 0 0 1 1 1 0 BhlA holin family OAD_gamma PF04277.13 ETO16391.1 - 0.09 13.4 0.0 0.13 12.9 0.0 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain CDV3 PF15359.6 ETO16392.1 - 0.017 15.6 12.1 0.15 12.6 0.4 2.6 2 1 0 2 2 2 0 Carnitine deficiency-associated protein 3 CAC1F_C PF16885.5 ETO16392.1 - 0.048 13.3 7.3 0.061 13.0 7.3 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Bac_rhamnosid_C PF17390.2 ETO16392.1 - 0.54 10.1 5.9 0.27 11.1 0.4 2.9 2 1 1 3 3 3 0 Bacterial alpha-L-rhamnosidase C-terminal domain Hexapep PF00132.24 ETO16393.1 - 0.35 10.7 2.1 0.45 10.3 0.3 2.1 2 0 0 2 2 2 0 Bacterial transferase hexapeptide (six repeats) Thiolase_N PF00108.23 ETO16394.1 - 1.5e-57 195.0 9.5 1.1e-44 152.8 1.6 4.1 3 1 1 4 4 4 4 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETO16394.1 - 4.8e-39 132.8 0.4 4.8e-39 132.8 0.4 2.3 3 0 0 3 3 3 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ETO16394.1 - 6.4e-07 29.2 4.8 1e-05 25.2 1.0 3.2 3 1 1 4 4 4 1 Beta-ketoacyl synthase, N-terminal domain Ion_trans PF00520.31 ETO16395.1 - 3.8e-51 173.7 26.9 3.4e-37 128.0 19.1 3.1 2 1 0 2 2 2 2 Ion transport protein MAP17 PF15807.5 ETO16395.1 - 0.046 14.0 0.1 0.094 12.9 0.1 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Lustrin_cystein PF14625.6 ETO16395.1 - 0.071 13.5 0.7 0.21 12.0 0.7 1.8 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain DUF4834 PF16118.5 ETO16395.1 - 0.53 11.3 2.4 1.6 9.7 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) POLO_box PF00659.18 ETO16396.1 - 5.2e-30 103.4 2.5 4.4e-17 62.0 0.0 2.5 2 0 0 2 2 2 2 POLO box duplicated region Sterile PF03015.19 ETO16396.1 - 0.11 12.8 2.3 0.24 11.6 2.3 1.6 1 0 0 1 1 1 0 Male sterility protein DUF4279 PF14106.6 ETO16397.1 - 0.013 15.7 0.5 0.14 12.3 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) DUF640 PF04852.12 ETO16397.1 - 0.034 14.3 0.2 0.054 13.7 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF640) PAP_assoc PF03828.19 ETO16398.1 - 1.1e-09 38.3 1.8 6.5e-09 35.9 1.8 2.3 2 0 0 2 2 2 1 Cid1 family poly A polymerase DUF4834 PF16118.5 ETO16398.1 - 0.027 15.4 4.4 0.12 13.4 4.4 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Zip PF02535.22 ETO16398.1 - 0.029 13.6 1.9 0.053 12.7 1.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter HCO3_cotransp PF00955.21 ETO16398.1 - 0.064 12.1 4.6 0.12 11.1 4.6 1.4 1 0 0 1 1 1 0 HCO3- transporter family Presenilin PF01080.17 ETO16398.1 - 0.13 11.0 4.8 0.25 10.1 4.8 1.4 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.5 ETO16398.1 - 0.36 9.7 7.2 0.42 9.5 6.3 1.6 1 1 0 1 1 1 0 Ceramide synthase regulator Utp14 PF04615.13 ETO16398.1 - 0.42 9.1 7.6 2.2 6.7 4.5 2.0 2 0 0 2 2 2 0 Utp14 protein MID_MedPIWI PF18296.1 ETO16398.1 - 0.6 9.9 12.4 0.039 13.7 3.9 2.2 2 0 0 2 2 2 0 MID domain of medPIWI MAP70 PF07058.11 ETO16398.1 - 4.2 6.0 15.8 0.29 9.8 4.4 2.1 2 0 0 2 2 2 0 Microtubule-associated protein 70 PRP1_N PF06424.12 ETO16398.1 - 5.6 7.4 12.1 13 6.2 12.1 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal Macoilin PF09726.9 ETO16398.1 - 6.6 5.2 20.5 2.9 6.3 2.5 2.1 2 0 0 2 2 2 0 Macoilin family zf-Mss51 PF13824.6 ETO16399.1 - 1.4 9.1 4.8 1.5 9.0 0.3 3.3 3 1 0 3 3 3 0 Zinc-finger of mitochondrial splicing suppressor 51 2OG-FeII_Oxy_2 PF13532.6 ETO16400.1 - 2.3e-06 27.9 1.1 4.3e-06 27.1 0.2 1.9 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily PWWP PF00855.17 ETO16400.1 - 0.46 10.9 2.8 1.1 9.7 0.1 2.7 2 1 1 3 3 3 0 PWWP domain Spc7 PF08317.11 ETO16401.1 - 0.00072 18.5 21.1 0.00072 18.5 21.1 2.1 1 1 0 2 2 2 1 Spc7 kinetochore protein Cob_adeno_trans PF01923.18 ETO16401.1 - 1.5 9.0 9.9 1.4 9.1 7.5 2.2 1 1 1 2 2 2 0 Cobalamin adenosyltransferase ATG16 PF08614.11 ETO16401.1 - 2 8.6 31.5 0.41 10.8 15.6 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) WDCP PF15390.6 ETO16401.1 - 3.7 5.8 12.9 5.1 5.3 12.9 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family V_ATPase_I PF01496.19 ETO16401.1 - 4.8 5.0 24.0 10 3.9 20.1 1.9 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family DUF3573 PF12097.8 ETO16401.1 - 8.3 5.1 8.6 12 4.6 8.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) XhlA PF10779.9 ETO16401.1 - 9.1 6.6 13.9 26 5.1 5.9 3.3 2 1 1 3 3 3 0 Haemolysin XhlA Spc29 PF17082.5 ETO16402.1 - 0.018 14.9 7.5 0.018 14.9 7.5 3.5 2 2 1 3 3 3 0 Spindle Pole Component 29 RPW8 PF05659.11 ETO16402.1 - 0.032 13.9 0.9 0.032 13.9 0.9 2.7 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Pox_A_type_inc PF04508.12 ETO16402.1 - 0.058 13.3 1.7 0.25 11.3 1.7 2.2 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat CALCOCO1 PF07888.11 ETO16402.1 - 0.082 11.8 34.7 0.12 11.2 34.2 1.5 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like LMBR1 PF04791.16 ETO16402.1 - 0.27 10.1 18.5 0.48 9.3 18.5 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein XhlA PF10779.9 ETO16402.1 - 0.44 10.8 17.2 1.9 8.7 2.9 3.6 3 0 0 3 3 3 0 Haemolysin XhlA KRAB PF01352.27 ETO16402.1 - 0.66 9.7 2.6 0.91 9.2 0.4 2.4 2 0 0 2 2 2 0 KRAB box PKcGMP_CC PF16808.5 ETO16402.1 - 1.1 9.2 10.3 1.6 8.6 1.2 3.0 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 ETO16402.1 - 1.9 8.8 32.7 2.6 8.4 12.6 3.7 2 1 2 4 4 4 0 Plant protein of unknown function (DUF641) DUF948 PF06103.11 ETO16402.1 - 2.2 8.6 6.1 4.5 7.6 0.3 2.6 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HOOK PF05622.12 ETO16402.1 - 2.4 6.2 41.0 5.4 5.0 36.3 2.7 1 1 0 2 2 2 0 HOOK protein DUF730 PF05325.11 ETO16402.1 - 2.7 8.0 5.6 11 6.1 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF730) MutS_IV PF05190.18 ETO16402.1 - 4 7.8 18.7 3.2 8.1 1.4 4.1 2 1 2 4 4 4 0 MutS family domain IV DUF1664 PF07889.12 ETO16402.1 - 4.3 7.4 24.5 0.89 9.6 5.7 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) GAS PF13851.6 ETO16402.1 - 4.7 6.5 47.2 15 4.9 1.0 3.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 ETO16402.1 - 6.4 6.9 38.0 0.13 12.3 5.9 4.1 3 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding FUSC PF04632.12 ETO16402.1 - 9.6 4.6 9.9 22 3.4 9.9 1.7 1 0 0 1 1 1 0 Fusaric acid resistance protein family LisH_TPL PF17814.1 ETO16405.1 - 1.6e-11 43.6 1.0 4.3e-11 42.3 1.0 1.8 1 0 0 1 1 1 1 LisH-like dimerisation domain WD40 PF00400.32 ETO16405.1 - 5.5e-10 39.7 0.2 8.2e-05 23.3 0.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16405.1 - 6.4e-08 32.8 0.0 0.0048 17.2 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16405.1 - 4.6e-05 22.5 0.0 0.006 15.6 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein GerA PF03323.13 ETO16405.1 - 0.087 11.3 0.1 0.32 9.4 0.0 1.9 2 0 0 2 2 2 0 Bacillus/Clostridium GerA spore germination protein SAS4 PF15460.6 ETO16405.1 - 0.2 11.8 3.3 9.1 6.4 0.5 2.5 2 0 0 2 2 2 0 Something about silencing, SAS, complex subunit 4 WD40 PF00400.32 ETO16406.1 - 1.7e-08 35.0 5.2 1.4e-06 28.9 0.1 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16406.1 - 0.006 16.9 0.2 0.88 9.9 0.0 3.4 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain MFP2b PF12150.8 ETO16406.1 - 0.049 12.9 0.0 0.092 12.0 0.0 1.4 1 0 0 1 1 1 0 Cytosolic motility protein DUF4293 PF14126.6 ETO16406.1 - 0.11 12.8 1.3 0.24 11.6 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) DUF334 PF03904.13 ETO16407.1 - 0.042 13.4 0.8 0.054 13.0 0.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF334) Spc7 PF08317.11 ETO16407.1 - 0.058 12.3 3.1 0.068 12.0 3.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Imm70 PF15601.6 ETO16407.1 - 0.1 12.1 0.1 0.13 11.8 0.1 1.3 1 0 0 1 1 1 0 Immunity protein 70 Fib_alpha PF08702.10 ETO16407.1 - 0.11 12.7 5.6 0.3 11.2 5.6 1.7 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family BLOC1_2 PF10046.9 ETO16407.1 - 0.21 11.9 6.0 1.2 9.5 1.0 2.1 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YlbD_coat PF14071.6 ETO16407.1 - 0.35 11.1 3.7 0.51 10.6 3.7 1.2 1 0 0 1 1 1 0 Putative coat protein Sad1_UNC PF07738.13 ETO16408.1 - 2.4e-10 40.5 0.2 7.6e-10 38.9 0.0 1.9 2 1 0 2 2 2 1 Sad1 / UNC-like C-terminal CALCOCO1 PF07888.11 ETO16408.1 - 0.0056 15.6 7.4 0.0062 15.5 7.4 1.0 1 0 0 1 1 1 1 Calcium binding and coiled-coil domain (CALCOCO1) like YlbD_coat PF14071.6 ETO16408.1 - 0.0057 16.9 9.2 0.14 12.4 5.0 3.0 2 1 1 3 3 3 1 Putative coat protein Tropomyosin_1 PF12718.7 ETO16408.1 - 0.011 15.9 7.3 0.011 15.9 7.3 1.7 2 0 0 2 2 2 0 Tropomyosin like DUF3287 PF11690.8 ETO16408.1 - 0.21 11.3 2.4 6.1 6.6 1.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3287) YabA PF06156.13 ETO16408.1 - 1.3 9.8 7.2 2.6 8.7 3.6 2.4 1 1 1 2 2 2 0 Initiation control protein YabA DUF1664 PF07889.12 ETO16408.1 - 1.5 8.9 5.4 1.9 8.6 2.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CENP-Q PF13094.6 ETO16408.1 - 2 8.6 8.6 2.2 8.5 7.7 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit EMP24_GP25L PF01105.24 ETO16408.1 - 3.8 7.4 9.7 6.4 6.7 0.3 2.2 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Vac_Fusion PF02346.16 ETO16408.1 - 5 6.8 6.4 0.75 9.5 1.1 2.3 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 CCDC53 PF10152.9 ETO16408.1 - 5.4 7.4 8.8 0.41 11.0 0.2 2.2 1 1 1 2 2 2 0 Subunit CCDC53 of WASH complex ABC_tran_CTD PF16326.5 ETO16408.1 - 6.2 7.2 9.2 8 6.8 1.0 3.1 2 1 2 4 4 3 0 ABC transporter C-terminal domain Allexi_40kDa PF05549.11 ETO16408.1 - 6.9 6.1 9.7 4 6.9 4.2 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein BRO1 PF03097.18 ETO16409.1 - 1.2e-19 70.4 1.4 1.7e-19 69.9 1.4 1.2 1 0 0 1 1 1 1 BRO1-like domain HGAL PF15666.5 ETO16411.1 - 2.8 8.1 7.2 0.55 10.4 2.8 2.2 2 1 1 3 3 3 0 Germinal center-associated lymphoma Hira PF07569.11 ETO16412.1 - 2.9e-13 50.1 2.3 9.1e-13 48.4 2.3 1.8 1 1 0 1 1 1 1 TUP1-like enhancer of split DNase_NucA_NucB PF14040.6 ETO16412.1 - 0.12 12.8 1.7 0.43 11.0 1.7 1.9 1 0 0 1 1 1 0 Deoxyribonuclease NucA/NucB DUF5572 PF17733.1 ETO16412.1 - 0.12 12.2 0.5 6.2 6.7 0.0 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5572) Methyltransf_31 PF13847.6 ETO16413.1 - 2.9e-19 69.3 0.0 4.1e-19 68.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO16413.1 - 4e-19 69.1 0.0 1.6e-18 67.1 0.0 2.0 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO16413.1 - 9.5e-18 64.7 0.0 2.4e-17 63.4 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO16413.1 - 1.7e-16 60.5 0.0 2.7e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETO16413.1 - 1e-13 51.3 0.0 2.3e-13 50.1 0.0 1.6 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 ETO16413.1 - 9.1e-12 45.6 0.0 3e-11 43.9 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO16413.1 - 8.5e-10 38.4 0.0 2.8e-09 36.6 0.0 1.7 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family PCMT PF01135.19 ETO16413.1 - 4.3e-08 33.2 0.0 7.5e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) MTS PF05175.14 ETO16413.1 - 2.8e-06 27.0 0.0 6.7e-06 25.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_15 PF09445.10 ETO16413.1 - 1e-05 25.2 0.0 1.5e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_2 PF00891.18 ETO16413.1 - 0.00014 21.2 0.0 0.00023 20.5 0.0 1.3 1 0 0 1 1 1 1 O-methyltransferase domain Methyltransf_32 PF13679.6 ETO16413.1 - 0.0002 21.4 0.0 0.00035 20.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ETO16413.1 - 0.00024 20.8 0.0 0.00079 19.1 0.0 1.8 2 0 0 2 2 2 1 Methionine biosynthesis protein MetW PrmA PF06325.13 ETO16413.1 - 0.00038 19.9 0.0 0.00068 19.1 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 ETO16413.1 - 0.0021 17.7 0.0 0.0037 16.8 0.0 1.4 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_9 PF08003.11 ETO16413.1 - 0.0021 17.1 0.0 0.0035 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) CheR PF01739.18 ETO16413.1 - 0.0023 17.5 0.1 0.17 11.3 0.0 2.7 1 1 1 2 2 2 1 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.17 ETO16413.1 - 0.0052 16.3 0.0 0.1 12.1 0.0 2.5 2 1 1 3 3 3 1 Putative methyltransferase TehB PF03848.14 ETO16413.1 - 0.022 14.2 0.0 0.032 13.7 0.0 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Methyltransf_18 PF12847.7 ETO16413.1 - 0.044 13.7 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain ADH_zinc_N PF00107.26 ETO16413.1 - 0.071 13.1 0.0 0.7 9.9 0.0 2.2 1 1 0 1 1 1 0 Zinc-binding dehydrogenase Methyltransf_3 PF01596.17 ETO16413.1 - 0.1 11.7 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 O-methyltransferase WD40 PF00400.32 ETO16414.1 - 5.1e-50 166.4 5.7 9.1e-10 39.0 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16414.1 - 2.2e-16 59.9 3.4 0.011 16.0 0.0 4.9 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16414.1 - 5.8e-11 41.9 1.0 0.00071 18.6 0.1 5.0 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16414.1 - 2.5e-09 37.3 0.8 0.00095 19.1 0.1 2.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO16414.1 - 1.1e-08 34.8 1.7 1.3 9.0 0.1 6.2 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO16414.1 - 4.4e-07 28.9 1.1 0.021 13.5 0.1 3.7 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO16414.1 - 0.0007 18.2 0.1 0.009 14.6 0.1 2.3 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO16414.1 - 0.00089 18.7 3.6 0.095 12.0 0.1 3.5 2 1 2 4 4 4 3 WD40-like domain DUF2214 PF09980.9 ETO16414.1 - 0.03 14.1 0.1 0.054 13.3 0.1 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2214) DUF5570 PF17731.1 ETO16414.1 - 0.036 14.2 0.4 18 5.5 0.0 3.1 2 1 1 3 3 3 0 Family of unknown function (DUF5570) SBD PF17882.1 ETO16414.1 - 0.076 12.8 1.6 4.2 7.2 0.0 3.4 3 1 1 4 4 4 0 OAA-family lectin sugar binding domain PALB2_WD40 PF16756.5 ETO16414.1 - 0.2 10.5 5.7 1 8.2 0.0 3.5 2 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF4423 PF14394.6 ETO16415.1 - 0.0073 16.0 0.7 0.013 15.3 0.7 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4423) Mss4 PF04421.13 ETO16415.1 - 0.16 12.1 6.2 0.3 11.2 1.0 2.5 2 0 0 2 2 2 0 Mss4 protein PhyH PF05721.13 ETO16416.1 - 1.9e-16 61.0 0.0 3.3e-16 60.2 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DLH PF01738.18 ETO16417.1 - 2.6e-14 53.3 0.0 9.2e-14 51.5 0.0 1.8 1 1 0 1 1 1 1 Dienelactone hydrolase family BRCT_2 PF16589.5 ETO16418.1 - 0.0016 18.8 0.1 0.013 15.9 0.0 2.1 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ETO16418.1 - 0.047 13.6 0.2 3.1 7.7 0.0 2.5 3 0 0 3 3 3 0 Regulator of Ty1 transposition protein 107 BRCT domain Exo_endo_phos_2 PF14529.6 ETO16419.1 - 2.1e-14 53.4 0.1 5.2e-14 52.1 0.1 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase DUF2877 PF11392.8 ETO16420.1 - 0.12 13.1 0.1 0.3 11.8 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2877) SPRY PF00622.28 ETO16421.1 - 1.5e-21 76.8 2.9 1e-11 45.0 0.8 2.5 2 0 0 2 2 2 2 SPRY domain Neuralized PF07177.12 ETO16421.1 - 0.0019 18.2 0.1 0.33 11.0 0.0 2.4 2 0 0 2 2 2 2 Neuralized DUF4982 PF16355.5 ETO16421.1 - 0.019 14.9 0.1 2.7 8.0 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4982) Sad1_UNC PF07738.13 ETO16421.1 - 0.058 13.4 2.8 4.3 7.4 0.2 2.7 3 0 0 3 3 3 0 Sad1 / UNC-like C-terminal Bunya_NS-S PF01104.17 ETO16421.1 - 0.07 13.0 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Bunyavirus non-structural protein NS-s DUF4358 PF14270.6 ETO16422.1 - 0.0061 16.8 0.0 0.0061 16.8 0.0 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4358) PH PF00169.29 ETO16422.1 - 0.025 15.1 0.3 0.025 15.1 0.3 3.6 5 0 0 5 5 5 0 PH domain MutL_C PF08676.11 ETO16422.1 - 0.19 11.5 1.5 0.69 9.7 0.3 2.3 2 0 0 2 2 2 0 MutL C terminal dimerisation domain GATase PF00117.28 ETO16423.1 - 2.3e-21 76.4 0.0 3.7e-21 75.7 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I CPSase_sm_chain PF00988.22 ETO16423.1 - 1.2e-19 70.4 0.0 3.8e-19 68.8 0.0 1.8 2 0 0 2 2 2 1 Carbamoyl-phosphate synthase small chain, CPSase domain Peptidase_C26 PF07722.13 ETO16423.1 - 0.0059 16.4 0.0 0.0092 15.7 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 DUF997 PF06196.12 ETO16423.1 - 0.023 14.7 0.0 0.054 13.5 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF997) DUF5094 PF17015.5 ETO16423.1 - 0.056 13.5 0.3 0.088 12.9 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) GATase PF00117.28 ETO16424.1 - 9.5e-18 64.6 0.0 1.2e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Glutamine amidotransferase class-I TPR_MLP1_2 PF07926.12 ETO16425.1 - 0.019 15.0 11.3 0.019 15.0 11.3 5.7 3 3 0 4 4 4 0 TPR/MLP1/MLP2-like protein Kelch_6 PF13964.6 ETO16427.1 - 0.0056 16.9 0.5 1.1 9.6 0.0 3.1 3 0 0 3 3 3 2 Kelch motif Ras PF00071.22 ETO16428.1 - 4.1e-08 33.0 0.0 6e-08 32.5 0.0 1.2 1 0 0 1 1 1 1 Ras family Malt_amylase_C PF16657.5 ETO16428.1 - 0.11 12.6 0.0 23 5.2 0.0 2.4 2 0 0 2 2 2 0 Maltogenic Amylase, C-terminal domain WD40 PF00400.32 ETO16429.1 - 0.00032 21.5 1.4 0.0022 18.8 0.0 2.6 2 1 0 2 2 2 1 WD domain, G-beta repeat TLD PF07534.16 ETO16430.1 - 6.1e-09 36.2 1.6 3.1e-08 33.9 0.1 2.8 2 0 0 2 2 2 1 TLD Geminin PF07412.12 ETO16431.1 - 0.00051 19.8 6.6 0.00088 19.1 6.6 1.3 1 0 0 1 1 1 1 Geminin SIKE PF05769.11 ETO16431.1 - 0.0009 19.2 2.7 0.0009 19.2 2.7 1.9 2 0 0 2 2 2 1 SIKE family DivIC PF04977.15 ETO16431.1 - 0.00099 18.8 2.7 0.00099 18.8 2.7 2.4 2 1 1 3 3 3 2 Septum formation initiator UPF0242 PF06785.11 ETO16431.1 - 0.002 18.3 4.1 0.0022 18.1 4.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF2681 PF10883.8 ETO16431.1 - 0.66 10.4 9.3 0.051 14.0 3.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) PigN PF04987.14 ETO16431.1 - 0.96 8.2 3.6 0.58 9.0 0.5 1.8 1 1 1 2 2 2 0 Phosphatidylinositolglycan class N (PIG-N) TSC22 PF01166.18 ETO16431.1 - 1.9 8.9 10.5 0.85 10.0 1.8 2.9 2 1 1 3 3 3 0 TSC-22/dip/bun family NYD-SP28_assoc PF14775.6 ETO16431.1 - 2.1 8.5 11.9 0.8 9.8 3.6 2.4 1 1 1 2 2 2 0 Sperm tail C-terminal domain bZIP_2 PF07716.15 ETO16431.1 - 5.2 7.2 13.5 1.6 8.9 1.6 2.7 3 0 0 3 3 3 0 Basic region leucine zipper FAM167 PF11652.8 ETO16432.1 - 0.024 15.1 0.3 0.05 14.1 0.1 1.6 2 0 0 2 2 2 0 FAM167 Coilin_N PF15862.5 ETO16433.1 - 0.055 13.3 9.4 0.054 13.3 9.4 1.2 1 0 0 1 1 1 0 Coilin N-terminus CDC45 PF02724.14 ETO16433.1 - 0.083 11.2 11.4 0.077 11.3 11.4 1.0 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO16433.1 - 0.095 13.1 8.4 0.097 13.1 8.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 ETO16433.1 - 0.19 11.6 11.9 0.17 11.7 11.9 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO16433.1 - 0.32 9.7 8.2 0.31 9.8 8.2 1.1 1 0 0 1 1 1 0 Presenilin Atrophin-1 PF03154.15 ETO16433.1 - 0.6 8.3 11.4 0.6 8.3 11.4 1.2 1 0 0 1 1 1 0 Atrophin-1 family Hid1 PF12722.7 ETO16433.1 - 0.8 7.8 7.7 0.72 7.9 7.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TMEM214 PF10151.9 ETO16433.1 - 0.85 8.0 7.7 0.77 8.1 7.7 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator EOS1 PF12326.8 ETO16433.1 - 0.88 9.5 2.5 0.83 9.6 2.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein CobT PF06213.12 ETO16433.1 - 0.92 8.9 17.2 1 8.7 17.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DDHD PF02862.17 ETO16433.1 - 1 9.5 5.3 1.1 9.4 5.3 1.1 1 0 0 1 1 1 0 DDHD domain Serinc PF03348.15 ETO16433.1 - 1.3 7.9 3.0 1.1 8.1 3.0 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_polI_A34 PF08208.11 ETO16433.1 - 1.5 8.9 21.0 2 8.5 21.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NARP1 PF12569.8 ETO16433.1 - 3.1 6.6 15.4 3.5 6.4 15.4 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Connexin PF00029.19 ETO16433.1 - 3.3 7.4 10.3 3.9 7.2 10.3 1.1 1 0 0 1 1 1 0 Connexin PPL5 PF18168.1 ETO16433.1 - 3.6 6.8 10.7 4.1 6.6 10.7 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF2828 PF11443.8 ETO16433.1 - 3.6 5.6 11.9 4.1 5.4 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3292 PF11696.8 ETO16433.1 - 6.4 5.0 10.2 6.8 4.9 10.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) CLN3 PF02487.17 ETO16433.1 - 9.6 5.1 5.8 10 5.0 5.8 1.1 1 0 0 1 1 1 0 CLN3 protein GIT_CC PF16559.5 ETO16434.1 - 0.021 14.7 8.6 0.021 14.7 8.6 4.0 3 1 1 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMIE PF16038.5 ETO16434.1 - 0.024 14.5 0.7 0.024 14.5 0.7 3.2 1 1 3 4 4 4 0 TMIE protein DUF1816 PF08846.10 ETO16434.1 - 0.13 12.3 0.0 0.47 10.5 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1816) Poty_PP PF08440.10 ETO16434.1 - 0.15 11.1 14.5 0.25 10.4 14.5 1.3 1 0 0 1 1 1 0 Potyviridae polyprotein DUF4618 PF15397.6 ETO16434.1 - 0.19 11.1 29.4 0.25 10.7 29.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) Exonuc_VII_L PF02601.15 ETO16434.1 - 0.22 11.1 18.8 0.32 10.5 18.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM184 PF15665.5 ETO16434.1 - 0.37 10.5 31.8 0.48 10.2 5.3 2.4 1 1 1 2 2 2 0 Family with sequence similarity 184, A and B FUSC PF04632.12 ETO16434.1 - 0.39 9.2 3.4 0.45 9.0 3.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family GAS PF13851.6 ETO16434.1 - 0.42 9.9 36.1 0.17 11.2 22.8 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding SHE3 PF17078.5 ETO16434.1 - 0.67 9.6 28.3 1.3 8.7 27.6 1.6 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Globin PF00042.22 ETO16434.1 - 0.76 10.4 7.1 0.73 10.4 1.2 2.6 1 1 2 3 3 3 0 Globin AIP3 PF03915.13 ETO16434.1 - 0.8 8.7 27.7 0.022 13.9 17.0 2.0 1 1 1 2 2 2 0 Actin interacting protein 3 Uso1_p115_C PF04871.13 ETO16434.1 - 1.4 9.3 35.2 2.2 8.7 30.2 2.8 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Ax_dynein_light PF10211.9 ETO16434.1 - 2.4 8.1 33.9 5.9 6.8 17.2 2.8 1 1 1 2 2 2 0 Axonemal dynein light chain Cep57_CLD_2 PF14197.6 ETO16434.1 - 4.4 7.5 32.9 2.2 8.4 8.2 4.4 2 1 2 4 4 4 0 Centrosome localisation domain of PPC89 DUF2937 PF11157.8 ETO16434.1 - 5 6.8 10.5 1.5 8.5 4.5 2.4 2 2 0 2 2 2 0 Protein of unknown function (DUF2937) LMBR1 PF04791.16 ETO16434.1 - 5.8 5.7 13.4 6.9 5.4 13.4 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein FPP PF05911.11 ETO16435.1 - 0.0004 18.7 22.0 0.00043 18.6 22.0 1.0 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil FHIPEP PF00771.20 ETO16435.1 - 0.0091 14.5 3.2 0.012 14.2 3.2 1.1 1 0 0 1 1 1 1 FHIPEP family Tropomyosin_1 PF12718.7 ETO16435.1 - 0.01 16.0 21.5 0.01 16.0 21.5 2.0 1 1 1 2 2 2 0 Tropomyosin like Tmemb_cc2 PF10267.9 ETO16435.1 - 0.016 14.4 17.0 0.024 13.8 17.0 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein PKcGMP_CC PF16808.5 ETO16435.1 - 0.033 14.0 2.7 0.033 14.0 2.7 2.9 3 1 0 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Glu-tRNAGln PF02686.15 ETO16435.1 - 0.037 14.3 0.4 0.037 14.3 0.4 2.1 2 1 0 2 2 1 0 Glu-tRNAGln amidotransferase C subunit CCDC144C PF14915.6 ETO16435.1 - 0.054 12.6 25.1 0.19 10.8 25.1 1.8 1 1 0 1 1 1 0 CCDC144C protein coiled-coil region APC_N_CC PF16689.5 ETO16435.1 - 0.065 13.3 1.7 0.065 13.3 1.7 3.5 2 1 1 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain Nup88 PF10168.9 ETO16435.1 - 0.07 10.9 10.9 0.079 10.8 10.9 1.2 1 0 0 1 1 1 0 Nuclear pore component XhlA PF10779.9 ETO16435.1 - 0.084 13.1 0.9 0.084 13.1 0.9 3.2 3 1 1 4 4 3 0 Haemolysin XhlA Rho_Binding PF08912.11 ETO16435.1 - 0.19 12.5 26.0 0.22 12.4 5.4 3.2 2 1 1 3 3 3 0 Rho Binding Exonuc_VII_L PF02601.15 ETO16435.1 - 0.2 11.2 17.4 0.29 10.7 17.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Golgin_A5 PF09787.9 ETO16435.1 - 0.2 11.1 23.8 2 7.8 23.8 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 5 Rootletin PF15035.6 ETO16435.1 - 0.25 11.4 32.0 0.039 14.0 10.9 2.9 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF1664 PF07889.12 ETO16435.1 - 0.3 11.1 12.5 0.072 13.1 6.7 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ETO16435.1 - 0.31 10.3 12.4 0.47 9.7 12.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Bacillus_HBL PF05791.11 ETO16435.1 - 0.53 10.1 12.4 0.45 10.3 9.1 2.4 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) CENP-F_leu_zip PF10473.9 ETO16435.1 - 0.63 10.1 28.9 0.058 13.4 20.8 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PEARLI-4 PF05278.12 ETO16435.1 - 1.1 8.7 12.1 0.13 11.8 7.1 1.9 1 1 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) LPP PF04728.13 ETO16435.1 - 1.3 9.4 11.1 3.2 8.2 0.6 3.2 3 1 0 3 3 3 0 Lipoprotein leucine-zipper DUF724 PF05266.14 ETO16435.1 - 1.7 8.4 17.4 2.5 7.9 6.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) MCC-bdg_PDZ PF10506.9 ETO16435.1 - 2 8.5 18.4 0.31 11.1 2.0 3.4 3 1 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome FlaC_arch PF05377.11 ETO16435.1 - 2.1 8.8 17.5 0.09 13.2 2.2 4.0 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) DUF641 PF04859.12 ETO16435.1 - 2.4 8.5 17.8 0.078 13.3 9.2 2.5 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) ADIP PF11559.8 ETO16435.1 - 2.7 8.1 28.3 0.098 12.7 10.0 2.7 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding FapA PF03961.13 ETO16435.1 - 3.3 6.2 14.2 0.71 8.4 11.0 1.5 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4164 PF13747.6 ETO16435.1 - 3.4 8.0 15.7 0.82 10.0 4.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF4140 PF13600.6 ETO16435.1 - 3.4 8.2 13.0 4.6 7.8 1.5 2.7 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc7 PF08317.11 ETO16435.1 - 3.7 6.3 25.3 0.18 10.6 17.9 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4446 PF14584.6 ETO16435.1 - 3.9 7.4 10.7 1.8 8.5 2.2 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) SecD-TM1 PF13721.6 ETO16435.1 - 4 7.9 7.1 0.86 10.1 1.0 2.6 2 1 2 4 4 3 0 SecD export protein N-terminal TM region SlyX PF04102.12 ETO16435.1 - 4.2 8.0 21.0 6.3 7.5 5.3 3.6 2 1 1 3 3 3 0 SlyX Jnk-SapK_ap_N PF09744.9 ETO16435.1 - 4.6 7.4 29.4 0.2 11.9 20.4 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 BLOC1_2 PF10046.9 ETO16435.1 - 7.4 6.9 15.9 0.68 10.3 6.0 3.0 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Laminin_II PF06009.12 ETO16435.1 - 7.7 6.5 16.5 1.2 9.2 4.5 2.7 1 1 1 3 3 3 0 Laminin Domain II Bcr-Abl_Oligo PF09036.10 ETO16435.1 - 8.5 6.5 8.5 12 5.9 0.4 2.7 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain V_ATPase_I PF01496.19 ETO16435.1 - 8.6 4.1 15.2 0.85 7.5 9.9 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family KfrA_N PF11740.8 ETO16435.1 - 8.9 7.0 11.8 3.8 8.2 3.5 2.6 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term NPV_P10 PF05531.12 ETO16435.1 - 10 6.7 11.3 56 4.3 6.8 3.2 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Mce4_CUP1 PF11887.8 ETO16436.1 - 0.036 13.5 8.3 0.23 10.9 1.3 2.7 2 1 1 3 3 3 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF1048 PF06304.11 ETO16436.1 - 0.43 11.1 6.7 0.89 10.0 0.2 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1048) Cas6_N PF17952.1 ETO16436.1 - 2.1 8.7 6.3 0.47 10.7 0.8 2.6 2 1 0 2 2 2 0 Cas6 N-terminal domain Metallophos PF00149.28 ETO16437.1 - 7.2e-20 72.4 0.0 8.6e-20 72.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase WWE PF02825.20 ETO16438.1 - 2.6e-08 34.3 0.0 5.9e-08 33.2 0.0 1.6 1 0 0 1 1 1 1 WWE domain POX PF07526.11 ETO16438.1 - 0.0098 16.5 0.9 0.0098 16.5 0.9 2.4 3 1 1 4 4 4 1 Associated with HOX HA2 PF04408.23 ETO16438.1 - 0.14 12.5 1.3 21 5.4 0.1 2.5 2 0 0 2 2 2 0 Helicase associated domain (HA2) EF-hand_1 PF00036.32 ETO16439.1 - 0.00015 21.0 0.7 0.00049 19.4 0.7 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO16439.1 - 0.00061 20.2 1.0 0.023 15.1 0.2 2.9 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO16439.1 - 0.0092 15.8 0.9 0.042 13.8 0.4 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ETO16439.1 - 0.046 13.6 0.5 0.13 12.1 0.5 1.8 1 0 0 1 1 1 0 EF-hand domain pair NaeI PF09126.10 ETO16439.1 - 0.1 11.8 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Restriction endonuclease NaeI IL5 PF02025.15 ETO16439.1 - 0.33 11.3 2.1 1.1 9.6 0.2 2.5 3 0 0 3 3 3 0 Interleukin 5 EF-hand_5 PF13202.6 ETO16439.1 - 0.78 9.4 4.3 0.23 11.0 0.5 2.3 2 0 0 2 2 2 0 EF hand NOP19 PF10863.8 ETO16441.1 - 0.00058 19.7 0.3 0.00086 19.2 0.3 1.3 1 0 0 1 1 1 1 Nucleolar protein 19 DUF2802 PF10975.8 ETO16441.1 - 0.075 13.2 0.2 0.19 11.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2802) DUF2428 PF10350.9 ETO16442.1 - 1e-15 57.8 0.0 1.7e-15 57.1 0.0 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) DUF2428 PF10350.9 ETO16443.1 - 8.2e-23 81.0 0.0 1.3e-22 80.4 0.0 1.3 1 0 0 1 1 1 1 Putative death-receptor fusion protein (DUF2428) H_PPase PF03030.16 ETO16444.1 - 2.4e-75 254.5 19.3 7.9e-44 150.3 2.4 2.0 2 0 0 2 2 2 2 Inorganic H+ pyrophosphatase Kinesin PF00225.23 ETO16446.1 - 2.6e-07 29.9 1.2 4.6e-06 25.8 1.2 2.5 1 1 0 1 1 1 1 Kinesin motor domain PMSR PF01625.21 ETO16448.1 - 1e-20 74.5 8.8 1.7e-20 73.8 8.8 1.4 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase NUC153 PF08159.12 ETO16448.1 - 0.031 14.1 0.1 0.073 12.9 0.1 1.6 1 0 0 1 1 1 0 NUC153 domain Ldl_recept_a PF00057.18 ETO16448.1 - 0.14 12.4 1.0 0.32 11.2 0.2 1.9 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A EF-hand_1 PF00036.32 ETO16449.1 - 6.6e-10 37.8 0.3 5.7e-08 31.8 0.1 3.4 3 0 0 3 3 3 1 EF hand EF-hand_6 PF13405.6 ETO16449.1 - 1.6e-09 36.9 0.1 1.6e-06 27.5 0.1 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 ETO16449.1 - 1.5e-08 35.0 0.6 1.4e-06 28.6 0.3 2.6 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO16449.1 - 1.7e-06 27.2 0.1 4.2e-06 26.0 0.1 1.6 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 ETO16449.1 - 0.00027 20.7 0.1 0.0018 18.1 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair DUF2100 PF09873.9 ETO16449.1 - 0.089 12.6 0.1 0.13 12.1 0.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2100) RVT_1 PF00078.27 ETO16453.1 - 2.8e-16 59.7 0.4 5.8e-16 58.7 0.4 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CBM_26 PF16824.5 ETO16453.1 - 0.054 13.6 0.6 0.11 12.6 0.6 1.5 1 0 0 1 1 1 0 C-terminal carbohydrate-binding module Arm PF00514.23 ETO16456.1 - 1.8e-22 78.6 0.6 3.9e-06 26.7 0.0 4.7 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO16456.1 - 4.7e-06 27.0 0.0 0.02 15.4 0.0 2.6 1 1 0 2 2 2 2 HEAT-like repeat RICTOR_V PF14668.6 ETO16456.1 - 0.0032 17.7 0.0 9.1 6.6 0.0 3.4 2 1 1 3 3 3 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_2 PF13646.6 ETO16456.1 - 0.024 15.0 0.0 0.24 11.8 0.0 2.2 1 1 1 2 2 2 0 HEAT repeats HEAT PF02985.22 ETO16456.1 - 0.044 14.1 0.0 26 5.4 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat BET PF17035.5 ETO16458.1 - 2.1e-07 31.0 0.1 3.9e-07 30.1 0.1 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation DnaJ-X PF14308.6 ETO16458.1 - 0.0033 16.9 0.7 0.0043 16.5 0.7 1.2 1 0 0 1 1 1 1 X-domain of DnaJ-containing DUF4153 PF13687.6 ETO16458.1 - 0.15 11.7 0.6 0.2 11.3 0.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4153) Bromodomain PF00439.25 ETO16459.1 - 4e-25 87.7 0.0 5.2e-25 87.3 0.0 1.1 1 0 0 1 1 1 1 Bromodomain DUF3682 PF12446.8 ETO16460.1 - 0.097 13.2 8.2 0.099 13.1 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) Folate_carrier PF01770.18 ETO16460.1 - 3.8 6.1 3.9 3.6 6.2 3.9 1.0 1 0 0 1 1 1 0 Reduced folate carrier UPF0239 PF06783.11 ETO16460.1 - 5.1 7.3 10.6 6.2 7.1 10.6 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0239) Ras PF00071.22 ETO16462.1 - 1.1e-16 60.9 1.8 1.8e-15 56.9 1.8 2.2 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO16462.1 - 1.3e-07 31.9 0.0 3.5e-07 30.4 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RIO1 PF01163.22 ETO16462.1 - 0.02 14.5 0.2 0.02 14.5 0.2 1.7 2 0 0 2 2 2 0 RIO1 family ECF_trnsprt PF12822.7 ETO16462.1 - 0.082 13.0 5.8 0.47 10.5 2.8 2.2 2 0 0 2 2 2 0 ECF transporter, substrate-specific component SAM_2 PF07647.17 ETO16463.1 - 0.054 13.6 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) BLOC1_2 PF10046.9 ETO16463.1 - 0.065 13.5 4.5 0.065 13.5 2.3 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 RabGAP-TBC PF00566.18 ETO16464.1 - 2.5e-20 73.1 9.2 2.2e-18 66.7 9.2 2.1 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Pkinase_fungal PF17667.1 ETO16465.1 - 3.1e-06 26.2 2.7 4.7e-05 22.3 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 ETO16465.1 - 0.0021 17.4 0.0 0.0031 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kei1 PF08552.11 ETO16465.1 - 0.28 11.0 0.3 0.41 10.5 0.3 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Presenilin PF01080.17 ETO16465.1 - 3.2 6.4 6.4 3.8 6.2 6.4 1.1 1 0 0 1 1 1 0 Presenilin Cyclin PF08613.11 ETO16466.1 - 9.8e-08 32.5 0.0 2e-07 31.5 0.0 1.5 1 0 0 1 1 1 1 Cyclin Cyclin_N PF00134.23 ETO16466.1 - 6.6e-05 22.7 0.1 0.00014 21.6 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain EVI2A PF05399.11 ETO16466.1 - 0.0042 16.7 1.5 0.011 15.4 1.5 1.6 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) WTF PF03303.13 ETO16466.1 - 0.033 13.9 1.6 0.073 12.8 1.6 1.5 1 0 0 1 1 1 0 WTF protein Vac7 PF12751.7 ETO16466.1 - 0.13 11.7 0.3 0.33 10.3 0.0 1.7 2 0 0 2 2 2 0 Vacuolar segregation subunit 7 Orf78 PF06024.12 ETO16466.1 - 1.3 9.4 6.8 0.13 12.6 2.0 1.8 2 0 0 2 2 2 0 Orf78 (ac78) Acyltransferase PF01553.21 ETO16467.1 - 0.00014 21.4 0.0 0.00032 20.3 0.0 1.7 1 1 0 1 1 1 1 Acyltransferase Tk-SP_N-pro PF18237.1 ETO16467.1 - 0.054 13.6 0.3 4.3 7.5 0.1 2.5 2 0 0 2 2 2 0 Tk-SP N-propeptide domain Nop PF01798.18 ETO16468.1 - 1e-49 169.1 0.4 1.6e-49 168.5 0.4 1.2 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Prp31_C PF09785.9 ETO16468.1 - 2.2e-20 73.8 5.6 1.1e-19 71.5 5.6 2.0 1 1 0 1 1 1 1 Prp31 C terminal domain Nop PF01798.18 ETO16469.1 - 3.7e-11 42.9 0.5 6.6e-11 42.1 0.0 1.6 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin DUF3217 PF11506.8 ETO16469.1 - 0.04 13.9 0.0 0.081 12.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3217) RGS PF00615.19 ETO16470.1 - 9.4e-06 25.9 0.2 1.5e-05 25.2 0.2 1.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain SAM_1 PF00536.30 ETO16473.1 - 1.8e-13 50.7 0.3 3.4e-13 49.8 0.3 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO16473.1 - 1.4e-12 47.5 0.2 2.3e-12 46.8 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO16473.1 - 0.083 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain EF-G-binding_N PF07299.11 ETO16474.1 - 0.025 15.1 0.3 0.056 14.0 0.0 1.8 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal STI1 PF17830.1 ETO16474.1 - 0.025 14.5 0.1 0.061 13.3 0.1 1.6 1 0 0 1 1 1 0 STI1 domain Pkinase PF00069.25 ETO16475.1 - 2.6e-38 131.9 0.5 4.3e-38 131.2 0.5 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16475.1 - 1.2e-15 57.5 0.6 3.2e-15 56.1 0.6 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO16475.1 - 0.00081 18.8 0.1 0.0013 18.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family FTA2 PF13095.6 ETO16475.1 - 0.0047 16.6 1.6 0.043 13.5 0.5 2.1 1 1 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 RIO1 PF01163.22 ETO16475.1 - 0.0048 16.5 0.1 0.0093 15.6 0.1 1.4 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ETO16475.1 - 0.012 15.5 0.0 0.032 14.1 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family FlaC_arch PF05377.11 ETO16476.1 - 0.031 14.7 0.2 0.031 14.7 0.2 11.5 10 4 3 13 13 13 0 Flagella accessory protein C (FlaC) YmaF PF12788.7 ETO16476.1 - 1.1 9.9 8.0 1.1 9.8 0.2 3.2 3 0 0 3 3 3 0 YmaF family BRI3BP PF14965.6 ETO16476.1 - 8.3 5.9 5.9 43 3.6 0.1 3.6 3 0 0 3 3 3 0 Negative regulator of p53/TP53 DUF3450 PF11932.8 ETO16477.1 - 0.25 10.6 13.5 0.11 11.8 9.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ASD2 PF08687.11 ETO16477.1 - 0.93 9.0 18.5 0.016 14.7 8.9 2.0 1 1 1 2 2 2 0 Apx/Shroom domain ASD2 SAM_PNT PF02198.16 ETO16478.1 - 0.013 15.4 0.4 0.022 14.7 0.4 1.4 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DDE_Tnp_1 PF01609.21 ETO16478.1 - 0.017 14.8 3.3 0.013 15.2 2.0 1.5 1 1 0 1 1 1 0 Transposase DDE domain DUF3153 PF11353.8 ETO16478.1 - 0.022 14.3 0.7 0.028 14.0 0.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3153) Ribosomal_S25 PF03297.15 ETO16478.1 - 0.035 14.3 2.3 0.035 14.3 2.3 3.0 4 0 0 4 4 4 0 S25 ribosomal protein DUF2774 PF11242.8 ETO16479.1 - 0.038 14.2 0.0 0.15 12.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2774) BLOC1_2 PF10046.9 ETO16479.1 - 1.8 8.9 41.6 0.39 11.0 4.6 5.7 4 2 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mod_r PF07200.13 ETO16479.1 - 2 8.5 51.5 6.6 6.8 15.6 4.9 3 2 1 4 4 4 0 Modifier of rudimentary (Mod(r)) protein DUF2316 PF10078.9 ETO16479.1 - 3.6 7.9 8.3 0.47 10.7 0.5 3.2 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2316) LdpA_C PF12617.8 ETO16479.1 - 4.3 6.9 7.1 4.5 6.8 0.3 3.0 3 0 0 3 3 3 0 Iron-Sulfur binding protein C terminal KxDL PF10241.9 ETO16480.1 - 0.013 15.8 5.8 0.013 15.8 5.8 4.3 2 2 2 4 4 4 0 Uncharacterized conserved protein DUF1856 PF08983.10 ETO16480.1 - 0.025 14.8 3.1 0.079 13.2 3.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1856) Sec1 PF00995.23 ETO16481.1 - 3.2e-59 201.7 2.0 9.4e-59 200.1 2.0 1.6 1 1 0 1 1 1 1 Sec1 family UvrD-helicase PF00580.21 ETO16481.1 - 0.071 12.6 0.7 0.099 12.1 0.7 1.2 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain Sec1 PF00995.23 ETO16482.1 - 4.6e-14 52.6 0.1 5.4e-14 52.4 0.1 1.0 1 0 0 1 1 1 1 Sec1 family zf-C3HC4 PF00097.25 ETO16484.1 - 0.00011 22.0 8.4 0.00011 22.0 8.4 5.6 6 1 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) IBR PF01485.21 ETO16484.1 - 0.0022 18.2 3.9 0.0022 18.2 3.9 6.5 3 1 2 5 5 5 1 IBR domain, a half RING-finger domain FYVE PF01363.21 ETO16484.1 - 0.0024 18.0 0.3 0.0024 18.0 0.3 6.2 4 2 1 6 6 6 2 FYVE zinc finger Mucin PF01456.17 ETO16484.1 - 0.2 11.7 30.3 0.66 10.0 30.3 1.9 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 ETO16484.1 - 2 6.4 19.5 3.2 5.8 19.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Borrelia_P83 PF05262.11 ETO16484.1 - 6.6 5.1 30.3 11 4.4 30.3 1.3 1 0 0 1 1 1 0 Borrelia P83/100 protein CENP-B_dimeris PF09026.10 ETO16485.1 - 0.069 13.5 4.8 0.16 12.4 4.8 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain GCIP PF13324.6 ETO16485.1 - 0.84 9.2 7.5 2.1 7.9 7.5 1.7 1 1 0 1 1 1 0 Grap2 and cyclin-D-interacting SAM_1 PF00536.30 ETO16486.1 - 3.2e-15 56.3 2.3 7.3e-08 32.7 0.3 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO16486.1 - 7e-13 48.5 0.6 2.3e-08 34.0 0.2 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Takusan PF04822.13 ETO16486.1 - 0.011 15.6 3.4 0.011 15.6 3.4 2.7 2 1 1 3 3 3 0 Takusan FHIPEP PF00771.20 ETO16486.1 - 0.054 12.0 0.1 0.087 11.3 0.1 1.3 1 0 0 1 1 1 0 FHIPEP family SAM_PNT PF02198.16 ETO16486.1 - 0.12 12.4 0.1 0.12 12.4 0.1 2.5 3 0 0 3 3 3 0 Sterile alpha motif (SAM)/Pointed domain APG6_N PF17675.1 ETO16486.1 - 0.21 12.1 17.2 0.79 10.2 4.6 3.4 3 0 0 3 3 3 0 Apg6 coiled-coil region YabA PF06156.13 ETO16486.1 - 4.2 8.1 16.3 0.25 12.0 0.5 3.1 3 0 0 3 3 3 0 Initiation control protein YabA VirArc_Nuclease PF12187.8 ETO16487.1 - 0.045 13.3 0.1 0.071 12.7 0.1 1.3 1 0 0 1 1 1 0 Viral/Archaeal nuclease Tir_receptor_C PF07489.11 ETO16487.1 - 0.16 11.9 4.4 0.3 11.1 4.4 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus RB_B PF01857.20 ETO16487.1 - 0.28 11.2 3.2 0.72 9.9 3.2 1.8 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain DUF2014 PF09427.10 ETO16488.1 - 0.061 12.7 0.0 0.094 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) zf-UBR PF02207.20 ETO16489.1 - 1.2e-13 51.0 4.7 2.5e-13 50.0 4.7 1.6 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) zf-B_box PF00643.24 ETO16489.1 - 0.06 13.5 4.3 0.23 11.6 4.3 2.1 1 1 0 1 1 1 0 B-box zinc finger Sybindin PF04099.12 ETO16490.1 - 2.9e-35 121.3 0.0 3.4e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 ETO16490.1 - 2.6e-07 30.8 0.0 3.3e-07 30.5 0.0 1.2 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region MMS1_N PF10433.9 ETO16491.1 - 8.9e-58 196.1 5.6 8.9e-58 196.1 5.6 1.7 2 0 0 2 2 2 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ETO16491.1 - 1.2e-30 107.0 0.3 3.2e-30 105.6 0.1 1.8 2 0 0 2 2 2 1 CPSF A subunit region PRF PF06875.11 ETO16491.1 - 0.0035 16.8 0.0 0.0064 15.9 0.0 1.3 1 0 0 1 1 1 1 Plethodontid receptivity factor PRF Exog_C PF18026.1 ETO16491.1 - 0.16 12.1 0.3 0.83 9.8 0.0 2.2 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain WD40 PF00400.32 ETO16492.1 - 3.5e-22 78.3 1.6 1.4e-09 38.4 0.1 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16492.1 - 1.8e-08 34.6 0.2 0.068 13.5 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16492.1 - 7.7e-05 21.5 0.2 0.049 12.3 0.0 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO16492.1 - 0.0082 16.0 0.0 3.4 7.8 0.0 2.9 3 0 0 3 3 3 2 PQQ enzyme repeat Ge1_WD40 PF16529.5 ETO16492.1 - 0.016 14.2 0.1 0.081 11.9 0.0 1.9 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Vhr1 PF04001.13 ETO16493.1 - 0.014 15.7 1.2 0.024 14.9 1.2 1.4 1 0 0 1 1 1 0 Transcription factor Vhr1 EOS1 PF12326.8 ETO16493.1 - 0.32 10.9 2.0 0.44 10.5 2.0 1.2 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 ETO16493.1 - 0.38 10.8 2.5 0.42 10.6 2.5 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CLN3 PF02487.17 ETO16493.1 - 0.88 8.5 2.7 1.1 8.3 2.7 1.1 1 0 0 1 1 1 0 CLN3 protein WD40 PF00400.32 ETO16495.1 - 0.0029 18.4 0.1 0.0058 17.4 0.1 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat TPR_10 PF13374.6 ETO16495.1 - 0.061 13.2 0.0 0.1 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO16495.1 - 0.21 11.9 0.0 0.3 11.4 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat ShK PF01549.24 ETO16496.1 - 5.3e-09 36.5 23.1 1.6e-07 31.8 8.1 2.8 3 0 0 3 3 2 2 ShK domain-like SR-25 PF10500.9 ETO16496.1 - 0.0031 17.2 11.0 0.0039 16.8 11.0 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein DDHD PF02862.17 ETO16496.1 - 0.0082 16.3 0.8 0.0091 16.2 0.8 1.2 1 0 0 1 1 1 1 DDHD domain Tim54 PF11711.8 ETO16496.1 - 0.018 13.8 2.3 0.024 13.5 2.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SpoIIP PF07454.11 ETO16496.1 - 0.029 13.8 2.9 0.037 13.5 2.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Presenilin PF01080.17 ETO16496.1 - 0.041 12.7 2.0 0.047 12.4 2.0 1.2 1 0 0 1 1 1 0 Presenilin DNApol_Exo PF18136.1 ETO16496.1 - 0.051 12.7 2.3 0.067 12.3 2.3 1.2 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF3464 PF11947.8 ETO16496.1 - 0.063 13.0 5.5 0.093 12.5 5.5 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 CPSF100_C PF13299.6 ETO16496.1 - 0.13 12.4 4.7 0.19 11.9 4.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 ETO16496.1 - 0.38 9.7 3.4 0.46 9.4 3.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Coilin_N PF15862.5 ETO16496.1 - 0.44 10.4 14.5 0.66 9.8 14.5 1.3 1 0 0 1 1 1 0 Coilin N-terminus Spt20 PF12090.8 ETO16496.1 - 0.72 9.4 11.0 0.99 9.0 11.0 1.1 1 0 0 1 1 1 0 Spt20 family FdhD-NarQ PF02634.15 ETO16496.1 - 1.2 8.8 6.5 1.7 8.3 6.5 1.2 1 0 0 1 1 1 0 FdhD/NarQ family Peptidase_S49_N PF08496.10 ETO16496.1 - 1.9 8.5 10.6 3.6 7.7 10.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 ETO16496.1 - 2 8.2 10.5 2.8 7.7 10.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Paramyxo_ncap PF00973.19 ETO16496.1 - 2.6 6.8 4.6 3.3 6.5 4.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF4175 PF13779.6 ETO16496.1 - 2.7 5.8 7.3 3.3 5.5 7.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) AIF_C PF14721.6 ETO16496.1 - 5.6 7.3 7.1 9 6.7 7.1 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term TMEMspv1-c74-12 PF11044.8 ETO16497.1 - 0.023 14.7 2.6 0.023 14.7 2.6 2.9 3 1 0 3 3 3 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF2058 PF09831.9 ETO16497.1 - 0.44 10.7 13.2 0.56 10.4 13.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) UPF0542 PF15086.6 ETO16497.1 - 1.5 8.8 8.8 0.16 11.9 3.9 2.1 2 1 1 3 3 3 0 Uncharacterised protein family UPF0542 Connexin PF00029.19 ETO16497.1 - 3.5 7.3 7.5 3.1 7.5 7.1 1.2 1 1 0 1 1 1 0 Connexin PTEN_C2 PF10409.9 ETO16498.1 - 3.3e-12 46.3 0.0 4.7e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein DEP PF00610.21 ETO16498.1 - 1.7e-09 37.6 0.0 3.4e-09 36.6 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) IBR PF01485.21 ETO16499.1 - 0.00011 22.4 13.0 0.00011 22.4 13.0 3.5 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain ubiquitin PF00240.23 ETO16499.1 - 0.00018 21.2 0.1 0.00048 19.8 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin family DUF2407 PF10302.9 ETO16499.1 - 0.00089 19.8 1.1 0.0024 18.4 0.1 2.2 2 0 0 2 2 2 1 DUF2407 ubiquitin-like domain Rad60-SLD PF11976.8 ETO16499.1 - 0.041 13.7 0.1 0.12 12.3 0.1 1.7 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ribosomal_60s PF00428.19 ETO16499.1 - 0.32 11.6 14.7 3.1 8.5 5.7 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein Rhodanese_C PF12368.8 ETO16499.1 - 1.6 9.2 17.0 7.8 7.0 9.3 2.9 2 0 0 2 2 2 0 Rhodanase C-terminal RcsC PF09456.10 ETO16500.1 - 0.12 12.4 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 RcsC Alpha-Beta-Loop (ABL) Pkinase PF00069.25 ETO16501.1 - 0.00018 21.0 0.0 0.00022 20.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Staphostatin_B PF09023.10 ETO16503.1 - 0.073 13.1 0.0 0.18 11.8 0.0 1.6 2 0 0 2 2 2 0 Staphostatin B LRR_6 PF13516.6 ETO16504.1 - 4.9e-10 38.6 11.5 0.0037 17.2 0.3 6.3 6 0 0 6 6 6 3 Leucine Rich repeat Macoilin PF09726.9 ETO16504.1 - 0.0067 15.1 6.7 0.0085 14.7 6.7 1.1 1 0 0 1 1 1 1 Macoilin family LRR_4 PF12799.7 ETO16504.1 - 0.17 12.4 19.4 4.1 8.0 0.3 5.8 5 1 0 5 5 5 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO16504.1 - 0.19 12.4 22.9 18 6.4 0.0 7.2 7 1 0 7 7 7 0 Leucine Rich Repeat LRR_8 PF13855.6 ETO16504.1 - 1.8 8.4 18.9 5.8 6.8 1.1 5.4 5 1 0 5 5 5 0 Leucine rich repeat Ribosomal_S7 PF00177.21 ETO16505.1 - 1.7e-08 34.2 0.0 2.6e-08 33.6 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S7p/S5e AAA PF00004.29 ETO16506.1 - 3.2e-29 102.0 0.0 8.6e-29 100.6 0.0 1.8 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO16506.1 - 1.7e-05 25.2 0.1 0.0013 19.1 0.0 2.6 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETO16506.1 - 7.4e-05 23.0 0.1 0.00044 20.5 0.0 2.3 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO16506.1 - 0.00077 19.5 0.0 0.01 15.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETO16506.1 - 0.0023 18.0 0.0 0.01 16.0 0.0 2.1 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_11 PF13086.6 ETO16506.1 - 0.016 15.0 0.0 0.016 15.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO16506.1 - 0.02 14.6 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO16506.1 - 0.023 14.9 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain Mg_chelatase PF01078.21 ETO16506.1 - 0.024 14.0 0.0 0.057 12.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ETO16506.1 - 0.033 14.1 4.8 2.8 7.8 4.9 3.3 1 1 0 1 1 1 0 NACHT domain AAA_18 PF13238.6 ETO16506.1 - 0.069 13.7 0.9 0.25 11.9 0.0 2.4 2 1 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ETO16506.1 - 0.1 12.5 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_25 PF13481.6 ETO16506.1 - 0.13 11.8 0.1 0.91 9.1 0.0 2.2 2 0 0 2 2 2 0 AAA domain RuvB_N PF05496.12 ETO16506.1 - 0.14 11.9 0.1 0.64 9.8 0.0 2.0 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain TIP49 PF06068.13 ETO16506.1 - 0.17 11.1 0.0 0.34 10.1 0.0 1.5 2 0 0 2 2 2 0 TIP49 P-loop domain Pheromone PF08015.11 ETO16506.1 - 0.23 12.5 5.8 0.75 10.9 5.8 1.8 1 0 0 1 1 1 0 Fungal mating-type pheromone Fringe PF02434.16 ETO16507.1 - 1.2e-06 28.1 0.8 5.7e-06 25.9 0.8 2.1 1 1 0 1 1 1 1 Fringe-like Galactosyl_T PF01762.21 ETO16507.1 - 0.0047 16.8 0.5 0.027 14.3 0.4 2.4 2 1 0 2 2 2 1 Galactosyltransferase V_ATPase_I PF01496.19 ETO16507.1 - 0.016 13.2 0.0 0.021 12.8 0.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF3382 PF11862.8 ETO16508.1 - 0.039 14.2 0.3 0.086 13.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3382) LAB_N PF07578.11 ETO16508.1 - 0.049 13.7 1.4 0.049 13.7 1.4 1.9 1 1 1 2 2 2 0 Lipid A Biosynthesis N-terminal domain EBP50_C PF09007.11 ETO16508.1 - 7.7 7.5 8.0 19 6.2 0.0 3.2 2 2 1 3 3 3 0 EBP50, C-terminal WD40 PF00400.32 ETO16509.1 - 1e-56 187.6 30.1 2.3e-10 40.9 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16509.1 - 6.7e-18 64.8 3.0 0.0048 17.2 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16509.1 - 9.1e-10 38.0 7.9 0.056 12.4 0.0 5.5 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16509.1 - 1.5e-09 38.1 1.0 2.1e-05 24.5 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO16509.1 - 3.6e-08 33.1 1.2 0.00021 20.7 0.2 3.0 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO16509.1 - 1.9e-07 30.2 10.1 0.39 9.3 0.2 6.4 2 1 2 6 6 6 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO16509.1 - 6.4e-06 26.3 5.2 2.3 8.3 0.0 5.6 1 1 5 6 6 6 2 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO16509.1 - 0.016 14.1 0.0 0.041 12.7 0.0 1.7 1 1 1 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO16509.1 - 0.052 13.5 0.1 18 5.4 0.0 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Macoilin PF09726.9 ETO16510.1 - 0.036 12.7 10.5 0.065 11.8 10.5 1.5 1 0 0 1 1 1 0 Macoilin family Raftlin PF15250.6 ETO16510.1 - 0.41 9.4 9.1 0.68 8.6 9.1 1.3 1 0 0 1 1 1 0 Raftlin ALMT PF11744.8 ETO16510.1 - 0.56 9.0 11.2 0.88 8.3 11.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter PNISR PF15996.5 ETO16510.1 - 9.3 6.5 19.7 16 5.7 19.7 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR AMH_N PF04709.12 ETO16511.1 - 0.035 13.0 0.0 0.051 12.5 0.0 1.1 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region TrbC_Ftype PF09673.10 ETO16512.1 - 0.027 14.5 0.2 0.061 13.4 0.1 1.8 1 1 0 1 1 1 0 Type-F conjugative transfer system pilin assembly protein DUF4976 PF16347.5 ETO16513.1 - 0.076 13.3 0.2 0.14 12.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4976) Pkinase PF00069.25 ETO16514.1 - 4.2e-32 111.5 4.1 2.1e-31 109.3 4.1 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16514.1 - 6.5e-07 28.9 3.3 1.8e-05 24.1 3.3 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO16514.1 - 0.00019 20.4 0.0 0.00029 19.7 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase IPK PF03770.16 ETO16514.1 - 0.024 14.5 2.0 0.05 13.5 2.0 1.5 1 1 0 1 1 1 0 Inositol polyphosphate kinase Pox_ser-thr_kin PF05445.11 ETO16514.1 - 0.029 13.3 0.1 0.041 12.8 0.1 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase NT-C2 PF10358.9 ETO16516.1 - 0.00075 19.2 0.8 0.0013 18.4 0.8 1.5 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins FLYWCH_N PF15423.6 ETO16516.1 - 0.012 15.8 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 FLYWCH-type zinc finger-containing protein Hydrolase_3 PF08282.12 ETO16516.1 - 0.14 11.8 0.4 0.18 11.5 0.4 1.3 1 0 0 1 1 1 0 haloacid dehalogenase-like hydrolase SPRY PF00622.28 ETO16517.1 - 0.0038 17.3 0.1 0.014 15.6 0.0 2.0 2 0 0 2 2 2 1 SPRY domain DEAD PF00270.29 ETO16518.1 - 3.6e-05 23.6 0.0 4.9e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 ETO16518.1 - 0.18 11.6 0.0 0.39 10.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Zip PF02535.22 ETO16519.1 - 0.062 12.5 0.1 0.077 12.2 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MAP17 PF15807.5 ETO16519.1 - 0.22 11.8 6.3 0.61 10.3 5.8 2.0 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 EssA PF10661.9 ETO16519.1 - 0.51 10.2 8.9 0.17 11.7 6.2 1.5 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA O-antigen_lig PF13425.6 ETO16519.1 - 2.9 6.6 13.8 0.17 10.6 7.8 1.8 1 1 0 2 2 2 0 O-antigen ligase like membrane protein Ribosomal_S25 PF03297.15 ETO16520.1 - 1.8e-22 79.5 5.3 1.8e-22 79.5 5.3 5.9 2 1 2 4 4 4 2 S25 ribosomal protein HTH_DeoR PF08220.12 ETO16520.1 - 0.13 12.0 0.0 0.24 11.2 0.0 1.3 1 0 0 1 1 1 0 DeoR-like helix-turn-helix domain Menin PF05053.13 ETO16521.1 - 0.0054 15.2 6.7 0.0075 14.7 6.7 1.1 1 0 0 1 1 1 1 Menin Secretin_N_2 PF07655.13 ETO16521.1 - 0.6 10.7 13.0 1.5 9.4 13.0 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain TMF_TATA_bd PF12325.8 ETO16522.1 - 0.00014 22.1 0.7 0.00014 22.1 0.7 2.6 3 0 0 3 3 3 1 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 ETO16522.1 - 0.0021 17.8 3.7 0.0021 17.8 3.7 3.0 3 2 0 3 3 2 1 Septum formation initiator TMF_DNA_bd PF12329.8 ETO16522.1 - 0.0031 17.5 2.6 0.0031 17.5 2.6 2.7 2 0 0 2 2 1 1 TATA element modulatory factor 1 DNA binding DUF3450 PF11932.8 ETO16522.1 - 0.013 14.8 2.0 0.013 14.8 2.0 2.6 2 1 1 3 3 2 0 Protein of unknown function (DUF3450) PGBA_C PF15437.6 ETO16522.1 - 0.032 14.6 15.5 0.092 13.1 15.5 1.7 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA C-terminal BLOC1_2 PF10046.9 ETO16522.1 - 0.038 14.3 3.6 0.038 14.3 3.6 1.9 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ZapB PF06005.12 ETO16522.1 - 0.057 13.9 1.0 0.057 13.9 1.0 3.1 2 1 0 2 2 1 0 Cell division protein ZapB Acylphosphatase PF00708.18 ETO16522.1 - 0.089 13.2 1.6 0.4 11.1 0.3 2.4 2 1 0 2 2 2 0 Acylphosphatase DASH_Dam1 PF08653.10 ETO16522.1 - 0.11 12.4 0.5 5.6 6.8 0.1 2.4 1 1 0 2 2 2 0 DASH complex subunit Dam1 Jnk-SapK_ap_N PF09744.9 ETO16522.1 - 0.12 12.6 0.3 0.12 12.6 0.3 2.4 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Folate_carrier PF01770.18 ETO16522.1 - 0.54 8.9 2.5 0.71 8.5 2.5 1.2 1 0 0 1 1 1 0 Reduced folate carrier Cob_adeno_trans PF01923.18 ETO16522.1 - 2.8 8.1 6.1 6.8 6.8 5.9 1.9 1 1 0 1 1 1 0 Cobalamin adenosyltransferase CCDC106 PF15794.5 ETO16522.1 - 3.2 7.4 22.6 0.033 13.9 12.1 2.1 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 106 SR-25 PF10500.9 ETO16522.1 - 6.6 6.3 26.8 1.2 8.7 22.8 1.7 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dsh_C PF12316.8 ETO16522.1 - 8.6 6.7 16.4 26 5.2 16.4 1.9 1 1 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal WD40 PF00400.32 ETO16523.1 - 2.8e-26 91.2 22.5 1.2e-05 26.0 1.2 5.9 5 2 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO16523.1 - 5.1e-07 28.7 2.7 1.5 7.3 0.0 4.5 3 1 0 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16523.1 - 2.9e-06 27.5 1.2 1.1 9.6 0.0 4.9 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain HARP PF07443.13 ETO16523.1 - 0.091 12.4 0.1 2.8 7.7 0.0 2.6 2 0 0 2 2 2 0 HepA-related protein (HARP) Histone PF00125.24 ETO16526.1 - 9.6e-40 136.0 1.8 9.6e-40 136.0 1.8 2.0 2 0 0 2 2 2 1 Core histone H2A/H2B/H3/H4 PAF PF15715.5 ETO16526.1 - 0.003 18.2 0.5 0.003 18.2 0.5 1.9 2 1 0 2 2 2 1 PCNA-associated factor histone like domain DUF5605 PF18310.1 ETO16528.1 - 0.038 13.9 0.6 0.15 12.0 0.6 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF5605) SPK PF04435.18 ETO16528.1 - 0.45 10.9 5.5 0.27 11.7 0.7 2.8 1 1 1 3 3 3 0 Domain of unknown function (DUF545) TMEM154 PF15102.6 ETO16530.1 - 0.0035 17.3 0.3 0.0037 17.2 0.3 1.0 1 0 0 1 1 1 1 TMEM154 protein family NADH_dehy_S2_C PF06444.11 ETO16530.1 - 0.7 10.5 6.3 1.8 9.1 5.2 2.0 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus PepX_C PF08530.10 ETO16531.1 - 1.2e-25 90.7 0.0 1.3e-25 90.6 0.0 1.0 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Methyltransf_34 PF11312.8 ETO16531.1 - 0.055 12.7 0.1 0.078 12.2 0.1 1.1 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase 7TM-7TMR_HD PF07698.11 ETO16531.1 - 0.21 11.4 2.6 0.33 10.7 2.6 1.3 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase Peptidase_S10 PF00450.22 ETO16533.1 - 6.4e-19 68.7 3.0 2.7e-10 40.3 0.1 2.5 1 1 1 2 2 2 2 Serine carboxypeptidase Peptidase_S10 PF00450.22 ETO16534.1 - 1e-58 199.7 7.0 6.2e-46 157.6 3.4 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase G-alpha PF00503.20 ETO16535.1 - 7.3e-08 32.0 0.8 9.3e-08 31.6 0.8 1.1 1 0 0 1 1 1 1 G-protein alpha subunit PPL5 PF18168.1 ETO16535.1 - 0.59 9.4 6.2 0.78 9.0 6.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Baculo_11_kDa PF06143.11 ETO16536.1 - 0.074 12.6 0.2 0.14 11.7 0.2 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family Ribosomal_L9_C PF03948.14 ETO16537.1 - 0.0035 17.8 0.3 0.0057 17.1 0.3 1.3 1 0 0 1 1 1 1 Ribosomal protein L9, C-terminal domain OEP PF02321.18 ETO16537.1 - 0.12 12.2 3.0 0.076 12.8 1.0 1.7 2 0 0 2 2 2 0 Outer membrane efflux protein MAGUK_N_PEST PF10608.9 ETO16537.1 - 0.52 10.8 6.9 1.7 9.1 6.9 2.1 1 1 0 1 1 1 0 Polyubiquitination (PEST) N-terminal domain of MAGUK SR-25 PF10500.9 ETO16537.1 - 9.8 5.7 18.4 0.19 11.3 8.3 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Mga PF05043.13 ETO16539.1 - 1.3 9.6 8.8 0.74 10.4 4.4 2.9 2 1 1 3 3 3 0 Mga helix-turn-helix domain DUF3298 PF11738.8 ETO16539.1 - 2.3 9.3 5.7 3.5 8.7 0.2 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3298) MA3 PF02847.17 ETO16539.1 - 9.2 6.3 10.1 0.82 9.7 0.7 3.1 2 1 1 3 3 3 0 MA3 domain TPR_12 PF13424.6 ETO16540.1 - 3.5e-65 216.2 12.0 1.5e-14 54.0 0.1 6.2 3 2 2 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO16540.1 - 9.2e-51 168.4 0.0 2e-08 33.8 0.0 9.0 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16540.1 - 8.6e-41 136.1 41.0 1.1e-07 31.3 0.5 8.7 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO16540.1 - 1.2e-38 128.1 42.7 3.9e-06 26.6 0.3 10.1 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO16540.1 - 4.8e-31 104.5 10.6 1.4e-05 24.8 0.1 9.6 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO16540.1 - 7.6e-24 81.9 38.4 0.00041 20.2 1.2 9.8 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO16540.1 - 3.1e-14 53.1 0.3 6.2e-07 29.1 0.1 3.5 2 1 3 5 5 5 3 MalT-like TPR region TPR_14 PF13428.6 ETO16540.1 - 2.2e-11 43.5 1.5 0.73 10.8 0.0 8.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO16540.1 - 3.1e-11 42.8 29.4 0.0087 15.7 0.0 8.7 9 1 1 10 10 10 4 TPR repeat TPR_17 PF13431.6 ETO16540.1 - 2e-08 34.1 10.7 0.015 15.6 0.1 8.3 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO16540.1 - 1.6e-07 31.5 12.2 2.5 8.9 0.0 7.5 8 0 0 8 8 8 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO16540.1 - 6.7e-07 29.4 9.8 0.0013 19.0 0.4 4.8 3 2 2 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO16540.1 - 7e-07 29.8 4.5 1.3 9.7 0.1 6.5 4 2 3 7 7 6 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO16540.1 - 3.1e-06 26.5 5.7 0.024 14.1 0.1 5.4 7 0 0 7 7 7 2 SHNi-TPR DUF5113 PF17140.4 ETO16540.1 - 9.7e-05 22.2 28.0 1.3 8.8 0.1 8.0 6 2 1 8 8 8 4 Domain of unknown function (DUF5113) MIT PF04212.18 ETO16540.1 - 0.0008 19.4 14.0 1.7 8.8 0.1 7.3 7 0 0 7 7 7 1 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO16540.1 - 0.00084 19.8 3.8 0.44 11.1 0.1 4.7 4 1 1 5 5 4 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO16540.1 - 0.11 13.3 15.4 13 6.6 0.1 6.5 7 0 0 7 7 6 0 Sel1 repeat TPR_3 PF07720.12 ETO16540.1 - 0.35 10.9 33.5 0.11 12.5 2.2 6.9 7 0 0 7 7 7 0 Tetratricopeptide repeat DUF892 PF05974.12 ETO16541.1 - 0.04 13.9 0.6 0.04 13.9 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF892) CUE PF02845.16 ETO16541.1 - 0.088 12.5 0.4 0.18 11.6 0.1 1.7 1 1 0 1 1 1 0 CUE domain SPAN-X PF07458.12 ETO16543.1 - 0.0041 17.5 0.9 0.0041 17.5 0.9 2.6 3 1 0 3 3 3 1 Sperm protein associated with nucleus, mapped to X chromosome DUF1178 PF06676.11 ETO16543.1 - 0.39 11.1 6.1 0.059 13.7 1.2 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1178) WD40 PF00400.32 ETO16544.1 - 1.3e-06 29.0 0.3 0.024 15.5 0.0 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat Exo_endo_phos_2 PF14529.6 ETO16545.1 - 0.014 15.3 0.8 0.03 14.2 0.2 1.8 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase SRTM1 PF15872.5 ETO16546.1 - 0.047 13.9 0.0 0.095 12.9 0.0 1.5 1 1 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Kelch_2 PF07646.15 ETO16547.1 - 0.0023 17.8 0.2 0.14 12.2 0.0 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO16547.1 - 0.018 14.6 0.1 0.43 10.2 0.0 2.5 3 0 0 3 3 3 0 Kelch motif LIFR_D2 PF17971.1 ETO16548.1 - 0.032 14.4 1.3 2.6 8.2 0.2 2.6 1 1 1 2 2 2 0 Leukemia inhibitory factor receptor D2 domain DUF916 PF06030.12 ETO16548.1 - 0.036 14.1 1.2 0.036 14.1 1.2 2.2 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF916) CAP_GLY PF01302.25 ETO16549.1 - 4.6e-10 39.4 0.3 8.7e-10 38.5 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain Cnd1 PF12717.7 ETO16549.1 - 0.0002 21.4 1.4 3.7 7.6 0.0 3.4 2 1 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 Peptidase_M24 PF00557.24 ETO16550.1 - 7.9e-40 136.8 0.3 3.8e-22 79.0 0.0 2.1 2 0 0 2 2 2 2 Metallopeptidase family M24 DUF3950 PF13132.6 ETO16551.1 - 0.079 12.7 0.3 3.4 7.5 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3950) tRNA-synt_2b PF00587.25 ETO16553.1 - 2.9e-38 131.6 0.0 5.8e-38 130.6 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ETO16553.1 - 6.3e-22 77.5 0.2 2.6e-21 75.6 0.1 2.0 2 0 0 2 2 2 1 Anticodon binding domain TGS PF02824.21 ETO16553.1 - 5.4e-15 55.2 0.0 1.1e-14 54.2 0.0 1.5 1 0 0 1 1 1 1 TGS domain tRNA_SAD PF07973.14 ETO16553.1 - 2.7e-11 43.4 0.0 6.3e-11 42.2 0.0 1.7 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain FAM76 PF16046.5 ETO16553.1 - 0.025 13.9 4.4 0.052 12.9 4.4 1.4 1 0 0 1 1 1 0 FAM76 protein Pkinase PF00069.25 ETO16555.1 - 1.4e-41 142.6 2.5 1.6e-35 122.8 0.2 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16555.1 - 1.3e-27 96.7 0.3 4.2e-25 88.5 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO16555.1 - 2e-05 24.1 0.0 4.5e-05 22.9 0.0 1.6 1 0 0 1 1 1 1 Kinase-like Goodbye PF17109.5 ETO16555.1 - 1.1 9.7 0.0 1.1 9.7 0.0 2.4 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain PBP_sp32 PF07222.12 ETO16555.1 - 1.8 8.0 11.6 4.5 6.7 11.6 1.7 1 0 0 1 1 1 0 Proacrosin binding protein sp32 WD40 PF00400.32 ETO16556.1 - 5.5e-27 93.5 11.8 5e-07 30.3 0.3 4.9 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16556.1 - 2.4e-10 40.6 0.2 0.013 15.8 0.0 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16556.1 - 5.7e-07 28.6 0.9 0.94 8.0 0.0 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16556.1 - 2.2e-05 23.9 2.1 0.024 14.0 0.2 3.4 2 1 2 4 4 4 3 WD40-like domain Kelch_4 PF13418.6 ETO16557.1 - 1e-06 28.7 0.0 3.6e-05 23.7 0.1 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO16557.1 - 4.9e-05 22.8 1.6 0.00016 21.2 0.7 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO16557.1 - 0.00062 19.6 2.3 0.011 15.7 0.5 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO16557.1 - 0.01 16.1 0.2 0.11 12.8 0.1 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain P-mevalo_kinase PF04275.14 ETO16557.1 - 0.016 15.2 2.5 0.048 13.6 2.5 1.9 1 0 0 1 1 1 0 Phosphomevalonate kinase Kelch_5 PF13854.6 ETO16557.1 - 0.053 13.5 4.2 14 5.8 0.4 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_6 PF13964.6 ETO16557.1 - 0.51 10.7 4.7 53 4.3 0.3 4.3 4 1 1 5 5 5 0 Kelch motif Mannosyl_trans3 PF11051.8 ETO16558.1 - 0.033 13.5 0.5 0.051 12.9 0.5 1.2 1 0 0 1 1 1 0 Mannosyltransferase putative TPR_12 PF13424.6 ETO16559.1 - 5e-39 132.5 7.4 3.5e-19 68.9 1.0 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO16559.1 - 4.5e-18 63.9 13.3 9.6e-08 31.7 1.4 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16559.1 - 6e-18 63.8 14.4 8e-10 38.1 2.3 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO16559.1 - 1.1e-17 63.2 0.1 3.8e-07 29.8 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO16559.1 - 1.4e-17 62.3 13.3 7.3e-06 25.7 1.4 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO16559.1 - 1.6e-17 62.1 3.7 1.3e-05 24.9 0.7 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO16559.1 - 1.3e-07 31.8 5.0 0.00016 22.1 0.7 4.1 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO16559.1 - 1.4e-07 32.0 0.0 0.0089 16.7 0.0 3.3 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO16559.1 - 4e-07 30.3 0.8 0.24 12.3 0.0 4.7 6 0 0 6 6 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO16559.1 - 7.3e-07 28.8 11.3 0.021 14.5 1.7 4.9 3 2 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 ETO16559.1 - 1e-06 28.7 0.8 0.014 15.7 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO16559.1 - 9.9e-06 25.7 0.3 0.0038 17.2 0.1 2.4 1 1 1 2 2 2 1 Caspase domain DUF5113 PF17140.4 ETO16559.1 - 3.3e-05 23.7 1.0 0.41 10.4 0.1 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO16559.1 - 0.00022 21.7 0.8 0.01 16.3 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO16559.1 - 0.00055 19.3 1.0 1.8 8.1 0.0 3.3 3 0 0 3 3 3 2 SHNi-TPR ANAPC3 PF12895.7 ETO16559.1 - 0.0014 18.8 3.8 0.046 13.9 0.6 2.7 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Fis1_TPR_C PF14853.6 ETO16559.1 - 0.0035 17.4 3.8 0.26 11.4 0.3 3.0 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_3 PF07720.12 ETO16559.1 - 0.0042 17.0 5.5 1.6 8.8 0.9 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO16559.1 - 0.0089 16.1 2.5 0.65 10.1 0.5 4.0 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETO16559.1 - 0.013 15.0 3.3 0.13 11.7 2.7 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP ATP-synt_ab_C PF00306.27 ETO16559.1 - 0.054 13.8 1.6 0.16 12.3 1.6 1.8 1 0 0 1 1 1 0 ATP synthase alpha/beta chain, C terminal domain PPR PF01535.20 ETO16559.1 - 0.35 11.2 3.8 26 5.4 0.0 4.1 4 0 0 4 4 3 0 PPR repeat Rap1-DNA-bind PF09197.10 ETO16561.1 - 0.036 14.7 0.3 0.22 12.1 0.3 2.2 2 1 0 2 2 2 0 Rap1, DNA-binding DUF3975 PF13126.6 ETO16561.1 - 0.13 12.7 3.7 0.27 11.7 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3975) PRA1 PF03208.19 ETO16561.1 - 0.63 9.7 13.2 0.5 10.0 5.1 2.4 2 1 0 2 2 2 0 PRA1 family protein PIRT PF15099.6 ETO16561.1 - 1.1 8.8 4.6 2.4 7.7 0.1 2.7 2 1 0 2 2 2 0 Phosphoinositide-interacting protein family MgtE PF01769.16 ETO16561.1 - 3.3 8.1 10.6 8.5 6.8 3.2 2.7 2 1 0 2 2 2 0 Divalent cation transporter DUF3810 PF12725.7 ETO16561.1 - 4 6.7 9.9 1 8.7 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) RRM_1 PF00076.22 ETO16563.1 - 2.7e-15 55.9 0.8 1.7e-13 50.2 0.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 ETO16563.1 - 0.00015 21.6 0.1 0.00023 21.0 0.1 1.2 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Cytochrome_P460 PF16694.5 ETO16563.1 - 0.021 15.1 0.2 0.033 14.5 0.2 1.3 1 0 0 1 1 1 0 Cytochrome P460 ABC_tran PF00005.27 ETO16564.1 - 5.8e-05 23.6 0.1 7e-05 23.4 0.1 1.1 1 0 0 1 1 1 1 ABC transporter AAA_5 PF07728.14 ETO16564.1 - 7.5e-05 22.7 0.0 0.00012 22.0 0.0 1.4 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO16564.1 - 0.00032 20.3 0.0 0.00034 20.2 0.0 1.1 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO16564.1 - 0.00092 19.6 0.2 0.0013 19.1 0.2 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_23 PF13476.6 ETO16564.1 - 0.0013 19.2 0.1 0.0015 19.1 0.1 1.3 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO16564.1 - 0.0015 18.5 0.0 0.0015 18.5 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase ATPase_2 PF01637.18 ETO16564.1 - 0.0024 17.9 0.1 0.0027 17.6 0.1 1.3 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO16564.1 - 0.0026 18.2 0.0 0.0029 18.0 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO16564.1 - 0.0073 16.6 0.1 0.009 16.3 0.1 1.2 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ETO16564.1 - 0.018 14.2 0.0 0.02 14.1 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) TsaE PF02367.17 ETO16564.1 - 0.027 14.5 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ETO16564.1 - 0.04 13.8 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_21 PF13304.6 ETO16564.1 - 0.044 13.6 0.0 0.053 13.3 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_8 PF12780.7 ETO16564.1 - 0.047 13.0 0.1 0.053 12.9 0.1 1.1 1 0 0 1 1 1 0 P-loop containing dynein motor region D4 PduV-EutP PF10662.9 ETO16564.1 - 0.056 13.2 0.6 0.092 12.5 0.4 1.5 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation Sigma54_activat PF00158.26 ETO16564.1 - 0.066 12.9 0.0 0.098 12.4 0.0 1.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_25 PF13481.6 ETO16564.1 - 0.069 12.7 0.0 0.081 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Transp_Tc5_C PF04236.15 ETO16564.1 - 0.073 13.4 0.9 0.18 12.2 0.3 1.9 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain Viral_helicase1 PF01443.18 ETO16564.1 - 0.088 12.5 0.2 0.1 12.4 0.2 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Zeta_toxin PF06414.12 ETO16564.1 - 0.13 11.5 0.0 0.14 11.5 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin DUF5431 PF17496.2 ETO16564.1 - 0.15 12.2 0.1 0.35 11.0 0.0 1.6 1 1 1 2 2 2 0 Family of unknown function (DUF5431) zf-CCCH PF00642.24 ETO16565.1 - 4.8e-09 35.9 1.1 4.8e-09 35.9 1.1 1.9 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO16565.1 - 0.0052 16.8 3.6 0.0052 16.8 3.6 2.0 2 0 0 2 2 2 1 Zinc finger domain PAD_M PF08527.10 ETO16565.1 - 0.0067 16.1 0.5 0.14 11.8 0.1 2.7 2 1 1 3 3 3 1 Protein-arginine deiminase (PAD) middle domain CorA PF01544.18 ETO16565.1 - 0.14 11.4 2.4 0.24 10.7 2.4 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein zf-CCCH_4 PF18044.1 ETO16565.1 - 1.7 8.5 7.0 0.085 12.7 1.3 1.9 2 0 0 2 2 2 0 CCCH-type zinc finger BLM10_mid PF16507.5 ETO16566.1 - 9.8e-16 57.5 4.0 3.9e-11 42.3 0.3 3.9 2 1 0 3 3 3 2 Proteasome-substrate-size regulator, mid region TetR_C_6 PF13977.6 ETO16566.1 - 0.042 14.1 0.0 0.21 11.8 0.0 2.3 2 0 0 2 2 2 0 BetI-type transcriptional repressor, C-terminal Na_trans_assoc PF06512.13 ETO16566.1 - 1.3 9.2 4.6 3.9 7.7 0.3 2.8 3 0 0 3 3 3 0 Sodium ion transport-associated Med14 PF08638.11 ETO16566.1 - 3 7.2 6.0 1.5 8.2 0.3 3.2 3 0 0 3 3 3 0 Mediator complex subunit MED14 Cys_knot PF00007.22 ETO16567.1 - 0.01 16.1 4.9 0.013 15.8 4.9 1.2 1 0 0 1 1 1 0 Cystine-knot domain 14-3-3 PF00244.20 ETO16568.1 - 1.4e-83 279.8 4.2 1.7e-83 279.5 4.2 1.0 1 0 0 1 1 1 1 14-3-3 protein TPR_12 PF13424.6 ETO16568.1 - 4.7e-05 23.6 0.1 0.0001 22.5 0.1 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO16568.1 - 0.0049 17.0 3.0 0.1 12.9 0.4 2.8 2 1 0 2 2 2 1 Tetratricopeptide repeat DUF1987 PF09345.10 ETO16568.1 - 0.013 15.2 0.1 0.036 13.7 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1987) Ta0938 PF11494.8 ETO16568.1 - 0.044 14.1 0.2 0.085 13.1 0.2 1.5 1 0 0 1 1 1 0 Ta0938 CelTOS PF18659.1 ETO16568.1 - 0.1 13.0 0.6 0.22 12.0 0.6 1.6 1 1 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites TPR_10 PF13374.6 ETO16568.1 - 0.12 12.3 0.4 0.58 10.1 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TetR_C_37 PF18665.1 ETO16568.1 - 0.12 13.0 5.6 0.058 14.0 2.8 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_6 PF13174.6 ETO16568.1 - 0.14 12.8 0.6 14 6.6 0.0 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16568.1 - 0.48 10.3 4.4 0.5 10.3 0.7 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO16568.1 - 0.85 9.9 7.9 2.2 8.6 3.2 3.0 2 2 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ETO16570.1 - 2.7e-08 34.3 5.9 0.0029 18.4 0.3 4.1 3 2 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16570.1 - 0.003 17.8 0.2 1.4 9.3 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO16572.1 - 0.023 15.0 1.5 0.12 12.7 0.2 2.8 3 1 1 4 4 4 0 Kelch motif VirK PF06903.12 ETO16572.1 - 0.025 14.7 0.0 0.066 13.3 0.0 1.7 1 1 0 1 1 1 0 VirK protein AP3D1 PF06375.11 ETO16574.1 - 0.1 12.9 5.4 2.3 8.4 0.2 2.1 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Kelch_4 PF13418.6 ETO16575.1 - 4.9e-05 23.2 0.1 0.02 14.9 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO16575.1 - 8e-05 22.1 0.4 0.0005 19.6 0.4 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO16575.1 - 0.0038 17.5 1.3 5.1 7.5 0.0 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO16575.1 - 0.0053 16.7 2.4 4 7.6 1.7 2.8 2 1 0 2 2 2 2 Kelch motif DcpS_C PF11969.8 ETO16575.1 - 0.009 16.5 0.1 0.014 15.8 0.1 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Kelch_5 PF13854.6 ETO16575.1 - 0.22 11.5 1.2 3.5 7.7 1.7 2.2 2 0 0 2 2 2 0 Kelch motif RPEL PF02755.15 ETO16576.1 - 0.002 17.8 7.0 0.0047 16.6 4.1 2.4 2 0 0 2 2 2 1 RPEL repeat CDC45 PF02724.14 ETO16576.1 - 0.57 8.4 8.7 0.63 8.3 8.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO16576.1 - 0.76 8.9 2.2 0.82 8.8 2.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RPEL PF02755.15 ETO16577.1 - 0.00027 20.5 3.9 0.0036 16.9 0.4 2.7 2 0 0 2 2 2 2 RPEL repeat Surfac_D-trimer PF09006.11 ETO16577.1 - 0.13 12.2 0.2 0.25 11.3 0.2 1.5 1 0 0 1 1 1 0 Lung surfactant protein D coiled-coil trimerisation EF-hand_7 PF13499.6 ETO16578.1 - 7.6e-07 29.5 10.8 0.0004 20.8 2.7 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO16578.1 - 8.1e-05 21.9 6.5 0.00039 19.8 1.6 3.6 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 ETO16578.1 - 0.00017 21.3 0.8 0.00017 21.3 0.8 2.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO16578.1 - 0.0005 19.8 7.5 0.0061 16.4 0.5 3.6 5 0 0 5 5 5 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO16578.1 - 0.012 16.0 4.2 0.016 15.5 4.2 1.3 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region WD40 PF00400.32 ETO16579.1 - 4.7e-18 65.2 0.3 1.1e-05 26.1 0.0 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16579.1 - 0.00023 21.4 0.0 5.8 7.3 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO16579.1 - 0.0015 18.5 0.0 0.83 9.5 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO16579.1 - 0.0038 16.2 0.0 0.052 12.5 0.0 2.0 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Spc110_C PF18520.1 ETO16579.1 - 0.064 12.9 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 Spindle pole body component 110 C-terminal domain Nbas_N PF15492.6 ETO16579.1 - 0.065 12.6 0.1 5.2 6.3 0.0 2.5 1 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal zf-TAZ PF02135.16 ETO16579.1 - 0.07 13.6 0.1 0.32 11.5 0.0 1.9 1 1 1 2 2 2 0 TAZ zinc finger PD40 PF07676.12 ETO16579.1 - 0.78 9.8 2.4 1.3 9.0 0.6 2.2 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PIEZO PF15917.5 ETO16580.1 - 0.86 9.0 9.5 1.4 8.3 9.5 1.4 1 0 0 1 1 1 0 Piezo ANAPC_CDC26 PF10471.9 ETO16580.1 - 5.3 7.9 19.4 1 10.2 1.1 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Androgen_recep PF02166.16 ETO16580.1 - 8.5 5.1 9.2 12 4.6 9.2 1.2 1 0 0 1 1 1 0 Androgen receptor DNA_pol3_delta2 PF13177.6 ETO16581.1 - 0.013 15.3 1.4 0.024 14.4 1.4 1.5 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Androgen_recep PF02166.16 ETO16582.1 - 1.3 7.8 15.4 1.8 7.3 15.4 1.2 1 0 0 1 1 1 0 Androgen receptor Trypan_PARP PF05887.11 ETO16582.1 - 1.6 8.7 7.5 2.6 8.0 7.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GREB1 PF15782.5 ETO16583.1 - 0.69 7.0 11.2 0.75 6.8 11.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 ETO16583.1 - 1.3 7.8 10.7 1.4 7.6 10.7 1.1 1 0 0 1 1 1 0 Presenilin Peptidase_S64 PF08192.11 ETO16583.1 - 1.5 7.2 17.9 1.6 7.1 17.9 1.0 1 0 0 1 1 1 0 Peptidase family S64 ALS2CR11 PF15729.5 ETO16583.1 - 2.8 7.0 11.1 3.3 6.7 11.1 1.0 1 0 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 DUF936 PF06075.12 ETO16583.1 - 5.4 5.8 19.1 6.4 5.6 19.1 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Macoilin PF09726.9 ETO16583.1 - 7.1 5.1 22.1 8.9 4.7 22.1 1.0 1 0 0 1 1 1 0 Macoilin family PUB PF09409.10 ETO16584.1 - 0.0048 16.8 0.5 0.026 14.4 0.5 2.4 1 0 0 1 1 1 1 PUB domain CAMSAP_CH PF11971.8 ETO16584.1 - 0.19 11.6 3.1 0.25 11.2 0.6 2.4 2 0 0 2 2 2 0 CAMSAP CH domain NST1 PF13945.6 ETO16585.1 - 8.5 6.4 30.7 1.3 9.1 17.4 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator PAZ PF02170.22 ETO16586.1 - 2.3e-13 50.1 5.0 5.1e-13 49.0 5.0 1.5 1 0 0 1 1 1 1 PAZ domain FliG_C PF01706.16 ETO16586.1 - 0.02 15.1 2.4 9.9 6.4 0.1 3.4 3 0 0 3 3 3 0 FliG C-terminal domain Pentapeptide PF00805.22 ETO16587.1 - 2.8e-09 36.4 0.1 3.7e-07 29.7 0.1 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) WD40 PF00400.32 ETO16587.1 - 1.3e-08 35.3 1.1 0.014 16.2 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat Pentapeptide_4 PF13599.6 ETO16587.1 - 1.1e-05 25.6 0.0 2.7e-05 24.2 0.0 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO16587.1 - 9.5e-05 22.5 0.1 0.00052 20.1 0.1 2.0 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO16587.1 - 0.084 12.8 2.3 8.7 6.4 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat VIR_N PF15912.5 ETO16587.1 - 5.9 6.4 8.3 0.093 12.3 0.2 2.1 3 0 0 3 3 3 0 Virilizer, N-terminal Fe_hyd_lg_C PF02906.14 ETO16588.1 - 0.021 14.5 0.0 0.028 14.1 0.0 1.2 1 0 0 1 1 1 0 Iron only hydrogenase large subunit, C-terminal domain 2TM PF13239.6 ETO16588.1 - 3.4 8.0 12.5 2.9 8.3 7.0 2.6 2 0 0 2 2 2 0 2TM domain U-box PF04564.15 ETO16589.1 - 2.3e-19 69.3 0.1 2.3e-19 69.3 0.1 1.9 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 ETO16589.1 - 1.8e-05 24.4 0.0 4.1e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-NOSIP PF15906.5 ETO16589.1 - 0.00046 20.3 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-C3HC4_2 PF13923.6 ETO16589.1 - 0.07 13.0 0.0 0.21 11.4 0.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) POX PF07526.11 ETO16589.1 - 0.15 12.7 5.7 11 6.6 4.2 2.3 2 0 0 2 2 2 0 Associated with HOX RP-C_C PF11800.8 ETO16589.1 - 2.1 8.4 10.9 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 Replication protein C C-terminal region PMC2NT PF08066.12 ETO16590.1 - 0.65 10.7 3.5 0.69 10.6 0.1 2.8 3 0 0 3 3 3 0 PMC2NT (NUC016) domain Kelch_4 PF13418.6 ETO16592.1 - 0.012 15.6 0.1 0.21 11.6 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO16592.1 - 0.09 13.1 0.8 30 5.1 0.1 3.4 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO16593.1 - 2.1e-35 120.1 21.2 3.8e-08 33.8 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16593.1 - 1e-11 44.9 0.2 0.0025 18.1 0.0 5.2 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16593.1 - 0.00042 19.4 0.6 0.36 9.8 0.1 3.5 2 2 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ_3 PF13570.6 ETO16593.1 - 0.013 16.0 1.3 13 6.5 0.4 4.2 3 2 1 4 4 4 0 PQQ-like domain Frtz PF11768.8 ETO16593.1 - 0.12 10.7 0.0 0.61 8.3 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PAN_3 PF08277.12 ETO16593.1 - 0.14 12.0 0.1 5.1 7.0 0.0 2.4 2 0 0 2 2 2 0 PAN-like domain FA_desaturase PF00487.24 ETO16594.1 - 1.3e-22 80.9 18.4 3.3e-22 79.5 18.4 1.5 1 1 0 1 1 1 1 Fatty acid desaturase WD40 PF00400.32 ETO16595.1 - 0.0039 18.0 6.4 0.012 16.5 0.7 3.1 3 2 0 3 3 3 2 WD domain, G-beta repeat Sulf_transp PF04143.14 ETO16596.1 - 2.4e-33 116.0 29.4 8.2e-19 68.3 7.9 2.1 1 1 1 2 2 2 2 Sulphur transport DsbD_2 PF13386.6 ETO16597.1 - 5.6e-06 26.4 2.5 5.6e-06 26.4 2.5 1.6 2 0 0 2 2 2 1 Cytochrome C biogenesis protein transmembrane region Srg PF02118.21 ETO16597.1 - 0.042 13.5 3.4 0.16 11.6 1.2 2.1 2 0 0 2 2 2 0 Srg family chemoreceptor EcsB PF05975.12 ETO16597.1 - 0.085 11.7 2.3 0.21 10.4 0.0 2.1 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB BRO1 PF03097.18 ETO16598.1 - 2.8e-16 59.3 4.0 6.1e-16 58.2 4.0 1.4 1 1 0 1 1 1 1 BRO1-like domain DUF5397 PF17375.2 ETO16600.1 - 0.065 13.0 0.0 0.17 11.6 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5397) COG5 PF10392.9 ETO16601.1 - 0.0024 18.1 5.4 0.0028 17.8 5.0 1.4 1 1 0 1 1 1 1 Golgi transport complex subunit 5 DUF1192 PF06698.11 ETO16601.1 - 0.018 15.1 1.4 0.018 15.1 1.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PH PF00169.29 ETO16602.1 - 9.5e-15 55.0 2.1 2.8e-14 53.5 2.1 1.9 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO16602.1 - 5.3e-08 33.2 1.6 5.3e-08 33.2 1.6 3.0 3 1 0 3 3 3 1 Pleckstrin homology domain PH_6 PF15406.6 ETO16602.1 - 0.00033 20.9 1.6 0.00064 20.0 0.0 2.3 2 0 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO16602.1 - 0.00052 20.1 1.3 0.0012 19.0 1.0 1.8 1 1 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 ETO16602.1 - 0.00085 19.2 0.7 0.0022 17.8 0.7 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ETO16602.1 - 0.002 18.3 1.7 0.03 14.6 1.6 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PMAIP1 PF15150.6 ETO16602.1 - 0.058 13.3 0.5 0.13 12.2 0.5 1.6 1 0 0 1 1 1 0 Phorbol-12-myristate-13-acetate-induced PH_3 PF14593.6 ETO16602.1 - 0.082 13.0 1.7 0.72 10.0 0.0 2.7 3 0 0 3 3 3 0 PH domain Med13_C PF06333.12 ETO16602.1 - 1.1 8.5 11.7 0.098 11.9 6.5 1.6 1 1 1 2 2 2 0 Mediator complex subunit 13 C-terminal domain Aha1_N PF09229.11 ETO16603.1 - 1.8e-15 57.4 1.6 1.8e-15 57.4 1.6 2.5 2 1 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal RGS-like PF09128.11 ETO16603.1 - 3.6 7.3 8.8 0.82 9.4 1.2 2.3 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain LmjF365940-deam PF14421.6 ETO16604.1 - 4.8e-47 160.1 0.0 1e-46 159.0 0.0 1.5 1 0 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.23 ETO16604.1 - 0.076 12.9 0.0 0.63 10.0 0.0 2.2 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region NST1 PF13945.6 ETO16604.1 - 4.3 7.4 10.3 12 6.0 5.7 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator TMEM154 PF15102.6 ETO16605.1 - 0.0073 16.2 2.9 0.0088 16.0 2.9 1.2 1 0 0 1 1 1 1 TMEM154 protein family HPHLAWLY PF14925.6 ETO16605.1 - 0.0076 15.0 5.8 0.009 14.7 5.8 1.0 1 0 0 1 1 1 1 Domain of unknown function zf-RanBP PF00641.18 ETO16606.1 - 3e-08 32.8 2.9 6.5e-08 31.8 2.9 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Protocadherin PF08374.11 ETO16606.1 - 0.0087 16.1 10.6 0.0087 16.1 10.6 2.4 2 1 0 2 2 2 1 Protocadherin Secretin_N_2 PF07655.13 ETO16606.1 - 0.022 15.3 11.4 0.022 15.3 11.4 5.7 5 1 1 6 6 6 0 Secretin N-terminal domain ParD_antitoxin PF03693.14 ETO16606.1 - 0.097 13.1 1.8 1.4 9.3 0.0 3.0 3 0 0 3 3 3 0 Bacterial antitoxin of ParD toxin-antitoxin type II system and RHH WD40 PF00400.32 ETO16607.1 - 3.4e-06 27.7 2.3 3.7e-05 24.4 1.1 2.7 2 2 0 2 2 2 1 WD domain, G-beta repeat Ig_6 PF18452.1 ETO16607.1 - 0.017 14.7 0.1 0.03 13.9 0.1 1.3 1 0 0 1 1 1 0 Immunoglobulin domain DUF1299 PF06975.11 ETO16607.1 - 0.039 14.0 0.0 0.074 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1299) DUF658 PF04936.12 ETO16607.1 - 0.089 12.5 0.4 0.11 12.2 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF658) Sulfotransfer_1 PF00685.27 ETO16608.1 - 8.3e-08 32.0 0.0 1.1e-07 31.7 0.0 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO16608.1 - 0.002 18.6 0.0 0.0027 18.1 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase family Sulfotransfer_4 PF17784.1 ETO16608.1 - 0.097 12.5 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 Sulfotransferase domain Pkinase PF00069.25 ETO16610.1 - 0.0038 16.6 2.0 0.0062 15.9 2.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO16611.1 - 4.1e-52 177.2 0.0 5.3e-52 176.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16611.1 - 4.5e-26 91.7 0.0 6e-26 91.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ETO16611.1 - 1e-05 26.1 0.9 1.9e-05 25.3 0.9 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ETO16611.1 - 0.00085 18.7 0.0 0.00098 18.5 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO16611.1 - 0.03 13.1 0.0 0.043 12.6 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 ETO16611.1 - 0.047 13.0 0.0 0.08 12.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO16611.1 - 0.064 13.2 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO16611.1 - 0.12 11.3 0.0 0.17 10.8 0.0 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Inhibitor_Mig-6 PF11555.8 ETO16611.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 EGFR receptor inhibitor Mig-6 Pkinase PF00069.25 ETO16612.1 - 9.3e-25 87.5 0.3 5.4e-18 65.3 0.3 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_fungal PF17667.1 ETO16612.1 - 0.00068 18.5 0.0 0.00092 18.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ETO16612.1 - 0.0089 15.7 0.3 0.02 14.5 0.2 1.6 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Pkinase_Tyr PF07714.17 ETO16612.1 - 0.02 14.2 0.0 0.03 13.6 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase Kdo PF06293.14 ETO16612.1 - 0.11 11.9 0.1 0.18 11.1 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase PF00069.25 ETO16613.1 - 0.073 12.4 0.1 0.31 10.4 0.0 1.9 2 0 0 2 2 2 0 Protein kinase domain Mucin-like PF16058.5 ETO16613.1 - 0.3 11.2 3.3 0.57 10.3 2.9 1.5 1 1 0 1 1 1 0 Mucin-like TPR_12 PF13424.6 ETO16614.1 - 3.7e-06 27.1 0.8 7.9e-06 26.1 0.8 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO16614.1 - 0.0012 18.8 5.8 0.0015 18.5 0.2 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO16614.1 - 0.0031 18.0 0.6 0.031 14.9 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO16614.1 - 0.009 15.8 3.1 0.0097 15.7 0.1 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO16614.1 - 0.011 15.7 1.5 0.02 14.9 0.1 2.2 3 0 0 3 3 3 0 Tetratricopeptide repeat PTS_IIA PF02255.16 ETO16614.1 - 0.039 14.0 1.0 0.068 13.2 1.0 1.4 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Med29 PF11568.8 ETO16614.1 - 0.047 13.9 1.9 0.91 9.7 0.1 2.8 1 1 1 3 3 3 0 Mediator complex subunit 29 TPR_8 PF13181.6 ETO16614.1 - 0.12 12.7 5.3 0.44 10.9 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1394 PF07159.12 ETO16615.1 - 6.4e-40 137.3 9.4 2.1e-31 109.3 5.2 3.0 2 1 0 2 2 2 2 Protein of unknown function (DUF1394) Thiolase_C PF02803.18 ETO16615.1 - 0.022 14.4 0.4 0.061 13.0 0.0 1.9 2 0 0 2 2 2 0 Thiolase, C-terminal domain Frag1 PF10277.9 ETO16615.1 - 0.052 13.1 4.5 0.091 12.3 4.5 1.4 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family TRAM_LAG1_CLN8 PF03798.16 ETO16615.1 - 0.053 13.3 3.7 0.088 12.5 3.7 1.3 1 0 0 1 1 1 0 TLC domain Cbl_N PF02262.16 ETO16615.1 - 0.86 9.6 4.2 0.83 9.7 0.1 2.8 2 1 1 3 3 3 0 CBL proto-oncogene N-terminal domain 1 TPR_8 PF13181.6 ETO16616.1 - 0.13 12.5 0.1 0.3 11.4 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DAO PF01266.24 ETO16617.1 - 4.2e-13 49.6 0.0 3.2e-09 36.8 0.4 2.7 2 1 0 2 2 2 2 FAD dependent oxidoreductase GIDA PF01134.22 ETO16617.1 - 2.6e-08 33.4 0.1 0.0047 16.1 0.0 2.1 2 0 0 2 2 2 2 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ETO16617.1 - 1.2e-07 31.3 0.0 2e-05 24.0 0.0 2.8 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO16617.1 - 2.2e-07 31.0 1.0 2.2e-06 27.8 0.2 2.6 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ETO16617.1 - 6.2e-07 29.9 0.7 0.00071 20.1 0.3 2.4 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETO16617.1 - 0.00014 21.1 0.1 0.00041 19.6 0.1 1.7 2 0 0 2 2 2 1 FAD binding domain 3HCDH_N PF02737.18 ETO16617.1 - 0.00017 21.6 0.0 0.00025 21.0 0.0 1.2 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 ETO16617.1 - 0.00022 20.1 0.2 0.0034 16.1 0.1 2.4 3 0 0 3 3 3 1 HI0933-like protein NAD_binding_7 PF13241.6 ETO16617.1 - 0.00037 20.9 0.0 0.00072 20.0 0.0 1.4 1 0 0 1 1 1 1 Putative NAD(P)-binding FAD_binding_3 PF01494.19 ETO16617.1 - 0.00078 18.8 0.1 0.0016 17.8 0.1 1.5 2 0 0 2 2 2 1 FAD binding domain ApbA PF02558.16 ETO16617.1 - 0.0011 18.6 0.0 0.0024 17.6 0.0 1.6 2 0 0 2 2 1 1 Ketopantoate reductase PanE/ApbA Thi4 PF01946.17 ETO16617.1 - 0.0014 18.0 0.1 0.0043 16.3 0.1 1.8 2 0 0 2 2 2 1 Thi4 family UDPG_MGDP_dh_N PF03721.14 ETO16617.1 - 0.0036 16.9 0.4 0.0061 16.1 0.4 1.3 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain Pyr_redox_3 PF13738.6 ETO16617.1 - 0.007 15.7 0.1 0.036 13.3 0.0 1.9 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DUF1188 PF06690.11 ETO16617.1 - 0.007 15.9 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1188) TrkA_N PF02254.18 ETO16617.1 - 0.0082 16.4 0.0 0.015 15.6 0.0 1.4 1 0 0 1 1 1 1 TrkA-N domain AlaDh_PNT_C PF01262.21 ETO16617.1 - 0.0083 15.4 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain Sacchrp_dh_NADP PF03435.18 ETO16617.1 - 0.014 15.6 0.1 0.041 14.2 0.0 1.8 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ETO16617.1 - 0.032 14.3 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase FAD_oxidored PF12831.7 ETO16617.1 - 0.034 13.5 0.8 0.056 12.8 0.8 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GMC_oxred_N PF00732.19 ETO16617.1 - 0.069 12.5 0.0 4.3 6.6 0.0 2.2 2 0 0 2 2 2 0 GMC oxidoreductase Rossmann-like PF10727.9 ETO16617.1 - 0.073 12.9 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Rossmann-like domain NAD_binding_2 PF03446.15 ETO16617.1 - 0.22 11.7 0.0 0.4 10.8 0.0 1.4 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase Trp_halogenase PF04820.14 ETO16617.1 - 0.4 9.5 1.9 0.41 9.5 0.5 1.7 2 0 0 2 2 2 0 Tryptophan halogenase ATR13 PF16829.5 ETO16619.1 - 0.029 14.7 0.1 0.05 13.9 0.1 1.4 1 0 0 1 1 1 0 Avirulence protein ATR13, RxLR effector C9orf72-like PF15019.6 ETO16619.1 - 0.04 13.5 1.6 0.47 10.0 0.2 2.0 2 0 0 2 2 2 0 C9orf72-like protein family Phage_Gp23 PF10669.9 ETO16619.1 - 0.14 12.5 0.8 0.19 12.1 0.8 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) PAH PF02671.21 ETO16620.1 - 1e-08 35.2 1.3 1e-08 35.2 1.3 1.9 2 0 0 2 2 2 1 Paired amphipathic helix repeat Atg14 PF10186.9 ETO16621.1 - 0.21 10.6 6.7 0.19 10.8 6.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 ETO16621.1 - 0.26 11.1 9.6 0.27 11.1 9.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF724) WD40 PF00400.32 ETO16623.1 - 4e-08 33.8 8.3 0.00019 22.1 3.0 3.5 2 2 0 2 2 2 2 WD domain, G-beta repeat DUF4958 PF16319.5 ETO16623.1 - 0.028 12.4 0.1 0.028 12.4 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4958) RPEL PF02755.15 ETO16624.1 - 1.5e-08 34.1 3.7 0.028 14.1 1.4 4.3 3 0 0 3 3 3 3 RPEL repeat KxDL PF10241.9 ETO16624.1 - 1.8 8.9 25.7 6.7 7.1 2.8 4.8 4 0 0 4 4 4 0 Uncharacterized conserved protein RdRP PF05183.12 ETO16625.1 - 5.9e-37 127.6 0.0 2e-36 125.8 0.0 1.9 1 1 0 1 1 1 1 RNA dependent RNA polymerase Cys_rich_KTR PF14205.6 ETO16625.1 - 0.19 11.5 1.4 0.75 9.6 0.4 2.5 2 0 0 2 2 2 0 Cysteine-rich KTR SR-25 PF10500.9 ETO16628.1 - 2 7.9 29.6 3.9 7.0 18.0 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein TCP PF03634.13 ETO16628.1 - 8.7 6.9 25.7 0.93 10.0 18.6 2.1 2 0 0 2 2 2 0 TCP family transcription factor Ras PF00071.22 ETO16629.1 - 5.3e-37 126.9 0.0 9.5e-34 116.3 0.0 2.6 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO16629.1 - 7.8e-27 93.9 0.0 2.3e-26 92.4 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO16629.1 - 1.3e-09 37.8 0.0 2.4e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO16629.1 - 1.4e-07 31.6 0.0 3.3e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO16629.1 - 3.5e-06 26.6 1.4 6.1e-06 25.8 0.0 2.1 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO16629.1 - 4.6e-05 23.0 0.2 0.00014 21.4 0.0 1.9 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO16629.1 - 0.00039 20.4 0.1 0.023 14.6 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 ETO16629.1 - 0.0031 17.2 0.5 2.2 8.0 0.0 2.4 2 0 0 2 2 2 2 AAA domain AAA_22 PF13401.6 ETO16629.1 - 0.069 13.4 0.0 0.71 10.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ETO16629.1 - 0.093 12.5 0.0 0.19 11.5 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_16 PF13191.6 ETO16629.1 - 0.19 12.1 0.0 0.41 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain BUD22 PF09073.10 ETO16629.1 - 2.8 7.2 25.7 4.6 6.5 18.0 2.0 2 0 0 2 2 2 0 BUD22 AAA_18 PF13238.6 ETO16629.1 - 6.2 7.4 10.0 36 4.9 0.0 3.8 3 1 0 3 3 3 0 AAA domain SKA1 PF07160.12 ETO16630.1 - 0.01 15.7 0.9 0.01 15.7 0.9 1.9 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 ddrB-ParB PF18763.1 ETO16630.1 - 0.021 14.9 0.1 0.059 13.5 0.0 1.8 2 0 0 2 2 2 0 ddrB-like ParB superfamily domain DUF1043 PF06295.12 ETO16630.1 - 2.6 8.1 10.8 2.3 8.2 6.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) MID_MedPIWI PF18296.1 ETO16630.1 - 8.7 6.1 9.1 24 4.6 9.1 1.8 1 1 0 1 1 1 0 MID domain of medPIWI Pkinase PF00069.25 ETO16631.1 - 4.3e-54 183.6 0.1 5.1e-54 183.4 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16631.1 - 1.5e-29 103.0 0.0 1.9e-29 102.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO16631.1 - 1.5e-05 24.0 0.1 4.1e-05 22.5 0.0 1.6 1 1 1 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO16631.1 - 0.0003 20.2 0.2 0.00052 19.4 0.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family NPR3 PF03666.13 ETO16632.1 - 0.047 12.5 12.2 0.056 12.2 12.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Raftlin PF15250.6 ETO16632.1 - 0.79 8.4 8.1 0.89 8.2 8.1 1.0 1 0 0 1 1 1 0 Raftlin Pox_Ag35 PF03286.14 ETO16632.1 - 0.93 9.2 16.0 1.4 8.6 16.0 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF5614 PF18474.1 ETO16632.1 - 0.94 8.7 10.6 6.1 6.1 10.6 2.2 1 1 0 1 1 1 0 Family of unknown function (DUF5614) Ctf8 PF09696.10 ETO16632.1 - 1.4 9.2 6.2 13 6.1 6.0 2.2 1 1 0 1 1 1 0 Ctf8 CDC45 PF02724.14 ETO16632.1 - 1.4 7.1 15.1 1.5 7.0 15.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO16632.1 - 2.1 6.6 12.5 2.3 6.5 12.5 1.1 1 0 0 1 1 1 0 Menin Tim54 PF11711.8 ETO16632.1 - 2.2 7.0 8.2 2.6 6.8 8.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2457 PF10446.9 ETO16632.1 - 2.3 7.3 24.7 2.6 7.1 24.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) V_ATPase_I PF01496.19 ETO16632.1 - 2.4 6.0 10.3 2.9 5.7 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Zip PF02535.22 ETO16632.1 - 2.7 7.1 8.5 2.8 7.1 8.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CPSF100_C PF13299.6 ETO16632.1 - 2.9 8.0 11.4 5.2 7.2 11.4 1.5 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 ETO16632.1 - 3.3 6.5 6.4 3.5 6.3 6.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Nop14 PF04147.12 ETO16632.1 - 5.2 5.1 23.4 6 4.9 23.4 1.0 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO16632.1 - 6.7 5.4 11.9 7.8 5.1 11.9 1.2 1 0 0 1 1 1 0 Presenilin Ureide_permease PF07168.11 ETO16632.1 - 8.5 5.0 5.9 10 4.7 5.9 1.1 1 0 0 1 1 1 0 Ureide permease adh_short PF00106.25 ETO16634.1 - 2.6e-19 69.5 0.0 2.8e-19 69.4 0.0 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO16634.1 - 3.8e-16 59.4 0.0 4.1e-16 59.3 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO16634.1 - 5.7e-05 23.1 0.0 5.9e-05 23.1 0.0 1.0 1 0 0 1 1 1 1 KR domain Glyco_tran_WecB PF03808.13 ETO16634.1 - 0.014 15.4 0.0 0.014 15.3 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family Sacchrp_dh_NADP PF03435.18 ETO16634.1 - 0.032 14.5 0.0 0.035 14.4 0.0 1.1 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SLATT_6 PF18169.1 ETO16634.1 - 0.057 13.0 0.1 0.074 12.7 0.1 1.1 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 6 Methyltransf_12 PF08242.12 ETO16636.1 - 4.5e-08 33.7 0.1 4.6e-07 30.5 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO16636.1 - 1e-07 32.6 0.0 0.0039 17.8 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_31 PF13847.6 ETO16636.1 - 1.4e-06 28.2 0.1 0.002 18.0 0.0 2.2 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_11 PF08241.12 ETO16636.1 - 1.9e-06 28.4 0.0 0.0042 17.7 0.0 2.4 2 0 0 2 2 2 2 Methyltransferase domain CheR PF01739.18 ETO16636.1 - 2.8e-05 23.7 0.0 0.00011 21.7 0.0 1.8 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain Pox_MCEL PF03291.16 ETO16636.1 - 3.4e-05 23.1 0.3 0.0054 15.9 0.3 2.7 2 1 0 2 2 2 1 mRNA capping enzyme Methyltransf_23 PF13489.6 ETO16636.1 - 0.00024 21.0 0.0 0.00042 20.2 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain NodS PF05401.11 ETO16636.1 - 0.013 15.2 0.0 0.029 14.0 0.0 1.6 2 0 0 2 2 2 0 Nodulation protein S (NodS) Secretin_N_2 PF07655.13 ETO16637.1 - 1.7 9.2 11.1 4.3 8.0 11.1 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain SPATA1_C PF15743.5 ETO16637.1 - 5.8 7.0 9.8 4 7.5 4.9 2.5 1 1 1 2 2 2 0 Spermatogenesis-associated C-terminus WD40 PF00400.32 ETO16639.1 - 3.8e-38 128.8 27.0 7.6e-07 29.7 0.5 7.4 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16639.1 - 2.2e-13 50.3 2.8 0.024 14.9 0.1 5.5 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16639.1 - 5.9e-08 31.8 5.9 0.67 8.5 0.0 5.2 2 2 2 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16639.1 - 0.00029 20.3 11.5 0.0064 15.9 1.9 4.0 2 2 2 4 4 4 2 WD40-like domain DUF4221 PF13970.6 ETO16639.1 - 0.66 9.5 8.1 0.33 10.5 4.6 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4221) DUF4217 PF13959.6 ETO16641.1 - 0.00043 20.5 0.0 0.001 19.2 0.0 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Pec_lyase_N PF04431.13 ETO16641.1 - 0.0043 17.3 0.3 0.26 11.5 0.0 2.5 2 0 0 2 2 2 2 Pectate lyase, N terminus DEAD PF00270.29 ETO16642.1 - 2.1e-41 141.6 0.0 3.5e-41 140.9 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO16642.1 - 7.3e-14 52.0 0.0 4e-12 46.5 0.0 3.0 3 0 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO16642.1 - 1.7e-07 31.4 1.9 5.1e-07 29.8 0.0 2.2 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit PI3K_1B_p101 PF10486.9 ETO16642.1 - 1.1 7.0 6.7 1.4 6.6 6.7 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit WD40 PF00400.32 ETO16644.1 - 1.8e-28 98.2 11.9 2.4e-06 28.1 0.1 6.4 6 2 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO16644.1 - 1.3e-07 30.6 2.1 0.1 11.2 0.0 3.9 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16644.1 - 2.1e-06 27.9 0.4 0.63 10.4 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF851 PF05867.11 ETO16644.1 - 0.056 12.9 0.0 2.3 7.6 0.0 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF851) DUF3959 PF13105.6 ETO16645.1 - 0.13 11.7 9.5 0.24 10.8 9.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) FAM60A PF15396.6 ETO16645.1 - 0.94 9.4 10.7 1.5 8.8 10.7 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Neur_chan_memb PF02932.16 ETO16645.1 - 1.2 9.1 5.0 1.3 9.0 5.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 ETO16645.1 - 1.6 7.5 8.4 1.5 7.6 8.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM70 PF14967.6 ETO16645.1 - 1.6 8.1 6.0 0.45 9.9 2.6 1.8 2 0 0 2 2 2 0 FAM70 protein DUF4834 PF16118.5 ETO16645.1 - 3.5 8.6 10.3 0.81 10.7 6.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SGS PF05002.15 ETO16646.1 - 0.031 14.4 1.6 0.091 12.9 1.6 1.8 1 0 0 1 1 1 0 SGS domain PPR_2 PF13041.6 ETO16648.1 - 8.9e-10 38.6 3.8 4.2e-08 33.3 0.5 3.0 2 1 1 3 3 3 2 PPR repeat family PPR_3 PF13812.6 ETO16648.1 - 9.4e-09 35.2 1.0 9.8e-06 25.6 0.2 3.2 2 1 1 3 3 3 2 Pentatricopeptide repeat domain PPR PF01535.20 ETO16648.1 - 2e-07 30.8 0.2 0.0058 16.8 0.0 2.7 2 0 0 2 2 2 2 PPR repeat PPR_1 PF12854.7 ETO16648.1 - 3.6e-07 29.8 0.4 0.00033 20.3 0.0 2.7 2 0 0 2 2 2 2 PPR repeat PPR_long PF17177.4 ETO16648.1 - 0.014 14.8 0.7 0.038 13.3 0.1 1.9 2 1 0 2 2 2 0 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO16648.1 - 0.061 13.2 2.1 0.13 12.1 0.2 2.4 1 1 1 2 2 2 0 Mitochondrial ATPase expression EF1G PF00647.19 ETO16648.1 - 0.07 13.2 0.1 0.17 12.0 0.1 1.7 1 0 0 1 1 1 0 Elongation factor 1 gamma, conserved domain Adeno_52K PF03052.15 ETO16648.1 - 0.12 11.8 0.0 0.26 10.7 0.0 1.5 1 0 0 1 1 1 0 Adenoviral protein L1 52/55-kDa Trypan_PARP PF05887.11 ETO16650.1 - 3e-06 27.2 13.1 5.8e-06 26.3 13.1 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) NESP55 PF06390.12 ETO16650.1 - 0.00076 19.2 14.7 0.0014 18.3 14.7 1.4 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) SPESP1 PF15754.5 ETO16650.1 - 0.0026 17.0 7.1 0.0039 16.4 7.1 1.3 1 0 0 1 1 1 1 Sperm equatorial segment protein 1 TonB_N PF16031.5 ETO16650.1 - 0.012 16.2 14.6 0.021 15.3 14.6 1.5 1 0 0 1 1 1 0 TonB polyproline region Neisseria_TspB PF05616.13 ETO16650.1 - 0.26 9.7 3.4 0.31 9.5 3.4 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PBP_N PF17093.5 ETO16650.1 - 2.9 8.2 10.4 1.6 9.0 8.1 1.7 1 1 1 2 2 2 0 Penicillin-binding protein N-terminus WD40 PF00400.32 ETO16651.1 - 4e-61 201.5 18.1 9e-11 42.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16651.1 - 8.5e-23 80.5 1.6 1.2e-06 28.7 0.0 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16651.1 - 4.7e-10 38.9 0.7 0.078 11.9 0.1 5.3 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO16651.1 - 1.2e-09 38.0 1.2 3.7e-05 23.2 0.1 3.3 1 1 2 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO16651.1 - 3.5e-09 36.8 0.2 2.6e-06 27.4 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO16651.1 - 2.1e-06 26.7 6.9 0.17 10.5 0.1 5.5 1 1 4 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO16651.1 - 1.4e-05 23.8 4.9 0.099 11.2 0.1 3.1 2 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO16651.1 - 0.00047 20.0 2.2 2.9 7.9 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 ETO16651.1 - 0.0012 18.4 0.0 0.027 13.9 0.0 2.8 1 1 2 3 3 3 1 Domain of unknown function (DUF5046) Resistin PF06954.11 ETO16651.1 - 0.0099 16.4 0.3 8.6 7.0 0.0 4.1 5 0 0 5 5 5 1 Resistin PALB2_WD40 PF16756.5 ETO16651.1 - 0.033 13.1 0.1 18 4.1 0.0 3.7 2 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain SBD PF17882.1 ETO16651.1 - 0.04 13.7 0.0 13 5.6 0.0 3.0 2 2 1 3 3 3 0 OAA-family lectin sugar binding domain DUF5570 PF17731.1 ETO16651.1 - 0.047 13.8 0.1 13 5.9 0.0 4.0 4 1 2 6 6 6 0 Family of unknown function (DUF5570) Hep_core_N PF08290.11 ETO16651.1 - 2.6 8.1 7.7 18 5.5 1.9 3.2 3 0 0 3 3 3 0 Hepatitis core protein, putative zinc finger zf-TRAF PF02176.18 ETO16652.1 - 1.9e-05 25.3 0.6 1.9e-05 25.3 0.6 2.7 3 1 0 3 3 3 1 TRAF-type zinc finger TEX19 PF15553.6 ETO16652.1 - 0.011 15.7 0.1 0.019 15.0 0.1 1.4 1 0 0 1 1 1 0 Testis-expressed protein 19 betaPIX_CC PF16523.5 ETO16652.1 - 0.013 15.3 2.3 0.031 14.1 2.3 1.6 1 0 0 1 1 1 0 betaPIX coiled coil SOGA PF11365.8 ETO16652.1 - 0.016 16.3 4.7 0.058 14.5 4.7 1.9 1 0 0 1 1 1 0 Protein SOGA WD40 PF00400.32 ETO16653.1 - 1.3e-38 130.3 29.7 3.4e-07 30.8 0.2 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16653.1 - 7.8e-14 51.8 1.2 0.033 14.5 0.0 5.4 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16653.1 - 1.8e-08 34.1 6.5 0.00083 18.8 1.6 4.4 2 2 3 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO16653.1 - 5e-07 28.7 5.6 0.015 13.9 0.5 4.5 2 2 2 4 4 4 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO16654.1 - 3.1e-05 24.6 4.5 0.00082 20.1 1.2 2.9 2 2 0 2 2 2 2 WD domain, G-beta repeat Ubiquitin_3 PF14836.6 ETO16655.1 - 0.14 12.2 1.6 15 5.6 0.1 2.8 2 0 0 2 2 2 0 Ubiquitin-like domain DASH_Dam1 PF08653.10 ETO16655.1 - 0.28 11.0 12.4 5.7 6.8 0.1 5.5 6 1 0 6 6 6 0 DASH complex subunit Dam1 DDE_Tnp_IS240 PF13610.6 ETO16655.1 - 0.47 10.7 6.0 3.3 7.9 0.4 2.9 2 2 0 2 2 2 0 DDE domain DUF1216 PF06746.11 ETO16655.1 - 0.65 10.0 17.6 0.55 10.2 2.5 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1216) Bcr-Abl_Oligo PF09036.10 ETO16655.1 - 0.65 10.0 8.9 0.38 10.8 1.0 3.6 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain BLOC1_2 PF10046.9 ETO16655.1 - 4.1 7.8 22.0 0.074 13.4 1.3 4.5 5 1 0 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MPS2 PF17060.5 ETO16656.1 - 0.042 13.1 19.3 0.049 12.9 18.4 1.5 1 1 0 1 1 1 0 Monopolar spindle protein 2 PilJ PF13675.6 ETO16656.1 - 0.12 12.4 1.4 0.24 11.4 0.1 1.8 1 1 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term G-gamma PF00631.22 ETO16656.1 - 0.5 10.4 3.8 0.28 11.2 0.3 2.2 2 0 0 2 2 2 0 GGL domain EF1_GNE PF00736.19 ETO16656.1 - 0.72 10.1 9.3 0.12 12.5 4.5 2.1 2 1 1 3 3 3 0 EF-1 guanine nucleotide exchange domain Exonuc_VII_L PF02601.15 ETO16656.1 - 1.1 8.8 14.3 1.4 8.4 14.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 ETO16656.1 - 2.6 8.1 34.1 5.7 7.0 30.8 2.5 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FAM76 PF16046.5 ETO16656.1 - 3.9 6.8 25.1 1.1 8.6 9.9 2.2 1 1 1 2 2 2 0 FAM76 protein CAP_GLY PF01302.25 ETO16657.1 - 2e-11 43.7 0.2 3.6e-11 42.9 0.2 1.4 1 0 0 1 1 1 1 CAP-Gly domain SAM_1 PF00536.30 ETO16657.1 - 2.4e-10 40.7 0.0 4.9e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO16657.1 - 1.2e-05 25.3 0.0 2.9e-05 24.1 0.0 1.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO16657.1 - 0.16 11.9 0.0 0.52 10.3 0.0 1.8 1 1 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain WD40 PF00400.32 ETO16658.1 - 2.8e-09 37.4 1.8 5.4e-05 23.9 0.1 3.4 2 1 1 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16658.1 - 0.00069 19.9 0.0 0.06 13.6 0.0 2.6 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Cwf_Cwc_15 PF04889.12 ETO16658.1 - 0.013 15.2 6.5 0.016 14.9 6.5 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RRN3 PF05327.11 ETO16658.1 - 0.2 10.1 2.4 0.26 9.8 2.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RXT2_N PF08595.11 ETO16658.1 - 0.34 10.9 8.8 7.3 6.6 8.3 2.2 2 0 0 2 2 2 0 RXT2-like, N-terminal DUF4598 PF15370.6 ETO16658.1 - 0.66 10.5 6.1 1.1 9.7 6.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) DUF3245 PF11595.8 ETO16658.1 - 0.73 10.3 8.4 1.1 9.7 8.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) CDC45 PF02724.14 ETO16658.1 - 0.75 8.0 7.7 0.88 7.8 7.7 1.1 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETO16658.1 - 2.1 8.0 6.8 3.4 7.3 6.8 1.3 1 0 0 1 1 1 0 FAM176 family HORMA PF02301.18 ETO16659.1 - 3.1e-14 53.1 0.0 4.9e-14 52.4 0.0 1.3 1 0 0 1 1 1 1 HORMA domain DUF3377 PF11857.8 ETO16659.1 - 0.11 12.5 0.1 0.28 11.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) TFIIA PF03153.13 ETO16660.1 - 0.023 14.7 21.6 0.026 14.5 21.6 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PAT1 PF09770.9 ETO16660.1 - 0.059 11.6 11.9 0.064 11.5 11.9 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 CUE PF02845.16 ETO16660.1 - 0.31 10.8 0.0 0.31 10.8 0.0 3.0 3 1 0 3 3 3 0 CUE domain LD_cluster2 PF18163.1 ETO16660.1 - 1.5 8.2 5.4 2.2 7.7 0.1 2.0 1 1 1 2 2 2 0 SLOG cluster2 Activator_LAG-3 PF11498.8 ETO16660.1 - 4.4 6.2 31.1 6.1 5.7 31.1 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Kelch_2 PF07646.15 ETO16661.1 - 0.0004 20.2 0.4 0.055 13.5 0.3 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO16661.1 - 0.0023 18.1 1.3 2.3 8.6 0.0 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO16661.1 - 0.0024 17.4 0.4 0.041 13.5 0.6 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO16661.1 - 0.09 12.8 1.1 0.53 10.3 0.5 2.5 2 1 0 2 2 2 0 Galactose oxidase, central domain LD_cluster2 PF18163.1 ETO16661.1 - 0.1 12.1 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 SLOG cluster2 ATP-grasp_6 PF18419.1 ETO16662.1 - 0.11 12.1 0.0 1.4 8.6 0.0 2.3 2 0 0 2 2 2 0 ATP-grasp-like domain TraP PF07296.11 ETO16662.1 - 0.22 10.7 0.7 5.9 6.0 0.1 2.4 1 1 1 2 2 2 0 TraP protein Menin PF05053.13 ETO16664.1 - 5.5 5.2 10.9 6.9 4.9 10.9 1.2 1 0 0 1 1 1 0 Menin WD40 PF00400.32 ETO16665.1 - 1.6e-08 35.0 5.6 9.7e-08 32.6 1.4 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO16665.1 - 0.00052 18.8 0.1 0.00075 18.3 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16665.1 - 0.00072 19.8 0.0 0.0011 19.2 0.0 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Asp PF00026.23 ETO16666.1 - 1.8e-09 37.4 0.1 3.9e-08 33.1 0.1 2.5 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO16666.1 - 1.3e-08 35.2 0.8 1.3e-08 35.2 0.8 2.3 3 0 0 3 3 3 1 Xylanase inhibitor N-terminal Methyltransf_12 PF08242.12 ETO16666.1 - 0.012 16.3 5.5 0.87 10.4 0.3 2.9 3 0 0 3 3 3 0 Methyltransferase domain TAXi_C PF14541.6 ETO16666.1 - 0.044 13.6 0.0 0.17 11.6 0.0 2.0 1 1 0 1 1 1 0 Xylanase inhibitor C-terminal gag-asp_proteas PF13975.6 ETO16666.1 - 0.14 12.7 0.0 0.38 11.3 0.0 1.7 1 0 0 1 1 1 0 gag-polyprotein putative aspartyl protease Orf78 PF06024.12 ETO16666.1 - 0.17 12.2 9.1 0.21 11.9 0.6 2.4 2 0 0 2 2 2 0 Orf78 (ac78) TAXi_N PF14543.6 ETO16667.1 - 5.8e-14 52.7 4.2 8.8e-14 52.1 4.2 1.3 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal Asp PF00026.23 ETO16667.1 - 1.8e-05 24.3 0.0 2.5e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Orf78 PF06024.12 ETO16667.1 - 1.5 9.1 8.2 4.9 7.5 7.6 2.0 2 0 0 2 2 2 0 Orf78 (ac78) zf-FCS PF06467.14 ETO16667.1 - 2.3 8.2 10.0 4.6 7.3 10.0 1.5 1 1 0 1 1 1 0 MYM-type Zinc finger with FCS sequence motif TLP-20 PF06088.11 ETO16668.1 - 0.018 14.9 2.0 0.018 14.9 2.0 1.3 1 1 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF4304 PF14137.6 ETO16668.1 - 0.95 9.6 6.9 1.6 8.9 6.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4304) EzrA PF06160.12 ETO16669.1 - 0.0015 16.8 11.1 0.0018 16.5 11.1 1.1 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA FapA PF03961.13 ETO16669.1 - 0.068 11.8 7.8 0.078 11.6 7.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF2560 PF10834.8 ETO16669.1 - 0.14 12.4 1.6 0.17 12.1 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2560) DUF2098 PF09871.9 ETO16669.1 - 0.85 10.0 8.1 0.42 11.0 5.9 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) DivIC PF04977.15 ETO16669.1 - 1.9 8.3 6.9 0.98 9.2 1.5 2.5 1 1 2 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 ETO16669.1 - 2.2 7.6 4.5 2.6 7.3 4.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) N-glycanase_N PF09112.10 ETO16670.1 - 0.0093 15.8 0.8 0.017 14.9 0.8 1.4 1 0 0 1 1 1 1 Peptide-N-glycosidase F, N terminal Phage_lysis PF03245.13 ETO16670.1 - 0.016 15.3 0.3 0.016 15.3 0.3 2.4 2 1 1 3 3 3 0 Bacteriophage Rz lysis protein TGT_C2 PF14810.6 ETO16670.1 - 0.067 13.3 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Patch-forming domain C2 of tRNA-guanine transglycosylase Jnk-SapK_ap_N PF09744.9 ETO16670.1 - 0.08 13.2 18.9 0.024 14.9 11.3 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 PRKG1_interact PF15898.5 ETO16670.1 - 0.081 13.8 10.6 1.2 10.1 6.2 2.4 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF2353 PF09789.9 ETO16670.1 - 0.081 12.3 16.3 6.7 6.0 16.3 2.0 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) HEPN_Toprim_N PF18871.1 ETO16670.1 - 0.095 12.6 2.1 0.17 11.8 1.5 1.4 1 1 0 1 1 1 0 HEPN/Toprim N-terminal domain 1 MIS13 PF08202.11 ETO16670.1 - 0.15 11.3 13.2 0.18 11.1 13.2 1.2 1 0 0 1 1 1 0 Mis12-Mtw1 protein family FUSC PF04632.12 ETO16670.1 - 0.23 10.0 2.0 0.26 9.8 2.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family V_ATPase_I PF01496.19 ETO16670.1 - 0.28 9.1 8.4 0.33 8.8 8.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HMMR_N PF15905.5 ETO16670.1 - 0.3 10.5 16.3 0.47 9.9 16.3 1.3 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF3452 PF11934.8 ETO16670.1 - 0.39 10.3 4.8 0.7 9.5 4.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) Fez1 PF06818.15 ETO16670.1 - 0.55 10.7 14.7 1.4 9.3 14.7 1.7 1 1 0 1 1 1 0 Fez1 DHR10 PF18595.1 ETO16670.1 - 0.79 9.8 18.5 0.25 11.4 4.9 3.0 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain SpecificRecomb PF10136.9 ETO16670.1 - 0.9 7.8 3.8 1.1 7.4 3.8 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF3450 PF11932.8 ETO16670.1 - 1.2 8.4 14.2 0.079 12.3 7.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Tropomyosin_1 PF12718.7 ETO16670.1 - 1.2 9.3 16.6 0.53 10.4 9.9 2.7 1 1 1 2 2 2 0 Tropomyosin like APG6_N PF17675.1 ETO16670.1 - 1.5 9.3 17.1 1.1 9.8 14.1 2.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Glutaredoxin2_C PF04399.13 ETO16670.1 - 1.6 8.6 6.9 3.1 7.7 2.4 2.7 2 1 1 3 3 3 0 Glutaredoxin 2, C terminal domain FapA PF03961.13 ETO16670.1 - 1.9 7.0 7.5 3.1 6.3 7.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A AKNA PF12443.8 ETO16670.1 - 2 9.1 10.7 3.5 8.3 3.1 2.6 1 1 2 3 3 3 0 AT-hook-containing transcription factor DUF4201 PF13870.6 ETO16670.1 - 3 7.6 18.2 1.3 8.8 11.7 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Med9 PF07544.13 ETO16670.1 - 3.7 7.7 11.0 6.2 7.0 3.6 2.7 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Laminin_II PF06009.12 ETO16670.1 - 5.7 7.0 11.4 1.7 8.7 5.2 2.1 2 0 0 2 2 2 0 Laminin Domain II UPF0242 PF06785.11 ETO16670.1 - 6.8 6.7 17.6 1.8 8.6 10.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Allexi_40kDa PF05549.11 ETO16670.1 - 7.2 6.0 9.8 3.4 7.1 3.1 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein Spc24 PF08286.11 ETO16670.1 - 8.3 6.7 16.7 46 4.3 6.0 3.0 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Serinc PF03348.15 ETO16673.1 - 4.9e-06 25.7 0.2 6e-06 25.5 0.2 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) CENP-B_dimeris PF09026.10 ETO16673.1 - 0.00056 20.3 0.7 0.0011 19.3 0.7 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DUF2681 PF10883.8 ETO16673.1 - 0.00068 20.0 6.3 0.00068 20.0 6.3 1.9 3 0 0 3 3 1 1 Protein of unknown function (DUF2681) FGF-BP1 PF06473.12 ETO16673.1 - 0.0012 18.7 1.9 0.0016 18.3 1.9 1.1 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) DUF4446 PF14584.6 ETO16673.1 - 0.0073 16.3 1.4 0.0073 16.3 1.4 1.5 2 0 0 2 2 1 1 Protein of unknown function (DUF4446) MscS_TM PF12794.7 ETO16673.1 - 0.0085 15.0 2.0 0.014 14.2 2.0 1.3 1 1 0 1 1 1 1 Mechanosensitive ion channel inner membrane domain 1 DUF2254 PF10011.9 ETO16673.1 - 0.0093 14.8 0.3 0.0093 14.8 0.3 1.5 1 1 0 1 1 1 1 Predicted membrane protein (DUF2254) Connexin PF00029.19 ETO16673.1 - 0.012 15.4 0.4 0.017 14.9 0.4 1.3 1 0 0 1 1 1 0 Connexin Folate_carrier PF01770.18 ETO16673.1 - 0.016 14.0 1.0 0.021 13.6 1.0 1.1 1 0 0 1 1 1 0 Reduced folate carrier 7tm_1 PF00001.21 ETO16673.1 - 0.016 14.5 0.0 0.022 14.1 0.0 1.2 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Scs3p PF10261.9 ETO16673.1 - 0.017 14.6 0.5 0.025 14.1 0.5 1.2 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM DUF913 PF06025.12 ETO16673.1 - 0.022 13.7 0.1 0.025 13.6 0.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4746 PF15928.5 ETO16673.1 - 0.023 14.1 4.7 0.031 13.7 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_3_Rpc31 PF11705.8 ETO16673.1 - 0.036 14.3 12.8 0.049 13.9 12.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Orf78 PF06024.12 ETO16673.1 - 0.04 14.2 0.9 0.43 10.9 0.0 2.4 1 1 1 2 2 2 0 Orf78 (ac78) PdaC PF13739.6 ETO16673.1 - 0.056 14.4 3.4 0.11 13.5 3.4 1.6 1 0 0 1 1 1 0 Deacetylase PdaC RPN2_C PF18004.1 ETO16673.1 - 0.067 13.1 10.6 0.11 12.5 10.6 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain AAA_11 PF13086.6 ETO16673.1 - 0.096 12.5 2.8 0.12 12.2 2.8 1.1 1 0 0 1 1 1 0 AAA domain TRAP_alpha PF03896.16 ETO16673.1 - 0.11 11.6 4.4 0.16 11.1 4.4 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CLN3 PF02487.17 ETO16673.1 - 0.17 10.9 3.0 0.22 10.6 3.0 1.2 1 1 0 1 1 1 0 CLN3 protein MAP17 PF15807.5 ETO16673.1 - 0.79 10.0 6.1 1.5 9.0 6.1 1.4 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Astro_capsid_p PF12226.8 ETO16673.1 - 1.1 8.3 6.6 1.7 7.7 6.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Vfa1 PF08432.10 ETO16673.1 - 5.2 7.4 13.6 8.2 6.7 13.6 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FAM176 PF14851.6 ETO16673.1 - 6.4 6.4 13.3 1.8 8.2 9.7 1.9 2 1 0 2 2 2 0 FAM176 family Mannosyl_trans2 PF04188.13 ETO16675.1 - 3.2e-18 66.3 36.1 2.4e-17 63.4 36.1 1.9 1 1 0 1 1 1 1 Mannosyltransferase (PIG-V) TRIQK PF15168.6 ETO16675.1 - 0.77 9.7 0.0 0.77 9.7 0.0 3.0 3 0 0 3 3 3 0 Triple QxxK/R motif-containing protein family MinE PF03776.14 ETO16677.1 - 0.15 12.1 0.6 1.1 9.4 0.0 2.1 2 0 0 2 2 2 0 Septum formation topological specificity factor MinE FliP PF00813.20 ETO16678.1 - 4.9 7.0 9.3 9.9 6.0 9.3 1.5 1 0 0 1 1 1 0 FliP family Annexin PF00191.20 ETO16679.1 - 1.1e-36 124.7 0.1 2e-10 40.6 0.0 4.4 4 0 0 4 4 4 4 Annexin DUF5101 PF17031.5 ETO16679.1 - 0.017 15.2 0.3 0.044 13.9 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) GATase PF00117.28 ETO16680.1 - 1.4e-10 41.2 0.1 3.7e-10 39.9 0.1 1.6 1 1 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO16680.1 - 5.4e-05 23.1 0.1 0.00018 21.4 0.0 2.0 3 0 0 3 3 3 1 Peptidase C26 DJ-1_PfpI PF01965.24 ETO16680.1 - 0.0025 17.6 0.0 0.0044 16.8 0.0 1.3 1 0 0 1 1 1 1 DJ-1/PfpI family MCPsignal PF00015.21 ETO16680.1 - 0.022 14.6 0.3 0.056 13.3 0.3 1.6 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain MscS_TM PF12794.7 ETO16682.1 - 0.45 9.3 4.4 0.61 8.9 4.4 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 GYF PF02213.16 ETO16683.1 - 2.1e-13 49.7 3.1 2.3e-13 49.5 1.7 1.9 1 1 0 1 1 1 1 GYF domain Comm PF15957.5 ETO16683.1 - 0.07 13.5 0.4 0.07 13.5 0.4 3.0 4 0 0 4 4 4 0 Commissureless Bap31 PF05529.12 ETO16683.1 - 0.21 11.4 1.0 0.6 10.0 0.2 2.2 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region TLD PF07534.16 ETO16684.1 - 1.3e-15 57.8 0.7 1.3e-15 57.8 0.7 2.3 2 0 0 2 2 2 1 TLD fn3 PF00041.21 ETO16684.1 - 0.001 19.4 0.7 0.0032 17.8 0.7 2.0 1 0 0 1 1 1 1 Fibronectin type III domain Fer4_13 PF13370.6 ETO16684.1 - 0.11 13.0 0.0 0.36 11.4 0.0 1.8 1 0 0 1 1 1 0 4Fe-4S single cluster domain of Ferredoxin I DUF4834 PF16118.5 ETO16684.1 - 4.2 8.4 11.1 0.055 14.4 1.2 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) ETRAMP PF09716.10 ETO16684.1 - 7 6.8 9.9 0.18 11.8 2.5 2.2 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Pox_Ag35 PF03286.14 ETO16685.1 - 0.13 12.0 5.9 0.19 11.5 5.9 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RFXA_RFXANK_bdg PF15289.6 ETO16685.1 - 0.18 12.1 3.3 0.28 11.5 3.3 1.2 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain Ras PF00071.22 ETO16686.1 - 2.7e-15 56.4 4.7 3.7e-08 33.1 1.0 3.1 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ETO16686.1 - 1.4e-10 41.4 0.1 0.00049 20.3 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase DUF2721 PF11026.8 ETO16686.1 - 0.04 13.8 0.0 0.11 12.4 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Dynamin_N PF00350.23 ETO16686.1 - 0.23 11.5 1.3 0.8 9.7 0.0 2.3 2 0 0 2 2 2 0 Dynamin family Y_phosphatase3 PF13350.6 ETO16687.1 - 7.4e-05 22.8 4.5 0.00071 19.6 0.0 3.2 3 0 0 3 3 3 1 Tyrosine phosphatase family DSPc PF00782.20 ETO16687.1 - 0.0006 19.6 0.1 0.0006 19.6 0.1 4.9 5 1 1 6 6 6 1 Dual specificity phosphatase, catalytic domain McyA_C PF12593.8 ETO16687.1 - 0.012 15.4 0.0 0.035 13.9 0.0 1.7 1 0 0 1 1 1 0 Microcystin synthetase C terminal MCM_OB PF17207.3 ETO16687.1 - 0.062 13.1 2.2 0.23 11.3 2.2 2.0 1 0 0 1 1 1 0 MCM OB domain Cys_rich_VLP PF14194.6 ETO16688.1 - 0.012 15.8 0.1 0.019 15.1 0.1 1.3 1 0 0 1 1 1 0 Cysteine-rich VLP DUF2458 PF10454.9 ETO16689.1 - 0.0029 17.3 2.9 0.0033 17.1 2.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2458) SPX PF03105.19 ETO16689.1 - 0.1 12.5 1.1 0.13 12.1 1.1 1.1 1 0 0 1 1 1 0 SPX domain DUF2165 PF09933.9 ETO16689.1 - 0.2 11.7 0.1 0.28 11.2 0.1 1.2 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) SLX9 PF15341.6 ETO16690.1 - 3.6 8.0 10.2 21 5.5 0.1 2.5 2 1 0 2 2 2 0 Ribosome biogenesis protein SLX9 DUF3837 PF12939.7 ETO16691.1 - 0.014 15.7 0.0 0.025 15.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3837) DUF3734 PF12536.8 ETO16691.1 - 0.087 13.2 1.2 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Patatin phospholipase Spt20 PF12090.8 ETO16691.1 - 0.37 10.4 7.5 0.51 9.9 7.5 1.2 1 0 0 1 1 1 0 Spt20 family M_domain PF12938.7 ETO16691.1 - 5.8 6.6 11.5 2.7 7.7 8.9 1.7 2 0 0 2 2 2 0 M domain of GW182 DUF1295 PF06966.12 ETO16692.1 - 7.7e-42 143.4 0.1 8.5e-42 143.3 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 ETO16692.1 - 9.9e-07 28.8 0.3 3.1e-06 27.2 0.3 1.7 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 ETO16692.1 - 0.0033 17.8 0.8 0.0054 17.1 0.0 1.8 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO16692.1 - 0.032 14.6 0.1 0.052 13.9 0.1 1.4 1 0 0 1 1 1 0 Phospholipid methyltransferase CAP_GLY PF01302.25 ETO16694.1 - 4.3e-09 36.3 0.6 9.9e-09 35.1 0.6 1.6 1 0 0 1 1 1 1 CAP-Gly domain MLD PF11647.8 ETO16694.1 - 0.097 13.0 0.1 2.5 8.4 0.0 2.3 2 0 0 2 2 2 0 Membrane Localization Domain WD40 PF00400.32 ETO16695.1 - 2.9e-31 107.0 16.9 3.8e-06 27.5 0.5 7.0 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16695.1 - 1e-10 41.8 0.7 0.0057 16.9 0.0 4.6 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16695.1 - 2e-06 26.8 4.4 0.064 11.9 0.1 4.5 1 1 2 4 4 4 3 Nucleoporin Nup120/160 UPF0556 PF10572.9 ETO16695.1 - 0.016 14.7 0.5 0.073 12.6 0.2 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0556 WD40 PF00400.32 ETO16696.1 - 1.5e-55 183.9 14.6 1.9e-09 38.0 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16696.1 - 1e-18 67.4 3.1 0.00026 21.2 0.1 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16696.1 - 3.6e-15 55.8 2.8 0.0012 17.9 0.0 5.8 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16696.1 - 1.3e-12 48.0 0.7 7.6e-05 22.7 0.0 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO16696.1 - 1.8e-10 39.9 1.7 0.0017 17.0 0.1 3.7 2 1 1 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO16696.1 - 1.2e-08 34.1 14.7 0.097 11.3 0.1 5.7 1 1 5 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO16696.1 - 3.2e-08 33.3 2.1 0.88 9.6 0.0 5.8 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO16696.1 - 8.3e-06 24.8 4.4 0.036 12.8 0.2 3.0 1 1 2 3 3 3 2 Nup133 N terminal like WD40_like PF17005.5 ETO16696.1 - 3.7e-05 23.2 0.3 0.035 13.4 0.0 3.2 1 1 1 3 3 3 1 WD40-like domain DUF5570 PF17731.1 ETO16696.1 - 0.00064 19.8 5.4 0.72 10.0 0.1 4.1 1 1 2 4 4 4 1 Family of unknown function (DUF5570) PALB2_WD40 PF16756.5 ETO16696.1 - 0.011 14.6 3.3 0.29 10.0 0.1 3.4 1 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF4988 PF16378.5 ETO16696.1 - 0.013 15.1 0.4 0.2 11.3 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function Resistin PF06954.11 ETO16696.1 - 0.015 15.8 0.3 9.5 6.9 0.0 3.3 2 1 1 3 3 3 0 Resistin SBD PF17882.1 ETO16696.1 - 0.022 14.6 0.4 3 7.7 0.1 3.0 1 1 2 3 3 3 0 OAA-family lectin sugar binding domain Ricin_B_lectin PF00652.22 ETO16696.1 - 0.051 13.8 3.9 1.2 9.3 0.3 2.8 2 1 0 3 3 2 0 Ricin-type beta-trefoil lectin domain Big_3_5 PF16640.5 ETO16696.1 - 0.075 13.2 3.8 48 4.2 0.0 4.1 4 1 0 4 4 4 0 Bacterial Ig-like domain (group 3) Glyco_hydro_30C PF17189.4 ETO16696.1 - 0.24 11.7 4.1 16 5.8 0.0 4.1 1 1 2 3 3 3 0 Glycosyl hydrolase family 30 beta sandwich domain Kelch_4 PF13418.6 ETO16697.1 - 5.4e-07 29.5 0.1 0.0003 20.7 0.0 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO16697.1 - 1.1e-05 25.2 0.1 11 6.1 0.0 4.9 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO16697.1 - 3.7e-05 23.9 1.9 0.24 11.7 0.1 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO16697.1 - 0.00017 21.5 2.9 0.042 13.8 0.1 3.8 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO16697.1 - 0.0012 18.4 0.2 0.56 9.8 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Lipl32 PF12103.8 ETO16697.1 - 0.03 14.0 1.0 2.9 7.5 0.0 2.3 2 0 0 2 2 2 0 Surface lipoprotein of Spirochaetales order WD40 PF00400.32 ETO16698.1 - 1.9e-30 104.4 34.4 7.1e-05 23.5 2.1 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 ETO16698.1 - 2e-10 40.0 5.3 1.9e-05 23.5 0.6 3.9 3 1 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16698.1 - 4.9e-08 33.2 2.2 0.061 13.6 0.1 5.2 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16698.1 - 2.1e-06 27.3 12.5 0.0074 15.6 0.6 5.6 1 1 5 6 6 6 3 WD40-like domain SH3_13 PF18335.1 ETO16698.1 - 1 9.3 3.9 5.9 6.8 0.1 3.6 4 0 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain WD40 PF00400.32 ETO16699.1 - 1.5e-51 171.2 22.5 9.3e-10 39.0 0.3 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16699.1 - 4e-17 62.3 5.2 0.00026 21.2 0.1 5.2 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO16699.1 - 6.8e-12 45.7 1.7 3.1e-08 33.7 0.3 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO16699.1 - 1e-08 34.9 6.9 0.00011 21.7 0.2 3.0 2 1 0 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO16699.1 - 2.1e-08 33.5 1.3 0.14 11.1 0.0 5.5 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO16699.1 - 1.8e-06 26.9 3.3 0.41 9.2 0.0 4.5 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO16699.1 - 4.2e-06 25.5 0.2 0.053 12.1 0.0 2.4 1 1 2 3 3 3 3 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO16699.1 - 0.0026 16.7 6.9 0.75 8.7 2.3 4.0 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DPPIV_N PF00930.21 ETO16699.1 - 0.0036 16.1 0.0 1.3 7.7 0.1 3.4 1 1 2 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO16699.1 - 0.0099 15.8 8.8 8.2 6.5 0.2 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat MIase PF02426.16 ETO16699.1 - 0.021 15.0 0.1 58 3.9 0.0 4.1 4 1 1 5 5 5 0 Muconolactone delta-isomerase PQQ PF01011.21 ETO16699.1 - 0.026 14.5 0.5 2.5 8.2 0.0 3.6 4 0 0 4 4 4 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO16699.1 - 0.035 12.9 3.7 0.67 8.6 0.4 3.4 1 1 1 2 2 2 0 Nup133 N terminal like VWA PF00092.28 ETO16700.1 - 0.011 16.0 0.1 0.022 15.0 0.1 1.6 1 1 0 1 1 1 0 von Willebrand factor type A domain Isochorismatase PF00857.20 ETO16700.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.6 2 0 0 2 2 2 0 Isochorismatase family FMN_red PF03358.15 ETO16700.1 - 0.2 11.4 0.0 0.4 10.4 0.0 1.4 1 0 0 1 1 1 0 NADPH-dependent FMN reductase PT PF04886.12 ETO16700.1 - 1.5 8.5 6.5 3.7 7.2 6.5 1.6 1 1 0 1 1 1 0 PT repeat DUF4704 PF15787.5 ETO16701.1 - 4.5e-09 36.0 5.2 0.00014 21.3 1.8 3.5 3 2 0 3 3 3 2 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 ETO16701.1 - 1.7e-07 31.5 0.0 4.4e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BUD22 PF09073.10 ETO16701.1 - 0.00068 19.1 12.0 0.0012 18.3 12.0 1.3 1 0 0 1 1 1 1 BUD22 PTPRCAP PF15713.5 ETO16701.1 - 0.033 14.5 11.9 0.079 13.3 11.9 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated TFIIA PF03153.13 ETO16701.1 - 0.089 12.8 14.2 0.16 12.0 14.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 ETO16701.1 - 1.2 7.2 21.4 2 6.5 21.4 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO16701.1 - 3.2 7.1 24.3 6.4 6.1 24.3 1.4 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 ETO16701.1 - 5.4 6.2 28.0 12 5.1 28.0 1.6 1 0 0 1 1 1 0 NOA36 protein NPR3 PF03666.13 ETO16701.1 - 9.9 4.8 14.0 50 2.5 12.5 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Lin-8 PF03353.15 ETO16702.1 - 0.023 14.3 0.4 0.031 13.8 0.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist HTH_54 PF18607.1 ETO16702.1 - 0.11 12.6 0.1 0.22 11.6 0.1 1.5 1 0 0 1 1 1 0 ParA helix turn helix domain Sulfatase PF00884.23 ETO16703.1 - 5e-44 150.9 5.5 5.6e-44 150.8 4.2 1.7 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 ETO16703.1 - 0.033 13.8 8.4 0.057 13.0 3.9 3.1 2 1 0 2 2 2 0 Type I phosphodiesterase / nucleotide pyrophosphatase TetR_C_8 PF14278.6 ETO16703.1 - 0.11 12.6 0.9 0.28 11.3 0.1 2.2 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region WD40 PF00400.32 ETO16705.1 - 3.7e-13 49.7 0.9 0.00011 22.9 0.2 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat eIF2A PF08662.11 ETO16705.1 - 0.001 19.0 0.0 0.0021 17.9 0.0 1.4 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ETO16705.1 - 0.0034 17.7 0.0 3.4 8.0 0.0 2.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ETO16705.1 - 0.0088 14.6 0.0 0.044 12.3 0.0 1.7 1 1 1 2 2 2 2 Cytochrome D1 heme domain Utp8 PF10395.9 ETO16705.1 - 0.1 11.1 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Utp8 family WD40 PF00400.32 ETO16706.1 - 3.2e-61 201.8 14.2 1.3e-08 35.3 0.7 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16706.1 - 1.3e-20 73.4 6.9 0.0023 18.2 0.0 7.6 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16706.1 - 8.2e-15 54.6 7.9 0.00061 18.9 0.1 7.0 2 1 4 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO16706.1 - 2.4e-08 33.1 14.0 0.06 12.0 1.0 5.7 3 1 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16706.1 - 5e-08 32.6 5.0 0.00061 19.2 0.0 4.4 2 1 3 5 5 5 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO16706.1 - 2.2e-06 26.5 6.6 0.011 14.3 0.1 3.9 2 1 1 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO16706.1 - 5.6e-05 23.0 3.5 9.3 6.3 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO16706.1 - 0.0026 17.8 1.7 3.9 7.6 0.1 4.1 2 1 3 5 5 5 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO16706.1 - 0.0078 15.6 2.3 0.79 9.0 0.1 3.7 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Read-through PF16814.5 ETO16706.1 - 0.014 15.2 1.4 1.1 9.0 0.0 3.7 3 2 1 4 4 4 0 Read-through domain MIase PF02426.16 ETO16706.1 - 0.078 13.1 0.8 1.1e+02 3.0 0.0 4.8 7 0 0 7 7 7 0 Muconolactone delta-isomerase PQQ PF01011.21 ETO16706.1 - 0.095 12.7 0.0 1 9.4 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat SpoIIIAH PF12685.7 ETO16707.1 - 0.003 17.4 0.1 0.0032 17.3 0.1 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein TssO PF17561.2 ETO16707.1 - 0.0074 16.4 0.1 0.01 15.9 0.1 1.2 1 0 0 1 1 1 1 Type VI secretion system, TssO SIT PF15330.6 ETO16707.1 - 0.0092 16.4 0.1 0.013 16.0 0.1 1.2 1 0 0 1 1 1 1 SHP2-interacting transmembrane adaptor protein, SIT OAD_gamma PF04277.13 ETO16707.1 - 0.012 16.2 0.0 0.026 15.1 0.0 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain FixQ PF05545.11 ETO16707.1 - 0.012 15.5 0.0 0.021 14.8 0.0 1.3 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ V_ATPase_I PF01496.19 ETO16707.1 - 0.02 12.9 0.2 0.021 12.8 0.2 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DAG_kinase_N PF14513.6 ETO16707.1 - 0.066 13.4 0.8 0.083 13.1 0.8 1.1 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Tmp39 PF10271.9 ETO16707.1 - 0.067 12.2 0.0 0.078 12.0 0.0 1.0 1 0 0 1 1 1 0 Putative transmembrane protein DUF2681 PF10883.8 ETO16707.1 - 0.077 13.4 0.2 0.1 13.0 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) DUF3810 PF12725.7 ETO16707.1 - 0.081 12.3 0.0 0.088 12.1 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) SID-1_RNA_chan PF13965.6 ETO16707.1 - 0.11 10.9 0.2 0.13 10.7 0.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Presenilin PF01080.17 ETO16707.1 - 0.12 11.1 0.7 0.14 10.9 0.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETO16707.1 - 0.13 13.3 0.5 0.24 12.4 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Comm PF15957.5 ETO16707.1 - 0.15 12.4 0.2 0.18 12.1 0.2 1.3 1 1 0 1 1 1 0 Commissureless DUF4746 PF15928.5 ETO16707.1 - 1 8.7 5.8 1.3 8.4 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) TMEM154 PF15102.6 ETO16707.1 - 4.6 7.1 7.6 3.4 7.6 3.2 2.0 1 1 1 2 2 2 0 TMEM154 protein family THF_DHG_CYH PF00763.23 ETO16708.1 - 8.7e-10 38.9 0.0 1.1e-09 38.6 0.0 1.1 1 0 0 1 1 1 1 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain YqgF PF14639.6 ETO16708.1 - 0.025 14.3 0.1 0.03 14.1 0.1 1.1 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 WD40 PF00400.32 ETO16709.1 - 1.8e-05 25.4 2.3 2.2e-05 25.1 0.2 2.1 2 1 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO16710.1 - 1.2e-10 41.7 11.7 0.00024 21.8 0.1 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO16710.1 - 0.0022 16.8 1.6 0.0046 15.8 0.6 1.9 1 1 1 2 2 2 1 Nup133 N terminal like Nup160 PF11715.8 ETO16710.1 - 0.0035 16.0 0.7 4 6.0 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16710.1 - 0.061 13.6 0.0 15 6.0 0.0 2.8 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RRM_1 PF00076.22 ETO16711.1 - 0.0072 16.1 0.0 0.013 15.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2487 PF10673.9 ETO16711.1 - 0.071 13.1 1.1 5.9 6.9 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2487) RPAP3_C PF13877.6 ETO16712.1 - 0.071 13.7 0.7 0.12 13.0 0.7 1.4 1 1 0 1 1 1 0 Potential Monad-binding region of RPAP3 AAA_18 PF13238.6 ETO16712.1 - 0.11 13.0 1.0 0.13 12.8 1.0 1.1 1 0 0 1 1 1 0 AAA domain RCC1 PF00415.18 ETO16713.1 - 2.7e-23 82.3 8.4 4.4e-06 27.2 0.0 5.7 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO16713.1 - 6.5e-14 51.3 5.1 0.027 14.3 0.0 5.4 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat Porph_ging PF09697.10 ETO16713.1 - 0.23 12.0 1.1 0.61 10.7 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (Porph_ging) DUF3464 PF11947.8 ETO16714.1 - 0.0042 16.8 0.1 0.058 13.1 0.1 2.0 1 1 0 1 1 1 1 Photosynthesis affected mutant 68 B277 PF17623.2 ETO16714.1 - 0.065 12.3 0.3 0.081 12.0 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function Presenilin PF01080.17 ETO16714.1 - 0.21 10.3 0.3 0.25 10.1 0.3 1.1 1 0 0 1 1 1 0 Presenilin Kelch_6 PF13964.6 ETO16715.1 - 0.018 15.3 0.1 0.21 11.9 0.0 2.5 3 0 0 3 3 3 0 Kelch motif HEAT_2 PF13646.6 ETO16717.1 - 6e-31 106.7 18.9 1.1e-08 35.4 0.3 5.5 1 1 5 6 6 6 6 HEAT repeats HEAT PF02985.22 ETO16717.1 - 2e-15 55.5 5.5 0.4 11.1 0.1 9.0 8 0 0 8 8 8 5 HEAT repeat Cnd1 PF12717.7 ETO16717.1 - 4e-09 36.7 12.7 0.036 14.1 0.0 5.3 3 1 1 5 5 5 3 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETO16717.1 - 2.1e-08 34.3 5.4 0.033 14.4 0.1 5.3 1 1 3 4 4 4 3 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO16717.1 - 0.00013 22.4 18.4 5.4 8.0 0.2 6.4 6 0 0 6 6 6 3 PBS lyase HEAT-like repeat GCV_T PF01571.21 ETO16717.1 - 0.033 13.6 0.3 1.6 8.1 0.0 2.3 2 0 0 2 2 2 0 Aminomethyltransferase folate-binding domain ILEI PF15711.5 ETO16717.1 - 0.54 10.8 2.3 45 4.6 0.1 4.2 4 0 0 4 4 4 0 Interleukin-like EMT inducer HEAT_EZ PF13513.6 ETO16717.1 - 0.66 10.5 13.1 10 6.8 0.1 5.9 5 2 2 7 7 7 0 HEAT-like repeat Mqo PF06039.15 ETO16718.1 - 0.012 14.2 0.6 0.014 13.9 0.6 1.0 1 0 0 1 1 1 0 Malate:quinone oxidoreductase (Mqo) zf-CCCH_6 PF18585.1 ETO16718.1 - 0.077 12.9 0.4 0.26 11.2 0.1 2.0 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 2 WD40 PF00400.32 ETO16719.1 - 2.6e-16 59.7 9.6 2.7e-08 34.3 0.1 5.4 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16719.1 - 1.6e-08 34.8 2.1 0.0034 17.6 0.2 3.6 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16719.1 - 0.00039 19.8 2.8 0.00042 19.7 1.1 1.9 2 0 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 ETO16719.1 - 0.00066 18.7 0.2 1.5 7.7 0.0 3.7 2 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO16719.1 - 0.00068 19.5 0.1 0.39 10.7 0.0 3.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Plk4_PB1 PF18190.1 ETO16719.1 - 0.023 14.9 0.1 1.1 9.4 0.0 3.0 2 1 2 4 4 4 0 Polo-like Kinase 4 Polo Box 1 Nup160 PF11715.8 ETO16719.1 - 0.22 10.1 6.0 0.13 10.8 0.3 2.7 2 1 1 3 3 3 0 Nucleoporin Nup120/160 COX5B PF01215.19 ETO16720.1 - 3.2e-09 36.6 0.0 4.2e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase subunit Vb zf-CHCC PF10276.9 ETO16720.1 - 0.003 17.6 0.9 0.0058 16.7 0.9 1.5 1 0 0 1 1 1 1 Zinc-finger domain DUF1682 PF07946.14 ETO16721.1 - 0.0012 18.1 10.3 0.003 16.8 10.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1682) DUF5523 PF17661.1 ETO16721.1 - 0.0084 15.8 13.5 0.0084 15.8 13.5 3.1 2 1 0 3 3 3 1 Family of unknown function (DUF5523) Med19 PF10278.9 ETO16721.1 - 0.014 15.3 8.2 0.014 15.3 8.2 2.9 3 0 0 3 3 3 0 Mediator of RNA pol II transcription subunit 19 FYDLN_acid PF09538.10 ETO16721.1 - 6.4 7.5 28.1 0.44 11.3 10.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) EMC3_TMCO1 PF01956.16 ETO16721.1 - 9.9 5.9 6.9 20 4.9 6.9 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like WD40 PF00400.32 ETO16722.1 - 1.5e-40 136.4 20.7 9.6e-09 35.7 0.1 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat TFIID_NTD2 PF04494.15 ETO16722.1 - 5.5e-17 62.2 3.5 5.5e-17 62.2 3.5 2.8 2 1 0 2 2 2 1 WD40 associated region in TFIID subunit, NTD2 domain ANAPC4_WD40 PF12894.7 ETO16722.1 - 1.3e-16 60.7 1.1 8.1e-05 22.8 0.0 5.7 4 3 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16722.1 - 8.7e-05 22.0 0.1 0.015 14.6 0.0 2.8 3 0 0 3 3 3 2 WD40-like domain SGL PF08450.12 ETO16722.1 - 0.016 14.8 0.1 0.1 12.2 0.0 2.0 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region WD40 PF00400.32 ETO16723.1 - 9.8e-30 102.2 9.1 2.5e-07 31.3 0.1 5.9 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16723.1 - 4.2e-10 39.8 3.0 2e-06 28.0 0.0 3.9 4 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 ETO16723.1 - 0.0015 17.6 0.4 0.0015 17.6 0.4 1.5 2 0 0 2 2 2 1 Coatomer WD associated region Nup160 PF11715.8 ETO16723.1 - 0.0022 16.8 7.8 0.052 12.2 0.7 3.2 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO16723.1 - 0.037 12.8 2.9 3.4 6.3 0.0 3.4 1 1 3 4 4 4 0 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO16724.1 - 1.2e-83 281.6 1.6 1.5e-83 281.3 1.6 1.1 1 0 0 1 1 1 1 Coatomer WD associated region LisH PF08513.11 ETO16724.1 - 0.13 12.2 0.0 0.61 10.1 0.0 2.0 2 0 0 2 2 2 0 LisH COPI_C PF06957.11 ETO16725.1 - 1.6e-54 185.3 0.6 1.7e-54 185.1 0.6 1.0 1 0 0 1 1 1 1 Coatomer (COPI) alpha subunit C-terminus RSS_P20 PF11757.8 ETO16725.1 - 0.094 13.2 0.1 60 4.2 0.0 3.3 3 1 1 4 4 4 0 Suppressor of RNA silencing P21-like N-terminal domain UQ_con PF00179.26 ETO16726.1 - 5.1e-52 175.3 0.0 5.1e-52 175.3 0.0 1.5 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme RNA_pol_Rpc4 PF05132.14 ETO16726.1 - 0.0062 17.0 7.7 0.0077 16.7 7.7 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 SET PF00856.28 ETO16726.1 - 0.015 15.7 2.1 0.016 15.6 2.1 1.2 1 0 0 1 1 1 0 SET domain Rrn6 PF10214.9 ETO16726.1 - 0.28 9.6 14.3 0.33 9.4 14.3 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Nucleo_P87 PF07267.11 ETO16726.1 - 0.34 9.7 12.0 0.41 9.5 12.0 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Presenilin PF01080.17 ETO16726.1 - 1.3 7.7 17.9 1.7 7.3 17.9 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO16726.1 - 1.8 7.4 12.8 2.4 7.1 12.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Roughex PF06020.11 ETO16726.1 - 2 7.4 14.3 2.7 7.0 14.3 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Vfa1 PF08432.10 ETO16726.1 - 3.6 7.9 28.9 5.7 7.2 28.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Hid1 PF12722.7 ETO16726.1 - 5.7 4.9 16.3 6.3 4.8 16.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Membralin PF09746.9 ETO16726.1 - 6.1 5.8 5.8 7.4 5.5 5.8 1.2 1 0 0 1 1 1 0 Tumour-associated protein SLC12 PF03522.15 ETO16726.1 - 6.7 5.6 16.3 7.6 5.4 16.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Med19 PF10278.9 ETO16726.1 - 7.1 6.5 22.3 10 6.0 22.3 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Pes-10 PF07149.11 ETO16726.1 - 8.5 5.3 17.5 11 5.0 17.5 1.1 1 0 0 1 1 1 0 Pes-10 DDHD PF02862.17 ETO16726.1 - 8.9 6.4 13.3 13 5.9 13.3 1.2 1 0 0 1 1 1 0 DDHD domain VIR_N PF15912.5 ETO16726.1 - 9.3 5.8 17.9 16 5.0 17.9 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal RNA_polI_A34 PF08208.11 ETO16726.1 - 9.3 6.3 29.9 11 6.0 29.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3857 PF12969.7 ETO16727.1 - 0.062 13.4 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3857) RCC1 PF00415.18 ETO16728.1 - 2.5e-09 37.6 0.2 4.4e-08 33.6 0.0 2.3 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO16728.1 - 0.0066 16.2 2.7 0.0066 16.2 2.7 2.7 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO16729.1 - 2.3e-14 53.7 7.6 2.9e-06 27.8 0.0 4.7 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO16729.1 - 2.3e-09 36.8 13.3 0.00036 20.3 0.5 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat zf-rbx1 PF12678.7 ETO16729.1 - 0.019 15.2 0.9 0.19 12.1 0.2 2.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain CDC45 PF02724.14 ETO16730.1 - 0.26 9.5 6.6 0.31 9.3 6.6 1.2 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO16731.1 - 3.2e-19 68.9 1.0 3.5e-06 27.6 0.0 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO16731.1 - 0.0035 16.1 3.2 0.17 10.5 0.1 2.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO16731.1 - 0.0041 17.4 0.2 1.3 9.4 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain RAG1_imp_bd PF12560.8 ETO16731.1 - 0.063 12.8 0.5 0.11 12.1 0.5 1.3 1 0 0 1 1 1 0 RAG1 importin binding Dehydrin PF00257.19 ETO16731.1 - 1.3 9.5 3.4 1.6 9.3 0.1 2.3 2 1 0 2 2 2 0 Dehydrin Ammonium_transp PF00909.21 ETO16732.1 - 6.4e-32 110.7 1.2 7.8e-32 110.5 1.2 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Ank_4 PF13637.6 ETO16732.1 - 0.051 14.2 0.5 0.18 12.4 0.1 2.1 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Yip1 PF04893.17 ETO16732.1 - 0.091 12.5 7.1 0.21 11.3 7.1 1.5 1 0 0 1 1 1 0 Yip1 domain Phage_holin_5_2 PF16079.5 ETO16732.1 - 0.26 11.6 2.9 3.2 8.1 0.2 3.0 2 1 1 3 3 3 0 Phage holin family Hol44, in holin superfamily V ART PF01129.18 ETO16733.1 - 0.0013 18.1 0.1 0.0021 17.4 0.1 1.3 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase CTP_transf_3 PF02348.19 ETO16733.1 - 0.031 14.2 0.7 0.062 13.2 0.1 1.9 2 1 0 2 2 2 0 Cytidylyltransferase DUF5517 PF17639.2 ETO16733.1 - 1.5 9.1 5.7 3.8 7.9 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5517) SH3_9 PF14604.6 ETO16734.1 - 1.8e-13 50.1 0.3 2.7e-13 49.5 0.3 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ETO16734.1 - 5e-13 48.4 0.1 8.7e-13 47.7 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETO16734.1 - 5.1e-07 29.3 0.0 8e-07 28.7 0.0 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ETO16734.1 - 0.012 15.9 0.7 0.019 15.3 0.7 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain FAM176 PF14851.6 ETO16734.1 - 3.3 7.4 8.2 4.8 6.8 8.2 1.2 1 0 0 1 1 1 0 FAM176 family BLYB PF05289.11 ETO16736.1 - 0.0016 18.6 1.6 0.0018 18.5 1.6 1.1 1 0 0 1 1 1 1 Borrelia hemolysin accessory protein FPRL1_inhibitor PF16104.5 ETO16736.1 - 0.017 15.3 0.6 0.021 14.9 0.6 1.2 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein Imm41 PF15592.6 ETO16736.1 - 0.091 13.1 0.3 0.15 12.4 0.3 1.6 1 1 0 1 1 1 0 Immunity protein 41 Ion_trans PF00520.31 ETO16738.1 - 2.6e-11 43.2 0.0 3.9e-11 42.6 0.0 1.3 1 1 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO16738.1 - 0.023 13.4 0.1 0.026 13.2 0.1 1.1 1 0 0 1 1 1 0 Polycystin cation channel WD40 PF00400.32 ETO16739.1 - 1e-21 76.8 19.7 2.5e-07 31.3 1.9 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16739.1 - 5.5e-06 26.6 0.2 0.34 11.2 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16739.1 - 6.5e-06 25.1 3.9 0.026 13.2 0.3 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16739.1 - 0.00056 19.3 1.2 0.0055 16.1 0.6 2.3 1 1 2 3 3 3 1 WD40-like domain SH3_13 PF18335.1 ETO16739.1 - 0.13 12.1 1.5 10 6.0 0.3 3.1 2 1 1 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain DUF678 PF05077.12 ETO16739.1 - 0.15 12.2 0.3 1.6 9.0 0.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF678) WD40 PF00400.32 ETO16740.1 - 2.7e-25 88.1 14.7 5.1e-07 30.3 1.5 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16740.1 - 1.4e-08 34.9 0.1 0.0049 17.2 0.0 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16740.1 - 3.5e-07 29.3 0.9 0.048 12.3 0.1 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16740.1 - 5.1e-06 26.0 1.6 0.1 11.9 0.3 2.9 1 1 2 3 3 3 3 WD40-like domain PH PF00169.29 ETO16741.1 - 1.1e-10 42.0 1.0 1.8e-10 41.2 0.4 1.7 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ETO16741.1 - 0.0083 16.2 0.0 0.017 15.2 0.0 1.5 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO16741.1 - 0.036 14.4 0.2 0.074 13.3 0.2 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain DUF4667 PF15700.5 ETO16742.1 - 0.036 14.2 8.7 0.043 13.9 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) CCDC106 PF15794.5 ETO16742.1 - 1.1 8.9 7.6 1.7 8.3 7.6 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Apt1 PF10351.9 ETO16742.1 - 1.3 7.8 6.1 1.3 7.8 6.1 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain AF-4 PF05110.13 ETO16742.1 - 2 6.4 17.9 2.4 6.1 17.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Macoilin PF09726.9 ETO16742.1 - 2.2 6.7 10.2 2.6 6.5 10.2 1.1 1 0 0 1 1 1 0 Macoilin family RAP1 PF07218.11 ETO16742.1 - 4.1 5.5 14.3 5.3 5.2 14.3 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) PAP1 PF08601.10 ETO16742.1 - 4.2 7.0 16.2 5.2 6.7 16.2 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 SOG2 PF10428.9 ETO16742.1 - 5.8 6.0 15.6 7 5.7 15.6 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein TonB_N PF16031.5 ETO16742.1 - 6.6 7.3 9.2 1.9 9.0 6.5 1.6 2 0 0 2 2 2 0 TonB polyproline region His_Phos_2 PF00328.22 ETO16743.1 - 2.6e-08 33.6 0.5 6.9e-08 32.2 0.5 1.6 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) PXA PF02194.15 ETO16744.1 - 0.068 13.1 0.4 2.3 8.2 0.2 2.1 2 0 0 2 2 2 0 PXA domain Pkinase PF00069.25 ETO16745.1 - 1e-15 57.9 0.4 2.5e-09 36.9 1.0 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16745.1 - 9.6e-06 25.1 0.1 2.9e-05 23.5 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO16745.1 - 1.7e-05 23.8 1.6 8.1e-05 21.6 0.1 2.1 2 0 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ETO16745.1 - 0.00044 20.2 0.0 0.00082 19.4 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Bromo_TP PF07524.13 ETO16745.1 - 0.16 12.0 0.0 25 5.0 0.0 2.5 2 0 0 2 2 2 0 Bromodomain associated DUF4604 PF15377.6 ETO16747.1 - 0.58 10.6 18.9 0.68 10.3 18.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) PSCyt3 PF07627.11 ETO16747.1 - 0.73 10.1 4.7 0.47 10.8 2.3 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) SLC12 PF03522.15 ETO16747.1 - 2.9 6.8 14.3 3.4 6.6 14.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 WD40 PF00400.32 ETO16748.1 - 3.1e-128 413.9 53.7 6e-09 36.4 0.3 16.3 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16748.1 - 7.9e-24 83.8 19.5 0.11 12.8 0.0 13.0 1 1 13 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16748.1 - 2.4e-20 72.8 7.6 0.0082 15.1 0.0 12.2 1 1 13 15 15 15 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO16748.1 - 3.1e-11 43.2 15.8 0.0015 18.0 0.0 7.3 2 2 4 7 7 7 4 WD40-like domain Pentapeptide PF00805.22 ETO16748.1 - 8e-06 25.4 2.0 2.1e-05 24.0 2.0 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO16748.1 - 4.6e-05 23.2 4.2 24 5.0 0.0 7.1 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Mid2 PF04478.12 ETO16748.1 - 5.7e-05 23.0 9.4 3.6 7.4 0.2 7.6 4 2 5 9 9 9 2 Mid2 like cell wall stress sensor Pentapeptide_4 PF13599.6 ETO16748.1 - 0.00017 21.7 0.1 0.00045 20.3 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) POLO_box PF00659.18 ETO16748.1 - 0.00035 20.7 8.2 15 5.9 0.0 8.4 10 1 0 10 10 10 1 POLO box duplicated region Pentapeptide_3 PF13576.6 ETO16748.1 - 0.02 15.1 0.3 0.06 13.5 0.3 1.8 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) P2 PF07194.11 ETO16748.1 - 0.12 12.4 0.1 1.2 9.2 0.1 2.4 2 0 0 2 2 2 0 P2 response regulator binding domain CsgF PF10614.9 ETO16748.1 - 0.21 11.8 3.2 20 5.4 0.1 4.5 2 1 1 3 3 3 0 Type VIII secretion system (T8SS), CsgF protein La PF05383.17 ETO16749.1 - 6.9e-06 26.0 0.0 4e-05 23.6 0.0 2.2 2 0 0 2 2 2 1 La domain Atg14 PF10186.9 ETO16749.1 - 3.8 6.5 15.7 6.2 5.8 15.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4404 PF14357.6 ETO16749.1 - 8 7.2 14.3 0.3 11.8 5.9 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) Exonuc_VII_L PF02601.15 ETO16749.1 - 8.4 5.9 12.9 11 5.4 12.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PEARLI-4 PF05278.12 ETO16750.1 - 0.026 14.1 4.4 0.046 13.3 4.4 1.4 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) DUF2304 PF10066.9 ETO16750.1 - 1.3 9.2 3.6 13 6.1 0.1 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) TSC22 PF01166.18 ETO16750.1 - 2.4 8.5 9.6 0.67 10.3 2.4 2.8 2 1 0 2 2 2 0 TSC-22/dip/bun family DHR10 PF18595.1 ETO16750.1 - 8.4 6.5 18.5 1.4 9.0 13.1 2.4 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain DUF2663 PF10864.8 ETO16752.1 - 0.0098 16.3 1.8 0.0098 16.3 1.8 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2663) Suf PF05843.14 ETO16754.1 - 4.7 7.1 18.2 2.4 8.1 16.0 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) DUF4375 PF14300.6 ETO16757.1 - 0.00069 19.9 1.7 0.00099 19.4 1.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4375) DUF4878 PF12870.7 ETO16757.1 - 0.006 16.9 3.2 0.0067 16.7 2.8 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4878) Prok-TraM PF09228.10 ETO16757.1 - 0.081 13.3 1.8 0.12 12.8 0.6 1.9 1 1 0 1 1 1 0 Prokaryotic Transcriptional repressor TraM RMMBL PF07521.12 ETO16758.1 - 5.9e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Peptidase_U57 PF05582.12 ETO16758.1 - 0.044 13.0 0.4 0.044 13.0 0.4 2.8 3 0 0 3 3 3 0 YabG peptidase U57 Voltage_CLC PF00654.20 ETO16759.1 - 5e-12 45.7 9.3 6.4e-11 42.1 0.5 3.0 2 1 1 3 3 3 3 Voltage gated chloride channel FAM176 PF14851.6 ETO16759.1 - 0.022 14.5 0.9 0.041 13.5 0.9 1.4 1 0 0 1 1 1 0 FAM176 family Voltage_CLC PF00654.20 ETO16760.1 - 8.8e-24 84.4 1.8 1.1e-23 84.1 1.8 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel Orf78 PF06024.12 ETO16760.1 - 0.15 12.4 2.5 1.5 9.2 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) SNARE_assoc PF09335.11 ETO16760.1 - 0.26 11.8 7.3 0.62 10.6 0.2 2.4 2 0 0 2 2 2 0 SNARE associated Golgi protein zf-LITAF-like PF10601.9 ETO16760.1 - 2.7 8.3 7.2 2.1 8.7 1.1 3.0 3 0 0 3 3 3 0 LITAF-like zinc ribbon domain MA3 PF02847.17 ETO16761.1 - 0.0034 17.4 0.8 0.0083 16.1 0.1 2.0 2 0 0 2 2 2 1 MA3 domain CdvA PF18822.1 ETO16761.1 - 0.017 15.0 0.4 0.043 13.6 0.4 1.7 2 0 0 2 2 2 0 CdvA-like coiled-coil domain RepB-RCR_reg PF10723.9 ETO16761.1 - 0.034 14.1 0.4 0.21 11.5 0.2 2.3 2 0 0 2 2 2 0 Replication regulatory protein RepB TetR_C_19 PF17924.1 ETO16762.1 - 0.083 13.5 1.0 0.16 12.6 1.0 1.5 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Ribosomal_60s PF00428.19 ETO16762.1 - 0.9 10.2 9.8 1.5 9.5 8.2 2.1 3 0 0 3 3 3 0 60s Acidic ribosomal protein STAS PF01740.21 ETO16763.1 - 1e-19 70.3 0.1 1.7e-19 69.6 0.1 1.4 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO16763.1 - 5e-05 22.2 4.4 5e-05 22.2 4.4 2.1 3 0 0 3 3 3 1 Sulfate permease family ATG7_N PF16420.5 ETO16763.1 - 0.02 14.6 0.4 0.028 14.1 0.4 1.2 1 0 0 1 1 1 0 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus Methyltransf_3 PF01596.17 ETO16764.1 - 1.6e-56 190.9 0.5 1.9e-56 190.6 0.5 1.1 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ETO16764.1 - 6.8e-13 49.6 0.0 7.6e-12 46.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO16764.1 - 1.9e-05 24.5 0.1 2.9e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO16764.1 - 6.2e-05 23.6 0.0 0.00013 22.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETO16764.1 - 0.0013 18.1 0.0 0.0018 17.7 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_18 PF12847.7 ETO16764.1 - 0.021 14.7 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_11 PF08241.12 ETO16764.1 - 0.025 15.2 0.0 0.058 14.0 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 ETO16764.1 - 0.034 13.5 0.0 0.046 13.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GCD14 PF08704.10 ETO16764.1 - 0.087 12.5 0.0 0.15 11.7 0.0 1.4 1 1 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit HsbA PF12296.8 ETO16765.1 - 0.21 12.1 3.2 0.16 12.4 1.4 1.6 2 0 0 2 2 2 0 Hydrophobic surface binding protein A GAPES4 PF17157.4 ETO16766.1 - 0.043 14.2 0.1 0.087 13.2 0.1 1.5 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain PH_12 PF16457.5 ETO16767.1 - 3.3e-08 34.1 0.2 5.5e-08 33.4 0.2 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_14 PF17787.1 ETO16767.1 - 9.6e-05 22.2 0.3 0.00036 20.4 0.2 1.9 1 1 0 1 1 1 1 PH domain PH PF00169.29 ETO16767.1 - 0.066 13.7 2.0 0.25 11.9 2.0 1.9 1 1 0 1 1 1 0 PH domain CzcE PF16986.5 ETO16767.1 - 0.09 13.1 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Heavy-metal resistance protein CzcE Mcp5_PH PF12814.7 ETO16767.1 - 0.095 12.8 0.3 0.15 12.2 0.1 1.5 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology WD40 PF00400.32 ETO16768.1 - 5.3e-25 87.2 15.8 1.9e-06 28.5 1.2 5.7 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16768.1 - 6e-09 36.1 1.0 0.018 15.3 0.0 4.5 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO16768.1 - 4.1e-07 30.6 1.1 4.1e-07 30.6 1.1 2.7 2 1 0 2 2 2 1 TRAF-type zinc finger Nup160 PF11715.8 ETO16768.1 - 1.7e-05 23.7 11.9 0.19 10.3 0.3 5.1 3 2 2 6 6 6 4 Nucleoporin Nup120/160 Orbi_VP5 PF00901.17 ETO16768.1 - 0.0097 14.3 2.2 0.016 13.6 2.2 1.3 1 0 0 1 1 1 1 Orbivirus outer capsid protein VP5 Arm PF00514.23 ETO16769.1 - 0.013 15.5 1.2 6.3 7.0 0.2 2.6 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat Arm PF00514.23 ETO16770.1 - 8e-14 51.1 1.0 0.0011 18.9 0.1 4.7 5 0 0 5 5 5 4 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO16770.1 - 0.056 14.0 0.0 11 6.6 0.0 3.2 4 0 0 4 4 4 0 HEAT-like repeat HEAT_2 PF13646.6 ETO16773.1 - 3.8e-07 30.4 0.1 2.5e-05 24.6 0.0 2.4 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO16773.1 - 0.013 15.7 0.0 3.4 8.2 0.0 3.2 3 0 0 3 3 3 0 HEAT repeat ArsC PF03960.15 ETO16774.1 - 0.14 12.2 0.0 0.39 10.8 0.0 1.8 1 1 0 1 1 1 0 ArsC family HATPase_c PF02518.26 ETO16775.1 - 4.4e-08 33.6 0.0 6e-08 33.2 0.0 1.1 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO16775.1 - 5.2e-05 23.1 0.0 7e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase zf_C2H2_13 PF18508.1 ETO16776.1 - 0.0016 18.0 0.4 0.0041 16.7 0.4 1.7 1 0 0 1 1 1 1 Zinc finger domain Fez1 PF06818.15 ETO16776.1 - 0.0023 18.4 1.0 0.0034 17.9 1.0 1.3 1 0 0 1 1 1 1 Fez1 PKcGMP_CC PF16808.5 ETO16776.1 - 0.0085 15.9 4.7 0.0085 15.9 4.7 2.7 2 0 0 2 2 2 1 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4094 PF13334.6 ETO16776.1 - 0.045 14.2 1.4 0.1 13.0 1.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) DUF4349 PF14257.6 ETO16776.1 - 0.07 12.6 0.8 0.1 12.0 0.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) DUF641 PF04859.12 ETO16776.1 - 0.14 12.5 2.6 0.28 11.5 2.6 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) Cep57_MT_bd PF06657.13 ETO16776.1 - 0.25 11.8 3.4 0.62 10.6 2.9 1.9 1 1 0 1 1 1 0 Centrosome microtubule-binding domain of Cep57 FANCL_C PF11793.8 ETO16776.1 - 0.75 10.0 4.5 0.29 11.3 0.6 2.3 2 1 0 2 2 2 0 FANCL C-terminal domain WD40 PF00400.32 ETO16777.1 - 9.8e-37 124.3 23.0 1.9e-06 28.4 1.9 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16777.1 - 5.8e-13 49.0 2.2 0.0022 18.3 0.0 5.3 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16777.1 - 2e-10 39.9 5.8 0.0062 15.2 0.0 5.1 3 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16777.1 - 7e-07 28.9 9.7 0.0081 15.5 0.4 4.9 2 2 2 5 5 5 3 WD40-like domain CAP_GLY PF01302.25 ETO16778.1 - 1e-09 38.2 1.2 8.8e-08 32.1 1.2 2.2 1 1 0 1 1 1 1 CAP-Gly domain GIT_CC PF16559.5 ETO16778.1 - 1.7 8.6 7.7 6.8 6.6 1.0 2.3 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor PBP5_C PF07943.13 ETO16779.1 - 0.049 13.9 0.2 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 Penicillin-binding protein 5, C-terminal domain RGS PF00615.19 ETO16781.1 - 8.9e-06 26.0 2.9 3.1e-05 24.2 0.1 2.8 2 1 1 3 3 3 1 Regulator of G protein signaling domain DUF2397 PF09660.10 ETO16782.1 - 0.0022 17.0 0.3 0.0044 16.0 0.3 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2397) IFT46_B_C PF12317.8 ETO16782.1 - 2 8.1 4.7 0.93 9.2 1.5 2.0 2 0 0 2 2 2 0 Intraflagellar transport complex B protein 46 C terminal Focal_AT PF03623.13 ETO16783.1 - 0.0032 17.5 0.8 0.0037 17.3 0.8 1.2 1 0 0 1 1 1 1 Focal adhesion targeting region HECA PF15353.6 ETO16783.1 - 0.06 13.6 0.1 0.15 12.3 0.0 1.6 1 1 0 2 2 2 0 Headcase protein family homologue Peptidase_M16 PF00675.20 ETO16783.1 - 0.067 13.2 0.0 0.082 12.9 0.0 1.1 1 0 0 1 1 1 0 Insulinase (Peptidase family M16) PAD_M PF08527.10 ETO16786.1 - 0.0016 18.2 1.8 0.085 12.5 0.7 2.6 2 0 0 2 2 2 2 Protein-arginine deiminase (PAD) middle domain KH_1 PF00013.29 ETO16786.1 - 0.0023 17.7 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 KH domain IQCJ-SCHIP1 PF15157.6 ETO16787.1 - 0.031 14.1 1.4 0.053 13.4 1.4 1.4 1 0 0 1 1 1 0 Fusion protein IQCJ-SCHIP1 with IQ-like motif CCDC24 PF15669.5 ETO16787.1 - 0.069 13.0 0.9 0.092 12.6 0.9 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family ALMT PF11744.8 ETO16788.1 - 0.56 9.0 6.3 0.7 8.7 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Sec62 PF03839.16 ETO16788.1 - 1.1 8.7 6.3 1.4 8.4 6.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO16788.1 - 1.4 7.6 7.0 1.6 7.4 7.0 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO16788.1 - 4 5.6 11.9 5 5.3 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Ctr PF04145.15 ETO16788.1 - 6 7.5 5.1 18 5.9 5.1 1.7 1 1 0 1 1 1 0 Ctr copper transporter family ETRAMP PF09716.10 ETO16790.1 - 0.062 13.4 1.4 0.076 13.1 1.4 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3655 PF12379.8 ETO16790.1 - 0.16 12.3 4.2 0.15 12.4 3.4 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3655) Serpin PF00079.20 ETO16790.1 - 0.24 10.7 2.2 0.25 10.6 2.2 1.0 1 0 0 1 1 1 0 Serpin (serine protease inhibitor) Chorein_N PF12624.7 ETO16792.1 - 2e-25 89.1 0.9 8.6e-25 87.1 0.0 2.3 2 1 0 2 2 2 1 N-terminal region of Chorein or VPS13 DUF3235 PF11574.8 ETO16792.1 - 0.1 13.5 0.7 2.5 9.0 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3235) Ntox50 PF15542.6 ETO16792.1 - 0.32 11.8 5.0 0.58 11.0 5.0 1.4 1 0 0 1 1 1 0 Bacterial toxin 50 TF_AP-2 PF03299.14 ETO16794.1 - 0.0053 16.8 1.4 0.0066 16.4 1.4 1.2 1 0 0 1 1 1 1 Transcription factor AP-2 ATP-synt_F PF01990.17 ETO16794.1 - 0.12 12.8 0.8 0.15 12.4 0.8 1.3 1 1 0 1 1 1 0 ATP synthase (F/14-kDa) subunit EMC3_TMCO1 PF01956.16 ETO16794.1 - 0.79 9.4 11.0 1.1 9.0 11.0 1.3 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Peptidase_S49_N PF08496.10 ETO16796.1 - 8.1 6.5 9.4 11 6.0 9.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF2167 PF09935.9 ETO16797.1 - 0.05 12.8 0.1 0.072 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2167) PDEase_I PF00233.19 ETO16799.1 - 1.7e-21 77.0 0.0 2.9e-21 76.3 0.0 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Imm39 PF15568.6 ETO16800.1 - 0.01 15.9 0.4 1.5 8.9 0.1 2.1 2 0 0 2 2 2 0 Immunity protein 39 Sec62 PF03839.16 ETO16800.1 - 0.079 12.4 6.5 0.11 12.0 6.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 EOS1 PF12326.8 ETO16800.1 - 0.17 11.8 0.2 0.23 11.4 0.2 1.3 1 0 0 1 1 1 0 N-glycosylation protein Zip PF02535.22 ETO16800.1 - 0.17 11.0 0.4 0.21 10.8 0.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO16800.1 - 0.39 9.4 1.6 0.4 9.4 1.6 1.1 1 0 0 1 1 1 0 Presenilin Pox_P35 PF03213.14 ETO16801.1 - 0.075 12.2 0.3 0.11 11.7 0.3 1.2 1 0 0 1 1 1 0 Poxvirus P35 protein SNF2_N PF00176.23 ETO16802.1 - 2.1e-51 174.7 0.0 3.5e-51 174.0 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO16802.1 - 1.3e-16 60.9 0.1 4.7e-16 59.1 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO16802.1 - 6.4e-08 32.8 5.6 8.9e-08 32.3 0.0 3.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit Orf78 PF06024.12 ETO16802.1 - 0.00011 22.4 0.1 0.00011 22.4 0.1 3.5 3 0 0 3 3 3 1 Orf78 (ac78) Vfa1 PF08432.10 ETO16802.1 - 0.0031 17.9 2.4 0.0031 17.9 2.4 3.4 4 0 0 4 4 3 1 AAA-ATPase Vps4-associated protein 1 ABC2_membrane_3 PF12698.7 ETO16802.1 - 0.0055 15.9 0.0 0.023 13.8 0.0 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein Ni_hydr_CYTB PF01292.20 ETO16802.1 - 0.0089 15.6 0.0 0.039 13.5 0.0 1.9 2 0 0 2 2 2 1 Prokaryotic cytochrome b561 DUF4366 PF14283.6 ETO16802.1 - 0.053 13.6 0.3 0.053 13.6 0.3 2.5 2 0 0 2 2 1 0 Domain of unknown function (DUF4366) RR_TM4-6 PF06459.12 ETO16802.1 - 0.081 12.7 18.1 0.12 12.1 3.7 2.6 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 TMEM132D_C PF15706.5 ETO16802.1 - 0.11 12.3 0.0 0.5 10.2 0.0 2.2 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term DUF4448 PF14610.6 ETO16802.1 - 0.14 11.9 3.2 0.45 10.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) Rad54_N PF08658.10 ETO16802.1 - 5.6 7.1 22.3 0.044 14.0 9.7 3.4 2 1 0 2 2 1 0 Rad54 N terminal CDC45 PF02724.14 ETO16802.1 - 5.8 5.1 15.8 0.016 13.5 0.5 2.3 2 0 0 2 2 2 0 CDC45-like protein PNISR PF15996.5 ETO16802.1 - 7.8 6.7 26.2 0.86 9.9 1.5 3.6 4 0 0 4 4 4 0 Arginine/serine-rich protein PNISR NPR3 PF03666.13 ETO16802.1 - 8.2 5.1 14.0 0.86 8.3 1.1 2.5 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2052 PF09747.9 ETO16802.1 - 9.4 6.3 21.1 1.4 9.0 8.0 2.9 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) dNK PF01712.19 ETO16803.1 - 2.5e-07 30.8 0.7 3.5e-07 30.3 0.7 1.2 1 0 0 1 1 1 1 Deoxynucleoside kinase Cu_amine_oxidN2 PF02727.16 ETO16803.1 - 0.091 13.0 0.0 5.6 7.3 0.0 2.5 2 0 0 2 2 2 0 Copper amine oxidase, N2 domain dNK PF01712.19 ETO16804.1 - 2.8e-05 24.1 0.0 3.2e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_28 PF13521.6 ETO16804.1 - 9.6e-05 22.7 0.0 0.00012 22.4 0.0 1.1 1 0 0 1 1 1 1 AAA domain Thioredoxin PF00085.20 ETO16805.1 - 0.00026 20.9 0.1 0.00068 19.6 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin Pkinase PF00069.25 ETO16806.1 - 7.4e-18 64.8 0.0 9e-18 64.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO16806.1 - 0.0036 16.6 0.0 0.0044 16.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase DUF1363 PF07101.11 ETO16807.1 - 0.033 14.5 0.1 1 9.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1363) LRR_6 PF13516.6 ETO16807.1 - 0.41 10.8 4.3 7.8 6.8 0.4 2.9 2 0 0 2 2 2 0 Leucine Rich repeat LRR_4 PF12799.7 ETO16807.1 - 0.84 10.2 6.0 3.2 8.3 0.3 3.5 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO16807.1 - 1.9 9.4 7.5 1.8 9.4 1.1 3.2 3 0 0 3 3 3 0 Leucine Rich Repeat zf-CCHC_2 PF13696.6 ETO16808.1 - 1.3e-11 44.0 20.3 8e-09 35.2 12.9 2.4 2 0 0 2 2 2 2 Zinc knuckle zf-CCHC PF00098.23 ETO16808.1 - 0.00096 19.1 6.1 0.00096 19.1 6.1 2.3 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_3 PF13917.6 ETO16808.1 - 0.74 9.8 6.6 0.18 11.8 1.6 2.3 2 0 0 2 2 2 0 Zinc knuckle EMP70 PF02990.16 ETO16809.1 - 1.3e-13 50.4 3.3 1.3e-13 50.4 3.3 1.7 1 1 1 2 2 2 1 Endomembrane protein 70 DSPc PF00782.20 ETO16810.1 - 8.1e-06 25.7 0.0 3.1e-05 23.8 0.0 1.7 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain SR-25 PF10500.9 ETO16812.1 - 8.8e-05 22.2 9.5 9.9e-05 22.0 9.5 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCDC106 PF15794.5 ETO16812.1 - 0.16 11.7 9.9 0.21 11.3 9.9 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF3915 PF13054.6 ETO16812.1 - 0.35 10.9 3.7 0.55 10.2 3.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3827 PF12877.7 ETO16812.1 - 2.4 6.4 6.5 2.7 6.3 6.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) CDC45 PF02724.14 ETO16812.1 - 3.9 5.7 11.3 4.3 5.5 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO16812.1 - 7.7 5.2 6.3 8.4 5.0 6.3 1.0 1 0 0 1 1 1 0 Presenilin Pes-10 PF07149.11 ETO16812.1 - 8.4 5.3 9.8 18 4.2 0.0 2.0 2 0 0 2 2 2 0 Pes-10 DUF4614 PF15391.6 ETO16812.1 - 9.2 6.2 10.0 12 5.9 10.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Peptidase_S41_N PF11918.8 ETO16814.1 - 0.027 14.7 0.2 0.052 13.8 0.2 1.5 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP DUF1694 PF07997.11 ETO16814.1 - 0.031 14.4 1.8 1 9.4 0.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1694) Thioredoxin_8 PF13905.6 ETO16815.1 - 0.099 13.0 1.9 20 5.6 0.0 3.0 2 1 1 3 3 3 0 Thioredoxin-like DUF5122 PF17164.4 ETO16816.1 - 6.4e-10 39.2 7.7 0.0027 18.0 0.0 4.3 4 0 0 4 4 4 3 Domain of unknown function (DUF5122) beta-propeller DUF903 PF06004.12 ETO16816.1 - 0.051 13.5 1.6 4.4 7.3 0.0 3.5 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF903) G-alpha PF00503.20 ETO16817.1 - 8.3e-26 91.0 2.5 9.7e-26 90.7 2.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit NodS PF05401.11 ETO16817.1 - 0.042 13.5 0.1 0.078 12.6 0.1 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) EF-hand_7 PF13499.6 ETO16818.1 - 9.2e-12 45.2 2.6 2.7e-08 34.1 1.5 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO16818.1 - 5.6e-10 38.9 2.6 2.1e-07 30.7 0.8 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO16818.1 - 2e-09 36.3 4.6 1e-05 24.7 0.5 3.4 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO16818.1 - 8.2e-09 34.7 3.4 0.0069 16.2 0.3 3.5 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 ETO16818.1 - 7.1e-06 25.3 7.6 0.0014 18.0 0.8 3.7 4 0 0 4 4 4 2 EF hand SPARC_Ca_bdg PF10591.9 ETO16818.1 - 0.017 15.5 1.9 0.08 13.3 0.8 2.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO16818.1 - 0.026 14.5 2.3 0.036 14.0 0.9 1.9 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand T3SS_HrpK1 PF16937.5 ETO16818.1 - 0.027 14.1 0.1 0.054 13.2 0.1 1.4 1 0 0 1 1 1 0 Type III secretion system translocator protein, HrpF Sigma54_CBD PF04963.13 ETO16818.1 - 0.039 13.8 0.2 0.056 13.3 0.2 1.3 1 0 0 1 1 1 0 Sigma-54 factor, core binding domain Dockerin_1 PF00404.18 ETO16818.1 - 0.1 12.8 0.3 0.51 10.6 0.2 2.0 2 0 0 2 2 2 0 Dockerin type I domain PIN_2 PF10130.9 ETO16818.1 - 1.2 9.4 4.4 10 6.4 1.9 2.9 2 1 0 2 2 2 0 PIN domain GPS PF01825.21 ETO16819.1 - 6.3e-09 36.2 3.9 6.3e-09 36.2 3.9 2.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Cys_rich_CPCC PF14206.6 ETO16819.1 - 0.14 12.0 0.1 0.32 10.8 0.1 1.6 1 0 0 1 1 1 0 Cysteine-rich CPCC MIG-14_Wnt-bd PF06664.12 ETO16819.1 - 1.1 8.4 44.1 0.49 9.6 1.5 2.9 1 1 1 2 2 2 0 Wnt-binding factor required for Wnt secretion SlyX PF04102.12 ETO16820.1 - 0.0035 17.9 1.4 0.01 16.5 0.6 2.1 2 0 0 2 2 2 1 SlyX UPF0242 PF06785.11 ETO16820.1 - 0.029 14.5 9.2 1.7 8.7 0.0 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spectrin PF00435.21 ETO16820.1 - 0.16 12.5 5.7 0.35 11.4 5.7 1.8 1 1 0 1 1 1 0 Spectrin repeat DivIC PF04977.15 ETO16820.1 - 2.9 7.7 14.2 3.5 7.5 4.0 3.3 3 0 0 3 3 3 0 Septum formation initiator PocR PF10114.9 ETO16821.1 - 0.019 14.7 0.1 0.052 13.3 0.1 1.7 1 0 0 1 1 1 0 Sensory domain found in PocR Gemini_AL1_M PF08283.11 ETO16821.1 - 0.94 9.6 4.5 1.4 9.1 0.8 2.5 2 0 0 2 2 2 0 Geminivirus rep protein central domain BCAS3 PF12490.8 ETO16822.1 - 0.25 10.9 2.6 0.46 10.0 2.6 1.4 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 3 ABC_membrane PF00664.23 ETO16824.1 - 1.4e-38 133.2 6.5 7.9e-19 68.4 2.1 2.3 1 1 1 2 2 2 2 ABC transporter transmembrane region DUF1840 PF08895.11 ETO16824.1 - 0.12 12.7 1.5 0.27 11.6 1.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) DUF2457 PF10446.9 ETO16825.1 - 0.1 11.7 15.5 0.092 11.9 15.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2052 PF09747.9 ETO16825.1 - 0.14 12.3 9.8 0.13 12.3 9.8 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DUF4637 PF15470.6 ETO16825.1 - 0.52 10.0 9.5 0.49 10.1 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Nop14 PF04147.12 ETO16825.1 - 0.83 7.8 12.6 0.73 8.0 12.6 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO16825.1 - 0.91 8.9 10.6 0.81 9.1 10.6 1.0 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ETO16825.1 - 1.4 8.1 8.9 1.4 8.2 8.9 1.0 1 0 0 1 1 1 0 BUD22 PI3K_1B_p101 PF10486.9 ETO16825.1 - 1.8 6.3 3.6 1.6 6.4 3.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pox_Ag35 PF03286.14 ETO16825.1 - 1.9 8.2 8.8 1.9 8.2 8.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Radial_spoke PF04712.12 ETO16825.1 - 3.9 6.3 11.0 3.3 6.5 11.0 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein CDC45 PF02724.14 ETO16825.1 - 6.7 4.9 10.6 6.3 5.0 10.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO16825.1 - 10 4.1 20.5 10 4.1 20.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi LMBR1 PF04791.16 ETO16826.1 - 0.00021 20.3 8.8 0.00026 20.1 8.8 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF3474 PF11960.8 ETO16826.1 - 4.5 7.5 5.7 2 8.6 2.6 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3474) DUF572 PF04502.13 ETO16827.1 - 0.73 9.4 26.5 0.9 9.1 26.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Pacs-1 PF10254.9 ETO16827.1 - 1.5 7.7 16.7 2.4 7.1 16.7 1.4 1 1 0 1 1 1 0 PACS-1 cytosolic sorting protein Spore_coat_CotO PF14153.6 ETO16827.1 - 9.5 6.1 29.2 0.069 13.1 2.6 2.3 2 0 0 2 2 2 0 Spore coat protein CotO Menin PF05053.13 ETO16828.1 - 0.99 7.7 3.4 1.2 7.4 3.4 1.1 1 0 0 1 1 1 0 Menin DUF2207 PF09972.9 ETO16828.1 - 5.6 5.6 10.5 1.4 7.6 6.9 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) CPSF100_C PF13299.6 ETO16829.1 - 0.061 13.5 5.9 0.085 13.0 5.9 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SURF2 PF05477.11 ETO16829.1 - 0.18 11.4 12.2 0.24 11.1 12.2 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF4637 PF15470.6 ETO16829.1 - 0.19 11.4 7.2 0.27 11.0 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CDC45 PF02724.14 ETO16829.1 - 0.45 8.7 6.7 0.46 8.7 6.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO16829.1 - 1.9 7.7 4.3 1.8 7.7 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO16829.1 - 9.1 4.9 7.1 9.3 4.9 7.1 1.1 1 0 0 1 1 1 0 Presenilin Ribosomal_L28e PF01778.17 ETO16830.1 - 1.1e-19 71.3 4.7 1.1e-19 71.3 4.7 1.8 1 1 1 2 2 2 1 Ribosomal L28e protein family DUF2015 PF09435.10 ETO16830.1 - 0.033 14.0 0.2 0.064 13.1 0.2 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) DUF3811 PF11656.8 ETO16830.1 - 1.4 9.3 11.8 0.16 12.4 4.6 2.5 2 1 1 3 3 3 0 YjbD family (DUF3811) STAT_int PF02865.17 ETO16831.1 - 0.083 13.4 0.6 0.083 13.4 0.6 2.0 1 1 0 2 2 2 0 STAT protein, protein interaction domain Dala_Dala_lig_N PF01820.21 ETO16831.1 - 0.14 12.7 0.1 0.27 11.7 0.0 1.5 1 1 1 2 2 2 0 D-ala D-ala ligase N-terminus SAE2 PF08573.10 ETO16831.1 - 8.7 7.5 9.8 1.1e+02 3.9 9.8 2.0 1 1 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus RskA PF10099.9 ETO16832.1 - 0.032 14.5 0.1 0.15 12.3 0.0 2.0 3 0 0 3 3 3 0 Anti-sigma-K factor rskA HATPase_c_5 PF14501.6 ETO16832.1 - 0.38 10.7 3.5 22 5.0 0.1 3.3 3 0 0 3 3 3 0 GHKL domain LPP20 PF02169.16 ETO16832.1 - 0.83 10.0 14.5 0.25 11.7 9.9 2.6 2 1 0 2 2 2 0 LPP20 lipoprotein DUF21 PF01595.20 ETO16833.1 - 4.8e-21 75.3 2.6 2e-13 50.4 0.2 2.5 3 0 0 3 3 3 2 Cyclin M transmembrane N-terminal domain Na_H_Exchanger PF00999.21 ETO16834.1 - 8e-29 100.6 14.2 8.6e-29 100.5 14.2 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family TraL PF07178.11 ETO16834.1 - 1.9 9.0 5.2 1.4 9.4 1.5 2.5 1 1 2 3 3 3 0 TraL protein DUF2358 PF10184.9 ETO16835.1 - 0.24 11.7 8.0 0.32 11.3 0.1 3.3 1 1 3 4 4 4 0 Uncharacterized conserved protein (DUF2358) PUB PF09409.10 ETO16836.1 - 0.0095 15.9 2.9 0.074 13.0 2.9 2.3 1 1 0 1 1 1 1 PUB domain Methyltransf_16 PF10294.9 ETO16838.1 - 1.8e-08 34.3 0.4 0.0009 19.0 0.0 2.4 2 0 0 2 2 2 2 Lysine methyltransferase Methyltransf_23 PF13489.6 ETO16838.1 - 0.0049 16.7 0.0 0.0079 16.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO16838.1 - 0.02 15.6 0.3 0.43 11.4 0.3 2.7 1 1 0 1 1 1 0 Methyltransferase domain AdoMet_MTase PF07757.13 ETO16838.1 - 0.077 13.3 0.0 0.19 12.1 0.0 1.6 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase MTS PF05175.14 ETO16838.1 - 0.081 12.5 0.0 6.5 6.3 0.0 2.4 2 0 0 2 2 2 0 Methyltransferase small domain Methyltransf_31 PF13847.6 ETO16838.1 - 0.13 12.0 5.5 2.6 7.8 0.1 3.3 3 1 0 4 4 4 0 Methyltransferase domain NAD_binding_6 PF08030.12 ETO16840.1 - 2.2e-11 44.1 0.0 5.7e-11 42.8 0.0 1.6 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ETO16840.1 - 0.055 14.1 0.1 0.65 10.7 0.0 2.3 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain WD40 PF00400.32 ETO16842.1 - 2.2e-59 196.0 19.4 1.7e-09 38.1 0.1 8.4 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16842.1 - 1.6e-20 73.2 5.9 0.0014 18.9 0.1 7.5 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16842.1 - 2.8e-13 49.5 8.8 0.011 14.7 0.6 6.8 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16842.1 - 1.2e-08 35.0 2.5 0.002 18.0 0.1 3.7 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO16842.1 - 0.00031 20.6 0.3 4.6 7.3 0.0 3.7 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO16842.1 - 0.0036 15.9 0.1 1.4 7.3 0.0 2.9 2 1 1 3 3 3 2 Cytochrome D1 heme domain Kelch_5 PF13854.6 ETO16842.1 - 0.13 12.3 2.5 8.9 6.4 0.6 3.6 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO16842.1 - 2.1 8.5 5.9 3.7 7.7 0.2 4.1 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO16843.1 - 5.6e-61 201.1 16.0 3e-10 40.5 0.5 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16843.1 - 4.2e-21 75.0 3.0 6.8e-06 26.3 0.1 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16843.1 - 5.3e-13 48.6 2.1 0.084 11.8 0.0 5.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO16843.1 - 6.4e-12 45.8 1.2 6.6e-05 22.9 0.0 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO16843.1 - 4.9e-11 42.0 8.9 0.11 11.1 0.0 5.8 2 2 4 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16843.1 - 9.1e-07 28.5 2.5 0.0026 17.2 0.4 3.3 1 1 1 3 3 3 2 WD40-like domain SBD PF17882.1 ETO16843.1 - 0.0057 16.5 0.2 2.6 7.9 0.0 3.9 1 1 4 5 5 5 1 OAA-family lectin sugar binding domain Cytochrom_D1 PF02239.16 ETO16843.1 - 0.012 14.2 4.0 1.9 6.9 0.3 3.2 2 2 1 3 3 3 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO16843.1 - 0.15 12.1 1.6 82 3.3 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO16843.1 - 0.15 11.7 2.6 6 6.6 0.1 3.9 4 0 0 4 4 4 0 HepA-related protein (HARP) Kelch_4 PF13418.6 ETO16844.1 - 0.0053 16.7 0.2 4.2 7.5 0.0 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO16844.1 - 0.012 15.9 0.1 0.28 11.5 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO16844.1 - 0.014 15.3 0.3 0.97 9.5 0.2 2.4 1 1 1 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO16844.1 - 0.044 13.4 0.2 2.7 7.7 0.2 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO16845.1 - 8.9e-06 25.6 0.1 0.0026 17.7 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO16845.1 - 0.00055 19.8 0.6 0.25 11.4 0.1 2.7 2 1 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO16845.1 - 0.015 15.6 0.1 4 7.9 0.2 2.4 2 0 0 2 2 2 0 Kelch motif DUF4408 PF14364.6 ETO16845.1 - 0.21 11.4 1.3 0.44 10.3 1.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4408) CNOT1_CAF1_bind PF16415.5 ETO16847.1 - 1.1e-57 195.1 4.7 1.3e-57 194.8 4.7 1.0 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Vfa1 PF08432.10 ETO16847.1 - 2.2 8.6 7.2 2.9 8.2 7.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mito_carr PF00153.27 ETO16848.1 - 4.5e-18 65.0 0.9 2e-08 34.0 0.2 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein AMP-binding PF00501.28 ETO16849.1 - 7.8e-29 100.5 0.0 8.5e-29 100.4 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Oxidored_nitro PF00148.19 ETO16849.1 - 0.095 11.4 0.0 0.24 10.1 0.0 1.4 1 1 0 1 1 1 0 Nitrogenase component 1 type Oxidoreductase DHHC PF01529.20 ETO16854.1 - 5.5e-35 120.4 13.8 5.5e-35 120.4 13.8 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Laminin_II PF06009.12 ETO16856.1 - 0.02 14.9 2.2 0.023 14.7 2.2 1.1 1 0 0 1 1 1 0 Laminin Domain II RPN6_N PF18055.1 ETO16856.1 - 0.022 15.1 0.3 0.024 15.0 0.3 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN6 N-terminal domain WXG100 PF06013.12 ETO16856.1 - 0.1 12.9 1.0 3.5 7.9 0.3 2.1 2 0 0 2 2 2 0 Proteins of 100 residues with WXG KxDL PF10241.9 ETO16856.1 - 0.21 11.9 3.7 3.3 8.1 3.7 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein HBS1_N PF08938.10 ETO16857.1 - 0.035 14.4 2.5 0.85 10.0 2.8 2.1 2 0 0 2 2 2 0 HBS1 N-terminus Muted PF14942.6 ETO16857.1 - 0.84 10.0 8.4 1.1 9.6 6.8 1.8 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein Spore_SspJ PF09575.10 ETO16857.1 - 1.4 9.3 5.7 5.2 7.5 0.3 3.2 3 0 0 3 3 3 0 Small spore protein J (Spore_SspJ) WD40 PF00400.32 ETO16858.1 - 7.1e-06 26.7 1.9 0.076 13.9 0.2 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF444 PF04285.12 ETO16858.1 - 0.041 12.9 0.1 0.063 12.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF444) Tubulin_C PF03953.17 ETO16859.1 - 1.5e-31 109.2 0.0 2.4e-31 108.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Med1 PF10744.9 ETO16860.1 - 0.04 12.9 1.1 0.044 12.8 1.1 1.0 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 PWI PF01480.17 ETO16861.1 - 0.023 15.0 0.0 0.038 14.3 0.0 1.4 1 0 0 1 1 1 0 PWI domain UCH PF00443.29 ETO16862.1 - 1e-16 61.2 0.0 2.1e-15 56.9 0.0 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO16862.1 - 0.0046 16.6 0.0 0.0048 16.5 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Mucin PF01456.17 ETO16863.1 - 1.2 9.2 24.8 2.4 8.1 24.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Fez1 PF06818.15 ETO16864.1 - 0.011 16.2 7.9 0.23 11.9 2.4 2.4 2 0 0 2 2 2 0 Fez1 BRE1 PF08647.11 ETO16864.1 - 0.013 15.5 3.9 0.013 15.5 3.9 3.4 3 1 0 3 3 3 0 BRE1 E3 ubiquitin ligase DUF2681 PF10883.8 ETO16864.1 - 0.074 13.5 3.0 0.42 11.0 0.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) DUF2457 PF10446.9 ETO16865.1 - 0.07 12.3 22.3 0.07 12.3 22.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 ETO16865.1 - 0.076 12.3 20.7 0.081 12.2 20.7 1.1 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO16865.1 - 0.19 9.9 18.5 0.2 9.8 18.5 1.0 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 ETO16865.1 - 0.2 11.4 22.1 0.22 11.3 22.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2076 PF09849.9 ETO16865.1 - 0.92 9.5 15.1 0.89 9.5 15.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DNA_pol_phi PF04931.13 ETO16865.1 - 1.2 7.2 22.5 1.1 7.2 22.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi PPP4R2 PF09184.11 ETO16865.1 - 1.5 8.3 19.3 1.6 8.3 19.3 1.1 1 0 0 1 1 1 0 PPP4R2 Cellulose_synt PF03552.14 ETO16865.1 - 2.6 6.4 8.1 2.6 6.4 8.1 1.0 1 0 0 1 1 1 0 Cellulose synthase FAM60A PF15396.6 ETO16865.1 - 3.7 7.5 11.6 4.2 7.3 11.6 1.0 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 ETO16865.1 - 7.2 4.8 16.1 6.8 4.8 16.1 1.0 1 0 0 1 1 1 0 CDC45-like protein UPF0560 PF10577.9 ETO16865.1 - 8.2 4.8 12.6 8.9 4.7 12.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PA26 PF04636.13 ETO16867.1 - 0.0019 17.2 1.6 0.0021 17.1 1.6 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Sod_Ni PF09055.11 ETO16867.1 - 0.098 13.2 1.4 0.17 12.5 1.4 1.4 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase GET2 PF08690.10 ETO16867.1 - 5.2 6.6 11.1 6.7 6.3 11.1 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 POTRA_2 PF08479.11 ETO16869.1 - 4.7e-10 39.1 0.4 1.1e-09 37.9 0.1 1.9 2 0 0 2 2 2 1 POTRA domain, ShlB-type ShlB PF03865.13 ETO16869.1 - 1.4e-06 28.0 1.5 0.005 16.3 0.5 2.1 2 0 0 2 2 2 2 Haemolysin secretion/activation protein ShlB/FhaC/HecB POTRA PF07244.15 ETO16869.1 - 0.00022 21.7 0.9 1.7 9.3 0.0 3.1 3 0 0 3 3 3 2 Surface antigen variable number repeat RhoGAP PF00620.27 ETO16870.1 - 0.0051 16.6 0.0 0.021 14.6 0.0 1.9 2 0 0 2 2 2 1 RhoGAP domain WD40 PF00400.32 ETO16871.1 - 4.3e-06 27.4 0.7 0.046 14.6 0.3 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16871.1 - 0.012 15.9 0.0 0.014 15.6 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain GFO_IDH_MocA PF01408.22 ETO16872.1 - 1 10.2 3.3 1.5 9.6 0.3 2.4 2 0 0 2 2 2 0 Oxidoreductase family, NAD-binding Rossmann fold DevR PF01905.16 ETO16874.1 - 0.041 12.9 0.4 0.053 12.6 0.4 1.1 1 0 0 1 1 1 0 CRISPR-associated negative auto-regulator DevR/Csa2 DUF3558 PF12079.8 ETO16874.1 - 0.05 13.6 0.6 0.34 10.9 0.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3558) Nrf1_DNA-bind PF10491.9 ETO16874.1 - 0.13 12.0 1.3 0.24 11.0 1.3 1.4 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 PBP1_TM PF14812.6 ETO16874.1 - 0.24 11.8 4.3 0.34 11.3 3.6 1.5 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF155 PF02582.14 ETO16875.1 - 7.5e-10 39.2 0.7 0.00044 20.4 0.1 2.1 2 0 0 2 2 2 2 Uncharacterised ACR, YagE family COG1723 SAM_2 PF07647.17 ETO16875.1 - 9.5e-09 35.2 0.1 1.8e-08 34.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO16875.1 - 3e-07 30.8 1.4 6.1e-07 29.8 1.4 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF2255 PF10012.9 ETO16875.1 - 0.18 12.0 0.6 0.44 10.7 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) DUF2070 PF09843.9 ETO16875.1 - 1.7 6.9 7.4 2.2 6.4 7.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) adh_short_C2 PF13561.6 ETO16876.1 - 1.1e-56 192.0 0.0 1.8e-56 191.3 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO16876.1 - 5.2e-44 150.0 0.1 1.1e-43 149.0 0.1 1.4 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO16876.1 - 5.5e-07 29.7 0.0 2.5e-06 27.6 0.0 2.1 2 1 0 2 2 2 1 KR domain Methyltransf_25 PF13649.6 ETO16876.1 - 1.3e-05 25.8 0.0 0.00045 20.9 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Epimerase PF01370.21 ETO16876.1 - 0.0012 18.4 0.1 0.0033 16.9 0.1 1.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family Methyltransf_12 PF08242.12 ETO16876.1 - 0.0055 17.4 0.1 0.022 15.5 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain DUF276 PF03434.13 ETO16876.1 - 0.015 14.5 0.5 0.034 13.3 0.4 1.6 2 0 0 2 2 2 0 DUF276 Methyltransf_11 PF08241.12 ETO16876.1 - 0.018 15.7 0.0 0.074 13.7 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase domain AAA_31 PF13614.6 ETO16876.1 - 0.02 14.8 0.0 0.033 14.1 0.0 1.4 1 0 0 1 1 1 0 AAA domain Polysacc_synt_2 PF02719.15 ETO16876.1 - 0.038 13.1 0.3 0.049 12.7 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PH_BEACH PF14844.6 ETO16877.1 - 7.2 6.8 8.7 38 4.4 2.4 3.6 4 0 0 4 4 4 0 PH domain associated with Beige/BEACH Secretin_N_2 PF07655.13 ETO16879.1 - 0.066 13.8 6.8 0.12 12.9 6.8 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Vps54_N PF10475.9 ETO16880.1 - 1.6e-12 47.3 4.4 2.4e-12 46.8 4.4 1.1 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex MMS19_N PF14500.6 ETO16880.1 - 0.011 15.4 0.2 0.56 9.7 0.0 2.2 2 0 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II DUF2514 PF10721.9 ETO16881.1 - 0.13 12.2 0.4 0.2 11.7 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) Cytochrom_C1 PF02167.15 ETO16882.1 - 2.1e-55 187.8 3.8 4e-37 128.1 0.0 3.0 2 1 1 3 3 3 3 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ETO16882.1 - 0.0019 18.5 0.0 0.0069 16.7 0.0 2.0 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ETO16882.1 - 0.05 14.7 0.0 0.15 13.2 0.0 1.8 1 0 0 1 1 1 0 Cytochrome c TraG_N PF07916.11 ETO16883.1 - 0.0088 14.9 4.1 0.01 14.8 4.1 1.0 1 0 0 1 1 1 1 TraG-like protein, N-terminal region RIC3 PF15361.6 ETO16884.1 - 0.12 12.7 2.9 0.18 12.2 2.9 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 zf-C3HC4 PF00097.25 ETO16887.1 - 0.00074 19.3 1.2 0.0021 17.9 1.2 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ETO16887.1 - 0.019 15.1 5.0 0.032 14.4 5.0 1.6 1 1 0 1 1 1 0 FYVE zinc finger zf-C3HC4_3 PF13920.6 ETO16887.1 - 0.031 14.1 2.9 0.031 14.1 2.9 1.8 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO16887.1 - 0.062 13.7 2.4 0.062 13.7 2.4 1.9 2 0 0 2 2 2 0 Ring finger domain DUF4834 PF16118.5 ETO16887.1 - 0.12 13.3 5.8 6.8 7.7 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4666 PF15697.5 ETO16887.1 - 0.9 10.2 4.9 5.4 7.7 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4666) zf-C3HC4_2 PF13923.6 ETO16887.1 - 1.7 8.6 7.7 0.22 11.4 3.4 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CCDC106 PF15794.5 ETO16887.1 - 1.7 8.3 12.3 0.097 12.4 0.9 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Menin PF05053.13 ETO16887.1 - 4.6 5.5 15.7 0.062 11.7 5.8 1.9 2 0 0 2 2 2 0 Menin zf-RING_5 PF14634.6 ETO16887.1 - 5.5 7.0 9.7 16 5.6 9.7 1.8 1 1 0 1 1 1 0 zinc-RING finger domain Presenilin PF01080.17 ETO16887.1 - 8.3 5.0 8.5 18 4.0 8.5 1.5 1 1 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETO16888.1 - 0.017 16.1 2.8 0.022 15.7 2.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO16888.1 - 1.7 7.3 4.9 1.8 7.3 4.9 1.0 1 0 0 1 1 1 0 Presenilin DUF2076 PF09849.9 ETO16888.1 - 7.4 6.5 14.6 8.6 6.3 14.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) HAD_2 PF13419.6 ETO16890.1 - 1.7e-25 90.1 0.1 4.5e-25 88.8 0.0 1.7 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETO16890.1 - 9e-09 35.9 0.0 1.9e-08 34.9 0.0 1.5 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO16890.1 - 0.00025 21.5 0.0 0.00045 20.7 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Ribosomal_L12_N PF16320.5 ETO16890.1 - 0.053 13.2 0.0 0.11 12.2 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain E1-E2_ATPase PF00122.20 ETO16891.1 - 1.7e-43 148.3 1.8 1.7e-43 148.3 1.8 2.5 3 0 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ETO16891.1 - 5.4e-25 88.9 0.0 1.1e-24 87.9 0.0 1.6 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HMA PF00403.26 ETO16891.1 - 4.6e-08 33.4 0.3 1.6e-07 31.7 0.0 2.1 2 0 0 2 2 2 1 Heavy-metal-associated domain ATPase-cat_bd PF12156.8 ETO16891.1 - 7.8e-06 26.5 3.6 2.1e-05 25.2 3.6 1.7 1 0 0 1 1 1 1 Putative metal-binding domain of cation transport ATPase Hydrolase_3 PF08282.12 ETO16891.1 - 1 9.0 9.3 0.36 10.5 2.6 2.9 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase Trigger_C PF05698.14 ETO16892.1 - 1.9e-29 102.8 14.3 5.2e-28 98.1 6.5 3.1 3 0 0 3 3 3 2 Bacterial trigger factor protein (TF) C-terminus Trigger_N PF05697.13 ETO16892.1 - 1.9e-29 102.8 3.8 1.9e-29 102.8 3.8 2.4 2 1 0 2 2 2 1 Bacterial trigger factor protein (TF) TraC PF07820.12 ETO16892.1 - 0.79 10.1 3.9 5.3 7.4 0.1 3.5 4 0 0 4 4 4 0 TraC-like protein Cytochrom_B562 PF07361.11 ETO16892.1 - 3 8.6 8.2 0.72 10.5 1.7 2.9 2 1 0 2 2 2 0 Cytochrome b562 DIE2_ALG10 PF04922.12 ETO16893.1 - 6.8e-38 131.0 0.5 1.1e-37 130.3 0.5 1.3 1 1 0 1 1 1 1 DIE2/ALG10 family PH PF00169.29 ETO16896.1 - 0.0082 16.6 2.4 0.06 13.9 0.0 2.7 3 0 0 3 3 3 1 PH domain DUF1192 PF06698.11 ETO16896.1 - 0.019 15.0 0.1 0.13 12.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PH_12 PF16457.5 ETO16896.1 - 0.054 14.0 0.1 0.054 14.0 0.1 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain DUF2644 PF10841.8 ETO16897.1 - 0.15 12.3 0.3 0.15 12.3 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2644) WD40 PF00400.32 ETO16898.1 - 1.8e-43 145.7 28.2 2.4e-08 34.5 1.4 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16898.1 - 1.2e-12 48.0 2.3 0.071 13.4 0.0 5.3 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16898.1 - 3.4e-06 26.0 14.3 0.015 14.0 0.5 5.5 2 2 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16898.1 - 9.2e-06 25.2 8.2 0.054 12.8 0.3 4.5 2 2 2 5 5 5 2 WD40-like domain DUF2431 PF10354.9 ETO16899.1 - 1.8e-15 57.6 0.8 3.8e-15 56.6 0.3 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) Thioredoxin_7 PF13899.6 ETO16901.1 - 8.5e-11 41.9 0.1 5.4e-10 39.3 0.1 2.1 1 1 1 2 2 2 1 Thioredoxin-like Thioredoxin PF00085.20 ETO16901.1 - 0.0018 18.3 0.1 0.0036 17.3 0.1 1.5 1 0 0 1 1 1 1 Thioredoxin DEP PF00610.21 ETO16905.1 - 2e-37 127.1 2.9 1.9e-19 69.5 0.1 4.0 4 0 0 4 4 4 3 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) O-antigen_lig PF13425.6 ETO16905.1 - 0.6 8.8 11.7 0.055 12.2 2.6 2.1 2 0 0 2 2 2 0 O-antigen ligase like membrane protein NOA36 PF06524.12 ETO16906.1 - 0.0026 17.1 4.8 0.0029 17.0 4.8 1.1 1 0 0 1 1 1 1 NOA36 protein DUF2076 PF09849.9 ETO16906.1 - 0.31 11.0 9.9 0.37 10.8 9.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4834 PF16118.5 ETO16906.1 - 1.3 10.0 6.7 2.4 9.2 6.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO16906.1 - 3.1 6.5 6.2 3.7 6.2 6.2 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 ETO16906.1 - 8.6 5.1 5.7 11 4.7 5.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family P2X_receptor PF00864.19 ETO16907.1 - 1.6e-10 40.6 0.0 2.6e-10 39.9 0.0 1.3 1 0 0 1 1 1 1 ATP P2X receptor SPATA3 PF15662.5 ETO16907.1 - 0.11 13.2 4.1 0.13 12.9 4.1 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family Hydrolase_4 PF12146.8 ETO16908.1 - 2.9e-12 46.4 0.0 1e-05 25.0 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO16908.1 - 3.4e-07 30.2 0.1 0.0034 17.1 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ETO16908.1 - 8.8e-06 25.7 0.0 6.6e-05 22.8 0.0 1.9 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase DLH PF01738.18 ETO16908.1 - 1e-05 25.2 0.0 8.1e-05 22.3 0.0 1.9 1 1 0 1 1 1 1 Dienelactone hydrolase family BAAT_C PF08840.11 ETO16908.1 - 1.1e-05 25.5 0.0 0.15 12.0 0.0 2.7 2 1 1 3 3 3 2 BAAT / Acyl-CoA thioester hydrolase C terminal Abhydrolase_3 PF07859.13 ETO16908.1 - 0.0017 18.2 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold UPF0227 PF05728.12 ETO16908.1 - 0.0018 18.2 0.0 0.0044 17.0 0.0 1.6 1 1 0 1 1 1 1 Uncharacterised protein family (UPF0227) Abhydrolase_6 PF12697.7 ETO16908.1 - 0.0025 18.4 0.0 0.25 11.9 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Peptidase_S9 PF00326.21 ETO16908.1 - 0.0026 17.3 0.0 0.0039 16.7 0.0 1.4 1 1 0 1 1 1 1 Prolyl oligopeptidase family DUF1749 PF08538.10 ETO16908.1 - 0.0062 15.7 0.0 1.8 7.6 0.0 2.1 2 0 0 2 2 2 2 Protein of unknown function (DUF1749) AXE1 PF05448.12 ETO16908.1 - 0.02 13.6 0.0 0.025 13.2 0.0 1.3 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase PF00756.20 ETO16908.1 - 0.023 14.4 0.0 0.032 13.9 0.0 1.4 1 1 0 1 1 1 0 Putative esterase FSH1 PF03959.13 ETO16908.1 - 0.036 13.7 0.0 0.11 12.2 0.0 1.7 1 1 0 1 1 1 0 Serine hydrolase (FSH1) DUF829 PF05705.14 ETO16908.1 - 0.095 12.6 0.0 0.16 11.8 0.0 1.5 1 1 1 2 2 2 0 Eukaryotic protein of unknown function (DUF829) DUF2974 PF11187.8 ETO16908.1 - 0.1 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) Abhydrolase_9 PF10081.9 ETO16908.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family Esterase_phd PF10503.9 ETO16908.1 - 0.13 11.8 0.0 0.17 11.3 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase Abhydrolase_5 PF12695.7 ETO16908.1 - 0.2 11.4 0.0 0.44 10.3 0.0 1.5 2 0 0 2 2 2 0 Alpha/beta hydrolase family EF-hand_6 PF13405.6 ETO16909.1 - 0.0068 16.3 0.0 0.0068 16.3 0.0 3.6 4 0 0 4 4 4 1 EF-hand domain AA_permease PF00324.21 ETO16909.1 - 0.077 11.6 6.5 0.12 10.9 6.5 1.3 1 0 0 1 1 1 0 Amino acid permease Shisa PF13908.6 ETO16909.1 - 0.086 13.1 3.9 0.18 12.0 3.9 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator EphA2_TM PF14575.6 ETO16909.1 - 0.098 13.6 3.4 0.088 13.7 1.0 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain GET2 PF08690.10 ETO16909.1 - 0.38 10.4 4.9 0.48 10.0 0.5 2.0 2 0 0 2 2 2 0 GET complex subunit GET2 EF-hand_7 PF13499.6 ETO16909.1 - 0.49 10.9 6.1 3.2 8.3 4.0 2.9 2 1 1 3 3 3 0 EF-hand domain pair PspB PF06667.12 ETO16909.1 - 1.1 9.4 8.8 1.2 9.2 2.6 2.6 2 0 0 2 2 2 0 Phage shock protein B WSS_VP PF12175.8 ETO16909.1 - 1.2 8.5 12.1 2 7.9 12.1 1.3 1 0 0 1 1 1 0 White spot syndrome virus structural envelope protein VP Sigma_reg_N PF13800.6 ETO16909.1 - 1.5 9.1 15.6 0.48 10.8 12.5 1.7 2 0 0 2 2 2 0 Sigma factor regulator N-terminal Baculo_11_kDa PF06143.11 ETO16909.1 - 2.8 7.6 11.2 7.5 6.2 11.2 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family Tmemb_9 PF05434.11 ETO16909.1 - 4.1 7.3 8.0 9.9 6.0 8.0 1.7 1 0 0 1 1 1 0 TMEM9 DUF4446 PF14584.6 ETO16909.1 - 5 7.1 13.8 0.48 10.4 4.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) Ion_trans PF00520.31 ETO16910.1 - 3.8e-15 55.8 15.2 3.8e-15 55.8 15.2 1.6 2 0 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 ETO16910.1 - 5.7e-10 38.5 13.8 1.4e-09 37.2 13.8 1.6 1 1 0 1 1 1 1 Polycystin cation channel DUF2157 PF09925.9 ETO16910.1 - 0.05 13.4 3.6 0.9 9.3 3.6 2.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) TraP PF07296.11 ETO16910.1 - 0.42 9.8 3.5 0.31 10.2 0.2 2.3 2 0 0 2 2 2 0 TraP protein SAM_1 PF00536.30 ETO16911.1 - 1.6e-20 73.3 0.1 2.1e-20 72.9 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO16911.1 - 1.1e-17 63.9 0.1 1.4e-17 63.5 0.1 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ETO16911.1 - 3.3e-07 30.2 0.0 5.7e-07 29.4 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO16911.1 - 8.9e-05 22.4 0.0 0.00016 21.5 0.0 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_3 PF18016.1 ETO16911.1 - 0.0026 17.5 0.0 0.0042 16.9 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO16911.1 - 0.051 13.8 0.1 0.08 13.2 0.1 1.4 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Ish1 PF10281.9 ETO16911.1 - 0.093 13.1 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Putative stress-responsive nuclear envelope protein Abhydrolase_6 PF12697.7 ETO16912.1 - 5.2e-19 69.7 0.0 7e-19 69.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETO16912.1 - 1.1e-16 61.3 0.4 1.2e-15 57.9 0.4 2.2 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO16912.1 - 1.4e-07 31.1 0.0 4.4e-07 29.4 0.0 1.9 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Ndr PF03096.14 ETO16912.1 - 5.1e-07 28.7 0.1 9.1e-07 27.9 0.1 1.3 1 0 0 1 1 1 1 Ndr family Ser_hydrolase PF06821.13 ETO16912.1 - 4.1e-05 23.5 0.4 0.15 11.9 0.1 2.9 3 0 0 3 3 3 2 Serine hydrolase Glyco_hydro_42 PF02449.15 ETO16912.1 - 0.0045 16.4 0.0 0.0072 15.7 0.0 1.2 1 0 0 1 1 1 1 Beta-galactosidase Abhydrolase_8 PF06259.12 ETO16912.1 - 0.023 14.3 0.0 0.049 13.3 0.0 1.5 1 0 0 1 1 1 0 Alpha/beta hydrolase Esterase PF00756.20 ETO16912.1 - 0.042 13.5 0.0 0.078 12.6 0.0 1.4 1 0 0 1 1 1 0 Putative esterase Peptidase_S9 PF00326.21 ETO16912.1 - 0.12 11.8 0.1 4 6.8 0.0 2.4 1 1 1 2 2 2 0 Prolyl oligopeptidase family NAGPA PF09992.9 ETO16913.1 - 1.3e-22 80.8 0.0 4.6e-21 75.8 0.0 2.5 2 1 0 2 2 2 1 Phosphodiester glycosidase Phage_T7_tail PF03906.14 ETO16913.1 - 0.16 11.6 0.0 0.28 10.8 0.0 1.4 1 0 0 1 1 1 0 Phage T7 tail fibre protein Tubulin_C PF03953.17 ETO16914.1 - 2.3e-20 73.0 0.1 4.8e-20 72.0 0.1 1.5 1 1 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO16914.1 - 1.3e-19 71.2 0.0 2.2e-19 70.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain RRM_1 PF00076.22 ETO16915.1 - 0.0088 15.8 0.0 0.029 14.2 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) VRP3 PF03536.15 ETO16916.1 - 0.039 13.4 0.2 0.09 12.3 0.1 1.4 1 1 0 1 1 1 0 Salmonella virulence-associated 28kDa protein PPP5 PF08321.12 ETO16916.1 - 0.06 13.6 0.6 0.06 13.6 0.6 1.8 2 1 0 2 2 2 0 PPP5 TPR repeat region Peptidase_C2 PF00648.21 ETO16918.1 - 2.3e-29 102.4 0.0 2.7e-29 102.1 0.0 1.0 1 0 0 1 1 1 1 Calpain family cysteine protease Ion_trans PF00520.31 ETO16919.1 - 1.3e-13 50.8 4.4 1.9e-13 50.2 4.4 1.2 1 0 0 1 1 1 1 Ion transport protein GPHH PF16905.5 ETO16919.1 - 0.0013 18.5 0.0 0.0022 17.7 0.0 1.4 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated DUF2063 PF09836.9 ETO16919.1 - 0.063 13.5 0.3 0.16 12.3 0.2 1.6 2 0 0 2 2 2 0 Putative DNA-binding domain Rsm22 PF09243.10 ETO16920.1 - 9.8e-13 48.0 0.0 3.1e-09 36.5 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 DEP PF00610.21 ETO16922.1 - 5.8e-11 42.3 0.1 1.6e-10 40.9 0.1 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) MPS2 PF17060.5 ETO16923.1 - 0.00025 20.4 7.6 0.00029 20.2 7.6 1.1 1 0 0 1 1 1 1 Monopolar spindle protein 2 IFT20 PF14931.6 ETO16923.1 - 0.0098 16.1 10.6 0.0098 16.1 10.6 1.9 1 1 1 2 2 2 1 Intraflagellar transport complex B, subunit 20 Macoilin PF09726.9 ETO16923.1 - 0.013 14.2 13.3 0.014 14.0 13.3 1.0 1 0 0 1 1 1 0 Macoilin family HopA1 PF17914.1 ETO16923.1 - 0.021 14.6 0.5 0.031 14.0 0.5 1.3 1 0 0 1 1 1 0 HopA1 effector protein family Jnk-SapK_ap_N PF09744.9 ETO16923.1 - 0.021 15.1 12.9 0.028 14.7 12.9 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Atg14 PF10186.9 ETO16923.1 - 0.027 13.6 13.4 0.032 13.3 13.4 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2353 PF09789.9 ETO16923.1 - 0.054 12.9 17.2 0.092 12.1 17.2 1.4 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) HAP1_N PF04849.13 ETO16923.1 - 0.083 12.1 17.4 0.11 11.7 17.4 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region TetR_C_24 PF17932.1 ETO16923.1 - 0.12 12.7 0.9 0.31 11.3 0.8 1.7 2 1 0 2 2 1 0 Tetracyclin repressor-like, C-terminal domain PKcGMP_CC PF16808.5 ETO16923.1 - 0.14 12.0 0.6 0.14 12.0 0.6 2.0 2 1 0 2 2 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HMMR_N PF15905.5 ETO16923.1 - 0.19 11.1 15.2 0.24 10.8 15.2 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal NBD_C PF17042.5 ETO16923.1 - 0.21 12.1 4.6 0.29 11.6 4.6 1.2 1 0 0 1 1 1 0 Nucleotide-binding C-terminal domain Cnn_1N PF07989.11 ETO16923.1 - 0.24 11.6 12.8 1.3 9.3 3.2 2.4 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 JAKMIP_CC3 PF16034.5 ETO16923.1 - 0.25 11.3 19.9 1.1 9.1 9.1 2.7 1 1 1 2 2 2 0 JAKMIP CC3 domain HIP1_clath_bdg PF16515.5 ETO16923.1 - 0.26 11.9 21.2 0.94 10.1 14.9 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-F_leu_zip PF10473.9 ETO16923.1 - 0.28 11.2 13.8 0.13 12.3 9.2 2.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cep57_CLD_2 PF14197.6 ETO16923.1 - 0.37 10.9 12.3 8 6.6 9.9 3.1 1 1 2 3 3 3 0 Centrosome localisation domain of PPC89 Tho2 PF11262.8 ETO16923.1 - 0.41 9.8 10.2 0.55 9.4 10.2 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF4400 PF14348.6 ETO16923.1 - 0.43 10.1 1.4 0.6 9.6 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) UPF0184 PF03670.13 ETO16923.1 - 0.43 11.0 13.5 0.089 13.2 5.9 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0184) FAP206 PF12018.8 ETO16923.1 - 0.47 9.9 11.5 0.68 9.4 10.6 1.6 1 1 1 2 2 2 0 Domain of unknown function HALZ PF02183.18 ETO16923.1 - 0.62 10.3 7.9 0.42 10.9 0.7 3.0 2 1 1 3 3 2 0 Homeobox associated leucine zipper SOGA PF11365.8 ETO16923.1 - 0.68 11.1 9.9 0.45 11.7 7.6 1.9 1 1 1 2 2 2 0 Protein SOGA Dynein_attach_N PF15867.5 ETO16923.1 - 1.1 9.3 9.3 1.6 8.8 0.7 3.1 2 1 1 3 3 3 0 Dynein attachment factor N-terminus CENP-H PF05837.12 ETO16923.1 - 1.2 9.6 13.6 0.79 10.2 11.1 2.0 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Fib_alpha PF08702.10 ETO16923.1 - 1.6 8.9 17.0 1.7 8.8 13.1 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family zf-C4H2 PF10146.9 ETO16923.1 - 1.7 8.9 12.2 2.4 8.4 12.2 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein HalX PF08663.10 ETO16923.1 - 2.6 8.5 8.9 1 9.8 0.9 2.3 1 1 1 2 2 2 0 HalX domain V_ATPase_I PF01496.19 ETO16923.1 - 4.1 5.2 12.9 4.7 5.0 12.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ADIP PF11559.8 ETO16923.1 - 4.1 7.5 25.1 0.87 9.7 10.0 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 ETO16923.1 - 4.4 6.8 13.2 5.3 6.5 13.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tropomyosin_1 PF12718.7 ETO16923.1 - 5.2 7.2 18.9 1.1 9.4 12.2 2.2 1 1 1 2 2 2 0 Tropomyosin like TMPIT PF07851.13 ETO16923.1 - 5.5 6.1 12.3 3.2 6.9 10.1 1.5 1 1 1 2 2 2 0 TMPIT-like protein DUF4407 PF14362.6 ETO16923.1 - 5.9 6.2 20.3 6.1 6.1 10.4 1.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Prominin PF05478.11 ETO16923.1 - 6.3 4.6 15.3 0.24 9.3 4.8 1.9 1 1 1 2 2 2 0 Prominin APG6_N PF17675.1 ETO16923.1 - 7.7 7.1 19.5 12 6.4 19.5 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETO16923.1 - 9.3 6.3 10.8 14 5.7 4.6 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) CSTF2_hinge PF14327.6 ETO16924.1 - 2.7e-14 53.3 2.4 2.7e-14 53.3 2.4 2.9 4 0 0 4 4 4 1 Hinge domain of cleavage stimulation factor subunit 2 H_PPase PF03030.16 ETO16925.1 - 4.5e-204 679.8 14.9 5.9e-204 679.4 14.9 1.2 1 0 0 1 1 1 1 Inorganic H+ pyrophosphatase WD40 PF00400.32 ETO16926.1 - 4.2e-61 201.4 20.6 4.6e-10 39.9 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16926.1 - 3.1e-13 49.8 4.6 0.25 11.7 0.0 6.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO16926.1 - 8.7e-11 41.7 2.5 0.0005 19.5 0.2 3.6 2 2 2 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO16926.1 - 1.3e-09 37.5 0.7 0.19 10.6 0.0 6.1 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO16926.1 - 2.6e-08 33.0 6.0 0.31 9.6 0.0 5.6 2 1 4 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO16926.1 - 3.6e-07 30.3 0.3 0.051 13.4 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO16926.1 - 1.7e-05 23.6 1.8 0.011 14.4 0.0 3.1 1 1 1 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO16926.1 - 0.077 11.9 1.2 9.5 5.0 0.0 3.6 2 1 2 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO16926.1 - 0.078 12.9 1.0 30 4.7 0.0 4.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat UN_NPL4 PF11543.8 ETO16926.1 - 0.092 13.2 0.1 4.4 7.8 0.0 3.2 4 0 0 4 4 4 0 Nuclear pore localisation protein NPL4 HALZ PF02183.18 ETO16929.1 - 0.003 17.7 3.6 0.048 13.9 0.3 2.5 2 0 0 2 2 2 2 Homeobox associated leucine zipper BRE1 PF08647.11 ETO16929.1 - 0.037 14.1 8.8 0.052 13.6 8.8 1.1 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase Apolipoprotein PF01442.18 ETO16930.1 - 0.0064 16.4 4.6 0.47 10.3 0.7 2.1 2 0 0 2 2 2 2 Apolipoprotein A1/A4/E domain SlyX PF04102.12 ETO16930.1 - 0.025 15.2 7.8 0.42 11.3 2.5 2.5 2 0 0 2 2 2 0 SlyX TMF_TATA_bd PF12325.8 ETO16930.1 - 0.028 14.7 11.2 0.44 10.8 1.8 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding PKHD_C PF18331.1 ETO16930.1 - 0.043 13.9 0.3 0.13 12.4 0.3 1.8 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain DivIC PF04977.15 ETO16930.1 - 0.054 13.3 0.6 0.054 13.3 0.6 2.6 3 0 0 3 3 2 0 Septum formation initiator DUF2848 PF11010.8 ETO16930.1 - 0.061 12.9 0.5 0.11 12.1 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2848) Trimer_CC PF08954.11 ETO16930.1 - 0.062 12.9 1.3 0.062 12.9 1.3 2.0 2 0 0 2 2 2 0 Trimerisation motif FliJ PF02050.16 ETO16930.1 - 0.077 13.2 9.8 0.63 10.3 1.1 2.4 2 0 0 2 2 2 0 Flagellar FliJ protein DUF4407 PF14362.6 ETO16930.1 - 0.18 11.2 3.5 0.32 10.3 3.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TolA_bind_tri PF16331.5 ETO16930.1 - 0.18 11.9 7.5 0.089 12.9 2.2 2.4 2 0 0 2 2 2 0 TolA binding protein trimerisation Atg14 PF10186.9 ETO16930.1 - 0.24 10.4 8.6 0.36 9.9 8.6 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF948 PF06103.11 ETO16930.1 - 0.26 11.6 2.2 0.42 10.9 0.1 2.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Phage_HK97_TLTM PF06120.11 ETO16930.1 - 0.32 10.2 7.6 0.5 9.5 7.6 1.3 1 0 0 1 1 1 0 Tail length tape measure protein XhlA PF10779.9 ETO16930.1 - 0.32 11.2 5.0 1.1 9.5 1.8 2.7 2 0 0 2 2 2 0 Haemolysin XhlA HIP1_clath_bdg PF16515.5 ETO16930.1 - 0.44 11.2 11.0 3.2 8.4 2.4 2.6 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4200 PF13863.6 ETO16930.1 - 0.45 10.9 13.0 0.14 12.5 0.8 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) Syntaxin-6_N PF09177.11 ETO16930.1 - 0.99 10.0 9.2 22 5.7 9.1 2.4 1 1 0 1 1 1 0 Syntaxin 6, N-terminal ADIP PF11559.8 ETO16930.1 - 1.1 9.3 13.1 0.1 12.7 1.9 2.5 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Fib_alpha PF08702.10 ETO16930.1 - 1.1 9.4 13.0 0.4 10.9 2.4 2.5 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family TPR_MLP1_2 PF07926.12 ETO16930.1 - 1.5 8.9 11.0 0.8 9.8 1.7 2.9 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4446 PF14584.6 ETO16930.1 - 2.4 8.2 10.2 0.29 11.1 1.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4094 PF13334.6 ETO16930.1 - 2.8 8.4 10.3 2.1 8.8 1.0 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4094) DUF16 PF01519.16 ETO16930.1 - 8.7 6.9 12.5 0.36 11.3 1.4 2.5 1 1 0 2 2 2 0 Protein of unknown function DUF16 G-alpha PF00503.20 ETO16931.1 - 2.4e-46 158.5 13.6 3e-46 158.2 13.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO16931.1 - 3.9e-09 36.2 0.5 7.9e-09 35.2 0.5 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family Sema PF01403.19 ETO16931.1 - 3.2e-05 22.9 1.2 4.5e-05 22.5 1.2 1.3 1 0 0 1 1 1 1 Sema domain Lipase_GDSL PF00657.22 ETO16931.1 - 0.0034 17.4 0.1 0.098 12.6 0.0 2.1 1 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase SET_assoc PF11767.8 ETO16932.1 - 0.011 15.4 0.0 0.024 14.3 0.0 1.6 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated DUF416 PF04222.12 ETO16932.1 - 0.09 12.2 1.1 0.19 11.1 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF416) Nitr_red_alph_N PF14710.6 ETO16932.1 - 0.17 12.3 0.1 0.45 11.0 0.1 1.7 1 0 0 1 1 1 0 Respiratory nitrate reductase alpha N-terminal Sec7_N PF12783.7 ETO16933.1 - 5.4e-07 29.6 0.0 1.6e-06 28.1 0.0 1.9 1 1 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal zf-HIT PF04438.16 ETO16933.1 - 5.7e-05 22.9 1.5 0.0001 22.1 1.5 1.4 1 0 0 1 1 1 1 HIT zinc finger Presenilin PF01080.17 ETO16933.1 - 0.21 10.3 1.9 0.27 9.9 1.9 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO16933.1 - 3.3 6.8 7.1 4.5 6.4 7.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ETO16933.1 - 5.2 6.8 12.5 7.3 6.3 12.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1676 PF07898.13 ETO16935.1 - 0.17 11.9 2.5 0.2 11.7 2.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) HGTP_anticodon2 PF12745.7 ETO16935.1 - 0.19 11.2 8.1 0.22 11.0 8.1 1.1 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs GWT1 PF06423.12 ETO16935.1 - 0.2 11.8 0.0 0.23 11.6 0.0 1.1 1 0 0 1 1 1 0 GWT1 Allexi_40kDa PF05549.11 ETO16935.1 - 1.2 8.6 3.8 1.4 8.4 3.8 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein CDC45 PF02724.14 ETO16935.1 - 1.6 7.0 6.2 1.8 6.8 6.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO16935.1 - 2.5 8.4 11.8 3.2 8.1 11.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Ferlin_C PF16165.5 ETO16935.1 - 6 6.8 8.6 7.6 6.5 8.6 1.1 1 0 0 1 1 1 0 Ferlin C-terminus Sec62 PF03839.16 ETO16935.1 - 7.2 6.0 8.9 9 5.7 8.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO16935.1 - 9.3 4.9 5.4 10 4.8 5.4 1.1 1 0 0 1 1 1 0 Presenilin vATP-synt_AC39 PF01992.16 ETO16936.1 - 9.2e-22 78.0 0.0 1e-21 77.9 0.0 1.0 1 0 0 1 1 1 1 ATP synthase (C/AC39) subunit IQCJ-SCHIP1 PF15157.6 ETO16937.1 - 0.0012 18.7 8.2 0.0025 17.7 8.2 1.5 1 0 0 1 1 1 1 Fusion protein IQCJ-SCHIP1 with IQ-like motif Pheromone PF08015.11 ETO16937.1 - 0.76 10.9 11.1 0.26 12.3 7.7 2.1 2 0 0 2 2 2 0 Fungal mating-type pheromone CENP-I PF07778.11 ETO16937.1 - 0.76 8.4 5.3 0.068 11.9 0.7 1.5 2 0 0 2 2 2 0 Mis6 Macoilin PF09726.9 ETO16937.1 - 1.1 7.7 10.7 1.4 7.4 10.7 1.3 1 1 0 1 1 1 0 Macoilin family Rrn6 PF10214.9 ETO16937.1 - 1.3 7.4 16.2 0.18 10.3 12.4 1.5 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor DUF1664 PF07889.12 ETO16938.1 - 0.007 16.4 0.9 0.012 15.7 0.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Rsa3 PF14615.6 ETO16938.1 - 0.019 14.5 1.0 0.041 13.5 0.9 1.6 1 1 1 2 2 2 0 Ribosome-assembly protein 3 GrpE PF01025.19 ETO16938.1 - 0.038 13.7 2.6 0.076 12.7 2.6 1.5 1 0 0 1 1 1 0 GrpE Vps5 PF09325.10 ETO16938.1 - 0.043 13.4 1.8 0.069 12.7 1.8 1.3 1 0 0 1 1 1 0 Vps5 C terminal like bact-PGI_C PF10432.9 ETO16938.1 - 0.057 13.5 0.0 0.067 13.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial phospho-glucose isomerase C-terminal SIS domain GldM_N PF12081.8 ETO16938.1 - 0.087 12.9 0.6 0.087 12.9 0.6 1.6 2 0 0 2 2 2 0 GldM N-terminal domain LPP PF04728.13 ETO16938.1 - 0.097 13.1 1.9 0.26 11.7 1.9 1.8 1 1 0 1 1 1 0 Lipoprotein leucine-zipper DUF4407 PF14362.6 ETO16938.1 - 0.23 10.8 1.5 0.25 10.7 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YojJ PF10372.9 ETO16938.1 - 0.32 11.1 2.6 0.62 10.2 1.2 2.1 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus IMD PF08397.11 ETO16938.1 - 0.32 10.4 2.7 0.49 9.7 2.7 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain DUF4659 PF15558.6 ETO16938.1 - 0.53 9.1 6.6 2.4 7.0 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4659) YtxH PF12732.7 ETO16938.1 - 1.4 9.5 4.0 1.3 9.6 0.8 2.2 2 0 0 2 2 2 0 YtxH-like protein Phage_GP20 PF06810.11 ETO16938.1 - 2.8 7.7 10.7 0.49 10.2 4.0 2.1 2 0 0 2 2 2 0 Phage minor structural protein GP20 Ribosomal_L24e PF01246.20 ETO16939.1 - 0.08 13.2 0.1 5.5 7.3 0.0 3.1 3 1 1 4 4 4 0 Ribosomal protein L24e YecM PF06185.12 ETO16940.1 - 0.022 14.4 0.5 0.025 14.3 0.5 1.1 1 0 0 1 1 1 0 YecM protein Atg8 PF02991.16 ETO16940.1 - 0.065 13.4 0.2 0.68 10.2 0.1 1.9 1 1 1 2 2 2 0 Autophagy protein Atg8 ubiquitin like Peptidase_C97 PF05903.14 ETO16941.1 - 0.014 15.2 0.1 0.026 14.3 0.1 1.4 1 0 0 1 1 1 0 PPPDE putative peptidase domain LRAT PF04970.13 ETO16941.1 - 0.022 15.0 0.0 0.11 12.8 0.0 2.1 2 0 0 2 2 2 0 Lecithin retinol acyltransferase MFS_1 PF07690.16 ETO16942.1 - 1.6e-09 37.2 41.1 1.7e-06 27.2 12.7 1.9 1 1 1 2 2 2 2 Major Facilitator Superfamily DUF2721 PF11026.8 ETO16942.1 - 0.029 14.3 0.1 0.029 14.3 0.1 3.1 3 1 1 4 4 4 0 Protein of unknown function (DUF2721) DUF2070 PF09843.9 ETO16942.1 - 0.91 7.7 17.1 1.2 7.3 17.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Exo_endo_phos PF03372.23 ETO16943.1 - 0.016 14.7 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Cation_efflux PF01545.21 ETO16943.1 - 0.12 12.1 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Cation efflux family Atrophin-1 PF03154.15 ETO16944.1 - 0.025 12.9 3.0 0.035 12.4 3.0 1.1 1 0 0 1 1 1 0 Atrophin-1 family Secretin_N_2 PF07655.13 ETO16944.1 - 1.6 9.3 19.9 3.2 8.4 7.4 3.3 3 0 0 3 3 3 0 Secretin N-terminal domain CBS PF00571.28 ETO16947.1 - 7.6e-06 26.3 0.0 7.9e-05 23.0 0.0 2.2 1 1 1 2 2 2 1 CBS domain Astro_capsid_p PF12226.8 ETO16948.1 - 0.14 11.3 4.4 0.16 11.1 4.4 1.0 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 ETO16948.1 - 0.58 9.4 4.0 0.55 9.5 4.0 1.1 1 0 0 1 1 1 0 NOA36 protein DUF4131 PF13567.6 ETO16949.1 - 0.32 10.6 9.2 0.48 10.1 1.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Mito_carr PF00153.27 ETO16951.1 - 5.4e-38 128.8 5.3 6.4e-16 58.1 0.1 3.9 2 2 1 3 3 3 3 Mitochondrial carrier protein Tim17 PF02466.19 ETO16951.1 - 0.19 12.1 1.5 2 8.8 0.2 2.3 1 1 1 2 2 2 0 Tim17/Tim22/Tim23/Pmp24 family G-alpha PF00503.20 ETO16952.1 - 2e-30 106.2 11.2 2e-30 106.2 11.2 2.8 3 0 0 3 3 3 1 G-protein alpha subunit RabGAP-TBC PF00566.18 ETO16954.1 - 1.2e-24 87.2 6.1 3.6e-24 85.6 6.1 1.7 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ank_2 PF12796.7 ETO16955.1 - 1.6e-13 51.0 0.0 4.5e-13 49.6 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO16955.1 - 1.2e-12 46.8 0.0 1.6e-05 24.9 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ETO16955.1 - 1.6e-12 47.3 0.1 8.3e-05 22.9 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO16955.1 - 7.6e-11 42.0 0.0 5.3e-06 26.6 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO16955.1 - 4.8e-10 39.8 0.0 1.4e-09 38.3 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO16956.1 - 2.4e-06 27.8 0.1 0.034 14.6 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO16956.1 - 3.4e-05 24.0 0.1 0.11 12.9 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO16956.1 - 3.5e-05 24.3 0.0 0.077 13.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO16956.1 - 5.6e-05 23.2 0.0 0.088 13.4 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETO16956.1 - 0.003 18.1 0.0 3.9 8.2 0.0 2.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) GvpL_GvpF PF06386.11 ETO16956.1 - 0.39 10.6 4.4 0.52 10.2 4.4 1.1 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF PT PF04886.12 ETO16957.1 - 7.2e-15 54.2 153.1 0.0019 17.7 23.4 7.8 3 2 4 7 7 7 6 PT repeat VWA PF00092.28 ETO16957.1 - 1.2e-07 32.1 0.0 0.0034 17.6 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 ETO16957.1 - 2.8e-05 24.7 0.0 0.055 14.1 0.0 2.5 2 0 0 2 2 2 2 von Willebrand factor type A domain YL1 PF05764.13 ETO16959.1 - 0.00093 19.4 0.6 0.0016 18.6 0.6 1.4 1 0 0 1 1 1 1 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 ETO16959.1 - 0.0013 18.5 3.5 0.0028 17.4 3.5 1.5 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 ETO16959.1 - 0.18 10.9 13.6 0.33 10.1 13.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ETO16959.1 - 0.62 10.5 7.0 1.7 9.0 7.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Gly_kinase PF02595.15 ETO16961.1 - 2.9e-123 411.5 0.0 3.3e-123 411.3 0.0 1.0 1 0 0 1 1 1 1 Glycerate kinase family ADH_zinc_N PF00107.26 ETO16961.1 - 0.0032 17.4 0.0 2.2 8.2 0.0 2.6 1 1 1 2 2 2 2 Zinc-binding dehydrogenase Smoa_sbd PF17885.1 ETO16961.1 - 0.1 12.7 0.0 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 Styrene monooxygenase A putative substrate binding domain zf-RVT PF13966.6 ETO16962.1 - 1.1e-05 26.0 1.0 1.9e-05 25.3 1.0 1.4 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase DUF4046 PF13255.6 ETO16962.1 - 0.0077 16.8 0.5 0.058 14.0 0.1 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF4046) PSI_integrin PF17205.3 ETO16962.1 - 0.078 12.7 0.8 0.13 12.0 0.8 1.3 1 0 0 1 1 1 0 Integrin plexin domain WD40 PF00400.32 ETO16963.1 - 2.3e-42 142.1 26.7 4.1e-07 30.6 0.6 7.3 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16963.1 - 2.3e-14 53.4 2.5 0.025 14.9 0.0 5.6 5 1 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16963.1 - 7.1e-10 38.1 8.5 0.43 9.2 0.3 6.0 4 2 2 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO16963.1 - 0.0036 16.7 14.6 0.0067 15.8 0.1 5.2 2 1 2 5 5 5 2 WD40-like domain DUF3800 PF12686.7 ETO16963.1 - 5.3 7.7 6.8 0.55 10.9 1.4 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3800) Peptidase_C14 PF00656.22 ETO16964.1 - 5.6e-10 39.6 1.5 1.3e-09 38.4 1.5 1.5 1 1 0 1 1 1 1 Caspase domain RVT_1 PF00078.27 ETO16965.1 - 5.6e-14 52.2 0.1 7.6e-14 51.8 0.1 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) WD40 PF00400.32 ETO16966.1 - 1.6e-122 395.8 57.9 1.3e-08 35.3 0.0 16.4 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16966.1 - 6.3e-32 109.7 15.8 0.0013 19.0 0.2 12.2 2 2 11 13 13 13 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16966.1 - 1.1e-21 77.1 1.9 0.076 12.0 0.0 11.5 2 2 6 11 11 11 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO16966.1 - 2.7e-17 63.0 20.0 6.7e-05 22.4 0.6 7.3 4 2 3 7 7 7 4 WD40-like domain Nup160 PF11715.8 ETO16966.1 - 9.8e-14 50.9 29.0 0.82 8.2 0.1 12.7 3 3 10 13 13 13 9 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO16966.1 - 1.4e-07 31.0 1.9 2.7e-07 30.1 1.9 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO16966.1 - 2.1e-05 24.3 10.7 11 6.1 0.0 8.1 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO16966.1 - 0.00031 20.8 0.1 0.00078 19.6 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO16966.1 - 0.0031 17.6 0.7 0.0083 16.3 0.7 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO16966.1 - 0.054 12.0 9.3 0.2 10.1 0.5 4.3 3 2 2 5 5 5 0 Cytochrome D1 heme domain Top6b_C PF18000.1 ETO16966.1 - 0.078 13.1 2.9 2.9 8.1 0.0 4.6 5 0 0 5 5 5 0 Type 2 DNA topoisomerase 6 subunit B C-terminal domain DUF1938 PF09153.10 ETO16966.1 - 0.13 12.4 1.3 42 4.3 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF1938) DUF3475 PF11961.8 ETO16966.1 - 0.21 11.7 0.3 2.5e+02 1.8 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) DENN PF02141.21 ETO16968.1 - 1.2e-30 106.8 1.3 2e-30 106.1 1.3 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain Ras PF00071.22 ETO16969.1 - 8.3e-07 28.7 0.1 1.7e-06 27.8 0.0 1.5 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO16969.1 - 2.3e-06 27.8 0.0 3.9e-06 27.1 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 ETO16969.1 - 0.095 12.1 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_22 PF13401.6 ETO16969.1 - 0.1 12.8 0.2 0.26 11.5 0.2 1.7 1 1 0 1 1 1 0 AAA domain PduV-EutP PF10662.9 ETO16969.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation FEZ PF07763.13 ETO16970.1 - 0.11 12.2 4.2 0.17 11.6 4.2 1.2 1 0 0 1 1 1 0 FEZ-like protein CD36 PF01130.21 ETO16973.1 - 6.7e-14 51.3 0.5 8e-14 51.0 0.5 1.1 1 0 0 1 1 1 1 CD36 family IBB PF01749.20 ETO16974.1 - 1.7e-08 34.8 3.2 1.7e-08 34.8 3.2 2.1 2 0 0 2 2 2 1 Importin beta binding domain Arm PF00514.23 ETO16974.1 - 0.00095 19.1 0.1 0.14 12.2 0.1 2.9 2 1 0 2 2 2 1 Armadillo/beta-catenin-like repeat Sulfotransfer_4 PF17784.1 ETO16974.1 - 0.027 14.3 0.1 0.046 13.5 0.1 1.4 1 0 0 1 1 1 0 Sulfotransferase domain HEAT PF02985.22 ETO16974.1 - 0.043 14.1 0.0 16 6.1 0.0 3.1 2 0 0 2 2 2 0 HEAT repeat Arm PF00514.23 ETO16975.1 - 5.1e-07 29.5 0.0 0.08 13.0 0.0 3.5 3 1 0 3 3 3 2 Armadillo/beta-catenin-like repeat RICTOR_V PF14668.6 ETO16975.1 - 0.0023 18.1 0.1 0.011 15.9 0.0 2.1 2 0 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, domain 5 HEAT_EZ PF13513.6 ETO16975.1 - 0.008 16.7 0.0 0.031 14.8 0.0 2.1 2 1 1 3 3 3 2 HEAT-like repeat Microtub_bind PF13931.6 ETO16976.1 - 2.5e-07 31.1 1.9 2.5e-07 31.1 1.9 2.6 2 1 0 2 2 2 1 Kinesin-associated microtubule-binding BCDHK_Adom3 PF10436.9 ETO16976.1 - 0.069 13.0 0.9 0.21 11.4 0.9 1.9 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase RuBisCO_small PF00101.20 ETO16976.1 - 0.24 11.4 4.5 0.41 10.7 0.3 2.5 1 1 2 3 3 3 0 Ribulose bisphosphate carboxylase, small chain Med29 PF11568.8 ETO16976.1 - 0.45 10.7 6.7 0.047 13.9 1.4 2.2 2 2 0 2 2 2 0 Mediator complex subunit 29 TipAS PF07739.13 ETO16976.1 - 0.92 10.1 5.2 0.85 10.2 2.2 2.4 2 1 1 3 3 3 0 TipAS antibiotic-recognition domain Importin_rep_6 PF18829.1 ETO16976.1 - 1.5 9.0 6.5 0.9 9.7 1.6 2.7 3 0 0 3 3 3 0 Importin repeat 6 RecG_N PF17190.4 ETO16976.1 - 2.1 9.1 6.3 2 9.2 0.7 3.0 2 1 1 3 3 3 0 RecG N-terminal helical domain Kinesin PF00225.23 ETO16977.1 - 6.1e-88 294.9 1.5 1.3e-87 293.8 1.5 1.6 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO16977.1 - 2.4e-23 82.7 0.4 1.2e-22 80.5 0.0 2.5 2 0 0 2 2 2 1 Microtubule binding Fanconi_A PF03511.14 ETO16977.1 - 0.071 13.0 0.4 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Fanconi anaemia group A protein Intein_splicing PF14890.6 ETO16977.1 - 3.6 7.5 5.8 5.9 6.9 0.7 3.2 1 1 2 3 3 3 0 Intein splicing domain BCDHK_Adom3 PF10436.9 ETO16978.1 - 9.4e-26 90.6 0.0 1.1e-13 51.3 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ETO16978.1 - 5e-10 39.9 0.0 8.6e-10 39.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO16978.1 - 8.1e-05 22.5 0.0 0.00018 21.4 0.0 1.5 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Apt1 PF10351.9 ETO16979.1 - 0.0028 16.6 14.8 0.0029 16.5 14.8 1.1 1 0 0 1 1 1 1 Golgi-body localisation protein domain Presenilin PF01080.17 ETO16979.1 - 0.012 14.4 17.2 0.014 14.1 17.2 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO16979.1 - 0.017 14.1 16.9 0.02 14.0 16.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO16979.1 - 0.018 13.4 19.0 0.019 13.3 19.0 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 ETO16979.1 - 0.03 13.2 12.3 0.031 13.1 12.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 ETO16979.1 - 0.036 12.9 19.6 0.042 12.6 19.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Macoilin PF09726.9 ETO16979.1 - 0.057 12.0 16.0 0.058 12.0 16.0 1.0 1 0 0 1 1 1 0 Macoilin family SEEEED PF14797.6 ETO16979.1 - 0.23 11.6 34.8 0.32 11.1 34.8 1.2 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex YL1 PF05764.13 ETO16979.1 - 0.23 11.6 29.9 0.3 11.2 29.9 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Paramyxo_ncap PF00973.19 ETO16979.1 - 0.24 10.3 13.4 0.27 10.1 13.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Zip PF02535.22 ETO16979.1 - 0.32 10.2 10.3 0.44 9.7 10.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FancD2 PF14631.6 ETO16979.1 - 0.38 8.1 14.0 0.42 8.0 14.0 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease NARP1 PF12569.8 ETO16979.1 - 0.42 9.5 20.6 0.51 9.2 20.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 GAGA_bind PF06217.12 ETO16979.1 - 0.63 10.3 19.7 0.9 9.8 19.7 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family SAPS PF04499.15 ETO16979.1 - 0.64 8.7 14.4 0.75 8.5 14.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RR_TM4-6 PF06459.12 ETO16979.1 - 0.69 9.7 21.9 0.91 9.3 21.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF2828 PF11443.8 ETO16979.1 - 0.76 7.8 15.1 0.87 7.6 15.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF3807 PF12720.7 ETO16979.1 - 0.89 9.8 27.1 1.4 9.2 27.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Membralin PF09746.9 ETO16979.1 - 0.9 8.5 10.3 1.1 8.3 10.3 1.1 1 0 0 1 1 1 0 Tumour-associated protein Ndc1_Nup PF09531.10 ETO16979.1 - 1.1 7.9 9.4 1.1 7.8 9.4 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MCM_bind PF09739.9 ETO16979.1 - 1.3 7.4 21.1 1.5 7.2 21.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Rrn6 PF10214.9 ETO16979.1 - 1.6 7.2 17.3 1.9 6.9 17.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Peptidase_S64 PF08192.11 ETO16979.1 - 2 6.8 17.6 2.2 6.7 17.6 1.0 1 0 0 1 1 1 0 Peptidase family S64 AAA_11 PF13086.6 ETO16979.1 - 2.5 7.8 17.2 3.4 7.4 17.2 1.2 1 0 0 1 1 1 0 AAA domain GREB1 PF15782.5 ETO16979.1 - 2.8 5.0 13.9 3.1 4.8 13.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 ETO16979.1 - 2.8 7.9 12.1 3.9 7.5 12.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PA26 PF04636.13 ETO16979.1 - 4.1 6.2 12.3 4.7 6.0 12.3 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Band_3_cyto PF07565.13 ETO16979.1 - 4.9 6.9 11.1 6.4 6.5 11.1 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Dsh_C PF12316.8 ETO16979.1 - 6.2 7.2 15.0 7.8 6.8 15.0 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Menin PF05053.13 ETO16979.1 - 6.8 4.9 13.8 8.1 4.7 13.8 1.2 1 0 0 1 1 1 0 Menin B56 PF01603.20 ETO16981.1 - 0.075 12.0 0.3 0.11 11.5 0.0 1.4 2 0 0 2 2 2 0 Protein phosphatase 2A regulatory B subunit (B56 family) RabGAP-TBC PF00566.18 ETO16982.1 - 4.3e-07 29.8 1.2 7.2e-07 29.1 0.0 1.8 2 0 0 2 2 2 1 Rab-GTPase-TBC domain CDC45 PF02724.14 ETO16983.1 - 9.1e-05 21.0 2.6 9.1e-05 21.0 2.6 1.1 1 0 0 1 1 1 1 CDC45-like protein Osteopontin PF00865.18 ETO16983.1 - 0.0016 18.0 20.1 0.0023 17.5 20.1 1.2 1 0 0 1 1 1 1 Osteopontin SAPS PF04499.15 ETO16983.1 - 0.0023 16.8 2.0 0.0023 16.8 2.0 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein NPR3 PF03666.13 ETO16983.1 - 0.0093 14.8 0.8 0.0085 14.9 0.8 1.2 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 ETO16983.1 - 0.11 11.3 1.2 0.16 10.8 1.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Secretin_N_2 PF07655.13 ETO16983.1 - 0.17 12.4 14.7 0.4 11.3 14.7 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain Presenilin PF01080.17 ETO16983.1 - 0.4 9.4 2.8 0.47 9.2 2.8 1.1 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 ETO16983.1 - 0.91 8.9 9.9 1.3 8.3 9.9 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Striatin PF08232.12 ETO16983.1 - 2.1 8.9 6.7 2.7 8.6 6.7 1.4 1 1 0 1 1 1 0 Striatin family DUF2722 PF10846.8 ETO16983.1 - 5.8 5.8 14.8 7.8 5.3 14.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Nop14 PF04147.12 ETO16983.1 - 6.1 4.9 17.4 7.7 4.6 17.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF2457 PF10446.9 ETO16983.1 - 6.6 5.8 23.3 9.6 5.2 23.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF3361 PF11841.8 ETO16984.1 - 3.9e-05 23.6 5.6 0.085 12.8 0.0 4.4 4 1 1 5 5 5 2 Domain of unknown function (DUF3361) Arm PF00514.23 ETO16984.1 - 0.0003 20.7 5.1 2.1 8.5 0.0 6.0 6 1 1 7 7 7 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ETO16984.1 - 0.0017 18.3 7.8 0.36 10.9 0.2 5.2 6 0 0 6 6 6 1 Spinocerebellar ataxia type 10 protein domain WAPL PF07814.13 ETO16984.1 - 0.0098 14.7 2.9 0.01 14.6 0.2 2.3 2 1 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin Inj_translocase PF16928.5 ETO16984.1 - 0.055 12.9 0.2 0.13 11.7 0.2 1.6 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome UNC45-central PF11701.8 ETO16984.1 - 0.27 11.2 5.1 3.2 7.7 2.1 2.7 2 0 0 2 2 2 0 Myosin-binding striated muscle assembly central WW PF00397.26 ETO16985.1 - 0.00026 21.0 0.2 0.00054 20.0 0.2 1.5 1 0 0 1 1 1 1 WW domain EPL1 PF10513.9 ETO16985.1 - 0.0022 18.4 6.2 0.0022 18.4 6.2 1.5 2 0 0 2 2 2 1 Enhancer of polycomb-like zf-RanBP PF00641.18 ETO16985.1 - 0.0057 15.9 5.4 0.011 15.0 5.4 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RNA_POL_M_15KD PF02150.16 ETO16985.1 - 0.015 15.1 0.2 0.015 15.1 0.2 2.4 1 1 1 2 2 2 0 RNA polymerases M/15 Kd subunit Cwf_Cwc_15 PF04889.12 ETO16985.1 - 0.053 13.3 11.7 0.069 12.9 11.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Vps36-NZF-N PF16988.5 ETO16985.1 - 0.054 12.9 1.3 0.054 12.9 1.3 2.1 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain RAP1 PF07218.11 ETO16985.1 - 0.06 11.6 8.1 0.077 11.3 8.1 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Presenilin PF01080.17 ETO16985.1 - 4.6 5.9 6.0 4.6 5.9 6.0 1.2 1 0 0 1 1 1 0 Presenilin zinc_ribbon_2 PF13240.6 ETO16985.1 - 6.7 6.6 6.2 5.7 6.8 4.1 2.1 2 0 0 2 2 2 0 zinc-ribbon domain ADK PF00406.22 ETO16986.1 - 3e-36 124.8 0.0 3.9e-36 124.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETO16986.1 - 5.7e-17 62.4 0.0 9.5e-17 61.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain ADK_lid PF05191.14 ETO16986.1 - 3.3e-12 46.2 2.2 7.9e-12 45.0 2.2 1.7 1 0 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ETO16986.1 - 2.9e-07 31.1 0.0 1e-06 29.3 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO16986.1 - 8.4e-06 26.0 0.0 1.6e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETO16986.1 - 0.0008 19.2 0.0 0.0012 18.6 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain zf_C2H2_13 PF18508.1 ETO16986.1 - 0.0012 18.4 2.6 0.14 11.8 0.2 2.6 2 0 0 2 2 2 2 Zinc finger domain TerY_C PF15616.6 ETO16986.1 - 0.034 14.2 0.0 0.054 13.6 0.0 1.3 1 0 0 1 1 1 0 TerY-C metal binding domain Zeta_toxin PF06414.12 ETO16986.1 - 0.045 13.0 0.0 0.081 12.2 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin Cytidylate_kin PF02224.18 ETO16986.1 - 0.063 13.0 0.0 0.099 12.4 0.0 1.3 1 0 0 1 1 1 0 Cytidylate kinase XPA_N PF01286.18 ETO16986.1 - 0.11 12.6 0.3 17 5.6 0.0 2.7 2 0 0 2 2 2 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 ETO16986.1 - 0.16 12.1 1.1 0.51 10.5 1.1 1.8 1 0 0 1 1 1 0 Zinc ribbon domain Hydin_ADK PF17213.3 ETO16986.1 - 0.19 12.0 0.1 5.9 7.1 0.0 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Zn_ribbon_recom PF13408.6 ETO16986.1 - 0.32 11.6 1.6 1.4 9.5 1.6 2.1 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain WD40 PF00400.32 ETO16987.1 - 6.8e-35 118.5 8.3 1.4e-07 32.0 0.4 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16987.1 - 1.4e-16 60.5 0.2 0.11 12.8 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16987.1 - 1.5e-10 40.6 0.0 0.022 13.8 0.0 4.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO16987.1 - 6.1e-09 35.6 3.3 0.91 9.5 0.1 5.7 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO16987.1 - 9.8e-09 35.4 0.1 6.2e-05 23.0 0.0 3.0 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ETO16987.1 - 4.4e-08 32.6 0.6 1.2e-07 31.1 0.3 1.9 1 1 0 1 1 1 1 Coatomer WD associated region Nup160 PF11715.8 ETO16987.1 - 0.00047 18.9 0.5 0.71 8.5 0.1 3.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO16987.1 - 0.0028 17.7 0.1 3.1 7.9 0.1 3.2 1 1 2 3 3 3 1 Family of unknown function (DUF5570) DPPIV_N PF00930.21 ETO16987.1 - 0.01 14.6 0.2 11 4.7 0.0 4.0 2 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF2963 PF11178.8 ETO16987.1 - 0.036 13.8 7.9 7.5 6.3 0.0 5.2 5 2 0 5 5 5 0 Protein of unknown function (DUF2963) PQQ_2 PF13360.6 ETO16987.1 - 0.062 12.9 0.1 0.58 9.7 0.0 2.3 2 1 0 2 2 2 0 PQQ-like domain Proteasome_A_N PF10584.9 ETO16987.1 - 1.2 8.9 11.7 26 4.6 0.2 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature YojJ PF10372.9 ETO16989.1 - 0.039 14.1 0.9 0.13 12.4 0.5 2.1 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF2681 PF10883.8 ETO16989.1 - 0.064 13.7 0.3 0.064 13.7 0.3 3.4 2 2 1 3 3 3 0 Protein of unknown function (DUF2681) BRCT_2 PF16589.5 ETO16989.1 - 0.14 12.6 1.0 2.1 8.8 0.2 2.5 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain FAD-SLDH PF12318.8 ETO16989.1 - 0.55 10.3 3.7 2.9 7.9 0.2 2.5 2 1 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase Rsc14 PF08586.10 ETO16989.1 - 1 10.2 4.8 0.21 12.4 0.5 2.0 2 1 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit Kelch_6 PF13964.6 ETO16990.1 - 4.7e-06 26.7 1.5 0.049 13.9 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO16990.1 - 0.00031 20.7 2.1 0.028 14.4 0.3 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO16990.1 - 0.00087 18.8 4.9 0.48 10.1 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO16990.1 - 0.0012 18.7 5.2 0.05 13.6 0.1 4.5 6 1 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 ETO16990.1 - 0.0013 18.7 0.1 0.43 10.6 0.0 3.6 3 0 0 3 3 3 1 Galactose oxidase, central domain WD40 PF00400.32 ETO16991.1 - 1.9e-56 186.7 4.2 2.3e-09 37.7 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16991.1 - 6.2e-26 90.5 3.8 0.0016 18.7 0.0 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO16991.1 - 3.9e-17 62.2 0.2 0.0013 17.8 0.0 6.2 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO16991.1 - 1.4e-07 31.2 7.3 1.7 8.7 0.0 6.8 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO16991.1 - 1.6e-06 26.9 0.4 0.016 13.8 0.0 3.2 1 1 3 4 4 4 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO16991.1 - 2e-05 23.4 6.0 0.083 11.5 0.5 5.7 2 1 2 6 6 6 1 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO16991.1 - 0.0048 17.0 0.1 0.32 11.2 0.0 3.4 3 1 0 3 3 3 1 Strictosidine synthase Nbas_N PF15492.6 ETO16991.1 - 0.008 15.5 0.7 5 6.4 0.1 4.4 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO16991.1 - 0.012 15.2 0.0 5.9 6.4 0.0 2.6 1 1 0 2 2 2 0 PQQ-like domain DUF5570 PF17731.1 ETO16991.1 - 0.022 14.9 0.0 5.3 7.2 0.0 4.0 2 1 3 5 5 5 0 Family of unknown function (DUF5570) Methyltransf_3 PF01596.17 ETO16991.1 - 0.024 13.8 0.4 3.1 6.9 0.0 3.4 3 1 0 3 3 3 0 O-methyltransferase BBS2_Mid PF14783.6 ETO16991.1 - 0.076 13.1 7.1 0.29 11.2 1.4 4.3 2 2 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Proteasome_A_N PF10584.9 ETO16991.1 - 2.1 8.1 10.3 99 2.8 0.0 5.2 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO16992.1 - 2.1e-35 120.1 29.7 3.1e-08 34.1 2.5 6.8 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO16992.1 - 2.4e-08 34.1 3.1 0.19 12.1 0.0 5.1 2 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO16992.1 - 4.4e-05 22.3 8.3 0.21 10.2 0.1 4.5 2 2 3 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO16992.1 - 0.016 14.0 9.5 2.6 6.7 0.3 3.9 1 1 0 2 2 2 0 Nup133 N terminal like Acyltransferase PF01553.21 ETO16994.1 - 1.7e-13 50.3 0.0 2.6e-13 49.7 0.0 1.3 1 0 0 1 1 1 1 Acyltransferase EF-hand_1 PF00036.32 ETO16994.1 - 9.1e-06 24.9 0.3 2.2e-05 23.7 0.3 1.7 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ETO16994.1 - 4.3e-05 22.8 0.3 0.00011 21.5 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO16994.1 - 0.00043 20.0 0.3 0.0011 18.7 0.3 1.8 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETO16994.1 - 0.0013 19.1 0.0 0.0021 18.5 0.0 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ETO16994.1 - 0.0022 17.8 0.1 0.0042 16.9 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 ETO16996.1 - 9.2e-08 32.4 0.8 0.001 19.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO16996.1 - 1.6e-06 27.5 1.2 0.0023 17.7 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO16996.1 - 1.1e-05 24.6 0.4 0.0019 17.6 0.1 2.7 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 ETO16996.1 - 0.00078 18.8 0.3 0.0046 16.4 0.2 2.2 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO16996.1 - 0.0032 17.3 0.2 0.072 12.9 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO16996.1 - 0.56 10.5 3.5 8.1 6.8 0.6 3.3 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Phage_Gp23 PF10669.9 ETO16997.1 - 0.53 10.6 13.5 2.8 8.3 8.4 2.9 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) RNA_polI_A34 PF08208.11 ETO16997.1 - 3.7 7.6 17.8 0.32 11.1 11.3 2.3 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 GAGA_bind PF06217.12 ETO16998.1 - 0.09 13.1 3.7 0.11 12.8 3.7 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family BCAS2 PF05700.11 ETO16998.1 - 0.19 11.4 3.6 0.21 11.2 2.6 1.6 2 0 0 2 2 2 0 Breast carcinoma amplified sequence 2 (BCAS2) Ndc80_HEC PF03801.13 ETO16998.1 - 0.22 11.1 4.6 0.15 11.7 1.2 2.1 2 0 0 2 2 2 0 HEC/Ndc80p family FPRL1_inhibitor PF16104.5 ETO16999.1 - 0.084 13.0 0.2 0.13 12.4 0.2 1.2 1 0 0 1 1 1 0 Formyl peptide receptor-like 1 inhibitory protein FapA PF03961.13 ETO16999.1 - 0.28 9.7 3.9 0.38 9.3 3.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF572 PF04502.13 ETO17000.1 - 0.56 9.8 15.1 0.81 9.3 15.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) CENP-X PF09415.10 ETO17000.1 - 0.73 10.2 5.8 0.11 12.8 1.4 1.9 2 0 0 2 2 2 0 CENP-S associating Centromere protein X Tyrosinase PF00264.20 ETO17001.1 - 0.014 15.7 9.0 0.014 15.7 9.0 2.7 2 1 1 3 3 3 0 Common central domain of tyrosinase ABC_tran PF00005.27 ETO17002.1 - 3.5e-08 34.1 1.8 2.5e-07 31.3 0.1 2.1 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ETO17002.1 - 0.011 15.6 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ETO17002.1 - 0.021 14.5 0.0 0.021 14.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ETO17002.1 - 0.091 12.5 0.2 0.17 11.7 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_24 PF13479.6 ETO17002.1 - 0.17 11.6 0.0 0.17 11.6 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETO17002.1 - 0.21 12.1 0.1 0.21 12.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain Sec7_N PF12783.7 ETO17003.1 - 0.017 15.0 0.2 0.025 14.5 0.2 1.3 1 0 0 1 1 1 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Secretin_N_2 PF07655.13 ETO17003.1 - 0.17 12.5 8.7 0.32 11.6 8.7 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DnaJ_CXXCXGXG PF00684.19 ETO17004.1 - 7.9e-15 55.0 20.8 1.3e-14 54.3 20.8 1.3 1 0 0 1 1 1 1 DnaJ central domain FoP_duplication PF13865.6 ETO17004.1 - 0.0054 17.3 0.3 0.01 16.4 0.3 1.4 1 0 0 1 1 1 1 C-terminal duplication domain of Friend of PRMT1 Anti-TRAP PF15777.5 ETO17004.1 - 0.048 13.6 16.7 0.65 10.0 3.5 2.4 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein DnaJ_C PF01556.18 ETO17004.1 - 0.053 13.6 0.0 0.076 13.1 0.0 1.4 1 1 0 1 1 1 0 DnaJ C terminal domain A2L_zn_ribbon PF08792.10 ETO17004.1 - 0.31 10.8 0.3 0.31 10.8 0.3 3.7 3 1 1 4 4 4 0 A2L zinc ribbon domain TackOD1 PF18551.1 ETO17004.1 - 0.69 9.6 9.1 2.6 7.7 0.8 2.1 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 HypA PF01155.19 ETO17004.1 - 6.7 6.8 13.9 6.3 6.8 3.5 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DnaJ_C PF01556.18 ETO17005.1 - 3.6e-21 75.8 0.1 3.6e-21 75.8 0.1 1.6 2 0 0 2 2 2 1 DnaJ C terminal domain DUF167 PF02594.16 ETO17005.1 - 0.076 13.1 3.3 0.71 10.0 1.1 2.6 2 0 0 2 2 2 0 Uncharacterised ACR, YggU family COG1872 CRA PF06589.11 ETO17005.1 - 5.2 7.2 20.7 9.3 6.4 4.8 2.5 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) SUIM_assoc PF16619.5 ETO17006.1 - 0.49 10.5 11.1 1.1 9.4 11.1 1.5 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 ETO17006.1 - 1.1 8.8 10.5 2.2 7.9 10.5 1.4 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 ETO17006.1 - 8.2 5.4 6.5 11 5.0 6.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein SieB PF14163.6 ETO17007.1 - 0.15 11.6 0.6 0.23 10.9 0.6 1.3 1 0 0 1 1 1 0 Super-infection exclusion protein B CDC27 PF09507.10 ETO17009.1 - 2.8 7.2 52.6 4 6.7 52.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Macoilin PF09726.9 ETO17009.1 - 4.5 5.7 24.6 5.6 5.4 24.6 1.1 1 0 0 1 1 1 0 Macoilin family AF-4 PF05110.13 ETO17009.1 - 4.8 5.1 51.0 6.4 4.7 51.0 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Dapper PF15268.6 ETO17009.1 - 6.3 5.5 35.6 6.9 5.4 35.6 1.0 1 0 0 1 1 1 0 Dapper Mob1_phocein PF03637.17 ETO17010.1 - 2.7e-41 141.4 0.0 3.4e-41 141.1 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family DUF3602 PF12223.8 ETO17010.1 - 0.075 13.6 0.0 0.11 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3602) IFT57 PF10498.9 ETO17011.1 - 0.00061 18.9 3.6 0.00077 18.5 3.6 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 FapA PF03961.13 ETO17011.1 - 0.0019 16.9 4.5 0.002 16.8 4.5 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF5082 PF16888.5 ETO17011.1 - 0.0038 17.5 2.6 0.015 15.6 0.1 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF5082) PAXIP1_C PF15364.6 ETO17011.1 - 0.0053 17.1 0.7 0.0083 16.4 0.7 1.3 1 0 0 1 1 1 1 PAXIP1-associated-protein-1 C term PTIP binding protein DUF87 PF01935.17 ETO17011.1 - 0.0077 16.4 1.4 0.011 15.8 1.4 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain ApoLp-III PF07464.11 ETO17011.1 - 0.0088 16.1 0.9 0.013 15.5 0.9 1.3 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) CorA PF01544.18 ETO17011.1 - 0.011 15.1 0.6 0.017 14.4 0.6 1.3 1 1 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3584 PF12128.8 ETO17011.1 - 0.029 11.9 7.3 0.033 11.7 7.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF2524 PF10732.9 ETO17011.1 - 0.097 13.0 4.6 0.71 10.2 1.5 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) HIP1_clath_bdg PF16515.5 ETO17011.1 - 0.15 12.7 6.4 0.22 12.2 5.6 1.6 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF2884 PF11101.8 ETO17011.1 - 0.19 11.2 6.2 0.23 11.0 4.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2884) DUF725 PF05267.12 ETO17011.1 - 0.26 11.3 7.3 0.64 10.0 3.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF725) AAA_9 PF12781.7 ETO17011.1 - 0.3 10.2 6.7 0.24 10.5 4.6 1.7 1 1 1 2 2 2 0 ATP-binding dynein motor region Exonuc_VII_L PF02601.15 ETO17011.1 - 0.39 10.2 3.0 0.45 10.0 3.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ETO17011.1 - 0.41 10.0 4.3 0.51 9.6 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PRD PF00874.20 ETO17011.1 - 0.62 10.4 5.0 0.66 10.3 1.6 2.1 1 1 0 2 2 2 0 PRD domain OmpH PF03938.14 ETO17011.1 - 2.4 8.5 11.7 4.7 7.5 11.7 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) TMPIT PF07851.13 ETO17011.1 - 8.4 5.5 8.9 3.7 6.7 6.1 1.6 1 1 1 2 2 2 0 TMPIT-like protein uDENN PF03456.18 ETO17012.1 - 9.8e-11 42.3 0.0 7.7e-09 36.2 0.0 2.6 2 0 0 2 2 2 1 uDENN domain SRP54 PF00448.22 ETO17012.1 - 0.0021 17.7 0.0 0.0035 17.0 0.0 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain ArfGap PF01412.18 ETO17012.1 - 1.1 9.3 5.7 0.11 12.6 1.1 1.7 2 0 0 2 2 2 0 Putative GTPase activating protein for Arf Ras PF00071.22 ETO17014.1 - 3e-19 69.2 0.0 4.5e-19 68.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO17014.1 - 3e-07 30.7 0.0 4.8e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DLIC PF05783.11 ETO17014.1 - 0.00029 19.8 0.1 0.00065 18.7 0.0 1.5 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) Arf PF00025.21 ETO17014.1 - 0.0082 15.6 0.0 0.027 13.9 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF4272 PF14094.6 ETO17014.1 - 0.083 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4272) UCH PF00443.29 ETO17015.1 - 1.3e-10 41.2 0.3 3.2e-10 40.0 0.3 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Gtr1_RagA PF04670.12 ETO17015.1 - 0.075 12.4 1.2 0.26 10.6 1.2 1.9 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region HNH_3 PF13392.6 ETO17015.1 - 0.11 12.2 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 HNH endonuclease UCH PF00443.29 ETO17016.1 - 1.7e-08 34.3 0.0 4e-08 33.1 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO17016.1 - 4.7 6.7 12.0 60 3.1 12.0 2.8 1 1 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ETO17017.1 - 1.8e-61 202.6 13.1 3.2e-11 43.6 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17017.1 - 2.9e-17 62.8 0.3 6.5e-05 23.2 0.0 5.0 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17017.1 - 2.8e-12 46.3 0.2 0.023 13.7 0.0 5.3 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO17017.1 - 3.1e-11 43.5 0.0 5.2e-07 29.7 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO17017.1 - 1.3e-06 27.2 0.0 0.026 13.0 0.0 2.1 2 0 0 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO17017.1 - 1.3e-05 25.2 0.4 0.18 11.9 0.0 3.4 2 1 1 3 3 3 2 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO17017.1 - 6.6e-05 22.5 3.2 6.7 6.5 0.0 4.8 5 0 0 5 5 5 3 Proteasome subunit A N-terminal signature WD40_like PF17005.5 ETO17017.1 - 0.00012 21.6 0.4 0.04 13.2 0.0 3.0 2 2 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 ETO17017.1 - 0.00022 20.0 2.1 3.8 6.0 0.0 4.3 3 2 1 4 4 4 1 Nucleoporin Nup120/160 PD40 PF07676.12 ETO17017.1 - 0.00023 21.0 1.6 2.1 8.4 0.0 4.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO17017.1 - 0.00067 19.3 0.0 0.47 10.0 0.0 2.3 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Nucleoporin_N PF08801.11 ETO17017.1 - 0.0013 17.6 2.5 8.2 5.0 0.1 4.3 1 1 1 3 3 3 1 Nup133 N terminal like Str_synth PF03088.16 ETO17017.1 - 0.005 16.9 0.5 15 5.8 0.1 4.3 3 2 1 4 4 4 0 Strictosidine synthase DUF4999 PF16390.5 ETO17017.1 - 0.053 13.8 0.1 10 6.5 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function SBD PF17882.1 ETO17017.1 - 0.064 13.1 0.1 2.5 7.9 0.0 2.8 1 1 2 3 3 3 0 OAA-family lectin sugar binding domain TFIIIC_delta PF12657.7 ETO17017.1 - 0.092 12.7 0.4 21 5.0 0.0 3.3 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term PQQ PF01011.21 ETO17017.1 - 0.12 12.3 0.0 59 3.8 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat UCH PF00443.29 ETO17018.1 - 5.7e-25 88.3 0.0 1.8e-24 86.7 0.0 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO17018.1 - 0.009 15.6 0.3 0.009 15.6 0.3 3.2 4 1 0 4 4 4 1 Ubiquitin carboxyl-terminal hydrolase DUF3671 PF12420.8 ETO17019.1 - 0.0004 20.4 0.6 0.0004 20.4 0.6 1.9 2 0 0 2 2 2 1 Protein of unknown function IBR PF01485.21 ETO17020.1 - 8.7e-05 22.7 10.1 8.7e-05 22.7 10.1 2.7 2 2 0 3 3 3 1 IBR domain, a half RING-finger domain LIDHydrolase PF10230.9 ETO17020.1 - 0.078 12.5 0.0 0.092 12.3 0.0 1.2 1 0 0 1 1 1 0 Lipid-droplet associated hydrolase TniQ PF06527.11 ETO17020.1 - 1.9 9.2 8.9 5.5 7.7 4.0 2.4 2 1 0 2 2 2 0 TniQ Gp138_N PF18352.1 ETO17021.1 - 0.043 13.9 0.0 0.07 13.2 0.0 1.3 1 0 0 1 1 1 0 Phage protein Gp138 N-terminal domain UQ_con PF00179.26 ETO17022.1 - 0.0013 18.4 0.2 0.0038 16.9 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Med26_M PF15694.5 ETO17022.1 - 0.27 11.2 0.1 0.27 11.2 0.1 1.8 2 0 0 2 2 2 0 Mediator complex subunit 26 middle domain COPI_C PF06957.11 ETO17022.1 - 6.6 5.4 27.2 0.46 9.2 21.8 1.8 2 1 0 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus TFIIA PF03153.13 ETO17024.1 - 0.18 11.7 14.7 0.22 11.5 14.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF1765 PF08578.10 ETO17025.1 - 2.3e-15 57.1 1.2 2.3e-15 57.1 1.2 3.3 3 1 1 4 4 4 1 Protein of unknown function (DUF1765) RGS PF00615.19 ETO17026.1 - 0.00025 21.3 0.7 0.0038 17.5 0.7 2.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain Kinesin PF00225.23 ETO17027.1 - 2.5e-09 36.5 0.7 3.7e-09 35.9 0.7 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO17027.1 - 0.00018 21.5 0.7 0.00035 20.5 0.2 1.6 1 1 1 2 2 2 1 Microtubule binding DUF2420 PF10336.9 ETO17027.1 - 0.092 12.8 1.9 0.15 12.1 1.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2420) PPV_E2_C PF00511.17 ETO17028.1 - 0.18 12.0 0.3 0.18 12.0 0.3 1.8 2 0 0 2 2 2 0 E2 (early) protein, C terminal DUF4820 PF16091.5 ETO17028.1 - 0.46 9.8 7.6 0.48 9.8 6.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) PIP5K PF01504.18 ETO17029.1 - 2.9e-33 115.3 0.1 2.9e-33 115.3 0.1 1.6 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase NB PF04159.13 ETO17030.1 - 0.82 9.7 3.4 1.8 8.6 3.4 1.6 1 0 0 1 1 1 0 NB glycoprotein RGS PF00615.19 ETO17031.1 - 1.2e-10 41.6 0.6 2.3e-10 40.7 0.6 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain Actin PF00022.19 ETO17033.1 - 2.1e-13 49.6 0.0 2.2e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 Actin zf-CCHC PF00098.23 ETO17035.1 - 0.0049 16.9 0.7 0.0094 16.0 0.7 1.5 1 0 0 1 1 1 1 Zinc knuckle Flag1_repress PF03614.13 ETO17035.1 - 0.024 14.4 1.3 0.035 13.9 1.3 1.3 1 0 0 1 1 1 0 Repressor of phase-1 flagellin zf-CCHC_4 PF14392.6 ETO17035.1 - 0.066 12.9 1.0 0.14 11.9 0.4 1.8 2 0 0 2 2 2 0 Zinc knuckle zf-CCHC_3 PF13917.6 ETO17035.1 - 0.081 12.9 1.9 0.18 11.8 1.9 1.6 1 0 0 1 1 1 0 Zinc knuckle DUF641 PF04859.12 ETO17039.1 - 0.00031 21.1 15.7 0.01 16.2 0.7 2.1 2 0 0 2 2 2 2 Plant protein of unknown function (DUF641) AAA_13 PF13166.6 ETO17039.1 - 0.0088 14.7 17.5 0.011 14.4 17.5 1.1 1 0 0 1 1 1 1 AAA domain Lebercilin PF15619.6 ETO17039.1 - 0.012 15.2 24.1 0.55 9.9 0.2 2.0 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease CortBP2 PF09727.9 ETO17039.1 - 0.016 15.1 20.6 0.011 15.7 18.9 1.6 1 1 0 1 1 1 0 Cortactin-binding protein-2 Jnk-SapK_ap_N PF09744.9 ETO17039.1 - 0.21 11.8 23.1 0.68 10.1 14.1 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Uso1_p115_C PF04871.13 ETO17039.1 - 0.33 11.3 27.7 1.8 9.0 25.0 2.7 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region OmpH PF03938.14 ETO17039.1 - 0.35 11.2 32.1 1.5 9.2 25.0 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 ETO17039.1 - 0.57 9.5 19.0 1.4 8.2 19.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) MscS_porin PF12795.7 ETO17039.1 - 0.67 9.5 23.5 0.85 9.1 2.7 2.9 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Utp11 PF03998.13 ETO17039.1 - 0.82 9.6 23.1 0.94 9.4 23.1 1.1 1 0 0 1 1 1 0 Utp11 protein PRKG1_interact PF15898.5 ETO17039.1 - 0.88 10.5 20.7 5.2 8.0 1.4 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain TPR_MLP1_2 PF07926.12 ETO17039.1 - 1.1 9.3 27.4 13 5.8 0.5 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ETO17039.1 - 1.1 8.0 22.9 1.5 7.6 18.1 2.1 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF4047 PF13256.6 ETO17039.1 - 1.2 9.3 17.2 0.64 10.2 12.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Cep57_CLD PF14073.6 ETO17039.1 - 1.3 9.0 25.0 4.3 7.3 24.6 1.8 1 1 0 1 1 1 0 Centrosome localisation domain of Cep57 DUF755 PF05501.11 ETO17039.1 - 1.6 9.0 22.7 6.7 7.0 15.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF755) FAM76 PF16046.5 ETO17039.1 - 3.7 6.8 24.0 0.089 12.1 6.1 2.0 1 1 1 2 2 2 0 FAM76 protein DUF3450 PF11932.8 ETO17039.1 - 4.5 6.5 23.0 1.2 8.4 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Vir_act_alpha_C PF10400.9 ETO17039.1 - 8 7.2 8.7 14 6.4 0.6 2.4 1 1 1 2 2 2 0 Virulence activator alpha C-term DENN PF02141.21 ETO17041.1 - 0.00034 20.6 0.0 0.00042 20.3 0.0 1.2 1 0 0 1 1 1 1 DENN (AEX-3) domain Tctex-1 PF03645.13 ETO17041.1 - 0.002 18.3 0.3 0.0025 18.0 0.3 1.1 1 0 0 1 1 1 1 Tctex-1 family Pept_S41_N PF18294.1 ETO17043.1 - 0.082 12.9 0.5 0.88 9.6 0.0 2.2 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain CDC45 PF02724.14 ETO17044.1 - 0.00021 19.7 6.2 0.00021 19.7 6.2 1.0 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 ETO17044.1 - 0.0031 17.0 8.0 0.0031 17.0 8.0 1.0 1 0 0 1 1 1 1 SDA1 DUF4746 PF15928.5 ETO17044.1 - 0.0047 16.4 4.5 0.0055 16.2 4.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) Spore_coat_CotO PF14153.6 ETO17044.1 - 0.093 12.6 5.3 0.11 12.4 5.3 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Trypan_PARP PF05887.11 ETO17044.1 - 0.23 11.4 8.1 0.32 11.0 8.1 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) EIIBC-GUT_N PF03612.14 ETO17044.1 - 0.25 11.0 2.0 1.1 9.0 2.0 1.8 1 1 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Zip PF02535.22 ETO17044.1 - 0.26 10.5 2.5 0.29 10.3 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO17044.1 - 1.3 7.8 5.4 1.4 7.6 5.4 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO17044.1 - 1.8 6.7 13.3 1.9 6.6 13.3 1.0 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 ETO17044.1 - 8.3 5.7 14.1 11 5.3 14.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PQ-loop PF04193.14 ETO17045.1 - 6.5e-32 109.1 16.5 4.8e-17 61.5 3.6 3.2 3 0 0 3 3 3 2 PQ loop repeat Pox_A14 PF05767.12 ETO17045.1 - 0.0096 16.1 0.3 0.0096 16.1 0.3 2.9 2 1 1 3 3 3 1 Poxvirus virion envelope protein A14 DUF986 PF06173.12 ETO17045.1 - 1.1 9.4 8.4 0.11 12.6 3.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF986) Na_Ca_ex PF01699.24 ETO17045.1 - 2.4 8.1 16.1 0.71 9.8 2.9 2.5 2 1 0 2 2 2 0 Sodium/calcium exchanger protein CENP-B_dimeris PF09026.10 ETO17046.1 - 1.7 9.1 8.0 0.2 12.1 2.6 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain zf-C2H2 PF00096.26 ETO17047.1 - 1.3e-05 25.3 8.3 0.025 15.0 0.2 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO17047.1 - 8.5e-05 22.8 6.8 1 9.9 0.4 3.9 3 0 0 3 3 3 3 Zinc-finger double domain zf-BED PF02892.15 ETO17047.1 - 0.0037 17.2 3.7 0.0099 15.9 3.7 1.7 1 0 0 1 1 1 1 BED zinc finger zf-C2H2_4 PF13894.6 ETO17047.1 - 0.0059 17.4 11.7 0.081 13.8 1.9 2.8 3 0 0 3 3 3 2 C2H2-type zinc finger DUF2281 PF10047.9 ETO17047.1 - 0.47 11.2 3.1 30 5.4 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2281) zf-C2HE PF16278.5 ETO17047.1 - 0.84 10.1 5.7 2.1 8.8 5.7 1.9 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger DUF2368 PF10166.9 ETO17047.1 - 3.2 7.4 4.6 0.39 10.3 0.4 1.6 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2368) DUF1201 PF06716.11 ETO17050.1 - 0.023 14.7 0.1 0.045 13.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) Hormone_recep PF00104.30 ETO17050.1 - 0.1 12.2 0.2 0.19 11.3 0.2 1.4 1 0 0 1 1 1 0 Ligand-binding domain of nuclear hormone receptor PhoU PF01895.19 ETO17050.1 - 0.37 11.3 2.2 3 8.4 1.1 2.5 2 0 0 2 2 2 0 PhoU domain DUF4441 PF14536.6 ETO17051.1 - 0.46 10.7 10.8 0.74 10.0 5.2 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4441) PA28_beta PF02252.18 ETO17051.1 - 2.9 7.6 7.3 1.3 8.7 0.1 2.7 3 0 0 3 3 3 0 Proteasome activator pa28 beta subunit Josephin PF02099.17 ETO17052.1 - 1.8e-12 47.7 0.8 2.2e-12 47.4 0.8 1.1 1 0 0 1 1 1 1 Josephin Vps35 PF03635.17 ETO17053.1 - 1.8e-60 205.3 8.5 2e-60 205.2 8.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 SPATA6 PF14909.6 ETO17053.1 - 0.096 12.8 1.3 0.69 10.1 0.4 2.1 1 1 0 2 2 2 0 Spermatogenesis-assoc protein 6 MG4 PF17789.1 ETO17054.1 - 2.1 8.6 5.5 2.2 8.5 3.1 2.2 2 0 0 2 2 2 0 Macroglobulin domain MG4 YabA PF06156.13 ETO17054.1 - 7.2 7.3 8.5 1.5 9.5 1.1 2.5 2 1 1 3 3 3 0 Initiation control protein YabA zf-U1 PF06220.12 ETO17055.1 - 1.1e-07 31.5 1.0 1.1e-07 31.5 1.0 1.8 2 0 0 2 2 2 1 U1 zinc finger AKAP95 PF04988.12 ETO17055.1 - 0.001 19.3 1.1 0.0019 18.4 1.1 1.5 1 0 0 1 1 1 1 A-kinase anchoring protein 95 (AKAP95) D5_N PF08706.11 ETO17055.1 - 0.032 14.5 0.0 0.063 13.6 0.0 1.5 1 1 0 1 1 1 0 D5 N terminal like PTR PF12789.7 ETO17055.1 - 0.046 13.8 1.5 0.1 12.7 1.5 1.6 1 0 0 1 1 1 0 Phage tail repeat like TPR_11 PF13414.6 ETO17056.1 - 6.5e-05 22.5 7.4 0.00012 21.7 0.7 3.2 2 1 1 3 3 3 1 TPR repeat TPR_17 PF13431.6 ETO17056.1 - 0.027 14.8 0.6 0.027 14.8 0.6 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17056.1 - 0.06 13.5 3.9 0.38 11.0 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17056.1 - 1.2 9.1 7.9 8.8 6.3 0.5 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat PRY PF13765.6 ETO17057.1 - 0.099 12.3 0.0 12 5.6 0.0 2.7 2 0 0 2 2 2 0 SPRY-associated domain DUF4024 PF13216.6 ETO17057.1 - 2.1 8.3 7.1 3.6 7.6 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4024) Sulfatase PF00884.23 ETO17058.1 - 9.1e-31 107.4 0.0 1.2e-30 106.9 0.0 1.1 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 ETO17058.1 - 0.02 15.7 0.0 0.032 15.0 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase DUF4994 PF16385.5 ETO17058.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function Exostosin PF03016.15 ETO17060.1 - 6.5e-14 51.8 0.2 1.9e-13 50.3 0.0 1.7 2 0 0 2 2 2 1 Exostosin family COX6B PF02297.17 ETO17063.1 - 0.0062 16.8 3.6 0.017 15.4 3.6 1.7 1 0 0 1 1 1 1 Cytochrome oxidase c subunit VIb Rib PF08428.10 ETO17063.1 - 0.17 11.9 0.4 0.38 10.8 0.4 1.7 1 0 0 1 1 1 0 Rib/alpha-like repeat U1snRNP70_N PF12220.8 ETO17063.1 - 2.4 8.8 8.0 0.61 10.8 1.3 2.6 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal WD40 PF00400.32 ETO17064.1 - 0.0004 21.1 8.0 0.077 13.9 0.1 3.7 4 1 0 4 4 4 2 WD domain, G-beta repeat ICMT PF04140.14 ETO17064.1 - 0.015 15.7 0.8 0.024 15.1 0.1 1.7 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF2171 PF09939.9 ETO17065.1 - 0.018 15.3 0.7 0.034 14.4 0.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2171) Lyase_catalyt PF09093.11 ETO17065.1 - 0.032 13.4 6.0 0.032 13.4 6.0 1.0 1 0 0 1 1 1 0 Lyase, catalytic IRF PF00605.17 ETO17065.1 - 0.068 13.5 15.5 0.085 13.1 15.5 1.1 1 0 0 1 1 1 0 Interferon regulatory factor transcription factor Connexin PF00029.19 ETO17065.1 - 0.3 10.8 7.6 0.4 10.4 7.6 1.2 1 0 0 1 1 1 0 Connexin Serinc PF03348.15 ETO17065.1 - 0.53 9.2 4.4 0.61 9.0 4.4 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4569 PF15133.6 ETO17065.1 - 0.57 9.8 12.3 0.71 9.5 12.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Peroxin-13_N PF04088.13 ETO17065.1 - 1.6 9.0 15.4 0.64 10.3 9.8 1.9 1 1 1 2 2 2 0 Peroxin 13, N-terminal region SID-1_RNA_chan PF13965.6 ETO17065.1 - 1.6 7.1 8.9 1.7 7.0 8.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ERG2_Sigma1R PF04622.12 ETO17065.1 - 2.2 7.5 5.4 2.7 7.3 5.4 1.1 1 0 0 1 1 1 0 ERG2 and Sigma1 receptor like protein HCO3_cotransp PF00955.21 ETO17065.1 - 4.1 6.1 7.1 4.5 6.0 7.1 1.0 1 0 0 1 1 1 0 HCO3- transporter family Es2 PF09751.9 ETO17065.1 - 4.1 7.0 13.9 5 6.8 13.9 1.1 1 0 0 1 1 1 0 Nuclear protein Es2 DUF2228 PF10228.9 ETO17065.1 - 5.3 6.7 14.9 6.6 6.4 14.9 1.2 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2228) FAM176 PF14851.6 ETO17065.1 - 6 6.5 6.9 16 5.2 7.0 1.6 1 1 0 1 1 1 0 FAM176 family CLN3 PF02487.17 ETO17065.1 - 6.8 5.6 7.7 7.8 5.4 7.7 1.0 1 0 0 1 1 1 0 CLN3 protein Presenilin PF01080.17 ETO17065.1 - 10 4.8 9.7 12 4.6 9.7 1.0 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO17066.1 - 4.6e-40 134.9 24.6 1.7e-07 31.8 1.4 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO17066.1 - 2.1e-13 49.8 8.1 0.0034 16.1 0.1 5.4 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO17066.1 - 5.9e-13 48.9 2.2 0.053 13.8 0.0 5.7 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO17066.1 - 2.7e-06 26.9 7.6 0.00072 19.0 0.2 4.4 3 1 2 5 5 5 2 WD40-like domain Nucleoporin_N PF08801.11 ETO17066.1 - 0.00065 18.6 10.2 0.011 14.6 4.3 4.0 2 2 2 4 4 4 2 Nup133 N terminal like zf-C2H2_4 PF13894.6 ETO17067.1 - 0.00028 21.5 2.4 0.0021 18.7 1.7 2.6 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO17067.1 - 0.00031 21.0 3.1 0.00098 19.5 3.1 1.9 1 0 0 1 1 1 1 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 ETO17067.1 - 0.0021 18.5 1.0 0.56 10.7 0.3 2.6 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain RNF220 PF15926.5 ETO17067.1 - 0.012 15.3 0.0 0.013 15.2 0.0 1.1 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 zf-C2H2_2 PF12756.7 ETO17067.1 - 0.014 15.7 4.6 0.02 15.2 4.2 1.5 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) GAGA PF09237.11 ETO17067.1 - 0.016 15.0 0.1 0.032 14.0 0.1 1.5 1 0 0 1 1 1 0 GAGA factor Rad50_zn_hook PF04423.14 ETO17067.1 - 0.016 15.1 0.3 0.036 13.9 0.3 1.6 1 0 0 1 1 1 0 Rad50 zinc hook motif zf-C2H2_9 PF16293.5 ETO17067.1 - 0.019 14.8 0.1 0.041 13.7 0.1 1.5 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) Prok-RING_4 PF14447.6 ETO17067.1 - 0.031 14.2 0.3 0.076 12.9 0.3 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-LITAF-like PF10601.9 ETO17067.1 - 0.031 14.5 1.3 0.06 13.6 1.3 1.5 1 1 0 1 1 1 0 LITAF-like zinc ribbon domain Ntox21 PF15526.6 ETO17067.1 - 0.047 14.0 1.5 0.091 13.1 1.5 1.5 1 0 0 1 1 1 0 Novel toxin 21 zf-Di19 PF05605.12 ETO17067.1 - 0.055 13.8 0.5 0.1 12.9 0.5 1.6 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding UBZ_FAAP20 PF15750.5 ETO17067.1 - 0.19 11.7 0.2 0.19 11.7 0.2 2.2 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zf-H2C2_2 PF13465.6 ETO17067.1 - 0.21 12.1 12.5 0.94 10.0 6.1 2.7 2 1 0 2 2 2 0 Zinc-finger double domain Proteasome PF00227.26 ETO17068.1 - 1.8e-47 161.3 0.5 5e-47 159.9 0.5 1.8 1 0 0 1 1 1 1 Proteasome subunit Guanylate_kin PF00625.21 ETO17068.1 - 5.7e-19 68.5 0.0 1.4e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Guanylate kinase G-alpha PF00503.20 ETO17068.1 - 9e-16 58.0 2.7 9e-16 58.0 2.7 3.2 3 2 0 3 3 3 1 G-protein alpha subunit AAA PF00004.29 ETO17068.1 - 0.0012 19.2 0.5 1.2 9.5 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO17068.1 - 0.0022 18.3 0.1 0.082 13.2 0.0 3.1 3 1 0 3 3 3 1 AAA domain AAA_18 PF13238.6 ETO17068.1 - 0.008 16.7 0.0 0.033 14.7 0.0 2.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO17068.1 - 0.028 14.3 0.0 2.3 8.1 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase AAA_33 PF13671.6 ETO17068.1 - 0.068 13.3 0.0 0.21 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ETO17068.1 - 0.16 12.2 1.1 19 5.5 0.0 3.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETO17068.1 - 0.77 10.3 3.6 3.3 8.2 0.0 3.5 4 0 0 4 4 4 0 ABC transporter Deltameth_res PF16020.5 ETO17070.1 - 0.023 14.6 0.0 0.044 13.7 0.0 1.5 1 0 0 1 1 1 0 Deltamethrin resistance PGG PF13962.6 ETO17070.1 - 0.025 14.4 0.2 0.53 10.1 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function Ge1_WD40 PF16529.5 ETO17072.1 - 0.036 13.0 5.3 0.07 12.1 5.1 1.6 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 ETO17072.1 - 0.31 12.0 9.6 4.8 8.2 2.4 4.1 3 2 0 3 3 3 0 WD domain, G-beta repeat WD40 PF00400.32 ETO17073.1 - 1.3e-10 41.6 4.6 8.3e-07 29.6 1.2 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17073.1 - 0.0013 19.0 0.7 0.028 14.7 0.3 2.6 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Mucin PF01456.17 ETO17073.1 - 0.018 15.0 14.3 0.022 14.7 14.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 ETO17073.1 - 0.31 9.1 7.0 0.35 9.0 7.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 ETO17073.1 - 0.45 8.7 13.4 0.53 8.4 13.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO17073.1 - 4 7.4 11.3 6.4 6.8 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CPSF100_C PF13299.6 ETO17074.1 - 0.17 12.1 10.6 0.3 11.2 10.6 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 ETO17074.1 - 4.3 6.5 5.2 6.3 5.9 5.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Paramyxo_ncap PF00973.19 ETO17074.1 - 6.1 5.6 10.9 10 4.9 10.9 1.3 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CLASP_N PF12348.8 ETO17075.1 - 1.7e-14 54.0 1.8 1.7e-14 54.0 1.8 2.1 2 0 0 2 2 2 1 CLASP N terminal EF-hand_1 PF00036.32 ETO17075.1 - 6.3e-14 50.4 5.0 0.0032 16.9 0.5 5.5 5 0 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 ETO17075.1 - 2.2e-10 39.6 5.2 0.021 14.7 0.4 5.1 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 ETO17075.1 - 1.1e-08 34.8 4.3 0.00096 19.0 0.0 4.7 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_7 PF13499.6 ETO17075.1 - 2e-07 31.3 10.1 0.0026 18.2 0.1 5.2 5 1 1 6 6 6 4 EF-hand domain pair RXLR PF16810.5 ETO17075.1 - 0.055 13.9 8.0 0.58 10.6 4.4 3.1 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity p25-alpha PF05517.12 ETO17075.1 - 0.081 13.1 0.3 0.081 13.1 0.3 4.4 5 0 0 5 5 5 0 p25-alpha zf-Nse PF11789.8 ETO17077.1 - 4.9e-13 48.7 0.0 1.1e-12 47.5 0.0 1.7 1 1 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Spore_permease PF03845.13 ETO17077.1 - 0.0014 17.6 2.5 0.002 17.0 2.5 1.2 1 0 0 1 1 1 1 Spore germination protein zf-MIZ PF02891.20 ETO17077.1 - 0.0034 17.1 5.2 0.015 15.1 5.2 2.0 1 1 0 1 1 1 1 MIZ/SP-RING zinc finger zf-RING_2 PF13639.6 ETO17077.1 - 0.045 14.1 0.4 0.14 12.5 0.4 1.8 1 1 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO17077.1 - 0.092 12.6 1.4 0.53 10.2 0.1 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO17077.1 - 0.15 12.1 0.0 0.15 12.1 0.0 2.0 2 0 0 2 2 2 0 RING-type zinc-finger DUF1840 PF08895.11 ETO17077.1 - 0.16 12.3 2.4 2.2 8.6 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) SR-25 PF10500.9 ETO17077.1 - 1.4 8.5 16.1 0.095 12.3 11.2 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein zf-tcix PF14952.6 ETO17077.1 - 7 6.4 8.8 24 4.7 0.1 2.3 2 0 0 2 2 2 0 Putative treble-clef, zinc-finger, Zn-binding DUF2203 PF09969.9 ETO17078.1 - 6.7e-05 23.6 5.0 0.26 12.0 1.6 2.9 3 1 0 3 3 2 2 Uncharacterized conserved protein (DUF2203) Syntaxin PF00804.25 ETO17078.1 - 0.003 17.3 2.1 0.003 17.3 2.1 2.7 2 1 2 4 4 4 1 Syntaxin Glyco_hydro_67C PF07477.12 ETO17078.1 - 0.0062 16.1 1.6 2.3 7.7 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 67 C-terminus Apolipoprotein PF01442.18 ETO17078.1 - 0.0067 16.3 5.3 1.2 9.0 2.2 2.6 2 1 0 2 2 2 2 Apolipoprotein A1/A4/E domain BLOC1_2 PF10046.9 ETO17078.1 - 0.041 14.2 9.7 2.9 8.2 1.2 3.8 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Glyco_hydro_25 PF01183.20 ETO17078.1 - 0.065 13.4 1.9 7.4 6.7 0.1 2.7 2 1 1 3 3 3 0 Glycosyl hydrolases family 25 CheZ PF04344.13 ETO17078.1 - 0.069 13.1 8.8 0.06 13.3 1.2 2.6 1 1 2 3 3 3 0 Chemotaxis phosphatase, CheZ DUF5063 PF16702.5 ETO17078.1 - 0.069 13.5 0.5 0.15 12.5 0.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5063) CENP-Q PF13094.6 ETO17078.1 - 0.081 13.1 0.3 0.081 13.1 0.3 2.9 2 1 0 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.12 ETO17078.1 - 0.082 12.9 7.0 4.9 7.2 0.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) IL4 PF00727.18 ETO17078.1 - 0.088 13.0 2.3 0.44 10.8 0.3 2.7 2 1 0 2 2 2 0 Interleukin 4 DUF948 PF06103.11 ETO17078.1 - 0.093 13.0 2.6 5.1 7.4 0.1 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF2935 PF11155.8 ETO17078.1 - 0.13 12.6 2.2 0.82 10.0 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF2935) Rx_N PF18052.1 ETO17078.1 - 0.15 12.4 6.2 0.15 12.3 1.5 2.8 3 1 0 3 3 2 0 Rx N-terminal domain Fib_alpha PF08702.10 ETO17078.1 - 0.17 12.0 11.5 0.13 12.4 4.5 2.8 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family TMPIT PF07851.13 ETO17078.1 - 0.32 10.2 9.0 1.4 8.1 4.2 2.4 1 1 1 2 2 2 0 TMPIT-like protein KxDL PF10241.9 ETO17078.1 - 0.32 11.3 0.1 0.32 11.3 0.1 3.8 3 1 0 3 3 3 0 Uncharacterized conserved protein DUF745 PF05335.13 ETO17078.1 - 0.75 9.5 9.9 0.46 10.2 0.5 3.1 1 1 1 2 2 2 0 Protein of unknown function (DUF745) PCRF PF03462.18 ETO17078.1 - 0.8 9.5 9.9 0.22 11.4 3.7 2.4 1 1 0 2 2 2 0 PCRF domain TPR_MLP1_2 PF07926.12 ETO17078.1 - 1.2 9.2 17.3 0.47 10.5 7.4 3.3 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein CRR7 PF12095.8 ETO17078.1 - 1.5 9.3 5.8 2.6 8.5 0.2 3.0 3 0 0 3 3 3 0 Protein CHLORORESPIRATORY REDUCTION 7 DUF4795 PF16043.5 ETO17078.1 - 1.7 8.2 11.1 0.27 10.8 4.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) V-SNARE PF05008.15 ETO17078.1 - 3.4 8.1 11.0 1 9.7 0.6 3.9 3 1 1 4 4 4 0 Vesicle transport v-SNARE protein N-terminus YabA PF06156.13 ETO17078.1 - 6.6 7.4 12.4 6.3 7.5 0.6 3.7 1 1 3 4 4 4 0 Initiation control protein YabA Muted PF14942.6 ETO17078.1 - 6.7 7.0 18.1 1.1 9.6 4.0 3.3 1 1 2 3 3 3 0 Organelle biogenesis, Muted-like protein DUF2408 PF10303.9 ETO17078.1 - 8.4 7.0 10.3 4.9 7.7 7.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2408) TPR_1 PF00515.28 ETO17080.1 - 4.6e-06 26.2 0.2 0.014 15.2 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17080.1 - 0.00031 20.9 1.5 0.51 10.8 0.0 3.2 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17080.1 - 0.0011 18.9 0.1 0.63 10.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17080.1 - 0.015 15.3 0.2 0.22 11.7 0.0 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17080.1 - 0.072 13.3 0.1 13 6.3 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17080.1 - 0.12 12.3 0.8 0.32 10.9 0.4 2.1 2 1 0 2 2 2 0 Tetratricopeptide repeat Ribosomal_L39 PF00832.20 ETO17081.1 - 0.17 11.5 4.4 0.35 10.5 4.4 1.5 1 0 0 1 1 1 0 Ribosomal L39 protein RabGAP-TBC PF00566.18 ETO17082.1 - 7.1e-22 78.1 4.8 3.7e-19 69.3 0.1 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain Dicty_REP PF05086.12 ETO17082.1 - 0.3 9.0 6.2 0.38 8.7 6.2 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4615 PF15393.6 ETO17082.1 - 1.4 9.5 10.7 0.41 11.2 6.3 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4615) PIP5K PF01504.18 ETO17084.1 - 5.5e-32 111.1 0.0 6.3e-32 110.9 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Protocadherin PF08374.11 ETO17085.1 - 0.079 12.9 2.9 0.1 12.5 2.9 1.3 1 0 0 1 1 1 0 Protocadherin Neur_chan_memb PF02932.16 ETO17085.1 - 0.37 10.8 9.4 0.65 10.0 9.4 1.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pneumovirus_M2 PF06436.11 ETO17085.1 - 0.44 10.0 0.0 0.44 10.0 0.0 2.4 2 1 0 2 2 2 0 Pneumovirus matrix protein 2 (M2) RNA_pol_Rpb1_5 PF04998.17 ETO17085.1 - 1.7 8.0 6.3 2.1 7.7 6.3 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Aida_N PF08910.10 ETO17085.1 - 2.4 8.6 6.5 4.2 7.8 5.9 1.6 2 0 0 2 2 2 0 Aida N-terminus CpcD PF01383.21 ETO17087.1 - 0.079 13.2 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 CpcD/allophycocyanin linker domain Rab5-bind PF09311.11 ETO17089.1 - 0.092 12.1 0.5 0.13 11.6 0.5 1.1 1 0 0 1 1 1 0 Rabaptin-like protein Cpn60_TCP1 PF00118.24 ETO17090.1 - 2.7e-17 62.6 0.4 3.2e-17 62.3 0.4 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family GTP-bdg_M PF16360.5 ETO17090.1 - 0.028 15.0 2.7 0.34 11.5 0.5 2.4 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region VGPC1_C PF16799.5 ETO17090.1 - 0.094 12.7 0.0 0.19 11.7 0.0 1.5 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 TrmE_N PF10396.9 ETO17090.1 - 0.16 12.3 0.1 3.1 8.2 0.0 2.2 2 0 0 2 2 2 0 GTP-binding protein TrmE N-terminus Oxysterol_BP PF01237.18 ETO17091.1 - 0.0015 17.4 4.5 0.0021 17.0 4.5 1.2 1 0 0 1 1 1 1 Oxysterol-binding protein Secretin_N_2 PF07655.13 ETO17092.1 - 0.024 15.2 11.2 0.024 15.2 11.2 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain OB_aCoA_assoc PF01796.17 ETO17092.1 - 0.52 10.4 3.0 0.64 10.1 0.0 2.4 2 1 0 2 2 2 0 DUF35 OB-fold domain, acyl-CoA-associated Orf78 PF06024.12 ETO17092.1 - 7.3 7.0 10.0 3.7 7.9 4.5 2.7 2 0 0 2 2 2 0 Orf78 (ac78) CSRNP_N PF16019.5 ETO17094.1 - 0.0098 15.8 6.5 0.018 15.0 6.5 1.4 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus eIF_4EBP PF05456.11 ETO17094.1 - 0.02 14.8 0.4 0.045 13.7 0.4 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP) Nop14 PF04147.12 ETO17094.1 - 0.23 9.6 15.3 0.26 9.4 15.3 1.1 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO17094.1 - 1.2 7.8 6.8 25 3.5 7.9 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM76 PF16046.5 ETO17094.1 - 1.3 8.3 13.8 0.077 12.3 8.4 1.6 2 0 0 2 2 2 0 FAM76 protein Presenilin PF01080.17 ETO17094.1 - 7.1 5.3 5.0 8 5.1 5.0 1.2 1 0 0 1 1 1 0 Presenilin GOLD_2 PF13897.6 ETO17094.1 - 8.8 6.8 10.3 0.29 11.6 1.4 2.5 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking ERAP1_C PF11838.8 ETO17095.1 - 3.2e-20 72.9 0.9 6.5e-20 71.9 0.9 1.4 1 1 0 1 1 1 1 ERAP1-like C-terminal domain EIAV_GP90 PF00971.18 ETO17095.1 - 0.058 12.1 3.0 0.37 9.4 0.5 2.0 2 0 0 2 2 2 0 EIAV coat protein, gp90 DUF2673 PF10880.8 ETO17095.1 - 0.12 12.5 0.6 8.4 6.6 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2673) MIB_HERC2 PF06701.13 ETO17096.1 - 1.6e-30 105.2 22.2 1e-20 73.7 4.5 5.4 5 0 0 5 5 5 3 Mib_herc2 RhoGEF PF00621.20 ETO17097.1 - 7.7e-13 49.1 4.3 9.1e-13 48.8 4.3 1.1 1 0 0 1 1 1 1 RhoGEF domain PB1-F2 PF11986.8 ETO17098.1 - 0.063 13.5 3.5 0.092 13.0 3.5 1.3 1 1 0 1 1 1 0 Influenza A Proapoptotic protein CCDC53 PF10152.9 ETO17099.1 - 1.8e-10 41.4 16.0 3.1e-07 30.9 0.8 2.8 3 0 0 3 3 3 2 Subunit CCDC53 of WASH complex HlyD_D4 PF16572.5 ETO17099.1 - 0.0065 16.3 0.2 7.6 6.5 0.0 3.2 3 1 1 4 4 4 2 Long alpha hairpin domain of cation efflux system protein, CusB Zn_ribbon_2 PF12674.7 ETO17099.1 - 0.44 11.2 3.8 0.23 12.2 0.5 2.1 2 0 0 2 2 2 0 Putative zinc ribbon domain Exo_endo_phos PF03372.23 ETO17102.1 - 3e-18 66.2 0.0 9.5e-18 64.6 0.0 1.9 2 0 0 2 2 2 1 Endonuclease/Exonuclease/phosphatase family zf-C6H2 PF15801.5 ETO17102.1 - 7.7e-12 45.3 16.9 2e-11 44.0 16.9 1.8 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding Tim54 PF11711.8 ETO17102.1 - 0.016 14.0 4.2 0.033 13.0 4.2 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 zf-MYND PF01753.18 ETO17102.1 - 0.82 9.8 21.6 0.043 13.9 14.7 2.4 2 0 0 2 2 2 0 MYND finger CSG2 PF16965.5 ETO17102.1 - 6.4 5.6 7.5 2.1 7.2 2.6 2.2 2 0 0 2 2 2 0 Ceramide synthase regulator GP67 PF17634.2 ETO17103.1 - 0.35 11.3 0.2 0.35 11.3 0.2 2.2 2 0 0 2 2 2 0 Gene product 67 DNA_pol_phi PF04931.13 ETO17103.1 - 0.44 8.6 13.4 0.57 8.2 13.4 1.0 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ETO17103.1 - 1.4 9.3 23.4 0.4 11.1 14.7 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain SDA1 PF05285.12 ETO17103.1 - 1.5 8.1 6.6 1.9 7.8 6.6 1.1 1 0 0 1 1 1 0 SDA1 Utp14 PF04615.13 ETO17103.1 - 1.7 7.1 3.0 2.1 6.8 3.0 1.1 1 0 0 1 1 1 0 Utp14 protein Nop14 PF04147.12 ETO17103.1 - 2.4 6.3 4.2 3 5.9 4.2 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO17103.1 - 2.7 7.2 5.3 3.4 6.9 5.3 1.1 1 0 0 1 1 1 0 BUD22 WRNPLPNID PF15017.6 ETO17103.1 - 3.9 8.4 8.2 23 6.0 4.6 2.2 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box DUF1192 PF06698.11 ETO17104.1 - 0.35 10.9 8.1 1.9 8.6 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) PCM1_C PF15717.5 ETO17104.1 - 0.52 8.9 19.8 0.13 10.9 8.7 2.0 2 0 0 2 2 2 0 Pericentriolar material 1 C terminus ExsD PF16806.5 ETO17104.1 - 1.2 8.9 9.4 2.2 8.2 0.5 2.8 1 1 1 3 3 3 0 Antiactivator protein ExsD PAP1 PF08601.10 ETO17104.1 - 2.9 7.5 20.0 0.16 11.7 8.5 2.1 2 0 0 2 2 2 0 Transcription factor PAP1 SAM_2 PF07647.17 ETO17105.1 - 0.12 12.5 0.2 0.18 11.9 0.2 1.4 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 ETO17105.1 - 0.13 12.1 0.1 0.22 11.3 0.1 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Histidinol_dh PF00815.20 ETO17106.1 - 0.02 13.9 0.6 0.024 13.7 0.6 1.0 1 0 0 1 1 1 0 Histidinol dehydrogenase PRORP PF16953.5 ETO17106.1 - 0.061 12.8 0.8 0.074 12.6 0.8 1.1 1 0 0 1 1 1 0 Protein-only RNase P Pkinase PF00069.25 ETO17107.1 - 4.8e-27 95.0 0.0 9.3e-27 94.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain EF-hand_1 PF00036.32 ETO17107.1 - 1.1e-26 90.4 15.4 6.2e-07 28.5 0.8 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO17107.1 - 8.5e-24 83.8 8.3 1.4e-12 47.9 0.7 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO17107.1 - 1.4e-23 81.3 9.9 1.6e-05 24.2 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO17107.1 - 5.6e-22 75.8 12.2 3.8e-06 26.4 0.1 4.8 3 1 1 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ETO17107.1 - 1.4e-15 56.8 6.9 0.00025 20.8 0.2 4.4 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO17107.1 - 3.4e-10 40.2 1.4 0.00016 21.9 0.1 2.3 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Pkinase_Tyr PF07714.17 ETO17107.1 - 7e-07 28.8 0.0 2e-06 27.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase GHL13 PF14883.6 ETO17107.1 - 0.024 13.7 0.0 0.048 12.7 0.0 1.4 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 13 EF-hand_4 PF12763.7 ETO17107.1 - 0.036 14.0 5.6 0.92 9.5 0.5 3.3 1 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ETO17107.1 - 0.085 13.1 3.5 0.56 10.4 0.3 3.0 3 1 0 3 3 3 0 Dockerin type I domain EF-hand_10 PF14788.6 ETO17107.1 - 3.9 7.4 7.9 3.9 7.4 0.3 3.8 3 1 1 4 4 4 0 EF hand HALZ PF02183.18 ETO17108.1 - 0.0014 18.8 6.5 0.0014 18.8 6.5 2.3 3 0 0 3 3 3 1 Homeobox associated leucine zipper FapA PF03961.13 ETO17108.1 - 0.036 12.7 14.7 0.058 12.0 14.7 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1640 PF07798.11 ETO17108.1 - 0.45 10.5 17.9 0.39 10.8 9.8 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Lectin_N PF03954.14 ETO17108.1 - 0.76 9.5 8.6 3.7 7.3 1.2 2.5 2 1 0 2 2 2 0 Hepatic lectin, N-terminal domain DUF5320 PF17253.2 ETO17108.1 - 1.7 9.8 5.1 14 6.8 2.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) YabA PF06156.13 ETO17108.1 - 2.6 8.8 16.2 0.2 12.3 4.6 2.9 2 1 1 3 3 3 0 Initiation control protein YabA Jnk-SapK_ap_N PF09744.9 ETO17108.1 - 2.6 8.3 17.6 1 9.6 14.4 1.8 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 ZapB PF06005.12 ETO17108.1 - 3.9 8.0 21.6 0.065 13.7 6.5 2.8 1 1 1 2 2 2 0 Cell division protein ZapB CD36 PF01130.21 ETO17110.1 - 1.6e-06 26.9 1.6 1.6e-06 26.9 1.6 2.0 2 0 0 2 2 2 2 CD36 family Aa_trans PF01490.18 ETO17111.1 - 3.2e-09 36.0 5.1 9.5e-09 34.4 3.2 2.1 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein SARAF PF06682.12 ETO17111.1 - 0.017 14.8 2.5 2.9 7.4 0.0 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis TctB PF07331.11 ETO17111.1 - 0.05 13.9 6.1 0.97 9.7 1.3 3.0 3 0 0 3 3 3 0 Tripartite tricarboxylate transporter TctB family YMF19 PF02326.15 ETO17111.1 - 0.054 14.3 3.2 0.12 13.2 0.9 2.9 2 0 0 2 2 2 0 Plant ATP synthase F0 MscS_TM PF12794.7 ETO17111.1 - 0.11 11.4 3.5 0.044 12.6 0.3 1.9 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Ac76 PF05814.11 ETO17111.1 - 0.74 9.9 9.6 8.9 6.4 0.1 3.7 3 0 0 3 3 3 0 Orf76 (Ac76) TssO PF17561.2 ETO17111.1 - 3.8 7.6 14.6 0.17 12.0 1.6 3.3 3 0 0 3 3 3 0 Type VI secretion system, TssO HECT PF00632.25 ETO17114.1 - 9.7e-84 281.4 0.0 9.7e-84 281.4 0.0 1.8 2 1 0 2 2 2 1 HECT-domain (ubiquitin-transferase) RCC1 PF00415.18 ETO17114.1 - 3.4e-12 46.8 2.9 0.00019 22.0 0.1 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO17114.1 - 5.9e-09 35.5 5.8 4.4e-06 26.3 2.0 2.7 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat SgrT PF15894.5 ETO17114.1 - 0.15 12.1 0.6 0.35 10.9 0.6 1.5 1 0 0 1 1 1 0 Inhibitor of glucose uptake transporter SgrT HCO3_cotransp PF00955.21 ETO17114.1 - 1.6 7.5 6.3 3.4 6.4 6.3 1.5 1 0 0 1 1 1 0 HCO3- transporter family FAM76 PF16046.5 ETO17114.1 - 3.9 6.7 13.3 0.91 8.8 2.8 2.2 2 0 0 2 2 2 0 FAM76 protein RCC1_2 PF13540.6 ETO17115.1 - 4.7e-08 32.6 0.7 0.0032 17.2 0.0 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO17115.1 - 5.9e-08 33.2 3.0 9.2e-06 26.2 0.1 2.7 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat DUF4749 PF15936.5 ETO17115.1 - 0.37 11.9 4.5 0.18 12.9 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4749) adh_short PF00106.25 ETO17116.1 - 4.1e-31 108.0 0.0 4e-30 104.7 0.0 2.0 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO17116.1 - 1.7e-16 60.5 0.0 4.4e-15 55.9 0.0 2.0 1 1 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 ETO17116.1 - 0.043 13.6 0.3 0.36 10.6 0.0 2.1 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase KR PF08659.10 ETO17116.1 - 0.074 12.9 0.0 0.14 12.0 0.0 1.4 1 0 0 1 1 1 0 KR domain OAD_gamma PF04277.13 ETO17116.1 - 0.15 12.7 1.0 0.33 11.6 1.0 1.6 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain UCH PF00443.29 ETO17117.1 - 7.1e-28 97.8 0.3 7.1e-28 97.8 0.3 2.0 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO17117.1 - 1.5e-13 51.1 0.4 1.5e-13 51.1 0.4 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PTPRCAP PF15713.5 ETO17117.1 - 0.026 14.8 0.2 0.23 11.8 0.0 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Cullin_binding PF03556.15 ETO17119.1 - 0.06 13.8 0.1 0.13 12.7 0.1 1.5 1 0 0 1 1 1 0 Cullin binding DUF1911 PF08929.10 ETO17119.1 - 0.31 11.8 0.2 0.31 11.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1911) NUT PF12881.7 ETO17120.1 - 0.19 10.1 9.4 0.25 9.7 9.4 1.2 1 0 0 1 1 1 0 NUT protein FYDLN_acid PF09538.10 ETO17120.1 - 0.25 12.0 15.2 0.2 12.3 8.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) Serinc PF03348.15 ETO17120.1 - 2.9 6.7 11.0 0.36 9.7 6.0 1.8 2 0 0 2 2 2 0 Serine incorporator (Serinc) Dicty_REP PF05086.12 ETO17120.1 - 4.5 5.1 9.0 6.3 4.6 9.0 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Nucleo_P87 PF07267.11 ETO17120.1 - 4.6 6.0 8.7 5.3 5.8 8.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TraG_N PF07916.11 ETO17120.1 - 5.7 5.7 8.4 7.9 5.2 8.4 1.1 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Mvb12 PF09452.10 ETO17122.1 - 0.12 12.8 1.5 0.94 9.9 0.2 2.2 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 Sec20 PF03908.13 ETO17122.1 - 0.57 10.1 0.0 0.57 10.1 0.0 3.0 4 0 0 4 4 4 0 Sec20 DUF5102 PF17104.5 ETO17122.1 - 0.66 10.0 3.5 2.3 8.2 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5102) RGS PF00615.19 ETO17124.1 - 2e-06 28.0 0.7 2.8e-06 27.6 0.7 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain ATG19_autophagy PF12744.7 ETO17124.1 - 0.07 12.3 0.8 0.085 12.0 0.8 1.3 1 0 0 1 1 1 0 Autophagy protein Atg19, Atg8-binding TPR_2 PF07719.17 ETO17125.1 - 2.2e-13 49.2 21.1 0.0024 17.9 0.0 6.9 8 0 0 8 8 7 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17125.1 - 2.8e-11 42.7 22.8 0.0011 18.7 0.9 6.2 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17125.1 - 5.2e-11 41.8 15.9 0.0083 16.3 0.3 6.3 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17125.1 - 2.6e-08 33.4 5.3 0.016 14.9 0.1 5.6 5 1 1 6 6 6 2 TPR repeat TPR_14 PF13428.6 ETO17125.1 - 1.3e-07 31.8 0.3 0.058 14.2 0.0 5.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17125.1 - 3.7e-07 30.3 0.1 0.28 11.5 0.0 4.6 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17125.1 - 2.9e-06 27.8 0.0 4.7 8.0 0.0 5.0 6 0 0 6 6 5 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17125.1 - 6.3e-06 26.3 8.9 0.17 12.1 0.2 4.5 4 1 0 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO17125.1 - 5.7e-05 23.5 1.2 0.85 10.2 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17125.1 - 0.0071 16.3 4.5 2.4 8.4 0.1 4.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17125.1 - 0.012 16.2 3.2 16 6.4 0.0 4.9 6 0 0 6 6 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17125.1 - 0.021 15.2 9.7 0.068 13.6 0.2 5.2 6 1 0 6 6 5 0 Tetratricopeptide repeat Rad21_Rec8_N PF04825.13 ETO17125.1 - 0.032 14.4 0.0 0.075 13.2 0.0 1.6 1 0 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein TPR_9 PF13371.6 ETO17125.1 - 0.04 14.1 0.0 21 5.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO17125.1 - 0.11 12.6 2.2 16 5.7 0.1 3.4 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat Sigma70_ner PF04546.13 ETO17125.1 - 0.11 12.3 8.6 0.53 10.1 5.7 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.14 ETO17125.1 - 0.11 10.7 5.9 0.16 10.2 5.9 1.2 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETO17125.1 - 0.24 11.0 4.7 0.44 10.2 4.7 1.4 1 0 0 1 1 1 0 FAM176 family DNA_pol_phi PF04931.13 ETO17125.1 - 0.36 8.9 11.6 0.5 8.4 11.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF3245 PF11595.8 ETO17125.1 - 1.7 9.1 10.3 0.66 10.4 7.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DUF4175 PF13779.6 ETO17125.1 - 1.8 6.3 9.3 2.6 5.9 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) WD40 PF00400.32 ETO17126.1 - 8.5e-142 456.8 62.0 5.4e-10 39.7 0.2 15.2 15 0 0 15 15 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17126.1 - 2e-57 191.5 14.2 4.5e-05 23.7 0.0 14.6 1 1 13 14 14 14 14 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO17126.1 - 9.6e-28 97.4 3.8 3.3e-06 26.7 0.0 8.3 1 1 10 11 11 11 10 WD40-like domain Ge1_WD40 PF16529.5 ETO17126.1 - 1.8e-22 79.8 10.3 0.097 11.6 0.0 13.6 1 1 13 14 14 14 8 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO17126.1 - 3.1e-11 42.9 10.4 23 5.0 0.0 12.3 13 0 0 13 13 13 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 ETO17126.1 - 1.3e-09 38.1 0.0 3.6e-09 36.8 0.0 1.7 2 0 0 2 2 2 1 NACHT domain DUF727 PF05303.12 ETO17126.1 - 1.9e-06 27.8 2.3 15 5.7 0.0 10.1 1 1 13 14 14 14 0 Protein of unknown function (DUF727) Cytochrom_D1 PF02239.16 ETO17126.1 - 5.8e-05 21.8 13.0 0.47 8.9 0.5 5.3 1 1 2 5 5 5 3 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO17126.1 - 0.00011 21.7 0.3 0.00027 20.5 0.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO17126.1 - 0.017 15.7 0.3 0.13 12.8 0.0 2.8 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO17126.1 - 0.022 15.0 0.1 0.11 12.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO17126.1 - 0.034 14.6 0.2 0.41 11.2 0.0 2.8 2 0 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 ETO17126.1 - 0.058 13.3 0.2 0.57 10.1 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase CbiA PF01656.23 ETO17126.1 - 0.092 12.8 0.5 19 5.4 0.0 2.9 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain CDC45 PF02724.14 ETO17127.1 - 3.3 5.9 32.3 3.5 5.8 32.3 1.0 1 0 0 1 1 1 0 CDC45-like protein HALZ PF02183.18 ETO17128.1 - 0.00043 20.5 0.7 0.0012 19.0 0.7 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper DivIC PF04977.15 ETO17128.1 - 5.5 6.8 10.1 1.8 8.4 1.3 2.7 2 0 0 2 2 2 0 Septum formation initiator UPF0262 PF06793.12 ETO17129.1 - 0.064 13.4 0.7 0.12 12.5 0.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0262) zf-RING_2 PF13639.6 ETO17130.1 - 0.00017 21.9 9.1 0.00037 20.8 9.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING-like PF08746.11 ETO17130.1 - 0.0019 18.5 9.3 0.0019 18.5 9.3 1.8 2 0 0 2 2 2 1 RING-like domain Zn_ribbon_17 PF17120.5 ETO17130.1 - 0.037 13.6 12.5 0.21 11.2 10.8 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type DsbG_N PF18257.1 ETO17130.1 - 0.2 11.8 1.7 0.73 10.0 0.3 2.5 3 0 0 3 3 3 0 Disulfide isomerase DsbG N-terminal PHD PF00628.29 ETO17130.1 - 0.25 11.3 8.7 0.61 10.0 8.7 1.7 1 0 0 1 1 1 0 PHD-finger C1_2 PF03107.16 ETO17130.1 - 0.5 10.7 10.3 0.11 12.8 6.1 2.1 2 0 0 2 2 2 0 C1 domain zf-HC5HC2H PF13771.6 ETO17130.1 - 2.6 8.4 14.3 0.2 11.9 8.3 2.2 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ETO17130.1 - 3.6 7.8 11.7 1.1 9.5 7.1 2.2 2 0 0 2 2 2 0 PHD-zinc-finger like domain Methyltrans_RNA PF04452.14 ETO17131.1 - 9.2e-31 106.9 0.0 5.2e-30 104.5 0.0 2.1 2 1 0 2 2 2 1 RNA methyltransferase RGS PF00615.19 ETO17132.1 - 0.011 16.0 4.0 1 9.6 0.2 2.6 2 0 0 2 2 2 0 Regulator of G protein signaling domain YflT PF11181.8 ETO17132.1 - 0.096 13.2 0.4 0.54 10.8 0.0 2.2 2 1 0 2 2 2 0 Heat induced stress protein YflT Glyco_hydro_53 PF07745.13 ETO17134.1 - 5.6e-13 48.6 0.1 7.2e-13 48.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Coatomer_WDAD PF04053.14 ETO17135.1 - 4.4e-25 88.6 0.1 3.5e-24 85.7 0.0 2.1 2 1 1 3 3 3 1 Coatomer WD associated region WD40 PF00400.32 ETO17135.1 - 1.6e-20 73.0 3.7 4.8e-06 27.2 0.0 5.3 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17135.1 - 0.067 13.5 0.0 1.9 8.8 0.0 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain Connexin PF00029.19 ETO17137.1 - 0.006 16.4 0.8 0.0074 16.1 0.8 1.1 1 0 0 1 1 1 1 Connexin ATP-synt_E PF05680.12 ETO17137.1 - 0.023 15.0 5.6 0.034 14.5 5.6 1.2 1 0 0 1 1 1 0 ATP synthase E chain RPN2_C PF18004.1 ETO17137.1 - 0.055 13.4 9.8 0.075 13.0 9.8 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain GWT1 PF06423.12 ETO17137.1 - 0.094 12.8 0.2 0.16 12.1 0.1 1.4 1 1 0 1 1 1 0 GWT1 Folate_carrier PF01770.18 ETO17137.1 - 0.096 11.4 0.8 0.12 11.0 0.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier OATP PF03137.20 ETO17137.1 - 0.2 9.9 2.1 0.25 9.6 2.1 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family MAP17 PF15807.5 ETO17137.1 - 0.54 10.5 6.0 0.8 10.0 6.0 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Ureide_permease PF07168.11 ETO17137.1 - 0.67 8.6 2.2 0.78 8.4 2.2 1.1 1 0 0 1 1 1 0 Ureide permease Sec62 PF03839.16 ETO17137.1 - 1.7 8.1 9.6 2.6 7.5 9.6 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3464 PF11947.8 ETO17137.1 - 3 7.6 5.3 4.2 7.1 5.3 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Nop25 PF09805.9 ETO17138.1 - 0.0079 16.7 0.5 0.0093 16.4 0.5 1.1 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) AP3D1 PF06375.11 ETO17138.1 - 0.017 15.4 1.7 0.021 15.0 1.7 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 mTERF PF02536.14 ETO17141.1 - 7.5e-05 21.8 9.1 0.0032 16.5 0.3 2.9 1 1 2 3 3 3 3 mTERF 7tm_1 PF00001.21 ETO17143.1 - 8.5e-05 22.0 3.7 8.5e-05 22.0 3.7 2.5 3 1 1 4 4 4 1 7 transmembrane receptor (rhodopsin family) DUF5400 PF17379.2 ETO17143.1 - 0.12 12.9 4.2 1.8 9.1 0.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5400) LprI PF07007.12 ETO17144.1 - 0.0065 17.1 6.6 0.019 15.6 6.6 1.8 1 0 0 1 1 1 1 Lysozyme inhibitor LprI SIMPL PF04402.14 ETO17144.1 - 0.016 15.7 1.5 0.039 14.4 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF541) DUF4407 PF14362.6 ETO17144.1 - 0.11 11.8 7.0 0.2 11.0 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tyrosinase PF00264.20 ETO17144.1 - 0.56 10.4 7.0 1.2 9.4 6.6 1.8 1 1 0 1 1 1 0 Common central domain of tyrosinase RcpC PF16976.5 ETO17144.1 - 0.63 10.1 2.9 1.9 8.6 2.9 1.7 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB PSI_PsaF PF02507.15 ETO17144.1 - 1.1 9.0 6.8 0.9 9.4 3.8 2.3 2 1 1 3 3 3 0 Photosystem I reaction centre subunit III CAP_GLY PF01302.25 ETO17145.1 - 0.00026 20.9 0.4 0.00082 19.3 0.1 2.1 2 0 0 2 2 2 1 CAP-Gly domain JTB PF05439.12 ETO17146.1 - 0.031 14.3 1.3 0.066 13.3 1.3 1.6 1 0 0 1 1 1 0 Jumping translocation breakpoint protein (JTB) Gly-zipper_Omp PF13488.6 ETO17147.1 - 0.84 9.7 6.3 5.8 7.0 6.3 2.2 1 1 0 1 1 1 0 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO17147.1 - 5.3 6.9 6.3 0.63 9.8 0.3 1.8 1 1 1 2 2 2 0 YMGG-like Gly-zipper CDC37_N PF03234.14 ETO17149.1 - 1.4 9.9 7.2 14 6.6 0.3 2.5 2 0 0 2 2 2 0 Cdc37 N terminal kinase binding DUF3915 PF13054.6 ETO17150.1 - 0.046 13.7 3.0 0.11 12.5 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) GrpE PF01025.19 ETO17150.1 - 0.29 10.8 6.9 1.3 8.7 0.2 2.6 1 1 1 2 2 2 0 GrpE Orf78 PF06024.12 ETO17150.1 - 3.9 7.8 12.1 8.4 6.8 1.8 2.9 2 0 0 2 2 2 0 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO17150.1 - 7.2 7.2 15.0 0.82 10.3 9.9 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain FAM76 PF16046.5 ETO17151.1 - 7.9 5.7 7.7 1.1 8.5 1.9 2.0 2 0 0 2 2 2 0 FAM76 protein ESM4 PF15952.5 ETO17152.1 - 6.7 7.1 9.5 11 6.4 9.5 1.3 1 0 0 1 1 1 0 Enhancer of split M4 family Ras PF00071.22 ETO17153.1 - 1e-29 103.2 0.2 7.4e-28 97.2 0.2 2.0 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO17153.1 - 4.7e-10 39.7 0.1 1.1e-08 35.3 0.1 2.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase PH PF00169.29 ETO17154.1 - 5.5e-15 55.8 1.2 4.7e-14 52.8 1.2 2.4 1 1 0 1 1 1 1 PH domain PH_9 PF15410.6 ETO17154.1 - 0.00029 21.2 0.5 0.028 14.8 0.0 3.0 3 0 0 3 3 3 1 Pleckstrin homology domain zf-RING_UBOX PF13445.6 ETO17155.1 - 0.00018 21.5 10.1 0.00018 21.5 10.1 2.1 2 0 0 2 2 2 1 RING-type zinc-finger NOA36 PF06524.12 ETO17155.1 - 0.0024 17.2 6.7 0.0057 16.0 0.2 2.5 3 0 0 3 3 3 2 NOA36 protein zf-RING_2 PF13639.6 ETO17155.1 - 0.024 15.0 14.7 0.15 12.4 11.3 2.4 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 ETO17155.1 - 0.027 14.4 13.4 0.026 14.4 9.8 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO17155.1 - 0.067 13.2 14.3 0.2 11.6 14.3 1.9 1 1 0 1 1 1 0 zinc-RING finger domain zf-RING_6 PF14835.6 ETO17155.1 - 0.25 11.2 4.0 0.61 10.0 4.0 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_2 PF13923.6 ETO17155.1 - 0.87 9.5 16.6 0.17 11.7 11.4 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO17155.1 - 7.1 6.6 14.9 10 6.1 10.7 2.4 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 WD40 PF00400.32 ETO17157.1 - 4.9e-41 137.9 6.2 1.1e-09 38.7 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17157.1 - 3.5e-13 49.6 0.2 0.0038 17.5 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17157.1 - 9.3e-07 28.1 0.1 0.65 8.9 0.0 3.6 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO17157.1 - 7.1e-06 25.8 0.3 6 6.9 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO17157.1 - 0.00032 20.1 0.1 0.0035 16.7 0.0 1.9 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO17157.1 - 0.00057 18.6 4.8 1.9 7.1 0.4 4.1 1 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO17157.1 - 0.0048 17.0 2.4 5.5 7.1 0.0 3.9 1 1 2 4 4 4 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO17157.1 - 0.0081 15.5 0.1 0.27 10.5 0.0 2.5 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal DUF4072 PF13284.6 ETO17157.1 - 0.014 15.8 0.0 45 4.6 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4072) Cytochrom_D1 PF02239.16 ETO17157.1 - 0.072 11.6 0.1 0.91 8.0 0.0 2.1 1 1 1 2 2 2 0 Cytochrome D1 heme domain DUF1652 PF07865.11 ETO17157.1 - 0.098 12.5 0.3 25 4.8 0.0 3.7 2 1 1 4 4 4 0 Protein of unknown function (DUF1652) DPPIV_N PF00930.21 ETO17157.1 - 0.17 10.6 0.0 3.8 6.2 0.0 2.9 1 1 0 1 1 1 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF4083 PF13314.6 ETO17158.1 - 0.13 12.2 0.4 0.13 12.2 0.4 3.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4083) DUF2973 PF11189.8 ETO17158.1 - 0.18 11.9 3.4 0.5 10.5 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) DUF4307 PF14155.6 ETO17158.1 - 0.96 9.3 2.9 6 6.7 0.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4307) Pox_A14 PF05767.12 ETO17158.1 - 1.1 9.5 9.8 1.1 9.5 2.9 2.4 2 0 0 2 2 2 0 Poxvirus virion envelope protein A14 PH PF00169.29 ETO17159.1 - 6.7 7.3 14.0 62 4.2 8.7 3.3 2 1 0 2 2 2 0 PH domain MIP PF00230.20 ETO17163.1 - 1.2e-10 41.5 5.9 1.8e-09 37.6 5.9 2.0 1 1 0 1 1 1 1 Major intrinsic protein Sugar_transport PF06800.12 ETO17163.1 - 0.0031 16.9 0.2 0.004 16.5 0.2 1.2 1 0 0 1 1 1 1 Sugar transport protein DUF2951 PF11166.8 ETO17163.1 - 0.12 12.6 0.1 0.46 10.7 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) DUF1340 PF07067.11 ETO17164.1 - 0.016 14.6 0.1 0.2 11.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1340) Hemerythrin PF01814.23 ETO17166.1 - 0.00039 21.0 0.4 0.0032 18.1 0.4 2.1 1 1 0 1 1 1 1 Hemerythrin HHE cation binding domain zf-TRAF PF02176.18 ETO17167.1 - 0.079 13.7 0.8 0.079 13.7 0.8 2.4 2 0 0 2 2 2 0 TRAF-type zinc finger ShK PF01549.24 ETO17167.1 - 0.15 12.6 7.2 0.44 11.1 0.6 2.5 2 0 0 2 2 2 0 ShK domain-like V_ATPase_I PF01496.19 ETO17168.1 - 0.002 16.2 2.1 0.002 16.2 2.1 2.0 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family LrgA PF03788.14 ETO17168.1 - 0.21 11.5 4.0 0.3 11.1 4.0 1.1 1 0 0 1 1 1 0 LrgA family CCDC71L PF15374.6 ETO17168.1 - 0.33 10.2 15.5 0.42 9.8 15.5 1.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L WTF PF03303.13 ETO17168.1 - 0.98 9.1 12.7 0.29 10.8 9.7 1.5 1 1 1 2 2 2 0 WTF protein Hid1 PF12722.7 ETO17168.1 - 4.7 5.2 18.3 6.2 4.8 18.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 ETO17168.1 - 5.1 5.4 11.0 8.9 4.6 10.9 1.6 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Myco_arth_vir_N PF09610.10 ETO17168.1 - 5.3 7.2 7.6 13 6.0 7.6 1.6 1 1 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Rad51 PF08423.11 ETO17170.1 - 6e-05 22.4 0.1 0.00011 21.5 0.0 1.4 2 0 0 2 2 2 1 Rad51 Adenyl_transf PF04439.12 ETO17170.1 - 0.011 14.8 0.1 0.015 14.4 0.1 1.3 1 0 0 1 1 1 0 Streptomycin adenylyltransferase PUB PF09409.10 ETO17171.1 - 0.029 14.3 0.8 0.21 11.6 0.8 2.1 1 1 0 1 1 1 0 PUB domain Ferlin_C PF16165.5 ETO17171.1 - 0.068 13.1 0.5 0.11 12.5 0.5 1.3 1 0 0 1 1 1 0 Ferlin C-terminus YL1 PF05764.13 ETO17172.1 - 0.00042 20.5 16.4 0.00049 20.3 16.4 1.0 1 0 0 1 1 1 1 YL1 nuclear protein Zip PF02535.22 ETO17172.1 - 0.00064 19.0 1.7 0.00077 18.8 1.7 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4834 PF16118.5 ETO17172.1 - 0.0022 18.9 7.4 0.012 16.6 7.4 2.0 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) DUF4820 PF16091.5 ETO17172.1 - 0.0093 15.4 6.6 0.012 15.0 6.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4820) DUF2052 PF09747.9 ETO17172.1 - 0.012 15.7 21.1 0.015 15.4 21.1 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) DDHD PF02862.17 ETO17172.1 - 0.014 15.6 3.5 0.017 15.3 3.5 1.3 1 0 0 1 1 1 0 DDHD domain AUX_IAA PF02309.16 ETO17172.1 - 0.017 15.0 3.3 0.02 14.8 3.3 1.2 1 0 0 1 1 1 0 AUX/IAA family Pex14_N PF04695.13 ETO17172.1 - 0.03 15.0 9.7 0.046 14.4 9.7 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CDC45 PF02724.14 ETO17172.1 - 0.045 12.0 16.3 0.057 11.7 16.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO17172.1 - 0.046 14.0 15.8 0.054 13.8 15.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SpoIIP PF07454.11 ETO17172.1 - 0.13 11.7 12.2 0.17 11.3 12.2 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) TFIIF_alpha PF05793.12 ETO17172.1 - 0.13 10.8 19.3 0.16 10.5 19.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sec62 PF03839.16 ETO17172.1 - 0.14 11.7 7.5 0.18 11.3 7.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 PI3K_1B_p101 PF10486.9 ETO17172.1 - 0.19 9.5 5.6 0.2 9.4 5.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Endostatin PF06482.11 ETO17172.1 - 0.21 11.0 5.3 0.24 10.8 5.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin FancD2 PF14631.6 ETO17172.1 - 0.38 8.1 5.9 0.44 7.9 5.9 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RR_TM4-6 PF06459.12 ETO17172.1 - 0.43 10.3 18.8 0.52 10.1 18.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Merozoite_SPAM PF07133.11 ETO17172.1 - 0.45 10.5 28.4 0.57 10.2 28.4 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Presenilin PF01080.17 ETO17172.1 - 0.54 9.0 15.7 0.67 8.7 15.7 1.1 1 0 0 1 1 1 0 Presenilin NARP1 PF12569.8 ETO17172.1 - 0.59 9.0 13.9 0.71 8.7 13.9 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SLC12 PF03522.15 ETO17172.1 - 0.62 9.0 13.2 0.75 8.8 13.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 ETO17172.1 - 0.68 8.7 12.1 0.81 8.4 12.1 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SID-1_RNA_chan PF13965.6 ETO17172.1 - 0.79 8.1 3.6 0.83 8.0 3.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Neur_chan_memb PF02932.16 ETO17172.1 - 0.87 9.6 3.9 1.1 9.3 3.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CNDH2_M PF16869.5 ETO17172.1 - 0.89 10.2 9.9 1.2 9.8 9.9 1.1 1 0 0 1 1 1 0 PF16858 Lin-8 PF03353.15 ETO17172.1 - 0.93 9.0 16.2 1.1 8.7 16.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist CPSF100_C PF13299.6 ETO17172.1 - 0.96 9.6 12.2 1.4 9.1 12.2 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ndc1_Nup PF09531.10 ETO17172.1 - 1 8.0 9.2 1.3 7.7 9.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup GREB1 PF15782.5 ETO17172.1 - 1 6.4 6.5 1.1 6.2 6.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF913 PF06025.12 ETO17172.1 - 1.5 7.7 9.3 1.8 7.5 9.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.12 ETO17172.1 - 1.6 6.8 20.6 1.9 6.6 20.6 1.0 1 0 0 1 1 1 0 Nop14-like family GAGA_bind PF06217.12 ETO17172.1 - 2 8.6 10.8 2.4 8.3 10.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Rtf2 PF04641.12 ETO17172.1 - 2.1 7.7 14.9 2.5 7.4 14.9 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Sporozoite_P67 PF05642.11 ETO17172.1 - 2.4 6.1 13.1 2.7 6.0 13.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Cytomega_UL84 PF06284.11 ETO17172.1 - 2.7 6.3 9.3 3.2 6.1 9.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Tim54 PF11711.8 ETO17172.1 - 3.1 6.5 16.1 3.9 6.2 16.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Membralin PF09746.9 ETO17172.1 - 3.8 6.5 5.8 4.4 6.2 5.8 1.2 1 0 0 1 1 1 0 Tumour-associated protein PPL5 PF18168.1 ETO17172.1 - 4.6 6.4 10.5 6.2 6.0 10.5 1.2 1 0 0 1 1 1 0 Prim-pol family 5 FAM60A PF15396.6 ETO17172.1 - 6.3 6.7 10.4 8.1 6.4 10.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A LAP1C PF05609.12 ETO17172.1 - 6.8 5.7 17.1 8.5 5.4 17.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF4770 PF15994.5 ETO17172.1 - 7.7 6.7 10.7 13 6.0 10.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Hid1 PF12722.7 ETO17172.1 - 8 4.4 15.9 9.5 4.2 15.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DNA_pol_phi PF04931.13 ETO17172.1 - 8.4 4.4 16.7 9.6 4.2 16.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Peptidase_S49_N PF08496.10 ETO17172.1 - 9.5 6.3 10.2 16 5.5 10.2 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Mito_fiss_reg PF05308.11 ETO17174.1 - 0.0045 17.1 3.9 0.0045 17.1 3.9 2.6 2 0 0 2 2 2 2 Mitochondrial fission regulator RRM_1 PF00076.22 ETO17175.1 - 1.1e-09 37.9 0.0 2.8e-09 36.6 0.0 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) TPR_2 PF07719.17 ETO17176.1 - 0.012 15.6 2.2 1.3 9.3 0.3 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17176.1 - 0.029 14.2 1.8 4.4 7.3 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat Phage_Gp23 PF10669.9 ETO17176.1 - 0.032 14.6 1.1 0.047 14.0 1.1 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Zip PF02535.22 ETO17176.1 - 0.32 10.2 0.7 0.41 9.8 0.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter G-alpha PF00503.20 ETO17177.1 - 1e-109 367.0 7.5 1.4e-109 366.6 7.5 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO17177.1 - 1.7e-10 40.6 0.3 1.8e-07 30.8 0.0 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO17177.1 - 0.00081 18.8 2.6 0.039 13.3 0.0 3.0 3 0 0 3 3 3 1 Gtr1/RagA G protein conserved region Roc PF08477.13 ETO17177.1 - 0.0015 18.8 0.1 0.84 9.9 0.0 2.6 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO17177.1 - 0.0061 16.6 0.0 3.9 7.6 0.0 2.6 2 0 0 2 2 2 2 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO17177.1 - 0.0089 15.6 0.1 1.8 8.1 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain TniB PF05621.11 ETO17177.1 - 0.016 14.6 0.1 0.032 13.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein FtsK_SpoIIIE PF01580.18 ETO17177.1 - 0.055 12.8 0.1 0.12 11.7 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 ETO17177.1 - 0.062 13.1 0.1 0.15 11.8 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain CRS1_YhbY PF01985.21 ETO17177.1 - 0.092 12.9 0.6 0.35 11.1 0.3 2.1 1 1 1 2 2 2 0 CRS1 / YhbY (CRM) domain RabGAP-TBC PF00566.18 ETO17178.1 - 3.4e-38 131.5 4.7 3.4e-38 131.5 4.7 2.9 2 1 0 2 2 2 1 Rab-GTPase-TBC domain CDC45 PF02724.14 ETO17178.1 - 0.0051 15.2 10.2 0.007 14.7 10.2 1.1 1 0 0 1 1 1 1 CDC45-like protein PTPRCAP PF15713.5 ETO17178.1 - 0.08 13.2 14.6 0.15 12.4 14.6 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated LCD1 PF09798.9 ETO17178.1 - 0.28 9.7 9.1 0.5 8.8 9.1 1.3 1 0 0 1 1 1 0 DNA damage checkpoint protein Cytomega_UL84 PF06284.11 ETO17178.1 - 0.58 8.5 6.0 0.86 8.0 6.0 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Sec62 PF03839.16 ETO17178.1 - 0.96 8.9 11.8 1.9 7.9 11.8 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 ETO17178.1 - 1.4 8.0 3.3 2.2 7.4 3.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter BRICHOS PF04089.14 ETO17179.1 - 0.023 14.9 0.2 0.041 14.1 0.2 1.3 1 0 0 1 1 1 0 BRICHOS domain Head_binding PF09008.10 ETO17179.1 - 0.044 14.0 0.2 0.073 13.3 0.2 1.3 1 0 0 1 1 1 0 Head binding TYA PF01021.19 ETO17179.1 - 0.057 13.7 0.6 0.057 13.7 0.6 1.7 2 0 0 2 2 2 0 TYA transposon protein SAM_1 PF00536.30 ETO17180.1 - 2.4e-11 43.9 1.4 3.7e-11 43.3 0.4 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO17180.1 - 1.9e-09 37.5 0.9 5.9e-09 35.9 0.2 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Mito_fiss_reg PF05308.11 ETO17180.1 - 0.034 14.2 0.4 0.041 14.0 0.4 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator BCAS2 PF05700.11 ETO17180.1 - 0.15 11.8 3.5 0.25 11.0 3.5 1.4 1 0 0 1 1 1 0 Breast carcinoma amplified sequence 2 (BCAS2) Lipase_chap PF03280.14 ETO17180.1 - 0.15 12.0 5.3 0.25 11.3 5.3 1.3 1 0 0 1 1 1 0 Proteobacterial lipase chaperone protein UPF0449 PF15136.6 ETO17180.1 - 1 9.8 6.6 2.7 8.5 6.6 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 DHR10 PF18595.1 ETO17180.1 - 1.8 8.6 13.7 0.48 10.5 6.9 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Spc7 PF08317.11 ETO17180.1 - 6.6 5.5 11.9 0.57 9.0 7.2 1.5 2 0 0 2 2 2 0 Spc7 kinetochore protein PHR PF08005.12 ETO17181.1 - 0.045 14.4 0.2 0.073 13.7 0.2 1.4 1 0 0 1 1 1 0 PHR domain TPR_1 PF00515.28 ETO17182.1 - 3e-16 58.5 2.9 8.5e-07 28.5 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17182.1 - 3.1e-14 51.9 1.9 4.8e-06 26.3 0.0 3.8 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17182.1 - 4.5e-09 35.8 0.6 0.0023 18.0 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17182.1 - 7.2e-06 26.4 0.0 0.082 13.4 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17182.1 - 1.9e-05 25.0 0.0 0.027 15.1 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17182.1 - 0.00024 20.7 6.8 0.22 11.2 0.1 4.1 2 2 3 5 5 5 2 TPR repeat TPR_14 PF13428.6 ETO17182.1 - 0.00072 20.2 0.0 1.9 9.5 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17182.1 - 0.00076 20.1 0.0 0.94 10.2 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO17182.1 - 0.00082 19.4 4.3 0.052 13.6 0.1 3.2 3 1 1 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_9 PF13371.6 ETO17182.1 - 0.0015 18.6 0.0 0.0061 16.7 0.0 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17182.1 - 0.0027 17.9 1.1 0.017 15.3 0.8 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ETO17182.1 - 0.0041 17.4 2.1 0.087 13.2 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17182.1 - 0.031 14.6 2.5 0.34 11.2 0.2 3.3 2 2 1 3 3 3 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ETO17182.1 - 0.037 14.0 2.2 0.089 12.8 1.7 1.8 1 1 0 1 1 1 0 Putative TPR-like repeat TPR_3 PF07720.12 ETO17182.1 - 2 8.5 4.4 1.8 8.6 0.1 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat PBP1_TM PF14812.6 ETO17182.1 - 9.3 6.7 8.4 10 6.6 5.0 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal AIF_C PF14721.6 ETO17183.1 - 0.12 12.7 6.6 0.16 12.4 6.6 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF2058 PF09831.9 ETO17183.1 - 0.43 10.7 12.6 0.44 10.7 12.6 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) CDC45 PF02724.14 ETO17183.1 - 0.44 8.8 7.5 0.4 8.9 7.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO17183.1 - 1.1 9.0 8.2 1.2 8.9 8.2 1.1 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 ETO17183.1 - 1.5 8.6 9.1 1.6 8.4 9.1 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Zip PF02535.22 ETO17183.1 - 1.6 7.9 2.5 1.6 7.9 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO17183.1 - 2 7.1 5.4 2 7.1 5.4 1.0 1 0 0 1 1 1 0 Presenilin DUF4890 PF16231.5 ETO17183.1 - 2.3 8.7 17.4 3.1 8.3 17.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4890) Peptidase_S49_N PF08496.10 ETO17183.1 - 2.3 8.2 13.4 2.8 8.0 13.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal HNOBA PF07701.14 ETO17183.1 - 3 7.2 9.4 3.7 6.9 9.4 1.1 1 0 0 1 1 1 0 Heme NO binding associated RR_TM4-6 PF06459.12 ETO17183.1 - 3.2 7.5 12.6 3.4 7.4 12.6 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 ETO17183.1 - 4.1 6.9 10.5 4.2 6.8 10.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 NYD-SP12_N PF15015.6 ETO17183.1 - 4.3 5.6 12.1 4.5 5.5 12.1 1.0 1 0 0 1 1 1 0 Spermatogenesis-associated, N-terminal EOS1 PF12326.8 ETO17183.1 - 4.8 7.1 4.8 5.3 6.9 4.8 1.1 1 0 0 1 1 1 0 N-glycosylation protein Vps4_C PF09336.10 ETO17184.1 - 2.2e-22 78.8 0.0 2.1e-21 75.7 0.0 2.0 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ETO17184.1 - 0.005 16.6 0.0 0.016 15.0 0.0 1.9 2 0 0 2 2 2 1 AAA+ lid domain Kelch_1 PF01344.25 ETO17185.1 - 7.3e-05 22.3 1.9 0.00053 19.5 0.6 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO17185.1 - 0.0028 17.6 0.4 0.038 14.0 0.3 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO17185.1 - 0.0047 16.9 0.5 0.018 15.1 0.6 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO17185.1 - 0.012 15.6 0.2 0.6 10.2 0.1 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO17185.1 - 0.087 13.1 1.0 8.2 6.9 0.5 2.5 2 0 0 2 2 2 0 Kelch motif PHR PF08005.12 ETO17186.1 - 0.45 11.2 4.4 0.98 10.1 4.4 1.7 1 1 0 1 1 1 0 PHR domain Zap1_zf2 PF18217.1 ETO17186.1 - 0.69 10.0 6.2 0.32 11.0 3.5 1.9 2 0 0 2 2 2 0 Zap1 zinc finger 2 Kelch_5 PF13854.6 ETO17187.1 - 2.3e-06 27.5 0.4 2.3 8.3 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO17187.1 - 0.00024 20.9 0.8 0.45 10.6 0.1 4.3 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO17187.1 - 0.00069 19.8 0.1 2.4 8.6 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO17187.1 - 0.00084 19.3 0.2 1.7 8.7 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO17187.1 - 0.0026 17.3 1.8 0.61 9.7 0.1 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO17188.1 - 1.3e-08 34.8 1.3 0.0016 18.6 0.1 4.2 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO17188.1 - 4.4e-07 29.4 1.8 6.3e-05 22.5 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO17188.1 - 1.3e-05 25.4 0.1 0.00019 21.6 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO17188.1 - 2.6e-05 24.0 4.3 0.21 11.6 0.3 5.3 5 2 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO17188.1 - 0.00012 22.0 6.7 1.2 9.3 0.1 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 ETO17188.1 - 0.0002 21.3 0.2 0.052 13.6 0.2 3.3 2 1 0 2 2 2 1 Galactose oxidase, central domain NAD_synthase PF02540.17 ETO17189.1 - 1.6e-75 253.4 0.2 2.4e-75 252.8 0.2 1.2 1 0 0 1 1 1 1 NAD synthase CN_hydrolase PF00795.22 ETO17189.1 - 6.5e-22 78.1 0.0 8.8e-22 77.7 0.0 1.2 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase tRNA_Me_trans PF03054.16 ETO17189.1 - 0.00021 20.2 0.0 0.00035 19.5 0.0 1.3 1 0 0 1 1 1 1 tRNA methyl transferase QueC PF06508.13 ETO17189.1 - 0.0059 16.1 0.1 0.019 14.5 0.0 1.9 2 0 0 2 2 2 1 Queuosine biosynthesis protein QueC Asn_synthase PF00733.21 ETO17189.1 - 0.036 13.7 0.0 0.059 13.0 0.0 1.3 1 0 0 1 1 1 0 Asparagine synthase La PF05383.17 ETO17190.1 - 2.1e-05 24.4 0.2 6.1e-05 23.0 0.2 1.8 1 0 0 1 1 1 1 La domain Jnk-SapK_ap_N PF09744.9 ETO17190.1 - 0.016 15.4 6.3 0.023 14.9 6.3 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 ETO17190.1 - 0.063 13.1 5.4 0.089 12.6 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) RelA_SpoT PF04607.17 ETO17191.1 - 0.0013 18.9 1.2 0.0013 18.9 1.2 3.3 3 1 0 3 3 3 1 Region found in RelA / SpoT proteins DUF3846 PF12957.7 ETO17191.1 - 0.13 12.6 0.0 4.6 7.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3846) CUE PF02845.16 ETO17192.1 - 0.015 15.0 0.1 0.095 12.4 0.0 2.3 2 0 0 2 2 2 0 CUE domain ART PF01129.18 ETO17192.1 - 0.03 13.6 0.0 0.053 12.8 0.0 1.4 1 0 0 1 1 1 0 NAD:arginine ADP-ribosyltransferase TPR_12 PF13424.6 ETO17193.1 - 7.1e-28 96.7 3.2 3.2e-09 37.0 0.1 3.5 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17193.1 - 1.5e-21 75.6 3.0 1.6e-07 30.9 0.1 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17193.1 - 1.7e-16 59.2 31.2 2.1e-08 33.6 2.8 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17193.1 - 1.9e-13 49.4 30.6 4.4e-06 26.4 1.1 6.1 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17193.1 - 2.7e-12 45.8 5.3 0.00017 21.4 0.1 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17193.1 - 1.6e-10 40.3 24.2 6.5e-06 26.0 1.4 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17193.1 - 5.9e-09 35.7 6.6 0.012 15.9 0.1 4.4 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17193.1 - 2.7e-07 30.2 19.2 0.031 14.0 1.0 6.2 3 2 1 4 4 4 3 TPR repeat TPR_MalT PF17874.1 ETO17193.1 - 1.4e-05 24.7 0.0 2.5e-05 23.8 0.0 1.4 1 1 0 1 1 1 1 MalT-like TPR region TPR_16 PF13432.6 ETO17193.1 - 8.4e-05 23.1 1.1 0.12 13.0 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17193.1 - 0.00023 21.6 5.0 1.8 9.4 0.2 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17193.1 - 0.0036 17.5 3.4 0.75 10.1 0.1 3.1 3 0 0 3 3 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETO17193.1 - 0.0053 17.5 5.9 13 6.9 0.0 4.9 6 0 0 6 6 4 0 Tetratricopeptide repeat MIT PF04212.18 ETO17193.1 - 0.037 14.1 2.0 1.4 9.1 0.1 3.5 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TRAP_beta PF05753.14 ETO17193.1 - 0.069 12.5 1.0 0.15 11.4 0.2 1.9 2 0 0 2 2 2 0 Translocon-associated protein beta (TRAPB) OEP PF02321.18 ETO17193.1 - 0.17 11.7 0.2 0.17 11.7 0.2 2.5 3 0 0 3 3 3 0 Outer membrane efflux protein DUF2225 PF09986.9 ETO17193.1 - 0.66 9.7 11.8 0.62 9.7 1.9 2.8 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) Lebercilin PF15619.6 ETO17194.1 - 0.00026 20.7 44.4 0.00026 20.7 44.4 4.3 3 1 1 4 4 4 2 Ciliary protein causing Leber congenital amaurosis disease DUF812 PF05667.11 ETO17194.1 - 0.0014 17.6 36.2 0.0014 17.6 36.2 3.2 2 1 1 3 3 3 1 Protein of unknown function (DUF812) ATG16 PF08614.11 ETO17194.1 - 0.0054 17.0 28.2 0.0054 17.0 28.2 5.4 2 2 3 5 5 5 1 Autophagy protein 16 (ATG16) IFT57 PF10498.9 ETO17194.1 - 0.006 15.6 30.2 0.006 15.6 30.2 4.6 3 2 1 4 4 4 1 Intra-flagellar transport protein 57 Phage_int_SAM_2 PF12834.7 ETO17194.1 - 0.1 13.3 12.6 11 6.8 3.2 4.0 3 0 0 3 3 3 0 Phage integrase, N-terminal GAS PF13851.6 ETO17194.1 - 0.63 9.4 96.0 0.067 12.5 32.7 5.5 4 1 2 6 6 6 0 Growth-arrest specific micro-tubule binding HOOK PF05622.12 ETO17194.1 - 3.3 5.8 78.0 0.0037 15.5 39.8 3.5 2 1 1 3 3 3 0 HOOK protein MAAL_C PF07476.11 ETO17194.1 - 8.5 5.4 10.4 0.2 10.8 0.4 2.9 2 1 1 3 3 3 0 Methylaspartate ammonia-lyase C-terminus Mga PF05043.13 ETO17195.1 - 2.2 8.9 9.6 1.2 9.7 0.8 3.8 4 0 0 4 4 4 0 Mga helix-turn-helix domain Aida_N PF08910.10 ETO17195.1 - 3.2 8.2 11.6 0.66 10.4 0.4 4.3 3 1 1 4 4 4 0 Aida N-terminus DUF1664 PF07889.12 ETO17195.1 - 9.6 6.3 28.4 0.16 12.0 6.1 4.2 4 0 0 4 4 4 0 Protein of unknown function (DUF1664) DUF4200 PF13863.6 ETO17195.1 - 9.8 6.6 63.2 0.096 13.1 18.7 5.2 5 0 0 5 5 5 0 Domain of unknown function (DUF4200) GF_recep_IV PF14843.6 ETO17196.1 - 0.043 13.6 0.1 0.054 13.3 0.1 1.1 1 0 0 1 1 1 0 Growth factor receptor domain IV DUF1539 PF07560.11 ETO17197.1 - 0.0078 16.3 2.4 0.02 14.9 0.6 2.2 2 0 0 2 2 2 1 Domain of Unknown Function (DUF1539) DnaB_2 PF07261.11 ETO17197.1 - 0.065 13.0 2.1 0.11 12.2 0.4 2.2 2 0 0 2 2 2 0 Replication initiation and membrane attachment tRNA_NucTran2_2 PF13735.6 ETO17197.1 - 0.07 13.1 2.2 7.4 6.5 0.1 2.2 2 0 0 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative IpgD PF05925.12 ETO17197.1 - 0.094 11.3 2.9 0.06 11.9 1.3 1.4 2 0 0 2 2 2 0 Enterobacterial virulence protein IpgD SATase_N PF06426.14 ETO17197.1 - 0.11 12.8 0.0 0.23 11.9 0.0 1.4 1 0 0 1 1 1 0 Serine acetyltransferase, N-terminal P5-ATPase PF12409.8 ETO17197.1 - 0.12 12.4 2.8 0.18 11.9 0.4 2.3 2 1 1 3 3 3 0 P5-type ATPase cation transporter HSP70 PF00012.20 ETO17199.1 - 6.3e-05 21.4 0.0 0.00014 20.2 0.0 1.5 1 0 0 1 1 1 1 Hsp70 protein WD40 PF00400.32 ETO17200.1 - 6.5e-24 83.8 14.1 6.6e-07 29.9 0.3 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17200.1 - 2.8e-05 24.3 1.6 0.24 11.7 0.1 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO17200.1 - 0.0011 17.7 4.1 1.5 7.4 0.5 3.6 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO17202.1 - 2.5e-05 25.0 0.2 0.00019 22.2 0.2 2.5 2 1 0 2 2 2 1 WD domain, G-beta repeat S1_2 PF13509.6 ETO17202.1 - 0.0046 17.0 0.0 0.042 13.9 0.0 2.3 2 0 0 2 2 2 1 S1 domain Fez1 PF06818.15 ETO17202.1 - 0.042 14.3 3.6 0.088 13.2 3.6 1.5 1 1 0 1 1 1 0 Fez1 FlaC_arch PF05377.11 ETO17202.1 - 0.27 11.6 4.8 2.6 8.5 0.1 2.5 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) NAD_binding_1 PF00175.21 ETO17202.1 - 0.54 10.9 1.8 2.4 8.8 0.3 2.6 1 1 3 4 4 4 0 Oxidoreductase NAD-binding domain Spc24 PF08286.11 ETO17202.1 - 5.6 7.2 10.3 6 7.2 0.7 3.0 3 1 0 3 3 3 0 Spc24 subunit of Ndc80 MID_MedPIWI PF18296.1 ETO17204.1 - 0.1 12.4 14.4 0.88 9.3 1.9 2.2 2 0 0 2 2 2 0 MID domain of medPIWI CCDC106 PF15794.5 ETO17204.1 - 10 5.8 22.7 0.27 10.9 10.0 3.0 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 106 Chorion_2 PF03964.15 ETO17205.1 - 0.0043 17.9 3.0 0.0077 17.0 3.0 1.3 1 0 0 1 1 1 1 Chorion family 2 PAP1 PF08601.10 ETO17205.1 - 0.0092 15.7 14.6 0.012 15.3 14.6 1.1 1 0 0 1 1 1 1 Transcription factor PAP1 AF-4 PF05110.13 ETO17205.1 - 0.015 13.4 7.2 0.019 13.1 7.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SR-25 PF10500.9 ETO17205.1 - 0.22 11.1 10.8 0.32 10.6 10.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ABC_membrane_2 PF06472.15 ETO17206.1 - 7.8e-46 156.6 0.1 1.2e-45 156.0 0.0 1.3 2 0 0 2 2 2 1 ABC transporter transmembrane region 2 Ank_2 PF12796.7 ETO17207.1 - 0.01 16.4 0.3 0.036 14.7 0.1 1.9 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) FGF PF00167.18 ETO17207.1 - 0.047 13.8 0.2 0.067 13.3 0.2 1.3 1 0 0 1 1 1 0 Fibroblast growth factor DUF5497 PF17601.2 ETO17208.1 - 0.02 15.2 0.4 5 7.5 0.0 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5497) IQ_SEC7_PH PF16453.5 ETO17208.1 - 0.023 14.7 0.1 0.06 13.3 0.1 1.7 1 0 0 1 1 1 0 PH domain DUF5427 PF10310.9 ETO17208.1 - 0.055 12.4 0.3 0.085 11.8 0.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) PH_3 PF14593.6 ETO17208.1 - 0.071 13.2 0.3 0.16 12.1 0.3 1.6 1 0 0 1 1 1 0 PH domain TIP120 PF08623.10 ETO17208.1 - 0.088 12.6 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 TATA-binding protein interacting (TIP20) PH_10 PF15411.6 ETO17208.1 - 0.11 12.7 1.2 0.74 10.1 1.2 2.2 1 1 0 1 1 1 0 Pleckstrin homology domain DUF4834 PF16118.5 ETO17209.1 - 0.019 15.9 6.3 4.4 8.3 3.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) S-antigen PF05756.11 ETO17209.1 - 0.085 13.2 0.1 0.32 11.4 0.1 2.0 1 0 0 1 1 1 0 S-antigen protein SPP PF06550.11 ETO17209.1 - 3.3 7.1 7.2 4.3 6.7 1.6 2.4 2 0 0 2 2 2 0 Signal-peptide peptidase, presenilin aspartyl protease 6PF2K PF01591.18 ETO17211.1 - 1.1e-47 162.2 0.2 1.6e-47 161.7 0.2 1.3 1 0 0 1 1 1 1 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ETO17211.1 - 3.7e-39 134.4 0.0 1e-38 133.0 0.0 1.7 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Val_tRNA-synt_C PF10458.9 ETO17211.1 - 0.045 14.0 0.2 0.12 12.6 0.2 1.7 1 0 0 1 1 1 0 Valyl tRNA synthetase tRNA binding arm Sec3_C PF09763.9 ETO17212.1 - 1.2e-08 33.9 7.2 1.3e-08 33.7 7.2 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 SNAP PF14938.6 ETO17214.1 - 1.6e-18 67.2 1.5 2e-18 66.8 1.5 1.1 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP RTP1_C1 PF10363.9 ETO17215.1 - 7.3e-05 22.9 0.1 0.019 15.1 0.0 2.4 2 0 0 2 2 2 2 Required for nuclear transport of RNA pol II C-terminus 1 Cnd1 PF12717.7 ETO17215.1 - 0.0093 16.0 0.1 3.9 7.5 0.0 2.7 2 1 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 TIP120 PF08623.10 ETO17215.1 - 0.12 12.1 0.1 0.12 12.1 0.1 2.8 2 1 2 4 4 4 0 TATA-binding protein interacting (TIP20) UVR PF02151.19 ETO17216.1 - 5.7e-08 32.3 10.7 0.0015 18.2 4.3 2.3 2 0 0 2 2 2 2 UvrB/uvrC motif IMD PF08397.11 ETO17216.1 - 0.049 13.0 10.1 0.066 12.6 9.4 1.5 1 1 0 1 1 1 0 IRSp53/MIM homology domain Menin PF05053.13 ETO17216.1 - 1.2 7.4 12.3 1.8 6.9 12.3 1.2 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO17216.1 - 3.2 8.4 20.6 8.7 7.0 20.6 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain PA26 PF04636.13 ETO17217.1 - 0.72 8.7 8.3 0.78 8.6 8.3 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DEC-1_N PF04625.13 ETO17217.1 - 1.4 7.9 5.9 1.9 7.4 5.9 1.3 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region CDC27 PF09507.10 ETO17217.1 - 1.8 7.9 30.4 2 7.7 30.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF966 PF06136.13 ETO17217.1 - 4.7 6.8 17.9 5.3 6.7 17.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Hamartin PF04388.12 ETO17217.1 - 4.7 5.8 14.7 5.3 5.6 14.7 1.0 1 0 0 1 1 1 0 Hamartin protein Nop14 PF04147.12 ETO17217.1 - 7.3 4.7 25.5 7.9 4.5 25.5 1.1 1 0 0 1 1 1 0 Nop14-like family Nop14 PF04147.12 ETO17218.1 - 5 5.2 15.2 5.9 5.0 15.2 1.0 1 0 0 1 1 1 0 Nop14-like family APG6_N PF17675.1 ETO17220.1 - 0.4 11.2 23.0 0.052 14.1 17.4 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region LAG1-DNAbind PF09271.11 ETO17220.1 - 4.6 7.8 7.3 1.1 9.9 2.2 2.1 2 0 0 2 2 2 0 LAG1, DNA binding DUF4484 PF14831.6 ETO17220.1 - 8.7 6.3 8.7 2 8.4 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) RGS PF00615.19 ETO17221.1 - 7.1e-07 29.5 2.1 1e-06 29.0 2.1 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4803 PF16061.5 ETO17221.1 - 0.0063 16.0 0.3 0.0082 15.6 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4803) TPR_12 PF13424.6 ETO17222.1 - 1.2e-05 25.5 0.4 0.071 13.4 0.0 2.2 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17222.1 - 0.0013 18.6 0.8 0.57 10.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17222.1 - 0.012 15.5 0.1 0.026 14.4 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Methyltransf_33 PF10017.9 ETO17222.1 - 0.033 13.4 0.1 0.048 12.8 0.1 1.4 1 0 0 1 1 1 0 Histidine-specific methyltransferase, SAM-dependent Lipoprotein_3 PF00938.17 ETO17222.1 - 0.13 12.5 3.0 0.9 9.8 0.2 2.4 2 0 0 2 2 2 0 Lipoprotein TPR_1 PF00515.28 ETO17222.1 - 0.25 11.2 2.5 0.92 9.4 0.5 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat PS_Dcarbxylase PF02666.15 ETO17223.1 - 9.3e-47 159.2 0.2 6.5e-46 156.4 0.2 2.1 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase EF-hand_6 PF13405.6 ETO17223.1 - 1.6e-07 30.7 0.3 0.016 15.1 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO17223.1 - 0.019 14.5 2.5 0.54 9.9 0.1 2.7 2 0 0 2 2 2 0 EF hand EF-hand_7 PF13499.6 ETO17223.1 - 0.02 15.3 0.6 0.053 14.0 0.6 1.7 1 0 0 1 1 1 0 EF-hand domain pair NOA36 PF06524.12 ETO17224.1 - 0.0041 16.5 7.9 0.0052 16.1 7.9 1.3 1 0 0 1 1 1 1 NOA36 protein NESP55 PF06390.12 ETO17224.1 - 0.0066 16.1 1.7 0.0081 15.8 1.1 1.3 1 1 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) ABC2_membrane PF01061.24 ETO17225.1 - 9.2e-08 31.7 3.5 1.3e-07 31.2 3.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter DUF2207 PF09972.9 ETO17225.1 - 0.18 10.5 2.6 0.2 10.4 1.4 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) TPR_12 PF13424.6 ETO17226.1 - 1.8e-27 95.4 5.0 1.5e-12 47.6 0.7 3.4 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17226.1 - 4.1e-19 67.8 2.1 2.1e-06 27.4 0.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17226.1 - 1e-18 66.3 21.1 1.4e-07 31.0 1.8 5.6 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17226.1 - 2.6e-17 61.5 17.2 1.3e-06 28.0 0.7 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17226.1 - 5.9e-16 57.2 4.5 0.00032 20.5 0.1 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17226.1 - 1.5e-11 43.5 19.9 0.002 18.2 1.4 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17226.1 - 1.9e-05 25.1 0.0 10 7.2 0.0 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17226.1 - 0.00021 21.4 10.1 0.2 12.1 0.6 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17226.1 - 0.0011 18.6 20.3 0.091 12.5 0.8 6.2 4 1 1 5 5 5 2 TPR repeat TPR_6 PF13174.6 ETO17226.1 - 0.0067 17.0 1.4 33 5.4 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO17226.1 - 0.0096 15.9 3.0 0.015 15.3 0.2 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO17226.1 - 0.015 14.7 0.0 0.026 13.9 0.0 1.4 1 0 0 1 1 1 0 MalT-like TPR region Colicin_immun PF09204.10 ETO17226.1 - 0.028 14.9 2.3 2.3 8.8 0.2 3.1 2 0 0 2 2 2 0 Bacterial self-protective colicin-like immunity TPR_19 PF14559.6 ETO17226.1 - 0.12 12.9 0.8 13 6.4 0.1 2.9 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17226.1 - 1.9 8.8 13.8 1.7e+02 2.5 10.4 3.7 2 2 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO17226.1 - 2.9 8.0 12.0 0.54 10.4 0.3 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain WD40 PF00400.32 ETO17227.1 - 2.1e-16 60.0 7.9 6.2e-05 23.7 0.1 5.3 5 2 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO17227.1 - 2.2e-06 26.6 0.9 0.039 12.6 0.1 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO17227.1 - 0.00043 20.5 0.1 1.1 9.6 0.0 3.5 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain MerR PF00376.23 ETO17227.1 - 0.14 12.0 0.1 31 4.4 0.0 3.2 3 0 0 3 3 3 0 MerR family regulatory protein MCR_C PF04609.12 ETO17228.1 - 0.0056 15.8 0.4 0.0067 15.5 0.4 1.1 1 0 0 1 1 1 1 Methyl-coenzyme M reductase operon protein C HSP70 PF00012.20 ETO17229.1 - 5.8e-32 110.6 1.5 3.1e-18 65.3 0.1 2.2 1 1 1 2 2 2 2 Hsp70 protein Flu_C_NS2 PF03555.14 ETO17229.1 - 0.014 15.6 0.3 0.049 13.8 0.0 2.0 2 0 0 2 2 2 0 Influenza C non-structural protein (NS2) CDC45 PF02724.14 ETO17230.1 - 0.00015 20.2 3.9 0.00018 20.0 3.9 1.0 1 0 0 1 1 1 1 CDC45-like protein Velvet PF11754.8 ETO17230.1 - 0.00021 21.3 0.7 0.00029 20.9 0.7 1.1 1 0 0 1 1 1 1 Velvet factor Membralin PF09746.9 ETO17230.1 - 0.93 8.5 5.8 1.1 8.2 5.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO17230.1 - 1.9 7.2 9.0 2 7.1 9.0 1.2 1 0 0 1 1 1 0 Presenilin Pannexin_like PF12534.8 ETO17230.1 - 1.9 7.5 10.3 2.9 6.9 10.3 1.3 1 1 0 1 1 1 0 Pannexin-like TM region of LRRC8 Chlam_PMP PF02415.17 ETO17234.1 - 1.5e-05 25.2 23.0 0.1 13.2 0.2 6.2 6 0 0 6 6 6 3 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat CX PF01705.19 ETO17234.1 - 0.022 15.3 1.3 3.9 8.1 0.1 3.3 2 1 1 3 3 3 0 CX module DUF4734 PF15881.5 ETO17234.1 - 0.076 13.2 0.2 0.16 12.1 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4734) DUF3439 PF11921.8 ETO17235.1 - 0.0035 17.3 7.4 0.0098 15.9 7.4 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO17235.1 - 0.27 11.2 18.1 0.5 10.4 18.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 ETO17235.1 - 0.45 8.6 13.5 0.7 8.0 13.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TPR_2 PF07719.17 ETO17237.1 - 2e-22 77.4 19.8 0.0039 17.2 0.4 8.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17237.1 - 4.1e-15 54.7 17.9 0.0012 18.9 0.1 8.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17237.1 - 5.5e-15 54.5 28.1 0.0043 16.8 0.3 9.4 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17237.1 - 3.5e-12 46.1 3.5 0.26 12.2 0.0 6.6 3 1 3 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17237.1 - 5.5e-11 42.0 16.6 6.8e-05 22.5 0.4 6.2 4 1 2 6 6 6 3 TPR repeat TPR_12 PF13424.6 ETO17237.1 - 1e-09 38.5 16.4 2.1e-06 28.0 2.5 6.0 3 2 4 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17237.1 - 4.1e-09 37.0 0.2 0.098 13.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17237.1 - 1.3e-07 31.5 17.3 0.017 15.4 0.2 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO17237.1 - 2.1e-07 30.6 1.2 0.0058 16.0 0.2 3.3 3 0 0 3 3 3 2 MalT-like TPR region SAM_1 PF00536.30 ETO17237.1 - 5.3e-07 30.0 0.2 1.6e-06 28.5 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_19 PF14559.6 ETO17237.1 - 6.3e-07 29.8 8.4 0.14 12.7 0.0 5.6 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17237.1 - 1e-05 25.2 14.7 0.15 12.1 0.1 6.2 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17237.1 - 1e-05 25.2 11.3 0.25 11.3 0.1 6.1 7 0 0 7 7 5 2 Tetratricopeptide repeat SAM_2 PF07647.17 ETO17237.1 - 1.3e-05 25.2 0.2 4.9e-05 23.3 0.2 2.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Suf PF05843.14 ETO17237.1 - 0.13 12.2 0.0 0.13 12.2 0.0 2.3 2 1 0 2 2 1 0 Suppressor of forked protein (Suf) TPR_6 PF13174.6 ETO17237.1 - 0.63 10.8 2.9 1.5e+02 3.3 0.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ETO17237.1 - 6.3 6.8 15.9 3.7 7.6 0.1 5.5 7 1 1 8 8 6 0 Mad3/BUB1 homology region 1 MIT PF04212.18 ETO17237.1 - 6.5 6.9 15.0 37 4.5 0.0 6.0 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain PRIMA1 PF16101.5 ETO17237.1 - 6.5 6.8 7.8 18 5.4 7.8 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 UL42 PF17638.2 ETO17237.1 - 8.9 6.3 7.7 10 6.1 6.3 1.8 2 0 0 2 2 1 0 HCMV UL42 Zip PF02535.22 ETO17239.1 - 0.16 11.1 12.3 0.24 10.6 0.6 2.5 2 0 0 2 2 2 0 ZIP Zinc transporter HCO3_cotransp PF00955.21 ETO17239.1 - 9.8 4.9 10.3 0.32 9.8 4.0 1.6 2 0 0 2 2 2 0 HCO3- transporter family DAO PF01266.24 ETO17240.1 - 8.6e-12 45.3 0.5 5.4e-07 29.5 0.1 2.1 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETO17240.1 - 0.0008 18.6 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain NAD_binding_8 PF13450.6 ETO17240.1 - 0.0024 18.1 0.1 0.0049 17.1 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETO17240.1 - 0.019 14.2 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETO17240.1 - 0.019 14.2 0.0 0.032 13.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain Thi4 PF01946.17 ETO17240.1 - 0.04 13.2 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Thi4 family FGE-sulfatase PF03781.16 ETO17241.1 - 2.2e-07 30.7 0.0 3.5e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 Sulfatase-modifying factor enzyme 1 Methyltransf_23 PF13489.6 ETO17241.1 - 8.2e-06 25.7 0.0 2.7e-05 24.1 0.0 1.8 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO17241.1 - 2.6e-05 24.8 0.5 0.00019 22.0 0.5 2.3 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO17241.1 - 4.2e-05 23.4 0.1 0.0001 22.1 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO17241.1 - 7e-05 23.5 1.3 0.00052 20.7 0.2 2.4 1 1 1 2 2 2 1 Methyltransferase domain DREV PF05219.12 ETO17241.1 - 0.0017 17.5 0.1 0.0031 16.7 0.1 1.4 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_25 PF13649.6 ETO17241.1 - 0.0044 17.7 0.2 0.043 14.5 0.0 2.5 2 1 1 3 3 3 1 Methyltransferase domain Parathyroid PF01279.17 ETO17242.1 - 0.022 15.4 1.9 0.031 14.9 1.9 1.2 1 0 0 1 1 1 0 Parathyroid hormone family GOLD_2 PF13897.6 ETO17242.1 - 0.052 14.0 1.7 0.078 13.5 1.7 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking THOC2_N PF16134.5 ETO17242.1 - 0.84 8.2 5.3 1.2 7.7 5.3 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Pkinase PF00069.25 ETO17243.1 - 9.2e-62 208.8 0.1 1.9e-48 165.1 0.3 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17243.1 - 7.3e-29 100.8 0.1 5.6e-26 91.4 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO17243.1 - 0.0077 15.6 0.1 0.02 14.3 0.1 1.6 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RdRP PF05183.12 ETO17248.1 - 6.4e-21 74.6 0.9 1.2e-20 73.8 0.9 1.3 1 0 0 1 1 1 1 RNA dependent RNA polymerase zf-CCCH_3 PF15663.5 ETO17248.1 - 0.063 13.5 0.0 0.23 11.7 0.0 1.9 1 0 0 1 1 1 0 Zinc-finger containing family Vfa1 PF08432.10 ETO17248.1 - 6.9 7.0 19.6 0.17 12.2 8.3 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CTP_transf_like PF01467.26 ETO17249.1 - 2.9e-11 43.7 0.1 4.9e-11 43.0 0.1 1.4 1 0 0 1 1 1 1 Cytidylyltransferase-like Pantoate_ligase PF02569.15 ETO17249.1 - 0.065 12.4 0.0 0.1 11.8 0.0 1.2 1 0 0 1 1 1 0 Pantoate-beta-alanine ligase HIGH_NTase1 PF05636.11 ETO17249.1 - 0.069 12.3 0.8 0.24 10.6 0.0 2.1 3 0 0 3 3 3 0 HIGH Nucleotidyl Transferase Kelch_5 PF13854.6 ETO17250.1 - 3.5e-11 42.8 0.3 0.034 14.2 0.0 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETO17250.1 - 1.2e-08 34.9 0.0 0.0002 21.3 0.0 4.2 4 1 1 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO17250.1 - 1.4e-08 34.1 0.1 0.0044 16.6 0.0 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO17250.1 - 1.2e-06 28.6 0.3 0.28 11.5 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO17250.1 - 3.6e-06 27.1 0.0 0.00031 21.0 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO17250.1 - 0.0017 18.2 6.0 0.067 13.2 0.1 4.4 5 1 0 5 5 5 1 Kelch motif WD40 PF00400.32 ETO17251.1 - 2.6e-44 148.3 13.4 4e-09 36.9 0.1 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17251.1 - 2.1e-18 66.4 0.4 0.038 14.3 0.0 6.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17251.1 - 4.5e-11 42.3 0.4 0.016 14.1 0.0 4.4 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO17251.1 - 5e-08 32.6 1.7 0.0019 17.6 0.1 4.1 3 2 2 5 5 5 2 WD40-like domain PD40 PF07676.12 ETO17251.1 - 1.4e-07 31.3 6.0 0.004 17.1 0.2 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO17251.1 - 0.00014 20.5 0.2 0.13 10.8 0.0 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain Utp8 PF10395.9 ETO17251.1 - 0.00025 19.7 0.1 0.19 10.2 0.0 2.3 2 0 0 2 2 2 2 Utp8 family IKI3 PF04762.12 ETO17251.1 - 0.0016 16.6 0.2 0.028 12.4 0.1 2.2 1 1 0 2 2 2 1 IKI3 family POLO_box PF00659.18 ETO17251.1 - 0.014 15.6 2.0 6.8 7.0 0.1 3.6 4 1 0 4 4 4 0 POLO box duplicated region DUF2963 PF11178.8 ETO17251.1 - 0.11 12.2 0.0 50 3.7 0.0 3.5 5 0 0 5 5 5 0 Protein of unknown function (DUF2963) Proteasome_A_N PF10584.9 ETO17251.1 - 4 7.2 5.2 17 5.2 0.1 3.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Mad3_BUB1_I PF08311.12 ETO17252.1 - 5.5e-32 110.4 7.9 5.5e-32 110.4 7.9 2.4 2 1 0 2 2 2 1 Mad3/BUB1 homology region 1 ERp29 PF07749.12 ETO17253.1 - 0.037 14.9 0.6 0.13 13.2 0.1 2.1 2 0 0 2 2 2 0 Endoplasmic reticulum protein ERp29, C-terminal domain DUF2378 PF09536.10 ETO17253.1 - 0.11 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2378) 7TM_GPCR_Srv PF10323.9 ETO17254.1 - 0.16 11.3 0.0 0.32 10.3 0.0 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv HSBP1 PF06825.12 ETO17255.1 - 0.012 15.4 2.0 0.02 14.7 2.0 1.3 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Orf78 PF06024.12 ETO17255.1 - 0.036 14.4 0.1 0.043 14.1 0.1 1.2 1 0 0 1 1 1 0 Orf78 (ac78) DUF4193 PF13834.6 ETO17255.1 - 0.091 13.3 0.2 0.11 13.0 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) Thioredoxin PF00085.20 ETO17257.1 - 4e-26 91.0 4.2 4.9e-16 58.6 2.1 3.5 2 1 0 2 2 2 2 Thioredoxin Thioredoxin_2 PF13098.6 ETO17257.1 - 4.2e-05 23.9 0.5 0.0014 19.1 0.2 2.6 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ETO17257.1 - 8.9e-05 22.7 2.2 0.53 10.7 1.0 3.5 2 1 0 2 2 2 2 Thioredoxin-like Thioredoxin_7 PF13899.6 ETO17257.1 - 0.0046 17.1 2.1 6.2 7.1 0.0 3.6 2 1 0 2 2 2 2 Thioredoxin-like ATE_C PF04377.15 ETO17257.1 - 0.016 15.8 1.4 0.29 11.7 0.1 2.9 3 0 0 3 3 3 0 Arginine-tRNA-protein transferase, C terminus AhpC-TSA PF00578.21 ETO17257.1 - 0.026 14.5 0.7 1.9 8.4 0.0 3.0 3 0 0 3 3 3 0 AhpC/TSA family RRM_1 PF00076.22 ETO17258.1 - 5.1e-12 45.4 0.1 3.3e-05 23.6 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO17258.1 - 0.0012 18.8 0.0 0.0037 17.3 0.0 1.8 2 0 0 2 2 2 1 RNA binding motif DUF1866 PF08952.11 ETO17258.1 - 0.019 14.8 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1866) RRM_Rrp7 PF17799.1 ETO17258.1 - 0.12 12.1 3.6 1.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Rrp7 RRM-like N-terminal domain TbpB_A PF17484.2 ETO17259.1 - 0.15 12.8 3.0 0.12 13.2 0.7 2.0 2 0 0 2 2 2 0 N-Lobe handle Tf-binding protein B EMC3_TMCO1 PF01956.16 ETO17260.1 - 0.028 14.2 0.1 0.028 14.2 0.1 2.0 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like DUF4446 PF14584.6 ETO17260.1 - 0.038 14.0 0.9 0.038 14.0 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) XRN_M PF17846.1 ETO17260.1 - 0.056 12.4 5.7 0.066 12.2 5.7 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Neur_chan_memb PF02932.16 ETO17260.1 - 0.072 13.1 1.3 0.11 12.5 1.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4834 PF16118.5 ETO17260.1 - 0.23 12.4 11.3 1.1 10.3 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SLC12 PF03522.15 ETO17260.1 - 0.49 9.4 7.3 0.6 9.1 7.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 ETO17260.1 - 0.94 7.5 12.7 1.1 7.3 12.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Suf PF05843.14 ETO17260.1 - 2.6 8.0 10.6 3.2 7.6 10.6 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Tim54 PF11711.8 ETO17260.1 - 8.6 5.0 16.3 0.56 8.9 1.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Radial_spoke PF04712.12 ETO17261.1 - 0.065 12.2 1.0 0.086 11.8 1.0 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Ferlin_C PF16165.5 ETO17261.1 - 0.11 12.5 0.9 0.18 11.7 0.9 1.3 1 0 0 1 1 1 0 Ferlin C-terminus SUIM_assoc PF16619.5 ETO17262.1 - 0.086 12.9 0.2 0.086 12.9 0.2 3.2 4 0 0 4 4 4 0 Unstructured region C-term to UIM in Ataxin3 DUF4266 PF14086.6 ETO17262.1 - 4.2 8.4 7.8 2.6 9.1 1.4 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4266) CDC50 PF03381.15 ETO17263.1 - 2e-24 86.6 0.3 2.7e-24 86.2 0.3 1.2 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family DUF2839 PF10999.8 ETO17263.1 - 0.006 16.9 0.5 0.006 16.9 0.5 2.1 1 1 2 3 3 3 1 Protein of unknown function (DUF2839) DUF4718 PF15842.5 ETO17263.1 - 0.11 12.3 0.2 0.16 11.7 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) CcmD PF04995.14 ETO17263.1 - 0.67 10.1 0.1 0.67 10.1 0.1 2.2 2 0 0 2 2 2 0 Heme exporter protein D (CcmD) Glyco_hydro_3_C PF01915.22 ETO17264.1 - 2.8e-28 99.3 0.0 3.1e-28 99.1 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain MMM1 PF10296.9 ETO17265.1 - 0.3 10.1 7.0 0.3 10.1 7.0 1.0 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF1003 PF06210.11 ETO17265.1 - 0.36 10.9 2.4 0.41 10.8 2.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) CLN3 PF02487.17 ETO17265.1 - 2.5 7.0 3.9 2.5 7.1 3.9 1.0 1 0 0 1 1 1 0 CLN3 protein DUF5355 PF17306.2 ETO17265.1 - 5.3 6.0 17.6 5.6 5.9 17.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5355) UQ_con PF00179.26 ETO17266.1 - 7.5e-37 126.1 0.0 1.9e-36 124.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PKD_channel PF08016.12 ETO17267.1 - 1e-10 40.9 12.4 1e-10 40.9 12.4 1.5 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 ETO17267.1 - 2.7e-06 26.8 20.0 6.1e-06 25.6 19.4 1.9 1 1 0 1 1 1 1 Ion transport protein Mucin PF01456.17 ETO17268.1 - 0.022 14.8 1.9 0.024 14.6 0.1 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein CAC1F_C PF16885.5 ETO17268.1 - 0.033 13.8 0.0 0.087 12.5 0.0 1.7 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term UCH PF00443.29 ETO17269.1 - 4e-09 36.4 0.0 4e-09 36.4 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ETO17269.1 - 1e-06 28.6 0.0 1.4e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal UCH_1 PF13423.6 ETO17269.1 - 0.00031 20.4 0.0 0.00039 20.1 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase zf-H2C2_5 PF13909.6 ETO17269.1 - 5.8 6.8 6.5 0.58 10.0 1.3 2.2 2 1 1 3 3 3 0 C2H2-type zinc-finger domain UPF0542 PF15086.6 ETO17270.1 - 0.0038 17.1 2.3 0.0038 17.1 2.3 2.6 2 0 0 2 2 2 1 Uncharacterised protein family UPF0542 7TM_GPCR_Sru PF10322.9 ETO17270.1 - 0.008 15.5 1.1 0.008 15.5 1.1 1.4 1 1 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Sru DUF4834 PF16118.5 ETO17270.1 - 0.011 16.7 7.0 0.019 15.9 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CSG2 PF16965.5 ETO17270.1 - 0.06 12.3 2.8 0.075 12.0 2.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Connexin PF00029.19 ETO17270.1 - 0.089 12.5 9.3 0.065 13.0 7.9 1.4 1 1 0 1 1 1 0 Connexin ALMT PF11744.8 ETO17270.1 - 0.093 11.5 7.1 0.13 11.1 7.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter PigN PF04987.14 ETO17270.1 - 0.22 10.4 2.0 0.36 9.6 2.0 1.3 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Med19 PF10278.9 ETO17270.1 - 1.2 9.0 17.2 3.1 7.7 17.2 1.6 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 SieB PF14163.6 ETO17270.1 - 5.7 6.4 8.6 1.9 8.0 0.4 3.5 3 1 1 4 4 4 0 Super-infection exclusion protein B DivIC PF04977.15 ETO17270.1 - 7 6.5 10.5 0.42 10.4 0.4 3.3 3 1 0 3 3 3 0 Septum formation initiator FAM176 PF14851.6 ETO17272.1 - 0.016 14.9 0.9 0.029 14.0 0.9 1.4 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 ETO17272.1 - 0.017 15.3 4.4 0.032 14.4 4.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 ETO17272.1 - 0.018 15.4 10.6 0.049 14.0 10.6 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ETO17272.1 - 0.024 14.4 6.2 0.032 14.0 6.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RXT2_N PF08595.11 ETO17272.1 - 0.054 13.5 3.2 0.11 12.5 3.2 1.5 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_Ag35 PF03286.14 ETO17272.1 - 0.11 12.3 1.8 0.18 11.6 1.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PPP4R2 PF09184.11 ETO17272.1 - 0.13 11.8 3.3 0.18 11.4 3.3 1.3 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 ETO17272.1 - 0.15 10.3 3.3 0.18 10.0 3.3 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO17272.1 - 0.19 10.0 2.4 0.23 9.7 2.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.13 ETO17272.1 - 0.21 10.1 5.4 0.3 9.6 5.4 1.1 1 0 0 1 1 1 0 Utp14 protein Sporozoite_P67 PF05642.11 ETO17272.1 - 0.57 8.2 2.2 0.76 7.8 2.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-C2HE PF16278.5 ETO17272.1 - 1.2 9.6 3.9 0.42 11.1 0.5 2.1 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger YL1 PF05764.13 ETO17272.1 - 2.7 8.1 9.5 4.7 7.3 9.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 ETO17272.1 - 3.5 6.9 17.9 1.7 7.9 14.3 1.9 2 0 0 2 2 2 0 NOA36 protein SNF2_N PF00176.23 ETO17273.1 - 1.3e-43 149.0 0.0 4e-43 147.5 0.0 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain DUF2073 PF09846.9 ETO17273.1 - 0.035 14.0 0.0 0.078 12.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2073) RGS PF00615.19 ETO17274.1 - 2.2e-09 37.6 0.0 1e-08 35.4 0.0 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain HEAT_2 PF13646.6 ETO17275.1 - 0.0063 16.9 0.0 0.7 10.3 0.0 2.3 2 1 0 2 2 2 1 HEAT repeats NLE PF08154.12 ETO17275.1 - 0.033 14.7 1.2 4.7 7.8 0.0 3.1 2 1 1 3 3 3 0 NLE (NUC135) domain RsfS PF02410.15 ETO17275.1 - 0.052 14.0 0.1 2 8.9 0.1 2.4 1 1 0 1 1 1 0 Ribosomal silencing factor during starvation Colicin-DNase PF12639.7 ETO17275.1 - 0.058 14.2 0.3 0.24 12.2 0.1 2.1 2 1 0 2 2 2 0 DNase/tRNase domain of colicin-like bacteriocin HEAT PF02985.22 ETO17275.1 - 0.08 13.2 0.1 0.41 11.0 0.0 2.3 2 0 0 2 2 2 0 HEAT repeat Vac14_Fab1_bd PF12755.7 ETO17275.1 - 0.085 13.5 0.2 0.66 10.6 0.0 2.1 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region HEAT_EZ PF13513.6 ETO17275.1 - 0.085 13.4 0.0 2.3 8.8 0.0 2.7 3 0 0 3 3 3 0 HEAT-like repeat Arm-DNA-bind_2 PF12167.8 ETO17275.1 - 0.1 12.5 0.0 0.36 10.8 0.0 1.9 2 0 0 2 2 2 0 Arm DNA-binding domain HTH_10 PF04967.12 ETO17275.1 - 0.11 12.4 0.1 1.2 9.0 0.1 2.4 2 0 0 2 2 2 0 HTH DNA binding domain HEAT_PBS PF03130.16 ETO17275.1 - 0.12 13.1 0.0 26 5.9 0.0 3.0 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DUF1700 PF08006.11 ETO17277.1 - 0.00064 19.3 1.4 0.0008 19.0 1.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1700) DUF2101 PF09874.9 ETO17277.1 - 0.026 14.3 4.0 0.031 14.0 4.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) Cas9_C PF18525.1 ETO17277.1 - 0.031 14.5 1.0 0.48 10.6 0.9 2.0 1 1 1 2 2 2 0 Cas9 C-terminal domain Sec62 PF03839.16 ETO17277.1 - 0.048 13.2 0.1 0.056 13.0 0.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DDE_3 PF13358.6 ETO17278.1 - 7.9e-05 22.5 1.2 7.9e-05 22.5 1.2 1.8 1 1 1 2 2 2 1 DDE superfamily endonuclease Indigoidine_A PF04227.12 ETO17280.1 - 2e-127 424.5 1.7 3.2e-127 423.9 1.7 1.3 1 0 0 1 1 1 1 Indigoidine synthase A like protein PfkB PF00294.24 ETO17280.1 - 6.1e-28 98.0 0.0 1.2e-27 97.1 0.0 1.4 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Arm PF00514.23 ETO17281.1 - 3.7e-22 77.6 0.4 4.3e-05 23.4 0.0 6.1 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO17281.1 - 0.0024 18.3 0.0 4.6 7.8 0.0 3.7 3 1 1 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 ETO17281.1 - 0.0038 17.3 0.4 0.025 14.6 0.0 2.4 3 0 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO17281.1 - 0.012 16.0 0.0 6.3 7.3 0.0 2.6 3 0 0 3 3 3 0 HEAT repeats Peptidase_C14 PF00656.22 ETO17282.1 - 4.3e-14 53.1 0.8 3.4e-13 50.1 0.3 2.4 2 0 0 2 2 2 1 Caspase domain RsgA_GTPase PF03193.16 ETO17282.1 - 5.1e-05 23.3 0.1 0.0002 21.3 0.1 2.0 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ETO17282.1 - 7.1e-05 23.3 0.0 0.00031 21.3 0.0 2.1 1 0 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ETO17282.1 - 0.0021 17.8 0.0 0.012 15.4 0.0 2.1 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO17282.1 - 0.0079 16.5 0.1 0.19 12.0 0.0 3.1 2 0 0 2 2 2 1 AAA domain NblA PF04485.12 ETO17282.1 - 0.013 15.9 1.8 0.026 14.9 0.1 2.5 2 0 0 2 2 2 0 Phycobilisome degradation protein nblA DUF815 PF05673.13 ETO17282.1 - 0.027 13.6 0.1 0.078 12.1 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_16 PF13191.6 ETO17282.1 - 0.032 14.6 0.1 0.16 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain MMR_HSR1 PF01926.23 ETO17282.1 - 0.034 14.2 0.1 0.26 11.4 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_23 PF13476.6 ETO17282.1 - 0.05 14.1 0.0 0.05 14.1 0.0 4.5 2 1 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 ETO17282.1 - 0.09 13.2 0.9 8.7 6.8 0.0 3.4 2 0 0 2 2 2 0 RNA helicase AAA_30 PF13604.6 ETO17282.1 - 0.12 12.0 0.0 0.28 10.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO17282.1 - 0.23 11.6 0.5 0.64 10.2 0.1 2.0 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 ETO17282.1 - 0.68 10.5 3.0 0.68 10.5 0.0 2.7 3 0 0 3 3 1 0 AAA domain RNA_pol_Rpb1_4 PF05000.17 ETO17282.1 - 1.6 8.7 3.7 2.2 8.2 0.0 3.2 3 0 0 3 3 3 0 RNA polymerase Rpb1, domain 4 Plasmodium_Vir PF05795.11 ETO17283.1 - 0.00071 19.1 3.9 0.00096 18.7 3.9 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF4407 PF14362.6 ETO17283.1 - 0.0047 16.3 15.3 0.0058 16.0 15.3 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) LMBR1 PF04791.16 ETO17283.1 - 0.46 9.3 11.1 0.58 9.0 11.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein cNMP_binding PF00027.29 ETO17284.1 - 7.1e-06 26.0 0.0 1.1e-05 25.4 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CDC45 PF02724.14 ETO17284.1 - 0.027 12.8 11.4 0.024 12.9 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO17284.1 - 0.098 13.1 5.2 0.12 12.8 5.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 ETO17284.1 - 0.18 11.6 11.0 0.23 11.3 11.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.5 ETO17284.1 - 0.53 10.1 13.7 0.74 9.6 13.7 1.2 1 0 0 1 1 1 0 Coilin N-terminus TFIIF_alpha PF05793.12 ETO17284.1 - 1.1 7.7 28.0 1.5 7.3 28.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Zip PF02535.22 ETO17284.1 - 1.1 8.4 3.4 1.2 8.3 3.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_polI_A34 PF08208.11 ETO17284.1 - 1.5 8.9 26.2 2.2 8.3 26.2 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Ion_trans PF00520.31 ETO17285.1 - 1.2e-33 116.4 51.2 1.7e-24 86.4 19.1 3.0 3 0 0 3 3 3 2 Ion transport protein cNMP_binding PF00027.29 ETO17285.1 - 0.00021 21.3 0.0 0.00057 19.9 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DEP PF00610.21 ETO17285.1 - 0.00072 19.6 0.0 0.0021 18.1 0.0 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_6 PF13405.6 ETO17285.1 - 0.069 13.1 0.0 4.8 7.4 0.0 3.2 2 0 0 2 2 2 0 EF-hand domain Macoilin PF09726.9 ETO17285.1 - 2.1 6.8 11.4 3.1 6.2 11.4 1.2 1 0 0 1 1 1 0 Macoilin family Secretin_N_2 PF07655.13 ETO17285.1 - 3.8 8.1 22.3 1.9 9.1 19.3 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain DUF1336 PF07059.12 ETO17286.1 - 7.8e-24 85.0 0.0 2.1e-23 83.6 0.0 1.7 2 1 0 2 2 2 1 Protein of unknown function (DUF1336) DUF3439 PF11921.8 ETO17286.1 - 0.16 12.0 7.7 0.31 11.0 7.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO17286.1 - 0.56 8.3 9.4 0.72 8.0 9.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 BSP_II PF05432.11 ETO17286.1 - 1.3 8.7 10.1 1.9 8.1 10.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PrmA PF06325.13 ETO17287.1 - 1.1e-11 44.7 0.3 2.3e-11 43.7 0.2 1.4 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ETO17287.1 - 2.1e-11 43.8 0.5 2.3e-08 33.9 0.0 2.3 1 1 0 2 2 2 2 Conserved hypothetical protein 95 MTS PF05175.14 ETO17287.1 - 5.4e-11 42.3 0.2 1e-07 31.7 0.1 2.3 2 0 0 2 2 2 2 Methyltransferase small domain Methyltransf_31 PF13847.6 ETO17287.1 - 2.3e-09 37.2 2.5 3.2e-09 36.8 1.3 1.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO17287.1 - 1.2e-07 32.3 0.4 9.1e-07 29.5 0.1 2.4 1 1 0 2 2 2 1 Methyltransferase domain Met_10 PF02475.16 ETO17287.1 - 2.5e-06 27.4 0.2 1.2e-05 25.1 0.0 1.9 2 0 0 2 2 2 1 Met-10+ like-protein Methyltransf_23 PF13489.6 ETO17287.1 - 9.6e-06 25.5 0.0 1.5e-05 24.9 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO17287.1 - 1.6e-05 24.9 0.8 3.6e-05 23.8 0.6 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ETO17287.1 - 5e-05 22.9 1.7 0.00015 21.4 1.7 1.9 1 1 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_3 PF01596.17 ETO17287.1 - 9.4e-05 21.7 0.1 0.00025 20.3 0.0 1.6 1 1 1 2 2 2 1 O-methyltransferase Methyltransf_11 PF08241.12 ETO17287.1 - 0.0002 22.0 0.1 0.0013 19.3 0.0 2.3 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO17287.1 - 0.00069 20.3 0.6 0.028 15.2 0.0 2.8 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 ETO17287.1 - 0.0018 18.3 0.9 0.0057 16.6 0.1 2.2 1 1 1 2 2 2 1 Methyltransferase domain DNA_methylase PF00145.17 ETO17287.1 - 0.0027 17.1 1.2 0.038 13.3 0.0 2.2 1 1 1 2 2 2 1 C-5 cytosine-specific DNA methylase PCMT PF01135.19 ETO17287.1 - 0.011 15.5 0.0 0.02 14.7 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_2 PF00891.18 ETO17287.1 - 0.012 14.9 0.1 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 O-methyltransferase domain AdoMet_MTase PF07757.13 ETO17287.1 - 0.016 15.5 0.0 0.071 13.5 0.0 2.0 2 0 0 2 2 2 0 Predicted AdoMet-dependent methyltransferase UPF0020 PF01170.18 ETO17287.1 - 0.018 14.8 0.7 1.1 8.9 0.7 2.9 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_9 PF08003.11 ETO17287.1 - 0.047 12.6 0.0 0.11 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_16 PF10294.9 ETO17287.1 - 0.087 12.5 1.6 0.25 11.1 0.2 2.2 2 1 0 2 2 2 0 Lysine methyltransferase FmrO PF07091.11 ETO17287.1 - 0.16 11.5 0.1 0.26 10.8 0.1 1.3 1 0 0 1 1 1 0 Ribosomal RNA methyltransferase (FmrO) UPF0184 PF03670.13 ETO17288.1 - 0.00026 21.3 3.0 0.021 15.2 0.5 2.7 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0184) RRP14 PF15459.6 ETO17288.1 - 6.3 7.5 8.1 19 5.9 8.1 1.7 1 0 0 1 1 1 0 60S ribosome biogenesis protein Rrp14 SNARE PF05739.19 ETO17289.1 - 0.0046 16.9 10.6 0.0047 16.9 7.2 2.2 2 0 0 2 2 2 1 SNARE domain RIFIN PF02009.16 ETO17289.1 - 0.014 15.4 4.1 0.016 15.1 4.1 1.0 1 0 0 1 1 1 0 Rifin Orf78 PF06024.12 ETO17289.1 - 0.016 15.5 1.0 0.02 15.2 1.0 1.2 1 0 0 1 1 1 0 Orf78 (ac78) LRRC37AB_C PF14914.6 ETO17289.1 - 0.035 14.0 3.8 0.045 13.7 3.8 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF983 PF06170.12 ETO17289.1 - 5.9 7.4 7.1 5.1 7.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF983) Lectin_leg-like PF03388.13 ETO17291.1 - 1.5e-14 53.9 1.2 1.1e-12 47.9 1.2 2.1 1 1 0 1 1 1 1 Legume-like lectin family Bact_lectin PF18483.1 ETO17291.1 - 0.0048 16.9 0.0 0.0065 16.5 0.0 1.1 1 0 0 1 1 1 1 Bacterial lectin VGPC1_C PF16799.5 ETO17292.1 - 0.011 15.7 0.4 0.025 14.6 0.4 1.6 1 0 0 1 1 1 0 C-terminal membrane-localisation domain of ion-channel, VCN1 DUF4834 PF16118.5 ETO17292.1 - 0.061 14.3 0.7 0.061 14.3 0.7 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SID-1_RNA_chan PF13965.6 ETO17292.1 - 1.3 7.4 5.7 0.12 10.7 0.8 1.6 1 1 0 2 2 2 0 dsRNA-gated channel SID-1 FmiP_Thoc5 PF09766.9 ETO17293.1 - 1e-26 94.1 1.2 1.5e-26 93.5 1.2 1.3 1 1 0 1 1 1 1 Fms-interacting protein/Thoc5 DUF3797 PF12677.7 ETO17294.1 - 0.0062 16.4 0.2 0.013 15.4 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3797) Ank_2 PF12796.7 ETO17295.1 - 0.00071 20.1 0.0 0.0012 19.3 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO17295.1 - 0.0012 19.1 0.0 0.2 12.0 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO17295.1 - 0.006 17.1 0.4 0.091 13.4 0.1 2.4 1 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO17295.1 - 0.02 15.4 0.1 1.8 9.4 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat SNAPc_SNAP43 PF09808.9 ETO17296.1 - 0.0081 16.1 0.1 0.0081 16.1 0.1 1.9 2 0 0 2 2 2 1 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 OrfB_IS605 PF01385.19 ETO17296.1 - 0.28 11.4 3.9 0.87 9.8 0.8 2.2 2 0 0 2 2 2 0 Probable transposase Ferlin_C PF16165.5 ETO17296.1 - 0.54 10.2 4.7 1.9 8.4 0.1 2.3 1 1 1 2 2 2 0 Ferlin C-terminus RRP14 PF15459.6 ETO17296.1 - 4.2 8.0 9.1 4.5 7.9 1.5 2.7 2 0 0 2 2 2 0 60S ribosome biogenesis protein Rrp14 PspA_IM30 PF04012.12 ETO17298.1 - 0.015 14.9 0.8 0.049 13.2 0.8 1.7 1 1 0 1 1 1 0 PspA/IM30 family ORF6N PF10543.9 ETO17298.1 - 0.095 12.9 0.5 0.19 12.0 0.2 1.7 2 0 0 2 2 2 0 ORF6N domain Wtap PF17098.5 ETO17298.1 - 0.27 11.2 4.4 0.17 11.8 2.0 1.8 2 0 0 2 2 2 0 WTAP/Mum2p family ComC PF03047.14 ETO17298.1 - 2.1 8.2 5.3 5.1 7.0 0.0 2.7 2 0 0 2 2 2 0 COMC family WD40 PF00400.32 ETO17299.1 - 7.4e-12 45.6 13.5 7.3e-05 23.5 0.1 4.8 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17299.1 - 1.3e-09 38.2 1.4 0.001 19.3 0.2 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17299.1 - 7.2e-05 21.9 2.6 0.017 14.1 0.0 2.4 3 0 0 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO17299.1 - 0.0046 16.9 4.1 1 9.4 0.1 2.8 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO17299.1 - 0.058 12.3 0.1 2.2 7.1 0.0 2.8 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF3054 PF11255.8 ETO17300.1 - 0.049 14.1 1.2 0.049 14.1 1.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3054) ABC2_membrane_2 PF12679.7 ETO17300.1 - 0.34 10.2 8.4 0.14 11.4 5.4 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein RGS PF00615.19 ETO17301.1 - 0.016 15.4 0.0 0.049 13.9 0.0 1.8 1 1 0 1 1 1 0 Regulator of G protein signaling domain WBS28 PF15164.6 ETO17301.1 - 0.023 14.0 0.7 0.1 11.9 0.0 2.2 2 1 1 3 3 3 0 Williams-Beuren syndrome chromosomal region 28 protein homologue Amidase_2 PF01510.25 ETO17302.1 - 0.099 13.1 0.7 0.15 12.5 0.7 1.5 1 1 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase Oxidored_FMN PF00724.20 ETO17303.1 - 9.6e-45 153.3 0.0 1.1e-44 153.1 0.0 1.0 1 0 0 1 1 1 1 NADH:flavin oxidoreductase / NADH oxidase family Dus PF01207.17 ETO17303.1 - 0.0086 15.2 0.0 0.25 10.4 0.0 2.2 1 1 1 2 2 2 2 Dihydrouridine synthase (Dus) Ceramidase PF05875.12 ETO17304.1 - 1.4e-14 54.2 13.3 6.7e-10 38.8 2.5 2.2 2 0 0 2 2 2 2 Ceramidase ZZ PF00569.17 ETO17305.1 - 0.011 15.5 4.5 0.011 15.5 4.5 1.9 2 0 0 2 2 2 0 Zinc finger, ZZ type DUF3385 PF11865.8 ETO17305.1 - 0.018 15.0 0.2 0.16 11.9 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF3385) C1_2 PF03107.16 ETO17305.1 - 0.12 12.7 9.1 0.45 10.9 9.1 2.1 1 1 0 1 1 1 0 C1 domain DZR PF12773.7 ETO17305.1 - 0.14 12.2 2.9 0.2 11.7 1.6 1.9 1 1 0 1 1 1 0 Double zinc ribbon Zn-ribbon_8 PF09723.10 ETO17305.1 - 2.9 8.1 5.6 4.7 7.4 0.0 2.7 2 1 0 2 2 2 0 Zinc ribbon domain MMR_HSR1 PF01926.23 ETO17306.1 - 4.8e-05 23.4 1.6 0.00016 21.7 0.3 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO17306.1 - 0.004 16.7 0.5 0.066 12.8 0.0 2.7 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO17306.1 - 0.0067 16.3 1.6 0.0067 16.3 1.6 3.1 3 1 0 3 3 3 1 RsgA GTPase ABC_tran PF00005.27 ETO17306.1 - 0.021 15.4 0.1 0.021 15.4 0.1 3.0 4 1 0 4 4 4 0 ABC transporter DnaB_2 PF07261.11 ETO17306.1 - 0.05 13.4 0.9 1.9 8.3 0.0 3.5 3 0 0 3 3 3 0 Replication initiation and membrane attachment TPR_MLP1_2 PF07926.12 ETO17306.1 - 0.052 13.6 18.7 0.022 14.8 2.4 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4272 PF14094.6 ETO17306.1 - 0.053 12.8 0.7 0.097 11.9 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4272) DUF2203 PF09969.9 ETO17306.1 - 0.2 12.4 8.1 2 9.1 0.4 3.6 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) Glutaredoxin2_C PF04399.13 ETO17306.1 - 0.31 10.9 4.5 1.5 8.6 0.2 2.8 2 0 0 2 2 2 0 Glutaredoxin 2, C terminal domain PduV-EutP PF10662.9 ETO17306.1 - 0.31 10.8 5.2 17 5.1 0.0 4.1 4 0 0 4 4 4 0 Ethanolamine utilisation - propanediol utilisation SAM_KSR1 PF13543.6 ETO17306.1 - 0.55 10.4 13.6 0.027 14.6 2.1 3.9 3 1 1 4 4 4 0 SAM like domain present in kinase suppressor RAS 1 Tyrosinase PF00264.20 ETO17306.1 - 1.1 9.6 2.9 0.74 10.1 0.1 2.1 2 1 0 2 2 2 0 Common central domain of tyrosinase SKA2 PF16740.5 ETO17306.1 - 9.3 6.1 22.7 0.035 13.9 2.1 4.2 4 1 0 4 4 4 0 Spindle and kinetochore-associated protein 2 FHA PF00498.26 ETO17307.1 - 8e-16 58.2 0.0 3.5e-15 56.1 0.0 2.2 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ETO17307.1 - 5e-09 36.4 0.1 9.3e-05 22.7 0.1 2.7 1 1 1 2 2 2 2 Inner membrane component of T3SS, cytoplasmic domain SET PF00856.28 ETO17307.1 - 0.038 14.4 3.4 0.43 10.9 0.8 2.2 2 0 0 2 2 2 0 SET domain LAP1C PF05609.12 ETO17307.1 - 0.18 10.9 10.1 1.9 7.5 0.1 2.3 2 1 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) FAM176 PF14851.6 ETO17307.1 - 0.34 10.6 4.5 4.7 6.9 2.7 2.4 2 0 0 2 2 2 0 FAM176 family DUF3464 PF11947.8 ETO17307.1 - 1.6 8.4 11.8 3 7.6 0.0 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 ORC_WH_C PF18137.1 ETO17307.1 - 2.9 8.0 9.0 13 5.9 6.1 2.4 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal MgsA_C PF12002.8 ETO17308.1 - 2e-65 219.8 0.0 2.8e-65 219.3 0.0 1.2 1 0 0 1 1 1 1 MgsA AAA+ ATPase C terminal AAA_assoc_2 PF16193.5 ETO17308.1 - 1.6e-18 66.8 0.0 3.9e-18 65.5 0.0 1.6 1 0 0 1 1 1 1 AAA C-terminal domain AAA PF00004.29 ETO17308.1 - 7.7e-18 65.2 0.0 1.2e-17 64.5 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO17308.1 - 6.9e-12 45.4 0.0 1.1e-11 44.7 0.0 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO17308.1 - 7.2e-07 29.3 0.1 1.1e-05 25.4 0.1 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO17308.1 - 1.4e-05 25.4 0.3 0.01 16.1 0.0 2.7 1 1 1 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO17308.1 - 1.7e-05 25.2 0.1 0.0028 18.1 0.0 2.6 1 1 1 2 2 2 1 AAA ATPase domain AAA_18 PF13238.6 ETO17308.1 - 6e-05 23.6 0.0 0.00013 22.5 0.0 1.7 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETO17308.1 - 6.8e-05 22.3 0.1 0.022 14.2 0.0 2.3 1 1 1 2 2 2 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 ETO17308.1 - 0.00013 22.0 0.0 0.00025 21.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_14 PF13173.6 ETO17308.1 - 0.00036 20.6 0.0 0.0011 19.0 0.0 1.8 2 0 0 2 2 1 1 AAA domain Sigma54_activat PF00158.26 ETO17308.1 - 0.00052 19.8 0.0 0.077 12.7 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain AAA_30 PF13604.6 ETO17308.1 - 0.00087 19.1 0.0 0.1 12.3 0.0 2.2 1 1 0 1 1 1 1 AAA domain SKI PF01202.22 ETO17308.1 - 0.0009 19.4 0.0 0.002 18.3 0.0 1.6 1 0 0 1 1 1 1 Shikimate kinase ResIII PF04851.15 ETO17308.1 - 0.0011 19.0 0.1 0.13 12.3 0.1 2.3 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit TsaE PF02367.17 ETO17308.1 - 0.0016 18.5 0.0 0.003 17.5 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_17 PF13207.6 ETO17308.1 - 0.0016 18.9 0.0 0.0034 17.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO17308.1 - 0.0019 18.6 0.0 0.0044 17.4 0.0 1.6 1 0 0 1 1 1 1 RNA helicase ATPase_2 PF01637.18 ETO17308.1 - 0.0021 18.0 0.0 0.091 12.7 0.0 2.4 1 1 1 2 2 2 1 ATPase domain predominantly from Archaea Sigma54_activ_2 PF14532.6 ETO17308.1 - 0.0023 18.1 0.0 0.0053 16.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain TIP49 PF06068.13 ETO17308.1 - 0.0026 17.0 0.0 0.0041 16.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain DNA_pol3_delta2 PF13177.6 ETO17308.1 - 0.0039 17.0 0.0 0.19 11.5 0.0 2.2 1 1 1 2 2 2 1 DNA polymerase III, delta subunit AAA_3 PF07726.11 ETO17308.1 - 0.0053 16.6 0.0 0.015 15.2 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_19 PF13245.6 ETO17308.1 - 0.008 16.5 0.1 2.3 8.6 0.1 2.3 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 ETO17308.1 - 0.0097 16.2 0.0 0.017 15.4 0.0 1.4 1 0 0 1 1 1 1 AAA domain Cytidylate_kin2 PF13189.6 ETO17308.1 - 0.0099 16.0 0.0 0.017 15.3 0.0 1.5 1 0 0 1 1 1 1 Cytidylate kinase-like family AAA_33 PF13671.6 ETO17308.1 - 0.01 16.0 0.0 0.02 15.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO17308.1 - 0.011 16.2 0.0 0.02 15.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 ETO17308.1 - 0.017 14.3 0.0 0.028 13.6 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain TniB PF05621.11 ETO17308.1 - 0.017 14.5 0.3 2.7 7.4 0.0 2.6 1 1 1 3 3 3 0 Bacterial TniB protein Cytidylate_kin PF02224.18 ETO17308.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 Cytidylate kinase AAA_2 PF07724.14 ETO17308.1 - 0.024 14.7 0.0 0.082 13.0 0.0 1.9 2 0 0 2 2 1 0 AAA domain (Cdc48 subfamily) Viral_helicase1 PF01443.18 ETO17308.1 - 0.057 13.2 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_24 PF13479.6 ETO17308.1 - 0.063 13.0 0.1 0.17 11.6 0.1 1.8 1 1 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ETO17308.1 - 0.066 12.5 0.0 0.1 11.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin IstB_IS21 PF01695.17 ETO17308.1 - 0.091 12.5 0.0 0.23 11.2 0.0 1.6 2 0 0 2 2 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 ETO17308.1 - 0.098 12.2 0.0 0.23 11.0 0.0 1.5 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_25 PF13481.6 ETO17308.1 - 0.13 11.8 0.0 0.35 10.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ETO17308.1 - 0.21 11.1 0.0 17 4.9 0.0 2.7 2 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain NTPase_1 PF03266.15 ETO17308.1 - 0.22 11.4 0.1 0.46 10.4 0.1 1.6 1 1 0 1 1 1 0 NTPase Fic PF02661.18 ETO17309.1 - 1.3e-13 51.7 0.1 5e-13 49.8 0.0 2.1 2 0 0 2 2 2 1 Fic/DOC family C5-epim_C PF06662.13 ETO17309.1 - 0.02 14.4 0.1 0.15 11.6 0.0 2.0 2 0 0 2 2 2 0 D-glucuronyl C5-epimerase C-terminus ASFV_J13L PF05568.11 ETO17310.1 - 0.096 12.4 0.1 0.16 11.7 0.1 1.3 1 0 0 1 1 1 0 African swine fever virus J13L protein WD40 PF00400.32 ETO17311.1 - 1.3e-38 130.3 19.1 8.6e-11 42.2 0.5 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17311.1 - 3.2e-16 59.4 2.8 0.0091 16.3 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO17311.1 - 6.5e-10 39.2 0.2 8.2e-06 25.8 0.0 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO17311.1 - 2.1e-09 36.8 0.1 0.042 12.8 0.0 4.2 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO17311.1 - 3.1e-07 30.0 0.3 0.014 14.7 0.1 2.4 2 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO17311.1 - 5.5e-07 28.6 3.6 0.85 8.2 0.1 4.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO17311.1 - 0.0007 18.2 0.1 0.019 13.5 0.0 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO17311.1 - 0.0015 18.4 1.2 75 3.4 0.0 5.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO17311.1 - 0.0038 17.3 1.3 14 5.8 0.0 4.2 2 2 4 6 6 6 1 Family of unknown function (DUF5570) DUF1513 PF07433.11 ETO17311.1 - 0.016 14.3 0.0 13 4.8 0.0 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1513) Nbas_N PF15492.6 ETO17311.1 - 0.068 12.5 2.5 3.7 6.8 0.1 3.5 2 2 2 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Resistin PF06954.11 ETO17311.1 - 0.096 13.2 1.2 12 6.6 0.1 3.5 3 1 1 4 4 4 0 Resistin TPR_12 PF13424.6 ETO17312.1 - 4.9e-97 318.3 23.1 7.3e-15 55.0 0.1 9.1 5 2 5 10 10 10 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17312.1 - 6.8e-62 203.8 0.0 3.7e-06 26.6 0.1 14.0 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17312.1 - 6.4e-60 196.7 71.3 2.7e-07 30.1 0.2 13.3 13 0 0 13 13 13 12 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17312.1 - 1.5e-59 193.3 69.8 4.8e-07 29.5 0.3 13.5 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17312.1 - 4.5e-55 179.4 49.8 1e-05 25.2 0.0 12.9 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17312.1 - 5.2e-53 173.3 18.4 5.7e-05 22.9 0.0 14.0 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17312.1 - 7.5e-19 66.8 0.0 0.63 11.0 0.0 11.0 11 1 1 12 12 11 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17312.1 - 2.9e-13 50.2 0.2 0.7 10.6 0.0 8.9 8 3 2 10 10 10 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17312.1 - 5.7e-12 45.1 22.3 1.1 9.7 0.0 12.5 13 0 0 13 13 11 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17312.1 - 3.7e-11 42.5 41.4 0.021 14.5 0.3 11.7 11 2 1 12 12 12 5 TPR repeat TPR_6 PF13174.6 ETO17312.1 - 5.7e-11 42.3 31.3 0.61 10.9 0.0 11.7 12 0 0 12 12 12 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17312.1 - 1.3e-06 28.5 25.7 0.065 13.5 0.8 6.2 6 0 0 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETO17312.1 - 3.7e-05 23.3 0.0 3.2 7.0 0.0 4.0 3 1 0 4 4 4 2 MalT-like TPR region TPR_19 PF14559.6 ETO17312.1 - 8.2e-05 23.0 8.3 0.61 10.6 0.0 5.9 7 0 0 7 7 5 2 Tetratricopeptide repeat SPO22 PF08631.10 ETO17312.1 - 0.00019 21.1 11.6 4.7 6.6 0.0 5.6 5 1 0 5 5 5 3 Meiosis protein SPO22/ZIP4 like DUF4810 PF16068.5 ETO17312.1 - 0.00039 20.9 0.8 5.8 7.5 0.0 4.8 4 0 0 4 4 4 1 Domain of unknown function (DUF4810) SHNi-TPR PF10516.9 ETO17312.1 - 0.0016 17.9 1.1 0.89 9.1 0.0 4.9 6 0 0 6 6 5 1 SHNi-TPR MIT PF04212.18 ETO17312.1 - 0.0026 17.8 38.0 3.7 7.7 0.0 11.1 9 1 3 12 12 12 1 MIT (microtubule interacting and transport) domain Kelch_5 PF13854.6 ETO17312.1 - 0.0073 16.3 0.4 0.77 9.8 0.0 3.3 2 0 0 2 2 2 1 Kelch motif DUF627 PF04781.12 ETO17312.1 - 0.0087 16.1 5.4 39 4.3 0.1 6.0 5 2 1 6 6 5 0 Protein of unknown function (DUF627) DUF5113 PF17140.4 ETO17312.1 - 0.011 15.5 42.0 1 9.2 0.1 10.1 9 2 2 11 11 11 0 Domain of unknown function (DUF5113) Kelch_6 PF13964.6 ETO17312.1 - 0.015 15.6 9.1 2.5 8.5 0.2 5.3 5 0 0 5 5 5 0 Kelch motif Sel1 PF08238.12 ETO17312.1 - 0.23 12.2 31.2 13 6.6 1.0 8.8 10 0 0 10 10 9 0 Sel1 repeat DUF5105 PF17118.5 ETO17312.1 - 1.6 8.4 13.3 0.1 12.4 0.5 4.3 3 2 1 4 4 4 0 Domain of unknown function (DUF5105) zf-TRAF PF02176.18 ETO17313.1 - 7.4e-05 23.4 0.7 7.4e-05 23.4 0.7 2.9 2 0 0 2 2 2 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETO17313.1 - 0.26 11.2 7.9 0.21 11.5 4.9 2.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO17313.1 - 0.34 10.8 4.7 6.3 6.8 4.7 2.9 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WHEP-TRS PF00458.20 ETO17313.1 - 0.93 9.7 8.1 0.076 13.2 1.8 2.3 2 0 0 2 2 2 0 WHEP-TRS domain CSG2 PF16965.5 ETO17314.1 - 0.017 14.1 0.1 0.022 13.7 0.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator CSD PF00313.22 ETO17315.1 - 3.7e-07 29.9 0.1 0.3 11.0 0.0 3.2 3 0 0 3 3 3 3 'Cold-shock' DNA-binding domain DUF3637 PF12337.8 ETO17315.1 - 0.06 13.7 0.0 0.18 12.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3637) DUF4062 PF13271.6 ETO17316.1 - 0.11 12.8 0.6 0.26 11.7 0.2 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4062) TA0956 PF11513.8 ETO17316.1 - 0.15 12.3 1.0 0.26 11.5 0.5 1.7 2 1 0 2 2 2 0 Thermoplasma acidophilum protein TA0956 FliL PF03748.14 ETO17316.1 - 2.3 8.9 12.0 1.1 9.8 1.2 3.1 1 1 1 2 2 2 0 Flagellar basal body-associated protein FliL PepSY PF03413.19 ETO17316.1 - 5.9 7.5 6.9 4.5 7.9 0.2 2.8 2 1 1 3 3 3 0 Peptidase propeptide and YPEB domain FH2 PF02181.23 ETO17317.1 - 1.5e-36 126.4 0.0 1.7e-36 126.1 0.0 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain NES_C_h PF18208.1 ETO17317.1 - 0.079 13.2 0.5 0.12 12.6 0.5 1.2 1 0 0 1 1 1 0 Nicking enzyme C-terminal middle helical domain DHR-2 PF06920.13 ETO17318.1 - 2.1e-43 148.8 10.1 1.3e-41 142.9 10.1 2.6 1 1 0 1 1 1 1 Dock homology region 2 DOCK-C2 PF14429.6 ETO17318.1 - 8.4e-22 77.9 0.1 2e-21 76.7 0.1 1.6 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 ETO17318.1 - 1e-13 51.0 0.6 4.5e-13 48.9 0.1 2.2 2 1 0 2 2 2 1 DOCK N-terminus PSY3 PF16836.5 ETO17318.1 - 0.026 14.0 0.1 0.074 12.6 0.1 1.7 1 0 0 1 1 1 0 Shu complex component Psy3, DNA-binding description DUF4795 PF16043.5 ETO17318.1 - 0.4 10.3 4.4 15 5.1 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4795) Zeta_toxin PF06414.12 ETO17320.1 - 0.0092 15.3 0.0 0.018 14.3 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 ETO17320.1 - 0.012 16.0 0.0 0.029 14.7 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF2951 PF11166.8 ETO17320.1 - 0.11 12.8 6.5 0.9 9.8 0.8 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) Ant_C PF05586.11 ETO17321.1 - 0.0062 17.1 0.2 0.0062 17.1 0.2 3.0 2 1 1 3 3 3 1 Anthrax receptor C-terminus region Pkinase PF00069.25 ETO17322.1 - 1.7e-17 63.6 2.1 8.1e-17 61.5 0.1 2.9 2 1 0 2 2 2 1 Protein kinase domain DUF262 PF03235.14 ETO17324.1 - 1 9.5 12.9 1.3 9.1 12.9 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 DUF4407 PF14362.6 ETO17324.1 - 2.7 7.2 7.2 3.1 7.1 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RabGAP-TBC PF00566.18 ETO17325.1 - 9.2e-06 25.5 0.1 1.6e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AJAP1_PANP_C PF15298.6 ETO17325.1 - 7.5 6.7 30.3 2.5 8.3 7.5 2.6 3 0 0 3 3 3 0 AJAP1/PANP C-terminus Dicty_REP PF05086.12 ETO17325.1 - 7.9 4.3 18.7 1.9 6.3 8.1 2.2 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Glyco_transf_7C PF02709.14 ETO17326.1 - 0.1 12.3 0.3 0.25 11.1 0.3 1.7 1 0 0 1 1 1 0 N-terminal domain of galactosyltransferase Presenilin PF01080.17 ETO17327.1 - 0.0044 15.9 3.6 0.0059 15.4 3.6 1.2 1 0 0 1 1 1 1 Presenilin SDA1 PF05285.12 ETO17327.1 - 0.053 12.9 25.8 0.078 12.4 25.8 1.2 1 0 0 1 1 1 0 SDA1 DDHD PF02862.17 ETO17327.1 - 0.059 13.5 0.4 0.091 12.9 0.4 1.4 1 0 0 1 1 1 0 DDHD domain Nop14 PF04147.12 ETO17327.1 - 0.27 9.4 28.0 0.36 9.0 28.0 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO17327.1 - 3.2 7.0 23.3 4.7 6.5 23.3 1.2 1 0 0 1 1 1 0 BUD22 DUF913 PF06025.12 ETO17327.1 - 5.7 5.8 8.2 10 5.0 8.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ABC2_membrane_3 PF12698.7 ETO17328.1 - 0.00047 19.4 0.0 0.00054 19.2 0.0 1.1 1 0 0 1 1 1 1 ABC-2 family transporter protein Neugrin PF06413.11 ETO17328.1 - 0.038 14.0 3.3 0.05 13.6 3.3 1.1 1 0 0 1 1 1 0 Neugrin CreD PF06123.12 ETO17328.1 - 0.065 12.0 2.8 0.072 11.9 2.8 1.4 1 1 0 1 1 1 0 Inner membrane protein CreD Cullin PF00888.22 ETO17329.1 - 6.6e-13 48.1 9.7 3.9e-07 29.1 1.1 2.9 3 0 0 3 3 3 2 Cullin family ANAPC2 PF08672.11 ETO17329.1 - 0.0002 21.8 0.1 0.00048 20.6 0.1 1.7 1 0 0 1 1 1 1 Anaphase promoting complex (APC) subunit 2 Phage-A118_gp45 PF10653.9 ETO17329.1 - 0.008 16.2 1.1 0.012 15.6 0.0 1.8 2 0 0 2 2 2 1 Protein gp45 of Bacteriophage A118 SpoIIIAH PF12685.7 ETO17329.1 - 0.9 9.3 9.8 0.13 12.1 1.4 2.4 2 0 0 2 2 2 0 SpoIIIAH-like protein Vfa1 PF08432.10 ETO17329.1 - 1.8 8.9 12.8 1.7 8.9 6.6 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 FAM176 PF14851.6 ETO17329.1 - 7.4 6.2 11.4 1.6 8.4 2.8 2.7 2 0 0 2 2 2 0 FAM176 family CDC45 PF02724.14 ETO17329.1 - 8.2 4.6 18.5 0.063 11.6 8.8 2.0 2 0 0 2 2 2 0 CDC45-like protein ParcG PF10274.9 ETO17330.1 - 1.7e-50 171.7 0.0 2.3e-50 171.2 0.0 1.2 1 0 0 1 1 1 1 Parkin co-regulated protein CPSF100_C PF13299.6 ETO17331.1 - 0.0016 18.6 5.0 0.2 11.8 2.0 2.1 2 0 0 2 2 2 2 Cleavage and polyadenylation factor 2 C-terminal DUF2201_N PF13203.6 ETO17331.1 - 0.0097 15.5 0.6 0.073 12.7 0.2 2.0 2 0 0 2 2 2 1 Putative metallopeptidase domain Tyrosinase PF00264.20 ETO17331.1 - 0.011 16.1 0.9 0.011 16.1 0.9 1.6 2 0 0 2 2 2 0 Common central domain of tyrosinase Zip PF02535.22 ETO17331.1 - 0.025 13.8 3.3 0.036 13.3 0.2 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4820 PF16091.5 ETO17331.1 - 0.12 11.8 9.7 1.1 8.5 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Neur_chan_memb PF02932.16 ETO17331.1 - 0.45 10.5 3.8 2.8 8.0 0.9 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Connexin PF00029.19 ETO17331.1 - 0.61 9.8 5.6 1.9 8.2 0.1 2.2 2 0 0 2 2 2 0 Connexin Cyclin_C PF02984.19 ETO17331.1 - 0.71 10.0 0.0 0.71 10.0 0.0 3.2 3 1 1 4 4 3 0 Cyclin, C-terminal domain CSG2 PF16965.5 ETO17331.1 - 1.6 7.6 5.9 1.5 7.7 0.2 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator CLN3 PF02487.17 ETO17331.1 - 3.9 6.4 5.2 13 4.7 0.0 2.1 2 0 0 2 2 2 0 CLN3 protein V_ATPase_I PF01496.19 ETO17331.1 - 4.9 4.9 9.7 6.6 4.5 5.2 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF913 PF06025.12 ETO17332.1 - 0.12 11.3 0.8 0.15 11.0 0.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) LPP PF04728.13 ETO17332.1 - 0.38 11.2 2.9 0.68 10.4 2.9 1.4 1 0 0 1 1 1 0 Lipoprotein leucine-zipper FH2 PF02181.23 ETO17333.1 - 4.6e-49 167.5 0.1 5.5e-49 167.3 0.1 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain DUF4886 PF16227.5 ETO17333.1 - 0.16 11.1 0.0 0.3 10.2 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4886) XK-related PF09815.9 ETO17334.1 - 1.3e-07 31.0 18.4 2.2e-06 27.0 18.7 2.0 1 1 0 1 1 1 1 XK-related protein WD40 PF00400.32 ETO17335.1 - 5.7e-35 118.8 7.2 2.4e-06 28.2 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17335.1 - 3.1e-23 81.9 0.7 5.6e-05 23.4 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO17335.1 - 2.3e-10 40.3 6.0 0.0016 17.8 0.1 3.0 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO17335.1 - 1.6e-07 30.6 1.2 0.0043 16.1 0.1 4.4 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO17335.1 - 1.7e-06 27.8 0.7 0.71 9.9 0.0 4.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO17335.1 - 1.6e-05 23.8 4.3 2.7 6.6 0.0 4.5 2 2 2 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO17335.1 - 0.0022 16.6 0.2 0.15 10.5 0.0 2.5 1 1 1 3 3 3 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO17335.1 - 0.016 15.1 0.0 19 5.4 0.0 4.5 6 0 0 6 6 6 0 PQQ enzyme repeat DPPIV_N PF00930.21 ETO17335.1 - 0.017 13.9 0.1 13 4.4 0.0 3.5 3 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5474 PF17568.2 ETO17335.1 - 0.037 14.1 1.8 8.4 6.5 0.2 3.1 3 0 0 3 3 3 0 Family of unknown function (DUF5474) Proteasome_A_N PF10584.9 ETO17335.1 - 0.14 11.9 4.5 22 4.8 0.2 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Kelch_5 PF13854.6 ETO17336.1 - 6.1e-05 22.9 1.6 0.019 14.9 0.4 4.3 4 0 0 4 4 4 1 Kelch motif Calici_PP_N PF08405.11 ETO17336.1 - 0.00055 18.9 0.0 0.00093 18.1 0.0 1.3 1 0 0 1 1 1 1 Viral polyprotein N-terminal Kelch_1 PF01344.25 ETO17336.1 - 0.0023 17.5 2.6 0.7 9.5 0.2 3.6 4 0 0 4 4 4 2 Kelch motif Ras PF00071.22 ETO17337.1 - 0.00037 20.1 0.0 0.00068 19.3 0.0 1.5 1 0 0 1 1 1 1 Ras family FKBP_C PF00254.28 ETO17338.1 - 1.6e-12 47.5 0.0 8.8e-12 45.2 0.0 2.1 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase CBP4 PF07960.11 ETO17339.1 - 0.059 13.2 3.8 0.082 12.8 3.8 1.2 1 0 0 1 1 1 0 CBP4 ArfGap PF01412.18 ETO17340.1 - 1.7e-08 34.5 0.0 1.7e-08 34.5 0.0 2.0 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf PH PF00169.29 ETO17340.1 - 0.017 15.6 0.2 0.053 14.0 0.1 1.8 1 1 0 1 1 1 0 PH domain PH_11 PF15413.6 ETO17340.1 - 0.15 12.5 0.3 0.15 12.5 0.3 1.9 2 0 0 2 2 2 0 Pleckstrin homology domain MT0933_antitox PF14013.6 ETO17342.1 - 0.17 12.2 3.2 0.3 11.4 3.2 1.4 1 0 0 1 1 1 0 MT0933-like antitoxin protein Senescence PF06911.12 ETO17342.1 - 0.23 11.8 0.0 0.34 11.2 0.0 1.3 1 0 0 1 1 1 0 Senescence-associated protein CAP_GLY PF01302.25 ETO17343.1 - 1.1e-10 41.4 3.2 0.00011 22.2 0.0 2.6 3 1 0 3 3 3 2 CAP-Gly domain cNMP_binding PF00027.29 ETO17344.1 - 1.8e-45 152.9 1.9 1e-16 60.7 0.0 5.2 4 1 0 4 4 4 4 Cyclic nucleotide-binding domain FlaC_arch PF05377.11 ETO17345.1 - 0.036 14.5 2.3 0.077 13.4 2.3 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) MscS_TM PF12794.7 ETO17345.1 - 1.4 7.7 6.2 3.5 6.4 0.0 2.1 2 0 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 CAP_N PF01213.19 ETO17347.1 - 0.011 15.2 1.1 0.018 14.6 1.1 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 ETO17347.1 - 0.13 12.3 1.0 0.24 11.4 1.0 1.5 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 ETO17347.1 - 1.3 9.1 7.6 2.5 8.2 7.6 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Sec10 PF07393.11 ETO17349.1 - 8.5e-23 80.7 1.2 9.2e-23 80.6 1.2 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec10 DUF832 PF05734.11 ETO17349.1 - 0.069 12.6 0.2 0.09 12.2 0.2 1.2 1 0 0 1 1 1 0 Herpesvirus protein of unknown function (DUF832) CorA PF01544.18 ETO17349.1 - 0.07 12.4 0.8 1 8.6 0.0 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein TPR_12 PF13424.6 ETO17350.1 - 6.6e-07 29.5 3.1 0.0065 16.7 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17350.1 - 4e-06 26.5 7.8 0.007 16.4 0.2 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat Zip PF02535.22 ETO17350.1 - 5.7e-05 22.5 16.7 7.2e-05 22.2 16.7 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter TPR_1 PF00515.28 ETO17350.1 - 6.6e-05 22.6 7.3 0.062 13.2 0.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat DDHD PF02862.17 ETO17350.1 - 0.0012 19.1 4.4 0.0019 18.4 4.4 1.3 1 0 0 1 1 1 1 DDHD domain TPR_7 PF13176.6 ETO17350.1 - 0.0017 18.2 1.0 0.94 9.7 0.3 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3410 PF11890.8 ETO17350.1 - 0.03 14.1 0.7 0.064 13.1 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3410) FAM76 PF16046.5 ETO17350.1 - 0.031 13.6 9.6 0.04 13.3 9.6 1.4 1 0 0 1 1 1 0 FAM76 protein Raftlin PF15250.6 ETO17350.1 - 0.043 12.6 8.7 0.054 12.2 8.7 1.1 1 0 0 1 1 1 0 Raftlin AF-4 PF05110.13 ETO17350.1 - 0.065 11.3 15.1 0.082 11.0 15.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF5523 PF17661.1 ETO17350.1 - 0.076 12.7 10.7 0.15 11.7 10.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5523) NPR3 PF03666.13 ETO17350.1 - 0.11 11.3 9.4 0.14 11.0 9.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO17350.1 - 0.14 10.9 15.0 0.19 10.5 15.0 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO17350.1 - 0.14 10.4 11.6 0.15 10.3 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Dynactin_p62 PF05502.13 ETO17350.1 - 0.21 10.3 7.1 0.35 9.6 7.1 1.3 1 0 0 1 1 1 0 Dynactin p62 family MIT PF04212.18 ETO17350.1 - 0.22 11.6 1.7 0.5 10.5 0.2 2.3 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain PNISR PF15996.5 ETO17350.1 - 0.29 11.4 15.9 0.5 10.6 15.9 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Trypan_PARP PF05887.11 ETO17350.1 - 0.48 10.4 8.2 0.8 9.7 8.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CLN3 PF02487.17 ETO17350.1 - 0.5 9.4 2.5 0.61 9.1 2.5 1.3 1 0 0 1 1 1 0 CLN3 protein DUF4045 PF13254.6 ETO17350.1 - 0.54 9.9 10.0 0.71 9.5 10.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) Endostatin PF06482.11 ETO17350.1 - 0.54 9.7 13.1 0.8 9.1 13.1 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Pex14_N PF04695.13 ETO17350.1 - 0.68 10.6 3.3 1.2 9.8 3.3 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Tim54 PF11711.8 ETO17350.1 - 0.72 8.6 10.1 0.33 9.7 8.1 1.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Connexin PF00029.19 ETO17350.1 - 1.1 8.9 8.5 2.4 7.9 8.5 1.7 1 0 0 1 1 1 0 Connexin SLC12 PF03522.15 ETO17350.1 - 1.2 8.0 10.4 1.7 7.6 10.4 1.2 1 0 0 1 1 1 0 Solute carrier family 12 DDRGK PF09756.9 ETO17350.1 - 1.8 8.1 16.9 3 7.4 16.9 1.4 1 0 0 1 1 1 0 DDRGK domain ALMT PF11744.8 ETO17350.1 - 1.9 7.2 10.9 2.9 6.6 10.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Otopetrin PF03189.13 ETO17350.1 - 2.3 6.9 6.0 2.6 6.8 6.0 1.2 1 0 0 1 1 1 0 Otopetrin Neur_chan_memb PF02932.16 ETO17350.1 - 3.3 7.7 8.8 5.9 6.9 8.8 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMEM119 PF15724.5 ETO17350.1 - 4.3 7.3 7.5 6.2 6.8 7.5 1.1 1 0 0 1 1 1 0 TMEM119 family RP-C_C PF11800.8 ETO17350.1 - 5.5 7.0 9.6 9.6 6.2 9.6 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region TPR_8 PF13181.6 ETO17350.1 - 7.2 7.1 7.2 10 6.6 0.0 3.4 4 0 0 4 4 3 0 Tetratricopeptide repeat Sec62 PF03839.16 ETO17350.1 - 9.3 5.7 9.7 14 5.1 9.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 BORG_CEP PF14957.6 ETO17350.1 - 9.4 7.4 11.1 20 6.4 11.1 1.6 1 0 0 1 1 1 0 Cdc42 effector TPR_8 PF13181.6 ETO17351.1 - 9.2e-07 28.6 0.2 0.00052 20.0 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17351.1 - 1.1e-06 29.0 0.9 2.2e-06 28.0 0.4 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17351.1 - 2.1e-06 27.3 7.2 6.6e-06 25.7 0.1 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17351.1 - 3.7e-06 26.6 3.6 3.6e-05 23.5 0.1 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17351.1 - 4e-05 24.1 0.8 0.23 12.4 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17351.1 - 0.008 16.8 0.7 1.7 9.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17351.1 - 0.086 13.1 0.6 0.086 13.1 0.6 3.1 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17351.1 - 0.15 12.7 0.3 0.29 11.8 0.3 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17351.1 - 0.78 10.0 8.3 0.96 9.7 5.3 2.6 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.32 ETO17352.1 - 0.017 16.0 2.9 0.1 13.5 2.9 2.5 1 0 0 1 1 1 0 WD domain, G-beta repeat MgsA_C PF12002.8 ETO17352.1 - 2.3 8.1 6.0 7.3 6.5 6.0 1.8 1 0 0 1 1 1 0 MgsA AAA+ ATPase C terminal RRN3 PF05327.11 ETO17352.1 - 3.7 6.0 13.0 0.9 8.0 9.7 1.5 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 IMUP PF15761.5 ETO17352.1 - 6.2 7.6 12.7 49 4.7 12.8 2.3 2 0 0 2 2 2 0 Immortalisation up-regulated protein Helicase_C PF00271.31 ETO17353.1 - 2.2e-32 111.7 0.0 3.9e-32 110.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO17353.1 - 1.4e-15 57.5 0.0 1.2e-14 54.5 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-CCHC PF00098.23 ETO17353.1 - 0.0048 16.9 1.4 0.0048 16.9 1.4 2.0 2 0 0 2 2 2 1 Zinc knuckle Helicase_C_2 PF13307.6 ETO17353.1 - 0.021 15.0 0.0 0.036 14.2 0.0 1.4 1 0 0 1 1 1 0 Helicase C-terminal domain zf-CCHC_4 PF14392.6 ETO17353.1 - 0.17 11.7 0.3 0.31 10.8 0.3 1.5 1 0 0 1 1 1 0 Zinc knuckle SAM_1 PF00536.30 ETO17354.1 - 0.0046 17.4 1.1 13 6.4 0.0 3.6 4 0 0 4 4 4 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO17354.1 - 0.017 15.2 0.6 8 6.7 0.0 3.4 4 0 0 4 4 4 0 SAM domain (Sterile alpha motif) Draxin PF15550.6 ETO17354.1 - 0.17 11.8 1.6 0.23 11.3 1.6 1.1 1 0 0 1 1 1 0 Draxin PG_binding_2 PF08823.11 ETO17354.1 - 0.17 12.2 1.5 2.9 8.3 0.1 3.6 4 1 0 4 4 4 0 Putative peptidoglycan binding domain TINF2_N PF14973.6 ETO17354.1 - 3.3 8.0 6.5 1.3 9.4 1.4 2.4 2 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus T6PP_N PF18572.1 ETO17354.1 - 4.1 7.3 10.6 1.6 8.6 6.4 2.5 2 1 1 3 3 3 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain GvpK PF05121.12 ETO17355.1 - 0.13 12.4 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Gas vesicle protein K U-box PF04564.15 ETO17356.1 - 9.8e-13 48.1 0.1 1.8e-12 47.2 0.1 1.5 1 0 0 1 1 1 1 U-box domain TPR_12 PF13424.6 ETO17357.1 - 0.00021 21.5 0.0 0.0004 20.6 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17357.1 - 0.0013 18.6 0.0 0.0035 17.2 0.0 1.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17357.1 - 0.0032 17.5 0.0 0.0081 16.2 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17357.1 - 0.021 15.0 0.2 0.07 13.4 0.2 2.0 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17357.1 - 0.031 14.1 0.1 0.09 12.6 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat s48_45 PF07422.13 ETO17357.1 - 0.065 13.8 6.2 0.078 13.5 5.7 1.5 1 1 0 1 1 1 0 Sexual stage antigen s48/45 domain FliS PF02561.14 ETO17357.1 - 0.069 13.4 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Flagellar protein FliS Sec7 PF01369.20 ETO17358.1 - 2.3e-52 177.3 8.0 3.1e-52 176.9 6.2 2.1 1 1 1 2 2 2 1 Sec7 domain DUF1981 PF09324.10 ETO17358.1 - 7.2e-20 70.6 3.7 7.2e-20 70.6 3.7 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) OAD_gamma PF04277.13 ETO17358.1 - 0.025 15.2 0.7 0.076 13.6 0.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF3782 PF12644.7 ETO17358.1 - 0.13 12.4 0.0 0.64 10.2 0.0 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) cNMP_binding PF00027.29 ETO17359.1 - 2.9e-05 24.0 0.0 4.3e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain HSP70 PF00012.20 ETO17361.1 - 7.7e-155 516.4 0.7 9.6e-155 516.1 0.7 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO17361.1 - 1.4e-05 24.1 0.0 4.3e-05 22.5 0.0 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 ETO17361.1 - 0.003 17.3 0.0 0.0063 16.2 0.0 1.5 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain DUF5624 PF18538.1 ETO17361.1 - 0.62 10.2 2.6 3.4 7.8 1.6 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5624) FlxA PF14282.6 ETO17361.1 - 1 9.4 21.3 0.025 14.5 11.7 2.2 1 1 0 2 2 2 0 FlxA-like protein WD40 PF00400.32 ETO17362.1 - 1.5e-22 79.5 11.7 4.5e-08 33.6 0.2 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17362.1 - 1.8e-07 31.4 0.0 0.011 16.0 0.0 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO17362.1 - 4e-06 25.8 1.8 0.012 14.2 0.1 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO17362.1 - 0.0014 18.0 2.3 0.005 16.2 2.3 1.9 1 1 1 2 2 2 1 WD40-like domain HARP PF07443.13 ETO17362.1 - 0.081 12.6 0.0 0.61 9.8 0.0 2.2 2 0 0 2 2 2 0 HepA-related protein (HARP) FMN_red PF03358.15 ETO17363.1 - 1e-14 54.6 0.0 1.4e-14 54.1 0.0 1.1 1 0 0 1 1 1 1 NADPH-dependent FMN reductase Flavodoxin_2 PF02525.17 ETO17363.1 - 0.0015 18.3 0.0 0.0022 17.7 0.0 1.3 1 1 0 1 1 1 1 Flavodoxin-like fold DUF5380 PF17351.2 ETO17363.1 - 0.013 15.4 0.1 0.02 14.7 0.1 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5380) Adenylsucc_synt PF00709.21 ETO17364.1 - 6.3e-78 262.5 0.0 1.5e-77 261.3 0.0 1.5 1 1 0 1 1 1 1 Adenylosuccinate synthetase tRNA-synt_2 PF00152.20 ETO17365.1 - 8.5e-36 123.6 0.0 9e-36 123.5 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) DUF3863 PF12979.7 ETO17365.1 - 0.15 10.9 0.0 0.43 9.4 0.0 1.7 1 1 1 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3863) Y_phosphatase3 PF13350.6 ETO17366.1 - 0.051 13.5 0.1 0.074 13.0 0.1 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family Ank_2 PF12796.7 ETO17367.1 - 1.2e-05 25.8 1.9 0.0014 19.2 0.2 2.3 1 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO17367.1 - 0.00023 21.7 0.0 0.002 18.7 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO17367.1 - 0.1 13.1 0.4 7.3 7.2 0.0 3.2 3 1 0 3 3 3 0 Ankyrin repeat Ank_5 PF13857.6 ETO17367.1 - 0.15 12.4 0.0 11 6.5 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) ABC2_membrane PF01061.24 ETO17369.1 - 1.3e-41 142.4 14.5 1.6e-41 142.1 14.5 1.1 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO17369.1 - 6.9e-05 22.1 17.3 0.00012 21.3 17.3 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein CRCB PF02537.15 ETO17369.1 - 0.085 13.2 2.7 0.11 12.9 0.2 2.2 1 1 1 2 2 2 0 CrcB-like protein, Camphor Resistance (CrcB) Nucleoside_tran PF01733.18 ETO17370.1 - 4.3e-16 59.2 12.1 4.3e-16 59.2 12.1 1.7 2 0 0 2 2 2 1 Nucleoside transporter DUF948 PF06103.11 ETO17370.1 - 0.17 12.2 0.8 55 4.1 0.0 3.3 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Jnk-SapK_ap_N PF09744.9 ETO17370.1 - 0.18 12.0 5.8 1.1 9.4 0.3 2.5 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Osmo_CC PF08946.10 ETO17370.1 - 0.23 11.7 0.9 0.47 10.7 0.2 1.9 2 0 0 2 2 2 0 Osmosensory transporter coiled coil DUF4064 PF13273.6 ETO17370.1 - 1.8 8.9 7.9 1.9 8.8 3.6 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF4064) Phtf-FEM1B_bdg PF12129.8 ETO17370.1 - 6.2 6.6 11.6 0.98 9.2 5.5 2.3 1 1 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor SAM_2 PF07647.17 ETO17371.1 - 9.9e-13 48.0 0.0 1.8e-12 47.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO17371.1 - 7.9e-11 42.2 0.0 1.5e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO17371.1 - 0.009 16.0 0.2 0.02 14.8 0.0 1.7 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain Hydrolase_4 PF12146.8 ETO17372.1 - 1.6e-08 34.1 0.2 8.9e-07 28.4 0.0 2.7 3 0 0 3 3 3 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO17372.1 - 6e-06 27.0 0.0 0.0023 18.6 0.0 2.1 2 0 0 2 2 2 2 Alpha/beta hydrolase family DUF1100 PF06500.11 ETO17372.1 - 8.5e-05 21.5 0.0 0.00013 20.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF1100) Abhydrolase_1 PF00561.20 ETO17372.1 - 0.00072 19.3 0.0 0.099 12.3 0.0 2.4 2 1 0 2 2 2 2 alpha/beta hydrolase fold PAF-AH_p_II PF03403.13 ETO17372.1 - 0.0015 17.2 0.0 0.0025 16.4 0.0 1.4 1 0 0 1 1 1 1 Platelet-activating factor acetylhydrolase, isoform II Peptidase_S9 PF00326.21 ETO17372.1 - 0.0019 17.7 0.0 0.22 11.0 0.0 3.2 3 0 0 3 3 3 1 Prolyl oligopeptidase family AXE1 PF05448.12 ETO17372.1 - 0.018 13.7 0.0 14 4.3 0.0 3.2 2 1 1 3 3 3 0 Acetyl xylan esterase (AXE1) Haemadin PF09065.10 ETO17372.1 - 0.12 12.2 0.1 0.26 11.1 0.1 1.6 1 0 0 1 1 1 0 Haemadin TPR_10 PF13374.6 ETO17374.1 - 1.1e-11 44.2 0.9 0.0087 15.9 0.0 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17374.1 - 4.4e-11 42.9 1.9 5.8e-07 29.7 0.0 3.1 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17374.1 - 6.4e-11 41.5 4.3 0.0027 17.6 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17374.1 - 1.1e-08 34.6 8.8 0.06 13.5 0.1 4.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17374.1 - 7.4e-08 32.0 11.6 0.025 14.8 0.1 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17374.1 - 0.0001 22.0 13.7 0.066 13.1 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17374.1 - 0.0066 16.1 4.5 4.6 7.0 0.1 3.9 3 0 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 ETO17374.1 - 0.12 13.1 1.9 2.2 9.1 0.1 3.4 3 1 0 3 3 3 0 Tetratricopeptide repeat MIT PF04212.18 ETO17374.1 - 2.3 8.4 10.7 29 4.8 1.4 4.8 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain Pkinase PF00069.25 ETO17375.1 - 1.1e-50 172.5 0.1 2.4e-50 171.4 0.1 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17375.1 - 3.6e-20 72.3 0.1 7.3e-20 71.3 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO17375.1 - 2.8e-05 23.6 0.0 4.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO17375.1 - 0.00026 21.0 0.1 0.011 15.6 0.0 2.2 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ETO17375.1 - 0.0097 14.9 0.0 0.12 11.3 0.0 2.2 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 ETO17375.1 - 0.033 13.5 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 Kinase-like WD40 PF00400.32 ETO17376.1 - 2.9e-14 53.2 16.0 0.00096 19.9 1.8 4.5 4 0 0 4 4 4 4 WD domain, G-beta repeat eIF2A PF08662.11 ETO17376.1 - 5.1e-06 26.5 0.5 1.7e-05 24.8 0.2 1.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ETO17376.1 - 6.8e-05 23.1 2.0 0.39 11.0 0.5 3.4 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2829 PF11195.8 ETO17376.1 - 0.13 12.5 1.3 2.7 8.3 0.0 2.8 2 2 0 2 2 2 0 Protein of unknown function (DUF2829) RNA_pol_Rpc82 PF05645.13 ETO17377.1 - 0.012 15.4 3.1 0.013 15.2 3.1 1.2 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 DUF4778 PF16008.5 ETO17377.1 - 0.03 14.4 3.8 0.034 14.2 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) KIND PF16474.5 ETO17377.1 - 0.077 12.9 3.3 0.11 12.4 3.3 1.2 1 0 0 1 1 1 0 Kinase non-catalytic C-lobe domain DUF2118 PF09891.9 ETO17377.1 - 0.31 11.0 2.5 0.5 10.3 2.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2118) AATF-Che1 PF13339.6 ETO17377.1 - 0.32 11.7 9.1 0.51 11.0 9.1 1.3 1 0 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF4820 PF16091.5 ETO17377.1 - 1.1 8.5 6.0 1.5 8.1 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CHIP_TPR_N PF18391.1 ETO17377.1 - 5.6 7.8 15.0 2.1 9.1 11.5 1.9 1 1 1 2 2 2 0 CHIP N-terminal tetratricopeptide repeat domain VASP_tetra PF08776.11 ETO17378.1 - 0.0057 16.2 16.1 0.07 12.7 2.2 3.9 3 0 0 3 3 3 3 VASP tetramerisation domain DUF3439 PF11921.8 ETO17378.1 - 0.48 10.4 3.2 0.99 9.4 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF676 PF05057.14 ETO17378.1 - 1.4 8.3 5.8 0.67 9.4 3.0 1.8 2 0 0 2 2 2 0 Putative serine esterase (DUF676) AP3D1 PF06375.11 ETO17379.1 - 4.7 7.4 21.3 5.4 7.2 21.3 1.0 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF1168 PF06658.12 ETO17379.1 - 7 6.5 23.4 10 6.0 23.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Kinesin PF00225.23 ETO17381.1 - 5.6e-05 22.2 0.4 0.00012 21.1 0.0 1.7 2 0 0 2 2 2 1 Kinesin motor domain DUF2046 PF09755.9 ETO17381.1 - 0.02 14.2 1.0 0.02 14.2 1.0 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein H4 (DUF2046) DUF4140 PF13600.6 ETO17381.1 - 0.18 12.3 1.7 0.19 12.2 0.2 1.8 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Spc24 PF08286.11 ETO17381.1 - 0.23 11.7 5.0 0.078 13.2 1.3 2.1 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 RGS PF00615.19 ETO17382.1 - 4.1e-12 46.4 1.6 7.9e-12 45.5 1.6 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain TPR_2 PF07719.17 ETO17383.1 - 7.3e-18 63.2 10.3 0.00077 19.4 0.3 7.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17383.1 - 1.1e-17 63.0 9.8 2.4e-05 24.0 0.5 7.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17383.1 - 1.1e-14 54.8 0.0 0.0021 18.7 0.0 4.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17383.1 - 1.3e-13 50.3 7.5 0.0053 17.0 0.1 6.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17383.1 - 2e-13 49.9 0.1 0.076 13.9 0.0 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17383.1 - 7.1e-13 48.0 0.2 0.00021 20.9 0.0 4.9 3 1 2 5 5 5 2 TPR repeat TPR_19 PF14559.6 ETO17383.1 - 1.6e-12 47.7 0.4 0.0079 16.7 0.0 4.3 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17383.1 - 3.1e-11 42.5 0.1 0.13 12.4 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17383.1 - 5.7e-10 38.6 7.2 0.017 15.3 0.4 7.8 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17383.1 - 3.4e-06 27.2 3.5 4.9 7.5 0.0 5.4 3 2 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17383.1 - 1.4e-05 25.4 0.5 0.059 14.0 0.0 4.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO17383.1 - 0.0036 17.4 0.0 1.9 8.7 0.0 3.8 3 1 2 5 5 5 2 Tetratricopeptide repeat DUF410 PF04190.13 ETO17383.1 - 0.0066 16.3 0.2 0.9 9.3 0.0 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF410) TPR_10 PF13374.6 ETO17383.1 - 0.0066 16.3 8.0 9.9 6.2 0.0 5.1 6 0 0 6 6 6 1 Tetratricopeptide repeat Ribosomal_L22e PF01776.17 ETO17384.1 - 4.6e-15 55.9 0.4 1.1e-14 54.8 0.4 1.6 1 0 0 1 1 1 1 Ribosomal L22e protein family CDC27 PF09507.10 ETO17384.1 - 0.57 9.5 29.2 0.67 9.3 29.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 WD40 PF00400.32 ETO17385.1 - 1.6e-16 60.4 12.1 1.3e-07 32.2 0.4 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17385.1 - 1.1e-07 32.0 0.1 0.0012 19.1 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO17385.1 - 1.2e-05 24.2 3.2 0.0016 17.2 2.3 2.6 1 1 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO17385.1 - 0.005 16.7 3.9 0.28 11.0 1.5 2.6 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Adhesin_E PF16747.5 ETO17385.1 - 0.061 13.4 2.1 0.098 12.7 0.3 2.0 1 1 1 2 2 2 0 Surface-adhesin protein E Thermopsin PF05317.11 ETO17385.1 - 0.36 10.3 6.2 0.38 10.2 2.3 2.0 1 1 1 2 2 2 0 Thermopsin Ank_5 PF13857.6 ETO17386.1 - 5.7e-05 23.3 0.0 0.00018 21.7 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO17386.1 - 0.0058 17.2 0.0 0.015 15.9 0.0 1.7 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO17386.1 - 0.016 15.8 0.0 0.035 14.7 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) RRM_Rrp7 PF17799.1 ETO17386.1 - 0.047 13.5 1.4 0.1 12.4 1.4 1.8 1 1 0 1 1 1 0 Rrp7 RRM-like N-terminal domain Ank_3 PF13606.6 ETO17386.1 - 0.086 13.4 0.0 0.92 10.3 0.0 2.4 2 0 0 2 2 2 0 Ankyrin repeat TMEM154 PF15102.6 ETO17388.1 - 0.76 9.7 0.0 0.76 9.7 0.0 2.8 3 0 0 3 3 3 0 TMEM154 protein family Menin PF05053.13 ETO17389.1 - 3.6 5.8 11.4 0.063 11.6 4.2 1.6 2 0 0 2 2 2 0 Menin Secretin_N_2 PF07655.13 ETO17389.1 - 5.6 7.6 18.9 18 5.9 18.9 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain Spore_coat_CotO PF14153.6 ETO17390.1 - 0.066 13.1 12.3 0.098 12.6 12.3 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Cellulose_synt PF03552.14 ETO17390.1 - 0.14 10.7 6.3 0.18 10.3 6.3 1.1 1 0 0 1 1 1 0 Cellulose synthase Neur_chan_memb PF02932.16 ETO17390.1 - 0.36 10.9 2.6 0.4 10.7 2.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO17390.1 - 0.5 9.1 9.2 0.6 8.8 9.2 1.1 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 ETO17390.1 - 2.1 7.3 5.0 3 6.8 5.0 1.3 1 0 0 1 1 1 0 Tumour-associated protein Sec62 PF03839.16 ETO17390.1 - 2.7 7.4 9.3 4.5 6.7 9.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Zip PF02535.22 ETO17390.1 - 5.2 6.2 7.5 6.7 5.8 7.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter fn3_5 PF06280.12 ETO17391.1 - 0.00013 22.6 1.8 0.033 14.9 0.5 2.8 2 0 0 2 2 2 2 Fn3-like domain Zn_ribbon_SprT PF17283.2 ETO17391.1 - 0.0047 16.8 0.4 1 9.4 0.2 2.7 2 0 0 2 2 2 1 SprT-like zinc ribbon domain NUDIX PF00293.28 ETO17391.1 - 0.0055 16.8 0.7 0.0098 15.9 0.0 1.8 2 0 0 2 2 2 1 NUDIX domain zf-Di19 PF05605.12 ETO17391.1 - 0.013 15.8 4.2 0.38 11.1 0.6 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding SDA1 PF05285.12 ETO17391.1 - 0.029 13.8 20.9 0.26 10.7 9.9 2.2 2 0 0 2 2 2 0 SDA1 Mur_ligase PF01225.25 ETO17391.1 - 0.052 13.9 0.1 0.17 12.3 0.1 1.9 1 0 0 1 1 1 0 Mur ligase family, catalytic domain C1_4 PF07975.12 ETO17391.1 - 0.11 12.7 2.3 2.8 8.2 0.0 3.5 3 0 0 3 3 3 0 TFIIH C1-like domain Sigma70_ner PF04546.13 ETO17391.1 - 0.2 11.5 12.4 0.15 11.9 5.4 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region zf-C2H2_4 PF13894.6 ETO17391.1 - 1.4 9.9 9.5 5.2 8.2 0.1 3.6 3 0 0 3 3 3 0 C2H2-type zinc finger X8 PF07983.13 ETO17392.1 - 0.0011 19.6 0.1 0.0024 18.5 0.1 1.6 1 0 0 1 1 1 1 X8 domain SEFIR PF08357.11 ETO17392.1 - 0.0044 17.3 0.3 0.0062 16.8 0.3 1.2 1 0 0 1 1 1 1 SEFIR domain ACBP PF00887.19 ETO17392.1 - 0.031 14.5 0.3 0.096 12.9 0.0 1.9 2 0 0 2 2 2 0 Acyl CoA binding protein RHINO PF15319.6 ETO17392.1 - 0.077 13.0 1.6 0.11 12.5 1.6 1.3 1 0 0 1 1 1 0 RAD9, RAD1, HUS1-interacting nuclear orphan protein DUF3381 PF11861.8 ETO17392.1 - 0.098 12.5 5.8 0.14 12.0 3.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Pho86 PF11124.8 ETO17394.1 - 2.4 7.6 11.9 3.1 7.2 11.9 1.2 1 0 0 1 1 1 0 Inorganic phosphate transporter Pho86 WD40 PF00400.32 ETO17395.1 - 4.4e-10 40.0 0.2 0.079 13.9 0.0 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17395.1 - 8e-07 29.3 0.0 0.025 14.8 0.0 3.4 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CSTF1_dimer PF16699.5 ETO17395.1 - 9.3e-07 28.5 0.1 2e-06 27.5 0.1 1.5 1 0 0 1 1 1 1 Cleavage stimulation factor subunit 1, dimerisation domain Ge1_WD40 PF16529.5 ETO17395.1 - 0.00018 20.6 0.6 0.00053 19.0 0.2 1.8 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO17395.1 - 0.016 15.1 0.0 0.055 13.4 0.0 1.9 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A GATase PF00117.28 ETO17395.1 - 0.06 13.1 0.2 0.06 13.1 0.2 1.8 2 0 0 2 2 2 0 Glutamine amidotransferase class-I D123 PF07065.14 ETO17398.1 - 1.1e-17 64.2 6.7 4.8e-16 58.8 6.7 2.6 1 1 0 1 1 1 1 D123 R2K_2 PF18299.1 ETO17398.1 - 6.8e-05 22.8 0.5 0.0012 18.8 0.5 2.4 1 1 0 1 1 1 1 ATP-grasp domain, R2K clade family 2 R2K_3 PF14243.6 ETO17398.1 - 0.18 11.8 0.0 0.34 10.9 0.0 1.7 1 1 0 1 1 1 0 ATP-grasp domain, R2K clade family 3 Ion_trans PF00520.31 ETO17399.1 - 0.0022 17.2 0.1 0.15 11.3 0.0 2.0 2 0 0 2 2 2 1 Ion transport protein Glucos_trans_II PF14264.6 ETO17399.1 - 0.012 15.0 2.0 0.69 9.2 0.3 2.1 2 0 0 2 2 2 0 Glucosyl transferase GtrII zf-LITAF-like PF10601.9 ETO17399.1 - 0.028 14.7 3.7 0.25 11.6 2.1 2.3 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain DUF997 PF06196.12 ETO17399.1 - 0.029 14.4 0.9 0.64 10.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF997) SARAF PF06682.12 ETO17399.1 - 0.035 13.8 10.4 0.0086 15.8 6.2 1.9 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis AA_permease_2 PF13520.6 ETO17399.1 - 0.066 12.0 3.7 2.5 6.8 0.5 2.1 2 0 0 2 2 2 0 Amino acid permease DUF3810 PF12725.7 ETO17399.1 - 0.079 12.3 2.2 1 8.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) DUF2207 PF09972.9 ETO17399.1 - 0.12 11.1 2.8 0.96 8.1 2.8 2.2 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) GWT1 PF06423.12 ETO17399.1 - 0.2 11.7 3.1 3.9 7.6 0.3 2.7 2 1 1 3 3 3 0 GWT1 TSLP PF15216.6 ETO17399.1 - 0.4 11.0 7.5 0.36 11.1 0.6 2.6 2 0 0 2 2 2 0 Thymic stromal lymphopoietin O-ag_pol_Wzy PF14296.6 ETO17399.1 - 0.46 9.1 9.0 2.2 6.8 1.2 2.1 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy O-antigen_lig PF13425.6 ETO17399.1 - 0.63 8.8 10.3 0.75 8.5 1.5 2.1 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Sigma_reg_N PF13800.6 ETO17399.1 - 0.65 10.3 6.0 5.5 7.4 0.6 2.5 2 0 0 2 2 2 0 Sigma factor regulator N-terminal DUF2663 PF10864.8 ETO17399.1 - 3.9 7.9 10.5 3.6 8.0 1.7 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2663) Kelch_6 PF13964.6 ETO17400.1 - 2.8e-05 24.2 2.8 0.57 10.6 0.3 4.1 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO17400.1 - 0.0035 17.3 0.0 0.014 15.3 0.0 2.1 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO17400.1 - 0.21 11.6 3.2 13 6.0 0.2 3.8 4 0 0 4 4 4 0 Kelch motif DUF1708 PF08101.11 ETO17401.1 - 0.014 14.6 14.3 0.017 14.3 14.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) Miff PF05644.11 ETO17401.1 - 0.026 14.2 1.1 0.026 14.2 1.1 2.5 1 1 1 2 2 2 0 Mitochondrial and peroxisomal fission factor Mff LMBR1 PF04791.16 ETO17401.1 - 7.1 5.4 7.6 7.9 5.3 7.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 ETO17401.1 - 9.7 5.4 10.3 12 5.2 10.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Y_phosphatase2 PF03162.13 ETO17402.1 - 4.9e-52 175.8 1.2 7.2e-52 175.3 0.1 2.0 2 0 0 2 2 2 1 Tyrosine phosphatase family AKAP7_NLS PF10469.9 ETO17402.1 - 3.2e-13 50.1 6.0 6.1e-12 45.9 6.0 2.6 1 1 0 1 1 1 1 AKAP7 2'5' RNA ligase-like domain 2_5_RNA_ligase2 PF13563.6 ETO17402.1 - 0.0074 16.2 4.4 0.016 15.1 4.4 1.6 1 1 0 1 1 1 1 2'-5' RNA ligase superfamily Sigma70_ner PF04546.13 ETO17402.1 - 0.0092 15.9 17.0 0.2 11.5 3.8 2.8 2 0 0 2 2 2 2 Sigma-70, non-essential region Y_phosphatase3 PF13350.6 ETO17402.1 - 0.026 14.5 0.2 0.099 12.6 0.0 2.1 2 0 0 2 2 2 0 Tyrosine phosphatase family LigT_PEase PF02834.16 ETO17402.1 - 0.083 13.1 1.0 32 4.8 0.0 3.5 3 1 0 3 3 3 0 LigT like Phosphoesterase Mem_trans PF03547.18 ETO17402.1 - 3.8 5.8 6.9 0.11 10.8 0.1 2.0 2 0 0 2 2 2 0 Membrane transport protein Myc_N PF01056.18 ETO17402.1 - 5.3 6.9 15.4 0.048 13.6 4.9 2.4 2 0 0 2 2 2 0 Myc amino-terminal region Usp PF00582.26 ETO17402.1 - 8.4 6.9 5.8 3 8.4 1.1 2.6 3 0 0 3 3 3 0 Universal stress protein family Peptidase_S10 PF00450.22 ETO17404.1 - 1.8e-48 166.0 6.7 2e-48 165.9 6.7 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Ank_2 PF12796.7 ETO17405.1 - 1.1e-10 42.0 0.3 2.2e-10 41.0 0.3 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO17405.1 - 2e-10 40.7 1.7 3.4e-07 30.4 0.1 2.9 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO17405.1 - 2.2e-09 37.7 2.1 3.2e-08 33.9 0.4 2.9 1 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO17405.1 - 2.1e-08 33.8 4.9 0.00093 19.5 0.0 4.7 5 0 0 5 5 5 2 Ankyrin repeat Ank PF00023.30 ETO17405.1 - 0.0026 18.1 0.2 0.59 10.7 0.1 2.6 2 0 0 2 2 2 1 Ankyrin repeat Peptidase_S10 PF00450.22 ETO17406.1 - 1.1e-31 110.7 0.1 1.3e-31 110.5 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase Peptidase_S10 PF00450.22 ETO17407.1 - 1.3e-07 31.5 0.0 1.6e-07 31.1 0.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase PI3K_1B_p101 PF10486.9 ETO17409.1 - 0.01 13.6 0.9 0.012 13.4 0.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NPR3 PF03666.13 ETO17409.1 - 0.24 10.1 6.2 0.37 9.5 6.2 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PH_4 PF15404.6 ETO17409.1 - 1.4 8.7 5.0 3.3 7.5 5.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain Macoilin PF09726.9 ETO17409.1 - 1.4 7.4 15.1 1.8 7.0 15.1 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO17409.1 - 2.1 7.0 7.5 3.1 6.4 7.5 1.2 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO17409.1 - 8.5 5.6 7.2 16 4.7 7.2 1.4 1 0 0 1 1 1 0 NOA36 protein LTD PF00932.19 ETO17410.1 - 3.7e-07 30.5 0.3 8e-07 29.4 0.0 1.8 1 1 1 2 2 2 1 Lamin Tail Domain Membralin PF09746.9 ETO17410.1 - 1.9 7.5 4.4 2.3 7.2 4.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO17410.1 - 4.1 6.1 5.6 5.2 5.7 5.6 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO17410.1 - 7.9 5.2 8.8 11 4.7 8.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Helicase_C PF00271.31 ETO17412.1 - 1.5e-25 89.7 0.5 2.4e-25 89.0 0.2 1.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain fragilysinNterm PF16376.5 ETO17412.1 - 0.033 13.9 0.0 0.061 13.1 0.0 1.4 1 0 0 1 1 1 0 N-terminal domain of fragilysin tRNA-synt_1b PF00579.25 ETO17412.1 - 0.078 12.3 0.0 0.089 12.1 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (W and Y) Ribosomal_L19e PF01280.20 ETO17414.1 - 0.017 15.2 0.3 0.023 14.8 0.3 1.2 1 0 0 1 1 1 0 Ribosomal protein L19e Orf78 PF06024.12 ETO17415.1 - 0.01 16.2 2.5 0.01 16.2 2.5 1.9 2 0 0 2 2 2 1 Orf78 (ac78) PSI_integrin PF17205.3 ETO17415.1 - 4.3 7.2 6.7 0.71 9.7 2.7 1.8 2 0 0 2 2 2 0 Integrin plexin domain Secretin_N_2 PF07655.13 ETO17415.1 - 7.4 7.2 24.7 3.4 8.3 11.8 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3278 PF11683.8 ETO17416.1 - 0.056 13.5 0.0 0.1 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3278) WD40 PF00400.32 ETO17417.1 - 5.8e-20 71.2 15.8 0.00023 21.9 0.8 6.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17417.1 - 3.2e-07 30.5 0.4 3.2 8.1 0.0 5.4 4 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO17417.1 - 2.1e-05 25.1 3.1 2.1e-05 25.1 3.1 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger PolyA_pol PF01743.20 ETO17417.1 - 0.16 12.4 0.4 0.39 11.2 0.4 1.6 1 0 0 1 1 1 0 Poly A polymerase head domain DUF3987 PF13148.6 ETO17417.1 - 0.24 10.4 1.5 0.36 9.8 1.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DIMCO_N PF16844.5 ETO17417.1 - 0.36 11.2 2.3 0.83 10.0 1.8 1.9 1 1 0 1 1 1 0 Dinitrogenase iron-molybdenum cofactor, N-terminal DivIC PF04977.15 ETO17417.1 - 7 6.5 10.8 18 5.2 0.3 2.9 3 0 0 3 3 3 0 Septum formation initiator PUA_2 PF14306.6 ETO17418.1 - 0.0047 16.6 0.6 0.012 15.3 0.0 1.9 1 1 0 1 1 1 1 PUA-like domain GCN5L1 PF06320.13 ETO17418.1 - 0.16 12.1 11.7 0.043 13.9 3.5 2.4 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) AP3D1 PF06375.11 ETO17418.1 - 0.28 11.4 12.1 0.4 10.9 12.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Mu-like_Pro PF10123.9 ETO17418.1 - 1.5 8.3 8.5 1.9 7.9 8.5 1.1 1 0 0 1 1 1 0 Mu-like prophage I protein YtxH PF12732.7 ETO17418.1 - 2.5 8.7 7.5 1.4 9.5 5.2 1.7 1 1 1 2 2 2 0 YtxH-like protein Zeta_toxin PF06414.12 ETO17419.1 - 2.9e-07 30.0 0.0 5.2e-07 29.2 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 ETO17419.1 - 0.021 15.0 0.0 0.049 13.8 0.0 1.6 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO17419.1 - 0.14 12.5 0.0 0.3 11.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ETO17420.1 - 0.00039 19.8 0.1 0.00047 19.5 0.1 1.1 1 0 0 1 1 1 1 Zeta toxin DUF3244 PF11589.8 ETO17420.1 - 0.069 13.2 0.3 0.11 12.6 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3244) Aa_trans PF01490.18 ETO17421.1 - 3.1e-31 108.5 5.8 3.8e-31 108.2 5.1 1.6 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Clathrin PF00637.20 ETO17422.1 - 9.5e-12 45.0 1.7 3.3e-07 30.3 0.5 2.4 2 0 0 2 2 2 2 Region in Clathrin and VPS HU-CCDC81_bac_2 PF18175.1 ETO17422.1 - 0.039 13.8 0.0 2.8 7.9 0.0 2.4 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Pkinase PF00069.25 ETO17424.1 - 4.7e-21 75.3 0.0 5.6e-21 75.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17424.1 - 2.8e-06 26.8 0.9 4e-05 23.0 0.9 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Sec7 PF01369.20 ETO17425.1 - 8.8e-06 25.5 1.2 1.5e-05 24.7 1.2 1.5 1 1 0 1 1 1 1 Sec7 domain ELFV_dehydrog PF00208.21 ETO17425.1 - 0.081 12.6 0.5 0.26 11.0 0.3 1.9 2 0 0 2 2 2 0 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase Ribosomal_L26 PF16906.5 ETO17426.1 - 0.02 15.4 0.0 0.042 14.3 0.0 1.7 1 1 0 1 1 1 0 Ribosomal proteins L26 eukaryotic, L24P archaeal Sec62 PF03839.16 ETO17427.1 - 0.012 15.1 0.0 0.02 14.4 0.0 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 SPC25 PF06703.11 ETO17427.1 - 0.065 13.0 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) Importin_rep_4 PF18808.1 ETO17427.1 - 0.083 13.2 0.3 0.17 12.2 0.3 1.5 1 0 0 1 1 1 0 Importin repeat FYVE PF01363.21 ETO17428.1 - 1e-12 48.0 15.5 2.6e-12 46.7 15.5 1.7 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ETO17428.1 - 0.041 14.1 9.9 0.11 12.7 9.9 1.8 1 1 0 1 1 1 0 FYVE-type zinc finger MAP70 PF07058.11 ETO17428.1 - 0.041 12.6 3.1 0.044 12.5 3.1 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 Menin PF05053.13 ETO17428.1 - 0.33 9.3 7.5 0.44 8.9 7.5 1.1 1 0 0 1 1 1 0 Menin LMBR1 PF04791.16 ETO17428.1 - 1.6 7.6 4.7 1.8 7.4 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein zf-C3HC4 PF00097.25 ETO17429.1 - 3.9e-06 26.6 2.9 9.7e-06 25.4 2.9 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO17429.1 - 1.8e-05 25.0 4.8 3.2e-05 24.2 4.8 1.5 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETO17429.1 - 0.0014 18.8 6.6 0.003 17.8 6.6 1.6 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETO17429.1 - 0.0033 17.2 6.6 0.01 15.7 6.6 1.8 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO17429.1 - 0.0047 16.6 1.0 0.0047 16.6 1.0 1.9 2 0 0 2 2 2 1 RING-like zinc finger Zn-ribbon_8 PF09723.10 ETO17429.1 - 0.018 15.2 2.1 0.2 11.8 0.5 2.5 2 0 0 2 2 2 0 Zinc ribbon domain zf-RING_5 PF14634.6 ETO17429.1 - 0.025 14.5 3.4 0.05 13.6 3.4 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_4 PF14570.6 ETO17429.1 - 0.049 13.4 6.3 0.1 12.4 6.3 1.6 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain MAGP PF05507.11 ETO17429.1 - 0.062 13.7 0.8 0.066 13.6 0.8 1.1 1 0 0 1 1 1 0 Microfibril-associated glycoprotein (MAGP) SLAIN PF15301.6 ETO17429.1 - 0.19 10.9 0.2 0.21 10.8 0.2 1.1 1 0 0 1 1 1 0 SLAIN motif-containing family DZR PF12773.7 ETO17429.1 - 0.24 11.4 4.2 0.83 9.7 4.2 1.9 1 1 0 1 1 1 0 Double zinc ribbon PBP1_TM PF14812.6 ETO17429.1 - 0.34 11.3 6.3 0.52 10.7 6.3 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-RING_UBOX PF13445.6 ETO17429.1 - 0.41 10.7 5.4 1.6 8.8 0.7 2.4 2 0 0 2 2 2 0 RING-type zinc-finger zf-C3H2C3 PF17122.5 ETO17429.1 - 1.3 9.1 6.8 6.7 6.8 6.8 2.1 1 1 0 1 1 1 0 Zinc-finger UPF0261 PF06792.11 ETO17430.1 - 0.11 11.4 0.2 0.13 11.2 0.2 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0261) Pim PF16765.5 ETO17432.1 - 0.0073 16.4 1.2 0.018 15.2 0.2 1.9 2 0 0 2 2 2 1 Pesticin immunity protein EPOP PF15223.6 ETO17432.1 - 0.24 10.7 13.8 0.29 10.4 13.8 1.2 1 0 0 1 1 1 0 Elongin BC and Polycomb repressive complex 2-associated protein FAM181 PF15238.6 ETO17432.1 - 1.2 8.9 7.5 1.4 8.7 7.5 1.0 1 0 0 1 1 1 0 FAM181 DUF4407 PF14362.6 ETO17432.1 - 1.3 8.3 11.2 1.6 8.0 11.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cnd1 PF12717.7 ETO17433.1 - 0.0002 21.5 3.1 0.0003 20.9 0.3 2.2 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO17433.1 - 0.0012 18.9 0.6 1.6 9.2 0.0 3.5 3 0 0 3 3 3 2 HEAT repeat TIP120 PF08623.10 ETO17433.1 - 0.011 15.6 0.2 0.011 15.6 0.2 2.7 2 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) HEAT_EZ PF13513.6 ETO17433.1 - 0.029 14.9 0.4 7 7.3 0.1 2.8 2 0 0 2 2 2 0 HEAT-like repeat PqqD PF05402.12 ETO17433.1 - 0.06 13.6 0.1 0.32 11.3 0.0 2.2 2 0 0 2 2 2 0 Coenzyme PQQ synthesis protein D (PqqD) CsrA PF02599.16 ETO17434.1 - 0.23 11.4 6.7 2.5 8.1 0.1 4.0 3 0 0 3 3 3 0 Global regulator protein family OMP_b-brl_2 PF13568.6 ETO17434.1 - 0.31 11.0 6.7 37 4.3 0.1 5.5 2 2 1 3 3 3 0 Outer membrane protein beta-barrel domain DA1-like PF12315.8 ETO17435.1 - 0.015 14.7 0.1 0.027 13.9 0.1 1.4 1 0 0 1 1 1 0 Protein DA1 DUF488 PF04343.13 ETO17435.1 - 0.055 14.1 0.9 0.055 14.1 0.9 2.1 2 0 0 2 2 2 0 Protein of unknown function, DUF488 Filament PF00038.21 ETO17435.1 - 0.21 11.2 14.5 0.6 9.6 3.6 2.1 2 0 0 2 2 2 0 Intermediate filament protein Fib_alpha PF08702.10 ETO17435.1 - 0.48 10.6 12.7 0.4 10.9 3.1 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family ADIP PF11559.8 ETO17435.1 - 0.5 10.5 14.5 1.1 9.3 3.3 2.2 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding AAA_11 PF13086.6 ETO17435.1 - 0.52 10.0 9.2 1.9 8.2 9.2 1.7 1 1 0 1 1 1 0 AAA domain Tfb4 PF03850.14 ETO17435.1 - 0.96 8.9 3.7 0.26 10.7 0.1 1.7 2 0 0 2 2 2 0 Transcription factor Tfb4 RIC3 PF15361.6 ETO17435.1 - 3.9 7.9 9.8 6.8 7.1 0.6 2.1 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 DUF1151 PF06625.11 ETO17435.1 - 4.4 7.3 14.0 0.49 10.3 3.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1151) Tropomyosin_1 PF12718.7 ETO17435.1 - 4.4 7.4 17.9 1.9 8.6 3.3 2.1 2 0 0 2 2 2 0 Tropomyosin like UPF0449 PF15136.6 ETO17435.1 - 8.5 6.9 12.6 8.2 7.0 2.9 2.1 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Pkinase PF00069.25 ETO17436.1 - 5.2e-80 268.6 0.0 8.2e-80 268.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17436.1 - 4.3e-40 137.6 0.0 6.7e-40 137.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO17436.1 - 1.5e-05 24.0 1.3 2.7e-05 23.1 0.1 2.0 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ETO17436.1 - 3.5e-05 23.8 0.1 0.0006 19.8 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO17436.1 - 0.00036 19.9 0.0 0.0028 17.0 0.0 2.2 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 ETO17436.1 - 0.0014 18.3 0.1 0.0027 17.3 0.1 1.4 1 0 0 1 1 1 1 RIO1 family Kdo PF06293.14 ETO17436.1 - 0.0015 17.9 0.1 0.0046 16.4 0.0 1.6 1 1 1 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family H-K_ATPase_N PF09040.11 ETO17436.1 - 0.16 12.5 7.5 0.4 11.1 4.4 3.1 4 0 0 4 4 4 0 Gastric H+/K+-ATPase, N terminal domain AAA_15 PF13175.6 ETO17438.1 - 8.7e-25 88.2 18.9 4.1e-24 86.0 18.9 2.4 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ETO17438.1 - 1.4e-22 80.9 5.0 7.1e-16 58.9 0.9 2.5 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO17438.1 - 1.8e-13 50.5 0.9 3.6e-12 46.2 0.9 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO17438.1 - 8.9e-08 32.9 17.3 1e-06 29.4 17.3 2.1 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO17438.1 - 1.2e-07 32.3 1.8 0.00047 20.7 1.8 2.5 1 1 0 1 1 1 1 ABC transporter VWA_2 PF13519.6 ETO17438.1 - 0.0008 20.0 1.6 0.013 16.2 0.1 2.6 2 0 0 2 2 2 1 von Willebrand factor type A domain AAA_29 PF13555.6 ETO17438.1 - 0.00087 19.0 0.0 0.0017 18.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_13 PF13166.6 ETO17438.1 - 0.00088 18.0 10.5 0.0011 17.7 0.5 2.4 2 1 0 2 2 2 1 AAA domain AAA_24 PF13479.6 ETO17438.1 - 0.0026 17.5 0.0 0.0056 16.4 0.0 1.6 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO17438.1 - 0.0081 16.1 0.7 0.15 12.0 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 ETO17438.1 - 0.013 15.4 0.0 0.052 13.5 0.0 1.9 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 ETO17438.1 - 0.014 15.1 0.0 0.055 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain ATPase_2 PF01637.18 ETO17438.1 - 0.034 14.1 0.3 0.034 14.1 0.3 2.1 1 1 0 2 2 2 0 ATPase domain predominantly from Archaea PhoH PF02562.16 ETO17438.1 - 0.051 13.0 0.1 0.37 10.2 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein ATP_bind_1 PF03029.17 ETO17438.1 - 0.052 13.3 0.2 0.69 9.6 0.0 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_27 PF13514.6 ETO17438.1 - 0.07 12.7 0.7 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETO17438.1 - 0.076 13.4 0.0 0.18 12.2 0.0 1.6 1 0 0 1 1 1 0 AAA domain RELT PF12606.8 ETO17439.1 - 2 7.5 11.0 0.49 9.4 6.7 2.3 2 0 0 2 2 2 0 Tumour necrosis factor receptor superfamily member 19 Glyco_hydro_47 PF01532.20 ETO17440.1 - 1.1e-05 24.6 0.1 1.1e-05 24.6 0.1 1.8 1 1 1 2 2 2 1 Glycosyl hydrolase family 47 Dicty_REP PF05086.12 ETO17440.1 - 0.022 12.8 6.1 0.026 12.5 6.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tir_receptor_C PF07489.11 ETO17440.1 - 0.15 12.0 5.8 0.18 11.8 5.8 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Mucin PF01456.17 ETO17440.1 - 0.28 11.2 15.2 0.36 10.8 15.2 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein SSP160 PF06933.11 ETO17440.1 - 0.48 8.6 12.5 0.6 8.2 12.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 ETO17440.1 - 3.9 5.5 6.5 4.6 5.3 6.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF1980 PF09323.10 ETO17440.1 - 5.2 7.0 10.0 4.4 7.2 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) TMEM154 PF15102.6 ETO17440.1 - 5.3 6.9 7.5 7.6 6.4 7.5 1.2 1 0 0 1 1 1 0 TMEM154 protein family Glyco_hydro_47 PF01532.20 ETO17441.1 - 1.3e-30 106.7 0.8 1.3e-30 106.7 0.8 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 47 LptF_LptG PF03739.14 ETO17442.1 - 0.0018 17.2 1.3 0.0018 17.2 1.3 1.9 2 1 0 2 2 2 1 Lipopolysaccharide export system permease LptF/LptG LAP1C PF05609.12 ETO17442.1 - 0.003 16.7 11.3 0.003 16.7 11.3 2.0 2 0 0 2 2 2 1 Lamina-associated polypeptide 1C (LAP1C) SprA-related PF12118.8 ETO17442.1 - 0.004 16.3 14.1 0.0078 15.4 14.1 1.4 1 0 0 1 1 1 1 SprA-related family NOA36 PF06524.12 ETO17442.1 - 0.0093 15.3 4.2 0.0093 15.3 4.2 2.8 3 0 0 3 3 3 1 NOA36 protein DUF4337 PF14235.6 ETO17442.1 - 0.082 13.0 0.2 0.23 11.6 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MCU PF04678.13 ETO17442.1 - 1.6 8.8 4.9 4.7 7.3 4.4 2.0 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF2721 PF11026.8 ETO17442.1 - 1.7 8.5 13.9 0.098 12.5 5.7 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) Pyr_redox_dim PF02852.22 ETO17443.1 - 9e-30 103.2 0.2 1.6e-29 102.4 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox_2 PF07992.14 ETO17443.1 - 8e-17 61.4 0.0 1.9e-16 60.2 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO17443.1 - 0.00094 18.5 0.0 0.0014 17.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase PTS_2-RNA PF01885.16 ETO17444.1 - 1.4e-41 142.5 1.4 2.7e-40 138.4 0.3 2.2 1 1 1 2 2 2 2 RNA 2'-phosphotransferase, Tpt1 / KptA family NUDIX PF00293.28 ETO17444.1 - 0.00041 20.4 0.0 0.00081 19.4 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain GATase PF00117.28 ETO17446.1 - 2.7e-53 180.6 0.1 9.7e-53 178.8 0.1 1.8 1 1 0 1 1 1 1 Glutamine amidotransferase class-I CTP_synth_N PF06418.14 ETO17446.1 - 1.9e-38 132.3 0.0 3e-38 131.7 0.0 1.2 1 0 0 1 1 1 1 CTP synthase N-terminus Peptidase_C26 PF07722.13 ETO17446.1 - 2e-06 27.7 0.1 2.2e-05 24.3 0.0 2.3 1 1 1 2 2 2 1 Peptidase C26 DUF2649 PF10854.8 ETO17447.1 - 0.13 12.6 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2649) DUF913 PF06025.12 ETO17450.1 - 0.069 12.1 2.0 0.086 11.8 2.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Chromo_2 PF18704.1 ETO17450.1 - 0.2 12.0 5.9 0.57 10.5 5.9 1.8 1 1 0 1 1 1 0 Chromatin organization modifier domain 2 Podoplanin PF05808.11 ETO17450.1 - 0.25 11.4 3.5 0.31 11.1 3.5 1.1 1 0 0 1 1 1 0 Podoplanin Ank_5 PF13857.6 ETO17451.1 - 7.7e-10 38.8 0.3 0.00016 21.9 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO17451.1 - 2.1e-07 31.0 0.0 3.7e-06 27.1 0.0 2.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO17451.1 - 3e-07 30.9 0.4 9.9e-07 29.3 0.1 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO17451.1 - 3.1e-05 24.4 0.0 5e-05 23.8 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO17451.1 - 4.1e-05 23.7 0.0 0.12 13.0 0.0 2.7 2 1 0 2 2 2 2 Ankyrin repeat WHEP-TRS PF00458.20 ETO17451.1 - 0.18 12.0 0.3 0.18 12.0 0.3 2.7 3 0 0 3 3 3 0 WHEP-TRS domain DUF2423 PF10338.9 ETO17453.1 - 0.029 14.6 1.2 0.13 12.5 1.2 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2423) Kinesin PF00225.23 ETO17456.1 - 4.5e-07 29.1 0.2 8.3e-07 28.2 0.0 1.5 2 0 0 2 2 2 1 Kinesin motor domain FTR PF01913.18 ETO17459.1 - 0.0048 16.8 5.9 0.0086 16.0 5.9 1.4 1 0 0 1 1 1 1 Formylmethanofuran-tetrahydromethanopterin formyltransferase FSA_C PF10479.9 ETO17459.1 - 0.12 10.5 11.2 0.14 10.2 11.2 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus mono-CXXC PF15626.6 ETO17459.1 - 0.61 10.5 3.4 3.8 7.9 0.2 2.5 2 0 0 2 2 2 0 single CXXC unit Med3 PF11593.8 ETO17459.1 - 7.4 5.6 22.7 9.9 5.2 22.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF349 PF03993.12 ETO17460.1 - 0.078 13.3 6.7 0.19 12.0 1.0 2.6 2 0 0 2 2 2 0 Domain of Unknown Function (DUF349) Actin PF00022.19 ETO17461.1 - 3e-12 45.9 0.0 4.3e-12 45.4 0.0 1.1 1 0 0 1 1 1 1 Actin zf-RING_2 PF13639.6 ETO17462.1 - 1.3e-06 28.7 3.8 1.9e-06 28.1 3.8 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ETO17462.1 - 8.9e-05 22.4 4.4 0.00015 21.7 4.4 1.4 1 0 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.7 ETO17462.1 - 0.0007 19.7 3.3 0.0013 18.8 3.3 1.5 1 0 0 1 1 1 1 RING-variant domain zf-C3HC4 PF00097.25 ETO17462.1 - 0.00089 19.1 3.6 0.0015 18.3 3.6 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO17462.1 - 0.00093 19.0 1.7 0.0017 18.2 1.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO17462.1 - 0.0017 18.6 2.1 0.0046 17.2 2.1 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ETO17462.1 - 0.024 14.4 5.2 0.041 13.6 5.2 1.4 1 0 0 1 1 1 0 RING-like zinc finger FANCL_C PF11793.8 ETO17462.1 - 0.057 13.6 2.1 0.13 12.5 2.1 1.6 1 0 0 1 1 1 0 FANCL C-terminal domain zf-RING_5 PF14634.6 ETO17462.1 - 0.062 13.3 2.9 0.099 12.6 2.9 1.3 1 0 0 1 1 1 0 zinc-RING finger domain Prok-RING_1 PF14446.6 ETO17462.1 - 0.1 12.5 1.1 0.2 11.6 1.1 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-ANAPC11 PF12861.7 ETO17462.1 - 0.12 12.5 0.3 0.21 11.7 0.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger GREB1 PF15782.5 ETO17462.1 - 7.1 3.6 10.7 9.6 3.2 10.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GH115_C PF17829.1 ETO17462.1 - 9.1 6.1 9.2 10 5.9 6.9 2.0 2 0 0 2 2 2 0 Gylcosyl hydrolase family 115 C-terminal domain DUF5617 PF18493.1 ETO17463.1 - 0.079 13.1 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5617) Fez1 PF06818.15 ETO17464.1 - 2e-05 25.1 24.7 3.3e-05 24.5 24.7 1.3 1 0 0 1 1 1 1 Fez1 DUF1664 PF07889.12 ETO17464.1 - 0.0085 16.1 0.2 0.0085 16.1 0.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO17464.1 - 0.018 15.6 0.0 0.018 15.6 0.0 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region Sec8_exocyst PF04048.14 ETO17464.1 - 0.028 14.3 3.7 0.085 12.7 0.1 2.5 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Fib_alpha PF08702.10 ETO17464.1 - 0.032 14.4 1.8 0.032 14.4 1.8 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family ING PF12998.7 ETO17464.1 - 0.04 14.5 2.5 0.04 14.5 2.5 2.6 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding Gp58 PF07902.11 ETO17464.1 - 0.12 10.6 0.5 0.21 9.8 0.5 1.3 1 0 0 1 1 1 0 gp58-like protein DEAD PF00270.29 ETO17464.1 - 0.14 11.9 0.5 0.28 10.9 0.4 1.5 1 1 0 1 1 1 0 DEAD/DEAH box helicase Spc7 PF08317.11 ETO17464.1 - 1.3 7.8 29.7 0.092 11.6 6.3 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein ARGLU PF15346.6 ETO17464.1 - 1.9 8.3 32.6 0.86 9.5 18.7 2.2 2 0 0 2 2 2 0 Arginine and glutamate-rich 1 Atg14 PF10186.9 ETO17464.1 - 7.7 5.5 24.9 20 4.1 24.9 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HMMR_N PF15905.5 ETO17464.1 - 9.4 5.6 29.8 0.23 10.9 7.8 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Sulfotransfer_3 PF13469.6 ETO17465.1 - 1.4e-14 55.0 0.4 3.9e-11 43.8 0.1 2.4 2 0 0 2 2 2 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 ETO17465.1 - 1.8e-05 24.3 0.1 5.6e-05 22.7 0.1 1.7 1 1 0 1 1 1 1 Sulfotransferase domain Pkinase PF00069.25 ETO17466.1 - 2.4e-61 207.4 0.8 4.3e-61 206.6 0.8 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17466.1 - 1.1e-35 123.2 2.0 2.5e-31 108.9 1.5 2.5 2 1 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO17466.1 - 6.4e-10 38.5 1.0 8e-10 38.2 1.0 1.1 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ETO17466.1 - 6.8e-05 22.5 2.0 0.00015 21.4 2.0 1.7 1 1 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 ETO17466.1 - 0.0018 17.6 1.6 0.0046 16.3 0.6 1.9 2 1 0 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ETO17466.1 - 0.0021 16.9 1.8 0.0026 16.6 0.6 1.5 1 1 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 ETO17466.1 - 0.0022 17.6 0.4 0.0038 16.8 0.4 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ETO17466.1 - 0.0039 17.1 0.1 0.0061 16.5 0.1 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO17466.1 - 0.031 13.6 0.1 0.052 12.9 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Cystatin PF00031.21 ETO17466.1 - 0.13 12.6 0.0 0.29 11.4 0.0 1.6 1 0 0 1 1 1 0 Cystatin domain Lin-8 PF03353.15 ETO17467.1 - 5 6.6 24.3 8.2 5.9 24.3 1.3 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist OsmC PF02566.19 ETO17468.1 - 9.9e-06 26.0 0.0 1.4e-05 25.5 0.0 1.1 1 0 0 1 1 1 1 OsmC-like protein Sec2p PF06428.11 ETO17469.1 - 0.01 15.8 7.9 0.01 15.8 7.9 2.9 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Ntox23 PF15528.6 ETO17469.1 - 0.016 15.4 0.9 0.023 14.9 0.9 1.3 1 0 0 1 1 1 0 Bacterial toxin 23 GAS PF13851.6 ETO17469.1 - 0.029 13.7 27.3 0.039 13.3 27.3 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding FapA PF03961.13 ETO17469.1 - 0.031 12.9 17.2 0.036 12.7 17.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A PCRF PF03462.18 ETO17469.1 - 0.036 13.9 14.6 0.046 13.6 14.6 1.2 1 0 0 1 1 1 0 PCRF domain KASH_CCD PF14662.6 ETO17469.1 - 0.12 12.2 25.8 0.16 11.8 25.8 1.2 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Uso1_p115_C PF04871.13 ETO17469.1 - 0.21 12.0 27.0 0.21 12.0 24.0 1.9 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region KELK PF15796.5 ETO17469.1 - 0.22 12.0 23.6 0.18 12.3 10.6 2.3 1 1 1 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Dabb PF07876.12 ETO17469.1 - 0.26 11.9 3.1 0.48 11.1 2.5 1.9 1 1 1 2 2 2 0 Stress responsive A/B Barrel Domain PNKP_ligase PF16542.5 ETO17469.1 - 0.26 10.7 6.1 0.29 10.6 6.1 1.1 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, ligase domain BLOC1_2 PF10046.9 ETO17469.1 - 0.3 11.4 21.9 2.6 8.4 3.5 3.0 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Prefoldin_3 PF13758.6 ETO17469.1 - 0.31 11.1 10.8 0.093 12.8 5.4 2.1 1 1 2 3 3 3 0 Prefoldin subunit DUF3037 PF11236.8 ETO17469.1 - 0.42 11.0 3.7 0.63 10.5 3.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3037) Atg14 PF10186.9 ETO17469.1 - 0.44 9.6 15.2 0.55 9.3 15.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Mod_r PF07200.13 ETO17469.1 - 0.66 10.1 25.7 0.24 11.5 22.4 1.7 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein ERM PF00769.19 ETO17469.1 - 1.1 9.1 28.8 2.1 8.1 28.1 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Golgin_A5 PF09787.9 ETO17469.1 - 1.1 8.7 23.7 1.3 8.4 23.7 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 ATP-grasp_4 PF13535.6 ETO17469.1 - 1.8 8.1 6.8 1 8.9 2.2 2.2 1 1 1 2 2 2 0 ATP-grasp domain Oleosin PF01277.17 ETO17469.1 - 2.1 8.2 4.9 18 5.1 0.2 2.5 2 1 1 3 3 3 0 Oleosin UPF0242 PF06785.11 ETO17469.1 - 2.3 8.3 28.4 1.9 8.6 11.1 2.0 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4047 PF13256.6 ETO17469.1 - 2.8 8.1 14.8 4.8 7.4 13.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) Seryl_tRNA_N PF02403.22 ETO17469.1 - 3.1 8.1 19.1 0.39 11.0 13.5 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain COG2 PF06148.11 ETO17469.1 - 3.2 7.8 13.5 0.56 10.3 2.0 2.5 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Spc7 PF08317.11 ETO17469.1 - 3.5 6.4 27.1 0.31 9.9 14.9 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein YtxH PF12732.7 ETO17469.1 - 3.5 8.2 13.9 6.1 7.5 5.2 2.5 2 1 1 3 3 2 0 YtxH-like protein ACR_tran PF00873.19 ETO17469.1 - 4.3 4.8 12.5 4.8 4.7 12.5 1.0 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family Exonuc_VII_L PF02601.15 ETO17469.1 - 4.6 6.7 17.6 5.3 6.5 17.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2381 PF09544.10 ETO17469.1 - 5.4 6.5 10.2 3.2 7.2 2.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2381) HSP70 PF00012.20 ETO17469.1 - 6.2 4.9 17.8 7 4.7 17.8 1.0 1 0 0 1 1 1 0 Hsp70 protein DUF4407 PF14362.6 ETO17469.1 - 6.3 6.0 19.8 7.1 5.9 19.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 ETO17469.1 - 8.3 6.9 26.5 19 5.8 26.4 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region HisKA_3 PF07730.13 ETO17469.1 - 9.5 6.8 9.3 16 6.1 0.8 2.8 1 1 2 3 3 3 0 Histidine kinase V_ATPase_I PF01496.19 ETO17469.1 - 9.8 3.9 17.8 11 3.8 17.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CAP_GLY PF01302.25 ETO17470.1 - 1e-07 31.8 0.1 2.6e-07 30.5 0.1 1.7 1 1 0 1 1 1 1 CAP-Gly domain YtkA PF13115.6 ETO17473.1 - 0.72 10.5 4.2 0.41 11.3 1.7 1.9 2 0 0 2 2 2 0 YtkA-like EssA PF10661.9 ETO17473.1 - 1.6 8.6 9.5 0.23 11.3 3.9 2.3 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA RmuC PF02646.16 ETO17474.1 - 9.9e-44 149.6 16.2 2.2e-41 141.9 0.4 3.5 3 0 0 3 3 3 2 RmuC family LapA_dom PF06305.11 ETO17474.1 - 0.059 13.2 0.4 4.3 7.2 0.0 2.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain DUF2232 PF09991.9 ETO17474.1 - 1.3 8.1 4.3 1 8.5 1.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2232) Carb_kinase PF01256.17 ETO17475.1 - 4.8e-48 163.8 0.0 5.5e-48 163.6 0.0 1.0 1 0 0 1 1 1 1 Carbohydrate kinase HK PF02110.15 ETO17475.1 - 1.5e-07 31.1 0.0 2.8e-07 30.2 0.0 1.5 1 1 0 1 1 1 1 Hydroxyethylthiazole kinase family Phos_pyr_kin PF08543.12 ETO17475.1 - 2.3e-05 23.9 0.1 9.6e-05 21.9 0.1 2.0 1 1 0 1 1 1 1 Phosphomethylpyrimidine kinase SAM_1 PF00536.30 ETO17477.1 - 0.00082 19.8 0.6 0.0018 18.6 0.2 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO17477.1 - 0.0014 18.7 0.4 0.004 17.2 0.1 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) DUF4515 PF14988.6 ETO17477.1 - 0.025 14.4 2.1 0.045 13.6 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) DUF4377 PF14302.6 ETO17477.1 - 0.11 12.6 0.6 0.15 12.2 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4377) PDZ PF00595.24 ETO17478.1 - 0.00072 19.9 0.1 0.0014 19.0 0.1 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO17478.1 - 0.14 12.1 0.0 0.31 10.9 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DUF2076 PF09849.9 ETO17478.1 - 4.3 7.3 11.5 6.1 6.8 11.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Secretin_N_2 PF07655.13 ETO17478.1 - 4.9 7.8 11.9 11 6.7 11.9 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain RAI16-like PF10257.9 ETO17481.1 - 0.016 14.1 0.6 0.017 14.0 0.6 1.1 1 0 0 1 1 1 0 Retinoic acid induced 16-like protein Prot_ATP_ID_OB PF16450.5 ETO17482.1 - 1.4e-10 40.9 0.0 2.7e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA PF00004.29 ETO17482.1 - 0.014 15.8 0.6 0.74 10.3 0.2 2.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ETO17483.1 - 7.2e-34 117.1 0.2 1.7e-33 115.8 0.1 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO17483.1 - 2.9e-08 33.4 0.1 6e-08 32.4 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ETO17483.1 - 0.0035 17.5 0.0 0.0062 16.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) Folate_carrier PF01770.18 ETO17485.1 - 0.00066 18.5 3.4 0.00084 18.2 3.4 1.1 1 0 0 1 1 1 1 Reduced folate carrier DEAD_2 PF06733.15 ETO17485.1 - 0.0019 17.8 0.1 0.0042 16.7 0.1 1.5 1 1 0 1 1 1 1 DEAD_2 DUF5618 PF18498.1 ETO17486.1 - 0.008 16.4 2.5 0.008 16.4 2.5 4.4 4 1 0 4 4 4 1 Domain of unknown function (DUF5618) CP12 PF02672.15 ETO17486.1 - 7.2 7.4 30.8 3.4 8.5 6.0 5.2 3 1 1 4 4 4 0 CP12 domain Tubulin PF00091.25 ETO17487.1 - 5.1e-62 209.6 0.6 2e-61 207.7 0.1 2.1 3 0 0 3 3 3 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO17487.1 - 9e-28 97.0 0.1 1.8e-27 96.0 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO17487.1 - 0.1 12.9 0.1 0.35 11.2 0.0 1.9 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ETO17487.1 - 0.11 11.6 0.0 0.2 10.8 0.0 1.3 1 0 0 1 1 1 0 Tubulin like WD40 PF00400.32 ETO17488.1 - 5.8e-63 207.3 22.1 4.2e-10 40.0 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17488.1 - 4e-21 75.1 3.2 0.0013 19.0 0.2 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17488.1 - 3.7e-17 62.3 2.8 0.01 14.8 0.1 6.6 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO17488.1 - 1.2e-12 48.1 2.0 0.00035 20.5 0.2 3.6 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO17488.1 - 6.5e-12 45.4 2.4 0.011 15.1 0.2 4.2 2 2 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO17488.1 - 2.8e-11 42.8 13.6 0.0016 17.2 0.1 6.6 2 2 4 6 6 6 5 Nucleoporin Nup120/160 Utp8 PF10395.9 ETO17488.1 - 4.6e-05 22.1 0.1 0.007 14.9 0.0 2.9 1 1 2 3 3 3 1 Utp8 family Cytochrom_D1 PF02239.16 ETO17488.1 - 0.00016 20.4 1.3 0.85 8.1 0.1 3.3 1 1 2 3 3 3 2 Cytochrome D1 heme domain DUF1513 PF07433.11 ETO17488.1 - 0.00032 19.9 0.2 1.6 7.7 0.0 4.0 2 2 2 4 4 4 2 Protein of unknown function (DUF1513) PD40 PF07676.12 ETO17488.1 - 0.00033 20.5 0.5 4.1 7.5 0.0 4.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Ricin_B_lectin PF00652.22 ETO17488.1 - 0.041 14.1 6.8 0.65 10.3 0.2 3.1 1 1 2 3 3 3 0 Ricin-type beta-trefoil lectin domain HARP PF07443.13 ETO17488.1 - 0.13 12.0 1.0 1.8 8.2 0.0 3.3 5 0 0 5 5 5 0 HepA-related protein (HARP) RRN3 PF05327.11 ETO17490.1 - 0.82 8.1 2.5 0.94 7.9 2.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FAM176 PF14851.6 ETO17490.1 - 3.2 7.4 5.2 4.9 6.8 5.2 1.3 1 0 0 1 1 1 0 FAM176 family DUF2956 PF11169.8 ETO17490.1 - 9.6 6.5 8.6 16 5.8 8.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Hexapep PF00132.24 ETO17491.1 - 6.9e-13 47.8 10.3 1.8e-05 24.2 1.7 3.6 2 1 1 3 3 3 3 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ETO17491.1 - 1.4e-11 44.0 10.6 1.3e-10 40.9 0.5 3.6 2 1 1 3 3 3 2 Hexapeptide repeat of succinyl-transferase G-alpha PF00503.20 ETO17492.1 - 1.2e-07 31.3 0.1 1.4e-07 31.0 0.1 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Rad17 PF03215.15 ETO17492.1 - 0.0035 17.3 0.1 0.0046 16.9 0.1 1.3 1 1 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 ETO17492.1 - 0.012 16.1 0.1 0.018 15.5 0.1 1.3 1 0 0 1 1 1 0 ABC transporter NB-ARC PF00931.22 ETO17492.1 - 0.015 14.5 1.1 0.015 14.5 0.1 1.4 2 0 0 2 2 2 0 NB-ARC domain MCM PF00493.23 ETO17492.1 - 0.027 13.6 0.0 0.036 13.2 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain TniB PF05621.11 ETO17492.1 - 0.029 13.8 0.1 0.029 13.8 0.1 1.3 1 1 0 1 1 1 0 Bacterial TniB protein AAA_5 PF07728.14 ETO17492.1 - 0.058 13.4 0.2 0.098 12.7 0.2 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_24 PF13479.6 ETO17492.1 - 0.059 13.1 0.3 0.083 12.6 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ETO17492.1 - 0.059 13.2 0.0 0.078 12.8 0.0 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system TsaE PF02367.17 ETO17492.1 - 0.064 13.3 0.2 0.11 12.5 0.2 1.4 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_29 PF13555.6 ETO17492.1 - 0.071 12.9 0.0 0.11 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arf PF00025.21 ETO17492.1 - 0.12 11.8 1.0 0.17 11.4 0.1 1.6 2 0 0 2 2 2 0 ADP-ribosylation factor family WD40 PF00400.32 ETO17493.1 - 0.0058 17.4 1.8 0.02 15.7 0.1 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17493.1 - 0.059 13.7 0.3 0.8 10.0 0.1 2.5 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain OTOS PF15182.6 ETO17494.1 - 0.15 12.0 1.3 0.51 10.3 0.3 2.3 2 0 0 2 2 2 0 Otospiralin WT1 PF02165.15 ETO17496.1 - 0.06 12.6 0.2 0.074 12.3 0.2 1.2 1 0 0 1 1 1 0 Wilm's tumour protein G-alpha PF00503.20 ETO17497.1 - 2.8e-23 82.6 0.9 3.8e-23 82.2 0.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO17497.1 - 0.00038 21.0 0.5 0.00049 20.6 0.4 1.3 1 1 0 1 1 1 1 ABC transporter Arf PF00025.21 ETO17497.1 - 0.0013 18.2 0.1 0.0021 17.5 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO17497.1 - 0.027 14.7 0.2 0.061 13.6 0.2 1.9 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO17497.1 - 0.027 14.5 0.2 0.039 14.0 0.2 1.6 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ETO17497.1 - 0.03 14.1 0.0 0.054 13.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRPRB PF09439.10 ETO17497.1 - 0.041 13.3 0.1 0.087 12.2 0.0 1.5 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit TrwB_AAD_bind PF10412.9 ETO17497.1 - 0.052 12.5 1.5 0.31 9.9 0.3 2.1 1 1 0 2 2 2 0 Type IV secretion-system coupling protein DNA-binding domain AAA_28 PF13521.6 ETO17497.1 - 0.087 13.1 0.3 0.17 12.1 0.2 1.7 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO17497.1 - 0.1 13.2 0.1 0.17 12.4 0.1 1.4 1 0 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ETO17497.1 - 0.11 11.6 1.3 0.27 10.4 1.3 1.7 1 1 0 1 1 1 0 NB-ARC domain Noc2 PF03715.13 ETO17499.1 - 4.9e-19 68.7 5.3 9.3e-19 67.8 5.3 1.4 1 1 0 1 1 1 1 Noc2p family DUF4972 PF16342.5 ETO17499.1 - 0.053 13.2 0.4 0.13 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) Noc2 PF03715.13 ETO17500.1 - 2.2e-25 89.5 3.9 1.9e-24 86.5 4.0 2.0 1 1 0 1 1 1 1 Noc2p family CobT PF06213.12 ETO17500.1 - 0.014 14.8 1.2 0.014 14.8 1.2 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Vfa1 PF08432.10 ETO17500.1 - 0.017 15.5 1.7 0.017 15.5 1.7 2.4 2 1 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO17500.1 - 0.032 14.0 0.0 0.032 14.0 0.0 2.7 2 1 0 2 2 2 0 Connexin Presenilin PF01080.17 ETO17500.1 - 1.1 8.0 23.5 0.32 9.7 1.8 2.1 2 0 0 2 2 2 0 Presenilin Neur_chan_memb PF02932.16 ETO17500.1 - 4.9 7.1 16.4 2.4 8.2 0.7 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Pox_Ag35 PF03286.14 ETO17500.1 - 6.8 6.4 30.5 0.47 10.2 6.9 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO17501.1 - 0.14 11.4 7.4 0.2 11.0 7.4 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO17501.1 - 0.79 10.1 12.4 1.6 9.2 12.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FYDLN_acid PF09538.10 ETO17501.1 - 0.97 10.1 13.0 0.54 11.0 10.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) PBP1_TM PF14812.6 ETO17501.1 - 1 9.8 10.4 1.8 9.0 10.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WD40 PF00400.32 ETO17503.1 - 2.4e-05 25.0 2.0 0.022 15.6 0.0 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Sporozoite_P67 PF05642.11 ETO17503.1 - 0.045 11.9 9.5 0.053 11.6 1.5 2.1 2 0 0 2 2 2 0 Sporozoite P67 surface antigen NST1 PF13945.6 ETO17503.1 - 4 7.5 19.8 0.67 10.0 7.1 2.1 2 0 0 2 2 2 0 Salt tolerance down-regulator XAP5 PF04921.14 ETO17503.1 - 8.3 6.2 15.9 4.8 6.9 0.7 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator Porin_3 PF01459.22 ETO17504.1 - 0.00013 21.5 0.0 0.00044 19.8 0.0 1.8 1 1 0 1 1 1 1 Eukaryotic porin CDC45 PF02724.14 ETO17505.1 - 0.0044 15.4 11.5 0.0052 15.2 11.5 1.1 1 0 0 1 1 1 1 CDC45-like protein FmiP_Thoc5 PF09766.9 ETO17505.1 - 0.013 14.8 9.1 0.018 14.3 9.1 1.2 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 CAC1F_C PF16885.5 ETO17505.1 - 0.02 14.6 7.5 0.026 14.2 7.5 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term RRN3 PF05327.11 ETO17505.1 - 0.029 12.9 9.1 0.034 12.7 9.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SDA1 PF05285.12 ETO17505.1 - 0.036 13.5 12.6 0.047 13.1 12.6 1.3 1 0 0 1 1 1 0 SDA1 D123 PF07065.14 ETO17505.1 - 0.091 11.9 4.8 0.12 11.5 4.8 1.3 1 0 0 1 1 1 0 D123 DUF2052 PF09747.9 ETO17505.1 - 0.094 12.8 14.8 0.14 12.2 14.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Pox_Ag35 PF03286.14 ETO17505.1 - 0.15 11.8 13.6 0.14 11.9 11.1 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ETO17505.1 - 0.59 9.8 13.2 0.11 12.2 9.5 1.6 2 0 0 2 2 2 0 FAM176 family Lin-8 PF03353.15 ETO17505.1 - 0.88 9.1 13.3 1.2 8.7 13.3 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Vfa1 PF08432.10 ETO17505.1 - 1.2 9.4 11.2 1.8 8.9 11.2 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PBP1_TM PF14812.6 ETO17505.1 - 3 8.3 11.0 0.59 10.5 6.6 2.1 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO17505.1 - 3.6 6.8 9.2 6.4 6.0 9.2 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO17505.1 - 5 5.1 13.7 5.6 4.9 13.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Astro_capsid_p PF12226.8 ETO17505.1 - 6.6 5.8 10.4 9.6 5.3 10.4 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF4637 PF15470.6 ETO17505.1 - 8.6 6.1 15.5 4.2 7.1 13.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Cytokin_check_N PF10407.9 ETO17506.1 - 0.038 13.9 1.2 0.08 12.9 1.2 1.5 1 1 0 1 1 1 0 Cdc14 phosphatase binding protein N-terminus SH3_1 PF00018.28 ETO17507.1 - 6.7e-25 86.4 5.6 5.3e-13 48.4 0.6 2.6 2 1 0 2 2 2 2 SH3 domain SH3_9 PF14604.6 ETO17507.1 - 3.2e-20 71.7 2.5 5.1e-09 35.8 0.1 2.3 2 0 0 2 2 2 2 Variant SH3 domain SH3_2 PF07653.17 ETO17507.1 - 3.8e-19 68.1 0.2 8e-10 38.3 0.0 2.2 2 0 0 2 2 2 2 Variant SH3 domain VHP PF02209.19 ETO17507.1 - 1.4e-16 60.2 0.2 2.8e-16 59.3 0.2 1.5 1 0 0 1 1 1 1 Villin headpiece domain DUF3104 PF11302.8 ETO17507.1 - 0.022 14.5 0.7 3.8 7.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) Mucin PF01456.17 ETO17507.1 - 0.09 12.8 13.0 0.13 12.3 13.0 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FH2 PF02181.23 ETO17508.1 - 3.3e-09 36.3 5.0 3.3e-09 36.3 5.0 1.6 2 0 0 2 2 2 1 Formin Homology 2 Domain CRT-like PF08627.10 ETO17508.1 - 0.023 13.7 0.1 0.032 13.2 0.1 1.1 1 0 0 1 1 1 0 CRT-like, chloroquine-resistance transporter-like rpo30_N PF12410.8 ETO17509.1 - 0.06 13.3 0.9 0.099 12.6 0.9 1.5 1 1 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit DDHD PF02862.17 ETO17509.1 - 0.18 11.9 4.7 0.22 11.6 4.7 1.2 1 0 0 1 1 1 0 DDHD domain NPBW PF15180.6 ETO17509.1 - 0.53 10.2 4.2 0.41 10.5 2.3 1.8 2 1 0 2 2 2 0 Neuropeptides B and W RR_TM4-6 PF06459.12 ETO17509.1 - 0.87 9.4 9.9 1.2 8.9 9.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 MAJIN PF15077.6 ETO17509.1 - 1.4 8.7 9.2 1.8 8.3 9.2 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein Presenilin PF01080.17 ETO17509.1 - 1.5 7.5 9.3 1.8 7.3 9.3 1.1 1 0 0 1 1 1 0 Presenilin AAA_11 PF13086.6 ETO17509.1 - 1.8 8.3 12.4 2.4 7.9 12.4 1.2 1 0 0 1 1 1 0 AAA domain MDFI PF15316.6 ETO17509.1 - 2 8.5 6.7 3.1 7.9 6.7 1.5 1 0 0 1 1 1 0 MyoD family inhibitor Zip PF02535.22 ETO17509.1 - 4.7 6.3 5.8 5.5 6.1 5.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter zf-TRAF PF02176.18 ETO17510.1 - 7.1e-06 26.6 8.0 1e-05 26.1 6.1 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger FAM76 PF16046.5 ETO17511.1 - 0.012 15.0 14.3 0.012 15.0 14.3 1.9 1 1 1 2 2 2 0 FAM76 protein HAND PF09110.11 ETO17511.1 - 0.93 10.3 13.5 2.4 8.9 13.5 1.7 1 1 0 1 1 1 0 HAND WD40 PF00400.32 ETO17512.1 - 0.0034 18.2 0.6 0.02 15.7 0.2 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat TetM_leader PF08076.11 ETO17512.1 - 0.097 12.5 1.3 0.35 10.7 1.3 2.0 1 0 0 1 1 1 0 Tetracycline resistance determinant leader peptide DUF1418 PF07214.12 ETO17512.1 - 0.12 12.3 0.5 0.18 11.7 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) DUF4389 PF14333.6 ETO17512.1 - 7 6.7 7.6 3.5 7.6 1.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4389) FAM176 PF14851.6 ETO17513.1 - 0.0018 17.9 7.7 0.012 15.2 0.8 2.2 2 0 0 2 2 2 2 FAM176 family Peptidase_S49_N PF08496.10 ETO17513.1 - 0.012 15.7 2.6 0.012 15.7 2.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Ctr PF04145.15 ETO17513.1 - 0.032 14.9 1.6 0.067 13.8 1.6 1.6 1 1 0 1 1 1 0 Ctr copper transporter family SID-1_RNA_chan PF13965.6 ETO17513.1 - 0.047 12.1 0.1 0.047 12.1 0.1 1.5 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 DUF2070 PF09843.9 ETO17513.1 - 0.096 11.0 0.0 0.13 10.6 0.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Neur_chan_memb PF02932.16 ETO17513.1 - 0.14 12.2 0.3 0.23 11.5 0.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1754 PF08555.10 ETO17513.1 - 0.2 12.5 20.8 0.34 11.7 4.7 2.6 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Eapp_C PF10238.9 ETO17513.1 - 0.25 11.4 7.4 3.3 7.8 0.9 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein NEMP PF10225.9 ETO17513.1 - 0.26 10.9 3.7 0.36 10.5 0.2 2.1 2 0 0 2 2 2 0 NEMP family Rib_recp_KP_reg PF05104.12 ETO17513.1 - 0.37 11.8 24.5 0.057 14.5 7.0 2.3 2 0 0 2 2 2 0 Ribosome receptor lysine/proline rich region Cytadhesin_P30 PF07271.11 ETO17513.1 - 1.1 8.8 3.3 2.1 7.8 3.3 1.4 1 0 0 1 1 1 0 Cytadhesin P30/P32 OAD_gamma PF04277.13 ETO17513.1 - 1.4 9.5 18.6 20 5.9 0.4 3.3 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain RPA43_OB PF17875.1 ETO17513.1 - 3.1 8.5 7.8 6.5 7.4 1.0 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I EMC3_TMCO1 PF01956.16 ETO17513.1 - 4.2 7.1 7.5 0.59 9.8 1.1 2.1 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like PP2C PF00481.21 ETO17514.1 - 5.7e-16 58.9 3.7 7.6e-11 42.1 0.1 2.1 1 1 0 2 2 2 2 Protein phosphatase 2C Acyl-CoA_ox_N PF14749.6 ETO17515.1 - 0.36 11.4 3.9 0.14 12.7 0.8 1.9 2 0 0 2 2 2 0 Acyl-coenzyme A oxidase N-terminal Methyltransf_14 PF08484.11 ETO17515.1 - 0.6 9.9 2.8 4.1 7.2 0.2 2.2 2 0 0 2 2 2 0 C-methyltransferase C-terminal domain YqzE PF14038.6 ETO17517.1 - 2.5 8.1 9.0 1.2 9.1 0.1 3.0 2 1 0 2 2 2 0 YqzE-like protein Glutaredoxin PF00462.24 ETO17519.1 - 1.3e-05 25.4 0.1 2.6e-05 24.4 0.0 1.6 2 0 0 2 2 2 1 Glutaredoxin Pkinase PF00069.25 ETO17520.1 - 1.6e-25 90.0 0.0 2.1e-25 89.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17520.1 - 3e-06 26.7 0.0 7.4e-06 25.4 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Mgm101p PF06420.12 ETO17520.1 - 0.1 12.1 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial genome maintenance MGM101 Glyco_transf_49 PF13896.6 ETO17521.1 - 5.4e-12 45.7 0.0 5.4e-12 45.7 0.0 1.4 2 0 0 2 2 2 1 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 ETO17521.1 - 0.0048 16.7 0.0 0.01 15.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferase family 2 DUF4752 PF15944.5 ETO17521.1 - 0.033 14.2 0.5 0.086 12.9 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4752) RsmJ PF04378.13 ETO17522.1 - 0.068 12.4 0.1 0.15 11.3 0.1 1.5 1 0 0 1 1 1 0 Ribosomal RNA large subunit methyltransferase D, RlmJ DUF1694 PF07997.11 ETO17522.1 - 3.1 7.9 9.7 22 5.2 0.2 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF1694) AAA_5 PF07728.14 ETO17522.1 - 7.1 6.6 8.2 22 5.1 2.7 3.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) YMF19 PF02326.15 ETO17523.1 - 0.15 12.9 4.1 0.44 11.4 0.2 3.3 3 2 0 3 3 3 0 Plant ATP synthase F0 WBP-1 PF11669.8 ETO17523.1 - 0.25 12.0 0.2 0.25 12.0 0.2 2.7 3 0 0 3 3 3 0 WW domain-binding protein 1 CENP-F_leu_zip PF10473.9 ETO17523.1 - 2.9 7.9 19.9 0.019 15.0 3.9 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 ETO17523.1 - 5.6 7.5 30.4 0.45 11.1 10.0 3.2 2 1 0 3 3 3 0 Apg6 coiled-coil region UCMA PF17085.5 ETO17524.1 - 0.056 13.5 0.2 0.097 12.7 0.2 1.4 1 0 0 1 1 1 0 Unique cartilage matrix associated protein UspB PF10625.9 ETO17524.1 - 0.074 13.0 0.1 0.18 11.8 0.1 1.6 1 0 0 1 1 1 0 Universal stress protein B (UspB) DUF1229 PF06797.11 ETO17524.1 - 0.081 13.1 0.1 0.12 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1229) FapA PF03961.13 ETO17525.1 - 0.31 9.6 3.2 0.69 8.5 3.2 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 ETO17525.1 - 0.42 10.8 11.6 0.1 12.8 1.4 3.2 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family DUF4446 PF14584.6 ETO17525.1 - 0.67 9.9 7.1 1.5 8.8 1.4 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) XhlA PF10779.9 ETO17525.1 - 0.88 9.8 7.0 3.3 8.0 7.0 2.1 1 0 0 1 1 1 0 Haemolysin XhlA TolA_bind_tri PF16331.5 ETO17525.1 - 1.2 9.3 6.0 0.41 10.8 2.3 2.2 2 0 0 2 2 2 0 TolA binding protein trimerisation SlyX PF04102.12 ETO17525.1 - 9 7.0 8.4 5.1 7.8 5.4 2.2 2 0 0 2 2 2 0 SlyX RyR PF02026.16 ETO17526.1 - 3.8e-12 46.2 0.0 5e-09 36.2 0.0 2.3 2 0 0 2 2 2 2 RyR domain WD40 PF00400.32 ETO17527.1 - 3.8e-06 27.5 0.1 7e-06 26.7 0.1 1.4 1 0 0 1 1 1 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17527.1 - 0.016 15.5 0.0 0.021 15.1 0.0 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WES_acyltransf PF03007.16 ETO17528.1 - 1.1e-05 25.4 0.0 0.1 12.4 0.0 2.1 2 0 0 2 2 2 2 Wax ester synthase-like Acyl-CoA acyltransferase domain CDC45 PF02724.14 ETO17529.1 - 0.049 11.9 14.8 0.078 11.3 14.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO17529.1 - 0.07 12.3 0.2 0.09 12.0 0.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter TFIIA PF03153.13 ETO17529.1 - 0.47 10.4 18.7 0.19 11.7 16.7 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sigma70_ner PF04546.13 ETO17529.1 - 0.56 10.1 16.0 0.18 11.7 11.2 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF3543 PF12063.8 ETO17529.1 - 0.62 9.4 15.5 1.1e+02 2.0 15.5 2.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3543) NOA36 PF06524.12 ETO17529.1 - 0.63 9.3 21.8 1.2 8.4 21.8 1.5 1 0 0 1 1 1 0 NOA36 protein DUF2076 PF09849.9 ETO17529.1 - 1.2 9.1 18.2 2.7 8.0 18.2 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) TRAP_alpha PF03896.16 ETO17529.1 - 1.4 8.1 7.9 2.7 7.1 7.9 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit YL1 PF05764.13 ETO17529.1 - 5.5 7.0 19.4 0.25 11.4 13.5 1.8 2 0 0 2 2 2 0 YL1 nuclear protein Cwf_Cwc_15 PF04889.12 ETO17529.1 - 7.4 6.2 37.6 23 4.6 37.6 1.9 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Skp1 PF01466.19 ETO17530.1 - 2.8e-26 91.4 0.2 2.8e-26 91.4 0.2 2.0 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETO17530.1 - 5.2e-06 26.6 0.0 1.7e-05 24.9 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, tetramerisation domain BTB PF00651.31 ETO17530.1 - 0.0086 16.3 0.7 0.046 14.0 0.7 2.0 1 1 0 1 1 1 1 BTB/POZ domain Myb_DNA-binding PF00249.31 ETO17530.1 - 0.058 13.6 0.1 1.8 8.8 0.0 2.6 2 0 0 2 2 2 0 Myb-like DNA-binding domain FAD-oxidase_C PF02913.19 ETO17531.1 - 9.9e-55 185.9 0.0 1.2e-54 185.6 0.0 1.1 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ETO17531.1 - 1.5e-11 44.2 0.2 2.7e-11 43.4 0.2 1.5 1 0 0 1 1 1 1 FAD binding domain DUF3556 PF12077.8 ETO17532.1 - 0.051 12.0 0.4 0.079 11.4 0.3 1.4 1 1 0 1 1 1 0 Transmembrane protein of unknown function (DUF3556) Glyco_hydro_75 PF07335.11 ETO17532.1 - 0.39 11.0 2.6 1.4 9.2 0.4 2.1 2 1 0 2 2 2 0 Fungal chitosanase of glycosyl hydrolase group 75 Jnk-SapK_ap_N PF09744.9 ETO17532.1 - 0.61 10.3 10.1 0.9 9.8 10.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 SAM_2 PF07647.17 ETO17533.1 - 1.5e-15 57.0 0.5 1.6e-08 34.6 0.0 2.1 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO17533.1 - 2.7e-09 37.3 0.4 0.0003 21.2 0.0 2.2 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) DIL PF01843.19 ETO17533.1 - 0.076 13.3 0.1 0.15 12.4 0.0 1.7 2 0 0 2 2 2 0 DIL domain TPR_2 PF07719.17 ETO17534.1 - 6e-17 60.3 16.6 0.0041 17.1 0.3 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17534.1 - 2.4e-16 58.8 16.4 0.0012 18.6 0.4 8.1 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17534.1 - 5.4e-12 45.8 5.9 0.0018 18.5 0.4 6.0 2 2 2 5 5 5 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17534.1 - 1.1e-11 45.0 0.2 0.0002 21.8 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17534.1 - 2.6e-11 43.0 0.6 0.0015 18.1 0.1 5.6 6 0 0 6 6 6 2 TPR repeat TPR_17 PF13431.6 ETO17534.1 - 2.6e-10 39.9 5.0 2 9.0 0.0 6.6 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17534.1 - 9e-10 38.0 14.1 0.023 14.9 0.4 7.8 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17534.1 - 1.9e-07 31.3 0.0 0.054 14.3 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17534.1 - 4.7e-07 29.9 4.7 0.013 15.7 0.4 4.1 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO17534.1 - 3.2e-06 27.7 0.0 0.35 11.6 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17534.1 - 6.5e-06 25.8 0.4 3 8.1 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17534.1 - 0.00029 21.3 1.8 20 6.1 0.0 5.8 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO17534.1 - 0.00062 19.9 0.0 0.37 11.0 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17534.1 - 0.0073 16.2 5.5 2.6 8.0 0.1 4.9 6 0 0 6 6 5 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO17534.1 - 0.02 15.0 3.9 0.43 10.7 0.1 4.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 ETO17534.1 - 0.027 13.7 0.1 0.94 8.6 0.0 3.0 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO17534.1 - 2.1 8.4 7.8 2.9 8.0 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat BSP_II PF05432.11 ETO17534.1 - 3.7 7.2 47.1 0.035 13.8 9.4 2.4 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Kelch_6 PF13964.6 ETO17535.1 - 0.0038 17.5 0.3 0.024 14.9 0.1 2.3 2 1 1 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO17535.1 - 0.13 12.2 0.9 1.5 8.9 0.1 2.4 2 0 0 2 2 2 0 Kelch motif B56 PF01603.20 ETO17536.1 - 1.4e-102 343.8 6.5 1.6e-102 343.6 6.5 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Lipase_3 PF01764.25 ETO17538.1 - 4.6e-08 33.0 0.0 7.5e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) Wax2_C PF12076.8 ETO17538.1 - 0.092 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 WAX2 C-terminal domain Abhydrolase_6 PF12697.7 ETO17538.1 - 0.12 12.9 0.0 0.14 12.7 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family NOG1_N PF17835.1 ETO17539.1 - 9.1e-34 116.7 1.7 2.2e-33 115.5 0.1 2.5 3 0 0 3 3 3 1 NOG1 N-terminal helical domain NOGCT PF08155.11 ETO17539.1 - 4.8e-23 80.9 1.2 1.1e-22 79.7 1.2 1.6 1 0 0 1 1 1 1 NOGCT (NUC087) domain MMR_HSR1 PF01926.23 ETO17539.1 - 6.2e-15 55.3 0.0 1.8e-14 53.8 0.0 1.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase FeoB_N PF02421.18 ETO17539.1 - 1e-12 47.9 0.1 3.3e-11 42.9 0.1 2.3 1 1 0 1 1 1 1 Ferrous iron transport protein B NOG1 PF06858.14 ETO17539.1 - 2.5e-07 30.4 2.8 0.0037 17.0 0.1 2.7 1 1 1 2 2 2 2 Nucleolar GTP-binding protein 1 (NOG1) RsgA_GTPase PF03193.16 ETO17539.1 - 0.0032 17.4 0.1 0.31 10.9 0.0 2.8 2 1 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ETO17539.1 - 0.0052 16.3 0.1 0.065 12.8 0.1 2.6 2 1 1 3 3 3 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ETO17539.1 - 0.021 14.3 0.0 1.9 7.9 0.0 2.6 3 0 0 3 3 3 0 ADP-ribosylation factor family AAA_18 PF13238.6 ETO17539.1 - 0.028 15.0 0.1 0.17 12.5 0.0 2.4 2 1 1 3 3 3 0 AAA domain AAA_16 PF13191.6 ETO17539.1 - 0.082 13.3 0.1 0.33 11.3 0.0 2.0 2 1 0 2 2 2 0 AAA ATPase domain Dynamin_N PF00350.23 ETO17539.1 - 0.92 9.5 3.7 6.4 6.8 0.0 3.2 2 2 2 4 4 4 0 Dynamin family Asp PF00026.23 ETO17540.1 - 1e-18 67.8 0.1 1.2e-18 67.6 0.1 1.1 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 ETO17540.1 - 4.4e-09 36.3 0.0 1.1e-07 31.8 0.0 2.1 1 1 0 1 1 1 1 Xylanase inhibitor C-terminal Sec23_helical PF04815.15 ETO17540.1 - 0.00059 19.6 0.1 0.11 12.4 0.0 2.2 2 0 0 2 2 2 2 Sec23/Sec24 helical domain Ras PF00071.22 ETO17542.1 - 5.3e-10 39.1 2.3 0.00016 21.3 0.7 2.9 1 1 2 3 3 3 3 Ras family Hydrolase_3 PF08282.12 ETO17543.1 - 0.027 14.2 1.5 0.061 13.1 0.9 1.9 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase IKBKB_SDD PF18397.1 ETO17543.1 - 0.1 11.9 0.0 4.5 6.5 0.0 2.2 2 0 0 2 2 2 0 IQBAL scaffold dimerization domain Glyco_transf_49 PF13896.6 ETO17544.1 - 4.7e-07 29.5 0.0 9.2e-07 28.5 0.0 1.5 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glyco_transf_49 PF13896.6 ETO17545.1 - 6.2e-30 104.7 5.8 1.9e-29 103.1 5.8 1.7 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan CDC45 PF02724.14 ETO17546.1 - 0.00031 19.2 14.8 0.00031 19.2 14.8 2.8 2 1 1 3 3 3 1 CDC45-like protein Nop53 PF07767.11 ETO17546.1 - 0.0086 15.5 11.0 0.0086 15.5 11.0 2.7 3 0 0 3 3 3 1 Nop53 (60S ribosomal biogenesis) Rrn6 PF10214.9 ETO17547.1 - 0.22 10.0 8.3 0.23 9.9 8.3 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TFIIF_alpha PF05793.12 ETO17547.1 - 0.76 8.3 32.9 1 7.9 32.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) PEX-1N PF09262.11 ETO17548.1 - 1.6e-11 44.5 0.0 3.7e-11 43.3 0.0 1.7 1 1 0 1 1 1 1 Peroxisome biogenesis factor 1, N-terminal YoaP PF14268.6 ETO17548.1 - 0.06 12.9 0.0 0.12 11.9 0.0 1.5 1 0 0 1 1 1 0 YoaP-like RNA_pol_Rpc4 PF05132.14 ETO17555.1 - 0.039 14.4 5.3 0.34 11.3 3.1 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 RNase_H2_suC PF08615.11 ETO17555.1 - 0.97 9.6 7.0 0.78 9.9 0.3 2.4 2 0 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Ins_P5_2-kin PF06090.12 ETO17555.1 - 5.3 6.4 9.7 12 5.2 9.7 1.6 1 1 0 1 1 1 0 Inositol-pentakisphosphate 2-kinase FAM150 PF15129.6 ETO17555.1 - 8.8 6.5 11.3 1.4 9.1 3.6 2.6 2 1 0 2 2 2 0 FAM150 family EF-hand_1 PF00036.32 ETO17558.1 - 1.7e-08 33.4 3.2 8.2e-06 25.0 0.4 3.0 2 0 0 2 2 2 2 EF hand EF-hand_5 PF13202.6 ETO17558.1 - 4.2e-07 29.2 2.6 2.2e-06 26.9 0.4 2.7 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO17558.1 - 6.9e-07 28.7 3.0 0.0012 18.6 0.2 3.4 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO17558.1 - 2e-06 28.1 4.6 0.00046 20.6 0.4 3.6 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO17558.1 - 7.5e-05 22.5 2.3 0.026 14.4 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair Nop14 PF04147.12 ETO17558.1 - 0.0047 15.2 47.0 0.0068 14.7 47.0 1.3 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO17558.1 - 0.011 15.2 52.8 0.016 14.7 52.8 1.2 1 0 0 1 1 1 0 SDA1 Peptidase_S64 PF08192.11 ETO17558.1 - 0.026 13.1 17.8 0.034 12.6 17.8 1.2 1 0 0 1 1 1 0 Peptidase family S64 Hid1 PF12722.7 ETO17558.1 - 0.1 10.7 25.7 0.16 10.1 25.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 ETO17558.1 - 0.33 10.3 52.8 0.52 9.6 52.8 1.3 1 0 0 1 1 1 0 BUD22 LAP1C PF05609.12 ETO17558.1 - 6.6 5.7 31.3 9.3 5.2 31.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Herpes_LMP1 PF05297.11 ETO17558.1 - 9.2 5.4 11.5 13 4.8 11.5 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) SNF2_N PF00176.23 ETO17559.1 - 1.1e-71 241.3 1.0 1.5e-71 241.0 1.0 1.1 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO17559.1 - 3.7e-11 43.3 0.0 9.3e-11 42.0 0.0 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO17559.1 - 3.4e-08 33.5 0.0 6.3e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 ETO17559.1 - 1.4e-05 24.4 0.1 2.9e-05 23.4 0.1 1.5 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 AAA_22 PF13401.6 ETO17559.1 - 8.9e-05 22.8 0.1 0.00071 19.9 0.0 2.5 2 2 0 2 2 2 1 AAA domain SWI2_SNF2 PF18766.1 ETO17559.1 - 0.00052 19.8 0.0 0.0019 17.9 0.0 1.9 1 1 0 1 1 1 1 SWI2/SNF2 ATPase TPR_1 PF00515.28 ETO17560.1 - 3.8e-07 29.7 3.0 0.0015 18.2 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17560.1 - 8e-07 28.7 3.4 0.029 14.5 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17560.1 - 9.5e-06 25.4 0.6 0.0038 17.3 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO17560.1 - 0.003 17.6 0.3 5.3 7.2 0.0 3.3 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETO17560.1 - 0.0077 16.7 3.2 0.41 11.2 0.6 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat V_ATPase_I PF01496.19 ETO17560.1 - 0.063 11.2 2.4 0.092 10.7 2.4 1.4 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TPR_12 PF13424.6 ETO17560.1 - 0.12 12.7 2.4 8.2 6.8 0.1 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17560.1 - 0.17 12.8 0.3 7.2 7.7 0.1 2.7 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17560.1 - 0.17 12.5 0.8 16 6.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17560.1 - 0.88 9.3 6.1 5.6 6.7 0.2 2.7 3 0 0 3 3 3 0 TPR repeat YMF19 PF02326.15 ETO17560.1 - 3.4 8.5 7.3 0.21 12.4 0.3 2.7 3 2 0 3 3 3 0 Plant ATP synthase F0 Rap_GAP PF02145.15 ETO17561.1 - 7e-48 162.6 0.0 8.7e-48 162.3 0.0 1.1 1 0 0 1 1 1 1 Rap/ran-GAP BUD22 PF09073.10 ETO17563.1 - 0.039 13.3 46.1 0.048 13.0 46.1 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO17563.1 - 0.92 7.6 50.0 1.2 7.3 50.0 1.0 1 0 0 1 1 1 0 Nop14-like family PNISR PF15996.5 ETO17563.1 - 2 8.6 34.9 2.8 8.2 34.9 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR TPR_12 PF13424.6 ETO17564.1 - 6.2e-108 353.2 14.0 7e-18 64.7 0.1 7.2 2 1 8 10 10 9 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17564.1 - 1.1e-60 200.0 1.1 7.3e-10 38.4 0.1 9.9 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17564.1 - 1.3e-42 141.9 30.3 5.3e-06 26.0 0.3 10.1 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17564.1 - 8.4e-34 113.1 1.8 0.00038 20.3 0.0 10.0 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17564.1 - 5.3e-30 101.1 24.9 0.00065 19.6 0.0 10.0 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17564.1 - 1.8e-23 80.7 25.8 0.00029 20.8 0.4 9.4 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17564.1 - 2.2e-11 43.3 7.8 0.69 10.4 0.0 8.0 8 0 0 8 8 7 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO17564.1 - 7e-11 42.2 9.8 3.1 7.6 0.0 8.1 8 0 0 8 8 8 2 Domain of unknown function (DUF5113) TPR_16 PF13432.6 ETO17564.1 - 4e-08 33.8 0.0 1.5 9.5 0.0 6.1 5 1 2 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17564.1 - 7.4e-07 29.5 0.0 0.28 12.1 0.0 6.5 5 2 2 7 7 6 1 Tetratricopeptide repeat MIT PF04212.18 ETO17564.1 - 3.4e-06 27.0 14.5 1.2 9.2 0.0 8.3 7 1 2 9 9 9 1 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO17564.1 - 1.3e-05 24.8 23.9 4.7 7.0 0.1 10.5 11 2 1 12 12 12 1 TPR repeat TPR_MalT PF17874.1 ETO17564.1 - 2.4e-05 23.9 0.2 0.017 14.5 0.0 3.6 2 2 1 3 3 3 1 MalT-like TPR region PPR PF01535.20 ETO17564.1 - 0.00019 21.5 8.2 5.3 7.5 0.0 6.6 8 0 0 8 8 6 1 PPR repeat DUF357 PF04010.13 ETO17564.1 - 0.00025 21.0 4.3 0.56 10.3 0.1 5.3 5 1 1 6 6 6 1 Protein of unknown function (DUF357) RPN7 PF10602.9 ETO17564.1 - 0.0008 19.2 11.3 1.4 8.6 0.4 5.5 3 2 3 6 6 6 1 26S proteasome subunit RPN7 TPR_6 PF13174.6 ETO17564.1 - 0.0013 19.2 3.4 63 4.5 0.0 6.4 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17564.1 - 0.0064 17.0 1.6 0.25 11.9 0.0 3.7 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF5475 PF17569.2 ETO17564.1 - 0.0086 16.4 0.3 3.7 7.9 0.0 3.3 2 1 0 2 2 2 1 Family of unknown function (DUF5475) Cwf_Cwc_15 PF04889.12 ETO17564.1 - 0.11 12.2 12.7 0.18 11.5 12.7 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein PPR_1 PF12854.7 ETO17564.1 - 0.15 11.8 0.8 18 5.2 0.0 3.3 4 0 0 4 4 4 0 PPR repeat NOA36 PF06524.12 ETO17564.1 - 0.39 10.0 13.5 1.1 8.5 13.5 1.8 1 0 0 1 1 1 0 NOA36 protein NRBF2_MIT PF17169.4 ETO17564.1 - 2.4 8.4 6.2 31 4.9 0.0 4.4 5 1 2 7 7 4 0 MIT domain of nuclear receptor-binding factor 2 DUF4598 PF15370.6 ETO17565.1 - 0.011 16.1 0.4 0.011 16.1 0.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4598) Exostosin PF03016.15 ETO17566.1 - 2.5e-06 26.9 0.0 4e-06 26.3 0.0 1.3 1 0 0 1 1 1 1 Exostosin family DUF573 PF04504.14 ETO17566.1 - 0.15 12.7 5.5 1.1 10.0 0.1 3.4 2 1 1 3 3 3 0 Protein of unknown function, DUF573 Bap31 PF05529.12 ETO17567.1 - 0.021 14.7 0.3 0.026 14.4 0.3 1.1 1 0 0 1 1 1 0 Bap31/Bap29 transmembrane region RicinB_lectin_2 PF14200.6 ETO17568.1 - 1e-32 112.7 0.1 1.1e-09 38.9 0.0 5.5 5 1 0 5 5 5 4 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ETO17568.1 - 0.062 13.6 3.8 4.9 7.4 0.5 4.3 4 0 0 4 4 4 0 Ricin-type beta-trefoil lectin domain ING PF12998.7 ETO17570.1 - 0.21 12.2 3.8 13 6.5 0.1 3.2 2 1 1 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding DEDD_Tnp_IS110 PF01548.17 ETO17570.1 - 0.23 11.3 0.1 0.23 11.3 0.1 2.2 3 0 0 3 3 3 0 Transposase DUF2654 PF10849.8 ETO17570.1 - 1.4 9.2 8.9 8.5 6.7 0.1 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2654) BLOC1_2 PF10046.9 ETO17570.1 - 8.3 6.8 14.8 0.49 10.7 0.2 4.2 4 1 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Imm5 PF14423.6 ETO17570.1 - 8.5 6.6 13.7 0.43 10.8 2.1 3.1 2 2 1 3 3 3 0 Immunity protein Imm5 Topoisom_I_N PF02919.15 ETO17572.1 - 0.15 11.5 0.0 0.26 10.8 0.0 1.3 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment Pkinase PF00069.25 ETO17574.1 - 5.7e-25 88.2 0.0 8.9e-15 54.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17574.1 - 1.3e-18 67.3 0.1 4.6e-18 65.4 0.1 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ETO17574.1 - 0.064 12.9 0.1 2.4 7.7 0.1 2.2 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Lentiviral_Tat PF02998.14 ETO17574.1 - 0.082 13.0 0.1 0.14 12.2 0.1 1.3 1 0 0 1 1 1 0 Lentiviral Tat protein CEP44 PF15007.6 ETO17575.1 - 3.3e-47 159.8 1.0 6.3e-47 158.9 1.0 1.5 1 0 0 1 1 1 1 Centrosomal spindle body, CEP44 DUF4484 PF14831.6 ETO17576.1 - 0.11 12.6 4.2 0.068 13.2 0.6 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) WD40 PF00400.32 ETO17577.1 - 8e-16 58.2 13.5 1e-06 29.4 0.2 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO17577.1 - 4.5e-08 32.2 0.3 0.00027 19.7 0.1 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO17577.1 - 6.6e-06 26.3 0.0 0.066 13.5 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO17577.1 - 0.0036 16.7 1.4 0.047 13.0 1.2 2.0 2 0 0 2 2 2 1 WD40-like domain WD40 PF00400.32 ETO17578.1 - 6.4e-65 213.5 25.1 4e-10 40.1 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17578.1 - 2e-20 72.9 2.0 0.0032 17.7 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17578.1 - 7.8e-14 51.4 0.5 0.0048 15.9 0.0 5.5 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO17578.1 - 1.8e-09 37.7 1.4 0.00018 21.5 0.2 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO17578.1 - 4.2e-08 32.3 9.6 0.096 11.3 0.1 4.7 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO17578.1 - 1.5e-07 31.1 0.2 0.35 10.1 0.0 3.8 2 2 2 4 4 4 3 WD40-like domain DUF5570 PF17731.1 ETO17578.1 - 3.2e-05 24.0 5.2 0.42 10.7 0.3 4.3 2 2 2 4 4 4 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO17578.1 - 6.2e-05 21.7 2.2 0.16 10.5 0.1 3.0 1 1 1 3 3 3 3 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO17578.1 - 0.00039 19.4 3.1 2.5 6.9 0.0 4.9 3 2 3 6 6 6 1 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO17578.1 - 0.00071 19.4 2.5 4.5 7.3 0.0 4.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO17578.1 - 0.016 14.8 0.7 0.037 13.6 0.1 1.9 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region HARP PF07443.13 ETO17578.1 - 0.091 12.4 0.5 8.9 6.0 0.1 3.9 4 0 0 4 4 4 0 HepA-related protein (HARP) Proteasome_A_N PF10584.9 ETO17578.1 - 0.42 10.3 4.8 20 5.0 0.0 4.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature AAA_12 PF13087.6 ETO17579.1 - 1.7e-24 86.6 0.0 5.2e-24 85.0 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETO17579.1 - 3.5e-08 33.6 5.8 8.3e-05 22.5 0.0 2.9 3 0 0 3 3 3 2 AAA domain FSA_C PF10479.9 ETO17580.1 - 0.042 12.0 5.3 0.048 11.8 5.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TAF4 PF05236.14 ETO17580.1 - 0.051 13.3 4.1 0.057 13.2 4.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF3439 PF11921.8 ETO17580.1 - 0.074 13.0 9.8 0.11 12.5 9.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4718 PF15842.5 ETO17580.1 - 0.092 12.5 5.4 0.13 12.1 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Mucin PF01456.17 ETO17580.1 - 0.12 12.4 21.9 0.16 12.0 21.9 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF819 PF05684.12 ETO17580.1 - 0.13 11.3 1.0 0.16 11.0 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF819) BRF1 PF07741.13 ETO17580.1 - 0.13 12.6 3.7 0.2 12.0 3.7 1.3 1 0 0 1 1 1 0 Brf1-like TBP-binding domain BAF1_ABF1 PF04684.13 ETO17580.1 - 0.13 11.3 3.7 0.15 11.1 3.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor MGC-24 PF05283.11 ETO17580.1 - 0.77 10.2 8.8 1.1 9.7 8.8 1.2 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin BSP_II PF05432.11 ETO17580.1 - 0.96 9.1 10.2 1.2 8.8 10.2 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Dicty_REP PF05086.12 ETO17580.1 - 1.4 6.8 5.7 1.7 6.5 5.7 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Hid1 PF12722.7 ETO17580.1 - 5.1 5.1 7.4 5.9 4.9 7.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Med3 PF11593.8 ETO17580.1 - 9.8 5.2 12.5 14 4.7 12.5 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DNA_pol_A PF00476.20 ETO17581.1 - 6.2e-36 124.2 1.8 2.5e-20 72.9 0.6 2.1 2 0 0 2 2 2 2 DNA polymerase family A SDA1 PF05285.12 ETO17581.1 - 0.03 13.8 1.8 0.038 13.4 1.8 1.2 1 0 0 1 1 1 0 SDA1 FidL_like PF15941.5 ETO17581.1 - 0.14 12.6 2.4 0.4 11.2 2.4 1.8 1 0 0 1 1 1 0 FidL-like putative membrane protein Spt5_N PF11942.8 ETO17581.1 - 0.15 13.0 11.0 0.3 12.1 8.8 2.1 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Nop14 PF04147.12 ETO17581.1 - 0.31 9.2 4.5 0.41 8.8 4.5 1.1 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ETO17581.1 - 0.36 10.9 3.5 0.6 10.2 3.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 ETO17581.1 - 0.7 9.2 9.8 1.1 8.6 9.8 1.3 1 0 0 1 1 1 0 NOA36 protein DUF3295 PF11702.8 ETO17581.1 - 1 8.7 5.6 1.3 8.3 5.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) DNA_pol_phi PF04931.13 ETO17581.1 - 2.4 6.2 11.3 3.4 5.7 11.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Acyltransferase PF01553.21 ETO17582.1 - 2.6e-10 40.0 0.1 4.1e-10 39.4 0.1 1.3 1 0 0 1 1 1 1 Acyltransferase DUF5436 PF17504.2 ETO17582.1 - 0.12 12.7 0.1 0.3 11.4 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5436) LAP1C PF05609.12 ETO17583.1 - 1.3 8.1 32.7 0.054 12.6 23.7 2.0 1 1 1 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) MFS_1 PF07690.16 ETO17584.1 - 0.00016 20.8 8.6 0.00034 19.6 8.9 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF2207 PF09972.9 ETO17584.1 - 0.22 10.2 0.4 0.28 9.9 0.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AP3D1 PF06375.11 ETO17584.1 - 3.9 7.7 5.7 4.8 7.4 5.7 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Sugar_tr PF00083.24 ETO17584.1 - 7.7 5.2 11.2 1.1 8.0 4.2 2.0 1 1 1 2 2 2 0 Sugar (and other) transporter Pox_Ag35 PF03286.14 ETO17587.1 - 0.11 12.2 1.5 0.14 12.0 1.5 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO17587.1 - 0.32 10.3 7.8 0.38 10.0 7.8 1.1 1 0 0 1 1 1 0 NOA36 protein MRNIP PF15749.5 ETO17587.1 - 0.85 10.4 4.1 1.1 10.0 4.1 1.2 1 0 0 1 1 1 0 MRN-interacting protein DUF2457 PF10446.9 ETO17587.1 - 3.7 6.6 8.7 4.2 6.4 8.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 ETO17587.1 - 6.1 7.3 10.0 9.5 6.7 10.0 1.2 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sec16 PF12932.7 ETO17588.1 - 0.1 13.2 1.5 0.26 11.9 0.5 1.8 1 1 1 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region AXH PF08517.12 ETO17588.1 - 0.16 12.5 1.7 0.33 11.5 0.3 1.9 2 0 0 2 2 2 0 Ataxin-1 and HBP1 module (AXH) EspB PF05802.11 ETO17588.1 - 0.37 10.8 3.1 0.29 11.1 1.7 1.5 1 1 0 1 1 1 0 Enterobacterial EspB protein CSG2 PF16965.5 ETO17588.1 - 2.1 7.2 4.6 2.7 6.9 4.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Prenyltrans PF00432.21 ETO17589.1 - 1.2e-15 56.9 3.6 1.4e-06 27.9 0.0 4.1 4 0 0 4 4 4 3 Prenyltransferase and squalene oxidase repeat EFG_II PF14492.6 ETO17589.1 - 0.15 12.1 0.0 0.32 11.1 0.0 1.5 1 1 0 1 1 1 0 Elongation Factor G, domain II Prenyltrans PF00432.21 ETO17590.1 - 3.2e-11 42.8 1.3 7.7e-05 22.4 0.3 2.2 2 0 0 2 2 2 2 Prenyltransferase and squalene oxidase repeat DTC PF18102.1 ETO17591.1 - 1e-54 184.2 0.1 1.9e-54 183.4 0.1 1.5 1 0 0 1 1 1 1 Deltex C-terminal domain zf-rbx1 PF12678.7 ETO17591.1 - 2.6e-07 30.8 4.1 5.4e-07 29.8 1.1 2.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETO17591.1 - 4.3e-05 23.7 0.6 4.3e-05 23.7 0.6 3.1 3 0 0 3 3 3 2 Ring finger domain zf-ANAPC11 PF12861.7 ETO17591.1 - 0.0012 18.8 0.6 0.0012 18.8 0.6 2.1 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ETO17591.1 - 0.0031 17.3 0.7 0.0031 17.3 0.7 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO17591.1 - 0.013 15.3 2.8 1.2 9.0 0.2 2.9 3 0 0 3 3 3 0 RING-like zinc finger zf-C3HC4 PF00097.25 ETO17591.1 - 0.016 15.1 0.5 0.016 15.1 0.5 3.3 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO17591.1 - 0.032 14.2 0.3 0.032 14.2 0.3 2.9 2 1 0 2 2 2 0 zinc-RING finger domain WWE PF02825.20 ETO17592.1 - 2e-07 31.5 2.0 2e-07 31.5 2.0 2.5 2 0 0 2 2 2 1 WWE domain DUF3413 PF11893.8 ETO17593.1 - 0.0019 17.4 2.8 0.0032 16.7 2.8 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3413) DUF5020 PF16412.5 ETO17594.1 - 0.0018 18.2 0.2 0.003 17.4 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5020) TLD PF07534.16 ETO17595.1 - 1.6e-15 57.6 0.1 2.3e-15 57.0 0.1 1.3 1 0 0 1 1 1 1 TLD Mito_carr PF00153.27 ETO17596.1 - 1.7e-15 56.7 5.2 9.8e-06 25.4 0.3 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein Sulfatase PF00884.23 ETO17599.1 - 8.1e-13 48.4 0.0 1e-12 48.1 0.0 1.0 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ETO17599.1 - 0.0038 16.9 0.0 0.0038 16.9 0.0 1.2 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase FlxA PF14282.6 ETO17600.1 - 0.00013 21.9 15.3 0.00013 21.9 15.3 2.9 2 1 1 3 3 3 1 FlxA-like protein HALZ PF02183.18 ETO17600.1 - 0.0048 17.1 0.1 0.0048 17.1 0.1 3.2 3 0 0 3 3 3 1 Homeobox associated leucine zipper KLRAQ PF10205.9 ETO17600.1 - 0.013 15.7 9.9 0.013 15.7 9.9 3.1 2 1 1 3 3 3 0 Predicted coiled-coil domain-containing protein DUF1664 PF07889.12 ETO17600.1 - 0.029 14.4 1.7 0.029 14.4 1.7 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF2240 PF09999.9 ETO17600.1 - 0.075 12.7 0.5 0.17 11.6 0.4 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2240) DUF4250 PF14056.6 ETO17600.1 - 0.22 11.5 2.4 0.47 10.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4250) DUF3450 PF11932.8 ETO17600.1 - 2.5 7.3 23.1 1.8 7.8 13.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Lipoprotein_2 PF00921.17 ETO17600.1 - 6.9 6.1 9.3 1.1e+02 2.2 8.0 2.4 1 1 0 1 1 1 0 Borrelia lipoprotein BNIP2 PF12496.8 ETO17600.1 - 7.8 6.9 7.9 2.3 8.6 4.0 2.1 1 1 1 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 Guanylate_cyc PF00211.20 ETO17601.1 - 4.5e-13 49.2 0.0 6.3e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain VPDSG-CTERM PF18205.1 ETO17601.1 - 0.034 13.9 1.3 0.053 13.3 0.2 2.0 2 0 0 2 2 2 0 VPDSG-CTERM motif WYL_2 PF10902.8 ETO17601.1 - 0.13 12.6 0.0 0.22 11.9 0.0 1.4 1 0 0 1 1 1 0 WYL_2, Sm-like SH3 beta-barrel fold Spt20 PF12090.8 ETO17602.1 - 0.0051 16.4 19.3 0.0059 16.2 19.3 1.2 1 0 0 1 1 1 1 Spt20 family TFIIA PF03153.13 ETO17602.1 - 0.18 11.8 17.9 0.19 11.7 17.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 ETO17602.1 - 0.18 10.6 9.5 0.18 10.6 9.5 1.1 1 0 0 1 1 1 0 Androgen receptor Roughex PF06020.11 ETO17602.1 - 0.4 9.7 4.9 0.4 9.7 4.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein Phostensin PF13914.6 ETO17602.1 - 0.51 11.0 10.5 0.21 12.2 8.2 1.5 1 1 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region DUF4647 PF15504.6 ETO17602.1 - 1.5 7.8 17.3 1.8 7.6 17.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4647) Sec62 PF03839.16 ETO17602.1 - 2.9 7.4 10.4 3.3 7.2 10.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Neur_chan_memb PF02932.16 ETO17602.1 - 3.7 7.5 9.0 4.1 7.4 9.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 ETO17602.1 - 5.6 6.7 13.0 6.2 6.6 13.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 p450 PF00067.22 ETO17603.1 - 0.0033 16.2 1.5 0.004 15.9 1.5 1.1 1 0 0 1 1 1 1 Cytochrome P450 Menin PF05053.13 ETO17603.1 - 0.29 9.4 16.6 0.44 8.9 16.6 1.2 1 0 0 1 1 1 0 Menin ETRAMP PF09716.10 ETO17603.1 - 0.52 10.4 0.0 0.52 10.4 0.0 3.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Tim54 PF11711.8 ETO17603.1 - 2.9 6.6 8.8 4.3 6.0 8.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 FAM76 PF16046.5 ETO17603.1 - 3.7 6.8 14.5 7.7 5.8 14.5 1.4 1 0 0 1 1 1 0 FAM76 protein PNISR PF15996.5 ETO17603.1 - 7.8 6.7 12.5 1.6 9.0 9.2 1.6 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR FliS PF02561.14 ETO17605.1 - 6.5e-28 97.3 3.5 1.3e-27 96.4 1.0 2.5 3 0 0 3 3 3 1 Flagellar protein FliS FliD_C PF07195.12 ETO17605.1 - 2.8e-24 85.9 9.1 4.4e-24 85.2 9.1 1.4 1 1 0 1 1 1 1 Flagellar hook-associated protein 2 C-terminus DUF3834 PF12916.7 ETO17605.1 - 0.014 14.6 0.3 5.2 6.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3834) HP0268 PF18618.1 ETO17605.1 - 0.078 13.4 0.2 0.71 10.3 0.1 2.3 2 0 0 2 2 2 0 HP0268 CLZ PF16526.5 ETO17605.1 - 0.1 13.0 0.6 1.8 8.9 0.1 2.5 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fes1 PF08609.10 ETO17605.1 - 0.24 12.3 2.5 0.28 12.1 0.2 2.2 2 1 0 2 2 2 0 Nucleotide exchange factor Fes1 FNIP_N PF14636.6 ETO17607.1 - 0.00098 20.1 9.6 0.00098 20.1 9.6 1.7 1 1 1 2 2 2 1 Folliculin-interacting protein N-terminus Androgen_recep PF02166.16 ETO17607.1 - 0.0049 15.8 5.2 0.0066 15.4 5.2 1.1 1 0 0 1 1 1 1 Androgen receptor STAG PF08514.11 ETO17607.1 - 0.019 14.9 1.5 0.052 13.5 1.5 1.8 1 0 0 1 1 1 0 STAG domain Chorein_N PF12624.7 ETO17607.1 - 0.021 15.0 0.4 0.047 13.8 0.4 1.6 1 0 0 1 1 1 0 N-terminal region of Chorein or VPS13 Spt20 PF12090.8 ETO17607.1 - 0.046 13.3 14.2 0.12 12.0 14.2 1.7 1 0 0 1 1 1 0 Spt20 family RPA43_OB PF17875.1 ETO17607.1 - 0.11 13.1 0.1 0.11 13.1 0.1 2.5 2 1 0 2 2 2 0 RPA43 OB domain in RNA Pol I DDE_Tnp_1_2 PF13586.6 ETO17607.1 - 0.12 12.8 0.8 0.34 11.3 0.8 1.8 1 0 0 1 1 1 0 Transposase DDE domain TFIIA PF03153.13 ETO17607.1 - 0.25 11.3 16.3 0.19 11.7 15.2 1.3 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2254 PF10011.9 ETO17607.1 - 0.26 10.1 1.2 0.34 9.7 1.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) DUF5349 PF17298.2 ETO17607.1 - 2.4 7.8 19.3 0.11 12.2 10.5 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5349) Pkinase PF00069.25 ETO17610.1 - 7.1e-22 78.0 0.1 6.3e-20 71.6 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17610.1 - 3e-05 23.5 0.0 5.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ETO17610.1 - 0.027 14.1 0.4 0.21 11.2 0.1 2.1 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ETO17610.1 - 0.03 13.6 0.4 0.98 8.7 0.1 2.1 2 0 0 2 2 2 0 Kinase-like Pkinase_fungal PF17667.1 ETO17610.1 - 0.033 13.0 0.6 0.1 11.3 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Kdo PF06293.14 ETO17610.1 - 0.048 13.0 0.2 0.079 12.3 0.2 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO17610.1 - 0.1 12.5 0.0 1.6 8.6 0.0 2.2 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase PF00069.25 ETO17611.1 - 1.5e-71 240.9 0.9 2.2e-71 240.3 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17611.1 - 3.7e-41 141.1 0.2 5.3e-41 140.6 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ETO17611.1 - 1.1e-06 29.1 0.0 3.1e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 PH domain Kinase-like PF14531.6 ETO17611.1 - 8.5e-05 22.0 0.0 0.00022 20.6 0.0 1.7 1 1 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO17611.1 - 0.00021 20.7 0.2 0.00037 19.9 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO17611.1 - 0.0098 14.7 0.0 0.0098 14.7 0.0 2.3 3 0 0 3 3 3 1 Fungal protein kinase RAMP4 PF06624.12 ETO17611.1 - 0.11 12.6 0.1 2.2 8.4 0.0 2.5 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 SPC25 PF06703.11 ETO17612.1 - 0.042 13.6 0.1 0.042 13.6 0.1 2.7 3 0 0 3 3 3 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF3687 PF12459.8 ETO17612.1 - 0.06 12.9 2.4 0.21 11.2 2.4 2.0 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein Sfi1_C PF10638.9 ETO17612.1 - 0.067 14.0 1.2 0.12 13.2 1.2 1.3 1 0 0 1 1 1 0 Spindle body associated protein C-terminus DUF4852 PF16144.5 ETO17613.1 - 0.0023 18.0 0.4 0.0044 17.1 0.4 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4852) DUF515 PF04415.12 ETO17613.1 - 0.0029 16.1 1.2 0.0034 15.8 1.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF515) GAF PF01590.26 ETO17614.1 - 4.7e-09 37.0 0.0 8.9e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 GAF domain GAF_2 PF13185.6 ETO17614.1 - 1.3e-05 25.5 0.0 3.2e-05 24.2 0.0 1.6 1 1 0 1 1 1 1 GAF domain Ricin_B_lectin PF00652.22 ETO17614.1 - 0.063 13.5 0.2 0.15 12.3 0.2 1.6 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain CDC27 PF09507.10 ETO17615.1 - 0.0012 18.4 20.5 0.0014 18.1 20.5 1.2 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ETO17615.1 - 0.021 13.0 20.2 0.025 12.8 20.2 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 ETO17615.1 - 0.032 12.9 34.8 0.055 12.0 34.8 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GREB1 PF15782.5 ETO17615.1 - 0.54 7.3 7.1 0.61 7.1 7.1 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF936 PF06075.12 ETO17615.1 - 0.75 8.6 19.3 0.95 8.3 19.3 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Nop53 PF07767.11 ETO17615.1 - 0.78 9.1 31.0 1.3 8.3 31.0 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Mucin PF01456.17 ETO17615.1 - 1.5 8.8 4.4 3.1 7.8 4.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein CDC45 PF02724.14 ETO17615.1 - 3.7 5.7 23.3 6.7 4.9 23.3 1.4 1 0 0 1 1 1 0 CDC45-like protein DUF3377 PF11857.8 ETO17616.1 - 3.1 7.8 6.3 1.5 8.8 0.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3377) Gal-3-0_sulfotr PF06990.11 ETO17617.1 - 0.029 13.2 0.1 0.042 12.7 0.1 1.2 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase IBN_N PF03810.19 ETO17618.1 - 0.00014 21.7 0.2 0.0058 16.5 0.0 2.3 2 0 0 2 2 2 2 Importin-beta N-terminal domain RE_HaeIII PF09556.10 ETO17618.1 - 0.045 12.8 1.5 0.1 11.7 1.4 1.5 1 1 0 1 1 1 0 HaeIII restriction endonuclease PH_12 PF16457.5 ETO17619.1 - 1.5e-08 35.3 2.5 4.4e-08 33.7 1.1 2.2 2 0 0 2 2 2 1 Pleckstrin homology domain PH_14 PF17787.1 ETO17619.1 - 0.0011 18.8 0.3 0.0035 17.2 0.3 1.8 1 1 0 1 1 1 1 PH domain PH PF00169.29 ETO17619.1 - 0.0075 16.8 0.4 0.012 16.1 0.4 1.4 1 0 0 1 1 1 1 PH domain Mcp5_PH PF12814.7 ETO17619.1 - 0.11 12.6 1.1 0.16 12.1 0.4 1.7 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology GGDEF_2 PF17853.1 ETO17619.1 - 0.16 12.2 0.0 0.81 10.0 0.0 2.1 3 0 0 3 3 3 0 GGDEF-like domain Asp PF00026.23 ETO17620.1 - 1e-38 133.5 2.4 2.6e-38 132.2 2.4 1.6 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO17620.1 - 7.3e-07 29.6 3.2 0.00017 21.9 0.4 2.5 1 1 1 2 2 2 2 Xylanase inhibitor N-terminal CRM1_C PF08767.11 ETO17621.1 - 9.2e-08 31.6 0.1 1.3e-07 31.1 0.1 1.2 1 0 0 1 1 1 1 CRM1 C terminal FliS PF02561.14 ETO17621.1 - 0.083 13.2 0.0 0.19 12.0 0.0 1.7 1 0 0 1 1 1 0 Flagellar protein FliS Peptidase_M16_C PF05193.21 ETO17622.1 - 2.2e-10 40.8 0.1 3.2e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 Peptidase M16 inactive domain Mo25 PF08569.11 ETO17623.1 - 7.6e-69 232.6 12.0 8.8e-69 232.4 12.0 1.1 1 0 0 1 1 1 1 Mo25-like HMGL-like PF00682.19 ETO17624.1 - 4.2e-15 56.0 0.0 6.7e-15 55.4 0.0 1.3 1 0 0 1 1 1 1 HMGL-like RuvC_1 PF18516.1 ETO17624.1 - 0.031 13.5 0.0 0.043 13.0 0.0 1.2 1 0 0 1 1 1 0 RuvC nuclease domain OAD_gamma PF04277.13 ETO17625.1 - 2.9 8.5 5.6 0.49 11.0 0.6 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain MMPL PF03176.15 ETO17627.1 - 0.058 12.3 0.4 0.087 11.7 0.4 1.1 1 0 0 1 1 1 0 MMPL family EMP24_GP25L PF01105.24 ETO17627.1 - 0.25 11.3 5.2 1.4 8.8 0.3 3.0 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD USP7_ICP0_bdg PF12436.8 ETO17628.1 - 9.9e-22 77.4 0.1 1.1e-21 77.2 0.1 1.1 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 FbpA PF05833.11 ETO17629.1 - 1.3e-09 37.4 0.5 2.1e-09 36.7 0.5 1.2 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Vps16_C PF04840.12 ETO17630.1 - 4.1e-07 29.3 3.4 5.4e-06 25.7 0.7 2.1 2 0 0 2 2 2 2 Vps16, C-terminal region WD40 PF00400.32 ETO17631.1 - 8.8e-65 213.1 9.8 1.3e-10 41.7 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17631.1 - 2.4e-26 91.9 1.0 0.0002 21.6 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17631.1 - 8.9e-16 57.7 0.1 0.0083 15.1 0.0 6.6 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO17631.1 - 6.6e-15 55.5 0.0 0.0003 20.8 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO17631.1 - 2.4e-11 43.5 0.1 0.00017 21.1 0.0 3.8 3 1 1 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO17631.1 - 3.3e-09 36.4 3.1 1.1 9.3 0.3 6.5 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO17631.1 - 3.7e-08 32.5 2.1 2.3 6.8 0.0 5.5 1 1 4 6 6 6 4 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO17631.1 - 1.9e-06 26.9 0.0 0.036 12.8 0.0 4.2 2 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO17631.1 - 1.9e-06 28.0 0.9 0.85 9.7 0.0 5.0 1 1 5 6 6 6 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO17631.1 - 8.4e-06 24.6 0.2 0.084 11.4 0.0 2.9 1 1 1 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO17631.1 - 8.4e-06 24.9 3.9 0.45 9.4 0.0 5.0 1 1 4 6 6 6 1 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO17631.1 - 1e-05 25.0 0.4 0.57 9.5 0.0 4.6 1 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO17631.1 - 3.6e-05 23.4 0.1 1.9 8.0 0.0 2.9 2 1 0 2 2 2 1 PQQ-like domain SBD PF17882.1 ETO17631.1 - 0.0016 18.2 0.3 3.2 7.6 0.0 3.9 2 1 1 4 4 4 1 OAA-family lectin sugar binding domain DUF1513 PF07433.11 ETO17631.1 - 0.0065 15.6 0.2 13 4.7 0.0 3.6 1 1 1 4 4 4 0 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.11 ETO17631.1 - 0.0066 15.2 4.6 5.1 5.7 2.7 4.7 1 1 1 2 2 2 1 Nup133 N terminal like DUF1815 PF08844.10 ETO17631.1 - 0.013 15.5 0.0 0.43 10.6 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF1815) Utp8 PF10395.9 ETO17631.1 - 0.026 13.0 0.0 5.5 5.4 0.0 3.2 1 1 2 4 4 4 0 Utp8 family VID27 PF08553.10 ETO17631.1 - 0.035 13.2 0.1 11 5.0 0.0 2.8 2 1 0 3 3 3 0 VID27 C-terminal WD40-like domain Proteasome_A_N PF10584.9 ETO17631.1 - 0.036 13.7 6.7 22 4.8 0.1 4.7 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature nos_propeller PF18764.1 ETO17631.1 - 0.11 12.4 0.0 45 4.0 0.0 3.6 3 1 0 3 3 3 0 Nitrous oxide reductase propeller repeat Hint PF01079.20 ETO17631.1 - 0.14 11.6 0.1 3.6 7.0 0.0 2.9 2 1 1 3 3 3 0 Hint module NHL PF01436.21 ETO17631.1 - 0.46 10.6 4.2 1.6 8.9 0.1 3.7 4 0 0 4 4 4 0 NHL repeat DUF2209 PF09974.9 ETO17633.1 - 0.082 13.2 0.0 0.12 12.7 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2209) Sulphotransf PF09037.10 ETO17634.1 - 0.01 15.4 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 0 Stf0 sulphotransferase Sulfotransfer_3 PF13469.6 ETO17634.1 - 0.032 14.6 0.0 0.14 12.5 0.0 1.8 2 0 0 2 2 2 0 Sulfotransferase family Roc PF08477.13 ETO17635.1 - 0.026 14.7 0.0 0.036 14.3 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO17635.1 - 0.13 11.9 0.1 0.16 11.5 0.1 1.2 1 0 0 1 1 1 0 Ras family Ribosomal_S8e PF01201.22 ETO17635.1 - 0.17 12.1 0.0 0.19 11.9 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein S8e Pkinase PF00069.25 ETO17637.1 - 2.9e-44 151.4 2.9 3.7e-43 147.8 2.9 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17637.1 - 2e-17 63.3 1.5 2.2e-13 50.1 0.0 3.0 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO17637.1 - 0.00044 19.2 0.1 0.0011 17.8 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO17637.1 - 0.0021 17.5 0.4 0.14 11.5 0.1 2.8 2 1 1 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO17637.1 - 0.16 11.8 0.1 0.38 10.6 0.1 1.6 1 1 0 1 1 1 0 Phosphotransferase enzyme family LisH_2 PF16045.5 ETO17638.1 - 0.037 13.1 0.0 0.095 11.7 0.0 1.7 1 0 0 1 1 1 0 LisH DUF3262 PF11660.8 ETO17638.1 - 0.076 13.4 0.9 0.076 13.4 0.9 2.9 3 1 1 4 4 4 0 Protein of unknown function (DUF3262) Aldedh PF00171.22 ETO17640.1 - 3.8e-56 190.5 0.0 5.6e-56 190.0 0.0 1.2 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CLASP_N PF12348.8 ETO17641.1 - 0.051 13.1 0.0 0.069 12.7 0.0 1.1 1 0 0 1 1 1 0 CLASP N terminal DMAP1 PF05499.12 ETO17643.1 - 0.42 10.5 11.7 0.023 14.6 3.1 2.3 3 0 0 3 3 3 0 DNA methyltransferase 1-associated protein 1 (DMAP1) MRNIP PF15749.5 ETO17643.1 - 0.51 11.1 8.7 0.18 12.6 6.1 1.6 2 0 0 2 2 2 0 MRN-interacting protein MyTH4 PF00784.17 ETO17644.1 - 1.7e-10 41.4 0.0 3e-10 40.6 0.0 1.4 1 0 0 1 1 1 1 MyTH4 domain RA PF00788.23 ETO17644.1 - 0.00025 21.6 0.0 0.00039 21.0 0.0 1.4 1 0 0 1 1 1 1 Ras association (RalGDS/AF-6) domain FERM_N PF09379.10 ETO17644.1 - 0.00055 19.8 0.0 0.00083 19.3 0.0 1.3 1 0 0 1 1 1 1 FERM N-terminal domain FERM_M PF00373.18 ETO17645.1 - 2.1e-14 54.0 0.4 3.8e-14 53.1 0.4 1.5 1 0 0 1 1 1 1 FERM central domain Smg8_Smg9 PF10220.9 ETO17646.1 - 0.036 12.4 3.9 0.049 11.9 3.9 1.0 1 0 0 1 1 1 0 Smg8_Smg9 RP-C_C PF11800.8 ETO17646.1 - 2.2 8.3 5.0 3 7.9 5.0 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Menin PF05053.13 ETO17646.1 - 2.2 6.5 7.1 2.9 6.1 7.1 1.1 1 0 0 1 1 1 0 Menin PI3K_C2 PF00792.24 ETO17649.1 - 0.041 13.8 0.3 0.055 13.4 0.0 1.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase C2 Acatn PF13000.7 ETO17650.1 - 0.032 12.7 0.5 0.04 12.4 0.5 1.1 1 0 0 1 1 1 0 Acetyl-coenzyme A transporter 1 Rsc14 PF08586.10 ETO17650.1 - 0.079 13.8 2.5 0.085 13.7 0.9 1.8 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit XK-related PF09815.9 ETO17651.1 - 1.6e-05 24.2 9.5 4.5e-05 22.7 9.5 1.7 1 1 0 1 1 1 1 XK-related protein DUF1287 PF06940.11 ETO17653.1 - 0.078 12.6 0.3 0.12 12.1 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) AARP2CN PF08142.12 ETO17653.1 - 0.11 12.6 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 AARP2CN (NUC121) domain HemY_N PF07219.13 ETO17656.1 - 0.095 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 HemY protein N-terminus FAM163 PF15069.6 ETO17656.1 - 1.3 9.5 9.6 15 6.0 9.6 2.4 1 1 0 1 1 1 0 FAM163 family GlcNAc PF11397.8 ETO17657.1 - 7.2e-24 84.9 0.0 1.2e-23 84.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) XRN1_D2_D3 PF18334.1 ETO17659.1 - 0.27 11.5 2.3 11 6.3 0.3 2.4 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain Orf78 PF06024.12 ETO17660.1 - 0.069 13.5 4.3 1.1 9.6 0.1 3.1 3 1 0 3 3 3 0 Orf78 (ac78) Mid2 PF04478.12 ETO17660.1 - 0.13 12.1 0.2 0.62 9.9 0.0 2.0 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor DUF2909 PF11137.8 ETO17660.1 - 7.5 6.6 9.2 17 5.4 1.9 3.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2909) RRM_1 PF00076.22 ETO17661.1 - 5.1e-09 35.8 0.0 0.015 15.1 0.0 3.7 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Corona_nucleoca PF00937.18 ETO17662.1 - 0.0027 16.8 7.4 0.0027 16.8 7.4 2.2 2 0 0 2 2 2 1 Coronavirus nucleocapsid protein Transformer PF06495.11 ETO17662.1 - 0.058 13.5 12.6 0.15 12.1 12.6 1.7 1 0 0 1 1 1 0 Fruit fly transformer protein PGM_PMM_IV PF00408.20 ETO17663.1 - 1.4e-08 34.8 0.0 2e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, C-terminal domain DDA1 PF10172.9 ETO17663.1 - 0.079 13.2 0.0 0.22 11.8 0.0 1.8 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase zf-met2 PF12907.7 ETO17663.1 - 0.12 12.5 0.1 0.28 11.4 0.1 1.6 1 0 0 1 1 1 0 Zinc-binding Vps54_N PF10475.9 ETO17664.1 - 3.5e-18 65.9 14.9 8.5e-17 61.4 14.9 2.1 1 1 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Ran_BP1 PF00638.18 ETO17665.1 - 0.005 17.1 0.7 0.005 17.1 0.7 2.0 2 0 0 2 2 2 1 RanBP1 domain KH_5 PF13184.6 ETO17665.1 - 0.078 13.1 0.5 0.16 12.0 0.5 1.5 1 0 0 1 1 1 0 NusA-like KH domain dsRBD2 PF17842.1 ETO17665.1 - 3 8.1 0.0 3 8.1 0.0 2.8 2 1 1 3 3 3 0 Double-stranded RNA binding domain 2 Spb1_C PF07780.12 ETO17667.1 - 9.2e-47 159.4 15.5 1.2e-46 159.0 15.5 1.1 1 0 0 1 1 1 1 Spb1 C-terminal domain Dicty_REP PF05086.12 ETO17668.1 - 0.23 9.4 16.3 0.017 13.2 2.0 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein GREB1 PF15782.5 ETO17668.1 - 0.29 8.2 7.4 0.37 7.9 7.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4718 PF15842.5 ETO17668.1 - 9 6.1 12.4 4.1 7.1 0.6 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4718) Dscam_C PF12355.8 ETO17669.1 - 0.072 14.1 0.8 0.13 13.2 0.8 1.4 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal Myc_N PF01056.18 ETO17671.1 - 0.25 11.2 13.5 0.31 10.9 13.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region TRAP_alpha PF03896.16 ETO17671.1 - 0.51 9.5 6.2 0.71 9.0 6.2 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4746 PF15928.5 ETO17671.1 - 3.3 7.1 15.4 3.8 6.9 15.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NARP1 PF12569.8 ETO17671.1 - 5.4 5.8 19.2 6.9 5.5 19.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 PBP_sp32 PF07222.12 ETO17671.1 - 8.6 5.7 14.6 13 5.1 14.6 1.4 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Paf1 PF03985.13 ETO17671.1 - 8.9 5.2 23.9 11 4.9 23.9 1.1 1 0 0 1 1 1 0 Paf1 Pkinase PF00069.25 ETO17672.1 - 3.2e-32 111.9 1.0 4.2e-32 111.6 1.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17672.1 - 6.4e-17 61.7 0.9 6.9e-17 61.6 0.9 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FWWh PF14922.6 ETO17673.1 - 1.2e-10 41.5 3.8 1.2e-10 41.5 3.8 1.5 1 1 0 1 1 1 1 Protein of unknown function TCL1_MTCP1 PF01840.17 ETO17673.1 - 0.87 9.3 4.5 0.35 10.5 2.2 1.6 1 1 1 2 2 2 0 TCL1/MTCP1 family DUF2417 PF10329.9 ETO17674.1 - 0.063 12.7 0.1 0.063 12.7 0.1 2.0 2 1 0 2 2 2 0 Region of unknown function (DUF2417) AI-2E_transport PF01594.16 ETO17674.1 - 0.23 10.5 3.0 0.57 9.3 0.0 2.0 2 0 0 2 2 2 0 AI-2E family transporter Ndc1_Nup PF09531.10 ETO17674.1 - 1.1 7.8 10.6 1.6 7.3 10.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AAA PF00004.29 ETO17675.1 - 0.049 14.1 0.2 0.22 12.0 0.2 2.2 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) YtxH PF12732.7 ETO17677.1 - 9.6 6.8 17.2 2.4 8.8 4.6 3.6 2 2 0 2 2 2 0 YtxH-like protein SRP-alpha_N PF04086.13 ETO17678.1 - 0.54 10.1 35.3 0.79 9.6 35.3 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Macoilin PF09726.9 ETO17678.1 - 1.4 7.4 43.5 2 6.9 43.5 1.3 1 0 0 1 1 1 0 Macoilin family WD40 PF00400.32 ETO17681.1 - 9.2e-37 124.4 20.0 2.3e-07 31.4 0.7 7.3 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17681.1 - 8.6e-12 45.2 0.5 0.078 13.3 0.0 4.8 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO17681.1 - 1e-10 40.9 4.9 0.011 14.4 0.8 5.8 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO17681.1 - 0.027 13.2 7.6 0.4 9.4 1.6 3.8 2 2 0 3 3 3 0 Nup133 N terminal like DUF4979 PF16351.5 ETO17681.1 - 0.81 9.9 4.0 32 4.7 0.1 3.5 2 1 2 4 4 4 0 Domain of unknown function (DUF4979) E2_bind PF08825.10 ETO17683.1 - 0.12 12.6 1.3 14 5.9 0.2 2.7 3 0 0 3 3 3 0 E2 binding domain Trypan_PARP PF05887.11 ETO17683.1 - 2.5 8.1 7.0 0.86 9.6 3.2 2.2 2 1 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF1340 PF07067.11 ETO17684.1 - 0.022 14.1 0.4 0.022 14.1 0.4 1.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1340) E_Pc_C PF06752.12 ETO17684.1 - 0.84 9.7 11.1 1.6 8.8 11.1 1.5 1 1 0 1 1 1 0 Enhancer of Polycomb C-terminus RsgI_N PF12791.7 ETO17685.1 - 0.05 13.5 0.3 0.096 12.6 0.3 1.4 1 0 0 1 1 1 0 Anti-sigma factor N-terminus DUF2076 PF09849.9 ETO17685.1 - 0.097 12.7 13.8 6.1 6.8 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Orf78 PF06024.12 ETO17685.1 - 0.1 12.9 10.8 0.23 11.8 2.2 2.7 2 0 0 2 2 2 0 Orf78 (ac78) P5-ATPase PF12409.8 ETO17685.1 - 0.35 11.0 4.9 0.21 11.7 1.0 2.3 2 0 0 2 2 2 0 P5-type ATPase cation transporter DUF2796 PF10986.8 ETO17685.1 - 2.5 8.1 20.1 1.9 8.4 8.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2796) AIF_C PF14721.6 ETO17685.1 - 3.2 8.1 7.2 1.4 9.3 0.2 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PIEZO PF15917.5 ETO17685.1 - 4.1 6.8 7.6 0.19 11.2 1.3 1.8 2 0 0 2 2 2 0 Piezo Methyltransf_12 PF08242.12 ETO17685.1 - 4.3 8.1 9.5 2.7 8.8 0.3 2.3 2 0 0 2 2 2 0 Methyltransferase domain Sporozoite_P67 PF05642.11 ETO17685.1 - 6.2 4.8 9.4 9.4 4.2 9.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen EphA2_TM PF14575.6 ETO17686.1 - 0.034 15.0 0.5 0.38 11.7 0.5 2.2 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain CSD PF00313.22 ETO17688.1 - 3.6e-08 33.1 0.1 9.9e-08 31.7 0.1 1.7 2 0 0 2 2 2 1 'Cold-shock' DNA-binding domain Exo_endo_phos PF03372.23 ETO17690.1 - 5.9e-09 35.8 0.0 9.1e-08 31.9 0.0 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Misat_Tub_SegII PF10644.9 ETO17690.1 - 0.095 13.0 3.1 1.7 9.0 0.0 2.7 2 0 0 2 2 2 0 Misato Segment II tubulin-like domain CD20 PF04103.15 ETO17691.1 - 0.0069 16.5 0.4 0.0069 16.5 0.4 3.0 3 1 0 3 3 3 1 CD20-like family Chi-conotoxin PF16981.5 ETO17691.1 - 0.2 11.9 0.2 0.2 11.9 0.2 2.4 2 0 0 2 2 2 0 chi-Conotoxin or t superfamily PH PF00169.29 ETO17692.1 - 1.4e-05 25.5 0.1 1.4e-05 25.5 0.1 2.7 4 0 0 4 4 4 1 PH domain Mito_fiss_reg PF05308.11 ETO17693.1 - 0.7 9.9 10.9 0.16 12.0 7.4 1.7 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF1180 PF06679.12 ETO17693.1 - 3.2 8.1 6.9 7.1 7.0 6.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DSPc PF00782.20 ETO17694.1 - 2.7e-30 104.9 0.1 2.7e-29 101.7 0.0 2.5 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO17694.1 - 3.2e-05 23.6 0.6 0.00016 21.3 0.0 2.2 2 0 0 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETO17694.1 - 0.0086 16.2 0.0 0.017 15.3 0.0 1.4 1 0 0 1 1 1 1 Inositol hexakisphosphate Rhodanese PF00581.20 ETO17694.1 - 0.0097 16.4 0.1 0.043 14.3 0.0 2.0 2 0 0 2 2 2 1 Rhodanese-like domain DUF2165 PF09933.9 ETO17694.1 - 0.077 13.0 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Predicted small integral membrane protein (DUF2165) ADIP PF11559.8 ETO17695.1 - 1.2e-05 25.5 13.3 0.0005 20.2 5.0 2.2 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding PI3K_P85_iSH2 PF16454.5 ETO17695.1 - 0.0042 16.7 4.8 0.0042 16.7 4.8 2.2 2 0 0 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain ZapB PF06005.12 ETO17695.1 - 0.0045 17.4 9.9 0.0051 17.2 6.7 2.5 2 1 0 2 2 2 1 Cell division protein ZapB Rab5-bind PF09311.11 ETO17695.1 - 0.0066 15.9 6.2 0.0088 15.5 6.2 1.3 1 0 0 1 1 1 1 Rabaptin-like protein HALZ PF02183.18 ETO17695.1 - 0.015 15.5 2.1 0.015 15.5 2.1 2.0 2 0 0 2 2 1 0 Homeobox associated leucine zipper Shugoshin_N PF07558.11 ETO17695.1 - 0.018 14.9 3.5 0.068 13.1 2.5 2.4 1 1 1 2 2 2 0 Shugoshin N-terminal coiled-coil region bZIP_2 PF07716.15 ETO17695.1 - 0.042 13.9 2.3 0.042 13.9 2.3 3.1 3 0 0 3 3 3 0 Basic region leucine zipper Mod_r PF07200.13 ETO17695.1 - 0.073 13.2 9.8 0.1 12.7 8.7 1.8 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Atg14 PF10186.9 ETO17695.1 - 0.076 12.1 15.5 0.088 11.9 15.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3606 PF12244.8 ETO17695.1 - 0.095 12.6 0.5 0.24 11.4 0.0 1.9 2 0 0 2 2 1 0 Protein of unknown function (DUF3606) KfrA_N PF11740.8 ETO17695.1 - 0.11 13.2 0.1 0.2 12.4 0.1 1.5 1 0 0 1 1 1 0 Plasmid replication region DNA-binding N-term DUF4694 PF15765.5 ETO17695.1 - 0.12 12.4 6.5 0.14 12.2 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4694) Histidinol_dh PF00815.20 ETO17695.1 - 0.18 10.8 2.0 0.19 10.7 1.5 1.3 1 1 0 1 1 1 0 Histidinol dehydrogenase DivIC PF04977.15 ETO17695.1 - 0.2 11.4 2.2 0.73 9.6 2.2 2.1 1 1 0 1 1 1 0 Septum formation initiator DUF1387 PF07139.11 ETO17695.1 - 0.26 11.0 17.3 0.32 10.7 17.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4477 PF14780.6 ETO17695.1 - 0.28 10.8 4.8 0.45 10.1 4.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4477) APG6_N PF17675.1 ETO17695.1 - 0.34 11.4 12.3 0.28 11.7 10.9 1.6 1 1 0 1 1 1 0 Apg6 coiled-coil region ApoO PF09769.9 ETO17695.1 - 0.35 10.8 1.4 2 8.4 1.4 2.2 1 1 0 1 1 1 0 Apolipoprotein O Golgin_A5 PF09787.9 ETO17695.1 - 0.35 10.3 13.0 0.43 10.0 13.0 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 Cortex-I_coil PF09304.10 ETO17695.1 - 0.36 11.1 9.9 0.17 12.1 5.1 2.4 1 1 2 3 3 3 0 Cortexillin I, coiled coil DUF3450 PF11932.8 ETO17695.1 - 0.48 9.7 4.5 0.39 10.0 2.2 1.8 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) Spc24 PF08286.11 ETO17695.1 - 0.82 9.9 8.4 2.1 8.6 7.3 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 JIP_LZII PF16471.5 ETO17695.1 - 0.94 9.7 8.8 0.12 12.6 2.6 2.4 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Tub_N PF16322.5 ETO17695.1 - 1 9.8 13.2 1.4 9.2 13.2 1.2 1 0 0 1 1 1 0 Tubby N-terminal ATG16 PF08614.11 ETO17695.1 - 3.5 7.8 14.9 0.099 12.9 6.5 2.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TMPIT PF07851.13 ETO17695.1 - 5.3 6.2 9.9 6.1 6.0 9.9 1.3 1 0 0 1 1 1 0 TMPIT-like protein MPTase-PolyVal PF18818.1 ETO17696.1 - 0.083 12.9 0.0 0.21 11.6 0.0 1.6 1 0 0 1 1 1 0 Metallopeptidase superfamily domain Pept_S41_N PF18294.1 ETO17696.1 - 0.17 11.9 5.7 1.2 9.2 1.7 2.8 2 0 0 2 2 2 0 Peptidase S41 N-terminal domain Ribosomal_S17_N PF16205.5 ETO17696.1 - 3.1 8.2 4.9 1.1 9.7 0.6 2.5 2 0 0 2 2 2 0 Ribosomal_S17 N-terminal EF-hand_1 PF00036.32 ETO17697.1 - 1.2e-35 118.4 20.9 2.4e-10 39.2 1.4 4.3 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO17697.1 - 3.4e-29 101.1 13.0 5.1e-15 55.7 3.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO17697.1 - 1.2e-27 93.4 15.6 7.5e-08 31.7 0.0 4.7 4 1 0 5 5 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO17697.1 - 3.1e-26 89.6 17.1 1.3e-08 33.9 0.5 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO17697.1 - 1.7e-24 85.4 20.3 2.7e-13 49.5 4.9 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ETO17697.1 - 3.9e-12 46.3 1.2 3.9e-05 23.9 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO17697.1 - 1.1e-10 41.8 2.9 0.00026 21.3 0.2 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO17697.1 - 3.7e-08 33.3 8.1 0.00043 20.2 0.3 3.1 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 ETO17697.1 - 1.9e-06 27.9 0.7 0.045 13.7 0.0 2.9 2 1 1 3 3 3 2 Tellurite resistance protein TerB Dockerin_1 PF00404.18 ETO17697.1 - 0.00029 20.9 5.8 0.12 12.6 0.6 3.9 3 1 0 3 3 3 2 Dockerin type I domain Caleosin PF05042.13 ETO17697.1 - 0.00052 20.0 2.7 0.097 12.6 0.0 3.7 1 1 1 3 3 3 1 Caleosin related protein EF-hand_14 PF17959.1 ETO17697.1 - 0.00087 19.6 0.8 1.4 9.3 0.1 2.6 2 1 0 2 2 2 2 EF-hand domain EF-hand_10 PF14788.6 ETO17697.1 - 0.0042 16.9 5.6 0.041 13.8 1.3 2.5 2 0 0 2 2 2 1 EF hand Binary_toxB PF03495.14 ETO17697.1 - 0.0073 16.5 0.3 4.2 7.6 0.0 2.6 2 0 0 2 2 2 1 Clostridial binary toxin B/anthrax toxin PA Ca-binding domain DUF3349 PF11829.8 ETO17697.1 - 0.023 15.4 2.6 1.3 9.8 0.1 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF3349) EF-hand_11 PF08976.11 ETO17697.1 - 0.033 15.1 0.4 31 5.5 0.0 3.0 1 1 2 3 3 3 0 EF-hand domain B5 PF03484.15 ETO17697.1 - 0.037 14.3 0.1 7.8 6.9 0.0 2.4 2 0 0 2 2 2 0 tRNA synthetase B5 domain DUF5580 PF17743.1 ETO17697.1 - 0.037 12.6 0.0 1.3 7.5 0.0 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5580) DUF1241 PF06840.11 ETO17697.1 - 0.069 12.8 0.1 2.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1241) PNISR PF15996.5 ETO17697.1 - 0.1 12.9 4.0 0.16 12.2 4.0 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR AEP1 PF17049.5 ETO17697.1 - 0.29 10.1 1.4 0.36 9.8 0.5 1.5 2 0 0 2 2 2 0 ATPase expression protein 1 DUF1521 PF07481.11 ETO17697.1 - 0.52 10.3 9.2 5.1 7.1 0.1 3.4 2 1 1 3 3 3 0 Domain of Unknown Function (DUF1521) FG-GAP PF01839.23 ETO17697.1 - 3.7 7.8 7.7 34 4.7 0.6 3.7 4 0 0 4 4 4 0 FG-GAP repeat EspA PF03433.13 ETO17697.1 - 8.9 6.1 9.0 3.1e+02 1.1 8.9 2.5 1 1 0 1 1 1 0 EspA-like secreted protein DUF3525 PF12039.8 ETO17698.1 - 0.26 10.0 1.3 0.31 9.7 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3525) Macoilin PF09726.9 ETO17698.1 - 1.8 7.0 8.2 1.7 7.1 8.2 1.1 1 0 0 1 1 1 0 Macoilin family ABC2_membrane_3 PF12698.7 ETO17698.1 - 3.8 6.5 4.4 4.5 6.3 4.4 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein AlbA_2 PF04326.14 ETO17699.1 - 8.1e-09 35.9 0.4 2.5e-08 34.3 0.0 2.1 2 0 0 2 2 2 1 Putative DNA-binding domain DUF4881 PF16222.5 ETO17699.1 - 0.11 12.4 0.0 0.23 11.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4881) TFIIA PF03153.13 ETO17699.1 - 0.36 10.8 23.0 0.49 10.3 23.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DHC_N2 PF08393.13 ETO17700.1 - 1.7e-117 392.9 14.8 1.7e-117 392.9 14.8 2.7 3 1 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 ETO17700.1 - 5.1e-36 124.3 0.1 1.4e-35 122.8 0.1 1.8 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region Meis_PKNOX_N PF16493.5 ETO17700.1 - 0.0021 18.4 4.9 0.049 14.0 0.0 4.4 3 0 0 3 3 3 1 N-terminal of Homeobox Meis and PKNOX1 AAA PF00004.29 ETO17700.1 - 0.012 16.1 0.3 0.06 13.8 0.0 2.4 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Plasmid_RAQPRD PF09686.10 ETO17700.1 - 0.013 15.6 0.2 0.27 11.5 0.0 3.3 3 0 0 3 3 3 0 Plasmid protein of unknown function (Plasmid_RAQPRD) AAA_7 PF12775.7 ETO17700.1 - 0.028 13.9 0.0 0.084 12.4 0.0 1.8 1 0 0 1 1 1 0 P-loop containing dynein motor region HK_sensor PF16750.5 ETO17700.1 - 0.03 14.6 0.1 0.14 12.5 0.1 2.1 1 0 0 1 1 1 0 Sensor domain of 2-component histidine kinase HsbA PF12296.8 ETO17700.1 - 0.046 14.2 0.2 2.1 8.8 0.0 3.4 3 0 0 3 3 3 0 Hydrophobic surface binding protein A DUF4476 PF14771.6 ETO17700.1 - 0.071 13.4 3.4 0.1 12.9 0.7 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) RNA_helicase PF00910.22 ETO17700.1 - 0.14 12.6 0.8 2.2 8.7 0.0 3.0 3 0 0 3 3 3 0 RNA helicase CHASE6_C PF17150.4 ETO17700.1 - 0.28 11.9 2.2 8.4 7.1 0.5 3.3 2 0 0 2 2 2 0 C-terminal domain of two-partite extracellular sensor domain AAA_6 PF12774.7 ETO17701.1 - 2.7e-112 375.0 0.0 3e-112 374.8 0.0 1.0 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_5 PF07728.14 ETO17701.1 - 9e-05 22.5 0.0 0.15 12.0 0.0 2.5 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) DUF853 PF05872.12 ETO17701.1 - 0.033 12.8 0.0 0.047 12.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AAA_7 PF12775.7 ETO17701.1 - 0.084 12.4 0.1 0.27 10.7 0.1 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region Golgin_A5 PF09787.9 ETO17703.1 - 0.038 13.5 1.3 0.055 12.9 1.3 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 CCM2_C PF16545.5 ETO17703.1 - 0.06 13.9 0.3 0.16 12.6 0.0 1.8 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology Pox_A_type_inc PF04508.12 ETO17703.1 - 0.1 12.5 0.7 0.37 10.7 0.7 2.0 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat GAS PF13851.6 ETO17703.1 - 0.11 11.9 1.4 0.23 10.8 0.6 1.9 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding G-alpha PF00503.20 ETO17705.1 - 3.8e-17 62.5 10.3 5.3e-17 62.0 10.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit CNDH2_N PF06278.11 ETO17705.1 - 0.024 14.9 0.4 0.13 12.4 0.0 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal TPR_5 PF12688.7 ETO17706.1 - 0.085 13.1 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 Tetratrico peptide repeat DUF334 PF03904.13 ETO17706.1 - 0.3 10.6 7.2 0.039 13.5 1.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF334) Serine_rich PF08824.10 ETO17706.1 - 0.39 10.7 7.9 0.76 9.8 3.0 2.9 2 1 1 3 3 3 0 Serine rich protein interaction domain Latarcin PF10279.9 ETO17706.1 - 1.5 9.3 4.3 28 5.2 0.2 3.5 3 0 0 3 3 3 0 Latarcin precursor EF-G-binding_N PF07299.11 ETO17706.1 - 2.5 8.7 10.0 8.2 7.0 0.8 4.4 3 1 0 3 3 3 0 Elongation factor G-binding protein, N-terminal Aida_N PF08910.10 ETO17706.1 - 2.6 8.5 5.2 33 4.9 1.9 3.3 3 1 0 3 3 3 0 Aida N-terminus CCDC-167 PF15188.6 ETO17706.1 - 4.2 7.8 10.8 0.72 10.2 2.2 3.4 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 Paramyxo_C PF01692.18 ETO17707.1 - 0.0053 16.2 0.4 0.013 14.9 0.4 1.6 1 0 0 1 1 1 1 Paramyxovirus non-structural protein C Tropomyosin_1 PF12718.7 ETO17708.1 - 0.0038 17.4 8.2 0.0098 16.1 8.2 1.7 1 1 0 1 1 1 1 Tropomyosin like TMF_TATA_bd PF12325.8 ETO17708.1 - 0.017 15.3 14.8 0.048 13.9 2.2 2.3 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3201 PF11447.8 ETO17708.1 - 0.07 12.7 0.1 0.093 12.3 0.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3201) IES5 PF17335.2 ETO17708.1 - 0.08 13.2 7.0 0.066 13.5 2.5 2.3 1 1 1 2 2 2 0 Ino80 complex subunit 5 Rx_N PF18052.1 ETO17708.1 - 0.084 13.2 0.8 0.084 13.2 0.8 2.3 1 1 1 2 2 2 0 Rx N-terminal domain TMF_DNA_bd PF12329.8 ETO17708.1 - 0.085 12.9 8.1 0.35 10.9 1.7 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding PspB PF06667.12 ETO17708.1 - 0.13 12.4 5.1 3.1 7.9 0.4 2.5 2 0 0 2 2 2 0 Phage shock protein B DUF3053 PF11254.8 ETO17708.1 - 0.14 11.7 7.1 0.044 13.4 2.6 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3053) HrpB7 PF09486.10 ETO17708.1 - 0.28 11.6 6.4 2.6 8.4 5.3 2.1 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF4763 PF15960.5 ETO17708.1 - 0.29 10.4 19.2 0.18 11.1 4.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Cep57_CLD_2 PF14197.6 ETO17708.1 - 0.29 11.2 13.1 0.76 9.9 3.0 3.1 3 1 1 4 4 3 0 Centrosome localisation domain of PPC89 KLRAQ PF10205.9 ETO17708.1 - 0.65 10.3 14.8 0.91 9.8 6.1 2.4 1 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein CENP-K PF11802.8 ETO17708.1 - 0.78 9.3 14.3 3.1 7.3 2.2 2.2 1 1 1 2 2 2 0 Centromere-associated protein K JAKMIP_CC3 PF16034.5 ETO17708.1 - 0.86 9.5 17.3 35 4.3 17.3 2.1 1 1 0 1 1 1 0 JAKMIP CC3 domain Cnn_1N PF07989.11 ETO17708.1 - 0.88 9.8 10.3 2.2 8.5 0.9 2.8 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 EMP24_GP25L PF01105.24 ETO17708.1 - 1.5 8.7 11.1 0.3 11.0 5.2 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD CorA PF01544.18 ETO17708.1 - 1.6 8.0 9.3 3.2 7.0 7.7 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF745 PF05335.13 ETO17708.1 - 2.4 7.8 9.6 4.5 7.0 2.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) DUF641 PF04859.12 ETO17708.1 - 3 8.2 10.5 14 6.0 9.9 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) ATG16 PF08614.11 ETO17708.1 - 3 8.0 16.2 0.81 9.9 5.2 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) BLOC1_2 PF10046.9 ETO17708.1 - 4.1 7.8 10.8 0.78 10.1 3.1 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HIP1_clath_bdg PF16515.5 ETO17708.1 - 6.3 7.5 15.6 3.4 8.4 5.8 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Jnk-SapK_ap_N PF09744.9 ETO17708.1 - 6.6 6.9 18.4 2 8.6 5.4 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 FliJ PF02050.16 ETO17708.1 - 6.8 6.9 19.1 6.4 7.0 0.8 2.6 1 1 1 2 2 2 0 Flagellar FliJ protein UPF0242 PF06785.11 ETO17708.1 - 7 6.7 16.4 1.4e+02 2.5 16.4 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus LMBR1 PF04791.16 ETO17708.1 - 9.2 5.0 10.1 10 4.9 10.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Atg14 PF10186.9 ETO17711.1 - 4.2e-05 22.8 21.4 5.3e-05 22.5 21.4 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Lant_dehydr_C PF14028.6 ETO17711.1 - 0.0049 16.4 1.6 0.0049 16.4 1.6 2.0 2 0 0 2 2 2 1 Lantibiotic biosynthesis dehydratase C-term TetR_C_34 PF17929.1 ETO17711.1 - 0.038 14.1 0.4 0.14 12.3 0.1 2.0 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Muted PF14942.6 ETO17711.1 - 0.17 12.2 39.6 1.1 9.6 15.8 2.4 2 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein AAA_13 PF13166.6 ETO17711.1 - 0.24 10.0 27.2 0.37 9.4 27.2 1.3 1 1 0 1 1 1 0 AAA domain Allexi_40kDa PF05549.11 ETO17711.1 - 0.28 10.6 13.9 1.6 8.2 1.4 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein BT1 PF03092.16 ETO17711.1 - 0.38 8.9 2.1 0.27 9.4 0.9 1.3 1 1 0 1 1 1 0 BT1 family CSG2 PF16965.5 ETO17711.1 - 1 8.2 7.3 0.41 9.5 5.0 1.4 1 1 1 2 2 2 0 Ceramide synthase regulator DUF1192 PF06698.11 ETO17711.1 - 1.4 9.1 11.3 3.9 7.6 0.9 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) DUF4041 PF13250.6 ETO17711.1 - 1.6 8.6 6.1 3.2 7.7 0.3 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4041) LUC7 PF03194.15 ETO17711.1 - 1.9 8.1 27.5 2.9 7.5 13.6 2.1 2 0 0 2 2 2 0 LUC7 N_terminus DUF3450 PF11932.8 ETO17711.1 - 3.4 6.9 30.6 0.084 12.2 7.5 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) Baculo_p24 PF05073.12 ETO17711.1 - 3.8 7.3 23.2 0.021 14.6 7.1 2.2 1 1 1 2 2 2 0 Baculovirus P24 capsid protein Tho2 PF11262.8 ETO17711.1 - 5.5 6.1 27.3 0.02 14.1 6.4 2.5 2 1 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 UPF0242 PF06785.11 ETO17711.1 - 7.1 6.7 39.2 9 6.3 14.3 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FAM76 PF16046.5 ETO17711.1 - 7.4 5.8 28.8 3.7 6.8 13.1 2.2 2 0 0 2 2 2 0 FAM76 protein FlgN PF05130.12 ETO17711.1 - 7.5 7.0 31.9 0.69 10.4 8.5 3.3 2 2 1 3 3 3 0 FlgN protein DSPc PF00782.20 ETO17712.1 - 1.7e-30 105.6 2.5 2.8e-30 104.8 0.0 2.4 2 1 1 3 3 3 1 Dual specificity phosphatase, catalytic domain Rhodanese PF00581.20 ETO17712.1 - 4.6e-07 30.3 1.1 0.00053 20.5 0.4 2.6 2 1 0 2 2 2 2 Rhodanese-like domain PTPlike_phytase PF14566.6 ETO17712.1 - 5.2e-06 26.7 0.1 1.2e-05 25.5 0.1 1.7 1 1 0 1 1 1 1 Inositol hexakisphosphate Init_tRNA_PT PF04179.12 ETO17712.1 - 1.3e-05 25.4 0.3 3.5e-05 24.1 0.0 1.9 2 0 0 2 2 2 1 Rit1 DUSP-like domain Ribonuc_L-PSP PF01042.21 ETO17712.1 - 0.011 15.7 0.1 0.02 14.9 0.1 1.4 1 0 0 1 1 1 0 Endoribonuclease L-PSP DUF2630 PF10944.8 ETO17712.1 - 0.075 13.5 2.4 0.17 12.4 0.0 2.7 4 0 0 4 4 4 0 Protein of unknown function (DUF2630) ATP13 PF12921.7 ETO17713.1 - 0.051 13.4 0.1 0.25 11.2 0.1 2.2 1 0 0 1 1 1 0 Mitochondrial ATPase expression Tyrosinase PF00264.20 ETO17714.1 - 0.013 15.8 8.7 0.017 15.4 8.7 1.2 1 0 0 1 1 1 0 Common central domain of tyrosinase DUF2052 PF09747.9 ETO17714.1 - 0.082 13.0 17.6 0.1 12.7 17.6 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Serine_protease PF18405.1 ETO17714.1 - 0.12 11.5 1.4 0.89 8.7 1.4 2.0 1 1 0 1 1 1 0 Gammaproteobacterial serine protease Methyltransf_12 PF08242.12 ETO17714.1 - 0.19 12.5 0.7 0.52 11.1 0.1 1.9 1 1 1 2 2 2 0 Methyltransferase domain DUF4628 PF15429.6 ETO17714.1 - 0.24 11.0 13.3 0.31 10.7 13.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4628) AAA_11 PF13086.6 ETO17714.1 - 0.34 10.6 12.4 0.41 10.4 12.4 1.1 1 0 0 1 1 1 0 AAA domain FYDLN_acid PF09538.10 ETO17714.1 - 0.39 11.4 20.8 6.3 7.5 20.8 2.1 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Usp PF00582.26 ETO17714.1 - 1.1 9.8 3.8 2.2 8.8 3.8 1.5 1 0 0 1 1 1 0 Universal stress protein family Presenilin PF01080.17 ETO17714.1 - 1.5 7.5 15.5 1.9 7.2 15.5 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO17714.1 - 2.1 8.3 9.1 2.6 8.1 9.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Paramyxo_ncap PF00973.19 ETO17714.1 - 3.3 6.5 13.6 3.9 6.3 13.6 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF913 PF06025.12 ETO17714.1 - 4.2 6.2 10.1 5.2 5.9 10.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.12 ETO17716.1 - 2.3 6.3 9.5 2.7 6.1 9.5 1.0 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO17716.1 - 4.2 6.0 9.0 5.1 5.7 9.0 1.1 1 0 0 1 1 1 0 Presenilin TctB PF07331.11 ETO17717.1 - 0.0028 17.9 0.8 0.0041 17.4 0.8 1.2 1 0 0 1 1 1 1 Tripartite tricarboxylate transporter TctB family MtrF PF09472.10 ETO17717.1 - 0.2 11.1 0.1 0.2 11.1 0.1 1.9 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) B56 PF01603.20 ETO17718.1 - 0.072 12.1 0.3 0.086 11.8 0.3 1.1 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) SOG2 PF10428.9 ETO17718.1 - 0.083 12.1 15.7 0.087 12.0 15.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein FSA_C PF10479.9 ETO17718.1 - 1.9 6.5 13.4 2.2 6.3 13.4 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Apt1 PF10351.9 ETO17718.1 - 2.6 6.8 10.1 3.5 6.4 10.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ETO17718.1 - 7.6 6.3 17.2 9.5 6.0 17.2 1.1 1 0 0 1 1 1 0 SPX domain Guanylate_cyc PF00211.20 ETO17719.1 - 2.4e-08 33.8 0.0 8.1e-08 32.1 0.0 1.7 2 0 0 2 2 2 1 Adenylate and Guanylate cyclase catalytic domain Asp-Al_Ex PF06826.12 ETO17719.1 - 0.049 13.4 0.3 0.081 12.7 0.3 1.3 1 0 0 1 1 1 0 Predicted Permease Membrane Region VARLMGL PF14383.6 ETO17719.1 - 0.094 12.3 0.2 0.18 11.4 0.2 1.4 1 0 0 1 1 1 0 DUF761-associated sequence motif ETRAMP PF09716.10 ETO17720.1 - 0.031 14.3 0.0 0.12 12.4 0.0 2.2 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) TPR_19 PF14559.6 ETO17721.1 - 5.7e-10 39.6 17.2 6.7e-05 23.3 0.1 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17721.1 - 5.4e-07 29.2 18.6 0.25 11.5 0.1 9.4 11 0 0 11 11 11 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17721.1 - 0.00016 21.9 7.1 0.15 12.5 0.1 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17721.1 - 0.0028 17.7 19.5 0.99 9.8 0.0 8.1 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17721.1 - 0.038 13.8 16.7 27 4.8 0.0 8.6 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17721.1 - 0.044 14.4 1.6 75 4.1 0.0 4.9 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17721.1 - 0.044 14.4 11.3 2.4 9.0 0.0 6.3 8 0 0 8 8 8 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17721.1 - 0.057 13.6 0.5 0.057 13.6 0.5 7.6 6 2 1 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETO17721.1 - 0.089 12.1 10.6 0.57 9.5 0.2 4.4 6 0 0 6 6 6 0 MalT-like TPR region TPR_2 PF07719.17 ETO17722.1 - 8.4e-09 34.9 15.9 0.047 13.8 0.1 8.7 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17722.1 - 2.9e-08 33.2 1.2 0.0073 16.3 0.1 6.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17722.1 - 3.6e-08 33.6 1.4 2.7 9.1 0.2 8.0 8 3 3 11 11 9 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17722.1 - 1.1e-06 29.1 16.2 0.6 10.7 0.2 7.2 5 3 3 8 8 7 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO17722.1 - 2.9e-06 27.4 22.0 0.004 17.3 2.0 6.5 5 2 1 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO17722.1 - 3.4e-06 27.6 1.6 0.17 12.6 0.1 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17722.1 - 7.6e-05 22.9 17.1 0.18 12.1 0.2 7.2 6 3 1 9 9 9 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17722.1 - 9.9e-05 22.3 21.1 0.34 11.2 0.0 9.9 10 1 1 11 11 10 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17722.1 - 0.0001 22.7 11.2 2.7 8.8 0.0 7.6 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17722.1 - 0.0002 21.1 11.4 0.66 9.9 0.1 6.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_20 PF14561.6 ETO17722.1 - 0.00051 20.3 6.9 3.7 8.0 0.3 5.2 5 1 1 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17722.1 - 0.0081 16.5 2.0 3.7 8.2 0.0 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17722.1 - 0.092 12.6 3.9 18 5.4 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 ETO17722.1 - 1.4 8.8 15.4 0.22 11.4 6.5 3.6 4 1 0 4 4 4 0 Region in Clathrin and VPS ANAPC4_WD40 PF12894.7 ETO17723.1 - 9.5e-05 22.6 2.2 0.0022 18.3 0.1 2.5 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain ERG4_ERG24 PF01222.17 ETO17723.1 - 0.013 14.2 0.1 0.017 13.9 0.1 1.2 1 0 0 1 1 1 0 Ergosterol biosynthesis ERG4/ERG24 family HNOBA PF07701.14 ETO17723.1 - 0.03 13.7 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 Heme NO binding associated RNase_PH PF01138.21 ETO17724.1 - 2.8e-25 89.3 0.5 4.4e-25 88.7 0.5 1.3 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RGS PF00615.19 ETO17725.1 - 0.0059 16.9 1.8 0.034 14.4 1.8 2.3 1 1 0 1 1 1 1 Regulator of G protein signaling domain Acyl-CoA_dh_1 PF00441.24 ETO17726.1 - 4.6e-40 137.3 0.2 5.6e-40 137.0 0.2 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO17726.1 - 2.7e-13 50.3 0.1 3.3e-13 50.1 0.1 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Helicase_C PF00271.31 ETO17727.1 - 5.6e-29 100.7 0.7 1.5e-28 99.3 0.3 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO17727.1 - 2.5e-06 27.4 0.0 4.3e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 DEAD/DEAH box helicase ERCC3_RAD25_C PF16203.5 ETO17727.1 - 0.00044 19.5 0.3 0.00061 19.1 0.3 1.2 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase SURF6 PF04935.12 ETO17728.1 - 0.098 12.4 13.1 0.12 12.1 13.1 1.1 1 0 0 1 1 1 0 Surfeit locus protein 6 PI3K_1B_p101 PF10486.9 ETO17728.1 - 0.1 10.4 10.9 0.11 10.2 10.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Peptidase_S64 PF08192.11 ETO17728.1 - 0.45 8.9 10.3 0.52 8.7 10.3 1.0 1 0 0 1 1 1 0 Peptidase family S64 Roughex PF06020.11 ETO17728.1 - 0.94 8.5 11.5 1.1 8.3 11.5 1.0 1 0 0 1 1 1 0 Drosophila roughex protein Nop14 PF04147.12 ETO17728.1 - 2.2 6.4 21.2 2.5 6.2 21.2 1.0 1 0 0 1 1 1 0 Nop14-like family Peptidase_C37 PF05416.12 ETO17728.1 - 2.3 6.7 7.3 2.5 6.5 7.3 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase DNA_pol_phi PF04931.13 ETO17728.1 - 6.1 4.8 22.4 7 4.6 22.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.10 ETO17728.1 - 7.3 5.8 21.0 8.7 5.6 21.0 1.0 1 0 0 1 1 1 0 BUD22 Harakiri PF15196.6 ETO17729.1 - 0.11 12.9 0.3 0.25 11.8 0.3 1.6 1 0 0 1 1 1 0 Activator of apoptosis harakiri Neur_chan_memb PF02932.16 ETO17729.1 - 0.58 10.2 11.2 1.6e+02 2.2 11.2 2.4 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GRP PF07172.11 ETO17729.1 - 9 7.1 25.0 3.9 8.2 21.5 2.2 2 0 0 2 2 2 0 Glycine rich protein family PAC4 PF16093.5 ETO17730.1 - 0.0077 16.4 0.6 0.019 15.2 0.6 1.7 1 1 0 1 1 1 1 Proteasome assembly chaperone 4 NusG_II PF07009.11 ETO17730.1 - 0.028 14.6 2.7 0.33 11.2 0.8 2.4 2 0 0 2 2 2 0 NusG domain II Ras PF00071.22 ETO17731.1 - 3.5e-31 108.0 0.8 4e-31 107.8 0.8 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO17731.1 - 1e-08 35.4 0.0 1.6e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO17731.1 - 0.0011 18.5 0.1 0.0012 18.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO17731.1 - 0.0023 17.5 0.0 0.0028 17.2 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain PurL_C PF16904.5 ETO17731.1 - 0.055 13.8 0.0 0.098 13.0 0.0 1.5 1 0 0 1 1 1 0 Phosphoribosylformylglycinamidine synthase II C-terminus Mito_fiss_reg PF05308.11 ETO17733.1 - 2.8 8.0 10.8 4.4 7.3 10.8 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator Herpes_DNAp_acc PF04929.12 ETO17733.1 - 8 5.3 9.6 8.8 5.2 9.6 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor CN_hydrolase PF00795.22 ETO17734.1 - 2e-09 37.2 0.0 2.6e-09 36.8 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase TRAF_BIRC3_bd PF16673.5 ETO17735.1 - 0.0033 17.2 2.5 0.32 10.8 0.0 3.0 2 1 1 3 3 3 2 TNF receptor-associated factor BIRC3 binding domain Lectin_N PF03954.14 ETO17735.1 - 0.059 13.1 1.3 0.1 12.3 1.3 1.5 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Rubrerythrin PF02915.17 ETO17735.1 - 0.66 10.4 10.3 0.95 9.9 10.3 1.2 1 0 0 1 1 1 0 Rubrerythrin zf-C2H2_3rep PF18868.1 ETO17735.1 - 5 7.8 6.7 11 6.8 3.6 2.6 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Mpp10 PF04006.12 ETO17736.1 - 0.34 9.3 23.0 0.34 9.3 23.0 1.0 1 0 0 1 1 1 0 Mpp10 protein Zip PF02535.22 ETO17736.1 - 1.8 7.7 3.7 1.9 7.6 3.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Nop14 PF04147.12 ETO17736.1 - 3.7 5.6 32.6 4.1 5.5 32.6 1.0 1 0 0 1 1 1 0 Nop14-like family PTPRCAP PF15713.5 ETO17736.1 - 4.8 7.5 23.4 6.9 7.0 23.4 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Presenilin PF01080.17 ETO17736.1 - 5.9 5.6 5.0 6.4 5.4 5.0 1.0 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETO17736.1 - 6.3 4.8 4.5 7.1 4.6 4.5 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SAPS PF04499.15 ETO17736.1 - 8.9 5.0 12.4 8.7 5.0 12.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Phage_P2_GpE PF06528.12 ETO17737.1 - 0.099 12.2 0.5 0.17 11.5 0.1 1.6 2 0 0 2 2 2 0 Phage P2 GpE Com_YlbF PF06133.11 ETO17738.1 - 0.051 14.2 6.3 0.11 13.2 6.3 1.6 1 0 0 1 1 1 0 Control of competence regulator ComK, YlbF/YmcA ALMT PF11744.8 ETO17738.1 - 5.1 5.8 5.9 6.2 5.5 5.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter GREB1 PF15782.5 ETO17738.1 - 5.9 3.9 8.2 6.1 3.8 8.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 ETO17738.1 - 6.5 5.4 7.0 7.4 5.2 7.0 1.1 1 0 0 1 1 1 0 Presenilin CBS PF00571.28 ETO17739.1 - 1.7e-07 31.5 0.1 0.0021 18.5 0.0 2.9 2 1 0 2 2 2 2 CBS domain Voltage_CLC PF00654.20 ETO17740.1 - 3.9e-22 79.0 2.0 4.8e-22 78.7 2.0 1.1 1 0 0 1 1 1 1 Voltage gated chloride channel DUF1700 PF08006.11 ETO17740.1 - 3.1 7.3 7.6 0.2 11.2 1.5 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF1700) Adaptin_binding PF10199.9 ETO17741.1 - 8.8e-11 42.5 1.9 8.8e-11 42.5 1.9 2.0 2 0 0 2 2 2 1 Alpha and gamma adaptin binding protein p34 SID-1_RNA_chan PF13965.6 ETO17741.1 - 0.045 12.2 3.1 0.018 13.4 1.0 1.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 PWWP PF00855.17 ETO17741.1 - 0.49 10.8 0.0 0.49 10.8 0.0 3.1 4 0 0 4 4 4 0 PWWP domain FAM176 PF14851.6 ETO17741.1 - 0.9 9.2 4.9 0.2 11.3 0.9 1.9 2 0 0 2 2 2 0 FAM176 family C2 PF00168.30 ETO17742.1 - 1.1e-10 41.8 1.2 2.6e-10 40.5 1.2 1.7 1 0 0 1 1 1 1 C2 domain DivIC PF04977.15 ETO17742.1 - 0.00028 20.6 5.9 0.00033 20.4 4.7 1.8 1 1 0 1 1 1 1 Septum formation initiator NRBF2 PF08961.10 ETO17742.1 - 0.0056 16.3 2.9 0.011 15.4 2.9 1.5 1 0 0 1 1 1 1 Nuclear receptor-binding factor 2, autophagy regulator bZIP_1 PF00170.21 ETO17742.1 - 0.012 15.6 3.9 0.012 15.6 3.9 2.1 3 0 0 3 3 3 0 bZIP transcription factor SlyX PF04102.12 ETO17742.1 - 0.094 13.3 10.3 0.47 11.1 10.3 2.1 1 1 0 1 1 1 0 SlyX TolA_bind_tri PF16331.5 ETO17742.1 - 0.18 11.9 8.2 0.28 11.3 8.2 1.3 1 0 0 1 1 1 0 TolA binding protein trimerisation DUF3450 PF11932.8 ETO17742.1 - 0.18 11.1 6.0 0.26 10.5 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) GIT_CC PF16559.5 ETO17742.1 - 0.47 10.4 11.4 1.4 8.8 4.5 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor UPF0449 PF15136.6 ETO17742.1 - 0.71 10.4 9.1 1.2 9.6 9.0 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0449 C2 PF00168.30 ETO17743.1 - 0.028 14.7 0.0 0.078 13.3 0.0 1.7 1 1 1 2 2 2 0 C2 domain Ion_trans PF00520.31 ETO17744.1 - 6.5e-40 136.9 7.2 9.4e-40 136.4 7.2 1.1 1 0 0 1 1 1 1 Ion transport protein DUF4079 PF13301.6 ETO17744.1 - 0.005 17.0 1.5 0.044 13.9 0.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF4079) Apis_Csd PF11671.8 ETO17744.1 - 0.14 12.2 0.7 0.22 11.5 0.7 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein Auxin_inducible PF02519.14 ETO17745.1 - 0.071 13.3 0.0 0.17 12.1 0.0 1.6 1 0 0 1 1 1 0 Auxin responsive protein PT-HINT PF07591.11 ETO17746.1 - 5.1e-07 30.0 0.2 2.9e-06 27.6 0.2 1.9 1 1 0 1 1 1 1 Pretoxin HINT domain Intein_splicing PF14890.6 ETO17746.1 - 6.9e-07 29.3 0.1 5.3e-06 26.4 0.1 1.9 1 1 0 1 1 1 1 Intein splicing domain AXH PF08517.12 ETO17746.1 - 4.8e-06 27.1 0.1 8.6e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) YajC PF02699.15 ETO17746.1 - 0.012 15.4 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit DUF373 PF04123.13 ETO17747.1 - 0.19 11.2 8.4 0.27 10.6 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF373) HlyD_2 PF12700.7 ETO17748.1 - 1.2 7.8 2.9 1.7 7.3 2.9 1.2 1 0 0 1 1 1 0 HlyD family secretion protein DUF908 PF06012.12 ETO17749.1 - 0.017 14.6 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) THDPS_N PF14790.6 ETO17749.1 - 0.052 13.4 0.0 0.072 12.9 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal PKD_channel PF08016.12 ETO17750.1 - 0.0078 14.9 1.9 0.014 14.1 0.1 1.9 2 0 0 2 2 2 1 Polycystin cation channel Glycophorin_A PF01102.18 ETO17750.1 - 0.071 13.4 0.2 1.6 9.0 0.1 2.5 2 1 1 3 3 3 0 Glycophorin A TMEM132D_C PF15706.5 ETO17750.1 - 0.12 12.2 0.2 0.25 11.2 0.2 1.6 1 1 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term SDA1 PF05285.12 ETO17751.1 - 0.048 13.1 39.4 0.057 12.8 39.4 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO17751.1 - 6.6 4.8 35.6 9.4 4.3 35.6 1.3 1 0 0 1 1 1 0 Nop14-like family DUF3915 PF13054.6 ETO17751.1 - 9.3 6.3 16.0 0.075 13.0 6.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3915) TFIIF_alpha PF05793.12 ETO17751.1 - 10 4.6 42.6 14 4.1 42.6 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) UPF0172 PF03665.13 ETO17752.1 - 2.1e-09 37.7 2.7 2.6e-09 37.4 2.7 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0172) Arginase PF00491.21 ETO17753.1 - 4.6e-38 131.3 0.0 5.5e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Arginase family Aminotran_4 PF01063.19 ETO17754.1 - 1.5e-12 47.9 0.0 2.1e-12 47.4 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV ATP-synt_J PF04911.12 ETO17754.1 - 0.065 12.8 0.0 0.12 11.9 0.0 1.4 1 0 0 1 1 1 0 ATP synthase j chain Aminotran_4 PF01063.19 ETO17755.1 - 8.2e-09 35.6 0.0 9.1e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Amino-transferase class IV Pkinase PF00069.25 ETO17756.1 - 4.1e-23 82.1 0.1 7.3e-23 81.3 0.1 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17756.1 - 2.7e-12 46.5 0.1 3e-12 46.4 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO17756.1 - 0.00022 20.7 0.1 0.00027 20.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO17756.1 - 0.0065 16.0 0.1 0.012 15.2 0.1 1.4 1 1 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ETO17756.1 - 0.013 14.3 0.0 0.014 14.2 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pox_A51 PF04948.13 ETO17756.1 - 0.013 14.3 0.3 0.015 14.1 0.3 1.0 1 0 0 1 1 1 0 Poxvirus A51 protein SIX1_SD PF16878.5 ETO17757.1 - 0.11 13.0 1.0 0.18 12.3 0.1 1.8 2 0 0 2 2 2 0 Transcriptional regulator, SIX1, N-terminal SD domain Anoctamin PF04547.12 ETO17758.1 - 2.4e-11 43.1 2.1 2.4e-11 43.1 2.1 1.9 2 1 0 2 2 2 1 Calcium-activated chloride channel APAF1_C PF17908.1 ETO17758.1 - 0.095 12.7 3.3 0.12 12.3 0.6 2.2 2 1 0 2 2 2 0 APAF-1 helical domain Endonuc-PvuII PF09225.10 ETO17759.1 - 0.075 12.8 0.0 0.12 12.2 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease PvuII DUF2052 PF09747.9 ETO17760.1 - 0.00052 20.2 23.8 0.023 14.8 10.0 3.0 3 0 0 3 3 3 2 Coiled-coil domain containing protein (DUF2052) Nop14 PF04147.12 ETO17760.1 - 0.019 13.2 21.0 0.033 12.4 6.7 2.3 2 0 0 2 2 2 0 Nop14-like family AAA_23 PF13476.6 ETO17760.1 - 0.052 14.1 14.1 0.21 12.1 2.1 2.6 2 1 0 2 2 2 0 AAA domain Mak16 PF04874.14 ETO17760.1 - 0.13 12.9 33.3 0.083 13.5 9.4 3.6 4 0 0 4 4 3 0 Mak16 protein C-terminal region DUF2072 PF09845.9 ETO17760.1 - 0.27 11.5 14.2 2.8 8.2 3.6 2.8 2 0 0 2 2 2 0 Zn-ribbon containing protein CDC45 PF02724.14 ETO17760.1 - 0.3 9.3 22.1 0.74 8.0 5.0 2.6 2 1 0 2 2 2 0 CDC45-like protein FAM76 PF16046.5 ETO17760.1 - 0.41 10.0 16.2 0.064 12.6 2.4 3.1 3 0 0 3 3 3 0 FAM76 protein Radial_spoke PF04712.12 ETO17760.1 - 0.42 9.5 22.5 1.4 7.8 5.8 2.5 2 0 0 2 2 2 0 Radial spokehead-like protein Folliculin PF11704.8 ETO17760.1 - 2.6 7.9 12.9 0.88 9.4 0.3 3.3 3 0 0 3 3 3 0 Vesicle coat protein involved in Golgi to plasma membrane transport Spore_coat_CotO PF14153.6 ETO17760.1 - 2.9 7.8 18.7 5.8 6.8 7.4 2.6 2 0 0 2 2 2 0 Spore coat protein CotO Connexin PF00029.19 ETO17760.1 - 3.3 7.4 8.9 12 5.6 0.2 2.4 2 0 0 2 2 2 0 Connexin RNA_pol_3_Rpc31 PF11705.8 ETO17760.1 - 5.1 7.3 26.9 0.74 10.0 5.5 3.2 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 Nop25 PF09805.9 ETO17760.1 - 5.3 7.5 24.5 2.7 8.5 4.7 2.9 3 0 0 3 3 3 0 Nucleolar protein 12 (25kDa) TRAP_alpha PF03896.16 ETO17760.1 - 5.6 6.1 13.2 3.6 6.7 0.5 2.4 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit CPSF100_C PF13299.6 ETO17760.1 - 5.8 7.1 18.9 2.1 8.5 4.2 3.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DUF4604 PF15377.6 ETO17760.1 - 6.8 7.1 22.0 4.3 7.7 9.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) RPS31 PF17067.5 ETO17761.1 - 0.01 16.0 0.6 0.036 14.2 0.4 2.0 1 1 1 2 2 2 0 Ribosomal protein S31e DUF5393 PF17371.2 ETO17761.1 - 0.91 7.6 7.7 1.3 7.1 7.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5393) CENP-B_dimeris PF09026.10 ETO17761.1 - 2.9 8.3 16.9 2.8 8.4 3.6 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RNase_H2_suC PF08615.11 ETO17761.1 - 3.4 7.8 12.6 7.2e+02 0.3 12.5 2.9 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Hydin_ADK PF17213.3 ETO17761.1 - 9.9 6.4 11.7 5.7 7.2 7.7 2.0 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Orf78 PF06024.12 ETO17763.1 - 0.012 15.9 4.4 0.012 15.9 4.4 3.5 3 1 1 4 4 4 0 Orf78 (ac78) DUF2039 PF10217.9 ETO17763.1 - 0.019 15.3 1.6 0.019 15.3 1.6 2.7 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2039) CFIA_Pcf11 PF11526.8 ETO17763.1 - 0.041 14.4 2.4 0.041 14.4 2.4 3.3 2 1 1 3 3 3 0 Subunit of cleavage factor IA Pcf11 TFIIF_alpha PF05793.12 ETO17763.1 - 0.1 11.1 22.5 0.14 10.8 22.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LAP1C PF05609.12 ETO17763.1 - 0.12 11.5 12.2 0.17 11.0 12.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CENP-B_dimeris PF09026.10 ETO17763.1 - 1 9.8 18.8 21 5.6 0.0 3.4 2 1 1 3 3 3 0 Centromere protein B dimerisation domain Nop14 PF04147.12 ETO17763.1 - 1.2 7.3 18.1 1.6 6.9 18.1 1.1 1 0 0 1 1 1 0 Nop14-like family Utp14 PF04615.13 ETO17763.1 - 1.4 7.4 24.7 1.7 7.1 24.7 1.0 1 0 0 1 1 1 0 Utp14 protein FAM60A PF15396.6 ETO17763.1 - 2.4 8.1 17.4 6.8 6.6 11.0 2.1 2 0 0 2 2 2 0 Protein Family FAM60A PH_5 PF15405.6 ETO17763.1 - 3.2 7.9 10.6 2 8.5 0.3 2.7 2 1 1 3 3 3 0 Pleckstrin homology domain PBP1_TM PF14812.6 ETO17763.1 - 7.6 7.0 0.0 7.6 7.0 0.0 3.5 3 1 1 4 4 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ribosomal_S2 PF00318.20 ETO17764.1 - 0.029 13.6 0.2 0.036 13.3 0.2 1.1 1 0 0 1 1 1 0 Ribosomal protein S2 Kinesin PF00225.23 ETO17765.1 - 1.8e-30 106.1 14.4 6.5e-16 58.2 0.0 4.7 3 2 0 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 ETO17765.1 - 8.1e-11 42.1 4.8 8.2e-09 35.6 0.0 3.5 3 0 0 3 3 3 2 Microtubule binding eIF-5a PF01287.20 ETO17765.1 - 0.56 10.4 4.4 6.2 7.0 2.2 2.7 2 0 0 2 2 2 0 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold AAA PF00004.29 ETO17766.1 - 1e-20 74.5 0.0 1.8e-20 73.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO17766.1 - 6.6e-08 32.2 0.0 3.4e-07 30.0 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 ETO17766.1 - 0.0031 17.5 0.0 0.0072 16.3 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain CCDC24 PF15669.5 ETO17766.1 - 0.19 11.6 0.7 0.29 11.0 0.0 1.5 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 24 family DnaT PF17948.1 ETO17767.1 - 0.079 12.7 0.5 0.3 10.8 0.3 2.0 2 0 0 2 2 2 0 DnaT DNA-binding domain RNA_binding PF01877.17 ETO17770.1 - 0.032 14.5 0.1 0.035 14.4 0.1 1.2 1 0 0 1 1 1 0 RNA binding WW_1 PF18507.1 ETO17770.1 - 0.13 12.0 0.3 0.4 10.4 0.3 1.7 1 0 0 1 1 1 0 WW domain Methyltransf_12 PF08242.12 ETO17771.1 - 1.6e-10 41.6 0.0 3.3e-10 40.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO17771.1 - 2.6e-10 40.9 0.0 4.5e-10 40.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO17771.1 - 9.5e-10 39.0 0.0 1.6e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO17771.1 - 2.8e-06 27.2 0.0 7.5e-06 25.8 0.0 1.7 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ETO17771.1 - 2.4e-05 23.9 0.0 6.1e-05 22.6 0.0 1.8 1 1 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.6 ETO17771.1 - 7e-05 22.7 0.0 8.9e-05 22.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain RrnaAD PF00398.20 ETO17771.1 - 0.00067 18.8 0.0 0.00094 18.3 0.0 1.2 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_PK PF05891.12 ETO17771.1 - 0.011 15.2 0.0 0.021 14.3 0.0 1.6 1 1 0 1 1 1 0 AdoMet dependent proline di-methyltransferase MTS PF05175.14 ETO17771.1 - 0.017 14.7 0.0 0.091 12.3 0.0 2.1 2 1 0 2 2 2 0 Methyltransferase small domain Dot_icm_IcmQ PF09475.10 ETO17771.1 - 0.12 11.8 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Dot/Icm secretion system protein (dot_icm_IcmQ) Ion_trans PF00520.31 ETO17772.1 - 0.00036 19.8 9.2 0.00036 19.8 9.2 1.7 2 0 0 2 2 2 1 Ion transport protein LRR19-TM PF15176.6 ETO17772.1 - 0.99 9.4 4.2 0.92 9.5 0.6 2.3 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Ion_trans PF00520.31 ETO17773.1 - 2.6e-15 56.3 20.0 1.6e-10 40.6 14.0 2.5 2 1 0 2 2 2 2 Ion transport protein Coilin_N PF15862.5 ETO17773.1 - 1 9.2 9.2 2.8 7.8 9.2 1.7 1 0 0 1 1 1 0 Coilin N-terminus Toxin_YhaV PF11663.8 ETO17773.1 - 3.8 7.5 10.4 0.87 9.6 5.1 2.3 2 1 0 2 2 2 0 Toxin with endonuclease activity, of toxin-antitoxin system Ion_trans PF00520.31 ETO17774.1 - 4.5e-19 68.7 17.6 6.5e-19 68.1 17.6 1.2 1 0 0 1 1 1 1 Ion transport protein CdvA PF18822.1 ETO17774.1 - 0.0044 16.9 0.4 0.0079 16.0 0.4 1.4 1 0 0 1 1 1 1 CdvA-like coiled-coil domain DUF2981 PF11200.8 ETO17774.1 - 0.5 10.1 5.0 0.096 12.4 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) Hid1 PF12722.7 ETO17775.1 - 3.7 5.5 17.3 5 5.1 17.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SPX PF03105.19 ETO17775.1 - 5.7 6.7 36.4 16 5.2 36.4 1.8 1 1 0 1 1 1 0 SPX domain Mic1 PF07035.12 ETO17776.1 - 6.8e-08 32.4 0.0 9.5e-06 25.4 0.0 2.3 2 0 0 2 2 2 2 Colon cancer-associated protein Mic1-like FAM176 PF14851.6 ETO17776.1 - 0.12 12.0 1.0 0.26 10.9 0.2 1.8 2 0 0 2 2 2 0 FAM176 family Syntaxin-6_N PF09177.11 ETO17777.1 - 0.012 16.1 3.2 0.018 15.6 3.2 1.3 1 0 0 1 1 1 0 Syntaxin 6, N-terminal DnaI_N PF07319.11 ETO17777.1 - 0.22 12.2 6.8 0.28 11.9 6.8 1.2 1 0 0 1 1 1 0 Primosomal protein DnaI N-terminus Drf_GBD PF06371.13 ETO17777.1 - 0.55 9.8 5.5 0.62 9.6 5.5 1.2 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain U79_P34 PF03064.16 ETO17777.1 - 0.66 9.3 11.8 0.7 9.2 11.8 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Methyltrn_RNA_3 PF02598.17 ETO17778.1 - 0.021 14.3 0.0 0.027 14.0 0.0 1.1 1 0 0 1 1 1 0 Putative RNA methyltransferase GAS PF13851.6 ETO17779.1 - 0.0019 17.5 8.1 0.0019 17.5 8.1 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding PI3K_P85_iSH2 PF16454.5 ETO17779.1 - 0.0026 17.4 13.9 0.0026 17.4 13.9 1.8 1 1 1 2 2 2 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Atg14 PF10186.9 ETO17779.1 - 0.0051 15.9 11.9 0.0064 15.6 11.9 1.0 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF730 PF05325.11 ETO17779.1 - 0.0053 16.8 3.7 0.0091 16.0 1.8 2.0 1 1 1 2 2 2 1 Protein of unknown function (DUF730) PEPcase_2 PF14010.6 ETO17779.1 - 0.0059 15.2 5.3 0.0087 14.6 5.3 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase DHR10 PF18595.1 ETO17779.1 - 0.012 15.7 10.0 0.012 15.7 10.0 2.1 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain CBP_BcsQ PF06564.12 ETO17779.1 - 0.017 14.6 1.2 0.02 14.4 1.2 1.3 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsQ Tropomyosin PF00261.20 ETO17779.1 - 0.021 14.2 23.2 0.029 13.7 23.2 1.2 1 0 0 1 1 1 0 Tropomyosin Maelstrom PF13017.6 ETO17779.1 - 0.085 12.5 1.2 0.13 11.9 1.2 1.2 1 0 0 1 1 1 0 piRNA pathway germ-plasm component AAA_31 PF13614.6 ETO17779.1 - 0.14 12.1 1.9 0.26 11.2 0.1 1.8 1 1 1 2 2 2 0 AAA domain HALZ PF02183.18 ETO17779.1 - 0.21 11.9 12.5 1.4 9.2 0.5 3.5 3 0 0 3 3 3 0 Homeobox associated leucine zipper Spc7 PF08317.11 ETO17779.1 - 0.42 9.4 21.4 0.57 9.0 21.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein LLC1 PF14945.6 ETO17779.1 - 1.3 9.6 6.2 0.4 11.3 2.4 2.0 1 1 0 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein FPP PF05911.11 ETO17779.1 - 1.5 6.9 22.2 1.7 6.7 22.2 1.0 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil CENP-F_leu_zip PF10473.9 ETO17779.1 - 1.5 8.9 26.5 10 6.1 15.8 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF745 PF05335.13 ETO17779.1 - 2.7 7.7 14.9 3.5 7.3 14.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Herpes_BLRF2 PF05812.12 ETO17779.1 - 4.3 7.5 11.9 1.5e+02 2.6 11.9 2.3 1 1 0 1 1 1 0 Herpesvirus BLRF2 protein Golgin_A5 PF09787.9 ETO17779.1 - 4.7 6.6 26.7 14 5.0 26.7 1.6 1 1 0 1 1 1 0 Golgin subfamily A member 5 HMMR_N PF15905.5 ETO17779.1 - 4.8 6.6 26.2 24 4.3 26.2 1.8 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal Mt_ATP-synt_D PF05873.12 ETO17779.1 - 4.9 7.0 10.4 0.92 9.3 3.3 2.1 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) UPF0242 PF06785.11 ETO17779.1 - 5.7 7.0 26.2 2.1 8.4 8.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus TMPIT PF07851.13 ETO17779.1 - 6.9 5.8 14.4 1.6 7.9 9.9 1.8 1 1 1 2 2 2 0 TMPIT-like protein NPV_P10 PF05531.12 ETO17779.1 - 7.1 7.2 9.4 1.3 9.5 0.7 2.7 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein KxDL PF10241.9 ETO17779.1 - 8.5 6.7 13.3 0.18 12.1 2.1 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein FUSC PF04632.12 ETO17779.1 - 9.5 4.6 6.3 10 4.5 6.3 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF5532 PF17673.1 ETO17780.1 - 0.097 12.7 1.6 0.1 12.7 0.6 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5532) RGS PF00615.19 ETO17781.1 - 0.003 17.8 0.7 1.8 8.8 0.0 2.7 2 1 0 2 2 2 2 Regulator of G protein signaling domain Zip PF02535.22 ETO17781.1 - 2.2 7.4 13.6 0.093 11.9 8.0 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter Ferlin_C PF16165.5 ETO17781.1 - 9.2 6.2 9.9 13 5.8 1.2 2.7 2 0 0 2 2 2 0 Ferlin C-terminus Lactamase_B_6 PF16661.5 ETO17782.1 - 5.4e-18 65.1 0.1 1.2e-17 64.0 0.1 1.5 1 1 1 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 ETO17782.1 - 3.5e-10 40.2 0.0 1.7e-09 37.9 0.0 1.9 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETO17782.1 - 0.00082 18.9 0.1 0.003 17.1 0.1 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain PDEase_II PF02112.15 ETO17782.1 - 0.032 13.3 0.1 0.056 12.6 0.1 1.3 1 0 0 1 1 1 0 cAMP phosphodiesterases class-II Lactamase_B_3 PF13483.6 ETO17782.1 - 0.15 11.9 0.1 0.38 10.6 0.1 1.8 1 1 0 1 1 1 0 Beta-lactamase superfamily domain NAD_binding_10 PF13460.6 ETO17783.1 - 6.4e-20 71.8 0.0 1e-19 71.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Sacchrp_dh_NADP PF03435.18 ETO17783.1 - 5.6e-05 23.4 0.0 9.2e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_4 PF07993.12 ETO17783.1 - 8.2e-05 21.9 0.0 0.00021 20.6 0.0 1.7 2 0 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 ETO17783.1 - 0.00049 19.2 0.0 0.00079 18.5 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NmrA PF05368.13 ETO17783.1 - 0.0006 19.4 0.0 0.001 18.6 0.0 1.4 1 0 0 1 1 1 1 NmrA-like family DapB_N PF01113.20 ETO17783.1 - 0.0041 17.2 0.0 0.0067 16.6 0.0 1.4 1 0 0 1 1 1 1 Dihydrodipicolinate reductase, N-terminus Epimerase PF01370.21 ETO17783.1 - 0.038 13.4 0.0 0.06 12.8 0.0 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family KSHV_K1 PF11049.8 ETO17783.1 - 0.06 13.3 0.0 0.14 12.1 0.0 1.7 1 0 0 1 1 1 0 Glycoprotein K1 of Kaposi's sarcoma-associated herpes virus Caps_synth PF05704.12 ETO17783.1 - 0.063 12.7 0.1 0.092 12.1 0.1 1.2 1 0 0 1 1 1 0 Capsular polysaccharide synthesis protein GDP_Man_Dehyd PF16363.5 ETO17783.1 - 0.074 12.4 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 ETO17783.1 - 0.18 12.3 0.0 0.36 11.3 0.0 1.5 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain NUFIP1 PF10453.9 ETO17784.1 - 1.1e-08 34.8 4.6 1.1e-08 34.8 4.6 2.4 2 0 0 2 2 2 1 Nuclear fragile X mental retardation-interacting protein 1 (NUFIP1) Peptidase_S28 PF05577.12 ETO17784.1 - 0.027 13.3 1.6 0.048 12.4 1.6 1.3 1 0 0 1 1 1 0 Serine carboxypeptidase S28 SOBP PF15279.6 ETO17785.1 - 7.5 7.1 18.6 8.8 6.8 18.6 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Dapper PF15268.6 ETO17785.1 - 8.8 5.0 22.5 10 4.9 22.5 1.1 1 0 0 1 1 1 0 Dapper Nop53 PF07767.11 ETO17786.1 - 0.19 11.1 22.7 0.22 10.9 22.7 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) BSP_II PF05432.11 ETO17786.1 - 0.34 10.6 17.3 0.43 10.2 17.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Radical_SAM_N PF08497.10 ETO17786.1 - 0.83 8.8 5.0 1 8.5 5.0 1.1 1 0 0 1 1 1 0 Radical SAM N-terminal Presenilin PF01080.17 ETO17786.1 - 1.2 7.8 16.4 1.4 7.6 16.4 1.2 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 ETO17786.1 - 1.2 8.4 8.5 1.4 8.2 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LAP1C PF05609.12 ETO17786.1 - 1.6 7.7 17.3 1.8 7.6 17.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Membralin PF09746.9 ETO17786.1 - 3.4 6.6 10.5 3.7 6.5 10.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein CDC45 PF02724.14 ETO17786.1 - 4.6 5.4 16.6 5.4 5.2 16.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Dsh_C PF12316.8 ETO17786.1 - 9.6 6.5 13.8 13 6.1 13.8 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal AAA_2 PF07724.14 ETO17787.1 - 1.1e-28 100.4 0.3 1.4e-28 100.2 0.3 1.1 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA PF00004.29 ETO17787.1 - 3e-08 34.2 0.1 3.4e-08 34.0 0.1 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ATPgrasp_Ter PF15632.6 ETO17787.1 - 0.13 12.0 0.2 0.21 11.3 0.2 1.2 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon DUF2457 PF10446.9 ETO17788.1 - 0.047 12.8 8.2 0.052 12.7 8.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2884 PF11101.8 ETO17788.1 - 0.3 10.6 5.2 0.1 12.1 2.8 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2884) OmpH PF03938.14 ETO17788.1 - 0.67 10.3 11.0 0.41 11.0 5.7 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) TolA_bind_tri PF16331.5 ETO17788.1 - 0.87 9.7 14.4 0.66 10.1 10.7 2.4 2 1 0 2 2 2 0 TolA binding protein trimerisation NOA36 PF06524.12 ETO17788.1 - 1.7 7.9 7.8 2.4 7.4 7.8 1.3 1 0 0 1 1 1 0 NOA36 protein FAM76 PF16046.5 ETO17788.1 - 5.6 6.2 9.0 0.38 10.1 2.3 1.9 1 1 1 2 2 2 0 FAM76 protein M_domain PF12938.7 ETO17789.1 - 0.013 15.4 1.4 0.013 15.4 1.4 3.1 2 1 1 3 3 3 0 M domain of GW182 zf-C4pol PF14260.6 ETO17789.1 - 6.5 7.3 7.8 5.5 7.5 1.2 2.9 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta SAB PF04382.13 ETO17789.1 - 6.7 6.9 9.4 1.8 8.7 5.7 2.0 2 0 0 2 2 2 0 SAB domain Fez1 PF06818.15 ETO17789.1 - 10 6.5 36.0 1.8 9.0 22.3 2.8 2 1 0 2 2 2 0 Fez1 Sad1_UNC PF07738.13 ETO17790.1 - 2.5e-05 24.3 1.9 0.0016 18.5 1.9 3.1 1 1 0 1 1 1 1 Sad1 / UNC-like C-terminal Sas10_Utp3 PF04000.15 ETO17790.1 - 0.018 15.7 0.1 0.084 13.5 0.0 2.2 2 0 0 2 2 2 0 Sas10/Utp3/C1D family SlyX PF04102.12 ETO17791.1 - 0.01 16.4 5.7 0.015 15.9 0.9 2.8 2 1 1 3 3 3 0 SlyX DUF658 PF04936.12 ETO17791.1 - 0.13 12.0 4.4 0.16 11.7 3.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF658) DUF4407 PF14362.6 ETO17791.1 - 0.23 10.8 4.0 0.3 10.4 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CLZ PF16526.5 ETO17791.1 - 0.3 11.5 8.5 1.3 9.4 2.1 2.7 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 ETO17791.1 - 0.56 10.4 10.5 3.3 7.9 10.5 2.1 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family CRA PF06589.11 ETO17792.1 - 0.0023 18.0 2.2 0.0034 17.5 2.2 1.3 1 0 0 1 1 1 1 Circumsporozoite-related antigen (CRA) WBP-1 PF11669.8 ETO17793.1 - 0.017 15.7 0.8 0.029 15.0 0.3 1.6 2 0 0 2 2 2 0 WW domain-binding protein 1 DUF4500 PF14937.6 ETO17793.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4500) ETRAMP PF09716.10 ETO17793.1 - 0.18 11.9 5.6 0.44 10.6 5.6 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Hydin_ADK PF17213.3 ETO17794.1 - 4 7.7 14.2 5.5 7.2 14.2 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CDC45 PF02724.14 ETO17794.1 - 5.8 5.1 18.2 6.5 4.9 18.2 1.3 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 ETO17795.1 - 2.9e-39 135.0 0.0 3.6e-39 134.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17795.1 - 4.5e-19 68.8 0.0 5.4e-19 68.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO17795.1 - 0.00027 20.3 0.1 0.00043 19.7 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO17795.1 - 0.0018 17.1 0.0 0.0024 16.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO17795.1 - 0.0034 16.7 0.0 0.0045 16.3 0.0 1.2 1 0 0 1 1 1 1 Kinase-like FTA2 PF13095.6 ETO17795.1 - 0.0046 16.6 0.0 0.0069 16.0 0.0 1.3 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ETO17795.1 - 0.036 13.0 0.1 0.041 12.8 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 ETO17795.1 - 0.044 13.4 0.1 0.078 12.6 0.1 1.4 1 0 0 1 1 1 0 RIO1 family APH PF01636.23 ETO17795.1 - 0.098 12.6 0.1 0.17 11.8 0.1 1.4 1 1 0 1 1 1 0 Phosphotransferase enzyme family DUF3738 PF12543.8 ETO17795.1 - 0.11 12.7 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3738) RecR PF02132.15 ETO17795.1 - 0.13 11.8 0.1 0.31 10.6 0.1 1.5 1 0 0 1 1 1 0 RecR protein N-glycanase_C PF09113.10 ETO17797.1 - 0.027 14.3 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 0 Peptide-N-glycosidase F, C terminal CAF20 PF17052.5 ETO17797.1 - 0.16 12.1 3.1 0.18 12.0 1.5 1.7 1 1 0 2 2 2 0 Cap associated factor Cytochrom_B561 PF03188.16 ETO17798.1 - 3.4e-08 33.7 2.1 3.4e-08 33.7 2.1 1.7 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 DOMON PF03351.17 ETO17798.1 - 1.7e-05 25.1 0.1 2.9e-05 24.3 0.1 1.4 1 0 0 1 1 1 1 DOMON domain SdpI PF13630.6 ETO17798.1 - 0.017 15.3 13.8 0.024 14.8 1.7 2.7 2 0 0 2 2 2 0 SdpI/YhfL protein family DUF4079 PF13301.6 ETO17798.1 - 0.32 11.1 5.7 0.18 12.0 3.3 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4079) PI3Ka PF00613.20 ETO17799.1 - 3.8e-45 153.5 2.0 7.9e-45 152.5 2.0 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETO17799.1 - 2.1e-41 142.4 0.1 7.9e-40 137.2 0.1 2.5 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ETO17799.1 - 1.7e-13 50.7 0.0 3.8e-13 49.6 0.0 1.6 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ETO17799.1 - 7.1e-13 48.7 0.0 3.1e-12 46.6 0.0 2.1 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain GIT_CC PF16559.5 ETO17800.1 - 0.0093 15.8 1.6 4.4 7.2 0.1 2.9 2 0 0 2 2 2 2 GIT coiled-coil Rho guanine nucleotide exchange factor Mis14 PF08641.12 ETO17800.1 - 3.4 8.0 10.9 0.16 12.3 3.1 2.3 2 0 0 2 2 2 0 Kinetochore protein Mis14 like Glyco_hydro_31 PF01055.26 ETO17801.1 - 4.1e-14 52.6 0.0 4.6e-14 52.4 0.0 1.0 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF4203 PF13886.6 ETO17802.1 - 1.4e-17 64.0 14.1 1.6e-17 63.9 14.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4203) Holin_2-3 PF13272.6 ETO17802.1 - 0.01 16.1 0.7 0.034 14.4 0.2 2.0 1 1 1 2 2 2 0 Putative 2/3 transmembrane domain holin DUF2897 PF11446.8 ETO17802.1 - 0.33 10.9 2.0 0.31 11.0 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2897) CTNNB1_binding PF08347.11 ETO17803.1 - 0.0043 17.3 0.3 0.0043 17.3 0.3 1.1 1 0 0 1 1 1 1 N-terminal CTNNB1 binding Spore_IV_A PF09547.10 ETO17803.1 - 0.0057 15.7 0.2 0.0068 15.4 0.2 1.0 1 0 0 1 1 1 1 Stage IV sporulation protein A (spore_IV_A) NARP1 PF12569.8 ETO17803.1 - 0.02 13.8 3.6 0.025 13.5 3.6 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Presenilin PF01080.17 ETO17803.1 - 0.21 10.3 0.8 0.22 10.3 0.8 1.1 1 0 0 1 1 1 0 Presenilin fn3 PF00041.21 ETO17804.1 - 0.022 15.1 2.1 0.12 12.7 0.0 2.8 3 0 0 3 3 3 0 Fibronectin type III domain CRF PF00473.17 ETO17804.1 - 0.12 12.4 0.0 0.29 11.2 0.0 1.6 1 0 0 1 1 1 0 Corticotropin-releasing factor family DUF2771 PF10969.8 ETO17805.1 - 0.26 11.3 1.9 0.39 10.7 0.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2771) WD40 PF00400.32 ETO17806.1 - 9.9e-56 184.4 21.1 1.2e-09 38.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17806.1 - 1.4e-16 60.5 2.0 0.027 14.8 0.1 6.0 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO17806.1 - 1.2e-09 38.0 2.6 0.0021 17.4 0.1 3.3 2 1 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO17806.1 - 2e-09 36.9 0.4 0.45 9.4 0.0 5.3 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO17806.1 - 3.7e-06 25.9 1.1 0.11 11.1 0.0 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO17806.1 - 9.2e-05 22.3 2.7 16 5.6 0.0 5.9 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO17806.1 - 0.00026 19.6 0.2 0.04 12.5 0.1 2.5 2 1 0 2 2 2 1 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO17806.1 - 0.00068 18.5 0.1 0.068 11.9 0.0 3.6 2 2 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO17806.1 - 0.001 19.2 0.3 4.3 7.4 0.0 3.9 2 2 2 4 4 4 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO17806.1 - 0.0015 18.2 0.0 0.0072 15.9 0.0 2.1 1 1 1 2 2 2 1 PQQ-like domain Nucleoporin_N PF08801.11 ETO17806.1 - 0.0053 15.6 6.2 0.26 10.0 0.1 3.5 1 1 1 2 2 2 1 Nup133 N terminal like PQQ PF01011.21 ETO17806.1 - 0.013 15.4 0.1 8.5 6.5 0.0 4.1 5 0 0 5 5 5 0 PQQ enzyme repeat Frtz PF11768.8 ETO17806.1 - 0.021 13.2 0.0 1.9 6.7 0.0 2.3 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 ETO17806.1 - 0.03 13.4 1.8 1.9 7.5 0.2 2.8 1 1 0 2 2 2 0 Coatomer WD associated region HPS6 PF15702.5 ETO17806.1 - 0.039 11.9 0.0 7.9 4.3 0.0 3.2 1 1 3 4 4 4 0 Hermansky-Pudlak syndrome 6 protein Ret2_MD PF18528.1 ETO17806.1 - 0.079 13.4 0.2 6.2 7.3 0.0 3.2 3 1 0 3 3 3 0 RNA editing 3' terminal uridylyl transferase 2 middle domain DUF371 PF04027.13 ETO17806.1 - 2.3 8.2 4.3 13 5.8 0.1 3.7 2 2 0 3 3 3 0 Domain of unknown function (DUF371) Proteasome_A_N PF10584.9 ETO17806.1 - 6.4 6.6 7.6 61 3.4 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Ion_trans PF00520.31 ETO17807.1 - 2.7e-06 26.8 5.4 3.3e-06 26.5 5.4 1.1 1 0 0 1 1 1 1 Ion transport protein Collagen PF01391.18 ETO17808.1 - 7.2e-06 25.7 1.7 1.2e-05 24.9 1.7 1.3 1 0 0 1 1 1 1 Collagen triple helix repeat (20 copies) TonB_N PF16031.5 ETO17808.1 - 0.013 16.0 6.8 0.013 16.0 6.8 3.9 5 1 0 5 5 5 0 TonB polyproline region Trypan_PARP PF05887.11 ETO17808.1 - 0.31 11.0 40.1 0.14 12.1 20.6 2.7 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) NOA36 PF06524.12 ETO17808.1 - 0.87 8.8 13.5 3.4 6.9 13.5 2.0 1 0 0 1 1 1 0 NOA36 protein Conotoxin PF02950.17 ETO17808.1 - 3.6 8.7 0.0 3.6 8.7 0.0 4.0 3 1 0 3 3 3 0 Conotoxin LUC7 PF03194.15 ETO17810.1 - 2.9e-19 69.7 1.5 3.4e-19 69.5 1.5 1.0 1 0 0 1 1 1 1 LUC7 N_terminus Seryl_tRNA_N PF02403.22 ETO17810.1 - 0.015 15.5 2.0 0.028 14.7 2.0 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain BLOC1_2 PF10046.9 ETO17810.1 - 0.016 15.5 2.2 0.033 14.5 2.2 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C2H2_2 PF12756.7 ETO17810.1 - 0.018 15.3 0.1 0.034 14.5 0.1 1.4 1 0 0 1 1 1 0 C2H2 type zinc-finger (2 copies) DUF4175 PF13779.6 ETO17810.1 - 0.3 8.9 1.8 0.3 9.0 1.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF5542 PF17696.1 ETO17810.1 - 0.79 9.9 2.7 0.56 10.4 0.2 2.0 3 0 0 3 3 3 0 Family of unknown function (DUF5542) DHR10 PF18595.1 ETO17810.1 - 5.3 7.1 10.0 0.39 10.8 1.8 2.5 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DHHC PF01529.20 ETO17812.1 - 3.8e-31 107.9 6.9 3.8e-31 107.9 6.9 2.9 2 1 0 2 2 2 1 DHHC palmitoyltransferase ADH_N PF08240.12 ETO17812.1 - 1.1 9.2 6.7 1.3 8.9 4.6 2.1 2 0 0 2 2 2 0 Alcohol dehydrogenase GroES-like domain Aldo_ket_red PF00248.21 ETO17813.1 - 6.9e-08 32.0 0.2 9.9e-08 31.5 0.2 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Intron_maturas2 PF01348.21 ETO17813.1 - 0.0095 15.9 0.9 0.015 15.3 0.5 1.6 1 1 1 2 2 2 1 Type II intron maturase WWE PF02825.20 ETO17814.1 - 0.019 15.5 0.2 0.061 13.9 0.2 1.9 1 1 0 1 1 1 0 WWE domain STAG PF08514.11 ETO17816.1 - 0.055 13.4 0.0 0.17 11.8 0.0 1.8 1 0 0 1 1 1 0 STAG domain YqaH PF17448.2 ETO17817.1 - 0.13 12.6 0.3 4 7.8 0.0 3.1 1 1 1 2 2 2 0 Uncharacterized YqaH-like Sec8_exocyst PF04048.14 ETO17818.1 - 0.03 14.2 0.6 0.052 13.4 0.2 1.6 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Importin_rep_2 PF18786.1 ETO17818.1 - 0.37 10.7 0.2 0.37 10.7 0.2 2.1 3 0 0 3 3 3 0 Importin 13 repeat INSIG PF07281.12 ETO17819.1 - 0.12 12.1 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) Presenilin PF01080.17 ETO17820.1 - 1.5 7.5 3.6 1.5 7.5 3.6 1.0 1 0 0 1 1 1 0 Presenilin DUF547 PF04784.14 ETO17822.1 - 0.0041 17.1 2.7 0.0083 16.2 2.7 1.7 1 1 0 1 1 1 1 Protein of unknown function, DUF547 DUF938 PF06080.12 ETO17823.1 - 2e-36 125.7 0.0 7.5e-36 123.8 0.0 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF938) Scs3p PF10261.9 ETO17823.1 - 0.069 12.6 0.4 0.11 11.9 0.4 1.3 1 0 0 1 1 1 0 Inositol phospholipid synthesis and fat-storage-inducing TM Methyltransf_23 PF13489.6 ETO17823.1 - 0.15 11.9 0.0 1.1 9.1 0.0 2.1 2 0 0 2 2 2 0 Methyltransferase domain AMP-binding PF00501.28 ETO17824.1 - 1.5e-16 60.1 0.7 2.2e-16 59.5 0.7 1.3 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO17824.1 - 2.1e-09 38.2 0.1 3e-09 37.7 0.1 1.2 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain Imm42 PF15593.6 ETO17824.1 - 0.15 12.5 2.1 1.2 9.6 0.3 2.0 1 1 1 2 2 2 0 Immunity protein 42 HSP70 PF00012.20 ETO17825.1 - 8.5e-10 37.4 9.2 6.2e-05 21.4 0.0 3.3 2 1 1 3 3 3 2 Hsp70 protein RNase_H2_suC PF08615.11 ETO17825.1 - 5.2 7.2 6.1 5.7 7.1 3.6 2.4 2 1 0 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) DSBA PF01323.20 ETO17826.1 - 7.9e-10 38.8 0.0 8.6e-10 38.7 0.0 1.0 1 0 0 1 1 1 1 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ETO17826.1 - 4.9e-05 23.5 0.0 5.8e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_3 PF13192.6 ETO17826.1 - 0.00045 20.2 0.0 0.0011 19.0 0.0 1.7 2 0 0 2 2 2 1 Thioredoxin domain DisA-linker PF10635.9 ETO17826.1 - 0.03 14.1 0.1 0.041 13.6 0.1 1.2 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region U5_2-snRNA_bdg PF10597.9 ETO17826.1 - 0.13 12.3 0.0 0.18 11.9 0.0 1.2 1 0 0 1 1 1 0 U5-snRNA binding site 2 of PrP8 Carboxyl_trans PF01039.22 ETO17827.1 - 6.8e-67 226.2 0.0 3e-33 115.2 0.0 2.1 2 0 0 2 2 2 2 Carboxyl transferase domain DUF1640 PF07798.11 ETO17828.1 - 0.00058 20.0 4.4 0.38 10.8 0.0 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF1640) DUF87 PF01935.17 ETO17828.1 - 0.011 15.8 1.0 0.012 15.7 1.0 1.3 1 0 0 1 1 1 0 Helicase HerA, central domain TMEM247 PF15444.6 ETO17828.1 - 0.014 15.4 1.3 0.016 15.3 1.3 1.1 1 0 0 1 1 1 0 Transmembrane protein 247 Helo_like_N PF17111.5 ETO17828.1 - 0.02 14.3 6.7 0.048 13.0 1.0 2.0 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins TadF PF16964.5 ETO17828.1 - 0.028 14.2 0.9 0.031 14.0 0.9 1.2 1 0 0 1 1 1 0 Putative tight adherence pilin protein F Mod_r PF07200.13 ETO17828.1 - 0.21 11.7 7.8 0.27 11.3 7.8 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein LUC7 PF03194.15 ETO17828.1 - 0.45 10.1 9.0 0.54 9.9 9.0 1.2 1 0 0 1 1 1 0 LUC7 N_terminus Lig_chan PF00060.26 ETO17828.1 - 0.46 10.3 2.5 0.35 10.7 0.4 1.7 1 1 0 2 2 2 0 Ligand-gated ion channel HR1 PF02185.16 ETO17828.1 - 0.78 9.9 9.9 1.4 9.1 3.2 3.1 2 2 0 2 2 2 0 Hr1 repeat DUF2120 PF09893.9 ETO17828.1 - 0.78 9.8 4.9 0.37 10.9 1.0 1.9 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) SpoOE-like PF09388.10 ETO17828.1 - 3.8 7.5 8.9 0.23 11.4 1.7 2.5 2 2 2 4 4 4 0 Spo0E like sporulation regulatory protein TMF_DNA_bd PF12329.8 ETO17828.1 - 4.6 7.3 19.0 1.8 8.6 3.8 3.3 3 1 1 4 4 3 0 TATA element modulatory factor 1 DNA binding ZapB PF06005.12 ETO17828.1 - 7.9 7.0 13.0 1.3e+02 3.1 11.7 2.8 1 1 0 1 1 1 0 Cell division protein ZapB AMPK1_CBM PF16561.5 ETO17830.1 - 5.6e-22 77.8 0.6 9e-22 77.1 0.6 1.3 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase PapC_N PF13954.6 ETO17830.1 - 0.027 14.5 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 PapC N-terminal domain Abhydrolase_2 PF02230.16 ETO17830.1 - 0.031 14.1 0.0 0.045 13.5 0.0 1.2 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase DUF2353 PF09789.9 ETO17831.1 - 0.017 14.5 3.3 0.019 14.3 3.3 1.2 1 0 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) Tho2 PF11262.8 ETO17831.1 - 0.09 12.0 5.4 0.12 11.6 5.4 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Serinc PF03348.15 ETO17832.1 - 0.00042 19.4 1.3 0.00054 19.0 1.3 1.1 1 0 0 1 1 1 1 Serine incorporator (Serinc) DUF3785 PF12653.7 ETO17832.1 - 0.12 12.5 0.4 0.12 12.5 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3785) GWT1 PF06423.12 ETO17832.1 - 0.21 11.7 1.8 0.55 10.3 0.4 2.0 2 0 0 2 2 2 0 GWT1 YMF19 PF02326.15 ETO17832.1 - 0.79 10.6 11.8 10 7.0 0.0 2.5 2 1 0 2 2 2 0 Plant ATP synthase F0 DUF3139 PF11337.8 ETO17832.1 - 6 7.6 12.4 2.6e+02 2.4 12.4 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) Glyco_transf_4 PF13439.6 ETO17834.1 - 1.2e-11 44.9 0.0 1.9e-11 44.2 0.0 1.3 1 1 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ETO17834.1 - 0.00097 19.6 0.0 0.0011 19.4 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Glyco_trans_4_2 PF13477.6 ETO17834.1 - 0.0051 16.8 0.1 0.098 12.7 0.1 2.0 1 1 0 1 1 1 1 Glycosyl transferase 4-like YjeF_N PF03853.15 ETO17835.1 - 1.2e-13 51.3 0.0 1.3e-13 51.2 0.0 1.0 1 0 0 1 1 1 1 YjeF-related protein N-terminus Yippee-Mis18 PF03226.14 ETO17836.1 - 0.036 14.3 1.2 0.42 10.8 0.7 2.3 1 1 1 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DUF3379 PF11859.8 ETO17836.1 - 0.044 13.1 0.2 0.069 12.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3379) RuvA_C PF07499.13 ETO17836.1 - 0.068 13.6 1.8 0.14 12.6 1.8 1.6 1 0 0 1 1 1 0 RuvA, C-terminal domain Ribosomal_L22 PF00237.19 ETO17836.1 - 0.075 13.3 2.6 0.16 12.2 2.6 1.5 1 0 0 1 1 1 0 Ribosomal protein L22p/L17e G-alpha PF00503.20 ETO17837.1 - 1.6e-18 67.0 2.2 2.1e-18 66.6 2.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit ubiquitin PF00240.23 ETO17838.1 - 4e-18 64.9 0.0 1.6e-17 63.0 0.0 2.2 1 0 0 1 1 1 1 Ubiquitin family Intein_splicing PF14890.6 ETO17838.1 - 2e-07 31.0 4.4 1.9e-06 27.9 4.4 2.6 1 1 0 1 1 1 1 Intein splicing domain Rad60-SLD PF11976.8 ETO17838.1 - 5.2e-07 29.4 0.0 1.6e-06 27.8 0.0 1.9 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Hint PF01079.20 ETO17838.1 - 4.1e-05 23.2 0.0 7.6e-05 22.3 0.0 1.4 1 0 0 1 1 1 1 Hint module PT-HINT PF07591.11 ETO17838.1 - 0.00087 19.6 0.4 0.00087 19.6 0.4 3.0 4 0 0 4 4 4 1 Pretoxin HINT domain UN_NPL4 PF11543.8 ETO17838.1 - 0.033 14.7 0.3 0.23 12.0 0.0 2.6 3 0 0 3 3 3 0 Nuclear pore localisation protein NPL4 MAP17 PF15807.5 ETO17838.1 - 1.1 9.5 6.2 0.092 13.0 1.2 1.7 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF3947 PF13135.6 ETO17839.1 - 0.00084 19.5 3.0 0.0021 18.2 3.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3947) LdpA_C PF12617.8 ETO17841.1 - 0.019 14.6 0.2 0.055 13.1 0.1 1.8 2 0 0 2 2 2 0 Iron-Sulfur binding protein C terminal NOA36 PF06524.12 ETO17842.1 - 0.0027 17.1 15.6 0.0035 16.7 15.6 1.3 1 0 0 1 1 1 1 NOA36 protein GEMIN8 PF15348.6 ETO17842.1 - 0.01 16.2 0.2 0.017 15.4 0.1 1.4 1 1 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 Cwf_Cwc_15 PF04889.12 ETO17842.1 - 0.01 15.6 19.9 0.021 14.6 19.9 1.5 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Nucleo_P87 PF07267.11 ETO17842.1 - 1.3 7.8 11.8 1.7 7.4 11.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CDC27 PF09507.10 ETO17842.1 - 1.9 7.8 17.7 2.3 7.5 17.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ETO17842.1 - 2 6.5 17.7 2.2 6.4 17.7 1.2 1 0 0 1 1 1 0 Nop14-like family GCIP PF13324.6 ETO17842.1 - 2.3 7.8 7.7 4.6 6.8 7.7 1.6 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting PBP1_TM PF14812.6 ETO17842.1 - 8.9 6.8 22.9 1.2 9.6 17.8 2.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NACHT PF05729.12 ETO17843.1 - 5.9e-12 45.8 0.1 2.8e-11 43.6 0.0 2.3 2 0 0 2 2 2 1 NACHT domain HEAT_2 PF13646.6 ETO17843.1 - 6e-12 45.8 0.0 0.0022 18.4 0.0 5.6 2 2 3 6 6 6 3 HEAT repeats HEAT PF02985.22 ETO17843.1 - 5.6e-11 41.7 7.6 0.037 14.3 0.0 7.6 7 0 0 7 7 7 3 HEAT repeat Cnd1 PF12717.7 ETO17843.1 - 1.7e-07 31.4 21.4 3.5e-06 27.1 5.4 5.0 2 2 2 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Ank_3 PF13606.6 ETO17843.1 - 1.4e-06 28.2 0.4 0.00061 20.0 0.0 3.7 3 0 0 3 3 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO17843.1 - 3.4e-06 27.6 0.6 2.2e-05 24.9 0.0 2.7 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) HEAT_EZ PF13513.6 ETO17843.1 - 1.4e-05 25.5 1.2 0.0037 17.7 0.0 4.2 3 2 2 5 5 5 1 HEAT-like repeat Ank_5 PF13857.6 ETO17843.1 - 4.5e-05 23.6 0.2 0.00033 20.9 0.1 2.5 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO17843.1 - 7.8e-05 23.1 0.5 0.00041 20.9 0.3 2.6 2 0 0 2 2 1 1 Ankyrin repeats (many copies) RTP1_C1 PF10363.9 ETO17843.1 - 9.8e-05 22.5 0.7 0.019 15.1 0.2 3.7 2 2 2 4 4 4 1 Required for nuclear transport of RNA pol II C-terminus 1 Ank PF00023.30 ETO17843.1 - 0.00091 19.6 0.0 0.0057 17.1 0.0 2.5 1 0 0 1 1 1 1 Ankyrin repeat SpoU_methylas_C PF12105.8 ETO17843.1 - 0.012 15.3 0.0 0.033 13.9 0.0 1.8 1 0 0 1 1 1 0 SpoU, rRNA methylase, C-terminal NLRC4_HD2 PF17776.1 ETO17843.1 - 0.22 12.1 0.0 0.22 12.1 0.0 6.1 6 0 0 6 6 6 0 NLRC4 helical domain HD2 Actin PF00022.19 ETO17844.1 - 3.8e-104 348.5 0.0 5e-103 344.9 0.0 2.3 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO17844.1 - 0.0043 15.9 0.0 0.3 9.9 0.0 2.3 2 0 0 2 2 2 2 MreB/Mbl protein WD40 PF00400.32 ETO17845.1 - 2e-09 37.9 1.9 0.0012 19.6 0.1 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17845.1 - 0.026 14.8 0.0 1.2 9.4 0.0 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO17845.1 - 0.18 10.8 0.0 0.35 9.8 0.0 1.4 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_M16_C PF05193.21 ETO17846.1 - 0.00042 20.4 2.1 0.0018 18.3 0.1 2.3 2 1 0 2 2 2 1 Peptidase M16 inactive domain zf-C2H2_3rep PF18868.1 ETO17846.1 - 0.052 14.2 0.1 0.1 13.3 0.1 1.6 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats Dcc1 PF09724.9 ETO17847.1 - 6.6e-51 173.6 4.4 1.2e-50 172.7 4.4 1.4 1 1 0 1 1 1 1 Sister chromatid cohesion protein Dcc1 PRIMA1 PF16101.5 ETO17847.1 - 0.88 9.6 3.8 1.7 8.7 3.8 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ABC2_membrane_3 PF12698.7 ETO17850.1 - 0.00024 20.3 2.5 0.00034 19.8 2.5 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein CdvA PF18822.1 ETO17850.1 - 0.011 15.5 4.6 0.011 15.5 4.6 2.8 2 1 0 2 2 2 0 CdvA-like coiled-coil domain SHE3 PF17078.5 ETO17850.1 - 0.46 10.2 33.2 5.5 6.6 15.5 2.4 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 HIP1_clath_bdg PF16515.5 ETO17850.1 - 0.5 11.0 29.6 0.77 10.4 13.5 2.7 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PDCD7 PF16021.5 ETO17850.1 - 0.69 9.0 26.1 0.43 9.7 7.2 2.2 1 1 1 2 2 2 0 Programmed cell death protein 7 DUF641 PF04859.12 ETO17850.1 - 0.76 10.1 20.9 0.26 11.6 4.6 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) NPV_P10 PF05531.12 ETO17850.1 - 0.89 10.1 6.4 0.23 12.0 0.7 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein ERM PF00769.19 ETO17850.1 - 0.91 9.3 36.3 1.5 8.6 36.3 1.4 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Spc29 PF17082.5 ETO17850.1 - 1.7 8.4 23.7 0.2 11.5 3.7 2.5 1 1 1 2 2 2 0 Spindle Pole Component 29 KxDL PF10241.9 ETO17850.1 - 2 8.8 15.4 5.4 7.4 5.4 2.7 2 1 0 2 2 2 0 Uncharacterized conserved protein DUF3450 PF11932.8 ETO17850.1 - 2.5 7.3 25.1 1.1 8.6 7.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Laminin_II PF06009.12 ETO17850.1 - 3.8 7.5 15.3 11 6.1 14.4 2.2 2 1 0 2 2 2 0 Laminin Domain II UPF0242 PF06785.11 ETO17850.1 - 4.7 7.3 39.0 0.15 12.1 15.4 2.5 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ETO17850.1 - 5.7 5.9 25.8 9.3 5.2 25.8 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Swi5 PF07061.11 ETO17850.1 - 6.8 6.9 22.6 1.1 9.4 6.6 3.3 2 2 0 2 2 2 0 Swi5 YabA PF06156.13 ETO17850.1 - 6.8 7.4 25.8 0.19 12.4 7.9 3.0 1 1 1 2 2 2 0 Initiation control protein YabA Phage_GP20 PF06810.11 ETO17850.1 - 7.3 6.4 27.7 7.7 6.3 9.3 2.2 1 1 1 2 2 2 0 Phage minor structural protein GP20 Pox_A_type_inc PF04508.12 ETO17850.1 - 8.3 6.4 8.9 2.8 7.9 1.0 2.9 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat Phlebovirus_NSM PF07246.11 ETO17850.1 - 8.5 5.7 17.3 27 4.0 16.7 2.1 1 1 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF3748 PF12566.8 ETO17851.1 - 0.16 11.9 0.0 0.33 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3748) Pkinase PF00069.25 ETO17852.1 - 8e-28 97.5 0.2 2e-27 96.2 0.2 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17852.1 - 1.8e-12 47.1 0.5 8.4e-07 28.5 0.2 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Mononeg_RNA_pol PF00946.19 ETO17852.1 - 0.0023 15.6 0.8 0.0032 15.2 0.8 1.1 1 0 0 1 1 1 1 Mononegavirales RNA dependent RNA polymerase APH PF01636.23 ETO17852.1 - 0.0052 16.7 0.0 0.008 16.1 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO17852.1 - 0.031 13.9 0.0 0.061 12.9 0.0 1.4 1 0 0 1 1 1 0 RIO1 family Utp14 PF04615.13 ETO17852.1 - 0.079 11.5 16.8 0.11 11.0 16.8 1.2 1 0 0 1 1 1 0 Utp14 protein DUF2457 PF10446.9 ETO17852.1 - 0.38 9.9 17.4 0.6 9.2 17.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO17852.1 - 0.48 8.7 14.9 0.68 8.2 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO17852.1 - 2.2 6.4 18.8 3.1 5.9 18.8 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 ETO17852.1 - 2.8 6.4 11.8 4 5.9 11.8 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO17852.1 - 3.9 5.5 18.7 5.6 4.9 18.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF1848 PF08902.11 ETO17853.1 - 0.028 14.2 2.0 0.08 12.7 2.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1848) Tic110 PF16940.5 ETO17854.1 - 9.2 4.6 8.8 13 4.2 8.8 1.1 1 0 0 1 1 1 0 Chloroplast envelope transporter CDC45 PF02724.14 ETO17855.1 - 2.8e-06 26.0 3.9 3.1e-06 25.8 3.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Presenilin PF01080.17 ETO17855.1 - 0.14 10.9 4.7 0.19 10.5 4.7 1.2 1 0 0 1 1 1 0 Presenilin BNIP2 PF12496.8 ETO17855.1 - 0.26 11.7 5.8 0.39 11.2 5.8 1.3 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 eIF3_subunit PF08597.10 ETO17855.1 - 0.29 11.0 13.9 0.4 10.6 13.9 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Spt5_N PF11942.8 ETO17855.1 - 0.61 11.1 13.6 0.99 10.4 13.6 1.3 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal PUF PF00806.19 ETO17856.1 - 2.8e-42 140.1 4.7 9.9e-08 31.3 0.1 6.3 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat Peptidase_S64 PF08192.11 ETO17856.1 - 7.4e-05 21.5 0.9 9.9e-05 21.0 0.6 1.3 1 1 0 1 1 1 1 Peptidase family S64 Macoilin PF09726.9 ETO17856.1 - 0.0019 16.8 5.0 0.0027 16.4 5.0 1.3 1 0 0 1 1 1 1 Macoilin family JUPITER PF17054.5 ETO17856.1 - 0.0046 16.5 9.3 0.0083 15.6 9.3 1.4 1 0 0 1 1 1 1 Microtubule-Associated protein Jupiter SPX PF03105.19 ETO17856.1 - 0.015 15.2 5.9 0.021 14.8 5.9 1.3 1 0 0 1 1 1 0 SPX domain CPL PF08144.11 ETO17856.1 - 0.017 15.5 2.6 1.3 9.4 0.1 3.3 1 1 2 3 3 3 0 CPL (NUC119) domain CelTOS PF18659.1 ETO17856.1 - 0.055 13.9 0.7 0.66 10.4 0.1 2.5 2 0 0 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites sCache_2 PF17200.4 ETO17856.1 - 0.23 11.3 4.1 6.7 6.6 0.0 3.5 4 0 0 4 4 4 0 Single Cache domain 2 Apt1 PF10351.9 ETO17856.1 - 2.2 7.1 7.2 3 6.6 7.2 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain Activator_LAG-3 PF11498.8 ETO17856.1 - 2.6 6.9 16.0 6.5 5.6 16.0 1.7 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 ETO17856.1 - 3.3 7.6 8.9 0.48 10.4 3.6 2.0 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RAP1 PF07218.11 ETO17856.1 - 6.3 5.0 16.9 8.9 4.4 16.9 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Peptidase_S55 PF05580.12 ETO17857.1 - 0.43 10.5 2.2 6.6 6.6 0.5 2.1 2 0 0 2 2 2 0 SpoIVB peptidase S55 DUF2101 PF09874.9 ETO17858.1 - 0.029 14.1 0.8 0.029 14.1 0.8 1.9 2 1 1 3 3 3 0 Predicted membrane protein (DUF2101) IFT46_B_C PF12317.8 ETO17859.1 - 9.9e-74 247.6 6.5 9.9e-74 247.6 6.5 1.7 2 0 0 2 2 2 1 Intraflagellar transport complex B protein 46 C terminal MatP PF06303.12 ETO17859.1 - 0.017 15.7 0.5 0.068 13.7 0.5 2.0 1 0 0 1 1 1 0 MatP N-terminal domain SMYLE_N PF18615.1 ETO17859.1 - 1.9 8.0 6.2 0.65 9.5 3.6 1.5 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain Ank_4 PF13637.6 ETO17860.1 - 1.8e-18 66.6 1.9 1.7e-05 25.2 0.0 3.9 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO17860.1 - 1.5e-17 63.9 3.9 8.3e-11 42.3 0.9 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO17860.1 - 2.2e-16 58.3 1.8 0.00024 21.3 0.2 4.3 3 1 1 4 4 4 3 Ankyrin repeat Ank PF00023.30 ETO17860.1 - 2.9e-12 46.5 1.2 0.00027 21.2 0.2 3.4 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ETO17860.1 - 6.9e-12 45.4 6.9 3.4e-05 24.0 0.1 3.0 1 1 2 3 3 3 3 Ankyrin repeats (many copies) THP2 PF09432.10 ETO17863.1 - 0.033 14.2 0.2 0.082 13.0 0.2 1.8 1 1 0 1 1 1 0 Tho complex subunit THP2 Myb_DNA-bind_5 PF13873.6 ETO17863.1 - 0.071 13.2 0.8 0.19 11.9 0.8 1.6 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain nsp9 PF08710.10 ETO17864.1 - 0.017 15.5 0.2 0.036 14.5 0.2 1.6 1 0 0 1 1 1 0 nsp9 replicase G-alpha PF00503.20 ETO17866.1 - 3.3e-12 46.2 0.1 4.2e-12 45.9 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit zf-4CXXC_R1 PF10497.9 ETO17867.1 - 0.00084 19.5 23.6 0.086 13.1 23.6 2.2 1 1 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 DUF5472 PF17566.2 ETO17867.1 - 0.099 12.6 4.5 5.9 6.9 0.7 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5472) Spc7 PF08317.11 ETO17868.1 - 7.1e-05 21.8 1.0 0.00013 21.0 1.0 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF812 PF05667.11 ETO17868.1 - 0.00013 21.0 7.0 0.00015 20.8 7.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) CENP-F_leu_zip PF10473.9 ETO17868.1 - 0.00037 20.5 4.9 0.00078 19.5 4.9 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3972 PF13118.6 ETO17868.1 - 0.0036 17.7 3.4 0.0056 17.1 3.4 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3972) KASH_CCD PF14662.6 ETO17868.1 - 0.006 16.4 4.8 0.01 15.7 4.8 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH FapA PF03961.13 ETO17868.1 - 0.0079 14.9 1.8 0.012 14.3 1.8 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A Fez1 PF06818.15 ETO17868.1 - 0.02 15.4 3.8 0.02 15.4 3.8 2.1 2 0 0 2 2 2 0 Fez1 Macoilin PF09726.9 ETO17868.1 - 0.023 13.3 10.6 0.028 13.0 10.6 1.0 1 0 0 1 1 1 0 Macoilin family FAM76 PF16046.5 ETO17868.1 - 0.027 13.8 11.9 0.039 13.3 11.9 1.1 1 0 0 1 1 1 0 FAM76 protein Cep57_MT_bd PF06657.13 ETO17868.1 - 0.15 12.5 4.0 0.81 10.2 1.0 2.3 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 YabA PF06156.13 ETO17868.1 - 0.35 11.5 4.4 0.11 13.2 1.1 1.9 2 0 0 2 2 2 0 Initiation control protein YabA Prefoldin PF02996.17 ETO17868.1 - 0.37 10.7 6.7 0.61 10.0 4.5 2.1 2 0 0 2 2 2 0 Prefoldin subunit VPS38 PF17649.1 ETO17868.1 - 0.58 9.0 10.1 0.014 14.3 3.8 1.4 2 0 0 2 2 2 0 Vacuolar protein sorting 38 DUF4472 PF14739.6 ETO17868.1 - 0.66 10.7 11.4 0.05 14.3 5.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4472) Atg14 PF10186.9 ETO17868.1 - 0.96 8.5 15.0 0.043 12.9 8.9 1.6 1 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF724 PF05266.14 ETO17868.1 - 1.3 8.8 9.3 0.042 13.7 2.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Lzipper-MIP1 PF14389.6 ETO17868.1 - 2.2 8.6 8.1 1 9.7 3.6 2.2 1 1 1 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 Lebercilin PF15619.6 ETO17868.1 - 2.6 7.7 16.3 0.22 11.1 9.2 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease APG6_N PF17675.1 ETO17868.1 - 7.9 7.0 14.9 25 5.4 14.9 2.0 1 1 0 1 1 1 0 Apg6 coiled-coil region Ribosomal_L6 PF00347.23 ETO17872.1 - 0.064 13.9 0.1 0.45 11.2 0.1 2.3 2 0 0 2 2 2 0 Ribosomal protein L6 SIS PF01380.22 ETO17874.1 - 2.5e-27 95.3 1.7 4.6e-15 55.6 0.3 2.2 2 0 0 2 2 2 2 SIS domain GATase_7 PF13537.6 ETO17875.1 - 3.9e-06 26.8 0.0 9.7e-06 25.5 0.0 1.6 2 0 0 2 2 2 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ETO17875.1 - 0.0034 17.6 0.0 0.0047 17.1 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase domain Duffy_binding PF05424.11 ETO17876.1 - 0.05 13.7 0.3 0.05 13.7 0.3 1.7 2 0 0 2 2 2 0 Duffy binding domain DUF1189 PF06691.11 ETO17877.1 - 0.012 15.2 0.5 0.015 14.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) DUF4293 PF14126.6 ETO17877.1 - 1.1 9.5 3.3 1.7 8.9 3.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4293) FF PF01846.19 ETO17878.1 - 6.3e-05 23.1 0.1 0.00014 22.0 0.1 1.6 1 0 0 1 1 1 1 FF domain PriA_C PF18074.1 ETO17878.1 - 0.095 13.5 1.2 0.13 13.1 1.2 1.2 1 0 0 1 1 1 0 Primosomal protein N C-terminal domain ATP-synt_E PF05680.12 ETO17878.1 - 0.47 10.8 5.6 0.29 11.5 2.6 1.8 2 0 0 2 2 2 0 ATP synthase E chain WGR PF05406.15 ETO17878.1 - 0.5 10.5 5.6 0.81 9.8 0.1 2.2 2 0 0 2 2 2 0 WGR domain DUF604 PF04646.12 ETO17880.1 - 0.11 11.9 0.1 0.11 11.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function, DUF604 Mucin PF01456.17 ETO17880.1 - 0.11 12.4 0.8 0.18 11.8 0.8 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FAM176 PF14851.6 ETO17880.1 - 0.11 12.1 4.9 0.058 13.0 1.3 1.9 2 0 0 2 2 2 0 FAM176 family TIMELESS_C PF05029.13 ETO17880.1 - 3.6 6.6 15.6 1.5 7.9 5.6 3.0 2 1 1 3 3 3 0 Timeless protein C terminal region EF-hand_6 PF13405.6 ETO17881.1 - 0.03 14.3 0.0 0.07 13.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 ETO17881.1 - 0.031 13.8 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 ETO17881.1 - 0.069 13.6 0.1 0.22 12.0 0.1 1.8 1 0 0 1 1 1 0 EF-hand domain pair DUF680 PF05079.12 ETO17882.1 - 0.044 14.5 0.3 0.044 14.5 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF680) uDENN PF03456.18 ETO17884.1 - 8e-15 55.3 1.3 1.6e-14 54.4 1.3 1.5 1 0 0 1 1 1 1 uDENN domain OrfB_IS605 PF01385.19 ETO17884.1 - 0.2 11.9 0.6 0.26 11.5 0.6 1.2 1 0 0 1 1 1 0 Probable transposase Dicty_REP PF05086.12 ETO17884.1 - 2.5 6.0 5.3 2.7 5.8 5.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 ETO17884.1 - 4.5 7.3 17.9 5.5 7.0 17.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 ETO17884.1 - 5.7 4.9 12.9 4.7 5.2 11.5 1.5 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus Ank_2 PF12796.7 ETO17885.1 - 5.6e-09 36.5 1.0 0.039 14.5 0.1 3.7 2 1 2 4 4 4 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO17885.1 - 8.4e-06 26.0 0.0 0.055 13.8 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO17885.1 - 3.3e-05 23.9 0.0 21 6.1 0.0 5.5 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 ETO17885.1 - 0.00016 22.2 0.1 0.89 10.2 0.0 4.3 5 0 0 5 5 5 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO17885.1 - 0.0014 18.9 0.1 0.53 10.8 0.0 3.5 4 0 0 4 4 4 1 Ankyrin repeat Herpes_UL82_83 PF05784.11 ETO17885.1 - 0.029 13.2 0.7 0.048 12.5 0.7 1.3 1 0 0 1 1 1 0 Betaherpesvirus UL82/83 protein N terminus ArfA PF03889.13 ETO17886.1 - 0.057 12.9 0.2 0.11 12.0 0.2 1.4 1 0 0 1 1 1 0 Alternative ribosome-rescue factor A DUF4659 PF15558.6 ETO17886.1 - 0.96 8.3 15.5 1.4 7.8 15.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4659) DUF1764 PF08576.10 ETO17886.1 - 1.1 10.2 0.1 1.1 10.2 0.1 2.8 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF1764) Rootletin PF15035.6 ETO17887.1 - 2.1e-06 27.9 17.2 2.1e-06 27.9 17.2 2.6 1 1 1 2 2 2 1 Ciliary rootlet component, centrosome cohesion TMF_TATA_bd PF12325.8 ETO17887.1 - 0.00024 21.3 37.5 0.012 15.8 4.9 3.4 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding YabA PF06156.13 ETO17887.1 - 0.00044 20.8 12.8 0.00044 20.8 12.8 3.4 1 1 2 3 3 3 1 Initiation control protein YabA APG6_N PF17675.1 ETO17887.1 - 0.02 15.4 48.9 2.2 8.8 22.6 3.3 1 1 2 3 3 3 0 Apg6 coiled-coil region ATG16 PF08614.11 ETO17887.1 - 0.04 14.1 40.8 0.43 10.8 22.9 2.7 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) GAS PF13851.6 ETO17887.1 - 0.16 11.3 45.1 0.19 11.1 18.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 ETO17887.1 - 0.17 12.3 36.1 0.44 11.0 15.7 2.1 1 1 1 2 2 2 0 Fez1 PI3K_P85_iSH2 PF16454.5 ETO17887.1 - 0.24 11.0 36.1 0.24 11.0 13.2 2.8 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain HAP1_N PF04849.13 ETO17887.1 - 0.66 9.1 43.6 4.3 6.5 13.7 3.6 1 1 2 3 3 3 0 HAP1 N-terminal conserved region Spc7 PF08317.11 ETO17887.1 - 4.4 6.1 40.0 0.86 8.4 24.3 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein bZIP_1 PF00170.21 ETO17887.1 - 4.6 7.4 35.3 0.25 11.5 8.5 4.9 3 2 3 6 6 6 0 bZIP transcription factor TMF_DNA_bd PF12329.8 ETO17887.1 - 5.2 7.1 38.0 1.1 9.3 13.7 3.4 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding DegS PF05384.11 ETO17887.1 - 6.9 6.1 31.2 0.52 9.8 12.4 3.1 1 1 0 2 2 2 0 Sensor protein DegS Alph_Pro_TM PF09608.10 ETO17887.1 - 7.3 6.3 7.1 3.1 7.5 0.4 2.4 1 1 0 2 2 2 0 Putative transmembrane protein (Alph_Pro_TM) BRE1 PF08647.11 ETO17887.1 - 7.4 6.7 37.3 0.5 10.5 14.6 3.0 2 2 0 2 2 2 0 BRE1 E3 ubiquitin ligase YlqD PF11068.8 ETO17887.1 - 9.1 6.7 43.5 9 6.7 18.7 2.7 1 1 2 3 3 3 0 YlqD protein CitMHS PF03600.16 ETO17891.1 - 0.13 11.4 2.5 0.16 11.1 2.5 1.2 1 0 0 1 1 1 0 Citrate transporter DUF1077 PF06417.12 ETO17891.1 - 1.8 8.6 9.9 1.9 8.5 2.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1077) FKBP_C PF00254.28 ETO17893.1 - 8e-13 48.5 0.0 1.8e-12 47.4 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase EphA2_TM PF14575.6 ETO17894.1 - 0.0036 18.2 0.2 0.64 10.9 0.1 2.4 2 0 0 2 2 2 1 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 ETO17894.1 - 0.0062 16.8 0.0 0.013 15.8 0.0 1.5 1 1 0 1 1 1 1 Wnt and FGF inhibitory regulator MAP17 PF15807.5 ETO17894.1 - 0.0069 16.6 0.4 0.28 11.4 0.0 2.2 2 0 0 2 2 2 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Orthoreo_P10 PF07204.11 ETO17894.1 - 0.009 15.9 1.7 0.01 15.8 0.9 1.6 1 1 0 1 1 1 1 Orthoreovirus membrane fusion protein p10 Wzy_C PF04932.15 ETO17894.1 - 0.082 12.5 0.2 0.18 11.5 0.1 1.5 1 1 0 1 1 1 0 O-Antigen ligase DUF4330 PF14221.6 ETO17894.1 - 0.088 13.0 2.6 0.049 13.9 0.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4330) TMEM51 PF15345.6 ETO17894.1 - 0.11 12.3 2.9 0.35 10.7 2.1 1.8 1 1 1 2 2 2 0 Transmembrane protein 51 TMEM100 PF16311.5 ETO17894.1 - 2.1 7.9 9.8 2.2 7.9 1.6 3.0 2 1 1 3 3 3 0 Transmembrane protein 100 TMEM154 PF15102.6 ETO17894.1 - 5 7.0 0.0 5 7.0 0.0 3.1 2 1 1 3 3 3 0 TMEM154 protein family V-ATPase_H_N PF03224.14 ETO17895.1 - 3.5e-09 36.4 0.0 5e-09 35.9 0.0 1.2 1 0 0 1 1 1 1 V-ATPase subunit H zf-C2H2 PF00096.26 ETO17897.1 - 5.3e-06 26.6 24.1 0.013 15.9 2.1 3.9 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO17897.1 - 0.0012 19.2 0.1 0.0012 19.2 0.1 4.1 4 0 0 4 4 4 1 Zinc-finger double domain zf-met PF12874.7 ETO17897.1 - 0.018 15.4 0.6 0.018 15.4 0.6 3.6 3 0 0 3 3 3 0 Zinc-finger of C2H2 type zf-C2H2_4 PF13894.6 ETO17897.1 - 0.022 15.6 22.0 1.9 9.6 1.6 3.9 3 0 0 3 3 3 0 C2H2-type zinc finger zf_C2H2_ZHX PF18387.1 ETO17897.1 - 0.12 12.1 0.3 0.12 12.1 0.3 2.5 2 0 0 2 2 2 0 Zinc-fingers and homeoboxes C2H2 finger domain FYVE PF01363.21 ETO17897.1 - 0.2 11.8 5.7 0.57 10.4 5.7 1.8 1 0 0 1 1 1 0 FYVE zinc finger zf-C2H2_8 PF15909.5 ETO17897.1 - 0.62 10.4 10.5 4.6 7.6 3.6 2.6 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_2 PF12756.7 ETO17897.1 - 4.6 7.6 14.1 20 5.6 13.7 2.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) DUF21 PF01595.20 ETO17898.1 - 1.4 8.6 11.2 0.13 12.0 5.4 2.3 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain F-box-like PF12937.7 ETO17899.1 - 8.3e-07 28.8 0.7 8.3e-07 28.8 0.7 1.6 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ETO17899.1 - 0.00011 21.9 1.9 0.00039 20.2 1.9 1.9 1 1 0 1 1 1 1 F-box domain AIF_C PF14721.6 ETO17899.1 - 0.22 11.9 2.5 0.35 11.2 0.2 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term RR_TM4-6 PF06459.12 ETO17899.1 - 1.3 8.8 12.9 0.25 11.1 7.4 1.9 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Autophagy_N PF03986.13 ETO17899.1 - 2.7 7.9 10.3 0.64 10.0 6.0 1.9 2 0 0 2 2 2 0 Autophagocytosis associated protein (Atg3), N-terminal domain PVL_ORF50 PF07768.11 ETO17899.1 - 7.5 6.9 19.1 0.63 10.4 13.1 1.9 2 0 0 2 2 2 0 PVL ORF-50-like family Ank_2 PF12796.7 ETO17900.1 - 0.00021 21.8 0.0 0.00045 20.7 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) GGDEF PF00990.21 ETO17900.1 - 0.029 14.1 0.0 0.33 10.7 0.0 2.2 1 1 0 1 1 1 0 Diguanylate cyclase, GGDEF domain Phage_min_tail PF05939.13 ETO17900.1 - 0.046 14.1 0.1 0.14 12.5 0.1 1.8 1 1 1 2 2 2 0 Phage minor tail protein GAPT PF11770.8 ETO17901.1 - 0.042 13.7 0.1 0.075 12.9 0.0 1.4 2 0 0 2 2 2 0 GRB2-binding adapter (GAPT) BTV_NS2 PF04514.12 ETO17901.1 - 0.16 10.8 0.0 0.19 10.5 0.0 1.1 1 0 0 1 1 1 0 Bluetongue virus non-structural protein NS2 SAPS PF04499.15 ETO17903.1 - 0.25 10.1 11.1 0.38 9.5 11.1 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nucleoside_tran PF01733.18 ETO17903.1 - 1.9 7.8 5.5 1 8.7 0.1 2.0 2 0 0 2 2 2 0 Nucleoside transporter RR_TM4-6 PF06459.12 ETO17903.1 - 2.7 7.8 16.4 0.63 9.8 7.4 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 PPL5 PF18168.1 ETO17903.1 - 6.7 5.9 13.1 8.9 5.5 5.8 2.1 2 0 0 2 2 2 0 Prim-pol family 5 CPSF100_C PF13299.6 ETO17903.1 - 9 6.4 14.2 17 5.5 0.7 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Chromo PF00385.24 ETO17905.1 - 2e-05 24.4 2.1 5e-05 23.1 2.1 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain TFIIF_alpha PF05793.12 ETO17905.1 - 0.0013 17.5 8.8 0.0015 17.2 8.8 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Rubredoxin PF00301.20 ETO17905.1 - 0.0066 16.5 1.9 0.25 11.4 0.1 2.8 2 0 0 2 2 2 1 Rubredoxin PHD PF00628.29 ETO17905.1 - 0.1 12.5 6.1 4.5 7.2 0.2 2.7 2 0 0 2 2 2 0 PHD-finger RNA_pol_3_Rpc31 PF11705.8 ETO17905.1 - 0.14 12.4 10.6 0.31 11.3 10.6 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Enterotoxin_ST PF02048.16 ETO17905.1 - 0.14 12.6 1.5 0.49 10.9 1.5 1.9 1 0 0 1 1 1 0 Heat-stable enterotoxin ST NOA36 PF06524.12 ETO17905.1 - 0.16 11.3 10.4 0.24 10.7 10.4 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETO17905.1 - 0.16 11.6 11.0 0.27 10.8 11.0 1.3 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 ETO17905.1 - 1.7 6.7 11.9 2.2 6.4 11.9 1.1 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 ETO17905.1 - 2.9 6.8 13.9 0.74 8.7 9.5 1.9 2 0 0 2 2 2 0 Paf1 DNA_pol_phi PF04931.13 ETO17905.1 - 3.8 5.5 19.7 6.1 4.8 19.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi FYDLN_acid PF09538.10 ETO17905.1 - 4.9 7.9 17.1 0.9 10.3 12.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF2457 PF10446.9 ETO17905.1 - 9.1 5.3 18.0 13 4.8 18.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SET PF00856.28 ETO17906.1 - 0.00012 22.6 0.0 0.0048 17.3 0.0 2.1 2 0 0 2 2 2 2 SET domain DUF1491 PF07372.12 ETO17906.1 - 0.022 15.1 0.2 0.034 14.5 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) Shugoshin_N PF07558.11 ETO17908.1 - 0.13 12.2 6.6 0.26 11.2 0.7 3.1 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region Cnn_1N PF07989.11 ETO17908.1 - 3.4 7.9 8.3 1.9e+02 2.3 8.3 3.1 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 TMF_DNA_bd PF12329.8 ETO17908.1 - 5.5 7.1 10.0 34 4.5 4.6 3.2 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding CLASP_N PF12348.8 ETO17909.1 - 7e-10 38.9 3.3 1e-09 38.3 3.3 1.1 1 0 0 1 1 1 1 CLASP N terminal Vac14_Fab1_bd PF12755.7 ETO17909.1 - 0.019 15.6 1.4 0.84 10.3 0.1 3.0 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region Coat_F PF07875.12 ETO17909.1 - 0.072 13.3 1.1 3.7 7.9 0.1 3.1 3 0 0 3 3 3 0 Coat F domain SIL1 PF16782.5 ETO17909.1 - 0.17 11.1 6.6 0.25 10.5 5.4 1.8 2 1 0 2 2 2 0 Nucleotide exchange factor SIL1 DUF1981 PF09324.10 ETO17909.1 - 0.45 10.4 5.9 0.74 9.7 0.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1981) TMEM132D_C PF15706.5 ETO17909.1 - 1.8 8.4 4.9 1.4 8.7 0.7 2.6 3 0 0 3 3 3 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term IMD PF08397.11 ETO17910.1 - 0.35 10.2 5.0 6.6 6.0 4.9 2.1 1 1 0 1 1 1 0 IRSp53/MIM homology domain ALMT PF11744.8 ETO17911.1 - 0.74 8.6 6.2 1 8.1 6.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DNA_binding_1 PF01035.20 ETO17912.1 - 2.6e-22 78.8 0.0 4.2e-22 78.1 0.0 1.3 1 0 0 1 1 1 1 6-O-methylguanine DNA methyltransferase, DNA binding domain DUF2815 PF10991.8 ETO17912.1 - 0.056 13.4 0.5 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2815) Sel1 PF08238.12 ETO17913.1 - 0.00019 22.0 10.4 0.12 13.2 0.2 5.1 5 0 0 5 5 5 2 Sel1 repeat DUF4976 PF16347.5 ETO17914.1 - 1.8e-06 28.1 0.2 2.9e-06 27.5 0.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4976) Sulfatase PF00884.23 ETO17914.1 - 0.0012 18.3 0.1 0.026 13.9 0.0 2.1 2 0 0 2 2 2 1 Sulfatase DUF4994 PF16385.5 ETO17914.1 - 0.089 12.7 0.6 1.1 9.2 0.6 2.3 1 1 0 1 1 1 0 Domain of unknown function Sulfatase_C PF14707.6 ETO17914.1 - 0.14 12.9 0.0 0.22 12.3 0.0 1.3 1 0 0 1 1 1 0 C-terminal region of aryl-sulfatase Kelch_2 PF07646.15 ETO17916.1 - 0.14 12.2 0.8 1.1 9.4 0.2 2.8 3 0 0 3 3 3 0 Kelch motif GLTSCR1 PF15249.6 ETO17917.1 - 0.74 10.3 4.5 0.2 12.1 0.9 1.9 2 0 0 2 2 2 0 Conserved region of unknown function on GLTSCR protein Gly-zipper_Omp PF13488.6 ETO17918.1 - 4.3e-08 33.0 31.2 0.23 11.5 2.2 3.9 1 1 1 2 2 2 1 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO17918.1 - 6.8e-06 25.7 23.2 0.011 15.4 1.8 4.0 3 2 0 3 3 3 2 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 ETO17918.1 - 0.055 13.3 37.7 2.1 8.3 16.5 5.1 2 1 2 4 4 4 0 Glycine zipper 2TM domain MscL PF01741.18 ETO17918.1 - 0.46 10.8 10.7 3.8 7.8 3.0 2.7 1 1 1 2 2 2 0 Large-conductance mechanosensitive channel, MscL MccV PF17508.2 ETO17918.1 - 0.56 10.8 9.9 1.1 9.9 3.7 2.6 1 1 1 2 2 2 0 Microcin V bacteriocin TraT PF05818.12 ETO17918.1 - 0.89 9.2 11.8 2 8.0 1.2 2.4 1 1 1 2 2 2 0 Enterobacterial TraT complement resistance protein Gly-zipper_OmpA PF13436.6 ETO17918.1 - 2.4 8.0 24.5 0.23 11.3 1.3 3.5 3 1 0 3 3 3 0 Glycine-zipper domain Bacteriocin_IIc PF10439.9 ETO17918.1 - 3 8.0 31.9 8.2 6.6 6.3 3.2 1 1 1 2 2 2 0 Bacteriocin class II with double-glycine leader peptide DEAD PF00270.29 ETO17919.1 - 5.4e-08 32.8 0.0 6.3e-08 32.6 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase UvrD-helicase PF00580.21 ETO17919.1 - 0.0012 18.5 0.0 0.0013 18.3 0.0 1.1 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_29 PF13555.6 ETO17919.1 - 0.0033 17.1 0.0 0.005 16.5 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_19 PF13245.6 ETO17919.1 - 0.0096 16.3 0.0 0.013 15.8 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 ETO17919.1 - 0.01 15.3 0.0 0.014 14.8 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_30 PF13604.6 ETO17919.1 - 0.017 14.8 0.0 0.023 14.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO17919.1 - 0.025 15.1 0.0 0.041 14.4 0.0 1.4 1 0 0 1 1 1 0 ABC transporter ResIII PF04851.15 ETO17919.1 - 0.049 13.6 0.0 0.07 13.1 0.0 1.2 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit Terminase_GpA PF05876.12 ETO17919.1 - 0.051 12.1 0.0 0.066 11.8 0.0 1.1 1 0 0 1 1 1 0 Phage terminase large subunit (GpA) AAA_16 PF13191.6 ETO17919.1 - 0.056 13.8 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain ATP-synt_ab PF00006.25 ETO17919.1 - 0.16 11.6 0.0 0.22 11.2 0.0 1.1 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain DnaJ PF00226.31 ETO17921.1 - 2.1e-09 37.3 2.9 2.1e-09 37.3 2.9 2.6 2 2 0 2 2 2 1 DnaJ domain TPR_1 PF00515.28 ETO17921.1 - 2.8e-09 36.4 10.2 2.2e-05 24.1 0.7 3.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17921.1 - 2.9e-09 36.5 1.2 0.0086 15.7 0.0 3.3 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.17 ETO17921.1 - 1.5e-08 34.1 6.9 8.4e-06 25.5 1.2 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17921.1 - 2e-07 31.5 0.2 0.002 18.7 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17921.1 - 7.2e-05 22.9 2.0 0.00028 21.1 0.1 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17921.1 - 0.00028 20.9 4.8 0.026 14.7 0.1 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO17921.1 - 0.00042 20.9 3.5 0.086 13.7 0.2 3.7 2 1 2 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17921.1 - 0.00058 20.3 2.4 0.032 14.8 0.2 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO17921.1 - 0.0012 19.1 7.1 0.0098 16.2 0.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17921.1 - 0.046 13.7 1.8 0.72 10.0 0.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO17921.1 - 0.051 13.7 0.7 0.15 12.3 0.2 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat ST7 PF04184.12 ETO17921.1 - 0.45 8.9 4.8 0.53 8.7 4.8 1.1 1 0 0 1 1 1 0 ST7 protein TPR_10 PF13374.6 ETO17921.1 - 0.53 10.2 4.6 5.7 7.0 0.6 3.3 3 1 0 3 3 2 0 Tetratricopeptide repeat DicB PF05358.11 ETO17921.1 - 1.1 9.4 2.7 13 6.0 0.2 3.1 3 0 0 3 3 3 0 DicB protein HECT PF00632.25 ETO17922.1 - 1.8e-85 287.2 0.0 3.8e-85 286.1 0.0 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TMCO5 PF14992.6 ETO17923.1 - 0.057 13.0 0.0 0.08 12.5 0.0 1.1 1 0 0 1 1 1 0 TMCO5 family DUF3402 PF11882.8 ETO17924.1 - 0.012 14.7 1.3 0.012 14.8 1.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) MID_MedPIWI PF18296.1 ETO17924.1 - 0.043 13.6 5.7 0.052 13.3 5.7 1.1 1 0 0 1 1 1 0 MID domain of medPIWI CENP-B_dimeris PF09026.10 ETO17924.1 - 0.12 12.7 6.1 0.23 11.9 6.1 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ETO17924.1 - 0.58 9.2 7.8 0.82 8.7 7.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 ETO17924.1 - 0.68 9.2 10.4 1.1 8.6 10.4 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2076 PF09849.9 ETO17924.1 - 0.92 9.5 13.0 0.99 9.4 13.0 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Presenilin PF01080.17 ETO17924.1 - 4.1 6.1 5.4 4.2 6.0 5.4 1.1 1 0 0 1 1 1 0 Presenilin TFIIE-A_C PF11521.8 ETO17924.1 - 4.6 7.6 7.6 4.5 7.7 5.5 1.9 2 0 0 2 2 2 0 C-terminal general transcription factor TFIIE alpha Cwf_Cwc_15 PF04889.12 ETO17924.1 - 4.7 6.9 16.3 5.9 6.5 16.3 1.3 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BicD PF09730.9 ETO17925.1 - 0.065 11.7 1.2 0.075 11.4 1.2 1.0 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D SMN PF06003.12 ETO17926.1 - 4.5 6.5 7.0 3.1 7.0 5.7 1.4 1 1 0 1 1 1 0 Survival motor neuron protein (SMN) GARP PF16731.5 ETO17928.1 - 0.057 13.1 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma Ribosomal_L18A PF01775.17 ETO17929.1 - 0.0017 18.5 0.3 0.0067 16.5 0.1 2.1 2 0 0 2 2 2 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A DUF3439 PF11921.8 ETO17929.1 - 0.16 12.0 0.6 0.44 10.5 0.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) UCH PF00443.29 ETO17930.1 - 0.012 15.1 1.1 0.014 14.9 1.1 1.1 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase DNA_pol_A_exo1 PF01612.20 ETO17931.1 - 0.037 13.7 5.8 0.15 11.8 0.4 3.2 2 1 1 3 3 3 0 3'-5' exonuclease DUF553 PF04473.12 ETO17931.1 - 0.049 13.1 1.5 1.6 8.3 0.3 3.1 1 1 1 2 2 2 0 Transglutaminase-like domain fn3 PF00041.21 ETO17932.1 - 9.8e-05 22.6 1.4 0.048 14.0 1.4 2.4 1 1 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ETO17932.1 - 0.014 16.0 6.2 0.063 13.9 6.2 1.9 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain DUF913 PF06025.12 ETO17932.1 - 0.12 11.3 7.0 0.14 11.1 7.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.12 ETO17932.1 - 0.46 8.6 20.0 0.46 8.6 20.0 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 ETO17932.1 - 0.81 8.2 14.0 0.9 8.0 14.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETO17932.1 - 1.1 7.5 17.8 1.1 7.4 17.8 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ETO17932.1 - 6.6 6.0 21.2 9.5 5.4 21.2 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO17932.1 - 9.8 4.1 20.4 11 3.9 20.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi eIF-3_zeta PF05091.12 ETO17933.1 - 4.4e-09 35.9 0.7 5.1e-09 35.6 0.7 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CAC1F_C PF16885.5 ETO17934.1 - 0.25 10.9 11.7 0.32 10.6 11.7 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Merozoite_SPAM PF07133.11 ETO17934.1 - 0.38 10.7 21.2 0.82 9.6 21.2 1.7 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 ETO17934.1 - 0.45 8.7 11.7 0.54 8.5 11.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Casc1_N PF15927.5 ETO17934.1 - 0.62 9.7 19.6 1.6 8.3 16.8 2.2 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 N-terminus GOLD_2 PF13897.6 ETO17934.1 - 4.5 7.8 7.0 1.5 9.3 4.1 1.8 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking GREB1 PF15782.5 ETO17934.1 - 4.5 4.3 14.4 5 4.1 14.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer HECT_2 PF09814.9 ETO17935.1 - 0.00011 21.2 0.2 0.00014 20.9 0.2 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding DUF4834 PF16118.5 ETO17935.1 - 0.0037 18.2 0.7 0.0068 17.3 0.7 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) EphA2_TM PF14575.6 ETO17935.1 - 0.0061 17.4 0.2 0.014 16.2 0.2 1.8 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Baculo_11_kDa PF06143.11 ETO17935.1 - 0.024 14.2 5.9 0.067 12.8 5.9 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF4446 PF14584.6 ETO17935.1 - 0.1 12.6 3.8 0.26 11.2 3.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) ABC2_membrane_3 PF12698.7 ETO17935.1 - 0.16 11.1 5.1 0.48 9.5 1.9 2.2 2 0 0 2 2 2 0 ABC-2 family transporter protein Sigma_reg_N PF13800.6 ETO17935.1 - 0.23 11.7 8.0 0.11 12.8 4.4 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal TMEM154 PF15102.6 ETO17935.1 - 0.6 10.0 7.3 1.5 8.8 7.3 1.7 1 0 0 1 1 1 0 TMEM154 protein family DUF2615 PF11027.8 ETO17935.1 - 1 9.5 3.5 0.39 10.9 0.4 1.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2615) Tmemb_9 PF05434.11 ETO17935.1 - 1.4 8.8 9.3 1 9.3 7.7 1.6 1 1 0 1 1 1 0 TMEM9 ABC2_membrane_3 PF12698.7 ETO17937.1 - 1.4e-29 103.3 27.6 1.4e-29 103.3 27.6 1.8 2 0 0 2 2 2 1 ABC-2 family transporter protein WD40 PF00400.32 ETO17941.1 - 8.9e-39 130.8 10.8 1.5e-09 38.3 0.4 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO17941.1 - 1.6e-13 50.8 0.1 0.011 16.0 0.0 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO17941.1 - 6.6e-08 32.7 0.0 5.1e-07 29.8 0.0 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO17941.1 - 1.7e-06 27.3 0.1 0.32 9.9 0.0 3.8 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO17941.1 - 0.00015 21.2 0.0 0.23 10.7 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO17941.1 - 0.0028 16.4 0.3 0.37 9.4 0.0 3.3 1 1 2 3 3 3 1 Nucleoporin Nup120/160 SAM35 PF10806.8 ETO17941.1 - 0.025 14.9 1.2 0.04 14.2 1.2 1.3 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex DUF5046 PF16465.5 ETO17941.1 - 0.057 12.9 0.0 0.26 10.7 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) DUF4384 PF14326.6 ETO17941.1 - 0.063 13.4 0.0 0.27 11.4 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4384) PQQ PF01011.21 ETO17941.1 - 0.09 12.7 0.0 0.41 10.7 0.0 2.2 1 0 0 1 1 1 0 PQQ enzyme repeat nos_propeller PF18764.1 ETO17941.1 - 0.091 12.7 0.0 1.7 8.6 0.0 2.6 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat B3_4 PF03483.17 ETO17941.1 - 0.12 12.1 0.0 0.62 9.7 0.0 2.2 2 1 1 3 3 3 0 B3/4 domain DUF2140 PF09911.9 ETO17942.1 - 0.0093 15.5 0.2 0.01 15.4 0.2 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2140) EF-hand_1 PF00036.32 ETO17943.1 - 3.8e-24 82.4 5.7 5.4e-08 31.8 0.1 5.0 4 1 0 5 5 5 3 EF hand EF-hand_7 PF13499.6 ETO17943.1 - 2.9e-21 75.7 3.5 1e-11 45.1 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO17943.1 - 4.5e-18 63.9 9.2 1.4e-05 24.4 0.1 4.8 5 1 1 6 6 6 3 EF hand EF-hand_8 PF13833.6 ETO17943.1 - 5.8e-18 64.5 6.1 7.1e-07 29.0 0.1 4.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO17943.1 - 6.5e-18 63.1 6.1 1.6e-05 24.4 0.0 5.8 4 1 2 6 6 6 3 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO17943.1 - 7.2e-07 29.5 0.0 0.00081 19.7 0.0 2.4 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETO17943.1 - 2.4e-05 24.5 0.1 0.0036 17.6 0.0 2.6 2 0 0 2 2 2 1 EF-hand domain Dockerin_1 PF00404.18 ETO17943.1 - 0.00054 20.1 1.2 0.17 12.1 0.8 2.7 2 1 0 2 2 2 1 Dockerin type I domain EF-hand_4 PF12763.7 ETO17943.1 - 0.0042 17.0 0.1 0.12 12.3 0.0 2.2 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Pex14_N PF04695.13 ETO17943.1 - 0.014 16.1 7.7 1.4 9.6 6.5 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region REGB_T4 PF10715.9 ETO17943.1 - 0.087 13.0 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 T4-page Endoribonuclease RegB DUF3349 PF11829.8 ETO17943.1 - 0.1 13.4 0.4 11 6.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3349) Leucyl-specific PF14795.6 ETO17943.1 - 0.11 12.6 1.6 4.6 7.4 0.0 3.2 3 1 1 4 4 4 0 Leucine-tRNA synthetase-specific domain EF-hand_10 PF14788.6 ETO17943.1 - 0.12 12.3 0.3 14 5.7 0.0 3.2 3 1 0 3 3 3 0 EF hand Excalibur PF05901.11 ETO17943.1 - 0.16 12.6 0.3 25 5.6 0.1 2.7 3 0 0 3 3 3 0 Excalibur calcium-binding domain Skp1 PF01466.19 ETO17943.1 - 3.2 7.9 4.9 5.2 7.3 1.2 2.7 2 1 1 3 3 3 0 Skp1 family, dimerisation domain Mg_chelatase PF01078.21 ETO17945.1 - 2.9e-79 265.3 0.0 3.5e-79 265.0 0.0 1.1 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETO17945.1 - 1.2e-10 41.5 0.0 1.9e-09 37.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) MCM PF00493.23 ETO17945.1 - 7.1e-10 38.3 0.0 2.3e-09 36.7 0.0 2.0 1 1 0 1 1 1 1 MCM P-loop domain Sigma54_activat PF00158.26 ETO17945.1 - 7e-07 29.1 0.0 1.9e-05 24.4 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain Mg_chelatase_C PF13335.6 ETO17945.1 - 2.2e-06 28.2 0.0 3.8e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI C-terminal AAA PF00004.29 ETO17945.1 - 0.00095 19.6 0.0 0.011 16.2 0.0 2.5 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO17945.1 - 0.0023 18.2 0.0 0.047 14.0 0.0 2.5 3 0 0 3 3 3 1 AAA domain AAA_2 PF07724.14 ETO17945.1 - 0.0053 16.9 0.0 0.029 14.5 0.0 2.1 2 1 0 2 2 2 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ETO17945.1 - 0.0058 16.8 0.0 0.011 15.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain DRY_EERY PF09750.9 ETO17945.1 - 0.0069 16.7 0.0 0.0094 16.2 0.0 1.2 1 0 0 1 1 1 1 Alternative splicing regulator RuvB_N PF05496.12 ETO17945.1 - 0.066 13.0 0.0 6.1 6.6 0.0 3.0 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 ETO17945.1 - 0.14 12.6 0.0 0.52 10.8 0.0 2.1 1 1 0 1 1 1 0 ABC transporter DciA PF05258.12 ETO17946.1 - 4e-13 49.6 0.0 1.2e-12 48.0 0.0 1.7 2 0 0 2 2 2 1 Dna[CI] antecedent, DciA Apis_Csd PF11671.8 ETO17947.1 - 0.13 12.3 6.4 0.23 11.5 6.4 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein ATP11 PF06644.11 ETO17947.1 - 0.28 10.9 2.7 0.42 10.4 2.7 1.2 1 0 0 1 1 1 0 ATP11 protein DUF2967 PF11179.8 ETO17947.1 - 0.3 9.1 13.8 0.39 8.8 13.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) PI3K_1B_p101 PF10486.9 ETO17947.1 - 0.33 8.7 4.8 0.41 8.4 4.8 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Macoilin PF09726.9 ETO17947.1 - 2.5 6.6 9.9 3.1 6.2 9.9 1.1 1 0 0 1 1 1 0 Macoilin family Secretin_N_2 PF07655.13 ETO17947.1 - 3.7 8.2 20.0 4.1 8.0 18.7 1.7 1 1 0 1 1 1 0 Secretin N-terminal domain SMYLE_N PF18615.1 ETO17949.1 - 0.37 10.3 8.9 0.41 10.1 8.9 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RR_TM4-6 PF06459.12 ETO17949.1 - 0.42 10.4 10.8 0.5 10.1 10.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF1387 PF07139.11 ETO17949.1 - 0.46 10.2 16.8 0.57 9.9 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Dicty_REP PF05086.12 ETO17949.1 - 0.48 8.4 19.3 0.54 8.2 19.3 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SOG2 PF10428.9 ETO17949.1 - 1.4 8.0 23.2 1.7 7.8 23.2 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4551 PF15087.6 ETO17949.1 - 1.6 7.5 15.4 1.8 7.3 15.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Use1 PF09753.9 ETO17949.1 - 4.3 7.0 9.5 5.6 6.6 9.5 1.3 1 0 0 1 1 1 0 Membrane fusion protein Use1 Transketolase_N PF00456.21 ETO17950.1 - 1.2e-110 369.6 0.0 1.4e-110 369.4 0.0 1.0 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.6 ETO17950.1 - 1.6e-07 30.8 0.0 1.8e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ETO17950.1 - 2.7e-05 24.0 0.0 4.7e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Terpene_synth PF01397.21 ETO17950.1 - 0.0037 17.0 0.0 0.0062 16.2 0.0 1.3 1 0 0 1 1 1 1 Terpene synthase, N-terminal domain E1_dh PF00676.20 ETO17950.1 - 0.0068 15.4 0.0 0.0086 15.1 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component Menin PF05053.13 ETO17951.1 - 3.7 5.8 19.1 4.3 5.6 19.1 1.0 1 0 0 1 1 1 0 Menin NOT2_3_5 PF04153.18 ETO17952.1 - 1.5e-19 70.4 6.7 1.5e-19 70.4 6.7 1.9 2 0 0 2 2 2 1 NOT2 / NOT3 / NOT5 family Scm3 PF10384.9 ETO17952.1 - 0.088 12.6 1.8 0.21 11.3 1.0 2.1 1 1 1 2 2 2 0 Centromere protein Scm3 Apis_Csd PF11671.8 ETO17952.1 - 5.5 7.0 19.1 2.4 8.2 15.6 2.0 2 0 0 2 2 2 0 Complementary sex determiner protein Kei1 PF08552.11 ETO17953.1 - 0.63 9.9 0.0 0.63 9.9 0.0 3.8 3 1 0 3 3 3 0 Inositolphosphorylceramide synthase subunit Kei1 DUF4203 PF13886.6 ETO17955.1 - 6.8e-15 55.3 20.4 3.6e-12 46.4 8.4 2.1 2 0 0 2 2 2 2 Domain of unknown function (DUF4203) DUF3392 PF11872.8 ETO17955.1 - 0.055 13.7 0.5 0.055 13.7 0.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3392) DUF5557 PF17712.1 ETO17955.1 - 0.12 12.3 1.3 0.17 11.8 0.2 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5557) DUF1904 PF08921.11 ETO17955.1 - 0.14 12.5 1.8 0.23 11.8 1.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) FtsX PF02687.21 ETO17955.1 - 0.34 11.4 13.8 1.5 9.3 0.2 3.1 2 1 0 2 2 2 0 FtsX-like permease family DUF1043 PF06295.12 ETO17955.1 - 0.74 9.8 3.7 0.44 10.5 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) DUF202 PF02656.15 ETO17955.1 - 5.1 7.6 7.9 4.1 7.9 0.2 3.0 2 2 0 2 2 2 0 Domain of unknown function (DUF202) SAM_1 PF00536.30 ETO17956.1 - 0.0036 17.7 0.3 0.011 16.2 0.3 1.8 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO17956.1 - 0.058 13.4 0.1 0.14 12.1 0.1 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Kelch_6 PF13964.6 ETO17957.1 - 1.8e-13 50.2 5.1 1.6e-05 25.0 0.6 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO17957.1 - 4.6e-10 38.9 1.4 2.9e-05 23.5 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO17957.1 - 0.00099 19.1 1.8 0.01 15.8 0.5 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO17957.1 - 0.0011 18.9 3.0 2.4 8.3 0.1 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO17957.1 - 0.0057 16.9 1.7 0.44 10.9 0.0 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO17957.1 - 0.27 11.3 4.3 0.53 10.3 0.1 3.5 3 1 1 4 4 4 0 Galactose oxidase, central domain REJ PF02010.15 ETO17958.1 - 1e-15 57.5 11.5 1.7e-15 56.8 11.5 1.3 1 0 0 1 1 1 1 REJ domain Actin PF00022.19 ETO17961.1 - 1.6e-45 155.5 0.0 1.7e-45 155.4 0.0 1.0 1 0 0 1 1 1 1 Actin SGS PF05002.15 ETO17961.1 - 0.06 13.5 0.0 0.09 12.9 0.0 1.3 1 0 0 1 1 1 0 SGS domain TPR_12 PF13424.6 ETO17962.1 - 1.6e-36 124.5 10.5 7.3e-13 48.6 0.0 4.7 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO17962.1 - 3.4e-27 93.5 0.8 5.2e-11 42.0 0.1 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO17962.1 - 1.3e-21 75.4 26.9 2.3e-07 30.3 0.8 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO17962.1 - 3.1e-21 73.8 21.3 1.7e-06 27.7 0.6 7.1 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO17962.1 - 7e-17 60.2 6.1 8.5e-05 22.3 0.0 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO17962.1 - 1.1e-15 56.3 25.3 3.8e-06 26.6 0.2 7.6 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO17962.1 - 1e-10 41.2 4.9 0.024 15.0 0.0 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat MIT PF04212.18 ETO17962.1 - 1.4e-06 28.2 7.3 0.022 14.8 0.1 4.8 5 0 0 5 5 4 1 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO17962.1 - 2.9e-06 27.7 0.0 4.9 8.2 0.0 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO17962.1 - 6.6e-06 26.7 0.2 0.21 12.3 0.0 3.9 4 1 0 4 4 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO17962.1 - 0.00015 22.2 5.2 3.4 8.5 0.0 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO17962.1 - 0.002 17.8 20.7 0.37 10.5 0.7 7.6 6 3 3 9 9 9 3 TPR repeat ANAPC3 PF12895.7 ETO17962.1 - 0.0026 17.9 4.0 0.16 12.2 0.0 2.8 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 ETO17962.1 - 0.0078 16.0 7.6 0.25 11.0 0.9 3.0 2 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETO17962.1 - 0.028 14.2 5.3 5.6 6.8 1.8 3.4 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO17962.1 - 0.033 14.2 9.2 0.14 12.2 0.5 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO17962.1 - 0.073 13.6 0.0 14 6.3 0.0 3.0 2 1 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 ETO17962.1 - 0.13 12.6 3.3 1.6 9.2 0.1 3.6 4 0 0 4 4 2 0 PPR repeat SHNi-TPR PF10516.9 ETO17962.1 - 0.13 11.7 0.0 48 3.5 0.0 3.6 3 0 0 3 3 3 0 SHNi-TPR DUF4816 PF16086.5 ETO17962.1 - 8.3 6.4 9.0 2.2 8.3 3.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4816) SnAC PF14619.6 ETO17963.1 - 0.027 15.1 0.8 0.057 14.0 0.8 1.6 1 0 0 1 1 1 0 Snf2-ATP coupling, chromatin remodelling complex AdenylateSensor PF16579.5 ETO17964.1 - 0.0077 16.7 0.2 0.024 15.1 0.2 1.8 1 1 0 1 1 1 1 Adenylate sensor of SNF1-like protein kinase Baculo_PEP_C PF04513.12 ETO17964.1 - 0.37 10.8 3.3 12 5.9 0.0 3.1 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Fungal_lectin_2 PF18647.1 ETO17964.1 - 2.9 8.4 5.8 1.1 9.8 1.6 2.5 2 2 0 2 2 2 0 Alpha-galactosyl-binding fungal lectin DUF2205 PF10224.9 ETO17964.1 - 6.6 6.8 11.6 0.32 11.0 1.9 3.1 2 1 1 3 3 3 0 Short coiled-coil protein Adhesin_E PF16747.5 ETO17965.1 - 0.0055 16.8 0.8 0.56 10.3 0.2 2.1 1 1 1 2 2 2 2 Surface-adhesin protein E YtxH PF12732.7 ETO17965.1 - 0.18 12.3 3.6 18 5.9 0.2 2.9 2 1 0 2 2 2 0 YtxH-like protein NodZ PF05830.11 ETO17966.1 - 3.8e-08 32.5 1.1 1.9e-06 27.0 0.0 2.7 3 0 0 3 3 3 2 Nodulation protein Z (NodZ) DUF1289 PF06945.13 ETO17966.1 - 0.38 10.6 2.0 6.5 6.7 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) Pro_isomerase PF00160.21 ETO17968.1 - 2.3e-45 154.7 0.1 2.6e-45 154.5 0.1 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD SBDS_C PF09377.10 ETO17968.1 - 0.13 12.3 0.0 0.23 11.5 0.0 1.3 1 0 0 1 1 1 0 SBDS protein C-terminal domain DUF563 PF04577.14 ETO17969.1 - 4.1e-05 23.8 0.0 9.1e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF563) JAKMIP_CC3 PF16034.5 ETO17972.1 - 2 8.3 33.0 2.5e+02 1.5 32.6 2.6 1 1 0 1 1 1 0 JAKMIP CC3 domain APG6_N PF17675.1 ETO17972.1 - 6.3 7.3 40.1 5.2 7.6 12.7 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region Fez1 PF06818.15 ETO17972.1 - 7.3 7.0 35.8 16 5.9 14.7 2.3 1 1 1 2 2 2 0 Fez1 Metallophos PF00149.28 ETO17973.1 - 0.0034 17.9 0.0 0.0056 17.2 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PAC1 PF16094.5 ETO17974.1 - 0.098 11.8 3.8 0.12 11.5 3.8 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 DUF4407 PF14362.6 ETO17974.1 - 0.32 10.3 13.3 0.41 10.0 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SpuA_C PF18033.1 ETO17974.1 - 0.51 10.4 2.0 0.4 10.8 0.3 1.7 2 0 0 2 2 2 0 SpuA C-terminal DUF4574 PF15141.6 ETO17974.1 - 0.96 9.4 5.7 3 7.8 5.7 1.9 1 1 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 Zip PF02535.22 ETO17974.1 - 2.4 7.3 4.4 2.5 7.2 4.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO17974.1 - 3.7 6.2 9.9 4.7 5.9 9.9 1.3 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETO17974.1 - 6.3 4.8 10.2 6.8 4.7 10.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Ferlin_C PF16165.5 ETO17974.1 - 7 6.6 13.5 16 5.4 13.5 1.6 1 0 0 1 1 1 0 Ferlin C-terminus POPLD PF08170.12 ETO17974.1 - 7.1 7.1 9.9 7.5 7.0 0.3 2.6 2 1 0 2 2 2 0 POPLD (NUC188) domain RNA_pol_Rpb2_4 PF04566.13 ETO17975.1 - 1.4e-19 70.1 0.0 3.1e-19 69.0 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 RNA_pol_Rpb2_2 PF04561.14 ETO17975.1 - 1.7e-09 37.6 0.1 0.00085 19.0 0.0 2.5 2 0 0 2 2 2 2 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_5 PF04567.17 ETO17975.1 - 3.3e-05 24.4 0.4 0.00012 22.6 0.0 2.2 3 0 0 3 3 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_3 PF04565.16 ETO17975.1 - 4.1e-05 23.7 0.0 0.00016 21.8 0.0 2.1 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 3 Chorion_2 PF03964.15 ETO17975.1 - 0.0022 18.8 7.0 0.0048 17.7 7.0 1.5 1 0 0 1 1 1 1 Chorion family 2 SR-25 PF10500.9 ETO17975.1 - 0.0027 17.3 17.5 0.0047 16.6 17.5 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Herpes_capsid PF06112.11 ETO17975.1 - 0.0055 16.8 6.4 0.009 16.1 6.4 1.3 1 0 0 1 1 1 1 Gammaherpesvirus capsid protein CCDC24 PF15669.5 ETO17975.1 - 0.013 15.4 1.9 0.023 14.6 1.9 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family MID_MedPIWI PF18296.1 ETO17975.1 - 0.046 13.5 1.0 0.066 13.0 1.0 1.2 1 0 0 1 1 1 0 MID domain of medPIWI CCDC106 PF15794.5 ETO17975.1 - 0.063 13.0 6.1 0.1 12.3 6.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF3446 PF11928.8 ETO17975.1 - 0.12 12.7 16.3 0.29 11.5 16.3 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain ANAPC1 PF12859.7 ETO17975.1 - 0.53 10.9 5.0 1.1 9.9 5.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 1 DUF4667 PF15700.5 ETO17975.1 - 0.55 10.3 10.8 0.91 9.6 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) Macoilin PF09726.9 ETO17975.1 - 0.83 8.1 6.4 1.2 7.7 6.4 1.1 1 0 0 1 1 1 0 Macoilin family FAM199X PF15814.5 ETO17975.1 - 1.1 8.3 15.7 1.8 7.6 15.7 1.2 1 0 0 1 1 1 0 Protein family FAM199X AF-4 PF05110.13 ETO17975.1 - 1.2 7.1 17.1 1.6 6.7 17.1 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF515 PF04415.12 ETO17975.1 - 2.3 6.5 11.2 12 4.2 12.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF515) DUF1635 PF07795.11 ETO17975.1 - 3.6 7.4 6.3 1.6 8.5 4.0 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1635) DUF508 PF04370.12 ETO17975.1 - 4.2 7.1 9.5 10 5.9 9.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Copine PF07002.16 ETO17976.1 - 5.3e-58 196.0 0.4 5.3e-58 196.0 0.4 1.5 2 0 0 2 2 2 1 Copine vWA-TerF-like PF10138.9 ETO17976.1 - 5.1e-06 26.7 0.0 7.7e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 vWA found in TerF C terminus LUD_dom PF02589.15 ETO17976.1 - 0.054 13.2 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 LUD domain Synapsin_C PF02750.14 ETO17977.1 - 3.3e-38 131.2 0.0 4e-38 131.0 0.0 1.1 1 0 0 1 1 1 1 Synapsin, ATP binding domain KIAA1430 PF13879.6 ETO17978.1 - 0.18 12.6 12.6 0.68 10.7 12.6 1.9 1 1 0 1 1 1 0 KIAA1430 homologue GPS PF01825.21 ETO17979.1 - 0.00028 21.3 1.4 0.00028 21.3 1.4 2.0 2 0 0 2 2 2 1 GPCR proteolysis site, GPS, motif Pkinase_Tyr PF07714.17 ETO17980.1 - 3.2e-46 157.7 0.0 4.3e-42 144.2 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO17980.1 - 3e-42 144.8 1.9 9e-42 143.2 0.0 2.6 2 2 1 3 3 3 1 Protein kinase domain UN_NPL4 PF11543.8 ETO17980.1 - 0.026 15.0 2.7 0.19 12.2 2.7 2.3 1 1 0 1 1 1 0 Nuclear pore localisation protein NPL4 baeRF_family10 PF18854.1 ETO17980.1 - 0.1 12.8 1.0 0.23 11.7 1.0 1.5 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 SelP_N PF04592.14 ETO17980.1 - 2.1 7.7 16.3 4.8 6.5 16.3 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region IL17R_fnIII_D2 PF16578.5 ETO17981.1 - 0.016 15.8 0.1 0.028 14.9 0.1 1.4 1 0 0 1 1 1 0 Interleukin 17 receptor D SR-25 PF10500.9 ETO17982.1 - 0.0001 22.0 7.7 0.0001 22.0 7.7 3.5 3 1 1 4 4 4 1 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 ETO17982.1 - 0.73 10.4 30.9 0.95 10.1 13.8 3.2 3 0 0 3 3 3 0 Secretin N-terminal domain IMUP PF15761.5 ETO17982.1 - 0.95 10.2 13.7 2.5 8.8 9.0 3.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein DUF3446 PF11928.8 ETO17982.1 - 6.9 7.0 23.0 0.71 10.2 11.7 3.6 4 0 0 4 4 4 0 Early growth response N-terminal domain DUF3802 PF12290.8 ETO17983.1 - 0.052 14.1 0.7 0.16 12.5 0.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3802) Mitochondr_Som1 PF11093.8 ETO17983.1 - 0.35 10.9 4.3 0.49 10.4 1.6 2.1 1 1 1 2 2 2 0 Mitochondrial export protein Som1 TFIIA PF03153.13 ETO17984.1 - 1.4e-15 58.2 9.7 1.9e-15 57.8 9.7 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit YabP PF07873.11 ETO17984.1 - 0.014 15.1 0.1 6.1 6.7 0.0 2.4 2 0 0 2 2 2 0 YabP family O-antigen_lig PF13425.6 ETO17984.1 - 4.6 5.9 6.8 5.5 5.7 6.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein LMBR1 PF04791.16 ETO17984.1 - 5.3 5.8 6.6 6.5 5.5 6.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Trypan_PARP PF05887.11 ETO17985.1 - 0.0077 16.2 8.3 0.019 15.0 8.3 1.6 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Abhydrolase_1 PF00561.20 ETO17986.1 - 0.00055 19.7 0.0 0.00057 19.6 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_4 PF08386.10 ETO17986.1 - 0.0042 17.2 0.0 0.0072 16.4 0.0 1.3 1 0 0 1 1 1 1 TAP-like protein Hydrolase_4 PF12146.8 ETO17986.1 - 0.052 12.8 0.0 0.067 12.4 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Peptidase_S15 PF02129.18 ETO17986.1 - 0.083 12.5 0.0 0.15 11.6 0.0 1.3 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETO17986.1 - 0.11 11.9 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 Prolyl oligopeptidase family Pkinase PF00069.25 ETO17989.1 - 3.3e-10 39.8 0.4 1.4e-07 31.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO17989.1 - 0.0026 17.1 0.0 0.0051 16.1 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TetR_C_8 PF14278.6 ETO17989.1 - 0.015 15.4 0.0 0.068 13.3 0.0 2.1 2 0 0 2 2 2 0 Transcriptional regulator C-terminal region DDE_3 PF13358.6 ETO17990.1 - 8.3e-07 28.9 1.1 1.5e-06 28.0 0.2 1.8 2 0 0 2 2 2 1 DDE superfamily endonuclease PH_4 PF15404.6 ETO17990.1 - 0.04 13.7 1.9 0.048 13.4 1.9 1.1 1 0 0 1 1 1 0 Pleckstrin homology domain PHA_synth_III_E PF09712.10 ETO17991.1 - 0.005 16.0 0.2 0.0055 15.8 0.2 1.2 1 0 0 1 1 1 1 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) AAA_lid_9 PF17871.1 ETO17991.1 - 0.0051 16.7 1.8 0.0079 16.1 1.8 1.5 1 0 0 1 1 1 1 AAA lid domain DUF1054 PF06335.12 ETO17991.1 - 0.02 14.9 0.8 0.027 14.4 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1054) 4HB_MCP_1 PF12729.7 ETO17991.1 - 0.095 12.2 9.6 0.041 13.4 5.6 2.1 1 1 1 2 2 2 0 Four helix bundle sensory module for signal transduction YtxH PF12732.7 ETO17991.1 - 0.58 10.7 3.0 3.2 8.4 3.0 2.0 1 1 0 1 1 1 0 YtxH-like protein DHFR_1 PF00186.19 ETO17992.1 - 4.6e-31 107.7 0.0 6.4e-31 107.2 0.0 1.3 1 0 0 1 1 1 1 Dihydrofolate reductase DUF1749 PF08538.10 ETO17992.1 - 0.068 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) Thymidylat_synt PF00303.19 ETO17993.1 - 2.4e-76 256.4 0.4 4.2e-71 239.2 0.1 2.2 1 1 1 2 2 2 2 Thymidylate synthase PDZ_3 PF17815.1 ETO17994.1 - 1.9e-43 147.8 0.0 3.3e-43 147.0 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO17994.1 - 0.011 16.0 0.7 0.71 10.2 0.0 2.7 3 0 0 3 3 3 0 PDZ domain PDZ_2 PF13180.6 ETO17995.1 - 0.042 14.2 0.0 0.089 13.1 0.0 1.5 2 0 0 2 2 2 0 PDZ domain Trypsin_2 PF13365.6 ETO17996.1 - 3e-09 37.9 0.0 3.4e-09 37.8 0.0 1.0 1 0 0 1 1 1 1 Trypsin-like peptidase domain DUF4590 PF15257.6 ETO17996.1 - 0.15 12.0 0.1 3.1 7.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4590) NST1 PF13945.6 ETO17997.1 - 1.3 9.1 28.9 1.7 8.7 28.9 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator TMEM151 PF14857.6 ETO17997.1 - 2.1 7.2 6.3 2.8 6.8 6.3 1.1 1 0 0 1 1 1 0 TMEM151 family ALMT PF11744.8 ETO17997.1 - 9.2 5.0 13.5 11 4.7 13.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4407 PF14362.6 ETO17997.1 - 9.8 5.4 9.6 11 5.2 9.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RNA_pol_Rpc4 PF05132.14 ETO18001.1 - 1.7e-07 31.8 27.8 0.0029 18.0 27.8 4.2 1 1 0 1 1 1 1 RNA polymerase III RPC4 CitMHS PF03600.16 ETO18002.1 - 0.077 12.2 0.0 0.095 11.9 0.0 1.1 1 0 0 1 1 1 0 Citrate transporter CD20 PF04103.15 ETO18002.1 - 0.98 9.5 2.4 2.7 8.1 0.3 2.9 2 1 0 2 2 2 0 CD20-like family UCH PF00443.29 ETO18003.1 - 2.3e-31 109.2 2.3 2.1e-30 106.1 2.3 2.1 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF5598 PF18127.1 ETO18003.1 - 0.083 13.3 0.1 0.33 11.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5598) CDC45 PF02724.14 ETO18003.1 - 0.097 10.9 4.1 0.13 10.5 4.1 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO18003.1 - 0.14 10.9 1.6 0.21 10.3 1.6 1.2 1 0 0 1 1 1 0 Presenilin Cytomega_UL84 PF06284.11 ETO18003.1 - 0.35 9.3 2.3 0.6 8.5 2.3 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein U79_P34 PF03064.16 ETO18003.1 - 1.6 8.0 11.4 2.7 7.3 11.4 1.3 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Pox_Ag35 PF03286.14 ETO18003.1 - 2.2 8.0 12.4 0.15 11.8 6.4 2.1 3 0 0 3 3 3 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO18003.1 - 2.7 6.0 11.2 4.3 5.3 11.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF2076 PF09849.9 ETO18003.1 - 4.6 7.2 9.7 8.7 6.3 9.7 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) FAM176 PF14851.6 ETO18003.1 - 6.8 6.3 9.9 0.98 9.1 2.7 2.5 3 0 0 3 3 3 0 FAM176 family UCH PF00443.29 ETO18004.1 - 1.2e-12 47.8 0.0 1.2e-12 47.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO18004.1 - 0.0077 15.9 0.0 0.0082 15.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO18005.1 - 6e-18 65.3 0.2 1e-17 64.5 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO18006.1 - 2.8e-16 59.8 0.3 3.6e-16 59.5 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO18006.1 - 9.9e-10 38.5 4.1 9.9e-10 38.5 4.1 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase GCP_C_terminal PF04130.13 ETO18007.1 - 5.8e-09 35.8 0.4 8.6e-09 35.3 0.4 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ETO18007.1 - 2.6e-07 30.6 0.0 4.3e-07 29.9 0.0 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal PmrD PF11183.8 ETO18007.1 - 0.016 15.4 0.6 0.5 10.5 0.2 2.3 2 0 0 2 2 2 0 Polymyxin resistance protein PmrD MIF4G_like PF09088.11 ETO18009.1 - 5e-21 75.4 1.3 1e-20 74.3 1.3 1.5 1 0 0 1 1 1 1 MIF4G like MIF4G PF02854.19 ETO18009.1 - 3.6e-10 39.8 6.9 1.9e-07 31.0 0.7 3.4 3 0 0 3 3 3 3 MIF4G domain DDHD PF02862.17 ETO18009.1 - 0.021 15.0 12.2 0.13 12.4 1.5 2.9 3 0 0 3 3 3 0 DDHD domain Velvet PF11754.8 ETO18009.1 - 0.034 14.1 0.3 0.034 14.1 0.3 2.6 2 1 0 2 2 2 0 Velvet factor OpcA PF07239.11 ETO18010.1 - 8.9e-08 32.1 1.9 1.2e-07 31.6 1.9 1.2 1 0 0 1 1 1 1 Outer membrane protein OpcA Ras PF00071.22 ETO18012.1 - 8.7e-37 126.2 0.2 8.9e-22 77.4 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO18012.1 - 6.7e-25 87.6 0.8 4.2e-11 43.1 0.0 2.7 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO18012.1 - 3.3e-11 43.0 0.1 5.9e-07 29.1 0.1 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family PduV-EutP PF10662.9 ETO18012.1 - 0.00016 21.4 0.3 0.035 13.9 0.1 2.4 2 0 0 2 2 2 2 Ethanolamine utilisation - propanediol utilisation TniB PF05621.11 ETO18012.1 - 0.0017 17.8 0.0 0.0041 16.6 0.0 1.6 2 0 0 2 2 2 1 Bacterial TniB protein Gtr1_RagA PF04670.12 ETO18012.1 - 0.0038 16.6 0.6 0.013 14.8 0.6 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ETO18012.1 - 0.02 14.0 0.9 0.1 11.7 0.2 2.0 1 1 1 2 2 2 0 G-protein alpha subunit DUF1593 PF07632.11 ETO18013.1 - 0.031 13.7 1.5 0.04 13.3 1.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1593) Tctex-1 PF03645.13 ETO18014.1 - 1e-06 28.9 4.9 1e-06 28.9 0.5 2.3 1 1 1 2 2 2 1 Tctex-1 family UPF0767 PF15990.5 ETO18014.1 - 2.6 8.2 6.9 1 9.5 0.2 2.3 2 0 0 2 2 2 0 UPF0767 family Fmp27 PF10344.9 ETO18015.1 - 0.00034 18.9 0.9 0.00046 18.5 0.9 1.3 1 0 0 1 1 1 1 Mitochondrial protein from FMP27 DUF2663 PF10864.8 ETO18015.1 - 0.02 15.3 0.5 0.049 14.0 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2663) RCC1 PF00415.18 ETO18017.1 - 1.6e-05 25.4 0.0 2.7e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO18017.1 - 0.73 9.7 6.3 1.2 9.1 0.5 3.1 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO18018.1 - 8.4e-16 57.3 5.6 2.3e-06 27.2 0.6 3.3 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO18018.1 - 2.6e-15 56.7 0.2 0.0003 21.4 0.0 4.7 4 1 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat CENP-O PF09496.10 ETO18020.1 - 0.00058 19.9 2.0 0.0011 19.0 2.0 1.5 1 0 0 1 1 1 1 Cenp-O kinetochore centromere component DUF2353 PF09789.9 ETO18020.1 - 0.037 13.4 15.1 0.021 14.2 11.9 2.1 1 1 0 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) RNR_N PF08343.10 ETO18020.1 - 0.54 10.3 3.9 19 5.4 1.1 2.4 2 0 0 2 2 2 0 Ribonucleotide reductase N-terminal CP12 PF02672.15 ETO18020.1 - 4.8 8.0 6.3 24 5.8 2.0 2.7 3 0 0 3 3 3 0 CP12 domain DUF2681 PF10883.8 ETO18020.1 - 8.5 6.9 13.6 7.6 7.0 6.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) zf-UBP PF02148.19 ETO18021.1 - 2e-14 53.6 7.5 5.7e-14 52.2 7.5 1.8 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein zf-UBP_var PF17807.1 ETO18021.1 - 0.022 14.5 1.4 0.067 12.9 1.4 1.8 1 0 0 1 1 1 0 Variant UBP zinc finger ABC_membrane PF00664.23 ETO18021.1 - 0.13 11.9 0.1 0.33 10.6 0.1 1.6 1 0 0 1 1 1 0 ABC transporter transmembrane region BRAP2 PF07576.12 ETO18022.1 - 0.0013 18.9 0.5 0.0013 18.9 0.5 3.1 3 1 0 3 3 3 1 BRCA1-associated protein 2 Methyltransf_12 PF08242.12 ETO18022.1 - 0.24 12.2 5.6 1.5 9.6 1.9 2.5 2 0 0 2 2 2 0 Methyltransferase domain Gti1_Pac2 PF09729.9 ETO18022.1 - 0.55 10.3 12.2 3.3 7.8 4.9 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family DUF3464 PF11947.8 ETO18022.1 - 0.66 9.7 4.6 2 8.2 0.5 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 ETO18022.1 - 0.91 8.2 11.3 0.51 9.0 4.5 2.1 2 0 0 2 2 2 0 Presenilin CPSF100_C PF13299.6 ETO18022.1 - 2.4 8.3 9.4 5.6 7.1 3.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Folate_carrier PF01770.18 ETO18022.1 - 3.3 6.3 4.9 10 4.7 0.2 2.3 2 0 0 2 2 2 0 Reduced folate carrier PDDEXK_6 PF04720.12 ETO18022.1 - 5.2 7.0 9.4 1.9 8.4 0.2 2.4 2 0 0 2 2 2 0 PDDEXK-like family of unknown function TetR_N PF00440.23 ETO18023.1 - 2.5e-16 59.2 0.1 5.7e-16 58.0 0.1 1.6 1 0 0 1 1 1 1 Bacterial regulatory proteins, tetR family TetR_C_21 PF17926.1 ETO18023.1 - 0.01 16.0 0.0 0.022 14.9 0.0 1.5 1 0 0 1 1 1 1 Tetracyclin repressor-like, C-terminal domain HTH_7 PF02796.15 ETO18023.1 - 0.029 14.5 0.0 4.8 7.3 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain of resolvase SwrA PF17423.2 ETO18024.1 - 0.0087 16.0 1.4 0.01 15.8 0.6 1.5 1 1 0 1 1 1 1 Swarming motility protein Fib_alpha PF08702.10 ETO18024.1 - 0.021 15.0 12.0 0.18 12.0 6.7 2.0 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family FAM76 PF16046.5 ETO18024.1 - 0.035 13.5 10.5 0.044 13.1 10.5 1.2 1 0 0 1 1 1 0 FAM76 protein NAS PF03059.16 ETO18024.1 - 0.037 13.4 0.9 0.045 13.1 0.9 1.1 1 0 0 1 1 1 0 Nicotianamine synthase protein TPR_MLP1_2 PF07926.12 ETO18024.1 - 0.047 13.7 16.2 0.11 12.5 10.3 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein MukF_M PF17192.4 ETO18024.1 - 0.1 12.4 6.1 0.097 12.4 3.7 1.9 1 1 1 2 2 2 0 MukF middle domain WXG100 PF06013.12 ETO18024.1 - 0.11 12.8 1.9 0.52 10.6 0.1 2.2 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Mga PF05043.13 ETO18024.1 - 0.12 13.0 3.5 0.2 12.3 1.0 2.3 1 1 1 2 2 2 0 Mga helix-turn-helix domain DUF4407 PF14362.6 ETO18024.1 - 0.17 11.2 3.3 0.21 10.9 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GCN5L1 PF06320.13 ETO18024.1 - 0.2 11.8 11.4 0.66 10.1 7.1 2.0 2 0 0 2 2 2 0 GCN5-like protein 1 (GCN5L1) Tnp_22_trimer PF17489.2 ETO18024.1 - 0.35 10.9 10.7 3.7 7.6 0.0 3.6 2 1 1 3 3 3 0 L1 transposable element trimerization domain Prefoldin PF02996.17 ETO18024.1 - 0.36 10.8 0.1 0.36 10.8 0.1 2.7 1 1 1 2 2 2 0 Prefoldin subunit Sec8_exocyst PF04048.14 ETO18024.1 - 0.4 10.6 9.4 3 7.7 4.8 2.4 1 1 0 2 2 2 0 Sec8 exocyst complex component specific domain Spc7 PF08317.11 ETO18024.1 - 0.64 8.8 16.8 1.1 8.1 16.8 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein Atg14 PF10186.9 ETO18024.1 - 1 8.4 8.8 1.1 8.3 8.8 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ATP-synt_E PF05680.12 ETO18024.1 - 1.1 9.6 8.5 0.18 12.2 4.4 1.8 2 0 0 2 2 2 0 ATP synthase E chain DUF1664 PF07889.12 ETO18024.1 - 1.2 9.1 13.0 1.7 8.7 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO18024.1 - 2.8 8.5 15.3 5.2 7.6 15.3 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region TMF_DNA_bd PF12329.8 ETO18024.1 - 4.7 7.3 22.0 6.5 6.8 15.2 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Seryl_tRNA_N PF02403.22 ETO18024.1 - 6.2 7.1 18.0 13 6.0 13.4 2.2 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF848 PF05852.11 ETO18024.1 - 7.3 6.7 13.5 8.4 6.5 9.7 2.0 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) TPR_2 PF07719.17 ETO18025.1 - 1.5e-12 46.6 9.8 0.029 14.5 0.1 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETO18025.1 - 1.3e-08 34.8 1.9 1.7e-06 28.1 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18025.1 - 2.9e-07 30.0 15.4 0.23 11.4 0.1 6.7 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO18025.1 - 2.8e-06 27.3 1.5 0.29 11.6 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ETO18025.1 - 3.3e-06 26.8 0.5 0.0058 16.3 0.0 3.3 3 0 0 3 3 3 1 Bacterial type III secretion protein (HrpB1_HrpK) TPR_19 PF14559.6 ETO18025.1 - 4e-06 27.3 1.7 0.021 15.3 0.0 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18025.1 - 4.7e-05 23.3 7.2 7.9 7.0 0.1 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18025.1 - 0.00013 22.5 0.8 2.4 9.2 0.6 4.9 3 2 2 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO18025.1 - 0.00021 21.4 6.8 0.0015 18.7 0.0 3.1 2 1 1 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 Paf67 PF10255.9 ETO18025.1 - 0.0035 16.4 1.2 0.015 14.4 0.1 2.0 2 0 0 2 2 2 1 RNA polymerase I-associated factor PAF67 TPR_16 PF13432.6 ETO18025.1 - 0.0055 17.3 0.0 35 5.1 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO18025.1 - 0.0065 16.7 6.1 4 7.8 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18025.1 - 0.013 15.5 2.5 18 5.6 0.1 4.5 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18025.1 - 0.016 14.8 4.3 4.1 7.2 0.1 4.7 4 1 1 5 5 5 0 TPR repeat DUF627 PF04781.12 ETO18025.1 - 0.032 14.2 0.4 1.6 8.8 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF627) YfiO PF13525.6 ETO18025.1 - 0.038 13.7 0.1 0.12 12.0 0.0 1.8 2 0 0 2 2 2 0 Outer membrane lipoprotein TPR_10 PF13374.6 ETO18025.1 - 0.054 13.4 1.7 45 4.1 0.0 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO18025.1 - 0.068 13.2 6.4 5.3 7.2 0.2 5.2 5 2 2 7 7 6 0 Fis1 C-terminal tetratricopeptide repeat DUF928 PF06051.12 ETO18025.1 - 0.072 12.9 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) DUF4849 PF16141.5 ETO18028.1 - 0.091 12.0 0.1 0.14 11.4 0.1 1.2 1 0 0 1 1 1 0 Putative glycoside hydrolase Family 18, chitinase_18 DUF3336 PF11815.8 ETO18029.1 - 0.012 15.3 1.1 0.015 15.0 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3336) DUF3347 PF11827.8 ETO18029.1 - 0.14 12.3 6.5 0.16 12.2 6.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3347) DUF4640 PF15480.6 ETO18029.1 - 0.23 11.2 5.9 0.31 10.8 5.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) DUF3090 PF11290.8 ETO18029.1 - 0.26 11.1 2.8 0.35 10.7 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3090) Borrelia_lipo_1 PF05714.11 ETO18029.1 - 0.43 10.3 11.8 1.4 8.6 10.3 2.1 1 1 1 2 2 2 0 Borrelia burgdorferi virulent strain associated lipoprotein YPEB PF14620.6 ETO18029.1 - 0.46 9.8 14.1 0.96 8.7 1.7 1.9 1 1 1 2 2 2 0 YpeB sporulation Atg14 PF10186.9 ETO18029.1 - 0.51 9.4 12.1 0.53 9.3 12.1 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 ABC_tran_CTD PF16326.5 ETO18029.1 - 4.8 7.5 17.6 0.53 10.6 7.6 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain Hydrolase_4 PF12146.8 ETO18030.1 - 4.8e-39 134.1 0.0 6.1e-39 133.7 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO18030.1 - 2.7e-08 34.7 0.0 4.2e-08 34.1 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ETO18030.1 - 3.8e-05 23.6 0.3 0.0067 16.3 0.1 2.9 2 1 0 2 2 2 1 Phospholipase/Carboxylesterase Esterase PF00756.20 ETO18030.1 - 0.00067 19.4 0.0 0.0012 18.5 0.0 1.4 2 0 0 2 2 2 1 Putative esterase Abhydrolase_3 PF07859.13 ETO18030.1 - 0.015 15.1 0.0 0.033 14.1 0.0 1.7 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETO18030.1 - 0.072 12.6 0.1 0.25 10.8 0.0 1.8 2 0 0 2 2 2 0 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ETO18030.1 - 0.076 12.6 1.4 12 5.4 1.0 2.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold TLD PF07534.16 ETO18031.1 - 1.9e-18 67.0 2.3 2.9e-18 66.4 2.3 1.3 1 0 0 1 1 1 1 TLD fn3 PF00041.21 ETO18031.1 - 0.11 12.9 0.0 0.59 10.5 0.0 2.2 2 0 0 2 2 2 0 Fibronectin type III domain CENP-P PF13096.6 ETO18031.1 - 0.18 11.5 0.0 0.29 10.8 0.0 1.2 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P NPR3 PF03666.13 ETO18031.1 - 0.78 8.5 10.3 1.1 8.0 10.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sec62 PF03839.16 ETO18031.1 - 0.8 9.2 8.2 0.15 11.6 4.0 1.8 2 0 0 2 2 2 0 Translocation protein Sec62 Vfa1 PF08432.10 ETO18031.1 - 2.8 8.2 16.9 6.1 7.1 16.9 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CCDC106 PF15794.5 ETO18031.1 - 6.9 6.3 13.8 12 5.5 13.8 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 FAM221 PF14753.6 ETO18033.1 - 0.0048 16.5 4.1 0.0076 15.8 4.1 1.3 1 0 0 1 1 1 1 Protein FAM221A/B FAD_SOX PF18371.1 ETO18034.1 - 0.041 14.3 1.3 0.069 13.5 0.7 1.6 2 0 0 2 2 2 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Secretin_N_2 PF07655.13 ETO18034.1 - 0.086 13.4 15.4 0.16 12.5 15.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Peroxin-13_N PF04088.13 ETO18034.1 - 1.6 9.0 4.0 5.2 7.3 1.3 2.2 1 1 1 2 2 2 0 Peroxin 13, N-terminal region Orf78 PF06024.12 ETO18034.1 - 1.7 9.0 10.8 2.9 8.2 10.8 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF2076 PF09849.9 ETO18034.1 - 9.4 6.2 12.0 13 5.7 12.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) MCM PF00493.23 ETO18035.1 - 0.061 12.4 0.1 0.12 11.5 0.1 1.3 1 0 0 1 1 1 0 MCM P-loop domain Membr_traf_MHD PF10540.9 ETO18035.1 - 0.21 11.7 4.0 1.5 9.0 4.0 2.4 1 1 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain ALMT PF11744.8 ETO18035.1 - 1.7 7.4 11.1 0.1 11.4 3.6 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter MID_MedPIWI PF18296.1 ETO18035.1 - 4 7.2 12.4 0.062 13.1 0.5 2.7 2 1 0 2 2 2 0 MID domain of medPIWI Zip PF02535.22 ETO18035.1 - 6.2 5.9 4.8 9.8 5.3 0.9 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Raftlin PF15250.6 ETO18038.1 - 2.4 6.8 17.4 0.4 9.4 7.4 2.1 2 0 0 2 2 2 0 Raftlin DAGK_cat PF00781.24 ETO18039.1 - 1.3e-05 24.8 0.2 4.3e-05 23.1 0.2 1.9 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain WSD PF15613.6 ETO18039.1 - 0.97 10.0 4.1 0.56 10.7 1.4 2.1 2 1 0 2 2 2 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Dicty_REP PF05086.12 ETO18040.1 - 4.4 5.2 7.9 5.9 4.7 7.9 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Macoilin PF09726.9 ETO18040.1 - 6.1 5.3 9.1 7.3 5.0 9.1 1.2 1 0 0 1 1 1 0 Macoilin family RRM_1 PF00076.22 ETO18041.1 - 0.0029 17.4 0.0 0.046 13.6 0.0 2.1 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Raco_middle PF17651.1 ETO18041.1 - 0.15 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 RACo middle region LPD29 PF18847.1 ETO18042.1 - 0.11 13.5 0.0 0.27 12.2 0.0 1.6 2 0 0 2 2 2 0 Large polyvalent protein associated domain 29 WD40 PF00400.32 ETO18043.1 - 9.3e-15 54.8 18.5 0.061 14.2 0.2 7.7 6 2 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18043.1 - 2.1e-11 44.0 0.0 8.7e-05 22.7 0.0 4.3 3 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO18043.1 - 0.18 10.5 3.6 1.3 7.7 3.6 2.6 1 1 0 1 1 1 0 Nup133 N terminal like Copine PF07002.16 ETO18044.1 - 4.1e-11 42.7 0.0 1.8e-10 40.6 0.0 1.9 1 1 0 1 1 1 1 Copine FAD_binding_4 PF01565.23 ETO18044.1 - 2.3e-05 24.2 0.0 4.5e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 FAD binding domain RimM PF01782.18 ETO18044.1 - 0.16 12.2 0.1 0.68 10.2 0.0 2.0 2 0 0 2 2 2 0 RimM N-terminal domain CdiA_C_tRNase PF18664.1 ETO18048.1 - 0.0056 16.9 1.6 0.033 14.4 0.1 2.4 1 1 2 3 3 3 1 CdiA C-terminal tRNase domain WD40 PF00400.32 ETO18049.1 - 1e-41 140.1 15.8 3.8e-06 27.5 0.1 8.1 8 1 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO18049.1 - 2.8e-17 62.6 7.8 0.0021 16.8 0.2 6.1 2 1 3 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO18049.1 - 2.1e-12 47.2 3.3 0.76 10.1 0.0 6.7 5 2 3 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO18049.1 - 0.008 15.0 4.2 0.35 9.6 0.1 3.6 2 1 1 3 3 3 2 Nup133 N terminal like Spc7 PF08317.11 ETO18049.1 - 0.63 8.9 20.5 0.9 8.4 20.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein zf-C4H2 PF10146.9 ETO18049.1 - 0.85 9.9 10.4 1.4 9.2 10.4 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF1664 PF07889.12 ETO18049.1 - 2.8 8.0 13.3 3.4 7.7 6.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Ras PF00071.22 ETO18051.1 - 5.1e-54 182.2 0.9 6.3e-54 181.9 0.9 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO18051.1 - 1.1e-28 99.9 0.4 1.8e-28 99.2 0.4 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO18051.1 - 9.2e-20 70.8 0.1 1.1e-19 70.5 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO18051.1 - 2.2e-09 37.0 0.1 2.9e-09 36.6 0.1 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO18051.1 - 9.3e-06 25.7 0.0 1.4e-05 25.1 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO18051.1 - 0.00015 21.3 0.1 0.0015 18.1 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETO18051.1 - 0.0044 16.5 0.0 0.007 15.8 0.0 1.3 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETO18051.1 - 0.012 15.5 0.1 0.31 11.0 0.0 2.3 1 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ETO18051.1 - 0.013 15.9 0.0 0.018 15.4 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain DAP3 PF10236.9 ETO18051.1 - 0.026 13.7 0.1 0.4 9.8 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_2 PF07724.14 ETO18051.1 - 0.033 14.3 0.1 4.5 7.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO18051.1 - 0.043 14.1 0.0 0.07 13.4 0.0 1.4 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ETO18051.1 - 0.051 12.7 0.8 2.6 7.1 0.0 2.3 1 1 1 2 2 2 0 G-protein alpha subunit AAA_24 PF13479.6 ETO18051.1 - 0.09 12.5 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain Septin PF00735.18 ETO18051.1 - 0.096 11.9 0.0 0.16 11.3 0.0 1.2 1 0 0 1 1 1 0 Septin Kelch_1 PF01344.25 ETO18052.1 - 6.5e-05 22.4 9.5 0.18 11.4 1.0 4.2 4 2 1 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ETO18052.1 - 0.01 16.1 0.0 2.8 8.4 0.0 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO18052.1 - 0.014 15.4 0.0 0.033 14.2 0.0 1.6 1 0 0 1 1 1 0 Kelch motif Pkinase PF00069.25 ETO18053.1 - 1.2e-11 44.4 1.5 2e-11 43.8 0.3 2.0 2 1 0 2 2 2 1 Protein kinase domain EF-hand_1 PF00036.32 ETO18053.1 - 0.034 13.7 0.3 0.098 12.3 0.3 1.9 1 0 0 1 1 1 0 EF hand EF-hand_7 PF13499.6 ETO18053.1 - 0.034 14.6 0.9 0.12 12.8 0.5 1.9 1 1 1 2 2 2 0 EF-hand domain pair DUF4020 PF13212.6 ETO18053.1 - 0.039 13.8 0.3 6.8 6.5 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4020) EF-hand_7 PF13499.6 ETO18054.1 - 2.6e-10 40.6 4.5 4.1e-10 40.0 4.5 1.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO18054.1 - 4.1e-10 38.5 9.4 1.6e-07 30.3 1.9 2.2 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO18054.1 - 2.9e-07 29.9 5.5 0.0011 18.7 0.3 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO18054.1 - 9.7e-07 28.5 4.0 1.3e-06 28.1 3.5 1.4 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO18054.1 - 1.8e-05 24.0 6.9 0.0038 16.7 0.7 2.3 2 0 0 2 2 2 2 EF hand EF-hand_4 PF12763.7 ETO18054.1 - 4.7e-05 23.3 0.8 5.7e-05 23.0 0.8 1.2 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ETO18054.1 - 0.0015 18.7 1.6 0.0024 18.0 1.6 1.4 1 1 0 1 1 1 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 ETO18054.1 - 0.0041 17.4 2.8 0.005 17.1 2.8 1.2 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Phytoreo_Pns PF05451.11 ETO18054.1 - 0.021 13.9 0.0 0.021 13.9 0.0 1.1 1 0 0 1 1 1 0 Phytoreovirus nonstructural protein Pns10/11 EF-hand_1 PF00036.32 ETO18056.1 - 1.6e-27 93.0 24.6 1.1e-08 34.1 0.7 5.3 5 1 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETO18056.1 - 9.1e-26 90.1 13.8 1.2e-14 54.5 1.2 2.7 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO18056.1 - 1.4e-24 85.7 9.1 6.9e-12 45.0 0.6 3.6 3 1 0 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO18056.1 - 3.5e-24 82.6 17.8 1.1e-07 31.3 0.6 5.5 5 1 1 6 6 6 4 EF-hand domain EF-hand_5 PF13202.6 ETO18056.1 - 2.4e-20 71.0 27.6 7.9e-06 25.1 1.4 5.9 5 2 1 6 6 6 4 EF hand EF-hand_9 PF14658.6 ETO18056.1 - 7.6e-09 35.8 0.2 0.0023 18.2 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETO18056.1 - 1.6e-06 28.0 7.0 0.00093 19.1 0.2 3.1 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO18056.1 - 0.00063 20.0 6.6 0.058 13.7 2.6 2.2 2 0 0 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region DUF3349 PF11829.8 ETO18056.1 - 0.0089 16.8 0.1 3.1 8.6 0.0 2.7 2 1 1 3 3 3 1 Protein of unknown function (DUF3349) GAPES1 PF17155.4 ETO18056.1 - 0.038 13.3 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain DUF1456 PF07308.13 ETO18056.1 - 0.22 11.9 1.6 13 6.3 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1456) Asp-B-Hydro_N PF05279.11 ETO18056.1 - 0.66 10.0 12.2 1.6 8.8 0.1 3.0 1 1 2 3 3 3 0 Aspartyl beta-hydroxylase N-terminal region RRN3 PF05327.11 ETO18057.1 - 0.0018 16.9 8.0 0.0018 16.9 8.0 2.3 2 1 0 2 2 2 1 RNA polymerase I specific transcription initiation factor RRN3 Pex19 PF04614.12 ETO18057.1 - 0.0026 17.6 16.8 0.0026 17.6 16.8 2.8 1 1 1 2 2 2 1 Pex19 protein family NdhL PF10716.9 ETO18057.1 - 0.012 15.6 1.2 0.022 14.7 1.2 1.3 1 0 0 1 1 1 0 NADH dehydrogenase transmembrane subunit DUF5436 PF17504.2 ETO18057.1 - 0.16 12.3 1.3 0.5 10.7 1.3 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5436) Connexin PF00029.19 ETO18057.1 - 0.65 9.7 17.5 0.018 14.8 3.7 2.4 2 1 0 2 2 2 0 Connexin CDC45 PF02724.14 ETO18057.1 - 3.2 5.9 19.8 0.61 8.3 2.5 2.1 2 0 0 2 2 2 0 CDC45-like protein ABC2_membrane_3 PF12698.7 ETO18057.1 - 3.5 6.6 12.5 0.042 13.0 1.4 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein Rxt3 PF08642.10 ETO18057.1 - 9.8 7.0 11.3 6.7 7.5 2.9 2.6 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 SNF2_N PF00176.23 ETO18059.1 - 5.5e-24 84.5 0.0 8.4e-24 83.9 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO18059.1 - 1.5e-07 31.6 0.0 3.1e-07 30.6 0.0 1.5 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit Thyroglobulin_1 PF00086.18 ETO18060.1 - 0.048 13.3 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Thyroglobulin type-1 repeat Herpes_UL49_1 PF03117.14 ETO18060.1 - 0.06 12.6 0.1 0.095 12.0 0.1 1.2 1 0 0 1 1 1 0 UL49 family PQQ_3 PF13570.6 ETO18060.1 - 0.06 13.8 0.4 1.2 9.8 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain G-alpha PF00503.20 ETO18061.1 - 5e-30 104.8 8.0 8e-30 104.2 8.0 1.3 1 1 0 1 1 1 1 G-protein alpha subunit MAD PF05557.13 ETO18062.1 - 0.0013 17.2 37.6 0.0016 16.9 37.6 1.0 1 0 0 1 1 1 1 Mitotic checkpoint protein UPF0242 PF06785.11 ETO18062.1 - 0.011 15.8 17.1 0.011 15.8 17.1 2.9 1 1 2 3 3 2 0 Uncharacterised protein family (UPF0242) N-terminus IBP39 PF11422.8 ETO18062.1 - 0.025 14.4 2.8 1.9 8.2 0.7 2.3 1 1 1 2 2 2 0 Initiator binding protein 39 kDa DivIVA PF05103.13 ETO18062.1 - 0.043 13.9 1.1 0.043 13.9 1.1 3.6 1 1 2 3 3 3 0 DivIVA protein FlaC_arch PF05377.11 ETO18062.1 - 0.078 13.4 2.1 0.078 13.4 2.1 4.8 3 2 1 4 4 3 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 ETO18062.1 - 0.19 12.1 0.3 0.19 12.1 0.3 3.6 2 1 0 2 2 1 0 Centromere protein H (CENP-H) DUF948 PF06103.11 ETO18062.1 - 0.2 11.9 0.3 0.2 11.9 0.3 3.5 3 2 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1722 PF08349.11 ETO18062.1 - 0.21 11.9 10.4 0.083 13.2 5.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) SHE3 PF17078.5 ETO18062.1 - 0.31 10.7 32.0 0.45 10.2 32.0 1.2 1 0 0 1 1 1 0 SWI5-dependent HO expression protein 3 TACC_C PF05010.14 ETO18062.1 - 0.43 10.3 36.6 0.46 10.2 15.6 2.3 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal MtrG PF04210.13 ETO18062.1 - 0.85 9.5 4.7 1.7 8.5 0.1 3.4 3 1 1 4 4 4 0 Tetrahydromethanopterin S-methyltransferase, subunit G Exonuc_VII_L PF02601.15 ETO18062.1 - 0.87 9.1 29.9 0.66 9.5 10.8 2.0 1 1 1 2 2 2 0 Exonuclease VII, large subunit Prominin PF05478.11 ETO18062.1 - 1.4 6.8 22.1 2.2 6.2 22.1 1.3 1 0 0 1 1 1 0 Prominin DUF4763 PF15960.5 ETO18062.1 - 1.6 8.0 31.4 1.7 7.9 3.2 2.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4763) ABC_tran_CTD PF16326.5 ETO18062.1 - 2.2 8.6 36.5 2.8 8.3 0.3 4.6 2 1 2 4 4 4 0 ABC transporter C-terminal domain TMPIT PF07851.13 ETO18062.1 - 2.3 7.4 32.9 3.3 6.9 11.1 3.0 1 1 2 3 3 3 0 TMPIT-like protein YabA PF06156.13 ETO18062.1 - 2.6 8.7 34.8 0.74 10.5 2.3 4.0 1 1 2 3 3 3 0 Initiation control protein YabA MscS_porin PF12795.7 ETO18062.1 - 2.9 7.4 35.1 8.1 5.9 31.3 2.4 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain SKA2 PF16740.5 ETO18062.1 - 3 7.6 31.0 0.43 10.4 2.0 3.4 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 2 Filament PF00038.21 ETO18062.1 - 3.1 7.3 35.6 2.3 7.7 15.7 2.5 1 1 1 2 2 2 0 Intermediate filament protein TPR_MLP1_2 PF07926.12 ETO18062.1 - 3.2 7.8 45.1 1.5 8.9 1.4 3.7 1 1 1 3 3 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO18062.1 - 3.7 6.8 23.7 86 2.3 23.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ZapB PF06005.12 ETO18062.1 - 5.3 7.6 47.2 0.18 12.3 1.2 4.2 2 1 1 3 3 2 0 Cell division protein ZapB Occludin_ELL PF07303.13 ETO18062.1 - 5.8 7.7 22.7 0.24 12.2 5.1 3.1 1 1 2 3 3 3 0 Occludin homology domain ATG16 PF08614.11 ETO18062.1 - 7.1 6.8 42.2 3.3 7.9 7.9 3.3 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 ETO18062.1 - 7.2 7.2 44.2 1.6 9.3 6.4 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region Spc7 PF08317.11 ETO18062.1 - 7.7 5.3 43.2 2.7 6.8 28.7 3.0 1 1 2 3 3 3 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ETO18063.1 - 8.1e-05 22.9 18.1 0.068 13.6 1.8 3.1 3 0 0 3 3 3 2 Flagella accessory protein C (FlaC) BLOC1_2 PF10046.9 ETO18063.1 - 0.00098 19.4 15.0 0.0044 17.3 8.7 2.7 2 1 0 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 HMMR_N PF15905.5 ETO18063.1 - 0.0018 17.8 20.1 0.0022 17.6 20.1 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal SHE3 PF17078.5 ETO18063.1 - 0.0021 17.8 15.0 0.0029 17.4 15.0 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 bZIP_1 PF00170.21 ETO18063.1 - 0.0026 17.8 21.5 0.012 15.7 2.7 3.2 2 1 1 3 3 3 1 bZIP transcription factor Herpes_BLRF2 PF05812.12 ETO18063.1 - 0.0028 17.8 0.9 0.0028 17.8 0.9 2.5 2 1 0 2 2 2 1 Herpesvirus BLRF2 protein TSC22 PF01166.18 ETO18063.1 - 0.0035 17.6 14.2 0.0051 17.1 0.7 3.6 2 1 0 2 2 2 1 TSC-22/dip/bun family DUF1664 PF07889.12 ETO18063.1 - 0.0056 16.7 12.7 0.017 15.1 5.3 2.6 1 1 2 3 3 3 2 Protein of unknown function (DUF1664) CLZ PF16526.5 ETO18063.1 - 0.0077 16.6 17.5 0.011 16.1 5.0 2.8 1 1 2 3 3 3 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Cortex-I_coil PF09304.10 ETO18063.1 - 0.0087 16.3 7.5 0.0087 16.3 7.5 2.1 1 1 1 2 2 2 1 Cortexillin I, coiled coil TolA_bind_tri PF16331.5 ETO18063.1 - 0.0091 16.1 19.9 0.038 14.1 2.9 2.8 1 1 0 2 2 2 1 TolA binding protein trimerisation DUF2120 PF09893.9 ETO18063.1 - 0.0092 16.1 5.4 0.013 15.6 5.4 1.3 1 0 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2120) MscS_porin PF12795.7 ETO18063.1 - 0.0099 15.5 17.6 0.012 15.1 17.6 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain SlyX PF04102.12 ETO18063.1 - 0.013 16.1 15.1 0.23 12.1 2.5 2.5 1 1 1 2 2 2 0 SlyX GAS PF13851.6 ETO18063.1 - 0.018 14.4 19.6 0.026 13.9 17.8 1.8 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 ETO18063.1 - 0.02 14.5 19.7 0.45 10.1 1.4 2.0 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease TPR_MLP1_2 PF07926.12 ETO18063.1 - 0.021 14.9 19.5 0.049 13.7 19.5 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DivIC PF04977.15 ETO18063.1 - 0.031 14.0 24.0 0.082 12.7 3.6 3.1 1 1 2 3 3 3 0 Septum formation initiator HrpB7 PF09486.10 ETO18063.1 - 0.033 14.6 5.1 0.41 11.0 5.2 2.0 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Filament PF00038.21 ETO18063.1 - 0.04 13.5 16.7 0.17 11.5 6.6 2.1 1 1 1 2 2 2 0 Intermediate filament protein BRE1 PF08647.11 ETO18063.1 - 0.041 13.9 21.2 0.066 13.3 10.1 2.1 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3557 PF12078.8 ETO18063.1 - 0.051 13.5 2.3 0.058 13.4 1.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3557) DUF3584 PF12128.8 ETO18063.1 - 0.066 10.7 13.3 0.081 10.4 13.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Bap31_Bap29_C PF18035.1 ETO18063.1 - 0.068 13.2 24.2 0.068 13.2 5.1 3.9 1 1 2 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF3450 PF11932.8 ETO18063.1 - 0.087 12.1 18.7 0.13 11.6 8.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4200 PF13863.6 ETO18063.1 - 0.1 13.0 19.0 0.39 11.1 18.7 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) Phage_GP20 PF06810.11 ETO18063.1 - 0.1 12.4 18.5 2.3 8.0 3.7 2.5 1 1 1 2 2 2 0 Phage minor structural protein GP20 DUF16 PF01519.16 ETO18063.1 - 0.13 12.7 19.1 0.76 10.3 9.2 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF16 DUF2959 PF11172.8 ETO18063.1 - 0.14 12.3 9.7 1.3 9.1 9.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2959) XhlA PF10779.9 ETO18063.1 - 0.14 12.4 19.0 0.11 12.7 1.5 3.1 2 1 1 3 3 3 0 Haemolysin XhlA GrpE PF01025.19 ETO18063.1 - 0.15 11.7 14.7 0.35 10.5 6.3 2.1 1 1 1 2 2 2 0 GrpE DUF5082 PF16888.5 ETO18063.1 - 0.16 12.3 15.8 1.5 9.1 2.8 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) EzrA PF06160.12 ETO18063.1 - 0.16 10.1 15.4 0.42 8.7 15.4 1.5 1 1 0 1 1 1 0 Septation ring formation regulator, EzrA Jnk-SapK_ap_N PF09744.9 ETO18063.1 - 0.18 12.1 19.8 0.43 10.8 19.7 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Fmp27_WPPW PF10359.9 ETO18063.1 - 0.18 10.6 11.6 0.23 10.3 11.6 1.2 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain ABC_tran_CTD PF16326.5 ETO18063.1 - 0.18 12.1 14.9 0.19 12.0 2.5 3.0 1 1 2 3 3 3 0 ABC transporter C-terminal domain HAP1_N PF04849.13 ETO18063.1 - 0.19 10.9 19.0 0.38 9.9 19.0 1.5 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Spc7 PF08317.11 ETO18063.1 - 0.21 10.4 20.2 2.7 6.8 19.6 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein APG17 PF04108.12 ETO18063.1 - 0.24 10.5 13.9 0.33 10.0 13.9 1.2 1 0 0 1 1 1 0 Autophagy protein Apg17 Vps5 PF09325.10 ETO18063.1 - 0.26 10.8 14.3 0.46 10.0 7.1 2.1 1 1 1 2 2 2 0 Vps5 C terminal like IFT57 PF10498.9 ETO18063.1 - 0.29 10.1 16.7 0.25 10.2 8.1 1.9 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Prefoldin_2 PF01920.20 ETO18063.1 - 0.3 11.1 22.3 1.4 9.0 4.4 3.1 2 1 1 3 3 3 0 Prefoldin subunit CENP-F_leu_zip PF10473.9 ETO18063.1 - 0.37 10.8 23.3 2.8 7.9 3.0 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 ETO18063.1 - 0.4 10.9 20.1 2.3 8.4 20.1 2.0 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Golgin_A5 PF09787.9 ETO18063.1 - 0.42 10.0 16.5 0.66 9.4 16.5 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 Baculo_PEP_C PF04513.12 ETO18063.1 - 0.42 10.6 11.7 0.85 9.7 4.1 2.1 1 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus AAA_13 PF13166.6 ETO18063.1 - 0.43 9.2 14.5 1.3 7.5 1.4 1.9 1 1 1 2 2 2 0 AAA domain DUF2316 PF10078.9 ETO18063.1 - 0.43 10.8 7.3 0.56 10.5 0.7 2.5 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2316) DUF2443 PF10398.9 ETO18063.1 - 0.45 10.6 7.6 0.77 9.8 0.2 3.2 1 1 2 3 3 3 0 Protein of unknown function (DUF2443) Prefoldin PF02996.17 ETO18063.1 - 0.47 10.4 19.3 0.62 10.0 2.2 3.1 1 1 2 3 3 3 0 Prefoldin subunit RasGAP_C PF03836.15 ETO18063.1 - 0.52 10.5 17.1 0.77 9.9 5.9 2.1 1 1 1 2 2 2 0 RasGAP C-terminus Exonuc_VII_S PF02609.16 ETO18063.1 - 0.55 10.3 12.1 0.56 10.3 0.6 3.2 4 0 0 4 4 2 0 Exonuclease VII small subunit UPF0242 PF06785.11 ETO18063.1 - 0.56 10.3 19.5 0.83 9.7 19.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 ETO18063.1 - 0.56 10.5 14.4 2.5 8.5 5.5 2.2 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) YabA PF06156.13 ETO18063.1 - 0.64 10.7 15.4 4.8 7.9 5.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA SLIDE PF09111.10 ETO18063.1 - 0.64 10.1 10.8 1.3 9.1 1.9 2.3 1 1 1 2 2 2 0 SLIDE Imm3 PF14425.6 ETO18063.1 - 0.65 10.0 7.4 1.5 8.9 1.7 2.2 2 0 0 2 2 2 0 Immunity protein Imm3 DUF4164 PF13747.6 ETO18063.1 - 0.66 10.3 13.7 1.6 9.1 7.9 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4164) Ax_dynein_light PF10211.9 ETO18063.1 - 0.67 9.9 19.8 1.2 9.0 9.1 2.2 1 1 1 2 2 2 0 Axonemal dynein light chain ZapB PF06005.12 ETO18063.1 - 0.71 10.4 24.6 1.8e+04 -6.5 24.6 3.1 1 1 0 1 1 0 0 Cell division protein ZapB THOC7 PF05615.13 ETO18063.1 - 0.73 10.1 19.2 1 9.6 10.4 2.3 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4404 PF14357.6 ETO18063.1 - 0.74 10.5 19.7 3.1 8.5 8.8 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4404) PRKG1_interact PF15898.5 ETO18063.1 - 0.85 10.6 17.3 2.1 9.3 16.8 2.0 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain ApoO PF09769.9 ETO18063.1 - 0.92 9.5 3.5 0.86 9.6 1.5 1.8 1 1 1 2 2 2 0 Apolipoprotein O DUF724 PF05266.14 ETO18063.1 - 1 9.2 16.2 2.7 7.8 6.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ACCA PF03255.14 ETO18063.1 - 1.1 9.2 12.0 0.7 9.8 2.4 2.6 1 1 2 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Exonuc_VII_L PF02601.15 ETO18063.1 - 1.1 8.8 11.9 1.2 8.6 11.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TMF_DNA_bd PF12329.8 ETO18063.1 - 1.2 9.2 25.3 2.7 8.1 5.4 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding WXG100 PF06013.12 ETO18063.1 - 1.2 9.4 7.4 0.9 9.8 2.3 2.5 2 1 0 2 2 2 0 Proteins of 100 residues with WXG Nnf1 PF03980.14 ETO18063.1 - 1.3 9.4 19.4 0.4 11.1 1.7 3.1 1 1 1 3 3 3 0 Nnf1 Goodbye PF17109.5 ETO18063.1 - 1.4 9.4 8.4 4.1 7.9 2.2 2.2 1 1 1 2 2 2 0 fungal STAND N-terminal Goodbye domain Fzo_mitofusin PF04799.13 ETO18063.1 - 1.5 8.4 11.8 0.21 11.2 5.8 2.0 1 1 1 2 2 2 0 fzo-like conserved region CREPT PF16566.5 ETO18063.1 - 1.6 8.9 13.8 1.7 8.8 6.2 2.0 1 1 1 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour ADIP PF11559.8 ETO18063.1 - 1.6 8.8 20.5 1.7 8.7 13.4 2.0 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding Bcr-Abl_Oligo PF09036.10 ETO18063.1 - 1.6 8.8 7.8 0.51 10.4 0.9 2.5 1 1 2 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Fungal_TACC PF12709.7 ETO18063.1 - 1.7 9.2 20.4 4.1 7.9 2.6 3.2 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins Osmo_CC PF08946.10 ETO18063.1 - 2 8.8 9.5 29 5.0 0.2 3.8 3 1 0 3 3 3 0 Osmosensory transporter coiled coil Atg14 PF10186.9 ETO18063.1 - 2 7.4 17.6 0.87 8.6 7.3 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 TraF_2 PF13729.6 ETO18063.1 - 2 7.7 5.6 1.5 8.1 3.5 1.7 1 1 1 2 2 2 0 F plasmid transfer operon, TraF, protein Bacillus_HBL PF05791.11 ETO18063.1 - 2.1 8.2 13.5 16 5.3 13.5 1.9 1 1 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) TMPIT PF07851.13 ETO18063.1 - 2.1 7.5 15.6 4.3 6.5 6.2 1.9 1 1 1 2 2 2 0 TMPIT-like protein DUF4795 PF16043.5 ETO18063.1 - 2.2 7.8 19.7 16 5.0 19.7 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) Fib_alpha PF08702.10 ETO18063.1 - 2.3 8.4 14.9 14 5.8 14.7 2.0 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4845 PF16137.5 ETO18063.1 - 2.7 8.9 5.4 0.99 10.3 0.7 2.2 2 1 1 3 3 2 0 Domain of unknown function (DUF4845) DUF4407 PF14362.6 ETO18063.1 - 2.9 7.2 11.4 5.5 6.2 11.4 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Rho_Binding PF08912.11 ETO18063.1 - 3 8.7 21.7 1 10.2 1.9 3.0 2 1 1 3 3 3 0 Rho Binding Swi5 PF07061.11 ETO18063.1 - 3.1 7.9 19.2 2.4 8.3 1.2 3.3 1 1 2 3 3 3 0 Swi5 Tup_N PF08581.10 ETO18063.1 - 3.4 8.0 15.7 8.9 6.7 7.2 2.3 1 1 1 2 2 2 0 Tup N-terminal APG6_N PF17675.1 ETO18063.1 - 3.4 8.2 20.8 16 6.0 11.0 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region KxDL PF10241.9 ETO18063.1 - 3.6 7.9 14.5 6.2 7.2 5.9 2.1 1 1 0 2 2 2 0 Uncharacterized conserved protein DUF948 PF06103.11 ETO18063.1 - 3.7 7.9 7.5 59 4.0 7.5 2.4 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) BST2 PF16716.5 ETO18063.1 - 3.8 8.1 21.3 3.3 8.4 3.9 2.8 1 1 0 2 2 2 0 Bone marrow stromal antigen 2 Spc24 PF08286.11 ETO18063.1 - 3.9 7.8 22.1 5.5 7.3 3.0 3.0 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 DUF489 PF04356.12 ETO18063.1 - 3.9 7.4 7.8 7.8 6.5 1.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF489) PNPase PF03726.14 ETO18063.1 - 4.1 8.0 8.2 3.2 8.3 5.1 2.2 1 1 1 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain bZIP_2 PF07716.15 ETO18063.1 - 4.6 7.4 19.1 3.1 8.0 1.3 3.5 3 1 0 3 3 3 0 Basic region leucine zipper SKA1 PF07160.12 ETO18063.1 - 4.7 7.0 14.4 9.3 6.0 5.7 2.0 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 Csm1_N PF18504.1 ETO18063.1 - 6 7.3 22.1 8 6.9 2.4 3.5 1 1 3 4 4 4 0 Csm1 N-terminal domain Mt_ATP-synt_D PF05873.12 ETO18063.1 - 6.4 6.6 9.4 18 5.2 3.4 2.3 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) HIP1_clath_bdg PF16515.5 ETO18063.1 - 7.3 7.3 21.3 7.4 7.3 11.0 2.3 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Sec5 PF15469.6 ETO18063.1 - 8.7 6.1 15.9 3.7 7.3 6.7 2.2 1 1 1 2 2 2 0 Exocyst complex component Sec5 ALMT PF11744.8 ETO18063.1 - 9.1 5.0 9.5 10 4.8 9.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Lebercilin PF15619.6 ETO18064.1 - 2.6e-05 23.9 26.9 3.8e-05 23.4 26.9 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease Fez1 PF06818.15 ETO18064.1 - 0.00046 20.7 22.7 0.00059 20.3 22.7 1.1 1 0 0 1 1 1 1 Fez1 CENP-F_leu_zip PF10473.9 ETO18064.1 - 0.0013 18.8 8.6 0.0013 18.8 8.6 3.3 1 1 2 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 ETO18064.1 - 0.0033 17.4 9.7 0.0033 17.4 9.7 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF1664) Spc7 PF08317.11 ETO18064.1 - 0.0057 15.6 20.2 0.0057 15.6 20.2 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein MAD PF05557.13 ETO18064.1 - 0.012 14.0 26.0 0.017 13.6 26.0 1.2 1 0 0 1 1 1 0 Mitotic checkpoint protein ADIP PF11559.8 ETO18064.1 - 0.019 15.0 27.6 0.099 12.7 8.1 2.3 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.11 ETO18064.1 - 0.025 13.4 24.2 0.05 12.5 24.2 1.4 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Laminin_II PF06009.12 ETO18064.1 - 0.029 14.4 17.3 0.33 11.0 8.2 2.1 1 1 1 2 2 2 0 Laminin Domain II Vac_Fusion PF02346.16 ETO18064.1 - 0.049 13.3 0.8 0.049 13.3 0.8 3.0 2 1 0 3 3 2 0 Chordopoxvirus multifunctional envelope protein A27 DMPK_coil PF08826.10 ETO18064.1 - 0.064 13.4 17.8 0.051 13.7 3.6 3.2 2 2 0 2 2 2 0 DMPK coiled coil domain like Filament PF00038.21 ETO18064.1 - 0.065 12.8 22.1 1.1 8.8 7.7 2.1 1 1 1 2 2 2 0 Intermediate filament protein MscS_porin PF12795.7 ETO18064.1 - 0.071 12.6 23.9 0.018 14.6 14.8 2.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain MID_pPIWI_RE PF18157.1 ETO18064.1 - 0.072 13.4 3.3 0.059 13.7 1.5 1.8 1 1 1 2 2 2 0 MID domain of pPIWI_RE Golgin_A5 PF09787.9 ETO18064.1 - 0.072 12.5 25.9 0.087 12.3 19.1 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 ERM PF00769.19 ETO18064.1 - 0.085 12.7 24.6 0.12 12.2 24.6 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family HIP1_clath_bdg PF16515.5 ETO18064.1 - 0.11 13.1 29.6 0.067 13.8 10.3 2.8 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TMF_TATA_bd PF12325.8 ETO18064.1 - 0.15 12.3 22.9 0.15 12.3 5.6 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding FPP PF05911.11 ETO18064.1 - 0.16 10.1 28.8 0.1 10.8 25.9 1.8 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil Transcrip_act PF04949.13 ETO18064.1 - 0.21 11.5 14.8 0.19 11.6 9.7 2.2 1 1 1 2 2 2 0 Transcriptional activator ATG16 PF08614.11 ETO18064.1 - 0.24 11.6 24.5 0.18 12.0 6.8 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) HMMR_N PF15905.5 ETO18064.1 - 0.25 10.8 29.9 0.41 10.1 15.3 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal CENP-H PF05837.12 ETO18064.1 - 0.27 11.7 22.5 0.62 10.5 9.1 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Tropomyosin PF00261.20 ETO18064.1 - 0.29 10.5 23.0 0.031 13.7 15.4 2.2 1 1 1 2 2 2 0 Tropomyosin DUF812 PF05667.11 ETO18064.1 - 0.31 9.9 25.4 0.4 9.5 25.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) HrpB7 PF09486.10 ETO18064.1 - 0.32 11.4 8.9 0.43 10.9 8.9 1.1 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF948 PF06103.11 ETO18064.1 - 0.36 11.1 10.9 0.29 11.4 4.7 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) BRE1 PF08647.11 ETO18064.1 - 0.49 10.5 28.3 0.47 10.6 11.7 3.2 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase Fib_alpha PF08702.10 ETO18064.1 - 0.6 10.3 19.9 1.2 9.3 19.3 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 ETO18064.1 - 0.63 10.7 20.9 0.082 13.5 2.9 3.5 1 1 2 3 3 3 0 SlyX TMPIT PF07851.13 ETO18064.1 - 0.78 8.9 16.5 0.12 11.6 11.6 1.8 1 1 1 2 2 2 0 TMPIT-like protein V_ATPase_I PF01496.19 ETO18064.1 - 0.8 7.5 13.3 1 7.2 13.3 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4140 PF13600.6 ETO18064.1 - 0.81 10.2 11.3 0.11 13.0 4.0 2.3 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) DUF4164 PF13747.6 ETO18064.1 - 0.94 9.8 12.3 0.71 10.2 6.2 2.6 1 1 1 3 3 3 0 Domain of unknown function (DUF4164) DUF2935 PF11155.8 ETO18064.1 - 1.1 9.7 8.1 1.2 9.5 5.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) DLP_helical PF18709.1 ETO18064.1 - 1.1 8.4 16.5 0.13 11.4 3.3 2.4 1 1 1 2 2 2 0 Dynamin-like helical domain IFT57 PF10498.9 ETO18064.1 - 1.1 8.1 23.0 3.4 6.5 23.0 1.7 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 Prominin PF05478.11 ETO18064.1 - 1.4 6.8 15.9 0.28 9.1 11.1 1.7 1 1 1 2 2 2 0 Prominin SYCE1 PF15233.6 ETO18064.1 - 1.5 8.9 27.2 0.39 10.8 18.7 2.1 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 NPV_P10 PF05531.12 ETO18064.1 - 1.6 9.3 13.1 0.4 11.2 4.8 2.9 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3584 PF12128.8 ETO18064.1 - 2.1 5.8 21.8 3.1 5.2 21.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) GAS PF13851.6 ETO18064.1 - 2.1 7.7 28.6 0.99 8.7 13.1 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TMF_DNA_bd PF12329.8 ETO18064.1 - 2.5 8.2 29.6 0.42 10.7 6.3 3.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Exonuc_VII_L PF02601.15 ETO18064.1 - 3.1 7.3 17.4 5.3 6.5 16.6 1.6 1 1 0 1 1 1 0 Exonuclease VII, large subunit BST2 PF16716.5 ETO18064.1 - 3.2 8.4 28.6 2.4 8.8 13.6 3.1 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 Cep57_MT_bd PF06657.13 ETO18064.1 - 3.2 8.3 17.2 1.1 9.7 1.7 3.1 1 1 2 3 3 3 0 Centrosome microtubule-binding domain of Cep57 TPR_MLP1_2 PF07926.12 ETO18064.1 - 3.3 7.8 27.3 13 5.9 20.8 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein XhlA PF10779.9 ETO18064.1 - 3.6 7.8 14.7 2.3 8.5 4.1 2.6 2 0 0 2 2 2 0 Haemolysin XhlA TcdA_TcdB PF12919.7 ETO18064.1 - 4.2 6.6 16.1 0.066 12.5 5.6 2.0 1 1 1 2 2 2 0 TcdA/TcdB catalytic glycosyltransferase domain Tho2 PF11262.8 ETO18064.1 - 4.3 6.4 19.7 1.8 7.7 6.4 2.1 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 KxDL PF10241.9 ETO18064.1 - 5 7.5 18.8 1.4 9.3 4.2 2.6 1 1 1 3 3 3 0 Uncharacterized conserved protein DUF2968 PF11180.8 ETO18064.1 - 5 6.7 22.8 6.9 6.3 11.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) DUF2120 PF09893.9 ETO18064.1 - 5.1 7.2 10.8 0.58 10.3 4.8 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) LMBR1 PF04791.16 ETO18064.1 - 7.6 5.3 12.8 8.6 5.1 12.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF724 PF05266.14 ETO18064.1 - 7.8 6.3 23.7 3.7 7.3 9.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) MbeD_MobD PF04899.12 ETO18064.1 - 8.3 6.6 13.4 2.8 8.1 5.2 3.3 1 1 2 3 3 3 0 MbeD/MobD like Ribosomal_S8e PF01201.22 ETO18065.1 - 5 7.3 13.1 13 6.0 13.1 1.7 1 0 0 1 1 1 0 Ribosomal protein S8e ADK PF00406.22 ETO18066.1 - 0.32 11.1 0.0 0.32 11.1 0.0 3.1 3 0 0 3 3 3 0 Adenylate kinase AAA_18 PF13238.6 ETO18066.1 - 1 9.9 0.0 1 9.9 0.0 4.6 4 1 1 5 5 5 0 AAA domain Hydin_ADK PF17213.3 ETO18066.1 - 1.1 9.6 0.0 1.1 9.6 0.0 4.6 3 1 1 5 5 5 0 Hydin Adenylate kinase-like domain AAA_17 PF13207.6 ETO18066.1 - 3 8.3 0.0 3 8.3 0.0 4.2 2 1 2 5 5 5 0 AAA domain Secretin_N_2 PF07655.13 ETO18066.1 - 6.2 7.4 17.2 38 4.9 17.2 2.4 1 0 0 1 1 1 0 Secretin N-terminal domain SRTM1 PF15872.5 ETO18067.1 - 6 7.1 7.4 5.3 7.2 2.5 2.5 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 Menin PF05053.13 ETO18068.1 - 0.99 7.7 8.5 1.2 7.4 8.5 1.1 1 0 0 1 1 1 0 Menin MscS_TM PF12794.7 ETO18069.1 - 0.018 13.9 0.8 0.021 13.7 0.8 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Vps51 PF08700.11 ETO18070.1 - 0.0044 17.1 10.2 0.012 15.7 1.0 2.9 1 1 1 2 2 2 2 Vps51/Vps67 Adenylsucc_synt PF00709.21 ETO18070.1 - 0.34 9.8 1.2 0.46 9.4 1.2 1.1 1 0 0 1 1 1 0 Adenylosuccinate synthetase Exonuc_VII_L PF02601.15 ETO18070.1 - 0.57 9.7 4.4 0.75 9.3 4.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Snapin_Pallidin PF14712.6 ETO18070.1 - 1.2 9.6 15.8 0.055 13.9 5.6 2.5 1 1 1 2 2 2 0 Snapin/Pallidin POC3_POC4 PF10448.9 ETO18071.1 - 0.032 14.2 1.4 0.16 12.0 0.0 2.1 2 0 0 2 2 2 0 20S proteasome chaperone assembly proteins 3 and 4 DUF3439 PF11921.8 ETO18071.1 - 0.066 13.2 4.0 0.11 12.4 4.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DP PF08781.10 ETO18071.1 - 0.086 12.7 0.7 0.16 11.8 0.7 1.4 1 0 0 1 1 1 0 Transcription factor DP Methyltransf_11 PF08241.12 ETO18072.1 - 1.5e-06 28.7 0.0 3.2e-06 27.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO18072.1 - 1.2e-05 25.2 0.0 1.7e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO18072.1 - 0.00088 19.1 0.0 0.0033 17.2 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO18072.1 - 0.001 18.5 0.0 0.0037 16.6 0.0 1.7 1 1 1 2 2 2 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ETO18072.1 - 0.0015 19.2 0.0 0.0029 18.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO18072.1 - 0.0028 18.3 0.0 0.0065 17.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain POX PF07526.11 ETO18073.1 - 0.018 15.6 4.0 0.029 15.0 4.0 1.3 1 0 0 1 1 1 0 Associated with HOX SSP160 PF06933.11 ETO18073.1 - 0.03 12.5 7.5 0.036 12.3 7.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 His_Phos_1 PF00300.22 ETO18073.1 - 0.17 11.6 0.0 0.43 10.2 0.0 1.7 2 0 0 2 2 2 0 Histidine phosphatase superfamily (branch 1) Macoilin PF09726.9 ETO18073.1 - 0.23 10.0 11.3 0.24 9.9 11.3 1.1 1 0 0 1 1 1 0 Macoilin family CLN3 PF02487.17 ETO18073.1 - 0.48 9.4 2.9 0.6 9.1 2.9 1.2 1 0 0 1 1 1 0 CLN3 protein DUF4614 PF15391.6 ETO18073.1 - 1.5 8.8 12.0 2.2 8.2 12.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Menin PF05053.13 ETO18073.1 - 2.3 6.5 10.1 2.8 6.2 10.1 1.1 1 0 0 1 1 1 0 Menin RLL PF10036.9 ETO18074.1 - 3.3 7.5 11.2 0.44 10.3 4.3 2.2 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein FH2 PF02181.23 ETO18075.1 - 5.1e-27 95.0 2.0 6.8e-27 94.6 2.0 1.2 1 0 0 1 1 1 1 Formin Homology 2 Domain L27_2 PF09045.10 ETO18076.1 - 0.05 13.6 0.3 0.079 12.9 0.3 1.4 1 0 0 1 1 1 0 L27_2 BSP_II PF05432.11 ETO18076.1 - 0.65 9.6 4.9 0.76 9.4 4.9 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) COPI_C PF06957.11 ETO18076.1 - 5.2 5.7 7.4 5.4 5.7 7.4 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus IBR PF01485.21 ETO18077.1 - 3.1e-18 65.7 45.9 1.3e-10 41.3 9.1 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 ETO18077.1 - 0.083 12.8 0.6 0.083 12.8 0.6 6.0 6 1 0 6 6 6 0 Zinc finger, C3HC4 type (RING finger) DUF4202 PF13875.6 ETO18078.1 - 0.061 13.2 0.3 0.092 12.6 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4202) zf-C2H2_2 PF12756.7 ETO18079.1 - 0.096 13.0 0.3 0.26 11.6 0.3 1.7 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) ApoO PF09769.9 ETO18080.1 - 0.15 12.0 1.5 0.36 10.8 1.5 1.7 1 0 0 1 1 1 0 Apolipoprotein O Fzo_mitofusin PF04799.13 ETO18080.1 - 5.1 6.6 10.7 4.6 6.8 8.1 2.1 1 1 1 2 2 2 0 fzo-like conserved region Prominin PF05478.11 ETO18080.1 - 5.8 4.7 15.9 8.4 4.2 15.9 1.2 1 0 0 1 1 1 0 Prominin Exo_endo_phos_2 PF14529.6 ETO18081.1 - 2.9e-09 36.8 0.9 7.5e-09 35.5 0.9 1.7 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase SMBP PF16785.5 ETO18083.1 - 0.034 14.4 0.0 0.051 13.8 0.0 1.3 1 0 0 1 1 1 0 Small metal-binding protein Orf78 PF06024.12 ETO18083.1 - 0.045 14.1 0.4 0.58 10.5 0.1 2.1 2 0 0 2 2 2 0 Orf78 (ac78) DUF2203 PF09969.9 ETO18084.1 - 0.03 15.0 10.2 3.4 8.4 0.2 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Baculo_PEP_C PF04513.12 ETO18084.1 - 0.059 13.4 5.4 1.8 8.6 0.6 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Peripla_BP_2 PF01497.18 ETO18084.1 - 0.16 11.5 0.3 0.29 10.6 0.3 1.3 1 0 0 1 1 1 0 Periplasmic binding protein DUF573 PF04504.14 ETO18084.1 - 0.18 12.5 5.1 0.23 12.1 2.7 2.6 1 1 0 2 2 2 0 Protein of unknown function, DUF573 Phage_GP20 PF06810.11 ETO18084.1 - 0.33 10.8 4.6 0.22 11.3 2.0 2.0 2 0 0 2 2 2 0 Phage minor structural protein GP20 Cytochrom_B562 PF07361.11 ETO18084.1 - 0.49 11.1 8.1 0.19 12.4 1.1 3.4 2 2 1 3 3 3 0 Cytochrome b562 DUF745 PF05335.13 ETO18084.1 - 0.99 9.1 8.7 0.59 9.8 5.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF745) Bacillus_HBL PF05791.11 ETO18084.1 - 1 9.2 5.9 8.6 6.2 0.6 2.9 2 1 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Snapin_Pallidin PF14712.6 ETO18084.1 - 1.1 9.7 12.3 0.76 10.2 2.7 3.2 2 1 2 4 4 4 0 Snapin/Pallidin HisKA_3 PF07730.13 ETO18084.1 - 2.2 8.9 9.2 48 4.6 1.0 4.0 4 0 0 4 4 4 0 Histidine kinase DUF1664 PF07889.12 ETO18084.1 - 2.4 8.2 9.9 3.8 7.6 1.4 3.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) TPR_MLP1_2 PF07926.12 ETO18084.1 - 3.1 7.9 18.6 0.22 11.6 8.0 3.1 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 ETO18084.1 - 3.3 7.9 19.3 0.12 12.6 6.4 2.8 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 DUF3453 PF11935.8 ETO18084.1 - 3.5 7.2 7.4 0.23 11.1 0.4 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3453) ACCA PF03255.14 ETO18084.1 - 3.7 7.4 8.4 1 9.2 2.7 2.4 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit FapA PF03961.13 ETO18084.1 - 4.1 5.9 14.6 7.3 5.1 4.6 2.9 2 1 1 3 3 3 0 Flagellar Assembly Protein A Cauli_AT PF03233.13 ETO18084.1 - 4.2 7.3 6.4 0.7 9.8 0.3 2.6 3 1 1 4 4 4 0 Aphid transmission protein Tweety PF04906.13 ETO18084.1 - 6.6 5.3 9.0 1.1 7.8 0.7 2.4 2 1 1 3 3 3 0 Tweety THOC7 PF05615.13 ETO18084.1 - 8.6 6.7 16.4 0.8 10.0 9.5 2.6 2 2 1 3 3 3 0 Tho complex subunit 7 GrpE PF01025.19 ETO18084.1 - 9.6 5.8 11.3 2.3 7.8 3.8 2.8 2 1 1 3 3 3 0 GrpE Phage_Gp23 PF10669.9 ETO18085.1 - 0.013 15.8 1.2 0.018 15.4 1.2 1.1 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Pkinase_Tyr PF07714.17 ETO18088.1 - 2.5e-48 164.7 0.0 1.5e-30 106.4 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO18088.1 - 1.4e-46 159.0 0.0 5.8e-46 157.0 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO18088.1 - 0.00023 20.1 0.0 0.00037 19.4 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO18088.1 - 0.028 13.8 0.1 0.045 13.1 0.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO18088.1 - 0.17 11.8 0.1 0.31 10.9 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF4162 PF13732.6 ETO18089.1 - 0.11 13.2 6.4 0.096 13.4 1.8 2.9 1 1 1 3 3 3 0 Domain of unknown function (DUF4162) DUF4763 PF15960.5 ETO18089.1 - 2 7.7 38.2 1.3 8.2 15.8 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4763) CT_C_D PF02682.16 ETO18089.1 - 7.1 6.3 5.4 3.5 7.3 0.8 2.4 2 1 1 3 3 3 0 Carboxyltransferase domain, subdomain C and D SH3BGR PF04908.15 ETO18090.1 - 0.057 13.6 0.2 0.13 12.4 0.1 1.6 2 0 0 2 2 2 0 SH3-binding, glutamic acid-rich protein 3-PAP PF12578.8 ETO18091.1 - 0.016 14.9 0.1 0.034 13.9 0.1 1.5 1 0 0 1 1 1 0 Myotubularin-associated protein MRI PF15325.6 ETO18091.1 - 0.89 10.7 5.3 1.8 9.7 5.3 1.4 1 0 0 1 1 1 0 Modulator of retrovirus infection CDKN3 PF05706.12 ETO18092.1 - 8.8e-09 35.2 0.1 1.5e-08 34.4 0.1 1.4 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase PF00102.27 ETO18092.1 - 1.9e-06 27.7 3.1 0.00032 20.3 1.5 2.9 1 1 1 2 2 2 2 Protein-tyrosine phosphatase DSPc PF00782.20 ETO18092.1 - 6.5e-06 26.0 0.6 2e-05 24.4 0.2 2.0 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO18092.1 - 0.00043 20.3 0.1 0.00065 19.7 0.1 1.4 1 1 0 1 1 1 1 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ETO18092.1 - 0.0045 17.1 0.0 0.011 15.9 0.0 1.6 1 1 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 ETO18092.1 - 0.035 13.7 0.1 0.05 13.2 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family G-alpha PF00503.20 ETO18094.1 - 3.6e-15 56.0 0.0 5.6e-15 55.3 0.0 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Rad17 PF03215.15 ETO18094.1 - 0.0009 19.2 0.0 0.0015 18.5 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 ETO18094.1 - 0.0018 18.7 0.0 0.002 18.5 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ETO18094.1 - 0.0072 16.8 0.1 0.0099 16.4 0.1 1.3 1 1 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 ETO18094.1 - 0.012 14.8 0.1 0.026 13.7 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain Mg_chelatase PF01078.21 ETO18094.1 - 0.013 14.9 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_23 PF13476.6 ETO18094.1 - 0.022 15.3 0.0 0.027 15.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO18094.1 - 0.023 15.1 0.0 0.06 13.7 0.0 1.7 2 0 0 2 2 2 0 RNA helicase AAA_29 PF13555.6 ETO18094.1 - 0.035 13.8 0.0 0.059 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA PF00004.29 ETO18094.1 - 0.039 14.4 0.0 0.06 13.8 0.0 1.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) PduV-EutP PF10662.9 ETO18094.1 - 0.04 13.7 0.2 0.1 12.3 0.1 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 ETO18094.1 - 0.054 13.4 0.1 0.079 12.9 0.1 1.5 1 1 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 ETO18094.1 - 0.056 13.5 0.0 0.079 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO18094.1 - 0.071 13.4 0.0 0.09 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ETO18094.1 - 0.079 13.2 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 ETO18094.1 - 0.1 12.4 0.0 0.1 12.4 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system CAP_GLY PF01302.25 ETO18095.1 - 7.2e-17 61.2 0.6 1.2e-16 60.5 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain ETRAMP PF09716.10 ETO18097.1 - 0.0026 17.8 6.4 0.0026 17.8 6.4 2.3 2 1 0 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) TssO PF17561.2 ETO18097.1 - 0.019 15.1 13.2 0.16 12.0 13.3 2.0 1 1 0 1 1 1 0 Type VI secretion system, TssO Ion_trans PF00520.31 ETO18097.1 - 0.026 13.7 0.6 0.029 13.6 0.6 1.1 1 0 0 1 1 1 0 Ion transport protein OATP PF03137.20 ETO18097.1 - 0.074 11.3 4.3 0.053 11.8 3.1 1.3 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Ctr PF04145.15 ETO18097.1 - 0.093 13.3 1.7 0.13 12.9 1.7 1.3 1 1 0 1 1 1 0 Ctr copper transporter family Ureide_permease PF07168.11 ETO18097.1 - 0.1 11.3 1.2 0.11 11.3 1.2 1.2 1 0 0 1 1 1 0 Ureide permease Comm PF15957.5 ETO18097.1 - 0.15 12.4 6.4 0.23 11.8 6.4 1.7 1 1 0 1 1 1 0 Commissureless CRA PF06589.11 ETO18097.1 - 0.31 11.1 15.6 0.38 10.9 13.4 1.9 1 1 1 2 2 2 0 Circumsporozoite-related antigen (CRA) O-antigen_lig PF13425.6 ETO18097.1 - 0.49 9.1 6.9 0.045 12.5 2.0 1.7 1 1 1 2 2 2 0 O-antigen ligase like membrane protein OAD_gamma PF04277.13 ETO18097.1 - 0.5 11.0 9.1 0.3 11.7 5.3 2.4 2 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Ac76 PF05814.11 ETO18097.1 - 0.59 10.2 10.0 0.12 12.4 4.3 2.4 2 1 0 2 2 2 0 Orf76 (Ac76) Ycf70 PF17382.2 ETO18097.1 - 2.3 8.7 7.3 0.58 10.6 2.3 2.1 2 0 0 2 2 2 0 Uncharacterized Ycf70-like SR-25 PF10500.9 ETO18097.1 - 5 6.7 17.5 0.55 9.8 10.2 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein NPR1_interact PF15699.5 ETO18097.1 - 6.8 7.4 13.0 13 6.4 4.0 2.2 1 1 0 2 2 2 0 NPR1 interacting RGS PF00615.19 ETO18098.1 - 0.0014 18.9 0.4 0.017 15.4 0.0 2.1 1 1 1 2 2 2 1 Regulator of G protein signaling domain WWE PF02825.20 ETO18098.1 - 0.087 13.4 0.1 0.17 12.5 0.1 1.5 1 0 0 1 1 1 0 WWE domain Glyco_tranf_2_4 PF13704.6 ETO18098.1 - 0.17 12.4 0.0 0.34 11.5 0.0 1.5 2 0 0 2 2 2 0 Glycosyl transferase family 2 Dynamin_N PF00350.23 ETO18099.1 - 3.4e-16 59.8 0.1 5.1e-16 59.2 0.1 1.3 1 0 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ETO18099.1 - 0.00032 20.7 0.1 0.005 16.9 0.1 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_15 PF13175.6 ETO18099.1 - 0.00077 19.3 4.1 0.00095 19.0 4.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ETO18099.1 - 0.022 14.6 0.4 0.048 13.5 0.4 1.6 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system GTP_EFTU PF00009.27 ETO18099.1 - 0.049 13.2 0.1 0.22 11.1 0.1 1.9 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain TniB PF05621.11 ETO18099.1 - 0.083 12.3 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ETO18099.1 - 0.097 13.2 0.2 0.16 12.5 0.2 1.4 1 1 0 1 1 1 0 ABC transporter Dynamin_M PF01031.20 ETO18100.1 - 1.9e-19 70.0 14.3 1.4e-12 47.4 7.5 2.4 2 0 0 2 2 2 2 Dynamin central region GED PF02212.18 ETO18100.1 - 1.4e-07 31.5 1.0 1.4e-07 31.5 1.0 2.8 2 0 0 2 2 2 1 Dynamin GTPase effector domain Peptidase_M75 PF09375.10 ETO18100.1 - 0.031 13.7 1.3 0.052 13.0 1.3 1.3 1 0 0 1 1 1 0 Imelysin CobU PF02283.16 ETO18100.1 - 0.14 11.7 0.5 0.36 10.4 0.5 1.7 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase GAGA_bind PF06217.12 ETO18100.1 - 0.27 11.5 3.7 0.51 10.6 3.7 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family baeRF_family3 PF18845.1 ETO18100.1 - 0.43 10.8 3.3 11 6.2 0.8 2.6 2 1 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 DUF3545 PF12065.8 ETO18100.1 - 1.2 9.2 8.5 0.55 10.3 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3545) Ank_2 PF12796.7 ETO18101.1 - 3.4e-26 91.6 0.3 2e-12 47.5 0.0 2.6 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO18101.1 - 5.7e-24 81.6 0.8 3.1e-05 24.0 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ETO18101.1 - 1.1e-22 80.1 5.1 4.8e-10 39.8 0.1 3.6 2 2 2 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO18101.1 - 1.1e-22 79.8 2.5 1.4e-08 34.8 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO18101.1 - 1.2e-21 76.1 0.4 4e-07 30.2 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat DUF249 PF03158.13 ETO18101.1 - 0.00028 20.6 2.5 0.3 10.8 0.4 2.9 2 2 1 3 3 3 2 Multigene family 530 protein Presenilin PF01080.17 ETO18101.1 - 0.17 10.6 3.0 0.22 10.3 3.0 1.1 1 0 0 1 1 1 0 Presenilin MscS_TM PF12794.7 ETO18101.1 - 0.33 9.8 2.1 0.61 8.9 2.1 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 XRCC4 PF06632.12 ETO18102.1 - 0.0002 20.4 1.9 0.00037 19.4 1.9 1.4 1 0 0 1 1 1 1 DNA double-strand break repair and V(D)J recombination protein XRCC4 MMR_HSR1_Xtn PF16897.5 ETO18102.1 - 0.049 13.6 0.5 0.049 13.6 0.5 3.0 1 1 0 2 2 2 0 C-terminal region of MMR_HSR1 domain WD40 PF00400.32 ETO18103.1 - 9.5e-09 35.8 2.0 3.2e-06 27.7 0.2 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat LRR_4 PF12799.7 ETO18104.1 - 1.3e-20 73.1 32.1 1.3e-09 38.1 0.3 8.4 3 2 4 8 8 8 6 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO18104.1 - 7.9e-15 54.4 23.8 7.7e-07 28.8 0.8 5.9 5 2 1 6 6 6 4 Leucine rich repeat LRR_9 PF14580.6 ETO18104.1 - 8.4e-09 35.2 15.5 4.6e-06 26.2 2.7 3.9 1 1 2 3 3 3 2 Leucine-rich repeat LRR_1 PF00560.33 ETO18104.1 - 0.028 14.9 27.3 24 6.0 0.0 9.2 10 1 0 10 10 10 0 Leucine Rich Repeat LRR_6 PF13516.6 ETO18104.1 - 0.037 14.1 12.4 3.1 8.1 0.0 6.4 6 1 1 7 7 7 0 Leucine Rich repeat Ribosomal_L27A PF00828.19 ETO18105.1 - 6.2e-20 72.2 0.0 8.2e-20 71.8 0.0 1.2 1 0 0 1 1 1 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ank_5 PF13857.6 ETO18106.1 - 0.00015 22.0 0.0 0.00036 20.8 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO18106.1 - 0.0028 18.2 0.0 0.0078 16.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO18106.1 - 0.0049 17.4 0.0 3.2 8.4 0.0 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) FTCD_C PF04961.12 ETO18106.1 - 1.8 8.3 4.0 20 4.9 0.6 2.4 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase PDDEXK_10 PF07788.11 ETO18107.1 - 0.0015 18.4 0.1 0.0026 17.6 0.1 1.4 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily BSD PF03909.17 ETO18108.1 - 2.5e-06 27.4 0.6 5.2e-06 26.4 0.6 1.6 1 0 0 1 1 1 1 BSD domain TFIIA PF03153.13 ETO18108.1 - 8.6e-05 22.7 24.8 0.00011 22.3 24.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Cwf_Cwc_15 PF04889.12 ETO18108.1 - 0.019 14.7 27.6 0.024 14.4 15.7 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein UBA_4 PF14555.6 ETO18109.1 - 4.5e-07 29.6 0.9 7e-07 29.0 0.9 1.4 1 0 0 1 1 1 1 UBA-like domain DNA_gyraseB PF00204.25 ETO18110.1 - 0.11 12.0 0.1 0.16 11.4 0.1 1.2 1 0 0 1 1 1 0 DNA gyrase B BUD22 PF09073.10 ETO18111.1 - 0.00072 19.0 1.9 0.00072 19.0 1.9 2.4 2 0 0 2 2 2 1 BUD22 CobT PF06213.12 ETO18111.1 - 0.0015 18.0 3.2 0.0032 16.9 3.2 1.6 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Cwf_Cwc_15 PF04889.12 ETO18111.1 - 0.0029 17.4 19.3 0.0029 17.4 19.3 3.1 4 0 0 4 4 4 1 Cwf15/Cwc15 cell cycle control protein Astro_capsid_p PF12226.8 ETO18111.1 - 0.019 14.2 7.0 0.036 13.2 7.0 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein TFB6 PF17110.5 ETO18111.1 - 0.45 10.3 6.6 0.043 13.6 1.5 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Connexin PF00029.19 ETO18111.1 - 0.92 9.2 3.9 5.7 6.6 0.0 2.6 2 0 0 2 2 2 0 Connexin DUF2076 PF09849.9 ETO18111.1 - 3 7.8 26.4 7.7 6.5 26.4 1.7 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF4820 PF16091.5 ETO18111.1 - 4.1 6.7 10.3 0.31 10.4 2.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) RRN3 PF05327.11 ETO18111.1 - 8.1 4.9 14.6 16 3.9 14.6 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ank_2 PF12796.7 ETO18112.1 - 0.0024 18.4 0.0 0.0059 17.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO18112.1 - 0.0029 18.1 0.1 0.028 15.0 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO18112.1 - 0.16 12.6 0.0 0.82 10.4 0.0 2.2 1 0 0 1 1 1 0 Ankyrin repeat ODV-E18 PF10717.9 ETO18112.1 - 0.45 10.4 2.2 0.9 9.5 2.2 1.5 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 CDC45 PF02724.14 ETO18113.1 - 0.0029 16.0 15.9 0.0036 15.7 15.9 1.2 1 0 0 1 1 1 1 CDC45-like protein GREB1 PF15782.5 ETO18113.1 - 0.34 8.0 19.2 0.41 7.7 19.2 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PNISR PF15996.5 ETO18113.1 - 1.2 9.4 18.3 2.5 8.4 18.3 1.6 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR STPPase_N PF16891.5 ETO18114.1 - 0.0075 16.7 0.4 0.012 16.0 0.4 1.3 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Bromodomain PF00439.25 ETO18115.1 - 1.7e-25 88.9 0.5 2.7e-25 88.2 0.5 1.4 1 0 0 1 1 1 1 Bromodomain AMP-binding_C_2 PF14535.6 ETO18115.1 - 0.072 13.4 0.4 1.2 9.5 0.0 2.2 1 1 1 2 2 2 0 AMP-binding enzyme C-terminal domain PRIMA1 PF16101.5 ETO18116.1 - 0.019 15.0 7.3 0.034 14.2 7.3 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 FAM176 PF14851.6 ETO18116.1 - 1.3 8.7 5.5 1.8 8.2 5.5 1.2 1 0 0 1 1 1 0 FAM176 family CAP_N PF01213.19 ETO18116.1 - 2.3 7.6 6.3 0.22 10.9 2.0 1.6 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal DNA_pol_phi PF04931.13 ETO18116.1 - 6.8 4.7 6.8 8.6 4.3 6.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi DHquinase_II PF01220.19 ETO18118.1 - 0.02 14.6 1.4 0.027 14.2 1.4 1.1 1 0 0 1 1 1 0 Dehydroquinase class II CLN3 PF02487.17 ETO18118.1 - 0.21 10.6 1.4 0.23 10.4 1.4 1.1 1 0 0 1 1 1 0 CLN3 protein FmiP_Thoc5 PF09766.9 ETO18119.1 - 0.00074 18.9 1.0 0.001 18.4 1.0 1.1 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 5TM-5TMR_LYT PF07694.12 ETO18119.1 - 0.0011 18.5 1.3 0.0026 17.3 1.3 1.6 1 0 0 1 1 1 1 5TMR of 5TMR-LYT SfLAP PF11139.8 ETO18119.1 - 0.027 13.9 1.9 3.2 7.1 0.2 2.3 2 0 0 2 2 2 0 Sap, sulfolipid-1-addressing protein SpoIIIAH PF12685.7 ETO18119.1 - 0.028 14.3 7.9 0.026 14.4 5.4 1.8 2 0 0 2 2 2 0 SpoIIIAH-like protein Apc15p PF05841.11 ETO18119.1 - 0.031 15.1 10.7 0.052 14.4 10.7 1.3 1 0 0 1 1 1 0 Apc15p protein DUF4834 PF16118.5 ETO18119.1 - 0.065 14.2 2.0 0.21 12.5 2.0 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Phage_holin_3_3 PF16083.5 ETO18119.1 - 0.075 13.1 0.3 0.075 13.1 0.3 2.4 3 1 0 3 3 3 0 LydA holin phage, holin superfamily III NST1 PF13945.6 ETO18119.1 - 3.1 7.9 19.0 5.1 7.2 19.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator MerC PF03203.14 ETO18119.1 - 4.1 7.9 10.6 0.52 10.8 3.9 2.6 2 1 1 3 3 3 0 MerC mercury resistance protein G-alpha PF00503.20 ETO18120.1 - 7.2e-27 94.5 0.3 8.7e-27 94.2 0.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO18120.1 - 4e-08 32.9 0.3 7.4e-08 32.0 0.3 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family SAM_2 PF07647.17 ETO18121.1 - 0.00014 21.9 0.0 0.00026 21.0 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO18121.1 - 0.018 15.5 0.0 0.035 14.6 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) MIB_HERC2 PF06701.13 ETO18122.1 - 1.8e-21 76.1 5.7 1.8e-21 76.1 5.7 2.9 3 0 0 3 3 3 1 Mib_herc2 T2SSF PF00482.23 ETO18122.1 - 0.13 12.2 0.0 0.27 11.2 0.0 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F Ank_2 PF12796.7 ETO18124.1 - 2.5e-05 24.8 0.0 0.037 14.6 0.0 3.1 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ETO18124.1 - 0.0092 16.4 0.0 12 6.5 0.0 3.8 5 0 0 5 5 5 1 Ankyrin repeat Ank_4 PF13637.6 ETO18124.1 - 0.0099 16.4 0.0 0.05 14.2 0.0 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO18124.1 - 0.014 15.7 0.1 9.8 6.6 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeats (many copies) ABA_GPCR PF12430.8 ETO18124.1 - 0.02 14.7 0.1 0.087 12.6 0.1 1.8 1 1 0 1 1 1 0 Abscisic acid G-protein coupled receptor Ank_3 PF13606.6 ETO18124.1 - 0.056 14.0 1.0 44 5.1 0.0 4.1 5 0 0 5 5 5 0 Ankyrin repeat TPR_1 PF00515.28 ETO18125.1 - 7.5e-15 54.0 8.9 2.7e-07 30.1 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18125.1 - 1.1e-14 53.2 12.2 1.5e-06 27.9 0.1 5.0 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18125.1 - 4.7e-13 48.6 3.6 2e-05 24.2 0.5 3.9 4 1 1 5 5 5 3 TPR repeat TPR_19 PF14559.6 ETO18125.1 - 3.9e-11 43.3 0.0 9.8e-06 26.0 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO18125.1 - 6e-11 42.3 0.0 3.7e-07 30.2 0.0 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18125.1 - 2.4e-10 39.8 6.7 2.5e-05 24.1 0.1 4.6 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO18125.1 - 2.5e-08 34.4 0.5 2.3e-05 25.0 0.0 3.4 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO18125.1 - 4.8e-08 32.8 1.0 0.0052 17.1 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO18125.1 - 4.6e-07 30.0 7.8 0.014 15.7 0.6 4.1 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18125.1 - 8.3e-07 28.6 1.3 0.00016 21.4 0.0 3.8 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18125.1 - 2e-06 28.1 0.2 0.0018 18.9 0.0 3.8 2 2 2 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18125.1 - 3.9e-06 27.1 1.7 0.018 15.7 0.0 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO18125.1 - 9.7e-06 25.6 6.1 0.0025 17.8 0.3 3.4 3 1 1 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat ANAPC3 PF12895.7 ETO18125.1 - 2.4e-05 24.4 0.6 2.4e-05 24.4 0.6 2.8 1 1 2 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETO18125.1 - 0.0052 17.1 0.2 0.38 11.1 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 ETO18125.1 - 0.018 15.5 0.4 3.5 8.1 0.1 2.3 1 1 0 2 2 2 0 Bacterial transcriptional activator domain MIT PF04212.18 ETO18125.1 - 0.024 14.7 0.5 12 6.0 0.1 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO18125.1 - 0.091 12.2 0.0 0.51 9.8 0.0 2.1 2 0 0 2 2 2 0 SHNi-TPR HSP90 PF00183.18 ETO18126.1 - 0.062 12.2 0.1 0.07 12.0 0.1 1.0 1 0 0 1 1 1 0 Hsp90 protein ClpB_D2-small PF10431.9 ETO18127.1 - 6.5e-09 35.7 0.5 1.1e-08 35.0 0.4 1.4 1 1 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein EF-hand_6 PF13405.6 ETO18128.1 - 5e-10 38.5 4.0 0.00088 19.0 0.2 5.5 5 0 0 5 5 5 2 EF-hand domain EF-hand_7 PF13499.6 ETO18128.1 - 3.9e-09 36.8 6.4 6.8e-08 32.8 1.1 3.8 3 1 1 4 4 4 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO18128.1 - 6.6e-08 31.6 5.4 1.2e-05 24.5 0.2 5.2 5 0 0 5 5 5 1 EF hand EF-hand_5 PF13202.6 ETO18128.1 - 6.4e-07 28.6 4.8 3.2e-06 26.4 0.6 3.3 3 0 0 3 3 3 1 EF hand EF-hand_8 PF13833.6 ETO18128.1 - 3.2e-05 23.7 4.2 0.0014 18.5 0.1 3.7 4 0 0 4 4 4 1 EF-hand domain pair GPHH PF16905.5 ETO18128.1 - 0.076 12.8 0.0 2.8 7.8 0.0 2.5 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Pkinase PF00069.25 ETO18129.1 - 1.2e-09 38.0 0.1 2.9e-08 33.4 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18129.1 - 1e-05 25.0 0.0 1.6e-05 24.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Med13_C PF06333.12 ETO18129.1 - 0.012 14.9 0.2 0.013 14.8 0.2 1.1 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain O-antigen_lig PF13425.6 ETO18129.1 - 0.56 8.9 1.3 0.74 8.5 1.3 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TPR_19 PF14559.6 ETO18132.1 - 0.00064 20.2 0.0 0.0012 19.3 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Atrophin-1 PF03154.15 ETO18132.1 - 0.0027 16.1 6.5 0.0028 16.0 6.5 1.1 1 0 0 1 1 1 1 Atrophin-1 family Sigma70_ner PF04546.13 ETO18132.1 - 0.0064 16.4 5.9 0.0066 16.3 5.9 1.2 1 0 0 1 1 1 1 Sigma-70, non-essential region ANAPC3 PF12895.7 ETO18132.1 - 0.033 14.4 0.1 0.062 13.5 0.1 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Presenilin PF01080.17 ETO18132.1 - 0.041 12.7 5.0 0.046 12.5 5.0 1.1 1 0 0 1 1 1 0 Presenilin Phage_Gp23 PF10669.9 ETO18132.1 - 0.19 12.1 11.0 0.28 11.5 11.0 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) SID-1_RNA_chan PF13965.6 ETO18132.1 - 0.2 10.0 2.4 0.21 9.9 2.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 ETO18132.1 - 0.25 10.5 5.3 0.28 10.4 5.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Serinc PF03348.15 ETO18132.1 - 0.28 10.1 1.5 0.31 9.9 1.5 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF3915 PF13054.6 ETO18132.1 - 0.5 10.3 11.9 0.36 10.8 10.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) Connexin PF00029.19 ETO18132.1 - 0.58 9.9 4.8 0.59 9.8 4.8 1.2 1 0 0 1 1 1 0 Connexin DUF4820 PF16091.5 ETO18132.1 - 0.7 9.2 5.7 0.76 9.1 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RR_TM4-6 PF06459.12 ETO18132.1 - 0.74 9.6 11.8 0.84 9.4 11.8 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 ETO18132.1 - 0.77 10.1 17.1 0.93 9.8 17.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Paramyxo_ncap PF00973.19 ETO18132.1 - 0.78 8.6 5.1 0.87 8.4 5.1 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein CPSF100_C PF13299.6 ETO18132.1 - 1.7 8.8 9.1 2.1 8.5 9.1 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RP-C_C PF11800.8 ETO18132.1 - 2 8.5 7.9 2.3 8.3 7.9 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Cytomega_UL84 PF06284.11 ETO18132.1 - 2.2 6.6 10.0 2.6 6.4 10.0 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein CLN3 PF02487.17 ETO18132.1 - 2.5 7.1 3.8 2.4 7.1 3.8 1.1 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 ETO18132.1 - 2.6 6.3 11.1 2.7 6.2 11.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 ETO18132.1 - 3.6 6.3 13.0 4.3 6.0 13.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sec62 PF03839.16 ETO18132.1 - 5.7 6.4 9.1 6.9 6.1 9.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Ferlin_C PF16165.5 ETO18132.1 - 6.2 6.7 9.3 8 6.4 9.3 1.2 1 0 0 1 1 1 0 Ferlin C-terminus Glyco_transf_34 PF05637.12 ETO18133.1 - 0.019 14.7 6.1 0.91 9.2 1.1 2.6 2 0 0 2 2 2 0 galactosyl transferase GMA12/MNN10 family Sec62 PF03839.16 ETO18134.1 - 0.0089 15.6 7.8 0.011 15.3 7.8 1.1 1 0 0 1 1 1 1 Translocation protein Sec62 FAM60A PF15396.6 ETO18134.1 - 0.014 15.4 10.3 0.016 15.3 10.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Apis_Csd PF11671.8 ETO18134.1 - 0.039 14.0 22.1 0.054 13.5 22.1 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein Presenilin PF01080.17 ETO18134.1 - 0.065 12.0 13.8 0.067 11.9 13.8 1.1 1 0 0 1 1 1 0 Presenilin Dsh_C PF12316.8 ETO18134.1 - 0.087 13.2 2.6 0.1 13.0 2.6 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Neur_chan_memb PF02932.16 ETO18134.1 - 0.088 12.9 5.8 0.12 12.4 5.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.13 ETO18134.1 - 0.092 13.4 5.6 0.11 13.2 5.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PNISR PF15996.5 ETO18134.1 - 0.16 12.2 19.9 0.21 11.8 19.9 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR HCO3_cotransp PF00955.21 ETO18134.1 - 0.17 10.6 3.7 0.19 10.5 3.7 1.1 1 0 0 1 1 1 0 HCO3- transporter family Hydin_ADK PF17213.3 ETO18134.1 - 0.7 10.1 7.3 0.85 9.9 7.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Secretin_N_2 PF07655.13 ETO18134.1 - 1.1 9.9 18.8 1.6 9.3 18.8 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain NINJA_B PF16136.5 ETO18134.1 - 1.4 9.3 17.2 0.71 10.3 15.4 1.4 1 1 0 1 1 1 0 Putative nuclear localisation signal DUF4746 PF15928.5 ETO18134.1 - 1.4 8.3 12.1 1.6 8.0 12.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Menin PF05053.13 ETO18134.1 - 1.5 7.1 12.5 1.6 7.0 12.5 1.1 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 ETO18134.1 - 3.9 6.4 18.7 4.1 6.3 18.7 1.0 1 0 0 1 1 1 0 Solute carrier family 12 DUF3807 PF12720.7 ETO18134.1 - 4.4 7.5 22.4 5 7.4 22.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) MFAP1 PF06991.11 ETO18134.1 - 5.1 6.9 23.5 0.33 10.8 17.4 1.7 1 1 1 2 2 2 0 Microfibril-associated/Pre-mRNA processing MAP7 PF05672.11 ETO18134.1 - 5.3 6.7 27.6 7.1 6.3 27.6 1.1 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Otopetrin PF03189.13 ETO18134.1 - 5.5 5.7 6.7 6.4 5.5 6.7 1.3 1 0 0 1 1 1 0 Otopetrin Cellulose_synt PF03552.14 ETO18134.1 - 6 5.2 6.3 6 5.2 6.3 1.0 1 0 0 1 1 1 0 Cellulose synthase Pannexin_like PF12534.8 ETO18134.1 - 6.1 5.8 11.9 7.6 5.5 11.9 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Gti1_Pac2 PF09729.9 ETO18134.1 - 8.5 6.4 20.3 11 6.0 20.3 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Zip PF02535.22 ETO18134.1 - 8.6 5.5 8.8 9.6 5.3 8.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Nop25 PF09805.9 ETO18134.1 - 9.2 6.7 23.2 11 6.5 23.2 1.1 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Mucin PF01456.17 ETO18135.1 - 0.0025 17.8 2.5 0.0027 17.7 1.4 1.6 2 0 0 2 2 2 1 Mucin-like glycoprotein PH PF00169.29 ETO18135.1 - 0.033 14.7 0.7 0.06 13.9 0.5 1.8 1 1 0 1 1 1 0 PH domain Strumpellin PF10266.9 ETO18136.1 - 4.6e-126 422.0 6.7 5.5e-126 421.8 6.7 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin DNA_pol_B_exo2 PF10108.9 ETO18136.1 - 0.028 14.1 1.1 0.052 13.2 0.3 1.8 2 1 0 2 2 2 0 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB Kelch_6 PF13964.6 ETO18137.1 - 0.015 15.6 0.1 0.029 14.6 0.1 1.5 1 0 0 1 1 1 0 Kelch motif CAP_GLY PF01302.25 ETO18138.1 - 7.7e-13 48.3 0.4 1.4e-12 47.5 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain SAPS PF04499.15 ETO18138.1 - 0.92 8.2 5.0 0.97 8.1 5.0 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NOA36 PF06524.12 ETO18138.1 - 1.4 8.2 10.2 1.7 7.9 10.2 1.1 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETO18138.1 - 2.2 7.8 10.6 2.7 7.5 10.6 1.1 1 0 0 1 1 1 0 PPP4R2 DUF2722 PF10846.8 ETO18139.1 - 0.26 10.2 18.6 0.15 11.0 11.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) NOA36 PF06524.12 ETO18139.1 - 0.44 9.8 25.0 0.69 9.2 25.0 1.2 1 0 0 1 1 1 0 NOA36 protein PI3K_1B_p101 PF10486.9 ETO18139.1 - 0.64 7.7 3.9 0.97 7.1 3.9 1.4 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 ETO18139.1 - 0.64 8.2 14.1 1.2 7.4 14.1 1.4 1 0 0 1 1 1 0 CDC45-like protein PPP4R2 PF09184.11 ETO18139.1 - 1.1 8.8 19.7 2 7.9 19.7 1.4 1 0 0 1 1 1 0 PPP4R2 DNA_pol_phi PF04931.13 ETO18139.1 - 1.7 6.7 33.1 0.97 7.5 28.0 2.1 2 0 0 2 2 2 0 DNA polymerase phi DUF4637 PF15470.6 ETO18139.1 - 2.4 7.9 10.8 6.2 6.5 10.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TFIIF_alpha PF05793.12 ETO18139.1 - 2.9 6.4 21.3 4.1 5.9 21.3 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Astro_capsid_p PF12226.8 ETO18139.1 - 3 6.9 18.9 5 6.2 18.9 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein GCIP PF13324.6 ETO18139.1 - 4.8 6.7 12.2 11 5.5 12.2 1.6 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RNA_pol_3_Rpc31 PF11705.8 ETO18139.1 - 5.9 7.1 25.9 12 6.1 25.9 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.14 ETO18139.1 - 6.7 6.4 15.4 14 5.4 15.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NPR3 PF03666.13 ETO18139.1 - 9.6 4.9 12.1 19 3.9 0.1 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 WD40 PF00400.32 ETO18140.1 - 5.6e-21 74.5 22.2 5e-05 24.0 0.5 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18140.1 - 1.7e-05 25.0 0.0 0.22 11.9 0.1 4.1 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18140.1 - 0.0017 17.1 0.2 0.038 12.6 0.0 2.4 2 0 0 2 2 2 1 Nucleoporin Nup120/160 DUF620 PF04788.12 ETO18140.1 - 0.012 15.0 0.0 0.27 10.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF620) GPS2_interact PF15784.5 ETO18140.1 - 0.097 13.1 2.5 0.21 12.0 2.5 1.5 1 0 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain VPS13_mid_rpt PF16910.5 ETO18142.1 - 8.6e-15 54.8 20.2 2.1e-07 30.6 0.4 6.7 6 1 1 7 7 7 4 Repeating coiled region of VPS13 UB2H PF14814.6 ETO18143.1 - 0.0055 16.7 0.0 0.014 15.4 0.0 1.8 1 0 0 1 1 1 1 Bifunctional transglycosylase second domain RD3 PF14473.6 ETO18143.1 - 0.0056 16.5 1.1 0.0097 15.8 1.1 1.4 1 0 0 1 1 1 1 RD3 protein DIT1_PvcA PF05141.12 ETO18143.1 - 0.014 14.9 1.2 0.018 14.5 1.2 1.2 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein Tox-SGS PF15651.6 ETO18143.1 - 0.048 13.9 0.0 0.089 13.0 0.0 1.4 1 0 0 1 1 1 0 Salivary glad secreted protein domain toxin DUF2004 PF09406.10 ETO18143.1 - 0.068 13.5 0.9 0.13 12.6 0.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2004) SNARE_assoc PF09335.11 ETO18144.1 - 3.5e-07 30.7 1.6 0.0016 18.9 0.2 2.5 2 1 0 2 2 2 2 SNARE associated Golgi protein DUF4392 PF14336.6 ETO18145.1 - 8.5e-15 55.0 0.1 9.9e-15 54.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4392) KA1 PF02149.19 ETO18146.1 - 0.00085 19.1 0.1 0.0024 17.6 0.1 1.8 1 1 0 1 1 1 1 Kinase associated domain 1 G-alpha PF00503.20 ETO18147.1 - 1.1e-20 74.1 15.9 7.6e-20 71.4 15.9 2.1 1 1 0 1 1 1 1 G-protein alpha subunit DUF755 PF05501.11 ETO18147.1 - 0.025 14.9 6.1 0.025 14.9 6.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF755) DUF3915 PF13054.6 ETO18148.1 - 0.16 11.9 13.3 0.17 11.9 1.7 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Baculo_PP31 PF05311.11 ETO18150.1 - 0.0029 17.2 0.8 0.0029 17.2 0.8 1.7 2 0 0 2 2 2 1 Baculovirus 33KDa late protein (PP31) Arm PF00514.23 ETO18151.1 - 9.3e-05 22.3 0.1 1.9 8.6 0.0 5.1 5 1 0 5 5 5 3 Armadillo/beta-catenin-like repeat GAS PF13851.6 ETO18152.1 - 1.9e-34 118.8 36.2 1.9e-34 118.8 36.2 3.3 2 2 0 2 2 2 1 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 ETO18152.1 - 0.025 14.8 5.4 0.025 14.8 5.4 4.9 1 1 5 6 6 6 0 TATA element modulatory factor 1 TATA binding Uso1_p115_C PF04871.13 ETO18152.1 - 0.043 14.2 2.0 0.043 14.2 2.0 4.2 1 1 3 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2120 PF09893.9 ETO18152.1 - 6.3 6.9 12.1 0.5 10.5 1.1 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) DUF4047 PF13256.6 ETO18153.1 - 0.031 14.5 5.6 0.044 14.0 5.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) Spidroin_N PF16763.5 ETO18153.1 - 0.065 13.3 0.1 0.12 12.4 0.1 1.4 1 0 0 1 1 1 0 Major ampullate spidroin 1, spider silk protein 1, N-term CENP-Q PF13094.6 ETO18153.1 - 0.08 13.1 8.4 0.11 12.7 8.4 1.2 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit MapZ_EC1 PF18041.1 ETO18153.1 - 0.86 9.8 10.5 0.038 14.2 2.4 2.5 2 1 0 2 2 2 0 MapZ extracellular domain 1 DUF724 PF05266.14 ETO18154.1 - 0.011 15.6 7.7 0.011 15.6 7.7 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF724) SHE3 PF17078.5 ETO18154.1 - 3.9 7.1 26.9 3.3 7.4 11.8 2.5 1 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 YabA PF06156.13 ETO18154.1 - 5.4 7.7 21.5 3.6 8.3 5.0 3.3 3 1 0 3 3 3 0 Initiation control protein YabA HMMR_N PF15905.5 ETO18154.1 - 6.1 6.2 30.4 0.38 10.2 13.1 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Bromodomain PF00439.25 ETO18155.1 - 3e-22 78.5 0.0 4.9e-22 77.8 0.0 1.4 1 0 0 1 1 1 1 Bromodomain CCDC53 PF10152.9 ETO18155.1 - 0.0057 17.1 5.3 0.0078 16.6 5.3 1.2 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex Presenilin PF01080.17 ETO18155.1 - 0.006 15.4 4.6 0.0066 15.3 4.6 1.2 1 0 0 1 1 1 1 Presenilin MMU163 PF17119.5 ETO18155.1 - 0.02 14.0 8.1 0.03 13.5 8.1 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis DDHD PF02862.17 ETO18155.1 - 0.058 13.6 2.2 0.069 13.3 2.2 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 ETO18155.1 - 0.14 12.0 12.6 0.19 11.5 12.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Coilin_N PF15862.5 ETO18155.1 - 0.15 11.8 12.2 0.25 11.1 12.2 1.3 1 0 0 1 1 1 0 Coilin N-terminus TERB2 PF15101.6 ETO18155.1 - 0.23 11.5 7.3 0.33 11.0 7.3 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RP-C_C PF11800.8 ETO18155.1 - 0.28 11.2 9.2 0.38 10.8 9.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Roughex PF06020.11 ETO18155.1 - 0.73 8.9 7.2 0.93 8.5 7.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein AIF_C PF14721.6 ETO18155.1 - 0.85 10.0 5.8 1.8 8.9 5.8 1.6 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term NPR3 PF03666.13 ETO18155.1 - 0.98 8.1 10.5 1.2 7.8 10.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 ETO18155.1 - 1 8.2 6.4 1.4 7.8 6.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF5427 PF10310.9 ETO18155.1 - 1.3 7.9 15.4 1.7 7.5 15.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Gti1_Pac2 PF09729.9 ETO18155.1 - 1.8 8.6 11.6 3.2 7.8 11.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4746 PF15928.5 ETO18155.1 - 1.9 7.8 11.9 2.6 7.4 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4407 PF14362.6 ETO18155.1 - 2.2 7.6 13.0 3.2 7.0 13.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RRN3 PF05327.11 ETO18155.1 - 2.2 6.7 10.5 0.15 10.5 3.8 1.9 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Peptidase_U57 PF05582.12 ETO18155.1 - 2.2 7.5 8.9 3.2 6.9 8.9 1.2 1 0 0 1 1 1 0 YabG peptidase U57 Paramyxo_ncap PF00973.19 ETO18155.1 - 8.5 5.2 9.1 11 4.8 9.1 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FAM76 PF16046.5 ETO18156.1 - 0.019 14.3 0.2 0.027 13.8 0.2 1.1 1 0 0 1 1 1 0 FAM76 protein LapA_dom PF06305.11 ETO18156.1 - 0.15 11.9 5.1 4.1 7.3 0.0 3.4 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Vfa1 PF08432.10 ETO18157.1 - 0.012 15.9 16.9 0.018 15.4 16.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CCSAP PF15748.5 ETO18157.1 - 0.16 12.1 18.7 0.17 12.0 18.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated DDHD PF02862.17 ETO18157.1 - 0.27 11.4 11.5 0.34 11.0 11.5 1.1 1 0 0 1 1 1 0 DDHD domain DUF5523 PF17661.1 ETO18157.1 - 0.34 10.5 20.7 0.41 10.3 20.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) RRN3 PF05327.11 ETO18157.1 - 1.6 7.2 12.6 1.8 7.0 12.6 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 V_ATPase_I PF01496.19 ETO18157.1 - 1.7 6.4 11.1 2 6.2 11.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4746 PF15928.5 ETO18157.1 - 1.9 7.9 15.2 2.4 7.5 15.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Neur_chan_memb PF02932.16 ETO18157.1 - 2.1 8.4 10.7 2.5 8.1 10.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Transformer PF06495.11 ETO18157.1 - 2.7 8.1 6.6 14 5.7 4.3 2.0 1 1 1 2 2 2 0 Fruit fly transformer protein DUF5427 PF10310.9 ETO18157.1 - 3.3 6.5 21.0 4 6.3 21.0 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) SLC12 PF03522.15 ETO18157.1 - 4.3 6.3 17.5 4.9 6.1 17.5 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 ETO18157.1 - 4.6 6.0 5.7 5.3 5.9 5.7 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) TCP PF03634.13 ETO18157.1 - 6.6 7.3 19.0 8.5 6.9 19.0 1.2 1 0 0 1 1 1 0 TCP family transcription factor Mlh1_C PF16413.5 ETO18157.1 - 7.3 5.9 12.4 12 5.2 12.4 1.4 1 1 0 1 1 1 0 DNA mismatch repair protein Mlh1 C-terminus DUF812 PF05667.11 ETO18158.1 - 0.18 10.7 2.9 0.19 10.6 2.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) Orf78 PF06024.12 ETO18158.1 - 3.8 7.9 8.1 8.7 6.7 8.1 1.7 1 1 0 1 1 1 0 Orf78 (ac78) Menin PF05053.13 ETO18158.1 - 3.9 5.7 13.4 4.4 5.5 13.4 1.1 1 0 0 1 1 1 0 Menin FGF PF00167.18 ETO18159.1 - 0.00015 21.9 1.1 0.28 11.3 0.1 2.7 2 1 0 2 2 2 2 Fibroblast growth factor RicinB_lectin_2 PF14200.6 ETO18159.1 - 0.00019 22.1 3.7 0.0097 16.6 0.1 3.3 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Fascin PF06268.13 ETO18159.1 - 0.026 14.7 0.2 9.5 6.5 0.1 3.1 2 1 1 3 3 3 0 Fascin domain CCSAP PF15748.5 ETO18159.1 - 2.5 8.2 7.8 4.2 7.5 7.8 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PCI PF01399.27 ETO18160.1 - 7.5e-06 26.4 0.3 1.6e-05 25.3 0.3 1.6 1 0 0 1 1 1 1 PCI domain PLN_propep PF16485.5 ETO18160.1 - 0.0018 17.9 0.0 0.32 10.7 0.0 2.5 2 0 0 2 2 2 2 Protealysin propeptide ATP-synt_G PF04718.15 ETO18160.1 - 0.11 13.4 0.2 0.77 10.6 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ATP synthase g subunit UPF0223 PF05256.12 ETO18160.1 - 0.15 12.4 1.1 0.57 10.6 0.2 2.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0223) Pex14_N PF04695.13 ETO18161.1 - 2e-05 25.3 0.6 2.7e-05 24.9 0.6 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region EF-hand_7 PF13499.6 ETO18162.1 - 3.7e-07 30.5 0.0 8.6e-07 29.3 0.0 1.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO18162.1 - 5.6e-07 28.7 0.1 0.046 13.3 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO18162.1 - 2.7e-06 27.1 0.1 0.0013 18.5 0.0 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO18162.1 - 8.8e-06 25.3 0.2 0.17 11.9 0.0 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO18162.1 - 0.011 15.2 0.3 1.3 8.6 0.1 2.4 2 0 0 2 2 2 0 EF hand EF-hand_4 PF12763.7 ETO18162.1 - 0.072 13.1 0.1 4.2 7.4 0.0 2.1 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand Kelch_6 PF13964.6 ETO18163.1 - 2.2e-10 40.4 0.5 2.1e-05 24.6 0.0 3.9 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO18163.1 - 9.5e-10 37.9 1.1 0.00079 19.0 0.2 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO18163.1 - 0.012 15.9 0.0 0.45 10.9 0.0 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO18163.1 - 0.1 12.6 1.7 9.2 6.4 0.8 3.3 3 1 0 3 3 3 0 Kelch motif Sigma_reg_N PF13800.6 ETO18165.1 - 0.8 10.0 3.1 9.9 6.5 0.0 2.7 2 1 0 3 3 3 0 Sigma factor regulator N-terminal GspL_C PF12693.7 ETO18165.1 - 1.4 8.7 3.4 3.1 7.6 0.4 2.6 3 0 0 3 3 3 0 GspL periplasmic domain DnaJ_C PF01556.18 ETO18167.1 - 9.1e-15 55.0 2.4 1.2e-14 54.7 0.9 1.7 1 1 1 2 2 2 1 DnaJ C terminal domain PTRF_SDPR PF15237.6 ETO18167.1 - 0.0021 17.7 4.3 0.0027 17.4 4.3 1.1 1 0 0 1 1 1 1 PTRF/SDPR family DUF4746 PF15928.5 ETO18167.1 - 0.046 13.1 5.7 0.048 13.1 5.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Spt20 PF12090.8 ETO18168.1 - 0.12 11.9 17.3 0.061 12.9 15.3 1.6 2 0 0 2 2 2 0 Spt20 family Maf1 PF09174.10 ETO18168.1 - 0.2 11.8 9.4 0.35 11.0 0.0 2.3 2 1 0 2 2 2 0 Maf1 regulator UPF0560 PF10577.9 ETO18168.1 - 0.69 8.3 9.6 0.86 8.0 9.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Roughex PF06020.11 ETO18168.1 - 1.3 8.1 5.3 1.5 7.9 5.3 1.2 1 0 0 1 1 1 0 Drosophila roughex protein PAT1 PF09770.9 ETO18168.1 - 2.4 6.3 14.3 2.6 6.2 14.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ras PF00071.22 ETO18169.1 - 5.8e-07 29.3 0.0 9.9e-07 28.5 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO18169.1 - 1.6e-06 28.3 0.0 1.6e-06 28.3 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase DUF4551 PF15087.6 ETO18169.1 - 0.014 14.3 3.1 0.021 13.7 3.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) SRPRB PF09439.10 ETO18169.1 - 0.025 14.0 0.0 0.056 12.9 0.0 1.6 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 ETO18169.1 - 0.055 12.9 0.2 0.72 9.2 0.0 2.5 2 1 1 3 3 3 0 Bacterial TniB protein Zip PF02535.22 ETO18169.1 - 1.5 8.0 6.4 0.68 9.1 1.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter NPR3 PF03666.13 ETO18169.1 - 5.4 5.7 15.9 17 4.1 11.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Gti1_Pac2 PF09729.9 ETO18169.1 - 9.2 6.3 10.1 5.2 7.1 6.2 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family SRP68 PF16969.5 ETO18171.1 - 8.3e-11 41.6 13.9 1.1e-07 31.3 9.7 3.0 1 1 0 2 2 2 2 RNA-binding signal recognition particle 68 Secretin_N_2 PF07655.13 ETO18171.1 - 9.5 6.8 8.1 0.99 10.0 1.4 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Cullin PF00888.22 ETO18172.1 - 9.4e-66 222.7 2.2 1e-65 222.6 2.2 1.0 1 0 0 1 1 1 1 Cullin family Med15_fungi PF05397.12 ETO18172.1 - 0.057 13.7 0.1 0.13 12.5 0.1 1.6 1 0 0 1 1 1 0 Mediator complex subunit 15 ACR_tran PF00873.19 ETO18173.1 - 0.0095 13.6 0.4 0.014 13.1 0.4 1.2 1 0 0 1 1 1 1 AcrB/AcrD/AcrF family DUF3323 PF11796.8 ETO18173.1 - 0.014 15.3 0.2 0.019 14.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function N-terminus (DUF3323) NYD-SP28 PF14772.6 ETO18173.1 - 0.078 13.0 3.7 0.18 11.8 3.7 1.6 1 0 0 1 1 1 0 Sperm tail DNA_pol3_beta PF00712.19 ETO18174.1 - 0.036 14.2 1.0 0.062 13.4 0.4 1.7 1 1 1 2 2 2 0 DNA polymerase III beta subunit, N-terminal domain Lectin_N PF03954.14 ETO18174.1 - 0.15 11.8 4.3 0.13 12.0 3.4 1.4 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF2207 PF09972.9 ETO18174.1 - 0.21 10.3 5.1 0.21 10.3 5.1 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2344 PF10105.9 ETO18174.1 - 1.8 8.4 7.5 3 7.7 7.5 1.3 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2344) Uso1_p115_C PF04871.13 ETO18174.1 - 4.1 7.8 16.7 5.8 7.3 16.7 1.1 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region PUF PF00806.19 ETO18177.1 - 5.3e-06 25.8 0.2 0.061 13.0 0.1 2.7 2 0 0 2 2 2 2 Pumilio-family RNA binding repeat AAA PF00004.29 ETO18178.1 - 0.02 15.3 0.2 0.04 14.3 0.2 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ETO18178.1 - 0.029 14.4 0.0 0.035 14.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF3828 PF12883.7 ETO18179.1 - 0.083 13.3 0.1 0.26 11.7 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3828) RNB PF00773.19 ETO18181.1 - 4e-19 69.1 0.0 2.1e-18 66.7 0.0 2.0 2 0 0 2 2 2 1 RNB domain Dis3l2_C_term PF17877.1 ETO18181.1 - 0.00018 21.8 0.0 0.00044 20.5 0.0 1.6 1 0 0 1 1 1 1 DIS3-like exonuclease 2 C terminal Rrp44_S1 PF17215.3 ETO18181.1 - 0.0017 18.3 0.0 0.0031 17.4 0.0 1.4 1 0 0 1 1 1 1 S1 domain Heliorhodopsin PF18761.1 ETO18182.1 - 0.86 8.9 5.6 1.3 8.3 5.6 1.2 1 0 0 1 1 1 0 Heliorhodopsin CAF1C_H4-bd PF12265.8 ETO18183.1 - 2e-26 92.0 0.5 5.6e-26 90.6 0.5 1.8 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ETO18183.1 - 2.7e-22 78.6 11.6 0.00012 22.7 0.0 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat 2-oxoacid_dh PF00198.23 ETO18186.1 - 5.6e-47 160.1 0.0 6.8e-47 159.9 0.0 1.0 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) DUF5488 PF17590.2 ETO18186.1 - 0.032 13.9 0.0 0.063 13.0 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5488) LpoB PF13036.6 ETO18189.1 - 0.0056 16.6 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 Peptidoglycan-synthase activator LpoB Pex26 PF07163.12 ETO18190.1 - 0.053 12.8 1.1 0.075 12.3 0.1 1.7 2 0 0 2 2 2 0 Pex26 protein MID_MedPIWI PF18296.1 ETO18190.1 - 0.35 10.6 6.6 0.46 10.2 1.6 2.1 2 0 0 2 2 2 0 MID domain of medPIWI CFIA_Pcf11 PF11526.8 ETO18190.1 - 0.58 10.7 10.2 4.5 7.8 3.2 2.4 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 AIF_C PF14721.6 ETO18190.1 - 0.65 10.4 4.8 3.9 7.9 0.5 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Orf78 PF06024.12 ETO18190.1 - 1.9 8.8 6.9 0.65 10.3 1.3 2.2 2 0 0 2 2 2 0 Orf78 (ac78) GHMP_kinases_N PF00288.26 ETO18192.1 - 0.00071 19.8 0.0 0.0036 17.5 0.0 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain GalKase_gal_bdg PF10509.9 ETO18192.1 - 0.0023 17.4 0.0 0.0049 16.4 0.0 1.6 1 0 0 1 1 1 1 Galactokinase galactose-binding signature YojJ PF10372.9 ETO18192.1 - 0.034 14.2 0.1 13 5.9 0.0 2.7 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus ATAD4 PF15321.6 ETO18192.1 - 0.047 15.0 3.3 0.14 13.5 3.3 1.8 1 0 0 1 1 1 0 ATPase family AAA domain containing 4 BppU_IgG PF18667.1 ETO18196.1 - 0.3 11.3 0.9 2.1 8.6 0.0 2.6 4 0 0 4 4 4 0 Baseplate upper protein immunoglobulin like domain LMBR1 PF04791.16 ETO18197.1 - 0.096 11.6 0.4 0.098 11.5 0.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein Pkinase PF00069.25 ETO18198.1 - 2.2e-17 63.3 6.4 1.9e-16 60.3 6.4 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18198.1 - 1.2e-08 34.6 3.9 6.6e-08 32.1 3.9 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO18198.1 - 2.8e-05 24.1 0.0 0.00072 19.6 0.0 2.1 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO18198.1 - 0.0049 16.2 0.0 0.01 15.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family LeuA_dimer PF08502.10 ETO18198.1 - 0.12 12.2 0.0 0.21 11.5 0.0 1.3 1 0 0 1 1 1 0 LeuA allosteric (dimerisation) domain Trypan_PARP PF05887.11 ETO18199.1 - 0.1 12.6 1.5 0.16 11.9 1.5 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CPG4 PF15481.6 ETO18200.1 - 3.6 8.3 8.5 8 7.2 6.1 2.4 2 0 0 2 2 2 0 Chondroitin proteoglycan 4 Ribosomal_60s PF00428.19 ETO18201.1 - 0.19 12.3 2.5 0.4 11.3 2.5 1.5 1 0 0 1 1 1 0 60s Acidic ribosomal protein zf-RING_11 PF17123.5 ETO18202.1 - 0.13 12.0 5.9 1.9 8.3 0.5 3.1 2 0 0 2 2 2 0 RING-like zinc finger zf-HC5HC2H_2 PF13832.6 ETO18202.1 - 0.66 10.2 10.6 0.17 12.0 4.4 2.6 2 2 0 2 2 2 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO18202.1 - 4.8 7.5 12.9 0.59 10.4 5.5 2.8 2 2 0 2 2 2 0 PHD-like zinc-binding domain G-alpha PF00503.20 ETO18203.1 - 2.2e-24 86.3 4.6 2.6e-24 86.0 4.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit PRK PF00485.18 ETO18203.1 - 5.4e-06 26.3 0.2 9.4e-06 25.5 0.2 1.3 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family Rad17 PF03215.15 ETO18203.1 - 0.00015 21.8 1.2 0.00015 21.7 0.1 1.6 2 0 0 2 2 2 1 Rad17 P-loop domain ABC_tran PF00005.27 ETO18203.1 - 0.0036 17.8 1.3 0.0068 16.9 1.3 1.6 1 1 0 1 1 1 1 ABC transporter AAA_29 PF13555.6 ETO18203.1 - 0.0065 16.2 0.1 0.013 15.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain VirE PF05272.11 ETO18203.1 - 0.019 14.7 1.1 0.019 14.7 1.1 1.7 2 0 0 2 2 2 0 Virulence-associated protein E DUF815 PF05673.13 ETO18203.1 - 0.034 13.3 0.1 0.057 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 ETO18203.1 - 0.04 13.9 0.1 0.13 12.3 0.1 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO18203.1 - 0.051 14.0 0.0 0.078 13.4 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain T2SSE PF00437.20 ETO18203.1 - 0.058 12.4 0.0 0.097 11.7 0.0 1.4 1 0 0 1 1 1 0 Type II/IV secretion system protein FtsK_SpoIIIE PF01580.18 ETO18203.1 - 0.068 12.5 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 ETO18203.1 - 0.072 13.4 0.2 0.2 11.9 0.1 1.9 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ETO18203.1 - 0.088 13.2 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO18203.1 - 0.13 12.9 2.0 0.19 12.3 0.7 2.2 2 1 0 2 2 2 0 AAA domain G-alpha PF00503.20 ETO18204.1 - 7.2e-30 104.3 9.3 1.4e-29 103.4 9.3 1.4 1 1 0 1 1 1 1 G-protein alpha subunit PYST-C1 PF09690.10 ETO18204.1 - 0.058 13.1 0.6 0.11 12.3 0.6 1.4 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) FH2 PF02181.23 ETO18205.1 - 6e-08 32.2 2.7 3e-07 29.9 2.7 1.9 1 1 0 1 1 1 1 Formin Homology 2 Domain RRM_1 PF00076.22 ETO18206.1 - 1.7e-36 123.9 0.1 4.1e-16 58.5 0.0 4.4 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO18206.1 - 5.4e-08 32.6 0.0 4.1e-05 23.4 0.0 2.8 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_7 PF16367.5 ETO18206.1 - 3.8e-05 23.7 0.0 0.076 13.1 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif RRM_9 PF18444.1 ETO18206.1 - 0.011 15.6 0.0 0.032 14.1 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif Transformer PF06495.11 ETO18206.1 - 0.48 10.5 9.6 1.1 9.3 9.6 1.6 1 0 0 1 1 1 0 Fruit fly transformer protein FlxA PF14282.6 ETO18207.1 - 9.7 6.3 14.5 0.23 11.4 0.9 2.8 2 1 0 2 2 2 0 FlxA-like protein Menin PF05053.13 ETO18208.1 - 0.012 14.1 1.0 0.014 13.8 1.0 1.0 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO18208.1 - 0.12 11.1 0.3 0.12 11.1 0.3 1.2 1 0 0 1 1 1 0 Presenilin Med3 PF11593.8 ETO18208.1 - 2.1 7.4 16.1 3.6 6.7 16.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal DUF4834 PF16118.5 ETO18208.1 - 3.7 8.6 6.8 1.7 9.7 3.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RGS PF00615.19 ETO18210.1 - 0.012 15.9 1.1 0.015 15.6 1.0 1.4 1 1 0 1 1 1 0 Regulator of G protein signaling domain DUF5436 PF17504.2 ETO18212.1 - 0.0013 19.1 3.8 0.0025 18.1 3.8 1.7 1 1 0 1 1 1 1 Family of unknown function (DUF5436) Cep3 PF16846.5 ETO18212.1 - 0.0026 16.3 4.4 0.0033 16.0 4.4 1.1 1 0 0 1 1 1 1 Centromere DNA-binding protein complex CBF3 subunit B Phage_Gp23 PF10669.9 ETO18212.1 - 0.015 15.6 9.1 0.032 14.6 5.5 2.0 1 1 1 2 2 2 0 Protein gp23 (Bacteriophage A118) XRN1_D2_D3 PF18334.1 ETO18212.1 - 0.033 14.4 1.6 0.17 12.1 0.0 2.2 2 1 0 2 2 2 0 Exoribonuclease Xrn1 D2/D3 domain TRAF_BIRC3_bd PF16673.5 ETO18212.1 - 0.31 10.9 3.0 0.38 10.6 0.9 1.9 2 0 0 2 2 2 0 TNF receptor-associated factor BIRC3 binding domain DHC_N2 PF08393.13 ETO18214.1 - 2.5e-21 76.2 0.2 2.9e-21 76.0 0.2 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 Usher_TcfC PF17271.2 ETO18214.1 - 0.17 10.6 0.1 0.21 10.3 0.1 1.1 1 0 0 1 1 1 0 TcfC Usher-like barrel domain WD40 PF00400.32 ETO18215.1 - 3.1e-57 189.2 21.9 2.2e-09 37.7 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18215.1 - 1.9e-17 63.3 0.6 0.075 13.3 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO18215.1 - 1.2e-15 57.3 0.1 0.1 11.6 0.0 6.8 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO18215.1 - 1.5e-07 31.1 7.5 1.2 9.2 0.1 6.3 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO18215.1 - 3.2e-07 29.2 0.2 0.14 10.7 0.0 3.1 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO18215.1 - 6.6e-07 28.3 8.0 0.15 10.6 0.2 4.9 1 1 4 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO18215.1 - 3.5e-06 26.6 0.0 0.09 12.1 0.0 3.7 1 1 2 4 4 4 3 WD40-like domain Me-amine-dh_H PF06433.11 ETO18215.1 - 0.018 13.9 0.0 1.6 7.5 0.0 2.9 3 1 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) DUF2850 PF11012.8 ETO18215.1 - 0.018 15.3 0.0 0.16 12.3 0.0 2.7 3 1 0 3 3 3 0 Protein of unknown function (DUF2850) SBD PF17882.1 ETO18215.1 - 0.038 13.8 1.7 7.2 6.5 0.1 3.3 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain PQQ PF01011.21 ETO18215.1 - 0.043 13.7 0.0 29 4.8 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat DUF4999 PF16390.5 ETO18215.1 - 0.23 11.7 0.7 33 4.8 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function NACHT PF05729.12 ETO18216.1 - 1e-16 61.3 0.0 5.2e-16 59.0 0.0 2.1 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO18216.1 - 7.9e-07 28.5 2.8 7.9e-07 28.5 2.8 1.9 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 ETO18216.1 - 0.0031 17.8 0.1 0.021 15.1 0.1 2.3 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO18216.1 - 0.0077 16.6 0.1 0.03 14.7 0.0 2.0 1 1 1 2 2 2 1 AAA ATPase domain DUF87 PF01935.17 ETO18216.1 - 0.024 14.7 0.2 0.18 11.9 0.0 2.4 2 0 0 2 2 2 0 Helicase HerA, central domain AFG1_ATPase PF03969.16 ETO18216.1 - 0.039 12.9 0.0 0.08 11.8 0.0 1.5 1 0 0 1 1 1 0 AFG1-like ATPase Nup35_RRM_2 PF14605.6 ETO18216.1 - 0.16 12.0 0.1 0.45 10.6 0.1 1.8 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif MEF2_binding PF09047.10 ETO18216.1 - 0.16 11.8 0.5 0.45 10.4 0.5 1.7 1 0 0 1 1 1 0 MEF2 binding GAPES4 PF17157.4 ETO18216.1 - 0.18 12.2 1.5 14 6.2 0.2 3.3 3 0 0 3 3 3 0 Gammaproteobacterial periplasmic sensor domain NLRC4_HD2 PF17776.1 ETO18216.1 - 0.26 11.8 0.2 0.26 11.8 0.2 3.9 4 1 0 4 4 4 0 NLRC4 helical domain HD2 ABC_tran PF00005.27 ETO18216.1 - 0.47 11.0 2.8 0.58 10.7 0.2 2.4 2 1 0 2 2 2 0 ABC transporter RNA_helicase PF00910.22 ETO18216.1 - 0.97 9.9 0.0 0.97 9.9 0.0 3.0 4 0 0 4 4 4 0 RNA helicase VPS13_mid_rpt PF16910.5 ETO18217.1 - 1.4e-11 44.3 0.3 5.2e-05 22.8 0.0 2.3 2 0 0 2 2 2 2 Repeating coiled region of VPS13 UPRTase PF14681.6 ETO18218.1 - 1.7e-06 27.6 0.0 2.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase CDC45 PF02724.14 ETO18218.1 - 0.058 11.7 18.4 0.072 11.4 18.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Suf PF05843.14 ETO18218.1 - 0.38 10.7 11.8 0.45 10.5 11.8 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) O-antigen_lig PF13425.6 ETO18218.1 - 0.87 8.3 6.7 0.89 8.3 6.7 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CDC27 PF09507.10 ETO18218.1 - 1.2 8.4 32.4 1.7 7.9 32.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Hid1 PF12722.7 ETO18218.1 - 1.9 6.5 14.0 1.9 6.5 14.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MCM_bind PF09739.9 ETO18218.1 - 3 6.2 15.2 3.4 6.0 15.2 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor SID-1_RNA_chan PF13965.6 ETO18218.1 - 4.7 5.5 7.4 5.2 5.3 7.1 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Cellulose_synt PF03552.14 ETO18218.1 - 7.6 4.9 6.1 8.6 4.7 6.1 1.2 1 0 0 1 1 1 0 Cellulose synthase FAM70 PF14967.6 ETO18220.1 - 0.94 8.9 6.6 1.3 8.4 2.4 2.2 2 0 0 2 2 2 0 FAM70 protein Menin PF05053.13 ETO18220.1 - 4.2 5.6 7.9 7 4.9 7.9 1.3 1 0 0 1 1 1 0 Menin DUF4455 PF14643.6 ETO18221.1 - 0.011 14.4 1.7 0.014 14.1 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4455) Glyco_tran_WbsX PF14307.6 ETO18221.1 - 0.018 14.5 0.7 0.031 13.7 0.7 1.5 1 1 0 1 1 1 0 Glycosyltransferase WbsX THRAP3_BCLAF1 PF15440.6 ETO18221.1 - 0.024 13.7 0.1 0.024 13.7 0.1 1.8 2 0 0 2 2 2 0 THRAP3/BCLAF1 family YEATS PF03366.16 ETO18221.1 - 0.088 12.8 0.2 0.22 11.5 0.2 1.7 1 0 0 1 1 1 0 YEATS family putAbiC PF16872.5 ETO18221.1 - 0.092 13.4 1.1 0.32 11.7 0.6 2.1 2 0 0 2 2 2 0 Putative phage abortive infection protein Kei1 PF08552.11 ETO18221.1 - 2.2 8.1 5.8 3.2 7.6 0.6 2.2 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 TRAM_LAG1_CLN8 PF03798.16 ETO18222.1 - 7e-08 32.4 29.4 0.00012 21.9 3.1 2.4 2 0 0 2 2 2 2 TLC domain CHCH PF06747.13 ETO18222.1 - 0.45 10.7 5.2 1.6 8.9 5.2 2.1 1 0 0 1 1 1 0 CHCH domain AOX PF01786.17 ETO18223.1 - 4.1e-76 255.3 0.6 5.1e-76 255.0 0.6 1.1 1 0 0 1 1 1 1 Alternative oxidase MOR2-PAG1_C PF14225.6 ETO18225.1 - 0.041 13.7 0.7 1.3 8.8 0.7 2.1 1 1 0 1 1 1 0 Cell morphogenesis C-terminal CPG4 PF15481.6 ETO18225.1 - 0.058 14.0 0.3 0.12 13.0 0.3 1.5 1 0 0 1 1 1 0 Chondroitin proteoglycan 4 TFIIS_C PF01096.18 ETO18226.1 - 1.7e-08 34.2 4.7 7.3e-07 28.9 0.0 3.0 3 0 0 3 3 3 2 Transcription factor S-II (TFIIS) RNA_POL_M_15KD PF02150.16 ETO18226.1 - 3.1e-07 30.2 7.1 3.1e-07 30.2 7.1 2.4 2 0 0 2 2 2 1 RNA polymerases M/15 Kd subunit Yippee-Mis18 PF03226.14 ETO18226.1 - 0.019 15.2 0.5 0.019 15.2 0.5 1.8 2 0 0 2 2 2 0 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Ribosomal_S27e PF01667.17 ETO18226.1 - 0.02 14.6 0.4 0.02 14.6 0.4 2.7 2 1 0 2 2 2 0 Ribosomal protein S27 C1_1 PF00130.22 ETO18226.1 - 0.03 14.2 1.3 0.03 14.2 1.3 2.0 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) Zn_Tnp_IS1595 PF12760.7 ETO18226.1 - 0.065 13.2 2.8 2.7 8.1 0.0 2.6 2 0 0 2 2 2 0 Transposase zinc-ribbon domain zf-LITAF-like PF10601.9 ETO18226.1 - 0.22 11.8 6.3 13 6.2 0.0 3.7 2 1 1 3 3 3 0 LITAF-like zinc ribbon domain Zn_Tnp_IS1 PF03811.13 ETO18226.1 - 0.26 11.0 1.7 0.74 9.6 0.0 2.2 2 0 0 2 2 2 0 InsA N-terminal domain zinc_ribbon_4 PF13717.6 ETO18226.1 - 0.39 10.7 8.8 1.9 8.5 0.2 2.9 2 1 0 2 2 2 0 zinc-ribbon domain PADR1 PF08063.12 ETO18226.1 - 0.67 9.8 8.9 6 6.7 1.2 3.1 3 0 0 3 3 3 0 PADR1 (NUC008) domain HypA PF01155.19 ETO18226.1 - 1.7 8.7 7.1 2.6 8.1 4.3 2.1 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C4_Topoisom PF01396.19 ETO18226.1 - 2.7 7.9 9.4 12 5.7 0.4 3.3 3 0 0 3 3 3 0 Topoisomerase DNA binding C4 zinc finger zf-B_box PF00643.24 ETO18226.1 - 4.6 7.5 9.4 30 4.9 0.1 2.8 2 1 0 2 2 2 0 B-box zinc finger zf_UBZ PF18439.1 ETO18226.1 - 8.5 6.1 8.7 26 4.5 0.4 3.2 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger TPPK_C PF12555.8 ETO18227.1 - 0.00053 20.0 1.0 0.00053 20.0 1.0 2.6 1 1 1 2 2 2 1 Thiamine pyrophosphokinase C terminal Wzy_C PF04932.15 ETO18227.1 - 0.2 11.3 10.8 0.21 11.2 10.8 1.2 1 0 0 1 1 1 0 O-Antigen ligase 7tm_7 PF08395.12 ETO18227.1 - 0.67 9.1 10.5 0.75 8.9 10.5 1.0 1 0 0 1 1 1 0 7tm Chemosensory receptor DUF4191 PF13829.6 ETO18227.1 - 1.8 7.8 13.4 2.1 7.6 13.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4191) CbiQ PF02361.16 ETO18227.1 - 2.9 7.4 17.9 3.4 7.2 17.9 1.1 1 0 0 1 1 1 0 Cobalt transport protein CobD_Cbib PF03186.13 ETO18227.1 - 3 7.0 7.3 3.4 6.8 7.3 1.2 1 0 0 1 1 1 0 CobD/Cbib protein DUF3043 PF11241.8 ETO18227.1 - 3.4 7.7 10.2 4.3 7.3 10.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) DUF5601 PF18151.1 ETO18228.1 - 0.059 13.7 0.4 0.47 10.8 0.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5601) AI-2E_transport PF01594.16 ETO18228.1 - 0.065 12.4 0.2 0.087 12.0 0.2 1.1 1 0 0 1 1 1 0 AI-2E family transporter Neur_chan_memb PF02932.16 ETO18228.1 - 0.91 9.5 4.0 1.2 9.1 4.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RRN3 PF05327.11 ETO18228.1 - 1.7 7.1 8.3 2.6 6.5 8.2 1.3 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4407 PF14362.6 ETO18228.1 - 2.2 7.6 6.4 2.3 7.5 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 ETO18228.1 - 5 5.3 10.8 5.6 5.1 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 ETO18228.1 - 7.9 6.4 16.7 13 5.7 16.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF3546 PF12066.8 ETO18230.1 - 0.005 17.0 1.7 0.0095 16.1 1.6 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF3546) Stevor PF17410.2 ETO18230.1 - 0.011 15.3 0.4 0.013 15.0 0.4 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Pept_tRNA_hydro PF01195.19 ETO18230.1 - 0.065 13.2 0.0 0.098 12.6 0.0 1.3 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase CrgA PF06781.12 ETO18231.1 - 0.29 11.2 1.4 0.89 9.6 0.0 2.4 3 0 0 3 3 3 0 Cell division protein CrgA EamA PF00892.20 ETO18233.1 - 2.3e-11 44.0 39.3 8.7e-08 32.4 8.3 3.7 3 1 0 3 3 3 2 EamA-like transporter family Nuc_sug_transp PF04142.15 ETO18233.1 - 1.6e-05 24.3 13.4 6.7e-05 22.2 13.4 2.0 1 1 0 1 1 1 1 Nucleotide-sugar transporter DUF3522 PF12036.8 ETO18233.1 - 9.2e-05 22.8 1.5 9.2e-05 22.8 1.5 3.8 1 1 1 3 3 3 1 Protein of unknown function (DUF3522) TMEM154 PF15102.6 ETO18233.1 - 0.036 14.0 0.0 11 6.0 0.0 2.7 2 0 0 2 2 2 0 TMEM154 protein family SLC35F PF06027.12 ETO18233.1 - 0.12 11.9 19.3 0.55 9.7 19.3 2.0 1 1 0 1 1 1 0 Solute carrier family 35 Sec20 PF03908.13 ETO18234.1 - 0.00076 19.3 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Sec20 WD40 PF00400.32 ETO18235.1 - 1.1e-31 108.4 30.5 1.3e-06 29.0 2.3 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO18235.1 - 2.6e-08 33.0 5.7 0.022 13.4 0.1 4.9 1 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO18235.1 - 4.6e-08 33.3 3.4 1.5 9.2 0.0 5.6 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO18236.1 - 4.1e-43 144.5 32.7 5e-07 30.3 1.9 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18236.1 - 3.3e-11 43.3 3.2 0.26 11.6 0.0 6.2 3 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18236.1 - 1.5e-06 27.2 13.2 0.049 12.3 0.5 5.9 2 2 4 6 6 6 6 Nucleoporin Nup120/160 DUF1481 PF07356.12 ETO18236.1 - 0.35 10.6 2.6 7.1 6.4 0.1 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF1481) DUF953 PF06110.11 ETO18237.1 - 7e-37 125.7 0.9 8.4e-37 125.4 0.9 1.1 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF953) Thioredoxin_9 PF14595.6 ETO18237.1 - 0.17 11.6 1.5 0.27 11.0 1.5 1.5 1 1 0 1 1 1 0 Thioredoxin Jak1_Phl PF17887.1 ETO18238.1 - 0.014 15.4 7.8 0.014 15.4 7.8 2.9 2 1 1 3 3 3 0 Jak1 pleckstrin homology-like domain Hamartin PF04388.12 ETO18238.1 - 0.19 10.4 30.2 0.25 10.0 30.2 1.1 1 0 0 1 1 1 0 Hamartin protein Adaptin_binding PF10199.9 ETO18238.1 - 3.7 8.2 32.1 0.093 13.3 5.1 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 LAP1C PF05609.12 ETO18238.1 - 8.1 5.4 32.7 12 4.8 32.7 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Eapp_C PF10238.9 ETO18239.1 - 0.26 11.4 10.9 3.3 7.8 0.1 2.3 2 0 0 2 2 2 0 E2F-associated phosphoprotein MPM1 PF17234.2 ETO18239.1 - 2 8.7 15.2 6.1 7.1 11.2 2.2 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Ctr PF04145.15 ETO18239.1 - 3.8 8.1 8.1 0.35 11.5 2.1 2.1 2 1 0 2 2 2 0 Ctr copper transporter family Kinesin PF00225.23 ETO18240.1 - 1.6e-29 102.9 0.7 1.6e-29 102.9 0.7 1.9 2 0 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO18240.1 - 9.3e-22 77.6 1.0 9.3e-22 77.6 1.0 3.2 3 0 0 3 3 3 1 Microtubule binding DUF5578 PF17741.1 ETO18240.1 - 0.0015 18.0 17.6 0.0089 15.5 13.0 3.8 1 1 2 3 3 3 1 Family of unknown function (DUF5578) AAA_24 PF13479.6 ETO18240.1 - 0.0087 15.8 0.0 0.023 14.4 0.0 1.7 1 0 0 1 1 1 1 AAA domain Asp_protease PF09668.10 ETO18240.1 - 0.046 13.5 0.0 0.48 10.2 0.0 2.3 2 0 0 2 2 2 0 Aspartyl protease Kinesin PF00225.23 ETO18241.1 - 3e-47 161.2 1.0 3e-47 161.2 1.0 1.8 2 1 0 2 2 2 1 Kinesin motor domain bZIP_2 PF07716.15 ETO18241.1 - 0.035 14.2 5.5 0.035 14.2 5.5 3.0 2 1 0 2 2 2 0 Basic region leucine zipper Peptidase_M91 PF14891.6 ETO18241.1 - 0.061 13.6 2.7 0.89 9.8 0.1 2.3 2 0 0 2 2 2 0 Effector protein TPR_12 PF13424.6 ETO18242.1 - 9.3e-20 70.7 0.9 2.8e-08 33.9 0.1 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO18242.1 - 1.8e-09 37.1 1.2 0.0096 15.8 0.0 5.1 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18242.1 - 2.2e-08 33.5 16.9 0.0007 19.3 0.4 6.0 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18242.1 - 3.2e-07 29.9 0.8 0.06 13.4 0.1 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18242.1 - 1.8e-06 27.7 17.3 0.00046 20.2 0.2 6.3 5 2 0 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18242.1 - 1.8e-06 27.6 8.7 0.0017 18.3 0.5 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO18242.1 - 0.026 15.2 1.2 8.2 7.3 0.1 3.1 3 0 0 3 3 3 0 Sel1 repeat TPR_14 PF13428.6 ETO18242.1 - 0.07 14.0 0.0 1.2 10.2 0.0 2.9 3 0 0 3 3 2 0 Tetratricopeptide repeat Globin PF00042.22 ETO18242.1 - 0.09 13.3 0.1 0.63 10.6 0.1 2.4 2 0 0 2 2 2 0 Globin TPR_17 PF13431.6 ETO18242.1 - 0.13 12.7 2.6 24 5.6 0.3 3.8 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18242.1 - 0.13 13.0 0.9 2 9.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18242.1 - 0.52 10.0 5.7 57 3.5 0.0 4.3 3 2 1 4 4 4 0 TPR repeat MIT PF04212.18 ETO18242.1 - 1.7 8.8 8.0 0.47 10.6 0.2 3.5 2 1 2 4 4 4 0 MIT (microtubule interacting and transport) domain Utp13 PF08625.11 ETO18242.1 - 8.5 6.3 6.8 1.2 9.1 1.2 2.5 3 1 0 3 3 3 0 Utp13 specific WD40 associated domain CDC45 PF02724.14 ETO18243.1 - 0.0089 14.4 22.9 0.011 14.1 22.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO18243.1 - 0.028 12.7 28.6 0.033 12.4 28.6 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ETO18243.1 - 0.17 9.9 27.3 0.23 9.5 27.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi SAPS PF04499.15 ETO18243.1 - 2.3 6.9 15.6 2.5 6.8 15.6 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Fez1 PF06818.15 ETO18244.1 - 0.0042 17.6 13.9 0.0078 16.7 13.9 1.4 1 0 0 1 1 1 1 Fez1 ARGLU PF15346.6 ETO18244.1 - 0.55 10.1 17.7 0.9 9.4 17.7 1.3 1 0 0 1 1 1 0 Arginine and glutamate-rich 1 Exonuc_VII_L PF02601.15 ETO18244.1 - 1.7 8.2 7.6 2.2 7.7 7.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF5383 PF17355.2 ETO18245.1 - 0.0042 17.5 0.1 0.0042 17.5 0.1 2.2 2 1 0 2 2 2 1 Family of unknown function (DUF5383) MTABC_N PF16185.5 ETO18245.1 - 0.079 12.5 0.4 0.079 12.5 0.4 2.8 2 1 0 2 2 2 0 Mitochondrial ABC-transporter N-terminal five TM region DUF423 PF04241.15 ETO18245.1 - 0.13 12.5 0.0 0.32 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF423) PGA2 PF07543.12 ETO18246.1 - 0.21 11.6 7.1 1.8 8.5 0.6 2.2 1 1 1 2 2 2 0 Protein trafficking PGA2 UPF0370 PF13980.6 ETO18247.1 - 0.25 11.4 1.4 0.52 10.4 1.4 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0370) YMF19 PF02326.15 ETO18247.1 - 0.59 11.0 5.1 0.18 12.6 1.0 2.1 2 0 0 2 2 2 0 Plant ATP synthase F0 Alpha_kinase PF02816.18 ETO18248.1 - 8.8e-39 133.5 0.0 8.8e-39 133.5 0.0 2.4 2 1 0 3 3 3 1 Alpha-kinase family CobT PF06213.12 ETO18248.1 - 0.03 13.7 11.6 0.06 12.7 11.6 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nucleo_P87 PF07267.11 ETO18248.1 - 0.16 10.8 10.9 0.19 10.6 10.9 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TRAP_alpha PF03896.16 ETO18248.1 - 2 7.5 9.0 3.6 6.7 9.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 ETO18248.1 - 2.6 6.7 16.7 3.4 6.3 16.7 1.2 1 0 0 1 1 1 0 Presenilin CDC27 PF09507.10 ETO18248.1 - 3.2 7.0 31.0 4.2 6.7 31.0 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SID-1_RNA_chan PF13965.6 ETO18248.1 - 3.4 6.0 5.8 4.3 5.6 5.8 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 ETO18248.1 - 3.6 6.4 5.0 4.9 6.0 5.0 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator DNA_pol_phi PF04931.13 ETO18248.1 - 3.6 5.6 20.3 5.1 5.1 20.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ETO18248.1 - 6.9 6.3 18.4 0.13 12.0 11.0 1.8 2 1 0 2 2 2 0 FAM176 family Serinc PF03348.15 ETO18249.1 - 6.9e-29 101.0 3.3 9.7e-29 100.5 3.3 1.2 1 0 0 1 1 1 1 Serine incorporator (Serinc) Tmemb_14 PF03647.13 ETO18249.1 - 0.0069 17.1 2.4 0.11 13.2 0.0 2.9 2 1 0 2 2 2 1 Transmembrane proteins 14C DUF3169 PF11368.8 ETO18249.1 - 0.014 14.9 2.3 0.014 14.9 2.3 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) DUF1980 PF09323.10 ETO18249.1 - 0.025 14.5 0.3 0.025 14.5 0.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) Spo7 PF03907.13 ETO18249.1 - 0.038 13.5 0.2 0.038 13.5 0.2 1.8 2 1 0 2 2 2 0 Spo7-like protein Zip PF02535.22 ETO18249.1 - 0.11 11.7 4.0 0.26 10.5 4.0 1.7 1 1 0 1 1 1 0 ZIP Zinc transporter DHHC PF01529.20 ETO18249.1 - 0.17 12.0 13.2 1.1 9.4 5.0 2.5 1 1 0 2 2 2 0 DHHC palmitoyltransferase DUF4692 PF15763.5 ETO18249.1 - 0.17 12.4 2.4 0.19 12.2 0.0 2.0 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) DUF4834 PF16118.5 ETO18249.1 - 0.6 11.1 3.8 0.44 11.5 0.4 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF1218 PF06749.12 ETO18249.1 - 1.2 9.7 9.4 3.1 8.4 1.3 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1218) TUTF7_u4 PF16631.5 ETO18249.1 - 3.5 8.3 12.7 0.29 11.8 7.7 1.8 2 1 0 2 2 1 0 Unstructured region 4 on terminal uridylyltransferase 7 DUF4131 PF13567.6 ETO18249.1 - 6.1 6.5 11.6 2.6 7.7 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) OppC_N PF12911.7 ETO18249.1 - 6.8 6.8 7.9 16 5.6 0.1 2.9 2 1 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C APG17 PF04108.12 ETO18253.1 - 6.4e-09 35.4 3.6 6.4e-09 35.4 3.6 4.0 2 2 0 3 3 3 1 Autophagy protein Apg17 SCO1-SenC PF02630.14 ETO18253.1 - 0.056 13.4 0.7 2.5 8.0 0.1 2.7 2 0 0 2 2 2 0 SCO1/SenC ESCRT-II PF05871.12 ETO18253.1 - 0.37 11.0 4.8 0.11 12.8 1.1 2.0 2 0 0 2 2 2 0 ESCRT-II complex subunit Secretin_N_2 PF07655.13 ETO18253.1 - 0.7 10.5 9.6 2.6 8.6 9.6 2.0 1 0 0 1 1 1 0 Secretin N-terminal domain PRT_C PF08372.10 ETO18254.1 - 0.00031 20.5 0.0 0.00045 20.0 0.0 1.4 1 0 0 1 1 1 1 Plant phosphoribosyltransferase C-terminal DUF639 PF04842.12 ETO18254.1 - 0.019 14.4 0.1 0.032 13.6 0.1 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF639) HSDR_N PF04313.14 ETO18254.1 - 0.026 14.5 1.6 0.036 14.0 1.6 1.2 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) Lipoprotein_9 PF03180.14 ETO18256.1 - 0.065 12.3 0.1 0.091 11.9 0.1 1.1 1 0 0 1 1 1 0 NLPA lipoprotein Ribosomal_60s PF00428.19 ETO18258.1 - 0.36 11.5 8.6 4.4 8.0 0.1 2.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein SOG2 PF10428.9 ETO18258.1 - 0.53 9.4 4.3 0.76 8.9 4.3 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DNA_pol_phi PF04931.13 ETO18258.1 - 7.1 4.6 10.7 10 4.1 10.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi PI3K_1B_p101 PF10486.9 ETO18259.1 - 0.08 10.7 2.5 0.096 10.5 2.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit BAF1_ABF1 PF04684.13 ETO18259.1 - 0.78 8.7 23.6 1 8.4 23.6 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Hamartin PF04388.12 ETO18259.1 - 2.1 6.9 9.7 2.7 6.6 9.7 1.2 1 0 0 1 1 1 0 Hamartin protein DUF4551 PF15087.6 ETO18259.1 - 5.7 5.6 8.3 6.3 5.5 8.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CSG2 PF16965.5 ETO18259.1 - 6.2 5.7 5.5 8.2 5.2 5.5 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Utp14 PF04615.13 ETO18259.1 - 7.5 5.0 16.3 8.5 4.8 16.3 1.1 1 0 0 1 1 1 0 Utp14 protein FH2 PF02181.23 ETO18261.1 - 2.1e-69 234.5 14.6 2.1e-69 234.5 14.6 3.0 3 0 0 3 3 3 1 Formin Homology 2 Domain PH PF00169.29 ETO18261.1 - 2.4e-06 28.0 3.8 2.7e-05 24.6 0.1 3.8 3 0 0 3 3 3 1 PH domain Mpp10 PF04006.12 ETO18262.1 - 9.3e-40 136.7 52.5 8.5e-30 103.8 23.8 2.8 2 1 0 2 2 2 2 Mpp10 protein NSP2-B_epitope PF14757.6 ETO18262.1 - 0.081 12.6 0.1 0.39 10.4 0.0 1.9 2 0 0 2 2 2 0 Immunogenic region of nsp2 protein of arterivirus polyprotein FAM60A PF15396.6 ETO18262.1 - 3.1 7.7 27.5 0.59 10.1 0.2 3.2 2 1 0 3 3 3 0 Protein Family FAM60A HATPase_c PF02518.26 ETO18263.1 - 5.2e-20 72.0 0.3 1.3e-19 70.8 0.1 1.8 2 0 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO18263.1 - 0.00024 20.9 1.3 0.00064 19.6 0.3 2.1 2 1 0 2 2 2 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase DUF3160 PF11369.8 ETO18263.1 - 0.068 11.6 0.6 0.094 11.2 0.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3160) Spore_III_AB PF09548.10 ETO18263.1 - 0.1 12.7 0.1 0.19 11.8 0.1 1.5 1 0 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) ParB PF08775.10 ETO18263.1 - 0.22 12.0 3.2 0.11 13.0 0.7 1.8 2 0 0 2 2 2 0 ParB family SSF PF00474.17 ETO18264.1 - 4.6e-18 65.3 31.7 8.5e-18 64.4 31.6 1.5 1 1 0 1 1 1 1 Sodium:solute symporter family DDE_Tnp_IS1595 PF12762.7 ETO18265.1 - 7.6e-39 133.2 0.3 1.1e-38 132.7 0.3 1.2 1 0 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.7 ETO18265.1 - 1.9e-11 43.8 4.5 3.7e-11 42.8 4.5 1.5 1 0 0 1 1 1 1 Transposase zinc-ribbon domain Sigma70_r4_2 PF08281.12 ETO18265.1 - 0.12 12.1 0.0 0.79 9.4 0.0 2.0 2 0 0 2 2 2 0 Sigma-70, region 4 PA28_beta PF02252.18 ETO18266.1 - 5e-48 162.5 2.3 5e-48 162.5 2.3 1.9 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETO18266.1 - 0.0016 18.5 0.3 0.004 17.2 0.3 1.7 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit Gon7 PF08738.10 ETO18266.1 - 0.0079 16.3 0.5 0.016 15.3 0.5 1.5 1 0 0 1 1 1 1 Gon7 family DUF4407 PF14362.6 ETO18266.1 - 0.14 11.5 2.7 0.2 10.9 2.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Aldo_ket_red PF00248.21 ETO18267.1 - 1.4e-07 31.0 0.1 1.8e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 Aldo/keto reductase family Aldo_ket_red PF00248.21 ETO18268.1 - 6.7e-19 68.2 0.0 8.4e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family YabA PF06156.13 ETO18268.1 - 4.9 7.9 5.9 1.1 9.9 0.2 2.3 2 1 0 2 2 2 0 Initiation control protein YabA Sulfotransfer_2 PF03567.14 ETO18270.1 - 1.1e-07 32.0 1.4 4.5e-06 26.8 1.4 2.7 1 1 0 1 1 1 1 Sulfotransferase family EcsB PF05975.12 ETO18270.1 - 0.033 13.0 0.3 0.033 13.0 0.3 1.7 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB WD40 PF00400.32 ETO18272.1 - 2.6e-32 110.3 22.2 2.2e-06 28.3 0.1 7.4 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18272.1 - 2e-12 47.3 2.5 0.0043 17.3 0.0 5.2 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18272.1 - 1.3e-08 34.0 6.4 0.12 11.0 0.0 5.4 2 1 3 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO18272.1 - 0.00075 19.4 3.5 0.52 10.2 0.2 3.7 1 1 1 4 4 4 2 Eukaryotic translation initiation factor eIF2A PEP_mutase PF13714.6 ETO18273.1 - 2e-38 132.2 0.1 2.3e-38 132.0 0.1 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase ICL PF00463.21 ETO18273.1 - 1.3e-14 53.7 0.1 1.6e-14 53.3 0.1 1.1 1 0 0 1 1 1 1 Isocitrate lyase family Glycolytic PF00274.19 ETO18273.1 - 0.043 12.6 0.0 0.07 11.8 0.0 1.3 1 0 0 1 1 1 0 Fructose-bisphosphate aldolase class-I DUF2207 PF09972.9 ETO18274.1 - 0.63 8.7 8.2 0.21 10.3 5.4 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 ETO18275.1 - 5e-35 118.9 10.6 2e-08 34.7 0.1 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18275.1 - 1.9e-14 53.7 0.1 0.0017 18.6 0.0 4.5 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO18275.1 - 5.1e-06 26.0 0.2 0.00037 19.9 0.0 2.2 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO18275.1 - 0.00077 18.2 4.2 0.025 13.3 1.0 3.5 1 1 0 2 2 2 1 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO18275.1 - 0.00094 18.2 0.0 0.78 8.6 0.0 3.1 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein BBS2_Mid PF14783.6 ETO18275.1 - 0.0032 17.5 0.0 4.6 7.3 0.0 3.6 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 ETO18275.1 - 0.03 13.6 0.5 0.51 9.6 0.1 2.6 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Utp8 PF10395.9 ETO18275.1 - 0.035 12.6 0.0 0.044 12.3 0.0 1.1 1 0 0 1 1 1 0 Utp8 family PQQ_2 PF13360.6 ETO18275.1 - 0.055 13.0 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 PQQ-like domain Me-amine-dh_H PF06433.11 ETO18275.1 - 0.074 11.9 0.0 0.3 9.9 0.0 1.8 1 1 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO18275.1 - 0.11 11.0 0.0 0.4 9.2 0.0 1.7 1 1 1 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO18275.1 - 0.11 12.4 0.7 90 3.2 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat HEAT_2 PF13646.6 ETO18277.1 - 6.9e-11 42.4 0.0 0.0014 19.0 0.0 4.1 4 0 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ETO18277.1 - 5.3e-07 29.3 0.0 0.67 10.4 0.0 7.5 8 0 0 8 8 8 1 HEAT repeat HEAT_EZ PF13513.6 ETO18277.1 - 2.6e-05 24.6 0.0 1.8 9.2 0.0 5.3 6 1 1 7 7 7 2 HEAT-like repeat Cnd1 PF12717.7 ETO18277.1 - 0.014 15.5 1.3 0.014 15.5 1.3 5.9 3 1 1 5 5 5 0 non-SMC mitotic condensation complex subunit 1 UME PF08064.13 ETO18277.1 - 0.041 13.8 0.1 4.2 7.3 0.0 3.4 2 1 0 2 2 2 0 UME (NUC010) domain DUF3907 PF13047.6 ETO18277.1 - 0.07 13.1 2.3 1.2 9.1 0.0 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF3907) DnaG_DnaB_bind PF08278.11 ETO18277.1 - 0.071 13.7 0.5 6.6 7.3 0.2 3.9 2 2 3 5 5 5 0 DNA primase DnaG DnaB-binding DUF3349 PF11829.8 ETO18277.1 - 0.091 13.5 0.1 47 4.8 0.0 4.6 5 1 0 5 5 5 0 Protein of unknown function (DUF3349) DNA_pol_B_palm PF14792.6 ETO18278.1 - 3.1e-30 104.7 0.0 3e-29 101.5 0.0 2.1 2 0 0 2 2 2 1 DNA polymerase beta palm DNA_pol_B_thumb PF14791.6 ETO18278.1 - 3.1e-22 78.5 0.0 1.9e-21 76.0 0.0 2.2 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_lambd_f PF10391.9 ETO18278.1 - 9.1e-16 57.4 0.8 2.7e-15 55.9 0.8 1.9 1 1 0 1 1 1 1 Fingers domain of DNA polymerase lambda HHH_8 PF14716.6 ETO18278.1 - 8.3e-11 42.1 0.5 6.4e-10 39.3 0.0 2.7 3 0 0 3 3 3 1 Helix-hairpin-helix domain NTP_transf_2 PF01909.23 ETO18278.1 - 0.00038 20.7 0.0 0.001 19.3 0.0 1.7 1 0 0 1 1 1 1 Nucleotidyltransferase domain Sigma_reg_C PF13791.6 ETO18278.1 - 0.089 13.0 0.1 3.5 7.8 0.1 2.6 3 0 0 3 3 3 0 Sigma factor regulator C-terminal HHH_3 PF12836.7 ETO18278.1 - 0.096 13.0 0.9 0.27 11.5 0.3 2.1 2 0 0 2 2 2 0 Helix-hairpin-helix motif HHH_5 PF14520.6 ETO18278.1 - 0.13 12.9 0.0 15 6.2 0.1 2.6 2 0 0 2 2 2 0 Helix-hairpin-helix domain Cpn60_TCP1 PF00118.24 ETO18279.1 - 2.4e-71 240.9 1.5 1.5e-37 129.4 0.3 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family DUF1071 PF06378.11 ETO18279.1 - 0.025 14.1 0.0 0.041 13.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1071) TnpV PF14198.6 ETO18279.1 - 0.18 11.8 0.1 0.57 10.2 0.1 1.8 1 1 1 2 2 2 0 Transposon-encoded protein TnpV Cpn60_TCP1 PF00118.24 ETO18280.1 - 6.8e-15 54.7 0.0 7.7e-15 54.5 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ax_dynein_light PF10211.9 ETO18281.1 - 0.0015 18.5 7.3 0.0015 18.5 7.3 3.6 2 1 1 3 3 2 1 Axonemal dynein light chain ADIP PF11559.8 ETO18281.1 - 0.011 15.9 9.6 0.011 15.9 9.6 3.8 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.7 ETO18281.1 - 0.013 15.7 10.8 0.013 15.7 10.8 4.2 1 1 2 4 4 4 0 Tropomyosin like HALZ PF02183.18 ETO18281.1 - 0.026 14.7 0.9 0.026 14.7 0.9 5.2 4 1 2 6 6 6 0 Homeobox associated leucine zipper Leu_zip PF15294.6 ETO18281.1 - 0.055 13.0 40.4 0.71 9.3 15.6 2.8 1 1 1 2 2 2 0 Leucine zipper Nipped-B_C PF12830.7 ETO18281.1 - 0.11 12.4 4.2 0.23 11.4 4.2 1.8 1 1 0 1 1 1 0 Sister chromatid cohesion C-terminus Tissue_fac PF01108.17 ETO18281.1 - 0.19 11.6 2.3 0.5 10.2 2.3 1.7 1 1 0 1 1 1 0 Tissue factor HOOK PF05622.12 ETO18281.1 - 0.48 8.5 44.3 0.6 8.2 44.3 1.0 1 0 0 1 1 1 0 HOOK protein RnlB_antitoxin PF15933.5 ETO18281.1 - 0.97 9.8 9.9 0.11 12.8 3.3 2.7 2 1 0 2 2 2 0 Antitoxin to bacterial toxin RNase LS or RnlA Lectin_N PF03954.14 ETO18281.1 - 1.3 8.8 15.1 0.042 13.6 2.2 3.0 2 2 0 2 2 2 0 Hepatic lectin, N-terminal domain Fungal_TACC PF12709.7 ETO18281.1 - 5.3 7.6 40.0 0.068 13.6 3.5 5.3 2 2 3 5 5 5 0 Fungal Transforming acidic coiled-coil (TACC) proteins DASH_Dad3 PF08656.10 ETO18281.1 - 6.7 6.9 15.4 0.33 11.1 4.7 3.5 3 1 0 3 3 3 0 DASH complex subunit Dad3 Saccharop_dh_N PF04455.12 ETO18281.1 - 6.7 7.2 7.5 16 6.0 0.6 3.4 1 1 2 4 4 4 0 LOR/SDH bifunctional enzyme conserved region APG6_N PF17675.1 ETO18281.1 - 7.4 7.1 47.7 0.3 11.6 2.4 3.8 1 1 3 4 4 4 0 Apg6 coiled-coil region RCC1 PF00415.18 ETO18282.1 - 1.8e-26 92.5 11.0 3.7e-07 30.7 0.8 5.5 6 0 0 6 6 6 5 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO18282.1 - 4.1e-21 74.2 15.2 1.4e-09 37.5 0.4 3.4 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat WD40 PF00400.32 ETO18284.1 - 6.9e-20 71.0 12.3 2e-06 28.4 0.3 4.4 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO18284.1 - 1e-05 24.4 1.0 0.15 10.7 0.1 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO18284.1 - 0.00083 19.6 2.2 3 8.2 0.2 3.4 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain MFS_1 PF07690.16 ETO18285.1 - 0.00013 21.1 0.0 0.00015 20.8 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ETO18285.1 - 0.0095 14.8 0.4 0.018 13.9 0.4 1.4 1 0 0 1 1 1 1 MFS_1 like family Sigma70_ner PF04546.13 ETO18285.1 - 0.055 13.3 1.6 0.075 12.9 1.6 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region Ctr PF04145.15 ETO18285.1 - 0.097 13.3 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 Ctr copper transporter family DUF1673 PF07895.11 ETO18285.1 - 0.92 9.2 3.1 5 6.8 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1673) PGK PF00162.19 ETO18286.1 - 9.5e-107 357.2 0.2 1.8e-106 356.3 0.2 1.4 1 0 0 1 1 1 1 Phosphoglycerate kinase Gp_dh_C PF02800.20 ETO18286.1 - 1.5e-57 193.6 0.3 3e-57 192.6 0.3 1.5 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain Gp_dh_N PF00044.24 ETO18286.1 - 4.7e-32 110.3 0.5 4.7e-32 110.3 0.5 2.9 4 0 0 4 4 4 1 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain HTH_25 PF13413.6 ETO18286.1 - 8.8e-16 57.5 0.0 2.4e-15 56.1 0.0 1.8 1 0 0 1 1 1 1 Helix-turn-helix domain Polyketide_cyc PF03364.20 ETO18286.1 - 2e-06 28.1 0.0 4.1e-06 27.0 0.0 1.6 1 0 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport HTH_19 PF12844.7 ETO18286.1 - 2e-05 24.5 0.1 8.4e-05 22.5 0.1 2.2 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_3 PF01381.22 ETO18286.1 - 4e-05 23.6 0.2 0.00013 22.0 0.2 2.0 1 0 0 1 1 1 1 Helix-turn-helix HTH_31 PF13560.6 ETO18286.1 - 0.0018 18.6 0.0 0.0044 17.3 0.0 1.7 1 0 0 1 1 1 1 Helix-turn-helix domain DUF2199 PF09965.9 ETO18286.1 - 0.061 13.4 0.1 0.16 12.1 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2199) F420_oxidored PF03807.17 ETO18286.1 - 0.064 13.8 2.6 0.2 12.3 0.2 2.9 3 0 0 3 3 3 0 NADP oxidoreductase coenzyme F420-dependent SHD1 PF03983.12 ETO18286.1 - 0.1 12.5 0.0 0.69 9.8 0.0 2.5 2 0 0 2 2 2 0 SLA1 homology domain 1, SHD1 Rxt3 PF08642.10 ETO18288.1 - 0.48 11.2 7.8 0.42 11.4 3.5 2.3 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 FAM176 PF14851.6 ETO18288.1 - 1.7 8.3 7.4 1.3 8.7 0.2 2.4 2 0 0 2 2 2 0 FAM176 family CSG2 PF16965.5 ETO18288.1 - 2.4 7.0 8.4 0.44 9.4 1.8 2.1 1 1 1 2 2 2 0 Ceramide synthase regulator DUF4803 PF16061.5 ETO18289.1 - 0.46 9.9 3.3 3 7.2 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4803) WD40 PF00400.32 ETO18290.1 - 1.7e-07 31.8 8.6 0.016 16.1 0.3 4.7 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18290.1 - 0.0039 17.4 0.0 1.8 8.9 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.6 ETO18291.1 - 5.4e-07 29.5 0.1 0.002 18.1 0.0 2.9 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO18291.1 - 7.9e-07 28.8 0.7 0.02 14.9 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO18291.1 - 1.1e-06 28.7 0.6 0.31 11.4 0.0 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO18291.1 - 6e-06 25.8 0.7 0.072 12.7 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO18291.1 - 0.00018 21.4 0.8 13 5.9 0.0 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO18291.1 - 0.0031 17.8 0.0 0.94 9.8 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Neur_chan_memb PF02932.16 ETO18292.1 - 0.061 13.4 0.5 0.096 12.7 0.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO18292.1 - 0.084 11.6 9.4 0.14 10.9 9.4 1.3 1 0 0 1 1 1 0 Presenilin Hydin_ADK PF17213.3 ETO18292.1 - 0.77 10.0 5.3 1.5 9.1 5.3 1.4 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Macoilin PF09726.9 ETO18292.1 - 0.85 8.1 12.5 1.1 7.7 12.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF4551 PF15087.6 ETO18292.1 - 1.5 7.6 6.3 2 7.2 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Menin PF05053.13 ETO18292.1 - 2.4 6.4 11.9 3.1 6.1 11.9 1.1 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 ETO18292.1 - 4.3 6.2 11.6 6.7 5.6 11.6 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 ETO18292.1 - 4.5 7.2 10.3 7.1 6.6 10.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Med18 PF09637.10 ETO18294.1 - 2e-06 27.9 2.0 0.00016 21.6 2.0 2.2 1 1 0 1 1 1 1 Med18 protein Vps51 PF08700.11 ETO18294.1 - 0.015 15.4 0.3 0.2 11.7 0.0 2.4 1 1 1 2 2 2 0 Vps51/Vps67 SapB_1 PF05184.15 ETO18294.1 - 0.19 11.8 1.2 0.34 11.0 0.1 2.0 3 0 0 3 3 3 0 Saposin-like type B, region 1 NDUFA12 PF05071.16 ETO18295.1 - 1.2e-29 103.0 0.3 2.4e-29 102.0 0.3 1.5 1 1 0 1 1 1 1 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF719 PF05334.13 ETO18297.1 - 0.032 14.4 0.2 0.032 14.4 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF719) FANCI_HD2 PF14680.6 ETO18297.1 - 0.088 12.0 2.2 0.094 11.9 0.1 1.9 2 0 0 2 2 2 0 FANCI helical domain 2 RSN1_TM PF13967.6 ETO18299.1 - 0.0055 16.5 0.1 0.0055 16.5 0.1 2.1 3 0 0 3 3 3 1 Late exocytosis, associated with Golgi transport PHM7_cyt PF14703.6 ETO18299.1 - 0.018 15.3 0.0 0.22 11.7 0.0 2.2 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter PH_4 PF15404.6 ETO18299.1 - 0.094 12.5 1.0 0.14 12.0 1.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Secretin_N_2 PF07655.13 ETO18299.1 - 0.16 12.5 13.1 0.25 11.9 13.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Sulfate_transp PF00916.20 ETO18300.1 - 3e-30 105.3 2.7 3.9e-30 104.9 2.7 1.0 1 0 0 1 1 1 1 Sulfate permease family STAS PF01740.21 ETO18301.1 - 3.8e-18 65.2 0.0 6.1e-18 64.6 0.0 1.2 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO18301.1 - 0.00048 19.0 0.6 0.00091 18.1 0.6 1.5 1 0 0 1 1 1 1 Sulfate permease family MIG-14_Wnt-bd PF06664.12 ETO18301.1 - 0.036 13.3 0.3 0.058 12.6 0.3 1.2 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Pkinase_Tyr PF07714.17 ETO18303.1 - 2.3e-43 148.4 0.8 4.2e-29 101.6 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO18303.1 - 3.9e-39 134.6 0.5 3.6e-28 98.7 0.1 3.1 3 0 0 3 3 3 3 Protein kinase domain KASH_CCD PF14662.6 ETO18305.1 - 0.0098 15.7 23.9 0.0098 15.7 23.9 5.9 4 1 2 6 6 6 2 Coiled-coil region of CCDC155 or KASH EF-hand_7 PF13499.6 ETO18306.1 - 8.1e-08 32.6 9.1 2.3e-05 24.8 0.1 4.3 4 0 0 4 4 4 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO18306.1 - 9.5e-07 28.6 0.7 0.0062 16.4 0.1 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO18306.1 - 0.00066 19.0 16.2 0.0074 15.8 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ETO18306.1 - 0.0015 18.3 12.6 0.15 12.1 0.1 4.6 5 0 0 5 5 5 3 EF-hand domain EF-hand_5 PF13202.6 ETO18306.1 - 8.8 6.0 17.9 0.11 12.0 0.3 4.7 5 0 0 5 5 5 0 EF hand NKAIN PF05640.14 ETO18307.1 - 0.0047 16.2 7.4 0.0057 15.9 7.4 1.1 1 0 0 1 1 1 1 Na,K-Atpase Interacting protein DUF1449 PF07290.11 ETO18307.1 - 5.7 6.5 6.8 43 3.6 4.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1449) SPESP1 PF15754.5 ETO18308.1 - 0.0044 16.3 3.4 0.0055 15.9 3.4 1.3 1 0 0 1 1 1 1 Sperm equatorial segment protein 1 Mucin PF01456.17 ETO18308.1 - 0.06 13.3 15.1 0.11 12.5 15.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein TFIIA PF03153.13 ETO18308.1 - 0.79 9.6 11.0 0.89 9.5 11.0 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ABC_tran PF00005.27 ETO18309.1 - 7.8e-28 97.7 0.0 5e-27 95.1 0.0 2.4 1 1 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO18309.1 - 3.1e-07 30.1 0.6 1.1e-05 25.0 0.1 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETO18309.1 - 0.0029 18.0 0.1 0.011 16.1 0.2 2.0 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO18309.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ETO18309.1 - 0.082 12.9 0.1 1.5 8.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO18309.1 - 0.13 12.5 1.2 1.1 9.5 0.0 2.7 2 1 1 3 3 3 0 AAA domain PsiE PF06146.12 ETO18309.1 - 0.36 11.2 0.1 0.36 11.2 0.1 1.8 2 0 0 2 2 2 0 Phosphate-starvation-inducible E ABC_membrane PF00664.23 ETO18310.1 - 9e-17 61.6 0.1 1.1e-16 61.3 0.1 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF5533 PF17685.1 ETO18310.1 - 0.034 14.5 0.9 0.049 14.0 0.2 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5533) DUF1190 PF06693.11 ETO18310.1 - 0.093 13.1 0.2 0.13 12.6 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1190) Pkinase PF00069.25 ETO18311.1 - 6.3e-29 101.1 0.0 8.7e-29 100.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18311.1 - 2.7e-09 36.7 0.0 3.7e-09 36.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DcrB PF08786.11 ETO18311.1 - 0.039 14.1 0.2 0.056 13.5 0.2 1.2 1 0 0 1 1 1 0 DcrB DUF787 PF05619.11 ETO18311.1 - 0.11 11.7 0.1 0.14 11.3 0.1 1.1 1 0 0 1 1 1 0 Borrelia burgdorferi protein of unknown function (DUF787) VbhA PF18495.1 ETO18312.1 - 0.063 13.2 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 Antitoxin VbhA TFIIA PF03153.13 ETO18314.1 - 0.2 11.6 30.7 0.24 11.3 30.7 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF3458 PF11940.8 ETO18315.1 - 0.0098 16.3 0.1 0.025 15.0 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3458) Ig-like fold Ank_2 PF12796.7 ETO18315.1 - 0.064 13.8 0.0 0.19 12.3 0.0 2.1 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO18315.1 - 0.07 13.7 0.1 1.6 9.4 0.0 2.7 1 1 1 2 2 2 0 Ankyrin repeats (many copies) Clathrin PF00637.20 ETO18318.1 - 0.0075 16.2 0.9 0.012 15.5 0.9 1.3 1 0 0 1 1 1 1 Region in Clathrin and VPS DUF3439 PF11921.8 ETO18319.1 - 0.14 12.1 17.8 0.44 10.5 17.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) GIDA PF01134.22 ETO18319.1 - 0.38 9.8 10.2 0.012 14.7 3.4 2.0 1 1 0 1 1 1 0 Glucose inhibited division protein A CH_2 PF06294.11 ETO18319.1 - 6.3 7.0 10.4 3.6 7.8 3.0 2.5 1 1 1 2 2 2 0 CH-like domain in sperm protein RasGEF PF00617.19 ETO18320.1 - 2.3e-26 93.1 3.0 4.4e-26 92.2 1.9 2.1 2 0 0 2 2 2 1 RasGEF domain PUB PF09409.10 ETO18320.1 - 4.3e-09 36.2 0.0 1.8e-08 34.2 0.0 2.0 1 0 0 1 1 1 1 PUB domain RasGEF_N PF00618.20 ETO18320.1 - 0.00014 22.1 7.1 0.00063 19.9 7.1 2.2 1 1 0 1 1 1 1 RasGEF N-terminal motif 7TM_GPCR_Srsx PF10320.9 ETO18320.1 - 0.0067 15.8 0.3 0.012 15.0 0.3 1.4 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srsx TMA7 PF09072.10 ETO18320.1 - 0.44 11.4 6.2 0.36 11.7 2.3 2.4 2 0 0 2 2 2 0 Translation machinery associated TMA7 COMPASS-Shg1 PF05205.12 ETO18320.1 - 1.4 9.6 6.4 6.9 7.4 0.1 2.8 3 0 0 3 3 3 0 COMPASS (Complex proteins associated with Set1p) component shg1 CDC45 PF02724.14 ETO18321.1 - 0.66 8.2 4.8 0.78 8.0 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein USP7_C2 PF14533.6 ETO18322.1 - 0.086 12.5 1.5 1 9.0 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin-specific protease C-terminal DUF3439 PF11921.8 ETO18322.1 - 3.2 7.8 9.5 1.2 9.1 5.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF4746 PF15928.5 ETO18323.1 - 0.13 11.7 9.8 0.18 11.2 9.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Menin PF05053.13 ETO18323.1 - 0.42 8.9 22.9 0.56 8.5 22.9 1.1 1 0 0 1 1 1 0 Menin Striatin PF08232.12 ETO18323.1 - 0.62 10.6 35.3 0.26 11.9 22.0 2.2 1 1 1 2 2 2 0 Striatin family ERM PF00769.19 ETO18323.1 - 2 8.2 32.4 2.8 7.7 32.4 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family V_ATPase_I PF01496.19 ETO18323.1 - 2.1 6.2 20.9 2.7 5.8 20.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 ETO18323.1 - 2.2 7.0 24.5 3.1 6.5 24.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Macoilin PF09726.9 ETO18323.1 - 3.8 5.9 25.8 5.8 5.4 25.8 1.2 1 0 0 1 1 1 0 Macoilin family DUF2370 PF10176.9 ETO18323.1 - 4.4 6.9 10.1 0.33 10.6 4.6 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2370) DUF1664 PF07889.12 ETO18323.1 - 7.3 6.7 12.8 6.8 6.8 3.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) RRN3 PF05327.11 ETO18325.1 - 0.0021 16.7 0.3 0.0022 16.6 0.3 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Pex26 PF07163.12 ETO18325.1 - 0.034 13.5 0.1 0.046 13.0 0.1 1.1 1 0 0 1 1 1 0 Pex26 protein Folate_carrier PF01770.18 ETO18325.1 - 0.14 10.9 0.4 0.18 10.5 0.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier Presenilin PF01080.17 ETO18325.1 - 0.19 10.5 0.1 0.2 10.4 0.1 1.2 1 0 0 1 1 1 0 Presenilin Caskin-Pro-rich PF16907.5 ETO18326.1 - 0.13 12.8 4.5 0.17 12.4 1.3 2.1 2 0 0 2 2 2 0 Proline rich region of Caskin proteins Menin PF05053.13 ETO18326.1 - 0.34 9.2 5.0 0.39 9.0 5.0 1.0 1 0 0 1 1 1 0 Menin AJAP1_PANP_C PF15298.6 ETO18326.1 - 1.7 8.8 17.5 2.6 8.2 17.5 1.3 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DDE_Tnp_1 PF01609.21 ETO18327.1 - 4.3e-17 62.5 0.1 5.7e-17 62.1 0.1 1.2 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1_4 PF13701.6 ETO18327.1 - 0.00076 17.9 0.6 0.0019 16.6 0.6 1.6 1 1 0 1 1 1 1 Transposase DDE domain group 1 DDE_Tnp_2 PF04693.12 ETO18327.1 - 0.00088 18.6 0.2 0.0017 17.7 0.2 1.4 1 0 0 1 1 1 1 Archaeal putative transposase ISC1217 DUF4372 PF14294.6 ETO18327.1 - 0.0062 16.7 0.1 0.022 14.9 0.1 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4372) Aldo_ket_red PF00248.21 ETO18328.1 - 9.8e-37 126.7 0.0 2.2e-36 125.6 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family WD40 PF00400.32 ETO18329.1 - 1.7e-26 91.9 22.4 4.7e-06 27.2 0.1 5.6 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18329.1 - 5.6e-11 42.6 0.5 0.009 16.3 0.0 4.1 2 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18329.1 - 5e-06 25.5 1.4 0.55 8.8 0.0 3.9 2 2 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO18329.1 - 0.0017 17.8 7.7 0.012 15.0 3.1 3.4 1 1 3 4 4 4 1 WD40-like domain HARP PF07443.13 ETO18329.1 - 0.0029 17.2 0.0 1.8 8.3 0.0 3.5 3 0 0 3 3 3 1 HepA-related protein (HARP) GMC_oxred_N PF00732.19 ETO18330.1 - 0.063 12.6 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 GMC oxidoreductase MinE PF03776.14 ETO18331.1 - 0.039 14.0 0.4 13 5.9 0.0 3.3 3 0 0 3 3 3 0 Septum formation topological specificity factor MinE Tautomerase_2 PF14552.6 ETO18331.1 - 0.1 12.7 0.0 0.46 10.6 0.0 2.1 2 0 0 2 2 2 0 Tautomerase enzyme Xrn1_D3 PF18194.1 ETO18331.1 - 0.14 12.2 1.9 0.46 10.6 0.0 2.6 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 SHE3 PF17078.5 ETO18333.1 - 0.0062 16.3 4.3 0.0081 15.9 4.3 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 DUF4250 PF14056.6 ETO18333.1 - 0.026 14.5 0.5 0.4 10.7 0.0 2.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4250) Csm1_N PF18504.1 ETO18333.1 - 0.029 14.7 1.4 0.029 14.7 1.4 1.9 2 0 0 2 2 2 0 Csm1 N-terminal domain DHHA1 PF02272.19 ETO18333.1 - 0.11 13.0 0.1 0.17 12.3 0.1 1.4 1 0 0 1 1 1 0 DHHA1 domain FapA PF03961.13 ETO18333.1 - 0.22 10.1 4.6 0.25 9.9 4.6 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Jnk-SapK_ap_N PF09744.9 ETO18333.1 - 1.4 9.1 10.3 3.6 7.8 4.7 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4400 PF14348.6 ETO18334.1 - 3.7 7.0 5.8 4.9 6.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) ASD2 PF08687.11 ETO18334.1 - 7.4 6.0 12.9 9.5 5.7 12.9 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 MoCF_biosynth PF00994.24 ETO18335.1 - 9.6e-18 64.2 0.0 1e-17 64.1 0.0 1.0 1 0 0 1 1 1 1 Probable molybdopterin binding domain tRNA-synt_2b PF00587.25 ETO18337.1 - 4.6e-11 43.0 0.0 2.3e-09 37.5 0.0 2.2 1 1 1 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) FAM176 PF14851.6 ETO18339.1 - 0.62 9.7 5.9 1.1 8.9 5.9 1.4 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO18339.1 - 3.9 6.7 8.9 5.4 6.2 8.9 1.2 1 0 0 1 1 1 0 NOA36 protein TPR_12 PF13424.6 ETO18340.1 - 1.7e-13 50.6 4.4 3e-10 40.3 3.1 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18340.1 - 1.1e-09 37.6 3.0 0.0088 16.1 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18340.1 - 5.3e-09 35.6 3.7 0.13 12.5 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18340.1 - 2.6e-08 33.3 1.4 0.4 10.6 0.0 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO18340.1 - 9.2e-06 25.3 5.2 0.00038 19.9 1.6 2.0 1 1 0 2 2 2 2 MalT-like TPR region TPR_7 PF13176.6 ETO18340.1 - 2.6e-05 23.9 2.9 0.48 10.6 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18340.1 - 0.0015 19.2 3.2 5.8 8.0 0.2 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO18340.1 - 0.0017 18.2 2.7 0.27 11.2 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO18340.1 - 0.0033 18.1 2.6 0.52 11.0 0.5 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18340.1 - 0.054 14.1 2.7 27 5.7 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO18340.1 - 0.42 11.2 4.6 5.3 7.6 0.2 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat RhoGEF PF00621.20 ETO18342.1 - 3.1e-20 73.2 0.1 3.1e-20 73.2 0.1 1.6 2 0 0 2 2 2 1 RhoGEF domain CDC45 PF02724.14 ETO18342.1 - 0.021 13.2 10.4 0.027 12.8 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF737 PF05300.11 ETO18342.1 - 0.087 13.2 15.4 0.12 12.7 15.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF737) HeLo PF14479.6 ETO18342.1 - 0.12 12.2 5.7 0.16 11.8 5.7 1.2 1 0 0 1 1 1 0 Prion-inhibition and propagation Peptidase_S64 PF08192.11 ETO18342.1 - 0.17 10.4 2.9 0.22 10.0 2.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF2828 PF11443.8 ETO18342.1 - 0.31 9.1 9.4 0.43 8.6 9.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Exonuc_VII_L PF02601.15 ETO18342.1 - 0.92 9.0 5.9 1.2 8.7 5.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit MDM10 PF12519.8 ETO18342.1 - 1.1 8.0 5.8 1.4 7.7 5.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DDRGK PF09756.9 ETO18342.1 - 1.3 8.5 25.0 1.9 8.0 25.0 1.2 1 0 0 1 1 1 0 DDRGK domain RR_TM4-6 PF06459.12 ETO18342.1 - 1.4 8.7 11.9 1.9 8.2 11.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO18342.1 - 1.4 7.6 7.5 1.7 7.3 7.5 1.1 1 0 0 1 1 1 0 Presenilin HSP70 PF00012.20 ETO18342.1 - 1.9 6.6 6.3 2.1 6.4 6.3 1.1 1 0 0 1 1 1 0 Hsp70 protein Neur_chan_memb PF02932.16 ETO18342.1 - 2.1 8.4 3.6 3.3 7.7 3.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Mitofilin PF09731.9 ETO18342.1 - 2.7 6.7 17.4 3.5 6.3 17.4 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF5401 PF17380.2 ETO18342.1 - 4.9 5.1 22.0 6 4.8 22.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) DUF2058 PF09831.9 ETO18342.1 - 6.1 7.0 16.3 10 6.2 16.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) ADP_ribosyl_GH PF03747.14 ETO18343.1 - 7.3e-16 58.7 0.0 8.2e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase WD40 PF00400.32 ETO18344.1 - 1.4e-10 41.6 12.0 0.0011 19.8 0.4 4.0 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18344.1 - 0.00017 21.8 0.3 0.94 9.8 0.0 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18344.1 - 0.00052 18.8 3.4 0.21 10.2 1.5 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO18344.1 - 0.15 12.4 3.4 0.82 10.1 0.1 3.0 3 1 0 3 3 3 0 Kelch motif DUF4101 PF13355.6 ETO18345.1 - 0.079 13.4 3.8 0.077 13.4 3.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4101) Spore_III_AF PF09581.10 ETO18345.1 - 0.54 10.3 12.7 1 9.4 12.7 1.5 1 1 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) DUF2457 PF10446.9 ETO18345.1 - 0.79 8.8 20.5 0.77 8.8 20.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CNDH2_C PF16858.5 ETO18345.1 - 1.1 9.1 15.6 1.3 8.9 15.6 1.0 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Pox_Ag35 PF03286.14 ETO18345.1 - 1.7 8.4 15.5 2.1 8.1 15.5 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO18345.1 - 1.8 7.8 20.7 1.9 7.7 20.7 1.1 1 0 0 1 1 1 0 NOA36 protein Vfa1 PF08432.10 ETO18345.1 - 5.3 7.3 16.5 6.4 7.1 16.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2076 PF09849.9 ETO18345.1 - 6.3 6.8 16.2 6.4 6.7 16.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) putAbiC PF16872.5 ETO18346.1 - 0.0078 16.9 2.4 0.037 14.7 2.4 2.3 1 1 0 1 1 1 1 Putative phage abortive infection protein THAP PF05485.12 ETO18346.1 - 0.09 13.7 0.8 0.09 13.7 0.8 2.7 2 1 0 2 2 2 0 THAP domain CLN3 PF02487.17 ETO18346.1 - 3.5 6.6 12.5 4 6.4 0.9 2.2 2 0 0 2 2 2 0 CLN3 protein Phytochelatin PF05023.14 ETO18348.1 - 0.096 11.9 1.7 6.6 5.9 0.0 2.5 2 1 0 2 2 2 0 Phytochelatin synthase DUF4250 PF14056.6 ETO18348.1 - 0.33 10.9 6.7 9.5 6.3 0.6 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) Thioredoxin_8 PF13905.6 ETO18348.1 - 3.6 8.0 8.0 2.1 8.7 1.1 2.7 1 1 1 2 2 2 0 Thioredoxin-like Peptidase_C54 PF03416.19 ETO18349.1 - 3.8e-37 128.2 0.1 4.3e-37 128.0 0.1 1.0 1 0 0 1 1 1 1 Peptidase family C54 7TM_GPCR_Sru PF10322.9 ETO18350.1 - 0.00048 19.6 6.5 0.11 11.8 0.2 2.1 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Sru RexB PF15968.5 ETO18350.1 - 0.0012 19.3 0.1 0.0015 19.0 0.1 1.1 1 0 0 1 1 1 1 Membrane-anchored ion channel, Abi component 2HCT PF03390.15 ETO18350.1 - 0.0038 15.9 0.2 0.0041 15.8 0.2 1.1 1 0 0 1 1 1 1 2-hydroxycarboxylate transporter family RAMP4 PF06624.12 ETO18350.1 - 0.057 13.5 4.0 0.063 13.3 0.1 2.9 3 1 0 3 3 3 0 Ribosome associated membrane protein RAMP4 GWT1 PF06423.12 ETO18350.1 - 0.067 13.3 1.1 0.11 12.6 1.1 1.4 1 1 0 1 1 1 0 GWT1 DUF2663 PF10864.8 ETO18350.1 - 0.79 10.1 6.6 0.097 13.1 1.8 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) Ras PF00071.22 ETO18351.1 - 3.5e-07 30.0 0.0 4.6e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO18351.1 - 9.5e-07 29.1 0.5 2.4e-06 27.8 0.5 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ETO18351.1 - 2.9e-05 23.4 1.0 3.4e-05 23.2 1.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_7 PF12775.7 ETO18351.1 - 0.015 14.8 0.1 0.021 14.3 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TniB PF05621.11 ETO18351.1 - 0.043 13.2 0.0 0.058 12.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA_19 PF13245.6 ETO18351.1 - 0.16 12.3 0.3 0.21 11.9 0.3 1.4 1 1 0 1 1 1 0 AAA domain UBM PF14377.6 ETO18352.1 - 0.00072 18.9 1.0 0.00072 18.9 1.0 3.8 4 0 0 4 4 4 1 Ubiquitin binding region DUF966 PF06136.13 ETO18352.1 - 1.6 8.4 10.2 2.6 7.7 10.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) HECT PF00632.25 ETO18353.1 - 2.2e-89 300.0 0.5 5.9e-89 298.6 0.5 1.8 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) CPSF100_C PF13299.6 ETO18353.1 - 0.049 13.8 6.2 0.32 11.2 0.1 2.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ALMT PF11744.8 ETO18353.1 - 2.3 6.9 12.1 0.46 9.3 6.4 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter TPR_2 PF07719.17 ETO18354.1 - 0.018 15.1 3.9 0.071 13.3 0.3 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18354.1 - 0.025 15.2 0.3 2 9.2 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat SesA PF17107.5 ETO18354.1 - 0.055 13.7 0.4 2 8.6 0.0 2.7 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_12 PF13424.6 ETO18354.1 - 0.98 9.8 3.4 14 6.1 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF848 PF05852.11 ETO18354.1 - 1.4 9.0 4.3 0.75 9.9 0.9 2.2 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) DUF3347 PF11827.8 ETO18354.1 - 1.8 8.7 7.1 0.19 11.9 1.5 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3347) TPR_2 PF07719.17 ETO18355.1 - 2.6e-09 36.5 4.4 2 8.7 0.5 6.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO18355.1 - 3.5e-06 27.2 2.4 3.2 8.1 0.2 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO18355.1 - 0.00047 20.3 1.7 1.6 8.9 0.1 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18355.1 - 0.00054 19.7 11.5 5.6 7.0 0.1 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18355.1 - 0.00083 19.4 9.5 16 6.0 0.0 5.9 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18355.1 - 0.0017 18.2 2.3 3.2 8.0 0.0 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18355.1 - 0.055 14.1 6.5 79 4.2 0.4 6.3 6 1 0 6 6 6 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ETO18355.1 - 0.1 12.6 4.3 0.17 11.9 0.7 3.0 2 0 0 2 2 2 0 Putative TPR-like repeat GlcNAc PF11397.8 ETO18357.1 - 4.7e-46 157.9 1.0 8e-40 137.4 1.2 2.1 1 1 1 2 2 2 2 Glycosyltransferase (GlcNAc) Glyco_trans_2_3 PF13632.6 ETO18357.1 - 0.026 14.4 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family group 2 Stk19 PF10494.9 ETO18358.1 - 2.3e-15 56.9 5.1 1.1e-13 51.4 0.2 2.9 3 1 0 3 3 3 2 Serine-threonine protein kinase 19 DUF3464 PF11947.8 ETO18358.1 - 1.1 9.0 3.5 2.3 8.0 3.5 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 U1snRNP70_N PF12220.8 ETO18358.1 - 3.9 8.2 9.7 11 6.7 9.7 1.8 1 0 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal FAM176 PF14851.6 ETO18358.1 - 5 6.8 9.4 0.58 9.8 4.9 1.7 2 0 0 2 2 2 0 FAM176 family PWWP PF00855.17 ETO18359.1 - 4.3e-06 27.0 0.0 1.1e-05 25.8 0.0 1.8 1 1 0 1 1 1 1 PWWP domain TTL PF03133.15 ETO18361.1 - 1.6e-62 211.3 8.1 4.1e-44 150.9 3.7 2.4 2 1 0 2 2 2 2 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ETO18361.1 - 5.6e-08 32.3 0.1 0.0074 15.6 0.0 2.5 2 0 0 2 2 2 2 YheC/D like ATP-grasp S1FA PF04689.13 ETO18361.1 - 0.099 12.8 1.1 0.24 11.6 1.1 1.6 1 0 0 1 1 1 0 DNA binding protein S1FA CSD PF00313.22 ETO18362.1 - 2e-08 33.9 0.8 7.1e-06 25.8 0.0 4.0 4 0 0 4 4 4 2 'Cold-shock' DNA-binding domain tRNA-synt_1g PF09334.11 ETO18364.1 - 9.3e-38 130.0 1.2 2.8e-21 75.7 0.1 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ETO18364.1 - 0.0031 15.8 0.2 0.58 8.3 0.0 2.4 1 1 2 3 3 3 2 tRNA synthetases class I (I, L, M and V) YL1_C PF08265.11 ETO18364.1 - 0.22 11.3 0.8 0.54 10.1 0.3 1.9 2 0 0 2 2 2 0 YL1 nuclear protein C-terminal domain Arm PF00514.23 ETO18365.1 - 1.4e-09 37.7 0.8 0.016 15.3 0.1 3.3 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat PI3_PI4_kinase PF00454.27 ETO18366.1 - 4.1e-06 26.8 2.6 4.5e-06 26.7 0.0 2.1 2 1 1 3 3 3 1 Phosphatidylinositol 3- and 4-kinase SYCP2_ARLD PF18581.1 ETO18366.1 - 0.018 15.1 3.4 3.7 7.5 0.8 2.8 1 1 2 3 3 3 0 Synaptonemal complex 2 armadillo-repeat-like domain DUF1190 PF06693.11 ETO18367.1 - 0.15 12.4 0.0 0.18 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1190) zf-C3HC4_3 PF13920.6 ETO18368.1 - 0.00027 20.7 15.9 0.00046 20.0 15.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO18368.1 - 0.00093 19.5 20.7 0.0016 18.7 20.7 1.4 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO18368.1 - 0.002 17.9 19.9 0.0035 17.2 19.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ETO18368.1 - 0.0031 17.3 6.1 0.0053 16.6 6.1 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein CcmH PF03918.14 ETO18368.1 - 0.087 12.1 1.5 9.5 5.5 0.4 2.5 2 0 0 2 2 2 0 Cytochrome C biogenesis protein zf-C3HC4_4 PF15227.6 ETO18368.1 - 1.1 9.4 15.6 5.4 7.3 16.0 1.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETO18368.1 - 1.1 9.1 16.4 3 7.8 16.4 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Vps39_2 PF10367.9 ETO18368.1 - 5 7.6 12.8 20 5.7 8.3 2.5 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 DUF4205 PF13898.6 ETO18369.1 - 8.1e-24 84.2 0.0 3.4e-23 82.2 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4205) Augurin PF15187.6 ETO18369.1 - 0.12 12.5 0.9 0.57 10.4 0.2 2.0 2 0 0 2 2 2 0 Oesophageal cancer-related gene 4 CDC45 PF02724.14 ETO18370.1 - 0.051 11.9 8.0 0.067 11.5 8.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Smg8_Smg9 PF10220.9 ETO18370.1 - 0.55 8.5 6.1 0.66 8.2 6.1 1.1 1 0 0 1 1 1 0 Smg8_Smg9 Apt1 PF10351.9 ETO18370.1 - 3.4 6.4 11.9 4 6.2 11.9 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain NPR3 PF03666.13 ETO18370.1 - 5.4 5.7 12.7 7.1 5.3 12.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GIT_CC PF16559.5 ETO18371.1 - 0.044 13.7 0.1 0.089 12.7 0.1 1.5 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor CSTF2_hinge PF14327.6 ETO18371.1 - 0.1 13.1 0.4 0.18 12.3 0.4 1.4 1 0 0 1 1 1 0 Hinge domain of cleavage stimulation factor subunit 2 AA_permease PF00324.21 ETO18372.1 - 5.8e-25 87.8 22.7 7.2e-25 87.5 22.7 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETO18372.1 - 0.00038 19.4 22.8 0.00038 19.4 22.8 1.6 1 1 1 2 2 2 1 Amino acid permease FA_desaturase PF00487.24 ETO18372.1 - 0.0067 16.3 5.4 1.8 8.3 0.0 2.2 1 1 1 2 2 2 2 Fatty acid desaturase DUF2207 PF09972.9 ETO18372.1 - 3.5 6.3 15.5 1.2e+03 -2.1 15.5 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF1616 PF07760.11 ETO18372.1 - 3.6 6.9 6.5 31 3.8 6.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1616) CDC45 PF02724.14 ETO18375.1 - 4.8 5.3 18.9 6.8 4.9 18.9 1.3 1 0 0 1 1 1 0 CDC45-like protein NUDIX PF00293.28 ETO18376.1 - 8.7e-16 58.2 0.0 2e-15 57.0 0.0 1.6 1 0 0 1 1 1 1 NUDIX domain UCH PF00443.29 ETO18377.1 - 1.1e-38 133.2 0.6 1.6e-24 86.8 0.0 2.8 3 0 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO18377.1 - 8.9e-20 71.5 4.1 6e-11 42.5 0.0 3.5 3 1 0 3 3 3 2 Ubiquitin carboxyl-terminal hydrolase UN_NPL4 PF11543.8 ETO18377.1 - 6.7e-05 23.3 0.3 0.01 16.3 0.0 3.3 3 0 0 3 3 3 1 Nuclear pore localisation protein NPL4 Ubiquitin_2 PF14560.6 ETO18377.1 - 0.0045 17.4 0.1 0.04 14.4 0.0 2.6 2 0 0 2 2 2 1 Ubiquitin-like domain CtnDOT_TraJ PF07863.11 ETO18377.1 - 0.025 15.2 2.4 0.069 13.8 2.4 1.7 1 0 0 1 1 1 0 Homologues of TraJ from Bacteroides conjugative transposon ubiquitin PF00240.23 ETO18377.1 - 0.096 12.5 0.0 0.39 10.5 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin family Nop14 PF04147.12 ETO18378.1 - 0.00037 18.9 14.6 0.00049 18.5 14.6 1.3 1 0 0 1 1 1 1 Nop14-like family Presenilin PF01080.17 ETO18378.1 - 0.016 14.0 13.7 0.023 13.5 13.7 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO18378.1 - 0.035 12.4 16.4 0.048 12.0 16.4 1.3 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 ETO18378.1 - 0.39 9.2 14.8 0.48 8.9 14.8 1.1 1 0 0 1 1 1 0 Macoilin family CAC1F_C PF16885.5 ETO18378.1 - 0.56 9.8 9.7 0.78 9.3 9.7 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Apis_Csd PF11671.8 ETO18378.1 - 8.1 6.4 22.4 5 7.1 19.3 2.3 2 0 0 2 2 2 0 Complementary sex determiner protein Cytomega_UL84 PF06284.11 ETO18378.1 - 10 4.5 10.6 15 3.9 10.6 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF2681 PF10883.8 ETO18379.1 - 1.7 9.1 5.2 6.5 7.2 0.2 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Ank_2 PF12796.7 ETO18381.1 - 0.027 15.1 0.0 0.081 13.5 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO18381.1 - 0.042 14.2 0.1 0.12 12.7 0.1 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) DUF4898 PF16239.5 ETO18381.1 - 0.11 12.5 1.5 0.4 10.7 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4898) ETRAMP PF09716.10 ETO18381.1 - 0.2 11.7 3.1 0.48 10.5 1.4 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SR-25 PF10500.9 ETO18381.1 - 8.3 5.9 18.3 0.013 15.1 6.2 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein BTB_2 PF02214.22 ETO18382.1 - 7.3e-06 26.3 1.3 0.00013 22.2 0.1 2.9 3 0 0 3 3 3 1 BTB/POZ domain FF PF01846.19 ETO18382.1 - 0.077 13.2 0.0 0.31 11.2 0.0 2.1 1 0 0 1 1 1 0 FF domain RNA_pol_3_Rpc31 PF11705.8 ETO18382.1 - 0.2 11.9 8.9 0.018 15.3 2.5 2.4 3 0 0 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 DUF2076 PF09849.9 ETO18382.1 - 1.4 8.9 11.6 5.2 7.0 11.6 2.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Peptidase_M10 PF00413.24 ETO18383.1 - 5.8e-19 68.5 0.0 1.5e-18 67.2 0.0 1.7 1 0 0 1 1 1 1 Matrixin PG_binding_1 PF01471.18 ETO18383.1 - 1.5e-17 63.5 0.1 2.9e-17 62.6 0.1 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_2 PF08823.11 ETO18383.1 - 0.0077 16.5 0.1 0.0077 16.5 0.1 1.9 2 0 0 2 2 2 1 Putative peptidoglycan binding domain Reprolysin_3 PF13582.6 ETO18383.1 - 0.013 16.1 0.1 0.039 14.5 0.1 1.9 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like PG_binding_3 PF09374.10 ETO18383.1 - 0.027 14.7 0.0 0.059 13.6 0.0 1.6 1 0 0 1 1 1 0 Predicted Peptidoglycan domain Peptidase_M66 PF10462.9 ETO18383.1 - 0.073 12.0 0.9 0.49 9.3 0.4 2.1 2 0 0 2 2 2 0 Peptidase M66 Vasculin PF15337.6 ETO18383.1 - 0.075 13.9 0.2 0.31 11.9 0.0 2.2 2 0 0 2 2 2 0 Vascular protein family Vasculin-like 1 E1_UFD PF09358.10 ETO18383.1 - 1.1 10.0 4.2 3.2 8.5 1.0 3.0 2 1 1 3 3 3 0 Ubiquitin fold domain Tyrosinase PF00264.20 ETO18384.1 - 4.4e-12 46.8 0.1 4.4e-12 46.8 0.1 3.4 2 2 0 2 2 2 1 Common central domain of tyrosinase GETHR PF05671.11 ETO18384.1 - 0.0037 16.6 1.0 0.0076 15.6 0.8 1.7 1 1 0 1 1 1 1 GETHR pentapeptide repeat (5 copies) DUF2206 PF09971.9 ETO18385.1 - 0.0016 17.2 1.1 0.0018 17.1 1.1 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2206) Coilin_N PF15862.5 ETO18386.1 - 0.0017 18.1 0.2 0.0017 18.1 0.2 3.2 2 2 1 4 4 4 1 Coilin N-terminus UPF0242 PF06785.11 ETO18388.1 - 0.0055 16.8 0.0 0.0076 16.4 0.0 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF2162 PF09930.9 ETO18388.1 - 0.008 15.6 0.4 0.011 15.2 0.4 1.1 1 0 0 1 1 1 1 Predicted transporter (DUF2162) TraQ PF09679.10 ETO18388.1 - 0.046 13.6 0.0 0.078 12.9 0.0 1.4 1 0 0 1 1 1 0 Type-F conjugative transfer system pilin chaperone (TraQ) HupE_UreJ_2 PF13795.6 ETO18388.1 - 0.065 12.9 0.4 0.079 12.6 0.4 1.2 1 0 0 1 1 1 0 HupE / UreJ protein Phage_holin_3_6 PF07332.11 ETO18388.1 - 1 9.5 3.6 2.9 7.9 3.6 1.8 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Helicase_C PF00271.31 ETO18389.1 - 1.3e-25 89.9 0.3 2.3e-25 89.1 0.3 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SRP-alpha_N PF04086.13 ETO18390.1 - 0.19 11.6 26.9 0.25 11.2 26.9 1.4 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal LAP1C PF05609.12 ETO18390.1 - 0.35 9.9 23.6 0.41 9.7 23.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Utp14 PF04615.13 ETO18390.1 - 0.79 8.2 31.7 0.93 8.0 31.7 1.0 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 ETO18390.1 - 8.5 3.3 26.2 9.8 3.1 26.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Kelch_6 PF13964.6 ETO18391.1 - 2.2e-05 24.6 0.4 0.4 11.0 0.0 4.3 3 1 1 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO18391.1 - 3e-05 23.9 0.0 1.3 9.1 0.0 3.6 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO18391.1 - 5.3e-05 22.7 3.0 0.015 14.9 0.1 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO18391.1 - 0.0032 17.7 0.1 0.44 10.9 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain DUF3439 PF11921.8 ETO18392.1 - 0.053 13.5 6.4 0.15 12.0 6.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) zf-C2H2_4 PF13894.6 ETO18393.1 - 0.058 14.3 14.5 0.1 13.5 1.4 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO18393.1 - 3 8.5 14.0 0.51 10.9 2.4 3.6 3 0 0 3 3 3 0 Zinc finger, C2H2 type DUF1088 PF06469.11 ETO18395.1 - 0.0087 15.7 0.2 0.017 14.8 0.2 1.6 1 1 0 1 1 1 1 Domain of Unknown Function (DUF1088) WBP-1 PF11669.8 ETO18395.1 - 0.094 13.4 1.2 0.17 12.5 0.2 1.9 2 0 0 2 2 2 0 WW domain-binding protein 1 O-antigen_lig PF13425.6 ETO18395.1 - 0.13 11.0 0.1 0.18 10.6 0.1 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein TMCO5 PF14992.6 ETO18396.1 - 0.00095 18.8 13.3 0.0011 18.7 13.3 1.2 1 0 0 1 1 1 1 TMCO5 family Leu_zip PF15294.6 ETO18396.1 - 0.0015 18.1 12.5 0.0018 17.8 12.5 1.1 1 0 0 1 1 1 1 Leucine zipper DUF1465 PF07323.12 ETO18396.1 - 0.0053 16.6 4.0 0.0077 16.1 4.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1465) Cauli_AT PF03233.13 ETO18396.1 - 0.0072 16.3 7.2 0.011 15.7 7.2 1.4 1 0 0 1 1 1 1 Aphid transmission protein UPF0449 PF15136.6 ETO18396.1 - 0.008 16.6 9.1 0.008 16.6 9.1 1.6 2 0 0 2 2 1 1 Uncharacterised protein family UPF0449 HrpB7 PF09486.10 ETO18396.1 - 0.01 16.2 4.1 0.016 15.6 4.1 1.2 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) Prominin PF05478.11 ETO18396.1 - 0.023 12.7 9.2 0.026 12.5 9.2 1.0 1 0 0 1 1 1 0 Prominin CENP-R PF06729.12 ETO18396.1 - 0.032 14.2 8.2 0.073 13.0 8.1 1.6 1 1 0 1 1 1 0 Kinetochore component, CENP-R ERM PF00769.19 ETO18396.1 - 0.043 13.6 17.8 0.058 13.2 17.8 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family SlyX PF04102.12 ETO18396.1 - 0.074 13.7 3.4 0.074 13.7 3.4 2.2 1 1 1 2 2 2 0 SlyX DUF2730 PF10805.8 ETO18396.1 - 0.08 13.0 3.6 0.13 12.4 3.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) PA26 PF04636.13 ETO18396.1 - 0.25 10.2 11.7 0.26 10.1 11.7 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF2205 PF10224.9 ETO18396.1 - 0.46 10.5 12.5 1.2 9.2 9.6 2.5 1 1 1 2 2 2 0 Short coiled-coil protein HemX PF04375.14 ETO18396.1 - 0.81 8.9 11.4 1.1 8.5 11.4 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase TMPIT PF07851.13 ETO18396.1 - 0.92 8.7 10.3 1 8.5 10.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein XhlA PF10779.9 ETO18396.1 - 1.1 9.6 10.5 1.3 9.2 9.3 1.8 1 1 0 1 1 1 0 Haemolysin XhlA LCD1 PF09798.9 ETO18396.1 - 1.3 7.4 15.9 1.6 7.1 15.9 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein DUF3450 PF11932.8 ETO18396.1 - 2.2 7.5 12.6 3.3 7.0 12.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DivIC PF04977.15 ETO18396.1 - 3.2 7.6 18.4 0.25 11.1 10.7 2.5 1 1 2 3 3 3 0 Septum formation initiator DUF4407 PF14362.6 ETO18396.1 - 3.9 6.7 10.8 4.3 6.6 10.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LMBR1 PF04791.16 ETO18396.1 - 4.4 6.1 10.5 4.7 6.0 10.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 ETO18396.1 - 4.4 5.1 13.5 5 4.9 13.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family AAA_11 PF13086.6 ETO18396.1 - 4.8 6.9 15.7 4.1 7.1 14.8 1.2 1 1 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 ETO18396.1 - 7.7 6.0 11.4 8.8 5.8 11.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RING_2 PF13639.6 ETO18397.1 - 0.026 14.9 4.7 0.1 12.9 4.7 2.1 1 1 0 1 1 1 0 Ring finger domain zf-rbx1 PF12678.7 ETO18397.1 - 2.5 8.5 7.9 11 6.3 7.9 2.2 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETO18397.1 - 7.5 6.6 7.0 21 5.1 6.3 2.2 1 1 1 2 2 2 0 zinc-RING finger domain PWI PF01480.17 ETO18398.1 - 5.9e-19 68.2 0.4 6.8e-18 64.7 0.0 2.2 1 1 1 2 2 2 1 PWI domain Phage_AlpA PF05930.12 ETO18398.1 - 0.026 14.4 0.0 0.082 12.7 0.0 1.8 2 0 0 2 2 2 0 Prophage CP4-57 regulatory protein (AlpA) Tet_JBP PF12851.7 ETO18400.1 - 0.0053 16.1 0.6 0.0053 16.1 0.6 1.7 1 1 1 2 2 2 1 Oxygenase domain of the 2OGFeDO superfamily Borrelia_P83 PF05262.11 ETO18400.1 - 3 6.2 24.7 3.1 6.2 24.7 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein DUF3464 PF11947.8 ETO18400.1 - 5.2 6.8 21.2 0.55 10.0 3.0 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Amino_oxidase PF01593.24 ETO18401.1 - 2.2e-31 109.6 0.0 2.8e-29 102.7 0.0 2.1 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase MACPF PF01823.19 ETO18401.1 - 0.0077 16.3 8.5 0.087 12.9 0.0 2.3 2 0 0 2 2 2 1 MAC/Perforin domain Presenilin PF01080.17 ETO18401.1 - 1.1 7.9 9.2 0.12 11.1 0.9 2.0 2 0 0 2 2 2 0 Presenilin CDC45 PF02724.14 ETO18401.1 - 1.7 6.8 10.2 0.44 8.8 0.3 2.0 2 0 0 2 2 2 0 CDC45-like protein PRC2_HTH_1 PF18118.1 ETO18401.1 - 7.5 7.4 10.2 3.9 8.3 4.3 2.3 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain zf-ribbon_3 PF13248.6 ETO18403.1 - 0.15 11.5 0.1 0.15 11.5 0.1 2.4 2 0 0 2 2 2 0 zinc-ribbon domain DUF3037 PF11236.8 ETO18403.1 - 0.61 10.5 3.0 0.53 10.7 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) Arc_trans_TRASH PF08394.10 ETO18403.1 - 6 7.3 9.7 1.1 9.7 1.3 3.0 2 0 0 2 2 2 0 Archaeal TRASH domain PIG-L PF02585.17 ETO18404.1 - 0.14 12.8 0.1 0.21 12.2 0.1 1.2 1 0 0 1 1 1 0 GlcNAc-PI de-N-acetylase MscS_TM PF12794.7 ETO18404.1 - 0.19 10.6 0.4 0.28 10.0 0.4 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 OAD_gamma PF04277.13 ETO18404.1 - 0.64 10.7 4.3 0.6 10.7 0.2 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Cauli_AT PF03233.13 ETO18404.1 - 1.4 8.9 14.3 0.16 11.9 9.2 1.9 2 0 0 2 2 2 0 Aphid transmission protein MAJIN PF15077.6 ETO18404.1 - 5.4 6.7 11.3 8.1 6.2 10.8 1.5 1 1 0 1 1 1 0 Membrane-anchored junction protein LRR_6 PF13516.6 ETO18405.1 - 3.2e-08 33.0 14.6 0.046 13.8 0.0 5.7 5 0 0 5 5 5 4 Leucine Rich repeat UPF1_Zn_bind PF09416.10 ETO18406.1 - 6.6e-09 35.9 0.0 1.7e-08 34.6 0.0 1.7 1 0 0 1 1 1 1 RNA helicase (UPF2 interacting domain) PUF PF00806.19 ETO18407.1 - 4.7e-26 89.0 8.2 5.2e-06 25.8 0.1 6.4 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat Utp12 PF04003.12 ETO18407.1 - 0.031 14.6 0.8 0.76 10.1 0.1 2.9 2 1 1 3 3 3 0 Dip2/Utp12 Family NIPSNAP PF07978.13 ETO18408.1 - 0.005 17.0 0.0 0.013 15.7 0.0 1.8 1 0 0 1 1 1 1 NIPSNAP Vps23_core PF09454.10 ETO18408.1 - 0.0067 16.3 0.4 0.28 11.2 0.0 3.4 2 1 1 3 3 3 1 Vps23 core domain ABC_membrane PF00664.23 ETO18411.1 - 8.3e-44 150.3 10.8 1.3e-43 149.6 10.8 1.4 1 1 0 1 1 1 1 ABC transporter transmembrane region SAM_2 PF07647.17 ETO18412.1 - 1.8e-11 44.0 0.1 3.5e-11 43.1 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO18412.1 - 2e-11 44.1 0.1 5.1e-11 42.9 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PH PF00169.29 ETO18412.1 - 6.3e-10 39.5 1.3 6.3e-10 39.5 1.3 2.8 3 0 0 3 3 3 1 PH domain SAM_PNT PF02198.16 ETO18412.1 - 0.017 15.1 0.0 0.044 13.8 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain PH_8 PF15409.6 ETO18412.1 - 0.025 14.8 0.1 0.025 14.8 0.1 2.8 3 0 0 3 3 3 0 Pleckstrin homology domain RNase_PH_C PF03725.15 ETO18413.1 - 2.7e-12 46.5 0.0 4.5e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 RNase_PH PF01138.21 ETO18413.1 - 0.0022 18.5 0.1 0.012 16.1 0.0 2.1 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 PNPase PF03726.14 ETO18413.1 - 0.032 14.7 0.0 0.076 13.5 0.0 1.8 1 1 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain CIDE-N PF02017.15 ETO18413.1 - 0.045 13.8 0.0 0.095 12.7 0.0 1.5 1 0 0 1 1 1 0 CIDE-N domain Terminase_4 PF05119.12 ETO18413.1 - 0.062 13.7 0.3 5 7.6 0.0 2.3 1 1 2 3 3 3 0 Phage terminase, small subunit YqfQ PF14181.6 ETO18416.1 - 0.009 16.2 0.3 0.009 16.2 0.3 2.8 3 0 0 3 3 3 1 YqfQ-like protein DUF3813 PF12758.7 ETO18416.1 - 0.27 11.6 0.2 0.27 11.6 0.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3813) Noggin PF05806.12 ETO18416.1 - 0.35 10.7 6.6 0.063 13.2 0.9 2.1 2 0 0 2 2 2 0 Noggin Zip PF02535.22 ETO18417.1 - 0.00043 19.6 1.0 0.00043 19.6 1.0 1.8 2 0 0 2 2 2 1 ZIP Zinc transporter ASD2 PF08687.11 ETO18417.1 - 1.8 8.0 7.7 0.049 13.2 1.4 1.5 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 BAF1_ABF1 PF04684.13 ETO18417.1 - 2.5 7.1 29.9 0.14 11.2 14.2 2.0 2 0 0 2 2 2 0 BAF1 / ABF1 chromatin reorganising factor ALMT PF11744.8 ETO18417.1 - 5 5.8 15.6 0.23 10.2 6.9 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter Neur_chan_memb PF02932.16 ETO18418.1 - 0.018 15.1 2.2 0.021 14.9 2.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LMBR1 PF04791.16 ETO18418.1 - 0.06 12.2 1.4 0.071 12.0 1.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CDC45 PF02724.14 ETO18418.1 - 0.2 9.9 9.3 0.22 9.8 9.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.6 ETO18418.1 - 0.2 10.4 7.0 0.22 10.2 7.0 1.0 1 0 0 1 1 1 0 Raftlin MTBP_C PF14920.6 ETO18418.1 - 0.71 9.6 8.3 0.84 9.3 8.3 1.1 1 0 0 1 1 1 0 MDM2-binding Presenilin PF01080.17 ETO18418.1 - 6.5 5.4 7.8 6.8 5.3 7.8 1.2 1 0 0 1 1 1 0 Presenilin AAA_18 PF13238.6 ETO18419.1 - 4.5e-07 30.5 4.8 7.9e-07 29.7 4.8 1.7 1 1 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ETO18419.1 - 6.2e-07 29.9 0.0 0.00055 20.4 0.0 2.1 2 0 0 2 2 2 2 AAA domain ABC_tran PF00005.27 ETO18419.1 - 3.1e-05 24.5 0.3 4.4e-05 24.0 0.3 1.2 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 ETO18419.1 - 3.8e-05 23.9 0.1 7.3e-05 22.9 0.1 1.6 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO18419.1 - 8.3e-05 22.9 2.0 0.0073 16.7 1.5 2.9 2 1 0 2 2 2 1 RNA helicase ATP_bind_1 PF03029.17 ETO18419.1 - 0.00062 19.6 0.0 0.0012 18.7 0.0 1.4 1 0 0 1 1 1 1 Conserved hypothetical ATP binding protein NACHT PF05729.12 ETO18419.1 - 0.0007 19.6 0.0 0.0015 18.5 0.0 1.6 2 0 0 2 2 2 1 NACHT domain Viral_helicase1 PF01443.18 ETO18419.1 - 0.001 18.9 0.0 0.002 17.9 0.0 1.5 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 ETO18419.1 - 0.0022 17.2 0.0 0.0038 16.5 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_19 PF13245.6 ETO18419.1 - 0.0026 18.1 0.0 0.0046 17.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO18419.1 - 0.0045 17.4 0.0 0.0062 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain ADK PF00406.22 ETO18419.1 - 0.0066 16.6 0.0 0.25 11.4 0.0 2.1 2 0 0 2 2 2 1 Adenylate kinase FtsK_SpoIIIE PF01580.18 ETO18419.1 - 0.0068 15.8 0.0 0.013 14.9 0.0 1.4 1 0 0 1 1 1 1 FtsK/SpoIIIE family AAA_29 PF13555.6 ETO18419.1 - 0.0079 15.9 0.0 0.03 14.1 0.0 1.9 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO18419.1 - 0.0083 16.4 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 ETO18419.1 - 0.013 15.1 0.0 0.022 14.4 0.0 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain AAA_14 PF13173.6 ETO18419.1 - 0.014 15.5 0.3 0.051 13.6 0.3 2.0 1 1 0 1 1 1 0 AAA domain Ploopntkinase3 PF18751.1 ETO18419.1 - 0.015 15.2 0.0 0.021 14.8 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA PF00004.29 ETO18419.1 - 0.016 15.7 0.0 0.039 14.4 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ETO18419.1 - 0.017 15.0 0.0 0.038 13.9 0.0 1.6 1 0 0 1 1 1 0 NTPase Zeta_toxin PF06414.12 ETO18419.1 - 0.02 14.2 0.0 0.12 11.6 0.0 2.0 2 0 0 2 2 2 0 Zeta toxin RsgA_GTPase PF03193.16 ETO18419.1 - 0.029 14.3 0.0 0.061 13.2 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 ETO18419.1 - 0.059 13.4 0.0 0.13 12.2 0.0 1.5 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE TT_ORF1 PF02956.14 ETO18419.1 - 0.062 12.0 2.1 0.071 11.8 2.1 1.0 1 0 0 1 1 1 0 TT viral orf 1 MeaB PF03308.16 ETO18419.1 - 0.062 12.3 0.0 0.093 11.7 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_25 PF13481.6 ETO18419.1 - 0.088 12.4 0.0 0.17 11.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO18419.1 - 0.09 12.8 0.0 0.2 11.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Menin PF05053.13 ETO18419.1 - 0.12 10.7 3.6 0.12 10.7 3.6 1.1 1 0 0 1 1 1 0 Menin CobT PF06213.12 ETO18419.1 - 0.14 11.5 4.0 0.18 11.2 4.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CPT PF07931.12 ETO18419.1 - 0.19 11.6 0.9 0.77 9.6 0.1 2.2 2 1 1 3 3 3 0 Chloramphenicol phosphotransferase-like protein AAA_28 PF13521.6 ETO18419.1 - 0.2 11.9 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain CDC45 PF02724.14 ETO18419.1 - 0.23 9.7 6.7 0.26 9.5 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Corazonin PF17308.2 ETO18419.1 - 0.23 11.8 11.9 0.35 11.2 11.9 1.3 1 0 0 1 1 1 0 Pro-corazonin RRN3 PF05327.11 ETO18419.1 - 1.9 7.0 6.1 2.1 6.8 6.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 ETO18419.1 - 2.1 7.6 14.4 3 7.1 14.4 1.3 1 0 0 1 1 1 0 NOA36 protein Orf78 PF06024.12 ETO18419.1 - 3.1 8.1 7.4 6.3 7.2 7.4 1.7 1 0 0 1 1 1 0 Orf78 (ac78) DUF2457 PF10446.9 ETO18419.1 - 3.2 6.8 18.3 4 6.5 18.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SGT1 PF07093.11 ETO18419.1 - 3.7 5.9 8.2 4.6 5.6 8.2 1.1 1 0 0 1 1 1 0 SGT1 protein Osteopontin PF00865.18 ETO18419.1 - 5.6 6.4 18.7 8 5.9 18.7 1.2 1 0 0 1 1 1 0 Osteopontin DNA_pol_phi PF04931.13 ETO18419.1 - 9.6 4.2 9.6 11 3.9 9.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi Vfa1 PF08432.10 ETO18420.1 - 0.002 18.5 2.2 0.0034 17.7 2.2 1.4 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Lipase_3 PF01764.25 ETO18420.1 - 0.0055 16.6 0.1 0.014 15.2 0.0 1.6 2 0 0 2 2 2 1 Lipase (class 3) DUF2457 PF10446.9 ETO18420.1 - 0.031 13.5 10.6 0.041 13.0 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ETO18420.1 - 0.14 12.6 13.5 0.11 12.9 10.9 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 ETO18420.1 - 0.18 10.0 5.8 0.25 9.6 5.8 1.2 1 0 0 1 1 1 0 CDC45-like protein PI3K_1B_p101 PF10486.9 ETO18420.1 - 0.18 9.5 2.3 0.46 8.2 2.6 1.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LAT PF15234.6 ETO18420.1 - 0.23 11.2 3.4 0.34 10.6 3.4 1.2 1 0 0 1 1 1 0 Linker for activation of T-cells SDA1 PF05285.12 ETO18420.1 - 0.32 10.4 8.5 0.5 9.7 8.5 1.2 1 0 0 1 1 1 0 SDA1 DUF3245 PF11595.8 ETO18420.1 - 0.33 11.4 8.3 0.73 10.3 8.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) CENP-B_dimeris PF09026.10 ETO18420.1 - 0.36 11.2 13.4 0.84 10.1 13.4 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 ETO18420.1 - 0.44 10.5 6.5 0.71 9.9 6.5 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal NOA36 PF06524.12 ETO18420.1 - 0.49 9.7 11.8 0.76 9.0 11.8 1.2 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ETO18420.1 - 0.63 9.7 5.5 1.3 8.6 5.5 1.5 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.12 ETO18420.1 - 1 7.5 8.9 1.2 7.2 8.9 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ETO18420.1 - 1.7 6.7 12.3 2.7 6.0 12.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi Cwf_Cwc_15 PF04889.12 ETO18420.1 - 2.4 7.8 13.3 3.8 7.2 13.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2722 PF10846.8 ETO18420.1 - 3 6.7 7.3 4 6.3 7.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF4637 PF15470.6 ETO18420.1 - 3.4 7.4 5.5 5.9 6.6 5.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RRN3 PF05327.11 ETO18420.1 - 4.6 5.7 5.1 6 5.3 5.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Tom22 PF04281.13 ETO18420.1 - 5.8 6.7 7.2 14 5.5 7.2 1.6 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 DUF1624 PF07786.12 ETO18421.1 - 0.069 12.7 0.1 0.086 12.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1624) Med14 PF08638.11 ETO18422.1 - 0.0042 16.5 0.9 0.0057 16.1 0.9 1.3 1 0 0 1 1 1 1 Mediator complex subunit MED14 FNIP_M PF14637.6 ETO18422.1 - 0.023 14.7 1.7 0.037 14.0 1.7 1.3 1 0 0 1 1 1 0 Folliculin-interacting protein middle domain Peptidase_C27 PF05407.12 ETO18422.1 - 0.035 14.2 0.8 0.077 13.1 0.2 1.8 2 0 0 2 2 2 0 Rubella virus endopeptidase Ehrlichia_rpt PF09528.10 ETO18422.1 - 0.11 12.0 2.3 0.32 10.5 0.1 2.6 2 0 0 2 2 2 0 Ehrlichia tandem repeat (Ehrlichia_rpt) RNA_polI_A14 PF08203.11 ETO18422.1 - 3.4 8.4 6.6 0.91 10.3 0.6 2.7 2 1 2 4 4 4 0 Yeast RNA polymerase I subunit RPA14 ArAE_2_N PF10337.9 ETO18422.1 - 10 5.1 9.2 28 3.6 9.2 1.6 1 1 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal WD40 PF00400.32 ETO18423.1 - 1.7e-07 31.8 2.5 2.7e-07 31.2 1.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat ADIP PF11559.8 ETO18423.1 - 0.0063 16.6 19.3 0.0063 16.6 19.3 2.9 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding DUF4298 PF14131.6 ETO18423.1 - 0.012 15.5 2.6 0.012 15.5 2.6 3.7 2 2 2 4 4 4 0 Domain of unknown function (DUF4298) GldM_N PF12081.8 ETO18423.1 - 0.022 14.9 16.6 0.29 11.2 6.5 2.5 2 0 0 2 2 2 0 GldM N-terminal domain DUF4164 PF13747.6 ETO18423.1 - 0.032 14.5 0.5 0.032 14.5 0.5 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4164) HalX PF08663.10 ETO18423.1 - 0.085 13.2 0.5 3 8.2 0.2 2.5 1 1 1 2 2 2 0 HalX domain DUF812 PF05667.11 ETO18423.1 - 0.13 11.1 31.1 0.033 13.1 16.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF812) LPP PF04728.13 ETO18423.1 - 1.2 9.6 15.6 31 5.0 6.7 4.2 2 1 0 2 2 2 0 Lipoprotein leucine-zipper CENP-H PF05837.12 ETO18423.1 - 8.1 6.9 29.3 0.7 10.3 9.8 3.3 3 0 0 3 3 3 0 Centromere protein H (CENP-H) WD40 PF00400.32 ETO18424.1 - 1.6e-22 79.4 13.3 2.9e-07 31.1 1.8 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18424.1 - 1.6e-10 41.2 0.6 0.0015 18.8 0.1 3.2 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18424.1 - 4.1e-07 29.0 1.5 0.032 12.9 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO18424.1 - 0.002 17.5 2.5 0.002 17.5 2.5 2.5 2 1 1 3 3 3 1 WD40-like domain zf-TRAF PF02176.18 ETO18425.1 - 4e-05 24.2 4.2 4e-05 24.2 4.2 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger WD40 PF00400.32 ETO18426.1 - 5.1e-19 68.3 17.1 1.2e-06 29.2 0.7 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO18426.1 - 1.3e-09 37.3 3.3 0.016 13.8 1.0 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO18426.1 - 3.8e-07 30.3 0.0 0.34 11.2 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO18426.1 - 0.00035 20.0 1.4 0.014 14.8 0.3 2.2 1 1 1 2 2 2 2 WD40-like domain DUF5096 PF17019.5 ETO18426.1 - 0.36 10.6 4.1 0.31 10.8 0.6 2.0 1 1 0 2 2 2 0 Domain of unknown function (DUF5096) Ras PF00071.22 ETO18427.1 - 2.3e-05 24.0 0.0 0.00024 20.7 0.1 2.1 2 0 0 2 2 2 1 Ras family GxDLY PF14607.6 ETO18429.1 - 0.023 14.5 1.3 0.03 14.1 1.3 1.3 1 0 0 1 1 1 0 N-terminus of Esterase_SGNH_hydro-type Rad4 PF03835.15 ETO18429.1 - 0.034 13.8 8.2 0.12 12.0 8.2 1.7 1 1 0 1 1 1 0 Rad4 transglutaminase-like domain Sec62 PF03839.16 ETO18429.1 - 1.8 8.0 9.8 2.1 7.8 9.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 ETO18429.1 - 1.9 8.2 7.2 2 8.1 7.2 1.0 1 0 0 1 1 1 0 Connexin DUF3464 PF11947.8 ETO18429.1 - 2.1 8.1 8.5 2.4 7.9 8.5 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 YfhO PF09586.10 ETO18429.1 - 3.3 5.8 9.4 3.7 5.7 9.4 1.0 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF4834 PF16118.5 ETO18429.1 - 7.4 7.6 10.4 9.3 7.3 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO18429.1 - 8.3 5.1 7.8 9.4 4.9 7.8 1.0 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 ETO18430.1 - 3.1e-49 167.7 0.0 2.6e-45 154.9 0.1 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18430.1 - 4.7e-23 81.8 0.1 9e-23 80.9 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Myosin_TH1 PF06017.13 ETO18430.1 - 1.1e-05 25.3 0.3 2.5e-05 24.0 0.3 1.6 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding FTA2 PF13095.6 ETO18430.1 - 0.00031 20.4 0.8 1.7 8.2 0.1 3.3 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ETO18430.1 - 0.0014 18.0 0.1 0.047 13.0 0.0 2.4 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ETO18430.1 - 0.0016 17.8 0.4 0.0051 16.2 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.24 ETO18430.1 - 0.0042 17.8 4.4 0.013 16.2 4.4 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain APH PF01636.23 ETO18430.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO18430.1 - 0.035 13.0 0.7 0.072 12.0 0.3 1.7 1 1 0 1 1 1 0 Haspin like kinase domain GDPD PF03009.17 ETO18431.1 - 4.6e-30 105.2 0.0 6.5e-30 104.7 0.0 1.2 1 0 0 1 1 1 1 Glycerophosphoryl diester phosphodiesterase family GDPD PF03009.17 ETO18432.1 - 4.7e-12 46.2 0.1 1.3e-10 41.5 0.0 2.3 2 1 0 2 2 2 2 Glycerophosphoryl diester phosphodiesterase family MLVIN_C PF18697.1 ETO18433.1 - 0.094 12.8 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 Murine leukemia virus (MLV) integrase (IN) C-terminal domain Ank_2 PF12796.7 ETO18434.1 - 3.1e-26 91.8 5.9 2.2e-13 50.6 0.7 3.7 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO18434.1 - 7.6e-24 83.8 1.7 7.6e-10 39.1 0.0 3.9 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO18434.1 - 2e-23 79.9 0.2 0.00021 21.5 0.0 5.4 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ETO18434.1 - 1e-22 79.8 0.9 2.1e-09 37.5 0.0 4.3 2 1 2 4 4 4 4 Ankyrin repeats (many copies) Ank PF00023.30 ETO18434.1 - 4.7e-16 58.4 1.2 0.011 16.2 0.0 5.3 5 0 0 5 5 5 4 Ankyrin repeat CBM_20 PF00686.19 ETO18434.1 - 3.6e-11 42.8 0.0 9.8e-11 41.4 0.0 1.7 1 0 0 1 1 1 1 Starch binding domain DUF3447 PF11929.8 ETO18434.1 - 0.0074 16.2 1.3 0.018 15.0 0.3 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF3447) DUF1972 PF09314.11 ETO18434.1 - 0.02 14.5 0.2 2 8.0 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1972) G8 PF10162.9 ETO18437.1 - 0.16 12.0 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 G8 domain SID-1_RNA_chan PF13965.6 ETO18438.1 - 1.1 7.6 2.7 1.2 7.4 2.7 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC27 PF09507.10 ETO18438.1 - 7.2 5.9 40.6 20 4.5 40.6 1.8 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 FancD2 PF14631.6 ETO18438.1 - 7.9 3.7 13.1 11 3.2 13.1 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease TPR_12 PF13424.6 ETO18440.1 - 2.3e-32 111.1 1.6 2.8e-13 50.0 0.1 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18440.1 - 2.2e-21 74.7 17.0 4e-09 35.9 0.5 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO18440.1 - 1.8e-19 69.0 0.0 3.9e-05 23.4 0.0 4.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18440.1 - 7e-19 66.4 0.3 7.7e-05 22.4 0.0 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18440.1 - 3.3e-17 61.1 12.4 9.7e-05 22.2 0.2 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18440.1 - 6e-17 60.4 17.8 8.2e-07 28.8 0.3 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18440.1 - 5.5e-06 26.8 0.0 0.1 13.4 0.0 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO18440.1 - 1.6e-05 24.9 2.3 0.87 10.1 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18440.1 - 5.7e-05 22.7 3.6 1.2 8.9 0.0 4.4 4 1 1 5 5 5 2 TPR repeat TPR_MalT PF17874.1 ETO18440.1 - 0.00042 19.8 0.0 0.0031 16.9 0.0 2.1 1 1 1 2 2 2 1 MalT-like TPR region DUF2225 PF09986.9 ETO18440.1 - 0.00049 19.9 2.5 0.023 14.4 0.1 2.6 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 ETO18440.1 - 0.00052 20.5 1.3 27 5.7 0.0 4.5 5 1 0 5 5 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO18440.1 - 0.0014 18.8 6.1 0.0091 16.2 0.3 2.8 1 1 2 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO18440.1 - 0.0033 17.2 2.7 0.96 9.2 0.1 3.6 3 0 0 3 3 3 1 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO18440.1 - 0.0062 17.0 0.0 0.087 13.3 0.0 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat DUF627 PF04781.12 ETO18440.1 - 0.01 15.8 0.1 0.053 13.5 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF627) TPR_16 PF13432.6 ETO18440.1 - 0.013 16.1 0.0 0.14 12.9 0.0 2.6 3 0 0 3 3 2 0 Tetratricopeptide repeat PPR PF01535.20 ETO18440.1 - 0.016 15.4 0.6 4 7.9 0.0 3.8 3 0 0 3 3 3 0 PPR repeat MIT PF04212.18 ETO18440.1 - 0.14 12.2 3.3 15 5.7 0.0 3.9 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain WD40 PF00400.32 ETO18441.1 - 3.4e-60 198.6 18.2 4.2e-11 43.2 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18441.1 - 3.6e-24 84.9 2.7 0.00048 20.4 0.0 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO18441.1 - 3.4e-15 56.4 0.1 2e-07 31.1 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO18441.1 - 2.8e-09 36.4 0.7 0.23 10.4 0.0 5.9 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO18441.1 - 3.8e-08 32.4 0.7 0.24 10.0 0.0 5.0 2 2 3 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO18441.1 - 4.9e-07 29.4 0.5 0.59 9.4 0.0 3.7 1 1 2 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO18441.1 - 7e-05 21.5 1.9 0.58 8.6 0.1 3.5 1 1 4 5 5 5 3 Cytochrome D1 heme domain Germane PF10646.9 ETO18441.1 - 0.002 18.9 0.0 2.8 8.8 0.0 2.8 2 1 1 3 3 3 2 Sporulation and spore germination PD40 PF07676.12 ETO18441.1 - 0.0054 16.6 10.4 2.9 7.9 0.1 5.8 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO18441.1 - 0.0056 16.7 1.9 12 6.0 0.0 4.6 4 1 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region DPPIV_N PF00930.21 ETO18441.1 - 0.032 13.0 0.5 1.8 7.2 0.2 3.8 2 2 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region MIase PF02426.16 ETO18441.1 - 0.035 14.3 0.2 29 4.9 0.0 4.5 5 1 1 6 6 6 0 Muconolactone delta-isomerase Peptidase_S9_N PF02897.15 ETO18441.1 - 0.04 12.7 1.0 2.7 6.7 0.1 3.1 3 1 0 3 3 3 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF2963 PF11178.8 ETO18441.1 - 0.16 11.7 0.1 2.3 8.0 0.0 3.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2963) Asparaginase PF00710.20 ETO18442.1 - 9.6e-35 119.9 0.0 3.4e-34 118.1 0.0 2.0 2 1 0 2 2 2 1 Asparaginase, N-terminal DNA_pol_phi PF04931.13 ETO18442.1 - 2.4e-05 22.7 30.3 2.4e-05 22.7 30.3 2.0 2 0 0 2 2 2 1 DNA polymerase phi BUD22 PF09073.10 ETO18442.1 - 0.00013 21.4 27.1 0.00013 21.4 27.1 2.6 2 1 1 3 3 3 1 BUD22 DUF2457 PF10446.9 ETO18442.1 - 0.00099 18.4 41.7 0.00099 18.4 41.7 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO18442.1 - 0.13 10.4 39.4 0.017 13.4 33.2 2.0 2 0 0 2 2 2 0 Nop14-like family DUF4834 PF16118.5 ETO18442.1 - 0.14 13.2 0.0 0.14 13.2 0.0 4.5 4 1 1 5 5 5 0 Domain of unknown function (DUF4834) Mpp10 PF04006.12 ETO18442.1 - 0.59 8.5 36.2 0.1 11.0 27.6 2.2 2 0 0 2 2 2 0 Mpp10 protein V_ATPase_I PF01496.19 ETO18442.1 - 0.63 7.9 11.1 0.15 9.9 0.4 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ETO18442.1 - 0.83 7.9 33.7 0.031 12.6 24.6 2.2 2 0 0 2 2 2 0 CDC45-like protein Herpes_capsid PF06112.11 ETO18443.1 - 0.11 12.6 3.8 0.25 11.4 3.8 1.5 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Kelch_6 PF13964.6 ETO18446.1 - 2e-06 27.8 1.0 0.0067 16.7 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO18446.1 - 0.0013 18.6 1.7 2 8.5 0.2 4.1 4 0 0 4 4 4 2 Kelch motif HPS3_Mid PF14762.6 ETO18446.1 - 0.013 14.3 0.5 0.02 13.7 0.5 1.2 1 0 0 1 1 1 0 Hermansky-Pudlak syndrome 3, middle region Arf PF00025.21 ETO18447.1 - 1.6e-61 206.8 0.2 9.9e-37 126.1 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO18447.1 - 3e-08 33.9 0.0 0.00091 19.4 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETO18447.1 - 2.3e-07 30.4 0.0 0.012 15.1 0.1 2.3 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Ras PF00071.22 ETO18447.1 - 2.3e-05 24.0 0.0 0.18 11.4 0.1 2.2 2 0 0 2 2 2 2 Ras family MMR_HSR1 PF01926.23 ETO18447.1 - 0.00025 21.1 0.0 0.00044 20.3 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO18447.1 - 0.00073 19.0 0.0 0.046 13.1 0.0 2.2 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region G-alpha PF00503.20 ETO18447.1 - 0.0017 17.6 1.8 1.7 7.7 0.2 3.1 1 1 1 2 2 2 2 G-protein alpha subunit EHN PF06441.12 ETO18448.1 - 1.3e-19 70.6 1.0 1.9e-19 70.0 1.0 1.3 1 0 0 1 1 1 1 Epoxide hydrolase N terminus Abhydrolase_1 PF00561.20 ETO18448.1 - 0.00032 20.4 0.0 0.00044 20.0 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold EMC3_TMCO1 PF01956.16 ETO18450.1 - 0.028 14.2 0.0 0.052 13.3 0.0 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Cytochrom_B_C PF00032.17 ETO18450.1 - 0.12 12.6 4.0 0.22 11.8 4.0 1.4 1 0 0 1 1 1 0 Cytochrome b(C-terminal)/b6/petD DUF1702 PF08012.11 ETO18450.1 - 0.43 9.4 2.0 0.39 9.5 0.6 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1702) PTEN_C2 PF10409.9 ETO18451.1 - 2.5e-05 24.0 0.9 6.8e-05 22.6 0.1 2.0 1 1 0 2 2 2 1 C2 domain of PTEN tumour-suppressor protein TFIIA PF03153.13 ETO18451.1 - 0.52 10.2 49.1 0.25 11.3 25.9 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit NUDIX PF00293.28 ETO18452.1 - 0.034 14.2 0.1 0.2 11.7 0.0 2.1 1 1 0 2 2 2 0 NUDIX domain RXT2_N PF08595.11 ETO18452.1 - 2.6 8.1 12.3 1.5 8.9 8.1 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal CDC45 PF02724.14 ETO18452.1 - 3.8 5.7 12.7 6.5 4.9 12.7 1.3 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid_p PF12226.8 ETO18452.1 - 5 6.2 14.0 10 5.2 14.0 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 ETO18452.1 - 8.4 4.3 29.2 0.18 9.9 21.2 1.9 2 0 0 2 2 2 0 DNA polymerase phi RRN3 PF05327.11 ETO18452.1 - 8.6 4.8 14.9 15 3.9 14.9 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ELMO_CED12 PF04727.13 ETO18453.1 - 3e-21 76.3 1.8 3e-21 76.3 1.8 2.7 2 1 0 2 2 2 1 ELMO/CED-12 family Cwf_Cwc_15 PF04889.12 ETO18453.1 - 0.0079 16.0 4.0 0.0079 16.0 4.0 3.3 3 0 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein Nop14 PF04147.12 ETO18453.1 - 0.22 9.7 33.2 0.16 10.1 2.4 3.2 3 0 0 3 3 3 0 Nop14-like family SDA1 PF05285.12 ETO18453.1 - 1.2 8.4 42.8 0.13 11.6 4.2 3.2 3 0 0 3 3 3 0 SDA1 Na_trans_assoc PF06512.13 ETO18453.1 - 1.3 9.2 30.9 5.1 7.3 1.7 3.3 3 0 0 3 3 3 0 Sodium ion transport-associated DUF2052 PF09747.9 ETO18453.1 - 2 8.5 34.2 0.54 10.3 1.4 3.6 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Pox_Ag35 PF03286.14 ETO18453.1 - 8.9 6.0 35.0 0.34 10.7 2.3 3.6 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Ribosomal_60s PF00428.19 ETO18454.1 - 4.3e-15 56.1 2.3 6.1e-15 55.6 2.3 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein Ion_trans PF00520.31 ETO18456.1 - 2.3e-37 128.6 36.3 2.4e-27 95.7 32.3 2.8 2 1 0 2 2 2 2 Ion transport protein Nup54_57_C PF18570.1 ETO18457.1 - 0.022 14.3 0.1 0.047 13.3 0.1 1.6 1 0 0 1 1 1 0 NUP57/Nup54 C-terminal domain DUF4611 PF15387.6 ETO18458.1 - 0.017 15.4 0.7 0.034 14.3 0.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Retrotrans_gag PF03732.17 ETO18459.1 - 0.028 14.7 0.3 0.67 10.3 0.0 2.7 2 1 1 3 3 3 0 Retrotransposon gag protein SPRY PF00622.28 ETO18460.1 - 4.1e-10 39.8 0.0 5.2e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 SPRY domain G-alpha PF00503.20 ETO18461.1 - 4.5e-35 121.4 16.5 6.3e-31 107.8 6.0 2.1 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO18461.1 - 3.6e-08 33.1 1.4 5.2e-06 26.0 0.5 2.3 1 1 1 2 2 2 2 ADP-ribosylation factor family TPR_2 PF07719.17 ETO18462.1 - 0.015 15.4 0.0 0.045 13.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18462.1 - 0.054 14.3 0.9 0.31 12.0 0.0 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat HP1451_C PF18472.1 ETO18462.1 - 0.057 13.4 0.0 0.17 11.9 0.0 1.8 1 0 0 1 1 1 0 HP1451 C-terminal domain DUF4175 PF13779.6 ETO18462.1 - 0.075 10.9 10.4 0.11 10.4 10.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CCSAP PF15748.5 ETO18462.1 - 0.097 12.8 14.5 0.14 12.3 14.5 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PI3K_1B_p101 PF10486.9 ETO18462.1 - 0.12 10.1 8.2 0.15 9.8 8.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Merozoite_SPAM PF07133.11 ETO18462.1 - 0.18 11.8 38.7 0.93 9.5 38.6 1.9 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) MDM1 PF15501.6 ETO18462.1 - 0.5 9.5 17.3 0.66 9.1 17.3 1.1 1 0 0 1 1 1 0 Nuclear protein MDM1 Sporozoite_P67 PF05642.11 ETO18462.1 - 0.6 8.1 14.0 0.78 7.8 14.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SLC12 PF03522.15 ETO18462.1 - 1 8.3 8.4 1.5 7.8 8.4 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Nop53 PF07767.11 ETO18462.1 - 1.2 8.5 31.9 1.7 8.0 31.9 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF913 PF06025.12 ETO18462.1 - 2.6 6.9 7.6 3.8 6.4 7.6 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CobT PF06213.12 ETO18462.1 - 2.7 7.3 26.0 1.5 8.1 22.8 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT BSP_II PF05432.11 ETO18462.1 - 3 7.5 28.7 4.2 7.0 28.7 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RR_TM4-6 PF06459.12 ETO18462.1 - 3.8 7.2 20.0 6.1 6.6 20.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO18462.1 - 5.9 5.0 29.0 9.5 4.4 28.2 1.5 1 1 1 2 2 2 0 CDC45-like protein Presenilin PF01080.17 ETO18462.1 - 6.1 5.5 13.0 8.1 5.1 13.0 1.2 1 0 0 1 1 1 0 Presenilin Roughex PF06020.11 ETO18462.1 - 6.4 5.8 14.8 8.8 5.3 14.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein XAP5 PF04921.14 ETO18462.1 - 7.1 6.4 19.8 13 5.5 19.8 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator Neur_chan_memb PF02932.16 ETO18462.1 - 7.7 6.5 6.9 12 5.8 6.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Helicase_PWI PF18149.1 ETO18463.1 - 0.36 11.0 3.5 1.7 8.8 0.1 2.3 2 0 0 2 2 2 0 N-terminal helicase PWI domain WD40_4 PF16300.5 ETO18464.1 - 5.2e-18 64.7 0.2 9.1e-18 63.9 0.2 1.4 1 0 0 1 1 1 1 Type of WD40 repeat HAUS6_N PF14661.6 ETO18464.1 - 0.017 14.7 3.1 0.024 14.2 3.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus HALZ PF02183.18 ETO18464.1 - 0.036 14.3 0.1 0.071 13.3 0.1 1.5 1 0 0 1 1 1 0 Homeobox associated leucine zipper Pox_A_type_inc PF04508.12 ETO18464.1 - 0.055 13.3 1.3 0.13 12.1 1.3 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat GP52 PF17468.2 ETO18464.1 - 0.097 12.8 0.0 0.21 11.7 0.0 1.5 1 0 0 1 1 1 0 Phage gene product 52 Ctf8 PF09696.10 ETO18464.1 - 0.14 12.5 5.4 0.22 11.8 5.4 1.3 1 0 0 1 1 1 0 Ctf8 YabA PF06156.13 ETO18464.1 - 1.7 9.3 6.4 3.3 8.4 6.4 1.5 1 0 0 1 1 1 0 Initiation control protein YabA DUF739 PF05339.11 ETO18465.1 - 0.11 12.6 0.1 0.17 12.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF739) WD40 PF00400.32 ETO18466.1 - 3.5e-43 144.7 32.2 2.9e-06 27.9 0.3 10.1 9 1 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18466.1 - 2.3e-13 50.2 6.2 0.036 14.4 0.0 7.2 4 3 3 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18466.1 - 1e-09 37.6 9.9 0.079 11.6 0.1 5.7 3 1 2 5 5 5 5 Nucleoporin Nup120/160 Rieske_2 PF13806.6 ETO18466.1 - 0.14 12.1 0.0 5.2 7.1 0.0 3.3 3 1 1 4 4 4 0 Rieske-like [2Fe-2S] domain CDC45 PF02724.14 ETO18467.1 - 0.0045 15.4 15.9 0.0059 15.0 15.9 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF1664 PF07889.12 ETO18467.1 - 0.036 14.1 0.2 0.088 12.8 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) SLC12 PF03522.15 ETO18467.1 - 0.041 12.9 12.2 0.057 12.4 12.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PTPRCAP PF15713.5 ETO18467.1 - 0.067 13.5 12.4 0.13 12.6 12.4 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SDA1 PF05285.12 ETO18467.1 - 0.11 11.9 23.2 0.15 11.4 23.2 1.1 1 0 0 1 1 1 0 SDA1 Neur_chan_memb PF02932.16 ETO18467.1 - 0.17 11.9 2.9 0.18 11.8 2.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 ETO18467.1 - 0.19 10.1 4.1 0.2 10.1 4.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 ETO18467.1 - 0.24 10.2 15.6 0.3 9.8 14.8 1.4 1 1 0 1 1 1 0 Aluminium activated malate transporter Gti1_Pac2 PF09729.9 ETO18467.1 - 0.3 11.1 10.8 0.52 10.4 10.8 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family Nop14 PF04147.12 ETO18467.1 - 0.37 9.0 24.2 0.04 12.2 20.1 1.4 2 0 0 2 2 2 0 Nop14-like family Zip PF02535.22 ETO18467.1 - 0.38 9.9 9.3 0.63 9.2 9.3 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Mpp10 PF04006.12 ETO18467.1 - 0.43 9.0 27.5 0.0054 15.2 20.0 1.5 2 0 0 2 2 2 0 Mpp10 protein DUF2370 PF10176.9 ETO18467.1 - 0.53 9.9 4.7 0.81 9.3 4.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Presenilin PF01080.17 ETO18467.1 - 0.75 8.5 16.1 0.95 8.1 16.1 1.1 1 0 0 1 1 1 0 Presenilin Folliculin PF11704.8 ETO18467.1 - 0.79 9.6 8.4 1.5 8.6 8.3 1.7 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Tim54 PF11711.8 ETO18467.1 - 0.91 8.2 11.8 1.3 7.7 11.8 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Raftlin PF15250.6 ETO18467.1 - 1.7 7.3 10.9 2.7 6.7 10.9 1.3 1 0 0 1 1 1 0 Raftlin PNISR PF15996.5 ETO18467.1 - 3 8.1 17.5 4.4 7.5 17.5 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CLN3 PF02487.17 ETO18467.1 - 3.1 6.7 5.1 4.4 6.2 5.1 1.3 1 0 0 1 1 1 0 CLN3 protein RPOL_N PF14700.6 ETO18467.1 - 7 5.9 9.1 4.6 6.5 7.4 1.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal NPR3 PF03666.13 ETO18467.1 - 7.6 5.2 18.0 13 4.4 18.0 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Sec62 PF03839.16 ETO18467.1 - 8 5.9 10.4 13 5.2 10.4 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Dynein_AAA_lid PF17852.1 ETO18468.1 - 4.4e-20 72.1 0.0 7.2e-20 71.4 0.0 1.3 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 ETO18468.1 - 0.0029 17.6 0.0 0.0048 16.9 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_8 PF12780.7 ETO18469.1 - 2.1e-80 269.8 0.1 6.6e-80 268.2 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 ETO18469.1 - 7.8e-64 214.5 0.2 3.6e-35 121.1 0.0 3.3 3 1 1 4 4 4 2 P-loop containing dynein motor region AAA_lid_1 PF17857.1 ETO18469.1 - 1.3e-19 70.2 0.3 3.3e-19 68.9 0.3 1.7 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ETO18469.1 - 1.3e-06 28.4 0.0 0.00032 20.7 0.0 2.6 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO18469.1 - 2.3e-05 24.9 2.1 0.044 14.2 0.0 3.9 3 2 1 4 4 4 1 AAA ATPase domain AAA PF00004.29 ETO18469.1 - 0.00046 20.6 0.1 1.2 9.5 0.0 2.7 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO18469.1 - 0.00071 19.9 0.0 0.0092 16.3 0.0 2.6 3 0 0 3 3 3 1 AAA domain Rad17 PF03215.15 ETO18469.1 - 0.0082 16.1 0.2 0.035 14.0 0.1 2.1 3 0 0 3 3 3 1 Rad17 P-loop domain T2SSE PF00437.20 ETO18469.1 - 0.016 14.3 0.0 0.06 12.4 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein Sigma54_activat PF00158.26 ETO18469.1 - 0.035 13.8 0.0 0.12 12.1 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF815 PF05673.13 ETO18469.1 - 0.041 13.0 0.0 9.1 5.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 ETO18469.1 - 0.05 13.3 0.2 1.4 8.7 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain MT PF12777.7 ETO18470.1 - 2.5e-20 72.8 9.1 3e-20 72.5 9.1 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor AAA_8 PF12780.7 ETO18470.1 - 0.00014 21.3 0.7 0.00014 21.3 0.7 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 DUF948 PF06103.11 ETO18470.1 - 0.0096 16.2 5.4 0.015 15.5 3.6 2.3 1 1 1 2 2 2 1 Bacterial protein of unknown function (DUF948) PI3K_P85_iSH2 PF16454.5 ETO18470.1 - 0.019 14.6 11.3 0.036 13.7 11.3 1.6 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF4407 PF14362.6 ETO18470.1 - 0.045 13.1 3.4 0.056 12.8 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) LUC7 PF03194.15 ETO18470.1 - 0.13 11.9 10.5 0.2 11.3 10.5 1.2 1 0 0 1 1 1 0 LUC7 N_terminus Flagellin_C PF00700.21 ETO18470.1 - 0.31 11.4 5.4 18 5.8 0.4 2.6 1 1 1 2 2 2 0 Bacterial flagellin C-terminal helical region Laminin_II PF06009.12 ETO18470.1 - 0.33 11.0 8.2 0.74 9.8 7.6 1.9 1 1 0 1 1 1 0 Laminin Domain II Syntaxin_2 PF14523.6 ETO18470.1 - 0.37 11.2 7.1 1 9.7 7.1 1.9 1 1 0 1 1 1 0 Syntaxin-like protein Exonuc_VII_L PF02601.15 ETO18470.1 - 0.6 9.6 7.9 0.95 9.0 7.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CCDC53 PF10152.9 ETO18470.1 - 0.8 10.1 9.6 1.4 9.4 9.6 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex COG2 PF06148.11 ETO18470.1 - 1.4 9.1 9.9 5.3 7.1 9.2 2.3 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Seryl_tRNA_N PF02403.22 ETO18470.1 - 1.6 9.0 14.3 12 6.2 14.4 2.3 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain AAA_9 PF12781.7 ETO18471.1 - 1.1e-72 243.8 8.4 9.8e-72 240.6 7.6 2.5 2 0 0 2 2 2 1 ATP-binding dynein motor region Dynein_C PF18199.1 ETO18471.1 - 4.5e-68 229.7 0.5 4.5e-68 229.7 0.5 2.1 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETO18471.1 - 5.1e-54 182.5 0.8 1.7e-52 177.6 0.8 2.6 1 1 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ETO18471.1 - 1.6e-42 144.4 0.1 7.9e-41 138.9 0.0 3.4 2 1 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 ETO18471.1 - 9e-12 44.7 0.2 1.6e-11 43.9 0.2 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor PriC PF07445.12 ETO18471.1 - 0.66 9.9 7.1 0.13 12.2 0.5 2.8 2 0 0 2 2 2 0 Primosomal replication protein priC DHR10 PF18595.1 ETO18471.1 - 9.4 6.3 14.5 7.3 6.7 1.1 3.3 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Macoilin PF09726.9 ETO18472.1 - 0.037 12.6 13.8 0.039 12.5 13.8 1.1 1 0 0 1 1 1 0 Macoilin family LKAAEAR PF15478.6 ETO18472.1 - 0.07 13.4 0.1 0.07 13.4 0.1 2.5 3 0 0 3 3 3 0 Family of unknown function with LKAAEAR motif SLC12 PF03522.15 ETO18472.1 - 0.66 8.9 12.7 0.94 8.4 12.7 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ETO18472.1 - 1.4 7.6 13.0 1.9 7.2 13.0 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO18472.1 - 2.6 6.3 12.8 3.7 5.8 12.8 1.3 1 0 0 1 1 1 0 Menin PNISR PF15996.5 ETO18472.1 - 3.4 7.9 18.3 5.5 7.2 18.3 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SURF2 PF05477.11 ETO18472.1 - 5.8 6.5 19.6 10 5.8 19.6 1.3 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Sybindin PF04099.12 ETO18473.1 - 3.5e-21 75.6 1.7 5.1e-21 75.1 1.7 1.3 1 0 0 1 1 1 1 Sybindin-like family Sedlin_N PF04628.13 ETO18473.1 - 6.3e-05 23.1 2.4 0.00011 22.3 2.4 1.5 1 0 0 1 1 1 1 Sedlin, N-terminal conserved region WD40 PF00400.32 ETO18474.1 - 5.7e-13 49.1 8.9 0.00016 22.4 0.2 5.0 4 1 0 4 4 4 4 WD domain, G-beta repeat Ribosomal_S3Ae PF01015.18 ETO18475.1 - 1.6e-35 122.6 1.0 3.8e-35 121.3 1.0 1.5 1 1 0 1 1 1 1 Ribosomal S3Ae family DUF5345 PF17280.2 ETO18477.1 - 0.078 13.0 0.9 0.18 11.8 0.9 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Mito_fiss_reg PF05308.11 ETO18478.1 - 0.27 11.3 4.0 0.56 10.2 4.0 1.4 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 ETO18478.1 - 0.63 10.1 6.6 2.4 8.2 6.6 2.0 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 CAP_N PF01213.19 ETO18478.1 - 2.5 7.5 9.9 3.9 6.9 9.9 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal OB_NTP_bind PF07717.16 ETO18479.1 - 6.3e-15 55.3 0.1 9.7e-15 54.7 0.1 1.3 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold GST_N_3 PF13417.6 ETO18480.1 - 1.6e-15 57.3 0.1 5e-10 39.6 0.1 2.4 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETO18480.1 - 3.3e-08 33.7 0.0 2.8e-05 24.3 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ETO18480.1 - 0.0071 16.7 0.2 0.042 14.2 0.1 2.3 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain Glutaredoxin PF00462.24 ETO18480.1 - 0.044 14.0 0.0 0.19 12.0 0.0 2.1 2 0 0 2 2 2 0 Glutaredoxin DNA_pol3_delta2 PF13177.6 ETO18481.1 - 0.019 14.7 0.8 0.23 11.2 0.1 2.3 1 1 1 2 2 2 0 DNA polymerase III, delta subunit DUF1610 PF07754.11 ETO18481.1 - 0.025 14.5 0.3 0.052 13.5 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) DUF2752 PF10825.8 ETO18481.1 - 0.45 10.6 2.1 0.83 9.8 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2752) Diedel PF13164.6 ETO18482.1 - 0.0015 18.9 15.9 0.0015 18.9 15.9 2.1 2 0 0 2 2 2 1 Diedel Guanylate_cyc PF00211.20 ETO18483.1 - 3.8e-09 36.4 0.1 4.9e-09 36.1 0.1 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain RIH_assoc PF08454.11 ETO18483.1 - 0.076 12.9 2.8 0.096 12.5 2.8 1.4 1 1 0 1 1 1 0 RyR and IP3R Homology associated DUF5523 PF17661.1 ETO18484.1 - 0.026 14.2 5.6 0.041 13.6 5.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5523) NOA36 PF06524.12 ETO18484.1 - 0.54 9.5 9.0 1 8.7 9.0 1.4 1 0 0 1 1 1 0 NOA36 protein SDA1 PF05285.12 ETO18484.1 - 0.94 8.8 13.0 7.6 5.8 0.2 2.2 2 0 0 2 2 2 0 SDA1 PrsW-protease PF13367.6 ETO18485.1 - 3.8e-07 29.7 9.9 8.5e-07 28.6 9.9 1.7 1 1 0 1 1 1 1 PrsW family intramembrane metalloprotease Mucin PF01456.17 ETO18485.1 - 0.09 12.8 11.6 0.18 11.8 11.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein PDZ PF00595.24 ETO18486.1 - 0.0059 16.9 0.2 0.018 15.4 0.2 1.8 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO18486.1 - 0.044 13.6 0.1 1.3 8.9 0.1 2.7 3 0 0 3 3 3 0 PDZ domain WD40 PF00400.32 ETO18488.1 - 1.4e-27 95.4 6.6 1.2e-08 35.4 0.0 4.1 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18488.1 - 2.6e-12 46.9 1.0 0.011 16.0 0.0 4.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO18488.1 - 7.5e-07 28.8 2.0 0.001 18.5 0.0 2.2 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETO18488.1 - 2.5e-05 23.4 0.1 0.013 14.5 0.1 2.8 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO18488.1 - 0.0011 17.8 0.6 0.98 8.0 0.0 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO18488.1 - 0.005 15.4 0.6 0.3 9.6 0.1 2.0 1 1 1 2 2 2 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO18488.1 - 0.013 14.4 0.5 5.9 5.7 0.0 3.0 1 1 2 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 ETO18488.1 - 0.016 14.0 0.7 0.076 11.7 0.5 2.1 1 1 1 2 2 2 0 Nup133 N terminal like DUF4988 PF16378.5 ETO18488.1 - 0.028 14.1 0.5 0.26 10.9 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function WD40 PF00400.32 ETO18489.1 - 2.1e-38 129.6 29.3 1.5e-07 31.9 0.4 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18489.1 - 4.8e-10 39.6 0.8 0.037 14.3 0.0 4.9 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18489.1 - 2.5e-07 29.7 6.1 0.018 13.7 0.9 4.9 3 2 1 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO18489.1 - 0.00086 20.0 3.2 0.00086 20.0 3.2 3.2 3 0 0 3 3 3 1 TRAF-type zinc finger Exonuc_VII_L PF02601.15 ETO18489.1 - 2.7 7.5 9.3 4.4 6.8 9.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit TPR_12 PF13424.6 ETO18490.1 - 2.4e-134 437.9 13.5 9.8e-22 77.0 0.1 7.8 3 2 5 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO18490.1 - 2.7e-107 348.2 0.0 2.2e-11 43.3 0.0 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18490.1 - 3.7e-76 245.7 13.0 7.9e-09 34.9 0.0 10.4 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18490.1 - 2.6e-70 229.6 64.5 2.2e-10 39.9 1.1 11.2 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18490.1 - 7.6e-58 188.0 67.4 6.7e-09 35.3 0.9 10.6 11 0 0 11 11 10 10 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18490.1 - 3.1e-55 179.9 41.8 1.1e-07 31.4 0.3 10.9 11 0 0 11 11 11 10 Tetratricopeptide repeat TPR_17 PF13431.6 ETO18490.1 - 8.2e-43 141.7 16.1 0.00052 20.2 0.0 10.8 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 ETO18490.1 - 9.1e-36 122.2 0.0 0.00034 21.2 0.0 10.0 9 1 1 10 10 10 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18490.1 - 3.1e-19 68.0 0.0 0.21 12.5 0.0 9.2 8 1 1 9 9 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18490.1 - 3.3e-17 61.9 14.7 0.72 10.6 0.1 10.5 10 0 0 10 10 10 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO18490.1 - 2.3e-16 60.1 0.0 0.00031 20.3 0.0 3.7 1 1 3 4 4 4 4 MalT-like TPR region TPR_11 PF13414.6 ETO18490.1 - 3e-16 58.8 75.7 0.00015 21.4 4.3 15.7 7 3 6 13 13 13 7 TPR repeat DUF5113 PF17140.4 ETO18490.1 - 3.9e-15 56.0 26.5 0.29 10.9 0.2 9.3 8 1 1 9 9 9 6 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO18490.1 - 3.3e-13 49.3 49.7 0.0002 21.2 2.0 10.5 10 0 0 10 10 10 4 Tetratricopeptide repeat SNAP PF14938.6 ETO18490.1 - 3.3e-11 43.2 16.2 0.00049 19.6 2.4 5.7 2 1 3 6 6 6 5 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO18490.1 - 2.8e-10 40.1 47.5 0.038 14.0 0.3 9.3 9 0 0 9 9 9 5 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO18490.1 - 4.2e-10 40.0 6.0 0.095 13.2 0.0 6.6 2 1 8 10 10 10 3 Tetratricopeptide repeat PPR PF01535.20 ETO18490.1 - 3.5e-09 36.3 28.2 0.15 12.4 0.1 9.5 11 0 0 11 11 10 4 PPR repeat DUF4810 PF16068.5 ETO18490.1 - 4.7e-08 33.5 13.1 12 6.6 0.8 8.9 6 2 2 9 9 9 0 Domain of unknown function (DUF4810) ANAPC3 PF12895.7 ETO18490.1 - 2.5e-06 27.6 27.4 0.22 11.7 1.1 7.9 4 1 4 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 UBA_6 PF18039.1 ETO18490.1 - 2.6e-06 27.2 0.0 9.1 6.3 0.0 6.7 7 0 0 7 7 7 0 UBA-like domain RPN7 PF10602.9 ETO18490.1 - 8.5e-05 22.3 22.0 0.17 11.6 0.1 6.7 1 1 6 7 7 7 2 26S proteasome subunit RPN7 HisG PF01634.18 ETO18490.1 - 0.00019 21.5 0.7 20 5.1 0.0 5.3 1 1 5 7 7 7 0 ATP phosphoribosyltransferase OrfA PF17495.2 ETO18490.1 - 0.00071 19.7 0.0 66 3.7 0.0 6.3 2 2 6 8 8 8 0 Vpr-like OrfA SPO22 PF08631.10 ETO18490.1 - 0.0012 18.4 6.6 1.1 8.6 0.7 4.1 2 2 1 4 4 4 2 Meiosis protein SPO22/ZIP4 like BTAD PF03704.17 ETO18490.1 - 0.0096 16.4 0.0 6.8 7.1 0.0 3.9 4 0 0 4 4 4 0 Bacterial transcriptional activator domain PHM7_ext PF12621.8 ETO18490.1 - 0.012 15.7 0.3 4.1 7.6 0.0 3.0 2 1 1 3 3 3 0 Extracellular tail, of 10TM putative phosphate transporter DUF627 PF04781.12 ETO18490.1 - 0.013 15.5 8.9 5.4 7.1 1.2 5.9 5 2 0 5 5 5 0 Protein of unknown function (DUF627) G-7-MTase PF12803.7 ETO18490.1 - 0.014 14.6 0.0 3.6 6.7 0.0 3.2 3 0 0 3 3 3 0 mRNA (guanine-7-)methyltransferase (G-7-MTase) TPR_9 PF13371.6 ETO18490.1 - 0.016 15.4 0.0 40 4.4 0.0 4.1 3 2 4 7 7 6 0 Tetratricopeptide repeat FATC PF02260.20 ETO18490.1 - 0.02 14.7 8.0 1.1e+02 2.8 0.2 6.7 7 0 0 7 7 7 0 FATC domain TPR_21 PF09976.9 ETO18490.1 - 0.067 12.9 12.5 0.33 10.6 0.5 5.0 3 2 2 5 5 5 0 Tetratricopeptide repeat-like domain PPR_2 PF13041.6 ETO18490.1 - 0.1 12.8 14.0 34 4.7 0.1 6.8 7 0 0 7 7 6 0 PPR repeat family HTH_Bact PF18768.1 ETO18490.1 - 0.38 10.4 22.8 35 4.1 0.2 9.3 8 4 3 11 11 11 0 Helix-turn-helix bacterial domain SPAN-X PF07458.12 ETO18490.1 - 0.41 11.1 6.4 54 4.3 0.1 5.6 7 1 1 8 8 4 0 Sperm protein associated with nucleus, mapped to X chromosome Clathrin PF00637.20 ETO18490.1 - 1.2 9.0 14.2 7 6.5 0.1 5.7 2 2 1 4 4 4 0 Region in Clathrin and VPS TetR_C_19 PF17924.1 ETO18490.1 - 1.3 9.6 4.3 2.6e+02 2.2 0.0 4.6 4 0 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Mad3_BUB1_I PF08311.12 ETO18490.1 - 7.6 6.5 10.5 3.4 7.7 0.0 4.8 5 0 0 5 5 5 0 Mad3/BUB1 homology region 1 cNMP_binding PF00027.29 ETO18492.1 - 1.6e-12 47.3 0.1 6.9e-11 42.1 0.0 2.3 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain PLD_C PF12357.8 ETO18492.1 - 0.0077 16.1 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 Phospholipase D C terminal DUF4011 PF13195.6 ETO18494.1 - 4e-41 140.6 2.4 5.4e-41 140.2 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4011) UvrD-helicase PF00580.21 ETO18494.1 - 3.2e-06 26.9 1.3 3.2e-06 26.9 1.3 2.6 1 1 1 2 2 2 1 UvrD/REP helicase N-terminal domain AAA_19 PF13245.6 ETO18494.1 - 3.4e-06 27.4 0.1 8.8e-06 26.1 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO18494.1 - 4.2e-06 26.6 0.0 8e-06 25.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETO18494.1 - 5.9e-06 26.2 0.2 1.6e-05 24.8 0.2 1.8 1 0 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ETO18494.1 - 0.00062 19.1 0.1 0.0013 18.1 0.1 1.5 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) IstB_IS21 PF01695.17 ETO18494.1 - 0.0025 17.6 0.0 0.0063 16.3 0.0 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein ResIII PF04851.15 ETO18494.1 - 0.0047 17.0 1.1 0.012 15.7 0.2 2.2 2 0 0 2 2 1 1 Type III restriction enzyme, res subunit AAA_24 PF13479.6 ETO18494.1 - 0.0092 15.7 0.1 0.044 13.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain FtsK_SpoIIIE PF01580.18 ETO18494.1 - 0.013 14.9 0.1 0.039 13.3 0.0 1.7 2 0 0 2 2 2 0 FtsK/SpoIIIE family AAA_18 PF13238.6 ETO18494.1 - 0.021 15.3 0.0 0.12 12.9 0.0 2.4 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO18494.1 - 0.022 15.2 0.0 0.073 13.5 0.0 1.9 1 0 0 1 1 1 0 AAA ATPase domain Adeno_IVa2 PF02456.15 ETO18494.1 - 0.022 13.5 0.0 0.044 12.6 0.0 1.4 1 0 0 1 1 1 0 Adenovirus IVa2 protein Helicase_RecD PF05127.14 ETO18494.1 - 0.043 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 Helicase AAA_7 PF12775.7 ETO18494.1 - 0.054 13.0 0.5 0.27 10.7 0.0 2.2 1 1 0 2 2 2 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ETO18494.1 - 0.055 13.9 0.0 0.26 11.7 0.0 2.2 1 1 0 1 1 1 0 RNA helicase AAA_33 PF13671.6 ETO18494.1 - 0.063 13.4 0.0 0.2 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ETO18494.1 - 0.069 12.7 0.4 0.26 10.8 0.0 2.1 3 0 0 3 3 3 0 AAA domain ATPase PF06745.13 ETO18494.1 - 0.096 12.0 0.0 0.29 10.4 0.0 1.8 1 0 0 1 1 1 0 KaiC DEAD PF00270.29 ETO18494.1 - 0.12 12.2 0.0 0.26 11.0 0.0 1.7 1 0 0 1 1 1 0 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO18494.1 - 0.15 12.3 0.1 0.63 10.3 0.1 2.1 1 1 0 1 1 1 0 AAA domain TraT PF05818.12 ETO18495.1 - 9e-66 221.6 3.8 1e-65 221.4 3.8 1.0 1 0 0 1 1 1 1 Enterobacterial TraT complement resistance protein TFIIA PF03153.13 ETO18496.1 - 0.0077 16.3 24.3 0.01 15.9 24.3 1.3 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit CagX PF03524.15 ETO18496.1 - 0.012 15.3 1.3 0.02 14.6 1.3 1.3 1 0 0 1 1 1 0 Conjugal transfer protein EPL1 PF10513.9 ETO18496.1 - 0.016 15.6 7.7 0.016 15.6 7.7 2.0 2 0 0 2 2 2 0 Enhancer of polycomb-like DDHD PF02862.17 ETO18496.1 - 0.027 14.6 7.5 0.036 14.2 7.5 1.2 1 0 0 1 1 1 0 DDHD domain SOG2 PF10428.9 ETO18496.1 - 0.23 10.6 15.1 0.26 10.5 15.1 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein DUF4407 PF14362.6 ETO18496.1 - 1.1 8.5 4.4 1.4 8.2 4.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NicO PF03824.16 ETO18496.1 - 1.2 8.4 9.0 1.6 8.0 9.0 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein DUF4551 PF15087.6 ETO18496.1 - 1.6 7.4 14.5 1.9 7.3 14.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) TCP PF03634.13 ETO18496.1 - 2.7 8.6 16.3 4.5 7.8 16.3 1.3 1 0 0 1 1 1 0 TCP family transcription factor CLN3 PF02487.17 ETO18496.1 - 8.7 5.3 8.2 13 4.6 8.2 1.2 1 0 0 1 1 1 0 CLN3 protein SAM_1 PF00536.30 ETO18497.1 - 8.4e-08 32.6 0.1 1.4e-07 31.9 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO18497.1 - 1.4e-06 28.3 0.0 3.7e-06 26.9 0.0 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) B56 PF01603.20 ETO18498.1 - 2.2e-47 162.0 3.2 2.1e-46 158.8 0.1 2.0 1 1 1 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) Syntaphilin PF15290.6 ETO18499.1 - 0.0045 16.7 2.3 0.0071 16.0 2.3 1.2 1 0 0 1 1 1 1 Golgi-localised syntaxin-1-binding clamp YqfQ PF14181.6 ETO18500.1 - 0.65 10.2 3.7 1.5 9.0 3.7 1.6 1 0 0 1 1 1 0 YqfQ-like protein P120R PF08062.11 ETO18500.1 - 8.9 6.8 0.0 8.9 6.8 0.0 3.2 4 0 0 4 4 4 0 P120R (NUC006) repeat DUF913 PF06025.12 ETO18501.1 - 0.015 14.3 5.0 0.17 10.8 1.9 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO18501.1 - 0.021 13.6 12.6 0.2 10.4 12.8 2.2 2 0 0 2 2 2 0 Presenilin DUF4746 PF15928.5 ETO18501.1 - 1.9 7.8 7.7 4.3 6.7 7.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Spt20 PF12090.8 ETO18501.1 - 2 8.0 26.0 0.054 13.1 18.8 1.9 2 0 0 2 2 2 0 Spt20 family CDC45 PF02724.14 ETO18502.1 - 0.0058 15.0 13.0 0.15 10.3 3.4 2.3 2 0 0 2 2 2 2 CDC45-like protein Connexin PF00029.19 ETO18502.1 - 0.05 13.4 5.7 0.19 11.5 4.4 2.4 3 0 0 3 3 3 0 Connexin EMC3_TMCO1 PF01956.16 ETO18502.1 - 0.077 12.7 1.4 0.16 11.7 1.4 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like CPSF100_C PF13299.6 ETO18502.1 - 2.4 8.3 12.9 0.27 11.4 2.2 3.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal MAS20 PF02064.15 ETO18502.1 - 6.9 6.8 10.9 13 5.9 8.0 2.5 2 0 0 2 2 2 0 MAS20 protein import receptor RNA_pol_Rpc4 PF05132.14 ETO18502.1 - 7.4 7.0 9.9 4.8 7.6 4.0 2.9 3 0 0 3 3 3 0 RNA polymerase III RPC4 RXT2_N PF08595.11 ETO18502.1 - 7.9 6.5 21.7 0.3 11.1 1.7 3.0 3 0 0 3 3 3 0 RXT2-like, N-terminal YL1 PF05764.13 ETO18502.1 - 7.9 6.5 25.6 2.5 8.2 0.2 3.1 2 1 0 2 2 2 0 YL1 nuclear protein DUF3464 PF11947.8 ETO18502.1 - 9.5 6.0 10.7 29 4.4 7.6 2.5 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Shisa PF13908.6 ETO18503.1 - 0.015 15.6 1.0 0.015 15.6 1.0 2.3 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Mating_N PF12731.7 ETO18504.1 - 0.1 12.7 4.6 0.2 11.8 0.3 3.1 1 1 1 3 3 3 0 Mating-type protein beta 1 T2SSF PF00482.23 ETO18504.1 - 1.1 9.2 7.2 0.24 11.3 1.0 2.8 2 1 0 3 3 3 0 Type II secretion system (T2SS), protein F RNase_J_C PF17770.1 ETO18504.1 - 1.4 10.0 6.7 2.7 9.1 1.7 3.1 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain DUF4806 PF16064.5 ETO18504.1 - 1.9 8.8 9.9 0.85 10.0 0.7 4.3 3 2 1 4 4 4 0 Domain of unknown function (DUF4806) Baculo_PEP_C PF04513.12 ETO18504.1 - 2 8.5 13.1 2.4 8.2 4.1 2.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus FapA PF03961.13 ETO18504.1 - 2.1 6.9 22.5 0.76 8.3 5.9 2.5 1 1 1 2 2 2 0 Flagellar Assembly Protein A ApoO PF09769.9 ETO18504.1 - 3.3 7.7 5.3 7.8 6.5 0.7 2.7 2 0 0 2 2 2 0 Apolipoprotein O Laminin_II PF06009.12 ETO18504.1 - 4.5 7.3 14.5 0.19 11.7 4.1 2.8 1 1 1 2 2 2 0 Laminin Domain II V-SNARE PF05008.15 ETO18504.1 - 6.7 7.2 22.4 2.1 8.8 10.1 3.0 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DEP PF00610.21 ETO18506.1 - 1.6e-11 44.1 0.0 3.6e-11 42.9 0.0 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_6 PF13405.6 ETO18506.1 - 1.8e-06 27.4 0.2 0.028 14.4 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO18506.1 - 2.2e-05 24.8 0.3 0.0011 19.4 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO18506.1 - 2.5e-05 23.5 0.9 0.14 11.8 0.1 2.5 2 0 0 2 2 2 2 EF hand DUF4523 PF15023.6 ETO18506.1 - 0.096 12.5 0.1 0.18 11.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4523) EF-hand_9 PF14658.6 ETO18506.1 - 0.17 12.2 0.3 50 4.3 0.1 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_1 PF00036.32 ETO18507.1 - 0.13 11.8 0.1 0.53 10.0 0.0 2.1 2 0 0 2 2 2 0 EF hand DUF4713 PF15831.5 ETO18507.1 - 0.3 11.6 7.7 0.89 10.1 3.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4713) DUF4191 PF13829.6 ETO18507.1 - 7.1 5.9 10.9 0.58 9.5 4.6 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4191) WD40 PF00400.32 ETO18508.1 - 4e-05 24.3 1.1 0.0005 20.8 0.7 2.8 3 1 0 3 3 3 1 WD domain, G-beta repeat Laminin_G_3 PF13385.6 ETO18509.1 - 6.7e-05 23.1 0.0 9.3e-05 22.6 0.0 1.3 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily BCIP PF13862.6 ETO18510.1 - 3.4e-19 69.4 6.7 2e-13 50.6 2.2 2.6 2 1 0 2 2 2 2 p21-C-terminal region-binding protein 7TMR-DISM_7TM PF07695.11 ETO18510.1 - 7.4 6.4 22.5 0.6 10.0 8.3 2.1 2 0 0 2 2 2 0 7TM diverse intracellular signalling DEAD PF00270.29 ETO18511.1 - 5.8e-19 68.5 0.0 1.1e-18 67.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO18511.1 - 0.0004 20.4 0.0 0.00097 19.2 0.0 1.8 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit T2SSE PF00437.20 ETO18511.1 - 0.016 14.2 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 ETO18511.1 - 0.061 13.6 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ETO18511.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.7 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea NOT2_3_5 PF04153.18 ETO18512.1 - 7.8e-24 84.2 23.5 7.8e-20 71.3 7.1 3.9 3 1 0 4 4 4 2 NOT2 / NOT3 / NOT5 family DUF2417 PF10329.9 ETO18513.1 - 0.00014 21.4 0.7 0.00016 21.2 0.7 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Ost5 PF05251.12 ETO18513.1 - 0.041 14.2 1.7 0.36 11.1 0.6 2.3 2 0 0 2 2 2 0 Oligosaccharyltransferase subunit 5 Pkinase PF00069.25 ETO18516.1 - 2.2e-27 96.1 0.0 2.3e-27 96.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18516.1 - 9.3e-06 25.1 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO18516.1 - 0.00023 21.2 0.0 0.0003 20.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ETO18516.1 - 0.099 12.2 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Pkinase PF00069.25 ETO18517.1 - 1.8e-15 57.0 0.0 2.8e-15 56.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18517.1 - 8.3e-06 25.3 0.0 1.2e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Mitofilin PF09731.9 ETO18519.1 - 3 6.6 27.3 3.4 6.4 27.3 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Trypan_PARP PF05887.11 ETO18519.1 - 4.7 7.2 16.8 7.3 6.6 16.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) SOBP PF15279.6 ETO18519.1 - 9.2 6.8 13.8 11 6.5 13.8 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DEAD PF00270.29 ETO18520.1 - 4.6e-09 36.3 0.0 1e-08 35.1 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase HATPase_c_2 PF13581.6 ETO18521.1 - 4.1e-06 26.8 0.0 8e-06 25.8 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-like ATPase domain HATPase_c PF02518.26 ETO18521.1 - 1.7e-05 25.3 0.1 3e-05 24.5 0.1 1.5 1 1 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HTH_IclR PF09339.10 ETO18521.1 - 9.1e-05 22.2 0.0 0.00016 21.4 0.0 1.3 1 0 0 1 1 1 1 IclR helix-turn-helix domain GntR PF00392.21 ETO18521.1 - 0.00019 21.0 0.0 0.00038 20.1 0.0 1.5 1 0 0 1 1 1 1 Bacterial regulatory proteins, gntR family TrmB PF01978.19 ETO18521.1 - 0.00028 20.7 0.0 0.00069 19.4 0.0 1.6 2 0 0 2 2 2 1 Sugar-specific transcriptional regulator TrmB HTH_24 PF13412.6 ETO18521.1 - 0.0029 17.1 0.0 0.088 12.4 0.0 2.5 2 0 0 2 2 2 1 Winged helix-turn-helix DNA-binding MarR PF01047.22 ETO18521.1 - 0.0036 17.2 0.0 0.0075 16.2 0.0 1.5 1 0 0 1 1 1 1 MarR family HATPase_c_3 PF13589.6 ETO18521.1 - 0.005 16.7 0.0 0.0082 16.0 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HTH_DeoR PF08220.12 ETO18521.1 - 0.0068 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 DeoR-like helix-turn-helix domain HTH_Crp_2 PF13545.6 ETO18521.1 - 0.0079 16.1 0.0 0.016 15.2 0.0 1.5 1 0 0 1 1 1 1 Crp-like helix-turn-helix domain Rrf2 PF02082.20 ETO18521.1 - 0.031 14.6 0.0 0.065 13.6 0.0 1.6 1 0 0 1 1 1 0 Transcriptional regulator MarR_2 PF12802.7 ETO18521.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 MarR family Ank_2 PF12796.7 ETO18522.1 - 5.5e-09 36.5 0.0 0.00045 20.7 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO18522.1 - 1.6e-07 31.4 0.0 0.098 13.1 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETO18522.1 - 2.5e-05 24.3 0.0 8 7.4 0.0 4.0 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ETO18522.1 - 5.1e-05 23.7 0.0 11 6.7 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeats (many copies) XK-related PF09815.9 ETO18522.1 - 0.044 12.8 0.2 0.064 12.3 0.2 1.2 1 0 0 1 1 1 0 XK-related protein Ank_5 PF13857.6 ETO18522.1 - 0.13 12.6 0.2 28 5.2 0.1 3.3 2 2 1 3 3 3 0 Ankyrin repeats (many copies) Med6 PF04934.14 ETO18523.1 - 1.3e-29 102.7 0.5 2.6e-29 101.7 0.5 1.6 1 0 0 1 1 1 1 MED6 mediator sub complex component Tub_N PF16322.5 ETO18523.1 - 0.084 13.3 0.3 0.084 13.3 0.3 2.6 2 1 0 2 2 2 0 Tubby N-terminal ELL PF10390.9 ETO18524.1 - 0.00037 20.1 0.0 0.00047 19.7 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase II elongation factor ELL PBP1_TM PF14812.6 ETO18525.1 - 0.16 12.3 6.5 0.29 11.5 6.5 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MAS20 PF02064.15 ETO18526.1 - 0.15 12.1 12.6 0.36 10.9 12.6 1.5 1 0 0 1 1 1 0 MAS20 protein import receptor Connexin PF00029.19 ETO18526.1 - 0.16 11.7 1.0 1 9.1 0.6 2.2 2 0 0 2 2 2 0 Connexin DUF4820 PF16091.5 ETO18526.1 - 0.32 10.3 6.0 0.039 13.3 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Ferlin_C PF16165.5 ETO18526.1 - 4.8 7.1 9.6 14 5.6 6.1 2.5 2 0 0 2 2 2 0 Ferlin C-terminus Ion_trans PF00520.31 ETO18528.1 - 1.2e-18 67.3 11.3 2.3e-09 36.8 1.4 2.1 2 0 0 2 2 2 2 Ion transport protein SpecificRecomb PF10136.9 ETO18528.1 - 0.078 11.3 0.4 0.12 10.7 0.4 1.2 1 0 0 1 1 1 0 Site-specific recombinase Baculo_11_kDa PF06143.11 ETO18528.1 - 2.3 7.9 6.7 4.2 7.0 0.7 2.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family Ion_trans PF00520.31 ETO18529.1 - 2.4e-07 30.3 6.9 2.4e-07 30.3 6.9 1.9 2 0 0 2 2 2 1 Ion transport protein DUF2663 PF10864.8 ETO18529.1 - 0.22 11.9 0.2 0.22 11.9 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2663) Nexin_C PF08628.12 ETO18531.1 - 0.015 15.9 5.9 0.33 11.5 0.2 2.9 2 1 0 2 2 2 0 Sorting nexin C terminal YonK PF09642.10 ETO18531.1 - 0.074 13.2 4.7 2.1 8.5 0.3 2.7 2 0 0 2 2 2 0 YonK protein ApoO PF09769.9 ETO18531.1 - 2.5 8.1 11.5 3.8 7.5 2.8 3.8 3 1 0 4 4 4 0 Apolipoprotein O PKI PF02827.16 ETO18531.1 - 4.5 7.6 8.0 11 6.3 0.1 3.1 2 1 0 2 2 2 0 cAMP-dependent protein kinase inhibitor TMF_TATA_bd PF12325.8 ETO18531.1 - 6.6 7.0 54.2 0.38 11.0 14.8 4.1 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding YabA PF06156.13 ETO18531.1 - 6.7 7.4 47.6 0.23 12.1 3.3 4.9 1 1 3 4 4 4 0 Initiation control protein YabA SLED PF12140.8 ETO18532.1 - 0.067 13.7 1.0 0.12 12.9 1.0 1.4 1 0 0 1 1 1 0 SLED domain AAA PF00004.29 ETO18534.1 - 5.7e-05 23.5 0.0 0.00024 21.5 0.0 2.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO18534.1 - 0.00016 22.0 0.1 0.0024 18.1 0.0 3.1 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO18534.1 - 0.00087 19.3 0.0 0.006 16.6 0.0 2.5 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO18534.1 - 0.0031 17.1 0.0 0.01 15.4 0.0 1.9 1 0 0 1 1 1 1 P-loop containing dynein motor region MLD PF11647.8 ETO18534.1 - 0.0035 17.6 4.8 0.25 11.6 0.2 4.0 4 0 0 4 4 4 1 Membrane Localization Domain ABC_tran PF00005.27 ETO18534.1 - 0.0078 16.7 3.1 0.014 15.9 0.0 3.0 2 1 0 2 2 2 1 ABC transporter AAA_14 PF13173.6 ETO18534.1 - 0.011 15.7 6.1 0.03 14.3 0.0 3.7 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 ETO18534.1 - 0.012 15.6 0.0 0.035 14.0 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase MCM PF00493.23 ETO18534.1 - 0.054 12.6 0.0 0.16 11.0 0.0 1.8 1 0 0 1 1 1 0 MCM P-loop domain PduV-EutP PF10662.9 ETO18534.1 - 0.058 13.1 0.1 0.27 11.0 0.1 2.2 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NACHT PF05729.12 ETO18534.1 - 0.07 13.0 0.3 0.42 10.5 0.0 2.6 2 0 0 2 2 2 0 NACHT domain AAA_16 PF13191.6 ETO18534.1 - 0.079 13.3 0.0 0.29 11.5 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ETO18534.1 - 0.1 12.6 0.0 0.42 10.6 0.0 2.1 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 ETO18534.1 - 0.23 11.6 1.4 2.4 8.3 0.0 3.3 3 0 0 3 3 3 0 Sigma-54 interaction domain MIEAP PF16026.5 ETO18536.1 - 5.8e-14 52.8 2.1 5.8e-14 52.8 2.1 1.9 2 0 0 2 2 2 1 Mitochondria-eating protein RicinB_lectin_2 PF14200.6 ETO18537.1 - 0.012 16.3 0.0 0.4 11.4 0.0 2.6 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like GWT1 PF06423.12 ETO18537.1 - 0.09 12.9 2.4 0.24 11.5 2.4 1.7 1 0 0 1 1 1 0 GWT1 ADD_ATRX PF17981.1 ETO18538.1 - 0.086 12.7 1.4 1.2 9.0 0.5 2.3 2 0 0 2 2 2 0 Cysteine Rich ADD domain FixQ PF05545.11 ETO18538.1 - 0.14 12.1 0.9 0.25 11.4 0.9 1.4 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ LIM PF00412.22 ETO18538.1 - 0.39 11.0 5.0 1.2 9.4 5.0 1.7 1 1 0 1 1 1 0 LIM domain zf-C3HC4_3 PF13920.6 ETO18538.1 - 0.63 9.9 5.5 6.9 6.6 0.7 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Gram_pos_anchor PF00746.21 ETO18538.1 - 1.7 8.6 6.8 3 7.9 6.8 1.4 1 0 0 1 1 1 0 LPXTG cell wall anchor motif DZR PF12773.7 ETO18539.1 - 0.00078 19.4 0.9 0.0018 18.3 0.9 1.5 1 0 0 1 1 1 1 Double zinc ribbon DUF4205 PF13898.6 ETO18539.1 - 0.01 14.8 0.8 0.023 13.6 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4205) zf-UBR PF02207.20 ETO18539.1 - 0.02 15.0 0.5 0.045 13.9 0.5 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) DUF2616 PF11077.8 ETO18539.1 - 0.066 12.9 5.7 0.14 11.8 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2616) zinc_ribbon_2 PF13240.6 ETO18539.1 - 0.087 12.6 6.3 0.18 11.6 6.3 1.6 1 0 0 1 1 1 0 zinc-ribbon domain UPF0547 PF10571.9 ETO18539.1 - 0.43 10.7 5.1 0.99 9.5 5.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0547 Sulfatase PF00884.23 ETO18540.1 - 1.1e-29 103.8 0.0 1.3e-29 103.6 0.0 1.0 1 0 0 1 1 1 1 Sulfatase RhoGAP PF00620.27 ETO18541.1 - 0.00022 21.1 0.0 0.00043 20.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain CDC45 PF02724.14 ETO18541.1 - 0.0058 15.0 3.3 0.075 11.3 3.1 2.0 2 0 0 2 2 2 2 CDC45-like protein F_actin_bund_C PF18060.1 ETO18542.1 - 3.4e-22 78.4 11.9 6.8e-22 77.4 11.9 1.5 1 0 0 1 1 1 1 F actin bundling C terminal DUF4349 PF14257.6 ETO18542.1 - 0.057 12.9 1.4 0.078 12.4 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) FapA PF03961.13 ETO18542.1 - 0.086 11.4 3.7 0.1 11.2 3.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A CODH_A_N PF18537.1 ETO18542.1 - 0.18 11.8 0.6 11 6.1 0.0 2.4 1 1 0 2 2 2 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain HR1 PF02185.16 ETO18542.1 - 0.28 11.3 8.6 1.3 9.2 0.1 2.6 2 1 0 2 2 2 0 Hr1 repeat DUF2408 PF10303.9 ETO18542.1 - 0.88 10.1 7.1 1.5 9.4 7.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2408) Nsp1_C PF05064.13 ETO18542.1 - 1.1 9.1 8.8 7.3 6.4 0.6 2.3 1 1 1 2 2 2 0 Nsp1-like C-terminal region DUF3886 PF13025.6 ETO18542.1 - 3.2 8.0 11.4 1 9.6 8.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) GSHPx PF00255.19 ETO18543.1 - 2.3e-34 117.2 0.0 4.4e-34 116.3 0.0 1.4 1 0 0 1 1 1 1 Glutathione peroxidase AhpC-TSA PF00578.21 ETO18543.1 - 0.00022 21.2 0.2 0.0011 18.9 0.1 1.9 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ETO18543.1 - 0.0012 18.6 0.0 0.0018 18.0 0.0 1.3 1 0 0 1 1 1 1 Redoxin Cyclin_C PF02984.19 ETO18544.1 - 0.017 15.2 0.1 0.045 13.8 0.1 1.8 1 0 0 1 1 1 0 Cyclin, C-terminal domain OATP PF03137.20 ETO18545.1 - 1 7.6 2.5 1.7 6.9 2.5 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF4746 PF15928.5 ETO18545.1 - 1.4 8.2 12.6 2.4 7.5 12.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RasGEF_N PF00618.20 ETO18545.1 - 1.8 8.9 0.0 1.8 8.9 0.0 3.4 4 0 0 4 4 4 0 RasGEF N-terminal motif UQ_con PF00179.26 ETO18546.1 - 2.1e-10 40.4 0.5 2.7e-10 40.0 0.5 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETO18546.1 - 2.4e-05 24.6 0.0 3e-05 24.3 0.0 1.2 1 0 0 1 1 1 1 RWD domain ClpB_D2-small PF10431.9 ETO18548.1 - 1.3e-07 31.6 0.2 2.2e-07 30.8 0.2 1.4 1 0 0 1 1 1 1 C-terminal, D2-small domain, of ClpB protein DUF5436 PF17504.2 ETO18548.1 - 0.067 13.5 1.5 0.088 13.1 1.5 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5436) DUF3340 PF11818.8 ETO18548.1 - 0.12 12.5 0.6 0.19 11.8 0.0 1.6 2 0 0 2 2 2 0 C-terminal domain of tail specific protease (DUF3340) Asp_protease PF09668.10 ETO18549.1 - 1.6e-18 66.7 1.5 6.1e-14 51.9 0.2 2.4 1 1 0 2 2 2 2 Aspartyl protease gag-asp_proteas PF13975.6 ETO18549.1 - 4.8e-06 27.0 0.1 5.6e-05 23.6 0.0 2.2 2 0 0 2 2 2 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ETO18549.1 - 0.0024 18.5 0.1 0.011 16.4 0.0 2.0 2 1 0 2 2 2 1 Aspartyl protease RicinB_lectin_2 PF14200.6 ETO18550.1 - 2.5e-15 56.9 3.3 3.8e-14 53.2 1.6 2.9 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ETO18550.1 - 0.0012 19.1 3.0 0.0013 19.0 1.3 1.8 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Agglutinin PF07468.11 ETO18550.1 - 0.11 12.7 2.5 0.098 12.9 1.1 1.6 2 0 0 2 2 2 0 Agglutinin domain Exo_endo_phos PF03372.23 ETO18551.1 - 5.9e-06 26.0 0.1 0.00019 21.0 0.1 2.3 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Chorion_2 PF03964.15 ETO18551.1 - 0.022 15.6 5.5 0.061 14.2 5.5 1.8 1 0 0 1 1 1 0 Chorion family 2 CCSAP PF15748.5 ETO18551.1 - 0.29 11.3 25.3 0.47 10.6 25.3 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated C_Hendra PF16821.5 ETO18551.1 - 0.61 10.0 4.2 1.4 8.8 4.2 1.6 1 0 0 1 1 1 0 C protein from hendra and measles viruses DUF4746 PF15928.5 ETO18551.1 - 0.75 9.2 7.0 1.1 8.6 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) AF-4 PF05110.13 ETO18551.1 - 2.4 6.1 34.1 3.6 5.6 34.1 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF936 PF06075.12 ETO18551.1 - 5 5.9 26.6 7.1 5.4 26.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) ALMT PF11744.8 ETO18551.1 - 7.6 5.2 16.6 11 4.7 16.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Ndc1_Nup PF09531.10 ETO18551.1 - 9.5 4.8 10.1 16 4.1 10.1 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ATP-synt_E_2 PF08112.11 ETO18552.1 - 0.25 11.6 1.7 2 8.8 0.2 2.4 3 0 0 3 3 3 0 ATP synthase epsilon subunit DUF4710 PF15828.5 ETO18554.1 - 0.0084 16.2 1.5 0.016 15.3 1.5 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4710) DUF2497 PF10691.9 ETO18554.1 - 0.038 14.4 0.4 0.18 12.3 0.4 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2497) Phosphoesterase PF04185.14 ETO18555.1 - 4.2e-24 85.4 1.3 4.9e-24 85.2 1.3 1.2 1 1 0 1 1 1 1 Phosphoesterase family PriC PF07445.12 ETO18555.1 - 0.16 11.8 0.9 0.24 11.3 0.9 1.2 1 0 0 1 1 1 0 Primosomal replication protein priC DRIM PF07539.12 ETO18556.1 - 0.0035 15.7 1.5 0.0046 15.3 1.5 1.2 1 0 0 1 1 1 1 Down-regulated in metastasis DUF5578 PF17741.1 ETO18556.1 - 0.0057 16.1 0.7 0.024 14.1 0.1 2.1 1 1 1 2 2 2 1 Family of unknown function (DUF5578) Arm PF00514.23 ETO18556.1 - 0.31 11.2 4.6 1.1 9.4 0.0 3.1 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat Flexi_CP PF00286.20 ETO18557.1 - 0.022 14.7 0.3 0.044 13.7 0.3 1.4 1 0 0 1 1 1 0 Viral coat protein HLH PF00010.26 ETO18558.1 - 0.0019 18.1 1.6 0.0051 16.7 1.6 1.7 1 0 0 1 1 1 1 Helix-loop-helix DNA-binding domain VWA_CoxE PF05762.14 ETO18559.1 - 0.005 16.2 0.0 0.0065 15.9 0.0 1.2 1 0 0 1 1 1 1 VWA domain containing CoxE-like protein Thioredoxin_6 PF13848.6 ETO18559.1 - 0.02 14.8 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 Thioredoxin-like domain VWA_2 PF13519.6 ETO18559.1 - 0.098 13.3 0.0 0.19 12.4 0.0 1.4 1 1 0 1 1 1 0 von Willebrand factor type A domain IQ PF00612.27 ETO18560.1 - 1.6 8.7 6.3 48 4.1 0.0 4.4 4 0 0 4 4 4 0 IQ calmodulin-binding motif DENN PF02141.21 ETO18561.1 - 2.5e-32 112.4 2.2 2.5e-32 112.4 2.2 1.5 2 0 0 2 2 2 1 DENN (AEX-3) domain dDENN PF03455.19 ETO18561.1 - 8.3e-13 48.1 4.0 1.9e-12 47.0 4.0 1.7 1 0 0 1 1 1 1 dDENN domain Macoilin PF09726.9 ETO18561.1 - 0.85 8.1 12.6 1.1 7.7 12.6 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO18561.1 - 1.1 8.0 5.0 1.6 7.4 5.0 1.3 1 0 0 1 1 1 0 Presenilin MAP70 PF07058.11 ETO18561.1 - 6.2 5.4 11.2 8.2 5.0 11.2 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 uDENN PF03456.18 ETO18562.1 - 8.5e-10 39.2 0.1 2e-09 38.1 0.0 1.6 2 0 0 2 2 2 1 uDENN domain SRP54 PF00448.22 ETO18562.1 - 0.015 15.0 0.0 0.022 14.4 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ArfGap PF01412.18 ETO18563.1 - 3.6e-23 81.9 1.6 4.8e-23 81.5 1.6 1.1 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf zf-B_box PF00643.24 ETO18563.1 - 4.2 7.6 8.8 12 6.2 8.8 1.7 1 1 0 1 1 1 0 B-box zinc finger HEAT_EZ PF13513.6 ETO18564.1 - 1.6e-08 34.9 1.9 0.13 12.8 0.2 4.3 3 1 1 4 4 4 2 HEAT-like repeat HEAT PF02985.22 ETO18564.1 - 2.9e-08 33.3 1.9 0.28 11.6 0.0 4.6 4 0 0 4 4 4 2 HEAT repeat Cnd1 PF12717.7 ETO18564.1 - 2.6e-06 27.6 5.0 0.00013 22.0 0.1 3.6 2 2 1 4 4 4 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO18564.1 - 1.8e-05 25.0 3.8 0.012 16.0 0.1 3.4 3 1 1 4 4 4 2 HEAT repeats UNC45-central PF11701.8 ETO18564.1 - 3.4e-05 23.8 1.1 0.025 14.5 0.1 2.7 2 2 0 2 2 2 2 Myosin-binding striated muscle assembly central RTP1_C1 PF10363.9 ETO18564.1 - 0.00045 20.4 0.1 0.0033 17.6 0.0 2.2 2 0 0 2 2 2 1 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO18564.1 - 0.0011 19.6 0.1 0.14 12.8 0.0 2.9 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region UME PF08064.13 ETO18564.1 - 0.012 15.5 1.5 0.065 13.1 0.0 2.8 4 0 0 4 4 4 0 UME (NUC010) domain Ecm29 PF13001.7 ETO18564.1 - 0.025 13.3 0.6 1.1 7.9 0.0 2.9 3 0 0 3 3 3 0 Proteasome stabiliser Xpo1 PF08389.12 ETO18564.1 - 0.12 12.4 0.2 0.67 10.0 0.0 2.3 2 1 0 2 2 2 0 Exportin 1-like protein TMF_DNA_bd PF12329.8 ETO18565.1 - 0.0021 18.0 6.5 0.004 17.1 6.5 1.5 1 0 0 1 1 1 1 TATA element modulatory factor 1 DNA binding K-box PF01486.17 ETO18565.1 - 0.011 15.9 12.7 0.017 15.3 12.1 1.6 1 1 1 2 2 2 0 K-box region Muted PF14942.6 ETO18565.1 - 0.013 15.8 3.5 0.018 15.4 3.5 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein hGDE_central PF14702.6 ETO18565.1 - 0.03 14.0 0.3 0.038 13.7 0.3 1.1 1 0 0 1 1 1 0 Central domain of human glycogen debranching enzyme APG6_N PF17675.1 ETO18565.1 - 0.03 14.8 8.4 0.04 14.4 8.4 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 ETO18565.1 - 0.063 11.9 3.2 0.072 11.7 3.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 ETO18565.1 - 0.08 12.3 2.1 0.1 11.9 2.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF874 PF05917.11 ETO18565.1 - 0.092 11.8 5.8 0.16 11.0 5.8 1.3 1 1 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Exonuc_VII_L PF02601.15 ETO18565.1 - 0.18 11.3 2.1 0.21 11.1 2.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit TolA_bind_tri PF16331.5 ETO18565.1 - 0.88 9.7 9.1 3 8.0 4.9 2.2 1 1 1 2 2 2 0 TolA binding protein trimerisation YlqD PF11068.8 ETO18565.1 - 0.96 9.8 11.0 0.23 11.8 5.0 2.0 1 1 1 2 2 2 0 YlqD protein ACCA PF03255.14 ETO18565.1 - 1.3 8.9 5.7 2.2 8.1 4.1 1.8 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit SlyX PF04102.12 ETO18565.1 - 3.4 8.4 10.0 15 6.3 4.1 2.4 1 1 1 2 2 2 0 SlyX Cyclin PF08613.11 ETO18566.1 - 0.013 15.9 0.4 0.013 15.9 0.4 1.8 2 0 0 2 2 2 0 Cyclin ADIP PF11559.8 ETO18566.1 - 0.016 15.3 9.9 0.016 15.3 9.9 2.9 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding Adeno_E3 PF06040.11 ETO18566.1 - 0.035 14.3 2.2 0.1 12.8 0.0 2.6 2 1 2 4 4 4 0 Adenovirus E3 protein PH PF00169.29 ETO18567.1 - 1.7e-06 28.5 1.3 7.6e-06 26.4 1.0 2.3 2 1 0 2 2 2 1 PH domain Ribosomal_L12_N PF16320.5 ETO18567.1 - 0.012 15.3 0.1 0.021 14.5 0.1 1.4 1 0 0 1 1 1 0 Ribosomal protein L7/L12 dimerisation domain PH_6 PF15406.6 ETO18567.1 - 0.023 15.0 0.0 0.043 14.1 0.0 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ETO18567.1 - 0.091 13.2 0.5 13 6.3 0.2 3.1 2 1 1 3 3 3 0 Pleckstrin homology domain KBP_C PF12309.8 ETO18568.1 - 1.2e-57 196.1 11.3 1.5e-56 192.4 11.3 2.1 1 1 0 1 1 1 1 KIF-1 binding protein C terminal Ada3 PF10198.9 ETO18568.1 - 0.005 17.0 1.4 0.011 15.9 1.4 1.6 1 0 0 1 1 1 1 Histone acetyltransferases subunit 3 Presenilin PF01080.17 ETO18569.1 - 5.1 5.8 7.0 8 5.1 7.0 1.3 1 0 0 1 1 1 0 Presenilin CCDC-167 PF15188.6 ETO18570.1 - 0.41 11.0 5.5 0.65 10.4 1.4 2.2 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Fib_alpha PF08702.10 ETO18571.1 - 0.0013 18.9 5.5 0.0013 18.9 5.5 4.3 1 1 3 5 5 5 3 Fibrinogen alpha/beta chain family APG6_N PF17675.1 ETO18571.1 - 0.012 16.1 3.7 0.012 16.1 3.7 3.6 2 1 0 3 3 2 0 Apg6 coiled-coil region DUF1216 PF06746.11 ETO18571.1 - 0.013 15.5 13.0 0.043 13.8 1.8 4.0 2 2 1 4 4 4 0 Protein of unknown function (DUF1216) ECM11 PF15463.6 ETO18571.1 - 0.028 15.0 3.1 0.028 15.0 3.1 3.4 2 1 2 4 4 3 0 Extracellular mutant protein 11 Lact-deh-memb PF09330.11 ETO18571.1 - 0.039 13.3 5.2 0.026 13.9 0.9 2.2 2 0 0 2 2 2 0 D-lactate dehydrogenase, membrane binding ABC_tran_CTD PF16326.5 ETO18571.1 - 0.065 13.5 28.3 0.047 14.0 3.3 5.6 3 2 0 5 5 5 0 ABC transporter C-terminal domain Phi-29_GP16_7 PF06720.11 ETO18571.1 - 0.1 12.5 2.8 0.27 11.1 0.9 2.6 2 0 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 DUF724 PF05266.14 ETO18571.1 - 0.16 11.8 26.2 0.1 12.4 2.3 4.1 1 1 2 3 3 3 0 Protein of unknown function (DUF724) EzrA PF06160.12 ETO18571.1 - 0.29 9.3 32.4 0.14 10.3 13.1 3.3 2 1 0 3 3 3 0 Septation ring formation regulator, EzrA HSBP1 PF06825.12 ETO18571.1 - 0.48 10.3 7.0 2.4 8.1 0.3 3.8 4 0 0 4 4 4 0 Heat shock factor binding protein 1 Spc7 PF08317.11 ETO18571.1 - 0.49 9.2 30.9 0.13 11.1 3.1 3.9 1 1 3 4 4 4 0 Spc7 kinetochore protein PSI_PsaF PF02507.15 ETO18571.1 - 0.59 10.0 0.0 0.59 10.0 0.0 2.4 3 0 0 3 3 3 0 Photosystem I reaction centre subunit III DUF4164 PF13747.6 ETO18571.1 - 0.63 10.4 14.3 2.1 8.7 0.4 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4164) Bcr-Abl_Oligo PF09036.10 ETO18571.1 - 5.8 7.0 6.1 23 5.1 0.0 4.2 3 2 1 4 4 4 0 Bcr-Abl oncoprotein oligomerisation domain RGS PF00615.19 ETO18572.1 - 0.0066 16.7 0.1 0.01 16.1 0.1 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Macoilin PF09726.9 ETO18572.1 - 0.063 11.8 7.4 0.075 11.6 7.4 1.1 1 0 0 1 1 1 0 Macoilin family PI3K_1B_p101 PF10486.9 ETO18572.1 - 0.56 7.9 6.1 0.63 7.7 6.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TFB6 PF17110.5 ETO18572.1 - 1.3 8.7 11.4 0.19 11.5 4.3 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Presenilin PF01080.17 ETO18572.1 - 2.4 6.8 5.2 3.6 6.3 5.2 1.3 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 ETO18573.1 - 3.4e-10 39.4 0.0 5.2e-10 38.8 0.0 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1 PF07690.16 ETO18574.1 - 1.3e-05 24.3 11.2 1.9e-05 23.8 11.2 1.2 1 1 0 1 1 1 1 Major Facilitator Superfamily MFS_1_like PF12832.7 ETO18574.1 - 0.00094 18.1 3.0 0.0021 17.0 3.0 1.6 1 1 0 1 1 1 1 MFS_1 like family Sugar_tr PF00083.24 ETO18574.1 - 0.076 11.9 15.2 0.52 9.1 6.3 2.0 1 1 0 2 2 2 0 Sugar (and other) transporter CitMHS PF03600.16 ETO18574.1 - 0.08 12.1 5.9 0.46 9.6 5.9 1.9 1 1 0 1 1 1 0 Citrate transporter DUF4719 PF15843.5 ETO18574.1 - 0.092 12.9 0.2 0.13 12.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4719) Cation_efflux PF01545.21 ETO18575.1 - 6.7e-08 32.5 4.3 9.4e-08 32.0 4.3 1.2 1 0 0 1 1 1 1 Cation efflux family Arm PF00514.23 ETO18576.1 - 1.2e-05 25.1 0.0 1 9.5 0.0 3.5 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat CHU_C PF13585.6 ETO18576.1 - 0.046 13.8 0.1 2.7 8.1 0.0 2.4 2 0 0 2 2 2 0 C-terminal domain of CHU protein family Turandot PF07240.11 ETO18577.1 - 0.24 11.4 0.0 0.33 11.0 0.0 1.2 1 0 0 1 1 1 0 Stress-inducible humoral factor Turandot NopRA1 PF16201.5 ETO18578.1 - 0.072 12.7 0.1 9.7 5.7 0.0 2.2 2 0 0 2 2 2 0 Nucleolar pre-ribosomal-associated protein 1 DUF3402 PF11882.8 ETO18579.1 - 0.03 13.4 0.2 0.035 13.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) Spore_GerAC PF05504.11 ETO18579.1 - 0.049 13.9 0.1 0.058 13.6 0.1 1.2 1 0 0 1 1 1 0 Spore germination B3/ GerAC like, C-terminal ApoLp-III PF07464.11 ETO18579.1 - 0.067 13.3 0.6 0.077 13.1 0.6 1.1 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) Remorin_C PF03763.13 ETO18579.1 - 0.14 12.1 0.1 0.2 11.5 0.1 1.2 1 0 0 1 1 1 0 Remorin, C-terminal region RabGAP-TBC PF00566.18 ETO18581.1 - 1e-15 58.0 8.1 1e-15 58.0 8.1 1.5 1 1 1 2 2 2 1 Rab-GTPase-TBC domain Ribosomal_S15 PF00312.22 ETO18581.1 - 0.39 10.9 3.6 0.72 10.1 3.6 1.4 1 0 0 1 1 1 0 Ribosomal protein S15 TMEM154 PF15102.6 ETO18582.1 - 0.029 14.3 0.2 0.029 14.3 0.2 2.4 2 1 0 2 2 2 0 TMEM154 protein family LMBR1 PF04791.16 ETO18582.1 - 0.098 11.5 9.0 0.11 11.3 9.0 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein LAP1C PF05609.12 ETO18582.1 - 0.17 10.9 14.8 0.18 10.8 14.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PI3K_1B_p101 PF10486.9 ETO18582.1 - 0.24 9.1 9.3 0.27 9.0 9.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit JCAD PF15351.6 ETO18582.1 - 0.94 7.2 13.3 1.2 6.9 13.3 1.0 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease Neur_chan_memb PF02932.16 ETO18582.1 - 2.1 8.3 6.7 3 7.8 6.7 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Afaf PF15339.6 ETO18582.1 - 3.8 7.2 14.1 0.69 9.6 8.6 2.0 1 1 1 2 2 2 0 Acrosome formation-associated factor UPF0565 PF10561.9 ETO18582.1 - 4.7 6.3 11.2 0.53 9.4 6.4 1.6 1 1 1 2 2 2 0 Uncharacterised protein family UPF0565 WD40 PF00400.32 ETO18585.1 - 8.4e-40 134.0 24.4 6.3e-06 26.8 0.3 7.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO18585.1 - 1.5e-15 56.8 3.6 0.018 13.7 0.0 6.0 1 1 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO18585.1 - 1.6e-10 41.2 5.2 0.21 11.9 0.0 7.3 4 3 3 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO18585.1 - 1.4e-06 28.8 3.9 4.5e-06 27.3 3.9 1.9 1 0 0 1 1 1 1 TRAF-type zinc finger Peptidase_S46 PF10459.9 ETO18585.1 - 1.2 7.7 11.1 1.9 7.1 11.1 1.1 1 0 0 1 1 1 0 Peptidase S46 HALZ PF02183.18 ETO18585.1 - 2.3 8.5 15.2 3.8 7.8 2.4 3.6 2 0 0 2 2 2 0 Homeobox associated leucine zipper zf-TRAF PF02176.18 ETO18586.1 - 9.2e-07 29.5 1.0 9.2e-07 29.5 1.0 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger DNAJ_related PF12339.8 ETO18586.1 - 0.63 10.3 6.9 9.8 6.4 0.1 2.7 1 1 1 2 2 2 0 DNA-J related protein Rap1a PF18602.1 ETO18587.1 - 0.015 15.6 0.1 0.03 14.6 0.1 1.5 1 0 0 1 1 1 0 Rap1a immunity proteins CAP_N PF01213.19 ETO18587.1 - 0.025 14.1 0.1 0.028 13.9 0.1 1.1 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Glycoprotein PF03409.15 ETO18587.1 - 0.029 13.2 2.0 0.033 13.0 2.0 1.1 1 0 0 1 1 1 0 Transmembrane glycoprotein Mito_fiss_reg PF05308.11 ETO18587.1 - 0.12 12.5 1.7 0.14 12.2 1.7 1.1 1 0 0 1 1 1 0 Mitochondrial fission regulator PRIMA1 PF16101.5 ETO18587.1 - 0.19 11.8 4.0 0.25 11.4 4.0 1.2 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 SMC_N PF02463.19 ETO18588.1 - 4.4e-07 29.6 0.1 0.0013 18.3 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_22 PF13401.6 ETO18588.1 - 2.8e-05 24.4 0.0 0.0031 17.8 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO18588.1 - 3.1e-05 24.4 0.0 0.0013 19.2 0.0 2.5 2 0 0 2 2 2 1 AAA ATPase domain ABC_tran PF00005.27 ETO18588.1 - 0.00018 22.1 5.2 1.1 9.8 0.0 4.8 4 1 1 5 5 5 2 ABC transporter AAA PF00004.29 ETO18588.1 - 0.00023 21.6 0.0 0.74 10.2 0.1 3.1 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) Chromo PF00385.24 ETO18588.1 - 0.0025 17.7 0.5 0.0052 16.7 0.5 1.5 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain AAA_24 PF13479.6 ETO18588.1 - 0.024 14.4 0.1 1.6 8.4 0.0 3.1 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 ETO18588.1 - 0.035 14.0 0.1 0.12 12.2 0.0 1.9 2 0 0 2 2 2 0 RsgA GTPase AAA_19 PF13245.6 ETO18588.1 - 0.046 14.1 0.0 3.4 8.0 0.0 3.0 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO18588.1 - 0.057 13.2 0.1 0.15 11.8 0.1 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain T2SSE PF00437.20 ETO18588.1 - 0.071 12.2 0.0 0.16 11.0 0.0 1.5 1 0 0 1 1 1 0 Type II/IV secretion system protein RNA_helicase PF00910.22 ETO18588.1 - 0.082 13.3 0.0 10 6.6 0.0 3.0 2 0 0 2 2 2 0 RNA helicase AAA_28 PF13521.6 ETO18588.1 - 0.1 12.8 0.2 7.9 6.7 0.1 3.1 3 0 0 3 3 3 0 AAA domain AAA_14 PF13173.6 ETO18588.1 - 0.16 12.0 0.5 60 3.7 0.0 3.7 3 1 0 3 3 3 0 AAA domain AAA_33 PF13671.6 ETO18588.1 - 0.19 11.9 0.2 0.19 11.9 0.2 3.4 3 0 0 3 3 3 0 AAA domain YL1 PF05764.13 ETO18588.1 - 1.3 9.1 15.7 2.5 8.2 15.7 1.4 1 0 0 1 1 1 0 YL1 nuclear protein Dsh_C PF12316.8 ETO18588.1 - 4.8 7.5 12.2 3.1 8.2 2.8 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal LDcluster4 PF18306.1 ETO18589.1 - 0.097 12.3 0.3 0.29 10.7 0.0 1.9 2 0 0 2 2 2 0 SLOG cluster4 family DASH_Dad1 PF08649.10 ETO18589.1 - 5.5 7.3 10.0 5.4 7.3 0.1 4.9 4 0 0 4 4 4 0 DASH complex subunit Dad1 FliS PF02561.14 ETO18589.1 - 8.5 6.7 13.7 0.28 11.5 0.3 3.8 4 0 0 4 4 4 0 Flagellar protein FliS Ras PF00071.22 ETO18590.1 - 2e-13 50.3 5.1 5e-05 22.9 0.1 4.6 3 1 0 4 4 4 3 Ras family Roc PF08477.13 ETO18590.1 - 0.00022 21.4 3.3 0.0062 16.7 0.0 3.9 5 0 0 5 5 5 1 Ras of Complex, Roc, domain of DAPkinase Syncollin PF15138.6 ETO18590.1 - 0.078 13.2 0.1 19 5.5 0.0 3.2 3 0 0 3 3 3 0 Syncollin AAA_18 PF13238.6 ETO18590.1 - 0.12 12.9 0.6 5.1 7.7 1.0 2.3 2 0 0 2 2 2 0 AAA domain Macoilin PF09726.9 ETO18590.1 - 0.26 9.8 10.1 0.43 9.1 10.1 1.3 1 0 0 1 1 1 0 Macoilin family Methyltransf_12 PF08242.12 ETO18590.1 - 1.3 9.8 4.0 3.7 8.3 4.0 1.9 1 0 0 1 1 1 0 Methyltransferase domain Zip PF02535.22 ETO18590.1 - 1.5 7.9 4.3 2.1 7.5 4.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Hydrolase PF00702.26 ETO18591.1 - 4.4e-24 85.9 2.5 1.9e-20 74.1 2.5 3.3 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 ETO18591.1 - 6.7e-23 81.3 0.3 1.1e-22 80.6 0.3 1.3 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ETO18591.1 - 8.4e-18 64.2 0.0 1.9e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETO18591.1 - 3.5e-06 26.9 1.2 0.0021 17.8 0.6 3.0 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO18591.1 - 0.034 14.5 0.1 0.21 12.0 0.1 2.3 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase CDC24_OB1 PF17246.2 ETO18592.1 - 0.049 13.8 0.9 0.088 12.9 0.9 1.4 1 0 0 1 1 1 0 Cell division control protein 24, OB domain 1 DEP PF00610.21 ETO18593.1 - 1.6e-13 50.5 0.0 4.3e-13 49.1 0.0 1.8 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_7 PF13499.6 ETO18593.1 - 3.1e-10 40.4 2.8 0.0001 22.7 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO18593.1 - 0.00052 19.4 3.2 0.042 13.4 0.0 3.5 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 ETO18593.1 - 0.0006 19.5 6.8 0.018 14.9 0.1 3.9 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 ETO18593.1 - 0.0012 18.2 0.1 0.0095 15.4 0.1 2.5 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO18593.1 - 0.0079 16.0 0.4 0.31 10.9 0.1 2.6 2 0 0 2 2 2 1 EF-hand domain pair Clat_adaptor_s PF01217.20 ETO18594.1 - 1.4e-37 128.8 11.6 1.9e-36 125.1 11.6 2.0 1 1 0 1 1 1 1 Clathrin adaptor complex small chain MRG PF05712.13 ETO18594.1 - 0.057 12.7 2.3 0.17 11.2 2.3 1.9 1 1 0 1 1 1 0 MRG Pkinase PF00069.25 ETO18595.1 - 7.1e-05 22.3 0.0 0.013 14.9 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain RRM_1 PF00076.22 ETO18596.1 - 0.00017 21.3 0.1 0.00037 20.3 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DIE2_ALG10 PF04922.12 ETO18596.1 - 0.02 14.2 0.0 0.02 14.2 0.0 1.3 2 0 0 2 2 2 0 DIE2/ALG10 family PH PF00169.29 ETO18597.1 - 4.4e-09 36.8 14.5 2.3e-06 28.0 5.7 3.9 3 1 0 3 3 3 2 PH domain Menin PF05053.13 ETO18597.1 - 0.43 8.9 10.1 0.67 8.2 10.1 1.3 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO18597.1 - 2.3 8.8 22.9 0.18 12.3 17.1 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain PH PF00169.29 ETO18598.1 - 2e-25 89.3 5.1 9.6e-09 35.7 0.2 3.3 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 ETO18598.1 - 1.4e-11 44.8 10.5 1.2e-05 25.7 0.4 3.3 3 0 0 3 3 3 3 Pleckstrin homology domain PH_8 PF15409.6 ETO18598.1 - 1.4e-10 41.3 0.8 0.0074 16.5 0.0 3.5 3 0 0 3 3 3 3 Pleckstrin homology domain PH_3 PF14593.6 ETO18598.1 - 9.8e-09 35.3 1.9 0.057 13.5 0.1 3.2 3 0 0 3 3 3 3 PH domain PH_15 PF17339.2 ETO18598.1 - 0.021 14.7 0.6 4 7.4 0.1 2.4 2 0 0 2 2 2 0 PH domain E1-E2_ATPase PF00122.20 ETO18599.1 - 1.2e-31 109.7 0.4 1.8e-29 102.6 0.2 2.1 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 ETO18599.1 - 6.2e-13 48.2 0.0 1e-12 47.5 0.0 1.4 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Rad9 PF04139.13 ETO18600.1 - 1.9e-12 47.2 0.5 1.9e-12 47.2 0.5 2.0 2 1 0 2 2 2 1 Rad9 TMEM190 PF15431.6 ETO18600.1 - 0.0035 17.5 1.5 0.012 15.8 0.3 2.1 2 0 0 2 2 2 1 Transmembrane protein 190 Ninjurin PF04923.12 ETO18600.1 - 0.047 13.6 0.4 0.12 12.4 0.4 1.7 1 0 0 1 1 1 0 Ninjurin Orf78 PF06024.12 ETO18600.1 - 0.054 13.8 0.5 0.71 10.2 0.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Pex2_Pex12 PF04757.14 ETO18600.1 - 0.066 12.8 2.3 0.061 12.9 0.9 1.6 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region LRR_6 PF13516.6 ETO18601.1 - 0.00099 19.0 2.4 0.036 14.1 0.0 3.4 4 0 0 4 4 4 1 Leucine Rich repeat ETRAMP PF09716.10 ETO18602.1 - 0.071 13.2 1.4 0.22 11.6 1.4 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2116 PF09889.9 ETO18602.1 - 0.2 11.7 0.0 2.6 8.1 0.0 2.5 2 1 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) Pap_E4 PF02711.14 ETO18602.1 - 9.7 7.2 11.1 0.16 12.9 1.5 2.6 3 0 0 3 3 3 0 E4 protein DNA_ligase_A_N PF04675.14 ETO18603.1 - 3.2e-37 128.5 0.2 3.2e-37 128.5 0.2 1.7 2 0 0 2 2 2 1 DNA ligase N terminus DNA_ligase_A_M PF01068.21 ETO18603.1 - 2.4e-17 63.3 0.8 4.3e-17 62.4 0.0 1.8 2 0 0 2 2 2 1 ATP dependent DNA ligase domain Gti1_Pac2 PF09729.9 ETO18603.1 - 4.7 7.3 11.2 8.7 6.4 11.2 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family DNA_ligase_A_M PF01068.21 ETO18604.1 - 7.8e-37 126.9 0.1 1.1e-36 126.4 0.1 1.2 1 0 0 1 1 1 1 ATP dependent DNA ligase domain DNA_ligase_A_C PF04679.15 ETO18604.1 - 9.1e-21 74.3 0.0 1.5e-20 73.6 0.0 1.3 1 0 0 1 1 1 1 ATP dependent DNA ligase C terminal region DUF4388 PF14332.6 ETO18604.1 - 0.099 12.9 0.0 0.22 11.8 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4388) RNA_ligase PF09414.10 ETO18604.1 - 0.13 12.6 0.0 0.23 11.8 0.0 1.4 1 0 0 1 1 1 0 RNA ligase CIAPIN1 PF05093.13 ETO18605.1 - 1.6e-17 63.8 21.5 1.1e-14 54.8 17.5 3.2 2 1 0 2 2 2 1 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Methyltransf_23 PF13489.6 ETO18605.1 - 0.002 18.0 0.0 0.0034 17.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO18605.1 - 0.01 15.6 0.0 0.02 14.7 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain DRE2_N PF16803.5 ETO18605.1 - 0.013 15.7 0.0 0.025 14.8 0.0 1.4 1 0 0 1 1 1 0 Fe-S cluster assembly protein DRE2 N-terminus Methyltransf_11 PF08241.12 ETO18605.1 - 0.038 14.6 0.0 0.087 13.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 ETO18605.1 - 0.072 12.4 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family CD36 PF01130.21 ETO18606.1 - 1.4e-23 83.2 0.0 1.6e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 CD36 family HcyBio PF01837.16 ETO18606.1 - 0.049 12.5 0.0 0.072 11.9 0.0 1.2 1 0 0 1 1 1 0 Homocysteine biosynthesis enzyme, sulfur-incorporation LAP1C PF05609.12 ETO18607.1 - 6.3e-05 22.3 3.7 8e-05 21.9 3.7 1.0 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Tmemb_cc2 PF10267.9 ETO18607.1 - 0.0043 16.2 4.7 0.0043 16.2 4.7 1.6 2 0 0 2 2 2 1 Predicted transmembrane and coiled-coil 2 protein Fib_alpha PF08702.10 ETO18607.1 - 0.0093 16.2 1.5 0.0093 16.2 1.5 1.9 2 0 0 2 2 2 1 Fibrinogen alpha/beta chain family DUF16 PF01519.16 ETO18607.1 - 0.01 16.3 1.8 0.021 15.3 1.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF16 PKHD_C PF18331.1 ETO18607.1 - 0.011 15.7 0.1 0.042 13.9 0.1 2.0 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain Spc24 PF08286.11 ETO18607.1 - 0.012 15.8 0.3 0.012 15.8 0.3 1.8 2 0 0 2 2 1 0 Spc24 subunit of Ndc80 SlyX PF04102.12 ETO18607.1 - 0.014 16.0 3.8 0.053 14.2 3.8 1.9 1 0 0 1 1 1 0 SlyX FapA PF03961.13 ETO18607.1 - 0.017 13.7 1.1 0.021 13.4 1.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Rx_N PF18052.1 ETO18607.1 - 0.018 15.3 1.3 0.035 14.4 1.3 1.5 1 0 0 1 1 1 0 Rx N-terminal domain PI3K_P85_iSH2 PF16454.5 ETO18607.1 - 0.02 14.5 5.1 0.06 13.0 4.0 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain PriC PF07445.12 ETO18607.1 - 0.02 14.8 4.2 0.043 13.8 4.2 1.5 1 0 0 1 1 1 0 Primosomal replication protein priC DUF4446 PF14584.6 ETO18607.1 - 0.042 13.8 2.5 0.34 10.9 2.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) CorA PF01544.18 ETO18607.1 - 0.069 12.4 3.2 0.13 11.6 3.2 1.4 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DivIC PF04977.15 ETO18607.1 - 0.077 12.8 5.7 0.19 11.5 5.7 1.6 1 0 0 1 1 1 0 Septum formation initiator ACCA PF03255.14 ETO18607.1 - 0.38 10.6 3.5 0.65 9.9 2.7 1.8 1 1 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF948 PF06103.11 ETO18607.1 - 0.47 10.7 3.2 1.6 9.0 0.9 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) HemX PF04375.14 ETO18607.1 - 1.2 8.3 9.5 1.1 8.5 8.3 1.4 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FlaC_arch PF05377.11 ETO18607.1 - 1.4 9.4 4.5 1.1 9.7 2.5 2.0 2 0 0 2 2 1 0 Flagella accessory protein C (FlaC) TolA_bind_tri PF16331.5 ETO18607.1 - 5.8 7.1 9.3 0.54 10.4 4.6 1.7 2 0 0 2 2 1 0 TolA binding protein trimerisation ERGIC_N PF13850.6 ETO18609.1 - 1.1e-24 86.6 0.2 2e-24 85.8 0.2 1.4 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Imm68 PF15583.6 ETO18609.1 - 0.004 17.3 0.4 0.0064 16.7 0.4 1.4 1 0 0 1 1 1 1 Immunity protein 68 RNA_pol_Rpc34 PF05158.12 ETO18609.1 - 0.04 13.3 0.1 0.046 13.1 0.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpc34 subunit YqzE PF14038.6 ETO18611.1 - 0.16 12.0 2.4 0.32 11.0 2.4 1.4 1 0 0 1 1 1 0 YqzE-like protein Myosin_head PF00063.21 ETO18614.1 - 5e-27 94.4 0.1 7.1e-27 93.9 0.1 1.2 1 0 0 1 1 1 1 Myosin head (motor domain) WW PF00397.26 ETO18614.1 - 1.6e-09 37.7 4.0 1.5e-08 34.5 2.1 2.4 2 0 0 2 2 2 1 WW domain Intein_splicing PF14890.6 ETO18614.1 - 0.012 15.5 0.2 0.033 14.1 0.0 1.8 2 0 0 2 2 2 0 Intein splicing domain GYF_2 PF14237.6 ETO18614.1 - 0.11 12.3 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 GYF domain 2 CTD_bind PF04818.13 ETO18615.1 - 0.0095 16.7 0.2 0.02 15.7 0.2 1.6 1 0 0 1 1 1 1 RNA polymerase II-binding domain. Zip PF02535.22 ETO18615.1 - 0.076 12.2 0.5 0.093 11.9 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3395 PF11875.8 ETO18616.1 - 6.5e-16 58.6 2.0 3.3e-15 56.3 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3395) SLC12 PF03522.15 ETO18617.1 - 2.3e-19 69.8 0.1 2.3e-19 69.8 0.1 1.6 1 1 1 2 2 2 1 Solute carrier family 12 DP-EP PF08985.11 ETO18618.1 - 0.076 13.2 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 DP-EP family ubiquitin PF00240.23 ETO18620.1 - 6.1e-41 138.0 0.7 3.4e-29 100.4 0.2 2.7 2 0 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETO18620.1 - 4.2e-20 71.4 0.4 1.8e-14 53.3 0.3 2.7 2 0 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Intein_splicing PF14890.6 ETO18620.1 - 7.8e-09 35.6 1.6 2.1e-08 34.2 1.6 1.8 1 0 0 1 1 1 1 Intein splicing domain Hint PF01079.20 ETO18620.1 - 6.1e-08 32.4 0.6 2.7e-07 30.3 0.1 1.9 1 1 1 2 2 2 1 Hint module AXH PF08517.12 ETO18620.1 - 2.3e-07 31.4 1.9 2.8e-07 31.1 0.0 2.1 2 0 0 2 2 1 1 Ataxin-1 and HBP1 module (AXH) Ubiquitin_2 PF14560.6 ETO18620.1 - 1.7e-06 28.4 0.4 4.4e-05 23.8 0.1 2.8 2 0 0 2 2 2 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO18620.1 - 1.4e-05 24.9 0.7 0.004 17.0 0.0 3.0 3 0 0 3 3 3 1 TANK binding kinase 1 ubiquitin-like domain Vint PF14623.6 ETO18620.1 - 2.4e-05 24.2 0.1 5.2e-05 23.1 0.1 1.6 1 0 0 1 1 1 1 Hint-domain Hint_2 PF13403.6 ETO18620.1 - 0.0022 18.3 0.1 0.0064 16.8 0.1 1.8 1 0 0 1 1 1 1 Hint domain PDDEXK_5 PF11645.8 ETO18620.1 - 0.0068 16.4 0.0 0.0068 16.4 0.0 1.7 2 0 0 2 2 1 1 PD-(D/E)XK endonuclease DUF2407 PF10302.9 ETO18620.1 - 0.0076 16.8 5.5 2 9.0 0.0 3.3 3 0 0 3 3 3 2 DUF2407 ubiquitin-like domain zf-DBF PF07535.12 ETO18620.1 - 0.0078 16.3 0.0 0.057 13.6 0.0 2.2 2 0 0 2 2 2 1 DBF zinc finger BSP_II PF05432.11 ETO18620.1 - 0.011 15.4 11.2 0.019 14.7 11.2 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2796 PF10986.8 ETO18620.1 - 0.019 14.9 3.3 0.035 14.1 3.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) FAM176 PF14851.6 ETO18620.1 - 0.03 14.0 4.5 0.068 12.8 4.5 1.5 1 0 0 1 1 1 0 FAM176 family PT-HINT PF07591.11 ETO18620.1 - 0.049 13.9 1.8 0.46 10.7 1.8 2.6 1 1 0 1 1 1 0 Pretoxin HINT domain Rad60-SLD_2 PF13881.6 ETO18620.1 - 0.058 13.5 0.0 0.058 13.5 0.0 2.9 3 1 1 4 4 3 0 Ubiquitin-2 like Rad60 SUMO-like Hom_end_hint PF05203.16 ETO18620.1 - 0.08 12.9 0.1 0.08 12.9 0.1 1.8 2 0 0 2 2 1 0 Hom_end-associated Hint RNA_pol_3_Rpc31 PF11705.8 ETO18620.1 - 0.11 12.8 10.5 0.06 13.6 8.3 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Sporozoite_P67 PF05642.11 ETO18620.1 - 0.15 10.1 5.1 0.23 9.5 5.1 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2722 PF10846.8 ETO18620.1 - 0.34 9.8 4.5 0.5 9.3 4.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Spot_14 PF07084.12 ETO18620.1 - 0.43 10.7 3.0 2.4 8.3 0.8 2.4 2 0 0 2 2 2 0 Thyroid hormone-inducible hepatic protein Spot 14 Pox_Ag35 PF03286.14 ETO18620.1 - 0.93 9.3 8.7 2 8.2 8.7 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RPN2_C PF18004.1 ETO18620.1 - 1.8 8.5 8.7 3.3 7.6 8.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CENP-B_dimeris PF09026.10 ETO18620.1 - 1.9 8.9 9.0 6.1 7.3 9.0 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Myc_N PF01056.18 ETO18620.1 - 9.9 5.9 8.9 17 5.1 8.9 1.3 1 0 0 1 1 1 0 Myc amino-terminal region DUF4191 PF13829.6 ETO18622.1 - 0.69 9.2 1.8 0.66 9.3 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) Methyltransf_11 PF08241.12 ETO18623.1 - 1.1e-18 67.6 0.0 4.5e-17 62.5 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO18623.1 - 1.7e-17 63.9 0.1 2.9e-16 60.0 0.0 2.5 2 2 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO18623.1 - 1.2e-14 54.8 0.1 4.1e-14 53.1 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO18623.1 - 3.1e-10 40.1 0.1 1.7e-09 37.6 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO18623.1 - 1.1e-08 35.1 0.0 1.7e-08 34.5 0.0 1.4 1 1 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ETO18623.1 - 0.00069 19.3 0.1 0.001 18.7 0.1 1.2 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW CMAS PF02353.20 ETO18623.1 - 0.0024 17.2 0.7 0.015 14.6 0.0 1.9 1 1 1 2 2 2 1 Mycolic acid cyclopropane synthetase FtsJ PF01728.19 ETO18623.1 - 0.0036 17.4 0.6 0.021 15.0 0.0 2.5 2 1 0 2 2 2 1 FtsJ-like methyltransferase Methyltransf_9 PF08003.11 ETO18623.1 - 0.0051 15.8 0.1 0.0081 15.1 0.1 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 ETO18623.1 - 0.0064 16.0 0.0 0.0089 15.6 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 ETO18623.1 - 0.033 13.3 0.0 0.063 12.3 0.0 1.4 1 1 0 1 1 1 0 Ribosomal RNA adenine dimethylase TehB PF03848.14 ETO18623.1 - 0.047 13.1 0.1 0.068 12.6 0.1 1.3 1 0 0 1 1 1 0 Tellurite resistance protein TehB AdoMet_MTase PF07757.13 ETO18623.1 - 0.083 13.2 0.4 0.16 12.3 0.4 1.5 1 1 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase PrmA PF06325.13 ETO18623.1 - 0.14 11.5 0.0 0.24 10.7 0.0 1.5 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF4576 PF15144.6 ETO18623.1 - 0.17 11.8 0.0 0.33 10.9 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) DUF2722 PF10846.8 ETO18624.1 - 0.00023 20.3 45.0 0.0085 15.1 7.8 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2722) ESM4 PF15952.5 ETO18624.1 - 0.003 18.0 17.6 0.003 18.0 17.6 2.3 2 0 0 2 2 2 1 Enhancer of split M4 family Eapp_C PF10238.9 ETO18624.1 - 0.0036 17.4 8.8 0.0041 17.2 1.4 2.3 2 0 0 2 2 2 1 E2F-associated phosphoprotein OATP PF03137.20 ETO18624.1 - 0.004 15.5 2.0 0.004 15.5 2.0 1.9 2 0 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 ETO18624.1 - 0.0055 16.5 6.7 0.0055 16.5 6.7 2.2 2 0 0 2 2 2 1 Photosynthesis affected mutant 68 PepSY_TM PF03929.16 ETO18624.1 - 0.0094 15.7 1.4 0.0094 15.7 1.4 2.1 2 0 0 2 2 2 1 PepSY-associated TM region RLL PF10036.9 ETO18624.1 - 0.027 14.3 24.5 0.014 15.2 12.9 2.2 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein V_ATPase_I PF01496.19 ETO18624.1 - 0.058 11.3 14.4 0.0025 15.8 5.8 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family ABC2_membrane_2 PF12679.7 ETO18624.1 - 0.53 9.5 6.6 0.15 11.3 1.3 2.1 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF3439 PF11921.8 ETO18624.1 - 0.55 10.2 6.5 0.58 10.1 3.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) TERB2 PF15101.6 ETO18624.1 - 0.57 10.2 26.0 0.072 13.1 12.1 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4770 PF15994.5 ETO18624.1 - 0.59 10.4 23.9 0.32 11.2 11.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) Tim54 PF11711.8 ETO18624.1 - 0.79 8.4 12.8 0.048 12.4 2.9 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CRF1 PF10380.9 ETO18624.1 - 0.87 10.0 11.0 0.034 14.5 3.1 2.3 2 0 0 2 2 2 0 Transcription factor CRF1 ALMT PF11744.8 ETO18624.1 - 1.3 7.8 16.3 0.055 12.3 8.8 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter PNISR PF15996.5 ETO18624.1 - 1.3 9.3 20.5 0.72 10.1 10.3 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR CLN3 PF02487.17 ETO18624.1 - 1.3 8.0 11.4 0.065 12.3 3.4 2.2 2 0 0 2 2 2 0 CLN3 protein SpoIIP PF07454.11 ETO18624.1 - 1.9 7.9 19.6 0.28 10.6 9.9 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 ETO18624.1 - 2.1 8.0 9.0 0.44 10.2 2.9 2.2 2 0 0 2 2 2 0 FAM176 family RR_TM4-6 PF06459.12 ETO18624.1 - 2.2 8.1 16.3 0.082 12.7 6.4 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 ETO18624.1 - 2.3 7.1 31.5 0.018 14.1 15.4 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) XAP5 PF04921.14 ETO18624.1 - 2.4 7.9 11.7 0.4 10.5 5.1 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF4746 PF15928.5 ETO18624.1 - 4.1 6.7 9.7 0.58 9.5 2.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF1644 PF07800.12 ETO18624.1 - 4.2 7.4 11.3 4.2 7.4 5.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Peptidase_S15 PF02129.18 ETO18624.1 - 5.1 6.6 16.8 0.062 12.9 5.9 2.2 2 0 0 2 2 2 0 X-Pro dipeptidyl-peptidase (S15 family) Sec62 PF03839.16 ETO18624.1 - 5.2 6.5 11.4 1 8.8 5.0 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 FAM60A PF15396.6 ETO18624.1 - 5.6 6.9 13.0 0.98 9.4 6.2 2.1 2 0 0 2 2 2 0 Protein Family FAM60A CobT PF06213.12 ETO18624.1 - 5.9 6.2 27.0 0.16 11.4 11.8 2.2 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Rxt3 PF08642.10 ETO18624.1 - 7.9 7.3 11.7 0.77 10.5 3.0 2.5 2 0 0 2 2 2 0 Histone deacetylation protein Rxt3 DUF2072 PF09845.9 ETO18624.1 - 9 6.6 10.4 3.4 7.9 3.8 2.3 2 0 0 2 2 2 0 Zn-ribbon containing protein DUF1645 PF07816.11 ETO18624.1 - 9.6 6.7 9.2 5.1 7.6 1.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) MIF4G PF02854.19 ETO18625.1 - 1.9e-13 50.5 0.4 1.9e-13 50.5 0.4 2.4 2 1 1 3 3 3 1 MIF4G domain CNOT1_CAF1_bind PF16415.5 ETO18625.1 - 1.3e-05 24.7 0.1 2.8e-05 23.6 0.1 1.5 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain PAM2 PF07145.15 ETO18625.1 - 0.0001 21.8 2.3 0.00014 21.3 0.1 2.5 3 0 0 3 3 3 1 Ataxin-2 C-terminal region MIF4G PF02854.19 ETO18626.1 - 5.3e-08 32.8 2.2 1.4e-07 31.4 2.2 1.8 1 0 0 1 1 1 1 MIF4G domain rve PF00665.26 ETO18626.1 - 0.13 12.4 0.0 0.3 11.3 0.0 1.5 1 0 0 1 1 1 0 Integrase core domain TPT PF03151.16 ETO18627.1 - 3.9e-19 69.1 2.8 5.8e-19 68.5 2.8 1.3 1 0 0 1 1 1 1 Triose-phosphate Transporter family UAA PF08449.11 ETO18627.1 - 0.00015 21.1 2.7 0.00019 20.7 2.7 1.2 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO18627.1 - 0.047 13.9 10.7 0.58 10.3 10.7 2.1 1 1 0 1 1 1 0 EamA-like transporter family RunxI PF08504.11 ETO18627.1 - 0.39 11.5 2.0 10 6.9 0.0 2.8 2 1 1 3 3 3 0 Runx inhibition domain PRO8NT PF08082.11 ETO18630.1 - 2.1e-30 105.6 0.5 2.1e-30 105.6 0.5 1.5 2 0 0 2 2 2 1 PRO8NT (NUC069), PrP8 N-terminal domain PRO8NT PF08082.11 ETO18631.1 - 2.1e-29 102.4 2.4 3.7e-29 101.6 2.4 1.4 1 0 0 1 1 1 1 PRO8NT (NUC069), PrP8 N-terminal domain ABC_membrane PF00664.23 ETO18632.1 - 0.007 16.0 2.2 0.01 15.5 2.2 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region SRTM1 PF15872.5 ETO18632.1 - 0.017 15.3 1.2 0.027 14.6 1.2 1.4 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 vMSA PF00695.19 ETO18632.1 - 0.017 14.3 2.8 0.02 14.0 2.8 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus BatD PF13584.6 ETO18632.1 - 0.036 12.9 0.0 0.04 12.7 0.0 1.0 1 0 0 1 1 1 0 Oxygen tolerance Chromo_shadow PF01393.19 ETO18632.1 - 0.57 10.3 2.8 4.5 7.5 0.0 2.7 3 0 0 3 3 3 0 Chromo shadow domain DUF2207 PF09972.9 ETO18632.1 - 0.87 8.3 3.3 1.2 7.8 3.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SIT PF15330.6 ETO18632.1 - 1.1 9.7 5.2 2.3 8.7 5.2 1.4 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT Orf78 PF06024.12 ETO18632.1 - 4.3 7.7 7.9 6.5 7.1 7.9 1.5 1 1 0 1 1 1 0 Orf78 (ac78) RabGAP-TBC PF00566.18 ETO18633.1 - 3.4e-19 69.4 2.2 3.4e-19 69.4 2.2 2.2 2 0 0 2 2 2 2 Rab-GTPase-TBC domain FKBP_N PF01346.18 ETO18633.1 - 0.095 13.7 4.8 0.19 12.7 4.8 1.5 1 0 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PBP_sp32 PF07222.12 ETO18633.1 - 1 8.8 9.0 1.7 8.1 9.0 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 PAP_central PF04928.17 ETO18636.1 - 1.4e-34 119.2 0.8 1.6e-34 119.0 0.8 1.0 1 0 0 1 1 1 1 Poly(A) polymerase central domain Nrap_D2 PF17403.2 ETO18636.1 - 0.038 13.8 0.0 0.053 13.3 0.0 1.2 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Ank_2 PF12796.7 ETO18637.1 - 1.4e-07 32.0 0.0 3.1e-07 30.9 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO18637.1 - 0.00021 21.5 0.0 1.1 10.0 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETO18637.1 - 0.00026 21.5 0.0 1.2 9.8 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeats (many copies) CpXC PF14353.6 ETO18637.1 - 0.03 14.4 0.2 0.05 13.6 0.2 1.4 1 0 0 1 1 1 0 CpXC protein Fer4_9 PF13187.6 ETO18637.1 - 0.033 14.3 1.8 0.076 13.2 1.8 1.5 1 0 0 1 1 1 0 4Fe-4S dicluster domain Ank_5 PF13857.6 ETO18637.1 - 0.079 13.3 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 Ankyrin repeats (many copies) cNMP_binding PF00027.29 ETO18639.1 - 3.9e-17 62.1 0.0 5.6e-16 58.4 0.0 2.2 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Pkinase PF00069.25 ETO18639.1 - 3.1e-14 53.0 0.0 5e-14 52.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18639.1 - 1.4e-05 24.5 0.0 2.2e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1318 PF07027.12 ETO18639.1 - 0.18 12.3 1.0 18 5.9 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1318) Casc1 PF12366.8 ETO18639.1 - 0.6 9.6 3.2 4.4 6.7 0.0 2.1 2 0 0 2 2 2 0 Cancer susceptibility candidate 1 Pkinase PF00069.25 ETO18640.1 - 4.6e-17 62.3 0.1 2.8e-10 40.0 0.0 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18640.1 - 0.00039 19.8 0.0 0.043 13.1 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Ferrochelatase PF00762.19 ETO18641.1 - 0.00034 19.8 1.1 0.00042 19.5 1.1 1.1 1 0 0 1 1 1 1 Ferrochelatase Phospho_p8 PF10195.9 ETO18641.1 - 0.077 13.5 0.7 0.18 12.3 0.7 1.6 1 0 0 1 1 1 0 DNA-binding nuclear phosphoprotein p8 DEC-1_N PF04625.13 ETO18641.1 - 0.29 10.1 1.0 0.48 9.4 0.6 1.5 2 0 0 2 2 2 0 DEC-1 protein, N-terminal region IATP PF04568.12 ETO18645.1 - 0.016 15.6 0.6 0.033 14.6 0.6 1.5 1 0 0 1 1 1 0 Mitochondrial ATPase inhibitor, IATP CRM1_repeat_2 PF18784.1 ETO18648.1 - 2.7e-17 62.2 0.0 5.2e-17 61.2 0.0 1.5 1 0 0 1 1 1 1 CRM1 / Exportin repeat 2 CRM1_repeat_3 PF18787.1 ETO18648.1 - 9.1e-12 44.9 0.1 2.1e-11 43.8 0.1 1.6 1 0 0 1 1 1 1 CRM1 / Exportin repeat 3 CRM1_repeat PF18777.1 ETO18648.1 - 7.5e-08 31.7 0.0 1.3e-07 31.0 0.0 1.4 1 0 0 1 1 1 1 Chromosome region maintenance or exportin repeat TauE PF01925.19 ETO18649.1 - 4.7e-14 52.6 0.4 5.9e-14 52.3 0.4 1.0 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE DUF5313 PF17240.2 ETO18649.1 - 0.0082 16.6 0.1 0.012 16.0 0.1 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5313) DUF3169 PF11368.8 ETO18649.1 - 0.01 15.4 0.0 0.01 15.4 0.0 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) YbhQ PF11076.8 ETO18649.1 - 0.027 14.5 1.2 0.11 12.6 1.2 1.8 1 1 0 1 1 1 0 Putative inner membrane protein YbhQ Bax1-I PF01027.20 ETO18649.1 - 0.029 14.2 5.1 0.039 13.8 5.1 1.2 1 0 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 Adeno_E3B PF03376.14 ETO18649.1 - 0.15 12.3 0.2 0.39 11.0 0.0 1.8 2 0 0 2 2 2 0 Adenovirus E3B protein NADH-G_4Fe-4S_3 PF10588.9 ETO18649.1 - 0.19 11.3 6.9 0.44 10.1 0.1 2.5 2 0 0 2 2 2 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region DUF2956 PF11169.8 ETO18649.1 - 0.34 11.1 4.7 0.63 10.3 4.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) UPF0220 PF05255.11 ETO18649.1 - 0.58 9.7 2.4 0.65 9.5 1.1 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0220) Hexokinase_1 PF00349.21 ETO18650.1 - 5.5e-24 85.2 0.3 7.2e-24 84.8 0.3 1.1 1 0 0 1 1 1 1 Hexokinase Pkinase PF00069.25 ETO18651.1 - 3.1e-60 203.8 0.0 9.2e-59 199.0 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18651.1 - 1.8e-25 89.7 0.5 6.5e-24 84.6 0.4 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO18651.1 - 0.00024 20.5 0.0 0.00052 19.4 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO18651.1 - 0.037 13.3 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO18651.1 - 0.049 13.5 0.3 0.11 12.4 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family Acyl-ACP_TE PF01643.17 ETO18653.1 - 0.0041 16.4 0.2 0.0041 16.4 0.2 1.7 2 1 0 2 2 2 1 Acyl-ACP thioesterase Kelch_6 PF13964.6 ETO18654.1 - 0.00022 21.4 0.2 0.56 10.6 0.0 3.4 3 0 0 3 3 3 2 Kelch motif Leu_zip PF15294.6 ETO18655.1 - 8 5.9 28.3 0.78 9.2 8.4 2.7 2 1 1 3 3 3 0 Leucine zipper Acetate_kinase PF00871.17 ETO18656.1 - 0.35 9.5 3.1 0.37 9.4 3.1 1.0 1 0 0 1 1 1 0 Acetokinase family HEAT PF02985.22 ETO18657.1 - 1.5e-09 37.3 0.0 0.0023 18.1 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO18657.1 - 4.8e-09 36.5 0.0 0.00038 20.8 0.0 1.8 1 1 1 2 2 2 2 HEAT repeats Cnd1 PF12717.7 ETO18657.1 - 2.1e-05 24.6 1.7 0.0088 16.1 0.4 2.5 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 RTP1_C1 PF10363.9 ETO18657.1 - 0.00012 22.2 0.1 0.35 11.1 0.1 2.5 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO18657.1 - 0.0011 19.6 0.1 0.13 12.9 0.0 2.6 1 1 2 3 3 3 3 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO18657.1 - 0.0086 15.9 1.6 0.2 11.4 1.0 2.8 1 1 1 2 2 2 1 TATA-binding protein interacting (TIP20) PHD_like PF12910.7 ETO18657.1 - 0.062 13.3 2.4 3.5 7.7 0.6 2.5 1 1 2 3 3 3 0 Antitoxin of toxin-antitoxin, RelE / RelB, TA system MOR2-PAG1_C PF14225.6 ETO18657.1 - 0.12 12.2 0.5 0.69 9.7 0.5 2.1 1 1 0 1 1 1 0 Cell morphogenesis C-terminal NLE PF08154.12 ETO18657.1 - 0.14 12.7 0.7 3.7 8.2 0.0 2.7 2 1 1 3 3 3 0 NLE (NUC135) domain Fe-S_assembly PF04384.13 ETO18657.1 - 0.2 12.3 3.9 1.3 9.7 0.2 3.1 2 1 1 3 3 3 0 Iron-sulphur cluster assembly MSP7_C PF12948.7 ETO18657.1 - 0.26 12.0 8.0 5.5 7.7 1.6 3.1 2 2 2 4 4 4 0 MSP7-like protein C-terminal domain SAM_2 PF07647.17 ETO18658.1 - 4.6e-07 29.8 0.2 6.4e-07 29.4 0.2 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) BAF PF02961.14 ETO18658.1 - 0.0068 16.8 0.2 0.011 16.1 0.2 1.4 1 0 0 1 1 1 1 Barrier to autointegration factor ATPgrasp_ST PF14397.6 ETO18658.1 - 0.091 12.0 0.0 0.12 11.6 0.0 1.2 1 0 0 1 1 1 0 Sugar-transfer associated ATP-grasp WD40 PF00400.32 ETO18659.1 - 1.8e-64 212.1 18.7 1.1e-09 38.7 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18659.1 - 6.1e-21 74.5 4.6 9.4e-05 22.6 0.0 6.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO18659.1 - 1.8e-16 60.0 1.8 0.007 15.4 0.0 6.5 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO18659.1 - 3.2e-10 39.8 0.8 0.0008 18.8 0.1 3.3 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO18659.1 - 2.9e-06 26.2 7.3 0.53 8.9 0.6 4.9 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Frtz PF11768.8 ETO18659.1 - 1.8e-05 23.3 0.0 0.0047 15.3 0.0 2.4 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 ETO18659.1 - 9.9e-05 21.8 2.3 0.84 8.9 0.0 4.0 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO18659.1 - 0.00041 20.2 3.9 21 5.2 0.0 5.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO18659.1 - 0.0025 16.6 3.8 0.29 9.8 0.9 3.7 1 1 3 4 4 4 1 Nup133 N terminal like DUF5570 PF17731.1 ETO18659.1 - 0.0058 16.7 1.5 21 5.2 0.0 4.3 2 2 3 5 5 5 0 Family of unknown function (DUF5570) TolB_N PF04052.13 ETO18659.1 - 0.029 14.5 0.1 48 4.2 0.0 4.7 5 0 0 5 5 5 0 TolB amino-terminal domain Cadherin_4 PF17803.1 ETO18659.1 - 0.044 14.4 0.3 5.5 7.7 0.0 2.7 3 0 0 3 3 2 0 Bacterial cadherin-like domain Big_7 PF17957.1 ETO18659.1 - 0.061 14.1 3.3 44 4.9 0.0 4.3 5 1 0 5 5 5 0 Bacterial Ig domain PS_Dcarbxylase PF02666.15 ETO18659.1 - 0.074 12.6 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Phosphatidylserine decarboxylase PUF PF00806.19 ETO18660.1 - 4.5e-38 126.8 16.9 1.8e-06 27.3 0.3 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2457 PF10446.9 ETO18660.1 - 0.15 11.2 10.3 0.25 10.4 10.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO18660.1 - 1 7.5 7.1 2 6.5 7.1 1.4 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ETO18660.1 - 2.3 6.2 9.5 5.3 5.0 9.5 1.5 1 0 0 1 1 1 0 DNA polymerase phi Cpn60_TCP1 PF00118.24 ETO18661.1 - 1.4e-31 109.7 3.0 1.6e-31 109.5 3.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family SOG2 PF10428.9 ETO18662.1 - 0.015 14.5 9.1 0.015 14.5 9.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Apt1 PF10351.9 ETO18662.1 - 0.32 9.8 2.2 0.4 9.5 2.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ashwin PF15323.6 ETO18662.1 - 0.48 10.4 6.4 0.62 10.0 6.4 1.2 1 0 0 1 1 1 0 Developmental protein Med3 PF11593.8 ETO18662.1 - 4.4 6.4 21.4 7.7 5.6 21.4 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Macoilin PF09726.9 ETO18662.1 - 5.5 5.4 6.5 7.3 5.0 6.5 1.1 1 0 0 1 1 1 0 Macoilin family VSP PF03302.13 ETO18663.1 - 0.065 12.1 1.1 0.093 11.6 1.1 1.2 1 0 0 1 1 1 0 Giardia variant-specific surface protein WD40 PF00400.32 ETO18664.1 - 1.6e-34 117.4 28.3 6.7e-07 29.9 1.0 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18664.1 - 2.6e-12 46.9 2.1 0.036 14.4 0.0 5.9 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18664.1 - 5.7e-11 41.8 8.4 0.0011 17.8 0.1 5.8 3 1 2 6 6 6 5 Nucleoporin Nup120/160 WWE PF02825.20 ETO18667.1 - 6.8e-05 23.4 0.2 0.00014 22.4 0.2 1.5 1 0 0 1 1 1 1 WWE domain DUF678 PF05077.12 ETO18667.1 - 0.19 11.9 0.5 0.3 11.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF678) Cupin_8 PF13621.6 ETO18668.1 - 6.3e-22 78.5 0.3 1.1e-21 77.8 0.3 1.3 1 0 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ETO18668.1 - 4e-08 33.1 0.7 0.00051 19.6 0.1 2.4 2 1 0 2 2 2 2 Cupin superfamily protein JmjC PF02373.22 ETO18668.1 - 0.0029 18.0 1.0 0.016 15.6 0.7 2.4 1 1 0 1 1 1 1 JmjC domain, hydroxylase PAP1 PF08601.10 ETO18669.1 - 1.1 8.9 12.5 1.4 8.6 12.5 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Rep_fac-A_C PF08646.10 ETO18670.1 - 1e-11 44.8 2.6 2.2e-11 43.7 0.0 2.4 1 1 1 2 2 2 1 Replication factor-A C terminal domain Myc_target_1 PF15179.6 ETO18670.1 - 0.0083 16.0 8.0 0.0088 16.0 0.5 2.1 2 0 0 2 2 2 1 Myc target protein 1 Syntaxin-18_N PF10496.9 ETO18670.1 - 0.021 15.1 0.7 0.021 15.1 0.7 2.6 3 0 0 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus CPSF100_C PF13299.6 ETO18670.1 - 0.034 14.3 0.3 0.064 13.4 0.3 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Spt20 PF12090.8 ETO18670.1 - 1 8.9 15.1 0.067 12.8 8.0 2.0 2 0 0 2 2 2 0 Spt20 family Zip PF02535.22 ETO18671.1 - 0.028 13.7 0.3 0.028 13.7 0.3 2.4 3 0 0 3 3 3 0 ZIP Zinc transporter TLD PF07534.16 ETO18672.1 - 5e-27 94.8 0.2 1.5e-26 93.3 0.2 1.9 1 0 0 1 1 1 1 TLD UPF0242 PF06785.11 ETO18672.1 - 0.00013 22.2 16.9 0.00013 22.2 16.9 3.8 2 1 0 3 3 3 1 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 ETO18672.1 - 0.0041 17.2 24.3 0.0041 17.2 24.3 4.6 2 1 2 4 4 4 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF3446 PF11928.8 ETO18672.1 - 0.0071 16.6 33.1 0.023 15.0 6.9 3.4 3 0 0 3 3 3 2 Early growth response N-terminal domain YabA PF06156.13 ETO18672.1 - 0.013 16.1 9.8 0.013 16.1 9.8 5.6 2 2 2 4 4 4 0 Initiation control protein YabA DUF1664 PF07889.12 ETO18672.1 - 0.17 11.9 32.8 0.15 12.1 7.2 4.5 2 2 2 4 4 4 0 Protein of unknown function (DUF1664) WD40 PF00400.32 ETO18673.1 - 2.3e-11 44.1 13.3 0.00061 20.5 0.3 5.3 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18673.1 - 0.00014 22.1 0.6 5.5 7.4 0.0 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Laminin_G_3 PF13385.6 ETO18674.1 - 0.00053 20.2 0.1 0.0048 17.1 0.0 2.4 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily DUF1981 PF09324.10 ETO18674.1 - 0.014 15.2 0.4 5.4 6.9 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1981) TolA_bind_tri PF16331.5 ETO18675.1 - 1.1 9.4 12.2 2.2 8.4 2.7 2.5 2 1 0 2 2 2 0 TolA binding protein trimerisation SlyX PF04102.12 ETO18675.1 - 9.5 6.9 7.5 2.1 9.0 1.5 2.4 2 1 0 2 2 2 0 SlyX DFP PF04127.15 ETO18676.1 - 1.1 9.0 5.9 1.3 8.9 5.9 1.0 1 0 0 1 1 1 0 DNA / pantothenate metabolism flavoprotein BP28CT PF08146.12 ETO18680.1 - 0.1 12.4 3.3 0.15 11.9 0.3 2.0 1 1 1 2 2 2 0 BP28CT (NUC211) domain Pkinase PF00069.25 ETO18681.1 - 7.3e-08 32.1 0.0 8.2e-08 31.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO18682.1 - 1.2e-41 142.8 0.1 1.6e-41 142.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18682.1 - 6.5e-18 64.9 0.0 8.1e-18 64.6 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO18682.1 - 2.7e-05 24.2 0.0 3.3e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO18682.1 - 0.00045 19.6 0.0 0.00059 19.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO18682.1 - 0.0058 15.4 0.0 0.0065 15.3 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 ETO18682.1 - 0.0064 16.1 0.0 0.0087 15.7 0.0 1.3 1 0 0 1 1 1 1 Choline/ethanolamine kinase FTA2 PF13095.6 ETO18682.1 - 0.014 15.1 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Pox_ser-thr_kin PF05445.11 ETO18682.1 - 0.044 12.8 0.0 0.068 12.1 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 ETO18682.1 - 0.072 12.4 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO18682.1 - 0.15 11.0 0.2 0.25 10.3 0.2 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Kelch_1 PF01344.25 ETO18683.1 - 0.023 14.2 0.1 4.9 6.8 0.0 2.7 2 0 0 2 2 2 0 Kelch motif Peptidase_M13_N PF05649.13 ETO18684.1 - 3.2e-06 27.1 0.5 9.9e-06 25.5 0.5 1.6 1 1 0 1 1 1 1 Peptidase family M13 Peptidase_M13_N PF05649.13 ETO18685.1 - 0.013 15.2 0.0 0.026 14.2 0.0 1.4 1 0 0 1 1 1 0 Peptidase family M13 DUF2052 PF09747.9 ETO18686.1 - 0.4 10.8 15.6 0.64 10.1 8.9 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) GREB1 PF15782.5 ETO18686.1 - 0.8 6.8 10.8 0.92 6.5 10.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Gastrin PF00918.17 ETO18686.1 - 4.1 8.4 7.2 0.3 12.0 1.7 2.0 2 0 0 2 2 2 0 Gastrin/cholecystokinin family TRAP_alpha PF03896.16 ETO18686.1 - 8.1 5.6 9.0 1.4 8.0 5.4 1.5 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit UPF0302 PF08864.10 ETO18687.1 - 0.011 15.7 1.7 0.023 14.8 1.7 1.5 1 0 0 1 1 1 0 UPF0302 domain BSP_II PF05432.11 ETO18687.1 - 0.017 14.9 20.6 0.021 14.6 20.6 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Menin PF05053.13 ETO18687.1 - 2.5 6.3 17.5 3.2 6.0 17.5 1.0 1 0 0 1 1 1 0 Menin DUF913 PF06025.12 ETO18687.1 - 3.6 6.5 9.1 5.7 5.8 9.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 ETO18687.1 - 3.7 7.5 9.2 5.3 7.0 9.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Raftlin PF15250.6 ETO18687.1 - 4 6.1 14.7 5 5.8 14.7 1.1 1 0 0 1 1 1 0 Raftlin Pox_Ag35 PF03286.14 ETO18687.1 - 5.4 6.7 23.5 8.5 6.1 23.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein ALMT PF11744.8 ETO18687.1 - 6.3 5.5 14.3 9.7 4.9 14.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Nop53 PF07767.11 ETO18687.1 - 6.9 5.9 34.2 10 5.4 34.2 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) NPR3 PF03666.13 ETO18687.1 - 9.8 4.8 26.3 12 4.5 26.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Helicase_PWI PF18149.1 ETO18688.1 - 3e-11 43.5 0.1 5.9e-11 42.5 0.1 1.5 1 0 0 1 1 1 1 N-terminal helicase PWI domain YL1 PF05764.13 ETO18688.1 - 0.025 14.7 10.7 0.036 14.2 10.7 1.2 1 0 0 1 1 1 0 YL1 nuclear protein SMN PF06003.12 ETO18688.1 - 3.3 6.9 10.9 0.15 11.3 2.7 2.0 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) Sec63 PF02889.16 ETO18689.1 - 2e-119 397.5 8.6 1.8e-83 279.7 1.1 2.3 2 0 0 2 2 2 2 Sec63 Brl domain DEAD PF00270.29 ETO18689.1 - 1.3e-40 139.0 0.0 2.1e-24 86.2 0.1 2.8 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 ETO18689.1 - 9.7e-17 61.5 0.0 4.3e-12 46.4 0.0 3.0 3 0 0 3 3 3 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO18689.1 - 1.2e-08 35.2 0.1 1.1e-05 25.7 0.0 5.0 3 2 1 4 4 4 1 Helicase conserved C-terminal domain Helicase_PWI PF18149.1 ETO18689.1 - 3.3e-08 33.7 0.3 1.3e-07 31.8 0.3 2.1 1 0 0 1 1 1 1 N-terminal helicase PWI domain AAA_22 PF13401.6 ETO18689.1 - 0.013 15.8 0.6 0.14 12.4 0.0 3.1 3 1 0 3 3 3 0 AAA domain RhlB PF12300.8 ETO18689.1 - 0.034 14.3 3.3 0.059 13.5 3.3 1.3 1 0 0 1 1 1 0 ATP-dependent RNA helicase RhlB NuiA PF07924.11 ETO18689.1 - 0.044 14.2 0.0 0.16 12.4 0.0 1.9 1 0 0 1 1 1 0 Nuclease A inhibitor-like protein Pkinase PF00069.25 ETO18690.1 - 1.1e-06 28.2 0.2 2.1e-06 27.3 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain BSP_II PF05432.11 ETO18690.1 - 0.22 11.2 7.1 0.34 10.6 7.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Pkinase PF00069.25 ETO18691.1 - 4.6e-47 160.6 0.4 2.9e-46 158.0 0.4 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18691.1 - 7.6e-19 68.0 0.5 1.8e-18 66.8 0.5 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 ETO18691.1 - 4.4e-12 46.3 4.1 6.8e-11 42.5 1.3 2.8 2 1 0 2 2 2 1 Regulator of G protein signaling domain Haspin_kinase PF12330.8 ETO18691.1 - 0.0041 16.1 0.1 0.0075 15.2 0.1 1.4 1 0 0 1 1 1 1 Haspin like kinase domain SAC3 PF12209.8 ETO18691.1 - 0.47 10.7 2.8 0.46 10.7 0.2 2.4 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain Abhydrolase_6 PF12697.7 ETO18693.1 - 6.8e-06 26.8 0.0 8.1e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETO18693.1 - 9.3e-06 25.5 0.0 1.1e-05 25.2 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF676 PF05057.14 ETO18693.1 - 0.0058 16.2 0.0 0.008 15.7 0.0 1.2 1 0 0 1 1 1 1 Putative serine esterase (DUF676) LIDHydrolase PF10230.9 ETO18693.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.3 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase GSIII_N PF12437.8 ETO18694.1 - 0.023 14.4 0.0 0.035 13.8 0.0 1.3 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal NAD_binding_8 PF13450.6 ETO18695.1 - 2.1e-05 24.7 0.0 3.8e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Mqo PF06039.15 ETO18695.1 - 0.0044 15.6 0.3 0.0057 15.3 0.3 1.1 1 0 0 1 1 1 1 Malate:quinone oxidoreductase (Mqo) tRNA_SAD PF07973.14 ETO18696.1 - 2.8e-15 56.1 0.1 4.1e-15 55.6 0.1 1.3 1 0 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain tRNA-synt_2c PF01411.19 ETO18697.1 - 4e-202 672.6 0.9 5.8e-202 672.1 0.9 1.2 1 0 0 1 1 1 1 tRNA synthetases class II (A) Rad10 PF03834.14 ETO18698.1 - 2.4e-23 82.3 0.1 3.5e-23 81.8 0.1 1.2 1 0 0 1 1 1 1 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HHH_2 PF12826.7 ETO18699.1 - 4.7e-08 33.0 0.0 9.2e-08 32.1 0.0 1.5 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_5 PF14520.6 ETO18699.1 - 3.8e-07 30.6 0.0 5.7e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 Helix-hairpin-helix domain HHH PF00633.23 ETO18699.1 - 0.00047 19.9 0.1 0.00078 19.2 0.1 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif HHH_3 PF12836.7 ETO18699.1 - 0.013 15.8 0.2 0.027 14.7 0.2 1.5 1 0 0 1 1 1 0 Helix-hairpin-helix motif tRNA_edit PF04073.15 ETO18699.1 - 0.11 12.5 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Aminoacyl-tRNA editing domain Rad10 PF03834.14 ETO18699.1 - 0.17 11.9 0.2 0.36 10.8 0.1 1.6 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) HrpB7 PF09486.10 ETO18700.1 - 0.0088 16.4 0.0 0.013 15.9 0.0 1.3 1 0 0 1 1 1 1 Bacterial type III secretion protein (HrpB7) DUF3450 PF11932.8 ETO18700.1 - 0.01 15.1 0.1 0.015 14.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Sas10_Utp3 PF04000.15 ETO18700.1 - 0.25 12.0 2.5 0.44 11.2 0.3 2.1 2 0 0 2 2 2 0 Sas10/Utp3/C1D family FHIPEP PF00771.20 ETO18701.1 - 0.027 12.9 0.0 0.039 12.4 0.0 1.1 1 0 0 1 1 1 0 FHIPEP family PIF3 PF05006.12 ETO18701.1 - 0.044 13.9 0.2 0.099 12.7 0.1 1.7 1 1 0 1 1 1 0 Per os infectivity factor 3 GCK PF07802.11 ETO18701.1 - 0.088 13.2 1.5 0.87 10.1 0.2 2.4 2 0 0 2 2 2 0 GCK domain AAA_5 PF07728.14 ETO18702.1 - 6.8e-05 22.9 0.0 0.00011 22.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) WD40 PF00400.32 ETO18703.1 - 9.1e-11 42.1 4.8 0.0027 18.5 0.2 3.7 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO18703.1 - 0.017 13.8 1.1 0.1 11.2 0.8 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Nab6_mRNP_bdg PF10567.9 ETO18704.1 - 0.0011 18.6 9.2 0.0014 18.2 9.2 1.0 1 0 0 1 1 1 1 RNA-recognition motif CPSF100_C PF13299.6 ETO18704.1 - 0.039 14.1 6.1 0.046 13.9 6.1 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Mcm10 PF09332.11 ETO18704.1 - 0.1 12.0 13.9 0.12 11.8 13.9 1.0 1 0 0 1 1 1 0 Mcm10 replication factor FAM60A PF15396.6 ETO18704.1 - 0.15 12.1 10.7 0.17 11.8 10.7 1.0 1 0 0 1 1 1 0 Protein Family FAM60A RNA_pol_Rpc4 PF05132.14 ETO18704.1 - 0.19 12.2 5.8 0.2 12.1 5.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 NPR3 PF03666.13 ETO18704.1 - 0.2 10.4 8.5 0.21 10.3 8.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Striatin PF08232.12 ETO18704.1 - 0.21 12.2 10.1 0.27 11.8 10.1 1.1 1 0 0 1 1 1 0 Striatin family Ctr PF04145.15 ETO18704.1 - 0.32 11.6 2.3 0.37 11.4 2.3 1.1 1 0 0 1 1 1 0 Ctr copper transporter family Zip PF02535.22 ETO18704.1 - 0.42 9.8 4.4 0.43 9.8 4.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter NST1 PF13945.6 ETO18704.1 - 0.47 10.5 17.5 0.65 10.1 17.5 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator ATP11 PF06644.11 ETO18704.1 - 0.48 10.2 8.2 0.53 10.0 8.2 1.1 1 0 0 1 1 1 0 ATP11 protein Rtf2 PF04641.12 ETO18704.1 - 0.61 9.4 15.7 0.71 9.2 15.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger MAJIN PF15077.6 ETO18704.1 - 0.86 9.3 7.1 0.97 9.2 7.1 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein Presenilin PF01080.17 ETO18704.1 - 1 8.0 7.5 1.1 8.0 7.5 1.0 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 ETO18704.1 - 1.3 8.7 6.4 1.8 8.3 6.4 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 HCO3_cotransp PF00955.21 ETO18704.1 - 1.4 7.6 4.0 1.6 7.4 4.0 1.0 1 0 0 1 1 1 0 HCO3- transporter family Connexin PF00029.19 ETO18704.1 - 2.1 8.0 3.8 2.2 8.0 3.8 1.1 1 0 0 1 1 1 0 Connexin DUF4834 PF16118.5 ETO18704.1 - 2.1 9.3 6.4 2.8 8.9 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CLN3 PF02487.17 ETO18704.1 - 3.5 6.6 4.1 3.5 6.6 4.1 1.0 1 0 0 1 1 1 0 CLN3 protein E2F_TDP PF02319.20 ETO18706.1 - 0.059 13.4 0.2 0.73 9.9 0.0 2.8 2 0 0 2 2 2 0 E2F/DP family winged-helix DNA-binding domain Baculo_PEP_C PF04513.12 ETO18706.1 - 1.2 9.2 7.3 0.1 12.6 1.5 2.2 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus 4PPT_N PF17837.1 ETO18707.1 - 0.058 13.5 0.0 0.088 12.9 0.0 1.2 1 0 0 1 1 1 0 4'-phosphopantetheinyl transferase N-terminal domain SPT16 PF08644.11 ETO18708.1 - 0.018 15.2 0.6 0.018 15.2 0.6 1.7 2 0 0 2 2 2 0 FACT complex subunit (SPT16/CDC68) Kinesin PF00225.23 ETO18710.1 - 4.1e-39 134.4 0.0 7.3e-39 133.6 0.0 1.3 1 1 0 1 1 1 1 Kinesin motor domain PI3_PI4_kinase PF00454.27 ETO18711.1 - 2.1e-28 99.8 6.4 1.8e-16 60.7 0.7 3.2 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase DUF3474 PF11960.8 ETO18713.1 - 0.11 12.7 2.7 0.14 12.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) DUF1461 PF07314.11 ETO18713.1 - 3.6 7.5 4.3 25 4.7 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1461) RasGEF PF00617.19 ETO18714.1 - 4e-40 137.9 0.4 9.6e-40 136.7 0.1 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ETO18714.1 - 2.1e-12 47.2 2.0 4.3e-12 46.2 0.1 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif Siah-Interact_N PF09032.11 ETO18714.1 - 0.093 13.1 10.2 0.46 10.8 1.0 2.9 2 0 0 2 2 2 0 Siah interacting protein, N terminal Spt20 PF12090.8 ETO18714.1 - 0.31 10.6 14.3 0.037 13.6 3.6 2.5 2 0 0 2 2 2 0 Spt20 family DUF4834 PF16118.5 ETO18714.1 - 3 8.9 9.6 0.67 11.0 2.4 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Esterase_phd PF10503.9 ETO18715.1 - 0.00083 18.9 0.8 0.0018 17.8 0.4 1.8 2 1 0 2 2 2 1 Esterase PHB depolymerase Lipocalin_7 PF14651.6 ETO18716.1 - 0.0077 16.2 0.7 0.021 14.7 0.7 1.9 1 1 0 1 1 1 1 Lipocalin / cytosolic fatty-acid binding protein family Thaumatin PF00314.17 ETO18717.1 - 2.9e-21 76.1 10.8 4.9e-13 49.2 1.8 5.3 3 2 0 4 4 4 2 Thaumatin family SAP PF02037.27 ETO18718.1 - 6.2e-09 35.4 0.1 1.9e-08 33.8 0.1 1.9 1 0 0 1 1 1 1 SAP domain WGR PF05406.15 ETO18718.1 - 4.6e-08 33.0 0.0 4.6e-08 33.0 0.0 2.9 3 0 0 3 3 1 1 WGR domain RR_TM4-6 PF06459.12 ETO18718.1 - 0.077 12.8 28.8 0.52 10.1 13.8 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 AAA_23 PF13476.6 ETO18718.1 - 0.12 12.8 22.9 0.63 10.5 1.6 2.3 2 0 0 2 2 2 0 AAA domain CPSF100_C PF13299.6 ETO18718.1 - 0.25 11.5 18.6 0.37 10.9 1.1 3.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DDHD PF02862.17 ETO18718.1 - 0.79 9.8 11.1 1.2 9.2 2.2 2.4 2 1 0 2 2 2 0 DDHD domain Presenilin PF01080.17 ETO18718.1 - 0.82 8.4 11.9 0.57 8.9 1.3 2.2 2 0 0 2 2 2 0 Presenilin MecA PF05389.12 ETO18718.1 - 1.4 8.5 16.0 0.99 9.0 0.8 2.5 2 1 0 2 2 2 0 Negative regulator of genetic competence (MecA) Folate_carrier PF01770.18 ETO18718.1 - 2 7.0 7.7 3.2 6.4 1.2 2.2 2 0 0 2 2 2 0 Reduced folate carrier Tim54 PF11711.8 ETO18718.1 - 2.1 7.0 21.0 0.088 11.6 2.6 2.6 3 0 0 3 3 3 0 Inner membrane protein import complex subunit Tim54 DUF2052 PF09747.9 ETO18718.1 - 2.3 8.3 27.3 0.61 10.2 6.4 3.0 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.15 ETO18718.1 - 3.3 6.4 13.5 2.6 6.7 5.7 2.1 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein Eapp_C PF10238.9 ETO18718.1 - 4.6 7.3 17.2 0.78 9.8 0.2 3.1 3 0 0 3 3 3 0 E2F-associated phosphoprotein Connexin PF00029.19 ETO18718.1 - 4.7 6.9 21.3 0.27 11.0 2.2 2.8 3 0 0 3 3 3 0 Connexin Hid1 PF12722.7 ETO18718.1 - 6.3 4.8 10.8 4.2 5.4 1.0 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein zf_CCCH_4 PF18345.1 ETO18719.1 - 0.015 15.4 0.6 0.015 15.4 0.6 2.8 2 0 0 2 2 2 0 Zinc finger domain zf-CCCH_4 PF18044.1 ETO18719.1 - 0.032 14.0 10.6 0.12 12.2 0.1 2.9 2 0 0 2 2 2 0 CCCH-type zinc finger WD40 PF00400.32 ETO18720.1 - 4.7e-18 65.2 4.0 3e-09 37.3 0.6 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18720.1 - 3.7e-07 30.3 0.2 0.00077 19.7 0.0 2.1 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO18720.1 - 0.0091 15.9 0.0 0.18 11.6 0.0 2.0 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETO18720.1 - 0.035 12.9 0.0 0.16 10.6 0.1 1.8 1 1 1 2 2 2 0 Nup133 N terminal like V-ATPase_G PF03179.15 ETO18721.1 - 4.4e-13 49.7 13.5 5.4e-13 49.4 13.5 1.1 1 0 0 1 1 1 1 Vacuolar (H+)-ATPase G subunit Filament PF00038.21 ETO18721.1 - 0.007 16.0 11.1 0.0078 15.8 11.1 1.1 1 0 0 1 1 1 1 Intermediate filament protein DUF3584 PF12128.8 ETO18721.1 - 0.015 12.8 11.3 0.017 12.7 11.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) FRD2 PF03197.13 ETO18721.1 - 0.029 14.6 2.0 0.04 14.2 2.0 1.3 1 1 0 1 1 1 0 Bacteriophage FRD2 protein PYRIN PF02758.16 ETO18721.1 - 0.03 14.5 2.3 0.055 13.6 2.3 1.5 1 0 0 1 1 1 0 PAAD/DAPIN/Pyrin domain V-ATPase_G_2 PF16999.5 ETO18721.1 - 0.081 13.3 7.0 0.44 11.0 3.5 2.1 1 1 1 2 2 2 0 Vacuolar (H+)-ATPase G subunit UCMA PF17085.5 ETO18721.1 - 0.12 12.4 6.1 0.16 12.0 6.1 1.2 1 0 0 1 1 1 0 Unique cartilage matrix associated protein ATP-synt_B PF00430.18 ETO18721.1 - 0.19 11.9 9.3 1.3 9.1 4.7 2.1 1 1 1 2 2 2 0 ATP synthase B/B' CF(0) SOGA PF11365.8 ETO18721.1 - 0.29 12.3 12.0 0.14 13.3 7.3 2.0 1 1 1 2 2 2 0 Protein SOGA V_ATPase_I PF01496.19 ETO18721.1 - 0.32 8.9 7.1 0.32 8.9 7.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tropomyosin_1 PF12718.7 ETO18721.1 - 0.69 10.1 19.2 1 9.5 19.2 1.3 1 1 0 1 1 1 0 Tropomyosin like Atg14 PF10186.9 ETO18721.1 - 0.79 8.7 8.1 0.88 8.6 8.1 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1043 PF06295.12 ETO18721.1 - 0.87 9.6 8.7 0.94 9.5 8.1 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) DUF4407 PF14362.6 ETO18721.1 - 0.9 8.8 6.6 1 8.6 6.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2203 PF09969.9 ETO18721.1 - 1.5 9.6 7.7 2.7 8.7 7.7 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Seryl_tRNA_N PF02403.22 ETO18721.1 - 1.6 9.0 16.1 1.2 9.4 1.2 2.7 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain TINF2_N PF14973.6 ETO18721.1 - 2.1 8.7 7.8 1 9.7 3.3 2.0 1 1 1 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus Tho2 PF11262.8 ETO18721.1 - 2.3 7.4 11.3 2.7 7.1 11.3 1.1 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 LMBR1 PF04791.16 ETO18721.1 - 2.3 7.0 7.6 2.6 6.8 7.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3552 PF12072.8 ETO18721.1 - 2.5 7.5 19.0 13 5.1 19.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3552) TMPIT PF07851.13 ETO18721.1 - 3.6 6.7 11.2 4.3 6.5 11.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein Fib_alpha PF08702.10 ETO18721.1 - 4.6 7.4 12.4 10 6.3 12.4 1.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family PCRF PF03462.18 ETO18721.1 - 8.5 6.2 11.1 16 5.3 11.1 1.5 1 1 0 1 1 1 0 PCRF domain HutD PF05962.11 ETO18722.1 - 1.1e-42 146.0 0.0 1.4e-42 145.8 0.0 1.0 1 0 0 1 1 1 1 HutD CSG2 PF16965.5 ETO18723.1 - 1.6 7.6 13.3 0.14 11.1 8.6 1.5 2 0 0 2 2 2 0 Ceramide synthase regulator MAGI_u1 PF16663.5 ETO18724.1 - 0.061 13.4 1.1 0.061 13.4 1.1 2.8 3 1 1 4 4 4 0 Unstructured region on MAGI Methyltransf_12 PF08242.12 ETO18724.1 - 2.6 8.8 4.7 1.8 9.3 2.3 1.8 1 1 0 2 2 2 0 Methyltransferase domain Exo_endo_phos PF03372.23 ETO18725.1 - 0.0052 16.3 0.1 0.0084 15.6 0.1 1.3 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FAM60A PF15396.6 ETO18726.1 - 0.029 14.4 5.3 0.035 14.1 5.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ETO18726.1 - 0.049 12.4 10.2 0.064 12.0 10.2 1.2 1 0 0 1 1 1 0 Presenilin Dsh_C PF12316.8 ETO18726.1 - 0.27 11.6 6.2 0.35 11.2 6.2 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal MAJIN PF15077.6 ETO18726.1 - 6.3 6.5 6.7 8.2 6.1 6.7 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein VPS9 PF02204.18 ETO18729.1 - 7e-14 51.9 0.2 9.4e-14 51.5 0.2 1.2 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PRESAN PF09687.10 ETO18729.1 - 0.032 14.8 0.1 0.055 14.0 0.1 1.4 1 0 0 1 1 1 0 Plasmodium RESA N-terminal HEAT PF02985.22 ETO18730.1 - 1e-08 34.7 0.1 0.00066 19.7 0.0 4.6 5 0 0 5 5 5 2 HEAT repeat Cnd1 PF12717.7 ETO18730.1 - 5.6e-08 33.0 2.1 0.0047 17.0 0.1 3.1 1 1 2 3 3 3 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO18730.1 - 9.6e-08 32.4 0.0 0.09 13.3 0.0 3.4 3 0 0 3 3 3 2 HEAT-like repeat HEAT_2 PF13646.6 ETO18730.1 - 6.3e-06 26.5 0.0 0.007 16.7 0.0 2.7 3 0 0 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO18730.1 - 0.00012 22.6 1.1 1.3 9.7 0.0 4.0 2 2 2 4 4 4 1 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO18730.1 - 0.00032 20.5 2.8 2 8.2 0.1 3.4 2 1 1 4 4 4 2 TATA-binding protein interacting (TIP20) Adaptin_N PF01602.20 ETO18730.1 - 0.00038 19.1 1.7 0.14 10.6 0.0 2.1 1 1 0 2 2 2 2 Adaptin N terminal region Med23 PF11573.8 ETO18730.1 - 0.00062 17.6 0.2 0.092 10.4 0.1 2.3 2 1 0 2 2 2 2 Mediator complex subunit 23 ThylakoidFormat PF11264.8 ETO18730.1 - 0.0023 17.7 0.1 1.1 8.9 0.2 2.5 2 1 1 3 3 3 2 Thylakoid formation protein Dopey_N PF04118.14 ETO18730.1 - 0.052 12.7 1.1 3.7 6.6 0.7 3.0 1 1 1 2 2 2 0 Dopey, N-terminal MnmE_helical PF12631.7 ETO18730.1 - 0.055 13.6 0.2 0.47 10.6 0.0 2.1 2 0 0 2 2 2 0 MnmE helical domain CLASP_N PF12348.8 ETO18730.1 - 0.081 12.5 1.3 12 5.4 0.4 3.1 2 1 0 2 2 2 0 CLASP N terminal SirA PF10747.9 ETO18730.1 - 0.11 12.8 1.5 12 6.2 0.1 2.6 1 1 2 3 3 3 0 Sporulation inhibitor of replication protein SirA ATPase PF06745.13 ETO18730.1 - 0.12 11.7 0.2 0.95 8.8 0.0 2.0 2 0 0 2 2 2 0 KaiC DUF3990 PF13151.6 ETO18732.1 - 0.03 14.0 0.0 0.068 12.9 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3990) Herpes_UL24 PF01646.16 ETO18734.1 - 0.068 13.1 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Herpes virus proteins UL24 and UL76 Serinc PF03348.15 ETO18735.1 - 0.023 13.6 0.1 0.029 13.3 0.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Connexin PF00029.19 ETO18736.1 - 0.015 15.1 6.9 0.018 14.8 6.9 1.0 1 0 0 1 1 1 0 Connexin CPSF100_C PF13299.6 ETO18736.1 - 0.045 13.9 6.8 0.048 13.8 6.8 1.0 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4770 PF15994.5 ETO18736.1 - 0.085 13.1 6.7 0.1 12.9 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) SpoIIP PF07454.11 ETO18736.1 - 0.11 11.9 9.6 0.13 11.8 9.6 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) SR-25 PF10500.9 ETO18736.1 - 0.16 11.5 20.1 0.29 10.7 20.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RR_TM4-6 PF06459.12 ETO18736.1 - 0.2 11.4 14.2 0.24 11.2 14.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peptidase_U57 PF05582.12 ETO18736.1 - 0.39 9.9 7.4 0.46 9.7 7.4 1.0 1 0 0 1 1 1 0 YabG peptidase U57 AIF_C PF14721.6 ETO18736.1 - 0.46 10.8 6.9 0.55 10.6 6.9 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PPL5 PF18168.1 ETO18736.1 - 0.79 9.0 8.6 0.83 8.9 8.6 1.0 1 0 0 1 1 1 0 Prim-pol family 5 Presenilin PF01080.17 ETO18736.1 - 0.81 8.4 8.3 0.98 8.1 8.3 1.0 1 0 0 1 1 1 0 Presenilin Peroxin-13_N PF04088.13 ETO18736.1 - 0.92 9.8 4.1 1 9.6 4.1 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Agouti PF05039.12 ETO18736.1 - 0.96 10.2 6.9 1.2 9.9 6.9 1.1 1 0 0 1 1 1 0 Agouti protein EIIBC-GUT_N PF03612.14 ETO18736.1 - 0.99 9.1 10.1 1.2 8.9 10.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4637 PF15470.6 ETO18736.1 - 1.1 9.0 9.5 1.3 8.8 9.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) OATP PF03137.20 ETO18736.1 - 1.1 7.5 3.0 1 7.6 3.0 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Vfa1 PF08432.10 ETO18736.1 - 1.1 9.5 21.2 1.3 9.3 21.2 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 EOS1 PF12326.8 ETO18736.1 - 1.2 9.0 5.5 1.4 8.8 5.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein CLN3 PF02487.17 ETO18736.1 - 1.6 7.7 4.6 1.5 7.7 4.6 1.0 1 0 0 1 1 1 0 CLN3 protein DNApol_Exo PF18136.1 ETO18736.1 - 1.6 7.8 9.3 1.8 7.6 9.3 1.1 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain Sugar_tr PF00083.24 ETO18736.1 - 1.6 7.5 3.0 1.5 7.6 3.0 1.0 1 0 0 1 1 1 0 Sugar (and other) transporter Eapp_C PF10238.9 ETO18736.1 - 1.6 8.8 12.1 2.2 8.4 12.1 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein GAGA_bind PF06217.12 ETO18736.1 - 1.6 8.9 13.6 1.8 8.8 13.6 1.0 1 0 0 1 1 1 0 GAGA binding protein-like family YqfQ PF14181.6 ETO18736.1 - 1.7 8.8 13.4 1.9 8.6 13.4 1.0 1 0 0 1 1 1 0 YqfQ-like protein DUF3807 PF12720.7 ETO18736.1 - 1.8 8.8 15.1 2 8.6 15.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) CSG2 PF16965.5 ETO18736.1 - 2.2 7.1 4.9 2.6 6.9 4.9 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator O-antigen_lig PF13425.6 ETO18736.1 - 2.3 6.9 8.0 2.6 6.7 8.0 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Folate_carrier PF01770.18 ETO18736.1 - 2.5 6.8 4.7 2.4 6.8 4.7 1.1 1 0 0 1 1 1 0 Reduced folate carrier RNA_pol_Rpc4 PF05132.14 ETO18736.1 - 2.5 8.5 12.8 2.9 8.3 12.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETO18736.1 - 3.7 5.7 11.5 4.1 5.6 11.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Tim54 PF11711.8 ETO18736.1 - 4.1 6.1 13.2 4.6 5.9 13.2 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO18736.1 - 4.1 6.5 7.4 4.7 6.3 7.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Ureide_permease PF07168.11 ETO18736.1 - 4.2 6.0 6.4 4.2 6.0 6.4 1.0 1 0 0 1 1 1 0 Ureide permease FAM176 PF14851.6 ETO18736.1 - 4.8 6.8 7.2 5.6 6.6 7.2 1.1 1 0 0 1 1 1 0 FAM176 family Atrophin-1 PF03154.15 ETO18736.1 - 5.5 5.1 8.0 5.7 5.1 8.0 1.0 1 0 0 1 1 1 0 Atrophin-1 family Borrelia_P83 PF05262.11 ETO18736.1 - 6.3 5.2 18.2 7.6 4.9 18.2 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein GNAT_acetyltr_2 PF13718.6 ETO18736.1 - 7 6.0 8.1 7.9 5.8 8.1 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 MTHFR PF02219.17 ETO18737.1 - 2.4e-62 210.9 0.0 4.6e-57 193.5 0.0 2.2 2 0 0 2 2 2 2 Methylenetetrahydrofolate reductase WD40 PF00400.32 ETO18739.1 - 5.3e-32 109.3 29.3 1.8e-06 28.5 1.9 7.2 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18739.1 - 1e-11 44.9 2.4 0.1 12.9 0.0 5.6 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18739.1 - 2.1e-07 30.0 9.0 0.1 11.2 0.1 4.9 2 2 3 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO18739.1 - 0.089 11.5 7.2 1.3 7.7 2.3 3.3 2 2 0 2 2 2 0 Nup133 N terminal like DUF413 PF04219.12 ETO18740.1 - 0.012 15.6 0.1 0.024 14.6 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function, DUF DUF5357 PF17310.2 ETO18740.1 - 0.067 11.7 0.1 0.11 11.1 0.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5357) NAD_binding_1 PF00175.21 ETO18740.1 - 0.11 13.2 0.0 0.19 12.4 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain Dicty_REP PF05086.12 ETO18740.1 - 0.11 10.4 3.6 0.13 10.2 3.6 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 ETO18740.1 - 0.21 11.6 19.8 0.36 10.8 19.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein RIFIN PF02009.16 ETO18740.1 - 0.63 9.9 4.9 1.1 9.0 4.9 1.4 1 0 0 1 1 1 0 Rifin FSA_C PF10479.9 ETO18740.1 - 0.71 7.9 11.8 1.1 7.3 11.8 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus BSP_II PF05432.11 ETO18740.1 - 3.4 7.3 8.8 6.7 6.3 8.8 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) adh_short PF00106.25 ETO18741.1 - 1.4e-06 27.9 0.4 3.6e-06 26.6 0.0 1.8 2 0 0 2 2 2 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO18741.1 - 8.4e-06 25.5 0.1 1.7e-05 24.5 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase DUF3439 PF11921.8 ETO18741.1 - 0.018 15.0 7.3 0.032 14.2 7.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO18741.1 - 0.022 14.8 11.4 0.029 14.4 11.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein CDC45 PF02724.14 ETO18741.1 - 0.056 11.7 2.5 0.07 11.4 2.5 1.1 1 0 0 1 1 1 0 CDC45-like protein KR PF08659.10 ETO18741.1 - 0.059 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 KR domain BSP_II PF05432.11 ETO18741.1 - 0.074 12.7 17.4 0.096 12.4 17.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) MGC-24 PF05283.11 ETO18741.1 - 0.1 13.0 8.0 0.19 12.2 8.0 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Presenilin PF01080.17 ETO18741.1 - 0.15 10.8 2.4 0.17 10.6 2.4 1.1 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 ETO18741.1 - 0.76 9.9 9.1 0.92 9.6 9.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Sec62 PF03839.16 ETO18741.1 - 3.4 7.1 5.5 4.6 6.7 5.5 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 AAA_18 PF13238.6 ETO18743.1 - 1.1e-05 25.9 0.0 1.9e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain ADK PF00406.22 ETO18743.1 - 0.0008 19.5 0.0 0.013 15.6 0.0 2.1 1 1 0 1 1 1 1 Adenylate kinase AAA_22 PF13401.6 ETO18743.1 - 0.0093 16.2 0.0 0.021 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Ploopntkinase3 PF18751.1 ETO18743.1 - 0.014 15.3 0.0 0.019 14.9 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 Condensation PF00668.20 ETO18743.1 - 0.03 13.0 0.1 0.044 12.4 0.1 1.1 1 0 0 1 1 1 0 Condensation domain PduV-EutP PF10662.9 ETO18743.1 - 0.037 13.8 0.0 0.48 10.2 0.0 2.5 2 1 1 3 3 3 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ETO18743.1 - 0.038 14.5 0.0 0.051 14.1 0.0 1.3 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ETO18743.1 - 0.08 13.3 0.0 0.15 12.5 0.0 1.5 1 1 0 1 1 1 0 RNA helicase MMR_HSR1 PF01926.23 ETO18743.1 - 0.16 12.0 0.0 0.49 10.5 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase VasL PF12486.8 ETO18744.1 - 0.064 13.1 0.2 0.08 12.8 0.2 1.1 1 0 0 1 1 1 0 Type VI secretion system, EvfB, or VasL PDDEXK_6 PF04720.12 ETO18745.1 - 0.39 10.6 4.6 0.37 10.7 4.6 1.0 1 0 0 1 1 1 0 PDDEXK-like family of unknown function ETRAMP PF09716.10 ETO18745.1 - 3.8 7.6 9.8 4.4 7.4 9.8 1.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Na_H_Exchanger PF00999.21 ETO18746.1 - 3.4e-30 105.1 10.9 4e-30 104.9 10.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family FecCD PF01032.18 ETO18746.1 - 0.26 10.3 8.2 0.06 12.4 4.4 1.8 1 1 1 2 2 2 0 FecCD transport family EamA PF00892.20 ETO18746.1 - 2.4 8.4 9.8 0.33 11.1 3.4 2.4 2 1 1 3 3 3 0 EamA-like transporter family TPR_1 PF00515.28 ETO18747.1 - 3.2e-13 48.9 8.2 0.0018 18.0 0.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat PPP5 PF08321.12 ETO18747.1 - 1.9e-12 47.3 2.1 2.3e-10 40.6 0.0 3.0 2 1 1 3 3 3 1 PPP5 TPR repeat region TPR_2 PF07719.17 ETO18747.1 - 9.2e-12 44.1 4.3 0.002 18.1 0.3 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18747.1 - 1.8e-05 24.6 11.6 0.22 11.8 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO18747.1 - 0.0025 18.1 0.6 1.1 9.6 0.0 3.5 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18747.1 - 0.023 14.3 2.1 0.57 9.9 0.1 3.1 2 1 1 3 3 3 0 TPR repeat LEH PF07858.12 ETO18747.1 - 0.1 12.7 0.1 0.45 10.6 0.0 1.9 2 0 0 2 2 2 0 Limonene-1,2-epoxide hydrolase catalytic domain TPR_6 PF13174.6 ETO18747.1 - 0.28 11.9 4.7 13 6.7 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat FeoB_Cyto PF17910.1 ETO18747.1 - 0.51 10.9 4.0 0.53 10.9 1.0 2.2 2 0 0 2 2 2 0 FeoB cytosolic helical domain TrkA_TMD PF18613.1 ETO18749.1 - 0.12 11.8 6.7 0.38 10.2 6.7 1.9 1 0 0 1 1 1 0 Tyrosine kinase receptor A trans-membrane domain RGS PF00615.19 ETO18750.1 - 0.014 15.6 1.8 0.048 13.9 1.8 1.9 1 1 0 1 1 1 0 Regulator of G protein signaling domain GDC-P PF02347.16 ETO18751.1 - 7.1e-87 292.0 0.1 1.6e-86 290.9 0.0 1.6 2 0 0 2 2 2 1 Glycine cleavage system P-protein GDC-P PF02347.16 ETO18752.1 - 2.6e-06 26.6 0.5 1.9e-05 23.7 0.3 1.9 2 0 0 2 2 2 2 Glycine cleavage system P-protein DUF5395 PF17373.2 ETO18753.1 - 0.86 10.3 3.5 0.58 10.8 0.3 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5395) Y_phosphatase3 PF13350.6 ETO18754.1 - 0.07 13.1 0.2 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 Tyrosine phosphatase family Pkinase PF00069.25 ETO18755.1 - 9.4e-59 198.9 0.0 1e-58 198.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18755.1 - 3.9e-37 127.9 0.0 4.5e-37 127.7 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO18755.1 - 3.4e-07 29.9 0.0 6.8e-07 28.9 0.0 1.4 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO18755.1 - 0.00016 21.7 0.0 0.00026 21.0 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO18755.1 - 0.0015 18.0 0.3 0.0029 17.0 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO18755.1 - 0.023 13.5 0.0 0.039 12.7 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 ETO18755.1 - 0.12 11.4 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ETO18755.1 - 0.14 11.0 0.1 0.18 10.7 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain Astro_capsid_p PF12226.8 ETO18756.1 - 0.00015 21.0 15.3 0.00015 21.0 15.3 3.3 2 1 1 3 3 3 1 Turkey astrovirus capsid protein TPR_12 PF13424.6 ETO18756.1 - 0.0077 16.5 1.8 0.027 14.7 1.8 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18756.1 - 0.014 15.6 0.5 0.014 15.6 0.5 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18756.1 - 0.35 11.1 2.5 13 6.2 0.2 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat BUD22 PF09073.10 ETO18756.1 - 6 6.1 80.4 1.4 8.2 42.6 2.1 2 0 0 2 2 2 0 BUD22 Alpha-amylase PF00128.24 ETO18757.1 - 0.00015 21.4 0.0 0.0002 21.0 0.0 1.1 1 0 0 1 1 1 1 Alpha amylase, catalytic domain PK PF00224.21 ETO18758.1 - 4.2e-132 440.3 12.2 1.7e-90 303.5 4.6 2.1 1 1 1 2 2 2 2 Pyruvate kinase, barrel domain PK_C PF02887.16 ETO18758.1 - 1.4e-26 93.0 0.6 1.9e-25 89.3 0.1 2.8 3 0 0 3 3 3 1 Pyruvate kinase, alpha/beta domain HpcH_HpaI PF03328.14 ETO18758.1 - 0.00083 18.5 0.6 0.0022 17.2 0.5 1.8 1 1 0 1 1 1 1 HpcH/HpaI aldolase/citrate lyase family ENTH PF01417.20 ETO18759.1 - 4.5e-11 42.9 0.1 6.5e-11 42.4 0.1 1.2 1 0 0 1 1 1 1 ENTH domain Glyco_tran_WbsX PF14307.6 ETO18759.1 - 0.12 11.8 2.5 0.55 9.6 0.6 2.0 2 0 0 2 2 2 0 Glycosyltransferase WbsX PDEase_I PF00233.19 ETO18760.1 - 2.7e-31 109.1 2.0 4e-31 108.6 2.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETO18760.1 - 0.0021 18.3 0.1 0.0044 17.2 0.1 1.6 2 0 0 2 2 2 1 HD domain PDEase_I PF00233.19 ETO18761.1 - 1.8e-26 93.4 0.0 1.8e-26 93.4 0.0 2.5 2 1 1 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase PDEase_I PF00233.19 ETO18762.1 - 2.1e-74 250.3 0.0 3.4e-74 249.6 0.0 1.3 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETO18762.1 - 0.051 13.8 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 HD domain LAP1C PF05609.12 ETO18763.1 - 0.014 14.5 10.5 0.026 13.6 10.5 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Sortase PF04203.13 ETO18764.1 - 0.008 16.0 0.9 0.011 15.6 0.9 1.4 1 1 0 1 1 1 1 Sortase domain Cadherin PF00028.17 ETO18764.1 - 0.22 12.0 1.3 1.5 9.3 0.1 2.6 1 1 1 2 2 2 0 Cadherin domain TraU PF06834.11 ETO18765.1 - 0.042 13.1 0.4 0.048 12.9 0.4 1.2 1 0 0 1 1 1 0 TraU protein Peroxin-13_N PF04088.13 ETO18765.1 - 0.31 11.3 3.0 0.47 10.7 3.0 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region Tubulin PF00091.25 ETO18766.1 - 1.2e-69 234.5 0.0 1.8e-69 233.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO18766.1 - 2.9e-33 114.7 0.1 1.6e-26 93.0 0.1 2.3 1 1 1 2 2 2 2 Tubulin C-terminal domain Tubulin_3 PF14881.6 ETO18766.1 - 0.0022 17.7 0.0 0.0035 17.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin domain Cwf_Cwc_15 PF04889.12 ETO18767.1 - 7.2e-05 22.6 13.8 8.3e-05 22.4 13.8 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 ETO18767.1 - 0.012 16.0 7.4 0.25 11.7 0.9 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UNC-79 PF14776.6 ETO18767.1 - 0.067 11.9 2.5 0.088 11.5 2.5 1.1 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 DUF3395 PF11875.8 ETO18767.1 - 0.31 10.9 13.3 0.63 9.9 13.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3395) WASH-7_C PF14746.6 ETO18767.1 - 0.69 9.6 6.9 1.2 8.8 0.1 2.4 2 1 0 2 2 2 0 WASH complex subunit 7, C-terminal PRAS PF15798.5 ETO18767.1 - 1.2 9.8 5.3 1.3 9.7 1.2 2.2 2 0 0 2 2 2 0 Proline-rich AKT1 substrate 1 CENP-B_dimeris PF09026.10 ETO18767.1 - 1.4 9.3 8.7 1.5 9.2 1.6 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FHIPEP PF00771.20 ETO18767.1 - 1.9 6.9 6.3 1.1 7.7 4.8 1.3 1 1 0 1 1 1 0 FHIPEP family Orf78 PF06024.12 ETO18767.1 - 6 7.2 5.4 8.6 6.7 0.5 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Barttin PF15462.6 ETO18768.1 - 0.11 12.2 1.6 0.15 11.8 1.6 1.2 1 0 0 1 1 1 0 Bartter syndrome, infantile, with sensorineural deafness (Barttin) Menin PF05053.13 ETO18768.1 - 0.44 8.9 8.7 0.51 8.6 8.7 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO18768.1 - 1.3 9.6 21.1 2.8 8.6 21.1 1.7 1 1 0 1 1 1 0 Secretin N-terminal domain RabGAP-TBC PF00566.18 ETO18768.1 - 2 8.0 9.4 0.3 10.7 0.3 2.5 2 1 0 2 2 2 0 Rab-GTPase-TBC domain Presenilin PF01080.17 ETO18768.1 - 5.9 5.6 8.9 6.9 5.3 8.9 1.1 1 0 0 1 1 1 0 Presenilin FMO-like PF00743.19 ETO18769.1 - 4.5e-19 68.3 0.0 2e-17 62.9 0.0 2.0 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ETO18769.1 - 5.4e-13 48.9 0.0 8.1e-13 48.3 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO18769.1 - 1.5e-12 47.4 0.0 2.2e-12 46.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO18769.1 - 1.4e-06 28.4 0.0 2.8e-06 27.4 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox PF00070.27 ETO18769.1 - 0.0001 22.8 0.0 0.015 15.9 0.0 2.6 3 0 0 3 3 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETO18769.1 - 0.00044 19.9 0.1 0.071 12.7 0.1 2.1 1 1 1 2 2 2 2 FAD dependent oxidoreductase K_oxygenase PF13434.6 ETO18769.1 - 0.00067 18.9 0.0 0.36 9.9 0.0 2.5 2 1 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) NAD_binding_9 PF13454.6 ETO18769.1 - 0.03 14.3 0.2 0.48 10.4 0.0 2.2 1 1 0 2 2 2 0 FAD-NAD(P)-binding FAD_binding_3 PF01494.19 ETO18769.1 - 0.038 13.2 0.1 0.072 12.3 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain FAD_binding_2 PF00890.24 ETO18769.1 - 0.08 12.0 0.0 0.14 11.2 0.0 1.4 1 0 0 1 1 1 0 FAD binding domain Amino_oxidase PF01593.24 ETO18769.1 - 0.08 12.2 0.0 0.63 9.3 0.0 2.0 2 0 0 2 2 2 0 Flavin containing amine oxidoreductase Menin PF05053.13 ETO18770.1 - 1.1 7.5 11.3 1.2 7.5 11.3 1.2 1 0 0 1 1 1 0 Menin FtsJ PF01728.19 ETO18772.1 - 9.6e-07 29.1 0.0 2.1e-06 27.9 0.0 1.5 1 1 0 1 1 1 1 FtsJ-like methyltransferase PLATZ PF04640.14 ETO18773.1 - 0.26 12.0 3.7 0.19 12.4 0.7 2.1 2 0 0 2 2 2 0 PLATZ transcription factor Ecl1 PF12855.7 ETO18773.1 - 0.37 11.9 0.5 0.37 11.9 0.5 2.4 2 1 0 2 2 2 0 ECL1/2/3 zinc binding proteins Pkinase PF00069.25 ETO18774.1 - 0.0032 16.9 0.0 0.0041 16.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain HA2 PF04408.23 ETO18775.1 - 0.085 13.2 0.1 0.13 12.5 0.1 1.3 1 0 0 1 1 1 0 Helicase associated domain (HA2) PIG-F PF06699.11 ETO18775.1 - 0.14 12.3 0.7 0.16 12.1 0.7 1.1 1 0 0 1 1 1 0 GPI biosynthesis protein family Pig-F SPARC_Ca_bdg PF10591.9 ETO18776.1 - 0.0049 17.2 0.3 0.0071 16.7 0.3 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Folliculin PF11704.8 ETO18776.1 - 0.018 14.9 0.4 0.02 14.7 0.4 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Pkinase PF00069.25 ETO18777.1 - 2.9e-43 148.1 0.0 4.3e-43 147.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18777.1 - 4.7e-28 98.2 0.0 6.1e-28 97.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO18777.1 - 5.8e-05 22.6 0.0 8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kelch_6 PF13964.6 ETO18778.1 - 0.0001 22.4 1.7 0.19 12.1 0.2 4.8 6 0 0 6 6 6 1 Kelch motif Atrophin-1 PF03154.15 ETO18780.1 - 0.0017 16.7 0.6 0.002 16.5 0.6 1.1 1 0 0 1 1 1 1 Atrophin-1 family Tim54 PF11711.8 ETO18780.1 - 0.0041 16.0 0.9 0.0041 16.0 0.9 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Phage_Gp23 PF10669.9 ETO18780.1 - 0.026 14.9 2.0 0.038 14.3 2.0 1.3 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) XAP5 PF04921.14 ETO18780.1 - 0.034 14.0 7.0 0.048 13.5 7.0 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator Usp PF00582.26 ETO18780.1 - 0.041 14.4 3.1 0.074 13.6 3.1 1.4 1 0 0 1 1 1 0 Universal stress protein family Roughex PF06020.11 ETO18780.1 - 0.061 12.4 8.1 0.085 11.9 8.1 1.2 1 0 0 1 1 1 0 Drosophila roughex protein TERB2 PF15101.6 ETO18780.1 - 0.089 12.8 1.0 0.12 12.4 1.0 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Presenilin PF01080.17 ETO18780.1 - 0.11 11.2 0.3 0.1 11.4 0.3 1.2 1 0 0 1 1 1 0 Presenilin RRN3 PF05327.11 ETO18780.1 - 0.22 10.1 5.2 0.28 9.7 5.2 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CPSF100_C PF13299.6 ETO18780.1 - 0.23 11.6 3.4 0.34 11.1 3.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Sec62 PF03839.16 ETO18780.1 - 0.24 10.9 0.8 0.32 10.5 0.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Radial_spoke PF04712.12 ETO18780.1 - 0.26 10.2 8.0 0.36 9.7 8.0 1.3 1 0 0 1 1 1 0 Radial spokehead-like protein THOC2_N PF16134.5 ETO18780.1 - 0.26 9.9 7.5 0.32 9.6 7.5 1.1 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus TRAP_alpha PF03896.16 ETO18780.1 - 0.33 10.1 9.1 0.54 9.4 9.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 ETO18780.1 - 0.82 9.3 9.8 0.38 10.4 6.2 2.1 2 0 0 2 2 2 0 FAM176 family Connexin PF00029.19 ETO18780.1 - 0.97 9.1 2.3 1.3 8.7 2.3 1.2 1 0 0 1 1 1 0 Connexin CDC45 PF02724.14 ETO18780.1 - 1.2 7.4 10.2 1.5 7.0 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Coilin_N PF15862.5 ETO18780.1 - 3.8 7.3 11.6 64 3.3 0.0 2.1 2 0 0 2 2 2 0 Coilin N-terminus Nop14 PF04147.12 ETO18780.1 - 6.2 4.9 16.1 9.1 4.3 16.1 1.2 1 0 0 1 1 1 0 Nop14-like family GOLD_2 PF13897.6 ETO18780.1 - 6.3 7.3 7.2 1.9 8.9 3.6 1.8 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking ERF PF04404.12 ETO18780.1 - 8 6.3 9.1 14 5.5 6.1 2.2 2 0 0 2 2 2 0 ERF superfamily RPN2_C PF18004.1 ETO18780.1 - 8.2 6.3 14.3 0.59 10.0 9.6 1.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain MAP17 PF15807.5 ETO18781.1 - 0.1 12.8 1.2 0.11 12.7 1.2 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 ANAPC15 PF15243.6 ETO18781.1 - 0.13 12.6 11.5 0.15 12.5 11.5 1.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 DUF4637 PF15470.6 ETO18781.1 - 0.54 10.0 10.4 0.57 9.9 10.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CobT PF06213.12 ETO18781.1 - 0.9 8.9 9.2 0.87 8.9 9.2 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM176 PF14851.6 ETO18781.1 - 1.8 8.2 7.8 2 8.1 7.8 1.1 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 ETO18781.1 - 2.6 7.8 10.3 2.8 7.7 10.3 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Paf1 PF03985.13 ETO18781.1 - 4 6.3 11.3 3.6 6.5 11.3 1.0 1 0 0 1 1 1 0 Paf1 DNA_pol_phi PF04931.13 ETO18781.1 - 6.3 4.8 11.1 6.1 4.8 11.1 1.0 1 0 0 1 1 1 0 DNA polymerase phi HMA PF00403.26 ETO18782.1 - 0.027 14.9 0.2 0.066 13.7 0.0 1.7 2 0 0 2 2 2 0 Heavy-metal-associated domain SLX9 PF15341.6 ETO18782.1 - 0.15 12.5 10.1 0.3 11.5 10.1 1.4 1 0 0 1 1 1 0 Ribosome biogenesis protein SLX9 TraT PF05818.12 ETO18782.1 - 0.16 11.7 0.1 0.16 11.7 0.1 2.1 1 1 1 2 2 2 0 Enterobacterial TraT complement resistance protein SecM PF06558.12 ETO18782.1 - 0.23 11.5 2.6 0.54 10.4 2.6 1.6 1 0 0 1 1 1 0 Secretion monitor precursor protein (SecM) U1snRNP70_N PF12220.8 ETO18782.1 - 0.35 11.5 8.0 0.46 11.1 6.1 2.1 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Presenilin PF01080.17 ETO18782.1 - 3.9 6.1 6.7 5.8 5.6 6.7 1.2 1 0 0 1 1 1 0 Presenilin ABC_tran PF00005.27 ETO18783.1 - 5e-23 82.1 0.0 9.8e-23 81.2 0.0 1.5 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ETO18783.1 - 1.7e-07 31.2 1.6 2.1e-06 27.6 0.1 2.2 2 0 0 2 2 2 1 ABC transporter transmembrane region AAA_16 PF13191.6 ETO18783.1 - 0.0046 17.4 0.0 0.015 15.7 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO18783.1 - 0.027 14.2 0.1 0.08 12.7 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ETO18783.1 - 0.1 12.3 3.2 0.12 12.2 0.1 2.4 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system MFS_1 PF07690.16 ETO18784.1 - 5.6e-05 22.2 17.9 5.6e-05 22.2 17.9 2.0 2 0 0 2 2 2 1 Major Facilitator Superfamily KRE1 PF17056.5 ETO18784.1 - 0.04 13.6 0.7 1.5 8.6 0.7 2.4 1 1 0 1 1 1 0 Killer toxin-resistance protein 1 Hexapep PF00132.24 ETO18785.1 - 5.1e-06 26.0 8.1 5.6e-05 22.7 1.8 2.6 1 1 1 2 2 2 2 Bacterial transferase hexapeptide (six repeats) RRM_1 PF00076.22 ETO18785.1 - 5.8e-05 22.8 0.0 0.00012 21.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MspA PF09203.11 ETO18785.1 - 0.0013 18.6 0.7 0.0013 18.6 0.7 2.1 2 0 0 2 2 2 1 MspA RL PF17797.1 ETO18785.1 - 0.002 18.1 0.0 0.0049 16.8 0.0 1.6 1 0 0 1 1 1 1 RL domain Hexapep_2 PF14602.6 ETO18785.1 - 0.12 12.1 12.0 0.21 11.4 3.1 2.4 1 1 1 2 2 2 0 Hexapeptide repeat of succinyl-transferase TilS_C PF11734.8 ETO18787.1 - 0.087 12.3 0.0 0.19 11.2 0.0 1.5 1 0 0 1 1 1 0 TilS substrate C-terminal domain Eaf7 PF07904.13 ETO18787.1 - 1.8 9.0 4.8 6.6 7.2 4.8 2.0 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 DUF4791 PF16039.5 ETO18788.1 - 0.019 14.5 0.0 0.025 14.1 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4791) HIT PF01230.23 ETO18789.1 - 1.3e-08 35.5 0.0 2.3e-08 34.7 0.0 1.5 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ETO18789.1 - 0.00058 20.3 0.0 0.0011 19.4 0.0 1.5 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Cu_bind_like PF02298.17 ETO18789.1 - 0.022 14.8 0.5 0.1 12.7 0.7 2.0 2 0 0 2 2 2 0 Plastocyanin-like domain ACOX PF01756.19 ETO18789.1 - 0.059 12.9 0.2 0.59 9.7 0.0 2.3 3 0 0 3 3 3 0 Acyl-CoA oxidase Nudc_N PF14050.6 ETO18789.1 - 0.084 12.9 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 N-terminal conserved domain of Nudc. WD40 PF00400.32 ETO18790.1 - 1.2e-35 120.9 26.2 1e-06 29.3 0.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18790.1 - 5.2e-08 33.1 1.1 0.73 10.2 0.0 5.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18790.1 - 0.00014 20.7 6.1 0.22 10.1 0.0 4.4 1 1 2 5 5 5 3 Nucleoporin Nup120/160 ADP_ribosyl_GH PF03747.14 ETO18791.1 - 4.1e-36 125.2 0.0 7.5e-36 124.3 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Peptidase_S10 PF00450.22 ETO18792.1 - 7.5e-36 124.4 0.7 5.3e-26 92.0 0.0 2.0 2 0 0 2 2 2 2 Serine carboxypeptidase Otopetrin PF03189.13 ETO18793.1 - 0.00011 21.1 0.5 0.14 11.0 0.0 3.1 1 1 1 2 2 2 1 Otopetrin UIM PF02809.20 ETO18794.1 - 0.023 14.6 0.2 0.072 13.0 0.2 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif KRE9 PF05390.11 ETO18795.1 - 0.16 12.7 0.9 3.1 8.6 0.7 2.8 2 1 0 2 2 2 0 Yeast cell wall synthesis protein KRE9/KNH1 HEAT PF02985.22 ETO18795.1 - 0.89 10.0 2.3 2 8.9 0.0 2.8 3 0 0 3 3 3 0 HEAT repeat Pkinase PF00069.25 ETO18796.1 - 6.6e-26 91.3 0.0 1.1e-25 90.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18796.1 - 6.2e-11 42.1 0.0 1.4e-10 40.9 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1759 PF03564.15 ETO18796.1 - 0.014 15.4 0.7 0.091 12.7 0.1 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1759) SporV_AA PF12164.8 ETO18797.1 - 0.042 14.2 0.1 0.062 13.7 0.1 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AA Phage_holin_2_1 PF04971.12 ETO18797.1 - 9.4 6.3 7.4 23 5.1 0.1 2.4 2 0 0 2 2 2 0 Bacteriophage P21 holin S RPEL PF02755.15 ETO18798.1 - 0.003 17.2 4.3 0.5 10.1 0.1 2.6 2 0 0 2 2 2 2 RPEL repeat PRELI PF04707.14 ETO18798.1 - 0.014 15.3 2.8 0.059 13.2 0.8 2.1 1 1 1 2 2 2 0 PRELI-like family KH_7 PF17214.3 ETO18798.1 - 0.014 15.4 0.3 0.026 14.5 0.3 1.5 1 0 0 1 1 1 0 KH domain ABC_tran PF00005.27 ETO18800.1 - 2.8e-12 47.3 0.0 7.1e-12 46.0 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ETO18800.1 - 0.0016 18.3 0.1 0.003 17.4 0.1 1.4 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ETO18800.1 - 0.015 15.6 0.2 0.37 11.1 0.2 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ETO18800.1 - 0.03 13.7 0.0 0.041 13.3 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Erv26 PF04148.13 ETO18800.1 - 0.052 13.4 0.2 0.07 13.0 0.2 1.2 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 RIC1 PF07064.13 ETO18802.1 - 3.7e-18 65.9 2.4 1.2e-15 57.6 0.1 2.8 3 0 0 3 3 3 2 RIC1 Apis_Csd PF11671.8 ETO18802.1 - 1.7 8.6 8.9 4.9 7.2 8.9 1.7 1 0 0 1 1 1 0 Complementary sex determiner protein PP2C PF00481.21 ETO18803.1 - 7.1e-22 78.3 0.0 7.8e-21 74.9 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ETO18803.1 - 0.0095 15.9 0.0 1.4 8.8 0.0 2.2 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) Pkinase PF00069.25 ETO18804.1 - 5e-62 209.7 0.1 4.8e-61 206.4 0.1 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18804.1 - 6.1e-33 114.2 0.2 1.6e-25 89.9 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ETO18804.1 - 0.0018 18.2 0.6 0.012 15.5 0.5 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO18804.1 - 0.0023 16.9 0.0 0.0053 15.8 0.0 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO18804.1 - 0.0025 16.6 0.7 0.0044 15.9 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO18804.1 - 0.0032 16.9 0.0 0.0066 15.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETO18804.1 - 0.023 14.3 0.0 0.062 12.9 0.0 1.7 1 0 0 1 1 1 0 RIO1 family Utp14 PF04615.13 ETO18805.1 - 8.1 4.9 30.7 14 4.1 30.7 1.3 1 0 0 1 1 1 0 Utp14 protein Leptin PF02024.15 ETO18806.1 - 0.07 12.9 0.3 0.23 11.2 0.1 1.8 1 1 1 2 2 2 0 Leptin LAP1C PF05609.12 ETO18807.1 - 0.9 8.6 27.0 1.2 8.1 27.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hamartin PF04388.12 ETO18807.1 - 7 5.2 23.9 9.4 4.8 23.9 1.1 1 0 0 1 1 1 0 Hamartin protein FAD_binding_3 PF01494.19 ETO18808.1 - 8.6e-12 45.0 0.1 2.4e-07 30.4 0.0 2.3 2 0 0 2 2 2 2 FAD binding domain Pyr_redox_3 PF13738.6 ETO18808.1 - 3.4e-07 29.8 0.1 5.4e-06 25.9 0.1 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETO18808.1 - 7.3e-07 29.1 0.0 8.9e-07 28.8 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETO18808.1 - 2.2e-06 27.1 0.1 3e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ETO18808.1 - 2.1e-05 23.4 0.3 4.1e-05 22.5 0.0 1.6 2 0 0 2 2 2 1 HI0933-like protein NAD_binding_8 PF13450.6 ETO18808.1 - 3.2e-05 24.1 0.0 5.7e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETO18808.1 - 0.00028 20.2 0.0 0.00046 19.5 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase C5-epim_C PF06662.13 ETO18808.1 - 0.0071 15.9 0.2 0.067 12.7 0.1 2.2 2 0 0 2 2 2 1 D-glucuronyl C5-epimerase C-terminus Pyr_redox PF00070.27 ETO18808.1 - 0.041 14.4 0.0 0.084 13.4 0.0 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Lycopene_cycl PF05834.12 ETO18808.1 - 0.064 12.3 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein FAD_oxidored PF12831.7 ETO18808.1 - 0.078 12.3 0.2 0.23 10.8 0.0 1.7 2 0 0 2 2 2 0 FAD dependent oxidoreductase GIDA PF01134.22 ETO18808.1 - 0.15 11.1 0.2 0.27 10.3 0.1 1.5 2 0 0 2 2 2 0 Glucose inhibited division protein A SR-25 PF10500.9 ETO18808.1 - 0.23 11.0 4.3 0.43 10.2 4.3 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1699 PF08004.11 ETO18809.1 - 0.00015 21.5 0.3 2.8 7.6 0.0 3.2 2 1 1 3 3 3 3 Protein of unknown function (DUF1699) DUF2796 PF10986.8 ETO18809.1 - 0.023 14.7 0.1 0.092 12.7 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF2796) PA28_beta PF02252.18 ETO18811.1 - 6.6e-43 145.8 0.8 6.6e-43 145.8 0.8 1.6 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETO18811.1 - 0.00037 20.5 1.7 0.0012 18.9 0.4 2.6 3 0 0 3 3 3 1 Proteasome activator pa28 alpha subunit CF222 PF15661.5 ETO18811.1 - 0.014 14.3 0.3 0.016 14.1 0.3 1.1 1 0 0 1 1 1 0 C6orf222, uncharacterised family ANAPC4_WD40 PF12894.7 ETO18813.1 - 0.00037 20.7 0.0 0.0028 17.9 0.0 2.4 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ETO18813.1 - 0.00095 19.6 1.2 1.2 9.7 0.0 4.0 5 0 0 5 5 5 2 PQQ-like domain Serglycin PF04360.12 ETO18814.1 - 0.87 9.5 14.8 1.3 9.0 2.4 2.5 1 1 1 2 2 2 0 Serglycin LAP1C PF05609.12 ETO18814.1 - 1.4 7.9 17.6 1.7 7.6 17.6 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Vps8 PF12816.7 ETO18817.1 - 2.2e-16 59.9 7.1 4.1e-16 59.1 1.6 3.1 2 1 0 2 2 2 1 Golgi CORVET complex core vacuolar protein 8 VIT1 PF01988.19 ETO18817.1 - 0.61 9.9 1.6 1.4 8.8 1.6 1.5 1 0 0 1 1 1 0 VIT family NOA36 PF06524.12 ETO18817.1 - 0.74 9.1 6.8 1.1 8.5 6.8 1.2 1 0 0 1 1 1 0 NOA36 protein Annexin PF00191.20 ETO18818.1 - 7.4e-09 35.6 0.5 4.6e-08 33.0 0.0 2.3 2 0 0 2 2 2 1 Annexin NESP55 PF06390.12 ETO18818.1 - 0.024 14.2 7.9 0.04 13.5 7.9 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Jacalin PF01419.17 ETO18818.1 - 0.062 13.2 1.8 0.11 12.5 1.3 1.6 2 0 0 2 2 2 0 Jacalin-like lectin domain Na_trans_assoc PF06512.13 ETO18818.1 - 0.098 12.9 4.4 0.17 12.2 4.4 1.4 1 0 0 1 1 1 0 Sodium ion transport-associated EF-hand_1 PF00036.32 ETO18818.1 - 0.1 12.2 0.0 0.25 11.0 0.0 1.6 1 0 0 1 1 1 0 EF hand BPL_N PF09825.9 ETO18818.1 - 0.29 10.2 2.9 0.44 9.6 2.9 1.2 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF2052 PF09747.9 ETO18818.1 - 0.92 9.6 8.9 3 7.9 0.0 2.2 1 1 1 2 2 2 0 Coiled-coil domain containing protein (DUF2052) NOA36 PF06524.12 ETO18818.1 - 2.6 7.3 6.5 8.9 5.5 6.7 1.7 2 0 0 2 2 2 0 NOA36 protein zf-AN1 PF01428.16 ETO18819.1 - 3.9e-05 23.7 2.0 3.9e-05 23.7 2.0 2.6 2 0 0 2 2 2 1 AN1-like Zinc finger FAM176 PF14851.6 ETO18819.1 - 0.87 9.2 4.5 1.6 8.4 4.5 1.4 1 0 0 1 1 1 0 FAM176 family DUF1242 PF06842.12 ETO18820.1 - 0.14 12.0 0.2 0.27 11.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1242) Plasmodium_HRP PF05403.11 ETO18821.1 - 0.0013 18.6 0.0 0.093 12.5 0.0 2.6 1 1 1 2 2 2 2 Plasmodium histidine-rich protein (HRPII/III) MMS1_N PF10433.9 ETO18822.1 - 2.6e-09 36.3 0.5 3.2e-09 35.9 0.5 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term NOA36 PF06524.12 ETO18823.1 - 0.0087 15.4 4.6 0.011 15.0 4.6 1.1 1 0 0 1 1 1 1 NOA36 protein Secretin_N_2 PF07655.13 ETO18823.1 - 8.2 7.0 18.1 2.8 8.6 10.3 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Ank_4 PF13637.6 ETO18824.1 - 6.4e-16 58.5 0.1 0.00011 22.7 0.0 4.2 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO18824.1 - 4.4e-14 52.8 0.0 9.3e-05 22.9 0.1 3.5 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO18824.1 - 4.7e-12 45.9 1.2 2.9e-06 27.5 0.1 4.8 4 1 1 5 5 5 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO18824.1 - 8.1e-12 44.3 0.0 0.019 15.5 0.0 5.5 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ETO18824.1 - 9.1e-08 32.2 2.7 0.026 15.0 0.0 5.0 6 0 0 6 6 6 2 Ankyrin repeat Pkinase PF00069.25 ETO18825.1 - 7e-12 45.3 2.5 2.2e-11 43.7 2.5 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO18825.1 - 7e-08 32.1 1.9 9.7e-07 28.3 1.9 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase EBV-NA3 PF05009.12 ETO18825.1 - 0.11 12.0 0.1 0.14 11.6 0.1 1.1 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) WD40 PF00400.32 ETO18826.1 - 9.7e-24 83.2 11.2 9.2e-07 29.5 0.4 4.9 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18826.1 - 1.5e-06 28.4 1.8 0.12 12.7 0.1 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18826.1 - 5.6e-05 22.0 0.8 1.3 7.6 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO18826.1 - 0.046 13.8 2.9 6.4 6.9 0.6 3.8 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, middle region LydB PF16084.5 ETO18826.1 - 0.11 12.4 0.2 0.21 11.4 0.1 1.5 1 1 0 1 1 1 0 LydA-holin antagonist RSB_motif PF16294.5 ETO18828.1 - 1.2 9.5 18.4 3 8.2 0.4 2.6 3 1 0 3 3 3 0 RNSP1-SAP18 binding (RSB) motif DUF2956 PF11169.8 ETO18828.1 - 3.6 7.8 6.1 4.7 7.4 5.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) BUD22 PF09073.10 ETO18828.1 - 5.7 6.2 17.5 7.1 5.9 17.5 1.1 1 0 0 1 1 1 0 BUD22 DBR1 PF05011.13 ETO18829.1 - 1.3e-14 54.8 0.3 2.8e-14 53.7 0.3 1.6 1 0 0 1 1 1 1 Lariat debranching enzyme, C-terminal domain fn3_PAP PF17808.1 ETO18830.1 - 0.085 13.0 0.1 0.16 12.1 0.1 1.4 1 0 0 1 1 1 0 Fn3-like domain from Purple Acid Phosphatase Claudin_3 PF06653.11 ETO18832.1 - 0.011 15.6 0.1 0.02 14.8 0.1 1.4 1 0 0 1 1 1 0 Tight junction protein, Claudin-like SGT1 PF07093.11 ETO18832.1 - 0.058 11.8 7.3 0.089 11.2 7.3 1.2 1 0 0 1 1 1 0 SGT1 protein DNA_pol_phi PF04931.13 ETO18832.1 - 0.099 10.7 13.9 0.18 9.9 13.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi YL1 PF05764.13 ETO18832.1 - 0.11 12.6 15.9 0.24 11.5 15.9 1.5 1 0 0 1 1 1 0 YL1 nuclear protein CobT PF06213.12 ETO18832.1 - 0.12 11.8 10.2 0.22 10.9 10.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Voldacs PF03517.13 ETO18832.1 - 0.16 12.1 7.7 0.081 13.0 5.1 1.9 2 0 0 2 2 1 0 Regulator of volume decrease after cellular swelling Presenilin PF01080.17 ETO18832.1 - 0.23 10.2 1.9 0.35 9.6 1.9 1.4 1 0 0 1 1 1 0 Presenilin Mif2_N PF15624.6 ETO18832.1 - 0.25 12.0 9.4 0.099 13.3 6.2 1.9 2 0 0 2 2 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal RPN2_C PF18004.1 ETO18832.1 - 0.25 11.2 14.0 1.3 9.0 14.6 1.8 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain RNA_polI_A34 PF08208.11 ETO18832.1 - 0.3 11.1 13.1 0.52 10.4 13.1 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 ETO18832.1 - 0.42 10.4 8.9 0.97 9.2 8.9 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ORC_WH_C PF18137.1 ETO18832.1 - 0.5 10.4 7.0 1.3 9.0 7.0 1.7 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal RRN3 PF05327.11 ETO18832.1 - 0.52 8.8 6.0 0.12 10.9 2.7 1.7 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Nop14 PF04147.12 ETO18832.1 - 0.56 8.4 16.3 1.4 7.1 16.3 1.5 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 ETO18832.1 - 0.59 10.5 6.9 1 9.8 6.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 ETO18832.1 - 0.81 8.8 7.7 1.4 8.0 7.7 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 ETO18832.1 - 0.89 7.8 13.2 1.3 7.3 13.2 1.2 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 ETO18832.1 - 1.8 8.7 6.7 3.6 7.7 6.7 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 ETO18832.1 - 2.1 8.0 12.2 1.6 8.4 10.1 1.9 2 0 0 2 2 2 0 FAM176 family NOA36 PF06524.12 ETO18832.1 - 2.5 7.3 18.6 4.8 6.4 18.6 1.4 1 0 0 1 1 1 0 NOA36 protein TFB6 PF17110.5 ETO18832.1 - 3.1 7.5 9.0 9.1 6.0 9.0 1.8 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH AIF_C PF14721.6 ETO18832.1 - 4.8 7.5 7.1 14 6.0 7.1 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Sporozoite_P67 PF05642.11 ETO18832.1 - 5.9 4.8 10.1 8.2 4.4 10.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Dicty_REP PF05086.12 ETO18832.1 - 7.1 4.5 13.9 0.96 7.3 9.3 1.8 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein UPF0239 PF06783.11 ETO18832.1 - 8.2 6.7 7.9 4.9e+02 1.0 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) SSP160 PF06933.11 ETO18833.1 - 6.3 4.9 15.2 8 4.5 15.2 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DHHC PF01529.20 ETO18834.1 - 2.4e-35 121.6 10.6 4.8e-35 120.6 10.6 1.4 1 1 0 1 1 1 1 DHHC palmitoyltransferase RMP PF14996.6 ETO18834.1 - 0.098 12.9 3.5 0.15 12.3 3.5 1.2 1 0 0 1 1 1 0 Retinal Maintenance Lin-8 PF03353.15 ETO18834.1 - 0.87 9.1 2.1 1.2 8.6 2.1 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist DUF1635 PF07795.11 ETO18834.1 - 1.4 8.7 4.7 2.1 8.2 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) SR-25 PF10500.9 ETO18834.1 - 2.3 7.8 17.3 3.1 7.3 17.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF1272 PF06906.11 ETO18834.1 - 3.6 7.7 8.8 11 6.2 8.8 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1272) Kelch_6 PF13964.6 ETO18835.1 - 7.8e-08 32.3 4.3 0.0048 17.1 0.2 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO18835.1 - 6.4e-07 29.2 1.9 0.0025 17.8 0.3 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO18835.1 - 1.4e-05 25.0 0.3 0.0016 18.4 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO18835.1 - 3.8e-05 23.8 0.0 0.0031 17.7 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO18835.1 - 0.0007 19.1 2.2 0.044 13.4 0.3 2.9 3 0 0 3 3 3 1 Kelch motif TPR_MLP1_2 PF07926.12 ETO18835.1 - 0.0012 18.9 0.2 0.0022 18.1 0.2 1.3 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein Kelch_2 PF07646.15 ETO18835.1 - 0.0073 16.2 3.0 11 6.2 0.1 4.4 5 0 0 5 5 5 2 Kelch motif GF_recep_IV PF14843.6 ETO18835.1 - 0.11 12.3 0.8 0.24 11.2 0.3 1.7 2 0 0 2 2 2 0 Growth factor receptor domain IV WD40 PF00400.32 ETO18836.1 - 9.1e-51 168.7 9.0 1.6e-09 38.2 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18836.1 - 2.9e-25 88.4 0.2 0.00014 22.1 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO18836.1 - 4.6e-12 45.5 0.3 0.1 11.5 0.0 5.7 2 2 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO18836.1 - 2.2e-10 40.4 0.5 0.01 15.2 0.0 3.8 1 1 2 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO18836.1 - 2.7e-09 37.2 0.3 0.0046 16.9 0.0 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO18836.1 - 1.2e-05 25.1 2.4 3.4 7.7 0.1 4.0 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO18836.1 - 7e-05 22.4 0.4 0.96 9.2 0.0 3.5 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature Nup160 PF11715.8 ETO18836.1 - 0.00022 20.0 1.5 1.6 7.3 0.1 4.1 3 2 0 3 3 3 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO18836.1 - 0.0004 20.5 0.6 1 9.5 0.1 4.0 2 1 1 4 4 4 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO18836.1 - 0.011 14.5 6.6 5.2 5.7 0.2 4.1 1 1 1 4 4 4 0 Nup133 N terminal like Utp8 PF10395.9 ETO18836.1 - 0.042 12.3 0.0 0.14 10.6 0.0 1.8 2 0 0 2 2 2 0 Utp8 family Kelch_6 PF13964.6 ETO18837.1 - 4.1e-08 33.2 2.1 0.04 14.2 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO18837.1 - 0.0029 17.5 1.5 1.7 8.7 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO18837.1 - 0.026 14.1 2.1 0.76 9.4 0.2 3.5 4 0 0 4 4 4 0 Kelch motif OmpH PF03938.14 ETO18838.1 - 0.018 15.3 1.9 0.026 14.9 1.9 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Dynein_C PF18199.1 ETO18838.1 - 0.019 14.2 2.1 0.024 13.9 2.1 1.1 1 0 0 1 1 1 0 Dynein heavy chain C-terminal domain End3 PF12761.7 ETO18838.1 - 0.022 15.0 3.5 0.029 14.5 3.5 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 IL3 PF02059.15 ETO18838.1 - 0.14 12.3 4.8 0.18 11.9 4.2 1.4 1 1 0 1 1 1 0 Interleukin-3 Ras PF00071.22 ETO18840.1 - 3.3e-07 30.0 1.4 0.0044 16.6 0.0 3.3 2 1 0 3 3 3 3 Ras family GTP_EFTU PF00009.27 ETO18840.1 - 0.87 9.1 6.7 4.7 6.7 6.7 2.3 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Phtf-FEM1B_bdg PF12129.8 ETO18842.1 - 0.043 13.6 0.1 0.043 13.6 0.1 1.8 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor CHASE5 PF17149.4 ETO18842.1 - 0.08 12.9 0.1 0.19 11.7 0.1 1.5 1 0 0 1 1 1 0 Periplasmic sensor domain found in signal transduction proteins SNARE PF05739.19 ETO18843.1 - 2e-19 69.3 0.4 2e-19 69.3 0.4 2.0 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ETO18843.1 - 2.2e-14 53.6 8.6 2.2e-14 53.6 8.6 1.8 1 1 1 2 2 2 1 Syntaxin ETRAMP PF09716.10 ETO18843.1 - 0.0011 18.9 1.5 0.0053 16.8 1.5 2.3 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) MCPsignal PF00015.21 ETO18843.1 - 0.0058 16.5 1.4 0.0058 16.5 1.4 2.3 2 0 0 2 2 2 1 Methyl-accepting chemotaxis protein (MCP) signalling domain Mod_r PF07200.13 ETO18843.1 - 0.012 15.8 19.4 0.019 15.1 5.3 3.1 2 1 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Laminin_II PF06009.12 ETO18843.1 - 0.051 13.6 0.3 0.051 13.6 0.3 3.2 1 1 1 3 3 3 0 Laminin Domain II Stk19 PF10494.9 ETO18843.1 - 0.061 13.0 2.3 0.099 12.3 2.3 1.3 1 0 0 1 1 1 0 Serine-threonine protein kinase 19 PMC2NT PF08066.12 ETO18843.1 - 0.063 14.0 0.5 0.063 14.0 0.5 3.0 2 1 1 3 3 3 0 PMC2NT (NUC016) domain Lge1 PF11488.8 ETO18843.1 - 0.13 12.5 13.9 0.044 14.0 2.3 3.1 2 1 0 2 2 2 0 Transcriptional regulatory protein LGE1 PIN_8 PF18476.1 ETO18843.1 - 0.17 11.7 14.1 0.12 12.2 6.1 2.0 1 1 1 2 2 2 0 PIN like domain COG2 PF06148.11 ETO18843.1 - 0.8 9.8 10.8 0.25 11.4 0.3 3.1 1 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 FliJ PF02050.16 ETO18843.1 - 3.2 8.0 20.9 0.16 12.2 2.4 3.2 2 1 0 2 2 2 0 Flagellar FliJ protein Rax2 PF12768.7 ETO18843.1 - 3.7 6.9 6.9 0.98 8.8 0.4 2.2 1 1 0 2 2 2 0 Cortical protein marker for cell polarity DUF3585 PF12130.8 ETO18843.1 - 4.1 7.6 11.1 1.2 9.2 4.8 2.8 2 1 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Muted PF14942.6 ETO18843.1 - 4.2 7.7 19.3 8.2 6.8 8.8 2.6 1 1 0 2 2 2 0 Organelle biogenesis, Muted-like protein WXG100 PF06013.12 ETO18843.1 - 4.6 7.6 13.1 4.6 7.5 2.6 3.6 2 2 0 2 2 2 0 Proteins of 100 residues with WXG DUF4175 PF13779.6 ETO18843.1 - 6 4.6 15.9 24 2.6 15.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4175) DUF1664 PF07889.12 ETO18843.1 - 6.2 6.9 12.0 9.1 6.3 1.5 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Ras PF00071.22 ETO18844.1 - 1.9e-09 37.4 0.3 2.5e-09 36.9 0.3 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETO18844.1 - 0.0018 17.8 0.2 0.0025 17.3 0.2 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family MeaB PF03308.16 ETO18844.1 - 0.057 12.4 0.1 0.065 12.2 0.1 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RGS PF00615.19 ETO18845.1 - 0.098 12.9 3.0 1.3 9.3 0.2 2.7 2 0 0 2 2 2 0 Regulator of G protein signaling domain DUF3377 PF11857.8 ETO18845.1 - 0.22 11.5 1.4 0.67 9.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) SR-25 PF10500.9 ETO18846.1 - 0.023 14.3 12.2 0.042 13.4 12.2 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dicty_REP PF05086.12 ETO18846.1 - 0.77 7.7 10.3 1 7.3 10.3 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4667 PF15700.5 ETO18846.1 - 1.7 8.7 28.7 0.065 13.3 22.5 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4667) MSP1_C PF07462.11 ETO18846.1 - 4.8 5.7 7.3 7.4 5.1 7.3 1.3 1 0 0 1 1 1 0 Merozoite surface protein 1 (MSP1) C-terminus ATP-synt_D PF01813.17 ETO18847.1 - 0.0031 17.4 8.1 0.0031 17.4 8.1 2.3 1 1 1 2 2 2 1 ATP synthase subunit D DUF664 PF04978.12 ETO18847.1 - 0.0068 16.8 1.0 0.0068 16.8 1.0 1.8 1 1 1 2 2 2 1 Protein of unknown function (DUF664) DUF4248 PF14053.6 ETO18847.1 - 0.16 12.0 3.7 0.39 10.8 0.7 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF4248) V_ATPase_I PF01496.19 ETO18847.1 - 0.31 8.9 19.6 0.38 8.6 19.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tai4 PF16695.5 ETO18847.1 - 1.1 9.8 11.1 3.7 8.1 1.9 2.8 1 1 2 3 3 3 0 Type VI secretion system (T6SS), amidase immunity protein Fibin PF15819.5 ETO18847.1 - 1.8 8.3 13.9 3.5 7.4 7.3 2.1 1 1 1 2 2 2 0 Fin bud initiation factor homologue ALMT PF11744.8 ETO18847.1 - 2.8 6.7 18.0 3.6 6.3 18.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter APG6_N PF17675.1 ETO18847.1 - 2.9 8.4 31.8 14 6.2 30.6 2.4 1 1 0 1 1 1 0 Apg6 coiled-coil region CTNNBL PF08216.11 ETO18847.1 - 7.4 6.8 16.6 8.6 6.6 4.3 3.0 2 1 1 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear NOA36 PF06524.12 ETO18848.1 - 0.21 10.9 18.3 0.29 10.4 18.3 1.3 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO18848.1 - 3.3 5.8 23.6 3.7 5.6 23.6 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO18848.1 - 3.9 6.1 10.9 4.6 5.9 10.9 1.2 1 0 0 1 1 1 0 Presenilin E7 PF00527.18 ETO18848.1 - 5.6 7.2 8.0 17 5.7 8.0 1.8 1 0 0 1 1 1 0 E7 protein, Early protein Pkinase PF00069.25 ETO18849.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein kinase domain WD40 PF00400.32 ETO18850.1 - 8.7e-05 23.2 1.5 0.00035 21.3 0.2 2.6 2 0 0 2 2 2 1 WD domain, G-beta repeat DHC_N1 PF08385.12 ETO18852.1 - 8.4e-110 368.0 6.0 8.4e-110 368.0 6.0 3.0 2 2 1 3 3 3 1 Dynein heavy chain, N-terminal region 1 DUF3437 PF11919.8 ETO18852.1 - 0.057 13.3 0.1 5.1 7.1 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) PABP PF00658.18 ETO18852.1 - 0.084 13.1 0.2 0.25 11.6 0.2 1.8 1 0 0 1 1 1 0 Poly-adenylate binding protein, unique domain WD40 PF00400.32 ETO18853.1 - 2.7e-40 135.6 13.6 7e-10 39.4 0.1 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18853.1 - 2e-19 69.7 1.6 1.5e-05 25.2 0.0 4.5 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO18853.1 - 5.5e-11 42.4 2.6 6.9e-06 25.6 0.1 3.3 1 1 2 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO18853.1 - 2.7e-06 27.4 0.1 0.02 14.8 0.0 2.4 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO18853.1 - 1.8e-05 23.6 0.5 0.18 10.4 0.1 3.4 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO18853.1 - 0.0035 17.4 2.5 0.82 9.8 0.2 3.2 1 1 0 2 2 2 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO18853.1 - 0.0042 16.7 0.0 0.02 14.5 0.0 2.0 1 1 0 1 1 1 1 PQQ-like domain Pentapeptide PF00805.22 ETO18853.1 - 0.0087 15.7 0.0 0.017 14.8 0.0 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Cytochrom_D1 PF02239.16 ETO18853.1 - 0.025 13.1 0.8 5.6 5.4 0.0 2.5 1 1 2 3 3 3 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO18853.1 - 0.055 13.4 0.1 1.3 9.0 0.0 2.7 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Sld3_N PF18523.1 ETO18853.1 - 0.31 11.2 1.9 0.42 10.7 0.5 2.0 2 0 0 2 2 2 0 Sld3 N-terminal domain Orf78 PF06024.12 ETO18854.1 - 0.12 12.7 0.1 0.12 12.7 0.1 2.5 2 1 0 2 2 2 0 Orf78 (ac78) Presenilin PF01080.17 ETO18855.1 - 1.4 7.6 6.8 1.5 7.5 6.8 1.1 1 0 0 1 1 1 0 Presenilin PDDEXK_6 PF04720.12 ETO18855.1 - 1.5 8.7 5.1 2.1 8.2 5.1 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Pox_Ag35 PF03286.14 ETO18855.1 - 4.2 7.1 8.6 0.2 11.4 3.1 1.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF1943 PF09172.11 ETO18856.1 - 0.0026 17.0 0.3 0.0044 16.3 0.3 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) Ion_trans PF00520.31 ETO18858.1 - 2.8e-46 157.8 27.2 3.3e-33 115.0 11.6 2.1 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 ETO18858.1 - 1.5e-05 23.9 12.6 5.9e-05 21.9 4.6 3.6 2 2 2 4 4 4 2 Polycystin cation channel NPCC PF08058.11 ETO18858.1 - 2.4 8.2 6.7 6.1 6.9 0.1 2.9 2 1 0 3 3 3 0 Nuclear pore complex component Ion_trans PF00520.31 ETO18859.1 - 1.1e-13 51.0 0.4 1.7e-13 50.4 0.4 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO18859.1 - 0.0075 15.0 0.2 0.012 14.3 0.2 1.2 1 0 0 1 1 1 1 Polycystin cation channel WD40 PF00400.32 ETO18860.1 - 5.4e-56 185.3 7.8 4e-09 37.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18860.1 - 4.5e-18 65.3 0.6 0.00069 19.9 0.1 6.6 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO18860.1 - 1.2e-16 60.6 0.5 0.0065 15.5 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO18860.1 - 1.4e-13 51.2 0.7 1.2e-05 25.3 0.1 2.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO18860.1 - 1.1e-09 38.0 0.1 0.0001 21.8 0.0 3.4 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO18860.1 - 9.7e-08 31.1 6.1 0.044 12.4 0.0 4.7 2 2 3 5 5 5 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO18860.1 - 3.5e-06 27.1 1.8 0.43 10.7 0.0 4.5 1 1 4 5 5 5 2 Family of unknown function (DUF5570) PD40 PF07676.12 ETO18860.1 - 1e-05 25.3 1.3 2.8 8.0 0.0 6.1 6 1 1 7 7 7 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO18860.1 - 0.0014 18.2 5.4 13 5.5 0.0 5.8 6 1 0 6 6 6 1 Proteasome subunit A N-terminal signature Nbas_N PF15492.6 ETO18860.1 - 0.0019 17.6 0.3 0.29 10.4 0.0 3.2 2 1 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal DUF3748 PF12566.8 ETO18860.1 - 0.062 13.2 0.1 4.3 7.3 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF3748) Kelch_6 PF13964.6 ETO18861.1 - 2.4e-08 34.0 1.4 0.0016 18.7 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ETO18861.1 - 0.00018 21.4 0.4 0.0021 18.0 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO18861.1 - 0.0028 17.6 4.0 0.024 14.6 0.2 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO18861.1 - 0.054 13.8 0.2 0.43 10.9 0.0 2.6 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO18861.1 - 0.17 11.5 2.9 9.5 5.9 0.1 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO18861.1 - 0.21 11.7 3.6 76 3.5 0.1 4.0 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO18862.1 - 1.3e-38 130.3 4.0 5.5e-09 36.5 0.0 6.9 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18862.1 - 9.8e-12 45.0 0.5 0.024 14.9 0.0 5.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO18862.1 - 3e-09 36.6 2.1 4.6e-06 26.2 0.7 3.2 2 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO18862.1 - 7.3e-06 25.2 0.3 0.42 9.5 0.0 4.0 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO18862.1 - 1.9e-05 24.6 0.5 0.76 9.6 0.1 3.2 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO18862.1 - 0.00063 18.5 4.5 0.95 8.0 0.1 3.8 2 1 1 4 4 4 3 Nucleoporin Nup120/160 CPSF_A PF03178.15 ETO18862.1 - 0.0074 15.6 0.2 0.016 14.5 0.2 1.6 1 1 0 1 1 1 1 CPSF A subunit region TPR_12 PF13424.6 ETO18863.1 - 4.8e-47 158.1 0.2 2.5e-15 56.5 0.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18863.1 - 1.6e-36 122.7 30.8 2.1e-08 33.6 1.5 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18863.1 - 6.6e-32 107.2 0.2 1.3e-05 24.9 0.0 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18863.1 - 7.8e-29 97.4 25.9 2.3e-08 33.6 0.7 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18863.1 - 8.9e-29 97.3 16.0 9.7e-07 28.5 0.4 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO18863.1 - 4.3e-26 90.0 0.0 5.8e-05 22.8 0.0 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18863.1 - 2.9e-16 58.8 22.6 1.4e-06 27.8 0.9 8.0 5 3 3 8 8 8 5 TPR repeat TPR_6 PF13174.6 ETO18863.1 - 2.6e-11 43.4 2.0 0.4 11.4 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO18863.1 - 4.3e-11 42.4 8.2 0.28 11.7 0.2 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18863.1 - 5.3e-10 39.3 0.0 0.1 13.5 0.0 5.4 6 0 0 6 6 5 1 Tetratricopeptide repeat MIT PF04212.18 ETO18863.1 - 1.3e-07 31.5 9.7 0.02 14.9 1.0 4.9 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO18863.1 - 4e-07 30.4 0.1 0.0038 17.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO18863.1 - 8.7e-06 26.3 0.0 0.37 11.5 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO18863.1 - 2.1e-05 24.0 0.0 0.0046 16.4 0.0 2.4 1 1 1 2 2 2 1 MalT-like TPR region SHNi-TPR PF10516.9 ETO18863.1 - 3.2e-05 23.3 1.3 0.017 14.6 0.1 3.9 4 0 0 4 4 4 1 SHNi-TPR PSII_BNR PF14870.6 ETO18863.1 - 0.016 14.5 0.1 0.034 13.4 0.1 1.5 1 0 0 1 1 1 0 Photosynthesis system II assembly factor YCF48 RPN7 PF10602.9 ETO18863.1 - 0.026 14.2 10.0 5.9 6.6 0.0 5.0 1 1 4 5 5 5 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 ETO18863.1 - 0.075 13.3 9.4 2.7 8.3 0.5 4.4 1 1 4 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Sel1 PF08238.12 ETO18863.1 - 0.11 13.2 6.3 1.8 9.4 0.3 3.9 4 0 0 4 4 3 0 Sel1 repeat TPR_3 PF07720.12 ETO18863.1 - 0.14 12.1 14.3 0.42 10.7 0.8 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat SR-25 PF10500.9 ETO18864.1 - 4.7 6.8 10.7 11 5.5 10.7 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein ribosomal_L24 PF17136.4 ETO18866.1 - 0.004 17.5 0.2 0.0081 16.5 0.2 1.5 1 0 0 1 1 1 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 TFIIF_alpha PF05793.12 ETO18866.1 - 0.006 15.2 18.5 0.0062 15.2 18.5 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 ETO18866.1 - 0.011 13.9 15.2 0.012 13.8 15.2 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO18866.1 - 0.012 14.0 13.4 0.012 13.9 13.4 1.0 1 0 0 1 1 1 0 CDC45-like protein CPSF100_C PF13299.6 ETO18866.1 - 0.016 15.4 4.5 0.017 15.3 4.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 ETO18866.1 - 0.017 15.0 9.8 0.017 14.9 9.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Afi1 PF07792.12 ETO18866.1 - 0.021 15.3 4.2 0.038 14.5 4.3 1.4 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Merozoite_SPAM PF07133.11 ETO18866.1 - 0.07 13.1 25.1 0.1 12.6 25.1 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CobT PF06213.12 ETO18866.1 - 0.12 11.8 15.5 0.15 11.5 15.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TLP-20 PF06088.11 ETO18866.1 - 0.13 12.2 6.2 0.17 11.8 6.2 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) EIIBC-GUT_N PF03612.14 ETO18866.1 - 0.28 10.9 3.9 0.33 10.7 3.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus RNA_pol_Rpc4 PF05132.14 ETO18866.1 - 0.29 11.5 6.1 0.35 11.3 6.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_11 PF13086.6 ETO18866.1 - 0.44 10.3 6.4 0.46 10.2 6.4 1.1 1 0 0 1 1 1 0 AAA domain NARP1 PF12569.8 ETO18866.1 - 0.45 9.4 10.9 0.53 9.1 10.9 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Zip PF02535.22 ETO18866.1 - 0.63 9.2 10.7 0.69 9.1 10.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 ETO18866.1 - 0.72 8.8 4.8 0.86 8.5 4.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO18866.1 - 0.8 8.4 8.9 0.8 8.4 8.9 1.1 1 0 0 1 1 1 0 Presenilin TRAP_alpha PF03896.16 ETO18866.1 - 0.82 8.8 7.3 0.94 8.6 7.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 ETO18866.1 - 0.85 9.5 14.1 1.2 9.1 14.1 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Sporozoite_P67 PF05642.11 ETO18866.1 - 1.6 6.7 6.4 1.5 6.8 6.4 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Connexin PF00029.19 ETO18866.1 - 1.8 8.3 9.5 2.2 8.0 9.5 1.2 1 0 0 1 1 1 0 Connexin Paf1 PF03985.13 ETO18866.1 - 2 7.3 22.6 2.4 7.1 22.6 1.1 1 0 0 1 1 1 0 Paf1 CLN3 PF02487.17 ETO18866.1 - 2.3 7.2 3.4 2.5 7.1 3.4 1.1 1 0 0 1 1 1 0 CLN3 protein HA2 PF04408.23 ETO18866.1 - 3.1 8.1 5.5 4.6 7.6 5.5 1.4 1 0 0 1 1 1 0 Helicase associated domain (HA2) Neur_chan_memb PF02932.16 ETO18866.1 - 3.3 7.7 4.2 3.4 7.7 4.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ferlin_C PF16165.5 ETO18866.1 - 4.2 7.3 8.4 6 6.8 8.4 1.2 1 0 0 1 1 1 0 Ferlin C-terminus RRN3 PF05327.11 ETO18866.1 - 4.9 5.6 10.0 5.4 5.4 10.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cytomega_UL84 PF06284.11 ETO18866.1 - 5.1 5.4 8.1 5.6 5.3 8.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein MDM10 PF12519.8 ETO18866.1 - 6 5.6 8.2 6.4 5.5 8.2 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 PTPRCAP PF15713.5 ETO18866.1 - 6 7.1 19.2 8.3 6.7 19.2 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated YqfQ PF14181.6 ETO18866.1 - 8.7 6.5 10.0 11 6.2 10.0 1.2 1 0 0 1 1 1 0 YqfQ-like protein Abhydrolase_1 PF00561.20 ETO18867.1 - 0.0024 17.5 1.6 0.27 10.8 0.1 2.1 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO18867.1 - 0.061 13.9 0.3 0.091 13.4 0.3 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF3408 PF11888.8 ETO18867.1 - 0.46 10.6 27.7 0.13 12.4 10.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Nop14 PF04147.12 ETO18867.1 - 1.5 7.0 26.8 1.8 6.7 26.8 1.0 1 0 0 1 1 1 0 Nop14-like family LAP1C PF05609.12 ETO18867.1 - 2.2 7.3 20.1 2.4 7.1 20.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) VHS PF00790.19 ETO18868.1 - 3.8e-11 43.0 5.0 1.6e-07 31.3 0.3 2.5 1 1 1 2 2 2 2 VHS domain Lyase_1 PF00206.20 ETO18869.1 - 0.048 13.0 0.1 0.06 12.7 0.1 1.1 1 0 0 1 1 1 0 Lyase GAT PF03127.14 ETO18869.1 - 0.091 13.1 0.2 0.27 11.6 0.0 1.7 2 0 0 2 2 2 0 GAT domain S6PP PF05116.13 ETO18871.1 - 5e-35 121.2 0.6 5.9e-20 71.8 0.0 3.0 1 1 1 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 ETO18871.1 - 1.1e-08 35.1 0.0 3.2e-07 30.4 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase P4Ha_N PF08336.11 ETO18871.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.1 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region P-mevalo_kinase PF04275.14 ETO18871.1 - 0.11 12.4 1.9 0.27 11.2 1.0 2.2 2 0 0 2 2 2 0 Phosphomevalonate kinase DnaT PF17948.1 ETO18871.1 - 2.1 8.1 8.0 1.1 9.0 5.4 1.9 2 0 0 2 2 2 0 DnaT DNA-binding domain RRM_5 PF13893.6 ETO18872.1 - 1.8e-22 79.2 0.2 5.2e-21 74.5 0.1 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO18872.1 - 7.8e-13 48.0 0.1 7e-08 32.2 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO18872.1 - 0.0011 18.8 0.0 0.3 11.0 0.0 2.4 2 0 0 2 2 2 2 Occluded RNA-recognition motif PHM7_cyt PF14703.6 ETO18872.1 - 0.098 12.9 0.0 3.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter RNA_bind PF08675.11 ETO18872.1 - 0.14 12.2 0.0 0.51 10.4 0.0 2.0 2 0 0 2 2 2 0 RNA binding domain ANAPC1 PF12859.7 ETO18872.1 - 1.1 9.8 4.1 0.71 10.4 0.5 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 1 H_PPase PF03030.16 ETO18873.1 - 1.5e-58 199.0 32.3 8.8e-24 84.1 5.5 4.1 3 1 1 4 4 4 4 Inorganic H+ pyrophosphatase Vfa1 PF08432.10 ETO18874.1 - 0.015 15.7 1.0 0.02 15.2 1.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 dDENN PF03455.19 ETO18875.1 - 1.8e-09 37.4 0.9 4.2e-09 36.3 0.9 1.6 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.6 ETO18876.1 - 0.00039 20.5 0.0 0.00066 19.8 0.0 1.4 1 0 0 1 1 1 1 PPR repeat family PPR_3 PF13812.6 ETO18876.1 - 0.13 12.3 0.0 0.28 11.3 0.0 1.5 1 0 0 1 1 1 0 Pentatricopeptide repeat domain FHIPEP PF00771.20 ETO18878.1 - 0.014 13.9 0.0 0.016 13.7 0.0 1.0 1 0 0 1 1 1 0 FHIPEP family YajC PF02699.15 ETO18878.1 - 0.029 14.3 1.6 0.029 14.3 1.6 2.1 2 0 0 2 2 2 0 Preprotein translocase subunit OATP PF03137.20 ETO18878.1 - 0.033 12.5 2.7 0.05 11.9 2.7 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF2615 PF11027.8 ETO18878.1 - 0.036 14.2 0.2 0.12 12.5 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) OAD_gamma PF04277.13 ETO18878.1 - 0.067 13.8 3.2 0.16 12.6 3.2 1.8 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Conotoxin PF02950.17 ETO18878.1 - 0.084 13.9 1.9 0.87 10.6 0.1 2.4 2 0 0 2 2 2 0 Conotoxin WBP-1 PF11669.8 ETO18878.1 - 0.15 12.7 0.2 0.15 12.7 0.2 2.0 1 1 1 2 2 2 0 WW domain-binding protein 1 PH_10 PF15411.6 ETO18878.1 - 0.46 10.7 5.3 0.79 10.0 5.3 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain RIC3 PF15361.6 ETO18878.1 - 1.6 9.1 7.5 2.5 8.5 6.9 1.7 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 O_anti_polymase PF01901.16 ETO18878.1 - 1.7 7.8 5.1 1 8.6 3.4 1.4 2 0 0 2 2 2 0 Putative O-antigen polymerase PRC2_HTH_1 PF18118.1 ETO18878.1 - 2.7 8.8 9.8 2.3 9.1 8.3 1.6 2 0 0 2 2 2 0 Polycomb repressive complex 2 tri-helical domain PI3K_1B_p101 PF10486.9 ETO18880.1 - 8.4e-05 20.6 0.5 0.085 10.6 0.5 2.2 2 0 0 2 2 2 2 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pacs-1 PF10254.9 ETO18880.1 - 0.0012 17.9 0.3 0.0023 17.0 0.0 1.6 2 0 0 2 2 2 1 PACS-1 cytosolic sorting protein Solute_trans_a PF03619.16 ETO18881.1 - 1.3e-23 83.9 7.3 1.7e-23 83.5 7.3 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF3895 PF13034.6 ETO18882.1 - 0.055 13.5 0.1 0.17 11.9 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3895) Cullin PF00888.22 ETO18883.1 - 8.6e-14 51.1 5.0 9.4e-14 50.9 5.0 1.0 1 0 0 1 1 1 1 Cullin family RR_TM4-6 PF06459.12 ETO18884.1 - 5.7 6.7 14.6 6.6 6.5 14.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF295 PF03478.18 ETO18886.1 - 0.12 11.9 0.1 1.7 8.3 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF295) DUF21 PF01595.20 ETO18887.1 - 1.5e-27 96.4 1.6 4.6e-23 81.8 2.8 2.3 2 0 0 2 2 2 2 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETO18887.1 - 0.00011 22.6 0.4 0.15 12.5 0.1 3.8 3 1 0 3 3 3 1 CBS domain ArAE_1 PF06081.11 ETO18887.1 - 0.007 16.5 0.6 0.021 15.0 0.6 1.8 1 0 0 1 1 1 1 Aromatic acid exporter family member 1 DUF21 PF01595.20 ETO18888.1 - 1.1e-15 57.8 4.3 9.3e-14 51.5 4.3 2.9 1 1 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETO18888.1 - 0.0004 20.8 0.9 0.56 10.7 0.3 3.3 2 1 0 2 2 2 2 CBS domain DUF5631 PF18645.1 ETO18888.1 - 0.13 12.6 0.1 0.3 11.5 0.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5631) ENTH PF01417.20 ETO18889.1 - 9.1e-17 61.3 0.0 1.1e-10 41.6 0.0 2.3 2 0 0 2 2 2 2 ENTH domain ANTH PF07651.16 ETO18889.1 - 0.00013 21.1 0.1 0.46 9.4 0.1 2.5 3 0 0 3 3 3 2 ANTH domain Gly-zipper_Omp PF13488.6 ETO18891.1 - 7.8e-13 48.2 104.2 0.0003 20.7 22.2 6.3 1 1 4 6 6 6 5 Glycine zipper Rick_17kDa_Anti PF05433.15 ETO18891.1 - 6.4e-06 25.9 110.0 0.01 15.7 13.8 7.1 2 1 2 4 4 4 1 Glycine zipper 2TM domain Gly-zipper_YMGG PF13441.6 ETO18891.1 - 0.00058 19.6 85.5 0.77 9.5 25.2 6.0 2 1 2 4 4 4 2 YMGG-like Gly-zipper TraT PF05818.12 ETO18891.1 - 0.0055 16.4 45.0 0.26 10.9 3.8 4.0 1 1 3 4 4 4 3 Enterobacterial TraT complement resistance protein Transgly_assoc PF04226.13 ETO18891.1 - 5.7 7.3 116.2 1e+02 3.3 2.2 8.3 2 1 3 5 5 5 0 Transglycosylase associated protein ATP_sub_h PF10775.9 ETO18892.1 - 0.02 14.8 0.2 0.73 9.9 0.0 2.4 2 0 0 2 2 2 0 ATP synthase complex subunit h DUF4715 PF15835.5 ETO18892.1 - 0.14 12.3 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4715) DUF3439 PF11921.8 ETO18893.1 - 6.6e-05 22.9 1.9 0.00016 21.6 1.9 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Glyco_hydro2_C5 PF18565.1 ETO18893.1 - 0.11 12.4 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 Glycoside hydrolase family 2 C-terminal domain 5 DUF2683 PF10884.8 ETO18894.1 - 0.15 12.3 1.9 1 9.7 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2683) WD40 PF00400.32 ETO18895.1 - 4.5e-12 46.3 5.3 1.5e-06 28.8 1.1 3.0 2 0 0 2 2 2 2 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO18895.1 - 0.00011 22.8 5.7 0.00011 22.8 5.7 3.5 3 1 1 4 4 4 1 TRAF-type zinc finger zf-RING-like PF08746.11 ETO18895.1 - 0.07 13.4 1.2 1 9.7 1.2 2.8 1 1 0 1 1 1 0 RING-like domain zf-C3HC4_2 PF13923.6 ETO18895.1 - 3.8 7.4 8.2 3.5 7.5 5.3 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CENP-B_dimeris PF09026.10 ETO18896.1 - 1.3 9.5 13.9 4.2 7.8 8.3 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CDC45 PF02724.14 ETO18896.1 - 3.2 5.9 25.4 3.9 5.7 25.4 1.1 1 0 0 1 1 1 0 CDC45-like protein RelA_SpoT PF04607.17 ETO18897.1 - 0.27 11.5 6.1 0.051 13.8 2.0 1.8 2 0 0 2 2 2 0 Region found in RelA / SpoT proteins SelB-wing_3 PF09107.11 ETO18897.1 - 0.44 10.2 3.7 1.2 8.8 0.6 2.3 2 0 0 2 2 2 0 Elongation factor SelB, winged helix Secretin_N_2 PF07655.13 ETO18897.1 - 0.78 10.3 9.4 2.5 8.7 9.4 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain DUF1388 PF07142.12 ETO18898.1 - 1.1 9.3 3.7 0.6 10.1 0.2 2.3 3 0 0 3 3 3 0 Repeat of unknown function (DUF1388) zf-Di19 PF05605.12 ETO18899.1 - 0.0015 18.8 5.4 0.0035 17.6 5.4 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2 PF00096.26 ETO18899.1 - 0.0029 18.0 4.8 0.0029 18.0 4.8 2.5 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO18899.1 - 0.024 15.5 4.2 0.024 15.5 4.2 2.8 2 0 0 2 2 2 0 C2H2-type zinc finger DUF4637 PF15470.6 ETO18899.1 - 0.29 10.9 7.5 0.39 10.4 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) zf-C2H2_2 PF12756.7 ETO18899.1 - 0.35 11.2 9.7 0.34 11.2 7.5 2.3 1 1 0 1 1 1 0 C2H2 type zinc-finger (2 copies) zf-C2H2_9 PF16293.5 ETO18899.1 - 2.8 7.9 12.1 2.1 8.2 2.9 2.9 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Peptidase_S9_N PF02897.15 ETO18900.1 - 1.2e-37 129.7 0.1 1.4e-37 129.5 0.1 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain SET PF00856.28 ETO18901.1 - 2.6e-11 44.2 0.1 5.6e-10 39.9 0.1 2.2 1 1 0 1 1 1 1 SET domain AWS PF17907.1 ETO18901.1 - 9.9e-08 31.9 17.5 9.9e-08 31.9 17.5 2.7 2 1 0 2 2 2 1 AWS domain SET PF00856.28 ETO18902.1 - 0.0015 18.9 0.0 0.0033 17.8 0.0 1.5 1 0 0 1 1 1 1 SET domain RRM_1 PF00076.22 ETO18904.1 - 0.008 16.0 0.0 0.025 14.4 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Furin-like_2 PF15913.5 ETO18904.1 - 0.057 13.6 0.5 0.11 12.7 0.5 1.4 1 0 0 1 1 1 0 Furin-like repeat, cysteine-rich WD40 PF00400.32 ETO18905.1 - 5.3e-88 286.6 44.8 2.4e-10 40.8 0.2 12.7 12 0 0 12 12 12 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18905.1 - 2.7e-30 104.5 5.8 0.00079 19.7 0.1 9.8 1 1 10 11 11 11 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO18905.1 - 9e-20 70.9 16.4 0.0002 20.5 0.8 9.8 2 1 7 9 9 9 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO18905.1 - 7.3e-11 41.7 8.3 1.6 8.8 0.0 9.4 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat NACHT PF05729.12 ETO18905.1 - 2.7e-08 33.9 0.0 5.6e-08 32.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Nbas_N PF15492.6 ETO18905.1 - 1.9e-06 27.4 6.5 1.4 8.2 0.0 6.5 2 1 3 6 6 6 2 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO18905.1 - 0.00015 21.5 0.5 0.1 12.2 0.4 3.5 1 1 2 3 3 3 2 PQQ-like domain AAA_22 PF13401.6 ETO18905.1 - 0.0049 17.1 0.0 0.017 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain Gmad1 PF10647.9 ETO18905.1 - 0.006 16.4 0.0 23 4.6 0.0 4.6 1 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain AAA_18 PF13238.6 ETO18905.1 - 0.0083 16.7 0.0 0.0083 16.7 0.0 4.7 6 0 0 6 6 4 1 AAA domain RNA_helicase PF00910.22 ETO18905.1 - 0.011 16.1 0.1 0.092 13.2 0.0 2.7 1 1 0 1 1 1 0 RNA helicase SGL PF08450.12 ETO18905.1 - 0.013 15.1 0.3 12 5.4 0.2 3.4 1 1 2 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region RsgA_GTPase PF03193.16 ETO18905.1 - 0.036 14.0 4.0 0.078 12.9 0.6 2.9 2 0 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ETO18905.1 - 0.048 14.0 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Big_7 PF17957.1 ETO18905.1 - 0.1 13.4 9.0 37 5.2 0.2 5.7 6 1 0 6 6 5 0 Bacterial Ig domain DUF5570 PF17731.1 ETO18905.1 - 0.46 10.6 11.0 28 4.8 0.0 6.2 3 2 3 7 7 7 0 Family of unknown function (DUF5570) Sirohm_synth_C PF14823.6 ETO18907.1 - 0.035 13.7 0.0 0.12 12.0 0.0 1.9 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal GYF_2 PF14237.6 ETO18908.1 - 3.7e-07 29.8 0.1 0.0066 16.2 0.0 3.0 3 0 0 3 3 3 2 GYF domain 2 RGS PF00615.19 ETO18909.1 - 0.016 15.5 1.2 0.027 14.7 0.1 2.0 2 0 0 2 2 2 0 Regulator of G protein signaling domain CPSF100_C PF13299.6 ETO18909.1 - 0.16 12.1 8.1 1.4 9.1 0.4 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CCDC106 PF15794.5 ETO18909.1 - 0.51 10.0 13.0 0.047 13.4 2.6 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Peptidase_U57 PF05582.12 ETO18909.1 - 2.8 7.1 9.0 6.6 5.9 1.4 2.2 2 0 0 2 2 2 0 YabG peptidase U57 Androgen_recep PF02166.16 ETO18909.1 - 3 6.6 14.7 4.3 6.1 14.7 1.2 1 0 0 1 1 1 0 Androgen receptor DUF3391 PF11871.8 ETO18909.1 - 4.7 7.8 11.7 1.5 9.4 4.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3391) RR_TM4-6 PF06459.12 ETO18909.1 - 7.6 6.3 16.4 6.7 6.5 3.2 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 CodY PF06018.14 ETO18910.1 - 0.0013 18.3 1.1 0.0022 17.5 1.1 1.4 1 0 0 1 1 1 1 CodY GAF-like domain RPN2_C PF18004.1 ETO18910.1 - 0.0015 18.5 3.8 0.002 18.1 3.8 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain PDCD7 PF16021.5 ETO18910.1 - 0.0015 17.7 1.8 0.0022 17.2 1.8 1.1 1 0 0 1 1 1 1 Programmed cell death protein 7 Myc_N PF01056.18 ETO18910.1 - 0.0037 17.2 1.8 0.0044 17.0 1.8 1.1 1 0 0 1 1 1 1 Myc amino-terminal region Gti1_Pac2 PF09729.9 ETO18910.1 - 0.0082 16.2 3.0 0.013 15.6 3.0 1.3 1 0 0 1 1 1 1 Gti1/Pac2 family p450 PF00067.22 ETO18910.1 - 0.023 13.4 1.0 0.029 13.1 1.0 1.1 1 0 0 1 1 1 0 Cytochrome P450 CLN3 PF02487.17 ETO18910.1 - 0.027 13.5 0.3 0.036 13.1 0.3 1.3 1 0 0 1 1 1 0 CLN3 protein DUF4746 PF15928.5 ETO18910.1 - 0.046 13.2 6.0 0.063 12.7 6.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Polyoma_coat2 PF00761.20 ETO18910.1 - 0.059 13.1 3.3 0.081 12.6 3.3 1.1 1 0 0 1 1 1 0 Polyomavirus coat protein NPR3 PF03666.13 ETO18910.1 - 0.072 11.9 5.6 0.089 11.6 5.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO18910.1 - 0.098 11.4 4.7 0.12 11.1 4.7 1.1 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 ETO18910.1 - 0.12 12.9 9.7 0.18 12.3 9.7 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 ETO18910.1 - 0.21 10.8 4.5 0.26 10.5 4.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter V_ATPase_I PF01496.19 ETO18910.1 - 0.28 9.0 7.4 0.37 8.7 7.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 ETO18910.1 - 0.31 10.8 4.1 0.42 10.3 4.1 1.2 1 0 0 1 1 1 0 Connexin CSRNP_N PF16019.5 ETO18910.1 - 0.49 10.3 7.7 0.72 9.7 7.7 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Pox_Ag35 PF03286.14 ETO18910.1 - 0.69 9.7 11.0 1 9.1 11.0 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM176 PF14851.6 ETO18910.1 - 0.73 9.5 8.4 1.4 8.6 8.4 1.4 1 0 0 1 1 1 0 FAM176 family Methyltransf_12 PF08242.12 ETO18910.1 - 1 10.2 3.3 2.4 9.0 3.3 1.7 1 0 0 1 1 1 0 Methyltransferase domain DUF4820 PF16091.5 ETO18910.1 - 1.6 8.1 6.8 2.4 7.5 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) O-antigen_lig PF13425.6 ETO18910.1 - 1.7 7.4 8.8 2.3 6.9 8.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF4834 PF16118.5 ETO18910.1 - 3 8.9 9.0 5.3 8.1 9.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Rib_recp_KP_reg PF05104.12 ETO18910.1 - 3.1 8.8 8.1 4.8 8.2 8.1 1.2 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region NOA36 PF06524.12 ETO18910.1 - 4.5 6.5 15.0 6.8 5.9 15.0 1.2 1 0 0 1 1 1 0 NOA36 protein ALMT PF11744.8 ETO18910.1 - 4.7 5.9 7.0 6.1 5.6 7.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DNA_pol_phi PF04931.13 ETO18910.1 - 8.1 4.4 10.7 10 4.0 10.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-C2H2_8 PF15909.5 ETO18911.1 - 6.2e-05 23.2 2.6 0.00013 22.2 2.6 1.6 1 0 0 1 1 1 1 C2H2-type zinc ribbon zf-C2H2 PF00096.26 ETO18911.1 - 0.0001 22.6 7.2 0.092 13.2 0.2 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO18911.1 - 0.00051 20.7 9.0 0.19 12.7 4.2 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger FOXP-CC PF16159.5 ETO18911.1 - 0.0089 16.6 5.1 0.8 10.4 0.2 2.6 1 1 1 2 2 2 2 FOXP coiled-coil domain PyrI_C PF02748.15 ETO18911.1 - 0.026 14.4 3.7 0.062 13.2 3.7 1.7 1 0 0 1 1 1 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-Di19 PF05605.12 ETO18911.1 - 0.028 14.7 10.9 0.19 12.1 3.3 2.6 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 ETO18911.1 - 0.23 12.0 8.6 0.23 11.9 4.6 2.7 2 0 0 2 2 2 0 Zinc-finger double domain Peptidase_M16_M PF16187.5 ETO18913.1 - 6.1e-28 97.9 0.2 3.1e-21 75.9 0.0 2.1 2 0 0 2 2 2 2 Middle or third domain of peptidase_M16 DUF4667 PF15700.5 ETO18913.1 - 0.015 15.4 13.2 0.021 14.9 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4667) SR-25 PF10500.9 ETO18913.1 - 0.027 14.1 14.6 0.037 13.6 14.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein MMU163 PF17119.5 ETO18913.1 - 0.035 13.3 1.5 0.05 12.7 1.5 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Macoilin PF09726.9 ETO18913.1 - 0.037 12.6 6.5 0.046 12.3 6.5 1.1 1 0 0 1 1 1 0 Macoilin family Pol_alpha_B_N PF08418.10 ETO18913.1 - 0.14 12.1 5.5 0.23 11.4 5.5 1.3 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal PAP1 PF08601.10 ETO18913.1 - 0.48 10.1 16.1 0.65 9.7 16.1 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 AF-4 PF05110.13 ETO18913.1 - 0.54 8.3 12.2 0.67 8.0 12.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein SOG2 PF10428.9 ETO18913.1 - 0.57 9.3 17.1 0.69 9.0 17.1 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Hamartin PF04388.12 ETO18913.1 - 1.5 7.4 10.7 1.8 7.1 10.7 1.1 1 0 0 1 1 1 0 Hamartin protein Dicty_REP PF05086.12 ETO18913.1 - 1.6 6.6 14.8 2.3 6.1 14.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4692 PF15763.5 ETO18913.1 - 1.8 9.0 17.0 15 6.0 14.2 2.1 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) Apt1 PF10351.9 ETO18913.1 - 2.1 7.1 6.6 2.6 6.8 6.6 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Atrophin-1 PF03154.15 ETO18913.1 - 5.3 5.2 11.4 6.6 4.9 11.4 1.0 1 0 0 1 1 1 0 Atrophin-1 family RAP1 PF07218.11 ETO18913.1 - 8.2 4.6 11.2 11 4.1 11.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) FAM199X PF15814.5 ETO18913.1 - 9.1 5.2 12.7 14 4.6 12.7 1.2 1 0 0 1 1 1 0 Protein family FAM199X Sec63 PF02889.16 ETO18915.1 - 0.12 11.6 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Sec63 Brl domain BPD_transp_2 PF02653.16 ETO18915.1 - 0.21 10.7 0.0 0.29 10.2 0.0 1.1 1 0 0 1 1 1 0 Branched-chain amino acid transport system / permease component Sec63 PF02889.16 ETO18916.1 - 4.8e-09 35.7 0.0 4.9e-09 35.7 0.0 1.1 1 0 0 1 1 1 1 Sec63 Brl domain VHS PF00790.19 ETO18918.1 - 3.9e-12 46.2 0.1 2.1e-11 43.9 0.1 2.3 1 0 0 1 1 1 1 VHS domain DUF1317 PF07026.11 ETO18919.1 - 0.071 12.9 0.0 0.15 11.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1317) CRIM PF16978.5 ETO18920.1 - 0.00026 21.1 3.6 0.00044 20.4 1.3 2.4 1 1 1 2 2 2 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain Type_III_YscX PF09474.10 ETO18921.1 - 0.015 15.6 1.7 0.028 14.7 1.7 1.4 1 0 0 1 1 1 0 Type III secretion system YscX (type_III_YscX) HrpB7 PF09486.10 ETO18921.1 - 0.016 15.6 3.7 0.016 15.6 3.7 2.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) IL4Ra_N PF09238.10 ETO18921.1 - 0.052 13.9 0.5 0.32 11.4 0.2 2.0 2 0 0 2 2 2 0 Interleukin-4 receptor alpha chain, N-terminal Spectrin PF00435.21 ETO18921.1 - 0.089 13.3 10.5 0.83 10.2 1.3 2.5 2 1 1 3 3 3 0 Spectrin repeat Exonuc_VII_L PF02601.15 ETO18921.1 - 0.14 11.7 4.3 0.15 11.6 4.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit OmpH PF03938.14 ETO18921.1 - 0.42 10.9 12.0 0.62 10.4 12.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Stathmin PF00836.19 ETO18921.1 - 2.2 8.2 15.6 1.1 9.2 13.3 1.6 2 0 0 2 2 2 0 Stathmin family RhoGAP PF00620.27 ETO18922.1 - 2.1e-09 37.4 0.5 1.7e-08 34.4 0.5 2.5 1 1 0 1 1 1 1 RhoGAP domain V_ATPase_I PF01496.19 ETO18923.1 - 0.11 10.4 2.3 0.13 10.2 2.3 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PheRS_DBD2 PF18554.1 ETO18923.1 - 1.6 8.8 7.3 0.29 11.1 3.1 2.0 2 0 0 2 2 2 0 PheRS DNA binding domain 2 Apc15p PF05841.11 ETO18923.1 - 3.2 8.6 11.4 6.3 7.6 11.4 1.5 1 0 0 1 1 1 0 Apc15p protein Folate_carrier PF01770.18 ETO18923.1 - 4.7 5.9 4.3 6.6 5.4 4.3 1.1 1 0 0 1 1 1 0 Reduced folate carrier Secretin_N_2 PF07655.13 ETO18923.1 - 4.7 7.8 18.1 0.24 11.9 11.6 2.2 3 0 0 3 3 3 0 Secretin N-terminal domain GCP_C_terminal PF04130.13 ETO18924.1 - 0.0048 16.4 0.3 0.01 15.3 0.3 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Hum_adeno_E3A PF05393.11 ETO18924.1 - 0.14 12.2 0.1 0.73 9.8 0.0 2.2 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein zf-4CXXC_R1 PF10497.9 ETO18925.1 - 2.1e-07 31.1 19.3 2.1e-07 31.1 19.3 2.0 2 1 0 2 2 2 1 Zinc-finger domain of monoamine-oxidase A repressor R1 Hydrolase_4 PF12146.8 ETO18926.1 - 6.6e-09 35.4 0.0 2.7e-07 30.1 0.0 2.6 2 1 0 2 2 2 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO18926.1 - 0.0001 22.0 0.2 0.39 10.3 0.1 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold VirJ PF06057.11 ETO18926.1 - 0.066 13.1 0.0 0.84 9.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial virulence protein (VirJ) YqcI_YcgG PF08892.11 ETO18927.1 - 0.0078 16.1 1.4 0.012 15.4 1.4 1.2 1 0 0 1 1 1 1 YqcI/YcgG family RVT_1 PF00078.27 ETO18928.1 - 6.8e-07 29.0 1.9 0.002 17.7 0.1 3.7 2 2 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) MFS_Mycoplasma PF07672.13 ETO18928.1 - 0.001 18.4 0.3 0.0018 17.6 0.3 1.3 1 0 0 1 1 1 1 Mycoplasma MFS transporter DUF4405 PF14358.6 ETO18929.1 - 0.57 10.8 4.9 1.2 9.7 4.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4405) ASFV_J13L PF05568.11 ETO18929.1 - 0.73 9.6 4.3 2 8.1 4.3 1.7 1 0 0 1 1 1 0 African swine fever virus J13L protein IncF PF17626.2 ETO18930.1 - 0.12 12.7 0.6 0.12 12.7 0.6 1.7 2 0 0 2 2 2 0 Inclusion membrane protein F Chorion_2 PF03964.15 ETO18932.1 - 1.3 9.9 27.3 0.93 10.4 3.0 3.0 2 1 1 3 3 3 0 Chorion family 2 Ank_4 PF13637.6 ETO18933.1 - 0.039 14.5 0.0 2.7 8.7 0.0 2.4 1 1 1 2 2 2 0 Ankyrin repeats (many copies) PX PF00787.24 ETO18934.1 - 4.5e-20 71.7 0.7 1.1e-19 70.5 0.0 2.0 3 0 0 3 3 3 1 PX domain Vps5 PF09325.10 ETO18934.1 - 0.17 11.4 13.2 0.1 12.2 4.2 2.6 2 1 1 3 3 3 0 Vps5 C terminal like DegS PF05384.11 ETO18934.1 - 0.17 11.4 3.8 4.3 6.8 0.0 3.1 3 0 0 3 3 3 0 Sensor protein DegS APG6_N PF17675.1 ETO18934.1 - 0.29 11.7 6.9 0.85 10.1 0.2 2.6 1 1 0 2 2 2 0 Apg6 coiled-coil region Muted PF14942.6 ETO18934.1 - 3 8.2 12.2 5.7 7.3 0.5 3.2 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein XhlA PF10779.9 ETO18934.1 - 3.9 7.8 6.2 3.6 7.9 3.3 2.5 2 0 0 2 2 2 0 Haemolysin XhlA Occludin_ELL PF07303.13 ETO18935.1 - 0.00026 21.7 13.3 0.0085 16.8 3.1 3.6 3 1 0 3 3 3 2 Occludin homology domain GAS PF13851.6 ETO18935.1 - 0.051 12.9 25.1 0.21 10.9 8.7 2.5 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding Glyco_hydr_30_2 PF14587.6 ETO18935.1 - 0.07 12.7 5.5 0.13 11.9 5.5 1.5 1 0 0 1 1 1 0 O-Glycosyl hydrolase family 30 SlyX PF04102.12 ETO18935.1 - 0.079 13.6 11.9 1.6 9.4 0.9 3.6 3 0 0 3 3 3 0 SlyX NpwBP PF12622.7 ETO18935.1 - 0.23 12.3 3.9 0.55 11.0 2.3 2.5 2 0 0 2 2 2 0 mRNA biogenesis factor Cep57_CLD_2 PF14197.6 ETO18935.1 - 0.25 11.5 11.1 0.51 10.5 0.5 3.2 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 DUF4407 PF14362.6 ETO18935.1 - 0.8 9.0 18.7 0.64 9.3 15.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 ETO18935.1 - 1 9.6 33.2 0.24 11.6 9.7 3.3 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) FlaC_arch PF05377.11 ETO18935.1 - 1.3 9.4 15.3 0.52 10.7 0.6 4.5 4 2 1 5 5 5 0 Flagella accessory protein C (FlaC) Spc24 PF08286.11 ETO18935.1 - 1.6 9.0 21.4 6.8 7.0 1.4 4.3 4 0 0 4 4 4 0 Spc24 subunit of Ndc80 Fib_alpha PF08702.10 ETO18935.1 - 2.5 8.3 21.3 8.4 6.6 5.6 3.5 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family DUF3450 PF11932.8 ETO18935.1 - 2.6 7.3 20.0 0.5 9.6 11.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF4140 PF13600.6 ETO18935.1 - 3.4 8.2 11.3 5.5 7.5 1.5 3.4 3 0 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) CENP-F_leu_zip PF10473.9 ETO18935.1 - 3.7 7.6 31.4 0.12 12.4 11.2 3.1 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Tropomyosin_1 PF12718.7 ETO18935.1 - 3.9 7.6 35.6 0.2 11.8 10.4 3.0 2 1 1 3 3 3 0 Tropomyosin like DivIC PF04977.15 ETO18935.1 - 4.9 7.0 25.2 0.055 13.2 1.1 3.6 4 0 0 4 4 4 0 Septum formation initiator DUF5357 PF17310.2 ETO18935.1 - 5.4 5.5 9.7 0.14 10.6 2.6 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5357) TLD PF07534.16 ETO18936.1 - 4e-15 56.3 0.5 8.1e-15 55.3 0.5 1.5 1 0 0 1 1 1 1 TLD fn3 PF00041.21 ETO18936.1 - 0.032 14.6 0.1 0.071 13.5 0.0 1.6 2 0 0 2 2 2 0 Fibronectin type III domain zf-CCHC_2 PF13696.6 ETO18937.1 - 1.5e-12 47.1 51.3 1.1e-06 28.4 10.8 4.0 4 0 0 4 4 4 3 Zinc knuckle zf-CCHC PF00098.23 ETO18937.1 - 3.7e-10 39.4 26.9 0.0022 18.0 5.1 3.4 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 ETO18937.1 - 9.7e-06 25.5 21.9 0.023 14.7 1.4 3.6 1 1 2 3 3 3 3 Zinc knuckle zf-CCHC_4 PF14392.6 ETO18937.1 - 4.1 7.2 21.3 2 8.2 0.3 3.5 3 0 0 3 3 3 0 Zinc knuckle RhoGEF PF00621.20 ETO18938.1 - 2.5e-17 63.7 2.0 4e-17 63.0 2.0 1.3 1 0 0 1 1 1 1 RhoGEF domain FYVE PF01363.21 ETO18938.1 - 1.1e-06 28.7 0.8 2.4e-06 27.6 0.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger La PF05383.17 ETO18939.1 - 5.3e-09 36.0 0.0 1.6e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ETO18939.1 - 0.00029 20.6 0.0 0.88 9.4 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ETO18939.1 - 0.0055 17.0 0.1 3.7 7.7 0.0 2.5 2 0 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter C_Hendra PF16821.5 ETO18939.1 - 0.011 15.6 0.6 0.029 14.3 0.6 1.7 1 0 0 1 1 1 0 C protein from hendra and measles viruses Secretin_N_2 PF07655.13 ETO18939.1 - 9.8 6.8 50.4 3.7 8.1 2.5 3.4 3 0 0 3 3 3 0 Secretin N-terminal domain STAS PF01740.21 ETO18940.1 - 1.4e-19 69.8 0.1 2.5e-19 69.0 0.1 1.4 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO18940.1 - 7e-17 61.3 0.3 1.1e-16 60.6 0.3 1.3 1 0 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 ETO18940.1 - 0.026 14.9 2.9 0.026 14.9 2.9 1.7 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily DUF4120 PF13496.6 ETO18942.1 - 0.0096 16.3 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4120) Peptidase_C14 PF00656.22 ETO18943.1 - 7.3e-06 26.1 0.3 2.8e-05 24.2 0.3 2.0 1 1 0 1 1 1 1 Caspase domain TPR_12 PF13424.6 ETO18944.1 - 2.1e-38 130.5 5.9 1.9e-12 47.3 0.1 3.2 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO18944.1 - 2.3e-22 78.1 0.1 8.1e-06 25.5 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO18944.1 - 3.2e-21 73.7 0.5 9.1e-07 28.5 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO18944.1 - 2.1e-19 68.0 14.3 1.1e-05 25.2 0.0 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO18944.1 - 5.6e-16 57.6 15.1 3.7e-06 26.5 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO18944.1 - 1.1e-13 50.1 10.3 0.0037 17.3 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO18944.1 - 4.1e-10 39.3 1.5 0.019 15.3 0.0 3.8 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18944.1 - 0.00079 19.1 14.3 0.38 10.5 0.0 5.1 5 1 1 6 6 6 3 TPR repeat TPR_14 PF13428.6 ETO18944.1 - 0.0029 18.3 0.0 24 6.1 0.0 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO18944.1 - 0.0043 17.6 0.2 43 5.1 0.0 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO18944.1 - 0.0078 16.8 0.0 48 4.7 0.0 3.7 3 1 1 4 4 4 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO18944.1 - 0.014 15.2 2.8 0.075 12.7 0.5 2.3 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Lyase_1 PF00206.20 ETO18945.1 - 1.3e-06 28.0 0.0 1.6e-06 27.8 0.0 1.1 1 0 0 1 1 1 1 Lyase Lipl32 PF12103.8 ETO18945.1 - 0.063 12.9 0.0 0.081 12.6 0.0 1.2 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order DUF1072 PF06380.11 ETO18946.1 - 0.061 13.2 0.1 0.061 13.2 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF1072) Herpes_LMP1 PF05297.11 ETO18946.1 - 7.8 5.6 14.5 11 5.1 14.5 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Trypan_PARP PF05887.11 ETO18947.1 - 0.0013 18.8 3.3 0.0021 18.1 3.3 1.3 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Prd1-P2 PF09214.11 ETO18947.1 - 0.0019 17.0 0.7 0.0019 17.0 0.7 1.5 2 0 0 2 2 2 1 Bacteriophage Prd1, adsorption protein P2 SRPRB PF09439.10 ETO18950.1 - 2.3e-15 56.5 0.2 5.5e-13 48.7 0.1 2.4 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Roc PF08477.13 ETO18950.1 - 0.00037 20.7 0.0 0.00077 19.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO18950.1 - 0.0091 15.5 0.0 0.018 14.5 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family ArAE_1 PF06081.11 ETO18950.1 - 0.037 14.2 2.0 0.037 14.2 2.0 2.5 3 0 0 3 3 3 0 Aromatic acid exporter family member 1 GTP_EFTU PF00009.27 ETO18950.1 - 0.046 13.3 0.0 0.25 10.8 0.0 2.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Dynamin_N PF00350.23 ETO18950.1 - 0.061 13.4 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 Dynamin family Septin PF00735.18 ETO18950.1 - 0.097 11.9 0.0 0.14 11.4 0.0 1.2 1 0 0 1 1 1 0 Septin DUF829 PF05705.14 ETO18951.1 - 1.9e-32 113.1 0.2 2.9e-32 112.5 0.2 1.2 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF829) Hydrolase_4 PF12146.8 ETO18951.1 - 0.053 12.8 0.0 0.1 11.9 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 F-box-like PF12937.7 ETO18952.1 - 0.0012 18.6 0.6 0.0018 18.1 0.6 1.2 1 0 0 1 1 1 1 F-box-like zf-C2H2 PF00096.26 ETO18953.1 - 6.4e-07 29.5 8.4 0.0071 16.7 0.4 2.6 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO18953.1 - 0.00015 22.1 2.8 0.00015 22.1 2.8 3.2 3 0 0 3 3 3 1 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO18953.1 - 0.00025 21.6 9.4 0.012 16.4 0.3 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ETO18953.1 - 0.00066 19.4 0.2 0.00066 19.4 0.2 2.4 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ETO18953.1 - 1 9.7 8.5 1.2 9.5 0.6 2.9 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ETO18953.1 - 1.6 8.8 8.7 6.2 6.9 1.4 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HE PF16278.5 ETO18953.1 - 9.1 6.8 8.6 6 7.4 0.4 3.3 1 1 1 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger RPEL PF02755.15 ETO18954.1 - 0.093 12.5 1.0 0.23 11.2 1.0 1.7 1 0 0 1 1 1 0 RPEL repeat VPS13_mid_rpt PF16910.5 ETO18955.1 - 0.0005 19.6 5.0 0.0085 15.5 0.0 4.1 4 1 0 4 4 4 2 Repeating coiled region of VPS13 ID PF18543.1 ETO18955.1 - 0.05 13.6 0.1 1.3 9.1 0.0 2.7 2 0 0 2 2 2 0 Intracellular delivery domain HMG14_17 PF01101.18 ETO18956.1 - 0.015 16.3 11.1 2.7 9.0 9.9 2.2 2 0 0 2 2 2 0 HMG14 and HMG17 CBM27 PF09212.10 ETO18956.1 - 0.062 13.5 0.1 0.13 12.5 0.1 1.5 1 0 0 1 1 1 0 Carbohydrate binding module 27 OAD_gamma PF04277.13 ETO18957.1 - 8.2 7.1 5.2 16 6.1 0.2 2.6 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain WD40 PF00400.32 ETO18958.1 - 8.6e-30 102.4 22.2 1e-07 32.5 0.6 6.5 5 2 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18958.1 - 1.1e-10 41.7 1.8 0.039 14.3 0.0 5.9 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18958.1 - 3e-10 39.4 2.9 0.23 10.0 0.0 5.0 2 1 3 5 5 5 4 Nucleoporin Nup120/160 PPR_3 PF13812.6 ETO18959.1 - 0.55 10.3 5.1 0.52 10.4 1.1 2.4 1 1 1 2 2 2 0 Pentatricopeptide repeat domain Arm PF00514.23 ETO18960.1 - 1.2e-15 57.0 2.0 0.0017 18.3 0.0 8.3 10 1 0 10 10 10 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO18960.1 - 3.7e-07 30.5 0.0 0.0014 19.1 0.0 4.3 4 0 0 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 ETO18960.1 - 2.3e-06 27.7 1.8 0.077 13.0 0.0 3.6 2 1 1 3 3 3 2 non-SMC mitotic condensation complex subunit 1 Arm_2 PF04826.13 ETO18960.1 - 0.00022 20.7 0.6 0.059 12.8 0.2 3.2 2 1 1 3 3 3 1 Armadillo-like HEAT PF02985.22 ETO18960.1 - 0.00076 19.5 0.2 3 8.4 0.0 4.9 5 0 0 5 5 5 1 HEAT repeat HEAT_2 PF13646.6 ETO18960.1 - 0.0012 19.1 0.0 1.1 9.6 0.0 3.4 2 1 0 2 2 2 2 HEAT repeats Arm_3 PF16186.5 ETO18960.1 - 0.08 12.5 2.7 5.5 6.6 0.3 3.1 2 1 0 2 2 2 0 Atypical Arm repeat WD40 PF00400.32 ETO18961.1 - 5.8e-33 112.4 26.1 1.2e-07 32.3 0.1 6.2 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO18961.1 - 3.2e-09 37.0 0.1 0.0035 17.6 0.0 4.2 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO18961.1 - 2.5e-07 29.8 3.5 0.96 8.0 0.0 4.8 2 1 3 5 5 5 4 Nucleoporin Nup120/160 DUF851 PF05867.11 ETO18961.1 - 0.034 13.6 0.1 2.1 7.8 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF851) AAA PF00004.29 ETO18962.1 - 8.8e-41 139.4 0.0 1.5e-40 138.7 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO18962.1 - 8.4e-07 29.5 0.2 0.00018 21.9 0.0 2.3 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ETO18962.1 - 6.7e-06 25.9 0.0 4.8e-05 23.2 0.0 2.1 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_2 PF07724.14 ETO18962.1 - 3.9e-05 23.8 0.0 9.3e-05 22.6 0.0 1.5 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO18962.1 - 4.3e-05 23.8 0.4 0.0077 16.5 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO18962.1 - 7e-05 22.8 0.0 0.00038 20.5 0.0 2.2 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_lid_3 PF17862.1 ETO18962.1 - 0.00019 21.2 0.1 0.00044 20.0 0.1 1.6 1 0 0 1 1 1 1 AAA+ lid domain DUF815 PF05673.13 ETO18962.1 - 0.00097 18.4 0.0 0.0015 17.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Prot_ATP_ID_OB PF16450.5 ETO18962.1 - 0.0015 18.5 0.1 0.0032 17.4 0.1 1.5 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain Mg_chelatase PF01078.21 ETO18962.1 - 0.0074 15.7 0.0 0.019 14.4 0.0 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO18962.1 - 0.0092 15.7 0.0 0.065 12.9 0.0 2.1 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_33 PF13671.6 ETO18962.1 - 0.0097 16.1 0.0 0.024 14.8 0.0 1.9 1 1 0 1 1 1 1 AAA domain AAA_24 PF13479.6 ETO18962.1 - 0.013 15.2 0.1 0.028 14.1 0.1 1.6 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETO18962.1 - 0.014 15.1 0.0 0.028 14.2 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ETO18962.1 - 0.02 15.3 0.0 0.04 14.3 0.0 1.5 1 0 0 1 1 1 0 RNA helicase AAA_7 PF12775.7 ETO18962.1 - 0.022 14.3 0.0 0.062 12.8 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region PhoH PF02562.16 ETO18962.1 - 0.03 13.8 0.0 0.14 11.6 0.0 1.9 2 0 0 2 2 2 0 PhoH-like protein TsaE PF02367.17 ETO18962.1 - 0.033 14.2 0.0 0.052 13.5 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase PF06745.13 ETO18962.1 - 0.057 12.8 0.0 0.12 11.6 0.0 1.6 1 0 0 1 1 1 0 KaiC TIP49 PF06068.13 ETO18962.1 - 0.07 12.3 0.0 0.11 11.7 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain ATPase_2 PF01637.18 ETO18962.1 - 0.079 12.9 0.1 1.8 8.4 0.0 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 ETO18962.1 - 0.091 13.3 0.0 0.27 11.8 0.0 2.0 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ETO18962.1 - 0.14 11.7 0.4 0.88 9.1 0.1 2.1 1 1 1 2 2 2 0 AAA domain CPT PF07931.12 ETO18962.1 - 0.19 11.6 0.0 0.38 10.6 0.0 1.5 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TPD52 PF04201.15 ETO18963.1 - 0.0026 17.4 2.0 0.0042 16.7 2.0 1.4 1 0 0 1 1 1 1 Tumour protein D52 family Spc7 PF08317.11 ETO18963.1 - 0.0037 16.2 5.2 0.0038 16.2 4.1 1.5 1 1 0 1 1 1 1 Spc7 kinetochore protein Stevor PF17410.2 ETO18963.1 - 0.0077 15.8 0.4 0.0091 15.6 0.4 1.2 1 0 0 1 1 1 1 Subtelomeric Variable Open Reading frame IBN_N PF03810.19 ETO18963.1 - 0.008 16.1 3.5 0.13 12.2 0.0 2.6 3 0 0 3 3 3 1 Importin-beta N-terminal domain DUF4446 PF14584.6 ETO18963.1 - 0.031 14.3 2.7 0.042 13.8 0.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) BTAD PF03704.17 ETO18963.1 - 0.069 13.6 0.2 0.11 12.9 0.2 1.3 1 0 0 1 1 1 0 Bacterial transcriptional activator domain DUF3958 PF13125.6 ETO18963.1 - 0.13 12.5 6.7 0.26 11.5 6.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3958) Fib_alpha PF08702.10 ETO18963.1 - 0.99 9.6 10.2 0.21 11.7 4.9 2.2 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Ubiq_cyt_C_chap PF03981.12 ETO18964.1 - 0.0001 22.4 0.1 0.00015 21.8 0.1 1.3 1 0 0 1 1 1 1 Ubiquinol-cytochrome C chaperone VWD PF00094.25 ETO18967.1 - 1.4e-11 44.9 0.4 6e-11 42.8 0.4 2.0 1 1 0 1 1 1 1 von Willebrand factor type D domain AMOP PF03782.17 ETO18967.1 - 5.6e-08 33.0 3.7 5.6e-08 33.0 3.7 1.8 2 0 0 2 2 2 1 AMOP domain Choline_kinase PF01633.20 ETO18968.1 - 4.7e-26 91.7 3.6 5.7e-26 91.4 3.6 1.0 1 0 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ETO18968.1 - 6.1e-08 32.9 0.1 1.2e-05 25.4 0.0 2.1 2 0 0 2 2 2 2 Phosphotransferase enzyme family Mad3_BUB1_I_2 PF17014.5 ETO18968.1 - 0.034 14.3 1.9 7.7 6.7 0.2 2.7 1 1 1 3 3 3 0 Putative Mad3/BUB1 like region 1 protein zf-IS66 PF13005.7 ETO18968.1 - 0.15 12.5 0.1 0.39 11.1 0.1 1.7 1 0 0 1 1 1 0 zinc-finger binding domain of transposase IS66 Red1 PF07964.11 ETO18970.1 - 0.017 13.4 23.4 0.018 13.3 23.4 1.1 1 0 0 1 1 1 0 Rec10 / Red1 DUF1387 PF07139.11 ETO18970.1 - 0.61 9.8 19.2 0.78 9.4 19.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Draxin PF15550.6 ETO18970.1 - 0.66 9.8 12.3 0.85 9.4 12.3 1.2 1 0 0 1 1 1 0 Draxin DUF4551 PF15087.6 ETO18970.1 - 0.76 8.5 13.1 0.76 8.5 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Menin PF05053.13 ETO18970.1 - 2.9 6.1 11.6 3 6.1 11.6 1.2 1 0 0 1 1 1 0 Menin Adaptin_N PF01602.20 ETO18973.1 - 1.1e-23 83.6 0.0 1.4e-23 83.3 0.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO18973.1 - 5.3e-10 39.6 0.0 6.9e-10 39.2 0.0 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO18973.1 - 0.00035 20.6 0.3 2 8.9 0.0 3.4 3 0 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO18973.1 - 0.012 15.9 0.0 0.1 13.0 0.0 1.9 1 1 0 1 1 1 0 HEAT repeats API5 PF05918.11 ETO18973.1 - 0.066 12.0 0.0 0.078 11.8 0.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) NPA PF16469.5 ETO18974.1 - 0.053 14.1 6.5 0.077 13.6 0.5 2.1 2 0 0 2 2 2 0 Nematode polyprotein allergen ABA-1 GrpE PF01025.19 ETO18974.1 - 0.063 12.9 2.4 0.083 12.5 2.4 1.3 1 0 0 1 1 1 0 GrpE TRAUB PF08164.12 ETO18974.1 - 0.077 13.5 0.0 0.077 13.5 0.0 2.1 1 1 1 2 2 2 0 Apoptosis-antagonizing transcription factor, C-terminal DUF4257 PF14074.6 ETO18974.1 - 0.16 12.2 1.0 0.26 11.5 0.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF4257) BPL_N PF09825.9 ETO18974.1 - 0.18 10.9 0.9 0.21 10.6 0.9 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal UCH PF00443.29 ETO18974.1 - 0.33 10.4 3.7 0.44 10.0 3.7 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase SAP PF02037.27 ETO18975.1 - 2.7e-09 36.6 0.8 2.7e-09 36.6 0.8 1.8 2 0 0 2 2 2 1 SAP domain GAGA_bind PF06217.12 ETO18975.1 - 0.33 11.2 6.4 0.42 10.8 6.4 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family GyrB_insert PF18053.1 ETO18976.1 - 0.57 10.1 6.2 0.72 9.7 4.7 1.7 2 0 0 2 2 2 0 DNA gyrase B subunit insert domain Csm2_III-A PF03750.13 ETO18976.1 - 3.1 8.7 8.4 1 10.2 5.3 1.9 2 0 0 2 2 2 0 Csm2 Type III-A NRBF2 PF08961.10 ETO18977.1 - 0.00038 20.1 5.4 0.00038 20.1 5.4 2.3 1 1 1 2 2 1 1 Nuclear receptor-binding factor 2, autophagy regulator CENP-F_leu_zip PF10473.9 ETO18977.1 - 0.0011 19.0 38.8 0.0047 16.9 5.3 3.5 2 1 1 3 3 3 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 ETO18977.1 - 0.0021 18.1 21.9 0.0021 18.1 21.9 3.9 1 1 2 4 4 4 1 TPR/MLP1/MLP2-like protein SOGA PF11365.8 ETO18977.1 - 0.0079 17.3 1.2 0.0079 17.3 1.2 4.3 1 1 4 5 5 5 1 Protein SOGA Fez1 PF06818.15 ETO18977.1 - 0.009 16.5 34.8 0.023 15.2 27.9 2.4 2 1 1 3 3 2 1 Fez1 DUF948 PF06103.11 ETO18977.1 - 0.018 15.3 9.8 0.079 13.2 0.6 3.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 ETO18977.1 - 0.018 15.3 34.7 0.097 12.9 11.6 3.5 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.11 ETO18977.1 - 0.023 14.9 40.3 0.42 10.8 18.4 3.2 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) NPV_P10 PF05531.12 ETO18977.1 - 0.083 13.4 18.0 0.062 13.8 3.8 3.7 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein APG6_N PF17675.1 ETO18977.1 - 0.14 12.7 39.5 0.3 11.6 22.0 2.8 2 1 1 3 3 2 0 Apg6 coiled-coil region Rab5-bind PF09311.11 ETO18977.1 - 0.14 11.5 35.6 0.76 9.1 33.5 2.4 1 1 0 2 2 2 0 Rabaptin-like protein Spc7 PF08317.11 ETO18977.1 - 0.23 10.3 36.4 0.13 11.2 16.7 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein YscO PF07321.12 ETO18977.1 - 0.3 11.0 30.1 2.5 8.0 14.1 3.1 1 1 2 3 3 3 0 Type III secretion protein YscO UPF0242 PF06785.11 ETO18977.1 - 0.35 11.0 37.8 0.71 9.9 7.9 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Filament PF00038.21 ETO18977.1 - 0.35 10.4 35.8 0.011 15.3 21.2 2.4 2 1 1 3 3 3 0 Intermediate filament protein ERM PF00769.19 ETO18977.1 - 0.55 10.0 34.7 0.85 9.4 9.8 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family ADIP PF11559.8 ETO18977.1 - 0.8 9.8 42.4 0.24 11.5 13.2 3.2 2 1 3 5 5 3 0 Afadin- and alpha -actinin-Binding Transthyretin PF00576.21 ETO18977.1 - 0.98 10.1 3.9 0.46 11.2 1.2 1.8 1 1 1 2 2 2 0 HIUase/Transthyretin family FlaC_arch PF05377.11 ETO18977.1 - 1 9.8 15.3 6.3 7.3 5.9 4.1 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) HrpB7 PF09486.10 ETO18977.1 - 1.4 9.3 17.1 0.12 12.8 2.1 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) YabA PF06156.13 ETO18977.1 - 1.7 9.4 30.0 0.36 11.5 2.0 3.9 1 1 2 4 4 4 0 Initiation control protein YabA Mod_r PF07200.13 ETO18977.1 - 2.4 8.2 36.7 0.1 12.7 11.0 2.8 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF4407 PF14362.6 ETO18977.1 - 2.6 7.3 25.6 14 4.9 25.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ApoO PF09769.9 ETO18977.1 - 2.9 7.9 10.7 2.1 8.3 2.7 3.0 2 1 1 3 3 3 0 Apolipoprotein O Fmp27_WPPW PF10359.9 ETO18977.1 - 3.1 6.5 30.2 0.021 13.7 9.8 2.1 1 1 1 2 2 2 0 RNA pol II promoter Fmp27 protein domain Nmad5 PF18757.1 ETO18977.1 - 4 7.6 18.5 1.3e+02 2.7 16.7 2.8 1 1 1 2 2 2 0 Nucleotide modification associated domain 5 Tropomyosin_1 PF12718.7 ETO18977.1 - 4.2 7.5 36.1 27 4.9 22.1 2.5 1 1 1 2 2 2 0 Tropomyosin like OmpH PF03938.14 ETO18977.1 - 4.3 7.7 39.8 2.3 8.5 18.8 2.6 1 1 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF3450 PF11932.8 ETO18977.1 - 4.3 6.6 35.3 0.21 10.8 8.5 3.2 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) Baculo_PEP_C PF04513.12 ETO18977.1 - 4.7 7.3 14.9 1.7 8.7 5.6 2.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF812 PF05667.11 ETO18977.1 - 5.5 5.7 36.9 1.3e+02 1.2 35.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF812) bZIP_1 PF00170.21 ETO18977.1 - 6.3 7.0 29.3 0.38 10.9 2.2 5.4 3 2 4 7 7 6 0 bZIP transcription factor HAP1_N PF04849.13 ETO18977.1 - 6.4 5.9 37.0 17 4.5 37.0 1.8 1 1 0 1 1 1 0 HAP1 N-terminal conserved region Kinesin PF00225.23 ETO18978.1 - 1.5e-22 80.0 1.3 2e-22 79.6 1.3 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO18978.1 - 4.9e-10 39.5 0.3 4.9e-10 39.5 0.3 1.6 2 0 0 2 2 2 1 Microtubule binding wnt PF00110.19 ETO18978.1 - 0.075 12.6 0.7 0.091 12.3 0.7 1.2 1 0 0 1 1 1 0 wnt family Metallophos PF00149.28 ETO18979.1 - 2.1e-17 64.3 0.0 2.5e-17 64.1 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO18979.1 - 0.2 11.8 0.0 0.26 11.5 0.0 1.1 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain PDEase_I PF00233.19 ETO18980.1 - 3.2e-46 158.0 11.5 1.4e-36 126.4 0.1 3.3 3 0 0 3 3 3 2 3'5'-cyclic nucleotide phosphodiesterase EF-hand_13 PF17958.1 ETO18980.1 - 0.092 12.6 0.3 0.26 11.1 0.3 1.7 1 0 0 1 1 1 0 EF-hand domain SCF PF02404.15 ETO18981.1 - 0.037 13.4 0.6 0.098 12.0 0.1 1.9 1 1 0 1 1 1 0 Stem cell factor Biopterin_H PF00351.21 ETO18981.1 - 0.068 12.2 0.0 0.11 11.5 0.0 1.3 1 0 0 1 1 1 0 Biopterin-dependent aromatic amino acid hydroxylase PhoR PF11808.8 ETO18981.1 - 5.6 7.5 8.4 2.4 8.7 1.0 2.7 2 1 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF3040 PF11239.8 ETO18981.1 - 6.1 7.2 13.6 1 9.7 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Vta1 PF04652.16 ETO18982.1 - 1.2e-28 99.9 4.0 1.4e-28 99.7 4.0 1.0 1 0 0 1 1 1 1 Vta1 like USP8_dimer PF08969.11 ETO18982.1 - 0.044 14.0 0.8 0.15 12.2 0.1 2.0 1 1 0 2 2 2 0 USP8 dimerisation domain HERV-K_REC PF15695.5 ETO18982.1 - 0.074 13.1 2.6 0.098 12.7 2.1 1.6 1 1 0 1 1 1 0 Rec (regulator of expression encoded by corf) of HERV-K-113 DEAD PF00270.29 ETO18983.1 - 1.3e-09 38.0 0.2 2.8e-09 37.0 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO18983.1 - 2.6e-09 37.3 1.4 4.4e-09 36.6 1.4 1.6 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit DUF5048 PF16467.5 ETO18983.1 - 0.05 13.9 0.8 0.09 13.1 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF5048) AAA_19 PF13245.6 ETO18983.1 - 0.086 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain DUF957 PF06117.11 ETO18983.1 - 0.69 9.5 2.5 2.9 7.5 0.1 2.7 3 0 0 3 3 3 0 Enterobacterial protein of unknown function (DUF957) Ilm1 PF10311.9 ETO18984.1 - 0.016 14.9 0.1 0.029 14.0 0.1 1.4 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 DUF4131 PF13567.6 ETO18984.1 - 0.054 13.2 1.5 1.2 8.7 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MRAP PF15183.6 ETO18984.1 - 0.1 12.5 1.3 1.2 9.2 0.3 2.5 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family DUF805 PF05656.14 ETO18984.1 - 4.7 7.7 6.2 0.91 10.0 1.8 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF805) Ank_5 PF13857.6 ETO18985.1 - 5.7e-08 32.9 0.2 1.5e-05 25.2 0.2 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO18985.1 - 7.4e-08 32.5 0.1 0.014 15.8 0.3 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ETO18985.1 - 4.5e-07 30.4 0.0 6.9e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO18985.1 - 9.1e-07 29.3 0.1 1.7e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO18985.1 - 4.1e-06 26.7 0.1 0.0072 16.8 0.2 2.5 2 0 0 2 2 2 2 Ankyrin repeat TPR_17 PF13431.6 ETO18986.1 - 1.1e-06 28.6 3.5 0.0023 18.2 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO18986.1 - 0.00087 19.9 0.1 0.0037 18.0 0.0 2.0 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO18986.1 - 0.0015 18.2 0.9 0.006 16.2 0.0 2.2 1 1 1 2 2 2 1 TPR repeat TPR_2 PF07719.17 ETO18986.1 - 0.0028 17.7 2.1 0.0033 17.4 0.2 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO18986.1 - 0.0092 16.5 2.4 0.047 14.2 2.4 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO18986.1 - 0.016 15.5 0.6 0.039 14.2 0.6 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat NLRC4_HD2 PF17776.1 ETO18986.1 - 0.034 14.7 0.1 0.062 13.8 0.1 1.4 1 0 0 1 1 1 0 NLRC4 helical domain HD2 Fis1_TPR_C PF14853.6 ETO18986.1 - 0.062 13.4 0.2 0.25 11.5 0.0 2.1 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Peptidase_M18 PF02127.15 ETO18986.1 - 0.098 11.4 1.4 2.5 6.8 0.2 2.0 1 1 0 2 2 2 0 Aminopeptidase I zinc metalloprotease (M18) AgrB PF04647.15 ETO18986.1 - 0.12 11.7 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 Accessory gene regulator B TPR_1 PF00515.28 ETO18986.1 - 0.17 11.8 0.3 0.17 11.8 0.3 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Glucosamine_iso PF01182.20 ETO18987.1 - 3e-52 177.7 0.0 3.6e-52 177.5 0.0 1.1 1 0 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase Presenilin PF01080.17 ETO18989.1 - 0.017 13.9 0.8 0.022 13.6 0.8 1.2 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 ETO18989.1 - 0.037 13.8 0.1 0.061 13.1 0.1 1.3 1 0 0 1 1 1 0 Connexin Pox_Ag35 PF03286.14 ETO18989.1 - 0.041 13.7 2.5 0.074 12.8 2.5 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ETO18989.1 - 0.96 8.6 3.4 1.4 8.1 3.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO18989.1 - 1.1 10.2 5.7 2.6 9.0 5.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF2076 PF09849.9 ETO18989.1 - 1.4 8.9 9.8 2.3 8.2 9.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Menin PF05053.13 ETO18989.1 - 1.9 6.7 9.7 2.7 6.2 9.7 1.2 1 0 0 1 1 1 0 Menin APG5 PF04106.12 ETO18993.1 - 1.1e-45 156.0 0.2 1.1e-45 156.0 0.2 1.8 2 0 0 2 2 2 1 Autophagy protein Apg5 Acyl-CoA_dh_1 PF00441.24 ETO18994.1 - 4.2e-32 111.4 0.2 6.9e-32 110.7 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO18994.1 - 2.6e-14 53.6 0.0 3.8e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO18994.1 - 0.00015 21.9 0.1 0.00052 20.2 0.1 1.9 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, middle domain zf-C4H2 PF10146.9 ETO18997.1 - 0.00015 22.1 1.0 0.00015 22.1 1.0 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein DUF2972 PF11186.8 ETO18997.1 - 0.0035 17.3 2.9 0.0076 16.2 1.1 1.9 1 1 1 2 2 2 2 Protein of unknown function (DUF2972) SPACA9 PF15120.6 ETO18997.1 - 0.024 14.4 0.3 0.035 13.9 0.3 1.3 1 0 0 1 1 1 0 Sperm acrosome-associated protein 9 FA_hydroxylase PF04116.13 ETO18998.1 - 1.8e-20 73.6 22.7 2.5e-20 73.2 22.7 1.2 1 0 0 1 1 1 1 Fatty acid hydroxylase superfamily HAD_2 PF13419.6 ETO18999.1 - 8.9e-17 61.7 0.1 8.5e-14 52.0 0.1 2.2 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETO18999.1 - 0.0032 17.5 0.0 0.0057 16.7 0.0 1.5 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ETO18999.1 - 0.0069 16.7 0.0 0.22 11.8 0.0 2.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase DUF2863 PF11062.8 ETO18999.1 - 0.045 12.2 0.1 0.091 11.1 0.0 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2863) Apis_Csd PF11671.8 ETO19000.1 - 0.42 10.6 7.1 0.41 10.7 0.6 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein LapA_dom PF06305.11 ETO19001.1 - 2 8.3 5.3 5.3 6.9 0.0 2.8 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain TMEM237 PF15383.6 ETO19001.1 - 3.6 6.6 11.8 0.41 9.7 0.1 2.3 2 0 0 2 2 2 0 Transmembrane protein 237 MFS_2 PF13347.6 ETO19004.1 - 0.0052 15.4 0.1 0.0065 15.1 0.1 1.1 1 0 0 1 1 1 1 MFS/sugar transport protein BCCT PF02028.17 ETO19004.1 - 0.16 10.4 1.6 0.21 10.0 1.6 1.1 1 0 0 1 1 1 0 BCCT, betaine/carnitine/choline family transporter NESP55 PF06390.12 ETO19004.1 - 7.6 6.0 10.4 3.6 7.1 8.1 1.5 1 1 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) F-box_4 PF15966.5 ETO19005.1 - 0.011 15.6 0.2 0.038 13.9 0.0 1.9 1 1 1 2 2 2 0 F-box SHMT PF00464.19 ETO19006.1 - 7.2e-137 456.2 0.1 1.2e-111 373.2 0.0 3.1 1 1 1 3 3 3 3 Serine hydroxymethyltransferase tRNA_m1G_MT PF01746.21 ETO19007.1 - 6.2e-11 42.4 0.1 1.2e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 tRNA (Guanine-1)-methyltransferase Adeno_terminal PF02459.15 ETO19007.1 - 0.00016 20.3 2.9 0.00016 20.3 2.9 1.7 2 0 0 2 2 2 1 Adenoviral DNA terminal protein H-K_ATPase_N PF09040.11 ETO19008.1 - 0.0063 16.9 1.6 0.0063 16.9 1.6 2.5 2 0 0 2 2 2 1 Gastric H+/K+-ATPase, N terminal domain DUF5582 PF17819.1 ETO19008.1 - 0.013 15.9 1.3 0.013 15.9 1.3 1.7 2 1 0 2 2 2 0 Family of unknown function (DUF5582) DUF1754 PF08555.10 ETO19008.1 - 0.022 15.6 10.0 0.022 15.6 10.0 2.5 3 0 0 3 3 3 0 Eukaryotic family of unknown function (DUF1754) DUF1043 PF06295.12 ETO19008.1 - 0.03 14.3 0.5 0.03 14.3 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) CFIA_Pcf11 PF11526.8 ETO19008.1 - 0.23 12.0 6.8 0.078 13.5 3.7 1.8 2 1 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 DUF3391 PF11871.8 ETO19008.1 - 1.5 9.3 7.5 15 6.2 7.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) SET PF00856.28 ETO19008.1 - 7 7.0 6.6 65 3.9 6.6 2.1 1 1 0 1 1 1 0 SET domain DUF1604 PF07713.13 ETO19009.1 - 1.9e-18 66.0 0.1 1.9e-18 66.0 0.1 3.3 3 0 0 3 3 3 1 Protein of unknown function (DUF1604) G-patch PF01585.23 ETO19009.1 - 0.006 16.4 0.7 0.012 15.5 0.7 1.5 1 0 0 1 1 1 1 G-patch domain Myosin_head PF00063.21 ETO19010.1 - 5.6e-51 173.6 1.2 6.7e-51 173.3 1.2 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) RNA_helicase PF00910.22 ETO19010.1 - 0.021 15.2 0.3 0.089 13.2 0.3 1.9 1 1 0 1 1 1 0 RNA helicase Ras PF00071.22 ETO19012.1 - 5e-51 172.5 0.0 6.4e-51 172.2 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO19012.1 - 3.2e-28 98.4 0.1 6.7e-28 97.3 0.0 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO19012.1 - 1.5e-13 50.6 0.0 1.8e-13 50.3 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO19012.1 - 2.3e-05 24.5 0.0 3.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO19012.1 - 0.00068 19.2 0.1 0.024 14.2 0.0 2.4 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain AAA_16 PF13191.6 ETO19012.1 - 0.0014 19.0 0.0 0.0024 18.3 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO19012.1 - 0.0029 17.9 0.0 0.0047 17.2 0.0 1.5 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO19012.1 - 0.003 17.5 0.0 0.22 11.4 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 ETO19012.1 - 0.017 15.0 0.1 0.066 13.1 0.1 2.0 2 0 0 2 2 2 0 NACHT domain SRPRB PF09439.10 ETO19012.1 - 0.023 14.2 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit TniB PF05621.11 ETO19012.1 - 0.046 13.1 0.0 0.069 12.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein PGA2 PF07543.12 ETO19014.1 - 0.014 15.3 14.6 0.063 13.3 13.2 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 BSP_II PF05432.11 ETO19014.1 - 0.076 12.7 26.9 0.021 14.5 24.2 1.4 1 1 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF1682 PF07946.14 ETO19014.1 - 0.083 12.1 5.8 0.12 11.6 5.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Presenilin PF01080.17 ETO19014.1 - 0.18 10.5 8.3 0.18 10.5 8.3 1.1 1 0 0 1 1 1 0 Presenilin CRT10 PF08728.10 ETO19014.1 - 0.2 9.8 5.4 0.22 9.7 5.4 1.1 1 0 0 1 1 1 0 CRT10 NPR3 PF03666.13 ETO19014.1 - 0.61 8.8 8.3 0.65 8.7 8.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Membralin PF09746.9 ETO19014.1 - 0.78 8.7 3.8 0.92 8.5 3.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein CPSF100_C PF13299.6 ETO19014.1 - 1.1 9.4 7.5 1.8 8.8 7.5 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM60A PF15396.6 ETO19014.1 - 1.3 9.0 6.4 1.7 8.6 6.4 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Sec62 PF03839.16 ETO19014.1 - 1.4 8.4 6.0 2.1 7.8 6.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 FYDLN_acid PF09538.10 ETO19014.1 - 1.7 9.3 14.0 1.2 9.8 9.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) PAXIP1_C PF15364.6 ETO19014.1 - 1.9 8.8 14.1 0.06 13.7 7.5 1.8 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein Zip PF02535.22 ETO19014.1 - 2.6 7.2 4.5 3 7.0 4.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Myc_N PF01056.18 ETO19014.1 - 4.2 7.2 11.6 0.49 10.2 7.7 1.5 2 0 0 2 2 2 0 Myc amino-terminal region TFB6 PF17110.5 ETO19014.1 - 4.6 7.0 10.5 2.3 7.9 7.3 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CDC45 PF02724.14 ETO19014.1 - 5.6 5.1 13.0 6.2 5.0 13.0 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4820 PF16091.5 ETO19014.1 - 5.9 6.2 10.3 9.1 5.6 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4637 PF15470.6 ETO19014.1 - 7.8 6.2 12.2 1.8e+02 1.7 13.9 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) MMPL PF03176.15 ETO19015.1 - 3.6e-28 98.5 3.0 3.4e-25 88.7 2.9 2.2 1 1 0 1 1 1 1 MMPL family SNF2_N PF00176.23 ETO19016.1 - 1.4e-28 99.6 0.1 2.3e-28 98.9 0.1 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO19016.1 - 1.1e-13 51.5 1.1 6.7e-13 49.0 0.0 2.8 4 0 0 4 4 4 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO19016.1 - 2.2e-11 44.1 1.5 3.5e-08 33.7 0.0 3.7 3 1 0 4 4 4 1 Type III restriction enzyme, res subunit ERCC3_RAD25_C PF16203.5 ETO19016.1 - 0.0051 16.1 0.1 0.01 15.0 0.1 1.4 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase DUF4164 PF13747.6 ETO19016.1 - 0.41 11.0 5.2 1.1 9.5 0.6 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4164) DUF4407 PF14362.6 ETO19017.1 - 0.0057 16.0 0.1 0.0073 15.7 0.1 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) PRP1_N PF06424.12 ETO19017.1 - 1.2 9.5 16.3 1 9.7 5.9 2.4 2 1 0 2 2 2 0 PRP1 splicing factor, N-terminal ALMT PF11744.8 ETO19017.1 - 3.1 6.5 7.1 4.1 6.1 7.1 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter ETRAMP PF09716.10 ETO19017.1 - 7.3 6.7 10.9 18 5.5 0.1 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) AMNp_N PF10423.9 ETO19018.1 - 0.092 12.4 0.1 0.22 11.1 0.0 1.7 2 0 0 2 2 2 0 Bacterial AMP nucleoside phosphorylase N-terminus UT PF03253.14 ETO19019.1 - 1.2e-29 103.3 13.6 1.5e-29 103.0 13.6 1.0 1 0 0 1 1 1 1 Urea transporter TehB PF03848.14 ETO19023.1 - 0.011 15.2 0.1 0.014 14.8 0.1 1.2 1 0 0 1 1 1 0 Tellurite resistance protein TehB Cnd1 PF12717.7 ETO19023.1 - 0.033 14.2 0.1 1.5 8.8 0.1 2.1 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DUF5357 PF17310.2 ETO19024.1 - 0.0014 17.2 0.5 0.0024 16.5 0.5 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5357) PH_12 PF16457.5 ETO19024.1 - 0.008 16.7 0.2 0.008 16.7 0.2 2.6 2 0 0 2 2 2 1 Pleckstrin homology domain ThiS PF02597.20 ETO19024.1 - 0.021 15.4 0.7 0.048 14.3 0.7 1.7 1 0 0 1 1 1 0 ThiS family PH PF00169.29 ETO19024.1 - 0.032 14.7 0.2 0.032 14.7 0.2 3.1 4 0 0 4 4 4 0 PH domain COMP PF11598.8 ETO19024.1 - 0.22 12.0 2.1 6.1 7.4 0.0 2.6 2 0 0 2 2 2 0 Cartilage oligomeric matrix protein SpmSyn_N PF17950.1 ETO19024.1 - 0.35 11.1 4.7 0.37 11.0 0.5 2.7 2 1 1 3 3 3 0 S-adenosylmethionine decarboxylase N -terminal Lectin_N PF03954.14 ETO19024.1 - 0.48 10.2 2.4 0.88 9.3 1.5 2.0 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain UCH PF00443.29 ETO19025.1 - 1.2e-28 100.3 0.5 1.2e-28 100.3 0.5 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO19025.1 - 2.5e-16 60.2 2.6 8.5e-16 58.4 0.2 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ETO19025.1 - 1.6e-11 44.7 0.5 1.6e-11 44.7 0.5 2.6 2 1 0 2 2 2 1 DUSP domain WD40 PF00400.32 ETO19028.1 - 1.8e-11 44.4 1.9 0.0031 18.3 0.0 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat Phage_CI_C PF16452.5 ETO19028.1 - 0.077 13.3 0.1 3.5 8.0 0.0 2.3 1 1 1 2 2 2 0 Bacteriophage CI repressor C-terminal domain DUF4407 PF14362.6 ETO19029.1 - 0.0033 16.8 1.3 0.0043 16.4 1.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) Synaptonemal_3 PF15191.6 ETO19029.1 - 0.005 16.6 1.6 0.035 13.9 0.1 2.5 2 0 0 2 2 2 1 Synaptonemal complex central element protein 3 LPP PF04728.13 ETO19029.1 - 0.0065 16.8 4.2 0.35 11.3 0.9 2.4 2 0 0 2 2 2 1 Lipoprotein leucine-zipper MbeD_MobD PF04899.12 ETO19029.1 - 0.0071 16.4 1.5 1.8 8.7 0.0 2.5 1 1 1 2 2 2 1 MbeD/MobD like TUG-UBL1 PF11470.8 ETO19029.1 - 0.013 15.7 0.1 0.034 14.4 0.0 1.8 2 0 0 2 2 1 0 TUG ubiquitin-like domain DUF4200 PF13863.6 ETO19029.1 - 0.013 15.9 9.1 0.53 10.7 1.3 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) FlxA PF14282.6 ETO19029.1 - 0.015 15.3 14.3 0.27 11.2 2.8 2.2 1 1 0 2 2 2 0 FlxA-like protein PRKG1_interact PF15898.5 ETO19029.1 - 0.016 16.1 6.1 0.036 15.0 6.1 1.5 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 ETO19029.1 - 0.019 14.7 6.1 0.12 12.2 1.7 2.4 2 0 0 2 2 2 0 Septum formation initiator ABC_tran_CTD PF16326.5 ETO19029.1 - 0.093 13.0 6.0 0.38 11.0 0.5 2.3 1 1 1 2 2 2 0 ABC transporter C-terminal domain CtIP_N PF10482.9 ETO19029.1 - 0.11 12.6 5.7 0.26 11.3 5.7 1.6 1 0 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain DUF2205 PF10224.9 ETO19029.1 - 0.23 11.5 3.7 1.2 9.2 0.5 2.4 2 0 0 2 2 2 0 Short coiled-coil protein TPR_MLP1_2 PF07926.12 ETO19029.1 - 0.24 11.4 8.6 0.53 10.4 8.4 1.6 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4061 PF13270.6 ETO19029.1 - 0.4 11.0 3.4 1.5 9.2 3.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4061) Fib_alpha PF08702.10 ETO19029.1 - 0.68 10.1 11.9 0.25 11.5 9.2 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF5320 PF17253.2 ETO19029.1 - 0.75 10.9 4.2 17 6.5 0.4 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5320) DUF4041 PF13250.6 ETO19029.1 - 0.86 9.5 6.7 7.2 6.6 0.9 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4041) Tropomyosin_1 PF12718.7 ETO19029.1 - 1.1 9.4 10.6 0.58 10.3 3.9 2.2 1 1 1 2 2 2 0 Tropomyosin like PspA_IM30 PF04012.12 ETO19029.1 - 1.5 8.4 6.5 1 8.9 0.4 2.3 1 1 0 2 2 2 0 PspA/IM30 family DUF4140 PF13600.6 ETO19029.1 - 2.1 8.8 4.4 6.4 7.3 0.5 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) ZapB PF06005.12 ETO19029.1 - 2.6 8.6 9.5 1.2 9.7 0.6 2.4 2 0 0 2 2 2 0 Cell division protein ZapB BLOC1_2 PF10046.9 ETO19029.1 - 4.8 7.6 12.2 3.1 8.2 2.5 2.8 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YlqD PF11068.8 ETO19029.1 - 5.1 7.5 9.9 11 6.4 9.9 1.5 1 1 0 1 1 1 0 YlqD protein bZIP_2 PF07716.15 ETO19029.1 - 6.2 7.0 9.7 0.83 9.8 0.8 2.6 3 0 0 3 3 2 0 Basic region leucine zipper SAM_1 PF00536.30 ETO19030.1 - 1.6e-07 31.7 0.7 2.5e-07 31.0 0.7 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO19030.1 - 2.2e-05 24.4 0.3 4.5e-05 23.3 0.3 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain RhoGAP PF00620.27 ETO19031.1 - 2.9e-09 36.9 0.0 3.5e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain EF-hand_6 PF13405.6 ETO19032.1 - 3e-06 26.7 0.4 0.065 13.2 0.1 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO19032.1 - 2.1e-05 24.9 0.9 3.7e-05 24.1 0.9 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO19032.1 - 0.00015 21.0 1.3 0.08 12.5 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 ETO19032.1 - 0.093 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 EF hand Mucin PF01456.17 ETO19032.1 - 0.34 10.9 34.3 0.48 10.4 34.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Tir_receptor_C PF07489.11 ETO19032.1 - 0.85 9.6 13.3 1.2 9.1 13.3 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus TPR_12 PF13424.6 ETO19033.1 - 9.8e-05 22.6 1.4 0.7 10.2 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO19033.1 - 0.00014 21.7 7.7 0.011 15.8 0.6 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19033.1 - 0.00027 20.9 10.0 0.037 14.2 0.7 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO19033.1 - 0.015 16.1 0.2 1.3 10.0 0.0 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO19033.1 - 0.027 14.4 0.3 2 8.4 0.0 3.2 2 1 1 3 3 3 0 Tetratricopeptide repeat NOG1_N PF17835.1 ETO19033.1 - 0.05 13.6 0.1 0.43 10.5 0.0 2.1 2 0 0 2 2 2 0 NOG1 N-terminal helical domain CCP_MauG PF03150.14 ETO19033.1 - 0.064 13.9 0.1 0.11 13.1 0.1 1.2 1 1 0 1 1 1 0 Di-haem cytochrome c peroxidase UVR PF02151.19 ETO19033.1 - 0.064 13.0 3.6 0.19 11.5 0.3 2.5 2 0 0 2 2 2 0 UvrB/uvrC motif INSC_LBD PF16748.5 ETO19033.1 - 0.098 12.1 0.6 0.24 10.9 0.3 1.8 2 0 0 2 2 2 0 Inscuteable LGN-binding domain NOA36 PF06524.12 ETO19034.1 - 4.9 6.4 10.9 7.2 5.8 10.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2076 PF09849.9 ETO19034.1 - 7.3 6.5 12.9 10 6.1 12.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DNA_pol_phi PF04931.13 ETO19035.1 - 0.03 12.5 18.9 0.043 11.9 0.2 2.1 2 0 0 2 2 2 0 DNA polymerase phi HSP70 PF00012.20 ETO19035.1 - 0.12 10.6 0.0 0.12 10.6 0.0 2.3 3 0 0 3 3 3 0 Hsp70 protein Menin PF05053.13 ETO19035.1 - 0.98 7.7 16.0 0.37 9.1 5.4 2.1 2 0 0 2 2 2 0 Menin Spt5_N PF11942.8 ETO19035.1 - 5.5 8.0 18.8 4.9 8.2 11.4 2.4 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal TRAP_alpha PF03896.16 ETO19035.1 - 7.7 5.6 12.3 0.9 8.7 4.5 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit RTT107_BRCT_5 PF16770.5 ETO19036.1 - 0.00098 19.0 3.8 0.014 15.3 0.0 3.7 2 1 1 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain TAF4 PF05236.14 ETO19036.1 - 0.0052 16.6 9.1 0.0072 16.1 9.1 1.3 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family BRCT_2 PF16589.5 ETO19036.1 - 0.0088 16.4 0.1 0.095 13.1 0.0 2.5 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETO19036.1 - 0.013 15.9 2.8 0.11 12.9 0.1 2.8 2 1 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain YL1 PF05764.13 ETO19036.1 - 0.046 13.8 23.2 0.08 13.0 23.2 1.4 1 0 0 1 1 1 0 YL1 nuclear protein TFIIF_alpha PF05793.12 ETO19036.1 - 0.5 8.9 25.0 0.75 8.3 25.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 ETO19036.1 - 0.55 8.5 24.1 0.75 8.0 24.1 1.2 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 ETO19036.1 - 0.73 8.8 13.0 4.1 6.3 10.8 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Zip PF02535.22 ETO19036.1 - 1.6 7.9 8.0 2.5 7.2 8.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 ETO19036.1 - 1.7 7.4 9.1 2.1 7.0 9.1 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF4698 PF15769.5 ETO19036.1 - 3.5 6.6 15.0 9.3 5.2 15.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4698) RUN PF02759.19 ETO19038.1 - 2.6e-07 30.6 0.1 5.9e-07 29.5 0.1 1.6 1 0 0 1 1 1 1 RUN domain Nop14 PF04147.12 ETO19038.1 - 0.0096 14.2 25.5 0.013 13.8 25.5 1.1 1 0 0 1 1 1 1 Nop14-like family BSP_II PF05432.11 ETO19038.1 - 0.53 9.9 32.6 0.77 9.4 32.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) LAP1C PF05609.12 ETO19038.1 - 0.66 9.0 24.0 0.83 8.7 24.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RRN3 PF05327.11 ETO19038.1 - 0.71 8.3 16.3 0.87 8.1 16.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 BUD22 PF09073.10 ETO19038.1 - 5.4 6.2 29.7 9.9 5.4 29.7 1.4 1 0 0 1 1 1 0 BUD22 DUF2981 PF11200.8 ETO19038.1 - 9.4 5.9 14.7 13 5.5 14.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF4913 PF16259.5 ETO19040.1 - 0.035 14.2 0.1 0.11 12.6 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4913) IMPa_helical PF18642.1 ETO19040.1 - 0.045 14.2 1.5 0.078 13.4 0.3 2.0 2 0 0 2 2 2 0 Immunomodulating metalloprotease helical domain DUF262 PF03235.14 ETO19040.1 - 6 7.0 13.6 29 4.8 13.6 1.9 1 1 0 1 1 1 0 Protein of unknown function DUF262 Sec3_C_2 PF15278.6 ETO19041.1 - 0.0037 17.6 2.6 0.071 13.5 1.5 2.2 1 1 2 3 3 3 1 Sec3 exocyst complex subunit TPR_MLP1_2 PF07926.12 ETO19041.1 - 0.0062 16.6 7.6 0.0084 16.2 7.6 1.2 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein MotY_N PF18393.1 ETO19041.1 - 0.041 14.0 0.2 0.052 13.7 0.2 1.1 1 0 0 1 1 1 0 MotY N-terminal domain Spore_III_AB PF09548.10 ETO19041.1 - 0.079 13.1 3.3 0.17 12.0 3.2 1.6 1 1 0 1 1 1 0 Stage III sporulation protein AB (spore_III_AB) DUF3499 PF12005.8 ETO19041.1 - 0.1 13.2 0.1 0.13 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3499) ATPase-cat_bd PF12156.8 ETO19042.1 - 3.4 8.5 7.4 0.23 12.2 0.7 2.5 2 0 0 2 2 2 0 Putative metal-binding domain of cation transport ATPase WD40 PF00400.32 ETO19043.1 - 3.5e-18 65.6 11.2 2.2e-08 34.6 0.1 5.7 6 0 0 6 6 6 3 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO19043.1 - 0.012 15.6 0.2 7.7 6.6 0.0 3.5 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 ETO19043.1 - 0.041 13.7 0.7 0.48 10.3 0.1 2.8 2 2 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO19043.1 - 0.063 11.8 0.1 2.7 6.4 0.0 2.7 3 0 0 3 3 3 0 Cytochrome D1 heme domain YugN PF08868.10 ETO19043.1 - 0.11 12.4 0.0 0.42 10.5 0.0 1.9 2 0 0 2 2 2 0 YugN-like family B_lectin PF01453.24 ETO19044.1 - 2.9e-07 31.0 0.3 0.00061 20.3 0.1 2.7 2 1 0 2 2 2 2 D-mannose binding lectin TLV_coat PF00429.19 ETO19044.1 - 0.066 11.9 1.0 0.15 10.7 0.9 1.5 2 0 0 2 2 2 0 ENV polyprotein (coat polyprotein) Ubiquitin_2 PF14560.6 ETO19045.1 - 0.021 15.3 0.0 9.2 6.8 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-like domain ubiquitin PF00240.23 ETO19045.1 - 0.047 13.5 0.2 10 6.0 0.0 2.4 2 0 0 2 2 2 0 Ubiquitin family DUF4614 PF15391.6 ETO19047.1 - 5.3 7.0 10.3 1.8 8.5 7.9 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Hid1 PF12722.7 ETO19047.1 - 9.7 4.2 7.3 10 4.1 7.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein TFIIA PF03153.13 ETO19048.1 - 0.028 14.4 33.1 0.041 13.9 33.1 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Utp14 PF04615.13 ETO19048.1 - 0.035 12.7 38.0 0.044 12.4 38.0 1.1 1 0 0 1 1 1 0 Utp14 protein DUF936 PF06075.12 ETO19048.1 - 1 8.2 38.6 1.3 7.8 38.6 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) Draxin PF15550.6 ETO19048.1 - 1.7 8.5 28.2 2.5 7.9 28.2 1.3 1 0 0 1 1 1 0 Draxin GREB1 PF15782.5 ETO19048.1 - 2.2 5.3 37.7 3 4.8 37.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SWI-SNF_Ssr4 PF08549.10 ETO19048.1 - 2.8 6.5 31.3 3.6 6.1 31.3 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Sporozoite_P67 PF05642.11 ETO19050.1 - 0.0052 14.9 5.6 0.0063 14.7 5.6 1.1 1 0 0 1 1 1 1 Sporozoite P67 surface antigen Cauli_DNA-bind PF03310.13 ETO19050.1 - 0.046 13.8 0.1 0.097 12.7 0.1 1.6 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein MIP-T3_C PF17749.1 ETO19050.1 - 0.25 11.3 2.3 0.61 10.0 0.0 2.3 2 1 1 3 3 3 0 Microtubule-binding protein MIP-T3 C-terminal region CorA PF01544.18 ETO19051.1 - 0.03 13.6 4.1 0.039 13.3 4.1 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein MbeD_MobD PF04899.12 ETO19051.1 - 0.13 12.3 9.9 0.051 13.7 4.4 2.3 1 1 1 2 2 2 0 MbeD/MobD like DUF1387 PF07139.11 ETO19051.1 - 2.3 7.9 25.5 2.4 7.8 25.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Rb_C PF08934.10 ETO19052.1 - 0.008 16.0 0.2 0.008 16.0 0.2 1.9 1 1 0 2 2 2 1 Rb C-terminal domain AP3D1 PF06375.11 ETO19052.1 - 0.016 15.5 11.0 0.025 14.8 11.0 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 fn3_5 PF06280.12 ETO19052.1 - 0.23 12.1 3.9 0.37 11.5 3.9 1.3 1 0 0 1 1 1 0 Fn3-like domain DUF3698 PF12479.8 ETO19052.1 - 3.8 8.1 6.1 7.8 7.1 6.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3698) Nop14 PF04147.12 ETO19053.1 - 0.0024 16.2 30.8 0.0029 15.9 30.8 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 ETO19053.1 - 0.012 13.9 22.1 0.015 13.6 22.1 1.2 1 0 0 1 1 1 0 CDC45-like protein BSP_II PF05432.11 ETO19053.1 - 0.035 13.8 25.6 0.046 13.4 25.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Presenilin PF01080.17 ETO19053.1 - 7.2 5.3 14.3 9 4.9 14.3 1.2 1 0 0 1 1 1 0 Presenilin HUN PF08729.10 ETO19054.1 - 2.1e-07 30.8 0.3 2.1e-07 30.8 0.3 2.9 3 0 0 3 3 3 1 HPC2 and ubinuclein domain CPSF100_C PF13299.6 ETO19054.1 - 0.53 10.5 21.9 0.12 12.5 1.5 3.0 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Hamartin PF04388.12 ETO19054.1 - 1.3 7.6 11.7 1.8 7.1 11.7 1.2 1 0 0 1 1 1 0 Hamartin protein Pex14_N PF04695.13 ETO19054.1 - 2.9 8.5 8.8 0.34 11.6 2.0 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region LAG1-DNAbind PF09271.11 ETO19054.1 - 8 7.1 11.4 95 3.6 11.4 2.6 1 1 0 1 1 1 0 LAG1, DNA binding Kelch_6 PF13964.6 ETO19056.1 - 4.2e-09 36.4 1.1 0.068 13.5 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO19056.1 - 0.00011 21.7 0.5 0.07 12.7 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO19056.1 - 0.00077 19.4 0.1 0.012 15.6 0.0 3.0 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO19056.1 - 0.0011 19.0 3.4 7.3 6.7 0.2 4.8 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 ETO19056.1 - 0.0015 18.5 1.8 0.9 9.6 0.0 4.5 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO19056.1 - 0.18 12.1 0.0 1.7 9.0 0.0 2.7 2 0 0 2 2 2 0 Galactose oxidase, central domain Peptidase_C14 PF00656.22 ETO19057.1 - 2.1e-10 41.0 0.2 4e-10 40.1 0.2 1.5 1 0 0 1 1 1 1 Caspase domain HemY_N PF07219.13 ETO19058.1 - 2.2 8.5 3.6 3.1 8.0 0.2 2.4 2 0 0 2 2 2 0 HemY protein N-terminus UCH PF00443.29 ETO19059.1 - 0.00036 20.1 5.1 0.00058 19.4 5.1 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO19059.1 - 0.0037 16.9 1.8 0.0086 15.7 1.8 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Mu-like_Com PF10122.9 ETO19059.1 - 0.011 15.2 0.0 0.028 13.9 0.0 1.7 1 0 0 1 1 1 0 Mu-like prophage protein Com Circo_capsid PF02443.15 ETO19059.1 - 0.021 14.4 1.9 0.024 14.2 1.9 1.1 1 0 0 1 1 1 0 Circovirus capsid protein Eapp_C PF10238.9 ETO19059.1 - 0.028 14.5 2.3 0.047 13.8 2.3 1.3 1 0 0 1 1 1 0 E2F-associated phosphoprotein Peptidase_C98 PF15499.6 ETO19059.1 - 0.13 11.7 1.6 0.15 11.5 1.6 1.0 1 0 0 1 1 1 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase TT_ORF1 PF02956.14 ETO19059.1 - 0.55 8.8 6.9 0.64 8.6 6.9 1.1 1 0 0 1 1 1 0 TT viral orf 1 Sec62 PF03839.16 ETO19059.1 - 0.91 9.0 3.9 0.95 8.9 3.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 LapA_dom PF06305.11 ETO19059.1 - 3.1 7.7 4.0 5.6 6.9 4.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Pannexin_like PF12534.8 ETO19060.1 - 0.0095 15.1 0.4 0.011 14.8 0.4 1.2 1 0 0 1 1 1 1 Pannexin-like TM region of LRRC8 NAM-associated PF14303.6 ETO19060.1 - 0.028 15.1 8.7 0.036 14.8 8.7 1.1 1 0 0 1 1 1 0 No apical meristem-associated C-terminal domain DUF1754 PF08555.10 ETO19060.1 - 0.048 14.4 10.8 0.075 13.8 10.8 1.3 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) RGS PF00615.19 ETO19061.1 - 0.0014 18.9 4.1 0.0039 17.4 4.1 1.7 1 1 0 1 1 1 1 Regulator of G protein signaling domain Phage_Gp15 PF06854.11 ETO19061.1 - 0.0077 16.2 0.6 0.012 15.6 0.6 1.3 1 0 0 1 1 1 1 Bacteriophage Gp15 protein DNA_pol3_a_NII PF11490.8 ETO19061.1 - 0.04 13.8 3.3 0.056 13.3 3.3 1.2 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II DUF4434 PF14488.6 ETO19061.1 - 0.083 12.9 0.6 0.11 12.5 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4434) Neur_chan_LBD PF02931.23 ETO19062.1 - 0.00011 21.7 0.5 0.00018 21.1 0.5 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain Ogr_Delta PF04606.12 ETO19064.1 - 0.041 13.8 0.4 0.12 12.4 0.4 1.7 1 0 0 1 1 1 0 Ogr/Delta-like zinc finger AgrB PF04647.15 ETO19065.1 - 0.052 12.9 2.6 2.6 7.3 1.6 2.4 1 1 1 2 2 2 0 Accessory gene regulator B Raptor_N PF14538.6 ETO19068.1 - 5.6e-27 94.5 0.0 9.6e-27 93.7 0.0 1.4 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain fn3 PF00041.21 ETO19069.1 - 0.00078 19.7 0.7 0.0053 17.1 0.1 2.4 2 0 0 2 2 2 1 Fibronectin type III domain NAD_binding_6 PF08030.12 ETO19071.1 - 0.00091 19.4 0.1 0.062 13.4 0.1 2.4 1 1 0 1 1 1 1 Ferric reductase NAD binding domain DUF4820 PF16091.5 ETO19071.1 - 0.089 12.1 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) AAA_22 PF13401.6 ETO19072.1 - 7.6e-05 23.0 0.1 0.00042 20.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_14 PF13173.6 ETO19072.1 - 0.00029 20.9 0.1 0.0016 18.5 0.0 2.4 2 0 0 2 2 2 1 AAA domain IstB_IS21 PF01695.17 ETO19072.1 - 0.0059 16.4 0.0 0.015 15.0 0.0 1.7 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_16 PF13191.6 ETO19072.1 - 0.027 14.8 0.1 0.45 10.9 0.0 2.4 1 1 0 2 2 2 0 AAA ATPase domain ATPase_2 PF01637.18 ETO19072.1 - 0.036 14.0 0.0 0.67 9.8 0.0 2.5 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea CPT PF07931.12 ETO19072.1 - 0.07 13.0 0.2 0.19 11.6 0.0 1.8 2 0 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein Stealth_CR4 PF17103.5 ETO19072.1 - 0.08 12.8 0.8 0.33 10.9 0.2 2.4 2 0 0 2 2 2 0 Stealth protein CR4, conserved region 4 Com_YlbF PF06133.11 ETO19072.1 - 0.63 10.7 5.0 0.27 11.9 0.6 2.6 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA Enkurin PF13864.6 ETO19072.1 - 2.5 8.6 6.0 32 5.1 0.1 3.0 2 0 0 2 2 2 0 Calmodulin-binding FANCI_S3 PF14677.6 ETO19073.1 - 0.012 15.3 2.0 2.1 8.0 0.1 2.5 3 0 0 3 3 3 0 FANCI solenoid 3 Glyco_hydro_2 PF00703.21 ETO19073.1 - 0.61 10.8 5.7 0.15 12.7 1.5 2.0 2 0 0 2 2 2 0 Glycosyl hydrolases family 2 WD40 PF00400.32 ETO19075.1 - 0.026 15.4 0.5 0.12 13.3 0.1 2.4 2 0 0 2 2 2 0 WD domain, G-beta repeat CaM-KIIN PF15170.6 ETO19075.1 - 0.033 14.3 0.2 2.4 8.3 0.0 2.4 2 0 0 2 2 2 0 Calcium/calmodulin-dependent protein kinase II inhibitor SPATIAL PF15256.6 ETO19075.1 - 0.43 10.9 8.5 0.31 11.3 6.8 1.6 1 1 0 1 1 1 0 SPATIAL RCC1_2 PF13540.6 ETO19076.1 - 0.0025 17.6 9.0 0.0043 16.8 0.3 3.3 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat Sulfate_transp PF00916.20 ETO19076.1 - 0.075 11.8 0.1 0.12 11.2 0.1 1.2 1 0 0 1 1 1 0 Sulfate permease family PH PF00169.29 ETO19076.1 - 0.16 12.5 1.8 0.21 12.1 0.1 2.1 2 0 0 2 2 2 0 PH domain 7TM-7TMR_HD PF07698.11 ETO19076.1 - 0.22 11.3 3.4 0.36 10.6 3.4 1.3 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase SNARE PF05739.19 ETO19076.1 - 0.95 9.5 8.0 2.2 8.4 8.0 1.6 1 0 0 1 1 1 0 SNARE domain Mpp10 PF04006.12 ETO19076.1 - 9.2 4.6 27.3 0.019 13.5 10.3 2.2 2 0 0 2 2 2 0 Mpp10 protein Trp_dioxygenase PF03301.13 ETO19078.1 - 7.1e-37 127.5 1.9 6.7e-22 78.3 0.1 2.1 2 0 0 2 2 2 2 Tryptophan 2,3-dioxygenase rRNA_proc-arch PF13234.6 ETO19079.1 - 0.022 14.7 0.1 0.042 13.8 0.1 1.4 1 0 0 1 1 1 0 rRNA-processing arch domain Zn_clus PF00172.18 ETO19080.1 - 6.4 7.0 9.9 7.9 6.7 6.4 2.6 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain MtlR PF05068.12 ETO19083.1 - 0.016 15.2 2.0 0.018 15.0 0.2 2.0 2 0 0 2 2 2 0 Mannitol repressor OmpH PF03938.14 ETO19083.1 - 0.72 10.2 11.6 1.5 9.2 11.6 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Insulin_TMD PF17870.1 ETO19083.1 - 1.5 9.0 4.8 2.5 8.2 0.3 3.1 3 0 0 3 3 3 0 Insulin receptor trans-membrane segment IU_nuc_hydro PF01156.19 ETO19084.1 - 2e-14 53.9 0.0 2.5e-14 53.6 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase PH PF00169.29 ETO19085.1 - 8.7e-05 23.0 0.0 0.0034 17.9 0.0 2.5 2 0 0 2 2 2 1 PH domain RhoGEF PF00621.20 ETO19085.1 - 0.014 15.7 0.1 0.035 14.4 0.1 1.6 1 0 0 1 1 1 0 RhoGEF domain Stm1_N PF09598.10 ETO19085.1 - 0.71 10.8 6.8 2.4 9.1 6.8 1.9 1 0 0 1 1 1 0 Stm1 TPR_12 PF13424.6 ETO19086.1 - 0.0012 19.1 0.9 0.17 12.2 0.4 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat CdiI_2 PF18593.1 ETO19086.1 - 0.047 14.3 0.0 0.25 12.0 0.0 2.0 2 0 0 2 2 2 0 CdiI immunity protein GDE_C PF06202.14 ETO19086.1 - 0.076 11.9 0.1 0.083 11.8 0.1 1.2 1 0 0 1 1 1 0 Amylo-alpha-1,6-glucosidase Herpes_LMP1 PF05297.11 ETO19087.1 - 1.1 8.3 10.1 1.7 7.8 10.1 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DAGK_acc PF00609.19 ETO19088.1 - 6.7e-34 117.5 0.0 1.3e-33 116.6 0.0 1.5 1 1 0 1 1 1 1 Diacylglycerol kinase accessory domain Pkinase PF00069.25 ETO19089.1 - 6e-05 22.5 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain RIFIN PF02009.16 ETO19089.1 - 0.51 10.2 8.4 0.74 9.7 8.4 1.2 1 0 0 1 1 1 0 Rifin Mucin PF01456.17 ETO19089.1 - 3.2 7.8 30.4 0.27 11.2 16.4 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein WD40 PF00400.32 ETO19090.1 - 1.8e-11 44.4 11.3 2.4e-06 28.1 0.3 4.7 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19090.1 - 3.8e-05 23.9 5.0 0.25 11.7 0.7 3.9 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Prion PF00377.18 ETO19090.1 - 0.049 13.5 0.1 0.15 11.9 0.0 1.8 2 0 0 2 2 2 0 Prion/Doppel alpha-helical domain Bap31_Bap29_C PF18035.1 ETO19090.1 - 1.4 8.9 3.7 27 4.8 0.0 3.0 4 0 0 4 4 4 0 Bap31/Bap29 cytoplasmic coiled-coil domain WD40 PF00400.32 ETO19092.1 - 2.3e-43 145.3 8.5 3.3e-07 30.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19092.1 - 1.3e-22 79.9 3.2 0.0012 19.0 0.2 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19092.1 - 2.4e-14 53.0 0.0 0.0091 15.0 0.0 5.2 2 2 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO19092.1 - 6.3e-13 49.0 0.1 9.7e-07 28.8 0.1 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO19092.1 - 1.1e-08 34.8 7.1 0.51 10.3 0.0 7.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO19092.1 - 4e-06 26.4 0.1 0.022 14.1 0.0 3.5 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO19092.1 - 1.2e-05 24.2 1.3 0.24 10.0 0.0 3.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO19092.1 - 0.00015 21.2 3.6 1.7 7.9 0.2 4.6 2 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO19092.1 - 0.00016 20.5 0.0 3.1 6.5 0.0 4.7 1 1 6 7 7 7 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_2 PF13360.6 ETO19092.1 - 0.00033 20.3 0.2 0.0042 16.7 0.2 2.4 1 1 0 1 1 1 1 PQQ-like domain Cytochrom_D1 PF02239.16 ETO19092.1 - 0.0012 17.5 0.1 0.68 8.4 0.0 2.8 1 1 1 2 2 2 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO19092.1 - 0.016 14.2 1.4 1.2 8.0 0.0 3.4 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO19092.1 - 0.032 14.3 0.5 16 5.6 0.1 3.7 2 1 1 4 4 4 0 Family of unknown function (DUF5570) DASH_Ask1 PF08655.10 ETO19093.1 - 0.021 14.7 1.5 0.029 14.3 0.2 1.9 2 0 0 2 2 2 0 DASH complex subunit Ask1 AdoHcyase_NAD PF00670.21 ETO19093.1 - 0.26 11.3 1.0 0.95 9.5 0.1 2.0 1 1 0 2 2 2 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain Adeno_knob PF00541.17 ETO19094.1 - 0.092 12.5 1.8 0.3 10.8 0.6 2.0 2 0 0 2 2 2 0 Adenoviral fibre protein (knob domain) ubiquitin PF00240.23 ETO19095.1 - 2e-07 30.6 0.4 5.1e-07 29.4 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin family WD40 PF00400.32 ETO19097.1 - 2.8e-19 69.1 16.5 3.8e-06 27.5 1.0 4.7 5 2 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19097.1 - 1.2e-05 25.5 2.8 0.18 12.1 0.2 4.0 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19097.1 - 0.0026 16.5 4.4 1.5 7.4 0.1 3.4 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Peptidase_C14 PF00656.22 ETO19098.1 - 1.2e-05 25.5 0.3 2.1e-05 24.6 0.3 1.3 1 0 0 1 1 1 1 Caspase domain fn3 PF00041.21 ETO19099.1 - 2.9e-07 30.7 0.0 2.5e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 Fibronectin type III domain SID-1_RNA_chan PF13965.6 ETO19099.1 - 0.00042 18.9 1.2 0.00055 18.5 1.2 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 AF-4 PF05110.13 ETO19099.1 - 0.0016 16.6 12.3 0.0019 16.4 12.3 1.1 1 0 0 1 1 1 1 AF-4 proto-oncoprotein SpoIIIAH PF12685.7 ETO19099.1 - 0.0018 18.1 0.7 0.0023 17.8 0.7 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein FAM176 PF14851.6 ETO19099.1 - 0.0032 17.2 0.7 0.0049 16.5 0.7 1.4 1 0 0 1 1 1 1 FAM176 family Zip PF02535.22 ETO19099.1 - 0.0033 16.7 0.1 0.004 16.4 0.1 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF4834 PF16118.5 ETO19099.1 - 0.024 15.6 0.0 0.052 14.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PKD_3 PF16820.5 ETO19099.1 - 0.025 14.3 0.0 0.049 13.4 0.0 1.5 1 0 0 1 1 1 0 PKD-like domain TLP-20 PF06088.11 ETO19099.1 - 0.028 14.3 2.6 0.04 13.8 2.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Hydin_ADK PF17213.3 ETO19099.1 - 0.033 14.5 0.4 0.043 14.1 0.4 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Nop14 PF04147.12 ETO19099.1 - 0.065 11.4 10.6 0.074 11.3 10.6 1.0 1 0 0 1 1 1 0 Nop14-like family DUF4614 PF15391.6 ETO19099.1 - 0.11 12.5 7.4 0.15 12.0 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Trypan_PARP PF05887.11 ETO19099.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pur_ac_phosph_N PF16656.5 ETO19099.1 - 0.19 12.3 3.8 0.29 11.7 3.8 1.4 1 1 0 1 1 1 0 Purple acid Phosphatase, N-terminal domain SURF2 PF05477.11 ETO19099.1 - 0.24 11.0 10.3 0.31 10.7 10.3 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF913 PF06025.12 ETO19099.1 - 0.59 9.1 5.0 0.77 8.7 5.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CCDC106 PF15794.5 ETO19099.1 - 1.2 8.8 12.1 1.7 8.3 12.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 MCM_bind PF09739.9 ETO19099.1 - 1.6 7.1 7.9 2 6.8 7.9 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor RPN2_C PF18004.1 ETO19099.1 - 1.9 8.4 11.9 3 7.7 11.9 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CobT PF06213.12 ETO19099.1 - 2.1 7.6 12.2 2.7 7.3 12.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 ETO19099.1 - 2.9 6.1 13.7 3.7 5.7 13.7 1.0 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 ETO19099.1 - 3.7 7.6 9.7 6.4 6.8 9.7 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal NPR3 PF03666.13 ETO19099.1 - 4 6.1 12.0 5 5.8 12.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AAA PF00004.29 ETO19100.1 - 4.4e-53 179.2 0.1 1.7e-40 138.5 0.1 2.7 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO19100.1 - 9e-11 41.4 0.1 2.6e-10 39.9 0.1 1.8 1 0 0 1 1 1 1 AAA+ lid domain TIP49 PF06068.13 ETO19100.1 - 5.8e-08 32.3 0.0 0.01 15.1 0.0 2.4 2 0 0 2 2 2 2 TIP49 P-loop domain AAA_16 PF13191.6 ETO19100.1 - 2.5e-07 31.3 0.1 0.002 18.6 0.0 3.5 2 1 1 3 3 3 2 AAA ATPase domain AAA_22 PF13401.6 ETO19100.1 - 3.6e-07 30.6 0.9 0.0013 19.1 0.2 4.3 2 2 1 3 3 3 1 AAA domain AAA_2 PF07724.14 ETO19100.1 - 1.3e-06 28.6 0.1 5.7e-06 26.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) IstB_IS21 PF01695.17 ETO19100.1 - 8.1e-06 25.7 0.0 0.018 14.7 0.0 2.6 2 0 0 2 2 2 2 IstB-like ATP binding protein TsaE PF02367.17 ETO19100.1 - 5.2e-05 23.2 0.0 0.44 10.6 0.0 2.8 3 0 0 3 3 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETO19100.1 - 0.00011 22.6 0.0 0.13 12.7 0.0 3.0 2 0 0 2 2 2 1 RNA helicase AAA_5 PF07728.14 ETO19100.1 - 0.00017 21.6 0.0 0.0017 18.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETO19100.1 - 0.0002 21.9 0.1 0.23 12.0 0.0 3.0 3 0 0 3 3 2 1 AAA domain AAA_7 PF12775.7 ETO19100.1 - 0.0003 20.3 0.1 0.028 13.9 0.1 2.5 2 0 0 2 2 2 1 P-loop containing dynein motor region ATPase PF06745.13 ETO19100.1 - 0.0004 19.8 0.5 0.22 10.9 0.1 3.0 3 0 0 3 3 3 1 KaiC Mg_chelatase PF01078.21 ETO19100.1 - 0.00067 19.1 0.0 0.0028 17.1 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_24 PF13479.6 ETO19100.1 - 0.0018 18.0 0.4 0.0091 15.7 0.0 2.3 3 0 0 3 3 2 1 AAA domain ABC_tran PF00005.27 ETO19100.1 - 0.0021 18.6 0.2 0.069 13.7 0.1 3.2 3 1 0 3 3 3 1 ABC transporter AAA_33 PF13671.6 ETO19100.1 - 0.0026 17.9 0.0 0.14 12.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ETO19100.1 - 0.0033 17.2 0.0 0.1 12.3 0.0 2.7 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_25 PF13481.6 ETO19100.1 - 0.0095 15.5 1.4 1.4 8.5 0.0 3.5 2 2 1 3 3 3 1 AAA domain NACHT PF05729.12 ETO19100.1 - 0.012 15.5 0.0 1.1 9.1 0.0 3.0 2 1 0 2 2 2 0 NACHT domain IPT PF01745.16 ETO19100.1 - 0.013 14.9 0.8 1.3 8.3 0.1 3.0 3 0 0 3 3 3 0 Isopentenyl transferase Molydop_binding PF01568.21 ETO19100.1 - 0.023 14.7 0.0 0.049 13.7 0.0 1.5 1 0 0 1 1 1 0 Molydopterin dinucleotide binding domain Sigma54_activat PF00158.26 ETO19100.1 - 0.028 14.1 0.0 0.78 9.4 0.0 2.4 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_19 PF13245.6 ETO19100.1 - 0.033 14.5 0.2 0.13 12.6 0.2 2.2 1 1 0 1 1 1 0 AAA domain Rad17 PF03215.15 ETO19100.1 - 0.04 13.8 0.1 11 5.8 0.0 3.0 3 0 0 3 3 3 0 Rad17 P-loop domain TniB PF05621.11 ETO19100.1 - 0.07 12.5 0.2 6.3 6.2 0.0 3.3 2 1 1 3 3 3 0 Bacterial TniB protein AAA_30 PF13604.6 ETO19100.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF2688 PF10892.8 ETO19101.1 - 0.091 12.2 0.1 1.7 8.1 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2688) NosD PF05048.13 ETO19102.1 - 7e-31 107.3 42.8 2.7e-26 92.3 38.4 2.7 1 1 1 2 2 2 2 Periplasmic copper-binding protein (NosD) Beta_helix PF13229.6 ETO19102.1 - 1.3e-18 67.3 92.5 1.2e-09 38.2 20.9 3.9 1 1 3 4 4 4 3 Right handed beta helix region TPR_12 PF13424.6 ETO19103.1 - 7.5e-89 292.1 25.5 2.4e-18 66.2 0.1 7.1 3 2 3 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO19103.1 - 4.1e-72 236.3 0.9 3.1e-08 33.2 0.0 10.0 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 ETO19103.1 - 3.2e-55 181.8 53.3 6.1e-08 32.2 5.2 10.6 10 1 1 11 11 11 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO19103.1 - 7.8e-51 166.4 17.7 6.1e-06 25.9 0.0 9.6 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO19103.1 - 4.9e-46 151.2 40.5 4e-06 26.5 2.4 10.4 10 1 0 10 10 10 10 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19103.1 - 1.1e-40 134.5 52.9 8.9e-06 25.5 0.2 10.1 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_6 PF13174.6 ETO19103.1 - 5.8e-15 54.9 16.0 0.66 10.7 0.0 9.4 10 0 0 10 10 9 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO19103.1 - 1.6e-14 53.3 48.8 0.03 14.0 5.0 12.2 9 5 4 13 13 13 7 TPR repeat TPR_14 PF13428.6 ETO19103.1 - 8.6e-13 47.9 0.2 4.4 8.4 0.0 8.9 7 3 2 9 9 9 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO19103.1 - 1.2e-12 47.1 9.7 0.02 14.4 0.0 7.9 8 1 0 8 8 8 4 SHNi-TPR TPR_17 PF13431.6 ETO19103.1 - 1.7e-12 46.8 17.0 0.28 11.6 0.1 10.1 8 2 1 9 9 9 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO19103.1 - 1.8e-08 34.9 0.2 9.6 7.0 0.0 6.8 7 2 0 7 7 7 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO19103.1 - 1.5e-06 28.6 4.2 0.15 12.6 0.1 5.3 6 1 0 6 6 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO19103.1 - 4.1e-06 26.4 0.0 0.002 17.6 0.0 3.2 2 1 0 3 3 3 1 MalT-like TPR region DUF5113 PF17140.4 ETO19103.1 - 0.00028 20.7 30.1 2.8 7.7 0.8 8.1 7 2 1 9 9 9 1 Domain of unknown function (DUF5113) MIT PF04212.18 ETO19103.1 - 0.0011 19.0 35.6 2.5 8.3 1.0 8.7 6 3 4 10 10 9 3 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 ETO19103.1 - 0.0055 16.2 12.2 0.25 10.8 0.2 4.1 3 2 2 6 6 6 2 Meiosis protein SPO22/ZIP4 like TPR_3 PF07720.12 ETO19103.1 - 0.0075 16.2 1.5 0.0075 16.2 1.5 7.1 9 0 0 9 9 6 1 Tetratricopeptide repeat DUF2262 PF10020.9 ETO19103.1 - 0.026 14.9 0.4 17 5.8 0.1 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2262) MamL-1 PF09596.10 ETO19103.1 - 0.038 14.2 0.0 37 4.7 0.0 3.9 4 0 0 4 4 4 0 MamL-1 domain TPR_5 PF12688.7 ETO19103.1 - 0.072 13.3 1.3 36 4.6 0.1 4.2 3 1 2 5 5 4 0 Tetratrico peptide repeat ANAPC3 PF12895.7 ETO19103.1 - 0.09 13.0 20.5 0.75 10.1 1.9 5.1 2 2 3 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 mit_SMPDase PF14724.6 ETO19103.1 - 0.1 10.5 1.2 2.9 5.7 0.0 2.7 1 1 2 3 3 3 0 Mitochondrial-associated sphingomyelin phosphodiesterase RPN7 PF10602.9 ETO19103.1 - 0.71 9.5 21.5 16 5.1 0.4 6.1 3 3 2 6 6 6 0 26S proteasome subunit RPN7 DUF3856 PF12968.7 ETO19103.1 - 3.1 7.9 6.9 50 3.9 0.2 4.9 2 2 3 5 5 5 0 Domain of Unknown Function (DUF3856) ATP-synt_E_2 PF08112.11 ETO19103.1 - 5.1 7.5 5.9 21 5.5 0.1 4.6 7 0 0 7 7 5 0 ATP synthase epsilon subunit Mad3_BUB1_I PF08311.12 ETO19103.1 - 8 6.5 9.1 12 5.9 0.2 4.0 4 0 0 4 4 4 0 Mad3/BUB1 homology region 1 NICE-3 PF07406.11 ETO19104.1 - 0.088 12.8 0.0 0.67 9.9 0.0 2.0 2 0 0 2 2 2 0 NICE-3 protein DUF962 PF06127.11 ETO19107.1 - 0.099 12.7 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF962) WD40 PF00400.32 ETO19108.1 - 8.6e-40 134.0 23.1 2.3e-06 28.2 0.3 7.4 7 3 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19108.1 - 2.1e-12 47.2 1.1 0.019 15.2 0.0 5.3 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19108.1 - 2e-11 43.3 7.2 0.0012 17.5 0.2 5.1 3 3 0 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO19108.1 - 3.8e-08 33.0 3.2 6.2e-05 22.5 0.1 3.5 3 1 0 3 3 3 2 WD40-like domain TIG_plexin PF17960.1 ETO19109.1 - 0.01 15.8 0.1 0.029 14.3 0.0 1.8 1 1 1 2 2 2 1 TIG domain ProQ PF04352.13 ETO19109.1 - 0.41 10.5 3.7 7.6 6.5 0.1 2.8 2 1 1 3 3 3 0 ProQ/FINO family Acyl-CoA_dh_N PF02771.16 ETO19110.1 - 1.3e-24 87.0 0.0 2.5e-24 86.1 0.0 1.5 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain DUF4672 PF15716.5 ETO19110.1 - 0.029 14.0 0.5 0.053 13.1 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) CCAP PF11105.8 ETO19110.1 - 0.066 13.2 0.6 0.096 12.6 0.6 1.2 1 0 0 1 1 1 0 Arthropod cardioacceleratory peptide 2a CAP_GLY PF01302.25 ETO19111.1 - 1.2e-09 38.0 0.0 2e-09 37.4 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain Golgin_A5 PF09787.9 ETO19111.1 - 0.0065 16.0 5.4 0.0088 15.5 5.4 1.1 1 0 0 1 1 1 1 Golgin subfamily A member 5 AATF-Che1 PF13339.6 ETO19111.1 - 0.0085 16.8 4.8 0.014 16.1 4.8 1.3 1 0 0 1 1 1 1 Apoptosis antagonizing transcription factor DUF4315 PF14193.6 ETO19111.1 - 0.029 14.4 4.7 0.45 10.6 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) BORCS7 PF16088.5 ETO19111.1 - 0.056 13.7 5.6 0.1 12.9 5.6 1.4 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 7 TMPIT PF07851.13 ETO19111.1 - 0.33 10.2 3.8 0.49 9.6 3.8 1.2 1 0 0 1 1 1 0 TMPIT-like protein MCU PF04678.13 ETO19111.1 - 0.63 10.1 3.5 0.97 9.5 3.5 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter YgaB PF14182.6 ETO19111.1 - 0.85 10.1 9.0 1.5 9.3 9.0 1.3 1 0 0 1 1 1 0 YgaB-like protein GPS2_interact PF15784.5 ETO19111.1 - 5.6 7.5 13.1 0.73 10.3 3.7 2.5 1 1 1 2 2 2 0 G-protein pathway suppressor 2-interacting domain Kelch_4 PF13418.6 ETO19113.1 - 0.03 14.3 0.0 0.063 13.3 0.0 1.6 1 1 1 2 2 2 0 Galactose oxidase, central domain Asp23 PF03780.13 ETO19113.1 - 0.041 14.3 0.3 0.055 13.9 0.3 1.2 1 0 0 1 1 1 0 Asp23 family, cell envelope-related function Kelch_6 PF13964.6 ETO19113.1 - 0.071 13.4 0.8 3.4 8.1 0.2 2.2 1 1 1 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO19113.1 - 0.12 12.4 0.3 16 5.7 0.0 2.2 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO19114.1 - 2.3e-13 50.4 8.1 6.7e-05 23.6 0.1 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO19114.1 - 0.0068 15.1 0.1 3.5 6.1 0.0 2.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO19114.1 - 0.0077 16.5 0.3 1.8 8.9 0.1 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Ank_2 PF12796.7 ETO19115.1 - 0.0012 19.4 0.1 0.0036 17.9 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Methyltransf_11 PF08241.12 ETO19117.1 - 2e-06 28.3 0.1 6.3e-06 26.7 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO19117.1 - 5.6e-06 27.0 0.2 3.9e-05 24.3 0.2 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO19117.1 - 0.0077 16.1 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO19117.1 - 0.074 13.8 0.3 0.25 12.1 0.0 2.2 2 0 0 2 2 2 0 Methyltransferase domain DUF2817 PF10994.8 ETO19118.1 - 1.8e-42 146.0 0.0 2e-28 99.8 0.0 3.1 2 1 0 2 2 2 2 Protein of unknown function (DUF2817) AstE_AspA PF04952.14 ETO19118.1 - 0.14 11.2 0.0 0.22 10.6 0.0 1.3 1 0 0 1 1 1 0 Succinylglutamate desuccinylase / Aspartoacylase family DUF957 PF06117.11 ETO19118.1 - 0.24 11.0 3.3 0.57 9.8 0.6 2.2 2 0 0 2 2 2 0 Enterobacterial protein of unknown function (DUF957) EF-hand_1 PF00036.32 ETO19119.1 - 3.1e-08 32.6 0.4 2.6e-05 23.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO19119.1 - 3.4e-07 30.6 1.0 6.5e-07 29.7 0.4 1.8 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO19119.1 - 6.4e-06 25.7 0.0 0.0033 17.2 0.0 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO19119.1 - 0.00034 20.0 0.2 0.11 12.1 0.0 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO19119.1 - 0.00084 19.1 0.7 0.003 17.4 0.7 1.9 1 1 0 1 1 1 1 EF-hand domain pair SpoVIF PF14069.6 ETO19119.1 - 0.035 13.9 0.7 0.11 12.3 0.1 2.0 2 0 0 2 2 2 0 Stage VI sporulation protein F WD40 PF00400.32 ETO19121.1 - 1e-44 149.6 12.8 8.7e-11 42.2 0.4 6.6 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19121.1 - 2.1e-20 72.8 1.0 0.0021 18.3 0.1 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO19121.1 - 9.1e-11 41.6 1.5 7.5e-05 22.2 0.5 3.4 2 1 2 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO19121.1 - 1.8e-08 33.7 0.1 0.39 9.6 0.0 4.9 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO19121.1 - 1.1e-07 30.9 0.8 0.06 12.0 0.0 4.1 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO19121.1 - 0.0016 17.1 0.1 0.31 9.5 0.0 2.4 1 1 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO19121.1 - 0.0045 16.9 1.0 2.2 8.3 0.0 3.9 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO19121.1 - 0.018 15.1 0.7 8.4 6.5 0.0 3.6 2 1 1 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DUF5046 PF16465.5 ETO19121.1 - 0.04 13.4 0.0 1.2 8.5 0.0 2.7 1 1 1 3 3 3 0 Domain of unknown function (DUF5046) WD40 PF00400.32 ETO19122.1 - 1.7e-06 28.7 0.2 0.007 17.2 0.0 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat AbrB PF05145.12 ETO19123.1 - 0.0042 16.1 0.1 0.006 15.6 0.1 1.2 1 0 0 1 1 1 1 Transition state regulatory protein AbrB DUF2207 PF09972.9 ETO19123.1 - 0.04 12.7 0.6 0.056 12.2 0.2 1.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF998 PF06197.13 ETO19123.1 - 0.05 13.2 0.1 9.8 5.7 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF998) ANAPC_CDC26 PF10471.9 ETO19124.1 - 0.033 15.0 7.4 0.033 15.0 7.4 3.8 5 0 0 5 5 5 0 Anaphase-promoting complex APC subunit CDC26 DUF702 PF05142.12 ETO19124.1 - 0.035 14.6 1.4 0.035 14.6 1.4 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF702) MscS_TM PF12794.7 ETO19124.1 - 0.71 8.7 1.2 1.1 8.0 1.2 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 CRAL_TRIO PF00650.20 ETO19125.1 - 2.7e-10 40.2 0.0 3.7e-10 39.8 0.0 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain DUF4519 PF15012.6 ETO19126.1 - 0.16 12.1 0.2 0.16 12.1 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) zf-C2H2 PF00096.26 ETO19128.1 - 0.24 12.0 16.2 0.39 11.3 1.1 3.8 3 0 0 3 3 3 0 Zinc finger, C2H2 type Arabino_trans_C PF14896.6 ETO19129.1 - 0.15 11.0 1.0 0.16 11.0 1.0 1.0 1 0 0 1 1 1 0 EmbC C-terminal domain DUF719 PF05334.13 ETO19129.1 - 0.25 11.5 7.4 0.25 11.5 7.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF719) DUF3464 PF11947.8 ETO19129.1 - 0.64 9.8 3.0 0.62 9.8 3.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 EIIBC-GUT_N PF03612.14 ETO19129.1 - 0.69 9.6 6.3 0.69 9.6 6.3 1.0 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus TMEM144 PF07857.12 ETO19129.1 - 0.74 8.7 1.4 0.85 8.5 1.4 1.0 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters Connexin PF00029.19 ETO19129.1 - 0.77 9.5 6.2 0.85 9.3 6.2 1.2 1 0 0 1 1 1 0 Connexin XAP5 PF04921.14 ETO19129.1 - 1.1 9.1 11.3 1 9.1 11.3 1.0 1 0 0 1 1 1 0 XAP5, circadian clock regulator DUF4471 PF14740.6 ETO19129.1 - 1.6 7.9 6.8 1.4 8.0 6.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Sec62 PF03839.16 ETO19129.1 - 1.7 8.1 3.6 1.7 8.1 3.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 CPSF100_C PF13299.6 ETO19129.1 - 1.9 8.7 9.6 1.9 8.7 9.6 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DAP PF15228.6 ETO19129.1 - 2.2 9.5 4.5 2.9 9.1 4.5 1.3 1 0 0 1 1 1 0 Death-associated protein RNA_pol_Rpc4 PF05132.14 ETO19129.1 - 2.4 8.6 8.7 2.5 8.5 8.7 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 DNA_pol_phi PF04931.13 ETO19129.1 - 3 5.8 33.0 3 5.8 33.0 1.0 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO19129.1 - 3.1 6.5 8.2 3.1 6.5 8.2 1.0 1 0 0 1 1 1 0 Presenilin DUF5523 PF17661.1 ETO19129.1 - 3.3 7.3 21.4 3.4 7.3 21.4 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5523) AIF_C PF14721.6 ETO19129.1 - 3.4 8.0 6.6 3.6 8.0 6.6 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term D123 PF07065.14 ETO19129.1 - 3.4 6.7 8.1 3.2 6.8 8.1 1.1 1 0 0 1 1 1 0 D123 SURF2 PF05477.11 ETO19129.1 - 3.4 7.3 12.0 3.3 7.3 12.0 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Zip PF02535.22 ETO19129.1 - 3.6 6.7 6.9 3.6 6.7 6.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Afi1 PF07792.12 ETO19129.1 - 4.1 7.9 9.6 4.2 7.9 9.6 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4746 PF15928.5 ETO19129.1 - 4.2 6.7 23.0 4.4 6.6 23.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Ureide_permease PF07168.11 ETO19129.1 - 4.4 6.0 5.3 4.1 6.0 5.3 1.0 1 0 0 1 1 1 0 Ureide permease Nucleoside_tran PF01733.18 ETO19129.1 - 4.5 6.6 4.0 4.6 6.5 4.0 1.0 1 0 0 1 1 1 0 Nucleoside transporter FHIPEP PF00771.20 ETO19129.1 - 4.5 5.6 5.1 4.7 5.6 5.1 1.0 1 0 0 1 1 1 0 FHIPEP family TRAP_alpha PF03896.16 ETO19129.1 - 5 6.2 19.0 5 6.2 19.0 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Vfa1 PF08432.10 ETO19129.1 - 5.4 7.3 12.0 5.4 7.3 12.0 1.0 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 THOC2_N PF16134.5 ETO19129.1 - 5.4 5.5 10.4 5.5 5.5 10.4 1.0 1 0 0 1 1 1 0 THO complex subunit 2 N-terminus Smg4_UPF3 PF03467.15 ETO19129.1 - 5.4 7.0 10.6 5.7 6.9 10.6 1.1 1 0 0 1 1 1 0 Smg-4/UPF3 family Folate_carrier PF01770.18 ETO19129.1 - 5.6 5.6 4.1 5.4 5.6 4.1 1.0 1 0 0 1 1 1 0 Reduced folate carrier SpoIIP PF07454.11 ETO19129.1 - 5.7 6.3 12.1 5.7 6.3 12.1 1.0 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Sigma70_ner PF04546.13 ETO19129.1 - 5.9 6.7 22.6 5.8 6.7 22.6 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2052 PF09747.9 ETO19129.1 - 6.4 6.9 23.0 7.5 6.6 23.0 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) GNAT_acetyltr_2 PF13718.6 ETO19129.1 - 6.9 6.0 6.4 6.7 6.0 6.4 1.0 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Nop53 PF07767.11 ETO19129.1 - 7.5 5.8 23.4 7.4 5.8 23.4 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF913 PF06025.12 ETO19129.1 - 9 5.2 9.3 8.5 5.2 9.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RPA43_OB PF17875.1 ETO19129.1 - 9.7 6.8 11.2 11 6.7 11.2 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Tim54 PF11711.8 ETO19129.1 - 9.9 4.8 14.4 10 4.8 14.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DEAD PF00270.29 ETO19130.1 - 1.2e-19 70.7 0.2 1.9e-19 70.1 0.2 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO19130.1 - 0.0092 16.0 0.0 0.0092 16.0 0.0 1.9 1 1 1 2 2 2 1 Type III restriction enzyme, res subunit Sin_N PF04801.13 ETO19131.1 - 0.62 9.2 10.9 0.99 8.5 10.9 1.5 1 1 0 1 1 1 0 Sin-like protein conserved region CDC45 PF02724.14 ETO19131.1 - 0.82 7.9 9.2 0.92 7.7 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Striatin PF08232.12 ETO19131.1 - 1.3 9.6 15.0 2.1 8.9 14.8 1.4 1 1 0 1 1 1 0 Striatin family Dicty_REP PF05086.12 ETO19131.1 - 1.6 6.6 11.8 1.8 6.5 11.8 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PIEZO PF15917.5 ETO19131.1 - 1.7 8.1 10.7 2.2 7.7 10.7 1.1 1 0 0 1 1 1 0 Piezo Neur_chan_memb PF02932.16 ETO19131.1 - 2.8 7.9 5.3 3.3 7.7 5.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CNDH2_N PF06278.11 ETO19131.1 - 2.9 8.1 7.8 0.45 10.7 2.9 1.9 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, N-terminal PRIMA1 PF16101.5 ETO19132.1 - 0.29 11.2 9.1 1.8 8.6 1.1 2.6 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 CAF1-p150_C2 PF15539.6 ETO19133.1 - 0.0054 16.2 1.9 0.0065 16.0 1.9 1.1 1 0 0 1 1 1 1 CAF1 complex subunit p150, region binding to CAF1-p60 at C-term Pacs-1 PF10254.9 ETO19133.1 - 0.0083 15.1 9.8 0.0092 15.0 9.8 1.0 1 0 0 1 1 1 1 PACS-1 cytosolic sorting protein FancD2 PF14631.6 ETO19133.1 - 0.11 9.8 10.1 0.12 9.7 10.1 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Vfa1 PF08432.10 ETO19133.1 - 0.22 11.9 16.5 0.27 11.5 16.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DDHD PF02862.17 ETO19133.1 - 0.25 11.5 7.5 0.3 11.2 7.5 1.1 1 0 0 1 1 1 0 DDHD domain Myc_N PF01056.18 ETO19133.1 - 0.56 10.1 11.1 0.67 9.8 11.1 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Proton_antipo_C PF01010.19 ETO19133.1 - 0.56 9.8 4.1 0.69 9.5 4.1 1.2 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Sec62 PF03839.16 ETO19133.1 - 0.82 9.1 17.2 1 8.8 17.2 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 p450 PF00067.22 ETO19133.1 - 0.83 8.3 7.1 0.94 8.1 6.3 1.3 1 1 0 1 1 1 0 Cytochrome P450 EOS1 PF12326.8 ETO19133.1 - 1.1 9.2 3.7 1.3 9.0 3.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein TP53IP5 PF15331.6 ETO19133.1 - 2.1 8.4 16.4 2.6 8.1 16.4 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Presenilin PF01080.17 ETO19133.1 - 6.5 5.4 10.0 7.2 5.3 10.0 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO19133.1 - 7.1 6.6 6.6 8 6.4 6.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DNA_pol_phi PF04931.13 ETO19134.1 - 0.072 11.2 31.5 0.082 11.0 31.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO19134.1 - 0.17 10.1 20.9 0.17 10.1 20.9 1.0 1 0 0 1 1 1 0 Nop14-like family SpoIIIAH PF12685.7 ETO19134.1 - 0.38 10.5 6.1 0.4 10.5 6.1 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein IFT57 PF10498.9 ETO19134.1 - 0.56 9.1 9.2 0.56 9.1 9.2 1.0 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 CNDH2_C PF16858.5 ETO19134.1 - 0.78 9.6 8.9 0.73 9.7 8.9 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term FYDLN_acid PF09538.10 ETO19134.1 - 0.99 10.1 28.4 1.6 9.4 28.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Cwf_Cwc_15 PF04889.12 ETO19134.1 - 1.7 8.3 31.3 2.6 7.7 31.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SDA1 PF05285.12 ETO19134.1 - 1.9 7.8 22.4 2 7.8 22.4 1.0 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 ETO19134.1 - 2.3 6.9 4.1 2.4 6.9 4.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RRN3 PF05327.11 ETO19134.1 - 2.4 6.6 18.6 2.4 6.6 18.6 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 ETO19134.1 - 2.6 7.2 11.8 2.7 7.1 11.8 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 ETO19134.1 - 3.6 5.8 17.5 3.9 5.7 17.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Cnd2 PF05786.14 ETO19134.1 - 5.1 5.6 17.6 5.3 5.6 17.6 1.0 1 0 0 1 1 1 0 Condensin complex subunit 2 DUF2722 PF10846.8 ETO19134.1 - 5.6 5.8 14.7 6.4 5.6 14.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SAPS PF04499.15 ETO19134.1 - 8.3 5.1 8.0 8.5 5.0 8.0 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Nop14 PF04147.12 ETO19135.1 - 3.4 5.8 24.6 4.4 5.4 24.6 1.2 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 ETO19137.1 - 9.6 4.6 6.5 13 4.2 6.5 1.1 1 0 0 1 1 1 0 Macoilin family C2 PF00168.30 ETO19138.1 - 1.6e-20 73.3 1.1 2.6e-20 72.6 0.6 1.6 2 0 0 2 2 2 1 C2 domain Ras PF00071.22 ETO19139.1 - 0.00022 20.9 1.2 0.0004 20.0 0.1 1.8 2 0 0 2 2 2 1 Ras family Tom7 PF08038.12 ETO19139.1 - 0.035 13.8 0.0 0.098 12.3 0.0 1.7 1 0 0 1 1 1 0 TOM7 family DUF3099 PF11298.8 ETO19139.1 - 0.038 14.1 0.2 0.18 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) MAAL_C PF07476.11 ETO19139.1 - 0.065 12.4 0.1 0.089 11.9 0.1 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus PTPRCAP PF15713.5 ETO19141.1 - 0.00096 19.5 11.2 0.0013 19.1 11.2 1.2 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated DUF2992 PF11208.8 ETO19141.1 - 0.0034 17.6 4.0 0.004 17.4 4.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2992) DUF2052 PF09747.9 ETO19141.1 - 0.0056 16.8 10.7 0.0059 16.8 10.7 1.1 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Merozoite_SPAM PF07133.11 ETO19141.1 - 0.013 15.5 19.5 0.016 15.2 19.5 1.1 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) RR_TM4-6 PF06459.12 ETO19141.1 - 0.013 15.3 8.3 0.014 15.2 8.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Molybdopterin PF00384.22 ETO19141.1 - 0.018 14.0 0.1 0.019 14.0 0.1 1.0 1 0 0 1 1 1 0 Molybdopterin oxidoreductase CPSF100_C PF13299.6 ETO19141.1 - 0.031 14.5 5.0 0.04 14.1 5.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 ETO19141.1 - 0.063 12.9 10.4 0.082 12.6 10.4 1.2 1 0 0 1 1 1 0 FAM176 family RNA_pol_Rpc4 PF05132.14 ETO19141.1 - 0.069 13.6 5.6 0.082 13.3 5.6 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Hid1 PF12722.7 ETO19141.1 - 0.089 10.9 4.7 0.089 10.9 4.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 ETO19141.1 - 0.12 10.6 10.6 0.14 10.5 10.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO19141.1 - 0.24 11.1 5.1 0.3 10.8 5.1 1.2 1 0 0 1 1 1 0 Connexin Paf1 PF03985.13 ETO19141.1 - 0.53 9.2 17.4 0.64 9.0 17.4 1.1 1 0 0 1 1 1 0 Paf1 DUF4746 PF15928.5 ETO19141.1 - 0.53 9.7 11.8 0.64 9.4 11.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF4637 PF15470.6 ETO19141.1 - 0.68 9.7 17.6 0.96 9.2 17.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) MDM10 PF12519.8 ETO19141.1 - 1.1 8.0 9.8 1.5 7.6 9.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Afi1 PF07792.12 ETO19141.1 - 1.2 9.6 10.3 1.6 9.2 10.3 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 ETO19141.1 - 1.4 7.6 11.1 1.8 7.3 11.1 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO19141.1 - 1.5 7.5 6.5 1.7 7.4 6.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter NPR3 PF03666.13 ETO19141.1 - 2 7.1 10.9 2.5 6.8 10.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CobT PF06213.12 ETO19141.1 - 3.4 7.0 16.5 4.3 6.6 16.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM163 PF15069.6 ETO19141.1 - 3.4 8.1 7.6 4.8 7.6 7.6 1.2 1 0 0 1 1 1 0 FAM163 family CLN3 PF02487.17 ETO19141.1 - 4.3 6.3 5.3 5.2 6.0 5.3 1.1 1 0 0 1 1 1 0 CLN3 protein DUF4820 PF16091.5 ETO19141.1 - 4.6 6.5 10.1 5.9 6.2 10.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) MCM_bind PF09739.9 ETO19141.1 - 6.8 5.0 12.1 8.6 4.7 12.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor ATP-synt_E PF05680.12 ETO19141.1 - 9.7 6.6 11.4 19 5.7 11.4 1.5 1 0 0 1 1 1 0 ATP synthase E chain GH115_C PF17829.1 ETO19142.1 - 0.052 13.4 0.2 0.054 13.3 0.2 1.0 1 0 0 1 1 1 0 Gylcosyl hydrolase family 115 C-terminal domain Kelch_5 PF13854.6 ETO19144.1 - 3.3e-05 23.8 0.2 30 4.7 0.0 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO19144.1 - 0.00016 21.9 1.6 0.22 11.9 0.1 3.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO19144.1 - 0.0099 15.9 0.2 0.18 11.8 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain MORN PF02493.20 ETO19146.1 - 2.1e-23 80.8 42.3 6.6e-08 32.0 0.2 7.9 8 0 0 8 8 8 7 MORN repeat DUF1419 PF07215.11 ETO19146.1 - 3.3 7.8 6.2 3.7 7.7 0.0 3.9 2 1 3 6 6 6 0 Protein of unknown function (DUF1419) Calici_coat_C PF08435.11 ETO19146.1 - 8.3 5.9 7.1 0.45 10.0 1.2 1.8 2 0 0 2 2 2 0 Calicivirus coat protein C-terminal Alpha_kinase PF02816.18 ETO19147.1 - 3.7e-46 157.6 0.1 5.1e-46 157.1 0.1 1.2 1 0 0 1 1 1 1 Alpha-kinase family Med26 PF08711.11 ETO19147.1 - 0.028 14.4 0.0 0.58 10.2 0.0 2.5 2 0 0 2 2 2 0 TFIIS helical bundle-like domain Pkinase PF00069.25 ETO19148.1 - 0.0097 15.3 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Ion_trans PF00520.31 ETO19151.1 - 1.1e-24 87.0 0.0 2.2e-23 82.8 0.1 2.0 2 0 0 2 2 2 1 Ion transport protein USP19_linker PF16602.5 ETO19151.1 - 0.058 14.0 0.4 0.11 13.1 0.4 1.4 1 0 0 1 1 1 0 Linker region of USP19 deubiquitinase Cadherin_C_2 PF16492.5 ETO19151.1 - 0.25 12.1 0.1 0.25 12.1 0.1 2.0 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal PKD_channel PF08016.12 ETO19151.1 - 0.72 8.5 4.3 6.2 5.4 1.6 2.2 1 1 1 2 2 2 0 Polycystin cation channel Presenilin PF01080.17 ETO19151.1 - 1.1 8.0 4.7 0.34 9.6 0.9 1.8 2 0 0 2 2 2 0 Presenilin DUF5305 PF17231.2 ETO19152.1 - 0.00041 19.8 0.3 0.00079 18.9 0.3 1.5 1 1 0 1 1 1 1 Family of unknown function (DUF5305) DUF3377 PF11857.8 ETO19152.1 - 0.0074 16.2 0.6 0.016 15.1 0.3 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF3377) OAD_gamma PF04277.13 ETO19152.1 - 0.0078 16.8 10.2 0.1 13.2 0.1 2.2 1 1 1 2 2 2 1 Oxaloacetate decarboxylase, gamma chain EphA2_TM PF14575.6 ETO19152.1 - 0.011 16.6 0.2 1.6 9.7 0.0 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain ETRAMP PF09716.10 ETO19152.1 - 0.021 14.8 3.1 0.16 12.0 2.6 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) SIT PF15330.6 ETO19152.1 - 0.023 15.1 0.1 4.1 7.9 0.0 2.3 2 0 0 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT ECF_trnsprt PF12822.7 ETO19152.1 - 0.027 14.6 0.0 0.038 14.1 0.0 1.2 1 0 0 1 1 1 0 ECF transporter, substrate-specific component Peptidase_M56 PF05569.11 ETO19152.1 - 0.097 11.9 0.0 0.12 11.5 0.0 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 FAM176 PF14851.6 ETO19152.1 - 0.12 12.0 0.0 0.12 12.0 0.0 2.2 1 1 1 2 2 2 0 FAM176 family Peptidase_S49_N PF08496.10 ETO19152.1 - 0.15 12.1 9.1 1.1 9.3 7.3 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4834 PF16118.5 ETO19152.1 - 0.35 11.9 5.9 13 6.9 0.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) Connexin PF00029.19 ETO19152.1 - 0.38 10.5 2.5 0.47 10.2 1.7 1.6 1 1 1 2 2 2 0 Connexin RIC3 PF15361.6 ETO19152.1 - 0.52 10.7 0.0 0.52 10.7 0.0 2.1 1 1 1 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 SR-25 PF10500.9 ETO19152.1 - 0.63 9.6 14.2 1.1 8.8 14.2 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein OATP PF03137.20 ETO19152.1 - 1.1 7.5 2.2 32 2.6 0.0 2.0 1 1 1 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF2207 PF09972.9 ETO19152.1 - 1.2 7.9 5.4 2 7.1 5.4 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MFS_Mycoplasma PF07672.13 ETO19152.1 - 1.3 8.2 4.4 3.3 6.9 0.0 2.1 2 0 0 2 2 2 0 Mycoplasma MFS transporter O-ag_pol_Wzy PF14296.6 ETO19152.1 - 1.3 7.6 3.8 18 3.8 2.6 2.0 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy DUF2371 PF10177.9 ETO19152.1 - 1.8 8.7 0.0 1.8 8.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2371) Vpu PF00558.19 ETO19152.1 - 2.5 7.9 0.0 2.5 7.9 0.0 2.6 2 1 0 2 2 1 0 Vpu protein DUF3899 PF13038.6 ETO19152.1 - 4.6 7.8 8.3 5.1 7.7 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) AAA_11 PF13086.6 ETO19153.1 - 0.23 11.2 7.4 0.29 10.9 7.4 1.1 1 0 0 1 1 1 0 AAA domain Ubiquitin_3 PF14836.6 ETO19153.1 - 0.27 11.3 0.2 0.27 11.3 0.2 2.3 1 1 1 2 2 2 0 Ubiquitin-like domain HEAT PF02985.22 ETO19154.1 - 9.8e-16 56.5 1.5 0.001 19.1 0.1 8.6 8 0 0 8 8 8 3 HEAT repeat HEAT_EZ PF13513.6 ETO19154.1 - 7.1e-13 48.8 1.1 0.033 14.7 0.0 8.1 8 0 0 8 8 8 2 HEAT-like repeat SF3b1 PF08920.10 ETO19154.1 - 2.9e-11 43.9 0.2 7.1e-11 42.7 0.2 1.7 1 1 0 1 1 1 1 Splicing factor 3B subunit 1 HEAT_2 PF13646.6 ETO19154.1 - 7.6e-10 39.0 5.8 0.023 15.1 0.1 6.6 3 2 5 8 8 8 2 HEAT repeats DUF3385 PF11865.8 ETO19154.1 - 1.4e-06 28.3 4.5 0.38 10.7 0.0 5.7 3 2 3 6 6 6 1 Domain of unknown function (DUF3385) Cnd1 PF12717.7 ETO19154.1 - 1.5e-05 25.1 8.4 0.21 11.6 0.0 6.8 7 2 0 7 7 7 1 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETO19154.1 - 2.5e-05 23.9 0.1 0.22 11.0 0.0 4.6 4 1 1 5 5 5 1 CLASP N terminal NUC173 PF08161.12 ETO19154.1 - 0.00025 20.8 0.4 0.28 10.8 0.0 4.6 6 1 0 6 6 6 1 NUC173 domain MMS19_C PF12460.8 ETO19154.1 - 0.00093 18.4 0.0 0.078 12.1 0.0 3.4 3 1 1 4 4 4 1 RNAPII transcription regulator C-terminal Dopey_N PF04118.14 ETO19154.1 - 0.004 16.3 0.1 57 2.7 0.1 4.2 2 1 1 4 4 4 0 Dopey, N-terminal Vac14_Fab1_bd PF12755.7 ETO19154.1 - 0.0046 17.5 2.2 85 3.8 0.0 6.4 7 0 0 7 7 7 0 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ETO19154.1 - 0.0054 15.3 2.5 0.72 8.3 0.0 3.6 3 2 0 4 4 4 1 Adaptin N terminal region UNC45-central PF11701.8 ETO19154.1 - 0.012 15.6 0.9 0.069 13.1 0.0 2.6 3 0 0 3 3 3 0 Myosin-binding striated muscle assembly central MMS19_N PF14500.6 ETO19154.1 - 0.043 13.4 0.2 3.2 7.3 0.0 3.8 5 1 0 5 5 5 0 Dos2-interacting transcription regulator of RNA-Pol-II Arm PF00514.23 ETO19154.1 - 0.043 13.9 0.1 69 3.7 0.0 5.3 5 1 1 6 6 6 0 Armadillo/beta-catenin-like repeat UPF0149 PF03695.13 ETO19155.1 - 0.14 12.4 0.2 0.14 12.4 0.2 1.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0149) Myb_DNA-bind_6 PF13921.6 ETO19156.1 - 0.042 14.1 2.6 0.38 11.1 0.2 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain ACT_7 PF13840.6 ETO19159.1 - 0.068 13.0 0.1 0.13 12.1 0.1 1.4 1 0 0 1 1 1 0 ACT domain Pentapeptide_4 PF13599.6 ETO19159.1 - 0.087 13.0 0.3 0.2 11.9 0.1 1.7 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) Pkinase PF00069.25 ETO19161.1 - 9.7e-58 195.6 0.1 9.7e-58 195.6 0.1 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19161.1 - 2.1e-31 109.1 0.1 2.1e-31 109.1 0.1 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO19161.1 - 3.5e-06 26.5 0.0 8.5e-06 25.3 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Vma12 PF11712.8 ETO19161.1 - 0.46 10.5 2.8 1.4 9.0 2.8 1.8 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Cytomega_UL84 PF06284.11 ETO19162.1 - 1.6 7.1 5.8 2.4 6.5 5.8 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RR_TM4-6 PF06459.12 ETO19162.1 - 5.2 6.8 18.0 0.34 10.7 2.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 BAR_3 PF16746.5 ETO19164.1 - 0.0014 18.4 1.5 0.0014 18.4 1.5 1.8 2 1 0 2 2 2 1 BAR domain of APPL family TSNAXIP1_N PF15739.5 ETO19164.1 - 0.29 11.5 7.6 0.11 12.9 4.3 2.0 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus MCPsignal PF00015.21 ETO19165.1 - 0.004 17.0 20.6 0.18 11.6 4.4 2.5 1 1 1 2 2 2 2 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF1241 PF06840.11 ETO19165.1 - 0.02 14.5 2.5 1.9 8.2 0.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1241) FlgN PF05130.12 ETO19165.1 - 0.13 12.8 0.1 0.69 10.4 0.1 2.1 2 1 1 3 3 3 0 FlgN protein Ferritin PF00210.24 ETO19165.1 - 0.23 11.4 1.2 0.83 9.6 0.2 2.2 2 0 0 2 2 2 0 Ferritin-like domain DASH_Duo1 PF08651.10 ETO19165.1 - 1.8 8.4 4.6 6.5 6.6 0.6 2.7 2 0 0 2 2 2 0 DASH complex subunit Duo1 ECH_1 PF00378.20 ETO19166.1 - 1.8e-34 119.2 0.0 1.9e-20 73.2 0.0 2.1 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO19166.1 - 1.3e-18 67.7 0.0 3.3e-18 66.3 0.0 1.6 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase SUR7 PF06687.12 ETO19168.1 - 0.0082 15.8 0.9 0.0082 15.8 0.9 2.8 3 0 0 3 3 3 1 SUR7/PalI family DUF3671 PF12420.8 ETO19168.1 - 0.01 15.9 1.0 0.049 13.7 1.0 2.2 1 0 0 1 1 1 0 Protein of unknown function DUF4834 PF16118.5 ETO19168.1 - 0.023 15.7 2.8 0.023 15.7 2.8 5.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4834) TMEM107 PF14995.6 ETO19168.1 - 0.032 14.7 1.3 0.096 13.1 1.3 1.7 1 0 0 1 1 1 0 Transmembrane protein OAD_gamma PF04277.13 ETO19168.1 - 0.066 13.8 0.7 0.24 12.0 0.7 2.0 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain 7TM_GPCR_Srw PF10324.9 ETO19168.1 - 0.2 10.9 8.5 0.15 11.3 6.2 1.9 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw Comm PF15957.5 ETO19168.1 - 6 7.2 10.3 0.21 12.0 2.4 2.6 2 1 0 2 2 2 0 Commissureless TPR_2 PF07719.17 ETO19169.1 - 0.0044 17.0 0.3 0.014 15.4 0.3 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO19169.1 - 0.015 15.1 1.2 0.036 13.9 1.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO19169.1 - 0.071 13.8 0.3 0.071 13.8 0.3 1.8 2 0 0 2 2 2 0 Sel1 repeat DUF3924 PF13062.6 ETO19170.1 - 0.013 15.5 0.1 0.04 13.9 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3924) BOFC_N PF08977.10 ETO19172.1 - 0.062 13.3 1.1 0.12 12.4 1.1 1.5 1 0 0 1 1 1 0 Bypass of Forespore C, N terminal PRK PF00485.18 ETO19174.1 - 2.1e-33 115.8 2.7 2.5e-29 102.4 0.4 2.9 1 1 1 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ETO19174.1 - 0.00012 22.7 0.3 0.00032 21.2 0.0 1.9 2 0 0 2 2 2 1 AAA domain Cytidylate_kin PF02224.18 ETO19174.1 - 0.00055 19.7 0.4 0.056 13.2 0.0 2.2 1 1 1 2 2 2 2 Cytidylate kinase CoaE PF01121.20 ETO19174.1 - 0.0052 16.5 0.5 0.15 11.7 0.0 2.3 2 0 0 2 2 2 1 Dephospho-CoA kinase CPT PF07931.12 ETO19174.1 - 0.062 13.1 0.0 0.095 12.5 0.0 1.4 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein Zeta_toxin PF06414.12 ETO19174.1 - 0.11 11.8 0.5 0.65 9.2 0.0 2.4 3 1 0 3 3 3 0 Zeta toxin DUF4614 PF15391.6 ETO19175.1 - 0.0034 17.4 16.5 0.0034 17.4 16.5 3.2 2 1 1 3 3 3 1 Domain of unknown function (DUF4614) SOG2 PF10428.9 ETO19175.1 - 0.13 11.4 39.5 0.17 11.0 39.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Neur_chan_memb PF02932.16 ETO19176.1 - 0.12 12.5 6.6 0.17 11.9 6.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO19176.1 - 0.17 10.6 3.0 0.2 10.4 3.0 1.2 1 0 0 1 1 1 0 Presenilin MDM10 PF12519.8 ETO19176.1 - 3.4 6.4 9.0 4 6.2 9.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Pkinase PF00069.25 ETO19177.1 - 7.2e-54 182.9 0.0 9.6e-54 182.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19177.1 - 1.8e-22 79.9 0.0 2.7e-22 79.3 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO19177.1 - 2.8e-05 23.6 0.0 4.8e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO19177.1 - 0.0025 17.2 0.0 0.0041 16.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO19177.1 - 0.0031 17.5 0.0 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ETO19177.1 - 0.018 14.0 0.3 0.24 10.3 0.0 2.3 2 1 0 2 2 2 0 Poxvirus serine/threonine protein kinase rRNA_processing PF08524.11 ETO19178.1 - 5.1e-09 36.3 18.2 5.1e-09 36.3 18.2 4.0 1 1 3 4 4 4 1 rRNA processing Pkinase PF00069.25 ETO19179.1 - 2.1e-19 69.9 2.1 2.9e-11 43.3 0.0 3.3 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19179.1 - 1.4e-08 34.3 0.2 0.00081 18.7 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Phage_Gp23 PF10669.9 ETO19179.1 - 3.5 8.0 6.8 3.1 8.2 0.2 3.3 4 0 0 4 4 4 0 Protein gp23 (Bacteriophage A118) HSP70 PF00012.20 ETO19180.1 - 3e-160 534.3 0.5 1.2e-159 532.3 0.5 1.7 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO19180.1 - 7.1e-06 25.1 0.1 4.8e-05 22.3 0.1 2.2 2 0 0 2 2 2 1 MreB/Mbl protein FGGY_C PF02782.16 ETO19180.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Ras PF00071.22 ETO19181.1 - 5.5e-48 162.6 0.2 9.5e-48 161.9 0.2 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO19181.1 - 1e-18 67.6 0.0 3e-18 66.2 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO19181.1 - 3.7e-11 42.8 0.0 5.7e-11 42.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO19181.1 - 4e-05 23.6 0.0 0.014 15.3 0.0 2.4 2 0 0 2 2 2 2 RsgA GTPase ATP_bind_1 PF03029.17 ETO19181.1 - 0.00067 19.5 0.6 0.0054 16.5 0.0 2.2 1 1 1 2 2 2 1 Conserved hypothetical ATP binding protein TSLP PF15216.6 ETO19181.1 - 0.023 15.0 0.8 0.051 13.8 0.8 1.5 1 0 0 1 1 1 0 Thymic stromal lymphopoietin SRPRB PF09439.10 ETO19181.1 - 0.025 14.0 0.0 0.053 13.0 0.0 1.5 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit GTP_EFTU PF00009.27 ETO19181.1 - 0.037 13.6 0.1 0.18 11.3 0.1 2.0 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO19181.1 - 0.046 13.8 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF2238 PF09997.9 ETO19181.1 - 0.12 12.2 2.0 0.43 10.4 0.4 2.4 1 1 1 2 2 2 0 Predicted membrane protein (DUF2238) DUF2075 PF09848.9 ETO19181.1 - 3.6 6.7 5.8 6.4 5.9 0.0 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2075) SHE3 PF17078.5 ETO19182.1 - 0.0026 17.5 30.6 0.0026 17.5 30.6 3.0 1 1 1 2 2 2 1 SWI5-dependent HO expression protein 3 Ca_bind_SSO6904 PF18249.1 ETO19182.1 - 1.4 9.3 12.1 0.21 11.9 0.4 3.9 3 2 0 3 3 3 0 Calcium binding protein SSO6904 CTP_transf_like PF01467.26 ETO19182.1 - 2.9 8.1 6.4 1.1 9.4 0.4 2.5 2 1 0 2 2 2 0 Cytidylyltransferase-like PhoD_N PF16655.5 ETO19183.1 - 0.24 12.0 1.1 0.7 10.5 1.1 1.8 1 1 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain DUF3575 PF12099.8 ETO19183.1 - 3.8 6.8 5.6 6.5 6.0 5.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3575) DUF4199 PF13858.6 ETO19185.1 - 0.0052 17.2 0.9 0.013 15.9 0.9 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF4199) SARAF PF06682.12 ETO19185.1 - 0.062 12.9 5.7 0.56 9.8 5.7 2.0 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Nucleoside_tran PF01733.18 ETO19185.1 - 0.098 12.0 0.2 0.098 12.0 0.2 1.9 1 1 1 2 2 2 0 Nucleoside transporter Fez1 PF06818.15 ETO19185.1 - 0.17 12.4 40.1 0.92 9.9 40.1 2.0 1 1 0 1 1 1 0 Fez1 FliD_N PF02465.18 ETO19185.1 - 0.24 12.1 12.5 0.87 10.3 0.8 2.8 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus HCO3_cotransp PF00955.21 ETO19185.1 - 0.27 10.0 2.4 0.22 10.3 1.1 1.4 1 1 0 1 1 1 0 HCO3- transporter family SID-1_RNA_chan PF13965.6 ETO19185.1 - 0.3 9.5 8.4 0.42 9.0 8.4 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAD_M PF08527.10 ETO19185.1 - 0.31 10.7 4.7 0.82 9.3 4.7 1.7 1 0 0 1 1 1 0 Protein-arginine deiminase (PAD) middle domain DUF1024 PF06260.12 ETO19185.1 - 0.42 10.9 4.1 0.4 11.0 1.0 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF1024) Sec34 PF04136.15 ETO19185.1 - 0.71 9.7 18.9 1.1 9.1 5.4 2.7 2 1 2 4 4 4 0 Sec34-like family CSG2 PF16965.5 ETO19185.1 - 0.8 8.6 4.0 0.44 9.4 1.9 1.5 1 1 0 1 1 1 0 Ceramide synthase regulator DUF2208 PF09973.9 ETO19185.1 - 1.9 8.0 5.7 0.98 9.0 3.4 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2208) MCU PF04678.13 ETO19185.1 - 3 7.9 13.9 0.093 12.8 1.2 2.4 2 0 0 2 2 2 0 Mitochondrial calcium uniporter MSL1_dimer PF16801.5 ETO19185.1 - 6.8 6.6 13.7 17 5.3 0.4 3.1 2 0 0 2 2 2 0 Dimerisation domain of Male-specific-Lethal 1 TMPIT PF07851.13 ETO19185.1 - 10 5.3 20.5 0.49 9.6 2.3 2.4 2 0 0 2 2 2 0 TMPIT-like protein DUF4064 PF13273.6 ETO19186.1 - 0.0021 18.3 0.2 0.007 16.6 0.2 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4064) TMEM51 PF15345.6 ETO19186.1 - 0.0023 17.8 0.1 0.0077 16.1 0.1 1.9 1 0 0 1 1 1 1 Transmembrane protein 51 Arv1 PF04161.13 ETO19186.1 - 0.018 15.2 1.5 0.097 12.8 0.3 2.1 2 0 0 2 2 2 0 Arv1-like family DUF3671 PF12420.8 ETO19186.1 - 0.038 14.1 1.2 0.098 12.7 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function MFS_1 PF07690.16 ETO19186.1 - 0.055 12.4 0.3 0.087 11.7 0.3 1.2 1 0 0 1 1 1 0 Major Facilitator Superfamily Shisa PF13908.6 ETO19186.1 - 0.12 12.6 0.8 0.42 10.8 0.2 2.2 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator WBP-1 PF11669.8 ETO19186.1 - 0.81 10.3 3.3 6.3 7.5 3.4 2.5 1 1 1 2 2 2 0 WW domain-binding protein 1 Tristanin_u2 PF16638.5 ETO19186.1 - 7.3 7.4 7.0 2.5 9.0 2.8 2.3 3 0 0 3 3 3 0 Unstructured region on methyltransferase between zinc-fingers DUF5316 PF17247.2 ETO19188.1 - 0.22 11.6 0.5 11 6.1 0.0 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5316) WD40 PF00400.32 ETO19189.1 - 4.4e-37 125.4 15.6 7.2e-10 39.3 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19189.1 - 5.8e-16 58.6 4.6 0.0051 17.1 0.0 5.7 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19189.1 - 4.8e-11 42.2 1.0 0.0046 16.0 0.1 4.3 1 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO19189.1 - 4.5e-06 25.6 7.5 0.071 11.7 0.0 4.5 2 2 1 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO19189.1 - 2.2e-05 23.2 0.7 0.0051 15.4 0.0 2.3 1 1 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO19189.1 - 3e-05 23.8 1.4 0.53 10.3 0.1 5.5 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Mid2 PF04478.12 ETO19189.1 - 0.0019 18.1 0.2 0.092 12.6 0.0 2.9 2 1 1 3 3 3 1 Mid2 like cell wall stress sensor WD40_like PF17005.5 ETO19189.1 - 0.0021 17.4 0.1 0.46 9.8 0.1 2.9 1 1 1 3 3 3 2 WD40-like domain Str_synth PF03088.16 ETO19189.1 - 0.0026 17.8 0.0 0.061 13.4 0.0 3.1 4 0 0 4 4 4 1 Strictosidine synthase Nbas_N PF15492.6 ETO19189.1 - 0.0027 17.1 1.1 0.57 9.5 0.0 3.8 2 2 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO19189.1 - 0.017 15.2 0.3 0.49 10.5 0.0 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5570) SoxZ PF08770.11 ETO19189.1 - 0.083 12.7 0.0 15 5.4 0.0 3.3 3 0 0 3 3 3 0 Sulphur oxidation protein SoxZ Kinesin PF00225.23 ETO19190.1 - 4.3e-114 380.9 1.1 4.3e-114 380.9 1.1 2.7 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO19190.1 - 8.6e-25 87.4 0.1 8.6e-25 87.4 0.1 3.2 2 1 1 3 3 3 1 Microtubule binding Cellulose_synt PF03552.14 ETO19190.1 - 2.7 6.4 11.0 4 5.8 11.0 1.1 1 0 0 1 1 1 0 Cellulose synthase DUF4834 PF16118.5 ETO19191.1 - 0.0084 17.1 0.7 0.02 15.8 0.7 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) MAP17 PF15807.5 ETO19191.1 - 0.031 14.5 0.9 0.052 13.8 0.9 1.3 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Secretin_N_2 PF07655.13 ETO19191.1 - 0.04 14.5 11.1 0.08 13.5 11.1 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4605 PF15378.6 ETO19191.1 - 0.091 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4605) Presenilin PF01080.17 ETO19191.1 - 0.2 10.4 0.3 0.34 9.6 0.3 1.3 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 ETO19192.1 - 2.1e-24 86.3 2.4 2.1e-11 43.7 0.0 3.3 2 2 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19192.1 - 3.8e-09 36.2 0.0 4.5e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO19192.1 - 1.6e-07 30.4 0.1 3.4e-07 29.4 0.1 1.6 1 1 0 1 1 1 1 Fungal protein kinase Raftlin PF15250.6 ETO19192.1 - 0.0053 15.6 3.9 0.0055 15.5 3.9 1.1 1 0 0 1 1 1 1 Raftlin Nop14 PF04147.12 ETO19192.1 - 0.012 13.9 17.9 0.014 13.7 17.9 1.1 1 0 0 1 1 1 0 Nop14-like family DUF913 PF06025.12 ETO19192.1 - 0.014 14.4 6.2 0.017 14.1 6.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) BUD22 PF09073.10 ETO19192.1 - 0.032 13.6 16.9 0.039 13.3 16.9 1.1 1 0 0 1 1 1 0 BUD22 DDHD PF02862.17 ETO19192.1 - 0.033 14.3 1.0 0.035 14.3 1.0 1.2 1 0 0 1 1 1 0 DDHD domain Vfa1 PF08432.10 ETO19192.1 - 0.038 14.3 14.2 0.056 13.8 14.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3827 PF12877.7 ETO19192.1 - 0.053 11.9 4.7 0.064 11.6 4.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Astro_capsid_p PF12226.8 ETO19192.1 - 0.12 11.5 13.7 0.15 11.2 13.7 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Pox_Ag35 PF03286.14 ETO19192.1 - 0.17 11.7 15.3 0.23 11.2 15.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CobT PF06213.12 ETO19192.1 - 0.19 11.1 18.8 0.26 10.6 18.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RAB3GAP2_C PF14656.6 ETO19192.1 - 0.28 9.4 7.5 0.4 8.9 7.5 1.2 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus CNDH2_C PF16858.5 ETO19192.1 - 0.3 10.9 14.1 0.37 10.6 14.1 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Zip PF02535.22 ETO19192.1 - 0.3 10.2 6.7 0.33 10.1 6.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO19192.1 - 0.34 9.7 9.5 0.46 9.2 9.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SDA1 PF05285.12 ETO19192.1 - 0.34 10.3 22.1 0.42 10.0 22.1 1.1 1 0 0 1 1 1 0 SDA1 Smg8_Smg9 PF10220.9 ETO19192.1 - 0.53 8.5 6.6 0.76 8.0 6.6 1.3 1 0 0 1 1 1 0 Smg8_Smg9 SLC12 PF03522.15 ETO19192.1 - 0.91 8.5 6.5 1.1 8.2 6.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO19192.1 - 1.1 7.5 18.0 1.4 7.1 18.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 ETO19192.1 - 1.2 7.6 13.4 1.6 7.3 13.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator RNA_pol_3_Rpc31 PF11705.8 ETO19192.1 - 1.4 9.1 26.5 1.9 8.7 26.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 RP-C_C PF11800.8 ETO19192.1 - 1.4 9.0 8.0 1.8 8.6 8.0 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Tim54 PF11711.8 ETO19192.1 - 1.4 7.6 11.5 1.7 7.4 11.5 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HNF-1_N PF04814.13 ETO19192.1 - 2.2 8.8 8.9 3.1 8.4 8.9 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF4820 PF16091.5 ETO19192.1 - 2.9 7.2 10.5 4.2 6.7 10.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) IPK PF03770.16 ETO19192.1 - 3 7.6 10.3 11 5.9 10.2 2.0 1 1 0 1 1 1 0 Inositol polyphosphate kinase Serinc PF03348.15 ETO19192.1 - 3.7 6.4 4.2 4.2 6.2 4.2 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) RNA_pol_Rpc4 PF05132.14 ETO19192.1 - 3.8 7.9 9.9 5.5 7.4 9.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETO19192.1 - 3.9 6.1 13.4 6.3 5.4 13.4 1.3 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETO19192.1 - 4 5.4 8.5 4.8 5.2 8.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PPP4R2 PF09184.11 ETO19192.1 - 4.1 6.9 22.1 5.6 6.5 22.1 1.2 1 0 0 1 1 1 0 PPP4R2 PA26 PF04636.13 ETO19192.1 - 4.3 6.2 10.1 5.6 5.8 10.1 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Trypan_PARP PF05887.11 ETO19192.1 - 4.4 7.3 18.8 6.4 6.8 18.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4746 PF15928.5 ETO19192.1 - 4.4 6.6 20.1 5.8 6.2 20.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPL5 PF18168.1 ETO19192.1 - 5.1 6.3 9.6 6.7 5.9 9.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF740 PF05340.12 ETO19192.1 - 5.9 5.5 11.8 6.7 5.3 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Afi1 PF07792.12 ETO19192.1 - 6.3 7.3 13.4 9.4 6.7 13.4 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking ALMT PF11744.8 ETO19192.1 - 6.4 5.5 7.8 8.4 5.1 7.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter TRAP_alpha PF03896.16 ETO19192.1 - 7.9 5.6 14.1 12 5.0 14.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PTPRCAP PF15713.5 ETO19192.1 - 7.9 6.8 23.2 12 6.2 23.2 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CLN3 PF02487.17 ETO19192.1 - 8.6 5.3 5.3 11 4.9 5.3 1.1 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 ETO19192.1 - 9.5 5.9 8.5 14 5.4 8.5 1.3 1 0 0 1 1 1 0 Connexin Membralin PF09746.9 ETO19192.1 - 9.8 5.1 6.7 12 4.8 6.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein PTPLA PF04387.14 ETO19193.1 - 1.9e-26 92.7 10.4 2.3e-26 92.5 10.4 1.0 1 0 0 1 1 1 1 Protein tyrosine phosphatase-like protein, PTPLA Patatin PF01734.22 ETO19195.1 - 0.036 14.2 0.3 0.04 14.1 0.3 1.1 1 0 0 1 1 1 0 Patatin-like phospholipase Aldedh PF00171.22 ETO19196.1 - 1.3e-28 99.8 0.0 1.5e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Trypan_PARP PF05887.11 ETO19197.1 - 4.5e-07 29.9 18.5 8.8e-07 29.0 18.5 1.5 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) PGA2 PF07543.12 ETO19197.1 - 0.091 12.7 5.9 0.13 12.2 5.9 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 ETO19197.1 - 5.3 5.2 6.8 6.4 4.9 6.8 1.1 1 0 0 1 1 1 0 CDC45-like protein TT_ORF1 PF02956.14 ETO19197.1 - 5.3 5.6 5.6 7.2 5.2 5.6 1.1 1 0 0 1 1 1 0 TT viral orf 1 CDC27 PF09507.10 ETO19197.1 - 6.9 5.9 7.2 9.2 5.5 7.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CENP-B_dimeris PF09026.10 ETO19199.1 - 7.7 7.0 25.0 11 6.5 25.0 1.4 1 1 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.14 ETO19199.1 - 8.9 4.5 10.0 9 4.4 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein YgaB PF14182.6 ETO19200.1 - 0.0041 17.5 1.3 0.012 16.0 1.3 1.8 1 0 0 1 1 1 1 YgaB-like protein Fer4_20 PF14691.6 ETO19200.1 - 0.03 14.1 0.8 0.057 13.2 0.8 1.4 1 0 0 1 1 1 0 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster DUF4806 PF16064.5 ETO19200.1 - 0.032 14.5 0.7 0.079 13.3 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) WD40 PF00400.32 ETO19201.1 - 3.7e-34 116.2 6.4 3.7e-08 33.9 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19201.1 - 7.7e-09 35.7 0.3 0.012 15.8 0.0 3.3 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19201.1 - 2.1e-06 26.9 0.1 0.084 11.8 0.0 3.7 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO19201.1 - 0.00038 19.9 0.0 0.22 10.8 0.0 2.1 2 0 0 2 2 2 2 WD40-like domain Str_synth PF03088.16 ETO19201.1 - 0.016 15.4 0.0 4.5 7.5 0.0 2.8 3 0 0 3 3 3 0 Strictosidine synthase Ricin_B_lectin PF00652.22 ETO19201.1 - 0.04 14.2 0.3 0.081 13.2 0.3 1.5 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain PD40 PF07676.12 ETO19201.1 - 0.14 12.1 0.3 3.7 7.6 0.1 2.5 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat YcxB PF14317.6 ETO19202.1 - 0.16 11.7 1.4 0.45 10.2 0.2 2.6 2 0 0 2 2 2 0 YcxB-like protein GMC_oxred_C PF05199.13 ETO19204.1 - 0.032 14.7 0.2 0.13 12.8 0.1 1.9 2 0 0 2 2 2 0 GMC oxidoreductase DER1 PF04511.15 ETO19205.1 - 6.9e-32 110.9 4.7 9.1e-32 110.5 4.6 1.2 1 1 0 1 1 1 1 Der1-like family PsbT PF01405.17 ETO19205.1 - 0.76 9.6 3.4 2.4 8.0 3.4 1.8 1 0 0 1 1 1 0 Photosystem II reaction centre T protein zf-DNA_Pol PF08996.10 ETO19206.1 - 3.9e-48 163.7 5.4 4.5e-48 163.4 5.4 1.0 1 0 0 1 1 1 1 DNA Polymerase alpha zinc finger zinc_ribbon_4 PF13717.6 ETO19206.1 - 0.024 14.6 0.3 0.067 13.1 0.3 1.8 1 0 0 1 1 1 0 zinc-ribbon domain YdjO PF14169.6 ETO19206.1 - 7.4 6.4 6.2 42 4.0 0.0 3.6 4 0 0 4 4 4 0 Cold-inducible protein YdjO Rib_5-P_isom_A PF06026.14 ETO19207.1 - 0.018 14.6 0.1 1.1 8.9 0.0 2.2 1 1 0 2 2 2 0 Ribose 5-phosphate isomerase A (phosphoriboisomerase A) Bap31 PF05529.12 ETO19207.1 - 0.021 14.7 1.9 1.4 8.7 0.1 2.3 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region DUF3377 PF11857.8 ETO19207.1 - 5.4 7.0 6.2 4.1 7.4 0.8 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF3377) WhiA_N PF10298.9 ETO19208.1 - 0.34 11.0 3.1 3 8.0 0.4 2.3 2 0 0 2 2 2 0 WhiA N-terminal LAGLIDADG-like domain PRCH PF03967.13 ETO19208.1 - 1.5 9.0 4.8 1.3 9.3 0.3 2.5 3 0 0 3 3 3 0 Photosynthetic reaction centre, H-chain N-terminal region TMEM247 PF15444.6 ETO19209.1 - 8.3 6.4 6.5 11 6.0 6.5 1.2 1 0 0 1 1 1 0 Transmembrane protein 247 ATP-synt_ab_C PF00306.27 ETO19210.1 - 1.4e-06 28.6 1.2 2.2e-06 28.0 1.2 1.3 1 0 0 1 1 1 1 ATP synthase alpha/beta chain, C terminal domain DcpS_C PF11969.8 ETO19210.1 - 0.039 14.4 1.0 0.039 14.4 1.0 2.3 2 1 1 3 3 3 0 Scavenger mRNA decapping enzyme C-term binding DUF2770 PF10968.8 ETO19210.1 - 0.55 10.2 4.2 2.3 8.2 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2770) Thiolase_N PF00108.23 ETO19211.1 - 6.9e-24 84.6 0.1 8.3e-24 84.3 0.1 1.1 1 0 0 1 1 1 1 Thiolase, N-terminal domain Acyl-CoA_dh_1 PF00441.24 ETO19212.1 - 2.1e-06 28.0 0.1 0.00031 21.0 0.1 2.2 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO19212.1 - 0.0011 19.2 0.1 0.32 11.2 0.0 2.4 1 1 1 2 2 2 2 Acyl-CoA dehydrogenase, middle domain ANAPC4_WD40 PF12894.7 ETO19214.1 - 0.00046 20.4 0.0 0.36 11.1 0.0 2.3 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO19214.1 - 0.00098 19.0 0.3 0.0041 17.0 0.4 2.0 1 1 1 2 2 2 1 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO19214.1 - 0.003 18.4 0.2 1.4 10.0 0.0 3.3 3 0 0 3 3 3 1 WD domain, G-beta repeat Tli4_C PF18426.1 ETO19215.1 - 0.033 14.5 0.4 0.076 13.3 0.4 1.6 1 0 0 1 1 1 0 Tle cognate immunity protein 4 C-terminal domain Zn_ribbon_17 PF17120.5 ETO19215.1 - 0.052 13.2 1.2 0.12 12.0 1.2 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4 PF00097.25 ETO19215.1 - 0.16 11.9 2.5 0.53 10.2 0.4 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO19215.1 - 0.51 10.3 3.5 0.24 11.4 0.6 1.9 2 0 0 2 2 2 0 zinc-RING finger domain zf-RING_2 PF13639.6 ETO19215.1 - 0.83 10.0 3.7 1.3 9.4 0.5 2.5 3 0 0 3 3 3 0 Ring finger domain Zip PF02535.22 ETO19215.1 - 0.88 8.7 14.1 0.054 12.7 5.2 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter NPR3 PF03666.13 ETO19215.1 - 1.8 7.2 15.2 1.9 7.2 10.5 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 DHHC PF01529.20 ETO19216.1 - 1.8e-21 76.6 6.7 2.4e-21 76.3 6.7 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase TCR_zetazeta PF11628.8 ETO19216.1 - 0.037 13.7 4.4 0.073 12.8 4.4 1.4 1 0 0 1 1 1 0 T-cell surface glycoprotein CD3 zeta chain XAP5 PF04921.14 ETO19217.1 - 2.2e-64 217.7 3.4 2.2e-64 217.7 3.4 2.6 1 1 1 2 2 2 1 XAP5, circadian clock regulator Histone PF00125.24 ETO19218.1 - 2.7e-42 144.2 0.9 4.3e-42 143.6 0.9 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CENP-T_C PF15511.6 ETO19218.1 - 0.0029 17.7 0.0 0.006 16.7 0.0 1.6 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold PAF PF15715.5 ETO19218.1 - 0.015 15.9 1.8 0.019 15.5 1.8 1.2 1 0 0 1 1 1 0 PCNA-associated factor histone like domain GCR1_C PF12550.8 ETO19218.1 - 0.045 14.1 0.0 0.079 13.3 0.0 1.3 1 0 0 1 1 1 0 Transcriptional activator of glycolytic enzymes CENP-S PF15630.6 ETO19218.1 - 0.1 13.0 0.1 0.18 12.2 0.1 1.3 1 0 0 1 1 1 0 CENP-S protein TMA7 PF09072.10 ETO19218.1 - 0.38 11.6 2.7 0.73 10.7 2.7 1.4 1 0 0 1 1 1 0 Translation machinery associated TMA7 Aminotran_5 PF00266.19 ETO19219.1 - 9.7e-29 100.5 0.0 1.4e-17 63.7 0.0 3.0 2 1 0 2 2 2 2 Aminotransferase class-V FAS_I_H PF18314.1 ETO19219.1 - 0.063 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Fatty acid synthase type I helical domain CDC45 PF02724.14 ETO19220.1 - 0.44 8.8 6.4 0.45 8.7 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_M56 PF05569.11 ETO19221.1 - 0.0041 16.3 0.1 0.0097 15.1 0.1 1.5 1 0 0 1 1 1 1 BlaR1 peptidase M56 Comm PF15957.5 ETO19221.1 - 0.28 11.5 0.1 0.28 11.5 0.1 2.8 3 0 0 3 3 3 0 Commissureless Mucin PF01456.17 ETO19221.1 - 5.8 6.9 23.1 0.23 11.5 14.7 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein ABC_tran PF00005.27 ETO19222.1 - 1.4e-06 28.9 0.5 1.4e-06 28.9 0.5 2.4 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ETO19222.1 - 0.032 14.1 0.3 0.032 14.1 0.3 1.9 2 1 1 3 3 3 0 RsgA GTPase AAA_28 PF13521.6 ETO19222.1 - 0.034 14.4 1.3 0.034 14.4 1.3 2.3 2 1 0 3 3 3 0 AAA domain AAA_25 PF13481.6 ETO19222.1 - 0.099 12.2 1.1 0.11 12.0 0.1 1.5 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO19222.1 - 0.11 13.0 0.1 0.11 13.0 0.1 2.6 2 1 1 3 3 3 0 AAA domain DUF87 PF01935.17 ETO19222.1 - 1.7 8.7 9.4 0.94 9.5 1.1 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain MMR_HSR1 PF01926.23 ETO19222.1 - 2.8 8.1 5.0 0.96 9.6 0.5 2.4 3 0 0 3 3 3 0 50S ribosome-binding GTPase ABC2_membrane PF01061.24 ETO19224.1 - 4.3e-15 55.7 20.6 4.3e-15 55.7 20.6 2.0 2 1 0 2 2 2 1 ABC-2 type transporter DEP PF00610.21 ETO19225.1 - 5.5e-08 32.8 0.2 1.4e-07 31.4 0.2 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CD99L2 PF12301.8 ETO19225.1 - 0.045 14.0 4.0 0.088 13.1 4.0 1.5 1 0 0 1 1 1 0 CD99 antigen like protein 2 CDC45 PF02724.14 ETO19225.1 - 0.67 8.2 10.4 0.97 7.6 10.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Glyco_hydro_85 PF03644.13 ETO19226.1 - 2.2e-51 175.1 0.1 4e-51 174.2 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 85 Glyco_hydro_18 PF00704.28 ETO19226.1 - 0.035 13.8 0.3 0.088 12.5 0.1 1.5 1 1 0 1 1 1 0 Glycosyl hydrolases family 18 UCH PF00443.29 ETO19227.1 - 5e-13 49.1 0.3 9.6e-13 48.2 0.3 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ETO19228.1 - 5.7e-51 169.4 19.2 1.3e-09 38.5 0.1 7.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19228.1 - 3.6e-27 94.5 4.8 0.0011 19.2 0.0 7.8 2 2 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19228.1 - 1.8e-13 50.2 0.9 0.073 12.0 0.0 6.3 2 1 5 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO19228.1 - 2.4e-05 24.4 10.6 1.8 9.0 0.0 6.4 7 0 0 7 7 6 3 Kelch motif Cytochrom_D1 PF02239.16 ETO19228.1 - 2.5e-05 23.0 1.1 0.016 13.8 0.2 3.3 1 1 3 4 4 4 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO19228.1 - 0.00011 21.1 8.9 0.51 8.9 0.0 5.4 2 1 3 5 5 5 2 Nucleoporin Nup120/160 Kelch_2 PF07646.15 ETO19228.1 - 0.0012 18.7 2.3 18 5.5 0.0 4.9 4 0 0 4 4 4 0 Kelch motif PD40 PF07676.12 ETO19228.1 - 0.0016 18.3 5.1 38 4.4 0.0 5.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO19228.1 - 0.002 17.8 0.5 0.081 12.5 0.5 2.9 1 1 0 1 1 1 1 PQQ-like domain Kelch_4 PF13418.6 ETO19228.1 - 0.0052 16.8 1.2 0.12 12.4 0.1 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Nbas_N PF15492.6 ETO19228.1 - 0.0063 15.9 0.5 3.1 7.0 0.0 3.7 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PQQ PF01011.21 ETO19228.1 - 0.0098 15.8 0.0 14 5.8 0.1 3.7 4 0 0 4 4 3 0 PQQ enzyme repeat Kelch_5 PF13854.6 ETO19228.1 - 0.38 10.8 4.0 22 5.2 0.5 4.0 4 0 0 4 4 4 0 Kelch motif GF_recep_IV PF14843.6 ETO19228.1 - 0.57 10.0 6.0 2.2 8.1 0.3 2.9 3 0 0 3 3 3 0 Growth factor receptor domain IV Proteasome_A_N PF10584.9 ETO19228.1 - 3 7.6 13.6 15 5.4 0.0 5.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO19229.1 - 5.7e-36 121.9 29.6 5e-07 30.3 0.5 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO19229.1 - 3.1e-14 52.5 5.6 0.00019 20.2 0.1 4.6 1 1 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO19229.1 - 3.4e-12 46.5 0.8 0.046 14.0 0.0 5.9 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO19229.1 - 0.0008 18.3 4.4 2.3 6.9 0.0 4.6 2 2 2 5 5 5 2 Nup133 N terminal like TetM_leader PF08076.11 ETO19229.1 - 0.55 10.1 6.6 31 4.4 0.1 4.4 5 0 0 5 5 5 0 Tetracycline resistance determinant leader peptide WD40 PF00400.32 ETO19230.1 - 1.6e-14 54.0 14.0 3.4e-06 27.7 0.1 4.3 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19230.1 - 0.00056 20.2 0.6 0.42 10.9 0.1 3.1 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19230.1 - 0.0016 17.2 0.8 0.22 10.1 0.0 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO19230.1 - 0.022 13.5 1.5 0.13 11.0 0.7 1.8 1 1 0 1 1 1 0 Nup133 N terminal like Read-through PF16814.5 ETO19230.1 - 0.041 13.7 0.1 0.057 13.2 0.1 1.3 1 0 0 1 1 1 0 Read-through domain WD40_like PF17005.5 ETO19230.1 - 0.072 12.4 0.6 0.25 10.6 0.1 2.1 2 1 0 2 2 2 0 WD40-like domain WD40 PF00400.32 ETO19231.1 - 3.5e-37 125.8 25.5 3.4e-06 27.7 0.4 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19231.1 - 2.1e-09 37.5 0.8 0.089 13.1 0.0 5.2 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19231.1 - 5.3e-09 35.3 5.6 0.029 13.0 0.0 4.7 1 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO19231.1 - 0.00036 20.0 8.0 0.095 12.0 0.3 4.0 2 2 2 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO19232.1 - 1.8e-38 129.8 24.0 2.7e-06 28.0 0.2 7.1 6 3 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19232.1 - 4.3e-12 46.2 2.3 0.014 15.6 0.0 5.6 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19232.1 - 9.4e-10 37.7 8.5 0.00011 21.0 0.6 5.1 1 1 4 5 5 5 5 Nucleoporin Nup120/160 Peptidase_C9 PF01707.16 ETO19232.1 - 0.032 13.8 0.1 0.092 12.3 0.1 1.8 2 0 0 2 2 2 0 Peptidase family C9 Integrin_B_tail PF07965.12 ETO19232.1 - 0.059 13.9 3.2 0.11 13.0 0.6 2.3 2 0 0 2 2 2 0 Integrin beta tail domain WD40 PF00400.32 ETO19233.1 - 1.3e-42 143.0 26.9 2.3e-07 31.4 0.0 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19233.1 - 3.1e-10 40.2 0.4 0.0099 16.2 0.0 5.3 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19233.1 - 3.5e-05 22.7 7.9 0.06 12.0 0.0 4.4 2 2 2 5 5 5 2 Nucleoporin Nup120/160 IFT57 PF10498.9 ETO19234.1 - 0.046 12.7 2.6 0.074 12.0 2.6 1.3 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF3736 PF12540.8 ETO19235.1 - 0.033 14.3 1.2 0.58 10.3 0.3 2.4 1 1 2 3 3 3 0 Protein of unknown function (DUF3736) KIP1 PF07765.12 ETO19235.1 - 0.21 11.7 5.0 0.45 10.7 4.7 1.8 1 1 0 1 1 1 0 KIP1-like protein SWIRM PF04433.17 ETO19235.1 - 0.27 11.6 3.9 0.7 10.3 3.9 1.9 1 1 0 1 1 1 0 SWIRM domain SBF_like PF13593.6 ETO19237.1 - 1.5e-16 60.6 10.8 1.8e-16 60.3 10.8 1.0 1 0 0 1 1 1 1 SBF-like CPA transporter family (DUF4137) Pkinase PF00069.25 ETO19238.1 - 1.5e-28 99.9 0.2 3.1e-15 56.3 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19238.1 - 1.9e-16 60.1 0.0 9.8e-07 28.3 0.0 3.1 2 1 1 3 3 3 3 Protein tyrosine kinase CDC45 PF02724.14 ETO19238.1 - 0.00078 17.9 16.0 0.00093 17.6 16.0 1.2 1 0 0 1 1 1 1 CDC45-like protein TFIIA PF03153.13 ETO19238.1 - 0.0016 18.5 16.1 0.0017 18.5 16.1 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Nop14 PF04147.12 ETO19238.1 - 0.0044 15.3 24.6 0.0057 15.0 24.6 1.1 1 0 0 1 1 1 1 Nop14-like family SAPS PF04499.15 ETO19238.1 - 0.0074 15.1 4.8 0.0067 15.3 4.8 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein DUF2457 PF10446.9 ETO19238.1 - 0.018 14.2 35.0 0.031 13.4 35.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BUD22 PF09073.10 ETO19238.1 - 0.13 11.6 25.6 0.2 11.0 25.6 1.3 1 0 0 1 1 1 0 BUD22 PPP4R2 PF09184.11 ETO19238.1 - 0.15 11.7 25.1 0.24 10.9 25.1 1.3 1 0 0 1 1 1 0 PPP4R2 Mpp10 PF04006.12 ETO19238.1 - 0.2 10.1 23.2 0.32 9.4 23.2 1.4 1 0 0 1 1 1 0 Mpp10 protein FAM60A PF15396.6 ETO19238.1 - 0.34 10.9 6.8 0.62 10.0 6.8 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Drc1-Sld2 PF11719.8 ETO19238.1 - 0.52 9.8 17.7 0.76 9.3 17.7 1.2 1 0 0 1 1 1 0 DNA replication and checkpoint protein DNA_pol_phi PF04931.13 ETO19238.1 - 1.1 7.3 36.7 1.6 6.8 36.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2722 PF10846.8 ETO19238.1 - 1.3 7.8 18.5 1.8 7.4 18.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF913 PF06025.12 ETO19238.1 - 1.6 7.6 5.6 2.1 7.2 5.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Dicty_REP PF05086.12 ETO19238.1 - 3.3 5.6 12.4 5.5 4.8 12.4 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SLC12 PF03522.15 ETO19238.1 - 5.5 5.9 6.5 8.4 5.3 6.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 ETO19238.1 - 7.5 5.2 7.4 9.7 4.8 7.4 1.1 1 0 0 1 1 1 0 Raftlin RRN3 PF05327.11 ETO19238.1 - 7.9 4.9 23.4 11 4.4 23.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 IFT57 PF10498.9 ETO19238.1 - 8.1 5.3 15.0 12 4.7 15.0 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Ras PF00071.22 ETO19239.1 - 4e-08 33.0 2.2 5e-08 32.7 2.2 1.2 1 0 0 1 1 1 1 Ras family Ribosomal_L30_N PF08079.12 ETO19239.1 - 0.0037 17.5 4.5 0.0037 17.5 4.5 2.6 1 1 1 2 2 2 1 Ribosomal L30 N-terminal domain Roc PF08477.13 ETO19239.1 - 0.0091 16.2 0.1 0.02 15.1 0.1 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SpoVT_C PF15714.5 ETO19239.1 - 0.16 12.0 2.0 0.16 12.1 1.0 1.4 1 1 0 1 1 1 0 Stage V sporulation protein T C-terminal, transcription factor UPF0565 PF10561.9 ETO19241.1 - 0.0028 16.9 9.2 0.0032 16.7 9.2 1.2 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 DDHD PF02862.17 ETO19241.1 - 0.01 16.0 6.4 0.012 15.8 6.4 1.1 1 0 0 1 1 1 0 DDHD domain Membralin PF09746.9 ETO19241.1 - 0.088 11.8 4.7 0.099 11.7 4.7 1.1 1 0 0 1 1 1 0 Tumour-associated protein Neur_chan_memb PF02932.16 ETO19241.1 - 0.12 12.4 1.5 0.15 12.1 1.5 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ETO19241.1 - 0.13 11.3 12.7 0.16 11.0 12.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CPSF100_C PF13299.6 ETO19241.1 - 0.32 11.2 8.5 0.52 10.5 8.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4175 PF13779.6 ETO19241.1 - 1.6 6.6 5.5 1.9 6.3 5.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Menin PF05053.13 ETO19241.1 - 1.9 6.8 15.6 2.6 6.3 15.6 1.2 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO19241.1 - 3 6.6 11.8 3.6 6.3 11.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter 7tm_1 PF00001.21 ETO19242.1 - 0.0055 16.1 1.8 0.007 15.7 1.8 1.2 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) Vma12 PF11712.8 ETO19242.1 - 0.0058 16.7 0.2 0.0077 16.3 0.2 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4448 PF14610.6 ETO19242.1 - 0.0083 15.9 0.1 0.013 15.3 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) Sld7_N PF18636.1 ETO19242.1 - 0.011 16.1 2.9 0.019 15.3 2.9 1.4 1 0 0 1 1 1 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain Orf78 PF06024.12 ETO19242.1 - 0.011 16.0 1.2 0.017 15.4 1.0 1.5 1 1 0 1 1 1 0 Orf78 (ac78) Peroxin-13_N PF04088.13 ETO19242.1 - 0.024 14.9 3.9 0.024 14.9 3.9 1.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region SNARE PF05739.19 ETO19242.1 - 0.13 12.3 0.2 0.13 12.3 0.2 2.0 2 0 0 2 2 2 0 SNARE domain NLRC4_HD PF17889.1 ETO19242.1 - 0.15 12.4 3.3 0.16 12.3 1.9 1.7 1 1 0 2 2 2 0 NLRC4 helical domain PrgI PF12666.7 ETO19242.1 - 0.85 10.4 5.9 0.19 12.4 2.3 1.7 2 1 0 2 2 2 0 PrgI family protein zf-AN1 PF01428.16 ETO19243.1 - 1.5e-05 25.0 0.6 1.5e-05 25.0 0.6 1.5 2 0 0 2 2 2 1 AN1-like Zinc finger G-patch PF01585.23 ETO19244.1 - 2.7e-07 30.4 0.4 5.6e-07 29.4 0.4 1.5 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ETO19244.1 - 0.047 13.8 0.0 0.13 12.4 0.0 1.8 1 0 0 1 1 1 0 G-patch domain DUF4187 PF13821.6 ETO19244.1 - 0.15 11.9 5.7 1.3 8.9 1.1 3.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4187) TPR_12 PF13424.6 ETO19245.1 - 9.8e-24 83.5 0.0 8.1e-14 51.7 0.0 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO19245.1 - 1.2e-10 40.9 0.0 0.00011 21.9 0.0 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO19245.1 - 3.6e-10 39.2 1.9 5.9e-05 22.7 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO19245.1 - 1.6e-09 37.1 1.1 0.0062 16.6 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19245.1 - 3.9e-09 36.0 2.0 0.0009 19.3 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO19245.1 - 2.6e-07 30.2 0.1 0.012 15.6 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO19245.1 - 2.5e-05 23.9 0.0 0.38 10.5 0.0 3.2 3 0 0 3 3 3 2 TPR repeat TPR_MalT PF17874.1 ETO19245.1 - 0.0015 18.0 0.0 0.0067 15.8 0.0 1.8 2 0 0 2 2 2 1 MalT-like TPR region ATP-synt_F PF01990.17 ETO19245.1 - 0.05 13.9 0.3 0.12 12.7 0.3 1.7 1 0 0 1 1 1 0 ATP synthase (F/14-kDa) subunit Bestrophin PF01062.21 ETO19245.1 - 0.08 12.3 1.3 2 7.7 0.4 2.2 1 1 0 2 2 2 0 Bestrophin, RFP-TM, chloride channel PGA2 PF07543.12 ETO19247.1 - 0.97 9.4 16.3 0.17 11.9 12.5 1.5 1 1 1 2 2 2 0 Protein trafficking PGA2 DUF4820 PF16091.5 ETO19247.1 - 1.5 8.1 8.2 1.6 8.0 8.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PPL5 PF18168.1 ETO19247.1 - 1.7 7.9 5.8 1.8 7.8 5.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 PCM1_C PF15717.5 ETO19247.1 - 2.2 6.9 13.4 2.4 6.7 13.4 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus AP3D1 PF06375.11 ETO19247.1 - 2.7 8.2 20.0 3.7 7.8 20.0 1.3 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4746 PF15928.5 ETO19247.1 - 2.8 7.3 12.2 3.4 7.0 12.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Pox_Ag35 PF03286.14 ETO19247.1 - 3.3 7.4 21.5 5.1 6.8 21.5 1.3 1 1 0 1 1 1 0 Pox virus Ag35 surface protein MRI PF15325.6 ETO19247.1 - 3.9 8.6 11.7 8.3 7.6 11.6 1.5 1 1 0 1 1 1 0 Modulator of retrovirus infection Eapp_C PF10238.9 ETO19247.1 - 5.5 7.1 12.1 7.2 6.7 12.1 1.4 1 1 0 1 1 1 0 E2F-associated phosphoprotein Ion_trans PF00520.31 ETO19248.1 - 1.6e-39 135.7 10.7 9.1e-37 126.6 6.5 2.0 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 ETO19248.1 - 0.31 9.6 10.9 0.55 8.8 0.3 3.0 2 1 1 3 3 3 0 Polycystin cation channel Lectin_C PF00059.21 ETO19249.1 - 7.1e-18 65.3 19.0 3e-17 63.3 2.8 4.3 4 0 0 4 4 4 2 Lectin C-type domain Fibrinogen_C PF00147.18 ETO19249.1 - 0.00014 21.7 0.2 0.00042 20.2 0.1 1.9 1 1 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain PAN_3 PF08277.12 ETO19249.1 - 0.54 10.1 6.7 0.25 11.2 3.0 2.4 2 0 0 2 2 2 0 PAN-like domain tRNA-synt_1d PF00750.19 ETO19250.1 - 6.1e-22 78.0 0.7 7.7e-20 71.1 0.1 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (R) Rpn3_C PF08375.11 ETO19250.1 - 0.012 16.0 1.3 0.081 13.4 2.2 1.9 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal Rad4 PF03835.15 ETO19250.1 - 0.04 13.6 2.7 0.058 13.1 2.7 1.3 1 0 0 1 1 1 0 Rad4 transglutaminase-like domain Chisel PF15355.6 ETO19250.1 - 0.28 11.4 1.4 0.5 10.6 1.4 1.3 1 0 0 1 1 1 0 Stretch-responsive small skeletal muscle X protein, Chisel DUF908 PF06012.12 ETO19252.1 - 0.0005 19.6 5.5 0.23 10.8 6.8 2.1 1 1 0 2 2 2 2 Domain of Unknown Function (DUF908) YmaF PF12788.7 ETO19252.1 - 0.02 15.4 1.6 0.02 15.4 1.6 2.8 2 1 1 3 3 3 0 YmaF family RNA_pol_Rpc4 PF05132.14 ETO19252.1 - 1.1 9.7 7.7 0.35 11.3 4.9 1.5 2 0 0 2 2 2 0 RNA polymerase III RPC4 Ras PF00071.22 ETO19253.1 - 2.1e-56 190.0 0.3 2.4e-56 189.8 0.3 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO19253.1 - 5.6e-33 113.7 0.4 2.2e-32 111.8 0.0 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO19253.1 - 6.2e-14 51.8 0.0 8e-14 51.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO19253.1 - 1.7e-05 24.3 0.2 8.8e-05 22.0 0.2 1.9 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO19253.1 - 0.013 15.6 0.0 0.019 15.0 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase Phage_integrase PF00589.22 ETO19253.1 - 0.025 14.4 0.1 0.035 13.9 0.1 1.1 1 0 0 1 1 1 0 Phage integrase family GTP_EFTU PF00009.27 ETO19253.1 - 0.087 12.4 0.0 0.22 11.0 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain PTEN_C2 PF10409.9 ETO19254.1 - 0.00054 19.7 0.1 0.0018 18.0 0.1 1.9 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein EXS PF03124.14 ETO19255.1 - 2e-26 93.1 2.8 2.3e-26 92.9 2.8 1.0 1 0 0 1 1 1 1 EXS family Pkinase PF00069.25 ETO19256.1 - 5.8e-44 150.4 0.0 7.4e-44 150.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19256.1 - 2e-17 63.4 0.0 2.5e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO19256.1 - 1.7e-06 27.6 0.0 2.3e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO19256.1 - 5.3e-06 25.9 0.4 8.2e-06 25.3 0.4 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO19256.1 - 0.0061 15.5 0.0 0.0093 14.9 0.0 1.2 1 0 0 1 1 1 1 Haspin like kinase domain YrbL-PhoP_reg PF10707.9 ETO19256.1 - 0.024 14.2 0.0 0.038 13.5 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ETO19256.1 - 0.085 11.6 0.0 0.12 11.1 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase Pet20 PF08692.10 ETO19257.1 - 0.18 12.5 0.5 0.18 12.5 0.5 2.0 2 0 0 2 2 2 0 Mitochondrial protein Pet20 Mucin PF01456.17 ETO19258.1 - 0.089 12.8 27.1 0.18 11.8 27.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 ETO19258.1 - 5.5 5.0 15.5 10 4.1 15.5 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Glyco_hydro_47 PF01532.20 ETO19262.1 - 8.5e-28 97.4 0.1 1e-27 97.2 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 HEAT PF02985.22 ETO19263.1 - 1.7e-09 37.1 6.3 0.01 16.1 0.2 4.6 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ETO19263.1 - 1.4e-06 28.7 0.3 0.096 13.2 0.0 3.5 3 0 0 3 3 3 2 HEAT-like repeat CLASP_N PF12348.8 ETO19263.1 - 5e-05 23.0 0.2 0.2 11.2 0.0 2.3 2 0 0 2 2 2 2 CLASP N terminal HEAT_2 PF13646.6 ETO19263.1 - 0.00013 22.3 2.1 0.00089 19.6 0.3 2.5 2 1 0 2 2 2 1 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO19263.1 - 0.00021 21.8 1.2 0.041 14.5 0.3 2.6 2 1 0 2 2 2 1 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETO19263.1 - 0.0012 18.9 0.3 0.063 13.3 0.2 2.8 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 MMS19_C PF12460.8 ETO19263.1 - 0.017 14.3 0.0 0.22 10.6 0.0 2.1 2 0 0 2 2 2 0 RNAPII transcription regulator C-terminal TIP120 PF08623.10 ETO19263.1 - 0.02 14.7 0.1 0.56 10.0 0.1 2.5 2 1 0 2 2 2 0 TATA-binding protein interacting (TIP20) HEM4 PF02602.15 ETO19264.1 - 0.026 13.9 1.7 0.033 13.5 1.7 1.1 1 0 0 1 1 1 0 Uroporphyrinogen-III synthase HemD DUF1387 PF07139.11 ETO19264.1 - 0.11 12.2 11.9 0.12 12.0 11.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) TFIIF_alpha PF05793.12 ETO19264.1 - 0.17 10.4 9.5 0.18 10.3 9.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FSA_C PF10479.9 ETO19264.1 - 0.28 9.3 9.9 0.28 9.3 9.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus FAM76 PF16046.5 ETO19264.1 - 1.1 8.6 11.4 1.2 8.5 11.4 1.1 1 0 0 1 1 1 0 FAM76 protein SSP160 PF06933.11 ETO19264.1 - 1.2 7.2 19.5 1.3 7.1 19.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4612 PF15389.6 ETO19264.1 - 1.9 9.6 9.4 2.2 9.4 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4612) Rtf2 PF04641.12 ETO19264.1 - 2.4 7.4 11.5 2.8 7.3 11.5 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger Asp PF00026.23 ETO19265.1 - 1e-07 31.7 0.1 1.4e-07 31.2 0.1 1.3 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_C PF14541.6 ETO19265.1 - 0.012 15.3 0.0 0.52 10.1 0.0 2.3 2 0 0 2 2 2 0 Xylanase inhibitor C-terminal F5_F8_type_C PF00754.25 ETO19266.1 - 0.00018 21.6 6.5 0.0037 17.4 0.0 3.3 4 0 0 4 4 4 2 F5/8 type C domain Sad1_UNC PF07738.13 ETO19266.1 - 0.0044 17.0 7.2 2.2 8.3 0.4 4.0 4 0 0 4 4 4 2 Sad1 / UNC-like C-terminal RIFIN PF02009.16 ETO19267.1 - 2.3e-05 24.5 8.6 3.2e-05 24.0 8.6 1.3 1 0 0 1 1 1 1 Rifin DUF5305 PF17231.2 ETO19267.1 - 0.001 18.5 4.0 0.0021 17.5 3.3 1.8 2 0 0 2 2 2 1 Family of unknown function (DUF5305) Neur_chan_memb PF02932.16 ETO19267.1 - 0.0063 16.6 2.8 0.0089 16.1 2.8 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region DUF1676 PF07898.13 ETO19267.1 - 0.0072 16.4 3.1 0.0072 16.4 3.1 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1676) DUF2207 PF09972.9 ETO19267.1 - 0.016 14.0 6.4 0.0052 15.6 3.3 1.7 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) TraG_N PF07916.11 ETO19267.1 - 0.033 13.0 0.7 0.043 12.7 0.7 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region T2SSF PF00482.23 ETO19267.1 - 0.088 12.8 3.2 0.21 11.6 3.2 1.7 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF3377 PF11857.8 ETO19267.1 - 0.34 10.8 5.9 1.2 9.1 5.9 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) ABC2_membrane_3 PF12698.7 ETO19267.1 - 0.43 9.6 11.5 0.3 10.1 7.9 2.0 2 0 0 2 2 2 0 ABC-2 family transporter protein Orf78 PF06024.12 ETO19267.1 - 1.9 8.8 20.2 0.67 10.3 10.0 3.2 2 1 1 3 3 3 0 Orf78 (ac78) GWT1 PF06423.12 ETO19267.1 - 10 6.3 7.3 33 4.6 4.2 2.6 1 1 0 2 2 2 0 GWT1 Pkinase PF00069.25 ETO19268.1 - 1.7e-17 63.7 4.9 6.2e-17 61.8 4.9 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19268.1 - 4.6e-14 52.3 1.4 1.5e-13 50.7 1.4 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO19268.1 - 0.00089 18.1 0.2 0.00098 18.0 0.3 1.3 1 1 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO19268.1 - 0.0064 16.4 0.1 0.0095 15.9 0.1 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO19268.1 - 0.0077 15.9 0.4 0.022 14.4 0.1 1.8 2 0 0 2 2 2 1 RIO1 family UPF0449 PF15136.6 ETO19269.1 - 0.32 11.5 13.0 0.46 11.0 3.4 2.9 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 RecG_N PF17190.4 ETO19269.1 - 1.7 9.4 14.0 0.38 11.5 2.9 3.4 1 1 2 3 3 3 0 RecG N-terminal helical domain Fungal_trans_2 PF11951.8 ETO19269.1 - 2.4 6.9 7.4 1 8.1 4.7 1.7 2 0 0 2 2 2 0 Fungal specific transcription factor domain ANAPC4_WD40 PF12894.7 ETO19270.1 - 6e-05 23.3 0.0 0.087 13.1 0.0 3.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain BUD22 PF09073.10 ETO19270.1 - 7.6e-05 22.2 30.0 7.6e-05 22.2 30.0 2.2 2 0 0 2 2 2 1 BUD22 PQQ_3 PF13570.6 ETO19270.1 - 0.0002 21.7 0.2 0.89 10.1 0.0 3.5 3 0 0 3 3 3 2 PQQ-like domain RAB3GAP2_N PF14655.6 ETO19270.1 - 0.02 14.2 0.1 0.02 14.2 0.1 1.9 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Rrn6 PF10214.9 ETO19270.1 - 0.041 12.4 11.1 0.087 11.3 11.1 1.5 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor WD40 PF00400.32 ETO19270.1 - 0.061 14.2 0.2 1.7 9.6 0.0 3.5 3 0 0 3 3 3 0 WD domain, G-beta repeat PQQ_2 PF13360.6 ETO19270.1 - 0.11 12.0 0.0 0.82 9.2 0.0 2.3 3 0 0 3 3 3 0 PQQ-like domain Borrelia_P83 PF05262.11 ETO19270.1 - 0.65 8.4 18.7 0.97 7.8 18.7 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CDC27 PF09507.10 ETO19270.1 - 4.9 6.4 42.5 9.8 5.4 42.5 1.4 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 ETO19271.1 - 0.062 12.1 14.0 0.11 11.2 14.0 1.5 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 ETO19271.1 - 0.36 9.2 1.6 0.53 8.6 1.6 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Trypan_PARP PF05887.11 ETO19271.1 - 2.2 8.3 9.2 5.8 6.9 9.2 1.7 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Smg8_Smg9 PF10220.9 ETO19271.1 - 2.5 6.3 13.6 4 5.6 13.6 1.3 1 0 0 1 1 1 0 Smg8_Smg9 Membralin PF09746.9 ETO19271.1 - 6.7 5.6 8.2 13 4.7 8.2 1.4 1 0 0 1 1 1 0 Tumour-associated protein AAA_11 PF13086.6 ETO19271.1 - 7.1 6.3 20.0 15 5.3 20.0 1.5 1 0 0 1 1 1 0 AAA domain MDM10 PF12519.8 ETO19271.1 - 7.5 5.3 14.4 12 4.6 14.4 1.4 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 GREB1 PF15782.5 ETO19271.1 - 8.2 3.4 10.2 11 3.0 10.2 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3169 PF11368.8 ETO19272.1 - 0.014 15.0 0.1 0.024 14.2 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) RPEL PF02755.15 ETO19273.1 - 5.8e-09 35.4 40.6 0.0028 17.3 0.7 11.2 13 0 0 13 13 13 5 RPEL repeat PC_rep PF01851.22 ETO19273.1 - 0.18 12.3 0.1 12 6.6 0.0 3.2 3 0 0 3 3 3 0 Proteasome/cyclosome repeat Exo_endo_phos PF03372.23 ETO19275.1 - 0.023 14.2 0.0 0.034 13.7 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family MMR1 PF08505.10 ETO19275.1 - 0.38 11.0 6.4 0.61 10.3 6.4 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Peptidase_S9 PF00326.21 ETO19276.1 - 0.011 15.2 0.0 3.2 7.2 0.0 2.2 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 ETO19276.1 - 0.013 15.1 0.0 0.018 14.7 0.0 1.2 1 0 0 1 1 1 0 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 ETO19276.1 - 0.065 12.5 0.0 6.3 6.0 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 RRM_1 PF00076.22 ETO19277.1 - 2.5e-14 52.8 0.0 0.0016 18.2 0.0 6.0 6 0 0 6 6 6 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mif2_N PF15624.6 ETO19277.1 - 0.032 14.9 0.7 0.1 13.3 0.7 1.8 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal RRM_occluded PF16842.5 ETO19277.1 - 0.06 13.2 1.4 4.6 7.2 0.0 3.6 4 0 0 4 4 4 0 Occluded RNA-recognition motif Cul7 PF11515.8 ETO19278.1 - 0.00047 20.4 0.3 0.79 10.1 0.0 2.3 2 0 0 2 2 2 2 Mouse development and cellular proliferation protein Cullin-7 Phage_base_V PF04717.12 ETO19278.1 - 0.11 12.4 0.2 6.1 6.8 0.1 2.2 2 0 0 2 2 2 0 Type VI secretion system, phage-baseplate injector KOW PF00467.29 ETO19278.1 - 0.14 12.2 0.1 4.4 7.4 0.0 2.3 2 0 0 2 2 2 0 KOW motif PPR_2 PF13041.6 ETO19279.1 - 0.00072 19.7 0.0 0.076 13.2 0.0 2.6 2 0 0 2 2 2 1 PPR repeat family PPR PF01535.20 ETO19279.1 - 0.011 16.0 0.1 0.037 14.3 0.1 2.0 1 0 0 1 1 1 0 PPR repeat PPR_1 PF12854.7 ETO19279.1 - 0.036 13.8 0.0 0.11 12.2 0.0 1.9 2 0 0 2 2 2 0 PPR repeat Skp1 PF01466.19 ETO19280.1 - 0.58 10.3 4.6 10 6.3 0.0 3.5 3 0 0 3 3 3 0 Skp1 family, dimerisation domain Glyco_transf_34 PF05637.12 ETO19283.1 - 6.5e-23 81.7 5.4 6.5e-23 81.7 5.4 1.9 2 1 0 2 2 2 1 galactosyl transferase GMA12/MNN10 family Glyco_tranf_2_4 PF13704.6 ETO19283.1 - 0.079 13.5 0.2 0.3 11.6 0.1 2.0 2 0 0 2 2 2 0 Glycosyl transferase family 2 COX4 PF02936.14 ETO19283.1 - 0.74 9.8 5.7 0.11 12.5 0.5 2.2 3 0 0 3 3 3 0 Cytochrome c oxidase subunit IV Presenilin PF01080.17 ETO19284.1 - 0.23 10.2 1.1 0.24 10.1 1.1 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 ETO19284.1 - 0.58 9.6 4.3 0.73 9.3 4.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3433 PF11915.8 ETO19285.1 - 0.0078 16.6 0.1 0.013 16.0 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3433) CDK5_activator PF03261.15 ETO19285.1 - 1.2 8.6 20.5 1.6 8.2 20.5 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Hid1 PF12722.7 ETO19285.1 - 1.4 6.9 8.5 1.9 6.5 8.5 1.3 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF5111 PF17138.4 ETO19286.1 - 0.1 12.5 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5111) AvrPtoB-E3_ubiq PF09046.10 ETO19286.1 - 0.18 12.1 0.7 11 6.3 0.2 2.5 2 1 0 2 2 2 0 AvrPtoB E3 ubiquitin ligase DUF551 PF04448.12 ETO19288.1 - 0.021 15.7 1.9 0.021 15.7 1.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF551) VHL PF01847.16 ETO19289.1 - 0.057 13.3 0.0 0.088 12.7 0.0 1.3 1 0 0 1 1 1 0 VHL beta domain DnaJ PF00226.31 ETO19290.1 - 2.7e-18 65.8 0.6 5e-18 65.0 0.6 1.5 1 0 0 1 1 1 1 DnaJ domain DUF1980 PF09323.10 ETO19291.1 - 0.74 9.7 3.4 6.5 6.6 1.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) HELP PF03451.14 ETO19292.1 - 4.4e-09 36.1 0.0 9.7e-09 35.0 0.0 1.6 1 0 0 1 1 1 1 HELP motif WD40 PF00400.32 ETO19292.1 - 0.0083 17.0 1.5 0.4 11.6 0.1 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat Trypan_glycop_C PF10659.9 ETO19292.1 - 0.59 10.5 3.9 0.28 11.6 0.8 2.1 2 1 0 2 2 2 0 Trypanosome variant surface glycoprotein C-terminal domain ANAPC4_WD40 PF12894.7 ETO19293.1 - 0.0052 17.1 0.0 0.12 12.7 0.0 2.8 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO19293.1 - 0.043 14.7 6.2 3.2 8.8 0.2 4.9 5 0 0 5 5 5 0 WD domain, G-beta repeat Nup160 PF11715.8 ETO19293.1 - 0.063 11.9 0.1 6.6 5.2 0.0 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Afi1 PF07792.12 ETO19294.1 - 2.1e-07 31.5 0.6 3.5e-07 30.8 0.6 1.3 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Vfa1 PF08432.10 ETO19294.1 - 0.35 11.2 6.1 0.48 10.7 6.1 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2457 PF10446.9 ETO19294.1 - 0.56 9.3 11.5 0.73 8.9 11.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO19294.1 - 0.9 7.8 5.3 1.2 7.4 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO19295.1 - 0.16 10.7 2.9 0.14 10.9 2.9 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO19295.1 - 0.57 9.3 3.1 0.7 9.0 3.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO19295.1 - 1.3 7.3 12.7 2 6.7 12.7 1.4 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO19295.1 - 1.7 7.4 5.1 2 7.2 5.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NST1 PF13945.6 ETO19295.1 - 3.3 7.8 20.7 5.1 7.2 20.7 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Macoilin PF09726.9 ETO19295.1 - 5.7 5.4 14.5 6.8 5.1 14.5 1.1 1 0 0 1 1 1 0 Macoilin family APG6_N PF17675.1 ETO19297.1 - 0.0029 18.2 2.4 0.0029 18.2 2.4 3.4 2 1 1 3 3 3 1 Apg6 coiled-coil region DUF4407 PF14362.6 ETO19297.1 - 0.016 14.6 24.4 0.13 11.6 5.9 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF485 PF04341.12 ETO19297.1 - 0.067 13.1 0.5 0.82 9.7 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function, DUF485 SPG48 PF14764.6 ETO19297.1 - 0.17 12.4 2.5 4.3 7.8 0.3 2.9 2 0 0 2 2 2 0 AP-5 complex subunit, vesicle trafficking Peptidase_Prp PF04327.12 ETO19297.1 - 0.41 10.9 10.6 0.64 10.3 0.1 3.4 2 2 0 2 2 2 0 Cysteine protease Prp DUF4917 PF16263.5 ETO19297.1 - 0.44 9.8 6.7 0.16 11.3 0.2 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF4917) IpaB_EvcA PF03278.13 ETO19297.1 - 0.5 10.1 5.7 6.9 6.4 5.5 2.6 1 1 0 1 1 1 0 IpaB/EvcA family Sec34 PF04136.15 ETO19297.1 - 0.64 9.9 25.3 0.061 13.2 3.6 3.7 2 1 0 3 3 3 0 Sec34-like family LMBR1 PF04791.16 ETO19297.1 - 2.3 7.0 18.5 1 8.2 0.2 2.1 1 1 1 2 2 2 0 LMBR1-like membrane protein ERM PF00769.19 ETO19297.1 - 2.8 7.7 35.8 2 8.2 21.6 2.5 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Fez1 PF06818.15 ETO19297.1 - 2.9 8.3 31.1 2 8.8 16.0 2.9 2 1 0 2 2 2 0 Fez1 IF3_C PF00707.22 ETO19297.1 - 5.1 7.1 10.7 0.81 9.7 0.4 3.7 5 0 0 5 5 5 0 Translation initiation factor IF-3, C-terminal domain Exonuc_VII_L PF02601.15 ETO19297.1 - 5.6 6.4 23.5 1.7 8.1 1.0 2.3 1 1 1 2 2 2 0 Exonuclease VII, large subunit L71 PF02448.15 ETO19297.1 - 6.3 7.3 8.5 3 8.3 0.2 3.6 3 1 1 4 4 4 0 L71 family DUF5074 PF16819.5 ETO19299.1 - 0.0068 16.4 0.4 0.42 10.7 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF5074) Tachylectin PF14517.6 ETO19299.1 - 0.062 12.8 0.4 2.9 7.3 0.0 2.3 2 0 0 2 2 2 0 Tachylectin AbfS_sensor PF18225.1 ETO19299.1 - 0.18 11.7 0.0 28 4.7 0.0 2.5 2 0 0 2 2 2 0 Sensor histidine kinase (AbfS) sensor domain Ubiquitin_2 PF14560.6 ETO19301.1 - 7.6e-08 32.7 0.1 1.9e-07 31.4 0.1 1.7 1 0 0 1 1 1 1 Ubiquitin-like domain FmiP_Thoc5 PF09766.9 ETO19301.1 - 0.078 12.3 3.6 0.18 11.1 3.6 1.6 1 1 0 1 1 1 0 Fms-interacting protein/Thoc5 Metallophos PF00149.28 ETO19302.1 - 2.3e-10 41.4 3.4 3.3e-10 40.8 3.4 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO19302.1 - 4.1e-06 27.1 0.0 9.6e-06 25.9 0.0 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Metallophos_3 PF14582.6 ETO19302.1 - 0.00052 19.4 0.0 0.011 15.0 0.0 2.0 2 0 0 2 2 2 1 Metallophosphoesterase, calcineurin superfamily DUF2142 PF09913.9 ETO19303.1 - 0.18 10.6 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) TMEM154 PF15102.6 ETO19304.1 - 0.22 11.4 8.6 0.062 13.2 1.0 2.5 2 0 0 2 2 2 0 TMEM154 protein family Tmemb_9 PF05434.11 ETO19304.1 - 0.81 9.6 6.5 0.22 11.4 2.8 2.0 2 0 0 2 2 2 0 TMEM9 DUF4834 PF16118.5 ETO19304.1 - 3.6 8.6 5.5 0.9 10.5 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) UDPG_MGDP_dh_N PF03721.14 ETO19306.1 - 6.6e-51 172.6 0.1 7.5e-51 172.4 0.1 1.0 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain NAD_binding_2 PF03446.15 ETO19306.1 - 4.9e-07 30.1 0.1 5.2e-06 26.7 0.1 2.0 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 3HCDH_N PF02737.18 ETO19306.1 - 2.1e-05 24.5 0.2 3.1e-05 24.0 0.2 1.3 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain ApbA PF02558.16 ETO19306.1 - 0.0022 17.7 0.1 0.0062 16.2 0.1 1.7 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA 2-Hacid_dh_C PF02826.19 ETO19306.1 - 0.0027 17.1 0.1 0.0041 16.5 0.1 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ETO19306.1 - 0.024 13.8 0.1 0.032 13.4 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase TrkA_N PF02254.18 ETO19306.1 - 0.025 14.8 0.4 0.04 14.2 0.4 1.5 1 1 0 1 1 1 0 TrkA-N domain NAD_Gly3P_dh_N PF01210.23 ETO19306.1 - 0.038 14.0 0.1 0.051 13.5 0.1 1.3 1 0 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus SBP_bac_11 PF13531.6 ETO19306.1 - 0.039 13.7 0.2 0.15 11.8 0.0 1.8 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Pyr_redox PF00070.27 ETO19306.1 - 0.12 12.9 0.3 0.23 12.1 0.3 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Epimerase PF01370.21 ETO19306.1 - 0.17 11.3 0.0 0.24 10.9 0.0 1.4 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family K_channel_TID PF07941.11 ETO19307.1 - 0.0013 19.1 1.5 0.0013 19.1 1.5 2.8 2 0 0 2 2 2 2 Potassium channel Kv1.4 tandem inactivation domain DUF913 PF06025.12 ETO19308.1 - 0.00069 18.7 0.7 0.00094 18.3 0.7 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) DUF2457 PF10446.9 ETO19308.1 - 0.2 10.7 19.4 0.24 10.5 19.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SDA1 PF05285.12 ETO19308.1 - 0.82 9.0 15.5 1 8.7 15.5 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO19308.1 - 1.1 7.5 9.0 1.2 7.3 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO19308.1 - 1.4 6.9 15.1 1.8 6.6 15.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETO19308.1 - 4.3 5.8 9.1 5.3 5.5 9.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 ETO19308.1 - 5.7 6.2 14.2 11 5.3 14.2 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RCC1 PF00415.18 ETO19311.1 - 2.8e-30 104.7 13.2 6.1e-08 33.2 0.1 8.2 6 3 0 6 6 6 6 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO19311.1 - 3.9e-20 71.1 10.6 1.7e-08 34.0 2.1 6.0 7 0 0 7 7 7 4 Regulator of chromosome condensation (RCC1) repeat RGS PF00615.19 ETO19312.1 - 0.096 13.0 3.6 0.51 10.6 1.2 2.9 2 1 0 2 2 2 0 Regulator of G protein signaling domain CBM9_2 PF16011.5 ETO19313.1 - 0.051 13.3 0.1 0.083 12.6 0.1 1.3 1 0 0 1 1 1 0 Carbohydrate-binding family 9 Cys_Met_Meta_PP PF01053.20 ETO19314.1 - 0.0016 17.1 0.0 0.0025 16.4 0.0 1.3 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_5 PF00266.19 ETO19314.1 - 0.0077 15.2 0.1 1.9 7.4 0.0 2.6 2 1 0 2 2 2 2 Aminotransferase class-V Pyridoxal_deC PF00282.19 ETO19314.1 - 0.022 13.5 0.1 0.08 11.6 0.1 1.8 1 1 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain RAB3GAP2_N PF14655.6 ETO19316.1 - 1.3e-20 74.1 0.1 4.6e-10 39.3 0.0 2.3 2 0 0 2 2 2 2 Rab3 GTPase-activating protein regulatory subunit N-terminus KLRAQ PF10205.9 ETO19316.1 - 0.37 11.1 3.2 13 6.1 0.5 3.1 3 0 0 3 3 3 0 Predicted coiled-coil domain-containing protein Nucleotid_trans PF03407.16 ETO19317.1 - 1.9e-19 70.5 0.7 2.7e-19 70.0 0.7 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase HP0268 PF18618.1 ETO19318.1 - 0.047 14.1 0.0 0.084 13.3 0.0 1.3 1 0 0 1 1 1 0 HP0268 DUF2180 PF09947.9 ETO19318.1 - 0.18 11.8 0.2 0.57 10.2 0.1 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2180) Aminotran_1_2 PF00155.21 ETO19319.1 - 2.1e-24 86.4 0.0 2.3e-24 86.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETO19319.1 - 0.055 12.7 0.0 0.071 12.4 0.0 1.1 1 0 0 1 1 1 0 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ETO19319.1 - 0.093 11.2 0.0 0.093 11.2 0.0 1.2 1 0 0 1 1 1 0 Cys/Met metabolism PLP-dependent enzyme Ank_2 PF12796.7 ETO19320.1 - 1.4e-21 76.8 2.9 1.2e-07 32.2 0.1 3.4 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO19320.1 - 4.6e-21 74.9 0.5 0.0012 19.4 0.0 6.6 1 1 6 7 7 7 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO19320.1 - 1.1e-18 65.3 2.4 0.0012 19.2 0.0 6.4 6 0 0 6 6 6 5 Ankyrin repeat Ank PF00023.30 ETO19320.1 - 4.3e-16 58.5 3.7 0.0016 18.8 0.0 6.0 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ETO19320.1 - 1.1e-15 57.5 5.0 6.4e-06 26.3 0.1 5.4 3 2 2 5 5 5 4 Ankyrin repeats (many copies) Pkinase_Tyr PF07714.17 ETO19321.1 - 5.1e-38 130.8 0.0 2.3e-29 102.4 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO19321.1 - 4.9e-25 88.4 1.4 7.7e-17 61.5 0.0 2.5 2 1 1 3 3 3 2 Protein kinase domain Apc15p PF05841.11 ETO19321.1 - 0.015 16.1 10.4 0.029 15.2 10.4 1.4 1 0 0 1 1 1 0 Apc15p protein CSG2 PF16965.5 ETO19321.1 - 0.29 10.0 2.6 0.4 9.6 2.6 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Menin PF05053.13 ETO19321.1 - 0.4 9.0 10.3 0.53 8.6 10.3 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO19321.1 - 0.82 10.3 17.9 1.8 9.2 17.9 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain NST1 PF13945.6 ETO19321.1 - 3.9 7.5 17.1 6.5 6.8 17.1 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator UCH PF00443.29 ETO19323.1 - 1.9e-08 34.1 1.2 1.9e-08 34.1 1.2 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Frag1 PF10277.9 ETO19323.1 - 0.023 14.2 0.2 0.038 13.5 0.2 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family IstB_IS21_ATP PF08483.11 ETO19324.1 - 0.077 12.9 0.9 8.7 6.3 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding N-terminal DUF5036 PF16439.5 ETO19324.1 - 0.082 12.6 0.2 0.11 12.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5036) SlyX PF04102.12 ETO19326.1 - 0.032 14.8 0.4 0.047 14.3 0.4 1.4 1 0 0 1 1 1 0 SlyX DASH_Spc19 PF08287.11 ETO19326.1 - 0.26 11.1 7.3 0.51 10.2 7.3 1.6 1 1 0 1 1 1 0 Spc19 SAM_2 PF07647.17 ETO19327.1 - 0.021 14.9 0.1 7.3 6.8 0.0 2.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) AAA_23 PF13476.6 ETO19327.1 - 0.022 15.3 0.9 0.022 15.3 0.9 2.0 1 1 1 2 2 2 0 AAA domain DUF244 PF03112.14 ETO19327.1 - 0.073 12.9 1.0 0.14 12.0 0.3 1.8 2 0 0 2 2 2 0 Uncharacterized protein family (ORF7) DUF PHF12_MRG_bd PF16737.5 ETO19327.1 - 0.1 12.4 0.5 0.19 11.5 0.5 1.5 1 0 0 1 1 1 0 PHD finger protein 12 MRG binding domain Hydrolase_4 PF12146.8 ETO19328.1 - 4.8e-49 166.8 0.0 9.2e-49 165.9 0.0 1.4 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO19328.1 - 1.3e-07 31.6 0.0 4.5e-07 29.8 0.0 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_5 PF12695.7 ETO19328.1 - 2.6e-06 27.3 0.0 4.5e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 ETO19328.1 - 5.7e-06 27.1 0.0 6.2e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase PF00756.20 ETO19328.1 - 0.00014 21.6 0.0 0.00018 21.3 0.0 1.2 1 0 0 1 1 1 1 Putative esterase Peptidase_S9 PF00326.21 ETO19328.1 - 0.00021 20.8 0.0 0.0004 19.9 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Thioesterase PF00975.20 ETO19328.1 - 0.00056 20.1 0.0 0.0031 17.7 0.0 1.9 2 0 0 2 2 2 1 Thioesterase domain MIT PF04212.18 ETO19328.1 - 0.041 14.0 1.1 0.077 13.1 1.1 1.4 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain PGAP1 PF07819.13 ETO19328.1 - 0.067 12.9 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Lipase_3 PF01764.25 ETO19328.1 - 0.07 13.0 0.0 0.19 11.6 0.0 1.7 1 0 0 1 1 1 0 Lipase (class 3) Abhydrolase_8 PF06259.12 ETO19328.1 - 0.12 12.0 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Alpha/beta hydrolase Ubie_methyltran PF01209.18 ETO19328.1 - 0.14 11.5 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Med26_C PF15693.5 ETO19329.1 - 0.073 13.2 0.1 0.19 11.9 0.1 1.6 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal CNP1 PF08750.11 ETO19330.1 - 0.054 13.5 0.1 0.13 12.2 0.1 1.6 1 0 0 1 1 1 0 CNP1-like family UCH PF00443.29 ETO19331.1 - 2.8e-07 30.3 0.8 6.3e-07 29.1 0.8 1.6 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Helicase_C PF00271.31 ETO19332.1 - 0.0026 18.1 0.4 0.0068 16.7 0.4 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF5645 PF18713.1 ETO19332.1 - 0.009 16.3 0.2 0.024 15.0 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5645) DUF418 PF04235.12 ETO19332.1 - 0.025 14.5 0.3 0.45 10.4 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF418) Claudin_3 PF06653.11 ETO19332.1 - 0.17 11.8 8.1 0.18 11.7 7.0 1.6 2 0 0 2 2 2 0 Tight junction protein, Claudin-like FixQ PF05545.11 ETO19332.1 - 4.2 7.4 8.6 2.4 8.2 0.1 2.9 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ zf-C2H2_2 PF12756.7 ETO19335.1 - 0.0031 17.8 2.3 0.0031 17.8 2.3 2.1 2 0 0 2 2 2 1 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ETO19335.1 - 0.018 15.7 0.3 0.018 15.7 0.3 1.6 2 0 0 2 2 2 0 Zinc finger C2H2-type, 3 repeats Zn-ribbon_8 PF09723.10 ETO19335.1 - 0.024 14.7 0.4 0.055 13.6 0.4 1.5 1 0 0 1 1 1 0 Zinc ribbon domain 2OG-FeII_Oxy PF03171.20 ETO19336.1 - 3.9e-16 59.4 0.0 5.7e-16 58.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily LmjF365940-deam PF14421.6 ETO19337.1 - 3.2e-19 69.3 0.2 5.6e-19 68.5 0.2 1.3 1 0 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases BBS1 PF14779.6 ETO19337.1 - 0.0013 18.3 1.6 0.0016 18.0 1.6 1.1 1 0 0 1 1 1 1 Ciliary BBSome complex subunit 1 YqzL PF14006.6 ETO19337.1 - 0.021 15.2 0.5 0.071 13.5 0.5 1.9 1 0 0 1 1 1 0 YqzL-like protein LEAP-2 PF07359.11 ETO19337.1 - 0.094 12.6 0.1 1.1 9.2 0.0 2.2 1 1 1 2 2 2 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) DUF2547 PF10818.8 ETO19337.1 - 0.15 13.0 0.7 1.5 9.8 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2547) GMC_oxred_N PF00732.19 ETO19338.1 - 4.1e-19 69.1 0.0 4.9e-10 39.3 0.0 2.1 2 0 0 2 2 2 2 GMC oxidoreductase GRIN_C PF15235.6 ETO19342.1 - 0.82 9.9 5.1 4.1 7.6 5.1 1.9 1 1 0 1 1 1 0 G protein-regulated inducer of neurite outgrowth C-terminus MMPL PF03176.15 ETO19344.1 - 1e-14 54.2 0.8 2.4e-08 33.3 0.1 2.1 2 0 0 2 2 2 2 MMPL family G-alpha PF00503.20 ETO19345.1 - 2.1e-07 30.5 1.4 7.1e-07 28.7 0.0 1.9 1 1 1 2 2 2 1 G-protein alpha subunit DUF1389 PF07146.11 ETO19345.1 - 0.033 13.5 0.3 0.033 13.5 0.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1389) Hydin_ADK PF17213.3 ETO19345.1 - 0.097 12.9 1.8 9.5 6.4 0.0 2.1 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Menin PF05053.13 ETO19345.1 - 0.23 9.8 3.7 0.29 9.5 3.7 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO19345.1 - 0.98 10.0 12.1 1.6 9.3 12.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain VPS9 PF02204.18 ETO19346.1 - 2.2e-10 40.7 0.3 6.7e-10 39.1 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain O-antigen_lig PF13425.6 ETO19346.1 - 0.0023 16.8 5.3 0.0029 16.5 5.3 1.2 1 0 0 1 1 1 1 O-antigen ligase like membrane protein Peptidase_S49_N PF08496.10 ETO19346.1 - 0.042 13.9 0.6 0.076 13.1 0.6 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Shisa PF13908.6 ETO19346.1 - 0.16 12.2 0.1 0.25 11.6 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4446 PF14584.6 ETO19346.1 - 0.18 11.8 1.5 1.3 9.0 1.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) EphA2_TM PF14575.6 ETO19346.1 - 0.24 12.3 2.1 0.59 11.1 2.1 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4834 PF16118.5 ETO19346.1 - 1.2 10.1 8.8 3.5 8.7 7.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4064 PF13273.6 ETO19346.1 - 6 7.2 7.1 12 6.2 7.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) DUF5385 PF17359.2 ETO19346.1 - 6.8 6.2 14.8 0.89 9.1 10.2 1.8 1 1 0 1 1 1 0 Family of unknown function (DUF5385) PaaA_PaaC PF05138.12 ETO19347.1 - 0.0027 16.9 1.3 0.0034 16.6 1.3 1.2 1 0 0 1 1 1 1 Phenylacetic acid catabolic protein BST2 PF16716.5 ETO19348.1 - 0.0091 16.6 1.5 0.0091 16.6 1.5 3.3 2 2 1 3 3 2 1 Bone marrow stromal antigen 2 HrpB7 PF09486.10 ETO19348.1 - 0.011 16.1 18.4 0.072 13.5 9.5 2.1 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) CENP-F_leu_zip PF10473.9 ETO19348.1 - 0.015 15.3 2.4 0.015 15.3 2.4 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TPR_MLP1_2 PF07926.12 ETO19348.1 - 0.13 12.4 25.7 0.098 12.7 14.3 3.0 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO19348.1 - 0.13 11.6 8.4 1.4 8.2 5.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) HOOK PF05622.12 ETO19348.1 - 0.14 10.3 23.3 0.77 7.8 23.3 1.8 1 1 0 1 1 1 0 HOOK protein CALCOCO1 PF07888.11 ETO19348.1 - 0.32 9.8 23.7 0.65 8.8 2.5 2.0 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF4618 PF15397.6 ETO19348.1 - 0.47 9.8 18.0 1.2 8.5 1.6 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) SHE3 PF17078.5 ETO19348.1 - 0.9 9.2 22.5 2.1 8.0 10.5 2.1 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 Fmp27_WPPW PF10359.9 ETO19348.1 - 1.3 7.8 18.6 0.16 10.8 7.4 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain LRRFIP PF09738.9 ETO19348.1 - 1.3 8.4 22.8 1.4 8.3 10.3 2.1 2 0 0 2 2 2 0 LRRFIP family JIP_LZII PF16471.5 ETO19348.1 - 1.5 9.0 16.8 0.89 9.8 9.2 2.8 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II Jnk-SapK_ap_N PF09744.9 ETO19348.1 - 2.3 8.4 25.7 2.3 8.4 3.8 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 NRBF2 PF08961.10 ETO19348.1 - 2.5 7.7 16.7 0.42 10.2 1.5 2.3 2 0 0 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator Spc7 PF08317.11 ETO19348.1 - 2.9 6.7 24.5 1.6 7.6 12.9 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein OmpH PF03938.14 ETO19348.1 - 3 8.2 26.7 6 7.2 4.3 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) E2F_CC-MB PF16421.5 ETO19348.1 - 3.3 8.1 9.7 0.4 11.1 4.2 2.2 2 1 0 2 2 2 0 E2F transcription factor CC-MB domain ADIP PF11559.8 ETO19348.1 - 4.5 7.3 30.6 2.3 8.3 3.1 2.5 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding Spc24 PF08286.11 ETO19348.1 - 5.5 7.3 16.3 3.7 7.8 8.7 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF2968 PF11180.8 ETO19348.1 - 7.2 6.2 20.0 0.4 10.3 11.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) APG6_N PF17675.1 ETO19348.1 - 7.7 7.1 28.9 2.4 8.7 17.5 2.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DASH_Spc19 PF08287.11 ETO19348.1 - 9.7 6.1 23.1 0.37 10.7 12.0 2.5 2 1 0 2 2 2 0 Spc19 CCDC53 PF10152.9 ETO19350.1 - 6.1e-06 26.7 5.9 0.00046 20.6 0.1 2.5 2 1 0 2 2 2 2 Subunit CCDC53 of WASH complex FH2 PF02181.23 ETO19350.1 - 8.7e-06 25.1 6.9 1.7e-05 24.1 6.7 1.5 1 1 1 2 2 2 1 Formin Homology 2 Domain WD40 PF00400.32 ETO19351.1 - 3e-06 27.9 3.6 0.036 14.9 0.0 4.4 5 0 0 5 5 5 3 WD domain, G-beta repeat DUF2670 PF10875.8 ETO19351.1 - 1.2 9.2 4.4 0.66 10.1 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2670) Methyltransf_PK PF05891.12 ETO19352.1 - 1.2e-32 113.2 0.3 1.4e-32 113.0 0.3 1.1 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Methyltransf_25 PF13649.6 ETO19352.1 - 0.00013 22.6 0.0 0.00025 21.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO19352.1 - 0.0043 17.8 0.0 0.0075 17.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain mRNA_stabil PF13929.6 ETO19352.1 - 0.026 13.5 1.8 0.032 13.2 1.8 1.1 1 0 0 1 1 1 0 mRNA stabilisation Methyltransf_11 PF08241.12 ETO19352.1 - 0.066 13.9 0.0 0.11 13.1 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Sec1 PF00995.23 ETO19353.1 - 3.9e-32 112.2 1.3 4.9e-32 111.9 1.3 1.0 1 0 0 1 1 1 1 Sec1 family Peptidase_C1 PF00112.23 ETO19354.1 - 4.5e-65 219.8 16.7 5.4e-65 219.5 16.7 1.0 1 0 0 1 1 1 1 Papain family cysteine protease Peptidase_C1_2 PF03051.15 ETO19354.1 - 2e-07 30.1 1.0 0.00052 18.9 0.2 2.1 2 0 0 2 2 2 2 Peptidase C1-like family Cofilin_ADF PF00241.20 ETO19355.1 - 2.8e-24 85.3 2.8 7.5e-13 48.3 0.5 2.6 2 1 0 2 2 2 2 Cofilin/tropomyosin-type actin-binding protein rRNA_methylase PF06962.12 ETO19355.1 - 0.022 14.7 0.0 0.044 13.8 0.0 1.4 1 0 0 1 1 1 0 Putative rRNA methylase TLD PF07534.16 ETO19356.1 - 5.5e-27 94.7 0.0 1.4e-26 93.4 0.0 1.7 1 0 0 1 1 1 1 TLD Inhibitor_I29 PF08246.12 ETO19357.1 - 2.7e-11 43.7 2.7 5e-11 42.9 2.7 1.4 1 0 0 1 1 1 1 Cathepsin propeptide inhibitor domain (I29) ABC_membrane PF00664.23 ETO19357.1 - 0.00019 21.1 0.1 0.00029 20.6 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region Peptidase_M75 PF09375.10 ETO19358.1 - 0.00041 19.9 0.7 0.00049 19.7 0.7 1.1 1 0 0 1 1 1 1 Imelysin DUF1179 PF06678.11 ETO19358.1 - 0.0035 17.3 0.5 0.0061 16.5 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1179) DUF2868 PF11067.8 ETO19358.1 - 0.031 13.8 0.5 0.038 13.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) DUF5305 PF17231.2 ETO19358.1 - 0.097 12.1 3.8 0.14 11.5 3.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Pkinase PF00069.25 ETO19359.1 - 8.7e-05 22.0 0.0 0.00019 20.9 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19359.1 - 0.0006 19.2 0.0 0.00068 19.0 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase NACHT PF05729.12 ETO19360.1 - 0.0018 18.2 0.0 0.0032 17.4 0.0 1.4 1 0 0 1 1 1 1 NACHT domain RsgA_GTPase PF03193.16 ETO19360.1 - 0.012 15.5 0.0 0.014 15.3 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_22 PF13401.6 ETO19360.1 - 0.014 15.6 0.0 0.033 14.4 0.0 1.7 1 1 1 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO19360.1 - 0.026 15.1 0.3 0.19 12.2 0.0 2.2 1 1 1 2 2 2 0 AAA domain Pox_A32 PF04665.12 ETO19360.1 - 0.046 13.2 0.0 0.079 12.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus A32 protein DUF2515 PF10720.9 ETO19360.1 - 0.065 12.4 0.2 0.084 12.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2515) AAA_30 PF13604.6 ETO19360.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain Helicase_C PF00271.31 ETO19362.1 - 5.4e-27 94.3 2.1 1.1e-26 93.3 0.0 2.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO19362.1 - 1.8e-08 34.3 0.0 7.9e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 DEAD/DEAH box helicase DUF4633 PF15464.6 ETO19362.1 - 0.88 9.7 8.5 0.063 13.4 1.6 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4633) Rrn6 PF10214.9 ETO19363.1 - 0.0068 15.0 12.7 0.0071 14.9 12.7 1.0 1 0 0 1 1 1 1 RNA polymerase I-specific transcription-initiation factor Spc7_N PF15402.6 ETO19363.1 - 0.2 9.9 18.7 0.26 9.5 18.7 1.0 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 Macoilin PF09726.9 ETO19363.1 - 0.53 8.8 24.1 0.63 8.5 24.1 1.0 1 0 0 1 1 1 0 Macoilin family Borrelia_P83 PF05262.11 ETO19363.1 - 1 7.7 9.3 1.2 7.6 9.3 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Roughex PF06020.11 ETO19363.1 - 1.1 8.3 7.8 1.4 8.0 7.8 1.1 1 0 0 1 1 1 0 Drosophila roughex protein MAP65_ASE1 PF03999.12 ETO19363.1 - 1.2 7.7 13.5 1.5 7.5 13.5 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Menin PF05053.13 ETO19363.1 - 1.7 6.9 8.3 2.1 6.6 8.3 1.1 1 0 0 1 1 1 0 Menin PAT1 PF09770.9 ETO19363.1 - 2.9 6.1 19.1 3.4 5.8 19.1 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 TMEM51 PF15345.6 ETO19363.1 - 3.6 7.4 12.2 5 6.9 12.2 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 Dicty_REP PF05086.12 ETO19363.1 - 4.3 5.2 12.7 5.2 4.9 12.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF2681 PF10883.8 ETO19363.1 - 5.3 7.5 10.4 1.3 9.5 7.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) MAT1 PF06391.13 ETO19363.1 - 5.9 6.7 13.2 7.1 6.4 13.2 1.1 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Drf_GBD PF06371.13 ETO19363.1 - 8.8 5.8 12.2 0.13 11.8 0.5 2.1 1 1 1 2 2 2 0 Diaphanous GTPase-binding Domain RCC1 PF00415.18 ETO19364.1 - 8e-25 87.2 0.6 6e-13 49.2 0.0 4.2 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO19364.1 - 2.3e-14 52.8 4.1 0.00026 20.7 0.2 4.3 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat HNF-1_N PF04814.13 ETO19364.1 - 0.04 14.5 10.4 0.047 14.3 5.9 2.2 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus WW_1 PF18507.1 ETO19364.1 - 0.33 10.7 1.0 1.2 8.9 0.2 2.1 2 0 0 2 2 2 0 WW domain FAM176 PF14851.6 ETO19364.1 - 0.62 9.7 7.5 2.7 7.7 0.3 2.6 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 ETO19364.1 - 0.82 10.1 0.0 0.82 10.1 0.0 2.6 2 1 0 2 2 2 0 Centromere protein B dimerisation domain Cullin PF00888.22 ETO19365.1 - 6.6e-18 64.7 2.7 7.1e-18 64.6 2.7 1.0 1 0 0 1 1 1 1 Cullin family SRP54 PF00448.22 ETO19367.1 - 3e-54 183.7 1.5 6.2e-54 182.6 1.5 1.5 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain NTPase_1 PF03266.15 ETO19367.1 - 3.8e-08 33.4 0.3 2e-05 24.5 0.3 2.4 1 1 0 1 1 1 1 NTPase AAA_16 PF13191.6 ETO19367.1 - 3e-07 31.0 0.1 4.3e-07 30.5 0.1 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_30 PF13604.6 ETO19367.1 - 9.3e-06 25.5 0.2 1.4e-05 24.9 0.2 1.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO19367.1 - 9.5e-06 25.9 0.0 1.6e-05 25.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain MeaB PF03308.16 ETO19367.1 - 0.0002 20.5 0.2 0.00061 18.8 0.1 1.9 2 1 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA PF00004.29 ETO19367.1 - 0.00021 21.7 0.0 0.0004 20.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 ETO19367.1 - 0.00049 20.1 0.0 0.0019 18.2 0.0 1.9 1 1 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain ATP_bind_1 PF03029.17 ETO19367.1 - 0.00069 19.5 0.2 0.016 15.0 0.2 2.1 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein RsgA_GTPase PF03193.16 ETO19367.1 - 0.00088 19.2 0.1 0.14 12.1 0.0 2.9 2 1 1 3 3 3 1 RsgA GTPase AAA_17 PF13207.6 ETO19367.1 - 0.00089 19.7 0.0 0.0014 19.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ETO19367.1 - 0.0011 19.0 0.4 0.0047 17.0 0.4 2.0 1 1 0 1 1 1 1 50S ribosome-binding GTPase AAA_19 PF13245.6 ETO19367.1 - 0.0017 18.7 0.1 0.0038 17.6 0.1 1.5 1 1 0 1 1 1 1 AAA domain Thiamine_BP PF01910.17 ETO19367.1 - 0.003 17.4 0.0 0.0055 16.6 0.0 1.4 1 0 0 1 1 1 1 Thiamine-binding protein KdpD PF02702.17 ETO19367.1 - 0.0074 15.8 0.2 0.032 13.7 0.1 1.9 2 0 0 2 2 2 1 Osmosensitive K+ channel His kinase sensor domain DUF2075 PF09848.9 ETO19367.1 - 0.0083 15.4 0.1 0.011 15.0 0.1 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_28 PF13521.6 ETO19367.1 - 0.01 16.1 0.0 0.014 15.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain DAP3 PF10236.9 ETO19367.1 - 0.01 15.0 0.0 0.015 14.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_24 PF13479.6 ETO19367.1 - 0.011 15.5 0.0 0.037 13.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain MobB PF03205.14 ETO19367.1 - 0.013 15.4 0.1 0.04 13.8 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 ETO19367.1 - 0.015 15.5 0.1 0.025 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO19367.1 - 0.026 14.4 0.0 0.058 13.3 0.0 1.7 1 1 0 1 1 1 0 NACHT domain cobW PF02492.19 ETO19367.1 - 0.027 14.1 0.5 0.059 13.0 0.5 1.5 1 1 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Glyco_trans_4_2 PF13477.6 ETO19367.1 - 0.028 14.4 0.0 1.1 9.2 0.0 2.3 1 1 0 1 1 1 0 Glycosyl transferase 4-like KAP_NTPase PF07693.14 ETO19367.1 - 0.034 13.4 0.1 0.086 12.1 0.1 1.7 1 1 0 1 1 1 0 KAP family P-loop domain Zeta_toxin PF06414.12 ETO19367.1 - 0.039 13.2 0.1 0.093 12.0 0.1 1.7 1 1 0 1 1 1 0 Zeta toxin AAA_14 PF13173.6 ETO19367.1 - 0.042 13.9 0.0 0.11 12.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain CLP1_P PF16575.5 ETO19367.1 - 0.067 13.0 0.1 0.44 10.3 0.0 2.0 2 0 0 2 2 2 0 mRNA cleavage and polyadenylation factor CLP1 P-loop 6PF2K PF01591.18 ETO19367.1 - 0.1 11.9 0.1 0.16 11.3 0.1 1.4 1 1 0 1 1 1 0 6-phosphofructo-2-kinase SPOUT_MTase PF02590.17 ETO19367.1 - 0.11 12.5 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase YqgF PF14639.6 ETO19367.1 - 0.12 12.1 0.1 0.47 10.2 0.1 1.9 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 HSDR_N PF04313.14 ETO19367.1 - 0.13 12.1 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) ABC_tran PF00005.27 ETO19367.1 - 0.14 12.7 0.0 0.23 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter AAA_15 PF13175.6 ETO19367.1 - 0.25 11.0 0.0 0.33 10.6 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain EF-hand_6 PF13405.6 ETO19368.1 - 0.0017 18.1 0.2 0.048 13.6 0.0 3.2 4 0 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 ETO19368.1 - 0.0021 18.5 0.4 0.0021 18.5 0.4 3.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 ETO19368.1 - 0.031 14.1 1.1 0.041 13.7 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain pair DUF3439 PF11921.8 ETO19368.1 - 0.11 12.5 0.5 0.18 11.7 0.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Thymosin PF01290.20 ETO19368.1 - 0.23 11.2 6.4 6 6.7 0.1 2.8 2 0 0 2 2 2 0 Thymosin beta-4 family EF-hand_1 PF00036.32 ETO19368.1 - 0.32 10.7 2.2 1.3 8.7 0.0 3.1 4 0 0 4 4 4 0 EF hand DUF3482 PF11981.8 ETO19368.1 - 0.74 9.1 5.6 0.21 11.0 1.6 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3482) Cauli_AT PF03233.13 ETO19368.1 - 3.5 7.5 6.6 0.95 9.4 2.9 1.9 1 1 0 2 2 2 0 Aphid transmission protein EcsC PF12787.7 ETO19368.1 - 9.9 5.7 9.0 7.2 6.2 1.2 2.1 1 1 1 2 2 2 0 EcsC protein family Ank_2 PF12796.7 ETO19369.1 - 6e-12 46.0 0.1 6.3e-11 42.7 0.0 2.2 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO19369.1 - 4.1e-10 40.0 0.8 7.8e-05 23.2 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO19369.1 - 0.0002 21.5 0.0 0.22 12.2 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ETO19369.1 - 0.00048 20.5 0.1 0.016 15.6 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO19369.1 - 0.01 16.1 0.0 0.038 14.3 0.0 2.0 1 1 0 1 1 1 0 Ankyrin repeats (many copies) Phage_holin_3_6 PF07332.11 ETO19369.1 - 0.78 9.8 2.7 2.6 8.1 2.7 1.8 1 1 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Shisa PF13908.6 ETO19370.1 - 0.00068 19.9 2.7 0.00072 19.8 2.7 1.1 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FAM163 PF15069.6 ETO19370.1 - 0.0075 16.7 1.4 0.0077 16.7 1.4 1.1 1 0 0 1 1 1 1 FAM163 family EphA2_TM PF14575.6 ETO19370.1 - 0.011 16.6 0.1 0.012 16.5 0.1 1.1 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain TMEM52 PF14979.6 ETO19370.1 - 0.013 15.4 1.0 0.014 15.3 1.0 1.2 1 0 0 1 1 1 0 Transmembrane 52 CD34_antigen PF06365.12 ETO19370.1 - 0.014 15.0 0.1 0.014 15.0 0.1 1.1 1 0 0 1 1 1 0 CD34/Podocalyxin family ETRAMP PF09716.10 ETO19370.1 - 1.1 9.3 12.2 5.6 7.1 12.2 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) V-SNARE PF05008.15 ETO19371.1 - 1.9e-08 34.5 6.9 2.1e-08 34.4 2.1 2.5 2 0 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ETO19371.1 - 4.3e-07 30.1 1.6 1.1e-06 28.8 0.2 2.2 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO19371.1 - 0.0011 18.8 2.0 0.33 10.9 0.1 2.6 2 1 0 2 2 2 2 Sec20 PilJ PF13675.6 ETO19371.1 - 0.0013 18.8 3.7 0.0041 17.1 0.0 2.8 1 1 1 3 3 3 1 Type IV pili methyl-accepting chemotaxis transducer N-term Use1 PF09753.9 ETO19371.1 - 0.075 12.7 12.7 0.11 12.2 12.7 1.2 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF1213 PF06740.12 ETO19371.1 - 0.077 13.6 0.6 3.1 8.5 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1213) Bcr-Abl_Oligo PF09036.10 ETO19371.1 - 0.11 12.5 1.9 0.24 11.4 0.5 2.2 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF1664 PF07889.12 ETO19371.1 - 0.17 12.0 6.8 5.5 7.1 0.4 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) SCP1201-deam PF14428.6 ETO19371.1 - 0.23 11.3 1.8 0.39 10.6 0.7 2.0 2 1 0 2 2 2 0 SCP1.201-like deaminase SesA PF17107.5 ETO19371.1 - 0.38 10.9 5.7 0.17 12.0 1.1 2.3 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF4407 PF14362.6 ETO19371.1 - 0.45 9.8 7.1 0.6 9.4 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 ETO19371.1 - 0.52 9.1 10.3 0.62 8.8 10.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Moulting_cycle PF04870.16 ETO19371.1 - 2 7.6 15.3 2.6 7.2 15.3 1.1 1 0 0 1 1 1 0 Moulting cycle XhlA PF10779.9 ETO19371.1 - 5 7.4 8.8 9.1 6.6 3.0 2.7 2 0 0 2 2 2 0 Haemolysin XhlA YgaB PF14182.6 ETO19371.1 - 7.3 7.1 11.1 0.34 11.3 3.2 2.7 2 2 2 4 4 4 0 YgaB-like protein PH PF00169.29 ETO19372.1 - 8.1e-11 42.4 1.5 1.1e-10 41.9 0.3 1.7 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ETO19372.1 - 0.00014 21.9 1.4 0.0028 17.7 1.0 2.2 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO19372.1 - 0.00016 21.9 1.3 0.00065 19.9 1.3 2.1 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 ETO19372.1 - 0.035 14.5 0.1 0.035 14.5 0.1 2.0 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH_13 PF16652.5 ETO19372.1 - 0.061 13.1 1.5 0.072 12.9 0.1 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain PH_11 PF15413.6 ETO19372.1 - 0.56 10.7 7.2 0.12 12.8 1.8 2.4 1 1 1 2 2 2 0 Pleckstrin homology domain MAT1 PF06391.13 ETO19373.1 - 0.0088 15.9 7.8 0.009 15.9 7.8 1.0 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 Radial_spoke PF04712.12 ETO19373.1 - 0.026 13.5 9.3 0.025 13.5 9.3 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein IPPT PF01715.17 ETO19373.1 - 0.057 13.2 2.1 0.068 13.0 2.1 1.0 1 0 0 1 1 1 0 IPP transferase Sigma70_ner PF04546.13 ETO19373.1 - 0.17 11.7 10.7 0.21 11.5 10.7 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region CAC1F_C PF16885.5 ETO19373.1 - 0.28 10.8 6.6 0.31 10.7 6.6 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term XAP5 PF04921.14 ETO19373.1 - 0.32 10.8 7.3 0.34 10.7 7.3 1.1 1 0 0 1 1 1 0 XAP5, circadian clock regulator CobT PF06213.12 ETO19373.1 - 0.47 9.8 10.1 0.51 9.7 10.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_1B_p101 PF10486.9 ETO19373.1 - 0.53 8.0 7.9 0.5 8.1 7.9 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CENP-B_dimeris PF09026.10 ETO19373.1 - 0.63 10.5 9.8 0.82 10.1 9.8 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO19373.1 - 0.65 8.0 11.2 0.67 8.0 11.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Sporozoite_P67 PF05642.11 ETO19373.1 - 1 7.4 6.2 1 7.4 6.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM163 PF15069.6 ETO19373.1 - 1 9.8 6.0 1.3 9.5 6.0 1.1 1 0 0 1 1 1 0 FAM163 family CDC45 PF02724.14 ETO19373.1 - 1.3 7.2 9.6 1.4 7.1 9.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 ETO19373.1 - 1.8 8.3 10.4 2 8.2 10.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO19373.1 - 4.3 6.6 12.5 6.3 6.0 12.5 1.3 1 0 0 1 1 1 0 NOA36 protein CAP_N PF01213.19 ETO19374.1 - 0.32 10.4 2.7 0.57 9.6 2.7 1.3 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 ETO19374.1 - 0.5 10.4 3.3 1.1 9.3 3.3 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 uDENN PF03456.18 ETO19377.1 - 0.00045 20.9 0.3 0.0042 17.8 0.0 2.5 2 0 0 2 2 2 1 uDENN domain ALIX_LYPXL_bnd PF13949.6 ETO19377.1 - 0.05 12.9 0.3 0.064 12.5 0.3 1.2 1 0 0 1 1 1 0 ALIX V-shaped domain binding to HIV Spc7 PF08317.11 ETO19378.1 - 0.00069 18.6 12.2 0.00093 18.2 11.9 1.4 1 1 0 1 1 1 1 Spc7 kinetochore protein OmpH PF03938.14 ETO19378.1 - 0.021 15.1 10.9 0.043 14.2 10.3 1.7 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Lzipper-MIP1 PF14389.6 ETO19378.1 - 0.023 15.0 6.3 0.057 13.7 0.8 2.7 2 1 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 DUF3847 PF12958.7 ETO19378.1 - 0.026 14.6 2.5 0.026 14.6 2.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3847) Syntaphilin PF15290.6 ETO19378.1 - 0.051 13.2 15.4 0.06 13.0 8.9 2.0 1 1 1 2 2 2 0 Golgi-localised syntaxin-1-binding clamp Herpes_UL25 PF01499.16 ETO19378.1 - 0.081 11.4 3.7 0.049 12.2 2.2 1.3 1 1 0 1 1 1 0 Herpesvirus UL25 family CCDC92 PF14916.6 ETO19378.1 - 0.084 12.7 5.0 0.48 10.2 2.0 2.9 2 0 0 2 2 2 0 Coiled-coil domain of unknown function Filament PF00038.21 ETO19378.1 - 0.091 12.3 11.5 0.093 12.3 6.7 2.1 1 1 1 2 2 2 0 Intermediate filament protein Rab5-bind PF09311.11 ETO19378.1 - 0.11 11.8 13.2 0.16 11.4 12.9 1.3 1 1 0 1 1 1 0 Rabaptin-like protein BLOC1_2 PF10046.9 ETO19378.1 - 0.17 12.2 8.5 0.9 9.9 8.5 2.1 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Tup_N PF08581.10 ETO19378.1 - 0.26 11.6 12.1 1 9.7 1.4 2.6 1 1 1 2 2 2 0 Tup N-terminal LMBR1 PF04791.16 ETO19378.1 - 0.42 9.5 5.7 0.49 9.2 5.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein Cnn_1N PF07989.11 ETO19378.1 - 0.63 10.2 9.8 0.36 11.0 5.2 2.5 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 Lge1 PF11488.8 ETO19378.1 - 0.77 10.0 10.1 4.8 7.4 1.8 2.6 1 1 1 2 2 2 0 Transcriptional regulatory protein LGE1 DUF3552 PF12072.8 ETO19378.1 - 0.91 8.9 12.8 0.28 10.6 10.2 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3552) V_ATPase_I PF01496.19 ETO19378.1 - 1.1 7.0 9.9 1.2 7.0 9.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 ETO19378.1 - 2.2 8.1 7.0 1.5 8.7 2.8 2.3 1 1 0 2 2 2 0 Septum formation initiator TMPIT PF07851.13 ETO19378.1 - 3.1 7.0 8.3 3.9 6.6 8.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein APG6_N PF17675.1 ETO19378.1 - 4 8.0 16.8 0.34 11.4 9.6 2.4 3 0 0 3 3 3 0 Apg6 coiled-coil region ABC_tran_CTD PF16326.5 ETO19378.1 - 4.1 7.7 11.6 8.5e+02 0.3 10.8 2.8 1 1 0 1 1 1 0 ABC transporter C-terminal domain ALMT PF11744.8 ETO19378.1 - 4.8 5.9 13.9 5.4 5.7 13.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 ETO19380.1 - 3.2e-45 151.2 15.9 2.1e-09 37.9 0.4 6.3 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19380.1 - 2.1e-19 69.6 0.8 3.6e-05 24.0 0.0 5.1 1 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19380.1 - 1.5e-15 57.0 1.5 0.0031 16.5 0.0 5.8 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO19380.1 - 2.1e-05 24.0 2.4 0.048 13.0 0.1 3.9 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO19380.1 - 9.4e-05 22.2 12.1 5.7 7.0 0.0 5.9 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO19380.1 - 0.0004 19.2 1.0 0.19 10.3 0.0 3.4 2 2 2 4 4 4 2 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO19380.1 - 0.011 14.5 0.1 20 3.8 0.0 3.9 2 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO19380.1 - 0.039 14.1 2.1 5.4 7.1 0.1 3.8 2 1 2 4 4 4 0 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO19380.1 - 0.047 12.6 0.1 1.2 7.9 0.0 2.5 2 1 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) HARP PF07443.13 ETO19380.1 - 0.049 13.3 0.3 6.9 6.4 0.0 3.3 3 0 0 3 3 3 0 HepA-related protein (HARP) TolB_N PF04052.13 ETO19380.1 - 0.061 13.5 0.0 60 3.9 0.0 3.8 4 0 0 4 4 4 0 TolB amino-terminal domain BBS2_Mid PF14783.6 ETO19380.1 - 0.064 13.3 1.7 30 4.7 0.0 4.2 2 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Gmad1 PF10647.9 ETO19380.1 - 0.11 12.3 0.0 2.1 8.0 0.0 2.6 1 1 2 3 3 3 0 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.9 ETO19380.1 - 2.6 7.8 10.7 13 5.5 0.0 5.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Dsh_C PF12316.8 ETO19381.1 - 2.1 8.7 11.0 3.8 7.9 11.0 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF913 PF06025.12 ETO19381.1 - 5.3 5.9 7.3 6.8 5.6 7.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO19381.1 - 6.3 5.5 13.0 6.5 5.4 13.0 1.1 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 ETO19381.1 - 9.2 4.9 11.3 10 4.8 11.3 1.0 1 0 0 1 1 1 0 Raftlin DUF4834 PF16118.5 ETO19382.1 - 2.3 9.2 12.6 0.18 12.8 3.7 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ctr PF04145.15 ETO19382.1 - 7.1 7.2 7.8 13 6.4 0.3 2.7 2 1 0 2 2 2 0 Ctr copper transporter family PK_C PF02887.16 ETO19383.1 - 1.2e-12 48.1 0.5 2.7e-12 46.9 0.5 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain DUF4154 PF13689.6 ETO19383.1 - 0.0062 16.8 0.1 0.02 15.1 0.0 1.9 2 0 0 2 2 2 1 YfiR/HmsC-like YcaO_C PF18381.1 ETO19383.1 - 0.079 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 YcaO cyclodehydratase C-terminal domain DUF1387 PF07139.11 ETO19384.1 - 4.6 6.9 30.0 5.8 6.6 30.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) betaPIX_CC PF16523.5 ETO19385.1 - 0.017 15.0 10.2 0.6 10.0 1.1 2.5 2 0 0 2 2 2 0 betaPIX coiled coil GatB_Yqey PF02637.18 ETO19385.1 - 0.2 11.5 9.6 0.27 11.1 4.5 2.2 2 0 0 2 2 2 0 GatB domain Dict-STAT-coil PF09267.10 ETO19385.1 - 8.7 6.8 16.8 1.9 8.9 0.2 2.9 2 1 0 3 3 3 0 Dictyostelium STAT, coiled coil DUF3439 PF11921.8 ETO19387.1 - 0.1 12.5 7.3 2.4 8.2 7.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) SOBP PF15279.6 ETO19387.1 - 4 8.0 23.6 6.2 7.3 23.6 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein OAD_gamma PF04277.13 ETO19388.1 - 0.29 11.8 4.6 0.36 11.4 4.6 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain SR-25 PF10500.9 ETO19388.1 - 0.97 9.0 22.9 1.1 8.8 22.9 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Sec62 PF03839.16 ETO19388.1 - 1.4 8.3 7.1 1.4 8.4 7.1 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 DUF1387 PF07139.11 ETO19388.1 - 6.7 6.3 15.7 8.4 6.0 15.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) XK-related PF09815.9 ETO19389.1 - 8.9e-07 28.3 10.4 1.8e-06 27.3 10.4 1.4 1 1 0 1 1 1 1 XK-related protein Ank_4 PF13637.6 ETO19391.1 - 1e-16 61.0 0.5 0.00026 21.5 0.1 4.2 2 1 3 5 5 5 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO19391.1 - 5.2e-15 55.8 3.1 3.4e-06 27.6 0.1 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ETO19391.1 - 2.5e-12 46.6 0.1 0.032 14.7 0.0 5.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_3 PF13606.6 ETO19391.1 - 1.7e-11 43.2 0.2 0.44 11.3 0.0 6.0 7 0 0 7 7 7 3 Ankyrin repeat Ank_5 PF13857.6 ETO19391.1 - 9.8e-07 28.9 3.5 0.039 14.3 0.2 4.1 2 1 2 4 4 4 2 Ankyrin repeats (many copies) 3-PAP PF12578.8 ETO19391.1 - 0.022 14.5 0.0 0.05 13.3 0.0 1.6 1 0 0 1 1 1 0 Myotubularin-associated protein AA_permease PF00324.21 ETO19392.1 - 5.9e-23 81.2 9.3 3.8e-19 68.6 9.6 2.0 2 0 0 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 ETO19392.1 - 1.2e-11 44.1 9.0 1.6e-11 43.7 9.0 1.1 1 0 0 1 1 1 1 Amino acid permease Parvo_NS1 PF01057.17 ETO19392.1 - 0.11 11.5 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 FtsX PF02687.21 ETO19392.1 - 4.3 7.9 8.6 3.4 8.2 2.7 2.3 2 0 0 2 2 2 0 FtsX-like permease family SLC12 PF03522.15 ETO19393.1 - 9.5e-45 153.4 3.9 1.1e-18 67.6 0.1 3.7 2 1 1 3 3 3 3 Solute carrier family 12 APO_RNA-bind PF05634.11 ETO19393.1 - 0.14 11.5 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 APO RNA-binding Codanin-1_C PF15296.6 ETO19395.1 - 0.0089 16.1 0.0 0.068 13.2 0.0 2.6 1 0 0 1 1 1 1 Codanin-1 C-terminus Hid1 PF12722.7 ETO19395.1 - 0.013 13.6 11.9 0.023 12.9 11.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein AMP-binding PF00501.28 ETO19396.1 - 5.5e-14 51.6 3.7 9.7e-11 40.9 3.7 2.1 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO19396.1 - 2.4e-08 34.8 0.5 5.2e-08 33.7 0.5 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF3613 PF12266.8 ETO19396.1 - 0.16 11.8 0.1 0.48 10.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3613) TUTF7_u4 PF16631.5 ETO19396.1 - 0.24 12.1 2.7 0.42 11.3 2.7 1.3 1 0 0 1 1 1 0 Unstructured region 4 on terminal uridylyltransferase 7 Tn7_Tnp_TnsA_C PF08721.11 ETO19397.1 - 0.12 13.0 1.2 0.2 12.3 0.2 1.8 2 0 0 2 2 2 0 TnsA endonuclease C terminal Pfk_N PF18468.1 ETO19398.1 - 0.003 18.0 0.2 0.21 12.0 0.0 2.2 1 1 1 2 2 2 2 Phosphofructokinase N-terminal domain yeast Jag_N PF14804.6 ETO19398.1 - 0.19 12.1 1.4 0.42 11.0 1.4 1.5 1 0 0 1 1 1 0 Jag N-terminus LtuB PF17455.2 ETO19401.1 - 0.043 14.4 0.9 0.073 13.7 0.3 1.7 2 0 0 2 2 2 0 Late transcription unit B Cytadhesin_P30 PF07271.11 ETO19404.1 - 0.078 12.5 0.1 0.079 12.5 0.1 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 EF-hand_6 PF13405.6 ETO19406.1 - 0.047 13.6 0.5 7.7 6.7 0.0 2.8 3 1 0 3 3 3 0 EF-hand domain PP_kinase_C PF13090.6 ETO19407.1 - 0.024 14.1 0.2 0.039 13.4 0.2 1.2 1 0 0 1 1 1 0 Polyphosphate kinase C-terminal domain 2 G-patch PF01585.23 ETO19409.1 - 9.4e-10 38.2 0.3 1.5e-09 37.5 0.3 1.4 1 0 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ETO19409.1 - 0.018 15.2 0.1 0.047 13.8 0.1 1.7 1 0 0 1 1 1 0 G-patch domain Acyl_transf_3 PF01757.22 ETO19410.1 - 0.0001 21.5 6.5 0.0001 21.5 6.5 2.1 2 0 0 2 2 2 1 Acyltransferase family DUF4175 PF13779.6 ETO19410.1 - 0.042 11.8 0.0 0.055 11.4 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) BRCT_2 PF16589.5 ETO19411.1 - 0.037 14.5 1.4 0.32 11.4 0.9 2.6 1 1 1 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain SelP_N PF04592.14 ETO19411.1 - 0.067 12.6 15.5 0.13 11.6 15.5 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region JmjC PF02373.22 ETO19413.1 - 5.5e-30 104.1 0.2 9.9e-30 103.3 0.2 1.4 1 0 0 1 1 1 1 JmjC domain, hydroxylase Orf78 PF06024.12 ETO19414.1 - 0.12 12.7 0.0 0.27 11.6 0.0 1.6 2 0 0 2 2 2 0 Orf78 (ac78) DUF4505 PF14956.6 ETO19415.1 - 1.1e-31 109.9 1.4 2.2e-17 63.4 0.0 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4505) WD40 PF00400.32 ETO19416.1 - 1.3e-41 139.7 22.7 2.8e-07 31.1 0.7 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19416.1 - 7.5e-10 39.0 2.9 0.044 14.1 0.0 5.8 3 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19416.1 - 1.7e-09 36.9 5.8 0.0065 15.2 0.1 5.0 2 2 2 4 4 4 4 Nucleoporin Nup120/160 Ricin_B_lectin PF00652.22 ETO19416.1 - 0.11 12.7 6.1 5.4 7.3 0.4 3.5 1 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain Gal_Lectin PF02140.18 ETO19417.1 - 1.6e-05 25.2 0.7 1.6e-05 25.2 0.7 1.9 2 0 0 2 2 2 1 Galactose binding lectin domain CLASP_N PF12348.8 ETO19417.1 - 0.11 12.1 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 CLASP N terminal Ion_trans_2 PF07885.16 ETO19418.1 - 3.9e-06 26.7 6.9 3.9e-06 26.7 6.9 2.8 2 1 0 2 2 2 1 Ion channel Acetyltransf_1 PF00583.25 ETO19421.1 - 0.1 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family Dicty_REP PF05086.12 ETO19422.1 - 0.14 10.1 7.6 0.14 10.1 7.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 ETO19422.1 - 0.38 10.7 10.3 0.47 10.4 10.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein NADH_dehy_S2_C PF06444.11 ETO19422.1 - 0.55 10.8 2.8 14 6.3 0.2 2.2 2 0 0 2 2 2 0 NADH dehydrogenase subunit 2 C-terminus Sec62 PF03839.16 ETO19422.1 - 1.2 8.6 4.1 1.4 8.4 4.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 ubiquitin PF00240.23 ETO19425.1 - 0.065 13.0 0.2 0.32 10.8 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin family RBD PF02196.15 ETO19425.1 - 0.068 13.2 0.0 0.93 9.6 0.0 2.9 3 0 0 3 3 3 0 Raf-like Ras-binding domain ERM PF00769.19 ETO19426.1 - 0.0064 16.3 22.7 0.0076 16.1 22.7 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family SOBP PF15279.6 ETO19426.1 - 1.8 9.1 9.2 2.4 8.7 9.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Ribosomal_60s PF00428.19 ETO19426.1 - 6.1 7.5 14.5 0.44 11.2 5.1 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein ADIP PF11559.8 ETO19428.1 - 0.00012 22.2 7.8 0.00012 22.2 7.8 3.6 2 1 2 4 4 3 1 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 ETO19428.1 - 0.00018 21.6 33.5 0.0023 17.9 5.1 3.7 1 1 2 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 ETO19428.1 - 0.00021 21.0 35.5 0.0025 17.4 5.9 2.8 1 1 1 2 2 2 1 Intermediate filament protein Spc7 PF08317.11 ETO19428.1 - 0.00035 19.5 4.1 0.00035 19.5 4.1 3.0 1 1 0 2 2 2 1 Spc7 kinetochore protein CENP-H PF05837.12 ETO19428.1 - 0.00047 20.5 5.1 0.00047 20.5 5.1 4.3 1 1 2 3 3 3 1 Centromere protein H (CENP-H) EzrA PF06160.12 ETO19428.1 - 0.00066 18.0 29.3 0.0011 17.2 5.0 2.5 1 1 1 2 2 2 2 Septation ring formation regulator, EzrA DUF3584 PF12128.8 ETO19428.1 - 0.0073 13.9 31.4 0.013 13.0 31.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) FAM184 PF15665.5 ETO19428.1 - 0.0074 16.1 12.1 0.0074 16.1 12.1 2.9 2 1 1 3 3 2 1 Family with sequence similarity 184, A and B TPR_MLP1_2 PF07926.12 ETO19428.1 - 0.0077 16.3 37.2 0.1 12.7 12.3 4.1 1 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein AAA_13 PF13166.6 ETO19428.1 - 0.0089 14.7 1.6 0.0089 14.7 1.6 2.3 1 1 1 2 2 2 1 AAA domain PspA_IM30 PF04012.12 ETO19428.1 - 0.011 15.4 27.5 0.11 12.0 9.9 2.8 1 1 1 2 2 2 0 PspA/IM30 family ATG16 PF08614.11 ETO19428.1 - 0.012 15.8 4.2 0.012 15.8 4.2 4.1 2 1 1 3 3 2 0 Autophagy protein 16 (ATG16) GAS PF13851.6 ETO19428.1 - 0.013 14.9 35.5 0.45 9.8 17.2 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Tup_N PF08581.10 ETO19428.1 - 0.014 15.7 31.0 0.11 12.8 2.6 4.2 3 1 0 4 4 3 0 Tup N-terminal CAP PF00188.26 ETO19428.1 - 0.017 16.0 2.3 0.017 16.0 2.3 2.4 3 0 0 3 3 2 0 Cysteine-rich secretory protein family HMMR_N PF15905.5 ETO19428.1 - 0.018 14.6 35.2 0.023 14.2 22.9 3.4 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal HAP1_N PF04849.13 ETO19428.1 - 0.031 13.5 0.5 0.031 13.5 0.5 3.3 1 1 2 3 3 3 0 HAP1 N-terminal conserved region Forkhead_N PF08430.12 ETO19428.1 - 0.034 14.8 22.7 0.082 13.5 22.7 1.7 1 0 0 1 1 1 0 Forkhead N-terminal region DUF1664 PF07889.12 ETO19428.1 - 0.045 13.8 23.7 0.26 11.3 0.2 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) Baculo_PEP_C PF04513.12 ETO19428.1 - 0.046 13.8 13.7 1.8 8.6 2.2 3.5 1 1 2 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DinB_2 PF12867.7 ETO19428.1 - 0.071 13.6 0.4 0.49 10.9 0.4 2.3 1 1 0 1 1 1 0 DinB superfamily BicD PF09730.9 ETO19428.1 - 0.11 10.9 29.9 0.012 14.1 4.2 2.4 1 1 1 2 2 2 0 Microtubule-associated protein Bicaudal-D Atg14 PF10186.9 ETO19428.1 - 0.19 10.8 27.9 0.069 12.2 9.0 2.3 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 PKcGMP_CC PF16808.5 ETO19428.1 - 0.2 11.5 6.8 9.3 6.2 1.5 4.3 3 1 0 3 3 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CALCOCO1 PF07888.11 ETO19428.1 - 0.21 10.4 32.3 0.3 9.9 24.4 2.3 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like TMF_TATA_bd PF12325.8 ETO19428.1 - 0.27 11.4 31.9 0.11 12.7 6.0 3.9 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding ChaC PF04752.12 ETO19428.1 - 0.28 11.2 1.5 0.62 10.1 1.5 1.6 1 0 0 1 1 1 0 ChaC-like protein DUF4407 PF14362.6 ETO19428.1 - 0.31 10.3 28.7 0.16 11.3 11.7 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Fez1 PF06818.15 ETO19428.1 - 0.58 10.6 37.2 0.026 15.0 10.9 2.9 1 1 1 2 2 2 0 Fez1 FUSC PF04632.12 ETO19428.1 - 0.83 8.1 9.5 0.73 8.3 8.2 1.4 1 1 0 1 1 1 0 Fusaric acid resistance protein family GreA_GreB_N PF03449.15 ETO19428.1 - 0.99 9.6 21.3 2.2 8.5 4.2 5.0 3 2 1 4 4 4 0 Transcription elongation factor, N-terminal Tropomyosin PF00261.20 ETO19428.1 - 1.1 8.5 32.3 2.9 7.2 32.3 1.9 1 1 0 1 1 1 0 Tropomyosin APG6_N PF17675.1 ETO19428.1 - 1.2 9.7 37.8 0.095 13.2 14.1 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4686 PF15742.5 ETO19428.1 - 1.3 8.1 37.8 5 6.1 19.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4686) Rab5-bind PF09311.11 ETO19428.1 - 1.5 8.1 36.4 0.039 13.4 13.4 3.1 2 1 1 3 3 2 0 Rabaptin-like protein KELK PF15796.5 ETO19428.1 - 1.5 9.3 33.5 2.6 8.6 1.5 4.8 3 2 0 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase NPV_P10 PF05531.12 ETO19428.1 - 1.8 9.0 16.9 36 4.9 2.1 4.7 2 2 2 4 4 4 0 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 ETO19428.1 - 2.3 8.7 36.4 4.7 7.7 7.5 4.6 1 1 2 3 3 2 0 Cell division protein ZapB DUF1640 PF07798.11 ETO19428.1 - 2.4 8.2 30.6 0.32 11.0 7.6 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) Syntaxin-6_N PF09177.11 ETO19428.1 - 3.6 8.2 20.5 5.1 7.7 2.2 4.0 1 1 2 3 3 3 0 Syntaxin 6, N-terminal FlaC_arch PF05377.11 ETO19428.1 - 3.6 8.0 20.9 27 5.3 0.0 5.7 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) DUF4201 PF13870.6 ETO19428.1 - 3.9 7.2 32.0 0.051 13.3 4.5 3.6 1 1 3 4 4 4 0 Domain of unknown function (DUF4201) Lectin_N PF03954.14 ETO19428.1 - 4.3 7.1 13.2 0.24 11.1 1.1 3.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain TSC22 PF01166.18 ETO19428.1 - 5.2 7.5 18.6 1.7 9.0 0.7 4.8 4 1 1 5 5 5 0 TSC-22/dip/bun family DHR10 PF18595.1 ETO19428.1 - 5.6 7.1 38.6 1.5 8.9 12.9 3.3 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain MCC-bdg_PDZ PF10506.9 ETO19428.1 - 6.3 6.9 15.8 0.15 12.1 6.8 2.8 3 0 0 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome CAF-1_p150 PF11600.8 ETO19428.1 - 6.7 6.4 24.7 50 3.6 21.2 2.8 1 1 1 2 2 2 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal SHE3 PF17078.5 ETO19428.1 - 7.1 6.3 37.2 0.37 10.5 10.2 3.6 2 1 1 3 3 2 0 SWI5-dependent HO expression protein 3 Tho2 PF11262.8 ETO19428.1 - 8 5.6 26.7 2.3 7.4 7.3 2.7 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 HalX PF08663.10 ETO19428.1 - 8.3 6.8 14.7 10 6.5 4.0 4.6 2 1 2 4 4 4 0 HalX domain Exonuc_VII_L PF02601.15 ETO19428.1 - 9 5.8 29.7 0.63 9.6 12.6 2.5 1 1 1 2 2 2 0 Exonuclease VII, large subunit DUF465 PF04325.13 ETO19428.1 - 9.7 6.3 12.8 4.2 7.5 1.5 3.7 3 1 0 3 3 3 0 Protein of unknown function (DUF465) PRKG1_interact PF15898.5 ETO19429.1 - 0.058 14.3 2.8 0.058 14.3 2.8 2.3 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DUF3972 PF13118.6 ETO19429.1 - 0.065 13.7 0.9 0.065 13.7 0.9 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) zf-C2H2 PF00096.26 ETO19432.1 - 2.7e-14 52.7 67.4 0.0003 21.1 3.3 7.4 8 0 0 8 8 7 5 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO19432.1 - 3.2e-13 49.4 59.9 5.7e-05 23.4 4.8 8.0 7 0 0 7 7 7 6 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO19432.1 - 1.9e-12 46.9 52.6 0.00026 21.6 2.1 6.9 6 0 0 6 6 6 5 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETO19432.1 - 2.3e-06 27.7 52.4 0.024 14.9 1.3 7.6 7 0 0 7 7 7 4 Zinc-finger double-stranded RNA-binding OmpH PF03938.14 ETO19432.1 - 0.011 16.0 3.2 0.021 15.1 3.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Vif PF00559.17 ETO19432.1 - 0.014 15.1 0.3 0.027 14.2 0.3 1.5 1 0 0 1 1 1 0 Retroviral Vif (Viral infectivity) protein Bap31_Bap29_C PF18035.1 ETO19432.1 - 0.016 15.2 4.3 0.044 13.8 4.3 1.8 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain zf-C2H2_6 PF13912.6 ETO19432.1 - 0.024 14.6 48.5 0.083 12.9 2.6 6.0 6 0 0 6 6 6 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ETO19432.1 - 0.031 14.6 1.2 0.031 14.6 1.2 6.0 2 2 5 7 7 7 0 C2H2 type zinc-finger (2 copies) zf_UBZ PF18439.1 ETO19432.1 - 0.034 13.8 22.0 5.9 6.6 1.6 5.7 5 0 0 5 5 5 0 Ubiquitin-Binding Zinc Finger DUF4407 PF14362.6 ETO19432.1 - 0.1 11.9 0.5 0.15 11.4 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-met PF12874.7 ETO19432.1 - 0.18 12.3 0.1 0.18 12.3 0.1 7.4 7 1 0 7 7 6 0 Zinc-finger of C2H2 type Tup_N PF08581.10 ETO19432.1 - 0.22 11.8 7.1 0.083 13.2 2.0 2.3 1 1 1 2 2 2 0 Tup N-terminal DUF4337 PF14235.6 ETO19432.1 - 0.93 9.6 3.8 2.2 8.4 3.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) zinc_ribbon_4 PF13717.6 ETO19432.1 - 2.5 8.1 28.3 0.71 9.9 5.8 5.0 4 1 0 4 4 4 0 zinc-ribbon domain Tmemb_cc2 PF10267.9 ETO19432.1 - 9.7 5.2 12.5 0.09 11.9 4.1 1.8 3 0 0 3 3 3 0 Predicted transmembrane and coiled-coil 2 protein Secretin_N_2 PF07655.13 ETO19434.1 - 0.66 10.6 19.3 1.4 9.5 19.3 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain TFIIA PF03153.13 ETO19436.1 - 7e-14 52.6 6.5 7.9e-14 52.5 6.5 1.0 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2358 PF10184.9 ETO19436.1 - 0.013 15.7 0.1 0.018 15.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2358) Membr_traf_MHD PF10540.9 ETO19439.1 - 0.12 12.5 3.0 0.078 13.1 0.5 1.8 2 0 0 2 2 2 0 Munc13 (mammalian uncoordinated) homology domain Amino_oxidase PF01593.24 ETO19440.1 - 2e-18 67.0 0.3 5.9e-17 62.1 0.0 2.3 2 0 0 2 2 2 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETO19440.1 - 5e-12 45.9 0.1 9.8e-12 44.9 0.1 1.5 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain SWIRM PF04433.17 ETO19440.1 - 7.9e-12 45.4 0.2 1.7e-11 44.3 0.2 1.7 1 1 0 1 1 1 1 SWIRM domain FAD_binding_2 PF00890.24 ETO19440.1 - 1.6e-06 27.5 0.6 2.8e-06 26.7 0.6 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ETO19440.1 - 5.6e-05 22.0 0.4 5.6e-05 22.0 0.4 1.7 2 0 0 2 2 1 1 HI0933-like protein Pyr_redox_2 PF07992.14 ETO19440.1 - 8.5e-05 21.9 0.0 8.5e-05 21.9 0.0 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETO19440.1 - 0.0002 20.7 0.0 0.0002 20.7 0.0 1.7 2 0 0 2 2 2 1 Thi4 family DAO PF01266.24 ETO19440.1 - 0.0007 19.3 0.2 0.0007 19.3 0.2 1.8 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETO19440.1 - 0.0012 18.2 0.5 0.0012 18.2 0.5 1.6 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase AlaDh_PNT_C PF01262.21 ETO19440.1 - 0.0014 17.9 0.1 0.0025 17.2 0.1 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_oxidored PF12831.7 ETO19440.1 - 0.0019 17.6 0.6 0.0019 17.6 0.6 2.1 2 0 0 2 2 2 1 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ETO19440.1 - 0.0022 17.3 0.1 0.0022 17.3 0.1 1.6 2 0 0 2 2 2 1 FAD binding domain Pyr_redox PF00070.27 ETO19440.1 - 0.0047 17.5 0.3 0.01 16.4 0.3 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETO19440.1 - 0.013 14.7 0.3 0.013 14.7 0.3 2.1 2 1 1 3 3 2 0 Glucose inhibited division protein A TrkA_N PF02254.18 ETO19440.1 - 0.027 14.7 0.1 0.048 13.9 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain Lycopene_cycl PF05834.12 ETO19440.1 - 0.044 12.8 0.1 0.064 12.3 0.1 1.2 1 0 0 1 1 1 0 Lycopene cyclase protein 2-Hacid_dh_C PF02826.19 ETO19440.1 - 0.087 12.2 0.1 0.19 11.1 0.1 1.5 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CDC27 PF09507.10 ETO19440.1 - 0.49 9.7 35.3 0.62 9.4 35.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Ndc1_Nup PF09531.10 ETO19440.1 - 2.7 6.6 5.5 3.1 6.4 5.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PDCD9 PF07147.12 ETO19441.1 - 0.012 14.9 3.9 0.016 14.4 3.9 1.1 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S30 (PDCD9) Paramyxo_ncap PF00973.19 ETO19441.1 - 0.041 12.8 0.6 0.052 12.5 0.6 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein MMPL PF03176.15 ETO19442.1 - 1.8e-22 79.7 1.4 3.1e-22 79.0 1.4 1.2 1 0 0 1 1 1 1 MMPL family DUF1700 PF08006.11 ETO19442.1 - 0.05 13.1 0.3 0.11 12.0 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Phage_holin_2_4 PF16082.5 ETO19442.1 - 0.2 11.4 0.2 0.48 10.2 0.2 1.7 1 1 0 1 1 1 0 Bacteriophage holin family, superfamily II-like Glyco_transf_49 PF13896.6 ETO19444.1 - 1e-18 67.8 1.2 2e-18 66.8 1.2 1.4 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Peptidase_C6 PF00851.18 ETO19444.1 - 0.069 12.1 0.3 0.11 11.4 0.3 1.3 1 1 0 1 1 1 0 Helper component proteinase DUF641 PF04859.12 ETO19446.1 - 0.0047 17.3 3.5 0.0047 17.3 3.5 3.2 2 1 1 3 3 3 1 Plant protein of unknown function (DUF641) KLRAQ PF10205.9 ETO19446.1 - 0.0069 16.6 11.2 0.0069 16.6 11.2 3.9 3 1 1 4 4 4 1 Predicted coiled-coil domain-containing protein Macoilin PF09726.9 ETO19446.1 - 0.98 7.9 45.8 1.4 7.4 45.8 1.2 1 0 0 1 1 1 0 Macoilin family Tmemb_cc2 PF10267.9 ETO19446.1 - 3.2 6.8 44.9 1.4 8.0 40.9 2.3 1 1 1 2 2 2 0 Predicted transmembrane and coiled-coil 2 protein SCAB-Ig PF16709.5 ETO19447.1 - 0.028 14.4 0.2 0.33 11.0 0.0 2.6 2 0 0 2 2 2 0 Ig domain of plant-specific actin-binding protein muHD PF10291.9 ETO19448.1 - 5.2e-07 29.4 0.0 7.3e-07 28.9 0.0 1.1 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain PCSK9_C2 PF18464.1 ETO19448.1 - 0.12 12.4 1.0 2.4 8.3 0.0 2.3 1 1 1 2 2 2 0 Proprotein convertase subtilisin-like/kexin type 9 C-terminal domain DIOX_N PF14226.6 ETO19450.1 - 8.5e-09 36.2 0.5 2.9e-08 34.5 0.5 1.7 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal EF-hand_1 PF00036.32 ETO19451.1 - 3.7e-05 23.0 0.5 7e-05 22.1 0.5 1.5 1 0 0 1 1 1 1 EF hand EF-hand_8 PF13833.6 ETO19451.1 - 0.00037 20.3 0.1 0.00063 19.5 0.1 1.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO19451.1 - 0.0028 17.4 0.2 0.0075 16.1 0.2 1.7 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETO19451.1 - 0.0066 16.9 0.1 0.014 15.8 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_10 PF14788.6 ETO19451.1 - 0.025 14.4 0.6 0.06 13.2 0.6 1.6 1 0 0 1 1 1 0 EF hand DUF4760 PF15956.5 ETO19453.1 - 0.057 13.6 4.0 2.2 8.4 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4760) FadA PF09403.10 ETO19453.1 - 1 9.9 12.2 1.1 9.8 0.9 3.0 3 0 0 3 3 3 0 Adhesion protein FadA CAP_GLY PF01302.25 ETO19455.1 - 4.8e-26 90.6 5.5 1.6e-12 47.3 0.1 2.5 2 0 0 2 2 2 2 CAP-Gly domain dCMP_cyt_deam_1 PF00383.23 ETO19456.1 - 0.042 13.7 0.1 0.16 11.9 0.1 2.0 1 1 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DNA_pol_B_thumb PF14791.6 ETO19457.1 - 2.9e-22 78.6 0.0 1.5e-21 76.4 0.0 1.9 2 0 0 2 2 2 1 DNA polymerase beta thumb DNA_pol_B_palm PF14792.6 ETO19457.1 - 2.3e-07 31.0 0.0 6.5e-07 29.5 0.0 1.8 1 1 0 1 1 1 1 DNA polymerase beta palm DUF1387 PF07139.11 ETO19458.1 - 0.86 9.3 19.4 1.5 8.5 17.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1387) DUF5364 PF17322.2 ETO19458.1 - 4.7 7.5 23.8 0.27 11.6 11.3 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5364) DUF445 PF04286.12 ETO19458.1 - 6 6.6 16.0 10 5.8 16.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF445) RGS PF00615.19 ETO19459.1 - 0.00021 21.5 1.7 0.00026 21.3 0.9 1.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain UPF0565 PF10561.9 ETO19459.1 - 0.00064 19.0 0.3 0.00077 18.8 0.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0565 Apocytochr_F_C PF01333.19 ETO19459.1 - 0.038 14.0 0.0 0.071 13.1 0.0 1.4 1 0 0 1 1 1 0 Apocytochrome F, C-terminal Snf7 PF03357.21 ETO19460.1 - 5.6e-06 26.1 22.6 0.00012 21.8 8.8 2.1 2 0 0 2 2 2 2 Snf7 Inhibitor_I69 PF13734.6 ETO19461.1 - 0.69 10.4 0.0 0.69 10.4 0.0 2.7 2 1 0 2 2 2 0 Spi protease inhibitor Glyco_transf_10 PF00852.19 ETO19462.1 - 2.8e-33 115.1 0.2 7.1e-33 113.8 0.2 1.7 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term IBR PF01485.21 ETO19463.1 - 6.1e-06 26.4 8.6 6.1e-06 26.4 8.6 5.7 5 1 1 6 6 6 3 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ETO19463.1 - 8.3e-05 22.4 6.0 8.3e-05 22.4 6.0 4.7 5 0 0 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO19463.1 - 0.00038 20.4 0.5 0.00038 20.4 0.5 3.8 3 1 1 4 4 4 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO19463.1 - 0.0046 17.2 9.1 0.0046 17.2 9.1 5.2 5 0 0 5 5 5 1 Ring finger domain CPSF100_C PF13299.6 ETO19463.1 - 4.2 7.5 13.5 13 5.9 7.8 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Afi1 PF07792.12 ETO19464.1 - 0.054 14.0 8.4 0.97 9.9 0.3 2.9 2 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking LPD11 PF18824.1 ETO19464.1 - 0.094 12.8 0.6 0.36 10.9 0.2 2.3 2 0 0 2 2 2 0 Large polyvalent protein-associated domain 11 Iso_dh PF00180.20 ETO19465.1 - 5e-37 127.8 0.0 6.1e-37 127.6 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 ETO19466.1 - 3.5e-11 42.9 0.0 2.1e-10 40.3 0.0 1.8 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase WD40 PF00400.32 ETO19468.1 - 5.7e-05 23.8 1.2 0.0002 22.1 0.4 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Orf78 PF06024.12 ETO19468.1 - 0.55 10.6 8.3 0.96 9.8 0.0 2.5 2 1 0 2 2 2 0 Orf78 (ac78) AMPKBI PF04739.15 ETO19468.1 - 5.2 7.4 7.1 0.51 10.7 0.2 2.8 2 2 0 2 2 2 0 5'-AMP-activated protein kinase beta subunit, interaction domain AIF_C PF14721.6 ETO19468.1 - 9 6.7 7.2 6.9 7.0 0.2 2.3 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term PH_12 PF16457.5 ETO19469.1 - 2.8e-11 44.1 0.7 9.8e-10 39.1 0.0 2.4 1 1 1 2 2 2 1 Pleckstrin homology domain PH_14 PF17787.1 ETO19469.1 - 0.0031 17.4 0.1 0.01 15.7 0.1 1.7 1 1 0 1 1 1 1 PH domain ZFYVE21_C PF16696.5 ETO19469.1 - 0.029 14.3 0.1 0.29 11.0 0.0 2.6 2 1 1 3 3 3 0 Zinc finger FYVE domain-containing protein 21 C-terminus SSP160 PF06933.11 ETO19470.1 - 0.061 11.5 8.4 0.059 11.6 8.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 AP_endonuc_2 PF01261.24 ETO19470.1 - 0.071 12.5 0.1 0.1 12.0 0.1 1.2 1 0 0 1 1 1 0 Xylose isomerase-like TIM barrel DUF3439 PF11921.8 ETO19470.1 - 0.11 12.5 5.9 0.2 11.6 5.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4634 PF15465.6 ETO19470.1 - 0.16 12.3 2.0 0.28 11.5 2.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4634) FSA_C PF10479.9 ETO19470.1 - 0.63 8.1 12.6 0.76 7.8 12.6 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF5592 PF17332.2 ETO19471.1 - 0.93 10.1 5.6 2.6 8.6 5.4 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5592) UPF0242 PF06785.11 ETO19471.1 - 1.9 8.6 4.4 0.3 11.2 0.7 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4337 PF14235.6 ETO19472.1 - 0.0003 20.9 0.8 0.00047 20.3 0.2 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4337) ATG16 PF08614.11 ETO19472.1 - 0.00046 20.5 6.3 0.23 11.7 1.3 2.3 2 0 0 2 2 2 2 Autophagy protein 16 (ATG16) DUF1411 PF07199.11 ETO19472.1 - 0.05 13.3 0.1 0.082 12.6 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1411) PKcGMP_CC PF16808.5 ETO19472.1 - 0.16 11.8 5.5 0.5 10.3 5.5 1.9 1 0 0 1 1 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Val_tRNA-synt_C PF10458.9 ETO19472.1 - 2.9 8.2 6.6 29 5.0 0.2 3.2 3 1 0 3 3 3 0 Valyl tRNA synthetase tRNA binding arm RasGAP PF00616.19 ETO19474.1 - 1.9e-23 83.3 6.8 2.5e-23 82.9 6.8 1.1 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase Pkinase PF00069.25 ETO19475.1 - 1.2e-60 205.1 0.7 1.6e-34 119.5 0.4 2.0 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19475.1 - 3e-25 89.0 0.7 2.1e-20 73.1 0.3 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO19475.1 - 6.7e-06 25.6 0.4 1.7e-05 24.3 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO19475.1 - 0.00021 20.7 0.2 0.26 10.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ETO19475.1 - 0.00048 19.0 0.0 0.00069 18.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO19475.1 - 0.013 15.5 0.0 0.02 14.8 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Alkyl_sulf_dimr PF14863.6 ETO19477.1 - 1.1e-30 106.9 0.0 6.6e-30 104.4 0.0 2.1 1 1 0 1 1 1 1 Alkyl sulfatase dimerisation Lactamase_B PF00753.27 ETO19477.1 - 3e-16 60.0 0.1 3.8e-10 40.1 0.1 2.3 2 0 0 2 2 2 2 Metallo-beta-lactamase superfamily Alkyl_sulf_C PF14864.6 ETO19477.1 - 1.8e-05 25.0 0.2 0.0031 17.8 0.0 2.4 2 0 0 2 2 2 2 Alkyl sulfatase C-terminal Lactamase_B_2 PF12706.7 ETO19477.1 - 0.00046 19.7 0.2 0.00098 18.7 0.2 1.5 1 0 0 1 1 1 1 Beta-lactamase superfamily domain DUF2326 PF10088.9 ETO19481.1 - 0.028 14.1 0.5 0.075 12.8 0.1 1.8 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2326) dCMP_cyt_deam_1 PF00383.23 ETO19483.1 - 1.4e-07 31.3 8.8 3.6e-07 30.0 8.8 1.7 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETO19483.1 - 9.7e-07 28.6 0.7 0.0004 20.2 0.0 2.4 2 0 0 2 2 2 2 MafB19-like deaminase DUF5024 PF16427.5 ETO19483.1 - 0.01 16.1 0.0 0.02 15.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5024) RasGEF PF00617.19 ETO19484.1 - 1.1e-19 71.3 1.3 1.1e-19 71.3 1.3 2.2 2 0 0 2 2 2 1 RasGEF domain zf-RING_7 PF02591.15 ETO19484.1 - 0.0029 17.8 0.0 0.0083 16.3 0.0 1.8 1 0 0 1 1 1 1 C4-type zinc ribbon domain Dicty_REP PF05086.12 ETO19485.1 - 7.4e-05 20.9 1.9 8.9e-05 20.7 1.9 1.0 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein RRM_5 PF13893.6 ETO19485.1 - 0.15 11.7 0.0 0.24 11.0 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4805 PF16063.5 ETO19485.1 - 0.68 9.2 5.3 0.8 9.0 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) PfkB PF00294.24 ETO19486.1 - 9.5e-08 31.7 0.0 1.3e-07 31.2 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase SOG2 PF10428.9 ETO19489.1 - 1.4 8.0 13.2 1.6 7.8 13.2 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Nop14 PF04147.12 ETO19489.1 - 4 5.5 40.6 5 5.2 40.6 1.1 1 0 0 1 1 1 0 Nop14-like family PIG-S PF10510.9 ETO19489.1 - 6.6 5.4 10.4 8.2 5.1 10.4 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein Menin PF05053.13 ETO19489.1 - 8.3 4.6 29.1 10 4.3 29.1 1.1 1 0 0 1 1 1 0 Menin Pkinase PF00069.25 ETO19490.1 - 2.7e-20 72.8 0.0 4.8e-20 72.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19490.1 - 2.9e-10 39.9 0.0 4.4e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO19490.1 - 0.0065 15.8 0.0 0.012 15.0 0.0 1.4 1 0 0 1 1 1 1 Kinase-like SMN PF06003.12 ETO19491.1 - 0.92 8.7 5.8 0.62 9.3 3.4 1.8 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) FMO-like PF00743.19 ETO19492.1 - 5.2e-14 51.6 0.1 6.4e-14 51.3 0.1 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 ETO19492.1 - 2.8e-07 30.7 0.0 4.1e-07 30.1 0.0 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Pyr_redox_3 PF13738.6 ETO19492.1 - 1.6e-05 24.4 0.0 2.3e-05 23.8 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO19492.1 - 0.00053 19.3 0.0 0.00072 18.9 0.0 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO19492.1 - 0.00087 19.8 0.0 0.0052 17.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETO19492.1 - 0.0048 16.9 0.0 0.0062 16.5 0.0 1.3 1 0 0 1 1 1 1 FAD-NAD(P)-binding Thi4 PF01946.17 ETO19492.1 - 0.03 13.6 0.0 0.069 12.4 0.0 1.5 2 0 0 2 2 2 0 Thi4 family DAO PF01266.24 ETO19492.1 - 0.033 13.8 0.0 0.037 13.6 0.0 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ETO19492.1 - 0.046 13.0 0.0 2.8 7.1 0.0 2.1 1 1 1 2 2 2 0 Flavin containing amine oxidoreductase Fungal_KA1 PF16797.5 ETO19492.1 - 0.09 12.5 0.3 0.22 11.2 0.3 1.6 1 0 0 1 1 1 0 Fungal kinase associated-1 domain HI0933_like PF03486.14 ETO19492.1 - 0.11 11.2 0.0 0.14 10.8 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein ThiF PF00899.21 ETO19492.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.3 1 0 0 1 1 1 0 ThiF family Shikimate_DH PF01488.20 ETO19492.1 - 0.14 12.2 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase AcetylCoA_hyd_C PF13336.6 ETO19494.1 - 2.1e-62 209.6 0.0 6.2e-62 208.1 0.0 1.7 2 0 0 2 2 2 1 Acetyl-CoA hydrolase/transferase C-terminal domain AcetylCoA_hydro PF02550.15 ETO19494.1 - 0.00025 21.1 0.1 0.25 11.3 0.0 2.3 2 0 0 2 2 2 2 Acetyl-CoA hydrolase/transferase N-terminal domain Metallophos_2 PF12850.7 ETO19495.1 - 0.054 13.7 0.0 0.063 13.5 0.0 1.1 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain FTH PF01827.27 ETO19496.1 - 0.031 14.1 0.3 0.045 13.6 0.3 1.3 1 0 0 1 1 1 0 FTH domain Ank_4 PF13637.6 ETO19499.1 - 5.2e-20 71.5 0.5 3.1e-08 34.0 0.0 2.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO19499.1 - 1.2e-19 70.7 0.1 6.3e-15 55.5 0.0 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO19499.1 - 1.8e-14 53.6 0.1 4.7e-08 33.1 0.0 3.2 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO19499.1 - 2.3e-14 52.0 0.7 0.044 14.3 0.0 4.5 5 0 0 5 5 5 4 Ankyrin repeat Ank PF00023.30 ETO19499.1 - 2.2e-12 46.8 1.0 0.00068 20.0 0.0 4.3 4 1 0 4 4 4 4 Ankyrin repeat COMPASS-Shg1 PF05205.12 ETO19499.1 - 0.009 16.7 1.0 0.015 16.0 0.2 1.7 2 1 0 2 2 2 1 COMPASS (Complex proteins associated with Set1p) component shg1 DUF1708 PF08101.11 ETO19500.1 - 0.14 11.3 0.2 0.15 11.2 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1708) Glyco_hydro_38N PF01074.22 ETO19503.1 - 4.7e-37 127.9 0.4 6.9e-37 127.4 0.4 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Alpha-mann_mid PF09261.11 ETO19503.1 - 4.6e-17 62.0 0.1 1.1e-16 60.8 0.1 1.6 1 0 0 1 1 1 1 Alpha mannosidase middle domain Asp_protease PF09668.10 ETO19505.1 - 8.7e-21 74.0 0.1 1.4e-20 73.3 0.1 1.3 1 0 0 1 1 1 1 Aspartyl protease ubiquitin PF00240.23 ETO19505.1 - 4e-09 36.1 0.2 4e-09 36.1 0.2 2.2 2 1 0 2 2 2 1 Ubiquitin family gag-asp_proteas PF13975.6 ETO19505.1 - 2.5e-06 27.9 0.0 6.1e-06 26.7 0.0 1.7 1 0 0 1 1 1 1 gag-polyprotein putative aspartyl protease Asp_protease_2 PF13650.6 ETO19505.1 - 0.00023 21.7 0.0 0.00061 20.4 0.0 1.8 1 0 0 1 1 1 1 Aspartyl protease Rad60-SLD PF11976.8 ETO19505.1 - 0.0017 18.2 1.5 0.0029 17.4 0.0 2.1 2 1 0 2 2 2 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETO19505.1 - 0.057 13.5 1.2 4.4 7.4 0.2 3.0 2 1 0 2 2 2 0 Ubiquitin-like domain TetR_C_36 PF18598.1 ETO19505.1 - 0.12 12.3 0.7 0.22 11.5 0.7 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain RXT2_N PF08595.11 ETO19506.1 - 0.013 15.5 6.0 0.02 14.9 6.0 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 ETO19506.1 - 0.047 13.4 1.7 0.089 12.5 1.7 1.4 1 0 0 1 1 1 0 FAM176 family HNOBA PF07701.14 ETO19506.1 - 0.066 12.6 0.1 0.065 12.6 0.1 1.2 1 0 0 1 1 1 0 Heme NO binding associated Pox_Ag35 PF03286.14 ETO19506.1 - 0.14 12.0 6.0 0.22 11.3 6.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RNase_H2_suC PF08615.11 ETO19506.1 - 0.19 11.9 4.4 0.3 11.3 4.3 1.5 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) NOA36 PF06524.12 ETO19506.1 - 0.43 9.8 7.1 0.66 9.2 7.1 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO19506.1 - 0.43 11.0 6.5 1 9.8 6.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PBP1_TM PF14812.6 ETO19506.1 - 0.59 10.5 12.5 0.42 11.0 7.8 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF1168 PF06658.12 ETO19506.1 - 1.4 8.7 13.2 2.7 7.8 13.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DNA_pol_phi PF04931.13 ETO19506.1 - 9.1 4.2 8.0 13 3.8 8.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Methyltransf_28 PF02636.17 ETO19507.1 - 0.041 13.5 1.3 0.075 12.7 0.1 1.9 2 1 0 2 2 2 0 Putative S-adenosyl-L-methionine-dependent methyltransferase ALO PF04030.14 ETO19508.1 - 3.8e-16 59.7 0.2 3.3e-07 30.4 0.0 2.2 2 0 0 2 2 2 2 D-arabinono-1,4-lactone oxidase FAD_binding_4 PF01565.23 ETO19508.1 - 1.1e-10 41.4 0.3 2e-10 40.5 0.3 1.5 1 0 0 1 1 1 1 FAD binding domain ADH_zinc_N PF00107.26 ETO19509.1 - 4.3e-19 68.8 0.3 7.2e-19 68.0 0.3 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO19509.1 - 1.6e-08 34.4 2.6 2.4e-08 33.8 2.1 1.6 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 ETO19509.1 - 0.041 13.3 0.0 0.053 12.9 0.0 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Sin3_corepress PF08295.12 ETO19511.1 - 6.3e-21 74.3 0.0 1.8e-20 72.8 0.0 1.8 1 0 0 1 1 1 1 Sin3 family co-repressor S1 PF00575.23 ETO19512.1 - 0.00073 19.8 0.5 0.0041 17.4 0.5 2.0 1 1 0 1 1 1 1 S1 RNA binding domain Bromodomain PF00439.25 ETO19513.1 - 2e-08 34.2 0.0 4.9e-08 32.9 0.0 1.7 1 0 0 1 1 1 1 Bromodomain CCDC53 PF10152.9 ETO19513.1 - 0.014 15.8 8.5 0.014 15.8 8.5 2.0 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex BUD22 PF09073.10 ETO19513.1 - 0.026 13.9 16.7 0.036 13.4 16.7 1.2 1 0 0 1 1 1 0 BUD22 DUF5523 PF17661.1 ETO19513.1 - 0.028 14.1 16.2 0.06 13.0 16.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5523) DUF2428 PF10350.9 ETO19513.1 - 0.068 12.4 2.8 0.1 11.8 2.8 1.3 1 0 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) NOA36 PF06524.12 ETO19513.1 - 0.14 11.4 12.6 0.29 10.4 12.6 1.5 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 ETO19513.1 - 0.22 10.9 16.2 0.55 9.6 16.2 1.8 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PI3K_1B_p101 PF10486.9 ETO19513.1 - 0.23 9.2 5.2 0.27 9.0 5.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4746 PF15928.5 ETO19513.1 - 0.27 10.6 23.5 0.81 9.1 17.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) RPN2_C PF18004.1 ETO19513.1 - 0.36 10.8 13.1 0.78 9.6 13.1 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain GNAT_acetyltr_2 PF13718.6 ETO19513.1 - 0.51 9.7 9.9 0.26 10.7 7.4 1.8 1 1 0 1 1 1 0 GNAT acetyltransferase 2 DNA_pol_phi PF04931.13 ETO19513.1 - 0.57 8.2 20.4 0.78 7.8 20.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4407 PF14362.6 ETO19513.1 - 0.91 8.8 6.8 1.3 8.3 6.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RNA_pol_Rpc4 PF05132.14 ETO19513.1 - 1.2 9.5 7.2 2.5 8.5 7.2 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 ETO19513.1 - 1.2 8.2 10.8 2.4 7.3 10.8 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit TMEM119 PF15724.5 ETO19513.1 - 2.3 8.2 8.7 3.6 7.6 8.7 1.2 1 0 0 1 1 1 0 TMEM119 family EIIBC-GUT_N PF03612.14 ETO19513.1 - 2.3 7.9 6.3 5.1 6.8 6.3 1.6 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SelP_N PF04592.14 ETO19513.1 - 2.4 7.5 28.1 0.44 9.9 14.4 2.4 2 0 0 2 2 2 0 Selenoprotein P, N terminal region Connexin PF00029.19 ETO19513.1 - 3.7 7.2 9.3 0.45 10.2 4.2 1.9 2 0 0 2 2 2 0 Connexin Serinc PF03348.15 ETO19513.1 - 4.5 6.1 7.1 6.2 5.6 7.1 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Velvet PF11754.8 ETO19513.1 - 6.6 6.6 6.6 5.7 6.8 1.2 2.1 2 0 0 2 2 2 0 Velvet factor DUF4820 PF16091.5 ETO19513.1 - 6.6 6.0 11.0 12 5.1 11.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) GOLD_2 PF13897.6 ETO19513.1 - 10 6.7 16.7 12 6.4 13.8 2.3 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking Pkinase_Tyr PF07714.17 ETO19514.1 - 9.8e-46 156.1 0.0 1.2e-45 155.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO19514.1 - 8.3e-41 140.1 0.0 1.2e-40 139.6 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO19514.1 - 0.00039 19.3 0.1 0.00055 18.8 0.1 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO19514.1 - 0.071 12.4 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Kinase-like BHD_2 PF10404.9 ETO19516.1 - 0.018 16.0 0.4 0.024 15.6 0.4 1.2 1 0 0 1 1 1 0 Rad4 beta-hairpin domain 2 Ribosomal_60s PF00428.19 ETO19516.1 - 1.6 9.4 8.7 2.2 8.9 8.7 1.2 1 0 0 1 1 1 0 60s Acidic ribosomal protein 3Beta_HSD PF01073.19 ETO19517.1 - 1e-12 47.6 0.0 1.3e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO19517.1 - 3.6e-12 46.3 0.0 4.9e-12 45.8 0.0 1.3 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ETO19517.1 - 3.4e-11 43.4 0.0 4.7e-11 42.9 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ETO19517.1 - 1.3e-09 38.0 0.0 1.6e-09 37.7 0.0 1.1 1 0 0 1 1 1 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ETO19517.1 - 2.3e-09 37.1 0.0 3e-09 36.7 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase adh_short PF00106.25 ETO19517.1 - 1.3e-06 28.0 0.0 1.8e-06 27.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO19517.1 - 3.7e-05 23.7 0.0 5.1e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ETO19517.1 - 0.0049 16.5 0.0 0.0064 16.1 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase NAD_binding_4 PF07993.12 ETO19517.1 - 0.009 15.2 0.0 0.024 13.8 0.0 1.7 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 ETO19517.1 - 0.014 14.5 0.0 0.02 14.0 0.0 1.1 1 0 0 1 1 1 0 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ETO19517.1 - 0.029 13.5 0.0 0.038 13.1 0.0 1.1 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF2193 PF09959.9 ETO19517.1 - 0.032 12.7 0.0 0.037 12.5 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) CAP_GLY PF01302.25 ETO19518.1 - 2.3e-12 46.7 0.3 4.7e-12 45.8 0.3 1.5 1 0 0 1 1 1 1 CAP-Gly domain 7tm_1 PF00001.21 ETO19518.1 - 0.028 13.8 0.0 0.063 12.6 0.0 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) XRN_M PF17846.1 ETO19519.1 - 4.9e-62 210.3 1.0 5.8e-62 210.1 1.0 1.1 1 0 0 1 1 1 1 Xrn1 helical domain Vhr1 PF04001.13 ETO19519.1 - 0.059 13.7 1.8 0.34 11.2 0.3 2.2 2 0 0 2 2 2 0 Transcription factor Vhr1 RGS PF00615.19 ETO19520.1 - 3.5e-06 27.3 0.4 8.5e-06 26.0 0.2 1.7 2 1 0 2 2 2 1 Regulator of G protein signaling domain L27_2 PF09045.10 ETO19520.1 - 0.027 14.4 0.6 0.69 9.9 0.2 2.9 3 0 0 3 3 3 0 L27_2 NMD3 PF04981.13 ETO19521.1 - 6.4e-36 124.0 1.4 6.4e-36 124.0 1.4 1.9 2 0 0 2 2 2 1 NMD3 family GAS PF13851.6 ETO19522.1 - 2.3e-06 27.1 46.2 0.00069 19.0 7.1 3.5 1 1 2 3 3 3 3 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ETO19522.1 - 3.4e-06 27.1 49.4 0.00087 19.3 16.7 3.5 1 1 3 4 4 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FPP PF05911.11 ETO19522.1 - 1.6e-05 23.4 46.0 0.0003 19.1 21.7 2.0 1 1 1 2 2 2 2 Filament-like plant protein, long coiled-coil SlyX PF04102.12 ETO19522.1 - 7.7e-05 23.2 35.1 0.0065 17.1 4.4 4.9 1 1 4 5 5 5 2 SlyX FlaC_arch PF05377.11 ETO19522.1 - 8.2e-05 22.9 27.5 0.2 12.1 2.0 5.3 2 2 2 5 5 5 3 Flagella accessory protein C (FlaC) Rootletin PF15035.6 ETO19522.1 - 0.00011 22.3 19.7 0.00011 22.3 19.7 3.1 1 1 2 3 3 3 1 Ciliary rootlet component, centrosome cohesion Spc7 PF08317.11 ETO19522.1 - 0.00029 19.9 44.9 0.028 13.3 17.4 2.3 1 1 1 2 2 2 2 Spc7 kinetochore protein DUF1192 PF06698.11 ETO19522.1 - 0.00045 20.2 8.3 0.0029 17.6 1.4 3.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1192) Fez1 PF06818.15 ETO19522.1 - 0.00047 20.7 42.4 0.085 13.3 23.4 2.4 1 1 1 2 2 2 2 Fez1 UPF0242 PF06785.11 ETO19522.1 - 0.00054 20.1 44.4 0.086 12.9 19.0 2.3 1 1 1 2 2 2 2 Uncharacterised protein family (UPF0242) N-terminus DUF641 PF04859.12 ETO19522.1 - 0.00059 20.2 37.0 0.097 13.0 4.1 4.3 1 1 3 4 4 4 2 Plant protein of unknown function (DUF641) KASH_CCD PF14662.6 ETO19522.1 - 0.001 19.0 49.6 0.0013 18.6 30.5 3.1 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH HrpB7 PF09486.10 ETO19522.1 - 0.0011 19.4 25.1 0.026 14.9 9.8 3.7 1 1 2 3 3 3 1 Bacterial type III secretion protein (HrpB7) Csm1_N PF18504.1 ETO19522.1 - 0.0011 19.2 40.1 0.21 11.9 4.8 5.7 1 1 3 5 5 5 3 Csm1 N-terminal domain DUF4201 PF13870.6 ETO19522.1 - 0.0013 18.5 39.3 0.011 15.4 14.2 3.2 1 1 2 3 3 3 1 Domain of unknown function (DUF4201) Lebercilin PF15619.6 ETO19522.1 - 0.0019 17.9 26.7 0.0019 17.9 26.7 3.1 1 1 2 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease Baculo_PEP_C PF04513.12 ETO19522.1 - 0.0022 18.0 15.8 0.13 12.3 3.2 2.5 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus PspA_IM30 PF04012.12 ETO19522.1 - 0.0032 17.1 42.6 0.15 11.6 20.2 3.7 1 1 2 3 3 3 2 PspA/IM30 family APG6_N PF17675.1 ETO19522.1 - 0.0033 17.9 18.3 0.0033 17.9 18.3 3.2 1 1 2 3 3 3 1 Apg6 coiled-coil region TACC_C PF05010.14 ETO19522.1 - 0.0039 17.0 40.3 0.026 14.3 31.8 2.4 1 1 1 2 2 2 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal TolA_bind_tri PF16331.5 ETO19522.1 - 0.0041 17.2 40.2 0.07 13.2 8.9 4.4 1 1 3 4 4 4 2 TolA binding protein trimerisation Filament PF00038.21 ETO19522.1 - 0.0044 16.6 39.1 0.009 15.6 39.1 1.5 1 1 0 1 1 1 1 Intermediate filament protein HMMR_N PF15905.5 ETO19522.1 - 0.0053 16.3 44.2 0.012 15.2 44.2 1.5 1 1 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal Mod_r PF07200.13 ETO19522.1 - 0.0076 16.4 16.9 0.0076 16.4 16.9 2.9 1 1 2 3 3 3 1 Modifier of rudimentary (Mod(r)) protein MAD PF05557.13 ETO19522.1 - 0.0078 14.6 44.8 0.013 13.9 44.8 1.4 1 1 0 1 1 1 1 Mitotic checkpoint protein TMF_TATA_bd PF12325.8 ETO19522.1 - 0.0089 16.2 42.8 0.028 14.7 10.3 3.9 1 1 2 3 3 3 2 TATA element modulatory factor 1 TATA binding PRKG1_interact PF15898.5 ETO19522.1 - 0.0092 16.9 12.6 0.0092 16.9 12.6 3.8 1 1 3 4 4 4 2 cGMP-dependent protein kinase interacting domain Atg14 PF10186.9 ETO19522.1 - 0.0097 15.0 40.1 0.055 12.5 18.6 2.6 1 1 1 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 HOOK PF05622.12 ETO19522.1 - 0.0098 14.1 42.4 0.032 12.4 25.9 2.0 1 1 1 2 2 2 2 HOOK protein DUF2968 PF11180.8 ETO19522.1 - 0.011 15.4 9.4 0.011 15.4 9.4 3.2 1 1 1 3 3 3 0 Protein of unknown function (DUF2968) CASP_C PF08172.12 ETO19522.1 - 0.014 14.8 29.4 0.021 14.2 21.9 3.2 1 1 1 2 2 2 0 CASP C terminal DUF1664 PF07889.12 ETO19522.1 - 0.017 15.2 26.0 1.4 8.9 7.7 3.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) MscS_porin PF12795.7 ETO19522.1 - 0.018 14.6 43.5 1.1 8.8 32.6 3.1 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain Prefoldin_2 PF01920.20 ETO19522.1 - 0.018 15.0 42.9 0.66 10.0 2.5 5.5 2 2 3 5 5 5 0 Prefoldin subunit GIT_CC PF16559.5 ETO19522.1 - 0.021 14.7 0.8 0.021 14.7 0.8 5.0 2 2 3 5 5 5 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF4795 PF16043.5 ETO19522.1 - 0.021 14.4 39.8 0.042 13.4 10.0 4.0 1 1 3 4 4 4 0 Domain of unknown function (DUF4795) ATG16 PF08614.11 ETO19522.1 - 0.021 15.0 48.0 0.39 10.9 30.6 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 ETO19522.1 - 0.023 15.1 3.6 0.023 15.1 3.6 4.9 1 1 2 4 4 4 0 Cell division protein ZapB SHE3 PF17078.5 ETO19522.1 - 0.025 14.3 38.2 0.077 12.7 35.6 2.6 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 Tup_N PF08581.10 ETO19522.1 - 0.025 14.9 4.3 0.025 14.9 4.3 4.2 1 1 3 4 4 4 0 Tup N-terminal ADIP PF11559.8 ETO19522.1 - 0.03 14.4 46.5 0.2 11.8 16.8 3.7 1 1 1 2 2 1 0 Afadin- and alpha -actinin-Binding APG17 PF04108.12 ETO19522.1 - 0.031 13.4 24.7 0.4 9.8 7.5 2.2 1 1 1 2 2 2 0 Autophagy protein Apg17 DUF4407 PF14362.6 ETO19522.1 - 0.032 13.6 29.3 0.6 9.4 11.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Spc24 PF08286.11 ETO19522.1 - 0.033 14.4 41.3 0.19 12.0 2.3 5.0 1 1 3 4 4 3 0 Spc24 subunit of Ndc80 Jnk-SapK_ap_N PF09744.9 ETO19522.1 - 0.034 14.4 47.2 0.13 12.5 18.7 2.6 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 XhlA PF10779.9 ETO19522.1 - 0.035 14.3 28.9 0.13 12.4 3.2 4.4 1 1 4 5 5 5 0 Haemolysin XhlA DUF5595 PF18077.1 ETO19522.1 - 0.036 14.1 1.2 0.036 14.1 1.2 4.5 3 2 1 4 4 4 0 Domain of unknown function (DUF5595) NPV_P10 PF05531.12 ETO19522.1 - 0.037 14.5 18.0 0.31 11.6 2.0 4.0 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 ETO19522.1 - 0.051 13.9 32.1 1.4 9.3 3.3 4.2 1 1 4 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Fib_alpha PF08702.10 ETO19522.1 - 0.057 13.6 31.0 1.1 9.5 10.3 3.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF2730 PF10805.8 ETO19522.1 - 0.059 13.5 28.6 1.5 8.9 3.1 4.2 1 1 3 4 4 4 0 Protein of unknown function (DUF2730) Med9 PF07544.13 ETO19522.1 - 0.09 12.9 33.3 2.2 8.4 11.1 4.8 2 2 2 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 DUF3450 PF11932.8 ETO19522.1 - 0.093 12.0 41.5 0.02 14.2 5.0 4.1 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) DASH_Dam1 PF08653.10 ETO19522.1 - 0.11 12.4 9.7 0.49 10.2 0.1 4.6 2 2 1 3 3 3 0 DASH complex subunit Dam1 DUF4200 PF13863.6 ETO19522.1 - 0.12 12.8 41.3 0.12 12.7 11.0 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4200) DUF4164 PF13747.6 ETO19522.1 - 0.13 12.6 32.0 0.26 11.6 7.0 4.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4164) Prefoldin PF02996.17 ETO19522.1 - 0.17 11.8 33.0 0.39 10.6 1.3 5.2 2 1 3 5 5 5 0 Prefoldin subunit ERM PF00769.19 ETO19522.1 - 0.18 11.6 45.3 0.93 9.3 25.6 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF848 PF05852.11 ETO19522.1 - 0.18 11.9 28.1 2.4 8.3 1.2 3.6 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) FapA PF03961.13 ETO19522.1 - 0.2 10.3 34.9 0.33 9.5 13.3 2.8 1 1 2 3 3 3 0 Flagellar Assembly Protein A DUF5082 PF16888.5 ETO19522.1 - 0.2 11.9 33.8 0.64 10.3 5.9 4.3 1 1 4 5 5 5 0 Domain of unknown function (DUF5082) Bacillus_HBL PF05791.11 ETO19522.1 - 0.21 11.4 24.2 0.071 12.9 8.3 3.7 2 2 2 4 4 4 0 Bacillus haemolytic enterotoxin (HBL) AIP3 PF03915.13 ETO19522.1 - 0.26 10.3 28.8 1.8 7.6 27.9 2.3 1 1 0 1 1 1 0 Actin interacting protein 3 YabA PF06156.13 ETO19522.1 - 0.28 11.8 34.8 2.4 8.8 5.7 4.5 1 1 2 3 3 3 0 Initiation control protein YabA Tropomyosin_1 PF12718.7 ETO19522.1 - 0.32 11.1 48.3 2.7 8.1 23.8 3.8 1 1 3 4 4 4 0 Tropomyosin like DHR10 PF18595.1 ETO19522.1 - 0.42 10.7 53.4 0.15 12.1 14.7 4.4 1 1 2 4 4 4 0 Designed helical repeat protein 10 domain Laminin_II PF06009.12 ETO19522.1 - 0.48 10.5 29.7 0.47 10.5 8.9 3.2 1 1 2 3 3 3 0 Laminin Domain II bZIP_1 PF00170.21 ETO19522.1 - 0.54 10.4 44.6 0.11 12.6 3.8 6.5 2 1 5 7 7 7 0 bZIP transcription factor MbeD_MobD PF04899.12 ETO19522.1 - 0.64 10.2 27.8 0.13 12.4 4.1 4.3 2 1 2 4 4 4 0 MbeD/MobD like HIP1_clath_bdg PF16515.5 ETO19522.1 - 0.76 10.4 50.2 0.29 11.7 12.3 4.7 1 1 5 6 6 6 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF3584 PF12128.8 ETO19522.1 - 0.79 7.2 36.8 2 5.8 36.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) Nup54 PF13874.6 ETO19522.1 - 0.93 9.6 33.4 0.51 10.5 18.8 3.8 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 T3SSipB PF16535.5 ETO19522.1 - 1 9.8 29.3 0.9 10.0 11.5 2.8 1 1 2 3 3 3 0 Type III cell invasion protein SipB Syntaxin-6_N PF09177.11 ETO19522.1 - 1 9.9 30.8 0.11 13.0 9.5 4.3 1 1 2 3 3 3 0 Syntaxin 6, N-terminal CEP63 PF17045.5 ETO19522.1 - 1.1 9.1 46.3 25 4.6 46.3 2.7 1 1 0 1 1 1 0 Centrosomal protein of 63 kDa Rab5-bind PF09311.11 ETO19522.1 - 1.1 8.6 39.4 1.5 8.2 15.9 2.3 1 1 0 2 2 2 0 Rabaptin-like protein CALCOCO1 PF07888.11 ETO19522.1 - 1.1 8.0 42.3 6.4 5.5 5.1 2.7 1 1 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF16 PF01519.16 ETO19522.1 - 1.4 9.5 30.6 2.4 8.7 5.7 4.0 1 1 2 3 3 3 0 Protein of unknown function DUF16 KxDL PF10241.9 ETO19522.1 - 1.4 9.3 31.4 0.53 10.6 4.1 4.3 2 2 3 5 5 5 0 Uncharacterized conserved protein Ax_dynein_light PF10211.9 ETO19522.1 - 1.4 8.8 40.6 0.16 11.9 6.1 4.2 2 1 1 3 3 2 0 Axonemal dynein light chain DUF4988 PF16378.5 ETO19522.1 - 1.5 8.5 13.4 11 5.6 1.7 4.0 2 2 2 4 4 4 0 Domain of unknown function LIF_OSM PF01291.17 ETO19522.1 - 1.5 8.9 14.0 1.8 8.7 3.5 3.2 1 1 1 2 2 2 0 LIF / OSM family DUF745 PF05335.13 ETO19522.1 - 1.7 8.3 32.3 4.7 6.9 12.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF745) EzrA PF06160.12 ETO19522.1 - 1.8 6.6 33.0 2.1 6.4 14.1 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF812 PF05667.11 ETO19522.1 - 1.9 7.2 42.9 5.1 5.9 17.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF812) MCC-bdg_PDZ PF10506.9 ETO19522.1 - 2.1 8.4 31.2 17 5.5 6.7 5.2 1 1 2 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Leu_zip PF15294.6 ETO19522.1 - 2.3 7.6 41.2 0.92 9.0 17.0 2.5 1 1 1 2 2 2 0 Leucine zipper PI3K_P85_iSH2 PF16454.5 ETO19522.1 - 2.4 7.7 35.5 0.31 10.6 12.8 3.5 1 1 1 2 2 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain BRE1 PF08647.11 ETO19522.1 - 2.5 8.2 43.3 0.38 10.9 14.0 3.5 1 1 2 3 3 3 0 BRE1 E3 ubiquitin ligase DUF2333 PF10095.9 ETO19522.1 - 2.6 7.0 10.1 3.8 6.4 10.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2333) DASH_Spc19 PF08287.11 ETO19522.1 - 2.7 7.9 43.8 0.48 10.3 13.2 3.7 1 1 3 4 4 4 0 Spc19 AAA_13 PF13166.6 ETO19522.1 - 2.9 6.4 34.2 0.29 9.7 21.9 2.0 1 1 1 2 2 2 0 AAA domain Exonuc_VII_L PF02601.15 ETO19522.1 - 2.9 7.4 37.0 4.7 6.7 17.2 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit GvpL_GvpF PF06386.11 ETO19522.1 - 3.1 7.7 17.9 0.53 10.2 12.6 2.3 1 1 1 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF OmpH PF03938.14 ETO19522.1 - 3.2 8.1 40.7 14 6.0 4.4 3.6 1 1 2 3 3 3 0 Outer membrane protein (OmpH-like) Uso1_p115_C PF04871.13 ETO19522.1 - 3.2 8.1 45.8 1.2 9.6 15.6 3.4 1 1 2 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region TPR_MLP1_2 PF07926.12 ETO19522.1 - 3.4 7.7 48.1 9.8 6.2 14.0 3.5 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein PI_PP_I PF18363.1 ETO19522.1 - 3.6 7.8 8.6 1.9 8.7 0.4 3.1 1 1 3 4 4 3 0 Phosphoinositide phosphatase insertion domain CLZ PF16526.5 ETO19522.1 - 3.8 7.9 37.9 0.26 11.7 5.2 5.4 1 1 4 5 5 5 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3138 PF11336.8 ETO19522.1 - 4.1 5.9 6.0 1.2 7.7 2.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3138) Swi5 PF07061.11 ETO19522.1 - 4.3 7.5 34.9 5.4 7.2 3.3 5.5 1 1 3 4 4 3 0 Swi5 PEARLI-4 PF05278.12 ETO19522.1 - 4.3 6.9 31.7 0.29 10.7 5.9 3.3 1 1 2 3 3 3 0 Arabidopsis phospholipase-like protein (PEARLI 4) LPP PF04728.13 ETO19522.1 - 4.3 7.8 17.8 7.3 7.1 0.3 4.6 1 1 2 3 3 3 0 Lipoprotein leucine-zipper CREPT PF16566.5 ETO19522.1 - 5.2 7.2 35.2 0.23 11.6 4.7 4.0 1 1 3 4 4 4 0 Cell-cycle alteration and expression-elevated protein in tumour DivIC PF04977.15 ETO19522.1 - 5.6 6.8 38.1 0.18 11.6 3.6 5.7 1 1 5 6 6 6 0 Septum formation initiator bZIP_2 PF07716.15 ETO19522.1 - 6.2 7.0 39.4 0.39 10.8 0.7 7.0 4 2 3 7 7 7 0 Basic region leucine zipper TMPIT PF07851.13 ETO19522.1 - 6.7 5.9 32.3 4.1 6.6 9.5 2.8 1 1 1 2 2 2 0 TMPIT-like protein Troponin PF00992.20 ETO19522.1 - 6.8 7.0 36.6 0.054 13.8 14.6 3.3 1 1 1 2 2 1 0 Troponin YscO-like PF16789.5 ETO19522.1 - 7 6.7 35.7 1.8 8.6 16.7 2.6 1 1 0 2 2 2 0 YscO-like protein DivIVA PF05103.13 ETO19522.1 - 7.6 6.6 37.7 4.7 7.3 13.9 4.0 2 1 2 4 4 3 0 DivIVA protein HAUS-augmin3 PF14932.6 ETO19522.1 - 9.1 5.8 42.4 13 5.3 16.4 2.8 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 UPF0061 PF02696.14 ETO19523.1 - 3.5e-50 171.1 0.0 4.8e-50 170.7 0.0 1.1 1 0 0 1 1 1 1 Uncharacterized ACR, YdiU/UPF0061 family Adaptin_N PF01602.20 ETO19525.1 - 1.9e-55 188.4 3.4 2.4e-55 188.1 3.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Nop14 PF04147.12 ETO19525.1 - 0.035 12.4 16.5 0.049 11.9 16.5 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 ETO19525.1 - 0.067 11.7 4.7 0.1 11.2 4.7 1.4 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CobT PF06213.12 ETO19525.1 - 0.089 12.2 12.3 0.14 11.5 12.3 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nucleo_P87 PF07267.11 ETO19525.1 - 0.11 11.4 8.5 0.15 10.9 8.5 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF913 PF06025.12 ETO19525.1 - 0.11 11.4 3.4 0.18 10.8 3.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) SDA1 PF05285.12 ETO19525.1 - 0.13 11.6 20.5 0.19 11.1 20.5 1.1 1 0 0 1 1 1 0 SDA1 Hydantoinase_A PF01968.18 ETO19525.1 - 0.23 10.7 0.4 0.37 10.0 0.4 1.2 1 0 0 1 1 1 0 Hydantoinase/oxoprolinase Connexin PF00029.19 ETO19525.1 - 0.32 10.7 1.9 0.53 10.0 1.9 1.4 1 0 0 1 1 1 0 Connexin Orf78 PF06024.12 ETO19525.1 - 0.55 10.6 5.4 3.3 8.1 5.4 2.2 1 1 0 1 1 1 0 Orf78 (ac78) SLC12 PF03522.15 ETO19525.1 - 1.4 7.8 8.3 2.1 7.2 8.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 ETO19525.1 - 1.9 8.3 14.2 2.8 7.7 14.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peroxin-3 PF04882.12 ETO19525.1 - 8.4 5.3 9.7 13 4.7 9.7 1.3 1 0 0 1 1 1 0 Peroxin-3 DUF2530 PF10745.9 ETO19526.1 - 0.034 14.4 0.6 0.2 11.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) CLZ PF16526.5 ETO19527.1 - 0.13 12.6 9.3 0.48 10.8 4.5 2.4 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels T2SSM PF04612.12 ETO19527.1 - 0.68 10.0 2.8 0.36 10.9 0.5 1.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M Mto2_bdg PF12808.7 ETO19527.1 - 1.5 9.2 8.0 6.4 7.2 1.8 2.6 2 0 0 2 2 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DUF2347 PF09804.9 ETO19527.1 - 2.7 7.5 12.2 0.44 10.1 3.1 2.0 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2347) MAT1 PF06391.13 ETO19527.1 - 5.8 6.7 26.9 4.2 7.1 9.1 2.1 1 1 1 2 2 2 0 CDK-activating kinase assembly factor MAT1 E1_UFD PF09358.10 ETO19528.1 - 0.03 15.0 1.8 0.27 12.0 1.3 2.8 1 1 0 1 1 1 0 Ubiquitin fold domain Myc_N PF01056.18 ETO19528.1 - 0.23 11.3 6.4 0.14 12.0 4.7 1.5 2 0 0 2 2 2 0 Myc amino-terminal region FtsH_ext PF06480.15 ETO19529.1 - 0.015 15.6 1.9 0.016 15.5 0.6 1.7 2 0 0 2 2 2 0 FtsH Extracellular Babuvirus_MP PF07234.11 ETO19529.1 - 0.27 11.4 1.3 0.5 10.5 1.3 1.4 1 0 0 1 1 1 0 Movement and RNA silencing protein Aldo_ket_red PF00248.21 ETO19530.1 - 3e-51 174.4 0.3 3.5e-51 174.1 0.3 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family RGS PF00615.19 ETO19531.1 - 1.4e-05 25.3 1.3 6.5e-05 23.2 0.1 2.3 2 0 0 2 2 2 1 Regulator of G protein signaling domain DUF3849 PF12960.7 ETO19531.1 - 0.028 14.4 0.0 0.058 13.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3849) YMF19 PF02326.15 ETO19534.1 - 3.8 8.4 13.5 0.16 12.7 3.4 2.9 3 0 0 3 3 3 0 Plant ATP synthase F0 ATP-synt_8 PF00895.20 ETO19535.1 - 1.6 9.3 7.6 13 6.4 0.2 3.2 3 0 0 3 3 3 0 ATP synthase protein 8 UQ_con PF00179.26 ETO19536.1 - 4e-08 33.0 0.0 7.3e-08 32.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Rb_C PF08934.10 ETO19536.1 - 0.06 13.1 0.8 0.11 12.3 0.8 1.4 1 1 0 1 1 1 0 Rb C-terminal domain NYN PF01936.18 ETO19537.1 - 1.7e-06 28.6 0.0 2.1e-06 28.2 0.0 1.1 1 0 0 1 1 1 1 NYN domain U-box PF04564.15 ETO19539.1 - 0.00037 20.6 0.0 0.00092 19.3 0.0 1.7 1 0 0 1 1 1 1 U-box domain Sec62 PF03839.16 ETO19540.1 - 0.99 8.9 3.2 0.91 9.0 0.1 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 FAM176 PF14851.6 ETO19540.1 - 1.6 8.4 8.3 0.27 10.9 1.6 2.4 2 0 0 2 2 2 0 FAM176 family Pox_Ag35 PF03286.14 ETO19540.1 - 3.9 7.2 21.5 0.11 12.2 9.8 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Pkinase PF00069.25 ETO19542.1 - 8.8e-11 41.7 0.2 1.7e-10 40.7 0.2 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO19542.1 - 4.8e-09 35.5 0.0 5.5e-09 35.3 0.0 1.0 1 0 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 ETO19542.1 - 0.002 17.2 0.5 0.0025 16.9 0.2 1.3 1 1 0 1 1 1 1 Poxvirus serine/threonine protein kinase Pkinase_Tyr PF07714.17 ETO19542.1 - 0.0043 16.4 0.3 0.0094 15.3 0.3 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase DUF2714 PF10896.8 ETO19542.1 - 0.014 15.4 0.1 0.016 15.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2714) DUF3899 PF13038.6 ETO19542.1 - 0.13 12.8 1.1 0.2 12.2 1.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3899) PQ-loop PF04193.14 ETO19543.1 - 4.4e-17 61.6 4.0 9.1e-17 60.6 4.0 1.6 1 0 0 1 1 1 1 PQ loop repeat SUR7 PF06687.12 ETO19543.1 - 0.0036 17.0 1.2 0.0062 16.2 1.2 1.3 1 0 0 1 1 1 1 SUR7/PalI family FlgH PF02107.16 ETO19543.1 - 0.17 11.4 0.1 0.29 10.7 0.1 1.3 1 0 0 1 1 1 0 Flagellar L-ring protein SelP_N PF04592.14 ETO19544.1 - 0.00019 20.9 5.7 0.00029 20.3 5.7 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Presenilin PF01080.17 ETO19544.1 - 0.0015 17.4 0.7 0.0025 16.6 0.7 1.5 1 0 0 1 1 1 1 Presenilin NPR3 PF03666.13 ETO19544.1 - 0.0022 16.8 0.0 0.0022 16.8 0.0 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF2370 PF10176.9 ETO19544.1 - 0.0028 17.3 0.6 0.0044 16.7 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2370) FAM60A PF15396.6 ETO19544.1 - 0.003 17.6 1.7 0.0055 16.7 1.7 1.4 1 0 0 1 1 1 1 Protein Family FAM60A DUF3405 PF11885.8 ETO19544.1 - 0.0032 16.2 1.2 0.0041 15.8 1.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) EPL1 PF10513.9 ETO19544.1 - 0.0046 17.3 2.6 0.0059 17.0 2.6 1.2 1 0 0 1 1 1 1 Enhancer of polycomb-like CSG2 PF16965.5 ETO19544.1 - 0.0054 15.7 0.5 0.0078 15.2 0.5 1.3 1 0 0 1 1 1 1 Ceramide synthase regulator V_ATPase_I PF01496.19 ETO19544.1 - 0.0062 14.5 0.9 0.0078 14.2 0.9 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Neur_chan_memb PF02932.16 ETO19544.1 - 0.0067 16.5 0.1 0.0091 16.1 0.1 1.3 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Med3 PF11593.8 ETO19544.1 - 0.0078 15.5 14.6 0.01 15.1 14.6 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Pex14_N PF04695.13 ETO19544.1 - 0.0081 16.8 2.9 0.0081 16.8 2.9 1.9 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region TraG_N PF07916.11 ETO19544.1 - 0.027 13.3 0.4 0.036 12.9 0.4 1.2 1 0 0 1 1 1 0 TraG-like protein, N-terminal region Gti1_Pac2 PF09729.9 ETO19544.1 - 0.033 14.3 2.8 0.05 13.7 2.8 1.2 1 0 0 1 1 1 0 Gti1/Pac2 family Roughex PF06020.11 ETO19544.1 - 0.061 12.4 4.3 0.084 12.0 4.3 1.1 1 0 0 1 1 1 0 Drosophila roughex protein CPSF100_C PF13299.6 ETO19544.1 - 0.16 12.1 4.7 0.25 11.5 4.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal HORMA PF02301.18 ETO19544.1 - 0.5 9.9 4.4 0.83 9.2 4.4 1.2 1 0 0 1 1 1 0 HORMA domain DUF2371 PF10177.9 ETO19544.1 - 0.98 9.6 6.5 0.32 11.2 2.5 2.1 2 1 0 2 2 1 0 Uncharacterised conserved protein (DUF2371) Menin PF05053.13 ETO19544.1 - 1 7.6 7.2 1.4 7.2 7.2 1.1 1 0 0 1 1 1 0 Menin DUF1754 PF08555.10 ETO19544.1 - 1.5 9.7 8.2 2.2 9.1 8.2 1.2 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Band_3_cyto PF07565.13 ETO19544.1 - 1.6 8.5 8.0 2.4 7.9 8.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain ALMT PF11744.8 ETO19544.1 - 1.7 7.4 7.0 2.4 6.9 7.0 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 ETO19544.1 - 6.4 5.9 18.5 2.9 7.0 12.1 2.3 1 1 1 2 2 2 0 ZIP Zinc transporter DUF202 PF02656.15 ETO19546.1 - 0.041 14.3 0.0 0.073 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF202) PIG-P PF08510.12 ETO19546.1 - 0.073 13.0 0.4 0.18 11.8 0.4 1.7 1 1 0 1 1 1 0 PIG-P Peptidase_U40 PF10464.9 ETO19546.1 - 0.12 12.1 0.0 0.19 11.4 0.0 1.3 1 0 0 1 1 1 0 Peptidase U40 Arf PF00025.21 ETO19547.1 - 9.3e-30 103.4 0.0 1e-29 103.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETO19547.1 - 1.9e-07 30.6 0.3 2.1e-06 27.2 0.3 2.0 1 1 0 1 1 1 1 G-protein alpha subunit Roc PF08477.13 ETO19547.1 - 2.4e-07 31.0 0.0 3.7e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO19547.1 - 4.2e-07 29.7 0.0 4.6e-07 29.6 0.0 1.1 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 ETO19547.1 - 0.0017 17.9 0.0 0.0021 17.6 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO19547.1 - 0.0046 16.3 0.0 0.0056 16.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO19547.1 - 0.061 13.4 0.0 0.089 12.9 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase F-box_4 PF15966.5 ETO19548.1 - 0.025 14.5 0.2 0.058 13.3 0.1 1.7 2 0 0 2 2 2 0 F-box DUF3514 PF12027.8 ETO19548.1 - 0.026 14.2 1.0 0.029 14.1 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3514) F-box-like PF12937.7 ETO19548.1 - 0.032 14.1 1.0 0.068 13.1 0.5 1.8 2 1 0 2 2 2 0 F-box-like RP-C_C PF11800.8 ETO19548.1 - 0.12 12.4 0.1 0.16 12.1 0.1 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region ParA PF10609.9 ETO19550.1 - 9.4e-07 28.5 0.0 1.3e-06 28.0 0.0 1.3 1 1 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CD36 PF01130.21 ETO19551.1 - 1.6e-10 40.1 0.2 1.9e-08 33.3 0.1 2.0 2 0 0 2 2 2 2 CD36 family SecY PF00344.20 ETO19552.1 - 0.00077 18.8 0.1 0.00097 18.5 0.1 1.2 1 0 0 1 1 1 1 SecY translocase WBP-1 PF11669.8 ETO19552.1 - 0.038 14.6 1.7 0.055 14.1 0.7 1.7 1 1 1 2 2 2 0 WW domain-binding protein 1 Presenilin PF01080.17 ETO19552.1 - 0.55 8.9 5.3 0.61 8.8 5.3 1.3 1 0 0 1 1 1 0 Presenilin CaATP_NAI PF12515.8 ETO19553.1 - 0.17 11.5 2.0 0.19 11.3 0.1 2.0 2 0 0 2 2 2 0 Ca2+-ATPase N terminal autoinhibitory domain SUIM_assoc PF16619.5 ETO19553.1 - 0.47 10.6 4.1 1.4 9.1 4.1 1.8 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 TMA7 PF09072.10 ETO19553.1 - 7.5 7.5 9.2 0.61 11.0 0.7 2.4 2 0 0 2 2 2 0 Translation machinery associated TMA7 N_BRCA1_IG PF16158.5 ETO19554.1 - 1.3e-05 25.9 7.6 2.4e-05 25.0 0.0 2.6 2 1 0 2 2 2 1 Ig-like domain from next to BRCA1 gene EPL1 PF10513.9 ETO19554.1 - 0.00017 22.0 4.6 0.00021 21.7 4.6 1.3 1 0 0 1 1 1 1 Enhancer of polycomb-like DDHD PF02862.17 ETO19554.1 - 0.00018 21.8 1.8 0.00018 21.8 1.8 1.2 1 0 0 1 1 1 1 DDHD domain SpoIIP PF07454.11 ETO19554.1 - 0.0022 17.5 13.9 0.003 17.1 13.9 1.2 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) Sec62 PF03839.16 ETO19554.1 - 0.012 15.2 9.3 0.019 14.5 9.3 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Otopetrin PF03189.13 ETO19554.1 - 0.027 13.3 3.9 0.025 13.4 3.9 1.2 1 0 0 1 1 1 0 Otopetrin ABC2_membrane_2 PF12679.7 ETO19554.1 - 0.044 13.0 0.2 0.051 12.9 0.2 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein CopC PF04234.12 ETO19554.1 - 0.18 12.9 4.8 0.18 12.8 0.0 2.3 2 0 0 2 2 2 0 CopC domain SpoIIIAH PF12685.7 ETO19554.1 - 0.25 11.1 15.4 12 5.6 0.0 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein Dynamin_N PF00350.23 ETO19554.1 - 0.37 10.8 5.9 0.47 10.5 3.9 1.9 2 0 0 2 2 2 0 Dynamin family Spt20 PF12090.8 ETO19554.1 - 0.53 9.9 49.4 0.75 9.4 49.4 1.3 1 0 0 1 1 1 0 Spt20 family TFIIA PF03153.13 ETO19554.1 - 0.73 9.8 40.2 0.97 9.4 40.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Tim54 PF11711.8 ETO19554.1 - 1.2 7.9 15.9 1.4 7.6 15.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 AF-4 PF05110.13 ETO19554.1 - 1.7 6.6 23.2 2.3 6.2 23.2 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TERB2 PF15101.6 ETO19554.1 - 1.9 8.5 24.1 6 6.9 24.8 1.5 2 0 0 2 2 1 0 Telomere-associated protein TERB2 Pex14_N PF04695.13 ETO19554.1 - 4.4 7.9 26.3 6.8 7.3 26.3 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CobT PF06213.12 ETO19554.1 - 5 6.4 23.6 6.7 6.0 23.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MMR1 PF08505.10 ETO19554.1 - 6.9 6.9 20.7 11 6.3 20.7 1.3 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4228 PF14009.6 ETO19554.1 - 7 7.0 9.8 9.7 6.5 9.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) DUF4746 PF15928.5 ETO19554.1 - 7.3 5.9 12.4 9.6 5.5 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PTR2 PF00854.21 ETO19555.1 - 3.1e-20 72.4 0.2 4.3e-20 71.9 0.2 1.2 1 0 0 1 1 1 1 POT family UNC-50 PF05216.13 ETO19555.1 - 0.019 14.5 4.0 0.028 14.0 4.0 1.2 1 0 0 1 1 1 0 UNC-50 family Cation_ATPase_C PF00689.21 ETO19555.1 - 0.026 14.3 0.3 0.035 13.8 0.3 1.2 1 0 0 1 1 1 0 Cation transporting ATPase, C-terminus DUF4752 PF15944.5 ETO19555.1 - 0.028 14.5 2.2 0.053 13.6 2.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) FA_desaturase PF00487.24 ETO19555.1 - 0.053 13.3 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase MscL PF01741.18 ETO19555.1 - 0.43 10.9 1.5 0.44 10.9 0.0 1.8 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Cytochrom_C_asm PF01578.20 ETO19555.1 - 0.63 9.8 4.1 0.72 9.6 1.8 1.9 1 1 1 2 2 2 0 Cytochrome C assembly protein DUF1440 PF07274.12 ETO19555.1 - 8.6 6.7 7.3 4.8 7.5 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1440) His_Phos_1 PF00300.22 ETO19556.1 - 0.014 15.1 0.0 0.017 14.8 0.0 1.1 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) DNA_III_psi PF03603.13 ETO19557.1 - 0.079 13.2 0.0 7.9 6.7 0.0 2.6 2 0 0 2 2 2 0 DNA polymerase III psi subunit Glyco_hyd_65N_2 PF14498.6 ETO19558.1 - 0.068 13.0 0.5 0.087 12.7 0.5 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 65, N-terminal domain Orf78 PF06024.12 ETO19560.1 - 0.22 11.8 4.8 3.8 7.9 2.0 2.3 1 1 1 2 2 2 0 Orf78 (ac78) GWT1 PF06423.12 ETO19560.1 - 0.23 11.6 6.1 0.58 10.3 0.5 2.2 1 1 1 2 2 2 0 GWT1 HDAC4_Gln PF12203.8 ETO19561.1 - 0.043 14.0 2.4 0.043 14.0 2.4 2.5 2 1 0 2 2 2 0 Glutamine rich N terminal domain of histone deacetylase 4 Bap31 PF05529.12 ETO19561.1 - 0.095 12.6 0.2 0.39 10.6 0.0 2.1 2 1 0 2 2 2 0 Bap31/Bap29 transmembrane region TPR_1 PF00515.28 ETO19562.1 - 4.1e-12 45.4 8.5 3.7e-05 23.3 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO19562.1 - 1.6e-11 43.4 11.7 0.00082 19.3 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO19562.1 - 8.7e-11 41.4 0.6 0.00046 20.4 0.4 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19562.1 - 6.4e-09 35.3 1.6 0.022 14.9 0.0 4.1 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO19562.1 - 1.2e-08 34.5 4.1 9.3e-06 25.2 0.3 3.7 1 1 2 3 3 3 2 TPR repeat TPR_12 PF13424.6 ETO19562.1 - 3.7e-06 27.1 4.1 0.0019 18.5 0.4 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO19562.1 - 3.7e-05 24.1 2.7 0.0047 17.4 0.9 3.3 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO19562.1 - 7.4e-05 23.3 0.3 0.015 15.9 0.0 2.8 1 1 3 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO19562.1 - 0.0039 17.4 10.7 0.083 13.1 4.5 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETO19562.1 - 0.0059 16.9 0.1 2.5 8.5 0.0 2.9 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO19562.1 - 0.014 16.2 2.6 23 6.2 0.1 4.1 3 1 1 4 4 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO19562.1 - 0.035 14.2 0.5 2 8.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO19563.1 - 2e-37 126.5 28.1 1.8e-06 28.5 0.3 8.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19563.1 - 2.2e-14 53.5 2.3 0.0034 17.6 0.0 6.7 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO19563.1 - 2.1e-08 33.3 4.3 0.16 10.6 0.1 4.6 1 1 2 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO19563.1 - 4.5e-07 30.5 1.8 1.9e-06 28.5 1.8 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger Fez1 PF06818.15 ETO19563.1 - 0.11 12.9 16.4 0.2 12.1 16.4 1.4 1 0 0 1 1 1 0 Fez1 Csm1_N PF18504.1 ETO19563.1 - 0.35 11.2 13.1 0.16 12.3 5.8 2.8 1 1 1 2 2 2 0 Csm1 N-terminal domain WD40 PF00400.32 ETO19564.1 - 7.8e-59 194.3 9.2 1.5e-10 41.4 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19564.1 - 9.2e-24 83.6 3.4 0.0017 18.6 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO19564.1 - 7.8e-12 45.1 2.8 1.6e-05 24.4 0.2 4.4 3 2 1 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETO19564.1 - 3.9e-11 43.2 0.4 0.0013 18.7 0.1 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO19564.1 - 9.3e-09 34.5 1.1 0.068 11.8 0.0 4.9 3 2 3 6 6 6 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO19564.1 - 1.8e-08 33.7 0.1 0.25 10.3 0.0 4.9 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PQQ PF01011.21 ETO19564.1 - 9.3e-05 22.2 0.0 2.3 8.3 0.0 5.1 6 0 0 6 6 6 1 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETO19564.1 - 0.00011 20.9 0.1 0.1 11.1 0.0 2.7 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO19564.1 - 0.00039 19.3 3.9 1.4 7.6 0.0 4.2 1 1 1 4 4 4 2 Nup133 N terminal like Me-amine-dh_H PF06433.11 ETO19564.1 - 0.011 14.7 0.0 0.58 9.0 0.0 2.8 3 0 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) PALB2_WD40 PF16756.5 ETO19564.1 - 0.023 13.6 2.6 10 4.9 0.0 4.0 2 2 2 5 5 5 0 Partner and localizer of BRCA2 WD40 domain HPS6 PF15702.5 ETO19564.1 - 0.12 10.3 0.0 5.2 4.9 0.0 2.3 1 1 1 2 2 2 0 Hermansky-Pudlak syndrome 6 protein ROS_MUCR PF05443.11 ETO19564.1 - 0.15 12.1 0.1 18 5.4 0.0 2.8 3 0 0 3 3 2 0 ROS/MUCR transcriptional regulator protein DUF1387 PF07139.11 ETO19565.1 - 1.4 8.6 24.5 1.6 8.4 24.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) PAT1 PF09770.9 ETO19565.1 - 5 5.3 13.3 5.3 5.2 13.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ras PF00071.22 ETO19566.1 - 8.2e-38 129.6 0.9 2.3e-18 66.3 0.1 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO19566.1 - 8.9e-30 103.4 0.3 3.7e-16 59.4 0.0 2.2 1 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO19566.1 - 2.2e-08 33.8 1.1 2.3e-06 27.2 1.1 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO19566.1 - 3.4e-06 27.1 0.1 4.7e-06 26.7 0.1 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO19566.1 - 0.0002 20.8 0.3 0.00035 20.0 0.3 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RST PF12174.8 ETO19566.1 - 0.0099 15.8 0.2 0.038 13.9 0.0 2.0 2 0 0 2 2 2 1 RCD1-SRO-TAF4 (RST) plant domain SRPRB PF09439.10 ETO19566.1 - 0.012 15.0 0.3 0.034 13.6 0.3 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit RsgA_GTPase PF03193.16 ETO19566.1 - 0.014 15.3 0.2 0.26 11.2 0.0 2.2 1 1 1 2 2 2 0 RsgA GTPase ATPase_2 PF01637.18 ETO19566.1 - 0.026 14.4 0.2 0.035 14.0 0.2 1.3 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ETO19566.1 - 0.072 13.1 0.5 0.7 9.9 0.5 2.1 1 1 0 1 1 1 0 AAA domain GTP_EFTU PF00009.27 ETO19566.1 - 0.14 11.7 0.3 0.31 10.6 0.3 1.8 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain CCD48 PF15799.5 ETO19567.1 - 0.19 10.0 2.4 0.17 10.2 1.5 1.3 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 48 DUF4666 PF15697.5 ETO19567.1 - 1.4 9.7 5.0 1.9 9.2 4.8 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4666) FAM76 PF16046.5 ETO19567.1 - 4.5 6.5 13.9 5.2 6.3 13.9 1.1 1 0 0 1 1 1 0 FAM76 protein BAF1_ABF1 PF04684.13 ETO19567.1 - 5.1 6.0 29.0 5.7 5.9 29.0 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Lactamase_B PF00753.27 ETO19568.1 - 3.1e-05 24.1 6.4 3.1e-05 24.1 6.4 1.6 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETO19568.1 - 0.0031 17.1 2.1 0.0042 16.6 2.1 1.2 1 0 0 1 1 1 1 Beta-lactamase superfamily domain RGS PF00615.19 ETO19569.1 - 0.12 12.6 1.1 0.18 12.1 0.2 1.7 2 0 0 2 2 2 0 Regulator of G protein signaling domain Pkinase PF00069.25 ETO19570.1 - 2.5e-52 177.8 0.4 9.4e-52 176.0 0.4 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19570.1 - 3e-24 85.7 0.3 1.4e-23 83.6 0.3 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO19570.1 - 5.9e-23 78.7 12.1 3.2e-06 26.3 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO19570.1 - 8.8e-20 70.9 8.6 1.5e-09 38.2 0.1 2.9 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO19570.1 - 1.1e-18 65.8 9.1 5.3e-07 28.8 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO19570.1 - 3.4e-16 57.7 12.3 8e-06 25.4 0.7 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ETO19570.1 - 6.9e-12 45.0 7.1 2.1e-05 24.3 0.5 4.5 3 1 1 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO19570.1 - 1.1e-07 32.2 3.7 0.01 16.2 0.1 3.7 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Kdo PF06293.14 ETO19570.1 - 5.6e-06 25.9 0.1 1.1e-05 24.9 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO19570.1 - 0.0029 17.6 0.0 0.018 15.0 0.1 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO19570.1 - 0.021 14.1 0.1 0.18 11.1 0.0 2.4 1 1 1 2 2 2 0 Kinase-like EF-hand_9 PF14658.6 ETO19570.1 - 0.057 13.8 0.6 5.6 7.4 0.0 3.2 3 0 0 3 3 3 0 EF-hand domain EF-hand_11 PF08976.11 ETO19570.1 - 0.085 13.7 0.1 0.32 11.9 0.1 2.0 1 0 0 1 1 1 0 EF-hand domain EF-hand_4 PF12763.7 ETO19570.1 - 0.17 11.9 8.3 4 7.4 0.2 4.3 2 1 2 4 4 4 0 Cytoskeletal-regulatory complex EF hand PT PF04886.12 ETO19571.1 - 0.00018 21.0 21.3 0.011 15.3 21.3 2.3 1 1 0 1 1 1 1 PT repeat DUF3810 PF12725.7 ETO19571.1 - 0.0015 17.9 2.9 0.0021 17.5 2.3 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3810) Ureide_permease PF07168.11 ETO19571.1 - 0.0071 15.1 3.0 0.01 14.6 3.0 1.2 1 0 0 1 1 1 1 Ureide permease NosD PF05048.13 ETO19571.1 - 8.3 5.6 18.9 0.03 13.6 6.9 2.1 2 0 0 2 2 2 0 Periplasmic copper-binding protein (NosD) DUF4106 PF13388.6 ETO19571.1 - 9.5 5.3 10.6 9.2 5.4 9.2 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4106) G-alpha PF00503.20 ETO19572.1 - 2.3e-28 99.4 0.1 2.7e-28 99.2 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO19572.1 - 1.8e-05 24.3 0.0 2.7e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETO19573.1 - 3.6e-32 111.9 4.1 4.1e-32 111.7 4.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit PUL PF08324.11 ETO19574.1 - 4.5e-23 81.9 1.8 7.7e-23 81.1 1.8 1.4 1 0 0 1 1 1 1 PUL domain Thioredoxin PF00085.20 ETO19574.1 - 1.1e-20 73.5 0.0 2.7e-20 72.3 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin STI1 PF17830.1 ETO19574.1 - 8.4e-06 25.6 8.4 8.4e-06 25.6 8.4 1.9 2 0 0 2 2 2 1 STI1 domain OST3_OST6 PF04756.13 ETO19574.1 - 1.8e-05 24.2 0.0 3.5e-05 23.3 0.0 1.5 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ETO19574.1 - 3.4e-05 24.2 0.0 0.00012 22.5 0.0 2.0 1 0 0 1 1 1 1 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ETO19574.1 - 0.023 14.9 0.0 0.067 13.4 0.0 1.9 1 0 0 1 1 1 0 Thioredoxin-like AhpC-TSA PF00578.21 ETO19574.1 - 0.028 14.3 0.0 0.063 13.2 0.0 1.6 1 0 0 1 1 1 0 AhpC/TSA family Thioredoxin_8 PF13905.6 ETO19574.1 - 0.08 13.3 0.0 0.39 11.1 0.0 2.2 1 0 0 1 1 1 0 Thioredoxin-like zf-CCCH PF00642.24 ETO19575.1 - 1.1e-07 31.6 7.0 0.00038 20.3 0.2 2.9 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ETO19575.1 - 6.3e-06 26.8 3.9 0.0028 18.3 0.2 2.3 2 0 0 2 2 2 2 Torus domain RRM_1 PF00076.22 ETO19575.1 - 2.1e-05 24.3 1.4 0.00024 20.9 1.4 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 ETO19575.1 - 0.00023 21.1 11.5 0.00071 19.5 3.0 3.1 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_4 PF18044.1 ETO19575.1 - 0.00049 19.8 2.2 0.00049 19.8 2.2 2.5 2 0 0 2 2 2 1 CCCH-type zinc finger Nup35_RRM_2 PF14605.6 ETO19575.1 - 0.18 11.9 1.1 0.89 9.6 0.5 2.6 2 1 0 2 2 2 0 Nup53/35/40-type RNA recognition motif CBM_19 PF03427.13 ETO19575.1 - 1.1 9.2 3.9 1 9.4 0.7 2.2 2 0 0 2 2 2 0 Carbohydrate binding domain (family 19) MMPL PF03176.15 ETO19576.1 - 7.3e-29 100.7 5.2 7.3e-29 100.7 5.2 1.7 2 0 0 2 2 2 1 MMPL family Wzy_C PF04932.15 ETO19576.1 - 0.14 11.8 6.8 1.2 8.8 3.0 2.4 2 1 0 2 2 2 0 O-Antigen ligase AAA_11 PF13086.6 ETO19576.1 - 0.17 11.6 0.0 0.23 11.2 0.0 1.1 1 0 0 1 1 1 0 AAA domain XK-related PF09815.9 ETO19577.1 - 3.1e-08 33.1 9.9 1.7e-07 30.6 9.9 2.0 1 1 0 1 1 1 1 XK-related protein DC_STAMP PF07782.13 ETO19577.1 - 1.4 8.7 5.4 0.16 11.8 0.9 1.7 2 0 0 2 2 2 0 DC-STAMP-like protein DUF1204 PF06721.11 ETO19578.1 - 0.84 9.0 5.7 0.77 9.2 4.0 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1204) Glyco_hydro_3_C PF01915.22 ETO19579.1 - 2e-07 31.2 0.1 3.6e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Fn3-like PF14310.6 ETO19579.1 - 0.00037 20.6 0.0 0.00064 19.8 0.0 1.4 1 0 0 1 1 1 1 Fibronectin type III-like domain Big_5 PF13205.6 ETO19579.1 - 0.053 14.2 0.5 0.12 13.1 0.5 1.6 1 1 0 1 1 1 0 Bacterial Ig-like domain PhoD_N PF16655.5 ETO19579.1 - 0.083 13.4 0.0 0.17 12.4 0.0 1.5 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain SwrA PF17423.2 ETO19579.1 - 0.1 12.6 0.0 0.24 11.4 0.0 1.6 1 0 0 1 1 1 0 Swarming motility protein CDP-OH_P_transf PF01066.21 ETO19580.1 - 3.5e-11 43.7 0.7 3.5e-11 43.7 0.7 2.7 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase OTOS PF15182.6 ETO19580.1 - 0.0075 16.2 0.3 0.022 14.6 0.3 1.8 1 0 0 1 1 1 1 Otospiralin TnsD PF15978.5 ETO19580.1 - 0.022 13.8 0.2 0.034 13.2 0.2 1.2 1 0 0 1 1 1 0 Tn7-like transposition protein D RRM_1 PF00076.22 ETO19581.1 - 1.2e-05 25.1 0.0 2.3e-05 24.1 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF5305 PF17231.2 ETO19581.1 - 0.13 11.6 6.6 0.21 10.9 6.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5305) SOBP PF15279.6 ETO19581.1 - 0.65 10.5 16.2 0.78 10.3 16.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein TFIIA PF03153.13 ETO19581.1 - 1.3 8.9 20.4 1.6 8.6 20.4 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Menin PF05053.13 ETO19581.1 - 5.9 5.1 12.6 7.3 4.8 12.6 1.0 1 0 0 1 1 1 0 Menin DUF3439 PF11921.8 ETO19582.1 - 0.17 11.8 4.1 0.28 11.1 4.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FAM199X PF15814.5 ETO19582.1 - 0.59 9.1 6.3 0.73 8.8 6.3 1.1 1 0 0 1 1 1 0 Protein family FAM199X Macoilin PF09726.9 ETO19582.1 - 2.8 6.4 11.5 2.8 6.4 11.5 1.0 1 0 0 1 1 1 0 Macoilin family VWA_2 PF13519.6 ETO19583.1 - 2.1e-16 60.5 0.2 3.6e-16 59.7 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO19583.1 - 1.2e-14 54.9 0.2 2e-14 54.2 0.2 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO19583.1 - 9.9e-06 25.6 0.0 1.8e-05 24.7 0.0 1.5 1 1 0 1 1 1 1 von Willebrand factor type A domain Flavodoxin_NdrI PF07972.11 ETO19583.1 - 0.02 15.1 0.0 5.2 7.3 0.0 2.4 2 0 0 2 2 2 0 NrdI Flavodoxin like CTP_transf_like PF01467.26 ETO19585.1 - 4.9e-26 91.6 0.5 3.1e-16 59.8 0.2 3.3 2 2 0 2 2 2 2 Cytidylyltransferase-like PIH1 PF08190.12 ETO19587.1 - 4.2e-17 62.1 5.1 2.2e-08 33.8 0.0 4.0 3 1 0 3 3 3 2 PIH1 N-terminal domain CS PF04969.16 ETO19587.1 - 4.8e-05 24.3 0.4 4.8e-05 24.3 0.4 3.4 2 1 1 3 3 3 1 CS domain Connexin PF00029.19 ETO19587.1 - 4.2 7.1 8.8 7.3 6.3 0.1 2.4 1 1 1 2 2 2 0 Connexin WWE PF02825.20 ETO19588.1 - 7.5e-09 36.1 1.1 7.5e-09 36.1 1.1 3.1 3 0 0 3 3 3 1 WWE domain CNH PF00780.22 ETO19589.1 - 1.2e-14 54.6 1.5 1.2e-14 54.6 1.5 3.2 2 1 1 3 3 3 1 CNH domain Clathrin PF00637.20 ETO19589.1 - 2.4e-05 24.2 5.7 2.4e-05 24.2 5.7 3.1 3 1 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.9 ETO19589.1 - 0.001 19.4 18.8 0.0014 18.8 0.5 5.6 4 1 1 5 5 5 1 Vacuolar sorting protein 39 domain 1 Vps39_2 PF10367.9 ETO19589.1 - 0.01 16.3 2.6 0.017 15.6 0.3 2.8 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 Phostensin_N PF13916.6 ETO19589.1 - 1.9 8.9 5.6 0.77 10.1 0.5 2.7 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal zf-RING_2 PF13639.6 ETO19590.1 - 6.5e-13 48.8 6.0 1.1e-12 48.1 6.0 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO19590.1 - 3.5e-08 33.1 2.9 8.1e-08 31.9 2.9 1.7 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO19590.1 - 4.6e-08 32.8 7.5 8.1e-08 32.0 7.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO19590.1 - 5.9e-08 32.9 5.8 1.8e-07 31.3 5.8 1.9 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO19590.1 - 8.5e-06 25.6 6.7 1.6e-05 24.7 6.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO19590.1 - 1.9e-05 24.5 3.1 2.8e-05 23.9 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO19590.1 - 0.00023 21.1 4.7 0.00053 20.0 4.7 1.7 1 0 0 1 1 1 1 RING-type zinc-finger Zn_ribbon_17 PF17120.5 ETO19590.1 - 0.00024 20.6 4.1 0.00041 19.9 4.1 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 ETO19590.1 - 0.0013 18.6 5.1 0.0026 17.7 5.1 1.5 1 0 0 1 1 1 1 zinc-RING finger domain FANCL_C PF11793.8 ETO19590.1 - 0.0024 18.0 6.0 0.011 15.9 6.0 2.1 1 1 0 1 1 1 1 FANCL C-terminal domain zf-ANAPC11 PF12861.7 ETO19590.1 - 0.0032 17.5 1.9 0.0071 16.4 1.9 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING-like PF08746.11 ETO19590.1 - 0.026 14.8 5.0 0.047 14.0 5.0 1.5 1 0 0 1 1 1 0 RING-like domain DUF899 PF05988.12 ETO19590.1 - 0.026 14.0 0.2 0.061 12.9 0.2 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF899) tRNA_anti-like PF12869.7 ETO19590.1 - 0.036 13.7 2.4 1.3 8.6 0.0 2.9 2 1 1 3 3 3 0 tRNA_anti-like Prok-RING_4 PF14447.6 ETO19590.1 - 0.042 13.7 5.9 0.25 11.2 5.3 2.2 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 Endonuclease_7 PF02945.15 ETO19590.1 - 0.046 13.6 1.0 0.1 12.5 1.0 1.6 1 0 0 1 1 1 0 Recombination endonuclease VII zf-RING_10 PF16685.5 ETO19590.1 - 0.051 13.7 3.1 0.1 12.7 3.1 1.5 1 0 0 1 1 1 0 zinc RING finger of MSL2 Dicty_REP PF05086.12 ETO19590.1 - 0.064 11.2 18.5 0.095 10.7 18.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein zf-RING_4 PF14570.6 ETO19590.1 - 0.077 12.8 4.2 0.14 12.0 4.2 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Zf_RING PF16744.5 ETO19590.1 - 0.14 12.2 6.4 0.08 13.1 3.3 2.0 2 0 0 2 2 2 0 KIAA1045 RING finger RINGv PF12906.7 ETO19590.1 - 0.2 11.8 5.0 0.54 10.4 4.9 1.8 1 1 0 1 1 1 0 RING-variant domain DUF1272 PF06906.11 ETO19590.1 - 0.24 11.5 2.9 0.45 10.6 2.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1272) zf-C3H2C3 PF17122.5 ETO19590.1 - 0.24 11.5 4.1 0.49 10.5 4.1 1.6 1 0 0 1 1 1 0 Zinc-finger PHD PF00628.29 ETO19590.1 - 1.3 8.9 5.2 2.8 7.9 5.2 1.6 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 ETO19590.1 - 1.4 8.9 5.0 0.35 10.8 0.8 2.0 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Macoilin PF09726.9 ETO19590.1 - 2.8 6.4 16.4 3.6 6.0 16.4 1.1 1 0 0 1 1 1 0 Macoilin family Glycos_transf_1 PF00534.20 ETO19593.1 - 2.6e-26 92.2 0.0 6.1e-26 91.0 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 ABC_tran PF00005.27 ETO19593.1 - 6e-20 72.2 0.1 1.9e-19 70.5 0.1 1.9 1 1 0 1 1 1 1 ABC transporter Glyco_trans_1_4 PF13692.6 ETO19593.1 - 6.2e-18 65.5 0.0 1.4e-17 64.4 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferases group 1 AAA_21 PF13304.6 ETO19593.1 - 0.0027 17.6 0.4 0.0027 17.6 0.4 3.0 3 2 2 5 5 5 1 AAA domain, putative AbiEii toxin, Type IV TA system Glyco_trans_1_2 PF13524.6 ETO19593.1 - 0.017 15.5 0.0 0.037 14.4 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 AAA_23 PF13476.6 ETO19593.1 - 0.019 15.5 1.2 0.13 12.7 0.0 2.4 2 0 0 2 2 2 0 AAA domain DUF3584 PF12128.8 ETO19593.1 - 0.025 12.1 0.3 0.037 11.6 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) MMR_HSR1 PF01926.23 ETO19593.1 - 0.061 13.4 0.2 0.38 10.8 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase Glyco_transf_4 PF13439.6 ETO19593.1 - 0.063 13.3 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Dynamin_N PF00350.23 ETO19593.1 - 0.088 12.9 0.0 0.16 12.0 0.0 1.5 1 0 0 1 1 1 0 Dynamin family DLIC PF05783.11 ETO19593.1 - 0.13 11.0 0.1 0.21 10.4 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) AAA_29 PF13555.6 ETO19593.1 - 0.17 11.7 0.0 0.45 10.3 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ETO19593.1 - 0.22 11.2 0.0 0.53 10.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain MannoseP_isomer PF01050.18 ETO19594.1 - 2.3e-56 189.9 3.8 2.3e-56 189.9 3.8 2.1 2 0 0 2 2 2 1 Mannose-6-phosphate isomerase NTP_transferase PF00483.23 ETO19594.1 - 2.2e-41 142.1 1.0 5.5e-41 140.8 0.1 2.1 2 2 1 3 3 3 1 Nucleotidyl transferase Cupin_2 PF07883.11 ETO19594.1 - 8.3e-09 35.0 1.1 1.2e-08 34.5 0.3 1.7 2 0 0 2 2 2 1 Cupin domain CENP-C_C PF11699.8 ETO19594.1 - 0.025 14.8 0.1 0.059 13.6 0.1 1.7 1 0 0 1 1 1 0 Mif2/CENP-C like GATase_3 PF07685.14 ETO19594.1 - 0.052 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 CobB/CobQ-like glutamine amidotransferase domain Pkinase PF00069.25 ETO19595.1 - 4.1e-23 82.1 0.6 6.2e-22 78.2 0.6 2.1 1 1 0 1 1 1 1 Protein kinase domain APH PF01636.23 ETO19595.1 - 0.13 12.2 0.1 0.21 11.5 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Ank_4 PF13637.6 ETO19596.1 - 2.4e-16 59.9 0.8 1.8e-09 38.0 0.0 4.1 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO19596.1 - 2.6e-14 53.6 3.1 5.6e-10 39.7 0.1 3.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO19596.1 - 3.1e-10 40.1 1.0 0.00014 22.1 0.0 3.9 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO19596.1 - 6.3e-08 32.3 0.3 1.5 9.6 0.0 4.7 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 ETO19596.1 - 2.4e-07 30.9 0.5 0.13 12.8 0.0 4.2 5 0 0 5 5 5 2 Ankyrin repeat CTP_transf_3 PF02348.19 ETO19596.1 - 0.0051 16.7 0.9 0.0085 16.0 0.9 1.4 1 1 0 1 1 1 1 Cytidylyltransferase 2OG-FeII_Oxy_3 PF13640.6 ETO19597.1 - 4.6e-06 27.4 0.0 7.4e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Kelch_1 PF01344.25 ETO19599.1 - 1.7e-06 27.5 2.6 0.011 15.3 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO19599.1 - 0.0001 22.4 3.7 2 8.8 0.1 4.6 4 1 1 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO19599.1 - 0.0024 17.8 0.2 6.3 6.9 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO19599.1 - 0.0024 18.1 0.0 0.092 13.1 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO19599.1 - 0.0051 16.8 3.7 0.03 14.3 0.1 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO19599.1 - 0.059 13.4 2.8 6.4 6.9 0.0 4.1 5 0 0 5 5 5 0 Kelch motif FH2 PF02181.23 ETO19601.1 - 6.3e-43 147.3 6.4 6.3e-43 147.3 6.4 3.9 4 1 0 4 4 4 1 Formin Homology 2 Domain Secretin_N_2 PF07655.13 ETO19601.1 - 0.74 10.4 65.8 0.45 11.1 6.4 3.9 4 0 0 4 4 4 0 Secretin N-terminal domain SEP PF08059.13 ETO19602.1 - 1e-21 77.3 0.4 2.7e-21 75.9 0.4 1.8 1 0 0 1 1 1 1 SEP domain UBX PF00789.20 ETO19602.1 - 0.00038 20.6 0.0 0.0027 17.8 0.0 2.2 1 1 0 1 1 1 1 UBX domain CEP63 PF17045.5 ETO19603.1 - 0.002 18.1 38.2 0.0033 17.4 38.2 1.3 1 0 0 1 1 1 1 Centrosomal protein of 63 kDa CENP-F_leu_zip PF10473.9 ETO19603.1 - 0.0032 17.5 47.3 0.013 15.6 27.6 2.4 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4472 PF14739.6 ETO19603.1 - 0.0055 17.4 13.4 0.0055 17.4 13.4 3.5 1 1 1 3 3 3 1 Domain of unknown function (DUF4472) COG2 PF06148.11 ETO19603.1 - 0.0084 16.2 24.3 0.23 11.6 2.8 3.3 1 1 2 3 3 3 2 COG (conserved oligomeric Golgi) complex component, COG2 DUF2353 PF09789.9 ETO19603.1 - 0.011 15.1 11.7 0.011 15.1 11.7 2.2 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) ERM PF00769.19 ETO19603.1 - 0.025 14.4 44.4 1 9.2 21.8 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family HMMR_N PF15905.5 ETO19603.1 - 0.036 13.5 47.1 1.8 7.9 23.8 2.0 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Jnk-SapK_ap_N PF09744.9 ETO19603.1 - 0.066 13.4 48.4 0.13 12.5 15.8 3.1 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Filament PF00038.21 ETO19603.1 - 0.13 11.8 38.4 0.17 11.5 10.6 2.4 1 1 1 2 2 2 0 Intermediate filament protein Fez1 PF06818.15 ETO19603.1 - 0.17 12.4 40.0 2.3 8.7 21.5 2.3 1 1 1 2 2 2 0 Fez1 MscS_porin PF12795.7 ETO19603.1 - 0.25 10.8 42.7 7.4 6.0 4.7 3.0 1 1 1 2 2 2 0 Mechanosensitive ion channel porin domain CALCOCO1 PF07888.11 ETO19603.1 - 0.34 9.7 40.7 0.046 12.6 24.6 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1664 PF07889.12 ETO19603.1 - 0.38 10.8 27.2 0.47 10.5 7.6 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) HIP1_clath_bdg PF16515.5 ETO19603.1 - 0.39 11.4 45.4 2.3 8.9 6.3 3.9 1 1 3 4 4 4 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PRKG1_interact PF15898.5 ETO19603.1 - 0.45 11.5 41.2 0.071 14.0 13.1 3.0 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain FlaC_arch PF05377.11 ETO19603.1 - 0.61 10.5 30.6 0.2 12.1 0.9 4.9 4 1 1 5 5 5 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 ETO19603.1 - 0.66 10.5 46.3 0.15 12.6 13.9 2.8 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF4618 PF15397.6 ETO19603.1 - 0.66 9.3 40.5 0.81 9.1 9.4 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4618) GAS PF13851.6 ETO19603.1 - 1.2 8.4 49.0 1.7 7.9 14.4 3.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3847 PF12958.7 ETO19603.1 - 1.3 9.2 33.6 3.6 7.8 0.4 4.7 3 2 2 5 5 5 0 Protein of unknown function (DUF3847) TPR_MLP1_2 PF07926.12 ETO19603.1 - 1.4 9.0 45.0 0.56 10.3 17.2 2.4 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Laminin_II PF06009.12 ETO19603.1 - 1.5 8.8 27.6 0.66 10.0 7.9 3.0 1 1 2 3 3 3 0 Laminin Domain II Uso1_p115_C PF04871.13 ETO19603.1 - 1.6 9.1 43.2 0.4 11.0 9.8 3.1 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region THOC7 PF05615.13 ETO19603.1 - 1.8 8.8 42.6 1.5 9.1 10.3 3.8 1 1 2 3 3 3 0 Tho complex subunit 7 HrpB7 PF09486.10 ETO19603.1 - 1.8 8.9 27.3 0.39 11.1 7.9 3.6 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF4200 PF13863.6 ETO19603.1 - 2.3 8.6 47.9 1.2 9.5 10.0 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4200) DUF3914 PF13053.6 ETO19603.1 - 3.4 8.0 11.2 0.18 12.1 2.2 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF3914) Golgin_A5 PF09787.9 ETO19603.1 - 3.5 7.0 47.3 1.3 8.4 19.4 2.2 1 1 1 2 2 2 0 Golgin subfamily A member 5 IFT57 PF10498.9 ETO19603.1 - 4.4 6.2 39.6 22 3.9 39.6 1.7 1 1 0 1 1 1 0 Intra-flagellar transport protein 57 ATG16 PF08614.11 ETO19603.1 - 4.5 7.4 42.4 20 5.3 14.4 2.3 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) MAD PF05557.13 ETO19603.1 - 5.3 5.3 45.9 14 3.9 45.9 1.6 1 1 0 1 1 1 0 Mitotic checkpoint protein Atg14 PF10186.9 ETO19603.1 - 5.5 6.0 39.7 32 3.5 14.6 2.2 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 ADIP PF11559.8 ETO19603.1 - 5.5 7.1 48.0 0.67 10.0 15.7 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding CCDC-167 PF15188.6 ETO19603.1 - 5.6 7.4 35.7 0.55 10.6 5.4 4.4 1 1 1 3 3 3 0 Coiled-coil domain-containing protein 167 TMF_TATA_bd PF12325.8 ETO19603.1 - 6 7.1 38.5 1.8 8.8 10.0 2.9 1 1 2 3 3 2 0 TATA element modulatory factor 1 TATA binding TMPIT PF07851.13 ETO19603.1 - 6.1 6.0 36.5 2.8 7.1 13.2 2.4 1 1 1 2 2 2 0 TMPIT-like protein FPP PF05911.11 ETO19603.1 - 6.3 4.9 47.3 0.17 10.1 16.9 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil WEMBL PF05701.11 ETO19603.1 - 7.1 5.2 36.8 18 3.8 36.8 1.6 1 1 0 1 1 1 0 Weak chloroplast movement under blue light DUF3584 PF12128.8 ETO19603.1 - 8.3 3.8 38.4 13 3.2 38.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) OmpH PF03938.14 ETO19603.1 - 8.6 6.7 46.1 13 6.1 13.0 2.7 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) ADIP PF11559.8 ETO19604.1 - 0.00012 22.2 32.5 0.026 14.6 9.0 4.1 2 1 2 4 4 4 3 Afadin- and alpha -actinin-Binding Cep57_CLD_2 PF14197.6 ETO19604.1 - 0.0018 18.3 3.0 0.0018 18.3 3.0 4.9 2 2 1 4 4 4 1 Centrosome localisation domain of PPC89 GAS PF13851.6 ETO19604.1 - 0.0023 17.3 29.6 0.23 10.8 0.2 3.2 2 1 1 3 3 3 2 Growth-arrest specific micro-tubule binding BLOC1_2 PF10046.9 ETO19604.1 - 0.0076 16.5 1.6 0.0076 16.5 1.6 3.3 2 1 1 3 3 3 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 bZIP_1 PF00170.21 ETO19604.1 - 0.032 14.3 0.5 0.032 14.3 0.5 4.6 2 1 2 4 4 4 0 bZIP transcription factor DUF4201 PF13870.6 ETO19604.1 - 0.061 13.1 26.1 0.65 9.7 20.8 3.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) Macoilin PF09726.9 ETO19604.1 - 0.078 11.5 15.7 0.14 10.7 11.9 2.2 2 0 0 2 2 2 0 Macoilin family APG6_N PF17675.1 ETO19604.1 - 0.22 12.0 39.0 1.6 9.3 10.9 3.1 2 1 1 3 3 3 0 Apg6 coiled-coil region Atg14 PF10186.9 ETO19604.1 - 0.39 9.7 22.5 2.1 7.4 15.9 2.4 2 1 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Yuri_gagarin PF15934.5 ETO19604.1 - 0.4 10.5 20.6 0.077 12.8 11.3 2.4 1 1 1 2 2 2 0 Yuri gagarin DUF1664 PF07889.12 ETO19604.1 - 0.48 10.5 13.4 7.7 6.6 1.3 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) HAP1_N PF04849.13 ETO19604.1 - 0.72 9.0 30.8 0.82 8.8 24.2 2.1 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Taxilin PF09728.9 ETO19604.1 - 1.6 7.9 31.1 0.042 13.0 8.3 3.0 2 1 0 2 2 2 0 Myosin-like coiled-coil protein DUF2203 PF09969.9 ETO19604.1 - 1.7 9.4 13.9 2.4 8.9 1.7 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) Spc24 PF08286.11 ETO19604.1 - 1.8 8.8 18.0 3.2 8.0 0.0 4.1 2 1 1 3 3 2 0 Spc24 subunit of Ndc80 FapA PF03961.13 ETO19604.1 - 1.9 7.0 19.4 0.24 10.0 4.5 2.9 2 1 1 3 3 3 0 Flagellar Assembly Protein A EzrA PF06160.12 ETO19604.1 - 1.9 6.6 22.5 0.072 11.2 15.2 1.9 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA DUF724 PF05266.14 ETO19604.1 - 1.9 8.3 20.9 1.9 8.3 6.6 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF724) Laminin_I PF06008.14 ETO19604.1 - 2 8.1 21.2 1.4 8.6 13.0 3.0 2 1 1 3 3 3 0 Laminin Domain I PI3K_P85_iSH2 PF16454.5 ETO19604.1 - 2 8.0 26.7 1.5 8.4 11.5 3.4 2 1 1 3 3 3 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain KxDL PF10241.9 ETO19604.1 - 2.1 8.7 20.7 0.57 10.5 2.8 4.0 3 1 2 5 5 4 0 Uncharacterized conserved protein Plasmid_RAQPRD PF09686.10 ETO19604.1 - 2.2 8.5 0.0 2.2 8.5 0.0 3.9 3 2 1 4 4 4 0 Plasmid protein of unknown function (Plasmid_RAQPRD) CENP-F_leu_zip PF10473.9 ETO19604.1 - 2.5 8.1 31.7 2.7 8.0 7.6 3.8 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CALCOCO1 PF07888.11 ETO19604.1 - 2.8 6.7 24.9 0.82 8.5 18.3 2.1 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Phage_GP20 PF06810.11 ETO19604.1 - 3.2 7.6 18.0 2.7 7.8 2.8 3.7 2 1 2 4 4 4 0 Phage minor structural protein GP20 Syntaxin-6_N PF09177.11 ETO19604.1 - 3.3 8.3 13.6 4.9 7.8 5.0 3.3 2 1 1 3 3 3 0 Syntaxin 6, N-terminal HMMR_N PF15905.5 ETO19604.1 - 3.6 7.0 28.3 0.059 12.8 12.3 3.0 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal PEARLI-4 PF05278.12 ETO19604.1 - 3.7 7.1 16.3 0.27 10.8 4.5 3.0 2 1 1 3 3 3 0 Arabidopsis phospholipase-like protein (PEARLI 4) JIP_LZII PF16471.5 ETO19604.1 - 3.7 7.8 21.6 2.3 8.5 0.4 4.4 3 1 1 4 4 4 0 JNK-interacting protein leucine zipper II Acetyltransf_11 PF13720.6 ETO19604.1 - 4.6 7.8 7.4 5.5 7.5 0.1 3.5 3 1 0 3 3 3 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 FUSC PF04632.12 ETO19604.1 - 4.7 5.6 6.7 6.1 5.2 6.1 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family OmpH PF03938.14 ETO19604.1 - 5 7.4 24.0 29 5.0 0.1 3.3 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) YabA PF06156.13 ETO19604.1 - 5.8 7.6 19.0 1 10.0 0.1 3.5 2 1 0 2 2 1 0 Initiation control protein YabA DUF4200 PF13863.6 ETO19604.1 - 6.5 7.2 29.9 7.1 7.1 6.6 3.7 3 1 1 4 4 3 0 Domain of unknown function (DUF4200) DUF4618 PF15397.6 ETO19604.1 - 7.1 6.0 28.3 0.41 10.0 0.8 3.2 2 1 0 3 3 3 0 Domain of unknown function (DUF4618) DUF4407 PF14362.6 ETO19604.1 - 7.2 5.9 19.4 6.8e+02 -0.6 19.7 2.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ZapB PF06005.12 ETO19604.1 - 7.3 7.1 37.8 2.2 8.8 1.6 4.4 2 1 1 3 3 2 0 Cell division protein ZapB Rootletin PF15035.6 ETO19604.1 - 7.4 6.5 28.5 4.8 7.2 1.1 2.6 2 1 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion Seryl_tRNA_N PF02403.22 ETO19604.1 - 8.2 6.7 18.4 0.2 11.9 5.0 3.1 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Lectin_N PF03954.14 ETO19604.1 - 9.3 6.0 21.1 2.1 8.1 0.5 4.0 2 2 2 4 4 4 0 Hepatic lectin, N-terminal domain HIP1_clath_bdg PF16515.5 ETO19604.1 - 9.5 6.9 33.5 8.1 7.1 10.8 3.5 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 ATG16 PF08614.11 ETO19604.1 - 9.6 6.4 32.0 17 5.5 1.3 3.0 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ETO19605.1 - 0.016 15.7 4.9 0.027 14.9 4.9 1.4 1 1 0 1 1 1 0 Fez1 Cellulase-like PF12876.7 ETO19605.1 - 0.02 14.3 0.3 0.029 13.7 0.3 1.2 1 0 0 1 1 1 0 Sugar-binding cellulase-like PYC_OADA PF02436.18 ETO19605.1 - 0.046 13.5 0.7 0.085 12.6 0.7 1.4 1 0 0 1 1 1 0 Conserved carboxylase domain Streptin-Immun PF11083.8 ETO19605.1 - 0.062 13.7 1.0 0.062 13.7 1.0 2.1 3 0 0 3 3 3 0 Lantibiotic streptin immunity protein DXP_synthase_N PF13292.6 ETO19605.1 - 0.087 12.0 0.4 0.15 11.3 0.4 1.3 1 0 0 1 1 1 0 1-deoxy-D-xylulose-5-phosphate synthase DUF1043 PF06295.12 ETO19605.1 - 0.11 12.5 3.6 0.3 11.1 3.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) Halogen_Hydrol PF10112.9 ETO19605.1 - 0.16 11.9 5.3 0.49 10.4 0.4 2.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein BLOC1_2 PF10046.9 ETO19605.1 - 2.7 8.4 8.2 0.29 11.5 3.3 2.0 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FadA PF09403.10 ETO19605.1 - 5.8 7.5 10.8 0.33 11.5 4.9 2.1 2 0 0 2 2 2 0 Adhesion protein FadA CAAD PF14159.6 ETO19606.1 - 0.077 12.8 1.5 0.3 11.0 0.1 2.6 3 0 0 3 3 3 0 CAAD domains of cyanobacterial aminoacyl-tRNA synthetase DUF3484 PF11983.8 ETO19607.1 - 0.023 15.8 16.8 0.47 11.6 7.6 3.6 3 1 0 3 3 3 0 Membrane-attachment and polymerisation-promoting switch AvrL567-A PF11529.8 ETO19607.1 - 0.11 12.6 0.3 0.21 11.8 0.3 1.4 1 0 0 1 1 1 0 Melampsora lini avirulence protein AvrL567-A OAD_gamma PF04277.13 ETO19607.1 - 6.1 7.5 0.0 6.1 7.5 0.0 3.7 4 1 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain SOG2 PF10428.9 ETO19607.1 - 9.8 5.2 26.6 13 4.8 26.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein OSCP PF00213.18 ETO19608.1 - 2.2e-18 67.0 0.1 2.2e-18 67.0 0.1 4.0 5 0 0 5 5 5 1 ATP synthase delta (OSCP) subunit FAM91_C PF14648.6 ETO19608.1 - 0.072 11.9 1.3 0.099 11.5 0.2 1.7 2 0 0 2 2 2 0 FAM91 C-terminus PCRF PF03462.18 ETO19608.1 - 1.3 8.8 13.8 2.2 8.1 0.0 4.4 5 1 0 5 5 5 0 PCRF domain FYVE PF01363.21 ETO19610.1 - 1.1e-06 28.6 1.9 1.6e-06 28.2 0.9 1.7 2 0 0 2 2 2 1 FYVE zinc finger Presenilin PF01080.17 ETO19611.1 - 0.59 8.8 3.1 0.45 9.2 1.0 1.8 2 0 0 2 2 2 0 Presenilin Gp_dh_C PF02800.20 ETO19612.1 - 1.5e-66 222.8 0.0 2.1e-66 222.4 0.0 1.1 1 0 0 1 1 1 1 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain FAM25 PF15825.5 ETO19612.1 - 0.053 13.9 0.2 0.12 12.7 0.2 1.5 1 0 0 1 1 1 0 FAM25 family Semialdhyde_dhC PF02774.18 ETO19612.1 - 0.07 13.2 0.0 0.16 12.0 0.0 1.6 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, dimerisation domain PIG-L PF02585.17 ETO19615.1 - 1.3e-15 58.2 0.0 2e-15 57.6 0.0 1.3 1 0 0 1 1 1 1 GlcNAc-PI de-N-acetylase Pkinase PF00069.25 ETO19616.1 - 0.0051 16.2 1.3 0.0064 15.9 0.0 1.8 3 0 0 3 3 3 1 Protein kinase domain DUF1387 PF07139.11 ETO19616.1 - 0.015 15.0 9.1 0.022 14.5 9.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) NST1 PF13945.6 ETO19616.1 - 4.5 7.3 12.8 0.22 11.6 6.8 1.7 2 0 0 2 2 2 0 Salt tolerance down-regulator Ion_trans PF00520.31 ETO19617.1 - 0.00076 18.8 4.1 0.00076 18.8 4.1 1.7 2 0 0 2 2 2 1 Ion transport protein V_ATPase_I PF01496.19 ETO19618.1 - 9.6e-57 192.5 20.9 9.2e-31 106.6 4.8 2.7 1 1 2 3 3 3 2 V-type ATPase 116kDa subunit family Zn_ribbon_2 PF12674.7 ETO19618.1 - 0.081 13.6 0.4 0.29 11.8 0.4 2.0 1 0 0 1 1 1 0 Putative zinc ribbon domain APC_u15 PF16636.5 ETO19618.1 - 0.78 10.2 4.0 2.4 8.6 4.0 1.8 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr regions 5 and 6 Menin PF05053.13 ETO19618.1 - 2.6 6.3 6.5 3.9 5.7 6.5 1.2 1 0 0 1 1 1 0 Menin PBP1_TM PF14812.6 ETO19618.1 - 5.8 7.4 8.8 1.1 9.7 2.9 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Papo_T_antigen PF02380.15 ETO19619.1 - 0.00027 21.0 1.0 0.00027 21.0 1.0 1.8 2 0 0 2 2 2 1 T-antigen specific domain Ydc2-catalyt PF09159.10 ETO19619.1 - 0.022 14.5 0.1 0.029 14.1 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial resolvase Ydc2 / RNA splicing MRS1 SSP160 PF06933.11 ETO19620.1 - 0.095 10.9 12.1 0.11 10.7 12.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Dicty_REP PF05086.12 ETO19620.1 - 0.28 9.1 7.1 0.36 8.7 7.1 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO19620.1 - 0.67 9.9 18.8 1.2 9.2 18.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TMEM173 PF15009.6 ETO19620.1 - 1 8.5 4.3 0.21 10.7 1.1 1.4 2 0 0 2 2 2 0 Transmembrane protein 173 B277 PF17623.2 ETO19620.1 - 1 8.4 6.6 1.5 7.9 6.6 1.2 1 0 0 1 1 1 0 Domain of unknown function Tir_receptor_C PF07489.11 ETO19620.1 - 2.5 8.0 7.0 4.1 7.3 7.0 1.3 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Nucleoporin2 PF04096.14 ETO19622.1 - 6.3e-25 88.0 0.0 1.1e-24 87.2 0.0 1.4 1 0 0 1 1 1 1 Nucleoporin autopeptidase SPACA7 PF15307.6 ETO19623.1 - 0.075 13.3 1.7 0.13 12.5 1.7 1.3 1 0 0 1 1 1 0 Sperm acrosome-associated protein 7 DUF2951 PF11166.8 ETO19624.1 - 0.059 13.6 0.3 1.8 8.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) TRAPPC-Trs85 PF12739.7 ETO19626.1 - 0.016 14.2 0.1 0.026 13.5 0.1 1.2 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit ApbA_C PF08546.11 ETO19627.1 - 5.1e-30 104.2 0.0 7.9e-30 103.6 0.0 1.3 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA C terminal ApbA PF02558.16 ETO19627.1 - 1.8e-15 56.9 0.1 4.6e-15 55.6 0.1 1.7 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA TPR_1 PF00515.28 ETO19628.1 - 1.6e-11 43.5 7.4 2.2e-07 30.4 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO19628.1 - 2.8e-10 39.5 4.7 0.00021 21.2 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO19628.1 - 1.1e-07 32.1 1.1 0.00019 21.6 0.2 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19628.1 - 1.9e-06 27.6 5.9 0.00011 22.1 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ETO19628.1 - 0.03 14.3 0.2 0.03 14.3 0.2 2.9 2 1 1 3 3 3 0 Putative TPR-like repeat TPR_11 PF13414.6 ETO19628.1 - 0.041 13.6 1.4 0.35 10.6 0.3 2.8 2 1 0 2 2 2 0 TPR repeat SHNi-TPR PF10516.9 ETO19628.1 - 0.058 12.8 0.0 9.3 5.8 0.0 2.8 2 0 0 2 2 2 0 SHNi-TPR TPR_17 PF13431.6 ETO19628.1 - 0.49 10.9 0.1 0.49 10.9 0.1 2.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO19628.1 - 1.5 8.9 6.3 31 4.8 0.1 3.8 3 1 1 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat Vpu PF00558.19 ETO19629.1 - 0.073 12.9 0.2 0.073 12.9 0.2 2.7 2 1 0 2 2 2 0 Vpu protein Tom22 PF04281.13 ETO19629.1 - 0.12 12.1 5.5 4.4 7.1 5.5 2.2 1 1 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 Polysacc_synt_4 PF04669.13 ETO19630.1 - 4.5e-06 26.4 0.1 9.9e-06 25.2 0.1 1.6 1 1 0 1 1 1 1 Polysaccharide biosynthesis PUF PF00806.19 ETO19631.1 - 6.3e-17 60.2 9.7 0.00039 19.9 0.2 4.6 4 0 0 4 4 4 4 Pumilio-family RNA binding repeat PUF PF00806.19 ETO19632.1 - 8.1e-18 63.0 1.7 8.8e-06 25.1 0.2 3.3 3 0 0 3 3 3 3 Pumilio-family RNA binding repeat GED PF02212.18 ETO19632.1 - 0.0021 18.2 1.3 0.42 10.8 0.3 2.3 2 0 0 2 2 2 2 Dynamin GTPase effector domain CPL PF08144.11 ETO19632.1 - 0.0065 16.8 0.6 2.4 8.5 0.1 2.1 1 1 1 2 2 2 2 CPL (NUC119) domain TFIID-31kDa PF02291.15 ETO19632.1 - 0.0067 16.5 0.1 0.0085 16.2 0.1 1.1 1 0 0 1 1 1 1 Transcription initiation factor IID, 31kD subunit YqzH PF14164.6 ETO19632.1 - 0.032 14.3 0.9 0.13 12.4 0.1 2.2 2 1 0 2 2 2 0 YqzH-like protein GerD PF17898.1 ETO19632.1 - 0.046 13.7 0.4 0.081 12.9 0.4 1.5 1 0 0 1 1 1 0 Spore germination GerD central core domain Comm PF15957.5 ETO19635.1 - 0.12 12.7 0.0 0.33 11.3 0.0 1.8 1 0 0 1 1 1 0 Commissureless DUF3139 PF11337.8 ETO19635.1 - 0.26 12.0 5.9 0.74 10.5 5.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF4492 PF14899.6 ETO19635.1 - 0.44 10.5 7.0 0.82 9.6 7.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4492) Saf_2TM PF18303.1 ETO19635.1 - 0.52 9.9 4.0 0.97 9.0 4.0 1.3 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain Tmemb_9 PF05434.11 ETO19635.1 - 3.9 7.4 11.2 0.29 11.0 3.3 2.6 2 0 0 2 2 2 0 TMEM9 CAP_GLY PF01302.25 ETO19636.1 - 5.8e-08 32.6 0.1 9.8e-08 31.9 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain Fez1 PF06818.15 ETO19636.1 - 0.023 15.2 3.5 0.14 12.6 0.1 2.4 2 1 0 2 2 2 0 Fez1 Enkurin PF13864.6 ETO19636.1 - 0.087 13.3 1.9 2.3 8.7 0.2 2.3 2 0 0 2 2 2 0 Calmodulin-binding DUF536 PF04394.14 ETO19636.1 - 8.7 6.3 8.4 3.9 7.4 0.8 2.5 2 0 0 2 2 2 0 Protein of unknown function, DUF536 Ni_hydr_CYTB PF01292.20 ETO19638.1 - 0.006 16.2 0.0 0.0075 15.9 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 Shisa PF13908.6 ETO19638.1 - 0.012 15.8 0.4 0.15 12.3 0.1 2.0 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF2973 PF11189.8 ETO19638.1 - 0.026 14.6 0.2 4.4 7.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2973) RanGAP1_C PF07834.11 ETO19638.1 - 0.04 13.5 0.1 0.073 12.7 0.1 1.5 1 0 0 1 1 1 0 RanGAP1 C-terminal domain COX16 PF14138.6 ETO19638.1 - 0.15 12.6 0.1 6.8 7.3 0.1 2.2 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 CLN3 PF02487.17 ETO19639.1 - 0.52 9.3 5.7 9.1 5.2 0.0 2.4 2 0 0 2 2 2 0 CLN3 protein Zip PF02535.22 ETO19639.1 - 9.7 5.3 5.7 88 2.2 6.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Metallophos PF00149.28 ETO19640.1 - 3.1e-09 37.6 0.1 6.6e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Cyt-b5 PF00173.28 ETO19641.1 - 4.7e-12 45.9 0.0 8e-12 45.1 0.0 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain FA_desaturase PF00487.24 ETO19642.1 - 2.8e-25 89.6 14.6 8.1e-25 88.1 14.6 1.6 1 1 0 1 1 1 1 Fatty acid desaturase Ldl_recept_a PF00057.18 ETO19643.1 - 0.076 13.2 3.0 0.092 13.0 0.9 2.2 2 0 0 2 2 2 0 Low-density lipoprotein receptor domain class A Glyco_hydro_125 PF06824.11 ETO19644.1 - 0.0036 16.3 0.3 0.005 15.8 0.3 1.2 1 0 0 1 1 1 1 Metal-independent alpha-mannosidase (GH125) SPRY PF00622.28 ETO19646.1 - 7e-10 39.1 0.1 8.6e-10 38.8 0.1 1.1 1 0 0 1 1 1 1 SPRY domain Neuralized PF07177.12 ETO19646.1 - 0.023 14.7 0.0 0.023 14.7 0.0 1.1 1 0 0 1 1 1 0 Neuralized Helicase_IV_N PF12462.8 ETO19647.1 - 0.0041 17.1 1.6 0.0058 16.6 1.6 1.2 1 0 0 1 1 1 1 DNA helicase IV / RNA helicase N terminal Paramyxo_C PF01692.18 ETO19647.1 - 0.015 14.7 1.6 0.019 14.4 0.5 1.5 1 1 0 1 1 1 0 Paramyxovirus non-structural protein C FAM76 PF16046.5 ETO19647.1 - 0.03 13.7 8.2 0.036 13.4 8.2 1.0 1 0 0 1 1 1 0 FAM76 protein Tau95 PF09734.9 ETO19647.1 - 0.17 12.6 3.2 0.25 12.1 3.2 1.4 1 1 0 1 1 1 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain Acyl_transf_3 PF01757.22 ETO19649.1 - 0.064 12.3 0.7 0.087 11.9 0.7 1.1 1 0 0 1 1 1 0 Acyltransferase family SLATT_1 PF18181.1 ETO19649.1 - 0.16 11.9 1.8 0.64 10.0 0.0 2.5 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 TPR_12 PF13424.6 ETO19650.1 - 4.3e-33 113.4 6.4 7.5e-16 58.2 0.0 4.5 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO19650.1 - 2.7e-25 87.1 25.1 3e-07 30.0 0.4 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO19650.1 - 3.4e-22 76.7 15.9 1.2e-05 25.0 0.3 6.2 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO19650.1 - 4.2e-21 74.1 0.8 6.6e-06 25.8 0.0 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19650.1 - 1e-19 69.0 21.0 5.4e-06 26.2 0.6 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO19650.1 - 1.5e-19 68.5 2.5 8.5e-06 25.4 0.0 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO19650.1 - 7.5e-09 35.4 1.1 0.06 13.7 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO19650.1 - 9.9e-08 32.2 6.2 0.93 10.3 0.0 5.8 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO19650.1 - 2.7e-05 24.6 0.0 5.8 8.0 0.0 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO19650.1 - 0.00014 21.9 0.3 0.0076 16.2 0.0 2.3 1 1 0 2 2 2 1 Caspase domain MIT PF04212.18 ETO19650.1 - 0.00021 21.3 11.9 0.14 12.3 0.5 5.1 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO19650.1 - 0.00097 18.8 0.5 0.00097 18.8 0.5 6.2 7 1 1 8 8 7 1 TPR repeat TPR_19 PF14559.6 ETO19650.1 - 0.0046 17.4 0.3 4.6 7.8 0.0 4.0 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO19650.1 - 0.0054 17.4 0.7 3.2 8.5 0.0 3.5 4 0 0 4 4 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO19650.1 - 0.015 15.0 9.9 0.12 12.1 3.0 2.8 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 ETO19650.1 - 0.037 14.0 9.8 1.3 9.0 0.3 4.2 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO19650.1 - 0.14 12.0 9.3 2.3 8.0 0.7 3.8 2 2 0 2 2 2 0 Domain of unknown function (DUF5113) DUF3856 PF12968.7 ETO19650.1 - 0.25 11.4 2.0 4.8 7.2 0.1 3.1 3 1 0 3 3 3 0 Domain of Unknown Function (DUF3856) DUF627 PF04781.12 ETO19650.1 - 0.47 10.5 5.9 17 5.5 0.2 4.0 3 1 0 4 4 3 0 Protein of unknown function (DUF627) ANAPC3 PF12895.7 ETO19650.1 - 0.52 10.6 4.4 5 7.4 0.1 3.3 1 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ETO19650.1 - 1.5 9.3 3.4 40 4.8 0.1 3.6 3 0 0 3 3 3 0 PPR repeat VPS13 PF16908.5 ETO19652.1 - 4.3e-24 85.6 20.1 4.3e-14 52.9 12.3 4.1 3 1 0 3 3 3 2 Vacuolar sorting-associated protein 13, N-terminal GEN1_C PF18380.1 ETO19652.1 - 0.049 14.5 1.5 0.049 14.5 1.5 3.5 3 1 0 3 3 3 0 Holliday junction resolvase Gen1 C-terminal domain DUF4864 PF16156.5 ETO19652.1 - 0.12 13.1 2.0 1.5 9.6 0.5 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4864) DUF1011 PF06237.12 ETO19653.1 - 2.2e-22 79.2 8.3 2.2e-22 79.2 8.3 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1011) Nucleoside_tran PF01733.18 ETO19653.1 - 8.7e-05 22.1 9.1 0.0043 16.5 0.1 2.9 3 0 0 3 3 3 2 Nucleoside transporter Phage_holin_3_6 PF07332.11 ETO19653.1 - 0.12 12.5 0.2 0.12 12.5 0.2 3.0 3 0 0 3 3 3 0 Putative Actinobacterial Holin-X, holin superfamily III Pex24p PF06398.11 ETO19653.1 - 0.25 10.3 4.9 0.82 8.6 4.9 1.8 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin SBBP PF06739.11 ETO19653.1 - 1.1 9.3 4.9 4.6 7.3 0.8 2.4 2 0 0 2 2 2 0 Beta-propeller repeat zf-RING_2 PF13639.6 ETO19654.1 - 7.4e-06 26.2 5.4 1.3e-05 25.4 5.4 1.4 1 0 0 1 1 1 1 Ring finger domain RINGv PF12906.7 ETO19654.1 - 0.00075 19.6 4.1 0.0018 18.4 4.1 1.7 1 0 0 1 1 1 1 RING-variant domain zf-RING_UBOX PF13445.6 ETO19654.1 - 0.0014 18.6 5.1 0.0032 17.4 5.1 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO19654.1 - 0.0025 17.6 2.8 0.0052 16.6 2.8 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO19654.1 - 0.0052 16.6 5.3 0.01 15.7 5.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO19654.1 - 0.0069 16.7 4.4 0.027 14.8 4.4 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO19654.1 - 0.027 14.5 0.4 0.05 13.6 0.4 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zf_RING PF16744.5 ETO19654.1 - 0.21 11.7 1.8 0.52 10.5 1.8 1.6 1 0 0 1 1 1 0 KIAA1045 RING finger zf-C3HC4_4 PF15227.6 ETO19654.1 - 0.48 10.6 4.8 1.2 9.4 4.8 1.7 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ETO19654.1 - 0.89 9.3 7.8 1.9 8.3 7.8 1.5 1 0 0 1 1 1 0 RING-like zinc finger SOBP PF15279.6 ETO19654.1 - 4.1 7.9 33.2 6.7 7.2 33.2 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein SDA1 PF05285.12 ETO19655.1 - 1.3e-05 24.9 28.7 1.8e-05 24.4 28.7 1.3 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO19655.1 - 0.0027 16.0 33.9 0.0037 15.6 33.9 1.1 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.10 ETO19655.1 - 0.31 10.4 34.5 0.48 9.7 34.5 1.3 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO19655.1 - 3.4 6.3 11.1 4.8 5.8 11.1 1.3 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 ETO19655.1 - 6.4 5.4 17.0 11 4.7 17.0 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CENP-B_dimeris PF09026.10 ETO19656.1 - 0.031 14.7 1.3 0.046 14.1 1.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.11 ETO19656.1 - 0.17 9.9 2.4 0.24 9.5 2.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen zf-MYND PF01753.18 ETO19656.1 - 0.38 10.9 6.4 0.67 10.1 6.4 1.4 1 0 0 1 1 1 0 MYND finger DUF2175 PF09943.9 ETO19656.1 - 1.6 9.1 6.3 25 5.2 2.2 2.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) NT-C2 PF10358.9 ETO19657.1 - 0.0058 16.3 2.3 0.0058 16.3 2.3 2.0 2 1 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins ABC2_membrane_3 PF12698.7 ETO19657.1 - 0.052 12.7 0.2 0.061 12.4 0.2 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Ctr PF04145.15 ETO19657.1 - 0.54 10.9 5.1 0.26 11.9 2.1 2.2 2 1 0 2 2 2 0 Ctr copper transporter family AMP-binding PF00501.28 ETO19658.1 - 6e-19 67.9 0.0 6.6e-19 67.8 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme Thioredoxin_5 PF13743.6 ETO19659.1 - 0.037 13.7 0.0 0.083 12.6 0.0 1.6 1 0 0 1 1 1 0 Thioredoxin ATG27 PF09451.10 ETO19660.1 - 4.5 7.0 5.8 9.5 6.0 5.8 1.6 1 1 0 1 1 1 0 Autophagy-related protein 27 PHD PF00628.29 ETO19661.1 - 1.8e-10 40.5 2.3 4e-10 39.4 2.3 1.6 1 0 0 1 1 1 1 PHD-finger ETRAMP PF09716.10 ETO19661.1 - 0.026 14.6 0.6 0.049 13.7 0.6 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3795 PF12675.7 ETO19661.1 - 4.7 7.7 8.2 0.32 11.5 1.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3795) U3_snoRNA_assoc PF08297.11 ETO19662.1 - 0.45 11.3 15.9 0.48 11.2 15.9 1.0 1 0 0 1 1 1 0 U3 snoRNA associated FCP1_C PF09309.10 ETO19662.1 - 2 8.3 14.9 2.2 8.1 14.9 1.1 1 0 0 1 1 1 0 FCP1, C-terminal DUF3807 PF12720.7 ETO19662.1 - 3.6 7.8 18.2 3.8 7.7 18.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SR-25 PF10500.9 ETO19662.1 - 5.1 6.6 22.9 5.4 6.5 22.9 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein RNA_pol_Rpc4 PF05132.14 ETO19662.1 - 7.5 7.0 15.8 8.2 6.8 15.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Peptidase_M16_C PF05193.21 ETO19663.1 - 5.2e-14 52.7 0.0 1.1e-13 51.7 0.0 1.5 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ETO19663.1 - 4.9e-10 39.6 0.0 7.6e-10 38.9 0.0 1.3 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) DUF4271 PF14093.6 ETO19664.1 - 0.044 13.7 8.7 0.064 13.2 8.7 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) DUF4050 PF13259.6 ETO19665.1 - 0.021 15.2 0.8 0.036 14.4 0.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) Med3 PF11593.8 ETO19665.1 - 0.28 10.4 4.4 0.45 9.6 4.4 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Ribosomal_60s PF00428.19 ETO19665.1 - 1.2 9.7 5.1 0.5 11.0 0.3 2.4 2 0 0 2 2 2 0 60s Acidic ribosomal protein Peptidase_S49_N PF08496.10 ETO19665.1 - 6.9 6.7 9.5 26 4.8 9.5 1.9 1 1 0 1 1 1 0 Peptidase family S49 N-terminal RRM_1 PF00076.22 ETO19666.1 - 1.8e-14 53.3 0.0 3.2e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO19666.1 - 0.0012 18.8 0.0 0.0018 18.3 0.0 1.2 1 0 0 1 1 1 1 RNA binding domain Mannosyl_trans3 PF11051.8 ETO19668.1 - 0.019 14.4 0.8 0.034 13.5 0.8 1.4 1 0 0 1 1 1 0 Mannosyltransferase putative RhoGAP PF00620.27 ETO19671.1 - 8.3e-07 29.0 0.3 1.7e-06 27.9 0.0 1.6 2 0 0 2 2 2 1 RhoGAP domain PHO4 PF01384.20 ETO19671.1 - 1.3 8.0 4.0 0.21 10.6 0.4 1.9 2 1 0 2 2 2 0 Phosphate transporter family ETRAMP PF09716.10 ETO19671.1 - 9.9 6.3 6.4 11 6.2 0.0 3.8 4 1 0 4 4 4 0 Malarial early transcribed membrane protein (ETRAMP) PI3K_1B_p101 PF10486.9 ETO19672.1 - 0.036 11.9 2.5 0.043 11.6 2.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MMU163 PF17119.5 ETO19672.1 - 0.16 11.1 5.0 0.17 11.0 5.0 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Hid1 PF12722.7 ETO19672.1 - 0.76 7.8 9.6 0.82 7.7 9.6 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Apt1 PF10351.9 ETO19672.1 - 0.81 8.5 11.4 0.93 8.3 11.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ETO19672.1 - 1.4 7.4 14.2 1.4 7.4 14.2 1.0 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 ETO19672.1 - 1.8 7.3 5.6 2.1 7.1 5.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO19672.1 - 3.4 6.3 11.8 3.9 6.1 11.8 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO19672.1 - 4.6 5.4 9.7 4.8 5.4 9.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO19672.1 - 6 5.1 12.7 8 4.7 12.7 1.3 1 0 0 1 1 1 0 Menin RXT2_N PF08595.11 ETO19673.1 - 0.003 17.6 1.0 0.0051 16.9 1.0 1.6 1 0 0 1 1 1 1 RXT2-like, N-terminal FYVE PF01363.21 ETO19675.1 - 2.7e-14 53.0 7.0 2.7e-14 53.0 7.0 2.7 3 1 0 3 3 3 1 FYVE zinc finger Sre PF03125.18 ETO19675.1 - 0.25 10.4 1.6 0.41 9.7 1.6 1.3 1 0 0 1 1 1 0 C. elegans Sre G protein-coupled chemoreceptor PNISR PF15996.5 ETO19675.1 - 2.2 8.5 14.1 0.2 11.9 3.9 2.8 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 ETO19675.1 - 3.5 6.3 18.6 0.18 10.6 6.8 2.4 2 0 0 2 2 2 0 Presenilin CPSF100_C PF13299.6 ETO19675.1 - 7.5 6.7 12.8 1.8 8.7 2.9 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Packaging_FI PF14000.6 ETO19676.1 - 0.0012 19.3 0.1 0.0016 18.9 0.1 1.1 1 0 0 1 1 1 1 DNA packaging protein FI Secretin_N_2 PF07655.13 ETO19676.1 - 0.012 16.1 7.4 0.017 15.6 7.4 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain CFIA_Pcf11 PF11526.8 ETO19676.1 - 0.02 15.4 7.2 0.042 14.3 5.9 1.9 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 SRP9-21 PF05486.12 ETO19676.1 - 0.035 14.5 0.1 0.051 14.0 0.1 1.2 1 0 0 1 1 1 0 Signal recognition particle 9 kDa protein (SRP9) DUF2457 PF10446.9 ETO19677.1 - 0.091 11.9 17.2 0.13 11.4 17.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO19677.1 - 0.099 10.8 10.1 0.13 10.5 10.1 1.1 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ETO19677.1 - 0.23 11.6 7.9 0.35 10.9 7.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein BUD22 PF09073.10 ETO19677.1 - 0.26 10.6 7.6 0.26 10.6 7.6 1.1 1 0 0 1 1 1 0 BUD22 RXT2_N PF08595.11 ETO19677.1 - 0.47 10.5 7.7 0.69 9.9 7.7 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_RNA_Pol_19 PF05320.12 ETO19677.1 - 0.48 10.4 8.3 0.82 9.6 8.3 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit CDC45 PF02724.14 ETO19677.1 - 0.8 7.9 11.6 1 7.6 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO19677.1 - 1.2 8.5 11.3 1.7 8.0 11.3 1.1 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 ETO19677.1 - 1.5 8.7 6.9 2 8.3 6.9 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region Sporozoite_P67 PF05642.11 ETO19677.1 - 3.1 5.7 7.9 3.9 5.5 7.9 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 ETO19677.1 - 3.8 5.5 17.3 4.8 5.1 17.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi COPI_C PF06957.11 ETO19677.1 - 5.2 5.7 6.0 6.8 5.3 6.0 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus RRN3 PF05327.11 ETO19677.1 - 5.6 5.4 12.7 7.3 5.0 12.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Rhomboid PF01694.22 ETO19678.1 - 2.5e-14 53.5 14.4 2.5e-14 53.5 14.4 2.0 1 1 1 2 2 2 1 Rhomboid family Ac76 PF05814.11 ETO19678.1 - 0.049 13.6 0.7 0.049 13.6 0.7 2.6 3 0 0 3 3 3 0 Orf76 (Ac76) DUF1751 PF08551.10 ETO19678.1 - 3.9 8.1 11.2 0.19 12.3 2.2 2.6 3 0 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) SAS-6_N PF16531.5 ETO19680.1 - 0.00088 19.8 0.0 0.00088 19.8 0.0 3.3 3 0 0 3 3 3 1 Centriolar protein SAS N-terminal Tektin PF03148.14 ETO19680.1 - 0.0009 18.1 3.3 0.0009 18.1 3.3 4.1 2 2 2 4 4 4 4 Tektin family Metal_resist PF13801.6 ETO19680.1 - 0.19 11.9 9.3 0.23 11.7 0.2 3.2 2 1 1 3 3 3 0 Heavy-metal resistance MotY_N PF18393.1 ETO19680.1 - 0.48 10.6 12.9 0.61 10.2 3.4 2.4 2 0 0 2 2 2 0 MotY N-terminal domain HisKA_3 PF07730.13 ETO19680.1 - 0.84 10.2 4.1 5.3 7.6 0.1 3.5 3 0 0 3 3 3 0 Histidine kinase Spc7 PF08317.11 ETO19680.1 - 8.9 5.1 66.5 0.15 10.9 14.7 3.2 1 1 2 3 3 3 0 Spc7 kinetochore protein TPR_12 PF13424.6 ETO19681.1 - 0.0011 19.2 0.0 0.0018 18.5 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO19681.1 - 0.0029 17.7 1.8 0.0059 16.7 0.6 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat Csm1_N PF18504.1 ETO19682.1 - 0.022 15.1 1.3 0.079 13.3 1.3 2.0 1 0 0 1 1 1 0 Csm1 N-terminal domain Cnn_1N PF07989.11 ETO19682.1 - 0.046 13.9 1.8 0.087 13.0 0.6 2.2 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Bep_C_terminal PF17841.1 ETO19683.1 - 0.038 14.2 0.4 0.1 12.9 0.0 1.8 2 0 0 2 2 2 0 BID domain of Bartonella effector protein (Bep) LicD PF04991.13 ETO19683.1 - 0.22 11.6 12.8 0.047 13.8 4.9 2.3 1 1 1 2 2 2 0 LicD family HDA2-3 PF11496.8 ETO19684.1 - 0.0058 15.8 3.3 0.0076 15.5 3.3 1.1 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 RE_Eco29kI PF09517.10 ETO19685.1 - 0.027 14.1 0.1 0.041 13.5 0.1 1.3 1 0 0 1 1 1 0 Eco29kI restriction endonuclease SDA1 PF05285.12 ETO19685.1 - 0.05 13.0 14.2 0.058 12.8 14.2 1.1 1 0 0 1 1 1 0 SDA1 SOG2 PF10428.9 ETO19685.1 - 0.14 11.3 12.5 0.15 11.2 12.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein TEX19 PF15553.6 ETO19685.1 - 0.19 11.7 2.4 0.21 11.5 1.6 1.4 1 1 0 1 1 1 0 Testis-expressed protein 19 Raftlin PF15250.6 ETO19685.1 - 0.21 10.3 9.5 0.22 10.2 9.5 1.1 1 0 0 1 1 1 0 Raftlin Nop14 PF04147.12 ETO19685.1 - 0.33 9.1 13.1 0.36 9.0 13.1 1.0 1 0 0 1 1 1 0 Nop14-like family Utp14 PF04615.13 ETO19685.1 - 0.54 8.8 15.2 0.61 8.6 15.2 1.0 1 0 0 1 1 1 0 Utp14 protein Apt1 PF10351.9 ETO19685.1 - 0.66 8.8 13.7 0.68 8.7 13.7 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Hid1 PF12722.7 ETO19685.1 - 0.77 7.8 12.3 0.91 7.6 12.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO19685.1 - 2.1 7.0 12.7 2.4 6.8 12.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO19685.1 - 3.9 5.6 12.6 4.5 5.5 12.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2981 PF11200.8 ETO19685.1 - 6.2 6.5 6.7 6.9 6.3 6.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Kinase-PolyVal PF18762.1 ETO19686.1 - 0.0042 17.1 1.2 0.0042 17.1 1.2 1.7 2 0 0 2 2 2 1 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins Cnd1 PF12717.7 ETO19687.1 - 2.2e-05 24.6 0.5 0.0022 18.1 0.1 2.3 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1 CLASP_N PF12348.8 ETO19687.1 - 0.0086 15.7 0.4 0.023 14.3 0.1 1.8 2 0 0 2 2 2 1 CLASP N terminal RPN7 PF10602.9 ETO19688.1 - 0.04 13.6 0.1 0.071 12.8 0.1 1.4 1 0 0 1 1 1 0 26S proteasome subunit RPN7 DUF835 PF05763.12 ETO19688.1 - 0.056 13.2 0.1 0.094 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF835) Piwi PF02171.17 ETO19689.1 - 9e-18 64.5 0.0 3.2e-17 62.7 0.0 1.8 1 1 1 2 2 2 1 Piwi domain Ndc1_Nup PF09531.10 ETO19689.1 - 0.46 9.1 4.4 0.6 8.7 4.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Mitofilin PF09731.9 ETO19689.1 - 5.2 5.8 41.3 7.5 5.3 41.3 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Vps52 PF04129.12 ETO19690.1 - 7.5e-22 77.7 0.5 7.5e-22 77.7 0.5 1.6 2 0 0 2 2 2 1 Vps52 / Sac2 family Exo70 PF03081.15 ETO19690.1 - 0.015 14.4 4.1 0.017 14.2 2.7 1.7 1 1 0 1 1 1 0 Exo70 exocyst complex subunit Hormone_1 PF00103.20 ETO19690.1 - 0.043 13.6 2.8 0.042 13.6 1.3 1.6 1 1 0 1 1 1 0 Somatotropin hormone family Vps52 PF04129.12 ETO19691.1 - 3e-22 79.0 9.9 3.6e-22 78.8 9.9 1.0 1 0 0 1 1 1 1 Vps52 / Sac2 family RPN6_N PF18055.1 ETO19691.1 - 0.077 13.4 0.3 0.12 12.8 0.3 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN6 N-terminal domain zf-TRAF PF02176.18 ETO19692.1 - 0.00016 22.3 3.1 0.00016 22.3 3.1 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger WD40 PF00400.32 ETO19693.1 - 2.9e-16 59.6 11.5 6.3e-07 30.0 1.4 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO19693.1 - 0.0018 17.0 1.3 0.0035 16.0 1.3 1.5 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO19693.1 - 0.012 15.9 0.0 0.23 11.8 0.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Piezo_RRas_bdg PF12166.8 ETO19694.1 - 5.5e-65 220.3 3.7 9.5e-62 209.6 3.7 2.3 1 1 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain Secretin_N_2 PF07655.13 ETO19695.1 - 0.048 14.2 31.0 0.55 10.8 12.4 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain SR-25 PF10500.9 ETO19695.1 - 0.089 12.4 15.7 0.23 11.0 7.2 2.6 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein PH_11 PF15413.6 ETO19695.1 - 0.3 11.5 8.1 0.037 14.5 2.5 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain Mito_fiss_reg PF05308.11 ETO19695.1 - 0.72 9.9 20.1 0.11 12.5 14.7 2.4 2 1 0 2 2 2 0 Mitochondrial fission regulator PH_12 PF16457.5 ETO19695.1 - 2.6 8.6 9.2 0.15 12.6 0.9 2.4 2 0 0 2 2 2 0 Pleckstrin homology domain Menin PF05053.13 ETO19695.1 - 9.4 4.4 16.2 6 5.1 7.1 2.1 2 0 0 2 2 2 0 Menin PH PF00169.29 ETO19697.1 - 3.1e-10 40.5 0.4 5e-10 39.8 0.4 1.3 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO19697.1 - 6.1e-09 35.9 0.1 8.7e-09 35.4 0.1 1.2 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO19697.1 - 2.8e-06 27.5 0.2 4e-06 27.0 0.2 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO19697.1 - 0.0063 16.9 1.0 0.014 15.8 0.2 1.7 1 1 1 2 2 2 1 Pleckstrin homology domain Myosin_TH1 PF06017.13 ETO19697.1 - 0.044 13.5 0.0 0.056 13.1 0.0 1.1 1 0 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding Vps53_N PF04100.12 ETO19698.1 - 7.8e-05 21.8 0.0 0.00017 20.7 0.0 1.5 1 0 0 1 1 1 1 Vps53-like, N-terminal RAI1 PF08652.11 ETO19699.1 - 0.018 15.3 0.0 0.066 13.4 0.0 2.0 1 0 0 1 1 1 0 RAI1 like PD-(D/E)XK nuclease VPS9 PF02204.18 ETO19699.1 - 0.061 13.6 0.9 0.39 10.9 0.1 2.6 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain FAM60A PF15396.6 ETO19699.1 - 1.4 8.9 7.4 0.14 12.1 1.7 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Dynamin_N PF00350.23 ETO19701.1 - 2.8e-16 60.0 0.9 5.8e-07 29.7 0.4 2.9 1 1 1 2 2 2 2 Dynamin family MMR_HSR1 PF01926.23 ETO19701.1 - 1e-12 48.1 0.9 2.4e-12 47.0 0.2 2.0 2 0 0 2 2 2 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO19701.1 - 3.2e-06 26.8 1.3 2.1e-05 24.1 0.3 2.4 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ETO19701.1 - 1.4e-05 24.6 1.6 0.017 14.6 1.6 2.5 1 1 0 1 1 1 1 Ferrous iron transport protein B Gtr1_RagA PF04670.12 ETO19701.1 - 2.1e-05 24.0 1.7 2.6e-05 23.7 0.2 1.9 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ETO19701.1 - 5.9e-05 23.0 0.1 0.065 13.1 0.0 3.0 2 1 0 2 2 2 2 RsgA GTPase IIGP PF05049.13 ETO19701.1 - 7.7e-05 21.9 1.3 0.0036 16.4 0.9 2.5 2 1 0 2 2 2 1 Interferon-inducible GTPase (IIGP) cobW PF02492.19 ETO19701.1 - 0.014 15.0 0.6 0.014 15.0 0.6 2.2 3 1 0 3 3 3 0 CobW/HypB/UreG, nucleotide-binding domain Roc PF08477.13 ETO19701.1 - 0.68 10.2 7.0 1 9.6 0.1 3.4 4 0 0 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase MCM_OB PF17207.3 ETO19702.1 - 3.6e-16 59.2 1.9 3.6e-16 59.2 1.9 2.0 2 0 0 2 2 2 1 MCM OB domain PADR1 PF08063.12 ETO19702.1 - 1.4 8.8 5.4 0.19 11.5 0.3 2.1 2 0 0 2 2 2 0 PADR1 (NUC008) domain MCM_N PF14551.6 ETO19703.1 - 3.1e-07 30.9 2.3 5e-07 30.3 2.3 1.4 1 0 0 1 1 1 1 MCM N-terminal domain Hid1 PF12722.7 ETO19704.1 - 0.61 8.1 6.4 0.74 7.9 6.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 ETO19704.1 - 1.7 7.1 8.4 2.2 6.7 8.4 1.1 1 0 0 1 1 1 0 Macoilin family Cyclin_N PF00134.23 ETO19707.1 - 4.5e-36 123.4 0.6 7.7e-36 122.7 0.6 1.3 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO19707.1 - 5.4e-10 39.4 1.6 8.7e-10 38.7 0.1 2.0 2 0 0 2 2 2 1 Cyclin, C-terminal domain GYF_2 PF14237.6 ETO19708.1 - 6.7e-05 22.6 0.1 0.00013 21.7 0.1 1.6 1 0 0 1 1 1 1 GYF domain 2 LAP1C PF05609.12 ETO19708.1 - 0.05 12.7 12.5 0.06 12.4 12.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Hid1 PF12722.7 ETO19708.1 - 1.9 6.5 15.3 2.3 6.2 15.3 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Exo_endo_phos PF03372.23 ETO19709.1 - 0.0032 17.0 0.0 0.0043 16.6 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family C2 PF00168.30 ETO19710.1 - 6.9e-05 23.1 0.0 0.00051 20.3 0.0 2.3 1 1 1 2 2 2 1 C2 domain Exo_endo_phos PF03372.23 ETO19710.1 - 0.0063 16.1 0.1 0.22 11.0 0.0 2.1 2 0 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family Endonuclease_5 PF04493.14 ETO19711.1 - 5.3e-16 58.9 0.0 9.1e-16 58.1 0.0 1.3 1 0 0 1 1 1 1 Endonuclease V WASH-7_C PF14746.6 ETO19712.1 - 0.011 15.4 0.6 0.02 14.6 0.6 1.4 1 0 0 1 1 1 0 WASH complex subunit 7, C-terminal Trypan_PARP PF05887.11 ETO19712.1 - 0.095 12.7 4.1 0.17 11.8 4.1 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Neur_chan_memb PF02932.16 ETO19712.1 - 1.1 9.3 4.8 1.4 8.9 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4175 PF13779.6 ETO19712.1 - 4.7 5.0 14.2 5.8 4.7 14.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) RasGAP PF00616.19 ETO19713.1 - 0.0078 15.9 1.1 0.017 14.8 1.1 1.7 1 1 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase NLRC4_HD2 PF17776.1 ETO19714.1 - 0.0032 18.0 1.5 0.048 14.2 0.1 2.7 2 0 0 2 2 2 1 NLRC4 helical domain HD2 GHD PF17834.1 ETO19715.1 - 0.038 14.0 2.6 2.9 8.0 0.3 2.4 2 0 0 2 2 2 0 Beta-sandwich domain in beta galactosidase RasGEF PF00617.19 ETO19716.1 - 1.7e-30 106.6 2.4 2.2e-29 102.9 2.4 2.5 1 1 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETO19716.1 - 6.5e-06 26.3 2.8 6.5e-06 26.3 2.8 2.3 2 0 0 2 2 2 1 RasGEF N-terminal motif CFIA_Pcf11 PF11526.8 ETO19716.1 - 0.12 12.9 12.8 0.23 12.0 4.9 2.5 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 USP8_dimer PF08969.11 ETO19716.1 - 4.1 7.6 8.7 6.4 7.0 1.9 3.1 3 0 0 3 3 3 0 USP8 dimerisation domain DUF1947 PF09183.10 ETO19718.1 - 0.0051 17.1 8.2 0.28 11.5 0.1 3.1 2 1 0 2 2 2 2 Domain of unknown function (DUF1947) HDNR PF15115.6 ETO19719.1 - 0.045 14.0 0.0 0.054 13.7 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function with conserved HDNR motif Lebercilin PF15619.6 ETO19720.1 - 0.00013 21.7 8.6 0.00016 21.4 8.6 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease MPS2 PF17060.5 ETO19720.1 - 0.0013 18.0 0.4 0.0015 17.8 0.4 1.1 1 0 0 1 1 1 1 Monopolar spindle protein 2 EMP24_GP25L PF01105.24 ETO19720.1 - 0.0056 16.6 0.4 0.0065 16.4 0.4 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD Synaptobrevin PF00957.21 ETO19720.1 - 0.0071 16.1 3.2 0.011 15.5 3.2 1.3 1 0 0 1 1 1 1 Synaptobrevin DUF4407 PF14362.6 ETO19720.1 - 0.012 15.0 4.9 0.014 14.8 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM76 PF16046.5 ETO19720.1 - 0.017 14.5 7.1 0.02 14.2 7.1 1.1 1 0 0 1 1 1 0 FAM76 protein TSC22 PF01166.18 ETO19720.1 - 0.034 14.4 2.5 0.034 14.4 2.5 1.9 1 1 1 2 2 2 0 TSC-22/dip/bun family DUF2207 PF09972.9 ETO19720.1 - 0.037 12.8 2.4 0.045 12.5 2.4 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) CAMSAP_CC1 PF17095.5 ETO19720.1 - 0.041 13.7 5.4 0.12 12.3 5.4 1.7 1 0 0 1 1 1 0 Spectrin-binding region of Ca2+-Calmodulin HXXSHH PF07586.11 ETO19720.1 - 0.049 13.2 1.1 0.056 13.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1552) DivIC PF04977.15 ETO19720.1 - 0.054 13.3 8.9 0.12 12.1 8.7 1.7 1 1 0 1 1 1 0 Septum formation initiator Atg14 PF10186.9 ETO19720.1 - 0.08 12.0 7.8 0.09 11.8 7.8 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Fungal_trans_2 PF11951.8 ETO19720.1 - 0.089 11.6 0.9 0.12 11.2 0.9 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain MCU PF04678.13 ETO19720.1 - 0.09 12.9 1.0 0.1 12.7 1.0 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter FapA PF03961.13 ETO19720.1 - 0.092 11.3 5.0 0.099 11.2 5.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIVA PF05103.13 ETO19720.1 - 0.12 12.4 8.3 0.2 11.7 8.3 1.3 1 0 0 1 1 1 0 DivIVA protein FliD_N PF02465.18 ETO19720.1 - 0.2 12.3 5.3 0.37 11.5 5.3 1.4 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF1043 PF06295.12 ETO19720.1 - 1.6 8.8 7.6 0.39 10.7 3.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) DUF2203 PF09969.9 ETO19720.1 - 2.6 8.8 6.9 0.77 10.5 4.3 1.5 2 0 0 2 2 1 0 Uncharacterized conserved protein (DUF2203) DP PF08781.10 ETO19720.1 - 7.3 6.5 11.3 1.7 8.5 8.4 1.5 2 0 0 2 2 2 0 Transcription factor DP XhlA PF10779.9 ETO19720.1 - 8.3 6.7 8.6 2.5 8.4 4.5 2.1 1 1 1 2 2 2 0 Haemolysin XhlA CDC45 PF02724.14 ETO19721.1 - 0.0026 16.1 9.0 0.003 15.9 9.0 1.3 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 ETO19721.1 - 0.0044 17.2 12.7 0.0054 16.9 12.7 1.3 1 0 0 1 1 1 1 YL1 nuclear protein Tim54 PF11711.8 ETO19721.1 - 0.04 12.7 1.1 0.044 12.6 1.1 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Myc_N PF01056.18 ETO19721.1 - 0.053 13.4 8.7 0.067 13.1 8.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region SDA1 PF05285.12 ETO19721.1 - 0.059 12.8 23.4 0.067 12.6 23.4 1.1 1 0 0 1 1 1 0 SDA1 Spore_coat_CotO PF14153.6 ETO19721.1 - 0.074 13.0 3.2 0.1 12.5 3.2 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Zip PF02535.22 ETO19721.1 - 0.094 11.9 3.2 0.088 12.0 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 ETO19721.1 - 0.2 10.6 0.1 0.26 10.2 0.1 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Nop14 PF04147.12 ETO19721.1 - 1.1 7.4 27.0 1.2 7.3 27.0 1.0 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO19721.1 - 1.3 7.7 12.2 1.4 7.6 12.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO19721.1 - 1.5 7.5 5.1 1.5 7.5 5.1 1.1 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 ETO19721.1 - 1.8 6.9 23.2 2 6.8 23.2 1.0 1 0 0 1 1 1 0 Mpp10 protein FAM60A PF15396.6 ETO19721.1 - 2 8.4 7.2 2.9 7.9 7.2 1.2 1 0 0 1 1 1 0 Protein Family FAM60A SpoIIIAH PF12685.7 ETO19721.1 - 5.5 6.8 13.4 6.3 6.6 13.4 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein Trypan_PARP PF05887.11 ETO19722.1 - 0.023 14.7 4.6 0.026 14.5 4.6 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Atrophin-1 PF03154.15 ETO19722.1 - 0.037 12.3 14.0 0.043 12.1 14.0 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 ETO19722.1 - 2.1 8.4 14.3 3.9 7.5 14.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) DUF3381 PF11861.8 ETO19722.1 - 5.3 6.8 25.4 5.9 6.7 25.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) NEMP PF10225.9 ETO19722.1 - 6.1 6.4 5.2 5.9 6.5 5.2 1.0 1 0 0 1 1 1 0 NEMP family RabGAP-TBC PF00566.18 ETO19722.1 - 9.4 5.8 9.0 11 5.7 9.0 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Glyco_hydro_3 PF00933.21 ETO19723.1 - 3.7e-18 66.0 0.0 5.6e-18 65.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 N terminal domain Glyco_hydro_3_C PF01915.22 ETO19723.1 - 3.3e-15 56.6 0.0 5e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain Beta_helix PF13229.6 ETO19724.1 - 8.3e-05 22.5 4.4 0.14 12.0 0.1 2.3 2 0 0 2 2 2 2 Right handed beta helix region Mucin PF01456.17 ETO19724.1 - 0.00075 19.5 10.0 0.0009 19.2 10.0 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Chlam_PMP PF02415.17 ETO19724.1 - 0.016 15.6 20.5 0.95 10.1 1.1 6.1 6 1 0 6 6 6 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF1478 PF07349.11 ETO19724.1 - 0.047 13.6 0.0 0.085 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1478) DUF4844 PF16133.5 ETO19724.1 - 0.079 13.5 0.0 0.19 12.3 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4844) Dicty_REP PF05086.12 ETO19724.1 - 0.41 8.6 2.8 0.48 8.4 2.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Keratin_2_head PF16208.5 ETO19726.1 - 0.082 13.0 7.5 0.13 12.3 7.5 1.3 1 0 0 1 1 1 0 Keratin type II head SpoIIIAH PF12685.7 ETO19726.1 - 0.35 10.7 14.9 0.81 9.5 14.9 1.6 1 0 0 1 1 1 0 SpoIIIAH-like protein Hid1 PF12722.7 ETO19726.1 - 3.2 5.8 17.3 4.5 5.3 17.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Laminin_II PF06009.12 ETO19727.1 - 0.0072 16.4 3.9 0.011 15.8 3.9 1.2 1 0 0 1 1 1 1 Laminin Domain II DHR10 PF18595.1 ETO19727.1 - 0.28 11.3 6.5 0.46 10.6 6.5 1.3 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain FbpA PF05833.11 ETO19727.1 - 0.3 9.8 8.2 0.075 11.8 5.2 1.4 2 0 0 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) DUF1387 PF07139.11 ETO19728.1 - 6.8 6.3 19.7 10 5.8 19.7 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1387) Ly49 PF08391.10 ETO19729.1 - 0.032 14.6 0.9 0.041 14.3 0.9 1.1 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region AIG1 PF04548.16 ETO19729.1 - 0.052 12.9 1.4 0.063 12.6 1.4 1.1 1 0 0 1 1 1 0 AIG1 family DUF4337 PF14235.6 ETO19729.1 - 5.2 7.2 10.0 6 7.0 9.3 1.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Glyco_transf_92 PF01697.27 ETO19730.1 - 9.6e-05 22.1 2.9 9.6e-05 22.1 2.9 3.4 1 1 1 3 3 3 2 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO19730.1 - 0.0096 16.4 0.7 0.0096 16.4 0.7 2.3 3 0 0 3 3 3 1 Glycosyl transferase family 2 NST1 PF13945.6 ETO19730.1 - 0.18 11.9 10.7 0.24 11.5 10.7 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Sld7_C PF18596.1 ETO19730.1 - 0.24 11.6 0.9 0.49 10.6 0.9 1.8 1 1 0 1 1 1 0 Sld7 C-terminal domain PDZ PF00595.24 ETO19731.1 - 0.0046 17.3 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO19731.1 - 0.0059 16.4 0.0 0.011 15.6 0.0 1.4 1 0 0 1 1 1 1 PDZ domain DUF3394 PF11874.8 ETO19731.1 - 0.062 13.0 0.3 0.12 12.0 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3394) Ycf1 PF05758.12 ETO19731.1 - 0.57 8.0 7.5 1.1 7.0 7.5 1.4 1 0 0 1 1 1 0 Ycf1 DUF2281 PF10047.9 ETO19731.1 - 1.8 9.3 6.9 1.1 10.1 1.4 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2281) RXT2_N PF08595.11 ETO19731.1 - 7.5 6.6 27.3 0.2 11.7 11.3 3.3 3 0 0 3 3 3 0 RXT2-like, N-terminal RNase_T PF00929.24 ETO19733.1 - 0.025 15.1 0.9 0.12 12.9 0.1 2.2 2 1 1 3 3 3 0 Exonuclease DNA_pol_A_exo1 PF01612.20 ETO19733.1 - 0.047 13.4 1.0 0.11 12.3 0.2 1.9 2 0 0 2 2 2 0 3'-5' exonuclease DUF5051 PF16473.5 ETO19733.1 - 0.087 12.8 0.2 1.9 8.5 0.0 2.1 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like TPP_enzyme_C PF02775.21 ETO19734.1 - 6.2e-23 81.3 0.0 1.5e-22 80.0 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain TPP_enzyme_M PF00205.22 ETO19734.1 - 5.7e-16 58.5 0.0 1.4e-15 57.2 0.0 1.7 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, central domain TPP_enzyme_N PF02776.18 ETO19734.1 - 1.7e-15 57.1 0.1 1.2e-14 54.3 0.1 2.2 2 0 0 2 2 2 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain CO_dh PF02552.16 ETO19734.1 - 0.032 14.0 2.0 0.04 13.7 0.1 2.1 2 1 0 2 2 2 0 CO dehydrogenase beta subunit/acetyl-CoA synthase epsilon subunit zf-TRAF PF02176.18 ETO19735.1 - 0.00018 22.1 2.5 0.00018 22.1 2.5 2.5 2 0 0 2 2 2 1 TRAF-type zinc finger Exonuc_VII_L PF02601.15 ETO19735.1 - 0.15 11.6 8.6 0.21 11.1 8.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-RING-like PF08746.11 ETO19735.1 - 0.15 12.4 3.8 0.27 11.6 0.0 3.2 3 1 1 4 4 4 0 RING-like domain DUF5362 PF17319.2 ETO19735.1 - 0.37 10.7 2.1 5.1 7.0 0.1 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5362) FapA PF03961.13 ETO19735.1 - 0.97 8.0 18.7 1.4 7.5 18.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 ETO19735.1 - 6.7 7.4 26.6 2.8 8.6 3.6 2.7 1 1 1 2 2 2 0 Initiation control protein YabA MutS_IV PF05190.18 ETO19737.1 - 0.099 13.0 3.6 8.1 6.9 0.1 2.9 3 0 0 3 3 3 0 MutS family domain IV PTPRCAP PF15713.5 ETO19737.1 - 0.63 10.3 9.2 0.12 12.7 1.6 2.3 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated NOA36 PF06524.12 ETO19737.1 - 1.6 7.9 10.1 4.1 6.6 10.1 1.6 1 0 0 1 1 1 0 NOA36 protein YcxB PF14317.6 ETO19739.1 - 1.2 8.9 4.8 31 4.4 4.8 2.5 1 1 0 1 1 1 0 YcxB-like protein Menin PF05053.13 ETO19739.1 - 1.3 7.3 6.4 1.3 7.3 6.4 1.0 1 0 0 1 1 1 0 Menin DUF2868 PF11067.8 ETO19740.1 - 0.28 10.7 2.5 0.36 10.3 2.5 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF2868) FYDLN_acid PF09538.10 ETO19740.1 - 3.1 8.5 12.4 2.4 8.9 8.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) zf-HC5HC2H_2 PF13832.6 ETO19741.1 - 3.6e-13 49.6 28.0 1.2e-07 31.8 3.5 4.4 4 0 0 4 4 4 3 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO19741.1 - 5.2e-08 33.0 5.0 5.2e-08 33.0 5.0 4.7 4 1 1 5 5 5 2 PHD-like zinc-binding domain PHD_2 PF13831.6 ETO19741.1 - 0.00014 21.4 12.1 0.00014 21.4 12.1 3.3 4 0 0 4 4 4 1 PHD-finger PHD PF00628.29 ETO19741.1 - 0.00032 20.5 14.4 0.00032 20.5 14.4 4.3 5 0 0 5 5 5 2 PHD-finger Cytochrome_CBB3 PF13442.6 ETO19742.1 - 0.013 15.8 0.1 0.022 15.0 0.1 1.3 1 0 0 1 1 1 0 Cytochrome C oxidase, cbb3-type, subunit III 60KD_IMP PF02096.20 ETO19742.1 - 0.31 10.9 8.1 0.92 9.4 3.0 2.6 1 1 1 2 2 2 0 60Kd inner membrane protein RCC1 PF00415.18 ETO19743.1 - 3.3e-22 78.8 2.4 7.5e-10 39.3 0.8 3.6 3 0 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO19743.1 - 1.3e-14 53.5 8.8 2.4e-07 30.3 0.6 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Nucleotid_trans PF03407.16 ETO19745.1 - 3.9e-16 59.7 0.1 9.5e-16 58.4 0.0 1.6 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase S_4TM PF18159.1 ETO19746.1 - 0.012 14.9 0.7 0.017 14.4 0.7 1.1 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain LapA_dom PF06305.11 ETO19746.1 - 0.014 15.2 0.1 0.028 14.2 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain DUF2681 PF10883.8 ETO19746.1 - 0.018 15.4 0.7 0.018 15.4 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Shisa PF13908.6 ETO19746.1 - 0.018 15.3 0.6 0.02 15.1 0.6 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator SARAF PF06682.12 ETO19746.1 - 0.062 12.9 0.4 0.089 12.4 0.4 1.3 1 1 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Afi1 PF07792.12 ETO19747.1 - 1.2 9.6 6.9 1.8 9.1 6.9 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 ETO19747.1 - 1.6 7.0 6.1 1.8 6.8 6.1 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO19747.1 - 5.2 5.0 9.1 6.7 4.7 9.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi MCM_N PF14551.6 ETO19748.1 - 0.06 13.9 0.4 0.12 12.9 0.4 1.5 1 0 0 1 1 1 0 MCM N-terminal domain DUF4639 PF15479.6 ETO19748.1 - 0.58 9.0 5.1 0.75 8.7 5.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) VPS9 PF02204.18 ETO19750.1 - 2.1e-13 50.4 0.4 2.4e-11 43.8 0.0 2.4 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain CAP_GLY PF01302.25 ETO19750.1 - 5.6e-13 48.7 0.4 9.1e-13 48.0 0.4 1.3 1 0 0 1 1 1 1 CAP-Gly domain DUF3145 PF11343.8 ETO19750.1 - 0.015 14.8 0.0 0.03 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) EF-hand_7 PF13499.6 ETO19751.1 - 0.00045 20.6 2.3 0.004 17.6 2.3 2.1 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO19751.1 - 0.0028 17.4 1.6 0.8 9.8 0.8 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO19751.1 - 0.0038 16.7 2.8 0.33 10.6 0.0 2.5 2 0 0 2 2 2 2 EF hand DUF2433 PF10360.9 ETO19751.1 - 0.014 15.5 1.2 0.022 14.9 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2433) Lipase_GDSL PF00657.22 ETO19751.1 - 0.028 14.4 0.3 0.034 14.1 0.3 1.1 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase EF-hand_8 PF13833.6 ETO19751.1 - 0.25 11.2 2.1 7.7 6.5 0.7 2.2 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_4 PF12763.7 ETO19751.1 - 0.43 10.5 3.7 0.41 10.6 1.9 1.9 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand AAA_9 PF12781.7 ETO19752.1 - 3.3e-28 98.3 0.0 3.3e-28 98.3 0.0 3.5 3 1 1 4 4 3 1 ATP-binding dynein motor region MT PF12777.7 ETO19752.1 - 5e-23 81.7 10.9 7.1e-23 81.2 10.9 1.1 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Taxilin PF09728.9 ETO19752.1 - 0.00053 19.3 7.6 0.00053 19.3 7.6 2.3 2 0 0 2 2 2 1 Myosin-like coiled-coil protein DUF2968 PF11180.8 ETO19752.1 - 0.016 14.9 19.9 0.18 11.4 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) MecA_N PF05223.11 ETO19752.1 - 0.041 14.1 1.6 0.14 12.4 1.6 1.9 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain ERM PF00769.19 ETO19752.1 - 0.055 13.3 20.0 0.55 10.0 10.9 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family ANAPC5 PF12862.7 ETO19752.1 - 0.11 12.6 1.9 0.43 10.7 0.2 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 5 Filament PF00038.21 ETO19752.1 - 0.35 10.4 23.3 0.59 9.7 3.2 2.5 2 0 0 2 2 2 0 Intermediate filament protein Laminin_II PF06009.12 ETO19752.1 - 0.4 10.7 22.7 0.11 12.5 4.2 2.9 2 0 0 2 2 2 0 Laminin Domain II L31 PF09784.9 ETO19752.1 - 0.6 10.6 7.2 1.1 9.7 2.5 2.9 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L31 DUF3450 PF11932.8 ETO19752.1 - 1.9 7.8 24.5 0.46 9.8 4.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) HMMR_N PF15905.5 ETO19752.1 - 2.1 7.8 32.0 2.4 7.5 17.2 2.3 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF745 PF05335.13 ETO19752.1 - 2.1 8.0 24.6 0.76 9.5 2.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF4201 PF13870.6 ETO19752.1 - 2.4 7.9 30.1 0.069 12.9 7.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4201) DUF1664 PF07889.12 ETO19752.1 - 3.4 7.7 21.7 1.3 9.1 2.7 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ETO19752.1 - 4.9 7.3 26.2 4.2 7.5 7.6 2.5 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) Syntaxin-6_N PF09177.11 ETO19752.1 - 5.5 7.6 17.2 0.67 10.5 6.3 3.0 2 1 0 2 2 2 0 Syntaxin 6, N-terminal Exonuc_VII_L PF02601.15 ETO19752.1 - 5.8 6.4 21.2 4.1 6.9 4.6 2.4 2 0 0 2 2 2 0 Exonuclease VII, large subunit Spc7 PF08317.11 ETO19752.1 - 7.8 5.3 32.6 1.1 8.0 9.2 2.5 2 0 0 2 2 2 0 Spc7 kinetochore protein EzrA PF06160.12 ETO19752.1 - 8.6 4.4 29.7 0.3 9.2 7.2 3.0 1 1 1 3 3 3 0 Septation ring formation regulator, EzrA AAA_7 PF12775.7 ETO19754.1 - 2e-17 63.3 0.6 3.1e-17 62.7 0.6 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_22 PF13401.6 ETO19754.1 - 0.0032 17.7 0.1 0.015 15.6 0.0 2.0 2 1 0 2 2 2 1 AAA domain Sigma54_activat PF00158.26 ETO19754.1 - 0.0059 16.3 0.0 0.0096 15.6 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_16 PF13191.6 ETO19754.1 - 0.046 14.1 0.0 0.062 13.7 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ETO19754.1 - 0.058 13.4 0.0 0.18 11.8 0.0 1.8 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) Sec7_N PF12783.7 ETO19755.1 - 0.008 16.1 0.1 0.011 15.6 0.1 1.3 1 0 0 1 1 1 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF739 PF05339.11 ETO19755.1 - 0.097 12.8 0.1 7.6 6.8 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF739) G-alpha PF00503.20 ETO19757.1 - 5.3e-53 180.4 3.6 6.1e-53 180.2 3.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO19757.1 - 1.2e-09 37.9 0.2 2.4e-09 36.9 0.2 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family MCU PF04678.13 ETO19758.1 - 0.47 10.5 3.2 0.97 9.5 2.9 1.8 1 1 0 1 1 1 0 Mitochondrial calcium uniporter DUF4637 PF15470.6 ETO19758.1 - 0.84 9.3 9.8 0.77 9.5 5.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) EMP24_GP25L PF01105.24 ETO19759.1 - 0.014 15.4 6.7 0.044 13.7 0.1 2.6 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD CLZ PF16526.5 ETO19759.1 - 0.19 12.1 13.1 0.29 11.5 4.2 2.7 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels UPF0184 PF03670.13 ETO19759.1 - 0.28 11.6 2.4 16 5.9 0.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0184) DUF4600 PF15372.6 ETO19759.1 - 6.3 7.2 15.7 3.9 7.9 4.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) DUF1285 PF06938.11 ETO19760.1 - 0.053 13.5 0.7 1.7 8.7 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1285) NAC PF01849.18 ETO19762.1 - 1.1e-18 66.9 0.5 3.1e-18 65.5 0.2 2.0 2 0 0 2 2 2 1 NAC domain DNA_ligase_A_C PF04679.15 ETO19762.1 - 0.076 13.6 0.5 0.18 12.4 0.0 1.8 2 1 0 2 2 2 0 ATP dependent DNA ligase C terminal region HI0933_like PF03486.14 ETO19762.1 - 0.083 11.6 3.0 0.067 11.9 1.0 1.7 1 1 1 2 2 2 0 HI0933-like protein Macscav_rec PF03523.13 ETO19762.1 - 0.089 12.7 0.2 0.31 10.9 0.2 1.9 1 0 0 1 1 1 0 Macrophage scavenger receptor zf-RanBP PF00641.18 ETO19764.1 - 4e-06 26.0 11.2 0.0057 15.9 1.6 3.2 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others UFD1 PF03152.14 ETO19764.1 - 0.016 14.7 0.1 0.03 13.8 0.1 1.5 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 zf-RING_7 PF02591.15 ETO19764.1 - 0.35 11.1 3.5 7 6.9 0.0 3.4 3 0 0 3 3 3 0 C4-type zinc ribbon domain zf_UBZ PF18439.1 ETO19764.1 - 0.59 9.8 19.4 3.3 7.4 0.5 5.7 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger CAP_GLY PF01302.25 ETO19765.1 - 6.9e-26 90.1 5.2 3.1e-13 49.5 0.1 2.7 2 0 0 2 2 2 2 CAP-Gly domain DUF1287 PF06940.11 ETO19765.1 - 0.007 16.0 0.3 1.9 8.2 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF1287) ubiquitin PF00240.23 ETO19767.1 - 2.1e-06 27.4 0.0 2.1e-06 27.4 0.0 2.0 2 0 0 2 2 1 1 Ubiquitin family DUF2722 PF10846.8 ETO19767.1 - 0.0004 19.5 1.3 0.0004 19.5 1.3 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Pex14_N PF04695.13 ETO19767.1 - 0.001 19.8 0.9 0.0015 19.2 0.9 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Dpy19 PF10034.9 ETO19767.1 - 0.0026 16.1 2.1 0.004 15.4 2.1 1.2 1 0 0 1 1 1 1 Q-cell neuroblast polarisation FA_desaturase PF00487.24 ETO19767.1 - 0.0067 16.3 1.1 0.011 15.6 1.1 1.3 1 0 0 1 1 1 1 Fatty acid desaturase DUF2417 PF10329.9 ETO19767.1 - 0.007 15.8 2.5 0.011 15.2 2.5 1.2 1 0 0 1 1 1 1 Region of unknown function (DUF2417) Rad60-SLD PF11976.8 ETO19767.1 - 0.015 15.1 0.0 0.015 15.1 0.0 2.8 3 1 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like Orf78 PF06024.12 ETO19767.1 - 0.028 14.7 0.1 0.028 14.7 0.1 3.3 3 1 0 3 3 2 0 Orf78 (ac78) FAM60A PF15396.6 ETO19767.1 - 0.04 13.9 4.1 0.051 13.6 4.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Rtf2 PF04641.12 ETO19767.1 - 0.83 9.0 7.6 1.1 8.6 7.6 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger Androgen_recep PF02166.16 ETO19767.1 - 1.7 7.4 12.6 2.2 7.0 12.6 1.2 1 0 0 1 1 1 0 Androgen receptor UFD1 PF03152.14 ETO19768.1 - 3.2e-18 65.8 0.0 1.8e-08 34.1 0.0 2.2 2 0 0 2 2 2 2 Ubiquitin fusion degradation protein UFD1 Pkinase PF00069.25 ETO19772.1 - 0.00041 19.8 0.0 0.00049 19.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO19773.1 - 8e-30 104.1 0.3 1.7e-29 103.0 0.3 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19773.1 - 2.6e-08 33.5 0.1 4.3e-08 32.7 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ETO19773.1 - 6.4e-05 22.7 0.3 0.0016 18.1 0.1 2.2 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ETO19773.1 - 0.00076 19.5 0.0 0.0012 18.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO19773.1 - 0.0088 15.4 0.1 0.016 14.6 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YL1 PF05764.13 ETO19776.1 - 0.0078 16.4 10.5 0.015 15.4 10.5 1.5 1 1 0 1 1 1 1 YL1 nuclear protein zf-C3HC4_3 PF13920.6 ETO19776.1 - 0.054 13.4 12.8 0.12 12.3 12.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO19776.1 - 0.077 13.3 15.0 0.21 12.0 15.0 1.8 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO19776.1 - 0.75 9.7 13.1 2 8.3 13.1 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Cwf_Cwc_15 PF04889.12 ETO19776.1 - 0.79 9.4 20.5 0.5 10.1 13.6 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein zf-RING_5 PF14634.6 ETO19776.1 - 1.7 8.7 13.0 4.2 7.4 13.0 1.8 1 0 0 1 1 1 0 zinc-RING finger domain GCIP PF13324.6 ETO19776.1 - 2.1 7.9 9.0 3.6 7.1 9.0 1.4 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF4692 PF15763.5 ETO19776.1 - 4.3 7.8 11.3 0.27 11.7 2.2 2.4 3 0 0 3 3 3 0 Regulator of human erythroid cell expansion (RHEX) Sigma70_ner PF04546.13 ETO19776.1 - 9.5 6.0 12.5 19 5.1 12.5 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF3439 PF11921.8 ETO19778.1 - 0.093 12.7 4.1 0.17 11.9 4.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ACDC PF14733.6 ETO19778.1 - 0.15 12.4 0.1 0.15 12.4 0.1 1.7 2 0 0 2 2 2 0 AP2-coincident C-terminal SRP19 PF01922.17 ETO19779.1 - 4.1e-06 27.7 0.0 4.1e-06 27.7 0.0 2.2 2 1 0 2 2 2 1 SRP19 protein Pns11_12 PF17464.2 ETO19779.1 - 0.054 13.2 6.2 0.061 13.0 6.2 1.2 1 0 0 1 1 1 0 Non-structural protein 11 and 12 V_ATPase_I PF01496.19 ETO19779.1 - 0.21 9.5 3.1 0.21 9.5 3.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MAP17 PF15807.5 ETO19779.1 - 0.28 11.4 5.4 0.36 11.1 5.4 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2570 PF10828.8 ETO19779.1 - 1.2 9.0 10.6 1.7 8.5 10.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) Presenilin PF01080.17 ETO19779.1 - 3.3 6.4 5.1 3.3 6.4 5.1 1.0 1 0 0 1 1 1 0 Presenilin DUF3959 PF13105.6 ETO19779.1 - 4.6 6.7 10.0 5.3 6.5 10.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Connexin PF00029.19 ETO19779.1 - 5.6 6.6 8.2 6.3 6.5 8.2 1.1 1 0 0 1 1 1 0 Connexin DEP PF00610.21 ETO19780.1 - 3.6e-40 135.9 0.3 1.3e-19 70.0 0.0 2.3 2 0 0 2 2 2 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GSHPx PF00255.19 ETO19781.1 - 2.9e-36 123.3 0.1 6.2e-36 122.3 0.1 1.6 1 0 0 1 1 1 1 Glutathione peroxidase Redoxin PF08534.10 ETO19781.1 - 0.0079 15.9 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Redoxin DUF1088 PF06469.11 ETO19781.1 - 0.091 12.4 1.1 0.17 11.5 1.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1088) Pesticin PF16754.5 ETO19783.1 - 9 6.2 9.4 13 5.7 0.8 2.6 2 1 0 2 2 2 0 Bacterial toxin homologue of phage lysozyme, C-term Uds1 PF15456.6 ETO19785.1 - 0.064 13.4 1.7 0.22 11.7 0.2 2.6 2 0 0 2 2 2 0 Up-regulated During Septation DUF4298 PF14131.6 ETO19785.1 - 5 7.2 10.8 11 6.1 0.2 4.9 4 1 1 5 5 5 0 Domain of unknown function (DUF4298) Vert_HS_TF PF06546.11 ETO19786.1 - 0.003 17.3 0.6 0.0058 16.3 0.6 1.4 1 0 0 1 1 1 1 Vertebrate heat shock transcription factor HMw1_D2 PF18254.1 ETO19786.1 - 0.032 14.6 0.8 0.13 12.6 0.2 2.4 2 1 1 3 3 3 0 HMW1 domain 2 SpoIIP PF07454.11 ETO19786.1 - 0.16 11.4 9.0 0.28 10.6 9.0 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 ETO19786.1 - 0.44 10.2 4.2 0.83 9.3 4.2 1.4 1 0 0 1 1 1 0 FAM176 family TLP-20 PF06088.11 ETO19786.1 - 4.7 7.1 13.1 1.4 8.8 10.1 1.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PUB PF09409.10 ETO19788.1 - 0.00033 20.5 0.3 0.00097 19.0 0.3 1.9 1 1 0 1 1 1 1 PUB domain SWIB PF02201.18 ETO19788.1 - 0.016 15.1 0.2 0.036 13.9 0.2 1.6 1 0 0 1 1 1 0 SWIB/MDM2 domain INTS5_C PF14838.6 ETO19788.1 - 0.071 11.7 0.3 0.1 11.2 0.3 1.1 1 0 0 1 1 1 0 Integrator complex subunit 5 C-terminus DHQ_synthase PF01761.20 ETO19788.1 - 0.074 12.2 0.0 0.1 11.7 0.0 1.3 1 0 0 1 1 1 0 3-dehydroquinate synthase CW_binding_1 PF01473.20 ETO19788.1 - 0.67 10.4 9.1 8.6 6.9 2.4 2.7 2 0 0 2 2 2 0 Putative cell wall binding repeat PXA PF02194.15 ETO19789.1 - 4.1e-08 33.4 0.1 6.8e-08 32.7 0.1 1.4 1 0 0 1 1 1 1 PXA domain ATG101 PF07855.12 ETO19790.1 - 0.0055 16.7 0.3 0.022 14.8 0.0 2.0 2 0 0 2 2 2 1 Autophagy-related protein 101 CAP_GLY PF01302.25 ETO19790.1 - 0.14 12.2 0.1 1 9.4 0.1 2.2 2 0 0 2 2 2 0 CAP-Gly domain DUF3761 PF12587.8 ETO19790.1 - 0.18 12.3 6.2 0.048 14.1 2.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3761) Ofd1_CTDD PF10637.9 ETO19791.1 - 3.9e-12 46.1 2.0 6.4e-12 45.4 2.0 1.3 1 0 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term AAA_lid_11 PF18198.1 ETO19791.1 - 0.00046 20.0 0.2 0.44 10.4 0.0 2.1 2 0 0 2 2 2 2 Dynein heavy chain AAA lid domain Asp PF00026.23 ETO19792.1 - 5e-20 72.2 0.0 5.8e-20 71.9 0.0 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease Asp PF00026.23 ETO19793.1 - 4.2e-58 197.2 0.9 5e-58 197.0 0.9 1.0 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO19793.1 - 1e-12 48.6 1.4 6.1e-11 42.9 1.4 2.4 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal 2OG-FeII_Oxy_4 PF13661.6 ETO19794.1 - 2.1e-25 89.2 0.0 2.6e-25 88.9 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_3 PF13640.6 ETO19794.1 - 3.5e-16 59.9 0.0 4.4e-16 59.6 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ofd1_CTDD PF10637.9 ETO19794.1 - 2.2e-08 33.8 0.0 2.4e-08 33.6 0.0 1.1 1 0 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term WD40 PF00400.32 ETO19795.1 - 1.4e-23 82.7 5.6 4.9e-06 27.2 0.1 7.2 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19795.1 - 3e-11 43.5 2.9 8.8e-06 25.9 0.1 5.0 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO19795.1 - 0.00014 21.3 0.0 0.52 9.6 0.0 2.5 2 1 0 2 2 2 2 WD40-like domain Rav1p_C PF12234.8 ETO19795.1 - 0.0072 14.8 0.0 0.013 14.0 0.0 1.3 1 0 0 1 1 1 1 RAVE protein 1 C terminal Me-amine-dh_H PF06433.11 ETO19795.1 - 0.028 13.3 0.1 0.11 11.4 0.0 1.9 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) NHL PF01436.21 ETO19795.1 - 0.031 14.3 1.5 0.5 10.5 0.2 3.0 3 0 0 3 3 3 0 NHL repeat DUF3977 PF13122.6 ETO19795.1 - 0.079 13.2 1.7 0.8 10.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3977) U-box PF04564.15 ETO19796.1 - 1e-08 35.2 0.2 6e-08 32.8 0.2 1.9 1 1 0 1 1 1 1 U-box domain Orf78 PF06024.12 ETO19797.1 - 0.031 14.6 3.9 0.031 14.6 3.9 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO19797.1 - 0.26 11.8 19.4 2.5 8.7 13.3 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain dCache_1 PF02743.18 ETO19798.1 - 0.016 15.0 0.7 0.54 10.0 0.7 2.6 1 1 0 1 1 1 0 Cache domain YqaJ PF09588.10 ETO19798.1 - 0.14 12.3 0.0 0.38 10.9 0.0 1.7 2 0 0 2 2 2 0 YqaJ-like viral recombinase domain Ion_trans PF00520.31 ETO19799.1 - 6.1e-11 42.0 45.7 3.9e-05 23.0 7.8 5.4 4 1 1 5 5 5 2 Ion transport protein EF-hand_1 PF00036.32 ETO19799.1 - 0.00014 21.1 0.2 0.035 13.7 0.0 2.9 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 ETO19799.1 - 0.00019 20.8 0.5 0.0012 18.3 0.0 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO19799.1 - 0.0041 16.9 0.5 0.55 10.3 0.0 2.9 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ETO19799.1 - 0.026 15.0 3.6 0.059 13.8 0.8 2.7 2 1 1 3 3 3 0 EF-hand domain pair DUF5436 PF17504.2 ETO19799.1 - 0.063 13.6 0.8 1 9.7 0.1 3.0 2 0 0 2 2 2 0 Family of unknown function (DUF5436) EF-hand_8 PF13833.6 ETO19799.1 - 0.13 12.1 0.2 4.4 7.2 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain pair Peptidase_S49_N PF08496.10 ETO19799.1 - 0.27 11.3 10.8 0.054 13.6 1.7 2.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal NINJA_B PF16136.5 ETO19799.1 - 3.1 8.2 8.8 0.48 10.8 4.1 2.0 2 0 0 2 2 2 0 Putative nuclear localisation signal DUF4349 PF14257.6 ETO19800.1 - 1.4 8.3 5.2 1.6 8.1 3.7 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) CCDC-167 PF15188.6 ETO19800.1 - 1.9 8.9 12.4 2.2 8.7 2.0 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 SWI-SNF_Ssr4 PF08549.10 ETO19801.1 - 1.2 7.7 18.5 1.6 7.2 18.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) CCSAP PF15748.5 ETO19801.1 - 3.9 7.6 18.9 6.6 6.8 18.9 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Apc15p PF05841.11 ETO19801.1 - 6.3 7.6 18.2 1.2 9.9 11.1 2.3 2 0 0 2 2 2 0 Apc15p protein Prenylcys_lyase PF07156.14 ETO19802.1 - 1.2e-46 159.5 0.7 3.7e-46 157.9 0.7 1.6 1 1 0 1 1 1 1 Prenylcysteine lyase Amino_oxidase PF01593.24 ETO19802.1 - 3.2e-07 30.0 0.4 8.7e-07 28.6 0.4 1.5 1 1 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 ETO19802.1 - 0.021 14.1 0.0 0.056 12.7 0.0 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO19802.1 - 0.044 14.0 0.0 0.17 12.1 0.0 1.9 2 0 0 2 2 2 0 NAD(P)-binding Rossmann-like domain RCC1_2 PF13540.6 ETO19803.1 - 3.1e-05 23.6 1.2 0.11 12.3 0.1 2.9 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO19803.1 - 0.0014 19.2 0.4 0.0014 19.2 0.4 3.8 4 1 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO19804.1 - 0.12 13.0 0.0 0.42 11.3 0.0 1.9 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat CPSF_A PF03178.15 ETO19806.1 - 0.00029 20.3 0.1 0.00047 19.6 0.1 1.2 1 0 0 1 1 1 1 CPSF A subunit region Kelch_4 PF13418.6 ETO19806.1 - 0.00054 19.9 0.1 0.0019 18.2 0.1 1.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO19806.1 - 0.019 14.5 0.2 0.29 10.8 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO19806.1 - 0.026 14.8 0.7 4.9 7.6 0.1 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO19806.1 - 0.03 14.3 1.6 2.8 8.0 0.1 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO19806.1 - 0.16 12.0 0.3 1.1 9.3 0.0 2.6 1 1 1 2 2 2 0 Kelch motif Ead_Ea22 PF13935.6 ETO19807.1 - 0.0053 17.4 0.7 0.0072 17.0 0.7 1.4 1 1 0 1 1 1 1 Ead/Ea22-like protein VPS9 PF02204.18 ETO19808.1 - 2.7e-09 37.2 0.1 5.9e-06 26.4 0.0 2.3 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain DNA_gyraseB PF00204.25 ETO19808.1 - 0.13 11.7 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 DNA gyrase B IQ PF00612.27 ETO19808.1 - 0.22 11.4 0.2 0.39 10.6 0.2 1.4 1 0 0 1 1 1 0 IQ calmodulin-binding motif RGS PF00615.19 ETO19810.1 - 4e-05 23.9 0.0 8.5e-05 22.8 0.0 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain BUD22 PF09073.10 ETO19810.1 - 0.0015 17.9 21.3 0.0021 17.5 21.3 1.2 1 0 0 1 1 1 1 BUD22 Tub_N PF16322.5 ETO19810.1 - 0.02 15.3 18.1 0.27 11.6 13.6 2.3 2 0 0 2 2 2 0 Tubby N-terminal DUF2956 PF11169.8 ETO19810.1 - 0.5 10.6 14.0 1.1 9.5 11.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) DUF4175 PF13779.6 ETO19810.1 - 1.1 7.1 12.9 1.6 6.5 12.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Nop14 PF04147.12 ETO19810.1 - 1.5 6.9 27.5 2.2 6.4 27.5 1.2 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO19810.1 - 2.1 7.0 12.7 3.4 6.3 12.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DctQ PF04290.12 ETO19810.1 - 2.6 8.0 7.9 0.29 11.0 2.7 2.0 2 0 0 2 2 2 0 Tripartite ATP-independent periplasmic transporters, DctQ component SLC12 PF03522.15 ETO19810.1 - 3.5 6.6 11.0 5.3 6.0 11.0 1.4 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO19810.1 - 4.4 5.5 19.4 6.2 5.0 19.4 1.2 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 ETO19812.1 - 0.13 12.7 16.1 0.28 11.6 3.8 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CCDC106 PF15794.5 ETO19812.1 - 0.73 9.5 9.1 0.41 10.3 5.4 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 FAM176 PF14851.6 ETO19812.1 - 4 7.1 11.7 3.5 7.3 3.3 2.5 2 0 0 2 2 2 0 FAM176 family DUF3245 PF11595.8 ETO19812.1 - 4.9 7.6 20.2 2.9 8.4 7.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) DUF4598 PF15370.6 ETO19812.1 - 5.7 7.4 13.2 13 6.4 4.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4598) Pkinase_Tyr PF07714.17 ETO19813.1 - 1.6e-12 47.3 0.3 1.6e-12 47.3 0.3 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ETO19813.1 - 3.3e-06 26.6 0.1 3.3e-06 26.6 0.1 1.7 2 0 0 2 2 2 1 Protein kinase domain DUF2722 PF10846.8 ETO19813.1 - 0.00098 18.2 7.9 0.00098 18.2 7.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) Androgen_recep PF02166.16 ETO19813.1 - 8.6 5.1 20.3 12 4.6 20.3 1.3 1 0 0 1 1 1 0 Androgen receptor Pex14_N PF04695.13 ETO19813.1 - 9.7 6.8 13.4 8.5 7.0 10.8 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region GEMIN8 PF15348.6 ETO19814.1 - 0.00023 21.6 7.5 0.00023 21.6 7.5 2.9 1 1 1 2 2 2 1 Gemini of Cajal bodies-associated protein 8 LAP1C PF05609.12 ETO19814.1 - 2 7.4 31.0 2.4 7.2 31.0 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 ETO19814.1 - 8 3.4 22.7 8.9 3.3 22.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SMYLE_N PF18615.1 ETO19815.1 - 6.5 6.2 8.3 8.8 5.8 8.3 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain SOBP PF15279.6 ETO19815.1 - 7.7 7.0 9.5 11 6.5 9.5 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein CST-I PF06002.12 ETO19817.1 - 0.067 12.9 0.1 0.096 12.4 0.1 1.2 1 0 0 1 1 1 0 Alpha-2,3-sialyltransferase (CST-I) ZZ PF00569.17 ETO19818.1 - 3.8e-05 23.4 5.7 0.00017 21.3 5.7 2.2 1 0 0 1 1 1 1 Zinc finger, ZZ type Merozoite_SPAM PF07133.11 ETO19819.1 - 0.0012 18.8 16.5 0.0017 18.4 16.5 1.2 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) RNA_pol_3_Rpc31 PF11705.8 ETO19819.1 - 0.0013 19.0 9.6 0.0013 19.0 9.6 1.7 2 0 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 Trypan_PARP PF05887.11 ETO19819.1 - 0.013 15.5 6.9 0.013 15.5 6.9 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) CDC45 PF02724.14 ETO19819.1 - 0.023 13.0 14.1 0.027 12.8 14.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Tau95_N PF17682.1 ETO19819.1 - 0.64 10.2 5.1 1.4 9.1 5.0 1.8 1 1 0 1 1 1 0 Tau95 Triple barrel domain COPI_C PF06957.11 ETO19819.1 - 1.2 7.8 8.5 1.5 7.5 8.5 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus TRAP_alpha PF03896.16 ETO19819.1 - 6 6.0 8.8 8.7 5.5 8.8 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Tetraspanin PF00335.20 ETO19821.1 - 0.00011 22.1 0.0 0.0079 15.9 0.0 2.2 2 0 0 2 2 2 1 Tetraspanin family PspB PF06667.12 ETO19821.1 - 0.0059 16.6 0.0 0.27 11.3 0.0 2.3 2 0 0 2 2 2 1 Phage shock protein B DUF4381 PF14316.6 ETO19821.1 - 0.069 13.4 0.0 0.23 11.7 0.0 1.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) DUF5058 PF16481.5 ETO19821.1 - 0.12 12.0 0.1 1.4 8.6 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF5058) Ctr PF04145.15 ETO19821.1 - 0.98 10.0 5.2 5.8 7.5 0.4 2.9 2 1 1 3 3 3 0 Ctr copper transporter family DUF4834 PF16118.5 ETO19821.1 - 1.3 10.0 0.0 1.3 10.0 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) FAM199X PF15814.5 ETO19822.1 - 6 5.8 9.8 12 4.8 9.8 1.5 1 0 0 1 1 1 0 Protein family FAM199X GPCR_chapero_1 PF11904.8 ETO19823.1 - 1.6e-05 24.5 0.5 1.6e-05 24.5 0.5 1.6 2 0 0 2 2 2 1 GPCR-chaperone Ank_2 PF12796.7 ETO19823.1 - 0.03 14.9 0.0 0.062 13.9 0.0 1.5 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) WASH-7_N PF14745.6 ETO19824.1 - 2.3e-20 72.6 0.6 3.1e-20 72.2 0.6 1.1 1 0 0 1 1 1 1 WASH complex subunit 7, N-terminal Not3 PF04065.15 ETO19824.1 - 0.13 11.7 4.5 0.25 10.7 1.2 2.1 1 1 1 2 2 2 0 Not1 N-terminal domain, CCR4-Not complex component DOCK_N PF16172.5 ETO19825.1 - 0.026 13.4 0.1 0.043 12.7 0.1 1.3 1 0 0 1 1 1 0 DOCK N-terminus Halogen_Hydrol PF10112.9 ETO19827.1 - 0.021 14.8 0.1 0.056 13.5 0.0 1.7 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein SKA2 PF16740.5 ETO19827.1 - 0.49 10.2 6.4 0.69 9.7 2.6 2.6 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 ERM PF00769.19 ETO19828.1 - 0.0023 17.8 8.0 0.003 17.4 8.0 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Spc7 PF08317.11 ETO19828.1 - 0.0076 15.2 12.7 0.0093 14.9 12.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF1198 PF06711.11 ETO19828.1 - 0.066 13.3 1.3 0.24 11.5 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1198) GAS PF13851.6 ETO19828.1 - 0.087 12.2 18.3 0.24 10.7 18.4 1.7 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding Gemini_AL1 PF00799.20 ETO19828.1 - 0.091 13.1 2.1 0.19 12.1 0.9 2.1 1 1 1 2 2 2 0 Geminivirus Rep catalytic domain V_ATPase_I PF01496.19 ETO19828.1 - 0.094 10.6 5.5 0.1 10.5 5.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_C10 PF01640.17 ETO19828.1 - 0.18 12.1 1.0 0.26 11.6 0.4 1.5 1 1 0 1 1 1 0 Peptidase C10 family FixG_C PF11614.8 ETO19828.1 - 0.31 11.2 3.1 0.59 10.4 2.5 1.9 1 1 0 1 1 1 0 IG-like fold at C-terminal of FixG, putative oxidoreductase Prefoldin_3 PF13758.6 ETO19828.1 - 0.38 10.8 6.5 5.2 7.2 1.2 2.2 1 1 1 2 2 2 0 Prefoldin subunit EF-G-binding_N PF07299.11 ETO19828.1 - 0.77 10.3 7.6 0.27 11.8 1.2 2.3 2 1 0 2 2 2 0 Elongation factor G-binding protein, N-terminal DUF2968 PF11180.8 ETO19828.1 - 1.2 8.8 13.3 0.28 10.8 9.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) RasGAP_C PF03836.15 ETO19828.1 - 1.7 8.8 15.5 1.1 9.4 2.8 2.2 1 1 1 2 2 2 0 RasGAP C-terminus DUF745 PF05335.13 ETO19828.1 - 2.1 8.0 6.4 2.8 7.6 6.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Bap31_Bap29_C PF18035.1 ETO19828.1 - 2.7 8.1 14.0 0.63 10.1 4.1 2.7 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain HAUS-augmin3 PF14932.6 ETO19828.1 - 2.8 7.5 16.1 4.3 6.8 16.1 1.3 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 ATG16 PF08614.11 ETO19828.1 - 3.1 8.0 16.6 17 5.6 16.6 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Sec20 PF03908.13 ETO19828.1 - 6.9 6.7 8.9 1.5 8.8 2.9 2.4 1 1 2 3 3 3 0 Sec20 Rootletin PF15035.6 ETO19828.1 - 8.3 6.4 16.1 3.7 7.5 1.3 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion BTB PF00651.31 ETO19829.1 - 3.3e-08 33.7 0.0 0.0017 18.6 0.0 2.7 3 0 0 3 3 3 2 BTB/POZ domain IBP39 PF11422.8 ETO19829.1 - 0.0055 16.5 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 Initiator binding protein 39 kDa CgtA PF06306.11 ETO19829.1 - 0.021 14.3 0.2 0.034 13.6 0.2 1.3 1 0 0 1 1 1 0 Beta-1,4-N-acetylgalactosaminyltransferase (CgtA) Zip PF02535.22 ETO19829.1 - 0.33 10.1 1.2 0.52 9.5 1.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Kinesin PF00225.23 ETO19830.1 - 4.9e-15 55.3 0.0 5.8e-15 55.0 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO19830.1 - 1.4e-08 34.8 0.0 1.5e-08 34.7 0.0 1.1 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 ETO19831.1 - 6.4e-52 176.5 1.1 4.3e-30 104.8 0.1 4.4 5 0 0 5 5 5 2 Kinesin motor domain DUF1413 PF07205.11 ETO19831.1 - 0.0048 16.9 1.5 0.014 15.4 1.5 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1413) DUF3021 PF11457.8 ETO19831.1 - 0.46 10.8 3.9 1.8 8.9 3.9 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DUF4806 PF16064.5 ETO19831.1 - 0.71 10.2 5.6 0.85 10.0 2.2 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) TED_complement PF07678.14 ETO19832.1 - 0.024 13.7 0.0 0.034 13.2 0.0 1.2 1 0 0 1 1 1 0 A-macroglobulin TED domain Ras PF00071.22 ETO19833.1 - 3e-32 111.5 0.1 3.5e-32 111.3 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO19833.1 - 3.4e-14 53.1 0.0 4.1e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO19833.1 - 5.5e-06 26.4 0.0 6.7e-06 26.2 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase Arf PF00025.21 ETO19833.1 - 2.6e-05 23.7 0.0 3.1e-05 23.5 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Glyco_tran_WbsX PF14307.6 ETO19833.1 - 0.069 12.6 0.0 0.13 11.7 0.0 1.4 1 1 0 1 1 1 0 Glycosyltransferase WbsX Kelch_1 PF01344.25 ETO19834.1 - 2.2e-23 81.6 4.5 1.2e-06 28.0 0.1 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO19834.1 - 3.3e-14 52.6 0.0 0.031 14.3 0.0 4.6 3 1 1 4 4 4 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO19834.1 - 5.2e-14 51.9 0.1 0.0035 17.6 0.0 4.6 2 1 2 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ETO19834.1 - 4.4e-09 36.4 2.0 0.065 13.5 0.0 4.8 5 0 0 5 5 5 3 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO19834.1 - 3.8e-08 33.0 1.1 0.0021 18.0 0.0 4.4 3 1 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO19834.1 - 0.19 11.8 0.1 2 8.5 0.1 2.7 2 0 0 2 2 2 0 Kelch motif Aldedh PF00171.22 ETO19836.1 - 1.3e-13 50.3 0.5 1.5e-13 50.1 0.5 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3046 PF11248.8 ETO19836.1 - 0.08 13.3 0.5 1.7 9.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3046) Synaphin PF05835.12 ETO19837.1 - 0.049 13.9 8.5 0.11 12.8 8.5 1.6 1 0 0 1 1 1 0 Synaphin protein BRCA-2_OB3 PF09104.10 ETO19837.1 - 0.08 12.6 0.1 0.19 11.4 0.1 1.6 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 DUF2098 PF09871.9 ETO19837.1 - 0.92 9.9 3.3 2.8 8.3 3.3 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) Kelch_6 PF13964.6 ETO19838.1 - 0.00037 20.7 0.5 4.6 7.7 0.0 4.0 4 1 1 5 5 5 2 Kelch motif Folate_carrier PF01770.18 ETO19840.1 - 4.3e-19 68.6 0.6 5.6e-19 68.2 0.6 1.2 1 0 0 1 1 1 1 Reduced folate carrier CAP_GLY PF01302.25 ETO19841.1 - 4e-13 49.2 0.0 7e-13 48.4 0.0 1.4 1 0 0 1 1 1 1 CAP-Gly domain Pkinase PF00069.25 ETO19843.1 - 0.0012 18.3 0.6 0.0019 17.6 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Tetrabrachion PF11401.8 ETO19843.1 - 0.057 13.4 0.0 0.11 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetrabrachion Pkinase PF00069.25 ETO19844.1 - 2.7e-29 102.4 4.2 9.4e-16 58.0 2.4 2.7 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19844.1 - 3e-10 39.8 5.7 0.00011 21.6 0.1 2.7 1 1 0 2 2 2 2 Protein tyrosine kinase Methyltransf_23 PF13489.6 ETO19845.1 - 1.6e-13 50.8 0.0 2.4e-13 50.2 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO19845.1 - 8.9e-11 41.8 0.0 2.6e-10 40.3 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO19845.1 - 9e-09 36.0 0.1 2.4e-08 34.6 0.1 1.7 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO19845.1 - 1.1e-07 32.4 0.0 3.5e-07 30.8 0.0 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO19845.1 - 1.4e-06 28.9 0.0 1.1e-05 26.1 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ETO19845.1 - 0.0042 17.2 0.0 0.0075 16.4 0.0 1.4 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_32 PF13679.6 ETO19845.1 - 0.015 15.3 0.0 0.029 14.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 ETO19845.1 - 0.044 13.1 0.0 0.18 11.1 0.0 1.9 1 1 0 1 1 1 0 ubiE/COQ5 methyltransferase family zf-RING_2 PF13639.6 ETO19847.1 - 1.7e-13 50.6 3.5 2.6e-13 50.0 3.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO19847.1 - 2.6e-09 36.8 4.8 4.1e-09 36.1 4.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO19847.1 - 5.9e-07 29.3 3.1 9.3e-07 28.6 3.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO19847.1 - 8.3e-07 28.6 2.9 8.3e-07 28.6 2.9 1.9 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO19847.1 - 1.4e-06 28.2 3.1 2.1e-06 27.6 1.8 1.9 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO19847.1 - 7.3e-06 25.7 2.3 1e-05 25.3 2.3 1.2 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO19847.1 - 1.6e-05 25.1 7.6 6.9e-05 23.0 7.6 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETO19847.1 - 0.00013 21.8 2.0 0.00022 21.1 2.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Zn_ribbon_17 PF17120.5 ETO19847.1 - 0.00028 20.5 3.8 0.00048 19.7 3.8 1.4 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 ETO19847.1 - 0.0017 18.6 1.6 0.0026 18.0 1.6 1.3 1 0 0 1 1 1 1 RING-like domain zf-ANAPC11 PF12861.7 ETO19847.1 - 0.0051 16.8 1.2 0.0099 15.9 1.2 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO19847.1 - 0.0088 15.9 3.9 0.024 14.5 4.0 1.6 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 FANCL_C PF11793.8 ETO19847.1 - 0.018 15.2 5.4 0.2 11.8 5.4 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain zf-C3HC4_4 PF15227.6 ETO19847.1 - 0.026 14.7 1.0 0.074 13.2 1.1 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 ETO19847.1 - 0.029 14.3 3.5 0.12 12.3 3.5 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 Zf_RING PF16744.5 ETO19847.1 - 0.033 14.3 1.8 0.065 13.4 1.8 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger RINGv PF12906.7 ETO19847.1 - 0.2 11.8 3.1 0.54 10.4 3.2 1.7 1 1 0 1 1 1 0 RING-variant domain zf-RING_10 PF16685.5 ETO19847.1 - 0.21 11.8 2.1 0.34 11.1 2.1 1.3 1 0 0 1 1 1 0 zinc RING finger of MSL2 PHD PF00628.29 ETO19847.1 - 0.22 11.4 2.7 0.45 10.4 2.7 1.5 1 1 0 1 1 1 0 PHD-finger DUF3039 PF11238.8 ETO19847.1 - 0.25 11.1 2.0 0.29 10.9 1.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3039) IBR PF01485.21 ETO19848.1 - 5.1e-06 26.6 6.4 1.1e-05 25.5 4.9 2.2 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain DUF5017 PF16409.5 ETO19848.1 - 0.022 14.2 0.2 0.035 13.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5017) PUB PF09409.10 ETO19849.1 - 0.0089 15.9 0.8 0.016 15.2 0.1 1.9 2 1 0 2 2 2 1 PUB domain HSF_DNA-bind PF00447.17 ETO19849.1 - 0.019 15.6 1.3 0.027 15.1 0.6 1.6 2 0 0 2 2 2 0 HSF-type DNA-binding zf-TRAF PF02176.18 ETO19850.1 - 5.8e-06 26.9 2.1 5.8e-06 26.9 2.1 2.3 2 1 0 2 2 2 1 TRAF-type zinc finger NAD_binding_11 PF14833.6 ETO19851.1 - 1.2e-07 31.9 0.0 1.7e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 ETO19852.1 - 3.5e-16 59.8 0.0 4.6e-16 59.4 0.0 1.1 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase 2-Hacid_dh_C PF02826.19 ETO19852.1 - 3e-07 30.0 0.0 4.5e-07 29.4 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ETO19852.1 - 0.012 15.2 0.5 2.3 7.7 0.3 2.3 1 1 1 2 2 2 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain GFO_IDH_MocA PF01408.22 ETO19852.1 - 0.013 16.3 0.0 0.02 15.7 0.0 1.4 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold IlvN PF07991.12 ETO19852.1 - 0.014 14.9 0.0 0.021 14.4 0.0 1.2 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain F420_oxidored PF03807.17 ETO19852.1 - 0.02 15.4 0.0 0.037 14.6 0.0 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent Peptidase_S10 PF00450.22 ETO19853.1 - 4.2e-26 92.3 0.2 4.9e-26 92.1 0.2 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF4446 PF14584.6 ETO19854.1 - 0.31 11.0 6.5 2.8 7.9 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4770 PF15994.5 ETO19854.1 - 0.41 10.9 11.0 0.84 9.8 11.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) DUF4834 PF16118.5 ETO19854.1 - 0.84 10.6 12.3 4.3 8.4 9.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AF-4 PF05110.13 ETO19854.1 - 1.1 7.3 21.8 1.3 7.0 21.8 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein RPA43_OB PF17875.1 ETO19854.1 - 1.6 9.3 8.6 0.66 10.6 5.3 1.8 1 1 1 2 2 2 0 RPA43 OB domain in RNA Pol I DUF1764 PF08576.10 ETO19854.1 - 2.5 9.1 7.1 5.4 8.0 3.8 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) TERB2 PF15101.6 ETO19854.1 - 3.7 7.6 14.5 0.67 10.0 11.0 1.5 2 0 0 2 2 2 0 Telomere-associated protein TERB2 DUF4407 PF14362.6 ETO19854.1 - 3.7 6.8 10.3 6 6.1 10.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EPL1 PF10513.9 ETO19854.1 - 3.8 7.9 14.6 1 9.8 9.9 2.0 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF4175 PF13779.6 ETO19854.1 - 5.2 4.8 25.6 6.7 4.5 25.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CSG2 PF16965.5 ETO19854.1 - 7.5 5.4 6.6 9.8 5.0 3.4 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator Pkinase PF00069.25 ETO19855.1 - 6.2e-07 29.1 0.0 1e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain FTA2 PF13095.6 ETO19855.1 - 0.0011 18.7 0.3 0.0018 17.9 0.3 1.4 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 DUF3114 PF11311.8 ETO19855.1 - 0.027 14.0 0.1 0.04 13.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3114) DUF1951 PF09188.10 ETO19855.1 - 0.028 14.4 0.2 0.051 13.5 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1951) DNA_pol_B_2 PF03175.13 ETO19856.1 - 1.5e-30 106.5 6.7 6e-26 91.3 1.6 3.1 2 1 0 2 2 2 2 DNA polymerase type B, organellar and viral zf-C2H2_jaz PF12171.8 ETO19862.1 - 0.00076 19.7 0.3 0.0016 18.6 0.3 1.6 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETO19862.1 - 0.0024 18.2 0.1 0.0048 17.2 0.1 1.5 1 0 0 1 1 1 1 Zinc-finger of C2H2 type Peptidase_C92 PF05708.12 ETO19863.1 - 0.12 12.5 0.2 0.13 12.3 0.2 1.2 1 0 0 1 1 1 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family RRM_1 PF00076.22 ETO19864.1 - 6.2e-17 61.2 0.0 1e-16 60.5 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO19864.1 - 0.0027 17.7 0.0 0.0054 16.7 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain Pkinase PF00069.25 ETO19865.1 - 0.018 14.4 0.0 0.029 13.8 0.0 1.3 1 0 0 1 1 1 0 Protein kinase domain CPP1-like PF11833.8 ETO19867.1 - 0.068 12.8 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Mucin PF01456.17 ETO19867.1 - 4.6 7.2 6.9 0.42 10.6 0.4 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF1516 PF07457.11 ETO19868.1 - 0.0026 17.9 2.6 0.004 17.4 2.6 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1516) TssN PF17555.2 ETO19868.1 - 0.069 12.5 10.0 0.082 12.3 10.0 1.0 1 0 0 1 1 1 0 Type VI secretion system, TssN FTO_CTD PF12934.7 ETO19868.1 - 0.095 12.5 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 FTO C-terminal domain BRI3BP PF14965.6 ETO19868.1 - 0.32 10.5 4.4 0.56 9.7 4.4 1.3 1 1 0 1 1 1 0 Negative regulator of p53/TP53 RGS PF00615.19 ETO19869.1 - 5.9e-09 36.2 0.0 1.5e-08 34.9 0.0 1.7 2 1 0 2 2 2 1 Regulator of G protein signaling domain DUF5432 PF17497.2 ETO19869.1 - 0.039 14.0 1.5 0.082 13.0 0.8 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5432) L31 PF09784.9 ETO19872.1 - 0.066 13.6 0.3 0.066 13.6 0.3 4.1 3 1 1 4 4 4 0 Mitochondrial ribosomal protein L31 AT_hook PF02178.19 ETO19872.1 - 0.07 13.0 1.7 0.23 11.4 1.7 2.0 1 0 0 1 1 1 0 AT hook motif FAM76 PF16046.5 ETO19873.1 - 3.5e-21 75.8 14.0 3.9e-21 75.7 14.0 1.1 1 0 0 1 1 1 1 FAM76 protein TPR_14 PF13428.6 ETO19875.1 - 0.00014 22.3 0.3 2.3 9.3 0.2 4.4 2 2 2 4 4 4 1 Tetratricopeptide repeat NRDE-2 PF08424.10 ETO19875.1 - 0.0069 15.5 2.4 0.09 11.9 0.0 2.8 2 1 0 2 2 2 1 NRDE-2, necessary for RNA interference HAT PF02184.16 ETO19875.1 - 0.011 15.7 2.6 0.37 10.8 0.2 3.4 3 0 0 3 3 3 0 HAT (Half-A-TPR) repeat Pkinase_Tyr PF07714.17 ETO19876.1 - 0.00044 19.6 0.0 0.00089 18.6 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO19876.1 - 0.001 18.5 0.0 0.0031 16.9 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain RolB_RolC PF02027.17 ETO19876.1 - 0.067 12.8 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 RolB/RolC glucosidase family Mucin PF01456.17 ETO19876.1 - 0.58 10.1 27.1 0.048 13.6 3.9 3.4 3 0 0 3 3 3 0 Mucin-like glycoprotein Zip PF02535.22 ETO19876.1 - 9 5.4 11.8 8 5.6 9.7 2.2 2 1 0 2 2 2 0 ZIP Zinc transporter Pkinase PF00069.25 ETO19877.1 - 8.9e-59 199.0 0.0 1.3e-58 198.5 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19877.1 - 1.2e-30 106.6 0.0 3.7e-30 105.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO19877.1 - 2e-05 24.1 0.0 4e-05 23.1 0.0 1.5 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO19877.1 - 9.1e-05 22.5 0.1 0.00036 20.5 0.1 1.9 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO19877.1 - 0.0001 21.7 0.0 0.0002 20.8 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO19877.1 - 0.0011 17.8 0.0 0.002 17.0 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ETO19877.1 - 0.022 14.3 0.0 0.042 13.4 0.0 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 ETO19877.1 - 0.048 13.2 0.4 0.088 12.4 0.0 1.6 2 0 0 2 2 2 0 Choline/ethanolamine kinase EF-hand_6 PF13405.6 ETO19878.1 - 1.6e-05 24.4 1.1 0.036 14.0 0.5 3.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO19878.1 - 6.2e-05 23.4 10.2 0.0013 19.1 4.1 3.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO19878.1 - 0.19 11.3 7.3 2.8 7.7 0.7 3.7 4 0 0 4 4 4 0 EF hand EF-hand_like PF09279.11 ETO19878.1 - 0.75 10.3 0.1 0.75 10.3 0.1 3.2 4 0 0 4 4 4 0 Phosphoinositide-specific phospholipase C, efhand-like Rsm1 PF08600.10 ETO19879.1 - 0.057 13.6 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 Rsm1-like zf-SAP30 PF13866.6 ETO19879.1 - 0.14 12.3 0.1 0.28 11.3 0.1 1.5 1 0 0 1 1 1 0 SAP30 zinc-finger CCDC53 PF10152.9 ETO19881.1 - 0.023 15.1 5.9 0.036 14.5 5.9 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Presenilin PF01080.17 ETO19881.1 - 2.4 6.8 8.1 2.6 6.7 8.1 1.2 1 0 0 1 1 1 0 Presenilin DUSP PF06337.12 ETO19882.1 - 1.7e-19 70.2 3.3 3.6e-19 69.2 3.3 1.5 1 0 0 1 1 1 1 DUSP domain Lectin_N PF03954.14 ETO19882.1 - 0.043 13.6 1.2 0.12 12.1 0.2 2.1 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Ovate PF04844.13 ETO19884.1 - 0.15 12.1 0.6 0.33 11.0 0.1 1.8 2 0 0 2 2 2 0 Transcriptional repressor, ovate His_Phos_2 PF00328.22 ETO19885.1 - 0.0016 17.9 0.0 0.0018 17.7 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) CLN3 PF02487.17 ETO19886.1 - 0.91 8.5 6.9 0.24 10.4 3.8 1.5 1 1 1 2 2 2 0 CLN3 protein UPF0767 PF15990.5 ETO19886.1 - 8.9 6.5 7.7 0.99 9.6 0.5 2.5 1 1 1 2 2 2 0 UPF0767 family Ferrochelatase PF00762.19 ETO19888.1 - 5.1e-82 275.5 0.2 6.6e-82 275.1 0.2 1.1 1 0 0 1 1 1 1 Ferrochelatase SatRNA_48 PF17485.2 ETO19889.1 - 0.036 13.2 0.3 0.057 12.5 0.3 1.2 1 0 0 1 1 1 0 Satellite RNA 48 kDa protein DUF4894 PF16235.5 ETO19889.1 - 0.075 13.4 1.1 0.45 10.9 0.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4894) V_ATPase_I PF01496.19 ETO19890.1 - 0.021 12.8 8.8 0.022 12.7 8.8 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Fmp27_WPPW PF10359.9 ETO19890.1 - 0.04 12.8 10.9 0.059 12.2 10.9 1.3 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF3584 PF12128.8 ETO19890.1 - 0.12 9.9 16.8 0.17 9.4 16.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF724 PF05266.14 ETO19890.1 - 0.22 11.4 14.2 0.47 10.3 14.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) CDC45 PF02724.14 ETO19890.1 - 0.35 9.1 12.7 0.38 9.0 12.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Peptidase_A3 PF02160.15 ETO19890.1 - 0.38 10.2 3.3 0.61 9.5 3.3 1.2 1 0 0 1 1 1 0 Cauliflower mosaic virus peptidase (A3) XhlA PF10779.9 ETO19890.1 - 0.38 11.0 10.4 0.042 14.1 5.8 1.8 1 1 1 2 2 2 0 Haemolysin XhlA FlxA PF14282.6 ETO19890.1 - 0.72 9.9 23.5 0.52 10.3 16.8 2.4 2 0 0 2 2 2 0 FlxA-like protein DUF948 PF06103.11 ETO19890.1 - 1.1 9.5 3.1 2.8 8.2 3.1 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Muted PF14942.6 ETO19890.1 - 1.7 9.0 19.9 0.16 12.3 15.3 1.8 2 0 0 2 2 2 0 Organelle biogenesis, Muted-like protein ERM PF00769.19 ETO19890.1 - 1.7 8.4 27.9 2.5 7.8 27.9 1.5 1 1 0 1 1 1 0 Ezrin/radixin/moesin family DUF4407 PF14362.6 ETO19890.1 - 1.8 7.8 9.2 2.6 7.3 9.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ALMT PF11744.8 ETO19890.1 - 2.9 6.6 12.4 1.4 7.6 9.5 1.7 2 0 0 2 2 2 0 Aluminium activated malate transporter BST2 PF16716.5 ETO19890.1 - 4 8.1 20.0 0.66 10.6 14.5 2.4 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 DUF745 PF05335.13 ETO19890.1 - 4.9 6.8 14.3 0.5 10.1 8.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF745) Exonuc_VII_L PF02601.15 ETO19890.1 - 5 6.6 16.6 0.43 10.1 11.7 1.7 2 0 0 2 2 2 0 Exonuclease VII, large subunit Presenilin PF01080.17 ETO19890.1 - 5.6 5.6 10.5 7.2 5.3 10.5 1.3 1 0 0 1 1 1 0 Presenilin B56 PF01603.20 ETO19891.1 - 1.3e-64 218.8 12.9 1e-49 169.7 5.8 2.0 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) Lectin_C PF00059.21 ETO19892.1 - 6.2e-36 123.4 18.3 3.2e-16 60.0 0.2 4.5 4 0 0 4 4 4 3 Lectin C-type domain Fibrinogen_C PF00147.18 ETO19892.1 - 1.4e-05 25.0 0.0 3.6e-05 23.7 0.0 1.7 1 0 0 1 1 1 1 Fibrinogen beta and gamma chains, C-terminal globular domain Xlink PF00193.17 ETO19892.1 - 0.034 14.5 2.7 13 6.3 0.0 3.7 4 0 0 4 4 4 0 Extracellular link domain CAP_GLY PF01302.25 ETO19894.1 - 2.8e-19 68.9 2.1 5.2e-19 68.0 2.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain CdiI PF07262.11 ETO19895.1 - 0.012 15.4 0.0 0.028 14.2 0.0 1.6 1 0 0 1 1 1 0 CDI immunity protein CcmH PF03918.14 ETO19895.1 - 0.061 12.6 0.0 0.12 11.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein SKG6 PF08693.10 ETO19895.1 - 0.093 12.1 2.4 0.2 11.1 2.4 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain LapA_dom PF06305.11 ETO19895.1 - 0.16 11.8 0.3 0.41 10.5 0.3 1.7 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain Laminin_G_3 PF13385.6 ETO19897.1 - 2e-14 54.0 0.5 3.5e-14 53.2 0.5 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily WSC PF01822.19 ETO19897.1 - 2.3e-10 40.5 12.9 3.9e-10 39.8 12.9 1.4 1 0 0 1 1 1 1 WSC domain Pentaxin PF00354.17 ETO19897.1 - 3.9e-07 30.0 0.1 7e-07 29.1 0.1 1.3 1 0 0 1 1 1 1 Pentaxin family Laminin_G_2 PF02210.24 ETO19897.1 - 0.00027 21.5 0.1 0.00046 20.8 0.1 1.3 1 0 0 1 1 1 1 Laminin G domain Lectin_C PF00059.21 ETO19898.1 - 0.025 15.3 1.6 0.05 14.3 0.7 2.0 2 0 0 2 2 2 0 Lectin C-type domain Leader_Trp PF08255.11 ETO19898.1 - 0.46 10.6 2.6 1.5 8.9 2.6 1.9 1 0 0 1 1 1 0 Trp-operon Leader Peptide Sulfotransfer_3 PF13469.6 ETO19899.1 - 9.6e-05 22.9 0.0 0.00017 22.1 0.0 1.4 1 0 0 1 1 1 1 Sulfotransferase family G-alpha PF00503.20 ETO19900.1 - 7.7e-16 58.2 2.3 8.4e-16 58.1 2.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit ATPase_2 PF01637.18 ETO19900.1 - 0.011 15.7 1.3 0.013 15.4 1.3 1.1 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea CSN7a_helixI PF18392.1 ETO19900.1 - 0.015 15.2 1.3 0.015 15.2 1.3 1.8 2 0 0 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain DUF3997 PF13162.6 ETO19900.1 - 0.026 14.8 0.7 0.046 14.0 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3997) AAA_29 PF13555.6 ETO19900.1 - 0.036 13.8 0.0 0.058 13.1 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 ETO19900.1 - 0.047 13.9 0.9 0.46 10.7 0.1 2.2 1 1 1 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO19900.1 - 0.049 13.7 0.0 0.083 13.0 0.0 1.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ETO19900.1 - 0.053 13.3 0.0 0.064 13.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 ETO19900.1 - 0.073 13.6 0.7 0.12 12.9 0.6 1.4 1 1 0 1 1 1 0 ABC transporter SurA_N_3 PF13624.6 ETO19900.1 - 0.12 12.1 2.0 0.21 11.3 0.4 2.2 1 1 0 2 2 2 0 SurA N-terminal domain CAP_GLY PF01302.25 ETO19901.1 - 7.2e-16 58.0 0.1 7.2e-16 58.0 0.1 2.1 2 0 0 2 2 2 1 CAP-Gly domain SAM_1 PF00536.30 ETO19902.1 - 0.00048 20.5 0.1 0.0011 19.3 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO19902.1 - 0.0043 17.1 0.0 0.009 16.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3245 PF11595.8 ETO19903.1 - 0.053 14.0 2.0 0.074 13.5 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) SAGA-Tad1 PF12767.7 ETO19904.1 - 1.5e-12 47.8 0.4 1.5e-12 47.8 0.4 2.5 2 1 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit GREB1 PF15782.5 ETO19904.1 - 0.17 9.0 6.4 0.2 8.7 6.4 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 ETO19904.1 - 0.25 10.0 11.3 0.42 9.3 11.3 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO19904.1 - 0.38 9.5 15.3 0.51 9.1 15.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 ETO19904.1 - 6.4 5.7 14.4 12 4.8 14.4 1.4 1 0 0 1 1 1 0 Solute carrier family 12 G-alpha PF00503.20 ETO19906.1 - 1.2e-15 57.6 0.2 1.2e-15 57.6 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Beta-lactamase2 PF13354.6 ETO19906.1 - 0.12 12.0 0.1 0.2 11.3 0.0 1.4 1 1 0 1 1 1 0 Beta-lactamase enzyme family SirB PF04247.12 ETO19908.1 - 0.13 12.4 11.4 0.17 12.0 8.6 2.0 2 0 0 2 2 2 0 Invasion gene expression up-regulator, SirB HlyD_2 PF12700.7 ETO19908.1 - 0.22 10.2 1.5 0.3 9.8 1.5 1.2 1 0 0 1 1 1 0 HlyD family secretion protein Myco_arth_vir_N PF09610.10 ETO19908.1 - 4.7 7.4 6.7 17 5.6 6.7 2.0 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) PDR_CDR PF06422.12 ETO19909.1 - 0.012 15.5 5.3 0.015 15.2 0.1 2.2 2 0 0 2 2 2 0 CDR ABC transporter DUF3810 PF12725.7 ETO19909.1 - 0.017 14.5 0.8 0.023 14.1 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3810) SARAF PF06682.12 ETO19909.1 - 0.024 14.3 2.3 0.036 13.7 2.3 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis DUF4484 PF14831.6 ETO19909.1 - 0.061 13.4 2.3 0.08 13.0 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) CDK5_activator PF03261.15 ETO19909.1 - 0.23 11.0 8.1 0.26 10.8 8.1 1.1 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Shisa PF13908.6 ETO19909.1 - 0.29 11.3 4.8 0.42 10.8 4.8 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CrgA PF06781.12 ETO19909.1 - 3.9 7.6 5.4 1.3 9.1 1.1 2.3 1 1 2 3 3 3 0 Cell division protein CrgA Actin PF00022.19 ETO19910.1 - 0.005 15.5 0.1 0.0061 15.2 0.1 1.1 1 0 0 1 1 1 1 Actin ESP PF16590.5 ETO19910.1 - 0.031 14.5 0.1 0.046 14.0 0.1 1.3 1 0 0 1 1 1 0 Exocrine gland-secreting peptide CTP_synth_N PF06418.14 ETO19911.1 - 1.9e-55 188.0 3.3 3.2e-39 134.9 1.0 2.1 2 0 0 2 2 2 2 CTP synthase N-terminus Menin PF05053.13 ETO19912.1 - 3.3 5.9 12.2 5.5 5.2 12.2 1.3 1 0 0 1 1 1 0 Menin XK-related PF09815.9 ETO19913.1 - 2.5e-10 39.9 3.9 3.1e-10 39.6 3.9 1.1 1 0 0 1 1 1 1 XK-related protein YhhN PF07947.14 ETO19913.1 - 0.013 15.1 3.3 0.018 14.6 3.3 1.2 1 0 0 1 1 1 0 YhhN family DUF1540 PF07561.11 ETO19913.1 - 0.032 14.5 0.4 0.063 13.6 0.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1540) Acetyltransf_1 PF00583.25 ETO19914.1 - 0.0011 19.2 0.0 0.0029 17.8 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO19914.1 - 0.0035 17.7 0.0 0.0089 16.4 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO19914.1 - 0.061 13.3 0.0 0.14 12.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain CLN3 PF02487.17 ETO19914.1 - 0.28 10.2 2.9 1.7 7.6 0.1 2.4 2 0 0 2 2 2 0 CLN3 protein DUF4834 PF16118.5 ETO19914.1 - 0.99 10.4 8.3 13 6.8 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF1754 PF08555.10 ETO19914.1 - 2.9 8.7 24.7 0.82 10.5 4.8 2.4 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Pox_A21 PF05323.12 ETO19914.1 - 3.4 8.3 9.0 6.2 7.4 2.9 2.9 3 0 0 3 3 3 0 Poxvirus A21 Protein FAM176 PF14851.6 ETO19914.1 - 6.7 6.4 8.0 1.5 8.4 2.9 2.7 3 1 0 3 3 3 0 FAM176 family DUF2207 PF09972.9 ETO19915.1 - 0.0028 16.5 0.1 0.0029 16.4 0.1 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Fig1 PF12351.8 ETO19915.1 - 0.2 11.6 2.6 0.22 11.4 1.0 1.8 2 0 0 2 2 2 0 Ca2+ regulator and membrane fusion protein Fig1 Orf78 PF06024.12 ETO19915.1 - 0.84 10.0 17.6 5.4e+02 1.0 17.6 2.3 1 1 0 1 1 1 0 Orf78 (ac78) NOA36 PF06524.12 ETO19916.1 - 0.023 14.1 18.4 0.027 13.8 18.4 1.1 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ETO19916.1 - 0.14 11.8 5.0 0.19 11.4 5.0 1.3 1 0 0 1 1 1 0 FAM176 family SDA1 PF05285.12 ETO19916.1 - 0.3 10.5 11.8 0.31 10.4 11.8 1.0 1 0 0 1 1 1 0 SDA1 Radial_spoke PF04712.12 ETO19916.1 - 0.44 9.4 4.4 0.41 9.5 4.4 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein Sigma70_ner PF04546.13 ETO19916.1 - 1.6 8.6 11.7 1.6 8.6 11.7 1.0 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.9 ETO19916.1 - 2.2 7.4 23.6 2.3 7.3 23.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RRN3 PF05327.11 ETO19916.1 - 2.7 6.4 9.8 2.5 6.5 9.8 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 ETO19916.1 - 2.8 7.1 6.3 3 7.0 6.3 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO19916.1 - 4.1 5.4 23.6 4.6 5.2 23.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO19916.1 - 6.6 4.8 15.4 7.2 4.7 15.4 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO19916.1 - 7.7 4.7 13.5 8.7 4.5 13.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 ETO19916.1 - 7.9 6.2 9.4 8.4 6.1 9.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RXT2_N PF08595.11 ETO19916.1 - 8.8 6.3 13.3 10 6.1 13.3 1.1 1 0 0 1 1 1 0 RXT2-like, N-terminal CobT PF06213.12 ETO19916.1 - 9.8 5.5 12.9 11 5.3 12.9 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Nucleoporin2 PF04096.14 ETO19917.1 - 1.4e-39 135.6 0.0 1.6e-39 135.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin autopeptidase Na_H_Exchanger PF00999.21 ETO19918.1 - 2.7e-07 29.7 2.2 3.5e-07 29.4 2.2 1.2 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family Peptidase_C78 PF07910.13 ETO19919.1 - 1.8e-10 40.7 0.0 2.8e-10 40.0 0.0 1.3 1 0 0 1 1 1 1 Peptidase family C78 Peptidase_C78 PF07910.13 ETO19920.1 - 2.6e-16 59.7 0.3 9e-16 58.0 0.0 1.7 1 1 1 2 2 2 1 Peptidase family C78 YL1 PF05764.13 ETO19920.1 - 0.046 13.8 10.2 0.068 13.3 10.2 1.2 1 0 0 1 1 1 0 YL1 nuclear protein CLN3 PF02487.17 ETO19920.1 - 0.54 9.2 1.6 0.34 9.9 0.1 1.4 2 0 0 2 2 2 0 CLN3 protein EOS1 PF12326.8 ETO19920.1 - 1.7 8.5 3.4 2.3 8.1 3.4 1.3 1 1 0 1 1 1 0 N-glycosylation protein Connexin PF00029.19 ETO19920.1 - 3.2 7.4 5.7 0.31 10.7 0.8 1.7 2 0 0 2 2 2 0 Connexin RNA_pol_Rbc25 PF08292.12 ETO19920.1 - 3.8 7.8 6.5 44 4.3 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 DUF3381 PF11861.8 ETO19920.1 - 4.6 7.0 17.5 0.08 12.7 10.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) SAM_1 PF00536.30 ETO19924.1 - 0.00017 21.9 0.1 0.00043 20.7 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO19924.1 - 0.00028 20.9 0.1 0.00057 19.9 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) ABC2_membrane_3 PF12698.7 ETO19925.1 - 4.6e-28 98.3 19.6 5.3e-28 98.1 19.6 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein NrsF PF06532.11 ETO19925.1 - 0.039 13.7 1.9 0.082 12.6 1.9 1.5 1 0 0 1 1 1 0 Negative regulator of sigma F ABC2_membrane_2 PF12679.7 ETO19925.1 - 0.29 10.4 16.1 0.65 9.2 16.1 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein ABC_tran PF00005.27 ETO19926.1 - 1.3e-19 71.1 0.0 2.1e-19 70.4 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ETO19926.1 - 0.17 12.3 0.8 0.26 11.8 0.1 1.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ETO19926.1 - 0.22 11.1 0.5 0.35 10.5 0.5 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Pex24p PF06398.11 ETO19926.1 - 1.3 7.9 0.0 1.3 7.9 0.0 2.1 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin MatE PF01554.18 ETO19927.1 - 4.5e-22 78.4 11.0 9e-22 77.4 4.4 2.5 2 0 0 2 2 2 2 MatE Polysacc_synt_C PF14667.6 ETO19927.1 - 0.016 15.3 0.8 0.016 15.3 0.8 3.4 2 1 0 3 3 3 0 Polysaccharide biosynthesis C-terminal domain LRR19-TM PF15176.6 ETO19927.1 - 0.47 10.5 2.0 4.5 7.3 0.0 3.0 3 0 0 3 3 3 0 Leucine-rich repeat family 19 TM domain Orf78 PF06024.12 ETO19927.1 - 0.51 10.7 2.5 34 4.8 1.3 2.8 2 0 0 2 2 2 0 Orf78 (ac78) SLC12 PF03522.15 ETO19928.1 - 3.6e-21 75.7 9.0 2.2e-10 40.2 0.0 3.7 2 2 1 3 3 3 2 Solute carrier family 12 PBP1_TM PF14812.6 ETO19928.1 - 0.0018 18.6 2.6 0.0042 17.4 2.6 1.5 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal WD40 PF00400.32 ETO19929.1 - 2.7e-54 179.9 25.4 1.3e-09 38.5 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19929.1 - 1.6e-19 70.0 5.5 0.0017 18.6 0.1 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19929.1 - 5.3e-15 55.2 0.1 0.0052 15.8 0.0 5.7 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO19929.1 - 1.3e-06 28.0 0.0 0.73 9.1 0.0 3.4 1 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO19929.1 - 8.9e-05 21.3 7.4 1.1 7.8 0.0 4.9 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Gmad1 PF10647.9 ETO19929.1 - 0.003 17.3 2.4 0.88 9.3 1.3 3.3 1 1 2 3 3 3 1 Lipoprotein LpqB beta-propeller domain Nucleoporin_N PF08801.11 ETO19929.1 - 0.004 16.0 6.1 5 5.8 0.2 4.5 1 1 3 4 4 4 2 Nup133 N terminal like Frtz PF11768.8 ETO19929.1 - 0.029 12.7 0.0 0.84 7.9 0.0 2.6 1 1 2 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO19929.1 - 0.044 13.7 3.8 8.1 6.5 0.1 4.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF4265 PF14085.6 ETO19929.1 - 0.13 12.3 0.0 2.7 8.0 0.0 3.1 2 1 3 5 5 5 0 Domain of unknown function (DUF4265) GPCR_chapero_1 PF11904.8 ETO19930.1 - 5.9e-11 42.4 7.1 5.9e-11 42.4 7.1 2.0 1 1 1 2 2 2 1 GPCR-chaperone Cyclase_polyket PF04673.12 ETO19930.1 - 0.062 13.6 0.1 0.16 12.2 0.1 1.6 1 0 0 1 1 1 0 Polyketide synthesis cyclase Cytomega_UL84 PF06284.11 ETO19930.1 - 0.15 10.5 3.3 0.096 11.1 1.7 1.6 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein NOA36 PF06524.12 ETO19930.1 - 3.7 6.8 9.0 1 8.6 2.2 2.2 2 0 0 2 2 2 0 NOA36 protein SURF2 PF05477.11 ETO19930.1 - 4.2 7.0 17.9 0.91 9.2 4.7 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) GPCR_chapero_1 PF11904.8 ETO19931.1 - 9.1e-25 87.7 5.0 1.9e-24 86.7 5.0 1.5 1 1 0 1 1 1 1 GPCR-chaperone COesterase PF00135.28 ETO19932.1 - 1e-09 37.8 0.0 1.8e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Carboxylesterase family Peptidase_S9 PF00326.21 ETO19932.1 - 3.1e-08 33.3 0.0 7e-06 25.7 0.0 2.4 2 0 0 2 2 2 2 Prolyl oligopeptidase family Abhydrolase_3 PF07859.13 ETO19932.1 - 4e-08 33.4 0.0 4.7e-07 29.9 0.0 2.1 2 0 0 2 2 2 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ETO19932.1 - 3.4e-06 27.0 0.0 0.0038 17.0 0.0 2.3 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Hydrolase_4 PF12146.8 ETO19932.1 - 1.3e-05 24.6 0.0 0.05 12.9 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 ETO19932.1 - 0.0023 17.5 0.0 0.0049 16.4 0.0 1.4 1 0 0 1 1 1 1 Dienelactone hydrolase family ABC_tran PF00005.27 ETO19934.1 - 5.3e-26 91.8 0.0 2.2e-15 57.4 0.0 2.6 2 0 0 2 2 2 2 ABC transporter AAA_21 PF13304.6 ETO19934.1 - 5.4e-06 26.4 5.0 0.46 10.2 0.0 4.1 3 1 1 4 4 4 3 AAA domain, putative AbiEii toxin, Type IV TA system RsgA_GTPase PF03193.16 ETO19934.1 - 0.022 14.7 0.0 0.067 13.1 0.0 1.7 2 0 0 2 2 2 0 RsgA GTPase AAA_7 PF12775.7 ETO19934.1 - 0.023 14.2 0.0 0.079 12.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region ATPase PF06745.13 ETO19934.1 - 0.027 13.8 0.1 0.05 13.0 0.1 1.4 1 0 0 1 1 1 0 KaiC SLC12 PF03522.15 ETO19934.1 - 0.07 12.1 6.1 0.11 11.5 6.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Nop14 PF04147.12 ETO19934.1 - 0.087 11.0 21.6 0.12 10.5 21.6 1.1 1 0 0 1 1 1 0 Nop14-like family TsaE PF02367.17 ETO19934.1 - 0.1 12.6 0.0 0.26 11.3 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_22 PF13401.6 ETO19934.1 - 0.11 12.8 0.0 0.24 11.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO19934.1 - 0.19 11.7 0.2 0.34 10.8 0.2 1.4 1 0 0 1 1 1 0 NACHT domain AAA_13 PF13166.6 ETO19934.1 - 0.24 10.0 0.0 0.24 10.0 0.0 2.4 2 0 0 2 2 2 0 AAA domain SAPS PF04499.15 ETO19934.1 - 2.3 6.9 8.2 3.6 6.2 8.2 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein DUF2201_N PF13203.6 ETO19934.1 - 2.4 7.7 6.4 5 6.6 6.4 1.6 1 0 0 1 1 1 0 Putative metallopeptidase domain Presenilin PF01080.17 ETO19934.1 - 2.7 6.7 11.9 3.9 6.1 11.9 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO19934.1 - 6.6 4.9 23.3 10 4.3 23.3 1.2 1 0 0 1 1 1 0 CDC45-like protein NTP_transf_2 PF01909.23 ETO19935.1 - 0.00043 20.5 0.0 0.0012 19.1 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain DUF4269 PF14091.6 ETO19935.1 - 0.00069 19.9 0.0 0.0014 18.9 0.0 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4269) Polbeta PF18765.1 ETO19935.1 - 0.0012 18.9 0.6 0.0073 16.4 0.1 2.4 2 1 1 3 3 3 1 Polymerase beta, Nucleotidyltransferase IL31 PF15209.6 ETO19935.1 - 0.052 13.3 0.4 0.099 12.4 0.4 1.4 1 0 0 1 1 1 0 Interleukin 31 SPO22 PF08631.10 ETO19935.1 - 0.054 13.0 0.2 0.063 12.8 0.2 1.1 1 0 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like Mon1 PF03164.14 ETO19936.1 - 2.9e-08 33.2 0.0 5.8e-08 32.2 0.0 1.5 1 1 0 1 1 1 1 Trafficking protein Mon1 LicD PF04991.13 ETO19936.1 - 4.5 7.3 18.2 1.8 8.7 14.8 1.8 1 1 1 2 2 2 0 LicD family PT PF04886.12 ETO19937.1 - 5.4e-46 153.8 194.7 7.8e-07 28.5 8.3 11.1 1 1 7 8 8 8 7 PT repeat Pkinase PF00069.25 ETO19938.1 - 4e-39 134.6 0.3 7.3e-39 133.7 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19938.1 - 1.8e-28 99.5 0.0 3.2e-28 98.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO19938.1 - 0.00013 21.4 0.0 0.00024 20.5 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO19938.1 - 0.00023 20.1 3.8 0.0023 16.8 0.0 2.2 2 0 0 2 2 2 1 Fungal protein kinase LRRFIP PF09738.9 ETO19938.1 - 0.12 11.9 11.7 0.03 13.8 8.0 1.7 1 1 1 2 2 2 0 LRRFIP family Uds1 PF15456.6 ETO19938.1 - 9.2 6.4 8.8 21 5.3 8.8 1.6 1 0 0 1 1 1 0 Up-regulated During Septation zf-CCCH PF00642.24 ETO19940.1 - 4.3e-07 29.7 17.5 1.4e-06 28.1 5.3 2.7 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO19940.1 - 9.2e-05 22.1 9.9 0.01 15.6 3.6 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ETO19940.1 - 0.00018 21.8 7.8 0.081 13.4 2.3 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 ETO19940.1 - 0.00063 19.7 14.4 0.011 15.8 6.6 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 ETO19940.1 - 0.00084 20.0 8.1 0.00084 20.0 8.1 4.9 5 1 1 6 6 6 1 Torus domain Methyltransf_11 PF08241.12 ETO19941.1 - 7.5e-23 81.0 0.0 1.6e-22 79.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO19941.1 - 2.8e-21 76.0 0.0 7.1e-21 74.7 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO19941.1 - 3.9e-19 68.9 0.0 7e-19 68.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO19941.1 - 1.7e-16 60.3 0.0 2.5e-16 59.7 0.0 1.4 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ETO19941.1 - 3.6e-10 39.9 0.0 6.9e-10 39.0 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO19941.1 - 1.6e-09 38.4 0.0 4e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETO19941.1 - 5.7e-06 26.0 0.0 1e-05 25.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PrmA PF06325.13 ETO19941.1 - 9.5e-05 21.9 0.0 0.00015 21.3 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) UPF0020 PF01170.18 ETO19941.1 - 0.0028 17.4 0.0 0.0049 16.6 0.0 1.5 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_32 PF13679.6 ETO19941.1 - 0.005 16.8 0.0 0.021 14.8 0.0 1.9 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 ETO19941.1 - 0.0061 16.5 0.0 0.019 14.9 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain AviRa PF11599.8 ETO19941.1 - 0.031 13.7 0.0 0.071 12.6 0.0 1.6 1 1 0 1 1 1 0 RRNA methyltransferase AviRa TilS PF09179.11 ETO19941.1 - 0.052 14.0 0.3 0.11 13.0 0.3 1.5 1 0 0 1 1 1 0 TilS substrate binding domain Methyltransf_15 PF09445.10 ETO19941.1 - 0.089 12.4 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase PCMT PF01135.19 ETO19941.1 - 0.14 11.9 0.0 0.19 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) HiaBD2 PF15403.6 ETO19941.1 - 0.18 12.2 0.1 0.33 11.4 0.1 1.4 1 0 0 1 1 1 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) DUF1387 PF07139.11 ETO19942.1 - 0.34 10.6 5.4 0.45 10.2 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Ferlin_C PF16165.5 ETO19942.1 - 4 7.4 5.5 6 6.8 5.4 1.5 1 1 0 1 1 1 0 Ferlin C-terminus Presenilin PF01080.17 ETO19943.1 - 0.77 8.5 11.0 1 8.0 11.0 1.2 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETO19943.1 - 1.3 10.0 9.1 9.9 7.2 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) BIRC6 PF12356.8 ETO19943.1 - 2.3 7.6 12.8 0.11 12.0 1.0 2.1 2 0 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 DUF2956 PF11169.8 ETO19943.1 - 3.2 8.0 9.9 8.2 6.7 2.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Nmad2 PF18753.1 ETO19943.1 - 4 6.8 11.6 0.17 11.3 0.3 2.1 2 0 0 2 2 2 0 Nucleotide modification associated domain 2 Ctr PF04145.15 ETO19943.1 - 4 8.0 7.7 2.5e+02 2.2 7.7 2.1 1 1 0 1 1 1 0 Ctr copper transporter family PBP1_TM PF14812.6 ETO19943.1 - 4.7 7.7 26.3 2 8.8 12.2 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Corazonin PF17308.2 ETO19943.1 - 5.8 7.3 22.4 5 7.5 16.8 2.3 2 0 0 2 2 2 0 Pro-corazonin CFIA_Pcf11 PF11526.8 ETO19943.1 - 7.7 7.1 24.3 3.5 8.2 14.1 2.4 2 1 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 U-box PF04564.15 ETO19944.1 - 7.9e-05 22.7 0.0 0.00017 21.7 0.0 1.6 1 0 0 1 1 1 1 U-box domain Myb_DNA-binding PF00249.31 ETO19944.1 - 0.028 14.6 0.0 0.057 13.6 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain ODV-E18 PF10717.9 ETO19944.1 - 0.12 12.2 0.0 0.25 11.2 0.0 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 Nop14 PF04147.12 ETO19945.1 - 0.17 10.1 43.8 0.2 9.8 43.8 1.0 1 0 0 1 1 1 0 Nop14-like family Raftlin PF15250.6 ETO19945.1 - 0.49 9.1 15.9 0.69 8.6 15.9 1.3 1 0 0 1 1 1 0 Raftlin DUF3299 PF11736.8 ETO19945.1 - 2.5 8.1 10.3 5.5 7.0 10.0 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3299) MCM_bind PF09739.9 ETO19945.1 - 3.7 5.9 15.4 4.8 5.5 15.4 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Hamartin PF04388.12 ETO19945.1 - 6.2 5.4 18.9 7.8 5.0 18.9 1.0 1 0 0 1 1 1 0 Hamartin protein Spem1 PF15670.5 ETO19945.1 - 9.4 5.7 9.8 13 5.3 9.8 1.2 1 0 0 1 1 1 0 Spermatid maturation protein 1 DUF3287 PF11690.8 ETO19946.1 - 0.025 14.3 0.1 0.067 12.9 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3287) LSM PF01423.22 ETO19947.1 - 8.7e-11 41.4 0.1 2.1e-10 40.1 0.1 1.7 1 0 0 1 1 1 1 LSM domain DUF898 PF05987.13 ETO19947.1 - 0.024 13.7 0.4 0.034 13.2 0.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) SSP160 PF06933.11 ETO19948.1 - 0.0034 15.7 6.9 0.0034 15.7 6.9 2.8 3 0 0 3 3 3 1 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO19948.1 - 0.014 15.4 7.1 0.014 15.4 7.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) RhoGEF PF00621.20 ETO19949.1 - 0.034 14.4 0.1 0.034 14.4 0.1 2.1 1 1 1 2 2 2 0 RhoGEF domain dsRBD2 PF17842.1 ETO19949.1 - 0.036 14.3 1.4 0.049 13.8 1.4 1.2 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 DUF2956 PF11169.8 ETO19949.1 - 0.1 12.8 7.3 0.16 12.2 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) PH_10 PF15411.6 ETO19949.1 - 0.51 10.6 0.1 0.51 10.6 0.1 2.2 1 1 0 2 2 2 0 Pleckstrin homology domain Suv3_N PF18114.1 ETO19949.1 - 0.6 10.2 3.8 0.5 10.5 2.6 1.5 1 1 0 1 1 1 0 Suv3 helical N-terminal domain COX6B PF02297.17 ETO19950.1 - 0.19 12.0 0.3 0.19 12.0 0.3 2.1 2 0 0 2 2 2 0 Cytochrome oxidase c subunit VIb FAM199X PF15814.5 ETO19950.1 - 1.9 7.5 5.7 1.1 8.2 4.1 1.4 1 1 0 1 1 1 0 Protein family FAM199X Mg_chelatase PF01078.21 ETO19951.1 - 0.0038 16.6 0.5 0.0075 15.7 0.5 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI FliT PF05400.13 ETO19951.1 - 0.0044 17.8 2.1 0.0044 17.8 2.1 2.0 2 0 0 2 2 2 1 Flagellar protein FliT AAA PF00004.29 ETO19951.1 - 0.0051 17.2 3.1 0.023 15.1 0.4 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) SPOUT_MTase PF02590.17 ETO19951.1 - 5.4 7.0 8.4 0.19 11.7 1.4 2.0 2 1 0 2 2 2 0 Predicted SPOUT methyltransferase CRIM PF16978.5 ETO19952.1 - 0.0056 16.8 0.3 0.0056 16.8 0.3 3.3 2 1 1 3 3 3 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain TEX13 PF15186.6 ETO19952.1 - 0.0092 15.7 7.8 0.021 14.5 7.8 1.6 1 0 0 1 1 1 1 Testis-expressed sequence 13 protein family Utp14 PF04615.13 ETO19952.1 - 0.1 11.2 31.0 0.012 14.2 12.9 2.0 2 0 0 2 2 2 0 Utp14 protein DUF853 PF05872.12 ETO19952.1 - 0.45 9.0 18.9 0.0085 14.7 7.9 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) TEX19 PF15553.6 ETO19952.1 - 2.7 7.9 8.9 3.8 7.5 0.6 2.3 2 0 0 2 2 2 0 Testis-expressed protein 19 Acetyltransf_1 PF00583.25 ETO19953.1 - 3.1e-09 37.1 0.0 4.6e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO19953.1 - 5.8e-06 26.3 0.0 1.1e-05 25.4 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO19953.1 - 7.8e-05 23.0 0.0 0.00015 22.1 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Methyltransf_12 PF08242.12 ETO19955.1 - 0.32 11.8 3.6 0.32 11.8 3.6 1.1 1 0 0 1 1 1 0 Methyltransferase domain APC_u15 PF16636.5 ETO19955.1 - 0.43 11.0 6.8 0.53 10.7 6.8 1.1 1 0 0 1 1 1 0 Unstructured region on APC between APC_crr regions 5 and 6 DUF4576 PF15144.6 ETO19955.1 - 0.99 9.3 3.8 1.1 9.1 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) Inhibitor_I71 PF12628.7 ETO19955.1 - 1.4 8.7 10.0 1.4 8.7 10.0 1.0 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor Orf78 PF06024.12 ETO19955.1 - 2 8.7 5.6 2.2 8.6 5.6 1.2 1 0 0 1 1 1 0 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO19955.1 - 3.1 8.4 10.9 3.4 8.3 10.9 1.1 1 0 0 1 1 1 0 Secretin N-terminal domain Aminotran_1_2 PF00155.21 ETO19956.1 - 5.5e-33 114.6 0.1 4.9e-19 68.7 0.0 2.2 2 0 0 2 2 2 2 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETO19956.1 - 0.03 13.6 0.1 0.37 10.0 0.0 2.0 2 0 0 2 2 2 0 Beta-eliminating lyase HECT PF00632.25 ETO19958.1 - 4.6e-14 52.6 0.1 1e-13 51.5 0.1 1.6 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Tetraspanin PF00335.20 ETO19959.1 - 0.061 13.0 2.4 0.11 12.2 0.1 1.9 1 1 1 2 2 2 0 Tetraspanin family PH_13 PF16652.5 ETO19960.1 - 0.00018 21.3 2.0 0.25 11.1 0.5 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH PF00169.29 ETO19960.1 - 0.00078 19.9 1.0 0.0015 19.0 1.0 1.5 1 1 0 1 1 1 1 PH domain TetR_C_23 PF17931.1 ETO19960.1 - 0.032 14.4 1.5 0.33 11.1 0.2 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Phage_integrase PF00589.22 ETO19960.1 - 0.14 12.0 0.4 1.3 8.8 0.0 2.0 2 0 0 2 2 2 0 Phage integrase family Seryl_tRNA_N PF02403.22 ETO19960.1 - 0.8 10.0 6.7 6.5 7.0 0.3 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain LRR_6 PF13516.6 ETO19961.1 - 1e-22 78.2 14.0 0.003 17.5 0.0 8.4 8 0 0 8 8 8 7 Leucine Rich repeat LRR_1 PF00560.33 ETO19961.1 - 6.9e-07 29.0 5.0 20 6.2 0.0 7.4 6 1 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 ETO19961.1 - 0.00017 21.3 10.5 2.3 8.1 0.0 5.3 4 2 0 4 4 4 2 Leucine rich repeat SRP-alpha_N PF04086.13 ETO19961.1 - 0.031 14.2 11.2 0.043 13.7 11.2 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal LRR_4 PF12799.7 ETO19961.1 - 0.36 11.3 16.7 1 9.9 0.8 5.9 4 1 3 7 7 7 0 Leucine Rich repeats (2 copies) Menin PF05053.13 ETO19961.1 - 0.59 8.4 9.1 0.79 8.0 9.1 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO19961.1 - 1.2 8.3 5.3 1.8 7.7 5.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO19961.1 - 2.4 6.4 11.2 3.4 5.8 11.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 ETO19961.1 - 2.9 6.3 10.5 4.1 5.8 10.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF4746 PF15928.5 ETO19961.1 - 8.1 5.8 8.5 13 5.1 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 ETO19963.1 - 0.014 13.7 9.0 0.015 13.6 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ETO19963.1 - 0.015 13.7 1.6 0.016 13.7 1.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Zip PF02535.22 ETO19963.1 - 0.025 13.8 3.2 0.029 13.6 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 ETO19963.1 - 0.036 13.1 4.9 0.046 12.7 4.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) YABBY PF04690.13 ETO19963.1 - 0.039 14.5 5.8 0.05 14.2 5.8 1.2 1 0 0 1 1 1 0 YABBY protein Presenilin PF01080.17 ETO19963.1 - 0.15 10.8 9.6 0.17 10.6 9.6 1.1 1 0 0 1 1 1 0 Presenilin Mucin PF01456.17 ETO19963.1 - 0.4 10.7 4.6 0.55 10.2 4.6 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein SLC12 PF03522.15 ETO19963.1 - 0.42 9.6 10.6 0.5 9.3 10.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CobT PF06213.12 ETO19963.1 - 0.51 9.7 11.1 0.69 9.2 11.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Menin PF05053.13 ETO19963.1 - 0.72 8.1 6.7 0.79 8.0 6.7 1.1 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.16 ETO19963.1 - 0.96 9.5 5.3 1.2 9.1 5.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 ETO19963.1 - 1.6 7.5 7.5 1.7 7.4 7.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Ctr PF04145.15 ETO19963.1 - 4.1 8.0 6.3 29 5.3 6.3 2.0 1 1 0 1 1 1 0 Ctr copper transporter family Sec1 PF00995.23 ETO19964.1 - 1.2e-27 97.4 7.4 1.5e-27 97.1 7.4 1.1 1 0 0 1 1 1 1 Sec1 family DUF4924 PF16271.5 ETO19964.1 - 0.0083 16.2 2.7 0.022 14.8 0.2 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF4924) TINF2_N PF14973.6 ETO19964.1 - 0.56 10.5 5.2 0.36 11.2 0.2 2.7 2 1 1 3 3 3 0 TERF1-interacting nuclear factor 2 N-terminus CTF_NFI PF00859.18 ETO19965.1 - 0.044 13.7 4.0 0.074 12.9 4.0 1.4 1 0 0 1 1 1 0 CTF/NF-I family transcription modulation region Alpha_GJ PF03229.13 ETO19965.1 - 4.8 7.8 8.9 0.93 10.1 5.3 1.7 2 0 0 2 2 2 0 Alphavirus glycoprotein J Podoplanin PF05808.11 ETO19965.1 - 7.7 6.6 12.1 1.9 8.6 8.4 1.8 1 1 0 1 1 1 0 Podoplanin WD40 PF00400.32 ETO19967.1 - 1.2e-52 174.7 14.0 6.1e-10 39.5 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19967.1 - 3.5e-19 68.9 0.6 0.015 15.6 0.0 6.4 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19967.1 - 1.8e-13 50.1 4.7 0.0022 17.0 0.5 5.6 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO19967.1 - 0.00038 20.5 1.9 0.76 9.9 0.0 4.4 3 2 1 4 4 4 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO19967.1 - 0.00056 19.8 4.3 7.8 6.6 0.0 5.1 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO19967.1 - 0.0019 17.6 1.7 8.3 5.7 0.1 4.3 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Resistin PF06954.11 ETO19967.1 - 0.022 15.3 0.3 26 5.4 0.0 4.1 4 1 1 5 5 5 0 Resistin Str_synth PF03088.16 ETO19967.1 - 0.046 13.9 0.0 29 4.9 0.0 3.7 3 0 0 3 3 3 0 Strictosidine synthase Proteasome_A_N PF10584.9 ETO19967.1 - 0.082 12.6 6.2 63 3.4 0.0 5.3 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF1442 PF07279.11 ETO19968.1 - 0.0077 15.6 0.1 0.012 14.9 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1442) Rgp1 PF08737.10 ETO19968.1 - 0.065 12.4 5.4 0.083 12.0 5.4 1.1 1 0 0 1 1 1 0 Rgp1 Sec34 PF04136.15 ETO19968.1 - 0.21 11.5 7.3 0.33 10.8 7.3 1.2 1 0 0 1 1 1 0 Sec34-like family DUF4200 PF13863.6 ETO19968.1 - 0.41 11.1 21.8 0.8 10.1 21.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Vfa1 PF08432.10 ETO19968.1 - 0.63 10.4 11.8 0.79 10.0 11.8 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 YabA PF06156.13 ETO19968.1 - 1.1 10.0 9.9 2 9.1 9.9 1.5 1 0 0 1 1 1 0 Initiation control protein YabA CENP-H PF05837.12 ETO19968.1 - 1.3 9.5 11.2 2.2 8.7 11.2 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Atg14 PF10186.9 ETO19968.1 - 2.3 7.2 14.7 2.9 6.9 13.9 1.5 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 V_ATPase_I PF01496.19 ETO19968.1 - 3.8 5.3 10.8 4.3 5.1 10.8 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Exonuc_VII_L PF02601.15 ETO19968.1 - 9.4 5.7 7.6 13 5.3 7.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit zf-TRAF PF02176.18 ETO19969.1 - 4.6e-06 27.2 1.6 4.6e-06 27.2 1.6 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger DUF272 PF03312.15 ETO19969.1 - 0.15 12.3 0.6 9.1 6.6 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF272) Pkinase PF00069.25 ETO19970.1 - 2.5e-44 151.6 0.0 1.9e-43 148.7 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO19970.1 - 1.8e-22 79.9 0.1 8.6e-14 51.4 0.0 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO19970.1 - 0.00019 20.9 0.1 0.00028 20.3 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO19970.1 - 0.00021 20.4 0.1 0.00034 19.7 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO19970.1 - 0.00034 19.5 0.0 0.00046 19.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO19970.1 - 0.0026 17.7 0.3 0.0041 17.1 0.3 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO19970.1 - 0.034 13.7 0.0 0.074 12.6 0.0 1.5 1 1 0 1 1 1 0 RIO1 family Pox_ser-thr_kin PF05445.11 ETO19970.1 - 0.058 12.4 0.0 0.069 12.1 0.0 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase HLH PF00010.26 ETO19971.1 - 0.047 13.6 0.0 0.073 13.0 0.0 1.6 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain CNOT1_TTP_bind PF16417.5 ETO19971.1 - 2 7.5 6.1 15 4.7 6.1 2.0 1 1 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 TTP binding domain FlaA PF04620.12 ETO19972.1 - 0.11 12.1 0.0 0.11 12.1 0.0 1.7 2 0 0 2 2 2 0 Flagellar filament outer layer protein Flaa THEG4 PF15834.5 ETO19972.1 - 4.7 7.2 10.7 0.97 9.4 7.0 1.8 2 0 0 2 2 2 0 Testis highly expressed protein 4 Sporozoite_P67 PF05642.11 ETO19973.1 - 0.00081 17.6 4.4 0.00081 17.6 4.4 1.5 2 0 0 2 2 2 1 Sporozoite P67 surface antigen Tim54 PF11711.8 ETO19973.1 - 0.06 12.1 3.3 0.11 11.2 3.3 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Sigma70_ner PF04546.13 ETO19973.1 - 0.21 11.4 7.5 0.073 12.9 3.2 2.0 2 0 0 2 2 2 0 Sigma-70, non-essential region DNA_pol_phi PF04931.13 ETO19973.1 - 0.3 9.1 14.5 0.45 8.6 14.5 1.2 1 0 0 1 1 1 0 DNA polymerase phi V_ATPase_I PF01496.19 ETO19973.1 - 0.41 8.5 4.3 0.76 7.6 4.3 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Pox_Ag35 PF03286.14 ETO19973.1 - 1 9.1 15.2 0.1 12.4 8.6 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein TRAP_alpha PF03896.16 ETO19973.1 - 1.5 7.9 6.8 2.8 7.1 6.8 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SDA1 PF05285.12 ETO19973.1 - 1.6 8.0 20.3 3 7.2 20.3 1.5 1 1 0 1 1 1 0 SDA1 CPSF100_C PF13299.6 ETO19973.1 - 2.5 8.2 8.7 0.25 11.5 3.6 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4637 PF15470.6 ETO19973.1 - 3.2 7.5 10.6 7.1 6.3 10.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) PI3K_1B_p101 PF10486.9 ETO19973.1 - 3.9 5.1 7.8 4.9 4.8 7.8 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RRN3 PF05327.11 ETO19973.1 - 4.3 5.8 10.1 7.1 5.0 10.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.13 ETO19973.1 - 4.6 7.3 20.5 27 4.7 20.5 2.0 1 1 0 1 1 1 0 YL1 nuclear protein NOA36 PF06524.12 ETO19973.1 - 6.7 5.9 19.3 14 4.9 19.3 1.5 1 0 0 1 1 1 0 NOA36 protein Mem_trans PF03547.18 ETO19974.1 - 0.0049 15.3 0.0 0.15 10.5 0.0 2.6 1 1 0 1 1 1 1 Membrane transport protein TauE PF01925.19 ETO19974.1 - 0.24 11.0 0.8 12 5.4 0.0 2.1 2 0 0 2 2 2 0 Sulfite exporter TauE/SafE Ycf66_N PF07444.11 ETO19974.1 - 3.4 7.9 6.7 34 4.6 4.6 2.9 3 1 1 4 4 4 0 Ycf66 protein N-terminus Sacchrp_dh_C PF16653.5 ETO19975.1 - 7.2e-38 131.2 0.0 1e-37 130.7 0.0 1.2 1 0 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ETO19975.1 - 8.2e-14 52.0 0.0 1.2e-13 51.4 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain AstA PF04958.12 ETO19975.1 - 0.098 11.2 0.0 0.15 10.6 0.0 1.2 1 0 0 1 1 1 0 Arginine N-succinyltransferase beta subunit GFO_IDH_MocA PF01408.22 ETO19975.1 - 0.098 13.5 0.0 0.16 12.8 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase family, NAD-binding Rossmann fold DUF2353 PF09789.9 ETO19976.1 - 3.2e-05 23.4 12.8 0.0007 19.1 6.5 2.1 1 1 1 2 2 2 2 Uncharacterized coiled-coil protein (DUF2353) GAS PF13851.6 ETO19976.1 - 0.00036 19.9 12.5 0.00075 18.9 9.1 2.0 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 ETO19976.1 - 0.00081 19.4 1.3 0.00081 19.4 1.3 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) EzrA PF06160.12 ETO19976.1 - 0.0046 15.2 9.9 0.0062 14.8 9.9 1.3 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA Fez1 PF06818.15 ETO19976.1 - 0.0049 17.3 10.3 0.023 15.2 10.3 1.9 1 1 0 1 1 1 1 Fez1 ATP-synt_D PF01813.17 ETO19976.1 - 0.013 15.4 6.1 0.023 14.6 6.1 1.4 1 1 0 1 1 1 0 ATP synthase subunit D KLRAQ PF10205.9 ETO19976.1 - 0.015 15.5 2.7 0.015 15.5 2.7 2.3 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein ZapB PF06005.12 ETO19976.1 - 0.015 15.7 7.4 0.015 15.7 7.4 3.6 1 1 2 3 3 3 0 Cell division protein ZapB Takusan PF04822.13 ETO19976.1 - 0.024 14.5 5.0 0.31 11.0 1.5 2.7 1 1 1 2 2 2 0 Takusan Atg14 PF10186.9 ETO19976.1 - 0.031 13.4 7.9 0.38 9.8 3.0 2.1 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 ETO19976.1 - 0.044 12.7 15.4 0.02 13.8 11.0 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein Filament PF00038.21 ETO19976.1 - 0.072 12.7 14.4 0.06 12.9 5.0 2.0 1 1 1 2 2 2 0 Intermediate filament protein APC_N_CC PF16689.5 ETO19976.1 - 0.088 12.9 0.5 0.088 12.9 0.5 2.8 2 1 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain MetOD2 PF18548.1 ETO19976.1 - 0.089 12.9 5.8 0.11 12.6 4.1 2.0 1 1 1 2 2 2 0 Metanogen output domain 2 Nup54 PF13874.6 ETO19976.1 - 0.093 12.8 6.7 0.17 12.0 6.1 1.7 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 UPF0242 PF06785.11 ETO19976.1 - 0.11 12.6 16.1 0.23 11.6 16.1 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 ETO19976.1 - 0.14 12.2 15.5 1.9 8.5 6.4 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HAUS-augmin3 PF14932.6 ETO19976.1 - 0.2 11.2 14.3 2.1 7.8 6.8 2.5 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 YabA PF06156.13 ETO19976.1 - 0.24 12.1 12.0 7.2 7.3 2.8 2.9 1 1 2 3 3 3 0 Initiation control protein YabA CC2-LZ PF16516.5 ETO19976.1 - 0.28 11.6 13.6 1.7 9.1 2.5 3.0 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator APG6_N PF17675.1 ETO19976.1 - 0.29 11.7 15.3 1.3 9.5 1.7 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region TMPIT PF07851.13 ETO19976.1 - 0.31 10.2 5.7 0.34 10.1 4.9 1.5 1 1 0 1 1 1 0 TMPIT-like protein AAA_13 PF13166.6 ETO19976.1 - 0.32 9.6 8.8 0.39 9.3 8.8 1.1 1 0 0 1 1 1 0 AAA domain FAM76 PF16046.5 ETO19976.1 - 0.35 10.2 6.9 0.44 9.9 6.9 1.1 1 0 0 1 1 1 0 FAM76 protein Seryl_tRNA_N PF02403.22 ETO19976.1 - 0.37 11.0 9.5 0.14 12.4 2.8 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 ETO19976.1 - 0.39 10.5 7.4 0.65 9.8 6.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) PRKG1_interact PF15898.5 ETO19976.1 - 0.44 11.5 12.5 0.1 13.5 4.7 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain CHD5 PF04420.14 ETO19976.1 - 0.47 10.3 4.7 0.59 10.0 2.9 1.9 1 1 1 2 2 2 0 CHD5-like protein CENP-H PF05837.12 ETO19976.1 - 0.49 10.8 11.5 1.5 9.3 5.8 2.2 1 1 0 2 2 2 0 Centromere protein H (CENP-H) HAUS6_N PF14661.6 ETO19976.1 - 0.67 9.5 7.2 1.1 8.8 7.2 1.6 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Mod_r PF07200.13 ETO19976.1 - 0.68 10.0 14.0 0.72 10.0 7.5 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein DUF2730 PF10805.8 ETO19976.1 - 0.72 10.0 10.2 0.5 10.5 1.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Occludin_ELL PF07303.13 ETO19976.1 - 0.75 10.6 7.8 0.36 11.6 3.0 2.2 1 1 1 2 2 2 0 Occludin homology domain TMF_TATA_bd PF12325.8 ETO19976.1 - 0.84 9.9 14.2 5.1 7.4 0.8 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding HSCB_C PF07743.13 ETO19976.1 - 0.94 10.0 7.3 0.37 11.3 0.3 2.7 1 1 1 2 2 2 0 HSCB C-terminal oligomerisation domain TolA_bind_tri PF16331.5 ETO19976.1 - 1.4 9.1 18.9 15 5.8 6.6 3.4 1 1 2 3 3 3 0 TolA binding protein trimerisation Tropomyosin_1 PF12718.7 ETO19976.1 - 1.6 8.9 13.6 2.5 8.3 13.6 1.3 1 0 0 1 1 1 0 Tropomyosin like Syntaxin_2 PF14523.6 ETO19976.1 - 1.6 9.1 10.4 20 5.6 4.8 2.9 1 1 2 3 3 3 0 Syntaxin-like protein ABC_tran_CTD PF16326.5 ETO19976.1 - 1.7 8.9 12.5 10 6.4 1.1 3.3 1 1 2 3 3 3 0 ABC transporter C-terminal domain HalX PF08663.10 ETO19976.1 - 1.9 8.9 9.4 0.64 10.4 0.4 3.4 2 2 1 3 3 3 0 HalX domain SOGA PF11365.8 ETO19976.1 - 2.1 9.5 9.3 1.1 10.4 3.0 2.4 1 1 2 3 3 3 0 Protein SOGA FlaC_arch PF05377.11 ETO19976.1 - 3.7 8.0 12.2 0.56 10.6 0.5 3.4 2 1 0 3 3 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 ETO19976.1 - 5.6 6.8 17.3 1.2 8.9 0.3 3.9 1 1 3 4 4 4 0 Septum formation initiator cwf21 PF08312.12 ETO19976.1 - 5.7 7.2 10.8 4.6 7.5 0.9 2.6 2 1 0 2 2 2 0 cwf21 domain Fzo_mitofusin PF04799.13 ETO19976.1 - 6 6.4 10.9 2.4 7.7 2.0 2.2 1 1 1 2 2 2 0 fzo-like conserved region V_ATPase_I PF01496.19 ETO19976.1 - 6.9 4.5 9.4 22 2.8 9.2 1.8 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family PH PF00169.29 ETO19977.1 - 0.0016 18.9 0.6 0.0043 17.5 0.6 1.8 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO19977.1 - 0.033 14.6 0.3 0.033 14.6 0.3 2.5 2 1 0 2 2 2 0 Pleckstrin homology domain Menin PF05053.13 ETO19977.1 - 0.042 12.2 7.0 0.053 11.9 7.0 1.2 1 0 0 1 1 1 0 Menin NST1 PF13945.6 ETO19977.1 - 0.44 10.6 21.4 0.049 13.7 16.8 1.8 2 0 0 2 2 2 0 Salt tolerance down-regulator Presenilin PF01080.17 ETO19977.1 - 0.69 8.6 8.2 1.1 7.9 8.2 1.3 1 0 0 1 1 1 0 Presenilin RMI1_N PF08585.12 ETO19977.1 - 0.85 9.3 7.2 0.4 10.4 4.7 1.8 2 0 0 2 2 2 0 RecQ mediated genome instability protein Ureide_permease PF07168.11 ETO19977.1 - 1.2 7.8 3.7 1.9 7.2 3.7 1.2 1 0 0 1 1 1 0 Ureide permease Macoilin PF09726.9 ETO19977.1 - 1.5 7.3 11.4 2.2 6.7 11.4 1.2 1 0 0 1 1 1 0 Macoilin family ALMT PF11744.8 ETO19977.1 - 2.8 6.7 6.1 4.5 6.0 6.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RNA_pol_Rpc4 PF05132.14 ETO19978.1 - 0.015 15.7 7.2 0.026 15.0 7.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 RNA_polI_A34 PF08208.11 ETO19978.1 - 0.7 10.0 19.8 0.81 9.7 19.8 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 ETO19978.1 - 0.88 9.3 13.1 0.9 9.3 13.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO19978.1 - 1.3 7.2 11.3 1.3 7.2 11.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3381 PF11861.8 ETO19980.1 - 6.9e-36 123.5 11.1 6.9e-36 123.5 11.1 1.4 1 1 1 2 2 2 1 Domain of unknown function (DUF3381) Phage_holin_6_1 PF09682.10 ETO19980.1 - 0.11 12.9 3.5 0.98 9.9 0.8 2.3 2 0 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) MDH PF02315.16 ETO19980.1 - 0.18 11.9 0.2 0.18 11.9 0.2 1.8 2 0 0 2 2 2 0 Methanol dehydrogenase beta subunit PVL_ORF50 PF07768.11 ETO19980.1 - 2.2 8.6 14.6 0.062 13.6 4.8 2.7 3 0 0 3 3 3 0 PVL ORF-50-like family AAA_25 PF13481.6 ETO19981.1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain IlvN PF07991.12 ETO19981.1 - 0.05 13.2 0.0 0.099 12.2 0.0 1.4 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain WD40 PF00400.32 ETO19983.1 - 2e-52 174.0 15.5 2.7e-10 40.6 0.1 6.5 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19983.1 - 1.7e-14 53.9 4.5 0.0002 21.6 0.1 5.3 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO19983.1 - 4.5e-11 42.3 0.0 0.22 10.4 0.0 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO19983.1 - 4.7e-07 29.9 0.6 0.038 13.9 0.1 3.4 2 2 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO19983.1 - 4e-06 26.6 3.1 4 7.5 0.0 6.2 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO19983.1 - 9.3e-06 24.6 5.7 0.4 9.3 0.0 4.2 2 1 0 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO19983.1 - 3.9e-05 23.1 0.0 0.23 10.7 0.0 2.4 2 0 0 2 2 2 2 WD40-like domain SGL PF08450.12 ETO19983.1 - 0.00014 21.6 0.2 0.011 15.3 0.0 2.7 1 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO19983.1 - 0.0011 17.6 0.0 1.6 7.2 0.0 3.1 1 1 1 3 3 3 2 Cytochrome D1 heme domain Str_synth PF03088.16 ETO19983.1 - 0.0022 18.0 0.1 0.16 12.1 0.0 3.7 3 2 3 6 6 6 1 Strictosidine synthase Gmad1 PF10647.9 ETO19983.1 - 0.021 14.6 0.7 0.31 10.7 0.2 2.6 2 2 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain HARP PF07443.13 ETO19983.1 - 0.13 11.9 1.9 11 5.8 0.2 3.9 4 0 0 4 4 4 0 HepA-related protein (HARP) WD40 PF00400.32 ETO19984.1 - 1e-44 149.6 12.4 2.1e-08 34.7 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO19984.1 - 2.9e-12 46.7 5.8 0.21 11.9 0.0 5.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO19984.1 - 6e-10 38.9 2.2 0.00018 20.9 0.0 3.1 3 1 1 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO19984.1 - 9.7e-07 28.1 1.5 0.77 8.7 0.0 4.5 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO19984.1 - 1.3e-06 27.2 0.6 0.017 13.7 0.5 2.8 2 1 0 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO19984.1 - 3.9e-05 22.5 6.6 0.95 8.0 0.1 5.1 1 1 1 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO19984.1 - 4.5e-05 22.4 8.8 0.86 8.3 0.5 5.1 1 1 3 5 5 5 2 Nup133 N terminal like Utp8 PF10395.9 ETO19984.1 - 0.0074 14.8 3.6 0.079 11.5 0.2 2.6 1 1 1 2 2 2 1 Utp8 family DUF4999 PF16390.5 ETO19984.1 - 0.56 10.5 2.4 45 4.4 0.0 4.0 6 0 0 6 6 6 0 Domain of unknown function RabGAP-TBC PF00566.18 ETO19985.1 - 0.00066 19.4 1.0 0.00066 19.4 1.0 2.7 1 1 2 3 3 3 2 Rab-GTPase-TBC domain Umbravirus_LDM PF04817.12 ETO19985.1 - 0.0038 16.6 3.1 0.0054 16.1 3.1 1.2 1 0 0 1 1 1 1 Umbravirus long distance movement (LDM) family RabGAP-TBC PF00566.18 ETO19986.1 - 1e-23 84.2 2.0 1.5e-23 83.6 2.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF3040 PF11239.8 ETO19986.1 - 0.15 12.3 0.1 0.4 11.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) Ank_3 PF13606.6 ETO19987.1 - 0.019 15.5 0.5 0.48 11.1 0.2 3.0 4 0 0 4 4 4 0 Ankyrin repeat V_ATPase_I PF01496.19 ETO19988.1 - 4.9e-217 722.7 9.7 6.1e-217 722.4 9.7 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family RWD PF05773.22 ETO19989.1 - 5.7e-16 58.9 0.7 8.5e-16 58.3 0.7 1.3 1 0 0 1 1 1 1 RWD domain FPP PF05911.11 ETO19989.1 - 0.011 14.0 4.1 0.012 13.9 4.1 1.2 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil TRAP_beta PF05753.14 ETO19990.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) TRAP_beta PF05753.14 ETO19991.1 - 0.13 11.7 0.0 0.15 11.5 0.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) PAPS_reduct PF01507.19 ETO19992.1 - 0.011 15.8 0.2 2.3 8.2 0.0 2.3 2 0 0 2 2 2 0 Phosphoadenosine phosphosulfate reductase family zf-UBR PF02207.20 ETO19993.1 - 0.0053 16.9 3.7 0.0053 16.9 3.7 2.3 2 0 0 2 2 2 1 Putative zinc finger in N-recognin (UBR box) NACHT PF05729.12 ETO19994.1 - 2.8e-18 66.4 0.0 7.1e-18 65.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain RNA_pol_3_Rpc31 PF11705.8 ETO19994.1 - 0.0041 17.4 15.4 0.01 16.1 15.4 1.7 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Myc_N PF01056.18 ETO19994.1 - 0.017 15.1 5.6 0.024 14.5 5.6 1.3 1 0 0 1 1 1 0 Myc amino-terminal region DNA_pol_phi PF04931.13 ETO19994.1 - 0.027 12.6 15.6 0.057 11.5 15.6 1.6 1 0 0 1 1 1 0 DNA polymerase phi RNA_helicase PF00910.22 ETO19994.1 - 0.027 14.9 2.2 5.6 7.4 0.0 3.8 3 1 1 4 4 4 0 RNA helicase AAA_22 PF13401.6 ETO19994.1 - 0.038 14.3 0.1 0.34 11.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain NOA36 PF06524.12 ETO19994.1 - 0.041 13.2 13.0 0.079 12.3 13.0 1.4 1 0 0 1 1 1 0 NOA36 protein AAA_16 PF13191.6 ETO19994.1 - 0.11 12.9 0.1 0.46 10.9 0.0 2.1 1 1 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ETO19994.1 - 0.14 11.5 0.0 0.27 10.5 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ORC_WH_C PF18137.1 ETO19994.1 - 0.17 11.9 8.5 0.45 10.6 8.5 1.7 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Astro_capsid_p PF12226.8 ETO19994.1 - 0.18 10.9 9.5 0.39 9.8 9.5 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein BSP_II PF05432.11 ETO19994.1 - 0.36 10.5 23.8 0.66 9.6 23.8 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Connexin PF00029.19 ETO19994.1 - 0.64 9.7 4.5 1.1 8.9 4.5 1.4 1 0 0 1 1 1 0 Connexin TRAP_alpha PF03896.16 ETO19994.1 - 1.2 8.3 10.5 2 7.6 10.5 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4746 PF15928.5 ETO19994.1 - 1.7 8.0 19.8 4.5 6.6 18.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Presenilin PF01080.17 ETO19994.1 - 2.2 7.0 6.1 2.9 6.5 6.1 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO19994.1 - 5.1 6.2 7.3 7.3 5.7 7.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter MscS_TM PF12794.7 ETO19994.1 - 5.3 5.8 5.7 7.8 5.2 5.7 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF2407_C PF13373.6 ETO19994.1 - 5.6 7.1 8.0 0.6 10.3 2.3 2.3 2 1 0 2 2 2 0 DUF2407 C-terminal domain FAM176 PF14851.6 ETO19994.1 - 6.7 6.4 14.3 1.5 8.5 10.7 1.7 2 0 0 2 2 1 0 FAM176 family CobT PF06213.12 ETO19994.1 - 8.1 5.7 15.6 13 5.1 15.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT SPRY PF00622.28 ETO19995.1 - 0.00057 20.0 0.5 0.00098 19.2 0.4 1.7 1 1 1 2 2 2 1 SPRY domain DUF3528 PF12045.8 ETO19995.1 - 0.054 14.1 0.3 0.092 13.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3528) Regulator_TrmB PF11495.8 ETO19995.1 - 0.17 11.0 0.0 0.23 10.6 0.0 1.1 1 0 0 1 1 1 0 Archaeal transcriptional regulator TrmB G-alpha PF00503.20 ETO19996.1 - 5.1e-06 25.9 0.1 8.7e-06 25.1 0.1 1.3 1 0 0 1 1 1 1 G-protein alpha subunit HMMR_C PF15908.5 ETO19997.1 - 0.016 15.5 6.1 0.016 15.5 6.1 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor C-terminal Tropomyosin_1 PF12718.7 ETO19997.1 - 0.025 14.8 17.4 0.12 12.5 2.5 3.0 2 1 1 3 3 3 0 Tropomyosin like DUF2205 PF10224.9 ETO19997.1 - 0.036 14.0 6.0 0.1 12.6 0.2 2.6 2 0 0 2 2 2 0 Short coiled-coil protein MbeD_MobD PF04899.12 ETO19997.1 - 0.11 12.7 4.7 3.5 7.8 0.9 2.6 2 1 0 2 2 2 0 MbeD/MobD like DivIC PF04977.15 ETO19997.1 - 0.25 11.1 10.8 3.7 7.4 0.1 3.1 3 0 0 3 3 3 0 Septum formation initiator SlyX PF04102.12 ETO19997.1 - 1.3 9.7 5.1 15 6.3 0.1 2.6 2 0 0 2 2 2 0 SlyX bZIP_2 PF07716.15 ETO19997.1 - 2 8.5 11.7 8 6.6 3.9 2.7 2 0 0 2 2 2 0 Basic region leucine zipper ALMT PF11744.8 ETO19997.1 - 5.4 5.7 7.3 1.1 8.0 4.0 1.5 2 0 0 2 2 2 0 Aluminium activated malate transporter PARP PF00644.20 ETO19998.1 - 3.5e-05 23.5 0.1 3.5e-05 23.5 0.1 2.1 2 1 1 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain IBR PF01485.21 ETO19998.1 - 0.0033 17.6 6.2 0.0033 17.6 6.2 3.8 3 1 0 3 3 3 1 IBR domain, a half RING-finger domain UFC1 PF08694.11 ETO19998.1 - 0.058 13.0 0.5 0.13 11.9 0.5 1.6 1 0 0 1 1 1 0 Ubiquitin-fold modifier-conjugating enzyme 1 PDR_assoc PF08370.11 ETO19998.1 - 0.14 12.0 0.7 0.41 10.4 0.0 2.0 2 0 0 2 2 2 0 Plant PDR ABC transporter associated EFP_N PF08207.12 ETO19999.1 - 0.024 14.7 0.3 0.19 11.8 0.1 2.5 2 1 0 2 2 2 0 Elongation factor P (EF-P) KOW-like domain DUF3655 PF12379.8 ETO19999.1 - 9.3 6.6 10.1 7.3 7.0 0.7 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3655) SAM_1 PF00536.30 ETO20001.1 - 0.0014 19.0 0.1 0.0023 18.3 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO20001.1 - 0.03 14.4 0.0 0.045 13.9 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) PepSY_2 PF13670.6 ETO20002.1 - 0.3 11.1 5.7 1.2 9.1 3.0 2.3 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Auts2 PF15336.6 ETO20002.1 - 0.94 9.6 5.8 0.93 9.6 5.4 1.3 1 1 0 1 1 1 0 Autism susceptibility gene 2 protein Fijivirus_P9-2 PF06837.11 ETO20003.1 - 2.4 7.5 7.7 2.5 7.5 7.7 1.0 1 0 0 1 1 1 0 Fijivirus P9-2 protein B56 PF01603.20 ETO20004.1 - 1e-47 163.1 5.0 1.5e-47 162.5 5.0 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Castor1_N PF18700.1 ETO20004.1 - 0.091 12.6 0.4 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain Beach PF02138.18 ETO20005.1 - 5.5e-114 380.2 0.2 1.1e-113 379.3 0.2 1.5 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO20005.1 - 3.8e-07 30.1 0.3 3.7e-06 26.9 0.3 2.9 1 1 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ETO20005.1 - 5.7e-06 27.0 0.8 0.00075 20.3 0.0 3.7 3 0 0 3 3 3 1 WD domain, G-beta repeat GRAM PF02893.20 ETO20005.1 - 0.089 12.7 0.8 0.58 10.1 0.0 2.6 2 1 0 2 2 2 0 GRAM domain Metallophos PF00149.28 ETO20006.1 - 3e-11 44.2 0.2 5.4e-11 43.4 0.2 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase FBPase_2 PF06874.11 ETO20006.1 - 3.5e-07 28.9 0.2 0.0013 17.1 0.0 3.1 2 1 1 3 3 3 3 Firmicute fructose-1,6-bisphosphatase Plus-3 PF03126.18 ETO20007.1 - 4.2e-14 53.0 1.6 4.2e-14 53.0 1.6 3.3 2 1 0 2 2 2 1 Plus-3 domain Topo_C_assoc PF14370.6 ETO20007.1 - 0.02 14.8 0.5 0.056 13.4 0.5 1.8 1 0 0 1 1 1 0 C-terminal topoisomerase domain DUF1700 PF08006.11 ETO20007.1 - 0.81 9.2 5.8 2.7 7.5 5.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) DUF4834 PF16118.5 ETO20008.1 - 0.0093 16.9 1.3 0.018 16.0 0.1 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) DUF4456 PF14644.6 ETO20008.1 - 0.016 14.9 0.1 0.032 13.9 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4456) DUF4704 PF15787.5 ETO20009.1 - 3.3e-06 26.6 0.1 6.9e-06 25.5 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4704) DUF2098 PF09871.9 ETO20009.1 - 0.081 13.3 0.1 0.3 11.4 0.1 1.9 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2098) DUF4752 PF15944.5 ETO20009.1 - 0.47 10.5 3.0 1.6 8.8 1.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4752) zf-HC5HC2H_2 PF13832.6 ETO20010.1 - 9.2e-21 74.1 5.8 9.2e-21 74.1 5.8 3.0 3 1 0 3 3 3 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO20010.1 - 6.7e-16 58.3 2.1 6.7e-16 58.3 2.1 3.4 2 1 1 3 3 3 1 PHD-like zinc-binding domain PHD PF00628.29 ETO20010.1 - 6.8e-10 38.7 31.7 1.8e-05 24.5 5.3 4.2 4 0 0 4 4 4 3 PHD-finger PHD_2 PF13831.6 ETO20010.1 - 1.1e-07 31.3 4.7 1.1e-07 31.3 4.7 5.6 6 0 0 6 6 6 2 PHD-finger C1_1 PF00130.22 ETO20010.1 - 9.2e-06 25.5 20.6 0.017 15.0 1.9 3.6 3 0 0 3 3 3 3 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ETO20010.1 - 0.03 14.6 31.0 0.37 11.1 3.0 3.9 3 1 0 3 3 3 0 C1 domain Prok-RING_1 PF14446.6 ETO20010.1 - 4.5 7.3 32.3 4 7.4 9.9 3.4 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 E2R135 PF11570.8 ETO20011.1 - 0.0013 19.1 7.4 0.0043 17.3 7.2 2.1 1 1 0 1 1 1 1 Coiled-coil receptor-binding R-domain of colicin E2 Tropomyosin_1 PF12718.7 ETO20011.1 - 0.013 15.6 23.7 0.013 15.6 23.7 4.6 3 1 1 4 4 4 0 Tropomyosin like ADIP PF11559.8 ETO20011.1 - 0.014 15.5 12.4 0.014 15.5 12.4 5.2 2 1 2 5 5 5 0 Afadin- and alpha -actinin-Binding Fez1 PF06818.15 ETO20011.1 - 8.1 6.8 54.7 9.2 6.7 27.0 3.7 1 1 2 3 3 3 0 Fez1 Macoilin PF09726.9 ETO20012.1 - 2.4 6.6 10.2 2.7 6.5 10.2 1.0 1 0 0 1 1 1 0 Macoilin family zf-C2H2_4 PF13894.6 ETO20013.1 - 1.8e-05 25.2 10.9 0.00079 20.1 1.5 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO20013.1 - 0.00025 21.3 12.5 0.072 13.6 3.2 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO20013.1 - 0.00033 21.0 0.8 0.00033 21.0 0.8 2.4 2 0 0 2 2 2 1 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ETO20013.1 - 0.0032 17.7 5.5 0.1 12.9 0.5 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 ETO20013.1 - 0.0078 16.2 4.9 0.46 10.5 0.6 2.9 2 0 0 2 2 2 2 BED zinc finger zf-C2H2_11 PF16622.5 ETO20013.1 - 0.019 14.7 2.5 0.019 14.7 2.5 2.0 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-Di19 PF05605.12 ETO20013.1 - 0.027 14.8 5.8 0.081 13.2 5.8 1.8 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-met PF12874.7 ETO20013.1 - 0.034 14.6 9.0 0.38 11.2 2.5 2.7 2 0 0 2 2 2 0 Zinc-finger of C2H2 type WDCP PF15390.6 ETO20013.1 - 0.049 12.0 8.6 0.059 11.8 8.6 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family PI3K_1B_p101 PF10486.9 ETO20013.1 - 0.058 11.2 8.0 0.066 11.0 8.0 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Presenilin PF01080.17 ETO20013.1 - 0.18 10.6 19.2 0.27 10.0 19.2 1.3 1 0 0 1 1 1 0 Presenilin zf-H2C2_5 PF13909.6 ETO20013.1 - 0.49 10.2 7.0 0.13 12.0 2.6 2.4 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Dsh_C PF12316.8 ETO20013.1 - 0.81 10.1 7.9 0.94 9.9 7.1 1.6 1 1 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal zf-AN1 PF01428.16 ETO20013.1 - 1.1 9.5 7.3 3.3 7.9 1.1 2.4 1 1 1 2 2 2 0 AN1-like Zinc finger GREB1 PF15782.5 ETO20013.1 - 3.1 4.8 15.6 3.6 4.6 15.6 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Dapper PF15268.6 ETO20013.1 - 3.8 6.3 20.2 4.8 5.9 20.2 1.1 1 0 0 1 1 1 0 Dapper CAC1F_C PF16885.5 ETO20013.1 - 4.1 7.0 12.5 5.8 6.5 12.5 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LAP1C PF05609.12 ETO20013.1 - 4.7 6.2 18.6 6.1 5.8 18.6 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BAF1_ABF1 PF04684.13 ETO20013.1 - 4.8 6.1 43.2 7.1 5.6 43.2 1.2 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Macoilin PF09726.9 ETO20013.1 - 8 4.9 27.8 9.7 4.6 27.8 1.1 1 0 0 1 1 1 0 Macoilin family UPF0239 PF06783.11 ETO20013.1 - 8.1 6.7 12.6 0.31 11.2 1.9 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) WD40 PF00400.32 ETO20014.1 - 6.5e-32 109.1 25.9 2.7e-05 24.8 0.0 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20014.1 - 7.9e-08 32.5 1.4 0.25 11.7 0.0 5.5 5 1 1 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20014.1 - 1.5e-06 27.2 6.2 0.33 9.5 0.2 5.2 3 3 1 4 4 4 4 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO20014.1 - 0.21 11.4 0.9 2.1 8.2 0.0 3.0 4 0 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain Transketolase_N PF00456.21 ETO20015.1 - 2.3e-133 444.3 0.0 2.7e-133 444.1 0.0 1.0 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain DXP_synthase_N PF13292.6 ETO20015.1 - 2.6e-05 23.6 0.3 0.0022 17.2 0.1 2.2 1 1 1 2 2 2 2 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ETO20015.1 - 6.9e-05 22.7 0.1 0.00039 20.2 0.1 2.0 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain Terpene_synth PF01397.21 ETO20015.1 - 0.015 15.0 0.1 0.029 14.1 0.1 1.3 1 0 0 1 1 1 0 Terpene synthase, N-terminal domain RCC1 PF00415.18 ETO20017.1 - 4.7e-14 52.7 2.1 1.1e-11 45.1 0.1 3.0 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO20017.1 - 0.0049 16.6 8.6 0.054 13.3 1.6 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Hid1 PF12722.7 ETO20017.1 - 0.17 9.9 5.8 0.23 9.5 5.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4834 PF16118.5 ETO20017.1 - 0.51 11.3 7.3 5.1 8.1 7.3 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) ALMT PF11744.8 ETO20017.1 - 8.7 5.0 7.6 16 4.2 7.6 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Cas1_AcylT PF07779.12 ETO20018.1 - 2.4e-63 214.7 39.8 1.2e-62 212.4 39.8 1.9 1 1 0 1 1 1 1 10 TM Acyl Transferase domain found in Cas1p HSP70 PF00012.20 ETO20019.1 - 0.0037 15.5 0.2 0.012 13.8 0.0 1.7 1 1 0 2 2 2 1 Hsp70 protein Importin_rep_4 PF18808.1 ETO20019.1 - 1.1 9.6 4.3 27 5.1 2.3 2.9 2 1 0 2 2 2 0 Importin repeat WD40 PF00400.32 ETO20020.1 - 1.5e-06 28.8 11.7 0.0002 22.1 0.5 3.9 3 2 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20020.1 - 0.0018 18.6 0.0 0.29 11.5 0.0 2.5 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO20020.1 - 0.0025 17.7 0.1 0.059 13.2 0.1 2.1 2 0 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO20020.1 - 0.19 10.3 3.1 0.35 9.4 1.0 2.1 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Pkinase PF00069.25 ETO20021.1 - 8.6e-62 208.9 0.2 1.3e-61 208.3 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20021.1 - 1.5e-29 103.1 0.5 5.4e-28 98.0 0.2 2.0 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO20021.1 - 0.034 13.1 0.7 0.052 12.5 0.7 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Kinase-like PF14531.6 ETO20021.1 - 0.06 12.7 0.0 1.6 8.0 0.0 2.2 2 0 0 2 2 2 0 Kinase-like N_BRCA1_IG PF16158.5 ETO20022.1 - 4.3e-18 65.9 0.1 1.2e-17 64.5 0.1 1.7 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene PB1 PF00564.24 ETO20022.1 - 3.2e-11 43.0 0.0 6.3e-11 42.1 0.0 1.5 1 0 0 1 1 1 1 PB1 domain UBA PF00627.31 ETO20022.1 - 0.078 12.9 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 UBA/TS-N domain N_BRCA1_IG PF16158.5 ETO20023.1 - 4.2e-12 46.7 0.0 1e-11 45.4 0.0 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene UBA PF00627.31 ETO20023.1 - 0.00047 20.0 0.0 0.0012 18.7 0.0 1.7 1 0 0 1 1 1 1 UBA/TS-N domain ZZ PF00569.17 ETO20023.1 - 0.0012 18.6 1.0 0.0035 17.1 1.0 1.7 1 1 0 1 1 1 1 Zinc finger, ZZ type CARDB PF07705.11 ETO20023.1 - 0.014 15.6 0.0 0.037 14.3 0.0 1.7 1 0 0 1 1 1 0 CARDB DUF2207 PF09972.9 ETO20024.1 - 0.00057 18.8 0.8 0.00057 18.8 0.8 2.1 1 1 1 2 2 2 1 Predicted membrane protein (DUF2207) Herpes_US12 PF05363.12 ETO20024.1 - 0.025 15.3 0.1 0.025 15.3 0.1 2.3 3 0 0 3 3 3 0 Herpesvirus US12 family LAP1C PF05609.12 ETO20024.1 - 0.093 11.8 26.1 0.12 11.5 26.1 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dapper PF15268.6 ETO20024.1 - 0.23 10.3 29.6 0.29 10.0 29.6 1.0 1 0 0 1 1 1 0 Dapper Ndc1_Nup PF09531.10 ETO20024.1 - 0.88 8.2 13.9 1.1 7.9 13.9 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AF-4 PF05110.13 ETO20024.1 - 9 4.2 37.9 11 4.0 37.9 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein WW PF00397.26 ETO20025.1 - 3.1e-08 33.5 1.0 8.8e-08 32.1 1.0 1.9 1 0 0 1 1 1 1 WW domain DUF1515 PF07439.11 ETO20025.1 - 2 8.5 5.0 0.67 10.0 0.5 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) DUF4834 PF16118.5 ETO20026.1 - 0.025 15.5 0.1 0.52 11.3 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) SRP-alpha_N PF04086.13 ETO20027.1 - 0.057 13.3 28.5 0.072 13.0 28.5 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal AC_N PF16214.5 ETO20027.1 - 1.9 7.5 12.9 2.6 7.1 12.9 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region LAP1C PF05609.12 ETO20027.1 - 2.4 7.1 26.3 3.9 6.5 26.3 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_U57 PF05582.12 ETO20027.1 - 4.3 6.5 19.4 0.23 10.7 2.0 2.1 2 0 0 2 2 2 0 YabG peptidase U57 DUF4551 PF15087.6 ETO20027.1 - 4.5 6.0 11.2 5.1 5.8 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RTP1_C1 PF10363.9 ETO20028.1 - 0.012 15.8 0.1 0.024 14.8 0.1 1.5 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 UCH PF00443.29 ETO20028.1 - 0.21 11.1 0.3 0.29 10.6 0.3 1.2 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase HEAT PF02985.22 ETO20029.1 - 7.5e-11 41.3 0.0 0.097 13.0 0.1 6.0 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 ETO20029.1 - 7.6e-07 29.4 0.0 0.00073 19.9 0.0 4.1 2 1 2 5 5 5 2 HEAT repeats HEAT_EZ PF13513.6 ETO20029.1 - 3.4e-05 24.3 0.0 0.11 13.0 0.0 5.1 4 1 1 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO20029.1 - 0.00073 20.1 10.4 0.029 15.0 0.7 5.4 3 3 3 6 6 6 1 Vacuolar 14 Fab1-binding region Viral_cys_rich PF08008.12 ETO20029.1 - 0.0064 16.5 1.6 0.027 14.5 0.4 2.8 2 0 0 2 2 2 1 Viral cysteine rich mRNA_decap_C PF16741.5 ETO20029.1 - 0.064 12.6 0.1 0.064 12.6 0.1 4.8 5 1 0 5 5 5 0 mRNA-decapping enzyme C-terminus MEDS PF14417.6 ETO20029.1 - 0.12 12.2 0.0 2.5 7.9 0.0 2.6 1 1 1 2 2 2 0 MEDS: MEthanogen/methylotroph, DcmR Sensory domain DUF5388 PF17363.2 ETO20029.1 - 0.21 11.8 9.8 2.8 8.2 0.1 5.6 7 0 0 7 7 7 0 Family of unknown function (DUF5388) RTP1_C1 PF10363.9 ETO20029.1 - 1.1 9.4 10.1 1.1 9.5 0.7 4.3 2 1 3 5 5 5 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF445 PF04286.12 ETO20029.1 - 1.5 8.5 22.0 0.74 9.6 14.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF445) WD40 PF00400.32 ETO20032.1 - 1.9e-42 142.4 17.9 2.9e-10 40.6 0.1 7.5 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20032.1 - 1e-14 54.5 2.9 0.00061 20.0 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20032.1 - 5.2e-12 45.4 0.5 0.021 13.8 0.0 4.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO20032.1 - 1.5e-05 23.9 9.6 0.78 8.3 0.0 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO20032.1 - 1.9e-05 24.4 0.7 0.4 10.7 0.1 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO20032.1 - 0.00065 19.1 0.6 1 8.6 0.0 3.0 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO20032.1 - 0.0062 15.1 0.8 0.25 9.9 0.1 2.4 2 0 0 2 2 2 2 Cytochrome D1 heme domain ComK PF06338.11 ETO20032.1 - 0.1 12.2 1.7 1.7 8.3 0.1 2.9 3 0 0 3 3 3 0 ComK protein PA28_beta PF02252.18 ETO20033.1 - 5.1e-44 149.5 0.7 5.1e-44 149.5 0.7 1.5 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETO20033.1 - 0.037 14.1 0.7 0.097 12.7 0.7 1.7 1 0 0 1 1 1 0 Proteasome activator pa28 alpha subunit LCM PF04072.14 ETO20034.1 - 1.1e-11 45.1 0.0 6.9e-06 26.1 0.0 2.4 1 1 1 2 2 2 2 Leucine carboxyl methyltransferase Endostatin PF06482.11 ETO20035.1 - 0.029 13.8 7.3 0.036 13.5 7.3 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DNA_pol_phi PF04931.13 ETO20035.1 - 0.91 7.5 18.2 1 7.4 18.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi BORG_CEP PF14957.6 ETO20035.1 - 1.1 10.4 14.8 1.4 10.1 14.8 1.2 1 0 0 1 1 1 0 Cdc42 effector Trypan_PARP PF05887.11 ETO20035.1 - 2.2 8.3 23.9 3.2 7.7 23.9 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Presenilin PF01080.17 ETO20035.1 - 5 5.8 17.2 5.2 5.7 17.2 1.1 1 0 0 1 1 1 0 Presenilin CobT PF06213.12 ETO20035.1 - 5.1 6.4 21.1 5.4 6.3 21.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TCP PF03634.13 ETO20035.1 - 5.4 7.6 19.9 7.4 7.1 19.9 1.2 1 0 0 1 1 1 0 TCP family transcription factor VIR_N PF15912.5 ETO20035.1 - 6 6.4 17.7 7.3 6.1 17.7 1.0 1 0 0 1 1 1 0 Virilizer, N-terminal NPR3 PF03666.13 ETO20035.1 - 6.8 5.4 20.7 7.7 5.2 20.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO20035.1 - 8.6 5.5 14.3 9.2 5.4 14.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO20035.1 - 8.7 4.5 22.3 8.7 4.5 22.3 1.1 1 0 0 1 1 1 0 CDC45-like protein U79_P34 PF03064.16 ETO20035.1 - 8.8 5.6 24.2 9.9 5.4 24.2 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 DUF913 PF06025.12 ETO20035.1 - 9.1 5.1 15.3 11 4.9 15.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) MM_CoA_mutase PF01642.22 ETO20036.1 - 8.8e-14 50.9 1.3 9.4e-14 50.8 1.3 1.0 1 0 0 1 1 1 1 Methylmalonyl-CoA mutase MM_CoA_mutase PF01642.22 ETO20037.1 - 3.3e-93 313.0 1.7 4.4e-91 306.0 1.7 2.0 1 1 0 1 1 1 1 Methylmalonyl-CoA mutase Peptidase_C14 PF00656.22 ETO20038.1 - 1.3e-11 44.9 0.2 2.3e-11 44.2 0.2 1.4 1 0 0 1 1 1 1 Caspase domain AP4E_app_platf PF14807.6 ETO20039.1 - 0.077 13.4 1.8 13 6.2 0.1 3.5 3 0 0 3 3 3 0 Adaptin AP4 complex epsilon appendage platform DivIC PF04977.15 ETO20039.1 - 0.12 12.2 2.3 0.33 10.7 2.3 1.7 1 0 0 1 1 1 0 Septum formation initiator SIR4_SID PF16991.5 ETO20039.1 - 4.7 7.2 12.2 0.23 11.5 0.3 2.8 1 1 2 3 3 3 0 Sir4 SID domain IBB PF01749.20 ETO20040.1 - 5.6e-07 29.9 4.5 2e-06 28.2 3.9 2.2 2 1 0 2 2 2 1 Importin beta binding domain Arm PF00514.23 ETO20040.1 - 5.5e-06 26.2 0.0 0.013 15.5 0.0 3.0 2 1 0 2 2 2 2 Armadillo/beta-catenin-like repeat Presenilin PF01080.17 ETO20041.1 - 3.8 6.2 7.5 4.5 5.9 7.5 1.1 1 0 0 1 1 1 0 Presenilin PBP1_TM PF14812.6 ETO20041.1 - 4.8 7.6 7.6 5.2 7.5 6.4 1.7 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal F-box-like PF12937.7 ETO20042.1 - 3.3e-05 23.7 0.2 5.6e-05 22.9 0.2 1.3 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO20042.1 - 0.00079 19.2 0.2 0.0016 18.2 0.2 1.4 1 0 0 1 1 1 1 F-box domain PAS_3 PF08447.12 ETO20042.1 - 0.054 13.8 0.1 0.1 12.9 0.1 1.4 1 0 0 1 1 1 0 PAS fold Corazonin PF17308.2 ETO20042.1 - 2.4 8.5 10.2 2.3 8.6 8.7 1.7 1 1 0 1 1 1 0 Pro-corazonin CwfJ_C_1 PF04677.15 ETO20043.1 - 4.2e-11 42.8 8.8 1.3e-10 41.2 8.8 1.8 1 1 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 EMC3_TMCO1 PF01956.16 ETO20043.1 - 0.13 12.0 0.1 0.13 12.0 0.1 2.2 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CwfJ_C_2 PF04676.14 ETO20044.1 - 2.8e-14 53.8 0.6 5.6e-14 52.8 0.0 1.8 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 Ndc80_HEC PF03801.13 ETO20045.1 - 3.2e-36 124.3 0.1 8.4e-36 122.9 0.1 1.8 1 0 0 1 1 1 1 HEC/Ndc80p family MHB PF16525.5 ETO20045.1 - 0.023 15.0 0.1 0.12 12.7 0.1 2.2 2 0 0 2 2 2 0 Haemophore, haem-binding PH_12 PF16457.5 ETO20045.1 - 0.026 15.1 0.5 0.026 15.1 0.5 2.6 3 1 0 3 3 3 0 Pleckstrin homology domain Folate_rec PF03024.14 ETO20046.1 - 0.00034 20.5 6.0 0.00034 20.5 4.0 1.9 1 1 1 2 2 2 1 Folate receptor family Glucos_trans_II PF14264.6 ETO20046.1 - 0.73 9.1 9.5 0.048 13.0 1.8 2.0 2 0 0 2 2 2 0 Glucosyl transferase GtrII TFIIA PF03153.13 ETO20046.1 - 1 9.3 30.9 1.3 8.9 30.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Na_trans_assoc PF06512.13 ETO20046.1 - 1.9 8.7 20.6 4 7.7 20.6 1.6 1 0 0 1 1 1 0 Sodium ion transport-associated Sec7 PF01369.20 ETO20047.1 - 7.8e-32 110.4 0.5 9.4e-31 106.9 0.0 2.5 2 0 0 2 2 2 1 Sec7 domain DUF2464 PF10240.9 ETO20047.1 - 1.3e-08 34.8 0.0 1.3e-08 34.8 0.0 3.2 3 1 1 4 4 4 1 Multivesicular body subunit 12 PH_10 PF15411.6 ETO20047.1 - 0.33 11.2 0.0 0.33 11.2 0.0 2.7 3 0 0 3 3 3 0 Pleckstrin homology domain Menin PF05053.13 ETO20047.1 - 1.2 7.4 13.0 1.9 6.8 13.0 1.1 1 0 0 1 1 1 0 Menin Sec7_N PF12783.7 ETO20047.1 - 8 6.3 13.1 0.076 12.9 1.6 3.3 4 0 0 4 4 4 0 Guanine nucleotide exchange factor in Golgi transport N-terminal CBS PF00571.28 ETO20048.1 - 4.4e-16 59.1 0.0 2.3e-06 27.9 0.0 3.8 4 0 0 4 4 4 3 CBS domain MSC PF09402.10 ETO20050.1 - 0.035 13.6 0.1 0.059 12.8 0.1 1.4 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain NPR3 PF03666.13 ETO20052.1 - 0.00028 19.8 6.6 0.00028 19.8 6.6 3.3 3 1 0 3 3 3 1 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 ETO20052.1 - 0.0057 16.5 25.5 0.0057 16.5 25.5 3.2 1 1 1 3 3 3 1 Ryanodine Receptor TM 4-6 Nucleoside_tran PF01733.18 ETO20052.1 - 0.086 12.2 3.3 0.24 10.8 3.3 1.8 1 0 0 1 1 1 0 Nucleoside transporter Vma12 PF11712.8 ETO20052.1 - 0.63 10.1 4.0 3.6 7.6 4.0 2.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2052 PF09747.9 ETO20052.1 - 4.5 7.4 50.9 0.086 13.0 16.6 3.3 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) BUD22 PF09073.10 ETO20054.1 - 0.00043 19.7 24.0 0.0058 16.0 6.6 3.2 3 0 0 3 3 3 3 BUD22 Presenilin PF01080.17 ETO20054.1 - 1.8 7.3 22.3 0.13 11.0 10.0 3.0 3 0 0 3 3 3 0 Presenilin Peptidase_S49_N PF08496.10 ETO20054.1 - 6.3 6.8 16.1 36 4.4 0.1 2.6 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RPEL PF02755.15 ETO20055.1 - 8.5e-05 22.1 3.2 0.00028 20.5 1.8 2.3 2 0 0 2 2 2 1 RPEL repeat SWI-SNF_Ssr4 PF08549.10 ETO20055.1 - 0.018 13.7 14.3 0.02 13.5 14.3 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DUF2981 PF11200.8 ETO20055.1 - 1.2 8.9 16.9 1.4 8.6 16.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) RIFIN PF02009.16 ETO20055.1 - 3.2 7.6 7.1 4.1 7.2 7.1 1.2 1 0 0 1 1 1 0 Rifin Macoilin PF09726.9 ETO20055.1 - 6.7 5.1 28.0 8.9 4.7 28.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF508 PF04370.12 ETO20058.1 - 0.036 13.8 0.7 0.036 13.8 0.7 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF508) SR-25 PF10500.9 ETO20058.1 - 0.64 9.6 18.1 1 8.9 18.0 1.4 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 ETO20058.1 - 6.5 5.4 7.8 8.6 5.0 7.8 1.1 1 0 0 1 1 1 0 Presenilin TAFII55_N PF04658.13 ETO20059.1 - 0.015 15.0 0.5 0.024 14.4 0.5 1.2 1 0 0 1 1 1 0 TAFII55 protein conserved region DUF3682 PF12446.8 ETO20059.1 - 0.053 14.0 9.8 0.43 11.1 8.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) Peptidase_S49_N PF08496.10 ETO20059.1 - 0.14 12.2 2.4 0.2 11.7 2.4 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Roughex PF06020.11 ETO20059.1 - 2.2 7.3 4.9 2.9 6.9 4.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein STAT_alpha PF01017.20 ETO20060.1 - 0.04 13.8 0.1 0.067 13.1 0.1 1.4 1 0 0 1 1 1 0 STAT protein, all-alpha domain DEP PF00610.21 ETO20061.1 - 3.1e-10 40.0 0.1 5.4e-10 39.2 0.1 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) GREB1 PF15782.5 ETO20061.1 - 1.2 6.2 15.5 1.5 5.8 15.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4746 PF15928.5 ETO20061.1 - 7.9 5.8 16.7 2.4 7.5 7.9 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Pkinase PF00069.25 ETO20062.1 - 1.1e-64 218.4 0.6 1e-62 211.9 0.6 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20062.1 - 4.9e-30 104.7 0.2 2.1e-27 96.1 0.2 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO20062.1 - 0.0001 21.7 0.4 0.00026 20.4 0.4 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO20062.1 - 0.0018 17.3 0.5 0.0018 17.3 0.5 1.5 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ETO20062.1 - 0.0081 15.5 0.1 0.99 8.7 0.1 2.3 1 1 1 2 2 2 2 Kinase-like CAMSAP_CH PF11971.8 ETO20062.1 - 0.12 12.2 0.2 0.31 10.9 0.2 1.7 1 0 0 1 1 1 0 CAMSAP CH domain C1-set PF07654.15 ETO20063.1 - 0.95 9.9 7.3 0.79 10.1 2.1 2.5 2 0 0 2 2 2 0 Immunoglobulin C1-set domain FAM184 PF15665.5 ETO20064.1 - 0.00079 19.3 10.6 0.00079 19.3 10.6 2.0 1 1 1 2 2 2 1 Family with sequence similarity 184, A and B Lipoprotein_6 PF01441.19 ETO20064.1 - 0.0043 17.1 0.8 0.0056 16.7 0.8 1.1 1 0 0 1 1 1 1 Lipoprotein FlaC_arch PF05377.11 ETO20064.1 - 0.0065 16.8 7.1 5 7.6 0.0 4.4 2 1 1 4 4 4 1 Flagella accessory protein C (FlaC) Seryl_tRNA_N PF02403.22 ETO20064.1 - 0.0087 16.3 12.7 0.09 13.0 0.1 2.1 1 1 1 2 2 2 1 Seryl-tRNA synthetase N-terminal domain APG6_N PF17675.1 ETO20064.1 - 0.0098 16.4 19.9 0.0098 16.4 19.9 1.6 1 1 1 2 2 2 1 Apg6 coiled-coil region AAA_13 PF13166.6 ETO20064.1 - 0.018 13.7 8.1 0.021 13.5 8.1 1.1 1 0 0 1 1 1 0 AAA domain RE_TaqI PF09573.10 ETO20064.1 - 0.021 14.6 2.6 0.023 14.5 2.6 1.2 1 0 0 1 1 1 0 TaqI restriction endonuclease Atg14 PF10186.9 ETO20064.1 - 0.033 13.3 11.4 0.047 12.8 11.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Filament PF00038.21 ETO20064.1 - 0.041 13.5 18.4 0.3 10.6 0.4 2.7 1 1 1 2 2 2 0 Intermediate filament protein DUF1664 PF07889.12 ETO20064.1 - 0.057 13.5 11.1 0.09 12.8 1.4 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) KLRAQ PF10205.9 ETO20064.1 - 0.069 13.4 10.7 3.8 7.8 0.1 2.8 1 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein CENP-H PF05837.12 ETO20064.1 - 0.087 13.2 13.8 0.28 11.6 4.8 2.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) ABC1 PF03109.16 ETO20064.1 - 0.14 12.3 4.3 0.097 12.8 2.8 1.5 2 0 0 2 2 1 0 ABC1 family LPP PF04728.13 ETO20064.1 - 0.26 11.7 12.1 16 6.0 0.0 4.1 1 1 1 3 3 3 0 Lipoprotein leucine-zipper Golgin_A5 PF09787.9 ETO20064.1 - 0.65 9.4 21.1 0.97 8.8 18.4 2.0 1 1 1 2 2 2 0 Golgin subfamily A member 5 ADIP PF11559.8 ETO20064.1 - 0.69 10.0 15.9 0.046 13.8 4.2 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding FapA PF03961.13 ETO20064.1 - 1.1 7.8 11.9 2.1 6.9 10.3 1.9 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF1515 PF07439.11 ETO20064.1 - 1.1 9.3 9.0 0.28 11.2 2.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) FUSC PF04632.12 ETO20064.1 - 1.2 7.5 4.7 1.4 7.4 4.7 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family SKA1 PF07160.12 ETO20064.1 - 1.3 8.8 12.6 1.4 8.7 10.4 1.9 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 1 WXG100 PF06013.12 ETO20064.1 - 1.4 9.2 14.9 2.1 8.7 1.3 3.5 2 2 1 3 3 3 0 Proteins of 100 residues with WXG DUF4164 PF13747.6 ETO20064.1 - 1.4 9.2 10.7 3.7 7.9 6.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Fib_alpha PF08702.10 ETO20064.1 - 1.4 9.1 13.1 2.1 8.6 7.3 2.3 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Exonuc_VII_L PF02601.15 ETO20064.1 - 1.5 8.3 11.6 2.2 7.7 11.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit HemX PF04375.14 ETO20064.1 - 2.2 7.5 18.0 2.6 7.2 12.8 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF2203 PF09969.9 ETO20064.1 - 2.6 8.8 12.2 1e+03 0.4 12.2 2.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) PRKG1_interact PF15898.5 ETO20064.1 - 3 8.8 15.4 6.6 7.7 11.2 2.4 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain YabA PF06156.13 ETO20064.1 - 4.2 8.1 12.8 1e+02 3.6 10.6 2.9 1 1 1 2 2 2 0 Initiation control protein YabA DUF4200 PF13863.6 ETO20064.1 - 8.8 6.8 19.8 5.8 7.3 7.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) LMBR1 PF04791.16 ETO20064.1 - 9.8 4.9 10.8 12 4.7 10.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ALAD PF00490.21 ETO20065.1 - 5e-48 163.9 0.4 5.5e-48 163.8 0.4 1.0 1 0 0 1 1 1 1 Delta-aminolevulinic acid dehydratase G3P_antiterm PF04309.12 ETO20065.1 - 0.094 12.1 0.1 0.17 11.3 0.0 1.5 1 1 1 2 2 2 0 Glycerol-3-phosphate responsive antiterminator Patatin PF01734.22 ETO20066.1 - 8.2e-25 88.2 0.0 1.3e-24 87.6 0.0 1.3 1 0 0 1 1 1 1 Patatin-like phospholipase DEAD PF00270.29 ETO20067.1 - 4.8e-51 173.0 0.0 1.3e-50 171.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO20067.1 - 4.1e-26 91.5 0.0 3.8e-25 88.4 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain SecA_DEAD PF07517.14 ETO20067.1 - 0.0068 15.7 0.0 0.0068 15.7 0.0 2.8 3 1 0 3 3 3 1 SecA DEAD-like domain AAA_30 PF13604.6 ETO20067.1 - 0.031 14.0 0.0 0.1 12.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain DUF5612 PF18462.1 ETO20067.1 - 0.042 13.6 0.1 0.18 11.6 0.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5612) Auxin_canalis PF05703.11 ETO20067.1 - 1.4 8.8 6.7 2.5 8.0 6.7 1.4 1 0 0 1 1 1 0 Auxin canalisation Neur_chan_memb PF02932.16 ETO20067.1 - 1.5 8.8 8.9 3 7.8 8.9 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO20068.1 - 2.2 7.0 4.0 2.9 6.6 4.0 1.2 1 0 0 1 1 1 0 Presenilin Gemini_mov PF01708.16 ETO20069.1 - 0.026 14.3 0.1 0.15 11.9 0.0 2.1 2 0 0 2 2 2 0 Geminivirus putative movement protein WD40 PF00400.32 ETO20070.1 - 0.02 15.8 1.3 0.038 14.9 0.3 1.9 2 1 0 2 2 2 0 WD domain, G-beta repeat DUF1299 PF06975.11 ETO20070.1 - 0.044 13.8 0.1 0.066 13.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1299) DUF3637 PF12337.8 ETO20070.1 - 0.099 13.0 0.2 0.14 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3637) RVT_1 PF00078.27 ETO20071.1 - 6e-37 127.3 0.0 1.4e-36 126.1 0.0 1.7 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos_2 PF14529.6 ETO20071.1 - 4.3e-10 39.5 0.0 1.7e-09 37.6 0.0 2.2 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO20071.1 - 0.017 14.6 0.0 0.029 13.9 0.0 1.3 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Comm PF15957.5 ETO20072.1 - 0.2 12.0 1.9 0.33 11.3 1.8 1.5 1 1 0 1 1 1 0 Commissureless UCH_N PF16674.5 ETO20074.1 - 0.025 14.5 2.4 0.038 13.9 2.4 1.4 1 0 0 1 1 1 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 cNMP_binding PF00027.29 ETO20076.1 - 2.2e-07 30.8 0.0 1.1e-06 28.5 0.0 2.1 1 1 1 2 2 2 1 Cyclic nucleotide-binding domain Popeye PF04831.13 ETO20076.1 - 2.9e-07 30.7 2.1 6.9e-07 29.5 1.9 1.8 1 1 0 1 1 1 1 Popeye protein conserved region NEL PF14496.6 ETO20076.1 - 0.13 11.7 0.0 0.2 11.0 0.0 1.2 1 0 0 1 1 1 0 C-terminal novel E3 ligase, LRR-interacting Alba PF01918.21 ETO20077.1 - 5.8e-17 61.3 0.1 9.7e-17 60.6 0.1 1.4 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 ETO20077.1 - 0.00021 21.3 3.8 0.00033 20.6 3.8 1.6 1 1 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P KBP_C PF12309.8 ETO20077.1 - 0.36 10.3 2.4 0.43 10.1 2.4 1.1 1 0 0 1 1 1 0 KIF-1 binding protein C terminal Hat1_N PF10394.9 ETO20078.1 - 1.7e-25 90.2 2.2 2.3e-25 89.7 2.2 1.2 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Hat1_N PF10394.9 ETO20079.1 - 7.3e-07 29.6 2.0 8.4e-07 29.4 0.4 1.9 2 0 0 2 2 2 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 ETO20079.1 - 0.13 12.5 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family tRNA-synt_1e PF01406.19 ETO20080.1 - 1.2e-56 192.4 9.1 1.2e-56 192.4 9.1 2.4 2 1 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Peptidase_M74 PF03411.13 ETO20080.1 - 0.014 15.0 0.1 1.3 8.5 0.1 2.4 2 0 0 2 2 2 0 Penicillin-insensitive murein endopeptidase DALR_2 PF09190.11 ETO20080.1 - 0.024 15.1 1.9 0.77 10.3 0.0 3.9 4 0 0 4 4 4 0 DALR domain DUF5623 PF18536.1 ETO20080.1 - 0.046 14.0 0.4 0.13 12.6 0.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF5623) DUF3216 PF11505.8 ETO20080.1 - 0.076 13.2 0.8 0.53 10.5 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3216) DUF5532 PF17673.1 ETO20080.1 - 0.083 12.9 3.7 2.8 8.0 0.0 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5532) ZnuA PF01297.17 ETO20080.1 - 1.2 8.5 5.1 0.22 10.9 0.2 2.2 2 1 0 3 3 3 0 Zinc-uptake complex component A periplasmic FragX_IP PF05994.11 ETO20081.1 - 3.2e-17 61.9 0.1 3.2e-17 61.9 0.1 2.1 2 0 0 2 2 2 1 Cytoplasmic Fragile-X interacting family Coilin_N PF15862.5 ETO20081.1 - 2.3e-05 24.2 3.5 2.3e-05 24.2 3.5 1.9 1 1 1 2 2 2 1 Coilin N-terminus UPF0564 PF10595.9 ETO20081.1 - 0.00017 20.8 22.0 0.00023 20.4 22.0 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0564 PA26 PF04636.13 ETO20081.1 - 0.007 15.3 4.2 0.0096 14.9 4.2 1.4 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) DDHD PF02862.17 ETO20081.1 - 0.016 15.4 4.5 0.022 14.9 4.5 1.3 1 0 0 1 1 1 0 DDHD domain Borrelia_P83 PF05262.11 ETO20081.1 - 0.017 13.6 17.0 0.021 13.3 17.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein CDC45 PF02724.14 ETO20081.1 - 0.02 13.2 13.4 0.023 13.0 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Moulting_cycle PF04870.16 ETO20081.1 - 0.033 13.5 18.0 0.048 12.9 18.0 1.2 1 0 0 1 1 1 0 Moulting cycle Tim54 PF11711.8 ETO20081.1 - 0.048 12.4 13.1 0.076 11.8 13.1 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SLC12 PF03522.15 ETO20081.1 - 0.053 12.6 11.2 0.062 12.3 11.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 ETO20081.1 - 0.064 13.2 8.8 0.083 12.9 8.8 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 ETO20081.1 - 0.089 11.2 2.8 0.11 10.9 2.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 GAGA_bind PF06217.12 ETO20081.1 - 0.12 12.6 10.1 0.17 12.1 10.1 1.3 1 0 0 1 1 1 0 GAGA binding protein-like family NPR3 PF03666.13 ETO20081.1 - 0.17 10.7 12.3 0.26 10.0 12.3 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO20081.1 - 0.17 11.0 5.0 0.2 10.8 5.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter XRN_M PF17846.1 ETO20081.1 - 0.2 10.5 12.2 0.3 10.0 12.2 1.2 1 0 0 1 1 1 0 Xrn1 helical domain PAT1 PF09770.9 ETO20081.1 - 0.23 9.7 17.7 0.29 9.4 17.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Presenilin PF01080.17 ETO20081.1 - 0.25 10.1 15.9 0.33 9.7 15.9 1.2 1 0 0 1 1 1 0 Presenilin DUF2052 PF09747.9 ETO20081.1 - 0.28 11.3 21.1 0.45 10.6 21.1 1.3 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) MMR1 PF08505.10 ETO20081.1 - 0.37 11.1 12.9 0.47 10.7 12.9 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein DUF4569 PF15133.6 ETO20081.1 - 0.43 10.3 14.6 0.74 9.5 14.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Neur_chan_memb PF02932.16 ETO20081.1 - 0.46 10.5 10.5 0.75 9.8 10.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4045 PF13254.6 ETO20081.1 - 0.57 9.8 16.2 0.79 9.3 16.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) TP53IP5 PF15331.6 ETO20081.1 - 0.89 9.7 12.9 1.5 9.0 12.9 1.4 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 BORG_CEP PF14957.6 ETO20081.1 - 0.9 10.7 8.0 1.4 10.1 8.0 1.4 1 0 0 1 1 1 0 Cdc42 effector NARP1 PF12569.8 ETO20081.1 - 1.3 7.8 25.2 0.27 10.1 21.7 1.6 2 0 0 2 2 2 0 NMDA receptor-regulated protein 1 TMEM214 PF10151.9 ETO20081.1 - 1.5 7.2 16.2 2.4 6.5 16.2 1.4 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator DUF913 PF06025.12 ETO20081.1 - 1.5 7.7 8.6 2.2 7.2 8.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Membralin PF09746.9 ETO20081.1 - 1.5 7.8 9.6 2 7.4 9.6 1.2 1 0 0 1 1 1 0 Tumour-associated protein Otopetrin PF03189.13 ETO20081.1 - 1.6 7.5 5.1 1.9 7.2 5.1 1.1 1 0 0 1 1 1 0 Otopetrin CCSAP PF15748.5 ETO20081.1 - 1.8 8.7 20.6 2.7 8.1 20.6 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated IHABP4_N PF16174.5 ETO20081.1 - 2 9.0 27.8 3.1 8.4 27.8 1.2 1 0 0 1 1 1 0 Intracellular hyaluronan-binding protein 4 N-terminal PTPRCAP PF15713.5 ETO20081.1 - 2 8.7 24.7 3.1 8.1 24.7 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Ndc1_Nup PF09531.10 ETO20081.1 - 2.1 7.0 4.9 2.4 6.7 4.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Hid1 PF12722.7 ETO20081.1 - 2.5 6.1 13.6 3.4 5.7 13.6 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RP-C_C PF11800.8 ETO20081.1 - 2.8 8.0 10.9 4.8 7.2 10.9 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region FAM176 PF14851.6 ETO20081.1 - 3.1 7.5 13.6 4.8 6.8 12.7 1.8 2 0 0 2 2 1 0 FAM176 family Pex24p PF06398.11 ETO20081.1 - 3.3 6.6 7.9 5.1 6.0 7.9 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin Rtf2 PF04641.12 ETO20081.1 - 3.7 6.8 23.4 6.7 6.0 23.4 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger DUF4661 PF15576.6 ETO20081.1 - 4.8 7.0 7.2 7.3 6.4 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Cellulose_synt PF03552.14 ETO20081.1 - 6.6 5.1 8.6 8.9 4.7 8.6 1.1 1 0 0 1 1 1 0 Cellulose synthase Pannexin_like PF12534.8 ETO20081.1 - 7.8 5.5 11.6 12 4.9 11.6 1.3 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Tfb4 PF03850.14 ETO20081.1 - 8.3 5.8 9.3 62 2.9 0.0 2.2 2 0 0 2 2 2 0 Transcription factor Tfb4 CobT PF06213.12 ETO20081.1 - 8.5 5.7 25.3 12 5.2 25.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Vfa1 PF08432.10 ETO20081.1 - 9.5 6.5 26.3 17 5.7 26.3 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 UBA PF00627.31 ETO20082.1 - 0.0022 17.9 0.4 0.0067 16.3 0.0 2.1 3 0 0 3 3 3 1 UBA/TS-N domain Nop25 PF09805.9 ETO20082.1 - 1.2 9.6 16.7 0.12 12.8 5.8 2.1 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) SOBP PF15279.6 ETO20082.1 - 4.4 7.8 8.4 5.6 7.5 8.4 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4050 PF13259.6 ETO20082.1 - 6.5 7.0 13.6 52 4.1 13.6 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF4050) MscS_porin PF12795.7 ETO20083.1 - 0.0032 17.0 3.7 0.9 9.0 1.7 2.1 2 0 0 2 2 2 2 Mechanosensitive ion channel porin domain Cro PF09048.10 ETO20083.1 - 0.056 13.5 0.0 0.24 11.4 0.0 1.9 2 0 0 2 2 2 0 Cro Spc24 PF08286.11 ETO20083.1 - 0.12 12.7 4.7 0.86 9.9 1.0 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 KASH_CCD PF14662.6 ETO20083.1 - 0.42 10.4 6.1 0.13 12.1 2.2 1.8 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH MscS_TM PF12794.7 ETO20084.1 - 0.0099 14.8 1.9 0.016 14.1 0.0 1.8 1 1 1 2 2 2 1 Mechanosensitive ion channel inner membrane domain 1 BatD PF13584.6 ETO20084.1 - 0.049 12.4 0.4 0.059 12.2 0.4 1.1 1 0 0 1 1 1 0 Oxygen tolerance CpeS PF09367.10 ETO20084.1 - 0.079 12.9 0.4 0.13 12.2 0.4 1.3 1 0 0 1 1 1 0 CpeS-like protein OAD_gamma PF04277.13 ETO20084.1 - 0.098 13.3 4.0 2.2 8.9 0.0 2.2 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Sugar_tr PF00083.24 ETO20084.1 - 0.19 10.5 0.2 0.23 10.3 0.0 1.4 1 1 0 1 1 1 0 Sugar (and other) transporter UPF0542 PF15086.6 ETO20084.1 - 1.1 9.2 0.0 1.1 9.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 MIT PF04212.18 ETO20085.1 - 4.8e-09 36.2 8.3 3.3e-08 33.5 8.3 2.2 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain Glu-tRNAGln PF02686.15 ETO20085.1 - 0.043 14.1 1.3 0.97 9.8 0.0 2.4 2 0 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit DUF4407 PF14362.6 ETO20085.1 - 0.065 12.6 5.2 0.087 12.2 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4618 PF15397.6 ETO20085.1 - 0.16 11.4 10.4 0.22 10.9 10.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) AAA_11 PF13086.6 ETO20085.1 - 0.31 10.8 5.8 0.41 10.4 5.8 1.1 1 0 0 1 1 1 0 AAA domain Syntaxin_2 PF14523.6 ETO20085.1 - 0.46 10.9 6.2 1.9 8.9 5.9 1.9 1 1 0 1 1 1 0 Syntaxin-like protein DUF883 PF05957.13 ETO20085.1 - 0.6 10.7 3.1 19 5.9 0.0 2.4 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF4404 PF14357.6 ETO20085.1 - 0.79 10.4 11.1 7.5 7.3 6.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) DUF5320 PF17253.2 ETO20085.1 - 1.4 10.0 6.8 0.75 10.9 0.7 2.5 2 1 0 2 2 2 0 Family of unknown function (DUF5320) DUF4175 PF13779.6 ETO20085.1 - 1.7 6.4 8.5 2.2 6.1 8.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) HSP70 PF00012.20 ETO20085.1 - 2 6.5 9.4 2.4 6.2 9.4 1.0 1 0 0 1 1 1 0 Hsp70 protein FH2 PF02181.23 ETO20086.1 - 1.3e-45 156.1 5.7 1.5e-45 155.9 5.7 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain TAF PF02969.17 ETO20087.1 - 1.6e-06 28.2 0.3 1.6e-06 28.2 0.3 2.0 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) PGA2 PF07543.12 ETO20087.1 - 0.0041 17.1 4.1 0.0053 16.7 4.1 1.2 1 0 0 1 1 1 1 Protein trafficking PGA2 zinc_ribbon_11 PF11682.8 ETO20087.1 - 0.053 13.5 0.3 0.066 13.2 0.3 1.3 1 0 0 1 1 1 0 Probable zinc-ribbon DDHD PF02862.17 ETO20087.1 - 0.19 11.9 5.4 0.21 11.7 5.4 1.1 1 0 0 1 1 1 0 DDHD domain DUF4746 PF15928.5 ETO20087.1 - 0.26 10.7 5.9 0.34 10.3 5.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CCDC53 PF10152.9 ETO20087.1 - 0.31 11.4 5.8 0.38 11.1 5.8 1.1 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF5629 PF18629.1 ETO20088.1 - 0.087 13.4 0.5 0.39 11.3 0.1 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5629) WD40 PF00400.32 ETO20091.1 - 1.1e-35 121.0 12.6 4.5e-10 39.9 0.5 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20091.1 - 1.2e-11 44.7 0.5 0.0037 17.5 0.0 3.7 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20091.1 - 1.6e-08 33.9 0.3 0.12 11.3 0.0 3.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO20091.1 - 1.9e-05 23.4 0.1 0.15 10.6 0.0 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO20091.1 - 0.00032 20.1 0.1 0.0047 16.3 0.0 2.2 1 1 1 2 2 2 1 WD40-like domain PD40 PF07676.12 ETO20091.1 - 0.00075 19.4 1.3 3.8 7.6 0.0 3.9 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO20091.1 - 0.00075 18.3 7.6 0.46 9.1 0.0 3.8 2 2 2 4 4 4 3 Nucleoporin Nup120/160 ArlS_N PF18719.1 ETO20091.1 - 0.0034 17.6 0.1 2.5 8.3 0.0 3.3 2 1 1 3 3 3 1 ArlS sensor domain SGL PF08450.12 ETO20091.1 - 0.0052 16.4 0.1 0.32 10.5 0.1 2.3 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region DPPIV_N PF00930.21 ETO20091.1 - 0.008 15.0 0.1 0.47 9.1 0.0 3.1 1 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_2 PF13360.6 ETO20091.1 - 0.046 13.3 0.1 7 6.1 0.2 2.1 2 0 0 2 2 2 0 PQQ-like domain DUF5570 PF17731.1 ETO20091.1 - 0.05 13.7 2.9 13 5.9 0.0 3.7 2 2 2 4 4 4 0 Family of unknown function (DUF5570) Str_synth PF03088.16 ETO20091.1 - 0.057 13.6 0.0 1 9.5 0.0 2.6 2 0 0 2 2 2 0 Strictosidine synthase DUF1513 PF07433.11 ETO20091.1 - 0.066 12.3 0.3 1.5 7.8 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETO20091.1 - 1.1 9.0 4.5 7.8 6.3 0.1 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Myosin_head PF00063.21 ETO20092.1 - 6.5e-56 189.9 3.7 7.9e-56 189.6 3.7 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) CdvA PF18822.1 ETO20093.1 - 0.01 15.7 4.2 0.031 14.1 4.2 1.8 1 1 0 1 1 1 1 CdvA-like coiled-coil domain DUF148 PF02520.17 ETO20093.1 - 0.029 14.5 4.0 0.51 10.5 0.8 2.2 2 0 0 2 2 2 0 Domain of unknown function DUF148 MetOD2 PF18548.1 ETO20093.1 - 0.087 12.9 3.2 0.2 11.8 2.7 1.8 2 0 0 2 2 2 0 Metanogen output domain 2 Lectin_like PF18560.1 ETO20093.1 - 0.092 12.9 0.4 0.13 12.4 0.4 1.3 1 0 0 1 1 1 0 Lectin like domain COG2 PF06148.11 ETO20093.1 - 0.19 11.8 3.3 0.53 10.4 3.2 1.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 RRM_1 PF00076.22 ETO20095.1 - 2.8e-11 43.1 0.1 4.2e-11 42.5 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO20095.1 - 0.0094 16.0 0.2 0.014 15.4 0.2 1.3 1 0 0 1 1 1 1 RNA binding motif Telomere_reg-2 PF10193.9 ETO20096.1 - 0.14 12.6 0.0 0.16 12.4 0.0 1.2 1 0 0 1 1 1 0 Telomere length regulation protein CEP63 PF17045.5 ETO20097.1 - 0.0066 16.4 2.6 0.0066 16.4 2.6 2.4 2 1 0 2 2 2 1 Centrosomal protein of 63 kDa GRIP PF01465.20 ETO20097.1 - 0.02 14.8 2.8 0.14 12.0 0.0 3.2 3 0 0 3 3 3 0 GRIP domain Myc-LZ PF02344.15 ETO20097.1 - 0.063 13.4 1.0 0.063 13.4 1.0 4.2 4 1 0 4 4 4 0 Myc leucine zipper domain Golgin_A5 PF09787.9 ETO20097.1 - 0.073 12.5 46.6 0.14 11.6 7.3 3.4 2 1 1 3 3 3 0 Golgin subfamily A member 5 Bacillus_HBL PF05791.11 ETO20097.1 - 0.83 9.5 20.6 0.034 14.0 7.0 3.3 2 2 1 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) Peptidase_S10 PF00450.22 ETO20098.1 - 2.2e-32 113.0 1.3 2.5e-32 112.8 1.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase SET_assoc PF11767.8 ETO20098.1 - 0.056 13.1 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Histone lysine methyltransferase SET associated Cellulase PF00150.18 ETO20099.1 - 4.1e-16 59.2 0.0 5.5e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) AAA_7 PF12775.7 ETO20100.1 - 5.5e-60 202.0 0.0 2.4e-59 199.9 0.0 1.9 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_8 PF12780.7 ETO20100.1 - 7.3e-36 123.8 0.0 1.7e-35 122.6 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 Dynein_AAA_lid PF17852.1 ETO20100.1 - 1.4e-17 64.0 0.1 4.6e-17 62.3 0.1 1.9 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain AAA_5 PF07728.14 ETO20100.1 - 1.4e-09 38.0 0.0 4.1e-05 23.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_lid_1 PF17857.1 ETO20100.1 - 2.3e-07 30.9 0.0 8.4e-07 29.1 0.0 2.0 1 0 0 1 1 1 1 AAA+ lid domain DUF815 PF05673.13 ETO20100.1 - 0.00014 21.1 0.0 0.048 12.8 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF815) AAA_16 PF13191.6 ETO20100.1 - 0.00016 22.1 0.1 0.22 11.9 0.0 3.8 3 1 1 4 4 4 1 AAA ATPase domain AAA_22 PF13401.6 ETO20100.1 - 0.0013 19.0 0.4 0.12 12.7 0.0 3.0 2 1 1 3 3 3 1 AAA domain ATPase PF06745.13 ETO20100.1 - 0.0075 15.6 0.0 0.17 11.2 0.0 2.4 2 0 0 2 2 2 1 KaiC T2SSE PF00437.20 ETO20100.1 - 0.044 12.8 0.0 2.4 7.2 0.0 2.2 2 0 0 2 2 2 0 Type II/IV secretion system protein TrwB_AAD_bind PF10412.9 ETO20100.1 - 0.076 11.9 0.0 0.14 11.0 0.0 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_29 PF13555.6 ETO20100.1 - 0.12 12.1 0.0 11 5.8 0.0 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ETO20100.1 - 0.13 12.0 0.0 1.5 8.5 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_8 PF12780.7 ETO20101.1 - 1.9e-17 63.5 9.2 5e-17 62.1 2.7 3.1 3 1 0 3 3 3 1 P-loop containing dynein motor region D4 MT PF12777.7 ETO20101.1 - 2e-17 63.3 8.5 3e-17 62.7 8.5 1.2 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor SlyX PF04102.12 ETO20101.1 - 0.11 13.2 1.2 0.34 11.5 1.2 1.9 1 0 0 1 1 1 0 SlyX DUF1664 PF07889.12 ETO20101.1 - 0.23 11.5 6.4 0.32 11.0 5.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 ETO20101.1 - 0.8 10.2 10.2 4.9 7.7 10.2 2.3 1 1 0 1 1 1 0 Protein of unknown function DUF16 Atg14 PF10186.9 ETO20101.1 - 1.1 8.3 10.6 1.6 7.7 10.6 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MCC-bdg_PDZ PF10506.9 ETO20101.1 - 2.4 8.2 6.0 12 6.0 0.1 2.8 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome AAA_9 PF12781.7 ETO20102.1 - 1.5e-87 292.4 0.9 8.7e-85 283.3 1.1 2.5 2 0 0 2 2 2 2 ATP-binding dynein motor region Dynein_C PF18199.1 ETO20102.1 - 5.2e-87 291.9 0.9 5.2e-87 291.9 0.9 2.6 3 0 0 3 3 3 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETO20102.1 - 6.8e-54 182.1 0.6 1.5e-53 181.0 0.6 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ETO20102.1 - 2.7e-43 146.8 0.0 1.5e-42 144.4 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain MT PF12777.7 ETO20102.1 - 5.8e-07 28.9 0.0 5.8e-07 28.9 0.0 1.6 2 0 0 2 2 2 1 Microtubule-binding stalk of dynein motor ATPase PF06745.13 ETO20102.1 - 1 8.6 3.6 1.9 7.7 0.8 2.2 2 0 0 2 2 2 0 KaiC MRPL52 PF18699.1 ETO20104.1 - 0.0023 18.1 3.9 0.004 17.3 3.5 1.6 1 1 0 1 1 1 1 Mitoribosomal protein mL52 FlxA PF14282.6 ETO20104.1 - 3.2 7.8 11.4 1 9.4 4.9 2.4 2 0 0 2 2 2 0 FlxA-like protein SDA1 PF05285.12 ETO20105.1 - 1.1e-06 28.3 14.4 1.7e-06 27.7 14.4 1.2 1 0 0 1 1 1 1 SDA1 Mpp10 PF04006.12 ETO20105.1 - 0.00051 18.6 18.8 0.0007 18.2 18.8 1.1 1 0 0 1 1 1 1 Mpp10 protein SAPS PF04499.15 ETO20105.1 - 0.00082 18.3 10.9 0.0071 15.2 6.9 2.2 2 0 0 2 2 2 2 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO20105.1 - 0.003 15.9 17.0 0.005 15.2 17.0 1.3 1 0 0 1 1 1 1 CDC45-like protein Merozoite_SPAM PF07133.11 ETO20105.1 - 0.014 15.4 38.6 0.027 14.5 38.6 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) SpoIIIAH PF12685.7 ETO20105.1 - 0.025 14.4 14.2 0.041 13.7 14.2 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein O-antigen_lig PF13425.6 ETO20105.1 - 0.072 11.9 5.4 0.01 14.6 1.1 1.7 2 0 0 2 2 2 0 O-antigen ligase like membrane protein CobT PF06213.12 ETO20105.1 - 0.091 12.1 19.6 0.13 11.6 19.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF913 PF06025.12 ETO20105.1 - 0.17 10.8 5.0 0.34 9.8 5.0 1.5 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Vfa1 PF08432.10 ETO20105.1 - 0.17 12.2 16.5 0.46 10.8 16.5 1.7 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Nop14 PF04147.12 ETO20105.1 - 0.21 9.8 26.4 0.31 9.2 26.4 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO20105.1 - 0.25 10.1 9.4 0.36 9.5 9.4 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO20105.1 - 0.31 10.2 7.7 0.45 9.7 7.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BUD22 PF09073.10 ETO20105.1 - 0.36 10.1 20.2 0.53 9.6 20.2 1.2 1 0 0 1 1 1 0 BUD22 ALMT PF11744.8 ETO20105.1 - 1.5 7.5 6.6 2.4 6.9 6.6 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter TFIIF_alpha PF05793.12 ETO20105.1 - 1.7 7.2 30.7 2.4 6.7 30.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_11 PF13086.6 ETO20105.1 - 2.3 7.9 7.7 0.29 10.9 3.4 1.7 2 0 0 2 2 2 0 AAA domain RP-C_C PF11800.8 ETO20105.1 - 7.2 6.7 6.6 12 5.9 6.6 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region VESA1_N PF12785.7 ETO20107.1 - 0.015 14.3 0.4 0.019 14.0 0.4 1.1 1 0 0 1 1 1 0 Variant erythrocyte surface antigen-1 GET2 PF08690.10 ETO20108.1 - 0.38 10.4 2.7 0.42 10.3 1.0 1.8 2 0 0 2 2 2 0 GET complex subunit GET2 FKBP_C PF00254.28 ETO20110.1 - 2.8e-06 27.6 0.1 5.9e-06 26.5 0.0 1.6 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase DUF294_C PF10335.9 ETO20111.1 - 9.7e-05 22.2 0.4 0.00035 20.4 0.0 2.1 2 0 0 2 2 2 1 Putative nucleotidyltransferase substrate binding domain DUF4834 PF16118.5 ETO20112.1 - 2.4 9.2 0.0 2.4 9.2 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Fer4_22 PF17179.4 ETO20113.1 - 0.54 11.1 2.2 0.79 10.6 2.2 1.2 1 0 0 1 1 1 0 4Fe-4S dicluster domain Lebercilin PF15619.6 ETO20114.1 - 0.011 15.5 9.7 0.22 11.2 3.2 2.1 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Peptidase_C6 PF00851.18 ETO20114.1 - 0.028 13.4 1.2 0.035 13.1 1.2 1.1 1 0 0 1 1 1 0 Helper component proteinase DUF745 PF05335.13 ETO20114.1 - 0.15 11.8 5.6 0.11 12.2 1.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF745) XhlA PF10779.9 ETO20114.1 - 1.5 9.1 7.8 46 4.3 6.1 2.6 2 1 0 2 2 2 0 Haemolysin XhlA FKBP_C PF00254.28 ETO20115.1 - 1.8e-13 50.6 0.2 4.3e-13 49.4 0.0 1.7 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase Ribosomal_60s PF00428.19 ETO20115.1 - 0.049 14.2 1.2 0.094 13.3 1.2 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein Wtap PF17098.5 ETO20116.1 - 0.00013 22.0 0.9 0.00023 21.1 0.9 1.4 1 0 0 1 1 1 1 WTAP/Mum2p family Rootletin PF15035.6 ETO20116.1 - 0.00097 19.2 2.4 0.0016 18.5 2.4 1.3 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion DivIC PF04977.15 ETO20116.1 - 0.0012 18.5 3.6 0.0012 18.5 3.6 2.9 2 1 1 3 3 3 1 Septum formation initiator bZIP_1 PF00170.21 ETO20116.1 - 0.0025 17.9 9.4 0.024 14.7 3.7 2.6 1 1 1 2 2 2 1 bZIP transcription factor TMF_TATA_bd PF12325.8 ETO20116.1 - 0.0051 17.0 4.8 0.0051 17.0 4.8 1.7 2 0 0 2 2 1 1 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.6 ETO20116.1 - 0.0058 16.5 9.0 0.012 15.5 9.0 1.4 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Phage_GP20 PF06810.11 ETO20116.1 - 0.043 13.6 6.3 0.086 12.6 6.3 1.4 1 0 0 1 1 1 0 Phage minor structural protein GP20 YabA PF06156.13 ETO20116.1 - 0.046 14.4 5.5 0.16 12.7 5.5 1.9 1 0 0 1 1 1 0 Initiation control protein YabA DUF3394 PF11874.8 ETO20116.1 - 0.054 13.2 2.3 3.9 7.1 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3394) Hormone_1 PF00103.20 ETO20116.1 - 0.054 13.2 0.4 0.092 12.5 0.4 1.4 1 0 0 1 1 1 0 Somatotropin hormone family bZIP_2 PF07716.15 ETO20116.1 - 0.067 13.3 12.7 0.59 10.3 4.5 2.6 2 0 0 2 2 2 0 Basic region leucine zipper YpjP PF14005.6 ETO20116.1 - 0.074 13.1 2.5 0.081 13.0 1.0 1.8 2 0 0 2 2 1 0 YpjP-like protein PDZ PF00595.24 ETO20116.1 - 0.087 13.2 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 PDZ domain HALZ PF02183.18 ETO20116.1 - 0.14 12.4 4.3 1.2 9.5 1.0 3.1 2 0 0 2 2 2 0 Homeobox associated leucine zipper DUF2205 PF10224.9 ETO20116.1 - 0.16 12.0 4.4 0.98 9.5 2.0 3.0 2 1 2 4 4 4 0 Short coiled-coil protein EF-hand_14 PF17959.1 ETO20116.1 - 0.18 12.1 1.8 0.44 10.9 1.8 1.6 1 0 0 1 1 1 0 EF-hand domain FlaC_arch PF05377.11 ETO20116.1 - 0.19 12.1 6.7 1.3 9.5 1.1 3.0 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Fungal_TACC PF12709.7 ETO20116.1 - 0.24 11.9 6.5 0.29 11.6 4.6 2.2 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins Fib_alpha PF08702.10 ETO20116.1 - 0.26 11.4 4.3 0.6 10.3 4.3 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Shugoshin_N PF07558.11 ETO20116.1 - 0.31 10.9 5.7 9.7 6.1 0.4 2.9 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region GIT_CC PF16559.5 ETO20116.1 - 0.35 10.8 7.5 0.98 9.3 0.8 2.8 1 1 2 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor TSC22 PF01166.18 ETO20116.1 - 0.36 11.2 11.7 1.3 9.3 3.2 2.8 2 1 0 3 3 2 0 TSC-22/dip/bun family DUF2570 PF10828.8 ETO20116.1 - 0.53 10.1 5.2 1.3 8.9 5.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2570) APG6_N PF17675.1 ETO20116.1 - 0.54 10.8 10.9 0.08 13.5 6.2 2.0 2 0 0 2 2 2 0 Apg6 coiled-coil region APC_N_CC PF16689.5 ETO20116.1 - 3.1 7.9 7.2 11 6.1 6.5 2.4 1 1 1 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain SlyX PF04102.12 ETO20116.1 - 4.1 8.1 6.1 1.8 9.2 1.2 2.4 1 1 1 2 2 2 0 SlyX ZapB PF06005.12 ETO20116.1 - 5.3 7.6 13.3 72 3.9 13.3 2.6 1 1 0 1 1 1 0 Cell division protein ZapB DUF1129 PF06570.11 ETO20117.1 - 0.016 14.7 0.2 0.03 13.8 0.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1129) PT PF04886.12 ETO20118.1 - 1.8e-103 337.8 527.0 1e-07 31.4 16.6 24.7 1 1 17 18 18 18 14 PT repeat Nop14 PF04147.12 ETO20119.1 - 0.0012 17.1 14.7 0.0012 17.1 14.7 2.1 2 0 0 2 2 2 1 Nop14-like family CAP_GLY PF01302.25 ETO20120.1 - 1.3e-23 82.7 4.5 1.8e-14 53.5 0.6 2.5 2 0 0 2 2 2 2 CAP-Gly domain Ribosomal_L14 PF00238.19 ETO20120.1 - 0.082 13.0 2.4 5 7.2 1.8 2.5 2 0 0 2 2 2 0 Ribosomal protein L14p/L23e DUF1295 PF06966.12 ETO20122.1 - 1.2e-14 54.4 0.1 3e-14 53.1 0.0 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) Steroid_dh PF02544.16 ETO20122.1 - 2.1e-05 24.6 0.2 4.8e-05 23.4 0.1 1.6 1 1 0 1 1 1 1 3-oxo-5-alpha-steroid 4-dehydrogenase ICMT PF04140.14 ETO20122.1 - 0.04 14.3 0.0 0.089 13.2 0.0 1.6 1 0 0 1 1 1 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO20122.1 - 0.19 12.1 2.3 0.17 12.3 0.6 1.9 2 1 0 2 2 2 0 Phospholipid methyltransferase NDK PF00334.19 ETO20123.1 - 9.8e-24 83.9 0.0 1.4e-11 44.5 0.0 2.8 2 1 0 2 2 2 2 Nucleoside diphosphate kinase MSG PF02349.15 ETO20123.1 - 0.0022 18.2 3.1 0.0022 18.2 3.1 2.3 2 1 0 2 2 2 1 Major surface glycoprotein zf-RING_13 PF17977.1 ETO20123.1 - 0.039 14.1 0.0 0.17 12.0 0.0 2.0 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain Ycf70 PF17382.2 ETO20123.1 - 0.21 12.0 4.1 0.89 10.0 4.1 2.0 1 0 0 1 1 1 0 Uncharacterized Ycf70-like Pox_H7 PF04787.12 ETO20124.1 - 0.012 16.1 2.3 0.012 16.1 2.3 2.1 2 0 0 2 2 2 0 Late protein H7 Swi5 PF07061.11 ETO20124.1 - 0.036 14.1 0.5 0.036 14.1 0.5 3.9 1 1 2 3 3 3 0 Swi5 Laminin_II PF06009.12 ETO20124.1 - 0.31 11.1 14.0 0.069 13.2 4.6 2.9 2 1 1 3 3 3 0 Laminin Domain II DUF1664 PF07889.12 ETO20124.1 - 0.45 10.6 13.8 0.75 9.9 4.0 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF489 PF04356.12 ETO20124.1 - 0.81 9.7 8.9 2.5 8.1 2.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF489) Occludin_ELL PF07303.13 ETO20124.1 - 0.92 10.3 26.4 1.2 9.9 7.4 3.3 1 1 1 3 3 3 0 Occludin homology domain Sec3_C_2 PF15278.6 ETO20124.1 - 1.6 9.2 7.8 0.27 11.6 0.4 3.1 3 2 1 4 4 4 0 Sec3 exocyst complex subunit NPV_P10 PF05531.12 ETO20124.1 - 5 7.7 12.2 12 6.4 3.7 3.4 2 2 0 2 2 2 0 Nucleopolyhedrovirus P10 protein PolyA_pol PF01743.20 ETO20125.1 - 2.8e-06 27.8 0.1 9.9e-05 22.8 0.0 2.7 1 1 1 2 2 2 1 Poly A polymerase head domain DUF3616 PF12275.8 ETO20125.1 - 0.033 13.6 0.0 0.055 12.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3616) Ribosomal_L1 PF00687.21 ETO20126.1 - 6.4e-26 91.4 0.0 1.6e-25 90.1 0.0 1.6 1 1 0 1 1 1 1 Ribosomal protein L1p/L10e family Amidase_6 PF12671.7 ETO20127.1 - 0.0065 16.6 0.0 0.011 15.8 0.0 1.3 1 0 0 1 1 1 1 Putative amidase domain Tom6 PF17112.5 ETO20127.1 - 0.079 12.5 0.7 0.15 11.6 0.0 1.8 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom6, fungal DAGK_acc PF00609.19 ETO20128.1 - 1.1e-29 103.8 0.0 2.3e-29 102.8 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ETO20128.1 - 1.9e-16 59.8 0.0 4.4e-16 58.6 0.0 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain Yippee-Mis18 PF03226.14 ETO20129.1 - 2.2e-12 47.1 4.8 2.2e-12 47.1 4.8 2.2 2 0 0 2 2 2 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly SelR PF01641.18 ETO20129.1 - 0.0013 18.8 3.1 0.0013 18.8 3.1 1.8 2 0 0 2 2 2 1 SelR domain Chorion_2 PF03964.15 ETO20129.1 - 0.074 13.9 2.5 0.083 13.7 1.1 1.8 2 0 0 2 2 2 0 Chorion family 2 Zn_ribbon_SprT PF17283.2 ETO20129.1 - 1.6 8.7 9.2 0.84 9.6 3.8 2.3 2 0 0 2 2 2 0 SprT-like zinc ribbon domain Ndc1_Nup PF09531.10 ETO20129.1 - 6.5 5.3 6.6 9 4.8 6.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PP2C PF00481.21 ETO20130.1 - 0.0036 17.0 5.6 0.071 12.7 0.1 2.4 2 1 0 2 2 2 2 Protein phosphatase 2C CDC45 PF02724.14 ETO20131.1 - 0.076 11.3 19.6 0.11 10.8 19.6 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ETO20131.1 - 0.088 11.4 33.0 0.11 11.1 33.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Ndc1_Nup PF09531.10 ETO20131.1 - 0.21 10.3 13.1 0.27 9.9 13.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LAP1C PF05609.12 ETO20131.1 - 0.59 9.2 15.2 0.76 8.8 15.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF908 PF06012.12 ETO20131.1 - 1.1 8.6 17.9 1.7 7.9 17.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Nop14 PF04147.12 ETO20131.1 - 1.1 7.3 19.9 1.3 7.1 19.9 1.2 1 0 0 1 1 1 0 Nop14-like family TAF4 PF05236.14 ETO20131.1 - 1.6 8.4 16.3 2.5 7.8 16.3 1.4 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family SOG2 PF10428.9 ETO20131.1 - 3.4 6.8 15.2 4.4 6.4 15.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein QWRF PF04484.12 ETO20131.1 - 3.5 7.3 15.3 5.9 6.5 15.3 1.4 1 0 0 1 1 1 0 QWRF family Spt5_N PF11942.8 ETO20131.1 - 3.5 8.7 15.0 11 7.1 15.0 1.9 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal LMBR1 PF04791.16 ETO20134.1 - 0.012 14.6 4.6 0.015 14.2 4.6 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 ETO20134.1 - 0.043 13.4 1.9 0.057 13.0 1.9 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 ETO20134.1 - 0.056 12.8 6.8 0.071 12.4 6.8 1.1 1 0 0 1 1 1 0 FAM76 protein Prominin PF05478.11 ETO20134.1 - 0.62 8.0 5.4 0.87 7.5 5.4 1.1 1 0 0 1 1 1 0 Prominin Baculo_PEP_C PF04513.12 ETO20134.1 - 0.93 9.5 4.3 2.4 8.2 3.1 2.1 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Noelin-1 PF12308.8 ETO20134.1 - 2.5 8.1 6.8 5.7 7.0 1.0 2.6 2 1 0 3 3 3 0 Neurogenesis glycoprotein DUF2205 PF10224.9 ETO20134.1 - 5.6 7.0 10.4 28 4.8 5.1 2.8 1 1 1 2 2 2 0 Short coiled-coil protein PARG_cat PF05028.14 ETO20135.1 - 7.4e-16 58.4 0.1 8.7e-16 58.1 0.1 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Cir_N PF10197.9 ETO20136.1 - 2.5e-07 30.7 12.7 2.5e-07 30.7 12.7 5.5 4 2 1 5 5 5 1 N-terminal domain of CBF1 interacting co-repressor CIR Kelch_6 PF13964.6 ETO20137.1 - 8e-07 29.1 8.1 0.012 15.9 0.2 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO20137.1 - 1.1e-06 28.3 5.4 0.00049 20.0 0.1 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO20137.1 - 0.0016 18.0 1.1 2.6 7.7 0.1 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO20137.1 - 0.0022 17.9 0.2 0.0022 17.9 0.2 3.4 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO20137.1 - 0.0092 16.0 14.8 0.015 15.3 1.1 4.9 6 0 0 6 6 6 2 Kelch motif DASH_Dad4 PF08650.10 ETO20140.1 - 0.022 14.7 0.5 5.7 7.0 0.0 2.6 3 0 0 3 3 3 0 DASH complex subunit Dad4 Kelch_6 PF13964.6 ETO20142.1 - 1.7e-05 24.9 0.1 0.01 16.1 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO20142.1 - 2.5e-05 24.1 0.6 0.0045 16.9 0.1 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO20142.1 - 0.00096 19.4 0.0 0.0054 17.0 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO20142.1 - 0.0017 18.3 2.4 4.7 7.3 0.2 5.3 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO20142.1 - 0.0024 17.4 0.2 0.33 10.6 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO20142.1 - 0.0068 16.4 0.0 0.025 14.6 0.0 2.0 1 0 0 1 1 1 1 Galactose oxidase, central domain Peptidase_C14 PF00656.22 ETO20143.1 - 5.4e-11 42.9 3.3 1.2e-10 41.8 3.3 1.6 1 1 0 1 1 1 1 Caspase domain ER PF01133.17 ETO20143.1 - 0.063 13.3 0.6 0.063 13.3 0.6 3.5 3 1 0 3 3 3 0 Enhancer of rudimentary NACHT PF05729.12 ETO20144.1 - 8.1e-15 55.1 0.0 1.3e-13 51.2 0.0 3.1 2 1 0 2 2 2 1 NACHT domain HEAT PF02985.22 ETO20144.1 - 2.1e-13 49.3 0.1 0.16 12.3 0.0 9.3 11 0 0 11 11 10 2 HEAT repeat HEAT_2 PF13646.6 ETO20144.1 - 1.7e-09 38.0 0.0 0.039 14.4 0.0 5.4 3 2 3 6 6 6 2 HEAT repeats Cnd1 PF12717.7 ETO20144.1 - 2.3e-08 34.3 29.2 0.006 16.6 1.7 6.1 1 1 3 4 4 4 3 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO20144.1 - 3.1e-06 27.5 0.1 1.9 9.0 0.0 6.2 5 1 1 6 6 6 1 HEAT-like repeat Ank_3 PF13606.6 ETO20144.1 - 0.0016 18.8 0.1 0.4 11.4 0.0 3.7 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO20144.1 - 0.0021 18.6 0.1 0.0086 16.6 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO20144.1 - 0.0046 17.5 0.1 0.071 13.7 0.0 3.2 4 0 0 4 4 1 1 Ankyrin repeats (3 copies) Erf4 PF10256.9 ETO20144.1 - 0.022 14.9 5.1 1.3 9.1 0.0 4.3 3 1 1 4 4 3 0 Golgin subfamily A member 7/ERF4 family AAA_22 PF13401.6 ETO20144.1 - 0.046 14.0 2.7 0.77 10.0 0.0 4.4 5 0 0 5 5 4 0 AAA domain Ank_5 PF13857.6 ETO20144.1 - 0.066 13.6 0.1 0.34 11.3 0.0 2.3 2 0 0 2 2 1 0 Ankyrin repeats (many copies) Vac14_Fab1_bd PF12755.7 ETO20144.1 - 0.078 13.6 16.4 11 6.7 0.1 6.9 4 3 2 7 7 7 0 Vacuolar 14 Fab1-binding region NLRC4_HD2 PF17776.1 ETO20144.1 - 0.079 13.5 0.0 0.079 13.5 0.0 5.3 7 0 0 7 7 6 0 NLRC4 helical domain HD2 Ank PF00023.30 ETO20144.1 - 0.095 13.2 0.0 0.47 11.0 0.0 2.3 1 0 0 1 1 1 0 Ankyrin repeat ABC_tran PF00005.27 ETO20144.1 - 0.12 12.9 0.1 4.8 7.7 0.0 3.4 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ETO20144.1 - 0.15 12.5 0.0 1.4 9.3 0.0 2.7 2 0 0 2 2 1 0 AAA ATPase domain TraC PF07820.12 ETO20144.1 - 0.17 12.2 0.3 33 4.9 0.0 3.6 2 1 1 3 3 3 0 TraC-like protein Glycoprot_B_PH1 PF17416.2 ETO20145.1 - 0.16 11.6 0.8 3.8 7.1 0.2 2.4 2 0 0 2 2 2 0 Herpesvirus Glycoprotein B PBP1_TM PF14812.6 ETO20147.1 - 0.0014 19.0 11.5 0.0022 18.3 11.5 1.3 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO20147.1 - 0.024 14.0 6.3 0.026 13.8 6.3 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETO20147.1 - 0.074 12.6 14.0 0.088 12.4 14.0 1.1 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 ETO20147.1 - 0.15 11.8 15.1 0.19 11.4 15.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 ETO20147.1 - 0.23 11.1 11.1 0.041 13.6 7.0 1.7 2 0 0 2 2 2 0 FAM176 family AAA_11 PF13086.6 ETO20147.1 - 0.24 11.2 5.1 0.3 10.8 5.1 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 ETO20147.1 - 1.7 7.3 7.8 2 7.1 7.8 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_Rpc4 PF05132.14 ETO20147.1 - 2 8.8 9.2 2 8.8 3.3 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 RRN3 PF05327.11 ETO20147.1 - 2.1 6.8 6.6 2.2 6.7 6.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RNA_polI_A34 PF08208.11 ETO20147.1 - 5.7 7.0 19.2 4.6 7.3 14.6 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Circo_capsid PF02443.15 ETO20148.1 - 0.44 10.1 6.1 0.2 11.2 3.1 1.8 2 0 0 2 2 2 0 Circovirus capsid protein Guanylate_cyc PF00211.20 ETO20149.1 - 5.2e-05 22.9 0.0 0.11 12.1 0.0 2.2 1 1 1 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF389 PF04087.14 ETO20150.1 - 0.045 13.8 0.5 0.068 13.2 0.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF389) DUF3397 PF11877.8 ETO20150.1 - 0.89 9.8 5.9 1.3 9.2 5.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3397) Aminotran_3 PF00202.21 ETO20152.1 - 6.7e-32 110.6 0.0 8.5e-32 110.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III ALS_ss_C PF10369.9 ETO20152.1 - 0.084 13.1 0.0 16 5.8 0.0 2.6 2 0 0 2 2 2 0 Small subunit of acetolactate synthase KAP_NTPase PF07693.14 ETO20153.1 - 2.9e-35 122.1 0.1 2.1e-34 119.2 0.1 2.0 1 1 0 1 1 1 1 KAP family P-loop domain AAA_22 PF13401.6 ETO20153.1 - 0.0009 19.5 0.0 0.86 9.9 0.0 2.6 2 0 0 2 2 2 2 AAA domain Elong_Iki1 PF10483.9 ETO20153.1 - 0.0094 15.5 0.0 0.015 14.9 0.0 1.2 1 0 0 1 1 1 1 Elongator subunit Iki1 IIGP PF05049.13 ETO20153.1 - 0.031 13.4 0.0 0.071 12.1 0.0 1.5 2 0 0 2 2 2 0 Interferon-inducible GTPase (IIGP) AAA_16 PF13191.6 ETO20153.1 - 0.048 14.0 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain CREPT PF16566.5 ETO20154.1 - 0.059 13.5 2.6 0.079 13.1 0.0 2.0 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour Ycf70 PF17382.2 ETO20154.1 - 0.13 12.7 0.1 0.13 12.7 0.1 2.6 2 1 0 2 2 2 0 Uncharacterized Ycf70-like Dynactin_p62 PF05502.13 ETO20154.1 - 0.61 8.8 3.8 2.7 6.6 0.0 2.1 2 0 0 2 2 2 0 Dynactin p62 family Sigma_reg_N PF13800.6 ETO20155.1 - 0.26 11.6 0.1 0.26 11.6 0.1 3.0 1 1 2 3 3 3 0 Sigma factor regulator N-terminal SH PF01445.17 ETO20155.1 - 1.5 8.9 5.0 0.79 9.7 1.9 2.0 2 0 0 2 2 2 0 Viral small hydrophobic protein RhoGEF PF00621.20 ETO20156.1 - 9.5e-30 104.2 8.2 3.8e-28 99.0 5.8 3.2 2 1 0 2 2 2 1 RhoGEF domain DUF3139 PF11337.8 ETO20156.1 - 0.56 10.9 6.3 0.079 13.6 1.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3139) WD40 PF00400.32 ETO20157.1 - 0.35 11.8 5.7 22 6.1 0.0 6.3 7 1 0 7 7 7 0 WD domain, G-beta repeat Glyco_tran_10_N PF17039.5 ETO20158.1 - 2.9e-09 37.4 0.1 1.3e-08 35.3 0.1 2.1 1 1 0 1 1 1 1 Fucosyltransferase, N-terminal Glyco_transf_10 PF00852.19 ETO20158.1 - 1.1e-05 25.3 0.0 3.5e-05 23.6 0.0 1.7 2 0 0 2 2 2 1 Glycosyltransferase family 10 (fucosyltransferase) C-term Lactococcin_972 PF09683.10 ETO20158.1 - 0.12 12.9 0.0 0.25 11.9 0.0 1.5 1 0 0 1 1 1 0 Bacteriocin (Lactococcin_972) Glyco_transf_10 PF00852.19 ETO20159.1 - 2.9e-29 102.1 2.9 3.3e-29 101.8 2.9 1.1 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term CSD PF00313.22 ETO20160.1 - 0.0019 18.0 0.0 0.048 13.5 0.0 3.0 3 0 0 3 3 3 1 'Cold-shock' DNA-binding domain ArsA_HSP20 PF17886.1 ETO20160.1 - 0.0068 16.0 0.0 0.018 14.6 0.0 1.7 1 0 0 1 1 1 1 HSP20-like domain found in ArsA DUF3119 PF11317.8 ETO20160.1 - 0.026 14.8 1.1 0.068 13.5 1.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) ENTH PF01417.20 ETO20162.1 - 0.00024 21.2 1.2 0.0027 17.7 1.2 2.2 1 1 0 1 1 1 1 ENTH domain XK-related PF09815.9 ETO20162.1 - 0.058 12.5 3.3 0.095 11.7 3.3 1.2 1 0 0 1 1 1 0 XK-related protein Herpes_UL92 PF03048.14 ETO20162.1 - 0.062 13.1 4.1 0.087 12.6 4.1 1.2 1 0 0 1 1 1 0 UL92 family Shisa PF13908.6 ETO20162.1 - 0.096 12.9 0.3 0.11 12.7 0.3 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF5436 PF17504.2 ETO20162.1 - 1.5 9.2 10.8 0.99 9.8 2.9 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5436) ATPase_2 PF01637.18 ETO20163.1 - 4.7e-06 26.7 0.1 1.1e-05 25.4 0.1 1.7 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO20163.1 - 5.2e-06 27.0 0.0 1.2e-05 25.7 0.0 1.7 1 1 0 1 1 1 1 AAA ATPase domain NACHT PF05729.12 ETO20163.1 - 6e-06 26.3 0.0 1.4e-05 25.1 0.0 1.7 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO20163.1 - 0.00085 19.6 0.1 0.0028 17.9 0.1 2.0 1 1 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO20163.1 - 0.051 13.5 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase HapK PF11639.8 ETO20163.1 - 0.086 13.3 0.1 0.23 12.0 0.1 1.6 1 0 0 1 1 1 0 REDY-like protein HapK NTPase_1 PF03266.15 ETO20163.1 - 0.11 12.5 0.1 0.28 11.1 0.1 1.7 1 1 0 1 1 1 0 NTPase MAPEG PF01124.18 ETO20164.1 - 8.7e-07 28.9 0.5 1.1e-06 28.6 0.5 1.2 1 0 0 1 1 1 1 MAPEG family DUF423 PF04241.15 ETO20164.1 - 0.011 15.9 0.5 0.029 14.6 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF423) DUF3040 PF11239.8 ETO20164.1 - 0.13 12.5 4.0 0.89 9.9 1.4 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3040) PUB PF09409.10 ETO20165.1 - 0.017 15.1 0.2 0.017 15.1 0.2 2.6 3 0 0 3 3 3 0 PUB domain DUF2193 PF09959.9 ETO20166.1 - 0.083 11.3 0.0 0.12 10.8 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2193) MFS_1_like PF12832.7 ETO20167.1 - 6.8e-22 77.9 7.2 9.5e-14 51.0 3.7 2.6 3 0 0 3 3 3 2 MFS_1 like family MFS_1 PF07690.16 ETO20167.1 - 5.1e-11 42.1 5.9 6e-08 32.0 7.7 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily ATG22 PF11700.8 ETO20167.1 - 2.8e-05 23.0 0.0 0.0005 18.8 0.1 2.2 1 1 1 2 2 2 1 Vacuole effluxer Atg22 like G0-G1_switch_2 PF15103.6 ETO20167.1 - 0.00038 20.8 0.1 0.0011 19.3 0.0 2.0 2 0 0 2 2 2 1 G0/G1 switch protein 2 LacY_symp PF01306.19 ETO20167.1 - 0.0029 16.4 0.0 0.0029 16.4 0.0 2.1 2 0 0 2 2 2 1 LacY proton/sugar symporter Sugar_tr PF00083.24 ETO20167.1 - 0.0037 16.2 4.9 1.3 7.8 3.3 2.2 1 1 0 2 2 2 2 Sugar (and other) transporter INSIG PF07281.12 ETO20167.1 - 0.094 12.4 0.0 12 5.5 0.0 2.6 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) GWT1 PF06423.12 ETO20167.1 - 0.15 12.2 0.5 0.6 10.2 0.2 2.1 1 1 1 2 2 2 0 GWT1 EphA2_TM PF14575.6 ETO20167.1 - 0.18 12.7 2.6 16 6.4 0.4 3.5 2 2 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain YABBY PF04690.13 ETO20167.1 - 0.27 11.8 2.0 0.33 11.5 0.1 1.9 2 0 0 2 2 2 0 YABBY protein SF-assemblin PF06705.11 ETO20168.1 - 4.7e-23 81.8 30.5 5.9e-23 81.5 30.5 1.1 1 0 0 1 1 1 1 SF-assemblin/beta giardin Filament PF00038.21 ETO20168.1 - 0.0014 18.3 33.1 0.06 12.9 15.6 3.1 1 1 2 3 3 3 2 Intermediate filament protein DUF1664 PF07889.12 ETO20168.1 - 0.0081 16.2 24.4 0.2 11.7 2.9 4.4 1 1 4 5 5 5 2 Protein of unknown function (DUF1664) Allexi_40kDa PF05549.11 ETO20168.1 - 0.011 15.3 3.6 0.011 15.3 3.6 2.8 1 1 2 3 3 3 0 Allexivirus 40kDa protein Baculo_PEP_C PF04513.12 ETO20168.1 - 0.11 12.6 10.7 0.59 10.2 0.3 3.2 1 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 ETO20168.1 - 0.12 9.8 30.8 0.08 10.4 8.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) FAM184 PF15665.5 ETO20168.1 - 0.42 10.4 33.6 0.43 10.3 23.9 2.4 1 1 2 3 3 3 0 Family with sequence similarity 184, A and B NPV_P10 PF05531.12 ETO20168.1 - 1.2 9.7 9.0 0.5 10.9 0.4 3.7 1 1 2 3 3 3 0 Nucleopolyhedrovirus P10 protein GPW_gp25 PF04965.14 ETO20168.1 - 1.4 8.7 7.0 0.43 10.4 0.8 3.0 3 1 0 4 4 4 0 Gene 25-like lysozyme ApoLp-III PF07464.11 ETO20168.1 - 1.7 8.8 25.2 0.35 10.9 10.4 2.8 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Spot_14 PF07084.12 ETO20168.1 - 2.5 8.2 12.9 0.13 12.4 2.1 2.6 2 2 1 3 3 3 0 Thyroid hormone-inducible hepatic protein Spot 14 Goodbye PF17109.5 ETO20168.1 - 3.6 8.1 13.8 1.9 8.9 0.3 3.9 2 1 1 4 4 4 0 fungal STAND N-terminal Goodbye domain Phasin PF05597.11 ETO20168.1 - 3.6 7.6 21.0 0.041 13.9 5.0 2.8 2 1 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) GP41 PF00517.17 ETO20168.1 - 3.7 7.4 12.4 1 9.2 0.5 3.4 1 1 1 3 3 3 0 Retroviral envelope protein ArfGap PF01412.18 ETO20168.1 - 6.1 6.9 8.9 0.18 11.9 1.4 2.2 2 1 0 2 2 2 0 Putative GTPase activating protein for Arf DUF4239 PF14023.6 ETO20168.1 - 7.3 6.3 9.1 3 7.5 4.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4239) DUF4512 PF14975.6 ETO20169.1 - 8.4 7.3 5.9 48 4.8 5.9 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4512) RPEL PF02755.15 ETO20171.1 - 2.5e-05 23.8 0.9 5.9e-05 22.6 0.9 1.7 1 0 0 1 1 1 1 RPEL repeat KH_7 PF17214.3 ETO20171.1 - 0.075 13.0 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 KH domain Pox_G5 PF04599.12 ETO20172.1 - 0.0062 15.6 0.9 0.011 14.7 0.9 1.3 1 0 0 1 1 1 1 Poxvirus G5 protein KOG2701 PF09762.9 ETO20172.1 - 0.026 14.8 2.8 0.027 14.7 0.3 2.2 2 1 0 2 2 2 0 Coiled-coil domain-containing protein (DUF2037) DUF3037 PF11236.8 ETO20172.1 - 0.086 13.3 2.0 5.3 7.5 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) RRM_1 PF00076.22 ETO20174.1 - 6.8e-15 54.6 0.1 1.1e-14 53.9 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO20174.1 - 0.00049 19.7 0.0 0.00088 18.9 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sporozoite_P67 PF05642.11 ETO20175.1 - 0.0014 16.8 21.1 0.0014 16.8 21.1 4.5 1 1 4 5 5 5 1 Sporozoite P67 surface antigen Keratin_2_head PF16208.5 ETO20175.1 - 0.048 13.8 20.3 0.12 12.5 20.3 1.6 1 0 0 1 1 1 0 Keratin type II head Ras PF00071.22 ETO20176.1 - 5.3e-07 29.4 0.1 9.6e-07 28.5 0.1 1.5 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 ETO20176.1 - 0.015 14.9 0.9 0.016 14.8 0.5 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO20176.1 - 0.064 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 RsgA GTPase Pex14_N PF04695.13 ETO20178.1 - 0.0016 19.1 0.2 0.0027 18.4 0.2 1.3 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.25 ETO20179.1 - 1e-44 152.9 0.0 4e-42 144.4 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20179.1 - 4.6e-16 58.9 7.3 1.4e-11 44.2 0.0 2.9 3 1 1 4 4 4 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO20179.1 - 1.4e-05 24.1 0.0 1.4e-05 24.1 0.0 2.1 2 1 0 2 2 2 1 Fungal protein kinase APH PF01636.23 ETO20179.1 - 0.0006 19.8 0.0 0.00081 19.4 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO20179.1 - 0.0013 18.2 0.0 0.0024 17.2 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO20179.1 - 0.013 15.1 0.0 0.035 13.6 0.0 1.7 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Seadorna_VP7 PF07387.11 ETO20179.1 - 0.055 12.5 0.0 0.1 11.6 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 DUF3844 PF12955.7 ETO20179.1 - 0.077 13.1 2.7 0.22 11.7 2.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3844) MatP PF06303.12 ETO20179.1 - 0.094 13.3 2.1 0.6 10.7 2.3 2.2 2 0 0 2 2 2 0 MatP N-terminal domain SurA_N PF09312.11 ETO20180.1 - 0.0039 17.2 0.3 0.01 15.9 0.3 1.7 1 0 0 1 1 1 1 SurA N-terminal domain Suppressor_APC PF11414.8 ETO20180.1 - 0.034 14.2 0.3 0.15 12.2 0.3 2.0 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein Pam16 PF03656.13 ETO20181.1 - 3.1e-17 62.8 3.2 4.2e-17 62.3 3.2 1.2 1 0 0 1 1 1 1 Pam16 Nup54 PF13874.6 ETO20181.1 - 0.034 14.2 4.6 0.045 13.9 4.6 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 zf-C3HC4_3 PF13920.6 ETO20182.1 - 1.2e-06 28.3 8.1 1.2e-06 28.3 8.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO20182.1 - 2.4e-06 27.7 10.5 2.4e-06 27.7 10.5 2.4 2 1 0 2 2 2 1 Ring finger domain zf-TRAF PF02176.18 ETO20182.1 - 3.7e-06 27.5 2.6 3.7e-06 27.5 2.6 2.4 1 1 1 2 2 2 1 TRAF-type zinc finger zf-C3HC4 PF00097.25 ETO20182.1 - 9.4e-05 22.2 12.8 9.4e-05 22.2 12.8 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 ETO20182.1 - 0.00034 20.7 10.5 0.12 12.5 8.4 2.9 1 1 1 2 2 2 2 Protein of unknown function (DUF1644) zf-C3HC4_2 PF13923.6 ETO20182.1 - 0.0083 16.0 10.9 0.0083 16.0 10.9 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) GAGA PF09237.11 ETO20182.1 - 0.17 11.7 8.6 0.34 10.8 1.0 3.2 2 1 1 3 3 3 0 GAGA factor zf-RING_6 PF14835.6 ETO20182.1 - 0.23 11.4 5.1 0.5 10.3 5.1 1.6 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-C3HC4_4 PF15227.6 ETO20182.1 - 2.9 8.1 14.6 2.8 8.2 11.9 2.4 2 1 0 2 2 2 0 zinc finger of C3HC4-type, RING EF-hand_8 PF13833.6 ETO20183.1 - 0.02 14.7 0.9 1.1 9.1 0.2 3.1 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_1 PF00036.32 ETO20183.1 - 0.068 12.8 0.0 0.79 9.4 0.1 2.5 2 0 0 2 2 2 0 EF hand m04gp34like PF12216.8 ETO20184.1 - 0.094 12.3 3.5 0.097 12.2 3.5 1.1 1 0 0 1 1 1 0 Immune evasion protein Exo_endo_phos PF03372.23 ETO20185.1 - 0.089 12.3 0.0 0.17 11.4 0.0 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Pribosyltran_N PF13793.6 ETO20186.1 - 4.7e-36 123.3 0.0 4.5e-28 97.5 0.0 2.3 1 1 1 2 2 2 2 N-terminal domain of ribose phosphate pyrophosphokinase LolA_2 PF16584.5 ETO20187.1 - 0.066 13.1 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 Outer membrane lipoprotein carrier protein LolA Glutaredoxin PF00462.24 ETO20189.1 - 4.8e-17 61.9 0.0 1e-16 60.9 0.0 1.6 1 0 0 1 1 1 1 Glutaredoxin DUF2207 PF09972.9 ETO20192.1 - 0.013 14.3 1.3 0.016 14.0 1.3 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) LapA_dom PF06305.11 ETO20192.1 - 0.051 13.4 3.9 3.4 7.5 0.2 2.2 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain T4_Rnl2_C PF18043.1 ETO20192.1 - 0.085 13.0 0.0 0.14 12.3 0.0 1.3 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal DUF3671 PF12420.8 ETO20192.1 - 2.6 8.1 7.3 2.5 8.2 5.6 1.8 1 1 1 2 2 2 0 Protein of unknown function TatC PF00902.18 ETO20193.1 - 0.086 12.7 1.5 0.13 12.0 1.5 1.2 1 0 0 1 1 1 0 Sec-independent protein translocase protein (TatC) RNA_pol_Rbc25 PF08292.12 ETO20193.1 - 0.64 10.3 2.9 1.3 9.3 0.0 2.2 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 Pkinase_Tyr PF07714.17 ETO20196.1 - 1e-43 149.5 0.4 4.9e-30 104.7 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO20196.1 - 5.3e-36 124.3 0.5 1.3e-27 96.8 0.1 2.5 2 1 0 2 2 2 2 Protein kinase domain Dexa_ind PF15198.6 ETO20196.1 - 0.17 12.0 1.1 0.36 11.0 1.1 1.5 1 0 0 1 1 1 0 Dexamethasone-induced 14-3-3 PF00244.20 ETO20197.1 - 3.3e-09 36.6 1.7 3e-08 33.5 0.0 2.2 2 1 0 2 2 2 1 14-3-3 protein TT_ORF2 PF02957.15 ETO20198.1 - 0.087 13.8 1.2 0.23 12.4 1.2 1.7 1 0 0 1 1 1 0 TT viral ORF2 Kinesin PF00225.23 ETO20199.1 - 1.6e-61 208.1 0.9 2.2e-60 204.4 0.9 2.2 1 1 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO20199.1 - 2.6e-08 34.0 0.0 6.1e-08 32.7 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding Microtub_bd PF16796.5 ETO20200.1 - 3.6e-24 85.4 0.3 3.6e-24 85.4 0.3 3.0 2 1 1 3 3 3 1 Microtubule binding ADIP PF11559.8 ETO20200.1 - 0.0093 16.1 17.1 0.0093 16.1 17.1 4.6 2 1 3 5 5 5 1 Afadin- and alpha -actinin-Binding DUF4279 PF14106.6 ETO20200.1 - 1.2 9.4 9.7 1.3 9.2 0.3 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4279) APG6_N PF17675.1 ETO20200.1 - 5.5 7.5 49.3 8.8 6.9 12.7 4.3 2 1 1 4 4 4 0 Apg6 coiled-coil region E1-E2_ATPase PF00122.20 ETO20202.1 - 3.9e-37 127.5 0.0 8.6e-37 126.4 0.0 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Cation_ATPase_C PF00689.21 ETO20202.1 - 4.4e-30 104.7 7.0 2.7e-17 63.0 0.1 3.0 3 0 0 3 3 3 2 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ETO20202.1 - 4.1e-14 52.4 0.3 8.9e-14 51.3 0.3 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO20202.1 - 1.6e-09 38.3 1.8 4.2e-06 27.2 0.0 3.4 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase ubiquitin PF00240.23 ETO20202.1 - 0.00013 21.7 0.0 0.00032 20.4 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Cation_ATPase_N PF00690.26 ETO20202.1 - 0.00018 21.1 0.0 0.00051 19.7 0.0 1.8 1 0 0 1 1 1 1 Cation transporter/ATPase, N-terminus Hydrolase_3 PF08282.12 ETO20202.1 - 0.00096 19.0 1.5 0.00096 19.0 1.5 2.4 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase PABP PF00658.18 ETO20203.1 - 3.3e-07 30.4 0.0 5.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain TSP9 PF11493.8 ETO20203.1 - 0.11 13.2 0.2 0.11 13.2 0.2 1.8 2 0 0 2 2 2 0 Thylakoid soluble phosphoprotein TSP9 SRC-1 PF08832.10 ETO20203.1 - 6.9 7.8 9.5 0.31 12.1 0.7 2.5 1 1 1 2 2 2 0 Steroid receptor coactivator RRM_1 PF00076.22 ETO20204.1 - 1.4e-14 53.6 0.4 2.5e-06 27.2 0.1 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO20204.1 - 0.034 14.1 0.0 0.67 10.0 0.0 2.5 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Cep57_CLD_2 PF14197.6 ETO20205.1 - 0.021 14.9 2.5 0.04 14.0 2.5 1.5 1 1 0 1 1 1 0 Centrosome localisation domain of PPC89 YojJ PF10372.9 ETO20205.1 - 0.022 14.8 0.3 0.05 13.7 0.2 1.7 1 1 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Ax_dynein_light PF10211.9 ETO20205.1 - 0.03 14.3 1.8 0.038 13.9 1.8 1.1 1 0 0 1 1 1 0 Axonemal dynein light chain DUF4201 PF13870.6 ETO20205.1 - 0.043 13.5 3.9 0.056 13.2 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) SKA2 PF16740.5 ETO20205.1 - 0.07 12.9 1.6 0.091 12.5 1.6 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 Allexi_40kDa PF05549.11 ETO20205.1 - 0.09 12.3 0.6 0.11 11.9 0.6 1.1 1 0 0 1 1 1 0 Allexivirus 40kDa protein Noelin-1 PF12308.8 ETO20205.1 - 0.12 12.4 0.3 0.17 11.9 0.3 1.4 1 0 0 1 1 1 0 Neurogenesis glycoprotein Med4 PF10018.9 ETO20205.1 - 0.17 11.6 4.0 0.23 11.1 3.8 1.3 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 GTP-bdg_M PF16360.5 ETO20205.1 - 0.19 12.3 3.9 0.23 12.1 1.7 1.9 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region Csm1_N PF18504.1 ETO20205.1 - 0.2 12.0 3.2 2.3 8.6 2.4 2.1 1 1 1 2 2 2 0 Csm1 N-terminal domain Sirohm_synth_C PF14823.6 ETO20205.1 - 0.22 11.2 0.3 22 4.8 0.0 2.3 1 1 1 2 2 2 0 Sirohaem biosynthesis protein C-terminal ABC_tran_CTD PF16326.5 ETO20205.1 - 0.75 10.1 4.7 6.3 7.1 0.8 2.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain Kelch_4 PF13418.6 ETO20206.1 - 5.6e-05 23.1 0.0 0.001 19.0 0.0 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO20206.1 - 8.1e-05 22.8 0.0 0.019 15.2 0.0 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO20206.1 - 0.00082 18.9 0.0 0.015 14.9 0.0 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO20206.1 - 0.0022 18.2 0.3 0.17 12.2 0.0 2.9 2 1 1 3 3 3 1 Kelch motif NACHT PF05729.12 ETO20213.1 - 2.5e-08 34.0 0.0 5.9e-08 32.8 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO20213.1 - 0.00057 20.2 0.2 0.0086 16.3 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO20213.1 - 0.0011 19.6 1.2 0.024 15.2 0.0 3.3 2 1 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ETO20213.1 - 0.0015 18.8 0.1 0.0093 16.3 0.0 2.5 1 1 0 1 1 1 1 RNA helicase RsgA_GTPase PF03193.16 ETO20213.1 - 0.0068 16.3 0.2 0.022 14.7 0.2 1.9 1 0 0 1 1 1 1 RsgA GTPase ATP_bind_2 PF03668.15 ETO20213.1 - 0.0092 15.3 0.0 0.02 14.2 0.0 1.6 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_16 PF13191.6 ETO20213.1 - 0.015 15.7 0.1 0.38 11.1 0.1 2.8 1 1 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ETO20213.1 - 0.023 14.7 0.0 0.08 12.9 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ETO20213.1 - 0.03 14.0 0.1 0.074 12.8 0.1 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 ETO20213.1 - 0.043 14.2 0.0 0.12 12.8 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ETO20213.1 - 0.046 13.1 0.7 2.3 7.5 0.0 3.1 3 0 0 3 3 3 0 KaiC ORC_WH_C PF18137.1 ETO20213.1 - 0.09 12.9 3.9 0.33 11.0 3.9 1.9 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal RSB_motif PF16294.5 ETO20213.1 - 0.45 10.8 18.4 0.52 10.6 0.1 3.5 3 0 0 3 3 3 0 RNSP1-SAP18 binding (RSB) motif MRNIP PF15749.5 ETO20213.1 - 0.51 11.1 18.8 0.059 14.1 7.2 3.7 3 0 0 3 3 3 0 MRN-interacting protein Cas_Csy4 PF09618.10 ETO20213.1 - 1.4 9.0 10.1 0.5 10.5 4.4 2.8 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csy4) Secretin_N_2 PF07655.13 ETO20213.1 - 4.5 7.9 10.2 1.2 9.8 3.2 3.2 3 0 0 3 3 3 0 Secretin N-terminal domain EIIBC-GUT_N PF03612.14 ETO20213.1 - 6 6.6 7.3 5.4 6.7 4.9 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus FAM176 PF14851.6 ETO20213.1 - 7.2 6.3 8.9 7.5 6.2 4.6 2.6 2 0 0 2 2 2 0 FAM176 family Glu-tRNAGln PF02686.15 ETO20214.1 - 0.1 12.9 2.3 0.2 12.0 0.2 2.5 2 1 0 2 2 2 0 Glu-tRNAGln amidotransferase C subunit TMCO5 PF14992.6 ETO20214.1 - 0.21 11.1 36.7 0.01 15.4 23.2 2.2 1 1 1 2 2 2 0 TMCO5 family KxDL PF10241.9 ETO20214.1 - 7.1 7.0 21.4 0.037 14.3 7.8 3.4 2 2 1 4 4 4 0 Uncharacterized conserved protein Cpn60_TCP1 PF00118.24 ETO20215.1 - 5.1e-21 74.9 0.0 5.7e-21 74.7 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family ATPase_2 PF01637.18 ETO20217.1 - 0.032 14.1 0.0 0.032 14.1 0.0 2.9 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea EF-hand_1 PF00036.32 ETO20218.1 - 1.4e-17 61.9 7.6 0.0014 18.1 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO20218.1 - 2.8e-14 51.7 7.2 0.0038 17.0 0.0 4.8 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO20218.1 - 1.1e-13 49.9 9.2 0.00023 20.5 0.0 4.6 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO20218.1 - 2.1e-13 50.5 10.0 5.4e-06 26.8 1.3 4.1 2 2 0 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ETO20218.1 - 4e-07 29.8 8.5 0.014 15.2 0.1 4.6 4 1 1 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO20218.1 - 5.9e-05 23.4 7.7 0.019 15.3 0.6 3.2 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Dockerin_1 PF00404.18 ETO20218.1 - 0.074 13.3 0.3 4.3 7.6 0.0 3.0 3 1 0 3 3 3 0 Dockerin type I domain Pex14_N PF04695.13 ETO20220.1 - 0.038 14.6 8.5 0.06 14.0 7.7 1.7 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RabGAP-TBC PF00566.18 ETO20221.1 - 2.4e-35 122.2 13.8 3.6e-29 102.0 7.9 2.7 2 1 0 2 2 2 2 Rab-GTPase-TBC domain Chromo PF00385.24 ETO20222.1 - 3.2e-14 52.6 3.9 8.5e-07 28.8 0.7 3.0 2 1 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain Nop14 PF04147.12 ETO20222.1 - 0.0062 14.8 25.1 0.0081 14.4 25.1 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 ETO20222.1 - 0.02 13.2 19.6 0.025 12.9 19.6 1.2 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO20222.1 - 0.036 13.4 27.9 0.054 12.8 27.9 1.2 1 0 0 1 1 1 0 BUD22 DNA_pol_phi PF04931.13 ETO20222.1 - 0.057 11.5 34.7 0.099 10.7 34.7 1.3 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO20222.1 - 8.1 5.7 34.3 17 4.6 34.3 1.5 1 0 0 1 1 1 0 NOA36 protein MaoC_dehydratas PF01575.19 ETO20225.1 - 2.2e-14 53.1 0.0 3.1e-14 52.6 0.0 1.3 1 0 0 1 1 1 1 MaoC like domain Peptidase_C48 PF02902.19 ETO20226.1 - 1.5e-28 100.1 4.8 2.1e-28 99.7 4.8 1.2 1 0 0 1 1 1 1 Ulp1 protease family, C-terminal catalytic domain Lysis_col PF02402.16 ETO20226.1 - 0.12 12.1 0.1 0.21 11.3 0.1 1.4 1 0 0 1 1 1 0 Lysis protein MetW PF07021.12 ETO20227.1 - 0.058 13.0 0.3 0.43 10.2 0.2 2.1 2 0 0 2 2 2 0 Methionine biosynthesis protein MetW DDHD PF02862.17 ETO20229.1 - 0.022 14.9 1.2 0.032 14.4 1.2 1.4 1 0 0 1 1 1 0 DDHD domain RMP PF14996.6 ETO20229.1 - 0.038 14.2 0.7 0.038 14.2 0.7 1.7 2 0 0 2 2 1 0 Retinal Maintenance Vfa1 PF08432.10 ETO20229.1 - 0.17 12.2 17.9 0.28 11.5 17.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NARP1 PF12569.8 ETO20229.1 - 0.37 9.6 15.2 0.49 9.2 15.2 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RPN2_C PF18004.1 ETO20229.1 - 0.44 10.5 18.9 0.86 9.5 18.9 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Cytomega_UL84 PF06284.11 ETO20229.1 - 0.48 8.8 5.9 0.7 8.3 5.9 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein HsdM_N PF12161.8 ETO20229.1 - 0.65 10.6 7.4 1.5 9.5 6.8 1.9 1 1 0 1 1 1 0 HsdM N-terminal domain PRIMA1 PF16101.5 ETO20229.1 - 0.66 10.0 5.2 1.5 8.9 5.2 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 FancD2 PF14631.6 ETO20229.1 - 0.72 7.2 5.6 0.89 6.9 5.6 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease RNA_polI_A34 PF08208.11 ETO20229.1 - 1.1 9.3 24.2 2.4 8.2 24.2 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4603 PF15376.6 ETO20229.1 - 1.6 6.1 12.2 2 5.7 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4603) Zip PF02535.22 ETO20229.1 - 2.5 7.3 4.7 2.9 7.0 4.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PA26 PF04636.13 ETO20229.1 - 2.5 6.9 6.6 3.3 6.5 6.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) VIR_N PF15912.5 ETO20229.1 - 2.6 7.6 21.7 4.6 6.8 12.8 2.2 2 0 0 2 2 2 0 Virilizer, N-terminal DUF4770 PF15994.5 ETO20229.1 - 3.7 7.8 14.6 0.67 10.2 10.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4770) Connexin PF00029.19 ETO20229.1 - 4.6 6.9 8.6 6.8 6.4 8.6 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO20229.1 - 4.6 5.9 7.6 6 5.5 7.6 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO20229.1 - 5.9 5.1 10.4 7.5 4.7 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Hydrolase_3 PF08282.12 ETO20229.1 - 6.6 6.4 10.5 15 5.3 10.5 1.7 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase O-antigen_lig PF13425.6 ETO20229.1 - 6.7 5.4 5.5 10 4.8 5.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein U1snRNP70_N PF12220.8 ETO20229.1 - 8 7.2 18.9 1.8 9.3 15.1 1.9 2 0 0 2 2 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal WD40 PF00400.32 ETO20230.1 - 2.8e-59 195.7 25.7 2.4e-09 37.7 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20230.1 - 7.2e-24 83.9 3.2 3.7e-05 23.9 0.1 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20230.1 - 2.2e-17 63.0 0.5 0.011 14.7 0.0 6.7 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome_A_N PF10584.9 ETO20230.1 - 8.2e-06 25.4 4.8 1.2 8.9 0.2 5.9 6 0 0 6 6 6 1 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETO20230.1 - 3e-05 22.7 0.3 0.43 9.1 0.0 3.8 1 1 2 4 4 4 2 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO20230.1 - 3.6e-05 23.0 2.3 0.13 11.3 0.2 3.8 1 1 3 4 4 4 2 Coatomer WD associated region WD40_like PF17005.5 ETO20230.1 - 4.1e-05 23.1 0.2 0.64 9.3 0.0 3.1 2 1 2 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO20230.1 - 0.00034 20.5 9.8 2.1 8.4 0.1 5.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO20230.1 - 0.003 17.7 4.0 9.2 6.4 0.0 4.4 2 1 3 5 5 5 1 Family of unknown function (DUF5570) HARP PF07443.13 ETO20230.1 - 0.0038 16.8 0.1 0.84 9.3 0.0 3.1 2 0 0 2 2 2 1 HepA-related protein (HARP) RGS PF00615.19 ETO20231.1 - 7.2e-09 36.0 2.2 0.00017 21.9 0.2 2.4 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF773 PF05600.12 ETO20231.1 - 0.016 14.0 2.6 0.023 13.5 2.6 1.2 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Pkinase PF00069.25 ETO20233.1 - 3.1e-57 193.9 0.1 3.8e-57 193.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20233.1 - 6.6e-28 97.7 0.1 3.8e-27 95.2 0.1 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kelch_4 PF13418.6 ETO20233.1 - 7.5e-05 22.7 0.1 0.00016 21.6 0.1 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kinase-like PF14531.6 ETO20233.1 - 0.0011 18.3 0.0 0.0019 17.5 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO20233.1 - 0.015 14.1 0.0 0.024 13.4 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ETO20233.1 - 0.17 11.4 1.8 5 6.6 0.0 2.8 2 1 1 3 3 3 0 PhoP regulatory network protein YrbL DUF5061 PF16587.5 ETO20234.1 - 0.021 14.9 0.6 0.038 14.0 0.6 1.5 1 0 0 1 1 1 0 17 kDa common-antigen outer membrane protein PX PF00787.24 ETO20235.1 - 2e-14 53.5 4.6 8.2e-13 48.3 2.3 2.5 2 0 0 2 2 2 2 PX domain Methyltransf_12 PF08242.12 ETO20235.1 - 4.1 8.2 5.9 1.6 9.6 1.2 2.5 2 0 0 2 2 2 0 Methyltransferase domain ABC_tran PF00005.27 ETO20236.1 - 1.5e-34 119.4 0.1 1.1e-21 77.8 0.0 2.7 3 0 0 3 3 3 2 ABC transporter ABC_tran_Xtn PF12848.7 ETO20236.1 - 7e-15 54.8 3.6 7e-15 54.8 3.6 1.8 2 0 0 2 2 1 1 ABC transporter AAA_21 PF13304.6 ETO20236.1 - 3e-12 47.0 0.5 0.0013 18.7 0.1 3.2 3 0 0 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO20236.1 - 6.4e-09 35.6 0.1 0.0052 16.3 0.0 3.2 2 1 1 3 3 3 2 RecF/RecN/SMC N terminal domain Fez1 PF06818.15 ETO20236.1 - 0.00013 22.5 1.6 0.00046 20.7 1.6 1.9 1 1 0 1 1 1 1 Fez1 RsgA_GTPase PF03193.16 ETO20236.1 - 0.0018 18.2 0.2 0.059 13.3 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase NACHT PF05729.12 ETO20236.1 - 0.0066 16.4 0.0 0.016 15.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain MeaB PF03308.16 ETO20236.1 - 0.0088 15.1 0.1 0.024 13.6 0.0 1.7 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_29 PF13555.6 ETO20236.1 - 0.019 14.7 0.1 0.054 13.2 0.0 1.7 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_15 PF13175.6 ETO20236.1 - 0.019 14.7 1.2 0.83 9.3 0.0 2.7 3 0 0 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 ETO20236.1 - 0.023 14.9 0.0 0.082 13.1 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETO20236.1 - 0.028 14.9 3.7 7.9 6.9 0.0 3.1 3 0 0 3 3 3 0 AAA domain AAA_16 PF13191.6 ETO20236.1 - 0.044 14.2 0.0 0.14 12.6 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain SbcCD_C PF13558.6 ETO20236.1 - 0.054 13.7 2.3 2.1 8.6 0.3 3.5 2 2 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RNA_helicase PF00910.22 ETO20236.1 - 0.1 13.0 0.2 0.84 10.1 0.0 2.7 3 0 0 3 3 3 0 RNA helicase MMR_HSR1 PF01926.23 ETO20236.1 - 0.12 12.4 0.0 0.45 10.6 0.0 2.0 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF4446 PF14584.6 ETO20236.1 - 0.62 10.0 6.1 8 6.4 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF948 PF06103.11 ETO20236.1 - 1 9.7 4.4 1.4 9.2 0.4 2.8 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Arm PF00514.23 ETO20237.1 - 4.8e-18 64.5 8.7 2.5e-05 24.1 0.0 7.6 9 0 0 9 9 9 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO20237.1 - 6.4e-08 32.9 0.9 0.0045 17.5 0.0 5.1 2 2 3 5 5 5 2 HEAT-like repeat HEAT_2 PF13646.6 ETO20237.1 - 0.00072 19.9 0.0 2.3 8.7 0.0 3.2 2 1 1 3 3 3 3 HEAT repeats RICTOR_V PF14668.6 ETO20237.1 - 0.00079 19.6 1.1 1.2 9.4 0.1 4.2 3 1 1 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 VanZ PF04892.12 ETO20237.1 - 0.0052 17.4 0.7 0.015 16.0 0.7 1.8 1 0 0 1 1 1 1 VanZ like family DUF2523 PF10734.9 ETO20237.1 - 0.16 12.5 0.0 0.66 10.6 0.0 2.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2523) DUF4474 PF14751.6 ETO20239.1 - 0.019 14.4 0.3 0.05 13.0 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4474) Rxt3 PF08642.10 ETO20239.1 - 0.075 13.8 0.2 0.16 12.7 0.2 1.5 1 0 0 1 1 1 0 Histone deacetylation protein Rxt3 BUD22 PF09073.10 ETO20241.1 - 0.65 9.3 41.0 0.73 9.1 41.0 1.0 1 0 0 1 1 1 0 BUD22 WWE PF02825.20 ETO20242.1 - 0.0038 17.8 0.7 0.0038 17.8 0.7 2.6 3 1 0 3 3 3 1 WWE domain Vfa1 PF08432.10 ETO20242.1 - 0.066 13.5 17.3 0.085 13.2 17.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Rgp1 PF08737.10 ETO20242.1 - 0.94 8.6 6.1 1.1 8.4 6.1 1.1 1 0 0 1 1 1 0 Rgp1 Sec62 PF03839.16 ETO20242.1 - 2.2 7.7 15.5 3.3 7.2 15.5 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 NPR3 PF03666.13 ETO20242.1 - 4.1 6.1 14.4 5.2 5.7 14.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SICA_C PF12879.7 ETO20243.1 - 0.068 13.2 0.3 0.12 12.4 0.0 1.6 2 0 0 2 2 2 0 SICA C-terminal inner membrane domain TALPID3 PF15324.6 ETO20244.1 - 0.25 9.0 9.5 0.01 13.6 4.0 1.4 2 0 0 2 2 2 0 Hedgehog signalling target XRN_M PF17846.1 ETO20244.1 - 0.26 10.2 4.6 0.41 9.5 0.0 2.0 2 0 0 2 2 2 0 Xrn1 helical domain DUF1476 PF07345.11 ETO20244.1 - 0.39 11.1 3.9 1.1 9.6 0.8 2.8 2 1 1 3 3 3 0 ATPase inhibitor subunit zeta SBDS_C PF09377.10 ETO20244.1 - 2.8 8.0 6.9 96 3.0 6.9 3.0 1 1 0 1 1 1 0 SBDS protein C-terminal domain FAM176 PF14851.6 ETO20245.1 - 0.049 13.3 1.2 0.062 13.0 1.2 1.2 1 0 0 1 1 1 0 FAM176 family Hid1 PF12722.7 ETO20246.1 - 1.2 7.2 15.2 1.5 6.9 15.2 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Neur_chan_memb PF02932.16 ETO20246.1 - 9.1 6.3 15.2 1.8 8.6 11.3 1.6 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SNARE PF05739.19 ETO20248.1 - 1.1e-08 34.9 0.7 1.1e-08 34.9 0.7 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ETO20248.1 - 3.6e-05 23.5 11.3 0.0028 17.4 0.6 2.9 2 1 1 3 3 3 2 Syntaxin DUF1877 PF08974.10 ETO20248.1 - 0.0006 19.9 0.1 0.00095 19.3 0.1 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1877) COPI_C PF06957.11 ETO20248.1 - 0.026 13.3 0.8 0.033 13.0 0.8 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus AI-2E_transport PF01594.16 ETO20248.1 - 0.13 11.4 1.0 0.18 10.9 0.3 1.5 1 1 1 2 2 2 0 AI-2E family transporter Complex1_LYR_2 PF13233.6 ETO20248.1 - 0.22 12.3 3.5 0.59 10.9 3.5 1.9 1 1 0 1 1 1 0 Complex1_LYR-like CHASE3 PF05227.13 ETO20248.1 - 0.23 11.4 3.3 0.18 11.7 1.1 1.9 2 2 0 2 2 2 0 CHASE3 domain DivIC PF04977.15 ETO20248.1 - 0.34 10.7 4.1 12 5.7 0.0 3.3 1 1 2 3 3 3 0 Septum formation initiator Spectrin PF00435.21 ETO20248.1 - 1.9 9.0 8.7 1.4 9.4 0.3 3.0 2 1 1 3 3 3 0 Spectrin repeat Suf PF05843.14 ETO20249.1 - 2.3e-19 70.5 0.2 2.3e-19 70.5 0.2 2.5 3 0 0 3 3 3 2 Suppressor of forked protein (Suf) NRDE-2 PF08424.10 ETO20250.1 - 0.079 12.1 0.2 0.17 10.9 0.2 1.6 1 1 0 1 1 1 0 NRDE-2, necessary for RNA interference ATP-synt_E_2 PF08112.11 ETO20250.1 - 0.12 12.7 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 ATP synthase epsilon subunit Med15 PF09606.10 ETO20252.1 - 0.0041 15.9 37.3 0.0048 15.7 37.3 1.0 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Utp14 PF04615.13 ETO20253.1 - 5e-05 22.1 38.0 8.5e-05 21.4 38.0 1.3 1 0 0 1 1 1 1 Utp14 protein Ndc1_Nup PF09531.10 ETO20253.1 - 2 7.0 16.7 0.24 10.0 9.4 2.4 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup PI3K_C2 PF00792.24 ETO20254.1 - 1.1e-13 51.3 0.0 1.1e-13 51.3 0.0 2.2 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ETO20254.1 - 1.4e-10 41.2 0.0 3.9e-10 39.9 0.0 1.7 2 0 0 2 2 1 1 PI3-kinase family, ras-binding domain Presenilin PF01080.17 ETO20254.1 - 0.0083 14.9 2.5 0.01 14.6 2.5 1.1 1 0 0 1 1 1 1 Presenilin RNA_pol_L_2 PF13656.6 ETO20254.1 - 0.039 13.7 0.0 0.11 12.3 0.0 1.8 1 0 0 1 1 1 0 RNA polymerase Rpb3/Rpb11 dimerisation domain Pex14_N PF04695.13 ETO20254.1 - 0.24 12.0 8.8 0.42 11.2 8.8 1.3 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Hydin_ADK PF17213.3 ETO20254.1 - 0.41 10.9 2.6 0.63 10.3 2.6 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Secretin_N_2 PF07655.13 ETO20254.1 - 0.62 10.7 13.1 1.1 9.8 13.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 ETO20254.1 - 0.68 8.2 7.9 0.9 7.8 7.9 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO20254.1 - 2.9 7.0 6.4 2.2 7.4 5.3 1.3 2 0 0 2 2 2 0 ZIP Zinc transporter ALMT PF11744.8 ETO20254.1 - 3.4 6.4 8.4 4.7 5.9 8.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter FAM60A PF15396.6 ETO20254.1 - 4.3 7.3 10.2 7.5 6.5 10.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A Band_3_cyto PF07565.13 ETO20254.1 - 9.1 6.0 7.7 14 5.4 7.7 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Feld-I_B PF09252.10 ETO20255.1 - 0.03 14.3 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Allergen Fel d I-B chain RNA_polI_A14 PF08203.11 ETO20256.1 - 0.088 13.5 0.8 0.62 10.8 0.1 2.4 2 1 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 PPTA PF01239.22 ETO20257.1 - 1.4e-21 75.5 10.0 1.1e-07 31.4 0.0 5.2 5 0 0 5 5 5 4 Protein prenyltransferase alpha subunit repeat Calcyon PF06387.11 ETO20258.1 - 0.053 13.5 0.9 0.083 12.9 0.9 1.3 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Ion_trans PF00520.31 ETO20259.1 - 0.068 12.4 2.1 0.1 11.8 2.1 1.2 1 0 0 1 1 1 0 Ion transport protein BUD22 PF09073.10 ETO20260.1 - 0.00093 18.6 28.7 0.042 13.2 2.7 2.1 2 0 0 2 2 2 2 BUD22 NOA36 PF06524.12 ETO20260.1 - 1.6 8.0 44.7 0.7 9.2 22.8 2.4 2 0 0 2 2 2 0 NOA36 protein SEA PF01390.20 ETO20262.1 - 0.011 15.8 3.7 0.019 15.1 0.5 2.2 1 1 1 2 2 2 0 SEA domain Z1 PF10593.9 ETO20262.1 - 0.014 15.0 1.0 0.015 14.8 1.0 1.1 1 0 0 1 1 1 0 Z1 domain DUF365 PF04033.12 ETO20262.1 - 0.028 14.7 0.4 0.043 14.1 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF365) HSBP1 PF06825.12 ETO20262.1 - 0.16 11.8 0.5 0.16 11.8 0.5 2.2 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Exonuc_VII_L PF02601.15 ETO20262.1 - 0.31 10.5 3.4 0.34 10.4 3.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit ZYG-11_interact PF05884.12 ETO20262.1 - 0.41 10.0 2.3 0.5 9.7 2.3 1.1 1 0 0 1 1 1 0 Interactor of ZYG-11 DUF1043 PF06295.12 ETO20262.1 - 1.3 9.0 9.7 1.3 9.0 8.8 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1043) dCache_3 PF14827.6 ETO20263.1 - 0.0014 18.3 0.0 0.0022 17.7 0.0 1.3 1 0 0 1 1 1 1 Double sensory domain of two-component sensor kinase Arm-DNA-bind_4 PF14657.6 ETO20264.1 - 0.18 11.5 8.5 0.46 10.3 8.5 1.6 1 0 0 1 1 1 0 Arm DNA-binding domain YfhO PF09586.10 ETO20265.1 - 0.12 10.6 2.5 0.14 10.4 2.5 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO DUF2756 PF10956.8 ETO20265.1 - 0.21 12.1 11.1 0.47 11.0 11.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) Ead_Ea22 PF13935.6 ETO20266.1 - 0.0055 17.4 1.2 0.0091 16.7 1.2 1.4 1 0 0 1 1 1 1 Ead/Ea22-like protein Pico_P2A PF00947.19 ETO20266.1 - 0.28 11.2 1.4 0.92 9.5 0.4 2.2 2 0 0 2 2 2 0 Picornavirus core protein 2A DUF4629 PF15442.6 ETO20266.1 - 3.3 7.9 18.8 0.26 11.5 13.5 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4629) WD40 PF00400.32 ETO20267.1 - 5.4e-16 58.7 9.4 1.3e-05 25.8 0.1 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO20267.1 - 0.0085 14.8 0.7 3.5 6.2 0.0 2.9 1 1 1 3 3 3 3 Nucleoporin Nup120/160 Macoilin PF09726.9 ETO20268.1 - 1.4 7.4 18.1 1.5 7.3 18.1 1.0 1 0 0 1 1 1 0 Macoilin family Ndc1_Nup PF09531.10 ETO20268.1 - 2.8 6.5 10.6 3.2 6.3 10.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup baeRF_family10 PF18854.1 ETO20269.1 - 0.15 12.3 0.1 0.23 11.7 0.1 1.2 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 10 AMP-binding PF00501.28 ETO20270.1 - 1.5e-24 86.4 0.1 2e-24 86.0 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO20270.1 - 6.7e-18 65.4 0.0 1e-17 64.8 0.0 1.3 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain PDEase_I PF00233.19 ETO20271.1 - 1.8e-76 257.0 0.3 1.8e-76 257.0 0.3 3.6 3 1 0 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase CCSAP PF15748.5 ETO20271.1 - 0.38 10.9 62.9 0.046 13.9 25.2 3.4 3 0 0 3 3 3 0 Centriole, cilia and spindle-associated AF-4 PF05110.13 ETO20271.1 - 0.46 8.5 55.0 0.028 12.5 44.4 2.1 2 0 0 2 2 2 0 AF-4 proto-oncoprotein DUF2052 PF09747.9 ETO20271.1 - 4.9 7.2 70.8 3.3 7.8 10.1 3.4 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) uDENN PF03456.18 ETO20272.1 - 8.7e-11 42.4 1.3 1.8e-10 41.4 1.3 1.6 1 0 0 1 1 1 1 uDENN domain SR-25 PF10500.9 ETO20272.1 - 0.35 10.4 10.3 0.51 9.9 10.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Dehydrin PF00257.19 ETO20272.1 - 0.65 10.5 7.7 1 9.9 7.7 1.5 1 1 0 1 1 1 0 Dehydrin UCH PF00443.29 ETO20273.1 - 3.6e-23 82.4 0.6 2.9e-20 72.9 0.0 3.4 1 1 1 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO20273.1 - 5.2e-12 46.0 0.4 2.1e-11 44.0 0.0 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_S24 PF00717.23 ETO20273.1 - 0.0073 16.2 0.2 13 5.8 0.0 3.7 3 0 0 3 3 3 1 Peptidase S24-like PIEZO PF15917.5 ETO20273.1 - 4.9 6.6 15.0 0.48 9.9 5.1 3.2 3 0 0 3 3 3 0 Piezo Skp1 PF01466.19 ETO20274.1 - 6.5e-08 32.6 0.0 1.7e-07 31.3 0.0 1.7 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETO20274.1 - 1.7e-05 24.9 3.6 2.4e-05 24.4 0.1 2.5 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain RasGEF PF00617.19 ETO20275.1 - 5.4e-36 124.4 0.2 7.7e-36 123.9 0.2 1.2 1 0 0 1 1 1 1 RasGEF domain NOA36 PF06524.12 ETO20278.1 - 1.2 8.4 19.0 2.3 7.4 19.0 1.5 1 0 0 1 1 1 0 NOA36 protein Nrap_D6 PF17407.2 ETO20279.1 - 0.039 14.2 0.1 8.5 6.6 0.1 2.7 2 1 0 2 2 2 0 Nrap protein domain 6 KA1 PF02149.19 ETO20279.1 - 0.042 13.7 0.0 0.12 12.2 0.0 1.8 1 0 0 1 1 1 0 Kinase associated domain 1 BAF1_ABF1 PF04684.13 ETO20279.1 - 0.14 11.2 17.1 0.19 10.7 17.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Macoilin PF09726.9 ETO20279.1 - 0.62 8.5 10.4 0.77 8.2 10.4 1.1 1 0 0 1 1 1 0 Macoilin family FXMRP1_C_core PF12235.8 ETO20281.1 - 0.012 16.3 6.1 0.019 15.6 6.1 1.2 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal Peptidase_S28 PF05577.12 ETO20282.1 - 3e-49 168.0 6.5 6.4e-44 150.4 7.4 3.1 2 1 0 2 2 2 2 Serine carboxypeptidase S28 Peptidase_S9 PF00326.21 ETO20282.1 - 0.0027 17.2 0.0 0.0062 16.0 0.0 1.5 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_6 PF12697.7 ETO20282.1 - 0.06 13.9 0.0 0.13 12.9 0.0 1.6 2 0 0 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 ETO20282.1 - 0.13 12.1 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO20282.1 - 0.14 11.4 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Ribosomal_S11 PF00411.19 ETO20283.1 - 5.5e-26 91.1 0.1 1.4e-22 80.2 0.0 2.6 2 0 0 2 2 2 2 Ribosomal protein S11 zf-4CXXC_R1 PF10497.9 ETO20283.1 - 4.1e-06 26.9 11.7 1.7e-05 25.0 11.7 2.0 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 RNA_pol_3_Rpc31 PF11705.8 ETO20283.1 - 9.5e-06 26.0 14.7 9.5e-06 26.0 14.7 2.9 2 1 0 2 2 2 1 DNA-directed RNA polymerase III subunit Rpc31 SDA1 PF05285.12 ETO20283.1 - 0.00016 21.2 18.1 0.00016 21.2 18.1 2.6 3 0 0 3 3 3 1 SDA1 PPP4R2 PF09184.11 ETO20283.1 - 0.0016 18.1 11.7 0.0016 18.1 11.7 3.6 2 1 1 3 3 3 1 PPP4R2 CAC1F_C PF16885.5 ETO20283.1 - 0.29 10.7 20.7 0.011 15.5 2.4 2.6 2 0 0 2 2 2 0 Voltage-gated calcium channel subunit alpha, C-term BUD22 PF09073.10 ETO20283.1 - 2.1 7.6 39.2 0.037 13.4 18.1 2.5 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 ETO20283.1 - 9.6 4.3 50.1 0.0053 15.0 25.3 2.1 2 0 0 2 2 2 0 Nop14-like family zf-C6H2 PF15801.5 ETO20284.1 - 3.1e-14 53.0 13.7 5.1e-14 52.3 13.7 1.4 1 0 0 1 1 1 1 zf-MYND-like zinc finger, mRNA-binding zf-MYND PF01753.18 ETO20284.1 - 0.00023 21.2 12.4 0.00045 20.3 12.4 1.5 1 0 0 1 1 1 1 MYND finger RR_TM4-6 PF06459.12 ETO20285.1 - 0.54 10.0 16.3 0.62 9.8 16.3 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO20285.1 - 0.74 9.0 6.9 0.81 8.8 6.9 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO20285.1 - 1 8.1 7.6 1.1 7.9 7.6 1.0 1 0 0 1 1 1 0 Presenilin TRAP_alpha PF03896.16 ETO20285.1 - 1.2 8.2 7.0 1.4 8.1 7.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Vfa1 PF08432.10 ETO20285.1 - 2.8 8.2 19.3 3.3 8.0 19.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 ETO20285.1 - 3 8.3 10.1 3.7 8.0 10.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSG2 PF16965.5 ETO20285.1 - 3.7 6.4 4.3 3.8 6.3 4.3 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Sporozoite_P67 PF05642.11 ETO20285.1 - 4.5 5.2 8.6 4.9 5.1 8.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Borrelia_P83 PF05262.11 ETO20285.1 - 4.7 5.6 20.1 5.3 5.4 20.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein ALMT PF11744.8 ETO20285.1 - 7 5.4 8.6 7.8 5.2 8.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 ETO20285.1 - 7.5 5.5 6.1 8.2 5.4 6.1 1.0 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 ETO20285.1 - 7.9 4.6 14.9 8.6 4.5 14.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO20285.1 - 9.7 5.9 10.6 12 5.6 10.6 1.3 1 0 0 1 1 1 0 Connexin DUF4407 PF14362.6 ETO20286.1 - 0.0067 15.8 0.2 0.0067 15.8 0.2 5.4 5 1 0 5 5 5 1 Domain of unknown function (DUF4407) MerR-DNA-bind PF09278.11 ETO20286.1 - 0.18 12.4 0.0 0.18 12.4 0.0 5.5 8 0 0 8 8 8 0 MerR, DNA binding F-box-like_2 PF13013.6 ETO20286.1 - 0.57 10.2 5.1 2.8 8.0 0.1 3.7 3 0 0 3 3 3 0 F-box-like domain Ion_trans PF00520.31 ETO20287.1 - 5.4e-10 38.9 1.9 5.4e-10 38.9 1.9 1.8 1 1 0 2 2 2 1 Ion transport protein Ion_trans_2 PF07885.16 ETO20287.1 - 2.2e-09 37.1 10.8 2.2e-09 37.1 10.8 2.3 2 1 1 3 3 3 1 Ion channel CPBP PF02517.16 ETO20287.1 - 0.2 12.0 2.8 0.72 10.3 2.7 1.9 1 1 0 1 1 1 0 CPBP intramembrane metalloprotease SecE PF00584.20 ETO20287.1 - 0.98 9.4 0.1 0.98 9.4 0.1 2.5 2 0 0 2 2 2 0 SecE/Sec61-gamma subunits of protein translocation complex Ins134_P3_kin PF05770.11 ETO20288.1 - 7.7e-10 38.6 0.1 1e-09 38.2 0.1 1.4 1 1 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain TTL PF03133.15 ETO20288.1 - 0.003 16.7 0.0 0.0033 16.6 0.0 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family DUF575 PF04746.12 ETO20289.1 - 0.034 14.4 0.0 0.064 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF575) YhcG_C PF06250.11 ETO20289.1 - 0.079 12.8 0.6 11 5.8 0.0 2.3 1 1 1 2 2 2 0 YhcG PDDEXK nuclease domain DUF3439 PF11921.8 ETO20290.1 - 4.1 7.4 17.0 2.7 8.0 2.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Asp_Arg_Hydrox PF05118.15 ETO20291.1 - 0.14 12.0 1.6 0.13 12.1 0.7 1.4 1 1 0 1 1 1 0 Aspartyl/Asparaginyl beta-hydroxylase Afi1 PF07792.12 ETO20291.1 - 0.77 10.2 7.0 1.1 9.7 7.0 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking YMF19 PF02326.15 ETO20291.1 - 10 7.0 22.7 4.8 8.0 7.8 2.4 1 1 1 2 2 2 0 Plant ATP synthase F0 Methyltransf_11 PF08241.12 ETO20297.1 - 9.3e-09 35.8 0.0 1.5e-08 35.2 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO20297.1 - 6.5e-07 29.3 0.0 9.9e-07 28.7 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO20297.1 - 8.1e-05 23.3 0.0 0.00013 22.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_15 PF09445.10 ETO20297.1 - 0.0014 18.3 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_23 PF13489.6 ETO20297.1 - 0.0014 18.5 0.0 0.0019 18.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain N2227 PF07942.12 ETO20297.1 - 0.0049 16.1 0.1 0.0074 15.5 0.1 1.2 1 0 0 1 1 1 1 N2227-like protein Ubie_methyltran PF01209.18 ETO20297.1 - 0.016 14.6 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ETO20297.1 - 0.021 15.5 0.0 0.036 14.8 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain NodS PF05401.11 ETO20297.1 - 0.044 13.4 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Nodulation protein S (NodS) G-alpha PF00503.20 ETO20299.1 - 2.8e-70 237.3 12.2 3.7e-70 236.9 12.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO20299.1 - 1.1e-09 37.9 0.1 2.3e-09 36.9 0.1 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF443 PF04276.12 ETO20300.1 - 0.057 13.2 0.6 0.057 13.2 0.6 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF443) DUF2207 PF09972.9 ETO20300.1 - 0.11 11.2 0.6 0.2 10.4 0.6 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2304 PF10066.9 ETO20300.1 - 0.51 10.6 5.0 0.11 12.7 0.9 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Prok-E2_B PF14461.6 ETO20301.1 - 0.25 11.0 1.9 5.2 6.8 0.2 2.4 2 0 0 2 2 2 0 Prokaryotic E2 family B Secretin_N_2 PF07655.13 ETO20302.1 - 0.62 10.6 13.7 0.095 13.3 7.0 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain WD40 PF00400.32 ETO20303.1 - 3.4e-61 201.8 16.9 1.3e-09 38.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20303.1 - 1.3e-22 79.9 1.5 0.003 17.8 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20303.1 - 3.6e-16 59.0 0.6 0.00012 21.2 0.0 5.8 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO20303.1 - 1.2e-10 41.6 0.1 0.003 17.5 0.0 3.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO20303.1 - 5.8e-09 35.7 0.0 0.0058 16.0 0.0 3.0 2 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO20303.1 - 1.2e-07 30.7 0.4 0.029 12.9 0.0 3.2 1 1 1 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO20303.1 - 7.1e-06 24.9 7.5 0.07 11.8 0.1 4.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO20303.1 - 1.2e-05 25.1 3.0 6.3 6.9 0.0 5.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO20303.1 - 5.9e-05 22.3 0.2 0.095 11.7 0.0 2.5 1 1 2 3 3 3 2 Coatomer WD associated region Gmad1 PF10647.9 ETO20303.1 - 6.1e-05 22.9 0.2 0.15 11.7 0.1 2.7 2 1 0 3 3 3 2 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.6 ETO20303.1 - 0.00034 20.0 1.7 0.14 11.4 0.0 4.1 1 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DUF1513 PF07433.11 ETO20303.1 - 0.0014 17.7 0.4 0.75 8.8 0.0 3.6 1 1 4 5 5 5 1 Protein of unknown function (DUF1513) Nucleoporin_N PF08801.11 ETO20303.1 - 0.0093 14.8 3.7 3.3 6.3 0.4 3.9 1 1 3 5 5 5 2 Nup133 N terminal like VID27 PF08553.10 ETO20303.1 - 0.035 13.2 0.1 3.7 6.5 0.0 2.7 1 1 0 2 2 2 0 VID27 C-terminal WD40-like domain HPS3_N PF14761.6 ETO20303.1 - 0.042 13.4 0.0 0.6 9.6 0.0 2.3 2 1 0 2 2 2 0 Hermansky-Pudlak syndrome 3 Frtz PF11768.8 ETO20303.1 - 0.097 11.0 0.0 0.31 9.3 0.0 1.8 1 1 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF386 PF04074.12 ETO20303.1 - 0.16 11.9 0.0 0.53 10.2 0.0 1.8 1 1 1 2 2 2 0 YhcH/YjgK/YiaL Proteasome_A_N PF10584.9 ETO20303.1 - 0.18 11.5 8.1 9.6 6.0 0.1 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature EamA PF00892.20 ETO20304.1 - 1.8e-09 37.9 9.2 5.5e-07 29.8 6.3 2.6 3 0 0 3 3 3 2 EamA-like transporter family PUNUT PF16913.5 ETO20304.1 - 7.8e-05 22.0 3.6 0.00016 21.0 0.8 2.0 2 0 0 2 2 2 1 Purine nucleobase transmembrane transport Secretin_N_2 PF07655.13 ETO20304.1 - 0.014 16.0 2.4 0.026 15.0 2.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain TPT PF03151.16 ETO20304.1 - 0.015 14.6 1.3 0.12 11.8 0.6 2.1 2 0 0 2 2 2 0 Triose-phosphate Transporter family DUF2157 PF09925.9 ETO20304.1 - 0.094 12.5 1.4 0.56 10.0 0.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2157) Pox_Ag35 PF03286.14 ETO20304.1 - 0.49 10.2 4.0 0.68 9.7 4.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 ETO20304.1 - 2.1 7.4 7.4 2.6 7.1 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sporozoite_P67 PF05642.11 ETO20304.1 - 5.8 4.9 5.8 7.9 4.4 5.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen L_HMGIC_fpl PF10242.9 ETO20305.1 - 0.29 11.3 5.1 0.084 13.1 1.7 1.8 2 0 0 2 2 2 0 Lipoma HMGIC fusion partner-like protein DUF5436 PF17504.2 ETO20305.1 - 0.59 10.5 10.0 0.26 11.7 3.7 2.4 1 1 1 2 2 2 0 Family of unknown function (DUF5436) U3_snoRNA_assoc PF08297.11 ETO20305.1 - 0.73 10.6 4.8 0.58 10.9 2.5 1.8 1 1 1 2 2 2 0 U3 snoRNA associated Phage_holin_3_6 PF07332.11 ETO20306.1 - 0.075 13.1 4.5 0.099 12.7 1.0 2.2 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF2975 PF11188.8 ETO20306.1 - 0.18 11.7 0.3 0.18 11.7 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) Pkinase PF00069.25 ETO20307.1 - 7.1e-17 61.6 0.0 9.5e-17 61.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20307.1 - 5.5e-07 29.1 0.0 7.4e-07 28.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Myb_Cef PF11831.8 ETO20307.1 - 0.019 14.6 0.2 0.021 14.4 0.2 1.2 1 0 0 1 1 1 0 pre-mRNA splicing factor component Pkinase PF00069.25 ETO20308.1 - 6.8e-33 114.1 1.5 6.8e-33 114.1 1.5 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20308.1 - 5.5e-25 88.1 2.3 6.8e-25 87.8 2.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 ETO20308.1 - 0.0089 16.2 0.1 0.082 13.1 0.1 2.2 1 1 1 2 2 2 1 ABC1 family Pkinase PF00069.25 ETO20309.1 - 0.01 15.2 0.3 0.024 14.0 0.0 1.7 2 0 0 2 2 2 0 Protein kinase domain YebO PF13974.6 ETO20309.1 - 0.14 12.2 6.7 0.11 12.6 4.2 2.0 2 0 0 2 2 2 0 YebO-like protein DUF4504 PF14953.6 ETO20310.1 - 0.0041 16.6 0.0 0.0046 16.4 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4504) IFT81_CH PF18383.1 ETO20310.1 - 0.027 14.8 0.3 0.92 9.8 0.1 2.2 2 0 0 2 2 2 0 Intraflagellar transport 81 calponin homology domain DNA_pol_phi PF04931.13 ETO20310.1 - 0.036 12.2 4.8 0.045 11.9 4.8 1.0 1 0 0 1 1 1 0 DNA polymerase phi HD_3 PF13023.6 ETO20311.1 - 9e-24 84.3 2.7 9.9e-24 84.1 2.7 1.0 1 0 0 1 1 1 1 HD domain HD_2 PF12917.7 ETO20311.1 - 1.1e-09 38.4 1.6 1.1e-09 38.3 1.6 1.0 1 0 0 1 1 1 1 HD containing hydrolase-like enzyme HD PF01966.22 ETO20311.1 - 1.8e-05 24.9 0.2 2.1e-05 24.7 0.2 1.1 1 0 0 1 1 1 1 HD domain AAA PF00004.29 ETO20312.1 - 2.8e-42 144.3 0.0 4.8e-42 143.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO20312.1 - 3.8e-11 42.6 0.0 7.3e-11 41.7 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain FtsH_ext PF06480.15 ETO20312.1 - 5.4e-08 33.1 0.2 4.5e-07 30.2 0.0 2.6 2 0 0 2 2 2 1 FtsH Extracellular AAA_22 PF13401.6 ETO20312.1 - 0.00011 22.4 0.0 0.041 14.2 0.0 2.4 1 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO20312.1 - 0.00046 20.2 0.0 0.0018 18.3 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO20312.1 - 0.00063 20.2 0.1 0.018 15.5 0.1 2.4 1 1 0 2 2 2 1 AAA ATPase domain RuvB_N PF05496.12 ETO20312.1 - 0.012 15.4 0.0 0.026 14.3 0.0 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ETO20312.1 - 0.015 15.5 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain TIP49 PF06068.13 ETO20312.1 - 0.019 14.2 0.0 0.029 13.6 0.0 1.3 1 0 0 1 1 1 0 TIP49 P-loop domain IstB_IS21 PF01695.17 ETO20312.1 - 0.035 13.8 0.0 0.063 13.0 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO20312.1 - 0.04 13.3 0.2 0.092 12.1 0.2 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF22 PF01629.16 ETO20312.1 - 0.054 13.2 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF22 AAA_18 PF13238.6 ETO20312.1 - 0.06 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ETO20312.1 - 0.06 13.4 0.0 0.12 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain ERO1 PF04137.15 ETO20312.1 - 0.065 12.4 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) AAA_2 PF07724.14 ETO20312.1 - 0.099 12.7 0.1 0.8 9.8 0.1 2.3 1 1 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_7 PF12775.7 ETO20312.1 - 0.18 11.3 0.1 0.55 9.7 0.1 1.8 1 1 0 1 1 1 0 P-loop containing dynein motor region Apt1 PF10351.9 ETO20312.1 - 2.5 6.8 6.9 6 5.6 6.9 1.5 1 0 0 1 1 1 0 Golgi-body localisation protein domain Cation_ATPase_N PF00690.26 ETO20313.1 - 1.1e-05 25.0 0.4 7.2e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 Cation transporter/ATPase, N-terminus Cupin_8 PF13621.6 ETO20314.1 - 4.7e-09 36.3 0.6 4.7e-09 36.3 0.6 1.5 2 0 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 ETO20314.1 - 0.00015 21.4 0.2 0.00023 20.7 0.1 1.4 1 1 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 ETO20315.1 - 1.4e-07 31.5 0.1 1.7e-07 31.2 0.1 1.1 1 0 0 1 1 1 1 Cupin-like domain Gti1_Pac2 PF09729.9 ETO20315.1 - 0.021 15.0 2.2 0.026 14.6 2.2 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family Rhodanese PF00581.20 ETO20315.1 - 0.074 13.6 0.0 0.21 12.1 0.0 1.7 1 1 1 2 2 2 0 Rhodanese-like domain Tfb4 PF03850.14 ETO20315.1 - 0.19 11.2 1.2 0.23 10.9 1.2 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 DUF4660 PF15559.6 ETO20315.1 - 0.44 10.9 7.1 0.72 10.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4660) Pkinase PF00069.25 ETO20317.1 - 6.9e-34 117.4 0.0 1.5e-33 116.3 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20317.1 - 2.4e-11 43.4 0.0 4.1e-11 42.6 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase TMEM214 PF10151.9 ETO20319.1 - 0.017 13.7 3.9 0.017 13.6 3.9 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Tho2 PF11262.8 ETO20319.1 - 0.034 13.4 2.9 0.039 13.2 2.9 1.0 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 DUF3915 PF13054.6 ETO20319.1 - 0.64 10.0 2.8 0.78 9.7 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Glycos_transf_1 PF00534.20 ETO20320.1 - 3.1e-07 30.1 0.0 5.4e-07 29.3 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO20320.1 - 0.00046 20.6 0.0 0.00095 19.6 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 RPN2_C PF18004.1 ETO20321.1 - 7.2 6.5 11.3 8.5 6.3 1.1 2.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Mito_carr PF00153.27 ETO20322.1 - 3.9e-29 100.4 3.8 7.4e-14 51.4 0.3 2.4 3 0 0 3 3 3 2 Mitochondrial carrier protein Serine_protease PF18405.1 ETO20322.1 - 0.006 15.8 0.2 0.65 9.1 0.0 2.1 2 0 0 2 2 2 2 Gammaproteobacterial serine protease Myosin_head PF00063.21 ETO20323.1 - 3e-19 68.8 0.0 6.3e-19 67.7 0.0 1.5 1 0 0 1 1 1 1 Myosin head (motor domain) Aldedh PF00171.22 ETO20324.1 - 2.4e-35 122.0 0.1 2.9e-35 121.7 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETO20324.1 - 0.00024 20.3 0.1 0.00031 19.9 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA reductase (LuxC) BAR_3 PF16746.5 ETO20324.1 - 0.019 14.7 0.1 0.024 14.3 0.1 1.1 1 0 0 1 1 1 0 BAR domain of APPL family Calreticulin PF00262.18 ETO20325.1 - 4.9e-28 98.0 26.0 3.1e-19 69.1 0.1 2.3 2 1 1 3 3 3 2 Calreticulin family Spore_YhaL PF14147.6 ETO20325.1 - 0.59 9.9 3.7 0.89 9.3 0.1 2.9 3 1 1 4 4 4 0 Sporulation protein YhaL Presenilin PF01080.17 ETO20326.1 - 0.089 11.5 23.7 0.096 11.4 12.8 2.1 2 0 0 2 2 2 0 Presenilin Adaptin_binding PF10199.9 ETO20326.1 - 8.3 7.0 21.9 0.22 12.1 3.4 3.1 3 0 0 3 3 3 0 Alpha and gamma adaptin binding protein p34 PH PF00169.29 ETO20327.1 - 1.3e-16 61.0 2.4 1.3e-16 61.0 2.4 1.5 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO20327.1 - 9.9e-08 32.2 1.4 1.6e-07 31.5 1.4 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain WD40 PF00400.32 ETO20327.1 - 0.0017 19.1 0.1 0.0044 17.8 0.1 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat PH_11 PF15413.6 ETO20327.1 - 0.0028 18.0 11.4 0.032 14.6 9.2 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 ETO20327.1 - 0.043 14.2 0.2 0.086 13.2 0.2 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region Vps16_C PF04840.12 ETO20327.1 - 0.045 12.8 0.1 0.067 12.2 0.1 1.2 1 0 0 1 1 1 0 Vps16, C-terminal region Mucin PF01456.17 ETO20327.1 - 0.97 9.4 21.2 1.5 8.8 21.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein PALB2_WD40 PF16756.5 ETO20328.1 - 0.029 13.3 0.0 0.043 12.8 0.0 1.2 1 0 0 1 1 1 0 Partner and localizer of BRCA2 WD40 domain Rep_fac-A_C PF08646.10 ETO20329.1 - 0.001 18.9 0.0 0.0016 18.2 0.0 1.3 1 0 0 1 1 1 1 Replication factor-A C terminal domain DUF4550 PF15084.6 ETO20329.1 - 0.065 13.7 0.1 0.11 12.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4550) tRNA_anti-codon PF01336.25 ETO20329.1 - 0.09 12.8 0.8 0.24 11.4 0.8 1.8 1 1 0 1 1 1 0 OB-fold nucleic acid binding domain POT1PC PF16686.5 ETO20330.1 - 2.1e-06 27.7 5.4 0.0019 18.1 1.0 3.1 2 1 0 2 2 2 2 ssDNA-binding domain of telomere protection protein SART-1 PF03343.13 ETO20330.1 - 0.00085 18.0 0.0 0.0014 17.3 0.0 1.3 1 1 0 1 1 1 1 SART-1 family RPEL PF02755.15 ETO20331.1 - 1.2e-08 34.3 2.5 0.0043 16.7 0.1 3.8 3 0 0 3 3 3 2 RPEL repeat CPSF100_C PF13299.6 ETO20331.1 - 0.016 15.4 6.4 0.016 15.4 6.4 2.5 1 1 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF4611 PF15387.6 ETO20331.1 - 0.04 14.1 10.4 0.15 12.3 10.4 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 ETO20331.1 - 0.34 11.3 19.4 0.94 9.9 18.7 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.11 ETO20331.1 - 0.75 7.8 8.0 1.1 7.3 8.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ETO20331.1 - 1.4 8.2 18.7 0.081 12.2 13.1 1.7 2 0 0 2 2 2 0 NOA36 protein FAM176 PF14851.6 ETO20331.1 - 3.9 7.1 14.5 0.4 10.3 6.7 2.6 2 0 0 2 2 2 0 FAM176 family FlaC_arch PF05377.11 ETO20331.1 - 6.6 7.2 13.1 10 6.6 1.1 3.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Aldedh PF00171.22 ETO20333.1 - 5.1e-74 249.4 0.1 3.3e-36 124.8 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family TMEM125 PF15109.6 ETO20333.1 - 0.06 13.7 0.0 0.12 12.8 0.0 1.5 1 0 0 1 1 1 0 TMEM125 protein family HPS3_N PF14761.6 ETO20335.1 - 0.081 12.4 3.3 4.8 6.7 0.0 3.3 2 1 0 3 3 3 0 Hermansky-Pudlak syndrome 3 TPR_12 PF13424.6 ETO20337.1 - 5.7e-27 93.8 1.4 9e-11 41.9 0.1 2.6 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO20337.1 - 3.8e-18 64.1 3.0 3.3e-06 26.7 0.1 4.6 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO20337.1 - 5.9e-16 57.5 13.1 1.7e-05 24.4 0.4 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO20337.1 - 3e-15 55.0 10.5 0.0041 17.1 0.1 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO20337.1 - 4.3e-14 51.5 9.7 0.00041 20.3 0.3 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO20337.1 - 2.2e-08 33.7 0.1 0.088 12.7 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO20337.1 - 4.6e-07 30.1 1.4 1 10.1 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO20337.1 - 1.3e-06 28.7 0.0 2.9 9.0 0.0 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO20337.1 - 2e-06 28.3 0.2 1 10.1 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 ETO20337.1 - 2.1e-06 27.4 0.1 0.0021 17.5 0.0 2.2 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_3 PF07720.12 ETO20337.1 - 0.0001 22.2 12.2 0.00039 20.3 0.8 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO20337.1 - 0.00016 21.3 12.3 0.38 10.5 0.1 5.1 4 1 1 5 5 5 2 TPR repeat MIT PF04212.18 ETO20337.1 - 0.00051 20.1 5.2 4.9 7.3 0.0 4.2 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain Mob_Pre PF01076.19 ETO20337.1 - 0.039 13.8 1.7 19 5.0 0.0 3.1 3 0 0 3 3 3 0 Plasmid recombination enzyme DUF2225 PF09986.9 ETO20337.1 - 0.041 13.6 2.7 0.059 13.1 1.1 1.9 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) SusF_SusE PF16411.5 ETO20337.1 - 0.11 13.0 0.0 0.32 11.5 0.0 1.9 1 1 0 1 1 1 0 Outer membrane protein SusF_SusE WD40 PF00400.32 ETO20338.1 - 5.7e-16 58.6 15.5 5e-07 30.3 0.5 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20338.1 - 0.00055 20.2 0.4 1.3 9.3 0.0 3.1 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20338.1 - 0.00091 18.0 3.0 0.54 8.8 0.1 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 RicinB_lectin_2 PF14200.6 ETO20338.1 - 0.03 15.1 0.9 0.3 11.8 0.2 2.1 1 1 1 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Aldose_epim PF01263.20 ETO20339.1 - 1.9e-18 66.8 1.2 8.3e-13 48.3 0.3 2.1 2 0 0 2 2 2 2 Aldose 1-epimerase PdaC PF13739.6 ETO20339.1 - 0.055 14.5 2.1 0.071 14.1 0.2 2.0 2 0 0 2 2 2 0 Deacetylase PdaC Sod_Fe_C PF02777.18 ETO20340.1 - 4.1e-42 142.5 0.7 5.6e-42 142.1 0.7 1.2 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Kelch_6 PF13964.6 ETO20341.1 - 9.4e-08 32.1 0.2 0.00023 21.4 0.1 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO20341.1 - 8.8e-06 25.2 4.3 0.00042 19.9 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO20341.1 - 0.00066 19.6 0.2 0.088 12.8 0.1 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO20341.1 - 0.0046 17.2 0.2 0.024 14.9 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO20341.1 - 0.0058 16.6 0.1 1 9.4 0.1 3.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO20341.1 - 0.0069 16.3 3.0 0.24 11.4 0.2 3.3 4 0 0 4 4 4 1 Kelch motif S100PBPR PF15427.6 ETO20341.1 - 0.04 13.2 0.0 0.082 12.2 0.0 1.4 1 0 0 1 1 1 0 S100P-binding protein WD40 PF00400.32 ETO20342.1 - 3.6e-46 154.2 11.3 4.8e-11 43.0 0.2 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20342.1 - 5.1e-15 55.6 0.6 0.0003 21.0 0.0 5.8 1 1 6 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20342.1 - 6.3e-12 45.1 0.8 0.013 14.4 0.0 5.0 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO20342.1 - 3.4e-07 30.0 3.2 0.43 10.6 0.3 5.3 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO20342.1 - 5.8e-05 22.6 4.5 0.01 15.2 0.2 3.0 1 1 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO20342.1 - 0.00012 20.7 0.1 0.16 10.5 0.0 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain eIF2A PF08662.11 ETO20342.1 - 0.00019 21.4 0.0 0.17 11.8 0.0 2.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Proteasome_A_N PF10584.9 ETO20342.1 - 0.0019 17.8 0.7 2.8 7.7 0.0 3.7 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETO20342.1 - 0.0061 16.2 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain Nup160 PF11715.8 ETO20342.1 - 0.011 14.4 6.3 0.91 8.1 1.5 3.9 1 1 0 2 2 2 0 Nucleoporin Nup120/160 Frtz PF11768.8 ETO20342.1 - 0.039 12.3 0.1 0.078 11.3 0.1 1.6 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz SGL PF08450.12 ETO20342.1 - 0.052 13.1 0.1 0.33 10.5 0.1 2.2 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DUF5046 PF16465.5 ETO20342.1 - 0.055 12.9 0.2 0.25 10.8 0.0 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF5046) DUF4999 PF16390.5 ETO20342.1 - 0.057 13.7 0.5 5.2 7.4 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function PP2C PF00481.21 ETO20343.1 - 3.1e-31 108.9 0.0 2.9e-27 95.9 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C PP2C_2 PF13672.6 ETO20343.1 - 0.013 15.1 0.0 11 5.5 0.0 3.2 3 0 0 3 3 3 0 Protein phosphatase 2C PP28 PF10252.9 ETO20343.1 - 0.2 12.1 3.7 0.47 10.9 3.7 1.6 1 0 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 PBP1_TM PF14812.6 ETO20344.1 - 0.48 10.8 18.5 0.16 12.4 5.8 2.8 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal NESP55 PF06390.12 ETO20344.1 - 9 5.8 8.0 3.4 7.2 0.0 2.5 3 0 0 3 3 3 0 Neuroendocrine-specific golgi protein P55 (NESP55) Striatin PF08232.12 ETO20346.1 - 4.5 7.9 10.4 5.1 7.7 0.2 2.3 2 0 0 2 2 2 0 Striatin family SR-25 PF10500.9 ETO20347.1 - 0.011 15.3 2.2 0.011 15.3 2.2 1.6 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4611 PF15387.6 ETO20347.1 - 0.026 14.7 0.2 0.06 13.6 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Dehydrin PF00257.19 ETO20347.1 - 0.33 11.5 3.2 0.63 10.6 3.2 1.4 1 0 0 1 1 1 0 Dehydrin Metallophos PF00149.28 ETO20348.1 - 5.3e-37 128.3 0.2 6.9e-37 127.9 0.2 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO20348.1 - 5.2e-14 52.4 1.3 9.1e-14 51.6 1.3 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Tetraspanin PF00335.20 ETO20349.1 - 0.066 12.9 0.2 0.1 12.3 0.2 1.3 1 0 0 1 1 1 0 Tetraspanin family CENP-O PF09496.10 ETO20349.1 - 0.099 12.6 1.1 0.12 12.4 1.1 1.2 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component PTPS PF01242.19 ETO20349.1 - 0.11 12.5 0.6 0.2 11.6 0.5 1.5 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase PRP9_N PF16958.5 ETO20349.1 - 1.5 8.8 9.2 0.085 12.9 4.2 1.5 2 0 0 2 2 2 0 Pre-mRNA-splicing factor PRP9 N-terminus SSP160 PF06933.11 ETO20350.1 - 0.0016 16.8 11.5 0.0016 16.7 11.5 1.1 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO20350.1 - 0.0017 18.4 16.3 0.002 18.1 16.3 1.3 1 0 0 1 1 1 1 Mucin-like glycoprotein DUF3439 PF11921.8 ETO20350.1 - 0.11 12.5 13.4 0.17 11.9 13.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO20350.1 - 0.14 10.2 9.4 0.14 10.1 9.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein NST1 PF13945.6 ETO20350.1 - 1.6 8.8 7.9 2.8 8.0 7.9 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Macoilin PF09726.9 ETO20350.1 - 7 5.1 9.4 8 4.9 9.4 1.0 1 0 0 1 1 1 0 Macoilin family PulG PF11773.8 ETO20351.1 - 0.023 14.5 0.8 0.088 12.6 0.8 2.0 1 0 0 1 1 1 0 Type II secretory pathway pseudopilin RdRP PF05183.12 ETO20353.1 - 6.2e-16 58.2 0.2 1.2e-10 40.7 0.0 2.3 2 1 0 2 2 2 2 RNA dependent RNA polymerase zf-LITAF-like PF10601.9 ETO20353.1 - 0.0018 18.5 3.2 0.0018 18.5 3.2 1.7 2 0 0 2 2 2 1 LITAF-like zinc ribbon domain SRP1_TIP1 PF00660.17 ETO20353.1 - 0.14 12.3 1.1 3.3 7.8 0.2 2.3 2 0 0 2 2 2 0 Seripauperin and TIP1 family GCP_C_terminal PF04130.13 ETO20353.1 - 0.15 11.4 3.7 0.092 12.2 1.8 1.7 1 1 1 2 2 2 0 Gamma tubulin complex component C-terminal zf-TRAF PF02176.18 ETO20354.1 - 3.1e-12 47.0 37.8 1.4e-06 28.9 7.1 5.5 1 1 5 6 6 6 3 TRAF-type zinc finger zf-C3HC4 PF00097.25 ETO20354.1 - 4.1e-09 36.1 11.6 4.1e-09 36.1 11.6 3.4 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO20354.1 - 6.5e-08 32.3 14.8 6.5e-08 32.3 14.8 3.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO20354.1 - 8.3e-07 28.9 9.1 4.2e-06 26.7 9.1 2.3 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ETO20354.1 - 4.4e-06 26.5 7.9 4.4e-06 26.5 7.9 2.9 3 1 0 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO20354.1 - 3.3e-05 24.1 13.8 3.3e-05 24.1 13.8 3.5 3 1 0 3 3 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 ETO20354.1 - 0.011 15.9 10.1 0.011 15.9 10.1 3.4 2 1 1 3 3 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ETO20354.1 - 0.012 15.4 3.9 0.012 15.4 3.9 2.0 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_5 PF14634.6 ETO20354.1 - 0.013 15.5 15.3 0.013 15.5 15.3 3.8 2 2 1 3 3 2 0 zinc-RING finger domain Sina PF03145.16 ETO20354.1 - 0.017 15.1 4.7 0.017 15.1 4.7 3.6 1 1 3 4 4 4 0 Seven in absentia protein family zf-TRAF_2 PF15965.5 ETO20354.1 - 0.097 13.1 0.1 0.097 13.1 0.1 4.3 1 1 2 4 4 4 0 TRAF-like zinc-finger zf-U11-48K PF05253.12 ETO20354.1 - 1.4 8.9 10.3 5.9 6.9 0.0 4.9 5 0 0 5 5 5 0 U11-48K-like CHHC zinc finger zf-Nse PF11789.8 ETO20354.1 - 5.6 6.9 16.3 0.04 13.7 6.6 2.4 3 0 0 3 3 3 0 Zinc-finger of the MIZ type in Nse subunit SPRY PF00622.28 ETO20355.1 - 0.015 15.4 0.0 0.033 14.3 0.0 1.5 1 0 0 1 1 1 0 SPRY domain HhH-GPD PF00730.25 ETO20355.1 - 0.086 13.3 0.0 17 5.9 0.0 2.2 1 1 1 2 2 2 0 HhH-GPD superfamily base excision DNA repair protein CPSF73-100_C PF11718.8 ETO20356.1 - 1.2 8.6 9.3 0.47 10.0 0.2 2.3 2 1 0 2 2 2 0 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term Mucin PF01456.17 ETO20357.1 - 7.3 6.6 19.7 14 5.7 19.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Peptidase_C14 PF00656.22 ETO20358.1 - 1.7e-12 47.8 0.8 2.4e-12 47.3 0.8 1.2 1 0 0 1 1 1 1 Caspase domain NTF2 PF02136.20 ETO20358.1 - 0.039 14.5 0.1 0.095 13.3 0.1 1.7 2 0 0 2 2 2 0 Nuclear transport factor 2 (NTF2) domain NPV_P10 PF05531.12 ETO20359.1 - 0.00039 20.8 9.3 0.07 13.6 2.9 2.5 3 0 0 3 3 2 2 Nucleopolyhedrovirus P10 protein TRAPPC-Trs85 PF12739.7 ETO20359.1 - 0.0012 17.9 0.3 0.0022 17.0 0.2 1.5 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit DUF4407 PF14362.6 ETO20359.1 - 0.017 14.5 8.8 0.025 13.9 8.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cep57_CLD PF14073.6 ETO20359.1 - 0.027 14.5 6.7 0.027 14.5 6.7 2.3 1 1 1 2 2 2 0 Centrosome localisation domain of Cep57 Tup_N PF08581.10 ETO20359.1 - 0.035 14.4 4.8 0.035 14.4 4.8 2.4 2 1 0 2 2 2 0 Tup N-terminal DUF883 PF05957.13 ETO20359.1 - 0.061 13.9 5.8 2.1 9.0 1.5 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) KfrA_N PF11740.8 ETO20359.1 - 0.085 13.5 2.1 0.39 11.4 0.3 2.1 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term FlaC_arch PF05377.11 ETO20359.1 - 0.093 13.1 10.3 2.4 8.6 3.2 3.0 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF2207 PF09972.9 ETO20359.1 - 0.097 11.4 1.6 0.13 11.0 1.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Baculo_PEP_C PF04513.12 ETO20359.1 - 0.12 12.4 3.9 6.1 6.9 0.6 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3800 PF12686.7 ETO20359.1 - 0.33 11.6 1.7 0.47 11.1 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) DUF1664 PF07889.12 ETO20359.1 - 0.65 10.1 13.4 0.3 11.1 6.3 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) CorA PF01544.18 ETO20359.1 - 1.4 8.2 6.1 2 7.7 6.1 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Nbl1_Borealin_N PF10444.9 ETO20359.1 - 2.5 7.8 10.3 8.4 6.1 0.9 2.8 2 0 0 2 2 2 0 Nbl1 / Borealin N terminal TPR_MLP1_2 PF07926.12 ETO20359.1 - 3.1 7.9 22.5 0.72 9.9 8.9 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein ZapA PF05164.13 ETO20359.1 - 3.4 8.2 9.3 35 4.9 9.7 2.4 1 1 0 1 1 1 0 Cell division protein ZapA ACCA PF03255.14 ETO20359.1 - 6.2 6.7 15.3 1.7 8.6 8.0 2.3 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit CSN5_C PF18323.1 ETO20359.1 - 6.5 7.7 12.2 14 6.7 11.8 1.8 1 1 0 1 1 1 0 Cop9 signalosome subunit 5 C-terminal domain DUF2203 PF09969.9 ETO20359.1 - 6.5 7.5 11.7 2.9e+03 -1.0 11.7 2.3 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Exonuc_VII_L PF02601.15 ETO20359.1 - 7.4 6.0 18.5 16 4.9 18.5 1.5 1 1 0 1 1 1 0 Exonuclease VII, large subunit STAT_alpha PF01017.20 ETO20362.1 - 0.00098 19.1 6.1 0.0023 17.8 5.6 1.7 1 1 1 2 2 2 1 STAT protein, all-alpha domain TPR_MLP1_2 PF07926.12 ETO20362.1 - 0.0039 17.2 13.0 0.28 11.2 9.9 2.1 2 0 0 2 2 2 2 TPR/MLP1/MLP2-like protein Sec8_exocyst PF04048.14 ETO20362.1 - 0.025 14.5 2.6 0.032 14.1 1.2 1.8 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain DUF3584 PF12128.8 ETO20362.1 - 0.033 11.7 7.1 0.04 11.4 7.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Med9 PF07544.13 ETO20362.1 - 0.035 14.2 7.1 0.31 11.1 3.7 2.2 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 T2SSF PF00482.23 ETO20362.1 - 0.048 13.6 0.3 0.048 13.6 0.3 1.6 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F bZIP_1 PF00170.21 ETO20362.1 - 0.055 13.6 10.8 0.5 10.5 3.0 3.1 3 0 0 3 3 3 0 bZIP transcription factor DUF4200 PF13863.6 ETO20362.1 - 0.1 13.0 15.5 0.79 10.1 12.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Spc7 PF08317.11 ETO20362.1 - 0.12 11.3 11.4 0.17 10.8 11.4 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 ETO20362.1 - 0.17 12.2 7.4 9.6 6.6 0.0 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4618 PF15397.6 ETO20362.1 - 0.36 10.2 10.1 5.7 6.3 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) Exonuc_VII_L PF02601.15 ETO20362.1 - 0.41 10.2 3.3 0.48 9.9 3.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETO20362.1 - 0.6 10.2 8.3 3.2 7.8 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ETO20362.1 - 0.75 10.0 9.1 1.4 9.1 3.8 2.1 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family Wtap PF17098.5 ETO20362.1 - 1.6 8.6 10.7 3.7 7.4 6.6 2.1 2 0 0 2 2 2 0 WTAP/Mum2p family XhlA PF10779.9 ETO20362.1 - 1.7 8.9 9.0 0.6 10.4 5.0 2.2 2 1 1 3 3 3 0 Haemolysin XhlA DUF919 PF06034.11 ETO20362.1 - 1.9 8.4 10.0 1.5 8.7 5.2 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus protein of unknown function (DUF919) GAS PF13851.6 ETO20362.1 - 2 7.7 14.9 33 3.7 15.0 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4140 PF13600.6 ETO20362.1 - 2.2 8.8 5.8 38 4.8 0.0 2.5 2 1 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Jnk-SapK_ap_N PF09744.9 ETO20362.1 - 3.9 7.7 15.8 4.4 7.5 10.7 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TMCO5 PF14992.6 ETO20362.1 - 6.2 6.3 14.7 1.9 8.0 10.4 1.8 1 1 1 2 2 2 0 TMCO5 family TMPIT PF07851.13 ETO20362.1 - 6.3 6.0 9.6 0.59 9.3 1.8 2.0 1 1 1 2 2 2 0 TMPIT-like protein Atg14 PF10186.9 ETO20362.1 - 6.9 5.6 8.8 11 5.0 8.6 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Sporozoite_P67 PF05642.11 ETO20364.1 - 4.6 5.2 6.4 0.97 7.4 3.0 1.5 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Wyosine_form PF08608.12 ETO20365.1 - 7.7e-25 87.0 0.1 1.8e-24 85.9 0.1 1.6 1 0 0 1 1 1 1 Wyosine base formation Radical_SAM PF04055.21 ETO20365.1 - 7.5e-23 81.7 0.0 1.7e-22 80.6 0.0 1.7 1 0 0 1 1 1 1 Radical SAM superfamily Flavodoxin_1 PF00258.25 ETO20365.1 - 2.4e-17 63.5 1.8 4.3e-17 62.7 0.0 2.3 2 0 0 2 2 2 1 Flavodoxin CMD PF02627.20 ETO20365.1 - 0.26 11.4 0.6 2.1 8.4 0.3 2.5 2 0 0 2 2 2 0 Carboxymuconolactone decarboxylase family GREB1 PF15782.5 ETO20365.1 - 0.99 6.4 9.4 1.5 5.9 9.4 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF3391 PF11871.8 ETO20365.1 - 1.4 9.4 12.7 1.3 9.6 8.2 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3391) PH_12 PF16457.5 ETO20366.1 - 0.026 15.0 0.2 0.026 15.0 0.2 2.8 2 1 2 4 4 4 0 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO20366.1 - 0.031 14.4 0.2 0.031 14.4 0.2 2.3 3 0 0 3 3 3 0 Meiotic cell cortex C-terminal pleckstrin homology Ank_2 PF12796.7 ETO20367.1 - 5e-10 39.8 0.4 3.5e-05 24.3 0.1 2.8 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO20367.1 - 0.00011 22.6 0.3 0.24 12.0 0.1 3.1 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO20367.1 - 0.00048 20.4 0.3 0.29 11.5 0.0 3.2 3 1 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO20367.1 - 0.00078 19.7 1.8 2.2 9.1 0.0 4.8 6 0 0 6 6 6 1 Ankyrin repeat GBP_C PF02841.14 ETO20368.1 - 0.0007 19.1 2.6 0.00085 18.8 2.6 1.1 1 0 0 1 1 1 1 Guanylate-binding protein, C-terminal domain L27_2 PF09045.10 ETO20368.1 - 0.022 14.7 0.1 0.79 9.7 0.0 2.5 2 0 0 2 2 2 0 L27_2 GCFC PF07842.12 ETO20368.1 - 0.028 14.0 0.4 0.038 13.6 0.4 1.1 1 0 0 1 1 1 0 GC-rich sequence DNA-binding factor-like protein GLTSCR1 PF15249.6 ETO20368.1 - 0.093 13.2 3.7 0.14 12.6 3.7 1.3 1 1 0 1 1 1 0 Conserved region of unknown function on GLTSCR protein CbiC PF02570.15 ETO20368.1 - 0.14 11.8 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Precorrin-8X methylmutase ALMT PF11744.8 ETO20368.1 - 0.17 10.7 1.9 0.21 10.4 1.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter MAT1 PF06391.13 ETO20368.1 - 0.4 10.5 8.1 0.58 10.0 8.1 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Sec7 PF01369.20 ETO20370.1 - 2.9e-41 141.2 0.8 6.4e-41 140.0 0.8 1.6 1 0 0 1 1 1 1 Sec7 domain PH PF00169.29 ETO20370.1 - 0.0007 20.1 0.2 0.0033 17.9 0.0 2.2 2 0 0 2 2 2 1 PH domain DUF1435 PF07256.12 ETO20370.1 - 0.1 12.7 0.2 0.3 11.2 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1435) RRM_9 PF18444.1 ETO20371.1 - 0.0063 16.3 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif Cwf_Cwc_15 PF04889.12 ETO20371.1 - 0.25 11.0 17.9 0.057 13.1 10.9 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CSRNP_N PF16019.5 ETO20371.1 - 0.47 10.3 4.3 0.4 10.6 1.0 2.1 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus PRP1_N PF06424.12 ETO20371.1 - 1.2 9.5 12.6 0.94 9.9 7.1 2.5 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal Corazonin PF17308.2 ETO20371.1 - 3.3 8.1 22.6 1.5 9.2 2.9 2.7 3 0 0 3 3 3 0 Pro-corazonin Afi1 PF07792.12 ETO20371.1 - 3.3 8.2 15.6 2.4 8.7 8.7 2.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nop25 PF09805.9 ETO20371.1 - 6.7 7.2 13.0 3.4 8.1 6.7 3.0 3 0 0 3 3 3 0 Nucleolar protein 12 (25kDa) MFS_1 PF07690.16 ETO20372.1 - 2.1e-06 26.9 12.0 2.1e-06 26.9 12.0 2.4 2 1 0 2 2 2 2 Major Facilitator Superfamily CD34_antigen PF06365.12 ETO20372.1 - 0.3 10.7 0.2 0.49 10.0 0.2 1.3 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4383 PF14325.6 ETO20372.1 - 5.7 7.2 12.7 0.21 11.8 2.7 3.1 2 2 1 3 3 3 0 Domain of unknown function (DUF4383) Aminotran_1_2 PF00155.21 ETO20373.1 - 1.1e-20 74.2 0.0 1.3e-20 73.9 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II LacI PF00356.21 ETO20373.1 - 0.014 15.2 0.3 0.033 14.0 0.3 1.6 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family Myotub-related PF06602.14 ETO20374.1 - 1.6e-26 93.1 0.0 4.3e-26 91.7 0.0 1.7 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain C2 PF00168.30 ETO20374.1 - 8.7e-15 54.9 0.1 2.7e-14 53.3 0.1 1.9 1 0 0 1 1 1 1 C2 domain C9orf72-like PF15019.6 ETO20375.1 - 2.7e-24 86.1 4.0 2.1e-22 79.9 0.3 2.7 3 0 0 3 3 3 2 C9orf72-like protein family FAM176 PF14851.6 ETO20375.1 - 3.8 7.2 8.9 0.99 9.1 3.0 2.6 2 0 0 2 2 2 0 FAM176 family XAP5 PF04921.14 ETO20377.1 - 0.0017 18.2 9.1 0.0023 17.8 9.1 1.1 1 0 0 1 1 1 1 XAP5, circadian clock regulator zf-RanBP PF00641.18 ETO20377.1 - 0.003 16.9 0.6 0.003 16.9 0.6 1.9 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others DZR PF12773.7 ETO20377.1 - 0.072 13.1 0.3 0.16 12.1 0.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon Cript PF10235.9 ETO20377.1 - 0.093 13.3 0.3 0.093 13.3 0.3 2.4 2 0 0 2 2 2 0 Microtubule-associated protein CRIPT CDC45 PF02724.14 ETO20377.1 - 0.2 9.9 8.4 0.22 9.8 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Ephrin_rec_like PF07699.13 ETO20377.1 - 3.1 7.6 7.2 0.1 12.4 1.0 1.7 2 0 0 2 2 2 0 Putative ephrin-receptor like Zip PF02535.22 ETO20377.1 - 3.1 6.9 4.4 3.4 6.8 4.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO20377.1 - 4 6.1 7.7 4.5 5.9 7.7 1.1 1 0 0 1 1 1 0 Presenilin zf-C2H2_6 PF13912.6 ETO20378.1 - 0.00058 19.8 1.3 0.00058 19.8 1.3 2.4 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO20378.1 - 0.0025 18.2 1.0 0.0025 18.2 1.0 2.4 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-BED PF02892.15 ETO20378.1 - 0.02 14.9 8.6 0.098 12.7 2.7 2.6 2 0 0 2 2 2 0 BED zinc finger zf-H2C2_2 PF13465.6 ETO20378.1 - 2.6 8.6 15.5 0.64 10.5 2.8 3.0 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO20378.1 - 3.2 8.8 6.6 0.66 11.0 0.7 2.5 2 0 0 2 2 2 0 C2H2-type zinc finger RSN1_TM PF13967.6 ETO20379.1 - 0.00088 19.1 1.8 0.002 17.9 0.8 1.9 1 1 1 2 2 2 1 Late exocytosis, associated with Golgi transport OATP PF03137.20 ETO20379.1 - 0.0044 15.4 2.8 0.0059 14.9 2.8 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family tRNA_anti-like PF12869.7 ETO20379.1 - 0.011 15.3 0.3 0.021 14.4 0.3 1.5 1 0 0 1 1 1 0 tRNA_anti-like MMM1 PF10296.9 ETO20379.1 - 0.019 14.0 2.2 0.028 13.5 2.2 1.1 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 DUF3139 PF11337.8 ETO20379.1 - 0.021 15.5 1.6 0.048 14.3 1.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF4834 PF16118.5 ETO20379.1 - 0.038 15.0 1.4 0.074 14.0 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) BatD PF13584.6 ETO20379.1 - 0.049 12.5 0.1 0.063 12.1 0.1 1.3 1 0 0 1 1 1 0 Oxygen tolerance MscS_TM PF12794.7 ETO20379.1 - 1.7 7.4 4.7 4.5 6.0 0.1 2.1 1 1 0 2 2 2 0 Mechanosensitive ion channel inner membrane domain 1 Peptidase_S49_N PF08496.10 ETO20379.1 - 2.4 8.2 10.0 0.42 10.7 5.9 1.7 2 0 0 2 2 2 0 Peptidase family S49 N-terminal GATase PF00117.28 ETO20380.1 - 2.3e-09 37.3 0.0 4e-09 36.5 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO20380.1 - 0.00031 20.6 0.0 0.00057 19.7 0.0 1.4 1 0 0 1 1 1 1 Peptidase C26 DJ-1_PfpI PF01965.24 ETO20380.1 - 0.029 14.2 0.0 0.047 13.5 0.0 1.3 1 0 0 1 1 1 0 DJ-1/PfpI family GATase_3 PF07685.14 ETO20380.1 - 0.12 12.0 0.1 0.24 11.0 0.0 1.6 2 0 0 2 2 2 0 CobB/CobQ-like glutamine amidotransferase domain DUF1091 PF06477.13 ETO20381.1 - 0.01 16.3 0.3 0.02 15.4 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1091) LCIB_C_CA PF18599.1 ETO20381.1 - 0.45 9.8 2.9 2.7 7.2 0.3 2.1 2 0 0 2 2 2 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases Auxin_canalis PF05703.11 ETO20381.1 - 0.74 9.7 5.9 0.92 9.4 5.4 1.5 1 1 0 1 1 1 0 Auxin canalisation SR-25 PF10500.9 ETO20381.1 - 6.7 6.3 17.8 4.6 6.8 0.7 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein VPS9 PF02204.18 ETO20382.1 - 1.1e-08 35.2 0.0 1.8e-06 28.1 0.0 2.5 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain FSIP1 PF15554.6 ETO20382.1 - 0.036 13.2 0.0 0.054 12.6 0.0 1.2 1 0 0 1 1 1 0 FSIP1 family YMF19 PF02326.15 ETO20382.1 - 0.086 13.6 12.9 0.84 10.5 1.7 2.9 3 0 0 3 3 3 0 Plant ATP synthase F0 Glyco_hydro_35 PF01301.19 ETO20383.1 - 4.3e-27 95.6 0.0 5.6e-27 95.2 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 35 Ras PF00071.22 ETO20385.1 - 8.6e-17 61.2 0.1 2.6e-08 33.7 0.0 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO20385.1 - 0.0024 18.1 0.1 0.11 12.8 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase CENP-S PF15630.6 ETO20386.1 - 6.1e-13 49.0 1.0 1.7e-12 47.5 0.2 2.0 2 0 0 2 2 2 1 CENP-S protein CENP-T_C PF15511.6 ETO20386.1 - 0.0097 16.0 0.1 0.017 15.2 0.1 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TFIID_20kDa PF03847.13 ETO20386.1 - 0.12 12.9 1.9 1.7 9.2 1.9 2.4 1 1 0 1 1 1 0 Transcription initiation factor TFIID subunit A DUF3504 PF12012.8 ETO20386.1 - 2.3 8.1 5.1 1.6 8.6 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) Solute_trans_a PF03619.16 ETO20387.1 - 6.9e-36 124.1 17.3 8.4e-36 123.9 17.3 1.0 1 0 0 1 1 1 1 Organic solute transporter Ostalpha Solute_trans_a PF03619.16 ETO20388.1 - 4e-24 85.6 8.0 1e-23 84.2 7.8 1.7 2 0 0 2 2 2 1 Organic solute transporter Ostalpha IMD PF08397.11 ETO20388.1 - 0.045 13.1 0.3 0.097 12.0 0.3 1.5 1 0 0 1 1 1 0 IRSp53/MIM homology domain DNA_pol_D_N PF18018.1 ETO20390.1 - 0.2 11.8 3.1 0.49 10.5 3.1 1.5 1 1 0 1 1 1 0 DNA polymerase delta subunit OB-fold domain CytadhesinP1 PF12378.8 ETO20390.1 - 4.1 7.6 8.6 1.2 9.4 0.4 2.5 2 0 0 2 2 2 0 Trypsin-sensitive surface-exposed protein TRIQK PF15168.6 ETO20390.1 - 5.3 7.0 6.3 21 5.1 0.7 2.4 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family CAC1F_C PF16885.5 ETO20391.1 - 6.9 6.2 10.0 7.8 6.0 10.0 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Clathrin-link PF09268.10 ETO20392.1 - 0.018 14.4 0.1 0.041 13.3 0.1 1.6 1 0 0 1 1 1 0 Clathrin, heavy-chain linker FRG1 PF06229.12 ETO20393.1 - 1.1 9.0 4.4 0.82 9.3 2.7 1.6 2 0 0 2 2 2 0 FRG1-like domain Somatostatin PF03002.15 ETO20393.1 - 4.5 7.3 9.7 5.8 6.9 0.6 2.7 2 0 0 2 2 2 0 Somatostatin/Cortistatin family DUF2357 PF09823.9 ETO20394.1 - 0.12 11.6 2.0 0.13 11.5 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2357) EC042_2821 PF18740.1 ETO20394.1 - 0.25 11.2 0.1 0.25 11.2 0.1 2.7 3 0 0 3 3 3 0 EC042_2821-lke REase AMP-binding PF00501.28 ETO20395.1 - 3.1e-41 141.4 0.0 4.5e-41 140.8 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO20395.1 - 0.00062 20.7 0.0 0.0012 19.8 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 ETO20396.1 - 2.2e-07 29.9 0.0 3.8e-07 29.0 0.0 1.4 2 0 0 2 2 2 1 AMP-binding enzyme VWA_2 PF13519.6 ETO20397.1 - 0.0018 18.9 0.1 0.0076 16.9 0.1 2.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ETO20397.1 - 0.0035 16.8 0.0 0.79 9.1 0.0 2.4 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein VWA_3 PF13768.6 ETO20397.1 - 0.012 15.5 0.4 5.2 7.0 0.1 2.7 2 1 0 2 2 2 0 von Willebrand factor type A domain SRP54 PF00448.22 ETO20397.1 - 0.069 12.8 0.5 0.25 10.9 0.5 2.0 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Claudin_2 PF13903.6 ETO20399.1 - 0.0018 18.1 0.3 0.003 17.3 0.3 1.3 1 1 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Crystall_2 PF09076.10 ETO20399.1 - 0.0044 16.9 1.7 0.0085 16.0 1.6 1.6 1 1 0 1 1 1 1 Beta/Gamma crystallin Herpes_UL21 PF03252.13 ETO20399.1 - 0.15 10.8 0.2 0.17 10.6 0.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL21 OATP PF03137.20 ETO20399.1 - 0.16 10.2 5.1 1.4 7.1 0.1 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF3899 PF13038.6 ETO20399.1 - 0.72 10.4 10.6 0.084 13.4 2.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) Methyltransf_12 PF08242.12 ETO20399.1 - 0.93 10.3 2.8 3.1 8.6 0.0 2.4 2 1 0 2 2 2 0 Methyltransferase domain PUF PF00806.19 ETO20400.1 - 2.6e-19 67.7 3.6 0.00016 21.1 0.0 6.1 6 0 0 6 6 6 4 Pumilio-family RNA binding repeat DUF1387 PF07139.11 ETO20400.1 - 0.088 12.5 7.9 0.16 11.7 7.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Spore_YtfJ PF09579.10 ETO20400.1 - 0.2 11.8 5.8 0.46 10.7 5.8 1.6 1 0 0 1 1 1 0 Sporulation protein YtfJ (Spore_YtfJ) Baculo_11_kDa PF06143.11 ETO20400.1 - 0.36 10.4 3.1 4.8 6.8 0.1 2.8 2 0 0 2 2 2 0 Baculovirus 11 kDa family RCDG1 PF15725.5 ETO20400.1 - 0.37 11.2 3.0 1.3 9.5 3.0 2.0 1 0 0 1 1 1 0 Renal cancer differentiation gene 1 protein DUF1754 PF08555.10 ETO20400.1 - 1.5 9.7 12.8 3.3 8.6 12.8 1.6 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) CUB_2 PF02408.20 ETO20400.1 - 1.8 8.4 7.3 0.2 11.4 2.1 2.1 2 0 0 2 2 2 0 CUB-like domain SART-1 PF03343.13 ETO20400.1 - 2.7 6.4 6.5 3.5 6.1 6.5 1.1 1 0 0 1 1 1 0 SART-1 family PCNA_N PF00705.18 ETO20401.1 - 2e-39 134.2 0.9 5e-39 132.9 0.9 1.6 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain PCNA_C PF02747.15 ETO20401.1 - 3.4e-34 117.8 1.9 6.3e-18 65.2 0.1 3.0 2 1 1 3 3 3 2 Proliferating cell nuclear antigen, C-terminal domain Rad1 PF02144.16 ETO20401.1 - 1.8e-07 30.5 3.8 2.2e-05 23.7 3.8 2.3 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 ETO20401.1 - 7.4e-05 22.3 2.7 8.4e-05 22.1 1.4 1.7 1 1 1 2 2 2 1 Rad9 PH PF00169.29 ETO20402.1 - 7e-06 26.5 0.1 1.3e-05 25.6 0.1 1.5 1 0 0 1 1 1 1 PH domain Med13_C PF06333.12 ETO20402.1 - 0.055 12.7 0.1 0.072 12.3 0.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain PH_11 PF15413.6 ETO20402.1 - 0.075 13.5 0.1 0.2 12.1 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3439 PF11921.8 ETO20402.1 - 0.4 10.7 3.0 0.73 9.8 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) RabGAP-TBC PF00566.18 ETO20403.1 - 6.8e-13 48.8 0.1 8.1e-13 48.5 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain LMBR1 PF04791.16 ETO20403.1 - 0.02 13.8 0.3 0.024 13.6 0.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF226 PF02890.14 ETO20403.1 - 0.064 13.3 0.1 0.081 12.9 0.1 1.2 1 0 0 1 1 1 0 Borrelia family of unknown function DUF226 RXT2_N PF08595.11 ETO20404.1 - 0.013 15.5 3.1 0.021 14.8 3.1 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal DUF4611 PF15387.6 ETO20404.1 - 0.086 13.1 5.7 0.15 12.3 5.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 ETO20404.1 - 0.17 9.9 5.5 0.25 9.4 5.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SLAIN PF15301.6 ETO20404.1 - 0.43 9.8 3.4 1.1 8.4 3.4 1.7 1 1 0 1 1 1 0 SLAIN motif-containing family NOA36 PF06524.12 ETO20404.1 - 0.67 9.2 11.5 1 8.6 11.5 1.2 1 0 0 1 1 1 0 NOA36 protein CENP-B_dimeris PF09026.10 ETO20404.1 - 2.4 8.6 15.4 4.7 7.7 15.4 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO20404.1 - 6.8 4.7 9.1 10 4.1 9.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi PBP1_TM PF14812.6 ETO20404.1 - 6.9 7.1 11.0 13 6.2 11.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 ETO20404.1 - 9.3 5.9 11.4 13 5.4 11.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SNARE PF05739.19 ETO20406.1 - 2.5e-12 46.6 0.9 5.3e-12 45.5 0.9 1.6 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 ETO20406.1 - 0.00094 18.9 7.5 0.00094 18.9 7.5 1.8 2 0 0 2 2 2 1 Syntaxin DUF5345 PF17280.2 ETO20406.1 - 0.014 15.3 1.6 0.16 12.0 0.1 2.9 3 0 0 3 3 3 0 Family of unknown function (DUF5345) Med9 PF07544.13 ETO20406.1 - 1.6 8.9 6.5 0.39 10.8 0.6 2.8 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 zf-RanBP PF00641.18 ETO20409.1 - 2.1e-07 30.1 3.1 4.2e-07 29.2 3.1 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO20409.1 - 0.00047 19.5 4.0 0.0023 17.3 4.0 2.2 1 1 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain DZR PF12773.7 ETO20409.1 - 0.0062 16.5 0.3 0.015 15.3 0.3 1.6 1 0 0 1 1 1 1 Double zinc ribbon Tim54 PF11711.8 ETO20409.1 - 0.11 11.2 1.2 0.15 10.8 1.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HNF-1_N PF04814.13 ETO20409.1 - 0.83 10.2 4.3 1.2 9.8 4.3 1.2 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus CLPTM1 PF05602.12 ETO20410.1 - 0.038 13.0 0.4 0.046 12.7 0.4 1.2 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) WD40 PF00400.32 ETO20411.1 - 1.3e-32 111.2 8.7 1.2e-09 38.6 0.2 4.2 4 0 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO20411.1 - 3.6e-09 36.0 0.6 0.024 13.6 0.0 3.9 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO20411.1 - 7e-09 35.9 0.6 0.0044 17.3 0.1 3.5 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO20411.1 - 3.1e-05 23.8 6.8 0.49 10.4 0.4 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO20411.1 - 0.00024 19.8 0.7 0.58 8.6 0.1 2.9 2 1 1 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO20411.1 - 0.0093 14.7 5.5 1.4 7.5 1.0 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 VID27 PF08553.10 ETO20411.1 - 0.022 13.8 0.1 0.031 13.4 0.1 1.4 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain Utp8 PF10395.9 ETO20411.1 - 0.024 13.2 0.3 0.37 9.2 0.1 2.1 2 0 0 2 2 2 0 Utp8 family WD40_like PF17005.5 ETO20411.1 - 0.025 13.9 1.7 6.8 5.9 0.1 2.7 2 1 0 3 3 3 0 WD40-like domain Ubiquitin_3 PF14836.6 ETO20411.1 - 0.091 12.8 0.3 21 5.2 0.0 3.1 2 1 1 3 3 3 0 Ubiquitin-like domain Kelch_1 PF01344.25 ETO20412.1 - 0.00015 21.2 2.4 0.54 9.9 0.1 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO20412.1 - 0.01 15.9 1.3 1.1 9.3 0.0 3.8 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO20412.1 - 0.02 15.2 3.7 0.39 11.1 0.1 3.9 5 0 0 5 5 5 0 Kelch motif Kelch_5 PF13854.6 ETO20412.1 - 0.54 10.3 3.2 58 3.8 0.0 3.9 5 0 0 5 5 5 0 Kelch motif Peptidase_M3 PF01432.20 ETO20413.1 - 2.9e-36 125.7 0.7 2.1e-20 73.5 2.6 2.3 2 0 0 2 2 2 2 Peptidase family M3 VWA PF00092.28 ETO20414.1 - 0.00028 21.2 0.0 0.00046 20.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Menin PF05053.13 ETO20416.1 - 0.1 10.9 4.0 0.12 10.7 4.0 1.1 1 0 0 1 1 1 0 Menin DUF4692 PF15763.5 ETO20416.1 - 0.62 10.5 3.8 0.89 10.0 3.8 1.2 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) LRRFIP PF09738.9 ETO20417.1 - 0.05 13.1 0.5 0.065 12.7 0.5 1.2 1 0 0 1 1 1 0 LRRFIP family HAUS2 PF15003.6 ETO20417.1 - 0.062 13.0 0.2 0.16 11.7 0.1 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 2 WD40 PF00400.32 ETO20418.1 - 1.3e-55 184.1 21.0 6.1e-11 42.7 0.4 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20418.1 - 1.6e-20 73.2 1.2 0.00014 22.1 0.0 6.1 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20418.1 - 1.8e-12 46.9 2.4 0.042 12.8 0.0 6.4 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO20418.1 - 9.9e-08 31.6 1.8 0.016 14.5 0.1 3.4 3 0 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO20418.1 - 3.6e-07 29.2 6.2 0.0057 15.4 0.8 4.1 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO20418.1 - 1.4e-05 24.9 1.6 0.67 10.0 0.1 4.2 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO20418.1 - 0.0048 15.5 0.2 2.7 6.4 0.0 3.3 1 1 1 4 4 4 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO20418.1 - 0.011 15.6 0.0 54 4.0 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat DUF285 PF03382.14 ETO20418.1 - 0.022 14.5 1.1 0.41 10.4 0.0 3.0 2 2 1 3 3 3 0 Mycoplasma protein of unknown function, DUF285 DUF727 PF05303.12 ETO20418.1 - 0.047 13.8 0.1 5.2 7.2 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF727) DPPIV_N PF00930.21 ETO20418.1 - 0.058 12.1 0.1 12 4.5 0.0 3.4 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Coatomer_WDAD PF04053.14 ETO20418.1 - 0.059 12.4 1.3 4.8 6.1 0.2 2.3 1 1 0 2 2 2 0 Coatomer WD associated region DUF2963 PF11178.8 ETO20418.1 - 0.16 11.7 0.2 5.3 6.8 0.0 3.1 2 1 0 2 2 2 0 Protein of unknown function (DUF2963) Proteasome_A_N PF10584.9 ETO20418.1 - 0.64 9.7 1.7 45 3.9 0.0 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO20419.1 - 1.1e-09 38.2 2.3 0.0037 17.5 0.0 4.3 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO20419.1 - 9.1e-09 34.8 3.3 0.013 15.1 0.3 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ETO20419.1 - 4e-08 33.1 1.6 0.12 12.4 0.2 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO20419.1 - 9.8e-07 28.5 4.3 0.24 11.4 0.1 5.4 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO20419.1 - 1.1e-05 25.6 0.5 0.0059 16.9 0.0 4.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO20419.1 - 0.0027 17.7 4.0 5.4 7.1 0.0 4.7 5 0 0 5 5 5 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO20419.1 - 0.011 14.9 0.0 3.7 6.6 0.0 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Ntox33 PF15533.6 ETO20419.1 - 0.054 14.0 0.4 0.19 12.2 0.4 1.9 1 0 0 1 1 1 0 Bacterial toxin 33 WD40 PF00400.32 ETO20420.1 - 9.4e-59 194.0 11.5 2.2e-10 41.0 0.2 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20420.1 - 5.4e-22 77.9 2.8 0.0024 18.1 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20420.1 - 3.4e-15 55.8 1.3 0.0023 16.9 0.0 5.8 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO20420.1 - 8.6e-11 41.2 5.6 0.34 9.5 0.1 5.9 1 1 4 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO20420.1 - 5.3e-09 35.8 6.6 0.00011 21.6 0.0 3.8 1 1 2 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO20420.1 - 2.7e-05 24.0 0.2 3.8 7.6 0.0 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO20420.1 - 0.00023 20.6 1.1 3.5 6.9 0.0 3.6 1 1 2 3 3 3 3 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO20420.1 - 0.00026 19.6 1.9 1.8 7.0 0.0 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO20420.1 - 0.028 13.2 0.2 1.4 7.6 0.0 2.9 1 1 1 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF285 PF03382.14 ETO20420.1 - 0.15 11.8 2.7 2 8.2 0.2 3.6 1 1 3 4 4 4 0 Mycoplasma protein of unknown function, DUF285 Proteasome_A_N PF10584.9 ETO20420.1 - 0.76 9.5 5.4 16 5.3 0.2 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO20421.1 - 7e-49 162.8 11.0 1.7e-08 34.9 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20421.1 - 5.6e-16 58.6 4.1 0.00033 20.9 0.0 7.1 3 1 5 8 8 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20421.1 - 2e-09 36.9 0.1 3.7 6.4 0.0 6.0 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO20421.1 - 1.1e-05 24.3 3.8 0.42 9.2 0.1 4.6 2 1 3 5 5 5 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO20421.1 - 0.00013 22.0 0.5 7.7 6.6 0.1 4.3 1 1 4 5 5 5 2 Family of unknown function (DUF5570) Kelch_6 PF13964.6 ETO20421.1 - 0.00022 21.4 0.1 0.0018 18.5 0.0 2.7 2 0 0 2 2 2 1 Kelch motif PQQ_2 PF13360.6 ETO20421.1 - 0.0021 17.7 0.1 0.22 11.1 0.0 2.3 2 0 0 2 2 2 1 PQQ-like domain Kelch_4 PF13418.6 ETO20421.1 - 0.0086 16.1 0.0 0.045 13.8 0.0 2.3 2 0 0 2 2 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO20421.1 - 0.035 14.1 0.0 0.21 11.6 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO20421.1 - 0.072 13.4 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO20421.1 - 0.082 12.9 0.5 0.18 11.8 0.2 1.8 2 0 0 2 2 1 0 Kelch motif B_lectin PF01453.24 ETO20421.1 - 0.14 12.8 0.8 1 9.9 0.3 2.5 2 1 0 2 2 2 0 D-mannose binding lectin TFB6 PF17110.5 ETO20422.1 - 3.4 7.4 8.5 1.2 8.9 5.5 1.8 1 1 1 2 2 2 0 Subunit 11 of the general transcription factor TFIIH DUF4254 PF14063.6 ETO20425.1 - 0.0014 18.5 2.7 0.0033 17.2 2.9 1.5 1 1 1 2 2 2 1 Protein of unknown function (DUF4254) RGS PF00615.19 ETO20426.1 - 0.00075 19.8 0.3 0.00097 19.4 0.3 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain CRS1_YhbY PF01985.21 ETO20426.1 - 0.16 12.2 0.5 0.27 11.4 0.5 1.4 1 1 0 1 1 1 0 CRS1 / YhbY (CRM) domain TMEM247 PF15444.6 ETO20427.1 - 0.28 11.2 5.0 0.15 12.1 1.5 2.2 1 1 1 2 2 2 0 Transmembrane protein 247 Plasmodium_Vir PF05795.11 ETO20428.1 - 0.086 12.2 13.5 0.096 12.1 13.5 1.0 1 0 0 1 1 1 0 Plasmodium vivax Vir protein Mitofilin PF09731.9 ETO20428.1 - 0.19 10.5 15.1 0.22 10.3 15.1 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein FAM60A PF15396.6 ETO20428.1 - 0.56 10.2 11.1 0.7 9.9 11.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A DUF908 PF06012.12 ETO20428.1 - 1 8.7 12.3 1.2 8.5 12.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Suf PF05843.14 ETO20428.1 - 1.9 8.4 11.2 2.1 8.3 11.2 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2052 PF09747.9 ETO20428.1 - 1.9 8.6 10.8 2.3 8.3 10.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) KCNQ2_u3 PF16642.5 ETO20428.1 - 4.7 8.3 9.0 5 8.2 7.8 1.6 1 1 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 LAP1C PF05609.12 ETO20428.1 - 5.7 5.9 16.1 6.2 5.8 16.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BTB PF00651.31 ETO20429.1 - 6.8e-12 45.6 0.5 7.6e-11 42.2 0.1 2.1 1 1 1 2 2 2 1 BTB/POZ domain BACK PF07707.15 ETO20429.1 - 0.0049 16.9 0.2 0.019 15.1 0.0 2.1 2 1 0 2 2 2 1 BTB And C-terminal Kelch Skp1_POZ PF03931.15 ETO20429.1 - 0.19 11.9 1.6 1.2 9.4 0.1 2.8 2 2 1 3 3 3 0 Skp1 family, tetramerisation domain AAA PF00004.29 ETO20430.1 - 6.4e-09 36.3 2.9 0.00063 20.2 0.0 3.3 3 0 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO20430.1 - 4.6e-08 32.7 0.0 9.8e-08 31.7 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ETO20430.1 - 5.7e-05 23.0 0.0 0.00014 21.8 0.0 1.7 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain Mg_chelatase PF01078.21 ETO20430.1 - 0.02 14.3 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETO20430.1 - 0.06 13.3 0.0 1.9 8.5 0.0 2.7 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF1765 PF08578.10 ETO20431.1 - 4e-14 53.2 2.6 4e-14 53.2 2.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF1765) MRP-S23 PF10484.9 ETO20433.1 - 0.033 14.5 0.8 0.11 12.7 0.3 2.1 2 0 0 2 2 2 0 Mitochondrial ribosomal protein S23 C8 PF08742.11 ETO20434.1 - 0.26 11.7 9.5 0.3 11.5 5.8 2.3 2 0 0 2 2 2 0 C8 domain PBP1_TM PF14812.6 ETO20435.1 - 0.061 13.7 0.2 0.061 13.7 0.2 1.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal UNC80 PF15778.5 ETO20435.1 - 0.13 11.8 0.5 0.18 11.4 0.5 1.3 1 1 0 1 1 1 0 Cation channel complex component UNC80 Orf78 PF06024.12 ETO20435.1 - 0.25 11.6 1.4 0.58 10.5 1.4 1.8 1 1 0 1 1 1 0 Orf78 (ac78) Myc_N PF01056.18 ETO20435.1 - 0.29 11.0 4.8 0.34 10.8 4.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Rep_1 PF01446.17 ETO20435.1 - 0.31 10.5 2.3 0.35 10.3 2.3 1.1 1 0 0 1 1 1 0 Replication protein AIM3 PF17096.5 ETO20435.1 - 0.55 11.2 4.4 0.1 13.5 1.1 1.5 2 0 0 2 2 2 0 Altered inheritance of mitochondria protein 3 Calcipressin PF04847.12 ETO20435.1 - 0.82 9.4 4.2 1 9.0 4.1 1.3 1 1 0 1 1 1 0 Calcipressin BSP_II PF05432.11 ETO20435.1 - 0.88 9.2 14.4 1.1 8.9 14.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NOA36 PF06524.12 ETO20435.1 - 9.7 5.4 9.0 11 5.2 9.0 1.2 1 0 0 1 1 1 0 NOA36 protein PRKG1_interact PF15898.5 ETO20436.1 - 0.017 16.0 9.1 0.017 16.0 9.1 3.6 1 1 3 4 4 4 0 cGMP-dependent protein kinase interacting domain DDE_Tnp_ISL3 PF01610.17 ETO20436.1 - 0.072 12.8 11.6 0.057 13.1 0.9 2.5 2 1 0 2 2 2 0 Transposase YabA PF06156.13 ETO20436.1 - 0.13 12.9 28.1 0.088 13.4 2.3 3.8 2 2 2 4 4 4 0 Initiation control protein YabA DUF4407 PF14362.6 ETO20436.1 - 0.2 11.0 16.2 4.5e+02 -0.0 16.2 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) TSC22 PF01166.18 ETO20436.1 - 0.53 10.6 19.7 1.1 9.6 0.3 4.2 4 0 0 4 4 4 0 TSC-22/dip/bun family HALZ PF02183.18 ETO20436.1 - 1.3 9.3 19.1 1.2 9.4 1.6 4.1 4 0 0 4 4 4 0 Homeobox associated leucine zipper YnfE PF17452.2 ETO20436.1 - 1.4 9.2 4.4 1.9 8.9 0.1 2.9 2 1 1 3 3 3 0 Uncharacterized YnfE-like Baculo_PEP_C PF04513.12 ETO20436.1 - 1.8 8.6 9.8 0.5 10.4 1.7 3.1 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus DivIC PF04977.15 ETO20436.1 - 3.9 7.3 21.5 0.61 9.9 0.1 4.3 4 1 1 5 5 5 0 Septum formation initiator NPV_P10 PF05531.12 ETO20436.1 - 6.4 7.3 12.8 11 6.6 4.2 4.2 3 1 1 4 4 4 0 Nucleopolyhedrovirus P10 protein Xpo1 PF08389.12 ETO20437.1 - 0.0018 18.4 0.1 0.0034 17.4 0.1 1.5 1 0 0 1 1 1 1 Exportin 1-like protein DUF3342 PF11822.8 ETO20439.1 - 3 8.1 5.8 1 9.6 2.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3342) Xpo1 PF08389.12 ETO20440.1 - 0.016 15.3 6.2 1.8 8.6 0.2 3.2 2 1 0 2 2 2 0 Exportin 1-like protein TetR_C_8 PF14278.6 ETO20440.1 - 0.033 14.3 1.7 0.17 12.0 0.1 2.5 2 1 0 2 2 2 0 Transcriptional regulator C-terminal region Importin_rep_3 PF18806.1 ETO20440.1 - 0.37 10.9 2.6 0.97 9.5 0.0 2.9 3 0 0 3 3 3 0 Importin 13 repeat Pre-PUA PF17832.1 ETO20441.1 - 1.6e-20 73.5 0.1 2.6e-20 72.9 0.1 1.3 1 0 0 1 1 1 1 Pre-PUA-like domain PUA PF01472.20 ETO20441.1 - 1.3e-12 47.5 0.0 2e-12 46.9 0.0 1.4 1 0 0 1 1 1 1 PUA domain LRR_8 PF13855.6 ETO20442.1 - 4.8e-10 39.1 17.2 2.2e-07 30.5 4.7 4.6 4 1 1 5 5 5 2 Leucine rich repeat LRR_4 PF12799.7 ETO20442.1 - 0.0001 22.6 24.0 0.0042 17.5 3.2 4.8 3 1 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO20442.1 - 0.0044 17.4 14.1 1.4 9.8 0.2 6.0 5 0 0 5 5 5 1 Leucine Rich Repeat LRR_9 PF14580.6 ETO20442.1 - 0.15 11.5 3.0 0.32 10.5 2.1 1.9 1 1 0 1 1 1 0 Leucine-rich repeat DUF4010 PF13194.6 ETO20442.1 - 3.1 7.4 8.7 0.7 9.5 2.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4010) ASFV_J13L PF05568.11 ETO20442.1 - 5.1 6.8 4.6 8.6 6.1 2.8 2.3 1 1 0 1 1 1 0 African swine fever virus J13L protein Swi6_N PF18530.1 ETO20443.1 - 0.0077 16.4 0.5 0.93 9.7 0.2 3.4 2 0 0 2 2 2 2 Swi6 N-terminal domain Zip PF02535.22 ETO20444.1 - 0.11 11.7 1.7 0.21 10.7 1.7 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter POX PF07526.11 ETO20444.1 - 5.5 7.6 8.3 2.1 8.9 0.5 3.1 3 0 0 3 3 3 0 Associated with HOX Pkinase PF00069.25 ETO20445.1 - 2.1e-37 128.9 0.0 2.1e-37 128.9 0.0 1.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20445.1 - 7.1e-15 55.0 0.0 7.1e-15 55.0 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase BSP_II PF05432.11 ETO20445.1 - 0.023 14.4 9.1 0.033 13.9 9.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Seadorna_VP7 PF07387.11 ETO20445.1 - 0.05 12.7 0.0 0.088 11.8 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 RRN3 PF05327.11 ETO20445.1 - 0.29 9.6 3.8 0.33 9.4 3.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Myc_N PF01056.18 ETO20445.1 - 0.35 10.7 7.3 0.48 10.3 7.3 1.2 1 0 0 1 1 1 0 Myc amino-terminal region RNA_pol_3_Rpc31 PF11705.8 ETO20445.1 - 4 7.6 13.7 7.2 6.8 13.7 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 LMBR1 PF04791.16 ETO20446.1 - 0.0046 15.9 3.2 0.006 15.6 3.2 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein 2-oxoacid_dh PF00198.23 ETO20446.1 - 0.0096 15.4 0.8 0.016 14.7 0.8 1.3 1 0 0 1 1 1 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) DUF3464 PF11947.8 ETO20446.1 - 1.6 8.5 6.7 9.1 6.0 0.0 3.0 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 TPP_enzyme_N PF02776.18 ETO20447.1 - 6.7e-18 64.9 0.0 1e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 Thiamine pyrophosphate enzyme, N-terminal TPP binding domain DUF1754 PF08555.10 ETO20447.1 - 0.02 15.7 8.0 0.031 15.1 8.0 1.2 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) Kelch_5 PF13854.6 ETO20448.1 - 3.1e-06 27.0 7.2 0.39 10.8 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 ETO20448.1 - 0.0089 15.6 4.2 7.2 6.3 0.2 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO20448.1 - 0.019 14.9 2.8 2.4 8.3 0.1 4.3 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO20448.1 - 0.083 13.2 8.0 6.8 7.1 0.2 4.6 5 1 0 5 5 5 0 Kelch motif Kelch_4 PF13418.6 ETO20448.1 - 0.16 12.0 0.5 6.9 6.8 0.2 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain Myticin-prepro PF10690.9 ETO20448.1 - 1.1 9.6 4.3 2.7 8.3 0.5 2.4 1 1 1 2 2 2 0 Myticin pre-proprotein from the mussel ADIP PF11559.8 ETO20449.1 - 0.00031 20.9 6.8 0.0008 19.5 3.4 2.6 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding GyrB_insert PF18053.1 ETO20449.1 - 0.1 12.5 2.3 0.19 11.6 0.7 1.9 1 1 1 2 2 2 0 DNA gyrase B subunit insert domain ATG16 PF08614.11 ETO20449.1 - 0.24 11.6 6.3 0.57 10.4 6.4 1.7 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) V-set_CD47 PF08204.11 ETO20449.1 - 2.3 8.2 7.2 1.7 8.6 0.2 2.6 1 1 2 3 3 3 0 CD47 immunoglobulin-like domain SAM_1 PF00536.30 ETO20450.1 - 2e-14 53.8 0.1 3.5e-14 53.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO20450.1 - 2.8e-14 52.9 0.1 5.1e-14 52.1 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ETO20450.1 - 4.8e-06 26.5 0.1 9.8e-06 25.5 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO20450.1 - 0.027 14.4 0.0 0.055 13.4 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Tox-REase-2 PF15646.6 ETO20450.1 - 0.063 13.5 0.4 0.83 9.8 0.0 2.3 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 2 TFCD_C PF12612.8 ETO20451.1 - 0.011 15.5 0.3 3.3 7.5 0.0 2.4 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal DDT PF02791.17 ETO20451.1 - 0.093 13.1 0.3 0.58 10.5 0.0 2.4 2 0 0 2 2 2 0 DDT domain DUF1840 PF08895.11 ETO20451.1 - 0.37 11.1 3.0 12 6.2 0.4 3.4 3 1 0 3 3 3 0 Domain of unknown function (DUF1840) Sec20 PF03908.13 ETO20453.1 - 0.12 12.3 1.5 0.27 11.2 1.5 1.6 1 0 0 1 1 1 0 Sec20 CENP-H PF05837.12 ETO20455.1 - 0.0055 17.1 8.1 0.31 11.5 2.5 2.2 1 1 1 2 2 2 2 Centromere protein H (CENP-H) Apolipoprotein PF01442.18 ETO20455.1 - 0.0055 16.6 3.3 0.01 15.7 2.7 1.4 1 1 0 1 1 1 1 Apolipoprotein A1/A4/E domain AAA_13 PF13166.6 ETO20455.1 - 0.0064 15.2 7.3 0.0076 15.0 7.3 1.1 1 0 0 1 1 1 1 AAA domain TPR_MLP1_2 PF07926.12 ETO20455.1 - 0.008 16.2 9.1 0.051 13.6 0.2 2.2 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein DUF4455 PF14643.6 ETO20455.1 - 0.0086 14.8 8.2 0.011 14.5 8.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4455) CENP-F_leu_zip PF10473.9 ETO20455.1 - 0.021 14.9 14.5 0.12 12.3 15.0 1.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 K-box PF01486.17 ETO20455.1 - 0.021 15.0 8.6 0.045 13.9 8.6 1.6 1 1 0 1 1 1 0 K-box region DLP_helical PF18709.1 ETO20455.1 - 0.027 13.7 9.0 0.06 12.5 1.2 2.0 1 1 1 2 2 2 0 Dynamin-like helical domain FliD_N PF02465.18 ETO20455.1 - 0.028 15.1 11.0 0.61 10.8 3.9 2.6 1 1 2 3 3 3 0 Flagellar hook-associated protein 2 N-terminus UPF0242 PF06785.11 ETO20455.1 - 0.039 14.1 10.5 0.053 13.6 10.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PIG-P PF08510.12 ETO20455.1 - 0.052 13.5 0.2 0.095 12.6 0.2 1.4 1 0 0 1 1 1 0 PIG-P GIT_CC PF16559.5 ETO20455.1 - 0.08 12.8 3.0 0.12 12.2 0.2 2.3 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Phlebovirus_NSM PF07246.11 ETO20455.1 - 0.091 12.1 7.2 0.12 11.7 7.2 1.2 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M DUF4407 PF14362.6 ETO20455.1 - 0.12 11.7 3.8 0.15 11.3 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 ETO20455.1 - 0.15 10.6 8.2 0.22 10.1 8.2 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF1829 PF08862.10 ETO20455.1 - 0.17 12.4 6.3 1.3 9.6 3.2 2.2 1 1 1 2 2 2 0 Domain of unknown function DUF1829 Mt_ATP-synt_D PF05873.12 ETO20455.1 - 0.2 11.5 7.6 5.7 6.8 0.1 2.3 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) Jnk-SapK_ap_N PF09744.9 ETO20455.1 - 0.23 11.7 11.6 0.52 10.5 11.6 1.6 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 Exonuc_VII_L PF02601.15 ETO20455.1 - 0.24 10.9 3.6 0.28 10.7 3.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3552 PF12072.8 ETO20455.1 - 0.25 10.8 11.2 0.38 10.1 11.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF148 PF02520.17 ETO20455.1 - 0.29 11.3 10.1 5.6 7.1 6.8 2.4 1 1 1 2 2 2 0 Domain of unknown function DUF148 DUF2228 PF10228.9 ETO20455.1 - 0.29 10.8 7.1 3.6 7.2 3.5 2.2 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2228) PspA_IM30 PF04012.12 ETO20455.1 - 0.3 10.6 8.9 17 4.9 8.4 2.1 1 1 0 1 1 1 0 PspA/IM30 family Occludin_ELL PF07303.13 ETO20455.1 - 0.31 11.8 10.5 0.94 10.2 6.1 2.2 1 1 1 2 2 2 0 Occludin homology domain CdvA PF18822.1 ETO20455.1 - 0.34 10.8 10.2 23 4.8 9.9 2.4 1 1 0 1 1 1 0 CdvA-like coiled-coil domain Lipase_chap PF03280.14 ETO20455.1 - 0.34 10.8 5.0 0.5 10.3 3.0 2.1 1 1 1 2 2 2 0 Proteobacterial lipase chaperone protein Golgin_A5 PF09787.9 ETO20455.1 - 0.36 10.3 11.5 1.6 8.1 3.8 2.0 1 1 0 1 1 1 0 Golgin subfamily A member 5 UPF0449 PF15136.6 ETO20455.1 - 0.4 11.2 10.7 3.3 8.2 2.9 2.3 1 1 1 2 2 2 0 Uncharacterised protein family UPF0449 Sec34 PF04136.15 ETO20455.1 - 0.43 10.5 11.7 0.85 9.5 0.6 2.2 1 1 1 2 2 2 0 Sec34-like family MRP-S26 PF14943.6 ETO20455.1 - 0.44 10.5 9.5 1.1 9.1 9.5 1.6 1 1 0 1 1 1 0 Mitochondrial ribosome subunit S26 Baculo_PEP_C PF04513.12 ETO20455.1 - 0.46 10.5 8.0 1.2 9.2 6.7 2.0 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Helicase_IV_N PF12462.8 ETO20455.1 - 0.51 10.3 4.2 0.29 11.1 1.6 1.7 1 1 1 2 2 2 0 DNA helicase IV / RNA helicase N terminal V-ATPase_G PF03179.15 ETO20455.1 - 0.65 10.6 8.6 1.4 9.5 6.8 2.1 1 1 2 3 3 3 0 Vacuolar (H+)-ATPase G subunit DUF1664 PF07889.12 ETO20455.1 - 0.75 9.8 6.3 7.9 6.5 5.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Csm1_N PF18504.1 ETO20455.1 - 0.77 10.1 9.3 4.8 7.6 0.6 2.7 2 1 0 2 2 2 0 Csm1 N-terminal domain DUF2203 PF09969.9 ETO20455.1 - 1.1 10.0 4.4 3.6 8.3 4.2 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF3450 PF11932.8 ETO20455.1 - 1.2 8.4 11.1 0.57 9.4 5.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) NPV_P10 PF05531.12 ETO20455.1 - 1.3 9.5 12.7 5.4 7.6 7.2 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 ETO20455.1 - 2.2 7.4 10.8 4.3 6.5 9.1 1.9 1 1 1 2 2 2 0 TMPIT-like protein MerR-DNA-bind PF09278.11 ETO20455.1 - 2.8 8.6 5.6 1.4 9.5 0.6 2.7 2 1 1 3 3 2 0 MerR, DNA binding DivIC PF04977.15 ETO20455.1 - 2.8 7.8 11.8 3.5 7.5 0.5 2.8 1 1 2 3 3 3 0 Septum formation initiator YabA PF06156.13 ETO20455.1 - 3.1 8.5 9.6 6.4 7.5 2.3 2.4 1 1 1 2 2 2 0 Initiation control protein YabA CRR7 PF12095.8 ETO20455.1 - 5.7 7.5 7.5 12 6.4 1.8 2.5 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 LMBR1 PF04791.16 ETO20455.1 - 6.7 5.5 5.9 8.3 5.2 5.9 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein VPS11_C PF12451.8 ETO20455.1 - 7.2 6.9 5.8 21 5.5 0.9 3.1 3 1 1 4 4 3 0 Vacuolar protein sorting protein 11 C terminal ACCA PF03255.14 ETO20455.1 - 9.1 6.1 8.3 4.7 7.1 2.1 2.1 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Cu-oxidase_3 PF07732.15 ETO20456.1 - 8.2e-07 29.0 0.1 1.3e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 Multicopper oxidase WD40 PF00400.32 ETO20457.1 - 0.0017 19.1 1.0 0.5 11.3 0.1 3.0 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF4416 PF14385.6 ETO20458.1 - 0.04 13.8 3.1 0.43 10.5 0.8 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4416) BRE1 PF08647.11 ETO20458.1 - 6.3 7.0 15.6 25 5.1 3.0 3.3 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF2098 PF09871.9 ETO20458.1 - 6.9 7.1 10.0 2.2 8.7 5.0 2.7 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) APCDDC PF14921.6 ETO20460.1 - 0.012 15.1 1.2 0.014 14.8 1.2 1.1 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 ICMT PF04140.14 ETO20461.1 - 3.3e-28 97.9 1.7 8.3e-28 96.7 1.7 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO20461.1 - 3e-10 40.4 1.6 3e-10 40.4 1.6 2.4 3 0 0 3 3 3 1 Phospholipid methyltransferase DUF1295 PF06966.12 ETO20461.1 - 0.008 15.7 0.7 0.013 15.0 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) DUF3040 PF11239.8 ETO20461.1 - 0.14 12.5 0.4 16 5.8 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) DUF3671 PF12420.8 ETO20461.1 - 0.2 11.7 3.1 0.6 10.2 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function TMEM100 PF16311.5 ETO20461.1 - 1.1 8.9 4.3 3.4 7.3 0.2 3.1 3 1 0 3 3 3 0 Transmembrane protein 100 Pkinase PF00069.25 ETO20462.1 - 7.4e-21 74.7 0.0 2.7e-20 72.8 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20462.1 - 1.1e-05 24.8 0.0 0.00074 18.9 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase PH_8 PF15409.6 ETO20462.1 - 0.19 12.0 3.6 0.36 11.1 3.6 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain Pkinase PF00069.25 ETO20463.1 - 1.2e-08 34.7 0.0 1.5e-08 34.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain cNMP_binding PF00027.29 ETO20464.1 - 1.3e-17 63.6 0.0 2.6e-17 62.7 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain zf-TRAF PF02176.18 ETO20465.1 - 1.4e-06 28.9 10.0 5.8e-06 26.9 4.6 3.1 2 0 0 2 2 2 1 TRAF-type zinc finger DUF3342 PF11822.8 ETO20465.1 - 0.038 14.2 1.1 0.17 12.1 1.0 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Cys_rich_KTR PF14205.6 ETO20465.1 - 0.049 13.4 0.7 0.2 11.5 0.2 2.2 2 0 0 2 2 2 0 Cysteine-rich KTR zf-AD PF07776.15 ETO20465.1 - 0.11 12.7 0.5 0.11 12.7 0.5 3.0 4 0 0 4 4 4 0 Zinc-finger associated domain (zf-AD) Macoilin PF09726.9 ETO20468.1 - 9.8 4.6 44.4 12 4.3 44.4 1.0 1 0 0 1 1 1 0 Macoilin family Nop14 PF04147.12 ETO20469.1 - 0.011 14.1 19.6 0.01 14.1 19.6 1.0 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO20469.1 - 0.97 8.1 10.2 1 8.0 10.2 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO20469.1 - 1.9 7.5 8.0 2.1 7.3 8.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 ETO20469.1 - 4.6 5.9 18.1 5 5.8 18.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RR_TM4-6 PF06459.12 ETO20469.1 - 5.8 6.7 11.8 7.6 6.3 11.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO20469.1 - 6.8 5.8 10.0 7.1 5.7 10.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 ETO20469.1 - 7.2 5.3 15.3 8.2 5.1 15.3 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein MDM10 PF12519.8 ETO20469.1 - 7.7 5.3 6.1 6.9 5.4 6.1 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CAP_C PF08603.11 ETO20470.1 - 2.3e-08 33.8 4.0 4.1e-08 33.0 4.0 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ETO20470.1 - 4e-07 29.8 10.0 1.1e-06 28.3 10.0 1.8 1 0 0 1 1 1 1 Tubulin binding cofactor C YEATS PF03366.16 ETO20470.1 - 0.0016 18.4 0.1 0.0088 16.0 0.0 2.3 2 1 0 2 2 2 1 YEATS family Kelch_5 PF13854.6 ETO20471.1 - 0.044 13.8 2.2 6.9 6.8 0.1 3.6 4 0 0 4 4 4 0 Kelch motif DUF2272 PF10030.9 ETO20471.1 - 0.13 12.0 0.0 0.22 11.3 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) IQ PF00612.27 ETO20472.1 - 0.00062 19.3 5.6 0.0039 16.8 0.0 4.0 4 0 0 4 4 4 1 IQ calmodulin-binding motif DUF4579 PF15158.6 ETO20472.1 - 0.023 14.5 6.4 0.029 14.1 5.5 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4579) DUF4230 PF14014.6 ETO20472.1 - 0.2 11.9 4.1 0.32 11.2 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4230) EMC3_TMCO1 PF01956.16 ETO20472.1 - 2.9 7.6 12.1 0.48 10.1 7.4 1.9 1 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like G-alpha PF00503.20 ETO20473.1 - 5.5e-13 48.8 6.9 6.8e-13 48.5 6.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Rad17 PF03215.15 ETO20473.1 - 0.0089 16.0 1.5 0.013 15.4 1.4 1.4 1 1 0 1 1 1 1 Rad17 P-loop domain TniB PF05621.11 ETO20473.1 - 0.016 14.6 0.1 0.03 13.7 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_29 PF13555.6 ETO20473.1 - 0.019 14.7 0.9 0.051 13.3 0.0 2.2 3 0 0 3 3 3 0 P-loop containing region of AAA domain MMR_HSR1 PF01926.23 ETO20473.1 - 0.12 12.5 1.2 0.14 12.3 0.2 1.8 2 1 0 2 2 2 0 50S ribosome-binding GTPase Roc PF08477.13 ETO20473.1 - 0.13 12.5 2.4 0.17 12.1 0.0 2.4 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase KCNQ2_u3 PF16642.5 ETO20473.1 - 4 8.5 7.1 2.4 9.2 2.6 2.4 2 1 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 YqzH PF14164.6 ETO20474.1 - 0.031 14.3 0.7 0.17 12.0 0.7 2.3 1 0 0 1 1 1 0 YqzH-like protein Couple_hipA PF13657.6 ETO20474.1 - 0.22 12.2 0.3 16 6.2 0.1 2.9 2 1 1 3 3 3 0 HipA N-terminal domain B56 PF01603.20 ETO20475.1 - 7.6e-61 206.3 2.9 9.1e-61 206.1 2.9 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DUF4787 PF16029.5 ETO20475.1 - 0.024 14.7 0.0 0.048 13.7 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4787) DUF1380 PF07128.12 ETO20475.1 - 0.095 12.9 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1380) Caldesmon PF02029.15 ETO20476.1 - 0.00047 19.1 36.9 0.00066 18.6 36.9 1.2 1 0 0 1 1 1 1 Caldesmon DUF4094 PF13334.6 ETO20476.1 - 0.04 14.3 0.2 0.04 14.3 0.2 3.2 2 1 1 3 3 2 0 Domain of unknown function (DUF4094) GET2 PF08690.10 ETO20476.1 - 0.045 13.4 15.3 0.07 12.8 15.3 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 ABC2_membrane_3 PF12698.7 ETO20476.1 - 0.074 12.1 6.7 0.12 11.4 6.7 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein Peptidase_S64 PF08192.11 ETO20476.1 - 0.089 11.3 22.1 0.11 11.0 22.1 1.1 1 0 0 1 1 1 0 Peptidase family S64 Macoilin PF09726.9 ETO20476.1 - 0.19 10.3 21.7 0.25 9.9 21.7 1.2 1 0 0 1 1 1 0 Macoilin family BUD22 PF09073.10 ETO20476.1 - 0.82 8.9 43.6 1.3 8.3 39.6 2.1 2 0 0 2 2 2 0 BUD22 LAP1C PF05609.12 ETO20476.1 - 1.3 8.1 25.3 1.5 7.8 25.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DNA_pol_phi PF04931.13 ETO20476.1 - 1.5 6.8 39.1 3.3 5.7 39.1 1.6 1 0 0 1 1 1 0 DNA polymerase phi Hid1 PF12722.7 ETO20476.1 - 2.5 6.1 21.9 3.4 5.7 21.9 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Sin_N PF04801.13 ETO20476.1 - 4.7 6.3 21.7 7 5.7 21.7 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region TFIIF_alpha PF05793.12 ETO20476.1 - 7.1 5.1 44.1 9.4 4.7 44.1 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SDA1 PF05285.12 ETO20476.1 - 8.4 5.7 43.6 12 5.2 43.6 1.3 1 0 0 1 1 1 0 SDA1 WD40 PF00400.32 ETO20477.1 - 9.3e-10 39.0 2.7 0.00084 20.1 0.1 3.8 4 1 0 4 4 4 2 WD domain, G-beta repeat CDC45 PF02724.14 ETO20477.1 - 0.014 13.8 9.5 0.018 13.4 9.5 1.1 1 0 0 1 1 1 0 CDC45-like protein ANAPC4_WD40 PF12894.7 ETO20477.1 - 0.015 15.6 0.1 0.057 13.7 0.0 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Macoilin PF09726.9 ETO20477.1 - 0.34 9.4 16.8 0.43 9.1 16.8 1.1 1 0 0 1 1 1 0 Macoilin family CCSAP PF15748.5 ETO20477.1 - 0.37 10.9 18.3 0.54 10.4 18.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Zip PF02535.22 ETO20477.1 - 0.53 9.4 9.4 0.79 8.9 9.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Gti1_Pac2 PF09729.9 ETO20477.1 - 2.5 8.1 20.3 4.4 7.3 20.3 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family DEAD PF00270.29 ETO20481.1 - 9.4e-24 84.1 0.0 3.5e-23 82.3 0.0 2.0 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO20481.1 - 2.2e-09 37.6 2.0 3.5e-09 37.0 0.0 2.5 2 1 1 3 3 3 1 Helicase conserved C-terminal domain FancD2 PF14631.6 ETO20482.1 - 0.044 11.2 0.3 0.069 10.6 0.3 1.2 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PAS_12 PF18095.1 ETO20483.1 - 0.33 10.6 5.7 7.2 6.2 0.0 3.4 3 1 1 4 4 4 0 UPF0242 C-terminal PAS-like domain Yippee-Mis18 PF03226.14 ETO20484.1 - 3.2e-07 30.5 4.1 6.8e-07 29.5 4.0 1.9 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly V_ATPase_I PF01496.19 ETO20484.1 - 4.8e-05 21.5 6.6 5.7e-05 21.3 6.6 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Spc7 PF08317.11 ETO20484.1 - 0.00033 19.7 16.3 0.00041 19.3 16.3 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein ATG16 PF08614.11 ETO20484.1 - 0.0048 17.1 18.4 0.0073 16.6 18.4 1.3 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 ETO20484.1 - 0.005 16.9 6.9 0.005 16.9 6.9 3.5 2 1 1 3 3 2 1 bZIP transcription factor ERM PF00769.19 ETO20484.1 - 0.0096 15.8 17.9 0.014 15.2 17.9 1.2 1 0 0 1 1 1 1 Ezrin/radixin/moesin family DUF1664 PF07889.12 ETO20484.1 - 0.016 15.2 7.4 0.016 15.2 7.4 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) RasGAP_C PF03836.15 ETO20484.1 - 0.024 14.8 18.7 0.16 12.1 7.4 2.3 1 1 1 2 2 2 0 RasGAP C-terminus AbfS_sensor PF18225.1 ETO20484.1 - 0.057 13.3 0.6 0.29 11.0 0.0 2.2 2 0 0 2 2 2 0 Sensor histidine kinase (AbfS) sensor domain DUF4806 PF16064.5 ETO20484.1 - 0.062 13.6 3.0 0.15 12.3 2.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4806) SKA2 PF16740.5 ETO20484.1 - 0.087 12.6 17.1 0.59 9.9 17.0 2.3 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 Lebercilin PF15619.6 ETO20484.1 - 0.092 12.4 24.1 0.18 11.5 24.1 1.4 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Prominin PF05478.11 ETO20484.1 - 0.098 10.6 9.5 0.13 10.2 9.5 1.1 1 0 0 1 1 1 0 Prominin TolA_bind_tri PF16331.5 ETO20484.1 - 0.1 12.7 15.5 0.069 13.2 8.5 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation BDV_P24 PF06595.11 ETO20484.1 - 0.16 11.8 1.7 0.25 11.2 1.5 1.4 1 1 0 1 1 1 0 Borna disease virus P24 protein PEARLI-4 PF05278.12 ETO20484.1 - 0.19 11.3 15.5 0.12 12.0 13.7 1.5 1 1 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Cluap1 PF10234.9 ETO20484.1 - 0.19 11.1 15.3 0.28 10.5 15.3 1.1 1 0 0 1 1 1 0 Clusterin-associated protein-1 MAT1 PF06391.13 ETO20484.1 - 0.2 11.4 16.2 0.29 10.9 16.2 1.2 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 Nup188_C PF18378.1 ETO20484.1 - 0.2 10.4 5.5 0.28 10.0 5.5 1.2 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain DUF773 PF05600.12 ETO20484.1 - 0.22 10.2 14.5 0.31 9.7 14.5 1.3 1 0 0 1 1 1 0 CDK5 regulatory subunit-associated protein 3 Nup54 PF13874.6 ETO20484.1 - 0.23 11.5 15.0 0.41 10.8 15.0 1.4 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Flagellin_N PF00669.20 ETO20484.1 - 0.26 11.4 6.5 0.36 11.0 4.9 2.0 1 1 1 2 2 2 0 Bacterial flagellin N-terminal helical region GAS PF13851.6 ETO20484.1 - 0.27 10.6 24.9 0.04 13.3 19.3 2.0 1 1 0 1 1 1 0 Growth-arrest specific micro-tubule binding CorA PF01544.18 ETO20484.1 - 0.29 10.4 6.1 0.51 9.6 6.1 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein DUF3584 PF12128.8 ETO20484.1 - 0.33 8.4 15.6 0.41 8.1 15.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) CRR7 PF12095.8 ETO20484.1 - 0.36 11.3 7.2 0.14 12.7 2.1 2.6 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 HAUS6_N PF14661.6 ETO20484.1 - 0.38 10.3 13.6 0.63 9.6 13.6 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF812 PF05667.11 ETO20484.1 - 0.67 8.8 21.5 1.2 7.9 21.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) DivIC PF04977.15 ETO20484.1 - 0.86 9.4 20.9 10 6.0 7.9 3.2 1 1 2 3 3 3 0 Septum formation initiator HrpA_pilin PF09589.10 ETO20484.1 - 0.86 10.3 6.8 1.4 9.7 6.4 1.5 1 1 0 1 1 1 0 HrpA pilus formation protein DUF2680 PF10925.8 ETO20484.1 - 0.88 9.6 10.0 0.75 9.8 0.6 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2680) APG6_N PF17675.1 ETO20484.1 - 0.88 10.1 26.5 6.2 7.4 26.6 2.2 1 1 0 1 1 1 0 Apg6 coiled-coil region F-box-like_2 PF13013.6 ETO20484.1 - 0.97 9.4 5.4 1.3 9.1 0.6 2.5 1 1 1 2 2 2 0 F-box-like domain YabA PF06156.13 ETO20484.1 - 1.2 9.8 19.5 1.1e+02 3.5 19.5 2.7 1 1 0 1 1 1 0 Initiation control protein YabA DUF948 PF06103.11 ETO20484.1 - 1.3 9.4 5.1 4 7.8 4.9 2.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Med30 PF11315.8 ETO20484.1 - 1.3 9.2 14.3 2.2 8.4 14.3 1.3 1 0 0 1 1 1 0 Mediator complex subunit 30 Jnk-SapK_ap_N PF09744.9 ETO20484.1 - 1.3 9.2 22.0 2.8 8.2 22.0 1.5 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 PCRF PF03462.18 ETO20484.1 - 1.6 8.6 17.2 1.2 9.0 14.4 1.8 1 1 1 2 2 2 0 PCRF domain Fez1 PF06818.15 ETO20484.1 - 1.7 9.1 22.1 4.2 7.8 20.7 1.8 1 1 0 1 1 1 0 Fez1 Leu_zip PF15294.6 ETO20484.1 - 2 7.9 22.9 0.16 11.5 10.3 2.3 1 1 1 2 2 2 0 Leucine zipper GIT_CC PF16559.5 ETO20484.1 - 2.2 8.2 17.5 1.4 8.9 6.0 3.1 2 1 2 4 4 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor HlyD_2 PF12700.7 ETO20484.1 - 2.7 6.6 12.7 3.9 6.1 12.7 1.2 1 0 0 1 1 1 0 HlyD family secretion protein AHD PF17793.1 ETO20484.1 - 2.8 7.8 6.7 16 5.4 1.0 2.9 2 1 0 2 2 2 0 ANC1 homology domain (AHD) Occludin_ELL PF07303.13 ETO20484.1 - 2.9 8.7 15.1 0.76 10.5 7.8 2.3 1 1 1 2 2 2 0 Occludin homology domain BORCS8 PF10167.9 ETO20484.1 - 3 7.8 9.7 0.45 10.5 3.5 2.2 1 1 1 2 2 2 0 BLOC-1-related complex sub-unit 8 DUF4988 PF16378.5 ETO20484.1 - 3 7.5 6.3 1.3 8.7 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function TMPIT PF07851.13 ETO20484.1 - 3.3 6.9 18.1 7.5 5.7 18.1 1.6 1 1 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 ETO20484.1 - 4 5.9 18.9 6.7 5.2 18.4 1.5 1 1 0 1 1 1 0 Flagellar Assembly Protein A Prefoldin_2 PF01920.20 ETO20484.1 - 5.5 7.0 24.7 1.6 8.7 7.4 3.3 1 1 2 3 3 3 0 Prefoldin subunit Syntaxin_2 PF14523.6 ETO20484.1 - 5.5 7.4 14.2 18 5.8 3.5 2.1 1 1 1 2 2 2 0 Syntaxin-like protein ZapB PF06005.12 ETO20484.1 - 5.8 7.4 29.8 6.8 7.2 14.6 2.9 2 1 1 3 3 2 0 Cell division protein ZapB DASH_Dam1 PF08653.10 ETO20484.1 - 6.1 6.7 8.7 18 5.2 0.9 3.3 1 1 2 3 3 3 0 DASH complex subunit Dam1 SlyX PF04102.12 ETO20484.1 - 6.1 7.5 15.9 7.8 7.2 2.1 3.2 1 1 2 3 3 3 0 SlyX HALZ PF02183.18 ETO20484.1 - 6.3 7.1 21.3 0.84 9.9 8.9 3.5 1 1 1 3 3 3 0 Homeobox associated leucine zipper BMP2K_C PF15282.6 ETO20484.1 - 7 6.4 10.5 3.3 7.5 3.5 2.0 1 1 1 2 2 2 0 BMP-2-inducible protein kinase C-terminus Seryl_tRNA_N PF02403.22 ETO20484.1 - 7.9 6.8 22.2 13 6.1 16.6 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF3450 PF11932.8 ETO20484.1 - 8.1 5.7 17.8 4.4 6.5 10.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) SWI-SNF_Ssr4 PF08549.10 ETO20484.1 - 8.9 4.8 9.9 12 4.4 9.9 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) DHHA1 PF02272.19 ETO20484.1 - 9 6.7 11.8 3 8.3 1.2 2.4 2 0 0 2 2 2 0 DHHA1 domain Snf7 PF03357.21 ETO20485.1 - 6.2e-13 48.7 20.4 6.2e-13 48.7 20.4 1.5 1 1 1 2 2 2 1 Snf7 Helo_like_N PF17111.5 ETO20485.1 - 0.56 9.5 12.1 0.12 11.7 0.6 2.2 1 1 1 2 2 2 0 Fungal N-terminal domain of STAND proteins FKBP_N PF01346.18 ETO20485.1 - 1.5 9.9 11.4 8.8 7.4 11.4 2.1 1 1 0 1 1 1 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase PKD_channel PF08016.12 ETO20486.1 - 3.5e-09 35.8 12.9 3.5e-09 35.8 12.9 1.7 2 0 0 2 2 2 1 Polycystin cation channel Ion_trans PF00520.31 ETO20486.1 - 0.00011 21.6 30.2 0.00023 20.5 30.2 1.4 1 1 0 1 1 1 1 Ion transport protein MIT PF04212.18 ETO20488.1 - 2.5e-07 30.7 0.4 8e-07 29.0 0.4 1.8 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain DUF4530 PF15039.6 ETO20488.1 - 0.0032 17.6 12.0 0.0032 17.6 12.0 3.1 3 1 1 4 4 4 1 Domain of unknown function (DUF4530) LAP1C PF05609.12 ETO20488.1 - 0.46 9.5 19.8 0.67 9.0 19.8 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BUD22 PF09073.10 ETO20488.1 - 4.5 6.5 33.5 7 5.9 33.5 1.4 1 0 0 1 1 1 0 BUD22 Dapper PF15268.6 ETO20488.1 - 6.2 5.5 18.7 7.2 5.3 18.7 1.1 1 0 0 1 1 1 0 Dapper Exo_endo_phos PF03372.23 ETO20489.1 - 5.2e-06 26.1 0.0 8.1e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family CENP-Q PF13094.6 ETO20490.1 - 0.052 13.7 1.8 0.11 12.7 1.8 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit zf-H2C2_2 PF13465.6 ETO20491.1 - 2.7e-09 37.1 17.8 2.8e-07 30.7 0.2 4.0 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETO20491.1 - 0.19 12.2 31.4 0.067 13.7 2.9 5.5 5 1 0 5 5 5 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO20491.1 - 1.5 9.9 24.6 3.3 8.8 1.7 5.3 5 0 0 5 5 5 0 C2H2-type zinc finger DrrA_P4M PF14860.6 ETO20492.1 - 0.098 12.5 1.6 0.49 10.3 0.0 2.4 2 1 1 3 3 3 0 DrrA phosphatidylinositol 4-phosphate binding domain PAZ PF02170.22 ETO20493.1 - 0.0066 16.3 3.0 0.018 14.9 3.0 1.7 1 0 0 1 1 1 1 PAZ domain CsgE PF10627.9 ETO20493.1 - 0.099 12.9 0.0 0.26 11.5 0.0 1.7 1 0 0 1 1 1 0 Curli assembly protein CsgE RTC PF01137.21 ETO20495.1 - 0.18 11.0 0.6 1.7 7.8 0.0 2.4 3 0 0 3 3 3 0 RNA 3'-terminal phosphate cyclase Jagunal PF07086.12 ETO20495.1 - 0.49 10.4 7.8 0.35 10.9 5.9 1.6 1 1 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis Ribosomal_L20 PF00453.18 ETO20496.1 - 2.8e-11 43.5 1.7 5e-11 42.6 1.7 1.4 1 0 0 1 1 1 1 Ribosomal protein L20 Lung_7-TM_R PF06814.13 ETO20497.1 - 6.6e-27 94.5 12.5 8.5e-27 94.2 12.5 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor Beach PF02138.18 ETO20498.1 - 1.4e-74 250.9 0.0 1.8e-74 250.6 0.0 1.1 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO20498.1 - 4.6e-13 49.1 1.5 8.8e-13 48.2 1.5 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH SOBP PF15279.6 ETO20499.1 - 0.58 10.7 5.9 0.63 10.6 5.9 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 ETO20499.1 - 4.3 6.0 15.3 5 5.8 15.3 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO20499.1 - 4.9 5.3 18.4 6.8 4.9 18.4 1.3 1 0 0 1 1 1 0 CDC45-like protein TP53IP5 PF15331.6 ETO20499.1 - 5.5 7.1 13.5 6.9 6.7 13.5 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Kelch_3 PF13415.6 ETO20500.1 - 1.6e-08 34.6 0.5 1.2e-05 25.5 0.0 3.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO20500.1 - 3e-07 29.9 2.8 0.079 12.6 0.0 3.5 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ETO20500.1 - 1.9e-06 27.8 0.2 0.67 10.0 0.0 3.9 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO20500.1 - 2.3e-06 27.7 3.8 0.0035 17.6 0.1 4.6 4 1 1 5 5 5 1 Kelch motif Vps54_N PF10475.9 ETO20500.1 - 0.05 12.9 2.2 0.073 12.3 2.2 1.2 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex WD40 PF00400.32 ETO20501.1 - 1.3e-70 231.6 16.2 2.3e-12 47.2 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20501.1 - 1.7e-23 82.7 0.1 0.0012 19.1 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20501.1 - 4.9e-20 71.7 0.6 0.009 15.0 0.1 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO20501.1 - 2.3e-14 53.7 0.0 0.00022 21.2 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO20501.1 - 1.8e-09 36.8 1.4 0.027 13.1 0.0 4.7 1 1 4 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO20501.1 - 2.2e-08 33.8 0.9 0.00077 18.9 0.2 3.4 1 1 3 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO20501.1 - 2.4e-06 26.3 0.4 0.0023 16.6 0.1 3.1 1 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO20501.1 - 3.5e-06 26.8 13.8 4.2 7.4 0.1 7.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO20501.1 - 1.6e-05 24.4 2.4 0.95 8.7 0.0 4.7 1 1 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 ETO20501.1 - 0.00021 19.7 0.1 0.042 12.2 0.1 2.5 2 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz PALB2_WD40 PF16756.5 ETO20501.1 - 0.00095 18.2 0.1 0.77 8.6 0.0 3.3 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO20501.1 - 0.012 15.6 0.4 5.4 7.1 0.1 3.1 1 1 2 3 3 3 0 Family of unknown function (DUF5570) KH_1 PF00013.29 ETO20501.1 - 0.014 15.2 0.9 0.34 10.8 0.0 3.2 3 0 0 3 3 3 0 KH domain DPPIV_N PF00930.21 ETO20501.1 - 0.044 12.5 0.0 4.4 6.0 0.1 3.9 2 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETO20501.1 - 9.2 6.0 14.6 24 4.7 0.0 5.5 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Epimerase PF01370.21 ETO20502.1 - 1.9e-24 86.4 0.0 2.5e-24 86.1 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO20502.1 - 2.2e-21 76.6 0.0 2.9e-21 76.2 0.0 1.1 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase 3Beta_HSD PF01073.19 ETO20502.1 - 2.1e-08 33.5 0.0 2.9e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETO20502.1 - 1.3e-07 31.0 0.0 1.8e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 RmlD substrate binding domain Polysacc_synt_2 PF02719.15 ETO20502.1 - 4.7e-06 26.0 0.2 6.6e-06 25.5 0.2 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ETO20502.1 - 6.8e-06 26.1 0.2 1.2e-05 25.4 0.1 1.4 2 0 0 2 2 2 1 KR domain adh_short PF00106.25 ETO20502.1 - 2.4e-05 23.9 0.1 3.5e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase NAD_binding_4 PF07993.12 ETO20502.1 - 6.4e-05 22.2 0.0 0.1 11.7 0.0 2.2 2 0 0 2 2 2 2 Male sterility protein Sacchrp_dh_NADP PF03435.18 ETO20502.1 - 0.00039 20.7 0.1 0.00062 20.0 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 ETO20502.1 - 0.008 16.1 0.0 0.011 15.6 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ETO20502.1 - 0.0091 15.6 0.0 0.013 15.0 0.0 1.3 1 0 0 1 1 1 1 NmrA-like family ThiF PF00899.21 ETO20502.1 - 0.017 14.5 0.8 0.038 13.4 0.2 1.7 1 1 1 2 2 2 0 ThiF family Shikimate_DH PF01488.20 ETO20502.1 - 0.079 13.0 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase GDP_Man_Dehyd PF16363.5 ETO20503.1 - 2.8e-07 30.3 0.0 0.012 15.1 0.0 2.1 2 0 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETO20503.1 - 4.1e-05 23.2 0.0 8.3e-05 22.2 0.0 1.5 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Skp1_POZ PF03931.15 ETO20504.1 - 0.0059 16.8 0.3 1.8 8.8 0.1 2.4 1 1 1 2 2 2 2 Skp1 family, tetramerisation domain Nrf1_DNA-bind PF10491.9 ETO20504.1 - 0.076 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 NLS-binding and DNA-binding and dimerisation domains of Nrf1 MIT PF04212.18 ETO20505.1 - 0.019 15.0 2.7 0.043 13.9 1.6 2.1 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain PBP1_TM PF14812.6 ETO20505.1 - 0.035 14.5 12.6 0.035 14.5 12.6 2.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Presenilin PF01080.17 ETO20505.1 - 0.095 11.5 3.1 0.14 10.9 3.1 1.2 1 0 0 1 1 1 0 Presenilin DUF3402 PF11882.8 ETO20505.1 - 0.35 9.9 7.8 0.32 10.0 7.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3402) DUF5520 PF17658.1 ETO20505.1 - 0.38 9.8 8.8 0.069 12.3 4.9 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5520) PI3K_1B_p101 PF10486.9 ETO20505.1 - 0.97 7.1 6.0 1.2 6.8 6.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RXT2_N PF08595.11 ETO20505.1 - 5.7 6.9 18.4 1 9.4 9.6 2.4 2 1 0 2 2 2 0 RXT2-like, N-terminal Sin_N PF04801.13 ETO20506.1 - 0.0001 21.7 2.7 0.00011 21.6 2.7 1.0 1 0 0 1 1 1 1 Sin-like protein conserved region RR_TM4-6 PF06459.12 ETO20506.1 - 0.014 15.2 4.6 0.016 15.1 4.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF913 PF06025.12 ETO20506.1 - 0.02 13.9 1.0 0.023 13.7 1.0 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3292 PF11696.8 ETO20506.1 - 0.02 13.3 1.5 0.023 13.1 1.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) DUF3464 PF11947.8 ETO20506.1 - 0.061 13.1 0.1 0.064 13.0 0.1 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Cellulose_synt PF03552.14 ETO20506.1 - 0.073 11.6 0.9 0.089 11.3 0.9 1.0 1 0 0 1 1 1 0 Cellulose synthase Connexin PF00029.19 ETO20506.1 - 0.11 12.2 1.8 0.14 11.9 1.8 1.1 1 0 0 1 1 1 0 Connexin NPIP PF06409.11 ETO20506.1 - 1.9 7.5 6.1 2.7 7.0 6.1 1.2 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Presenilin PF01080.17 ETO20506.1 - 7 5.3 6.5 9.3 4.9 6.5 1.1 1 0 0 1 1 1 0 Presenilin CMS1 PF14617.6 ETO20506.1 - 8.6 5.6 8.5 11 5.3 8.5 1.1 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit DUF4484 PF14831.6 ETO20507.1 - 0.11 12.5 0.1 0.11 12.5 0.1 3.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4484) AIF_C PF14721.6 ETO20507.1 - 0.37 11.2 0.0 0.37 11.2 0.0 3.9 3 1 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF913 PF06025.12 ETO20507.1 - 0.76 8.7 0.0 0.76 8.7 0.0 2.9 2 2 1 4 4 4 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 ETO20507.1 - 5.1 6.8 18.8 15 5.2 0.0 3.4 3 0 0 3 3 3 0 Connexin Kelch_6 PF13964.6 ETO20508.1 - 0.00019 21.6 0.1 0.00093 19.4 0.0 2.3 2 0 0 2 2 2 1 Kelch motif Nuc_sug_transp PF04142.15 ETO20509.1 - 6.9e-30 104.3 7.8 7.8e-30 104.1 7.8 1.0 1 0 0 1 1 1 1 Nucleotide-sugar transporter UAA PF08449.11 ETO20509.1 - 3.1e-09 36.5 5.5 1.2e-08 34.5 5.5 1.8 1 1 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO20509.1 - 0.0012 19.0 15.6 0.0098 16.1 1.7 2.4 2 1 0 2 2 2 2 EamA-like transporter family Phage_holin_5_2 PF16079.5 ETO20509.1 - 0.013 15.8 2.7 0.8 10.1 0.0 2.5 2 0 0 2 2 2 0 Phage holin family Hol44, in holin superfamily V MFS_1 PF07690.16 ETO20509.1 - 0.31 9.9 12.8 1.1 8.1 12.8 1.9 1 1 0 1 1 1 0 Major Facilitator Superfamily Bax1-I PF01027.20 ETO20509.1 - 0.77 9.6 10.8 20 4.9 10.8 2.1 1 1 0 1 1 1 0 Inhibitor of apoptosis-promoting Bax1 DUF4131 PF13567.6 ETO20509.1 - 4.5 6.9 6.2 1 9.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) UCH PF00443.29 ETO20510.1 - 2e-42 145.5 4.8 2e-42 145.5 4.8 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO20510.1 - 5e-19 69.0 11.5 2.3e-18 66.9 11.5 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase FANCI_S4 PF14678.6 ETO20510.1 - 0.013 14.7 1.0 0.028 13.6 0.1 2.0 2 0 0 2 2 2 0 FANCI solenoid 4 Presenilin PF01080.17 ETO20510.1 - 5.9 5.5 15.1 0.3 9.8 2.5 2.3 2 0 0 2 2 2 0 Presenilin Raftlin PF15250.6 ETO20510.1 - 8.2 5.0 9.9 0.84 8.3 3.2 2.1 2 0 0 2 2 2 0 Raftlin Trypan_PARP PF05887.11 ETO20510.1 - 9.3 6.2 12.3 0.37 10.8 6.1 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) zf-H2C2_2 PF13465.6 ETO20513.1 - 3.4e-09 36.7 28.7 0.0054 17.1 0.2 5.1 5 1 0 5 5 5 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO20513.1 - 5.6e-06 26.8 31.3 0.0007 20.2 0.4 5.4 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO20513.1 - 0.0001 22.6 0.5 0.0001 22.6 0.5 6.0 5 2 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_11 PF16622.5 ETO20513.1 - 0.00019 21.1 4.6 0.0089 15.8 1.1 3.8 4 0 0 4 4 3 2 zinc-finger C2H2-type zf-Di19 PF05605.12 ETO20513.1 - 0.00027 21.2 20.7 0.01 16.1 4.1 3.6 3 0 0 3 3 3 2 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_6 PF13912.6 ETO20513.1 - 0.00034 20.5 0.6 0.00034 20.5 0.6 5.5 5 1 0 5 5 5 2 C2H2-type zinc finger zf-met PF12874.7 ETO20513.1 - 0.0018 18.6 21.3 0.26 11.7 0.3 5.4 5 0 0 5 5 5 2 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 ETO20513.1 - 0.0054 17.4 2.2 0.0054 17.4 2.2 3.1 2 1 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats SpoIID PF08486.10 ETO20513.1 - 0.25 11.9 1.2 0.49 11.0 0.2 1.9 2 0 0 2 2 2 0 Stage II sporulation protein TF_Zn_Ribbon PF08271.12 ETO20513.1 - 0.4 10.2 4.8 0.32 10.5 0.8 2.8 3 0 0 3 3 3 0 TFIIB zinc-binding zf-C2H2_9 PF16293.5 ETO20513.1 - 0.83 9.5 9.9 2.6 8.0 1.2 4.0 3 1 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf_UBZ PF18439.1 ETO20513.1 - 1.2 8.7 8.7 2.1 8.0 0.2 3.5 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger C1_4 PF07975.12 ETO20513.1 - 2.4 8.5 20.5 19 5.5 0.2 4.5 2 1 3 5 5 5 0 TFIIH C1-like domain GAGA PF09237.11 ETO20513.1 - 5.6 6.8 26.1 1.3 8.9 0.1 5.1 3 1 3 6 6 6 0 GAGA factor Gemini_mov PF01708.16 ETO20514.1 - 0.0012 18.6 0.6 0.053 13.3 0.1 2.3 2 0 0 2 2 2 2 Geminivirus putative movement protein Pox_LP_H2 PF03356.15 ETO20515.1 - 0.29 11.0 5.1 0.16 11.9 0.3 2.3 2 0 0 2 2 2 0 Viral late protein H2 Peptidase_U32 PF01136.19 ETO20517.1 - 0.05 12.7 1.8 0.084 12.0 0.5 1.8 1 1 1 2 2 2 0 Peptidase family U32 FdsD PF11390.8 ETO20519.1 - 0.011 16.1 0.5 7.5 7.0 0.0 2.7 2 0 0 2 2 2 0 NADH-dependant formate dehydrogenase delta subunit FdsD Latarcin PF10279.9 ETO20519.1 - 0.39 11.2 7.2 0.13 12.6 0.9 2.4 2 0 0 2 2 2 0 Latarcin precursor Cytochrom_C_2 PF01322.20 ETO20519.1 - 0.58 11.1 3.8 0.56 11.1 0.5 2.3 1 1 1 2 2 2 0 Cytochrome C' V_ATPase_I PF01496.19 ETO20520.1 - 8.6e-93 311.7 10.2 1e-92 311.5 10.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family PIG-P PF08510.12 ETO20520.1 - 0.19 11.6 2.3 1.3 9.0 1.9 2.5 1 1 1 2 2 2 0 PIG-P WD40 PF00400.32 ETO20521.1 - 8.3e-35 118.2 20.5 4.4e-07 30.5 1.1 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO20521.1 - 1.4e-11 43.7 2.6 0.041 12.5 0.0 5.8 2 2 2 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO20521.1 - 2.1e-11 44.0 4.0 0.25 11.7 0.0 6.1 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO20521.1 - 0.0043 17.7 10.2 0.0077 16.9 9.0 2.1 1 1 0 1 1 1 1 TRAF-type zinc finger Zip PF02535.22 ETO20524.1 - 0.12 11.6 0.5 0.16 11.2 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO20524.1 - 0.49 8.6 15.4 0.51 8.6 15.4 1.1 1 0 0 1 1 1 0 CDC45-like protein PI3K_1B_p101 PF10486.9 ETO20524.1 - 0.97 7.1 7.5 1.1 7.0 7.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit HEAT PF02985.22 ETO20525.1 - 0.0018 18.4 5.8 1.4 9.3 0.0 4.5 5 1 0 5 5 5 3 HEAT repeat SPC12 PF06645.13 ETO20526.1 - 0.18 11.9 3.6 0.36 10.9 3.6 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DHC_N2 PF08393.13 ETO20527.1 - 2.9e-108 362.5 34.8 2.6e-56 191.5 0.9 3.4 3 1 1 4 4 4 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 ETO20527.1 - 4.7e-55 186.9 0.6 1e-54 185.7 0.1 1.9 2 0 0 2 2 2 1 Hydrolytic ATP binding site of dynein motor region AAA PF00004.29 ETO20527.1 - 0.0013 19.1 0.7 0.035 14.5 0.1 3.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RF-1 PF00472.20 ETO20527.1 - 0.0038 17.1 0.1 0.12 12.3 0.1 2.7 2 1 0 2 2 2 1 RF-1 domain AAA_5 PF07728.14 ETO20527.1 - 0.028 14.4 0.0 0.51 10.3 0.0 2.9 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETO20527.1 - 0.091 13.3 0.2 1.3 9.6 0.0 3.0 2 0 0 2 2 2 0 AAA domain HTH_1 PF00126.27 ETO20527.1 - 0.15 12.0 0.0 0.48 10.4 0.0 1.8 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family PP2C_C PF07830.13 ETO20527.1 - 0.19 12.2 0.6 1.2 9.7 0.1 2.6 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain Nre_C PF04895.12 ETO20527.1 - 2 8.4 4.3 1.3 9.0 0.0 2.8 4 0 0 4 4 4 0 Archaeal Nre, C-terminal Chordopox_G3 PF06129.12 ETO20529.1 - 0.33 11.7 0.1 0.33 11.7 0.1 2.6 2 0 0 2 2 2 0 Chordopoxvirus G3 protein Macoilin PF09726.9 ETO20529.1 - 2 6.9 12.2 0.28 9.7 5.3 2.2 2 0 0 2 2 2 0 Macoilin family HATPase_c PF02518.26 ETO20530.1 - 0.0027 18.2 0.0 0.0046 17.5 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO20530.1 - 0.017 15.0 0.4 0.03 14.1 0.3 1.5 1 1 0 1 1 1 0 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase LEF-9 PF05094.12 ETO20531.1 - 0.048 12.2 0.2 0.08 11.5 0.1 1.4 2 0 0 2 2 2 0 Late expression factor 9 (LEF-9) Taeniidae_ag PF05596.11 ETO20531.1 - 0.091 12.8 0.1 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Taeniidae antigen DHC_N1 PF08385.12 ETO20533.1 - 4.2e-95 319.5 19.2 1.2e-73 248.7 12.2 2.3 2 0 0 2 2 2 2 Dynein heavy chain, N-terminal region 1 DUF919 PF06034.11 ETO20533.1 - 0.011 15.5 0.1 0.046 13.6 0.1 2.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus protein of unknown function (DUF919) FAA_hydro_N_2 PF18288.1 ETO20533.1 - 0.037 14.4 0.2 3.3 8.2 0.0 3.3 3 0 0 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 MA-Mit PF09245.10 ETO20533.1 - 0.45 10.0 10.3 0.14 11.6 1.1 3.2 1 1 1 3 3 3 0 Mycoplasma arthritidis-derived mitogen HAD_2 PF13419.6 ETO20533.1 - 0.54 10.3 4.4 2.4 8.2 0.1 3.4 3 0 0 3 3 3 0 Haloacid dehalogenase-like hydrolase Sas10 PF09368.10 ETO20534.1 - 0.0018 18.7 8.6 0.0018 18.7 8.6 2.3 2 0 0 2 2 2 1 Sas10 C-terminal domain DUF3141 PF11339.8 ETO20534.1 - 0.11 10.8 0.5 0.14 10.5 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) PEARLI-4 PF05278.12 ETO20534.1 - 4.5 6.8 13.7 5.6 6.5 13.7 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Iwr1 PF08574.10 ETO20534.1 - 5.4 8.1 9.8 8.3 7.5 9.8 1.3 1 0 0 1 1 1 0 Transcription factor Iwr1 APG17 PF04108.12 ETO20535.1 - 0.00018 20.7 0.5 0.00018 20.7 0.5 2.4 3 1 1 4 4 4 1 Autophagy protein Apg17 ABC2_membrane_5 PF13346.6 ETO20537.1 - 0.0026 17.3 4.8 0.0054 16.3 4.8 1.6 1 1 0 1 1 1 1 ABC-2 family transporter protein DUF383 PF04063.14 ETO20539.1 - 0.0014 18.3 2.2 0.0044 16.7 0.3 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF383) ACDC PF14733.6 ETO20539.1 - 4.8 7.6 6.3 28 5.1 0.3 3.6 3 0 0 3 3 3 0 AP2-coincident C-terminal ubiquitin PF00240.23 ETO20541.1 - 2.4e-12 46.4 0.2 3.9e-12 45.7 0.2 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO20541.1 - 2.6e-05 23.9 0.1 4.8e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Rad60-SLD_2 PF13881.6 ETO20541.1 - 0.0002 21.5 0.2 0.00043 20.3 0.1 1.7 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2847 PF11009.8 ETO20541.1 - 0.038 13.9 0.1 0.074 13.0 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2847) ADP_ribosyl_GH PF03747.14 ETO20543.1 - 2e-29 103.3 0.0 2.3e-28 99.8 0.0 2.1 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase SLC35F PF06027.12 ETO20544.1 - 1.5e-32 113.4 2.9 3.2e-32 112.2 2.9 1.6 1 0 0 1 1 1 1 Solute carrier family 35 UAA PF08449.11 ETO20544.1 - 4.6e-06 26.0 0.3 9.7e-06 25.0 0.3 1.5 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO20544.1 - 5.4e-06 26.6 9.8 1.3e-05 25.3 1.9 2.7 3 0 0 3 3 3 2 EamA-like transporter family CRT-like PF08627.10 ETO20544.1 - 3.4e-05 23.0 0.4 6.5e-05 22.0 0.4 1.4 2 0 0 2 2 2 1 CRT-like, chloroquine-resistance transporter-like Holin_BhlA PF10960.8 ETO20544.1 - 0.28 11.2 2.4 0.36 10.8 0.2 2.3 2 0 0 2 2 2 0 BhlA holin family Beach PF02138.18 ETO20545.1 - 9.8e-105 349.9 0.0 1.6e-104 349.2 0.0 1.3 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO20545.1 - 5e-07 29.7 2.3 3.7e-05 23.8 1.1 3.2 2 1 0 2 2 2 1 PH domain associated with Beige/BEACH GRAM PF02893.20 ETO20545.1 - 0.0064 16.4 0.1 0.049 13.5 0.0 2.4 2 0 0 2 2 2 1 GRAM domain WD40 PF00400.32 ETO20546.1 - 8.5e-18 64.4 23.9 0.00044 21.0 1.6 7.0 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20546.1 - 1.1e-06 28.8 0.3 0.19 12.1 0.0 4.5 3 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO20546.1 - 0.037 13.3 0.6 0.32 10.3 0.0 2.5 2 1 0 2 2 2 0 WD40-like domain Senescence_reg PF04520.13 ETO20546.1 - 0.21 12.4 4.5 0.43 11.4 4.5 1.5 1 0 0 1 1 1 0 Senescence regulator ACBP PF00887.19 ETO20547.1 - 2.9e-12 46.6 0.1 7.9e-12 45.2 0.1 1.7 1 0 0 1 1 1 1 Acyl CoA binding protein FR47 PF08445.10 ETO20547.1 - 2.5e-05 24.1 0.0 5.8e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_10 PF13673.7 ETO20547.1 - 4e-05 23.6 0.1 9.9e-05 22.3 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO20547.1 - 7e-05 23.1 0.0 0.00022 21.4 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO20547.1 - 0.0076 16.7 0.1 0.03 14.7 0.1 2.0 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain IBD PF10416.9 ETO20547.1 - 0.019 15.0 0.0 0.051 13.6 0.0 1.7 1 0 0 1 1 1 0 Transcription-initiator DNA-binding domain IBD Lebercilin PF15619.6 ETO20547.1 - 0.11 12.1 3.0 0.18 11.4 3.0 1.2 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease V_ATPase_I PF01496.19 ETO20548.1 - 4.1 5.2 12.0 4.2 5.2 12.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MIP PF00230.20 ETO20549.1 - 0.00019 21.2 6.5 0.0011 18.8 6.6 1.8 1 1 0 1 1 1 1 Major intrinsic protein Pneumo_att_G PF05539.11 ETO20550.1 - 0.018 14.6 2.5 0.023 14.3 2.5 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Xol-1_GHMP-like PF09109.10 ETO20550.1 - 0.047 13.6 0.7 0.086 12.7 0.7 1.4 1 0 0 1 1 1 0 Switch protein XOL-1, GHMP-like RGS PF00615.19 ETO20550.1 - 0.058 13.7 0.7 0.13 12.5 0.7 1.6 1 0 0 1 1 1 0 Regulator of G protein signaling domain Pannexin_like PF12534.8 ETO20551.1 - 8 5.4 7.2 9.4 5.2 7.2 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 PRORP PF16953.5 ETO20552.1 - 0.042 13.4 0.0 0.085 12.4 0.0 1.5 1 0 0 1 1 1 0 Protein-only RNase P 7tm_1 PF00001.21 ETO20554.1 - 0.055 12.8 0.4 0.11 11.9 0.4 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) TPR_1 PF00515.28 ETO20556.1 - 5.4e-12 45.0 7.0 0.0024 17.6 0.0 6.4 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO20556.1 - 3.5e-11 42.7 2.5 0.21 12.0 0.0 5.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO20556.1 - 9.7e-11 40.9 17.9 0.0017 18.3 0.0 7.3 6 1 1 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO20556.1 - 6.1e-09 36.1 4.8 8.2e-06 26.0 0.2 4.8 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO20556.1 - 2.5e-06 27.3 3.9 0.012 15.8 0.0 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO20556.1 - 9.7e-06 25.9 0.6 0.51 11.1 0.0 4.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO20556.1 - 1.4e-05 24.7 2.0 0.029 14.0 0.0 4.3 3 1 1 4 4 4 1 TPR repeat TPR_19 PF14559.6 ETO20556.1 - 5.8e-05 23.5 3.2 0.83 10.2 0.0 4.5 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO20556.1 - 0.00014 22.4 1.5 7.2 7.7 0.0 4.8 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO20556.1 - 0.00044 20.9 5.8 0.1 13.2 0.0 4.7 4 1 2 6 6 6 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO20556.1 - 0.0014 18.7 0.2 0.12 12.5 0.0 3.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO20556.1 - 0.012 14.9 1.4 0.85 8.8 0.1 2.4 2 1 1 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO20556.1 - 0.012 15.8 1.9 0.012 15.8 1.9 3.2 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ETO20556.1 - 0.3 11.0 1.6 9.7 6.2 0.1 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3405 PF11885.8 ETO20557.1 - 1.6 7.3 14.1 1.7 7.2 14.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3405) Connexin PF00029.19 ETO20557.1 - 1.8 8.3 10.2 1.9 8.2 10.2 1.1 1 0 0 1 1 1 0 Connexin YqfQ PF14181.6 ETO20557.1 - 2.3 8.4 12.4 2.6 8.2 12.4 1.1 1 0 0 1 1 1 0 YqfQ-like protein Ureide_permease PF07168.11 ETO20557.1 - 2.3 6.9 6.7 2.3 6.9 6.7 1.0 1 0 0 1 1 1 0 Ureide permease MAP17 PF15807.5 ETO20557.1 - 3.1 8.1 12.1 3.9 7.7 12.1 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 O-antigen_lig PF13425.6 ETO20557.1 - 4.6 5.9 10.3 4.9 5.8 10.3 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein U79_P34 PF03064.16 ETO20557.1 - 6 6.1 16.9 7 5.9 16.9 1.1 1 0 0 1 1 1 0 HSV U79 / HCMV P34 FANCI_S4 PF14678.6 ETO20557.1 - 9.1 5.3 17.3 23 4.0 17.3 1.7 1 1 0 1 1 1 0 FANCI solenoid 4 TPR_12 PF13424.6 ETO20558.1 - 2.1e-16 60.0 1.0 2e-07 31.2 0.0 3.2 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO20558.1 - 7.7e-08 32.0 0.0 0.0023 17.8 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO20558.1 - 0.00027 20.7 0.4 7.6 6.8 0.0 3.9 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO20558.1 - 0.057 13.3 16.0 0.71 9.8 0.5 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO20558.1 - 0.14 12.6 9.3 44 4.8 0.9 4.5 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO20558.1 - 0.37 11.1 11.6 2 8.9 1.1 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat YnfE PF17452.2 ETO20558.1 - 0.81 10.0 3.1 1.9 8.8 0.1 2.7 3 0 0 3 3 3 0 Uncharacterized YnfE-like TPR_2 PF07719.17 ETO20558.1 - 0.96 9.7 9.1 2.6 8.4 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat PBP1_TM PF14812.6 ETO20560.1 - 0.0013 19.0 3.9 0.0013 19.0 3.9 3.6 4 0 0 4 4 4 1 Transmembrane domain of transglycosylase PBP1 at N-terminal eIF-3c_N PF05470.12 ETO20560.1 - 0.02 13.2 0.0 0.032 12.5 0.0 1.5 1 1 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus GCIP PF13324.6 ETO20560.1 - 7.8 6.0 12.8 0.15 11.6 1.7 2.2 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting SDA1 PF05285.12 ETO20560.1 - 10 5.5 18.3 0.12 11.8 2.8 2.2 2 0 0 2 2 2 0 SDA1 Presenilin PF01080.17 ETO20561.1 - 5.5 5.6 13.2 1.1 7.9 9.6 1.6 2 0 0 2 2 2 0 Presenilin SLC12 PF03522.15 ETO20561.1 - 5.7 5.9 10.3 9.2 5.2 10.3 1.3 1 0 0 1 1 1 0 Solute carrier family 12 NOA36 PF06524.12 ETO20562.1 - 0.79 9.0 9.4 0.94 8.7 9.4 1.1 1 0 0 1 1 1 0 NOA36 protein HAMP PF00672.25 ETO20563.1 - 0.028 14.8 0.1 0.061 13.7 0.1 1.5 1 0 0 1 1 1 0 HAMP domain YqaJ PF09588.10 ETO20564.1 - 9.9e-06 25.8 0.0 2.1e-05 24.7 0.0 1.6 1 1 0 1 1 1 1 YqaJ-like viral recombinase domain zf-AN1 PF01428.16 ETO20566.1 - 0.014 15.5 1.0 0.028 14.6 1.0 1.5 1 0 0 1 1 1 0 AN1-like Zinc finger zf-TRAF PF02176.18 ETO20568.1 - 1.7e-06 28.6 7.0 5.3e-06 27.0 7.0 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger Mo25 PF08569.11 ETO20569.1 - 0.0058 16.0 0.1 0.01 15.2 0.1 1.3 1 0 0 1 1 1 1 Mo25-like Integrin_b_cyt PF08725.11 ETO20569.1 - 9.2 6.0 9.3 15 5.3 1.1 3.2 3 0 0 3 3 3 0 Integrin beta cytoplasmic domain Kazal_2 PF07648.15 ETO20570.1 - 0.013 15.7 0.2 0.052 13.7 0.2 2.1 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain PRIMA1 PF16101.5 ETO20571.1 - 0.33 11.0 8.4 0.54 10.3 8.4 1.3 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RBD PF02196.15 ETO20573.1 - 0.054 13.6 0.1 0.093 12.8 0.1 1.4 1 0 0 1 1 1 0 Raf-like Ras-binding domain MatP_C PF17414.2 ETO20574.1 - 0.19 12.0 3.8 0.13 12.5 1.3 2.0 1 1 1 2 2 2 0 MatP C-terminal ribbon-helix-helix domain APG6_N PF17675.1 ETO20575.1 - 0.0023 18.4 6.4 0.0049 17.4 6.4 1.5 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF2353 PF09789.9 ETO20575.1 - 0.0026 17.2 5.3 0.0026 17.2 5.3 1.4 2 0 0 2 2 2 1 Uncharacterized coiled-coil protein (DUF2353) Tropomyosin PF00261.20 ETO20575.1 - 0.0042 16.5 7.5 0.0066 15.8 7.5 1.3 1 0 0 1 1 1 1 Tropomyosin bZIP_2 PF07716.15 ETO20575.1 - 0.0092 16.0 0.7 0.0092 16.0 0.7 3.2 2 1 1 3 3 3 1 Basic region leucine zipper Nup54 PF13874.6 ETO20575.1 - 0.04 14.0 1.4 0.068 13.3 1.4 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 Anti-adapt_IraP PF10796.9 ETO20575.1 - 0.058 14.0 3.4 0.49 11.0 3.4 2.2 1 1 0 1 1 1 0 Sigma-S stabilisation anti-adaptor protein MCC-bdg_PDZ PF10506.9 ETO20575.1 - 0.068 13.2 0.7 0.15 12.1 0.7 1.6 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome CLZ PF16526.5 ETO20575.1 - 0.31 11.4 10.4 0.52 10.7 3.3 2.3 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF16 PF01519.16 ETO20575.1 - 0.36 11.3 7.7 0.63 10.6 7.7 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 ZapB PF06005.12 ETO20575.1 - 0.8 10.2 7.6 5.1 7.6 7.6 2.2 1 1 0 1 1 1 0 Cell division protein ZapB SOGA PF11365.8 ETO20575.1 - 0.94 10.6 6.1 1.1 10.4 0.7 2.5 2 1 0 2 2 2 0 Protein SOGA YabA PF06156.13 ETO20575.1 - 4.2 8.0 7.9 3.8 8.2 1.8 2.5 2 1 1 3 3 2 0 Initiation control protein YabA DivIC PF04977.15 ETO20575.1 - 9.6 6.1 7.7 2.4 8.0 1.0 2.5 1 1 1 2 2 2 0 Septum formation initiator tRNA_anti-like PF12869.7 ETO20576.1 - 0.089 12.4 1.5 1.3 8.6 0.1 2.4 2 0 0 2 2 2 0 tRNA_anti-like Sec62 PF03839.16 ETO20576.1 - 1 8.9 10.8 1.7 8.1 10.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Coilin_N PF15862.5 ETO20577.1 - 0.46 10.3 10.3 0.49 10.2 10.3 1.1 1 0 0 1 1 1 0 Coilin N-terminus FAM176 PF14851.6 ETO20577.1 - 0.95 9.1 6.5 1.1 9.0 6.5 1.1 1 0 0 1 1 1 0 FAM176 family WD40 PF00400.32 ETO20579.1 - 2.7e-32 110.3 4.8 7.8e-11 42.4 0.2 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO20579.1 - 2e-14 53.3 0.1 0.0009 18.3 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO20579.1 - 3.2e-13 49.8 0.1 3e-05 24.2 0.1 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO20579.1 - 2.5e-08 33.7 1.2 0.29 11.1 0.3 4.2 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO20579.1 - 9e-08 32.2 0.0 3.6e-05 23.7 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO20579.1 - 2.7e-05 23.0 1.3 0.05 12.3 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETO20579.1 - 0.0026 17.4 5.6 7.8 6.3 0.0 4.8 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature DPPIV_N PF00930.21 ETO20579.1 - 0.0075 15.1 0.0 0.19 10.5 0.0 2.5 2 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Coatomer_WDAD PF04053.14 ETO20579.1 - 0.019 14.0 0.0 0.061 12.4 0.0 1.6 1 1 0 1 1 1 0 Coatomer WD associated region Nbas_N PF15492.6 ETO20579.1 - 0.023 14.1 0.3 3.2 7.0 0.1 2.9 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ETO20579.1 - 0.036 13.4 0.0 1.9 7.8 0.0 2.1 1 1 1 2 2 2 0 WD40-like domain DUF1258 PF06869.12 ETO20579.1 - 0.089 12.3 0.0 0.44 10.0 0.0 1.9 1 1 2 3 3 3 0 Protein of unknown function (DUF1258) ssDBP_DBD PF18361.1 ETO20579.1 - 0.16 12.1 0.0 2.1 8.5 0.0 2.6 2 2 2 4 4 4 0 Single stranded DNA-binding protein ss DNA binding domain DCAF15_WD40 PF14939.6 ETO20581.1 - 0.089 12.4 2.5 0.14 11.8 2.5 1.3 1 0 0 1 1 1 0 DDB1-and CUL4-substrate receptor 15, WD repeat ANTH PF07651.16 ETO20582.1 - 4.1e-13 49.0 0.1 6.3e-13 48.3 0.1 1.2 1 0 0 1 1 1 1 ANTH domain ENTH PF01417.20 ETO20582.1 - 1.8e-05 24.8 0.0 2.6e-05 24.2 0.0 1.4 1 1 0 1 1 1 1 ENTH domain RIBIOP_C PF04950.12 ETO20582.1 - 0.089 12.2 0.0 0.14 11.6 0.0 1.2 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal REJ PF02010.15 ETO20583.1 - 9.9e-08 31.2 0.1 1.8e-07 30.3 0.1 1.4 1 0 0 1 1 1 1 REJ domain Atg31 PF09795.9 ETO20583.1 - 0.01 15.9 0.2 0.18 11.8 0.1 2.4 2 0 0 2 2 2 0 Autophagy-related protein 31 PhnA_Zn_Ribbon PF08274.12 ETO20583.1 - 0.014 15.4 1.7 0.15 12.0 0.1 2.5 2 0 0 2 2 2 0 PhnA Zinc-Ribbon WD40 PF00400.32 ETO20584.1 - 1.8e-65 215.3 20.4 1.6e-10 41.4 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20584.1 - 7.4e-20 71.1 0.6 0.028 14.7 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20584.1 - 7.4e-11 41.6 0.4 0.18 10.7 0.0 6.2 1 1 6 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO20584.1 - 1.8e-08 34.1 0.5 0.045 13.1 0.0 3.6 1 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO20584.1 - 1.4e-06 27.3 4.5 0.4 9.3 0.0 4.8 1 1 2 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO20584.1 - 2.1e-06 27.5 9.2 6.9 6.7 0.0 7.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO20584.1 - 0.00048 19.0 6.5 0.16 10.7 0.3 4.2 2 1 2 5 5 5 2 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO20584.1 - 0.00052 19.2 0.3 0.66 9.0 0.1 2.2 1 1 1 2 2 2 2 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO20584.1 - 0.00094 17.8 0.1 0.05 12.1 0.0 2.6 1 1 1 3 3 3 1 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO20584.1 - 0.0012 18.9 2.5 8.1 6.6 0.0 4.9 1 1 5 6 6 6 1 Family of unknown function (DUF5570) MMS1_N PF10433.9 ETO20584.1 - 0.0025 16.5 0.5 2 7.0 0.0 3.6 3 1 0 4 4 4 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term nos_propeller PF18764.1 ETO20584.1 - 0.0033 17.3 0.1 21 5.1 0.0 4.4 4 1 1 5 5 5 0 Nitrous oxide reductase propeller repeat AcetylCoA_hyd_C PF13336.6 ETO20584.1 - 0.041 13.8 0.0 2.3 8.1 0.0 2.8 3 0 0 3 3 3 0 Acetyl-CoA hydrolase/transferase C-terminal domain ComS PF17584.2 ETO20584.1 - 0.27 10.8 3.4 3.4 7.3 0.1 3.5 3 0 0 3 3 3 0 Bacillus competence protein S WD40 PF00400.32 ETO20585.1 - 3.8e-18 65.5 16.6 0.0053 17.6 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20585.1 - 1.8e-10 41.0 1.3 3.3 8.1 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO20585.1 - 2.8e-05 23.9 1.1 0.18 11.8 0.0 5.1 5 1 0 5 5 5 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO20585.1 - 0.00013 20.8 3.3 0.14 10.9 0.1 4.0 2 1 1 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 ETO20585.1 - 0.00019 20.9 1.7 0.047 13.0 0.2 3.4 2 1 2 4 4 4 2 WD40-like domain Me-amine-dh_H PF06433.11 ETO20585.1 - 0.0014 17.6 0.1 0.053 12.4 0.0 2.7 1 1 2 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 ETO20585.1 - 0.0069 16.0 0.1 0.18 11.3 0.0 2.2 2 0 0 2 2 2 1 PQQ-like domain Surfac_D-trimer PF09006.11 ETO20585.1 - 0.019 14.9 0.0 1.4 8.8 0.0 2.4 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation DPPIV_N PF00930.21 ETO20585.1 - 0.033 13.0 0.2 7.9 5.1 0.0 3.5 1 1 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Str_synth PF03088.16 ETO20585.1 - 0.034 14.3 1.1 18 5.5 0.0 4.2 2 1 3 5 5 5 0 Strictosidine synthase DUF5570 PF17731.1 ETO20585.1 - 0.054 13.6 0.6 3.2 7.8 0.0 3.2 1 1 2 4 4 4 0 Family of unknown function (DUF5570) Kelch_1 PF01344.25 ETO20586.1 - 4.5e-09 35.8 2.2 5.8e-06 25.8 0.5 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO20586.1 - 2.5e-06 27.6 3.2 0.0057 16.9 0.4 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO20586.1 - 0.00029 20.7 6.0 0.0033 17.4 1.2 3.8 5 0 0 5 5 5 1 Kelch motif Kelch_2 PF07646.15 ETO20586.1 - 0.0018 18.2 8.8 0.012 15.5 0.6 4.3 5 1 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO20586.1 - 0.0095 16.2 0.0 0.38 11.1 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO20586.1 - 0.018 15.1 0.1 0.081 12.9 0.1 2.2 1 0 0 1 1 1 0 Galactose oxidase, central domain WD40 PF00400.32 ETO20587.1 - 5.1e-40 134.7 22.2 5e-09 36.6 0.1 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20587.1 - 8.5e-14 51.6 3.8 0.0045 17.3 0.1 5.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20587.1 - 8.4e-06 24.7 3.4 0.81 8.3 0.0 4.2 1 1 3 4 4 4 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO20587.1 - 1.1e-05 24.5 0.8 5.9 5.8 0.1 4.6 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO20587.1 - 0.0058 16.0 2.8 0.94 8.7 0.0 4.0 3 1 3 6 6 6 1 WD40-like domain Bet_v_1 PF00407.19 ETO20587.1 - 0.065 13.1 2.0 8.5 6.3 0.2 3.3 2 2 2 4 4 4 0 Pathogenesis-related protein Bet v I family DUF2415 PF10313.9 ETO20587.1 - 0.067 13.1 0.0 0.63 10.0 0.0 2.5 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) NPV_P10 PF05531.12 ETO20588.1 - 0.0075 16.7 6.4 0.11 12.9 2.2 3.3 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein BAR_3 PF16746.5 ETO20588.1 - 0.014 15.1 2.9 0.014 15.1 2.9 2.1 2 0 0 2 2 2 0 BAR domain of APPL family BssS PF13991.6 ETO20588.1 - 0.12 12.4 0.5 0.42 10.7 0.1 2.1 2 0 0 2 2 2 0 BssS protein family SKA2 PF16740.5 ETO20588.1 - 0.13 12.0 8.5 0.12 12.2 5.9 2.3 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF948 PF06103.11 ETO20588.1 - 0.22 11.8 2.5 1.3 9.3 1.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TMF_TATA_bd PF12325.8 ETO20588.1 - 0.36 11.1 8.5 0.047 13.9 1.9 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.9 ETO20588.1 - 0.78 10.1 7.6 2.5 8.4 3.9 2.8 2 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 zf-C4pol PF14260.6 ETO20588.1 - 0.96 10.0 4.5 22 5.6 2.8 2.8 1 1 1 2 2 2 0 C4-type zinc-finger of DNA polymerase delta CNDH2_C PF16858.5 ETO20589.1 - 0.0032 17.4 6.9 0.0037 17.2 6.9 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term Interfer-bind PF09294.10 ETO20589.1 - 0.048 14.0 0.6 0.26 11.6 0.1 2.3 2 1 0 2 2 2 0 Interferon-alpha/beta receptor, fibronectin type III fn3 PF00041.21 ETO20589.1 - 0.057 13.8 0.0 0.13 12.7 0.0 1.7 1 0 0 1 1 1 0 Fibronectin type III domain NOA36 PF06524.12 ETO20589.1 - 0.12 11.6 12.4 0.18 11.1 12.4 1.3 1 0 0 1 1 1 0 NOA36 protein Fungal_TACC PF12709.7 ETO20589.1 - 0.37 11.3 5.4 0.36 11.3 3.1 2.1 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins NPR3 PF03666.13 ETO20589.1 - 8.4 5.1 10.9 11 4.7 10.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AATF-Che1 PF13339.6 ETO20591.1 - 5e-29 101.8 10.5 5e-29 101.8 10.5 4.0 2 2 2 4 4 4 1 Apoptosis antagonizing transcription factor TRAUB PF08164.12 ETO20591.1 - 9.4e-13 48.5 0.7 9.4e-13 48.5 0.7 3.9 4 1 0 4 4 4 1 Apoptosis-antagonizing transcription factor, C-terminal DUF769 PF05590.11 ETO20591.1 - 0.02 14.3 0.9 0.043 13.3 0.9 1.6 1 0 0 1 1 1 0 Xylella fastidiosa protein of unknown function (DUF769) SseC PF04888.12 ETO20591.1 - 0.17 11.4 0.0 0.17 11.4 0.0 2.0 3 0 0 3 3 3 0 Secretion system effector C (SseC) like family DUF758 PF05527.11 ETO20592.1 - 0.15 12.0 3.5 7.8 6.4 0.7 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF758) AAA_8 PF12780.7 ETO20593.1 - 1e-64 218.4 0.3 4.5e-64 216.3 0.3 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 Kelch_4 PF13418.6 ETO20594.1 - 0.011 15.8 1.5 0.36 10.9 0.1 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain OTT_1508_deam PF14441.6 ETO20595.1 - 0.022 14.8 2.3 3.8 7.6 0.2 2.5 2 0 0 2 2 2 0 OTT_1508-like deaminase Mce4_CUP1 PF11887.8 ETO20596.1 - 0.0089 15.5 0.4 0.015 14.8 0.4 1.3 1 0 0 1 1 1 1 Cholesterol uptake porter CUP1 of Mce4, putative CDC45 PF02724.14 ETO20596.1 - 0.039 12.3 9.4 0.048 11.9 9.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO20596.1 - 0.069 11.9 11.4 0.1 11.4 11.4 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO20596.1 - 0.08 12.8 11.8 0.13 12.1 11.8 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CobT PF06213.12 ETO20596.1 - 0.087 12.2 19.1 0.15 11.5 19.1 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4746 PF15928.5 ETO20596.1 - 0.095 12.1 11.5 0.14 11.6 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CCSAP PF15748.5 ETO20596.1 - 0.16 12.1 15.5 0.28 11.3 15.5 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Roughex PF06020.11 ETO20596.1 - 0.36 9.9 11.0 0.53 9.3 11.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein ESM4 PF15952.5 ETO20596.1 - 0.37 11.2 15.7 0.15 12.5 12.6 1.8 2 0 0 2 2 2 0 Enhancer of split M4 family Tim54 PF11711.8 ETO20596.1 - 0.48 9.2 12.2 0.82 8.4 12.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Connexin PF00029.19 ETO20596.1 - 0.48 10.1 5.0 0.72 9.6 5.0 1.4 1 0 0 1 1 1 0 Connexin PBP_sp32 PF07222.12 ETO20596.1 - 0.54 9.7 16.6 0.97 8.8 16.6 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 NOA36 PF06524.12 ETO20596.1 - 0.58 9.4 10.1 0.84 8.9 10.1 1.2 1 0 0 1 1 1 0 NOA36 protein AI-2E_transport PF01594.16 ETO20596.1 - 0.59 9.2 2.2 0.85 8.7 2.2 1.2 1 0 0 1 1 1 0 AI-2E family transporter CLN3 PF02487.17 ETO20596.1 - 0.65 9.0 5.4 1 8.3 5.4 1.4 1 0 0 1 1 1 0 CLN3 protein Serinc PF03348.15 ETO20596.1 - 0.68 8.8 6.0 0.94 8.3 6.0 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ferlin_C PF16165.5 ETO20596.1 - 1.1 9.1 5.3 2.5 8.0 5.3 1.6 1 0 0 1 1 1 0 Ferlin C-terminus DDHD PF02862.17 ETO20596.1 - 1.4 9.0 19.4 2.6 8.1 19.4 1.6 1 1 0 1 1 1 0 DDHD domain Sec62 PF03839.16 ETO20596.1 - 1.4 8.3 5.6 2.1 7.8 5.6 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 CSG2 PF16965.5 ETO20596.1 - 2.5 6.9 9.7 4.4 6.1 9.7 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator TT_ORF1 PF02956.14 ETO20596.1 - 2.8 6.5 11.6 3.6 6.2 11.6 1.1 1 0 0 1 1 1 0 TT viral orf 1 SMYLE_N PF18615.1 ETO20596.1 - 2.9 7.4 14.5 0.64 9.5 11.1 1.5 2 0 0 2 2 2 0 Short myomegalin-like EB1 binding proteins, N-terminal domain RNA_pol_3_Rpc31 PF11705.8 ETO20596.1 - 3.1 8.0 18.9 5.4 7.2 18.9 1.5 1 1 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Zip PF02535.22 ETO20596.1 - 6 6.0 7.2 9.5 5.3 7.2 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CAC1F_C PF16885.5 ETO20596.1 - 6.2 6.4 17.0 6.5 6.3 16.1 1.4 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term TCP PF03634.13 ETO20596.1 - 6.3 7.3 20.0 1.4 9.5 16.6 1.6 2 0 0 2 2 2 0 TCP family transcription factor E1_dh PF00676.20 ETO20597.1 - 2.5e-11 43.1 0.0 3.3e-11 42.7 0.0 1.1 1 0 0 1 1 1 1 Dehydrogenase E1 component DNA_meth_N PF18284.1 ETO20597.1 - 0.11 12.5 0.1 0.38 10.7 0.1 1.9 1 0 0 1 1 1 0 DNA methylase N-terminal domain DUF3911 PF13050.6 ETO20598.1 - 0.11 12.6 0.2 19 5.5 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3911) RskA PF10099.9 ETO20599.1 - 0.007 16.7 4.8 0.012 15.9 4.8 1.3 1 0 0 1 1 1 1 Anti-sigma-K factor rskA KAR9 PF08580.10 ETO20599.1 - 1.3 7.5 7.9 1.6 7.2 7.9 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 DUF2826 PF11442.8 ETO20600.1 - 0.061 13.2 0.1 0.074 12.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2826) SKN1 PF03935.15 ETO20601.1 - 0.028 12.8 0.0 0.044 12.2 0.0 1.2 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) cNMP_binding PF00027.29 ETO20602.1 - 1.3e-33 114.9 0.0 5.5e-16 58.4 0.0 2.7 2 1 0 2 2 2 2 Cyclic nucleotide-binding domain B PF02216.16 ETO20602.1 - 0.51 10.4 2.3 31 4.6 0.1 3.5 2 1 1 3 3 3 0 B domain Apolipoprotein PF01442.18 ETO20603.1 - 0.0088 15.9 0.9 0.015 15.2 0.9 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain EssA PF10661.9 ETO20603.1 - 0.01 15.7 5.0 0.013 15.3 5.0 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA Med9 PF07544.13 ETO20603.1 - 0.032 14.3 9.3 2.6 8.2 0.1 3.0 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 DUF2175 PF09943.9 ETO20603.1 - 0.23 11.7 4.1 0.17 12.2 0.7 2.0 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) IL11 PF07400.11 ETO20603.1 - 1.2 8.7 8.4 4.4 6.9 6.1 2.1 1 1 1 2 2 2 0 Interleukin 11 XhlA PF10779.9 ETO20603.1 - 2.3 8.5 8.7 0.65 10.2 2.7 2.7 3 0 0 3 3 3 0 Haemolysin XhlA GTP_EFTU PF00009.27 ETO20604.1 - 7.5e-29 100.7 5.4 6e-27 94.4 5.4 2.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO20604.1 - 1e-08 35.2 0.5 5.3e-08 32.9 0.1 2.3 2 0 0 2 2 2 1 50S ribosome-binding GTPase IF-2 PF11987.8 ETO20604.1 - 1.5e-08 34.7 0.4 4.8e-08 33.1 0.0 2.0 2 0 0 2 2 2 1 Translation-initiation factor 2 Roc PF08477.13 ETO20604.1 - 0.00028 21.1 3.5 0.0013 18.9 0.0 3.1 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO20604.1 - 0.0015 18.2 0.1 0.0044 16.6 0.1 1.8 1 0 0 1 1 1 1 Ras family FeoB_N PF02421.18 ETO20604.1 - 0.0045 16.5 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ETO20604.1 - 0.0076 15.7 1.8 0.014 14.8 0.1 2.3 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1_Xtn PF16897.5 ETO20604.1 - 0.012 15.6 0.3 3.1 7.9 0.1 2.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain GSK-3_bind PF05350.12 ETO20604.1 - 0.068 12.5 0.3 7.5 5.8 0.2 2.5 2 0 0 2 2 2 0 Glycogen synthase kinase-3 binding DUF3246 PF11596.8 ETO20604.1 - 2.5 7.5 6.1 7.6 5.9 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) WD40 PF00400.32 ETO20605.1 - 3.7e-09 37.1 10.8 0.00088 20.1 0.1 4.5 4 1 1 5 5 5 2 WD domain, G-beta repeat Pkinase PF00069.25 ETO20606.1 - 1.2e-71 241.1 0.5 1.7e-71 240.7 0.5 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20606.1 - 3.9e-35 121.4 0.2 5.5e-35 120.9 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH PF00169.29 ETO20606.1 - 8.1e-06 26.3 0.3 2.3e-05 24.8 0.3 1.9 1 0 0 1 1 1 1 PH domain APH PF01636.23 ETO20606.1 - 0.00012 22.0 0.0 0.00085 19.3 0.0 2.0 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO20606.1 - 0.0011 17.8 0.0 0.003 16.4 0.0 1.6 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO20606.1 - 0.0086 15.4 0.2 0.36 10.1 0.0 2.3 1 1 0 2 2 2 1 Kinase-like Kdo PF06293.14 ETO20606.1 - 0.011 15.1 0.1 0.023 14.0 0.1 1.5 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO20606.1 - 0.023 14.2 0.2 0.099 12.1 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Nudix_N_2 PF14803.6 ETO20606.1 - 0.12 12.3 0.7 1.2 9.1 0.1 2.5 2 0 0 2 2 2 0 Nudix N-terminal FTA2 PF13095.6 ETO20606.1 - 0.13 11.8 2.6 0.27 10.8 0.0 2.3 2 1 0 3 3 3 0 Kinetochore Sim4 complex subunit FTA2 TAN PF11640.8 ETO20607.1 - 0.0059 16.7 1.4 0.0071 16.5 1.4 1.2 1 0 0 1 1 1 1 Telomere-length maintenance and DNA damage repair Lipoprotein_2 PF00921.17 ETO20607.1 - 0.023 14.3 1.3 0.025 14.2 1.3 1.0 1 0 0 1 1 1 0 Borrelia lipoprotein SKA2 PF16740.5 ETO20607.1 - 0.085 12.6 7.6 0.36 10.6 4.2 2.2 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 HemX PF04375.14 ETO20607.1 - 0.11 11.8 5.5 0.12 11.6 5.5 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase YolD PF08863.10 ETO20607.1 - 0.16 12.1 8.4 0.053 13.6 4.7 2.1 2 1 1 3 3 3 0 YolD-like protein FapA PF03961.13 ETO20607.1 - 0.18 10.4 8.2 0.21 10.2 8.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A COG2 PF06148.11 ETO20607.1 - 0.42 10.7 6.9 4.7 7.3 0.2 2.1 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 PRKG1_interact PF15898.5 ETO20607.1 - 0.65 10.9 11.1 1.4 9.8 11.1 1.5 1 1 0 1 1 1 0 cGMP-dependent protein kinase interacting domain Spc24 PF08286.11 ETO20607.1 - 1.4 9.2 7.9 6.5 7.1 7.9 1.9 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Afi1 PF07792.12 ETO20609.1 - 0.01 16.3 3.2 0.01 16.3 3.2 2.3 1 1 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4136 PF13590.6 ETO20609.1 - 0.042 14.4 4.0 0.46 11.1 3.3 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4136) DUF3915 PF13054.6 ETO20609.1 - 0.074 13.0 2.2 0.18 11.8 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Serinc PF03348.15 ETO20609.1 - 1.6 7.6 6.5 1.4 7.8 5.4 1.4 1 1 1 2 2 2 0 Serine incorporator (Serinc) DUF826 PF05696.11 ETO20609.1 - 3.3 7.9 7.3 1.7 8.8 0.6 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF826) Terminase_2 PF03592.16 ETO20609.1 - 4.3 7.8 10.5 1.5 9.3 3.1 2.5 1 1 1 2 2 2 0 Terminase small subunit Atrophin-1 PF03154.15 ETO20609.1 - 4.8 5.3 7.7 7.4 4.7 7.7 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF4746 PF15928.5 ETO20609.1 - 7.1 6.0 11.5 0.066 12.6 1.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) WD40 PF00400.32 ETO20610.1 - 1.5e-36 123.7 32.5 1.8e-06 28.6 1.2 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20610.1 - 7.1e-12 45.5 4.1 0.025 14.9 0.0 6.2 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20610.1 - 2e-08 33.4 11.7 0.0033 16.2 1.1 5.5 2 2 3 5 5 5 5 Nucleoporin Nup120/160 AI-2E_transport PF01594.16 ETO20610.1 - 0.21 10.7 1.7 0.33 10.1 1.7 1.2 1 0 0 1 1 1 0 AI-2E family transporter Ac76 PF05814.11 ETO20611.1 - 0.8 9.8 0.0 0.8 9.8 0.0 2.6 3 0 0 3 3 3 0 Orf76 (Ac76) TetR PF13972.6 ETO20612.1 - 0.01 15.5 3.6 0.058 13.1 3.6 2.2 1 1 0 1 1 1 0 Bacterial transcriptional repressor TMF_TATA_bd PF12325.8 ETO20612.1 - 0.028 14.7 5.6 0.028 14.7 5.6 4.8 4 1 1 5 5 5 0 TATA element modulatory factor 1 TATA binding IFS PF16718.5 ETO20612.1 - 0.028 14.5 1.4 0.028 14.5 1.4 2.8 2 1 0 2 2 2 0 Immunity factor for SPN DUF2721 PF11026.8 ETO20612.1 - 0.13 12.1 4.6 1.4 8.8 0.5 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) MbeD_MobD PF04899.12 ETO20612.1 - 0.14 12.3 6.1 0.4 10.8 6.1 1.8 1 0 0 1 1 1 0 MbeD/MobD like RPOL_N PF14700.6 ETO20612.1 - 0.55 9.6 21.0 0.084 12.2 8.2 3.1 3 0 0 3 3 3 0 DNA-directed RNA polymerase N-terminal DUF4199 PF13858.6 ETO20612.1 - 0.68 10.3 0.0 0.68 10.3 0.0 3.8 4 0 0 4 4 4 0 Protein of unknown function (DUF4199) Ferric_reduct PF01794.19 ETO20614.1 - 4.7e-05 23.5 9.6 4.7e-05 23.5 9.6 2.6 2 1 0 2 2 2 1 Ferric reductase like transmembrane component Apis_Csd PF11671.8 ETO20614.1 - 0.018 15.0 7.0 0.03 14.3 7.0 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein LRR19-TM PF15176.6 ETO20614.1 - 6.5 6.8 7.4 23 5.1 1.2 3.0 2 1 0 2 2 2 0 Leucine-rich repeat family 19 TM domain SDA1 PF05285.12 ETO20615.1 - 9.2 5.6 9.9 9.1 5.6 9.9 1.0 1 0 0 1 1 1 0 SDA1 DUF2981 PF11200.8 ETO20616.1 - 0.35 10.6 7.6 0.5 10.1 7.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Neur_chan_memb PF02932.16 ETO20616.1 - 0.9 9.5 7.2 1.7 8.7 7.2 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3807 PF12720.7 ETO20616.1 - 2.5 8.3 20.3 1.4 9.2 17.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) GEMIN8 PF15348.6 ETO20617.1 - 0.00029 21.2 0.5 0.00029 21.2 0.5 2.4 2 1 1 3 3 3 1 Gemini of Cajal bodies-associated protein 8 CitG PF01874.16 ETO20617.1 - 0.13 11.9 1.1 0.31 10.6 1.1 1.6 1 1 0 1 1 1 0 ATP:dephospho-CoA triphosphoribosyl transferase RabGAP-TBC PF00566.18 ETO20618.1 - 1.2e-09 38.2 11.5 1.2e-09 38.2 11.5 3.9 3 1 0 3 3 3 1 Rab-GTPase-TBC domain PH PF00169.29 ETO20618.1 - 0.00032 21.2 0.1 0.00032 21.2 0.1 3.9 6 0 0 6 6 6 1 PH domain tRNA-synt_2 PF00152.20 ETO20619.1 - 5.8e-38 130.7 0.0 9.3e-38 130.1 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ETO20619.1 - 1.1e-10 41.3 0.3 2.3e-10 40.3 0.1 1.7 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain tRNA-synt_2d PF01409.20 ETO20619.1 - 0.0028 17.2 0.0 0.0096 15.4 0.0 1.7 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) tRNA-synt_2 PF00152.20 ETO20620.1 - 4.6e-16 58.8 0.0 5.4e-16 58.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) Abhydrolase_3 PF07859.13 ETO20621.1 - 2.1e-12 47.3 0.0 2.7e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETO20621.1 - 3.4e-05 22.9 0.1 4.3e-05 22.6 0.1 1.2 1 0 0 1 1 1 1 Steryl acetyl hydrolase Yip1 PF04893.17 ETO20622.1 - 3.3 7.4 14.8 19 4.9 8.8 3.0 2 1 0 2 2 2 0 Yip1 domain MgtE PF01769.16 ETO20622.1 - 5.8 7.3 8.8 5.3 7.5 1.9 2.3 2 0 0 2 2 2 0 Divalent cation transporter Sec3-PIP2_bind PF15277.6 ETO20624.1 - 0.013 15.7 0.6 9.7 6.4 0.1 3.3 3 0 0 3 3 3 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH Vps39_2 PF10367.9 ETO20625.1 - 3.9e-15 56.2 0.3 7.7e-12 45.6 0.0 3.3 3 0 0 3 3 3 2 Vacuolar sorting protein 39 domain 2 Clathrin PF00637.20 ETO20625.1 - 2.4e-05 24.3 11.4 0.00011 22.1 2.4 4.4 3 2 0 3 3 3 1 Region in Clathrin and VPS Vps39_1 PF10366.9 ETO20625.1 - 0.00011 22.5 7.1 0.0093 16.2 0.1 4.1 2 1 1 3 3 3 2 Vacuolar sorting protein 39 domain 1 JHD PF17811.1 ETO20625.1 - 0.058 13.9 0.6 0.78 10.3 0.1 2.6 2 0 0 2 2 2 0 Jumonji helical domain CAP_C PF08603.11 ETO20626.1 - 9e-16 57.9 16.2 8.1e-14 51.5 10.7 2.4 2 1 0 2 2 2 2 Adenylate cyclase associated (CAP) C terminal Wzy_C PF04932.15 ETO20626.1 - 0.046 13.4 0.3 0.058 13.0 0.3 1.1 1 0 0 1 1 1 0 O-Antigen ligase DUF2556 PF10831.8 ETO20626.1 - 0.077 12.9 1.0 0.19 11.7 1.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2556) DUF3923 PF13061.6 ETO20626.1 - 0.8 9.8 6.7 1.2 9.3 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3923) DUF1840 PF08895.11 ETO20629.1 - 1.1 9.7 3.5 0.74 10.2 1.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Tmemb_cc2 PF10267.9 ETO20629.1 - 1.6 7.8 5.9 2.2 7.3 5.9 1.2 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Peptidase_Mx PF15887.5 ETO20630.1 - 0.0013 18.2 0.1 0.0016 17.9 0.1 1.1 1 0 0 1 1 1 1 Putative zinc-binding metallo-peptidase MMM1 PF10296.9 ETO20631.1 - 0.028 13.5 1.7 0.061 12.4 1.7 1.6 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 UPF0242 PF06785.11 ETO20632.1 - 0.13 12.4 40.7 0.032 14.3 25.1 2.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PilJ PF13675.6 ETO20632.1 - 0.17 11.9 1.0 0.39 10.7 1.0 1.6 1 1 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term OsmC PF02566.19 ETO20632.1 - 0.45 11.0 3.7 2.1 8.9 0.9 2.7 2 0 0 2 2 2 0 OsmC-like protein DUF5082 PF16888.5 ETO20632.1 - 7.2 6.9 33.1 0.37 11.1 9.0 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) TolA_bind_tri PF16331.5 ETO20632.1 - 7.5 6.7 18.7 1.4 9.0 6.5 2.8 2 0 0 2 2 2 0 TolA binding protein trimerisation DUF641 PF04859.12 ETO20632.1 - 7.6 6.9 19.8 0.048 14.0 5.4 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Pox_A_type_inc PF04508.12 ETO20633.1 - 0.025 14.4 0.6 0.19 11.6 0.1 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat PKcGMP_CC PF16808.5 ETO20633.1 - 0.065 13.1 13.9 0.59 10.0 0.3 3.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase WHEP-TRS PF00458.20 ETO20633.1 - 2.4 8.4 11.3 3.1 8.0 7.6 2.7 2 0 0 2 2 2 0 WHEP-TRS domain DUF4407 PF14362.6 ETO20633.1 - 4.2 6.6 17.2 7.9 5.7 17.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ras PF00071.22 ETO20634.1 - 1e-21 77.2 0.1 1.6e-21 76.6 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO20634.1 - 1.4e-07 31.8 0.0 3.6e-07 30.4 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO20634.1 - 1.7e-06 27.6 0.1 2.7e-06 27.0 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO20634.1 - 0.0017 17.7 0.1 0.0028 17.0 0.1 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO20634.1 - 0.0041 16.7 0.1 0.0071 15.9 0.1 1.4 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO20634.1 - 0.11 12.3 0.3 0.22 11.4 0.3 1.4 1 1 0 1 1 1 0 RsgA GTPase Ribo_biogen_C PF04034.13 ETO20635.1 - 4.2e-35 120.3 0.0 7.4e-35 119.5 0.0 1.4 1 0 0 1 1 1 1 Ribosome biogenesis protein, C-terminal RLI PF04068.15 ETO20635.1 - 1.6e-12 47.0 0.1 3e-12 46.1 0.1 1.5 1 0 0 1 1 1 1 Possible Fer4-like domain in RNase L inhibitor, RLI DUF4228 PF14009.6 ETO20635.1 - 0.0098 16.3 0.7 0.0098 16.3 0.7 2.8 2 1 0 2 2 2 1 Domain of unknown function (DUF4228) Ras PF00071.22 ETO20636.1 - 1.9e-06 27.5 0.0 3.9e-06 26.6 0.0 1.5 1 1 0 1 1 1 1 Ras family SARAF PF06682.12 ETO20637.1 - 0.71 9.5 8.4 0.69 9.5 5.6 2.2 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Tropomyosin_1 PF12718.7 ETO20638.1 - 0.0044 17.2 5.9 0.0044 17.2 5.9 2.9 2 1 0 2 2 2 1 Tropomyosin like Lzipper-MIP1 PF14389.6 ETO20638.1 - 0.0087 16.3 1.2 0.0087 16.3 1.2 2.6 3 0 0 3 3 3 1 Leucine-zipper of ternary complex factor MIP1 Jnk-SapK_ap_N PF09744.9 ETO20638.1 - 0.17 12.1 13.1 0.099 12.9 8.1 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 WDCP PF15390.6 ETO20638.1 - 0.39 9.1 6.7 0.48 8.8 6.7 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Cnn_1N PF07989.11 ETO20638.1 - 0.86 9.8 14.3 16 5.7 0.2 3.0 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 UPF0242 PF06785.11 ETO20638.1 - 1.5 8.9 18.4 21 5.2 18.4 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus CENP-F_leu_zip PF10473.9 ETO20638.1 - 1.5 8.8 17.6 0.16 12.0 11.0 2.1 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CHD5 PF04420.14 ETO20638.1 - 6.2 6.7 13.9 0.54 10.1 0.2 2.5 2 1 0 2 2 2 0 CHD5-like protein DUF3450 PF11932.8 ETO20638.1 - 9.1 5.5 11.5 1.8 7.8 7.0 2.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) Leu_zip PF15294.6 ETO20640.1 - 0.0095 15.5 4.7 0.011 15.3 4.7 1.1 1 0 0 1 1 1 1 Leucine zipper EBP50_C PF09007.11 ETO20640.1 - 0.019 15.9 0.7 0.03 15.3 0.2 1.5 2 0 0 2 2 2 0 EBP50, C-terminal Atg14 PF10186.9 ETO20640.1 - 0.027 13.6 4.3 0.028 13.5 4.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 FSAP_sig_propep PF03032.15 ETO20640.1 - 1.6 8.8 0.1 1.6 8.8 0.1 2.6 2 1 0 2 2 2 0 Frog skin active peptide family signal and propeptide DUF4833 PF16117.5 ETO20641.1 - 1.8e-45 154.3 0.1 3.2e-45 153.5 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4833) NS3_envE PF02723.14 ETO20641.1 - 0.051 13.7 0.1 0.098 12.7 0.1 1.4 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E Dynein_light PF01221.18 ETO20642.1 - 5.2e-18 65.1 2.6 5.2e-18 65.1 2.6 2.2 1 1 1 2 2 2 1 Dynein light chain type 1 Cytochrom_B561 PF03188.16 ETO20642.1 - 0.042 14.0 1.8 0.12 12.5 0.5 2.0 1 1 1 2 2 2 0 Eukaryotic cytochrome b561 DUF4834 PF16118.5 ETO20643.1 - 3e-05 24.9 0.6 3e-05 24.9 0.6 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4834) CDC45 PF02724.14 ETO20643.1 - 0.001 17.5 17.5 0.0013 17.1 17.5 1.0 1 0 0 1 1 1 1 CDC45-like protein V_ATPase_I PF01496.19 ETO20643.1 - 0.0013 16.8 1.2 0.0013 16.8 1.2 1.9 1 1 1 2 2 2 1 V-type ATPase 116kDa subunit family SARAF PF06682.12 ETO20643.1 - 0.0021 17.8 0.0 0.0025 17.5 0.0 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis Neur_chan_memb PF02932.16 ETO20643.1 - 0.0067 16.5 2.9 0.0082 16.2 2.9 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 ETO20643.1 - 0.007 14.8 4.5 0.0095 14.4 4.5 1.4 1 1 0 1 1 1 1 dsRNA-gated channel SID-1 Glucodextran_N PF09137.11 ETO20643.1 - 0.01 15.4 0.3 0.014 15.0 0.3 1.1 1 0 0 1 1 1 0 Glucodextranase, domain N Nop14 PF04147.12 ETO20643.1 - 0.028 12.7 15.5 0.032 12.5 15.5 1.1 1 0 0 1 1 1 0 Nop14-like family CBP_BcsG PF11658.8 ETO20643.1 - 0.03 12.8 0.7 0.055 11.9 0.0 1.7 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsG TRAP_alpha PF03896.16 ETO20643.1 - 0.081 12.1 9.5 0.061 12.5 8.1 1.4 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit EphA2_TM PF14575.6 ETO20643.1 - 0.083 13.8 3.3 0.45 11.4 3.3 2.2 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DNA_pol_phi PF04931.13 ETO20643.1 - 0.17 9.9 14.9 0.2 9.7 14.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi Tetraspanin PF00335.20 ETO20643.1 - 0.19 11.4 1.1 0.33 10.6 1.1 1.7 1 1 0 1 1 1 0 Tetraspanin family MAPEG PF01124.18 ETO20643.1 - 0.21 11.5 0.1 0.36 10.8 0.1 1.6 1 1 0 1 1 1 0 MAPEG family FAM176 PF14851.6 ETO20643.1 - 0.28 10.8 15.2 27 4.4 15.2 2.8 1 1 0 1 1 1 0 FAM176 family SpoIIIAH PF12685.7 ETO20643.1 - 0.38 10.6 11.2 0.67 9.7 11.2 1.4 1 1 0 1 1 1 0 SpoIIIAH-like protein DUF4446 PF14584.6 ETO20643.1 - 0.81 9.7 10.3 0.12 12.4 2.7 2.3 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) Serinc PF03348.15 ETO20643.1 - 1.1 8.1 7.5 0.053 12.5 1.1 1.8 1 1 1 2 2 2 0 Serine incorporator (Serinc) Connexin PF00029.19 ETO20643.1 - 1.1 9.0 8.7 16 5.1 8.7 2.0 1 1 0 1 1 1 0 Connexin Folate_carrier PF01770.18 ETO20643.1 - 1.4 7.6 5.3 0.68 8.6 0.0 2.0 1 1 1 2 2 2 0 Reduced folate carrier CLN3 PF02487.17 ETO20643.1 - 1.7 7.6 6.2 9.9 5.1 6.2 1.9 1 1 0 1 1 1 0 CLN3 protein Zip PF02535.22 ETO20643.1 - 1.9 7.6 11.1 3.2 6.9 11.1 1.4 1 1 0 1 1 1 0 ZIP Zinc transporter O-antigen_lig PF13425.6 ETO20643.1 - 2 7.1 9.9 3.4 6.3 9.8 1.4 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Sigma_reg_N PF13800.6 ETO20643.1 - 3.3 8.1 9.7 3 8.2 7.6 2.0 2 1 1 3 3 3 0 Sigma factor regulator N-terminal Tmemb_9 PF05434.11 ETO20643.1 - 4.1 7.3 14.8 4.4 7.2 11.8 2.4 1 1 1 2 2 2 0 TMEM9 DUF3899 PF13038.6 ETO20643.1 - 5.8 7.5 7.7 46 4.6 7.7 2.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3899) RNase_PH PF01138.21 ETO20644.1 - 5.6e-08 33.4 0.2 2e-06 28.3 0.0 2.7 2 1 0 2 2 2 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ETO20644.1 - 0.0015 18.5 0.0 0.0039 17.2 0.0 1.7 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 BSP_II PF05432.11 ETO20644.1 - 2.3 7.8 14.4 0.028 14.1 6.6 1.6 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) RTC PF01137.21 ETO20645.1 - 3.7e-42 144.0 0.0 6e-20 71.4 0.0 2.1 2 0 0 2 2 2 2 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ETO20645.1 - 1.8e-14 54.1 0.2 4.4e-13 49.6 0.2 2.3 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain PHP PF02811.19 ETO20645.1 - 0.026 14.8 0.5 0.045 14.1 0.2 1.6 2 0 0 2 2 2 0 PHP domain Pox_EPC_I2-L1 PF12575.8 ETO20645.1 - 0.11 12.7 0.9 5.3 7.3 0.1 2.4 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Phospholamban PF04272.14 ETO20645.1 - 1 8.9 6.3 1.8 8.1 0.3 3.5 4 0 0 4 4 4 0 Phospholamban WD40 PF00400.32 ETO20646.1 - 6e-74 242.1 13.9 3e-10 40.5 0.1 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO20646.1 - 5.1e-24 84.8 1.6 0.016 14.2 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO20646.1 - 4.8e-23 81.3 1.0 0.0005 20.3 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO20646.1 - 1.6e-10 40.8 0.4 0.0055 16.1 0.0 3.9 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO20646.1 - 2.1e-10 39.9 7.1 0.56 8.8 0.0 6.4 1 1 5 7 7 7 5 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO20646.1 - 6.5e-08 31.5 1.7 0.0043 15.6 0.2 3.0 1 1 3 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO20646.1 - 6.7e-08 32.3 6.6 3.7 7.6 0.1 6.4 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO20646.1 - 2.3e-07 30.8 2.4 0.66 10.0 0.2 5.3 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 ETO20646.1 - 7.1e-06 25.6 1.5 1.3 8.3 0.0 4.8 2 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO20646.1 - 2.4e-05 23.6 1.3 0.097 11.7 0.5 3.0 1 1 2 3 3 3 2 Coatomer WD associated region DUF4072 PF13284.6 ETO20646.1 - 0.0032 17.9 0.0 19 5.8 0.0 4.8 6 0 0 6 6 6 0 Domain of unknown function (DUF4072) HARP PF07443.13 ETO20646.1 - 0.0036 16.9 0.3 0.34 10.6 0.1 3.6 3 0 0 3 3 3 1 HepA-related protein (HARP) Nucleoporin_N PF08801.11 ETO20646.1 - 0.0083 14.9 8.7 0.16 10.7 1.6 4.3 1 1 3 5 5 5 2 Nup133 N terminal like DPPIV_N PF00930.21 ETO20646.1 - 0.01 14.7 0.5 2.1 7.0 0.1 3.5 2 2 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Coat_X PF07552.11 ETO20646.1 - 0.13 12.1 0.1 0.61 10.0 0.0 2.2 2 0 0 2 2 2 0 Spore Coat Protein X and V domain Kelch_6 PF13964.6 ETO20647.1 - 4e-06 26.9 2.9 0.21 11.9 0.1 4.0 3 1 1 4 4 4 2 Kelch motif NAD_binding_1 PF00175.21 ETO20647.1 - 0.0018 18.9 0.8 0.0089 16.7 0.0 2.5 3 0 0 3 3 3 1 Oxidoreductase NAD-binding domain Kelch_1 PF01344.25 ETO20647.1 - 0.004 16.7 4.2 12 5.6 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO20647.1 - 0.039 14.0 0.3 2.6 8.1 0.0 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain NifU PF01106.17 ETO20647.1 - 0.094 12.9 0.1 0.27 11.4 0.1 1.8 1 0 0 1 1 1 0 NifU-like domain Kelch_5 PF13854.6 ETO20647.1 - 0.44 10.6 7.2 32 4.7 1.4 3.9 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO20648.1 - 6.1e-57 188.3 25.8 1.3e-10 41.7 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20648.1 - 1.2e-24 86.4 2.1 7.9e-05 22.9 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO20648.1 - 3.4e-10 39.7 0.7 1.5e-05 24.5 0.3 3.0 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO20648.1 - 1.5e-09 37.6 2.8 4.4 7.4 0.0 6.2 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO20648.1 - 1.3e-07 31.1 1.8 2.8e-05 23.3 0.2 2.5 1 1 1 2 2 2 2 Coatomer WD associated region Nup160 PF11715.8 ETO20648.1 - 1.9e-07 30.1 4.8 0.15 10.7 0.2 4.8 2 1 3 5 5 5 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO20648.1 - 2.1e-06 26.9 3.8 0.48 9.3 0.0 5.0 1 1 1 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO20648.1 - 1.4e-05 23.8 0.3 0.33 9.4 0.0 2.9 1 1 2 3 3 3 3 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO20648.1 - 2.9e-05 23.0 0.1 0.035 12.8 0.0 3.7 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_2 PF13360.6 ETO20648.1 - 4.3e-05 23.2 0.5 0.0021 17.7 0.1 2.6 1 1 1 2 2 2 2 PQQ-like domain Nbas_N PF15492.6 ETO20648.1 - 0.0006 19.2 5.2 0.18 11.1 0.0 4.3 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Frtz PF11768.8 ETO20648.1 - 0.0007 18.0 0.2 1.3 7.3 0.0 2.6 1 1 1 3 3 3 2 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 ETO20648.1 - 0.00082 18.5 0.0 0.0031 16.6 0.0 2.1 1 1 0 1 1 1 1 VID27 C-terminal WD40-like domain Lactonase PF10282.9 ETO20648.1 - 0.0014 18.0 0.1 0.0064 15.8 0.0 2.1 2 1 0 2 2 2 1 Lactonase, 7-bladed beta-propeller PALB2_WD40 PF16756.5 ETO20648.1 - 0.0016 17.5 3.0 0.22 10.4 0.1 3.3 1 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain APS-reductase_C PF12139.8 ETO20648.1 - 0.004 17.3 1.9 4.5 7.6 0.0 4.2 5 0 0 5 5 5 1 Adenosine-5'-phosphosulfate reductase beta subunit NHL PF01436.21 ETO20648.1 - 0.0051 16.8 0.2 5.4 7.2 0.1 3.9 4 0 0 4 4 4 1 NHL repeat DUF5570 PF17731.1 ETO20648.1 - 0.0069 16.5 1.9 14 5.8 0.0 4.7 2 1 4 6 6 6 0 Family of unknown function (DUF5570) DUF2415 PF10313.9 ETO20648.1 - 0.02 14.8 0.1 9.1 6.3 0.0 3.9 4 0 0 4 4 4 0 Uncharacterised protein domain (DUF2415) Str_synth PF03088.16 ETO20648.1 - 0.021 15.0 0.5 12 6.1 0.0 4.3 4 1 1 5 5 5 0 Strictosidine synthase DUF5046 PF16465.5 ETO20648.1 - 0.064 12.7 0.0 1.2 8.5 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) Exostosin PF03016.15 ETO20650.1 - 1.8e-22 79.9 0.2 7.8e-22 77.8 0.2 2.0 1 1 0 1 1 1 1 Exostosin family tRNA-synt_His PF13393.6 ETO20651.1 - 1.9e-23 83.2 0.1 3.5e-23 82.4 0.1 1.4 1 1 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ETO20651.1 - 0.00034 20.7 0.0 0.00078 19.6 0.0 1.6 1 0 0 1 1 1 1 Anticodon binding domain GPP34 PF05719.11 ETO20651.1 - 0.15 12.1 0.0 0.28 11.2 0.0 1.4 1 0 0 1 1 1 0 Golgi phosphoprotein 3 (GPP34) DUF4291 PF14124.6 ETO20652.1 - 0.0005 20.0 1.3 0.0006 19.7 1.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4291) USP7_C2 PF14533.6 ETO20652.1 - 0.0046 16.7 1.0 0.0056 16.4 1.0 1.2 1 0 0 1 1 1 1 Ubiquitin-specific protease C-terminal LUD_dom PF02589.15 ETO20652.1 - 0.052 13.3 0.0 0.063 13.0 0.0 1.1 1 0 0 1 1 1 0 LUD domain DUF2951 PF11166.8 ETO20653.1 - 0.14 12.3 10.8 0.24 11.6 0.3 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF2951) DUF553 PF04473.12 ETO20654.1 - 0.0049 16.4 0.5 0.0075 15.8 0.5 1.2 1 0 0 1 1 1 1 Transglutaminase-like domain DUF3135 PF11333.8 ETO20655.1 - 4.3e-05 23.7 12.9 0.019 15.2 1.8 4.5 3 1 1 4 4 4 3 Protein of unknown function (DUF3135) Merozoite_SPAM PF07133.11 ETO20656.1 - 1.6 8.7 32.6 2 8.4 32.6 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DNA_pol_phi PF04931.13 ETO20656.1 - 2.3 6.2 19.7 2.3 6.2 19.7 1.0 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO20656.1 - 9.4 4.3 17.0 9.2 4.3 17.0 1.0 1 0 0 1 1 1 0 Nop14-like family Ribosomal_60s PF00428.19 ETO20658.1 - 0.52 10.9 7.4 6.2 7.5 6.3 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein NepR PF18557.1 ETO20659.1 - 0.12 12.0 0.1 0.21 11.2 0.1 1.3 1 0 0 1 1 1 0 Anti-sigma factor NepR Ank_2 PF12796.7 ETO20660.1 - 1.2e-07 32.2 0.1 0.0033 18.0 0.1 2.6 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO20660.1 - 0.0024 18.3 0.1 2.2 8.9 0.0 4.2 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO20660.1 - 0.0052 17.3 0.2 2 9.1 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO20660.1 - 0.019 15.3 0.3 0.96 9.8 0.0 3.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) FAM176 PF14851.6 ETO20660.1 - 1.7 8.3 8.2 2 8.1 6.5 1.9 2 0 0 2 2 2 0 FAM176 family RGS12_us1 PF16613.5 ETO20660.1 - 7.2 7.0 9.6 6.3 7.1 7.2 2.0 1 1 1 2 2 2 0 Unstructured region of RGS12 SNase PF00565.17 ETO20662.1 - 1.2e-09 38.6 6.3 7.2e-08 32.9 0.2 2.7 3 0 0 3 3 3 2 Staphylococcal nuclease homologue DUF2076 PF09849.9 ETO20662.1 - 0.3 11.1 16.5 0.14 12.2 10.4 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) Herpes_LMP1 PF05297.11 ETO20662.1 - 5.8 6.0 10.7 8.5 5.5 10.7 1.3 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF4661 PF15576.6 ETO20662.1 - 7 6.5 7.8 0.32 10.9 1.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4661) LAP1C PF05609.12 ETO20663.1 - 9.6 5.2 27.2 15 4.5 27.2 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PP2C PF00481.21 ETO20664.1 - 1.7e-34 119.6 4.6 7e-34 117.6 4.6 2.0 1 1 0 1 1 1 1 Protein phosphatase 2C SpoIIE PF07228.12 ETO20664.1 - 0.008 16.1 0.0 0.018 14.9 0.0 1.6 1 1 0 1 1 1 1 Stage II sporulation protein E (SpoIIE) Macoilin PF09726.9 ETO20664.1 - 0.45 9.0 10.2 0.55 8.7 10.2 1.1 1 0 0 1 1 1 0 Macoilin family ETRAMP PF09716.10 ETO20665.1 - 0.013 15.6 0.9 1.7 8.8 0.0 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) GET2 PF08690.10 ETO20665.1 - 8.3 6.0 15.1 0.16 11.6 5.6 2.1 2 0 0 2 2 2 0 GET complex subunit GET2 DUF4050 PF13259.6 ETO20666.1 - 0.068 13.5 0.0 0.083 13.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) MRP-L51 PF10244.9 ETO20667.1 - 0.094 12.9 0.6 1.1 9.5 0.0 2.3 2 1 0 2 2 2 0 Mitochondrial ribosomal subunit CAP_GLY PF01302.25 ETO20668.1 - 3.4e-15 55.8 0.1 5.9e-15 55.0 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain SID-1_RNA_chan PF13965.6 ETO20668.1 - 0.018 13.5 0.5 0.026 13.0 0.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Orf78 PF06024.12 ETO20668.1 - 1.7 9.0 9.0 35 4.8 0.0 2.7 2 0 0 2 2 2 0 Orf78 (ac78) SpoIIIAH PF12685.7 ETO20668.1 - 1.9 8.3 15.8 0.012 15.4 5.5 2.1 2 0 0 2 2 2 0 SpoIIIAH-like protein Presenilin PF01080.17 ETO20668.1 - 3.9 6.1 10.1 0.11 11.3 1.9 2.0 2 0 0 2 2 2 0 Presenilin DUF832 PF05734.11 ETO20669.1 - 0.7 9.3 5.5 0.63 9.5 2.1 1.9 1 1 1 2 2 2 0 Herpesvirus protein of unknown function (DUF832) Sec7_N PF12783.7 ETO20671.1 - 2.9e-08 33.8 0.6 5e-08 33.0 0.3 1.5 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Herpes_pp85 PF04637.12 ETO20671.1 - 0.021 13.3 0.0 0.027 12.9 0.0 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) SAM_1 PF00536.30 ETO20673.1 - 6.8e-12 45.7 0.7 1.2e-11 44.9 0.7 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO20673.1 - 5.6e-10 39.2 0.5 1e-09 38.3 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_KSR1 PF13543.6 ETO20673.1 - 0.29 11.3 4.1 0.11 12.6 1.1 1.8 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 DUF2457 PF10446.9 ETO20674.1 - 3.6 6.6 22.7 7.4 5.6 22.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PUD1_2 PF18457.1 ETO20676.1 - 3e-11 43.6 1.4 2.1e-09 37.6 2.1 2.0 1 1 1 2 2 2 2 Up-Regulated in long-lived daf-2 RabGAP-TBC PF00566.18 ETO20678.1 - 1.8e-22 80.1 3.8 3.1e-19 69.5 0.7 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain G-alpha PF00503.20 ETO20679.1 - 7.5e-18 64.8 0.2 1e-17 64.3 0.2 1.3 1 0 0 1 1 1 1 G-protein alpha subunit AAA_16 PF13191.6 ETO20679.1 - 0.00072 20.0 0.0 0.00087 19.7 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain DUF815 PF05673.13 ETO20679.1 - 0.0016 17.7 0.1 0.0019 17.4 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) Roc PF08477.13 ETO20679.1 - 0.0022 18.2 0.1 0.005 17.0 0.1 1.8 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETO20679.1 - 0.0061 17.1 1.1 0.0096 16.4 0.3 1.7 1 1 0 1 1 1 1 ABC transporter NB-ARC PF00931.22 ETO20679.1 - 0.0083 15.3 0.0 0.01 15.0 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain MMR_HSR1 PF01926.23 ETO20679.1 - 0.0098 16.0 0.4 0.017 15.2 0.1 1.7 2 1 0 2 2 2 1 50S ribosome-binding GTPase Ploopntkinase3 PF18751.1 ETO20679.1 - 0.011 15.7 0.0 0.017 15.1 0.0 1.2 1 0 0 1 1 1 0 P-loop Nucleotide Kinase3 AAA_18 PF13238.6 ETO20679.1 - 0.018 15.6 0.2 0.035 14.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain Lipoprotein_Ltp PF07553.11 ETO20679.1 - 0.028 14.7 0.1 0.08 13.2 0.1 1.8 1 0 0 1 1 1 0 Host cell surface-exposed lipoprotein AAA_28 PF13521.6 ETO20679.1 - 0.029 14.6 0.2 0.043 14.1 0.0 1.5 2 0 0 2 2 1 0 AAA domain AAA_29 PF13555.6 ETO20679.1 - 0.03 14.0 0.0 0.06 13.1 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ETO20679.1 - 0.032 13.6 0.0 0.056 12.8 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family NACHT PF05729.12 ETO20679.1 - 0.04 13.9 0.0 0.055 13.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Sigma54_activat PF00158.26 ETO20679.1 - 0.046 13.4 0.0 0.068 12.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 ETO20679.1 - 0.067 12.9 0.3 0.12 12.1 0.3 1.6 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO20679.1 - 0.068 13.2 0.2 0.19 11.7 0.2 1.7 1 1 1 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 ETO20679.1 - 0.088 12.8 0.2 0.13 12.2 0.2 1.5 1 1 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Pox_A32 PF04665.12 ETO20679.1 - 0.12 11.9 2.0 0.15 11.5 0.6 2.0 1 1 1 2 2 2 0 Poxvirus A32 protein AAA_33 PF13671.6 ETO20679.1 - 0.15 12.2 0.3 0.24 11.5 0.3 1.6 1 1 0 1 1 1 0 AAA domain Xpo1 PF08389.12 ETO20680.1 - 1.4e-08 34.9 0.4 4.6e-08 33.2 0.4 1.7 2 0 0 2 2 2 1 Exportin 1-like protein zf-4CXXC_R1 PF10497.9 ETO20681.1 - 0.069 13.4 0.8 0.17 12.1 0.6 1.7 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DUF4390 PF14334.6 ETO20681.1 - 0.12 11.8 0.3 1.2 8.5 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4390) PRP1_N PF06424.12 ETO20681.1 - 0.16 12.3 0.3 0.37 11.2 0.3 1.5 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal EcsC PF12787.7 ETO20681.1 - 0.32 10.6 2.7 4.4 6.9 0.2 2.3 2 0 0 2 2 2 0 EcsC protein family Ras PF00071.22 ETO20682.1 - 2.4e-38 131.3 0.0 8e-37 126.3 0.0 2.4 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO20682.1 - 1.6e-15 57.4 0.0 4.8e-15 55.8 0.0 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO20682.1 - 0.00047 19.7 0.4 0.0015 18.0 0.0 2.0 2 1 0 2 2 2 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO20682.1 - 0.016 15.3 0.0 0.044 13.9 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO20682.1 - 0.041 13.4 0.2 3.8 7.0 0.0 3.1 2 2 1 3 3 3 0 Elongation factor Tu GTP binding domain PH PF00169.29 ETO20684.1 - 0.36 11.3 4.4 1.2 9.6 0.1 2.9 2 1 1 3 3 3 0 PH domain SPOB_a PF14689.6 ETO20685.1 - 0.12 12.1 1.8 0.42 10.4 1.1 2.3 2 0 0 2 2 2 0 Sensor_kinase_SpoOB-type, alpha-helical domain Myb_DNA-bind_5 PF13873.6 ETO20685.1 - 0.35 11.0 5.3 13 5.9 0.8 3.4 3 0 0 3 3 3 0 Myb/SANT-like DNA-binding domain Borrelia_REV PF03978.13 ETO20685.1 - 7.9 6.4 11.2 3 7.8 1.9 2.9 3 0 0 3 3 3 0 Borrelia burgdorferi REV protein Ku PF02735.16 ETO20687.1 - 6.5e-42 143.5 0.4 9.7e-42 143.0 0.0 1.5 2 0 0 2 2 2 1 Ku70/Ku80 beta-barrel domain Ku_C PF03730.14 ETO20687.1 - 7.3e-11 42.6 0.4 2.1e-10 41.2 0.3 1.9 1 1 0 1 1 1 1 Ku70/Ku80 C-terminal arm Peptidase_M91 PF14891.6 ETO20687.1 - 0.045 14.1 1.2 0.058 13.7 0.1 1.7 2 0 0 2 2 2 0 Effector protein Ku_PK_bind PF08785.11 ETO20688.1 - 8.3e-19 67.9 0.5 1.1e-18 67.5 0.5 1.1 1 0 0 1 1 1 1 Ku C terminal domain like Menin PF05053.13 ETO20691.1 - 1.3 7.3 6.0 1.3 7.3 6.0 1.0 1 0 0 1 1 1 0 Menin Clat_adaptor_s PF01217.20 ETO20693.1 - 2.1e-46 157.4 11.1 1.1e-33 116.1 5.3 2.1 1 1 1 2 2 2 2 Clathrin adaptor complex small chain DUF3611 PF12263.8 ETO20693.1 - 0.0032 17.4 0.0 0.0052 16.7 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3611) EPL1 PF10513.9 ETO20694.1 - 0.016 15.6 10.3 0.016 15.6 10.3 2.3 2 1 0 2 2 2 0 Enhancer of polycomb-like Helo_like_N PF17111.5 ETO20696.1 - 0.013 14.9 0.5 0.013 14.9 0.5 1.9 2 0 0 2 2 2 0 Fungal N-terminal domain of STAND proteins PspB PF06667.12 ETO20696.1 - 0.018 15.1 1.4 0.018 15.1 1.4 2.3 2 0 0 2 2 2 0 Phage shock protein B GAS PF13851.6 ETO20696.1 - 0.3 10.4 13.3 0.016 14.5 7.3 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding SKA1 PF07160.12 ETO20696.1 - 1.9 8.2 13.2 0.14 12.0 1.6 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 DUF4407 PF14362.6 ETO20696.1 - 2.9 7.2 8.8 6.3 6.1 8.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FAP206 PF12018.8 ETO20696.1 - 3.2 7.2 9.7 0.7 9.4 5.1 1.9 2 0 0 2 2 2 0 Domain of unknown function DUF4298 PF14131.6 ETO20696.1 - 4.6 7.3 9.6 11 6.1 0.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) BLOC1_2 PF10046.9 ETO20696.1 - 7.6 6.9 11.4 1.8 8.9 4.4 2.7 3 0 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF745 PF05335.13 ETO20696.1 - 7.8 6.2 9.1 1.7 8.3 2.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF745) SAM_2 PF07647.17 ETO20697.1 - 4.5e-12 45.9 3.6 1.3e-05 25.2 0.1 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO20697.1 - 2.4e-08 34.3 4.1 0.0041 17.5 0.1 3.3 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) DUF2683 PF10884.8 ETO20697.1 - 0.13 12.5 4.7 0.89 9.9 0.0 3.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2683) SRP14 PF02290.15 ETO20697.1 - 2.5 8.5 8.5 0.75 10.2 3.5 2.4 2 1 0 2 2 2 0 Signal recognition particle 14kD protein BLOC1_2 PF10046.9 ETO20698.1 - 0.0062 16.8 5.1 0.91 9.9 0.3 2.8 2 1 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_GP20 PF06810.11 ETO20698.1 - 0.018 14.9 4.7 0.15 11.8 0.2 2.4 2 1 0 2 2 2 0 Phage minor structural protein GP20 Prefoldin_2 PF01920.20 ETO20698.1 - 0.019 14.9 13.5 0.19 11.7 3.5 2.9 2 1 0 2 2 2 0 Prefoldin subunit Tht1 PF04163.12 ETO20698.1 - 0.02 13.7 2.1 0.036 12.8 2.1 1.4 1 1 0 1 1 1 0 Tht1-like nuclear fusion protein Phage_Gp17 PF17549.2 ETO20698.1 - 0.046 13.7 0.3 2 8.4 0.2 2.3 2 0 0 2 2 2 0 Gene Product 17 Baculo_PEP_C PF04513.12 ETO20698.1 - 0.065 13.3 2.9 3.7 7.6 0.3 2.8 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus NPV_P10 PF05531.12 ETO20698.1 - 0.11 13.0 4.9 0.79 10.2 0.2 3.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein ABC_tran_CTD PF16326.5 ETO20698.1 - 0.13 12.5 10.2 0.72 10.1 2.6 3.4 3 0 0 3 3 3 0 ABC transporter C-terminal domain Csm2_III-A PF03750.13 ETO20698.1 - 0.24 12.2 5.9 0.17 12.7 0.8 2.9 2 1 1 3 3 3 0 Csm2 Type III-A CREPT PF16566.5 ETO20698.1 - 0.54 10.4 9.0 0.35 11.1 0.9 2.5 2 1 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour CLZ PF16526.5 ETO20698.1 - 0.82 10.1 6.0 16 6.0 0.1 3.3 2 1 1 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Phe_tRNA-synt_N PF02912.18 ETO20698.1 - 1.2 9.1 5.0 3.3 7.7 2.9 2.8 2 1 0 2 2 2 0 Aminoacyl tRNA synthetase class II, N-terminal domain YabA PF06156.13 ETO20698.1 - 1.3 9.7 7.4 11 6.7 0.9 3.2 2 1 1 3 3 3 0 Initiation control protein YabA SOGA PF11365.8 ETO20698.1 - 1.4 10.1 11.1 1.9 9.7 0.9 3.2 2 1 1 3 3 3 0 Protein SOGA DUF3450 PF11932.8 ETO20698.1 - 1.5 8.1 14.8 0.92 8.8 4.7 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF1664 PF07889.12 ETO20698.1 - 1.5 8.9 9.8 2.3 8.3 0.9 3.3 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Prominin PF05478.11 ETO20698.1 - 1.8 6.4 12.5 0.15 10.0 3.7 2.0 1 1 1 2 2 2 0 Prominin COG2 PF06148.11 ETO20698.1 - 2.3 8.3 7.6 4.1 7.5 0.7 2.9 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF848 PF05852.11 ETO20698.1 - 2.6 8.2 11.1 0.33 11.1 2.9 2.5 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) ACCA PF03255.14 ETO20698.1 - 5.3 6.9 8.5 5.2 6.9 0.2 3.1 2 1 1 3 3 3 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Lectin_N PF03954.14 ETO20698.1 - 6.1 6.6 8.6 4.2 7.1 1.4 2.8 1 1 1 3 3 3 0 Hepatic lectin, N-terminal domain PBP1_TM PF14812.6 ETO20699.1 - 5 7.6 12.2 0.72 10.3 4.5 2.5 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal VHL PF01847.16 ETO20700.1 - 0.002 18.0 0.1 0.006 16.5 0.0 1.8 2 0 0 2 2 2 1 VHL beta domain zf-TRAF PF02176.18 ETO20701.1 - 1.6e-07 31.9 2.3 1.6e-07 31.9 2.3 3.5 3 1 0 3 3 3 1 TRAF-type zinc finger DivIC PF04977.15 ETO20701.1 - 1.1 9.0 7.4 1.4 8.8 1.0 2.4 2 0 0 2 2 2 0 Septum formation initiator Kelch_5 PF13854.6 ETO20702.1 - 6e-35 118.7 1.5 3.8e-08 33.1 0.0 5.8 5 1 0 5 5 5 5 Kelch motif Kelch_4 PF13418.6 ETO20702.1 - 1.5e-32 111.3 9.8 8.3e-07 28.9 0.0 6.5 7 0 0 7 7 7 5 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO20702.1 - 5.9e-29 98.9 6.1 1.3e-09 37.6 0.1 5.9 5 0 0 5 5 5 5 Kelch motif Kelch_1 PF01344.25 ETO20702.1 - 1.5e-26 91.7 8.0 1.1e-07 31.4 0.0 6.2 5 1 1 6 6 6 5 Kelch motif Kelch_6 PF13964.6 ETO20702.1 - 3.5e-25 87.4 6.0 4.5e-07 29.9 0.0 6.0 5 2 1 6 6 6 5 Kelch motif Kelch_3 PF13415.6 ETO20702.1 - 5.4e-24 84.0 20.7 1.6e-09 37.8 0.0 7.8 8 1 0 8 8 8 4 Galactose oxidase, central domain DUF2533 PF10752.9 ETO20702.1 - 0.041 14.3 0.5 0.087 13.3 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2533) SWI-SNF_Ssr4 PF08549.10 ETO20702.1 - 0.1 11.3 8.9 0.15 10.7 8.9 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Connexin PF00029.19 ETO20703.1 - 0.11 12.2 1.9 0.13 12.0 1.9 1.1 1 0 0 1 1 1 0 Connexin Peptidase_S49_N PF08496.10 ETO20703.1 - 0.13 12.3 7.5 0.15 12.1 7.5 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Ctr PF04145.15 ETO20703.1 - 0.2 12.3 0.4 0.21 12.2 0.4 1.0 1 0 0 1 1 1 0 Ctr copper transporter family AP3D1 PF06375.11 ETO20703.1 - 0.42 10.8 13.0 0.52 10.5 13.0 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF3464 PF11947.8 ETO20703.1 - 3.1 7.5 6.0 3.7 7.3 6.0 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 SR-25 PF10500.9 ETO20703.1 - 8.1 6.0 19.2 9.5 5.8 19.2 1.0 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein U3snoRNP10 PF12397.8 ETO20704.1 - 0.0025 18.2 0.6 0.013 15.8 0.1 2.3 2 0 0 2 2 2 1 U3 small nucleolar RNA-associated protein 10 BP28CT PF08146.12 ETO20705.1 - 3.9e-07 30.0 4.4 3.2e-06 27.1 2.0 3.7 2 0 0 2 2 2 1 BP28CT (NUC211) domain Vac14_Fab1_bd PF12755.7 ETO20705.1 - 0.018 15.6 0.1 1.2 9.8 0.0 3.8 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region RPN2_C PF18004.1 ETO20705.1 - 8.5 6.3 11.0 11 6.0 1.1 2.6 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4942 PF13708.6 ETO20706.1 - 0.0046 17.0 0.5 0.01 15.8 0.5 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4942) Clathrin PF00637.20 ETO20706.1 - 0.014 15.2 1.5 0.24 11.3 0.8 2.4 2 0 0 2 2 2 0 Region in Clathrin and VPS PPR_2 PF13041.6 ETO20706.1 - 0.022 14.9 0.1 0.86 9.9 0.0 3.0 4 0 0 4 4 4 0 PPR repeat family DUF4786 PF16027.5 ETO20706.1 - 0.048 14.2 0.0 0.092 13.3 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4786) INTS5_N PF14837.6 ETO20706.1 - 0.19 11.3 6.3 0.16 11.6 3.0 2.4 2 1 0 2 2 2 0 Integrator complex subunit 5 N-terminus GIT1_C PF12205.8 ETO20706.1 - 0.35 11.0 4.0 39 4.4 0.1 3.2 3 0 0 3 3 3 0 G protein-coupled receptor kinase-interacting protein 1 C term RNA_polI_A14 PF08203.11 ETO20706.1 - 0.81 10.5 3.1 3 8.6 0.1 2.7 1 1 2 3 3 3 0 Yeast RNA polymerase I subunit RPA14 WD40 PF00400.32 ETO20708.1 - 3.2e-47 157.5 10.7 1.1e-08 35.5 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20708.1 - 1.1e-22 80.1 0.9 0.00029 21.1 0.1 7.4 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20708.1 - 6.9e-15 54.8 0.5 0.064 12.2 0.0 5.8 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO20708.1 - 9e-09 35.0 4.4 6 6.9 0.1 6.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Kelch_1 PF01344.25 ETO20708.1 - 3.5e-05 23.3 0.8 0.027 14.1 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Nup160 PF11715.8 ETO20708.1 - 5.4e-05 22.0 0.7 4.7 5.7 0.0 4.2 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO20708.1 - 0.0018 16.9 0.1 0.0063 15.1 0.1 1.9 1 1 0 1 1 1 1 Cytochrome D1 heme domain Kelch_4 PF13418.6 ETO20708.1 - 0.0028 17.6 0.3 0.022 14.7 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO20708.1 - 0.005 17.1 6.6 1.1 9.6 0.1 5.2 6 0 0 6 6 6 1 Kelch motif Proteasome_A_N PF10584.9 ETO20708.1 - 0.0051 16.5 7.1 12 5.7 0.0 5.4 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Kelch_5 PF13854.6 ETO20708.1 - 0.015 15.3 0.5 9.5 6.3 0.4 3.4 3 0 0 3 3 3 0 Kelch motif DUF5570 PF17731.1 ETO20708.1 - 0.039 14.0 0.1 37 4.4 0.0 4.2 3 2 2 5 5 5 0 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO20708.1 - 0.054 12.8 0.2 13 5.0 0.0 3.3 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Kelch_2 PF07646.15 ETO20708.1 - 0.065 13.2 2.7 12 6.1 0.0 4.4 5 0 0 5 5 4 0 Kelch motif PQQ_2 PF13360.6 ETO20708.1 - 0.086 12.4 0.0 0.21 11.2 0.0 1.7 1 1 0 1 1 1 0 PQQ-like domain Peptidase_C33 PF05412.12 ETO20708.1 - 0.14 12.2 0.1 0.53 10.3 0.0 2.0 2 0 0 2 2 2 0 Equine arterivirus Nsp2-type cysteine proteinase WD40 PF00400.32 ETO20709.1 - 1.4e-24 85.9 20.9 2.9e-05 24.7 0.0 6.6 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20709.1 - 2.5e-05 24.5 0.4 1.6 9.1 0.0 4.3 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20709.1 - 0.00013 20.8 4.6 0.083 11.5 0.7 4.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO20709.1 - 0.0022 16.8 2.2 1 8.1 0.1 3.2 1 1 1 3 3 3 2 Nup133 N terminal like Sporozoite_P67 PF05642.11 ETO20710.1 - 0.02 13.0 5.8 0.029 12.5 5.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2757 PF10955.8 ETO20710.1 - 0.086 13.1 0.4 0.086 13.1 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) PDDEXK_6 PF04720.12 ETO20710.1 - 6.7 6.6 8.2 14 5.6 8.2 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function LZ_Tnp_IS66 PF13007.7 ETO20711.1 - 0.0024 18.6 2.6 0.0024 18.6 2.6 2.9 3 1 0 3 3 3 1 Transposase C of IS166 homeodomain WD40 PF00400.32 ETO20712.1 - 6e-11 42.7 10.2 3.9e-07 30.7 0.4 4.4 4 0 0 4 4 4 2 WD domain, G-beta repeat Velvet PF11754.8 ETO20712.1 - 0.78 9.6 9.4 4.6 7.1 6.7 2.3 2 0 0 2 2 2 0 Velvet factor Lipase_GDSL PF00657.22 ETO20713.1 - 0.0093 16.0 0.3 0.03 14.3 0.0 1.8 2 1 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase RRM_1 PF00076.22 ETO20714.1 - 0.026 14.4 0.0 0.054 13.3 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SelP_N PF04592.14 ETO20714.1 - 2.2 7.6 5.4 3.6 6.9 5.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ubiquitin PF00240.23 ETO20715.1 - 0.001 18.7 0.0 0.0025 17.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Rootletin PF15035.6 ETO20716.1 - 0.015 15.3 8.7 0.021 14.8 8.7 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion betaPIX_CC PF16523.5 ETO20716.1 - 0.12 12.2 3.9 0.19 11.6 0.6 2.1 2 0 0 2 2 2 0 betaPIX coiled coil AAA_22 PF13401.6 ETO20718.1 - 0.00032 21.0 0.1 0.0014 18.9 0.2 2.1 2 1 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETO20718.1 - 0.0062 16.3 0.6 0.03 14.0 0.3 2.1 1 1 0 1 1 1 1 AAA domain NTPase_1 PF03266.15 ETO20718.1 - 0.31 10.9 2.6 0.5 10.3 0.7 2.1 2 0 0 2 2 2 0 NTPase FAD_binding_3 PF01494.19 ETO20719.1 - 0.00083 18.7 0.0 0.0014 18.0 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Ribosomal_L7Ae PF01248.26 ETO20719.1 - 0.034 13.9 0.5 0.068 12.9 0.5 1.5 1 0 0 1 1 1 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family FAD_binding_3 PF01494.19 ETO20720.1 - 1.1e-06 28.2 0.0 1.2e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain SE PF08491.10 ETO20720.1 - 0.00036 19.7 0.0 0.00047 19.3 0.0 1.2 1 0 0 1 1 1 1 Squalene epoxidase UPRTase PF14681.6 ETO20721.1 - 8.8e-39 133.1 0.0 1.4e-38 132.5 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase Pribosyltran PF00156.27 ETO20721.1 - 0.00043 19.8 0.0 0.00074 19.1 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Thoc2 PF11732.8 ETO20723.1 - 0.16 12.0 1.4 0.25 11.4 0.2 1.9 2 0 0 2 2 2 0 Transcription- and export-related complex subunit AgrB PF04647.15 ETO20723.1 - 2.1 7.6 7.9 0.059 12.7 0.8 2.1 2 1 0 2 2 2 0 Accessory gene regulator B Menin PF05053.13 ETO20724.1 - 1.1 7.5 9.3 1.3 7.3 9.3 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO20724.1 - 4.5 6.4 5.8 5.7 6.1 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PepSY_TM_like_2 PF16357.5 ETO20725.1 - 0.00011 22.2 0.1 0.00026 21.0 0.0 1.5 2 0 0 2 2 2 1 Putative PepSY_TM-like PIP5K PF01504.18 ETO20726.1 - 7.9e-10 38.4 0.0 1.1e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF2207 PF09972.9 ETO20726.1 - 0.13 11.0 2.2 0.15 10.8 2.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) AA_permease_2 PF13520.6 ETO20726.1 - 0.23 10.2 9.3 0.3 9.9 9.3 1.1 1 0 0 1 1 1 0 Amino acid permease EVC2_like PF12297.8 ETO20726.1 - 3 6.4 9.0 4.1 6.0 9.0 1.2 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein cNMP_binding PF00027.29 ETO20727.1 - 2.7e-34 117.1 0.1 3.8e-15 55.7 0.0 3.3 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Pkinase PF00069.25 ETO20727.1 - 5.9e-15 55.4 0.0 1e-14 54.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20727.1 - 2.5e-05 23.7 0.1 4e-05 23.0 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO20728.1 - 2.3e-40 138.7 0.0 3.4e-40 138.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20728.1 - 3.2e-15 56.1 0.0 5.1e-15 55.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO20728.1 - 1.1e-05 24.9 0.0 1.8e-05 24.2 0.0 1.3 1 1 0 1 1 1 1 Kinase-like PEPcase PF00311.17 ETO20728.1 - 0.062 11.4 0.3 0.084 10.9 0.3 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Seadorna_VP7 PF07387.11 ETO20728.1 - 0.088 11.8 0.0 0.12 11.4 0.0 1.1 1 0 0 1 1 1 0 Seadornavirus VP7 ATP-gua_Ptrans PF00217.19 ETO20730.1 - 2.3e-18 66.4 0.0 7e-18 64.9 0.0 1.6 1 1 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain DUF5026 PF16429.5 ETO20730.1 - 0.11 12.6 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5026) TMEM100 PF16311.5 ETO20731.1 - 7.2 6.2 7.4 12 5.5 7.4 1.8 1 1 0 1 1 1 0 Transmembrane protein 100 uDENN PF03456.18 ETO20733.1 - 8.5e-14 52.1 0.8 3.1e-13 50.3 0.8 2.1 1 0 0 1 1 1 1 uDENN domain Peptidase_C37 PF05416.12 ETO20734.1 - 0.0027 16.3 2.6 0.0035 16.0 2.6 1.1 1 0 0 1 1 1 1 Southampton virus-type processing peptidase CENP-N PF05238.13 ETO20734.1 - 0.44 9.8 12.9 0.61 9.3 12.9 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like DUF4611 PF15387.6 ETO20734.1 - 0.51 10.6 17.3 0.54 10.5 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) CPP1-like PF11833.8 ETO20734.1 - 0.96 9.1 2.9 1.7 8.2 2.9 1.4 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like tRNA-synt_1c PF00749.21 ETO20735.1 - 3.6e-62 210.1 0.0 4.7e-62 209.7 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ETO20735.1 - 2.5e-30 105.6 0.0 4.5e-30 104.8 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain HTH_30 PF13556.6 ETO20736.1 - 0.016 15.0 0.1 0.027 14.3 0.1 1.3 1 0 0 1 1 1 0 PucR C-terminal helix-turn-helix domain DUF2730 PF10805.8 ETO20736.1 - 0.021 14.9 0.2 0.068 13.3 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) DUF2884 PF11101.8 ETO20736.1 - 0.03 13.8 1.0 0.044 13.3 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) DUF1664 PF07889.12 ETO20736.1 - 0.035 14.2 1.3 0.055 13.5 1.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Noelin-1 PF12308.8 ETO20736.1 - 0.036 14.0 2.2 0.058 13.4 2.2 1.3 1 0 0 1 1 1 0 Neurogenesis glycoprotein WASH_WAHD PF11945.8 ETO20736.1 - 0.058 12.9 2.3 0.11 12.0 1.2 1.7 2 0 0 2 2 2 0 WAHD domain of WASH complex Fzo_mitofusin PF04799.13 ETO20736.1 - 0.063 12.8 2.5 0.1 12.1 2.5 1.3 1 0 0 1 1 1 0 fzo-like conserved region KxDL PF10241.9 ETO20736.1 - 0.069 13.4 2.4 0.18 12.1 2.4 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein Occludin_ELL PF07303.13 ETO20736.1 - 0.077 13.7 1.2 0.077 13.7 1.2 1.6 2 0 0 2 2 1 0 Occludin homology domain bZIP_2 PF07716.15 ETO20736.1 - 0.077 13.1 1.1 1.6 8.8 0.2 2.4 1 1 1 2 2 2 0 Basic region leucine zipper TMPIT PF07851.13 ETO20736.1 - 0.13 11.5 2.6 0.13 11.5 1.3 1.6 2 0 0 2 2 2 0 TMPIT-like protein ECM11 PF15463.6 ETO20736.1 - 0.15 12.6 3.1 0.25 11.9 3.1 1.3 1 0 0 1 1 1 0 Extracellular mutant protein 11 Adaptin_N PF01602.20 ETO20737.1 - 1.1e-38 133.1 0.1 1.4e-38 132.8 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO20737.1 - 3.6e-14 53.1 0.0 4.5e-14 52.8 0.0 1.1 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO20737.1 - 6.6e-05 23.2 0.0 0.041 14.3 0.0 2.3 1 1 0 2 2 2 2 HEAT repeats HEAT PF02985.22 ETO20737.1 - 0.00031 20.7 1.8 4.2 7.9 0.0 3.8 4 0 0 4 4 4 2 HEAT repeat RTP1_C1 PF10363.9 ETO20737.1 - 0.003 17.7 0.0 0.0046 17.1 0.0 1.4 1 0 0 1 1 1 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_UF PF18817.1 ETO20737.1 - 0.096 13.0 0.0 0.51 10.6 0.0 2.2 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 API5 PF05918.11 ETO20737.1 - 0.1 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Apoptosis inhibitory protein 5 (API5) Myosin_TH1 PF06017.13 ETO20739.1 - 3e-16 59.7 0.4 3e-16 59.7 0.4 1.4 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 ETO20739.1 - 0.0055 16.4 0.0 0.011 15.5 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase EbsA PF17255.2 ETO20739.1 - 0.024 15.0 1.6 0.096 13.0 0.1 2.2 2 0 0 2 2 2 0 EbsA-like protein CTP_transf_like PF01467.26 ETO20740.1 - 1.5e-07 31.7 0.0 4.1e-07 30.3 0.0 1.8 1 1 0 1 1 1 1 Cytidylyltransferase-like DEK_C PF08766.11 ETO20740.1 - 0.063 13.2 0.3 0.33 10.9 0.0 2.1 1 1 1 2 2 2 0 DEK C terminal domain HemN_C PF06969.16 ETO20741.1 - 0.012 15.6 0.0 0.021 14.9 0.0 1.4 1 0 0 1 1 1 0 HemN C-terminal domain PI3K_C2 PF00792.24 ETO20742.1 - 0.00011 22.1 0.0 0.00016 21.6 0.0 1.5 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 CPSF100_C PF13299.6 ETO20743.1 - 0.042 14.0 2.4 0.19 11.9 1.5 2.0 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PH_4 PF15404.6 ETO20743.1 - 0.27 11.0 4.9 7.6 6.3 2.8 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain NPR3 PF03666.13 ETO20743.1 - 4.8 5.8 11.1 0.2 10.4 5.4 1.5 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 PDCD2_C PF04194.13 ETO20744.1 - 0.0016 18.5 4.5 0.061 13.4 0.0 2.1 2 0 0 2 2 2 1 Programmed cell death protein 2, C-terminal putative domain LRS4 PF10422.9 ETO20744.1 - 0.015 14.9 0.0 0.02 14.5 0.0 1.3 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 Radial_spoke PF04712.12 ETO20744.1 - 0.02 13.9 3.4 0.023 13.7 3.4 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein Dicty_REP PF05086.12 ETO20744.1 - 0.1 10.5 2.5 0.14 10.1 2.5 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Nop14 PF04147.12 ETO20744.1 - 0.12 10.6 5.1 0.13 10.4 5.1 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ETO20744.1 - 0.32 10.3 7.7 0.41 9.9 7.7 1.1 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.11 ETO20744.1 - 0.36 8.8 3.5 0.43 8.6 3.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.6 ETO20744.1 - 0.41 10.3 4.6 0.62 9.7 4.6 1.2 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ETO20744.1 - 0.5 10.8 10.3 0.81 10.1 10.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC45 PF02724.14 ETO20744.1 - 1.1 7.4 7.3 0.93 7.7 5.8 1.5 2 0 0 2 2 2 0 CDC45-like protein DUF4637 PF15470.6 ETO20744.1 - 1.6 8.4 6.8 2.5 7.8 6.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3108 PF11306.8 ETO20745.1 - 0.002 18.1 2.5 0.019 15.0 2.5 2.3 1 1 0 1 1 1 1 Protein of unknown function (DUF3108) DUF1387 PF07139.11 ETO20745.1 - 0.04 13.7 31.6 0.015 15.0 23.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) CDC45 PF02724.14 ETO20745.1 - 0.18 10.0 24.0 0.35 9.1 24.0 1.4 1 0 0 1 1 1 0 CDC45-like protein YfdX PF10938.8 ETO20746.1 - 0.019 14.9 0.2 8.3 6.3 0.2 2.4 2 1 0 2 2 2 0 YfdX protein Glyco_transf_49 PF13896.6 ETO20747.1 - 1e-30 107.3 0.6 5e-30 105.0 0.6 1.8 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Glycos_transf_2 PF00535.26 ETO20747.1 - 0.00073 19.4 0.0 0.0013 18.6 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_2 PF10111.9 ETO20747.1 - 0.00099 18.7 0.0 0.0022 17.5 0.0 1.5 2 0 0 2 2 2 1 Glycosyltransferase like family 2 Glyco_tranf_2_4 PF13704.6 ETO20747.1 - 0.073 13.6 0.1 0.14 12.7 0.1 1.5 1 0 0 1 1 1 0 Glycosyl transferase family 2 CLPTM1 PF05602.12 ETO20748.1 - 4.3e-117 391.8 4.8 5.2e-117 391.5 4.8 1.1 1 0 0 1 1 1 1 Cleft lip and palate transmembrane protein 1 (CLPTM1) MtN3_slv PF03083.16 ETO20748.1 - 0.0018 18.2 2.5 0.0018 18.2 2.5 2.0 2 0 0 2 2 2 1 Sugar efflux transporter for intercellular exchange G-alpha PF00503.20 ETO20749.1 - 1.6e-24 86.7 0.4 2e-24 86.5 0.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit G-alpha PF00503.20 ETO20750.1 - 1.3e-49 169.2 0.6 1.6e-49 168.9 0.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO20750.1 - 0.00048 19.6 0.0 0.00078 18.9 0.0 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family zf-HC5HC2H_2 PF13832.6 ETO20750.1 - 0.14 12.3 3.1 1.6 8.9 1.5 2.2 2 0 0 2 2 2 0 PHD-zinc-finger like domain WD40 PF00400.32 ETO20751.1 - 5.1e-34 115.7 29.9 4.3e-07 30.5 0.7 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20751.1 - 2.3e-07 31.0 4.4 0.3 11.4 0.0 5.4 4 2 3 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20751.1 - 4.1e-05 22.4 11.7 0.12 11.0 0.7 5.1 2 2 3 5 5 5 4 Nucleoporin Nup120/160 GHMP_kinases_C PF08544.13 ETO20753.1 - 4.8e-10 39.7 0.0 6.1e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 GHMP kinases C terminal Phage_gp49_66 PF13876.6 ETO20753.1 - 0.0088 16.3 0.0 0.016 15.5 0.0 1.4 1 0 0 1 1 1 1 Phage protein (N4 Gp49/phage Sf6 gene 66) family Pkinase_C PF00433.24 ETO20754.1 - 0.001 19.7 3.2 0.013 16.2 3.2 2.6 1 1 0 1 1 1 1 Protein kinase C terminal domain XK-related PF09815.9 ETO20755.1 - 3.6e-13 49.3 20.5 1.2e-12 47.6 20.5 1.9 1 1 0 1 1 1 1 XK-related protein Kelch_6 PF13964.6 ETO20756.1 - 0.033 14.5 0.1 3 8.3 0.0 3.3 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO20756.1 - 0.77 9.4 5.9 6.1 6.5 0.0 3.3 3 0 0 3 3 3 0 Kelch motif zf-RING_2 PF13639.6 ETO20757.1 - 9.3e-10 38.7 8.9 2.1e-09 37.6 8.9 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETO20757.1 - 6.6e-06 26.3 9.2 1.7e-05 25.0 9.2 1.7 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-RING_11 PF17123.5 ETO20757.1 - 0.00014 21.6 6.4 0.0004 20.1 6.4 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO20757.1 - 0.0004 20.2 10.7 0.0019 18.0 10.7 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-LITAF-like PF10601.9 ETO20757.1 - 0.00049 20.3 0.4 0.00049 20.3 0.4 2.5 3 0 0 3 3 3 1 LITAF-like zinc ribbon domain zf-ANAPC11 PF12861.7 ETO20757.1 - 0.0094 16.0 2.1 0.021 14.9 2.1 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ETO20757.1 - 0.027 14.6 8.8 0.027 14.6 8.8 1.9 2 0 0 2 2 2 0 RING-variant domain zf-RING_5 PF14634.6 ETO20757.1 - 0.12 12.4 9.1 0.33 10.9 9.1 1.8 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO20757.1 - 0.15 12.1 6.8 0.063 13.3 3.2 2.3 2 1 0 2 2 2 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO20757.1 - 0.23 11.3 13.1 0.051 13.4 9.0 2.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO20757.1 - 0.51 10.2 15.0 0.076 12.9 10.0 2.3 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DZR PF12773.7 ETO20757.1 - 0.63 10.1 5.7 0.36 10.9 0.5 2.3 1 1 1 2 2 2 0 Double zinc ribbon FANCL_C PF11793.8 ETO20757.1 - 0.81 9.9 9.1 60 3.9 9.1 2.7 1 1 0 1 1 1 0 FANCL C-terminal domain Dus PF01207.17 ETO20758.1 - 1.3e-27 96.8 0.0 1.4e-27 96.6 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Thioredoxin_16 PF18569.1 ETO20759.1 - 0.032 14.3 1.0 0.098 12.8 0.8 1.9 1 1 1 2 2 2 0 Thioredoxin-like domain Alpha-L-AF_C PF06964.12 ETO20759.1 - 0.11 12.7 0.2 0.15 12.2 0.2 1.1 1 0 0 1 1 1 0 Alpha-L-arabinofuranosidase C-terminal domain LRR_8 PF13855.6 ETO20761.1 - 3.5e-05 23.5 3.1 3.5e-05 23.5 3.1 2.9 1 1 1 2 2 2 1 Leucine rich repeat LRR_4 PF12799.7 ETO20761.1 - 8e-05 22.9 5.3 8e-05 22.9 5.3 2.8 3 1 0 3 3 3 2 Leucine Rich repeats (2 copies) Recep_L_domain PF01030.24 ETO20761.1 - 0.21 11.7 8.7 0.086 13.0 1.7 2.3 1 1 1 2 2 2 0 Receptor L domain LRR_4 PF12799.7 ETO20762.1 - 1.7e-05 25.1 14.8 6.6e-05 23.2 6.0 2.6 2 1 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO20762.1 - 1.7e-05 24.4 3.1 1.7e-05 24.4 3.1 2.7 1 1 1 2 2 2 1 Leucine rich repeat LRR_1 PF00560.33 ETO20762.1 - 3.1 8.7 13.4 8.7 7.3 0.4 3.7 3 1 0 3 3 3 0 Leucine Rich Repeat U-box PF04564.15 ETO20763.1 - 1.5e-10 41.1 0.0 5e-10 39.4 0.0 2.0 1 0 0 1 1 1 1 U-box domain Kelch_6 PF13964.6 ETO20763.1 - 1.8e-06 28.0 3.3 0.025 14.9 0.2 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO20763.1 - 5.1e-05 22.8 1.9 0.033 13.8 0.3 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO20763.1 - 0.067 13.2 0.7 2.5 8.2 0.1 3.1 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF4226 PF10774.9 ETO20763.1 - 0.1 12.9 0.0 0.28 11.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4226) Kelch_2 PF07646.15 ETO20763.1 - 0.26 11.4 3.5 27 5.0 0.8 3.4 3 0 0 3 3 3 0 Kelch motif CAP_GLY PF01302.25 ETO20764.1 - 2e-17 63.0 1.0 4.6e-17 61.8 1.0 1.7 1 0 0 1 1 1 1 CAP-Gly domain SH3_9 PF14604.6 ETO20764.1 - 0.026 14.4 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 Variant SH3 domain Pkinase PF00069.25 ETO20769.1 - 6e-68 229.1 0.0 1.2e-67 228.1 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20769.1 - 2.9e-31 108.7 0.0 5.7e-31 107.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO20769.1 - 0.0031 16.9 0.0 0.013 14.9 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Pox_ser-thr_kin PF05445.11 ETO20769.1 - 0.016 14.2 0.6 0.029 13.3 0.2 1.6 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 ETO20769.1 - 0.035 13.5 0.1 0.096 12.0 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO20769.1 - 0.2 11.6 0.0 0.37 10.7 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2205 PF10224.9 ETO20770.1 - 0.02 14.9 0.0 8.2 6.5 0.0 2.7 2 0 0 2 2 2 0 Short coiled-coil protein DUF4633 PF15464.6 ETO20770.1 - 0.18 12.0 0.3 0.34 11.1 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) T4_Gp59_N PF08993.10 ETO20770.1 - 0.18 12.2 2.4 0.29 11.6 0.3 2.5 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase ResB PF05140.14 ETO20772.1 - 0.013 14.3 3.3 0.034 12.9 0.0 2.0 2 0 0 2 2 2 0 ResB-like family Halogen_Hydrol PF10112.9 ETO20772.1 - 0.04 14.0 2.2 0.034 14.2 1.1 1.4 1 1 0 1 1 1 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein ATG16 PF08614.11 ETO20773.1 - 0.002 18.4 10.0 0.002 18.4 10.0 2.0 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF641 PF04859.12 ETO20773.1 - 0.0027 18.0 6.2 0.0027 18.0 6.2 2.3 2 1 0 2 2 2 1 Plant protein of unknown function (DUF641) MCU PF04678.13 ETO20773.1 - 0.62 10.1 10.6 0.3 11.2 4.0 2.3 2 0 0 2 2 2 0 Mitochondrial calcium uniporter Rx_N PF18052.1 ETO20773.1 - 2.3 8.6 7.8 0.23 11.8 2.4 2.2 2 1 0 2 2 2 0 Rx N-terminal domain DUF1664 PF07889.12 ETO20773.1 - 3.6 7.7 8.4 0.055 13.5 0.7 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO20773.1 - 4.7 7.7 24.5 0.65 10.5 8.1 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region Na_trans_assoc PF06512.13 ETO20774.1 - 0.0048 17.2 0.8 0.0048 17.2 0.8 2.0 2 0 0 2 2 2 1 Sodium ion transport-associated Tmemb_9 PF05434.11 ETO20774.1 - 3 7.8 4.8 2.6 7.9 0.1 2.5 2 0 0 2 2 2 0 TMEM9 PetM PF08041.11 ETO20775.1 - 2.4 7.8 4.9 4.3 7.0 4.9 1.4 1 0 0 1 1 1 0 PetM family of cytochrome b6f complex subunit 7 Coprogen_oxidas PF01218.18 ETO20776.1 - 7.7e-109 363.0 0.1 1.1e-108 362.5 0.1 1.3 1 0 0 1 1 1 1 Coproporphyrinogen III oxidase Myco_arth_vir_N PF09610.10 ETO20776.1 - 1.1 9.4 5.3 0.34 11.0 1.9 2.0 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) SNARE PF05739.19 ETO20777.1 - 1.4e-06 28.1 0.3 4.6e-06 26.5 0.3 1.9 1 0 0 1 1 1 1 SNARE domain Syntaxin_2 PF14523.6 ETO20777.1 - 1.3e-05 25.5 6.4 1.3e-05 25.5 6.4 2.3 2 1 0 2 2 2 1 Syntaxin-like protein MCU PF04678.13 ETO20777.1 - 0.0074 16.4 7.7 0.18 11.9 7.7 2.4 1 1 0 1 1 1 1 Mitochondrial calcium uniporter Raf1_N PF18578.1 ETO20777.1 - 0.061 13.8 0.8 0.061 13.8 0.8 2.0 2 0 0 2 2 2 0 Rubisco accumulation factor 1 alpha helical domain Laminin_II PF06009.12 ETO20777.1 - 0.062 13.3 9.2 0.19 11.7 1.6 2.5 2 0 0 2 2 2 0 Laminin Domain II AAA_5 PF07728.14 ETO20777.1 - 0.1 12.6 0.4 0.2 11.6 0.4 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) TRIQK PF15168.6 ETO20777.1 - 0.46 10.4 4.0 15 5.5 0.3 2.8 3 0 0 3 3 2 0 Triple QxxK/R motif-containing protein family DUF2207 PF09972.9 ETO20777.1 - 0.48 9.1 5.0 0.45 9.2 0.0 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) COMP PF11598.8 ETO20777.1 - 0.51 10.9 4.8 0.14 12.6 1.0 2.1 2 0 0 2 2 1 0 Cartilage oligomeric matrix protein BLOC1_2 PF10046.9 ETO20777.1 - 0.73 10.2 14.3 1.2 9.5 3.9 3.2 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FliD_N PF02465.18 ETO20777.1 - 1.3 9.8 8.5 3 8.6 0.6 2.7 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus ASC PF00858.24 ETO20777.1 - 1.5 7.7 4.9 0.36 9.8 0.4 1.9 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel IZUMO PF15005.6 ETO20777.1 - 1.8 9.1 7.6 2.7 8.5 2.5 2.7 1 1 2 3 3 3 0 Izumo sperm-egg fusion, Ig domain-associated Fib_alpha PF08702.10 ETO20777.1 - 1.9 8.7 19.8 2.2 8.4 6.9 2.9 1 1 0 3 3 3 0 Fibrinogen alpha/beta chain family Rx_N PF18052.1 ETO20777.1 - 4.3 7.7 14.8 5.2 7.4 4.7 2.5 1 1 1 2 2 2 0 Rx N-terminal domain DUF948 PF06103.11 ETO20777.1 - 5.2 7.4 8.3 8.4 6.7 1.5 3.1 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_12 PF13424.6 ETO20778.1 - 1.9e-80 265.2 19.2 1.8e-18 66.6 1.5 7.1 4 3 3 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO20778.1 - 3.5e-56 185.7 5.4 3.8e-08 33.0 0.1 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO20778.1 - 2.3e-48 158.7 12.3 6.7e-06 25.8 0.0 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO20778.1 - 1.2e-44 148.3 41.7 3.8e-08 32.8 0.2 9.0 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO20778.1 - 2.3e-34 114.7 40.0 1e-05 25.3 0.7 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO20778.1 - 1.7e-33 112.0 46.9 0.00043 20.3 0.7 10.1 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO20778.1 - 1.3e-12 47.1 18.3 0.086 13.3 0.1 8.1 6 1 2 8 8 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO20778.1 - 6.5e-12 45.2 0.3 1.6 9.8 0.0 7.6 7 1 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO20778.1 - 1.7e-07 31.8 1.6 21 5.8 0.0 6.0 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO20778.1 - 1.4e-06 28.0 0.1 0.0065 15.9 0.2 2.4 2 0 0 2 2 2 2 MalT-like TPR region TPR_6 PF13174.6 ETO20778.1 - 2.4e-05 24.7 22.0 0.82 10.4 0.2 8.5 9 0 0 9 9 8 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO20778.1 - 6.7e-05 22.5 41.8 0.027 14.2 0.2 10.4 6 2 4 10 10 9 3 TPR repeat TPR_19 PF14559.6 ETO20778.1 - 0.00045 20.7 3.6 2.3 8.8 0.3 5.1 4 1 1 5 5 4 1 Tetratricopeptide repeat PPR PF01535.20 ETO20778.1 - 0.004 17.3 14.4 1 9.7 0.0 6.6 8 0 0 8 8 7 2 PPR repeat Fis1_TPR_C PF14853.6 ETO20778.1 - 0.0098 16.0 19.1 1.7 8.8 1.3 6.0 5 0 0 5 5 5 1 Fis1 C-terminal tetratricopeptide repeat DUF5113 PF17140.4 ETO20778.1 - 0.011 15.5 22.9 0.27 11.0 0.8 6.8 4 2 3 7 7 7 0 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO20778.1 - 0.024 14.9 22.4 0.87 9.9 0.4 5.6 2 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO20778.1 - 0.028 14.5 24.8 2.2 8.4 0.1 7.6 9 0 0 9 9 8 0 MIT (microtubule interacting and transport) domain baeRF_family10 PF18854.1 ETO20778.1 - 0.095 13.0 1.4 2.9 8.1 0.0 2.8 3 0 0 3 3 3 0 Bacterial archaeo-eukaryotic release factor family 10 DUF3856 PF12968.7 ETO20778.1 - 0.77 9.8 8.6 20 5.3 0.2 4.7 3 2 2 5 5 5 0 Domain of Unknown Function (DUF3856) YflT PF11181.8 ETO20778.1 - 1.2 9.7 5.0 13 6.4 0.0 3.8 4 0 0 4 4 3 0 Heat induced stress protein YflT DUF627 PF04781.12 ETO20778.1 - 2.3 8.3 15.3 14 5.8 1.0 5.3 3 2 2 5 5 5 0 Protein of unknown function (DUF627) Pullulanase_Ins PF18494.1 ETO20778.1 - 3.1 8.3 7.5 1.4 9.4 0.1 3.5 4 0 0 4 4 3 0 Pullulanase Ins domain PPR_2 PF13041.6 ETO20778.1 - 7.2 6.9 9.3 28 5.0 0.0 5.1 6 0 0 6 6 4 0 PPR repeat family WD40 PF00400.32 ETO20779.1 - 2.1e-25 88.5 9.2 1.2e-05 25.9 0.7 5.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20779.1 - 1.6e-10 41.1 0.6 0.14 12.5 0.0 4.9 3 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO20779.1 - 1e-06 27.7 2.9 0.07 11.8 0.1 4.3 2 1 3 5 5 5 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO20779.1 - 1.9e-06 28.4 3.5 8.8e-06 26.3 3.5 2.3 1 0 0 1 1 1 1 TRAF-type zinc finger ThiD2 PF17792.1 ETO20779.1 - 0.036 14.5 0.2 0.083 13.4 0.2 1.6 1 0 0 1 1 1 0 ThiD2 family LIN52 PF10044.9 ETO20779.1 - 0.43 11.3 3.6 30 5.4 0.8 3.0 2 0 0 2 2 2 0 Retinal tissue protein TPR_MLP1_2 PF07926.12 ETO20779.1 - 1.2 9.2 14.4 0.36 10.9 4.9 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1691 PF07950.11 ETO20780.1 - 4.1 8.2 6.0 8.9 7.1 3.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1691) DUF5321 PF17254.2 ETO20781.1 - 0.076 12.5 2.7 0.087 12.3 2.7 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5321) Apis_Csd PF11671.8 ETO20781.1 - 3.4 7.7 15.6 4.2 7.4 15.6 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein EF-hand_7 PF13499.6 ETO20782.1 - 0.0022 18.4 0.7 0.0036 17.7 0.7 1.5 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO20782.1 - 0.0023 17.4 0.9 0.0046 16.4 0.2 1.8 2 0 0 2 2 2 1 EF hand Rtf2 PF04641.12 ETO20782.1 - 0.0029 17.0 14.5 0.0034 16.8 14.5 1.2 1 0 0 1 1 1 1 Rtf2 RING-finger EF-hand_6 PF13405.6 ETO20782.1 - 0.0047 16.8 0.8 0.013 15.4 0.5 1.8 2 0 0 2 2 2 1 EF-hand domain GAGA_bind PF06217.12 ETO20782.1 - 0.02 15.2 9.8 0.019 15.3 9.8 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DUF2052 PF09747.9 ETO20782.1 - 0.026 14.6 12.4 0.028 14.5 12.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.6 ETO20782.1 - 0.027 14.6 8.2 0.029 14.5 8.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 ETO20782.1 - 0.028 14.9 8.1 0.03 14.7 8.1 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 RRN3 PF05327.11 ETO20782.1 - 0.03 12.9 3.0 0.034 12.7 3.0 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Coilin_N PF15862.5 ETO20782.1 - 0.044 13.6 15.9 0.062 13.1 15.9 1.3 1 0 0 1 1 1 0 Coilin N-terminus SspB PF04386.13 ETO20782.1 - 0.049 13.5 7.1 0.062 13.2 7.1 1.1 1 0 0 1 1 1 0 Stringent starvation protein B RR_TM4-6 PF06459.12 ETO20782.1 - 0.16 11.8 17.0 0.17 11.7 17.0 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO20782.1 - 0.31 9.3 14.3 0.32 9.2 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 ETO20782.1 - 0.31 11.2 6.7 0.32 11.1 6.7 1.1 1 0 0 1 1 1 0 DDHD domain Zip PF02535.22 ETO20782.1 - 0.35 10.0 4.3 0.37 10.0 4.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter EIIBC-GUT_N PF03612.14 ETO20782.1 - 0.6 9.8 9.0 0.8 9.4 9.0 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF4776 PF16003.5 ETO20782.1 - 0.7 8.8 18.8 0.77 8.7 18.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) SpoIIP PF07454.11 ETO20782.1 - 0.71 9.3 13.6 0.85 9.0 13.6 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) YqfQ PF14181.6 ETO20782.1 - 0.98 9.6 17.4 1.2 9.4 17.4 1.1 1 0 0 1 1 1 0 YqfQ-like protein Serinc PF03348.15 ETO20782.1 - 0.98 8.3 4.8 1.1 8.1 4.8 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) Folate_carrier PF01770.18 ETO20782.1 - 1.3 7.7 5.4 1.5 7.5 5.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier DUF789 PF05623.12 ETO20782.1 - 1.3 8.6 7.1 1.5 8.5 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF789) EOS1 PF12326.8 ETO20782.1 - 1.6 8.6 5.4 1.9 8.4 5.4 1.2 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 ETO20782.1 - 2.1 8.4 5.5 2 8.4 5.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO20782.1 - 2.4 6.9 11.5 2.5 6.7 11.5 1.1 1 0 0 1 1 1 0 Presenilin TMEM214 PF10151.9 ETO20782.1 - 4.1 5.7 14.3 4.7 5.5 14.3 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator FAM176 PF14851.6 ETO20782.1 - 5.1 6.7 10.0 7.4 6.2 10.0 1.2 1 0 0 1 1 1 0 FAM176 family PTPRCAP PF15713.5 ETO20782.1 - 5.4 7.3 14.0 8.1 6.7 14.0 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Proton_antipo_C PF01010.19 ETO20782.1 - 6 6.4 7.0 7.8 6.0 7.0 1.2 1 0 0 1 1 1 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus DUF2828 PF11443.8 ETO20782.1 - 7.1 4.6 16.0 7.8 4.5 16.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Cytomega_UL84 PF06284.11 ETO20782.1 - 8.2 4.8 7.3 9.5 4.5 7.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PIP5K PF01504.18 ETO20783.1 - 1.8e-55 188.1 0.6 2.7e-55 187.5 0.6 1.2 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PIP5K PF01504.18 ETO20784.1 - 2.6e-11 43.3 0.9 3.4e-11 42.9 0.9 1.3 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Dicty_REP PF05086.12 ETO20784.1 - 7 4.5 11.1 8.9 4.2 11.1 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Drf_GBD PF06371.13 ETO20785.1 - 9e-20 71.0 1.3 2e-19 69.9 1.3 1.6 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain PH PF00169.29 ETO20785.1 - 5.1e-06 27.0 1.2 2.2e-05 24.9 0.1 2.4 2 0 0 2 2 2 1 PH domain YL1 PF05764.13 ETO20785.1 - 0.0011 19.1 1.5 0.0011 19.1 1.5 1.6 2 0 0 2 2 2 1 YL1 nuclear protein DUF3361 PF11841.8 ETO20785.1 - 0.0032 17.4 0.4 0.15 12.0 0.0 3.3 3 1 0 3 3 3 1 Domain of unknown function (DUF3361) Sigma70_ner PF04546.13 ETO20785.1 - 0.02 14.8 4.7 0.045 13.6 4.7 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region CENP-B_dimeris PF09026.10 ETO20785.1 - 0.027 14.9 0.0 0.027 14.9 0.0 2.4 1 1 1 2 2 1 0 Centromere protein B dimerisation domain CDC45 PF02724.14 ETO20785.1 - 0.029 12.7 6.8 0.046 12.0 6.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO20785.1 - 0.04 12.0 7.6 0.062 11.4 7.6 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Utp14 PF04615.13 ETO20785.1 - 0.57 8.7 11.0 0.87 8.1 11.0 1.2 1 0 0 1 1 1 0 Utp14 protein Nop14 PF04147.12 ETO20785.1 - 2.1 6.5 16.2 3.4 5.8 16.2 1.2 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO20785.1 - 4.3 6.7 15.2 7.1 5.9 15.2 1.2 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.6 ETO20785.1 - 5.4 6.7 8.4 12 5.5 8.4 1.5 1 0 0 1 1 1 0 FAM176 family FPL PF09758.9 ETO20786.1 - 2.7e-66 222.1 10.7 5.5e-66 221.1 10.1 1.7 2 0 0 2 2 2 1 Uncharacterised conserved protein DUF3909 PF13077.6 ETO20786.1 - 0.0078 16.4 2.4 0.36 11.0 0.0 3.1 2 1 0 3 3 3 1 Protein of unknown function (DUF3909) RAI16-like PF10257.9 ETO20786.1 - 0.031 13.2 0.7 0.079 11.8 0.7 1.8 1 1 0 1 1 1 0 Retinoic acid induced 16-like protein SPX PF03105.19 ETO20787.1 - 0.0035 17.3 8.3 0.0046 16.9 8.3 1.0 1 0 0 1 1 1 1 SPX domain DUF4834 PF16118.5 ETO20787.1 - 0.046 14.7 8.8 1.9 9.5 7.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) NOA36 PF06524.12 ETO20787.1 - 0.14 11.5 7.7 0.015 14.6 3.6 1.4 2 0 0 2 2 2 0 NOA36 protein Peroxin-13_N PF04088.13 ETO20787.1 - 0.16 12.2 5.0 1.5 9.0 1.1 2.2 2 0 0 2 2 2 0 Peroxin 13, N-terminal region RNA_pol_Rpc4 PF05132.14 ETO20787.1 - 0.28 11.6 3.5 2.6 8.5 2.9 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 Striatin PF08232.12 ETO20787.1 - 0.5 11.0 10.5 0.57 10.8 6.2 2.0 2 0 0 2 2 2 0 Striatin family Connexin PF00029.19 ETO20787.1 - 0.59 9.8 6.9 4.5 7.0 0.0 2.1 1 1 1 2 2 2 0 Connexin Di19_C PF14571.6 ETO20787.1 - 0.93 10.1 15.8 2.7 8.6 8.3 2.2 2 0 0 2 2 2 0 Stress-induced protein Di19, C-terminal Gti1_Pac2 PF09729.9 ETO20787.1 - 1.6 8.8 12.9 3.2 7.8 10.5 1.9 2 0 0 2 2 2 0 Gti1/Pac2 family AAR2 PF05282.11 ETO20787.1 - 2.6 7.3 9.3 8.7 5.6 6.9 2.0 2 0 0 2 2 2 0 AAR2 protein MMU163 PF17119.5 ETO20787.1 - 3 6.9 7.1 3.3 6.8 3.7 2.1 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis DUF2076 PF09849.9 ETO20787.1 - 3.9 7.5 16.9 0.23 11.5 11.6 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) CSG2 PF16965.5 ETO20787.1 - 5.8 5.7 8.5 7.5 5.4 5.8 1.9 2 0 0 2 2 2 0 Ceramide synthase regulator DUF4820 PF16091.5 ETO20787.1 - 6.3 6.1 11.8 4.3 6.6 7.7 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Podoplanin PF05808.11 ETO20787.1 - 9.8 6.3 6.8 13 5.9 0.0 2.1 2 0 0 2 2 2 0 Podoplanin WD40 PF00400.32 ETO20788.1 - 8.9e-14 51.7 16.2 0.00028 21.6 0.5 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO20788.1 - 2.4e-05 23.2 3.8 0.053 12.2 0.2 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO20788.1 - 3.4e-05 24.1 0.5 1.3 9.4 0.0 4.2 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO20788.1 - 0.036 13.4 0.7 0.072 12.4 0.2 1.8 2 0 0 2 2 2 0 WD40-like domain Peptidase_C14 PF00656.22 ETO20793.1 - 1.3e-17 64.6 1.6 2.2e-17 63.8 1.6 1.3 1 0 0 1 1 1 1 Caspase domain ANAPC3 PF12895.7 ETO20794.1 - 0.0087 16.3 3.0 0.013 15.7 2.9 1.5 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 Fer2_3 PF13085.6 ETO20794.1 - 0.092 12.8 0.1 0.54 10.3 0.1 1.9 1 1 1 2 2 2 0 2Fe-2S iron-sulfur cluster binding domain Pam16 PF03656.13 ETO20794.1 - 0.17 11.9 0.0 0.27 11.2 0.0 1.3 1 0 0 1 1 1 0 Pam16 Choline_transpo PF04515.12 ETO20795.1 - 8.5e-81 271.7 21.5 9.9e-81 271.5 21.5 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter TbpB_C PF17483.2 ETO20796.1 - 1.1 9.7 6.0 1.7 9.1 1.0 2.8 2 1 0 2 2 2 0 C-lobe handle domain of Tf-binding protein B Ras PF00071.22 ETO20797.1 - 1.5e-30 106.0 2.2 1.7e-30 105.8 2.2 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO20797.1 - 9.6e-24 83.9 0.5 1.7e-23 83.1 0.5 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO20797.1 - 1.5e-10 40.9 0.1 2e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO20797.1 - 7.6e-05 22.7 0.0 0.007 16.3 0.1 2.2 2 0 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO20797.1 - 0.00024 21.1 0.0 0.00037 20.5 0.0 1.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ETO20797.1 - 0.0018 18.1 0.7 0.069 12.9 0.1 2.4 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation GTP_EFTU PF00009.27 ETO20797.1 - 0.094 12.2 0.0 0.36 10.3 0.0 1.9 2 0 0 2 2 2 0 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ETO20797.1 - 0.12 11.9 0.0 7.6 6.0 0.0 2.2 3 0 0 3 3 3 0 Ferrous iron transport protein B B56 PF01603.20 ETO20798.1 - 3.6e-161 536.8 12.3 5.5e-161 536.2 12.3 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) GET2 PF08690.10 ETO20800.1 - 0.0056 16.4 1.4 0.0085 15.8 1.4 1.3 1 1 0 1 1 1 1 GET complex subunit GET2 PIRT PF15099.6 ETO20800.1 - 0.035 13.7 0.2 0.051 13.1 0.2 1.3 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family DUF1676 PF07898.13 ETO20800.1 - 0.12 12.5 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Annexin PF00191.20 ETO20801.1 - 1.3e-24 86.0 0.8 1.7e-06 28.0 0.1 4.2 4 0 0 4 4 4 4 Annexin DUF872 PF05915.12 ETO20803.1 - 0.57 10.4 6.1 9.5 6.4 0.8 2.7 1 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) DUF1689 PF07954.11 ETO20803.1 - 0.58 10.6 1.9 8.5 6.8 1.9 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1689) IBR PF01485.21 ETO20804.1 - 0.00078 19.6 10.2 0.00078 19.6 10.2 3.1 2 1 1 3 3 3 1 IBR domain, a half RING-finger domain zf-RING_5 PF14634.6 ETO20804.1 - 0.011 15.6 8.5 0.011 15.6 8.5 3.2 2 1 0 2 2 2 0 zinc-RING finger domain zf-C2H2_jaz PF12171.8 ETO20804.1 - 0.34 11.2 6.8 0.76 10.1 0.0 3.6 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding Prok-RING_4 PF14447.6 ETO20804.1 - 2 8.4 16.9 0.078 12.9 8.2 2.9 2 1 0 2 2 2 0 Prokaryotic RING finger family 4 Luciferase_cat PF10285.9 ETO20805.1 - 0.1 12.0 0.0 0.32 10.3 0.0 1.7 1 1 1 2 2 2 0 Luciferase catalytic domain HUN PF08729.10 ETO20805.1 - 0.2 11.7 0.7 0.6 10.1 0.1 2.1 2 0 0 2 2 2 0 HPC2 and ubinuclein domain Tetraspanin PF00335.20 ETO20806.1 - 1.7e-19 70.4 17.2 2.2e-19 70.1 17.2 1.1 1 0 0 1 1 1 1 Tetraspanin family SLAC1 PF03595.17 ETO20806.1 - 0.0076 15.6 1.8 0.0076 15.6 1.8 1.9 2 0 0 2 2 2 1 Voltage-dependent anion channel AsmA PF05170.14 ETO20806.1 - 0.052 12.4 0.0 0.052 12.4 0.0 1.7 2 1 1 3 3 3 0 AsmA family Bunya_nucleocap PF00952.17 ETO20806.1 - 0.19 11.7 0.0 0.28 11.2 0.0 1.2 1 0 0 1 1 1 0 Bunyavirus nucleocapsid (N) protein DUF1180 PF06679.12 ETO20806.1 - 1.2 9.6 0.0 1.2 9.6 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1180) DUF3810 PF12725.7 ETO20806.1 - 1.4 8.2 4.6 0.28 10.5 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) TMEM43 PF07787.12 ETO20806.1 - 3.2 7.1 7.2 5 6.4 7.2 1.3 1 0 0 1 1 1 0 Transmembrane protein 43 HEAT_EZ PF13513.6 ETO20807.1 - 8.1e-11 42.2 0.0 8.4e-07 29.4 0.0 2.6 2 0 0 2 2 2 2 HEAT-like repeat HEAT PF02985.22 ETO20807.1 - 0.16 12.3 2.8 3.3 8.2 0.1 3.6 3 0 0 3 3 3 0 HEAT repeat DUF2497 PF10691.9 ETO20808.1 - 0.0032 17.9 0.1 0.7 10.4 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF2497) TFIIE_alpha PF02002.17 ETO20808.1 - 0.028 14.3 6.2 0.61 10.0 0.6 2.7 2 1 1 3 3 3 0 TFIIE alpha subunit APG17 PF04108.12 ETO20808.1 - 0.21 10.6 11.4 0.083 12.0 2.8 2.0 1 1 1 2 2 2 0 Autophagy protein Apg17 Holin_BhlA PF10960.8 ETO20808.1 - 6.2 6.9 15.9 1.2 9.1 0.5 3.2 2 1 0 2 2 2 0 BhlA holin family Ank_2 PF12796.7 ETO20810.1 - 0.0009 19.8 0.1 0.18 12.4 0.0 2.8 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) EntA_Immun PF08951.10 ETO20810.1 - 0.12 12.7 1.0 5.1 7.5 0.0 2.9 2 0 0 2 2 2 0 Enterocin A Immunity CDC45 PF02724.14 ETO20811.1 - 0.015 13.6 13.7 0.008 14.5 12.0 1.5 2 0 0 2 2 2 0 CDC45-like protein Zip PF02535.22 ETO20811.1 - 4.3 6.5 20.1 6.6 5.9 20.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Dsh_C PF12316.8 ETO20811.1 - 6.5 7.1 13.3 10 6.5 13.3 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Podoplanin PF05808.11 ETO20811.1 - 6.7 6.8 7.7 9.9 6.2 7.7 1.2 1 0 0 1 1 1 0 Podoplanin Musclin PF11037.8 ETO20812.1 - 0.33 10.9 3.2 0.63 10.0 0.9 2.0 1 1 1 2 2 2 0 Insulin-resistance promoting peptide in skeletal muscle YL1 PF05764.13 ETO20813.1 - 2.4e-05 24.6 14.1 2.4e-05 24.6 14.1 5.2 4 1 0 4 4 4 2 YL1 nuclear protein Gti1_Pac2 PF09729.9 ETO20813.1 - 0.012 15.7 2.2 0.012 15.7 2.2 7.3 4 2 0 4 4 4 0 Gti1/Pac2 family Kei1 PF08552.11 ETO20813.1 - 1.3 8.8 0.0 1.3 8.8 0.0 6.7 5 2 0 5 5 5 0 Inositolphosphorylceramide synthase subunit Kei1 Med26 PF08711.11 ETO20814.1 - 1.2e-05 25.2 1.6 2.3e-05 24.3 1.6 1.5 1 0 0 1 1 1 1 TFIIS helical bundle-like domain A_deaminase PF00962.22 ETO20815.1 - 3.6e-24 85.7 2.0 5.5e-24 85.1 2.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase zf-RanBP PF00641.18 ETO20817.1 - 9.3e-15 53.6 14.5 9.6e-08 31.2 3.0 2.4 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DUF4650 PF15509.6 ETO20817.1 - 0.0039 16.6 13.2 0.0051 16.2 13.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4650) DZR PF12773.7 ETO20817.1 - 0.031 14.3 6.7 1.5 8.9 0.7 2.3 2 0 0 2 2 2 0 Double zinc ribbon AAA_23 PF13476.6 ETO20817.1 - 0.042 14.4 8.3 0.053 14.0 8.3 1.1 1 0 0 1 1 1 0 AAA domain CCD48 PF15799.5 ETO20817.1 - 0.18 10.1 11.0 0.23 9.7 11.0 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 zf-MIZ PF02891.20 ETO20817.1 - 0.23 11.3 7.9 1.4 8.8 0.4 2.8 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger zf-Sec23_Sec24 PF04810.15 ETO20817.1 - 0.39 10.8 0.1 0.39 10.8 0.1 3.3 3 1 1 4 4 4 0 Sec23/Sec24 zinc finger Vps36-NZF-N PF16988.5 ETO20817.1 - 0.76 9.2 16.2 0.21 11.0 0.6 3.8 2 1 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DUF3523 PF12037.8 ETO20817.1 - 3.2 7.0 21.6 4.3 6.6 21.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) Rubredoxin PF00301.20 ETO20817.1 - 4.2 7.5 9.0 9.7 6.3 0.2 3.0 2 1 1 3 3 3 0 Rubredoxin DUF4407 PF14362.6 ETO20817.1 - 5.1 6.4 9.0 6.4 6.0 9.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Ras PF00071.22 ETO20818.1 - 2.6e-49 166.9 0.2 3.5e-49 166.5 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO20818.1 - 6.9e-26 90.8 0.1 1.3e-25 89.9 0.1 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO20818.1 - 7.5e-12 45.0 0.0 9.8e-12 44.7 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO20818.1 - 0.0031 17.6 0.0 0.0049 16.9 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO20818.1 - 0.023 14.0 0.1 0.039 13.3 0.1 1.4 1 1 0 1 1 1 0 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO20818.1 - 0.063 12.8 0.0 0.14 11.7 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Psb28 PF03912.14 ETO20818.1 - 0.12 12.6 0.1 0.38 11.1 0.0 1.8 2 0 0 2 2 2 0 Psb28 protein PRP38 PF03371.15 ETO20820.1 - 8.7e-42 142.9 0.1 4.5e-35 121.1 0.1 2.2 2 0 0 2 2 2 2 PRP38 family Tudor-knot PF11717.8 ETO20820.1 - 0.12 12.3 0.0 0.21 11.5 0.0 1.5 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain PEPCK_ATP PF01293.20 ETO20822.1 - 5.2e-160 533.1 0.0 5.8e-160 533.0 0.0 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase AAA_16 PF13191.6 ETO20822.1 - 0.013 15.9 0.0 0.018 15.4 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Orf78 PF06024.12 ETO20823.1 - 0.046 14.0 4.6 0.11 12.8 0.3 3.0 3 1 0 3 3 3 0 Orf78 (ac78) Pex2_Pex12 PF04757.14 ETO20823.1 - 2.8 7.5 14.4 0.41 10.2 2.7 2.4 1 1 1 2 2 2 0 Pex2 / Pex12 amino terminal region BatD PF13584.6 ETO20823.1 - 6.6 5.4 7.6 4.6 5.9 5.2 1.9 2 1 0 2 2 2 0 Oxygen tolerance GGDEF PF00990.21 ETO20824.1 - 0.0015 18.3 0.0 0.0042 16.9 0.0 1.7 1 1 0 1 1 1 1 Diguanylate cyclase, GGDEF domain DUF4386 PF14329.6 ETO20826.1 - 0.028 14.3 0.1 0.037 13.9 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4386) AMP-binding PF00501.28 ETO20828.1 - 2.7e-39 135.0 0.0 3.7e-39 134.5 0.0 1.2 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO20828.1 - 3.1e-05 24.8 0.1 0.041 14.8 0.0 2.7 2 0 0 2 2 2 2 AMP-binding enzyme C-terminal domain ACAS_N PF16177.5 ETO20828.1 - 0.0023 17.8 0.2 0.036 14.0 0.1 2.3 2 0 0 2 2 2 1 Acetyl-coenzyme A synthetase N-terminus Proteasome PF00227.26 ETO20829.1 - 9.9e-13 48.0 0.1 1.4e-12 47.5 0.1 1.3 1 1 0 1 1 1 1 Proteasome subunit ADIP PF11559.8 ETO20830.1 - 0.0098 16.0 18.1 0.0098 16.0 18.1 4.4 2 2 3 5 5 5 2 Afadin- and alpha -actinin-Binding FUSC PF04632.12 ETO20830.1 - 1.9 6.9 7.6 0.59 8.6 4.7 1.5 2 0 0 2 2 2 0 Fusaric acid resistance protein family EF-hand_1 PF00036.32 ETO20831.1 - 2.1e-11 42.5 2.6 4e-06 26.0 1.2 2.4 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO20831.1 - 6.3e-11 42.6 0.4 0.00045 20.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO20831.1 - 2.3e-10 40.1 0.6 0.00054 19.8 0.3 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO20831.1 - 7.3e-09 34.9 1.7 0.0041 16.9 0.1 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO20831.1 - 1e-06 27.9 2.7 0.029 13.9 0.1 2.4 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 ETO20831.1 - 7.2e-05 23.1 0.2 0.00011 22.5 0.2 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETO20831.1 - 0.00033 20.9 0.3 0.67 10.3 0.2 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETO20831.1 - 0.0082 16.1 1.1 0.22 11.5 0.3 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand EF-hand_11 PF08976.11 ETO20831.1 - 0.22 12.4 0.6 0.35 11.8 0.1 1.6 2 0 0 2 2 2 0 EF-hand domain DUF1282 PF06930.12 ETO20834.1 - 0.017 14.9 12.1 0.44 10.3 12.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1282) Hydrolase_4 PF12146.8 ETO20835.1 - 4.7e-14 52.2 0.0 1.1e-08 34.6 0.0 2.2 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETO20835.1 - 1.5e-08 34.4 0.0 1e-07 31.6 0.0 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETO20835.1 - 9.9e-07 28.8 0.1 0.00014 21.8 0.1 3.0 1 1 1 2 2 2 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 ETO20835.1 - 4.7e-06 26.6 0.0 7.7e-06 25.9 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold DUF818 PF05677.12 ETO20835.1 - 1.3e-05 24.4 0.0 2e-05 23.7 0.0 1.2 1 0 0 1 1 1 1 Chlamydia CHLPS protein (DUF818) Abhydrolase_6 PF12697.7 ETO20835.1 - 2.3e-05 25.1 0.0 0.00037 21.2 0.0 2.0 1 1 1 2 2 2 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETO20835.1 - 8.9e-05 22.2 0.0 0.15 11.7 0.1 2.2 1 1 1 2 2 2 2 alpha/beta hydrolase fold DUF1749 PF08538.10 ETO20835.1 - 0.00015 21.0 0.0 0.00022 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1749) FSH1 PF03959.13 ETO20835.1 - 0.00059 19.6 1.6 0.0032 17.1 0.0 2.6 2 1 2 4 4 4 1 Serine hydrolase (FSH1) DLH PF01738.18 ETO20835.1 - 0.0019 17.8 0.0 0.0046 16.5 0.0 1.6 1 1 0 1 1 1 1 Dienelactone hydrolase family LIP PF03583.14 ETO20835.1 - 0.0026 17.1 0.0 0.083 12.2 0.0 2.2 2 0 0 2 2 2 1 Secretory lipase BAAT_C PF08840.11 ETO20835.1 - 0.034 14.1 0.0 7.1 6.5 0.0 2.3 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal 3HBOH PF10605.9 ETO20835.1 - 0.16 10.1 0.0 1.6 6.8 0.0 2.0 2 0 0 2 2 2 0 3HB-oligomer hydrolase (3HBOH) SARAF PF06682.12 ETO20837.1 - 0.091 12.4 17.2 0.12 12.0 17.2 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Vfa1 PF08432.10 ETO20837.1 - 2.1 8.7 24.0 2.9 8.2 0.5 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Macoilin PF09726.9 ETO20837.1 - 6.8 5.1 27.7 8.7 4.8 27.7 1.1 1 0 0 1 1 1 0 Macoilin family Utp14 PF04615.13 ETO20837.1 - 7.8 4.9 26.9 9.5 4.7 26.9 1.1 1 0 0 1 1 1 0 Utp14 protein FAM176 PF14851.6 ETO20837.1 - 7.9 6.1 12.8 6.3 6.4 4.3 2.3 2 0 0 2 2 2 0 FAM176 family ADK PF00406.22 ETO20838.1 - 3.2e-29 102.0 0.3 8.3e-29 100.6 0.3 1.6 1 1 0 1 1 1 1 Adenylate kinase ADK_lid PF05191.14 ETO20838.1 - 9e-15 54.4 1.1 1.2e-14 54.0 0.0 1.8 2 0 0 2 2 2 1 Adenylate kinase, active site lid AAA_17 PF13207.6 ETO20838.1 - 0.00031 21.2 1.4 0.0005 20.5 0.1 1.9 3 0 0 3 3 3 1 AAA domain Bystin PF05291.11 ETO20838.1 - 0.0055 16.0 0.1 0.094 12.0 0.0 2.0 2 0 0 2 2 2 1 Bystin SDA1 PF05285.12 ETO20840.1 - 1.1 8.6 12.6 1.7 8.0 12.6 1.3 1 0 0 1 1 1 0 SDA1 Acyl-ACP_TE PF01643.17 ETO20841.1 - 0.098 11.9 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Acyl-ACP thioesterase DEAD PF00270.29 ETO20843.1 - 3e-12 46.7 0.6 1.3e-09 38.1 0.3 3.1 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO20843.1 - 6e-05 23.1 1.8 0.00015 21.8 0.0 2.6 3 1 0 3 3 3 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO20843.1 - 0.0018 18.6 0.1 0.051 13.9 0.1 2.5 1 1 0 1 1 1 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ETO20843.1 - 0.0041 17.4 0.1 0.022 15.0 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETO20843.1 - 0.025 15.0 0.2 0.12 12.8 0.2 2.1 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) BTB PF00651.31 ETO20844.1 - 1.5e-13 50.9 0.3 4e-13 49.6 0.3 1.8 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ETO20844.1 - 0.005 16.9 0.7 0.015 15.4 0.2 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch Neil1-DNA_bind PF09292.10 ETO20844.1 - 0.033 14.2 0.4 0.079 12.9 0.4 1.6 1 0 0 1 1 1 0 Endonuclease VIII-like 1, DNA bind DUF3748 PF12566.8 ETO20845.1 - 0.051 13.5 0.1 0.38 10.7 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3748) PIG-P PF08510.12 ETO20845.1 - 0.086 12.8 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 PIG-P ANAPC8 PF04049.13 ETO20846.1 - 4.6e-12 46.2 0.6 6.3e-12 45.7 0.6 1.2 1 0 0 1 1 1 1 Anaphase promoting complex subunit 8 / Cdc23 ECF_trnsprt PF12822.7 ETO20846.1 - 0.065 13.3 4.8 0.077 13.1 4.8 1.1 1 0 0 1 1 1 0 ECF transporter, substrate-specific component DUF1980 PF09323.10 ETO20846.1 - 3.8 7.4 15.3 0.034 14.1 4.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1980) Peptidase_M42 PF05343.14 ETO20847.1 - 0.024 13.7 0.0 0.025 13.6 0.0 1.1 1 0 0 1 1 1 0 M42 glutamyl aminopeptidase Actin PF00022.19 ETO20847.1 - 0.055 12.1 0.0 0.061 11.9 0.0 1.1 1 0 0 1 1 1 0 Actin Beta-APP PF03494.13 ETO20847.1 - 0.057 13.3 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Beta-amyloid peptide (beta-APP) Mtd_N PF18454.1 ETO20847.1 - 0.1 12.6 0.0 0.23 11.5 0.0 1.6 1 0 0 1 1 1 0 Major tropism determinant N-terminal domain Tcf25 PF04910.14 ETO20848.1 - 1.7e-69 234.6 3.1 2.3e-69 234.1 3.1 1.1 1 0 0 1 1 1 1 Transcriptional repressor TCF25 YdjM PF04307.14 ETO20848.1 - 0.19 11.1 0.4 0.47 9.7 0.4 1.5 1 1 0 1 1 1 0 LexA-binding, inner membrane-associated putative hydrolase Laminin_II PF06009.12 ETO20849.1 - 0.0024 17.9 3.2 0.0037 17.3 3.2 1.3 1 0 0 1 1 1 1 Laminin Domain II DUF4756 PF15948.5 ETO20849.1 - 0.016 15.1 0.7 0.025 14.5 0.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4756) FAM76 PF16046.5 ETO20849.1 - 0.03 13.7 0.2 0.043 13.2 0.2 1.3 1 0 0 1 1 1 0 FAM76 protein Pox_A_type_inc PF04508.12 ETO20849.1 - 0.15 12.0 0.2 0.35 10.8 0.2 1.6 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat Fib_alpha PF08702.10 ETO20849.1 - 0.18 12.0 5.6 0.31 11.2 5.6 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Syntaxin_2 PF14523.6 ETO20849.1 - 0.25 11.7 7.7 0.52 10.7 7.7 1.5 1 0 0 1 1 1 0 Syntaxin-like protein DUF745 PF05335.13 ETO20849.1 - 0.26 11.0 1.7 0.42 10.3 1.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF745) Med4 PF10018.9 ETO20849.1 - 0.35 10.5 5.6 0.68 9.6 5.6 1.5 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 CENP-B_dimeris PF09026.10 ETO20850.1 - 0.015 15.7 5.2 0.015 15.7 5.2 4.0 2 1 0 2 2 2 0 Centromere protein B dimerisation domain Pkinase PF00069.25 ETO20851.1 - 3.4e-57 193.8 0.2 1.4e-56 191.8 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20851.1 - 5.9e-27 94.6 0.0 1.6e-26 93.1 0.0 1.8 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 ETO20851.1 - 1.4e-18 66.7 0.0 1.1e-11 44.6 0.0 3.8 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain Nop53 PF07767.11 ETO20851.1 - 9.3 5.5 42.0 0.0084 15.6 22.2 2.6 3 0 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) Ion_trans PF00520.31 ETO20852.1 - 3.6e-16 59.1 5.1 5.2e-16 58.6 5.1 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO20852.1 - 0.00028 19.7 0.2 0.00042 19.1 0.2 1.3 1 0 0 1 1 1 1 Polycystin cation channel Ion_trans PF00520.31 ETO20853.1 - 2.5e-49 167.7 24.9 1.6e-31 109.4 12.1 2.4 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 ETO20853.1 - 1.3e-05 24.0 2.4 1.3e-05 24.0 2.4 4.1 3 2 1 5 5 5 3 Polycystin cation channel Ion_trans PF00520.31 ETO20854.1 - 5.9e-10 38.8 0.5 7.3e-10 38.5 0.5 1.1 1 0 0 1 1 1 1 Ion transport protein LPD30 PF18850.1 ETO20854.1 - 0.092 12.5 1.3 0.13 12.0 1.3 1.3 1 0 0 1 1 1 0 Large polyvalent protein associated domain 30 ETRAMP PF09716.10 ETO20854.1 - 0.29 11.2 3.6 1.3 9.1 0.2 2.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ion_trans PF00520.31 ETO20855.1 - 4.2e-29 101.5 29.3 9.5e-29 100.3 29.3 1.5 1 1 0 1 1 1 1 Ion transport protein DUF4901 PF16244.5 ETO20855.1 - 0.5 9.7 4.7 2.9 7.2 4.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4901) BUD22 PF09073.10 ETO20857.1 - 0.93 8.8 27.1 0.061 12.7 22.2 1.4 2 0 0 2 2 2 0 BUD22 Nop14 PF04147.12 ETO20857.1 - 1.3 7.1 28.4 0.056 11.7 22.3 1.6 2 0 0 2 2 2 0 Nop14-like family Guanylate_cyc PF00211.20 ETO20859.1 - 7.9e-16 58.2 0.0 2e-10 40.6 0.0 3.1 2 1 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain DUF4903 PF16246.5 ETO20859.1 - 0.16 11.6 1.2 0.31 10.6 0.3 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4903) DUF4768 PF15989.5 ETO20859.1 - 0.19 11.7 0.3 0.48 10.4 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4768) Strep_SA_rep PF06696.11 ETO20859.1 - 3.4 7.8 7.3 6.9 6.8 7.3 1.5 1 0 0 1 1 1 0 Streptococcal surface antigen repeat Kinesin PF00225.23 ETO20860.1 - 1.4e-12 47.2 3.6 1.6e-11 43.7 3.6 2.1 1 1 0 1 1 1 1 Kinesin motor domain CdiA_C PF18451.1 ETO20860.1 - 0.055 13.7 0.6 0.35 11.1 0.0 2.7 3 0 0 3 3 3 0 Contact-dependent growth inhibition CdiA C-terminal domain SPOUT_MTase PF02590.17 ETO20860.1 - 2.1 8.3 5.9 1.5 8.8 0.3 3.0 2 2 1 3 3 3 0 Predicted SPOUT methyltransferase PH_BEACH PF14844.6 ETO20861.1 - 0.11 12.6 0.1 0.24 11.5 0.1 1.6 1 0 0 1 1 1 0 PH domain associated with Beige/BEACH CobT PF06213.12 ETO20861.1 - 0.38 10.1 10.9 16 4.7 10.9 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Lin-8 PF03353.15 ETO20861.1 - 0.95 9.0 13.5 0.67 9.5 1.3 2.1 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Pap_E4 PF02711.14 ETO20861.1 - 2.2 9.3 10.3 6.6 7.8 0.9 3.1 3 0 0 3 3 3 0 E4 protein Sec62 PF03839.16 ETO20861.1 - 2.7 7.4 4.2 5.3 6.5 4.2 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 TFB6 PF17110.5 ETO20861.1 - 3.8 7.2 6.3 6.7 6.4 6.3 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH ORF6C PF10552.9 ETO20862.1 - 0.029 14.4 0.1 0.042 13.9 0.1 1.2 1 0 0 1 1 1 0 ORF6C domain zf-C3HC4 PF00097.25 ETO20862.1 - 0.1 12.5 1.3 0.19 11.6 0.7 1.8 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO20862.1 - 0.11 12.3 2.9 0.26 11.0 1.6 2.3 2 0 0 2 2 2 0 RING-like zinc finger zf-RING_5 PF14634.6 ETO20862.1 - 0.11 12.5 0.4 0.19 11.7 0.4 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Paramyxo_P_V_N PF13825.6 ETO20862.1 - 0.16 11.4 2.5 0.21 11.0 2.5 1.2 1 0 0 1 1 1 0 Paramyxovirus structural protein V/P N-terminus DUF846 PF05832.12 ETO20863.1 - 8.5e-46 155.4 13.6 8.5e-46 155.4 13.6 2.1 1 1 1 2 2 2 2 Eukaryotic protein of unknown function (DUF846) PROCN PF08083.11 ETO20865.1 - 1.2e-233 775.1 8.3 2e-233 774.4 8.3 1.3 1 0 0 1 1 1 1 PROCN (NUC071) domain PRP8_domainIV PF12134.8 ETO20865.1 - 3.3e-125 416.3 0.5 6.6e-125 415.3 0.5 1.5 1 0 0 1 1 1 1 PRP8 domain IV core U6-snRNA_bdg PF10596.9 ETO20865.1 - 3.3e-89 296.9 2.9 8.5e-89 295.6 2.9 1.8 1 0 0 1 1 1 1 U6-snRNA interacting domain of PrP8 U5_2-snRNA_bdg PF10597.9 ETO20865.1 - 3.8e-70 234.2 0.0 7.7e-70 233.2 0.0 1.5 1 0 0 1 1 1 1 U5-snRNA binding site 2 of PrP8 PROCT PF08084.11 ETO20865.1 - 1.3e-45 154.3 1.8 1.3e-45 154.2 0.2 1.8 2 0 0 2 2 2 1 PROCT (NUC072) domain RRM_4 PF10598.9 ETO20865.1 - 4.4e-44 148.7 0.1 1.3e-43 147.2 0.1 1.9 1 0 0 1 1 1 1 RNA recognition motif of the spliceosomal PrP8 JAB PF01398.21 ETO20865.1 - 5.6e-05 23.1 0.0 0.001 19.0 0.0 2.8 3 0 0 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Ni_hydr_CYTB PF01292.20 ETO20867.1 - 0.054 13.1 0.1 0.065 12.8 0.1 1.3 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 LSM PF01423.22 ETO20868.1 - 2.5e-13 49.5 0.6 5.9e-13 48.3 0.1 1.8 2 0 0 2 2 2 1 LSM domain Csm2_III-A PF03750.13 ETO20869.1 - 0.43 11.4 6.1 0.75 10.6 6.1 1.4 1 0 0 1 1 1 0 Csm2 Type III-A TPR_14 PF13428.6 ETO20870.1 - 0.00011 22.7 8.8 39 5.4 0.2 8.7 11 0 0 11 11 10 0 Tetratricopeptide repeat PPR PF01535.20 ETO20870.1 - 0.00013 22.0 4.0 3.5 8.1 0.0 5.9 5 0 0 5 5 5 2 PPR repeat Clathrin PF00637.20 ETO20870.1 - 0.0024 17.8 29.4 0.9 9.4 0.4 8.0 4 2 2 7 7 7 3 Region in Clathrin and VPS PPR_2 PF13041.6 ETO20870.1 - 0.0087 16.2 0.1 1.1 9.5 0.0 3.8 2 0 0 2 2 2 1 PPR repeat family TPR_2 PF07719.17 ETO20870.1 - 0.0094 16.0 39.7 1.9 8.8 0.4 11.2 10 2 1 11 11 11 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO20870.1 - 0.017 15.4 20.9 2.8 8.3 0.2 7.8 6 2 1 7 7 7 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO20870.1 - 0.072 13.7 3.3 25 5.6 0.0 5.1 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO20870.1 - 0.3 11.6 16.1 23 5.6 0.1 7.7 6 1 1 7 7 7 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO20870.1 - 0.46 10.7 19.4 1.5 9.1 1.9 7.4 6 3 3 9 9 9 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ETO20870.1 - 0.56 10.4 24.6 25 5.2 0.1 9.4 9 2 0 9 9 9 0 Tetratricopeptide repeat YhdB PF14148.6 ETO20870.1 - 1.6 8.9 5.4 3.2 7.9 0.1 3.8 2 1 1 3 3 3 0 YhdB-like protein NRBF2_MIT PF17169.4 ETO20870.1 - 2.1 8.6 14.0 0.2 11.9 0.4 4.2 4 1 1 5 5 5 0 MIT domain of nuclear receptor-binding factor 2 TPR_1 PF00515.28 ETO20870.1 - 3.9 7.5 41.7 13 5.8 0.1 11.2 11 1 1 12 12 12 0 Tetratricopeptide repeat Heme_oxygenase PF01126.20 ETO20871.1 - 0.05 13.4 0.1 0.063 13.1 0.1 1.2 1 0 0 1 1 1 0 Heme oxygenase FH2 PF02181.23 ETO20872.1 - 1.3e-08 34.4 3.6 1.3e-08 34.4 3.6 2.7 2 0 0 2 2 2 1 Formin Homology 2 Domain PH PF00169.29 ETO20872.1 - 2e-05 25.0 0.2 0.00028 21.4 0.1 2.9 2 0 0 2 2 2 1 PH domain DUF3973 PF13119.6 ETO20872.1 - 0.1 12.7 1.0 0.26 11.4 1.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3973) CAP_GLY PF01302.25 ETO20873.1 - 3.7e-07 30.1 1.1 7.3e-07 29.1 1.1 1.6 1 0 0 1 1 1 1 CAP-Gly domain UPF0254 PF06787.11 ETO20874.1 - 0.062 13.1 0.1 0.11 12.3 0.0 1.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0254) CENP-B_dimeris PF09026.10 ETO20875.1 - 2.2 8.7 7.0 6.7 7.2 7.0 1.9 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PRIMA1 PF16101.5 ETO20875.1 - 8.8 6.4 11.6 16 5.6 2.6 2.7 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 zf_CCCH_4 PF18345.1 ETO20876.1 - 0.75 9.9 6.5 1.5 8.9 6.5 1.6 1 0 0 1 1 1 0 Zinc finger domain MCM PF00493.23 ETO20877.1 - 1.5e-83 279.4 0.2 6e-74 247.9 0.0 2.3 2 0 0 2 2 2 2 MCM P-loop domain MCM_OB PF17207.3 ETO20877.1 - 2.6e-25 88.7 0.9 4.9e-25 87.8 0.9 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETO20877.1 - 4.1e-24 84.8 0.8 8.1e-24 83.9 0.8 1.5 1 0 0 1 1 1 1 MCM AAA-lid domain Mg_chelatase PF01078.21 ETO20877.1 - 1.6e-09 37.5 0.3 1.4e-06 27.8 0.0 2.4 1 1 1 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETO20877.1 - 1.7e-09 37.8 0.0 3.6e-09 36.8 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ETO20877.1 - 1.1e-06 28.5 0.0 3e-06 27.1 0.0 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ETO20877.1 - 0.00046 20.6 0.2 0.0019 18.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETO20877.1 - 0.00051 19.8 0.0 0.17 11.6 0.0 2.4 2 0 0 2 2 2 1 Sigma-54 interaction domain RuvB_N PF05496.12 ETO20877.1 - 0.0028 17.4 0.0 0.0069 16.1 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain SusD_RagB PF07980.11 ETO20877.1 - 0.023 14.3 15.2 0.12 11.9 2.8 2.6 2 0 0 2 2 2 0 SusD family AAA_22 PF13401.6 ETO20877.1 - 0.053 13.8 0.5 0.5 10.6 0.0 2.7 2 1 1 3 3 3 0 AAA domain NTPase_1 PF03266.15 ETO20877.1 - 0.055 13.4 0.2 2.1 8.2 0.0 2.6 1 1 1 2 2 2 0 NTPase AAA_16 PF13191.6 ETO20877.1 - 0.1 13.0 0.0 0.57 10.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Sigma54_activ_2 PF14532.6 ETO20877.1 - 0.13 12.4 0.3 3 8.0 0.0 3.2 3 1 0 3 3 3 0 Sigma-54 interaction domain DUF4834 PF16118.5 ETO20877.1 - 0.37 11.8 14.2 0.11 13.4 1.6 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) MID_MedPIWI PF18296.1 ETO20877.1 - 1.3 8.8 12.6 1.1 8.9 2.3 3.1 3 0 0 3 3 3 0 MID domain of medPIWI Gti1_Pac2 PF09729.9 ETO20877.1 - 2.2 8.3 15.2 2.5 8.1 3.5 3.2 3 0 0 3 3 3 0 Gti1/Pac2 family Menin PF05053.13 ETO20877.1 - 2.8 6.2 19.4 1.8 6.9 9.7 2.2 2 0 0 2 2 2 0 Menin Presenilin PF01080.17 ETO20877.1 - 3 6.5 6.6 0.41 9.4 0.3 2.2 2 0 0 2 2 2 0 Presenilin Ras PF00071.22 ETO20878.1 - 2.4e-24 85.8 0.2 3.1e-24 85.4 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO20878.1 - 1.8e-05 24.9 0.1 6.6e-05 23.1 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO20878.1 - 0.016 14.7 0.0 0.021 14.3 0.0 1.1 1 0 0 1 1 1 0 ADP-ribosylation factor family RhoGAP PF00620.27 ETO20880.1 - 3.3e-18 66.0 0.0 1.4e-14 54.2 0.0 2.3 2 0 0 2 2 2 2 RhoGAP domain PBD PF00786.28 ETO20880.1 - 0.0016 18.8 0.0 0.0046 17.3 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain Tmemb_9 PF05434.11 ETO20880.1 - 0.074 12.9 2.0 0.13 12.2 2.0 1.4 1 0 0 1 1 1 0 TMEM9 Apo-VLDL-II PF05418.11 ETO20880.1 - 0.077 13.6 0.4 0.39 11.3 0.1 2.3 1 1 1 2 2 2 0 Apovitellenin I (Apo-VLDL-II) ApoL PF05461.11 ETO20882.1 - 0.12 11.7 0.2 0.13 11.6 0.2 1.2 1 0 0 1 1 1 0 Apolipoprotein L DUF3439 PF11921.8 ETO20883.1 - 0.018 15.0 2.3 0.037 14.0 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ETRAMP PF09716.10 ETO20883.1 - 1 9.5 3.1 0.3 11.2 0.1 1.8 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) FAM176 PF14851.6 ETO20883.1 - 2.3 7.9 7.8 4 7.1 3.2 2.3 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 ETO20884.1 - 0.29 10.4 24.4 0.33 10.2 24.4 1.0 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETO20884.1 - 0.78 8.0 16.7 0.95 7.7 16.7 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO20884.1 - 3.2 7.1 30.5 4.2 6.7 30.5 1.1 1 0 0 1 1 1 0 SDA1 MOR2-PAG1_C PF14225.6 ETO20886.1 - 7.1e-09 35.9 0.0 3.1e-08 33.8 0.0 2.1 2 0 0 2 2 2 1 Cell morphogenesis C-terminal DUF1600 PF07667.11 ETO20886.1 - 0.026 14.7 0.2 0.11 12.7 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) DNA_pol_phi PF04931.13 ETO20887.1 - 0.0032 15.7 1.0 0.0032 15.7 1.0 1.6 2 0 0 2 2 2 1 DNA polymerase phi AF-4 PF05110.13 ETO20887.1 - 0.012 13.7 0.6 0.015 13.4 0.6 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Menin PF05053.13 ETO20888.1 - 0.17 10.2 2.4 0.17 10.2 2.4 1.1 1 0 0 1 1 1 0 Menin LIN52 PF10044.9 ETO20888.1 - 0.32 11.7 2.2 21 5.9 0.1 2.2 2 0 0 2 2 2 0 Retinal tissue protein Mer2 PF09074.10 ETO20890.1 - 0.02 14.7 1.6 0.024 14.4 1.6 1.2 1 0 0 1 1 1 0 Mer2 AAA_34 PF13872.6 ETO20890.1 - 0.038 12.9 0.4 0.05 12.5 0.4 1.2 1 0 0 1 1 1 0 P-loop containing NTP hydrolase pore-1 ERp29 PF07749.12 ETO20890.1 - 0.15 13.0 6.1 0.3 12.0 6.1 1.5 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain MDM10 PF12519.8 ETO20890.1 - 1.1 8.1 5.8 1.3 7.8 5.8 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 OmpH PF03938.14 ETO20890.1 - 4.1 7.8 9.4 7.4 6.9 8.7 1.7 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) F-box-like_2 PF13013.6 ETO20892.1 - 0.032 14.2 0.4 0.074 13.0 0.3 1.7 1 1 1 2 2 2 0 F-box-like domain CTC1 PF15489.6 ETO20892.1 - 0.088 10.3 0.3 0.1 10.1 0.3 1.0 1 0 0 1 1 1 0 CST, telomere maintenance, complex subunit CTC1 DUF3492 PF11997.8 ETO20892.1 - 0.15 11.8 0.7 0.18 11.5 0.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3492) Ion_trans PF00520.31 ETO20893.1 - 1.9e-06 27.3 4.0 2.9e-06 26.7 4.0 1.2 1 0 0 1 1 1 1 Ion transport protein FAM196 PF15265.6 ETO20893.1 - 0.29 10.6 3.9 4.5 6.7 0.4 2.1 2 0 0 2 2 2 0 FAM196 family YAcAr PF10686.9 ETO20894.1 - 0.043 13.8 0.0 0.17 11.8 0.0 2.0 1 0 0 1 1 1 0 YspA, cpYpsA-related SLOG family RNA12 PF10443.9 ETO20894.1 - 0.073 11.8 0.6 0.12 11.1 0.6 1.2 1 0 0 1 1 1 0 RNA12 protein Menin PF05053.13 ETO20894.1 - 3.3 6.0 5.2 4.9 5.4 5.2 1.1 1 0 0 1 1 1 0 Menin CRA PF06589.11 ETO20894.1 - 6.2 6.9 9.7 11 6.1 9.7 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) zf-CCHC PF00098.23 ETO20895.1 - 4e-08 33.0 21.4 0.0022 18.0 3.4 3.7 3 0 0 3 3 3 3 Zinc knuckle zf-CCHC_3 PF13917.6 ETO20895.1 - 0.0005 20.0 31.6 0.0054 16.7 7.5 3.3 2 1 1 3 3 3 2 Zinc knuckle zf-CCHC_2 PF13696.6 ETO20895.1 - 0.012 15.4 4.2 0.012 15.4 4.2 3.5 3 0 0 3 3 3 0 Zinc knuckle Phage_portal PF04860.12 ETO20896.1 - 0.044 13.0 0.1 0.34 10.0 0.0 1.9 2 0 0 2 2 2 0 Phage portal protein TPR_12 PF13424.6 ETO20897.1 - 3.9e-91 299.4 34.2 8e-17 61.3 1.0 7.2 2 2 7 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO20897.1 - 6.4e-58 191.2 9.6 1.6e-07 31.0 0.1 9.6 10 0 0 10 10 9 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO20897.1 - 5.3e-51 168.5 48.8 4.6e-09 35.7 0.2 8.8 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO20897.1 - 1.4e-44 146.9 14.1 1.6e-05 24.6 0.0 9.5 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO20897.1 - 3.7e-39 129.7 38.8 4e-05 23.4 0.1 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO20897.1 - 2.2e-36 121.0 48.0 0.00036 20.5 0.4 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO20897.1 - 5.3e-18 64.0 20.5 0.0022 18.2 0.0 8.9 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO20897.1 - 4.7e-16 58.2 45.0 0.00035 20.2 0.1 10.7 8 2 2 10 10 10 5 TPR repeat TPR_6 PF13174.6 ETO20897.1 - 3.4e-12 46.2 9.2 2.8 8.8 0.0 8.2 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO20897.1 - 1.3e-11 44.3 0.0 0.3 12.0 0.0 7.7 7 1 1 8 8 7 1 Tetratricopeptide repeat PPR PF01535.20 ETO20897.1 - 2.7e-11 42.9 11.3 0.075 13.3 0.3 6.2 5 0 0 5 5 5 3 PPR repeat TPR_16 PF13432.6 ETO20897.1 - 8.1e-11 42.4 0.1 0.73 10.5 0.0 6.6 6 2 0 6 6 6 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO20897.1 - 9.9e-06 25.7 20.6 0.011 16.0 0.8 5.6 4 2 2 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETO20897.1 - 1.1e-05 25.0 0.0 0.15 11.4 0.1 2.9 1 1 1 2 2 2 2 MalT-like TPR region DUF2225 PF09986.9 ETO20897.1 - 1.9e-05 24.5 24.5 0.057 13.1 0.5 5.4 1 1 3 5 5 5 4 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETO20897.1 - 4e-05 23.5 29.8 0.016 15.0 0.3 7.1 4 3 4 8 8 8 2 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO20897.1 - 4.3e-05 23.9 4.4 0.059 13.9 0.1 4.2 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO20897.1 - 4.3e-05 23.4 32.0 0.01 15.8 0.1 6.9 9 0 0 9 9 6 4 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO20897.1 - 5.2e-05 22.6 1.2 4.1 6.9 0.0 5.8 6 0 0 6 6 6 1 SHNi-TPR MIT PF04212.18 ETO20897.1 - 0.00047 20.2 29.7 1.1 9.3 0.2 8.0 8 1 1 9 9 8 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 ETO20897.1 - 0.0065 16.5 2.7 3.1 7.9 0.2 3.9 2 1 1 4 4 4 2 Domain of Unknown Function (DUF3856) Sel1 PF08238.12 ETO20897.1 - 0.039 14.7 13.9 13 6.6 0.0 6.4 7 0 0 7 7 6 0 Sel1 repeat TPR_5 PF12688.7 ETO20897.1 - 0.041 14.1 0.1 20 5.4 0.0 4.3 3 2 3 6 6 4 0 Tetratrico peptide repeat TEX29 PF15839.5 ETO20897.1 - 0.061 13.9 2.8 5.9 7.6 0.0 4.4 4 0 0 4 4 3 0 Testis-expressed sequence 29 protein DUF5475 PF17569.2 ETO20897.1 - 0.064 13.6 1.2 3.8 7.9 0.1 3.9 2 2 1 3 3 3 0 Family of unknown function (DUF5475) PPR_2 PF13041.6 ETO20897.1 - 0.14 12.4 13.5 6.8 7.0 0.1 5.8 6 0 0 6 6 5 0 PPR repeat family SPO22 PF08631.10 ETO20897.1 - 0.89 9.0 9.2 30 4.0 0.1 4.9 5 1 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like Pkinase PF00069.25 ETO20898.1 - 2.2e-18 66.6 0.2 4e-18 65.7 0.2 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO20898.1 - 4.9e-16 58.8 0.1 4.9e-16 58.8 0.1 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase Menin PF05053.13 ETO20898.1 - 0.72 8.1 11.2 1 7.6 11.2 1.1 1 0 0 1 1 1 0 Menin Usp PF00582.26 ETO20899.1 - 4.6e-22 79.1 0.9 1.8e-15 57.7 0.1 2.3 2 0 0 2 2 2 2 Universal stress protein family PUF PF00806.19 ETO20900.1 - 0.024 14.3 2.1 0.71 9.7 1.3 2.7 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat DUF2615 PF11027.8 ETO20901.1 - 0.19 11.9 4.2 0.16 12.1 2.5 1.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) Tub_N PF16322.5 ETO20902.1 - 0.0063 16.9 14.2 0.0063 16.9 14.2 5.5 2 2 2 4 4 4 1 Tubby N-terminal SUIM_assoc PF16619.5 ETO20902.1 - 0.0064 16.5 0.0 0.0064 16.5 0.0 6.6 4 1 2 6 6 6 1 Unstructured region C-term to UIM in Ataxin3 ATP_bind_1 PF03029.17 ETO20903.1 - 9.9e-47 159.7 3.3 4.5e-38 131.4 0.9 3.5 2 1 0 2 2 2 2 Conserved hypothetical ATP binding protein TPR_1 PF00515.28 ETO20903.1 - 3.8e-11 42.3 10.0 0.0037 17.0 0.5 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO20903.1 - 3.4e-08 33.0 9.3 0.013 15.6 0.3 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO20903.1 - 1.1e-06 28.6 5.5 0.023 15.1 0.1 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO20903.1 - 1.5e-06 27.7 8.7 1.8e-05 24.3 1.2 3.9 4 0 0 4 4 4 1 TPR repeat TPR_8 PF13181.6 ETO20903.1 - 2.9e-05 23.9 9.9 0.48 10.8 0.3 5.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO20903.1 - 0.00026 21.6 0.1 0.0074 16.9 0.0 2.5 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO20903.1 - 0.00048 20.6 0.4 0.014 15.9 0.0 3.0 2 1 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO20903.1 - 0.0012 19.4 0.4 0.82 10.7 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO20903.1 - 0.0017 17.8 0.6 1 8.9 0.0 3.0 3 0 0 3 3 3 1 SHNi-TPR AAA_11 PF13086.6 ETO20903.1 - 0.0045 16.8 7.8 0.034 13.9 0.0 2.3 2 0 0 2 2 2 1 AAA domain TPR_12 PF13424.6 ETO20903.1 - 0.0074 16.6 2.2 2 8.7 0.2 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat AAA_19 PF13245.6 ETO20903.1 - 0.021 15.2 0.0 0.057 13.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain ANAPC3 PF12895.7 ETO20903.1 - 0.034 14.4 6.9 0.25 11.6 2.3 3.0 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 RNA_helicase PF00910.22 ETO20903.1 - 0.038 14.4 0.1 0.16 12.4 0.0 2.1 2 0 0 2 2 2 0 RNA helicase AAA PF00004.29 ETO20903.1 - 0.05 14.0 0.0 0.15 12.5 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_33 PF13671.6 ETO20903.1 - 0.061 13.5 0.2 0.28 11.3 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO20903.1 - 0.1 12.8 0.0 0.37 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain CbiA PF01656.23 ETO20903.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.6 1 1 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_16 PF13191.6 ETO20903.1 - 0.15 12.4 0.0 0.6 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain DUF87 PF01935.17 ETO20903.1 - 0.22 11.6 2.6 1.5 8.8 0.0 2.6 2 0 0 2 2 2 0 Helicase HerA, central domain TPR_7 PF13176.6 ETO20903.1 - 0.25 11.5 1.4 1.8 8.7 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat AAA_17 PF13207.6 ETO20903.1 - 0.36 11.3 2.5 0.39 11.1 0.1 2.2 2 0 0 2 2 2 0 AAA domain Hydin_ADK PF17213.3 ETO20903.1 - 0.62 10.3 5.1 4.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain TPR_6 PF13174.6 ETO20903.1 - 3.4 8.5 4.7 9.4 7.1 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Alkyl_sulf_dimr PF14863.6 ETO20903.1 - 7.4 7.0 7.8 5.9 7.3 0.3 2.4 2 0 0 2 2 2 0 Alkyl sulfatase dimerisation Ank_4 PF13637.6 ETO20905.1 - 6.8e-19 68.0 0.4 1.2e-12 48.1 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO20905.1 - 1.6e-14 52.5 1.0 5e-06 26.4 0.1 2.8 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ETO20905.1 - 1.8e-14 54.1 0.3 7.7e-14 52.0 0.3 1.9 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO20905.1 - 2.8e-12 46.5 3.1 2.5e-05 24.5 0.3 2.4 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO20905.1 - 9.9e-11 41.7 1.6 1.5e-07 31.5 0.8 2.8 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Guanylate_kin PF00625.21 ETO20906.1 - 8.9e-10 38.5 0.3 8.5e-07 28.8 0.1 2.1 2 0 0 2 2 2 2 Guanylate kinase RsgA_GTPase PF03193.16 ETO20906.1 - 3.2e-05 23.9 0.1 0.00083 19.3 0.0 2.1 2 0 0 2 2 2 1 RsgA GTPase AAA_18 PF13238.6 ETO20906.1 - 0.0017 18.9 0.6 0.029 14.9 0.6 2.4 1 1 0 1 1 1 1 AAA domain AAA_23 PF13476.6 ETO20906.1 - 0.0056 17.2 1.2 0.0076 16.8 1.2 1.3 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO20906.1 - 0.0086 16.5 0.4 0.02 15.3 0.4 1.7 1 1 0 1 1 1 1 RNA helicase Septin PF00735.18 ETO20906.1 - 0.014 14.7 0.0 0.017 14.4 0.0 1.3 1 0 0 1 1 1 0 Septin Rad17 PF03215.15 ETO20906.1 - 0.019 14.9 0.7 0.035 14.0 0.5 1.7 1 1 0 1 1 1 0 Rad17 P-loop domain AAA_16 PF13191.6 ETO20906.1 - 0.045 14.1 0.1 0.12 12.8 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ETO20906.1 - 0.051 13.3 0.3 0.14 11.9 0.0 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO20906.1 - 0.058 13.7 0.8 0.35 11.2 0.1 2.2 2 1 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO20906.1 - 0.063 13.8 0.9 0.3 11.6 0.9 2.1 1 1 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 ETO20906.1 - 0.1 12.7 1.0 0.44 10.6 1.0 1.9 1 1 0 1 1 1 0 50S ribosome-binding GTPase AAA_33 PF13671.6 ETO20906.1 - 0.19 11.9 0.6 0.69 10.1 0.6 1.9 1 1 0 1 1 1 0 AAA domain DUF5090 PF17009.5 ETO20908.1 - 0.033 14.2 3.8 0.057 13.4 3.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) CoA_binding_3 PF13727.6 ETO20908.1 - 0.076 13.0 2.0 0.14 12.2 2.0 1.3 1 0 0 1 1 1 0 CoA-binding domain AAA PF00004.29 ETO20910.1 - 2.6e-18 66.7 0.0 3.8e-18 66.2 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ETO20910.1 - 6.7e-09 35.6 0.4 1.7e-08 34.3 0.3 1.8 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ETO20910.1 - 1.1e-07 31.5 0.0 2.2e-07 30.6 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain DUF4449 PF14613.6 ETO20911.1 - 3.3 7.8 8.8 0.11 12.7 1.0 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF4449) Elf4 PF07011.11 ETO20913.1 - 0.016 15.1 0.4 2.3 8.2 0.1 2.8 2 1 0 2 2 2 0 Early Flowering 4 domain Histidinol_dh PF00815.20 ETO20913.1 - 0.09 11.8 0.7 0.12 11.4 0.7 1.2 1 0 0 1 1 1 0 Histidinol dehydrogenase HTH_51 PF18558.1 ETO20913.1 - 0.096 12.6 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain DUF1664 PF07889.12 ETO20913.1 - 0.13 12.3 3.5 0.93 9.5 1.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) YkuI_C PF10388.9 ETO20913.1 - 0.22 11.3 2.7 1.3 8.8 0.0 2.4 2 1 0 2 2 2 0 EAL-domain associated signalling protein domain DUF202 PF02656.15 ETO20914.1 - 2.1e-09 37.7 1.3 4.3e-09 36.7 1.3 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF202) VTC PF09359.10 ETO20914.1 - 0.00011 21.7 0.0 0.00016 21.2 0.0 1.3 1 0 0 1 1 1 1 VTC domain Ribosomal_S19e PF01090.19 ETO20914.1 - 0.06 13.0 0.0 0.1 12.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S19e TMEM135_C_rich PF15982.5 ETO20915.1 - 0.0076 16.9 0.1 0.011 16.3 0.1 1.2 1 0 0 1 1 1 1 N-terminal cysteine-rich region of Transmembrane protein 135 zf-MYST PF17772.1 ETO20915.1 - 1.1 9.0 4.0 2.4 7.8 3.9 1.6 1 1 0 1 1 1 0 MYST family zinc finger domain SARAF PF06682.12 ETO20915.1 - 3.3 7.3 19.1 0.097 12.3 0.1 2.2 1 1 1 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Otopetrin PF03189.13 ETO20915.1 - 6.7 5.4 9.4 0.33 9.7 1.9 1.9 1 1 0 2 2 2 0 Otopetrin Utp12 PF04003.12 ETO20916.1 - 4.6e-13 49.4 0.7 6.6e-13 48.9 0.7 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family Caldesmon PF02029.15 ETO20916.1 - 0.00075 18.4 21.0 0.00086 18.2 21.0 1.1 1 0 0 1 1 1 1 Caldesmon CDC45 PF02724.14 ETO20916.1 - 0.0053 15.1 9.3 0.0055 15.1 9.3 1.2 1 0 0 1 1 1 1 CDC45-like protein Zip PF02535.22 ETO20916.1 - 0.028 13.7 3.8 0.029 13.6 3.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 ETO20916.1 - 0.24 9.4 21.6 0.41 8.7 21.6 1.4 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO20916.1 - 0.27 10.0 12.5 0.36 9.5 12.5 1.3 1 0 0 1 1 1 0 Presenilin DDRGK PF09756.9 ETO20916.1 - 0.41 10.2 34.0 0.033 13.8 28.4 1.9 2 0 0 2 2 2 0 DDRGK domain ThiS PF02597.20 ETO20916.1 - 0.48 11.1 4.8 2.1 9.1 0.7 2.8 1 1 2 3 3 2 0 ThiS family BUD22 PF09073.10 ETO20916.1 - 0.49 9.7 23.7 0.01 15.2 17.1 1.6 2 0 0 2 2 2 0 BUD22 PPL5 PF18168.1 ETO20916.1 - 0.58 9.4 13.4 0.97 8.7 13.4 1.4 1 0 0 1 1 1 0 Prim-pol family 5 FYDLN_acid PF09538.10 ETO20916.1 - 0.63 10.7 16.3 0.3 11.8 13.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF4637 PF15470.6 ETO20916.1 - 0.65 9.7 19.5 0.25 11.1 16.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DDHD PF02862.17 ETO20916.1 - 0.81 9.8 11.9 0.56 10.3 10.6 1.4 1 1 0 1 1 1 0 DDHD domain Eapp_C PF10238.9 ETO20916.1 - 0.86 9.7 11.7 0.14 12.3 7.7 1.9 2 0 0 2 2 2 0 E2F-associated phosphoprotein Trypan_PARP PF05887.11 ETO20916.1 - 1.3 9.0 21.9 1.9 8.4 21.9 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FAM60A PF15396.6 ETO20916.1 - 1.4 8.9 14.0 0.17 11.9 9.8 1.7 2 0 0 2 2 2 0 Protein Family FAM60A SLC12 PF03522.15 ETO20916.1 - 1.6 7.7 14.1 0.3 10.1 10.0 1.9 2 0 0 2 2 2 0 Solute carrier family 12 DUF913 PF06025.12 ETO20916.1 - 1.9 7.4 10.3 2.9 6.8 10.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) OATP PF03137.20 ETO20916.1 - 2.2 6.4 4.9 2.9 6.1 4.9 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family GET2 PF08690.10 ETO20916.1 - 2.4 7.8 11.3 0.31 10.7 7.4 1.6 2 0 0 2 2 2 0 GET complex subunit GET2 SpoIIIAH PF12685.7 ETO20916.1 - 3.1 7.6 22.4 0.36 10.6 18.3 1.5 2 0 0 2 2 2 0 SpoIIIAH-like protein Pox_Ag35 PF03286.14 ETO20916.1 - 4.1 7.1 26.4 10 5.9 26.4 1.6 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2828 PF11443.8 ETO20916.1 - 5.7 4.9 19.0 9.3 4.2 19.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF2828) FAM178 PF14816.6 ETO20916.1 - 5.7 5.8 12.8 12 4.7 12.8 1.7 1 1 0 1 1 1 0 Family of unknown function, FAM178 Ureide_permease PF07168.11 ETO20916.1 - 5.8 5.6 12.3 11 4.7 12.3 1.4 1 0 0 1 1 1 0 Ureide permease Nucleoside_tran PF01733.18 ETO20916.1 - 9.2 5.5 5.9 15 4.8 5.9 1.4 1 0 0 1 1 1 0 Nucleoside transporter CPSF100_C PF13299.6 ETO20916.1 - 9.2 6.4 16.9 8.4 6.6 14.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Guanylate_cyc PF00211.20 ETO20917.1 - 7.3e-15 55.0 0.2 1.3e-08 34.7 0.0 3.7 2 2 1 3 3 3 2 Adenylate and Guanylate cyclase catalytic domain Sigma70_ner PF04546.13 ETO20918.1 - 0.59 10.0 7.8 1.1 9.1 7.8 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.14 ETO20918.1 - 0.89 7.8 9.2 1 7.6 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein TFB6 PF17110.5 ETO20918.1 - 1.1 9.0 4.6 2.2 8.0 4.6 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CENP-B_dimeris PF09026.10 ETO20918.1 - 1.7 9.1 12.7 3.3 8.1 12.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO20918.1 - 1.8 6.6 9.8 2.4 6.2 9.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi Merozoite_SPAM PF07133.11 ETO20918.1 - 3.1 7.8 20.3 1.4 8.8 17.8 1.7 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) RRN3 PF05327.11 ETO20918.1 - 7.1 5.0 7.3 9 4.7 7.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Jacalin PF01419.17 ETO20920.1 - 3.6e-06 26.9 0.0 0.00027 20.9 0.0 2.4 1 1 0 2 2 2 2 Jacalin-like lectin domain Menin PF05053.13 ETO20920.1 - 0.62 8.4 3.7 0.8 8.0 3.7 1.1 1 0 0 1 1 1 0 Menin MMgT PF10270.9 ETO20921.1 - 0.0055 17.0 3.2 0.0055 17.0 3.2 1.7 1 1 1 2 2 2 1 Membrane magnesium transporter DUF5362 PF17319.2 ETO20921.1 - 0.14 12.0 1.5 0.25 11.2 1.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5362) RSN1_TM PF13967.6 ETO20921.1 - 0.19 11.5 2.7 0.34 10.6 2.7 1.4 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport Orf78 PF06024.12 ETO20921.1 - 1.6 9.0 8.6 7.9 6.8 1.9 2.3 1 1 1 2 2 2 0 Orf78 (ac78) G-alpha PF00503.20 ETO20922.1 - 2e-34 119.3 3.9 2.6e-34 119.0 3.9 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO20922.1 - 0.00031 20.2 0.4 0.00067 19.2 0.4 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF1866 PF08952.11 ETO20922.1 - 0.12 12.2 0.7 2.2 8.1 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF1866) RabGAP-TBC PF00566.18 ETO20923.1 - 8.3e-26 91.0 11.8 1.2e-13 51.3 5.0 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain SR-25 PF10500.9 ETO20923.1 - 0.016 14.8 4.8 0.022 14.4 4.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 ETO20923.1 - 0.45 10.8 17.3 11 6.3 16.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF755) DAGAT PF03982.13 ETO20924.1 - 7.1e-56 189.3 0.2 1.7e-55 188.0 0.1 1.6 1 1 1 2 2 2 1 Diacylglycerol acyltransferase PGAP1 PF07819.13 ETO20926.1 - 1.1e-33 116.8 1.1 1.1e-33 116.8 1.1 1.9 2 0 0 2 2 2 1 PGAP1-like protein DUF676 PF05057.14 ETO20926.1 - 2.8e-06 27.0 0.6 6.1e-06 25.9 0.6 1.6 1 0 0 1 1 1 1 Putative serine esterase (DUF676) DUF900 PF05990.12 ETO20926.1 - 1.5e-05 24.6 0.0 2.7e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase of unknown function (DUF900) Hydrolase_4 PF12146.8 ETO20926.1 - 0.00083 18.7 0.0 0.0016 17.8 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO20926.1 - 0.052 14.1 0.0 0.081 13.5 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family DUF1749 PF08538.10 ETO20926.1 - 0.062 12.4 0.0 0.14 11.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1749) RIO1 PF01163.22 ETO20927.1 - 0.016 14.8 0.2 0.045 13.4 0.2 1.8 1 0 0 1 1 1 0 RIO1 family Hexokinase_1 PF00349.21 ETO20927.1 - 0.056 13.3 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 Hexokinase ADP_ribosyl_GH PF03747.14 ETO20928.1 - 7.4e-14 52.2 0.2 1.7e-13 51.0 0.0 1.6 2 0 0 2 2 2 1 ADP-ribosylglycohydrolase DUF3197 PF11432.8 ETO20928.1 - 0.0081 16.0 0.0 0.1 12.5 0.0 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF3197) SAM_1 PF00536.30 ETO20928.1 - 0.058 13.8 0.1 0.7 10.4 0.0 2.6 1 1 1 2 2 2 0 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO20929.1 - 2.5e-52 173.7 10.1 1e-09 38.8 0.0 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20929.1 - 1.4e-17 63.8 0.0 0.0063 16.8 0.0 5.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20929.1 - 4.5e-16 58.7 0.1 6.7e-05 22.0 0.0 5.4 1 1 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO20929.1 - 1.9e-10 40.9 0.3 0.0088 15.9 0.0 3.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO20929.1 - 1.3e-06 28.1 4.8 0.78 9.8 0.0 5.8 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO20929.1 - 2.8e-05 23.6 3.1 0.13 11.5 0.2 3.2 2 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO20929.1 - 0.00075 18.3 0.1 5.5 5.5 0.1 3.6 3 1 1 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO20929.1 - 0.056 12.0 0.0 0.5 8.9 0.0 2.2 1 1 0 2 2 2 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO20929.1 - 0.23 11.2 0.8 1.1e+02 2.6 0.1 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DNA_pol3_delta PF06144.13 ETO20929.1 - 1.5 8.6 6.5 2.8 7.7 0.5 2.3 2 0 0 2 2 2 0 DNA polymerase III, delta subunit WD40 PF00400.32 ETO20930.1 - 1.9e-21 76.0 14.2 1.1e-06 29.3 0.2 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO20930.1 - 5.2e-06 25.4 0.7 0.54 8.8 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO20930.1 - 7.3e-06 26.2 0.1 0.072 13.4 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO20930.1 - 0.0075 15.6 0.8 0.13 11.5 0.3 2.1 1 1 0 2 2 2 1 WD40-like domain DUF1541 PF07563.11 ETO20930.1 - 0.11 12.3 0.0 2.1 8.3 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) DUF4221 PF13970.6 ETO20930.1 - 0.56 9.7 3.6 3.5 7.1 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Kelch_6 PF13964.6 ETO20931.1 - 2.3e-07 30.9 0.3 0.042 14.1 0.0 4.3 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO20931.1 - 3.8e-06 26.4 0.5 0.17 11.5 0.1 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO20931.1 - 0.0048 16.8 0.3 8.9 6.5 0.0 3.9 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO20931.1 - 0.11 12.5 2.9 0.75 9.9 0.5 3.4 4 0 0 4 4 4 0 Kelch motif DUF2684 PF10885.8 ETO20931.1 - 0.14 12.2 1.1 0.49 10.5 1.1 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2684) DUF948 PF06103.11 ETO20933.1 - 0.0063 16.7 6.5 0.042 14.1 6.1 2.4 1 1 1 2 2 2 2 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 ETO20933.1 - 0.031 14.3 9.6 0.43 10.6 1.5 2.5 1 1 1 2 2 2 0 Laminin Domain II HAUS6_N PF14661.6 ETO20933.1 - 2.2 7.8 14.1 42 3.6 14.1 2.0 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DOCK_N PF16172.5 ETO20934.1 - 0.026 13.5 0.1 0.036 13.0 0.1 1.2 1 0 0 1 1 1 0 DOCK N-terminus zf-Sec23_Sec24 PF04810.15 ETO20935.1 - 0.00013 21.9 0.6 0.00055 19.9 0.6 2.0 1 1 0 1 1 1 1 Sec23/Sec24 zinc finger Menin PF05053.13 ETO20935.1 - 0.049 12.0 8.2 0.06 11.7 8.2 1.2 1 0 0 1 1 1 0 Menin VWA_CoxE PF05762.14 ETO20935.1 - 0.16 11.4 0.0 0.25 10.7 0.0 1.2 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein Ras PF00071.22 ETO20937.1 - 3e-15 56.2 0.0 5.4e-15 55.4 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO20937.1 - 3.1e-10 40.3 0.0 7.1e-10 39.1 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 ETO20937.1 - 0.0026 17.7 0.0 0.005 16.8 0.0 1.5 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 ETO20937.1 - 0.0058 16.6 0.7 0.011 15.6 0.1 1.8 2 0 0 2 2 2 1 ATPase domain predominantly from Archaea DUF1394 PF07159.12 ETO20937.1 - 0.024 13.9 0.4 0.76 9.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1394) cobW PF02492.19 ETO20937.1 - 0.03 13.9 0.2 0.087 12.4 0.0 1.8 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain DnaB_2 PF07261.11 ETO20937.1 - 0.095 12.5 0.9 0.71 9.7 0.3 2.3 2 0 0 2 2 2 0 Replication initiation and membrane attachment DNA_primase_lrg PF04104.14 ETO20938.1 - 5.6e-46 157.1 3.0 5.6e-46 157.1 3.0 1.6 2 1 0 2 2 2 1 Eukaryotic and archaeal DNA primase, large subunit DUF4834 PF16118.5 ETO20938.1 - 2.9 8.9 6.8 0.4 11.7 1.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF2606 PF10794.9 ETO20939.1 - 0.055 13.2 0.1 0.1 12.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2606) TLP-20 PF06088.11 ETO20939.1 - 1.2 9.0 5.5 0.36 10.7 2.4 1.7 1 1 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Vps39_1 PF10366.9 ETO20940.1 - 1.2e-08 35.1 6.5 1.1e-06 28.9 6.5 2.5 1 1 0 1 1 1 1 Vacuolar sorting protein 39 domain 1 Clathrin PF00637.20 ETO20940.1 - 0.0017 18.2 1.3 0.0096 15.8 1.3 2.0 1 1 0 1 1 1 1 Region in Clathrin and VPS DRY_EERY PF09750.9 ETO20940.1 - 0.023 15.0 0.9 0.035 14.4 0.9 1.3 1 0 0 1 1 1 0 Alternative splicing regulator AGA2 PF17366.2 ETO20940.1 - 0.18 11.5 0.0 0.34 10.6 0.0 1.4 1 0 0 1 1 1 0 A-agglutinin-binding subunit Aga2 CNH PF00780.22 ETO20941.1 - 2.8e-08 33.7 0.0 5.2e-08 32.8 0.0 1.4 1 0 0 1 1 1 1 CNH domain TPR_3 PF07720.12 ETO20941.1 - 0.57 10.2 3.4 1.4 9.0 3.4 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Baculo_11_kDa PF06143.11 ETO20942.1 - 0.074 12.6 0.0 0.22 11.1 0.0 1.8 1 0 0 1 1 1 0 Baculovirus 11 kDa family Orf78 PF06024.12 ETO20942.1 - 0.32 11.3 0.0 0.32 11.3 0.0 4.2 3 1 0 3 3 3 0 Orf78 (ac78) O-antigen_lig PF13425.6 ETO20942.1 - 6.9 5.3 6.0 24 3.6 0.1 2.4 2 0 0 2 2 2 0 O-antigen ligase like membrane protein EOS1 PF12326.8 ETO20942.1 - 7.1 6.5 8.4 48 3.8 0.0 3.1 3 1 0 3 3 3 0 N-glycosylation protein Peptidase_S10 PF00450.22 ETO20943.1 - 5.8e-42 144.6 1.5 6.8e-42 144.3 1.5 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase RRM_1 PF00076.22 ETO20944.1 - 4.5e-06 26.4 0.0 0.086 12.7 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Spt5_N PF11942.8 ETO20944.1 - 9.7 7.2 14.8 1.6 9.8 8.9 2.8 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal Beta-Casp PF10996.8 ETO20945.1 - 3.7e-28 98.0 0.0 8.4e-28 96.9 0.0 1.6 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B_6 PF16661.5 ETO20945.1 - 8.5e-16 57.9 0.3 2.1e-15 56.7 0.2 1.7 2 0 0 2 2 2 1 Metallo-beta-lactamase superfamily domain Lactamase_B PF00753.27 ETO20945.1 - 1.1e-12 48.3 0.0 4.1e-12 46.5 0.0 1.8 1 1 0 1 1 1 1 Metallo-beta-lactamase superfamily CPSF73-100_C PF11718.8 ETO20945.1 - 1.1e-08 34.9 0.1 3.4e-08 33.3 0.0 1.8 2 0 0 2 2 2 1 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term RMMBL PF07521.12 ETO20945.1 - 6e-07 29.3 0.0 1.4e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 Zn-dependent metallo-hydrolase RNA specificity domain Lactamase_B_2 PF12706.7 ETO20945.1 - 0.0016 18.0 0.0 0.0038 16.8 0.0 1.6 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Lactamase_B_3 PF13483.6 ETO20945.1 - 0.0049 16.8 0.0 0.017 15.0 0.0 1.9 1 1 0 1 1 1 1 Beta-lactamase superfamily domain FAD_binding_1 PF00667.20 ETO20946.1 - 2.4e-22 79.6 0.0 2.1e-19 70.0 0.0 2.4 2 0 0 2 2 2 2 FAD binding domain NAD_binding_1 PF00175.21 ETO20946.1 - 3e-12 47.1 0.0 5.2e-12 46.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DndE PF08870.11 ETO20947.1 - 0.12 12.7 0.1 0.31 11.3 0.1 1.7 1 1 0 1 1 1 0 DNA sulphur modification protein DndE TonB_N PF16031.5 ETO20948.1 - 0.62 10.6 12.9 0.071 13.6 8.3 1.7 2 0 0 2 2 2 0 TonB polyproline region WD40 PF00400.32 ETO20949.1 - 9.4e-39 130.7 27.2 1e-06 29.3 1.5 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO20949.1 - 8.6e-11 41.2 10.5 0.0092 14.7 0.1 5.5 3 3 2 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO20949.1 - 1.2e-10 41.5 4.8 0.15 12.4 0.0 5.9 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO20949.1 - 9.3e-05 22.4 6.9 0.79 9.8 0.0 4.8 3 2 2 5 5 5 2 Ciliary BBSome complex subunit 2, middle region Glyco_hydro_49 PF03718.13 ETO20949.1 - 3.1 7.8 11.5 2.8 8.0 0.4 3.9 3 1 1 4 4 4 0 Glycosyl hydrolase family 49 His_Phos_1 PF00300.22 ETO20950.1 - 1.4e-08 34.7 0.6 2e-07 30.9 0.0 2.6 3 0 0 3 3 3 1 Histidine phosphatase superfamily (branch 1) FYVE PF01363.21 ETO20950.1 - 0.00087 19.4 0.3 0.00087 19.4 0.3 2.8 2 1 1 3 3 3 1 FYVE zinc finger zf-C3HC4_2 PF13923.6 ETO20950.1 - 0.006 16.4 5.8 0.006 16.4 5.8 2.7 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO20950.1 - 0.051 13.9 12.7 0.15 12.4 5.4 2.8 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 ETO20950.1 - 0.63 10.1 9.3 0.17 11.9 3.2 2.8 2 0 0 2 2 2 0 RING-type zinc-finger Mak16 PF04874.14 ETO20950.1 - 0.74 10.5 7.9 7.4 7.2 0.3 3.0 2 1 1 3 3 3 0 Mak16 protein C-terminal region zf-C3HC4 PF00097.25 ETO20950.1 - 0.94 9.4 15.4 0.034 14.0 4.8 3.0 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO20950.1 - 1.8 8.5 16.4 0.41 10.5 4.5 2.7 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETO20950.1 - 5 6.8 12.0 1.5 8.5 0.9 2.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type NIF PF03031.18 ETO20951.1 - 3.7e-13 49.5 0.5 7.2e-13 48.6 0.5 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Acid_PPase PF12689.7 ETO20951.1 - 0.0011 18.9 0.2 0.0021 18.0 0.2 1.5 1 0 0 1 1 1 1 Acid Phosphatase Ribosom_S30AE_C PF16321.5 ETO20951.1 - 0.15 11.8 0.7 0.35 10.6 0.2 1.9 2 0 0 2 2 2 0 Sigma 54 modulation/S30EA ribosomal protein C terminus Tmemb_161AB PF10268.9 ETO20952.1 - 0.25 9.9 6.1 0.18 10.4 4.8 1.4 2 0 0 2 2 2 0 Predicted transmembrane protein 161AB PVL_ORF50 PF07768.11 ETO20952.1 - 1.3 9.3 9.9 1.1 9.6 8.0 1.8 2 0 0 2 2 2 0 PVL ORF-50-like family DAGK_acc PF00609.19 ETO20953.1 - 2.5e-17 63.7 0.0 8.4e-17 62.0 0.0 1.9 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ETO20953.1 - 0.0066 16.1 0.4 0.035 13.7 0.0 2.3 2 0 0 2 2 2 1 Diacylglycerol kinase catalytic domain She9_MDM33 PF05546.11 ETO20953.1 - 0.02 14.7 1.4 0.02 14.7 1.4 2.6 3 0 0 3 3 3 0 She9 / Mdm33 family U3_snoRNA_assoc PF08297.11 ETO20953.1 - 0.12 13.1 12.4 0.88 10.3 2.5 3.1 3 0 0 3 3 3 0 U3 snoRNA associated Vps16_N PF04841.13 ETO20954.1 - 8.4e-18 64.3 0.0 4.4e-16 58.6 0.0 2.0 1 1 0 1 1 1 1 Vps16, N-terminal region Peptidase_S10 PF00450.22 ETO20955.1 - 3.7e-38 132.0 1.0 1.1e-23 84.3 0.1 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase E1-E2_ATPase PF00122.20 ETO20956.1 - 3.8 7.0 6.6 6.4 6.3 6.6 1.3 1 0 0 1 1 1 0 E1-E2 ATPase WD40 PF00400.32 ETO20957.1 - 9.7e-24 83.2 2.4 0.00042 21.1 0.0 6.3 6 1 0 6 6 6 5 WD domain, G-beta repeat Nop14 PF04147.12 ETO20957.1 - 0.33 9.1 29.7 0.49 8.5 29.7 1.3 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO20957.1 - 2.5 6.8 9.2 4.1 6.1 9.2 1.4 1 0 0 1 1 1 0 Presenilin HMMR_N PF15905.5 ETO20958.1 - 1.3 8.4 47.7 0.87 9.0 26.7 2.4 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Baculo_PEP_C PF04513.12 ETO20958.1 - 2 8.5 19.8 3.5 7.7 9.7 3.4 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Patched PF02460.18 ETO20958.1 - 2 6.4 7.2 2.5 6.0 7.2 1.3 1 0 0 1 1 1 0 Patched family C2 PF00168.30 ETO20959.1 - 3.4e-14 53.0 0.2 9.3e-14 51.6 0.2 1.8 1 0 0 1 1 1 1 C2 domain TBPIP PF07106.13 ETO20960.1 - 6.5e-10 38.8 0.1 1.8e-09 37.4 0.1 1.7 1 0 0 1 1 1 1 TBPIP/Hop2 winged helix domain Toxin_17 PF08086.11 ETO20960.1 - 0.025 14.8 0.8 0.053 13.8 0.8 1.5 1 0 0 1 1 1 0 Ergtoxin family TMF_TATA_bd PF12325.8 ETO20960.1 - 0.67 10.2 7.3 2.2 8.5 2.5 2.6 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF4446 PF14584.6 ETO20960.1 - 0.81 9.7 3.6 1.2 9.1 2.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Spc24 PF08286.11 ETO20960.1 - 1.7 8.9 8.1 1.1e+02 3.1 8.1 2.4 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Bud13 PF09736.9 ETO20960.1 - 3.6 8.0 9.1 0.7 10.3 5.5 1.7 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Swi5 PF07061.11 ETO20960.1 - 9.3 6.4 10.5 5.3e+02 0.8 10.5 2.8 1 1 0 1 1 1 0 Swi5 ERp29 PF07749.12 ETO20961.1 - 1.2e-19 71.0 0.0 1.7e-19 70.5 0.0 1.2 1 0 0 1 1 1 1 Endoplasmic reticulum protein ERp29, C-terminal domain Sulfotransfer_4 PF17784.1 ETO20962.1 - 2.7e-39 135.2 0.2 4.2e-39 134.6 0.2 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Pex14_N PF04695.13 ETO20964.1 - 0.011 16.4 1.7 0.012 16.3 1.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Zip PF02535.22 ETO20964.1 - 0.015 14.5 0.8 0.017 14.3 0.8 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2126 PF09899.9 ETO20964.1 - 0.11 10.5 2.6 0.13 10.4 2.6 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) FAM60A PF15396.6 ETO20964.1 - 0.12 12.4 3.3 0.12 12.4 3.3 1.0 1 0 0 1 1 1 0 Protein Family FAM60A Striatin PF08232.12 ETO20964.1 - 0.28 11.8 7.7 0.32 11.6 7.7 1.1 1 0 0 1 1 1 0 Striatin family UPF0560 PF10577.9 ETO20964.1 - 0.37 9.3 6.3 0.37 9.2 6.3 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 zf-TRAF PF02176.18 ETO20966.1 - 7.2e-06 26.6 1.3 7.2e-06 26.6 1.3 3.4 2 1 2 4 4 4 1 TRAF-type zinc finger MinE PF03776.14 ETO20966.1 - 0.0048 16.9 1.0 0.013 15.5 1.0 1.7 1 0 0 1 1 1 1 Septum formation topological specificity factor MinE Pterin_bind PF00809.22 ETO20966.1 - 0.019 14.6 0.7 0.029 14.0 0.7 1.2 1 0 0 1 1 1 0 Pterin binding enzyme RNA_polI_A14 PF08203.11 ETO20966.1 - 0.069 13.9 0.2 0.25 12.1 0.2 2.0 1 0 0 1 1 1 0 Yeast RNA polymerase I subunit RPA14 NnrU PF07298.11 ETO20967.1 - 6.2e-16 58.5 0.2 8.2e-16 58.1 0.2 1.2 1 0 0 1 1 1 1 NnrU protein TMEM192 PF14802.6 ETO20969.1 - 5.8e-05 22.3 1.8 6.6e-05 22.1 1.8 1.0 1 0 0 1 1 1 1 TMEM192 family PDR_CDR PF06422.12 ETO20969.1 - 0.017 15.0 1.8 0.036 14.0 0.6 2.0 2 0 0 2 2 2 0 CDR ABC transporter PqiA PF04403.13 ETO20969.1 - 0.056 13.3 0.5 0.18 11.6 0.1 2.0 1 1 1 2 2 2 0 Paraquat-inducible protein A DUF4199 PF13858.6 ETO20969.1 - 0.077 13.4 7.2 0.11 13.0 7.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Melibiase_2 PF16499.5 ETO20970.1 - 2e-16 60.0 0.2 2.3e-16 59.8 0.2 1.2 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase PF02065.18 ETO20970.1 - 0.00029 19.9 0.0 0.00037 19.6 0.0 1.2 1 1 0 1 1 1 1 Melibiase DUF4795 PF16043.5 ETO20970.1 - 0.0066 16.1 0.7 0.0092 15.6 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) PPR_3 PF13812.6 ETO20970.1 - 0.067 13.3 4.3 0.13 12.4 0.8 2.7 2 1 1 3 3 3 0 Pentatricopeptide repeat domain T3SS_basalb_I PF17001.5 ETO20970.1 - 0.098 13.3 0.5 0.15 12.7 0.5 1.2 1 0 0 1 1 1 0 Type III secretion basal body protein I, YscI, HrpB, PscI MIG-14_Wnt-bd PF06664.12 ETO20971.1 - 0.00037 19.8 15.6 0.011 15.0 5.1 2.1 1 1 0 2 2 2 2 Wnt-binding factor required for Wnt secretion 2TM PF13239.6 ETO20971.1 - 0.00049 20.3 3.6 0.00049 20.3 3.6 2.6 1 1 2 3 3 3 1 2TM domain Sigma_reg_N PF13800.6 ETO20971.1 - 0.075 13.3 13.9 0.098 13.0 0.9 3.6 3 1 0 3 3 3 0 Sigma factor regulator N-terminal DUF2207 PF09972.9 ETO20971.1 - 0.16 10.7 0.8 0.36 9.5 0.8 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF202 PF02656.15 ETO20971.1 - 0.2 12.2 1.4 18 5.9 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF202) DUF3290 PF11694.8 ETO20971.1 - 0.42 10.6 14.8 2.8 7.9 3.1 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3290) DUF3429 PF11911.8 ETO20971.1 - 0.49 10.7 5.0 0.57 10.5 0.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF3429) DUF5367 PF17329.2 ETO20971.1 - 0.92 9.7 12.6 3.9 7.7 0.7 2.9 2 2 2 4 4 4 0 Family of unknown function (DUF5367) DUF1129 PF06570.11 ETO20971.1 - 5.4 6.4 10.4 1.5 8.2 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1129) SCO1-SenC PF02630.14 ETO20972.1 - 1.7e-38 131.5 0.0 2.3e-38 131.1 0.0 1.1 1 0 0 1 1 1 1 SCO1/SenC AhpC-TSA PF00578.21 ETO20972.1 - 0.00013 21.8 0.0 0.00018 21.4 0.0 1.4 1 1 0 1 1 1 1 AhpC/TSA family Thioredoxin_8 PF13905.6 ETO20972.1 - 0.0017 18.6 0.0 0.0039 17.5 0.0 1.6 1 0 0 1 1 1 1 Thioredoxin-like Thioredoxin_2 PF13098.6 ETO20972.1 - 0.043 14.3 0.1 0.068 13.6 0.1 1.3 1 0 0 1 1 1 0 Thioredoxin-like domain WD40 PF00400.32 ETO20973.1 - 9e-63 206.7 15.6 4e-11 43.3 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO20973.1 - 6e-23 81.0 0.3 0.00017 21.8 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO20973.1 - 2.1e-20 72.9 0.3 0.0021 17.1 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO20973.1 - 9.6e-12 45.2 0.0 0.00049 20.0 0.0 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO20973.1 - 2.7e-10 39.4 1.9 1.3e-05 23.9 0.1 3.0 1 1 3 4 4 4 4 Cytochrome D1 heme domain WD40_like PF17005.5 ETO20973.1 - 4.5e-10 39.3 1.2 0.02 14.2 0.0 4.0 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO20973.1 - 4.2e-09 35.6 0.2 0.19 10.3 0.0 5.8 1 1 6 7 7 7 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO20973.1 - 3.4e-05 23.3 1.7 6.3 6.0 0.0 5.0 1 1 4 6 6 6 2 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO20973.1 - 0.0027 16.8 0.1 0.27 10.3 0.0 2.6 2 2 0 2 2 2 1 VID27 C-terminal WD40-like domain Ret2_MD PF18528.1 ETO20973.1 - 0.0028 18.0 0.0 7.1 7.1 0.0 3.7 3 1 1 4 4 4 1 RNA editing 3' terminal uridylyl transferase 2 middle domain DUF5122 PF17164.4 ETO20973.1 - 0.0051 17.1 0.5 1.5 9.2 0.0 4.1 4 0 0 4 4 4 1 Domain of unknown function (DUF5122) beta-propeller DUF5570 PF17731.1 ETO20973.1 - 0.0058 16.7 0.9 22 5.2 0.0 4.4 1 1 4 5 5 5 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO20973.1 - 0.0071 15.1 2.0 1 8.0 0.2 3.7 1 1 1 3 3 3 1 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO20973.1 - 0.02 14.6 7.8 9.1 6.1 0.0 5.3 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETO20973.1 - 0.062 12.9 0.1 1.7 8.2 0.1 2.3 1 1 0 2 2 2 0 PQQ-like domain PD40 PF07676.12 ETO20973.1 - 0.064 13.2 16.3 11 6.1 0.1 6.2 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO20973.1 - 0.15 12.2 0.1 24 5.1 0.0 3.8 3 1 2 5 5 5 0 Strictosidine synthase Kelch_1 PF01344.25 ETO20974.1 - 3e-07 29.9 2.3 0.0021 17.6 0.6 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO20974.1 - 2.1e-06 27.8 2.9 0.025 14.9 0.2 3.5 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO20974.1 - 5.7e-05 23.3 0.2 0.0025 18.0 0.0 3.4 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO20974.1 - 0.00017 21.5 4.4 0.037 14.0 0.2 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO20974.1 - 0.0036 17.3 1.0 0.02 14.9 0.2 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO20974.1 - 0.017 15.1 8.2 0.055 13.5 0.4 3.5 3 0 0 3 3 3 0 Kelch motif Ras PF00071.22 ETO20975.1 - 1.9e-31 108.8 0.0 2.9e-31 108.2 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO20975.1 - 8.5e-18 64.7 0.0 3.7e-17 62.6 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO20975.1 - 3.2e-08 33.2 0.0 5e-08 32.6 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO20975.1 - 3.1e-06 26.9 0.1 7e-05 22.4 0.0 2.3 1 1 1 2 2 2 1 Elongation factor Tu GTP binding domain RsgA_GTPase PF03193.16 ETO20975.1 - 0.0046 16.9 0.2 2.9 7.8 0.0 2.9 3 0 0 3 3 3 2 RsgA GTPase MMR_HSR1 PF01926.23 ETO20975.1 - 0.024 14.7 0.0 0.066 13.3 0.0 1.8 2 0 0 2 2 2 0 50S ribosome-binding GTPase DAP3 PF10236.9 ETO20975.1 - 0.1 11.8 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 SRPRB PF09439.10 ETO20975.1 - 0.12 11.8 0.0 0.3 10.5 0.0 1.7 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit NACHT PF05729.12 ETO20975.1 - 0.12 12.3 0.0 0.28 11.1 0.0 1.6 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 ETO20975.1 - 0.18 12.2 0.0 0.32 11.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain SH3_1 PF00018.28 ETO20977.1 - 7.4e-10 38.3 0.3 1.2e-09 37.6 0.3 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETO20977.1 - 1.2e-06 28.2 0.5 2.3e-06 27.3 0.5 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETO20977.1 - 0.00019 21.0 0.0 0.00041 20.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain YL1 PF05764.13 ETO20977.1 - 0.013 15.6 8.6 0.017 15.3 8.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein GREB1 PF15782.5 ETO20977.1 - 0.1 9.7 12.4 0.12 9.5 12.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SH3_3 PF08239.11 ETO20977.1 - 0.11 12.8 0.4 0.22 11.8 0.4 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain PARM PF17061.5 ETO20977.1 - 1.6 8.8 23.3 2 8.5 23.3 1.0 1 0 0 1 1 1 0 PARM SOG2 PF10428.9 ETO20977.1 - 1.7 7.8 20.8 2.1 7.4 20.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF572 PF04502.13 ETO20977.1 - 3.2 7.3 17.8 4.1 6.9 17.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Endomucin PF07010.12 ETO20977.1 - 3.5 7.5 26.4 4.6 7.1 26.4 1.1 1 0 0 1 1 1 0 Endomucin UPF0492 PF15744.5 ETO20977.1 - 3.8 6.6 19.6 4.8 6.3 19.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 OATP PF03137.20 ETO20978.1 - 0.43 8.8 0.0 0.43 8.8 0.0 2.6 3 0 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family PVL_ORF50 PF07768.11 ETO20978.1 - 9.1 6.6 10.3 0.17 12.2 3.0 1.8 2 0 0 2 2 2 0 PVL ORF-50-like family G-alpha PF00503.20 ETO20979.1 - 4.8e-26 91.7 0.4 6.3e-26 91.4 0.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Rad17 PF03215.15 ETO20979.1 - 0.0012 18.8 0.4 0.0024 17.8 0.4 1.5 1 1 0 1 1 1 1 Rad17 P-loop domain TniB PF05621.11 ETO20979.1 - 0.015 14.7 0.0 0.079 12.4 0.0 1.9 2 0 0 2 2 2 0 Bacterial TniB protein AAA_15 PF13175.6 ETO20979.1 - 0.017 14.8 1.7 0.28 10.9 2.9 1.8 1 1 1 2 2 2 0 AAA ATPase domain AAA_24 PF13479.6 ETO20979.1 - 0.022 14.5 0.2 0.038 13.7 0.2 1.5 1 1 0 1 1 1 0 AAA domain ATP_bind_1 PF03029.17 ETO20979.1 - 0.036 13.9 0.0 0.17 11.6 0.0 1.9 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein Roc PF08477.13 ETO20979.1 - 0.081 13.1 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_21 PF13304.6 ETO20979.1 - 0.1 12.4 0.4 0.12 12.1 0.4 1.4 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system MMR_HSR1 PF01926.23 ETO20979.1 - 0.13 12.4 0.1 0.35 11.0 0.1 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase DAP3 PF10236.9 ETO20979.1 - 0.13 11.4 0.1 0.2 10.8 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 ETO20979.1 - 0.17 11.7 0.0 0.31 10.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 ETO20980.1 - 2.9e-29 102.3 2.4 3.3e-29 102.2 2.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit LXG PF04740.12 ETO20980.1 - 0.013 15.2 0.1 0.015 15.0 0.1 1.1 1 0 0 1 1 1 0 LXG domain of WXG superfamily IL1_propep PF02394.16 ETO20980.1 - 0.014 16.3 0.3 0.018 16.0 0.3 1.1 1 0 0 1 1 1 0 Interleukin-1 propeptide DUF2400 PF09674.10 ETO20980.1 - 0.028 14.4 0.3 0.032 14.2 0.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) A_deaminase PF00962.22 ETO20981.1 - 1.9e-102 343.0 0.3 1.7e-100 336.6 0.3 2.5 1 1 0 1 1 1 1 Adenosine/AMP deaminase Ras PF00071.22 ETO20982.1 - 3e-05 23.7 0.1 4.1e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Ras family Caveolin PF01146.17 ETO20982.1 - 0.026 14.5 0.7 0.03 14.3 0.7 1.2 1 0 0 1 1 1 0 Caveolin PGA2 PF07543.12 ETO20983.1 - 0.0077 16.2 0.1 0.011 15.7 0.1 1.2 1 0 0 1 1 1 1 Protein trafficking PGA2 DUF4389 PF14333.6 ETO20983.1 - 0.031 14.2 0.2 0.057 13.3 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4389) DUF3074 PF11274.8 ETO20983.1 - 0.05 13.6 0.1 0.061 13.3 0.1 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3074) BT1 PF03092.16 ETO20983.1 - 0.18 10.0 0.1 0.18 10.0 0.1 1.1 1 0 0 1 1 1 0 BT1 family Nodulin_late PF07127.11 ETO20983.1 - 0.22 11.9 6.6 3.8 7.9 0.2 3.0 2 2 0 2 2 2 0 Late nodulin protein peroxidase PF00141.23 ETO20984.1 - 0.07 12.8 0.1 0.23 11.1 0.0 1.8 2 0 0 2 2 2 0 Peroxidase DUF2182 PF09948.9 ETO20986.1 - 0.1 12.5 0.1 0.14 12.0 0.1 1.2 1 0 0 1 1 1 0 Predicted metal-binding integral membrane protein (DUF2182) Presenilin PF01080.17 ETO20988.1 - 0.099 11.4 5.4 0.091 11.5 5.4 1.1 1 0 0 1 1 1 0 Presenilin Raftlin PF15250.6 ETO20988.1 - 0.58 8.8 6.4 0.63 8.7 6.4 1.0 1 0 0 1 1 1 0 Raftlin RR_TM4-6 PF06459.12 ETO20988.1 - 1.8 8.3 12.3 2.2 8.1 12.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 ETO20988.1 - 2.7 7.4 7.3 3.3 7.2 7.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Ndc1_Nup PF09531.10 ETO20988.1 - 3.1 6.4 6.2 3 6.4 6.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Spore_coat_CotO PF14153.6 ETO20988.1 - 3.4 7.5 15.4 4.6 7.1 15.4 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF913 PF06025.12 ETO20988.1 - 3.7 6.4 5.9 4.3 6.2 5.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peptidase_C97 PF05903.14 ETO20990.1 - 0.11 12.4 2.4 0.22 11.3 2.4 1.6 1 1 0 1 1 1 0 PPPDE putative peptidase domain HSBP1 PF06825.12 ETO20991.1 - 0.014 15.2 0.1 0.034 14.0 0.1 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 AAA_15 PF13175.6 ETO20991.1 - 0.071 12.8 15.5 0.092 12.4 15.5 1.1 1 0 0 1 1 1 0 AAA ATPase domain CENP-H PF05837.12 ETO20991.1 - 2.2 8.7 7.8 0.4 11.1 2.9 2.1 1 1 1 2 2 2 0 Centromere protein H (CENP-H) CDC45 PF02724.14 ETO20992.1 - 0.0096 14.3 3.9 0.011 14.1 3.9 1.1 1 0 0 1 1 1 1 CDC45-like protein Yip1 PF04893.17 ETO20992.1 - 0.031 14.0 0.0 0.036 13.8 0.0 1.2 1 0 0 1 1 1 0 Yip1 domain Ilm1 PF10311.9 ETO20992.1 - 0.053 13.2 0.1 0.074 12.7 0.1 1.2 1 0 0 1 1 1 0 Increased loss of mitochondrial DNA protein 1 Coiled-coil_56 PF09813.9 ETO20992.1 - 0.054 13.5 0.9 0.47 10.5 0.0 2.2 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 56 Menin PF05053.13 ETO20992.1 - 1.7 6.9 19.9 2.7 6.2 19.9 1.3 1 0 0 1 1 1 0 Menin Neur_chan_memb PF02932.16 ETO20992.1 - 4.1 7.4 14.1 2.2 8.3 0.2 2.1 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GW PF13457.6 ETO20993.1 - 0.14 12.7 2.1 11 6.7 0.1 3.4 1 1 1 2 2 2 0 GW (Gly-Tryp) dipeptide domain DUF5582 PF17819.1 ETO20994.1 - 0.069 13.6 1.7 0.13 12.7 0.2 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5582) ubiquitin PF00240.23 ETO20996.1 - 3.7e-20 71.5 0.6 4.7e-20 71.1 0.6 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO20996.1 - 2.9e-08 33.4 0.9 4e-08 33.0 0.9 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETO20996.1 - 4.5e-07 29.8 1.3 0.00014 21.8 0.2 2.3 1 1 1 2 2 2 2 Ubiquitin-like domain DUF2407 PF10302.9 ETO20996.1 - 1.7e-05 25.3 0.6 2e-05 25.1 0.6 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO20996.1 - 0.00026 21.1 0.2 0.0004 20.5 0.2 1.4 1 1 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like YukD PF08817.10 ETO20996.1 - 0.0094 16.6 0.0 0.013 16.2 0.0 1.5 1 1 0 1 1 1 1 WXG100 protein secretion system (Wss), protein YukD Ubiquitin_2 PF14560.6 ETO20996.1 - 0.012 16.1 1.1 0.039 14.4 1.1 1.8 1 1 0 1 1 1 0 Ubiquitin-like domain DUF1870 PF08965.10 ETO20997.1 - 0.0073 16.3 0.1 0.083 12.9 0.0 2.8 3 0 0 3 3 3 1 Domain of unknown function (DUF1870) DUF3295 PF11702.8 ETO20997.1 - 0.016 14.6 0.2 0.016 14.6 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3295) SecA_PP_bind PF01043.20 ETO20998.1 - 5.6e-07 30.2 0.3 2.5e-06 28.1 0.0 2.3 2 0 0 2 2 2 1 SecA preprotein cross-linking domain Helicase_C PF00271.31 ETO20998.1 - 0.00073 19.9 1.0 0.0024 18.2 1.0 1.9 1 1 0 1 1 1 1 Helicase conserved C-terminal domain SecA_DEAD PF07517.14 ETO20999.1 - 0.18 11.0 0.2 12 5.1 0.0 2.3 1 1 1 2 2 2 0 SecA DEAD-like domain Noc2 PF03715.13 ETO20999.1 - 0.18 11.0 2.5 3.9 6.6 0.2 2.4 2 0 0 2 2 2 0 Noc2p family Proteasome PF00227.26 ETO21000.1 - 5.3e-47 159.8 0.2 7.6e-47 159.3 0.2 1.2 1 0 0 1 1 1 1 Proteasome subunit Pr_beta_C PF12465.8 ETO21000.1 - 0.52 9.7 2.3 0.75 9.2 0.0 2.3 2 0 0 2 2 2 0 Proteasome beta subunits C terminal NHase_alpha PF02979.16 ETO21002.1 - 1.5e-67 226.5 0.1 9.1e-66 220.7 0.0 2.9 2 1 1 3 3 3 1 Nitrile hydratase, alpha chain NHase_beta PF02211.15 ETO21002.1 - 2.1e-23 83.5 9.5 4e-20 72.8 2.6 3.8 1 1 1 3 3 3 2 Nitrile hydratase beta subunit DUF1392 PF07154.11 ETO21002.1 - 0.0065 16.6 0.7 1.6 8.8 0.1 2.4 2 0 0 2 2 2 2 Protein of unknown function (DUF1392) YkyA PF10368.9 ETO21002.1 - 0.055 13.1 2.5 0.64 9.7 0.2 2.4 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Zip PF02535.22 ETO21002.1 - 0.09 12.0 12.6 0.12 11.6 12.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM76 PF16046.5 ETO21002.1 - 3.4 6.9 10.4 5.5 6.3 10.4 1.3 1 0 0 1 1 1 0 FAM76 protein PBP1_TM PF14812.6 ETO21002.1 - 5.8 7.4 7.9 12 6.4 7.9 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF983 PF06170.12 ETO21004.1 - 4.7 7.7 7.1 9.7 6.7 7.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF983) ADP_ribosyl_GH PF03747.14 ETO21005.1 - 1.7e-34 119.9 0.0 8.4e-34 117.6 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylglycohydrolase FAM76 PF16046.5 ETO21006.1 - 0.083 12.2 36.7 2e+02 1.1 36.7 2.3 1 1 0 1 1 1 0 FAM76 protein zf-RING_5 PF14634.6 ETO21007.1 - 2.3e-05 24.3 5.9 6e-05 22.9 5.9 1.7 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO21007.1 - 2.5e-05 24.1 6.7 6.2e-05 22.8 6.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO21007.1 - 4.2e-05 23.8 7.4 0.0001 22.5 7.4 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_3 PF13920.6 ETO21007.1 - 0.00012 21.8 6.6 0.00012 21.8 6.6 1.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO21007.1 - 0.00018 21.6 7.2 0.00054 20.1 7.2 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETO21007.1 - 0.0065 16.3 7.1 0.0065 16.3 7.1 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_UBOX PF13445.6 ETO21007.1 - 0.015 15.3 7.0 0.015 15.3 7.0 2.3 1 1 1 2 2 2 0 RING-type zinc-finger zf-RING_10 PF16685.5 ETO21007.1 - 0.023 14.8 2.0 0.058 13.5 2.0 1.7 1 0 0 1 1 1 0 zinc RING finger of MSL2 Baculo_IE-1 PF05290.11 ETO21007.1 - 0.033 14.1 7.7 0.096 12.6 7.7 1.8 1 1 0 1 1 1 0 Baculovirus immediate-early protein (IE-0) zf-C3HC4_2 PF13923.6 ETO21007.1 - 0.18 11.7 10.1 0.45 10.4 10.1 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO21007.1 - 0.66 10.3 9.2 0.067 13.5 3.5 2.3 3 0 0 3 3 3 0 RING-H2 zinc finger domain SH3_15 PF18346.1 ETO21008.1 - 1.2e-05 25.5 0.5 0.11 12.9 0.1 2.5 2 0 0 2 2 2 2 Mind bomb SH3 repeat domain MIB_HERC2 PF06701.13 ETO21008.1 - 0.0023 18.1 0.2 1.1 9.6 0.1 2.5 2 0 0 2 2 2 2 Mib_herc2 Cul7 PF11515.8 ETO21008.1 - 0.0026 18.0 0.3 1.5 9.2 0.0 2.8 3 0 0 3 3 3 2 Mouse development and cellular proliferation protein Cullin-7 PB1 PF00564.24 ETO21008.1 - 0.012 15.6 0.6 1.6 8.7 0.1 3.0 3 0 0 3 3 3 0 PB1 domain KOW PF00467.29 ETO21008.1 - 0.12 12.4 0.5 22 5.2 0.0 3.1 3 0 0 3 3 3 0 KOW motif RbpA PF13397.6 ETO21009.1 - 0.01 16.4 1.3 0.033 14.8 1.3 1.9 1 0 0 1 1 1 0 RNA polymerase-binding protein DUF1840 PF08895.11 ETO21009.1 - 0.45 10.9 5.8 0.66 10.3 4.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) G-alpha PF00503.20 ETO21010.1 - 4.1e-86 289.3 1.8 5.3e-86 289.0 1.8 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO21010.1 - 1.7e-11 43.9 2.0 6e-08 32.3 0.5 3.1 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO21010.1 - 0.0014 18.8 0.2 2.3 8.5 0.1 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ETO21010.1 - 0.0059 16.0 4.1 0.06 12.7 0.2 2.5 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 ETO21010.1 - 0.039 13.7 0.1 0.085 12.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ETO21010.1 - 0.049 13.0 0.0 0.092 12.1 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family Mg_chelatase PF01078.21 ETO21010.1 - 0.05 13.0 0.0 0.081 12.3 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ETO21010.1 - 0.065 13.6 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Rad17 PF03215.15 ETO21010.1 - 0.08 12.9 0.0 1.3 8.9 0.0 2.2 2 0 0 2 2 2 0 Rad17 P-loop domain MMR_HSR1 PF01926.23 ETO21010.1 - 0.094 12.8 0.0 12 6.0 0.0 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF815 PF05673.13 ETO21010.1 - 0.096 11.8 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO21010.1 - 0.13 12.8 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 ABC transporter TFIIA PF03153.13 ETO21011.1 - 0.00087 19.4 55.5 0.00087 19.4 55.5 2.2 1 1 1 2 2 2 1 Transcription factor IIA, alpha/beta subunit Mpp10 PF04006.12 ETO21011.1 - 0.015 13.8 43.3 0.098 11.1 20.0 2.3 2 0 0 2 2 2 0 Mpp10 protein DUF2052 PF09747.9 ETO21011.1 - 0.044 13.9 37.3 0.56 10.3 12.1 2.9 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 ETO21011.1 - 0.063 12.7 53.7 0.082 12.3 13.0 2.4 2 0 0 2 2 2 0 SDA1 DUF913 PF06025.12 ETO21011.1 - 5.4 5.9 23.3 0.28 10.1 2.6 2.8 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) Merozoite_SPAM PF07133.11 ETO21011.1 - 9.1 6.2 62.3 0.29 11.1 18.7 2.2 2 0 0 2 2 2 0 Merozoite surface protein (SPAM) Acyl-CoA_dh_1 PF00441.24 ETO21013.1 - 5e-15 56.0 0.2 6.5e-08 32.9 0.1 2.2 2 0 0 2 2 2 2 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO21013.1 - 0.0051 17.1 0.1 0.0075 16.5 0.1 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain AP4E_app_platf PF14807.6 ETO21014.1 - 1.8e-09 37.9 0.2 6.1e-09 36.2 0.0 2.0 2 0 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform Adaptin_N PF01602.20 ETO21015.1 - 2.2e-41 142.0 0.5 2.8e-40 138.4 0.5 2.0 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_EZ PF13513.6 ETO21015.1 - 0.0095 16.4 0.0 0.027 15.0 0.0 1.8 1 0 0 1 1 1 1 HEAT-like repeat NUDIX_2 PF13869.6 ETO21016.1 - 4.4e-42 143.8 0.2 5.2e-42 143.6 0.2 1.1 1 0 0 1 1 1 1 Nucleotide hydrolase NUDIX PF00293.28 ETO21016.1 - 0.029 14.4 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 NUDIX domain Coilin_N PF15862.5 ETO21017.1 - 0.00013 21.8 0.0 0.00027 20.7 0.0 1.6 1 1 0 1 1 1 1 Coilin N-terminus Nop14 PF04147.12 ETO21017.1 - 0.24 9.6 24.0 0.36 9.0 24.0 1.2 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 ETO21017.1 - 0.7 10.3 4.8 1.2 9.6 4.8 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 SDA1 PF05285.12 ETO21017.1 - 1.1 8.6 26.1 1.7 8.0 26.1 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO21017.1 - 1.7 6.8 20.4 2.4 6.4 20.4 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ETO21017.1 - 3.7 6.0 24.5 4.8 5.7 24.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CPSF100_C PF13299.6 ETO21017.1 - 5.5 7.1 9.2 8.9 6.5 9.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Tim54 PF11711.8 ETO21017.1 - 5.7 5.6 10.5 8.4 5.1 10.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF5617 PF18493.1 ETO21018.1 - 0.072 13.2 4.1 22 5.3 0.5 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF5617) HAD_SAK_2 PF18143.1 ETO21019.1 - 2.2e-18 67.0 0.0 8e-18 65.1 0.0 1.9 1 1 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins Imm68 PF15583.6 ETO21019.1 - 0.13 12.4 0.0 0.38 10.9 0.0 1.7 1 0 0 1 1 1 0 Immunity protein 68 PA26 PF04636.13 ETO21020.1 - 1e-20 74.1 6.4 1.2e-20 73.8 6.4 1.1 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) AbiJ_NTD4 PF18863.1 ETO21020.1 - 0.28 11.7 3.2 2.3 8.7 0.0 2.4 2 1 1 3 3 3 0 AbiJ N-terminal domain 4 DUF2730 PF10805.8 ETO21021.1 - 5.9 7.1 11.0 1.2 9.3 4.7 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) Glyco_transf_92 PF01697.27 ETO21022.1 - 0.00039 20.2 0.5 0.0022 17.7 0.1 2.1 2 0 0 2 2 2 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO21022.1 - 0.00072 20.0 0.1 0.011 16.3 0.0 2.4 2 0 0 2 2 2 1 Glycosyl transferase family 2 Aph-1 PF06105.12 ETO21023.1 - 1.5e-22 80.1 17.5 1.8e-22 79.9 17.5 1.0 1 0 0 1 1 1 1 Aph-1 protein DUF4723 PF15851.5 ETO21024.1 - 0.088 13.0 0.0 0.18 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4723) DUF4059 PF13268.6 ETO21024.1 - 0.13 12.6 0.2 0.29 11.6 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4059) Ax_dynein_light PF10211.9 ETO21026.1 - 4.5e-81 271.3 16.1 5.4e-81 271.0 16.1 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain Tropomyosin_1 PF12718.7 ETO21026.1 - 0.0022 18.1 18.9 0.0043 17.2 18.9 1.4 1 0 0 1 1 1 1 Tropomyosin like ERM PF00769.19 ETO21026.1 - 0.0027 17.6 18.4 0.0052 16.6 18.4 1.4 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Jnk-SapK_ap_N PF09744.9 ETO21026.1 - 0.0079 16.4 22.7 0.064 13.5 22.7 2.2 1 1 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF737 PF05300.11 ETO21026.1 - 0.009 16.4 1.2 0.009 16.4 1.2 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF737) bZIP_1 PF00170.21 ETO21026.1 - 0.047 13.8 18.4 0.41 10.8 6.0 2.5 1 1 1 2 2 2 0 bZIP transcription factor Prominin PF05478.11 ETO21026.1 - 0.054 11.5 4.7 0.058 11.4 4.7 1.1 1 0 0 1 1 1 0 Prominin FapA PF03961.13 ETO21026.1 - 0.072 11.7 12.1 0.095 11.3 12.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF724 PF05266.14 ETO21026.1 - 0.11 12.3 14.5 0.22 11.3 14.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF724) FlaC_arch PF05377.11 ETO21026.1 - 0.13 12.7 11.0 2.1 8.8 3.0 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Uso1_p115_C PF04871.13 ETO21026.1 - 0.17 12.3 21.8 0.19 12.1 19.9 1.9 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF5320 PF17253.2 ETO21026.1 - 0.17 12.9 10.0 1.2 10.2 0.4 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) KASH_CCD PF14662.6 ETO21026.1 - 0.29 11.0 22.4 0.1 12.4 18.8 1.9 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH TSNAXIP1_N PF15739.5 ETO21026.1 - 0.33 11.3 20.1 0.7 10.3 5.6 2.7 1 1 1 2 2 2 0 Translin-associated factor X-interacting N-terminus HSP70 PF00012.20 ETO21026.1 - 0.42 8.7 7.0 0.53 8.4 7.0 1.1 1 0 0 1 1 1 0 Hsp70 protein DUF3450 PF11932.8 ETO21026.1 - 0.54 9.5 12.6 1.1 8.6 12.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) HALZ PF02183.18 ETO21026.1 - 0.58 10.4 15.0 0.19 12.0 2.9 3.0 3 0 0 3 3 2 0 Homeobox associated leucine zipper HemX PF04375.14 ETO21026.1 - 0.68 9.2 12.7 0.94 8.7 12.7 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Syntaxin-6_N PF09177.11 ETO21026.1 - 0.74 10.4 11.5 0.32 11.6 8.1 2.2 2 1 0 2 2 2 0 Syntaxin 6, N-terminal ADIP PF11559.8 ETO21026.1 - 0.96 9.5 19.0 2 8.5 19.0 1.5 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Paralemmin PF03285.15 ETO21026.1 - 1 8.9 16.8 1.6 8.2 16.8 1.3 1 0 0 1 1 1 0 Paralemmin APG6_N PF17675.1 ETO21026.1 - 1.7 9.2 24.7 1.3 9.5 22.6 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region EMP24_GP25L PF01105.24 ETO21026.1 - 1.8 8.5 9.0 0.58 10.1 5.4 2.0 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD Spc24 PF08286.11 ETO21026.1 - 2.5 8.4 18.1 0.37 11.1 8.1 2.7 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 PCRF PF03462.18 ETO21026.1 - 2.8 7.8 14.5 1.7 8.5 11.1 2.0 2 0 0 2 2 2 0 PCRF domain TMCO5 PF14992.6 ETO21026.1 - 3 7.4 19.7 2.3 7.7 18.1 1.6 1 1 0 1 1 1 0 TMCO5 family V_ATPase_I PF01496.19 ETO21026.1 - 3.7 5.3 8.3 4.4 5.1 8.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SlyX PF04102.12 ETO21026.1 - 5.5 7.7 13.3 18 6.0 1.9 2.8 1 1 1 2 2 2 0 SlyX CENP-H PF05837.12 ETO21026.1 - 6.5 7.2 15.9 4.8 7.6 14.1 1.6 2 0 0 2 2 1 0 Centromere protein H (CENP-H) Ribonuc_red_sm PF00268.21 ETO21027.1 - 1.9e-85 286.7 0.4 2.3e-85 286.5 0.4 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain Ribonuc_red_sm PF00268.21 ETO21028.1 - 1e-22 80.9 3.7 1.8e-22 80.2 3.7 1.4 1 1 0 1 1 1 1 Ribonucleotide reductase, small chain ABC2_membrane_3 PF12698.7 ETO21029.1 - 0.0023 17.1 0.0 0.0026 16.9 0.0 1.0 1 0 0 1 1 1 1 ABC-2 family transporter protein CDC45 PF02724.14 ETO21029.1 - 0.46 8.7 4.8 0.48 8.7 4.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 ETO21029.1 - 3.3 8.0 14.9 5 7.4 14.9 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated EXS PF03124.14 ETO21030.1 - 0.001 18.5 0.7 0.0013 18.2 0.7 1.0 1 0 0 1 1 1 1 EXS family DUF3292 PF11696.8 ETO21030.1 - 0.0011 17.5 0.0 0.0015 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3292) DUF2201_N PF13203.6 ETO21030.1 - 0.023 14.3 0.0 0.025 14.2 0.0 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain DUF2457 PF10446.9 ETO21030.1 - 0.44 9.6 15.6 0.56 9.3 15.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) tRNA_anti-like PF12869.7 ETO21031.1 - 0.13 11.9 0.2 0.21 11.2 0.2 1.3 1 0 0 1 1 1 0 tRNA_anti-like Chorein_N PF12624.7 ETO21032.1 - 8.8e-06 25.8 3.0 0.00029 20.9 0.2 2.4 2 1 0 2 2 2 2 N-terminal region of Chorein or VPS13 WD40 PF00400.32 ETO21033.1 - 7.2e-19 67.8 11.1 5.9e-06 26.9 0.1 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21033.1 - 8.3e-06 26.0 0.1 1.2 9.5 0.0 4.5 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DEAD PF00270.29 ETO21036.1 - 7.4e-50 169.1 0.0 2.3e-49 167.6 0.0 1.8 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO21036.1 - 2.1e-30 105.3 0.0 4.7e-29 101.0 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO21036.1 - 3.8e-05 23.7 0.0 8.4e-05 22.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Fumble PF03630.14 ETO21037.1 - 6.6e-17 61.7 0.0 9e-17 61.2 0.0 1.1 1 0 0 1 1 1 1 Fumble Fumble PF03630.14 ETO21038.1 - 2.7e-79 266.7 0.0 3.4e-79 266.4 0.0 1.0 1 0 0 1 1 1 1 Fumble zf-C2H2 PF00096.26 ETO21039.1 - 0.002 18.5 30.2 0.011 16.2 0.8 4.6 4 0 0 4 4 4 2 Zinc finger, C2H2 type DNA_pol_phi PF04931.13 ETO21039.1 - 0.87 7.6 19.4 1.7 6.7 19.4 1.4 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO21039.1 - 1.4 7.1 11.9 2.2 6.5 11.9 1.3 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.11 ETO21039.1 - 2 8.4 7.7 3.8 7.5 7.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Zf_RING PF16744.5 ETO21039.1 - 5.4 7.2 9.7 0.83 9.8 4.2 2.5 1 1 0 1 1 1 0 KIAA1045 RING finger DUF5051 PF16473.5 ETO21040.1 - 0.0019 18.2 0.1 0.013 15.5 0.1 2.4 1 1 0 1 1 1 1 3' exoribonuclease, RNase T-like DNA_pol_A_exo1 PF01612.20 ETO21040.1 - 0.014 15.2 0.3 0.35 10.6 0.1 2.4 2 0 0 2 2 2 0 3'-5' exonuclease DUF4064 PF13273.6 ETO21040.1 - 0.2 11.9 0.5 0.67 10.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4064) Pex14_N PF04695.13 ETO21040.1 - 3.1 8.4 10.8 47 4.6 0.0 3.5 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Methyltransf_2 PF00891.18 ETO21041.1 - 1.3e-30 106.3 0.0 1.9e-30 105.7 0.0 1.2 1 0 0 1 1 1 1 O-methyltransferase domain DUF5065 PF16723.5 ETO21041.1 - 0.059 13.4 0.3 0.93 9.5 0.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5065) HTH_36 PF13730.6 ETO21041.1 - 0.14 12.2 0.1 0.61 10.1 0.1 2.1 2 0 0 2 2 2 0 Helix-turn-helix domain Peptidase_S8 PF00082.22 ETO21043.1 - 9.1e-07 28.4 0.0 1.5e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Subtilase family zf-TRAF PF02176.18 ETO21044.1 - 7.6e-06 26.5 2.6 7.6e-06 26.5 2.6 2.5 3 0 0 3 3 3 1 TRAF-type zinc finger CtaG_Cox11 PF04442.14 ETO21045.1 - 1.5e-43 148.4 0.4 2.1e-43 147.9 0.4 1.2 1 0 0 1 1 1 1 Cytochrome c oxidase assembly protein CtaG/Cox11 zf-H2C2_2 PF13465.6 ETO21046.1 - 6.6e-12 45.3 23.2 5.9e-05 23.3 1.4 4.4 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2 PF00096.26 ETO21046.1 - 3e-09 36.8 28.7 0.002 18.5 0.7 4.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO21046.1 - 4.7e-09 36.3 28.4 0.0008 20.0 0.3 4.4 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETO21046.1 - 7.8e-07 28.9 16.4 6.6e-06 26.0 0.1 3.8 4 0 0 4 4 4 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ETO21046.1 - 0.00043 21.0 7.5 0.17 12.6 0.5 2.7 1 1 2 3 3 3 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 ETO21046.1 - 0.011 16.0 0.9 0.011 16.0 0.9 2.4 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_11 PF16622.5 ETO21046.1 - 0.17 11.6 0.1 0.17 11.6 0.1 3.5 4 0 0 4 4 4 0 zinc-finger C2H2-type zf-met PF12874.7 ETO21046.1 - 0.6 10.6 13.5 5 7.7 1.5 3.8 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-H2C2_5 PF13909.6 ETO21046.1 - 0.64 9.8 17.7 0.53 10.1 1.7 3.8 3 1 0 3 3 3 0 C2H2-type zinc-finger domain XPA_N PF01286.18 ETO21046.1 - 1.2 9.2 11.1 11 6.2 0.1 3.8 4 0 0 4 4 4 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 ETO21046.1 - 1.3 9.2 0.1 1.3 9.2 0.1 3.3 2 1 1 3 3 2 0 Zinc ribbon domain DUF2197 PF09963.9 ETO21046.1 - 1.4 9.3 9.0 0.69 10.2 0.3 2.8 2 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) zf-CHY PF05495.12 ETO21046.1 - 9.6 6.8 19.9 7.2e+03 -2.4 19.9 3.0 1 1 0 1 1 1 0 CHY zinc finger PDZ PF00595.24 ETO21049.1 - 0.034 14.5 0.0 0.044 14.1 0.0 1.2 1 0 0 1 1 1 0 PDZ domain SRTM1 PF15872.5 ETO21051.1 - 0.03 14.5 0.7 0.046 13.9 0.7 1.3 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Ferritin PF00210.24 ETO21053.1 - 0.13 12.2 0.6 0.25 11.3 0.6 1.4 1 0 0 1 1 1 0 Ferritin-like domain 7TM_GPCR_Srx PF10328.9 ETO21054.1 - 2 7.9 7.1 0.25 10.9 0.5 2.5 3 0 0 3 3 3 0 Serpentine type 7TM GPCR chemoreceptor Srx LON_substr_bdg PF02190.16 ETO21055.1 - 1.1e-11 45.0 2.8 1.4e-11 44.7 0.0 2.2 2 1 0 2 2 2 1 ATP-dependent protease La (LON) substrate-binding domain zf-C3HC4_4 PF15227.6 ETO21055.1 - 0.061 13.5 1.5 0.21 11.7 1.5 2.0 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING TSSC4 PF15264.6 ETO21055.1 - 0.16 12.2 4.3 0.076 13.3 1.2 2.1 2 0 0 2 2 2 0 Tumour suppressing sub-chromosomal transferable candidate 4 Brr6_like_C_C PF10104.9 ETO21055.1 - 0.18 11.6 3.3 0.13 12.0 0.7 2.2 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain OTU PF02338.19 ETO21055.1 - 1 9.8 4.6 4 8.0 0.3 2.6 2 1 0 2 2 2 0 OTU-like cysteine protease Peptidase_S10 PF00450.22 ETO21056.1 - 2.3e-29 103.1 3.3 6.4e-29 101.6 3.3 1.6 1 1 0 1 1 1 1 Serine carboxypeptidase Hydrolase_4 PF12146.8 ETO21056.1 - 0.082 12.2 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_4 PF08386.10 ETO21056.1 - 0.093 12.9 0.1 2.4 8.3 0.0 2.4 2 0 0 2 2 2 0 TAP-like protein M16C_assoc PF08367.11 ETO21057.1 - 2.2e-17 63.1 3.1 9.3e-17 61.0 3.1 1.8 1 1 0 1 1 1 1 Peptidase M16C associated Chrome_Resist PF09828.9 ETO21057.1 - 0.044 14.2 0.3 0.077 13.4 0.3 1.3 1 0 0 1 1 1 0 Chromate resistance exported protein Glyco_transf_92 PF01697.27 ETO21058.1 - 1.1e-07 31.8 0.3 1.1e-07 31.8 0.3 1.4 2 0 0 2 2 2 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO21058.1 - 0.00043 20.7 0.1 0.00072 20.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Chi-conotoxin PF16981.5 ETO21059.1 - 0.042 14.1 0.1 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 chi-Conotoxin or t superfamily DUF3911 PF13050.6 ETO21059.1 - 0.085 13.0 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3911) BSP_II PF05432.11 ETO21060.1 - 0.11 12.1 1.5 0.14 11.9 1.5 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) FATC PF02260.20 ETO21060.1 - 0.17 11.8 0.2 0.44 10.4 0.0 1.8 2 0 0 2 2 2 0 FATC domain TSGP1 PF07771.11 ETO21060.1 - 2.5 8.3 6.1 1.8 8.7 1.8 2.1 2 0 0 2 2 2 0 Tick salivary peptide group 1 ATLF PF07737.11 ETO21061.1 - 0.01 15.2 4.0 0.012 14.9 4.0 1.1 1 0 0 1 1 1 1 Anthrax toxin lethal factor, N- and C-terminal domain Dynactin_p62 PF05502.13 ETO21061.1 - 0.2 10.4 5.8 0.26 10.0 5.8 1.1 1 0 0 1 1 1 0 Dynactin p62 family Milton PF12448.8 ETO21061.1 - 0.36 10.9 5.8 0.1 12.7 0.4 2.1 1 1 1 2 2 2 0 Kinesin associated protein ANAPC15 PF15243.6 ETO21061.1 - 1 9.8 6.3 2.6 8.5 3.5 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 Vfa1 PF08432.10 ETO21061.1 - 2 8.7 11.9 2.7 8.3 11.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF1453 PF07301.11 ETO21062.1 - 0.0034 17.4 1.0 0.0078 16.2 1.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1453) DUF1325 PF07039.11 ETO21064.1 - 1.8e-05 24.8 0.2 0.00012 22.2 0.0 2.3 2 0 0 2 2 2 1 SGF29 tudor-like domain Tudor_3 PF18115.1 ETO21064.1 - 2.1e-05 24.2 0.0 4.8e-05 23.1 0.0 1.5 1 0 0 1 1 1 1 DNA repair protein Crb2 Tudor domain DUF4763 PF15960.5 ETO21065.1 - 0.0055 16.0 1.4 0.0088 15.4 1.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) Kelch_2 PF07646.15 ETO21065.1 - 0.11 12.6 0.1 3.2 7.9 0.0 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO21065.1 - 0.11 12.1 1.4 11 5.7 0.0 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO21065.1 - 0.89 9.9 3.7 3.9 7.9 0.0 3.7 4 0 0 4 4 4 0 Kelch motif DUF4355 PF14265.6 ETO21065.1 - 0.98 9.7 10.5 1.9 8.8 10.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4355) IFRD PF05004.13 ETO21066.1 - 3e-09 36.4 0.0 3e-09 36.4 0.0 3.7 3 1 2 5 5 5 1 Interferon-related developmental regulator (IFRD) Otopetrin PF03189.13 ETO21066.1 - 2.8e-05 23.1 8.1 6.6e-05 21.9 8.1 1.6 1 1 0 1 1 1 1 Otopetrin Zip PF02535.22 ETO21066.1 - 0.0056 15.9 16.7 0.13 11.5 11.3 2.3 2 0 0 2 2 2 2 ZIP Zinc transporter DUF4834 PF16118.5 ETO21066.1 - 0.0071 17.3 2.3 0.0071 17.3 2.3 3.8 3 1 0 3 3 3 1 Domain of unknown function (DUF4834) EMC3_TMCO1 PF01956.16 ETO21066.1 - 0.014 15.2 0.3 0.014 15.2 0.3 2.9 3 1 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like SID-1_RNA_chan PF13965.6 ETO21066.1 - 0.025 13.0 13.1 0.035 12.5 1.2 2.2 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 7tm_1 PF00001.21 ETO21066.1 - 0.1 11.9 1.6 0.1 11.9 0.6 1.6 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) PPP4R2 PF09184.11 ETO21066.1 - 1.3 8.5 48.4 0.17 11.4 35.0 2.5 3 0 0 3 3 3 0 PPP4R2 Zip PF02535.22 ETO21067.1 - 7.7 5.6 7.1 8 5.6 7.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO21067.1 - 9.6 4.9 9.1 12 4.5 9.1 1.1 1 0 0 1 1 1 0 Presenilin Kinesin PF00225.23 ETO21068.1 - 3.6e-23 82.0 0.1 1.7e-16 60.1 0.0 2.0 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ETO21068.1 - 6.1e-14 52.2 0.3 1.2e-07 31.8 0.0 2.1 1 1 1 2 2 2 2 Microtubule binding Paf1 PF03985.13 ETO21068.1 - 0.055 12.5 0.2 0.076 12.0 0.2 1.1 1 0 0 1 1 1 0 Paf1 RNA_pol_Rpc4 PF05132.14 ETO21069.1 - 0.043 14.2 1.4 0.052 14.0 1.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 CDC45 PF02724.14 ETO21069.1 - 0.55 8.5 4.5 0.62 8.3 4.5 1.0 1 0 0 1 1 1 0 CDC45-like protein PITH PF06201.13 ETO21071.1 - 5.6e-25 88.3 2.7 7.3e-25 88.0 2.7 1.2 1 0 0 1 1 1 1 PITH domain PBP1_TM PF14812.6 ETO21071.1 - 0.91 9.9 4.8 0.88 10.0 0.3 2.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4611 PF15387.6 ETO21071.1 - 6.9 7.0 6.6 0.77 10.0 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) RNA_pol_Rpb8 PF03870.15 ETO21072.1 - 0.021 15.0 0.2 0.028 14.6 0.2 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb8 PI3_PI4_kinase PF00454.27 ETO21073.1 - 6.1e-07 29.5 0.0 2.2e-06 27.7 0.0 1.9 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF2208 PF09973.9 ETO21073.1 - 0.057 13.0 0.0 0.089 12.4 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) Ferlin_C PF16165.5 ETO21073.1 - 0.41 10.6 2.4 12 5.8 0.0 2.4 2 0 0 2 2 2 0 Ferlin C-terminus HRDC PF00570.23 ETO21074.1 - 0.0078 16.2 0.1 0.015 15.2 0.1 1.5 1 0 0 1 1 1 1 HRDC domain CCDC50_N PF15295.6 ETO21074.1 - 0.024 14.8 2.1 0.036 14.2 2.1 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus Trp_DMAT PF11991.8 ETO21074.1 - 0.046 13.1 0.2 0.057 12.8 0.2 1.1 1 0 0 1 1 1 0 Tryptophan dimethylallyltransferase Tfb4 PF03850.14 ETO21074.1 - 0.098 12.1 0.8 0.1 12.1 0.8 1.1 1 0 0 1 1 1 0 Transcription factor Tfb4 Astro_capsid_N PF03115.14 ETO21074.1 - 0.15 10.7 4.9 0.2 10.3 4.9 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor Abi_2 PF07751.11 ETO21074.1 - 0.49 10.6 4.6 0.63 10.3 4.5 1.3 1 1 0 1 1 1 0 Abi-like protein Ndc1_Nup PF09531.10 ETO21076.1 - 0.076 11.7 13.6 0.007 15.1 8.7 1.6 1 1 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PIG-P PF08510.12 ETO21076.1 - 0.13 12.2 0.0 0.13 12.2 0.0 3.2 3 1 0 3 3 3 0 PIG-P DUF4131 PF13567.6 ETO21076.1 - 0.85 9.2 6.6 12 5.5 2.8 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) Ycf70 PF17382.2 ETO21076.1 - 2.1 8.8 4.7 10 6.6 0.8 3.0 2 1 1 3 3 3 0 Uncharacterized Ycf70-like DUF3278 PF11683.8 ETO21077.1 - 0.0009 19.3 0.7 0.0017 18.4 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3278) Neur_chan_memb PF02932.16 ETO21077.1 - 0.17 11.9 2.1 0.2 11.7 0.1 1.9 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region EF-hand_8 PF13833.6 ETO21078.1 - 1.8e-06 27.7 3.6 3.9e-06 26.6 3.6 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 ETO21078.1 - 2.2e-05 24.8 7.7 5.4e-05 23.6 6.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO21078.1 - 0.00012 21.7 6.1 0.23 11.5 2.8 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO21078.1 - 0.00087 18.7 8.4 0.25 11.0 3.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 ETO21078.1 - 0.025 14.4 3.6 0.041 13.8 1.8 2.1 1 1 1 2 2 2 0 EF hand EF-hand_5 PF13202.6 ETO21078.1 - 0.067 12.7 1.1 0.32 10.6 0.1 2.4 2 0 0 2 2 2 0 EF hand Semialdhyde_dh PF01118.24 ETO21078.1 - 0.15 12.5 0.1 0.26 11.7 0.1 1.4 1 0 0 1 1 1 0 Semialdehyde dehydrogenase, NAD binding domain SPARC_Ca_bdg PF10591.9 ETO21078.1 - 0.21 11.9 2.9 0.29 11.5 1.1 2.1 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region PARG_cat PF05028.14 ETO21079.1 - 4.6e-80 269.5 0.3 7.1e-80 268.8 0.3 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) Neisseria_TspB PF05616.13 ETO21080.1 - 0.036 12.5 10.1 0.059 11.9 10.1 1.4 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein CENP-B_dimeris PF09026.10 ETO21081.1 - 0.0017 18.7 6.3 0.0039 17.5 2.6 2.7 3 0 0 3 3 3 1 Centromere protein B dimerisation domain DUF4611 PF15387.6 ETO21081.1 - 0.67 10.2 3.9 0.99 9.7 3.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) NOA36 PF06524.12 ETO21081.1 - 4 6.7 5.9 5.5 6.2 5.9 1.2 1 0 0 1 1 1 0 NOA36 protein UBA PF00627.31 ETO21082.1 - 0.017 15.0 0.3 0.017 15.0 0.3 2.0 2 0 0 2 2 2 0 UBA/TS-N domain UBA PF00627.31 ETO21083.1 - 7.5e-11 41.7 1.8 8.3e-05 22.4 0.1 2.4 2 0 0 2 2 2 2 UBA/TS-N domain XPC-binding PF09280.11 ETO21083.1 - 9.1e-07 28.5 4.8 2.3e-06 27.2 4.5 1.9 2 0 0 2 2 2 1 XPC-binding domain VIT1 PF01988.19 ETO21083.1 - 0.061 13.2 0.2 0.093 12.6 0.2 1.5 1 1 0 1 1 1 0 VIT family CRA PF06589.11 ETO21083.1 - 2.1 8.4 9.3 3.5 7.7 9.3 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) SR-25 PF10500.9 ETO21083.1 - 4.9 6.7 28.3 0.65 9.6 12.8 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein tRNA_synt_1c_R2 PF04557.15 ETO21083.1 - 9.4 7.2 13.1 10 7.1 9.4 2.2 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 BpuSI_N PF15516.6 ETO21084.1 - 0.0022 17.9 0.9 0.0043 17.0 0.9 1.5 1 0 0 1 1 1 1 BpuSI N-terminal domain CCDC92 PF14916.6 ETO21084.1 - 0.033 14.0 0.1 0.033 14.0 0.1 4.2 4 1 0 4 4 4 0 Coiled-coil domain of unknown function MAAL_C PF07476.11 ETO21084.1 - 0.057 12.6 2.3 0.093 11.9 1.9 1.5 1 1 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus ABC1 PF03109.16 ETO21084.1 - 0.16 12.1 6.3 0.39 10.9 0.2 2.6 1 1 1 2 2 2 0 ABC1 family APG6_N PF17675.1 ETO21084.1 - 0.18 12.4 40.1 0.43 11.1 16.1 3.1 1 1 1 2 2 2 0 Apg6 coiled-coil region Atg14 PF10186.9 ETO21084.1 - 0.87 8.6 31.6 0.046 12.8 9.2 2.7 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2935 PF11155.8 ETO21084.1 - 2.4 8.5 15.7 1.3 9.4 3.6 2.5 1 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF4578 PF15147.6 ETO21084.1 - 3 8.7 8.4 0.91 10.4 1.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4578) YabA PF06156.13 ETO21084.1 - 3.7 8.2 31.3 0.15 12.7 4.4 4.0 1 1 3 4 4 4 0 Initiation control protein YabA Herpes_BLRF2 PF05812.12 ETO21084.1 - 4.2 7.5 18.0 0.2 11.8 0.9 3.5 1 1 2 3 3 3 0 Herpesvirus BLRF2 protein Tweety PF04906.13 ETO21084.1 - 5.3 5.6 14.3 0.39 9.3 8.6 1.8 1 1 0 2 2 2 0 Tweety UPF0242 PF06785.11 ETO21084.1 - 5.7 7.0 40.6 3.4 7.7 6.5 3.4 1 1 2 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus PRKG1_interact PF15898.5 ETO21084.1 - 7.5 7.5 33.9 0.35 11.8 8.5 3.5 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain IFT57 PF10498.9 ETO21085.1 - 2e-06 27.0 49.8 0.0017 17.4 16.0 3.2 1 1 2 3 3 3 2 Intra-flagellar transport protein 57 Spc7 PF08317.11 ETO21085.1 - 2.8e-06 26.5 60.8 0.0012 17.8 27.4 3.1 1 1 2 3 3 3 3 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ETO21085.1 - 3.4e-06 27.1 62.4 0.0075 16.3 13.5 4.3 1 1 2 3 3 3 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 ETO21085.1 - 1.8e-05 24.2 62.1 0.0016 17.9 23.3 2.3 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding EzrA PF06160.12 ETO21085.1 - 0.00021 19.6 52.2 0.011 13.9 12.0 2.6 1 1 2 3 3 3 2 Septation ring formation regulator, EzrA Lebercilin PF15619.6 ETO21085.1 - 0.00033 20.4 27.1 0.00033 20.4 27.1 2.8 1 1 2 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 ETO21085.1 - 0.00039 20.7 63.4 0.026 14.8 7.7 4.2 1 1 3 4 4 4 2 Autophagy protein 16 (ATG16) Filament PF00038.21 ETO21085.1 - 0.00099 18.8 58.8 0.0018 17.9 26.5 3.2 1 1 2 3 3 3 1 Intermediate filament protein Ax_dynein_light PF10211.9 ETO21085.1 - 0.0012 18.8 7.0 0.0012 18.8 7.0 4.9 1 1 4 5 5 5 1 Axonemal dynein light chain DUF2968 PF11180.8 ETO21085.1 - 0.0027 17.4 48.0 0.13 11.9 7.4 4.3 2 2 2 4 4 4 2 Protein of unknown function (DUF2968) ADIP PF11559.8 ETO21085.1 - 0.003 17.7 60.3 0.047 13.8 12.0 4.2 1 1 3 4 4 4 1 Afadin- and alpha -actinin-Binding Laminin_II PF06009.12 ETO21085.1 - 0.0039 17.2 42.2 0.78 9.8 5.1 4.5 1 1 3 4 4 4 4 Laminin Domain II ERM PF00769.19 ETO21085.1 - 0.014 15.2 56.3 0.016 15.1 41.2 2.4 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DHR10 PF18595.1 ETO21085.1 - 0.018 15.1 12.6 0.018 15.1 12.6 5.4 1 1 4 5 5 5 0 Designed helical repeat protein 10 domain LPP PF04728.13 ETO21085.1 - 0.021 15.2 29.0 0.14 12.6 0.3 7.1 2 2 2 4 4 3 0 Lipoprotein leucine-zipper TPR_MLP1_2 PF07926.12 ETO21085.1 - 0.026 14.6 60.8 0.2 11.7 7.3 4.5 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Seryl_tRNA_N PF02403.22 ETO21085.1 - 0.034 14.4 54.8 0.064 13.5 6.4 4.5 2 2 2 4 4 4 0 Seryl-tRNA synthetase N-terminal domain HMMR_N PF15905.5 ETO21085.1 - 0.041 13.4 64.6 0.17 11.3 24.7 3.2 1 1 2 3 3 3 0 Hyaluronan mediated motility receptor N-terminal AAA_13 PF13166.6 ETO21085.1 - 0.042 12.5 45.9 0.0099 14.6 23.4 2.4 1 1 1 2 2 2 0 AAA domain DUF4201 PF13870.6 ETO21085.1 - 0.064 13.0 60.5 0.16 11.7 20.7 3.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) KASH_CCD PF14662.6 ETO21085.1 - 0.067 13.0 60.0 3.2 7.5 10.4 3.2 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH DUF3584 PF12128.8 ETO21085.1 - 0.069 10.7 50.2 0.12 9.9 50.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Atg14 PF10186.9 ETO21085.1 - 0.069 12.2 52.7 0.054 12.6 16.8 3.0 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 ETO21085.1 - 0.092 13.3 63.8 0.22 12.1 16.8 3.6 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF4763 PF15960.5 ETO21085.1 - 0.12 11.7 45.3 0.25 10.6 3.5 3.8 1 1 3 4 4 4 0 Domain of unknown function (DUF4763) DUF1664 PF07889.12 ETO21085.1 - 0.12 12.4 40.6 0.094 12.8 7.2 4.6 1 1 4 5 5 4 0 Protein of unknown function (DUF1664) Taxilin PF09728.9 ETO21085.1 - 0.15 11.2 61.8 0.29 10.3 35.0 3.6 1 1 2 3 3 3 0 Myosin-like coiled-coil protein Golgin_A5 PF09787.9 ETO21085.1 - 0.16 11.4 60.4 0.076 12.5 27.0 3.1 1 1 2 3 3 3 0 Golgin subfamily A member 5 DUF4407 PF14362.6 ETO21085.1 - 0.18 11.2 37.4 1.2 8.4 18.4 3.1 1 1 3 4 4 4 0 Domain of unknown function (DUF4407) OmpH PF03938.14 ETO21085.1 - 0.2 12.0 61.2 0.15 12.4 13.7 4.2 1 1 3 4 4 4 0 Outer membrane protein (OmpH-like) MscS_porin PF12795.7 ETO21085.1 - 0.21 11.1 50.3 3.7 7.0 3.6 3.3 2 1 1 3 3 3 0 Mechanosensitive ion channel porin domain DUF4618 PF15397.6 ETO21085.1 - 0.23 10.9 53.4 0.14 11.6 15.5 3.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) YabA PF06156.13 ETO21085.1 - 0.25 12.0 51.7 2.2 9.0 7.7 5.1 1 1 3 4 4 3 0 Initiation control protein YabA Fez1 PF06818.15 ETO21085.1 - 0.28 11.6 52.2 1.6 9.2 28.8 2.7 1 1 2 3 3 3 0 Fez1 DUF812 PF05667.11 ETO21085.1 - 0.3 9.9 59.8 0.27 10.1 31.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) HAUS-augmin3 PF14932.6 ETO21085.1 - 0.3 10.6 50.8 0.083 12.5 8.4 3.5 1 1 2 3 3 3 0 HAUS augmin-like complex subunit 3 FapA PF03961.13 ETO21085.1 - 0.31 9.6 50.7 0.048 12.3 10.8 3.8 1 1 3 4 4 4 0 Flagellar Assembly Protein A MAP65_ASE1 PF03999.12 ETO21085.1 - 0.37 9.4 43.8 0.54 8.9 43.8 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) DUF4200 PF13863.6 ETO21085.1 - 0.4 11.1 63.9 1.3 9.5 4.5 4.6 2 2 1 4 4 4 0 Domain of unknown function (DUF4200) TMF_TATA_bd PF12325.8 ETO21085.1 - 0.46 10.7 57.1 2.2 8.5 10.9 4.4 1 1 3 4 4 3 0 TATA element modulatory factor 1 TATA binding DUF948 PF06103.11 ETO21085.1 - 0.48 10.7 30.1 0.1 12.8 1.5 4.8 2 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) WEMBL PF05701.11 ETO21085.1 - 0.52 8.9 51.0 2.5 6.7 16.3 2.1 1 1 1 2 2 2 0 Weak chloroplast movement under blue light FPP PF05911.11 ETO21085.1 - 0.53 8.4 51.7 5.2 5.1 51.7 2.0 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil HALZ PF02183.18 ETO21085.1 - 0.61 10.4 0.0 0.61 10.4 0.0 7.9 5 3 3 8 8 8 0 Homeobox associated leucine zipper CALCOCO1 PF07888.11 ETO21085.1 - 0.62 8.9 61.1 2.2 7.0 37.4 2.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like FUSC PF04632.12 ETO21085.1 - 0.7 8.4 12.0 1.9 6.9 3.7 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family Uso1_p115_C PF04871.13 ETO21085.1 - 0.71 10.3 56.0 3.3 8.1 12.1 4.3 1 1 3 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region DivIC PF04977.15 ETO21085.1 - 0.72 9.7 60.5 0.91 9.3 3.7 7.0 2 2 5 7 7 7 0 Septum formation initiator Laminin_I PF06008.14 ETO21085.1 - 1.4 8.6 46.6 0.4 10.3 12.5 3.3 1 1 2 3 3 3 0 Laminin Domain I HrpB7 PF09486.10 ETO21085.1 - 1.5 9.2 29.9 0.14 12.5 0.9 4.1 1 1 2 4 4 4 0 Bacterial type III secretion protein (HrpB7) BRE1 PF08647.11 ETO21085.1 - 1.7 8.8 63.4 0.45 10.6 10.6 4.2 1 1 3 4 4 4 0 BRE1 E3 ubiquitin ligase Cluap1 PF10234.9 ETO21085.1 - 1.7 7.9 48.3 1.1 8.6 15.9 2.6 1 1 1 2 2 2 0 Clusterin-associated protein-1 Fzo_mitofusin PF04799.13 ETO21085.1 - 2.4 7.7 44.2 1.1 8.8 7.8 4.2 2 1 2 4 4 4 0 fzo-like conserved region BLOC1_2 PF10046.9 ETO21085.1 - 2.7 8.3 46.4 3.9 7.8 9.7 5.2 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Occludin_ELL PF07303.13 ETO21085.1 - 2.9 8.7 44.0 2 9.2 5.6 4.6 1 1 3 4 4 4 0 Occludin homology domain Snapin_Pallidin PF14712.6 ETO21085.1 - 3.1 8.3 47.8 3.2 8.2 4.3 4.9 2 1 3 5 5 5 0 Snapin/Pallidin DUF1192 PF06698.11 ETO21085.1 - 3.4 7.8 16.2 6.9 6.8 0.6 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1192) TMPIT PF07851.13 ETO21085.1 - 3.8 6.7 48.4 0.97 8.6 6.1 3.9 1 1 3 4 4 4 0 TMPIT-like protein Leu_zip PF15294.6 ETO21085.1 - 3.9 6.9 55.2 1.5 8.3 12.7 3.4 1 1 2 3 3 3 0 Leucine zipper Tropomyosin_1 PF12718.7 ETO21085.1 - 4.1 7.6 65.9 0.063 13.4 16.4 4.3 1 1 3 4 4 4 0 Tropomyosin like Fib_alpha PF08702.10 ETO21085.1 - 4.4 7.5 47.3 0.49 10.6 8.3 4.0 1 1 3 4 4 4 0 Fibrinogen alpha/beta chain family JIP_LZII PF16471.5 ETO21085.1 - 5.8 7.2 51.8 0.38 10.9 8.8 5.8 2 2 3 5 5 5 0 JNK-interacting protein leucine zipper II CorA PF01544.18 ETO21085.1 - 7.8 5.7 36.9 0.18 11.1 9.0 3.1 1 1 2 3 3 3 0 CorA-like Mg2+ transporter protein Cep57_CLD_2 PF14197.6 ETO21085.1 - 9 6.5 52.7 0.25 11.4 13.2 5.6 2 2 1 3 3 2 0 Centrosome localisation domain of PPC89 ABC_tran_CTD PF16326.5 ETO21085.1 - 9.7 6.5 52.2 0.18 12.1 9.9 5.6 2 1 3 5 5 5 0 ABC transporter C-terminal domain Kelch_1 PF01344.25 ETO21086.1 - 4.2e-06 26.2 0.1 0.011 15.3 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO21086.1 - 0.013 15.8 0.0 1.8 8.9 0.0 2.7 2 0 0 2 2 2 0 Kelch motif RCC1_2 PF13540.6 ETO21086.1 - 0.049 13.4 0.1 3.3 7.6 0.1 2.7 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat DUF3172 PF11371.8 ETO21086.1 - 0.052 13.2 1.2 0.088 12.5 0.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3172) KduI PF04962.12 ETO21086.1 - 0.066 12.5 0.5 0.12 11.6 0.5 1.4 1 0 0 1 1 1 0 KduI/IolB family Fer4_9 PF13187.6 ETO21087.1 - 0.22 11.7 9.7 34 4.7 9.8 2.8 1 1 0 1 1 1 0 4Fe-4S dicluster domain TMEM151 PF14857.6 ETO21087.1 - 1.4 7.8 7.9 3.2 6.6 1.9 2.2 1 1 1 2 2 2 0 TMEM151 family LYRIC PF15686.5 ETO21088.1 - 2.5 7.5 28.4 4.6 6.7 28.4 1.3 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family OTU PF02338.19 ETO21090.1 - 0.00088 19.8 0.4 0.002 18.6 0.1 1.8 2 0 0 2 2 2 1 OTU-like cysteine protease Agenet PF05641.12 ETO21090.1 - 0.00099 19.5 4.8 0.1 13.1 0.6 2.6 2 0 0 2 2 2 2 Agenet domain MBT PF02820.18 ETO21090.1 - 0.0034 17.7 2.6 0.42 11.0 0.1 3.2 3 0 0 3 3 3 1 mbt repeat Tudor-knot PF11717.8 ETO21090.1 - 1.2 9.1 5.7 2.6 8.0 0.3 3.4 3 1 0 3 3 3 0 RNA binding activity-knot of a chromodomain CNDH2_C PF16858.5 ETO21092.1 - 0.0017 18.3 2.4 0.0034 17.3 2.4 1.4 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2457 PF10446.9 ETO21092.1 - 0.003 16.8 13.8 0.0044 16.2 13.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO21092.1 - 0.004 15.5 4.6 0.0055 15.0 4.6 1.2 1 0 0 1 1 1 1 Nop14-like family FAM176 PF14851.6 ETO21092.1 - 0.11 12.1 3.6 0.29 10.8 3.6 1.7 1 0 0 1 1 1 0 FAM176 family BSP_II PF05432.11 ETO21092.1 - 0.47 10.1 14.1 0.8 9.3 14.1 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4637 PF15470.6 ETO21092.1 - 0.96 9.2 7.1 1.7 8.4 7.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) RRN3 PF05327.11 ETO21092.1 - 0.96 7.9 10.1 1.5 7.3 10.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO21092.1 - 1.4 6.9 17.0 2.1 6.3 17.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sporozoite_P67 PF05642.11 ETO21092.1 - 1.8 6.6 4.8 2.5 6.1 4.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Spc7 PF08317.11 ETO21093.1 - 0.023 13.6 11.8 0.049 12.5 11.8 1.5 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETO21093.1 - 0.068 13.2 3.7 0.16 12.0 3.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DraK_HK_N PF18092.1 ETO21093.1 - 0.46 10.9 2.3 0.48 10.9 0.1 2.1 2 0 0 2 2 2 0 DraK Histidine Kinase N-terminal domain Syntaxin-6_N PF09177.11 ETO21093.1 - 1.3 9.6 5.6 5.5 7.6 0.6 2.6 1 1 1 2 2 2 0 Syntaxin 6, N-terminal WXG100 PF06013.12 ETO21093.1 - 1.7 8.9 12.2 0.08 13.2 5.6 2.2 2 0 0 2 2 2 0 Proteins of 100 residues with WXG Sulfatase_C PF14707.6 ETO21093.1 - 1.8 9.3 4.3 86 3.9 4.3 2.7 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase FlgN PF05130.12 ETO21093.1 - 3 8.3 13.7 0.28 11.7 8.9 1.7 2 0 0 2 2 2 0 FlgN protein DUF883 PF05957.13 ETO21093.1 - 3.9 8.1 5.6 2.4 8.8 2.2 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Zip PF02535.22 ETO21093.1 - 5.8 6.0 11.3 1.4 8.1 4.4 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter WD40 PF00400.32 ETO21094.1 - 8.4e-17 61.2 4.3 4.7e-05 24.1 0.1 8.3 9 0 0 9 9 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21094.1 - 4.1e-13 49.5 0.3 0.0042 17.3 0.0 5.3 4 1 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21094.1 - 0.028 13.4 0.0 0.11 11.4 0.0 1.9 1 1 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO21094.1 - 0.03 13.1 3.3 0.61 8.8 3.3 2.2 1 1 0 1 1 1 0 Nup133 N terminal like WD40 PF00400.32 ETO21095.1 - 5.7e-26 90.3 6.8 3.4e-09 37.2 0.2 6.6 7 0 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21095.1 - 9.7e-11 41.8 1.3 0.14 12.5 0.1 4.8 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain DPPIV_N PF00930.21 ETO21095.1 - 0.03 13.1 0.0 5.8 5.6 0.0 2.6 3 0 0 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO21095.1 - 0.063 13.2 3.1 6.5 6.8 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Pkinase PF00069.25 ETO21097.1 - 1.3e-18 67.3 0.0 2.7e-17 63.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21097.1 - 5.1e-13 48.9 0.0 1.8e-12 47.1 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO21097.1 - 0.0082 15.5 0.1 0.019 14.3 0.0 1.7 2 1 0 2 2 2 1 Kinase-like Rit1_C PF17184.4 ETO21098.1 - 1.7e-85 286.8 1.9 2e-85 286.6 1.2 1.5 2 0 0 2 2 2 1 Rit1 N-terminal domain Init_tRNA_PT PF04179.12 ETO21098.1 - 7.8e-11 42.3 0.1 1.4e-09 38.2 0.0 2.6 2 0 0 2 2 2 1 Rit1 DUSP-like domain DUF5523 PF17661.1 ETO21099.1 - 0.0041 16.9 8.4 0.0076 16.0 8.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5523) YflT PF11181.8 ETO21099.1 - 0.12 12.9 0.0 0.12 12.9 0.0 2.2 2 1 0 2 2 2 0 Heat induced stress protein YflT Sigma54_activ_2 PF14532.6 ETO21099.1 - 0.2 11.8 5.7 0.19 11.9 2.0 2.4 2 1 0 2 2 2 0 Sigma-54 interaction domain ANAPC15 PF15243.6 ETO21099.1 - 3.8 8.0 8.2 3.1 8.3 5.1 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 15 YfhO PF09586.10 ETO21101.1 - 0.12 10.6 1.1 0.16 10.2 1.1 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO NOA36 PF06524.12 ETO21102.1 - 2.5 7.3 9.3 2.6 7.3 9.3 1.1 1 0 0 1 1 1 0 NOA36 protein Menin PF05053.13 ETO21102.1 - 4.3 5.6 11.5 4.7 5.4 11.5 1.3 1 0 0 1 1 1 0 Menin EF-hand_7 PF13499.6 ETO21104.1 - 0.017 15.6 0.0 0.029 14.8 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 ETO21104.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain pair PA PF02225.22 ETO21105.1 - 1.3e-09 38.0 0.3 3.7e-09 36.5 0.1 1.9 2 0 0 2 2 2 1 PA domain Sigma_reg_N PF13800.6 ETO21105.1 - 0.074 13.4 0.5 4.7 7.6 0.0 2.3 2 0 0 2 2 2 0 Sigma factor regulator N-terminal ETRAMP PF09716.10 ETO21105.1 - 0.08 13.0 1.5 6.9 6.8 0.3 2.4 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) HemY_N PF07219.13 ETO21105.1 - 0.68 10.2 2.2 1.1 9.5 0.4 2.0 2 0 0 2 2 2 0 HemY protein N-terminus Nudix_hydro PF18290.1 ETO21106.1 - 2.3e-22 78.8 0.9 4.9e-22 77.7 0.3 1.8 2 0 0 2 2 2 1 Nudix hydrolase domain PHM7_cyt PF14703.6 ETO21106.1 - 0.0098 16.1 0.2 0.013 15.7 0.2 1.3 1 0 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter DUF3221 PF11518.8 ETO21106.1 - 5.5 7.4 7.5 0.49 10.8 0.5 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3221) zf-TRAF PF02176.18 ETO21108.1 - 0.00066 20.3 16.4 0.00068 20.3 3.2 3.5 3 0 0 3 3 3 1 TRAF-type zinc finger CENP-F_leu_zip PF10473.9 ETO21108.1 - 0.0043 17.1 14.4 0.0086 16.1 14.4 1.5 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Rootletin PF15035.6 ETO21108.1 - 0.023 14.7 11.9 0.039 14.0 11.9 1.3 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion TEX13 PF15186.6 ETO21108.1 - 0.027 14.2 4.5 0.052 13.2 4.5 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family DUF724 PF05266.14 ETO21108.1 - 0.042 13.7 10.4 0.098 12.5 10.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF724) zf-AD PF07776.15 ETO21108.1 - 0.044 14.0 1.2 0.15 12.3 1.2 1.9 1 0 0 1 1 1 0 Zinc-finger associated domain (zf-AD) DivIVA PF05103.13 ETO21108.1 - 0.05 13.7 8.2 0.1 12.6 8.2 1.5 1 0 0 1 1 1 0 DivIVA protein Spc7 PF08317.11 ETO21108.1 - 0.14 11.0 12.7 0.16 10.8 10.4 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein DUF948 PF06103.11 ETO21108.1 - 0.18 12.1 1.1 0.38 11.0 1.1 1.4 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Cep57_CLD_2 PF14197.6 ETO21108.1 - 0.29 11.3 11.7 0.88 9.7 11.7 1.8 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 PolC_DP2 PF03833.13 ETO21108.1 - 0.36 8.7 6.6 0.67 7.7 6.6 1.4 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 UPF0242 PF06785.11 ETO21108.1 - 0.41 10.7 20.1 0.59 10.2 18.4 2.0 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus zf-C3HC4_3 PF13920.6 ETO21108.1 - 0.91 9.4 6.7 2.1 8.3 6.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) TMF_TATA_bd PF12325.8 ETO21108.1 - 0.96 9.7 16.0 1.8 8.8 16.0 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CENP-H PF05837.12 ETO21108.1 - 2.2 8.7 12.2 3.2 8.2 10.5 1.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) FlxA PF14282.6 ETO21108.1 - 4.6 7.3 14.3 12 6.0 14.3 1.7 1 0 0 1 1 1 0 FlxA-like protein CCDC-167 PF15188.6 ETO21108.1 - 8.3 6.8 14.9 1.3 9.4 4.0 3.2 2 1 1 3 3 2 0 Coiled-coil domain-containing protein 167 PDEase_I PF00233.19 ETO21109.1 - 6.6e-77 258.4 0.1 1.4e-76 257.4 0.1 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Vfa1 PF08432.10 ETO21109.1 - 7.3 6.9 30.1 2.6 8.3 4.0 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Exo84_C PF16528.5 ETO21110.1 - 1.1e-12 48.2 1.5 1.1e-12 48.2 1.5 3.4 3 1 1 4 4 4 1 Exocyst component 84 C-terminal Vps51 PF08700.11 ETO21110.1 - 1.3e-07 31.5 3.3 3.7e-07 30.1 3.3 1.8 1 0 0 1 1 1 1 Vps51/Vps67 SSP160 PF06933.11 ETO21110.1 - 0.00011 20.7 16.9 0.00011 20.7 16.9 1.7 2 0 0 2 2 2 1 Special lobe-specific silk protein SSP160 COG2 PF06148.11 ETO21110.1 - 0.00026 21.1 1.7 0.00058 20.0 0.8 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 SPO22 PF08631.10 ETO21110.1 - 0.0011 18.5 1.4 0.0045 16.5 0.3 2.1 2 0 0 2 2 2 1 Meiosis protein SPO22/ZIP4 like ESCRT-II PF05871.12 ETO21110.1 - 0.019 15.2 1.5 0.12 12.6 1.4 2.3 2 0 0 2 2 2 0 ESCRT-II complex subunit DUF3439 PF11921.8 ETO21110.1 - 0.041 13.9 13.9 0.093 12.7 13.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) PPR PF01535.20 ETO21110.1 - 0.1 12.9 0.1 30 5.1 0.3 3.4 3 0 0 3 3 3 0 PPR repeat Mucin PF01456.17 ETO21110.1 - 0.6 10.1 29.4 0.12 12.4 22.1 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein F1F0-ATPsyn_F PF10791.9 ETO21111.1 - 0.12 12.9 0.0 1.1 9.8 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial F1-F0 ATP synthase subunit F of fungi Peptidase_M50B PF13398.6 ETO21111.1 - 0.21 11.2 0.1 0.37 10.4 0.1 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Isochorismatase PF00857.20 ETO21112.1 - 5.7e-18 65.7 0.1 3.7e-17 63.0 0.1 1.9 1 1 0 1 1 1 1 Isochorismatase family SRRM_C PF15230.6 ETO21112.1 - 0.014 16.0 0.1 0.025 15.1 0.1 1.3 1 0 0 1 1 1 0 Serine/arginine repetitive matrix protein C-terminus MCC-bdg_PDZ PF10506.9 ETO21113.1 - 0.0055 16.7 3.4 0.0093 16.0 3.4 1.4 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome NYD-SP28_assoc PF14775.6 ETO21113.1 - 0.0062 16.6 5.6 0.011 15.9 5.6 1.5 1 0 0 1 1 1 1 Sperm tail C-terminal domain SKA1 PF07160.12 ETO21113.1 - 0.016 15.1 7.7 0.017 14.9 7.7 1.0 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 BRE1 PF08647.11 ETO21113.1 - 0.021 14.9 10.5 0.028 14.5 10.5 1.1 1 0 0 1 1 1 0 BRE1 E3 ubiquitin ligase V-ATPase_H_C PF11698.8 ETO21113.1 - 0.076 13.1 3.2 0.092 12.9 3.2 1.1 1 0 0 1 1 1 0 V-ATPase subunit H CC2-LZ PF16516.5 ETO21113.1 - 0.1 13.0 12.2 0.11 12.9 4.3 2.1 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator HemX PF04375.14 ETO21113.1 - 0.13 11.5 11.3 0.15 11.3 11.3 1.0 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Dfp1_Him1_M PF08630.10 ETO21113.1 - 0.16 12.2 3.1 0.18 12.0 3.1 1.1 1 0 0 1 1 1 0 Dfp1/Him1, central region DUF4763 PF15960.5 ETO21113.1 - 0.22 10.8 10.9 0.27 10.5 10.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) TMPIT PF07851.13 ETO21113.1 - 0.39 9.9 5.6 0.42 9.8 5.6 1.0 1 0 0 1 1 1 0 TMPIT-like protein FapA PF03961.13 ETO21113.1 - 0.67 8.5 10.0 0.72 8.4 10.0 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A YabA PF06156.13 ETO21113.1 - 0.79 10.4 5.6 1.1 10.0 5.6 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Csm1_N PF18504.1 ETO21113.1 - 1.8 8.9 12.7 5 7.5 8.7 2.3 2 1 0 2 2 2 0 Csm1 N-terminal domain CdiA_C PF18451.1 ETO21113.1 - 2 8.7 8.3 1.1 9.5 1.6 2.0 1 1 1 2 2 2 0 Contact-dependent growth inhibition CdiA C-terminal domain DUF3450 PF11932.8 ETO21113.1 - 2.6 7.3 12.9 4.5 6.5 12.9 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) XLF PF09302.11 ETO21113.1 - 2.6 8.2 11.4 2.6e+02 1.7 11.4 2.2 1 1 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component DEK_C PF08766.11 ETO21114.1 - 0.00017 21.4 0.0 0.00038 20.3 0.0 1.5 1 0 0 1 1 1 1 DEK C terminal domain DUF2431 PF10354.9 ETO21115.1 - 3.9e-21 76.1 0.0 3.9e-21 76.1 0.0 1.8 2 1 0 2 2 2 1 Domain of unknown function (DUF2431) DUF2956 PF11169.8 ETO21115.1 - 0.17 12.1 5.7 0.14 12.4 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) Orf78 PF06024.12 ETO21115.1 - 0.18 12.1 1.9 0.41 11.0 1.9 1.7 1 0 0 1 1 1 0 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO21115.1 - 0.77 10.3 13.5 2.2 8.9 13.5 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3899 PF13038.6 ETO21115.1 - 2.8 8.5 6.0 3.2 8.3 0.9 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF3899) Zip PF02535.22 ETO21117.1 - 0.75 8.9 9.9 1.3 8.1 9.9 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter NicO PF03824.16 ETO21117.1 - 3.7 6.8 8.8 7 5.9 8.8 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein Presenilin PF01080.17 ETO21117.1 - 6.1 5.5 8.3 11 4.6 8.3 1.4 1 0 0 1 1 1 0 Presenilin Syntaxin-18_N PF10496.9 ETO21120.1 - 0.042 14.1 2.0 0.12 12.7 2.0 1.8 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus DUF4035 PF13227.6 ETO21120.1 - 0.17 11.7 1.4 9.7 6.0 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4035) Nup54_C PF18437.1 ETO21120.1 - 0.25 11.3 1.4 0.5 10.3 1.4 1.5 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain EF-hand_1 PF00036.32 ETO21121.1 - 5.4e-07 28.7 0.2 5.4e-07 28.7 0.2 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO21121.1 - 5.2e-06 26.0 1.5 1e-05 25.1 0.2 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ETO21121.1 - 2.6e-05 23.5 0.1 7.6e-05 22.0 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO21121.1 - 4.4e-05 23.8 0.4 4.4e-05 23.8 0.4 2.6 2 1 0 2 2 2 1 EF-hand domain pair ERM PF00769.19 ETO21121.1 - 0.013 15.3 13.6 0.013 15.3 13.6 2.5 1 1 1 2 2 2 0 Ezrin/radixin/moesin family EF-hand_8 PF13833.6 ETO21121.1 - 0.043 13.7 0.2 0.33 10.8 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain pair Caleosin PF05042.13 ETO21121.1 - 0.44 10.4 7.2 2.3 8.1 0.0 3.5 4 0 0 4 4 4 0 Caleosin related protein DUF3450 PF11932.8 ETO21121.1 - 0.94 8.7 25.9 0.32 10.3 8.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Orf78 PF06024.12 ETO21122.1 - 0.019 15.3 1.0 0.038 14.3 1.0 1.5 1 0 0 1 1 1 0 Orf78 (ac78) Vezatin PF12632.7 ETO21122.1 - 0.057 12.8 0.6 0.096 12.0 0.6 1.3 1 0 0 1 1 1 0 Mysoin-binding motif of peroxisomes RgpF PF05045.12 ETO21122.1 - 0.06 12.1 0.2 0.071 11.9 0.2 1.1 1 0 0 1 1 1 0 Rhamnan synthesis protein F Apc15p PF05841.11 ETO21122.1 - 0.32 11.8 6.4 4.1 8.2 4.3 2.5 2 0 0 2 2 2 0 Apc15p protein Menin PF05053.13 ETO21122.1 - 0.38 9.1 4.0 0.46 8.8 4.0 1.1 1 0 0 1 1 1 0 Menin NPR3 PF03666.13 ETO21123.1 - 0.0068 15.2 2.7 0.0068 15.2 2.7 2.3 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 CH PF00307.31 ETO21124.1 - 2.3e-11 43.8 0.1 1.7e-07 31.4 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain CH PF00307.31 ETO21125.1 - 2.1e-16 60.0 3.8 5.7e-09 36.1 0.1 3.8 3 1 0 3 3 3 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO21125.1 - 2.6e-06 27.1 2.4 5.8e-05 22.8 0.1 3.3 3 0 0 3 3 3 1 CAMSAP CH domain CH_2 PF06294.11 ETO21125.1 - 0.00083 19.4 0.0 0.0042 17.2 0.0 2.3 1 0 0 1 1 1 1 CH-like domain in sperm protein Drf_FH1 PF06346.12 ETO21125.1 - 0.021 14.6 7.1 0.039 13.7 7.1 1.3 1 0 0 1 1 1 0 Formin Homology Region 1 VIT1 PF01988.19 ETO21127.1 - 5e-24 85.4 0.2 7.8e-24 84.7 0.2 1.3 1 1 0 1 1 1 1 VIT family DUF4770 PF15994.5 ETO21128.1 - 3 8.0 6.1 5.8 7.1 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) TMEM208_SND2 PF05620.11 ETO21129.1 - 0.028 14.2 2.3 0.049 13.4 2.2 1.5 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 Orf78 PF06024.12 ETO21129.1 - 0.029 14.6 0.5 0.054 13.8 0.5 1.5 1 0 0 1 1 1 0 Orf78 (ac78) zf-BED PF02892.15 ETO21129.1 - 0.031 14.3 0.2 0.078 13.0 0.2 1.7 1 0 0 1 1 1 0 BED zinc finger zf-C2H2 PF00096.26 ETO21129.1 - 0.041 14.4 0.9 0.14 12.7 0.1 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type SNARE PF05739.19 ETO21129.1 - 0.054 13.5 2.7 0.12 12.4 2.7 1.6 1 0 0 1 1 1 0 SNARE domain DUF2207 PF09972.9 ETO21129.1 - 0.096 11.4 0.1 0.084 11.6 0.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-C2H2_4 PF13894.6 ETO21129.1 - 0.29 12.1 0.1 0.29 12.1 0.1 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger WH1 PF00568.23 ETO21130.1 - 1.3e-11 44.4 1.1 1.9e-11 43.9 0.6 1.5 1 1 0 1 1 1 1 WH1 domain SeqA PF03925.13 ETO21130.1 - 0.00072 19.5 2.4 0.0014 18.6 2.4 1.5 1 0 0 1 1 1 1 SeqA protein C-terminal domain NMT1 PF09084.11 ETO21130.1 - 0.012 15.6 0.2 0.013 15.5 0.2 1.1 1 0 0 1 1 1 0 NMT1/THI5 like Tmemb_9 PF05434.11 ETO21130.1 - 0.024 14.5 3.8 0.024 14.5 3.8 2.1 2 1 0 2 2 2 0 TMEM9 DUF4011 PF13195.6 ETO21130.1 - 0.23 11.4 4.9 0.3 11.0 4.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4011) Ribosomal_L20 PF00453.18 ETO21130.1 - 1.3 9.2 8.9 1.5 8.9 5.3 2.2 2 1 0 2 2 2 0 Ribosomal protein L20 CWC25 PF12542.8 ETO21130.1 - 2.4 9.1 10.3 0.88 10.5 6.4 2.0 2 0 0 2 2 2 0 Pre-mRNA splicing factor HATPase_c_5 PF14501.6 ETO21130.1 - 3.2 7.7 14.9 14 5.7 9.3 2.9 1 1 1 2 2 2 0 GHKL domain DUF2235 PF09994.9 ETO21131.1 - 0.023 14.0 1.3 4.5 6.5 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized alpha/beta hydrolase domain (DUF2235) Apis_Csd PF11671.8 ETO21131.1 - 5.9 6.9 10.7 0.99 9.4 3.5 2.5 2 0 0 2 2 2 0 Complementary sex determiner protein V_ATPase_I PF01496.19 ETO21133.1 - 0.44 8.4 9.5 0.58 8.0 9.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Peptidase_S46 PF10459.9 ETO21133.1 - 2.4 6.7 10.2 2.9 6.4 10.2 1.1 1 0 0 1 1 1 0 Peptidase S46 GpcrRhopsn4 PF10192.9 ETO21133.1 - 4.7 6.5 8.1 6.6 6.1 8.1 1.3 1 0 0 1 1 1 0 Rhodopsin-like GPCR transmembrane domain N_BRCA1_IG PF16158.5 ETO21134.1 - 0.00029 21.5 0.0 0.00052 20.7 0.0 1.4 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene UBA PF00627.31 ETO21134.1 - 0.0023 17.8 0.4 0.0044 16.9 0.4 1.4 1 0 0 1 1 1 1 UBA/TS-N domain HTH_8 PF02954.19 ETO21134.1 - 0.075 12.8 0.1 0.14 11.9 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family 2OG-FeII_Oxy_2 PF13532.6 ETO21136.1 - 8.9e-16 58.7 0.1 1.2e-15 58.3 0.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily tRNA_deacylase PF04414.12 ETO21136.1 - 0.097 12.2 0.0 0.13 11.7 0.0 1.1 1 0 0 1 1 1 0 D-aminoacyl-tRNA deacylase VPS9 PF02204.18 ETO21137.1 - 8e-13 48.5 0.0 1.1e-12 48.1 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain FAD_binding_5 PF00941.21 ETO21138.1 - 0.11 12.2 0.0 0.19 11.5 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain in molybdopterin dehydrogenase DNA_pol_phi PF04931.13 ETO21138.1 - 1 7.4 15.9 0.34 9.0 11.1 1.8 1 1 1 2 2 2 0 DNA polymerase phi WD40 PF00400.32 ETO21139.1 - 7e-43 143.8 6.2 5.4e-10 39.7 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21139.1 - 3.8e-18 65.6 0.2 0.00026 21.2 0.0 4.8 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO21139.1 - 1.5e-09 37.7 5.5 0.00019 20.9 0.0 2.6 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO21139.1 - 1.4e-07 30.8 0.1 0.026 13.5 0.0 3.8 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO21139.1 - 2.5e-07 30.7 0.3 5.2e-06 26.5 0.1 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO21139.1 - 6.6e-07 28.3 0.4 0.17 10.5 0.0 3.8 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO21139.1 - 5.7e-05 22.9 1.8 1.1 9.3 0.1 3.6 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO21139.1 - 0.006 15.2 0.1 2.5 6.5 0.0 2.7 1 1 2 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO21139.1 - 0.0062 16.6 0.0 6.2 6.9 0.0 3.6 1 1 3 4 4 4 1 Family of unknown function (DUF5570) nos_propeller PF18764.1 ETO21139.1 - 0.016 15.1 0.0 18 5.4 0.0 3.9 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat DPPIV_N PF00930.21 ETO21139.1 - 0.02 13.7 0.1 11 4.7 0.0 3.4 2 1 2 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ricin_B_lectin PF00652.22 ETO21139.1 - 0.022 15.0 0.7 0.6 10.4 0.4 2.3 1 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain DUF5125 PF17163.4 ETO21139.1 - 0.039 14.1 0.0 1.3 9.2 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5125) Nbas_N PF15492.6 ETO21139.1 - 0.054 12.8 0.1 0.12 11.7 0.1 1.6 1 1 0 1 1 1 0 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ETO21139.1 - 0.071 12.0 0.8 8 5.3 0.2 2.8 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETO21139.1 - 0.1 12.3 6.1 2.8 7.7 0.1 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Hep_core_N PF08290.11 ETO21139.1 - 0.11 12.5 0.4 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 Hepatitis core protein, putative zinc finger O-ag_pol_Wzy PF14296.6 ETO21141.1 - 0.0017 17.1 0.3 0.0024 16.6 0.3 1.1 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy DUF2615 PF11027.8 ETO21141.1 - 0.12 12.5 0.0 0.21 11.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Ac76 PF05814.11 ETO21141.1 - 0.59 10.2 7.5 1.1 9.3 4.6 2.4 1 1 1 2 2 2 0 Orf76 (Ac76) SLC12 PF03522.15 ETO21142.1 - 0.0024 17.0 11.6 0.0043 16.1 11.6 1.4 1 0 0 1 1 1 1 Solute carrier family 12 ArsP_2 PF11449.8 ETO21142.1 - 0.0059 15.9 0.1 0.013 14.8 0.1 1.5 1 0 0 1 1 1 1 Putative, 10TM heavy-metal exporter Presenilin PF01080.17 ETO21142.1 - 0.014 14.2 8.8 0.026 13.3 8.8 1.4 1 0 0 1 1 1 0 Presenilin PIP5K PF01504.18 ETO21142.1 - 0.016 14.5 8.5 0.04 13.1 8.5 1.7 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase DUF4834 PF16118.5 ETO21142.1 - 0.19 12.7 17.0 0.33 11.9 9.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) EPL1 PF10513.9 ETO21142.1 - 0.32 11.4 15.2 0.2 12.0 6.8 2.5 2 0 0 2 2 2 0 Enhancer of polycomb-like Connexin PF00029.19 ETO21142.1 - 0.39 10.4 10.5 0.15 11.8 4.3 2.3 2 0 0 2 2 2 0 Connexin Gti1_Pac2 PF09729.9 ETO21142.1 - 0.47 10.5 13.1 0.24 11.5 6.0 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family DUF5478 PF17572.2 ETO21142.1 - 0.54 10.4 0.0 0.54 10.4 0.0 2.3 3 0 0 3 3 2 0 Family of unknown function (DUF5478) EFTUD2 PF16004.5 ETO21142.1 - 1.2 9.7 16.9 0.38 11.3 9.7 2.4 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Prothymosin PF03247.14 ETO21142.1 - 1.3 9.5 29.0 1.5 9.3 7.9 2.6 2 0 0 2 2 2 0 Prothymosin/parathymosin family CSG2 PF16965.5 ETO21142.1 - 1.3 7.9 11.6 1.3 7.9 2.5 2.3 2 0 0 2 2 2 0 Ceramide synthase regulator DUF1980 PF09323.10 ETO21142.1 - 1.5 8.7 14.3 2.3 8.1 6.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Spt20 PF12090.8 ETO21142.1 - 2 8.0 30.4 0.64 9.6 19.9 2.2 2 0 0 2 2 2 0 Spt20 family DUF4471 PF14740.6 ETO21142.1 - 3.6 6.7 15.5 2.8 7.1 5.6 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4471) FAM176 PF14851.6 ETO21142.1 - 4.8 6.8 12.2 0.89 9.2 2.6 2.8 3 0 0 3 3 3 0 FAM176 family Tim54 PF11711.8 ETO21142.1 - 5.5 5.7 13.7 0.21 10.3 5.4 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 G0-G1_switch_2 PF15103.6 ETO21142.1 - 7.9 7.0 7.5 0.54 10.7 1.4 2.1 2 0 0 2 2 2 0 G0/G1 switch protein 2 YscJ_FliF_C PF08345.11 ETO21142.1 - 8.6 6.7 19.9 2.3 8.5 0.5 2.4 2 0 0 2 2 2 0 Flagellar M-ring protein C-terminal Utp12 PF04003.12 ETO21143.1 - 0.00084 19.6 3.6 0.0011 19.3 3.6 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family REV1_C PF16727.5 ETO21143.1 - 0.063 13.7 0.9 6.1 7.3 0.3 2.3 1 1 1 2 2 2 0 DNA repair protein REV1 C-terminal domain IL22 PF14565.6 ETO21143.1 - 0.089 13.1 0.6 0.15 12.3 0.1 1.6 2 0 0 2 2 2 0 Interleukin 22 IL-10-related T-cell-derived-inducible factor DUF1764 PF08576.10 ETO21144.1 - 1.2e-14 55.0 0.2 1.2e-14 55.0 0.2 3.9 2 1 0 2 2 2 1 Eukaryotic protein of unknown function (DUF1764) Presenilin PF01080.17 ETO21144.1 - 0.009 14.8 2.6 0.0077 15.0 2.6 1.2 1 0 0 1 1 1 1 Presenilin Neur_chan_memb PF02932.16 ETO21144.1 - 0.069 13.2 15.7 0.095 12.7 15.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DDHD PF02862.17 ETO21144.1 - 0.14 12.2 3.7 0.19 11.9 3.7 1.3 1 0 0 1 1 1 0 DDHD domain RAB3GAP2_C PF14656.6 ETO21144.1 - 0.35 9.0 4.4 0.49 8.5 4.4 1.1 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Glycohydro_20b2 PF14845.6 ETO21144.1 - 0.67 10.6 5.6 1.2 9.8 5.6 1.5 1 0 0 1 1 1 0 beta-acetyl hexosaminidase like Zip PF02535.22 ETO21144.1 - 0.73 9.0 6.3 0.98 8.6 6.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5565 PF17720.1 ETO21144.1 - 1 8.2 7.6 3.5 6.4 0.1 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5565) Dsh_C PF12316.8 ETO21144.1 - 2.4 8.5 4.9 3.7 7.9 4.9 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Pkinase PF00069.25 ETO21145.1 - 1.6e-08 34.3 0.0 1.7e-08 34.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Herpes_UL3 PF03369.13 ETO21147.1 - 0.068 13.7 0.1 0.16 12.5 0.1 1.6 1 0 0 1 1 1 0 Herpesvirus UL3 protein SDA1 PF05285.12 ETO21148.1 - 0.012 15.0 19.9 0.019 14.4 19.9 1.3 1 0 0 1 1 1 0 SDA1 RGS PF00615.19 ETO21148.1 - 0.19 12.0 0.0 0.19 12.0 0.0 2.2 2 1 0 2 2 2 0 Regulator of G protein signaling domain Nop14 PF04147.12 ETO21148.1 - 0.83 7.8 23.1 1.3 7.1 23.1 1.3 1 0 0 1 1 1 0 Nop14-like family RNA_polI_A34 PF08208.11 ETO21148.1 - 1.2 9.2 11.8 1.7 8.7 11.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Hid1 PF12722.7 ETO21148.1 - 7.2 4.6 7.8 9.2 4.3 7.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DSPc PF00782.20 ETO21150.1 - 2.5e-07 30.6 0.0 2.9e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO21150.1 - 1.6e-06 27.9 0.0 2e-06 27.5 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETO21150.1 - 0.028 14.5 0.0 0.037 14.1 0.0 1.2 1 0 0 1 1 1 0 Inositol hexakisphosphate CDKN3 PF05706.12 ETO21150.1 - 0.064 12.9 0.0 0.14 11.9 0.0 1.6 1 1 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) CAP_GLY PF01302.25 ETO21152.1 - 4.8e-10 39.3 0.2 1e-09 38.3 0.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain XAP5 PF04921.14 ETO21152.1 - 1.3 8.8 13.5 2.5 7.9 0.3 2.4 2 0 0 2 2 2 0 XAP5, circadian clock regulator WD40 PF00400.32 ETO21153.1 - 8.3e-21 73.9 15.2 0.00023 21.9 0.0 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21153.1 - 4.3e-05 23.7 0.2 18 5.7 0.0 4.9 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO21153.1 - 0.016 14.5 0.3 1.3 8.3 0.1 3.5 2 2 1 3 3 3 0 WD40-like domain Emaravirus_P4 PF16505.5 ETO21153.1 - 0.037 13.1 0.0 0.1 11.6 0.0 1.6 2 0 0 2 2 2 0 P4 movement protein of Emaravirus, and the 30K superfamily CHD5 PF04420.14 ETO21153.1 - 0.3 11.0 0.1 0.3 11.0 0.1 2.5 3 0 0 3 3 3 0 CHD5-like protein CENP-B_dimeris PF09026.10 ETO21154.1 - 8.3 6.9 9.8 26 5.3 0.0 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PX PF00787.24 ETO21155.1 - 3.4e-07 30.2 0.3 1.3e-06 28.3 0.0 2.2 2 1 0 2 2 2 1 PX domain AgrB PF04647.15 ETO21155.1 - 0.091 12.1 3.1 0.16 11.3 3.1 1.3 1 0 0 1 1 1 0 Accessory gene regulator B PPDFL PF15060.6 ETO21156.1 - 2.9 8.5 7.5 6 7.4 2.2 2.3 2 0 0 2 2 2 0 Differentiation and proliferation regulator Ras PF00071.22 ETO21157.1 - 3e-19 69.2 0.1 3.5e-19 69.0 0.1 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO21157.1 - 0.048 13.9 0.0 0.074 13.3 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Mei4 PF13971.6 ETO21157.1 - 0.051 13.1 0.2 0.054 13.0 0.2 1.1 1 0 0 1 1 1 0 Meiosis-specific protein Mei4 RsgA_GTPase PF03193.16 ETO21157.1 - 0.059 13.3 0.0 0.077 12.9 0.0 1.1 1 0 0 1 1 1 0 RsgA GTPase FeoB_N PF02421.18 ETO21157.1 - 0.06 12.9 0.3 6.7 6.2 0.1 2.2 1 1 1 2 2 2 0 Ferrous iron transport protein B STAS PF01740.21 ETO21157.1 - 0.067 12.8 0.1 0.12 12.0 0.1 1.4 1 0 0 1 1 1 0 STAS domain polyprenyl_synt PF00348.17 ETO21158.1 - 9.6e-35 119.9 0.4 1.4e-18 66.9 0.1 2.8 1 1 1 2 2 2 2 Polyprenyl synthetase ArsC PF03960.15 ETO21158.1 - 0.0086 16.1 0.0 0.035 14.1 0.0 2.1 2 1 0 2 2 2 1 ArsC family Orn_Arg_deC_N PF02784.16 ETO21159.1 - 5.1e-56 189.8 0.0 6.4e-56 189.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ETO21159.1 - 5.6e-25 87.4 0.0 6.4e-25 87.3 0.0 1.2 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain Ala_racemase_N PF01168.20 ETO21159.1 - 0.016 14.8 0.0 0.032 13.9 0.0 1.5 1 0 0 1 1 1 0 Alanine racemase, N-terminal domain LPG_synthase_TM PF03706.13 ETO21160.1 - 2.6e-13 50.2 20.5 3.9e-11 43.0 20.5 2.1 1 1 0 1 1 1 1 Lysylphosphatidylglycerol synthase TM region ANAPC3 PF12895.7 ETO21161.1 - 0.0038 17.4 4.4 1.4 9.2 0.0 3.9 5 0 0 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 mRNA_stabil PF13929.6 ETO21161.1 - 0.014 14.4 0.2 0.031 13.3 0.2 1.6 1 0 0 1 1 1 0 mRNA stabilisation Ank_2 PF12796.7 ETO21162.1 - 0.0065 17.0 0.1 0.79 10.4 0.0 2.3 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO21162.1 - 0.0082 16.7 0.0 6.4 7.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21162.1 - 0.012 16.1 0.1 2.2 9.1 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat ABC2_membrane_3 PF12698.7 ETO21162.1 - 0.032 13.4 0.1 0.044 12.9 0.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein Ank_5 PF13857.6 ETO21162.1 - 0.19 12.1 0.0 0.87 10.0 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (many copies) KaiB PF07689.12 ETO21163.1 - 0.02 14.6 0.0 0.098 12.4 0.0 2.3 1 0 0 1 1 1 0 KaiB domain DUF948 PF06103.11 ETO21163.1 - 0.26 11.6 1.6 8.9 6.6 0.4 3.6 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) POX PF07526.11 ETO21163.1 - 5.2 7.6 14.1 0.18 12.3 6.5 2.6 3 0 0 3 3 3 0 Associated with HOX RasGEF PF00617.19 ETO21164.1 - 3e-09 37.3 8.2 0.00034 20.9 0.0 3.5 2 1 1 3 3 3 2 RasGEF domain RasGEF_N PF00618.20 ETO21164.1 - 0.0027 17.9 0.1 0.0027 17.9 0.1 2.7 2 1 0 2 2 2 1 RasGEF N-terminal motif Apis_Csd PF11671.8 ETO21164.1 - 0.051 13.6 4.8 0.44 10.6 1.3 2.6 3 0 0 3 3 3 0 Complementary sex determiner protein Kelch_1 PF01344.25 ETO21165.1 - 0.067 12.8 0.7 0.61 9.7 0.5 2.8 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO21165.1 - 0.25 11.7 7.2 2.2 8.7 0.1 4.2 6 0 0 6 6 6 0 Kelch motif AD PF09793.9 ETO21166.1 - 7.7e-07 29.2 0.1 7.7e-07 29.2 0.1 2.3 3 0 0 3 3 3 1 Anticodon-binding domain PaaB PF06243.11 ETO21167.1 - 0.024 14.9 0.0 0.036 14.3 0.0 1.6 1 1 0 1 1 1 0 Phenylacetic acid degradation B Laminin_G_3 PF13385.6 ETO21169.1 - 1.1e-06 28.9 0.2 2e-06 28.0 0.2 1.4 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily PMM PF03332.13 ETO21169.1 - 0.2 11.4 0.1 0.37 10.5 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic phosphomannomutase NOA36 PF06524.12 ETO21170.1 - 0.024 14.0 36.4 0.021 14.2 13.6 2.1 2 0 0 2 2 2 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 ETO21170.1 - 0.36 11.1 41.8 0.27 11.4 19.4 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 RXT2_N PF08595.11 ETO21170.1 - 1.9 8.5 38.2 0.067 13.2 13.3 2.3 1 1 0 2 2 2 0 RXT2-like, N-terminal BUD22 PF09073.10 ETO21170.1 - 3.2 7.0 41.2 4.6 6.5 41.2 1.3 1 0 0 1 1 1 0 BUD22 PIEZO PF15917.5 ETO21170.1 - 6.3 6.2 25.5 0.72 9.3 3.4 2.2 2 0 0 2 2 2 0 Piezo DUF4746 PF15928.5 ETO21170.1 - 8.2 5.7 42.1 0.99 8.8 17.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) ABC_membrane PF00664.23 ETO21171.1 - 3.5e-08 33.4 0.4 5.7e-08 32.7 0.4 1.3 1 0 0 1 1 1 1 ABC transporter transmembrane region ABC_tran PF00005.27 ETO21171.1 - 4.1e-08 33.8 0.0 4.1e-08 33.8 0.0 2.2 2 1 0 2 2 2 1 ABC transporter SbcCD_C PF13558.6 ETO21171.1 - 0.012 15.9 0.3 0.86 9.9 0.0 3.2 3 0 0 3 3 3 0 Putative exonuclease SbcCD, C subunit DUF2981 PF11200.8 ETO21171.1 - 0.076 12.8 7.8 0.11 12.2 7.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) DUF3439 PF11921.8 ETO21171.1 - 0.37 10.8 14.2 0.88 9.6 14.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) cNMP_binding PF00027.29 ETO21172.1 - 8.8e-24 83.4 0.1 4.2e-14 52.4 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain TFIIA PF03153.13 ETO21173.1 - 0.13 12.3 20.3 0.15 12.0 20.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Ldh_1_N PF00056.23 ETO21175.1 - 1.1e-34 119.5 0.0 1.4e-34 119.2 0.0 1.1 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain UPF0146 PF03686.13 ETO21176.1 - 0.088 12.7 0.0 0.095 12.6 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) zf-C3HC4_3 PF13920.6 ETO21177.1 - 0.6 10.0 8.1 3.6 7.5 8.1 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) FlxA PF14282.6 ETO21177.1 - 4.5 7.3 14.7 7.4 6.6 11.2 2.6 2 1 0 2 2 2 0 FlxA-like protein B56 PF01603.20 ETO21178.1 - 2e-109 366.4 7.4 2.3e-109 366.1 7.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) KCT2 PF17818.1 ETO21178.1 - 0.023 14.8 0.0 0.042 14.0 0.0 1.4 1 0 0 1 1 1 0 Keratinocyte-associated gene product ECD PF18432.1 ETO21178.1 - 0.048 13.6 0.0 0.093 12.7 0.0 1.4 1 0 0 1 1 1 0 Extracellular Cadherin domain G-alpha PF00503.20 ETO21179.1 - 4.3e-64 216.9 22.0 1.9e-33 116.1 6.1 2.0 2 0 0 2 2 2 2 G-protein alpha subunit DUF815 PF05673.13 ETO21179.1 - 0.0076 15.4 0.2 0.012 14.8 0.2 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF815) NB-ARC PF00931.22 ETO21179.1 - 0.0085 15.3 0.1 0.017 14.3 0.1 1.5 1 0 0 1 1 1 1 NB-ARC domain Roc PF08477.13 ETO21179.1 - 0.0092 16.2 1.2 6.1 7.1 0.0 3.0 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase FtsK_SpoIIIE PF01580.18 ETO21179.1 - 0.011 15.1 0.1 0.024 14.0 0.1 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 ETO21179.1 - 0.021 14.6 0.2 0.039 13.7 0.2 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO21179.1 - 0.061 13.8 3.1 0.16 12.5 2.9 1.8 1 1 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ETO21179.1 - 0.079 13.5 1.0 0.34 11.5 1.0 2.2 1 1 0 1 1 1 0 AAA domain RNA_pol_3_Rpc31 PF11705.8 ETO21181.1 - 0.017 15.4 9.6 0.029 14.6 9.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DNA_pol_phi PF04931.13 ETO21181.1 - 1 7.4 13.4 1.3 7.0 13.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi zf-RING_9 PF13901.6 ETO21182.1 - 1.2e-13 51.5 7.0 3.4e-11 43.5 1.1 3.2 3 0 0 3 3 3 2 Putative zinc-RING and/or ribbon WD40 PF00400.32 ETO21183.1 - 8.6e-40 134.0 23.9 7.7e-08 32.9 0.2 7.5 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21183.1 - 8.8e-18 64.4 0.4 0.0057 16.9 0.0 5.3 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO21183.1 - 6.9e-07 28.3 1.5 0.11 11.2 0.0 4.7 1 1 2 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO21183.1 - 2.8e-05 23.6 3.2 0.33 10.2 0.2 4.1 3 1 1 4 4 4 2 WD40-like domain PIEZO PF15917.5 ETO21183.1 - 0.19 11.2 2.2 0.29 10.6 2.2 1.3 1 0 0 1 1 1 0 Piezo Peptidase_U49 PF10463.9 ETO21183.1 - 0.41 10.4 5.1 0.59 9.9 5.1 1.2 1 0 0 1 1 1 0 Peptidase U49 SOGA PF11365.8 ETO21183.1 - 3.7 8.7 7.2 6.6 7.9 7.2 1.3 1 0 0 1 1 1 0 Protein SOGA zf-TRAF PF02176.18 ETO21184.1 - 8.7e-07 29.5 1.5 8.7e-07 29.5 1.5 3.0 2 1 0 2 2 2 1 TRAF-type zinc finger zf-C2H2 PF00096.26 ETO21186.1 - 7.2e-17 60.8 29.9 1e-05 25.7 0.3 6.4 6 0 0 6 6 6 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO21186.1 - 3.6e-14 52.2 32.1 0.0007 20.2 0.3 6.4 6 0 0 6 6 6 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO21186.1 - 1e-10 41.5 24.7 0.0039 17.6 0.4 6.4 6 0 0 6 6 6 3 Zinc-finger double domain zf-Di19 PF05605.12 ETO21186.1 - 2.8e-05 24.3 4.1 2.8e-05 24.3 4.1 4.2 2 2 1 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_jaz PF12171.8 ETO21186.1 - 0.00013 22.1 1.4 0.00013 22.1 1.4 5.6 6 0 0 6 6 5 1 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETO21186.1 - 0.0026 18.1 0.3 0.0026 18.1 0.3 6.0 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_3rep PF18868.1 ETO21186.1 - 0.003 18.2 18.2 0.2 12.4 2.0 4.3 1 1 2 4 4 4 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 ETO21186.1 - 0.0065 16.4 21.9 0.017 15.1 0.3 5.2 5 0 0 5 5 5 2 C2H2-type zinc finger zf_UBZ PF18439.1 ETO21186.1 - 0.048 13.3 0.4 0.048 13.3 0.4 4.0 4 0 0 4 4 4 0 Ubiquitin-Binding Zinc Finger zf-BED PF02892.15 ETO21186.1 - 0.15 12.1 24.5 2 8.5 3.6 5.5 4 2 2 6 6 6 0 BED zinc finger zinc_ribbon_9 PF14369.6 ETO21186.1 - 0.23 11.7 7.9 3.8 7.8 0.1 3.7 4 0 0 4 4 4 0 zinc-ribbon zf-H2C2_5 PF13909.6 ETO21186.1 - 0.34 10.7 24.7 0.37 10.6 0.5 5.4 5 2 0 5 5 5 0 C2H2-type zinc-finger domain Zn-ribbon_8 PF09723.10 ETO21186.1 - 0.34 11.1 10.8 0.95 9.6 0.2 4.2 4 0 0 4 4 4 0 Zinc ribbon domain zf_Hakai PF18408.1 ETO21186.1 - 0.39 10.5 13.3 1.1 9.0 0.0 4.4 4 1 0 4 4 4 0 C2H2 Hakai zinc finger domain GAGA PF09237.11 ETO21186.1 - 0.62 9.9 19.3 5.1 7.0 0.1 5.1 3 2 2 5 5 5 0 GAGA factor Mga PF05043.13 ETO21186.1 - 0.88 10.2 3.7 29 5.3 0.1 3.0 3 0 0 3 3 3 0 Mga helix-turn-helix domain zf-C2H2_2 PF12756.7 ETO21186.1 - 1 9.8 24.9 2.6 8.4 1.3 3.7 1 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) zf_ZIC PF18366.1 ETO21186.1 - 5.6 7.2 9.8 1.5 8.9 0.3 3.5 3 1 0 3 3 3 0 Zic proteins zinc finger domain zf-MYST PF17772.1 ETO21186.1 - 6 6.6 16.4 1.7 8.3 1.8 3.9 4 1 0 4 4 4 0 MYST family zinc finger domain C1_1 PF00130.22 ETO21186.1 - 7.5 6.5 21.6 2.3 8.2 3.8 4.2 3 1 2 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) VPS9 PF02204.18 ETO21187.1 - 1.1e-12 48.1 0.1 3.6e-12 46.4 0.0 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain RAP1 PF07218.11 ETO21188.1 - 0.0095 14.3 3.3 0.013 13.8 3.3 1.2 1 0 0 1 1 1 1 Rhoptry-associated protein 1 (RAP-1) MBT PF02820.18 ETO21189.1 - 1.5e-05 25.2 0.9 5.5e-05 23.4 0.2 2.1 2 0 0 2 2 2 1 mbt repeat Tudor_FRX1 PF18336.1 ETO21189.1 - 0.0033 17.3 0.1 0.0079 16.1 0.1 1.6 1 0 0 1 1 1 1 Fragile X mental retardation Tudor domain Coiled-coil_56 PF09813.9 ETO21189.1 - 0.0072 16.4 0.0 5 7.2 0.1 2.3 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 56 Brr6_like_C_C PF10104.9 ETO21189.1 - 0.046 13.5 0.3 0.074 12.8 0.3 1.3 1 0 0 1 1 1 0 Di-sulfide bridge nucleocytoplasmic transport domain Tudor-knot PF11717.8 ETO21189.1 - 0.071 13.0 0.9 0.19 11.6 0.2 2.2 2 0 0 2 2 2 0 RNA binding activity-knot of a chromodomain Snf7 PF03357.21 ETO21192.1 - 1.1e-05 25.1 10.9 1.4e-05 24.8 10.9 1.0 1 0 0 1 1 1 1 Snf7 APG6_N PF17675.1 ETO21192.1 - 0.0021 18.6 2.9 0.0021 18.6 2.9 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region YabA PF06156.13 ETO21192.1 - 0.019 15.6 3.5 0.025 15.2 3.5 1.2 1 0 0 1 1 1 0 Initiation control protein YabA TMPIT PF07851.13 ETO21192.1 - 0.021 14.1 4.7 0.022 14.0 4.7 1.0 1 0 0 1 1 1 0 TMPIT-like protein ATP-synt_D PF01813.17 ETO21192.1 - 0.033 14.0 6.0 0.038 13.8 6.0 1.0 1 0 0 1 1 1 0 ATP synthase subunit D DUF2072 PF09845.9 ETO21192.1 - 0.094 13.0 2.6 0.11 12.8 2.6 1.0 1 0 0 1 1 1 0 Zn-ribbon containing protein DivIC PF04977.15 ETO21192.1 - 0.12 12.2 8.7 0.14 11.9 5.9 2.1 2 0 0 2 2 2 0 Septum formation initiator DUF4407 PF14362.6 ETO21192.1 - 0.13 11.6 3.9 0.14 11.5 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Hist_deacetyl PF00850.19 ETO21192.1 - 0.14 11.6 0.5 0.16 11.5 0.5 1.0 1 0 0 1 1 1 0 Histone deacetylase domain DUF2229 PF09989.9 ETO21192.1 - 0.15 11.7 1.3 0.16 11.6 1.3 1.1 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) HAUS6_N PF14661.6 ETO21192.1 - 0.16 11.6 5.0 0.16 11.5 5.0 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DUF5595 PF18077.1 ETO21192.1 - 0.16 12.1 2.7 0.24 11.5 2.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) ZapB PF06005.12 ETO21192.1 - 0.16 12.4 8.3 0.23 11.9 8.3 1.3 1 0 0 1 1 1 0 Cell division protein ZapB CENP-H PF05837.12 ETO21192.1 - 0.17 12.3 7.7 0.19 12.1 7.7 1.1 1 0 0 1 1 1 0 Centromere protein H (CENP-H) DUF4140 PF13600.6 ETO21192.1 - 0.38 11.2 4.2 0.59 10.6 4.2 1.3 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) Sec20 PF03908.13 ETO21192.1 - 0.41 10.6 4.3 2.4 8.1 0.1 2.1 1 1 1 2 2 2 0 Sec20 SlyX PF04102.12 ETO21192.1 - 0.84 10.3 6.4 1.2 9.8 5.9 1.6 1 1 0 1 1 1 0 SlyX Bac_export_2 PF01312.19 ETO21192.1 - 1.8 7.7 8.8 0.52 9.5 3.5 2.0 1 1 1 2 2 2 0 FlhB HrpN YscU SpaS Family zf-CCHC_4 PF14392.6 ETO21193.1 - 0.072 12.8 0.6 0.16 11.7 0.6 1.5 1 0 0 1 1 1 0 Zinc knuckle zinc_ribbon_10 PF10058.9 ETO21193.1 - 0.13 12.1 3.0 0.36 10.6 3.0 1.7 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein zf-CCHC PF00098.23 ETO21193.1 - 6.7 7.0 6.5 0.69 10.1 1.8 1.9 2 0 0 2 2 2 0 Zinc knuckle WD40 PF00400.32 ETO21194.1 - 0.0021 18.8 0.9 0.0068 17.2 0.1 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF2572 PF10833.8 ETO21195.1 - 0.012 15.4 0.4 0.018 14.8 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2572) PAP_RNA-bind PF04926.15 ETO21196.1 - 0.03 14.0 3.6 0.088 12.4 3.6 1.8 1 1 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain P_gingi_FimA PF06321.11 ETO21196.1 - 0.073 13.2 0.7 2.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Major fimbrial subunit protein (FimA) Melibiase_C PF17801.1 ETO21196.1 - 0.11 12.6 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 Alpha galactosidase C-terminal beta sandwich domain CCD48 PF15799.5 ETO21196.1 - 0.18 10.1 0.3 0.26 9.5 0.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 48 DUF3298 PF11738.8 ETO21196.1 - 0.24 12.5 1.0 31 5.7 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3298) Peptidase_S49_N PF08496.10 ETO21196.1 - 1.5 8.8 5.7 3.1 7.9 5.7 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Med19 PF10278.9 ETO21198.1 - 0.011 15.7 4.7 0.011 15.7 4.7 2.0 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Apt1 PF10351.9 ETO21198.1 - 0.078 11.8 18.8 0.097 11.5 18.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain NOA36 PF06524.12 ETO21198.1 - 0.55 9.5 12.3 0.85 8.9 12.3 1.3 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ETO21198.1 - 0.71 8.1 13.4 0.96 7.7 13.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 ETO21198.1 - 1 7.4 16.0 1.2 7.2 16.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RRN3 PF05327.11 ETO21198.1 - 1.3 7.5 8.1 1.4 7.4 8.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 PI3K_1B_p101 PF10486.9 ETO21198.1 - 2.7 5.7 14.5 3.1 5.5 14.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LAP1C PF05609.12 ETO21198.1 - 4.8 6.2 21.3 5.5 6.0 21.3 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SRP-alpha_N PF04086.13 ETO21198.1 - 5.7 6.8 24.0 6.7 6.5 24.0 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal RPN2_C PF18004.1 ETO21198.1 - 9.5 6.1 18.2 1.4 8.9 9.2 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain SARAF PF06682.12 ETO21199.1 - 0.093 12.4 4.6 0.12 12.0 4.6 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Macoilin PF09726.9 ETO21199.1 - 0.68 8.4 3.9 0.83 8.1 3.9 1.2 1 0 0 1 1 1 0 Macoilin family Alpha_kinase PF02816.18 ETO21200.1 - 5.3e-47 160.3 0.4 1.1e-46 159.3 0.4 1.6 1 0 0 1 1 1 1 Alpha-kinase family SlyX PF04102.12 ETO21201.1 - 0.11 13.1 2.7 0.18 12.5 2.7 1.3 1 0 0 1 1 1 0 SlyX GET2 PF08690.10 ETO21202.1 - 0.0033 17.1 0.1 0.0056 16.4 0.1 1.5 1 0 0 1 1 1 1 GET complex subunit GET2 DUF608 PF04685.13 ETO21202.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.2 1 0 0 1 1 1 0 Glycosyl-hydrolase family 116, catalytic region OTCace_N PF02729.21 ETO21203.1 - 1.8e-37 128.6 0.0 2.3e-37 128.3 0.0 1.1 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain Kelch_3 PF13415.6 ETO21204.1 - 1.4e-05 25.2 0.3 0.019 15.2 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO21204.1 - 3e-05 23.5 5.2 0.11 12.1 0.3 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO21204.1 - 0.00017 21.5 4.4 0.0081 16.1 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO21204.1 - 0.00023 21.1 2.7 0.02 14.9 0.0 4.3 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO21204.1 - 0.00047 20.4 5.0 0.41 11.0 0.2 4.8 5 1 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO21204.1 - 0.12 12.4 0.3 0.63 10.1 0.2 2.2 2 0 0 2 2 2 0 Kelch motif FH2 PF02181.23 ETO21205.1 - 1.1e-16 61.0 2.8 1.1e-16 61.0 2.8 2.0 1 1 1 2 2 2 1 Formin Homology 2 Domain Presenilin PF01080.17 ETO21205.1 - 0.91 8.2 5.5 1.2 7.8 5.5 1.2 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO21205.1 - 1.8 7.3 9.4 2.2 7.0 9.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4011 PF13195.6 ETO21205.1 - 2.2 8.2 8.1 13 5.6 7.9 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4011) Neur_chan_memb PF02932.16 ETO21205.1 - 5.3 7.0 7.8 7.7 6.5 7.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FH2 PF02181.23 ETO21206.1 - 4.6e-59 200.4 0.2 2e-58 198.3 0.2 2.0 1 1 0 1 1 1 1 Formin Homology 2 Domain CCDC53 PF10152.9 ETO21206.1 - 1e-11 45.5 5.5 3.2e-07 30.9 0.2 5.2 5 1 0 5 5 5 2 Subunit CCDC53 of WASH complex Drf_GBD PF06371.13 ETO21206.1 - 1.6e-07 31.1 0.1 7.4e-07 28.9 0.0 2.2 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Drf_FH3 PF06367.16 ETO21206.1 - 0.00013 21.7 0.0 0.00055 19.6 0.0 2.1 1 0 0 1 1 1 1 Diaphanous FH3 Domain CAP_GLY PF01302.25 ETO21207.1 - 7.5e-13 48.3 0.4 1.6e-12 47.2 0.4 1.6 1 0 0 1 1 1 1 CAP-Gly domain RE_NgoFVII PF09565.10 ETO21207.1 - 0.025 13.9 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 NgoFVII restriction endonuclease PKHD_C PF18331.1 ETO21207.1 - 0.076 13.1 0.1 0.2 11.8 0.1 1.7 1 0 0 1 1 1 0 PKHD-type hydroxylase C-terminal domain DUF2722 PF10846.8 ETO21209.1 - 0.00081 18.5 16.3 0.00081 18.5 16.3 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Corona_nucleoca PF00937.18 ETO21209.1 - 0.00095 18.3 9.5 0.00095 18.3 9.5 1.7 2 0 0 2 2 2 1 Coronavirus nucleocapsid protein Nucleo_P87 PF07267.11 ETO21209.1 - 0.094 11.6 14.7 0.19 10.5 14.7 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 GCIP PF13324.6 ETO21209.1 - 1.7 8.1 6.8 0.42 10.2 3.2 1.8 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting Transformer PF06495.11 ETO21209.1 - 4.8 7.2 29.1 0.12 12.5 21.1 2.4 3 0 0 3 3 3 0 Fruit fly transformer protein TP2 PF01254.18 ETO21209.1 - 5.2 7.7 25.2 0.65 10.6 14.4 2.7 2 0 0 2 2 2 0 Nuclear transition protein 2 PDZ_3 PF17815.1 ETO21210.1 - 2.4e-23 82.6 0.0 4.2e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO21210.1 - 1.8e-09 37.8 0.0 1.4e-08 34.9 0.0 2.1 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ETO21210.1 - 0.0036 17.6 0.0 0.0091 16.3 0.0 1.6 2 0 0 2 2 2 1 PDZ domain PDZ_6 PF17820.1 ETO21210.1 - 0.0089 15.8 0.0 0.026 14.3 0.0 1.8 2 0 0 2 2 2 1 PDZ domain RasGEF PF00617.19 ETO21211.1 - 2.6e-06 27.8 0.2 5.4e-06 26.7 0.1 1.6 2 0 0 2 2 2 1 RasGEF domain GBV-C_env PF12786.7 ETO21211.1 - 0.081 11.6 0.0 0.11 11.2 0.0 1.2 1 0 0 1 1 1 0 GB virus C genotype envelope Ribul_P_3_epim PF00834.19 ETO21212.1 - 2.1e-63 213.3 0.5 1.7e-62 210.3 0.5 2.0 1 1 0 1 1 1 1 Ribulose-phosphate 3 epimerase family Drf_GBD PF06371.13 ETO21212.1 - 0.048 13.2 0.1 0.1 12.2 0.1 1.5 1 0 0 1 1 1 0 Diaphanous GTPase-binding Domain QRPTase_C PF01729.19 ETO21212.1 - 0.13 12.0 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 Quinolinate phosphoribosyl transferase, C-terminal domain WD40 PF00400.32 ETO21213.1 - 2.1e-40 136.0 9.2 1.7e-09 38.2 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21213.1 - 6.6e-13 48.8 1.0 0.2 12.0 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21213.1 - 4.3e-09 35.8 0.4 0.017 14.1 0.0 4.7 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO21213.1 - 0.002 16.7 0.1 0.096 11.2 0.1 2.3 2 0 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO21213.1 - 0.0021 18.0 0.7 33 4.6 0.0 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO21213.1 - 0.0055 16.3 0.2 0.48 10.0 0.0 2.5 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Nbas_N PF15492.6 ETO21213.1 - 0.0057 16.0 1.1 0.7 9.2 0.0 3.3 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PQQ PF01011.21 ETO21213.1 - 0.0078 16.1 0.0 6.8 6.8 0.0 4.4 6 0 0 6 6 6 1 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETO21213.1 - 1.2 8.8 6.3 67 3.3 0.1 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Uso1_p115_C PF04871.13 ETO21214.1 - 0.015 15.7 7.2 0.015 15.7 7.2 2.7 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Sin3_corepress PF08295.12 ETO21214.1 - 0.43 10.7 10.0 0.52 10.4 4.9 2.5 2 0 0 2 2 2 0 Sin3 family co-repressor DUF489 PF04356.12 ETO21214.1 - 0.88 9.6 6.0 0.16 12.0 0.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF489) TACC_C PF05010.14 ETO21214.1 - 1 9.1 19.9 0.44 10.3 10.1 2.5 2 0 0 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF4164 PF13747.6 ETO21214.1 - 1.4 9.3 10.3 2.6 8.4 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4164) TPR_MLP1_2 PF07926.12 ETO21214.1 - 1.5 8.9 23.5 0.22 11.6 12.1 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein LMBR1 PF04791.16 ETO21214.1 - 1.9 7.3 6.4 2.8 6.7 6.4 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF724 PF05266.14 ETO21214.1 - 3.5 7.4 14.6 7.3 6.4 5.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF724) SKA2 PF16740.5 ETO21214.1 - 6.1 6.7 19.8 9.5 6.1 3.7 3.3 3 0 0 3 3 3 0 Spindle and kinetochore-associated protein 2 OmpH PF03938.14 ETO21214.1 - 6.9 7.0 21.2 2.8 8.3 4.9 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF948 PF06103.11 ETO21214.1 - 8.8 6.7 11.3 0.23 11.7 0.6 3.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Clat_adaptor_s PF01217.20 ETO21215.1 - 1.6e-06 28.1 0.1 2.4e-06 27.5 0.1 1.3 1 0 0 1 1 1 1 Clathrin adaptor complex small chain DUF5586 PF17824.1 ETO21215.1 - 0.017 14.3 0.2 0.026 13.6 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5586) Mito_fiss_reg PF05308.11 ETO21216.1 - 0.18 11.9 1.9 0.27 11.3 1.9 1.2 1 0 0 1 1 1 0 Mitochondrial fission regulator HEAT PF02985.22 ETO21217.1 - 0.013 15.7 0.1 2.4 8.7 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat DUF2431 PF10354.9 ETO21218.1 - 1e-11 45.4 0.1 1.4e-11 45.0 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) Actin PF00022.19 ETO21219.1 - 5.5e-71 239.3 0.0 9.3e-71 238.6 0.0 1.3 1 1 0 1 1 1 1 Actin Lsm_C PF14894.6 ETO21220.1 - 0.12 12.2 0.3 14 5.5 0.0 2.3 2 0 0 2 2 2 0 Lsm C-terminal Amdo_NSP PF12475.8 ETO21220.1 - 0.6 10.2 3.9 2.4 8.3 0.2 2.5 2 1 0 2 2 2 0 Amdovirus non-structural protein zf-TRAF PF02176.18 ETO21221.1 - 0.001 19.7 10.1 0.001 19.7 10.1 3.7 3 1 1 4 4 4 2 TRAF-type zinc finger zf-CCHC PF00098.23 ETO21221.1 - 0.029 14.4 0.3 0.029 14.4 0.3 4.0 4 0 0 4 4 4 0 Zinc knuckle zf-CCHC_5 PF14787.6 ETO21221.1 - 0.91 9.3 9.8 0.22 11.2 0.7 3.3 3 0 0 3 3 3 0 GAG-polyprotein viral zinc-finger zf-CCHC_3 PF13917.6 ETO21221.1 - 8.9 6.4 15.7 2.2 8.3 2.5 3.7 3 0 0 3 3 3 0 Zinc knuckle CDC45 PF02724.14 ETO21223.1 - 3.4 5.9 8.1 4 5.6 8.1 1.0 1 0 0 1 1 1 0 CDC45-like protein OHCU_decarbox PF09349.10 ETO21225.1 - 0.015 15.8 3.0 0.019 15.4 3.0 1.2 1 0 0 1 1 1 0 OHCU decarboxylase RNA_pol_3_Rpc31 PF11705.8 ETO21225.1 - 0.015 15.5 9.9 0.018 15.3 9.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Sporozoite_P67 PF05642.11 ETO21225.1 - 0.015 13.4 4.9 0.018 13.2 4.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4746 PF15928.5 ETO21225.1 - 0.016 14.7 9.9 0.017 14.6 9.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PPP4R2 PF09184.11 ETO21225.1 - 0.018 14.6 7.0 0.023 14.3 7.0 1.1 1 0 0 1 1 1 0 PPP4R2 DUF4820 PF16091.5 ETO21225.1 - 0.039 13.3 2.3 0.049 13.0 2.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF2052 PF09747.9 ETO21225.1 - 0.042 14.0 11.5 0.044 13.9 10.8 1.4 2 0 0 2 2 1 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO21225.1 - 0.045 12.1 6.0 0.044 12.1 6.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nucleo_P87 PF07267.11 ETO21225.1 - 0.049 12.5 6.9 0.063 12.1 6.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FAM176 PF14851.6 ETO21225.1 - 0.064 12.9 7.8 0.092 12.4 7.8 1.3 1 0 0 1 1 1 0 FAM176 family Peptidase_S49_N PF08496.10 ETO21225.1 - 0.18 11.8 4.6 0.26 11.3 4.6 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Astro_capsid_p PF12226.8 ETO21225.1 - 0.22 10.7 6.4 0.25 10.5 6.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein RXT2_N PF08595.11 ETO21225.1 - 0.33 11.0 7.3 0.46 10.5 7.3 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 ETO21225.1 - 0.38 11.2 11.1 0.24 11.8 9.3 1.6 1 1 0 1 1 1 0 Centromere protein B dimerisation domain SID-1_RNA_chan PF13965.6 ETO21225.1 - 0.44 8.9 1.0 0.51 8.7 1.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 ETO21225.1 - 0.56 8.1 3.6 0.66 7.8 3.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family NOA36 PF06524.12 ETO21225.1 - 0.58 9.4 9.7 0.78 9.0 9.7 1.1 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 ETO21225.1 - 0.82 8.8 5.9 1 8.5 5.9 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CobT PF06213.12 ETO21225.1 - 0.83 9.0 14.3 1.1 8.6 14.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TMEM51 PF15345.6 ETO21225.1 - 0.97 9.2 5.6 1.7 8.4 5.6 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 FUSC-like PF12805.7 ETO21225.1 - 1.6 7.8 4.0 1.2 8.2 2.6 1.4 1 1 0 1 1 1 0 FUSC-like inner membrane protein yccS DNA_pol_phi PF04931.13 ETO21225.1 - 1.7 6.6 14.6 2 6.4 14.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi GOLD_2 PF13897.6 ETO21225.1 - 3.7 8.0 6.3 5.4 7.5 5.8 1.5 1 1 0 1 1 1 0 Golgi-dynamics membrane-trafficking Presenilin PF01080.17 ETO21225.1 - 5 5.8 5.1 5.1 5.8 5.1 1.1 1 0 0 1 1 1 0 Presenilin PH PF00169.29 ETO21226.1 - 0.00091 19.7 0.5 0.014 15.9 0.0 2.4 2 0 0 2 2 2 1 PH domain PH_6 PF15406.6 ETO21226.1 - 0.026 14.8 1.1 0.084 13.2 0.1 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain GAPT PF11770.8 ETO21226.1 - 0.037 13.9 0.1 0.037 13.9 0.1 1.9 2 1 0 2 2 2 0 GRB2-binding adapter (GAPT) PH_16 PF17838.1 ETO21226.1 - 0.042 13.7 0.1 0.12 12.2 0.0 1.8 1 1 1 2 2 2 0 PH domain PH_4 PF15404.6 ETO21226.1 - 0.21 11.4 3.5 0.098 12.4 0.3 2.2 2 1 0 2 2 2 0 Pleckstrin homology domain PH_12 PF16457.5 ETO21226.1 - 0.93 10.0 5.9 0.37 11.3 0.2 2.7 2 1 0 2 2 2 0 Pleckstrin homology domain SASA PF03629.18 ETO21227.1 - 4.5e-48 163.9 0.0 1.2e-27 97.1 0.0 2.2 2 0 0 2 2 2 2 Carbohydrate esterase, sialic acid-specific acetylesterase PX PF00787.24 ETO21229.1 - 8.7e-12 45.0 0.1 1.4e-11 44.4 0.1 1.4 1 0 0 1 1 1 1 PX domain PHD PF00628.29 ETO21230.1 - 8.8e-05 22.3 3.1 0.00035 20.4 3.1 2.1 1 0 0 1 1 1 1 PHD-finger Peptidase_S49_N PF08496.10 ETO21230.1 - 2.1 8.4 13.3 0.043 13.9 1.8 3.4 3 0 0 3 3 3 0 Peptidase family S49 N-terminal DED PF01335.21 ETO21230.1 - 2.3 8.6 8.3 1.2 9.5 0.0 4.1 5 0 0 5 5 5 0 Death effector domain FYVE PF01363.21 ETO21231.1 - 5.8e-07 29.6 8.7 5.8e-07 29.6 8.7 1.9 1 1 0 1 1 1 1 FYVE zinc finger DUF3165 PF11364.8 ETO21232.1 - 0.12 12.7 0.5 7.3 7.0 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3165) Arrestin_N PF00339.29 ETO21234.1 - 0.066 13.3 0.2 0.31 11.1 0.0 2.1 2 0 0 2 2 2 0 Arrestin (or S-antigen), N-terminal domain Chlam_PMP PF02415.17 ETO21235.1 - 0.016 15.7 22.5 0.044 14.3 0.3 5.7 6 0 0 6 6 6 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF5123 PF17161.4 ETO21235.1 - 0.024 15.7 6.6 0.12 13.4 0.6 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF5123) Beta_helix PF13229.6 ETO21236.1 - 0.0029 17.5 1.2 0.0076 16.1 1.2 1.6 1 1 0 1 1 1 1 Right handed beta helix region Chlam_PMP PF02415.17 ETO21236.1 - 0.021 15.3 11.3 0.027 14.9 0.4 4.2 5 0 0 5 5 5 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF5433 PF17498.2 ETO21236.1 - 0.075 13.2 6.2 0.25 11.6 6.2 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5433) RDD PF06271.12 ETO21236.1 - 0.11 12.7 4.0 0.045 14.0 1.4 1.6 2 0 0 2 2 2 0 RDD family TMEM213 PF15192.6 ETO21236.1 - 0.14 12.2 0.4 0.26 11.3 0.4 1.5 1 0 0 1 1 1 0 TMEM213 family DUF3339 PF11820.8 ETO21236.1 - 0.15 12.3 0.1 0.15 12.3 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3339) DUF2207 PF09972.9 ETO21236.1 - 1.4 7.6 3.6 0.33 9.7 0.2 1.6 1 1 0 2 2 2 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 ETO21236.1 - 1.6 9.1 4.2 1.6 9.1 0.1 2.2 2 0 0 2 2 2 0 Orf78 (ac78) TMEM119 PF15724.5 ETO21236.1 - 2.1 8.3 4.5 9.7 6.2 0.2 2.1 2 0 0 2 2 2 0 TMEM119 family Ycf70 PF17382.2 ETO21236.1 - 9.2 6.7 6.8 3.9 7.9 0.1 2.5 2 0 0 2 2 2 0 Uncharacterized Ycf70-like DUF2678 PF10856.8 ETO21237.1 - 4.1 7.3 6.9 0.23 11.4 0.4 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2678) Guanylate_cyc PF00211.20 ETO21240.1 - 5.2e-17 62.1 0.0 6.7e-09 35.6 0.0 2.3 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 ETO21240.1 - 7.6e-11 42.7 0.4 2e-10 41.3 0.1 1.9 2 0 0 2 2 2 1 AAA ATPase domain PH PF00169.29 ETO21240.1 - 1.1e-05 25.9 0.9 1.1e-05 25.9 0.9 2.6 2 0 0 2 2 2 1 PH domain AAA_22 PF13401.6 ETO21240.1 - 0.00011 22.5 0.1 0.004 17.4 0.1 2.9 1 1 0 1 1 1 1 AAA domain AAA_14 PF13173.6 ETO21240.1 - 0.00012 22.1 0.1 1.8 8.6 0.0 3.7 3 0 0 3 3 3 1 AAA domain NB-ARC PF00931.22 ETO21240.1 - 0.027 13.7 0.1 0.067 12.4 0.1 1.6 1 0 0 1 1 1 0 NB-ARC domain ATPase_2 PF01637.18 ETO21240.1 - 0.03 14.3 0.1 0.2 11.5 0.1 2.4 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea DUF3523 PF12037.8 ETO21240.1 - 0.63 9.4 5.3 1.6 8.0 5.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3523) GvpL_GvpF PF06386.11 ETO21241.1 - 2 8.3 6.8 0.18 11.7 2.3 1.5 2 0 0 2 2 2 0 Gas vesicle synthesis protein GvpL/GvpF RhoGEF PF00621.20 ETO21242.1 - 5.3e-17 62.7 2.7 5.3e-17 62.7 2.7 1.8 2 1 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 ETO21242.1 - 3.1e-06 27.2 1.8 7.5e-06 26.0 1.8 1.6 1 0 0 1 1 1 1 FYVE zinc finger BAF1_ABF1 PF04684.13 ETO21242.1 - 0.0034 16.5 15.1 0.11 11.5 7.5 2.0 2 0 0 2 2 2 2 BAF1 / ABF1 chromatin reorganising factor UPF0239 PF06783.11 ETO21242.1 - 5.8 7.2 6.4 3.4 7.9 0.0 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) MID_MedPIWI PF18296.1 ETO21242.1 - 8.3 6.1 10.3 16 5.2 0.0 2.2 2 0 0 2 2 2 0 MID domain of medPIWI ARTD15_N PF18084.1 ETO21243.1 - 6.6 7.1 6.1 3.6 7.9 1.6 3.0 2 1 0 2 2 2 0 ARTD15 N-terminal domain ART PF01129.18 ETO21244.1 - 0.0084 15.4 0.1 0.015 14.6 0.1 1.4 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PUB PF09409.10 ETO21244.1 - 0.021 14.7 0.6 0.12 12.3 0.6 2.4 1 0 0 1 1 1 0 PUB domain CW_binding_1 PF01473.20 ETO21244.1 - 0.047 14.0 1.2 0.2 12.1 1.2 2.2 1 0 0 1 1 1 0 Putative cell wall binding repeat UFC1 PF08694.11 ETO21244.1 - 0.24 11.0 5.1 0.29 10.8 0.1 3.0 3 0 0 3 3 3 0 Ubiquitin-fold modifier-conjugating enzyme 1 Secretin_N_2 PF07655.13 ETO21245.1 - 0.023 15.2 12.7 0.023 15.2 12.7 4.3 4 2 0 4 4 4 0 Secretin N-terminal domain Pex2_Pex12 PF04757.14 ETO21245.1 - 0.028 14.0 7.7 0.065 12.8 0.4 2.3 2 0 0 2 2 2 0 Pex2 / Pex12 amino terminal region Spt20 PF12090.8 ETO21245.1 - 2.5 7.6 32.3 0.28 10.8 3.2 3.2 3 0 0 3 3 3 0 Spt20 family RPAP2_Rtr1 PF04181.13 ETO21246.1 - 7e-13 48.7 0.2 7e-13 48.7 0.2 2.5 2 1 0 2 2 2 1 Rtr1/RPAP2 family BSMAP PF12280.8 ETO21246.1 - 0.24 11.6 8.7 0.033 14.4 2.8 2.1 2 0 0 2 2 2 0 Brain specific membrane anchored protein CDC45 PF02724.14 ETO21246.1 - 2.3 6.4 14.3 4.1 5.6 14.3 1.3 1 0 0 1 1 1 0 CDC45-like protein RRM_1 PF00076.22 ETO21247.1 - 3.1e-17 62.1 0.0 4.6e-17 61.6 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO21247.1 - 0.00079 19.4 0.3 0.0017 18.3 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif OB_RNB PF08206.11 ETO21247.1 - 3.7 7.3 5.4 12 5.7 2.6 2.8 1 1 1 2 2 2 0 Ribonuclease B OB domain Menin PF05053.13 ETO21249.1 - 1.3 7.3 4.4 2 6.7 4.4 1.2 1 0 0 1 1 1 0 Menin EF-hand_7 PF13499.6 ETO21250.1 - 0.019 15.4 2.6 0.061 13.8 2.6 1.9 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO21250.1 - 0.031 14.2 1.7 4.6 7.4 0.1 2.5 2 0 0 2 2 2 0 EF-hand domain EF-hand_8 PF13833.6 ETO21250.1 - 0.31 10.9 3.0 7.1 6.6 1.2 2.4 1 1 1 2 2 2 0 EF-hand domain pair PA26 PF04636.13 ETO21250.1 - 3.4 6.5 7.5 3.8 6.3 7.5 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Mem_trans PF03547.18 ETO21250.1 - 9.7 4.5 5.9 11 4.2 5.9 1.3 1 0 0 1 1 1 0 Membrane transport protein RVT_1 PF00078.27 ETO21251.1 - 0.001 18.6 1.5 0.0019 17.7 0.3 1.8 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) LAGLIDADG_1 PF00961.19 ETO21251.1 - 2.4 9.1 8.8 8.4 7.4 1.9 2.4 1 1 1 2 2 2 0 LAGLIDADG endonuclease Rad10 PF03834.14 ETO21252.1 - 0.053 13.5 0.5 0.17 11.9 0.2 2.0 2 0 0 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Auxin_repressed PF05564.12 ETO21252.1 - 0.34 11.6 7.8 0.84 10.3 5.6 2.6 2 0 0 2 2 2 0 Dormancy/auxin associated protein DUF737 PF05300.11 ETO21253.1 - 0.53 10.6 9.1 0.96 9.8 9.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF737) WD40 PF00400.32 ETO21254.1 - 7e-11 42.5 1.8 0.0074 17.1 0.0 5.0 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21254.1 - 2.4e-09 37.3 0.1 5.5e-05 23.4 0.0 4.2 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain XK-related PF09815.9 ETO21254.1 - 0.00046 19.4 7.4 0.0009 18.4 7.4 1.5 1 0 0 1 1 1 1 XK-related protein PD40 PF07676.12 ETO21254.1 - 0.00064 19.6 0.0 0.11 12.5 0.0 2.6 2 0 0 2 2 2 1 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 ETO21254.1 - 0.0052 16.7 0.3 0.14 12.1 0.0 2.8 3 0 0 3 3 3 1 Transcription factor IIIC subunit delta N-term LRIF1 PF15741.5 ETO21254.1 - 0.062 11.8 11.4 0.014 14.0 8.4 1.4 2 0 0 2 2 2 0 Ligand-dependent nuclear receptor-interacting factor 1 DUF4407 PF14362.6 ETO21256.1 - 0.28 10.5 7.1 0.36 10.1 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 ETO21256.1 - 3.1 6.0 10.1 3.5 5.8 10.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Ank_4 PF13637.6 ETO21257.1 - 9.3e-36 121.8 8.7 8.4e-07 29.4 0.6 6.3 5 1 1 6 6 6 6 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO21257.1 - 7.4e-35 119.4 15.6 4.1e-10 40.1 0.1 5.0 1 1 5 6 6 6 6 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO21257.1 - 2.7e-21 75.3 4.2 0.0001 22.5 0.1 6.4 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21257.1 - 9.3e-21 71.7 12.4 0.0074 16.7 0.0 9.6 9 2 1 10 10 10 5 Ankyrin repeat Ank PF00023.30 ETO21257.1 - 8.7e-19 67.1 5.9 0.0026 18.1 0.5 8.1 9 0 0 9 9 9 5 Ankyrin repeat SHP PF03579.13 ETO21257.1 - 0.1 12.6 2.7 0.23 11.5 2.7 1.5 1 0 0 1 1 1 0 Small hydrophobic protein InvH PF04741.12 ETO21258.1 - 2.2 8.2 11.9 0.23 11.4 4.3 2.4 2 0 0 2 2 2 0 InvH outer membrane lipoprotein PIG-U PF06728.13 ETO21259.1 - 5.4e-11 42.2 0.1 5.7e-11 42.1 0.1 1.0 1 0 0 1 1 1 1 GPI transamidase subunit PIG-U S-methyl_trans PF02574.16 ETO21260.1 - 2.5e-16 60.3 0.0 2.9e-16 60.1 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase ENTH PF01417.20 ETO21261.1 - 0.00096 19.2 0.3 0.002 18.2 0.3 1.6 1 0 0 1 1 1 1 ENTH domain PIP5K PF01504.18 ETO21262.1 - 2.7e-71 240.0 1.1 3.6e-71 239.6 1.1 1.1 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Kelch_4 PF13418.6 ETO21263.1 - 3.3e-05 23.8 0.5 0.019 15.0 0.0 3.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO21263.1 - 3.4e-05 24.0 1.7 2 8.8 0.1 3.8 2 1 1 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ETO21263.1 - 0.00028 20.7 3.2 0.11 12.5 0.1 4.5 5 1 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO21263.1 - 0.00085 18.9 2.3 0.054 13.1 0.2 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO21263.1 - 0.0016 18.4 6.3 0.19 11.7 0.7 4.5 5 0 0 5 5 5 1 Kelch motif Pkinase PF00069.25 ETO21266.1 - 1.8e-34 119.3 0.1 2.3e-34 119.0 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21266.1 - 5.5e-08 32.4 0.2 1.1e-07 31.5 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ETO21266.1 - 0.0015 18.5 0.1 0.0043 17.0 0.1 1.7 2 1 0 2 2 2 1 Phosphotransferase enzyme family Choline_kinase PF01633.20 ETO21266.1 - 0.014 15.0 0.1 0.033 13.8 0.0 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase V-ATPase_H_N PF03224.14 ETO21266.1 - 0.023 14.0 0.1 0.032 13.5 0.1 1.1 1 0 0 1 1 1 0 V-ATPase subunit H Pkinase_Tyr PF07714.17 ETO21267.1 - 1e-57 195.4 0.0 3.4e-51 174.0 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO21267.1 - 8.4e-38 130.2 0.0 4.2e-37 128.0 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO21267.1 - 3.9e-05 22.6 2.0 0.00012 21.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO21267.1 - 0.029 13.7 0.1 0.057 12.8 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family V_ATPase_I PF01496.19 ETO21268.1 - 2.3e-221 737.0 10.4 2.9e-221 736.7 10.4 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF1363 PF07101.11 ETO21268.1 - 0.033 14.5 0.1 0.55 10.5 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1363) Pkinase PF00069.25 ETO21271.1 - 7.5e-06 25.5 0.0 9.8e-06 25.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain CENP-B_dimeris PF09026.10 ETO21273.1 - 0.2 12.1 25.2 5.7 7.4 4.8 3.2 3 0 0 3 3 3 0 Centromere protein B dimerisation domain Presenilin PF01080.17 ETO21273.1 - 3.3 6.4 6.9 4.6 5.9 6.9 1.2 1 0 0 1 1 1 0 Presenilin HAP1_N PF04849.13 ETO21274.1 - 0.00058 19.2 9.2 0.00084 18.6 9.2 1.3 1 0 0 1 1 1 1 HAP1 N-terminal conserved region UPF0242 PF06785.11 ETO21274.1 - 0.0043 17.2 11.2 0.0043 17.2 11.2 1.7 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus bZIP_1 PF00170.21 ETO21274.1 - 0.0094 16.0 4.2 0.0094 16.0 4.2 3.4 3 1 1 4 4 3 1 bZIP transcription factor HMMR_N PF15905.5 ETO21274.1 - 0.0094 15.5 14.0 0.0094 15.5 14.0 1.8 2 0 0 2 2 2 1 Hyaluronan mediated motility receptor N-terminal Macoilin PF09726.9 ETO21274.1 - 0.011 14.3 13.7 0.015 13.9 13.7 1.2 1 0 0 1 1 1 0 Macoilin family TSC22 PF01166.18 ETO21274.1 - 0.013 15.8 2.0 0.013 15.8 2.0 2.4 1 1 0 2 2 2 0 TSC-22/dip/bun family DivIC PF04977.15 ETO21274.1 - 0.027 14.3 2.0 0.027 14.3 2.0 2.9 2 1 1 3 3 2 0 Septum formation initiator Cnn_1N PF07989.11 ETO21274.1 - 0.033 14.3 11.7 0.033 14.3 11.7 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 Golgin_A5 PF09787.9 ETO21274.1 - 0.056 12.9 13.1 0.012 15.1 9.1 1.8 2 0 0 2 2 2 0 Golgin subfamily A member 5 SKA2 PF16740.5 ETO21274.1 - 0.067 13.0 11.3 0.15 11.8 11.3 1.7 1 1 0 1 1 1 0 Spindle and kinetochore-associated protein 2 DUF812 PF05667.11 ETO21274.1 - 0.14 11.0 18.5 0.18 10.6 18.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF812) Lectin_N PF03954.14 ETO21274.1 - 0.2 11.4 6.2 0.38 10.5 5.4 1.7 1 1 0 1 1 1 0 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 ETO21274.1 - 0.34 11.0 6.8 0.72 9.9 6.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Herpes_BLRF2 PF05812.12 ETO21274.1 - 0.48 10.6 9.3 0.26 11.4 6.1 2.1 2 0 0 2 2 2 0 Herpesvirus BLRF2 protein AAA_24 PF13479.6 ETO21274.1 - 0.54 10.0 5.1 0.11 12.3 1.4 1.7 2 0 0 2 2 2 0 AAA domain DUF4407 PF14362.6 ETO21274.1 - 0.64 9.3 8.2 0.056 12.8 4.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Jnk-SapK_ap_N PF09744.9 ETO21274.1 - 3.5 7.8 21.6 2.9 8.1 17.1 2.5 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 ABC_tran_CTD PF16326.5 ETO21274.1 - 4.7 7.5 15.7 1.9 8.8 10.4 2.6 1 1 1 2 2 2 0 ABC transporter C-terminal domain FlaC_arch PF05377.11 ETO21274.1 - 6.9 7.2 16.5 0.64 10.5 2.1 3.0 2 1 1 3 3 2 0 Flagella accessory protein C (FlaC) ADIP PF11559.8 ETO21274.1 - 8 6.5 22.9 1.2 9.2 6.0 2.8 2 1 1 3 3 3 0 Afadin- and alpha -actinin-Binding DUF5595 PF18077.1 ETO21274.1 - 8.5 6.5 12.7 1.8 8.7 2.1 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5595) YabA PF06156.13 ETO21274.1 - 9.5 6.9 17.4 70 4.1 12.1 3.1 2 1 0 2 2 2 0 Initiation control protein YabA VWA_2 PF13519.6 ETO21275.1 - 0.0045 17.6 0.0 0.0085 16.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain Polysacc_deac_1 PF01522.21 ETO21275.1 - 0.11 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Polysaccharide deacetylase SecA_DEAD PF07517.14 ETO21276.1 - 1.6e-07 30.9 0.0 1.6e-07 30.9 0.0 4.8 3 1 0 3 3 2 1 SecA DEAD-like domain RsgA_GTPase PF03193.16 ETO21276.1 - 1.7e-05 24.8 1.4 0.00024 21.1 0.1 3.7 2 1 0 2 2 2 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO21276.1 - 3e-05 24.1 0.1 0.00026 21.0 0.1 2.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO21276.1 - 0.0018 18.8 0.0 0.0018 18.8 0.0 5.3 6 0 0 6 6 5 1 ABC transporter P-mevalo_kinase PF04275.14 ETO21276.1 - 0.0032 17.4 0.3 0.0032 17.4 0.3 4.0 3 0 0 3 3 3 1 Phosphomevalonate kinase AAA_29 PF13555.6 ETO21276.1 - 0.02 14.6 0.2 0.13 12.1 0.0 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_19 PF13245.6 ETO21276.1 - 0.023 15.0 1.1 0.21 11.9 0.0 3.4 2 0 0 2 2 2 0 AAA domain TetR PF13972.6 ETO21276.1 - 0.03 14.0 2.4 0.12 12.0 0.2 3.3 2 0 0 2 2 2 0 Bacterial transcriptional repressor FtsK_SpoIIIE PF01580.18 ETO21276.1 - 1.3 8.3 4.2 2.2 7.6 0.0 3.4 4 0 0 4 4 4 0 FtsK/SpoIIIE family Usp PF00582.26 ETO21276.1 - 1.3 9.5 7.7 0.042 14.4 0.4 2.3 2 0 0 2 2 1 0 Universal stress protein family AAA PF00004.29 ETO21276.1 - 1.4 9.4 17.9 22 5.5 0.0 6.3 6 0 0 6 6 5 0 ATPase family associated with various cellular activities (AAA) Mating_N PF12731.7 ETO21276.1 - 1.8 8.7 5.4 3 8.0 0.0 4.3 4 0 0 4 4 3 0 Mating-type protein beta 1 ApoO PF09769.9 ETO21276.1 - 5.2 7.0 10.5 9 6.3 0.4 4.8 4 0 0 4 4 4 0 Apolipoprotein O FpoO PF10621.9 ETO21276.1 - 9.9 6.5 6.4 5.5 7.4 3.3 2.2 2 0 0 2 2 1 0 F420H2 dehydrogenase subunit FpoO Pkinase PF00069.25 ETO21277.1 - 2.5e-12 46.7 4.2 2.6e-07 30.3 0.0 4.3 4 0 0 4 4 4 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21277.1 - 5.3e-07 29.2 0.0 0.00097 18.5 0.0 3.0 3 1 0 3 3 3 2 Protein tyrosine kinase UPF0565 PF10561.9 ETO21277.1 - 1.5 7.9 23.4 1.9 7.6 11.6 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0565 DUF2052 PF09747.9 ETO21277.1 - 4.1 7.5 20.0 9.6 6.3 16.9 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Toluene_X PF03349.16 ETO21278.1 - 0.016 13.8 0.1 0.02 13.5 0.1 1.1 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) Peptidase_M41 PF01434.18 ETO21279.1 - 3.1e-39 134.8 0.1 3.1e-39 134.8 0.1 1.8 2 0 0 2 2 2 1 Peptidase family M41 Spt20 PF12090.8 ETO21279.1 - 0.01 15.5 11.7 0.012 15.2 11.7 1.3 1 0 0 1 1 1 0 Spt20 family DDHD PF02862.17 ETO21279.1 - 0.24 11.5 6.7 0.29 11.3 6.7 1.2 1 0 0 1 1 1 0 DDHD domain BROMI PF14961.6 ETO21279.1 - 0.27 8.6 7.0 0.31 8.4 7.0 1.1 1 0 0 1 1 1 0 Broad-minded protein Neur_chan_memb PF02932.16 ETO21279.1 - 1.4 9.0 3.9 1.5 8.8 3.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Roughex PF06020.11 ETO21279.1 - 3.3 6.7 14.7 4.3 6.3 14.7 1.2 1 0 0 1 1 1 0 Drosophila roughex protein VPS13 PF16908.5 ETO21280.1 - 0.071 12.9 0.0 0.087 12.6 0.0 1.4 1 1 0 1 1 1 0 Vacuolar sorting-associated protein 13, N-terminal LacI PF00356.21 ETO21280.1 - 0.078 12.8 0.2 0.21 11.4 0.2 1.7 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family B2-adapt-app_C PF09066.10 ETO21281.1 - 1.7e-09 37.7 0.1 3.4e-09 36.8 0.0 1.5 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain Pkinase PF00069.25 ETO21282.1 - 1.3e-08 34.6 0.2 0.0013 18.1 0.0 2.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21282.1 - 0.00017 21.0 0.7 0.17 11.2 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Hus1 PF04005.12 ETO21283.1 - 1.1e-26 93.6 4.7 1.1e-26 93.6 4.7 3.1 2 1 0 2 2 2 1 Hus1-like protein DUF2682 PF10909.8 ETO21283.1 - 0.049 14.1 1.7 0.28 11.7 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2682) DUF809 PF05663.11 ETO21283.1 - 0.12 12.5 1.4 0.62 10.2 0.5 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF809) adh_short PF00106.25 ETO21285.1 - 1.4e-18 67.0 0.1 1.9e-18 66.6 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO21285.1 - 8.6e-12 45.1 0.0 1e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO21285.1 - 1.7e-07 31.4 0.1 2.4e-07 30.9 0.1 1.2 1 0 0 1 1 1 1 KR domain CENP-M PF11111.8 ETO21285.1 - 0.055 12.7 0.1 1.5 8.0 0.1 2.2 1 1 0 2 2 2 0 Centromere protein M (CENP-M) RGS PF00615.19 ETO21286.1 - 0.0029 17.9 0.3 0.006 16.8 0.3 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain Retrotran_gag_2 PF14223.6 ETO21286.1 - 0.043 13.5 0.1 0.72 9.5 0.0 2.3 2 0 0 2 2 2 0 gag-polypeptide of LTR copia-type DUF4042 PF13251.6 ETO21287.1 - 1.7e-07 31.1 4.4 4.1e-06 26.6 0.0 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4042) HEAT PF02985.22 ETO21287.1 - 0.068 13.5 0.6 1.4 9.4 0.0 3.4 4 0 0 4 4 4 0 HEAT repeat RCC1 PF00415.18 ETO21288.1 - 8.7e-08 32.7 0.0 0.0036 17.9 0.0 2.3 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat DUF4999 PF16390.5 ETO21288.1 - 0.078 13.2 0.1 0.27 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function RCC1_2 PF13540.6 ETO21288.1 - 0.73 9.7 3.6 19 5.2 0.1 3.2 3 0 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO21289.1 - 2.3e-21 76.2 6.1 3.7e-12 46.7 0.2 3.5 3 1 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO21289.1 - 1.5e-20 72.5 6.6 4e-10 39.2 0.8 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat Ras PF00071.22 ETO21290.1 - 2.1e-19 69.7 1.2 3.4e-19 69.0 1.2 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO21290.1 - 5e-10 39.6 0.8 1.1e-09 38.6 0.5 1.7 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO21290.1 - 0.0055 16.2 0.9 0.0086 15.5 0.7 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family RRM_1 PF00076.22 ETO21291.1 - 0.00013 21.7 0.0 0.00032 20.5 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pim PF16765.5 ETO21292.1 - 0.012 15.7 0.2 0.033 14.3 0.2 1.7 1 0 0 1 1 1 0 Pesticin immunity protein Pneumo_NS1 PF03438.13 ETO21292.1 - 0.016 15.3 0.7 1.7 8.8 0.0 2.5 2 0 0 2 2 2 0 Pneumovirus NS1 protein DnaJ PF00226.31 ETO21293.1 - 3e-19 68.9 0.8 4.2e-19 68.4 0.8 1.2 1 0 0 1 1 1 1 DnaJ domain Rotamase_2 PF13145.6 ETO21293.1 - 0.0055 17.5 2.5 0.0066 17.3 2.5 1.1 1 0 0 1 1 1 1 PPIC-type PPIASE domain AhpC-TSA PF00578.21 ETO21293.1 - 0.052 13.5 0.1 0.06 13.3 0.1 1.3 1 0 0 1 1 1 0 AhpC/TSA family Fe-ADH PF00465.19 ETO21294.1 - 0.008 15.0 0.0 0.0095 14.8 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH PF00465.19 ETO21295.1 - 4.4e-21 75.1 0.0 4.9e-21 75.0 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ETO21295.1 - 5.4e-09 36.1 0.0 6.3e-09 35.9 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase G-alpha PF00503.20 ETO21297.1 - 3.4e-18 65.9 1.6 3.8e-18 65.8 1.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit YqzE PF14038.6 ETO21298.1 - 0.5 10.4 8.1 0.79 9.8 8.1 1.2 1 0 0 1 1 1 0 YqzE-like protein CENP-B_dimeris PF09026.10 ETO21299.1 - 0.056 13.8 7.5 0.092 13.1 7.5 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Orf78 PF06024.12 ETO21299.1 - 2.1 8.7 4.7 4.6 7.6 0.0 2.2 2 0 0 2 2 2 0 Orf78 (ac78) Ion_trans PF00520.31 ETO21300.1 - 4.5e-10 39.2 2.9 7.2e-10 38.5 2.9 1.2 1 0 0 1 1 1 1 Ion transport protein Mucin PF01456.17 ETO21300.1 - 0.03 14.3 19.9 0.15 12.0 2.4 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein RIC3 PF15361.6 ETO21300.1 - 0.034 14.6 0.5 0.034 14.6 0.5 3.7 3 1 0 3 3 3 0 Resistance to inhibitors of cholinesterase homologue 3 TMEMspv1-c74-12 PF11044.8 ETO21300.1 - 0.39 10.7 2.8 1.7 8.7 2.8 2.1 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein PPR_3 PF13812.6 ETO21301.1 - 1e-07 31.9 3.2 6.5e-07 29.3 1.6 2.6 2 0 0 2 2 2 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO21301.1 - 2.9e-07 30.6 9.2 5.8e-07 29.6 1.9 3.1 3 0 0 3 3 3 1 PPR repeat family PPR_long PF17177.4 ETO21301.1 - 0.0059 16.0 0.1 0.041 13.2 0.1 2.2 2 0 0 2 2 2 1 Pentacotripeptide-repeat region of PRORP PPR PF01535.20 ETO21301.1 - 0.013 15.7 0.7 0.013 15.7 0.7 3.9 5 0 0 5 5 5 0 PPR repeat PPR_1 PF12854.7 ETO21301.1 - 0.048 13.4 0.6 4.5 7.1 0.0 2.9 2 0 0 2 2 2 0 PPR repeat FixP_N PF14715.6 ETO21301.1 - 0.1 12.4 0.0 0.21 11.4 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Ribonuc_red_lgN PF00317.21 ETO21301.1 - 0.22 11.5 2.8 8 6.6 3.0 3.0 1 1 1 2 2 2 0 Ribonucleotide reductase, all-alpha domain ANAPC3 PF12895.7 ETO21301.1 - 0.49 10.7 4.5 0.44 10.8 1.0 2.6 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SIR4_SID PF16991.5 ETO21302.1 - 2.3 8.3 13.4 5 7.2 4.6 2.1 2 0 0 2 2 2 0 Sir4 SID domain TPR_1 PF00515.28 ETO21303.1 - 3.5e-14 51.9 8.1 5.7e-08 32.3 1.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21303.1 - 6.3e-12 44.6 4.0 1.5e-05 24.7 0.4 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO21303.1 - 8e-08 31.8 2.2 9.1e-08 31.7 0.9 1.8 2 0 0 2 2 2 1 TPR repeat TPR_MalT PF17874.1 ETO21303.1 - 1.8e-05 24.3 0.7 2.4e-05 23.9 0.1 1.5 2 0 0 2 2 2 1 MalT-like TPR region TPR_12 PF13424.6 ETO21303.1 - 1.9e-05 24.8 1.9 0.041 14.2 0.1 2.9 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21303.1 - 0.00013 21.9 3.6 0.09 13.0 0.1 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO21303.1 - 0.0025 18.3 0.7 0.17 12.4 0.2 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO21303.1 - 0.02 15.1 4.2 0.27 11.5 1.0 2.5 1 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ETO21303.1 - 0.032 14.6 0.6 0.032 14.6 0.6 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SNAP PF14938.6 ETO21303.1 - 0.063 12.7 2.9 0.62 9.4 2.9 2.2 1 1 0 1 1 1 0 Soluble NSF attachment protein, SNAP TPR_10 PF13374.6 ETO21303.1 - 0.071 13.0 1.8 2 8.4 0.0 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO21303.1 - 0.12 13.2 0.1 2.7 9.1 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat DUF1722 PF08349.11 ETO21304.1 - 0.064 13.5 0.7 4.5 7.6 0.1 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1722) Pox_Ag35 PF03286.14 ETO21306.1 - 0.019 14.8 7.9 0.022 14.6 7.9 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Tim54 PF11711.8 ETO21306.1 - 0.04 12.7 5.4 0.044 12.6 5.4 1.0 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2457 PF10446.9 ETO21306.1 - 0.11 11.7 18.5 0.11 11.7 18.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Afi1 PF07792.12 ETO21306.1 - 0.31 11.5 8.9 0.35 11.3 8.9 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM76 PF16046.5 ETO21306.1 - 0.54 9.6 5.1 0.64 9.3 5.1 1.0 1 0 0 1 1 1 0 FAM76 protein FAM60A PF15396.6 ETO21306.1 - 0.59 10.1 5.5 0.69 9.9 5.5 1.1 1 0 0 1 1 1 0 Protein Family FAM60A NPR3 PF03666.13 ETO21306.1 - 0.69 8.6 9.9 0.77 8.5 9.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CPSF100_C PF13299.6 ETO21306.1 - 0.85 9.8 5.8 0.98 9.6 5.8 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 ETO21306.1 - 1 7.4 17.7 1.1 7.3 17.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi MRNIP PF15749.5 ETO21306.1 - 1.2 9.9 12.6 1.7 9.4 12.6 1.2 1 0 0 1 1 1 0 MRN-interacting protein Nop14 PF04147.12 ETO21306.1 - 1.5 6.9 18.1 1.7 6.8 18.1 1.0 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 ETO21306.1 - 2.1 8.8 15.1 8 6.9 15.1 1.9 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TFIIE-A_C PF11521.8 ETO21306.1 - 3.6 8.0 20.6 3 8.2 1.4 2.1 1 1 1 2 2 2 0 C-terminal general transcription factor TFIIE alpha TRAP_alpha PF03896.16 ETO21306.1 - 3.7 6.7 8.0 4 6.6 8.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF913 PF06025.12 ETO21306.1 - 4.3 6.2 7.8 4.9 6.0 7.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO21306.1 - 5.6 6.1 7.8 5.8 6.0 7.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETO21306.1 - 5.7 6.2 20.8 7.2 5.8 20.8 1.1 1 0 0 1 1 1 0 NOA36 protein CDC45 PF02724.14 ETO21306.1 - 6.1 5.0 14.1 6.2 5.0 14.1 1.0 1 0 0 1 1 1 0 CDC45-like protein UPF0560 PF10577.9 ETO21306.1 - 7.7 4.9 12.6 8.5 4.7 12.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 DUF4637 PF15470.6 ETO21306.1 - 8.1 6.1 12.7 11 5.8 12.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Presenilin PF01080.17 ETO21306.1 - 9.6 4.9 8.8 11 4.7 8.8 1.0 1 0 0 1 1 1 0 Presenilin RRN3 PF05327.11 ETO21306.1 - 9.7 4.6 10.7 10 4.6 10.7 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 COX7B PF05392.11 ETO21308.1 - 4.1 7.1 5.2 2.1 8.1 2.2 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB RGS PF00615.19 ETO21309.1 - 9e-11 42.1 0.1 1.3e-10 41.6 0.1 1.2 1 0 0 1 1 1 1 Regulator of G protein signaling domain SelP_N PF04592.14 ETO21310.1 - 0.0042 16.5 2.6 0.0057 16.1 2.6 1.2 1 0 0 1 1 1 1 Selenoprotein P, N terminal region Spc24 PF08286.11 ETO21310.1 - 0.058 13.6 0.1 0.074 13.3 0.1 1.2 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 Macoilin PF09726.9 ETO21310.1 - 0.64 8.5 3.8 0.7 8.4 3.8 1.0 1 0 0 1 1 1 0 Macoilin family DUF1765 PF08578.10 ETO21312.1 - 0.033 14.7 0.2 3.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1765) eRF1_2 PF03464.15 ETO21313.1 - 5.8e-25 88.1 1.4 3e-24 85.8 1.4 2.0 1 1 0 1 1 1 1 eRF1 domain 2 eRF1_3 PF03465.15 ETO21313.1 - 5.6e-18 65.5 0.1 1.6e-17 64.0 0.1 1.8 1 0 0 1 1 1 1 eRF1 domain 3 BPL_N PF09825.9 ETO21313.1 - 0.087 11.9 1.1 0.22 10.6 1.1 1.6 1 1 0 1 1 1 0 Biotin-protein ligase, N terminal Pkinase PF00069.25 ETO21314.1 - 4.3e-61 206.6 0.2 5.3e-61 206.3 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21314.1 - 3.8e-42 144.4 0.1 4.6e-42 144.1 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO21314.1 - 8.4e-08 31.9 0.0 1.2e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO21314.1 - 4.6e-05 22.9 0.5 4.6e-05 22.9 0.5 1.6 2 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO21314.1 - 0.00045 20.2 0.0 0.00055 19.9 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO21314.1 - 0.0014 17.7 0.1 0.0018 17.3 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ETO21314.1 - 0.013 15.1 0.0 0.018 14.7 0.0 1.1 1 0 0 1 1 1 0 RIO1 family Choline_kinase PF01633.20 ETO21314.1 - 0.05 13.2 0.0 0.062 12.9 0.0 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Seadorna_VP7 PF07387.11 ETO21314.1 - 0.11 11.5 0.0 0.23 10.5 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 AI-2E_transport PF01594.16 ETO21315.1 - 4.7e-33 114.7 14.4 4.7e-33 114.7 14.4 1.4 2 0 0 2 2 2 1 AI-2E family transporter DUF2312 PF10073.9 ETO21315.1 - 8.2e-30 102.3 6.1 1.5e-29 101.5 6.1 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2312) DUF1269 PF06897.12 ETO21315.1 - 6.1 7.2 6.6 1.3 9.3 0.6 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1269) RCC1_2 PF13540.6 ETO21316.1 - 1.2e-08 34.5 1.0 2.7e-07 30.2 0.1 2.7 3 0 0 3 3 3 1 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO21316.1 - 2.4e-08 34.5 4.4 0.0025 18.4 0.8 3.7 3 2 0 3 3 3 3 Regulator of chromosome condensation (RCC1) repeat PGA2 PF07543.12 ETO21317.1 - 0.22 11.5 8.2 0.58 10.1 8.2 1.7 1 1 0 1 1 1 0 Protein trafficking PGA2 Ycf70 PF17382.2 ETO21318.1 - 0.74 10.3 5.1 0.5 10.8 2.2 2.2 2 1 1 3 3 3 0 Uncharacterized Ycf70-like Ank_2 PF12796.7 ETO21319.1 - 1.7e-15 57.4 4.7 5.6e-11 42.9 0.9 3.7 3 1 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO21319.1 - 6.2e-11 42.6 6.0 3.2e-07 30.8 0.2 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21319.1 - 3.7e-10 39.2 7.2 0.00045 20.4 0.0 5.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ETO21319.1 - 7.1e-08 32.6 2.6 0.0021 18.3 0.4 4.8 3 1 2 5 5 5 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO21319.1 - 2.4e-07 30.9 2.5 0.0028 18.0 0.0 3.7 4 0 0 4 4 3 2 Ankyrin repeat EVI2A PF05399.11 ETO21319.1 - 0.00054 19.6 12.2 0.00054 19.6 12.2 2.1 2 0 0 2 2 2 1 Ectropic viral integration site 2A protein (EVI2A) DUF4611 PF15387.6 ETO21319.1 - 0.0026 18.0 1.8 0.0026 18.0 1.8 3.1 2 1 1 3 3 2 1 Domain of unknown function (DUF4611) DNA_pol_phi PF04931.13 ETO21319.1 - 0.19 9.8 22.9 0.11 10.6 0.2 2.2 2 0 0 2 2 2 0 DNA polymerase phi ALMT PF11744.8 ETO21319.1 - 0.6 8.9 11.7 0.046 12.5 2.2 2.2 2 0 0 2 2 2 0 Aluminium activated malate transporter CDC45 PF02724.14 ETO21319.1 - 4.1 5.6 27.6 0.39 8.9 16.6 2.2 2 0 0 2 2 2 0 CDC45-like protein Gti1_Pac2 PF09729.9 ETO21319.1 - 6.9 6.7 21.3 6.3 6.8 12.0 2.5 2 0 0 2 2 2 0 Gti1/Pac2 family SLC12 PF03522.15 ETO21319.1 - 7.9 5.4 21.1 8.4 5.3 1.3 2.3 2 0 0 2 2 2 0 Solute carrier family 12 rRNA_proc-arch PF13234.6 ETO21320.1 - 1.4e-45 156.3 0.3 3.1e-45 155.2 0.3 1.6 1 0 0 1 1 1 1 rRNA-processing arch domain DSHCT PF08148.12 ETO21320.1 - 3.1e-42 144.0 2.3 4.3e-42 143.6 0.5 2.2 2 0 0 2 2 2 1 DSHCT (NUC185) domain Helicase_C PF00271.31 ETO21320.1 - 1.9e-08 34.6 0.5 7.7e-08 32.7 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Tic22 PF04278.12 ETO21320.1 - 0.14 11.6 1.8 0.18 11.2 0.7 1.7 2 0 0 2 2 2 0 Tic22-like family NPV_P10 PF05531.12 ETO21320.1 - 0.35 11.4 3.8 9.8 6.7 0.5 3.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DivIC PF04977.15 ETO21320.1 - 1.8 8.4 4.7 5.2 6.9 0.6 3.3 3 0 0 3 3 3 0 Septum formation initiator Efg1 PF10153.9 ETO21320.1 - 6.2 7.2 7.5 1.2 9.5 3.4 1.9 2 0 0 2 2 2 0 rRNA-processing protein Efg1 DUF1336 PF07059.12 ETO21321.1 - 8.5e-24 84.9 2.1 2.5e-14 53.9 0.1 3.2 1 1 0 2 2 2 2 Protein of unknown function (DUF1336) TRAM_LAG1_CLN8 PF03798.16 ETO21322.1 - 1.4e-23 83.7 33.1 2e-23 83.2 33.1 1.3 1 0 0 1 1 1 1 TLC domain NACHT PF05729.12 ETO21323.1 - 1.6e-14 54.2 0.0 5.6e-14 52.4 0.0 2.1 1 0 0 1 1 1 1 NACHT domain HEAT PF02985.22 ETO21323.1 - 3.3e-08 33.1 0.6 17 6.0 0.0 8.7 10 0 0 10 10 9 0 HEAT repeat NB-ARC PF00931.22 ETO21323.1 - 0.00041 19.6 7.3 0.0033 16.7 0.4 4.0 3 0 0 3 3 3 1 NB-ARC domain Ank_3 PF13606.6 ETO21323.1 - 0.00071 19.8 0.0 0.0091 16.4 0.0 3.1 1 0 0 1 1 1 1 Ankyrin repeat Ank PF00023.30 ETO21323.1 - 0.0024 18.2 0.0 0.015 15.7 0.0 2.5 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO21323.1 - 0.0057 16.9 0.0 0.016 15.6 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) HEAT_EZ PF13513.6 ETO21323.1 - 0.0071 16.8 0.0 14 6.3 0.0 5.0 6 0 0 6 6 6 1 HEAT-like repeat AAA_16 PF13191.6 ETO21323.1 - 0.032 14.6 0.0 0.097 13.0 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ETO21323.1 - 0.036 13.5 0.0 0.1 11.9 0.0 1.7 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ank_2 PF12796.7 ETO21323.1 - 0.097 13.3 2.9 0.62 10.7 0.0 3.9 4 0 0 4 4 4 0 Ankyrin repeats (3 copies) LisH_TPL PF17814.1 ETO21323.1 - 0.38 10.4 2.7 0.38 10.4 0.2 2.4 2 0 0 2 2 2 0 LisH-like dimerisation domain DUF87 PF01935.17 ETO21323.1 - 0.48 10.5 0.0 0.48 10.5 0.0 4.6 3 1 2 5 5 5 0 Helicase HerA, central domain AAA_22 PF13401.6 ETO21323.1 - 0.53 10.6 5.5 0.55 10.5 0.1 3.6 3 1 0 3 3 2 0 AAA domain FYVE PF01363.21 ETO21324.1 - 1.7e-09 37.7 8.0 3.4e-09 36.7 8.0 1.5 1 0 0 1 1 1 1 FYVE zinc finger A2L_zn_ribbon PF08792.10 ETO21324.1 - 0.023 14.4 6.0 0.11 12.3 0.4 2.5 2 0 0 2 2 2 0 A2L zinc ribbon domain zf-B_box PF00643.24 ETO21324.1 - 0.073 13.2 2.2 0.073 13.2 2.2 2.2 2 0 0 2 2 2 0 B-box zinc finger CDC45 PF02724.14 ETO21324.1 - 0.094 11.0 3.6 0.099 10.9 3.6 1.0 1 0 0 1 1 1 0 CDC45-like protein CCDC53 PF10152.9 ETO21324.1 - 0.11 12.9 2.5 0.13 12.6 2.5 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex VAD1-2 PF15310.6 ETO21324.1 - 0.3 10.9 7.9 0.12 12.2 5.7 1.4 2 0 0 2 2 2 0 Vitamin A-deficiency (VAD) rat model signalling IBR PF01485.21 ETO21324.1 - 0.32 11.3 12.3 0.07 13.4 6.4 2.3 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-RING_4 PF14570.6 ETO21324.1 - 0.91 9.4 9.8 1.1 9.1 8.8 1.7 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Presenilin PF01080.17 ETO21324.1 - 1.7 7.3 4.2 1.9 7.2 4.2 1.1 1 0 0 1 1 1 0 Presenilin Zn-ribbon_8 PF09723.10 ETO21324.1 - 2 8.6 8.5 22 5.3 8.5 2.5 1 1 0 1 1 1 0 Zinc ribbon domain CobT PF06213.12 ETO21324.1 - 3.9 6.8 11.4 4.6 6.5 11.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Spc7 PF08317.11 ETO21326.1 - 0.0061 15.5 2.3 0.0061 15.5 2.3 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein HAUS-augmin3 PF14932.6 ETO21326.1 - 0.49 9.9 37.1 0.074 12.6 14.9 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF2358 PF10184.9 ETO21326.1 - 0.88 9.9 6.9 0.77 10.1 0.2 3.0 1 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2358) RseA_C PF03873.13 ETO21326.1 - 6.6 7.0 10.4 29 5.0 10.4 2.2 1 1 0 1 1 1 0 Anti sigma-E protein RseA, C-terminal domain Guanylate_cyc PF00211.20 ETO21327.1 - 3.3e-26 92.0 4.1 6.3e-26 91.1 4.1 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain MutS_III PF05192.18 ETO21328.1 - 1.2e-15 58.2 2.5 1.2e-15 58.2 2.5 1.9 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ETO21328.1 - 0.00012 22.4 0.1 0.0011 19.2 0.1 2.5 1 1 0 1 1 1 1 MutS domain II DUF2451 PF10474.9 ETO21329.1 - 3.6e-32 112.0 0.2 4.4e-32 111.7 0.2 1.1 1 0 0 1 1 1 1 Protein of unknown function C-terminus (DUF2451) DUF3510 PF12022.8 ETO21329.1 - 0.0043 17.4 0.2 0.0092 16.4 0.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF3510) Sulfate_transp PF00916.20 ETO21330.1 - 1.8e-37 129.0 8.4 1.8e-37 129.0 8.4 2.2 1 1 1 2 2 2 1 Sulfate permease family STAS PF01740.21 ETO21330.1 - 9.1e-10 38.2 0.0 1.5e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 STAS domain YIEGIA PF14045.6 ETO21330.1 - 0.15 10.8 1.5 3.9 6.2 0.1 2.3 2 0 0 2 2 2 0 YIEGIA protein MFS_MOT1 PF16983.5 ETO21330.1 - 2.9 8.3 15.7 0.11 12.9 4.7 3.2 2 2 1 3 3 3 0 Molybdate transporter of MFS superfamily DUF4131 PF13567.6 ETO21330.1 - 6.2 6.4 7.8 1.6 8.4 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) MxiM PF11441.8 ETO21334.1 - 0.06 13.6 1.3 0.071 13.4 0.2 1.6 2 0 0 2 2 2 0 Pilot protein MxiM DUF3671 PF12420.8 ETO21334.1 - 0.064 13.3 5.7 1.1 9.4 3.0 2.3 2 1 0 2 2 2 0 Protein of unknown function OAD_gamma PF04277.13 ETO21334.1 - 0.76 10.4 0.1 0.76 10.4 0.1 3.1 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF4079 PF13301.6 ETO21334.1 - 0.98 9.6 5.9 0.52 10.5 2.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4079) DHHC PF01529.20 ETO21334.1 - 6 7.0 12.8 2.1 8.5 3.6 2.9 3 0 0 3 3 3 0 DHHC palmitoyltransferase CopD PF05425.13 ETO21334.1 - 6.6 7.2 7.5 0.51 10.8 0.5 2.4 2 1 1 3 3 3 0 Copper resistance protein D 7TMR-HDED PF07697.11 ETO21335.1 - 1.8 8.6 10.4 3.1 7.8 10.4 1.4 1 0 0 1 1 1 0 7TM-HD extracellular MscS_TM PF12794.7 ETO21335.1 - 3 6.6 4.8 4 6.2 4.8 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Pex14_N PF04695.13 ETO21335.1 - 6.7 7.3 18.8 0.19 12.4 9.1 2.1 1 1 1 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DNA_pol_A_exo1 PF01612.20 ETO21336.1 - 0.00052 19.8 0.4 0.0015 18.3 0.1 1.9 2 0 0 2 2 2 1 3'-5' exonuclease LexA_DNA_bind PF01726.16 ETO21336.1 - 0.036 13.8 0.0 1.6 8.5 0.0 2.5 2 0 0 2 2 2 0 LexA DNA binding domain DEP PF00610.21 ETO21337.1 - 7.9e-10 38.7 0.1 1.4e-09 37.9 0.1 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) LAP1C PF05609.12 ETO21337.1 - 0.04 13.0 18.2 0.052 12.6 18.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Macoilin PF09726.9 ETO21337.1 - 0.09 11.3 16.4 0.1 11.2 16.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF2457 PF10446.9 ETO21337.1 - 0.42 9.7 30.9 0.69 9.0 30.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Hid1 PF12722.7 ETO21337.1 - 0.44 8.6 10.5 0.54 8.3 10.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CDC45 PF02724.14 ETO21337.1 - 0.65 8.2 21.0 0.93 7.7 21.0 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO21337.1 - 0.91 7.7 26.3 1.2 7.3 26.3 1.3 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 ETO21337.1 - 1.4 6.6 12.4 1.7 6.3 12.4 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SDP_N PF12278.8 ETO21337.1 - 2.3 8.4 8.9 21 5.3 4.1 2.7 2 0 0 2 2 2 0 Sex determination protein N terminal Pes-10 PF07149.11 ETO21337.1 - 4 6.4 18.8 0.72 8.8 15.3 1.5 2 0 0 2 2 2 0 Pes-10 Acyl-CoA_dh_1 PF00441.24 ETO21339.1 - 5.6e-41 140.2 0.7 7.3e-41 139.9 0.7 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETO21339.1 - 4.9e-18 65.8 0.0 1.3e-17 64.4 0.0 1.8 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETO21339.1 - 1.5e-16 60.4 0.0 2.4e-16 59.7 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETO21339.1 - 7e-08 32.8 0.0 1.1e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Pox_Ag35 PF03286.14 ETO21340.1 - 0.033 14.0 3.5 0.061 13.1 3.5 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO21340.1 - 0.053 12.9 6.0 0.087 12.1 6.0 1.3 1 0 0 1 1 1 0 NOA36 protein Gemini_AC4_5_2 PF08464.10 ETO21340.1 - 0.11 12.4 0.1 0.28 11.2 0.1 1.6 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region SOSSC PF15925.5 ETO21340.1 - 0.54 11.6 2.9 0.87 10.9 0.6 2.5 2 1 0 2 2 2 0 SOSS complex subunit C CENP-B_dimeris PF09026.10 ETO21340.1 - 2 8.8 11.8 4.3 7.8 11.8 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ETO21340.1 - 7.1 6.3 12.4 13 5.4 12.4 1.4 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 ETO21340.1 - 9.5 4.2 7.5 12 3.8 7.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi TIM21 PF08294.11 ETO21343.1 - 6.4e-05 22.9 11.9 7.1e-05 22.7 0.1 2.9 4 0 0 4 4 4 2 TIM21 UPF0524 PF15823.5 ETO21343.1 - 0.032 13.6 2.1 0.058 12.8 2.1 1.5 1 0 0 1 1 1 0 UPF0524 of C3orf70 DUF4481 PF14800.6 ETO21343.1 - 0.085 12.3 2.7 3 7.2 0.2 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4481) Coa1 PF08695.10 ETO21343.1 - 0.13 12.0 0.5 0.33 10.7 0.0 2.0 2 1 1 3 3 3 0 Cytochrome oxidase complex assembly protein 1 DUF4282 PF14110.6 ETO21343.1 - 1.2 9.9 6.1 4.1 8.2 6.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4282) DUF543 PF04418.12 ETO21344.1 - 0.037 14.0 0.5 0.27 11.2 0.1 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF543) SH3_4 PF06347.13 ETO21344.1 - 0.062 13.1 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain ENTH PF01417.20 ETO21344.1 - 0.067 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 ENTH domain DUF3439 PF11921.8 ETO21345.1 - 0.2 11.7 10.9 0.39 10.7 10.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO21345.1 - 0.63 8.0 12.5 0.86 7.5 12.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 ETO21345.1 - 2.2 6.4 19.9 3.2 5.9 19.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 IBN_N PF03810.19 ETO21346.1 - 7.3e-06 25.8 6.4 9.3e-05 22.3 0.2 3.0 2 1 1 3 3 3 2 Importin-beta N-terminal domain HEAT_2 PF13646.6 ETO21346.1 - 0.006 16.9 0.1 0.014 15.7 0.0 1.6 2 0 0 2 2 2 1 HEAT repeats DUF1746 PF08508.10 ETO21346.1 - 0.085 13.2 0.2 0.13 12.6 0.2 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1746) Mito_carr PF00153.27 ETO21347.1 - 5.6e-09 35.8 2.9 0.0055 16.6 0.6 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein ArfGap PF01412.18 ETO21348.1 - 7.7e-31 106.6 0.9 4.1e-30 104.2 0.9 2.1 1 1 0 1 1 1 1 Putative GTPase activating protein for Arf Ank_2 PF12796.7 ETO21348.1 - 1.1e-07 32.3 0.1 2.8e-07 31.0 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO21348.1 - 5.9e-06 26.5 0.6 0.00052 20.3 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO21348.1 - 0.008 16.5 0.0 0.017 15.4 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21348.1 - 0.02 15.4 0.0 0.51 11.1 0.0 3.0 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 ETO21348.1 - 0.027 15.0 0.0 0.088 13.4 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) zf-RanBP PF00641.18 ETO21349.1 - 7.2e-06 25.2 27.3 0.00058 19.1 2.0 3.4 2 1 1 3 3 3 2 Zn-finger in Ran binding protein and others BSP_II PF05432.11 ETO21349.1 - 0.00079 19.2 13.7 0.0015 18.3 13.7 1.5 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) CDC27 PF09507.10 ETO21349.1 - 0.0031 17.0 26.2 0.0044 16.5 26.2 1.2 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 DZR PF12773.7 ETO21349.1 - 0.016 15.3 22.6 0.17 12.0 10.3 2.4 1 1 1 2 2 2 0 Double zinc ribbon Vps36-NZF-N PF16988.5 ETO21349.1 - 0.043 13.2 0.5 0.043 13.2 0.5 3.7 3 0 0 3 3 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain FAM176 PF14851.6 ETO21349.1 - 0.053 13.2 9.4 0.13 11.9 9.4 1.7 1 0 0 1 1 1 0 FAM176 family DUF2052 PF09747.9 ETO21349.1 - 0.22 11.6 17.7 0.067 13.3 14.7 1.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) SAPS PF04499.15 ETO21349.1 - 0.25 10.1 6.0 0.29 9.9 6.0 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CCSAP PF15748.5 ETO21349.1 - 0.38 10.9 18.0 0.68 10.1 18.0 1.5 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Ima1_N PF09779.9 ETO21349.1 - 0.73 10.7 0.1 0.73 10.7 0.1 4.5 3 1 1 4 4 4 0 Ima1 N-terminal domain YlzJ PF14035.6 ETO21349.1 - 0.82 9.9 4.5 45 4.4 3.2 2.6 2 0 0 2 2 2 0 YlzJ-like protein Red1 PF07964.11 ETO21349.1 - 2.2 6.4 23.0 3.1 5.9 23.0 1.2 1 0 0 1 1 1 0 Rec10 / Red1 Zip PF02535.22 ETO21349.1 - 4.4 6.4 5.8 6 6.0 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 ETO21349.1 - 5.5 5.0 15.1 7.3 4.6 15.1 1.2 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO21349.1 - 9.6 4.8 10.2 13 4.4 10.2 1.2 1 0 0 1 1 1 0 Presenilin RhoGAP PF00620.27 ETO21352.1 - 5.7e-09 36.0 0.0 7.6e-09 35.6 0.0 1.2 1 0 0 1 1 1 1 RhoGAP domain RPEL PF02755.15 ETO21353.1 - 4.6e-09 35.7 63.4 1.3e-05 24.7 0.4 13.1 15 0 0 15 15 15 8 RPEL repeat Sterol_MT_C PF08498.10 ETO21356.1 - 4.8e-21 74.8 0.0 9.9e-21 73.8 0.0 1.5 1 0 0 1 1 1 1 Sterol methyltransferase C-terminal Methyltransf_11 PF08241.12 ETO21356.1 - 3e-13 50.2 0.1 9.1e-13 48.7 0.1 1.8 1 1 0 1 1 1 1 Methyltransferase domain CMAS PF02353.20 ETO21356.1 - 5e-12 45.7 0.2 1.8e-11 43.9 0.2 1.9 1 1 0 1 1 1 1 Mycolic acid cyclopropane synthetase Methyltransf_31 PF13847.6 ETO21356.1 - 4.1e-11 42.9 0.8 3e-10 40.1 0.8 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO21356.1 - 8.5e-11 42.4 0.1 3.9e-10 40.3 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO21356.1 - 1.6e-08 34.6 0.0 3.9e-08 33.3 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO21356.1 - 6e-06 26.9 0.0 2.1e-05 25.2 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO21356.1 - 0.00032 20.1 0.0 0.00052 19.4 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family WavE PF07507.11 ETO21356.1 - 0.078 12.1 0.1 0.12 11.6 0.1 1.2 1 0 0 1 1 1 0 WavE lipopolysaccharide synthesis Hydrolase PF00702.26 ETO21357.1 - 5.1e-21 75.9 1.6 1.5e-08 35.2 0.0 3.5 3 1 0 3 3 3 3 haloacid dehalogenase-like hydrolase Cation_ATPase_C PF00689.21 ETO21357.1 - 7.9e-18 64.8 1.6 7.9e-18 64.8 1.6 2.1 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus Cation_ATPase PF13246.6 ETO21357.1 - 3.3e-12 46.3 0.1 8.7e-12 45.0 0.1 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ETO21357.1 - 7.5e-10 38.6 1.1 7.5e-10 38.6 1.1 1.7 2 0 0 2 2 2 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ETO21357.1 - 5.4e-06 26.3 9.2 0.0015 18.4 1.9 3.3 4 0 0 4 4 4 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO21357.1 - 0.014 15.8 0.0 0.13 12.6 0.0 2.3 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase Hydrolase_6 PF13344.6 ETO21357.1 - 0.022 14.9 0.0 0.06 13.5 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Taxilin PF09728.9 ETO21358.1 - 0.00021 20.6 57.5 0.00021 20.6 57.5 4.1 2 1 1 3 3 3 1 Myosin-like coiled-coil protein Filament PF00038.21 ETO21358.1 - 0.0035 17.0 46.6 0.0035 17.0 46.6 4.5 1 1 3 4 4 4 1 Intermediate filament protein ADIP PF11559.8 ETO21358.1 - 0.0094 16.0 14.9 0.0094 16.0 14.9 7.3 3 3 4 7 7 7 2 Afadin- and alpha -actinin-Binding ZapB PF06005.12 ETO21358.1 - 0.019 15.4 9.0 0.019 15.4 9.0 9.9 4 3 5 9 9 9 0 Cell division protein ZapB APG6_N PF17675.1 ETO21358.1 - 0.024 15.2 17.0 0.024 15.2 17.0 7.6 1 1 4 6 6 6 0 Apg6 coiled-coil region GAS PF13851.6 ETO21358.1 - 0.57 9.5 119.3 0.017 14.5 23.5 6.6 2 1 6 8 8 8 0 Growth-arrest specific micro-tubule binding ATG16 PF08614.11 ETO21358.1 - 1.8 8.7 99.1 0.052 13.8 12.7 7.0 2 2 5 7 7 7 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ETO21358.1 - 3.8 7.9 101.1 0.45 10.9 18.0 5.2 1 1 4 5 5 5 0 Fez1 DUF2119 PF09892.9 ETO21359.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2119) EF-hand_8 PF13833.6 ETO21361.1 - 2.3e-05 24.1 13.4 0.016 15.0 0.1 3.9 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO21361.1 - 3.8e-05 23.3 12.0 0.04 13.9 0.2 5.1 5 0 0 5 5 4 2 EF-hand domain EF-hand_1 PF00036.32 ETO21361.1 - 4.1e-05 22.8 16.5 0.008 15.7 0.2 4.6 4 0 0 4 4 4 2 EF hand DNA_pol_phi PF04931.13 ETO21361.1 - 0.0016 16.6 16.8 0.0039 15.4 16.8 1.6 1 0 0 1 1 1 1 DNA polymerase phi EF-hand_7 PF13499.6 ETO21361.1 - 0.0018 18.7 20.2 0.087 13.3 0.1 5.1 4 1 0 4 4 4 2 EF-hand domain pair Cwf_Cwc_15 PF04889.12 ETO21361.1 - 0.0056 16.4 15.1 0.0056 16.4 15.1 3.0 3 1 0 3 3 2 1 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETO21361.1 - 0.0091 14.3 12.9 0.016 13.5 12.9 1.4 1 0 0 1 1 1 1 CDC45-like protein CENP-B_dimeris PF09026.10 ETO21361.1 - 0.026 14.9 22.4 0.026 14.9 22.4 3.4 3 1 0 3 3 3 0 Centromere protein B dimerisation domain Nnf1 PF03980.14 ETO21361.1 - 0.069 13.5 2.1 0.25 11.8 2.1 1.9 1 0 0 1 1 1 0 Nnf1 Vfa1 PF08432.10 ETO21361.1 - 0.2 11.9 11.9 0.02 15.2 6.5 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF1676 PF07898.13 ETO21361.1 - 0.48 10.4 0.0 0.48 10.4 0.0 2.7 3 0 0 3 3 2 0 Protein of unknown function (DUF1676) SnAPC_2_like PF11035.8 ETO21361.1 - 1 9.4 5.1 0.19 11.8 0.3 2.2 2 0 0 2 2 2 0 Small nuclear RNA activating complex subunit 2, SNAP190 Myb Orf78 PF06024.12 ETO21361.1 - 2.1 8.7 10.2 0.17 12.2 1.7 2.7 2 0 0 2 2 2 0 Orf78 (ac78) TFB6 PF17110.5 ETO21361.1 - 2.4 7.9 11.5 0.52 10.0 7.2 2.1 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Utp14 PF04615.13 ETO21361.1 - 2.7 6.5 17.3 6.4 5.2 14.5 2.4 2 0 0 2 2 2 0 Utp14 protein Neur_chan_memb PF02932.16 ETO21361.1 - 3.6 7.6 9.4 27 4.7 9.4 2.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region GCIP PF13324.6 ETO21361.1 - 4.1 6.9 13.8 0.43 10.2 8.4 2.0 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting PBP1_TM PF14812.6 ETO21361.1 - 4.4 7.7 30.3 1.1 9.7 17.3 4.0 4 0 0 4 4 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ANAPC15 PF15243.6 ETO21361.1 - 5.1 7.6 26.6 0.69 10.4 20.4 2.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 TFIIA PF03153.13 ETO21361.1 - 7.5 6.4 20.3 1.5 8.7 16.2 1.9 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit RasGEF_N PF00618.20 ETO21362.1 - 2.3e-06 27.8 0.0 6.6e-06 26.3 0.0 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif ELFV_dehydrog_N PF02812.18 ETO21363.1 - 7.5e-23 80.8 0.0 1.1e-22 80.4 0.0 1.2 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 ETO21363.1 - 1.6e-21 77.2 0.3 2e-21 76.9 0.3 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase DUF2457 PF10446.9 ETO21364.1 - 0.27 10.3 19.3 0.35 10.0 19.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TRAM_LAG1_CLN8 PF03798.16 ETO21364.1 - 1 9.0 5.8 2.8 7.6 5.4 1.5 1 1 0 1 1 1 0 TLC domain Zip PF02535.22 ETO21364.1 - 2 7.6 4.0 2.7 7.1 4.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO21364.1 - 2.5 6.3 14.2 3.2 6.0 14.2 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO21364.1 - 6.4 5.2 15.3 7.7 4.9 15.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 WD40 PF00400.32 ETO21366.1 - 0.14 13.1 0.2 8.8 7.4 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat DUF1910 PF08928.10 ETO21369.1 - 0.028 14.4 0.3 0.073 13.1 0.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1910) Beach PF02138.18 ETO21370.1 - 8.2e-33 114.0 0.0 1.1e-32 113.5 0.0 1.2 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 ETO21370.1 - 7.9e-07 29.7 3.0 0.00048 20.9 0.0 3.4 4 0 0 4 4 4 2 WD domain, G-beta repeat CNF1 PF05785.12 ETO21370.1 - 0.15 11.3 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 Rho-activating domain of cytotoxic necrotizing factor DUF2457 PF10446.9 ETO21371.1 - 0.0074 15.5 14.6 0.012 14.8 14.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) WD40_like PF17005.5 ETO21371.1 - 0.012 14.9 0.2 0.023 14.0 0.1 1.5 1 1 1 2 2 2 0 WD40-like domain ANAPC4_WD40 PF12894.7 ETO21371.1 - 0.015 15.6 0.0 1.1 9.6 0.0 2.8 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Cwf_Cwc_15 PF04889.12 ETO21371.1 - 0.023 14.4 11.8 0.036 13.8 11.8 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 ETO21371.1 - 0.14 11.5 12.0 0.21 10.9 12.0 1.2 1 0 0 1 1 1 0 BUD22 DUF2076 PF09849.9 ETO21371.1 - 0.19 11.8 8.5 0.25 11.4 8.5 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Nop14 PF04147.12 ETO21371.1 - 0.21 9.8 9.8 0.26 9.5 9.8 1.2 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 ETO21371.1 - 0.33 10.5 14.0 0.51 9.9 14.0 1.3 1 0 0 1 1 1 0 PPP4R2 CDC27 PF09507.10 ETO21371.1 - 0.51 9.7 12.1 0.74 9.1 12.1 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIA PF03153.13 ETO21371.1 - 0.73 9.8 15.1 0.99 9.3 15.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 ETO21371.1 - 1.3 7.2 8.6 2.4 6.3 8.6 1.4 1 0 0 1 1 1 0 CDC45-like protein PBP1_TM PF14812.6 ETO21371.1 - 3 8.3 14.9 6.2 7.3 14.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Chal_sti_synt_N PF00195.19 ETO21372.1 - 6.2e-21 74.9 0.0 8.4e-21 74.4 0.0 1.1 1 0 0 1 1 1 1 Chalcone and stilbene synthases, N-terminal domain FAE1_CUT1_RppA PF08392.12 ETO21372.1 - 0.00072 18.9 0.0 0.0011 18.3 0.0 1.3 1 0 0 1 1 1 1 FAE1/Type III polyketide synthase-like protein Chal_sti_synt_C PF02797.15 ETO21372.1 - 0.00072 19.6 0.0 0.0021 18.1 0.0 1.7 2 0 0 2 2 2 1 Chalcone and stilbene synthases, C-terminal domain fn3 PF00041.21 ETO21374.1 - 0.0021 18.3 0.0 0.0089 16.4 0.0 2.1 3 0 0 3 3 3 1 Fibronectin type III domain Imm7 PF15585.6 ETO21375.1 - 0.074 13.3 0.1 0.29 11.4 0.0 2.0 2 0 0 2 2 2 0 Immunity protein 7 Fzo_mitofusin PF04799.13 ETO21375.1 - 0.65 9.5 8.3 0.51 9.9 1.6 3.1 3 0 0 3 3 3 0 fzo-like conserved region TetR PF13972.6 ETO21375.1 - 2.2 8.0 7.1 1.3 8.7 0.1 3.1 2 1 0 3 3 3 0 Bacterial transcriptional repressor CdvA PF18822.1 ETO21375.1 - 8.4 6.3 10.9 2.7 7.9 0.2 3.4 3 1 0 3 3 3 0 CdvA-like coiled-coil domain bZIP_1 PF00170.21 ETO21376.1 - 0.045 13.9 4.0 0.045 13.9 4.0 2.4 1 1 1 2 2 2 0 bZIP transcription factor CENP-F_leu_zip PF10473.9 ETO21376.1 - 0.059 13.4 13.0 0.044 13.8 7.1 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 ETO21376.1 - 0.57 10.7 14.0 0.3 11.6 7.5 2.1 2 0 0 2 2 2 0 Apg6 coiled-coil region Phage_GPO PF05929.11 ETO21376.1 - 4.3 6.9 17.6 1.9 8.1 4.5 2.0 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase YtxH PF12732.7 ETO21376.1 - 6.9 7.3 6.2 5.2 7.7 1.3 2.3 2 0 0 2 2 2 0 YtxH-like protein DUF2383 PF09537.10 ETO21377.1 - 0.028 14.8 0.0 0.11 12.9 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2383) WD40 PF00400.32 ETO21378.1 - 1.1e-123 399.5 53.5 1e-08 35.7 0.1 16.3 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21378.1 - 5.6e-32 109.9 6.9 0.033 14.5 0.0 12.1 2 2 10 13 13 13 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21378.1 - 4.3e-14 52.2 7.1 2.7 6.9 0.0 12.3 1 1 14 15 15 15 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO21378.1 - 5e-14 51.9 22.6 0.36 9.4 1.1 12.5 3 3 5 12 12 12 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO21378.1 - 2.2e-12 46.9 0.6 0.021 14.2 0.0 6.7 4 2 1 7 7 7 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO21378.1 - 8.2e-08 31.2 8.3 0.41 9.1 0.2 6.1 5 1 1 6 6 6 3 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO21378.1 - 1.5e-06 28.0 3.3 0.03 13.9 0.1 4.6 2 2 1 3 3 3 2 PQQ-like domain Pentapeptide PF00805.22 ETO21378.1 - 3.6e-06 26.5 4.3 8e-06 25.4 4.3 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DUF5046 PF16465.5 ETO21378.1 - 1.2e-05 24.9 0.0 1.2 8.5 0.0 4.2 3 1 0 4 4 4 2 Domain of unknown function (DUF5046) Str_synth PF03088.16 ETO21378.1 - 0.00043 20.3 1.8 6.2 7.0 0.0 7.0 7 1 2 9 9 9 1 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO21378.1 - 0.00051 20.2 0.1 0.0015 18.7 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO21378.1 - 0.0011 19.0 11.5 1.1 9.3 0.1 6.9 3 3 4 7 7 7 1 Family of unknown function (DUF5570) Pentapeptide_3 PF13576.6 ETO21378.1 - 0.0061 16.7 0.4 0.051 13.7 0.2 2.6 3 0 0 3 3 3 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO21378.1 - 0.021 14.2 11.3 1.3 8.3 0.8 6.5 4 4 3 8 8 8 0 Neuroblastoma-amplified sequence, N terminal DUF3475 PF11961.8 ETO21378.1 - 0.028 14.5 0.0 24 5.1 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF3475) PQQ PF01011.21 ETO21378.1 - 0.074 13.0 0.0 1e+02 3.1 0.0 4.9 4 0 0 4 4 4 0 PQQ enzyme repeat Ricin_B_lectin PF00652.22 ETO21378.1 - 0.19 12.0 9.4 13 6.0 0.0 5.9 6 1 1 7 7 7 0 Ricin-type beta-trefoil lectin domain PD40 PF07676.12 ETO21378.1 - 0.25 11.3 18.5 31 4.6 0.0 8.6 10 0 0 10 10 9 0 WD40-like Beta Propeller Repeat NACHT PF05729.12 ETO21379.1 - 1.3e-10 41.5 0.0 4.4e-10 39.7 0.0 2.0 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO21379.1 - 0.0002 21.9 0.1 0.0011 19.5 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO21379.1 - 0.0014 18.9 0.1 0.0075 16.5 0.1 2.2 1 1 0 1 1 1 1 AAA domain ATP_bind_2 PF03668.15 ETO21379.1 - 0.023 14.0 0.0 0.049 12.9 0.0 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family AAA_33 PF13671.6 ETO21379.1 - 0.042 14.0 0.0 3.4 7.8 0.0 2.7 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO21379.1 - 0.059 13.8 0.4 0.46 10.9 0.1 2.8 2 1 0 2 2 2 0 RNA helicase BCNT PF07572.12 ETO21379.1 - 0.14 12.2 3.0 0.19 11.8 0.7 2.5 2 0 0 2 2 2 0 Bucentaur or craniofacial development PS_Dcarbxylase PF02666.15 ETO21380.1 - 5.7e-16 58.7 0.0 7e-16 58.4 0.0 1.0 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Biotin_lipoyl_2 PF13533.6 ETO21380.1 - 0.013 15.3 0.0 3.7 7.5 0.0 2.9 3 0 0 3 3 3 0 Biotin-lipoyl like zinc_ribbon_11 PF11682.8 ETO21380.1 - 0.073 13.1 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Probable zinc-ribbon DUF2457 PF10446.9 ETO21382.1 - 0.0046 16.2 22.9 0.008 15.4 22.9 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO21382.1 - 0.013 13.9 18.9 0.014 13.7 18.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO21382.1 - 0.028 13.9 24.8 0.035 13.5 24.8 1.2 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO21382.1 - 0.042 12.1 29.3 0.054 11.7 29.3 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO21382.1 - 0.31 10.3 22.3 0.39 10.0 22.3 1.2 1 0 0 1 1 1 0 BUD22 CLN3 PF02487.17 ETO21382.1 - 0.39 9.7 2.9 0.6 9.1 2.9 1.2 1 0 0 1 1 1 0 CLN3 protein YL1 PF05764.13 ETO21382.1 - 0.52 10.4 23.4 0.69 10.0 23.4 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Peptidase_S64 PF08192.11 ETO21382.1 - 2.2 6.7 7.7 3 6.2 7.7 1.1 1 0 0 1 1 1 0 Peptidase family S64 NYD-SP28_assoc PF14775.6 ETO21384.1 - 0.014 15.5 0.7 0.032 14.3 0.7 1.7 1 0 0 1 1 1 0 Sperm tail C-terminal domain RGS PF00615.19 ETO21384.1 - 0.032 14.5 0.5 0.061 13.6 0.5 1.5 1 0 0 1 1 1 0 Regulator of G protein signaling domain HAGH_C PF16123.5 ETO21384.1 - 0.11 13.0 0.3 0.28 11.7 0.1 1.8 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus PIG-P PF08510.12 ETO21384.1 - 0.15 12.0 4.5 0.25 11.3 2.5 2.3 3 0 0 3 3 3 0 PIG-P UN_NPL4 PF11543.8 ETO21385.1 - 0.0018 18.7 5.3 0.005 17.3 0.6 3.5 2 1 1 3 3 3 1 Nuclear pore localisation protein NPL4 DUF2457 PF10446.9 ETO21385.1 - 0.0025 17.0 22.0 0.0025 17.0 22.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF2457) 4HFCP_synth PF04476.13 ETO21385.1 - 0.06 13.1 0.2 0.13 12.0 0.2 1.5 1 0 0 1 1 1 0 4-HFC-P synthase CDC45 PF02724.14 ETO21385.1 - 0.066 11.5 19.1 0.028 12.7 15.1 1.9 2 0 0 2 2 2 0 CDC45-like protein E2_bind PF08825.10 ETO21385.1 - 0.19 11.9 3.2 0.29 11.3 1.9 2.0 2 0 0 2 2 2 0 E2 binding domain Zip PF02535.22 ETO21385.1 - 0.36 10.0 7.0 0.72 9.0 7.0 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter Na_trans_assoc PF06512.13 ETO21385.1 - 4.1 7.6 21.6 0.59 10.4 15.1 2.6 2 1 0 2 2 2 0 Sodium ion transport-associated G-alpha PF00503.20 ETO21386.1 - 4.2e-44 151.1 27.9 9.2e-22 77.7 20.9 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO21386.1 - 8.8e-06 25.3 0.3 0.021 14.3 0.0 3.3 3 0 0 3 3 3 2 ADP-ribosylation factor family AAA_16 PF13191.6 ETO21386.1 - 0.0024 18.3 0.0 0.0052 17.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ETO21386.1 - 0.0044 17.5 0.8 0.48 10.9 0.0 2.7 2 0 0 2 2 2 1 ABC transporter Utp14 PF04615.13 ETO21386.1 - 0.079 11.5 8.0 0.11 11.1 8.0 1.1 1 0 0 1 1 1 0 Utp14 protein CSRNP_N PF16019.5 ETO21386.1 - 3.4 7.5 9.3 0.47 10.3 4.9 1.8 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus MFS_1 PF07690.16 ETO21387.1 - 1.4e-06 27.5 15.8 5.1e-06 25.6 15.4 2.0 1 1 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO21387.1 - 3.2e-05 23.0 0.3 3.2e-05 23.0 0.3 1.9 1 1 1 2 2 2 1 Sugar (and other) transporter TMEM208_SND2 PF05620.11 ETO21387.1 - 3.3 7.5 10.6 7.1 6.4 5.3 2.6 2 1 1 3 3 3 0 SRP-independent targeting protein 2/TMEM208 ELO PF01151.18 ETO21388.1 - 2.9e-18 66.3 4.7 3.8e-18 65.9 4.7 1.1 1 0 0 1 1 1 1 GNS1/SUR4 family Aldolase_II PF00596.21 ETO21389.1 - 2.1e-18 67.0 0.1 3.1e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain MFS_1 PF07690.16 ETO21391.1 - 5.1e-16 58.5 19.2 8e-16 57.9 7.2 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETO21391.1 - 4.3e-09 35.4 6.9 4.3e-09 35.4 6.9 1.9 1 1 1 2 2 2 1 MFS/sugar transport protein ATG22 PF11700.8 ETO21391.1 - 0.25 9.9 8.8 0.02 13.5 1.8 2.3 3 0 0 3 3 3 0 Vacuole effluxer Atg22 like MerC PF03203.14 ETO21391.1 - 5.2 7.5 9.6 4.7 7.7 5.4 2.8 2 1 0 2 2 2 0 MerC mercury resistance protein Zip PF02535.22 ETO21392.1 - 0.0047 16.2 0.2 0.011 15.0 0.2 1.7 1 1 0 1 1 1 1 ZIP Zinc transporter DUF4519 PF15012.6 ETO21392.1 - 0.021 15.0 3.3 0.059 13.5 3.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4519) Anoctamin PF04547.12 ETO21392.1 - 0.044 12.6 0.2 0.057 12.3 0.2 1.1 1 0 0 1 1 1 0 Calcium-activated chloride channel CrgA PF06781.12 ETO21392.1 - 0.23 11.6 1.7 0.23 11.5 0.0 1.9 2 0 0 2 2 2 0 Cell division protein CrgA DUF3464 PF11947.8 ETO21392.1 - 2.7 7.7 6.0 11 5.8 0.0 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 FAM176 PF14851.6 ETO21392.1 - 4.2 7.0 7.1 1.8 8.3 4.5 1.8 2 0 0 2 2 2 0 FAM176 family Orf78 PF06024.12 ETO21392.1 - 6.1 7.2 15.8 0.86 9.9 0.2 2.4 2 0 0 2 2 2 0 Orf78 (ac78) DNA_pol_phi PF04931.13 ETO21392.1 - 9.3 4.2 19.7 0.36 8.9 14.4 1.3 2 0 0 2 2 2 0 DNA polymerase phi Kinesin PF00225.23 ETO21393.1 - 3e-105 351.8 8.9 3e-105 351.8 8.9 4.1 3 2 0 4 4 4 1 Kinesin motor domain Microtub_bd PF16796.5 ETO21393.1 - 4.4e-22 78.6 0.1 4.4e-22 78.6 0.1 4.1 3 1 0 3 3 3 1 Microtubule binding Roc PF08477.13 ETO21393.1 - 0.021 15.0 0.8 1.1 9.5 0.1 3.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_helicase PF00910.22 ETO21393.1 - 0.029 14.7 0.7 0.32 11.4 0.0 3.2 4 0 0 4 4 4 0 RNA helicase NACHT PF05729.12 ETO21393.1 - 0.037 13.9 0.3 0.9 9.4 0.0 3.0 2 1 1 3 3 3 0 NACHT domain AAA_16 PF13191.6 ETO21393.1 - 0.069 13.5 0.0 0.38 11.1 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain DUF3974 PF13120.6 ETO21393.1 - 0.61 10.2 3.7 2.5 8.2 3.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3974) AAA_22 PF13401.6 ETO21393.1 - 1.4 9.2 0.0 1.4 9.2 0.0 3.2 4 1 0 4 4 4 0 AAA domain Rad1 PF02144.16 ETO21394.1 - 9.8e-11 41.2 7.3 1.1e-07 31.2 1.9 2.9 2 1 0 2 2 2 2 Repair protein Rad1/Rec1/Rad17 PMSR PF01625.21 ETO21395.1 - 2.7e-21 76.4 4.4 3.1e-21 76.1 4.4 1.1 1 0 0 1 1 1 1 Peptide methionine sulfoxide reductase DUF3909 PF13077.6 ETO21395.1 - 0.00071 19.7 0.5 0.00093 19.3 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3909) YvbH_ext PF11724.8 ETO21395.1 - 0.037 14.3 0.6 0.062 13.6 0.6 1.4 1 0 0 1 1 1 0 YvbH-like oligomerisation region Arf PF00025.21 ETO21398.1 - 1.3e-10 41.0 0.0 2.6e-10 40.0 0.0 1.5 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO21398.1 - 2.3e-06 27.8 0.0 6.7e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Gtr1_RagA PF04670.12 ETO21398.1 - 0.037 13.4 0.0 0.091 12.1 0.0 1.7 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region Ras PF00071.22 ETO21398.1 - 0.042 13.5 0.0 0.088 12.4 0.0 1.5 1 0 0 1 1 1 0 Ras family AAA_8 PF12780.7 ETO21398.1 - 0.083 12.2 1.7 1.3 8.3 0.3 2.6 2 0 0 2 2 2 0 P-loop containing dynein motor region D4 TetR_C_19 PF17924.1 ETO21398.1 - 0.29 11.7 2.4 0.45 11.1 0.4 2.3 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Exo_endo_phos PF03372.23 ETO21399.1 - 0.00025 20.6 0.0 0.00029 20.4 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RimK PF08443.11 ETO21400.1 - 1.2e-22 80.4 0.0 2e-15 56.9 0.1 2.2 2 0 0 2 2 2 2 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ETO21400.1 - 4e-06 26.3 0.1 6.5e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain PBP1_TM PF14812.6 ETO21400.1 - 0.00055 20.2 3.0 0.013 15.9 0.0 2.5 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal Orf78 PF06024.12 ETO21400.1 - 0.00083 19.6 0.2 0.0025 18.1 0.2 1.8 1 0 0 1 1 1 1 Orf78 (ac78) BIRC6 PF12356.8 ETO21400.1 - 0.059 12.8 0.4 0.11 11.9 0.4 1.3 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 ETRAMP PF09716.10 ETO21400.1 - 0.098 12.7 2.9 0.65 10.1 2.9 2.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TRAM_LAG1_CLN8 PF03798.16 ETO21401.1 - 2e-09 37.5 22.6 2.3e-09 37.3 22.6 1.1 1 0 0 1 1 1 1 TLC domain HAP PF03866.13 ETO21401.1 - 0.014 15.4 0.0 0.023 14.7 0.0 1.3 1 0 0 1 1 1 0 Hydrophobic abundant protein (HAP) DUSP PF06337.12 ETO21403.1 - 1.9e-10 41.2 0.0 1.9e-10 41.2 0.0 2.3 2 1 0 2 2 1 1 DUSP domain CDC45 PF02724.14 ETO21403.1 - 0.0017 16.7 8.3 0.002 16.5 8.3 1.1 1 0 0 1 1 1 1 CDC45-like protein ALMT PF11744.8 ETO21403.1 - 0.0027 16.6 9.1 0.0033 16.3 9.1 1.0 1 0 0 1 1 1 1 Aluminium activated malate transporter DUF4746 PF15928.5 ETO21403.1 - 0.0094 15.4 9.2 0.013 15.0 9.2 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) DDHD PF02862.17 ETO21403.1 - 0.043 14.0 4.0 0.053 13.7 4.0 1.1 1 0 0 1 1 1 0 DDHD domain SID-1_RNA_chan PF13965.6 ETO21403.1 - 0.09 11.2 1.4 0.096 11.1 1.4 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 RPN2_C PF18004.1 ETO21403.1 - 0.13 12.2 14.7 0.19 11.6 14.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2151 PF10221.9 ETO21403.1 - 0.33 9.5 9.6 0.41 9.2 9.6 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator CobT PF06213.12 ETO21403.1 - 0.35 10.2 18.6 0.48 9.8 18.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 ETO21403.1 - 0.36 11.2 7.6 0.55 10.6 7.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 FAM176 PF14851.6 ETO21403.1 - 0.6 9.8 10.3 0.97 9.1 10.3 1.4 1 0 0 1 1 1 0 FAM176 family TERB2 PF15101.6 ETO21403.1 - 1.2 9.2 8.8 1.6 8.7 8.8 1.2 1 0 0 1 1 1 0 Telomere-associated protein TERB2 TRAP_alpha PF03896.16 ETO21403.1 - 1.4 8.0 8.6 1.9 7.6 8.6 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit AAA_11 PF13086.6 ETO21403.1 - 1.5 8.6 10.9 2 8.1 10.9 1.1 1 0 0 1 1 1 0 AAA domain DUF4637 PF15470.6 ETO21403.1 - 1.5 8.5 12.3 2.4 7.9 12.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF913 PF06025.12 ETO21403.1 - 1.7 7.5 7.7 2.3 7.1 7.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) HSP70 PF00012.20 ETO21403.1 - 2 6.5 13.6 2.6 6.1 13.6 1.1 1 0 0 1 1 1 0 Hsp70 protein Neur_chan_memb PF02932.16 ETO21403.1 - 2.7 8.0 4.8 3.5 7.6 4.8 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4820 PF16091.5 ETO21403.1 - 3.6 6.9 10.2 5.3 6.3 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RPA43_OB PF17875.1 ETO21403.1 - 3.6 8.2 9.3 6 7.5 9.3 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Vfa1 PF08432.10 ETO21403.1 - 3.8 7.8 19.0 5.4 7.3 19.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF4642 PF15484.6 ETO21403.1 - 4.5 7.5 16.2 5.2 7.3 15.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4642) DNA_pol_phi PF04931.13 ETO21403.1 - 4.8 5.2 18.9 6.3 4.8 18.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi Sec62 PF03839.16 ETO21403.1 - 5.4 6.5 9.8 8.2 5.9 9.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO21403.1 - 6.9 5.3 11.9 9.3 4.9 11.9 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 ETO21403.1 - 7 6.6 11.8 11 6.0 11.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A RR_TM4-6 PF06459.12 ETO21403.1 - 7.6 6.3 17.8 10 5.8 17.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO21403.1 - 8.3 5.5 6.4 11 5.2 6.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_U57 PF05582.12 ETO21403.1 - 8.8 5.5 7.8 13 5.0 7.8 1.2 1 0 0 1 1 1 0 YabG peptidase U57 NPR3 PF03666.13 ETO21404.1 - 1.5 7.5 8.9 1.8 7.3 8.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO21404.1 - 2 7.1 6.9 2.3 6.9 6.9 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO21404.1 - 3.5 6.7 4.2 3.8 6.6 4.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MFS_2 PF13347.6 ETO21405.1 - 2.8e-05 22.8 5.0 2.8e-05 22.8 5.0 2.2 2 1 1 3 3 3 1 MFS/sugar transport protein MFS_1 PF07690.16 ETO21405.1 - 6.3e-05 22.1 17.5 0.00012 21.2 17.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily DAO PF01266.24 ETO21406.1 - 0.0019 17.8 0.0 0.0029 17.3 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase ATG16 PF08614.11 ETO21407.1 - 0.00022 21.5 16.6 0.00033 20.9 16.6 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) AAA_23 PF13476.6 ETO21407.1 - 0.011 16.3 3.3 0.015 15.8 3.3 1.2 1 0 0 1 1 1 0 AAA domain Atg14 PF10186.9 ETO21407.1 - 0.032 13.3 13.3 0.042 12.9 13.3 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4093 PF13331.6 ETO21407.1 - 0.032 14.7 3.6 0.069 13.6 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Exonuc_VII_L PF02601.15 ETO21407.1 - 0.086 12.4 10.0 0.11 12.1 10.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ETO21407.1 - 0.19 11.0 10.0 0.29 10.5 10.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mod_r PF07200.13 ETO21407.1 - 0.32 11.1 16.6 0.53 10.4 16.6 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein OmpH PF03938.14 ETO21407.1 - 0.32 11.3 17.9 0.51 10.7 17.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) LUC7 PF03194.15 ETO21407.1 - 0.36 10.5 13.5 0.49 10.0 13.5 1.2 1 0 0 1 1 1 0 LUC7 N_terminus DUF2703 PF10865.8 ETO21407.1 - 1.8 8.8 7.5 1.1 9.5 3.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2703) FUSC PF04632.12 ETO21407.1 - 3.7 6.0 7.4 4.6 5.7 7.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family YlqD PF11068.8 ETO21407.1 - 4.4 7.7 22.6 2.7 8.4 20.4 1.8 1 1 0 1 1 1 0 YlqD protein APG6_N PF17675.1 ETO21407.1 - 4.5 7.8 22.6 12 6.4 22.3 1.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETO21407.1 - 5.1 7.1 10.2 0.93 9.5 5.8 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) FapA PF03961.13 ETO21407.1 - 7.4 5.1 16.3 12 4.4 16.3 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A CENP-H PF05837.12 ETO21407.1 - 8.2 6.9 18.0 11 6.5 17.4 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) DUF2681 PF10883.8 ETO21407.1 - 8.6 6.8 17.8 0.69 10.4 8.9 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) CDC45 PF02724.14 ETO21408.1 - 2.8 6.1 12.9 3.2 5.9 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO21408.1 - 6.8 5.8 4.7 6.4 5.9 4.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ORC3_N PF07034.11 ETO21408.1 - 8.6 5.3 7.3 9.5 5.2 7.2 1.2 1 1 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Peptidase_A22B PF04258.13 ETO21409.1 - 1.5e-46 159.2 11.9 2.5e-46 158.5 11.9 1.3 1 0 0 1 1 1 1 Signal peptide peptidase SirB PF04247.12 ETO21409.1 - 0.089 12.9 0.3 0.089 12.9 0.3 3.3 3 1 0 3 3 3 0 Invasion gene expression up-regulator, SirB Phage_CI_repr PF07022.13 ETO21409.1 - 0.38 10.9 1.1 24 5.1 0.0 2.4 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain Pox_Ag35 PF03286.14 ETO21411.1 - 0.47 10.2 16.1 0.66 9.7 16.1 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Connexin PF00029.19 ETO21411.1 - 0.86 9.3 6.7 1.1 8.9 6.7 1.3 1 0 0 1 1 1 0 Connexin Dsh_C PF12316.8 ETO21411.1 - 1 9.7 6.4 1.2 9.4 6.4 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF2076 PF09849.9 ETO21411.1 - 2.1 8.3 10.3 2.1 8.3 10.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RNA_pol_Rpc4 PF05132.14 ETO21411.1 - 2.3 8.7 9.9 3.1 8.2 9.9 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nucleo_P87 PF07267.11 ETO21411.1 - 3 6.6 13.9 3.4 6.4 13.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 UPF0560 PF10577.9 ETO21411.1 - 3.2 6.1 10.5 3.3 6.1 10.5 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 PPL5 PF18168.1 ETO21411.1 - 3.6 6.8 10.0 3.6 6.8 10.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Utp14 PF04615.13 ETO21412.1 - 0.093 11.3 12.7 0.1 11.1 12.7 1.1 1 0 0 1 1 1 0 Utp14 protein Presenilin PF01080.17 ETO21412.1 - 0.13 11.0 13.4 0.18 10.5 13.4 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO21412.1 - 0.31 10.2 8.2 0.34 10.1 8.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4551 PF15087.6 ETO21412.1 - 0.41 9.4 5.7 0.49 9.2 5.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CLN3 PF02487.17 ETO21412.1 - 0.82 8.6 2.0 1 8.3 2.0 1.3 1 0 0 1 1 1 0 CLN3 protein SLC12 PF03522.15 ETO21412.1 - 0.88 8.5 13.8 1.1 8.2 13.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Raftlin PF15250.6 ETO21412.1 - 1 8.0 9.0 1.3 7.7 9.0 1.2 1 0 0 1 1 1 0 Raftlin Dapper PF15268.6 ETO21412.1 - 1.1 8.0 10.4 1.2 7.9 10.4 1.1 1 0 0 1 1 1 0 Dapper Membralin PF09746.9 ETO21412.1 - 1.4 7.8 6.7 1.7 7.6 6.7 1.3 1 0 0 1 1 1 0 Tumour-associated protein CSG2 PF16965.5 ETO21412.1 - 1.8 7.5 6.8 2.3 7.1 6.8 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator NPR3 PF03666.13 ETO21412.1 - 1.9 7.2 19.1 2.2 7.0 19.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 XRN_M PF17846.1 ETO21412.1 - 2.2 7.1 11.9 2.6 6.9 11.9 1.2 1 0 0 1 1 1 0 Xrn1 helical domain ASD2 PF08687.11 ETO21412.1 - 2.6 7.5 7.5 3.8 7.0 7.5 1.4 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 ALMT PF11744.8 ETO21412.1 - 3.4 6.4 14.0 4.3 6.0 14.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PIEZO PF15917.5 ETO21412.1 - 3.8 6.9 9.2 59 3.0 9.2 2.4 1 1 0 1 1 1 0 Piezo Macoilin PF09726.9 ETO21412.1 - 4.1 5.8 22.1 4.7 5.6 22.1 1.0 1 0 0 1 1 1 0 Macoilin family HCO3_cotransp PF00955.21 ETO21412.1 - 9.5 4.9 9.6 11 4.6 9.6 1.2 1 0 0 1 1 1 0 HCO3- transporter family Pkinase PF00069.25 ETO21413.1 - 1.9e-42 145.5 0.1 3.1e-42 144.8 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21413.1 - 7.1e-20 71.4 0.0 1.2e-19 70.6 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO21413.1 - 0.021 14.2 0.7 0.037 13.4 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO21413.1 - 0.052 12.5 0.0 0.094 11.6 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO21413.1 - 0.073 11.8 0.0 0.073 11.8 0.0 2.2 2 1 0 2 2 2 0 Fungal protein kinase ALS2CR11 PF15729.5 ETO21413.1 - 2.3 7.3 6.2 0.64 9.1 3.2 1.6 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 candidate 11 TFIIA PF03153.13 ETO21413.1 - 7.3 6.5 16.8 9.1 6.1 16.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF2512 PF10710.9 ETO21415.1 - 0.028 14.1 2.2 0.028 14.1 2.2 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2512) ATP-synt_E PF05680.12 ETO21415.1 - 0.083 13.2 0.0 0.13 12.6 0.0 1.2 1 0 0 1 1 1 0 ATP synthase E chain DUF2070 PF09843.9 ETO21415.1 - 0.13 10.6 13.5 0.015 13.7 9.6 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) CENP-F_leu_zip PF10473.9 ETO21416.1 - 7.2e-06 26.1 8.2 7.2e-06 26.1 8.2 2.1 1 1 1 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Cast PF10174.9 ETO21416.1 - 0.00026 19.4 7.8 0.00036 18.9 7.8 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone DUF4407 PF14362.6 ETO21416.1 - 0.00046 19.6 1.0 0.00075 18.9 1.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4407) CENP-Q PF13094.6 ETO21416.1 - 0.024 14.9 1.1 0.024 14.9 1.1 2.0 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DnaGprimase_HBD PF16730.5 ETO21416.1 - 0.039 14.0 3.2 0.079 13.0 3.2 1.5 1 0 0 1 1 1 0 DnaG-primase C-terminal, helicase-binding domain PKcGMP_CC PF16808.5 ETO21416.1 - 0.058 13.2 2.9 5.9 6.8 0.1 2.8 2 1 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase BRE1 PF08647.11 ETO21416.1 - 0.059 13.4 10.9 0.3 11.2 2.3 2.6 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase SPATA1_C PF15743.5 ETO21416.1 - 0.079 13.0 9.6 0.16 12.0 9.6 1.6 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus DUF5320 PF17253.2 ETO21416.1 - 0.13 13.3 1.0 9.8 7.3 0.1 2.7 1 1 1 2 2 2 0 Family of unknown function (DUF5320) APG6_N PF17675.1 ETO21416.1 - 0.44 11.1 12.7 0.8 10.2 11.7 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region NPV_P10 PF05531.12 ETO21416.1 - 0.46 11.0 9.0 14 6.2 5.4 3.1 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF4140 PF13600.6 ETO21416.1 - 0.56 10.7 9.7 1.9 9.0 1.7 3.1 1 1 2 3 3 3 0 N-terminal domain of unknown function (DUF4140) Exonuc_VII_L PF02601.15 ETO21416.1 - 0.61 9.6 7.4 0.92 9.0 7.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CENP-H PF05837.12 ETO21416.1 - 0.63 10.5 12.2 0.78 10.2 5.1 2.4 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Spc7 PF08317.11 ETO21416.1 - 0.68 8.8 12.9 1.3 7.8 12.9 1.4 1 0 0 1 1 1 0 Spc7 kinetochore protein Bcr-Abl_Oligo PF09036.10 ETO21416.1 - 0.75 9.8 3.0 12 6.0 0.1 2.8 3 0 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain UPF0242 PF06785.11 ETO21416.1 - 0.78 9.8 16.0 0.099 12.7 6.1 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Cortex-I_coil PF09304.10 ETO21416.1 - 0.93 9.7 7.4 0.2 11.9 2.2 2.1 1 1 1 2 2 2 0 Cortexillin I, coiled coil ATG16 PF08614.11 ETO21416.1 - 1.1 9.5 15.3 3.3 7.9 15.3 1.8 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Jnk-SapK_ap_N PF09744.9 ETO21416.1 - 2.1 8.5 15.7 0.87 9.8 12.1 2.2 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Snapin_Pallidin PF14712.6 ETO21416.1 - 4.1 7.9 12.3 4.8 7.7 3.1 2.5 2 0 0 2 2 2 0 Snapin/Pallidin Herpes_LAMP2 PF06126.11 ETO21416.1 - 4.5 5.8 8.6 2.4 6.7 0.5 2.6 2 1 0 2 2 2 0 Herpesvirus Latent membrane protein 2 Fib_alpha PF08702.10 ETO21416.1 - 5 7.3 13.0 2.4 8.3 5.6 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family THOC7 PF05615.13 ETO21416.1 - 6.7 7.0 14.3 0.81 10.0 3.0 2.9 1 1 2 3 3 3 0 Tho complex subunit 7 CCDC53 PF10152.9 ETO21417.1 - 0.012 16.0 0.0 0.015 15.7 0.0 1.3 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Ribosomal_60s PF00428.19 ETO21417.1 - 0.063 13.9 4.4 0.12 13.0 3.6 1.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein WRNPLPNID PF15017.6 ETO21417.1 - 0.45 11.4 4.6 1.3 10.0 4.6 1.7 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box Sporozoite_P67 PF05642.11 ETO21417.1 - 4.2 5.3 5.3 4.1 5.4 0.1 2.0 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Nuc_sug_transp PF04142.15 ETO21418.1 - 2e-34 119.2 12.1 1.4e-26 93.4 8.0 2.1 2 0 0 2 2 2 2 Nucleotide-sugar transporter UAA PF08449.11 ETO21418.1 - 3.6e-05 23.1 12.5 9.1e-05 21.8 8.1 2.8 1 1 0 2 2 2 1 UAA transporter family EamA PF00892.20 ETO21418.1 - 0.011 15.9 0.3 0.011 15.9 0.3 3.8 4 1 0 4 4 4 0 EamA-like transporter family DUF4131 PF13567.6 ETO21418.1 - 0.063 12.9 0.1 0.063 12.9 0.1 3.7 3 1 1 4 4 4 0 Domain of unknown function (DUF4131) Nop25 PF09805.9 ETO21419.1 - 0.0027 18.2 20.4 0.0033 17.9 20.4 1.1 1 0 0 1 1 1 1 Nucleolar protein 12 (25kDa) V_ATPase_I PF01496.19 ETO21419.1 - 0.0068 14.4 12.7 0.0079 14.2 12.7 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family CNDH2_C PF16858.5 ETO21419.1 - 0.013 15.4 12.4 0.014 15.3 12.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Zip PF02535.22 ETO21419.1 - 0.02 14.1 11.3 0.026 13.7 11.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter BSP_II PF05432.11 ETO21419.1 - 0.023 14.4 17.7 0.025 14.3 17.7 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Hydin_ADK PF17213.3 ETO21419.1 - 0.032 14.5 6.9 0.042 14.1 6.9 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PEPcase PF00311.17 ETO21419.1 - 0.047 11.8 8.0 0.056 11.5 8.0 1.0 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Miga PF10265.9 ETO21419.1 - 0.051 12.6 12.1 0.055 12.4 12.1 1.0 1 0 0 1 1 1 0 Mitoguardin ArsP_1 PF03773.13 ETO21419.1 - 0.069 12.3 2.6 0.087 12.0 2.6 1.1 1 0 0 1 1 1 0 Predicted permease Neur_chan_memb PF02932.16 ETO21419.1 - 0.12 12.4 13.7 0.13 12.2 13.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region LapA_dom PF06305.11 ETO21419.1 - 0.15 11.9 5.6 0.16 11.8 3.8 1.8 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain Presenilin PF01080.17 ETO21419.1 - 0.15 10.8 18.4 0.18 10.5 18.4 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO21419.1 - 0.2 10.7 19.2 0.2 10.6 19.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 FAM60A PF15396.6 ETO21419.1 - 0.21 11.6 20.3 0.26 11.3 20.3 1.3 1 0 0 1 1 1 0 Protein Family FAM60A CLN3 PF02487.17 ETO21419.1 - 0.24 10.4 5.6 0.3 10.1 5.6 1.3 1 0 0 1 1 1 0 CLN3 protein AAA_13 PF13166.6 ETO21419.1 - 0.31 9.7 19.6 0.37 9.4 19.6 1.0 1 0 0 1 1 1 0 AAA domain DUF4746 PF15928.5 ETO21419.1 - 0.32 10.4 9.2 0.39 10.1 9.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PIEZO PF15917.5 ETO21419.1 - 0.49 9.8 14.0 0.6 9.6 14.0 1.2 1 0 0 1 1 1 0 Piezo DUF2076 PF09849.9 ETO21419.1 - 0.71 9.9 19.1 0.97 9.4 19.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Serinc PF03348.15 ETO21419.1 - 0.79 8.6 7.2 1.2 8.0 7.2 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) ALMT PF11744.8 ETO21419.1 - 0.92 8.3 20.9 1.1 8.0 20.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Rgp1 PF08737.10 ETO21419.1 - 0.95 8.6 15.8 1.1 8.4 15.8 1.1 1 0 0 1 1 1 0 Rgp1 PNISR PF15996.5 ETO21419.1 - 1.1 9.6 22.5 1.4 9.2 22.5 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF5427 PF10310.9 ETO21419.1 - 1.1 8.1 19.4 1.4 7.8 19.4 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Mem_trans PF03547.18 ETO21419.1 - 1.2 7.5 6.9 1.4 7.2 6.9 1.2 1 0 0 1 1 1 0 Membrane transport protein SID-1_RNA_chan PF13965.6 ETO21419.1 - 1.2 7.5 12.6 1.4 7.2 12.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Dapper PF15268.6 ETO21419.1 - 1.3 7.8 18.5 1.5 7.6 18.5 1.0 1 0 0 1 1 1 0 Dapper Cons_hypoth698 PF03601.14 ETO21419.1 - 1.5 7.6 3.9 2 7.2 3.9 1.1 1 0 0 1 1 1 0 Conserved hypothetical protein 698 NPR3 PF03666.13 ETO21419.1 - 1.9 7.2 25.7 2.4 6.9 25.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Membralin PF09746.9 ETO21419.1 - 2.1 7.3 10.4 2.5 7.1 10.4 1.3 1 0 0 1 1 1 0 Tumour-associated protein MFS_2 PF13347.6 ETO21419.1 - 2.2 6.7 4.1 2.8 6.4 4.1 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein DDHD PF02862.17 ETO21419.1 - 2.5 8.2 12.9 3.2 7.9 12.9 1.2 1 0 0 1 1 1 0 DDHD domain EphA2_TM PF14575.6 ETO21419.1 - 2.6 9.0 13.5 41 5.1 13.5 2.6 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain XRN_M PF17846.1 ETO21419.1 - 3 6.7 20.2 3.7 6.4 20.2 1.0 1 0 0 1 1 1 0 Xrn1 helical domain 7TM_GPCR_Srv PF10323.9 ETO21419.1 - 3.5 6.9 8.6 1.5 8.1 6.3 1.6 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv DUF1387 PF07139.11 ETO21419.1 - 3.6 7.2 28.9 4.5 6.9 28.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) GREB1 PF15782.5 ETO21419.1 - 3.7 4.6 13.6 4.1 4.4 13.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4407 PF14362.6 ETO21419.1 - 3.7 6.8 5.8 4.4 6.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MID_MedPIWI PF18296.1 ETO21419.1 - 4.3 7.0 13.7 5.5 6.7 13.7 1.2 1 0 0 1 1 1 0 MID domain of medPIWI PPL5 PF18168.1 ETO21419.1 - 4.6 6.4 15.5 6.9 5.9 15.5 1.4 1 0 0 1 1 1 0 Prim-pol family 5 DUF4175 PF13779.6 ETO21419.1 - 4.8 5.0 14.8 5.4 4.8 14.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4228 PF14009.6 ETO21419.1 - 4.8 7.5 16.8 13 6.1 16.8 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4228) DUF3684 PF12449.8 ETO21419.1 - 4.9 4.8 13.2 5.4 4.7 13.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3684) HCO3_cotransp PF00955.21 ETO21419.1 - 4.9 5.9 10.2 5.9 5.6 10.2 1.1 1 0 0 1 1 1 0 HCO3- transporter family PAP1 PF08601.10 ETO21419.1 - 6.1 6.5 22.8 7.7 6.1 22.8 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 DUF3807 PF12720.7 ETO21419.1 - 7.5 6.8 27.0 11 6.3 27.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) O-antigen_lig PF13425.6 ETO21419.1 - 7.6 5.2 17.1 13 4.5 17.1 1.4 1 1 0 1 1 1 0 O-antigen ligase like membrane protein FAM176 PF14851.6 ETO21419.1 - 7.9 6.1 18.7 5.6 6.6 2.2 2.2 1 1 1 2 2 2 0 FAM176 family Macoilin PF09726.9 ETO21419.1 - 8.2 4.8 24.6 9.6 4.6 24.6 1.0 1 0 0 1 1 1 0 Macoilin family DUF936 PF06075.12 ETO21419.1 - 8.8 5.1 22.0 9.6 5.0 22.0 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) FANC_SAP PF18081.1 ETO21420.1 - 0.0018 18.4 0.1 0.005 17.0 0.1 1.6 1 1 0 1 1 1 1 Fanconi anemia-associated nuclease SAP domain Rad4 PF03835.15 ETO21421.1 - 0.1 12.2 0.8 0.17 11.5 0.2 1.7 2 0 0 2 2 2 0 Rad4 transglutaminase-like domain FA_desaturase PF00487.24 ETO21421.1 - 0.12 12.2 2.0 0.16 11.8 2.0 1.1 1 0 0 1 1 1 0 Fatty acid desaturase FtsH_ext PF06480.15 ETO21421.1 - 1.2 9.5 3.2 2.6 8.4 3.2 1.6 1 0 0 1 1 1 0 FtsH Extracellular WD40 PF00400.32 ETO21422.1 - 8.7e-69 225.8 20.3 3.8e-10 40.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21422.1 - 4.2e-22 78.2 2.8 0.0026 18.0 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21422.1 - 4e-19 68.8 2.5 0.022 13.7 0.0 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO21422.1 - 7.7e-13 48.8 3.1 5.4e-08 32.9 0.2 3.8 1 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO21422.1 - 1.5e-09 37.5 10.0 0.44 10.6 0.0 7.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO21422.1 - 1e-06 27.7 6.4 0.17 10.5 0.0 5.6 3 2 1 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO21422.1 - 4.9e-06 25.3 0.2 0.0009 17.9 0.0 2.8 1 1 2 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO21422.1 - 8.3e-06 25.3 3.3 0.02 14.2 0.1 3.8 1 1 3 4 4 4 1 WD40-like domain Utp8 PF10395.9 ETO21422.1 - 5.3e-05 22.0 1.2 0.0031 16.1 0.2 3.1 1 1 2 3 3 3 1 Utp8 family DUF1258 PF06869.12 ETO21422.1 - 0.00046 19.8 1.0 0.041 13.4 0.1 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1258) HARP PF07443.13 ETO21422.1 - 0.0023 17.6 0.4 7.5 6.3 0.0 4.2 5 0 0 5 5 4 1 HepA-related protein (HARP) Nbas_N PF15492.6 ETO21422.1 - 0.0028 17.0 2.8 4.2 6.6 0.1 4.4 1 1 4 6 6 6 1 Neuroblastoma-amplified sequence, N terminal DUF5449 PF17528.2 ETO21422.1 - 0.01 15.6 0.9 6.4 6.5 0.1 3.0 1 1 0 2 2 2 0 Family of unknown function (DUF5449) DPPIV_N PF00930.21 ETO21422.1 - 0.013 14.2 0.2 1.5 7.5 0.1 3.2 2 1 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Colicin_Ia PF11504.8 ETO21422.1 - 0.034 14.3 0.4 50 4.1 0.0 4.6 5 0 0 5 5 5 0 Colicin Ia Coat_X PF07552.11 ETO21422.1 - 0.078 12.8 0.2 10 6.0 0.0 2.6 2 0 0 2 2 2 0 Spore Coat Protein X and V domain FAM167 PF11652.8 ETO21422.1 - 0.14 12.7 0.0 15 6.1 0.0 2.7 2 1 1 3 3 3 0 FAM167 Proteasome_A_N PF10584.9 ETO21422.1 - 0.47 10.2 10.8 51 3.7 0.0 5.4 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Acylphosphatase PF00708.18 ETO21424.1 - 6.1e-14 52.2 0.5 1e-13 51.4 0.5 1.5 1 1 0 1 1 1 1 Acylphosphatase PP2C PF00481.21 ETO21425.1 - 1.5e-05 24.8 3.2 5.3e-05 23.0 0.0 2.2 2 0 0 2 2 2 1 Protein phosphatase 2C CDC45 PF02724.14 ETO21425.1 - 0.00085 17.8 2.0 0.00093 17.6 2.0 1.1 1 0 0 1 1 1 1 CDC45-like protein DDHD PF02862.17 ETO21425.1 - 0.024 14.8 0.6 0.027 14.6 0.6 1.2 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.19 ETO21425.1 - 0.051 13.3 4.2 1.7 8.3 4.6 2.2 2 0 0 2 2 2 0 Connexin DUF913 PF06025.12 ETO21425.1 - 0.058 12.4 3.5 0.078 11.9 3.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM60A PF15396.6 ETO21425.1 - 0.19 11.7 6.3 0.16 11.9 4.8 1.6 2 0 0 2 2 2 0 Protein Family FAM60A CobT PF06213.12 ETO21425.1 - 0.66 9.3 13.4 0.8 9.0 11.3 1.8 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT CPSF100_C PF13299.6 ETO21425.1 - 0.91 9.7 7.8 1.8 8.8 7.8 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal AIF_C PF14721.6 ETO21425.1 - 1.1 9.6 9.1 2.4 8.5 9.1 1.5 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term V_ATPase_I PF01496.19 ETO21425.1 - 1.5 6.7 7.6 2.1 6.2 7.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Vfa1 PF08432.10 ETO21425.1 - 1.6 9.0 16.3 0.23 11.8 12.3 1.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF4820 PF16091.5 ETO21425.1 - 1.9 7.8 7.8 2.9 7.2 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EIIBC-GUT_N PF03612.14 ETO21425.1 - 2.1 8.0 4.3 3.9 7.2 4.3 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DNA_pol_phi PF04931.13 ETO21425.1 - 3.5 5.6 19.6 5 5.1 19.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi NPR3 PF03666.13 ETO21425.1 - 8.6 5.0 15.9 12 4.5 15.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PARM PF17061.5 ETO21426.1 - 0.4 10.8 9.6 0.11 12.6 6.3 1.6 1 1 0 1 1 1 0 PARM Vac7 PF12751.7 ETO21429.1 - 0.59 9.5 14.9 0.7 9.3 14.9 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 Menin PF05053.13 ETO21429.1 - 4.7 5.4 13.7 5 5.4 13.7 1.1 1 0 0 1 1 1 0 Menin Defensin_big PF14862.6 ETO21430.1 - 0.1 13.0 1.3 0.17 12.2 0.4 1.8 2 0 0 2 2 2 0 Big defensin SET PF00856.28 ETO21431.1 - 8.2e-12 45.8 0.0 5.9e-11 43.0 0.0 2.4 2 1 0 2 2 2 1 SET domain OrfA PF17495.2 ETO21431.1 - 0.06 13.5 1.0 0.14 12.3 1.0 1.6 1 0 0 1 1 1 0 Vpr-like OrfA SDP_N PF12278.8 ETO21431.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Sex determination protein N terminal DUF4090 PF13319.6 ETO21431.1 - 0.15 12.3 0.2 0.43 10.9 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4090) Transpos_assoc PF13963.6 ETO21431.1 - 0.26 11.6 1.7 0.93 9.9 0.3 2.4 2 0 0 2 2 2 0 Transposase-associated domain IPK PF03770.16 ETO21432.1 - 7.4e-37 127.1 1.9 2e-36 125.7 1.9 1.7 1 1 0 1 1 1 1 Inositol polyphosphate kinase RRN3 PF05327.11 ETO21432.1 - 6 5.3 11.9 13 4.2 11.9 1.7 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 GGDEF PF00990.21 ETO21433.1 - 0.0092 15.7 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 Diguanylate cyclase, GGDEF domain SUR7 PF06687.12 ETO21434.1 - 0.0014 18.3 0.7 0.0019 17.9 0.7 1.2 1 0 0 1 1 1 1 SUR7/PalI family HOCHOB PF17943.1 ETO21434.1 - 0.55 11.0 5.0 0.14 12.8 2.0 1.5 2 0 0 2 2 2 0 Homeobox-cysteine loop-homeobox HSA PF07529.13 ETO21437.1 - 0.18 12.2 2.1 9.6 6.6 0.6 2.5 2 0 0 2 2 2 0 HSA USP7_ICP0_bdg PF12436.8 ETO21441.1 - 5.8e-22 78.2 0.3 7.1e-22 77.9 0.3 1.1 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 Ion_trans PF00520.31 ETO21443.1 - 1.9e-15 56.8 9.7 2.6e-15 56.3 9.7 1.1 1 0 0 1 1 1 1 Ion transport protein DUF2730 PF10805.8 ETO21443.1 - 0.17 12.0 1.5 0.33 11.1 1.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) Ribonuc_L-PSP PF01042.21 ETO21446.1 - 1.9e-05 24.7 0.1 0.0001 22.3 0.0 2.2 3 0 0 3 3 3 1 Endoribonuclease L-PSP Cwf_Cwc_15 PF04889.12 ETO21446.1 - 0.0013 18.6 6.7 0.0017 18.2 6.7 1.1 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein ARD PF03079.14 ETO21446.1 - 0.0028 17.9 1.8 0.0077 16.4 0.0 2.2 2 0 0 2 2 2 1 ARD/ARD' family NOA36 PF06524.12 ETO21446.1 - 0.0059 16.0 6.3 0.0078 15.6 6.3 1.2 1 0 0 1 1 1 1 NOA36 protein DUF2457 PF10446.9 ETO21446.1 - 0.015 14.4 9.6 0.02 14.0 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ETO21446.1 - 0.047 14.0 6.8 0.095 13.1 6.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RXT2_N PF08595.11 ETO21446.1 - 0.1 12.6 6.3 0.16 12.0 6.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 ETO21446.1 - 0.15 11.7 7.1 0.27 10.9 7.1 1.3 1 0 0 1 1 1 0 FAM176 family CENP-B_dimeris PF09026.10 ETO21446.1 - 0.18 12.2 10.3 0.31 11.5 10.3 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 ETO21446.1 - 0.21 11.4 11.3 0.33 10.7 11.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RFXA_RFXANK_bdg PF15289.6 ETO21446.1 - 0.24 11.7 3.4 0.48 10.8 3.4 1.5 1 0 0 1 1 1 0 Regulatory factor X-associated C-terminal binding domain Pes-10 PF07149.11 ETO21446.1 - 0.26 10.3 1.9 0.33 10.0 1.9 1.1 1 0 0 1 1 1 0 Pes-10 DUF4611 PF15387.6 ETO21446.1 - 0.46 10.7 9.1 0.98 9.7 9.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 ETO21446.1 - 0.78 7.8 6.5 1 7.3 6.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3245 PF11595.8 ETO21446.1 - 5.5 7.4 14.8 10 6.6 14.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) DUF913 PF06025.12 ETO21446.1 - 7.9 5.3 7.3 5.9 5.8 5.0 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Pinin_SDK_N PF04697.13 ETO21446.1 - 8.9 7.0 10.7 1.3e+02 3.2 10.7 2.3 1 1 0 1 1 1 0 pinin/SDK conserved region PHM7_ext PF12621.8 ETO21448.1 - 0.011 15.8 1.9 0.011 15.8 1.9 2.6 1 1 2 3 3 3 0 Extracellular tail, of 10TM putative phosphate transporter zf_C2HC_14 PF18574.1 ETO21448.1 - 0.026 14.3 3.0 0.13 12.0 0.3 2.5 2 0 0 2 2 2 0 C2HC Zing finger domain zinc_ribbon_9 PF14369.6 ETO21448.1 - 0.27 11.5 3.1 0.44 10.9 0.2 2.6 2 1 0 2 2 2 0 zinc-ribbon Pkinase PF00069.25 ETO21449.1 - 1.1e-25 90.5 0.0 2.3e-25 89.5 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21449.1 - 6.8e-14 51.8 0.0 1.5e-13 50.7 0.0 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO21449.1 - 3.4e-05 23.3 0.2 0.00089 18.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Menin PF05053.13 ETO21451.1 - 0.38 9.1 4.2 0.42 8.9 4.2 1.1 1 0 0 1 1 1 0 Menin UPF0239 PF06783.11 ETO21452.1 - 0.41 10.9 0.0 0.41 10.9 0.0 4.5 4 2 0 4 4 4 0 Uncharacterised protein family (UPF0239) PTPRCAP PF15713.5 ETO21452.1 - 1.2 9.5 23.2 0.17 12.1 6.3 3.4 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated BTB PF00651.31 ETO21453.1 - 5.9e-10 39.4 1.7 0.00011 22.4 0.1 2.7 3 0 0 3 3 3 2 BTB/POZ domain DUF4373 PF14297.6 ETO21453.1 - 0.006 17.3 1.1 0.11 13.3 0.2 2.6 2 1 0 2 2 2 1 Domain of unknown function (DUF4373) NAD_binding_8 PF13450.6 ETO21454.1 - 2.3e-08 34.2 0.0 8.7e-08 32.3 0.0 2.1 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETO21454.1 - 4e-06 26.3 0.2 9.1e-06 25.1 0.2 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETO21454.1 - 6.7e-06 25.4 0.1 9.8e-06 24.9 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ETO21454.1 - 5.7e-05 22.0 0.2 8.9e-05 21.4 0.2 1.2 1 0 0 1 1 1 1 HI0933-like protein FAD_binding_3 PF01494.19 ETO21454.1 - 0.00036 19.9 0.1 0.00049 19.4 0.1 1.2 1 0 0 1 1 1 1 FAD binding domain Pyr_redox PF00070.27 ETO21454.1 - 0.0011 19.4 0.0 0.0059 17.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETO21454.1 - 0.0012 18.0 0.0 0.0015 17.7 0.0 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_oxidored PF12831.7 ETO21454.1 - 0.0013 18.2 0.1 0.002 17.5 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_3 PF13738.6 ETO21454.1 - 0.022 14.0 0.0 0.038 13.2 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETO21454.1 - 0.029 13.6 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Thi4 family DAO PF01266.24 ETO21454.1 - 0.13 11.8 0.1 0.22 11.0 0.1 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase GMC_oxred_N PF00732.19 ETO21455.1 - 4.1e-05 23.1 0.1 6e-05 22.6 0.1 1.1 1 0 0 1 1 1 1 GMC oxidoreductase FAD_binding_2 PF00890.24 ETO21455.1 - 5.9e-05 22.3 0.0 0.0045 16.1 0.0 2.7 2 1 1 3 3 3 1 FAD binding domain Amino_oxidase PF01593.24 ETO21455.1 - 0.002 17.5 0.0 0.43 9.8 0.0 2.3 2 0 0 2 2 2 2 Flavin containing amine oxidoreductase DAO PF01266.24 ETO21455.1 - 0.023 14.3 0.0 0.067 12.8 0.0 1.7 3 0 0 3 3 3 0 FAD dependent oxidoreductase TGT PF01702.18 ETO21456.1 - 1.7e-35 122.8 3.2 2e-28 99.6 0.1 2.1 2 0 0 2 2 2 2 Queuine tRNA-ribosyltransferase DUF1892 PF08987.10 ETO21456.1 - 0.056 13.6 0.1 0.46 10.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1892) DUF3169 PF11368.8 ETO21459.1 - 0.0026 17.3 0.2 0.0026 17.3 0.2 3.1 3 1 0 3 3 3 1 Protein of unknown function (DUF3169) DUF3566 PF12089.8 ETO21459.1 - 5.6 7.4 7.7 0.27 11.6 0.7 2.3 2 1 0 2 2 2 0 Transmembrane domain of unknown function (DUF3566) NIF PF03031.18 ETO21460.1 - 4.3e-57 192.3 0.2 6.3e-57 191.7 0.2 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF3439 PF11921.8 ETO21461.1 - 0.8 9.7 8.3 1.7 8.7 8.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO21461.1 - 6.3 6.8 15.4 13 5.7 15.4 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein RSN1_TM PF13967.6 ETO21462.1 - 0.044 13.5 0.7 0.077 12.7 0.7 1.3 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport ETRAMP PF09716.10 ETO21462.1 - 0.07 13.2 4.0 0.16 12.1 4.0 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Presenilin PF01080.17 ETO21463.1 - 1.6 7.4 4.1 1.8 7.3 4.1 1.2 1 0 0 1 1 1 0 Presenilin Aldedh PF00171.22 ETO21464.1 - 1.2e-34 119.6 0.1 1.4e-34 119.5 0.1 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family LuxC PF05893.14 ETO21464.1 - 0.069 12.2 0.0 0.084 11.9 0.0 1.1 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) RRM_1 PF00076.22 ETO21465.1 - 0.00081 19.2 0.0 0.0021 17.8 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WD40 PF00400.32 ETO21466.1 - 7e-28 96.3 21.0 2.3e-09 37.7 0.3 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21466.1 - 7.3e-08 32.6 0.5 0.47 10.8 0.1 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF5046 PF16465.5 ETO21466.1 - 0.00035 20.1 0.2 0.16 11.4 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) DUF2635 PF10948.8 ETO21467.1 - 0.046 13.4 0.1 0.084 12.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2635) Peptidase_M10 PF00413.24 ETO21470.1 - 0.17 11.7 6.7 0.14 12.0 5.0 1.6 1 1 1 2 2 2 0 Matrixin Exonuc_VII_L PF02601.15 ETO21470.1 - 0.59 9.6 15.3 0.69 9.4 15.3 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Cupredoxin_1 PF13473.6 ETO21470.1 - 0.87 9.7 6.9 1.7 8.8 6.9 1.7 1 1 0 1 1 1 0 Cupredoxin-like domain Fib_alpha PF08702.10 ETO21470.1 - 1.3 9.2 18.0 1.9 8.7 18.0 1.2 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family ADIP PF11559.8 ETO21470.1 - 3.6 7.6 29.7 1.5 8.9 9.9 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding DDHD PF02862.17 ETO21470.1 - 3.7 7.7 11.1 4.9 7.2 11.1 1.2 1 0 0 1 1 1 0 DDHD domain FTCD_C PF04961.12 ETO21470.1 - 6 6.6 10.4 0.88 9.3 1.8 2.1 2 0 0 2 2 2 0 Formiminotransferase-cyclodeaminase Pkinase PF00069.25 ETO21471.1 - 3.2e-17 62.8 2.8 1.9e-08 34.0 1.0 3.3 2 1 1 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21471.1 - 1.8e-10 40.6 1.6 1.9e-09 37.2 0.9 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO21471.1 - 6.4e-05 22.4 1.0 0.00011 21.6 0.3 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO21471.1 - 0.0091 15.3 0.0 0.016 14.6 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pro-kuma_activ PF09286.11 ETO21471.1 - 0.018 15.3 0.1 0.042 14.2 0.1 1.7 1 0 0 1 1 1 0 Pro-kumamolisin, activation domain APH PF01636.23 ETO21471.1 - 0.034 14.1 0.3 0.066 13.1 0.3 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ETO21471.1 - 0.045 13.3 0.0 0.13 11.8 0.0 1.7 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL EF-hand_1 PF00036.32 ETO21472.1 - 8.3e-06 25.0 0.5 0.0017 17.8 0.0 2.8 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO21472.1 - 3.8e-05 24.0 2.1 0.0023 18.4 0.3 2.9 2 2 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO21472.1 - 0.00057 19.7 0.3 0.0035 17.2 0.3 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO21472.1 - 0.0047 16.4 0.4 0.018 14.5 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO21472.1 - 0.0092 15.8 0.5 0.31 11.1 0.0 3.2 3 0 0 3 3 2 1 EF-hand domain KASH_CCD PF14662.6 ETO21472.1 - 0.051 13.4 40.2 0.06 13.2 18.2 2.4 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF2968 PF11180.8 ETO21472.1 - 0.062 12.9 30.7 0.66 9.6 11.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) ATP-synt_8 PF00895.20 ETO21472.1 - 0.068 13.6 1.2 0.068 13.6 1.2 2.1 2 0 0 2 2 1 0 ATP synthase protein 8 GAS PF13851.6 ETO21472.1 - 0.11 11.8 34.9 0.077 12.3 16.2 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ETO21472.1 - 0.28 11.7 37.4 1.2 9.7 17.5 2.6 1 1 1 2 2 2 0 Apg6 coiled-coil region Filament PF00038.21 ETO21472.1 - 0.28 10.7 31.2 0.25 10.9 17.9 2.5 1 1 2 3 3 3 0 Intermediate filament protein ADIP PF11559.8 ETO21472.1 - 0.38 10.8 37.5 0.14 12.3 15.0 2.7 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding CALCOCO1 PF07888.11 ETO21472.1 - 0.39 9.5 33.1 0.6 8.9 33.1 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like LMBR1 PF04791.16 ETO21472.1 - 0.68 8.8 10.2 0.87 8.4 10.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-F_leu_zip PF10473.9 ETO21472.1 - 0.85 9.6 36.8 2.4 8.2 25.7 2.5 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4201 PF13870.6 ETO21472.1 - 1.5 8.5 40.5 0.12 12.1 4.6 3.9 2 1 0 3 3 2 0 Domain of unknown function (DUF4201) ATG16 PF08614.11 ETO21472.1 - 2.1 8.5 41.3 8.8 6.5 25.4 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 ETO21472.1 - 2.3 8.3 33.3 7.5 6.6 9.9 3.0 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein HAUS-augmin3 PF14932.6 ETO21472.1 - 2.6 7.5 34.5 2.5 7.6 14.2 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 DUF724 PF05266.14 ETO21472.1 - 3.2 7.5 25.5 1.9 8.3 12.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Imm7 PF15585.6 ETO21472.1 - 3.4 8.0 8.9 1.2 9.4 1.0 3.4 2 1 2 4 4 4 0 Immunity protein 7 DUF4795 PF16043.5 ETO21472.1 - 3.6 7.1 29.2 0.62 9.6 6.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) DUF3450 PF11932.8 ETO21472.1 - 5.5 6.2 34.6 0.87 8.8 16.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF812 PF05667.11 ETO21472.1 - 6.6 5.5 31.0 0.4 9.5 11.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) YabA PF06156.13 ETO21472.1 - 7.8 7.2 30.2 6.7 7.4 9.0 3.8 1 1 2 3 3 3 0 Initiation control protein YabA Fez1 PF06818.15 ETO21472.1 - 8.3 6.8 32.6 50 4.3 13.8 2.4 1 1 1 2 2 2 0 Fez1 PI31_Prot_N PF11566.8 ETO21473.1 - 0.011 15.5 0.4 0.021 14.6 0.4 1.4 1 0 0 1 1 1 0 PI31 proteasome regulator N-terminal Auxin_canalis PF05703.11 ETO21473.1 - 0.018 15.0 3.7 0.023 14.7 3.7 1.1 1 0 0 1 1 1 0 Auxin canalisation Spo7 PF03907.13 ETO21473.1 - 0.036 13.5 0.6 0.052 13.0 0.6 1.2 1 0 0 1 1 1 0 Spo7-like protein SNAD3 PF18749.1 ETO21473.1 - 0.31 10.2 7.8 0.4 9.8 7.8 1.1 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 3 AAA_23 PF13476.6 ETO21473.1 - 1.5 9.3 15.6 1.9 9.0 15.6 1.1 1 0 0 1 1 1 0 AAA domain EP400_N PF15790.5 ETO21473.1 - 1.8 7.3 6.4 2.1 7.1 6.4 1.1 1 0 0 1 1 1 0 E1A-binding protein p400, N-terminal Exonuc_VII_L PF02601.15 ETO21473.1 - 4.5 6.8 9.5 5.3 6.5 9.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit WD40 PF00400.32 ETO21474.1 - 5.2e-05 23.9 0.1 0.0016 19.3 0.1 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21474.1 - 0.023 15.0 0.0 1.3 9.4 0.0 2.6 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Synaptobrevin PF00957.21 ETO21475.1 - 0.18 11.6 0.1 0.18 11.6 0.1 2.2 2 0 0 2 2 2 0 Synaptobrevin DUF1270 PF06900.11 ETO21477.1 - 0.051 14.0 0.6 0.15 12.5 0.6 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1270) Zip PF02535.22 ETO21477.1 - 0.27 10.4 0.0 0.27 10.4 0.0 2.5 3 0 0 3 3 3 0 ZIP Zinc transporter Apolipoprotein PF01442.18 ETO21479.1 - 0.079 12.8 13.6 0.27 11.1 10.4 2.2 2 0 0 2 2 2 0 Apolipoprotein A1/A4/E domain TSC22 PF01166.18 ETO21479.1 - 0.11 12.8 0.3 0.11 12.8 0.3 4.1 2 1 2 4 4 4 0 TSC-22/dip/bun family WD40_alt PF14077.6 ETO21479.1 - 0.22 11.4 3.2 14 5.6 0.2 2.9 2 0 0 2 2 2 0 Alternative WD40 repeat motif DUF4618 PF15397.6 ETO21479.1 - 0.26 10.7 26.8 0.15 11.4 19.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4618) DUF883 PF05957.13 ETO21479.1 - 0.33 11.6 7.5 0.4 11.3 4.0 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF883) DUF1515 PF07439.11 ETO21479.1 - 0.33 11.0 8.7 0.62 10.1 1.6 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) Gp-FAR-1 PF05823.12 ETO21479.1 - 0.35 11.2 16.6 0.45 10.9 0.1 2.7 2 1 0 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) CdvA PF18822.1 ETO21479.1 - 0.44 10.4 26.2 0.56 10.0 10.8 3.4 2 1 1 3 3 3 0 CdvA-like coiled-coil domain DUF4248 PF14053.6 ETO21479.1 - 0.66 10.0 3.9 3 7.9 0.3 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4248) Hemerythrin PF01814.23 ETO21479.1 - 0.79 10.4 5.3 4.5 7.9 0.6 2.9 2 1 1 3 3 3 0 Hemerythrin HHE cation binding domain MCC-bdg_PDZ PF10506.9 ETO21479.1 - 0.88 9.6 16.6 1.1 9.3 0.4 3.5 2 1 2 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome bZIP_1 PF00170.21 ETO21479.1 - 1 9.5 30.6 0.12 12.5 6.5 4.5 3 2 1 4 4 4 0 bZIP transcription factor DivIC PF04977.15 ETO21479.1 - 1.2 8.9 20.2 0.52 10.1 5.8 3.4 2 1 0 3 3 3 0 Septum formation initiator DUF4279 PF14106.6 ETO21479.1 - 1.4 9.1 6.5 0.37 11.0 1.2 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4279) Cep57_MT_bd PF06657.13 ETO21479.1 - 1.9 9.0 25.2 0.35 11.3 12.0 3.4 3 2 0 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Mod_r PF07200.13 ETO21479.1 - 2.4 8.2 30.9 0.32 11.1 21.9 2.7 2 1 1 3 3 3 0 Modifier of rudimentary (Mod(r)) protein DUF4175 PF13779.6 ETO21479.1 - 2.7 5.8 23.7 3.7 5.3 23.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF5595 PF18077.1 ETO21479.1 - 3.8 7.7 21.2 7.5 6.7 0.7 4.5 2 1 2 4 4 4 0 Domain of unknown function (DUF5595) TetR_C_24 PF17932.1 ETO21479.1 - 5.1 7.4 5.7 10 6.4 1.1 2.6 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_MLP1_2 PF07926.12 ETO21479.1 - 5.5 7.1 37.9 0.16 12.0 25.8 2.7 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein FolB PF02152.18 ETO21480.1 - 2.3e-23 82.9 0.0 3.2e-23 82.4 0.0 1.2 1 0 0 1 1 1 1 Dihydroneopterin aldolase LysM PF01476.20 ETO21481.1 - 0.0036 17.3 0.0 0.0068 16.4 0.0 1.4 1 0 0 1 1 1 1 LysM domain Apocytochr_F_N PF16639.5 ETO21481.1 - 0.12 12.6 0.1 0.3 11.4 0.0 1.7 2 0 0 2 2 2 0 Apocytochrome F, N-terminal ENTH PF01417.20 ETO21482.1 - 8.8e-24 83.9 0.0 2e-23 82.8 0.0 1.6 1 0 0 1 1 1 1 ENTH domain SDA1 PF05285.12 ETO21482.1 - 0.0019 17.7 22.6 0.0019 17.7 22.6 1.9 2 0 0 2 2 2 1 SDA1 ANTH PF07651.16 ETO21482.1 - 0.021 13.8 0.0 0.021 13.8 0.0 2.0 2 0 0 2 2 2 0 ANTH domain Nop14 PF04147.12 ETO21482.1 - 0.99 7.5 32.5 0.066 11.4 25.0 2.4 3 0 0 3 3 3 0 Nop14-like family Zip PF02535.22 ETO21482.1 - 1.7 7.8 4.1 4.1 6.5 4.1 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter LAP1C PF05609.12 ETO21482.1 - 2.1 7.4 15.3 0.2 10.7 10.3 1.7 1 1 1 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) TFIIF_alpha PF05793.12 ETO21482.1 - 2.5 6.6 35.6 5.2 5.5 35.6 1.5 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Sec62 PF03839.16 ETO21482.1 - 7.5 6.0 11.1 23 4.4 11.1 1.8 1 0 0 1 1 1 0 Translocation protein Sec62 Nop14 PF04147.12 ETO21483.1 - 0.0022 16.3 31.9 0.0043 15.3 31.9 1.5 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 ETO21483.1 - 0.0047 15.3 24.3 0.0071 14.7 24.3 1.2 1 0 0 1 1 1 1 CDC45-like protein DUF2457 PF10446.9 ETO21483.1 - 0.13 11.4 28.7 0.35 10.0 28.7 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Zip PF02535.22 ETO21483.1 - 0.22 10.7 12.6 0.36 10.0 12.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO21483.1 - 0.23 10.2 19.8 0.38 9.5 19.8 1.2 1 0 0 1 1 1 0 Presenilin Drc1-Sld2 PF11719.8 ETO21483.1 - 1.2 8.6 36.7 0.051 13.1 30.9 1.6 2 0 0 2 2 2 0 DNA replication and checkpoint protein SAPS PF04499.15 ETO21483.1 - 1.4 7.6 21.9 2.6 6.7 21.9 1.4 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Mem_trans PF03547.18 ETO21483.1 - 2 6.7 3.3 2.5 6.4 3.3 1.2 1 0 0 1 1 1 0 Membrane transport protein BASP1 PF05466.12 ETO21483.1 - 2.8 7.9 36.4 4.9 7.1 36.4 1.3 1 0 0 1 1 1 0 Brain acid soluble protein 1 (BASP1 protein) SID-1_RNA_chan PF13965.6 ETO21483.1 - 3 6.1 6.6 5.3 5.3 6.6 1.5 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hydin_ADK PF17213.3 ETO21483.1 - 8.9 6.5 10.7 21 5.3 10.7 1.6 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Ras PF00071.22 ETO21485.1 - 1.7e-27 96.0 0.2 2e-27 95.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO21485.1 - 7.3e-06 26.2 0.5 1.6e-05 25.1 0.1 1.8 2 1 1 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase DUF3963 PF13124.6 ETO21485.1 - 0.18 11.8 0.3 0.32 11.0 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3963) SMC_N PF02463.19 ETO21486.1 - 1.5e-28 99.8 12.1 1e-20 74.2 0.5 3.4 2 1 1 3 3 3 3 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO21486.1 - 2.1e-08 34.9 20.6 2.8e-07 31.2 20.0 2.1 1 1 0 1 1 1 1 AAA domain AAA_15 PF13175.6 ETO21486.1 - 4.5e-07 29.9 19.8 1.3e-06 28.4 19.8 1.7 1 1 0 1 1 1 1 AAA ATPase domain AAA_21 PF13304.6 ETO21486.1 - 8.6e-07 29.1 0.8 2.3e-06 27.7 0.3 1.7 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETO21486.1 - 4.8e-05 23.0 0.0 0.00012 21.7 0.0 1.7 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO21486.1 - 0.00052 20.6 0.0 0.00052 20.6 0.0 2.2 2 1 0 2 2 2 1 ABC transporter SHE3 PF17078.5 ETO21486.1 - 0.0038 17.0 8.6 0.0073 16.0 8.6 1.4 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 RsgA_GTPase PF03193.16 ETO21486.1 - 0.03 14.2 1.1 0.53 10.2 0.0 2.6 2 1 0 2 2 2 0 RsgA GTPase MscS_porin PF12795.7 ETO21486.1 - 0.031 13.8 6.8 0.047 13.2 6.8 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain Spc7 PF08317.11 ETO21486.1 - 0.68 8.8 14.7 0.53 9.1 12.8 1.7 2 0 0 2 2 2 0 Spc7 kinetochore protein SMC_N PF02463.19 ETO21487.1 - 1.4e-22 80.2 46.9 4.5e-22 78.6 46.9 2.1 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ETO21487.1 - 1.7e-15 57.3 0.6 2.9e-14 53.3 0.0 3.0 2 1 0 2 2 2 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ETO21487.1 - 0.00022 21.2 0.0 0.00022 21.2 0.0 2.8 3 0 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ETO21487.1 - 0.0016 18.7 0.0 0.79 10.0 0.0 3.0 2 0 0 2 2 2 2 Putative exonuclease SbcCD, C subunit TetR_C_24 PF17932.1 ETO21487.1 - 1.3 9.3 4.2 4 7.7 0.1 3.6 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF4225 PF13988.6 ETO21488.1 - 0.11 12.0 1.6 0.21 11.1 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4225) UPF0242 PF06785.11 ETO21488.1 - 0.23 11.5 29.5 0.057 13.5 13.6 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus CspB_prodomain PF18425.1 ETO21488.1 - 2.1 8.4 8.6 0.14 12.1 1.0 2.8 3 0 0 3 3 3 0 Csp protease B prodomain CLTH PF10607.9 ETO21488.1 - 2.4 8.0 15.6 37 4.2 15.6 2.2 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain HN PF00423.19 ETO21489.1 - 0.22 10.3 3.9 0.17 10.7 1.2 1.8 1 1 1 2 2 2 0 Haemagglutinin-neuraminidase DUF3140 PF11338.8 ETO21489.1 - 0.57 10.7 4.8 4.1 7.9 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3140) Phage_int_SAM_2 PF12834.7 ETO21489.1 - 3.7 8.3 7.7 2.8 8.7 1.6 2.9 2 2 1 3 3 3 0 Phage integrase, N-terminal DJ-1_PfpI PF01965.24 ETO21490.1 - 0.00011 22.1 0.0 0.00036 20.4 0.0 1.9 1 1 0 1 1 1 1 DJ-1/PfpI family DED PF01335.21 ETO21493.1 - 0.00064 20.0 1.9 1.4 9.2 0.0 3.8 4 0 0 4 4 4 2 Death effector domain Sas6_CC PF18594.1 ETO21493.1 - 0.039 13.7 0.6 0.11 12.4 0.6 1.8 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain Acetyltransf_19 PF18015.1 ETO21493.1 - 0.068 13.4 0.9 0.17 12.1 0.3 2.0 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Actin PF00022.19 ETO21494.1 - 9.9e-145 482.2 0.0 3.2e-144 480.5 0.0 1.6 1 1 0 1 1 1 1 Actin GerD PF17898.1 ETO21494.1 - 0.077 12.9 0.0 0.19 11.7 0.0 1.6 1 0 0 1 1 1 0 Spore germination GerD central core domain SGS PF05002.15 ETO21494.1 - 0.15 12.2 0.3 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 SGS domain EXS PF03124.14 ETO21495.1 - 8e-07 28.7 0.2 9.9e-07 28.4 0.2 1.1 1 0 0 1 1 1 1 EXS family Archaeal_AmoA PF12942.7 ETO21495.1 - 0.19 11.4 0.0 0.31 10.7 0.0 1.3 1 0 0 1 1 1 0 Archaeal ammonia monooxygenase subunit A (AmoA) EFG_IV PF03764.18 ETO21496.1 - 9.5e-23 80.3 0.0 1.9e-22 79.3 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ETO21496.1 - 3.1e-21 75.2 0.0 5.5e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETO21496.1 - 3.1e-14 53.1 0.1 2.4e-13 50.3 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ETO21496.1 - 5.6e-13 48.8 0.0 1e-12 47.9 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU PF00009.27 ETO21497.1 - 1.8e-62 210.3 0.0 2.1e-62 210.1 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO21497.1 - 0.00053 20.1 0.0 0.0012 18.9 0.0 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO21497.1 - 0.014 15.3 0.0 0.28 11.1 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase Septin PF00735.18 ETO21497.1 - 0.04 13.2 0.1 0.054 12.8 0.1 1.3 1 0 0 1 1 1 0 Septin MMPL PF03176.15 ETO21499.1 - 1.6e-21 76.6 0.3 2.3e-21 76.1 0.3 1.2 1 0 0 1 1 1 1 MMPL family MMPL PF03176.15 ETO21500.1 - 5.4e-10 38.7 0.0 8.2e-10 38.1 0.0 1.2 1 0 0 1 1 1 1 MMPL family Kelch_1 PF01344.25 ETO21501.1 - 2.7e-11 42.9 19.2 4.8e-05 22.9 0.1 7.0 6 2 0 6 6 6 4 Kelch motif Kelch_4 PF13418.6 ETO21501.1 - 4.6e-11 42.5 1.2 8.1e-05 22.6 0.0 5.1 5 0 0 5 5 5 3 Galactose oxidase, central domain zf-RanBP PF00641.18 ETO21501.1 - 0.00011 21.5 2.2 0.00042 19.6 2.2 2.1 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Kelch_6 PF13964.6 ETO21501.1 - 0.016 15.5 4.5 1.3 9.4 0.0 4.5 6 0 0 6 6 6 0 Kelch motif Kelch_3 PF13415.6 ETO21501.1 - 0.047 14.0 3.4 0.17 12.2 0.1 3.5 3 1 1 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO21501.1 - 0.047 13.7 1.2 0.51 10.4 0.0 3.3 4 0 0 4 4 4 0 Kelch motif zinc-ribbon_6 PF10005.9 ETO21501.1 - 0.06 14.0 5.3 0.12 13.1 1.3 2.7 2 0 0 2 2 2 0 zinc-ribbon domain DUSP PF06337.12 ETO21502.1 - 6e-11 42.8 1.7 1.6e-08 35.0 1.7 2.7 1 1 0 1 1 1 1 DUSP domain Arteri_env PF01606.16 ETO21502.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Arterivirus envelope protein EVI2A PF05399.11 ETO21502.1 - 9 5.8 9.7 0.95 9.0 4.8 1.8 2 0 0 2 2 2 0 Ectropic viral integration site 2A protein (EVI2A) DUF1765 PF08578.10 ETO21503.1 - 0.00059 20.3 0.0 0.0008 19.9 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1765) Acetyltransf_1 PF00583.25 ETO21504.1 - 3.6e-09 36.9 0.0 6.8e-09 36.0 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO21504.1 - 0.00011 22.6 0.1 0.00021 21.7 0.1 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO21504.1 - 0.0022 17.9 0.0 0.0048 16.8 0.0 1.5 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_9 PF13527.7 ETO21504.1 - 0.0059 16.7 0.0 0.0098 16.0 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ETO21504.1 - 0.0065 16.0 0.2 0.01 15.3 0.2 1.4 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_10 PF13673.7 ETO21504.1 - 0.0087 16.0 0.0 0.014 15.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain PT-HINT PF07591.11 ETO21506.1 - 5.1e-07 30.0 0.2 2.9e-06 27.6 0.2 1.9 1 1 0 1 1 1 1 Pretoxin HINT domain Intein_splicing PF14890.6 ETO21506.1 - 6.9e-07 29.3 0.1 5.3e-06 26.4 0.1 1.9 1 1 0 1 1 1 1 Intein splicing domain AXH PF08517.12 ETO21506.1 - 4.8e-06 27.1 0.1 8.6e-06 26.3 0.0 1.5 1 1 0 1 1 1 1 Ataxin-1 and HBP1 module (AXH) YajC PF02699.15 ETO21506.1 - 0.012 15.4 0.0 0.017 15.0 0.0 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit TPR_12 PF13424.6 ETO21507.1 - 2e-52 175.4 18.3 3.9e-14 52.7 0.0 4.9 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO21507.1 - 4.3e-25 86.8 4.3 1.8e-07 30.8 0.0 6.7 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO21507.1 - 5.8e-23 79.2 4.1 3.4e-06 26.7 0.0 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO21507.1 - 1.6e-19 68.8 24.1 2.3e-05 24.0 1.1 5.8 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21507.1 - 5.1e-16 57.5 19.7 0.00062 19.8 1.1 5.6 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21507.1 - 1.4e-13 49.8 19.9 0.0017 18.4 0.4 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat MIT PF04212.18 ETO21507.1 - 0.00018 21.5 7.2 9.5 6.4 0.1 5.4 5 0 0 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETO21507.1 - 0.00097 18.6 0.1 1.2 8.4 0.0 2.5 1 1 1 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 ETO21507.1 - 0.0014 19.2 0.1 17 6.5 0.0 4.2 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO21507.1 - 0.011 16.3 2.8 5.3 7.9 0.1 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO21507.1 - 0.014 14.9 0.0 2.1 7.9 0.0 2.7 2 0 0 2 2 2 0 SHNi-TPR Phage_lysozyme PF00959.19 ETO21507.1 - 0.04 14.4 0.9 0.11 13.0 0.3 2.0 2 0 0 2 2 2 0 Phage lysozyme TPR_11 PF13414.6 ETO21507.1 - 0.33 10.7 21.7 4.1 7.2 1.1 6.6 6 2 2 8 8 8 0 TPR repeat Sel1 PF08238.12 ETO21507.1 - 0.79 10.5 2.4 18 6.2 0.1 3.6 3 0 0 3 3 3 0 Sel1 repeat PPR PF01535.20 ETO21507.1 - 0.88 10.0 4.9 28 5.3 0.0 4.0 4 0 0 4 4 3 0 PPR repeat Enkurin PF13864.6 ETO21508.1 - 4.4e-20 72.0 14.0 8.1e-20 71.1 14.0 1.5 1 0 0 1 1 1 1 Calmodulin-binding OSCP PF00213.18 ETO21508.1 - 0.061 13.4 6.3 0.093 12.8 6.3 1.3 1 0 0 1 1 1 0 ATP synthase delta (OSCP) subunit Arylsulfotran_N PF17425.2 ETO21508.1 - 0.067 13.2 0.0 2.1 8.5 0.0 2.5 2 0 0 2 2 2 0 Arylsulfotransferase Ig-like domain Synaptonemal_3 PF15191.6 ETO21508.1 - 0.12 12.1 3.9 0.14 11.9 0.2 2.5 2 1 0 2 2 2 0 Synaptonemal complex central element protein 3 NPV_P10 PF05531.12 ETO21510.1 - 7.4e-05 23.1 2.2 0.00018 21.9 2.0 1.7 1 1 0 1 1 1 1 Nucleopolyhedrovirus P10 protein TMPIT PF07851.13 ETO21510.1 - 0.00029 20.2 1.1 0.00043 19.6 1.1 1.2 1 0 0 1 1 1 1 TMPIT-like protein DUF3450 PF11932.8 ETO21510.1 - 0.00049 19.5 5.7 0.00075 18.9 5.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF812 PF05667.11 ETO21510.1 - 0.00053 19.0 0.3 0.00056 18.9 0.3 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) TMCO5 PF14992.6 ETO21510.1 - 0.00067 19.3 5.8 0.072 12.7 4.1 2.0 2 0 0 2 2 2 1 TMCO5 family HAP1_N PF04849.13 ETO21510.1 - 0.0008 18.7 4.6 0.0013 18.0 4.6 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region Baculo_PEP_C PF04513.12 ETO21510.1 - 0.00087 19.3 1.1 0.0015 18.6 1.1 1.4 1 0 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus FPP PF05911.11 ETO21510.1 - 0.00093 17.5 4.3 0.0012 17.1 4.3 1.2 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil UPF0242 PF06785.11 ETO21510.1 - 0.0011 19.1 0.1 0.0022 18.2 0.1 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus TACC_C PF05010.14 ETO21510.1 - 0.002 18.0 4.3 0.0034 17.2 4.3 1.3 1 0 0 1 1 1 1 Transforming acidic coiled-coil-containing protein (TACC), C-terminal GAS PF13851.6 ETO21510.1 - 0.0037 16.7 2.5 0.0072 15.7 2.5 1.4 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 ETO21510.1 - 0.0038 17.4 4.2 0.0093 16.2 4.2 1.7 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding CENP-F_leu_zip PF10473.9 ETO21510.1 - 0.0051 16.8 9.8 0.013 15.5 9.9 1.6 1 1 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 LPP PF04728.13 ETO21510.1 - 0.0053 17.1 1.9 0.11 13.0 0.9 2.5 1 1 0 2 2 2 1 Lipoprotein leucine-zipper TolA_bind_tri PF16331.5 ETO21510.1 - 0.0073 16.4 4.8 0.013 15.6 2.4 2.3 1 1 1 2 2 2 1 TolA binding protein trimerisation PspA_IM30 PF04012.12 ETO21510.1 - 0.0074 15.9 0.7 0.012 15.2 0.7 1.3 1 0 0 1 1 1 1 PspA/IM30 family ADIP PF11559.8 ETO21510.1 - 0.0082 16.2 4.9 0.014 15.5 4.9 1.3 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding DUF4763 PF15960.5 ETO21510.1 - 0.0084 15.4 6.0 0.014 14.7 6.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4763) Tropomyosin_1 PF12718.7 ETO21510.1 - 0.0088 16.2 4.1 0.015 15.4 4.1 1.4 1 0 0 1 1 1 1 Tropomyosin like Spc7 PF08317.11 ETO21510.1 - 0.01 14.7 3.2 0.016 14.1 3.2 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein BLOC1_2 PF10046.9 ETO21510.1 - 0.011 16.0 4.4 0.011 16.0 4.4 1.7 2 0 0 2 2 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HemX PF04375.14 ETO21510.1 - 0.011 15.0 0.2 0.016 14.5 0.2 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Seryl_tRNA_N PF02403.22 ETO21510.1 - 0.012 15.8 1.1 0.012 15.8 1.1 1.9 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain HAUS-augmin3 PF14932.6 ETO21510.1 - 0.014 15.0 2.3 0.023 14.3 2.3 1.3 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Lipoprotein_7 PF01540.16 ETO21510.1 - 0.016 14.6 0.2 0.016 14.5 0.2 1.1 1 0 0 1 1 1 0 Adhesin lipoprotein ATG16 PF08614.11 ETO21510.1 - 0.018 15.3 5.2 0.018 15.3 5.2 1.6 2 0 0 2 2 1 0 Autophagy protein 16 (ATG16) Fzo_mitofusin PF04799.13 ETO21510.1 - 0.02 14.5 2.6 0.04 13.5 2.6 1.6 1 1 0 1 1 1 0 fzo-like conserved region Claudin_2 PF13903.6 ETO21510.1 - 0.021 14.6 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction LMBR1 PF04791.16 ETO21510.1 - 0.04 12.8 0.1 0.047 12.6 0.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Syntaxin_2 PF14523.6 ETO21510.1 - 0.041 14.2 2.7 0.062 13.7 1.9 1.7 1 1 1 2 2 2 0 Syntaxin-like protein DUF724 PF05266.14 ETO21510.1 - 0.043 13.6 2.7 0.079 12.8 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Snapin_Pallidin PF14712.6 ETO21510.1 - 0.05 14.0 2.9 0.1 13.0 2.9 1.6 1 0 0 1 1 1 0 Snapin/Pallidin DUF4795 PF16043.5 ETO21510.1 - 0.051 13.2 2.6 0.087 12.4 2.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) Med28 PF11594.8 ETO21510.1 - 0.051 13.6 1.1 0.081 13.0 1.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 28 SlyX PF04102.12 ETO21510.1 - 0.054 14.1 2.7 0.17 12.5 2.8 1.8 1 1 0 1 1 1 0 SlyX WXG100 PF06013.12 ETO21510.1 - 0.054 13.7 1.3 1.4 9.2 1.3 2.3 1 1 0 1 1 1 0 Proteins of 100 residues with WXG DUF1664 PF07889.12 ETO21510.1 - 0.059 13.4 5.1 0.19 11.8 2.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 ETO21510.1 - 0.092 13.0 0.6 0.23 11.7 0.6 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Tho2 PF11262.8 ETO21510.1 - 0.092 11.9 1.4 0.16 11.2 1.4 1.3 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 MHC_II_beta PF00969.19 ETO21510.1 - 0.098 12.8 0.4 0.2 11.8 0.2 1.6 1 1 0 1 1 1 0 Class II histocompatibility antigen, beta domain DUF2205 PF10224.9 ETO21510.1 - 0.12 12.4 5.2 2.1 8.4 4.8 2.5 1 1 1 2 2 2 0 Short coiled-coil protein DUF3377 PF11857.8 ETO21510.1 - 0.14 12.1 1.0 0.32 10.9 1.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) SpecificRecomb PF10136.9 ETO21510.1 - 0.19 10.0 0.6 0.26 9.6 0.6 1.1 1 0 0 1 1 1 0 Site-specific recombinase DUF1732 PF08340.11 ETO21510.1 - 0.19 11.7 2.6 0.34 10.9 2.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1732) Syntaxin-6_N PF09177.11 ETO21510.1 - 0.2 12.2 4.9 0.56 10.8 4.9 1.8 1 1 0 1 1 1 0 Syntaxin 6, N-terminal Laminin_II PF06009.12 ETO21510.1 - 0.22 11.5 3.9 0.61 10.1 3.9 1.6 1 1 0 1 1 1 0 Laminin Domain II bZIP_1 PF00170.21 ETO21510.1 - 0.22 11.6 2.8 1.7 8.8 1.0 2.5 2 1 0 2 2 2 0 bZIP transcription factor Spc24 PF08286.11 ETO21510.1 - 0.22 11.8 7.6 2.2 8.6 7.6 2.3 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 FapA PF03961.13 ETO21510.1 - 0.22 10.1 3.1 0.33 9.5 3.1 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DivIC PF04977.15 ETO21510.1 - 0.23 11.2 5.9 16 5.3 4.9 2.9 1 1 1 2 2 2 0 Septum formation initiator DUF4407 PF14362.6 ETO21510.1 - 0.33 10.2 3.0 0.37 10.1 1.4 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Fib_alpha PF08702.10 ETO21510.1 - 0.34 11.1 4.1 0.34 11.1 1.8 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Phage_GP20 PF06810.11 ETO21510.1 - 0.36 10.6 6.4 0.078 12.8 2.9 1.6 2 0 0 2 2 1 0 Phage minor structural protein GP20 FlaC_arch PF05377.11 ETO21510.1 - 0.57 10.6 7.1 2.7 8.5 2.8 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Lectin_N PF03954.14 ETO21510.1 - 0.64 9.8 5.5 0.77 9.5 2.3 2.2 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain PRKG1_interact PF15898.5 ETO21510.1 - 0.75 10.7 8.3 0.12 13.3 4.3 1.6 2 0 0 2 2 1 0 cGMP-dependent protein kinase interacting domain APG6_N PF17675.1 ETO21510.1 - 0.8 10.2 8.5 2.1 8.9 8.5 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF641 PF04859.12 ETO21510.1 - 0.95 9.8 6.0 0.19 12.1 2.4 1.6 2 0 0 2 2 1 0 Plant protein of unknown function (DUF641) BRE1 PF08647.11 ETO21510.1 - 0.96 9.6 10.3 0.19 11.8 6.7 1.7 2 1 0 2 2 1 0 BRE1 E3 ubiquitin ligase Fungal_TACC PF12709.7 ETO21510.1 - 1.1 9.7 7.5 6.9 7.2 1.5 2.5 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins STAT_alpha PF01017.20 ETO21510.1 - 1.1 9.1 8.2 0.17 11.8 4.6 1.4 2 0 0 2 2 1 0 STAT protein, all-alpha domain GIT_CC PF16559.5 ETO21510.1 - 1.3 8.9 9.5 1.9 8.4 7.1 2.4 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor YabA PF06156.13 ETO21510.1 - 1.7 9.3 7.5 3.2 8.5 1.5 2.6 1 1 1 2 2 2 0 Initiation control protein YabA Cep57_CLD_2 PF14197.6 ETO21510.1 - 2.6 8.2 10.8 12 6.1 10.2 2.1 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 BST2 PF16716.5 ETO21510.1 - 3.2 8.4 11.5 0.73 10.5 7.4 2.0 2 1 0 2 2 1 0 Bone marrow stromal antigen 2 ZapB PF06005.12 ETO21510.1 - 9.3 6.8 11.5 3.3e+02 1.8 11.5 2.5 1 1 0 1 1 1 0 Cell division protein ZapB DUF5362 PF17319.2 ETO21512.1 - 0.0083 15.9 3.4 0.013 15.4 3.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5362) DUF533 PF04391.12 ETO21512.1 - 0.047 13.3 2.2 0.07 12.7 2.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF533) MotA_ExbB PF01618.16 ETO21512.1 - 0.052 13.3 5.2 0.035 13.8 2.6 2.0 1 1 1 2 2 2 0 MotA/TolQ/ExbB proton channel family DUF2681 PF10883.8 ETO21512.1 - 0.062 13.7 0.5 0.11 13.0 0.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) DUF2370 PF10176.9 ETO21512.1 - 0.1 12.2 0.1 0.14 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) Peptidase_M48 PF01435.18 ETO21513.1 - 8.2e-05 22.5 1.4 0.00011 22.0 1.4 1.2 1 0 0 1 1 1 1 Peptidase family M48 ASFV_J13L PF05568.11 ETO21513.1 - 0.024 14.4 9.0 0.037 13.8 9.0 1.4 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF5385 PF17359.2 ETO21513.1 - 0.26 10.8 8.7 0.4 10.2 8.7 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Stevor PF17410.2 ETO21513.1 - 7 6.1 7.6 10 5.5 7.6 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF2207 PF09972.9 ETO21513.1 - 9.7 4.8 11.2 13 4.4 11.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) TPR_17 PF13431.6 ETO21515.1 - 0.018 15.4 0.4 0.11 12.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat PipA PF07108.11 ETO21515.1 - 0.019 14.5 0.6 0.032 13.8 0.6 1.3 1 0 0 1 1 1 0 PipA protein Alanine_zipper PF11839.8 ETO21515.1 - 0.64 10.4 15.6 0.16 12.3 5.1 2.5 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein TPR_6 PF13174.6 ETO21515.1 - 0.95 10.2 0.1 0.95 10.2 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat NARP1 PF12569.8 ETO21515.1 - 1.1 8.1 18.3 1.2 8.0 8.7 2.5 2 1 0 2 2 2 0 NMDA receptor-regulated protein 1 Ac110_PIF PF07280.11 ETO21516.1 - 0.46 10.3 5.5 1.3 8.9 5.5 1.8 1 0 0 1 1 1 0 Per os infectivity factor AC110 EF-hand_8 PF13833.6 ETO21517.1 - 7e-09 35.4 0.3 1.6e-08 34.3 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO21517.1 - 1.9e-05 23.9 0.1 0.052 13.1 0.0 3.3 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO21517.1 - 0.00027 20.6 0.1 0.014 15.3 0.0 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ETO21517.1 - 0.0019 18.6 0.9 0.0031 17.9 0.2 1.8 2 1 0 2 2 2 1 EF-hand domain pair SAM_2 PF07647.17 ETO21518.1 - 4.1e-25 87.7 8.2 3.4e-08 33.5 0.1 4.1 3 0 0 3 3 3 3 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO21518.1 - 1e-22 80.3 14.0 1.4e-09 38.3 0.1 3.8 4 0 0 4 4 3 3 SAM domain (Sterile alpha motif) FliJ PF02050.16 ETO21518.1 - 0.0016 18.6 6.7 0.0016 18.6 6.7 5.2 6 0 0 6 6 5 1 Flagellar FliJ protein SAM_PNT PF02198.16 ETO21518.1 - 0.0093 15.9 2.2 2.2 8.3 0.1 3.5 3 0 0 3 3 3 1 Sterile alpha motif (SAM)/Pointed domain Bap31_Bap29_C PF18035.1 ETO21518.1 - 0.02 14.9 0.7 0.02 14.9 0.7 6.3 6 2 1 7 7 6 0 Bap31/Bap29 cytoplasmic coiled-coil domain Phage_lysis PF03245.13 ETO21518.1 - 0.021 14.9 2.0 0.021 14.9 2.0 3.9 3 1 1 4 4 4 0 Bacteriophage Rz lysis protein Filament PF00038.21 ETO21518.1 - 0.79 9.3 35.6 4 6.9 0.5 4.4 3 1 0 3 3 3 0 Intermediate filament protein DUF3800 PF12686.7 ETO21518.1 - 0.8 10.4 4.5 1.5e+02 3.0 4.2 3.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) FlaC_arch PF05377.11 ETO21518.1 - 1.1 9.8 20.2 16 6.0 0.3 5.9 5 1 1 6 6 6 0 Flagella accessory protein C (FlaC) UPF0242 PF06785.11 ETO21518.1 - 1.1 9.4 43.7 0.78 9.8 13.9 4.5 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF5320 PF17253.2 ETO21518.1 - 1.5 9.9 17.8 4.2 8.5 0.1 4.5 4 0 0 4 4 4 0 Family of unknown function (DUF5320) Spc7 PF08317.11 ETO21518.1 - 1.5 7.6 44.5 0.42 9.5 16.5 4.2 3 1 1 4 4 4 0 Spc7 kinetochore protein CENP-C_mid PF15620.6 ETO21518.1 - 1.7 8.6 17.0 3.5 7.5 17.0 1.5 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region Atg14 PF10186.9 ETO21518.1 - 1.7 7.7 35.5 0.0087 15.2 12.1 3.9 3 1 1 4 4 4 0 Vacuolar sorting 38 and autophagy-related subunit 14 Potass_KdpF PF09604.10 ETO21518.1 - 1.7 8.7 5.1 2.6 8.1 5.1 1.3 1 0 0 1 1 1 0 F subunit of K+-transporting ATPase (Potass_KdpF) Seryl_tRNA_N PF02403.22 ETO21518.1 - 1.8 8.8 35.7 0.58 10.4 10.4 4.9 4 0 0 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Fez1 PF06818.15 ETO21518.1 - 1.8 9.0 34.5 3.5 8.0 0.1 3.9 3 1 0 3 3 3 0 Fez1 WXG100 PF06013.12 ETO21518.1 - 2.4 8.5 12.1 0.47 10.7 3.2 3.7 4 0 0 4 4 3 0 Proteins of 100 residues with WXG DUF4140 PF13600.6 ETO21518.1 - 4.9 7.7 32.7 5.3 7.5 1.8 5.7 3 1 2 5 5 5 0 N-terminal domain of unknown function (DUF4140) TPR_MLP1_2 PF07926.12 ETO21518.1 - 5.5 7.1 51.3 0.036 14.1 14.3 5.0 3 1 0 4 4 4 0 TPR/MLP1/MLP2-like protein AKNA PF12443.8 ETO21518.1 - 6.2 7.6 31.5 0.38 11.4 1.3 6.0 4 1 2 6 6 6 0 AT-hook-containing transcription factor DUF724 PF05266.14 ETO21518.1 - 6.4 6.6 28.7 5.2 6.8 8.4 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF724) Rootletin PF15035.6 ETO21518.1 - 7.9 6.5 35.1 0.59 10.1 0.9 4.1 3 1 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion PRKG1_interact PF15898.5 ETO21518.1 - 9.3 7.2 34.8 21 6.1 0.1 5.2 3 1 2 5 5 5 0 cGMP-dependent protein kinase interacting domain PrmA PF06325.13 ETO21519.1 - 6.4e-11 42.2 0.0 9.9e-11 41.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) SH3_2 PF07653.17 ETO21519.1 - 3.7e-09 36.1 0.0 7.4e-09 35.2 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain Methyltransf_25 PF13649.6 ETO21519.1 - 1.1e-08 35.7 0.1 4.1e-08 33.8 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain SH3_9 PF14604.6 ETO21519.1 - 5e-08 32.7 0.3 1e-07 31.7 0.2 1.6 2 0 0 2 2 1 1 Variant SH3 domain Methyltransf_11 PF08241.12 ETO21519.1 - 5.9e-07 30.1 0.0 1.4e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain SH3_1 PF00018.28 ETO21519.1 - 1.8e-06 27.5 0.1 3.4e-06 26.6 0.1 1.5 1 0 0 1 1 1 1 SH3 domain MTS PF05175.14 ETO21519.1 - 2e-06 27.5 0.0 2.6e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_23 PF13489.6 ETO21519.1 - 2.1e-05 24.4 0.0 3e-05 23.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Cons_hypoth95 PF03602.15 ETO21519.1 - 5.1e-05 23.0 0.0 8e-05 22.3 0.0 1.3 1 0 0 1 1 1 1 Conserved hypothetical protein 95 Methyltransf_18 PF12847.7 ETO21519.1 - 8e-05 22.6 0.3 0.0002 21.3 0.2 1.6 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO21519.1 - 0.0001 22.2 0.0 0.00017 21.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ETO21519.1 - 0.0027 17.5 0.1 0.0041 16.9 0.1 1.3 1 0 0 1 1 1 1 Met-10+ like-protein CMAS PF02353.20 ETO21519.1 - 0.01 15.2 0.0 0.013 14.8 0.0 1.2 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Methyltransf_12 PF08242.12 ETO21519.1 - 0.017 15.8 0.0 0.043 14.5 0.0 1.7 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_32 PF13679.6 ETO21519.1 - 0.02 14.9 0.1 0.04 13.9 0.1 1.5 1 1 0 1 1 1 0 Methyltransferase domain Methyltransf_24 PF13578.6 ETO21519.1 - 0.029 15.4 0.0 0.083 13.9 0.0 1.7 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_9 PF08003.11 ETO21519.1 - 0.034 13.1 0.0 0.044 12.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.19 ETO21519.1 - 0.06 13.1 0.1 0.083 12.6 0.1 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FAM219A PF15260.6 ETO21519.1 - 0.074 13.4 0.2 0.12 12.8 0.2 1.2 1 0 0 1 1 1 0 Protein family FAM219A zf-RanBP PF00641.18 ETO21522.1 - 0.00069 18.9 5.7 0.0017 17.6 5.7 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DZR PF12773.7 ETO21522.1 - 0.02 14.9 1.3 0.047 13.7 1.3 1.5 1 0 0 1 1 1 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ETO21522.1 - 5 7.0 6.5 13 5.7 6.5 1.7 1 0 0 1 1 1 0 zinc-ribbon domain LNS2 PF08235.13 ETO21523.1 - 7.2e-63 212.1 0.0 1.5e-62 211.0 0.0 1.5 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 ETO21523.1 - 1.5e-12 47.3 0.0 4.5e-12 45.8 0.0 1.8 1 0 0 1 1 1 1 lipin, N-terminal conserved region RNA_pol_Rpb1_7 PF04990.12 ETO21523.1 - 0.0051 16.8 2.2 0.02 14.9 1.2 2.4 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 7 PNK3P PF08645.11 ETO21523.1 - 0.01 15.5 0.0 0.029 14.0 0.0 1.8 1 0 0 1 1 1 0 Polynucleotide kinase 3 phosphatase PITH PF06201.13 ETO21524.1 - 0.0012 19.1 0.1 0.002 18.3 0.1 1.4 1 0 0 1 1 1 1 PITH domain F-box-like PF12937.7 ETO21525.1 - 1.7e-06 27.8 0.5 8.4e-06 25.6 0.7 2.0 2 0 0 2 2 2 1 F-box-like DHO_dh PF01180.21 ETO21526.1 - 0.098 11.9 2.3 0.12 11.6 2.3 1.2 1 0 0 1 1 1 0 Dihydroorotate dehydrogenase RGS PF00615.19 ETO21527.1 - 0.0024 18.1 1.2 0.0063 16.8 0.0 2.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain CN_hydrolase PF00795.22 ETO21528.1 - 7.5e-28 97.6 0.0 1.2e-27 96.9 0.0 1.3 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Pho88 PF10032.9 ETO21528.1 - 0.084 12.1 1.5 0.15 11.3 1.5 1.3 1 0 0 1 1 1 0 Phosphate transport (Pho88) UCH PF00443.29 ETO21529.1 - 2.2e-07 30.6 1.7 2.2e-07 30.6 1.7 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Bac_small_YrzI PF09501.10 ETO21529.1 - 0.12 12.6 2.6 1.9 8.7 0.0 2.8 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) Ribosomal_S4Pg PF11993.8 ETO21529.1 - 2.3 8.3 10.4 0.48 10.5 1.7 2.1 2 0 0 2 2 2 0 Ribosomal S4P (gammaproteobacterial) Glyco_transf_10 PF00852.19 ETO21530.1 - 2.7e-33 115.2 0.1 5e-33 114.3 0.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 10 (fucosyltransferase) C-term RRM_1 PF00076.22 ETO21532.1 - 5e-06 26.2 0.0 1.2e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_Ag35 PF03286.14 ETO21532.1 - 0.074 12.8 22.0 0.82 9.4 4.4 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CNDH2_C PF16858.5 ETO21532.1 - 0.13 12.1 13.8 0.6 9.9 1.8 2.1 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 ETO21532.1 - 0.26 9.6 12.0 0.48 8.7 5.0 2.1 2 0 0 2 2 2 0 CDC45-like protein DUF4228 PF14009.6 ETO21532.1 - 1.1 9.6 6.4 14 6.0 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) FAM60A PF15396.6 ETO21532.1 - 1.5 8.8 16.6 3.3 7.7 4.2 2.3 2 0 0 2 2 2 0 Protein Family FAM60A RMI1_N PF08585.12 ETO21532.1 - 2.2 8.0 12.8 1.1 9.0 1.6 2.3 2 0 0 2 2 2 0 RecQ mediated genome instability protein Neur_chan_memb PF02932.16 ETO21532.1 - 3.4 7.7 10.0 7.8 6.5 1.0 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Apis_Csd PF11671.8 ETO21532.1 - 4.7 7.2 34.0 7.4 6.6 15.9 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein Lant_dehydr_N PF04738.13 ETO21533.1 - 0.054 11.6 0.3 0.069 11.2 0.3 1.0 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus MIF PF01187.18 ETO21533.1 - 0.1 12.9 0.1 0.28 11.5 0.0 1.7 2 0 0 2 2 2 0 Macrophage migration inhibitory factor (MIF) DUF2278 PF10042.9 ETO21534.1 - 0.031 14.3 0.4 0.061 13.3 0.4 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2278) 2OG-FeII_Oxy PF03171.20 ETO21536.1 - 0.0012 19.3 0.4 0.0075 16.7 0.4 2.1 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Glyco_transf_4 PF13439.6 ETO21537.1 - 3.4e-07 30.4 0.0 6.3e-07 29.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase Family 4 Glyco_trans_4_4 PF13579.6 ETO21537.1 - 0.0044 17.5 0.0 0.0079 16.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferase 4-like domain Sterile PF03015.19 ETO21537.1 - 0.02 15.1 0.9 0.27 11.5 0.1 3.1 3 1 0 3 3 3 0 Male sterility protein Glyco_trans_1_4 PF13692.6 ETO21537.1 - 0.021 15.2 0.0 0.39 11.2 0.0 2.7 2 1 0 2 2 2 0 Glycosyl transferases group 1 BLACT_WH PF17778.1 ETO21538.1 - 0.073 13.1 0.2 0.14 12.1 0.2 1.4 1 0 0 1 1 1 0 Beta-lactamase associated winged helix domain BRE PF06113.12 ETO21538.1 - 0.49 9.2 2.4 11 4.7 0.2 2.1 2 0 0 2 2 2 0 Brain and reproductive organ-expressed protein (BRE) Pet20 PF08692.10 ETO21538.1 - 7.6 7.3 6.9 1e+02 3.6 6.9 2.5 1 1 0 1 1 1 0 Mitochondrial protein Pet20 Orf78 PF06024.12 ETO21539.1 - 0.0062 16.8 11.1 0.91 9.9 0.0 2.9 3 0 0 3 3 3 2 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO21539.1 - 0.64 10.6 18.5 0.096 13.2 13.8 1.9 2 0 0 2 2 2 0 Secretin N-terminal domain O-antigen_lig PF13425.6 ETO21539.1 - 5.3 5.7 5.1 35 3.0 6.6 1.6 2 0 0 2 2 2 0 O-antigen ligase like membrane protein SDA1 PF05285.12 ETO21539.1 - 5.9 6.2 21.9 9.9 5.5 21.9 1.3 1 1 0 1 1 1 0 SDA1 TetR_C_12 PF16914.5 ETO21540.1 - 0.036 14.2 0.0 0.056 13.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial transcriptional repressor C-terminal NFRKB_winged PF14465.6 ETO21540.1 - 0.093 12.9 0.0 0.13 12.4 0.0 1.3 1 0 0 1 1 1 0 NFRKB Winged Helix-like WWE PF02825.20 ETO21540.1 - 0.14 12.7 0.1 0.25 12.0 0.1 1.4 1 0 0 1 1 1 0 WWE domain Pes-10 PF07149.11 ETO21541.1 - 0.0081 15.3 5.3 0.01 14.9 5.3 1.1 1 0 0 1 1 1 1 Pes-10 CDC45 PF02724.14 ETO21541.1 - 0.02 13.2 15.2 0.026 12.8 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO21541.1 - 0.044 12.3 13.3 0.059 11.9 13.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CNDH2_C PF16858.5 ETO21541.1 - 0.085 12.7 4.4 0.1 12.5 4.4 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term SDA1 PF05285.12 ETO21541.1 - 0.2 11.0 10.7 0.25 10.8 10.7 1.1 1 0 0 1 1 1 0 SDA1 DUF5102 PF17104.5 ETO21541.1 - 0.29 11.1 8.7 0.4 10.7 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) Sigma70_ner PF04546.13 ETO21541.1 - 0.34 10.8 8.1 0.48 10.3 8.1 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2457 PF10446.9 ETO21541.1 - 0.56 9.3 25.9 0.71 8.9 25.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Vfa1 PF08432.10 ETO21541.1 - 0.67 10.3 6.0 0.95 9.8 6.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FAM176 PF14851.6 ETO21541.1 - 0.87 9.2 8.9 1.4 8.5 8.9 1.3 1 0 0 1 1 1 0 FAM176 family Nop14 PF04147.12 ETO21541.1 - 0.93 7.6 15.9 1.1 7.3 15.9 1.0 1 0 0 1 1 1 0 Nop14-like family GCIP PF13324.6 ETO21541.1 - 1 8.9 9.0 1.5 8.3 9.0 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DNA_pol_phi PF04931.13 ETO21541.1 - 1.6 6.7 22.5 2.2 6.3 22.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO21541.1 - 1.7 7.9 26.6 2.4 7.4 26.6 1.1 1 0 0 1 1 1 0 NOA36 protein BUD22 PF09073.10 ETO21541.1 - 2.7 7.2 11.3 3 7.1 11.3 1.1 1 0 0 1 1 1 0 BUD22 DUF2076 PF09849.9 ETO21541.1 - 3.1 7.8 16.5 4.1 7.4 16.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) SGT1 PF07093.11 ETO21541.1 - 3.2 6.1 11.0 4.1 5.7 11.0 1.1 1 0 0 1 1 1 0 SGT1 protein TPR_12 PF13424.6 ETO21542.1 - 5.9e-109 356.5 11.5 3.1e-22 78.6 0.1 5.9 1 1 6 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO21542.1 - 2.5e-68 224.3 0.1 6.9e-12 44.8 0.0 7.8 7 1 1 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO21542.1 - 4.6e-57 186.0 6.7 4.1e-09 35.8 0.0 7.2 7 1 1 8 8 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO21542.1 - 7.1e-51 168.1 33.7 9.1e-11 41.1 1.1 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21542.1 - 5.2e-39 129.2 36.7 2.7e-09 36.5 0.9 7.2 7 1 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21542.1 - 1.9e-38 127.5 20.1 4.5e-08 32.6 0.3 6.6 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO21542.1 - 1.7e-27 93.8 10.6 0.00021 21.4 0.0 6.8 6 2 0 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO21542.1 - 2.5e-25 88.8 0.0 0.00014 22.5 0.0 5.8 4 2 1 5 5 5 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO21542.1 - 1.7e-15 56.4 0.0 0.079 13.8 0.0 6.4 4 2 3 7 7 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO21542.1 - 1.2e-14 53.7 46.0 0.0038 16.9 1.3 10.4 6 4 5 11 11 11 9 TPR repeat TPR_6 PF13174.6 ETO21542.1 - 7.1e-13 48.3 0.4 0.34 11.6 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat PPR PF01535.20 ETO21542.1 - 3e-12 45.9 12.4 0.061 13.6 0.1 6.1 6 0 0 6 6 6 4 PPR repeat TPR_19 PF14559.6 ETO21542.1 - 8.9e-12 45.4 0.6 0.023 15.2 0.0 4.3 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO21542.1 - 9.4e-12 44.9 0.0 1.8e-05 24.3 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region DUF5113 PF17140.4 ETO21542.1 - 4.5e-11 42.8 9.6 0.11 12.3 0.2 5.4 6 0 0 6 6 5 3 Domain of unknown function (DUF5113) SNAP PF14938.6 ETO21542.1 - 4.6e-11 42.7 5.3 1.7e-05 24.4 1.8 3.5 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_3 PF07720.12 ETO21542.1 - 1.5e-08 34.5 24.0 0.079 13.0 0.6 7.1 7 0 0 7 7 7 2 Tetratricopeptide repeat MIT PF04212.18 ETO21542.1 - 2.2e-08 34.1 28.5 0.016 15.2 0.3 6.6 6 1 1 7 7 6 4 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO21542.1 - 2.9e-07 30.4 7.5 0.066 12.9 0.1 4.5 1 1 2 4 4 4 2 26S proteasome subunit RPN7 OrfA PF17495.2 ETO21542.1 - 4.2e-06 26.9 0.0 24 5.2 0.0 5.3 1 1 5 6 6 6 0 Vpr-like OrfA DUF627 PF04781.12 ETO21542.1 - 5.9e-06 26.3 4.6 1 9.4 0.1 4.8 4 2 2 6 6 6 1 Protein of unknown function (DUF627) DUF4810 PF16068.5 ETO21542.1 - 1.6e-05 25.4 5.3 12 6.6 0.0 5.1 4 1 2 6 6 6 0 Domain of unknown function (DUF4810) UBA_6 PF18039.1 ETO21542.1 - 2e-05 24.4 0.0 16 5.5 0.0 5.5 5 1 1 6 6 6 0 UBA-like domain Mad3_BUB1_I PF08311.12 ETO21542.1 - 4.2e-05 23.5 3.3 1.4 8.9 0.0 4.4 5 0 0 5 5 4 1 Mad3/BUB1 homology region 1 HTH_Bact PF18768.1 ETO21542.1 - 0.00014 21.4 8.8 17 5.1 0.1 6.9 6 2 2 8 8 7 0 Helix-turn-helix bacterial domain ANAPC3 PF12895.7 ETO21542.1 - 0.00017 21.8 8.2 2.6 8.3 0.7 4.4 1 1 4 5 5 5 1 Anaphase-promoting complex, cyclosome, subunit 3 SERTA PF06031.13 ETO21542.1 - 0.0029 17.2 0.0 25 4.6 0.0 4.1 4 0 0 4 4 4 0 SERTA motif TPR_9 PF13371.6 ETO21542.1 - 0.0066 16.6 0.0 5.4 7.2 0.0 2.7 1 1 1 3 3 3 0 Tetratricopeptide repeat DUF2262 PF10020.9 ETO21542.1 - 0.01 16.2 0.9 9.6 6.6 0.1 3.3 1 1 3 5 5 5 0 Uncharacterized protein conserved in bacteria (DUF2262) ChuX_HutX PF06228.13 ETO21542.1 - 0.012 15.4 0.0 2.3 8.0 0.0 3.4 2 2 1 3 3 3 0 Haem utilisation ChuX/HutX SHNi-TPR PF10516.9 ETO21542.1 - 0.036 13.5 0.0 35 4.0 0.0 4.4 5 0 0 5 5 4 0 SHNi-TPR Clathrin PF00637.20 ETO21542.1 - 0.038 13.9 5.4 2.2 8.1 0.3 4.1 2 2 1 3 3 3 0 Region in Clathrin and VPS DUF2802 PF10975.8 ETO21542.1 - 0.051 13.7 0.2 26 5.0 0.0 4.0 5 0 0 5 5 4 0 Protein of unknown function (DUF2802) PPR_2 PF13041.6 ETO21542.1 - 0.12 12.6 6.9 14 5.9 0.1 4.4 4 0 0 4 4 4 0 PPR repeat family FATC PF02260.20 ETO21542.1 - 0.18 11.6 1.4 77 3.2 0.0 3.6 4 0 0 4 4 3 0 FATC domain 4HB_MCP_1 PF12729.7 ETO21542.1 - 0.33 10.5 2.8 52 3.3 0.0 4.0 4 1 0 5 5 4 0 Four helix bundle sensory module for signal transduction NRBF2_MIT PF17169.4 ETO21542.1 - 0.4 10.9 6.1 21 5.5 0.0 4.4 5 1 1 6 6 4 0 MIT domain of nuclear receptor-binding factor 2 SPAN-X PF07458.12 ETO21542.1 - 0.44 11.0 6.6 25 5.4 0.0 5.1 6 1 1 7 7 5 0 Sperm protein associated with nucleus, mapped to X chromosome WSS_VP PF12175.8 ETO21542.1 - 0.56 9.7 2.7 6.5 6.2 0.4 3.1 1 1 3 4 4 4 0 White spot syndrome virus structural envelope protein VP KapB PF08810.10 ETO21542.1 - 0.63 10.2 6.0 14 5.9 0.1 4.2 3 2 2 5 5 4 0 Kinase associated protein B TPR_21 PF09976.9 ETO21542.1 - 0.68 9.6 5.5 20 4.8 1.1 3.7 2 2 2 4 4 4 0 Tetratricopeptide repeat-like domain CagS PF16707.5 ETO21542.1 - 0.98 9.4 7.7 11 6.0 0.1 3.5 1 1 3 4 4 4 0 Cag pathogenicity island protein S of Helicobacter pylori SPO22 PF08631.10 ETO21542.1 - 1.2 8.5 2.8 64 2.9 0.1 3.3 3 1 1 4 4 3 0 Meiosis protein SPO22/ZIP4 like HALZ PF02183.18 ETO21542.1 - 2 8.7 5.9 1.1 9.5 0.2 3.7 3 0 0 3 3 2 0 Homeobox associated leucine zipper Sel1 PF08238.12 ETO21542.1 - 2.4 9.0 17.8 20 6.0 0.3 7.1 7 3 0 7 7 6 0 Sel1 repeat DUF3450 PF11932.8 ETO21542.1 - 3.4 6.9 4.7 51 3.1 0.0 3.9 1 1 4 5 5 5 0 Protein of unknown function (DUF3450) PG_binding_2 PF08823.11 ETO21542.1 - 6.4 7.2 7.3 89 3.5 0.0 4.6 3 2 3 6 6 6 0 Putative peptidoglycan binding domain BAR_3 PF16746.5 ETO21542.1 - 8 6.1 10.1 54 3.4 0.1 4.6 6 0 0 6 6 5 0 BAR domain of APPL family CHAT PF12770.7 ETO21543.1 - 3.4e-13 49.6 0.9 5.8e-13 48.9 0.4 1.6 2 0 0 2 2 2 1 CHAT domain Secretin_N_2 PF07655.13 ETO21543.1 - 0.011 16.2 12.8 0.014 15.9 9.7 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Tim54 PF11711.8 ETO21543.1 - 0.098 11.4 0.1 0.098 11.4 0.1 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 NST1 PF13945.6 ETO21543.1 - 0.23 11.5 19.9 1.9 8.5 9.8 2.5 2 0 0 2 2 2 0 Salt tolerance down-regulator Neur_chan_memb PF02932.16 ETO21543.1 - 0.24 11.4 4.1 0.6 10.1 0.3 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Apc15p PF05841.11 ETO21543.1 - 6.7 7.5 15.2 0.95 10.3 7.2 2.8 2 1 0 2 2 2 0 Apc15p protein Rxt3 PF08642.10 ETO21543.1 - 8.4 7.2 11.8 7.1 7.4 0.7 3.1 2 1 0 2 2 2 0 Histone deacetylation protein Rxt3 MAGE PF01454.19 ETO21544.1 - 0.037 13.7 2.1 0.043 13.5 2.1 1.1 1 0 0 1 1 1 0 MAGE family TPR_19 PF14559.6 ETO21545.1 - 0.095 13.2 5.9 1.3 9.6 0.3 4.0 3 1 2 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO21545.1 - 0.23 11.7 5.6 0.33 11.2 0.4 3.5 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DAO PF01266.24 ETO21546.1 - 1.8e-22 80.4 0.0 2.8e-20 73.2 0.0 1.9 2 0 0 2 2 2 2 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETO21546.1 - 0.00051 19.2 0.0 0.00077 18.6 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain FAD_oxidored PF12831.7 ETO21546.1 - 0.013 14.9 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase FAD_binding_3 PF01494.19 ETO21546.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 FAD binding domain DUF3592 PF12158.8 ETO21547.1 - 0.67 10.0 0.0 0.67 10.0 0.0 2.4 4 0 0 4 4 4 0 Protein of unknown function (DUF3592) Thioredoxin PF00085.20 ETO21548.1 - 1.5e-20 73.1 0.1 3.6e-20 71.9 0.1 1.7 1 0 0 1 1 1 1 Thioredoxin Globin PF00042.22 ETO21548.1 - 3.3e-12 46.9 2.3 2.2e-08 34.6 0.3 2.9 2 0 0 2 2 2 2 Globin COPIIcoated_ERV PF07970.12 ETO21548.1 - 5.6e-09 36.2 0.2 1e-05 25.5 0.0 2.6 1 1 1 2 2 2 2 Endoplasmic reticulum vesicle transporter Thioredoxin_8 PF13905.6 ETO21548.1 - 0.0025 18.1 0.3 0.016 15.5 0.1 2.6 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_2 PF13098.6 ETO21548.1 - 0.066 13.7 0.9 0.2 12.1 0.1 2.3 2 0 0 2 2 2 0 Thioredoxin-like domain zf-ANAPC11 PF12861.7 ETO21549.1 - 0.038 14.0 0.8 0.038 14.0 0.8 1.7 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-4CXXC_R1 PF10497.9 ETO21549.1 - 0.1 12.8 7.9 0.2 11.9 7.9 1.4 1 1 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 zf-rbx1 PF12678.7 ETO21549.1 - 0.48 10.8 7.4 1.5 9.1 7.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain IBR PF01485.21 ETO21549.1 - 1.5 9.1 11.3 11 6.4 11.9 2.0 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain Methyltransf_16 PF10294.9 ETO21550.1 - 1e-15 57.9 2.7 6.1e-11 42.4 0.5 2.4 1 1 1 2 2 2 2 Lysine methyltransferase MTS PF05175.14 ETO21550.1 - 2.4e-05 23.9 0.0 5.3e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_25 PF13649.6 ETO21550.1 - 2.9e-05 24.7 0.3 0.00088 19.9 0.0 3.1 3 1 1 4 4 4 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO21550.1 - 0.00027 20.7 3.9 0.021 14.6 3.9 2.5 1 1 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ETO21550.1 - 0.00093 18.7 0.2 0.002 17.5 0.0 1.6 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 ETO21550.1 - 0.0023 17.9 0.3 0.0063 16.5 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO21550.1 - 0.0035 17.9 0.1 0.044 14.4 0.1 2.6 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO21550.1 - 0.0041 17.8 3.6 0.0075 17.0 0.5 2.8 3 1 0 3 3 2 1 Methyltransferase domain PCMT PF01135.19 ETO21550.1 - 0.0042 16.9 0.0 0.0064 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Methyltransf_23 PF13489.6 ETO21550.1 - 0.0091 15.8 0.0 0.021 14.6 0.0 1.6 1 1 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ETO21550.1 - 0.036 13.8 0.1 0.099 12.4 0.1 1.7 1 0 0 1 1 1 0 Met-10+ like-protein DUF4464 PF14713.6 ETO21551.1 - 2.3e-80 269.4 9.2 2e-62 210.7 3.3 2.0 2 0 0 2 2 2 2 Domain of unknown function (DUF4464) DUF5001 PF16392.5 ETO21551.1 - 0.025 14.5 0.1 0.062 13.2 0.1 1.6 1 0 0 1 1 1 0 Ig-like domain Hydrolase_6 PF13344.6 ETO21553.1 - 1.3e-13 50.9 0.0 3.6e-13 49.5 0.0 1.6 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase OCIA PF07051.11 ETO21553.1 - 0.0016 18.4 0.4 0.006 16.6 0.4 1.9 1 0 0 1 1 1 1 Ovarian carcinoma immunoreactive antigen (OCIA) DUF2457 PF10446.9 ETO21555.1 - 0.0041 16.3 37.8 0.0041 16.3 37.8 5.0 2 1 3 5 5 5 1 Protein of unknown function (DUF2457) Endostatin PF06482.11 ETO21557.1 - 0.044 13.3 1.4 0.05 13.1 0.6 1.4 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin CBFD_NFYB_HMF PF00808.23 ETO21559.1 - 0.13 12.6 0.8 0.33 11.3 0.1 2.0 3 0 0 3 3 3 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TRM13 PF05206.14 ETO21560.1 - 0.039 13.5 0.1 0.091 12.3 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase TRM13 DUF755 PF05501.11 ETO21560.1 - 2.8 8.2 6.0 3.5 7.9 0.0 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF755) DUF3450 PF11932.8 ETO21562.1 - 9.9e-05 21.8 0.1 0.00011 21.6 0.1 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Spc7 PF08317.11 ETO21562.1 - 0.0015 17.5 0.2 0.0017 17.3 0.2 1.0 1 0 0 1 1 1 1 Spc7 kinetochore protein bZIP_1 PF00170.21 ETO21562.1 - 0.0022 18.0 1.9 0.003 17.6 0.6 1.8 1 1 1 2 2 2 1 bZIP transcription factor DUF5427 PF10310.9 ETO21562.1 - 0.0051 15.8 0.1 0.0059 15.6 0.1 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5427) CENP-F_leu_zip PF10473.9 ETO21562.1 - 0.0077 16.3 1.1 0.01 15.9 1.1 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HMMR_C PF15908.5 ETO21562.1 - 0.011 16.0 0.9 0.013 15.8 0.9 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal TolA_bind_tri PF16331.5 ETO21562.1 - 0.012 15.7 1.2 0.19 11.8 0.1 2.1 1 1 1 2 2 2 0 TolA binding protein trimerisation Prefoldin_2 PF01920.20 ETO21562.1 - 0.013 15.4 3.1 0.024 14.6 0.9 1.9 1 1 1 2 2 2 0 Prefoldin subunit HAP1_N PF04849.13 ETO21562.1 - 0.017 14.3 1.0 0.021 14.1 1.0 1.0 1 0 0 1 1 1 0 HAP1 N-terminal conserved region DUF5082 PF16888.5 ETO21562.1 - 0.017 15.4 0.2 0.02 15.2 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5082) KASH_CCD PF14662.6 ETO21562.1 - 0.018 14.8 1.2 0.022 14.6 1.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Tektin PF03148.14 ETO21562.1 - 0.022 13.5 0.6 0.024 13.4 0.6 1.1 1 0 0 1 1 1 0 Tektin family GIT_CC PF16559.5 ETO21562.1 - 0.023 14.6 0.1 0.041 13.8 0.1 1.4 1 1 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor TMF_TATA_bd PF12325.8 ETO21562.1 - 0.027 14.7 0.9 0.035 14.3 0.9 1.1 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding CEP209_CC5 PF16574.5 ETO21562.1 - 0.039 14.1 0.2 0.049 13.8 0.2 1.1 1 0 0 1 1 1 0 Coiled-coil region of centrosome protein CE290 Seryl_tRNA_N PF02403.22 ETO21562.1 - 0.04 14.1 0.3 0.055 13.7 0.3 1.3 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4795 PF16043.5 ETO21562.1 - 0.044 13.4 1.7 0.059 13.0 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) HIP1_clath_bdg PF16515.5 ETO21562.1 - 0.052 14.2 1.0 0.079 13.6 1.0 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RPA_interact_M PF14767.6 ETO21562.1 - 0.073 13.7 0.4 0.095 13.3 0.4 1.2 1 0 0 1 1 1 0 Replication protein A interacting middle NPV_P10 PF05531.12 ETO21562.1 - 0.081 13.4 0.3 0.11 13.0 0.3 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein BLOC1_2 PF10046.9 ETO21562.1 - 0.092 13.1 1.1 0.15 12.4 1.1 1.4 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF1664 PF07889.12 ETO21562.1 - 0.093 12.8 0.4 0.23 11.5 0.2 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DivIC PF04977.15 ETO21562.1 - 0.17 11.6 2.0 0.99 9.2 0.7 2.0 1 1 1 2 2 2 0 Septum formation initiator PHM7_cyt PF14703.6 ETO21562.1 - 0.17 12.1 1.1 0.38 11.0 0.2 1.7 1 1 1 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter FA_hydroxylase PF04116.13 ETO21563.1 - 2.5e-18 66.7 4.5 2.5e-18 66.7 4.5 2.8 2 2 1 3 3 3 1 Fatty acid hydroxylase superfamily GREB1 PF15782.5 ETO21565.1 - 7.4 3.5 7.6 8.3 3.4 7.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer NIF PF03031.18 ETO21566.1 - 5.4e-10 39.3 0.1 1.4e-09 37.9 0.0 1.8 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase Cwf_Cwc_15 PF04889.12 ETO21566.1 - 6e-05 22.9 21.3 8.3e-05 22.4 21.3 1.2 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Drc1-Sld2 PF11719.8 ETO21566.1 - 0.0028 17.3 9.1 0.003 17.2 9.1 1.1 1 0 0 1 1 1 1 DNA replication and checkpoint protein DUF2457 PF10446.9 ETO21566.1 - 0.0042 16.3 23.3 0.006 15.8 23.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Spc7_N PF15402.6 ETO21566.1 - 0.039 12.2 7.9 0.055 11.7 7.9 1.3 1 0 0 1 1 1 0 N-terminus of kinetochore NMS complex subunit Spc7 RNA_pol_3_Rpc31 PF11705.8 ETO21566.1 - 0.07 13.4 21.8 0.1 12.8 21.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Nop25 PF09805.9 ETO21566.1 - 0.081 13.4 13.5 0.12 12.8 13.5 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) CNDH2_C PF16858.5 ETO21566.1 - 0.11 12.3 12.2 0.15 11.9 12.2 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Presenilin PF01080.17 ETO21566.1 - 0.13 11.0 3.0 0.16 10.7 3.0 1.1 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO21566.1 - 0.26 10.6 23.1 0.43 9.8 23.1 1.3 1 0 0 1 1 1 0 NOA36 protein DUF1682 PF07946.14 ETO21566.1 - 0.29 10.3 7.2 0.34 10.1 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) BUD22 PF09073.10 ETO21566.1 - 0.48 9.7 14.9 0.71 9.1 14.9 1.3 1 0 0 1 1 1 0 BUD22 DUF1676 PF07898.13 ETO21566.1 - 0.5 10.4 3.7 3.2 7.8 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) FAM60A PF15396.6 ETO21566.1 - 0.95 9.4 6.0 1.3 9.0 6.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A PPP4R2 PF09184.11 ETO21566.1 - 3.5 7.1 21.8 5 6.6 21.8 1.1 1 0 0 1 1 1 0 PPP4R2 CENP-B_dimeris PF09026.10 ETO21566.1 - 6.5 7.2 27.2 0.37 11.2 21.1 2.1 2 0 0 2 2 1 0 Centromere protein B dimerisation domain TFIIA PF03153.13 ETO21566.1 - 7.7 6.4 19.8 10 6.0 19.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Kinesin PF00225.23 ETO21569.1 - 9.8e-67 225.2 4.2 3e-41 141.4 0.1 3.2 2 1 1 3 3 3 3 Kinesin motor domain Microtub_bd PF16796.5 ETO21569.1 - 3.4e-22 79.0 0.9 2.9e-21 76.0 0.1 2.7 2 1 0 2 2 2 1 Microtubule binding Med9 PF07544.13 ETO21569.1 - 0.013 15.6 1.6 0.04 14.0 1.6 1.9 1 0 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.12 ETO21569.1 - 0.14 12.8 8.7 1.6 9.4 3.8 2.8 2 0 0 2 2 2 0 SlyX P4Ha_N PF08336.11 ETO21569.1 - 0.46 10.5 4.9 8 6.5 4.9 2.3 1 1 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region TMF_DNA_bd PF12329.8 ETO21569.1 - 2 8.5 8.6 1.8 8.6 2.6 3.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Pkinase PF00069.25 ETO21570.1 - 1.6e-66 224.4 0.1 5.2e-66 222.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21570.1 - 2.3e-28 99.2 0.0 5.4e-28 98.0 0.0 1.6 1 0 0 1 1 1 1 Protein tyrosine kinase cNMP_binding PF00027.29 ETO21570.1 - 1.4e-12 47.5 0.1 5.7e-05 23.1 0.0 2.7 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain Kinase-like PF14531.6 ETO21570.1 - 0.0063 15.9 0.0 0.02 14.2 0.0 2.0 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO21570.1 - 0.11 12.4 0.0 0.7 9.8 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Baculo_11_kDa PF06143.11 ETO21571.1 - 0.0033 17.0 0.6 0.0068 16.0 0.6 1.5 1 0 0 1 1 1 1 Baculovirus 11 kDa family Vma12 PF11712.8 ETO21571.1 - 0.15 12.1 2.0 0.16 12.0 0.9 1.6 1 1 1 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4446 PF14584.6 ETO21571.1 - 1.1 9.2 8.3 0.17 11.8 1.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) Ly49 PF08391.10 ETO21571.1 - 5.2 7.5 10.4 1 9.8 2.7 2.1 1 1 0 2 2 2 0 Ly49-like protein, N-terminal region ANAPC_CDC26 PF10471.9 ETO21571.1 - 5.3 7.9 9.4 16 6.4 0.4 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 SprA-related PF12118.8 ETO21572.1 - 0.029 13.5 22.3 0.041 13.0 22.3 1.2 1 0 0 1 1 1 0 SprA-related family UPF0560 PF10577.9 ETO21572.1 - 0.24 9.8 19.1 0.2 10.1 18.2 1.3 1 1 0 1 1 1 0 Uncharacterised protein family UPF0560 DivIC PF04977.15 ETO21572.1 - 0.4 10.5 10.0 0.71 9.7 10.0 1.4 1 0 0 1 1 1 0 Septum formation initiator TFIIA PF03153.13 ETO21572.1 - 1.1 9.1 31.1 1.5 8.7 31.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4554 PF15091.6 ETO21572.1 - 2.1 7.2 14.7 2.6 6.8 14.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Membralin PF09746.9 ETO21572.1 - 2.6 7.0 11.3 2.8 6.9 11.3 1.2 1 0 0 1 1 1 0 Tumour-associated protein Rsm1 PF08600.10 ETO21572.1 - 6.4 7.0 8.0 14 5.9 8.0 1.7 1 0 0 1 1 1 0 Rsm1-like DUF4407 PF14362.6 ETO21572.1 - 7.5 5.8 9.7 9.1 5.5 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sld3_N PF18523.1 ETO21572.1 - 9 6.5 12.5 14 5.8 12.4 1.4 1 1 0 1 1 1 0 Sld3 N-terminal domain NUT PF12881.7 ETO21574.1 - 0.00021 19.9 1.6 0.063 11.7 0.2 2.1 1 1 1 2 2 2 2 NUT protein Pkinase PF00069.25 ETO21575.1 - 1.6e-16 60.5 0.0 3.1e-16 59.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21575.1 - 5e-09 35.8 0.0 7.6e-09 35.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase CobT PF06213.12 ETO21575.1 - 0.00089 18.7 3.4 0.0016 17.9 3.4 1.3 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT Cnd2 PF05786.14 ETO21575.1 - 0.0016 17.2 4.9 0.0022 16.8 4.9 1.1 1 0 0 1 1 1 1 Condensin complex subunit 2 DUF2052 PF09747.9 ETO21575.1 - 0.0024 18.0 7.2 0.0038 17.4 7.2 1.4 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) RNA_polI_A34 PF08208.11 ETO21575.1 - 0.0041 17.2 4.5 0.006 16.7 4.5 1.2 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 TFIIF_alpha PF05793.12 ETO21575.1 - 0.015 13.9 9.8 0.022 13.4 9.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CPSF100_C PF13299.6 ETO21575.1 - 0.022 15.0 1.5 0.035 14.3 1.5 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal FAM176 PF14851.6 ETO21575.1 - 0.069 12.8 6.1 0.12 12.0 6.1 1.4 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 ETO21575.1 - 0.19 11.4 0.6 0.3 10.8 0.6 1.3 1 0 0 1 1 1 0 Connexin E7 PF00527.18 ETO21575.1 - 0.37 11.0 5.8 0.9 9.8 5.8 1.7 1 0 0 1 1 1 0 E7 protein, Early protein CDC45 PF02724.14 ETO21575.1 - 0.61 8.3 7.6 0.049 11.9 3.3 1.5 2 0 0 2 2 2 0 CDC45-like protein DAP PF15228.6 ETO21575.1 - 0.83 10.9 6.1 1.7 9.9 2.2 2.5 2 0 0 2 2 2 0 Death-associated protein Ferlin_C PF16165.5 ETO21575.1 - 4.7 7.1 6.9 8.5 6.3 6.9 1.3 1 0 0 1 1 1 0 Ferlin C-terminus GIT_SHD PF08518.11 ETO21577.1 - 1.4 8.6 8.9 3.8 7.2 2.7 2.3 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT PH PF00169.29 ETO21578.1 - 2.3e-09 37.7 2.6 1.9e-08 34.7 0.1 3.3 2 0 0 2 2 2 1 PH domain DUF2362 PF10154.9 ETO21579.1 - 0.007 15.4 3.4 0.0085 15.1 3.4 1.1 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2362) DUF5427 PF10310.9 ETO21580.1 - 0.013 14.5 11.6 0.021 13.8 11.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CDC45 PF02724.14 ETO21580.1 - 0.12 10.6 14.3 0.19 10.0 14.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 ETO21580.1 - 0.14 12.2 3.5 0.24 11.4 3.5 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ndc1_Nup PF09531.10 ETO21580.1 - 0.21 10.2 3.7 0.36 9.5 3.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF908 PF06012.12 ETO21580.1 - 0.22 10.9 2.5 0.31 10.4 2.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Hid1 PF12722.7 ETO21580.1 - 0.25 9.4 7.3 0.32 9.1 7.3 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Raftlin PF15250.6 ETO21580.1 - 0.25 10.1 10.9 0.47 9.1 10.9 1.4 1 0 0 1 1 1 0 Raftlin DUF1158 PF06643.11 ETO21580.1 - 0.4 11.2 2.2 0.72 10.4 2.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1158) Mem_trans PF03547.18 ETO21580.1 - 0.65 8.3 1.9 0.87 7.9 1.9 1.3 1 0 0 1 1 1 0 Membrane transport protein Pes-10 PF07149.11 ETO21580.1 - 3.4 6.6 10.5 5.2 6.0 10.5 1.2 1 0 0 1 1 1 0 Pes-10 Zip PF02535.22 ETO21580.1 - 9.7 5.3 10.1 22 4.1 10.2 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter Mtc PF03820.17 ETO21581.1 - 7.1e-47 160.0 0.2 8e-47 159.8 0.2 1.0 1 0 0 1 1 1 1 Tricarboxylate carrier AA_permease_2 PF13520.6 ETO21582.1 - 2.3 6.9 19.8 0.2 10.4 10.0 2.2 2 0 0 2 2 2 0 Amino acid permease 7tm_3 PF00003.22 ETO21585.1 - 4.5e-09 36.4 13.0 8.3e-09 35.5 13.0 1.4 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Pkinase PF00069.25 ETO21586.1 - 1.8e-13 50.5 0.2 7e-13 48.5 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21586.1 - 1.8e-06 27.4 0.2 0.012 14.9 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO21586.1 - 0.0013 17.6 0.0 0.0017 17.2 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase DUF2645 PF10840.8 ETO21586.1 - 0.045 14.4 1.1 0.08 13.6 1.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2645) ABC1 PF03109.16 ETO21586.1 - 0.15 12.2 0.0 0.35 11.1 0.0 1.5 1 0 0 1 1 1 0 ABC1 family tRNA-synt_2b PF00587.25 ETO21588.1 - 4.9e-21 75.5 0.0 8.7e-21 74.7 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) tRNA_edit PF04073.15 ETO21588.1 - 1.9e-07 31.2 0.0 3.4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain Cellulase PF00150.18 ETO21589.1 - 1e-06 28.4 0.4 1.6e-06 27.7 0.4 1.2 1 0 0 1 1 1 1 Cellulase (glycosyl hydrolase family 5) Glyco_hydro_5_C PF18564.1 ETO21589.1 - 1.5e-06 28.6 1.6 2.2e-06 28.1 0.4 1.9 2 0 0 2 2 2 1 Glycoside hydrolase family 5 C-terminal domain DSPc PF00782.20 ETO21590.1 - 9.5e-14 51.4 0.1 9.5e-14 51.4 0.1 2.8 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain RabGAP-TBC PF00566.18 ETO21591.1 - 1.3e-06 28.2 0.0 2.1e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Rab-GTPase-TBC domain AAA_12 PF13087.6 ETO21592.1 - 3.3e-47 160.7 0.6 1.5e-46 158.6 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_11 PF13086.6 ETO21592.1 - 1.2e-37 130.2 5.1 1.5e-37 129.8 0.0 2.9 4 0 0 4 4 4 1 AAA domain AAA_19 PF13245.6 ETO21592.1 - 6.7e-09 36.2 0.1 4e-08 33.7 0.1 2.3 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ETO21592.1 - 1.5e-07 31.4 0.1 0.0067 16.2 0.0 3.7 4 0 0 4 4 4 2 Viral (Superfamily 1) RNA helicase AAA_30 PF13604.6 ETO21592.1 - 4.3e-07 29.8 0.0 0.05 13.3 0.0 2.9 2 1 1 3 3 3 2 AAA domain DUF2075 PF09848.9 ETO21592.1 - 0.0013 18.0 0.0 0.58 9.3 0.0 3.2 4 0 0 4 4 4 1 Uncharacterized conserved protein (DUF2075) AAA PF00004.29 ETO21592.1 - 0.0066 16.9 0.4 0.066 13.6 0.0 2.8 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETO21592.1 - 0.017 15.1 0.0 0.052 13.5 0.0 1.9 1 0 0 1 1 1 0 NACHT domain AAA_16 PF13191.6 ETO21592.1 - 0.017 15.5 0.0 0.049 14.0 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ETO21592.1 - 0.023 14.7 0.0 0.098 12.6 0.0 2.1 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO21592.1 - 0.024 14.9 0.0 1.1 9.6 0.0 3.2 4 1 0 4 4 4 0 AAA domain DUF2183 PF09949.9 ETO21592.1 - 0.031 14.6 0.6 6.7 7.1 0.0 3.4 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2183) AAA_18 PF13238.6 ETO21592.1 - 0.033 14.7 0.1 0.2 12.2 0.1 2.4 1 1 0 1 1 1 0 AAA domain DOMON PF03351.17 ETO21593.1 - 3.4e-06 27.3 1.0 5.7e-06 26.6 1.0 1.4 1 0 0 1 1 1 1 DOMON domain DUF1418 PF07214.12 ETO21593.1 - 0.056 13.3 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1418) LapA_dom PF06305.11 ETO21593.1 - 0.22 11.4 1.3 1.5 8.7 0.1 2.3 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain AAA PF00004.29 ETO21594.1 - 1.9e-37 128.7 0.0 4.8e-37 127.3 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO21594.1 - 4.4e-07 29.6 0.0 1.1e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ETO21594.1 - 2.9e-06 27.2 0.0 8.4e-06 25.7 0.0 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain RuvB_N PF05496.12 ETO21594.1 - 1.5e-05 24.8 0.0 3.4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_5 PF07728.14 ETO21594.1 - 0.0011 19.0 0.0 0.006 16.6 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETO21594.1 - 0.0021 18.2 0.3 0.007 16.5 0.0 2.2 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO21594.1 - 0.0029 17.9 0.2 1.2 9.4 0.0 2.7 1 1 1 2 2 2 1 AAA domain Mg_chelatase PF01078.21 ETO21594.1 - 0.0062 15.9 0.6 0.014 14.7 0.0 1.9 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ETO21594.1 - 0.01 15.1 0.0 0.027 13.7 0.0 1.7 1 0 0 1 1 1 0 TIP49 P-loop domain TniB PF05621.11 ETO21594.1 - 0.021 14.2 0.0 1 8.7 0.0 2.7 1 1 1 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 ETO21594.1 - 0.027 14.9 0.1 0.85 10.0 0.0 2.5 1 1 1 2 2 2 0 AAA ATPase domain AAA_14 PF13173.6 ETO21594.1 - 0.037 14.1 0.0 0.12 12.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain Myco_arth_vir_N PF09610.10 ETO21594.1 - 0.96 9.6 4.7 2.9 8.1 4.7 1.7 1 0 0 1 1 1 0 Mycoplasma virulence signal region (Myco_arth_vir_N) Shisa PF13908.6 ETO21595.1 - 0.088 13.0 0.2 0.088 13.0 0.2 2.4 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator Sigma70_ner PF04546.13 ETO21595.1 - 0.39 10.6 23.4 0.085 12.7 12.1 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region Uds1 PF15456.6 ETO21595.1 - 2.7 8.2 18.9 2.4 8.3 6.7 2.3 2 0 0 2 2 2 0 Up-regulated During Septation YqeY PF09424.10 ETO21595.1 - 3.7 7.6 14.9 3.1 7.9 3.5 3.4 3 1 0 3 3 3 0 Yqey-like protein PBP1_TM PF14812.6 ETO21595.1 - 8.7 6.8 12.9 30 5.1 12.9 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pex14_N PF04695.13 ETO21595.1 - 9.5 6.9 14.2 11 6.7 7.4 2.9 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CDC45 PF02724.14 ETO21596.1 - 0.00042 18.8 5.7 0.00042 18.8 5.7 3.8 4 1 0 4 4 4 2 CDC45-like protein Secretin_N_2 PF07655.13 ETO21596.1 - 0.0062 17.1 8.5 0.0062 17.1 8.5 3.4 3 0 0 3 3 3 1 Secretin N-terminal domain FAM176 PF14851.6 ETO21597.1 - 0.038 13.7 0.2 0.063 12.9 0.2 1.3 1 0 0 1 1 1 0 FAM176 family Sec7 PF01369.20 ETO21597.1 - 0.065 12.9 3.5 0.17 11.5 3.5 1.7 1 1 0 1 1 1 0 Sec7 domain TMEM126 PF07114.11 ETO21597.1 - 0.16 11.4 0.4 0.23 10.8 0.4 1.2 1 0 0 1 1 1 0 Transmembrane protein 126 GREB1 PF15782.5 ETO21598.1 - 0.021 12.0 7.6 0.024 11.8 7.6 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer BUD22 PF09073.10 ETO21598.1 - 0.039 13.3 22.2 0.055 12.8 22.2 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 ETO21598.1 - 1.1 8.5 36.7 0.92 8.8 17.8 2.7 3 0 0 3 3 3 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 ETO21598.1 - 7.7 6.7 33.0 2.3 8.4 22.6 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 Zip PF02535.22 ETO21598.1 - 7.9 5.6 11.5 10 5.3 0.2 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter FA_desaturase PF00487.24 ETO21599.1 - 1.8e-14 54.2 6.5 2.3e-14 53.8 6.5 1.1 1 0 0 1 1 1 1 Fatty acid desaturase Asparaginase_2 PF01112.18 ETO21600.1 - 4.6e-83 278.8 0.9 4.2e-71 239.5 0.6 2.1 2 0 0 2 2 2 2 Asparaginase DUF3896 PF13035.6 ETO21600.1 - 0.83 9.9 3.7 15 5.9 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3896) Peptidase_M16_C PF05193.21 ETO21601.1 - 0.0001 22.4 0.0 0.00018 21.6 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Amastin PF07344.11 ETO21602.1 - 0.22 11.4 0.4 1 9.2 0.1 1.9 2 0 0 2 2 2 0 Amastin surface glycoprotein Kelch_4 PF13418.6 ETO21604.1 - 0.0013 18.7 1.6 0.0055 16.7 0.1 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO21604.1 - 0.036 14.1 2.2 1.6 8.8 0.0 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO21604.1 - 0.16 12.3 0.1 6.6 7.2 0.0 3.1 2 0 0 2 2 2 0 Kelch motif zf-MYND PF01753.18 ETO21605.1 - 3.5e-09 36.6 13.1 7.6e-09 35.5 13.1 1.6 1 0 0 1 1 1 1 MYND finger PolC_DP2 PF03833.13 ETO21605.1 - 0.27 9.0 7.8 0.35 8.7 7.8 1.1 1 0 0 1 1 1 0 DNA polymerase II large subunit DP2 Phage_sheath_1C PF17482.2 ETO21606.1 - 0.036 14.0 0.2 0.058 13.4 0.2 1.3 1 0 0 1 1 1 0 Phage tail sheath C-terminal domain MtaB PF12176.8 ETO21606.1 - 0.1 11.4 1.6 0.16 10.7 1.2 1.5 1 1 1 2 2 2 0 Methanol-cobalamin methyltransferase B subunit Syntaxin-18_N PF10496.9 ETO21606.1 - 0.13 12.5 0.2 0.13 12.5 0.2 2.0 1 1 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Uds1 PF15456.6 ETO21606.1 - 0.82 9.8 5.6 0.5 10.5 3.5 1.6 1 1 1 2 2 2 0 Up-regulated During Septation Complex1_LYR_2 PF13233.6 ETO21606.1 - 3.7 8.4 7.3 1.6 9.5 3.5 2.1 1 1 1 2 2 2 0 Complex1_LYR-like B56 PF01603.20 ETO21607.1 - 2.8e-55 188.0 6.2 5.5e-44 150.8 0.2 2.1 2 0 0 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) KAR9 PF08580.10 ETO21608.1 - 1.5 7.2 4.6 1.9 6.9 4.6 1.1 1 0 0 1 1 1 0 Yeast cortical protein KAR9 SR-25 PF10500.9 ETO21609.1 - 0.012 15.3 2.7 0.02 14.5 2.7 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Glyco_hydro_3 PF00933.21 ETO21609.1 - 0.062 12.7 0.0 0.1 11.9 0.0 1.3 1 0 0 1 1 1 0 Glycosyl hydrolase family 3 N terminal domain DUF3446 PF11928.8 ETO21609.1 - 0.093 13.0 7.8 0.24 11.7 7.8 1.6 1 0 0 1 1 1 0 Early growth response N-terminal domain DUF4598 PF15370.6 ETO21610.1 - 0.0037 17.7 2.4 0.006 17.0 2.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4598) RPA43_OB PF17875.1 ETO21610.1 - 0.076 13.6 1.8 0.12 13.0 1.8 1.3 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I CPSF100_C PF13299.6 ETO21610.1 - 0.087 13.0 1.6 0.11 12.7 1.6 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Podoplanin PF05808.11 ETO21610.1 - 0.11 12.6 2.1 0.16 12.0 2.1 1.2 1 0 0 1 1 1 0 Podoplanin CobT PF06213.12 ETO21610.1 - 0.19 11.1 6.2 0.26 10.7 6.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Presenilin PF01080.17 ETO21610.1 - 0.33 9.7 0.6 0.35 9.6 0.6 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO21610.1 - 0.38 9.0 4.7 0.42 8.8 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1989 PF09347.10 ETO21612.1 - 0.18 11.4 0.0 4.9 6.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1989) NBD94 PF16830.5 ETO21614.1 - 0.0077 16.6 1.9 0.0091 16.4 0.4 1.8 1 1 1 2 2 2 1 Nucleotide-Binding Domain 94 of RH Nup54_57_C PF18570.1 ETO21614.1 - 0.01 15.4 0.9 0.01 15.4 0.9 2.1 3 0 0 3 3 3 0 NUP57/Nup54 C-terminal domain YabA PF06156.13 ETO21614.1 - 0.039 14.6 2.5 0.039 14.6 2.5 2.3 1 1 1 2 2 2 0 Initiation control protein YabA TolA_bind_tri PF16331.5 ETO21614.1 - 0.048 13.7 5.2 0.11 12.6 5.2 1.6 1 1 0 1 1 1 0 TolA binding protein trimerisation DMPK_coil PF08826.10 ETO21614.1 - 0.27 11.4 6.3 1.5 9.0 0.1 2.9 3 0 0 3 3 3 0 DMPK coiled coil domain like DUF4175 PF13779.6 ETO21614.1 - 0.38 8.6 6.4 0.46 8.3 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) TMF_DNA_bd PF12329.8 ETO21614.1 - 3.8 7.6 9.8 0.26 11.3 1.2 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding FXMRP1_C_core PF12235.8 ETO21615.1 - 0.39 11.4 3.9 1 10.0 0.1 2.1 2 0 0 2 2 2 0 Fragile X-related 1 protein core C terminal XRCC4 PF06632.12 ETO21615.1 - 0.74 8.6 9.7 0.22 10.3 1.2 2.0 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 DUF733 PF05306.11 ETO21615.1 - 2.7 8.4 8.2 0.42 11.0 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF733) SecY PF00344.20 ETO21616.1 - 6.5e-30 104.4 2.0 7.7e-30 104.2 2.0 1.0 1 0 0 1 1 1 1 SecY translocase TctB PF07331.11 ETO21616.1 - 1.1 9.6 6.2 3 8.1 0.4 2.2 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family DUF2975 PF11188.8 ETO21616.1 - 1.6 8.7 7.8 0.73 9.7 0.7 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF2975) Cupin_4 PF08007.12 ETO21617.1 - 3.8e-10 39.7 0.1 4.6e-10 39.5 0.1 1.1 1 0 0 1 1 1 1 Cupin superfamily protein Cupin_8 PF13621.6 ETO21617.1 - 8.8e-10 38.7 0.2 1.8e-09 37.7 0.2 1.5 1 1 0 1 1 1 1 Cupin-like domain Cupin_2 PF07883.11 ETO21617.1 - 0.087 12.6 0.1 0.31 10.8 0.0 2.0 3 0 0 3 3 3 0 Cupin domain JmjC PF02373.22 ETO21617.1 - 0.1 13.0 0.8 0.33 11.4 0.1 2.2 2 1 0 2 2 2 0 JmjC domain, hydroxylase Hamartin PF04388.12 ETO21618.1 - 0.0029 16.4 16.8 0.0036 16.1 16.8 1.1 1 0 0 1 1 1 1 Hamartin protein Ndc1_Nup PF09531.10 ETO21618.1 - 0.039 12.7 9.3 0.043 12.5 9.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Myc_N PF01056.18 ETO21618.1 - 0.059 13.3 20.0 0.081 12.8 20.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region DUF4682 PF15733.5 ETO21618.1 - 0.078 13.6 15.5 0.19 12.3 15.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4682) TFIIA PF03153.13 ETO21618.1 - 0.17 11.9 20.2 0.22 11.5 20.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 ETO21618.1 - 0.58 9.4 10.0 1.1 8.5 10.0 1.4 1 0 0 1 1 1 0 NOA36 protein Cwf_Cwc_15 PF04889.12 ETO21618.1 - 0.6 9.8 21.1 0.91 9.2 21.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC27 PF09507.10 ETO21618.1 - 0.97 8.8 29.7 1.6 8.0 29.7 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 ASD2 PF08687.11 ETO21618.1 - 1.1 8.7 19.8 2 7.9 19.8 1.4 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 DUF4551 PF15087.6 ETO21618.1 - 2.1 7.1 18.2 2.9 6.6 18.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Dicty_REP PF05086.12 ETO21618.1 - 2.2 6.1 18.8 3.3 5.6 18.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LAP1C PF05609.12 ETO21618.1 - 2.6 7.1 22.4 3.9 6.4 22.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF966 PF06136.13 ETO21618.1 - 4.5 6.9 18.2 6.8 6.3 18.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Presenilin PF01080.17 ETO21618.1 - 8.9 5.0 19.5 17 4.1 19.5 1.4 1 0 0 1 1 1 0 Presenilin Protocadherin PF08374.11 ETO21618.1 - 9.4 6.1 18.5 8 6.4 16.0 1.9 1 1 1 2 2 2 0 Protocadherin LAP1C PF05609.12 ETO21620.1 - 0.00018 20.8 0.5 0.00025 20.3 0.5 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) LMBR1 PF04791.16 ETO21620.1 - 0.018 14.0 2.4 0.021 13.7 2.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Hid1 PF12722.7 ETO21620.1 - 0.51 8.4 6.0 0.61 8.1 6.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Shisa PF13908.6 ETO21620.1 - 0.54 10.5 7.9 0.04 14.2 1.5 2.1 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator Menin PF05053.13 ETO21620.1 - 0.93 7.8 4.3 0.97 7.7 4.3 1.0 1 0 0 1 1 1 0 Menin GNAT_acetyltr_2 PF13718.6 ETO21620.1 - 1.5 8.2 9.2 0.21 10.9 4.4 1.8 2 0 0 2 2 2 0 GNAT acetyltransferase 2 DUF3464 PF11947.8 ETO21620.1 - 2 8.2 10.9 14 5.4 0.0 2.1 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 MAS20 PF02064.15 ETO21620.1 - 3.6 7.7 8.7 31 4.7 5.2 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor SUIM_assoc PF16619.5 ETO21621.1 - 0.0041 17.2 4.9 0.0044 17.0 1.2 2.9 2 1 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 WD40 PF00400.32 ETO21622.1 - 0.00018 22.2 0.1 0.00091 20.0 0.1 2.1 2 1 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO21623.1 - 5.8e-06 27.0 3.8 0.0016 19.2 0.1 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO21623.1 - 0.052 12.2 0.1 0.085 11.5 0.1 1.3 1 0 0 1 1 1 0 Nucleoporin Nup120/160 NACHT PF05729.12 ETO21624.1 - 2.7e-18 66.4 0.0 6.3e-18 65.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain RTP1_C1 PF10363.9 ETO21624.1 - 0.13 12.4 0.1 0.46 10.7 0.1 2.0 1 0 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF2746 PF10874.8 ETO21624.1 - 0.15 12.5 0.6 23 5.5 0.1 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2746) NLRC4_HD2 PF17776.1 ETO21624.1 - 0.18 12.3 0.1 0.18 12.3 0.1 3.9 4 1 0 4 4 4 0 NLRC4 helical domain HD2 PH PF00169.29 ETO21625.1 - 9.5e-06 26.1 0.1 0.00021 21.8 0.0 2.6 2 0 0 2 2 2 1 PH domain PID_2 PF14719.6 ETO21625.1 - 0.013 15.4 0.0 0.025 14.4 0.0 1.5 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF3439 PF11921.8 ETO21626.1 - 1.4 8.9 13.6 3.5 7.6 13.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) TP2 PF01254.18 ETO21626.1 - 1.4 9.5 13.1 3.8 8.1 13.1 1.7 1 1 0 1 1 1 0 Nuclear transition protein 2 HDA2-3 PF11496.8 ETO21628.1 - 0.2 10.8 7.8 0.22 10.7 7.8 1.2 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 CUE PF02845.16 ETO21629.1 - 2.3e-11 43.2 0.4 1.3e-06 27.9 0.1 2.4 2 0 0 2 2 2 2 CUE domain PUB PF09409.10 ETO21629.1 - 7.9e-05 22.5 0.1 0.0018 18.2 0.0 2.2 2 0 0 2 2 2 1 PUB domain DMA PF03474.14 ETO21629.1 - 0.00014 21.3 0.1 0.049 13.2 0.0 2.8 3 0 0 3 3 3 2 DMRTA motif HTH_8 PF02954.19 ETO21629.1 - 0.0046 16.7 0.0 0.066 13.0 0.0 2.4 2 0 0 2 2 2 1 Bacterial regulatory protein, Fis family Adenine_glyco PF03352.13 ETO21629.1 - 0.052 13.3 0.0 0.083 12.7 0.0 1.5 1 1 0 1 1 1 0 Methyladenine glycosylase zf-RING_2 PF13639.6 ETO21630.1 - 3.5e-12 46.5 11.9 3.5e-12 46.5 11.9 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO21630.1 - 1.2e-08 34.7 12.0 1.2e-08 34.7 12.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO21630.1 - 2.7e-08 33.4 6.8 5.5e-08 32.4 5.8 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4 PF00097.25 ETO21630.1 - 7.3e-07 29.0 10.8 7.3e-07 29.0 10.8 2.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO21630.1 - 5.1e-06 26.7 13.4 5.1e-06 26.7 13.4 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETO21630.1 - 2.6e-05 24.1 6.8 2.6e-05 24.1 6.8 1.9 1 1 1 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO21630.1 - 2.9e-05 23.8 7.3 2.9e-05 23.8 7.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO21630.1 - 5.5e-05 23.1 4.8 0.00012 22.0 4.8 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_9 PF14369.6 ETO21630.1 - 0.00021 21.5 0.6 0.00021 21.5 0.6 3.3 3 0 0 3 3 3 1 zinc-ribbon zf-RING_5 PF14634.6 ETO21630.1 - 0.00099 19.0 9.2 0.00099 19.0 9.2 2.4 2 1 0 3 3 3 1 zinc-RING finger domain Rad50_zn_hook PF04423.14 ETO21630.1 - 0.0014 18.5 2.3 0.16 11.8 0.0 3.3 3 0 0 3 3 3 1 Rad50 zinc hook motif Zn-C2H2_12 PF18112.1 ETO21630.1 - 0.0046 17.4 1.5 1 9.9 0.2 2.7 2 0 0 2 2 2 1 Autophagy receptor zinc finger-C2H2 domain Prok-RING_4 PF14447.6 ETO21630.1 - 0.028 14.3 18.4 0.18 11.7 6.3 3.1 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 zf-C4 PF00105.18 ETO21630.1 - 0.1 13.1 6.4 0.7 10.4 1.4 2.5 2 0 0 2 2 2 0 Zinc finger, C4 type (two domains) zf-Nse PF11789.8 ETO21630.1 - 0.65 9.9 5.4 1.5 8.7 5.4 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit UBZ_FAAP20 PF15750.5 ETO21630.1 - 0.77 9.8 5.0 7.6 6.6 0.0 3.4 4 0 0 4 4 4 0 Ubiquitin-binding zinc-finger Prok-RING_1 PF14446.6 ETO21630.1 - 0.95 9.4 15.5 10 6.1 3.6 3.3 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Zn_ribbon_17 PF17120.5 ETO21630.1 - 2.1 8.0 14.0 0.73 9.5 6.8 2.4 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type SLC12 PF03522.15 ETO21630.1 - 2.5 7.0 13.3 1.6 7.7 9.7 2.1 2 0 0 2 2 2 0 Solute carrier family 12 zinc-ribbons_6 PF07191.12 ETO21630.1 - 2.8 8.0 11.8 7.3 6.7 5.4 2.4 2 0 0 2 2 2 0 zinc-ribbons zf-RING_4 PF14570.6 ETO21630.1 - 5.3 6.9 16.3 0.27 11.1 9.3 2.3 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain HypA PF01155.19 ETO21630.1 - 6.8 6.7 7.1 5 7.2 0.4 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Bromodomain PF00439.25 ETO21632.1 - 1.7e-07 31.2 0.2 1.9e-06 27.9 0.1 2.3 2 0 0 2 2 2 1 Bromodomain Mucin PF01456.17 ETO21632.1 - 0.00046 20.2 0.2 0.00046 20.2 0.2 2.9 3 0 0 3 3 3 1 Mucin-like glycoprotein Serglycin PF04360.12 ETO21632.1 - 0.0098 15.8 0.4 0.0098 15.8 0.4 2.6 3 0 0 3 3 3 1 Serglycin DUF3439 PF11921.8 ETO21632.1 - 0.96 9.4 12.7 0.039 13.9 5.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO21632.1 - 3.9 5.3 15.1 0.057 11.4 5.1 2.1 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein DUF4050 PF13259.6 ETO21633.1 - 0.061 13.6 10.8 0.083 13.2 10.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) NPAT_C PF15712.5 ETO21633.1 - 0.28 9.8 11.8 0.33 9.5 11.8 1.0 1 0 0 1 1 1 0 NPAT C terminus Hydin_ADK PF17213.3 ETO21633.1 - 3 8.1 8.2 3.5 7.8 8.2 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain NPR3 PF03666.13 ETO21633.1 - 8.9 5.0 14.8 8.7 5.0 14.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO21634.1 - 0.074 11.4 24.7 0.0092 14.4 16.5 2.1 2 0 0 2 2 2 0 Menin FSA_C PF10479.9 ETO21634.1 - 0.21 9.7 8.8 0.37 8.9 8.8 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CENP-B_dimeris PF09026.10 ETO21634.1 - 2.1 8.8 15.8 1.9 8.9 4.6 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Tom22 PF04281.13 ETO21634.1 - 6.5 6.5 13.0 2.6 7.8 1.9 2.4 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 SRP54 PF00448.22 ETO21636.1 - 0.0095 15.6 0.7 0.017 14.8 0.7 1.3 1 0 0 1 1 1 1 SRP54-type protein, GTPase domain Menin PF05053.13 ETO21636.1 - 0.03 12.7 15.5 0.035 12.5 15.5 1.2 1 0 0 1 1 1 0 Menin DDE_Tnp_IS66_C PF13817.6 ETO21636.1 - 0.076 13.3 0.1 0.18 12.0 0.1 1.6 1 0 0 1 1 1 0 IS66 C-terminal element PspB PF06667.12 ETO21636.1 - 2.4 8.3 7.6 16 5.6 0.3 2.6 2 0 0 2 2 2 0 Phage shock protein B LAP1C PF05609.12 ETO21636.1 - 2.7 7.0 23.4 3.4 6.7 23.4 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) LMBR1 PF04791.16 ETO21636.1 - 2.8 6.7 13.7 3.6 6.4 13.7 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 ETO21636.1 - 3.1 7.1 18.7 0.1 11.9 12.9 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) SR-25 PF10500.9 ETO21636.1 - 5.7 6.5 28.4 1.2 8.6 5.3 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein Exostosin PF03016.15 ETO21637.1 - 1.6e-06 27.5 0.0 5.6e-06 25.8 0.0 1.7 1 1 0 2 2 2 1 Exostosin family Enkurin PF13864.6 ETO21637.1 - 0.0082 16.6 1.7 0.011 16.1 0.3 1.9 2 0 0 2 2 2 1 Calmodulin-binding RNase_H2_suC PF08615.11 ETO21638.1 - 1.7 8.8 10.8 11 6.2 10.7 2.1 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Ribosomal_S17_N PF16205.5 ETO21638.1 - 2.6 8.5 9.1 0.52 10.7 3.9 2.4 1 1 1 2 2 2 0 Ribosomal_S17 N-terminal EVI2A PF05399.11 ETO21638.1 - 3.7 7.1 5.3 4.2 6.9 5.3 1.0 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Ndc1_Nup PF09531.10 ETO21638.1 - 8.8 4.9 10.3 9.9 4.7 10.3 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Pex14_N PF04695.13 ETO21638.1 - 9.6 6.8 16.5 11 6.7 16.0 1.3 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4456 PF14644.6 ETO21639.1 - 0.0023 17.7 4.6 0.0042 16.8 4.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4456) ALMT PF11744.8 ETO21639.1 - 5 5.8 7.7 5.7 5.7 7.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Archease PF01951.16 ETO21640.1 - 0.092 13.0 0.2 0.16 12.2 0.2 1.3 1 0 0 1 1 1 0 Archease protein family (MTH1598/TM1083) Ycf1 PF05758.12 ETO21641.1 - 0.026 12.4 1.0 0.032 12.1 1.0 1.0 1 0 0 1 1 1 0 Ycf1 DUF2207 PF09972.9 ETO21641.1 - 0.043 12.6 0.7 0.05 12.4 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Jiraiya PF15038.6 ETO21641.1 - 0.11 11.9 4.3 0.23 10.9 0.0 2.1 2 0 0 2 2 2 0 Jiraiya TMEM156 PF15106.6 ETO21641.1 - 0.36 10.2 3.0 0.2 11.1 0.6 1.7 1 1 1 2 2 2 0 TMEM156 protein family RGS PF00615.19 ETO21642.1 - 5.1e-11 42.9 1.5 8.5e-11 42.2 1.5 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DENN PF02141.21 ETO21643.1 - 1.2e-10 41.7 1.6 1.8e-10 41.1 0.8 1.7 2 0 0 2 2 2 1 DENN (AEX-3) domain uDENN PF03456.18 ETO21643.1 - 0.0043 17.8 0.1 0.017 15.9 0.0 2.1 2 0 0 2 2 2 1 uDENN domain NB-ARC PF00931.22 ETO21643.1 - 0.094 11.9 0.0 0.18 11.0 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain Ground-like PF04155.18 ETO21644.1 - 0.13 12.9 1.0 0.49 11.1 0.0 2.2 2 0 0 2 2 2 0 Ground-like domain DUF569 PF04601.13 ETO21645.1 - 0.008 15.9 0.2 0.017 14.8 0.0 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF569) Minor_capsid_3 PF12691.7 ETO21645.1 - 0.043 14.2 0.2 0.083 13.3 0.2 1.5 1 0 0 1 1 1 0 Minor capsid protein from bacteriophage DUF2914 PF11141.8 ETO21645.1 - 0.056 13.2 0.1 0.18 11.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2914) TPPII PF12580.8 ETO21645.1 - 0.08 12.4 0.3 0.15 11.5 0.3 1.4 1 0 0 1 1 1 0 Tripeptidyl peptidase II zf-ZPR1 PF03367.13 ETO21645.1 - 0.081 12.8 0.5 0.14 12.0 0.5 1.4 1 0 0 1 1 1 0 ZPR1 zinc-finger domain FAM177 PF14774.6 ETO21645.1 - 0.4 11.1 3.6 4.5 7.7 0.1 2.3 2 0 0 2 2 2 0 FAM177 family DUF4710 PF15828.5 ETO21645.1 - 1.3 9.2 8.4 5.8 7.1 4.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Paramyxo_ncap PF00973.19 ETO21646.1 - 1 8.2 8.3 0.25 10.2 0.6 2.2 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein Usp PF00582.26 ETO21647.1 - 0.014 15.9 0.7 2.1 8.9 0.2 2.3 2 0 0 2 2 2 0 Universal stress protein family P22_AR_C PF10548.9 ETO21647.1 - 0.065 13.4 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 P22AR C-terminal domain DUF2063 PF09836.9 ETO21647.1 - 0.068 13.4 1.0 6.4 7.1 0.0 2.3 2 0 0 2 2 2 0 Putative DNA-binding domain Ank_4 PF13637.6 ETO21648.1 - 0.038 14.6 0.0 8.1 7.2 0.0 2.8 2 1 0 2 2 2 0 Ankyrin repeats (many copies) ArsC PF03960.15 ETO21648.1 - 0.062 13.3 0.0 0.12 12.4 0.0 1.3 1 1 0 1 1 1 0 ArsC family Ank_2 PF12796.7 ETO21649.1 - 4.8e-12 46.3 0.2 0.012 16.2 0.1 4.3 2 1 3 5 5 5 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO21649.1 - 1.7e-08 34.8 2.7 3.7e-05 24.2 0.5 4.4 5 0 0 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21649.1 - 9.1e-07 28.7 3.5 4.8 8.1 0.1 6.1 7 0 0 7 7 7 2 Ankyrin repeat Ank PF00023.30 ETO21649.1 - 1.5e-06 28.4 3.0 0.66 10.5 0.1 5.3 6 0 0 6 6 6 2 Ankyrin repeat Ank_5 PF13857.6 ETO21649.1 - 0.0062 16.8 1.8 1.4 9.3 0.1 3.9 4 0 0 4 4 4 1 Ankyrin repeats (many copies) DUF2207 PF09972.9 ETO21649.1 - 0.19 10.5 0.7 0.23 10.2 0.7 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF4079 PF13301.6 ETO21650.1 - 0.0061 16.7 2.3 0.025 14.7 0.3 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF4079) DUF3464 PF11947.8 ETO21650.1 - 0.049 13.4 2.8 0.2 11.4 0.0 2.4 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 OAD_gamma PF04277.13 ETO21650.1 - 0.072 13.7 0.3 0.072 13.7 0.3 3.3 4 1 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain COX7B PF05392.11 ETO21650.1 - 0.089 12.5 0.3 0.089 12.5 0.3 2.1 2 0 0 2 2 2 0 Cytochrome C oxidase chain VIIB SARAF PF06682.12 ETO21650.1 - 0.3 10.7 2.8 3.6 7.1 0.3 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Secretin_N_2 PF07655.13 ETO21651.1 - 0.87 10.2 8.5 1.6 9.3 8.5 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain WD40 PF00400.32 ETO21653.1 - 1.3e-05 25.9 1.9 0.015 16.2 0.2 2.5 2 1 0 2 2 2 2 WD domain, G-beta repeat CRT10 PF08728.10 ETO21653.1 - 0.0032 15.7 0.2 0.0037 15.5 0.2 1.0 1 0 0 1 1 1 1 CRT10 CDT1 PF08839.11 ETO21655.1 - 7.3e-09 36.2 2.1 8.7e-09 35.9 0.2 2.0 2 0 0 2 2 2 1 DNA replication factor CDT1 like CDT1_C PF16679.5 ETO21656.1 - 3.9e-07 30.4 0.1 5.1e-07 30.0 0.1 1.2 1 0 0 1 1 1 1 DNA replication factor Cdt1 C-terminal domain DUF261 PF03196.13 ETO21656.1 - 0.018 15.2 0.3 0.026 14.6 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function, DUF261 DUF4359 PF14271.6 ETO21657.1 - 0.83 10.5 5.5 1.1 10.0 2.9 2.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4359) Aldedh PF00171.22 ETO21657.1 - 1.6 7.1 5.7 1.9 6.9 3.9 1.8 1 1 1 2 2 2 0 Aldehyde dehydrogenase family Filament PF00038.21 ETO21657.1 - 1.6 8.2 57.3 11 5.5 23.6 2.6 1 1 1 2 2 2 0 Intermediate filament protein Pkinase PF00069.25 ETO21658.1 - 1.2e-15 57.6 0.0 1.4e-15 57.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21658.1 - 3.2e-08 33.2 0.0 4e-08 32.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase SmaI PF17411.2 ETO21658.1 - 0.14 11.3 0.0 0.15 11.2 0.0 1.1 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease Pkinase PF00069.25 ETO21659.1 - 6.5e-48 163.4 0.4 8e-48 163.1 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21659.1 - 1.6e-32 112.8 0.1 1.9e-32 112.6 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO21659.1 - 0.0024 17.8 2.5 0.049 13.5 0.5 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family FTA2 PF13095.6 ETO21659.1 - 0.0044 16.7 0.5 0.16 11.5 0.0 2.4 2 0 0 2 2 2 1 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ETO21659.1 - 0.0045 16.4 1.1 0.0077 15.6 1.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO21659.1 - 0.0065 15.8 0.0 0.17 11.2 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ETO21659.1 - 0.0069 15.4 0.4 0.013 14.5 0.4 1.5 1 1 0 1 1 1 1 Haspin like kinase domain Seadorna_VP7 PF07387.11 ETO21659.1 - 0.047 12.7 0.0 0.073 12.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 DNA_pol_A_exo1 PF01612.20 ETO21660.1 - 1.8e-12 47.3 0.1 3.2e-12 46.5 0.1 1.3 1 1 0 1 1 1 1 3'-5' exonuclease DUF5056 PF16479.5 ETO21662.1 - 0.14 12.4 0.1 0.14 12.4 0.1 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5056) ABC2_membrane_3 PF12698.7 ETO21662.1 - 0.19 10.8 1.3 0.36 9.9 1.3 1.7 1 1 0 1 1 1 0 ABC-2 family transporter protein Orf78 PF06024.12 ETO21662.1 - 1.5 9.2 6.9 0.5 10.7 0.4 2.8 2 1 1 3 3 3 0 Orf78 (ac78) Ctr PF04145.15 ETO21663.1 - 0.97 10.0 5.0 7.8 7.1 0.3 2.4 2 0 0 2 2 2 0 Ctr copper transporter family MgtE PF01769.16 ETO21665.1 - 4.3 7.8 6.5 6.7 7.1 6.5 1.3 1 0 0 1 1 1 0 Divalent cation transporter Beta_helix PF13229.6 ETO21666.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Right handed beta helix region FAM199X PF15814.5 ETO21667.1 - 0.093 11.8 3.3 0.13 11.2 3.3 1.2 1 0 0 1 1 1 0 Protein family FAM199X Fijivirus_P9-2 PF06837.11 ETO21668.1 - 0.037 13.5 2.3 0.043 13.3 2.3 1.1 1 0 0 1 1 1 0 Fijivirus P9-2 protein TPR_12 PF13424.6 ETO21669.1 - 1.9e-53 178.7 14.2 1.8e-14 53.8 0.0 5.5 2 2 4 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO21669.1 - 4.9e-41 137.5 1.4 5.3e-09 35.7 0.0 7.9 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21669.1 - 8.5e-26 88.0 27.8 1.3e-05 24.9 0.9 7.5 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO21669.1 - 9.1e-26 88.6 37.6 1e-06 28.3 2.2 7.4 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21669.1 - 4.3e-25 85.8 33.0 3.3e-05 23.7 0.2 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO21669.1 - 3.5e-24 83.0 7.8 2.2e-06 27.3 0.1 7.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO21669.1 - 1.3e-09 38.0 7.0 0.43 11.3 0.1 5.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO21669.1 - 1.5e-08 34.1 18.8 0.18 11.5 0.4 6.7 6 0 0 6 6 6 3 TPR repeat TPR_17 PF13431.6 ETO21669.1 - 5.2e-08 32.7 10.5 0.83 10.2 0.5 6.7 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO21669.1 - 5.7e-08 33.2 0.1 0.041 14.4 0.1 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO21669.1 - 6.5e-08 32.3 0.0 0.0037 16.7 0.0 3.1 2 1 1 3 3 3 2 MalT-like TPR region TPR_14 PF13428.6 ETO21669.1 - 2.6e-07 30.9 0.1 2.5 9.1 0.0 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO21669.1 - 1.8e-06 28.5 0.0 0.34 11.6 0.0 5.0 4 2 0 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO21669.1 - 0.00068 19.8 8.7 0.091 13.0 0.8 4.1 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO21669.1 - 0.00079 19.4 21.8 0.18 11.8 0.3 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO21669.1 - 0.0063 16.6 0.0 1.8 8.8 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO21669.1 - 0.0078 15.7 1.8 7.8 6.0 0.0 4.3 4 0 0 4 4 4 1 SHNi-TPR BSP_II PF05432.11 ETO21669.1 - 0.017 14.8 2.9 0.026 14.2 2.9 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF5113 PF17140.4 ETO21669.1 - 0.018 14.8 10.8 0.87 9.4 0.3 5.4 3 1 3 6 6 6 0 Domain of unknown function (DUF5113) PPR PF01535.20 ETO21669.1 - 0.22 11.8 5.6 63 4.1 0.0 5.0 4 0 0 4 4 4 0 PPR repeat HTH_Bact PF18768.1 ETO21669.1 - 0.55 9.9 12.2 13 5.4 3.7 5.7 5 1 0 5 5 5 0 Helix-turn-helix bacterial domain Fis1_TPR_C PF14853.6 ETO21669.1 - 8.8 6.5 15.0 2.5 8.2 0.4 4.9 5 0 0 5 5 5 0 Fis1 C-terminal tetratricopeptide repeat ETF PF01012.21 ETO21670.1 - 1.9e-36 125.6 0.3 2.6e-36 125.2 0.3 1.2 1 0 0 1 1 1 1 Electron transfer flavoprotein domain ETF_alpha PF00766.19 ETO21670.1 - 1.5e-34 117.9 1.7 2.3e-34 117.3 0.6 1.9 2 0 0 2 2 2 1 Electron transfer flavoprotein FAD-binding domain Microvir_H PF04687.12 ETO21671.1 - 0.061 12.7 0.5 0.082 12.3 0.5 1.2 1 0 0 1 1 1 0 Microvirus H protein (pilot protein) ABC_tran PF00005.27 ETO21672.1 - 5e-25 88.6 0.0 9.2e-25 87.8 0.0 1.5 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO21672.1 - 1.4e-05 24.7 0.0 0.09 12.2 0.0 2.1 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO21672.1 - 4e-05 23.6 3.4 0.13 12.1 0.0 2.7 3 1 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system NACHT PF05729.12 ETO21672.1 - 0.0015 18.4 0.0 0.22 11.4 0.0 3.2 2 1 1 3 3 3 1 NACHT domain DUF87 PF01935.17 ETO21672.1 - 0.0024 18.0 0.1 0.0047 17.0 0.1 1.4 1 0 0 1 1 1 1 Helicase HerA, central domain AAA_15 PF13175.6 ETO21672.1 - 0.0097 15.7 0.0 0.024 14.4 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO21672.1 - 0.016 14.9 1.5 0.038 13.7 0.9 1.8 1 1 1 2 2 2 0 P-loop containing region of AAA domain RNA_helicase PF00910.22 ETO21672.1 - 0.02 15.3 0.2 1.3 9.4 0.0 3.2 3 1 0 3 3 3 0 RNA helicase AAA_22 PF13401.6 ETO21672.1 - 0.021 15.1 0.0 0.34 11.2 0.0 2.5 1 1 1 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO21672.1 - 0.034 14.5 0.0 0.057 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain NB-ARC PF00931.22 ETO21672.1 - 0.06 12.5 0.1 0.13 11.4 0.0 1.6 2 0 0 2 2 2 0 NB-ARC domain MeaB PF03308.16 ETO21672.1 - 0.073 12.0 0.0 0.11 11.5 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ETO21672.1 - 0.1 12.7 0.0 0.21 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF815 PF05673.13 ETO21672.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PIN PF01850.21 ETO21672.1 - 0.11 13.0 0.0 0.2 12.2 0.0 1.4 1 0 0 1 1 1 0 PIN domain RsgA_GTPase PF03193.16 ETO21672.1 - 0.13 12.2 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ALMT PF11744.8 ETO21673.1 - 0.22 10.3 14.5 0.3 9.9 14.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Paf1 PF03985.13 ETO21673.1 - 0.24 10.4 25.1 0.34 9.9 25.1 1.1 1 0 0 1 1 1 0 Paf1 CDC45 PF02724.14 ETO21673.1 - 0.81 7.9 18.3 1 7.5 18.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO21673.1 - 0.95 7.5 27.1 1.4 6.9 27.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi RP-C_C PF11800.8 ETO21673.1 - 1 9.4 10.9 1.5 8.9 10.9 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region DDHD PF02862.17 ETO21673.1 - 2.7 8.1 6.3 4 7.5 6.3 1.3 1 0 0 1 1 1 0 DDHD domain ATP11 PF06644.11 ETO21673.1 - 3.1 7.5 20.8 0.34 10.7 13.3 2.0 2 0 0 2 2 2 0 ATP11 protein DUF913 PF06025.12 ETO21673.1 - 5.8 5.8 8.6 7.9 5.3 8.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF2457 PF10446.9 ETO21673.1 - 6.1 5.9 32.8 8.6 5.4 32.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Exonuc_VII_L PF02601.15 ETO21673.1 - 7 6.1 12.8 9.6 5.7 12.8 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pkinase PF00069.25 ETO21674.1 - 1.5e-08 34.3 0.0 2.9e-08 33.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21674.1 - 0.022 14.0 0.0 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase DUF4589 PF15252.6 ETO21676.1 - 0.11 12.5 13.2 0.04 13.9 10.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4589) DUF2967 PF11179.8 ETO21677.1 - 0.077 11.1 0.2 0.093 10.8 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) DUF4834 PF16118.5 ETO21678.1 - 0.38 11.7 1.5 3.6 8.6 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Menin PF05053.13 ETO21678.1 - 0.47 8.7 3.3 0.74 8.1 3.3 1.2 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO21678.1 - 0.5 10.9 19.7 0.15 12.6 12.8 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain SieB PF14163.6 ETO21679.1 - 0.085 12.3 3.8 0.2 11.1 3.8 1.6 1 0 0 1 1 1 0 Super-infection exclusion protein B PMSR PF01625.21 ETO21680.1 - 1.3e-44 152.1 6.0 3.7e-34 118.1 0.1 2.2 1 1 1 2 2 2 2 Peptide methionine sulfoxide reductase UCH PF00443.29 ETO21681.1 - 7.2e-31 107.6 0.0 2.8e-30 105.7 0.0 1.9 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO21681.1 - 3.8e-21 76.0 0.5 3.8e-21 76.0 0.5 2.4 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ETO21681.1 - 4.8e-14 52.7 0.9 4e-12 46.6 0.1 3.2 2 1 0 2 2 2 1 DUSP domain Zip PF02535.22 ETO21681.1 - 0.041 13.1 9.5 0.34 10.1 6.3 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter CDC45 PF02724.14 ETO21681.1 - 0.074 11.3 16.8 0.31 9.3 15.1 2.1 2 0 0 2 2 2 0 CDC45-like protein Trypan_PARP PF05887.11 ETO21681.1 - 1.8 8.6 14.6 4.6 7.2 14.6 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FAM60A PF15396.6 ETO21681.1 - 2.6 8.0 22.3 0.19 11.7 0.5 2.8 3 0 0 3 3 3 0 Protein Family FAM60A Presenilin PF01080.17 ETO21681.1 - 7.5 5.2 20.6 14 4.3 16.1 2.3 2 0 0 2 2 2 0 Presenilin DUF4200 PF13863.6 ETO21682.1 - 0.00083 19.8 0.6 0.0016 18.8 0.6 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4200) DUF4788 PF16032.5 ETO21682.1 - 0.043 12.8 0.1 0.29 10.1 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4788) DUF2369 PF10179.9 ETO21682.1 - 0.067 13.6 0.2 0.15 12.5 0.2 1.5 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2369) TGT PF01702.18 ETO21683.1 - 1.2e-05 24.6 0.1 1.4e-05 24.4 0.1 1.1 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TPR_12 PF13424.6 ETO21684.1 - 9.8e-30 102.7 5.0 6.2e-11 42.4 0.3 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO21684.1 - 2.3e-20 71.8 2.8 1.9e-06 27.5 0.1 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO21684.1 - 6.1e-18 63.5 3.2 3.2e-06 26.8 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO21684.1 - 2.1e-17 62.1 20.9 1.4e-05 24.7 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21684.1 - 2.7e-15 55.2 15.6 0.00017 21.5 0.1 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21684.1 - 7.9e-15 53.7 14.0 0.00045 20.1 0.0 4.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO21684.1 - 4.8e-06 26.6 8.9 0.077 13.4 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO21684.1 - 3.5e-05 24.2 2.5 0.98 10.2 0.2 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO21684.1 - 0.00044 20.8 0.3 15 6.3 0.1 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO21684.1 - 0.00079 20.0 0.0 14 6.8 0.0 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat MIT PF04212.18 ETO21684.1 - 0.0014 18.6 0.8 3.9 7.6 0.0 3.3 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 ETO21684.1 - 0.061 13.4 0.5 2.9 8.0 0.1 2.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) DUF627 PF04781.12 ETO21684.1 - 0.066 13.2 0.5 0.32 11.0 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF627) ANAPC3 PF12895.7 ETO21684.1 - 0.21 11.9 10.1 12 6.2 0.2 4.2 1 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETO21684.1 - 0.26 11.0 15.9 2.5 7.9 2.4 5.2 4 1 1 5 5 5 0 TPR repeat Fis1_TPR_C PF14853.6 ETO21684.1 - 0.78 9.9 4.7 17 5.6 0.2 2.8 2 0 0 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO21685.1 - 7.9e-12 45.7 3.0 3.2e-09 37.1 1.1 2.4 2 1 0 2 2 2 2 Caspase domain SIS PF01380.22 ETO21686.1 - 1.4e-35 122.0 1.7 1.8e-19 69.9 0.1 3.5 3 0 0 3 3 3 3 SIS domain GATase_6 PF13522.6 ETO21686.1 - 3.8e-19 69.2 0.0 7.5e-19 68.3 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ETO21686.1 - 1.7e-14 53.8 0.0 3.1e-14 52.9 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_4 PF13230.6 ETO21686.1 - 0.0021 17.0 0.2 0.0042 16.0 0.2 1.4 1 0 0 1 1 1 1 Glutamine amidotransferases class-II Glyco_tran_28_C PF04101.16 ETO21686.1 - 0.0052 16.8 0.0 0.057 13.4 0.0 2.3 2 0 0 2 2 2 1 Glycosyltransferase family 28 C-terminal domain NADH_oxidored PF08040.11 ETO21686.1 - 0.17 11.6 0.0 0.72 9.6 0.0 2.0 2 0 0 2 2 2 0 MNLL subunit RGS PF00615.19 ETO21687.1 - 1.8e-05 25.0 5.3 0.00023 21.4 0.5 3.3 3 0 0 3 3 3 1 Regulator of G protein signaling domain Sarcoglycan_1 PF04790.13 ETO21687.1 - 0.078 12.3 7.2 0.12 11.7 0.1 2.8 2 1 1 3 3 3 0 Sarcoglycan complex subunit protein UPF0542 PF15086.6 ETO21687.1 - 0.93 9.5 4.7 0.23 11.4 0.2 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0542 DUF2396 PF09654.10 ETO21688.1 - 0.053 13.6 0.6 0.065 13.3 0.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2396) DUF1904 PF08921.11 ETO21688.1 - 0.09 13.1 1.4 0.14 12.5 1.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1904) GntR PF00392.21 ETO21688.1 - 0.092 12.4 0.0 0.16 11.6 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family YMF19 PF02326.15 ETO21689.1 - 0.0031 18.2 0.4 0.02 15.6 0.4 2.5 1 0 0 1 1 1 1 Plant ATP synthase F0 Zip PF02535.22 ETO21689.1 - 0.021 14.0 0.1 0.047 12.9 0.1 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO21689.1 - 0.16 12.9 0.1 0.16 12.9 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) Tetraspanin PF00335.20 ETO21689.1 - 0.19 11.4 0.0 0.19 11.4 0.0 1.8 2 0 0 2 2 2 0 Tetraspanin family FliT PF05400.13 ETO21689.1 - 0.57 11.0 9.9 0.068 14.0 4.7 2.2 2 0 0 2 2 2 0 Flagellar protein FliT SID-1_RNA_chan PF13965.6 ETO21689.1 - 2.8 6.2 11.1 0.014 13.9 0.8 2.1 2 1 0 2 2 2 0 dsRNA-gated channel SID-1 MRNIP PF15749.5 ETO21690.1 - 0.00051 20.7 2.5 0.00051 20.7 2.5 3.5 3 0 0 3 3 3 1 MRN-interacting protein zf-MYND PF01753.18 ETO21690.1 - 0.036 14.2 0.7 0.036 14.2 0.7 4.4 4 0 0 4 4 4 0 MYND finger FOXP-CC PF16159.5 ETO21690.1 - 7.5 7.3 8.3 2.1 9.0 0.9 2.9 2 0 0 2 2 2 0 FOXP coiled-coil domain Kelch_1 PF01344.25 ETO21691.1 - 5.5e-05 22.7 0.1 0.00056 19.4 0.0 2.7 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO21691.1 - 0.00013 22.1 0.1 0.0054 17.0 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO21691.1 - 0.0032 17.4 0.0 0.016 15.2 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO21691.1 - 0.095 13.0 0.1 0.56 10.6 0.0 2.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO21691.1 - 0.17 11.9 1.7 1.7 8.7 0.1 2.7 2 1 0 2 2 2 0 Kelch motif Ank_2 PF12796.7 ETO21692.1 - 4.7e-10 39.9 0.4 9.3e-10 39.0 0.2 1.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO21692.1 - 4.4e-09 36.7 2.1 2.5e-07 31.1 0.1 3.4 2 2 2 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO21692.1 - 4.6e-09 36.4 1.8 7.8e-05 22.9 0.3 2.9 1 1 2 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21692.1 - 3.4e-08 33.1 0.7 0.00094 19.5 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ETO21692.1 - 0.0042 17.5 0.1 3.8 8.1 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeat DNA_pol3_a_NII PF11490.8 ETO21692.1 - 0.01 15.7 1.9 0.02 14.7 1.9 1.5 1 0 0 1 1 1 0 DNA polymerase III polC-type N-terminus II Band_7 PF01145.25 ETO21693.1 - 5.6e-06 26.5 2.9 0.00033 20.7 1.4 2.6 2 1 0 2 2 2 2 SPFH domain / Band 7 family Comm PF15957.5 ETO21693.1 - 0.013 15.9 0.8 0.41 11.0 0.0 2.4 2 0 0 2 2 2 0 Commissureless Sec62 PF03839.16 ETO21693.1 - 0.12 11.9 1.9 0.15 11.6 0.1 1.8 2 0 0 2 2 2 0 Translocation protein Sec62 La PF05383.17 ETO21694.1 - 1.8e-12 47.1 0.0 5.4e-12 45.6 0.0 1.9 1 0 0 1 1 1 1 La domain DUF3439 PF11921.8 ETO21694.1 - 0.018 15.0 1.9 0.038 14.0 1.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4609 PF15382.6 ETO21694.1 - 0.15 12.0 4.1 0.41 10.6 4.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4609) Tir_receptor_C PF07489.11 ETO21694.1 - 0.56 10.1 5.3 1.6 8.6 5.3 1.7 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus DUF724 PF05266.14 ETO21694.1 - 0.72 9.7 26.5 1.5 8.6 4.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF724) P4Ha_N PF08336.11 ETO21694.1 - 4 7.4 17.0 1 9.4 5.5 2.7 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FAM176 PF14851.6 ETO21695.1 - 1.7 8.3 9.6 0.15 11.7 0.7 2.6 3 0 0 3 3 3 0 FAM176 family Nop52 PF05997.12 ETO21696.1 - 0.44 10.3 8.4 4.1 7.1 0.3 3.1 3 0 0 3 3 3 0 Nucleolar protein,Nop52 Pinin_SDK_N PF04697.13 ETO21699.1 - 0.0084 16.8 1.2 0.013 16.2 1.2 1.2 1 0 0 1 1 1 1 pinin/SDK conserved region fn3 PF00041.21 ETO21700.1 - 0.086 13.2 0.1 2.5 8.5 0.0 2.7 3 0 0 3 3 3 0 Fibronectin type III domain Bac_DnaA PF00308.18 ETO21701.1 - 0.099 12.5 0.1 0.19 11.5 0.1 1.4 1 0 0 1 1 1 0 Bacterial dnaA protein HMD PF03201.16 ETO21703.1 - 1 9.6 9.9 1.2 9.4 2.8 2.7 2 0 0 2 2 2 0 H2-forming N5,N10-methylene-tetrahydromethanopterin dehydrogenase GlcNAc PF11397.8 ETO21704.1 - 2.4e-34 119.4 0.0 2.8e-21 76.4 0.0 2.1 1 1 1 2 2 2 2 Glycosyltransferase (GlcNAc) Polo_box_3 PF18544.1 ETO21706.1 - 0.062 13.9 0.3 0.071 13.8 0.3 1.1 1 0 0 1 1 1 0 Polo box domain Chromo PF00385.24 ETO21707.1 - 1.8e-12 47.0 1.9 7.7e-12 44.9 1.9 2.2 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain Utp14 PF04615.13 ETO21707.1 - 0.00052 18.7 41.6 0.00063 18.5 41.6 1.0 1 0 0 1 1 1 1 Utp14 protein Mitofilin PF09731.9 ETO21707.1 - 0.044 12.6 42.4 0.055 12.3 42.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Macoilin PF09726.9 ETO21707.1 - 0.77 8.2 37.8 1.2 7.6 37.8 1.3 1 0 0 1 1 1 0 Macoilin family Pex14_N PF04695.13 ETO21707.1 - 1.9 9.2 22.0 0.22 12.2 13.6 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4746 PF15928.5 ETO21707.1 - 9.4 5.6 42.2 0.8 9.1 32.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DinB PF05163.12 ETO21710.1 - 0.091 12.7 0.0 0.18 11.7 0.0 1.7 2 0 0 2 2 2 0 DinB family Vps35 PF03635.17 ETO21712.1 - 3.6e-71 240.7 5.2 5.3e-71 240.1 5.2 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 RR_TM4-6 PF06459.12 ETO21712.1 - 0.096 12.5 8.9 0.17 11.7 8.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AXE1 PF05448.12 ETO21712.1 - 0.11 11.2 0.9 0.2 10.3 0.1 1.7 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF2663 PF10864.8 ETO21712.1 - 0.27 11.6 0.1 0.27 11.6 0.1 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF2663) Cwf_Cwc_15 PF04889.12 ETO21712.1 - 0.35 10.6 17.7 0.66 9.7 17.7 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Zip PF02535.22 ETO21712.1 - 0.48 9.6 3.3 0.67 9.1 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO21712.1 - 0.78 8.0 7.6 1 7.6 7.6 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO21712.1 - 1.1 8.0 10.2 1.7 7.3 10.2 1.2 1 0 0 1 1 1 0 Presenilin TFIIF_alpha PF05793.12 ETO21712.1 - 1.3 7.5 22.3 2.4 6.6 22.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 ETO21712.1 - 5.2 5.2 13.8 8.9 4.5 13.8 1.3 1 0 0 1 1 1 0 CDC45-like protein FAD_binding_1 PF00667.20 ETO21714.1 - 1.2e-35 123.1 0.1 1.2e-35 123.1 0.1 2.0 2 0 0 2 2 2 1 FAD binding domain Flavodoxin_1 PF00258.25 ETO21714.1 - 1e-14 55.0 0.0 2.2e-14 53.9 0.0 1.6 1 0 0 1 1 1 1 Flavodoxin DUF3439 PF11921.8 ETO21714.1 - 0.13 12.3 7.8 0.3 11.1 7.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO21714.1 - 0.15 10.0 4.4 0.22 9.5 4.4 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 ETO21714.1 - 0.52 8.5 6.6 0.75 7.9 6.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 NAD_binding_1 PF00175.21 ETO21715.1 - 5.1e-10 40.0 0.1 0.00011 22.8 0.0 2.3 2 0 0 2 2 2 2 Oxidoreductase NAD-binding domain Gal-3-0_sulfotr PF06990.11 ETO21715.1 - 0.015 14.2 0.2 0.02 13.8 0.2 1.1 1 0 0 1 1 1 0 Galactose-3-O-sulfotransferase Ank_5 PF13857.6 ETO21716.1 - 2.1e-07 31.1 0.1 0.0018 18.6 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO21716.1 - 3.5e-07 30.7 0.0 0.00024 21.6 0.0 2.9 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO21716.1 - 4.1e-05 23.6 1.5 0.89 10.3 0.0 4.5 4 1 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO21716.1 - 0.00046 20.7 0.3 0.36 11.5 0.2 2.9 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO21716.1 - 0.00073 19.9 1.8 0.21 12.1 0.0 3.5 3 1 0 3 3 3 1 Ankyrin repeat PI3K_rbd PF00794.18 ETO21717.1 - 7.7e-11 42.1 0.0 7.7e-11 42.1 0.0 2.2 3 0 0 3 3 3 1 PI3-kinase family, ras-binding domain HBB PF06777.11 ETO21717.1 - 0.034 13.8 0.1 0.052 13.2 0.1 1.4 1 0 0 1 1 1 0 Helical and beta-bridge domain SNARE PF05739.19 ETO21717.1 - 0.043 13.8 0.8 0.043 13.8 0.8 2.1 3 0 0 3 3 3 0 SNARE domain LAP1C PF05609.12 ETO21717.1 - 0.045 12.8 2.9 0.054 12.6 2.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Plant_vir_prot PF01307.17 ETO21717.1 - 0.14 12.4 0.6 0.35 11.1 0.2 1.9 2 0 0 2 2 2 0 Plant viral movement protein RIFIN PF02009.16 ETO21717.1 - 0.24 11.2 7.2 0.31 10.9 6.6 1.4 1 1 0 1 1 1 0 Rifin PI3Ka PF00613.20 ETO21718.1 - 6.5e-44 149.5 0.6 1.1e-43 148.8 0.6 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETO21718.1 - 6.5e-42 144.1 0.1 2.6e-31 109.3 0.0 2.5 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ETO21718.1 - 8.2e-13 48.5 0.0 8.2e-13 48.5 0.0 1.8 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 Med13_C PF06333.12 ETO21718.1 - 0.18 11.1 2.7 0.28 10.4 2.7 1.2 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Macoilin PF09726.9 ETO21718.1 - 0.55 8.7 10.2 0.8 8.2 10.2 1.2 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO21718.1 - 1.1 7.9 11.1 1.7 7.4 11.1 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO21718.1 - 2.1 6.5 10.2 3.1 5.9 10.2 1.2 1 0 0 1 1 1 0 Nop14-like family PNISR PF15996.5 ETO21718.1 - 2.8 8.2 6.2 4.2 7.6 6.2 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SLC12 PF03522.15 ETO21718.1 - 8.2 5.3 12.3 13 4.6 12.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TPR_12 PF13424.6 ETO21719.1 - 1.4e-48 163.1 26.5 5.2e-19 68.3 2.3 4.8 2 2 2 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO21719.1 - 4.8e-37 124.8 10.5 1.3e-06 28.1 0.1 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO21719.1 - 1.1e-32 110.5 53.7 1e-08 34.6 2.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21719.1 - 2.7e-28 95.7 44.3 2.8e-07 30.1 1.6 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO21719.1 - 4.5e-27 92.1 17.2 0.0001 22.0 0.1 6.6 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21719.1 - 9.6e-20 69.1 44.1 2.8e-07 30.2 1.3 7.1 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO21719.1 - 1.7e-16 59.5 5.8 0.016 16.0 0.0 7.2 7 1 1 8 8 7 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO21719.1 - 4.6e-12 46.4 3.2 0.0035 18.0 0.4 4.0 4 1 0 4 4 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO21719.1 - 7.4e-10 38.5 20.6 0.006 16.9 0.2 6.2 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO21719.1 - 2.8e-09 36.8 0.9 6.7e-09 35.6 0.2 1.8 1 1 0 1 1 1 1 MalT-like TPR region TPR_6 PF13174.6 ETO21719.1 - 1.1e-07 32.0 23.9 0.0069 17.0 0.5 6.1 6 0 0 6 6 5 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO21719.1 - 1.2e-07 31.0 4.2 0.56 9.7 0.0 5.5 5 0 0 5 5 5 2 SHNi-TPR TPR_19 PF14559.6 ETO21719.1 - 9.9e-07 29.2 14.7 0.023 15.2 0.1 4.5 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO21719.1 - 3.6e-06 26.5 51.3 0.0088 15.7 2.8 8.7 6 3 4 10 10 10 4 TPR repeat TPR_3 PF07720.12 ETO21719.1 - 2.9e-05 23.9 2.6 2.9e-05 23.9 2.6 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO21719.1 - 0.00087 19.5 31.4 0.42 10.9 3.6 5.8 1 1 4 6 6 6 4 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 ETO21719.1 - 0.0011 18.7 20.5 0.03 14.0 0.9 3.3 1 1 1 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO21719.1 - 0.0026 17.8 29.6 1.1 9.4 2.6 6.7 6 1 1 7 7 7 2 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO21719.1 - 0.075 12.8 25.0 6.4 6.6 0.1 5.5 3 1 2 5 5 5 0 Domain of unknown function (DUF5113) NRBF2_MIT PF17169.4 ETO21719.1 - 0.39 11.0 2.3 3.8 7.8 0.2 3.5 3 1 1 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 SPO22 PF08631.10 ETO21719.1 - 2.6 7.5 14.0 2 7.8 0.5 3.8 2 2 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like Vps39_1 PF10366.9 ETO21719.1 - 2.9 8.2 7.0 3.6 7.9 0.1 3.8 2 2 1 3 3 3 0 Vacuolar sorting protein 39 domain 1 Choline_kinase PF01633.20 ETO21721.1 - 5.8e-39 133.9 13.2 1.9e-38 132.2 13.2 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase APH PF01636.23 ETO21721.1 - 0.00053 20.0 0.2 0.0014 18.6 0.1 1.9 2 1 0 2 2 2 1 Phosphotransferase enzyme family Pkinase PF00069.25 ETO21721.1 - 0.0099 15.3 0.7 0.023 14.1 0.7 1.6 1 0 0 1 1 1 1 Protein kinase domain zf-C2H2 PF00096.26 ETO21723.1 - 1.7e-17 62.8 43.4 4.8e-05 23.6 2.6 5.6 5 0 0 5 5 5 5 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO21723.1 - 7e-11 42.0 34.6 0.00087 19.9 1.2 5.5 5 0 0 5 5 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO21723.1 - 1.4e-10 41.1 5.9 9.5e-06 25.8 0.1 5.9 5 1 1 6 6 6 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ETO21723.1 - 5.3e-08 32.9 33.4 0.0044 17.3 0.3 5.7 5 0 0 5 5 5 4 Zinc-finger double-stranded RNA-binding zf_UBZ PF18439.1 ETO21723.1 - 8.5e-05 22.1 15.7 0.21 11.2 0.2 5.3 5 0 0 5 5 5 2 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 ETO21723.1 - 0.00058 19.8 8.8 0.0074 16.3 1.6 5.1 4 1 0 4 4 4 2 C2H2-type zinc finger zf-met PF12874.7 ETO21723.1 - 0.0017 18.7 28.7 0.2 12.1 0.3 5.6 5 0 0 5 5 5 3 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 ETO21723.1 - 0.023 14.8 20.2 1.5 9.0 1.1 4.7 4 1 0 4 4 4 0 Zinc ribbon domain zf-LYAR PF08790.11 ETO21723.1 - 0.072 13.0 2.1 0.072 13.0 2.1 5.4 5 0 0 5 5 5 0 LYAR-type C2HC zinc finger PyrI_C PF02748.15 ETO21723.1 - 0.17 11.8 0.2 0.17 11.8 0.2 4.2 4 0 0 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-BED PF02892.15 ETO21723.1 - 0.21 11.6 21.8 6.3 6.9 0.8 4.5 2 1 2 4 4 4 0 BED zinc finger zf-C2H2_8 PF15909.5 ETO21723.1 - 0.32 11.3 22.9 0.25 11.7 8.8 3.1 1 1 2 3 3 3 0 C2H2-type zinc ribbon C1_4 PF07975.12 ETO21723.1 - 1.9 8.8 32.6 0.85 9.9 6.4 4.4 1 1 3 4 4 4 0 TFIIH C1-like domain zinc_ribbon_15 PF17032.5 ETO21723.1 - 3.9 8.3 30.8 0.54 11.0 4.2 3.2 1 1 2 3 3 3 0 zinc-ribbon family zf-C2H2_2 PF12756.7 ETO21723.1 - 6.3 7.2 35.2 3.3 8.1 3.0 4.6 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-MYST PF17772.1 ETO21723.1 - 7.9 6.2 23.9 0.21 11.2 2.1 3.9 3 1 1 4 4 4 0 MYST family zinc finger domain RRM_1 PF00076.22 ETO21724.1 - 5.1e-13 48.6 0.1 1.5e-12 47.1 0.0 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO21725.1 - 2.6e-05 23.9 0.0 9.6e-05 22.1 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Mito_carr PF00153.27 ETO21726.1 - 0.0019 18.1 0.0 0.0044 16.9 0.0 1.7 1 1 1 2 2 2 1 Mitochondrial carrier protein RHD_DNA_bind PF00554.22 ETO21726.1 - 0.12 12.4 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Rel homology DNA-binding domain MEA1 PF06910.11 ETO21727.1 - 6.5e-10 39.7 1.0 1.1e-09 39.0 1.0 1.5 1 0 0 1 1 1 1 Male enhanced antigen 1 (MEA1) Ezh2_MCSS PF18600.1 ETO21727.1 - 0.043 13.5 1.0 0.12 12.0 0.2 2.0 2 0 0 2 2 2 0 MCSS domain FeoB_C PF07664.12 ETO21728.1 - 0.26 11.0 2.7 8.7 6.1 0.1 2.5 2 0 0 2 2 2 0 Ferrous iron transport protein B C terminus ARPC4 PF05856.12 ETO21729.1 - 6.2e-73 243.9 4.4 7e-73 243.7 4.4 1.0 1 0 0 1 1 1 1 ARP2/3 complex 20 kDa subunit (ARPC4) Anticodon_1 PF08264.13 ETO21730.1 - 0.028 14.4 0.2 0.089 12.8 0.2 1.8 1 0 0 1 1 1 0 Anticodon-binding domain of tRNA PLN_propep PF16485.5 ETO21730.1 - 0.12 12.2 0.1 0.32 10.7 0.1 1.7 1 0 0 1 1 1 0 Protealysin propeptide DUF365 PF04033.12 ETO21730.1 - 0.12 12.6 0.1 0.35 11.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF365) Bromodomain PF00439.25 ETO21732.1 - 1.9e-18 66.3 1.2 3e-18 65.6 0.4 1.8 2 0 0 2 2 2 1 Bromodomain BET PF17035.5 ETO21732.1 - 1.2e-08 34.9 1.2 3.4e-08 33.5 1.2 1.8 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation CDC45 PF02724.14 ETO21732.1 - 0.63 8.3 26.6 0.052 11.9 15.2 2.2 2 0 0 2 2 2 0 CDC45-like protein SDA1 PF05285.12 ETO21732.1 - 7.4 5.9 34.6 1.1 8.6 22.0 2.2 2 0 0 2 2 2 0 SDA1 Nucleo_P87 PF07267.11 ETO21733.1 - 0.093 11.6 4.9 0.1 11.4 4.9 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF4746 PF15928.5 ETO21733.1 - 0.52 9.7 8.9 0.62 9.4 8.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Sec62 PF03839.16 ETO21733.1 - 3.1 7.2 10.2 3.7 7.0 10.2 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Stevor PF17410.2 ETO21733.1 - 3.2 7.2 8.8 3.7 7.0 8.8 1.1 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame TP53IP5 PF15331.6 ETO21733.1 - 3.5 7.7 8.7 4.7 7.3 8.7 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4551 PF15087.6 ETO21733.1 - 4.5 6.0 8.0 5 5.8 8.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RR_TM4-6 PF06459.12 ETO21733.1 - 5.8 6.7 14.6 6.6 6.5 14.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 ETO21733.1 - 6.2 5.5 13.8 7.2 5.3 13.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO21733.1 - 7.8 5.6 10.7 8.3 5.5 10.7 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 ETO21733.1 - 8 5.3 8.1 9.2 5.1 8.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF908 PF06012.12 ETO21733.1 - 8.7 5.6 9.1 10 5.4 9.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Pkinase PF00069.25 ETO21734.1 - 6.2e-18 65.1 9.7 1e-14 54.6 0.2 3.5 3 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21734.1 - 4.7e-06 26.1 0.9 0.061 12.6 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO21734.1 - 0.00045 19.1 0.5 0.0014 17.4 0.0 1.8 2 0 0 2 2 2 1 Fungal protein kinase IPK PF03770.16 ETO21734.1 - 0.026 14.4 0.0 0.026 14.4 0.0 1.8 2 0 0 2 2 2 0 Inositol polyphosphate kinase DUF4834 PF16118.5 ETO21734.1 - 0.065 14.2 8.4 0.86 10.6 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PIP5K PF01504.18 ETO21734.1 - 0.079 12.2 2.7 1.5 8.0 0.0 2.1 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase TRM13 PF05206.14 ETO21734.1 - 0.48 9.9 9.6 0.053 13.0 1.2 2.2 2 0 0 2 2 2 0 Methyltransferase TRM13 FAM176 PF14851.6 ETO21734.1 - 1.1 9.0 11.5 4.2 7.0 0.6 2.3 2 0 0 2 2 2 0 FAM176 family POX PF07526.11 ETO21734.1 - 1.4 9.5 8.8 7.5 7.1 1.0 2.2 2 0 0 2 2 2 0 Associated with HOX DDRGK PF09756.9 ETO21734.1 - 1.9 8.0 22.4 0.63 9.6 10.7 2.1 2 0 0 2 2 2 0 DDRGK domain DUF4366 PF14283.6 ETO21734.1 - 2.3 8.3 8.9 3.1 7.8 1.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) CPSF100_C PF13299.6 ETO21734.1 - 4.3 7.5 7.6 12 6.1 0.7 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Nop14 PF04147.12 ETO21736.1 - 0.017 13.4 1.6 0.021 13.1 1.6 1.0 1 0 0 1 1 1 0 Nop14-like family YqzM PF14141.6 ETO21736.1 - 0.018 15.1 2.0 0.018 15.1 2.0 2.2 3 0 0 3 3 3 0 YqzM-like protein CemA PF03040.14 ETO21736.1 - 0.054 13.4 3.5 0.067 13.1 3.5 1.1 1 0 0 1 1 1 0 CemA family LOB PF03195.14 ETO21736.1 - 0.062 13.9 0.5 0.062 13.9 0.5 1.9 2 0 0 2 2 2 0 Lateral organ boundaries (LOB) domain DUF819 PF05684.12 ETO21736.1 - 0.11 11.5 0.2 0.12 11.3 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF819) DUF2207 PF09972.9 ETO21736.1 - 0.12 11.1 1.1 0.13 11.0 1.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Connexin PF00029.19 ETO21738.1 - 0.021 14.6 0.8 0.026 14.3 0.8 1.1 1 0 0 1 1 1 0 Connexin UMPH-1 PF05822.12 ETO21739.1 - 4.9e-15 55.7 1.1 9.1e-15 54.8 1.1 1.4 1 1 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) HAD PF12710.7 ETO21739.1 - 1.1e-05 25.9 0.0 2e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Nore1-SARAH PF16517.5 ETO21739.1 - 0.048 13.6 4.8 0.13 12.2 4.8 1.8 1 0 0 1 1 1 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain UMPH-1 PF05822.12 ETO21740.1 - 1.8e-14 53.9 0.1 2.1e-14 53.6 0.1 1.1 1 0 0 1 1 1 1 Pyrimidine 5'-nucleotidase (UMPH-1) LPD1 PF18796.1 ETO21740.1 - 0.13 12.4 0.0 0.23 11.6 0.0 1.6 1 1 0 1 1 1 0 Large polyvalent protein-associated domain 1 DUF460 PF04312.13 ETO21741.1 - 0.0064 16.2 0.6 2.6 7.7 0.1 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF460) O-ag_pol_Wzy PF14296.6 ETO21741.1 - 0.013 14.2 1.8 0.013 14.2 1.8 1.4 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy Usp PF00582.26 ETO21741.1 - 0.025 15.1 0.0 0.053 14.0 0.0 1.5 1 0 0 1 1 1 0 Universal stress protein family Aldedh PF00171.22 ETO21742.1 - 1.7e-05 23.5 0.2 2e-05 23.3 0.2 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4160 PF13711.6 ETO21742.1 - 0.026 14.8 0.4 0.067 13.5 0.3 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4160) SH2_2 PF14633.6 ETO21742.1 - 0.048 13.1 3.1 0.043 13.2 2.2 1.4 1 1 1 2 2 2 0 SH2 domain DisA-linker PF10635.9 ETO21742.1 - 0.053 13.3 0.1 0.072 12.9 0.1 1.2 1 0 0 1 1 1 0 DisA bacterial checkpoint controller linker region Lant_dehydr_C PF14028.6 ETO21742.1 - 0.069 12.7 0.8 0.084 12.4 0.8 1.1 1 0 0 1 1 1 0 Lantibiotic biosynthesis dehydratase C-term DUF5568 PF17724.1 ETO21742.1 - 0.09 12.6 0.5 0.13 12.0 0.5 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5568) RAC_head PF16717.5 ETO21742.1 - 0.1 13.5 6.7 0.2 12.7 6.7 1.5 1 1 0 1 1 1 0 Ribosome-associated complex head domain Efg1 PF10153.9 ETO21742.1 - 0.25 11.7 6.5 0.61 10.5 6.5 1.6 1 1 0 1 1 1 0 rRNA-processing protein Efg1 WD40 PF00400.32 ETO21743.1 - 3.7e-06 27.6 1.5 5.3 8.1 0.0 5.1 5 0 0 5 5 5 3 WD domain, G-beta repeat Inhibitor_I71 PF12628.7 ETO21743.1 - 2.9 7.7 12.2 0.2 11.5 5.4 2.4 2 1 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor Presenilin PF01080.17 ETO21743.1 - 8.8 5.0 7.3 14 4.3 7.3 1.2 1 0 0 1 1 1 0 Presenilin MSP1_C PF07462.11 ETO21744.1 - 0.0044 15.8 0.6 0.0056 15.4 0.6 1.1 1 0 0 1 1 1 1 Merozoite surface protein 1 (MSP1) C-terminus FliD_N PF02465.18 ETO21744.1 - 0.065 13.9 8.8 0.14 12.9 8.8 1.5 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus rRNA_processing PF08524.11 ETO21745.1 - 0.018 15.1 7.6 0.023 14.7 7.6 1.0 1 0 0 1 1 1 0 rRNA processing Hydin_ADK PF17213.3 ETO21745.1 - 0.035 14.4 0.5 0.043 14.1 0.5 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Menin PF05053.13 ETO21745.1 - 3 6.1 12.7 3.5 5.9 12.7 1.1 1 0 0 1 1 1 0 Menin DUF3537 PF12056.8 ETO21745.1 - 3.2 6.5 4.8 3.8 6.2 4.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) CSG2 PF16965.5 ETO21745.1 - 4.2 6.2 6.8 3.9 6.3 6.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 ETO21745.1 - 4.8 5.8 10.4 5.3 5.7 10.4 1.0 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO21745.1 - 7.6 5.2 10.2 8.6 5.1 10.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter SLBB PF10531.9 ETO21746.1 - 0.048 13.5 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 SLBB domain Presenilin PF01080.17 ETO21747.1 - 3.4 6.3 7.6 3.3 6.4 7.6 1.0 1 0 0 1 1 1 0 Presenilin ANAPC4_WD40 PF12894.7 ETO21749.1 - 8.6e-05 22.8 0.1 0.11 12.8 0.0 3.5 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Coatomer_WDAD PF04053.14 ETO21749.1 - 0.0055 15.8 0.4 0.99 8.4 0.0 3.0 1 1 2 3 3 3 2 Coatomer WD associated region PQQ_2 PF13360.6 ETO21749.1 - 0.046 13.3 0.0 0.1 12.2 0.0 1.5 1 1 0 1 1 1 0 PQQ-like domain Cytochrom_D1 PF02239.16 ETO21749.1 - 0.13 10.8 0.0 0.15 10.6 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain CUE PF02845.16 ETO21750.1 - 0.0013 18.3 0.3 0.0034 17.1 0.3 1.7 1 0 0 1 1 1 1 CUE domain UBA_4 PF14555.6 ETO21750.1 - 0.038 13.8 0.1 0.07 13.0 0.1 1.4 1 0 0 1 1 1 0 UBA-like domain NPCC PF08058.11 ETO21751.1 - 0.028 14.5 1.8 0.072 13.1 1.8 1.8 1 1 0 1 1 1 0 Nuclear pore complex component CBS PF00571.28 ETO21752.1 - 2.2e-05 24.8 0.0 4.4e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 CBS domain ZT_dimer PF16916.5 ETO21752.1 - 0.044 13.9 0.1 0.59 10.3 0.0 2.3 2 0 0 2 2 2 0 Dimerisation domain of Zinc Transporter WD40 PF00400.32 ETO21753.1 - 4.4e-50 166.6 32.2 2.8e-09 37.5 0.7 7.2 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21753.1 - 2.2e-18 66.3 3.1 0.00065 19.9 0.2 5.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21753.1 - 3.6e-11 42.6 0.1 0.0044 16.0 0.0 5.4 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO21753.1 - 1.3e-07 31.7 0.2 0.02 14.8 0.1 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO21753.1 - 6.4e-05 21.8 8.8 0.72 8.4 0.1 4.9 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO21753.1 - 8.6e-05 22.0 0.2 0.07 12.5 0.0 3.2 2 2 2 4 4 4 3 WD40-like domain Me-amine-dh_H PF06433.11 ETO21753.1 - 0.0069 15.3 0.0 0.021 13.7 0.0 1.8 2 0 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO21753.1 - 0.0089 15.9 3.9 2.8 8.0 0.3 4.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Ricin_B_lectin PF00652.22 ETO21753.1 - 0.024 14.9 1.4 0.77 10.0 0.2 2.9 1 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain Ribosomal_L7Ae PF01248.26 ETO21753.1 - 0.09 12.5 0.0 12 5.7 0.0 3.3 3 0 0 3 3 3 0 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family YafQ_toxin PF15738.5 ETO21753.1 - 0.13 12.6 0.1 0.13 12.6 0.1 2.1 2 0 0 2 2 2 0 Bacterial toxin of type II toxin-antitoxin system, YafQ PALB2_WD40 PF16756.5 ETO21753.1 - 0.18 10.7 4.9 7.3 5.4 0.0 3.6 3 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Syntaxin_2 PF14523.6 ETO21754.1 - 3.1e-22 78.9 9.7 3.9e-22 78.5 9.7 1.1 1 0 0 1 1 1 1 Syntaxin-like protein WD40 PF00400.32 ETO21756.1 - 5.5e-53 175.8 25.2 9.6e-10 38.9 0.2 8.0 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21756.1 - 9.5e-19 67.5 3.4 0.00039 20.7 0.1 6.8 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21756.1 - 9.1e-11 41.3 1.1 0.051 12.5 0.0 5.6 1 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO21756.1 - 2.9e-06 26.8 23.3 0.00029 20.3 0.8 5.2 4 2 1 5 5 5 3 WD40-like domain Kelch_1 PF01344.25 ETO21756.1 - 3.3e-05 23.4 0.9 2.9 7.5 0.0 3.8 3 0 0 3 3 3 3 Kelch motif Nup160 PF11715.8 ETO21756.1 - 0.00012 20.8 5.5 2.4 6.7 0.1 5.0 2 1 1 5 5 5 3 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO21756.1 - 0.00043 20.5 8.4 1 9.7 0.0 5.2 4 1 1 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO21756.1 - 0.015 15.3 1.0 25 5.0 1.6 4.0 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO21756.1 - 0.015 15.6 1.3 0.29 11.5 0.0 3.1 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO21756.1 - 0.018 15.1 0.2 0.29 11.2 0.1 3.2 2 0 0 2 2 2 0 Galactose oxidase, central domain PQQ PF01011.21 ETO21756.1 - 0.13 12.2 0.0 27 4.9 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat PD40 PF07676.12 ETO21756.1 - 0.15 12.0 0.6 14 5.8 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Multi_Drug_Res PF00893.19 ETO21757.1 - 0.094 13.4 0.3 0.25 12.0 0.1 1.7 2 0 0 2 2 2 0 Small Multidrug Resistance protein CDC45 PF02724.14 ETO21759.1 - 0.075 11.3 5.6 0.1 10.9 5.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF755 PF05501.11 ETO21759.1 - 1.9 8.8 10.4 3.5 7.9 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF378 PF04070.12 ETO21759.1 - 2.2 8.2 10.5 5.8 6.9 0.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF378) SBP_bac_11 PF13531.6 ETO21761.1 - 3.6e-05 23.6 0.0 6e-05 22.9 0.0 1.4 1 1 0 1 1 1 1 Bacterial extracellular solute-binding protein WD40 PF00400.32 ETO21762.1 - 9.7e-06 26.2 2.0 2.7e-05 24.8 0.4 2.5 3 1 0 3 3 3 1 WD domain, G-beta repeat Utp14 PF04615.13 ETO21763.1 - 1.9 7.0 33.1 3 6.3 33.1 1.2 1 0 0 1 1 1 0 Utp14 protein RRM_1 PF00076.22 ETO21764.1 - 4.1e-07 29.7 0.0 7.7e-07 28.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PNISR PF15996.5 ETO21765.1 - 3 8.1 21.6 2.8 8.2 3.9 2.2 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR FlgH PF02107.16 ETO21765.1 - 6.8 6.3 17.4 0.13 11.8 5.6 2.4 2 0 0 2 2 2 0 Flagellar L-ring protein COX6C PF02937.15 ETO21767.1 - 8.6 6.6 9.5 1.3 9.2 0.6 3.3 3 0 0 3 3 3 0 Cytochrome c oxidase subunit VIc PHD PF00628.29 ETO21770.1 - 5.7e-08 32.5 5.5 5.7e-08 32.5 5.5 4.2 4 0 0 4 4 4 1 PHD-finger zf-C3HC4_2 PF13923.6 ETO21770.1 - 9.3e-05 22.2 0.6 9.3e-05 22.2 0.6 3.1 3 1 0 3 3 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO21770.1 - 0.00015 22.0 1.2 0.00015 22.0 1.2 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4 PF00097.25 ETO21770.1 - 0.00048 19.9 1.2 0.00048 19.9 1.2 3.4 3 1 1 4 4 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO21770.1 - 0.0016 18.7 0.9 0.0016 18.7 0.9 3.7 3 0 0 3 3 3 1 RING-H2 zinc finger domain PHD_2 PF13831.6 ETO21770.1 - 0.0043 16.6 6.6 0.011 15.3 2.0 2.8 2 0 0 2 2 2 1 PHD-finger zf-C3HC4_4 PF15227.6 ETO21770.1 - 0.0076 16.4 6.5 0.071 13.3 0.4 3.3 3 0 0 3 3 3 1 zinc finger of C3HC4-type, RING DUF2244 PF10003.9 ETO21770.1 - 0.05 13.3 0.1 0.094 12.4 0.1 1.3 1 0 0 1 1 1 0 Integral membrane protein (DUF2244) zf-ANAPC11 PF12861.7 ETO21770.1 - 0.052 13.6 0.2 0.052 13.6 0.2 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger DUF4186 PF13811.6 ETO21770.1 - 1.3 9.1 4.5 3.5 7.7 0.1 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4186) C1_2 PF03107.16 ETO21770.1 - 9.9 6.6 14.1 0.3 11.4 0.8 3.3 3 0 0 3 3 3 0 C1 domain SIX1_SD PF16878.5 ETO21771.1 - 0.79 10.3 0.1 0.79 10.3 0.1 3.0 4 1 1 5 5 5 0 Transcriptional regulator, SIX1, N-terminal SD domain Peptidase_U57 PF05582.12 ETO21771.1 - 2.3 7.4 8.0 0.074 12.3 1.0 2.0 2 0 0 2 2 2 0 YabG peptidase U57 Myosin_TH1 PF06017.13 ETO21772.1 - 0.011 15.4 11.3 0.041 13.6 11.3 2.0 1 1 0 1 1 1 0 Unconventional myosin tail, actin- and lipid-binding Gal11_ABD1 PF18535.1 ETO21772.1 - 0.019 15.1 0.0 0.046 13.8 0.0 1.6 1 0 0 1 1 1 0 Gal11 activator-binding domain (ABD1) C2 PF00168.30 ETO21773.1 - 1.3e-09 38.3 0.1 2.2e-09 37.5 0.1 1.4 1 0 0 1 1 1 1 C2 domain Nop14 PF04147.12 ETO21773.1 - 0.0043 15.4 7.4 0.0047 15.2 7.4 1.2 1 0 0 1 1 1 1 Nop14-like family TRAP_alpha PF03896.16 ETO21773.1 - 0.0062 15.8 4.5 0.0096 15.2 4.5 1.3 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit BUD22 PF09073.10 ETO21773.1 - 0.012 15.0 9.9 0.018 14.4 9.9 1.3 1 0 0 1 1 1 0 BUD22 DUF4746 PF15928.5 ETO21773.1 - 0.012 15.0 4.9 0.02 14.3 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF913 PF06025.12 ETO21773.1 - 0.03 13.3 2.8 0.042 12.8 2.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO21773.1 - 0.049 12.9 2.1 0.057 12.6 2.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO21773.1 - 0.2 10.4 4.0 0.22 10.2 4.0 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO21773.1 - 0.22 9.8 7.6 0.27 9.5 7.6 1.2 1 0 0 1 1 1 0 CDC45-like protein CSG2 PF16965.5 ETO21773.1 - 0.31 10.0 1.6 0.45 9.4 1.6 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 ETO21773.1 - 0.34 9.9 0.7 0.48 9.4 0.7 1.3 1 0 0 1 1 1 0 CLN3 protein DUF4820 PF16091.5 ETO21773.1 - 0.35 10.2 4.6 0.72 9.2 4.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) FmiP_Thoc5 PF09766.9 ETO21773.1 - 0.41 9.9 11.9 0.41 9.9 10.7 1.4 1 1 0 1 1 1 0 Fms-interacting protein/Thoc5 DUF1980 PF09323.10 ETO21773.1 - 0.43 10.5 3.0 0.23 11.3 0.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Stn1 PF10451.9 ETO21773.1 - 0.9 8.4 5.5 0.35 9.8 2.9 1.6 2 0 0 2 2 2 0 Telomere regulation protein Stn1 DUF5308 PF17233.2 ETO21773.1 - 1.7 8.8 10.0 3.5 7.8 10.0 1.6 1 1 0 1 1 1 0 Family of unknown function (DUF5308) Pox_Ag35 PF03286.14 ETO21773.1 - 2.7 7.7 17.8 2.1 8.1 13.7 2.1 1 1 1 2 2 2 0 Pox virus Ag35 surface protein DUF4637 PF15470.6 ETO21773.1 - 4.8 6.9 11.1 9 6.0 11.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3439 PF11921.8 ETO21774.1 - 0.14 12.1 6.5 0.26 11.3 6.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CDC45 PF02724.14 ETO21774.1 - 0.18 10.0 8.7 0.22 9.8 8.7 1.2 1 0 0 1 1 1 0 CDC45-like protein SSP160 PF06933.11 ETO21774.1 - 1.1 7.4 9.4 1.5 6.9 9.4 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Peptidase_S64 PF08192.11 ETO21774.1 - 1.2 7.6 16.3 1.3 7.4 16.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 Zip PF02535.22 ETO21774.1 - 5.1 6.2 7.9 3.3 6.8 5.4 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter Ac76 PF05814.11 ETO21774.1 - 5.9 7.0 5.9 3.7 7.6 0.1 2.6 2 0 0 2 2 2 0 Orf76 (Ac76) Menin PF05053.13 ETO21774.1 - 8.7 4.6 9.4 15 3.8 9.4 1.4 1 0 0 1 1 1 0 Menin DUF4047 PF13256.6 ETO21775.1 - 0.22 11.7 3.4 0.74 10.0 3.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4047) NHS PF15273.6 ETO21775.1 - 0.26 10.3 4.4 0.34 10.0 4.4 1.1 1 0 0 1 1 1 0 NHS-like DUF4201 PF13870.6 ETO21777.1 - 1.7e-33 115.8 30.5 1.7e-33 115.8 30.5 3.7 3 1 1 4 4 4 1 Domain of unknown function (DUF4201) Adhesin_P1 PF03257.13 ETO21777.1 - 0.005 17.3 2.0 0.011 16.2 1.7 1.7 1 1 0 1 1 1 1 Mycoplasma adhesin P1 CRF PF00473.17 ETO21777.1 - 0.65 10.1 4.4 3.1 7.9 0.7 2.9 2 0 0 2 2 2 0 Corticotropin-releasing factor family RabGAP-TBC PF00566.18 ETO21778.1 - 4.8e-12 46.0 9.2 1.9e-11 44.0 9.2 2.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Ndc1_Nup PF09531.10 ETO21778.1 - 0.00021 20.2 5.8 0.00026 19.8 5.8 1.1 1 0 0 1 1 1 1 Nucleoporin protein Ndc1-Nup Corona_nucleoca PF00937.18 ETO21778.1 - 0.063 12.3 6.0 0.1 11.6 6.0 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein DUF1151 PF06625.11 ETO21778.1 - 6.3 6.8 13.2 1.6 8.7 7.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1151) RabGAP-TBC PF00566.18 ETO21779.1 - 3e-11 43.4 2.4 3e-11 43.4 2.4 2.6 2 0 0 2 2 2 1 Rab-GTPase-TBC domain PH PF00169.29 ETO21779.1 - 0.056 14.0 0.7 0.09 13.3 0.1 1.8 2 0 0 2 2 2 0 PH domain RP-C_C PF11800.8 ETO21779.1 - 0.27 11.3 3.9 0.45 10.6 3.9 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region ALMT PF11744.8 ETO21779.1 - 1 8.1 7.0 1.7 7.4 7.0 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Secretin_N_2 PF07655.13 ETO21779.1 - 8.3 7.0 20.5 17 6.1 20.5 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Kelch_6 PF13964.6 ETO21781.1 - 0.00042 20.5 1.0 0.0032 17.7 0.1 2.5 1 1 1 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO21781.1 - 0.00059 19.4 0.2 0.0015 18.0 0.2 1.7 1 0 0 1 1 1 1 Kelch motif Kelch_4 PF13418.6 ETO21781.1 - 0.013 15.5 0.4 0.03 14.3 0.0 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain DUF1971 PF09313.11 ETO21781.1 - 0.12 12.5 0.0 0.24 11.5 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1971) Kelch_2 PF07646.15 ETO21781.1 - 0.12 12.4 1.2 1.2 9.3 0.2 2.6 2 0 0 2 2 2 0 Kelch motif DUF2457 PF10446.9 ETO21782.1 - 0.43 9.7 16.3 0.48 9.5 16.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO21782.1 - 0.53 8.4 14.1 0.67 8.1 14.1 1.0 1 0 0 1 1 1 0 Nop14-like family ASD2 PF08687.11 ETO21782.1 - 0.54 9.8 8.7 0.7 9.4 8.7 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 PDDEXK_6 PF04720.12 ETO21782.1 - 4.3 7.2 8.0 5.5 6.9 8.0 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function PBP1_TM PF14812.6 ETO21782.1 - 7.5 7.0 11.6 4.8 7.6 9.1 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal ACAS_N PF16177.5 ETO21783.1 - 0.11 12.5 0.3 0.21 11.5 0.3 1.5 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus FtsX PF02687.21 ETO21785.1 - 8.1e-06 26.2 0.3 8.1e-06 26.2 0.3 2.6 2 0 0 2 2 2 1 FtsX-like permease family Kringle PF00051.18 ETO21785.1 - 0.00014 22.1 0.6 0.00038 20.7 0.6 1.8 1 0 0 1 1 1 1 Kringle domain Gal_Lectin PF02140.18 ETO21785.1 - 0.00016 22.0 1.8 0.00035 20.9 1.8 1.6 1 0 0 1 1 1 1 Galactose binding lectin domain HTH_46 PF15977.5 ETO21785.1 - 0.11 12.5 0.0 0.38 10.8 0.0 1.9 1 0 0 1 1 1 0 Winged helix-turn-helix DNA binding SDA1 PF05285.12 ETO21786.1 - 0.00025 20.6 12.6 0.00025 20.6 12.6 2.2 2 0 0 2 2 2 1 SDA1 CDC45 PF02724.14 ETO21786.1 - 0.045 12.1 25.4 0.026 12.8 13.0 2.1 2 0 0 2 2 2 0 CDC45-like protein Presenilin PF01080.17 ETO21786.1 - 0.076 11.8 29.3 0.24 10.1 7.5 2.2 2 0 0 2 2 2 0 Presenilin Nop14 PF04147.12 ETO21786.1 - 0.48 8.6 32.6 0.015 13.6 17.0 2.1 2 0 0 2 2 2 0 Nop14-like family Caldesmon PF02029.15 ETO21786.1 - 0.76 8.5 32.1 0.33 9.6 18.9 2.1 2 0 0 2 2 2 0 Caldesmon Vfa1 PF08432.10 ETO21786.1 - 0.78 10.0 35.0 0.22 11.8 18.8 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 ETO21786.1 - 1.9 8.2 27.1 0.47 10.2 13.7 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ETO21786.1 - 3.2 7.8 24.9 5.9 6.9 24.9 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 SpoIIIAH PF12685.7 ETO21786.1 - 3.9 7.2 36.3 0.11 12.4 9.5 2.3 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF3807 PF12720.7 ETO21786.1 - 4.6 7.5 36.8 4.5 7.5 16.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) DUF5308 PF17233.2 ETO21786.1 - 7.6 6.7 13.6 12 6.1 3.3 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5308) RNA_pol_Rpc4 PF05132.14 ETO21786.1 - 8.1 6.9 23.9 11 6.4 13.6 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 NPR3 PF03666.13 ETO21786.1 - 8.3 5.1 38.9 2.1 7.0 14.3 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Alpha_kinase PF02816.18 ETO21787.1 - 1.6e-54 184.8 0.6 4.1e-54 183.5 0.6 1.6 1 1 0 1 1 1 1 Alpha-kinase family RTBV_P12 PF06361.11 ETO21787.1 - 0.1 13.0 0.0 0.26 11.7 0.0 1.7 1 0 0 1 1 1 0 Rice tungro bacilliform virus P12 protein RRM_1 PF00076.22 ETO21788.1 - 0.025 14.4 0.0 0.72 9.7 0.0 2.4 1 1 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO21789.1 - 3.3e-06 26.8 0.0 1.6e-05 24.6 0.0 2.1 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pkinase PF00069.25 ETO21790.1 - 3.1e-64 216.9 0.0 4.6e-64 216.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21790.1 - 4.5e-28 98.2 0.0 7.4e-28 97.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO21790.1 - 8e-05 21.6 0.0 0.00018 20.4 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO21790.1 - 8.3e-05 22.0 0.1 0.00019 20.9 0.0 1.7 2 0 0 2 2 2 1 Kinase-like Haspin_kinase PF12330.8 ETO21790.1 - 0.0052 15.8 0.1 0.0084 15.1 0.1 1.3 1 0 0 1 1 1 1 Haspin like kinase domain NPR1_interact PF15699.5 ETO21790.1 - 0.49 11.0 3.6 21 5.8 0.0 3.2 3 0 0 3 3 3 0 NPR1 interacting WD40_4 PF16300.5 ETO21791.1 - 1.4e-18 66.5 0.1 2.6e-18 65.6 0.1 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 ETO21791.1 - 1.8e-10 41.2 1.8 1.4e-05 25.8 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21791.1 - 8.6e-06 26.0 0.0 0.0025 18.1 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO21791.1 - 0.0001 21.1 0.0 0.00046 19.0 0.0 1.8 2 0 0 2 2 2 1 Nucleoporin Nup120/160 DivIC PF04977.15 ETO21791.1 - 0.00095 18.9 0.3 0.0017 18.1 0.3 1.4 1 0 0 1 1 1 1 Septum formation initiator ABC_tran_CTD PF16326.5 ETO21791.1 - 0.0056 16.9 3.2 0.0087 16.3 3.2 1.3 1 0 0 1 1 1 1 ABC transporter C-terminal domain GP52 PF17468.2 ETO21791.1 - 0.026 14.6 0.0 0.096 12.9 0.0 1.8 2 0 0 2 2 2 0 Phage gene product 52 bZIP_2 PF07716.15 ETO21791.1 - 0.034 14.2 2.0 0.065 13.3 2.0 1.4 1 0 0 1 1 1 0 Basic region leucine zipper IFP_35_N PF07334.13 ETO21791.1 - 0.042 13.9 0.3 0.091 12.8 0.3 1.5 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus WD40_like PF17005.5 ETO21791.1 - 0.046 13.0 0.0 5.6 6.2 0.0 2.2 2 0 0 2 2 2 0 WD40-like domain DUF1192 PF06698.11 ETO21791.1 - 0.081 13.0 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1192) HR1 PF02185.16 ETO21791.1 - 0.085 13.0 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 Hr1 repeat DUF883 PF05957.13 ETO21792.1 - 2.8 8.6 8.8 20 5.8 0.7 3.5 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) DUF1283 PF06932.11 ETO21792.1 - 4 7.7 9.1 7.3 6.9 0.5 3.6 3 1 1 4 4 4 0 Protein of unknown function (DUF1283) DUF5414 PF17435.2 ETO21794.1 - 0.08 12.6 0.1 0.17 11.5 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5414) RhoGEF PF00621.20 ETO21795.1 - 3e-16 60.2 0.1 6e-16 59.2 0.0 1.5 2 0 0 2 2 2 1 RhoGEF domain Colicin_V PF02674.16 ETO21796.1 - 0.25 11.3 2.3 0.58 10.1 2.3 1.5 1 0 0 1 1 1 0 Colicin V production protein PSA_CBD PF18341.1 ETO21797.1 - 0.00043 20.3 1.1 0.001 19.0 0.0 2.3 2 1 0 2 2 2 1 PSA endolysin C-terminal cell wall binding domain DUF1676 PF07898.13 ETO21797.1 - 0.22 11.5 4.4 0.1 12.6 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) PRIMA1 PF16101.5 ETO21797.1 - 1.4 9.0 3.9 18 5.4 0.3 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 TMEM154 PF15102.6 ETO21797.1 - 2.9 7.8 7.2 1 9.2 3.0 2.1 2 0 0 2 2 2 0 TMEM154 protein family DUF4389 PF14333.6 ETO21797.1 - 4.6 7.2 11.0 0.89 9.5 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4389) URO-D PF01208.17 ETO21799.1 - 1.7e-108 362.9 0.0 1.9e-108 362.7 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen decarboxylase (URO-D) VPS9 PF02204.18 ETO21800.1 - 2.5e-08 34.0 0.7 7.2e-08 32.6 0.1 2.2 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain DUF5074 PF16819.5 ETO21800.1 - 0.0015 18.5 1.2 0.006 16.6 0.9 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF5074) CAP_N PF01213.19 ETO21801.1 - 0.0025 17.3 2.3 0.003 17.1 2.3 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal DUF4136 PF13590.6 ETO21801.1 - 0.036 14.7 0.5 0.04 14.5 0.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4136) LegC3_N PF18654.1 ETO21801.1 - 0.056 12.7 3.4 0.064 12.5 3.4 1.1 1 0 0 1 1 1 0 LegC3 N-terminal coiled-coil domain TEX19 PF15553.6 ETO21801.1 - 0.12 12.4 0.8 0.13 12.2 0.8 1.2 1 0 0 1 1 1 0 Testis-expressed protein 19 AARP2CN PF08142.12 ETO21801.1 - 0.44 10.7 1.7 0.63 10.2 1.7 1.5 1 1 0 1 1 1 0 AARP2CN (NUC121) domain Pex14_N PF04695.13 ETO21801.1 - 0.56 10.8 6.5 0.53 10.9 5.6 1.3 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Caskin-Pro-rich PF16907.5 ETO21801.1 - 0.91 10.1 9.0 1.5 9.4 9.0 1.4 1 1 0 1 1 1 0 Proline rich region of Caskin proteins CDC45 PF02724.14 ETO21801.1 - 7.6 4.7 9.0 7.1 4.8 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 ETO21804.1 - 1.5e-15 57.3 0.0 1.9e-15 56.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21804.1 - 0.0024 17.2 0.0 0.0032 16.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ACP53EA PF06313.11 ETO21804.1 - 0.097 12.9 0.0 1.8 8.8 0.0 2.3 1 1 1 2 2 2 0 Drosophila ACP53EA protein PH PF00169.29 ETO21805.1 - 4.5e-09 36.8 8.5 3.4e-07 30.7 0.1 3.3 3 1 0 3 3 3 2 PH domain CDC45 PF02724.14 ETO21805.1 - 0.0041 15.5 7.2 0.0044 15.4 7.2 1.1 1 0 0 1 1 1 1 CDC45-like protein PH_11 PF15413.6 ETO21805.1 - 0.01 16.2 6.4 0.29 11.6 2.1 2.9 2 1 0 2 2 2 0 Pleckstrin homology domain TFIIF_alpha PF05793.12 ETO21805.1 - 1.1 7.7 20.6 1.5 7.3 20.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Presenilin PF01080.17 ETO21805.1 - 1.4 7.6 5.0 1.8 7.2 5.0 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO21805.1 - 2.4 7.3 4.4 3.1 6.9 4.4 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PNISR PF15996.5 ETO21805.1 - 4.9 7.4 15.9 7.5 6.8 15.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR ELL PF10390.9 ETO21807.1 - 0.00082 19.0 1.5 0.001 18.7 0.4 1.8 2 0 0 2 2 2 1 RNA polymerase II elongation factor ELL Na_trans_assoc PF06512.13 ETO21807.1 - 0.059 13.7 8.6 0.15 12.3 3.0 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated CENP-B_dimeris PF09026.10 ETO21807.1 - 0.55 10.6 4.3 1.4 9.4 4.3 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF4484 PF14831.6 ETO21807.1 - 0.85 9.6 7.8 6.1 6.8 1.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4484) Merozoite_SPAM PF07133.11 ETO21808.1 - 0.0015 18.6 17.7 0.0015 18.6 17.7 3.0 2 1 0 2 2 2 1 Merozoite surface protein (SPAM) ATR13 PF16829.5 ETO21808.1 - 0.09 13.1 0.7 0.28 11.6 0.1 2.0 2 0 0 2 2 2 0 Avirulence protein ATR13, RxLR effector tRNA-synt_1 PF00133.22 ETO21809.1 - 3.8e-18 65.1 1.7 1.8e-15 56.2 0.0 2.1 2 0 0 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETO21809.1 - 0.0035 16.2 0.4 0.0056 15.5 0.1 1.4 1 1 0 1 1 1 1 tRNA synthetases class I (M) Cpn60_TCP1 PF00118.24 ETO21811.1 - 3.9e-162 540.3 7.2 4.4e-162 540.1 7.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Piezo_RRas_bdg PF12166.8 ETO21811.1 - 0.037 13.3 0.1 0.052 12.8 0.1 1.2 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain HEAT PF02985.22 ETO21813.1 - 0.00055 20.0 0.3 0.027 14.7 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat Pro_sub2 PF18513.1 ETO21815.1 - 0.091 12.9 4.8 2 8.7 0.3 2.2 1 1 1 2 2 2 0 Prodomain subtilisin 2 Nop14 PF04147.12 ETO21817.1 - 0.0024 16.2 31.7 0.0024 16.2 31.7 2.1 2 0 0 2 2 2 1 Nop14-like family Caldesmon PF02029.15 ETO21817.1 - 0.0052 15.6 36.8 0.007 15.2 29.0 2.2 2 0 0 2 2 2 2 Caldesmon DUF913 PF06025.12 ETO21817.1 - 0.94 8.4 18.0 3.9 6.4 0.2 2.7 2 1 0 2 2 2 0 Domain of Unknown Function (DUF913) Astro_capsid_p PF12226.8 ETO21817.1 - 1.3 8.2 25.5 2.7 7.1 25.5 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CDC45 PF02724.14 ETO21817.1 - 3.2 5.9 36.2 0.092 11.0 25.6 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF5523 PF17661.1 ETO21817.1 - 3.5 7.2 35.8 0.063 13.0 23.2 2.6 3 0 0 3 3 3 0 Family of unknown function (DUF5523) Sporozoite_P67 PF05642.11 ETO21817.1 - 9.9 4.1 15.3 20 3.1 15.3 1.5 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Npun_R1517 PF18068.1 ETO21818.1 - 0.056 13.8 0.2 0.16 12.3 0.2 1.8 1 0 0 1 1 1 0 Npun R1517 SpecificRecomb PF10136.9 ETO21819.1 - 0.022 13.1 0.0 0.027 12.8 0.0 1.1 1 0 0 1 1 1 0 Site-specific recombinase CDC27 PF09507.10 ETO21819.1 - 0.033 13.6 6.4 0.038 13.4 6.4 1.0 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF1387 PF07139.11 ETO21820.1 - 2.4 7.8 13.1 3 7.5 13.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Nop53 PF07767.11 ETO21821.1 - 0.16 11.3 31.1 0.27 10.6 31.1 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) EF-hand_7 PF13499.6 ETO21821.1 - 0.27 11.7 3.6 5.6 7.5 1.6 3.0 2 1 0 2 2 2 0 EF-hand domain pair PA26 PF04636.13 ETO21821.1 - 6.9 5.5 13.5 12 4.6 13.5 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) CDC45 PF02724.14 ETO21821.1 - 7.8 4.6 26.4 15 3.7 26.4 1.4 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 ETO21821.1 - 9.8 4.6 25.5 12 4.3 25.5 1.2 1 0 0 1 1 1 0 Macoilin family Peptidase_M15_3 PF08291.11 ETO21822.1 - 4.8e-24 84.6 0.1 5.1e-14 52.3 0.0 2.5 2 0 0 2 2 2 2 Peptidase M15 Peptidase_M15_2 PF05951.13 ETO21822.1 - 0.00063 19.4 0.1 0.69 9.6 0.0 2.5 2 0 0 2 2 2 2 Bacterial protein of unknown function (DUF882) DUF4448 PF14610.6 ETO21822.1 - 0.001 18.9 0.0 0.0017 18.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) DUF5305 PF17231.2 ETO21822.1 - 0.0043 16.5 0.9 0.017 14.5 0.0 2.2 3 0 0 3 3 3 1 Family of unknown function (DUF5305) KCT2 PF17818.1 ETO21822.1 - 0.015 15.5 0.1 0.052 13.7 0.0 1.9 2 0 0 2 2 2 0 Keratinocyte-associated gene product KilA-N PF04383.13 ETO21822.1 - 0.02 14.8 1.8 0.23 11.3 0.2 2.9 2 1 0 2 2 2 0 KilA-N domain DUF1180 PF06679.12 ETO21822.1 - 0.088 13.2 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) Peptidase_C62 PF12380.8 ETO21823.1 - 0.017 14.2 0.1 0.024 13.7 0.1 1.1 1 0 0 1 1 1 0 Gill-associated viral 3C-like peptidase Tubulin PF00091.25 ETO21824.1 - 1.8e-54 184.9 0.0 1.3e-53 182.1 0.0 2.0 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO21824.1 - 1.8e-11 44.3 0.0 3.2e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.25 ETO21824.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) SID-1_RNA_chan PF13965.6 ETO21825.1 - 10 4.4 14.4 11 4.3 13.3 1.6 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Actin PF00022.19 ETO21826.1 - 3.7e-119 398.0 0.0 8.2e-119 396.8 0.0 1.5 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO21826.1 - 0.035 12.9 0.2 0.11 11.3 0.2 1.7 1 1 0 1 1 1 0 MreB/Mbl protein cNMP_binding PF00027.29 ETO21829.1 - 2e-05 24.6 0.0 4e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain TRM13 PF05206.14 ETO21829.1 - 0.038 13.5 0.4 0.038 13.5 0.4 1.9 2 0 0 2 2 2 0 Methyltransferase TRM13 DUF3472 PF11958.8 ETO21830.1 - 0.027 14.9 1.2 0.031 14.8 0.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3472) HPD PF05044.12 ETO21830.1 - 0.045 13.6 0.3 0.059 13.2 0.3 1.5 1 1 0 1 1 1 0 Homeo-prospero domain Foie-gras_1 PF11817.8 ETO21830.1 - 0.055 13.0 0.6 0.064 12.8 0.6 1.1 1 0 0 1 1 1 0 Foie gras liver health family 1 PqiA PF04403.13 ETO21831.1 - 1.6e-06 28.0 4.2 1.6e-06 28.0 4.2 1.6 2 0 0 2 2 2 1 Paraquat-inducible protein A Peptidase_C14 PF00656.22 ETO21832.1 - 1.3e-07 31.9 2.0 7.8e-07 29.3 2.0 1.9 1 1 0 1 1 1 1 Caspase domain DUF4488 PF14869.6 ETO21832.1 - 0.04 13.8 1.6 0.091 12.7 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4488) DUF4709 PF15821.5 ETO21833.1 - 0.065 13.5 1.1 0.11 12.7 0.4 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4709) D123 PF07065.14 ETO21834.1 - 5.6e-11 42.1 0.4 7.2e-11 41.8 0.4 1.3 1 0 0 1 1 1 1 D123 Glyco_hydro_47 PF01532.20 ETO21835.1 - 9.3e-26 90.7 0.1 1.3e-25 90.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 XRN_M PF17846.1 ETO21836.1 - 4.5 6.1 4.8 4.3 6.2 3.5 1.5 2 0 0 2 2 2 0 Xrn1 helical domain zf-CCCH PF00642.24 ETO21837.1 - 3.1e-07 30.1 3.9 3.1e-07 30.1 3.9 3.2 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO21837.1 - 3e-06 26.9 10.3 0.00048 19.9 2.6 2.9 3 0 0 3 3 3 2 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETO21837.1 - 2e-05 24.5 13.0 0.00077 19.4 5.2 2.5 2 0 0 2 2 2 2 Zinc finger domain zf-CCCH_2 PF14608.6 ETO21837.1 - 8.7e-05 22.8 7.3 0.11 13.0 1.9 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger PA PF02225.22 ETO21837.1 - 0.0046 16.9 0.1 0.013 15.6 0.1 1.7 1 0 0 1 1 1 1 PA domain Torus PF16131.5 ETO21837.1 - 0.028 15.1 4.2 0.028 15.1 4.2 2.7 2 1 1 3 3 3 0 Torus domain ORC6 PF05460.13 ETO21837.1 - 0.11 11.7 5.3 0.26 10.5 0.5 2.2 2 0 0 2 2 2 0 Origin recognition complex subunit 6 (ORC6) Herpes_capsid PF06112.11 ETO21837.1 - 5.1 7.1 12.8 12 6.0 12.8 1.6 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein CLASP_N PF12348.8 ETO21838.1 - 3.1e-08 33.4 0.1 5.3e-08 32.7 0.1 1.3 1 0 0 1 1 1 1 CLASP N terminal Vac14_Fab1_bd PF12755.7 ETO21838.1 - 0.023 15.3 0.1 0.29 11.7 0.0 2.5 2 0 0 2 2 2 0 Vacuolar 14 Fab1-binding region EF-hand_7 PF13499.6 ETO21838.1 - 0.072 13.5 0.1 0.32 11.5 0.1 2.2 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO21838.1 - 0.11 12.5 2.8 0.38 10.8 0.2 3.1 3 0 0 3 3 3 0 EF-hand domain Snf7 PF03357.21 ETO21839.1 - 1.8e-14 53.7 10.1 1.8e-14 53.7 10.1 1.7 2 0 0 2 2 2 1 Snf7 DUF3567 PF12091.8 ETO21839.1 - 0.027 14.6 1.3 0.21 11.7 0.3 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3567) ATP-synt_G PF04718.15 ETO21839.1 - 0.055 14.3 1.4 4.6 8.1 0.5 2.3 1 1 1 2 2 2 0 Mitochondrial ATP synthase g subunit DUF1957 PF09210.11 ETO21839.1 - 0.064 13.7 1.6 0.17 12.3 0.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF1957) Cob_adeno_trans PF01923.18 ETO21839.1 - 0.1 12.7 1.9 2.7 8.1 0.1 2.5 2 1 1 3 3 3 0 Cobalamin adenosyltransferase PID PF00640.23 ETO21841.1 - 0.056 13.5 2.9 0.082 12.9 2.9 1.2 1 0 0 1 1 1 0 Phosphotyrosine interaction domain (PTB/PID) DUF1939 PF09154.10 ETO21841.1 - 4.6 7.5 8.0 36 4.6 6.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF1939) Pkinase PF00069.25 ETO21842.1 - 5.5e-63 212.8 0.0 6.7e-63 212.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21842.1 - 9.9e-35 120.1 0.0 1.3e-34 119.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO21842.1 - 0.00037 19.9 0.0 0.0016 17.8 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ETO21842.1 - 0.021 14.2 0.0 0.035 13.4 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO21842.1 - 0.025 14.1 0.2 0.039 13.5 0.2 1.2 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL PUD1_2 PF18457.1 ETO21844.1 - 6.7e-11 42.5 0.2 1.3e-08 35.0 0.6 2.4 1 1 1 2 2 2 2 Up-Regulated in long-lived daf-2 MarC PF01914.17 ETO21845.1 - 0.7 9.3 5.5 0.78 9.1 5.2 1.3 1 1 0 1 1 1 0 MarC family integral membrane protein TMEMspv1-c74-12 PF11044.8 ETO21845.1 - 2.6 8.1 5.9 0.87 9.6 1.2 2.1 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein DUF924 PF06041.11 ETO21846.1 - 1.5e-49 168.5 0.2 1.9e-49 168.3 0.2 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF924) TB2_DP1_HVA22 PF03134.19 ETO21847.1 - 2.1e-17 62.8 17.5 1.4e-09 37.7 5.4 3.1 3 0 0 3 3 3 2 TB2/DP1, HVA22 family Sortilin-Vps10 PF15902.5 ETO21849.1 - 3.9e-06 25.9 0.2 8e-06 24.9 0.1 1.4 1 1 1 2 2 2 2 Sortilin, neurotensin receptor 3, PSII_BNR PF14870.6 ETO21849.1 - 0.00042 19.7 2.4 0.38 10.0 0.3 2.4 1 1 1 2 2 2 2 Photosynthesis system II assembly factor YCF48 BNR PF02012.20 ETO21849.1 - 0.024 14.6 14.8 2.8 8.3 1.3 3.8 3 0 0 3 3 3 0 BNR/Asp-box repeat DUF2591 PF10765.9 ETO21849.1 - 0.1 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2591) CHB_HEX_C PF03174.13 ETO21849.1 - 0.48 10.4 1.6 11 6.0 0.0 3.3 4 0 0 4 4 4 0 Chitobiase/beta-hexosaminidase C-terminal domain PITH PF06201.13 ETO21850.1 - 6.5e-23 81.6 1.6 1.4e-22 80.6 1.6 1.6 1 1 0 1 1 1 1 PITH domain Eapp_C PF10238.9 ETO21851.1 - 0.039 14.0 3.6 0.047 13.8 3.6 1.2 1 0 0 1 1 1 0 E2F-associated phosphoprotein Presenilin PF01080.17 ETO21851.1 - 0.25 10.1 10.9 0.29 9.9 10.9 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO21851.1 - 0.57 9.0 8.3 0.61 8.9 8.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter F-protein PF00469.20 ETO21851.1 - 0.93 9.0 8.0 1.6 8.3 8.0 1.3 1 0 0 1 1 1 0 Negative factor, (F-Protein) or Nef DDHD PF02862.17 ETO21851.1 - 0.94 9.6 6.6 1.1 9.4 6.6 1.2 1 0 0 1 1 1 0 DDHD domain SASRP1 PF15160.6 ETO21851.1 - 0.95 9.1 7.1 1.3 8.6 7.1 1.2 1 0 0 1 1 1 0 Spermatogenesis-associated serine-rich protein 1 DUF4407 PF14362.6 ETO21851.1 - 1.3 8.3 8.5 1.7 7.9 8.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1980 PF09323.10 ETO21851.1 - 2.3 8.1 5.2 3.6 7.4 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Zip PF02535.22 ETO21851.1 - 4 6.6 5.5 5.4 6.1 5.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter WTX PF09422.10 ETO21852.1 - 0.32 10.0 13.4 0.43 9.6 13.4 1.2 1 0 0 1 1 1 0 WTX protein Lin-8 PF03353.15 ETO21852.1 - 0.33 10.5 16.5 0.47 10.0 16.5 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist QueC PF06508.13 ETO21852.1 - 0.85 9.1 6.6 0.2 11.1 0.4 2.2 1 1 1 2 2 2 0 Queuosine biosynthesis protein QueC GREB1 PF15782.5 ETO21852.1 - 2.3 5.2 26.9 3 4.9 26.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer IHABP4_N PF16174.5 ETO21852.1 - 2.8 8.5 20.7 4 8.0 9.7 2.1 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal EFTUD2 PF16004.5 ETO21852.1 - 6 7.5 10.4 1.6 9.3 0.7 2.4 2 0 0 2 2 2 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus PAT1 PF09770.9 ETO21852.1 - 7.8 4.6 32.9 11 4.2 32.9 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 BAF1_ABF1 PF04684.13 ETO21852.1 - 9.1 5.2 19.5 11 4.9 19.5 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor EXOSC1 PF10447.9 ETO21855.1 - 0.55 10.9 5.0 0.2 12.3 1.7 1.7 2 0 0 2 2 2 0 Exosome component EXOSC1/CSL4 La PF05383.17 ETO21857.1 - 3.3e-19 68.7 0.1 5.9e-19 67.9 0.1 1.4 1 0 0 1 1 1 1 La domain Coilin_N PF15862.5 ETO21857.1 - 1.4e-09 37.9 0.1 5.3e-07 29.5 0.0 2.8 2 1 1 3 3 3 1 Coilin N-terminus RRM_1 PF00076.22 ETO21857.1 - 0.0013 18.5 0.0 0.016 15.0 0.0 2.4 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) LAP1C PF05609.12 ETO21857.1 - 0.17 10.9 20.8 0.26 10.3 20.8 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF1218 PF06749.12 ETO21857.1 - 1.1 9.8 4.5 2.2 8.9 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1218) DUF3446 PF11928.8 ETO21857.1 - 1.3 9.4 7.0 1.3 9.4 2.6 2.3 2 0 0 2 2 2 0 Early growth response N-terminal domain BSMAP PF12280.8 ETO21857.1 - 2.7 8.2 18.1 1.3 9.2 1.3 2.8 1 1 1 2 2 2 0 Brain specific membrane anchored protein SAM_2 PF07647.17 ETO21858.1 - 1.3e-07 31.6 0.1 2.4e-07 30.8 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO21858.1 - 1.5e-06 28.5 0.0 3.4e-06 27.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO21859.1 - 8.4e-34 115.0 20.7 3.9e-07 30.7 0.4 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21859.1 - 2e-11 44.1 4.7 0.1 12.9 0.1 5.0 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO21859.1 - 2.3e-09 36.5 11.8 0.0034 16.1 0.2 4.7 2 2 2 4 4 4 4 Nucleoporin Nup120/160 PH PF00169.29 ETO21860.1 - 6.2e-11 42.7 0.9 1.7e-10 41.4 0.9 1.8 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO21860.1 - 1e-09 38.4 0.5 2.6e-09 37.1 0.5 1.7 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO21860.1 - 0.0071 16.6 0.5 0.016 15.5 0.5 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO21860.1 - 0.025 15.0 2.6 0.38 11.2 2.6 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain PH_15 PF17339.2 ETO21860.1 - 0.14 12.1 0.6 0.36 10.7 0.6 1.7 1 0 0 1 1 1 0 PH domain FAM176 PF14851.6 ETO21860.1 - 0.29 10.8 0.0 0.29 10.8 0.0 3.0 3 0 0 3 3 3 0 FAM176 family PIH1 PF08190.12 ETO21861.1 - 0.0071 15.8 0.0 0.009 15.5 0.0 1.1 1 0 0 1 1 1 1 PIH1 N-terminal domain DUF2207 PF09972.9 ETO21861.1 - 0.0081 15.0 0.2 0.009 14.8 0.2 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Orf78 PF06024.12 ETO21861.1 - 0.15 12.4 0.1 0.2 12.0 0.1 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF4834 PF16118.5 ETO21861.1 - 3.4 8.7 6.6 0.75 10.8 3.3 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) HlyD_2 PF12700.7 ETO21861.1 - 5.8 5.5 7.7 7.8 5.1 7.7 1.1 1 0 0 1 1 1 0 HlyD family secretion protein DSPc PF00782.20 ETO21862.1 - 1.2e-24 86.6 0.1 2e-24 85.9 0.1 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain zf-RanBP PF00641.18 ETO21862.1 - 5.3e-06 25.7 5.0 1.1e-05 24.6 5.0 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Init_tRNA_PT PF04179.12 ETO21862.1 - 7.9e-05 22.9 0.0 0.00017 21.8 0.0 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ETO21862.1 - 0.0002 21.0 0.0 0.0003 20.4 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase2 PF03162.13 ETO21862.1 - 0.0032 17.1 0.1 0.0051 16.4 0.1 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Vps36-NZF-N PF16988.5 ETO21862.1 - 0.2 11.0 5.1 0.79 9.2 5.2 2.0 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain KdpC PF02669.15 ETO21863.1 - 0.031 14.1 1.2 0.092 12.6 1.2 1.7 1 0 0 1 1 1 0 K+-transporting ATPase, c chain DUF423 PF04241.15 ETO21863.1 - 5.7 7.2 6.8 6.3 7.1 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF423) Androgen_recep PF02166.16 ETO21863.1 - 7 5.4 19.8 0.22 10.3 12.1 2.1 2 0 0 2 2 2 0 Androgen receptor Ribonuclease_3 PF00636.26 ETO21864.1 - 7.9e-12 45.7 0.0 2.8e-11 43.9 0.0 1.9 2 0 0 2 2 2 1 Ribonuclease III domain WD40 PF00400.32 ETO21865.1 - 5.9e-41 137.7 34.1 1.3e-08 35.4 0.4 8.1 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21865.1 - 3.6e-13 49.6 4.9 0.035 14.4 0.0 6.1 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO21865.1 - 2.6e-09 36.3 12.0 0.0015 17.3 0.3 5.8 2 1 4 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO21865.1 - 4e-06 26.9 1.2 0.092 12.6 0.1 4.0 2 2 0 3 3 3 2 Eukaryotic translation initiation factor eIF2A Marek_SORF3 PF07153.11 ETO21865.1 - 0.052 12.9 0.9 4.2 6.6 0.1 2.9 2 2 0 2 2 2 0 Marek's disease-like virus SORF3 protein HMMR_N PF15905.5 ETO21865.1 - 0.95 8.9 20.2 1.4 8.3 20.2 1.3 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal TMPIT PF07851.13 ETO21865.1 - 5.3 6.2 11.2 8.2 5.6 11.2 1.4 1 0 0 1 1 1 0 TMPIT-like protein 2OG-FeII_Oxy_3 PF13640.6 ETO21867.1 - 0.0014 19.5 0.0 0.0021 18.9 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily zf-C2H2_4 PF13894.6 ETO21868.1 - 0.015 16.0 0.6 0.052 14.4 0.6 2.0 1 0 0 1 1 1 0 C2H2-type zinc finger zf-met PF12874.7 ETO21868.1 - 0.03 14.7 0.5 0.086 13.3 0.1 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ETO21868.1 - 0.043 13.6 0.2 0.083 12.7 0.2 1.4 1 0 0 1 1 1 0 zinc-finger C2H2-type zf-C2H2 PF00096.26 ETO21868.1 - 0.076 13.5 0.8 0.076 13.5 0.8 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type Lin-8 PF03353.15 ETO21869.1 - 1.2 8.6 5.2 1.4 8.4 5.2 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Polyketide_cyc2 PF10604.9 ETO21870.1 - 0.0009 19.5 0.0 0.0017 18.7 0.0 1.7 1 1 0 1 1 1 1 Polyketide cyclase / dehydrase and lipid transport Elf4 PF07011.11 ETO21870.1 - 0.17 11.8 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 Early Flowering 4 domain Cu-oxidase_2 PF07731.14 ETO21872.1 - 6.8e-09 35.6 2.9 5.4e-07 29.4 2.3 2.9 2 1 0 2 2 2 2 Multicopper oxidase DUF5109 PF17134.4 ETO21873.1 - 0.0085 16.0 4.5 0.22 11.4 0.9 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5109) DUF1308 PF07000.11 ETO21873.1 - 0.13 12.2 4.6 1.1 9.1 0.7 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1308) L27_1 PF09058.10 ETO21873.1 - 0.13 12.2 0.4 0.98 9.4 0.1 2.4 2 0 0 2 2 2 0 L27_1 ETRAMP PF09716.10 ETO21873.1 - 6.1 7.0 12.6 1.9 8.6 4.2 3.5 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Ras PF00071.22 ETO21875.1 - 1.7e-16 60.2 0.2 2.5e-16 59.7 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO21875.1 - 2.7e-14 53.4 0.0 3.4e-14 53.1 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO21875.1 - 1e-05 25.6 0.0 1.3e-05 25.3 0.0 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO21875.1 - 0.00037 20.4 0.0 0.00045 20.2 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase Septin PF00735.18 ETO21875.1 - 0.0011 18.4 0.0 0.0018 17.6 0.0 1.3 1 0 0 1 1 1 1 Septin Arf PF00025.21 ETO21875.1 - 0.0012 18.3 0.1 0.0015 18.0 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_24 PF13479.6 ETO21875.1 - 0.0019 18.0 0.0 0.002 17.9 0.0 1.2 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO21875.1 - 0.0029 18.1 0.1 0.0034 17.9 0.1 1.4 1 1 0 1 1 1 1 ABC transporter NACHT PF05729.12 ETO21875.1 - 0.0075 16.2 0.1 0.017 15.0 0.0 1.6 2 0 0 2 2 2 1 NACHT domain MCM PF00493.23 ETO21875.1 - 0.009 15.1 0.0 0.011 14.8 0.0 1.2 1 0 0 1 1 1 1 MCM P-loop domain AAA_7 PF12775.7 ETO21875.1 - 0.011 15.2 0.1 0.015 14.8 0.1 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ETO21875.1 - 0.011 16.0 0.0 0.016 15.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO21875.1 - 0.012 16.0 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 ETO21875.1 - 0.016 14.6 0.0 0.022 14.2 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein DUF815 PF05673.13 ETO21875.1 - 0.017 14.3 0.0 0.017 14.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_5 PF07728.14 ETO21875.1 - 0.019 15.0 0.0 0.025 14.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) IIGP PF05049.13 ETO21875.1 - 0.038 13.1 0.0 0.053 12.6 0.0 1.1 1 0 0 1 1 1 0 Interferon-inducible GTPase (IIGP) RNA_helicase PF00910.22 ETO21875.1 - 0.047 14.1 0.0 0.065 13.6 0.0 1.3 1 0 0 1 1 1 0 RNA helicase FeoB_N PF02421.18 ETO21875.1 - 0.06 12.9 0.0 0.075 12.6 0.0 1.2 1 0 0 1 1 1 0 Ferrous iron transport protein B AAA_29 PF13555.6 ETO21875.1 - 0.12 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain CsrA PF02599.16 ETO21875.1 - 0.3 11.1 1.6 0.38 10.7 0.1 1.8 2 0 0 2 2 2 0 Global regulator protein family Secretin_N_2 PF07655.13 ETO21876.1 - 0.062 13.8 6.8 0.1 13.2 6.8 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain F-box_4 PF15966.5 ETO21876.1 - 0.12 12.3 1.0 0.21 11.5 1.0 1.4 1 0 0 1 1 1 0 F-box DUF3817 PF12823.7 ETO21876.1 - 0.31 11.9 4.7 0.59 11.0 4.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3817) Orf78 PF06024.12 ETO21876.1 - 4.3 7.7 9.9 40 4.6 7.7 2.2 2 0 0 2 2 2 0 Orf78 (ac78) tRNA-Thr_ED PF08915.11 ETO21877.1 - 0.27 11.3 4.0 0.42 10.7 4.0 1.3 1 0 0 1 1 1 0 Archaea-specific editing domain of threonyl-tRNA synthetase DUF809 PF05663.11 ETO21877.1 - 0.63 10.2 2.5 1.1 9.4 2.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF809) Paramyxo_ncap PF00973.19 ETO21877.1 - 1.5 7.7 7.8 2.1 7.2 7.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PH PF00169.29 ETO21878.1 - 8.1e-12 45.6 2.9 1.4e-11 44.9 2.9 1.4 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO21878.1 - 2.7e-07 30.6 0.5 4.7e-07 29.9 0.5 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO21878.1 - 0.00059 20.2 8.0 0.0069 16.8 1.8 2.8 2 1 1 3 3 3 2 Pleckstrin homology domain PH_6 PF15406.6 ETO21878.1 - 0.0078 16.5 0.0 0.016 15.5 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain Peroxin-3 PF04882.12 ETO21879.1 - 2.2 7.2 10.1 3.1 6.7 10.1 1.1 1 0 0 1 1 1 0 Peroxin-3 PNISR PF15996.5 ETO21879.1 - 3.9 7.7 7.8 5.8 7.1 7.8 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Presenilin PF01080.17 ETO21879.1 - 4.8 5.8 7.6 6.3 5.4 7.6 1.1 1 0 0 1 1 1 0 Presenilin Ashwin PF15323.6 ETO21879.1 - 7.7 6.5 15.1 12 5.9 15.1 1.2 1 0 0 1 1 1 0 Developmental protein DUF1803 PF08820.10 ETO21880.1 - 0.00088 19.3 1.1 0.00088 19.3 1.1 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1803) GCD14 PF08704.10 ETO21880.1 - 0.11 12.1 1.3 0.2 11.3 1.3 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit DHHC PF01529.20 ETO21881.1 - 0.0003 20.9 7.9 0.0005 20.2 7.9 1.3 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF2784 PF10861.8 ETO21881.1 - 0.011 15.8 2.2 0.022 14.8 2.2 1.5 1 0 0 1 1 1 0 Protein of Unknown function (DUF2784) Methyltransf_25 PF13649.6 ETO21882.1 - 0.0021 18.8 0.0 0.009 16.7 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_18 PF12847.7 ETO21882.1 - 0.0036 17.3 0.0 0.0088 16.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO21882.1 - 0.074 13.7 0.0 0.22 12.2 0.0 1.8 1 0 0 1 1 1 0 Methyltransferase domain Secretin_N_2 PF07655.13 ETO21882.1 - 0.98 10.0 27.8 0.38 11.3 24.6 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain Presenilin PF01080.17 ETO21882.1 - 1.7 7.3 5.0 2.2 7.0 5.0 1.1 1 0 0 1 1 1 0 Presenilin GCD14 PF08704.10 ETO21882.1 - 3.2 7.4 5.1 2.5 7.7 3.2 1.8 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Anoctamin PF04547.12 ETO21883.1 - 2.1e-29 102.7 7.5 2.6e-29 102.4 7.5 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF2157 PF09925.9 ETO21883.1 - 0.048 13.5 1.7 0.069 12.9 1.7 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) Anoctamin PF04547.12 ETO21884.1 - 1.7e-33 116.2 0.9 1.7e-33 116.2 0.9 1.4 2 0 0 2 2 2 1 Calcium-activated chloride channel LigB PF02900.18 ETO21886.1 - 8.4e-16 57.8 0.0 3.9e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 Catalytic LigB subunit of aromatic ring-opening dioxygenase Memo PF01875.17 ETO21886.1 - 0.0097 15.1 0.1 0.037 13.2 0.0 2.0 1 1 1 2 2 2 1 Memo-like protein Glycolytic PF00274.19 ETO21887.1 - 4.3e-54 183.6 0.0 5.3e-54 183.3 0.0 1.1 1 0 0 1 1 1 1 Fructose-bisphosphate aldolase class-I SR-25 PF10500.9 ETO21888.1 - 0.00019 21.1 17.2 0.00019 21.1 17.2 6.6 3 2 3 6 6 6 1 Nuclear RNA-splicing-associated protein Menin PF05053.13 ETO21889.1 - 0.099 11.0 2.5 0.12 10.7 2.5 1.2 1 0 0 1 1 1 0 Menin EXS PF03124.14 ETO21890.1 - 5.4e-14 52.3 21.0 9.1e-14 51.5 21.0 1.4 1 0 0 1 1 1 1 EXS family DUF4519 PF15012.6 ETO21891.1 - 3.1 8.0 5.1 39 4.5 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) DUF3276 PF11680.8 ETO21892.1 - 0.13 12.4 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3276) RepA1_leader PF08048.12 ETO21892.1 - 1.6 9.1 5.1 5.6 7.3 5.1 2.0 1 0 0 1 1 1 0 Tap RepA1 leader peptide RRM_1 PF00076.22 ETO21893.1 - 4.1e-13 48.9 0.2 1.1e-12 47.6 0.2 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO21893.1 - 0.007 16.2 0.0 0.013 15.3 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif CDC45 PF02724.14 ETO21893.1 - 0.095 11.0 14.3 0.1 10.9 14.3 1.0 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO21893.1 - 0.28 11.0 19.9 0.36 10.6 19.9 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Tim54 PF11711.8 ETO21893.1 - 0.39 9.5 11.7 0.44 9.3 11.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO21893.1 - 0.39 9.9 4.5 0.38 9.9 4.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 ETO21893.1 - 0.45 9.4 6.7 0.49 9.3 6.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Nop14 PF04147.12 ETO21893.1 - 0.53 8.4 21.0 0.6 8.3 21.0 1.0 1 0 0 1 1 1 0 Nop14-like family FAM60A PF15396.6 ETO21893.1 - 0.59 10.1 3.3 0.59 10.1 3.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ETO21893.1 - 0.62 8.8 11.6 0.69 8.6 11.6 1.1 1 0 0 1 1 1 0 Presenilin Merozoite_SPAM PF07133.11 ETO21893.1 - 0.7 9.9 38.0 0.98 9.4 38.0 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Pex14_N PF04695.13 ETO21893.1 - 0.71 10.5 6.6 0.98 10.1 6.6 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DDRGK PF09756.9 ETO21893.1 - 1 8.9 24.2 0.88 9.1 22.9 1.5 2 0 0 2 2 2 0 DDRGK domain DDHD PF02862.17 ETO21893.1 - 1.1 9.4 4.2 1.2 9.3 4.2 1.2 1 0 0 1 1 1 0 DDHD domain DUF966 PF06136.13 ETO21893.1 - 1.1 8.9 9.7 1.2 8.8 9.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) DUF2151 PF10221.9 ETO21893.1 - 1.7 7.2 9.3 1.7 7.2 9.3 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator Plasmodium_Vir PF05795.11 ETO21893.1 - 2 7.7 8.5 2.6 7.4 8.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein RRN3 PF05327.11 ETO21893.1 - 2.7 6.4 10.8 3.1 6.2 10.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Spore_coat_CotO PF14153.6 ETO21893.1 - 2.7 7.9 23.9 3.7 7.4 23.9 1.2 1 0 0 1 1 1 0 Spore coat protein CotO DUF4407 PF14362.6 ETO21893.1 - 3.3 7.0 6.9 3.9 6.8 6.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Connexin PF00029.19 ETO21893.1 - 3.7 7.3 6.5 5.5 6.7 6.5 1.3 1 0 0 1 1 1 0 Connexin SLC12 PF03522.15 ETO21893.1 - 4.1 6.3 9.0 4.9 6.1 9.0 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CLN3 PF02487.17 ETO21893.1 - 7.7 5.4 5.0 9.2 5.2 5.0 1.1 1 0 0 1 1 1 0 CLN3 protein Pox_RNA_Pol_19 PF05320.12 ETO21893.1 - 9.7 6.1 10.4 15 5.5 10.4 1.3 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit WD40 PF00400.32 ETO21894.1 - 2.5e-47 157.9 22.3 1.6e-09 38.2 0.1 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21894.1 - 2.5e-14 53.4 1.0 0.0052 17.1 0.0 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21894.1 - 1.8e-12 46.9 1.6 0.11 11.4 0.0 5.3 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO21894.1 - 8.4e-09 35.6 0.0 0.0019 18.1 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO21894.1 - 1.2e-05 24.8 0.5 7.8e-05 22.1 0.0 2.4 1 1 2 3 3 3 1 WD40-like domain Arena_nucleocap PF00843.17 ETO21894.1 - 0.0061 15.5 0.1 1.5 7.6 0.0 2.2 2 0 0 2 2 2 2 Arenavirus nucleocapsid N-terminal domain NHL PF01436.21 ETO21894.1 - 0.014 15.4 1.5 15 5.9 0.1 3.6 3 0 0 3 3 3 0 NHL repeat VID27 PF08553.10 ETO21894.1 - 0.028 13.5 0.0 0.59 9.1 0.0 2.3 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ETO21894.1 - 0.037 12.6 0.2 0.71 8.3 0.0 2.4 1 1 2 3 3 3 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO21894.1 - 0.048 13.6 9.6 4.3 7.4 0.1 5.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat CHAP PF05257.16 ETO21894.1 - 0.051 14.2 0.9 6.6 7.4 0.2 3.6 2 1 2 4 4 4 0 CHAP domain DUF1406 PF07190.11 ETO21894.1 - 0.41 10.6 2.6 0.85 9.5 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1406) Pkinase PF00069.25 ETO21895.1 - 3.2e-22 79.2 0.0 1.6e-21 76.9 0.0 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21895.1 - 3.3e-06 26.6 0.0 2.8e-05 23.5 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ETO21895.1 - 0.063 12.9 0.1 0.19 11.3 0.0 1.9 2 0 0 2 2 2 0 RIO1 family APH PF01636.23 ETO21895.1 - 0.25 11.3 0.1 0.44 10.4 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family TMEM154 PF15102.6 ETO21896.1 - 8.2e-05 22.5 4.6 8.2e-05 22.5 4.6 1.8 1 1 1 2 2 2 1 TMEM154 protein family DUF4834 PF16118.5 ETO21896.1 - 0.00088 20.2 0.5 0.00088 20.2 0.5 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4834) TRP PF06011.12 ETO21896.1 - 0.0013 17.6 0.5 0.0015 17.4 0.5 1.1 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel Orf78 PF06024.12 ETO21896.1 - 0.0019 18.4 0.1 0.0019 18.4 0.1 1.8 3 0 0 3 3 2 1 Orf78 (ac78) Tetraspanin PF00335.20 ETO21896.1 - 0.0037 17.0 0.1 0.0044 16.8 0.1 1.1 1 0 0 1 1 1 1 Tetraspanin family RIFIN PF02009.16 ETO21896.1 - 0.0049 16.8 3.6 0.0049 16.8 3.6 1.8 1 1 1 2 2 2 1 Rifin Nucleoside_tran PF01733.18 ETO21896.1 - 0.0099 15.3 1.0 0.0099 15.3 1.0 1.6 1 1 1 2 2 2 1 Nucleoside transporter EVC2_like PF12297.8 ETO21896.1 - 0.012 14.3 0.2 0.016 13.9 0.2 1.1 1 0 0 1 1 1 0 Ellis van Creveld protein 2 like protein Peptidase_M56 PF05569.11 ETO21896.1 - 0.014 14.6 0.2 0.019 14.2 0.2 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 SID-1_RNA_chan PF13965.6 ETO21896.1 - 0.02 13.4 0.7 0.023 13.1 0.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LRR19-TM PF15176.6 ETO21896.1 - 0.036 14.1 0.0 0.06 13.3 0.0 1.4 1 0 0 1 1 1 0 Leucine-rich repeat family 19 TM domain Tmemb_9 PF05434.11 ETO21896.1 - 0.036 14.0 0.0 0.057 13.3 0.0 1.3 1 0 0 1 1 1 0 TMEM9 DUF3139 PF11337.8 ETO21896.1 - 0.052 14.2 1.2 0.083 13.6 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DUF5385 PF17359.2 ETO21896.1 - 0.06 12.9 1.9 0.089 12.3 1.9 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Amnionless PF14828.6 ETO21896.1 - 0.095 11.5 0.2 0.11 11.3 0.2 1.1 1 0 0 1 1 1 0 Amnionless DUF4711 PF15829.5 ETO21896.1 - 0.098 12.6 1.6 0.17 11.8 1.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4711) Stevor PF17410.2 ETO21896.1 - 0.12 11.9 1.8 0.2 11.2 1.8 1.3 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame Vpu PF00558.19 ETO21896.1 - 0.15 11.9 0.5 0.24 11.2 0.5 1.3 1 0 0 1 1 1 0 Vpu protein PV-1 PF06637.11 ETO21896.1 - 0.22 10.3 0.1 0.61 8.8 0.1 1.7 2 0 0 2 2 2 0 PV-1 protein (PLVAP) DUF5305 PF17231.2 ETO21896.1 - 1.2 8.5 9.0 0.027 13.9 2.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5305) Shisa PF13908.6 ETO21896.1 - 1.5 9.1 9.6 0.36 11.1 0.1 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Mid2 PF04478.12 ETO21896.1 - 1.7 8.5 7.9 3 7.7 7.9 1.4 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Baculo_11_kDa PF06143.11 ETO21896.1 - 5.9 6.5 8.2 12 5.6 8.2 1.6 1 1 0 1 1 1 0 Baculovirus 11 kDa family Calpain_III PF01067.22 ETO21897.1 - 0.056 13.7 0.0 0.35 11.1 0.0 2.0 2 0 0 2 2 2 0 Calpain large subunit, domain III SatD PF16264.5 ETO21897.1 - 0.063 12.9 0.0 0.099 12.2 0.0 1.3 1 0 0 1 1 1 0 SatD family (SatD) SH3_1 PF00018.28 ETO21898.1 - 3.8e-32 109.6 4.4 1.1e-15 57.0 0.1 2.5 2 0 0 2 2 2 2 SH3 domain SH3_2 PF07653.17 ETO21898.1 - 3.3e-25 87.5 0.1 3.1e-15 55.6 0.0 2.5 2 0 0 2 2 2 2 Variant SH3 domain SH3_9 PF14604.6 ETO21898.1 - 1.6e-22 79.1 3.8 1.6e-10 40.7 0.1 2.4 2 0 0 2 2 2 2 Variant SH3 domain VHP PF02209.19 ETO21898.1 - 2.6e-15 56.2 1.3 2.6e-15 56.2 1.3 2.3 2 0 0 2 2 2 1 Villin headpiece domain SID-1_RNA_chan PF13965.6 ETO21898.1 - 0.0014 17.2 0.1 0.0019 16.7 0.1 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 SH3_10 PF17902.1 ETO21898.1 - 0.0089 16.1 0.0 0.28 11.3 0.0 2.4 2 0 0 2 2 2 1 SH3 domain DUF3104 PF11302.8 ETO21898.1 - 0.034 13.9 0.6 0.6 9.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3104) TMEM154 PF15102.6 ETO21898.1 - 0.035 14.0 1.7 0.035 14.0 1.7 2.8 2 1 0 2 2 1 0 TMEM154 protein family DUF5348 PF17295.2 ETO21898.1 - 0.15 12.0 0.2 0.37 10.7 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5348) RAP1 PF07218.11 ETO21898.1 - 4.2 5.5 9.2 6.4 4.9 9.2 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) Orf78 PF06024.12 ETO21898.1 - 7.6 6.9 13.5 0.13 12.6 2.7 2.6 2 1 1 3 3 3 0 Orf78 (ac78) Vps51 PF08700.11 ETO21899.1 - 3.4e-06 27.0 2.2 3.4e-06 27.0 2.2 2.0 2 0 0 2 2 2 1 Vps51/Vps67 MnmE_helical PF12631.7 ETO21899.1 - 0.00027 21.2 3.4 0.0004 20.6 3.4 1.2 1 0 0 1 1 1 1 MnmE helical domain Dor1 PF04124.12 ETO21899.1 - 0.0089 14.8 5.9 0.013 14.2 5.9 1.2 1 0 0 1 1 1 1 Dor1-like family COG5 PF10392.9 ETO21899.1 - 0.011 15.9 3.6 0.02 15.1 3.6 1.4 1 0 0 1 1 1 0 Golgi transport complex subunit 5 COG2 PF06148.11 ETO21899.1 - 0.018 15.1 4.2 0.039 14.0 4.2 1.5 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Sec8_exocyst PF04048.14 ETO21899.1 - 0.024 14.5 6.0 0.042 13.7 6.0 1.4 1 0 0 1 1 1 0 Sec8 exocyst complex component specific domain FAM76 PF16046.5 ETO21899.1 - 0.053 12.9 5.3 0.074 12.4 5.3 1.2 1 0 0 1 1 1 0 FAM76 protein RecX PF02631.16 ETO21899.1 - 0.057 13.9 0.4 0.11 13.0 0.4 1.4 1 0 0 1 1 1 0 RecX family Vps54_N PF10475.9 ETO21899.1 - 0.057 12.7 9.7 0.075 12.3 9.7 1.1 1 0 0 1 1 1 0 Vacuolar-sorting protein 54, of GARP complex DUF2203 PF09969.9 ETO21899.1 - 0.62 10.8 3.5 5.6 7.7 1.1 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1002 PF06207.11 ETO21899.1 - 1.5 8.3 8.0 4 6.9 7.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1002) RNA_pol_Rpb1_5 PF04998.17 ETO21899.1 - 2.3 7.6 5.1 3.2 7.1 5.1 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 Ank_2 PF12796.7 ETO21900.1 - 9.8e-34 115.8 5.6 2.2e-15 57.0 0.5 4.9 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO21900.1 - 1.1e-32 111.9 2.1 6.3e-11 42.6 0.1 6.6 4 1 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO21900.1 - 8.2e-25 86.6 6.0 5e-09 36.3 0.1 4.7 3 1 0 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO21900.1 - 8.8e-21 71.8 0.5 0.0012 19.2 0.1 7.5 8 0 0 8 8 8 4 Ankyrin repeat Ank PF00023.30 ETO21900.1 - 8.4e-20 70.3 0.2 0.00027 21.2 0.0 6.2 6 1 1 7 7 7 3 Ankyrin repeat IMP_cyclohyd PF07826.11 ETO21900.1 - 0.0087 15.7 0.0 0.015 14.9 0.0 1.4 1 0 0 1 1 1 1 IMP cyclohydrolase-like protein CUE PF02845.16 ETO21901.1 - 0.0011 18.7 0.1 0.0018 17.9 0.1 1.4 1 0 0 1 1 1 1 CUE domain Snf7 PF03357.21 ETO21902.1 - 4.5e-11 42.6 20.3 5.7e-11 42.3 20.3 1.1 1 0 0 1 1 1 1 Snf7 Med8 PF10232.9 ETO21902.1 - 0.024 14.2 0.4 0.024 14.2 0.4 2.6 2 1 1 3 3 3 0 Mediator of RNA polymerase II transcription complex subunit 8 ThiC_Rad_SAM PF01964.18 ETO21902.1 - 0.026 13.3 3.3 0.029 13.2 3.3 1.1 1 0 0 1 1 1 0 Radical SAM ThiC family DDE_Tnp_ISL3 PF01610.17 ETO21902.1 - 0.044 13.5 6.9 0.05 13.3 6.6 1.3 1 1 0 1 1 1 0 Transposase PHM7_cyt PF14703.6 ETO21902.1 - 0.84 9.8 7.7 1.1 9.4 7.7 1.3 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter LOH1CR12 PF10158.9 ETO21902.1 - 8.2 6.5 10.0 3 7.9 3.6 2.1 1 1 1 2 2 2 0 Tumour suppressor protein HSD3 PF15244.6 ETO21906.1 - 0.0039 16.8 7.4 0.0047 16.5 7.4 1.0 1 0 0 1 1 1 1 Spermatogenesis-associated protein 7, or HSD3 SAM35 PF10806.8 ETO21906.1 - 0.062 13.6 1.7 0.075 13.3 1.7 1.2 1 0 0 1 1 1 0 SAM35, subunit of SAM coomplex RRM_1 PF00076.22 ETO21907.1 - 3.3e-25 87.7 0.1 5.5e-12 45.3 0.1 2.0 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO21907.1 - 0.00019 21.4 0.0 0.0012 18.8 0.0 1.9 1 1 1 2 2 2 1 RNA binding motif RNA_bind PF08675.11 ETO21907.1 - 0.0002 21.3 0.0 0.0021 18.0 0.0 2.3 2 1 0 2 2 2 1 RNA binding domain Nup35_RRM_2 PF14605.6 ETO21907.1 - 0.0033 17.4 0.0 0.38 10.8 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif DUF4283 PF14111.6 ETO21907.1 - 0.01 15.3 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) RRM_5 PF13893.6 ETO21907.1 - 0.11 12.1 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Amidohydro_2 PF04909.14 ETO21909.1 - 0.00016 21.6 0.0 0.00019 21.3 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase SPOUT_MTase PF02590.17 ETO21909.1 - 0.022 14.7 1.3 0.036 14.0 1.3 1.3 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase Peptidase_S49_N PF08496.10 ETO21909.1 - 0.2 11.7 2.0 0.25 11.4 2.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Amidohydro_2 PF04909.14 ETO21910.1 - 0.0032 17.3 0.0 0.015 15.1 0.0 1.9 1 1 0 1 1 1 1 Amidohydrolase Tubulin PF00091.25 ETO21912.1 - 5.1e-23 82.3 0.0 5.6e-23 82.2 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain SAP PF02037.27 ETO21913.1 - 6e-12 45.0 0.1 2.1e-11 43.3 0.1 2.0 1 0 0 1 1 1 1 SAP domain TPT PF03151.16 ETO21914.1 - 2.5e-09 36.9 19.4 4.6e-09 36.0 19.4 1.4 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ETO21914.1 - 0.11 12.7 40.7 1.3 9.2 11.4 3.5 3 1 1 4 4 4 0 EamA-like transporter family HA2 PF04408.23 ETO21916.1 - 1.2e-20 73.8 0.0 2.1e-20 73.0 0.0 1.5 1 0 0 1 1 1 1 Helicase associated domain (HA2) DEAD PF00270.29 ETO21916.1 - 8.9e-13 48.4 0.5 1.4e-12 47.7 0.5 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO21916.1 - 6.7e-11 42.5 0.1 1.9e-10 41.0 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ETO21916.1 - 2e-08 34.5 0.0 4.9e-08 33.2 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_19 PF13245.6 ETO21916.1 - 6.2e-07 29.8 0.3 1.3e-06 28.8 0.3 1.5 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ETO21916.1 - 2e-05 24.6 0.5 5.3e-05 23.3 0.5 1.7 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETO21916.1 - 3.6e-05 23.6 0.1 6.6e-05 22.7 0.1 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO21916.1 - 0.00042 20.6 0.0 0.0013 19.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain FtsK_SpoIIIE PF01580.18 ETO21916.1 - 0.00061 19.2 0.1 0.0013 18.2 0.1 1.5 1 0 0 1 1 1 1 FtsK/SpoIIIE family SRP54 PF00448.22 ETO21916.1 - 0.00098 18.8 1.0 0.0028 17.3 1.0 1.8 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain T2SSE PF00437.20 ETO21916.1 - 0.002 17.2 0.1 0.0038 16.3 0.1 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein NACHT PF05729.12 ETO21916.1 - 0.0036 17.2 0.2 0.01 15.7 0.1 1.8 2 0 0 2 2 2 1 NACHT domain UvrD-helicase PF00580.21 ETO21916.1 - 0.004 16.7 0.1 0.0071 15.9 0.1 1.4 1 0 0 1 1 1 1 UvrD/REP helicase N-terminal domain AAA_7 PF12775.7 ETO21916.1 - 0.0042 16.6 0.1 0.01 15.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region DUF2075 PF09848.9 ETO21916.1 - 0.0043 16.3 0.1 0.0071 15.6 0.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_11 PF13086.6 ETO21916.1 - 0.0083 15.9 0.3 0.32 10.7 0.1 2.3 2 0 0 2 2 2 1 AAA domain PhoH PF02562.16 ETO21916.1 - 0.024 14.1 1.1 0.077 12.4 1.1 1.8 1 1 0 1 1 1 0 PhoH-like protein AAA_14 PF13173.6 ETO21916.1 - 0.033 14.2 0.2 1.3 9.1 0.1 3.4 3 2 0 3 3 2 0 AAA domain TrwB_AAD_bind PF10412.9 ETO21916.1 - 0.034 13.1 0.1 0.058 12.3 0.1 1.3 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_16 PF13191.6 ETO21916.1 - 0.04 14.3 0.1 0.094 13.1 0.1 1.6 1 0 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO21916.1 - 0.042 14.3 0.0 0.1 13.1 0.0 1.7 1 0 0 1 1 1 0 ABC transporter ATPase PF06745.13 ETO21916.1 - 0.051 12.9 0.0 0.086 12.2 0.0 1.3 1 0 0 1 1 1 0 KaiC cobW PF02492.19 ETO21916.1 - 0.054 13.1 0.2 1.8 8.1 0.0 2.3 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CHCH PF06747.13 ETO21916.1 - 0.065 13.4 1.8 0.18 12.0 0.4 2.4 2 0 0 2 2 2 0 CHCH domain AAA_33 PF13671.6 ETO21916.1 - 0.073 13.2 0.1 0.4 10.8 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO21916.1 - 0.13 12.1 0.0 0.32 10.8 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF4611 PF15387.6 ETO21916.1 - 0.14 12.4 1.2 0.29 11.4 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Utp14 PF04615.13 ETO21916.1 - 0.16 10.5 0.5 0.25 9.9 0.5 1.1 1 0 0 1 1 1 0 Utp14 protein CENP-B_dimeris PF09026.10 ETO21916.1 - 2.6 8.5 8.1 12 6.3 8.1 2.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Myotub-related PF06602.14 ETO21917.1 - 5.7e-71 239.3 0.8 7.9e-71 238.8 0.8 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 ETO21917.1 - 0.0015 18.3 0.2 0.0084 15.9 0.1 2.1 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO21917.1 - 0.0033 17.0 0.0 0.0056 16.3 0.0 1.3 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Y_phosphatase3 PF13350.6 ETO21917.1 - 0.042 13.8 0.0 0.077 12.9 0.0 1.4 1 0 0 1 1 1 0 Tyrosine phosphatase family GDI PF00996.18 ETO21918.1 - 8.6e-29 100.3 0.8 9.7e-29 100.1 0.8 1.0 1 0 0 1 1 1 1 GDP dissociation inhibitor RRM_1 PF00076.22 ETO21919.1 - 4e-17 61.8 0.0 7.4e-17 60.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO21919.1 - 0.00041 20.3 0.0 0.00074 19.5 0.0 1.5 1 0 0 1 1 1 1 Nup53/35/40-type RNA recognition motif muHD PF10291.9 ETO21920.1 - 0.00014 21.4 0.0 0.00028 20.4 0.0 1.5 1 0 0 1 1 1 1 Muniscin C-terminal mu homology domain Coat_X PF07552.11 ETO21921.1 - 0.0082 16.0 2.1 0.034 14.0 0.3 2.7 3 0 0 3 3 3 1 Spore Coat Protein X and V domain SCAB-Ig PF16709.5 ETO21921.1 - 0.012 15.7 0.0 0.025 14.6 0.0 1.6 1 0 0 1 1 1 0 Ig domain of plant-specific actin-binding protein Endostatin PF06482.11 ETO21921.1 - 0.038 13.4 0.0 0.085 12.3 0.0 1.5 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin SCAB-PH PF17684.1 ETO21921.1 - 0.04 14.1 0.0 0.085 13.1 0.0 1.6 1 0 0 1 1 1 0 PH domain of plant-specific actin-binding protein GDA1_CD39 PF01150.17 ETO21922.1 - 2.2e-33 115.6 0.9 3.7e-30 104.9 0.2 2.5 2 1 0 2 2 2 2 GDA1/CD39 (nucleoside phosphatase) family FBP_C PF16571.5 ETO21923.1 - 0.015 14.8 0.3 0.035 13.6 0.2 1.7 1 1 0 1 1 1 0 FBP C-terminal treble-clef zinc-finger TF_Zn_Ribbon PF08271.12 ETO21923.1 - 0.044 13.3 0.3 0.091 12.3 0.3 1.5 1 0 0 1 1 1 0 TFIIB zinc-binding FOXP-CC PF16159.5 ETO21923.1 - 0.35 11.5 2.3 0.3 11.7 0.4 1.8 2 0 0 2 2 2 0 FOXP coiled-coil domain GTP_EFTU PF00009.27 ETO21924.1 - 0.0013 18.3 0.0 0.0014 18.2 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Ribosomal_L13 PF00572.18 ETO21925.1 - 0.026 14.8 1.5 5.3 7.3 0.7 2.3 2 0 0 2 2 2 0 Ribosomal protein L13 CDC45 PF02724.14 ETO21925.1 - 0.055 11.8 0.6 0.084 11.2 0.6 1.2 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO21926.1 - 2.3e-130 420.6 38.8 6.3e-10 39.5 0.2 14.5 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21926.1 - 1.2e-36 124.8 6.5 0.00075 19.7 0.0 12.2 1 1 12 13 13 13 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO21926.1 - 7.6e-24 84.3 8.9 0.0053 15.8 0.0 12.7 1 1 13 14 14 14 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO21926.1 - 3e-17 62.9 0.1 7e-05 22.3 0.0 6.3 3 3 5 8 8 8 5 WD40-like domain Cytochrom_D1 PF02239.16 ETO21926.1 - 1.8e-11 43.2 10.1 0.012 14.2 0.1 6.3 1 1 7 8 8 8 5 Cytochrome D1 heme domain NACHT PF05729.12 ETO21926.1 - 2.4e-09 37.3 0.0 5.8e-09 36.1 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO21926.1 - 3.6e-06 26.5 3.8 5.5e-05 22.7 3.0 2.2 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Proteasome_A_N PF10584.9 ETO21926.1 - 3.6e-05 23.3 8.5 4.8 7.0 0.0 7.4 8 0 0 8 8 8 1 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO21926.1 - 0.0003 20.9 24.1 5.2 7.2 0.3 9.0 1 1 7 9 9 9 1 Family of unknown function (DUF5570) Pentapeptide_4 PF13599.6 ETO21926.1 - 0.00056 20.0 0.1 0.0018 18.4 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO21926.1 - 0.0013 19.0 0.0 0.004 17.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain Torsin PF06309.11 ETO21926.1 - 0.0022 18.1 1.4 0.016 15.3 0.1 2.5 2 0 0 2 2 2 1 Torsin Gmad1 PF10647.9 ETO21926.1 - 0.0024 17.7 4.4 1.7 8.4 0.0 3.9 2 2 1 3 3 3 2 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 ETO21926.1 - 0.0039 17.1 12.6 21 5.2 0.1 7.6 8 0 0 8 8 7 0 WD40-like Beta Propeller Repeat AAA_18 PF13238.6 ETO21926.1 - 0.008 16.7 0.0 0.029 14.9 0.0 2.0 1 0 0 1 1 1 1 AAA domain Pentapeptide_3 PF13576.6 ETO21926.1 - 0.013 15.6 0.2 0.036 14.2 0.2 1.8 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) TsaE PF02367.17 ETO21926.1 - 0.024 14.6 0.0 0.32 11.0 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE DUF2527 PF10736.9 ETO21926.1 - 0.059 13.2 0.0 2.6 7.9 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2627) DUF3931 PF13082.6 ETO21926.1 - 0.14 12.3 0.1 0.6 10.3 0.1 2.1 2 0 0 2 2 1 0 Protein of unknown function (DUF3931) AAA PF00004.29 ETO21926.1 - 0.15 12.5 0.0 0.39 11.1 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NAD_binding_1 PF00175.21 ETO21927.1 - 0.026 15.2 0.0 1.9 9.2 0.0 2.3 1 1 0 1 1 1 0 Oxidoreductase NAD-binding domain LYRIC PF15686.5 ETO21929.1 - 0.1 12.1 2.0 0.58 9.7 0.0 1.9 2 0 0 2 2 2 0 Lysine-rich CEACAM1 co-isolated protein family DUF4710 PF15828.5 ETO21929.1 - 7.8 6.7 12.9 0.88 9.7 4.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) WXG100 PF06013.12 ETO21931.1 - 0.13 12.5 2.4 0.1 12.8 0.8 1.6 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DUF3896 PF13035.6 ETO21931.1 - 0.15 12.2 1.9 1.2 9.4 0.6 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3896) CPSF_A PF03178.15 ETO21932.1 - 4.7e-34 118.1 0.9 6.7e-34 117.7 0.9 1.2 1 0 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 ETO21933.1 - 8.7e-36 123.6 0.7 1.3e-35 123.0 0.7 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term 7TM_GPCR_Srx PF10328.9 ETO21934.1 - 0.042 13.5 1.8 0.071 12.7 1.8 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DnaJ PF00226.31 ETO21936.1 - 0.019 15.1 0.2 0.062 13.4 0.0 2.0 2 0 0 2 2 2 0 DnaJ domain Rick_17kDa_Anti PF05433.15 ETO21936.1 - 0.057 13.3 9.8 0.45 10.4 3.9 2.4 2 0 0 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 ETO21936.1 - 0.081 12.9 11.0 0.19 11.8 4.9 2.4 2 0 0 2 2 2 0 Glycine zipper Ac76 PF05814.11 ETO21936.1 - 0.63 10.1 5.2 2.5 8.1 0.0 2.4 2 0 0 2 2 2 0 Orf76 (Ac76) Iron_permease PF04120.12 ETO21937.1 - 0.16 11.8 1.5 0.3 10.9 1.5 1.6 1 1 0 1 1 1 0 Low affinity iron permease Ctr PF04145.15 ETO21938.1 - 0.29 11.7 7.7 3.7 8.1 0.4 3.6 3 0 0 3 3 3 0 Ctr copper transporter family CPSF100_C PF13299.6 ETO21938.1 - 1.2 9.3 10.2 2 8.6 1.5 3.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Connexin PF00029.19 ETO21938.1 - 1.5 8.6 9.2 16 5.1 2.4 3.2 3 0 0 3 3 3 0 Connexin EVI2A PF05399.11 ETO21938.1 - 2 8.0 22.1 2.7 7.5 7.0 3.6 3 0 0 3 3 3 0 Ectropic viral integration site 2A protein (EVI2A) Zip PF02535.22 ETO21938.1 - 2.8 7.1 9.6 1.4 8.0 0.1 2.7 3 0 0 3 3 3 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO21938.1 - 2.8 9.0 23.5 2 9.4 2.0 4.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) HlyIII PF03006.20 ETO21940.1 - 1.9e-19 70.3 21.4 1.9e-19 70.3 21.4 1.9 1 1 1 2 2 2 1 Haemolysin-III related Peptidase_U4 PF03419.13 ETO21940.1 - 8.2 5.6 23.6 0.15 11.3 15.0 1.9 1 1 0 2 2 2 0 Sporulation factor SpoIIGA DUF3487 PF11990.8 ETO21940.1 - 9.8 6.1 10.0 1.9 8.4 2.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3487) SAM_KSR1 PF13543.6 ETO21942.1 - 0.3 11.2 2.2 0.22 11.7 0.2 1.7 2 0 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 B56 PF01603.20 ETO21943.1 - 4e-05 22.8 0.1 6.3e-05 22.1 0.1 1.3 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) CPSF100_C PF13299.6 ETO21944.1 - 1.7e-06 28.3 0.9 2.9e-06 27.6 0.9 1.3 1 1 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal Menin PF05053.13 ETO21944.1 - 0.055 11.8 6.4 0.053 11.9 6.4 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO21944.1 - 0.54 10.8 23.1 1.2 9.7 18.7 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain Apc15p PF05841.11 ETO21944.1 - 1.4 9.8 13.1 0.4 11.5 10.6 1.4 2 0 0 2 2 2 0 Apc15p protein Orf78 PF06024.12 ETO21944.1 - 2.1 8.7 7.7 4.2 7.7 7.7 1.6 1 0 0 1 1 1 0 Orf78 (ac78) NST1 PF13945.6 ETO21944.1 - 3.1 7.9 14.8 1 9.4 12.6 1.4 2 0 0 2 2 2 0 Salt tolerance down-regulator Peptidase_M15 PF01427.17 ETO21944.1 - 4.8 6.9 6.3 1.2 8.8 0.1 2.1 1 1 1 2 2 2 0 D-ala-D-ala dipeptidase WD40 PF00400.32 ETO21946.1 - 1.1e-31 108.4 33.3 1.1e-05 26.1 2.8 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21946.1 - 2.3e-09 37.4 4.8 0.5 10.7 0.0 5.5 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO21946.1 - 4e-08 32.4 12.2 0.0021 16.8 0.3 5.3 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO21946.1 - 0.00014 21.3 4.3 0.15 11.4 0.1 4.4 2 2 2 5 5 5 2 WD40-like domain DUF4221 PF13970.6 ETO21946.1 - 0.63 9.5 5.3 0.51 9.8 0.6 2.7 1 1 3 4 4 4 0 Domain of unknown function (DUF4221) TPR_1 PF00515.28 ETO21947.1 - 4.7e-15 54.7 0.9 1.2e-06 28.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO21947.1 - 5.9e-13 47.9 1.0 6.6e-05 22.7 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO21947.1 - 2.7e-10 39.6 2.7 0.0021 18.1 0.1 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO21947.1 - 7.2e-09 35.2 3.4 0.016 14.9 0.1 3.6 2 1 1 3 3 3 3 TPR repeat TPR_12 PF13424.6 ETO21947.1 - 3.7e-08 33.5 8.6 2.3e-06 27.8 0.8 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat Prefoldin_2 PF01920.20 ETO21947.1 - 7.4e-07 29.1 0.5 7.4e-07 29.1 0.5 2.9 2 1 0 3 3 3 1 Prefoldin subunit TPR_9 PF13371.6 ETO21947.1 - 1.6e-06 28.1 0.1 3.6e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO21947.1 - 7.5e-06 26.3 4.1 0.055 14.1 0.3 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO21947.1 - 9.2e-06 25.3 4.0 0.11 12.6 0.1 3.9 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO21947.1 - 6e-05 23.6 0.6 0.34 11.6 0.0 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO21947.1 - 0.00031 21.3 1.4 0.16 12.9 0.1 3.6 2 1 2 4 4 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO21947.1 - 0.00043 20.7 5.7 0.02 15.4 3.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO21947.1 - 0.00077 19.7 1.5 0.024 15.0 0.1 2.9 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO21947.1 - 0.0029 17.9 4.1 0.021 15.1 2.1 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO21947.1 - 0.0051 16.1 3.8 0.081 12.1 3.5 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO21947.1 - 0.0059 16.8 3.2 0.013 15.7 3.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO21947.1 - 0.064 12.7 0.1 4.8 6.7 0.1 2.5 2 0 0 2 2 2 0 SHNi-TPR Fis1_TPR_C PF14853.6 ETO21947.1 - 0.12 12.5 3.4 0.59 10.2 1.1 2.6 1 1 1 2 2 2 0 Fis1 C-terminal tetratricopeptide repeat UbiA PF01040.18 ETO21948.1 - 2e-13 50.2 12.2 7e-13 48.4 12.2 1.8 1 1 0 1 1 1 1 UbiA prenyltransferase family DUF4133 PF13571.6 ETO21948.1 - 0.87 10.0 6.3 13 6.2 3.9 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4133) Vps35 PF03635.17 ETO21949.1 - 2.6e-15 56.0 2.0 2.7e-15 55.9 2.0 1.1 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 SLATT_5 PF18160.1 ETO21950.1 - 0.19 11.0 0.9 0.26 10.6 0.9 1.3 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 WD40 PF00400.32 ETO21952.1 - 1.5e-58 193.4 14.7 3.2e-11 43.6 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO21952.1 - 4.3e-27 94.2 1.0 9.3e-06 25.9 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO21952.1 - 2.2e-13 50.6 0.3 1.1e-07 31.9 0.1 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO21952.1 - 3.8e-13 49.1 0.4 0.27 10.2 0.1 6.4 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO21952.1 - 5.9e-12 45.5 0.1 0.0022 17.3 0.0 3.3 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO21952.1 - 6e-09 35.1 1.0 2.4 6.7 0.0 6.0 2 1 4 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO21952.1 - 1.9e-08 33.2 0.1 0.0016 17.0 0.0 2.8 2 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO21952.1 - 6e-07 29.2 9.3 1.7 8.7 0.0 6.8 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO21952.1 - 2.1e-05 24.6 2.2 15 5.7 0.1 5.5 2 1 4 6 6 6 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO21952.1 - 6e-05 22.0 5.7 3.1 6.4 1.4 4.8 1 1 3 4 4 4 2 Nup133 N terminal like Str_synth PF03088.16 ETO21952.1 - 0.00035 20.6 0.0 7.8 6.7 0.0 4.0 2 2 2 4 4 4 1 Strictosidine synthase IKI3 PF04762.12 ETO21952.1 - 0.00052 18.2 1.1 0.75 7.7 0.1 3.0 1 1 2 3 3 3 2 IKI3 family Me-amine-dh_H PF06433.11 ETO21952.1 - 0.0011 17.9 0.0 0.46 9.3 0.0 2.6 2 1 0 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) VID27 PF08553.10 ETO21952.1 - 0.0072 15.4 0.2 9.1 5.2 0.0 3.1 2 2 2 4 4 4 1 VID27 C-terminal WD40-like domain Big_7 PF17957.1 ETO21952.1 - 0.019 15.7 0.5 2.1 9.2 0.1 3.4 2 1 1 3 3 3 0 Bacterial Ig domain RAB3GAP2_N PF14655.6 ETO21952.1 - 0.065 12.5 0.1 4.7 6.4 0.0 2.6 1 1 2 3 3 3 0 Rab3 GTPase-activating protein regulatory subunit N-terminus Utp8 PF10395.9 ETO21952.1 - 0.092 11.2 0.0 1.5 7.2 0.0 2.1 1 1 1 2 2 2 0 Utp8 family Proteasome_A_N PF10584.9 ETO21952.1 - 0.69 9.6 5.2 58 3.5 0.0 4.9 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF412 PF04217.13 ETO21953.1 - 0.0043 16.9 0.2 0.011 15.7 0.2 1.6 1 0 0 1 1 1 1 Protein of unknown function, DUF412 Synapsin_C PF02750.14 ETO21954.1 - 4e-17 62.4 0.2 5.3e-17 62.0 0.2 1.2 1 0 0 1 1 1 1 Synapsin, ATP binding domain MetallophosC PF16370.5 ETO21954.1 - 0.027 14.7 0.2 0.045 14.0 0.2 1.4 1 0 0 1 1 1 0 C terminal of Calcineurin-like phosphoesterase RhoGEF PF00621.20 ETO21955.1 - 4.1e-40 138.0 3.1 4.1e-40 138.0 3.1 2.1 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 ETO21955.1 - 1.4e-13 50.7 8.9 3.2e-13 49.6 8.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger Menin PF05053.13 ETO21955.1 - 1.5 7.1 8.7 3.9 5.7 8.7 1.6 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO21955.1 - 5.5 7.6 24.1 0.66 10.6 18.3 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain FYVE_2 PF02318.16 ETO21955.1 - 6.1 7.1 20.3 0.052 13.8 6.9 2.6 2 0 0 2 2 2 0 FYVE-type zinc finger Peptidase_M1 PF01433.20 ETO21957.1 - 1.3e-48 165.5 0.3 1.8e-48 165.0 0.3 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain Peptidase_M1_N PF17900.1 ETO21957.1 - 2e-26 93.4 0.1 2.8e-26 92.9 0.1 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain WLM PF08325.10 ETO21957.1 - 0.28 11.2 0.7 0.37 10.8 0.0 1.4 2 0 0 2 2 2 0 WLM domain Peptidase_M1 PF01433.20 ETO21958.1 - 2.1e-26 92.9 0.1 2.4e-26 92.6 0.1 1.1 1 0 0 1 1 1 1 Peptidase family M1 domain DivIC PF04977.15 ETO21959.1 - 0.016 15.0 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 Septum formation initiator EF-G-binding_N PF07299.11 ETO21959.1 - 0.037 14.5 0.6 0.092 13.3 0.1 1.8 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal GAS PF13851.6 ETO21959.1 - 0.044 13.1 2.4 0.084 12.2 2.4 1.4 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding TSC22 PF01166.18 ETO21959.1 - 0.05 13.9 2.0 0.17 12.3 1.1 2.3 2 1 1 3 3 3 0 TSC-22/dip/bun family Fez1 PF06818.15 ETO21959.1 - 0.06 13.8 0.8 0.06 13.8 0.8 1.5 2 0 0 2 2 2 0 Fez1 Tudor-knot PF11717.8 ETO21960.1 - 0.0052 16.6 0.1 0.021 14.7 0.1 2.0 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain FAM176 PF14851.6 ETO21960.1 - 0.43 10.2 2.7 0.26 10.9 0.2 2.0 2 0 0 2 2 2 0 FAM176 family Agenet PF05641.12 ETO21960.1 - 0.45 11.0 1.7 3.4 8.2 0.0 2.9 3 0 0 3 3 3 0 Agenet domain DUF4611 PF15387.6 ETO21960.1 - 0.64 10.3 8.8 2.2 8.6 8.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) CENP-B_dimeris PF09026.10 ETO21960.1 - 8.8 6.8 19.0 7.3 7.0 15.6 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF2222 PF09984.9 ETO21962.1 - 6.1 6.7 10.0 2.9 7.8 6.5 1.9 1 1 1 2 2 2 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) RRM_1 PF00076.22 ETO21963.1 - 7.5e-43 144.2 7.8 8.1e-14 51.2 0.3 7.4 7 0 0 7 7 7 6 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO21963.1 - 3.4e-06 27.1 0.8 0.025 14.7 0.1 5.4 6 0 0 6 6 6 1 RNA recognition motif Limkain-b1 PF11608.8 ETO21963.1 - 0.0022 18.0 3.5 1.8 8.7 0.0 4.2 4 1 0 4 4 4 2 Limkain b1 KH_1 PF00013.29 ETO21963.1 - 0.012 15.5 0.0 0.38 10.6 0.0 3.1 2 0 0 2 2 2 0 KH domain ASL_C PF08328.11 ETO21963.1 - 0.69 10.0 7.8 3.2 7.9 7.8 2.2 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal TLD PF07534.16 ETO21964.1 - 7.6e-32 110.4 0.5 1.6e-31 109.4 0.5 1.6 1 0 0 1 1 1 1 TLD Izumo-Ig PF16706.5 ETO21964.1 - 0.11 12.6 0.1 0.3 11.2 0.1 1.8 1 1 0 1 1 1 0 Izumo-like Immunoglobulin domain FH2 PF02181.23 ETO21965.1 - 0.023 13.8 0.0 0.027 13.6 0.0 1.2 1 0 0 1 1 1 0 Formin Homology 2 Domain Solute_trans_a PF03619.16 ETO21966.1 - 2.2e-64 217.5 15.3 4.1e-64 216.7 15.3 1.4 1 1 0 1 1 1 1 Organic solute transporter Ostalpha O-antigen_lig PF13425.6 ETO21967.1 - 0.0066 15.3 7.7 0.062 12.1 7.3 2.0 1 1 1 2 2 2 1 O-antigen ligase like membrane protein RGS PF00615.19 ETO21967.1 - 0.038 14.3 0.4 0.066 13.5 0.4 1.4 1 0 0 1 1 1 0 Regulator of G protein signaling domain MgtE PF01769.16 ETO21967.1 - 0.3 11.5 3.8 0.71 10.3 3.8 1.6 1 1 0 1 1 1 0 Divalent cation transporter MtN3_slv PF03083.16 ETO21967.1 - 0.31 11.1 6.5 4.1 7.5 0.1 2.5 2 0 0 2 2 2 0 Sugar efflux transporter for intercellular exchange GWT1 PF06423.12 ETO21967.1 - 0.77 9.9 4.6 1.2 9.3 4.2 1.8 1 1 0 1 1 1 0 GWT1 PCI PF01399.27 ETO21968.1 - 0.036 14.6 0.7 0.1 13.1 0.3 2.0 2 1 0 2 2 2 0 PCI domain Pkinase PF00069.25 ETO21969.1 - 5.8e-63 212.7 0.2 5.4e-62 209.6 0.2 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21969.1 - 2e-28 99.4 3.2 8.6e-22 77.7 0.9 2.8 1 1 1 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO21969.1 - 1.4e-07 30.8 1.8 2.8e-07 29.8 1.8 1.5 1 1 0 1 1 1 1 Haspin like kinase domain APH PF01636.23 ETO21969.1 - 0.0025 17.8 0.5 0.011 15.7 0.1 2.1 2 1 1 3 3 3 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO21969.1 - 0.0058 16.3 1.7 0.01 15.5 0.1 2.1 1 1 1 2 2 2 1 RIO1 family Kdo PF06293.14 ETO21969.1 - 0.0077 15.6 0.7 0.016 14.6 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ETO21969.1 - 0.0086 15.1 0.2 0.071 12.1 0.0 2.2 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase BBIP10 PF14777.6 ETO21969.1 - 0.079 12.5 1.3 0.18 11.4 1.3 1.6 1 0 0 1 1 1 0 Cilia BBSome complex subunit 10 LETM1 PF07766.13 ETO21970.1 - 1.3e-44 152.5 4.3 1.7e-44 152.2 4.3 1.1 1 0 0 1 1 1 1 LETM1-like protein MmgE_PrpD PF03972.14 ETO21972.1 - 7.8e-34 117.0 0.1 3.6e-33 114.8 0.1 1.9 1 1 0 1 1 1 1 MmgE/PrpD family DUF2154 PF09922.9 ETO21973.1 - 0.011 15.6 0.1 0.027 14.4 0.1 1.6 1 0 0 1 1 1 0 Cell wall-active antibiotics response 4TMS YvqF Pkinase PF00069.25 ETO21974.1 - 1.3e-10 41.1 0.2 1.7e-10 40.8 0.2 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO21974.1 - 2e-05 24.0 0.2 2.7e-05 23.6 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF5396 PF17374.2 ETO21974.1 - 0.036 11.9 1.6 0.042 11.7 1.6 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5396) ALMT PF11744.8 ETO21974.1 - 2.6 6.8 6.5 3.4 6.4 6.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Tubulin PF00091.25 ETO21975.1 - 3.5e-30 105.7 0.0 4.8e-30 105.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO21975.1 - 0.034 13.4 0.8 0.1 11.8 0.3 1.9 2 1 0 2 2 2 0 Tubulin like Tubulin_C PF03953.17 ETO21976.1 - 3.1e-05 24.1 0.0 5.8e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF2633 PF11119.8 ETO21976.1 - 0.04 13.8 1.0 0.096 12.6 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2633) AT_hook PF02178.19 ETO21977.1 - 4.1 7.6 21.4 8.3 6.7 5.3 2.7 2 0 0 2 2 2 0 AT hook motif Mito_fiss_reg PF05308.11 ETO21978.1 - 0.0022 18.1 9.0 0.0022 18.1 9.0 3.0 3 0 0 3 3 3 1 Mitochondrial fission regulator Rpn3_C PF08375.11 ETO21978.1 - 0.15 12.5 6.2 0.69 10.4 0.1 2.5 2 0 0 2 2 2 0 Proteasome regulatory subunit C-terminal PRIMA1 PF16101.5 ETO21978.1 - 0.44 10.6 12.3 1.4 9.0 12.3 1.9 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 Spt20 PF12090.8 ETO21978.1 - 1.2 8.6 27.9 0.083 12.5 16.5 2.3 2 0 0 2 2 2 0 Spt20 family CAP_N PF01213.19 ETO21978.1 - 7.5 5.9 15.9 1.5 8.2 8.9 2.4 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Chalcone_2 PF16035.5 ETO21980.1 - 0.0095 15.7 0.2 0.011 15.5 0.2 1.1 1 0 0 1 1 1 1 Chalcone isomerase like DUF1694 PF07997.11 ETO21980.1 - 0.088 12.9 1.4 0.13 12.3 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1694) RPEL PF02755.15 ETO21981.1 - 0.062 13.0 5.2 0.53 10.1 0.1 3.6 3 0 0 3 3 3 0 RPEL repeat NOP5NT PF08156.13 ETO21982.1 - 4.2e-15 55.9 0.5 7.5e-15 55.1 0.5 1.4 1 0 0 1 1 1 1 NOP5NT (NUC127) domain Nop PF01798.18 ETO21982.1 - 1.8e-14 53.8 0.0 3.1e-14 53.0 0.0 1.4 1 0 0 1 1 1 1 snoRNA binding domain, fibrillarin Tis11B_N PF04553.12 ETO21985.1 - 0.55 10.8 6.5 3.9 8.1 0.1 2.6 1 1 1 2 2 2 0 Tis11B like protein, N terminus Med19 PF10278.9 ETO21986.1 - 0.59 10.0 10.6 0.93 9.4 10.6 1.3 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Kinesin PF00225.23 ETO21987.1 - 2.6e-37 128.5 2.0 1.8e-36 125.8 0.0 2.0 2 0 0 2 2 2 1 Kinesin motor domain PBP_dimer PF03717.15 ETO21987.1 - 0.0081 16.5 5.3 0.012 15.9 5.3 1.2 1 0 0 1 1 1 1 Penicillin-binding Protein dimerisation domain DUF1192 PF06698.11 ETO21987.1 - 0.01 15.9 5.2 0.28 11.3 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Sec2p PF06428.11 ETO21987.1 - 0.015 15.2 9.1 0.16 11.9 1.2 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p ABC_tran_CTD PF16326.5 ETO21987.1 - 0.017 15.4 11.2 2.1 8.6 11.2 2.4 1 1 0 1 1 1 0 ABC transporter C-terminal domain PCRF PF03462.18 ETO21987.1 - 0.046 13.6 6.5 0.069 13.0 6.5 1.2 1 0 0 1 1 1 0 PCRF domain SlyX PF04102.12 ETO21987.1 - 0.16 12.6 7.4 4 8.1 0.6 2.4 2 0 0 2 2 2 0 SlyX CLZ PF16526.5 ETO21987.1 - 0.18 12.2 9.3 0.67 10.4 0.6 2.5 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Tropomyosin_1 PF12718.7 ETO21987.1 - 0.24 11.5 12.9 0.45 10.7 12.9 1.4 1 0 0 1 1 1 0 Tropomyosin like MPS2 PF17060.5 ETO21987.1 - 0.29 10.4 7.5 0.38 10.0 7.5 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 DUF4200 PF13863.6 ETO21987.1 - 0.31 11.4 15.6 0.59 10.5 12.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Med9 PF07544.13 ETO21987.1 - 0.91 9.7 11.4 3.5 7.8 11.4 1.9 1 1 0 1 1 1 0 RNA polymerase II transcription mediator complex subunit 9 Prefoldin_2 PF01920.20 ETO21987.1 - 1.6 8.7 16.2 2 8.4 2.5 2.3 2 0 0 2 2 2 0 Prefoldin subunit RP-C_C PF11800.8 ETO21987.1 - 1.7 8.7 7.1 5.8 7.0 7.1 1.9 1 1 0 1 1 1 0 Replication protein C C-terminal region JAKMIP_CC3 PF16034.5 ETO21987.1 - 2.4 8.1 12.8 7 6.5 12.8 1.7 1 1 0 1 1 1 0 JAKMIP CC3 domain DUF4407 PF14362.6 ETO21987.1 - 2.8 7.2 8.9 12 5.1 9.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) YvrJ PF12841.7 ETO21987.1 - 3.9 7.1 5.2 21 4.8 0.2 2.5 2 0 0 2 2 2 0 YvrJ protein family PspB PF06667.12 ETO21987.1 - 5 7.3 6.8 6.4 6.9 0.3 2.9 3 0 0 3 3 3 0 Phage shock protein B BST2 PF16716.5 ETO21987.1 - 7.3 7.2 15.7 6.4 7.4 1.8 2.3 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Drf_FH3 PF06367.16 ETO21988.1 - 2.5e-06 27.2 1.3 7.8e-06 25.6 0.3 2.3 2 0 0 2 2 2 1 Diaphanous FH3 Domain Drf_GBD PF06371.13 ETO21988.1 - 0.19 11.3 3.2 0.15 11.7 0.5 2.2 2 1 0 2 2 2 0 Diaphanous GTPase-binding Domain KinB_sensor PF16767.5 ETO21989.1 - 0.037 14.5 0.3 0.15 12.5 0.1 2.0 2 1 0 2 2 2 0 Sensor domain of alginate biosynthesis sensor protein KinB RPN5_C PF18098.1 ETO21990.1 - 7.2e-16 58.0 2.1 6e-15 55.0 3.2 2.0 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN5 C-terminal domain PCI PF01399.27 ETO21990.1 - 2.8e-07 31.0 1.1 7.4e-07 29.6 0.1 2.2 2 1 1 3 3 3 1 PCI domain HTH_17 PF12728.7 ETO21990.1 - 0.0053 16.9 0.0 0.01 16.0 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix domain DUF3535 PF12054.8 ETO21990.1 - 0.11 11.8 0.1 0.13 11.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3535) eIF3m_C_helix PF18005.1 ETO21990.1 - 2.7 7.7 5.8 14 5.4 0.2 2.9 3 0 0 3 3 3 0 eIF3 subunit M, C-terminal helix HP0268 PF18618.1 ETO21991.1 - 0.16 12.4 2.9 0.5 10.8 0.1 2.4 2 1 0 2 2 2 0 HP0268 2OG-FeII_Oxy_3 PF13640.6 ETO21992.1 - 5.9e-17 62.4 0.0 1.8e-16 60.8 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ETO21992.1 - 0.00018 22.0 0.0 0.0009 19.7 0.0 2.1 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 ETO21992.1 - 0.00022 21.8 0.1 0.00058 20.5 0.0 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily MAP70 PF07058.11 ETO21992.1 - 0.12 11.1 0.0 3.6 6.2 0.0 2.0 2 0 0 2 2 2 0 Microtubule-associated protein 70 BUD22 PF09073.10 ETO21993.1 - 0.0032 16.9 17.1 0.0039 16.6 17.1 1.1 1 0 0 1 1 1 1 BUD22 PPL5 PF18168.1 ETO21993.1 - 0.097 11.9 8.0 0.13 11.5 8.0 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF4746 PF15928.5 ETO21993.1 - 0.38 10.1 14.4 0.45 9.9 14.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_3_Rpc31 PF11705.8 ETO21993.1 - 0.6 10.3 19.9 0.82 9.9 19.9 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 V_ATPase_I PF01496.19 ETO21993.1 - 1.7 6.5 11.4 2 6.2 11.4 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family ALMT PF11744.8 ETO21993.1 - 2.1 7.1 13.4 2.6 6.8 13.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Erythro_esteras PF05139.14 ETO21993.1 - 3.5 7.3 8.0 4.8 6.9 8.0 1.1 1 0 0 1 1 1 0 Erythromycin esterase Arm PF00514.23 ETO21994.1 - 6.7e-05 22.8 1.2 0.023 14.7 0.0 3.9 6 0 0 6 6 6 1 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO21994.1 - 0.0032 17.9 0.0 3.7 8.2 0.0 2.9 2 0 0 2 2 2 2 HEAT-like repeat Ric8 PF10165.9 ETO21994.1 - 0.015 14.4 0.1 0.053 12.6 0.0 1.7 1 1 1 2 2 2 0 Guanine nucleotide exchange factor synembryn Anti-adapt_IraP PF10796.9 ETO21994.1 - 0.062 13.9 0.0 0.18 12.4 0.0 1.8 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein TetR_C_16 PF17920.1 ETO21994.1 - 0.15 12.3 0.0 9.1 6.6 0.0 2.4 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Na_Ca_ex PF01699.24 ETO21996.1 - 9.3e-24 84.1 4.5 1.5e-23 83.5 4.5 1.2 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Ssu72 PF04722.13 ETO21996.1 - 0.034 13.7 0.3 0.051 13.1 0.3 1.2 1 0 0 1 1 1 0 Ssu72-like protein DUF3915 PF13054.6 ETO21996.1 - 0.14 12.2 0.0 0.29 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) PCM1_C PF15717.5 ETO21996.1 - 0.87 8.2 7.1 1.2 7.8 7.1 1.1 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus DUF2951 PF11166.8 ETO21997.1 - 0.046 13.9 4.1 0.11 12.7 4.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF3682 PF12446.8 ETO21997.1 - 0.18 12.3 0.2 0.25 11.8 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) fn3 PF00041.21 ETO22000.1 - 0.00025 21.3 0.0 0.00082 19.7 0.0 1.9 1 1 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ETO22000.1 - 0.0035 17.9 0.0 0.0061 17.1 0.0 1.7 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 ETO22000.1 - 0.0047 17.2 2.3 0.005 17.1 0.2 2.2 3 0 0 3 3 3 1 Interferon-alpha/beta receptor, fibronectin type III SKA2 PF16740.5 ETO22000.1 - 0.025 14.4 7.6 0.13 12.0 3.4 2.3 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 DUF3450 PF11932.8 ETO22000.1 - 0.9 8.8 6.2 0.17 11.2 2.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) ATG13 PF10033.9 ETO22001.1 - 4.5e-06 26.5 2.1 3.2e-05 23.7 0.2 2.3 1 1 1 2 2 2 1 Autophagy-related protein 13 YL1 PF05764.13 ETO22001.1 - 0.0019 18.4 9.0 0.0031 17.7 9.0 1.4 1 0 0 1 1 1 1 YL1 nuclear protein DNA_pol_phi PF04931.13 ETO22001.1 - 0.033 12.3 7.4 0.049 11.7 7.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF5528 PF17666.1 ETO22001.1 - 0.035 14.1 0.0 0.091 12.7 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5528) LHH PF14411.6 ETO22001.1 - 0.036 14.2 0.6 3.3 7.9 0.1 2.7 2 0 0 2 2 2 0 A nuclease of the HNH/ENDO VII superfamily with conserved LHH BSP_II PF05432.11 ETO22001.1 - 0.041 13.6 14.3 0.061 13.0 14.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4666 PF15697.5 ETO22001.1 - 0.062 14.0 1.4 0.14 12.8 1.4 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) SDA1 PF05285.12 ETO22001.1 - 0.14 11.6 13.6 0.2 11.0 13.6 1.3 1 0 0 1 1 1 0 SDA1 PI3K_1B_p101 PF10486.9 ETO22001.1 - 0.14 9.9 6.5 0.18 9.6 6.5 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 ETO22001.1 - 0.25 9.6 9.9 0.33 9.2 9.9 1.1 1 0 0 1 1 1 0 CDC45-like protein RPN2_C PF18004.1 ETO22001.1 - 0.26 11.2 8.8 0.13 12.2 6.7 1.6 2 0 0 2 2 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain CobT PF06213.12 ETO22001.1 - 0.4 10.0 12.0 0.51 9.7 12.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2052 PF09747.9 ETO22001.1 - 0.56 10.3 15.5 0.038 14.1 10.8 1.6 2 0 0 2 2 1 0 Coiled-coil domain containing protein (DUF2052) DUF4637 PF15470.6 ETO22001.1 - 0.94 9.2 10.8 1.6 8.4 10.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Saw1 PF11561.8 ETO22001.1 - 1.5 8.3 4.4 3.3 7.2 4.4 1.7 1 0 0 1 1 1 0 Single strand annealing-weakened 1 TFIIF_alpha PF05793.12 ETO22001.1 - 1.7 7.2 16.8 2.4 6.6 16.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Paf1 PF03985.13 ETO22001.1 - 3 6.7 16.9 4.3 6.2 16.9 1.2 1 0 0 1 1 1 0 Paf1 CCSAP PF15748.5 ETO22001.1 - 4.6 7.3 12.2 7.2 6.7 12.2 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated RR_TM4-6 PF06459.12 ETO22001.1 - 4.6 7.0 12.9 8.6 6.1 12.9 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Spt5_N PF11942.8 ETO22001.1 - 5.7 8.0 18.4 18 6.4 18.4 1.8 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal DUF2457 PF10446.9 ETO22001.1 - 5.9 5.9 17.7 10 5.1 17.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pes-10 PF07149.11 ETO22001.1 - 7.6 5.5 13.7 11 5.0 13.7 1.1 1 0 0 1 1 1 0 Pes-10 RRN3 PF05327.11 ETO22002.1 - 0.01 14.4 0.1 0.01 14.4 0.1 1.8 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2627 PF11118.8 ETO22002.1 - 0.49 11.0 8.5 1.2 9.8 0.0 3.9 4 1 1 5 5 5 0 Protein of unknown function (DUF2627) SLX9 PF15341.6 ETO22002.1 - 1.6 9.1 17.8 9.7 6.6 17.5 2.0 2 0 0 2 2 2 0 Ribosome biogenesis protein SLX9 TFIIA PF03153.13 ETO22002.1 - 5.1 7.0 20.2 8.1 6.3 20.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DNA_pol_phi PF04931.13 ETO22002.1 - 6 4.8 18.9 13 3.7 18.9 1.5 1 0 0 1 1 1 0 DNA polymerase phi NB-ARC PF00931.22 ETO22003.1 - 0.0095 15.2 2.1 0.025 13.7 2.1 1.6 1 1 0 1 1 1 1 NB-ARC domain Cbl_N2 PF02761.14 ETO22003.1 - 0.018 15.8 0.7 0.051 14.3 0.7 1.7 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain G-alpha PF00503.20 ETO22004.1 - 1.4e-12 47.4 2.3 1.6e-12 47.3 2.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO22004.1 - 0.0082 16.7 1.1 0.015 15.8 0.0 1.8 1 1 1 2 2 2 1 ABC transporter AAA_29 PF13555.6 ETO22004.1 - 0.032 14.0 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain Arf PF00025.21 ETO22004.1 - 0.045 13.2 0.2 0.076 12.5 0.1 1.5 1 1 0 1 1 1 0 ADP-ribosylation factor family AAA_16 PF13191.6 ETO22004.1 - 0.057 13.8 0.0 0.071 13.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_28 PF13521.6 ETO22004.1 - 0.068 13.4 0.5 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ETO22004.1 - 0.2 11.5 2.2 0.2 11.4 0.0 1.8 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system SRPRB PF09439.10 ETO22004.1 - 0.26 10.7 0.1 0.26 10.7 0.1 2.0 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO22004.1 - 0.29 11.2 1.0 0.74 9.9 0.1 2.0 2 1 0 2 2 2 0 50S ribosome-binding GTPase Hydant_A_N PF05378.13 ETO22005.1 - 1.3e-28 100.0 0.0 2e-28 99.3 0.0 1.3 1 0 0 1 1 1 1 Hydantoinase/oxoprolinase N-terminal region zf-UBP PF02148.19 ETO22007.1 - 1.2e-10 41.6 2.5 2.7e-10 40.4 2.5 1.5 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 ETO22007.1 - 3.1e-08 33.4 2.2 8.2e-08 32.1 0.3 2.2 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase SRP-alpha_N PF04086.13 ETO22007.1 - 0.0096 15.9 8.0 0.014 15.4 8.0 1.1 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal zinc_ribbon_9 PF14369.6 ETO22007.1 - 0.01 16.1 1.1 0.045 14.0 0.2 2.2 2 0 0 2 2 2 0 zinc-ribbon Prophage_tail PF06605.11 ETO22007.1 - 0.024 13.9 0.9 0.031 13.5 0.9 1.1 1 0 0 1 1 1 0 Prophage endopeptidase tail eIF-3c_N PF05470.12 ETO22007.1 - 0.059 11.7 5.6 0.078 11.3 5.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus zf-UBP_var PF17807.1 ETO22007.1 - 0.063 13.1 0.3 0.12 12.1 0.3 1.4 1 0 0 1 1 1 0 Variant UBP zinc finger MRNIP PF15749.5 ETO22007.1 - 0.073 13.8 4.2 0.12 13.1 4.2 1.4 1 0 0 1 1 1 0 MRN-interacting protein CarD_CdnL_TRCF PF02559.16 ETO22007.1 - 0.08 13.7 0.0 0.15 12.8 0.0 1.5 1 1 0 1 1 1 0 CarD-like/TRCF domain Trypan_PARP PF05887.11 ETO22007.1 - 0.69 9.9 2.6 1 9.3 2.6 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) FH2 PF02181.23 ETO22008.1 - 5.1e-28 98.3 4.1 6.8e-28 97.8 3.9 1.3 1 1 0 1 1 1 1 Formin Homology 2 Domain Drf_FH3 PF06367.16 ETO22010.1 - 0.00016 21.3 9.8 0.0004 20.1 1.8 3.1 2 1 1 3 3 3 2 Diaphanous FH3 Domain Gti1_Pac2 PF09729.9 ETO22010.1 - 0.035 14.2 5.6 0.19 11.8 3.9 2.6 1 1 1 2 2 2 0 Gti1/Pac2 family DUF913 PF06025.12 ETO22010.1 - 1.5 7.7 9.4 0.19 10.7 3.1 2.4 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) RP-C_C PF11800.8 ETO22010.1 - 2.8 8.0 7.8 0.2 11.7 2.5 1.8 2 0 0 2 2 2 0 Replication protein C C-terminal region GCD14 PF08704.10 ETO22010.1 - 2.8 7.6 6.8 3.5 7.2 2.3 2.5 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit RNA_pol_Rpc4 PF05132.14 ETO22010.1 - 6.6 7.1 9.9 0.61 10.5 4.9 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 EpuA PF11772.8 ETO22012.1 - 0.039 13.6 1.8 0.083 12.6 1.8 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase subunit beta Lipase_GDSL_2 PF13472.6 ETO22013.1 - 6e-05 23.5 0.0 9.7e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family CUB PF00431.20 ETO22013.1 - 0.051 13.9 0.2 0.13 12.6 0.2 1.7 1 0 0 1 1 1 0 CUB domain IBR PF01485.21 ETO22014.1 - 4.3e-07 30.1 4.8 4.3e-07 30.1 4.8 6.5 3 2 3 6 6 6 1 IBR domain, a half RING-finger domain zf-C3HC4 PF00097.25 ETO22014.1 - 3.4e-05 23.6 5.2 3.4e-05 23.6 5.2 4.9 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO22014.1 - 0.00046 20.5 7.7 0.00046 20.5 7.7 5.5 4 1 1 5 5 5 2 Ring finger domain Prok-RING_4 PF14447.6 ETO22014.1 - 0.014 15.3 9.2 0.014 15.3 9.2 4.3 4 0 0 4 4 4 0 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ETO22014.1 - 0.017 15.4 5.7 0.017 15.4 5.7 4.6 4 1 0 4 4 4 0 RING-H2 zinc finger domain zf-RING_UBOX PF13445.6 ETO22014.1 - 0.021 14.9 1.4 0.021 14.9 1.4 4.9 4 1 0 4 4 4 0 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETO22014.1 - 0.076 13.2 0.7 0.076 13.2 0.7 6.1 6 0 0 6 6 6 0 zinc finger of C3HC4-type, RING CCDC-167 PF15188.6 ETO22015.1 - 1.1 9.7 0.0 1.1 9.7 0.0 3.7 3 1 0 3 3 3 0 Coiled-coil domain-containing protein 167 TEX19 PF15553.6 ETO22015.1 - 1.6 8.7 4.6 4.2 7.3 4.6 1.7 1 0 0 1 1 1 0 Testis-expressed protein 19 Hydrolase PF00702.26 ETO22016.1 - 9e-09 35.9 0.0 1e-08 35.7 0.0 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase AhpC-TSA PF00578.21 ETO22016.1 - 0.018 15.0 0.0 0.096 12.6 0.0 2.0 2 0 0 2 2 2 0 AhpC/TSA family MlaC PF05494.12 ETO22016.1 - 0.018 14.8 1.7 0.028 14.2 1.7 1.4 1 1 0 1 1 1 0 MlaC protein DUF2608 PF11019.8 ETO22016.1 - 0.023 14.2 0.9 0.023 14.2 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF2608) VPS13_mid_rpt PF16910.5 ETO22016.1 - 0.052 13.0 2.3 0.074 12.5 2.3 1.3 1 0 0 1 1 1 0 Repeating coiled region of VPS13 ATP-synt_D PF01813.17 ETO22016.1 - 0.062 13.1 2.3 0.09 12.6 1.5 1.6 1 1 0 1 1 1 0 ATP synthase subunit D Pox_Ag35 PF03286.14 ETO22016.1 - 0.15 11.8 6.5 0.1 12.4 4.6 1.6 1 1 1 2 2 2 0 Pox virus Ag35 surface protein Menin PF05053.13 ETO22016.1 - 0.23 9.8 5.7 0.22 9.8 5.7 1.1 1 0 0 1 1 1 0 Menin Hydrolase_3 PF08282.12 ETO22016.1 - 1.7 8.3 11.3 3.2 7.4 0.1 2.3 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF2229 PF09989.9 ETO22017.1 - 0.43 10.2 2.8 3.4 7.3 2.9 2.0 2 0 0 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) AAA_23 PF13476.6 ETO22017.1 - 0.8 10.2 8.8 1.1 9.7 8.2 1.6 1 1 0 1 1 1 0 AAA domain Peptidase_S77 PF03420.13 ETO22018.1 - 0.0087 15.7 0.5 0.017 14.8 0.5 1.4 1 0 0 1 1 1 1 Prohead core protein serine protease CPSF100_C PF13299.6 ETO22018.1 - 0.039 14.1 6.5 0.078 13.2 1.0 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Ctr PF04145.15 ETO22018.1 - 0.12 13.0 1.7 0.7 10.5 0.0 2.2 2 0 0 2 2 2 0 Ctr copper transporter family MGC-24 PF05283.11 ETO22018.1 - 0.17 12.3 10.5 0.63 10.5 0.1 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin BT1 PF03092.16 ETO22018.1 - 0.26 9.5 0.7 0.49 8.6 0.7 1.4 1 0 0 1 1 1 0 BT1 family Mucin PF01456.17 ETO22018.1 - 0.33 10.9 13.7 7.2 6.6 0.0 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein TraH_2 PF06871.11 ETO22018.1 - 5.6 6.5 6.3 0.37 10.4 0.4 1.9 2 0 0 2 2 2 0 TraH_2 PIEZO PF15917.5 ETO22018.1 - 7.2 6.0 10.6 0.7 9.3 5.5 1.9 2 0 0 2 2 2 0 Piezo UCH PF00443.29 ETO22019.1 - 5.2e-37 127.7 0.0 1.1e-36 126.7 0.0 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO22019.1 - 2.2e-21 76.8 0.2 9.6e-19 68.1 0.2 3.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase MRNIP PF15749.5 ETO22019.1 - 0.034 14.9 0.7 7.9 7.2 0.0 2.4 2 0 0 2 2 2 0 MRN-interacting protein AAA_23 PF13476.6 ETO22020.1 - 1.9e-16 61.2 13.6 1.9e-16 61.2 13.6 4.4 2 1 2 4 4 4 1 AAA domain SMC_N PF02463.19 ETO22020.1 - 2.9e-10 40.0 8.4 1.4e-09 37.8 8.4 2.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ETO22020.1 - 5.1e-06 26.4 29.8 5.1e-06 26.4 29.8 3.2 2 1 0 2 2 2 1 AAA ATPase domain AAA_29 PF13555.6 ETO22020.1 - 0.0043 16.8 0.0 0.0087 15.8 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_21 PF13304.6 ETO22020.1 - 0.04 13.7 0.2 0.04 13.7 0.2 2.8 3 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system MHC_II_beta PF00969.19 ETO22020.1 - 8.5 6.6 7.6 3.3 7.9 0.2 3.3 3 0 0 3 3 3 0 Class II histocompatibility antigen, beta domain DUF1284 PF06935.11 ETO22020.1 - 9.9 6.7 12.0 3.1 8.3 6.8 2.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1284) Cullin PF00888.22 ETO22021.1 - 2.6e-18 66.0 5.7 3e-18 65.8 5.7 1.1 1 0 0 1 1 1 1 Cullin family RasGAP_C PF03836.15 ETO22021.1 - 0.013 15.6 0.7 0.036 14.2 0.7 1.7 2 0 0 2 2 2 0 RasGAP C-terminus Zn_Tnp_IS1595 PF12760.7 ETO22022.1 - 3e-06 27.1 7.0 4.5e-06 26.5 7.0 1.3 1 0 0 1 1 1 1 Transposase zinc-ribbon domain DDE_Tnp_IS1595 PF12762.7 ETO22022.1 - 4.2e-06 26.8 0.1 6.7e-06 26.2 0.1 1.3 1 0 0 1 1 1 1 ISXO2-like transposase domain Sigma70_r4_2 PF08281.12 ETO22022.1 - 0.0017 18.0 0.0 0.0026 17.4 0.0 1.3 1 0 0 1 1 1 1 Sigma-70, region 4 HTH_1 PF00126.27 ETO22022.1 - 0.2 11.7 0.1 0.3 11.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial regulatory helix-turn-helix protein, lysR family zf-H2C2_2 PF13465.6 ETO22022.1 - 2.4 8.7 6.7 0.5 10.9 1.8 2.2 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2HE PF16278.5 ETO22022.1 - 2.9 8.4 7.0 9 6.8 1.2 2.8 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger BMFP PF04380.13 ETO22023.1 - 3.2e-15 56.4 0.5 8.3e-15 55.0 0.5 1.7 1 0 0 1 1 1 1 Membrane fusogenic activity HC2 PF07382.11 ETO22023.1 - 0.15 12.1 31.1 0.18 11.9 30.7 1.4 1 1 0 1 1 1 0 Histone H1-like nucleoprotein HC2 FlaA PF04620.12 ETO22023.1 - 0.39 10.3 3.0 0.44 10.2 2.1 1.5 1 1 1 2 2 2 0 Flagellar filament outer layer protein Flaa Peptidase_S49_N PF08496.10 ETO22023.1 - 1.7 8.7 8.0 2.5 8.2 8.0 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal N6_Mtase PF02384.16 ETO22024.1 - 8e-31 107.5 0.2 8e-31 107.5 0.2 3.4 2 1 2 4 4 4 1 N-6 DNA Methylase Methylase_S PF01420.19 ETO22024.1 - 5.7e-12 46.2 15.5 9.3e-11 42.2 3.4 4.7 3 2 1 4 4 4 2 Type I restriction modification DNA specificity domain UPF0020 PF01170.18 ETO22024.1 - 4.2e-08 33.1 0.1 4.4e-07 29.8 0.0 2.3 2 0 0 2 2 2 1 Putative RNA methylase family UPF0020 HSDR_N_2 PF13588.6 ETO22024.1 - 7.8e-08 32.3 3.0 7.9e-08 32.3 0.1 2.6 3 0 0 3 3 3 1 Type I restriction enzyme R protein N terminus (HSDR_N) AviRa PF11599.8 ETO22024.1 - 0.041 13.3 0.1 1.9 7.9 0.0 3.0 3 0 0 3 3 3 0 RRNA methyltransferase AviRa Phage_GPO PF05929.11 ETO22025.1 - 0.74 9.4 12.5 1.1 8.9 12.5 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase FAM76 PF16046.5 ETO22025.1 - 1.3 8.3 24.1 1.6 8.0 23.4 1.6 1 1 0 1 1 1 0 FAM76 protein DUF4407 PF14362.6 ETO22025.1 - 9.5 5.5 14.7 13 5.0 14.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) UAA PF08449.11 ETO22026.1 - 3.6e-34 118.3 12.6 4.7e-34 118.0 12.6 1.0 1 0 0 1 1 1 1 UAA transporter family TPT PF03151.16 ETO22026.1 - 1e-05 25.1 10.5 1.3e-05 24.7 10.5 1.0 1 0 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ETO22026.1 - 0.00039 20.6 11.5 0.055 13.7 1.1 2.4 2 1 0 2 2 2 2 EamA-like transporter family DMT_YdcZ PF04657.13 ETO22026.1 - 0.043 14.1 5.7 0.037 14.3 4.2 1.7 1 1 0 1 1 1 0 Putative inner membrane exporter, YdcZ HlyD_2 PF12700.7 ETO22026.1 - 1.2 7.7 3.1 1.7 7.3 3.1 1.1 1 0 0 1 1 1 0 HlyD family secretion protein Sigma70_ner PF04546.13 ETO22027.1 - 0.011 15.6 2.6 0.013 15.4 2.6 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region CDC45 PF02724.14 ETO22027.1 - 0.071 11.4 5.6 0.083 11.2 5.6 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF3953 PF13129.6 ETO22027.1 - 0.16 11.8 0.1 0.28 11.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3953) DNA_pol_phi PF04931.13 ETO22027.1 - 0.58 8.2 8.8 0.65 8.0 8.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ETO22027.1 - 2.9 8.3 15.0 4.5 7.7 15.0 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RXT2_N PF08595.11 ETO22027.1 - 3.9 7.5 7.9 5.9 6.9 7.9 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal FAM176 PF14851.6 ETO22027.1 - 7.1 6.3 6.1 12 5.6 6.1 1.4 1 0 0 1 1 1 0 FAM176 family AF-4 PF05110.13 ETO22030.1 - 4.9 5.1 27.1 5.8 4.9 27.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein FUN14 PF04930.15 ETO22031.1 - 1.2e-11 44.8 2.6 3.1e-11 43.5 2.6 1.7 1 0 0 1 1 1 1 FUN14 family SPC12 PF06645.13 ETO22031.1 - 0.052 13.6 0.3 0.093 12.8 0.3 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) DUF5336 PF17270.2 ETO22031.1 - 0.089 12.4 0.0 0.18 11.4 0.0 1.5 1 1 1 2 2 2 0 Family of unknown function (DUF5336) Ank_2 PF12796.7 ETO22032.1 - 0.00034 21.2 0.0 0.00093 19.7 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) PDDEXK_10 PF07788.11 ETO22032.1 - 0.0046 16.9 0.2 0.012 15.5 0.2 1.6 1 0 0 1 1 1 1 PD-(D/E)XK nuclease superfamily Ank_3 PF13606.6 ETO22032.1 - 0.0069 16.8 0.0 0.7 10.6 0.0 3.6 3 0 0 3 3 3 1 Ankyrin repeat MIF4G_like_2 PF09090.11 ETO22032.1 - 0.15 11.5 3.1 0.29 10.6 3.1 1.5 1 0 0 1 1 1 0 MIF4G like CDT1_C PF16679.5 ETO22032.1 - 1.4 9.4 7.9 0.34 11.4 0.2 2.6 2 0 0 2 2 2 0 DNA replication factor Cdt1 C-terminal domain cNMP_binding PF00027.29 ETO22033.1 - 2.1e-36 123.8 0.0 6.2e-18 64.7 0.0 3.3 3 0 0 3 3 3 3 Cyclic nucleotide-binding domain SR-25 PF10500.9 ETO22035.1 - 0.96 9.0 17.8 1.4 8.4 17.8 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Transket_pyr PF02779.24 ETO22037.1 - 3.6e-59 199.4 0.0 1e-58 198.0 0.0 1.7 2 0 0 2 2 2 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ETO22037.1 - 4.9e-56 189.9 0.3 4.9e-50 170.2 0.2 2.2 2 0 0 2 2 2 2 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ETO22037.1 - 3.4e-36 124.2 0.0 7.4e-36 123.1 0.0 1.5 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal DUF5359 PF17313.2 ETO22038.1 - 0.01 15.8 3.7 0.032 14.2 3.7 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5359) DUF4200 PF13863.6 ETO22038.1 - 2.9 8.3 8.1 0.48 10.8 0.5 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4200) UCH PF00443.29 ETO22039.1 - 4.7e-16 59.1 0.2 5.6e-16 58.8 0.2 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO22039.1 - 3.8e-11 43.2 1.3 4.3e-11 43.0 1.3 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO22040.1 - 6.5e-05 22.5 6.9 0.014 14.9 0.0 2.1 2 0 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Rhodanese PF00581.20 ETO22041.1 - 9.5e-07 29.3 0.1 3.6e-06 27.5 0.0 1.9 1 1 1 2 2 2 1 Rhodanese-like domain Menin PF05053.13 ETO22041.1 - 0.099 11.0 14.1 0.11 10.8 14.1 1.1 1 0 0 1 1 1 0 Menin Membralin PF09746.9 ETO22041.1 - 0.35 9.8 2.5 0.49 9.4 2.5 1.2 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO22041.1 - 0.59 8.8 7.7 0.74 8.5 7.7 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO22041.1 - 0.63 10.1 2.3 0.79 9.7 2.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.9 ETO22041.1 - 0.67 8.4 9.9 0.71 8.4 9.9 1.2 1 0 0 1 1 1 0 Macoilin family NPR3 PF03666.13 ETO22041.1 - 3 6.5 9.0 4.1 6.1 9.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RabGAP-TBC PF00566.18 ETO22042.1 - 4.2e-32 111.6 7.4 6.1e-30 104.5 5.2 2.3 2 0 0 2 2 2 2 Rab-GTPase-TBC domain DUF2052 PF09747.9 ETO22042.1 - 3.1 7.9 8.8 0.61 10.2 3.3 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF4637 PF15470.6 ETO22042.1 - 4.7 6.9 7.1 4.7 6.9 4.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Tocopherol_cycl PF14249.6 ETO22043.1 - 0.12 11.4 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Tocopherol cyclase BTB PF00651.31 ETO22044.1 - 0.011 16.0 0.4 0.019 15.2 0.0 1.6 2 0 0 2 2 2 0 BTB/POZ domain BCLP PF12304.8 ETO22044.1 - 0.044 13.3 0.0 0.071 12.6 0.0 1.3 1 0 0 1 1 1 0 Beta-casein like protein USP7_ICP0_bdg PF12436.8 ETO22045.1 - 1.2e-19 70.6 0.2 2.7e-19 69.4 0.2 1.6 1 0 0 1 1 1 1 ICP0-binding domain of Ubiquitin-specific protease 7 Cytadhesin_P30 PF07271.11 ETO22045.1 - 4 6.9 11.6 7.5 6.0 11.6 1.4 1 0 0 1 1 1 0 Cytadhesin P30/P32 DUF4834 PF16118.5 ETO22046.1 - 0.0025 18.7 2.8 0.71 10.9 0.2 3.4 3 0 0 3 3 3 2 Domain of unknown function (DUF4834) DUF4229 PF14012.6 ETO22046.1 - 0.0034 17.4 0.0 10 6.3 0.0 4.1 3 0 0 3 3 3 1 Protein of unknown function (DUF4229) Yip1 PF04893.17 ETO22046.1 - 0.085 12.6 11.4 4.4 7.0 2.8 4.4 4 1 0 4 4 4 0 Yip1 domain RuvC_III PF18541.1 ETO22046.1 - 0.1 12.5 0.1 0.1 12.5 0.1 2.6 3 0 0 3 3 3 0 RuvC endonuclease subdomain 3 AIF_C PF14721.6 ETO22046.1 - 0.1 13.0 0.7 1 9.7 0.2 2.4 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term OppC_N PF12911.7 ETO22046.1 - 0.22 11.5 1.0 0.97 9.5 0.0 2.6 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C Jagunal PF07086.12 ETO22046.1 - 0.26 11.3 11.4 8.9 6.3 0.1 4.3 3 1 1 4 4 4 0 Jagunal, ER re-organisation during oogenesis Orf78 PF06024.12 ETO22046.1 - 6.8 7.1 7.5 9.6 6.6 0.5 3.9 2 1 2 4 4 4 0 Orf78 (ac78) Mucin PF01456.17 ETO22047.1 - 0.23 11.4 15.9 0.43 10.6 15.9 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein TFIIA PF03153.13 ETO22047.1 - 5.3 6.9 10.6 5.9 6.8 10.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FlaC_arch PF05377.11 ETO22048.1 - 0.088 13.2 1.1 0.67 10.4 0.1 2.7 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF641 PF04859.12 ETO22048.1 - 0.46 10.8 4.8 0.31 11.4 0.6 2.5 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) Pirin PF02678.16 ETO22049.1 - 6.3e-16 58.3 2.0 8.9e-10 38.5 0.2 3.0 3 0 0 3 3 3 2 Pirin Pirin_C PF05726.13 ETO22049.1 - 8.5e-08 32.5 0.0 2e-07 31.3 0.0 1.6 1 0 0 1 1 1 1 Pirin C-terminal cupin domain Abhydrolase_3 PF07859.13 ETO22050.1 - 4.9e-32 111.5 0.3 1.4e-30 106.7 0.0 2.2 1 1 1 2 2 2 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETO22050.1 - 1e-08 34.5 0.0 2.6e-06 26.6 0.0 2.2 1 1 1 2 2 2 2 Steryl acetyl hydrolase Hydrolase_4 PF12146.8 ETO22050.1 - 0.0009 18.6 0.0 0.013 14.8 0.0 2.3 1 1 1 2 2 2 1 Serine aminopeptidase, S33 Nucleo_P87 PF07267.11 ETO22050.1 - 0.09 11.6 10.6 0.14 11.0 10.6 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DLH PF01738.18 ETO22050.1 - 0.12 11.9 0.2 0.77 9.3 0.0 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Chlorophyllase2 PF12740.7 ETO22050.1 - 0.14 11.0 0.0 0.25 10.2 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme PET117 PF15786.5 ETO22050.1 - 4.6 7.6 5.7 13 6.1 5.7 1.8 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial CAML PF14963.6 ETO22051.1 - 0.54 10.4 2.7 0.84 9.7 2.7 1.2 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand tRNA-synt_1 PF00133.22 ETO22052.1 - 1.1e-93 314.6 0.1 2.3e-82 277.2 0.1 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETO22052.1 - 5.6e-07 28.7 0.6 0.0012 17.7 0.6 2.2 2 0 0 2 2 2 2 tRNA synthetases class I (M) GspH PF12019.8 ETO22052.1 - 0.072 13.5 0.0 0.13 12.7 0.0 1.4 1 0 0 1 1 1 0 Type II transport protein GspH tRNA-synt_1 PF00133.22 ETO22053.1 - 6.2e-51 173.4 1.6 6.7e-51 173.3 1.6 1.0 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) DUF4661 PF15576.6 ETO22054.1 - 0.14 12.1 0.4 0.22 11.4 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) ART PF01129.18 ETO22055.1 - 6e-05 22.4 0.3 0.00012 21.5 0.3 1.5 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase PUB PF09409.10 ETO22055.1 - 0.0046 16.9 0.9 0.022 14.7 0.2 2.6 2 1 0 2 2 2 1 PUB domain FokI_C PF02980.16 ETO22055.1 - 0.028 14.4 0.5 0.075 13.1 0.5 1.7 1 0 0 1 1 1 0 Restriction endonuclease FokI, catalytic domain TPR_12 PF13424.6 ETO22057.1 - 9.9e-46 153.9 13.9 1.1e-14 54.4 0.6 5.2 2 1 4 6 6 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22057.1 - 6.4e-35 116.6 7.7 3.3e-08 33.0 0.0 6.5 5 1 1 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22057.1 - 8.5e-35 117.7 0.5 1.7e-09 37.3 0.0 6.5 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22057.1 - 2.4e-30 103.1 32.1 1.2e-07 31.2 0.2 6.9 6 1 1 7 7 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22057.1 - 3.4e-22 76.8 31.2 3.2e-06 26.9 0.2 6.5 5 1 1 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22057.1 - 8.6e-21 72.3 23.7 1.4e-05 24.8 2.2 6.7 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22057.1 - 3.1e-12 46.0 5.0 0.015 15.7 0.4 6.1 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22057.1 - 1.3e-08 34.9 3.2 0.042 14.5 0.5 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22057.1 - 2.4e-06 28.1 0.2 0.95 10.2 0.0 5.1 3 3 1 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22057.1 - 5.9e-06 26.7 0.0 5.2 8.1 0.0 5.2 4 1 1 5 5 5 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO22057.1 - 9.4e-05 22.3 14.8 0.095 12.5 0.4 5.2 2 2 1 4 4 4 3 Domain of unknown function (DUF5113) Peptidase_C14 PF00656.22 ETO22057.1 - 0.00019 21.5 2.9 0.00019 21.5 2.9 2.3 2 1 0 2 2 2 1 Caspase domain TPR_11 PF13414.6 ETO22057.1 - 0.004 16.8 27.2 0.28 10.9 0.1 7.0 5 3 2 7 7 7 2 TPR repeat DUF896 PF05979.12 ETO22057.1 - 0.013 15.3 0.3 0.055 13.4 0.3 2.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF896) TPR_3 PF07720.12 ETO22057.1 - 0.017 15.1 21.6 0.65 10.1 0.0 6.4 7 0 0 7 7 7 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO22057.1 - 0.11 12.1 5.4 26 4.5 0.0 4.9 4 1 1 5 5 5 0 Helix-turn-helix bacterial domain PPR PF01535.20 ETO22057.1 - 0.23 11.8 13.7 9.1 6.8 0.1 6.8 7 1 1 8 8 7 0 PPR repeat MIT PF04212.18 ETO22057.1 - 0.42 10.7 19.3 0.75 9.9 0.1 5.5 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain EamA PF00892.20 ETO22058.1 - 7.7e-24 84.4 36.4 4.1e-13 49.7 16.8 3.0 2 1 1 3 3 3 3 EamA-like transporter family Pox_Ag35 PF03286.14 ETO22060.1 - 0.0028 17.5 11.3 0.0028 17.5 11.3 3.5 2 1 1 3 3 3 1 Pox virus Ag35 surface protein BSP_II PF05432.11 ETO22060.1 - 0.003 17.3 51.5 0.0035 17.1 23.2 2.9 3 0 0 3 3 3 2 Bone sialoprotein II (BSP-II) CENP-B_dimeris PF09026.10 ETO22060.1 - 0.0039 17.5 4.3 0.0039 17.5 4.3 3.8 2 1 1 3 3 3 1 Centromere protein B dimerisation domain CDC45 PF02724.14 ETO22060.1 - 1.1 7.5 41.2 1.1 7.5 21.3 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF2052 PF09747.9 ETO22060.1 - 2.4 8.3 50.4 0.17 12.0 16.9 3.0 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) TERB2 PF15101.6 ETO22060.1 - 4.8 7.2 17.8 0.27 11.2 0.8 2.8 3 0 0 3 3 3 0 Telomere-associated protein TERB2 Glyco_hydro_47 PF01532.20 ETO22061.1 - 3e-13 49.5 0.8 1.1e-08 34.4 0.1 2.2 2 0 0 2 2 2 2 Glycosyl hydrolase family 47 CENP-B_dimeris PF09026.10 ETO22061.1 - 0.091 13.2 5.1 0.21 12.0 5.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain ERF PF04404.12 ETO22061.1 - 2.7 7.8 9.3 34 4.3 10.8 2.1 2 0 0 2 2 2 0 ERF superfamily NOA36 PF06524.12 ETO22061.1 - 3.4 6.9 10.2 6.9 5.9 10.2 1.5 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 ETO22061.1 - 5.3 6.1 12.0 8.2 5.4 12.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TPR_12 PF13424.6 ETO22064.1 - 4.8e-85 279.9 24.8 6.5e-22 77.6 0.1 6.4 3 2 2 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22064.1 - 3e-68 224.0 10.7 1.2e-09 37.8 0.0 9.3 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22064.1 - 3.1e-58 189.6 14.5 8.8e-08 31.7 0.1 8.6 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22064.1 - 4.9e-56 184.4 44.2 4.5e-09 35.7 1.7 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22064.1 - 3.2e-48 157.9 35.5 1.4e-06 28.0 0.1 9.1 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22064.1 - 3.1e-37 123.7 36.1 6.8e-06 25.8 0.1 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22064.1 - 4.6e-23 79.9 10.2 0.012 16.0 0.0 9.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22064.1 - 4.2e-18 64.5 0.3 0.92 10.5 0.0 8.5 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22064.1 - 5.1e-15 55.0 5.0 0.29 11.9 0.0 8.1 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22064.1 - 6e-15 54.7 33.8 0.012 15.3 0.1 10.1 8 3 1 9 9 9 5 TPR repeat TPR_MalT PF17874.1 ETO22064.1 - 2e-10 40.6 0.2 4e-05 23.1 0.0 3.1 1 1 2 3 3 3 3 MalT-like TPR region TPR_16 PF13432.6 ETO22064.1 - 4.9e-10 39.9 3.9 3.4 8.4 0.0 6.9 5 2 1 6 6 6 2 Tetratricopeptide repeat RPN7 PF10602.9 ETO22064.1 - 2.2e-08 34.0 10.1 0.01 15.5 0.0 4.8 3 2 0 4 4 4 2 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETO22064.1 - 5.6e-07 30.0 10.1 0.15 12.6 0.0 6.1 6 1 0 6 6 6 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO22064.1 - 1.5e-06 28.1 17.7 0.028 14.4 1.3 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETO22064.1 - 2.1e-06 27.7 18.4 2.2 8.1 0.1 7.4 5 2 2 7 7 7 2 Domain of unknown function (DUF5113) MIT PF04212.18 ETO22064.1 - 1.1e-05 25.3 23.5 0.19 11.8 0.0 7.8 7 1 1 8 8 8 2 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO22064.1 - 0.001 19.2 13.1 1.1 9.6 0.1 4.9 3 2 3 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_4 PF07721.14 ETO22064.1 - 0.0041 17.6 0.0 68 4.5 0.0 4.9 5 0 0 5 5 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO22064.1 - 0.0044 16.5 5.9 22 4.6 0.0 6.6 8 0 0 8 8 8 0 SHNi-TPR Sel1 PF08238.12 ETO22064.1 - 0.0054 17.4 6.5 35 5.3 0.0 6.5 6 0 0 6 6 6 0 Sel1 repeat PPR PF01535.20 ETO22064.1 - 0.029 14.6 10.3 9.4 6.7 0.0 6.4 7 0 0 7 7 7 0 PPR repeat BTAD PF03704.17 ETO22064.1 - 0.083 13.3 0.2 1.7 9.1 0.0 3.2 3 1 0 3 3 2 0 Bacterial transcriptional activator domain ING PF12998.7 ETO22065.1 - 0.0042 17.7 2.2 0.0097 16.5 2.2 1.8 1 0 0 1 1 1 1 Inhibitor of growth proteins N-terminal histone-binding CoaE PF01121.20 ETO22065.1 - 0.0071 16.0 0.9 0.0091 15.7 0.9 1.2 1 0 0 1 1 1 1 Dephospho-CoA kinase Foamy_virus_ENV PF03408.14 ETO22065.1 - 0.066 11.1 1.8 0.087 10.7 0.4 1.7 1 1 1 2 2 2 0 Foamy virus envelope protein YtxH PF12732.7 ETO22065.1 - 0.077 13.5 0.7 0.16 12.5 0.2 1.8 2 1 0 2 2 2 0 YtxH-like protein DUF1664 PF07889.12 ETO22065.1 - 0.18 11.8 5.4 0.2 11.7 4.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Exonuc_VII_L PF02601.15 ETO22065.1 - 0.97 8.9 5.0 1.1 8.7 5.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit RasGEF_N_2 PF14663.6 ETO22065.1 - 1 9.8 5.5 1 9.8 0.1 2.6 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain HIP1_clath_bdg PF16515.5 ETO22065.1 - 1.1 9.9 10.7 6.4 7.5 4.9 2.2 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fzo_mitofusin PF04799.13 ETO22065.1 - 1.3 8.5 8.0 0.41 10.2 0.8 1.9 1 1 1 2 2 2 0 fzo-like conserved region NOA36 PF06524.12 ETO22066.1 - 0.066 12.5 21.0 0.16 11.2 21.0 1.6 1 0 0 1 1 1 0 NOA36 protein RNA_pol_3_Rpc31 PF11705.8 ETO22066.1 - 0.45 10.7 26.0 0.81 9.9 26.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 MAP7 PF05672.11 ETO22066.1 - 0.52 10.0 29.6 0.027 14.2 22.8 2.0 2 0 0 2 2 2 0 MAP7 (E-MAP-115) family Presenilin PF01080.17 ETO22066.1 - 1.2 7.8 15.9 1.7 7.3 15.9 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO22066.1 - 1.8 7.0 23.7 2.7 6.4 23.7 1.2 1 0 0 1 1 1 0 Macoilin family Astro_capsid_p PF12226.8 ETO22066.1 - 2.5 7.1 17.1 4.2 6.4 17.1 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CobT PF06213.12 ETO22066.1 - 5.4 6.3 23.4 8.2 5.7 23.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RPN2_C PF18004.1 ETO22066.1 - 6.2 6.7 26.6 2.9 7.8 23.3 2.0 1 1 1 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain HEAT_EZ PF13513.6 ETO22067.1 - 0.14 12.7 0.1 11 6.7 0.0 3.3 3 1 1 4 4 4 0 HEAT-like repeat Ank PF00023.30 ETO22069.1 - 1.5e-14 53.6 0.1 3.1e-07 30.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETO22069.1 - 1.4e-13 51.1 0.1 1.9e-11 44.2 0.1 2.8 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO22069.1 - 1.4e-13 50.7 0.2 3.4e-10 40.0 0.1 2.5 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO22069.1 - 6.8e-13 47.5 0.0 7.8e-07 28.9 0.0 2.9 2 0 0 2 2 2 2 Ankyrin repeat Ank_2 PF12796.7 ETO22069.1 - 8.5e-13 48.7 0.0 2.1e-12 47.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) RdRP_4 PF02123.16 ETO22072.1 - 0.072 12.0 1.1 0.083 11.8 1.1 1.1 1 0 0 1 1 1 0 Viral RNA-directed RNA-polymerase Ferritin-like PF12902.7 ETO22072.1 - 1.7 8.4 4.5 1.6 8.6 0.1 2.4 1 1 2 3 3 3 0 Ferritin-like FH2 PF02181.23 ETO22073.1 - 2.1e-27 96.3 0.2 2.3e-27 96.1 0.2 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Ac76 PF05814.11 ETO22074.1 - 0.15 12.1 1.5 0.83 9.7 0.3 2.1 2 0 0 2 2 2 0 Orf76 (Ac76) zf-RanBP PF00641.18 ETO22075.1 - 0.00096 18.4 6.7 0.0022 17.3 6.7 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Porin_OmpG PF09381.10 ETO22075.1 - 0.027 14.3 0.0 0.045 13.5 0.0 1.4 1 0 0 1 1 1 0 Outer membrane protein G (OmpG) Exonuc_VII_L PF02601.15 ETO22075.1 - 0.18 11.3 11.4 0.3 10.6 11.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Enterotoxin_b PF01376.18 ETO22075.1 - 0.35 11.1 2.8 0.28 11.4 0.3 2.1 2 0 0 2 2 2 0 Heat-labile enterotoxin beta chain ERM PF00769.19 ETO22076.1 - 2.7e-06 27.4 8.0 3.2e-06 27.1 8.0 1.0 1 0 0 1 1 1 1 Ezrin/radixin/moesin family HAUS-augmin3 PF14932.6 ETO22076.1 - 5.5e-05 22.9 5.4 7.2e-05 22.5 5.4 1.2 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 3 Exonuc_VII_L PF02601.15 ETO22076.1 - 0.00073 19.2 7.5 0.00092 18.9 7.5 1.1 1 0 0 1 1 1 1 Exonuclease VII, large subunit Filament PF00038.21 ETO22076.1 - 0.0016 18.1 11.6 0.0023 17.6 11.6 1.2 1 0 0 1 1 1 1 Intermediate filament protein FAM184 PF15665.5 ETO22076.1 - 0.0037 17.1 10.6 0.0054 16.5 10.6 1.2 1 0 0 1 1 1 1 Family with sequence similarity 184, A and B CENP-Q PF13094.6 ETO22076.1 - 0.0055 16.9 3.2 0.0064 16.7 3.2 1.2 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit DUF5082 PF16888.5 ETO22076.1 - 0.0097 16.2 9.8 0.017 15.4 9.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) Dor1 PF04124.12 ETO22076.1 - 0.013 14.2 10.1 0.017 13.9 10.1 1.1 1 0 0 1 1 1 0 Dor1-like family FapA PF03961.13 ETO22076.1 - 0.032 12.9 10.8 0.037 12.6 10.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMPIT PF07851.13 ETO22076.1 - 0.051 12.8 8.3 0.067 12.4 8.3 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF4472 PF14739.6 ETO22076.1 - 0.07 13.9 12.8 0.11 13.3 12.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) UPF0242 PF06785.11 ETO22076.1 - 0.072 13.2 11.7 0.12 12.5 11.7 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus GAS PF13851.6 ETO22076.1 - 0.11 11.8 19.3 0.34 10.2 7.3 2.1 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding HIP1_clath_bdg PF16515.5 ETO22076.1 - 0.13 12.9 14.5 1.1 9.9 14.5 2.0 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TraC_F_IV PF11130.8 ETO22076.1 - 0.15 11.7 2.0 2.1 7.9 0.6 2.2 1 1 1 2 2 2 0 F pilus assembly Type-IV secretion system for plasmid transfer APG6_N PF17675.1 ETO22076.1 - 0.19 12.2 16.0 0.26 11.8 15.2 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF4201 PF13870.6 ETO22076.1 - 0.22 11.2 16.6 0.8 9.4 6.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4201) Golgin_A5 PF09787.9 ETO22076.1 - 0.22 10.9 12.6 0.31 10.5 12.6 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 HCMV_UL139 PF12507.8 ETO22076.1 - 0.24 11.8 6.7 0.58 10.6 4.6 2.0 1 1 1 2 2 2 0 Human Cytomegalovirus UL139 protein Prefoldin_2 PF01920.20 ETO22076.1 - 0.25 11.3 16.9 0.15 12.0 3.6 2.5 1 1 2 3 3 3 0 Prefoldin subunit XhlA PF10779.9 ETO22076.1 - 0.27 11.5 10.3 0.54 10.5 2.0 2.5 2 0 0 2 2 2 0 Haemolysin XhlA YscO PF07321.12 ETO22076.1 - 0.28 11.1 11.5 0.85 9.6 3.9 2.1 1 1 1 2 2 2 0 Type III secretion protein YscO ADIP PF11559.8 ETO22076.1 - 0.29 11.2 17.4 0.45 10.6 17.4 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding ATG16 PF08614.11 ETO22076.1 - 0.29 11.3 14.2 0.4 10.9 14.2 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) OmpH PF03938.14 ETO22076.1 - 0.33 11.3 13.8 0.64 10.4 13.8 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ABC_tran_CTD PF16326.5 ETO22076.1 - 0.34 11.2 12.8 0.11 12.7 8.5 2.1 1 1 1 2 2 2 0 ABC transporter C-terminal domain CdvA PF18822.1 ETO22076.1 - 0.35 10.7 14.8 1.4 8.7 3.4 2.2 1 1 1 2 2 2 0 CdvA-like coiled-coil domain FlxA PF14282.6 ETO22076.1 - 0.37 10.8 13.9 0.53 10.3 13.9 1.2 1 0 0 1 1 1 0 FlxA-like protein Prefoldin PF02996.17 ETO22076.1 - 0.37 10.7 12.2 1.7 8.6 4.8 2.4 1 1 1 2 2 2 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 ETO22076.1 - 0.39 10.9 12.3 0.65 10.2 12.3 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Sec2p PF06428.11 ETO22076.1 - 0.4 10.7 14.3 0.35 10.9 3.3 2.2 1 1 1 2 2 2 0 GDP/GTP exchange factor Sec2p YlqD PF11068.8 ETO22076.1 - 0.44 10.9 14.1 1 9.7 14.0 1.6 1 1 0 1 1 1 0 YlqD protein ZapB PF06005.12 ETO22076.1 - 0.46 11.0 19.3 0.81 10.2 5.7 2.1 1 1 1 2 2 2 0 Cell division protein ZapB DUF4407 PF14362.6 ETO22076.1 - 0.84 8.9 8.0 1.4 8.2 8.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spc7 PF08317.11 ETO22076.1 - 0.86 8.4 16.6 1.1 8.1 16.0 1.5 1 1 1 2 2 2 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ETO22076.1 - 0.92 10.0 9.4 4.8 7.7 1.6 2.4 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF641 PF04859.12 ETO22076.1 - 2.2 8.6 12.1 8.3 6.8 12.1 1.8 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) Fzo_mitofusin PF04799.13 ETO22076.1 - 2.2 7.8 10.5 5.7 6.5 0.4 2.3 1 1 0 2 2 2 0 fzo-like conserved region Spc24 PF08286.11 ETO22076.1 - 3.1 8.1 14.7 5.4 7.3 4.9 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Atg14 PF10186.9 ETO22076.1 - 3.8 6.5 12.3 5.1 6.1 12.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DivIC PF04977.15 ETO22076.1 - 4.3 7.2 13.5 0.57 10.0 2.7 2.6 1 1 0 2 2 2 0 Septum formation initiator Ax_dynein_light PF10211.9 ETO22076.1 - 4.5 7.2 18.5 1.9 8.4 11.7 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain TMF_DNA_bd PF12329.8 ETO22076.1 - 7.4 6.7 18.7 4.3 7.4 6.1 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding FliD_N PF02465.18 ETO22076.1 - 8 7.2 13.3 7.7 7.3 2.5 2.2 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Rho_Binding PF08912.11 ETO22076.1 - 8.4 7.3 17.7 2.3 9.1 6.3 2.4 1 1 1 2 2 2 0 Rho Binding Kelch_6 PF13964.6 ETO22078.1 - 1.3e-09 38.0 4.1 0.00038 20.6 0.1 3.9 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO22078.1 - 3.7e-06 26.7 1.1 0.02 14.9 0.0 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO22078.1 - 7.3e-06 25.9 1.1 0.005 16.8 0.0 3.5 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO22078.1 - 0.00024 20.6 1.4 0.039 13.6 0.0 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO22078.1 - 0.00081 19.6 0.6 0.0038 17.5 0.0 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO22078.1 - 0.071 12.3 0.1 2.2 7.4 0.1 2.4 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_5 PF13854.6 ETO22078.1 - 0.18 11.9 12.4 0.31 11.1 0.2 5.0 5 1 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO22080.1 - 2.1e-38 129.6 27.5 2.7e-07 31.1 2.4 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22080.1 - 2.9e-16 59.5 2.7 0.0048 17.2 0.0 6.0 4 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO22080.1 - 1.8e-10 40.1 6.3 0.034 12.8 0.5 4.8 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO22080.1 - 2.4e-07 30.4 7.1 0.084 12.2 1.0 5.2 1 1 3 4 4 4 3 WD40-like domain WD40 PF00400.32 ETO22081.1 - 5.5e-147 473.2 49.9 6.4e-11 42.6 0.1 15.0 15 0 0 15 15 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22081.1 - 1e-56 189.2 9.1 0.00018 21.8 0.0 14.0 1 1 13 14 14 14 14 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO22081.1 - 3.1e-23 82.6 7.9 0.00088 18.7 0.0 9.1 3 1 10 14 14 14 10 WD40-like domain NACHT PF05729.12 ETO22081.1 - 3.3e-10 40.1 0.0 6.2e-10 39.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PQQ_2 PF13360.6 ETO22081.1 - 2.7e-08 33.7 8.4 0.097 12.2 0.4 4.8 1 1 2 4 4 4 3 PQQ-like domain Pentapeptide PF00805.22 ETO22081.1 - 2.3e-07 30.3 3.0 8.8e-05 22.1 0.5 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Germane PF10646.9 ETO22081.1 - 1.4e-06 29.0 0.2 3.5 8.4 0.0 5.7 4 2 1 5 5 4 1 Sporulation and spore germination Pentapeptide_4 PF13599.6 ETO22081.1 - 0.00021 21.4 0.1 0.00074 19.6 0.1 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO22081.1 - 0.00062 19.6 28.6 59 3.8 0.0 12.2 13 0 0 13 13 13 0 WD40-like Beta Propeller Repeat AAA_14 PF13173.6 ETO22081.1 - 0.0012 18.9 0.5 0.0088 16.1 0.5 2.7 1 0 0 1 1 1 1 AAA domain RelA_SpoT PF04607.17 ETO22081.1 - 0.0014 18.9 2.2 0.0014 18.9 2.2 2.9 3 0 0 3 3 2 1 Region found in RelA / SpoT proteins AAA_18 PF13238.6 ETO22081.1 - 0.0023 18.5 0.0 0.0023 18.5 0.0 3.4 4 0 0 4 4 2 1 AAA domain AAA_22 PF13401.6 ETO22081.1 - 0.0043 17.3 0.0 0.013 15.8 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF3475 PF11961.8 ETO22081.1 - 0.0044 17.0 1.6 4.8 7.3 0.0 5.1 4 0 0 4 4 4 1 Domain of unknown function (DUF3475) AAA PF00004.29 ETO22081.1 - 0.032 14.7 0.1 0.11 12.9 0.0 2.0 2 0 0 2 2 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO22081.1 - 0.046 13.2 0.1 0.11 12.1 0.1 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ETO22081.1 - 0.093 13.1 1.4 0.63 10.5 0.1 3.2 2 1 0 2 2 2 0 RNA helicase Pentapeptide_3 PF13576.6 ETO22081.1 - 0.11 12.6 0.3 0.27 11.4 0.3 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO22081.1 - 0.75 9.9 18.2 6.4 6.9 0.2 7.1 3 3 3 7 7 7 0 Family of unknown function (DUF5570) ABC_tran PF00005.27 ETO22081.1 - 3.8 8.0 6.4 0.5 10.9 0.1 2.8 3 0 0 3 3 2 0 ABC transporter Pkinase PF00069.25 ETO22082.1 - 8.2e-10 38.5 0.5 3.6e-09 36.4 0.1 2.3 2 1 0 2 2 2 1 Protein kinase domain FAF PF11250.8 ETO22082.1 - 0.14 12.4 0.0 0.33 11.2 0.0 1.7 1 0 0 1 1 1 0 Fantastic Four meristem regulator RRM_1 PF00076.22 ETO22083.1 - 0.0052 16.6 0.3 0.0093 15.8 0.3 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Tam41_Mmp37 PF09139.11 ETO22084.1 - 7.4e-24 84.8 0.1 9.5e-24 84.4 0.1 1.1 1 0 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Tam41_Mmp37 PF09139.11 ETO22085.1 - 4.5e-11 42.7 2.0 9.1e-11 41.8 2.0 1.6 1 1 0 1 1 1 1 Phosphatidate cytidylyltransferase, mitochondrial Metallophos PF00149.28 ETO22086.1 - 2e-29 103.5 2.6 1.5e-27 97.4 2.6 2.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Trypan_PARP PF05887.11 ETO22086.1 - 0.21 11.6 5.4 0.76 9.8 5.4 1.9 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MadL PF03817.13 ETO22087.1 - 0.066 13.2 0.1 0.11 12.5 0.1 1.3 1 0 0 1 1 1 0 Malonate transporter MadL subunit SUIM_assoc PF16619.5 ETO22087.1 - 1.2 9.3 8.4 15 5.7 9.8 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Spt20 PF12090.8 ETO22087.1 - 4.8 6.7 9.6 0.19 11.3 3.5 1.9 2 0 0 2 2 2 0 Spt20 family Mic1 PF07035.12 ETO22089.1 - 0.21 11.3 2.8 10 5.8 0.0 3.0 2 1 1 3 3 3 0 Colon cancer-associated protein Mic1-like TPR_12 PF13424.6 ETO22090.1 - 1.1e-68 227.5 32.0 3.7e-11 43.2 0.5 10.6 8 2 2 10 10 10 10 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22090.1 - 4.3e-41 137.1 51.0 0.00018 21.2 0.0 17.2 17 1 0 17 17 17 10 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22090.1 - 1.3e-39 133.0 24.5 0.00024 20.9 0.1 15.5 17 0 0 17 17 17 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22090.1 - 2.6e-37 123.9 50.0 0.0018 18.3 0.0 17.0 17 1 0 17 17 17 10 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22090.1 - 2.8e-33 111.5 30.4 0.00092 19.1 0.2 15.7 15 1 1 16 16 16 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22090.1 - 2.8e-13 48.9 36.7 0.49 10.8 0.1 13.6 15 0 0 15 15 13 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22090.1 - 5.1e-12 45.6 3.2 2.4 9.2 0.0 11.8 14 1 1 15 15 14 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22090.1 - 1.5e-09 37.8 15.4 4.9 8.0 0.0 10.4 11 0 0 11 11 10 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22090.1 - 2e-07 30.9 12.9 6.7 7.3 0.0 10.1 11 0 0 11 11 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22090.1 - 1.9e-05 25.2 0.0 2.4 8.9 0.0 6.5 7 0 0 7 7 6 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO22090.1 - 7.1e-05 23.0 36.6 0.13 12.5 0.1 9.7 7 2 2 9 9 9 3 Anaphase-promoting complex, cyclosome, subunit 3 SAND PF01342.21 ETO22090.1 - 0.0015 18.2 12.6 7.1 6.4 0.1 6.9 7 1 0 7 7 7 1 SAND domain AAR2 PF05282.11 ETO22090.1 - 0.0056 16.1 0.8 0.0056 16.1 0.8 3.1 3 1 2 5 5 5 1 AAR2 protein DUF5113 PF17140.4 ETO22090.1 - 0.0077 16.0 27.9 0.16 11.7 0.2 8.2 8 2 1 9 9 9 2 Domain of unknown function (DUF5113) HTH_28 PF13518.6 ETO22090.1 - 0.044 13.9 0.3 36 4.6 0.0 3.6 3 0 0 3 3 3 0 Helix-turn-helix domain PPR PF01535.20 ETO22090.1 - 0.15 12.4 10.1 25 5.4 0.0 8.3 11 0 0 11 11 10 0 PPR repeat TPR_11 PF13414.6 ETO22090.1 - 1.1 9.0 19.0 49 3.7 0.0 9.4 12 0 0 12 12 12 0 TPR repeat Clathrin PF00637.20 ETO22090.1 - 1.4 8.7 26.6 0.26 11.1 0.1 7.6 8 2 1 9 9 8 0 Region in Clathrin and VPS SHNi-TPR PF10516.9 ETO22090.1 - 1.7 8.2 7.3 5.1 6.6 0.0 5.0 6 1 1 7 7 7 0 SHNi-TPR PAP2 PF01569.21 ETO22091.1 - 3.3e-16 59.3 7.6 3.3e-16 59.3 7.6 2.7 1 1 1 2 2 2 1 PAP2 superfamily DUF5510 PF17629.2 ETO22091.1 - 0.073 13.0 0.1 0.26 11.3 0.1 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5510) PAP2_3 PF14378.6 ETO22091.1 - 2 8.0 17.8 1.7 8.3 3.1 3.0 2 1 1 3 3 3 0 PAP2 superfamily CTP_transf_like PF01467.26 ETO22093.1 - 3.4e-07 30.5 0.0 2.6e-06 27.7 0.0 2.4 1 1 0 1 1 1 1 Cytidylyltransferase-like PDZ_4 PF17816.1 ETO22093.1 - 0.064 13.7 0.4 0.56 10.6 0.1 2.3 2 0 0 2 2 2 0 PDZ domain Cas_GSU0053 PF09617.10 ETO22094.1 - 0.055 13.4 0.0 0.068 13.1 0.0 1.3 1 0 0 1 1 1 0 CRISPR-associated protein GSU0053 (Cas_GSU0053) Defensin_RK-1 PF17860.1 ETO22094.1 - 0.073 13.6 1.4 0.14 12.6 1.4 1.5 1 0 0 1 1 1 0 RK-1-like defensin Metallophos PF00149.28 ETO22095.1 - 1.2e-05 25.9 0.5 1.6e-05 25.5 0.5 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase AAA_lid_3 PF17862.1 ETO22097.1 - 0.053 13.3 0.2 0.091 12.6 0.2 1.3 1 0 0 1 1 1 0 AAA+ lid domain DUF1776 PF08643.10 ETO22098.1 - 0.013 14.9 0.7 0.015 14.7 0.7 1.1 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Apolipoprotein PF01442.18 ETO22098.1 - 0.033 14.0 3.4 0.038 13.9 3.0 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain Vps39_2 PF10367.9 ETO22098.1 - 0.065 13.7 4.3 0.071 13.6 3.4 1.5 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 Pox_F16 PF04708.12 ETO22098.1 - 0.086 12.3 3.8 0.1 12.0 3.8 1.2 1 0 0 1 1 1 0 Poxvirus F16 protein DNA_primase_lrg PF04104.14 ETO22098.1 - 0.089 12.2 3.3 0.11 11.9 3.3 1.1 1 0 0 1 1 1 0 Eukaryotic and archaeal DNA primase, large subunit Plasmod_dom_1 PF09715.10 ETO22098.1 - 0.1 12.7 0.7 0.22 11.6 0.1 1.8 1 1 1 2 2 2 0 Plasmodium protein of unknown function (Plasmod_dom_1) DUF883 PF05957.13 ETO22098.1 - 0.22 12.1 2.4 0.28 11.8 0.7 1.8 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Hydin_ADK PF17213.3 ETO22098.1 - 0.26 11.6 5.1 0.3 11.3 5.1 1.0 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Ground-like PF04155.18 ETO22098.1 - 0.3 11.8 4.7 0.1 13.2 1.3 1.9 1 1 1 2 2 2 0 Ground-like domain ZapB PF06005.12 ETO22098.1 - 0.91 10.0 10.8 3.4 8.2 9.6 1.9 2 0 0 2 2 2 0 Cell division protein ZapB SOAR PF16533.5 ETO22098.1 - 1.2 9.1 9.3 1.3 9.0 6.2 2.0 1 1 1 2 2 2 0 STIM1 Orai1-activating region YtxH PF12732.7 ETO22098.1 - 3 8.4 6.5 9.7 6.8 6.5 1.8 1 1 0 1 1 1 0 YtxH-like protein Corazonin PF17308.2 ETO22100.1 - 0.0034 17.8 9.9 0.0034 17.8 9.9 2.2 2 1 0 2 2 2 1 Pro-corazonin DUF3763 PF12592.8 ETO22100.1 - 0.01 15.8 0.1 0.019 15.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3763) POX PF07526.11 ETO22100.1 - 7.7 7.1 6.9 0.86 10.2 2.1 1.7 2 0 0 2 2 2 0 Associated with HOX XRN_M PF17846.1 ETO22101.1 - 1.1e-09 37.8 2.8 1.3e-09 37.5 2.8 1.1 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 ETO22101.1 - 0.001 18.5 0.3 0.0014 18.2 0.3 1.2 1 0 0 1 1 1 1 XRN 5'-3' exonuclease N-terminus VIT1 PF01988.19 ETO22101.1 - 0.091 12.6 0.1 0.095 12.6 0.1 1.2 1 0 0 1 1 1 0 VIT family SP_C-Propep PF08999.10 ETO22101.1 - 0.31 10.9 3.6 0.46 10.3 3.6 1.3 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Sec39 PF08314.11 ETO22103.1 - 0.0059 15.1 0.6 0.0059 15.1 0.6 1.0 1 0 0 1 1 1 1 Secretory pathway protein Sec39 Peptidase_S49_N PF08496.10 ETO22103.1 - 0.0086 16.1 1.6 0.0099 15.9 1.6 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal EcKinase PF02958.20 ETO22103.1 - 0.014 14.7 1.5 0.015 14.6 1.5 1.0 1 0 0 1 1 1 0 Ecdysteroid kinase Med8 PF10232.9 ETO22103.1 - 0.081 12.5 2.4 0.094 12.3 2.4 1.1 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 Syja_N PF02383.18 ETO22104.1 - 1.3e-71 241.6 2.2 2.6e-71 240.6 0.1 2.0 2 0 0 2 2 2 1 SacI homology domain RNA_pol_Rpc4 PF05132.14 ETO22104.1 - 0.0018 18.7 0.6 0.0034 17.8 0.6 1.5 1 0 0 1 1 1 1 RNA polymerase III RPC4 NARP1 PF12569.8 ETO22104.1 - 0.009 15.0 8.2 0.013 14.4 8.2 1.2 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 Rgp1 PF08737.10 ETO22104.1 - 0.049 12.8 3.2 0.067 12.4 3.2 1.2 1 0 0 1 1 1 0 Rgp1 CDC45 PF02724.14 ETO22104.1 - 0.05 11.9 14.8 0.083 11.2 14.8 1.3 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO22104.1 - 0.088 13.1 14.1 0.19 12.1 14.1 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RRN3 PF05327.11 ETO22104.1 - 0.095 11.2 9.0 0.13 10.8 9.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DDHD PF02862.17 ETO22104.1 - 0.13 12.4 0.8 0.19 11.9 0.8 1.4 1 0 0 1 1 1 0 DDHD domain DUF3530 PF12048.8 ETO22104.1 - 0.18 11.2 2.5 0.34 10.3 2.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) FYDLN_acid PF09538.10 ETO22104.1 - 0.19 12.4 17.6 0.42 11.3 17.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Nop14 PF04147.12 ETO22104.1 - 0.5 8.5 22.9 0.71 8.0 22.9 1.1 1 0 0 1 1 1 0 Nop14-like family DDRGK PF09756.9 ETO22104.1 - 0.56 9.8 24.7 1.1 8.9 24.7 1.4 1 0 0 1 1 1 0 DDRGK domain RR_TM4-6 PF06459.12 ETO22104.1 - 0.7 9.7 16.0 1.3 8.8 16.0 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BUD22 PF09073.10 ETO22104.1 - 1.1 8.6 22.9 2 7.7 22.9 1.3 1 0 0 1 1 1 0 BUD22 RNA_polI_A34 PF08208.11 ETO22104.1 - 1.1 9.3 18.4 2.6 8.1 18.4 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF913 PF06025.12 ETO22104.1 - 1.2 8.0 5.9 1.8 7.5 5.9 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Neur_chan_memb PF02932.16 ETO22104.1 - 1.4 8.9 3.6 2.1 8.3 3.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO22104.1 - 1.5 7.9 4.3 2.4 7.3 4.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PPL5 PF18168.1 ETO22104.1 - 1.9 7.7 10.5 2 7.7 9.1 1.7 2 0 0 2 2 2 0 Prim-pol family 5 SLC12 PF03522.15 ETO22104.1 - 3.8 6.4 11.6 6.4 5.7 11.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Cytomega_UL84 PF06284.11 ETO22104.1 - 4 5.8 8.4 6.1 5.2 8.4 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PTPRCAP PF15713.5 ETO22104.1 - 4.7 7.5 19.9 8.8 6.6 19.9 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CPSF100_C PF13299.6 ETO22104.1 - 5.8 7.1 12.3 11 6.2 10.6 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 ETO22104.1 - 7.3 5.2 11.8 11 4.7 11.8 1.2 1 0 0 1 1 1 0 Presenilin XRCC4 PF06632.12 ETO22105.1 - 1.5 7.6 7.4 1.6 7.5 0.2 2.2 2 0 0 2 2 2 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 STT3_PglB_C PF18527.1 ETO22109.1 - 0.0082 16.2 1.1 0.029 14.5 0.1 2.4 3 0 0 3 3 3 1 STT3/PglB C-terminal beta-barrel domain Cas_Cmr5 PF09701.10 ETO22109.1 - 0.063 13.6 0.1 0.17 12.2 0.1 1.7 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Cmr5) WXG100 PF06013.12 ETO22109.1 - 0.094 13.0 1.8 17 5.7 0.2 3.5 4 0 0 4 4 4 0 Proteins of 100 residues with WXG DUF2205 PF10224.9 ETO22109.1 - 4.2 7.4 17.3 0.37 10.8 0.3 3.9 2 2 2 4 4 4 0 Short coiled-coil protein TCTP PF00838.17 ETO22110.1 - 0.11 12.9 0.1 0.11 12.9 0.1 1.8 2 0 0 2 2 2 0 Translationally controlled tumour protein Ank_2 PF12796.7 ETO22112.1 - 6.6e-07 29.8 0.1 1e-05 26.0 0.0 2.4 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO22112.1 - 0.00026 21.3 0.1 1.4 9.5 0.0 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank_3 PF13606.6 ETO22112.1 - 0.0015 18.9 0.2 2.5 8.9 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat LktC PF06261.11 ETO22112.1 - 0.015 15.2 0.2 0.021 14.8 0.2 1.3 1 0 0 1 1 1 0 Actinobacillus actinomycetemcomitans leukotoxin activator LktC Ku_C PF03730.14 ETO22112.1 - 0.021 15.5 2.4 0.27 11.9 1.1 2.3 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm His_binding PF02098.16 ETO22112.1 - 0.06 13.4 0.3 0.11 12.5 0.1 1.5 1 1 0 1 1 1 0 Tick histamine binding protein DUF1786 PF08735.10 ETO22112.1 - 0.13 11.5 0.0 13 5.0 0.0 2.0 2 0 0 2 2 2 0 Putative pyruvate format-lyase activating enzyme (DUF1786) 7TM_GPCR_Srj PF10319.9 ETO22112.1 - 0.14 11.5 0.1 0.26 10.6 0.1 1.4 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srj Lentivirus_VIF PF05851.11 ETO22112.1 - 0.14 11.1 0.2 0.14 11.1 0.2 2.2 1 1 0 2 2 2 0 Lentivirus virion infectivity factor (VIF) DUF5310 PF17237.2 ETO22114.1 - 0.057 13.3 0.0 0.098 12.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5310) WD40 PF00400.32 ETO22115.1 - 1e-29 102.1 4.1 2.2e-10 41.0 0.0 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22115.1 - 2.4e-12 47.0 1.0 2.7e-05 24.4 0.1 4.4 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO22115.1 - 5.2e-10 39.5 0.6 0.00015 21.7 0.3 2.9 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO22115.1 - 9.5e-06 25.1 1.1 4.5e-05 22.9 0.1 2.3 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO22115.1 - 2e-05 23.4 3.0 0.24 10.0 0.0 3.2 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO22115.1 - 0.00011 21.4 0.6 0.7 8.8 0.0 3.0 1 1 1 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO22115.1 - 0.00029 19.5 0.1 0.001 17.7 0.0 1.9 1 1 0 2 2 2 1 Cytochrome D1 heme domain Str_synth PF03088.16 ETO22115.1 - 0.00035 20.6 0.0 4.1 7.6 0.0 3.6 3 0 0 3 3 3 2 Strictosidine synthase Csm1_B PF18211.1 ETO22115.1 - 0.083 12.7 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Csm1 subunit domain B ArlS_N PF18719.1 ETO22115.1 - 0.26 11.5 3.2 19 5.5 0.1 3.6 2 1 3 5 5 5 0 ArlS sensor domain Ku PF02735.16 ETO22116.1 - 1.2e-12 48.0 0.0 1.8e-12 47.4 0.0 1.3 1 0 0 1 1 1 1 Ku70/Ku80 beta-barrel domain Ku_N PF03731.15 ETO22116.1 - 4.6e-12 46.1 0.9 6.1e-12 45.7 0.9 1.1 1 0 0 1 1 1 1 Ku70/Ku80 N-terminal alpha/beta domain Fringe PF02434.16 ETO22116.1 - 0.14 11.5 2.3 0.29 10.5 1.3 1.7 1 1 0 2 2 2 0 Fringe-like TPR_12 PF13424.6 ETO22117.1 - 6.7e-55 183.3 10.6 6.4e-19 68.0 0.3 5.4 2 2 1 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22117.1 - 4.8e-47 156.6 0.0 4.5e-10 39.1 0.0 7.6 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22117.1 - 1.2e-37 126.2 44.2 2.3e-09 36.7 0.7 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22117.1 - 2.3e-35 118.0 13.1 5.3e-09 35.5 0.0 8.7 8 1 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22117.1 - 4.4e-30 101.3 36.2 1.9e-06 27.5 0.3 8.5 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22117.1 - 8.4e-26 88.0 44.9 9.6e-09 34.8 0.6 8.6 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22117.1 - 1.9e-13 49.8 5.4 0.011 16.0 0.1 7.3 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22117.1 - 3.1e-13 49.3 0.4 1.6 9.8 0.0 7.2 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22117.1 - 7.6e-12 45.7 0.2 0.0013 19.3 0.0 5.4 2 2 3 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22117.1 - 1.3e-10 41.2 15.4 0.46 11.2 0.0 7.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_3 PF07720.12 ETO22117.1 - 2.1e-09 37.2 33.0 0.045 13.8 0.4 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22117.1 - 6.6e-09 35.3 33.8 0.016 14.8 0.4 8.5 7 1 1 8 8 8 5 TPR repeat TPR_MalT PF17874.1 ETO22117.1 - 9.6e-08 31.8 0.0 0.00014 21.4 0.0 2.5 2 0 0 2 2 2 2 MalT-like TPR region ANAPC3 PF12895.7 ETO22117.1 - 3.1e-07 30.5 7.5 0.057 13.7 0.2 3.9 2 1 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO22117.1 - 6e-05 23.0 17.8 12 6.0 0.7 7.3 7 0 0 7 7 7 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO22117.1 - 6.4e-05 22.3 6.8 8.7 5.9 0.2 5.9 6 0 0 6 6 6 0 SHNi-TPR Sel1 PF08238.12 ETO22117.1 - 0.00025 21.6 11.3 0.63 10.8 0.2 5.2 4 1 0 4 4 4 1 Sel1 repeat DUF5113 PF17140.4 ETO22117.1 - 0.00084 19.2 19.0 0.7 9.7 0.4 6.2 6 0 0 6 6 6 3 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO22117.1 - 0.002 18.6 6.5 3.6 8.2 0.2 5.1 4 2 1 5 5 5 2 Tetratricopeptide repeat PPR PF01535.20 ETO22117.1 - 0.0023 18.1 7.0 0.036 14.3 0.1 4.9 7 0 0 7 7 4 1 PPR repeat DUF4810 PF16068.5 ETO22117.1 - 0.029 14.9 7.1 2.1 8.9 0.0 4.8 5 0 0 5 5 4 0 Domain of unknown function (DUF4810) PPR_2 PF13041.6 ETO22117.1 - 5.4 7.3 7.8 32 4.8 0.1 5.0 6 0 0 6 6 5 0 PPR repeat family EMP24_GP25L PF01105.24 ETO22118.1 - 0.015 15.2 0.5 0.037 14.0 0.2 1.9 2 1 0 2 2 2 0 emp24/gp25L/p24 family/GOLD CENP-B_dimeris PF09026.10 ETO22118.1 - 0.067 13.6 6.2 0.21 12.0 6.2 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pro-kuma_activ PF09286.11 ETO22120.1 - 0.098 13.0 0.3 0.49 10.7 0.3 2.1 2 0 0 2 2 2 0 Pro-kumamolisin, activation domain ACOX PF01756.19 ETO22121.1 - 0.062 12.9 2.1 0.17 11.5 0.3 2.1 2 0 0 2 2 2 0 Acyl-CoA oxidase DUF3488 PF11992.8 ETO22121.1 - 0.6 9.0 11.9 0.019 13.9 3.1 2.5 2 1 1 3 3 3 0 Domain of unknown function (DUF3488) Nop14 PF04147.12 ETO22123.1 - 0.00031 19.1 7.5 0.00034 19.0 7.5 1.0 1 0 0 1 1 1 1 Nop14-like family RRN3 PF05327.11 ETO22123.1 - 0.0014 17.3 3.0 0.0016 17.1 3.0 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Pox_RNA_Pol_19 PF05320.12 ETO22123.1 - 0.002 18.2 4.8 0.0028 17.7 4.8 1.1 1 0 0 1 1 1 1 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Macoilin PF09726.9 ETO22123.1 - 0.0082 14.8 0.8 0.01 14.5 0.8 1.2 1 0 0 1 1 1 1 Macoilin family CDC45 PF02724.14 ETO22123.1 - 0.019 13.3 7.4 0.021 13.1 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO22123.1 - 0.035 12.2 6.9 0.041 12.0 6.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PI3K_1B_p101 PF10486.9 ETO22123.1 - 0.036 11.9 5.9 0.036 11.9 5.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF2052 PF09747.9 ETO22123.1 - 0.087 12.9 12.3 0.11 12.6 12.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) PTPRCAP PF15713.5 ETO22123.1 - 0.091 13.0 10.1 0.12 12.6 10.1 1.2 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated BSP_II PF05432.11 ETO22123.1 - 0.19 11.4 16.3 0.35 10.5 16.3 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Radial_spoke PF04712.12 ETO22123.1 - 0.2 10.6 10.4 0.25 10.3 10.4 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein SDA1 PF05285.12 ETO22123.1 - 0.21 11.0 13.6 0.29 10.5 13.6 1.1 1 0 0 1 1 1 0 SDA1 Mpp10 PF04006.12 ETO22123.1 - 0.28 9.6 16.4 0.37 9.2 16.4 1.1 1 0 0 1 1 1 0 Mpp10 protein Folliculin PF11704.8 ETO22123.1 - 0.39 10.6 3.8 0.65 9.9 3.8 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Sigma70_ner PF04546.13 ETO22123.1 - 0.49 10.3 10.5 0.65 9.8 10.5 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.6 ETO22123.1 - 0.5 10.8 5.7 1.1 9.7 5.7 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DNA_pol_phi PF04931.13 ETO22123.1 - 0.57 8.2 15.5 0.72 7.9 15.5 1.1 1 0 0 1 1 1 0 DNA polymerase phi Tim54 PF11711.8 ETO22123.1 - 0.58 8.9 5.3 0.8 8.4 5.3 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Astro_capsid_p PF12226.8 ETO22123.1 - 0.62 9.2 8.6 0.84 8.7 8.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CAC1F_C PF16885.5 ETO22123.1 - 0.75 9.4 7.3 0.93 9.1 7.3 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CPSF100_C PF13299.6 ETO22123.1 - 0.87 9.8 8.2 1.3 9.2 8.2 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CENP-B_dimeris PF09026.10 ETO22123.1 - 1.1 9.7 13.7 2.3 8.6 13.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RR_TM4-6 PF06459.12 ETO22123.1 - 1.3 8.8 10.6 2 8.2 10.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TFIIF_alpha PF05793.12 ETO22123.1 - 1.8 7.1 16.0 2.5 6.6 16.0 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TRAP_alpha PF03896.16 ETO22123.1 - 2.1 7.5 9.1 3.4 6.8 9.1 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2012 PF09430.10 ETO22124.1 - 0.051 13.7 0.8 0.76 9.9 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2012) SR-25 PF10500.9 ETO22124.1 - 8.4 5.9 16.6 14 5.2 16.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Hydrolase PF00702.26 ETO22126.1 - 0.00022 21.6 0.2 0.00029 21.2 0.2 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETO22126.1 - 0.006 16.3 0.3 0.014 15.2 0.1 1.4 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase PhoLip_ATPase_C PF16212.5 ETO22127.1 - 7e-29 101.3 33.8 1.2e-26 94.0 15.1 2.0 1 1 1 2 2 2 2 Phospholipid-translocating P-type ATPase C-terminal NTPase_I-T PF01931.18 ETO22128.1 - 2.6e-14 53.4 0.0 3.4e-14 52.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function DUF84 Cation_ATPase PF13246.6 ETO22129.1 - 3.5e-12 46.3 0.0 1.2e-11 44.5 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO22129.1 - 2.6e-07 31.2 0.2 0.00015 22.1 0.1 3.2 2 1 1 3 3 3 2 haloacid dehalogenase-like hydrolase ApoC-I PF04691.12 ETO22130.1 - 1.9 8.5 6.4 0.41 10.6 0.5 2.9 3 0 0 3 3 3 0 Apolipoprotein C-I (ApoC-1) Tox-HNH-HHH PF15637.6 ETO22131.1 - 0.02 15.0 0.4 0.05 13.8 0.0 1.7 2 0 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Secretin PF00263.21 ETO22131.1 - 0.048 13.3 0.0 0.063 12.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial type II and III secretion system protein Lipl32 PF12103.8 ETO22131.1 - 0.09 12.4 0.1 0.098 12.3 0.1 1.2 1 0 0 1 1 1 0 Surface lipoprotein of Spirochaetales order Consortin_C PF15281.6 ETO22132.1 - 0.015 15.3 0.0 0.049 13.6 0.0 1.9 1 0 0 1 1 1 0 Consortin C-terminus Zip PF02535.22 ETO22132.1 - 0.016 14.5 0.4 0.028 13.6 0.3 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter CcmH PF03918.14 ETO22132.1 - 0.085 12.1 0.7 0.97 8.7 0.1 2.7 1 1 1 2 2 2 0 Cytochrome C biogenesis protein Peptidase_S49_N PF08496.10 ETO22132.1 - 9.4 6.3 10.3 3.7 7.6 1.4 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal FLYWCH PF04500.16 ETO22136.1 - 1.1 9.5 6.6 1.8 8.7 4.3 2.6 2 1 0 2 2 2 0 FLYWCH zinc finger domain AP3D1 PF06375.11 ETO22136.1 - 1.3 9.2 5.5 2.3 8.4 5.5 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF5392 PF17370.2 ETO22138.1 - 0.068 13.2 0.3 0.1 12.7 0.3 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5392) Kinesin PF00225.23 ETO22139.1 - 7.8e-08 31.6 0.6 4.2e-07 29.2 0.1 2.2 2 0 0 2 2 2 1 Kinesin motor domain FliJ PF02050.16 ETO22139.1 - 0.00072 19.8 1.8 0.00072 19.8 1.8 2.0 2 0 0 2 2 2 1 Flagellar FliJ protein Kinesin_assoc PF16183.5 ETO22139.1 - 0.0067 16.6 0.4 0.0067 16.6 0.4 2.5 2 1 0 2 2 2 1 Kinesin-associated UPF0242 PF06785.11 ETO22139.1 - 0.018 15.2 1.8 0.018 15.2 1.8 2.3 2 1 0 2 2 1 0 Uncharacterised protein family (UPF0242) N-terminus SlyX PF04102.12 ETO22139.1 - 0.036 14.7 2.1 0.036 14.7 2.1 2.2 2 0 0 2 2 1 0 SlyX DUF2508 PF10704.9 ETO22139.1 - 0.037 14.2 3.4 0.14 12.3 3.4 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2508) EMP24_GP25L PF01105.24 ETO22139.1 - 0.08 12.9 1.0 0.27 11.1 1.0 1.9 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF948 PF06103.11 ETO22139.1 - 0.088 13.1 0.5 0.31 11.3 0.5 2.0 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) HSP20 PF00011.21 ETO22139.1 - 0.23 11.6 0.1 0.23 11.6 0.1 2.8 3 0 0 3 3 3 0 Hsp20/alpha crystallin family DUF1664 PF07889.12 ETO22139.1 - 0.5 10.4 7.4 0.17 11.9 1.5 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF3213 PF11491.8 ETO22139.1 - 0.71 10.1 5.1 0.91 9.7 0.1 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3213) DUF745 PF05335.13 ETO22139.1 - 0.75 9.5 8.0 0.032 13.9 1.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF745) PIEZO PF15917.5 ETO22139.1 - 0.98 8.9 6.8 2.2 7.7 6.8 1.7 1 1 0 1 1 1 0 Piezo DUF1043 PF06295.12 ETO22139.1 - 1.5 8.8 10.4 0.36 10.8 2.8 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) XhlA PF10779.9 ETO22139.1 - 1.9 8.8 6.6 0.9 9.8 2.0 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Mt_ATP-synt_D PF05873.12 ETO22139.1 - 2.1 8.2 14.5 0.033 14.0 2.9 2.8 2 1 0 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) Fungal_TACC PF12709.7 ETO22139.1 - 3.1 8.3 10.4 0.68 10.4 5.8 2.3 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins YkuI_C PF10388.9 ETO22139.1 - 3.2 7.5 6.4 1.1 9.1 3.6 1.6 2 0 0 2 2 1 0 EAL-domain associated signalling protein domain YabA PF06156.13 ETO22139.1 - 4.8 7.9 13.2 0.54 10.9 4.2 3.2 3 0 0 3 3 3 0 Initiation control protein YabA DUF87 PF01935.17 ETO22139.1 - 5.5 7.0 7.9 1.4 9.0 3.0 2.4 1 1 2 3 3 3 0 Helicase HerA, central domain WD40 PF00400.32 ETO22140.1 - 4.9e-16 58.8 17.3 2.9e-05 24.7 0.2 5.4 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22140.1 - 9.9e-11 41.8 0.7 0.004 17.4 0.0 4.3 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO22140.1 - 0.0024 17.3 0.1 1.2 8.4 0.0 2.7 2 1 0 2 2 2 2 WD40-like domain DUF4709 PF15821.5 ETO22140.1 - 0.13 12.6 0.1 0.26 11.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4709) DUF5394 PF17372.2 ETO22140.1 - 0.15 11.6 0.1 0.34 10.4 0.1 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5394) DUF4834 PF16118.5 ETO22141.1 - 0.087 13.8 0.5 0.087 13.8 0.5 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) TMCO5 PF14992.6 ETO22142.1 - 0.14 11.7 0.2 0.27 10.8 0.2 1.4 1 0 0 1 1 1 0 TMCO5 family SIT PF15330.6 ETO22142.1 - 0.29 11.6 0.1 0.29 11.6 0.1 2.4 1 1 1 2 2 2 0 SHP2-interacting transmembrane adaptor protein, SIT DUF1451 PF07295.11 ETO22143.1 - 0.052 13.6 0.0 0.071 13.1 0.0 1.3 1 0 0 1 1 1 0 Zinc-ribbon containing domain Dapper PF15268.6 ETO22145.1 - 3.2 6.5 16.1 5.1 5.8 16.1 1.3 1 0 0 1 1 1 0 Dapper Nop14 PF04147.12 ETO22145.1 - 5.8 5.0 29.9 0.31 9.2 25.0 1.4 2 0 0 2 2 2 0 Nop14-like family Pannexin_like PF12534.8 ETO22145.1 - 8.1 5.4 11.0 3.2 6.8 5.6 2.5 2 1 0 2 2 2 0 Pannexin-like TM region of LRRC8 FANCM-MHF_bd PF16783.5 ETO22147.1 - 0.67 10.0 5.2 0.33 11.0 2.7 1.7 2 1 0 2 2 2 0 FANCM to MHF binding domain Voltage_CLC PF00654.20 ETO22149.1 - 6.1e-25 88.2 2.3 7.1e-25 88.0 2.3 1.0 1 0 0 1 1 1 1 Voltage gated chloride channel zf-LITAF-like PF10601.9 ETO22149.1 - 0.11 12.8 0.6 0.11 12.8 0.6 3.3 4 0 0 4 4 4 0 LITAF-like zinc ribbon domain TauE PF01925.19 ETO22149.1 - 0.13 11.8 5.9 3.4 7.2 6.4 2.2 1 1 1 2 2 2 0 Sulfite exporter TauE/SafE 5TM-5TMR_LYT PF07694.12 ETO22149.1 - 0.17 11.4 4.5 0.32 10.5 1.5 2.2 2 0 0 2 2 2 0 5TMR of 5TMR-LYT PDZ_6 PF17820.1 ETO22150.1 - 7.1e-07 29.0 0.1 1.5e-06 27.9 0.1 1.6 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ETO22150.1 - 8e-07 29.3 0.0 1.1e-06 28.8 0.0 1.2 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO22150.1 - 0.00019 21.7 0.0 0.00058 20.1 0.0 1.7 2 0 0 2 2 2 1 PDZ domain PH PF00169.29 ETO22151.1 - 6e-07 29.9 0.1 1.1e-06 29.1 0.0 1.5 2 0 0 2 2 2 1 PH domain PH_13 PF16652.5 ETO22151.1 - 0.00042 20.2 4.0 0.14 12.0 0.5 2.2 1 1 1 2 2 2 2 Pleckstrin homology domain PH_16 PF17838.1 ETO22151.1 - 0.00085 19.2 0.0 0.0015 18.4 0.0 1.4 1 0 0 1 1 1 1 PH domain Lipase_GDSL_3 PF14606.6 ETO22151.1 - 0.0053 16.9 0.1 0.0075 16.4 0.1 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family LZ3wCH PF18517.1 ETO22151.1 - 0.15 12.2 0.9 0.38 10.9 0.9 1.7 1 0 0 1 1 1 0 Leucine zipper with capping helix domain Apo-CIII PF05778.12 ETO22151.1 - 0.19 11.4 0.5 0.55 9.9 0.5 1.7 1 1 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) Menin PF05053.13 ETO22153.1 - 0.036 12.4 2.7 0.037 12.4 2.7 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO22153.1 - 0.066 13.8 6.6 0.086 13.4 6.6 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain PEARLI-4 PF05278.12 ETO22153.1 - 0.1 12.2 1.0 0.13 11.8 1.0 1.3 1 0 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) Orf78 PF06024.12 ETO22153.1 - 0.63 10.4 4.2 0.91 9.9 4.2 1.4 1 0 0 1 1 1 0 Orf78 (ac78) RP-C_C PF11800.8 ETO22153.1 - 1.2 9.2 3.8 1.6 8.8 3.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region PT PF04886.12 ETO22154.1 - 4.5e-28 96.5 149.8 5.9e-09 35.3 22.0 10.7 4 3 4 8 8 8 6 PT repeat MLANA PF14991.6 ETO22154.1 - 0.0028 17.9 0.1 0.0077 16.5 0.0 1.8 2 0 0 2 2 2 1 Protein melan-A DUF5305 PF17231.2 ETO22154.1 - 0.91 8.9 9.5 0.031 13.7 2.6 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5305) HRG PF16954.5 ETO22155.1 - 0.051 14.0 0.9 0.051 14.0 0.9 2.5 2 2 0 2 2 2 0 Haem-transporter, endosomal/lysosomal, haem-responsive gene Macoilin PF09726.9 ETO22155.1 - 9.8 4.6 6.4 13 4.2 6.3 1.3 1 1 0 1 1 1 0 Macoilin family HMMR_N PF15905.5 ETO22156.1 - 0.00037 20.1 12.7 0.00058 19.4 12.7 1.2 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal zf-CCHC_3 PF13917.6 ETO22156.1 - 0.027 14.5 1.2 0.065 13.2 1.2 1.6 1 0 0 1 1 1 0 Zinc knuckle Jnk-SapK_ap_N PF09744.9 ETO22156.1 - 0.14 12.4 12.0 0.25 11.6 12.0 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Phage_GP20 PF06810.11 ETO22156.1 - 0.18 11.6 4.8 0.41 10.4 4.8 1.6 1 0 0 1 1 1 0 Phage minor structural protein GP20 DUF4407 PF14362.6 ETO22156.1 - 0.25 10.6 2.4 0.39 10.0 2.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Striatin PF08232.12 ETO22156.1 - 1.1 9.8 21.7 0.048 14.2 8.2 2.8 2 1 1 3 3 3 0 Striatin family PRKG1_interact PF15898.5 ETO22156.1 - 4.4 8.3 15.8 3.4 8.6 13.1 2.2 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 ETO22156.1 - 4.9 7.0 5.9 32 4.4 0.1 2.5 1 1 1 2 2 2 0 Septum formation initiator UPF0449 PF15136.6 ETO22156.1 - 7.9 7.0 7.9 6.2 7.4 4.5 2.5 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 Pkinase PF00069.25 ETO22157.1 - 1.7e-13 50.5 0.0 2.8e-13 49.9 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO22157.1 - 1e-08 34.4 0.0 1.3e-08 34.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ETO22157.1 - 0.0049 16.2 0.0 0.0065 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO22157.1 - 0.024 14.5 1.3 0.045 13.7 0.1 2.0 3 0 0 3 3 3 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO22157.1 - 0.046 13.0 0.0 0.073 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Pox_ser-thr_kin PF05445.11 ETO22157.1 - 0.064 12.2 0.0 0.088 11.8 0.0 1.1 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kdo PF06293.14 ETO22157.1 - 0.067 12.5 0.1 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3677 PF12432.8 ETO22159.1 - 0.01 16.2 0.6 1.9 8.9 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3677) WD40 PF00400.32 ETO22160.1 - 1.7e-10 41.3 4.6 0.0004 21.1 0.1 3.9 3 1 0 3 3 3 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO22160.1 - 0.0031 16.9 0.7 0.1 11.9 0.3 2.0 1 1 1 2 2 2 2 WD40-like domain HARP PF07443.13 ETO22160.1 - 0.011 15.3 0.2 3.6 7.3 0.0 2.3 2 0 0 2 2 2 0 HepA-related protein (HARP) Nup160 PF11715.8 ETO22160.1 - 0.019 13.7 0.2 0.54 8.8 0.2 2.0 1 1 0 1 1 1 0 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO22160.1 - 0.037 14.3 0.1 0.89 9.9 0.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO22160.1 - 0.044 13.8 0.9 0.44 10.6 0.6 2.4 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Kelch_4 PF13418.6 ETO22161.1 - 1.8e-07 31.1 0.4 0.03 14.3 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO22161.1 - 4.4e-06 26.2 1.7 0.043 13.4 0.3 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO22161.1 - 0.00033 20.6 1.5 0.4 10.7 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO22161.1 - 0.0039 17.4 2.4 0.86 10.0 0.0 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO22161.1 - 0.0039 17.1 4.0 2.3 8.3 0.9 3.4 4 0 0 4 4 4 2 Kelch motif EZH2_N PF18601.1 ETO22161.1 - 0.035 14.4 0.4 0.33 11.3 0.1 2.6 2 0 0 2 2 2 0 EZH2 N-terminal domain Kelch_3 PF13415.6 ETO22161.1 - 0.052 13.8 0.2 28 5.2 0.0 3.7 4 0 0 4 4 4 0 Galactose oxidase, central domain 5_nucleotid PF05761.14 ETO22162.1 - 2.5e-57 194.8 0.4 3.2e-57 194.4 0.4 1.0 1 0 0 1 1 1 1 5' nucleotidase family Connexin PF00029.19 ETO22163.1 - 0.028 14.2 1.6 0.027 14.2 1.6 1.1 1 0 0 1 1 1 0 Connexin PPL5 PF18168.1 ETO22163.1 - 0.059 12.7 4.8 0.067 12.5 4.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 CDC45 PF02724.14 ETO22163.1 - 0.22 9.8 5.0 0.21 9.9 5.0 1.1 1 0 0 1 1 1 0 CDC45-like protein RPA43_OB PF17875.1 ETO22163.1 - 0.66 10.6 4.4 0.85 10.2 4.4 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I U3_snoRNA_assoc PF08297.11 ETO22163.1 - 0.68 10.7 11.6 1.1 10.1 11.6 1.6 1 1 0 1 1 1 0 U3 snoRNA associated FAM176 PF14851.6 ETO22163.1 - 1.4 8.6 5.5 1.5 8.5 5.5 1.2 1 0 0 1 1 1 0 FAM176 family Sec62 PF03839.16 ETO22163.1 - 2.8 7.4 6.5 2.7 7.5 6.5 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 PI3K_1B_p101 PF10486.9 ETO22165.1 - 0.0045 14.9 1.8 1.1 6.9 0.0 2.2 1 1 0 2 2 2 2 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sigma_reg_N PF13800.6 ETO22165.1 - 0.073 13.4 2.4 0.13 12.6 0.9 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal zf-LITAF-like PF10601.9 ETO22165.1 - 0.81 10.0 6.6 0.24 11.7 3.3 1.8 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain WD40 PF00400.32 ETO22166.1 - 2.9e-10 40.6 16.9 5.1e-09 36.6 3.9 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO22166.1 - 1.9e-05 25.3 6.1 1.9e-05 25.3 6.1 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger Nup160 PF11715.8 ETO22166.1 - 0.00031 19.5 0.2 0.00053 18.8 0.2 1.3 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO22166.1 - 0.014 15.6 0.0 0.035 14.4 0.0 1.6 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF4781 PF16013.5 ETO22166.1 - 0.47 9.2 4.5 0.73 8.6 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) TMEM237 PF15383.6 ETO22166.1 - 0.86 8.6 4.6 1.3 8.0 4.6 1.3 1 0 0 1 1 1 0 Transmembrane protein 237 UCH PF00443.29 ETO22167.1 - 5.5e-26 91.6 0.2 7e-26 91.3 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO22167.1 - 4.8e-15 56.0 5.9 6.8e-15 55.5 5.9 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase TPR_2 PF07719.17 ETO22168.1 - 1.3e-06 28.1 6.5 0.002 18.1 2.9 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO22168.1 - 2.9e-06 27.7 6.2 4.7e-06 27.0 6.2 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22168.1 - 3.7e-05 23.4 7.1 0.049 13.5 3.5 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22168.1 - 5.5e-05 23.1 6.6 0.079 13.2 2.6 2.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22168.1 - 0.0005 19.7 6.7 0.096 12.4 0.4 2.4 2 0 0 2 2 2 2 TPR repeat TPR_12 PF13424.6 ETO22168.1 - 0.0021 18.3 5.5 0.025 14.9 4.9 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat Coatomer_E PF04733.14 ETO22168.1 - 0.0039 16.7 0.5 0.0039 16.7 0.5 1.6 2 0 0 2 2 2 1 Coatomer epsilon subunit Syntaphilin PF15290.6 ETO22168.1 - 0.011 15.4 1.3 0.011 15.4 1.3 1.5 1 1 0 1 1 1 0 Golgi-localised syntaxin-1-binding clamp TPR_9 PF13371.6 ETO22168.1 - 0.034 14.3 0.7 0.058 13.5 0.7 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22168.1 - 0.049 14.3 4.1 0.09 13.4 4.0 1.5 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22168.1 - 0.072 13.0 1.7 1.1 9.3 0.2 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22168.1 - 0.082 13.0 2.5 7.3 6.9 0.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO22168.1 - 3.9 7.6 8.2 4.1 7.5 2.2 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22168.1 - 3.9 8.3 6.1 20 6.1 0.5 3.3 2 1 0 2 2 2 0 Tetratricopeptide repeat Prefoldin PF02996.17 ETO22168.1 - 4.5 7.2 11.4 0.38 10.7 1.3 2.7 3 0 0 3 3 3 0 Prefoldin subunit Sec15 PF04091.12 ETO22169.1 - 1.6e-36 126.3 0.8 3.2e-24 85.9 0.2 3.5 2 1 0 2 2 2 2 Exocyst complex subunit Sec15-like Allantoicase PF03561.15 ETO22170.1 - 0.00096 19.1 0.9 0.0022 18.0 0.9 1.6 1 0 0 1 1 1 1 Allantoicase repeat SH3-WW_linker PF16618.5 ETO22170.1 - 2.6 8.5 8.5 0.27 11.7 1.6 2.1 2 0 0 2 2 2 0 Linker region between SH3 and WW domains on ARHGAP12 Vps8 PF12816.7 ETO22171.1 - 2.6e-27 95.6 4.5 3.4e-27 95.2 3.7 1.7 1 1 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 AAA_lid_7 PF17867.1 ETO22171.1 - 0.2 11.8 1.1 4.4 7.6 0.1 3.0 3 0 0 3 3 3 0 Midasin AAA lid domain Iron_permease PF04120.12 ETO22172.1 - 0.12 12.1 2.9 1.3 8.8 0.0 2.5 2 1 0 2 2 2 0 Low affinity iron permease RTP1_C1 PF10363.9 ETO22172.1 - 0.57 10.4 3.8 1.6 8.9 0.1 2.9 2 2 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Clathrin PF00637.20 ETO22173.1 - 7.6e-07 29.1 2.4 1.2e-06 28.4 1.5 1.7 2 0 0 2 2 2 1 Region in Clathrin and VPS Prp18 PF02840.15 ETO22173.1 - 0.052 13.6 0.7 0.094 12.8 0.7 1.4 1 0 0 1 1 1 0 Prp18 domain TPR_14 PF13428.6 ETO22173.1 - 0.12 13.3 0.0 0.3 12.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF2408 PF10303.9 ETO22174.1 - 0.038 14.6 0.4 0.079 13.5 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) zf-C3HC4 PF00097.25 ETO22174.1 - 0.99 9.3 6.7 1.2 9.0 3.2 2.9 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO22174.1 - 4.5 7.6 6.9 1.8 8.9 3.5 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain CheX PF13690.6 ETO22175.1 - 0.19 11.9 0.8 0.38 11.0 0.8 1.5 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX E7 PF00527.18 ETO22175.1 - 0.35 11.1 6.7 8.1 6.7 3.3 2.8 2 0 0 2 2 2 0 E7 protein, Early protein Rtf2 PF04641.12 ETO22175.1 - 9.5 5.5 21.7 4.2 6.7 7.9 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger BNIP3 PF06553.12 ETO22176.1 - 0.029 14.0 0.1 0.035 13.8 0.1 1.1 1 0 0 1 1 1 0 BNIP3 TauE PF01925.19 ETO22177.1 - 0.027 14.1 3.3 0.037 13.7 0.1 2.1 2 1 0 2 2 2 0 Sulfite exporter TauE/SafE MFS_2 PF13347.6 ETO22177.1 - 0.034 12.7 0.1 0.034 12.7 0.1 2.5 3 0 0 3 3 3 0 MFS/sugar transport protein WBP-1 PF11669.8 ETO22177.1 - 1.2 9.8 11.7 7.3 7.3 1.6 3.5 2 1 0 2 2 2 0 WW domain-binding protein 1 FHIPEP PF00771.20 ETO22177.1 - 1.9 6.8 4.3 8.5 4.7 3.9 1.9 2 0 0 2 2 2 0 FHIPEP family PUCC PF03209.15 ETO22177.1 - 4 6.3 11.4 0.023 13.7 0.9 2.3 2 1 0 2 2 2 0 PUCC protein DUF4752 PF15944.5 ETO22177.1 - 4.4 7.4 7.7 0.97 9.5 1.8 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4752) UPF0139 PF03669.13 ETO22177.1 - 6.1 6.8 6.5 2.2 8.2 0.0 3.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) DUF2852 PF11014.8 ETO22177.1 - 8.4 6.6 13.3 2.1 8.5 3.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF2852) Kelch_1 PF01344.25 ETO22179.1 - 1.6e-09 37.2 2.7 0.00012 21.6 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO22179.1 - 9.9e-09 35.2 3.0 0.0011 19.2 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO22179.1 - 1.7e-07 31.1 2.8 0.00027 20.9 0.1 4.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO22179.1 - 5.1e-07 29.4 3.2 0.038 14.0 0.1 3.8 4 0 0 4 4 4 2 Kelch motif DUF4763 PF15960.5 ETO22179.1 - 0.01 15.1 0.4 0.014 14.7 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Nbs1_C PF08599.10 ETO22179.1 - 0.09 12.9 0.8 0.26 11.4 0.8 1.8 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 Kelch_5 PF13854.6 ETO22179.1 - 0.13 12.3 0.9 2.2 8.4 0.1 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO22179.1 - 0.13 12.6 0.4 4.4 7.7 0.0 2.8 2 1 0 2 2 2 0 Galactose oxidase, central domain Pkinase PF00069.25 ETO22180.1 - 5.6e-14 52.1 0.0 6.7e-14 51.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22180.1 - 9.9e-05 21.7 0.0 0.00013 21.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Band_3_cyto PF07565.13 ETO22181.1 - 1.5 8.6 6.0 2.1 8.1 6.0 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2353 PF09789.9 ETO22182.1 - 0.0046 16.4 32.8 0.0046 16.4 32.8 3.1 1 1 1 3 3 3 1 Uncharacterized coiled-coil protein (DUF2353) APG6_N PF17675.1 ETO22182.1 - 0.019 15.5 15.0 0.019 15.5 15.0 4.4 1 1 3 4 4 4 0 Apg6 coiled-coil region DUF1133 PF06576.11 ETO22182.1 - 0.78 9.1 7.5 0.38 10.1 1.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1133) DUF2937 PF11157.8 ETO22182.1 - 4 7.1 13.7 0.051 13.3 4.6 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2937) Anoctamin PF04547.12 ETO22183.1 - 3.4e-62 210.7 10.3 3.9e-62 210.6 10.3 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel HTH_57 PF18679.1 ETO22183.1 - 0.069 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 ThcOx helix turn helix domain Chorion_3 PF05387.11 ETO22184.1 - 2.3 7.8 4.5 4.3 6.9 4.5 1.4 1 0 0 1 1 1 0 Chorion family 3 P34-Arc PF04045.14 ETO22185.1 - 1.2e-20 74.2 0.4 1.7e-20 73.7 0.4 1.1 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc P34-Arc PF04045.14 ETO22186.1 - 8.4e-16 58.4 0.0 1.2e-15 57.8 0.0 1.2 1 0 0 1 1 1 1 Arp2/3 complex, 34 kD subunit p34-Arc FH2 PF02181.23 ETO22187.1 - 4.9e-07 29.2 2.6 4.9e-07 29.2 2.6 2.4 1 1 2 3 3 3 1 Formin Homology 2 Domain DUF883 PF05957.13 ETO22187.1 - 0.032 14.8 1.5 0.032 14.8 1.5 2.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF883) DivIC PF04977.15 ETO22187.1 - 0.15 11.8 0.2 0.15 11.8 0.2 3.4 3 0 0 3 3 3 0 Septum formation initiator Unstab_antitox PF09720.10 ETO22187.1 - 0.26 11.4 2.7 0.23 11.6 0.3 2.2 2 0 0 2 2 2 0 Putative addiction module component DUF4510 PF14971.6 ETO22187.1 - 0.7 10.2 8.8 0.44 10.9 4.5 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4510) PID_2 PF14719.6 ETO22187.1 - 2.9 7.7 8.3 0.43 10.4 1.2 2.2 1 1 1 2 2 2 0 Phosphotyrosine interaction domain (PTB/PID) Cas_DxTHG PF09455.10 ETO22190.1 - 0.19 11.3 7.4 0.24 11.0 7.4 1.1 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family WWE PF02825.20 ETO22191.1 - 0.054 14.1 0.7 0.054 14.1 0.7 2.2 2 1 0 2 2 2 0 WWE domain FAM176 PF14851.6 ETO22192.1 - 0.001 18.7 1.6 0.001 18.7 1.6 2.3 2 1 0 2 2 2 1 FAM176 family Astro_capsid_p PF12226.8 ETO22192.1 - 0.039 13.1 2.9 0.062 12.4 2.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Carbam_trans_C PF16861.5 ETO22192.1 - 0.05 13.2 0.3 0.091 12.3 0.3 1.3 1 0 0 1 1 1 0 Carbamoyltransferase C-terminus Sin_N PF04801.13 ETO22192.1 - 0.072 12.3 5.6 0.11 11.7 5.6 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region OAD_gamma PF04277.13 ETO22192.1 - 0.1 13.2 0.1 0.1 13.2 0.1 2.7 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain YABBY PF04690.13 ETO22192.1 - 2.2 8.9 6.0 0.16 12.5 0.9 1.7 2 0 0 2 2 2 0 YABBY protein DUF2122 PF09895.9 ETO22192.1 - 4.3 7.8 5.7 11 6.5 5.6 1.7 1 1 0 1 1 1 0 RecB-family nuclease (DUF2122) PTPRCAP PF15713.5 ETO22192.1 - 9.7 6.5 10.1 22 5.3 10.1 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4381 PF14316.6 ETO22193.1 - 0.00042 20.6 0.1 0.00066 19.9 0.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) DUF2868 PF11067.8 ETO22193.1 - 0.009 15.6 0.0 0.013 15.1 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2868) Pox_EPC_I2-L1 PF12575.8 ETO22193.1 - 0.081 13.2 0.2 0.16 12.2 0.2 1.4 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 SKG6 PF08693.10 ETO22193.1 - 0.6 9.6 3.4 1.6 8.2 3.4 1.7 1 0 0 1 1 1 0 Transmembrane alpha-helix domain EMP24_GP25L PF01105.24 ETO22195.1 - 2.5e-25 89.5 0.0 3e-25 89.2 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SdrD_B PF17210.3 ETO22195.1 - 0.027 14.7 0.1 0.042 14.1 0.1 1.3 1 0 0 1 1 1 0 SdrD B-like domain Nop14 PF04147.12 ETO22197.1 - 0.011 14.0 17.5 0.014 13.7 17.5 1.0 1 0 0 1 1 1 0 Nop14-like family GNAT_acetyltr_2 PF13718.6 ETO22197.1 - 0.13 11.7 5.0 0.18 11.2 5.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 MMM1 PF10296.9 ETO22197.1 - 0.16 11.0 4.3 0.18 10.8 4.3 1.2 1 0 0 1 1 1 0 Maintenance of mitochondrial morphology protein 1 RRN3 PF05327.11 ETO22197.1 - 0.39 9.2 13.0 0.47 8.9 13.0 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ULD PF16534.5 ETO22197.1 - 0.6 10.2 4.0 5.5 7.1 4.0 2.6 2 1 0 2 2 2 0 Ubiquitin-like oligomerisation domain of SATB DUF2457 PF10446.9 ETO22197.1 - 0.62 9.1 17.9 0.68 9.0 17.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) FAM60A PF15396.6 ETO22197.1 - 0.71 9.8 6.7 0.8 9.7 6.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Mpp10 PF04006.12 ETO22197.1 - 0.93 7.9 25.3 1.2 7.5 25.3 1.0 1 0 0 1 1 1 0 Mpp10 protein SLC12 PF03522.15 ETO22197.1 - 1.2 8.1 11.7 1.5 7.8 11.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO22197.1 - 1.5 7.0 13.5 1.8 6.7 13.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO22197.1 - 2.4 6.4 8.9 3 6.1 8.9 1.1 1 0 0 1 1 1 0 Menin Piwi PF02171.17 ETO22198.1 - 5.8e-17 61.9 0.0 3.2e-10 39.7 0.0 2.3 2 0 0 2 2 2 2 Piwi domain Ribosomal_L6e PF01159.19 ETO22199.1 - 0.031 14.8 4.6 3.6 8.1 3.8 2.1 2 0 0 2 2 2 0 Ribosomal protein L6e UQ_con PF00179.26 ETO22201.1 - 1.2e-17 63.9 0.2 2.4e-17 62.9 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme PDZ PF00595.24 ETO22202.1 - 0.00013 22.2 0.0 0.00021 21.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Cylicin_N PF15241.6 ETO22202.1 - 0.024 14.7 4.2 0.042 14.0 4.2 1.4 1 0 0 1 1 1 0 Cylicin N-terminus TbpB_B_D PF01298.18 ETO22202.1 - 0.12 12.8 2.2 0.2 12.0 2.0 1.6 1 1 0 1 1 1 0 C-lobe and N-lobe beta barrels of Tf-binding protein B PDZ_6 PF17820.1 ETO22202.1 - 0.13 12.2 0.0 0.19 11.6 0.0 1.3 1 0 0 1 1 1 0 PDZ domain AP3D1 PF06375.11 ETO22202.1 - 0.9 9.8 12.5 0.15 12.3 6.9 2.1 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 Sas10_Utp3 PF04000.15 ETO22206.1 - 1.3e-07 32.1 3.8 7.9e-07 29.6 0.0 3.0 1 1 1 2 2 2 1 Sas10/Utp3/C1D family MukF_C PF17193.4 ETO22206.1 - 0.12 12.5 0.9 0.24 11.5 0.3 1.7 1 1 1 2 2 2 0 MukF C-terminal domain Aa_trans PF01490.18 ETO22207.1 - 1e-55 189.2 34.9 1.5e-55 188.6 34.9 1.3 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ETO22207.1 - 0.00038 19.6 9.9 0.00038 19.6 9.9 2.3 2 1 0 2 2 2 1 Tryptophan/tyrosine permease family SAM_1 PF00536.30 ETO22208.1 - 0.00022 21.6 0.2 0.00022 21.6 0.2 1.8 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO22208.1 - 0.015 15.4 0.1 0.026 14.6 0.1 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2785 PF10978.8 ETO22208.1 - 0.016 15.0 0.6 0.021 14.6 0.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2785) Glyco_transf_25 PF01755.17 ETO22211.1 - 0.00041 20.3 3.4 0.062 13.2 0.1 2.8 3 0 0 3 3 3 2 Glycosyltransferase family 25 (LPS biosynthesis protein) RabGAP-TBC PF00566.18 ETO22213.1 - 4.6e-07 29.7 0.2 5.7e-07 29.4 0.2 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Glyco_hydro_47 PF01532.20 ETO22214.1 - 1.5e-45 155.9 0.7 1.8e-45 155.7 0.7 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 WD40 PF00400.32 ETO22216.1 - 6.2e-38 128.1 7.0 6.5e-12 45.8 0.5 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22216.1 - 1.9e-11 44.1 0.9 0.00071 19.8 0.1 3.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22216.1 - 5.9e-07 28.8 0.1 1 8.2 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO22216.1 - 5.5e-05 23.0 0.0 2.5 8.1 0.0 3.4 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO22216.1 - 0.00025 21.0 0.0 0.12 12.3 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO22216.1 - 0.002 16.8 1.4 1.2 7.7 0.1 3.2 1 1 3 4 4 4 2 Nucleoporin Nup120/160 DUF4875 PF16175.5 ETO22216.1 - 0.035 14.2 0.0 4.7 7.4 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4875) Proteasome_A_N PF10584.9 ETO22216.1 - 0.051 13.3 0.1 11 5.9 0.0 2.6 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO22217.1 - 1.4e-09 38.4 0.0 1.6e-06 28.7 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat PAP_RNA-bind PF04926.15 ETO22217.1 - 0.032 13.9 1.7 0.043 13.4 1.7 1.1 1 0 0 1 1 1 0 Poly(A) polymerase predicted RNA binding domain PD40 PF07676.12 ETO22217.1 - 0.086 12.8 0.0 0.97 9.5 0.0 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat DUF1980 PF09323.10 ETO22217.1 - 0.093 12.6 2.6 0.14 12.1 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Pyrophosphatase PF00719.19 ETO22218.1 - 1.2e-46 158.5 0.0 1.4e-46 158.3 0.0 1.0 1 0 0 1 1 1 1 Inorganic pyrophosphatase Actin PF00022.19 ETO22220.1 - 3.1e-140 467.4 0.0 1.3e-139 465.3 0.0 1.7 1 1 0 1 1 1 1 Actin AJAP1_PANP_C PF15298.6 ETO22221.1 - 0.21 11.8 11.4 0.39 10.9 11.4 1.4 1 0 0 1 1 1 0 AJAP1/PANP C-terminus DUF3439 PF11921.8 ETO22221.1 - 0.24 11.4 8.5 5 7.1 6.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO22221.1 - 1.9 6.4 9.8 3.3 5.6 9.8 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein LIN37 PF15306.6 ETO22221.1 - 3.2 8.0 7.7 1.1 9.4 3.8 2.1 2 0 0 2 2 2 0 LIN37 DUF966 PF06136.13 ETO22221.1 - 5.8 6.5 13.6 0.82 9.3 7.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF966) B56 PF01603.20 ETO22222.1 - 2.6e-69 234.2 1.4 3.3e-69 233.9 1.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Telomere_reg-2 PF10193.9 ETO22222.1 - 0.062 13.7 0.0 0.32 11.4 0.0 2.1 1 1 1 2 2 2 0 Telomere length regulation protein GIY-YIG PF01541.24 ETO22224.1 - 1.9e-17 63.3 0.6 6.4e-17 61.6 0.4 2.1 1 1 0 1 1 1 1 GIY-YIG catalytic domain DUF5594 PF18057.1 ETO22227.1 - 0.1 12.4 0.1 0.17 11.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5594) CENP-B_dimeris PF09026.10 ETO22227.1 - 0.16 12.4 5.6 0.48 10.8 5.6 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BSP_II PF05432.11 ETO22227.1 - 0.24 11.0 17.4 0.39 10.4 17.4 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) PRIMA1 PF16101.5 ETO22227.1 - 5.6 7.0 7.8 9.9 6.2 7.8 1.4 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 YolD PF08863.10 ETO22227.1 - 6.1 7.0 10.5 12 6.0 0.5 2.5 2 0 0 2 2 2 0 YolD-like protein Pox_Ag35 PF03286.14 ETO22227.1 - 8.5 6.1 12.9 1.2 8.8 8.5 1.8 1 1 1 2 2 2 0 Pox virus Ag35 surface protein DUF3482 PF11981.8 ETO22228.1 - 0.21 10.9 0.0 0.21 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3482) DUF3245 PF11595.8 ETO22228.1 - 3.3 8.2 22.9 3.5 8.1 0.6 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3245) ELK PF03789.13 ETO22231.1 - 0.0013 18.7 0.7 0.15 12.2 0.1 2.5 2 0 0 2 2 2 2 ELK domain Sulfatase PF00884.23 ETO22232.1 - 3.5e-09 36.5 0.3 9e-09 35.1 0.0 1.7 2 0 0 2 2 2 1 Sulfatase Sulfatase_C PF14707.6 ETO22232.1 - 0.015 16.0 2.0 0.069 13.9 2.0 2.0 1 1 0 1 1 1 0 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 ETO22232.1 - 0.085 12.4 0.0 0.12 12.0 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DHC_N1 PF08385.12 ETO22233.1 - 8.8e-27 94.0 1.2 1.1e-26 93.6 1.2 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Herpes_glycop_D PF01537.17 ETO22233.1 - 0.036 14.2 0.4 0.064 13.4 0.4 1.3 1 0 0 1 1 1 0 Herpesvirus glycoprotein D/GG/GX domain Spt20 PF12090.8 ETO22235.1 - 0.0031 17.2 1.4 0.0031 17.2 1.4 3.2 4 0 0 4 4 4 1 Spt20 family zf-C2H2 PF00096.26 ETO22235.1 - 0.0065 16.9 6.7 0.021 15.2 0.9 3.1 2 0 0 2 2 2 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO22235.1 - 0.013 16.3 0.4 0.013 16.3 0.4 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger zf-Di19 PF05605.12 ETO22235.1 - 0.032 14.5 5.1 3.9 7.8 0.1 2.7 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_2 PF12756.7 ETO22235.1 - 1.3 9.4 0.0 1.3 9.4 0.0 4.7 6 0 0 6 6 6 0 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ETO22235.1 - 2.3 8.9 16.0 1.1 10.0 0.3 4.0 4 0 0 4 4 4 0 Zinc finger C2H2-type, 3 repeats SNF2_N PF00176.23 ETO22236.1 - 1.9e-25 89.4 0.1 1.9e-25 89.4 0.1 2.1 2 1 0 2 2 2 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO22236.1 - 0.01 15.8 0.1 0.1 12.6 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit eIF3_N PF09440.10 ETO22236.1 - 0.36 11.3 4.2 0.94 9.9 4.2 1.7 1 0 0 1 1 1 0 eIF3 subunit 6 N terminal domain CorA PF01544.18 ETO22236.1 - 0.8 9.0 6.8 1.4 8.2 6.8 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein PH PF00169.29 ETO22237.1 - 1.4e-11 44.8 0.6 5.9e-11 42.8 0.1 2.4 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO22237.1 - 6.9e-10 39.3 0.1 2.3e-09 37.6 0.1 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ETO22237.1 - 0.0031 17.7 0.0 0.29 11.5 0.0 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain YccV-like PF08755.11 ETO22237.1 - 0.052 14.1 0.0 0.12 12.9 0.0 1.6 1 0 0 1 1 1 0 Hemimethylated DNA-binding protein YccV like Ku_N PF03731.15 ETO22237.1 - 0.064 13.0 3.9 2.7 7.7 0.0 3.3 3 1 1 4 4 4 0 Ku70/Ku80 N-terminal alpha/beta domain PH_2 PF08458.10 ETO22238.1 - 0.00024 21.4 0.3 0.0036 17.6 0.0 2.2 2 0 0 2 2 2 1 Plant pleckstrin homology-like region CPP1-like PF11833.8 ETO22240.1 - 0.029 14.0 1.4 0.037 13.7 1.4 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Amidinotransf PF02274.17 ETO22240.1 - 0.064 12.3 1.9 0.068 12.2 1.9 1.0 1 0 0 1 1 1 0 Amidinotransferase Connexin PF00029.19 ETO22240.1 - 0.1 12.3 4.9 0.11 12.3 4.9 1.1 1 0 0 1 1 1 0 Connexin OATP PF03137.20 ETO22240.1 - 2.1 6.5 3.9 2.6 6.2 3.9 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3464 PF11947.8 ETO22240.1 - 8.4 6.1 8.8 10 5.8 8.8 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF1961 PF09224.11 ETO22241.1 - 2.9e-05 23.5 36.5 9.1 5.6 0.1 9.8 1 1 10 11 11 11 11 Domain of unknown function (DUF1961) APOBEC3 PF18771.1 ETO22241.1 - 3.2e-05 24.1 1.7 97 3.1 0.0 6.8 3 2 3 7 7 7 0 APOBEC3 PutA_N PF18083.1 ETO22242.1 - 0.019 15.0 0.9 0.023 14.7 0.9 1.1 1 0 0 1 1 1 0 Proline utilization A N-terminal domain DUF4470 PF14737.6 ETO22242.1 - 0.023 14.9 0.1 0.024 14.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) HrpA_pilin PF09589.10 ETO22243.1 - 5 7.9 13.8 13 6.6 0.7 2.6 1 1 0 2 2 2 0 HrpA pilus formation protein fn3 PF00041.21 ETO22244.1 - 0.00021 21.5 0.0 0.00052 20.3 0.0 1.6 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ETO22244.1 - 0.0013 19.2 0.0 0.0024 18.4 0.0 1.4 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain NINJA_B PF16136.5 ETO22245.1 - 0.16 12.3 0.4 0.19 12.1 0.4 1.1 1 0 0 1 1 1 0 Putative nuclear localisation signal FAM76 PF16046.5 ETO22246.1 - 3.1 7.1 7.7 4.1 6.7 7.7 1.2 1 0 0 1 1 1 0 FAM76 protein Acyl-CoA_dh_N PF02771.16 ETO22248.1 - 1.8e-13 51.2 0.0 2.6e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETO22248.1 - 9.2e-10 38.6 0.0 1.5e-09 38.0 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_1 PF00441.24 ETO22249.1 - 2.8e-34 118.5 1.8 4.4e-34 117.8 1.8 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO22249.1 - 1.5e-16 60.9 0.2 2e-16 60.5 0.2 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain FbpA PF05833.11 ETO22251.1 - 1.6e-27 96.4 0.1 1.9e-27 96.2 0.1 1.0 1 0 0 1 1 1 1 Fibronectin-binding protein A N-terminus (FbpA) Glyco_hydro_98M PF08306.11 ETO22251.1 - 0.061 12.6 0.0 0.092 12.0 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 98 DUF1770 PF08589.10 ETO22252.1 - 0.18 12.8 9.7 0.57 11.2 3.3 3.0 2 0 0 2 2 2 0 Fungal protein of unknown function (DUF1770) DUF3141 PF11339.8 ETO22252.1 - 0.19 10.1 1.8 0.29 9.5 1.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) IES5 PF17335.2 ETO22252.1 - 1.1 9.5 9.2 0.13 12.6 1.8 2.9 3 0 0 3 3 3 0 Ino80 complex subunit 5 Beach PF02138.18 ETO22253.1 - 1.2e-39 136.4 0.0 1.2e-39 136.4 0.0 1.7 2 1 0 2 2 2 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO22253.1 - 1.1e-11 44.7 0.4 3.1e-11 43.2 0.4 1.8 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Dabb PF07876.12 ETO22254.1 - 5.3e-13 49.4 0.0 6.9e-13 49.0 0.0 1.1 1 0 0 1 1 1 1 Stress responsive A/B Barrel Domain LigT_PEase PF02834.16 ETO22254.1 - 0.14 12.3 0.1 9.2 6.5 0.0 2.3 2 1 0 2 2 2 0 LigT like Phosphoesterase Chromo PF00385.24 ETO22255.1 - 4.3e-10 39.3 0.9 1.1e-09 38.1 0.9 1.7 1 0 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain SAM_2 PF07647.17 ETO22256.1 - 8.7e-05 22.6 0.6 0.00043 20.3 0.1 2.5 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO22256.1 - 0.042 14.3 1.0 0.17 12.3 0.1 2.4 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO22256.1 - 0.19 11.7 0.1 0.19 11.7 0.1 2.1 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain RPN2_C PF18004.1 ETO22256.1 - 0.72 9.8 18.8 0.018 14.9 10.9 2.0 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain zf-C3HC4 PF00097.25 ETO22257.1 - 1.6e-09 37.5 9.0 5.5e-09 35.7 9.0 2.0 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO22257.1 - 1.8e-09 37.6 12.3 2e-09 37.5 9.9 2.2 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ETO22257.1 - 5.4e-09 35.9 5.4 5.4e-09 35.9 5.4 2.3 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO22257.1 - 3.5e-07 30.0 5.4 9.7e-07 28.6 5.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO22257.1 - 9.9e-07 28.6 7.4 9.9e-07 28.6 7.4 2.3 2 0 0 2 2 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETO22257.1 - 1.1e-06 28.8 8.4 3.6e-06 27.2 8.4 1.9 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO22257.1 - 1.4e-06 28.0 9.4 5.3e-06 26.2 9.4 2.1 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 ETO22257.1 - 0.0012 18.9 4.6 0.0029 17.7 4.6 1.7 1 0 0 1 1 1 1 zinc RING finger of MSL2 U-box PF04564.15 ETO22257.1 - 0.0026 17.9 0.1 0.017 15.3 0.0 2.3 2 0 0 2 2 2 1 U-box domain zf-RING_4 PF14570.6 ETO22257.1 - 0.0027 17.5 7.0 0.41 10.5 8.7 2.6 1 1 1 2 2 2 1 RING/Ubox like zinc-binding domain zinc_ribbon_9 PF14369.6 ETO22257.1 - 0.0064 16.7 1.3 0.26 11.6 0.6 2.6 2 0 0 2 2 2 1 zinc-ribbon zf-ANAPC11 PF12861.7 ETO22257.1 - 0.046 13.8 3.0 0.2 11.8 3.0 2.1 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO22257.1 - 0.051 13.4 12.1 1.2 9.0 12.5 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 ETO22257.1 - 0.19 11.6 2.8 0.41 10.5 2.8 1.5 1 0 0 1 1 1 0 zf-RING of BARD1-type protein zf-Nse PF11789.8 ETO22257.1 - 0.24 11.2 4.6 0.59 10.0 3.8 2.1 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-RING_11 PF17123.5 ETO22257.1 - 0.3 10.9 3.9 1.1 9.1 3.9 2.0 1 0 0 1 1 1 0 RING-like zinc finger Rad50_zn_hook PF04423.14 ETO22257.1 - 0.34 10.8 0.0 0.34 10.8 0.0 3.4 4 0 0 4 4 3 0 Rad50 zinc hook motif DUF1451 PF07295.11 ETO22257.1 - 0.73 9.9 6.9 0.4 10.7 4.0 2.1 2 0 0 2 2 2 0 Zinc-ribbon containing domain TRAF6_Z2 PF18048.1 ETO22257.1 - 1.8 8.7 8.3 0.62 10.2 3.0 2.6 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 zf-rbx1 PF12678.7 ETO22257.1 - 2 8.7 9.0 84 3.6 9.5 3.0 1 1 1 2 2 2 0 RING-H2 zinc finger domain zf-MIZ PF02891.20 ETO22257.1 - 3.5 7.5 9.5 14 5.6 9.5 2.0 1 1 0 1 1 1 0 MIZ/SP-RING zinc finger zf-RING_2 PF13639.6 ETO22258.1 - 9.3e-12 45.1 4.2 1.4e-11 44.5 4.2 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO22258.1 - 4e-08 32.9 1.3 4e-08 32.9 1.3 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO22258.1 - 5.1e-08 32.6 3.8 7.8e-08 32.0 3.8 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO22258.1 - 8.9e-08 32.0 2.9 1.4e-07 31.4 2.9 1.3 1 0 0 1 1 1 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETO22258.1 - 2.3e-06 27.8 6.4 9.2e-06 25.9 6.4 2.0 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETO22258.1 - 2e-05 24.4 1.1 3.7e-05 23.5 1.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO22258.1 - 0.00053 19.8 3.1 0.00092 19.0 3.1 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO22258.1 - 0.0043 17.0 1.5 0.0068 16.4 0.3 1.9 1 1 1 2 2 2 1 RING-type zinc-finger DUF4553 PF15090.6 ETO22258.1 - 0.034 13.2 3.8 0.041 12.9 3.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4553) Prok-RING_4 PF14447.6 ETO22258.1 - 0.043 13.7 2.9 0.07 13.0 2.9 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-Nse PF11789.8 ETO22258.1 - 0.055 13.3 2.7 0.095 12.5 2.7 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit XPA_N PF01286.18 ETO22258.1 - 0.13 12.3 1.6 0.29 11.2 0.0 2.1 2 0 0 2 2 2 0 XPA protein N-terminal Zn_ribbon_17 PF17120.5 ETO22258.1 - 0.15 11.7 1.5 0.25 11.0 1.5 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-ANAPC11 PF12861.7 ETO22258.1 - 0.19 11.8 2.5 0.4 10.8 2.5 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc_ribbon_16 PF17034.5 ETO22258.1 - 0.23 11.7 3.2 0.66 10.2 3.2 1.9 1 1 0 1 1 1 0 Zinc-ribbon like family PBP1_TM PF14812.6 ETO22258.1 - 1.5 9.3 4.9 3.2 8.2 4.9 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Presenilin PF01080.17 ETO22258.1 - 3.5 6.3 4.5 3.6 6.2 4.5 1.1 1 0 0 1 1 1 0 Presenilin SAM_2 PF07647.17 ETO22259.1 - 0.045 13.9 0.0 0.12 12.5 0.0 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DNA_RNApol_7kD PF03604.13 ETO22259.1 - 0.055 13.2 4.6 2.2 8.0 0.6 2.5 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit SAM_1 PF00536.30 ETO22259.1 - 0.13 12.7 0.0 0.4 11.2 0.0 1.9 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) MMTV_SAg PF01054.17 ETO22259.1 - 0.14 11.6 1.3 0.24 10.9 1.3 1.3 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen YabA PF06156.13 ETO22259.1 - 1.9 9.1 11.2 2 9.1 6.0 2.5 2 1 0 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 ETO22259.1 - 7.1 5.9 6.5 11 5.3 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GPHR_N PF12537.8 ETO22260.1 - 1.1e-18 67.0 0.0 2.3e-17 62.8 0.0 2.6 2 0 0 2 2 2 1 The Golgi pH Regulator (GPHR) Family N-terminal ABA_GPCR PF12430.8 ETO22260.1 - 2.1e-15 56.9 1.4 2.1e-15 56.9 1.4 2.0 2 0 0 2 2 2 1 Abscisic acid G-protein coupled receptor TRIQK PF15168.6 ETO22260.1 - 0.52 10.2 2.1 1.8 8.5 0.0 2.6 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family CENP-B_dimeris PF09026.10 ETO22261.1 - 0.007 16.7 2.0 0.012 15.9 2.0 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO22261.1 - 0.084 12.5 0.7 0.17 11.6 0.7 1.4 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO22261.1 - 3.1 7.0 9.5 5.1 6.3 9.5 1.3 1 0 0 1 1 1 0 NOA36 protein Utp14 PF04615.13 ETO22261.1 - 6.4 5.2 11.4 8 4.9 11.4 1.1 1 0 0 1 1 1 0 Utp14 protein Utp13 PF08625.11 ETO22262.1 - 0.0066 16.4 0.1 0.0077 16.1 0.1 1.3 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain USP8_dimer PF08969.11 ETO22263.1 - 2.4e-08 34.2 2.3 4.1e-08 33.4 2.3 1.3 1 0 0 1 1 1 1 USP8 dimerisation domain DUF4574 PF15141.6 ETO22263.1 - 0.047 13.6 1.4 0.093 12.7 1.4 1.5 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 CobT PF06213.12 ETO22263.1 - 0.07 12.5 8.2 0.084 12.3 8.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4175 PF13779.6 ETO22263.1 - 0.077 10.9 7.7 0.092 10.6 7.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) CDC45 PF02724.14 ETO22263.1 - 0.32 9.3 7.5 0.31 9.3 7.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Voldacs PF03517.13 ETO22263.1 - 0.6 10.2 5.0 1.6 8.9 5.0 1.7 1 1 0 1 1 1 0 Regulator of volume decrease after cellular swelling Nop53 PF07767.11 ETO22263.1 - 1.8 7.9 21.5 2.2 7.6 21.5 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RPN2_C PF18004.1 ETO22263.1 - 1.9 8.4 13.0 2.6 8.0 13.0 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4746 PF15928.5 ETO22263.1 - 2.2 7.6 11.0 2.5 7.5 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) ZZ PF00569.17 ETO22264.1 - 1.2e-11 44.2 9.7 1.2e-11 44.2 9.7 3.6 2 1 0 2 2 2 1 Zinc finger, ZZ type PB1 PF00564.24 ETO22264.1 - 1.5e-07 31.2 0.0 3.3e-07 30.2 0.0 1.6 1 0 0 1 1 1 1 PB1 domain Borrelia_P83 PF05262.11 ETO22264.1 - 0.00075 18.1 22.2 0.00075 18.1 22.2 1.6 2 0 0 2 2 2 1 Borrelia P83/100 protein Dapper PF15268.6 ETO22264.1 - 0.92 8.3 27.3 0.21 10.4 22.1 2.0 2 0 0 2 2 2 0 Dapper VIT1 PF01988.19 ETO22264.1 - 2.5 7.9 5.5 6 6.7 5.5 1.6 1 0 0 1 1 1 0 VIT family Nop14 PF04147.12 ETO22264.1 - 4.3 5.4 43.4 0.047 11.9 35.7 1.5 2 0 0 2 2 2 0 Nop14-like family Atypical_Card PF18461.1 ETO22267.1 - 0.43 10.8 3.3 1.4 9.2 0.3 2.9 3 0 0 3 3 3 0 Atypical caspase recruitment domain YjbH PF06082.11 ETO22267.1 - 2.6 6.8 7.3 0.77 8.5 0.1 2.1 2 0 0 2 2 2 0 Exopolysaccharide biosynthesis protein YbjH PHD PF00628.29 ETO22269.1 - 0.00011 22.0 3.1 0.00011 22.0 3.1 2.3 2 0 0 2 2 2 1 PHD-finger ELM2 PF01448.24 ETO22270.1 - 0.15 12.9 0.1 0.72 10.7 0.0 2.1 2 1 0 2 2 2 0 ELM2 domain RNase_PH_C PF03725.15 ETO22271.1 - 0.11 12.5 0.7 18 5.5 0.0 2.4 2 0 0 2 2 2 0 3' exoribonuclease family, domain 2 Asp PF00026.23 ETO22272.1 - 7.9e-39 133.9 14.2 2.3e-37 129.1 14.2 2.0 1 1 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO22272.1 - 3.9e-09 37.0 6.6 7e-08 32.9 1.7 3.2 2 2 1 3 3 3 1 Xylanase inhibitor N-terminal TAXi_C PF14541.6 ETO22272.1 - 0.00064 19.5 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 Xylanase inhibitor C-terminal CarbopepD_reg_2 PF13715.6 ETO22273.1 - 0.00014 21.8 3.0 0.0007 19.5 0.1 2.3 2 0 0 2 2 2 1 CarboxypepD_reg-like domain CarboxypepD_reg PF13620.6 ETO22273.1 - 0.052 13.8 0.1 0.16 12.3 0.1 1.9 1 1 1 2 2 2 0 Carboxypeptidase regulatory-like domain TPR_12 PF13424.6 ETO22274.1 - 4.2e-27 94.2 0.0 5.3e-16 58.7 0.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22274.1 - 3.5e-22 77.6 0.0 5.5e-07 29.2 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22274.1 - 2.3e-18 65.1 9.8 5.1e-09 35.6 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22274.1 - 4.7e-18 63.8 5.0 7.6e-07 28.8 0.1 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22274.1 - 7.8e-16 56.9 0.6 6.5e-07 28.9 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22274.1 - 2.4e-14 52.3 9.8 8.9e-06 25.5 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22274.1 - 2.8e-08 33.3 10.2 8e-05 22.2 0.1 3.8 4 0 0 4 4 4 2 TPR repeat DUF2225 PF09986.9 ETO22274.1 - 0.00079 19.2 0.6 0.0066 16.2 0.1 2.5 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO22274.1 - 0.0011 19.0 1.2 0.94 9.6 0.0 4.2 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO22274.1 - 0.0012 19.0 0.1 6 7.3 0.0 4.0 4 0 0 4 4 4 1 PPR repeat TPR_6 PF13174.6 ETO22274.1 - 0.0017 18.8 0.4 0.63 10.8 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 ETO22274.1 - 0.0025 17.3 0.2 0.32 10.4 0.0 2.4 1 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO22274.1 - 0.0033 17.7 5.7 0.015 15.7 0.5 4.1 4 1 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22274.1 - 0.0061 17.3 0.0 2.1 9.4 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO22274.1 - 0.017 14.5 0.0 0.032 13.6 0.0 1.4 1 0 0 1 1 1 0 MalT-like TPR region CLTH PF10607.9 ETO22274.1 - 0.031 14.2 4.4 2 8.3 2.5 3.2 2 1 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain SPO22 PF08631.10 ETO22274.1 - 0.034 13.6 4.2 1.6 8.1 0.0 3.3 3 1 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 ETO22274.1 - 0.16 12.5 0.0 0.51 10.9 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat WD40 PF00400.32 ETO22275.1 - 5.3e-24 84.0 14.6 5.3e-08 33.4 1.0 3.4 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO22275.1 - 4e-11 42.3 0.6 1.9e-05 23.5 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO22275.1 - 5.2e-08 33.1 0.1 0.046 14.0 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO22275.1 - 1.8e-05 24.2 1.3 0.00011 21.7 1.1 2.0 1 1 1 2 2 2 2 WD40-like domain CENP-F_leu_zip PF10473.9 ETO22276.1 - 2.8e-06 27.4 24.5 2.8e-06 27.4 24.5 1.8 2 1 0 2 2 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4795 PF16043.5 ETO22276.1 - 0.00021 21.0 18.4 0.00035 20.2 18.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) ABC2_membrane_3 PF12698.7 ETO22276.1 - 0.0026 16.9 3.5 0.0029 16.8 3.5 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein TPR_MLP1_2 PF07926.12 ETO22276.1 - 0.0063 16.6 16.2 0.0063 16.6 16.2 2.6 2 1 1 3 3 2 1 TPR/MLP1/MLP2-like protein DUF4164 PF13747.6 ETO22276.1 - 0.0076 16.5 12.8 0.011 16.0 6.3 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4164) DUF724 PF05266.14 ETO22276.1 - 0.012 15.5 14.2 0.012 15.5 14.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 ETO22276.1 - 0.014 15.5 16.9 0.037 14.1 7.4 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Spc24 PF08286.11 ETO22276.1 - 0.022 15.0 5.7 0.022 15.0 5.7 3.7 2 1 2 4 4 4 0 Spc24 subunit of Ndc80 PI3K_P85_iSH2 PF16454.5 ETO22276.1 - 0.022 14.3 20.8 0.021 14.4 7.0 2.5 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Tektin PF03148.14 ETO22276.1 - 0.042 12.6 22.3 0.099 11.4 22.2 1.8 1 1 0 1 1 1 0 Tektin family Spc7 PF08317.11 ETO22276.1 - 0.06 12.2 28.5 0.057 12.3 17.5 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 ETO22276.1 - 0.14 11.2 21.8 0.22 10.6 21.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 ETO22276.1 - 0.25 11.6 27.5 0.15 12.3 9.3 2.6 2 1 1 3 3 2 0 Seryl-tRNA synthetase N-terminal domain ADIP PF11559.8 ETO22276.1 - 0.29 11.2 31.7 3 7.9 12.3 2.5 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding FUSC PF04632.12 ETO22276.1 - 0.35 9.4 1.7 0.43 9.1 1.7 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family DUF5082 PF16888.5 ETO22276.1 - 0.53 10.6 33.7 0.27 11.5 2.7 3.9 2 1 3 5 5 5 0 Domain of unknown function (DUF5082) LMBR1 PF04791.16 ETO22276.1 - 0.56 9.1 10.3 0.84 8.5 10.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_13 PF13166.6 ETO22276.1 - 0.59 8.7 24.6 1.4 7.4 24.4 1.7 1 1 0 1 1 1 0 AAA domain ATG16 PF08614.11 ETO22276.1 - 0.88 9.8 32.6 0.06 13.6 14.5 2.3 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) DUF4140 PF13600.6 ETO22276.1 - 1.2 9.7 18.9 56 4.3 4.4 3.5 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Jnk-SapK_ap_N PF09744.9 ETO22276.1 - 1.3 9.2 32.9 3.1 8.0 28.3 2.6 2 1 0 2 2 2 0 JNK_SAPK-associated protein-1 HAUS-augmin3 PF14932.6 ETO22276.1 - 1.3 8.5 25.6 2.6 7.6 23.9 2.0 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 FlaC_arch PF05377.11 ETO22276.1 - 1.8 9.0 12.0 2.9 8.3 1.9 3.6 1 1 1 3 3 3 0 Flagella accessory protein C (FlaC) Noelin-1 PF12308.8 ETO22276.1 - 2.1 8.4 15.2 0.24 11.4 4.0 2.4 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF3450 PF11932.8 ETO22276.1 - 2.1 7.6 25.3 0.67 9.2 17.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Caskin-tail PF16632.5 ETO22276.1 - 2.1 8.8 11.7 0.11 12.9 1.4 2.9 2 1 0 2 2 2 0 C-terminal region of Caskin THOC7 PF05615.13 ETO22276.1 - 2.4 8.4 19.5 6.9 7.0 19.0 2.1 1 1 0 1 1 1 0 Tho complex subunit 7 Macoilin PF09726.9 ETO22276.1 - 2.5 6.6 25.1 3.2 6.2 25.1 1.1 1 0 0 1 1 1 0 Macoilin family HOOK PF05622.12 ETO22276.1 - 3.3 5.7 31.7 0.83 7.7 28.8 1.4 1 1 1 2 2 2 0 HOOK protein PspA_IM30 PF04012.12 ETO22276.1 - 3.4 7.2 25.1 5.9 6.4 10.7 2.5 1 1 0 2 2 2 0 PspA/IM30 family DUF4661 PF15576.6 ETO22276.1 - 3.6 7.4 9.7 0.29 11.0 3.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4661) bZIP_1 PF00170.21 ETO22276.1 - 4.3 7.5 19.3 2 8.6 0.6 3.9 1 1 3 4 4 3 0 bZIP transcription factor Allexi_40kDa PF05549.11 ETO22276.1 - 4.9 6.6 15.6 1.1 8.8 9.3 2.0 1 1 1 2 2 2 0 Allexivirus 40kDa protein APG6_N PF17675.1 ETO22276.1 - 5.4 7.6 35.1 7.9 7.0 29.8 2.8 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF2175 PF09943.9 ETO22276.1 - 5.5 7.3 11.9 1.9 8.9 4.2 3.2 1 1 2 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2175) SLIDE PF09111.10 ETO22276.1 - 5.6 7.0 11.8 4.5 7.3 1.9 2.4 2 0 0 2 2 2 0 SLIDE ATG16 PF08614.11 ETO22277.1 - 1.5e-07 31.8 28.0 0.006 16.8 32.5 3.0 2 1 0 2 2 2 1 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 ETO22277.1 - 2.1e-07 31.1 43.5 1.9e-06 27.9 23.8 3.0 2 1 1 3 3 3 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Filament PF00038.21 ETO22277.1 - 4.2e-05 23.3 30.7 0.061 12.9 12.1 3.1 2 1 1 3 3 3 3 Intermediate filament protein DUF4407 PF14362.6 ETO22277.1 - 5.9e-05 22.6 16.3 5.9e-05 22.6 16.3 1.4 2 0 0 2 2 1 1 Domain of unknown function (DUF4407) BRE1 PF08647.11 ETO22277.1 - 0.00012 22.0 35.2 0.00095 19.2 16.4 3.8 2 1 2 4 4 4 2 BRE1 E3 ubiquitin ligase ERM PF00769.19 ETO22277.1 - 0.00013 21.9 26.7 0.00029 20.7 26.7 1.7 1 1 0 1 1 1 1 Ezrin/radixin/moesin family Spc7 PF08317.11 ETO22277.1 - 0.00014 20.9 15.1 0.00014 20.9 15.1 2.4 2 1 1 3 3 2 2 Spc7 kinetochore protein YabA PF06156.13 ETO22277.1 - 0.0008 20.0 28.7 0.73 10.5 5.3 3.9 2 1 2 4 4 4 2 Initiation control protein YabA Atg14 PF10186.9 ETO22277.1 - 0.0012 18.0 20.1 0.0012 18.0 20.1 2.9 2 1 1 3 3 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 LMBR1 PF04791.16 ETO22277.1 - 0.0015 17.5 10.5 0.002 17.1 10.5 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein Tropomyosin_1 PF12718.7 ETO22277.1 - 0.0017 18.5 37.0 0.0047 17.1 12.4 3.8 2 1 2 4 4 4 2 Tropomyosin like Lebercilin PF15619.6 ETO22277.1 - 0.0018 18.0 5.6 0.0018 18.0 5.6 3.1 2 1 1 3 3 3 1 Ciliary protein causing Leber congenital amaurosis disease ZapB PF06005.12 ETO22277.1 - 0.0035 17.8 41.3 0.38 11.2 6.8 4.2 2 1 2 4 4 4 2 Cell division protein ZapB DUF3450 PF11932.8 ETO22277.1 - 0.0035 16.7 30.8 0.01 15.1 17.9 2.3 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) EzrA PF06160.12 ETO22277.1 - 0.0046 15.2 23.1 0.0088 14.3 23.1 1.4 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA APG6_N PF17675.1 ETO22277.1 - 0.0047 17.5 38.8 0.023 15.2 14.6 3.0 2 1 1 3 3 3 2 Apg6 coiled-coil region LPP PF04728.13 ETO22277.1 - 0.0057 17.0 25.4 0.41 11.1 3.9 4.6 2 1 4 6 6 5 2 Lipoprotein leucine-zipper TPR_MLP1_2 PF07926.12 ETO22277.1 - 0.007 16.4 38.9 0.13 12.3 18.9 3.0 2 1 0 2 2 2 1 TPR/MLP1/MLP2-like protein MT PF12777.7 ETO22277.1 - 0.0082 15.2 2.0 0.0082 15.2 2.0 2.2 1 1 0 2 2 2 1 Microtubule-binding stalk of dynein motor KASH_CCD PF14662.6 ETO22277.1 - 0.011 15.6 38.2 0.04 13.7 19.9 3.3 2 1 1 3 3 3 0 Coiled-coil region of CCDC155 or KASH FUSC PF04632.12 ETO22277.1 - 0.011 14.3 1.3 0.012 14.2 1.3 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family Cnn_1N PF07989.11 ETO22277.1 - 0.013 15.6 29.4 0.45 10.7 10.3 4.2 2 1 2 4 4 4 0 Centrosomin N-terminal motif 1 TSC22 PF01166.18 ETO22277.1 - 0.024 14.9 21.6 0.15 12.4 2.6 4.6 2 1 2 4 4 4 0 TSC-22/dip/bun family FlaC_arch PF05377.11 ETO22277.1 - 0.024 15.0 22.8 0.29 11.5 1.0 4.6 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Leu_zip PF15294.6 ETO22277.1 - 0.029 13.9 28.9 10 5.5 1.4 2.8 2 1 0 2 2 2 0 Leucine zipper GAS PF13851.6 ETO22277.1 - 0.033 13.5 37.2 0.17 11.3 14.4 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding PKcGMP_CC PF16808.5 ETO22277.1 - 0.046 13.6 3.0 9.6 6.1 0.0 3.7 5 0 0 5 5 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase HOOK PF05622.12 ETO22277.1 - 0.046 11.9 32.1 0.034 12.3 10.9 2.6 2 1 1 3 3 3 0 HOOK protein Myosin_tail_1 PF01576.19 ETO22277.1 - 0.052 11.4 26.6 0.082 10.7 24.1 1.9 2 0 0 2 2 2 0 Myosin tail DUF1664 PF07889.12 ETO22277.1 - 0.061 13.4 19.2 0.42 10.6 6.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc29 PF17082.5 ETO22277.1 - 0.066 13.1 19.8 0.15 11.9 7.8 2.4 1 1 1 2 2 2 0 Spindle Pole Component 29 IFT57 PF10498.9 ETO22277.1 - 0.088 11.8 37.0 0.011 14.7 19.5 2.5 2 1 1 3 3 2 0 Intra-flagellar transport protein 57 DUF4763 PF15960.5 ETO22277.1 - 0.089 12.1 23.9 0.15 11.3 23.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) bZIP_1 PF00170.21 ETO22277.1 - 0.091 12.9 32.5 0.19 11.9 4.5 5.3 2 1 2 5 5 5 0 bZIP transcription factor DivIC PF04977.15 ETO22277.1 - 0.093 12.5 36.3 0.11 12.3 6.8 4.8 2 1 2 4 4 4 0 Septum formation initiator Cast PF10174.9 ETO22277.1 - 0.1 10.8 30.2 0.0098 14.2 24.6 1.8 2 0 0 2 2 2 0 RIM-binding protein of the cytomatrix active zone RPW8 PF05659.11 ETO22277.1 - 0.1 12.3 0.1 0.1 12.3 0.1 3.5 2 1 2 4 4 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 AAA_13 PF13166.6 ETO22277.1 - 0.11 11.2 25.9 0.25 10.0 7.4 2.0 1 1 1 2 2 2 0 AAA domain CALCOCO1 PF07888.11 ETO22277.1 - 0.11 11.4 31.3 0.0054 15.7 25.4 1.7 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Prominin PF05478.11 ETO22277.1 - 0.16 9.9 18.7 0.3 9.0 18.7 1.5 1 0 0 1 1 1 0 Prominin Fez1 PF06818.15 ETO22277.1 - 0.17 12.4 28.7 0.31 11.5 13.7 2.6 1 1 1 2 2 2 0 Fez1 FliJ PF02050.16 ETO22277.1 - 0.18 12.0 28.7 0.18 12.1 9.5 3.1 1 1 1 2 2 2 0 Flagellar FliJ protein ADIP PF11559.8 ETO22277.1 - 0.22 11.6 42.5 0.18 11.9 11.7 3.6 2 1 2 4 4 4 0 Afadin- and alpha -actinin-Binding GWT1 PF06423.12 ETO22277.1 - 0.27 11.4 4.5 0.8 9.8 4.5 1.8 1 1 0 1 1 1 0 GWT1 Prefoldin_2 PF01920.20 ETO22277.1 - 0.27 11.2 37.4 0.42 10.6 7.8 4.2 3 1 2 5 5 5 0 Prefoldin subunit DUF4686 PF15742.5 ETO22277.1 - 0.28 10.3 33.0 0.48 9.5 28.4 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4686) TMF_TATA_bd PF12325.8 ETO22277.1 - 0.32 11.2 29.9 0.056 13.7 3.5 3.4 2 1 2 4 4 3 0 TATA element modulatory factor 1 TATA binding DIE2_ALG10 PF04922.12 ETO22277.1 - 0.38 10.0 4.1 0.15 11.3 1.7 1.5 1 1 1 2 2 2 0 DIE2/ALG10 family Cob_adeno_trans PF01923.18 ETO22277.1 - 0.39 10.9 8.9 0.19 11.8 5.0 2.2 1 1 1 2 2 2 0 Cobalamin adenosyltransferase Tektin PF03148.14 ETO22277.1 - 0.4 9.4 27.0 15 4.2 11.6 2.7 1 1 1 2 2 2 0 Tektin family RasGAP_C PF03836.15 ETO22277.1 - 0.41 10.8 26.1 0.17 12.1 4.2 3.1 1 1 1 2 2 2 0 RasGAP C-terminus DHR10 PF18595.1 ETO22277.1 - 0.65 10.1 39.3 0.42 10.7 10.2 3.3 2 1 1 3 3 2 0 Designed helical repeat protein 10 domain DUF5129 PF17173.4 ETO22277.1 - 0.65 9.1 8.3 0.78 8.8 8.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) Uso1_p115_C PF04871.13 ETO22277.1 - 0.75 10.2 36.9 0.68 10.3 19.8 3.4 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region SpecificRecomb PF10136.9 ETO22277.1 - 0.88 7.8 10.0 1.3 7.2 10.0 1.2 1 0 0 1 1 1 0 Site-specific recombinase AIP3 PF03915.13 ETO22277.1 - 0.92 8.5 21.3 1.4 8.0 21.3 1.3 1 0 0 1 1 1 0 Actin interacting protein 3 WEMBL PF05701.11 ETO22277.1 - 0.97 8.1 23.1 7.1 5.2 23.1 2.0 1 1 0 1 1 1 0 Weak chloroplast movement under blue light Seryl_tRNA_N PF02403.22 ETO22277.1 - 1 9.6 31.3 2.4 8.5 15.5 3.7 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF724 PF05266.14 ETO22277.1 - 1 9.1 32.0 0.19 11.5 15.7 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF724) PspA_IM30 PF04012.12 ETO22277.1 - 1.1 8.8 30.8 0.15 11.6 13.8 2.5 2 1 1 3 3 2 0 PspA/IM30 family bZIP_2 PF07716.15 ETO22277.1 - 1.1 9.4 27.4 0.42 10.7 1.9 5.3 3 2 3 6 6 5 0 Basic region leucine zipper TMF_DNA_bd PF12329.8 ETO22277.1 - 1.2 9.2 46.6 0.62 10.1 6.7 4.3 2 1 1 4 4 4 0 TATA element modulatory factor 1 DNA binding DUF812 PF05667.11 ETO22277.1 - 1.3 7.9 34.4 0.25 10.2 4.2 2.4 2 1 1 3 3 2 0 Protein of unknown function (DUF812) CCDC144C PF14915.6 ETO22277.1 - 1.3 8.0 33.6 0.039 13.1 27.1 1.6 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region MscS_porin PF12795.7 ETO22277.1 - 1.5 8.3 38.6 4.6 6.7 38.6 1.8 1 1 0 1 1 1 0 Mechanosensitive ion channel porin domain Rx_N PF18052.1 ETO22277.1 - 1.6 9.1 13.2 0.17 12.1 1.0 3.4 2 1 1 3 3 3 0 Rx N-terminal domain SLATT_5 PF18160.1 ETO22277.1 - 1.6 8.0 10.9 2.5 7.4 8.3 2.3 1 1 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 Golgin_A5 PF09787.9 ETO22277.1 - 1.6 8.1 32.8 0.019 14.4 18.4 2.3 2 1 1 3 3 2 0 Golgin subfamily A member 5 DUF4472 PF14739.6 ETO22277.1 - 1.7 9.4 29.4 1.5 9.6 10.7 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4472) DUF5082 PF16888.5 ETO22277.1 - 2.2 8.6 31.2 0.1 12.9 19.1 2.7 2 1 1 3 3 2 0 Domain of unknown function (DUF5082) TEX13 PF15186.6 ETO22277.1 - 2.3 7.9 17.5 2.9 7.5 9.0 2.5 1 1 1 2 2 2 0 Testis-expressed sequence 13 protein family HAP1_N PF04849.13 ETO22277.1 - 2.3 7.3 34.0 0.66 9.1 24.5 3.0 2 1 1 3 3 3 0 HAP1 N-terminal conserved region Syntaxin-6_N PF09177.11 ETO22277.1 - 2.4 8.8 25.2 3.1 8.4 4.1 3.4 2 1 2 4 4 3 0 Syntaxin 6, N-terminal TolA_bind_tri PF16331.5 ETO22277.1 - 2.7 8.2 30.3 0.33 11.0 5.4 3.8 1 1 2 3 3 3 0 TolA binding protein trimerisation DUF3584 PF12128.8 ETO22277.1 - 2.7 5.4 28.5 6.5 4.1 28.5 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) SHE3 PF17078.5 ETO22277.1 - 3 7.5 33.7 0.11 12.1 19.4 2.9 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 HAUS-augmin3 PF14932.6 ETO22277.1 - 3.3 7.2 30.4 1.2 8.6 18.5 2.3 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 FPP PF05911.11 ETO22277.1 - 3.3 5.8 29.2 19 3.2 29.2 1.9 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil TMPIT PF07851.13 ETO22277.1 - 3.4 6.8 27.2 26 4.0 26.2 2.5 1 1 1 2 2 2 0 TMPIT-like protein Occludin_ELL PF07303.13 ETO22277.1 - 3.5 8.4 20.2 2.6 8.8 2.4 3.1 1 1 1 2 2 2 0 Occludin homology domain Sec20 PF03908.13 ETO22277.1 - 4.2 7.4 18.5 1.7 8.6 9.7 3.5 2 1 1 3 3 2 0 Sec20 Nup54 PF13874.6 ETO22277.1 - 4.8 7.3 25.9 6.8 6.8 16.1 2.7 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 Sec34 PF04136.15 ETO22277.1 - 4.9 7.0 23.2 13 5.7 7.8 2.3 1 1 1 2 2 2 0 Sec34-like family DUF1515 PF07439.11 ETO22277.1 - 5.5 7.1 9.1 11 6.1 1.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) THOC7 PF05615.13 ETO22277.1 - 5.6 7.3 30.2 1.6 9.0 1.6 3.5 2 1 2 4 4 3 0 Tho complex subunit 7 COG5 PF10392.9 ETO22277.1 - 5.7 7.1 20.1 1.5 9.0 13.3 2.3 1 1 1 2 2 2 0 Golgi transport complex subunit 5 UPF0242 PF06785.11 ETO22277.1 - 5.8 7.0 38.6 2.1 8.4 19.5 3.1 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus CP12 PF02672.15 ETO22277.1 - 6.3 7.6 13.7 4.5 8.1 3.9 3.0 1 1 2 3 3 3 0 CP12 domain Jnk-SapK_ap_N PF09744.9 ETO22277.1 - 6.6 6.9 35.9 5 7.3 12.9 3.0 2 1 1 3 3 3 0 JNK_SAPK-associated protein-1 YscO-like PF16789.5 ETO22277.1 - 7.4 6.6 28.0 0.12 12.4 19.6 2.0 2 0 0 2 2 2 0 YscO-like protein Ribosomal_S20p PF01649.18 ETO22277.1 - 7.4 7.3 12.9 1.4 9.6 8.1 2.2 1 1 1 2 2 1 0 Ribosomal protein S20 DUF948 PF06103.11 ETO22277.1 - 7.7 6.9 15.4 2.8 8.3 3.9 3.0 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF1043 PF06295.12 ETO22277.1 - 8.6 6.4 27.8 0.13 12.3 14.3 2.7 2 1 1 3 3 2 0 Protein of unknown function (DUF1043) DUF4446 PF14584.6 ETO22277.1 - 8.8 6.3 24.5 0.78 9.7 2.7 3.8 2 1 2 4 4 4 0 Protein of unknown function (DUF4446) SlyX PF04102.12 ETO22277.1 - 8.9 7.0 30.1 0.19 12.3 3.2 3.6 2 1 2 4 4 3 0 SlyX EF_assoc_2 PF08356.12 ETO22278.1 - 0.12 12.4 0.9 0.42 10.6 0.1 2.0 2 0 0 2 2 2 0 EF hand associated AgrB PF04647.15 ETO22278.1 - 1.1 8.5 7.1 0.15 11.3 0.9 2.0 2 0 0 2 2 2 0 Accessory gene regulator B Exostosin PF03016.15 ETO22279.1 - 3.6e-13 49.4 0.1 1.3e-12 47.6 0.1 1.8 1 1 0 1 1 1 1 Exostosin family ETRAMP PF09716.10 ETO22280.1 - 0.059 13.4 1.1 0.11 12.6 1.1 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO22281.1 - 3.8e-12 46.5 1.6 6.5e-05 23.6 0.1 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO22281.1 - 0.0002 20.2 0.2 0.2 10.3 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO22282.1 - 2.7e-07 31.2 2.4 5.6e-07 30.2 2.4 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat EXS PF03124.14 ETO22283.1 - 3.3e-34 118.7 37.2 5.5e-31 108.1 17.6 3.1 1 1 2 3 3 3 2 EXS family SPX PF03105.19 ETO22283.1 - 4.2e-07 30.2 35.3 4.2e-07 30.2 35.3 2.8 2 1 0 2 2 2 1 SPX domain Rad21_Rec8_N PF04825.13 ETO22283.1 - 0.021 15.0 0.6 0.074 13.2 0.6 2.0 1 0 0 1 1 1 0 N terminus of Rad21 / Rec8 like protein TPR_14 PF13428.6 ETO22284.1 - 0.0009 19.9 2.5 0.3 12.0 0.0 3.4 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO22284.1 - 0.002 18.6 4.0 0.049 14.2 0.4 2.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22284.1 - 0.027 14.6 12.6 2.3 8.5 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22284.1 - 0.16 11.9 6.6 1.6 8.7 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22284.1 - 0.2 11.7 4.0 27 5.1 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO22284.1 - 0.34 11.2 8.5 16 5.9 1.4 3.8 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22284.1 - 0.54 11.0 2.4 7 7.4 0.8 2.3 1 1 1 2 2 2 0 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ETO22284.1 - 1.2 9.1 10.8 0.24 11.4 5.9 2.2 2 1 1 3 3 3 0 Putative TPR-like repeat Vps54 PF07928.12 ETO22285.1 - 5.8e-38 130.4 4.2 2.7e-37 128.2 4.2 2.2 1 0 0 1 1 1 1 Vps54-like protein IcmF_C PF06744.12 ETO22286.1 - 0.027 14.1 0.1 0.073 12.7 0.1 1.7 2 0 0 2 2 2 0 Type VI secretion protein IcmF C-terminal Secretin_N_2 PF07655.13 ETO22287.1 - 9.4 6.9 13.0 0.41 11.2 2.7 2.7 3 0 0 3 3 3 0 Secretin N-terminal domain ubiquitin PF00240.23 ETO22288.1 - 0.13 12.0 0.1 0.24 11.1 0.1 1.4 1 0 0 1 1 1 0 Ubiquitin family Macro PF01661.21 ETO22289.1 - 3.1e-12 46.6 0.2 1.1e-05 25.4 0.1 3.0 1 1 1 2 2 2 2 Macro domain MA3 PF02847.17 ETO22291.1 - 6.8e-10 38.9 2.4 5.8e-06 26.3 0.2 2.5 2 0 0 2 2 2 2 MA3 domain DUF1488 PF07369.11 ETO22291.1 - 0.024 14.6 0.0 0.07 13.1 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1488) Hpr_kinase_N PF02603.16 ETO22292.1 - 0.048 13.7 0.0 0.08 13.0 0.0 1.3 1 0 0 1 1 1 0 HPr Serine kinase N terminus adh_short PF00106.25 ETO22293.1 - 1.5e-07 31.1 0.0 0.00076 19.0 0.0 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO22293.1 - 0.00029 20.5 0.0 0.013 15.0 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase HAD_2 PF13419.6 ETO22294.1 - 0.0039 17.3 0.0 0.014 15.5 0.0 1.9 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Acid_PPase PF12689.7 ETO22294.1 - 0.0093 15.8 0.0 0.036 13.9 0.0 1.9 1 1 0 1 1 1 1 Acid Phosphatase DUF4764 PF15961.5 ETO22294.1 - 0.018 13.8 3.6 0.024 13.4 3.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4764) Rota_VP2 PF05087.12 ETO22294.1 - 0.7 7.9 10.5 1 7.4 10.5 1.2 1 0 0 1 1 1 0 Rotavirus VP2 protein Zip PF02535.22 ETO22294.1 - 1 8.5 9.3 1.4 8.0 9.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 ETO22294.1 - 4.3 6.1 7.2 5.4 5.7 7.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Menin PF05053.13 ETO22294.1 - 6.8 4.9 10.7 9.7 4.4 10.7 1.3 1 0 0 1 1 1 0 Menin Kelch_6 PF13964.6 ETO22295.1 - 0.054 13.8 0.1 0.16 12.3 0.1 1.8 1 0 0 1 1 1 0 Kelch motif DUF1981 PF09324.10 ETO22296.1 - 1.5e-23 82.4 2.2 1.5e-23 82.4 2.2 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) FPL PF09758.9 ETO22296.1 - 0.087 12.8 2.6 0.15 12.1 0.6 2.2 2 1 0 2 2 2 0 Uncharacterised conserved protein DUF4975 PF16346.5 ETO22297.1 - 0.073 13.2 0.0 0.11 12.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4975) Sec7_N PF12783.7 ETO22298.1 - 5.6e-30 104.3 2.7 1.2e-29 103.3 0.6 1.9 1 1 1 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal PPL5 PF18168.1 ETO22299.1 - 1.6 7.9 7.4 2.4 7.4 7.4 1.3 1 0 0 1 1 1 0 Prim-pol family 5 AAA_18 PF13238.6 ETO22300.1 - 0.00012 22.7 0.0 0.0011 19.5 0.0 2.6 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ETO22300.1 - 0.0014 18.6 0.0 0.0075 16.2 0.0 2.2 2 0 0 2 2 2 1 NACHT domain AAA_22 PF13401.6 ETO22300.1 - 0.0033 17.7 0.0 0.013 15.8 0.0 2.0 1 0 0 1 1 1 1 AAA domain ATPase PF06745.13 ETO22300.1 - 0.016 14.6 1.3 1.4 8.2 0.0 3.1 3 0 0 3 3 3 0 KaiC RNA_helicase PF00910.22 ETO22300.1 - 0.043 14.2 0.0 0.2 12.1 0.0 2.2 1 0 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 ETO22300.1 - 0.079 13.5 0.0 0.36 11.3 0.0 2.2 1 0 0 1 1 1 0 ABC transporter TsaE PF02367.17 ETO22300.1 - 0.085 12.9 0.0 0.29 11.2 0.0 1.8 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ETO22300.1 - 0.092 12.4 0.0 0.35 10.6 0.0 2.0 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_33 PF13671.6 ETO22300.1 - 0.11 12.7 0.0 0.37 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA domain DUF1610 PF07754.11 ETO22300.1 - 0.35 10.9 3.5 0.69 9.9 3.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1610) DIE2_ALG10 PF04922.12 ETO22301.1 - 9.3e-26 91.0 12.8 9.3e-26 91.0 12.8 1.9 2 0 0 2 2 2 1 DIE2/ALG10 family DUF1772 PF08592.11 ETO22301.1 - 0.011 16.0 0.2 0.023 15.0 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) DUF1748 PF08520.10 ETO22301.1 - 0.12 12.3 0.0 0.22 11.5 0.0 1.4 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF1748) DAGK_acc PF00609.19 ETO22302.1 - 4.8e-19 69.2 0.1 2.6e-18 66.8 0.0 2.2 2 0 0 2 2 2 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ETO22302.1 - 1.7e-13 50.3 0.0 3.1e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF3537 PF12056.8 ETO22302.1 - 0.08 11.7 0.8 0.21 10.4 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3537) ANAPC10 PF03256.16 ETO22303.1 - 3.7e-53 179.9 0.4 4.7e-53 179.6 0.4 1.0 1 0 0 1 1 1 1 Anaphase-promoting complex, subunit 10 (APC10) PITH PF06201.13 ETO22303.1 - 0.016 15.5 0.0 0.051 13.8 0.0 1.7 1 1 1 2 2 2 0 PITH domain F5_F8_type_C PF00754.25 ETO22303.1 - 0.021 14.9 0.1 0.054 13.6 0.1 1.8 2 0 0 2 2 2 0 F5/8 type C domain Arm PF00514.23 ETO22304.1 - 2.7e-17 62.1 5.1 0.0094 16.0 0.3 6.4 6 0 0 6 6 6 5 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO22304.1 - 6.2e-05 23.4 0.1 0.015 15.8 0.0 2.9 2 0 0 2 2 2 1 HEAT-like repeat HEAT_2 PF13646.6 ETO22304.1 - 0.0073 16.7 0.0 4.8 7.6 0.0 2.6 2 1 0 2 2 2 2 HEAT repeats DUF4611 PF15387.6 ETO22304.1 - 0.011 16.0 1.5 0.025 14.8 1.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) TFB6 PF17110.5 ETO22304.1 - 0.05 13.3 0.4 0.26 11.0 0.1 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH HEAT PF02985.22 ETO22304.1 - 0.23 11.8 0.7 62 4.3 0.0 3.4 3 0 0 3 3 3 0 HEAT repeat Ribosomal_60s PF00428.19 ETO22304.1 - 5.4 7.7 9.7 18 6.0 9.7 1.8 1 0 0 1 1 1 0 60s Acidic ribosomal protein Dicty_REP PF05086.12 ETO22305.1 - 0.019 13.0 9.5 0.012 13.6 7.8 1.6 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO22305.1 - 0.71 9.8 8.3 1.8 8.6 8.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO22305.1 - 1.4 8.9 14.7 0.091 12.8 9.0 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein TFIIF_alpha PF05793.12 ETO22306.1 - 0.059 12.0 25.7 0.077 11.6 25.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mpp10 PF04006.12 ETO22306.1 - 0.076 11.4 26.8 0.1 11.0 26.8 1.1 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 ETO22306.1 - 0.088 11.0 21.0 0.12 10.5 21.0 1.1 1 0 0 1 1 1 0 Nop14-like family Afi1 PF07792.12 ETO22306.1 - 0.27 11.7 12.0 0.68 10.4 12.0 1.7 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CDC45 PF02724.14 ETO22306.1 - 0.97 7.6 21.6 1.3 7.2 21.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO22306.1 - 1 9.7 22.6 1.8 8.9 22.6 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RR_TM4-6 PF06459.12 ETO22306.1 - 1.3 8.7 15.1 1.9 8.2 15.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4604 PF15377.6 ETO22306.1 - 2.6 8.4 20.9 3.7 8.0 20.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) DUF913 PF06025.12 ETO22306.1 - 4.7 6.1 6.2 7.7 5.4 6.2 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO22306.1 - 5.3 6.2 4.5 8 5.6 4.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 ETO22306.1 - 6.5 6.1 26.8 9.8 5.5 26.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Ion_trans PF00520.31 ETO22307.1 - 8.8e-21 74.2 65.4 9.9e-20 70.8 21.5 3.9 3 1 1 4 4 4 3 Ion transport protein EF-hand_6 PF13405.6 ETO22307.1 - 0.0012 18.6 0.9 1.1 9.4 0.5 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO22307.1 - 0.0054 17.2 0.8 0.13 12.7 0.2 2.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO22307.1 - 0.0084 15.6 2.0 2 8.2 1.0 2.7 2 0 0 2 2 2 2 EF hand DUF1744 PF08490.12 ETO22308.1 - 2.6e-21 75.7 0.7 2.8e-21 75.6 0.7 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1744) UCH PF00443.29 ETO22309.1 - 3.6e-06 26.7 0.0 5.9e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Drf_FH3 PF06367.16 ETO22310.1 - 0.061 12.9 4.9 0.21 11.2 2.9 2.0 1 1 1 2 2 2 0 Diaphanous FH3 Domain FKBP_N PF01346.18 ETO22310.1 - 0.25 12.3 4.6 3.8 8.5 0.8 2.2 2 0 0 2 2 2 0 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase DUF3450 PF11932.8 ETO22310.1 - 0.81 8.9 5.9 0.35 10.1 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Surp PF01805.20 ETO22312.1 - 7.4e-06 25.9 0.0 1.6e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Surp module Renin_r PF07850.14 ETO22312.1 - 0.53 10.9 4.6 1.3 9.7 4.6 1.7 1 1 0 1 1 1 0 Renin receptor-like protein Shisa PF13908.6 ETO22312.1 - 0.64 10.2 3.4 0.85 9.8 3.4 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CDC45 PF02724.14 ETO22312.1 - 3.5 5.8 10.8 4.2 5.5 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein PRP38_assoc PF12871.7 ETO22312.1 - 7 7.3 46.0 60 4.3 45.9 2.2 1 1 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term DUF1523 PF07509.11 ETO22313.1 - 0.048 13.0 0.0 0.08 12.3 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) Herpes_UL6 PF01763.16 ETO22313.1 - 0.26 9.7 5.1 0.36 9.3 5.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like GREB1 PF15782.5 ETO22313.1 - 1.2 6.2 13.5 1.5 5.8 13.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer U1snRNP70_N PF12220.8 ETO22313.1 - 2.3 8.9 17.3 0.95 10.1 1.6 3.0 3 0 0 3 3 3 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal APG6_N PF17675.1 ETO22313.1 - 5.3 7.6 16.1 0.29 11.7 10.4 1.7 2 0 0 2 2 2 0 Apg6 coiled-coil region HhH-GPD PF00730.25 ETO22314.1 - 0.0099 16.3 0.5 0.036 14.5 0.5 2.1 1 1 0 1 1 1 1 HhH-GPD superfamily base excision DNA repair protein CDC27 PF09507.10 ETO22314.1 - 0.39 10.0 34.2 0.45 9.9 34.2 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Presenilin PF01080.17 ETO22314.1 - 1.1 8.0 19.9 1.2 7.9 19.9 1.1 1 0 0 1 1 1 0 Presenilin Velvet PF11754.8 ETO22314.1 - 1.8 8.5 8.9 2.4 8.0 8.9 1.3 1 0 0 1 1 1 0 Velvet factor Endostatin PF06482.11 ETO22314.1 - 2.1 7.7 11.8 2.4 7.5 11.8 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DUF4407 PF14362.6 ETO22314.1 - 2.6 7.3 12.2 2.9 7.2 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM60A PF15396.6 ETO22314.1 - 3.3 7.7 18.3 3.8 7.4 18.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A FancD2 PF14631.6 ETO22314.1 - 3.5 4.9 15.8 3.8 4.8 15.8 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease HNF-1_N PF04814.13 ETO22314.1 - 3.8 8.1 17.9 0.87 10.2 15.2 1.3 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus DUF2981 PF11200.8 ETO22314.1 - 4 7.1 11.7 4.4 7.0 11.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SAPS PF04499.15 ETO22314.1 - 7.8 5.1 16.2 8.8 5.0 16.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein RGS PF00615.19 ETO22315.1 - 0.0022 18.3 0.4 0.0025 18.1 0.4 1.3 1 1 0 1 1 1 1 Regulator of G protein signaling domain Orthopox_35kD PF02250.15 ETO22315.1 - 0.057 13.1 0.1 0.069 12.8 0.1 1.1 1 0 0 1 1 1 0 35kD major secreted virus protein AAA_12 PF13087.6 ETO22317.1 - 7.5e-35 120.4 0.0 1.6e-34 119.3 0.0 1.4 2 0 0 2 2 2 1 AAA domain Radial_spoke_3 PF06098.11 ETO22318.1 - 3.9e-28 98.6 14.8 1.2e-27 96.9 14.8 1.7 1 1 0 1 1 1 1 Radial spoke protein 3 DZR PF12773.7 ETO22318.1 - 0.15 12.1 0.2 0.34 11.0 0.2 1.5 1 0 0 1 1 1 0 Double zinc ribbon LpoB PF13036.6 ETO22318.1 - 0.21 11.5 4.7 0.12 12.3 1.3 2.3 2 0 0 2 2 2 0 Peptidoglycan-synthase activator LpoB MMR_HSR1_Xtn PF16897.5 ETO22318.1 - 1.6 8.8 7.7 0.89 9.6 2.1 2.9 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain Leg1 PF05612.12 ETO22319.1 - 0.013 14.7 0.2 0.024 13.8 0.2 1.4 1 0 0 1 1 1 0 Leg1 DUF2523 PF10734.9 ETO22319.1 - 0.023 15.2 0.9 9.6 6.9 0.0 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2523) Nop PF01798.18 ETO22319.1 - 0.16 11.4 0.0 0.25 10.8 0.0 1.2 1 0 0 1 1 1 0 snoRNA binding domain, fibrillarin Ion_trans PF00520.31 ETO22320.1 - 1.1e-88 296.6 53.1 2.6e-35 121.8 6.3 4.1 4 0 0 4 4 4 4 Ion transport protein PKD_channel PF08016.12 ETO22320.1 - 2.4e-06 26.5 12.6 2.4e-06 26.5 12.6 6.1 5 2 2 7 7 7 4 Polycystin cation channel Mucin PF01456.17 ETO22321.1 - 0.0024 17.9 2.9 0.0024 17.9 2.9 2.3 2 0 0 2 2 2 1 Mucin-like glycoprotein Mid2 PF04478.12 ETO22321.1 - 0.0033 17.3 6.8 0.0087 15.9 0.1 2.6 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor TrmE_N PF10396.9 ETO22321.1 - 0.023 15.0 0.5 2.3 8.6 0.1 2.3 2 0 0 2 2 2 0 GTP-binding protein TrmE N-terminus Kelch_6 PF13964.6 ETO22321.1 - 0.031 14.6 0.0 0.2 12.0 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Adeno_E3_CR2 PF02439.15 ETO22321.1 - 0.048 13.4 0.7 0.048 13.4 0.7 1.9 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 DUF3439 PF11921.8 ETO22321.1 - 0.054 13.5 4.6 0.15 12.0 4.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Phage_holin_2_4 PF16082.5 ETO22321.1 - 0.065 13.0 1.4 0.12 12.2 0.1 2.0 2 0 0 2 2 2 0 Bacteriophage holin family, superfamily II-like Ninjurin PF04923.12 ETO22321.1 - 0.081 12.9 0.4 0.15 12.0 0.4 1.4 1 0 0 1 1 1 0 Ninjurin GSG-1 PF07803.11 ETO22321.1 - 1.4 8.9 3.7 0.58 10.1 0.2 2.2 3 0 0 3 3 3 0 GSG1-like protein SLATT_1 PF18181.1 ETO22323.1 - 0.057 13.4 0.0 0.083 12.8 0.0 1.3 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain 1 SPC22 PF04573.12 ETO22323.1 - 0.084 12.4 0.7 0.13 11.7 0.1 1.5 2 0 0 2 2 2 0 Signal peptidase subunit MAP65_ASE1 PF03999.12 ETO22323.1 - 0.14 10.8 14.9 0.17 10.5 14.9 1.1 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Porin_4 PF13609.6 ETO22324.1 - 0.00015 21.6 1.5 0.00022 21.1 1.5 1.4 1 0 0 1 1 1 1 Gram-negative porin OmpA_membrane PF01389.17 ETO22324.1 - 0.021 14.5 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 OmpA-like transmembrane domain OMP_b-brl PF13505.6 ETO22324.1 - 0.031 14.4 10.9 0.047 13.8 6.5 2.8 1 1 0 2 2 2 0 Outer membrane protein beta-barrel domain vATP-synt_AC39 PF01992.16 ETO22325.1 - 2.8e-21 76.4 2.0 7.1e-17 61.9 0.7 2.2 2 0 0 2 2 2 2 ATP synthase (C/AC39) subunit DUF1548 PF07579.11 ETO22326.1 - 0.044 14.1 0.6 0.073 13.4 0.6 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1548) ZZ PF00569.17 ETO22326.1 - 0.48 10.3 7.7 2.1 8.2 7.7 1.9 1 1 0 1 1 1 0 Zinc finger, ZZ type DUF4428 PF14471.6 ETO22326.1 - 2.8 7.9 11.0 7.7 6.5 6.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) LRR_8 PF13855.6 ETO22328.1 - 1.7e-20 72.5 34.7 1.6e-09 37.3 10.9 6.2 1 1 6 7 7 7 7 Leucine rich repeat LRR_4 PF12799.7 ETO22328.1 - 2.4e-18 65.9 37.5 0.00022 21.5 4.7 7.8 2 1 4 8 8 8 7 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO22328.1 - 5.8e-05 23.1 33.8 0.11 13.1 0.3 11.3 10 3 3 13 13 13 2 Leucine Rich Repeat LRRNT_2 PF08263.12 ETO22328.1 - 0.00074 19.8 0.8 0.0017 18.6 0.8 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain DUF5612 PF18462.1 ETO22328.1 - 0.11 12.3 0.0 3.4 7.5 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF5612) LRR_4 PF12799.7 ETO22329.1 - 7e-07 29.5 30.2 0.00047 20.5 2.0 5.2 4 1 3 7 7 7 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO22329.1 - 1.4e-05 24.7 37.6 4.9e-05 23.0 2.5 5.0 5 1 1 6 6 6 3 Leucine rich repeat LRR_9 PF14580.6 ETO22329.1 - 0.19 11.2 6.2 3.1 7.3 0.1 2.5 1 1 1 2 2 2 0 Leucine-rich repeat IF-2B PF01008.17 ETO22330.1 - 2.1e-16 60.0 0.4 8e-14 51.5 0.0 2.2 2 0 0 2 2 2 2 Initiation factor 2 subunit family Symplekin_C PF12295.8 ETO22330.1 - 0.017 15.2 0.0 0.032 14.3 0.0 1.4 1 0 0 1 1 1 0 Symplekin tight junction protein C terminal SfsA_N PF17746.1 ETO22331.1 - 0.039 14.1 0.3 7 6.9 0.0 2.7 2 1 1 3 3 3 0 SfsA N-terminal OB domain DUF569 PF04601.13 ETO22331.1 - 0.045 13.4 0.1 0.08 12.6 0.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF569) PRIMA1 PF16101.5 ETO22331.1 - 0.073 13.1 5.6 0.15 12.1 5.6 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF2306 PF10067.9 ETO22332.1 - 0.081 13.1 3.2 0.18 12.0 0.3 2.6 1 1 0 2 2 2 0 Predicted membrane protein (DUF2306) RE_HaeIII PF09556.10 ETO22332.1 - 0.13 11.3 3.7 1.4 7.9 0.3 2.4 2 0 0 2 2 2 0 HaeIII restriction endonuclease BTB PF00651.31 ETO22333.1 - 7.5e-12 45.5 0.1 1.8e-11 44.2 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ETO22333.1 - 0.026 14.6 3.3 1.9 8.6 1.0 3.3 3 0 0 3 3 3 0 BTB And C-terminal Kelch Presenilin PF01080.17 ETO22333.1 - 0.91 8.2 3.1 1.4 7.6 3.1 1.2 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 ETO22333.1 - 0.97 10.0 12.9 2 9.0 12.9 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 ETO22333.1 - 3.7 5.8 7.8 5.6 5.2 7.8 1.2 1 0 0 1 1 1 0 Menin NOA36 PF06524.12 ETO22333.1 - 5.5 6.2 19.8 15 4.8 19.8 1.7 1 0 0 1 1 1 0 NOA36 protein IstB_IS21 PF01695.17 ETO22336.1 - 0.056 13.2 0.0 0.16 11.7 0.0 1.8 1 0 0 1 1 1 0 IstB-like ATP binding protein DUF445 PF04286.12 ETO22338.1 - 3.2e-07 30.5 0.9 0.0051 16.7 0.0 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF445) Phtf-FEM1B_bdg PF12129.8 ETO22338.1 - 0.0073 16.1 0.0 0.017 14.9 0.0 1.6 1 0 0 1 1 1 1 Male germ-cell putative homeodomain transcription factor Holin_BhlA PF10960.8 ETO22338.1 - 0.099 12.6 2.4 0.11 12.4 0.3 2.1 2 0 0 2 2 2 0 BhlA holin family Menin PF05053.13 ETO22340.1 - 2.7 6.2 18.5 3.8 5.7 18.5 1.2 1 0 0 1 1 1 0 Menin Exonuc_VII_L PF02601.15 ETO22341.1 - 0.47 10.0 13.5 0.68 9.5 13.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4200 PF13863.6 ETO22341.1 - 3.1 8.2 38.3 0.27 11.6 23.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) ApoO PF09769.9 ETO22341.1 - 3.4 7.7 7.8 1.1 9.3 2.7 2.2 2 0 0 2 2 2 0 Apolipoprotein O YtxH PF12732.7 ETO22341.1 - 4 8.0 11.2 86 3.8 10.2 2.7 1 1 0 1 1 1 0 YtxH-like protein Med21 PF11221.8 ETO22342.1 - 0.036 14.3 1.1 0.088 13.1 1.1 1.8 1 1 0 1 1 1 0 Subunit 21 of Mediator complex DUF641 PF04859.12 ETO22342.1 - 0.045 14.1 1.2 0.098 13.0 1.2 1.6 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) RIG-I_C-RD PF11648.8 ETO22342.1 - 0.067 13.4 0.2 0.51 10.6 0.1 2.1 2 0 0 2 2 2 0 C-terminal domain of RIG-I Macoilin PF09726.9 ETO22342.1 - 0.094 11.3 20.9 0.12 10.9 20.9 1.0 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO22342.1 - 0.27 9.5 13.7 0.31 9.3 13.7 1.2 1 0 0 1 1 1 0 Menin Castor1_N PF18700.1 ETO22342.1 - 0.33 10.8 1.7 0.59 10.0 1.7 1.4 1 0 0 1 1 1 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain SOG2 PF10428.9 ETO22342.1 - 0.45 9.7 14.4 0.56 9.3 14.4 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein DUF5383 PF17355.2 ETO22342.1 - 4.5 7.7 7.7 0.13 12.6 0.7 2.0 2 1 0 2 2 2 0 Family of unknown function (DUF5383) ASD2 PF08687.11 ETO22342.1 - 6.2 6.3 10.7 33 3.9 10.7 2.0 1 1 0 1 1 1 0 Apx/Shroom domain ASD2 Tmemb_9 PF05434.11 ETO22342.1 - 6.2 6.7 8.1 0.46 10.4 1.1 2.3 2 0 0 2 2 2 0 TMEM9 CHAT PF12770.7 ETO22343.1 - 1.4e-07 31.3 0.0 7e-07 28.9 0.0 1.7 1 1 0 1 1 1 1 CHAT domain NACHT PF05729.12 ETO22343.1 - 0.00062 19.7 0.0 0.0022 18.0 0.0 2.0 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO22343.1 - 0.037 14.4 0.3 0.18 12.2 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain Ion_trans PF00520.31 ETO22344.1 - 4e-39 134.3 14.8 5.9e-39 133.8 14.8 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO22344.1 - 1.6e-05 23.8 12.4 3.8e-05 22.6 12.4 1.6 1 1 0 1 1 1 1 Polycystin cation channel GPHH PF16905.5 ETO22344.1 - 0.031 14.0 0.4 1.6 8.6 0.0 2.5 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated DUF2189 PF09955.9 ETO22344.1 - 0.5 10.6 4.0 3.4 7.9 4.3 2.1 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) Ycf66_N PF07444.11 ETO22344.1 - 1.4 9.1 7.9 12 6.1 0.0 3.7 4 0 0 4 4 4 0 Ycf66 protein N-terminus CdiI_3 PF18616.1 ETO22346.1 - 0.019 14.8 0.0 0.059 13.3 0.0 1.8 1 0 0 1 1 1 0 CDI immunity proteins Glypican PF01153.19 ETO22346.1 - 0.36 9.6 4.3 0.49 9.2 4.3 1.1 1 0 0 1 1 1 0 Glypican Arm_3 PF16186.5 ETO22347.1 - 0.0002 20.8 0.3 0.0004 19.9 0.3 1.5 1 0 0 1 1 1 1 Atypical Arm repeat Arm PF00514.23 ETO22347.1 - 0.0067 16.4 0.6 0.061 13.4 0.0 2.5 2 1 0 2 2 2 1 Armadillo/beta-catenin-like repeat Arm PF00514.23 ETO22348.1 - 6.6e-12 45.0 5.2 3.5e-05 23.7 0.4 4.0 3 0 0 3 3 3 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO22348.1 - 0.15 12.6 0.1 20 5.8 0.0 3.2 2 1 1 3 3 3 0 HEAT-like repeat zf-TRAF PF02176.18 ETO22349.1 - 5.4e-05 23.8 0.2 5.4e-05 23.8 0.2 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger APG6 PF04111.12 ETO22350.1 - 9.7e-38 129.9 0.0 1.5e-37 129.3 0.0 1.2 1 0 0 1 1 1 1 Apg6 BARA domain APG6_N PF17675.1 ETO22350.1 - 7.4e-06 26.5 9.8 1.1e-05 25.9 9.8 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF1664 PF07889.12 ETO22350.1 - 0.00012 22.1 2.5 0.0002 21.4 2.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) YabA PF06156.13 ETO22350.1 - 0.0016 19.0 2.4 0.0035 18.0 2.4 1.5 1 0 0 1 1 1 1 Initiation control protein YabA HAP1_N PF04849.13 ETO22350.1 - 0.0054 16.0 6.8 0.0084 15.3 6.8 1.2 1 0 0 1 1 1 1 HAP1 N-terminal conserved region ZapB PF06005.12 ETO22350.1 - 0.034 14.6 6.8 0.072 13.5 6.8 1.6 1 0 0 1 1 1 0 Cell division protein ZapB ALIX_LYPXL_bnd PF13949.6 ETO22350.1 - 0.055 12.8 0.1 0.055 12.8 0.1 1.9 1 1 1 2 2 2 0 ALIX V-shaped domain binding to HIV FapA PF03961.13 ETO22350.1 - 0.059 12.0 0.9 0.079 11.5 0.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A Uso1_p115_C PF04871.13 ETO22350.1 - 0.066 13.6 2.7 0.1 13.0 2.7 1.3 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Seryl_tRNA_N PF02403.22 ETO22350.1 - 0.093 13.0 2.3 0.17 12.2 2.3 1.4 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.9 ETO22350.1 - 0.17 11.9 10.2 1.5 8.9 9.8 2.4 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Jnk-SapK_ap_N PF09744.9 ETO22350.1 - 0.19 11.9 7.6 0.31 11.3 7.6 1.3 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 THOC7 PF05615.13 ETO22350.1 - 0.2 11.9 5.1 0.4 11.0 5.1 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 FlaC_arch PF05377.11 ETO22350.1 - 0.28 11.6 2.8 5 7.6 0.4 2.7 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 ETO22350.1 - 0.32 9.8 6.3 0.44 9.4 6.3 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Snapin_Pallidin PF14712.6 ETO22350.1 - 0.56 10.7 5.6 1.2 9.6 5.6 1.6 1 1 0 1 1 1 0 Snapin/Pallidin UPF0242 PF06785.11 ETO22350.1 - 1.1 9.3 8.1 2 8.5 8.1 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 ETO22350.1 - 1.2 8.9 6.0 0.94 9.3 2.3 2.2 2 0 0 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 ETO22350.1 - 3.4 7.8 7.6 2.2 8.4 4.3 2.3 2 0 0 2 2 2 0 bZIP transcription factor DUF4140 PF13600.6 ETO22350.1 - 6.4 7.3 6.0 12 6.4 1.9 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) AMP-binding PF00501.28 ETO22351.1 - 2.7e-24 85.6 0.3 5.4e-11 41.7 0.0 2.6 2 1 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ETO22351.1 - 5.8e-20 72.1 0.2 1.1e-19 71.2 0.2 1.5 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain DENN PF02141.21 ETO22352.1 - 0.014 15.4 0.1 0.031 14.2 0.1 1.6 1 0 0 1 1 1 0 DENN (AEX-3) domain ENTH PF01417.20 ETO22352.1 - 0.015 15.3 0.9 0.045 13.8 0.1 2.3 2 0 0 2 2 2 0 ENTH domain H_lectin PF09458.10 ETO22352.1 - 0.58 10.4 6.3 11 6.3 2.8 2.8 2 0 0 2 2 2 0 H-type lectin domain DUF4979 PF16351.5 ETO22353.1 - 0.026 14.8 0.6 0.044 14.0 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4979) AAA_22 PF13401.6 ETO22355.1 - 0.00049 20.4 0.0 0.0016 18.8 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETO22355.1 - 0.03 14.1 0.0 0.051 13.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_9 PF12781.7 ETO22355.1 - 0.06 12.5 0.2 0.39 9.8 0.0 2.1 2 0 0 2 2 2 0 ATP-binding dynein motor region TMEM126 PF07114.11 ETO22355.1 - 0.062 12.7 0.1 0.12 11.8 0.1 1.4 1 0 0 1 1 1 0 Transmembrane protein 126 AAA PF00004.29 ETO22355.1 - 0.1 13.1 0.0 0.22 12.0 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO22355.1 - 0.15 11.5 0.3 0.49 9.9 0.3 1.9 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_8 PF12780.7 ETO22356.1 - 1.9e-06 27.4 0.1 3.5e-06 26.6 0.1 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA PF00004.29 ETO22356.1 - 7.5e-06 26.4 0.3 1.2e-05 25.8 0.3 1.7 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO22356.1 - 1.8e-05 24.8 0.1 4.3e-05 23.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO22356.1 - 6.7e-05 22.5 0.1 0.00012 21.6 0.1 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region ABC_tran PF00005.27 ETO22356.1 - 0.00023 21.7 0.3 0.00035 21.1 0.3 1.4 1 1 0 1 1 1 1 ABC transporter Mg_chelatase PF01078.21 ETO22356.1 - 0.0039 16.6 0.0 2 7.7 0.0 2.2 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ETO22356.1 - 0.0048 16.9 2.0 0.0066 16.5 0.0 2.2 2 1 1 3 3 3 1 AAA domain MCM PF00493.23 ETO22356.1 - 0.0072 15.4 0.1 0.02 14.0 0.1 1.7 2 0 0 2 2 2 1 MCM P-loop domain AAA_16 PF13191.6 ETO22356.1 - 0.01 16.2 0.1 0.19 12.1 0.0 2.2 2 1 1 3 3 3 0 AAA ATPase domain Rad17 PF03215.15 ETO22356.1 - 0.016 15.1 0.6 0.41 10.5 0.2 2.1 1 1 0 2 2 2 0 Rad17 P-loop domain AAA_23 PF13476.6 ETO22356.1 - 0.018 15.5 1.4 0.037 14.5 1.4 1.6 1 1 0 1 1 1 0 AAA domain DUF815 PF05673.13 ETO22356.1 - 0.023 13.8 0.1 0.032 13.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) Sigma54_activat PF00158.26 ETO22356.1 - 0.043 13.5 0.1 0.16 11.6 0.0 1.8 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_22 PF13401.6 ETO22356.1 - 0.056 13.7 0.7 0.18 12.1 0.7 1.9 1 1 0 1 1 1 0 AAA domain baeRF_family3 PF18845.1 ETO22356.1 - 0.14 12.4 0.1 0.23 11.7 0.1 1.4 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 3 NACHT PF05729.12 ETO22356.1 - 0.17 11.8 0.3 0.48 10.3 0.2 1.8 2 0 0 2 2 2 0 NACHT domain RNA_helicase PF00910.22 ETO22356.1 - 0.18 12.2 0.4 0.52 10.7 0.2 1.9 1 1 0 1 1 1 0 RNA helicase AAA_2 PF07724.14 ETO22356.1 - 0.2 11.7 0.6 1.5 8.9 0.0 2.4 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) ATP-synt_ab PF00006.25 ETO22356.1 - 0.25 11.0 0.2 0.45 10.1 0.2 1.4 1 1 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain SMC_N PF02463.19 ETO22356.1 - 0.3 10.5 1.6 1.2 8.6 0.1 2.3 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain ATPase_2 PF01637.18 ETO22356.1 - 0.36 10.7 2.9 0.42 10.5 0.2 2.3 2 1 1 3 3 3 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ETO22356.1 - 0.43 10.3 3.1 0.57 9.9 0.6 2.2 1 1 0 2 2 2 0 AAA domain HSP70 PF00012.20 ETO22357.1 - 1.2e-48 165.8 0.4 1.2e-48 165.8 0.4 1.7 2 0 0 2 2 2 1 Hsp70 protein MreB_Mbl PF06723.13 ETO22357.1 - 2.7e-09 36.3 0.6 4.5e-09 35.6 0.6 1.3 1 0 0 1 1 1 1 MreB/Mbl protein DUF1908 PF08926.11 ETO22357.1 - 0.054 12.6 0.2 0.11 11.6 0.2 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1908) MLTR_LBD PF17765.1 ETO22358.1 - 0.017 15.2 1.5 0.023 14.8 1.5 1.1 1 0 0 1 1 1 0 MmyB-like transcription regulator ligand binding domain MetOD1 PF18546.1 ETO22358.1 - 0.39 10.7 2.5 0.68 9.9 2.5 1.5 1 1 0 1 1 1 0 Metanogen output domain 1 Alkyl_sulf_dimr PF14863.6 ETO22360.1 - 7.1e-09 36.2 0.1 1.2e-08 35.5 0.1 1.4 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Alkyl_sulf_C PF14864.6 ETO22360.1 - 0.00018 21.8 0.0 0.0079 16.5 0.0 2.7 3 0 0 3 3 3 1 Alkyl sulfatase C-terminal Conotoxin PF02950.17 ETO22361.1 - 0.057 14.4 0.2 0.24 12.4 0.2 2.1 1 0 0 1 1 1 0 Conotoxin TMEM171 PF15471.6 ETO22361.1 - 0.32 10.0 3.4 0.49 9.3 3.4 1.2 1 0 0 1 1 1 0 Transmembrane protein family 171 Zip PF02535.22 ETO22361.1 - 6.9 5.8 21.1 5.5 6.1 20.0 1.4 1 1 0 1 1 1 0 ZIP Zinc transporter BRAP2 PF07576.12 ETO22363.1 - 1e-16 61.0 0.7 2.3e-16 59.8 0.7 1.6 1 0 0 1 1 1 1 BRCA1-associated protein 2 zf-UBP PF02148.19 ETO22363.1 - 1.7e-16 60.3 8.5 1.7e-16 60.3 8.5 2.7 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein zf-RING_2 PF13639.6 ETO22363.1 - 3.9e-06 27.1 1.4 3.9e-06 27.1 1.4 3.3 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO22363.1 - 9.3e-06 25.4 1.7 9.3e-06 25.4 1.7 3.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO22363.1 - 3.8e-05 23.5 3.9 3.8e-05 23.5 3.9 3.0 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ETO22363.1 - 4.3e-05 23.4 1.6 4.3e-05 23.4 1.6 3.1 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETO22363.1 - 0.01 15.6 0.5 0.01 15.6 0.5 4.0 4 1 1 5 5 5 0 RING-like zinc finger RRM_1 PF00076.22 ETO22363.1 - 0.05 13.4 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CENP-B_dimeris PF09026.10 ETO22365.1 - 0.088 13.2 7.7 2.4 8.6 0.0 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 ETO22365.1 - 6.3 6.5 9.0 3.5 7.4 0.7 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein FMO-like PF00743.19 ETO22366.1 - 4.4e-15 55.1 0.0 5.5e-15 54.8 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like NAD_binding_8 PF13450.6 ETO22366.1 - 2.6e-06 27.6 0.0 4.3e-06 26.9 0.0 1.4 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETO22366.1 - 0.00061 19.5 0.0 0.0022 17.7 0.0 1.7 1 1 1 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO22366.1 - 0.0027 17.0 0.0 0.0027 17.0 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO22366.1 - 0.003 16.9 0.1 0.035 13.3 0.1 2.0 1 1 1 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETO22366.1 - 0.015 14.6 0.0 0.021 14.1 0.0 1.1 1 0 0 1 1 1 0 Thi4 family K_oxygenase PF13434.6 ETO22366.1 - 0.023 13.9 0.2 3.6 6.6 0.0 2.2 2 0 0 2 2 2 0 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_2 PF00890.24 ETO22366.1 - 0.027 13.5 0.1 0.036 13.2 0.1 1.1 1 0 0 1 1 1 0 FAD binding domain NAD_binding_9 PF13454.6 ETO22366.1 - 0.034 14.1 0.1 0.052 13.5 0.0 1.6 1 1 0 1 1 1 0 FAD-NAD(P)-binding Pyr_redox PF00070.27 ETO22366.1 - 0.037 14.6 0.0 0.068 13.7 0.0 1.4 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ETO22366.1 - 0.037 13.3 0.0 0.052 12.8 0.0 1.2 1 0 0 1 1 1 0 Flavin containing amine oxidoreductase FAD_binding_3 PF01494.19 ETO22366.1 - 0.17 11.1 0.0 0.24 10.6 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain FMO-like PF00743.19 ETO22367.1 - 3.3e-06 25.8 0.0 3.9e-06 25.6 0.0 1.0 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETO22368.1 - 0.0001 21.7 0.0 0.0001 21.7 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ETO22368.1 - 0.0015 17.0 0.0 0.0015 17.0 0.0 1.1 1 0 0 1 1 1 1 Flavin-binding monooxygenase-like Shikimate_DH PF01488.20 ETO22368.1 - 0.011 15.8 0.0 0.013 15.6 0.0 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Pyr_redox_3 PF13738.6 ETO22368.1 - 0.061 12.6 0.0 0.084 12.1 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO22368.1 - 0.097 13.2 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Aldo_ket_red PF00248.21 ETO22369.1 - 8.7e-16 58.0 0.1 9.8e-16 57.8 0.1 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family DUF2164 PF09932.9 ETO22369.1 - 0.11 12.5 0.2 0.88 9.7 0.0 2.2 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) Aldo_ket_red PF00248.21 ETO22370.1 - 2.3e-27 96.0 0.1 2.9e-27 95.6 0.1 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family F-box PF00646.33 ETO22371.1 - 3.6e-07 29.9 0.8 6.7e-07 29.0 0.8 1.4 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO22371.1 - 7e-05 22.6 0.9 0.00015 21.6 0.9 1.5 1 0 0 1 1 1 1 F-box-like CDC45 PF02724.14 ETO22371.1 - 0.0021 16.5 4.1 0.0021 16.5 4.1 1.4 2 0 0 2 2 2 1 CDC45-like protein DUF3306 PF11748.8 ETO22371.1 - 0.028 15.3 8.4 8 7.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Borrelia_P83 PF05262.11 ETO22371.1 - 0.051 12.1 8.9 0.077 11.5 8.9 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein PEHE PF15275.6 ETO22371.1 - 0.22 12.2 9.7 0.11 13.1 5.0 2.2 2 0 0 2 2 2 0 PEHE domain Connexin PF00029.19 ETO22371.1 - 0.76 9.5 7.3 0.046 13.5 1.7 1.9 2 0 0 2 2 2 0 Connexin RR_TM4-6 PF06459.12 ETO22371.1 - 1.4 8.7 13.1 0.4 10.5 9.1 1.8 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Pex14_N PF04695.13 ETO22371.1 - 2.4 8.8 19.7 0.12 13.1 13.1 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TERB2 PF15101.6 ETO22371.1 - 2.7 8.0 14.6 2 8.4 11.0 2.0 2 0 0 2 2 2 0 Telomere-associated protein TERB2 CLN3 PF02487.17 ETO22371.1 - 2.7 7.0 6.8 4.3 6.3 6.8 1.3 1 0 0 1 1 1 0 CLN3 protein Spore_coat_CotO PF14153.6 ETO22371.1 - 2.8 7.8 20.0 3 7.7 17.7 1.9 2 0 0 2 2 2 0 Spore coat protein CotO ALMT PF11744.8 ETO22371.1 - 6.2 5.5 12.7 0.69 8.7 8.6 1.4 2 0 0 2 2 2 0 Aluminium activated malate transporter CobT PF06213.12 ETO22371.1 - 9.2 5.6 22.0 0.34 10.3 15.2 1.8 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT Myb_DNA-binding PF00249.31 ETO22372.1 - 5.6e-20 71.3 5.1 5.6e-12 45.7 1.2 2.5 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO22372.1 - 1.3e-17 63.8 12.7 6.4e-14 52.0 3.5 2.3 1 1 1 2 2 2 2 Myb-like DNA-binding domain SLIDE PF09111.10 ETO22372.1 - 0.0018 18.2 0.2 2.1 8.4 0.0 2.4 1 1 1 2 2 2 2 SLIDE Rap1_C PF11626.8 ETO22372.1 - 0.013 15.5 1.3 0.49 10.5 0.1 2.3 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain MFP2b PF12150.8 ETO22372.1 - 0.037 13.3 0.1 0.043 13.1 0.1 1.0 1 0 0 1 1 1 0 Cytosolic motility protein Met_synt_B12 PF02965.17 ETO22372.1 - 0.038 13.5 0.2 0.049 13.1 0.2 1.2 1 0 0 1 1 1 0 Vitamin B12 dependent methionine synthase, activation domain RRM_1 PF00076.22 ETO22373.1 - 4.6e-18 64.8 0.1 5.7e-11 42.1 0.0 2.1 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO22373.1 - 0.00041 20.3 0.0 0.00081 19.4 0.0 1.5 1 0 0 1 1 1 1 RNA binding domain RRM_3 PF08777.11 ETO22373.1 - 0.00083 19.4 0.2 0.0018 18.3 0.1 1.6 1 1 1 2 2 2 1 RNA binding motif Nup35_RRM_2 PF14605.6 ETO22373.1 - 0.0025 17.8 0.1 0.021 14.8 0.0 2.2 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif SecE PF00584.20 ETO22373.1 - 0.099 12.6 3.2 0.16 12.0 3.2 1.3 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex DUF3882 PF07066.11 ETO22374.1 - 0.047 13.8 0.5 0.063 13.3 0.5 1.2 1 0 0 1 1 1 0 Lactococcus phage M3 protein PRP38_assoc PF12871.7 ETO22375.1 - 1.5e-06 28.8 46.0 2.2e-05 25.0 34.8 2.4 2 0 0 2 2 2 2 Pre-mRNA-splicing factor 38-associated hydrophilic C-term GASA PF02704.14 ETO22375.1 - 0.097 12.8 2.3 0.29 11.3 2.3 1.8 1 0 0 1 1 1 0 Gibberellin regulated protein YhzD PF14120.6 ETO22376.1 - 0.57 10.3 3.9 4.8 7.4 0.3 2.4 2 0 0 2 2 2 0 YhzD-like protein NPR1_interact PF15699.5 ETO22377.1 - 0.012 16.2 0.1 0.044 14.4 0.1 1.9 1 0 0 1 1 1 0 NPR1 interacting CMAS PF02353.20 ETO22377.1 - 0.028 13.7 0.5 0.049 12.9 0.5 1.3 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase DUF3439 PF11921.8 ETO22377.1 - 0.77 9.7 11.3 1.5 8.8 11.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 ETO22378.1 - 6.6e-54 183.0 0.0 1.4e-53 181.9 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22378.1 - 5e-25 88.3 0.0 1e-24 87.2 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Mad3_BUB1_I PF08311.12 ETO22378.1 - 4.5e-11 42.8 5.1 9.5e-11 41.8 5.1 1.6 1 0 0 1 1 1 1 Mad3/BUB1 homology region 1 Mad3_BUB1_I_2 PF17014.5 ETO22378.1 - 0.00027 21.1 0.3 0.00091 19.3 0.2 1.9 2 0 0 2 2 2 1 Putative Mad3/BUB1 like region 1 protein FTA2 PF13095.6 ETO22378.1 - 0.0022 17.7 0.6 1.6 8.3 0.0 2.8 3 0 0 3 3 3 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ETO22378.1 - 0.0022 17.9 0.0 0.059 13.3 0.0 2.3 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO22378.1 - 0.0038 16.9 0.0 0.012 15.3 0.0 1.8 1 0 0 1 1 1 1 RIO1 family BUD22 PF09073.10 ETO22378.1 - 0.7 9.2 30.9 1.2 8.4 30.9 1.4 1 0 0 1 1 1 0 BUD22 Mucin PF01456.17 ETO22378.1 - 3.9 7.4 17.2 7.2 6.6 17.2 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Ku_C PF03730.14 ETO22379.1 - 2.7 8.7 8.4 0.88 10.3 4.1 2.2 1 1 1 2 2 2 0 Ku70/Ku80 C-terminal arm Pkinase PF00069.25 ETO22380.1 - 1.4e-19 70.5 0.0 1.4e-19 70.5 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22380.1 - 6.2e-11 42.1 0.0 7.8e-11 41.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Choline_kinase PF01633.20 ETO22380.1 - 0.00027 20.6 0.2 0.0011 18.5 0.0 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kinase-like PF14531.6 ETO22380.1 - 0.0026 17.2 0.0 0.0036 16.7 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO22380.1 - 0.019 14.3 0.0 0.028 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Chorion_2 PF03964.15 ETO22381.1 - 0.00089 20.1 2.8 0.0016 19.2 2.8 1.4 1 0 0 1 1 1 1 Chorion family 2 CCDC24 PF15669.5 ETO22381.1 - 0.28 11.0 4.3 0.51 10.2 4.3 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family SSP160 PF06933.11 ETO22381.1 - 1.9 6.6 12.9 2.3 6.3 12.9 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SR-25 PF10500.9 ETO22381.1 - 2.7 7.5 25.2 0.82 9.2 17.9 2.1 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DUF4547 PF15080.6 ETO22382.1 - 0.00036 20.2 0.1 0.0015 18.2 0.0 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4547) Bcl-2_BAD PF10514.9 ETO22382.1 - 0.82 10.1 7.2 0.098 13.1 2.3 1.9 2 0 0 2 2 2 0 Pro-apoptotic Bcl-2 protein, BAD DUF3391 PF11871.8 ETO22382.1 - 5 7.7 11.5 9.7 6.7 3.9 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3391) CDC45 PF02724.14 ETO22382.1 - 8.8 4.5 36.8 1.5 7.0 11.9 2.1 2 0 0 2 2 2 0 CDC45-like protein Peptidase_C65 PF10275.9 ETO22383.1 - 0.00049 19.6 0.4 0.0014 18.2 0.4 1.8 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 ETO22383.1 - 0.0029 18.1 0.2 0.014 15.8 0.0 2.2 2 0 0 2 2 2 1 OTU-like cysteine protease CDC45 PF02724.14 ETO22383.1 - 0.0075 14.6 8.4 0.0095 14.3 8.4 1.2 1 0 0 1 1 1 1 CDC45-like protein TFIIF_alpha PF05793.12 ETO22383.1 - 0.009 14.7 12.9 0.013 14.2 12.9 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3417 PF11897.8 ETO22383.1 - 0.011 16.1 0.0 0.39 11.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3417) Nop14 PF04147.12 ETO22383.1 - 0.034 12.4 11.2 0.046 12.0 11.2 1.1 1 0 0 1 1 1 0 Nop14-like family Merozoite_SPAM PF07133.11 ETO22383.1 - 0.036 14.1 22.9 0.074 13.0 22.9 1.5 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Pox_Ag35 PF03286.14 ETO22383.1 - 2.4 7.9 11.5 4.6 7.0 11.5 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.17 ETO22383.1 - 5.5 5.6 9.3 8 5.1 9.3 1.2 1 0 0 1 1 1 0 Presenilin THAP PF05485.12 ETO22384.1 - 0.095 13.6 0.2 5.5 8.0 0.0 2.3 2 0 0 2 2 2 0 THAP domain Limkain-b1 PF11608.8 ETO22384.1 - 0.13 12.3 0.0 0.3 11.2 0.0 1.6 1 0 0 1 1 1 0 Limkain b1 Baculo_11_kDa PF06143.11 ETO22387.1 - 0.072 12.7 0.1 0.072 12.7 0.1 4.6 5 0 0 5 5 5 0 Baculovirus 11 kDa family SARAF PF06682.12 ETO22387.1 - 0.085 12.5 0.2 0.21 11.2 0.2 1.6 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis FAM176 PF14851.6 ETO22387.1 - 0.1 12.3 0.2 0.1 12.3 0.2 1.7 2 0 0 2 2 2 0 FAM176 family KCT2 PF17818.1 ETO22387.1 - 0.33 11.0 0.8 0.83 9.8 0.8 1.7 1 0 0 1 1 1 0 Keratinocyte-associated gene product CrgA PF06781.12 ETO22387.1 - 1.6 8.8 0.0 1.6 8.8 0.0 3.3 3 1 0 3 3 3 0 Cell division protein CrgA Trp_halogenase PF04820.14 ETO22388.1 - 0.16 10.8 0.0 0.22 10.3 0.0 1.1 1 0 0 1 1 1 0 Tryptophan halogenase RNase_PH PF01138.21 ETO22389.1 - 6.2e-24 85.0 0.0 1.2e-23 84.0 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 RNase_PH_C PF03725.15 ETO22389.1 - 0.015 15.3 0.1 0.044 13.8 0.1 1.7 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 CBS PF00571.28 ETO22390.1 - 6e-12 45.8 0.0 5.8e-05 23.5 0.0 3.2 3 0 0 3 3 3 2 CBS domain LAMTOR5 PF16672.5 ETO22390.1 - 0.13 12.3 0.2 3 7.8 0.0 2.7 2 1 1 3 3 3 0 Ragulator complex protein LAMTOR5 PspB PF06667.12 ETO22391.1 - 0.13 12.4 0.2 0.27 11.3 0.2 1.5 1 0 0 1 1 1 0 Phage shock protein B DUF2981 PF11200.8 ETO22391.1 - 1.1 9.0 6.3 1.4 8.6 6.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) SUIM_assoc PF16619.5 ETO22392.1 - 0.13 12.3 7.1 1.8 8.7 7.1 2.8 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 PI3_PI4_kinase PF00454.27 ETO22393.1 - 0.0045 16.8 1.0 0.013 15.3 0.0 2.0 1 1 1 2 2 2 1 Phosphatidylinositol 3- and 4-kinase zf-C2H2_assoc2 PF16624.5 ETO22394.1 - 1.5 9.9 13.4 14 6.8 6.9 3.4 2 1 0 2 2 2 0 Unstructured region upstream of a zinc-finger XPA_C PF05181.12 ETO22395.1 - 2.2e-09 37.1 3.2 1.7e-06 27.8 1.5 2.5 2 0 0 2 2 2 2 XPA protein C-terminus TBCC PF07986.12 ETO22395.1 - 0.057 13.2 0.2 0.057 13.2 0.2 1.7 2 0 0 2 2 2 0 Tubulin binding cofactor C BCL_N PF04714.13 ETO22395.1 - 0.13 12.4 1.1 0.35 11.0 1.1 1.7 1 0 0 1 1 1 0 BCL7, N-terminal conserver region zinc_ribbon_13 PF09855.9 ETO22395.1 - 0.48 10.6 4.7 4.4 7.5 0.2 2.6 2 0 0 2 2 2 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) zf-CCCH PF00642.24 ETO22396.1 - 2.9e-07 30.2 4.4 4.5e-07 29.6 4.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) HEPN_Cthe2314 PF18730.1 ETO22396.1 - 0.0073 16.4 0.1 0.014 15.5 0.1 1.4 1 0 0 1 1 1 1 Cthe_2314-like HEPN zf_CCCH_4 PF18345.1 ETO22396.1 - 0.0076 16.3 6.5 0.015 15.3 6.5 1.5 1 0 0 1 1 1 1 Zinc finger domain Osmo_CC PF08946.10 ETO22396.1 - 0.022 15.0 1.2 0.043 14.1 1.2 1.4 1 0 0 1 1 1 0 Osmosensory transporter coiled coil ABC_tran_CTD PF16326.5 ETO22396.1 - 0.025 14.8 0.3 0.052 13.8 0.3 1.4 1 0 0 1 1 1 0 ABC transporter C-terminal domain PI3K_P85_iSH2 PF16454.5 ETO22396.1 - 0.19 11.3 3.9 0.54 9.8 0.5 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Csm1_N PF18504.1 ETO22396.1 - 0.44 10.9 3.7 1.6 9.2 3.7 1.9 1 0 0 1 1 1 0 Csm1 N-terminal domain RPN2_C PF18004.1 ETO22397.1 - 2.9e-41 141.1 13.3 3.3e-41 140.9 13.3 1.0 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain FANCF PF11107.8 ETO22397.1 - 0.022 14.0 1.4 0.027 13.7 1.4 1.1 1 0 0 1 1 1 0 Fanconi anemia group F protein (FANCF) PAT1 PF09770.9 ETO22397.1 - 0.025 12.9 7.5 0.029 12.7 7.5 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 EMC3_TMCO1 PF01956.16 ETO22397.1 - 2.1 8.0 5.1 4.1 7.1 5.1 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Presenilin PF01080.17 ETO22397.1 - 4.6 5.9 5.5 4.8 5.8 5.5 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 ETO22397.1 - 5.2 6.5 9.0 7.9 5.9 9.0 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Vfa1 PF08432.10 ETO22397.1 - 7.2 6.9 14.7 9.7 6.5 14.7 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Agenet PF05641.12 ETO22399.1 - 1.3e-06 28.8 0.1 2e-06 28.2 0.1 1.3 1 0 0 1 1 1 1 Agenet domain zf-C3HC4_3 PF13920.6 ETO22400.1 - 1.2e-08 34.7 10.3 1.9e-08 34.0 10.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO22400.1 - 2.5e-05 24.1 9.1 4.5e-05 23.2 9.1 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 SAM_2 PF07647.17 ETO22400.1 - 4.2e-05 23.6 0.2 8.6e-05 22.6 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO22400.1 - 0.00019 21.8 0.0 0.00048 20.5 0.1 1.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) zf-RING_2 PF13639.6 ETO22400.1 - 0.21 11.9 12.2 0.51 10.7 12.2 1.7 1 0 0 1 1 1 0 Ring finger domain DUF483 PF04467.12 ETO22400.1 - 0.58 10.2 4.9 1.7 8.7 4.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF483) zf-RING_5 PF14634.6 ETO22400.1 - 6.9 6.7 12.3 14 5.8 12.3 1.5 1 0 0 1 1 1 0 zinc-RING finger domain tRNA-synt_1b PF00579.25 ETO22401.1 - 1.8e-57 194.9 0.0 2.2e-57 194.6 0.0 1.1 1 0 0 1 1 1 1 tRNA synthetases class I (W and Y) Get5_C PF18514.1 ETO22401.1 - 0.9 9.3 3.5 32 4.4 0.1 3.2 3 0 0 3 3 3 0 Get5 C-terminal domain RrnaAD PF00398.20 ETO22403.1 - 9.9e-56 188.7 0.0 8.6e-55 185.7 0.0 2.0 1 1 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltransf_25 PF13649.6 ETO22403.1 - 1.8e-05 25.4 0.0 3.5e-05 24.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO22403.1 - 0.002 18.9 0.0 0.0052 17.5 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO22403.1 - 0.0025 17.6 0.0 0.013 15.4 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO22403.1 - 0.0048 17.5 0.0 0.014 16.0 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain DREV PF05219.12 ETO22403.1 - 0.019 14.1 0.0 0.031 13.4 0.0 1.3 1 0 0 1 1 1 0 DREV methyltransferase Methyltransf_4 PF02390.17 ETO22403.1 - 0.02 14.4 0.0 0.037 13.5 0.0 1.5 1 0 0 1 1 1 0 Putative methyltransferase DUF1242 PF06842.12 ETO22403.1 - 0.021 14.6 1.3 0.048 13.5 1.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1242) Methyltransf_31 PF13847.6 ETO22403.1 - 0.034 13.9 0.0 0.073 12.9 0.0 1.6 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 ETO22403.1 - 0.038 13.7 0.0 0.061 13.1 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) DOT1 PF08123.13 ETO22403.1 - 0.038 13.5 0.0 0.064 12.8 0.0 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 NodS PF05401.11 ETO22403.1 - 0.057 13.0 0.0 0.097 12.3 0.0 1.3 1 0 0 1 1 1 0 Nodulation protein S (NodS) Agenet PF05641.12 ETO22404.1 - 0.045 14.2 0.0 0.17 12.4 0.0 2.0 1 0 0 1 1 1 0 Agenet domain RR_TM4-6 PF06459.12 ETO22404.1 - 1.1 9.1 8.7 1.6 8.5 8.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 WD40 PF00400.32 ETO22405.1 - 0.0085 16.9 2.3 0.29 12.1 0.1 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Sas6_CC PF18594.1 ETO22405.1 - 0.18 11.7 0.3 0.18 11.7 0.3 1.9 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain DUF4570 PF15134.6 ETO22407.1 - 2 8.4 11.5 0.21 11.6 6.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4570) WD40 PF00400.32 ETO22410.1 - 4.7e-28 96.9 5.9 2.5e-07 31.3 0.2 5.9 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22410.1 - 1.2e-08 35.1 0.7 0.019 15.3 0.0 4.1 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO22410.1 - 5e-08 32.1 1.8 0.34 9.5 0.0 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 NPR1_interact PF15699.5 ETO22414.1 - 0.56 10.9 13.8 0.12 13.0 10.3 1.6 2 0 0 2 2 2 0 NPR1 interacting BEX PF04538.12 ETO22414.1 - 4.8 7.8 18.5 0.27 11.8 9.8 2.1 2 0 0 2 2 2 0 Brain expressed X-linked like family bZIP_1 PF00170.21 ETO22416.1 - 0.0077 16.3 7.5 0.0077 16.3 7.5 3.5 3 0 0 3 3 3 1 bZIP transcription factor DEP PF00610.21 ETO22417.1 - 1.4e-21 76.3 0.3 1.2e-10 41.3 0.1 3.1 3 0 0 3 3 3 2 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_7 PF13499.6 ETO22417.1 - 2.2e-08 34.4 4.5 0.00035 21.0 0.9 2.9 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO22417.1 - 6.1e-08 32.0 9.1 0.18 11.8 0.2 5.0 5 0 0 5 5 5 3 EF-hand domain EF-hand_1 PF00036.32 ETO22417.1 - 1.9e-07 30.2 5.4 0.085 12.4 0.0 4.4 5 0 0 5 5 5 2 EF hand EF-hand_8 PF13833.6 ETO22417.1 - 0.0017 18.1 1.8 0.0066 16.3 0.2 2.7 2 1 0 2 2 2 1 EF-hand domain pair DUF4271 PF14093.6 ETO22417.1 - 0.59 10.0 17.5 1.3 8.8 16.8 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) DUF3784 PF12650.7 ETO22417.1 - 1 9.6 11.1 1.5 9.0 2.6 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) EI24 PF07264.11 ETO22417.1 - 3.9 7.7 10.0 7.9 6.7 10.0 1.5 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF3953 PF13129.6 ETO22417.1 - 7.2 6.5 6.5 22 4.9 0.0 3.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3953) NOA36 PF06524.12 ETO22418.1 - 2.5 7.4 29.0 0.013 14.8 19.5 2.0 2 0 0 2 2 2 0 NOA36 protein MCU PF04678.13 ETO22418.1 - 5.4 7.1 6.4 2.5 8.2 0.1 2.7 2 1 0 2 2 2 0 Mitochondrial calcium uniporter Dynein_heavy PF03028.15 ETO22419.1 - 6.8e-17 61.7 0.1 1.3e-16 60.7 0.1 1.5 1 0 0 1 1 1 1 Dynein heavy chain region D6 P-loop domain CEBP1_N PF16368.5 ETO22419.1 - 0.048 13.2 0.0 0.068 12.7 0.0 1.1 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein 1 N-terminus Myotub-related PF06602.14 ETO22420.1 - 3.7e-36 124.8 0.1 4.7e-36 124.5 0.1 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DUF4604 PF15377.6 ETO22421.1 - 0.0011 19.5 11.8 0.0011 19.4 11.8 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4604) RNA_polI_A34 PF08208.11 ETO22421.1 - 0.0025 18.0 8.9 0.0025 17.9 8.9 1.1 1 0 0 1 1 1 1 DNA-directed RNA polymerase I subunit RPA34.5 YL1 PF05764.13 ETO22421.1 - 0.042 14.0 15.0 0.045 13.9 15.0 1.1 1 0 0 1 1 1 0 YL1 nuclear protein ERK-JNK_inhib PF15002.6 ETO22421.1 - 0.14 11.8 9.5 0.13 11.9 9.5 1.1 1 0 0 1 1 1 0 ERK and JNK pathways, inhibitor BCIP PF13862.6 ETO22421.1 - 0.17 11.7 8.2 0.18 11.6 8.2 1.1 1 0 0 1 1 1 0 p21-C-terminal region-binding protein HA2 PF04408.23 ETO22421.1 - 0.28 11.5 1.5 0.26 11.6 1.5 1.1 1 0 0 1 1 1 0 Helicase associated domain (HA2) Sld3_N PF18523.1 ETO22421.1 - 0.29 11.3 6.5 0.35 11.0 6.5 1.1 1 0 0 1 1 1 0 Sld3 N-terminal domain Med19 PF10278.9 ETO22421.1 - 0.38 10.7 15.8 0.34 10.8 15.8 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Cnd1_N PF12922.7 ETO22421.1 - 0.68 9.8 5.8 0.75 9.6 5.8 1.1 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term SR-25 PF10500.9 ETO22421.1 - 0.76 9.3 17.9 0.91 9.1 17.9 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 ETO22421.1 - 1.1 7.5 10.4 1.1 7.5 10.4 1.0 1 0 0 1 1 1 0 CDC45-like protein SPT6_acidic PF14632.6 ETO22421.1 - 1.1 9.9 24.6 2.7 8.6 24.7 1.5 1 1 1 2 2 2 0 Acidic N-terminal SPT6 AP-5_subunit_s1 PF15001.6 ETO22421.1 - 1.2 9.1 5.3 1.3 8.9 5.3 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 ETRAMP PF09716.10 ETO22421.1 - 1.3 9.1 8.4 1.4 9.0 8.4 1.2 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Ferlin_C PF16165.5 ETO22421.1 - 2.6 8.0 13.7 3.1 7.7 13.7 1.1 1 0 0 1 1 1 0 Ferlin C-terminus Sporozoite_P67 PF05642.11 ETO22421.1 - 7.4 4.5 8.7 8.2 4.4 8.7 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 ETO22422.1 - 2.7e-17 63.0 2.7 5.7e-08 32.4 0.5 3.3 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22422.1 - 3e-05 23.5 6.0 0.002 17.5 5.8 2.7 2 1 0 2 2 2 1 Protein tyrosine kinase Atrophin-1 PF03154.15 ETO22422.1 - 0.0032 15.9 1.0 0.0032 15.9 1.0 2.0 2 0 0 2 2 2 1 Atrophin-1 family Adaptin_binding PF10199.9 ETO22422.1 - 0.15 12.6 10.1 0.35 11.5 10.1 1.5 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Pkinase_fungal PF17667.1 ETO22422.1 - 0.18 10.5 7.9 0.034 12.9 0.3 2.1 2 0 0 2 2 2 0 Fungal protein kinase Ureide_permease PF07168.11 ETO22422.1 - 0.31 9.7 2.2 0.55 8.9 2.2 1.4 1 0 0 1 1 1 0 Ureide permease DUF4820 PF16091.5 ETO22422.1 - 1.2 8.4 6.1 3 7.1 6.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.17 ETO22422.1 - 1.6 7.4 4.5 3.2 6.4 4.5 1.4 1 0 0 1 1 1 0 Presenilin Phage_Gp23 PF10669.9 ETO22422.1 - 1.9 8.9 12.1 5.3 7.4 12.1 1.7 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Afi1 PF07792.12 ETO22422.1 - 4.7 7.7 12.6 7.1 7.1 7.2 2.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DDHD PF02862.17 ETO22422.1 - 6.1 6.9 9.4 0.41 10.8 2.5 2.1 2 0 0 2 2 2 0 DDHD domain Tsg PF04668.12 ETO22422.1 - 8.3 7.1 9.6 34 5.1 3.7 2.7 2 0 0 2 2 2 0 Twisted gastrulation (Tsg) protein conserved region AAA_6 PF12774.7 ETO22423.1 - 8e-160 531.2 0.5 1.9e-156 520.1 0.0 4.2 4 0 0 4 4 4 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 ETO22423.1 - 3.4e-117 391.9 17.2 3.4e-117 391.9 17.2 3.8 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 ETO22423.1 - 5.6e-103 343.8 2.1 3.3e-102 341.3 0.0 3.5 4 0 0 4 4 3 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 ETO22423.1 - 4.9e-88 293.9 4.0 4.9e-88 293.9 4.0 3.5 4 0 0 4 4 2 1 ATP-binding dynein motor region AAA_7 PF12775.7 ETO22423.1 - 3.1e-66 222.3 0.7 2.3e-60 203.2 0.1 4.0 3 0 0 3 3 3 2 P-loop containing dynein motor region MT PF12777.7 ETO22423.1 - 7e-47 160.1 19.5 1.6e-46 159.0 19.5 1.5 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 ETO22423.1 - 4.2e-27 94.8 0.5 1.2e-25 90.1 0.1 3.3 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 ETO22423.1 - 1.1e-19 70.5 0.1 7.5e-19 67.8 0.1 2.6 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ETO22423.1 - 1.2e-16 61.0 0.4 0.0016 18.5 0.0 6.3 6 1 0 6 6 5 3 AAA domain (dynein-related subfamily) Dynein_heavy PF03028.15 ETO22423.1 - 3.7e-12 46.4 0.4 2.2e-07 31.0 0.0 4.4 4 0 0 4 4 4 2 Dynein heavy chain region D6 P-loop domain AAA PF00004.29 ETO22423.1 - 7.3e-12 45.9 0.1 0.0011 19.3 0.0 4.6 4 0 0 4 4 4 2 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO22423.1 - 1e-06 29.2 1.6 0.092 13.1 0.0 5.2 5 0 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 ETO22423.1 - 7.6e-05 23.0 5.5 0.44 10.8 0.0 5.3 6 0 0 6 6 3 1 AAA domain RNA_helicase PF00910.22 ETO22423.1 - 9.5e-05 22.7 0.0 1.1 9.7 0.0 4.0 3 0 0 3 3 3 1 RNA helicase TsaE PF02367.17 ETO22423.1 - 0.00028 20.9 0.2 5.7 7.0 0.0 3.8 3 0 0 3 3 3 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ETO22423.1 - 0.00035 20.3 0.1 0.29 10.8 0.0 3.3 3 0 0 3 3 3 1 Sigma-54 interaction domain AAA_18 PF13238.6 ETO22423.1 - 0.00048 20.7 4.4 1.6 9.2 0.0 6.3 6 0 0 6 6 5 1 AAA domain ABC_tran PF00005.27 ETO22423.1 - 0.00073 20.1 5.2 5.5 7.5 0.0 5.5 6 1 0 6 6 3 1 ABC transporter AAA_33 PF13671.6 ETO22423.1 - 0.00095 19.3 0.0 4.6 7.4 0.0 4.4 3 0 0 3 3 3 1 AAA domain AAA_14 PF13173.6 ETO22423.1 - 0.0022 18.0 5.3 0.094 12.8 0.0 4.3 5 0 0 5 5 3 1 AAA domain NACHT PF05729.12 ETO22423.1 - 0.0048 16.8 0.0 0.7 9.8 0.0 3.5 3 0 0 3 3 3 1 NACHT domain NB-ARC PF00931.22 ETO22423.1 - 0.0052 16.0 0.1 0.0052 16.0 0.1 3.4 4 0 0 4 4 3 1 NB-ARC domain AAA_30 PF13604.6 ETO22423.1 - 0.008 15.9 0.1 6.5 6.4 0.0 3.6 3 0 0 3 3 3 0 AAA domain NTPase_1 PF03266.15 ETO22423.1 - 0.049 13.5 0.2 2 8.3 0.1 3.5 3 0 0 3 3 3 0 NTPase AAA_28 PF13521.6 ETO22423.1 - 0.11 12.7 0.3 12 6.1 0.0 4.1 4 0 0 4 4 4 0 AAA domain AAA_29 PF13555.6 ETO22423.1 - 0.11 12.2 0.1 3.6 7.4 0.0 3.0 3 0 0 3 3 3 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO22423.1 - 0.2 11.5 1.8 2.7 7.9 0.0 3.7 3 0 0 3 3 2 0 RsgA GTPase Roc PF08477.13 ETO22423.1 - 3.2 8.0 7.6 1 9.6 0.1 3.8 5 0 0 5 5 3 0 Ras of Complex, Roc, domain of DAPkinase Dynein_C PF18199.1 ETO22424.1 - 1.1e-74 251.4 0.3 1.5e-74 251.0 0.3 1.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETO22424.1 - 2.7e-28 98.8 0.1 6.4e-28 97.6 0.1 1.7 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Pkinase PF00069.25 ETO22425.1 - 1e-06 28.4 0.0 2e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22425.1 - 1.9e-05 24.1 0.0 3.2e-05 23.3 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase CCDC117 PF15810.5 ETO22425.1 - 0.051 13.9 2.6 0.084 13.2 2.6 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 117 Presenilin PF01080.17 ETO22425.1 - 0.12 11.2 5.9 0.13 11.0 5.9 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO22425.1 - 0.42 9.8 2.6 0.48 9.6 2.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO22425.1 - 4.8 5.8 18.7 6.6 5.4 18.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CD99L2 PF12301.8 ETO22426.1 - 0.036 14.3 8.4 0.031 14.6 6.9 1.6 1 1 0 1 1 1 0 CD99 antigen like protein 2 Neur_chan_memb PF02932.16 ETO22426.1 - 0.49 10.4 4.2 0.53 10.3 4.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 ETO22426.1 - 2.6 6.8 8.4 3 6.6 8.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO22426.1 - 7.2 5.3 13.3 9.6 4.9 13.3 1.2 1 0 0 1 1 1 0 Presenilin bZIP_1 PF00170.21 ETO22428.1 - 0.0018 18.3 1.4 0.0018 18.3 1.4 2.0 3 0 0 3 3 2 1 bZIP transcription factor CASP_C PF08172.12 ETO22428.1 - 0.0018 17.6 4.8 0.0023 17.3 4.8 1.1 1 0 0 1 1 1 1 CASP C terminal ING PF12998.7 ETO22428.1 - 0.0037 17.8 0.9 0.0037 17.8 0.9 1.6 1 1 1 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding Ead_Ea22 PF13935.6 ETO22428.1 - 0.0039 17.9 1.3 0.0045 17.7 1.3 1.2 1 0 0 1 1 1 1 Ead/Ea22-like protein DivIC PF04977.15 ETO22428.1 - 0.0042 16.8 2.9 0.0042 16.8 2.9 2.2 1 1 1 2 2 2 1 Septum formation initiator Fez1 PF06818.15 ETO22428.1 - 0.0065 17.0 9.6 0.0066 16.9 9.6 1.0 1 0 0 1 1 1 1 Fez1 SOGA PF11365.8 ETO22428.1 - 0.0067 17.5 4.6 0.0067 17.5 4.6 1.5 1 1 0 1 1 1 1 Protein SOGA Spc29 PF17082.5 ETO22428.1 - 0.0068 16.3 2.8 0.0073 16.2 2.8 1.1 1 0 0 1 1 1 1 Spindle Pole Component 29 DUF2570 PF10828.8 ETO22428.1 - 0.0071 16.1 3.4 0.012 15.4 3.4 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2570) TSC22 PF01166.18 ETO22428.1 - 0.012 16.0 2.9 0.016 15.5 2.3 1.6 1 1 0 1 1 1 0 TSC-22/dip/bun family DASH_Spc19 PF08287.11 ETO22428.1 - 0.023 14.6 9.5 0.026 14.4 9.5 1.1 1 0 0 1 1 1 0 Spc19 Fib_alpha PF08702.10 ETO22428.1 - 0.024 14.8 3.7 0.023 14.9 2.8 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Fmp27_WPPW PF10359.9 ETO22428.1 - 0.025 13.4 10.6 0.029 13.2 10.6 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain YabA PF06156.13 ETO22428.1 - 0.043 14.4 4.6 0.054 14.1 4.6 1.2 1 0 0 1 1 1 0 Initiation control protein YabA Spc7 PF08317.11 ETO22428.1 - 0.054 12.4 8.6 0.069 12.0 8.6 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein SlyX PF04102.12 ETO22428.1 - 0.059 14.0 1.0 0.098 13.3 1.0 1.5 1 0 0 1 1 1 0 SlyX RasGAP_C PF03836.15 ETO22428.1 - 0.071 13.3 6.6 0.11 12.7 6.5 1.3 1 1 0 1 1 1 0 RasGAP C-terminus MPS2 PF17060.5 ETO22428.1 - 0.083 12.1 8.7 0.12 11.6 8.2 1.6 1 1 0 1 1 1 0 Monopolar spindle protein 2 DUF641 PF04859.12 ETO22428.1 - 0.12 12.8 9.7 0.089 13.1 6.3 2.0 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF724 PF05266.14 ETO22428.1 - 0.15 11.8 12.8 0.35 10.7 12.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Atg14 PF10186.9 ETO22428.1 - 0.17 10.9 9.2 0.2 10.7 9.2 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 TMCO5 PF14992.6 ETO22428.1 - 0.18 11.4 9.9 0.2 11.2 9.9 1.0 1 0 0 1 1 1 0 TMCO5 family TMF_DNA_bd PF12329.8 ETO22428.1 - 0.19 11.8 19.2 0.24 11.4 12.1 2.4 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding RBD-FIP PF09457.10 ETO22428.1 - 0.23 11.4 2.6 1.2 9.1 0.4 2.3 1 1 1 2 2 2 0 FIP domain ZapB PF06005.12 ETO22428.1 - 0.27 11.7 8.6 0.13 12.7 6.3 1.8 1 1 1 2 2 2 0 Cell division protein ZapB DUF1043 PF06295.12 ETO22428.1 - 0.63 10.0 6.3 1.3 9.0 6.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1043) bZIP_2 PF07716.15 ETO22428.1 - 0.79 9.9 8.1 0.14 12.2 4.5 1.7 2 0 0 2 2 1 0 Basic region leucine zipper BST2 PF16716.5 ETO22428.1 - 0.81 10.3 9.1 0.09 13.4 4.4 1.7 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 WRNPLPNID PF15017.6 ETO22428.1 - 0.88 10.5 6.3 0.19 12.6 2.3 1.9 1 1 1 2 2 2 0 Putative WW-binding domain and destruction box Med9 PF07544.13 ETO22428.1 - 2.3 8.4 9.2 0.45 10.6 3.8 2.3 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 UPF0242 PF06785.11 ETO22428.1 - 2.7 8.0 11.3 3.1 7.9 11.3 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus FlaC_arch PF05377.11 ETO22428.1 - 3.8 8.0 10.8 0.58 10.6 2.7 2.6 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) TMPIT PF07851.13 ETO22428.1 - 5.2 6.2 6.8 5.9 6.0 6.8 1.1 1 0 0 1 1 1 0 TMPIT-like protein V_ATPase_I PF01496.19 ETO22428.1 - 5.9 4.7 7.7 6.2 4.6 7.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family LMBR1 PF04791.16 ETO22428.1 - 6.9 5.4 5.1 7.6 5.3 5.1 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein TMF_DNA_bd PF12329.8 ETO22429.1 - 0.021 14.8 5.2 0.021 14.8 5.2 4.7 4 1 0 4 4 4 0 TATA element modulatory factor 1 DNA binding Sas6_CC PF18594.1 ETO22429.1 - 1.2 9.0 6.1 5 7.0 6.1 2.2 1 0 0 1 1 1 0 Sas6/XLF/XRCC4 coiled-coil domain Ribosomal_S17 PF00366.20 ETO22431.1 - 0.2 11.8 2.3 0.57 10.3 2.3 1.7 1 0 0 1 1 1 0 Ribosomal protein S17 SAP PF02037.27 ETO22432.1 - 0.0049 16.6 0.2 0.0049 16.6 0.2 2.2 3 0 0 3 3 3 1 SAP domain NYD-SP28 PF14772.6 ETO22432.1 - 0.096 12.7 0.8 0.096 12.7 0.8 2.3 2 1 1 3 3 3 0 Sperm tail fn3_2 PF16893.5 ETO22432.1 - 0.13 12.5 0.3 0.23 11.6 0.3 1.5 1 0 0 1 1 1 0 Fibronectin type III domain WD40 PF00400.32 ETO22434.1 - 2.7e-19 69.1 9.9 3.1e-05 24.6 0.4 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO22434.1 - 8.9e-06 24.6 1.8 0.053 12.2 0.1 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO22434.1 - 0.0016 18.3 0.6 0.028 14.2 0.6 2.3 1 1 0 1 1 1 1 ATP-dependent RecD-like DNA helicase SH3 domain ANAPC4_WD40 PF12894.7 ETO22434.1 - 0.016 15.5 0.1 1.1 9.6 0.0 2.7 2 1 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain DUF678 PF05077.12 ETO22434.1 - 0.022 14.9 1.8 4.6 7.5 0.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF678) IGR PF09597.10 ETO22436.1 - 0.095 12.8 0.0 0.36 11.0 0.1 2.0 2 0 0 2 2 2 0 IGR protein motif RhoGAP PF00620.27 ETO22437.1 - 1.1e-09 38.3 0.0 1.8e-09 37.6 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain DUF2267 PF10025.9 ETO22437.1 - 0.07 13.4 0.0 0.13 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2267) ELO PF01151.18 ETO22438.1 - 1.6e-27 96.6 5.7 1.6e-27 96.6 5.0 1.3 1 1 0 1 1 1 1 GNS1/SUR4 family WD40 PF00400.32 ETO22440.1 - 4.7e-08 33.6 6.7 0.00043 21.0 0.2 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22440.1 - 0.043 14.1 0.0 14 6.1 0.0 3.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF2757 PF10955.8 ETO22440.1 - 0.085 13.1 0.0 1 9.7 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2757) DUF155 PF02582.14 ETO22440.1 - 0.13 12.4 0.0 0.26 11.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 Actin PF00022.19 ETO22441.1 - 1e-70 238.5 0.0 1.1e-69 235.0 0.0 1.9 1 1 0 1 1 1 1 Actin dCMP_cyt_deam_2 PF08211.12 ETO22441.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.3 1 0 0 1 1 1 0 Cytidine and deoxycytidylate deaminase zinc-binding region DUF4746 PF15928.5 ETO22443.1 - 0.0077 15.7 8.4 0.0087 15.5 8.4 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4746) F-box-like PF12937.7 ETO22443.1 - 0.034 14.0 0.0 0.062 13.2 0.0 1.4 1 0 0 1 1 1 0 F-box-like CDC45 PF02724.14 ETO22443.1 - 1.5 7.0 10.1 1.8 6.8 10.1 1.1 1 0 0 1 1 1 0 CDC45-like protein HEAT_UF PF18817.1 ETO22443.1 - 9.6 6.6 7.1 2.6 8.4 3.7 1.9 2 0 0 2 2 2 0 Repeat of uncharacterized protein PH0542 RGS PF00615.19 ETO22444.1 - 1.2e-09 38.5 0.6 1.9e-09 37.8 0.6 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4355 PF14265.6 ETO22445.1 - 0.035 14.4 2.9 0.13 12.5 0.8 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4355) DUF434 PF04256.12 ETO22445.1 - 0.13 12.0 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF434) RR_TM4-6 PF06459.12 ETO22445.1 - 5.4 6.8 10.0 3.6 7.3 2.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 MFS_1 PF07690.16 ETO22446.1 - 1.7e-11 43.7 9.6 1.3e-10 40.7 9.6 1.9 1 1 0 1 1 1 1 Major Facilitator Superfamily BT1 PF03092.16 ETO22446.1 - 0.013 13.7 0.4 0.026 12.8 0.2 1.5 1 1 0 1 1 1 0 BT1 family Sugar_tr PF00083.24 ETO22446.1 - 0.14 11.0 6.8 0.03 13.2 2.9 1.9 2 1 0 2 2 2 0 Sugar (and other) transporter His_Phos_1 PF00300.22 ETO22447.1 - 3.4e-09 36.7 0.0 0.00017 21.3 0.0 2.3 2 0 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) DUF3246 PF11596.8 ETO22448.1 - 1.4 8.3 8.4 5 6.5 4.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3246) MRI PF15325.6 ETO22448.1 - 1.9 9.6 7.8 1.7 9.8 4.0 2.5 2 1 0 2 2 2 0 Modulator of retrovirus infection DUF2817 PF10994.8 ETO22449.1 - 2.3e-48 165.4 17.5 3.5e-23 82.6 5.4 4.4 2 1 1 3 3 3 3 Protein of unknown function (DUF2817) AstE_AspA PF04952.14 ETO22449.1 - 0.0062 15.6 0.4 0.011 14.8 0.4 1.3 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family SR-25 PF10500.9 ETO22449.1 - 0.019 14.6 36.5 0.43 10.2 3.0 3.3 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein DUF3446 PF11928.8 ETO22449.1 - 0.092 13.1 17.9 0.32 11.3 8.4 2.8 2 0 0 2 2 2 0 Early growth response N-terminal domain SRC-1 PF08832.10 ETO22449.1 - 0.15 13.2 15.1 1 10.4 1.5 3.7 4 0 0 4 4 4 0 Steroid receptor coactivator Peptidase_S49_N PF08496.10 ETO22449.1 - 1 9.4 5.2 0.63 10.1 2.2 2.2 3 0 0 3 3 3 0 Peptidase family S49 N-terminal Herpes_pp85 PF04637.12 ETO22449.1 - 1.2 7.5 6.0 2.4 6.5 1.9 2.2 2 0 0 2 2 2 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Pheromone PF08015.11 ETO22449.1 - 3.2 8.9 10.6 16 6.6 1.7 2.9 2 0 0 2 2 2 0 Fungal mating-type pheromone Chorion_2 PF03964.15 ETO22449.1 - 3.2 8.6 9.9 15 6.5 0.3 2.8 2 0 0 2 2 2 0 Chorion family 2 Presenilin PF01080.17 ETO22449.1 - 5.2 5.7 7.9 0.8 8.4 3.4 1.8 2 0 0 2 2 2 0 Presenilin Orf78 PF06024.12 ETO22450.1 - 0.019 15.3 1.8 3 8.2 0.8 2.7 2 1 0 2 2 2 0 Orf78 (ac78) Radial_spoke_3 PF06098.11 ETO22450.1 - 0.029 13.6 4.1 0.046 13.0 4.1 1.2 1 0 0 1 1 1 0 Radial spoke protein 3 E7 PF00527.18 ETO22450.1 - 0.1 12.8 3.2 3.6 7.8 1.5 2.5 2 0 0 2 2 2 0 E7 protein, Early protein zf-XS PF03470.14 ETO22450.1 - 0.58 10.5 4.5 1.2 9.5 2.5 2.7 2 0 0 2 2 2 0 XS zinc finger domain DUF3464 PF11947.8 ETO22450.1 - 0.92 9.2 3.8 3.2 7.5 1.9 2.3 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 PBP1_TM PF14812.6 ETO22450.1 - 2.6 8.5 8.2 5 7.6 5.9 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3408 PF11888.8 ETO22450.1 - 5.2 7.2 11.3 0.72 10.0 6.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Inhibitor_I71 PF12628.7 ETO22450.1 - 8.6 6.2 9.9 20 5.0 2.7 2.6 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor Macoilin PF09726.9 ETO22451.1 - 2.3 6.7 19.0 3 6.3 19.0 1.2 1 0 0 1 1 1 0 Macoilin family SH2 PF00017.24 ETO22453.1 - 1e-06 28.7 1.2 2.3e-06 27.6 0.0 2.2 2 1 0 2 2 2 1 SH2 domain CDC45 PF02724.14 ETO22453.1 - 0.0075 14.6 7.5 0.0098 14.2 7.5 1.2 1 0 0 1 1 1 1 CDC45-like protein PTPRCAP PF15713.5 ETO22453.1 - 0.015 15.6 9.7 0.088 13.1 8.9 2.1 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated Herpes_IE2_3 PF03361.14 ETO22453.1 - 0.018 14.9 0.1 0.049 13.5 0.1 1.8 1 1 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 VIR_N PF15912.5 ETO22453.1 - 0.036 13.7 11.7 0.068 12.8 11.7 1.4 1 0 0 1 1 1 0 Virilizer, N-terminal PsaN PF05479.11 ETO22453.1 - 0.18 12.0 1.7 13 6.0 0.1 2.3 2 0 0 2 2 2 0 Photosystem I reaction centre subunit N (PSAN or PSI-N) PGA2 PF07543.12 ETO22453.1 - 0.81 9.7 12.1 1.7 8.6 12.1 1.5 1 0 0 1 1 1 0 Protein trafficking PGA2 Presenilin PF01080.17 ETO22453.1 - 2 7.1 12.2 3.3 6.4 12.2 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO22453.1 - 2.1 7.1 14.2 6.8 5.4 11.7 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Tub_N PF16322.5 ETO22456.1 - 0.11 12.8 26.8 0.17 12.3 26.8 1.2 1 0 0 1 1 1 0 Tubby N-terminal Lin-8 PF03353.15 ETO22456.1 - 0.15 11.6 23.1 0.19 11.3 23.1 1.0 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Menin PF05053.13 ETO22456.1 - 0.2 10.0 17.6 0.24 9.7 17.6 1.0 1 0 0 1 1 1 0 Menin SWI-SNF_Ssr4 PF08549.10 ETO22456.1 - 0.23 10.0 15.6 0.28 9.8 15.6 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) PAP1 PF08601.10 ETO22456.1 - 0.39 10.4 23.8 0.47 10.1 23.8 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 GREB1 PF15782.5 ETO22456.1 - 0.72 6.9 23.3 0.87 6.6 23.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RNA_pol_Rpb2_6 PF00562.28 ETO22456.1 - 0.85 8.6 7.0 0.96 8.4 7.0 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 6 PHC2_SAM_assoc PF16616.5 ETO22456.1 - 1.2 10.0 31.0 0.11 13.3 22.5 2.1 1 1 0 2 2 2 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Draxin PF15550.6 ETO22456.1 - 1.2 8.9 13.5 1.5 8.7 13.5 1.1 1 0 0 1 1 1 0 Draxin DUF4778 PF16008.5 ETO22456.1 - 1.3 9.1 13.2 1.6 8.7 13.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) DUF572 PF04502.13 ETO22456.1 - 1.8 8.1 24.0 2.1 7.9 24.0 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) SRP-alpha_N PF04086.13 ETO22456.1 - 2.7 7.9 23.9 3.3 7.6 23.9 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal BUD22 PF09073.10 ETO22456.1 - 2.8 7.2 31.0 3.5 6.9 31.0 1.0 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 ETO22456.1 - 3.1 6.2 25.4 3.9 5.9 25.4 1.0 1 0 0 1 1 1 0 Macoilin family Herpes_pp85 PF04637.12 ETO22456.1 - 4 5.7 13.2 5.7 5.2 13.2 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) FAM220 PF15487.6 ETO22456.1 - 7.4 6.1 18.1 9.2 5.8 18.1 1.1 1 0 0 1 1 1 0 FAM220 family SLC12 PF03522.15 ETO22456.1 - 7.4 5.5 16.3 9.7 5.1 16.3 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 ETO22456.1 - 7.8 5.2 26.3 10 4.8 26.3 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain CDC45 PF02724.14 ETO22456.1 - 9.5 4.4 25.4 11 4.1 25.4 1.0 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO22457.1 - 0.023 14.1 9.6 0.023 14.1 9.6 1.0 1 0 0 1 1 1 0 BUD22 eIF-3c_N PF05470.12 ETO22457.1 - 0.03 12.6 2.3 0.033 12.5 2.3 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DNA_pol_phi PF04931.13 ETO22457.1 - 0.21 9.7 28.9 0.27 9.3 28.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi TFB6 PF17110.5 ETO22457.1 - 0.75 9.5 8.1 1.3 8.8 8.1 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RRN3 PF05327.11 ETO22457.1 - 1.4 7.4 15.5 1.5 7.2 15.5 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SSV1_ORF_D-335 PF07935.11 ETO22458.1 - 0.071 13.4 0.5 0.11 12.8 0.5 1.3 1 0 0 1 1 1 0 ORF D-335-like protein UCR_14kD PF02271.16 ETO22458.1 - 0.1 12.5 0.9 0.17 11.9 0.9 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C reductase complex 14kD subunit UBX PF00789.20 ETO22459.1 - 5.2e-08 33.0 0.0 1.1e-07 31.9 0.0 1.5 1 0 0 1 1 1 1 UBX domain GREB1 PF15782.5 ETO22459.1 - 0.017 12.3 18.8 0.019 12.2 18.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 ETO22459.1 - 3.3 5.9 22.6 4.1 5.6 22.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Cwf_Cwc_15 PF04889.12 ETO22459.1 - 4.3 7.0 29.1 5.7 6.6 29.1 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein zf-C2H2 PF00096.26 ETO22460.1 - 0.0045 17.4 3.9 0.016 15.6 3.9 2.1 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ETO22460.1 - 0.0087 16.0 4.3 0.027 14.5 4.3 2.0 1 0 0 1 1 1 1 C2H2-type zinc finger zf-met PF12874.7 ETO22460.1 - 0.019 15.3 3.4 0.091 13.2 3.4 2.3 1 0 0 1 1 1 0 Zinc-finger of C2H2 type Methyltransf_12 PF08242.12 ETO22460.1 - 0.92 10.3 3.2 3.5 8.4 0.2 2.7 2 0 0 2 2 2 0 Methyltransferase domain zf-C2H2_4 PF13894.6 ETO22460.1 - 4.9 8.3 8.1 3.2 8.8 3.2 3.0 2 0 0 2 2 2 0 C2H2-type zinc finger DnaJ_C PF01556.18 ETO22461.1 - 3.4e-16 59.7 0.3 4.3e-16 59.3 0.3 1.1 1 0 0 1 1 1 1 DnaJ C terminal domain Phage_Treg PF04761.12 ETO22462.1 - 0.075 13.1 0.1 0.19 11.8 0.1 1.7 1 0 0 1 1 1 0 Lactococcus bacteriophage putative transcription regulator ArfGap PF01412.18 ETO22463.1 - 7.2e-32 109.9 1.5 1.8e-31 108.7 1.5 1.6 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf Hep_59 PF07052.11 ETO22463.1 - 0.41 11.4 4.1 0.96 10.2 4.1 1.6 1 0 0 1 1 1 0 Hepatocellular carcinoma-associated antigen 59 PH PF00169.29 ETO22464.1 - 2.8e-07 31.0 1.3 1.2e-05 25.8 1.5 2.6 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO22464.1 - 0.00021 21.5 0.1 0.00047 20.4 0.1 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 ETO22464.1 - 0.00044 20.5 0.1 0.00083 19.6 0.1 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3819 PF12842.7 ETO22464.1 - 0.0084 16.1 0.0 0.015 15.2 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3819) PH_11 PF15413.6 ETO22464.1 - 0.0098 16.3 1.5 0.018 15.4 0.8 1.8 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 ETO22464.1 - 0.056 13.3 0.1 0.11 12.4 0.1 1.4 1 0 0 1 1 1 0 Pleckstrin homology domain DUF3452 PF11934.8 ETO22465.1 - 0.048 13.2 0.0 0.062 12.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3452) SDA1 PF05285.12 ETO22466.1 - 0.00028 20.4 22.4 0.00032 20.2 22.4 1.1 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 ETO22466.1 - 0.00033 19.1 17.7 0.00042 18.7 17.7 1.1 1 0 0 1 1 1 1 CDC45-like protein SAPS PF04499.15 ETO22466.1 - 0.0049 15.7 10.5 0.0054 15.6 10.5 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Pex2_Pex12 PF04757.14 ETO22466.1 - 0.0054 16.3 0.0 0.041 13.5 0.0 2.0 1 1 0 1 1 1 1 Pex2 / Pex12 amino terminal region Nop14 PF04147.12 ETO22466.1 - 0.014 13.6 27.5 0.017 13.4 27.5 1.0 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO22466.1 - 0.017 13.9 4.5 0.02 13.7 4.5 1.2 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 ETO22466.1 - 0.026 13.0 25.9 0.035 12.6 25.9 1.1 1 0 0 1 1 1 0 Mpp10 protein Neur_chan_memb PF02932.16 ETO22466.1 - 0.052 13.6 2.3 0.07 13.2 2.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 ETO22466.1 - 0.065 12.0 13.7 0.085 11.6 13.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Mit_proteolip PF08039.11 ETO22466.1 - 0.14 12.6 0.0 0.22 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial proteolipid Zip PF02535.22 ETO22466.1 - 0.25 10.5 9.7 0.34 10.1 9.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 ETO22466.1 - 0.3 10.0 9.0 0.36 9.8 9.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PPL5 PF18168.1 ETO22466.1 - 0.49 9.6 13.0 0.61 9.3 13.0 1.1 1 0 0 1 1 1 0 Prim-pol family 5 FAM60A PF15396.6 ETO22466.1 - 0.61 10.0 7.8 0.85 9.6 7.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A TFIIF_alpha PF05793.12 ETO22466.1 - 0.67 8.5 32.9 0.84 8.2 32.9 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) V_ATPase_I PF01496.19 ETO22466.1 - 1.6 6.5 7.7 1.9 6.3 7.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tim54 PF11711.8 ETO22466.1 - 1.8 7.2 7.9 2.7 6.7 7.9 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 BUD22 PF09073.10 ETO22466.1 - 5.1 6.3 30.7 6.1 6.1 30.7 1.1 1 0 0 1 1 1 0 BUD22 Striatin PF08232.12 ETO22466.1 - 5.3 7.6 11.8 8 7.0 11.3 1.5 1 1 0 1 1 1 0 Striatin family Tom22 PF04281.13 ETO22466.1 - 6.3 6.6 26.8 0.047 13.5 10.8 2.1 1 1 1 2 2 2 0 Mitochondrial import receptor subunit Tom22 SpoIIIAH PF12685.7 ETO22466.1 - 7.5 6.3 17.1 11 5.7 17.1 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Nucleotid_trans PF03407.16 ETO22467.1 - 5.2e-22 78.9 0.0 8.5e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase DUF2178 PF09946.9 ETO22467.1 - 0.027 14.6 0.0 0.051 13.8 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2178) DEP PF00610.21 ETO22468.1 - 1.7e-17 63.2 0.1 2.8e-17 62.5 0.1 1.3 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Steroid_dh PF02544.16 ETO22469.1 - 3.7e-50 169.8 3.2 3.7e-50 169.8 3.2 1.7 2 0 0 2 2 2 1 3-oxo-5-alpha-steroid 4-dehydrogenase DUF1295 PF06966.12 ETO22469.1 - 9.4e-07 28.6 0.0 1.9e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) PEMT PF04191.13 ETO22469.1 - 0.003 17.9 0.1 0.011 16.1 0.1 2.0 1 0 0 1 1 1 1 Phospholipid methyltransferase ParA PF10609.9 ETO22470.1 - 9.4e-79 264.3 0.7 1.5e-78 263.7 0.7 1.3 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase CbiA PF01656.23 ETO22470.1 - 3.5e-13 49.7 0.1 5.4e-11 42.6 0.0 2.4 2 0 0 2 2 2 1 CobQ/CobB/MinD/ParA nucleotide binding domain AAA_31 PF13614.6 ETO22470.1 - 3.9e-10 39.9 0.4 1.7e-08 34.6 0.0 2.8 2 0 0 2 2 2 1 AAA domain MipZ PF09140.11 ETO22470.1 - 8.9e-07 28.5 0.5 1.4e-05 24.5 0.5 2.3 1 1 0 1 1 1 1 ATPase MipZ DUF971 PF06155.12 ETO22470.1 - 1.9e-05 25.2 0.1 7.3e-05 23.3 0.1 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF971) ArsA_ATPase PF02374.15 ETO22470.1 - 0.00017 20.9 1.9 0.0027 16.9 0.1 2.8 2 1 1 3 3 3 1 Anion-transporting ATPase CBP_BcsQ PF06564.12 ETO22470.1 - 0.00071 19.1 0.0 0.0024 17.4 0.0 1.8 1 1 0 1 1 1 1 Cellulose biosynthesis protein BcsQ VirC1 PF07015.11 ETO22470.1 - 0.015 14.6 0.0 0.03 13.6 0.0 1.5 1 0 0 1 1 1 0 VirC1 protein Fer4_NifH PF00142.18 ETO22470.1 - 0.019 14.4 0.0 0.042 13.3 0.0 1.8 1 1 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family DUF3915 PF13054.6 ETO22470.1 - 0.24 11.4 1.9 0.5 10.4 1.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3915) DUF4482 PF14818.6 ETO22470.1 - 0.25 12.2 3.2 0.47 11.3 3.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) Pkinase PF00069.25 ETO22471.1 - 5.4e-55 186.6 0.1 1.1e-54 185.6 0.1 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22471.1 - 1.2e-22 80.5 0.1 6.4e-13 48.6 0.1 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase EF-hand_7 PF13499.6 ETO22471.1 - 1.4e-10 41.4 4.1 8.8e-06 26.1 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO22471.1 - 8.4e-09 34.4 7.5 1.6e-06 27.3 0.6 3.0 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO22471.1 - 1.2e-05 25.0 3.9 2e-05 24.3 0.3 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO22471.1 - 0.00015 21.4 7.2 0.066 13.2 0.3 3.3 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO22471.1 - 0.00017 20.9 7.7 0.0011 18.4 0.9 2.7 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 ETO22471.1 - 0.0026 17.7 2.8 0.048 13.6 0.0 3.2 3 0 0 3 3 3 1 Cytoskeletal-regulatory complex EF hand APH PF01636.23 ETO22471.1 - 0.0064 16.4 0.7 0.011 15.6 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO22471.1 - 0.0079 15.6 0.2 0.018 14.4 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO22471.1 - 0.0097 14.7 4.5 0.029 13.2 4.5 2.0 1 1 0 1 1 1 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ETO22471.1 - 0.01 15.4 0.1 0.01 15.4 0.1 1.8 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Unstab_antitox PF09720.10 ETO22471.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Putative addiction module component GNAT_acetyltr_2 PF13718.6 ETO22471.1 - 0.66 9.3 0.0 0.66 9.3 0.0 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Presenilin PF01080.17 ETO22471.1 - 6.4 5.4 9.8 9.8 4.8 9.8 1.2 1 0 0 1 1 1 0 Presenilin PI3K_1B_p101 PF10486.9 ETO22472.1 - 9.9 3.8 14.8 11 3.7 14.1 1.4 1 1 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Aa_trans PF01490.18 ETO22473.1 - 4.5e-18 65.2 0.0 5.9e-18 64.8 0.0 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein TctB PF07331.11 ETO22473.1 - 0.15 12.3 4.7 0.33 11.2 0.2 2.8 2 1 1 3 3 3 0 Tripartite tricarboxylate transporter TctB family Aa_trans PF01490.18 ETO22474.1 - 4e-21 75.2 11.3 4.9e-21 74.9 11.3 1.0 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Pannexin_like PF12534.8 ETO22475.1 - 0.014 14.5 0.9 0.014 14.5 0.9 1.6 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Sigma70_ner PF04546.13 ETO22475.1 - 0.015 15.1 5.8 0.021 14.7 2.5 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region Sec62 PF03839.16 ETO22475.1 - 0.02 14.4 3.3 0.055 13.0 3.3 1.7 1 0 0 1 1 1 0 Translocation protein Sec62 Connexin PF00029.19 ETO22475.1 - 0.027 14.2 0.4 0.069 12.9 0.4 1.7 1 0 0 1 1 1 0 Connexin Ctr PF04145.15 ETO22475.1 - 0.082 13.5 0.4 1.8 9.2 0.0 2.9 2 0 0 2 2 2 0 Ctr copper transporter family Neur_chan_memb PF02932.16 ETO22475.1 - 0.083 12.9 0.2 0.2 11.7 0.2 1.7 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RR_TM4-6 PF06459.12 ETO22475.1 - 0.11 12.3 7.6 0.17 11.7 7.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ETO22475.1 - 6.7 6.7 15.0 11 6.1 15.0 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 CDC45 PF02724.14 ETO22475.1 - 8.1 4.6 10.0 12 4.1 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 ETO22475.1 - 8.3 6.7 10.5 18 5.6 10.5 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Tim54 PF11711.8 ETO22475.1 - 8.8 5.0 10.6 13 4.4 10.6 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SKA1 PF07160.12 ETO22476.1 - 0.002 18.1 1.4 0.0084 16.0 1.0 2.2 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 1 GldM_N PF12081.8 ETO22476.1 - 0.025 14.7 2.5 0.05 13.7 2.5 1.5 1 0 0 1 1 1 0 GldM N-terminal domain PriC PF07445.12 ETO22476.1 - 0.089 12.7 4.9 0.18 11.7 4.9 1.5 1 1 0 1 1 1 0 Primosomal replication protein priC cNMP_binding PF00027.29 ETO22476.1 - 0.15 12.1 0.0 0.31 11.1 0.0 1.5 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain eIF3_p135 PF12807.7 ETO22476.1 - 0.2 11.7 0.1 0.2 11.7 0.1 2.5 2 1 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 DUF3332 PF11810.8 ETO22476.1 - 0.35 10.5 4.0 0.66 9.6 1.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3332) Phe_tRNA-synt_N PF02912.18 ETO22476.1 - 0.35 10.8 4.5 0.99 9.4 4.5 1.8 1 0 0 1 1 1 0 Aminoacyl tRNA synthetase class II, N-terminal domain AAA_23 PF13476.6 ETO22476.1 - 0.6 10.6 8.4 1.1 9.8 8.3 1.5 1 1 0 1 1 1 0 AAA domain Pkinase PF00069.25 ETO22478.1 - 7.6e-08 32.0 0.0 9.5e-08 31.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain GPAT_N PF14829.6 ETO22481.1 - 0.17 11.9 2.5 0.27 11.2 1.5 1.9 1 1 1 2 2 2 0 Glycerol-3-phosphate acyltransferase N-terminal Vps16_N PF04841.13 ETO22482.1 - 3.5e-08 32.6 0.1 4.5e-08 32.3 0.1 1.1 1 0 0 1 1 1 1 Vps16, N-terminal region Chlam_PMP PF02415.17 ETO22483.1 - 9.4e-05 22.7 39.9 0.12 12.9 0.6 9.6 10 0 0 10 10 10 6 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat ETRAMP PF09716.10 ETO22484.1 - 0.13 12.4 0.9 1.6 8.8 0.0 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Radical_SAM PF04055.21 ETO22485.1 - 7.8e-11 42.6 0.1 6.4e-10 39.6 0.1 2.1 1 1 0 1 1 1 1 Radical SAM superfamily Fer4_14 PF13394.6 ETO22485.1 - 4.2e-05 23.7 0.4 0.00015 21.9 0.4 1.9 1 1 0 1 1 1 1 4Fe-4S single cluster domain Helicase_C PF00271.31 ETO22486.1 - 4.4e-24 85.0 0.0 1.1e-23 83.7 0.0 1.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO22486.1 - 1.9e-15 57.1 0.0 6.2e-15 55.4 0.0 1.7 2 0 0 2 2 2 1 DEAD/DEAH box helicase zf-RING_11 PF17123.5 ETO22487.1 - 1.2e-07 31.3 1.0 3.2e-07 30.0 1.0 1.7 1 1 0 1 1 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO22487.1 - 8.5e-06 25.5 2.0 1.4e-05 24.9 2.0 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO22487.1 - 5.9e-05 23.3 1.7 9.1e-05 22.7 1.7 1.3 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO22487.1 - 9.9e-05 22.1 1.5 0.00017 21.4 1.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO22487.1 - 0.00025 21.0 1.9 0.00064 19.7 1.9 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO22487.1 - 0.0004 20.3 0.9 0.00071 19.5 0.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain RNF220 PF15926.5 ETO22487.1 - 0.0046 16.6 1.9 0.005 16.5 1.9 1.0 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 zf-rbx1 PF12678.7 ETO22487.1 - 0.011 16.0 1.7 0.028 14.7 1.7 1.7 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETO22487.1 - 0.012 15.4 1.3 0.018 14.9 1.3 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO22487.1 - 0.16 11.8 2.7 0.46 10.4 2.7 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 TPR_12 PF13424.6 ETO22488.1 - 1.3e-37 128.0 4.9 9.2e-19 67.5 0.1 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22488.1 - 2.2e-30 103.2 27.8 1.6e-08 34.0 0.8 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22488.1 - 3.1e-26 90.4 3.9 9.8e-06 25.3 0.0 5.8 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22488.1 - 3.7e-23 79.7 23.7 5.9e-06 26.1 1.5 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22488.1 - 7.6e-22 75.6 21.0 1.1e-05 25.1 0.3 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22488.1 - 5.5e-19 66.7 8.5 3.5e-05 23.5 0.0 5.3 6 0 0 6 6 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22488.1 - 3e-15 55.6 21.6 1.4e-05 24.7 0.3 6.3 6 1 0 6 6 6 4 TPR repeat SNAP PF14938.6 ETO22488.1 - 4.6e-09 36.1 3.5 6.5e-08 32.3 0.2 2.7 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 ETO22488.1 - 3.1e-07 30.6 0.0 19 6.4 0.0 5.6 5 1 1 6 6 5 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO22488.1 - 8.1e-07 29.2 0.1 1.7e-06 28.2 0.1 1.5 1 0 0 1 1 1 1 Caspase domain TPR_6 PF13174.6 ETO22488.1 - 2.5e-06 27.7 0.9 4.4 8.2 0.1 5.8 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22488.1 - 3.3e-05 24.0 3.9 1.8 9.1 0.0 5.0 5 1 2 7 7 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO22488.1 - 4.4e-05 22.9 3.3 0.6 9.6 0.1 4.5 4 0 0 4 4 4 1 SHNi-TPR TPR_16 PF13432.6 ETO22488.1 - 8.8e-05 23.1 0.0 2 9.1 0.0 4.4 4 2 0 4 4 3 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO22488.1 - 0.00016 21.5 8.1 1.2 9.0 0.5 4.6 2 1 2 4 4 4 2 Domain of unknown function (DUF5113) MIT PF04212.18 ETO22488.1 - 0.00032 20.7 10.8 0.55 10.3 0.5 5.7 4 1 1 5 5 5 1 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO22488.1 - 0.0022 18.2 7.8 0.65 10.3 0.7 3.3 3 0 0 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_MalT PF17874.1 ETO22488.1 - 0.0042 16.5 0.0 0.0073 15.7 0.0 1.4 1 0 0 1 1 1 1 MalT-like TPR region POTRA_1 PF08478.10 ETO22488.1 - 0.0072 16.6 0.1 0.023 15.0 0.1 1.8 1 0 0 1 1 1 1 POTRA domain, FtsQ-type TPR_3 PF07720.12 ETO22488.1 - 0.013 15.4 6.8 2.6 8.1 0.3 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETO22488.1 - 0.016 15.3 0.9 0.3 11.1 0.2 2.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF3856) RPN7 PF10602.9 ETO22488.1 - 0.034 13.9 5.5 5.7 6.6 0.1 3.9 2 1 2 4 4 4 0 26S proteasome subunit RPN7 TPR_19 PF14559.6 ETO22488.1 - 0.042 14.4 0.0 22 5.7 0.0 3.4 3 0 0 3 3 2 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO22488.1 - 0.15 11.7 4.1 29 4.4 0.1 4.6 2 1 1 3 3 3 0 Helix-turn-helix bacterial domain NRBF2_MIT PF17169.4 ETO22488.1 - 0.68 10.2 7.4 1.1 9.6 0.1 3.8 3 1 1 4 4 3 0 MIT domain of nuclear receptor-binding factor 2 PPR PF01535.20 ETO22488.1 - 0.77 10.1 7.1 19 5.8 0.1 5.0 5 0 0 5 5 4 0 PPR repeat WD40 PF00400.32 ETO22489.1 - 5.4e-36 122.0 9.3 2.7e-08 34.3 0.0 6.7 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22489.1 - 1.6e-15 57.1 2.0 0.0065 16.7 0.0 6.3 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22489.1 - 2.7e-10 39.7 1.0 0.05 12.6 0.0 4.9 2 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO22489.1 - 1.1e-07 31.5 0.0 0.029 13.7 0.0 3.0 3 0 0 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO22489.1 - 0.00014 21.7 4.8 23 5.1 0.1 5.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO22489.1 - 0.00069 19.0 2.2 0.012 15.0 0.2 3.3 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Str_synth PF03088.16 ETO22489.1 - 0.041 14.0 1.0 34 4.6 0.0 4.8 3 2 3 6 6 6 0 Strictosidine synthase DUF2442 PF10387.9 ETO22489.1 - 0.061 13.6 0.1 11 6.4 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF2442) CsgF PF10614.9 ETO22489.1 - 0.077 13.2 0.7 0.29 11.3 0.0 2.4 3 0 0 3 3 3 0 Type VIII secretion system (T8SS), CsgF protein DUF5570 PF17731.1 ETO22489.1 - 0.81 9.8 7.3 2.2 8.4 0.2 3.5 3 1 2 5 5 5 0 Family of unknown function (DUF5570) Rtt102p PF09510.10 ETO22490.1 - 0.44 10.8 4.0 0.72 10.1 4.0 1.3 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein RL10P_insert PF17777.1 ETO22491.1 - 3e-15 56.0 0.1 6.3e-15 54.9 0.1 1.5 1 0 0 1 1 1 1 Insertion domain in 60S ribosomal protein L10P Ribosomal_60s PF00428.19 ETO22491.1 - 0.00025 21.5 15.8 0.0054 17.3 15.8 2.4 1 1 0 1 1 1 1 60s Acidic ribosomal protein Ribosomal_L10 PF00466.20 ETO22492.1 - 5.6e-11 42.5 0.1 9.7e-11 41.7 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L10 TPR_12 PF13424.6 ETO22494.1 - 6.4e-25 87.3 1.3 2.8e-13 50.0 0.3 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22494.1 - 2.7e-18 65.2 0.0 6.4e-06 25.9 0.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22494.1 - 2.1e-14 52.6 21.0 7.8e-09 35.0 0.4 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22494.1 - 2.3e-14 52.3 3.7 1.3e-06 28.0 0.0 3.9 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22494.1 - 3.7e-14 51.6 10.0 4.5e-07 29.5 0.1 4.1 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22494.1 - 5.3e-13 48.1 20.1 1.3e-07 31.3 0.8 4.8 5 0 0 5 5 5 2 Tetratricopeptide repeat MIT PF04212.18 ETO22494.1 - 1.5e-08 34.6 3.5 0.0021 18.1 0.9 2.9 2 0 0 2 2 2 2 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO22494.1 - 9.7e-05 22.5 5.6 0.13 12.7 0.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22494.1 - 0.00023 21.6 0.7 0.44 11.3 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22494.1 - 0.00055 19.6 13.6 0.0098 15.6 0.2 4.9 3 2 2 5 5 5 1 TPR repeat TPR_3 PF07720.12 ETO22494.1 - 0.03 14.3 4.4 1.1 9.4 1.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22494.1 - 0.034 14.9 0.0 6.7 7.8 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22494.1 - 0.041 14.6 0.0 6.2 7.6 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO22494.1 - 0.048 13.4 5.6 0.075 12.8 4.8 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) DUF627 PF04781.12 ETO22494.1 - 0.076 13.0 0.1 0.21 11.6 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF627) DUF5113 PF17140.4 ETO22494.1 - 0.12 12.1 5.8 2.9 7.7 0.1 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) NSF PF02071.20 ETO22494.1 - 2.6 9.2 9.6 14 7.0 0.7 4.5 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat Peptidase_C12 PF01088.21 ETO22495.1 - 0.093 12.5 0.7 0.74 9.5 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase, family 1 GWT1 PF06423.12 ETO22495.1 - 6.9 6.8 11.7 0.26 11.4 0.3 2.4 2 1 0 2 2 2 0 GWT1 Pkinase PF00069.25 ETO22496.1 - 1.6e-05 24.5 0.0 2e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain MRF_C2 PF13888.6 ETO22496.1 - 0.038 13.9 0.1 0.051 13.5 0.1 1.1 1 0 0 1 1 1 0 Myelin gene regulatory factor C-terminal domain 2 HD-ZIP_N PF04618.12 ETO22497.1 - 3.7 8.1 6.3 1e+02 3.4 6.2 2.2 1 1 0 1 1 1 0 HD-ZIP protein N terminus DEP PF00610.21 ETO22498.1 - 6.2e-12 45.4 1.1 2.4e-11 43.5 0.2 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DASH_Dad3 PF08656.10 ETO22498.1 - 0.054 13.6 2.4 0.09 12.9 0.1 2.5 3 0 0 3 3 3 0 DASH complex subunit Dad3 dCache_1 PF02743.18 ETO22499.1 - 0.0029 17.4 1.6 0.0083 15.9 1.6 1.8 1 1 0 1 1 1 1 Cache domain RTP801_C PF07809.11 ETO22499.1 - 0.075 12.9 0.5 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 RTP801 C-terminal region LapA_dom PF06305.11 ETO22499.1 - 6.3 6.7 9.8 1.7 8.5 3.9 2.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF4407 PF14362.6 ETO22501.1 - 2.2 7.5 11.1 3.3 7.0 11.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2407_C PF13373.6 ETO22501.1 - 5.6 7.1 10.7 5.3 7.2 8.6 2.1 1 1 1 2 2 2 0 DUF2407 C-terminal domain Pyr_redox_2 PF07992.14 ETO22502.1 - 1.9e-48 165.2 1.3 2.6e-48 164.8 1.3 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETO22502.1 - 4e-34 117.2 1.3 6.9e-34 116.4 0.1 2.0 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ETO22502.1 - 6.4e-21 74.7 1.4 1.4e-20 73.7 0.3 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO22502.1 - 5.8e-11 42.2 0.2 9.5e-11 41.5 0.2 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO22502.1 - 8.4e-08 31.7 0.2 0.00037 19.8 0.0 2.1 2 0 0 2 2 2 2 L-lysine 6-monooxygenase (NADPH-requiring) FAD_binding_3 PF01494.19 ETO22502.1 - 0.0002 20.7 3.1 0.12 11.6 0.1 3.0 2 2 1 3 3 3 2 FAD binding domain Amino_oxidase PF01593.24 ETO22502.1 - 0.00073 18.9 0.3 0.12 11.7 0.1 2.3 1 1 1 2 2 2 2 Flavin containing amine oxidoreductase HI0933_like PF03486.14 ETO22502.1 - 0.0014 17.4 3.1 0.68 8.6 0.1 3.1 2 1 1 3 3 3 2 HI0933-like protein Mqo PF06039.15 ETO22502.1 - 0.0032 16.1 1.8 0.075 11.6 0.2 2.2 1 1 1 2 2 2 1 Malate:quinone oxidoreductase (Mqo) 3HCDH_N PF02737.18 ETO22502.1 - 0.0059 16.5 1.3 0.05 13.5 0.2 2.7 3 0 0 3 3 3 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain DAO PF01266.24 ETO22502.1 - 0.0083 15.8 4.1 1.6 8.2 0.1 3.0 3 0 0 3 3 3 2 FAD dependent oxidoreductase AlaDh_PNT_C PF01262.21 ETO22502.1 - 0.0096 15.2 0.4 0.018 14.4 0.4 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain FAD_binding_2 PF00890.24 ETO22502.1 - 0.69 8.9 4.4 4 6.4 0.1 2.8 2 1 1 3 3 3 0 FAD binding domain PARP PF00644.20 ETO22503.1 - 3.5e-08 33.3 0.2 1.5e-07 31.2 0.0 1.8 1 1 1 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain zf-RING_9 PF13901.6 ETO22504.1 - 2.1e-15 57.3 2.7 3.2e-11 43.6 0.5 2.4 2 0 0 2 2 2 2 Putative zinc-RING and/or ribbon Med27 PF11571.8 ETO22504.1 - 0.75 10.2 4.1 27 5.2 1.0 2.9 2 0 0 2 2 2 0 Mediator complex subunit 27 DUF1272 PF06906.11 ETO22504.1 - 3.5 7.8 7.8 1.6 8.9 4.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1272) LIM PF00412.22 ETO22504.1 - 4.6 7.5 15.6 7.2 6.9 5.1 3.8 4 0 0 4 4 4 0 LIM domain Mito_carr PF00153.27 ETO22507.1 - 8.1e-52 173.1 0.7 1.6e-18 66.4 0.0 3.3 3 1 0 3 3 3 3 Mitochondrial carrier protein Glyco_transf_28 PF03033.20 ETO22508.1 - 0.32 11.0 1.7 0.83 9.7 1.7 1.6 1 0 0 1 1 1 0 Glycosyltransferase family 28 N-terminal domain DUF3685 PF12452.8 ETO22508.1 - 2.5 7.8 9.8 0.78 9.4 6.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3685) HIGH_NTase1 PF05636.11 ETO22509.1 - 0.00011 21.5 0.2 0.00016 21.0 0.2 1.1 1 0 0 1 1 1 1 HIGH Nucleotidyl Transferase DUF1871 PF08958.10 ETO22509.1 - 0.16 12.3 0.0 0.41 11.0 0.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF1871) Jnk-SapK_ap_N PF09744.9 ETO22510.1 - 0.0074 16.5 4.1 0.0074 16.5 4.1 5.3 3 2 2 5 5 5 2 JNK_SAPK-associated protein-1 DUF1841 PF08897.11 ETO22510.1 - 0.047 13.7 6.0 0.079 13.0 0.3 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF1841) Xlink PF00193.17 ETO22510.1 - 0.19 12.1 1.8 0.29 11.5 0.4 2.2 2 0 0 2 2 2 0 Extracellular link domain Flg_hook PF02120.16 ETO22510.1 - 0.23 11.4 0.1 0.23 11.4 0.1 3.3 2 1 0 2 2 2 0 Flagellar hook-length control protein FliK YmgD PF16456.5 ETO22513.1 - 0.032 14.3 0.1 0.066 13.3 0.1 1.5 1 0 0 1 1 1 0 YmgD protein LRR_9 PF14580.6 ETO22514.1 - 8.8e-20 70.9 17.5 9.1e-19 67.6 7.8 3.0 2 1 1 3 3 3 2 Leucine-rich repeat LRR_4 PF12799.7 ETO22514.1 - 2.2e-15 56.5 42.4 9.5e-07 29.1 4.6 5.3 4 1 1 5 5 5 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO22514.1 - 3.4e-10 39.5 25.2 4.1e-05 23.3 8.7 3.5 1 1 2 3 3 3 3 Leucine rich repeat SMC_Nse1 PF07574.13 ETO22514.1 - 0.2 11.5 5.8 0.11 12.3 2.6 2.2 2 1 0 2 2 2 0 Nse1 non-SMC component of SMC5-6 complex LRR_6 PF13516.6 ETO22514.1 - 9 6.6 17.7 9.5 6.6 0.2 5.2 5 0 0 5 5 5 0 Leucine Rich repeat NPV_P10 PF05531.12 ETO22515.1 - 0.035 14.6 0.5 0.035 14.6 0.5 18.8 9 5 8 18 18 18 0 Nucleopolyhedrovirus P10 protein S_locus_glycop PF00954.20 ETO22515.1 - 0.18 12.3 2.3 3.7 8.1 2.3 3.5 1 0 0 1 1 1 0 S-locus glycoprotein domain TPR_2 PF07719.17 ETO22517.1 - 4e-25 85.9 14.7 0.003 17.6 0.1 7.9 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22517.1 - 2.6e-22 77.7 20.4 0.00044 20.0 0.0 8.1 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22517.1 - 2e-18 65.0 14.1 0.0035 17.4 0.0 7.6 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22517.1 - 2.5e-17 62.1 0.2 0.054 14.3 0.0 6.8 3 1 3 6 6 6 4 Tetratricopeptide repeat TPR_12 PF13424.6 ETO22517.1 - 7.5e-17 61.4 12.1 0.00022 21.4 0.7 6.5 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22517.1 - 3.4e-14 53.2 0.6 0.00078 20.0 0.1 5.1 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22517.1 - 2.2e-13 49.7 10.5 0.00017 21.2 0.1 5.7 3 1 2 5 5 5 4 TPR repeat TPR_17 PF13431.6 ETO22517.1 - 6.8e-11 41.8 12.1 0.017 15.5 0.2 7.3 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22517.1 - 1.1e-08 34.4 13.9 0.36 11.0 0.2 8.0 8 0 0 8 8 7 3 Tetratricopeptide repeat SAM_1 PF00536.30 ETO22517.1 - 8.2e-08 32.6 0.3 1.7e-07 31.5 0.3 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO22517.1 - 9.7e-08 32.0 0.2 3.9e-07 30.1 0.3 2.1 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) TPR_19 PF14559.6 ETO22517.1 - 3.2e-07 30.7 3.6 0.66 10.5 0.0 5.4 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22517.1 - 9.7e-07 28.5 10.9 2.4 8.1 0.0 7.5 7 0 0 7 7 7 2 Tetratricopeptide repeat MIT PF04212.18 ETO22517.1 - 6e-06 26.2 6.1 18 5.5 0.0 6.8 6 0 0 6 6 6 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO22517.1 - 0.015 15.9 10.7 0.32 11.7 0.2 5.7 7 0 0 7 7 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO22517.1 - 0.032 14.4 0.8 6 7.1 0.0 4.1 4 1 2 6 6 6 0 Tetratricopeptide repeat NCD1 PF04904.13 ETO22517.1 - 0.041 13.9 0.3 0.15 12.1 0.1 2.1 2 0 0 2 2 2 0 NAB conserved region 1 (NCD1) GCIP PF13324.6 ETO22517.1 - 1.1 8.8 13.0 0.052 13.2 5.1 2.6 3 0 0 3 3 3 0 Grap2 and cyclin-D-interacting Cwf_Cwc_15 PF04889.12 ETO22517.1 - 6.1 6.5 39.4 0.044 13.5 17.1 4.0 4 0 0 4 4 4 0 Cwf15/Cwc15 cell cycle control protein EMG1 PF03587.14 ETO22518.1 - 2.8e-37 128.3 0.1 3e-37 128.2 0.1 1.0 1 0 0 1 1 1 1 EMG1/NEP1 methyltransferase Pkinase PF00069.25 ETO22519.1 - 1.5e-25 90.0 0.2 7.8e-25 87.7 0.2 1.8 1 1 0 1 1 1 1 Protein kinase domain Plectin PF00681.20 ETO22519.1 - 0.047 13.6 0.0 0.08 12.8 0.0 1.3 1 0 0 1 1 1 0 Plectin repeat Neur_chan_memb PF02932.16 ETO22521.1 - 0.0026 17.9 5.2 0.07 13.2 1.0 2.4 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF2368 PF10166.9 ETO22521.1 - 0.87 9.2 4.4 2.9 7.5 4.4 1.9 1 0 0 1 1 1 0 Uncharacterised conserved protein (DUF2368) PEX11 PF05648.14 ETO22522.1 - 0.17 11.4 2.7 0.99 8.8 0.3 2.3 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) AAA_11 PF13086.6 ETO22522.1 - 3.2 7.5 12.1 0.22 11.2 1.3 2.2 2 0 0 2 2 2 0 AAA domain DEP PF00610.21 ETO22523.1 - 1.7e-17 63.2 0.1 3.5e-17 62.2 0.1 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_7 PF13499.6 ETO22523.1 - 1.2e-06 28.8 0.5 5.2e-05 23.6 0.5 3.0 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO22523.1 - 8e-05 22.3 1.2 0.015 15.2 0.1 3.5 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 ETO22523.1 - 0.00078 19.2 0.3 0.027 14.3 0.0 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO22523.1 - 0.00091 18.6 0.8 0.014 14.9 0.3 2.6 2 0 0 2 2 2 1 EF hand EF-hand_1 PF00036.32 ETO22523.1 - 0.0018 17.7 0.1 0.0018 17.7 0.1 3.7 4 0 0 4 4 4 2 EF hand PHO4 PF01384.20 ETO22524.1 - 0.61 9.1 7.8 0.32 10.0 5.7 1.4 1 1 0 1 1 1 0 Phosphate transporter family Vma12 PF11712.8 ETO22524.1 - 4.7 7.3 4.9 0.91 9.6 0.2 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF4064 PF13273.6 ETO22524.1 - 5.1 7.4 16.0 0.16 12.2 5.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) Choline_transpo PF04515.12 ETO22525.1 - 2.2e-38 132.3 13.0 2.5e-38 132.1 13.0 1.0 1 0 0 1 1 1 1 Plasma-membrane choline transporter Phage_holin_2_4 PF16082.5 ETO22525.1 - 0.7 9.7 7.3 1.3 8.8 5.8 2.2 3 0 0 3 3 3 0 Bacteriophage holin family, superfamily II-like Presenilin PF01080.17 ETO22527.1 - 0.00089 18.1 5.9 0.0012 17.7 5.9 1.1 1 0 0 1 1 1 1 Presenilin Pkinase PF00069.25 ETO22527.1 - 0.0043 16.4 0.4 0.011 15.1 0.0 1.8 1 1 1 2 2 2 1 Protein kinase domain DUF4407 PF14362.6 ETO22527.1 - 0.018 14.4 1.3 0.026 13.9 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Raftlin PF15250.6 ETO22527.1 - 0.034 12.9 6.4 0.039 12.7 6.4 1.1 1 0 0 1 1 1 0 Raftlin Ndc1_Nup PF09531.10 ETO22527.1 - 0.18 10.4 1.3 0.21 10.2 1.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Menin PF05053.13 ETO22527.1 - 0.66 8.3 13.0 0.87 7.9 13.0 1.1 1 0 0 1 1 1 0 Menin Peroxin-3 PF04882.12 ETO22527.1 - 0.75 8.7 13.2 1.1 8.2 13.2 1.2 1 0 0 1 1 1 0 Peroxin-3 MDFI PF15316.6 ETO22527.1 - 0.92 9.6 8.3 1.9 8.6 8.3 1.5 1 0 0 1 1 1 0 MyoD family inhibitor SLC12 PF03522.15 ETO22527.1 - 1.1 8.2 12.5 1.6 7.7 12.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Macoilin PF09726.9 ETO22527.1 - 1.1 7.7 13.6 1.6 7.2 13.6 1.1 1 0 0 1 1 1 0 Macoilin family Hid1 PF12722.7 ETO22527.1 - 1.4 7.0 15.5 1.9 6.5 15.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Suf PF05843.14 ETO22527.1 - 1.9 8.4 10.2 3.2 7.7 10.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 ETO22527.1 - 2.1 8.4 7.2 3.4 7.7 7.2 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO22527.1 - 7.6 4.7 15.4 10 4.3 15.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Med3 PF11593.8 ETO22527.1 - 9 5.4 32.0 14 4.8 32.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Pkinase PF00069.25 ETO22528.1 - 4.9e-38 131.0 0.0 1.1e-37 129.8 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22528.1 - 3.3e-18 65.9 0.0 1.1e-17 64.2 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ETO22528.1 - 0.00057 20.5 0.4 0.00097 19.8 0.4 1.4 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ETO22528.1 - 0.028 13.8 0.0 0.038 13.3 0.0 1.2 1 0 0 1 1 1 0 Kinase-like Kdo PF06293.14 ETO22528.1 - 0.031 13.6 0.0 0.17 11.2 0.0 1.9 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO22528.1 - 0.056 13.4 0.0 0.22 11.4 0.0 1.8 2 0 0 2 2 2 0 Phosphotransferase enzyme family WD40 PF00400.32 ETO22529.1 - 5.2e-123 397.4 51.3 7.9e-10 39.2 0.3 14.4 14 0 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22529.1 - 4e-40 136.0 7.4 0.0016 18.7 0.0 12.3 1 1 12 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22529.1 - 2.7e-23 82.4 13.6 0.19 10.6 0.0 13.2 2 1 11 13 13 13 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO22529.1 - 2.5e-16 59.9 2.3 0.012 15.0 0.0 7.7 2 2 4 8 8 8 5 WD40-like domain Frtz PF11768.8 ETO22529.1 - 4.1e-11 41.9 0.4 0.0088 14.4 0.0 6.6 2 2 4 7 7 7 4 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO22529.1 - 1.4e-06 28.1 19.2 19 5.3 0.2 10.2 11 0 0 11 11 11 0 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO22529.1 - 1.6e-05 24.4 0.2 4.4e-05 23.0 0.2 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DUF727 PF05303.12 ETO22529.1 - 4.2e-05 23.6 2.5 13 5.9 0.0 7.9 3 2 6 9 9 9 0 Protein of unknown function (DUF727) TolB_N PF04052.13 ETO22529.1 - 0.00017 21.8 0.1 96 3.2 0.0 6.9 7 0 0 7 7 7 0 TolB amino-terminal domain Pentapeptide_4 PF13599.6 ETO22529.1 - 0.00045 20.3 0.0 0.0012 19.0 0.0 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO22529.1 - 0.0033 16.0 2.2 0.94 7.9 0.0 4.0 2 2 1 4 4 4 1 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO22529.1 - 0.029 14.5 0.0 0.18 12.0 0.0 2.3 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Gmad1 PF10647.9 ETO22529.1 - 0.19 11.4 7.1 10 5.8 0.2 4.9 3 2 1 4 4 4 0 Lipoprotein LpqB beta-propeller domain Peptidase_M7 PF02031.16 ETO22529.1 - 0.25 11.5 1.9 34 4.5 0.0 4.8 2 2 0 3 3 3 0 Streptomyces extracellular neutral proteinase (M7) family zf-H2C2_2 PF13465.6 ETO22531.1 - 0.076 13.5 0.1 0.26 11.8 0.1 2.0 1 0 0 1 1 1 0 Zinc-finger double domain Kelch_4 PF13418.6 ETO22533.1 - 2.2e-18 66.0 0.0 0.00021 21.2 0.0 4.2 4 0 0 4 4 4 4 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO22533.1 - 1.7e-12 47.3 4.7 7.1e-09 35.7 0.0 4.6 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO22533.1 - 2.3e-12 46.6 0.1 0.014 15.3 0.0 4.4 4 0 0 4 4 4 4 Kelch motif Kelch_6 PF13964.6 ETO22533.1 - 4.3e-09 36.3 0.0 0.3 11.4 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO22533.1 - 5.5e-07 29.1 0.2 0.0013 18.2 0.0 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO22533.1 - 5.5e-05 23.0 0.1 0.042 13.8 0.1 3.5 3 0 0 3 3 3 1 Kelch motif Orthopox_B11R PF07033.11 ETO22533.1 - 0.073 12.9 7.0 0.12 12.2 7.0 1.3 1 0 0 1 1 1 0 Orthopoxvirus B11R protein zf-C2H2_3rep PF18868.1 ETO22533.1 - 0.13 12.9 0.1 0.21 12.3 0.1 1.3 1 0 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats DUF3752 PF12572.8 ETO22534.1 - 0.00034 21.2 1.6 0.00066 20.2 1.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3752) DUF2591 PF10765.9 ETO22534.1 - 0.0044 17.3 0.1 0.012 15.9 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2591) Peptidase_C14 PF00656.22 ETO22535.1 - 8.8e-14 52.1 1.0 2.4e-13 50.6 1.0 1.8 1 0 0 1 1 1 1 Caspase domain Kelch_4 PF13418.6 ETO22535.1 - 2.7e-07 30.5 0.0 0.0016 18.4 0.0 3.1 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO22535.1 - 7.5e-06 25.4 10.7 6.4e-05 22.5 0.4 3.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO22535.1 - 8.6e-05 22.4 7.8 0.33 11.0 1.9 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO22535.1 - 0.0003 21.0 10.0 0.079 13.3 0.2 5.2 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 ETO22535.1 - 0.024 14.6 10.1 0.076 13.0 0.4 5.3 6 0 0 6 6 6 0 Kelch motif Lsm_interact PF05391.11 ETO22535.1 - 0.24 10.9 1.3 7.3 6.2 0.0 2.7 2 0 0 2 2 2 0 Lsm interaction motif SAM_1 PF00536.30 ETO22536.1 - 1.8e-06 28.3 1.1 3e-06 27.6 1.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO22536.1 - 6.7e-06 26.0 1.9 1.4e-05 25.0 1.7 1.6 1 1 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DcpS_C PF11969.8 ETO22537.1 - 0.035 14.6 3.0 0.085 13.3 0.3 2.1 2 0 0 2 2 2 0 Scavenger mRNA decapping enzyme C-term binding TFIIB PF00382.19 ETO22538.1 - 1.5e-16 60.2 0.3 2.6e-13 49.8 0.1 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat BRF1 PF07741.13 ETO22538.1 - 4.6e-09 36.5 17.3 4.9e-08 33.2 3.8 2.6 2 0 0 2 2 2 2 Brf1-like TBP-binding domain SR-25 PF10500.9 ETO22538.1 - 5.9e-05 22.8 10.7 5.9e-05 22.8 10.7 1.6 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Cyclin_N PF00134.23 ETO22538.1 - 0.0029 17.4 0.1 0.25 11.1 0.0 2.6 2 0 0 2 2 2 1 Cyclin, N-terminal domain IMUP PF15761.5 ETO22538.1 - 0.031 15.0 9.9 0.073 13.8 9.9 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF3874 PF12990.7 ETO22538.1 - 0.1 13.0 0.0 0.25 11.7 0.0 1.7 1 0 0 1 1 1 0 Domain of unknonw function from B. Theta Gene description (DUF3874) CLN3 PF02487.17 ETO22538.1 - 1.1 8.2 3.7 1.4 7.9 3.2 1.4 1 1 0 1 1 1 0 CLN3 protein ANTH PF07651.16 ETO22539.1 - 0.043 12.8 3.4 0.56 9.1 0.5 2.1 2 0 0 2 2 2 0 ANTH domain DUF809 PF05663.11 ETO22539.1 - 0.13 12.4 4.0 0.14 12.3 1.4 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF809) TFB6 PF17110.5 ETO22539.1 - 0.15 11.8 2.5 0.34 10.6 2.5 1.6 1 1 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH 7TM_GPCR_Srv PF10323.9 ETO22540.1 - 0.0057 16.0 6.6 0.0057 16.0 6.6 1.8 1 1 1 2 2 2 2 Serpentine type 7TM GPCR chemoreceptor Srv DUF4381 PF14316.6 ETO22540.1 - 0.0073 16.6 0.1 0.013 15.7 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) DUF3278 PF11683.8 ETO22540.1 - 0.028 14.5 4.9 0.034 14.2 3.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3278) MLANA PF14991.6 ETO22540.1 - 0.031 14.6 0.1 0.069 13.4 0.1 1.6 1 0 0 1 1 1 0 Protein melan-A DUF2232 PF09991.9 ETO22540.1 - 0.053 12.7 3.0 0.069 12.3 2.3 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2232) DUF202 PF02656.15 ETO22540.1 - 0.11 13.0 0.4 0.25 11.8 0.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF202) TrbC PF04956.13 ETO22540.1 - 0.53 10.5 3.2 2.2 8.5 0.2 2.3 2 0 0 2 2 2 0 TrbC/VIRB2 family GAPT PF11770.8 ETO22540.1 - 1.6 8.6 11.5 0.52 10.2 6.3 2.5 2 1 0 2 2 2 0 GRB2-binding adapter (GAPT) DUF3149 PF11346.8 ETO22540.1 - 2.6 7.8 7.4 0.11 12.1 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3149) YajC PF02699.15 ETO22540.1 - 4.1 7.3 6.7 0.32 10.9 0.3 2.5 2 1 1 3 3 3 0 Preprotein translocase subunit AMP-binding PF00501.28 ETO22541.1 - 1.6e-24 86.3 1.6 2.1e-24 85.9 0.3 1.8 2 1 0 2 2 2 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO22541.1 - 0.0019 19.1 0.0 0.0075 17.2 0.0 2.0 1 1 1 2 2 2 1 AMP-binding enzyme C-terminal domain TM2 PF05154.16 ETO22542.1 - 0.057 13.8 3.9 0.14 12.5 3.9 1.7 1 0 0 1 1 1 0 TM2 domain RGS PF00615.19 ETO22543.1 - 1.4e-10 41.5 0.1 7.1e-10 39.2 0.1 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain rve_3 PF13683.6 ETO22543.1 - 0.0075 16.0 0.5 0.015 15.0 0.5 1.5 1 0 0 1 1 1 1 Integrase core domain NAAA-beta PF15508.6 ETO22544.1 - 1.6e-06 28.3 0.0 8.1e-06 26.0 0.0 2.1 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase SAE2 PF08573.10 ETO22545.1 - 4.7e-06 27.7 0.1 4.7e-06 27.7 0.1 4.0 2 2 1 3 3 3 2 DNA repair protein endonuclease SAE2/CtIP C-terminus ATP-synt_D PF01813.17 ETO22545.1 - 0.0044 16.9 0.5 0.0067 16.3 0.5 1.4 1 0 0 1 1 1 1 ATP synthase subunit D KMP11 PF03037.16 ETO22545.1 - 0.056 14.2 3.6 0.18 12.6 3.6 1.9 1 0 0 1 1 1 0 Kinetoplastid membrane protein 11 DUF4686 PF15742.5 ETO22545.1 - 0.087 12.0 25.0 0.11 11.6 24.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4686) Pept_tRNA_hydro PF01195.19 ETO22547.1 - 2.8e-18 66.4 0.1 3.5e-18 66.2 0.1 1.1 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase WWE PF02825.20 ETO22548.1 - 0.0025 18.4 0.9 0.019 15.6 0.9 2.6 1 0 0 1 1 1 1 WWE domain zf-CCCH PF00642.24 ETO22548.1 - 0.0041 17.0 1.6 0.0041 17.0 1.6 4.9 5 0 0 5 5 5 3 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3H1 PF10650.9 ETO22548.1 - 0.78 9.5 3.3 19 5.1 0.6 3.2 2 0 0 2 2 2 0 Putative zinc-finger domain Ribosomal_L1 PF00687.21 ETO22549.1 - 2e-10 40.8 1.1 3e-10 40.2 1.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family DUF5042 PF16445.5 ETO22549.1 - 0.16 10.3 0.0 0.21 9.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5042) Mit_ribos_Mrp51 PF11709.8 ETO22550.1 - 0.011 15.3 3.2 0.014 15.0 1.6 1.7 2 0 0 2 2 2 0 Mitochondrial ribosomal protein subunit Exonuc_VII_L PF02601.15 ETO22550.1 - 0.036 13.6 1.7 0.058 13.0 1.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit PSII_Pbs27 PF13326.6 ETO22550.1 - 0.043 14.1 3.9 0.089 13.1 3.9 1.5 1 0 0 1 1 1 0 Photosystem II Pbs27 OmpH PF03938.14 ETO22550.1 - 0.067 13.5 13.3 0.14 12.5 13.3 1.5 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) CemA PF03040.14 ETO22550.1 - 0.082 12.8 4.3 0.14 12.0 4.3 1.4 1 0 0 1 1 1 0 CemA family LMBR1 PF04791.16 ETO22550.1 - 0.11 11.4 3.0 0.1 11.5 3.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3348 PF11828.8 ETO22550.1 - 0.37 10.4 2.6 0.55 9.9 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3348) UvrD-helicase PF00580.21 ETO22550.1 - 0.54 9.7 10.0 0.33 10.4 7.2 1.8 2 0 0 2 2 2 0 UvrD/REP helicase N-terminal domain Sec5 PF15469.6 ETO22550.1 - 0.68 9.7 14.7 0.34 10.7 7.7 2.6 2 1 1 3 3 3 0 Exocyst complex component Sec5 APG6_N PF17675.1 ETO22550.1 - 0.88 10.1 15.4 0.83 10.2 13.5 1.9 2 0 0 2 2 2 0 Apg6 coiled-coil region POP1 PF06978.11 ETO22550.1 - 1.1 9.2 9.3 0.46 10.5 7.2 1.5 2 0 0 2 2 2 0 Ribonucleases P/MRP protein subunit POP1 HSP70 PF00012.20 ETO22550.1 - 1.7 6.8 11.4 2.9 6.0 11.4 1.3 1 0 0 1 1 1 0 Hsp70 protein Mst1_SARAH PF11629.8 ETO22550.1 - 5.5 7.2 10.1 6.6 6.9 0.5 2.5 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 DUF4473 PF14747.6 ETO22550.1 - 8.7 7.0 11.4 1.9 9.1 7.7 1.9 2 0 0 2 2 1 0 Domain of unknown function (DUF4473) Peptidase_M9_N PF08453.10 ETO22551.1 - 0.16 11.7 1.7 0.26 11.0 0.1 1.9 2 0 0 2 2 2 0 Peptidase family M9 N-terminal DUF4633 PF15464.6 ETO22552.1 - 0.085 13.0 0.3 0.18 12.0 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4633) M20_dimer PF07687.14 ETO22553.1 - 2.8e-06 27.2 0.0 4.2e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase dimerisation domain Peptidase_M20 PF01546.28 ETO22553.1 - 0.0001 22.1 0.0 0.00011 22.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 DAO_C PF16901.5 ETO22554.1 - 1e-31 109.4 0.1 2.2e-31 108.4 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase G10 PF01125.17 ETO22554.1 - 0.037 13.8 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 G10 protein Dynein_light PF01221.18 ETO22554.1 - 0.53 10.6 3.1 2.8 8.3 0.0 2.9 3 0 0 3 3 3 0 Dynein light chain type 1 Spc42p PF11544.8 ETO22555.1 - 0.031 14.3 1.8 0.071 13.1 1.8 1.6 1 0 0 1 1 1 0 Spindle pole body component Spc42p Phage_GP20 PF06810.11 ETO22555.1 - 0.038 13.8 0.6 0.058 13.2 0.6 1.3 1 0 0 1 1 1 0 Phage minor structural protein GP20 UEV PF05743.13 ETO22555.1 - 0.053 13.4 0.0 0.13 12.1 0.0 1.6 1 0 0 1 1 1 0 UEV domain PKcGMP_CC PF16808.5 ETO22555.1 - 0.059 13.2 0.9 0.059 13.2 0.9 1.9 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Occludin_ELL PF07303.13 ETO22555.1 - 0.083 13.6 1.9 0.2 12.4 1.9 1.6 1 1 0 1 1 1 0 Occludin homology domain PH PF00169.29 ETO22556.1 - 3.8e-15 56.3 0.8 1.3e-14 54.6 0.8 1.9 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO22556.1 - 3.1e-08 33.8 0.4 9.6e-08 32.2 0.2 2.0 2 0 0 2 2 1 1 Pleckstrin homology domain PH_6 PF15406.6 ETO22556.1 - 0.00099 19.4 0.0 0.0028 17.9 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO22556.1 - 0.0016 18.8 1.8 0.0016 18.8 1.8 3.1 2 2 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 ETO22556.1 - 0.0098 16.2 0.1 0.028 14.8 0.1 1.8 1 0 0 1 1 1 1 Plant pleckstrin homology-like region Mcp5_PH PF12814.7 ETO22556.1 - 0.012 15.7 0.2 0.035 14.2 0.2 1.8 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology HAUS-augmin3 PF14932.6 ETO22556.1 - 0.054 13.1 8.6 0.1 12.2 8.6 1.4 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 Helo_like_N PF17111.5 ETO22556.1 - 0.07 12.5 7.1 0.11 11.9 6.2 1.7 1 1 0 1 1 1 0 Fungal N-terminal domain of STAND proteins MIP-T3_C PF17749.1 ETO22556.1 - 0.089 12.8 14.6 0.22 11.5 14.6 1.6 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region DUF5089 PF17002.5 ETO22556.1 - 0.096 12.5 18.9 0.12 12.3 17.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF5089) HAUS5 PF14817.6 ETO22556.1 - 0.11 11.2 9.1 0.17 10.6 9.1 1.2 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 FemAB_like PF04339.12 ETO22556.1 - 0.15 11.2 3.1 0.27 10.3 3.1 1.4 1 0 0 1 1 1 0 Peptidogalycan biosysnthesis/recognition TMPIT PF07851.13 ETO22556.1 - 0.26 10.5 6.2 0.46 9.7 6.2 1.4 1 0 0 1 1 1 0 TMPIT-like protein FAM176 PF14851.6 ETO22556.1 - 1 9.0 9.5 2.2 8.0 9.5 1.6 1 0 0 1 1 1 0 FAM176 family FOXP-CC PF16159.5 ETO22556.1 - 1.1 10.0 6.3 3 8.5 1.5 2.5 1 1 1 2 2 2 0 FOXP coiled-coil domain Transglut_prok PF09017.10 ETO22556.1 - 1.9 7.8 6.8 3.5 6.9 6.8 1.4 1 0 0 1 1 1 0 Microbial transglutaminase FapA PF03961.13 ETO22556.1 - 2.1 6.9 12.2 0.17 10.5 7.7 1.5 2 0 0 2 2 2 0 Flagellar Assembly Protein A Cep57_CLD_2 PF14197.6 ETO22556.1 - 2.4 8.3 11.9 12 6.1 4.9 2.5 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 PA26 PF04636.13 ETO22556.1 - 2.5 6.9 11.4 4.5 6.1 11.4 1.4 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 ETO22556.1 - 3.6 6.2 6.4 6 5.5 6.4 1.4 1 0 0 1 1 1 0 Presenilin DUF2015 PF09435.10 ETO22558.1 - 0.053 13.4 0.0 0.098 12.5 0.0 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) Maf PF02545.14 ETO22559.1 - 1.2e-55 187.8 0.0 1.4e-55 187.6 0.0 1.0 1 0 0 1 1 1 1 Maf-like protein Aldedh PF00171.22 ETO22561.1 - 4.6e-11 41.9 2.5 8.2e-05 21.3 0.0 3.1 3 0 0 3 3 3 3 Aldehyde dehydrogenase family DEAD PF00270.29 ETO22562.1 - 5.7e-51 172.8 0.0 1.1e-50 171.8 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO22562.1 - 3.1e-32 111.2 0.0 1.6e-30 105.7 0.0 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO22562.1 - 0.0054 16.8 0.0 0.024 14.6 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ETO22562.1 - 0.05 12.4 0.0 2.2 7.0 0.0 2.7 3 0 0 3 3 3 0 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 Vps39_2 PF10367.9 ETO22563.1 - 1.5e-17 64.0 0.7 4e-17 62.6 0.2 1.9 2 0 0 2 2 2 1 Vacuolar sorting protein 39 domain 2 Sulfatase PF00884.23 ETO22564.1 - 7.6e-23 81.4 1.1 1.2e-22 80.7 1.1 1.3 1 0 0 1 1 1 1 Sulfatase ATG16 PF08614.11 ETO22565.1 - 0.00076 19.8 4.2 0.00097 19.4 4.2 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Stn1 PF10451.9 ETO22565.1 - 0.0015 17.5 0.9 0.0016 17.4 0.9 1.2 1 0 0 1 1 1 1 Telomere regulation protein Stn1 CAP_GLY PF01302.25 ETO22565.1 - 0.064 13.3 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 CAP-Gly domain Cnn_1N PF07989.11 ETO22565.1 - 0.22 11.7 5.2 0.44 10.7 5.2 1.5 1 0 0 1 1 1 0 Centrosomin N-terminal motif 1 bZIP_2 PF07716.15 ETO22565.1 - 0.27 11.3 5.2 0.56 10.3 5.2 1.5 1 0 0 1 1 1 0 Basic region leucine zipper CENP-H PF05837.12 ETO22565.1 - 0.38 11.2 6.8 0.19 12.2 4.4 1.7 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF1664 PF07889.12 ETO22565.1 - 0.47 10.5 6.5 2.9 8.0 2.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) THOC7 PF05615.13 ETO22565.1 - 1.9 8.7 8.7 6.4 7.1 8.7 1.8 1 1 0 1 1 1 0 Tho complex subunit 7 YabA PF06156.13 ETO22565.1 - 4.8 7.9 7.7 4.3 8.0 4.4 2.0 1 1 1 2 2 2 0 Initiation control protein YabA DUF4746 PF15928.5 ETO22566.1 - 0.1 12.0 4.3 0.13 11.7 4.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PP2C PF00481.21 ETO22567.1 - 0.071 12.7 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 Protein phosphatase 2C Gemini_mov PF01708.16 ETO22568.1 - 0.23 11.3 1.8 0.3 10.9 0.2 2.0 2 0 0 2 2 2 0 Geminivirus putative movement protein DUF4728 PF15860.5 ETO22568.1 - 6.8 7.4 10.8 13 6.5 3.2 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4728) mTERF PF02536.14 ETO22569.1 - 1.1e-06 27.8 3.1 1.9e-06 27.1 3.1 1.3 1 0 0 1 1 1 1 mTERF CDC45 PF02724.14 ETO22570.1 - 0.056 11.7 17.2 0.061 11.6 17.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO22570.1 - 0.2 9.8 19.6 0.2 9.8 19.6 1.0 1 0 0 1 1 1 0 Nop14-like family RR_TM4-6 PF06459.12 ETO22570.1 - 0.94 9.2 11.2 1 9.2 11.2 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DNA_pol_phi PF04931.13 ETO22570.1 - 1.5 6.9 19.0 1.6 6.7 19.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF1115 PF06544.12 ETO22570.1 - 3.3 7.8 9.4 4.6 7.3 9.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) Pkinase PF00069.25 ETO22571.1 - 0.0014 18.1 0.0 0.0024 17.3 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain 2OG-FeII_Oxy PF03171.20 ETO22571.1 - 0.11 13.0 0.0 0.25 11.9 0.0 1.7 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily tRNA-synt_1d PF00750.19 ETO22572.1 - 8.4e-17 61.1 0.0 1.2e-16 60.6 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (R) Arg_tRNA_synt_N PF03485.16 ETO22572.1 - 4.4e-05 24.0 0.0 8.9e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Arginyl tRNA synthetase N terminal domain tRNA_bind PF01588.20 ETO22572.1 - 0.0011 19.1 0.0 0.002 18.2 0.0 1.5 1 0 0 1 1 1 1 Putative tRNA binding domain DUF5639 PF18690.1 ETO22572.1 - 0.096 12.9 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5639) DUF5427 PF10310.9 ETO22575.1 - 0.19 10.7 10.1 0.22 10.4 10.1 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) Mito_carr PF00153.27 ETO22576.1 - 1.2e-24 86.0 0.1 5e-16 58.4 0.0 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein HAMP PF00672.25 ETO22576.1 - 0.05 14.0 0.0 0.1 13.0 0.0 1.5 1 0 0 1 1 1 0 HAMP domain FAM60A PF15396.6 ETO22577.1 - 0.097 12.7 9.3 0.11 12.5 9.3 1.1 1 0 0 1 1 1 0 Protein Family FAM60A AbLIM_anchor PF16182.5 ETO22577.1 - 0.1 12.4 6.9 0.12 12.2 6.9 1.0 1 0 0 1 1 1 0 Putative adherens-junction anchoring region of AbLIM Spt20 PF12090.8 ETO22577.1 - 0.26 10.9 16.3 0.31 10.6 16.3 1.1 1 0 0 1 1 1 0 Spt20 family MCM_bind PF09739.9 ETO22577.1 - 0.95 7.8 15.2 1.2 7.5 15.2 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Apis_Csd PF11671.8 ETO22577.1 - 0.99 9.4 16.9 1.2 9.1 16.9 1.3 1 0 0 1 1 1 0 Complementary sex determiner protein Sec62 PF03839.16 ETO22577.1 - 1 8.8 12.0 1.2 8.6 12.0 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Gti1_Pac2 PF09729.9 ETO22577.1 - 1.7 8.7 12.5 1.9 8.5 12.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family SLC12 PF03522.15 ETO22577.1 - 1.7 7.6 12.3 1.9 7.4 12.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Folliculin PF11704.8 ETO22577.1 - 2.9 7.7 7.7 3.8 7.4 7.7 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport NPR3 PF03666.13 ETO22577.1 - 4.4 6.0 16.8 5 5.8 16.8 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Neur_chan_memb PF02932.16 ETO22577.1 - 6.4 6.8 7.4 7.4 6.5 7.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Pannexin_like PF12534.8 ETO22577.1 - 7.5 5.5 6.9 8.7 5.3 6.9 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 CLN3 PF02487.17 ETO22577.1 - 8.6 5.3 7.7 10 5.0 7.7 1.0 1 0 0 1 1 1 0 CLN3 protein ALMT PF11744.8 ETO22577.1 - 9.2 5.0 10.4 10 4.8 10.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter adh_short PF00106.25 ETO22578.1 - 9.1e-11 41.6 0.1 1.2e-10 41.1 0.1 1.2 1 0 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 ETO22578.1 - 0.00052 19.6 0.2 0.0021 17.5 0.2 2.0 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ETO22578.1 - 0.022 14.7 0.0 0.037 13.9 0.0 1.4 1 0 0 1 1 1 0 KR domain DUF806 PF05657.11 ETO22578.1 - 0.12 12.9 0.0 1 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF806) Serglycin PF04360.12 ETO22579.1 - 0.01 15.8 0.4 0.01 15.8 0.4 2.1 3 0 0 3 3 3 0 Serglycin Secretin_N_2 PF07655.13 ETO22579.1 - 0.017 15.7 35.5 0.32 11.6 12.7 3.5 3 0 0 3 3 3 0 Secretin N-terminal domain Apis_Csd PF11671.8 ETO22579.1 - 0.18 11.8 31.1 0.083 12.9 9.8 2.5 2 0 0 2 2 2 0 Complementary sex determiner protein Corazonin PF17308.2 ETO22579.1 - 5.4 7.4 27.6 8.5 6.8 10.9 3.0 2 0 0 2 2 2 0 Pro-corazonin Methyltransf_12 PF08242.12 ETO22579.1 - 7.8 7.3 13.0 6.4 7.6 1.7 3.1 3 0 0 3 3 3 0 Methyltransferase domain Ion_trans PF00520.31 ETO22580.1 - 7.1e-13 48.3 14.8 8e-12 44.9 8.2 2.1 2 0 0 2 2 2 2 Ion transport protein DUF543 PF04418.12 ETO22580.1 - 0.042 13.8 0.1 0.12 12.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF543) Goodbye PF17109.5 ETO22580.1 - 0.12 12.8 0.0 0.26 11.7 0.0 1.5 2 0 0 2 2 2 0 fungal STAND N-terminal Goodbye domain DUF2207 PF09972.9 ETO22580.1 - 3.1 6.5 8.7 0.76 8.5 5.4 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) Ion_trans PF00520.31 ETO22581.1 - 8.9e-06 25.1 10.4 8.9e-06 25.1 10.4 2.5 2 1 0 2 2 2 1 Ion transport protein EF-hand_7 PF13499.6 ETO22581.1 - 0.08 13.4 0.1 0.17 12.3 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair YajC PF02699.15 ETO22583.1 - 0.26 11.2 6.4 4 7.4 1.5 2.8 3 0 0 3 3 3 0 Preprotein translocase subunit YMF19 PF02326.15 ETO22583.1 - 1.1 10.1 8.2 1.9 9.3 0.6 3.5 4 0 0 4 4 4 0 Plant ATP synthase F0 NAC PF01849.18 ETO22584.1 - 9.1e-12 44.8 0.1 2.1e-11 43.6 0.2 1.6 2 0 0 2 2 2 1 NAC domain TIP120 PF08623.10 ETO22584.1 - 0.00011 22.1 0.4 0.00011 22.0 0.4 1.1 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) Zf_RING PF16744.5 ETO22587.1 - 0.001 19.2 7.3 0.0015 18.6 6.2 1.9 2 0 0 2 2 2 1 KIAA1045 RING finger PHD PF00628.29 ETO22587.1 - 0.0083 16.0 8.0 0.0083 16.0 8.0 2.3 2 1 0 2 2 2 1 PHD-finger C1_2 PF03107.16 ETO22587.1 - 0.014 15.7 7.0 0.016 15.5 5.1 2.1 2 0 0 2 2 2 0 C1 domain zf-HC5HC2H PF13771.6 ETO22587.1 - 0.026 14.8 8.0 0.071 13.4 3.9 2.5 2 0 0 2 2 2 0 PHD-like zinc-binding domain zf-RING_2 PF13639.6 ETO22587.1 - 0.057 13.8 8.7 0.19 12.1 8.7 2.0 1 1 0 1 1 1 0 Ring finger domain SNARE PF05739.19 ETO22587.1 - 0.068 13.2 1.4 0.068 13.2 1.4 1.7 2 0 0 2 2 2 0 SNARE domain BAH PF01426.18 ETO22587.1 - 0.088 12.7 0.5 0.19 11.6 0.5 1.6 1 1 0 1 1 1 0 BAH domain Peptidase_A4 PF01828.17 ETO22589.1 - 1e-08 34.9 6.6 1.6e-08 34.3 6.6 1.3 1 1 0 1 1 1 1 Peptidase A4 family Neur_chan_LBD PF02931.23 ETO22591.1 - 0.0066 15.9 0.1 0.0085 15.6 0.1 1.1 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel ligand binding domain cobW PF02492.19 ETO22592.1 - 3.1e-27 95.3 1.9 7.4e-13 48.5 0.1 2.7 1 1 1 2 2 2 2 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ETO22592.1 - 2.6e-24 85.0 0.0 4.4e-24 84.2 0.0 1.4 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain PUB PF09409.10 ETO22594.1 - 6.4e-07 29.2 0.1 1.2e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 PUB domain FAM117 PF15388.6 ETO22595.1 - 0.1 12.0 3.2 0.18 11.2 3.2 1.4 1 0 0 1 1 1 0 Protein Family FAM117 CARM1 PF11531.8 ETO22596.1 - 0.0028 17.8 1.4 0.0071 16.5 1.4 1.7 1 0 0 1 1 1 1 Coactivator-associated arginine methyltransferase 1 N terminal SRP54_N PF02881.19 ETO22596.1 - 0.016 15.4 0.4 0.1 12.9 0.2 2.6 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain Get5_C PF18514.1 ETO22596.1 - 0.066 12.9 0.0 0.23 11.2 0.0 1.9 1 0 0 1 1 1 0 Get5 C-terminal domain VPS13_C PF16909.5 ETO22598.1 - 9.2e-29 100.5 6.5 5.6e-26 91.4 0.5 3.6 3 0 0 3 3 3 2 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 ETO22598.1 - 1.2e-17 64.2 3.0 2.2e-09 37.1 0.1 4.8 3 2 0 3 3 3 3 SHR-binding domain of vacuolar-sorting associated protein 13 ATG_C PF09333.11 ETO22598.1 - 1.8e-07 31.4 0.0 4.5e-07 30.1 0.0 1.7 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain DUF2326 PF10088.9 ETO22598.1 - 0.028 14.2 1.4 9.1 6.0 0.1 3.8 3 0 0 3 3 3 0 Uncharacterised protein conserved in bacteria (DUF2326) Aa_trans PF01490.18 ETO22599.1 - 2.4e-34 118.8 28.9 4.3e-34 117.9 28.9 1.4 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein Pectate_lyase_3 PF12708.7 ETO22600.1 - 1.3e-07 31.7 19.3 1.6e-07 31.4 7.8 3.4 2 1 0 2 2 2 2 Pectate lyase superfamily protein DUF948 PF06103.11 ETO22601.1 - 4.3e-06 26.9 4.0 9.1e-06 25.9 4.0 1.5 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 ETO22601.1 - 0.00022 21.2 5.8 0.00034 20.6 5.8 1.3 1 0 0 1 1 1 1 Laminin Domain II MCPsignal PF00015.21 ETO22601.1 - 0.0012 18.7 8.8 0.0018 18.1 8.8 1.2 1 0 0 1 1 1 1 Methyl-accepting chemotaxis protein (MCP) signalling domain CorA PF01544.18 ETO22601.1 - 0.0012 18.3 1.4 0.079 12.3 0.1 2.2 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein DUF812 PF05667.11 ETO22601.1 - 0.0016 17.4 2.8 0.0016 17.4 2.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF812) RmuC PF02646.16 ETO22601.1 - 0.0021 17.2 1.3 0.0032 16.7 1.3 1.3 1 0 0 1 1 1 1 RmuC family DUF1664 PF07889.12 ETO22601.1 - 0.0028 17.7 2.1 0.0028 17.7 2.1 1.6 2 0 0 2 2 1 1 Protein of unknown function (DUF1664) LXG PF04740.12 ETO22601.1 - 0.003 17.3 3.6 0.0041 16.9 3.6 1.2 1 0 0 1 1 1 1 LXG domain of WXG superfamily Cauli_AT PF03233.13 ETO22601.1 - 0.0079 16.1 0.4 0.011 15.7 0.4 1.3 1 0 0 1 1 1 1 Aphid transmission protein SesA PF17107.5 ETO22601.1 - 0.013 15.7 2.0 0.03 14.5 1.9 1.5 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases ApoLp-III PF07464.11 ETO22601.1 - 0.014 15.5 5.2 0.024 14.7 5.2 1.4 1 0 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) WXG100 PF06013.12 ETO22601.1 - 0.015 15.5 1.1 0.72 10.1 0.3 2.3 1 1 0 1 1 1 0 Proteins of 100 residues with WXG RNA_pol_3_Rpc31 PF11705.8 ETO22601.1 - 0.017 15.4 4.9 0.017 15.4 4.9 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TMP_2 PF06791.13 ETO22601.1 - 0.017 14.8 1.6 0.026 14.2 1.6 1.2 1 0 0 1 1 1 0 Prophage tail length tape measure protein CENP-F_leu_zip PF10473.9 ETO22601.1 - 0.026 14.5 6.7 0.026 14.5 6.7 1.9 3 0 0 3 3 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Sec34 PF04136.15 ETO22601.1 - 0.026 14.4 2.6 0.047 13.6 2.6 1.3 1 0 0 1 1 1 0 Sec34-like family DUF848 PF05852.11 ETO22601.1 - 0.03 14.5 4.8 0.041 14.0 4.8 1.2 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) UPF0242 PF06785.11 ETO22601.1 - 0.031 14.4 0.5 0.041 14.0 0.5 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3671 PF12420.8 ETO22601.1 - 0.035 14.2 0.5 0.054 13.6 0.5 1.5 1 1 0 1 1 1 0 Protein of unknown function ApoO PF09769.9 ETO22601.1 - 0.038 14.0 0.6 0.53 10.3 0.2 2.3 2 0 0 2 2 2 0 Apolipoprotein O YtxH PF12732.7 ETO22601.1 - 0.04 14.5 12.5 2.8 8.5 12.6 2.5 1 1 0 1 1 1 0 YtxH-like protein TMPIT PF07851.13 ETO22601.1 - 0.041 13.1 1.2 0.069 12.4 1.2 1.3 1 0 0 1 1 1 0 TMPIT-like protein BROMI PF14961.6 ETO22601.1 - 0.043 11.2 1.0 0.18 9.2 0.0 1.8 1 1 1 2 2 2 0 Broad-minded protein TMEM214 PF10151.9 ETO22601.1 - 0.045 12.2 1.0 0.18 10.2 0.9 1.7 1 1 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator Med21 PF11221.8 ETO22601.1 - 0.048 13.9 1.7 0.066 13.5 1.7 1.4 1 0 0 1 1 1 0 Subunit 21 of Mediator complex DASH_Duo1 PF08651.10 ETO22601.1 - 0.055 13.2 1.1 1.1 9.1 0.6 2.3 1 1 2 3 3 3 0 DASH complex subunit Duo1 Laminin_I PF06008.14 ETO22601.1 - 0.066 12.9 3.5 0.093 12.4 3.5 1.2 1 0 0 1 1 1 0 Laminin Domain I Chlorosome_CsmC PF11098.8 ETO22601.1 - 0.067 13.2 3.2 0.11 12.5 3.2 1.4 1 0 0 1 1 1 0 Chlorosome envelope protein C Plk4_PB2 PF18409.1 ETO22601.1 - 0.07 13.8 1.6 0.57 10.9 1.2 2.1 1 1 1 2 2 2 0 Polo-like Kinase 4 Polo Box 2 DUF2048 PF09752.9 ETO22601.1 - 0.071 12.2 1.7 0.087 11.9 1.7 1.0 1 0 0 1 1 1 0 Abhydrolase domain containing 18 DUF1054 PF06335.12 ETO22601.1 - 0.073 13.0 0.8 0.1 12.5 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1054) DUF16 PF01519.16 ETO22601.1 - 0.075 13.5 1.9 0.14 12.6 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF16 Phage_HK97_TLTM PF06120.11 ETO22601.1 - 0.092 11.9 3.7 0.13 11.4 3.7 1.2 1 0 0 1 1 1 0 Tail length tape measure protein Fib_alpha PF08702.10 ETO22601.1 - 0.092 12.9 1.3 0.18 12.0 1.3 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family ISG65-75 PF11727.8 ETO22601.1 - 0.1 11.8 6.0 0.16 11.2 6.0 1.3 1 0 0 1 1 1 0 Invariant surface glycoprotein Ferritin PF00210.24 ETO22601.1 - 0.1 12.5 3.1 0.16 11.9 3.1 1.4 1 0 0 1 1 1 0 Ferritin-like domain Zw10 PF06248.13 ETO22601.1 - 0.11 11.0 4.9 0.15 10.6 4.9 1.2 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 Ribophorin_II PF05817.14 ETO22601.1 - 0.11 11.0 2.0 0.15 10.5 2.0 1.2 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit Ribophorin II DUF1129 PF06570.11 ETO22601.1 - 0.12 11.8 1.4 0.19 11.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Syntaxin-6_N PF09177.11 ETO22601.1 - 0.12 12.9 9.0 0.1 13.2 6.4 2.1 2 1 0 2 2 1 0 Syntaxin 6, N-terminal FlgN PF05130.12 ETO22601.1 - 0.13 12.8 1.3 0.2 12.2 1.3 1.3 1 0 0 1 1 1 0 FlgN protein FlaC_arch PF05377.11 ETO22601.1 - 0.13 12.6 9.0 0.24 11.8 5.0 2.4 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) DUF1484 PF07363.11 ETO22601.1 - 0.14 13.2 0.3 0.24 12.4 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1484) DUF2703 PF10865.8 ETO22601.1 - 0.14 12.3 2.1 3.8 7.7 0.7 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF2703) VSG_B PF13206.6 ETO22601.1 - 0.16 11.2 2.9 0.21 10.8 2.9 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain AATF-Che1 PF13339.6 ETO22601.1 - 0.16 12.6 1.5 0.43 11.3 1.4 1.7 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor DUF2897 PF11446.8 ETO22601.1 - 0.17 11.8 0.9 0.27 11.2 0.0 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF2897) DUF4337 PF14235.6 ETO22601.1 - 0.22 11.6 4.5 0.43 10.7 4.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) T2SSF PF00482.23 ETO22601.1 - 0.22 11.5 0.3 14 5.6 0.0 2.2 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein F Med9 PF07544.13 ETO22601.1 - 0.27 11.3 2.0 1.3 9.1 0.6 2.2 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DNA_ligase_A_N PF04675.14 ETO22601.1 - 0.35 11.2 3.7 0.78 10.0 3.7 1.6 1 1 0 1 1 1 0 DNA ligase N terminus COG2 PF06148.11 ETO22601.1 - 0.41 10.7 4.7 0.9 9.6 4.7 1.6 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Seryl_tRNA_N PF02403.22 ETO22601.1 - 0.52 10.6 6.4 0.7 10.1 4.7 1.8 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain DUF4330 PF14221.6 ETO22601.1 - 0.72 10.1 8.0 1.2 9.3 8.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) DUF2203 PF09969.9 ETO22601.1 - 0.82 10.4 4.4 1.1 10.0 0.4 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) APG6_N PF17675.1 ETO22601.1 - 0.82 10.2 8.0 1.1 9.8 8.0 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region DUF883 PF05957.13 ETO22601.1 - 0.83 10.3 6.0 2.7 8.6 4.9 2.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) TelA PF05816.11 ETO22601.1 - 0.91 8.5 9.8 0.24 10.4 6.4 1.6 2 0 0 2 2 2 0 Toxic anion resistance protein (TelA) DUF241 PF03087.14 ETO22601.1 - 1.3 8.9 4.9 0.8 9.5 3.0 1.5 1 1 1 2 2 2 0 Arabidopsis protein of unknown function Prefoldin_2 PF01920.20 ETO22601.1 - 1.3 9.0 8.4 10 6.1 8.4 2.2 1 1 0 1 1 1 0 Prefoldin subunit eIF3_N PF09440.10 ETO22601.1 - 1.6 9.1 6.6 3 8.3 6.4 1.5 1 1 0 1 1 1 0 eIF3 subunit 6 N terminal domain Prominin PF05478.11 ETO22601.1 - 1.7 6.5 8.2 0.12 10.3 2.8 1.7 1 1 1 2 2 2 0 Prominin DUF2524 PF10732.9 ETO22601.1 - 1.9 8.8 5.1 5.5 7.4 2.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2524) Rx_N PF18052.1 ETO22601.1 - 2.2 8.6 5.6 6.7 7.1 5.6 1.7 1 1 0 1 1 1 0 Rx N-terminal domain DUF4446 PF14584.6 ETO22601.1 - 2.7 8.0 7.5 1.5 8.8 1.0 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) LUC7 PF03194.15 ETO22601.1 - 6.1 6.4 9.4 4.6 6.8 7.6 1.6 1 1 1 2 2 2 0 LUC7 N_terminus Arf PF00025.21 ETO22604.1 - 1.1e-51 174.8 0.0 1.7e-49 167.7 0.0 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETO22604.1 - 3e-09 36.5 0.1 2.9e-06 26.7 0.0 2.3 1 1 1 2 2 2 2 G-protein alpha subunit MMR_HSR1 PF01926.23 ETO22604.1 - 4.3e-08 33.2 0.0 7.3e-08 32.5 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ETO22604.1 - 1.4e-07 31.8 0.0 3e-07 30.7 0.0 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETO22604.1 - 4.3e-07 29.6 0.0 6.2e-07 29.0 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ETO22604.1 - 6.6e-07 29.1 0.0 9.2e-07 28.6 0.0 1.2 1 0 0 1 1 1 1 Ras family GTP_EFTU PF00009.27 ETO22604.1 - 0.0003 20.4 0.1 0.058 12.9 0.0 2.1 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO22604.1 - 0.0007 19.0 0.0 0.00096 18.6 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ETO22604.1 - 0.021 14.3 0.0 0.035 13.6 0.0 1.5 1 1 0 1 1 1 0 Ferrous iron transport protein B PduV-EutP PF10662.9 ETO22604.1 - 0.085 12.6 0.0 0.51 10.1 0.0 2.0 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation AAA_22 PF13401.6 ETO22604.1 - 0.1 12.9 0.1 1.4 9.2 0.1 2.1 1 1 0 1 1 1 0 AAA domain Imm43 PF15570.6 ETO22604.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 43 Bap31 PF05529.12 ETO22605.1 - 2.2 8.1 6.5 8.9 6.2 0.3 2.4 2 1 1 3 3 3 0 Bap31/Bap29 transmembrane region RabGAP-TBC PF00566.18 ETO22606.1 - 9e-07 28.8 0.4 9e-07 28.8 0.4 3.1 3 0 0 3 3 3 1 Rab-GTPase-TBC domain Ni_hydr_CYTB PF01292.20 ETO22606.1 - 0.084 12.5 0.2 0.12 12.0 0.2 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Folate_carrier PF01770.18 ETO22606.1 - 0.098 11.4 2.3 0.16 10.7 2.3 1.3 1 0 0 1 1 1 0 Reduced folate carrier Presenilin PF01080.17 ETO22606.1 - 0.43 9.3 3.4 0.61 8.8 3.4 1.2 1 0 0 1 1 1 0 Presenilin ORC_WH_C PF18137.1 ETO22606.1 - 0.73 9.9 0.0 0.73 9.9 0.0 2.3 1 1 0 2 2 2 0 Origin recognition complex winged helix C-terminal NPR3 PF03666.13 ETO22606.1 - 0.89 8.3 6.5 1.2 7.9 6.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Orf78 PF06024.12 ETO22606.1 - 1.1 9.6 15.0 12 6.3 16.3 2.1 2 0 0 2 2 2 0 Orf78 (ac78) PDDEXK_6 PF04720.12 ETO22606.1 - 4.6 7.1 5.4 6.7 6.6 5.4 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Pox_Ag35 PF03286.14 ETO22606.1 - 5.6 6.7 8.7 9.9 5.9 8.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4834 PF16118.5 ETO22606.1 - 9.5 7.3 8.7 20 6.2 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) PPR_2 PF13041.6 ETO22607.1 - 5.7e-08 32.8 6.0 0.0069 16.6 0.1 3.5 1 1 1 3 3 3 2 PPR repeat family PPR PF01535.20 ETO22607.1 - 1e-05 25.4 5.2 0.013 15.7 0.2 3.4 3 0 0 3 3 3 2 PPR repeat ATP13 PF12921.7 ETO22607.1 - 0.00015 21.6 0.4 0.25 11.2 0.1 3.2 1 1 2 3 3 3 2 Mitochondrial ATPase expression PPR_3 PF13812.6 ETO22607.1 - 0.0002 21.3 1.9 0.0039 17.2 0.1 3.1 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO22607.1 - 0.089 12.5 0.0 2.2 8.1 0.0 2.5 2 0 0 2 2 2 0 PPR repeat RSN1_TM PF13967.6 ETO22608.1 - 0.062 13.1 0.2 0.16 11.7 0.2 1.7 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport CotJB PF12652.7 ETO22609.1 - 0.018 15.2 0.9 7.5 6.8 0.0 2.8 3 0 0 3 3 3 0 CotJB protein PI-PLC-X PF00388.19 ETO22609.1 - 0.031 13.9 0.0 0.075 12.6 0.0 1.6 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain STALD PF18185.1 ETO22610.1 - 0.15 11.4 2.5 0.12 11.7 0.3 1.9 2 0 0 2 2 2 0 Sir2- and TIR-associating SLOG family Menin PF05053.13 ETO22610.1 - 1.8 6.8 19.2 2.2 6.5 19.2 1.2 1 0 0 1 1 1 0 Menin UreE_N PF02814.15 ETO22610.1 - 8 6.1 6.6 8 6.1 0.3 2.5 2 0 0 2 2 2 0 UreE urease accessory protein, N-terminal domain HEAT PF02985.22 ETO22611.1 - 1.7e-05 24.7 0.0 0.00018 21.5 0.0 2.3 2 0 0 2 2 2 1 HEAT repeat HEAT_2 PF13646.6 ETO22611.1 - 9.2e-05 22.8 0.0 0.0045 17.3 0.0 2.1 2 0 0 2 2 2 1 HEAT repeats HEAT_EZ PF13513.6 ETO22611.1 - 0.065 13.8 0.0 0.21 12.1 0.0 1.8 2 0 0 2 2 2 0 HEAT-like repeat Arm PF00514.23 ETO22611.1 - 0.066 13.3 0.0 0.21 11.7 0.0 1.9 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat CSRNP_N PF16019.5 ETO22613.1 - 0.0091 15.9 0.3 0.017 15.0 0.3 1.4 1 0 0 1 1 1 1 Cysteine/serine-rich nuclear protein N-terminus EMC3_TMCO1 PF01956.16 ETO22613.1 - 0.14 11.9 2.5 0.24 11.1 2.5 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like HECT PF00632.25 ETO22614.1 - 3.9e-55 187.5 0.0 4.1e-43 148.0 0.2 2.3 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.6 ETO22614.1 - 1.6e-06 28.3 0.1 4.1e-06 27.0 0.1 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3782 PF12644.7 ETO22614.1 - 0.12 12.5 0.0 0.39 10.9 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3782) Raco_middle PF17651.1 ETO22614.1 - 0.13 12.0 0.2 0.3 10.8 0.2 1.5 1 0 0 1 1 1 0 RACo middle region SPRY PF00622.28 ETO22615.1 - 3e-14 53.2 1.3 1.3e-13 51.1 0.2 2.7 3 0 0 3 3 3 1 SPRY domain zf-RanBP PF00641.18 ETO22615.1 - 8.5e-05 21.8 3.9 0.00024 20.4 3.9 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others RyR PF02026.16 ETO22615.1 - 0.068 13.4 0.3 0.5 10.6 0.1 2.5 2 0 0 2 2 2 0 RyR domain Vps36-NZF-N PF16988.5 ETO22615.1 - 1.2 8.6 6.6 5.2 6.5 6.6 2.2 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Tubulin_C PF03953.17 ETO22616.1 - 5.1e-29 101.0 0.0 8.3e-29 100.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO22616.1 - 1.5e-23 84.1 0.0 2.4e-23 83.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain tRNA-synt_1c_C PF03950.18 ETO22616.1 - 0.02 14.8 0.1 0.05 13.5 0.0 1.6 2 0 0 2 2 2 0 tRNA synthetases class I (E and Q), anti-codon binding domain Ion_trans_2 PF07885.16 ETO22617.1 - 1.3e-09 37.9 3.9 1.3e-09 37.9 3.9 2.3 2 0 0 2 2 2 1 Ion channel Rax2 PF12768.7 ETO22617.1 - 0.0018 17.8 0.5 0.63 9.5 0.0 2.1 2 0 0 2 2 2 2 Cortical protein marker for cell polarity Sigma_reg_N PF13800.6 ETO22617.1 - 0.031 14.5 1.1 0.031 14.5 1.1 2.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal DUF2976 PF11190.8 ETO22617.1 - 0.1 12.4 1.4 6.1 6.7 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2976) DUF3671 PF12420.8 ETO22617.1 - 0.17 11.9 9.0 0.11 12.5 6.6 1.9 2 1 0 2 2 2 0 Protein of unknown function HlyD_2 PF12700.7 ETO22617.1 - 1.3 7.7 3.1 2 7.1 3.1 1.2 1 0 0 1 1 1 0 HlyD family secretion protein BUD22 PF09073.10 ETO22618.1 - 6.7e-05 22.4 0.9 6.9e-05 22.4 0.9 1.0 1 0 0 1 1 1 1 BUD22 DUF1980 PF09323.10 ETO22618.1 - 0.00012 22.0 0.2 0.00018 21.5 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF1980) Acetyltransf_1 PF00583.25 ETO22618.1 - 0.0084 16.3 0.0 0.033 14.4 0.0 1.9 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Connexin PF00029.19 ETO22618.1 - 0.014 15.2 0.1 0.02 14.7 0.1 1.1 1 0 0 1 1 1 0 Connexin Pinin_SDK_memA PF04696.13 ETO22618.1 - 0.035 14.2 5.3 0.051 13.6 5.3 1.2 1 0 0 1 1 1 0 pinin/SDK/memA/ protein conserved region DUF4820 PF16091.5 ETO22618.1 - 0.06 12.7 2.6 0.081 12.3 2.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Afi1 PF07792.12 ETO22618.1 - 0.083 13.4 3.1 0.14 12.6 3.1 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CLN3 PF02487.17 ETO22618.1 - 0.11 11.5 0.2 0.15 11.0 0.2 1.1 1 0 0 1 1 1 0 CLN3 protein S-antigen PF05756.11 ETO22618.1 - 0.14 12.5 3.8 0.38 11.2 3.8 1.7 1 0 0 1 1 1 0 S-antigen protein LZ_Tnp_IS66 PF13007.7 ETO22618.1 - 0.32 11.8 4.4 0.51 11.2 4.4 1.3 1 0 0 1 1 1 0 Transposase C of IS166 homeodomain DUF4637 PF15470.6 ETO22618.1 - 1 9.1 7.3 1.5 8.5 7.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) tRNA_bind_2 PF13725.6 ETO22618.1 - 1 9.0 6.1 1.3 8.6 6.1 1.1 1 0 0 1 1 1 0 Possible tRNA binding domain Presenilin PF01080.17 ETO22618.1 - 4.4 6.0 5.5 6 5.5 5.5 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ETO22618.1 - 5.6 6.6 7.5 8.9 6.0 7.5 1.2 1 0 0 1 1 1 0 FAM176 family Sulfatase PF00884.23 ETO22619.1 - 3.4e-13 49.7 0.1 4.4e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ETO22619.1 - 0.00067 19.4 0.0 0.00082 19.1 0.0 1.3 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ETO22620.1 - 1.5e-14 54.1 0.3 1.8e-14 53.8 0.3 1.1 1 0 0 1 1 1 1 Sulfatase BAF1_ABF1 PF04684.13 ETO22621.1 - 0.0095 15.0 11.0 0.01 14.9 11.0 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor RskA PF10099.9 ETO22621.1 - 0.011 16.1 0.3 0.011 16.0 0.3 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Nrap PF03813.14 ETO22621.1 - 0.023 14.8 2.7 0.028 14.5 2.7 1.2 1 0 0 1 1 1 0 Nrap protein domain 1 DUF4148 PF13663.6 ETO22621.1 - 0.03 14.5 0.1 0.051 13.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) ETRAMP PF09716.10 ETO22621.1 - 0.37 10.9 6.0 0.12 12.5 2.6 1.8 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Zip PF02535.22 ETO22621.1 - 3.6 6.7 5.7 3.9 6.6 5.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Ni_hydr_CYTB PF01292.20 ETO22622.1 - 0.0069 16.0 0.2 0.012 15.2 0.2 1.4 1 0 0 1 1 1 1 Prokaryotic cytochrome b561 DUF2149 PF09919.9 ETO22622.1 - 0.056 13.7 1.1 0.097 12.9 0.3 1.8 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2149) DUF4834 PF16118.5 ETO22622.1 - 0.081 13.9 2.3 0.14 13.1 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ECSCR PF15820.5 ETO22622.1 - 0.09 12.6 0.1 0.09 12.6 0.1 2.3 2 1 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator DUF4746 PF15928.5 ETO22623.1 - 0.33 10.3 14.3 0.39 10.1 14.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF966 PF06136.13 ETO22623.1 - 0.82 9.3 12.3 0.93 9.2 12.3 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF966) CCSAP PF15748.5 ETO22623.1 - 1.2 9.3 15.8 1.4 9.0 15.8 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Spore_coat_CotO PF14153.6 ETO22623.1 - 1.2 9.0 18.3 1.7 8.6 18.3 1.2 1 0 0 1 1 1 0 Spore coat protein CotO Neur_chan_memb PF02932.16 ETO22623.1 - 2.2 8.3 5.4 2.7 8.0 5.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Smg8_Smg9 PF10220.9 ETO22623.1 - 2.7 6.2 12.9 3.3 5.9 12.9 1.1 1 0 0 1 1 1 0 Smg8_Smg9 XRN_M PF17846.1 ETO22623.1 - 4 6.3 9.6 4.5 6.1 9.6 1.2 1 0 0 1 1 1 0 Xrn1 helical domain RRN3 PF05327.11 ETO22623.1 - 4.4 5.7 8.1 5.3 5.5 8.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Presenilin PF01080.17 ETO22623.1 - 4.9 5.8 14.7 6.4 5.4 14.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO22623.1 - 5 5.3 16.1 6.1 5.0 16.1 1.1 1 0 0 1 1 1 0 CDC45-like protein SAPS PF04499.15 ETO22623.1 - 6.9 5.3 14.3 7.6 5.2 14.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SLC12 PF03522.15 ETO22623.1 - 9.6 5.1 12.9 9.5 5.1 12.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 HSP70 PF00012.20 ETO22624.1 - 1.1e-29 103.1 1.4 1.5e-29 102.7 1.4 1.4 1 0 0 1 1 1 1 Hsp70 protein Z1 PF10593.9 ETO22624.1 - 0.041 13.4 4.5 0.019 14.5 1.5 1.8 1 1 1 2 2 2 0 Z1 domain HSP70 PF00012.20 ETO22625.1 - 4e-12 45.1 0.1 5.6e-12 44.7 0.1 1.2 1 0 0 1 1 1 1 Hsp70 protein GCS PF03074.16 ETO22627.1 - 3.6e-106 355.6 0.0 4e-106 355.5 0.0 1.0 1 0 0 1 1 1 1 Glutamate-cysteine ligase PGA_cap PF09587.10 ETO22627.1 - 0.066 12.7 0.0 0.12 11.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap Sua5_yciO_yrdC PF01300.18 ETO22628.1 - 4.4e-47 159.9 0.0 1e-46 158.7 0.0 1.6 2 0 0 2 2 2 1 Telomere recombination SUA5 PF03481.13 ETO22628.1 - 5.5e-11 43.2 0.1 1.5e-10 41.7 0.1 1.7 1 0 0 1 1 1 1 Putative GTP-binding controlling metal-binding SL4P PF17618.2 ETO22629.1 - 0.034 14.2 0.3 0.34 11.0 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized Strongylid L4 protein CT47 PF15623.6 ETO22629.1 - 0.92 9.3 8.7 1.6 8.5 8.7 1.3 1 0 0 1 1 1 0 Cancer/testis gene family 47 DUF3769 PF12600.8 ETO22630.1 - 0.019 13.8 0.4 0.022 13.6 0.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3769) Dsl1_N PF11988.8 ETO22630.1 - 0.04 12.9 7.3 0.049 12.6 7.3 1.0 1 0 0 1 1 1 0 Retrograde transport protein Dsl1 N terminal GHD PF17834.1 ETO22633.1 - 2.7e-09 37.0 0.9 6e-09 35.8 0.1 2.0 2 0 0 2 2 2 1 Beta-sandwich domain in beta galactosidase Ricin_B_lectin PF00652.22 ETO22633.1 - 4.1e-05 23.8 0.1 0.0001 22.5 0.1 1.6 2 0 0 2 2 2 1 Ricin-type beta-trefoil lectin domain Striatin PF08232.12 ETO22634.1 - 3.5 8.2 10.0 1.2 9.7 4.2 2.3 2 0 0 2 2 2 0 Striatin family NPR3 PF03666.13 ETO22634.1 - 8 5.1 14.1 0.32 9.7 6.5 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 ETO22634.1 - 8.9 5.0 7.3 1 8.1 2.2 1.8 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 DUF3807 PF12720.7 ETO22634.1 - 9.6 6.4 14.9 1.4 9.1 7.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) TFIIA PF03153.13 ETO22635.1 - 0.21 11.5 32.0 0.55 10.2 32.0 1.7 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Androgen_recep PF02166.16 ETO22635.1 - 1.1 8.0 13.2 2.2 7.0 13.2 1.5 1 0 0 1 1 1 0 Androgen receptor Dala_Dala_lig_N PF01820.21 ETO22635.1 - 4.7 7.7 6.8 4.5 7.8 0.1 3.3 3 0 0 3 3 3 0 D-ala D-ala ligase N-terminus DUF3987 PF13148.6 ETO22635.1 - 8.9 5.2 9.1 2.2 7.2 3.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) TPR_19 PF14559.6 ETO22636.1 - 8e-09 35.9 1.8 7.5e-05 23.2 0.1 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22636.1 - 1.2e-06 28.8 2.8 0.00017 22.0 0.1 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO22636.1 - 2.9e-06 27.4 7.5 5.4e-06 26.5 2.1 2.8 1 1 2 3 3 3 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETO22636.1 - 3.2e-06 26.8 8.1 4e-05 23.4 0.3 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_18 PF13512.6 ETO22636.1 - 3.8e-05 23.8 3.3 5.2e-05 23.4 3.3 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22636.1 - 4e-05 23.5 2.2 0.0061 16.7 0.1 3.4 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22636.1 - 4.1e-05 24.0 0.1 0.035 14.9 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat YfiO PF13525.6 ETO22636.1 - 9.6e-05 22.2 3.3 0.00014 21.7 3.3 1.3 1 0 0 1 1 1 1 Outer membrane lipoprotein TPR_1 PF00515.28 ETO22636.1 - 0.00011 21.8 4.5 0.0016 18.2 0.7 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22636.1 - 0.00059 20.4 0.9 0.003 18.2 0.2 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO22636.1 - 0.00082 19.6 3.6 0.0018 18.5 1.4 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat RPN13_C PF16550.5 ETO22636.1 - 0.006 16.7 0.1 0.07 13.3 0.0 2.1 2 0 0 2 2 2 1 UCH-binding domain TPR_21 PF09976.9 ETO22636.1 - 0.022 14.5 0.9 0.033 13.9 0.9 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_7 PF13176.6 ETO22636.1 - 0.031 14.3 3.1 0.32 11.1 0.2 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22636.1 - 0.35 10.6 6.1 0.08 12.6 1.6 2.3 3 0 0 3 3 3 0 TPR repeat ANAPC3 PF12895.7 ETO22637.1 - 0.00023 21.3 0.2 0.001 19.3 0.2 2.2 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO22637.1 - 0.00035 21.0 0.1 0.0027 18.2 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat RET_CLD3 PF17812.1 ETO22637.1 - 0.0015 18.8 1.1 0.0051 17.1 0.4 2.2 1 1 1 2 2 2 1 RET Cadherin like domain 3 TPR_7 PF13176.6 ETO22637.1 - 0.011 15.8 0.1 0.49 10.5 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat DSPc PF00782.20 ETO22637.1 - 0.012 15.4 0.1 0.072 12.9 0.0 2.4 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain TPR_10 PF13374.6 ETO22637.1 - 0.019 14.8 0.5 3.1 7.8 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO22637.1 - 0.039 14.2 0.1 0.48 10.8 0.1 2.8 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22637.1 - 0.21 11.4 3.9 0.49 10.3 0.1 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat RPN6_N PF18055.1 ETO22637.1 - 0.54 10.6 4.8 1.7 9.0 0.4 2.7 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN6 N-terminal domain Pex14_N PF04695.13 ETO22640.1 - 2.5 8.7 8.5 12 6.5 0.1 2.7 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MitMem_reg PF13012.6 ETO22641.1 - 7.9e-37 126.1 0.0 1.2e-36 125.5 0.0 1.3 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ETO22641.1 - 1.1e-05 25.4 0.0 1.1e-05 25.4 0.0 2.4 2 1 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease RNA_pol_Rpc4 PF05132.14 ETO22641.1 - 0.00021 21.8 0.2 0.00027 21.4 0.2 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 Pex24p PF06398.11 ETO22641.1 - 0.038 13.0 0.9 0.049 12.6 0.9 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin CDC45 PF02724.14 ETO22641.1 - 0.063 11.6 11.7 0.077 11.3 11.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2201_N PF13203.6 ETO22641.1 - 0.32 10.6 4.0 0.47 10.0 4.0 1.2 1 0 0 1 1 1 0 Putative metallopeptidase domain SET PF00856.28 ETO22641.1 - 0.41 11.0 6.1 0.44 10.9 6.1 1.3 1 1 0 1 1 1 0 SET domain DUF913 PF06025.12 ETO22641.1 - 0.53 9.2 6.4 0.9 8.4 6.4 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CLN3 PF02487.17 ETO22641.1 - 1.6 7.7 5.6 2.8 6.9 5.6 1.4 1 0 0 1 1 1 0 CLN3 protein Afi1 PF07792.12 ETO22641.1 - 2.1 8.8 18.9 3.9 8.0 18.9 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Aminotran_1_2 PF00155.21 ETO22642.1 - 1.8e-58 198.5 0.0 1.9e-54 185.3 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II EF-hand_4 PF12763.7 ETO22643.1 - 0.054 13.5 0.4 0.072 13.0 0.4 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand CZB PF13682.6 ETO22643.1 - 0.1 13.1 1.4 16 6.1 0.0 2.4 2 1 0 2 2 2 0 Chemoreceptor zinc-binding domain DUF4512 PF14975.6 ETO22644.1 - 0.071 13.9 0.2 0.18 12.6 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) Toxin_17 PF08086.11 ETO22644.1 - 0.13 12.6 1.4 0.24 11.7 0.2 2.0 2 0 0 2 2 2 0 Ergtoxin family Peptidase_C78 PF07910.13 ETO22645.1 - 8.4e-09 35.2 0.1 1.6e-05 24.5 0.0 2.3 2 0 0 2 2 2 2 Peptidase family C78 Peptidase_C54 PF03416.19 ETO22645.1 - 0.005 16.3 1.7 0.022 14.2 0.4 2.4 1 1 2 3 3 3 1 Peptidase family C54 IMUP PF15761.5 ETO22645.1 - 0.13 13.0 5.2 0.2 12.3 5.2 1.3 1 0 0 1 1 1 0 Immortalisation up-regulated protein BB_PF PF18063.1 ETO22645.1 - 0.26 10.8 3.8 7.7 6.0 0.1 2.2 2 0 0 2 2 2 0 Beta barrel Pore-forming domain Synaptobrevin PF00957.21 ETO22646.1 - 7.6e-14 51.3 2.4 7.6e-14 51.3 2.4 1.7 2 0 0 2 2 2 1 Synaptobrevin Longin PF13774.6 ETO22646.1 - 1.4e-05 25.0 0.0 2.5e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Regulated-SNARE-like domain Spc7 PF08317.11 ETO22646.1 - 0.0058 15.6 0.4 0.0058 15.6 0.4 1.3 2 0 0 2 2 2 1 Spc7 kinetochore protein COG2 PF06148.11 ETO22646.1 - 0.0094 16.0 1.2 0.0094 16.0 1.2 1.6 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 Rsd_AlgQ PF04353.13 ETO22646.1 - 0.013 15.4 0.1 0.023 14.7 0.1 1.3 1 0 0 1 1 1 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ DASH_Duo1 PF08651.10 ETO22646.1 - 0.043 13.6 0.8 2.5 7.9 0.3 2.4 1 1 1 2 2 2 0 DASH complex subunit Duo1 MtrB PF05440.12 ETO22646.1 - 0.24 11.9 0.7 0.99 9.9 0.3 2.0 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B DUF1664 PF07889.12 ETO22646.1 - 0.28 11.2 2.8 0.19 11.8 0.5 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Sec20 PF03908.13 ETO22646.1 - 0.4 10.6 3.6 0.24 11.3 0.9 1.9 2 0 0 2 2 2 0 Sec20 Thioredoxin PF00085.20 ETO22648.1 - 4.9e-07 29.7 1.6 5.8e-07 29.5 0.2 1.7 2 0 0 2 2 2 1 Thioredoxin TraF PF13728.6 ETO22648.1 - 1.8e-05 24.7 0.1 1.8e-05 24.7 0.1 1.9 1 1 0 2 2 2 1 F plasmid transfer operon protein SpoIISA_toxin PF14171.6 ETO22648.1 - 0.062 13.0 2.3 0.17 11.5 0.2 2.1 1 1 1 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system BRCT PF00533.26 ETO22648.1 - 0.062 13.7 0.2 0.38 11.2 0.1 2.1 1 1 1 2 2 2 0 BRCA1 C Terminus (BRCT) domain Thioredoxin_2 PF13098.6 ETO22648.1 - 0.098 13.1 0.3 0.46 11.0 0.0 2.1 2 0 0 2 2 2 0 Thioredoxin-like domain SbcD_C PF12320.8 ETO22648.1 - 0.24 11.7 4.5 0.1 12.9 0.9 2.1 2 1 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain Exonuc_VII_L PF02601.15 ETO22648.1 - 0.43 10.1 4.4 0.62 9.6 4.4 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sod_Fe_C PF02777.18 ETO22649.1 - 6.7e-38 129.0 1.0 1e-37 128.4 1.0 1.3 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ETO22649.1 - 3.7e-14 52.9 0.4 8e-14 51.9 0.4 1.5 1 0 0 1 1 1 1 Iron/manganese superoxide dismutases, alpha-hairpin domain Tubulin_3 PF14881.6 ETO22650.1 - 9.1e-07 28.7 0.1 2.9e-06 27.1 0.1 1.9 1 1 0 1 1 1 1 Tubulin domain Pex24p PF06398.11 ETO22651.1 - 5.9e-07 28.8 12.5 7.7e-07 28.4 12.5 1.2 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Vps62 PF06101.11 ETO22651.1 - 6.4e-07 28.1 0.0 1e-06 27.4 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Ribosomal_L36e PF01158.18 ETO22652.1 - 1.8 8.8 7.5 2 8.7 0.2 2.7 3 0 0 3 3 3 0 Ribosomal protein L36e SesA PF17107.5 ETO22654.1 - 0.019 15.1 2.7 0.05 13.8 2.7 1.7 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases CCDC-167 PF15188.6 ETO22654.1 - 1.3 9.4 9.7 0.56 10.6 6.1 2.3 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 DUF2951 PF11166.8 ETO22654.1 - 3 8.1 12.8 0.15 12.3 1.5 3.8 5 0 0 5 5 5 0 Protein of unknown function (DUF2951) RabGAP-TBC PF00566.18 ETO22655.1 - 8.5e-25 87.7 0.3 8.5e-25 87.7 0.3 2.7 3 0 0 3 3 3 1 Rab-GTPase-TBC domain REPA_OB_2 PF16900.5 ETO22656.1 - 0.0025 17.7 0.4 0.0038 17.1 0.4 1.3 1 0 0 1 1 1 1 Replication protein A OB domain BsuBI_PstI_RE PF06616.11 ETO22656.1 - 0.0093 15.3 1.3 0.019 14.3 1.3 1.6 1 1 0 1 1 1 1 BsuBI/PstI restriction endonuclease domain Orthoreo_P17 PF07272.11 ETO22656.1 - 0.02 14.9 0.3 5.3 7.0 0.4 2.2 2 1 0 2 2 2 0 Orthoreovirus P17 protein DUF3870 PF12986.7 ETO22656.1 - 0.077 13.2 0.5 0.27 11.5 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3870) PAN_1 PF00024.26 ETO22657.1 - 0.0085 16.0 1.4 0.015 15.3 1.4 1.5 1 1 0 1 1 1 1 PAN domain PAN_4 PF14295.6 ETO22657.1 - 0.019 14.8 0.0 0.041 13.8 0.0 1.6 1 0 0 1 1 1 0 PAN domain Ank_2 PF12796.7 ETO22658.1 - 2e-11 44.3 0.6 7.9e-08 32.8 0.3 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO22658.1 - 5.9e-06 26.7 0.1 0.0066 17.0 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO22658.1 - 0.00013 22.1 0.2 0.51 11.1 0.0 3.8 4 1 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO22658.1 - 0.0032 17.7 0.0 1.7 9.1 0.0 2.5 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO22658.1 - 0.0072 16.7 0.1 7.8 7.1 0.0 3.2 4 0 0 4 4 4 2 Ankyrin repeat BLM10_mid PF16507.5 ETO22658.1 - 0.14 10.8 0.0 0.15 10.7 0.0 1.0 1 0 0 1 1 1 0 Proteasome-substrate-size regulator, mid region Ank_2 PF12796.7 ETO22659.1 - 1.2e-22 80.3 1.6 5.9e-15 55.6 0.1 2.6 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO22659.1 - 2.5e-16 59.5 0.1 1.8e-06 28.1 0.0 4.0 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO22659.1 - 2e-15 56.9 0.0 1.3e-06 28.8 0.0 2.7 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO22659.1 - 1.6e-12 47.3 0.0 0.0037 17.6 0.0 4.2 4 1 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ETO22659.1 - 8.1e-12 44.2 0.1 0.0029 17.9 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat BCL9 PF11502.8 ETO22659.1 - 0.062 13.1 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 B-cell lymphoma 9 protein DUF1611_N PF17396.2 ETO22659.1 - 0.12 12.6 0.0 0.22 11.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1611_N) Rossmann-like domain PhoLip_ATPase_N PF16209.5 ETO22660.1 - 1.1e-13 50.7 0.2 2.2e-13 49.7 0.2 1.5 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Complex1_LYR PF05347.15 ETO22660.1 - 0.067 13.2 0.1 2.6 8.2 0.0 2.3 2 0 0 2 2 2 0 Complex 1 protein (LYR family) WD40 PF00400.32 ETO22661.1 - 3.1e-52 173.4 17.3 4.2e-10 40.0 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22661.1 - 9.8e-23 80.3 3.4 0.00067 19.9 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22661.1 - 5.5e-11 42.0 0.6 0.011 14.8 0.0 6.0 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO22661.1 - 1.7e-09 37.9 0.4 1.1e-05 25.4 0.1 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO22661.1 - 2.6e-07 30.3 0.2 0.045 13.1 0.0 3.3 2 2 2 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO22661.1 - 6.7e-07 28.3 1.7 0.12 10.9 0.0 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO22661.1 - 8e-05 21.6 7.3 0.025 13.4 3.3 3.1 1 1 2 3 3 3 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO22661.1 - 0.00098 17.8 0.5 0.08 11.5 0.2 3.1 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO22661.1 - 0.051 12.9 1.7 3 7.1 0.0 3.4 1 1 4 5 5 5 0 Neuroblastoma-amplified sequence, N terminal DUF4988 PF16378.5 ETO22661.1 - 0.095 12.4 1.4 8.6 6.0 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function PD40 PF07676.12 ETO22661.1 - 0.29 11.1 8.1 12 5.9 0.1 4.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Spore_YhaL PF14147.6 ETO22662.1 - 1.7 8.4 5.1 24 4.7 3.1 2.6 2 0 0 2 2 2 0 Sporulation protein YhaL BTB_2 PF02214.22 ETO22663.1 - 0.00018 21.8 0.0 0.61 10.5 0.0 3.0 1 1 1 2 2 2 2 BTB/POZ domain Pkinase PF00069.25 ETO22664.1 - 7.6e-61 205.8 0.9 1e-60 205.3 0.9 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22664.1 - 7.9e-37 126.9 1.0 9.9e-37 126.6 1.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO22664.1 - 8.1e-09 35.1 0.5 1.8e-08 34.0 0.5 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO22664.1 - 6.4e-07 29.0 0.0 9.6e-07 28.4 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO22664.1 - 9.4e-06 24.7 0.1 4.2e-05 22.5 0.0 2.0 2 1 0 2 2 2 1 Fungal protein kinase RIO1 PF01163.22 ETO22664.1 - 0.002 17.7 1.0 0.022 14.4 0.2 2.2 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 ETO22664.1 - 0.0036 16.9 0.3 0.016 14.7 0.0 2.0 2 0 0 2 2 2 1 PhoP regulatory network protein YrbL FTA2 PF13095.6 ETO22664.1 - 0.021 14.5 0.5 0.06 13.0 0.0 1.8 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF3155 PF11352.8 ETO22664.1 - 0.029 14.8 0.3 0.077 13.4 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3155) APH PF01636.23 ETO22664.1 - 0.087 12.7 0.0 0.14 12.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pox_Ag35 PF03286.14 ETO22665.1 - 9.1 6.0 26.1 2.9 7.6 5.0 2.4 1 1 1 2 2 2 0 Pox virus Ag35 surface protein DUF3439 PF11921.8 ETO22666.1 - 1.3 9.0 6.8 0.11 12.4 1.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) WD40 PF00400.32 ETO22667.1 - 1.3e-120 389.7 57.1 6.7e-09 36.2 0.2 16.9 17 0 0 17 17 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22667.1 - 9.5e-24 83.5 16.9 0.35 11.2 0.0 13.1 2 1 11 14 14 13 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO22667.1 - 1.1e-13 51.2 20.0 0.005 16.2 0.0 8.0 3 1 4 9 9 9 6 WD40-like domain NACHT PF05729.12 ETO22667.1 - 6e-09 36.0 0.0 1.1e-08 35.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO22667.1 - 9.5e-08 31.5 2.0 1.9e-07 30.6 2.0 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO22667.1 - 4.9e-05 23.4 3.4 36 4.6 0.0 8.4 9 3 3 12 12 12 0 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO22667.1 - 0.0002 21.4 0.1 0.00054 20.1 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO22667.1 - 0.0023 18.1 0.6 0.0059 16.7 0.6 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO22667.1 - 0.046 14.0 0.1 0.25 11.6 0.1 2.3 2 1 0 2 2 1 0 AAA domain IL15 PF02372.15 ETO22667.1 - 0.057 13.4 2.7 0.11 12.5 0.6 2.7 2 0 0 2 2 2 0 Interleukin 15 AAA_18 PF13238.6 ETO22667.1 - 0.12 13.0 0.5 0.84 10.2 0.0 2.8 2 0 0 2 2 2 0 AAA domain Tox-PLDMTX PF15645.6 ETO22667.1 - 0.19 12.0 3.9 0.29 11.4 1.1 2.7 3 0 0 3 3 2 0 Dermonecrotoxin of the Papain-like fold Cytochrom_D1 PF02239.16 ETO22667.1 - 0.5 8.8 10.2 2.3 6.7 0.1 4.8 2 1 3 6 6 6 0 Cytochrome D1 heme domain DUF1068 PF06364.12 ETO22667.1 - 0.74 9.7 3.5 1.5 8.7 0.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) UPRTase PF14681.6 ETO22668.1 - 2.6e-05 23.8 0.0 5.4e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase FAM176 PF14851.6 ETO22668.1 - 1.9 8.1 4.4 9.8 5.8 4.4 2.1 1 1 0 1 1 1 0 FAM176 family PHTB1_N PF14727.6 ETO22669.1 - 0.046 13.1 0.0 0.053 12.9 0.0 1.1 1 0 0 1 1 1 0 PTHB1 N-terminus RabGAP-TBC PF00566.18 ETO22669.1 - 0.069 12.8 6.5 0.96 9.1 0.2 2.8 3 0 0 3 3 3 0 Rab-GTPase-TBC domain RabGAP-TBC PF00566.18 ETO22670.1 - 1.9e-08 34.2 1.7 8.4e-08 32.1 1.7 2.4 1 1 0 1 1 1 1 Rab-GTPase-TBC domain DUF1168 PF06658.12 ETO22671.1 - 7.2e-19 68.0 21.0 7.2e-19 68.0 21.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1168) RR_TM4-6 PF06459.12 ETO22671.1 - 0.88 9.3 17.7 1.3 8.8 17.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 ETO22671.1 - 4.6 6.0 10.3 5.4 5.7 10.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF92 PF01940.16 ETO22672.1 - 0.15 11.4 0.2 0.15 11.4 0.2 1.7 1 1 1 2 2 2 0 Integral membrane protein DUF92 DUF3537 PF12056.8 ETO22672.1 - 0.49 9.2 2.3 0.63 8.8 2.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) CDC45 PF02724.14 ETO22672.1 - 3 6.0 12.4 3.6 5.8 12.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO22672.1 - 3.2 6.9 7.2 3.6 6.7 7.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter YL1 PF05764.13 ETO22673.1 - 0.4 10.8 38.9 0.065 13.4 23.2 2.1 1 1 1 2 2 2 0 YL1 nuclear protein Nop14 PF04147.12 ETO22673.1 - 3.8 5.6 33.8 5.1 5.2 33.8 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3708 PF12501.8 ETO22674.1 - 0.044 13.6 1.3 0.097 12.5 1.3 1.6 1 0 0 1 1 1 0 Phosphate ATP-binding cassette transporter HEAT PF02985.22 ETO22674.1 - 0.062 13.6 2.1 13 6.3 0.1 2.7 2 0 0 2 2 2 0 HEAT repeat YMF19 PF02326.15 ETO22674.1 - 4.7 8.1 11.0 0.24 12.2 1.6 3.2 3 0 0 3 3 3 0 Plant ATP synthase F0 SEEEED PF14797.6 ETO22675.1 - 0.44 10.7 8.9 0.59 10.3 8.9 1.1 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Myb_DNA-binding PF00249.31 ETO22676.1 - 8.5e-06 25.9 0.0 1.5e-05 25.1 0.0 1.4 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO22676.1 - 0.0024 18.1 0.0 0.0055 16.9 0.0 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain PIN_3 PF13470.6 ETO22676.1 - 0.036 14.8 0.0 0.053 14.3 0.0 1.3 1 0 0 1 1 1 0 PIN domain Voltage_CLC PF00654.20 ETO22677.1 - 0.065 12.5 4.5 0.21 10.8 0.1 2.1 1 1 1 2 2 2 0 Voltage gated chloride channel SUIM_assoc PF16619.5 ETO22677.1 - 1 9.5 5.8 0.74 9.9 4.0 1.8 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pox_Ag35 PF03286.14 ETO22679.1 - 0.013 15.3 2.3 0.018 14.9 2.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein UPF0220 PF05255.11 ETO22680.1 - 0.023 14.3 1.8 0.17 11.5 0.4 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0220) E1-E2_ATPase PF00122.20 ETO22681.1 - 4.1 6.9 4.7 10 5.6 0.2 2.2 2 0 0 2 2 2 0 E1-E2 ATPase Oxidored_q5_N PF01059.17 ETO22681.1 - 8.7 6.5 22.3 0.033 14.3 4.7 3.4 2 1 1 3 3 3 0 NADH-ubiquinone oxidoreductase chain 4, amino terminus LRR_4 PF12799.7 ETO22682.1 - 5.4e-42 141.1 107.5 5.4e-06 26.7 7.2 14.9 10 3 2 15 15 15 13 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO22682.1 - 1.7e-35 120.6 81.8 4.4e-08 32.8 7.2 11.8 6 3 4 11 11 11 10 Leucine rich repeat LRR_9 PF14580.6 ETO22682.1 - 5.3e-27 94.4 42.3 1.8e-09 37.3 7.0 8.1 4 4 3 8 8 8 6 Leucine-rich repeat LRR_6 PF13516.6 ETO22682.1 - 0.0015 18.5 67.7 0.22 11.6 0.1 15.0 17 0 0 17 17 17 6 Leucine Rich repeat RNR_Alpha PF17975.1 ETO22682.1 - 0.087 13.3 0.7 0.32 11.5 0.7 2.0 1 0 0 1 1 1 0 Ribonucleotide reductase alpha domain HSP70 PF00012.20 ETO22684.1 - 7.3e-21 74.0 2.0 2.1e-12 46.0 0.0 2.9 1 1 2 3 3 3 2 Hsp70 protein PilM_2 PF11104.8 ETO22684.1 - 0.13 11.3 0.0 0.21 10.6 0.0 1.2 1 0 0 1 1 1 0 Type IV pilus assembly protein PilM; WD40 PF00400.32 ETO22686.1 - 2.2e-65 215.0 22.6 2e-10 41.1 0.1 8.8 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22686.1 - 9.8e-20 70.7 5.0 0.038 14.3 0.1 8.2 3 1 6 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22686.1 - 6.2e-19 68.1 1.3 2.5e-05 23.4 0.0 7.4 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO22686.1 - 2.3e-05 23.1 0.5 1.5 7.2 0.0 4.8 2 1 3 5 5 5 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO22686.1 - 2.4e-05 24.1 7.1 2.9 7.9 0.0 6.8 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO22686.1 - 0.0061 16.5 0.9 0.024 14.6 0.3 2.4 2 0 0 2 2 2 1 Kelch motif Gmad1 PF10647.9 ETO22686.1 - 0.0067 16.2 0.1 0.088 12.5 0.0 2.3 1 1 1 2 2 2 1 Lipoprotein LpqB beta-propeller domain Nbas_N PF15492.6 ETO22686.1 - 0.011 15.1 1.2 1.2 8.4 0.0 3.6 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal DUF1921 PF09081.10 ETO22686.1 - 0.12 12.6 0.0 4.9 7.5 0.0 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1921) Kelch_1 PF01344.25 ETO22686.1 - 1.9 8.1 6.4 0.73 9.5 0.3 2.8 3 0 0 3 3 3 0 Kelch motif Sel1 PF08238.12 ETO22690.1 - 0.00015 22.3 2.3 0.056 14.2 0.1 3.9 3 1 1 4 4 4 2 Sel1 repeat PH_12 PF16457.5 ETO22691.1 - 0.025 15.1 0.0 0.075 13.6 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain RPEL PF02755.15 ETO22692.1 - 2.2e-12 46.2 7.8 1.9 8.3 0.1 7.9 8 0 0 8 8 8 6 RPEL repeat Ish1 PF10281.9 ETO22692.1 - 0.00026 21.2 4.6 7.8 6.9 0.0 5.8 5 1 0 5 5 5 2 Putative stress-responsive nuclear envelope protein Thioredoxin_3 PF13192.6 ETO22692.1 - 0.00037 20.5 5.2 37 4.5 0.0 5.8 4 1 2 6 6 6 1 Thioredoxin domain Methyltransf_18 PF12847.7 ETO22692.1 - 0.39 10.6 10.8 13 5.7 0.1 5.2 4 1 2 6 6 6 0 Methyltransferase domain Viral_Beta_CD PF04530.12 ETO22693.1 - 0.036 14.4 2.7 0.091 13.1 2.7 1.7 1 0 0 1 1 1 0 Viral Beta C/D like family RasGEF_N PF00618.20 ETO22693.1 - 6.3 7.1 8.8 43 4.4 8.8 2.6 1 1 0 1 1 1 0 RasGEF N-terminal motif NOA36 PF06524.12 ETO22694.1 - 0.83 8.9 5.4 2.1 7.6 5.4 1.6 1 0 0 1 1 1 0 NOA36 protein Macoilin PF09726.9 ETO22696.1 - 8.9 4.7 13.8 11 4.4 13.8 1.1 1 0 0 1 1 1 0 Macoilin family RRM_5 PF13893.6 ETO22697.1 - 3.6e-25 88.0 1.3 4.7e-23 81.1 1.2 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO22697.1 - 5.5e-14 51.7 0.1 8.4e-06 25.5 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO22697.1 - 0.001 18.9 0.0 0.019 14.8 0.0 2.3 2 0 0 2 2 2 1 Occluded RNA-recognition motif SpoIIIAH PF12685.7 ETO22698.1 - 0.0043 16.9 7.6 0.0098 15.7 7.6 1.5 1 1 0 1 1 1 1 SpoIIIAH-like protein Nop14 PF04147.12 ETO22698.1 - 0.006 14.9 12.0 0.0082 14.4 12.0 1.1 1 0 0 1 1 1 1 Nop14-like family Menin PF05053.13 ETO22698.1 - 0.027 12.9 6.2 0.034 12.5 6.2 1.1 1 0 0 1 1 1 0 Menin SDA1 PF05285.12 ETO22698.1 - 0.057 12.8 9.8 0.08 12.4 9.8 1.2 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 ETO22698.1 - 0.26 10.0 9.1 0.46 9.2 9.1 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PNISR PF15996.5 ETO22698.1 - 0.33 11.2 5.2 0.49 10.6 5.2 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF2457 PF10446.9 ETO22698.1 - 1 8.4 23.1 1.6 7.8 23.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.12 ETO22698.1 - 1.1 8.9 21.3 2.1 8.0 21.3 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Zip PF02535.22 ETO22698.1 - 1.2 8.2 4.9 2 7.6 4.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Raftlin PF15250.6 ETO22698.1 - 2 7.1 5.3 2.9 6.5 5.3 1.2 1 0 0 1 1 1 0 Raftlin Presenilin PF01080.17 ETO22698.1 - 2.4 6.9 7.4 3.3 6.4 7.4 1.1 1 0 0 1 1 1 0 Presenilin Otopetrin PF03189.13 ETO22699.1 - 9.2 5.0 10.0 13 4.4 10.0 1.2 1 0 0 1 1 1 0 Otopetrin MRG PF05712.13 ETO22700.1 - 3.6e-09 36.2 0.2 3.6e-09 36.2 0.2 1.8 2 0 0 2 2 2 1 MRG Tudor-knot PF11717.8 ETO22700.1 - 5.2e-06 26.2 5.3 9e-06 25.5 1.7 2.7 3 0 0 3 3 3 1 RNA binding activity-knot of a chromodomain Agenet PF05641.12 ETO22700.1 - 0.016 15.7 0.8 0.037 14.5 0.8 1.6 1 0 0 1 1 1 0 Agenet domain UPF0061 PF02696.14 ETO22700.1 - 0.19 10.5 3.5 0.19 10.5 2.6 1.4 1 1 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family DUF4023 PF13215.6 ETO22700.1 - 0.27 11.3 4.5 0.53 10.3 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4023) 4HBT PF03061.22 ETO22701.1 - 0.0084 16.4 0.0 3.6 8.0 0.0 2.8 2 0 0 2 2 2 2 Thioesterase superfamily Kinesin PF00225.23 ETO22702.1 - 9.3e-24 84.0 0.0 1.5e-23 83.3 0.0 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO22702.1 - 1.4e-19 70.5 0.0 2.9e-19 69.5 0.0 1.5 2 0 0 2 2 2 1 Microtubule binding Saccharop_dh_N PF04455.12 ETO22702.1 - 0.025 15.0 0.0 0.045 14.1 0.0 1.4 1 0 0 1 1 1 0 LOR/SDH bifunctional enzyme conserved region KASH PF10541.9 ETO22703.1 - 0.0071 16.6 0.7 0.0071 16.6 0.7 2.5 2 0 0 2 2 2 1 Nuclear envelope localisation domain OppC_N PF12911.7 ETO22703.1 - 0.081 12.9 1.0 1.8 8.6 0.3 2.4 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C T4_deiodinase PF00837.17 ETO22704.1 - 8.5e-17 61.2 0.1 1.2e-16 60.7 0.1 1.2 1 0 0 1 1 1 1 Iodothyronine deiodinase DUF2457 PF10446.9 ETO22704.1 - 0.17 11.0 3.9 0.22 10.6 3.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Afi1 PF07792.12 ETO22705.1 - 0.29 11.6 26.7 0.47 10.9 8.3 2.9 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking TraV PF09676.10 ETO22705.1 - 0.3 12.1 18.3 1.1 10.2 8.5 3.2 3 0 0 3 3 3 0 Type IV conjugative transfer system lipoprotein (TraV) LMBR1 PF04791.16 ETO22705.1 - 1.6 7.5 15.1 2.5 6.9 15.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Hph PF13694.6 ETO22706.1 - 1 9.6 11.4 2.1 8.6 11.4 1.5 1 1 0 1 1 1 0 Sec63/Sec62 complex-interacting family Ribosomal_S26e PF01283.19 ETO22707.1 - 2e-39 134.3 8.0 2.9e-39 133.8 7.0 1.7 1 1 1 2 2 2 1 Ribosomal protein S26e Interfer-bind PF09294.10 ETO22707.1 - 0.51 10.7 0.1 0.51 10.7 0.1 2.3 2 1 1 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III EMC1_C PF07774.13 ETO22708.1 - 3.1e-44 151.2 0.1 7.8e-44 149.9 0.1 1.7 1 1 0 1 1 1 1 ER membrane protein complex subunit 1, C-terminal PQQ PF01011.21 ETO22708.1 - 0.11 12.5 0.1 0.52 10.3 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat Kinase-like PF14531.6 ETO22709.1 - 0.00041 19.8 0.1 0.00075 18.9 0.1 1.4 1 0 0 1 1 1 1 Kinase-like DUF5427 PF10310.9 ETO22710.1 - 0.015 14.3 0.1 0.015 14.3 0.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5427) DUF2722 PF10846.8 ETO22711.1 - 0.0055 15.7 3.4 0.0055 15.7 3.4 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Eapp_C PF10238.9 ETO22711.1 - 0.0097 16.0 2.1 0.017 15.2 2.1 1.4 1 0 0 1 1 1 1 E2F-associated phosphoprotein SpoIIP PF07454.11 ETO22711.1 - 0.087 12.3 7.6 0.014 14.9 4.1 1.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) FAM176 PF14851.6 ETO22711.1 - 0.16 11.6 2.0 0.27 10.9 2.0 1.3 1 0 0 1 1 1 0 FAM176 family DUF4820 PF16091.5 ETO22711.1 - 0.72 9.2 4.6 1.2 8.4 4.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) MAM33 PF02330.16 ETO22711.1 - 0.82 9.6 10.0 0.77 9.7 8.1 1.7 1 1 0 2 2 2 0 Mitochondrial glycoprotein TPR_1 PF00515.28 ETO22712.1 - 1.4e-12 46.8 6.0 5.2e-06 26.1 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22712.1 - 6.2e-09 35.3 2.1 0.0038 17.2 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22712.1 - 2.9e-07 30.2 0.7 0.033 14.4 0.0 4.3 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO22712.1 - 5.4e-05 23.2 0.0 0.018 15.2 0.0 3.0 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO22712.1 - 0.0014 18.8 0.3 0.91 9.9 0.0 3.2 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22712.1 - 0.061 13.7 1.5 84 3.9 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF1563 PF07599.11 ETO22714.1 - 0.041 14.0 0.1 0.095 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1563) TIM21 PF08294.11 ETO22714.1 - 0.14 12.0 1.4 0.28 11.0 0.1 2.1 3 0 0 3 3 3 0 TIM21 TipAS PF07739.13 ETO22716.1 - 0.065 13.8 1.2 0.14 12.7 1.2 1.5 1 0 0 1 1 1 0 TipAS antibiotic-recognition domain Isy1 PF06246.12 ETO22717.1 - 0.0044 16.6 0.6 0.0044 16.6 0.6 3.3 1 1 1 2 2 2 1 Isy1-like splicing family Calici_coat_C PF08435.11 ETO22717.1 - 0.3 10.6 3.0 0.25 10.8 0.7 1.9 2 0 0 2 2 2 0 Calicivirus coat protein C-terminal RP-C_C PF11800.8 ETO22717.1 - 3.8 7.5 0.0 3.8 7.5 0.0 3.2 2 1 0 2 2 2 0 Replication protein C C-terminal region zf-H2C2_2 PF13465.6 ETO22718.1 - 1.4e-06 28.5 15.2 9.6e-06 25.8 1.1 3.5 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO22718.1 - 1.2e-05 25.7 11.5 0.0014 19.3 1.1 2.6 2 0 0 2 2 2 2 C2H2-type zinc finger SR-25 PF10500.9 ETO22718.1 - 0.0024 17.6 7.5 0.0042 16.7 7.5 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Dsh_C PF12316.8 ETO22718.1 - 0.019 15.4 6.6 0.022 15.1 6.6 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Secretin_N_2 PF07655.13 ETO22718.1 - 0.022 15.3 11.2 0.03 14.9 11.2 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4614 PF15391.6 ETO22718.1 - 0.061 13.3 5.8 0.081 12.9 5.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) zf-C2H2_11 PF16622.5 ETO22718.1 - 0.061 13.1 1.2 0.48 10.2 0.1 2.5 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2 PF00096.26 ETO22718.1 - 0.083 13.4 12.9 0.57 10.8 1.2 2.6 2 0 0 2 2 2 0 Zinc finger, C2H2 type CCDC106 PF15794.5 ETO22718.1 - 0.19 11.4 3.8 0.26 11.0 3.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 zf-C2HE PF16278.5 ETO22718.1 - 0.22 12.0 10.0 4.5 7.8 10.0 2.6 1 1 0 1 1 1 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_3rep PF18868.1 ETO22718.1 - 0.39 11.4 7.9 12 6.6 3.5 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_jaz PF12171.8 ETO22718.1 - 0.39 11.1 0.3 0.39 11.1 0.3 2.7 2 0 0 2 2 2 0 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 ETO22718.1 - 4.3 7.4 18.7 0.3 11.2 3.0 3.2 2 2 1 3 3 3 0 BED zinc finger zf-C5HC2 PF02928.16 ETO22720.1 - 4.3e-09 36.6 12.0 1.2e-08 35.2 12.0 1.8 1 0 0 1 1 1 1 C5HC2 zinc finger ARID PF01388.21 ETO22721.1 - 3.8e-10 40.3 0.3 8.3e-10 39.2 0.3 1.6 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain C1_1 PF00130.22 ETO22721.1 - 5.4e-05 23.0 1.2 5.4e-05 23.0 1.2 3.1 2 1 1 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 ETO22721.1 - 0.0022 17.9 8.7 0.0022 17.9 8.7 2.9 3 0 0 3 3 3 1 PHD-finger FYVE_2 PF02318.16 ETO22721.1 - 0.0082 16.4 2.1 0.027 14.7 2.1 1.8 1 0 0 1 1 1 1 FYVE-type zinc finger NAAA-beta PF15508.6 ETO22721.1 - 0.08 13.3 0.2 0.25 11.7 0.0 1.9 2 0 0 2 2 2 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Prok-RING_1 PF14446.6 ETO22721.1 - 0.11 12.4 8.5 0.14 12.1 6.7 2.1 1 1 0 1 1 1 0 Prokaryotic RING finger family 1 PHD_2 PF13831.6 ETO22721.1 - 0.53 9.9 10.7 4.8 6.8 4.0 3.2 3 0 0 3 3 3 0 PHD-finger RGS PF00615.19 ETO22722.1 - 0.0021 18.3 5.3 0.0091 16.3 3.5 2.4 1 1 0 1 1 1 1 Regulator of G protein signaling domain CH PF00307.31 ETO22723.1 - 0.049 13.8 0.1 0.098 12.9 0.1 1.5 1 0 0 1 1 1 0 Calponin homology (CH) domain Ndc1_Nup PF09531.10 ETO22723.1 - 0.12 11.1 2.0 0.14 10.9 2.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Atrophin-1 PF03154.15 ETO22723.1 - 0.67 8.2 9.8 1.1 7.5 9.8 1.3 1 0 0 1 1 1 0 Atrophin-1 family Phage_HK97_TLTM PF06120.11 ETO22723.1 - 2.4 7.3 11.8 3.5 6.7 11.8 1.1 1 0 0 1 1 1 0 Tail length tape measure protein LMBR1 PF04791.16 ETO22723.1 - 8.2 5.2 5.2 10 4.9 5.2 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3886 PF13025.6 ETO22724.1 - 3.1 8.1 7.9 5.2 7.3 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) Metallophos PF00149.28 ETO22725.1 - 0.0009 19.8 2.7 0.029 14.9 2.7 2.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase zf-C2H2 PF00096.26 ETO22725.1 - 0.028 14.9 1.1 0.028 14.9 1.1 2.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-H2C2_5 PF13909.6 ETO22725.1 - 1.5 8.6 8.7 0.16 11.7 1.1 2.5 2 0 0 2 2 2 0 C2H2-type zinc-finger domain Glycoamylase PF10091.9 ETO22726.1 - 0.0064 16.1 0.0 0.014 14.9 0.0 1.5 1 0 0 1 1 1 1 Putative glucoamylase Neur_chan_memb PF02932.16 ETO22726.1 - 0.0069 16.5 0.3 0.22 11.5 0.9 2.4 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region Exonuc_VIII PF06630.11 ETO22726.1 - 0.011 15.7 1.7 0.017 15.0 1.7 1.2 1 0 0 1 1 1 0 Enterobacterial exodeoxyribonuclease VIII DUF4407 PF14362.6 ETO22726.1 - 0.026 13.9 0.9 0.039 13.3 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Nop16 PF09420.10 ETO22726.1 - 0.62 10.1 16.0 1.5 8.8 13.3 2.3 1 1 0 2 2 2 0 Ribosome biogenesis protein Nop16 CDC45 PF02724.14 ETO22726.1 - 3.2 5.9 14.9 4.6 5.4 14.9 1.1 1 0 0 1 1 1 0 CDC45-like protein PGA2 PF07543.12 ETO22726.1 - 6 6.8 13.7 13 5.8 13.7 1.6 1 0 0 1 1 1 0 Protein trafficking PGA2 Ank_2 PF12796.7 ETO22727.1 - 9.2e-06 26.2 0.0 0.012 16.2 0.0 2.5 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO22727.1 - 0.00024 21.3 0.0 0.0088 16.5 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat DUF4290 PF14123.6 ETO22727.1 - 0.02 14.4 0.4 0.042 13.4 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4290) Ank PF00023.30 ETO22727.1 - 0.033 14.6 0.1 0.12 12.9 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeat Ank_4 PF13637.6 ETO22727.1 - 0.046 14.3 0.0 0.16 12.6 0.0 1.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) GPCR_chapero_1 PF11904.8 ETO22728.1 - 1.1e-15 57.9 0.0 2.6e-08 33.7 0.3 2.0 1 1 1 2 2 2 2 GPCR-chaperone DUF4412 PF14371.6 ETO22728.1 - 0.17 11.7 0.8 1.9 8.2 0.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4412) MRI PF15325.6 ETO22729.1 - 2.3 9.4 6.5 0.43 11.7 1.3 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection Qua1 PF16274.5 ETO22729.1 - 9.5 6.1 6.5 3.1 7.7 0.1 3.2 4 0 0 4 4 4 0 Qua1 domain WD40 PF00400.32 ETO22730.1 - 5.4e-06 27.0 3.3 0.015 16.1 0.5 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat YqgF PF14639.6 ETO22731.1 - 3.9e-17 62.4 0.0 1.1e-16 61.0 0.0 1.7 1 1 1 2 2 2 1 Holliday-junction resolvase-like of SPT6 HHH_7 PF14635.6 ETO22731.1 - 2.5e-09 37.4 0.0 4.4e-09 36.6 0.0 1.4 1 0 0 1 1 1 1 Helix-hairpin-helix motif Tex_YqgF PF16921.5 ETO22731.1 - 0.0053 17.2 0.0 0.018 15.5 0.0 1.9 2 0 0 2 2 2 1 Tex protein YqgF-like domain Pep_deformylase PF01327.21 ETO22732.1 - 0.0068 16.0 0.5 0.012 15.3 0.5 1.4 1 0 0 1 1 1 1 Polypeptide deformylase DUF2052 PF09747.9 ETO22732.1 - 4.7 7.3 11.0 4 7.5 9.2 1.9 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) zf-TRAF PF02176.18 ETO22733.1 - 1.2e-06 29.1 4.5 1.2e-06 29.1 4.5 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger WD40 PF00400.32 ETO22734.1 - 1.1e-40 136.9 23.5 1.8e-05 25.4 0.5 8.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO22734.1 - 2e-13 49.9 11.8 0.00028 19.7 0.4 5.8 2 2 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO22734.1 - 1e-10 41.8 1.4 0.24 11.7 0.0 5.8 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO22734.1 - 4.2e-05 24.1 1.9 4.2e-05 24.1 1.9 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger FapA PF03961.13 ETO22734.1 - 0.0032 16.2 3.2 0.0046 15.6 3.2 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF4446 PF14584.6 ETO22734.1 - 0.015 15.3 2.5 0.015 15.3 2.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4446) GCD14 PF08704.10 ETO22734.1 - 0.029 14.1 0.6 0.064 12.9 0.6 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit HAUS5 PF14817.6 ETO22734.1 - 0.029 13.1 1.8 0.041 12.7 1.8 1.1 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 5 ADIP PF11559.8 ETO22734.1 - 0.041 14.0 9.5 0.1 12.7 9.5 1.6 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 ETO22734.1 - 0.11 12.0 2.2 0.18 11.3 2.2 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1664 PF07889.12 ETO22734.1 - 0.14 12.2 1.3 0.42 10.7 1.3 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) FlaC_arch PF05377.11 ETO22734.1 - 0.24 11.8 2.9 0.72 10.3 2.9 1.8 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Lectin_N PF03954.14 ETO22734.1 - 0.28 10.9 6.7 0.39 10.5 5.3 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Ax_dynein_light PF10211.9 ETO22734.1 - 0.31 11.0 9.2 0.21 11.5 7.1 1.8 1 1 0 1 1 1 0 Axonemal dynein light chain DUF4482 PF14818.6 ETO22734.1 - 0.32 11.8 6.8 0.72 10.7 6.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) CENP-F_leu_zip PF10473.9 ETO22734.1 - 0.9 9.6 12.8 1.9 8.5 12.8 1.5 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DivIC PF04977.15 ETO22734.1 - 1 9.2 6.5 0.4 10.5 0.3 2.6 1 1 1 2 2 2 0 Septum formation initiator Laminin_II PF06009.12 ETO22734.1 - 1.2 9.1 6.9 2.4 8.2 6.9 1.4 1 0 0 1 1 1 0 Laminin Domain II Swi5 PF07061.11 ETO22734.1 - 6.7 6.9 9.3 0.82 9.8 4.6 2.0 2 0 0 2 2 1 0 Swi5 WD40 PF00400.32 ETO22735.1 - 2.2e-53 177.0 11.4 4e-10 40.1 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22735.1 - 6e-16 58.5 2.2 0.0011 19.2 0.0 6.8 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22735.1 - 6.4e-11 41.8 0.1 0.49 9.3 0.0 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO22735.1 - 4.3e-05 22.4 2.3 0.033 12.8 0.3 4.8 1 1 3 5 5 5 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO22735.1 - 0.0026 17.2 16.0 0.011 15.1 0.2 4.8 5 1 1 6 6 6 2 WD40-like domain Kelch_6 PF13964.6 ETO22735.1 - 0.0038 17.4 0.2 0.48 10.8 0.1 3.4 3 0 0 3 3 2 1 Kelch motif Cytochrom_D1 PF02239.16 ETO22735.1 - 0.011 14.3 0.2 5.5 5.4 0.0 3.1 2 1 1 3 3 3 0 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO22735.1 - 0.081 12.2 0.2 13 5.0 0.0 2.7 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO22735.1 - 0.2 11.7 5.5 13 5.8 0.0 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO22735.1 - 0.22 11.5 2.2 27 4.9 0.1 3.5 4 0 0 4 4 4 0 Kelch motif DUF4763 PF15960.5 ETO22735.1 - 0.41 9.9 5.3 0.73 9.1 5.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Methyltransf_12 PF08242.12 ETO22738.1 - 0.031 15.0 0.0 0.051 14.3 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase domain Sld5 PF05916.11 ETO22739.1 - 1.8e-17 63.7 0.2 2.4e-17 63.4 0.2 1.2 1 0 0 1 1 1 1 GINS complex protein PTPS PF01242.19 ETO22742.1 - 0.1 12.6 0.1 0.33 10.9 0.1 1.8 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase zf-TRAF PF02176.18 ETO22743.1 - 2.4e-06 28.1 1.8 2.4e-06 28.1 1.8 2.9 2 0 0 2 2 2 1 TRAF-type zinc finger Mito_carr PF00153.27 ETO22745.1 - 2.2e-41 139.7 1.2 1.5e-16 60.0 0.0 3.1 3 0 0 3 3 3 3 Mitochondrial carrier protein Ras PF00071.22 ETO22746.1 - 5.2e-19 68.4 0.1 8e-19 67.8 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO22746.1 - 4.4e-15 56.0 0.1 8.5e-15 55.0 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO22746.1 - 0.0048 16.4 0.1 0.0076 15.7 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family TniB PF05621.11 ETO22746.1 - 0.1 12.0 0.0 0.36 10.2 0.0 1.7 2 0 0 2 2 2 0 Bacterial TniB protein AAA_16 PF13191.6 ETO22746.1 - 0.13 12.7 0.0 0.27 11.6 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Pkinase PF00069.25 ETO22748.1 - 2.1e-13 50.2 0.1 2.2e-12 46.9 0.0 2.1 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22748.1 - 0.073 12.3 0.0 0.12 11.7 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase DUF999 PF06198.11 ETO22749.1 - 3 7.9 5.1 5.9 6.9 2.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF999) AMOP PF03782.17 ETO22749.1 - 5.4 7.1 14.6 0.63 10.1 7.9 2.1 1 1 1 2 2 2 0 AMOP domain Pkinase PF00069.25 ETO22751.1 - 5.8e-20 71.8 0.7 9.7e-20 71.0 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22751.1 - 2.3e-17 63.1 0.1 4e-17 62.3 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO22751.1 - 0.0091 15.4 3.9 0.015 14.7 3.5 1.5 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YL1 PF05764.13 ETO22751.1 - 0.016 15.3 14.5 0.11 12.6 0.3 2.2 2 0 0 2 2 2 0 YL1 nuclear protein RPN2_C PF18004.1 ETO22751.1 - 0.063 13.2 13.2 0.075 12.9 1.9 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Prothymosin PF03247.14 ETO22751.1 - 0.1 13.1 33.2 0.094 13.2 15.0 2.3 2 0 0 2 2 2 0 Prothymosin/parathymosin family RXT2_N PF08595.11 ETO22751.1 - 0.15 12.1 16.1 0.14 12.2 2.7 2.3 2 0 0 2 2 2 0 RXT2-like, N-terminal FAM176 PF14851.6 ETO22751.1 - 0.59 9.8 16.4 0.13 11.9 5.1 2.3 2 0 0 2 2 2 0 FAM176 family TRAP_alpha PF03896.16 ETO22751.1 - 0.66 9.1 15.4 0.37 9.9 3.7 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF4637 PF15470.6 ETO22751.1 - 0.8 9.4 16.5 0.13 11.9 3.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) RPA43_OB PF17875.1 ETO22751.1 - 2 9.0 8.9 6.7 7.4 1.9 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Cwf_Cwc_15 PF04889.12 ETO22751.1 - 2.9 7.5 26.1 1.3 8.7 8.1 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETO22751.1 - 3.1 7.0 25.2 0.084 12.2 6.5 2.2 2 0 0 2 2 2 0 NOA36 protein PPP4R2 PF09184.11 ETO22751.1 - 3.2 7.3 24.0 2.7 7.5 10.9 2.1 2 0 0 2 2 2 0 PPP4R2 DUF1676 PF07898.13 ETO22751.1 - 4.3 7.3 8.3 0.57 10.2 2.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Afi1 PF07792.12 ETO22751.1 - 5.4 7.5 16.2 4.3 7.8 2.6 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PBP1_TM PF14812.6 ETO22751.1 - 7.1 7.1 19.0 14 6.2 6.2 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TMEM107 PF14995.6 ETO22753.1 - 0.94 9.9 7.3 46 4.5 7.3 2.4 1 1 0 1 1 1 0 Transmembrane protein GET2 PF08690.10 ETO22753.1 - 1.4 8.5 6.5 2.2 7.9 6.5 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 AA_permease_2 PF13520.6 ETO22753.1 - 7.6 5.2 8.3 0.83 8.4 1.2 1.9 1 1 1 2 2 2 0 Amino acid permease Actin PF00022.19 ETO22754.1 - 1.2e-39 136.1 0.0 2e-21 76.1 0.0 3.0 2 1 0 2 2 2 2 Actin DUF1201 PF06716.11 ETO22755.1 - 1.3 9.1 8.3 1.4 9.0 0.6 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1201) SLBP_RNA_bind PF15247.6 ETO22756.1 - 2.9e-20 72.1 0.6 2.9e-20 72.1 0.6 2.0 2 1 0 2 2 2 1 Histone RNA hairpin-binding protein RNA-binding domain HTH_ABP1_N PF18107.1 ETO22756.1 - 0.058 13.1 0.5 0.058 13.1 0.5 2.2 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain zf-C2H2_6 PF13912.6 ETO22756.1 - 2.6 8.1 9.7 0.23 11.5 4.7 1.9 2 0 0 2 2 2 0 C2H2-type zinc finger MutS_I PF01624.20 ETO22758.1 - 0.035 14.4 0.0 0.41 10.9 0.0 2.5 1 1 0 1 1 1 0 MutS domain I MutS_V PF00488.21 ETO22759.1 - 5.3e-81 271.2 0.3 5.3e-81 271.2 0.3 1.8 2 0 0 2 2 2 1 MutS domain V MutS_III PF05192.18 ETO22759.1 - 2.6e-34 119.1 3.6 5.4e-34 118.1 0.5 2.6 2 1 0 2 2 2 1 MutS domain III MutS_IV PF05190.18 ETO22759.1 - 4.7e-08 33.3 1.3 1.7e-07 31.5 0.4 2.4 2 0 0 2 2 2 1 MutS family domain IV AAA_27 PF13514.6 ETO22759.1 - 0.013 15.1 3.7 0.025 14.2 0.0 3.1 4 0 0 4 4 4 0 AAA domain CK2S PF15011.6 ETO22759.1 - 0.38 10.6 6.3 7.8 6.4 0.0 3.5 3 0 0 3 3 3 0 Casein Kinase 2 substrate SKA1 PF07160.12 ETO22760.1 - 0.00018 21.4 0.4 0.00047 20.1 0.3 1.6 1 1 1 2 2 2 1 Spindle and kinetochore-associated protein 1 zf-H2C2_2 PF13465.6 ETO22760.1 - 0.013 15.9 4.5 2.7 8.6 0.9 2.5 2 0 0 2 2 2 0 Zinc-finger double domain WD40 PF00400.32 ETO22761.1 - 1.5e-55 183.8 20.4 1.7e-09 38.2 0.3 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22761.1 - 1.4e-15 57.3 5.8 0.002 18.4 0.1 5.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22761.1 - 2e-12 46.7 2.6 0.026 13.5 0.0 5.6 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO22761.1 - 1.7e-05 24.4 5.3 0.17 11.2 0.3 4.4 1 1 2 3 3 3 2 WD40-like domain DUF5570 PF17731.1 ETO22761.1 - 0.00033 20.7 1.5 7.8 6.6 0.0 4.0 2 1 1 4 4 4 1 Family of unknown function (DUF5570) Kelch_6 PF13964.6 ETO22761.1 - 0.019 15.3 1.6 25 5.4 0.0 4.6 4 0 0 4 4 4 0 Kelch motif PD40 PF07676.12 ETO22761.1 - 0.043 13.8 0.4 8.1 6.5 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF4763 PF15960.5 ETO22761.1 - 0.062 12.6 3.2 0.11 11.7 3.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Kelch_1 PF01344.25 ETO22761.1 - 0.11 12.1 0.2 4.2 7.0 0.0 2.9 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO22761.1 - 0.12 12.4 1.1 6.1 6.9 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain Zip PF02535.22 ETO22762.1 - 0.18 11.0 2.2 0.23 10.6 2.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO22762.1 - 1.4 7.2 13.2 1.9 6.7 13.2 1.1 1 0 0 1 1 1 0 Menin Macoilin PF09726.9 ETO22762.1 - 4.9 5.6 12.0 6.2 5.2 12.0 1.1 1 0 0 1 1 1 0 Macoilin family NOA36 PF06524.12 ETO22762.1 - 7.1 5.8 11.6 9.5 5.4 11.6 1.1 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO22762.1 - 7.6 5.2 9.3 11 4.7 9.3 1.3 1 0 0 1 1 1 0 Presenilin EF-hand_6 PF13405.6 ETO22764.1 - 0.023 14.6 0.0 0.075 13.0 0.0 1.9 2 0 0 2 2 2 0 EF-hand domain AAA_17 PF13207.6 ETO22765.1 - 0.044 14.2 0.5 0.064 13.7 0.5 1.2 1 0 0 1 1 1 0 AAA domain Melibiase PF02065.18 ETO22765.1 - 0.048 12.6 0.0 0.062 12.2 0.0 1.1 1 0 0 1 1 1 0 Melibiase DUF4168 PF13767.6 ETO22765.1 - 0.13 13.5 4.5 0.19 12.9 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4168) zf-MYND PF01753.18 ETO22765.1 - 0.85 9.8 12.1 2.2 8.5 3.4 2.6 2 0 0 2 2 2 0 MYND finger FAM176 PF14851.6 ETO22765.1 - 2.2 7.9 6.9 3.8 7.2 6.9 1.3 1 0 0 1 1 1 0 FAM176 family DUF3959 PF13105.6 ETO22766.1 - 0.98 8.9 2.0 3.1 7.2 2.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) zf-Nse PF11789.8 ETO22767.1 - 3e-13 49.4 0.1 5.4e-13 48.6 0.1 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit zf-MIZ PF02891.20 ETO22767.1 - 3.5e-05 23.4 0.3 7.5e-05 22.4 0.3 1.5 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger zf-RING_UBOX PF13445.6 ETO22767.1 - 0.052 13.6 0.6 0.14 12.2 0.6 1.7 1 0 0 1 1 1 0 RING-type zinc-finger S-AdoMet_synt_N PF00438.20 ETO22769.1 - 0.047 14.4 0.8 0.075 13.7 0.7 1.4 1 1 0 1 1 1 0 S-adenosylmethionine synthetase, N-terminal domain Presenilin PF01080.17 ETO22769.1 - 0.17 10.6 5.6 0.18 10.5 5.6 1.2 1 0 0 1 1 1 0 Presenilin Band_3_cyto PF07565.13 ETO22769.1 - 0.34 10.7 7.4 0.38 10.5 7.4 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Neur_chan_memb PF02932.16 ETO22769.1 - 1.7 8.7 9.7 2 8.4 9.7 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF3314 PF11771.8 ETO22769.1 - 5.5 7.1 11.6 0.48 10.5 6.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3314) Hydin_ADK PF17213.3 ETO22769.1 - 7 6.9 8.3 8.1 6.7 8.3 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain PH PF00169.29 ETO22770.1 - 9.1e-11 42.2 2.6 1.2e-10 41.8 0.1 2.2 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO22770.1 - 0.00015 22.0 0.0 0.00015 22.0 0.0 1.9 2 0 0 2 2 2 1 Pleckstrin homology domain PH_3 PF14593.6 ETO22770.1 - 0.006 16.7 1.7 0.019 15.0 1.1 2.2 1 1 1 2 2 2 1 PH domain PH_2 PF08458.10 ETO22770.1 - 0.0071 16.7 0.1 0.017 15.5 0.1 1.6 1 0 0 1 1 1 1 Plant pleckstrin homology-like region PH_13 PF16652.5 ETO22770.1 - 0.012 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_11 PF15413.6 ETO22770.1 - 0.028 14.9 3.0 0.032 14.7 0.1 2.5 2 2 0 2 2 2 0 Pleckstrin homology domain Cauli_DNA-bind PF03310.13 ETO22770.1 - 0.028 14.5 0.1 0.069 13.2 0.1 1.7 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein MIF4G PF02854.19 ETO22771.1 - 0.18 11.4 2.2 0.19 11.3 0.5 1.9 2 0 0 2 2 2 0 MIF4G domain YhhN PF07947.14 ETO22772.1 - 2.1e-15 56.8 6.4 2.1e-15 56.8 6.4 1.5 2 0 0 2 2 2 1 YhhN family Lig_chan PF00060.26 ETO22772.1 - 0.065 13.1 0.9 0.16 11.8 0.9 1.7 1 0 0 1 1 1 0 Ligand-gated ion channel GPS PF01825.21 ETO22773.1 - 4.3e-06 27.1 10.3 1.8e-05 25.2 10.3 2.2 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif ADH_zinc_N PF00107.26 ETO22774.1 - 3.7e-10 39.9 0.0 5.2e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Apis_Csd PF11671.8 ETO22775.1 - 1.7 8.7 31.5 0.039 14.0 22.2 2.3 2 0 0 2 2 2 0 Complementary sex determiner protein CAC1F_C PF16885.5 ETO22775.1 - 2.3 7.8 27.0 3 7.4 27.0 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term LAP1C PF05609.12 ETO22775.1 - 5.4 6.0 35.9 9.6 5.2 35.9 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Utp14 PF04615.13 ETO22775.1 - 6.7 5.2 53.5 8.7 4.8 53.5 1.0 1 0 0 1 1 1 0 Utp14 protein Thioredoxin_7 PF13899.6 ETO22776.1 - 2.2e-06 27.7 0.1 1e-05 25.6 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin-like Beta_helix PF13229.6 ETO22776.1 - 0.0062 16.4 5.4 0.0094 15.8 5.4 1.2 1 0 0 1 1 1 1 Right handed beta helix region UPF0182 PF03699.13 ETO22778.1 - 0.03 12.5 1.4 0.044 11.9 1.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0182) DUF4231 PF14015.6 ETO22778.1 - 0.056 13.9 0.9 2.8 8.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4231) PhoR PF11808.8 ETO22778.1 - 0.51 10.8 2.7 1.1 9.7 1.8 2.0 2 0 0 2 2 2 0 Phosphate regulon sensor protein PhoR DUF1129 PF06570.11 ETO22778.1 - 1.3 8.4 5.9 7.3 6.0 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) RasGEF PF00617.19 ETO22779.1 - 7.6e-53 179.3 0.7 1.5e-52 178.4 0.7 1.5 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETO22779.1 - 0.00049 20.3 0.1 0.0017 18.6 0.1 1.9 1 0 0 1 1 1 1 RasGEF N-terminal motif DUF1944 PF09175.10 ETO22779.1 - 0.013 15.3 0.2 0.045 13.6 0.0 2.0 3 0 0 3 3 3 0 Domain of unknown function (DUF1944) AAA_lid_7 PF17867.1 ETO22779.1 - 0.03 14.5 0.2 0.079 13.2 0.2 1.7 1 0 0 1 1 1 0 Midasin AAA lid domain WD40 PF00400.32 ETO22780.1 - 3.3e-13 49.9 3.8 6.3e-05 23.7 0.0 5.5 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO22780.1 - 0.00021 20.1 2.0 0.07 11.8 0.0 3.1 2 1 1 3 3 3 2 Nucleoporin Nup120/160 IKI3 PF04762.12 ETO22780.1 - 0.00087 17.4 0.4 0.076 11.0 0.1 2.2 1 1 1 2 2 2 2 IKI3 family Ge1_WD40 PF16529.5 ETO22780.1 - 0.0046 16.0 0.1 0.011 14.7 0.1 1.6 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO22780.1 - 0.037 14.3 0.5 8.9 6.7 0.3 3.2 1 1 2 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Kinesin PF00225.23 ETO22781.1 - 7.3e-07 28.4 0.0 7.3e-07 28.4 0.0 2.7 2 1 0 2 2 2 1 Kinesin motor domain Peptidase_S49_N PF08496.10 ETO22781.1 - 0.07 13.2 4.8 0.16 12.0 0.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal HALZ PF02183.18 ETO22782.1 - 0.17 12.2 9.2 0.42 10.9 9.2 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Glyco_hydro_35 PF01301.19 ETO22783.1 - 1.7e-43 149.4 5.4 6.2e-25 88.5 0.1 3.2 3 0 0 3 3 3 2 Glycosyl hydrolases family 35 SET PF00856.28 ETO22783.1 - 1.5e-20 74.3 0.2 4.9e-20 72.6 0.0 1.9 2 0 0 2 2 2 1 SET domain Pre-SET PF05033.16 ETO22783.1 - 6e-05 23.7 0.8 6e-05 23.7 0.8 2.8 3 0 0 3 3 3 1 Pre-SET motif Ricin_B_lectin PF00652.22 ETO22783.1 - 0.00021 21.5 0.3 0.00021 21.5 0.3 2.9 3 0 0 3 3 3 1 Ricin-type beta-trefoil lectin domain NifU PF01106.17 ETO22783.1 - 0.076 13.2 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 NifU-like domain DUF454 PF04304.13 ETO22783.1 - 0.22 11.5 0.5 0.52 10.4 0.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF454) Sulfate_transp PF00916.20 ETO22785.1 - 8.3e-24 84.0 1.1 1.3e-23 83.4 1.1 1.3 1 0 0 1 1 1 1 Sulfate permease family SDA1 PF05285.12 ETO22785.1 - 0.00039 20.0 13.8 0.00044 19.8 13.8 1.1 1 0 0 1 1 1 1 SDA1 Tim54 PF11711.8 ETO22785.1 - 0.0038 16.1 0.0 0.0044 15.8 0.0 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Mpp10 PF04006.12 ETO22785.1 - 0.12 10.8 21.3 0.15 10.5 21.3 1.1 1 0 0 1 1 1 0 Mpp10 protein DNA_pol_phi PF04931.13 ETO22785.1 - 0.27 9.3 34.4 0.4 8.7 34.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi RNA_pol_Rpc4 PF05132.14 ETO22785.1 - 0.51 10.7 4.4 0.71 10.3 4.4 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 BUD22 PF09073.10 ETO22785.1 - 5.9 6.1 23.0 7.3 5.8 23.0 1.1 1 0 0 1 1 1 0 BUD22 FAM221 PF14753.6 ETO22786.1 - 0.0048 16.5 1.6 0.01 15.4 1.6 1.5 1 0 0 1 1 1 1 Protein FAM221A/B TEP1_N PF05386.11 ETO22786.1 - 0.14 11.7 0.3 0.27 10.9 0.3 1.4 1 0 0 1 1 1 0 TEP1 N-terminal domain Neur_chan_memb PF02932.16 ETO22786.1 - 5 7.1 8.7 0.84 9.7 3.2 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region zf-C3HC4_2 PF13923.6 ETO22787.1 - 2.1e-11 43.5 12.9 2.1e-11 43.5 12.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ETO22787.1 - 6.1e-09 35.6 4.5 1.1e-08 34.8 4.5 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 ETO22787.1 - 2.3e-08 34.2 11.2 2.3e-08 34.2 11.2 2.1 3 0 0 3 3 2 1 Ring finger domain zf-C3HC4 PF00097.25 ETO22787.1 - 2.9e-07 30.2 13.7 2.9e-07 30.2 13.7 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO22787.1 - 1e-06 28.5 13.0 1e-06 28.5 11.0 2.1 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO22787.1 - 1.5e-05 24.9 14.6 2.5e-05 24.1 12.1 2.5 3 0 0 3 3 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO22787.1 - 1.7e-05 24.7 6.3 1.7e-05 24.7 6.3 3.0 4 1 1 5 5 3 1 RING-type zinc-finger zf-C3HC4_4 PF15227.6 ETO22787.1 - 5.4e-05 23.3 11.4 0.00019 21.5 11.4 2.0 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-Nse PF11789.8 ETO22787.1 - 0.00012 21.8 5.5 0.00028 20.6 5.5 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Prok-RING_4 PF14447.6 ETO22787.1 - 0.0057 16.5 13.6 0.042 13.7 11.0 2.9 2 1 1 3 3 3 1 Prokaryotic RING finger family 4 zf-C3HC4_5 PF17121.5 ETO22787.1 - 0.041 13.8 9.7 0.16 11.9 9.7 2.1 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ETO22787.1 - 0.077 12.8 12.6 0.42 10.4 12.9 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain zf-rbx1 PF12678.7 ETO22787.1 - 0.14 12.5 13.4 0.088 13.1 9.9 2.5 2 1 0 2 2 2 0 RING-H2 zinc finger domain zf-UDP PF14569.6 ETO22787.1 - 1.5 9.0 7.9 4.1 7.6 7.9 1.8 1 1 0 1 1 1 0 Zinc-binding RING-finger zf-C2H2 PF00096.26 ETO22788.1 - 3.8e-07 30.2 19.9 0.028 14.9 1.4 3.7 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO22788.1 - 8.5e-07 29.1 13.9 0.18 12.3 0.5 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO22788.1 - 0.00027 21.5 22.8 0.076 13.9 1.5 4.2 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 ETO22788.1 - 0.024 15.0 0.4 0.024 15.0 0.4 2.1 2 0 0 2 2 2 0 Zinc-finger of C2H2 type Ta0938 PF11494.8 ETO22788.1 - 0.065 13.5 0.8 0.14 12.4 0.2 1.9 2 0 0 2 2 2 0 Ta0938 zf-Di19 PF05605.12 ETO22788.1 - 0.071 13.4 11.5 0.28 11.5 4.0 2.6 2 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding FOXP-CC PF16159.5 ETO22788.1 - 0.075 13.7 0.5 0.075 13.7 0.5 2.1 2 0 0 2 2 2 0 FOXP coiled-coil domain zf-C2H2_jaz PF12171.8 ETO22788.1 - 0.096 13.0 11.9 0.46 10.8 0.4 3.8 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding GP44 PF17510.2 ETO22788.1 - 0.16 12.2 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Gene product 44 zf-C2HE PF16278.5 ETO22788.1 - 0.2 12.1 5.2 3.3 8.2 1.0 2.8 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger zf-C2H2_6 PF13912.6 ETO22788.1 - 4 7.6 10.9 1 9.4 0.4 3.4 3 0 0 3 3 3 0 C2H2-type zinc finger EF-hand_12 PF17901.1 ETO22789.1 - 0.042 14.3 1.4 0.092 13.2 1.4 1.5 1 0 0 1 1 1 0 EF-hand fold domain Hydrolase_6 PF13344.6 ETO22790.1 - 9.3e-21 73.8 0.1 7.8e-20 70.9 0.0 2.1 2 0 0 2 2 2 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETO22790.1 - 9.4e-18 64.1 0.0 2.5e-17 62.7 0.0 1.7 1 0 0 1 1 1 1 HAD-hyrolase-like Hydrolase PF00702.26 ETO22790.1 - 0.00019 21.8 0.3 0.26 11.5 0.1 2.7 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Adeno_Penton_B PF01686.17 ETO22790.1 - 0.035 12.6 0.1 0.056 11.9 0.1 1.2 1 0 0 1 1 1 0 Adenovirus penton base protein 7TM_GPCR_Srt PF10321.9 ETO22790.1 - 0.11 11.4 1.7 0.17 10.9 1.7 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srt Exonuc_VII_L PF02601.15 ETO22791.1 - 0.0052 16.4 4.3 0.0081 15.8 4.3 1.3 1 1 0 1 1 1 1 Exonuclease VII, large subunit FapA PF03961.13 ETO22791.1 - 0.029 13.0 9.4 0.044 12.4 9.4 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A SKA2 PF16740.5 ETO22791.1 - 0.029 14.1 1.9 0.029 14.1 1.9 3.0 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DivIC PF04977.15 ETO22791.1 - 0.047 13.5 10.4 2.5 7.9 0.1 3.5 3 1 0 3 3 3 0 Septum formation initiator TPR_MLP1_2 PF07926.12 ETO22791.1 - 0.12 12.4 16.7 0.065 13.3 3.9 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein FlxA PF14282.6 ETO22791.1 - 0.15 12.0 10.0 0.066 13.2 2.7 2.3 2 0 0 2 2 2 0 FlxA-like protein LPP PF04728.13 ETO22791.1 - 0.17 12.3 4.0 5.8 7.4 0.3 2.8 3 0 0 3 3 3 0 Lipoprotein leucine-zipper Snapin_Pallidin PF14712.6 ETO22791.1 - 0.29 11.6 6.7 0.81 10.2 0.2 3.0 3 0 0 3 3 3 0 Snapin/Pallidin DUF5082 PF16888.5 ETO22791.1 - 0.33 11.2 13.7 0.61 10.4 1.3 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) Prefoldin_2 PF01920.20 ETO22791.1 - 0.36 10.8 13.3 0.95 9.4 0.1 3.4 3 1 0 3 3 3 0 Prefoldin subunit Allexi_40kDa PF05549.11 ETO22791.1 - 0.73 9.3 3.9 0.69 9.4 0.9 2.0 2 0 0 2 2 2 0 Allexivirus 40kDa protein Seryl_tRNA_N PF02403.22 ETO22791.1 - 1.4 9.2 19.3 1.5 9.1 1.4 3.3 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain HBM PF16591.5 ETO22791.1 - 2.1 7.7 7.8 1.7 8.0 0.3 2.5 2 1 0 2 2 2 0 Helical bimodular sensor domain TSC22 PF01166.18 ETO22791.1 - 2.3 8.6 8.7 3 8.2 0.6 3.2 2 1 1 3 3 3 0 TSC-22/dip/bun family GPS2_interact PF15784.5 ETO22791.1 - 2.6 8.5 8.1 3.9 8.0 0.5 2.9 2 1 1 3 3 3 0 G-protein pathway suppressor 2-interacting domain BLOC1_2 PF10046.9 ETO22791.1 - 3 8.2 10.3 6.5 7.1 0.1 3.3 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 E2F_CC-MB PF16421.5 ETO22791.1 - 3.5 8.0 7.1 1.2 9.6 0.2 2.7 2 1 0 2 2 2 0 E2F transcription factor CC-MB domain Fib_alpha PF08702.10 ETO22791.1 - 5.7 7.1 11.1 10 6.3 0.5 3.0 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family GARP PF16731.5 ETO22791.1 - 6.1 6.5 13.4 1.5 8.4 3.8 2.9 2 1 2 4 4 4 0 Glutamic acid/alanine-rich protein of Trypanosoma XhlA PF10779.9 ETO22791.1 - 8.4 6.7 8.1 2.5 8.4 0.2 2.8 3 0 0 3 3 3 0 Haemolysin XhlA Rad51 PF08423.11 ETO22792.1 - 2.3e-26 92.6 0.5 2.9e-26 92.3 0.5 1.1 1 0 0 1 1 1 1 Rad51 HHH_5 PF14520.6 ETO22792.1 - 1.1e-06 29.1 0.0 2.6e-06 27.9 0.0 1.6 1 0 0 1 1 1 1 Helix-hairpin-helix domain RecA PF00154.21 ETO22792.1 - 6.1e-05 22.6 0.0 8.8e-05 22.1 0.0 1.2 1 0 0 1 1 1 1 recA bacterial DNA recombination protein ATPase PF06745.13 ETO22792.1 - 0.0003 20.2 0.3 0.00061 19.2 0.3 1.5 1 0 0 1 1 1 1 KaiC PAXNEB PF05625.11 ETO22792.1 - 0.04 13.1 0.0 0.064 12.4 0.0 1.3 1 0 0 1 1 1 0 PAXNEB protein HHH_3 PF12836.7 ETO22792.1 - 0.057 13.7 0.3 1.8 8.9 0.0 2.3 2 0 0 2 2 2 0 Helix-hairpin-helix motif SKA1 PF07160.12 ETO22793.1 - 0.0091 15.9 2.8 0.0091 15.9 2.8 2.4 2 0 0 2 2 2 1 Spindle and kinetochore-associated protein 1 DUF948 PF06103.11 ETO22793.1 - 0.11 12.8 0.3 0.11 12.8 0.3 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) CDC45 PF02724.14 ETO22793.1 - 0.3 9.3 12.8 0.05 11.9 7.5 1.9 2 0 0 2 2 2 0 CDC45-like protein Zip PF02535.22 ETO22793.1 - 0.44 9.7 3.9 0.44 9.7 3.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2052 PF09747.9 ETO22793.1 - 5.9 7.0 18.3 0.68 10.0 13.7 1.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Vfa1 PF08432.10 ETO22793.1 - 7.8 6.8 18.5 0.51 10.7 12.2 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 FSA_C PF10479.9 ETO22794.1 - 0.016 13.3 8.5 0.027 12.6 8.5 1.4 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3439 PF11921.8 ETO22794.1 - 1.7 8.6 16.0 5.4 7.0 15.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3439) RNA_pol_3_Rpc31 PF11705.8 ETO22795.1 - 0.011 16.0 10.2 0.019 15.2 10.2 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CAP_GLY PF01302.25 ETO22796.1 - 1.2e-10 41.2 0.2 2.6e-10 40.2 0.2 1.5 1 0 0 1 1 1 1 CAP-Gly domain YabA PF06156.13 ETO22796.1 - 4.2 8.1 9.6 0.38 11.4 0.9 2.9 3 0 0 3 3 3 0 Initiation control protein YabA DUF3915 PF13054.6 ETO22797.1 - 0.42 10.6 8.6 2.3 8.2 2.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Kelch_4 PF13418.6 ETO22799.1 - 1.5e-07 31.3 0.2 0.0019 18.2 0.0 4.0 3 1 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO22799.1 - 9.6e-07 28.3 0.1 0.00046 19.7 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO22799.1 - 0.00012 22.2 0.1 3.5 8.1 0.1 4.1 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO22799.1 - 0.47 10.8 5.6 7.7 6.9 0.1 3.9 3 1 0 3 3 3 0 Galactose oxidase, central domain Xpo1 PF08389.12 ETO22800.1 - 9.3e-06 25.8 0.6 5.8e-05 23.2 0.0 2.4 2 1 0 2 2 2 1 Exportin 1-like protein DUF5347 PF17282.2 ETO22800.1 - 0.042 14.1 0.6 1.6 9.1 0.1 2.6 2 1 1 3 3 3 0 Family of unknown function (DUF5347) DUF1764 PF08576.10 ETO22801.1 - 8.1 7.4 8.7 0.79 10.7 2.1 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) CAP_GLY PF01302.25 ETO22803.1 - 7.8e-17 61.1 0.2 1.2e-16 60.4 0.2 1.3 1 0 0 1 1 1 1 CAP-Gly domain DUF92 PF01940.16 ETO22803.1 - 0.18 11.2 0.1 0.25 10.7 0.1 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 DUF2615 PF11027.8 ETO22803.1 - 0.26 11.5 4.4 8.7 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) Aldose_epim PF01263.20 ETO22804.1 - 5.1e-49 167.2 0.7 8e-49 166.6 0.7 1.2 1 0 0 1 1 1 1 Aldose 1-epimerase SLC12 PF03522.15 ETO22804.1 - 0.011 14.8 0.2 0.016 14.2 0.2 1.2 1 0 0 1 1 1 0 Solute carrier family 12 tRNA_NucTran2_2 PF13735.6 ETO22805.1 - 0.054 13.5 1.9 0.16 12.0 1.9 1.7 1 0 0 1 1 1 0 tRNA nucleotidyltransferase domain 2 putative Troponin PF00992.20 ETO22805.1 - 0.42 10.9 5.2 0.23 11.8 0.2 2.8 3 1 0 3 3 3 0 Troponin TFIIF_alpha PF05793.12 ETO22807.1 - 3.9e-06 25.8 38.0 3.9e-06 25.8 38.0 2.1 1 1 0 2 2 2 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4604 PF15377.6 ETO22807.1 - 0.00031 21.2 32.5 0.00039 20.9 22.4 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4604) Dishevelled PF02377.15 ETO22807.1 - 0.007 16.8 0.3 0.007 16.8 0.3 2.7 2 1 0 2 2 2 1 Dishevelled specific domain SDA1 PF05285.12 ETO22807.1 - 0.27 10.6 35.8 0.023 14.2 26.2 2.1 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ETO22807.1 - 0.29 9.3 38.5 0.013 13.8 29.7 2.0 2 0 0 2 2 2 0 Nop14-like family DUF2457 PF10446.9 ETO22807.1 - 0.31 10.1 33.8 0.045 12.9 23.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) RR_TM4-6 PF06459.12 ETO22807.1 - 0.45 10.3 27.3 0.22 11.3 16.7 2.4 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DNA_pol_phi PF04931.13 ETO22807.1 - 3.8 5.5 28.5 7.4 4.5 28.5 1.5 1 0 0 1 1 1 0 DNA polymerase phi Aa_trans PF01490.18 ETO22809.1 - 2.5e-06 26.5 1.5 0.00036 19.3 0.3 2.1 2 0 0 2 2 2 2 Transmembrane amino acid transporter protein EphA2_TM PF14575.6 ETO22811.1 - 0.05 14.5 0.5 0.36 11.8 0.0 2.4 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain TMEM51 PF15345.6 ETO22811.1 - 0.29 10.9 7.3 0.11 12.3 1.4 2.4 2 1 0 2 2 2 0 Transmembrane protein 51 Skp1 PF01466.19 ETO22812.1 - 7.3e-15 54.8 2.7 1.2e-14 54.2 0.8 2.3 2 0 0 2 2 2 1 Skp1 family, dimerisation domain GPW_gp25 PF04965.14 ETO22812.1 - 0.051 13.4 0.0 0.089 12.6 0.0 1.4 1 0 0 1 1 1 0 Gene 25-like lysozyme RPN2_C PF18004.1 ETO22812.1 - 0.47 10.3 5.7 0.84 9.5 5.7 1.4 1 1 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4469 PF14734.6 ETO22813.1 - 0.13 12.4 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4469) with IG-like fold DUF3671 PF12420.8 ETO22814.1 - 0.6 10.2 12.0 0.2 11.7 1.5 2.4 1 1 1 2 2 2 0 Protein of unknown function Virul_fac_BrkB PF03631.15 ETO22814.1 - 1.8 8.1 14.4 0.13 11.8 7.0 2.2 1 1 1 2 2 2 0 Virulence factor BrkB Abhydrolase_9_N PF15420.6 ETO22814.1 - 3.5 7.6 6.7 1.9 8.4 2.5 2.3 1 1 1 2 2 2 0 Alpha/beta-hydrolase family N-terminus SLATT_4 PF18186.1 ETO22815.1 - 0.024 14.3 2.4 0.025 14.2 0.3 2.0 1 1 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 LPG_synthase_TM PF03706.13 ETO22815.1 - 0.03 13.8 10.6 0.057 12.9 6.2 2.7 2 1 0 2 2 2 0 Lysylphosphatidylglycerol synthase TM region AP3D1 PF06375.11 ETO22815.1 - 0.1 12.8 6.5 0.15 12.3 6.5 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 CitMHS PF03600.16 ETO22815.1 - 1.5 7.9 5.8 25 4.0 5.8 2.3 1 1 0 1 1 1 0 Citrate transporter OAD_gamma PF04277.13 ETO22815.1 - 4.9 7.8 10.7 27 5.5 5.8 3.2 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain EF-hand_8 PF13833.6 ETO22816.1 - 1.4e-06 28.0 0.0 4.6e-06 26.4 0.0 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO22816.1 - 1.3e-05 24.4 0.0 4.6e-05 22.7 0.0 2.0 1 0 0 1 1 1 1 EF hand XK-related PF09815.9 ETO22816.1 - 2.5e-05 23.5 5.4 2.5e-05 23.5 5.4 1.7 1 1 0 1 1 1 1 XK-related protein EF-hand_4 PF12763.7 ETO22816.1 - 0.00038 20.4 0.0 0.0018 18.2 0.0 2.1 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_6 PF13405.6 ETO22816.1 - 0.00094 18.9 0.0 0.0036 17.1 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain EF-hand_5 PF13202.6 ETO22816.1 - 0.0012 18.3 0.0 0.0032 16.9 0.0 1.7 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO22816.1 - 0.014 15.9 0.0 0.035 14.5 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain pair Spore_YhcN_YlaJ PF09580.10 ETO22816.1 - 0.017 15.2 0.1 0.017 15.2 0.1 3.6 3 0 0 3 3 3 0 Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ) zf-C2H2 PF00096.26 ETO22817.1 - 5.4e-05 23.4 26.0 0.0014 19.0 2.9 4.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-Di19 PF05605.12 ETO22817.1 - 0.0012 19.1 6.3 0.0012 19.1 6.3 3.7 3 1 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding zf-C2H2_4 PF13894.6 ETO22817.1 - 0.016 16.0 25.9 0.031 15.1 3.2 5.0 4 0 0 4 4 4 0 C2H2-type zinc finger zf-LYAR PF08790.11 ETO22817.1 - 0.13 12.2 2.3 0.15 12.0 0.3 2.2 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger KilA-N PF04383.13 ETO22817.1 - 0.14 12.0 3.1 0.17 11.7 1.2 2.1 2 0 0 2 2 2 0 KilA-N domain zf-H2C2_5 PF13909.6 ETO22817.1 - 2.3 8.0 18.4 0.44 10.3 0.6 3.8 3 0 0 3 3 3 0 C2H2-type zinc-finger domain zf-C2H2_11 PF16622.5 ETO22817.1 - 4.5 7.1 8.1 2.2 8.1 0.5 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type zf_C2H2_ZHX PF18387.1 ETO22817.1 - 4.8 6.9 8.1 2.4 7.9 0.4 3.4 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain Kelch_6 PF13964.6 ETO22818.1 - 1.3e-08 34.9 5.2 4.3e-05 23.7 0.1 5.0 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 ETO22818.1 - 0.0023 17.9 0.5 0.03 14.3 0.0 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO22818.1 - 0.035 14.1 2.8 23 5.1 0.0 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO22818.1 - 0.12 12.4 8.0 16 5.7 0.0 4.6 4 1 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO22818.1 - 1.1 8.9 12.2 1.1 9.0 0.2 4.3 4 1 0 4 4 4 0 Kelch motif zf-RING_11 PF17123.5 ETO22819.1 - 1.9e-05 24.3 8.2 2.1e-05 24.2 6.3 2.0 2 0 0 2 2 2 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO22819.1 - 0.0084 15.9 4.3 0.0084 15.9 4.3 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO22819.1 - 0.011 16.0 8.1 0.011 16.0 8.1 2.2 2 0 0 2 2 2 0 Ring finger domain zf-C3HC4 PF00097.25 ETO22819.1 - 0.03 14.2 3.5 0.03 14.2 3.5 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO22819.1 - 0.058 13.4 4.7 0.16 12.0 4.7 1.8 1 0 0 1 1 1 0 RING-type zinc-finger zf-RING_5 PF14634.6 ETO22819.1 - 0.68 9.9 7.1 0.37 10.8 3.0 2.3 2 0 0 2 2 2 0 zinc-RING finger domain DUF2457 PF10446.9 ETO22820.1 - 0.0072 15.5 29.1 0.011 14.9 29.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Cnd2 PF05786.14 ETO22820.1 - 0.25 9.9 26.7 0.33 9.6 26.7 1.1 1 0 0 1 1 1 0 Condensin complex subunit 2 PNISR PF15996.5 ETO22820.1 - 0.31 11.3 13.1 0.46 10.7 13.1 1.4 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CDC45 PF02724.14 ETO22820.1 - 0.42 8.8 22.4 0.53 8.5 22.4 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO22820.1 - 0.79 9.1 30.8 1 8.7 30.8 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO22820.1 - 1.3 7.2 28.7 1.6 6.8 28.7 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO22820.1 - 4.3 6.0 12.2 5.4 5.7 12.2 1.2 1 0 0 1 1 1 0 Presenilin SAPS PF04499.15 ETO22820.1 - 7.8 5.1 20.4 10 4.8 20.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Sulfotransfer_2 PF03567.14 ETO22822.1 - 8.8e-09 35.6 1.0 4.2e-08 33.4 0.2 2.6 2 1 0 2 2 2 1 Sulfotransferase family RRM_1 PF00076.22 ETO22824.1 - 4.7e-20 71.2 0.1 2.7e-09 36.7 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO22824.1 - 0.0032 17.5 0.1 0.95 9.5 0.0 2.5 2 0 0 2 2 2 2 RNA binding motif RRM_7 PF16367.5 ETO22824.1 - 0.0037 17.4 0.0 0.98 9.6 0.0 3.1 2 1 0 2 2 2 2 RNA recognition motif RXT2_N PF08595.11 ETO22825.1 - 0.0058 16.7 4.8 0.0075 16.3 4.8 1.1 1 0 0 1 1 1 1 RXT2-like, N-terminal Atrophin-1 PF03154.15 ETO22825.1 - 0.028 12.7 3.3 0.038 12.3 3.3 1.2 1 0 0 1 1 1 0 Atrophin-1 family DUF3915 PF13054.6 ETO22825.1 - 0.11 12.4 0.5 0.17 11.9 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) COesterase PF00135.28 ETO22826.1 - 0.015 14.2 1.3 0.018 13.9 1.3 1.2 1 0 0 1 1 1 0 Carboxylesterase family SAM_1 PF00536.30 ETO22826.1 - 0.066 13.7 0.1 0.24 11.9 0.1 2.0 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) RGS PF00615.19 ETO22827.1 - 1.7e-06 28.3 0.6 3.1e-06 27.4 0.3 1.7 2 0 0 2 2 2 1 Regulator of G protein signaling domain SAC3 PF12209.8 ETO22827.1 - 0.011 15.9 0.1 0.024 14.8 0.1 1.6 1 0 0 1 1 1 0 Leucine permease transcriptional regulator helical domain CDC24 PF06395.11 ETO22827.1 - 0.025 14.8 1.0 1.5 9.1 0.1 2.2 2 0 0 2 2 2 0 CDC24 Calponin DnaJ PF00226.31 ETO22828.1 - 1.5e-12 47.4 2.9 3.7e-11 43.0 0.0 2.8 2 0 0 2 2 2 1 DnaJ domain DotU PF09850.9 ETO22828.1 - 3.5 7.3 5.8 11 5.6 0.2 2.9 2 1 1 3 3 3 0 Type VI secretion system protein DotU cwf21 PF08312.12 ETO22828.1 - 5.6 7.2 10.5 1.6 9.0 0.5 3.3 3 0 0 3 3 3 0 cwf21 domain zf_UBZ PF18439.1 ETO22829.1 - 0.032 13.8 0.2 0.086 12.4 0.2 1.8 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger AbiEi_3 PF11459.8 ETO22829.1 - 0.065 12.9 0.8 0.13 11.9 0.8 1.6 1 0 0 1 1 1 0 Transcriptional regulator, AbiEi antitoxin, Type IV TA system OrsD PF12013.8 ETO22829.1 - 0.082 13.4 6.2 0.13 12.7 0.2 2.6 2 0 0 2 2 2 0 Orsellinic acid/F9775 biosynthesis cluster protein D Swi3 PF07962.12 ETO22830.1 - 3.7e-15 55.7 0.2 5.5e-15 55.1 0.2 1.3 1 0 0 1 1 1 1 Replication Fork Protection Component Swi3 EF-hand_1 PF00036.32 ETO22831.1 - 5e-06 25.7 2.2 0.0085 15.6 0.1 3.1 3 0 0 3 3 3 2 EF hand EF-hand_5 PF13202.6 ETO22831.1 - 1.4e-05 24.4 2.0 0.0028 17.1 0.1 2.9 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO22831.1 - 1.6e-05 24.4 1.8 0.081 12.9 0.1 3.2 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO22831.1 - 0.00016 22.1 1.5 0.00044 20.6 1.5 1.8 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_8 PF13833.6 ETO22831.1 - 0.00085 19.1 0.2 0.00085 19.1 0.2 2.5 2 1 1 3 3 3 1 EF-hand domain pair Sigma_reg_N PF13800.6 ETO22831.1 - 0.018 15.3 2.2 0.077 13.3 2.2 2.1 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Orf78 PF06024.12 ETO22831.1 - 0.039 14.3 0.6 0.085 13.2 0.6 1.7 1 0 0 1 1 1 0 Orf78 (ac78) Baculo_11_kDa PF06143.11 ETO22831.1 - 0.046 13.3 2.5 0.089 12.4 2.5 1.4 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF4834 PF16118.5 ETO22831.1 - 0.057 14.4 1.7 0.13 13.2 1.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) ECSCR PF15820.5 ETO22831.1 - 0.091 12.6 0.8 0.18 11.6 0.2 1.8 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator Shisa PF13908.6 ETO22831.1 - 0.17 12.1 0.1 0.29 11.4 0.1 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator AsmA PF05170.14 ETO22831.1 - 0.21 10.4 1.7 0.3 9.8 1.7 1.1 1 0 0 1 1 1 0 AsmA family DUF5385 PF17359.2 ETO22831.1 - 0.21 11.1 2.2 0.4 10.2 2.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) DUF2207 PF09972.9 ETO22831.1 - 3.5 6.3 6.0 10 4.8 6.2 1.7 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) tRNA_bind PF01588.20 ETO22832.1 - 6.9e-24 83.8 0.1 1.1e-22 79.9 0.1 2.1 1 1 0 1 1 1 1 Putative tRNA binding domain DSPc PF00782.20 ETO22834.1 - 9e-06 25.5 4.4 2.7 7.8 0.1 5.2 4 0 0 4 4 4 3 Dual specificity phosphatase, catalytic domain Nop53 PF07767.11 ETO22834.1 - 0.0011 18.4 24.0 0.0011 18.4 24.0 3.2 4 0 0 4 4 4 1 Nop53 (60S ribosomal biogenesis) Bromodomain PF00439.25 ETO22834.1 - 0.026 14.6 1.0 0.96 9.6 0.2 2.7 2 0 0 2 2 2 0 Bromodomain CDC45 PF02724.14 ETO22834.1 - 0.18 10.0 40.0 0.74 8.0 8.8 2.3 2 0 0 2 2 2 0 CDC45-like protein DUF2967 PF11179.8 ETO22834.1 - 9.5 4.2 7.1 15 3.5 7.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) zf-UBR PF02207.20 ETO22835.1 - 2.6e-07 30.7 9.7 3.8e-07 30.2 9.7 1.3 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) Rhomboid PF01694.22 ETO22836.1 - 0.0026 17.8 5.4 0.0064 16.5 5.4 1.6 1 0 0 1 1 1 1 Rhomboid family Popeye PF04831.13 ETO22837.1 - 1e-19 71.1 3.1 4.9e-19 68.9 3.7 1.7 2 0 0 2 2 2 1 Popeye protein conserved region DDHD PF02862.17 ETO22837.1 - 0.074 13.2 5.0 0.11 12.6 5.0 1.4 1 0 0 1 1 1 0 DDHD domain Macoilin PF09726.9 ETO22837.1 - 0.95 7.9 16.9 1.1 7.7 16.9 1.1 1 0 0 1 1 1 0 Macoilin family BUD22 PF09073.10 ETO22838.1 - 0.074 12.4 49.8 0.11 11.8 49.8 1.2 1 0 0 1 1 1 0 BUD22 Dapper PF15268.6 ETO22838.1 - 0.41 9.5 24.9 0.48 9.2 24.9 1.1 1 0 0 1 1 1 0 Dapper Macoilin PF09726.9 ETO22838.1 - 5.8 5.3 29.4 6.6 5.2 29.4 1.1 1 0 0 1 1 1 0 Macoilin family Mitofilin PF09731.9 ETO22838.1 - 6.8 5.4 30.8 8 5.2 30.8 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein TPR_2 PF07719.17 ETO22839.1 - 2.9e-35 117.5 15.5 9e-07 28.5 3.8 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22839.1 - 5.6e-35 117.7 16.5 2.2e-08 33.6 5.0 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22839.1 - 4.7e-24 82.5 11.6 0.0012 18.9 0.1 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22839.1 - 1.2e-18 66.5 18.2 5.9e-05 22.7 0.6 7.7 5 3 3 8 8 8 4 TPR repeat TPR_19 PF14559.6 ETO22839.1 - 2.1e-17 63.3 10.4 0.00036 21.0 0.2 6.1 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO22839.1 - 4.2e-17 62.5 5.2 2.4e-08 34.5 0.2 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO22839.1 - 9.8e-16 57.1 0.1 0.022 15.6 0.0 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO22839.1 - 4e-13 48.7 11.0 0.0013 19.0 0.4 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO22839.1 - 1.1e-11 44.8 11.2 0.0023 18.2 2.9 6.7 4 1 3 7 7 7 3 Tetratricopeptide repeat TPR_9 PF13371.6 ETO22839.1 - 8.4e-11 41.9 0.0 0.0048 17.0 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO22839.1 - 8.3e-10 38.8 17.4 0.00019 21.6 3.5 5.2 2 1 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ETO22839.1 - 1.1e-08 34.5 6.1 3.8 7.8 0.0 7.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22839.1 - 2.2e-08 34.2 8.0 0.041 14.5 0.0 6.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO22839.1 - 8.5e-07 28.4 1.0 0.037 13.2 0.2 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat NARP1 PF12569.8 ETO22839.1 - 0.00056 18.9 4.3 0.029 13.3 0.6 2.9 3 1 0 3 3 3 2 NMDA receptor-regulated protein 1 TPR_20 PF14561.6 ETO22839.1 - 0.0012 19.1 3.4 0.61 10.5 0.3 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat PPTA PF01239.22 ETO22839.1 - 0.0081 15.9 0.9 0.58 10.0 0.1 3.1 3 0 0 3 3 2 1 Protein prenyltransferase alpha subunit repeat Alkyl_sulf_dimr PF14863.6 ETO22839.1 - 0.018 15.5 0.2 0.058 13.9 0.2 1.8 1 0 0 1 1 1 0 Alkyl sulfatase dimerisation BTAD PF03704.17 ETO22839.1 - 0.035 14.5 0.2 88 3.5 0.2 3.8 4 0 0 4 4 3 0 Bacterial transcriptional activator domain Fis1_TPR_C PF14853.6 ETO22839.1 - 0.043 13.9 6.4 0.057 13.5 0.2 3.8 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 ETO22839.1 - 0.076 12.9 8.6 8.2 6.5 0.2 5.1 6 0 0 6 6 5 0 Tetratricopeptide repeat DUF454 PF04304.13 ETO22839.1 - 0.083 12.9 0.4 0.19 11.7 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF454) ATP13 PF12921.7 ETO22839.1 - 0.18 11.7 1.3 13 5.6 0.0 2.9 3 0 0 3 3 2 0 Mitochondrial ATPase expression TOM20_plant PF06552.12 ETO22839.1 - 0.24 11.1 3.9 7.6 6.2 0.1 3.7 2 1 0 3 3 3 0 Plant specific mitochondrial import receptor subunit TOM20 SHNi-TPR PF10516.9 ETO22839.1 - 0.38 10.2 5.8 1.5 8.3 0.1 3.8 5 0 0 5 5 5 0 SHNi-TPR WD40 PF00400.32 ETO22840.1 - 2e-07 31.5 0.4 0.027 15.4 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat TPR_1 PF00515.28 ETO22840.1 - 0.00015 21.4 12.4 0.36 10.7 0.0 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO22840.1 - 0.00075 20.0 0.3 0.34 11.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 ETO22840.1 - 0.04 14.2 0.0 7.7 6.9 0.0 3.4 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain TUDOR PF00567.24 ETO22840.1 - 0.06 13.4 0.5 0.18 11.8 0.5 1.8 1 0 0 1 1 1 0 Tudor domain DUF5479 PF17575.2 ETO22840.1 - 0.17 12.5 1.5 0.36 11.4 0.6 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5479) TPR_17 PF13431.6 ETO22840.1 - 0.26 11.8 1.1 1.8 9.1 0.1 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22840.1 - 0.32 11.2 6.1 72 3.9 0.0 5.1 4 2 1 5 5 5 0 Tetratricopeptide repeat TIP120 PF08623.10 ETO22841.1 - 2.5e-42 144.5 4.8 1.9e-41 141.6 0.0 4.4 5 0 0 5 5 5 1 TATA-binding protein interacting (TIP20) HEAT_2 PF13646.6 ETO22841.1 - 2e-14 53.8 5.3 4.4e-05 23.8 0.0 7.9 8 1 0 8 8 8 2 HEAT repeats Adaptin_N PF01602.20 ETO22841.1 - 1.2e-13 50.5 14.5 1.6e-06 27.0 3.1 5.7 4 1 1 5 5 5 2 Adaptin N terminal region HEAT_EZ PF13513.6 ETO22841.1 - 1.6e-13 50.8 10.7 1.2 9.7 0.0 11.5 14 0 0 14 14 12 2 HEAT-like repeat HEAT PF02985.22 ETO22841.1 - 3e-13 48.8 18.8 0.0023 18.0 0.0 12.7 14 0 0 14 14 14 2 HEAT repeat Cnd1 PF12717.7 ETO22841.1 - 1.9e-09 37.8 14.4 0.0012 18.9 0.0 7.3 6 2 3 9 9 9 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO22841.1 - 5.8e-08 33.2 7.3 0.004 17.7 0.0 8.5 8 2 4 12 12 11 1 Vacuolar 14 Fab1-binding region Tti2 PF10521.9 ETO22841.1 - 0.0055 16.3 5.1 0.23 11.0 0.0 5.4 6 1 0 6 6 6 1 Tti2 family UME PF08064.13 ETO22841.1 - 0.0075 16.2 0.3 17 5.4 0.0 5.4 6 0 0 6 6 6 0 UME (NUC010) domain TAF6_C PF07571.13 ETO22841.1 - 0.024 15.0 0.2 2.4 8.5 0.0 4.2 3 1 0 3 3 3 0 TAF6 C-terminal HEAT repeat domain Telomere_reg-2 PF10193.9 ETO22841.1 - 0.049 14.1 5.6 1.9 8.9 0.0 4.9 4 0 0 4 4 4 0 Telomere length regulation protein RIX1 PF08167.12 ETO22841.1 - 0.14 11.9 7.2 0.27 10.9 0.1 4.8 4 3 0 4 4 4 0 rRNA processing/ribosome biogenesis Arm PF00514.23 ETO22841.1 - 0.16 12.1 7.6 3.4 7.8 0.0 5.7 8 0 0 8 8 6 0 Armadillo/beta-catenin-like repeat V-ATPase_H_C PF11698.8 ETO22841.1 - 1.3 9.1 19.6 0.88 9.7 2.9 7.1 7 1 1 8 8 8 0 V-ATPase subunit H tRNA-synt_1e PF01406.19 ETO22842.1 - 3.7e-09 36.3 0.2 3.7e-09 36.3 0.2 1.9 2 0 0 2 2 2 1 tRNA synthetases class I (C) catalytic domain Pox_A51 PF04948.13 ETO22842.1 - 0.018 13.9 0.1 0.032 13.1 0.1 1.4 1 0 0 1 1 1 0 Poxvirus A51 protein KptA_kDCL PF18176.1 ETO22842.1 - 0.055 13.3 0.7 2.9 7.7 0.1 2.7 3 0 0 3 3 3 0 KptA in kinetoplastid DICER domain Matrilin_ccoil PF10393.9 ETO22842.1 - 0.11 12.4 0.1 0.47 10.4 0.1 2.1 1 0 0 1 1 1 0 Trimeric coiled-coil oligomerisation domain of matrilin BRE1 PF08647.11 ETO22842.1 - 0.69 10.0 22.9 1.6 8.9 5.9 4.3 4 0 0 4 4 4 0 BRE1 E3 ubiquitin ligase Bunya_RdRp PF04196.12 ETO22843.1 - 0.021 13.2 0.3 0.022 13.2 0.3 1.1 1 0 0 1 1 1 0 Bunyavirus RNA dependent RNA polymerase DUF1336 PF07059.12 ETO22844.1 - 7.5e-25 88.3 0.0 8.4e-25 88.2 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) Apis_Csd PF11671.8 ETO22844.1 - 0.0057 16.7 5.8 0.011 15.8 5.8 1.4 1 0 0 1 1 1 1 Complementary sex determiner protein FAM176 PF14851.6 ETO22844.1 - 0.22 11.2 5.5 1.6 8.4 0.9 2.7 3 0 0 3 3 3 0 FAM176 family DUF2956 PF11169.8 ETO22844.1 - 6.6 7.0 12.1 1.6 9.0 1.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) Peptidase_C54 PF03416.19 ETO22845.1 - 0.053 12.9 0.1 0.11 11.9 0.0 1.5 1 1 0 1 1 1 0 Peptidase family C54 DUF3530 PF12048.8 ETO22846.1 - 0.053 12.9 0.0 0.061 12.7 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) TPR_MLP1_2 PF07926.12 ETO22847.1 - 0.0081 16.2 11.1 0.0081 16.2 11.1 2.1 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein Golgin_A5 PF09787.9 ETO22847.1 - 0.14 11.6 17.7 0.18 11.2 17.7 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 KfrA_N PF11740.8 ETO22847.1 - 0.16 12.6 6.8 3.5 8.4 2.6 2.2 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term Exonuc_VII_L PF02601.15 ETO22847.1 - 0.32 10.5 7.0 0.4 10.2 7.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3450 PF11932.8 ETO22847.1 - 0.46 9.7 9.1 0.072 12.4 5.4 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Atg14 PF10186.9 ETO22847.1 - 0.78 8.8 13.5 0.55 9.3 12.2 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_GPO PF05929.11 ETO22847.1 - 0.96 9.0 8.7 0.68 9.5 7.5 1.4 1 1 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Cnn_1N PF07989.11 ETO22847.1 - 2.4 8.4 19.7 1.2 9.3 15.2 2.7 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 UPF0242 PF06785.11 ETO22847.1 - 2.5 8.2 18.2 4.5 7.3 18.2 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 ETO22847.1 - 2.8 8.0 6.4 1 9.4 3.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Uso1_p115_C PF04871.13 ETO22847.1 - 3.7 7.9 21.4 11 6.4 21.4 1.8 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Jnk-SapK_ap_N PF09744.9 ETO22847.1 - 4.4 7.5 19.4 7 6.9 19.4 1.3 1 1 0 1 1 1 0 JNK_SAPK-associated protein-1 DUF5320 PF17253.2 ETO22847.1 - 5.5 8.1 8.5 24 6.1 8.5 2.0 1 1 0 1 1 1 0 Family of unknown function (DUF5320) DUF4407 PF14362.6 ETO22847.1 - 9.8 5.4 10.2 13 5.0 10.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) XRN_M PF17846.1 ETO22848.1 - 0.055 12.4 8.6 0.06 12.3 8.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain Zip PF02535.22 ETO22848.1 - 3.7 6.7 5.6 5.4 6.1 5.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter AAA_lid_3 PF17862.1 ETO22849.1 - 4.8e-07 29.5 0.0 1.5e-06 27.9 0.0 1.8 2 0 0 2 2 2 1 AAA+ lid domain Vps4_C PF09336.10 ETO22849.1 - 0.0023 17.9 0.5 0.0045 17.0 0.2 1.7 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain RHH_4 PF13467.6 ETO22849.1 - 0.093 12.6 0.3 0.45 10.4 0.1 2.0 2 0 0 2 2 2 0 Ribbon-helix-helix domain Med12 PF09497.10 ETO22849.1 - 0.098 13.0 0.0 0.14 12.4 0.0 1.4 1 0 0 1 1 1 0 Transcription mediator complex subunit Med12 AIRS_C PF02769.22 ETO22849.1 - 0.15 12.2 0.0 0.19 11.8 0.0 1.2 1 0 0 1 1 1 0 AIR synthase related protein, C-terminal domain SAM_PNT PF02198.16 ETO22850.1 - 3.8e-08 33.2 0.1 6.2e-08 32.5 0.1 1.3 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 ETO22850.1 - 0.00011 22.3 0.2 0.00027 21.0 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO22850.1 - 0.00084 19.7 1.0 0.0024 18.3 1.0 1.8 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) Peptidase_A17 PF05380.13 ETO22851.1 - 0.11 12.5 1.5 0.15 12.0 0.2 1.7 2 0 0 2 2 2 0 Pao retrotransposon peptidase Secretin_N_2 PF07655.13 ETO22852.1 - 0.54 10.8 7.0 1.4 9.5 7.0 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain Apis_Csd PF11671.8 ETO22852.1 - 3.2 7.7 10.1 9.5 6.2 10.1 1.9 1 0 0 1 1 1 0 Complementary sex determiner protein Tubulin PF00091.25 ETO22853.1 - 7.2e-44 150.3 0.0 1.1e-43 149.7 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO22853.1 - 7.9e-23 81.0 0.1 4.9e-21 75.2 0.1 2.4 1 1 0 1 1 1 1 Tubulin C-terminal domain XOO_2897-deam PF14440.6 ETO22854.1 - 0.047 13.8 0.1 0.087 12.9 0.1 1.5 1 0 0 1 1 1 0 Xanthomonas XOO_2897-like deaminase Helicase_C PF00271.31 ETO22856.1 - 0.00081 19.7 0.0 0.0015 18.9 0.0 1.4 1 0 0 1 1 1 1 Helicase conserved C-terminal domain XH PF03469.14 ETO22857.1 - 0.069 13.1 0.2 0.9 9.5 0.0 2.1 2 0 0 2 2 2 0 XH domain Suv3_C_1 PF18147.1 ETO22858.1 - 2.3e-12 46.6 0.1 4.5e-12 45.6 0.1 1.5 1 0 0 1 1 1 1 Suv3 C-terminal domain 1 SUV3_C PF12513.8 ETO22858.1 - 0.00034 20.5 0.0 0.00065 19.6 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial degradasome RNA helicase subunit C terminal WD40 PF00400.32 ETO22859.1 - 1.3e-05 25.9 1.9 0.015 16.2 0.2 2.5 2 1 0 2 2 2 2 WD domain, G-beta repeat CRT10 PF08728.10 ETO22859.1 - 0.0032 15.7 0.2 0.0037 15.5 0.2 1.0 1 0 0 1 1 1 1 CRT10 Tctex-1 PF03645.13 ETO22860.1 - 1.6e-15 57.2 1.4 2.9e-15 56.4 0.9 1.6 1 1 1 2 2 2 1 Tctex-1 family Sec66 PF09802.9 ETO22860.1 - 0.056 13.0 0.1 0.074 12.6 0.1 1.2 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DUF1902 PF08972.11 ETO22860.1 - 0.077 13.0 0.0 0.12 12.4 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1902) PI3K_rbd PF00794.18 ETO22860.1 - 0.084 13.0 0.1 0.19 11.9 0.0 1.5 2 0 0 2 2 2 0 PI3-kinase family, ras-binding domain Adaptin_N PF01602.20 ETO22860.1 - 0.092 11.3 0.0 0.11 11.0 0.0 1.0 1 0 0 1 1 1 0 Adaptin N terminal region ThiF PF00899.21 ETO22861.1 - 2.5e-49 167.8 0.5 6.6e-36 123.9 0.0 2.0 2 0 0 2 2 2 2 ThiF family NAD_binding_7 PF13241.6 ETO22861.1 - 0.00029 21.2 0.1 0.0012 19.3 0.1 1.8 1 1 0 1 1 1 1 Putative NAD(P)-binding Shikimate_DH PF01488.20 ETO22861.1 - 0.00033 20.7 0.1 0.00075 19.6 0.1 1.5 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase Sacchrp_dh_NADP PF03435.18 ETO22861.1 - 0.023 15.0 0.0 0.45 10.8 0.0 2.2 2 0 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain Ldh_1_N PF00056.23 ETO22861.1 - 0.044 13.9 0.3 0.08 13.0 0.3 1.5 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain UBA_e1_thiolCys PF10585.9 ETO22861.1 - 0.075 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Ubiquitin-activating enzyme active site WD40 PF00400.32 ETO22862.1 - 1e-18 67.3 16.2 1.4e-08 35.2 1.0 5.4 6 0 0 6 6 6 3 WD domain, G-beta repeat Katanin_con80 PF13925.6 ETO22862.1 - 1.3e-12 48.1 2.4 3.2e-12 46.8 2.4 1.7 1 0 0 1 1 1 1 con80 domain of Katanin ANAPC4_WD40 PF12894.7 ETO22862.1 - 2.8e-08 33.9 2.5 0.00094 19.4 0.0 4.0 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain SIT PF15330.6 ETO22862.1 - 0.58 10.6 4.3 25 5.4 0.0 3.8 3 1 1 4 4 4 0 SHP2-interacting transmembrane adaptor protein, SIT DUF4217 PF13959.6 ETO22863.1 - 2.3e-16 59.8 0.1 5.8e-16 58.5 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4217) Helicase_C PF00271.31 ETO22863.1 - 3.2e-12 46.8 0.9 7.7e-12 45.5 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Pet100 PF09803.9 ETO22863.1 - 0.11 13.1 3.1 0.11 13.0 1.9 1.6 1 1 0 1 1 1 0 Pet100 HisKA_7TM PF16927.5 ETO22864.1 - 0.00079 19.5 4.9 0.0013 18.8 4.9 1.5 1 1 0 1 1 1 1 N-terminal 7TM region of histidine kinase DUF3611 PF12263.8 ETO22864.1 - 0.012 15.5 0.7 0.012 15.5 0.7 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3611) DUF4199 PF13858.6 ETO22864.1 - 0.26 11.7 2.5 1.6 9.1 2.4 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) HAP2-GCS1 PF10699.9 ETO22865.1 - 2.7e-19 68.9 0.1 5.4e-19 67.9 0.1 1.5 1 0 0 1 1 1 1 Male gamete fusion factor TTC5_OB PF16669.5 ETO22866.1 - 0.077 12.7 0.1 0.11 12.2 0.1 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat protein 5 OB fold domain Ribosomal_S18 PF01084.20 ETO22867.1 - 1.6e-16 60.2 2.6 2.1e-16 59.8 0.1 2.4 3 0 0 3 3 3 1 Ribosomal protein S18 EF-hand_6 PF13405.6 ETO22868.1 - 1.9e-10 39.8 3.1 7.8e-06 25.4 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO22868.1 - 1.3e-09 36.9 4.8 6.3e-06 25.4 0.4 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO22868.1 - 2.6e-07 31.0 6.9 0.0082 16.6 0.2 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO22868.1 - 4.7e-05 22.7 4.4 0.00031 20.1 0.3 3.0 2 1 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO22868.1 - 9.3e-05 22.2 8.7 0.00074 19.3 2.2 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_9 PF14658.6 ETO22868.1 - 0.033 14.5 1.9 2.8 8.3 0.3 3.1 2 1 1 3 3 3 0 EF-hand domain Mei5_like PF17021.5 ETO22868.1 - 0.047 13.7 0.7 0.047 13.7 0.7 2.6 1 1 1 2 2 2 0 Putative double-strand recombination repair-like FlaC_arch PF05377.11 ETO22868.1 - 0.22 11.9 4.0 0.19 12.2 1.6 2.3 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) SPARC_Ca_bdg PF10591.9 ETO22868.1 - 0.39 11.1 5.1 0.11 12.8 0.5 2.1 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF5320 PF17253.2 ETO22868.1 - 1.1 10.4 3.1 2.1 9.5 2.9 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5320) Pkinase PF00069.25 ETO22869.1 - 1e-08 34.9 0.2 1.4e-08 34.5 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22869.1 - 0.0031 16.8 0.2 0.0044 16.3 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UCH PF00443.29 ETO22870.1 - 6e-08 32.5 0.0 6e-08 32.5 0.0 3.5 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase TLD PF07534.16 ETO22871.1 - 4.2e-11 43.2 5.9 1.3e-10 41.6 5.9 1.8 1 1 0 1 1 1 1 TLD Pur_ac_phosph_N PF16656.5 ETO22871.1 - 2.2 8.9 5.6 0.25 12.0 0.3 2.2 2 0 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain Presenilin PF01080.17 ETO22871.1 - 7.4 5.2 29.9 0.32 9.7 10.2 2.9 3 0 0 3 3 3 0 Presenilin CLPTM1 PF05602.12 ETO22872.1 - 0.044 12.8 1.5 0.073 12.1 1.5 1.3 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) Peptidase_M16_C PF05193.21 ETO22873.1 - 5.9e-06 26.4 0.1 1.7e-05 24.9 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain Peptidase_M16_M PF16187.5 ETO22874.1 - 8.8e-29 100.7 7.4 4.3e-27 95.1 7.4 2.8 1 1 0 1 1 1 1 Middle or third domain of peptidase_M16 Tweety PF04906.13 ETO22874.1 - 0.025 13.3 0.7 0.05 12.3 0.7 1.5 1 0 0 1 1 1 0 Tweety Orthoreo_P10 PF07204.11 ETO22874.1 - 0.069 13.1 0.2 0.18 11.8 0.2 1.7 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 FAT PF02259.23 ETO22875.1 - 0.00018 20.9 0.2 0.00026 20.3 0.2 1.3 1 1 0 1 1 1 1 FAT domain RcpC PF16976.5 ETO22875.1 - 0.011 15.8 0.3 0.017 15.2 0.3 1.3 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB LuxT_C PF18285.1 ETO22875.1 - 0.021 15.3 0.0 0.039 14.5 0.0 1.4 1 0 0 1 1 1 0 Tetracycline repressor LuxT C-terminal domain FolB PF02152.18 ETO22875.1 - 0.028 14.9 0.0 0.05 14.2 0.0 1.3 1 0 0 1 1 1 0 Dihydroneopterin aldolase TPR_19 PF14559.6 ETO22875.1 - 0.097 13.2 0.0 0.34 11.5 0.0 1.9 1 1 1 2 2 2 0 Tetratricopeptide repeat Secretin_N_2 PF07655.13 ETO22876.1 - 0.0055 17.2 5.0 0.0091 16.5 5.0 1.4 1 0 0 1 1 1 1 Secretin N-terminal domain Phage_holin_3_6 PF07332.11 ETO22876.1 - 0.14 12.2 0.1 0.19 11.8 0.1 1.1 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Peroxin-13_N PF04088.13 ETO22876.1 - 0.24 11.7 1.3 2 8.7 1.3 2.0 1 1 0 1 1 1 0 Peroxin 13, N-terminal region Methyltransf_23 PF13489.6 ETO22877.1 - 9.3e-22 77.6 0.0 1.4e-21 77.1 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO22877.1 - 2.1e-18 66.7 0.0 4.8e-18 65.6 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO22877.1 - 1.5e-17 64.1 0.0 3.1e-17 63.1 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO22877.1 - 8.1e-15 54.9 0.0 1.2e-14 54.4 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO22877.1 - 1.3e-14 54.1 0.0 2.1e-14 53.4 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ETO22877.1 - 1.1e-11 45.3 0.0 1.8e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ETO22877.1 - 0.00025 20.7 0.0 0.00044 19.9 0.0 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW TehB PF03848.14 ETO22877.1 - 0.0012 18.3 0.0 0.002 17.6 0.0 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB GCP_C_terminal PF04130.13 ETO22879.1 - 4.8e-18 65.7 6.6 6.2e-18 65.3 6.6 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ETO22880.1 - 1.9e-19 70.4 1.4 4.8e-19 69.1 1.4 1.6 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal G-gamma PF00631.22 ETO22881.1 - 0.0018 18.3 0.4 0.0031 17.5 0.4 1.4 1 0 0 1 1 1 1 GGL domain DivIC PF04977.15 ETO22881.1 - 0.0019 17.9 0.7 0.0035 17.1 0.7 1.5 1 0 0 1 1 1 1 Septum formation initiator APA3_viroporin PF11289.8 ETO22882.1 - 4.3 6.8 12.9 6.7 6.2 12.9 1.3 1 0 0 1 1 1 0 Coronavirus accessory protein 3a BID PF06393.11 ETO22884.1 - 0.0071 15.9 1.0 0.0097 15.5 0.9 1.3 1 1 0 1 1 1 1 BH3 interacting domain (BID) ATG16 PF08614.11 ETO22885.1 - 8.3e-05 22.9 7.9 8.3e-05 22.9 7.9 2.1 1 1 1 2 2 2 1 Autophagy protein 16 (ATG16) CENP-F_leu_zip PF10473.9 ETO22885.1 - 0.00017 21.7 23.2 0.015 15.3 5.8 2.4 1 1 1 2 2 2 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG6_N PF17675.1 ETO22885.1 - 0.0002 21.9 24.3 0.013 16.0 7.4 2.1 1 1 1 2 2 2 2 Apg6 coiled-coil region GAS PF13851.6 ETO22885.1 - 0.00063 19.1 25.4 0.0011 18.4 17.5 2.1 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding DUF4201 PF13870.6 ETO22885.1 - 0.0012 18.6 12.9 0.0012 18.6 12.9 2.3 1 1 0 2 2 2 1 Domain of unknown function (DUF4201) DUF5082 PF16888.5 ETO22885.1 - 0.0018 18.6 16.1 0.039 14.2 6.5 2.2 1 1 1 2 2 2 2 Domain of unknown function (DUF5082) Spc7 PF08317.11 ETO22885.1 - 0.0021 17.0 22.2 0.0065 15.4 22.2 1.6 1 1 0 1 1 1 1 Spc7 kinetochore protein DUF2968 PF11180.8 ETO22885.1 - 0.0024 17.5 1.8 0.0024 17.5 1.8 2.3 2 1 0 2 2 2 1 Protein of unknown function (DUF2968) bZIP_1 PF00170.21 ETO22885.1 - 0.0028 17.7 19.3 0.017 15.2 2.6 3.4 1 1 1 3 3 3 2 bZIP transcription factor TMF_TATA_bd PF12325.8 ETO22885.1 - 0.0041 17.3 22.3 0.079 13.2 4.6 2.2 1 1 1 2 2 2 2 TATA element modulatory factor 1 TATA binding BLOC1_2 PF10046.9 ETO22885.1 - 0.0056 16.9 20.5 0.13 12.6 5.6 2.3 2 0 0 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 TPR_MLP1_2 PF07926.12 ETO22885.1 - 0.0065 16.5 16.7 0.0065 16.5 16.7 2.1 1 1 1 2 2 2 1 TPR/MLP1/MLP2-like protein Spectrin PF00435.21 ETO22885.1 - 0.0075 16.7 16.9 0.015 15.8 8.5 2.3 1 1 1 2 2 2 1 Spectrin repeat DivIC PF04977.15 ETO22885.1 - 0.0083 15.9 17.9 0.11 12.3 2.0 3.0 2 1 1 3 3 3 2 Septum formation initiator Fez1 PF06818.15 ETO22885.1 - 0.02 15.3 21.8 0.21 12.0 22.1 1.9 1 1 0 1 1 1 0 Fez1 Syntaxin PF00804.25 ETO22885.1 - 0.022 14.5 15.8 0.044 13.4 5.6 2.2 1 1 1 2 2 2 0 Syntaxin YabA PF06156.13 ETO22885.1 - 0.029 15.0 18.7 0.13 13.0 7.1 2.3 1 1 1 2 2 2 0 Initiation control protein YabA JIP_LZII PF16471.5 ETO22885.1 - 0.035 14.3 17.2 1.1 9.5 0.3 3.9 2 2 1 3 3 3 0 JNK-interacting protein leucine zipper II CLZ PF16526.5 ETO22885.1 - 0.042 14.2 20.0 1.7 9.1 1.2 3.4 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels NRBF2 PF08961.10 ETO22885.1 - 0.069 12.7 16.4 0.14 11.7 8.8 2.1 1 1 1 2 2 2 0 Nuclear receptor-binding factor 2, autophagy regulator DUF4407 PF14362.6 ETO22885.1 - 0.076 12.4 6.9 0.13 11.6 6.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4795 PF16043.5 ETO22885.1 - 0.081 12.5 21.9 1 8.9 2.4 2.3 1 1 0 2 2 2 0 Domain of unknown function (DUF4795) ADIP PF11559.8 ETO22885.1 - 0.14 12.2 26.3 1 9.4 10.8 2.2 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding WXG100 PF06013.12 ETO22885.1 - 0.15 12.3 9.5 4.1 7.7 0.0 3.1 3 1 0 3 3 2 0 Proteins of 100 residues with WXG GABP-alpha PF11620.8 ETO22885.1 - 0.17 12.1 6.2 0.34 11.1 6.2 1.5 1 0 0 1 1 1 0 GA-binding protein alpha chain ZapB PF06005.12 ETO22885.1 - 0.18 12.2 26.3 2.9 8.4 8.7 3.4 1 1 1 2 2 1 0 Cell division protein ZapB FlaC_arch PF05377.11 ETO22885.1 - 0.28 11.6 11.6 3.4 8.1 0.2 3.5 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF2730 PF10805.8 ETO22885.1 - 0.31 11.2 9.8 4 7.6 0.2 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF2730) DUF3450 PF11932.8 ETO22885.1 - 0.37 10.1 21.2 0.73 9.1 2.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Jnk-SapK_ap_N PF09744.9 ETO22885.1 - 0.51 10.6 25.3 7.4 6.8 11.8 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Herpes_BLRF2 PF05812.12 ETO22885.1 - 0.57 10.3 8.2 3.3 7.9 2.0 2.5 2 1 0 2 2 2 0 Herpesvirus BLRF2 protein CENP-K PF11802.8 ETO22885.1 - 0.59 9.7 19.2 0.79 9.2 19.2 1.1 1 0 0 1 1 1 0 Centromere-associated protein K Seryl_tRNA_N PF02403.22 ETO22885.1 - 0.67 10.2 17.2 8.3 6.7 0.8 2.7 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 ETO22885.1 - 0.87 8.6 18.7 0.52 9.3 2.9 2.0 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Spc42p PF11544.8 ETO22885.1 - 1.4 8.9 14.9 0.7 9.9 3.5 2.6 2 1 0 2 2 2 0 Spindle pole body component Spc42p CtIP_N PF10482.9 ETO22885.1 - 1.4 9.0 18.3 2.4 8.2 17.9 1.6 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain Leu_zip PF15294.6 ETO22885.1 - 1.5 8.3 21.6 8.8 5.7 21.2 1.8 1 1 0 1 1 1 0 Leucine zipper BRE1 PF08647.11 ETO22885.1 - 1.8 8.7 24.1 5.8 7.1 7.1 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF1664 PF07889.12 ETO22885.1 - 1.9 8.5 12.7 10 6.2 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2205 PF10224.9 ETO22885.1 - 2 8.5 19.0 4.5 7.3 0.6 3.4 1 1 1 3 3 3 0 Short coiled-coil protein FapA PF03961.13 ETO22885.1 - 2.1 6.9 15.9 0.92 8.0 3.1 2.0 1 1 1 2 2 2 0 Flagellar Assembly Protein A ERM PF00769.19 ETO22885.1 - 2.3 8.0 22.7 4.5 7.0 4.2 2.1 1 1 0 2 2 2 0 Ezrin/radixin/moesin family Syntaxin-6_N PF09177.11 ETO22885.1 - 2.4 8.7 11.9 6.9 7.3 4.5 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Tropomyosin_1 PF12718.7 ETO22885.1 - 2.7 8.1 18.6 9 6.5 17.9 1.9 1 1 0 1 1 1 0 Tropomyosin like DUF948 PF06103.11 ETO22885.1 - 2.8 8.3 9.2 5.6e+02 0.9 9.2 3.0 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.15 ETO22885.1 - 3.1 7.7 20.5 4.9 7.0 2.4 2.2 1 1 1 2 2 2 0 Sec34-like family UPF0242 PF06785.11 ETO22885.1 - 4 7.5 23.6 93 3.0 23.6 2.1 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Occludin_ELL PF07303.13 ETO22885.1 - 4.1 8.2 16.6 7.9 7.3 8.5 2.3 1 1 1 2 2 2 0 Occludin homology domain Sec8_exocyst PF04048.14 ETO22885.1 - 4.9 7.0 17.8 2.4 8.0 9.5 2.3 1 1 1 2 2 2 0 Sec8 exocyst complex component specific domain Nup54 PF13874.6 ETO22885.1 - 5.2 7.2 18.9 3.6 7.7 5.0 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 TolA_bind_tri PF16331.5 ETO22885.1 - 5.3 7.2 21.8 5.2 7.2 0.3 3.1 1 1 1 3 3 3 0 TolA binding protein trimerisation DUF5595 PF18077.1 ETO22885.1 - 5.5 7.1 14.8 1.7 8.8 0.7 3.8 2 2 2 4 4 4 0 Domain of unknown function (DUF5595) DUF4404 PF14357.6 ETO22885.1 - 5.7 7.7 17.7 9.3 7.0 6.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) TMPIT PF07851.13 ETO22885.1 - 7.7 5.7 19.3 8 5.6 10.6 2.1 1 1 1 2 2 2 0 TMPIT-like protein KELK PF15796.5 ETO22885.1 - 8.2 7.0 17.9 3.4 8.2 7.7 2.9 1 1 2 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase FlxA PF14282.6 ETO22885.1 - 8.3 6.5 28.2 5.8 7.0 0.3 3.2 1 1 1 3 3 3 0 FlxA-like protein DUF16 PF01519.16 ETO22885.1 - 9 6.9 17.2 1 9.9 1.5 2.2 1 1 0 2 2 2 0 Protein of unknown function DUF16 ATG11 PF10377.9 ETO22886.1 - 0.00073 19.6 0.0 0.0017 18.4 0.0 1.5 2 0 0 2 2 2 1 Autophagy-related protein 11 Las1 PF04031.13 ETO22887.1 - 6.9e-29 100.9 4.6 2.4e-28 99.2 2.8 2.4 2 0 0 2 2 2 1 Las1-like Pentapeptide_4 PF13599.6 ETO22887.1 - 7.1 6.9 9.8 8.6 6.6 5.6 3.0 3 0 0 3 3 3 0 Pentapeptide repeats (9 copies) Swm2 PF17083.5 ETO22888.1 - 0.073 13.1 1.6 1.4 8.9 0.1 2.4 2 0 0 2 2 2 0 Nucleolar protein Swm2 Med26 PF08711.11 ETO22889.1 - 1.1e-10 41.3 1.3 1.1e-10 41.3 1.3 2.1 2 0 0 2 2 2 1 TFIIS helical bundle-like domain IF2_N PF04760.15 ETO22889.1 - 0.033 14.0 0.8 0.21 11.5 0.1 2.5 2 0 0 2 2 2 0 Translation initiation factor IF-2, N-terminal region Med3 PF11593.8 ETO22889.1 - 0.091 11.9 26.2 0.23 10.6 26.2 1.6 1 1 0 1 1 1 0 Mediator complex subunit 3 fungal SAP130_C PF16014.5 ETO22889.1 - 0.1 11.7 11.7 0.13 11.3 11.7 1.2 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus DUF3713 PF12506.8 ETO22889.1 - 1.9 8.8 13.3 0.4 11.0 8.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3713) NUDE_C PF04880.13 ETO22889.1 - 4.2 7.8 11.3 6.4 7.2 11.3 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region YfhO PF09586.10 ETO22890.1 - 0.51 8.5 11.0 0.076 11.2 6.2 1.7 1 1 1 2 2 2 0 Bacterial membrane protein YfhO DUF2631 PF10939.8 ETO22890.1 - 0.77 9.6 3.1 5.2 7.0 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2631) G-alpha PF00503.20 ETO22891.1 - 7.1e-46 157.0 13.4 5.4e-45 154.1 13.4 2.0 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO22891.1 - 0.0002 20.8 0.7 0.028 13.9 0.1 2.7 2 1 0 2 2 2 2 ADP-ribosylation factor family RET_CLD1 PF17756.1 ETO22892.1 - 0.00085 19.6 0.0 0.0021 18.3 0.0 1.6 1 0 0 1 1 1 1 RET Cadherin like domain 1 Seipin PF06775.14 ETO22893.1 - 0.064 13.3 0.0 0.077 13.1 0.0 1.1 1 0 0 1 1 1 0 Putative adipose-regulatory protein (Seipin) Sec63 PF02889.16 ETO22893.1 - 0.09 11.9 2.2 0.13 11.4 2.2 1.4 1 1 0 1 1 1 0 Sec63 Brl domain TPD52 PF04201.15 ETO22893.1 - 1.3 8.6 10.2 0.29 10.7 0.9 2.2 1 1 0 2 2 2 0 Tumour protein D52 family PRP1_N PF06424.12 ETO22893.1 - 3.9 7.9 6.9 0.46 10.9 2.5 1.6 2 0 0 2 2 2 0 PRP1 splicing factor, N-terminal DUF4181 PF13789.6 ETO22894.1 - 0.014 15.6 2.3 0.1 12.9 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4181) MASE5 PF17178.4 ETO22894.1 - 0.058 13.2 0.1 0.094 12.5 0.1 1.2 1 0 0 1 1 1 0 Membrane-associated sensor DUF2542 PF10808.8 ETO22894.1 - 0.14 12.6 1.4 17 6.0 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF2542) YlbE PF14003.6 ETO22895.1 - 0.053 14.0 0.4 0.15 12.5 0.4 1.8 1 0 0 1 1 1 0 YlbE-like protein PUB PF09409.10 ETO22895.1 - 0.083 12.8 3.8 0.41 10.6 3.8 2.1 1 1 0 1 1 1 0 PUB domain Big_11 PF18200.1 ETO22895.1 - 0.084 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain C5HCH PF17982.1 ETO22896.1 - 0.012 15.7 4.9 0.31 11.2 0.9 2.7 2 0 0 2 2 2 0 NSD Cys-His rich domain NT-C2 PF10358.9 ETO22897.1 - 5.7e-05 22.9 0.0 0.00011 21.9 0.0 1.5 1 1 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Phage-scaffold PF09306.10 ETO22897.1 - 0.057 12.8 0.1 0.07 12.5 0.1 1.1 1 0 0 1 1 1 0 Bacteriophage, scaffolding protein Trp_dioxygenase PF03301.13 ETO22897.1 - 0.072 12.4 0.1 0.082 12.2 0.1 1.0 1 0 0 1 1 1 0 Tryptophan 2,3-dioxygenase VPS9 PF02204.18 ETO22898.1 - 2.2e-10 40.7 0.3 4.8e-10 39.6 0.1 1.7 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain CENP-M PF11111.8 ETO22900.1 - 0.046 12.9 1.6 0.11 11.7 1.6 1.5 1 0 0 1 1 1 0 Centromere protein M (CENP-M) ABC-3 PF00950.17 ETO22901.1 - 0.013 15.0 0.5 0.016 14.7 0.5 1.2 1 0 0 1 1 1 0 ABC 3 transport family Dynein_AAA_lid PF17852.1 ETO22901.1 - 0.11 12.6 1.3 0.26 11.4 0.3 2.1 1 1 1 2 2 2 0 Dynein heavy chain AAA lid domain RGS PF00615.19 ETO22903.1 - 1.1e-05 25.7 0.7 2e-05 24.8 0.7 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Pkinase PF00069.25 ETO22904.1 - 1.8e-19 70.2 7.1 7.6e-19 68.1 7.1 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22904.1 - 6.2e-16 58.4 2.3 1.3e-15 57.4 2.3 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ETO22904.1 - 0.0062 16.2 0.3 0.014 15.0 0.3 1.6 1 0 0 1 1 1 1 RIO1 family FBA PF04300.13 ETO22904.1 - 0.0067 16.1 0.6 0.011 15.4 0.6 1.3 1 0 0 1 1 1 1 F-box associated region Pkinase_fungal PF17667.1 ETO22904.1 - 0.028 13.2 0.3 0.039 12.7 0.2 1.3 1 1 0 1 1 1 0 Fungal protein kinase Phage_int_SAM_5 PF13102.6 ETO22904.1 - 0.28 11.5 3.9 2.4 8.5 0.5 2.9 2 1 1 3 3 3 0 Phage integrase SAM-like domain Borrelia_P83 PF05262.11 ETO22906.1 - 7.3e-05 21.5 35.0 7.3e-05 21.5 35.0 2.2 1 1 1 2 2 2 1 Borrelia P83/100 protein TSC22 PF01166.18 ETO22907.1 - 5.4e-05 23.4 13.1 0.001 19.3 0.5 3.2 3 0 0 3 3 3 2 TSC-22/dip/bun family LemA PF04011.12 ETO22907.1 - 0.0093 15.8 1.6 0.0093 15.8 1.6 1.6 2 0 0 2 2 2 1 LemA family GIT_CC PF16559.5 ETO22907.1 - 0.17 11.8 16.7 1.5 8.7 0.5 3.3 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor SOGA PF11365.8 ETO22907.1 - 0.26 12.4 14.1 0.57 11.3 8.0 2.2 1 1 1 2 2 2 0 Protein SOGA DivIC PF04977.15 ETO22907.1 - 0.44 10.4 16.2 0.62 9.9 3.7 3.2 3 0 0 3 3 3 0 Septum formation initiator Vpu PF00558.19 ETO22907.1 - 0.61 9.9 6.3 0.43 10.4 3.2 2.2 1 1 1 2 2 2 0 Vpu protein DUF4315 PF14193.6 ETO22907.1 - 1 9.4 15.7 0.78 9.8 0.2 3.3 3 1 0 3 3 3 0 Domain of unknown function (DUF4315) AAA_13 PF13166.6 ETO22907.1 - 1.1 7.8 14.7 0.32 9.6 8.2 1.9 1 1 1 2 2 2 0 AAA domain DUF724 PF05266.14 ETO22907.1 - 5.7 6.7 21.9 5.3 6.8 1.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) 14-3-3 PF00244.20 ETO22908.1 - 7.6e-10 38.7 9.1 2.7e-07 30.3 2.5 2.2 2 0 0 2 2 2 2 14-3-3 protein NOA36 PF06524.12 ETO22908.1 - 0.0091 15.4 3.2 0.011 15.1 3.2 1.3 1 0 0 1 1 1 1 NOA36 protein PH_6 PF15406.6 ETO22908.1 - 0.013 15.7 0.7 0.057 13.7 0.0 2.3 3 0 0 3 3 3 0 Pleckstrin homology domain Dna2 PF08696.11 ETO22908.1 - 0.02 14.7 5.5 0.044 13.6 5.5 1.7 1 1 0 1 1 1 0 DNA replication factor Dna2 CENP-B_dimeris PF09026.10 ETO22908.1 - 0.038 14.4 1.6 0.091 13.2 1.3 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF2785 PF10978.8 ETO22908.1 - 0.1 12.4 3.2 0.56 10.0 0.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2785) ETRAMP PF09716.10 ETO22910.1 - 0.00044 20.3 0.5 0.0014 18.7 0.3 1.9 1 1 0 1 1 1 1 Malarial early transcribed membrane protein (ETRAMP) DUF1987 PF09345.10 ETO22910.1 - 0.012 15.2 0.2 0.02 14.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1987) CRA PF06589.11 ETO22910.1 - 0.052 13.7 6.7 0.078 13.1 0.4 2.5 2 1 0 2 2 2 0 Circumsporozoite-related antigen (CRA) RXLR PF16810.5 ETO22910.1 - 0.1 13.0 2.5 1.1 9.7 0.1 2.3 2 0 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity Asp5 PF17000.5 ETO22910.1 - 0.11 12.6 0.2 1.1 9.4 0.0 2.3 3 0 0 3 3 3 0 Accessory secretory protein Sec, Asp5 DUF4381 PF14316.6 ETO22910.1 - 0.15 12.3 0.2 0.25 11.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Peptidase_C50 PF03568.17 ETO22911.1 - 1.9e-54 185.3 5.6 7.2e-53 180.1 5.6 2.7 1 1 0 1 1 1 1 Peptidase family C50 TPR_12 PF13424.6 ETO22911.1 - 0.0019 18.4 0.2 1.9 8.9 0.0 3.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO22912.1 - 0.0066 17.0 0.1 0.13 13.0 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_4 PF07721.14 ETO22912.1 - 0.097 13.3 0.0 0.27 12.0 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22912.1 - 0.099 12.9 0.9 1.2 9.5 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Gti1_Pac2 PF09729.9 ETO22912.1 - 2.2 8.3 6.6 1.5 8.9 0.3 2.9 3 0 0 3 3 3 0 Gti1/Pac2 family A_deaminase PF00962.22 ETO22913.1 - 1.7e-12 47.3 0.9 2.2e-12 46.9 0.4 1.4 2 0 0 2 2 2 1 Adenosine/AMP deaminase DUF3794 PF12673.7 ETO22914.1 - 0.025 14.9 0.1 0.044 14.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3794) Kelch_6 PF13964.6 ETO22914.1 - 0.027 14.7 0.0 0.25 11.7 0.0 2.7 2 0 0 2 2 2 0 Kelch motif DUF489 PF04356.12 ETO22914.1 - 0.066 13.2 0.1 0.09 12.8 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF489) SURF2 PF05477.11 ETO22915.1 - 1.7 8.3 37.4 1.9 8.1 37.4 1.0 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) SDA1 PF05285.12 ETO22915.1 - 2.3 7.6 58.1 2.5 7.4 58.1 1.1 1 0 0 1 1 1 0 SDA1 Skp1 PF01466.19 ETO22916.1 - 3.5e-08 33.4 0.0 1.3e-07 31.6 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETO22916.1 - 9.4e-05 22.5 1.8 0.00066 19.8 0.0 2.6 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain DUF4229 PF14012.6 ETO22917.1 - 0.037 14.1 3.4 0.037 14.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) DUF775 PF05603.12 ETO22917.1 - 0.27 10.8 6.7 0.042 13.4 2.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF775) GWT1 PF06423.12 ETO22917.1 - 0.34 11.0 12.5 0.14 12.3 5.0 2.3 1 1 0 2 2 2 0 GWT1 DUF1394 PF07159.12 ETO22918.1 - 3.2e-13 49.6 1.4 3.3e-12 46.3 1.4 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1394) Vps54_N PF10475.9 ETO22919.1 - 1.2e-17 64.2 13.9 1.4e-16 60.7 13.9 2.1 1 1 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex Secretin_N_2 PF07655.13 ETO22919.1 - 0.28 11.8 14.8 0.18 12.4 12.5 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain CENP-B_dimeris PF09026.10 ETO22919.1 - 1.5 9.2 5.1 0.39 11.1 1.1 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain GNAT_acetyltr_2 PF13718.6 ETO22919.1 - 3 7.2 10.0 2.3 7.6 0.5 2.3 1 1 1 2 2 2 0 GNAT acetyltransferase 2 FAM176 PF14851.6 ETO22919.1 - 7.4 6.2 13.3 2.9 7.5 0.8 2.3 1 1 1 2 2 2 0 FAM176 family FA_hydroxylase PF04116.13 ETO22920.1 - 3.2e-13 50.2 21.1 3.1e-11 43.7 17.9 2.6 2 1 0 2 2 2 1 Fatty acid hydroxylase superfamily Sigma70_ner PF04546.13 ETO22921.1 - 0.082 12.8 13.1 0.052 13.4 11.1 1.7 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.14 ETO22921.1 - 2.1 6.6 16.1 3.3 5.9 16.1 1.2 1 0 0 1 1 1 0 CDC45-like protein TP53IP5 PF15331.6 ETO22921.1 - 3.9 7.6 7.2 79 3.3 6.9 2.2 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 Pex14_N PF04695.13 ETO22921.1 - 5 7.8 9.0 7.6 7.2 3.9 2.4 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CENP-B_dimeris PF09026.10 ETO22921.1 - 6 7.3 13.2 1.9e+02 2.5 13.1 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ATP-synt_C PF00137.21 ETO22924.1 - 1.4e-27 95.8 36.1 6.3e-20 71.3 15.0 2.8 3 0 0 3 3 3 2 ATP synthase subunit C AcrZ PF10766.9 ETO22924.1 - 7.7 6.2 9.8 1.5 8.5 5.4 2.2 2 0 0 2 2 2 0 Multidrug efflux pump-associated protein AcrZ Pox_G9-A16 PF03003.16 ETO22925.1 - 0.014 15.1 1.6 0.014 15.1 1.6 2.2 2 0 0 2 2 2 0 Pox virus entry-fusion-complex G9/A16 Cpta_toxin PF07254.12 ETO22925.1 - 0.49 10.4 4.7 0.2 11.7 0.9 2.3 2 0 0 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system NACHT PF05729.12 ETO22926.1 - 5.8e-08 32.8 0.0 8.8e-08 32.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Rrn6 PF10214.9 ETO22926.1 - 0.024 13.2 0.7 0.034 12.7 0.7 1.5 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Serglycin PF04360.12 ETO22927.1 - 0.0047 16.9 1.3 0.008 16.1 1.3 1.3 1 0 0 1 1 1 1 Serglycin GlcNAc PF11397.8 ETO22928.1 - 1.8e-35 123.0 0.1 2.1e-35 122.8 0.1 1.0 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) Glyco_trans_2_3 PF13632.6 ETO22928.1 - 0.02 14.8 0.0 0.027 14.4 0.0 1.2 1 0 0 1 1 1 0 Glycosyl transferase family group 2 FliD_N PF02465.18 ETO22929.1 - 0.0056 17.4 3.0 0.0087 16.7 3.0 1.3 1 0 0 1 1 1 1 Flagellar hook-associated protein 2 N-terminus DUF1788 PF08747.11 ETO22929.1 - 0.019 15.0 0.4 0.027 14.5 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1788) DUF5513 PF17632.2 ETO22929.1 - 0.019 15.4 0.2 0.019 15.4 0.2 2.0 3 0 0 3 3 3 0 Family of unknown function (DUF5513) YtpI PF14007.6 ETO22929.1 - 0.036 14.2 0.2 0.067 13.3 0.2 1.4 1 0 0 1 1 1 0 YtpI-like protein UPF0054 PF02130.17 ETO22929.1 - 0.064 13.1 0.1 0.097 12.5 0.1 1.3 1 1 0 1 1 1 0 Uncharacterized protein family UPF0054 PYC_OADA PF02436.18 ETO22930.1 - 2.7e-21 76.2 0.1 3.7e-21 75.8 0.1 1.2 1 0 0 1 1 1 1 Conserved carboxylase domain HMGL-like PF00682.19 ETO22930.1 - 5.4e-21 75.3 0.4 1.7e-20 73.7 0.0 1.9 3 0 0 3 3 3 1 HMGL-like Mab-21 PF03281.14 ETO22930.1 - 0.076 12.3 0.0 0.21 10.9 0.0 1.7 1 1 0 1 1 1 0 Mab-21 protein Pkinase PF00069.25 ETO22931.1 - 2.6e-28 99.1 0.5 1.2e-27 96.9 0.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO22931.1 - 0.00012 21.5 0.2 0.064 12.5 0.0 2.6 2 1 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO22931.1 - 0.0022 16.8 0.1 0.0029 16.4 0.1 1.2 1 0 0 1 1 1 1 Fungal protein kinase Exosortase_EpsH PF09721.10 ETO22931.1 - 0.0076 15.8 0.6 0.012 15.2 0.6 1.2 1 0 0 1 1 1 1 Transmembrane exosortase (Exosortase_EpsH) TadE PF07811.12 ETO22931.1 - 2.2 8.6 4.7 43 4.5 4.4 2.3 2 0 0 2 2 2 0 TadE-like protein BUD22 PF09073.10 ETO22931.1 - 2.5 7.4 14.9 3.4 6.9 14.9 1.1 1 0 0 1 1 1 0 BUD22 Menin PF05053.13 ETO22931.1 - 6.1 5.1 8.1 8.6 4.6 8.1 1.1 1 0 0 1 1 1 0 Menin Corazonin PF17308.2 ETO22931.1 - 9.2 6.6 15.6 0.87 10.0 8.8 2.1 2 0 0 2 2 2 0 Pro-corazonin Nop14 PF04147.12 ETO22931.1 - 9.5 4.3 13.2 13 3.8 13.2 1.1 1 0 0 1 1 1 0 Nop14-like family Lin-8 PF03353.15 ETO22931.1 - 9.8 5.6 11.7 14 5.2 11.7 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist Pneumo_att_G PF05539.11 ETO22932.1 - 2.6 7.6 11.6 3 7.3 11.6 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Fibrillarin PF01269.17 ETO22933.1 - 2.5e-87 291.7 0.0 9.3e-72 240.8 0.0 2.0 2 0 0 2 2 2 2 Fibrillarin GCD14 PF08704.10 ETO22933.1 - 0.027 14.1 0.0 0.047 13.4 0.0 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Ras PF00071.22 ETO22934.1 - 6.9e-31 107.0 0.8 1.8e-30 105.7 0.8 1.7 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO22934.1 - 8.9e-08 32.4 0.1 4.2e-06 27.0 0.1 2.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO22934.1 - 0.004 16.6 0.2 0.018 14.5 0.2 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family GDI PF00996.18 ETO22935.1 - 6.6e-72 242.4 0.0 3.7e-42 144.4 0.0 2.0 1 1 1 2 2 2 2 GDP dissociation inhibitor NAD_binding_10 PF13460.6 ETO22937.1 - 4.5e-10 39.7 0.0 1.4e-09 38.1 0.0 1.7 1 1 1 2 2 2 1 NAD(P)H-binding Epimerase PF01370.21 ETO22937.1 - 9.3e-09 35.1 0.0 1.4e-08 34.5 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF4215 PF13948.6 ETO22937.1 - 0.051 14.0 0.3 0.12 12.8 0.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4215) 3Beta_HSD PF01073.19 ETO22937.1 - 0.074 12.0 0.0 0.13 11.2 0.0 1.5 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family LEA_4 PF02987.16 ETO22937.1 - 0.26 11.4 10.5 0.67 10.1 10.5 1.7 1 1 0 1 1 1 0 Late embryogenesis abundant protein YtxH PF12732.7 ETO22937.1 - 1.9 9.1 7.4 3.1 8.4 7.4 1.4 1 0 0 1 1 1 0 YtxH-like protein EMP24_GP25L PF01105.24 ETO22938.1 - 1.8e-18 67.1 0.1 2.1e-18 66.9 0.1 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD WD40 PF00400.32 ETO22941.1 - 2.5e-54 180.0 13.3 1.8e-10 41.2 0.1 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22941.1 - 1.3e-15 57.4 5.1 9.9e-05 22.6 0.1 5.3 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22941.1 - 4.5e-15 55.4 2.9 0.00031 19.8 0.0 5.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO22941.1 - 8e-06 24.6 1.8 0.61 8.6 0.0 3.1 2 1 1 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO22941.1 - 0.00021 20.1 9.8 1.8 7.1 1.7 5.1 1 1 3 5 5 5 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO22941.1 - 0.00027 20.4 0.9 0.34 10.2 0.1 3.1 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal WD40_like PF17005.5 ETO22941.1 - 0.0023 17.3 4.6 0.026 13.8 1.0 3.3 2 2 3 5 5 5 1 WD40-like domain Caudo_bapla_RBP PF08931.10 ETO22941.1 - 0.023 14.2 0.5 11 5.4 0.0 3.3 3 1 0 3 3 3 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head Coatomer_WDAD PF04053.14 ETO22941.1 - 0.024 13.7 5.0 0.97 8.4 0.1 3.0 2 2 1 3 3 3 0 Coatomer WD associated region Big_7 PF17957.1 ETO22941.1 - 0.099 13.4 0.8 15 6.4 0.0 3.2 3 1 0 3 3 3 0 Bacterial Ig domain PD40 PF07676.12 ETO22941.1 - 0.13 12.2 2.1 8 6.5 0.1 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Ribosomal_L34e PF01199.18 ETO22942.1 - 0.17 12.2 0.3 0.67 10.3 0.1 1.9 2 0 0 2 2 2 0 Ribosomal protein L34e WW PF00397.26 ETO22943.1 - 3.6e-06 27.0 0.7 3.6e-06 27.0 0.7 2.3 2 0 0 2 2 2 1 WW domain Macoilin PF09726.9 ETO22943.1 - 0.0051 15.4 5.5 0.0069 15.0 5.5 1.2 1 0 0 1 1 1 1 Macoilin family Glyco_hyd_101C PF17451.2 ETO22943.1 - 1.1 9.6 5.8 0.17 12.2 0.5 2.2 2 1 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain Isy1 PF06246.12 ETO22944.1 - 0.0032 17.1 0.5 0.0041 16.7 0.5 1.1 1 0 0 1 1 1 1 Isy1-like splicing family DUF4251 PF14059.6 ETO22944.1 - 7.5 6.5 11.2 8.1 6.4 2.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4251) Nckap1 PF09735.9 ETO22945.1 - 8e-15 53.9 5.5 1.5e-14 53.1 5.5 1.4 1 1 0 1 1 1 1 Membrane-associated apoptosis protein DUF3199 PF11436.8 ETO22945.1 - 0.084 12.9 0.2 7.3 6.6 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3199) CH PF00307.31 ETO22946.1 - 3.6e-08 33.6 0.0 5.9e-08 32.9 0.0 1.3 1 0 0 1 1 1 1 Calponin homology (CH) domain DUF778 PF05608.12 ETO22947.1 - 2.2 8.6 5.9 0.42 10.9 1.8 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF778) UCH PF00443.29 ETO22948.1 - 1.4e-34 119.8 3.5 2.2e-34 119.1 3.5 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO22948.1 - 2.1e-20 73.6 3.9 8.3e-20 71.6 3.9 1.9 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Mpv17_PMP22 PF04117.12 ETO22948.1 - 0.1 12.8 0.1 0.34 11.2 0.1 1.9 1 0 0 1 1 1 0 Mpv17 / PMP22 family NPR3 PF03666.13 ETO22949.1 - 2.4 6.9 9.1 3 6.5 9.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 ETO22949.1 - 8.6 5.1 6.6 10 4.8 6.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Phage_P2_GpE PF06528.12 ETO22950.1 - 0.083 12.5 0.0 2.3 7.8 0.0 2.4 2 0 0 2 2 2 0 Phage P2 GpE NDUF_B6 PF09782.9 ETO22951.1 - 0.75 9.9 3.4 3 8.0 0.0 2.8 3 1 0 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFB6/B17 subunit Ank_4 PF13637.6 ETO22953.1 - 1.7e-15 57.1 1.5 1.2e-05 25.8 0.1 3.3 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO22953.1 - 1.4e-13 51.2 1.2 1.5e-08 35.1 0.0 3.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO22953.1 - 1.1e-12 47.8 2.8 0.00079 19.8 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ETO22953.1 - 2.4e-12 46.8 0.7 5.7e-05 23.3 0.0 4.3 4 1 1 5 5 5 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO22953.1 - 1.5e-10 40.3 5.1 0.0022 18.3 0.1 4.4 3 1 0 3 3 3 3 Ankyrin repeat AhpC-TSA_2 PF13911.6 ETO22953.1 - 0.0078 16.3 0.1 0.017 15.2 0.1 1.4 1 1 0 1 1 1 1 AhpC/TSA antioxidant enzyme CEL_III_C PF18054.1 ETO22953.1 - 0.019 15.0 2.2 0.044 13.8 2.2 1.6 1 0 0 1 1 1 0 CEL-III C-terminal Nop14 PF04147.12 ETO22955.1 - 0.024 12.9 39.1 0.035 12.3 39.1 1.2 1 0 0 1 1 1 0 Nop14-like family DUF872 PF05915.12 ETO22955.1 - 0.12 12.6 2.3 0.25 11.5 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) DUF996 PF06195.13 ETO22955.1 - 2.3 8.5 11.4 2.7 8.3 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF996) Mpp10 PF04006.12 ETO22955.1 - 4.3 5.6 35.3 8 4.8 35.3 1.4 1 0 0 1 1 1 0 Mpp10 protein PBP1_TM PF14812.6 ETO22955.1 - 4.5 7.7 0.0 4.5 7.7 0.0 5.0 2 1 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SK_channel PF03530.14 ETO22955.1 - 8.3 6.4 10.6 12 5.9 0.6 2.4 2 0 0 2 2 2 0 Calcium-activated SK potassium channel DUF4808 PF16066.5 ETO22955.1 - 9.6 6.8 9.5 23 5.5 0.0 3.5 2 2 2 4 4 4 0 Domain of unknown function (DUF4808) Kelch_1 PF01344.25 ETO22956.1 - 2.4e-06 27.0 0.2 1.4e-05 24.6 0.1 2.3 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO22956.1 - 1.4e-05 25.2 0.0 3.9e-05 23.8 0.0 1.7 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO22956.1 - 4.3e-05 23.3 0.6 0.0027 17.6 0.1 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO22956.1 - 0.00017 21.5 0.0 0.00088 19.2 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO22956.1 - 0.0049 17.1 1.2 0.025 14.9 0.1 2.7 3 0 0 3 3 3 1 Kelch motif CYTH PF01928.21 ETO22956.1 - 0.055 13.4 0.1 0.091 12.7 0.1 1.3 1 0 0 1 1 1 0 CYTH domain Kelch_5 PF13854.6 ETO22956.1 - 0.087 12.8 1.5 0.5 10.4 0.3 2.7 3 0 0 3 3 3 0 Kelch motif TFB6 PF17110.5 ETO22956.1 - 0.13 12.0 0.9 0.21 11.3 0.9 1.3 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH TPX2 PF06886.11 ETO22956.1 - 1.6 9.0 6.9 0.32 11.3 3.4 1.6 2 0 0 2 2 2 0 Targeting protein for Xklp2 (TPX2) WD40 PF00400.32 ETO22957.1 - 2.5e-52 173.7 23.4 3e-09 37.4 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22957.1 - 2.7e-21 75.6 6.7 0.008 16.4 0.5 6.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22957.1 - 3e-18 65.9 1.6 0.06 12.3 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO22957.1 - 1.5e-10 40.9 0.5 0.0022 17.4 0.0 3.9 2 2 2 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETO22957.1 - 2.7e-08 33.9 0.7 0.028 14.3 0.1 3.5 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO22957.1 - 2.8e-07 29.4 1.3 0.0073 14.9 0.0 3.2 1 1 3 4 4 4 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO22957.1 - 3.4e-07 29.3 11.4 0.037 12.7 0.1 5.3 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Ricin_B_lectin PF00652.22 ETO22957.1 - 8.2e-06 26.1 7.0 0.011 15.9 1.3 2.9 1 1 1 3 3 3 3 Ricin-type beta-trefoil lectin domain Nucleoporin_N PF08801.11 ETO22957.1 - 0.00014 20.8 4.3 0.25 10.1 0.1 4.1 1 1 4 5 5 5 2 Nup133 N terminal like Frtz PF11768.8 ETO22957.1 - 0.00018 20.0 3.3 0.22 9.8 0.1 3.0 1 1 2 3 3 3 3 WD repeat-containing and planar cell polarity effector protein Fritz Utp8 PF10395.9 ETO22957.1 - 0.0002 20.0 0.2 0.053 12.0 0.1 2.7 1 1 1 3 3 3 2 Utp8 family DUF5570 PF17731.1 ETO22957.1 - 0.0014 18.7 3.5 4.4 7.4 0.1 4.3 2 2 3 5 5 5 1 Family of unknown function (DUF5570) NHL PF01436.21 ETO22957.1 - 0.0014 18.6 1.4 0.35 11.0 0.0 4.0 4 0 0 4 4 4 1 NHL repeat DUF4999 PF16390.5 ETO22957.1 - 0.0015 18.7 1.5 17 5.7 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function HPS3_N PF14761.6 ETO22957.1 - 0.0017 17.9 0.4 0.24 10.9 0.1 2.6 2 1 0 2 2 2 1 Hermansky-Pudlak syndrome 3 VID27 PF08553.10 ETO22957.1 - 0.004 16.3 0.0 0.052 12.6 0.0 2.2 2 0 0 2 2 2 1 VID27 C-terminal WD40-like domain DUF4988 PF16378.5 ETO22957.1 - 0.019 14.6 0.2 0.37 10.4 0.0 2.8 3 1 0 3 3 3 0 Domain of unknown function PD40 PF07676.12 ETO22957.1 - 0.044 13.7 7.2 10 6.2 0.0 5.5 7 1 1 8 8 7 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO22958.1 - 1e-51 171.8 25.5 1.1e-08 35.6 0.5 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22958.1 - 6.8e-11 42.3 0.8 0.00076 19.7 0.0 4.1 3 2 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO22958.1 - 6.5e-07 28.6 0.1 0.013 14.5 0.2 3.6 3 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO22958.1 - 0.00096 17.9 7.3 3.5 6.2 0.0 5.4 3 2 3 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO22958.1 - 0.91 8.2 3.3 2.4 6.8 0.2 2.9 3 2 1 4 4 4 0 Nup133 N terminal like WD40 PF00400.32 ETO22959.1 - 1.4e-41 139.7 34.0 6.9e-08 33.0 0.2 8.1 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22959.1 - 8.1e-14 51.7 2.2 0.048 14.0 0.1 6.5 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO22959.1 - 1.2e-05 25.2 0.6 0.00093 19.1 0.1 3.6 1 1 3 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO22959.1 - 5.7e-05 22.0 14.3 0.015 14.0 1.0 5.2 3 2 1 4 4 4 3 Nucleoporin Nup120/160 CCDC92 PF14916.6 ETO22959.1 - 0.83 9.5 9.7 0.16 11.7 1.2 2.7 2 0 0 2 2 2 0 Coiled-coil domain of unknown function DUF4527 PF15030.6 ETO22959.1 - 1.6 8.1 9.6 2.4 7.5 9.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4527) Gcd10p PF04189.13 ETO22961.1 - 2.5e-42 145.0 1.1 3.1e-42 144.7 1.1 1.1 1 0 0 1 1 1 1 Gcd10p family DUF3079 PF11278.8 ETO22961.1 - 1.6 8.6 0.0 1.6 8.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3079) Creatinase_N_2 PF16189.5 ETO22962.1 - 7.3e-49 166.0 2.0 2.6e-48 164.1 1.0 2.3 3 0 0 3 3 3 1 Creatinase/Prolidase N-terminal domain Peptidase_M24 PF00557.24 ETO22962.1 - 8.1e-37 126.9 0.0 1.2e-36 126.4 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Peptidase_M24_C PF16188.5 ETO22962.1 - 1.3e-22 79.7 0.6 3e-22 78.4 0.1 2.0 2 0 0 2 2 2 1 C-terminal region of peptidase_M24 Creatinase_N PF01321.18 ETO22962.1 - 3.1e-21 76.4 0.0 6.2e-16 59.2 0.0 2.4 2 0 0 2 2 2 2 Creatinase/Prolidase N-terminal domain TnpW PF14202.6 ETO22962.1 - 0.11 12.4 0.1 0.22 11.4 0.1 1.6 1 0 0 1 1 1 0 Transposon-encoded protein TnpW HEPN_RES_NTD1 PF18870.1 ETO22963.1 - 0.041 14.1 0.1 0.17 12.1 0.1 2.1 1 1 0 1 1 1 0 HEPN/RES N-terminal domain 1 AAA_14 PF13173.6 ETO22965.1 - 0.0012 18.9 1.2 0.0057 16.7 0.0 2.7 3 0 0 3 3 3 1 AAA domain AAA PF00004.29 ETO22965.1 - 0.0042 17.5 0.2 0.025 15.0 0.0 2.3 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO22965.1 - 0.0091 16.0 0.0 0.17 11.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) THDPS_N_2 PF14805.6 ETO22966.1 - 0.082 13.2 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 Tetrahydrodipicolinate N-succinyltransferase N-terminal Roc PF08477.13 ETO22967.1 - 0.03 14.6 0.6 0.26 11.5 0.4 2.5 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase NLE PF08154.12 ETO22967.1 - 0.03 14.8 1.0 2.7 8.6 0.1 3.0 2 0 0 2 2 2 0 NLE (NUC135) domain fn3 PF00041.21 ETO22969.1 - 0.016 15.5 1.0 4.5 7.7 0.1 4.2 2 2 0 2 2 2 0 Fibronectin type III domain EF-hand_1 PF00036.32 ETO22970.1 - 7.3e-09 34.6 7.1 2.3e-06 26.7 0.4 2.7 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 ETO22970.1 - 2e-07 31.4 1.0 0.00019 21.8 0.3 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO22970.1 - 4.8e-07 29.2 2.5 0.00086 19.0 0.3 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO22970.1 - 1.7e-05 24.1 1.5 0.00029 20.2 0.5 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO22970.1 - 1.9e-05 24.4 0.3 1.9e-05 24.4 0.3 2.4 2 1 1 3 3 3 1 EF-hand domain pair YjeF_N PF03853.15 ETO22970.1 - 0.23 11.4 0.0 0.28 11.1 0.0 1.1 1 0 0 1 1 1 0 YjeF-related protein N-terminus T6PP_N PF18572.1 ETO22971.1 - 0.53 10.1 5.2 5.1 7.0 0.2 2.8 2 1 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Dfp1_Him1_M PF08630.10 ETO22971.1 - 2.6 8.3 7.6 0.2 11.9 1.3 2.0 2 0 0 2 2 2 0 Dfp1/Him1, central region HIP1_clath_bdg PF16515.5 ETO22971.1 - 2.6 8.7 14.2 5.9 7.6 6.6 2.4 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 NUDIX PF00293.28 ETO22972.1 - 2.1e-05 24.6 0.0 3.9e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain WD40 PF00400.32 ETO22974.1 - 0.025 15.4 1.6 1.9 9.5 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO22974.1 - 0.079 13.3 0.3 4.5 7.6 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Menin PF05053.13 ETO22974.1 - 0.3 9.4 6.8 0.42 8.9 6.8 1.2 1 0 0 1 1 1 0 Menin SAP18 PF06487.12 ETO22974.1 - 0.31 11.2 4.3 0.3 11.3 0.3 2.4 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) Neur_chan_memb PF02932.16 ETO22974.1 - 0.93 9.5 3.5 1.7 8.6 3.5 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1676 PF07898.13 ETO22974.1 - 4 7.4 7.2 1.4 8.9 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) FAM176 PF14851.6 ETO22974.1 - 7.7 6.2 14.0 0.97 9.1 1.2 2.4 2 0 0 2 2 2 0 FAM176 family Sec3_C PF09763.9 ETO22975.1 - 4.4e-12 45.2 0.1 5.6e-12 44.9 0.1 1.0 1 0 0 1 1 1 1 Exocyst complex component Sec3 Peptidase_C97 PF05903.14 ETO22976.1 - 0.021 14.7 0.1 0.051 13.4 0.1 1.6 1 0 0 1 1 1 0 PPPDE putative peptidase domain LRAT PF04970.13 ETO22976.1 - 0.031 14.6 0.1 0.16 12.2 0.0 2.3 2 1 0 2 2 2 0 Lecithin retinol acyltransferase fn3 PF00041.21 ETO22977.1 - 1.4e-16 60.6 2.3 0.00051 20.3 0.0 5.7 5 0 0 5 5 5 4 Fibronectin type III domain Cwf_Cwc_15 PF04889.12 ETO22977.1 - 0.0014 18.5 27.4 0.0014 18.5 27.4 3.6 3 0 0 3 3 3 1 Cwf15/Cwc15 cell cycle control protein DUF2369 PF10179.9 ETO22977.1 - 8.1 6.9 12.5 0.1 13.0 0.7 3.7 3 1 0 3 3 3 0 Uncharacterised conserved protein (DUF2369) PDZ PF00595.24 ETO22978.1 - 1.1e-06 28.9 0.3 1.7e-06 28.3 0.3 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO22978.1 - 0.00032 21.0 0.5 0.00054 20.2 0.5 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO22978.1 - 0.00043 20.1 0.2 0.00072 19.4 0.2 1.3 1 0 0 1 1 1 1 PDZ domain CRA PF06589.11 ETO22979.1 - 0.0046 17.1 5.0 0.0046 17.1 5.0 3.3 2 1 1 3 3 3 1 Circumsporozoite-related antigen (CRA) Conotoxin PF02950.17 ETO22979.1 - 0.013 16.5 0.7 0.013 16.5 0.7 3.6 2 2 2 4 4 4 0 Conotoxin DUF4778 PF16008.5 ETO22979.1 - 0.99 9.4 13.6 0.018 15.1 3.9 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4778) O-antigen_lig PF13425.6 ETO22979.1 - 4.1 6.1 9.4 0.26 10.0 0.5 2.0 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Epimerase PF01370.21 ETO22981.1 - 9e-15 54.8 0.0 6.8e-13 48.6 0.0 2.9 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO22981.1 - 2.7e-14 52.9 0.0 4.4e-13 48.9 0.0 2.4 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETO22981.1 - 2.7e-12 47.0 0.0 4.5e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NmrA PF05368.13 ETO22981.1 - 1.1e-09 38.2 0.0 5e-08 32.8 0.0 2.5 3 0 0 3 3 3 1 NmrA-like family GDP_Man_Dehyd PF16363.5 ETO22981.1 - 4.1e-09 36.3 0.0 1.9e-07 30.8 0.0 2.1 2 0 0 2 2 2 1 GDP-mannose 4,6 dehydratase KR PF08659.10 ETO22981.1 - 6.7e-05 22.9 0.0 0.00033 20.6 0.0 1.9 1 1 0 1 1 1 1 KR domain adh_short PF00106.25 ETO22981.1 - 6.8e-05 22.4 0.0 0.00012 21.6 0.0 1.3 1 0 0 1 1 1 1 short chain dehydrogenase Sacchrp_dh_NADP PF03435.18 ETO22981.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain adh_short_C2 PF13561.6 ETO22981.1 - 0.022 14.3 0.0 0.043 13.4 0.0 1.5 1 1 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase KAP PF05804.12 ETO22982.1 - 2e-73 247.7 36.9 4e-73 246.8 36.9 1.4 1 1 0 1 1 1 1 Kinesin-associated protein (KAP) CNOT11 PF10155.9 ETO22982.1 - 6.9 6.9 16.5 1.3 9.2 2.8 4.1 3 1 0 3 3 3 0 CCR4-NOT transcription complex subunit 11 KAP PF05804.12 ETO22983.1 - 2.9e-09 35.7 0.1 3.3e-09 35.5 0.1 1.1 1 0 0 1 1 1 1 Kinesin-associated protein (KAP) Mod_r PF07200.13 ETO22984.1 - 0.0017 18.5 4.6 0.0017 18.5 4.6 2.4 2 0 0 2 2 2 1 Modifier of rudimentary (Mod(r)) protein DUF3486 PF11985.8 ETO22984.1 - 0.019 15.4 1.1 0.019 15.4 1.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3486) IF-2B PF01008.17 ETO22984.1 - 0.029 13.6 1.9 0.051 12.8 1.9 1.4 1 0 0 1 1 1 0 Initiation factor 2 subunit family MADF_DNA_bdg PF10545.9 ETO22984.1 - 0.45 10.9 4.8 0.83 10.0 0.3 3.3 2 1 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like CCDC-167 PF15188.6 ETO22984.1 - 6.1 7.3 7.9 3.6 8.0 4.2 2.6 2 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 ETRAMP PF09716.10 ETO22985.1 - 0.86 9.7 4.9 1.7 8.8 4.9 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TPR_12 PF13424.6 ETO22987.1 - 1.1e-10 41.7 0.0 1.9e-10 40.9 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO22987.1 - 1e-08 34.8 0.0 1e-06 28.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO22987.1 - 9.1e-08 31.6 0.4 9.1e-08 31.6 0.4 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO22987.1 - 1.2e-06 28.1 0.2 7.3e-06 25.7 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO22987.1 - 2.5e-06 27.1 3.4 8.2e-06 25.6 0.2 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO22987.1 - 1.5e-05 24.8 6.4 0.00013 21.8 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO22987.1 - 0.0095 15.6 7.8 0.093 12.4 0.1 2.9 3 0 0 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO22987.1 - 0.043 14.2 0.1 0.24 11.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETO22987.1 - 0.064 13.3 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 ETO22987.1 - 0.098 13.3 0.0 0.15 12.7 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat Mob_Pre PF01076.19 ETO22987.1 - 0.11 12.3 0.8 0.3 10.9 0.8 1.7 1 1 0 1 1 1 0 Plasmid recombination enzyme Vwaint PF14624.6 ETO22988.1 - 0.023 14.8 0.3 0.023 14.8 0.3 1.9 2 0 0 2 2 2 0 VWA / Hh protein intein-like C_Hendra PF16821.5 ETO22988.1 - 1.8 8.4 7.3 0.9 9.4 0.7 2.5 3 0 0 3 3 3 0 C protein from hendra and measles viruses DUF3450 PF11932.8 ETO22989.1 - 2.5e-05 23.7 11.7 2.5e-05 23.7 11.7 3.4 2 1 1 3 3 3 1 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 ETO22989.1 - 0.00033 20.7 11.4 0.00033 20.7 11.4 4.1 3 1 1 4 4 4 1 TPR/MLP1/MLP2-like protein Fez1 PF06818.15 ETO22989.1 - 0.00068 20.2 34.5 0.00068 20.2 34.5 2.5 2 1 1 3 3 3 1 Fez1 Baculo_PEP_C PF04513.12 ETO22989.1 - 0.0015 18.6 1.4 0.081 13.0 0.3 2.5 2 0 0 2 2 2 1 Baculovirus polyhedron envelope protein, PEP, C terminus Hemagglutinin PF00509.18 ETO22989.1 - 0.024 13.0 0.1 0.024 13.0 0.1 2.0 2 0 0 2 2 2 0 Haemagglutinin DUF4407 PF14362.6 ETO22989.1 - 2.3 7.5 26.2 4.2 6.6 20.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 ETO22989.1 - 3.2 8.1 12.1 17 5.8 0.8 3.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) ApoO PF09769.9 ETO22989.1 - 4 7.4 6.9 4 7.4 0.6 3.3 2 1 1 3 3 3 0 Apolipoprotein O DUF2937 PF11157.8 ETO22989.1 - 4.6 6.9 5.1 1.8 8.3 0.7 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2937) AIP3 PF03915.13 ETO22990.1 - 0.0098 15.0 10.3 0.011 14.8 10.3 1.0 1 0 0 1 1 1 1 Actin interacting protein 3 APC1_C PF18122.1 ETO22990.1 - 0.022 14.7 0.4 0.032 14.2 0.4 1.5 1 1 0 1 1 1 0 Anaphase-promoting complex sub unit 1 C-terminal domain CheY-binding PF09078.11 ETO22990.1 - 0.039 14.1 0.2 0.2 11.8 0.0 2.1 2 0 0 2 2 2 0 CheY binding Fungal_trans_2 PF11951.8 ETO22990.1 - 0.041 12.7 1.2 0.048 12.5 1.2 1.1 1 0 0 1 1 1 0 Fungal specific transcription factor domain TetR_C_23 PF17931.1 ETO22990.1 - 0.054 13.6 1.0 0.054 13.6 1.0 1.8 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Fungal_TACC PF12709.7 ETO22990.1 - 0.15 12.5 12.1 0.36 11.3 3.0 2.7 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF3375 PF11855.8 ETO22990.1 - 0.54 9.1 12.1 0.065 12.1 1.1 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3375) YojJ PF10372.9 ETO22990.1 - 0.61 10.2 6.0 0.5 10.5 0.5 2.2 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus CHD5 PF04420.14 ETO22990.1 - 0.62 9.9 8.9 0.94 9.3 0.8 2.7 1 1 0 2 2 2 0 CHD5-like protein DUF4446 PF14584.6 ETO22990.1 - 2.4 8.1 9.3 0.48 10.4 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) YgaB PF14182.6 ETO22990.1 - 2.4 8.6 10.4 0.19 12.1 2.1 2.5 1 1 1 2 2 2 0 YgaB-like protein DUF1664 PF07889.12 ETO22990.1 - 2.9 7.9 6.9 18 5.4 6.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) MFMR_assoc PF16596.5 ETO22991.1 - 0.2 12.1 9.4 0.19 12.2 8.7 1.4 1 1 0 1 1 1 0 Disordered region downstream of MFMR CD36 PF01130.21 ETO22992.1 - 2.2e-26 92.5 12.4 2.5e-26 92.2 12.4 1.0 1 0 0 1 1 1 1 CD36 family SLC12 PF03522.15 ETO22993.1 - 1.9e-15 56.9 25.5 7.5e-08 31.8 0.0 4.2 3 1 0 3 3 3 3 Solute carrier family 12 Myc_N PF01056.18 ETO22993.1 - 0.031 14.2 13.0 0.05 13.5 13.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Pes-10 PF07149.11 ETO22993.1 - 0.066 12.3 21.8 0.039 13.0 18.4 2.0 2 0 0 2 2 2 0 Pes-10 DcuC PF03606.15 ETO22993.1 - 0.071 11.5 0.5 2.4 6.5 2.5 2.0 2 0 0 2 2 2 0 C4-dicarboxylate anaerobic carrier ATP-synt_G PF04718.15 ETO22993.1 - 0.1 13.5 0.1 0.41 11.5 0.0 2.0 2 0 0 2 2 1 0 Mitochondrial ATP synthase g subunit Zip PF02535.22 ETO22993.1 - 0.21 10.7 11.9 0.32 10.2 11.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter PBP1_TM PF14812.6 ETO22993.1 - 0.23 11.9 13.1 1.1 9.7 12.4 2.6 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4604 PF15377.6 ETO22993.1 - 0.24 11.8 22.4 0.44 11.0 22.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) CDC45 PF02724.14 ETO22993.1 - 0.26 9.5 19.0 0.38 9.0 19.0 1.2 1 0 0 1 1 1 0 CDC45-like protein SMYLE_N PF18615.1 ETO22993.1 - 0.34 10.4 9.3 0.53 9.8 9.3 1.2 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TRAP_alpha PF03896.16 ETO22993.1 - 0.44 9.7 11.6 0.89 8.7 11.6 1.5 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit UPF0560 PF10577.9 ETO22993.1 - 0.7 8.3 11.4 1.2 7.6 11.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 RR_TM4-6 PF06459.12 ETO22993.1 - 1.2 8.9 27.0 1.8 8.3 27.0 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO22993.1 - 1.3 7.7 15.0 2 7.1 15.0 1.2 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 ETO22993.1 - 1.8 6.9 8.9 2.9 6.2 8.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Kei1 PF08552.11 ETO22993.1 - 2 8.3 3.8 3.7 7.4 3.8 1.5 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 BSMAP PF12280.8 ETO22993.1 - 2 8.6 6.2 4.5 7.4 6.2 1.5 1 0 0 1 1 1 0 Brain specific membrane anchored protein Endostatin PF06482.11 ETO22993.1 - 2.1 7.8 8.3 3.3 7.1 8.3 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin FAM60A PF15396.6 ETO22993.1 - 2.7 7.9 14.4 5.1 7.0 14.4 1.5 1 0 0 1 1 1 0 Protein Family FAM60A V_ATPase_I PF01496.19 ETO22993.1 - 3.9 5.3 19.5 2.2 6.1 13.8 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family DUF4746 PF15928.5 ETO22993.1 - 4.7 6.5 26.7 11 5.4 26.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF1676 PF07898.13 ETO22993.1 - 5.1 7.1 16.8 7.9 6.5 12.1 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1676) NOA36 PF06524.12 ETO22993.1 - 5.5 6.2 17.9 9.1 5.5 17.9 1.3 1 0 0 1 1 1 0 NOA36 protein DUF4366 PF14283.6 ETO22993.1 - 8.1 6.5 18.2 28 4.7 18.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4366) RNA_pol_Rpc4 PF05132.14 ETO22993.1 - 9.7 6.6 15.0 24 5.3 15.0 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 LptF_LptG PF03739.14 ETO22994.1 - 0.73 8.6 2.1 1 8.2 2.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG RITA PF17066.5 ETO22995.1 - 0.18 11.4 9.0 0.2 11.2 7.9 1.5 1 1 0 1 1 1 0 RBPJ-interacting and tubulin associated protein SR-25 PF10500.9 ETO22995.1 - 0.18 11.4 23.5 0.24 11.0 23.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIA PF03153.13 ETO22995.1 - 3.3 7.6 45.2 4.3 7.2 45.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sin3_corepress PF08295.12 ETO22997.1 - 1.5e-29 102.0 0.9 1.7e-29 101.7 0.9 1.1 1 0 0 1 1 1 1 Sin3 family co-repressor DUF2857 PF11198.8 ETO22997.1 - 0.066 13.0 0.0 0.084 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2857) SART-1 PF03343.13 ETO22997.1 - 0.12 10.9 4.8 0.13 10.8 4.8 1.0 1 0 0 1 1 1 0 SART-1 family Sin3a_C PF16879.5 ETO22998.1 - 1.4e-06 28.2 6.0 8.5e-06 25.7 0.0 2.3 2 1 1 3 3 3 2 C-terminal domain of Sin3a protein Pkinase PF00069.25 ETO22999.1 - 6.7e-05 22.4 0.0 0.00011 21.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF3899 PF13038.6 ETO22999.1 - 0.16 12.5 0.1 0.16 12.5 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF3899) G-patch_2 PF12656.7 ETO23000.1 - 0.076 13.1 1.7 0.1 12.7 0.1 2.1 2 0 0 2 2 2 0 G-patch domain RasGEF PF00617.19 ETO23001.1 - 9e-32 110.7 3.2 2e-30 106.3 2.3 2.5 1 1 0 1 1 1 1 RasGEF domain Mvb12 PF09452.10 ETO23001.1 - 0.064 13.7 0.5 0.46 10.9 0.1 2.6 2 0 0 2 2 2 0 ESCRT-I subunit Mvb12 RasGEF_N PF00618.20 ETO23002.1 - 0.065 13.5 5.8 0.073 13.3 0.3 3.0 3 0 0 3 3 3 0 RasGEF N-terminal motif WD40 PF00400.32 ETO23003.1 - 1e-63 209.7 16.8 1.1e-09 38.7 0.1 7.2 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23003.1 - 4.3e-20 71.8 2.0 0.0019 18.5 0.0 5.9 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23003.1 - 1.9e-12 46.8 0.3 0.18 10.7 0.0 5.4 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO23003.1 - 2.2e-08 33.8 1.9 0.0034 16.7 0.0 4.4 2 1 1 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO23003.1 - 3.6e-07 29.2 3.3 2.6 6.6 0.0 4.9 1 1 2 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO23003.1 - 7.4e-05 22.6 0.3 7 6.7 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO23003.1 - 0.00011 22.3 1.9 11 6.1 0.0 4.7 2 1 3 5 5 5 1 Family of unknown function (DUF5570) SBD PF17882.1 ETO23003.1 - 0.00055 19.8 0.2 0.16 11.8 0.2 3.2 1 1 1 2 2 2 2 OAA-family lectin sugar binding domain Cytochrom_D1 PF02239.16 ETO23003.1 - 0.0013 17.3 0.0 0.0092 14.5 0.0 2.1 2 1 0 2 2 2 1 Cytochrome D1 heme domain ssDBP_DBD PF18361.1 ETO23003.1 - 0.034 14.3 0.0 1.9 8.6 0.0 3.1 4 0 0 4 4 4 0 Single stranded DNA-binding protein ss DNA binding domain Resistin PF06954.11 ETO23003.1 - 0.066 13.8 0.0 46 4.6 0.0 3.6 3 1 1 4 4 4 0 Resistin Str_synth PF03088.16 ETO23003.1 - 0.078 13.1 0.0 11 6.2 0.0 3.4 3 0 0 3 3 3 0 Strictosidine synthase Caudo_bapla_RBP PF08931.10 ETO23003.1 - 0.1 12.0 1.8 7 6.0 0.1 3.0 3 1 0 3 3 3 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head UNC-93 PF05978.16 ETO23004.1 - 2e-07 30.9 16.2 2e-07 30.9 16.2 2.5 1 1 1 2 2 2 1 Ion channel regulatory protein UNC-93 DUF373 PF04123.13 ETO23004.1 - 0.85 9.0 10.5 3.5 7.0 10.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF373) DUF3336 PF11815.8 ETO23005.1 - 0.0073 16.0 0.7 0.01 15.5 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) DUF2205 PF10224.9 ETO23005.1 - 0.0082 16.1 0.7 0.015 15.3 0.7 1.5 1 0 0 1 1 1 1 Short coiled-coil protein APG6_N PF17675.1 ETO23005.1 - 0.014 15.9 2.6 0.022 15.3 2.6 1.2 1 0 0 1 1 1 0 Apg6 coiled-coil region DUF1664 PF07889.12 ETO23005.1 - 0.023 14.7 1.1 0.059 13.4 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Fib_alpha PF08702.10 ETO23005.1 - 0.034 14.3 3.8 0.049 13.8 3.8 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family THOC7 PF05615.13 ETO23005.1 - 0.055 13.7 2.9 0.087 13.1 2.9 1.4 1 1 0 1 1 1 0 Tho complex subunit 7 DUF2730 PF10805.8 ETO23005.1 - 0.062 13.4 1.4 0.081 13.0 0.5 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) ASL_C PF08328.11 ETO23005.1 - 0.072 13.2 0.4 0.095 12.8 0.4 1.4 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal Ras PF00071.22 ETO23006.1 - 5.6e-38 130.1 0.1 7e-38 129.8 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO23006.1 - 1.2e-16 61.0 0.0 2.5e-16 60.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO23006.1 - 2e-10 40.4 0.0 2.6e-10 40.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO23006.1 - 0.0015 18.1 0.0 0.0022 17.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Macoilin PF09726.9 ETO23008.1 - 0.0016 17.1 2.8 0.0019 16.9 2.8 1.0 1 0 0 1 1 1 1 Macoilin family Nop14 PF04147.12 ETO23008.1 - 0.0099 14.1 21.1 0.012 13.9 21.1 1.0 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO23008.1 - 0.036 13.5 23.6 0.051 13.0 23.6 1.2 1 0 0 1 1 1 0 SDA1 DUF3494 PF11999.8 ETO23008.1 - 0.074 12.7 0.0 11 5.6 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3494) SLC12 PF03522.15 ETO23008.1 - 0.42 9.6 3.4 0.55 9.2 3.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SAPS PF04499.15 ETO23008.1 - 0.44 9.3 8.4 0.52 9.0 8.4 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO23008.1 - 0.53 8.5 17.1 0.71 8.1 17.1 1.2 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO23008.1 - 1.5 8.1 21.9 2 7.6 21.9 1.1 1 0 0 1 1 1 0 BUD22 RRN3 PF05327.11 ETO23008.1 - 4.9 5.6 18.3 6.6 5.1 18.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 SesA PF17107.5 ETO23009.1 - 0.068 13.4 2.8 0.075 13.2 0.6 2.1 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Sporozoite_P67 PF05642.11 ETO23009.1 - 6.3 4.8 15.1 0.022 12.9 5.7 1.6 2 0 0 2 2 2 0 Sporozoite P67 surface antigen MscS_TM PF12794.7 ETO23011.1 - 4.6 6.0 6.3 16 4.3 6.3 1.9 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 WD40 PF00400.32 ETO23013.1 - 1.1e-05 26.1 4.1 0.06 14.2 0.4 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat HEPN_STY4199 PF18729.1 ETO23013.1 - 0.031 13.5 0.2 0.062 12.5 0.2 1.5 1 0 0 1 1 1 0 STY4199-like HEPN TPR_12 PF13424.6 ETO23014.1 - 1e-16 61.0 0.4 1.1e-13 51.3 0.4 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23014.1 - 4.2e-14 51.7 12.6 1.8e-07 30.7 1.2 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23014.1 - 1.2e-12 47.0 9.5 2.2e-06 27.4 0.6 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23014.1 - 5.8e-12 44.7 3.1 2.5e-05 24.0 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO23014.1 - 4.4e-11 42.3 0.2 0.00017 21.3 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23014.1 - 1.7e-10 40.2 11.1 1.2e-05 25.0 0.6 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO23014.1 - 2.9e-05 24.6 0.8 0.034 14.8 0.1 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO23014.1 - 2.9e-05 23.6 6.1 0.17 11.6 0.3 4.0 3 1 1 4 4 4 3 TPR repeat TPR_17 PF13431.6 ETO23014.1 - 4.8e-05 23.5 2.8 1.1 9.8 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO23014.1 - 0.00073 19.6 1.7 0.0061 16.6 0.0 2.8 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO23014.1 - 0.012 16.2 2.9 1 10.2 0.1 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO23014.1 - 0.1 13.5 0.6 4.4 8.4 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO23014.1 - 3 7.9 7.9 3.9 7.6 0.5 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO23015.1 - 0.00094 19.2 0.0 0.62 10.0 0.0 2.1 2 0 0 2 2 2 2 Caspase domain Nop14 PF04147.12 ETO23016.1 - 0.12 10.6 27.4 0.17 10.1 27.4 1.3 1 0 0 1 1 1 0 Nop14-like family Corazonin PF17308.2 ETO23016.1 - 9.9 6.5 33.7 8.3 6.8 11.5 2.5 2 0 0 2 2 2 0 Pro-corazonin WD40 PF00400.32 ETO23017.1 - 0.013 16.3 0.2 0.029 15.2 0.2 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat CRAL_TRIO PF00650.20 ETO23020.1 - 3.9e-07 29.9 1.8 8.5e-07 28.8 1.8 1.6 1 0 0 1 1 1 1 CRAL/TRIO domain DUF2420 PF10336.9 ETO23020.1 - 0.48 10.5 3.7 5.8 7.0 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2420) CRAL_TRIO PF00650.20 ETO23021.1 - 2.3e-10 40.4 0.2 3.2e-10 40.0 0.2 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain CAP_GLY PF01302.25 ETO23022.1 - 2.2e-10 40.4 0.2 5.5e-10 39.1 0.2 1.7 1 0 0 1 1 1 1 CAP-Gly domain META PF03724.16 ETO23023.1 - 0.044 13.7 1.0 0.089 12.8 1.0 1.5 1 0 0 1 1 1 0 META domain CDC27 PF09507.10 ETO23023.1 - 0.046 13.1 23.7 0.053 12.9 23.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 ETO23023.1 - 0.36 9.1 21.9 0.57 8.4 21.9 1.5 1 0 0 1 1 1 0 CDC45-like protein Myc_N PF01056.18 ETO23023.1 - 0.43 10.4 20.4 0.84 9.5 20.4 1.6 1 1 0 1 1 1 0 Myc amino-terminal region TFIIA PF03153.13 ETO23023.1 - 0.55 10.2 22.4 0.76 9.7 22.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MOZ_SAS PF01853.18 ETO23024.1 - 4.5e-51 173.0 6.6 2.8e-50 170.4 6.6 2.2 1 1 0 1 1 1 1 MOZ/SAS family zf-MYST PF17772.1 ETO23024.1 - 1.7e-14 53.1 10.1 2.2e-14 52.8 8.4 2.1 2 0 0 2 2 2 1 MYST family zinc finger domain Tudor-knot PF11717.8 ETO23024.1 - 1.9e-08 34.0 0.1 5.9e-08 32.5 0.0 1.9 2 0 0 2 2 2 1 RNA binding activity-knot of a chromodomain TPPII_N PF12583.8 ETO23024.1 - 0.32 11.6 6.6 0.77 10.3 6.6 1.7 1 0 0 1 1 1 0 Tripeptidyl peptidase II N terminal Not1 PF04054.15 ETO23025.1 - 4.9e-94 315.3 5.9 7.2e-94 314.7 5.9 1.2 1 0 0 1 1 1 1 CCR4-Not complex component, Not1 DUF3819 PF12842.7 ETO23026.1 - 1.9e-29 102.5 5.2 1.9e-29 102.5 5.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF3819) Kin17_mid PF10357.9 ETO23026.1 - 2.2 8.2 6.3 0.64 9.9 2.1 2.2 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein HET PF06985.11 ETO23026.1 - 3 8.2 5.8 8.3 6.8 0.2 3.4 2 1 0 3 3 3 0 Heterokaryon incompatibility protein (HET) ASFV_J13L PF05568.11 ETO23027.1 - 0.0024 17.7 0.2 0.0024 17.7 0.2 2.3 3 0 0 3 3 3 1 African swine fever virus J13L protein WBP-1 PF11669.8 ETO23027.1 - 0.0098 16.5 0.0 0.043 14.5 0.0 2.2 1 0 0 1 1 1 1 WW domain-binding protein 1 DUF929 PF06053.11 ETO23027.1 - 0.051 12.9 2.7 0.12 11.6 2.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Neur_chan_memb PF02932.16 ETO23027.1 - 7.8 6.5 29.6 0.037 14.1 12.9 2.7 2 1 1 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region PPC PF04151.15 ETO23028.1 - 0.21 12.7 8.1 0.51 11.5 8.1 1.6 1 0 0 1 1 1 0 Bacterial pre-peptidase C-terminal domain KRTAP PF11759.8 ETO23028.1 - 2.4 8.8 10.4 4.8 7.8 10.4 1.4 1 0 0 1 1 1 0 Keratin-associated matrix RRM_1 PF00076.22 ETO23030.1 - 2.5e-21 75.3 0.0 1.1e-13 50.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO23030.1 - 0.015 15.3 0.0 0.42 10.7 0.0 2.4 2 0 0 2 2 2 0 RNA binding domain Sulfotransfer_3 PF13469.6 ETO23031.1 - 0.0062 16.9 0.1 0.027 14.8 0.0 2.1 2 1 0 2 2 2 1 Sulfotransferase family SpoU_methylase PF00588.19 ETO23032.1 - 1.4e-05 25.3 0.3 9.7 6.4 0.1 4.6 4 1 0 4 4 4 4 SpoU rRNA Methylase family TamB PF04357.13 ETO23033.1 - 0.1 11.8 0.2 0.2 10.9 0.2 1.4 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex DUF4932 PF16286.5 ETO23034.1 - 0.12 11.6 0.0 0.21 10.8 0.0 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4932) zf-C2H2_4 PF13894.6 ETO23036.1 - 8.8e-08 32.4 34.6 0.037 14.9 1.1 5.8 6 0 0 6 6 5 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO23036.1 - 1.6e-07 31.4 27.8 3.3e-05 24.1 0.9 5.3 5 0 0 5 5 5 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETO23036.1 - 8.3e-07 29.1 30.3 0.026 15.0 0.1 5.7 5 0 0 5 5 5 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ETO23036.1 - 0.00014 21.7 1.0 0.00014 21.7 1.0 5.2 6 0 0 6 6 6 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETO23036.1 - 0.00047 20.4 20.8 0.068 13.5 0.3 5.4 4 0 0 4 4 4 2 Zinc-finger double-stranded RNA-binding zf-MYND PF01753.18 ETO23036.1 - 0.037 14.1 0.7 0.037 14.1 0.7 4.3 4 2 0 4 4 4 0 MYND finger zf-met PF12874.7 ETO23036.1 - 0.071 13.5 22.9 3.1 8.3 0.2 5.2 4 0 0 4 4 4 0 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ETO23036.1 - 1 9.1 0.0 1 9.1 0.0 3.4 4 0 0 4 4 4 0 zinc-finger C2H2-type HypA PF01155.19 ETO23036.1 - 1.2 9.1 9.0 1.6 8.7 0.2 3.0 2 1 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Sprouty PF05210.13 ETO23036.1 - 1.8 9.0 9.4 4.1 7.8 0.3 2.7 2 0 0 2 2 2 0 Sprouty protein (Spry) zf-AN1 PF01428.16 ETO23036.1 - 7.4 6.8 14.7 7.3 6.8 0.9 4.3 4 0 0 4 4 4 0 AN1-like Zinc finger ALG11_N PF15924.5 ETO23037.1 - 1.2e-67 228.0 2.3 1.7e-67 227.5 2.3 1.2 1 0 0 1 1 1 1 ALG11 mannosyltransferase N-terminus Glycos_transf_1 PF00534.20 ETO23037.1 - 3.7e-21 75.4 0.0 7.6e-21 74.4 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO23037.1 - 8.9e-09 35.9 0.0 3.1e-08 34.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferases group 1 Voltage_CLC PF00654.20 ETO23037.1 - 0.0057 15.9 0.0 0.012 14.9 0.0 1.5 1 0 0 1 1 1 1 Voltage gated chloride channel MMPL PF03176.15 ETO23039.1 - 4.1e-35 121.3 8.3 5.1e-34 117.7 8.3 2.0 1 1 0 1 1 1 1 MMPL family TPR_12 PF13424.6 ETO23040.1 - 8.4e-45 151.0 1.0 1.2e-15 57.6 0.1 4.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23040.1 - 7.1e-34 114.3 29.9 2.4e-08 33.4 0.2 7.2 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO23040.1 - 1.2e-32 110.9 0.0 1.4e-08 34.3 0.0 6.8 7 0 0 7 7 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23040.1 - 1.4e-31 106.1 0.6 1.7e-07 30.8 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23040.1 - 8.1e-29 97.4 31.8 1.9e-07 30.7 0.1 8.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23040.1 - 5.1e-26 88.6 17.7 2.1e-06 27.4 0.1 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO23040.1 - 2.2e-12 46.4 12.5 0.038 14.4 0.2 7.3 7 1 0 7 7 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO23040.1 - 4.2e-08 33.3 2.8 0.1 13.3 0.0 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat SNAP PF14938.6 ETO23040.1 - 1.4e-07 31.2 4.5 8.2e-07 28.7 0.3 3.0 2 1 1 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 ETO23040.1 - 2.1e-07 31.2 0.0 0.25 12.3 0.0 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO23040.1 - 2.2e-06 27.2 28.4 0.0062 16.2 0.8 8.1 6 5 5 11 11 11 3 TPR repeat MIT PF04212.18 ETO23040.1 - 5.5e-05 23.2 6.2 0.15 12.2 0.0 5.1 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 ETO23040.1 - 6.5e-05 23.5 0.0 0.11 13.2 0.0 3.3 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO23040.1 - 0.00029 20.7 7.4 0.29 10.8 0.1 3.9 1 1 3 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2225) DUF5113 PF17140.4 ETO23040.1 - 0.00062 19.6 7.0 3.5 7.4 0.2 4.9 4 1 1 5 5 5 2 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETO23040.1 - 0.00065 19.5 2.7 0.41 10.3 0.3 3.5 1 1 2 3 3 3 1 26S proteasome subunit RPN7 SHNi-TPR PF10516.9 ETO23040.1 - 0.00099 18.5 0.1 1.3 8.6 0.0 3.7 3 1 0 3 3 3 1 SHNi-TPR TPR_MalT PF17874.1 ETO23040.1 - 0.0012 18.3 0.0 5 6.4 0.0 3.5 2 1 1 4 4 4 1 MalT-like TPR region TPR_19 PF14559.6 ETO23040.1 - 0.0044 17.5 0.7 1 9.9 0.0 3.8 4 1 1 5 5 5 1 Tetratricopeptide repeat DUF3856 PF12968.7 ETO23040.1 - 0.04 14.0 0.2 0.82 9.7 0.0 3.0 3 1 1 4 4 4 0 Domain of Unknown Function (DUF3856) BetaGal_dom3 PF13363.6 ETO23040.1 - 0.11 12.1 0.0 0.31 10.7 0.0 1.7 1 0 0 1 1 1 0 Beta-galactosidase, domain 3 PPR PF01535.20 ETO23040.1 - 1.9 8.9 9.6 7.9 7.0 0.0 5.5 7 0 0 7 7 5 0 PPR repeat NSF PF02071.20 ETO23040.1 - 8.9 7.6 11.0 1.4e+02 4.0 0.0 6.7 6 1 0 7 7 6 0 Aromatic-di-Alanine (AdAR) repeat DUF4471 PF14740.6 ETO23041.1 - 0.0069 15.6 4.5 0.0079 15.4 4.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) MIEAP PF16026.5 ETO23044.1 - 6.8e-11 42.7 3.7 3.7e-10 40.4 0.3 2.5 1 1 1 2 2 2 1 Mitochondria-eating protein E2_bind PF08825.10 ETO23044.1 - 0.19 11.9 2.7 9 6.5 0.4 2.7 2 0 0 2 2 2 0 E2 binding domain ETRAMP PF09716.10 ETO23044.1 - 5 7.3 6.3 1.6 8.8 0.6 2.6 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Kelch_6 PF13964.6 ETO23045.1 - 5.3e-07 29.7 4.0 0.0058 16.9 0.5 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO23045.1 - 1.4e-06 27.8 3.8 0.0028 17.2 0.4 3.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO23045.1 - 0.00024 20.9 4.6 2.1 8.5 0.0 4.1 2 1 1 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO23045.1 - 0.00091 19.4 0.6 0.013 15.8 0.1 2.9 3 1 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO23045.1 - 0.011 15.7 0.6 0.81 9.7 0.1 3.3 3 0 0 3 3 3 0 Kelch motif DUF1168 PF06658.12 ETO23046.1 - 1.3 8.8 19.2 1.7 8.4 19.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Porph_ging PF09697.10 ETO23046.1 - 1.4 9.5 7.0 2.4 8.7 6.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) AP3D1 PF06375.11 ETO23046.1 - 1.8 8.8 15.0 2.3 8.4 15.0 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Ferlin_C PF16165.5 ETO23046.1 - 3.3 7.6 11.9 6 6.8 11.9 1.4 1 0 0 1 1 1 0 Ferlin C-terminus LYRIC PF15686.5 ETO23046.1 - 4.9 6.6 13.9 6.2 6.3 13.9 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family YqhG PF11079.8 ETO23047.1 - 0.073 12.0 0.1 0.13 11.2 0.1 1.3 1 0 0 1 1 1 0 Bacterial protein YqhG of unknown function ALMT PF11744.8 ETO23047.1 - 0.092 11.6 0.8 0.34 9.7 0.1 1.9 2 0 0 2 2 2 0 Aluminium activated malate transporter C2 PF00168.30 ETO23048.1 - 9.6e-19 67.6 0.1 2e-18 66.6 0.1 1.6 1 0 0 1 1 1 1 C2 domain SPX PF03105.19 ETO23048.1 - 0.0061 16.5 16.3 0.016 15.2 2.2 3.2 3 0 0 3 3 3 2 SPX domain BRCA-2_OB3 PF09104.10 ETO23048.1 - 0.045 13.4 0.4 0.045 13.4 0.4 2.2 2 0 0 2 2 2 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 Gpr1_Fun34_YaaH PF01184.19 ETO23048.1 - 0.058 13.0 0.0 0.11 12.1 0.0 1.3 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family Shisa PF13908.6 ETO23048.1 - 0.22 11.7 1.6 1.8 8.8 0.8 2.6 2 0 0 2 2 2 0 Wnt and FGF inhibitory regulator zf-RING_2 PF13639.6 ETO23050.1 - 2.8e-11 43.6 4.2 8.3e-11 42.1 4.2 1.8 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO23050.1 - 6.1e-08 32.4 2.6 1.3e-07 31.4 2.6 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO23050.1 - 2.7e-07 30.2 1.0 2.7e-07 30.2 1.0 2.2 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ETO23050.1 - 3.7e-07 30.3 5.3 5e-07 29.9 2.1 2.6 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO23050.1 - 8e-06 25.6 2.2 1.9e-05 24.4 2.2 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO23050.1 - 2.7e-05 24.0 2.6 5.9e-05 22.9 2.6 1.6 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO23050.1 - 3.5e-05 23.6 1.7 7.8e-05 22.5 1.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETO23050.1 - 5.8e-05 22.9 1.6 0.00011 22.0 1.6 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO23050.1 - 0.0008 19.4 1.3 0.0019 18.2 1.3 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ETO23050.1 - 0.018 15.1 0.8 0.018 15.1 0.8 1.8 2 0 0 2 2 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ETO23050.1 - 0.31 11.2 2.4 1 9.5 2.4 1.9 1 0 0 1 1 1 0 RING-variant domain CENP-B_dimeris PF09026.10 ETO23050.1 - 0.35 11.3 15.9 0.067 13.6 5.0 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Astro_capsid_p PF12226.8 ETO23050.1 - 0.71 9.0 15.8 0.9 8.6 2.1 2.2 2 0 0 2 2 2 0 Turkey astrovirus capsid protein RXT2_N PF08595.11 ETO23050.1 - 2.1 8.4 25.6 0.4 10.7 1.8 3.1 3 0 0 3 3 3 0 RXT2-like, N-terminal TRAP_alpha PF03896.16 ETO23050.1 - 4.4 6.4 10.3 2.2 7.4 1.1 2.4 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit FAM60A PF15396.6 ETO23050.1 - 4.5 7.2 14.5 66 3.4 12.1 2.9 2 1 0 2 2 2 0 Protein Family FAM60A NOA36 PF06524.12 ETO23050.1 - 5.8 6.1 19.8 0.28 10.5 2.4 2.3 2 0 0 2 2 2 0 NOA36 protein Neur_chan_memb PF02932.16 ETO23050.1 - 8.7 6.3 8.1 90 3.0 6.3 2.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region GOLD_2 PF13897.6 ETO23050.1 - 9 6.8 9.8 4.4 7.8 0.6 2.5 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking RRN3 PF05327.11 ETO23051.1 - 2.8 6.4 9.4 3.5 6.1 9.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Hyccin PF09790.9 ETO23052.1 - 2.4e-22 79.5 5.6 2.1e-13 50.1 0.1 2.8 2 1 0 2 2 2 2 Hyccin WBP-1 PF11669.8 ETO23052.1 - 0.014 16.0 5.3 0.66 10.6 0.0 3.4 2 1 0 2 2 2 0 WW domain-binding protein 1 EcsB PF05975.12 ETO23052.1 - 0.068 12.0 4.4 0.016 14.0 1.1 1.6 2 0 0 2 2 2 0 Bacterial ABC transporter protein EcsB TMEM51 PF15345.6 ETO23052.1 - 0.11 12.4 0.3 8.4 6.1 0.1 2.3 2 0 0 2 2 2 0 Transmembrane protein 51 COX2_TM PF02790.15 ETO23052.1 - 0.25 11.5 4.9 0.18 12.0 0.6 2.7 2 1 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain Glucos_trans_II PF14264.6 ETO23052.1 - 0.31 10.4 9.3 0.62 9.4 4.0 2.3 2 0 0 2 2 2 0 Glucosyl transferase GtrII DUF3397 PF11877.8 ETO23052.1 - 0.76 10.0 9.7 9.9 6.4 5.7 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF3397) Rab5ip PF07019.12 ETO23052.1 - 2.8 8.6 7.0 24 5.6 3.9 2.6 2 0 0 2 2 2 0 Rab5-interacting protein (Rab5ip) YajC PF02699.15 ETO23052.1 - 7.1 6.6 6.4 20 5.1 1.5 2.5 2 0 0 2 2 2 0 Preprotein translocase subunit PUB PF09409.10 ETO23053.1 - 0.045 13.7 0.0 0.25 11.3 0.0 2.3 1 1 0 1 1 1 0 PUB domain Adap_comp_sub PF00928.21 ETO23054.1 - 5.7e-59 199.7 0.1 6.3e-59 199.5 0.1 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family muHD PF10291.9 ETO23054.1 - 0.057 12.9 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Muniscin C-terminal mu homology domain Adap_comp_sub PF00928.21 ETO23055.1 - 4e-06 26.4 0.1 6.3e-06 25.8 0.1 1.3 1 0 0 1 1 1 1 Adaptor complexes medium subunit family DUF4446 PF14584.6 ETO23055.1 - 0.008 16.2 1.6 0.014 15.4 1.6 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF4446) DUF4834 PF16118.5 ETO23055.1 - 0.018 16.0 1.3 0.031 15.2 1.3 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) HemY_N PF07219.13 ETO23055.1 - 0.025 14.8 1.4 0.039 14.1 1.4 1.3 1 0 0 1 1 1 0 HemY protein N-terminus OAD_gamma PF04277.13 ETO23055.1 - 0.04 14.5 3.4 0.04 14.5 3.4 1.9 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF2207 PF09972.9 ETO23055.1 - 0.08 11.7 1.6 0.094 11.5 1.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) EphA2_TM PF14575.6 ETO23055.1 - 0.17 12.8 4.0 0.36 11.7 4.0 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain ECSCR PF15820.5 ETO23055.1 - 0.25 11.2 5.6 0.42 10.5 5.6 1.5 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Shisa PF13908.6 ETO23055.1 - 0.38 11.0 4.6 0.61 10.3 4.6 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM156 PF15106.6 ETO23055.1 - 0.8 9.1 9.9 1.4 8.3 9.9 1.4 1 0 0 1 1 1 0 TMEM156 protein family Nop53 PF07767.11 ETO23056.1 - 0.033 13.6 18.7 0.055 12.9 18.7 1.3 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF5308 PF17233.2 ETO23056.1 - 0.63 10.3 6.8 0.12 12.6 2.8 1.7 2 1 0 2 2 2 0 Family of unknown function (DUF5308) Cwf_Cwc_15 PF04889.12 ETO23056.1 - 1.5 8.5 34.7 0.14 11.8 29.1 1.9 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CDC27 PF09507.10 ETO23056.1 - 2 7.7 21.2 3.1 7.1 21.2 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ETO23056.1 - 2.3 6.3 25.4 3.4 5.8 25.4 1.2 1 0 0 1 1 1 0 Nop14-like family PX PF00787.24 ETO23059.1 - 4.2e-14 52.5 6.2 3.1e-13 49.7 0.3 3.0 2 1 1 3 3 3 2 PX domain DUF999 PF06198.11 ETO23059.1 - 0.0086 16.1 0.6 0.02 14.9 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF999) DUF2076 PF09849.9 ETO23059.1 - 0.073 13.1 0.9 0.11 12.6 0.9 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) WD40 PF00400.32 ETO23061.1 - 0.00049 20.8 0.2 0.079 13.9 0.0 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23061.1 - 0.0035 17.6 0.0 0.029 14.7 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain RasGEF PF00617.19 ETO23062.1 - 7e-38 130.6 0.8 7e-38 130.6 0.8 1.8 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ETO23062.1 - 1.3e-11 44.6 0.2 1.3e-11 44.6 0.2 3.3 3 1 1 4 4 4 1 RasGEF N-terminal motif ABC_tran PF00005.27 ETO23063.1 - 3.1e-35 121.7 0.0 4.8e-27 95.1 0.0 2.8 2 0 0 2 2 2 2 ABC transporter ABC2_membrane_3 PF12698.7 ETO23063.1 - 9.7e-31 107.1 8.4 1.7e-30 106.4 8.4 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein AAA_21 PF13304.6 ETO23063.1 - 1e-17 64.9 0.0 1.9e-06 27.9 0.0 3.5 2 1 1 3 3 3 3 AAA domain, putative AbiEii toxin, Type IV TA system CAP_N PF01213.19 ETO23063.1 - 0.15 11.5 1.7 0.24 10.9 1.7 1.2 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal Mating_N PF12731.7 ETO23063.1 - 0.16 12.1 0.7 2.2 8.4 0.0 2.8 3 0 0 3 3 3 0 Mating-type protein beta 1 Dscam_C PF12355.8 ETO23063.1 - 0.16 12.9 1.8 0.54 11.2 1.4 2.0 2 0 0 2 2 2 0 Down syndrome cell adhesion molecule C terminal DUF3660 PF12398.8 ETO23064.1 - 0.072 13.2 0.2 0.18 11.9 0.2 1.7 1 0 0 1 1 1 0 Receptor serine/threonine kinase Metallophos_C PF14008.6 ETO23065.1 - 1.1e-17 64.6 0.0 2.4e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 ETO23065.1 - 0.00027 21.5 0.6 0.0014 19.1 0.2 2.0 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase fn3 PF00041.21 ETO23066.1 - 0.00052 20.3 0.1 0.28 11.6 0.1 2.6 2 0 0 2 2 2 2 Fibronectin type III domain PA14 PF07691.12 ETO23066.1 - 0.058 13.2 5.4 0.18 11.6 0.0 2.7 2 0 0 2 2 2 0 PA14 domain COE1_DBD PF16422.5 ETO23067.1 - 0.03 13.8 0.2 0.048 13.1 0.1 1.4 1 1 0 1 1 1 0 Transcription factor COE1 DNA-binding domain WD40 PF00400.32 ETO23069.1 - 1.4e-18 66.9 18.7 2.5e-07 31.3 0.5 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23069.1 - 1.4e-07 31.7 0.1 0.012 15.8 0.0 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23069.1 - 4.2e-07 29.0 1.5 0.0006 18.6 0.4 2.7 1 1 1 2 2 2 2 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO23069.1 - 0.012 15.4 0.3 2 8.3 0.0 2.3 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain W_rich_C PF07483.11 ETO23069.1 - 0.08 13.1 1.6 0.14 12.3 0.1 2.1 2 1 1 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain BAMBI PF06211.12 ETO23070.1 - 0.085 13.1 0.0 0.25 11.6 0.0 1.8 2 0 0 2 2 2 0 BMP and activin membrane-bound inhibitor (BAMBI) N-terminal domain DUF1798 PF08807.10 ETO23071.1 - 0.014 15.5 1.5 0.014 15.5 1.5 2.3 2 1 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) WXG100 PF06013.12 ETO23071.1 - 0.027 14.7 5.0 3.9 7.8 2.3 3.2 1 1 1 2 2 2 0 Proteins of 100 residues with WXG Baculo_PEP_C PF04513.12 ETO23071.1 - 0.028 14.5 0.1 0.028 14.5 0.1 1.8 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus IL32 PF15225.6 ETO23071.1 - 0.06 13.7 0.7 0.16 12.4 0.1 1.9 2 0 0 2 2 2 0 Interleukin 32 DUF4407 PF14362.6 ETO23071.1 - 0.13 11.6 5.6 0.24 10.7 5.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Allexi_40kDa PF05549.11 ETO23071.1 - 2 7.9 8.5 0.23 11.0 0.7 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein Ferritin-like PF12902.7 ETO23071.1 - 2.2 8.1 10.3 0.17 11.7 2.3 2.3 2 1 0 2 2 2 0 Ferritin-like TMPIT PF07851.13 ETO23071.1 - 3.8 6.7 16.0 0.26 10.5 3.9 2.1 2 0 0 2 2 2 0 TMPIT-like protein LMBR1 PF04791.16 ETO23071.1 - 7.9 5.3 8.1 9.8 4.9 8.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein YlqD PF11068.8 ETO23071.1 - 8.1 6.8 22.3 1.6 9.1 0.1 3.2 2 1 1 3 3 3 0 YlqD protein DUF883 PF05957.13 ETO23071.1 - 8.5 7.1 7.3 4.3 8.0 0.7 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) ubiquitin PF00240.23 ETO23072.1 - 4e-20 71.3 0.3 1.6e-19 69.4 0.3 2.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO23072.1 - 6.5e-09 35.5 0.6 1.5e-08 34.3 0.6 1.7 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like NAR2 PF16974.5 ETO23072.1 - 0.00095 18.6 0.4 0.17 11.3 0.0 2.3 2 0 0 2 2 2 2 High-affinity nitrate transporter accessory Ubiquitin_2 PF14560.6 ETO23072.1 - 0.047 14.1 0.1 0.24 11.9 0.1 2.2 2 0 0 2 2 2 0 Ubiquitin-like domain RHD3 PF05879.12 ETO23075.1 - 4.1e-45 154.2 3.6 4.6e-45 154.0 3.6 1.0 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) Mucin PF01456.17 ETO23076.1 - 0.00028 20.9 31.2 0.016 15.2 22.6 2.2 2 0 0 2 2 2 2 Mucin-like glycoprotein FSA_C PF10479.9 ETO23076.1 - 0.26 9.4 11.9 0.07 11.3 3.9 2.1 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus AJAP1_PANP_C PF15298.6 ETO23076.1 - 1.6 8.9 23.8 4.8 7.3 2.7 2.2 2 0 0 2 2 2 0 AJAP1/PANP C-terminus Dehydrin PF00257.19 ETO23076.1 - 10 6.7 10.7 5.9 7.4 5.4 2.3 2 0 0 2 2 2 0 Dehydrin Kelch_1 PF01344.25 ETO23077.1 - 0.0013 18.3 0.0 0.0032 17.0 0.0 1.6 1 0 0 1 1 1 1 Kelch motif Macoilin PF09726.9 ETO23077.1 - 2.5 6.6 21.7 4.5 5.7 21.7 1.4 1 0 0 1 1 1 0 Macoilin family PRP3 PF08572.10 ETO23078.1 - 1.2e-33 116.8 8.6 1.2e-19 71.0 0.2 2.3 2 0 0 2 2 2 2 pre-mRNA processing factor 3 (PRP3) ISK_Channel PF02060.15 ETO23078.1 - 0.023 14.4 0.0 0.063 13.0 0.0 1.7 1 0 0 1 1 1 0 Slow voltage-gated potassium channel DUF3169 PF11368.8 ETO23078.1 - 0.17 11.4 0.1 0.17 11.4 0.1 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DAGK_cat PF00781.24 ETO23078.1 - 0.31 10.7 0.9 0.88 9.2 0.1 1.9 2 0 0 2 2 2 0 Diacylglycerol kinase catalytic domain Arm PF00514.23 ETO23079.1 - 2e-10 40.3 0.3 0.007 16.4 0.0 4.0 4 0 0 4 4 4 3 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO23079.1 - 0.0059 17.1 0.0 1.8 9.1 0.0 2.5 2 0 0 2 2 2 2 HEAT-like repeat HEAT_2 PF13646.6 ETO23079.1 - 0.016 15.6 0.0 3.4 8.1 0.0 2.3 2 0 0 2 2 2 0 HEAT repeats HEAT PF02985.22 ETO23079.1 - 0.081 13.2 0.1 23 5.6 0.0 2.9 2 0 0 2 2 2 0 HEAT repeat Sec23_trunk PF04811.15 ETO23082.1 - 1.5e-36 126.2 0.8 1.5e-19 70.6 0.0 4.3 3 1 1 4 4 4 4 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ETO23082.1 - 5.2e-18 64.8 0.0 1.2e-17 63.6 0.0 1.6 1 0 0 1 1 1 1 Sec23/Sec24 helical domain zf-Sec23_Sec24 PF04810.15 ETO23082.1 - 3.9e-13 49.2 9.5 9.8e-13 47.9 9.5 1.8 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_BS PF08033.12 ETO23082.1 - 6.4e-11 42.8 0.0 2e-10 41.3 0.0 1.9 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Inhibitor_I71 PF12628.7 ETO23082.1 - 0.1 12.5 5.4 0.039 13.8 0.9 2.2 2 0 0 2 2 2 0 Falstatin, cysteine peptidase inhibitor Secretin_N_2 PF07655.13 ETO23082.1 - 2.1 8.9 19.9 0.63 10.6 15.0 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain CAP_GLY PF01302.25 ETO23083.1 - 4.4e-07 29.8 0.3 1.2e-06 28.4 0.1 1.9 2 0 0 2 2 2 1 CAP-Gly domain BP28CT PF08146.12 ETO23083.1 - 0.052 13.4 1.0 0.13 12.1 1.0 1.6 1 0 0 1 1 1 0 BP28CT (NUC211) domain 2OG-FeII_Oxy_3 PF13640.6 ETO23084.1 - 5.5e-15 56.0 0.0 1.3e-14 54.8 0.0 1.7 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ETO23084.1 - 0.012 16.0 0.5 0.097 13.2 0.0 2.5 2 2 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily VIT_2 PF13757.6 ETO23084.1 - 0.064 13.1 0.0 0.59 10.1 0.0 2.3 2 0 0 2 2 2 0 Vault protein inter-alpha-trypsin domain CK_II_beta PF01214.18 ETO23086.1 - 6e-53 179.4 3.5 1.3e-29 103.3 0.0 2.2 1 1 0 2 2 2 2 Casein kinase II regulatory subunit Tmemb_9 PF05434.11 ETO23086.1 - 0.036 13.9 1.1 0.097 12.6 0.2 2.1 2 0 0 2 2 2 0 TMEM9 HscB_4_cys PF18256.1 ETO23086.1 - 0.34 10.8 2.2 3.4 7.6 0.4 2.5 2 0 0 2 2 2 0 Co-chaperone HscB tetracysteine metal binding motif GSG-1 PF07803.11 ETO23086.1 - 0.87 9.5 4.0 0.72 9.8 2.2 1.8 2 0 0 2 2 2 0 GSG1-like protein DEAD PF00270.29 ETO23087.1 - 2.8e-42 144.5 0.8 6.6e-42 143.3 0.8 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO23087.1 - 4.5e-32 110.7 0.1 4.7e-31 107.4 0.1 2.7 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO23087.1 - 7.4e-07 29.3 0.0 2.6e-06 27.6 0.0 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit SAM_PNT PF02198.16 ETO23087.1 - 0.00018 21.4 0.1 0.00043 20.2 0.1 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain AAA_30 PF13604.6 ETO23087.1 - 0.00058 19.6 0.1 0.00095 18.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETO23087.1 - 0.0023 18.3 0.3 0.0085 16.4 0.1 2.1 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO23087.1 - 0.0061 16.8 1.5 0.042 14.1 0.7 2.8 2 2 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 ETO23087.1 - 0.0064 16.4 0.0 0.017 14.9 0.0 1.7 1 0 0 1 1 1 1 Helicase Syja_N PF02383.18 ETO23087.1 - 0.046 13.0 0.1 0.13 11.6 0.1 1.7 1 0 0 1 1 1 0 SacI homology domain PhoH PF02562.16 ETO23087.1 - 0.087 12.3 0.1 0.19 11.1 0.1 1.6 1 0 0 1 1 1 0 PhoH-like protein SAM_1 PF00536.30 ETO23087.1 - 0.2 12.1 1.9 0.42 11.1 0.8 2.2 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) IQ PF00612.27 ETO23088.1 - 0.0018 17.9 1.0 0.004 16.8 1.0 1.7 1 0 0 1 1 1 1 IQ calmodulin-binding motif DUF3280 PF11684.8 ETO23088.1 - 2.3 8.6 10.0 1.5 9.2 2.0 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF2380) TFIIA PF03153.13 ETO23090.1 - 0.022 14.8 12.9 0.02 14.9 12.9 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Med15 PF09606.10 ETO23090.1 - 0.064 11.9 20.1 0.065 11.9 20.1 1.0 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal Med3 PF11593.8 ETO23090.1 - 0.086 12.0 15.4 0.098 11.8 15.4 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Spt20 PF12090.8 ETO23090.1 - 0.088 12.4 20.3 0.11 12.1 20.3 1.2 1 0 0 1 1 1 0 Spt20 family ABC2_membrane_3 PF12698.7 ETO23090.1 - 0.2 10.7 0.7 0.21 10.6 0.7 1.0 1 0 0 1 1 1 0 ABC-2 family transporter protein UPF0560 PF10577.9 ETO23090.1 - 0.2 10.1 10.0 0.23 9.9 10.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Hydin_ADK PF17213.3 ETO23090.1 - 0.45 10.8 5.6 0.62 10.3 5.6 1.2 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Suf PF05843.14 ETO23090.1 - 0.65 9.9 8.7 0.69 9.8 8.7 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 ETO23090.1 - 0.96 8.1 5.2 1.1 8.0 5.2 1.1 1 0 0 1 1 1 0 Presenilin DUF5421 PF17458.2 ETO23090.1 - 2 7.7 16.8 1.5 8.2 15.5 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5421) Ras PF00071.22 ETO23091.1 - 3.9e-48 163.1 1.1 5.3e-48 162.7 1.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO23091.1 - 2.7e-25 88.9 0.9 4.5e-25 88.2 0.3 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO23091.1 - 4.3e-14 52.4 0.2 5.7e-14 51.9 0.2 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO23091.1 - 2.2e-06 27.2 1.2 5.5e-06 25.9 1.2 1.6 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO23091.1 - 2.7e-06 27.5 0.3 4.8e-05 23.4 0.0 2.1 1 1 1 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ETO23091.1 - 0.0003 21.1 0.0 0.00079 19.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO23091.1 - 0.0015 18.9 0.1 0.0031 17.9 0.1 1.6 1 1 0 1 1 1 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO23091.1 - 0.0017 18.3 0.5 0.088 12.7 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase Septin PF00735.18 ETO23091.1 - 0.018 14.4 0.1 0.041 13.2 0.0 1.6 2 0 0 2 2 2 0 Septin ATPase_2 PF01637.18 ETO23091.1 - 0.026 14.4 0.4 0.11 12.4 0.0 2.0 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_24 PF13479.6 ETO23091.1 - 0.037 13.8 0.4 0.11 12.3 0.4 1.9 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO23091.1 - 0.057 13.3 0.1 0.11 12.4 0.1 1.5 1 0 0 1 1 1 0 NACHT domain DUF3326 PF11805.8 ETO23091.1 - 0.082 11.8 0.0 0.11 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3326) TniB PF05621.11 ETO23091.1 - 0.13 11.7 0.0 0.22 10.9 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein Nif11 PF07862.11 ETO23091.1 - 0.14 12.5 0.7 9.6 6.6 0.0 2.7 3 0 0 3 3 2 0 Nif11 domain cobW PF02492.19 ETO23091.1 - 0.14 11.7 1.2 0.56 9.8 0.4 2.1 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain Sulfotransfer_2 PF03567.14 ETO23093.1 - 3e-06 27.3 0.9 7.1e-06 26.1 0.9 1.6 1 0 0 1 1 1 1 Sulfotransferase family Flavodoxin_5 PF12724.7 ETO23094.1 - 0.021 15.1 0.5 0.094 13.0 0.5 2.2 1 0 0 1 1 1 0 Flavodoxin domain zf-RING_UBOX PF13445.6 ETO23095.1 - 6.4e-05 22.9 8.8 0.00016 21.6 8.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_2 PF13639.6 ETO23095.1 - 0.0001 22.5 8.5 0.0001 22.5 8.5 1.8 1 1 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ETO23095.1 - 0.0014 18.6 8.8 0.036 14.0 10.2 2.3 1 1 1 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO23095.1 - 0.002 18.0 7.1 0.0067 16.3 7.3 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO23095.1 - 0.013 15.3 5.5 0.66 9.9 7.4 2.5 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETO23095.1 - 0.05 13.2 3.7 0.096 12.3 3.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-C3HC4_4 PF15227.6 ETO23095.1 - 0.19 11.9 9.4 0.83 9.9 9.4 2.2 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETO23095.1 - 0.47 10.4 13.9 36 4.3 15.0 2.6 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 IBR PF01485.21 ETO23095.1 - 1.8 8.9 0.1 1.8 8.9 0.1 2.8 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain FAM176 PF14851.6 ETO23096.1 - 1.7e-06 27.8 0.2 0.0011 18.6 0.0 2.5 2 0 0 2 2 2 2 FAM176 family LRR19-TM PF15176.6 ETO23096.1 - 0.014 15.4 0.3 5.9 7.0 0.1 3.0 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Saf_2TM PF18303.1 ETO23096.1 - 0.61 9.7 7.7 5.4 6.6 0.7 2.9 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain WD40 PF00400.32 ETO23097.1 - 1.4e-05 25.7 4.5 0.00011 22.9 0.5 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat CRT10 PF08728.10 ETO23097.1 - 0.024 12.8 0.2 0.11 10.7 0.0 2.0 3 0 0 3 3 3 0 CRT10 ANAPC4_WD40 PF12894.7 ETO23097.1 - 0.051 13.9 0.1 9.3 6.6 0.0 3.0 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain AAA_18 PF13238.6 ETO23098.1 - 0.15 12.6 0.9 0.51 10.9 0.1 2.4 3 0 0 3 3 3 0 AAA domain RRM_1 PF00076.22 ETO23099.1 - 0.019 14.8 0.0 1.3 8.9 0.0 2.7 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PPP4R2 PF09184.11 ETO23099.1 - 1.9 8.0 23.5 0.24 11.0 18.6 1.8 2 0 0 2 2 2 0 PPP4R2 Tubulin PF00091.25 ETO23100.1 - 2.8e-37 128.9 0.7 5.3e-37 127.9 0.7 1.4 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Ureide_permease PF07168.11 ETO23100.1 - 0.0054 15.5 0.1 0.0068 15.2 0.1 1.1 1 0 0 1 1 1 1 Ureide permease Tim54 PF11711.8 ETO23100.1 - 0.024 13.4 0.7 0.03 13.1 0.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 SRP9-21 PF05486.12 ETO23101.1 - 0.16 12.4 1.2 21 5.6 0.1 3.3 3 0 0 3 3 3 0 Signal recognition particle 9 kDa protein (SRP9) EphA2_TM PF14575.6 ETO23101.1 - 0.84 10.6 2.5 3.3 8.7 0.0 2.9 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Orthoreo_P10 PF07204.11 ETO23102.1 - 0.051 13.5 0.9 0.098 12.6 0.4 1.7 2 0 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Ferlin_C PF16165.5 ETO23102.1 - 0.073 13.0 5.3 0.27 11.2 2.5 2.1 1 1 0 2 2 2 0 Ferlin C-terminus Phage_Gp23 PF10669.9 ETO23102.1 - 7 7.0 13.3 0.11 12.9 5.4 2.0 2 1 1 3 3 3 0 Protein gp23 (Bacteriophage A118) ABC_membrane PF00664.23 ETO23105.1 - 1.7e-08 34.5 10.0 5.7e-08 32.8 10.0 2.0 1 1 0 1 1 1 1 ABC transporter transmembrane region zf-C2H2 PF00096.26 ETO23106.1 - 3.7e-06 27.1 23.4 0.35 11.4 0.2 4.6 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO23106.1 - 0.00048 20.7 23.7 0.16 12.9 0.2 4.7 4 0 0 4 4 4 3 C2H2-type zinc finger FOXP-CC PF16159.5 ETO23106.1 - 0.017 15.8 10.0 2.6 8.7 0.8 3.9 3 0 0 3 3 3 0 FOXP coiled-coil domain Transpos_assoc PF13963.6 ETO23106.1 - 0.07 13.4 4.5 0.15 12.4 0.1 3.1 3 0 0 3 3 3 0 Transposase-associated domain IBR PF01485.21 ETO23106.1 - 0.23 11.7 5.0 0.62 10.3 0.1 2.9 2 1 0 2 2 2 0 IBR domain, a half RING-finger domain Glucos_trans_II PF14264.6 ETO23107.1 - 5.2 6.3 8.4 0.092 12.1 1.5 1.5 2 0 0 2 2 2 0 Glucosyl transferase GtrII Dynamitin PF04912.14 ETO23108.1 - 9.4e-38 130.5 6.6 1.1e-37 130.3 6.6 1.1 1 0 0 1 1 1 1 Dynamitin Occludin_ELL PF07303.13 ETO23108.1 - 0.0052 17.5 4.7 1.2 9.9 0.9 2.7 2 1 0 2 2 2 2 Occludin homology domain G-alpha PF00503.20 ETO23108.1 - 0.016 14.4 0.5 0.055 12.6 0.1 1.9 2 0 0 2 2 2 0 G-protein alpha subunit DUF2721 PF11026.8 ETO23108.1 - 0.02 14.7 2.7 4.9 7.0 0.0 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2721) ZapB PF06005.12 ETO23108.1 - 0.026 15.0 9.8 0.57 10.7 2.6 2.8 2 0 0 2 2 2 0 Cell division protein ZapB DUF2357 PF09823.9 ETO23108.1 - 0.027 13.7 4.0 0.29 10.3 0.3 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF2357) MapZ_EC1 PF18041.1 ETO23108.1 - 0.034 14.4 4.2 0.13 12.5 0.1 2.8 2 1 0 2 2 2 0 MapZ extracellular domain 1 BLOC1_2 PF10046.9 ETO23108.1 - 0.046 14.0 6.2 0.59 10.5 0.6 3.6 3 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4972 PF16342.5 ETO23108.1 - 0.073 12.8 2.0 0.2 11.3 0.4 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4972) DivIC PF04977.15 ETO23108.1 - 0.079 12.7 3.6 3.4 7.5 0.3 2.7 2 0 0 2 2 2 0 Septum formation initiator YlqD PF11068.8 ETO23108.1 - 0.11 12.9 5.4 0.086 13.2 0.7 2.4 2 0 0 2 2 2 0 YlqD protein CorA PF01544.18 ETO23108.1 - 0.12 11.7 4.3 0.16 11.3 0.9 2.5 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein TMPIT PF07851.13 ETO23108.1 - 0.15 11.3 3.8 0.65 9.2 0.3 2.2 2 0 0 2 2 2 0 TMPIT-like protein DASH_Dad3 PF08656.10 ETO23108.1 - 0.23 11.6 0.1 0.23 11.6 0.1 2.8 3 1 0 3 3 2 0 DASH complex subunit Dad3 DUF2203 PF09969.9 ETO23108.1 - 0.33 11.7 6.3 1.2 9.8 0.4 2.8 2 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) Fib_alpha PF08702.10 ETO23108.1 - 0.58 10.3 9.6 2.5 8.3 0.8 2.8 3 1 0 3 3 2 0 Fibrinogen alpha/beta chain family Allexi_40kDa PF05549.11 ETO23108.1 - 0.78 9.2 7.7 7.7 5.9 0.5 2.6 1 1 3 4 4 4 0 Allexivirus 40kDa protein FlxA PF14282.6 ETO23108.1 - 1.6 8.8 12.2 0.84 9.7 1.3 3.6 3 1 0 3 3 3 0 FlxA-like protein Exonuc_VII_L PF02601.15 ETO23108.1 - 4.4 6.8 8.3 48 3.4 8.2 2.1 1 1 0 1 1 1 0 Exonuclease VII, large subunit Uso1_p115_C PF04871.13 ETO23108.1 - 5.3 7.4 10.2 9.7 6.6 2.4 2.9 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Pro_3_hydrox_C PF05373.11 ETO23109.1 - 0.01 15.9 0.1 0.063 13.4 0.0 2.2 2 1 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal TipAS PF07739.13 ETO23109.1 - 0.013 16.1 4.2 0.042 14.4 0.5 2.2 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain nsp8 PF08717.10 ETO23109.1 - 0.03 14.2 2.5 0.23 11.3 0.5 2.1 2 0 0 2 2 2 0 nsp8 replicase CarD_CdnL_TRCF PF02559.16 ETO23109.1 - 0.052 14.2 2.0 9 7.1 0.1 2.5 2 1 0 2 2 2 0 CarD-like/TRCF domain Xpo1 PF08389.12 ETO23109.1 - 0.1 12.7 1.7 0.33 11.0 1.7 1.8 1 1 0 1 1 1 0 Exportin 1-like protein DctP PF03480.13 ETO23109.1 - 1.7 8.0 6.1 4.4 6.6 0.4 2.4 1 1 0 2 2 2 0 Bacterial extracellular solute-binding protein, family 7 HSCB_C PF07743.13 ETO23109.1 - 1.9 9.0 9.9 14 6.3 0.7 3.5 1 1 2 3 3 3 0 HSCB C-terminal oligomerisation domain Peroxin-22 PF12827.7 ETO23111.1 - 0.028 14.3 0.3 0.11 12.5 0.0 1.9 2 0 0 2 2 2 0 Peroxisomal biogenesis protein family RPEL PF02755.15 ETO23112.1 - 1.2e-16 59.8 20.7 1.1e-07 31.4 1.1 5.2 5 0 0 5 5 5 4 RPEL repeat APC_u15 PF16636.5 ETO23112.1 - 0.34 11.4 0.0 0.34 11.4 0.0 3.3 2 2 0 3 3 3 0 Unstructured region on APC between APC_crr regions 5 and 6 MetOD1 PF18546.1 ETO23112.1 - 0.36 10.8 2.0 1.8 8.5 1.9 2.1 1 1 1 2 2 2 0 Metanogen output domain 1 CREPT PF16566.5 ETO23112.1 - 0.55 10.4 17.9 2.7 8.1 2.5 3.3 3 1 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour Ribosomal_S20p PF01649.18 ETO23112.1 - 1.2 9.8 7.8 4.1 8.1 5.0 2.7 2 0 0 2 2 2 0 Ribosomal protein S20 RasGAP PF00616.19 ETO23113.1 - 0.021 14.5 1.4 0.074 12.7 1.4 2.0 1 1 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase CLN3 PF02487.17 ETO23114.1 - 0.004 16.2 4.5 0.004 16.2 4.5 2.0 1 1 1 2 2 2 1 CLN3 protein Hid1 PF12722.7 ETO23114.1 - 0.055 11.6 16.8 0.066 11.3 16.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MGC-24 PF05283.11 ETO23114.1 - 0.064 13.7 2.0 0.12 12.8 2.0 1.5 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin SLC12 PF03522.15 ETO23114.1 - 0.81 8.6 15.1 1.1 8.2 15.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF2151 PF10221.9 ETO23114.1 - 0.91 8.0 17.5 1.2 7.7 17.5 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator YjbH PF06082.11 ETO23114.1 - 1.5 7.5 10.9 1.8 7.3 10.9 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH DUF4778 PF16008.5 ETO23114.1 - 3.8 7.5 16.5 5.4 7.0 16.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4778) SAPS PF04499.15 ETO23114.1 - 5.7 5.6 18.2 7.1 5.3 18.2 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SID-1_RNA_chan PF13965.6 ETO23114.1 - 6.3 5.1 11.7 12 4.2 11.7 1.5 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 PH PF00169.29 ETO23116.1 - 2.5e-05 24.7 0.8 2.5e-05 24.7 0.8 2.1 2 1 0 2 2 2 1 PH domain Pkinase PF00069.25 ETO23116.1 - 0.0093 15.4 0.0 0.053 12.9 0.0 2.3 1 1 0 1 1 1 1 Protein kinase domain PH_6 PF15406.6 ETO23116.1 - 0.014 15.7 0.1 0.041 14.2 0.1 1.8 1 1 0 1 1 1 0 Pleckstrin homology domain PH_3 PF14593.6 ETO23116.1 - 0.053 13.6 1.2 0.2 11.7 1.2 2.1 1 1 0 1 1 1 0 PH domain Mucin PF01456.17 ETO23117.1 - 0.75 9.8 21.0 0.38 10.7 13.2 2.4 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF1143 PF06608.11 ETO23117.1 - 2.8 8.0 6.2 0.61 10.1 1.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1143) Nop14 PF04147.12 ETO23117.1 - 3.7 5.6 27.1 4.9 5.2 27.1 1.1 1 0 0 1 1 1 0 Nop14-like family Mito_carr PF00153.27 ETO23118.1 - 4e-25 87.5 4.0 2.5e-19 69.0 1.6 2.9 2 1 0 2 2 2 2 Mitochondrial carrier protein EII-Sor PF03609.14 ETO23118.1 - 0.035 13.5 0.5 0.53 9.7 0.1 2.1 2 0 0 2 2 2 0 PTS system sorbose-specific iic component Mito_carr PF00153.27 ETO23119.1 - 2.2e-29 101.2 1.7 2.6e-18 65.7 0.3 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein DUF4257 PF14074.6 ETO23119.1 - 0.014 15.6 0.0 0.027 14.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4257) MBOAT_2 PF13813.6 ETO23120.1 - 0.0047 17.2 1.5 0.0047 17.2 1.5 1.9 2 0 0 2 2 2 1 Membrane bound O-acyl transferase family DUF1242 PF06842.12 ETO23120.1 - 0.017 14.9 0.2 0.044 13.6 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1242) Hydrolase_4 PF12146.8 ETO23121.1 - 5.8e-06 25.8 0.2 0.042 13.1 0.0 2.6 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETO23121.1 - 1.3e-05 24.8 0.6 3.9e-05 23.2 0.2 2.0 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETO23121.1 - 0.0002 21.2 2.1 0.025 14.4 0.4 2.8 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Abhydrolase_6 PF12697.7 ETO23121.1 - 0.0043 17.7 0.0 0.53 10.8 0.0 2.3 2 0 0 2 2 2 1 Alpha/beta hydrolase family DLH PF01738.18 ETO23121.1 - 0.054 13.0 0.5 0.35 10.4 0.1 2.2 2 0 0 2 2 2 0 Dienelactone hydrolase family Abhydrolase_1 PF00561.20 ETO23121.1 - 0.071 12.7 2.4 0.87 9.2 0.0 2.6 3 0 0 3 3 3 0 alpha/beta hydrolase fold WD40 PF00400.32 ETO23122.1 - 5.1e-39 131.6 13.8 1.1e-05 26.0 0.4 7.3 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23122.1 - 2.1e-10 40.8 1.0 0.84 10.0 0.0 5.8 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO23122.1 - 3.5e-05 24.4 7.0 3.5e-05 24.4 7.0 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger DUF3475 PF11961.8 ETO23122.1 - 0.075 13.1 0.1 7.1 6.8 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3475) PRP9_N PF16958.5 ETO23122.1 - 0.19 11.7 12.9 0.52 10.3 12.9 1.7 1 0 0 1 1 1 0 Pre-mRNA-splicing factor PRP9 N-terminus XhlA PF10779.9 ETO23122.1 - 2.1 8.6 8.7 5.1 7.4 8.7 1.7 1 0 0 1 1 1 0 Haemolysin XhlA FA_desaturase PF00487.24 ETO23123.1 - 6e-24 85.2 22.3 1.2e-23 84.3 22.3 1.5 1 1 0 1 1 1 1 Fatty acid desaturase RhoGEF PF00621.20 ETO23124.1 - 2.7e-14 53.8 7.6 5.8e-14 52.7 5.5 2.4 2 1 0 2 2 2 1 RhoGEF domain PH PF00169.29 ETO23124.1 - 1.1e-08 35.5 0.3 1.1e-08 35.5 0.3 2.2 3 0 0 3 3 3 1 PH domain DUF1320 PF07030.12 ETO23124.1 - 0.15 12.2 0.0 16 5.6 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1320) DUF5379 PF17350.2 ETO23127.1 - 0.035 14.4 0.0 0.052 13.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5379) Sarcoglycan_2 PF05510.13 ETO23128.1 - 0.00074 18.4 0.1 0.00074 18.4 0.1 1.7 2 0 0 2 2 2 1 Sarcoglycan alpha/epsilon RhoGEF67_u1 PF16615.5 ETO23129.1 - 0.075 13.6 0.6 0.32 11.5 0.0 2.0 2 0 0 2 2 2 0 Unstructured region one on RhoGEF 6 and 7 Fringe PF02434.16 ETO23130.1 - 0.00014 21.4 0.0 0.00038 20.0 0.0 1.9 1 1 0 1 1 1 1 Fringe-like DUF4857 PF16149.5 ETO23130.1 - 0.045 13.0 0.1 0.068 12.4 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4857) RTT107_BRCT_5 PF16770.5 ETO23131.1 - 3.9e-09 36.3 0.4 1e-07 31.8 0.0 2.9 2 1 1 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT PF00533.26 ETO23131.1 - 2.6e-05 24.5 0.1 0.0036 17.7 0.0 2.8 2 0 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ETO23131.1 - 0.0002 21.6 0.1 0.12 12.7 0.1 3.2 3 0 0 3 3 3 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 ETO23131.1 - 0.00021 21.6 0.1 0.47 10.9 0.0 2.6 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain CDC45 PF02724.14 ETO23131.1 - 0.12 10.7 13.1 0.16 10.2 13.1 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO23131.1 - 0.28 10.4 2.0 0.31 10.2 1.3 1.6 2 0 0 2 2 2 0 ZIP Zinc transporter Astro_capsid_p PF12226.8 ETO23131.1 - 2.5 7.2 11.7 3.5 6.7 11.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Merozoite_SPAM PF07133.11 ETO23131.1 - 6.5 6.7 26.4 15 5.5 26.4 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) RXT2_N PF08595.11 ETO23132.1 - 0.018 15.0 3.4 0.027 14.5 3.4 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Sporozoite_P67 PF05642.11 ETO23132.1 - 0.03 12.4 3.1 0.034 12.3 3.1 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ETO23132.1 - 0.49 9.7 5.8 0.64 9.3 5.8 1.2 1 0 0 1 1 1 0 NOA36 protein LRS4 PF10422.9 ETO23132.1 - 0.74 9.3 6.6 1.3 8.6 6.6 1.4 1 1 0 1 1 1 0 Monopolin complex subunit LRS4 AIG1 PF04548.16 ETO23133.1 - 9.6e-09 34.9 0.0 1.5e-08 34.3 0.0 1.4 1 0 0 1 1 1 1 AIG1 family TelA PF05816.11 ETO23133.1 - 0.067 12.3 0.1 0.11 11.5 0.1 1.4 1 1 0 1 1 1 0 Toxic anion resistance protein (TelA) SeqA_N PF17206.3 ETO23133.1 - 0.17 11.2 0.0 0.17 11.2 0.0 1.9 2 0 0 2 2 2 0 SeqA protein N-terminal domain DUF1216 PF06746.11 ETO23134.1 - 0.0019 18.2 6.7 0.0024 17.9 6.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1216) Apolipoprotein PF01442.18 ETO23134.1 - 0.0075 16.2 0.8 0.013 15.4 0.8 1.3 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain Fib_alpha PF08702.10 ETO23134.1 - 0.062 13.5 9.7 0.053 13.7 8.4 1.5 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Bud13 PF09736.9 ETO23134.1 - 0.098 13.0 5.0 0.14 12.6 5.0 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex HMGL-like PF00682.19 ETO23134.1 - 0.13 11.8 0.8 0.15 11.6 0.8 1.1 1 0 0 1 1 1 0 HMGL-like DUF4996 PF16387.5 ETO23134.1 - 0.16 12.5 2.6 0.29 11.6 2.6 1.6 1 1 0 1 1 1 0 Domain of unknown function DUF3800 PF12686.7 ETO23134.1 - 0.26 11.9 2.6 0.36 11.5 2.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3800) DUF4485 PF14846.6 ETO23134.1 - 0.43 10.7 5.1 0.55 10.3 3.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4485) TMPIT PF07851.13 ETO23134.1 - 0.45 9.7 7.7 0.55 9.4 7.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 ETO23134.1 - 5.8 7.0 9.7 11 6.1 9.4 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Macoilin PF09726.9 ETO23136.1 - 0.32 9.5 9.4 0.36 9.3 9.4 1.0 1 0 0 1 1 1 0 Macoilin family Pyr_redox_2 PF07992.14 ETO23137.1 - 1.6e-08 34.1 0.0 3.9e-08 32.9 0.0 1.5 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Acetyltransf_1 PF00583.25 ETO23139.1 - 1.6e-09 38.0 0.0 2.6e-09 37.3 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO23139.1 - 7e-08 32.5 0.0 1.2e-07 31.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO23139.1 - 2.7e-07 30.9 0.3 6.7e-07 29.6 0.1 1.7 2 1 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO23139.1 - 9.9e-07 28.7 0.0 2.5e-06 27.3 0.0 1.7 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ETO23139.1 - 0.00053 20.7 0.0 0.00095 19.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain GNAT_acetyltran PF12746.7 ETO23139.1 - 0.00055 19.6 0.0 0.001 18.7 0.0 1.4 1 1 0 1 1 1 1 GNAT acetyltransferase Acetyltransf_15 PF17013.5 ETO23139.1 - 0.00097 18.7 0.1 0.0015 18.1 0.1 1.4 1 0 0 1 1 1 1 Putative acetyl-transferase Acetyltransf_9 PF13527.7 ETO23139.1 - 0.0012 18.9 0.0 0.0069 16.5 0.0 2.0 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain 4HB_MCP_1 PF12729.7 ETO23139.1 - 0.066 12.8 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Acetyltransf_8 PF13523.6 ETO23139.1 - 0.15 11.7 0.0 0.27 10.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Cation_efflux PF01545.21 ETO23140.1 - 1.1e-23 84.0 14.5 1.4e-23 83.7 14.5 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETO23140.1 - 2.9e-08 33.7 2.4 5.3e-08 32.9 2.4 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter SLATT_1 PF18181.1 ETO23140.1 - 0.96 9.4 5.3 2.5 8.0 0.2 2.9 2 1 1 3 3 3 0 SMODS and SLOG-associating 2TM effector domain 1 DUF92 PF01940.16 ETO23140.1 - 1.2 8.5 4.4 0.47 9.8 1.3 1.8 2 1 0 2 2 2 0 Integral membrane protein DUF92 zf-RanBP PF00641.18 ETO23141.1 - 0.0021 17.3 1.3 0.0021 17.3 1.3 2.6 2 1 0 2 2 2 1 Zn-finger in Ran binding protein and others PhnA_Zn_Ribbon PF08274.12 ETO23141.1 - 0.15 12.0 0.8 0.15 12.0 0.8 2.9 3 0 0 3 3 3 0 PhnA Zinc-Ribbon CAP_GLY PF01302.25 ETO23142.1 - 1e-16 60.7 2.4 1.5e-15 57.0 0.4 2.4 2 0 0 2 2 2 2 CAP-Gly domain B56 PF01603.20 ETO23143.1 - 1.3e-62 212.1 9.6 1e-61 209.2 9.6 2.1 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DUF3439 PF11921.8 ETO23143.1 - 7.8 6.5 11.6 0.27 11.2 3.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Voltage_CLC PF00654.20 ETO23144.1 - 5.7e-53 180.4 16.1 5.7e-53 180.4 16.1 2.3 1 1 1 2 2 2 2 Voltage gated chloride channel DUF5134 PF17197.4 ETO23144.1 - 0.0081 16.1 0.7 0.017 15.0 0.2 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF5134) DUF3311 PF11755.8 ETO23144.1 - 0.33 10.9 0.0 0.33 10.9 0.0 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3311) PRIMA1 PF16101.5 ETO23144.1 - 0.36 10.9 5.5 0.29 11.2 2.1 2.4 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 Laminin_G_3 PF13385.6 ETO23145.1 - 0.0002 21.6 0.0 0.00064 19.9 0.0 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3337 PF11816.8 ETO23145.1 - 0.035 14.0 0.8 0.14 12.1 0.8 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) Drc1-Sld2 PF11719.8 ETO23145.1 - 2.3 7.7 15.3 0.52 9.8 10.6 2.3 2 0 0 2 2 2 0 DNA replication and checkpoint protein EF-hand_8 PF13833.6 ETO23147.1 - 1.9e-16 59.6 5.4 1.6e-08 34.3 0.4 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 ETO23147.1 - 1.5e-15 57.4 4.5 1.1e-07 32.2 0.6 2.6 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO23147.1 - 1.9e-15 55.2 7.3 5.5e-08 31.8 0.3 3.5 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO23147.1 - 3.4e-12 45.2 4.5 2.7e-06 26.9 0.1 3.6 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO23147.1 - 2.9e-09 36.0 3.6 2.2e-05 23.7 0.2 2.8 2 0 0 2 2 2 2 EF hand TerB PF05099.13 ETO23147.1 - 0.00085 19.3 0.2 0.0052 16.7 0.0 2.1 1 1 2 3 3 3 1 Tellurite resistance protein TerB UPF0154 PF03672.13 ETO23147.1 - 0.013 15.5 0.0 0.053 13.5 0.0 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 ETO23147.1 - 0.018 14.9 2.2 0.73 9.8 0.1 2.5 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand T6PP_N PF18572.1 ETO23147.1 - 0.025 14.4 0.4 0.046 13.5 0.4 1.6 1 0 0 1 1 1 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain EF-hand_9 PF14658.6 ETO23147.1 - 0.093 13.1 0.1 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain DUF1722 PF08349.11 ETO23147.1 - 0.13 12.5 0.0 0.27 11.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1722) SurA_N_2 PF13623.6 ETO23147.1 - 0.14 12.0 1.5 1.8 8.4 0.3 2.6 1 1 2 3 3 3 0 SurA N-terminal domain PUB PF09409.10 ETO23148.1 - 9.8e-31 105.5 0.5 6.6e-12 45.2 0.0 3.3 3 0 0 3 3 3 3 PUB domain Keratin_matx PF04579.12 ETO23148.1 - 0.16 12.3 0.0 0.26 11.6 0.0 1.4 1 0 0 1 1 1 0 Keratin, high-sulphur matrix protein Sina PF03145.16 ETO23149.1 - 2.2e-06 27.8 4.3 2.2e-06 27.8 4.3 1.8 2 0 0 2 2 2 1 Seven in absentia protein family zf-RING_5 PF14634.6 ETO23149.1 - 0.018 15.0 11.0 0.059 13.3 11.0 2.0 1 0 0 1 1 1 0 zinc-RING finger domain TRAF6_Z2 PF18048.1 ETO23149.1 - 0.035 14.2 2.1 1.9 8.6 0.3 2.5 2 0 0 2 2 2 0 TNF receptor-associated factor 6 zinc finger 2 Endonuc-BsobI PF09194.10 ETO23150.1 - 0.075 12.2 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 Restriction endonuclease BsobI HpaP PF09483.10 ETO23150.1 - 0.085 13.1 0.0 0.21 11.8 0.0 1.6 1 0 0 1 1 1 0 Type III secretion protein (HpaP) REV1_C PF16727.5 ETO23151.1 - 0.024 15.0 0.6 0.55 10.6 0.2 2.9 2 0 0 2 2 2 0 DNA repair protein REV1 C-terminal domain Importin_rep_4 PF18808.1 ETO23151.1 - 1.8 8.9 9.6 0.78 10.1 0.2 3.2 2 0 0 2 2 2 0 Importin repeat HTH_1 PF00126.27 ETO23152.1 - 0.026 14.4 0.2 0.081 12.9 0.1 1.9 2 0 0 2 2 2 0 Bacterial regulatory helix-turn-helix protein, lysR family Mannosyl_trans3 PF11051.8 ETO23153.1 - 4e-06 26.4 0.1 4.3e-06 26.3 0.1 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Glyoxalase PF00903.25 ETO23155.1 - 1.2e-16 61.1 0.1 1.8e-16 60.5 0.1 1.2 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ETO23155.1 - 7e-05 23.1 0.0 0.00012 22.3 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily SAP130_C PF16014.5 ETO23155.1 - 0.01 15.0 0.0 0.013 14.6 0.0 1.1 1 0 0 1 1 1 0 Histone deacetylase complex subunit SAP130 C-terminus MutS_IV PF05190.18 ETO23155.1 - 0.021 15.2 0.1 0.044 14.1 0.1 1.5 1 0 0 1 1 1 0 MutS family domain IV Glyoxalase_3 PF13468.6 ETO23155.1 - 0.15 12.2 0.1 0.25 11.4 0.1 1.6 2 1 0 2 2 2 0 Glyoxalase-like domain Bee_toxin PF17454.2 ETO23156.1 - 0.72 9.9 8.9 0.22 11.6 5.4 1.9 2 1 0 2 2 2 0 Honey bee toxin CN_hydrolase PF00795.22 ETO23157.1 - 1.3e-45 155.8 0.0 1.6e-45 155.5 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase TORC_M PF12885.7 ETO23158.1 - 0.066 13.1 5.1 0.24 11.3 4.7 2.1 1 1 0 1 1 1 0 Transducer of regulated CREB activity middle domain zf-C2H2_12 PF18658.1 ETO23158.1 - 0.069 12.7 0.1 0.15 11.7 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger C2H2-type Mob1_phocein PF03637.17 ETO23159.1 - 2.3e-36 125.4 1.4 8.3e-36 123.5 1.4 1.7 1 1 0 1 1 1 1 Mob1/phocein family Acyl-thio_N PF12590.8 ETO23161.1 - 0.17 12.4 0.7 0.34 11.5 0.1 1.7 2 0 0 2 2 2 0 Acyl-ATP thioesterase GREB1 PF15782.5 ETO23161.1 - 1 6.4 6.5 1.3 6.1 6.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4281 PF14108.6 ETO23162.1 - 0.08 13.3 0.2 0.2 12.0 0.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4281) U-box PF04564.15 ETO23163.1 - 3.5e-21 75.2 0.1 7e-21 74.2 0.1 1.5 1 0 0 1 1 1 1 U-box domain zf-Nse PF11789.8 ETO23163.1 - 0.00037 20.3 0.1 0.00082 19.1 0.1 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit Zip PF02535.22 ETO23163.1 - 0.0012 18.1 0.4 0.0016 17.7 0.4 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter DDHD PF02862.17 ETO23163.1 - 0.003 17.8 0.7 0.0039 17.4 0.7 1.2 1 0 0 1 1 1 1 DDHD domain AAR2 PF05282.11 ETO23163.1 - 0.011 15.1 5.5 0.018 14.5 5.5 1.3 1 0 0 1 1 1 0 AAR2 protein Pox_Ag35 PF03286.14 ETO23163.1 - 0.019 14.7 6.7 0.032 14.0 6.7 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein zf-RING_UBOX PF13445.6 ETO23163.1 - 0.023 14.7 0.0 0.053 13.5 0.0 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Sporozoite_P67 PF05642.11 ETO23163.1 - 0.037 12.1 0.1 0.047 11.8 0.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Secretin_N_2 PF07655.13 ETO23163.1 - 0.066 13.8 7.2 0.15 12.6 7.2 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain HORMA PF02301.18 ETO23163.1 - 0.12 11.9 10.6 0.35 10.4 9.3 2.3 1 1 1 2 2 2 0 HORMA domain DUF2981 PF11200.8 ETO23163.1 - 0.17 11.6 1.9 0.3 10.8 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) CPSF100_C PF13299.6 ETO23163.1 - 0.18 12.0 4.5 0.28 11.3 4.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal V_ATPase_I PF01496.19 ETO23163.1 - 0.2 9.5 11.2 0.28 9.1 11.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Gly-zipper_Omp PF13488.6 ETO23163.1 - 0.22 11.5 22.2 1.1 9.3 22.2 1.9 1 1 0 1 1 1 0 Glycine zipper Presenilin PF01080.17 ETO23163.1 - 0.3 9.8 10.0 0.49 9.1 10.0 1.2 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 ETO23163.1 - 0.39 9.5 2.8 0.67 8.7 2.8 1.4 1 0 0 1 1 1 0 HCO3- transporter family Tom22 PF04281.13 ETO23163.1 - 0.47 10.2 7.3 2 8.2 5.6 2.3 1 1 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 DUF2076 PF09849.9 ETO23163.1 - 1.5 8.8 11.7 2.2 8.3 11.7 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) NOA36 PF06524.12 ETO23163.1 - 2.1 7.6 11.9 3.2 7.0 11.9 1.3 1 0 0 1 1 1 0 NOA36 protein Gly-zipper_YMGG PF13441.6 ETO23163.1 - 2.9 7.7 20.8 13 5.6 20.8 1.9 1 1 0 1 1 1 0 YMGG-like Gly-zipper ALMT PF11744.8 ETO23163.1 - 3.2 6.5 11.8 4.5 6.0 11.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Rick_17kDa_Anti PF05433.15 ETO23163.1 - 3.9 7.4 18.7 7.4 6.5 18.7 1.5 1 0 0 1 1 1 0 Glycine zipper 2TM domain WD40 PF00400.32 ETO23164.1 - 1.1e-32 111.5 11.6 3.7e-08 33.9 0.0 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23164.1 - 1.1e-14 54.5 0.3 0.021 15.1 0.0 4.7 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23164.1 - 7.8e-09 34.9 0.6 0.21 10.5 0.0 4.4 1 1 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO23164.1 - 0.00084 19.3 0.3 0.47 10.3 0.1 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A DUF5570 PF17731.1 ETO23164.1 - 0.0031 17.6 0.5 3 7.9 0.2 3.7 2 2 3 5 5 5 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO23164.1 - 0.02 13.6 0.1 7.1 5.3 0.0 3.0 2 2 0 2 2 2 0 Nup133 N terminal like Spc29 PF17082.5 ETO23164.1 - 0.18 11.6 0.0 0.3 10.9 0.0 1.4 1 0 0 1 1 1 0 Spindle Pole Component 29 PD40 PF07676.12 ETO23164.1 - 0.32 11.0 2.0 10 6.2 0.0 3.2 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Cyanate_lyase PF02560.14 ETO23165.1 - 1e-28 98.9 0.0 1.8e-28 98.2 0.0 1.4 1 0 0 1 1 1 1 Cyanate lyase C-terminal domain HTH_3 PF01381.22 ETO23165.1 - 0.0064 16.5 0.0 0.013 15.5 0.0 1.5 1 0 0 1 1 1 1 Helix-turn-helix DUF2316 PF10078.9 ETO23165.1 - 0.0068 16.6 0.0 0.014 15.6 0.0 1.5 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2316) HTH_19 PF12844.7 ETO23165.1 - 0.046 13.7 0.2 0.095 12.7 0.1 1.7 2 0 0 2 2 2 0 Helix-turn-helix domain HTH_Mga PF08280.11 ETO23165.1 - 0.058 13.4 0.3 0.22 11.5 0.0 2.1 2 0 0 2 2 2 0 M protein trans-acting positive regulator (MGA) HTH domain FYVE PF01363.21 ETO23166.1 - 5.9e-09 35.9 12.2 5.9e-09 35.9 12.2 2.6 3 0 0 3 3 3 1 FYVE zinc finger DUF4196 PF13846.6 ETO23166.1 - 0.0042 17.3 6.0 0.0042 17.3 6.0 4.0 2 1 1 3 3 3 2 Domain of unknown function (DUF4196) RCC1 PF00415.18 ETO23168.1 - 2.5e-10 40.8 6.6 0.00074 20.1 0.0 5.5 5 1 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO23168.1 - 6.3e-07 29.0 14.9 0.0074 16.1 0.0 5.2 5 0 0 5 5 5 3 Regulator of chromosome condensation (RCC1) repeat Apo-CII PF05355.11 ETO23169.1 - 0.28 11.3 2.4 16 5.7 0.1 2.4 2 0 0 2 2 2 0 Apolipoprotein C-II DUF563 PF04577.14 ETO23171.1 - 9.1e-23 81.5 0.0 1.1e-22 81.2 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF563) RED_N PF07808.13 ETO23172.1 - 4.8e-17 62.3 30.0 6.4e-14 52.1 10.8 6.2 3 1 1 4 4 4 2 RED-like protein N-terminal region Prothymosin PF03247.14 ETO23173.1 - 0.013 15.9 24.1 0.013 15.9 24.1 3.1 1 1 2 3 3 3 0 Prothymosin/parathymosin family Sld3_N PF18523.1 ETO23174.1 - 5.8 7.1 7.9 4.5 7.4 0.4 3.1 3 0 0 3 3 3 0 Sld3 N-terminal domain FerA PF08165.11 ETO23175.1 - 0.068 13.1 0.3 14 5.7 0.0 3.2 2 0 0 2 2 2 0 FerA (NUC095) domain ANAPC4_WD40 PF12894.7 ETO23176.1 - 0.042 14.2 0.0 1.8 8.9 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RICTOR_N PF14664.6 ETO23178.1 - 8.3e-07 28.3 0.0 0.013 14.5 0.0 2.1 2 0 0 2 2 2 2 Rapamycin-insensitive companion of mTOR, N-term TAP42 PF04177.12 ETO23179.1 - 5.7e-14 52.0 0.1 6.4e-14 51.8 0.1 1.0 1 0 0 1 1 1 1 TAP42-like family UL11 PF11094.8 ETO23179.1 - 0.48 10.4 2.3 2.7 7.9 0.1 2.7 3 0 0 3 3 3 0 Membrane-associated tegument protein RNA_pol_Rpb2_3 PF04565.16 ETO23180.1 - 0.079 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 RNA polymerase Rpb2, domain 3 ChW PF07538.11 ETO23180.1 - 0.16 11.9 1.5 13 5.8 0.0 2.5 2 0 0 2 2 2 0 Clostridial hydrophobic W RRM_1 PF00076.22 ETO23181.1 - 1.3e-17 63.4 0.0 2.3e-17 62.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO23181.1 - 0.0077 15.8 0.0 0.031 13.9 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO23181.1 - 0.042 13.9 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 RNA binding domain CDC45 PF02724.14 ETO23183.1 - 1.8 6.7 10.4 2.1 6.5 10.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_repr_REX1B PF14966.6 ETO23184.1 - 9.8e-09 35.8 4.8 1.2e-08 35.5 4.8 1.1 1 0 0 1 1 1 1 DNA repair REX1-B DUF1955 PF09205.10 ETO23184.1 - 0.015 15.1 1.7 0.018 14.8 1.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF1955) Ppx-GppA PF02541.16 ETO23184.1 - 0.065 12.7 1.0 0.071 12.5 1.0 1.1 1 0 0 1 1 1 0 Ppx/GppA phosphatase family RNB PF00773.19 ETO23185.1 - 2.3e-39 135.6 0.9 4.3e-39 134.7 0.0 1.9 2 0 0 2 2 2 1 RNB domain OB_Dis3 PF17849.1 ETO23185.1 - 5.4e-07 29.6 0.0 1.3e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) DUF5308 PF17233.2 ETO23186.1 - 0.0064 16.7 0.1 0.011 15.9 0.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5308) PRTP PF01366.18 ETO23186.1 - 0.017 13.2 4.4 0.024 12.7 4.4 1.1 1 0 0 1 1 1 0 Herpesvirus processing and transport protein DDHD PF02862.17 ETO23186.1 - 0.1 12.8 3.4 0.16 12.1 3.4 1.4 1 0 0 1 1 1 0 DDHD domain ELM2 PF01448.24 ETO23186.1 - 0.12 13.2 2.2 0.9 10.3 2.2 2.5 1 1 0 1 1 1 0 ELM2 domain RNA_pol_Rpc4 PF05132.14 ETO23186.1 - 0.42 11.0 8.9 1 9.8 8.9 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 GAGA_bind PF06217.12 ETO23186.1 - 0.45 10.7 11.1 0.74 10.0 11.1 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family RNA_polI_A34 PF08208.11 ETO23186.1 - 0.51 10.4 20.5 0.87 9.6 20.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF4637 PF15470.6 ETO23186.1 - 0.54 10.0 11.2 1.1 9.0 11.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CPSF100_C PF13299.6 ETO23186.1 - 0.76 9.9 8.0 1.6 8.9 8.0 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RR_TM4-6 PF06459.12 ETO23186.1 - 0.84 9.4 17.2 1.5 8.6 17.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CENP-B_dimeris PF09026.10 ETO23186.1 - 1.6 9.2 8.5 4.1 7.8 8.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain NOA36 PF06524.12 ETO23186.1 - 1.7 7.9 11.8 2.5 7.3 11.8 1.2 1 0 0 1 1 1 0 NOA36 protein SdpI PF13630.6 ETO23186.1 - 2.9 8.1 7.0 0.63 10.2 3.3 1.8 2 0 0 2 2 2 0 SdpI/YhfL protein family CDC45 PF02724.14 ETO23186.1 - 3.3 5.9 15.2 4.9 5.3 15.2 1.2 1 0 0 1 1 1 0 CDC45-like protein TFB6 PF17110.5 ETO23186.1 - 3.4 7.4 9.5 7 6.4 9.5 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH RPN2_C PF18004.1 ETO23186.1 - 5.3 7.0 21.2 11 5.9 21.2 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Connexin PF00029.19 ETO23186.1 - 7.7 6.2 10.0 20 4.9 10.0 1.7 1 0 0 1 1 1 0 Connexin FAM60A PF15396.6 ETO23186.1 - 7.9 6.4 10.9 18 5.3 10.9 1.7 1 0 0 1 1 1 0 Protein Family FAM60A EIIBC-GUT_N PF03612.14 ETO23186.1 - 9.7 5.9 7.9 19 5.0 7.9 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus PAP_assoc PF03828.19 ETO23190.1 - 1.5e-13 50.7 0.2 3e-13 49.8 0.2 1.5 1 0 0 1 1 1 1 Cid1 family poly A polymerase Presenilin PF01080.17 ETO23191.1 - 0.032 13.0 1.9 0.046 12.5 1.9 1.2 1 0 0 1 1 1 0 Presenilin SGT1 PF07093.11 ETO23191.1 - 0.075 11.5 9.9 0.1 11.0 9.9 1.2 1 0 0 1 1 1 0 SGT1 protein BIRC6 PF12356.8 ETO23191.1 - 0.11 11.9 0.1 0.11 11.9 0.1 2.1 1 1 1 2 2 2 0 Baculoviral IAP repeat-containing protein 6 PPP4R2 PF09184.11 ETO23191.1 - 1.7 8.2 20.7 2.2 7.8 20.7 1.1 1 0 0 1 1 1 0 PPP4R2 CLASP_N PF12348.8 ETO23193.1 - 0.04 13.5 0.0 0.068 12.7 0.0 1.4 1 0 0 1 1 1 0 CLASP N terminal Glyco_transf_18 PF15024.6 ETO23194.1 - 1.7e-10 40.2 1.0 6.4e-10 38.2 0.1 2.2 2 1 0 2 2 2 1 Glycosyltransferase family 18 MHC_I_3 PF16497.5 ETO23194.1 - 0.03 13.8 0.3 0.065 12.7 0.3 1.5 1 0 0 1 1 1 0 MHC-I family domain DUF3504 PF12012.8 ETO23195.1 - 0.032 14.1 4.2 0.043 13.7 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Kelch_6 PF13964.6 ETO23196.1 - 0.00034 20.8 1.8 0.32 11.4 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO23196.1 - 0.00043 20.1 1.0 0.057 13.4 0.0 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO23196.1 - 0.0021 18.0 0.1 0.0021 18.0 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO23196.1 - 0.016 14.8 1.0 0.063 12.9 0.2 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO23196.1 - 0.15 12.1 0.3 0.15 12.1 0.3 2.9 4 0 0 4 4 4 0 Kelch motif Cofilin_ADF PF00241.20 ETO23197.1 - 4.3e-05 23.3 1.0 0.66 9.8 0.0 3.7 3 1 0 3 3 3 3 Cofilin/tropomyosin-type actin-binding protein Presenilin PF01080.17 ETO23197.1 - 4.3 6.0 5.5 5.5 5.7 5.5 1.1 1 0 0 1 1 1 0 Presenilin Annexin PF00191.20 ETO23198.1 - 8.2e-07 29.0 0.0 1.8e-06 27.9 0.0 1.7 1 0 0 1 1 1 1 Annexin EF-hand_1 PF00036.32 ETO23198.1 - 3.6e-05 23.0 0.0 0.00017 20.9 0.0 2.2 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO23198.1 - 0.0044 16.9 0.0 0.024 14.5 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ETO23198.1 - 0.0071 15.8 0.6 0.036 13.6 0.1 2.4 2 0 0 2 2 2 1 EF hand Init_tRNA_PT PF04179.12 ETO23198.1 - 0.0087 16.3 0.0 0.03 14.6 0.0 1.8 1 1 1 2 2 2 1 Rit1 DUSP-like domain EF-hand_7 PF13499.6 ETO23198.1 - 0.014 15.9 0.1 0.036 14.5 0.0 1.8 2 0 0 2 2 2 0 EF-hand domain pair DUF5339 PF17274.2 ETO23198.1 - 0.43 11.5 3.4 2.3 9.1 0.4 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5339) Annexin PF00191.20 ETO23199.1 - 5.1e-26 90.5 9.3 2.1e-12 46.9 0.1 5.8 5 1 0 5 5 5 4 Annexin Creatinase_N PF01321.18 ETO23199.1 - 0.023 15.4 0.2 0.061 14.0 0.0 1.7 2 0 0 2 2 2 0 Creatinase/Prolidase N-terminal domain hDGE_amylase PF14701.6 ETO23199.1 - 0.06 12.4 5.0 0.12 11.5 5.0 1.4 1 0 0 1 1 1 0 Glycogen debranching enzyme, glucanotransferase domain Erythro_esteras PF05139.14 ETO23199.1 - 0.068 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Erythromycin esterase Interfer-bind PF09294.10 ETO23199.1 - 0.83 10.0 5.0 0.67 10.3 0.8 2.8 2 1 0 3 3 3 0 Interferon-alpha/beta receptor, fibronectin type III MCM_bind PF09739.9 ETO23200.1 - 1.9 6.9 7.2 2.6 6.4 7.2 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Glyco_hydro_32C PF08244.12 ETO23202.1 - 1.1e-21 77.5 0.1 1.4e-21 77.1 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 32 C terminal UCH PF00443.29 ETO23203.1 - 2.1e-12 47.1 3.7 4e-12 46.2 3.7 1.6 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SUIM_assoc PF16619.5 ETO23203.1 - 0.039 14.0 3.3 0.039 14.0 3.3 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF445 PF04286.12 ETO23203.1 - 0.055 13.3 0.8 0.065 13.0 0.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF445) Sulfotransfer_3 PF13469.6 ETO23203.1 - 0.078 13.4 1.4 0.15 12.4 0.1 1.9 2 0 0 2 2 2 0 Sulfotransferase family Orf78 PF06024.12 ETO23204.1 - 0.048 14.0 0.8 0.048 14.0 0.8 2.7 2 1 1 3 3 3 0 Orf78 (ac78) NPR3 PF03666.13 ETO23204.1 - 0.28 9.9 1.1 0.38 9.5 1.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1129 PF06570.11 ETO23204.1 - 0.59 9.6 2.6 4.9 6.6 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Secretin_N_2 PF07655.13 ETO23204.1 - 1.4 9.5 9.7 2.3 8.8 9.7 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Lzipper-MIP1 PF14389.6 ETO23207.1 - 0.34 11.2 3.4 1.4 9.3 3.4 2.0 1 1 0 1 1 1 0 Leucine-zipper of ternary complex factor MIP1 MtN3_slv PF03083.16 ETO23208.1 - 1.2e-17 63.7 0.2 9e-16 57.7 0.0 2.3 2 1 0 2 2 2 2 Sugar efflux transporter for intercellular exchange TAT_signal PF10518.9 ETO23208.1 - 0.32 10.9 5.0 0.72 9.8 5.0 1.6 1 0 0 1 1 1 0 TAT (twin-arginine translocation) pathway signal sequence A_deaminase PF00962.22 ETO23209.1 - 8.6e-19 68.0 0.0 1.2e-17 64.3 0.0 2.0 1 1 0 1 1 1 1 Adenosine/AMP deaminase ING PF12998.7 ETO23210.1 - 0.0025 18.4 3.9 0.0025 18.4 3.9 2.6 2 1 0 2 2 2 1 Inhibitor of growth proteins N-terminal histone-binding LuxC PF05893.14 ETO23210.1 - 0.016 14.3 0.1 0.032 13.3 0.1 1.5 1 0 0 1 1 1 0 Acyl-CoA reductase (LuxC) PocR PF10114.9 ETO23210.1 - 0.62 9.8 3.5 1.8 8.3 0.1 2.5 1 1 1 2 2 2 0 Sensory domain found in PocR PDE4_UCR PF18100.1 ETO23210.1 - 2.1 9.0 10.5 0.059 14.0 1.9 2.5 1 1 1 2 2 2 0 Phosphodiesterase 4 upstream conserved regions (UCR) Caldesmon PF02029.15 ETO23210.1 - 3.3 6.4 34.7 4.6 5.9 34.7 1.1 1 0 0 1 1 1 0 Caldesmon NOA36 PF06524.12 ETO23210.1 - 5 6.4 16.7 12 5.1 16.7 1.7 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 ETO23210.1 - 8.8 5.4 5.5 11 5.2 5.5 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Otopetrin PF03189.13 ETO23211.1 - 5.3 5.7 8.0 2.3 6.9 6.2 1.3 1 1 0 1 1 1 0 Otopetrin zf-C3HC4_3 PF13920.6 ETO23212.1 - 2.7e-10 39.9 4.1 4.4e-10 39.3 4.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO23212.1 - 4.9e-05 23.1 6.4 9e-05 22.3 6.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 V_ATPase_I PF01496.19 ETO23212.1 - 0.02 12.8 2.0 0.022 12.7 2.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zf-RING_5 PF14634.6 ETO23212.1 - 0.025 14.5 6.1 0.048 13.6 6.1 1.5 1 0 0 1 1 1 0 zinc-RING finger domain Mgr1 PF08602.10 ETO23212.1 - 0.52 9.1 5.8 0.97 8.2 5.8 1.4 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Caudo_TAP PF02413.17 ETO23212.1 - 3.4 7.8 9.2 4.9 7.3 7.2 2.2 1 1 0 2 2 2 0 Caudovirales tail fibre assembly protein, lambda gpK 7tm_3 PF00003.22 ETO23214.1 - 5.1e-32 111.5 24.8 5.1e-32 111.5 24.8 1.5 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR Chlam_PMP PF02415.17 ETO23214.1 - 0.00018 21.8 57.8 1.2 9.8 0.1 11.4 12 0 0 12 12 12 6 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Cytomega_UL20A PF05984.12 ETO23214.1 - 0.34 11.2 2.9 21 5.5 0.0 3.2 2 0 0 2 2 2 0 Cytomegalovirus UL20A protein ZF-HD_dimer PF04770.12 ETO23214.1 - 1.7 9.0 7.1 12 6.3 0.6 4.0 3 1 1 4 4 4 0 ZF-HD protein dimerisation region Kelch_4 PF13418.6 ETO23215.1 - 0.0044 17.0 5.7 6.9 6.8 0.0 5.0 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO23215.1 - 0.0097 15.5 3.9 5.5 6.7 0.0 5.2 5 0 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO23215.1 - 0.038 14.0 1.3 12 6.0 0.1 4.0 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO23215.1 - 0.044 14.1 5.7 22 5.5 0.2 4.9 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO23215.1 - 0.094 13.0 5.7 5.7 7.4 0.0 4.4 5 0 0 5 5 5 0 Kelch motif SIP1 PF04938.12 ETO23216.1 - 6.3e-43 147.0 1.2 8e-43 146.7 1.2 1.0 1 0 0 1 1 1 1 Survival motor neuron (SMN) interacting protein 1 (SIP1) LisH_2 PF16045.5 ETO23217.1 - 0.015 14.3 0.1 0.042 12.9 0.1 1.8 1 0 0 1 1 1 0 LisH DUF4549 PF15082.6 ETO23217.1 - 1 9.2 6.0 0.22 11.3 1.2 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4549) cNMP_binding PF00027.29 ETO23219.1 - 4.3e-15 55.5 0.0 5.8e-08 32.7 0.0 2.2 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain ADP_ribosyl_GH PF03747.14 ETO23221.1 - 4.5e-30 105.4 0.0 6.4e-30 104.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Clathrin_H_link PF13838.6 ETO23221.1 - 0.073 13.0 1.0 0.25 11.3 1.0 1.9 1 0 0 1 1 1 0 Clathrin-H-link SUIM_assoc PF16619.5 ETO23221.1 - 0.37 10.9 7.2 0.62 10.2 4.7 2.4 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF4769 PF15992.5 ETO23222.1 - 0.13 12.1 4.3 0.13 12.0 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4769) UPF0524 PF15823.5 ETO23222.1 - 9.7 5.5 13.2 13 5.1 13.1 1.3 1 1 0 1 1 1 0 UPF0524 of C3orf70 Podoplanin PF05808.11 ETO23223.1 - 0.006 16.7 6.4 0.012 15.8 0.2 2.3 2 0 0 2 2 2 1 Podoplanin CYYR1 PF10873.8 ETO23223.1 - 0.011 16.1 0.1 0.03 14.8 0.1 1.7 1 0 0 1 1 1 0 Cysteine and tyrosine-rich protein 1 Vel1p PF10339.9 ETO23223.1 - 0.028 13.8 0.0 0.053 12.9 0.0 1.6 1 0 0 1 1 1 0 Yeast-specific zinc responsive Amnionless PF14828.6 ETO23223.1 - 0.046 12.6 0.0 0.074 11.9 0.0 1.3 1 0 0 1 1 1 0 Amnionless Kelch_1 PF01344.25 ETO23223.1 - 0.051 13.2 1.1 7.2 6.3 0.1 2.7 2 0 0 2 2 2 0 Kelch motif MAP17 PF15807.5 ETO23223.1 - 0.056 13.7 0.1 0.11 12.7 0.1 1.5 1 1 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Kelch_3 PF13415.6 ETO23223.1 - 0.058 13.7 0.0 3.7 7.9 0.0 2.5 2 0 0 2 2 2 0 Galactose oxidase, central domain MLANA PF14991.6 ETO23223.1 - 0.073 13.3 0.0 0.13 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A Kelch_5 PF13854.6 ETO23223.1 - 0.078 13.0 0.3 1 9.4 0.1 2.7 3 0 0 3 3 3 0 Kelch motif Syndecan PF01034.20 ETO23223.1 - 0.12 12.3 1.2 0.18 11.7 0.1 1.8 2 0 0 2 2 2 0 Syndecan domain MtrF PF09472.10 ETO23223.1 - 0.36 10.3 3.0 0.71 9.3 3.0 1.4 1 0 0 1 1 1 0 Tetrahydromethanopterin S-methyltransferase, F subunit (MtrF) MCR_alpha PF02249.17 ETO23224.1 - 0.21 12.1 0.4 0.43 11.0 0.4 1.6 1 0 0 1 1 1 0 Methyl-coenzyme M reductase alpha subunit, C-terminal domain SAM_1 PF00536.30 ETO23225.1 - 0.00035 20.9 0.1 0.00057 20.3 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RhoGAP PF00620.27 ETO23227.1 - 0.00011 22.0 0.0 0.00022 21.1 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain DUF452 PF04301.13 ETO23228.1 - 0.0014 18.2 0.0 0.002 17.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF452) zf-RanBP PF00641.18 ETO23229.1 - 0.00041 19.6 0.6 0.0014 17.9 0.6 1.9 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Pneumovirus_M2 PF06436.11 ETO23229.1 - 0.025 14.1 3.3 0.048 13.2 0.2 2.5 3 0 0 3 3 3 0 Pneumovirus matrix protein 2 (M2) Ras PF00071.22 ETO23230.1 - 7.7e-18 64.6 0.1 2.7e-10 40.1 0.0 2.4 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO23230.1 - 3.5e-08 33.7 0.0 8e-08 32.5 0.0 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Atrophin-1 PF03154.15 ETO23232.1 - 0.057 11.7 3.5 0.065 11.5 3.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family Polysacc_deac_1 PF01522.21 ETO23233.1 - 1.6 8.7 5.7 0.52 10.2 0.1 2.2 2 0 0 2 2 2 0 Polysaccharide deacetylase LAP1C PF05609.12 ETO23234.1 - 0.013 14.6 9.9 0.015 14.4 9.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 ETO23234.1 - 0.063 13.3 5.9 0.085 12.9 5.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Lin-8 PF03353.15 ETO23234.1 - 0.2 11.2 14.2 0.22 11.0 14.2 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist LMBR1 PF04791.16 ETO23234.1 - 0.28 10.1 7.3 0.35 9.7 7.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein GAGA_bind PF06217.12 ETO23234.1 - 0.55 10.5 14.3 0.69 10.2 14.3 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family Hid1 PF12722.7 ETO23234.1 - 1 7.4 17.2 1.2 7.2 17.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HGTP_anticodon2 PF12745.7 ETO23234.1 - 1.1 8.7 15.6 1.5 8.3 15.6 1.3 1 0 0 1 1 1 0 Anticodon binding domain of tRNAs CDC45 PF02724.14 ETO23234.1 - 1.5 7.0 15.5 2 6.6 15.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Menin PF05053.13 ETO23234.1 - 1.5 7.1 15.3 1.8 6.8 15.3 1.0 1 0 0 1 1 1 0 Menin SLC12 PF03522.15 ETO23234.1 - 2.1 7.3 15.8 2.8 6.9 15.8 1.2 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 ETO23234.1 - 5.2 4.1 15.8 5.8 3.9 15.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Fcf2 PF08698.11 ETO23237.1 - 0.066 13.6 1.3 0.1 13.0 0.3 1.8 2 0 0 2 2 2 0 Fcf2 pre-rRNA processing GWT1 PF06423.12 ETO23238.1 - 0.003 17.7 1.1 0.02 15.0 0.1 2.6 2 0 0 2 2 2 1 GWT1 DUF454 PF04304.13 ETO23238.1 - 0.1 12.6 0.1 0.27 11.3 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF454) DEAD PF00270.29 ETO23240.1 - 2.3e-41 141.5 0.4 1.7e-40 138.7 0.4 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO23240.1 - 1.2e-06 28.6 0.0 2.6e-06 27.6 0.0 1.6 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETO23240.1 - 1.1e-05 25.3 0.0 1.7e-05 24.6 0.0 1.2 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 ETO23240.1 - 4.5e-05 23.0 0.1 6.9e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 PhoH-like protein CMS1 PF14617.6 ETO23240.1 - 0.0008 18.8 0.0 0.0016 17.8 0.0 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit AAA_19 PF13245.6 ETO23240.1 - 0.00092 19.6 1.1 0.0021 18.4 0.1 1.9 2 1 0 2 2 2 1 AAA domain Helicase_RecD PF05127.14 ETO23240.1 - 0.0016 18.4 0.0 0.0026 17.6 0.0 1.3 1 0 0 1 1 1 1 Helicase SWI2_SNF2 PF18766.1 ETO23240.1 - 0.017 14.8 0.0 0.027 14.1 0.0 1.4 1 0 0 1 1 1 0 SWI2/SNF2 ATPase AAA_22 PF13401.6 ETO23240.1 - 0.028 14.7 0.0 0.075 13.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain Flavi_DEAD PF07652.14 ETO23240.1 - 0.1 12.5 0.1 0.21 11.6 0.1 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain ARS2 PF04959.13 ETO23241.1 - 1.1e-10 42.2 0.4 1.1e-10 42.2 0.4 1.9 2 0 0 2 2 2 1 Arsenite-resistance protein 2 DUF4187 PF13821.6 ETO23241.1 - 1.5e-06 27.9 1.6 3.6e-06 26.7 1.6 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4187) RRM_1 PF00076.22 ETO23241.1 - 0.023 14.5 0.0 0.048 13.5 0.0 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) YfhO PF09586.10 ETO23241.1 - 0.062 11.5 0.3 0.12 10.6 0.3 1.4 1 0 0 1 1 1 0 Bacterial membrane protein YfhO zf-C2H2_4 PF13894.6 ETO23241.1 - 0.46 11.5 7.3 1.7 9.7 1.9 3.3 2 0 0 2 2 2 0 C2H2-type zinc finger DUF3546 PF12066.8 ETO23242.1 - 0.00011 22.3 3.5 0.00011 22.3 3.5 2.4 2 1 0 2 2 2 1 Domain of unknown function (DUF3546) TMEM252 PF15664.5 ETO23242.1 - 0.0026 17.5 0.1 0.0055 16.4 0.1 1.6 1 0 0 1 1 1 1 Transmembrane protein 252 family RSRP PF17069.5 ETO23242.1 - 0.057 13.0 49.4 0.087 12.4 49.4 1.2 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 Exo_endo_phos PF03372.23 ETO23243.1 - 0.0015 18.1 0.0 0.0016 18.0 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family USP8_dimer PF08969.11 ETO23245.1 - 0.047 13.9 0.1 0.11 12.7 0.1 1.6 1 0 0 1 1 1 0 USP8 dimerisation domain Epimerase PF01370.21 ETO23246.1 - 6.1e-24 84.8 0.1 2.6e-23 82.7 0.1 1.8 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO23246.1 - 5.7e-19 68.2 0.0 7.2e-19 67.8 0.0 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETO23246.1 - 1.4e-13 51.1 0.0 2.2e-13 50.5 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding NAD_binding_4 PF07993.12 ETO23246.1 - 4.9e-12 45.6 0.3 8e-11 41.6 0.3 2.0 1 1 0 1 1 1 1 Male sterility protein GDP_Man_Dehyd PF16363.5 ETO23246.1 - 8.3e-11 41.8 0.0 2e-10 40.6 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ETO23246.1 - 2.4e-09 37.1 0.0 1.6e-08 34.4 0.0 2.0 2 0 0 2 2 2 1 NmrA-like family KR PF08659.10 ETO23246.1 - 4.9e-09 36.3 0.0 8.7e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO23246.1 - 9.1e-05 21.7 0.0 0.00015 21.0 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short PF00106.25 ETO23246.1 - 0.00049 19.6 0.1 0.0034 16.9 0.0 2.1 2 0 0 2 2 2 1 short chain dehydrogenase DUF2016 PF09436.10 ETO23246.1 - 0.11 12.3 0.0 0.24 11.2 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2016) Nt_Gln_amidase PF09764.9 ETO23247.1 - 3.8e-38 130.9 0.0 4.5e-38 130.7 0.0 1.0 1 0 0 1 1 1 1 N-terminal glutamine amidase G-alpha PF00503.20 ETO23248.1 - 0.00079 18.7 2.4 0.0049 16.1 2.4 2.1 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO23248.1 - 0.0015 18.0 0.0 0.0028 17.2 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family NOG1 PF06858.14 ETO23248.1 - 0.12 12.2 0.1 0.27 11.1 0.1 1.7 1 0 0 1 1 1 0 Nucleolar GTP-binding protein 1 (NOG1) SF-assemblin PF06705.11 ETO23249.1 - 0.0012 18.2 43.2 0.003 16.9 21.9 2.2 1 1 1 2 2 2 1 SF-assemblin/beta giardin LRRFIP PF09738.9 ETO23249.1 - 0.0087 15.6 39.3 0.14 11.6 22.7 2.4 2 0 0 2 2 2 2 LRRFIP family TMF_TATA_bd PF12325.8 ETO23249.1 - 0.017 15.4 14.0 0.017 15.4 14.0 4.4 2 2 3 5 5 5 0 TATA element modulatory factor 1 TATA binding Golgin_A5 PF09787.9 ETO23249.1 - 0.18 11.2 54.2 0.58 9.6 17.5 3.5 1 1 2 3 3 3 0 Golgin subfamily A member 5 Pox_A_type_inc PF04508.12 ETO23249.1 - 0.35 10.8 9.2 0.97 9.4 0.1 4.7 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat Spc7 PF08317.11 ETO23249.1 - 1.3 7.9 50.1 0.41 9.5 19.6 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein Baculo_PEP_C PF04513.12 ETO23249.1 - 1.6 8.7 10.3 2.5 8.1 0.9 3.2 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 ETO23249.1 - 2.8 5.3 48.2 16 2.9 13.3 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF3584) ApoO PF09769.9 ETO23249.1 - 3.4 7.6 12.8 1.5 8.8 0.6 4.4 1 1 3 4 4 4 0 Apolipoprotein O CENP-H PF05837.12 ETO23249.1 - 6.4 7.2 44.0 0.61 10.5 11.1 3.7 3 1 0 3 3 3 0 Centromere protein H (CENP-H) ATG22 PF11700.8 ETO23250.1 - 4.4e-30 104.7 8.4 1.4e-21 76.7 8.1 2.1 2 0 0 2 2 2 2 Vacuole effluxer Atg22 like Jacalin PF01419.17 ETO23250.1 - 0.0026 17.7 0.2 0.0092 15.9 0.0 1.9 2 0 0 2 2 2 1 Jacalin-like lectin domain S_4TM PF18159.1 ETO23250.1 - 0.045 13.1 0.2 0.13 11.6 0.2 1.7 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain DUF3021 PF11457.8 ETO23250.1 - 3 8.2 16.6 0.069 13.5 9.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3021) ATG22 PF11700.8 ETO23251.1 - 9.8e-05 21.2 0.0 0.0001 21.1 0.0 1.0 1 0 0 1 1 1 1 Vacuole effluxer Atg22 like INSIG PF07281.12 ETO23251.1 - 0.057 13.1 0.0 0.06 13.0 0.0 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) DUF1700 PF08006.11 ETO23252.1 - 0.2 11.1 13.1 0.28 10.7 13.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1700) Phage_holin_3_6 PF07332.11 ETO23252.1 - 1.4 9.0 17.4 2.3 8.3 17.4 1.3 1 0 0 1 1 1 0 Putative Actinobacterial Holin-X, holin superfamily III Tetraspanin PF00335.20 ETO23252.1 - 3.3 7.3 11.6 0.15 11.7 4.7 1.9 1 1 1 2 2 2 0 Tetraspanin family Phlebovirus_G1 PF07243.11 ETO23252.1 - 3.4 5.9 10.3 6.3 5.0 10.3 1.3 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 DUF2614 PF11023.8 ETO23252.1 - 5.8 7.1 10.0 9.8 6.3 10.0 1.4 1 0 0 1 1 1 0 Zinc-ribbon containing domain SDA1 PF05285.12 ETO23252.1 - 7.5 5.9 10.8 9.5 5.5 10.8 1.1 1 0 0 1 1 1 0 SDA1 Helicase_C PF00271.31 ETO23254.1 - 1.5e-18 67.2 0.0 3.2e-18 66.1 0.0 1.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO23254.1 - 7.5e-06 25.8 0.0 8.3e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase MF_alpha_N PF05436.11 ETO23254.1 - 0.075 12.9 0.2 7.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Mating factor alpha precursor N-terminus Coilin_N PF15862.5 ETO23256.1 - 0.00011 22.0 0.3 0.00011 22.0 0.3 2.2 2 0 0 2 2 2 1 Coilin N-terminus V_ATPase_I PF01496.19 ETO23256.1 - 0.002 16.2 0.5 0.0033 15.4 0.5 1.3 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family Zip PF02535.22 ETO23256.1 - 0.0021 17.3 0.4 0.0035 16.6 0.0 1.5 2 0 0 2 2 2 1 ZIP Zinc transporter Connexin PF00029.19 ETO23256.1 - 0.022 14.5 1.3 0.022 14.5 1.3 2.1 2 1 0 2 2 1 0 Connexin O-antigen_lig PF13425.6 ETO23256.1 - 0.14 10.9 3.7 0.043 12.6 0.4 1.8 2 0 0 2 2 2 0 O-antigen ligase like membrane protein RNA_pol_3_Rpc31 PF11705.8 ETO23256.1 - 0.14 12.3 18.4 0.24 11.6 18.4 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TRAP_alpha PF03896.16 ETO23256.1 - 0.25 10.5 6.5 0.47 9.6 6.5 1.4 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit MAP17 PF15807.5 ETO23256.1 - 0.59 10.4 13.1 0.043 14.0 6.2 2.2 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Vfa1 PF08432.10 ETO23256.1 - 0.75 10.1 20.1 0.34 11.2 16.5 1.9 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 ETO23256.1 - 1.2 9.5 9.7 0.22 11.9 5.5 1.8 2 0 0 2 2 2 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 ETO23256.1 - 2.5 8.3 13.0 9.2 6.4 12.7 1.9 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ANAPC15 PF15243.6 ETO23256.1 - 2.5 8.5 26.1 0.19 12.1 20.5 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 Peptidase_S49_N PF08496.10 ETO23256.1 - 3.3 7.7 9.8 0.11 12.5 3.8 1.6 2 0 0 2 2 1 0 Peptidase family S49 N-terminal NARP1 PF12569.8 ETO23256.1 - 3.7 6.3 18.3 5.8 5.7 18.3 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DUF4746 PF15928.5 ETO23256.1 - 4.1 6.8 18.1 6.6 6.1 18.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF913 PF06025.12 ETO23256.1 - 4.6 6.1 8.5 8.6 5.2 8.5 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Afi1 PF07792.12 ETO23256.1 - 5 7.6 15.3 11 6.5 12.3 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4820 PF16091.5 ETO23256.1 - 5.4 6.3 14.4 1.2 8.4 10.9 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) FAM176 PF14851.6 ETO23256.1 - 8.8 6.0 17.1 2.7 7.7 13.9 1.7 2 0 0 2 2 2 0 FAM176 family MAP17 PF15807.5 ETO23257.1 - 0.0023 18.2 0.4 0.94 9.7 0.1 2.4 2 0 0 2 2 2 2 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4692 PF15763.5 ETO23257.1 - 0.03 14.8 0.5 0.15 12.6 0.0 2.2 2 1 1 3 3 3 0 Regulator of human erythroid cell expansion (RHEX) Herpes_LMP1 PF05297.11 ETO23257.1 - 0.042 13.0 0.0 0.042 13.0 0.0 2.5 3 0 0 3 3 3 0 Herpesvirus latent membrane protein 1 (LMP1) G0-G1_switch_2 PF15103.6 ETO23257.1 - 0.12 12.8 0.4 0.35 11.3 0.0 1.9 2 0 0 2 2 2 0 G0/G1 switch protein 2 DUF4381 PF14316.6 ETO23257.1 - 0.75 10.0 0.0 0.75 10.0 0.0 2.7 3 1 0 3 3 3 0 Domain of unknown function (DUF4381) UL42 PF17638.2 ETO23257.1 - 8 6.5 6.8 19 5.2 0.1 3.1 3 0 0 3 3 3 0 HCMV UL42 WD40 PF00400.32 ETO23258.1 - 7.2e-06 26.6 3.1 9e-06 26.3 1.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat zf-RanBP PF00641.18 ETO23260.1 - 0.00024 20.3 15.7 0.039 13.3 0.4 2.5 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others zf-Sec23_Sec24 PF04810.15 ETO23260.1 - 0.033 14.2 0.4 0.033 14.2 0.4 3.4 2 2 2 4 4 4 0 Sec23/Sec24 zinc finger eIF-3_zeta PF05091.12 ETO23261.1 - 0.019 14.0 27.5 0.04 12.9 27.5 1.6 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) PAT1 PF09770.9 ETO23261.1 - 0.025 12.9 56.6 0.04 12.2 56.6 1.3 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SID-1_RNA_chan PF13965.6 ETO23261.1 - 0.98 7.7 12.3 1.7 6.9 12.3 1.4 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 zinc_ribbon_2 PF13240.6 ETO23261.1 - 1.2 8.9 4.1 0.84 9.4 0.8 2.6 2 0 0 2 2 2 0 zinc-ribbon domain DUF4964 PF16334.5 ETO23261.1 - 2.1 7.9 0.0 2.1 7.9 0.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4964) Pex16 PF08610.10 ETO23261.1 - 8.9 5.4 15.9 22 4.1 15.9 1.6 1 0 0 1 1 1 0 Peroxisomal membrane protein (Pex16) DUF4175 PF13779.6 ETO23261.1 - 9.1 4.1 62.1 15 3.3 62.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) VWA PF00092.28 ETO23262.1 - 1.5e-07 31.8 0.1 1.4e-05 25.4 0.1 2.3 1 1 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO23262.1 - 0.00016 22.3 0.1 0.00084 20.0 0.0 2.1 2 1 0 2 2 2 1 von Willebrand factor type A domain Type_ISP_C PF18135.1 ETO23262.1 - 0.13 11.3 0.0 0.18 10.7 0.0 1.2 1 0 0 1 1 1 0 Type ISP C-terminal specificity domain Smg8_Smg9 PF10220.9 ETO23264.1 - 2.5e-53 181.7 29.1 4.7e-33 114.6 14.6 4.2 3 1 1 4 4 4 3 Smg8_Smg9 DDHD PF02862.17 ETO23264.1 - 0.04 14.1 3.1 1.5 8.9 0.3 3.1 3 0 0 3 3 3 0 DDHD domain GBP_C PF02841.14 ETO23264.1 - 0.042 13.3 8.1 0.28 10.6 0.0 2.5 2 0 0 2 2 2 0 Guanylate-binding protein, C-terminal domain DUF3449 PF11931.8 ETO23264.1 - 1.7 8.4 8.7 26 4.5 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3449) Vfa1 PF08432.10 ETO23264.1 - 4.5 7.6 22.6 0.025 14.9 7.6 3.1 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 DUF2828 PF11443.8 ETO23264.1 - 6.3 4.8 11.5 0.039 12.1 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF2828) SID-1_RNA_chan PF13965.6 ETO23266.1 - 0.0004 18.9 10.5 0.0004 18.9 10.5 2.2 3 0 0 3 3 3 1 dsRNA-gated channel SID-1 Baculo_11_kDa PF06143.11 ETO23266.1 - 0.019 14.5 4.0 2 8.1 1.3 2.9 2 0 0 2 2 2 0 Baculovirus 11 kDa family Neur_chan_memb PF02932.16 ETO23266.1 - 0.09 12.8 6.2 0.19 11.7 6.2 1.6 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cation_ATPase_C PF00689.21 ETO23266.1 - 3.5 7.3 12.3 4.9 6.8 8.5 2.7 3 0 0 3 3 3 0 Cation transporting ATPase, C-terminus PT PF04886.12 ETO23267.1 - 5.6 6.6 15.3 11 5.7 15.3 1.4 1 0 0 1 1 1 0 PT repeat Zip PF02535.22 ETO23268.1 - 0.019 14.2 3.9 0.031 13.5 0.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter TRAM_LAG1_CLN8 PF03798.16 ETO23269.1 - 5.9e-12 45.7 20.2 1.3e-11 44.6 20.2 1.6 1 1 0 1 1 1 1 TLC domain HlyIII PF03006.20 ETO23271.1 - 9.4e-23 81.1 12.3 9.4e-23 81.1 12.3 1.5 2 0 0 2 2 2 1 Haemolysin-III related DUF4834 PF16118.5 ETO23271.1 - 0.013 16.5 0.1 0.013 16.5 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Pox_Ag35 PF03286.14 ETO23271.1 - 0.12 12.2 2.0 0.17 11.7 2.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FixH PF05751.11 ETO23271.1 - 0.38 10.8 2.9 0.71 9.9 0.0 2.5 3 0 0 3 3 3 0 FixH PetM PF08041.11 ETO23271.1 - 1.4 8.6 8.0 1.5 8.5 0.6 2.8 2 0 0 2 2 2 0 PetM family of cytochrome b6f complex subunit 7 E1-E2_ATPase PF00122.20 ETO23272.1 - 4.9e-21 75.0 1.3 2e-19 69.8 0.1 2.1 2 0 0 2 2 2 2 E1-E2 ATPase Cation_ATPase_N PF00690.26 ETO23272.1 - 7e-13 48.1 6.0 3.3e-07 29.9 0.5 2.9 3 0 0 3 3 3 2 Cation transporter/ATPase, N-terminus BacA PF02673.18 ETO23272.1 - 0.043 13.5 0.1 0.059 13.1 0.1 1.1 1 0 0 1 1 1 0 Bacitracin resistance protein BacA NicO PF03824.16 ETO23272.1 - 0.15 11.4 0.1 0.19 11.1 0.1 1.1 1 0 0 1 1 1 0 High-affinity nickel-transport protein HupF_HypC PF01455.18 ETO23272.1 - 0.32 11.2 1.4 1.6 9.0 0.2 2.7 3 1 1 4 4 4 0 HupF/HypC family Prok-RING_4 PF14447.6 ETO23273.1 - 5.9e-05 22.9 6.8 0.00016 21.5 6.8 1.7 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO23273.1 - 6.6e-05 23.2 8.3 6.6e-05 23.2 8.3 2.2 2 0 0 2 2 2 1 Ring finger domain zf-RING_UBOX PF13445.6 ETO23273.1 - 0.00021 21.3 5.8 0.00021 21.3 5.8 2.8 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO23273.1 - 0.00071 19.4 10.7 0.00071 19.4 10.7 2.3 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO23273.1 - 0.0008 19.3 10.2 0.0029 17.5 10.1 2.1 1 1 0 1 1 1 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETO23273.1 - 0.0019 18.3 9.2 0.0019 18.3 9.2 2.0 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING Transcrip_reg PF01709.20 ETO23273.1 - 0.013 15.0 2.2 0.013 15.0 2.2 2.0 3 0 0 3 3 3 0 Transcriptional regulator zf-C3HC4_2 PF13923.6 ETO23273.1 - 0.02 14.7 12.1 0.093 12.6 10.7 2.6 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO23273.1 - 0.036 14.4 6.9 0.14 12.5 6.9 2.1 1 0 0 1 1 1 0 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ETO23273.1 - 5 7.0 16.1 0.11 12.4 7.9 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain DUF4858 PF16150.5 ETO23275.1 - 0.16 12.0 0.0 0.54 10.3 0.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4858) FA_desaturase PF00487.24 ETO23276.1 - 2.9e-06 27.3 7.3 2.9e-06 27.3 7.3 1.9 1 1 1 2 2 2 1 Fatty acid desaturase Glyco_H_20C_C PF18088.1 ETO23276.1 - 0.057 13.3 0.1 0.057 13.3 0.1 1.5 2 0 0 2 2 2 0 Glycoside Hydrolase 20C C-terminal domain zf-3CxxC_2 PF17180.4 ETO23276.1 - 0.52 11.1 3.6 1.3 9.8 3.6 1.7 1 0 0 1 1 1 0 Zinc-binding domain Anticodon_1 PF08264.13 ETO23277.1 - 9.6e-28 97.1 0.0 9.9e-27 93.8 0.0 2.3 2 0 0 2 2 2 1 Anticodon-binding domain of tRNA CS PF04969.16 ETO23278.1 - 0.0026 18.7 0.9 0.01 16.8 0.9 2.0 1 0 0 1 1 1 1 CS domain Trypan_glycop PF00913.19 ETO23278.1 - 0.0081 15.5 0.9 0.0081 15.5 0.9 1.9 2 0 0 2 2 2 1 Trypanosome variant surface glycoprotein (A-type) Pih1_fungal_CS PF18482.1 ETO23278.1 - 0.038 14.5 3.5 0.048 14.2 2.0 2.0 1 1 0 1 1 1 0 Fungal Pih1 CS domain Fer4_14 PF13394.6 ETO23278.1 - 0.056 13.6 0.9 0.19 11.8 0.8 2.0 1 1 0 1 1 1 0 4Fe-4S single cluster domain CPT_N PF16484.5 ETO23278.1 - 0.19 11.8 0.1 0.41 10.7 0.1 1.6 1 0 0 1 1 1 0 Carnitine O-palmitoyltransferase N-terminus Rhodanese PF00581.20 ETO23279.1 - 1.2e-21 77.2 0.3 7.7e-11 42.5 0.2 3.3 2 1 0 2 2 2 2 Rhodanese-like domain TFIIA PF03153.13 ETO23281.1 - 0.004 17.2 8.9 0.0044 17.1 8.9 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF5466 PF17554.2 ETO23282.1 - 0.049 13.8 0.0 0.12 12.6 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5466) WD40 PF00400.32 ETO23283.1 - 1.2e-07 32.3 1.8 0.13 13.2 0.0 3.8 4 0 0 4 4 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23283.1 - 0.0032 17.7 0.0 0.87 9.9 0.0 3.2 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CRIC_ras_sig PF10534.9 ETO23283.1 - 0.007 16.5 1.4 0.016 15.3 0.2 2.0 1 1 0 2 2 2 1 Connector enhancer of kinase suppressor of ras Sas10_Utp3 PF04000.15 ETO23283.1 - 0.11 13.2 5.9 0.37 11.5 2.3 2.6 2 0 0 2 2 2 0 Sas10/Utp3/C1D family Tropomyosin_1 PF12718.7 ETO23283.1 - 0.29 11.3 23.9 0.54 10.4 1.7 2.3 2 0 0 2 2 2 0 Tropomyosin like SKA2 PF16740.5 ETO23283.1 - 0.37 10.6 11.8 0.029 14.1 4.0 2.4 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 DUF3886 PF13025.6 ETO23283.1 - 0.7 10.1 16.0 0.047 13.9 9.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3886) DUF4665 PF15679.5 ETO23283.1 - 0.91 10.2 12.1 0.21 12.2 5.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) LPP PF04728.13 ETO23283.1 - 0.91 10.0 4.9 18 5.8 0.2 2.6 2 0 0 2 2 2 0 Lipoprotein leucine-zipper FlxA PF14282.6 ETO23283.1 - 1.5 8.8 16.7 0.41 10.7 7.8 2.3 2 0 0 2 2 2 0 FlxA-like protein Spc24 PF08286.11 ETO23283.1 - 1.7 8.9 13.5 2.9 8.2 6.6 2.5 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF5320 PF17253.2 ETO23283.1 - 1.8 9.7 8.1 5.9 8.0 0.0 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5320) Helo_like_N PF17111.5 ETO23283.1 - 2 7.7 13.6 0.14 11.5 5.9 2.3 2 1 0 2 2 2 0 Fungal N-terminal domain of STAND proteins DUF3090 PF11290.8 ETO23283.1 - 5.1 6.9 5.6 1.3 8.8 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3090) Phage_Gp23 PF10669.9 ETO23283.1 - 5.1 7.4 10.7 0.58 10.5 5.7 2.0 2 1 1 3 3 3 0 Protein gp23 (Bacteriophage A118) 60KD_IMP PF02096.20 ETO23283.1 - 5.4 6.9 6.4 1.8 8.4 2.1 2.1 2 0 0 2 2 2 0 60Kd inner membrane protein DUF2203 PF09969.9 ETO23283.1 - 6 7.6 12.0 4.9 7.9 5.5 2.7 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2203) HALZ PF02183.18 ETO23284.1 - 3.7e-08 33.4 111.3 0.0012 19.0 3.4 16.0 13 4 3 16 16 16 10 Homeobox associated leucine zipper Spc7 PF08317.11 ETO23284.1 - 0.0015 17.5 23.0 0.0015 17.5 23.0 7.2 1 1 8 9 9 9 6 Spc7 kinetochore protein V-SNARE PF05008.15 ETO23284.1 - 0.0082 16.5 12.1 0.0082 16.5 12.1 8.5 8 4 1 10 10 10 2 Vesicle transport v-SNARE protein N-terminus OAD_gamma PF04277.13 ETO23284.1 - 1.8 9.2 0.0 1.8 9.2 0.0 3.2 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain PhoLip_ATPase_N PF16209.5 ETO23285.1 - 1.4e-24 85.6 1.5 2.1e-24 85.0 1.5 1.3 1 0 0 1 1 1 1 Phospholipid-translocating ATPase N-terminal Mlo PF03094.15 ETO23285.1 - 0.11 10.8 1.5 0.15 10.5 1.5 1.1 1 0 0 1 1 1 0 Mlo family TPR_12 PF13424.6 ETO23286.1 - 9e-21 74.0 2.3 4.8e-14 52.4 0.1 3.0 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23286.1 - 1.9e-10 40.1 4.3 0.00089 19.0 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO23286.1 - 3.6e-10 39.4 1.0 0.00022 21.0 0.0 4.3 5 0 0 5 5 5 2 Tetratricopeptide repeat Kelch_6 PF13964.6 ETO23286.1 - 8.5e-10 38.6 0.4 0.0048 17.1 0.0 3.6 2 1 1 3 3 3 2 Kelch motif TPR_2 PF07719.17 ETO23286.1 - 7.1e-09 35.1 3.6 0.01 15.9 0.0 3.7 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23286.1 - 4.2e-08 32.8 6.3 0.00016 21.6 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23286.1 - 9.8e-08 31.5 1.9 0.0057 16.6 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat Kelch_1 PF01344.25 ETO23286.1 - 1.5e-06 27.7 0.2 0.0052 16.3 0.0 3.0 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO23286.1 - 0.0015 18.5 0.0 0.11 12.5 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO23286.1 - 0.0029 17.5 0.3 3 8.0 0.1 3.1 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO23286.1 - 0.015 15.3 1.2 9.9 6.3 0.0 4.3 4 0 0 4 4 4 0 Kelch motif TPR_6 PF13174.6 ETO23286.1 - 0.15 12.8 0.2 70 4.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO23287.1 - 4.1e-60 198.3 26.7 5.6e-13 49.2 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23287.1 - 4.8e-19 68.4 6.9 0.00093 19.4 0.1 5.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO23287.1 - 1.6e-13 50.7 2.9 0.0008 18.8 0.1 3.2 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO23287.1 - 1e-08 34.6 1.7 0.015 14.3 0.0 4.9 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO23287.1 - 6.7e-08 31.6 8.5 0.19 10.3 0.0 5.0 2 1 3 5 5 5 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO23287.1 - 7.4e-08 32.5 0.4 0.0065 16.4 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Me-amine-dh_H PF06433.11 ETO23287.1 - 1.9e-05 23.7 0.0 0.48 9.2 0.0 3.6 2 1 2 4 4 4 2 Methylamine dehydrogenase heavy chain (MADH) Cytochrom_D1 PF02239.16 ETO23287.1 - 2e-05 23.3 0.6 0.013 14.0 0.0 2.6 1 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5046 PF16465.5 ETO23287.1 - 9.9e-05 21.9 0.1 0.091 12.2 0.0 2.8 1 1 2 3 3 3 2 Domain of unknown function (DUF5046) PD40 PF07676.12 ETO23287.1 - 0.013 15.4 0.1 6 6.9 0.0 2.8 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat CppA_C PF14507.6 ETO23287.1 - 0.033 14.9 1.9 0.51 11.1 0.0 2.6 3 0 0 3 3 3 0 CppA C-terminal Coatomer_WDAD PF04053.14 ETO23287.1 - 0.042 12.9 2.4 13 4.6 1.0 2.9 1 1 2 3 3 3 0 Coatomer WD associated region Resistin PF06954.11 ETO23287.1 - 0.095 13.3 7.7 21 5.7 0.1 4.8 2 2 2 5 5 5 0 Resistin VID27 PF08553.10 ETO23287.1 - 0.11 11.6 0.2 1.3 8.0 0.0 2.5 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain Nucleoporin_N PF08801.11 ETO23287.1 - 0.58 8.8 8.5 3 6.5 0.5 4.3 1 1 2 3 3 3 0 Nup133 N terminal like WD40 PF00400.32 ETO23288.1 - 6.9e-65 213.4 22.1 1.5e-10 41.4 0.1 7.4 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23288.1 - 1.2e-23 83.2 0.3 0.0053 17.0 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23288.1 - 1.6e-12 47.1 0.2 0.047 12.6 0.0 6.3 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO23288.1 - 2.1e-10 40.8 0.2 4.6e-07 29.9 0.1 3.1 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO23288.1 - 7e-10 38.7 0.6 0.00043 19.7 0.1 3.9 3 2 0 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO23288.1 - 4.9e-09 35.4 1.4 0.28 9.8 0.0 5.1 1 1 6 7 7 7 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO23288.1 - 1.5e-07 31.2 4.6 4.7 7.3 0.0 6.7 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO23288.1 - 2.3e-06 27.7 0.0 1.6 8.8 0.0 4.9 2 1 3 5 5 5 1 Family of unknown function (DUF5570) PALB2_WD40 PF16756.5 ETO23288.1 - 5.7e-05 22.2 1.1 3.4 6.5 0.0 4.4 3 2 1 5 5 5 2 Partner and localizer of BRCA2 WD40 domain Str_synth PF03088.16 ETO23288.1 - 0.0032 17.6 0.0 5 7.3 0.0 3.9 4 1 0 4 4 4 1 Strictosidine synthase SBD PF17882.1 ETO23288.1 - 0.0035 17.2 0.3 9 6.1 0.0 4.1 2 2 3 5 5 5 1 OAA-family lectin sugar binding domain PQQ PF01011.21 ETO23288.1 - 0.0041 17.0 0.0 0.43 10.6 0.0 3.4 3 0 0 3 3 3 1 PQQ enzyme repeat Nbas_N PF15492.6 ETO23288.1 - 0.02 14.2 0.8 8.8 5.6 0.1 3.2 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO23288.1 - 0.021 13.3 0.0 0.43 9.0 0.0 2.7 1 1 1 2 2 2 0 Cytochrome D1 heme domain EcoRI PF02963.16 ETO23288.1 - 0.092 11.7 0.2 6.2 5.7 0.0 3.1 2 1 0 3 3 3 0 Restriction endonuclease EcoRI AcetylCoA_hyd_C PF13336.6 ETO23288.1 - 0.11 12.4 0.0 6.1 6.8 0.0 2.3 2 0 0 2 2 2 0 Acetyl-CoA hydrolase/transferase C-terminal domain DUF4221 PF13970.6 ETO23288.1 - 0.18 11.3 1.7 35 3.8 1.1 3.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) DUF4999 PF16390.5 ETO23288.1 - 0.21 11.9 4.8 76 3.7 0.1 4.5 4 1 1 5 5 5 0 Domain of unknown function MIase PF02426.16 ETO23288.1 - 0.23 11.7 0.0 13 6.1 0.0 3.4 5 0 0 5 5 4 0 Muconolactone delta-isomerase Pkinase PF00069.25 ETO23289.1 - 1.3e-23 83.8 0.7 6.4e-19 68.3 0.1 2.6 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23289.1 - 3.9e-14 52.6 0.7 1.5e-13 50.7 0.0 2.1 2 1 1 3 3 3 1 Protein tyrosine kinase Kdo PF06293.14 ETO23289.1 - 2.2e-06 27.2 1.5 1e-05 25.0 1.5 2.0 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Utp14 PF04615.13 ETO23289.1 - 0.022 13.4 33.8 0.027 13.1 33.8 1.1 1 0 0 1 1 1 0 Utp14 protein APH PF01636.23 ETO23289.1 - 0.05 13.5 0.0 0.076 12.9 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Roughex PF06020.11 ETO23289.1 - 0.68 9.0 14.8 0.86 8.6 14.8 1.3 1 0 0 1 1 1 0 Drosophila roughex protein PI3K_1B_p101 PF10486.9 ETO23289.1 - 0.82 7.4 19.3 0.99 7.1 19.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LAP1C PF05609.12 ETO23289.1 - 3.3 6.7 27.8 4.2 6.4 27.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DNA_pol_phi PF04931.13 ETO23289.1 - 4 5.4 35.4 5.9 4.9 35.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi G-alpha PF00503.20 ETO23290.1 - 1.3e-51 175.9 10.1 1.8e-51 175.4 10.1 1.2 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO23290.1 - 1.5e-05 24.5 0.6 0.017 14.5 0.2 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family AAA_7 PF12775.7 ETO23290.1 - 0.00067 19.2 0.1 0.0013 18.3 0.1 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 ETO23290.1 - 0.0013 19.3 0.2 0.0037 17.8 0.0 1.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ETO23290.1 - 0.0027 17.8 0.0 0.035 14.2 0.0 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase Viral_helicase1 PF01443.18 ETO23290.1 - 0.0037 17.0 0.0 0.0065 16.2 0.0 1.4 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase FtsK_SpoIIIE PF01580.18 ETO23290.1 - 0.004 16.5 0.1 0.078 12.3 0.0 2.2 2 0 0 2 2 2 1 FtsK/SpoIIIE family ABC_tran PF00005.27 ETO23290.1 - 0.0067 16.9 0.3 0.015 15.8 0.3 1.7 1 1 0 1 1 1 1 ABC transporter ATP_bind_1 PF03029.17 ETO23290.1 - 0.0096 15.7 0.2 0.21 11.3 0.1 2.4 2 0 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 ETO23290.1 - 0.013 15.2 0.0 0.03 14.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ETO23290.1 - 0.014 15.5 0.4 0.29 11.3 0.1 2.6 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 ETO23290.1 - 0.037 14.1 0.0 0.11 12.6 0.0 1.8 1 0 0 1 1 1 0 Helicase HerA, central domain Ecm29 PF13001.7 ETO23290.1 - 0.047 12.4 0.3 0.19 10.3 0.1 1.9 2 0 0 2 2 2 0 Proteasome stabiliser Dynamin_N PF00350.23 ETO23290.1 - 0.048 13.7 0.1 0.13 12.3 0.0 1.7 2 0 0 2 2 2 0 Dynamin family RsgA_GTPase PF03193.16 ETO23290.1 - 0.051 13.5 0.0 0.28 11.1 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase Mg_chelatase PF01078.21 ETO23290.1 - 0.054 12.9 0.1 0.21 11.0 0.0 1.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Roc PF08477.13 ETO23290.1 - 0.055 13.7 0.2 0.43 10.8 0.1 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ETO23290.1 - 0.062 13.7 0.0 0.15 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain AAA_19 PF13245.6 ETO23290.1 - 0.073 13.4 1.1 1.1 9.6 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO23290.1 - 0.094 13.0 0.4 0.35 11.1 0.1 2.1 2 1 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ETO23290.1 - 0.12 12.6 0.1 0.29 11.4 0.1 1.6 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO23290.1 - 0.16 11.6 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain SR-25 PF10500.9 ETO23291.1 - 0.00071 19.3 4.7 0.0012 18.5 4.7 1.4 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CCD48 PF15799.5 ETO23291.1 - 0.005 15.2 0.3 0.0057 15.0 0.3 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 48 Macoilin PF09726.9 ETO23291.1 - 0.051 12.1 9.0 0.055 12.0 9.0 1.0 1 0 0 1 1 1 0 Macoilin family Period_C PF12114.8 ETO23291.1 - 0.052 13.1 7.6 0.086 12.4 7.6 1.4 1 0 0 1 1 1 0 Period protein 2/3C-terminal region MPM1 PF17234.2 ETO23291.1 - 0.073 13.3 2.7 0.14 12.4 2.7 1.6 1 0 0 1 1 1 0 Mitochondrial peculiar membrane protein 1 RXLR PF16810.5 ETO23291.1 - 1.2 9.6 9.1 0.26 11.7 3.8 2.3 2 1 0 2 2 2 0 RXLR phytopathogen effector protein, Avirulence activity Thiamine_BP PF01910.17 ETO23292.1 - 1.5e-28 98.5 0.0 2.1e-28 98.0 0.0 1.2 1 0 0 1 1 1 1 Thiamine-binding protein PH PF00169.29 ETO23294.1 - 1.9e-06 28.3 0.1 2.5e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 PH domain PH_9 PF15410.6 ETO23294.1 - 0.0015 18.9 0.0 0.0019 18.5 0.0 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 ETO23294.1 - 0.0068 16.7 0.1 0.0096 16.3 0.1 1.5 1 1 0 1 1 1 1 Plant pleckstrin homology-like region PH_16 PF17838.1 ETO23294.1 - 0.029 14.2 0.0 0.036 13.9 0.0 1.3 1 0 0 1 1 1 0 PH domain Nodulin_late PF07127.11 ETO23294.1 - 0.14 12.5 0.4 0.14 12.5 0.4 1.6 2 0 0 2 2 2 0 Late nodulin protein DSS1_SEM1 PF05160.13 ETO23295.1 - 5.1e-06 26.5 22.2 1.1e-05 25.4 22.1 1.6 1 1 0 1 1 1 1 DSS1/SEM1 family DUF4795 PF16043.5 ETO23296.1 - 0.0031 17.2 7.5 0.0045 16.6 7.5 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) HIP1_clath_bdg PF16515.5 ETO23296.1 - 0.0039 17.8 17.5 0.0087 16.7 3.1 3.0 3 0 0 3 3 3 2 Clathrin-binding domain of Huntingtin-interacting protein 1 Tektin PF03148.14 ETO23296.1 - 0.0045 15.8 2.8 0.0045 15.8 2.8 2.3 1 1 0 2 2 2 1 Tektin family DUF3584 PF12128.8 ETO23296.1 - 0.012 13.2 9.4 0.02 12.5 9.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) NPV_P10 PF05531.12 ETO23296.1 - 0.013 15.9 3.9 0.04 14.4 1.5 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 ETO23296.1 - 0.018 15.1 1.3 0.71 9.9 0.4 2.3 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CENP-Q PF13094.6 ETO23296.1 - 0.028 14.6 7.4 0.048 13.9 7.4 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit PTPLA PF04387.14 ETO23296.1 - 0.05 13.3 0.0 0.093 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase-like protein, PTPLA Peptidase_S46 PF10459.9 ETO23296.1 - 0.18 10.4 5.3 0.21 10.2 5.3 1.1 1 0 0 1 1 1 0 Peptidase S46 UPF0242 PF06785.11 ETO23296.1 - 0.19 11.8 15.4 0.37 10.9 14.6 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus PilJ PF13675.6 ETO23296.1 - 0.35 10.9 3.6 0.56 10.2 1.4 2.3 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Sec34 PF04136.15 ETO23296.1 - 0.45 10.4 15.9 0.086 12.7 6.9 2.6 2 1 1 3 3 3 0 Sec34-like family eIF-5_eIF-2B PF01873.17 ETO23296.1 - 0.6 10.0 4.0 0.34 10.8 1.0 2.2 2 2 0 2 2 2 0 Domain found in IF2B/IF5 DUF948 PF06103.11 ETO23296.1 - 0.65 10.3 5.9 23 5.4 1.0 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF745 PF05335.13 ETO23296.1 - 1.1 9.0 8.6 2.1 8.0 8.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) YscO-like PF16789.5 ETO23296.1 - 1.4 8.9 14.7 0.036 14.1 5.3 2.2 1 1 1 2 2 2 0 YscO-like protein RuvC_III PF18541.1 ETO23296.1 - 1.4 8.8 12.0 6 6.8 0.2 2.5 2 1 0 2 2 2 0 RuvC endonuclease subdomain 3 CENP-H PF05837.12 ETO23296.1 - 1.9 8.9 14.5 0.49 10.8 11.2 1.7 2 0 0 2 2 2 0 Centromere protein H (CENP-H) FapA PF03961.13 ETO23296.1 - 2.4 6.6 9.3 4.2 5.9 9.3 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A ZapD PF07072.11 ETO23296.1 - 2.9 7.6 10.9 0.27 11.0 4.0 2.5 1 1 1 2 2 2 0 Cell division protein Syntaxin-6_N PF09177.11 ETO23296.1 - 3 8.5 11.1 11 6.6 7.5 2.8 2 1 0 2 2 2 0 Syntaxin 6, N-terminal DUF4665 PF15679.5 ETO23296.1 - 6.5 7.4 16.7 0.13 12.9 4.5 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) FlaC_arch PF05377.11 ETO23296.1 - 8.6 6.8 9.2 1.5 9.3 1.0 3.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) ORC5_C PF14630.6 ETO23297.1 - 1.4e-35 123.2 8.5 1.6e-33 116.4 8.5 2.1 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 5 C-terminus AAA_16 PF13191.6 ETO23297.1 - 2.5e-09 37.7 0.0 1.5e-08 35.2 0.0 2.3 2 2 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ETO23297.1 - 0.0086 15.9 2.3 1.4 8.6 0.0 2.3 2 0 0 2 2 2 2 AAA domain AAA PF00004.29 ETO23297.1 - 0.0091 16.4 0.1 0.065 13.7 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) ATPase_2 PF01637.18 ETO23297.1 - 0.017 15.0 0.1 0.017 15.0 0.1 2.8 3 1 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_33 PF13671.6 ETO23297.1 - 0.022 14.9 0.0 0.066 13.4 0.0 1.8 1 0 0 1 1 1 0 AAA domain SPOB_ab PF14682.6 ETO23297.1 - 0.097 12.8 2.1 0.86 9.7 0.0 2.7 2 1 0 2 2 2 0 Sporulation initiation phospho-transferase B, C-terminal AAA_22 PF13401.6 ETO23297.1 - 0.13 12.5 1.6 0.72 10.1 0.2 3.0 2 1 0 2 2 2 0 AAA domain AAA_19 PF13245.6 ETO23297.1 - 0.14 12.5 0.0 0.51 10.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain SF3A3 PF16837.5 ETO23297.1 - 0.37 11.3 2.9 1.5 9.4 0.1 3.0 2 1 1 3 3 3 0 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 CENP-B_dimeris PF09026.10 ETO23299.1 - 0.026 14.9 4.9 0.026 14.9 4.9 2.6 2 1 0 2 2 2 0 Centromere protein B dimerisation domain Connexin PF00029.19 ETO23299.1 - 0.088 12.6 0.5 0.16 11.7 0.0 1.6 2 0 0 2 2 2 0 Connexin DUF3246 PF11596.8 ETO23299.1 - 0.19 11.1 11.0 0.3 10.5 4.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) Menin PF05053.13 ETO23299.1 - 2.8 6.2 8.0 3.8 5.8 8.0 1.2 1 0 0 1 1 1 0 Menin NOA36 PF06524.12 ETO23299.1 - 3 7.1 20.4 1.3 8.2 6.6 2.3 2 0 0 2 2 2 0 NOA36 protein DUF4834 PF16118.5 ETO23299.1 - 3.4 8.7 7.2 0.67 10.9 2.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) GH115_C PF17829.1 ETO23300.1 - 0.2 11.5 2.5 0.31 10.8 1.5 1.7 1 1 1 2 2 2 0 Gylcosyl hydrolase family 115 C-terminal domain Mucin PF01456.17 ETO23300.1 - 1.3 9.0 25.6 0.13 12.3 20.5 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein SSP160 PF06933.11 ETO23300.1 - 7.1 4.7 20.0 11 4.1 20.0 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF4704 PF15787.5 ETO23302.1 - 9.2e-06 25.1 0.6 0.07 12.4 1.3 3.2 2 1 0 2 2 2 2 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 ETO23302.1 - 0.00013 22.2 0.0 0.00029 21.0 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily tRNA-synt_1 PF00133.22 ETO23305.1 - 3.4e-09 35.5 0.2 1.5e-08 33.4 0.2 1.8 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETO23305.1 - 1e-07 31.1 0.3 1.3e-06 27.5 0.3 2.2 1 1 0 1 1 1 1 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ETO23305.1 - 1.4e-07 31.1 0.0 2.9e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF2497 PF10691.9 ETO23306.1 - 1.1e-10 41.8 0.9 1.1e-10 41.8 0.9 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2497) RasGAP PF00616.19 ETO23308.1 - 9.5e-10 38.5 3.4 9.5e-10 38.5 3.4 2.3 2 0 0 2 2 2 1 GTPase-activator protein for Ras-like GTPase Paf1 PF03985.13 ETO23308.1 - 0.0022 17.1 16.4 0.0022 17.1 16.4 1.5 2 0 0 2 2 2 1 Paf1 DUF2052 PF09747.9 ETO23308.1 - 0.91 9.6 26.6 0.68 10.0 22.4 2.2 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Nop14 PF04147.12 ETO23308.1 - 0.95 7.6 38.3 0.32 9.2 32.6 2.1 2 0 0 2 2 2 0 Nop14-like family Pox_Ag35 PF03286.14 ETO23308.1 - 2.1 8.1 29.1 3.3 7.5 19.1 3.3 3 0 0 3 3 3 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ETO23308.1 - 5.5 5.2 28.3 10 4.3 28.3 1.4 1 0 0 1 1 1 0 CDC45-like protein Rhabdo_ncap PF00945.18 ETO23308.1 - 7.1 5.4 9.8 11 4.8 9.8 1.4 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein CobT PF06213.12 ETO23308.1 - 7.5 5.9 26.0 13 5.1 26.0 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Astro_capsid_p PF12226.8 ETO23308.1 - 7.9 5.5 22.1 0.63 9.1 17.3 1.5 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Anoctamin PF04547.12 ETO23309.1 - 4e-49 167.7 11.3 4.9e-49 167.4 11.3 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoctamin PF04547.12 ETO23310.1 - 5.9e-46 157.2 0.2 6.9e-46 157.0 0.2 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Kinesin PF00225.23 ETO23312.1 - 9.7e-10 37.9 0.0 1.3e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO23312.1 - 8.6e-07 29.0 0.0 2.1e-06 27.8 0.0 1.6 1 0 0 1 1 1 1 Microtubule binding SAM_1 PF00536.30 ETO23312.1 - 9e-06 26.0 0.0 1.8e-05 25.1 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO23312.1 - 1.5e-05 25.0 0.1 2.7e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO23312.1 - 0.11 12.8 0.0 0.25 11.6 0.0 1.5 1 0 0 1 1 1 0 Ste50p, sterile alpha motif Kinesin PF00225.23 ETO23313.1 - 4.5e-67 226.3 1.4 4.5e-67 226.3 1.4 2.0 2 1 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ETO23313.1 - 0.00024 21.1 1.8 0.0007 19.6 0.0 2.7 2 1 2 4 4 4 1 Microtubule binding DUF1786 PF08735.10 ETO23313.1 - 0.0092 15.3 0.1 0.016 14.5 0.1 1.4 1 0 0 1 1 1 1 Putative pyruvate format-lyase activating enzyme (DUF1786) Rad52_Rad22 PF04098.15 ETO23313.1 - 0.01 15.8 0.2 0.01 15.8 0.2 2.3 2 0 0 2 2 2 0 Rad52/22 family double-strand break repair protein Maelstrom PF13017.6 ETO23313.1 - 0.081 12.6 1.7 0.11 12.2 0.1 2.0 2 0 0 2 2 2 0 piRNA pathway germ-plasm component FHA PF00498.26 ETO23313.1 - 0.086 13.2 0.0 0.24 11.8 0.0 1.8 1 0 0 1 1 1 0 FHA domain IZUMO PF15005.6 ETO23313.1 - 0.17 12.4 6.2 0.12 12.8 3.4 2.2 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Glyco_hydro_38N PF01074.22 ETO23313.1 - 0.2 11.0 3.0 0.18 11.2 0.4 2.1 3 0 0 3 3 3 0 Glycosyl hydrolases family 38 N-terminal domain PH PF00169.29 ETO23314.1 - 0.00017 22.0 0.0 0.00055 20.4 0.0 1.8 1 0 0 1 1 1 1 PH domain LOH1CR12 PF10158.9 ETO23314.1 - 0.0094 16.0 0.3 0.016 15.2 0.3 1.3 1 0 0 1 1 1 1 Tumour suppressor protein Phage_tail_APC PF16778.5 ETO23314.1 - 0.081 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Phage tail assembly chaperone protein RabGAP-TBC PF00566.18 ETO23315.1 - 7.8e-19 68.2 6.8 1.4e-18 67.4 6.8 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF5643 PF18705.1 ETO23316.1 - 0.0029 17.5 0.4 0.0041 17.1 0.4 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5643) BspA_v PF18220.1 ETO23318.1 - 0.0031 17.7 3.9 0.0037 17.4 3.9 1.1 1 0 0 1 1 1 1 Adhesin BspA variable domain zf-RING_2 PF13639.6 ETO23319.1 - 1.8e-07 31.4 4.9 1.8e-07 31.4 4.9 7.9 8 2 0 8 8 8 2 Ring finger domain zf-RING_11 PF17123.5 ETO23319.1 - 0.014 15.2 3.5 0.014 15.2 3.5 4.5 5 0 0 5 5 5 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO23319.1 - 0.016 15.1 1.1 0.016 15.1 1.1 8.2 10 1 0 10 10 10 0 Zinc finger, C3HC4 type (RING finger) Gelsolin PF00626.22 ETO23321.1 - 6.9e-32 109.2 0.1 7.9e-11 41.7 0.0 3.6 3 0 0 3 3 3 3 Gelsolin repeat DASH_Spc19 PF08287.11 ETO23323.1 - 9.7 6.1 8.6 27 4.6 8.6 1.8 1 1 0 1 1 1 0 Spc19 Ras PF00071.22 ETO23324.1 - 3.2e-16 59.3 0.0 4.3e-16 58.9 0.0 1.3 1 1 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 ETO23324.1 - 0.0047 16.8 0.0 0.0056 16.6 0.0 1.1 1 0 0 1 1 1 1 RsgA GTPase HMG_box_5 PF14887.6 ETO23324.1 - 0.02 14.9 1.5 0.03 14.3 1.5 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box 5 DUF211 PF02680.14 ETO23324.1 - 0.081 13.1 0.0 0.11 12.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized ArCR, COG1888 WD40 PF00400.32 ETO23325.1 - 1.7e-08 34.9 1.5 0.077 13.9 0.0 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat N_BRCA1_IG PF16158.5 ETO23326.1 - 1.7e-24 86.5 0.0 4e-24 85.3 0.0 1.6 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 ETO23326.1 - 8.6e-08 31.9 1.4 2e-07 30.7 1.4 1.5 1 0 0 1 1 1 1 Zinc finger, ZZ type CLIP1_ZNF PF16641.5 ETO23326.1 - 0.0068 16.3 0.3 0.019 14.8 0.3 1.8 1 0 0 1 1 1 1 CLIP1 zinc knuckle NADH-G_4Fe-4S_3 PF10588.9 ETO23327.1 - 0.091 12.3 0.5 0.17 11.4 0.5 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region Trypan_PARP PF05887.11 ETO23328.1 - 0.17 11.9 0.7 0.28 11.2 0.7 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4663 PF15668.5 ETO23328.1 - 0.63 9.1 9.0 0.88 8.6 9.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4663) TFIIA PF03153.13 ETO23328.1 - 0.88 9.5 20.1 1.1 9.2 20.1 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit BUD22 PF09073.10 ETO23330.1 - 0.011 15.1 26.9 0.015 14.7 26.9 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO23330.1 - 0.087 11.0 30.0 0.11 10.8 30.0 1.3 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO23330.1 - 0.21 10.9 36.8 0.3 10.5 36.8 1.2 1 0 0 1 1 1 0 SDA1 Raftlin PF15250.6 ETO23330.1 - 0.82 8.4 12.0 0.94 8.2 12.0 1.3 1 0 0 1 1 1 0 Raftlin Nop53 PF07767.11 ETO23330.1 - 1.8 7.9 38.5 2.3 7.5 38.5 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) GREB1 PF15782.5 ETO23330.1 - 3.5 4.6 16.4 4 4.4 16.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 ETO23330.1 - 8 4.6 27.9 9.9 4.3 27.9 1.2 1 0 0 1 1 1 0 CDC45-like protein CAP_GLY PF01302.25 ETO23332.1 - 1.7e-10 40.8 0.1 2.4e-10 40.3 0.1 1.2 1 0 0 1 1 1 1 CAP-Gly domain THRAP3_BCLAF1 PF15440.6 ETO23333.1 - 0.021 13.8 22.0 0.024 13.7 22.0 1.1 1 0 0 1 1 1 0 THRAP3/BCLAF1 family PMP22_Claudin PF00822.20 ETO23333.1 - 0.042 13.7 0.1 0.08 12.8 0.1 1.4 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin family BUD22 PF09073.10 ETO23333.1 - 0.06 12.7 33.7 0.077 12.3 33.7 1.1 1 0 0 1 1 1 0 BUD22 DUF4446 PF14584.6 ETO23333.1 - 0.2 11.6 3.7 0.38 10.7 3.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Utp14 PF04615.13 ETO23333.1 - 0.21 10.1 29.3 0.25 9.9 29.3 1.1 1 0 0 1 1 1 0 Utp14 protein S_4TM PF18159.1 ETO23333.1 - 0.24 10.7 1.5 0.39 10.0 1.5 1.2 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain Shisa PF13908.6 ETO23333.1 - 0.26 11.5 12.6 0.7 10.1 12.6 1.8 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator CBP_BcsG PF11658.8 ETO23333.1 - 0.37 9.1 5.2 0.59 8.5 5.2 1.4 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG EMC3_TMCO1 PF01956.16 ETO23333.1 - 0.96 9.2 8.9 0.035 13.9 2.0 2.0 1 1 1 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CSG2 PF16965.5 ETO23333.1 - 1.9 7.4 13.1 3.4 6.5 13.1 1.5 1 1 0 1 1 1 0 Ceramide synthase regulator FPN1 PF06963.12 ETO23333.1 - 1.9 6.9 5.1 3.7 6.0 5.1 1.5 1 1 0 1 1 1 0 Ferroportin1 (FPN1) BSP_II PF05432.11 ETO23333.1 - 3.1 7.4 32.0 5.3 6.6 32.0 1.3 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) BAF1_ABF1 PF04684.13 ETO23333.1 - 8.8 5.3 29.1 11 4.9 29.1 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor LRR_9 PF14580.6 ETO23334.1 - 1.3e-08 34.6 2.1 2.6e-08 33.6 2.1 1.5 1 0 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ETO23334.1 - 0.0025 18.2 3.4 0.06 13.8 0.4 3.2 2 1 2 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO23334.1 - 0.024 14.4 2.1 0.12 12.2 0.5 2.4 2 0 0 2 2 2 0 Leucine rich repeat DUF1351 PF07083.11 ETO23334.1 - 0.13 12.0 3.8 0.042 13.6 1.1 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1351) MAM PF00629.23 ETO23336.1 - 0.036 14.0 4.1 0.053 13.4 3.9 1.3 1 1 0 1 1 1 0 MAM domain, meprin/A5/mu CdiA_C_tRNase PF18664.1 ETO23336.1 - 0.11 12.7 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 CdiA C-terminal tRNase domain WD40 PF00400.32 ETO23337.1 - 3.5e-12 46.6 12.0 0.00031 21.5 0.0 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23337.1 - 1.6e-10 41.1 1.2 0.00033 20.9 0.1 3.4 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO23337.1 - 0.00094 19.1 0.1 0.0075 16.2 0.0 2.3 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A PABP PF00658.18 ETO23339.1 - 7.8e-06 26.0 0.0 1.3e-05 25.3 0.0 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-C3HC4_3 PF13920.6 ETO23341.1 - 7.3e-10 38.5 9.4 7.3e-10 38.5 9.4 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO23341.1 - 8.1e-06 25.6 10.9 8.1e-06 25.6 10.9 1.9 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 Staph_opine_DH PF10100.9 ETO23341.1 - 0.049 12.3 0.0 0.07 11.8 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase zf-RING_5 PF14634.6 ETO23341.1 - 0.15 12.0 10.6 0.4 10.7 10.6 1.7 1 0 0 1 1 1 0 zinc-RING finger domain NS3_envE PF02723.14 ETO23341.1 - 3.2 7.9 6.0 4.8 7.3 0.0 3.2 3 0 0 3 3 3 0 Non-structural protein NS3/Small envelope protein E Zn_ribbon_2 PF12674.7 ETO23342.1 - 0.1 13.3 0.1 0.1 13.3 0.1 2.5 3 0 0 3 3 3 0 Putative zinc ribbon domain Voldacs PF03517.13 ETO23342.1 - 0.12 12.5 6.6 11 6.2 0.0 2.7 2 0 0 2 2 2 0 Regulator of volume decrease after cellular swelling CENP-B_dimeris PF09026.10 ETO23342.1 - 0.41 11.1 15.6 1.4 9.4 15.6 2.0 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO23342.1 - 2 6.4 12.8 0.18 9.9 7.3 1.8 2 0 0 2 2 2 0 DNA polymerase phi MAJIN PF15077.6 ETO23343.1 - 2.4 7.9 14.8 2.7 7.7 14.8 1.0 1 0 0 1 1 1 0 Membrane-anchored junction protein DUF3807 PF12720.7 ETO23343.1 - 6.6 7.0 25.1 8.5 6.6 25.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Dynactin PF12455.8 ETO23344.1 - 0.024 13.9 0.0 0.037 13.3 0.0 1.2 1 0 0 1 1 1 0 Dynein associated protein AAA_25 PF13481.6 ETO23344.1 - 0.04 13.5 0.0 0.087 12.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO23344.1 - 0.043 13.3 0.0 0.068 12.6 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein Cyt_bd_oxida_I PF01654.17 ETO23344.1 - 0.24 10.0 0.2 0.87 8.1 0.0 1.8 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit I Cyclin PF08613.11 ETO23345.1 - 1.9e-06 28.3 0.0 1.9e-06 28.3 0.0 2.6 3 0 0 3 3 3 1 Cyclin Cyclin_N PF00134.23 ETO23345.1 - 0.0017 18.1 0.1 0.0037 17.0 0.1 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Ank_2 PF12796.7 ETO23346.1 - 9.1e-21 74.3 7.1 3.3e-11 43.6 0.7 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO23346.1 - 2.8e-16 59.6 2.3 1.9e-08 34.7 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO23346.1 - 3.3e-16 59.1 6.4 8.1e-06 26.0 0.2 4.2 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO23346.1 - 2.3e-15 55.2 2.7 0.0038 17.6 0.0 4.5 4 0 0 4 4 4 3 Ankyrin repeat Ank PF00023.30 ETO23346.1 - 9.2e-12 44.9 6.3 0.00011 22.5 0.0 4.4 4 0 0 4 4 4 3 Ankyrin repeat Coat_F PF07875.12 ETO23346.1 - 0.16 12.2 1.1 18 5.7 0.0 3.3 3 0 0 3 3 3 0 Coat F domain Ncstrn_small PF18266.1 ETO23347.1 - 0.1 12.6 1.5 0.23 11.5 1.5 1.5 1 0 0 1 1 1 0 Nicastrin small lobe Tau95_N PF17682.1 ETO23348.1 - 6.1e-05 23.2 1.8 6.1e-05 23.2 1.8 2.7 2 1 0 2 2 2 1 Tau95 Triple barrel domain Band_3_cyto PF07565.13 ETO23348.1 - 2.3 8.0 5.1 0.36 10.6 0.3 1.8 1 1 1 2 2 2 0 Band 3 cytoplasmic domain Tau95 PF09734.9 ETO23349.1 - 2.2e-17 64.2 0.5 3e-17 63.7 0.5 1.4 1 1 0 1 1 1 1 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain TFIIF_beta PF02270.15 ETO23349.1 - 0.077 13.1 0.1 0.17 12.0 0.1 1.6 1 1 0 1 1 1 0 TFIIF, beta subunit HTH domain RXT2_N PF08595.11 ETO23349.1 - 0.085 12.9 3.8 0.13 12.3 3.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal VWA PF00092.28 ETO23351.1 - 1e-09 38.9 0.0 1.8e-09 38.1 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO23351.1 - 4e-08 33.3 0.0 7.2e-08 32.5 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO23351.1 - 8.1e-07 29.7 0.0 1.8e-06 28.5 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VIT PF08487.10 ETO23351.1 - 0.00094 19.4 0.1 0.0037 17.5 0.0 2.0 2 0 0 2 2 2 1 Vault protein inter-alpha-trypsin domain DUF2721 PF11026.8 ETO23352.1 - 0.021 14.7 0.1 0.021 14.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) WASH-7_mid PF14744.6 ETO23353.1 - 1.7e-110 369.4 19.0 1.5e-84 284.1 6.2 4.4 3 1 1 4 4 4 4 WASH complex subunit 7 WASH-7_N PF14745.6 ETO23353.1 - 9.4e-48 163.1 24.5 2.3e-24 85.9 8.6 3.2 2 1 0 2 2 2 2 WASH complex subunit 7, N-terminal WASH-7_C PF14746.6 ETO23354.1 - 5.8e-33 114.0 0.1 7.8e-33 113.6 0.1 1.2 1 0 0 1 1 1 1 WASH complex subunit 7, C-terminal C2 PF00168.30 ETO23355.1 - 1.2e-24 86.6 0.1 3.9e-24 84.9 0.0 1.8 2 0 0 2 2 2 1 C2 domain DUF2277 PF10041.9 ETO23355.1 - 0.057 13.7 0.4 10 6.5 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2277) CEP76-C2 PF15627.6 ETO23355.1 - 0.057 13.0 0.0 0.15 11.6 0.0 1.7 1 0 0 1 1 1 0 CEP76 C2 domain 2OG-FeII_Oxy_4 PF13661.6 ETO23355.1 - 0.077 13.7 0.1 0.18 12.5 0.1 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily WD40 PF00400.32 ETO23357.1 - 2e-41 139.2 32.3 9.6e-08 32.6 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23357.1 - 9.3e-12 45.1 4.2 0.82 10.0 0.0 5.6 3 2 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23357.1 - 3.3e-10 39.2 11.3 0.054 12.1 0.1 5.9 2 2 3 6 6 6 6 Nucleoporin Nup120/160 WD40 PF00400.32 ETO23358.1 - 2.2e-43 145.4 30.9 4.8e-07 30.4 0.4 7.4 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23358.1 - 2.2e-14 53.5 4.2 0.0085 16.4 0.0 5.9 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23358.1 - 1.2e-11 43.9 7.9 0.00036 19.3 0.1 5.3 1 1 3 5 5 5 5 Nucleoporin Nup120/160 Arena_nucleocap PF00843.17 ETO23358.1 - 0.014 14.3 0.3 0.33 9.8 0.0 3.0 1 1 3 4 4 4 0 Arenavirus nucleocapsid N-terminal domain Phage_head_fibr PF11133.8 ETO23358.1 - 0.044 13.2 0.0 8.2 5.7 0.0 3.3 3 1 1 4 4 4 0 Head fiber protein zf-TRAF PF02176.18 ETO23359.1 - 0.00017 22.2 5.4 0.00017 22.2 5.4 2.2 2 1 0 2 2 2 1 TRAF-type zinc finger zf-C3HC4_5 PF17121.5 ETO23359.1 - 0.048 13.5 1.8 0.079 12.9 0.7 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF812 PF05667.11 ETO23360.1 - 0.0035 16.3 6.6 0.0035 16.3 6.6 4.8 2 2 2 5 5 5 2 Protein of unknown function (DUF812) RR_TM4-6 PF06459.12 ETO23362.1 - 0.0056 16.5 2.3 0.0067 16.3 2.3 1.1 1 0 0 1 1 1 1 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO23362.1 - 0.016 13.6 1.8 0.017 13.4 1.8 1.0 1 0 0 1 1 1 0 CDC45-like protein ETRAMP PF09716.10 ETO23362.1 - 0.65 10.1 9.0 1.2 9.2 9.0 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) SRP-alpha_N PF04086.13 ETO23362.1 - 4.3 7.2 12.7 5.5 6.8 12.7 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Sfi1_C PF10638.9 ETO23363.1 - 0.0039 17.9 1.5 0.017 15.9 0.3 2.3 1 1 1 2 2 2 1 Spindle body associated protein C-terminus Peptidase_M17_N PF02789.17 ETO23363.1 - 0.014 15.3 0.0 0.02 14.7 0.0 1.3 1 0 0 1 1 1 0 Cytosol aminopeptidase family, N-terminal domain GWT1 PF06423.12 ETO23365.1 - 8.1e-26 90.9 13.6 8.1e-26 90.9 13.6 2.5 3 1 0 3 3 3 1 GWT1 Ank_2 PF12796.7 ETO23366.1 - 2.3e-29 101.8 2.6 6.8e-11 42.6 0.0 4.5 2 2 2 4 4 4 4 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO23366.1 - 1.4e-20 73.1 0.6 2.3e-06 27.8 0.0 5.7 4 1 1 5 5 5 4 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO23366.1 - 1.3e-17 63.9 1.4 0.00013 22.4 0.1 5.0 5 0 0 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 ETO23366.1 - 2.9e-17 62.2 0.8 0.0021 18.4 0.0 6.5 6 1 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 ETO23366.1 - 1.9e-15 55.4 4.6 0.35 11.6 0.0 7.8 7 0 0 7 7 7 4 Ankyrin repeat KleE PF17394.2 ETO23368.1 - 0.063 13.5 2.1 0.14 12.4 2.0 1.7 1 1 0 1 1 1 0 Uncharacterized KleE stable inheritance protein HTH_49 PF18010.1 ETO23371.1 - 0.028 14.2 0.1 0.077 12.9 0.1 1.7 2 0 0 2 2 2 0 Cry35Ab1 HTH C-terminal domain zf_Hakai PF18408.1 ETO23371.1 - 0.047 13.4 0.2 0.11 12.2 0.2 1.6 1 0 0 1 1 1 0 C2H2 Hakai zinc finger domain RasGEF_N PF00618.20 ETO23371.1 - 0.15 12.3 1.7 0.21 11.8 1.7 1.4 1 1 0 1 1 1 0 RasGEF N-terminal motif KR PF08659.10 ETO23372.1 - 0.49 10.3 2.6 1.3 8.9 0.5 2.6 2 1 0 2 2 2 0 KR domain ATG16 PF08614.11 ETO23372.1 - 0.83 9.8 56.3 1.4 9.1 24.4 3.7 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) DUF2024 PF09630.10 ETO23373.1 - 0.11 12.4 1.3 0.39 10.6 1.3 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF2024) PTH2 PF01981.16 ETO23373.1 - 1.6 9.1 6.7 0.25 11.6 0.8 2.6 2 1 1 3 3 3 0 Peptidyl-tRNA hydrolase PTH2 PH PF00169.29 ETO23374.1 - 2.2e-09 37.8 0.0 2.2e-09 37.8 0.0 1.5 2 0 0 2 2 2 1 PH domain GTP_cyclohydroI PF01227.22 ETO23375.1 - 1.5e-62 210.2 0.6 2e-62 209.8 0.6 1.2 1 0 0 1 1 1 1 GTP cyclohydrolase I QueF PF14489.6 ETO23375.1 - 0.027 14.6 0.0 0.058 13.6 0.0 1.5 1 0 0 1 1 1 0 QueF-like protein CAP_GLY PF01302.25 ETO23376.1 - 5.8e-12 45.5 0.1 9.7e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 CAP-Gly domain XhoI PF04555.13 ETO23377.1 - 0.034 14.0 0.1 0.064 13.2 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease XhoI DUF4381 PF14316.6 ETO23377.1 - 0.13 12.5 0.1 0.21 11.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Comm PF15957.5 ETO23377.1 - 0.52 10.7 0.0 0.52 10.7 0.0 2.2 2 1 0 2 2 2 0 Commissureless CLASP_N PF12348.8 ETO23378.1 - 5.6e-16 58.8 7.6 9.6e-10 38.4 3.1 3.4 2 1 0 2 2 2 2 CLASP N terminal B56 PF01603.20 ETO23379.1 - 3e-64 217.5 11.6 6.5e-63 213.1 11.6 2.2 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) CAP_GLY PF01302.25 ETO23379.1 - 8.5e-23 80.2 7.6 6.7e-22 77.3 0.3 2.8 3 0 0 3 3 3 2 CAP-Gly domain Vac14_Fab1_bd PF12755.7 ETO23379.1 - 0.044 14.4 0.2 0.21 12.2 0.2 2.2 1 1 1 2 2 2 0 Vacuolar 14 Fab1-binding region SDA1 PF05285.12 ETO23379.1 - 2.9 7.2 38.0 3.1 7.2 28.4 2.5 2 0 0 2 2 2 0 SDA1 Glyoxalase PF00903.25 ETO23380.1 - 2.1e-15 57.0 0.5 5.4e-15 55.7 0.1 1.9 2 0 0 2 2 2 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ETO23380.1 - 5.7e-08 33.0 0.1 6.5e-05 23.2 0.1 2.4 2 0 0 2 2 2 2 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_5 PF14696.6 ETO23380.1 - 0.00071 19.8 0.0 0.0067 16.6 0.0 2.1 2 0 0 2 2 2 1 Hydroxyphenylpyruvate dioxygenase, HPPD, N-terminal DNA_primase_S PF01896.19 ETO23380.1 - 0.038 14.0 0.0 0.086 12.9 0.0 1.6 1 1 0 1 1 1 0 DNA primase small subunit Glyoxalase_3 PF13468.6 ETO23380.1 - 0.1 12.7 0.1 0.48 10.5 0.1 2.1 1 1 0 1 1 1 0 Glyoxalase-like domain Pox_A28 PF04584.14 ETO23380.1 - 0.14 12.4 0.1 2.7 8.2 0.0 2.2 2 0 0 2 2 2 0 Poxvirus A28 family SAM_1 PF00536.30 ETO23381.1 - 4.1e-08 33.6 0.2 7e-08 32.8 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO23381.1 - 8.1e-08 32.3 0.2 1.2e-07 31.7 0.2 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF494 PF04361.13 ETO23382.1 - 0.11 12.4 0.0 0.15 11.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF494) SOBP PF15279.6 ETO23383.1 - 0.23 12.0 12.6 0.3 11.7 12.6 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein zf-CCHC_3 PF13917.6 ETO23383.1 - 2.7 8.0 9.3 2.7 8.0 0.1 3.4 3 1 1 4 4 4 0 Zinc knuckle Importin_rep PF18773.1 ETO23384.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Importin 13 repeat Exo_endo_phos PF03372.23 ETO23385.1 - 0.0002 20.9 0.0 0.00025 20.7 0.0 1.2 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TFR_dimer PF04253.15 ETO23386.1 - 1.8e-09 37.8 0.0 2.4e-09 37.4 0.0 1.2 1 0 0 1 1 1 1 Transferrin receptor-like dimerisation domain Peptidase_C92 PF05708.12 ETO23386.1 - 0.027 14.6 0.0 0.073 13.2 0.0 1.7 2 0 0 2 2 2 0 Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family FapA PF03961.13 ETO23387.1 - 0.0042 15.8 7.8 0.0042 15.8 7.8 2.1 1 1 1 2 2 2 1 Flagellar Assembly Protein A BBP1_C PF15272.6 ETO23387.1 - 0.005 16.7 8.5 0.005 16.7 8.5 2.9 1 1 1 2 2 2 1 Spindle pole body component BBP1, C-terminal Ead_Ea22 PF13935.6 ETO23387.1 - 0.016 15.9 1.0 0.016 15.9 1.0 2.2 1 1 1 2 2 2 0 Ead/Ea22-like protein Uso1_p115_C PF04871.13 ETO23387.1 - 0.018 15.4 7.3 0.018 15.4 7.3 2.7 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region OEP PF02321.18 ETO23387.1 - 0.033 14.0 6.2 0.18 11.6 0.4 2.3 2 0 0 2 2 2 0 Outer membrane efflux protein Cob_adeno_trans PF01923.18 ETO23387.1 - 0.053 13.7 9.9 0.33 11.1 2.6 2.3 1 1 1 2 2 2 0 Cobalamin adenosyltransferase K-box PF01486.17 ETO23387.1 - 0.063 13.5 1.4 0.063 13.5 1.4 3.8 3 1 0 3 3 3 0 K-box region GTP-bdg_M PF16360.5 ETO23387.1 - 0.084 13.5 10.2 3.5 8.3 0.3 3.4 3 0 0 3 3 3 0 GTP-binding GTPase Middle Region ApoO PF09769.9 ETO23387.1 - 0.14 12.1 6.5 0.12 12.4 1.5 2.6 1 1 1 2 2 2 0 Apolipoprotein O DivIC PF04977.15 ETO23387.1 - 0.19 11.6 0.1 0.19 11.6 0.1 3.8 3 1 1 4 4 4 0 Septum formation initiator F_actin_bind PF08919.10 ETO23387.1 - 0.24 11.5 0.1 0.24 11.5 0.1 3.4 1 1 3 4 4 4 0 F-actin binding DUF4407 PF14362.6 ETO23387.1 - 0.26 10.6 15.1 0.68 9.2 11.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) PilJ PF13675.6 ETO23387.1 - 0.31 11.1 7.4 1.6 8.8 5.2 2.7 1 1 1 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term HR1 PF02185.16 ETO23387.1 - 0.35 11.0 24.6 0.37 10.9 1.0 4.4 3 2 1 4 4 4 0 Hr1 repeat Pox_A_type_inc PF04508.12 ETO23387.1 - 0.65 9.9 7.1 5.3 7.1 0.6 3.3 4 0 0 4 4 3 0 Viral A-type inclusion protein repeat DUF2408 PF10303.9 ETO23387.1 - 0.9 10.1 18.1 0.099 13.2 6.9 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Tho2 PF11262.8 ETO23387.1 - 0.9 8.7 16.8 1.4 8.1 6.5 2.6 1 1 2 3 3 3 0 Transcription factor/nuclear export subunit protein 2 Jnk-SapK_ap_N PF09744.9 ETO23387.1 - 1.1 9.5 33.9 5.8 7.1 3.2 3.0 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 GreA_GreB_N PF03449.15 ETO23387.1 - 1.2 9.3 12.8 1.6 9.0 6.2 3.4 2 1 1 3 3 3 0 Transcription elongation factor, N-terminal OmpH PF03938.14 ETO23387.1 - 1.7 9.0 27.1 0.23 11.8 11.3 2.6 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) TMF_TATA_bd PF12325.8 ETO23387.1 - 2 8.6 27.3 1.6 9.0 1.4 3.4 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding Fungal_TACC PF12709.7 ETO23387.1 - 2.4 8.7 23.1 0.35 11.3 1.3 3.8 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Fib_alpha PF08702.10 ETO23387.1 - 2.7 8.2 20.2 0.51 10.5 8.7 2.6 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family FAM184 PF15665.5 ETO23387.1 - 2.9 7.6 28.6 3.4e+02 0.8 28.6 2.1 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B ParB PF08775.10 ETO23387.1 - 3.4 8.2 13.3 1.3 9.5 0.6 3.2 1 1 1 3 3 3 0 ParB family CLZ PF16526.5 ETO23387.1 - 4 7.9 21.1 0.5 10.8 1.3 3.6 3 1 1 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF4515 PF14988.6 ETO23387.1 - 4.4 7.1 31.9 0.58 10.0 4.2 3.2 1 1 1 3 3 3 0 Domain of unknown function (DUF4515) DUF3584 PF12128.8 ETO23387.1 - 5.6 4.3 26.5 0.35 8.3 10.5 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) DUF3450 PF11932.8 ETO23387.1 - 6.3 6.0 25.1 0.1 11.9 4.5 3.3 1 1 2 3 3 3 0 Protein of unknown function (DUF3450) Fzo_mitofusin PF04799.13 ETO23387.1 - 6.7 6.2 18.2 0.57 9.7 1.6 3.1 1 1 2 3 3 3 0 fzo-like conserved region Baculo_p24 PF05073.12 ETO23387.1 - 8.6 6.1 12.3 73 3.1 12.3 2.1 1 1 0 1 1 1 0 Baculovirus P24 capsid protein FUSC PF04632.12 ETO23387.1 - 8.7 4.7 5.7 7.6 4.9 4.3 1.5 1 1 0 1 1 1 0 Fusaric acid resistance protein family GARP PF16731.5 ETO23387.1 - 9.1 5.9 11.7 5.3e+02 0.2 11.6 2.9 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma Ion_trans PF00520.31 ETO23388.1 - 6.7e-32 110.7 43.2 1.3e-22 80.3 29.4 2.3 2 0 0 2 2 2 2 Ion transport protein 7tm_1 PF00001.21 ETO23388.1 - 0.00015 21.2 0.0 0.011 15.0 0.0 2.9 1 1 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Peptidase_S49_N PF08496.10 ETO23388.1 - 0.37 10.8 10.0 2.1 8.4 1.3 2.9 3 0 0 3 3 3 0 Peptidase family S49 N-terminal WD40 PF00400.32 ETO23390.1 - 6.4e-30 102.8 25.1 2.3e-06 28.2 0.4 6.9 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23390.1 - 6.6e-13 48.8 1.6 0.099 13.0 0.0 5.8 3 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23390.1 - 2.4e-12 46.3 2.5 0.00016 20.5 0.1 4.6 1 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO23390.1 - 4.1e-06 26.3 6.9 0.75 9.1 0.0 5.4 2 2 4 6 6 6 3 WD40-like domain DUF1195 PF06708.11 ETO23391.1 - 0.062 13.1 0.4 0.13 12.1 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1195) eIF-3c_N PF05470.12 ETO23391.1 - 0.12 10.7 14.3 0.15 10.3 14.3 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus INSIG PF07281.12 ETO23391.1 - 0.64 9.6 2.8 0.84 9.2 2.8 1.5 1 1 0 1 1 1 0 Insulin-induced protein (INSIG) Kei1 PF08552.11 ETO23391.1 - 1.8 8.4 3.7 3.2 7.6 0.4 2.1 2 0 0 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 RNase_J_C PF17770.1 ETO23391.1 - 3.1 8.9 7.2 29 5.8 0.2 3.2 2 1 1 3 3 3 0 Ribonuclease J C-terminal domain Med19 PF10278.9 ETO23391.1 - 5 7.0 16.7 2.3 8.1 12.3 2.0 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 PITH PF06201.13 ETO23392.1 - 2.6e-16 60.2 0.1 3.9e-16 59.6 0.1 1.2 1 0 0 1 1 1 1 PITH domain Peptidase_C97 PF05903.14 ETO23392.1 - 0.017 15.0 0.0 0.033 14.0 0.0 1.5 1 0 0 1 1 1 0 PPPDE putative peptidase domain FAM150 PF15129.6 ETO23394.1 - 2.1 8.5 8.0 0.092 12.9 0.8 2.4 2 0 0 2 2 2 0 FAM150 family PT PF04886.12 ETO23395.1 - 1.4e-11 43.7 141.5 0.018 14.6 13.3 7.0 1 1 3 4 4 4 2 PT repeat Zip PF02535.22 ETO23397.1 - 0.0038 16.5 1.7 0.005 16.1 1.7 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter CLN3 PF02487.17 ETO23397.1 - 0.0048 16.0 1.0 0.0048 16.0 1.0 1.6 1 1 1 2 2 2 1 CLN3 protein CDC45 PF02724.14 ETO23397.1 - 0.085 11.1 13.0 0.097 11.0 13.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Ureide_permease PF07168.11 ETO23397.1 - 0.089 11.5 6.9 0.13 11.0 6.9 1.4 1 1 0 1 1 1 0 Ureide permease Mem_trans PF03547.18 ETO23397.1 - 0.093 11.1 1.0 0.11 10.9 1.0 1.2 1 0 0 1 1 1 0 Membrane transport protein SID-1_RNA_chan PF13965.6 ETO23397.1 - 0.28 9.5 3.7 0.33 9.3 3.7 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ctr PF04145.15 ETO23397.1 - 6.7 7.3 7.9 17 6.0 7.9 1.8 1 1 0 1 1 1 0 Ctr copper transporter family bacHORMA_1 PF18138.1 ETO23399.1 - 0.0041 17.0 0.2 0.0078 16.1 0.2 1.4 1 0 0 1 1 1 1 Bacterial HORMA domain family 1 Mur_ligase_M PF08245.12 ETO23399.1 - 0.021 14.8 0.3 0.035 14.1 0.2 1.3 1 1 0 1 1 1 0 Mur ligase middle domain BK_channel_a PF03493.18 ETO23399.1 - 0.042 14.0 0.8 0.071 13.3 0.8 1.5 1 1 0 1 1 1 0 Calcium-activated BK potassium channel alpha subunit DEAD PF00270.29 ETO23400.1 - 4e-32 111.4 0.0 1.1e-30 106.7 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO23400.1 - 3e-31 108.0 0.0 7.2e-30 103.6 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ETO23400.1 - 0.1 11.9 0.0 0.18 11.1 0.0 1.3 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Kelch_3 PF13415.6 ETO23401.1 - 5e-21 74.5 3.2 7.3e-09 35.7 0.2 3.3 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO23401.1 - 1.1e-17 63.7 6.2 1.3e-09 37.9 0.7 4.1 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO23401.1 - 1.9e-14 53.3 3.3 2.3e-06 27.7 0.3 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO23401.1 - 1.1e-11 44.1 2.7 2.5e-05 23.7 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO23401.1 - 1.7e-11 43.8 7.2 3.8e-09 36.3 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO23401.1 - 1.2e-10 41.0 1.4 0.0013 18.6 0.2 3.6 4 0 0 4 4 4 2 Kelch motif DUF1980 PF09323.10 ETO23401.1 - 1.9 8.4 6.4 1.1 9.1 3.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) ALMT PF11744.8 ETO23401.1 - 2 7.2 6.5 2.6 6.8 6.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF936 PF06075.12 ETO23402.1 - 5.5 5.8 37.8 7 5.4 37.8 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) EF-hand_1 PF00036.32 ETO23403.1 - 2.5e-06 26.6 1.8 5.6e-06 25.5 0.7 2.3 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 ETO23403.1 - 2.9e-06 26.5 1.6 1.2e-05 24.6 1.6 2.1 1 0 0 1 1 1 1 EF hand EF-hand_7 PF13499.6 ETO23403.1 - 6.1e-05 23.4 10.8 0.0017 18.8 0.6 2.8 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO23403.1 - 0.00014 21.6 0.2 0.00054 19.8 0.2 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO23403.1 - 0.00063 19.5 0.9 0.0039 17.0 0.5 2.5 2 1 0 2 2 2 1 EF-hand domain SR-25 PF10500.9 ETO23403.1 - 0.016 14.8 17.3 0.024 14.2 17.3 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein EF-hand_4 PF12763.7 ETO23403.1 - 0.074 13.0 0.5 0.15 12.0 0.5 1.6 1 1 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand RNA_pol_Rpc4 PF05132.14 ETO23403.1 - 2.1 8.7 9.9 3 8.3 9.9 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETO23403.1 - 3.8 6.2 6.9 5.2 5.7 6.9 1.3 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 ETO23403.1 - 4.1 6.7 6.8 5.4 6.3 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RPN2_C PF18004.1 ETO23403.1 - 4.8 7.1 18.7 7.2 6.5 18.7 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Vac_Fusion PF02346.16 ETO23404.1 - 8.8 6.0 8.2 2 8.1 3.1 2.4 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Phage_Gp23 PF10669.9 ETO23404.1 - 9.2 6.6 14.0 7.9 6.8 10.5 2.0 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) DUSP PF06337.12 ETO23407.1 - 5.8e-18 65.3 1.3 2.7e-16 59.9 1.2 2.3 2 0 0 2 2 2 2 DUSP domain Claudin_2 PF13903.6 ETO23408.1 - 0.0058 16.4 0.1 0.0067 16.2 0.1 1.1 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction EMP70 PF02990.16 ETO23408.1 - 0.025 13.3 1.9 0.029 13.1 1.9 1.0 1 0 0 1 1 1 0 Endomembrane protein 70 Anoctamin PF04547.12 ETO23408.1 - 0.053 12.3 2.2 0.058 12.2 2.2 1.0 1 0 0 1 1 1 0 Calcium-activated chloride channel MAP17 PF15807.5 ETO23408.1 - 1.2 9.4 10.1 0.14 12.4 1.3 2.1 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF3810 PF12725.7 ETO23408.1 - 2 7.7 7.6 2.1 7.6 7.1 1.2 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) Orf78 PF06024.12 ETO23408.1 - 2.5 8.4 12.4 0.22 11.8 2.3 2.0 1 1 1 2 2 2 0 Orf78 (ac78) peroxidase PF00141.23 ETO23409.1 - 2.2e-39 135.5 0.0 2.8e-39 135.2 0.0 1.1 1 0 0 1 1 1 1 Peroxidase MAP70 PF07058.11 ETO23409.1 - 0.028 13.2 0.0 0.037 12.8 0.0 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 G-alpha PF00503.20 ETO23410.1 - 1.5e-20 73.6 7.5 1.5e-18 67.1 0.2 2.6 3 0 0 3 3 3 2 G-protein alpha subunit Arf PF00025.21 ETO23410.1 - 0.00096 18.6 0.3 0.0023 17.4 0.3 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family Secretin_N_2 PF07655.13 ETO23410.1 - 1.6 9.4 6.4 2.8 8.5 4.5 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain HOOK PF05622.12 ETO23411.1 - 3.7e-07 28.7 11.6 3.7e-07 28.7 11.6 2.0 1 1 1 2 2 2 1 HOOK protein KASH_CCD PF14662.6 ETO23411.1 - 0.00014 21.8 17.3 0.031 14.1 5.0 2.3 1 1 1 2 2 2 2 Coiled-coil region of CCDC155 or KASH ADIP PF11559.8 ETO23411.1 - 0.00036 20.6 18.8 0.005 16.9 10.1 2.2 1 1 1 2 2 2 2 Afadin- and alpha -actinin-Binding Tropomyosin_1 PF12718.7 ETO23411.1 - 0.00041 20.5 31.9 0.0067 16.6 12.5 2.1 1 1 1 2 2 2 2 Tropomyosin like GAS PF13851.6 ETO23411.1 - 0.00052 19.4 13.9 0.00052 19.4 13.9 2.2 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.21 ETO23411.1 - 0.0021 18.1 22.4 0.018 15.1 3.6 3.1 3 1 0 3 3 2 2 bZIP transcription factor Spc7 PF08317.11 ETO23411.1 - 0.0024 16.8 22.1 0.12 11.2 6.6 2.0 1 1 1 2 2 2 2 Spc7 kinetochore protein UPF0242 PF06785.11 ETO23411.1 - 0.0034 17.5 18.3 0.0049 17.0 18.3 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ETO23411.1 - 0.0039 16.3 8.6 0.0039 16.3 8.6 2.0 1 1 1 2 2 2 1 Vacuolar sorting 38 and autophagy-related subunit 14 HAP1_N PF04849.13 ETO23411.1 - 0.0041 16.4 14.9 0.011 14.9 14.9 1.7 1 1 0 1 1 1 1 HAP1 N-terminal conserved region TPR_MLP1_2 PF07926.12 ETO23411.1 - 0.0055 16.8 13.0 0.0055 16.8 13.0 2.2 1 1 1 2 2 2 2 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 ETO23411.1 - 0.0085 16.3 18.9 0.019 15.2 10.6 2.6 1 1 2 3 3 2 1 TATA element modulatory factor 1 TATA binding Shugoshin_N PF07558.11 ETO23411.1 - 0.0092 15.8 6.1 1.3 8.9 0.4 2.8 2 0 0 2 2 2 2 Shugoshin N-terminal coiled-coil region Filament PF00038.21 ETO23411.1 - 0.011 15.3 20.4 0.066 12.8 3.4 2.2 1 1 1 2 2 2 0 Intermediate filament protein Leu_zip PF15294.6 ETO23411.1 - 0.013 15.0 8.0 0.013 15.0 8.0 2.0 1 1 1 2 2 2 0 Leucine zipper Cnn_1N PF07989.11 ETO23411.1 - 0.014 15.5 17.4 0.19 11.9 0.8 3.3 1 1 1 3 3 3 0 Centrosomin N-terminal motif 1 Sec34 PF04136.15 ETO23411.1 - 0.015 15.2 8.3 0.028 14.3 1.8 2.4 1 1 1 2 2 2 0 Sec34-like family ATG16 PF08614.11 ETO23411.1 - 0.018 15.3 23.8 0.64 10.2 5.9 2.2 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) ZapB PF06005.12 ETO23411.1 - 0.018 15.5 19.5 0.043 14.3 11.5 3.1 1 1 1 2 2 2 0 Cell division protein ZapB Tropomyosin PF00261.20 ETO23411.1 - 0.03 13.7 19.4 0.21 11.0 14.6 2.8 1 1 1 2 2 2 0 Tropomyosin DUF2353 PF09789.9 ETO23411.1 - 0.035 13.5 20.2 0.013 14.8 8.9 2.0 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) BLOC1_2 PF10046.9 ETO23411.1 - 0.038 14.3 11.3 0.039 14.3 2.7 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TSC22 PF01166.18 ETO23411.1 - 0.052 13.9 9.4 0.78 10.1 0.4 3.4 2 2 1 3 3 3 0 TSC-22/dip/bun family SlyX PF04102.12 ETO23411.1 - 0.056 14.1 17.4 0.44 11.2 3.8 3.9 1 1 3 4 4 4 0 SlyX Exonuc_VII_L PF02601.15 ETO23411.1 - 0.056 13.0 13.6 0.065 12.8 13.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FlaC_arch PF05377.11 ETO23411.1 - 0.067 13.6 16.1 7.5 7.0 1.8 3.7 1 1 2 3 3 3 0 Flagella accessory protein C (FlaC) DUF724 PF05266.14 ETO23411.1 - 0.071 12.9 19.1 0.069 13.0 9.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) BRE1 PF08647.11 ETO23411.1 - 0.075 13.1 21.7 0.85 9.7 3.4 2.7 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3450 PF11932.8 ETO23411.1 - 0.081 12.2 15.6 0.18 11.1 7.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) KLRAQ PF10205.9 ETO23411.1 - 0.095 13.0 20.4 0.12 12.7 7.4 3.0 1 1 2 3 3 3 0 Predicted coiled-coil domain-containing protein APG6_N PF17675.1 ETO23411.1 - 0.1 13.1 19.9 0.64 10.6 10.6 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region PEARLI-4 PF05278.12 ETO23411.1 - 0.12 12.0 15.4 0.24 11.0 4.1 2.0 1 1 1 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) Fez1 PF06818.15 ETO23411.1 - 0.15 12.5 17.9 0.15 12.5 16.9 1.5 1 1 0 1 1 1 0 Fez1 DUF4763 PF15960.5 ETO23411.1 - 0.16 11.3 13.4 0.19 11.0 0.5 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Cauli_AT PF03233.13 ETO23411.1 - 0.16 11.9 11.6 1.3 8.9 2.4 2.3 1 1 1 2 2 2 0 Aphid transmission protein HemX PF04375.14 ETO23411.1 - 0.16 11.2 16.0 0.071 12.4 4.3 2.0 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Phlebovirus_NSM PF07246.11 ETO23411.1 - 0.17 11.2 16.6 0.03 13.7 8.9 2.0 1 1 1 2 2 2 0 Phlebovirus nonstructural protein NS-M YabA PF06156.13 ETO23411.1 - 0.18 12.5 15.1 0.71 10.5 2.1 3.1 1 1 2 3 3 3 0 Initiation control protein YabA DUF2205 PF10224.9 ETO23411.1 - 0.19 11.8 13.9 2.3 8.3 1.1 2.8 1 1 2 3 3 3 0 Short coiled-coil protein DUF4200 PF13863.6 ETO23411.1 - 0.22 11.9 21.4 0.28 11.6 10.0 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) HAUS-augmin3 PF14932.6 ETO23411.1 - 0.29 10.7 13.5 0.22 11.0 11.8 1.7 1 1 1 2 2 2 0 HAUS augmin-like complex subunit 3 TMF_DNA_bd PF12329.8 ETO23411.1 - 0.29 11.1 24.4 0.33 11.0 1.9 3.0 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Fib_alpha PF08702.10 ETO23411.1 - 0.33 11.1 14.1 0.18 12.0 10.5 2.0 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family FlxA PF14282.6 ETO23411.1 - 0.37 10.8 18.8 0.037 14.0 8.6 3.1 2 2 0 2 2 2 0 FlxA-like protein Prefoldin PF02996.17 ETO23411.1 - 0.4 10.6 13.1 1 9.3 1.3 3.1 2 1 1 3 3 3 0 Prefoldin subunit DUF5082 PF16888.5 ETO23411.1 - 0.41 10.9 13.1 12 6.2 2.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5082) DUF4315 PF14193.6 ETO23411.1 - 0.44 10.6 17.9 1.3 9.1 1.1 3.9 3 2 1 4 4 3 0 Domain of unknown function (DUF4315) HrpB7 PF09486.10 ETO23411.1 - 0.45 10.9 11.9 0.078 13.4 3.1 2.8 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Ax_dynein_light PF10211.9 ETO23411.1 - 0.47 10.4 18.2 0.22 11.4 1.6 3.1 1 1 2 3 3 3 0 Axonemal dynein light chain GIT_CC PF16559.5 ETO23411.1 - 0.52 10.2 17.6 0.18 11.7 2.2 3.6 3 1 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor Uso1_p115_C PF04871.13 ETO23411.1 - 0.54 10.6 22.3 0.068 13.5 10.1 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1515 PF07439.11 ETO23411.1 - 0.56 10.3 10.9 0.93 9.5 2.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) Jnk-SapK_ap_N PF09744.9 ETO23411.1 - 0.6 10.3 20.1 0.21 11.8 9.8 2.5 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF773 PF05600.12 ETO23411.1 - 0.61 8.8 15.8 2.2 6.9 3.1 2.2 1 1 1 2 2 2 0 CDK5 regulatory subunit-associated protein 3 Syntaxin-6_N PF09177.11 ETO23411.1 - 0.62 10.7 13.1 1.7 9.3 8.1 2.8 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Nup54 PF13874.6 ETO23411.1 - 0.69 10.0 13.2 0.85 9.7 9.0 2.1 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.12 ETO23411.1 - 0.69 10.4 7.5 3.7 8.1 1.9 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein CENP-F_leu_zip PF10473.9 ETO23411.1 - 0.8 9.7 21.8 0.16 12.0 8.5 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 ETO23411.1 - 0.83 9.9 17.4 0.11 12.7 7.1 2.4 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain AAA_13 PF13166.6 ETO23411.1 - 0.85 8.2 13.3 3.1 6.3 13.3 1.9 1 1 0 1 1 1 0 AAA domain DUF4472 PF14739.6 ETO23411.1 - 1.2 9.9 14.8 0.84 10.4 5.4 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) CALCOCO1 PF07888.11 ETO23411.1 - 1.4 7.7 21.7 1.6 7.5 21.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Spc24 PF08286.11 ETO23411.1 - 1.5 9.1 18.9 1.5 9.1 3.1 3.4 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 JIP_LZII PF16471.5 ETO23411.1 - 1.6 9.0 13.6 1.5 9.1 4.1 3.0 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II DUF4407 PF14362.6 ETO23411.1 - 1.6 8.0 14.2 6.9 5.9 14.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) MPS2 PF17060.5 ETO23411.1 - 2 7.6 14.1 5.4 6.2 14.1 1.7 1 1 0 1 1 1 0 Monopolar spindle protein 2 FAM76 PF16046.5 ETO23411.1 - 2.5 7.4 16.7 0.54 9.6 8.5 2.2 1 1 1 2 2 2 0 FAM76 protein DUF2203 PF09969.9 ETO23411.1 - 2.6 8.8 11.7 3.7 8.3 3.4 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) ABC_tran_CTD PF16326.5 ETO23411.1 - 3 8.1 13.7 6.3 7.1 0.8 3.4 2 1 1 3 3 3 0 ABC transporter C-terminal domain DivIC PF04977.15 ETO23411.1 - 3.5 7.4 22.6 0.81 9.5 1.4 3.8 2 1 2 4 4 4 0 Septum formation initiator DUF4446 PF14584.6 ETO23411.1 - 3.6 7.6 13.0 0.37 10.8 2.8 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF4446) XhlA PF10779.9 ETO23411.1 - 4.3 7.6 20.6 0.76 10.0 1.6 3.3 2 1 2 4 4 3 0 Haemolysin XhlA BST2 PF16716.5 ETO23411.1 - 4.6 7.9 17.1 4.5 7.9 5.8 2.6 1 1 2 3 3 3 0 Bone marrow stromal antigen 2 CC2-LZ PF16516.5 ETO23411.1 - 4.7 7.6 16.9 0.86 10.0 1.8 3.5 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF3552 PF12072.8 ETO23411.1 - 4.7 6.6 23.3 0.18 11.2 9.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) Prefoldin_2 PF01920.20 ETO23411.1 - 4.8 7.2 23.9 1.3 9.0 1.5 3.6 2 1 2 4 4 3 0 Prefoldin subunit CENP-H PF05837.12 ETO23411.1 - 4.9 7.6 20.1 5.5 7.4 10.3 2.9 1 1 1 2 2 2 0 Centromere protein H (CENP-H) Swi5 PF07061.11 ETO23411.1 - 4.9 7.3 14.4 9.3 6.4 0.8 3.5 1 1 1 2 2 2 0 Swi5 DUF1664 PF07889.12 ETO23411.1 - 5.4 7.1 11.0 7 6.7 2.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 ETO23411.1 - 5.4 4.8 10.5 8.4 4.2 10.5 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec2p PF06428.11 ETO23411.1 - 5.5 7.0 17.6 3 7.9 1.8 3.4 1 1 2 3 3 3 0 GDP/GTP exchange factor Sec2p Mto2_bdg PF12808.7 ETO23411.1 - 5.6 7.3 19.8 0.15 12.3 1.3 4.4 2 1 1 3 3 2 0 Micro-tubular organiser Mto1 C-term Mto2-binding region DHR10 PF18595.1 ETO23411.1 - 6.1 6.9 23.6 0.89 9.6 6.3 3.1 1 1 3 4 4 4 0 Designed helical repeat protein 10 domain TolA_bind_tri PF16331.5 ETO23411.1 - 7.4 6.7 19.2 0.88 9.7 0.2 3.5 2 1 1 3 3 3 0 TolA binding protein trimerisation WWE PF02825.20 ETO23413.1 - 5.3e-07 30.1 0.1 1e-06 29.2 0.1 1.5 1 0 0 1 1 1 1 WWE domain Pkinase PF00069.25 ETO23414.1 - 6.5e-15 55.2 0.0 1.1e-14 54.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain EF-hand_7 PF13499.6 ETO23414.1 - 1.8e-14 53.9 5.7 2.7e-11 43.7 3.8 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO23414.1 - 1.8e-13 49.0 12.7 2.4e-08 32.9 1.0 3.4 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ETO23414.1 - 2e-11 42.9 10.7 0.00022 20.9 0.5 3.4 3 0 0 3 3 3 3 EF-hand domain EF-hand_5 PF13202.6 ETO23414.1 - 2.9e-09 36.0 14.8 1.7e-05 24.1 1.0 3.4 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO23414.1 - 4e-07 29.8 9.1 2.9e-05 23.8 3.3 3.6 2 2 1 3 3 3 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO23414.1 - 1.5e-05 25.3 3.2 0.00048 20.4 0.3 2.3 1 1 1 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO23414.1 - 4.4e-05 23.4 3.3 0.00025 20.9 0.5 2.4 2 0 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand Pkinase_Tyr PF07714.17 ETO23414.1 - 0.00026 20.3 0.0 0.0005 19.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase OSR1_C PF12202.8 ETO23414.1 - 0.01 16.0 1.6 0.048 13.9 1.6 2.1 1 1 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Dockerin_1 PF00404.18 ETO23414.1 - 0.022 14.9 6.3 0.053 13.7 1.9 3.1 2 1 1 3 3 3 0 Dockerin type I domain RasGEF_N PF00618.20 ETO23415.1 - 8.4e-06 26.0 0.1 3.6e-05 23.9 0.1 2.1 1 0 0 1 1 1 1 RasGEF N-terminal motif Polysacc_deac_1 PF01522.21 ETO23416.1 - 0.0015 18.5 0.3 0.0023 17.8 0.3 1.4 1 1 0 1 1 1 1 Polysaccharide deacetylase partial_CstF PF15861.5 ETO23416.1 - 0.063 13.1 0.3 0.1 12.4 0.3 1.3 1 0 0 1 1 1 0 Partial cleavage stimulation factor domain LAP1C PF05609.12 ETO23416.1 - 0.44 9.6 12.1 0.52 9.4 12.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) HSA PF07529.13 ETO23416.1 - 0.76 10.1 10.7 0.12 12.7 1.7 2.4 2 0 0 2 2 2 0 HSA Macoilin PF09726.9 ETO23416.1 - 1.8 7.0 13.9 2.2 6.7 13.9 1.0 1 0 0 1 1 1 0 Macoilin family KASH_CCD PF14662.6 ETO23417.1 - 0.00042 20.2 14.5 0.00062 19.6 14.5 1.3 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH Cep57_CLD_2 PF14197.6 ETO23417.1 - 0.00068 19.7 9.3 0.076 13.1 0.8 2.6 2 0 0 2 2 2 2 Centrosome localisation domain of PPC89 ATG16 PF08614.11 ETO23417.1 - 0.003 17.8 12.6 0.1 12.8 12.6 2.3 1 1 0 1 1 1 1 Autophagy protein 16 (ATG16) ZapB PF06005.12 ETO23417.1 - 0.0035 17.7 12.5 0.13 12.8 2.1 2.5 2 0 0 2 2 2 2 Cell division protein ZapB GAS PF13851.6 ETO23417.1 - 0.0036 16.7 14.6 0.0053 16.1 14.6 1.2 1 0 0 1 1 1 1 Growth-arrest specific micro-tubule binding SLIDE PF09111.10 ETO23417.1 - 0.0088 16.1 5.0 0.011 15.8 4.3 1.5 1 1 0 1 1 1 1 SLIDE Atg14 PF10186.9 ETO23417.1 - 0.031 13.4 8.0 0.063 12.4 8.0 1.5 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 ETO23417.1 - 0.05 14.2 15.8 0.058 14.0 4.8 2.6 1 1 1 2 2 2 0 Initiation control protein YabA BRE1 PF08647.11 ETO23417.1 - 0.073 13.1 14.8 0.19 11.8 4.5 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase FapA PF03961.13 ETO23417.1 - 0.16 10.5 6.2 0.22 10.1 6.2 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A CENP-F_leu_zip PF10473.9 ETO23417.1 - 0.23 11.5 20.0 0.28 11.2 18.1 1.9 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 OmpH PF03938.14 ETO23417.1 - 0.25 11.7 8.1 0.38 11.1 8.0 1.4 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) LMBR1 PF04791.16 ETO23417.1 - 0.29 10.0 4.7 0.35 9.7 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DivIC PF04977.15 ETO23417.1 - 0.39 10.5 7.4 1 9.1 1.9 2.4 1 1 1 2 2 2 0 Septum formation initiator bZIP_1 PF00170.21 ETO23417.1 - 3.6 7.8 14.1 1 9.5 2.6 2.8 2 1 0 2 2 2 0 bZIP transcription factor Nup54 PF13874.6 ETO23417.1 - 6.2 6.9 8.2 1e+02 3.0 8.2 2.2 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 CDC45 PF02724.14 ETO23418.1 - 0.041 12.2 41.8 0.054 11.8 41.8 1.2 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO23418.1 - 0.22 10.9 53.1 0.26 10.7 53.1 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO23418.1 - 0.43 8.7 47.4 0.54 8.4 47.4 1.1 1 0 0 1 1 1 0 Nop14-like family IPT PF01745.16 ETO23419.1 - 0.071 12.5 0.1 0.098 12.0 0.1 1.2 1 0 0 1 1 1 0 Isopentenyl transferase GerPC PF10737.9 ETO23419.1 - 0.093 12.8 0.0 0.14 12.2 0.0 1.4 1 1 0 1 1 1 0 Spore germination protein GerPC CiPC PF15800.5 ETO23421.1 - 0.0072 16.1 0.4 0.0078 16.0 0.4 1.1 1 0 0 1 1 1 1 Clock interacting protein circadian Cwf_Cwc_15 PF04889.12 ETO23421.1 - 0.66 9.7 17.8 0.04 13.7 11.2 1.8 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Pyrophosphatase PF00719.19 ETO23426.1 - 4.3e-30 104.6 0.3 1.3e-29 103.0 0.3 1.7 1 1 0 1 1 1 1 Inorganic pyrophosphatase mRNA_cap_C PF03919.15 ETO23426.1 - 0.39 11.4 2.8 10 6.8 0.5 3.0 2 1 1 3 3 3 0 mRNA capping enzyme, C-terminal domain VASt PF16016.5 ETO23427.1 - 7.1e-09 36.2 0.1 7.1e-09 36.2 0.1 2.9 3 0 0 3 3 3 1 VAD1 Analog of StAR-related lipid transfer domain Vac7 PF12751.7 ETO23428.1 - 0.1 12.0 0.2 0.15 11.4 0.2 1.2 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 TssO PF17561.2 ETO23430.1 - 0.0092 16.1 2.4 0.024 14.7 2.4 1.8 1 0 0 1 1 1 1 Type VI secretion system, TssO DUF4834 PF16118.5 ETO23430.1 - 0.25 12.3 2.2 0.27 12.2 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Pkinase PF00069.25 ETO23431.1 - 1.5e-34 119.6 0.1 2.7e-34 118.8 0.1 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23431.1 - 4.5e-13 49.1 0.0 7.1e-13 48.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO23431.1 - 6.9e-05 22.3 0.0 0.00013 21.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO23431.1 - 0.028 14.0 0.0 0.1 12.2 0.0 1.9 2 0 0 2 2 2 0 Choline/ethanolamine kinase APH PF01636.23 ETO23431.1 - 0.029 14.3 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO23431.1 - 0.047 13.0 0.0 0.46 9.8 0.0 2.2 1 1 0 2 2 2 0 Kinase-like EF-hand_1 PF00036.32 ETO23432.1 - 5.3e-28 94.4 10.8 1e-07 31.0 0.8 4.4 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO23432.1 - 1.7e-26 92.5 7.6 1e-13 51.5 1.5 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO23432.1 - 1.6e-24 84.3 9.7 1.7e-06 27.3 0.1 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO23432.1 - 4.5e-24 82.3 7.5 1.3e-05 24.7 0.0 4.4 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ETO23432.1 - 1.3e-20 72.9 9.2 8.6e-10 38.3 0.2 4.3 1 1 3 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ETO23432.1 - 4.5e-09 36.5 0.4 7.6e-06 26.2 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO23432.1 - 2.5e-08 34.2 3.2 0.0013 19.0 0.3 3.2 1 1 2 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region Pkinase PF00069.25 ETO23432.1 - 4.2e-07 29.6 0.0 1e-06 28.3 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain EF-hand_4 PF12763.7 ETO23432.1 - 4.9e-06 26.4 6.3 0.09 12.7 0.2 3.2 1 1 2 3 3 3 3 Cytoskeletal-regulatory complex EF hand TerB PF05099.13 ETO23432.1 - 5.4e-06 26.4 3.6 0.00075 19.5 0.4 2.9 2 1 0 2 2 2 2 Tellurite resistance protein TerB EF-hand_10 PF14788.6 ETO23432.1 - 0.00012 21.9 5.2 0.05 13.5 0.5 3.2 2 1 1 3 3 3 2 EF hand EF-hand_11 PF08976.11 ETO23432.1 - 0.00048 21.0 0.9 0.37 11.7 0.1 2.4 1 1 1 2 2 2 2 EF-hand domain MecA_N PF05223.11 ETO23432.1 - 0.0096 16.2 0.5 0.024 14.9 0.2 1.8 2 0 0 2 2 2 1 NTF2-like N-terminal transpeptidase domain SurA_N_3 PF13624.6 ETO23432.1 - 0.012 15.4 2.3 4.5 7.0 0.1 3.3 1 1 3 4 4 4 0 SurA N-terminal domain GFP PF01353.22 ETO23432.1 - 0.027 14.0 0.1 0.095 12.2 0.1 1.8 2 0 0 2 2 2 0 Green fluorescent protein PheRS_DBD3 PF18553.1 ETO23432.1 - 0.16 12.3 0.0 0.69 10.3 0.0 2.0 2 0 0 2 2 2 0 PheRS DNA binding domain 3 DUF3213 PF11491.8 ETO23432.1 - 0.25 11.5 1.8 4.2 7.6 0.7 2.5 1 1 0 2 2 2 0 Protein of unknown function (DUF3213) DUF3361 PF11841.8 ETO23433.1 - 0.00048 20.1 0.9 0.00074 19.5 0.6 1.5 2 0 0 2 2 2 1 Domain of unknown function (DUF3361) Adaptin_N PF01602.20 ETO23433.1 - 0.0025 16.5 0.4 0.0037 15.9 0.4 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Arm PF00514.23 ETO23433.1 - 0.0094 16.0 0.0 0.66 10.1 0.0 2.6 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat LRR_4 PF12799.7 ETO23434.1 - 0.32 11.5 3.9 5.1 7.7 0.6 4.0 4 1 0 4 4 4 0 Leucine Rich repeats (2 copies) 7TM_GPCR_Sra PF02117.16 ETO23435.1 - 0.012 14.4 1.4 0.019 13.8 1.4 1.2 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Sra RBR PF17208.3 ETO23435.1 - 0.018 15.7 4.6 0.06 14.1 4.6 1.9 1 0 0 1 1 1 0 RNA binding Region AT_hook PF02178.19 ETO23435.1 - 2.6 8.2 8.1 8.1 6.7 8.1 1.9 1 0 0 1 1 1 0 AT hook motif Ras PF00071.22 ETO23437.1 - 7.5e-08 32.1 0.1 1.1e-07 31.6 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO23437.1 - 1.6e-07 31.5 0.1 2.8e-07 30.8 0.1 1.6 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 ETO23437.1 - 0.059 12.8 0.0 0.083 12.3 0.0 1.2 1 0 0 1 1 1 0 Bacterial TniB protein WD40 PF00400.32 ETO23438.1 - 1.5e-31 107.9 16.4 3.2e-06 27.8 0.5 6.9 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23438.1 - 4.6e-11 42.9 0.5 0.23 11.8 0.0 5.2 3 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23438.1 - 1.1e-09 37.5 1.9 0.0064 15.2 0.1 4.3 2 1 2 4 4 4 4 Nucleoporin Nup120/160 NCD3G PF07562.14 ETO23438.1 - 0.076 13.0 1.0 0.31 11.0 1.0 2.0 1 0 0 1 1 1 0 Nine Cysteines Domain of family 3 GPCR WD40 PF00400.32 ETO23439.1 - 2.5e-33 113.6 23.0 3e-08 34.2 0.2 6.4 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23439.1 - 5e-15 55.6 1.5 0.0018 18.5 0.0 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23439.1 - 3.5e-08 32.5 6.6 0.045 12.4 0.0 4.8 1 1 3 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO23439.1 - 0.0024 17.8 1.2 0.062 13.2 0.1 3.0 1 1 4 5 5 5 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO23439.1 - 0.0038 16.6 0.4 0.1 11.9 0.0 2.3 1 1 0 2 2 2 1 WD40-like domain Ge1_WD40 PF16529.5 ETO23439.1 - 0.0079 15.2 3.9 1 8.2 0.8 4.0 1 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Mucin PF01456.17 ETO23440.1 - 0.23 11.5 2.4 0.28 11.2 2.4 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein NPR3 PF03666.13 ETO23440.1 - 2.1 7.1 9.1 2.5 6.8 9.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CTP_transf_like PF01467.26 ETO23441.1 - 3.4e-23 82.4 0.0 7.9e-23 81.2 0.0 1.6 1 0 0 1 1 1 1 Cytidylyltransferase-like GRDP-like PF07173.12 ETO23441.1 - 0.065 13.9 0.1 1.5 9.5 0.0 2.3 2 0 0 2 2 2 0 Glycine-rich domain-containing protein-like WD40 PF00400.32 ETO23442.1 - 7.1e-63 207.1 27.2 5.2e-11 42.9 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23442.1 - 1.8e-21 76.2 1.0 0.0011 19.2 0.0 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23442.1 - 1.5e-16 60.3 1.1 0.0015 17.6 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO23442.1 - 4e-10 39.0 5.6 0.05 12.3 0.0 5.2 2 2 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO23442.1 - 4.7e-08 32.7 0.3 0.04 13.2 0.0 3.4 1 1 1 3 3 3 3 WD40-like domain Nbas_N PF15492.6 ETO23442.1 - 2.7e-05 23.7 1.1 0.18 11.1 0.0 3.7 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO23442.1 - 5.9e-05 21.8 1.0 2.5 6.5 0.0 3.6 1 1 4 5 5 5 4 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO23442.1 - 0.0001 22.4 3.6 11 6.1 0.0 4.4 1 1 4 5 5 5 0 Family of unknown function (DUF5570) PALB2_WD40 PF16756.5 ETO23442.1 - 0.0009 18.3 2.2 3.9 6.3 0.0 4.3 2 2 3 5 5 5 1 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO23442.1 - 0.0013 18.6 9.0 3.6 7.6 0.1 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO23442.1 - 0.0059 16.2 0.5 23 4.7 0.0 4.3 5 0 0 5 5 5 0 HepA-related protein (HARP) SGL PF08450.12 ETO23442.1 - 0.0064 16.1 0.4 0.4 10.2 0.2 2.7 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Me-amine-dh_H PF06433.11 ETO23442.1 - 0.016 14.1 0.0 8.7 5.1 0.0 3.1 2 1 1 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) DUF4988 PF16378.5 ETO23442.1 - 0.025 14.3 0.0 32 4.1 0.0 3.4 3 1 0 3 3 3 0 Domain of unknown function SoxZ PF08770.11 ETO23442.1 - 0.025 14.4 0.0 25 4.7 0.0 3.2 3 0 0 3 3 3 0 Sulphur oxidation protein SoxZ TruB_C PF09142.11 ETO23442.1 - 0.21 11.4 0.0 10 6.0 0.0 2.6 2 0 0 2 2 2 0 tRNA Pseudouridine synthase II, C terminal Proteasome_A_N PF10584.9 ETO23442.1 - 3 7.6 10.9 30 4.4 0.0 5.2 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature 7tm_3 PF00003.22 ETO23444.1 - 1.3e-32 113.4 30.5 1.3e-32 113.4 30.5 3.0 3 0 0 3 3 3 1 7 transmembrane sweet-taste receptor of 3 GCPR XK-related PF09815.9 ETO23448.1 - 0.0002 20.6 10.0 0.00051 19.2 10.0 1.6 1 1 0 1 1 1 1 XK-related protein DUF3007 PF11460.8 ETO23448.1 - 0.059 13.6 0.2 0.092 13.0 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3007) PALP PF00291.25 ETO23453.1 - 3.6e-53 180.9 0.0 4.6e-53 180.5 0.0 1.1 1 0 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme CBS PF00571.28 ETO23453.1 - 1.2e-09 38.4 0.2 0.007 16.8 0.1 3.8 3 0 0 3 3 3 3 CBS domain zinc_ribbon_13 PF09855.9 ETO23453.1 - 0.047 13.9 0.0 0.12 12.6 0.0 1.6 1 0 0 1 1 1 0 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082) RabGAP-TBC PF00566.18 ETO23454.1 - 6.8e-28 97.8 20.3 3.6e-26 92.2 20.2 3.0 1 1 0 1 1 1 1 Rab-GTPase-TBC domain Vfa1 PF08432.10 ETO23454.1 - 0.0036 17.7 5.8 0.0086 16.4 5.8 1.6 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 PRIMA1 PF16101.5 ETO23454.1 - 0.0042 17.1 3.5 0.0089 16.1 3.5 1.5 1 0 0 1 1 1 1 Proline-rich membrane anchor 1 TIP120 PF08623.10 ETO23454.1 - 0.0082 15.9 0.1 0.018 14.8 0.1 1.6 1 0 0 1 1 1 1 TATA-binding protein interacting (TIP20) Connexin PF00029.19 ETO23454.1 - 0.018 14.8 4.0 0.032 14.0 1.8 2.4 2 0 0 2 2 2 0 Connexin Pex14_N PF04695.13 ETO23454.1 - 0.26 12.0 3.1 0.94 10.1 0.5 2.8 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFB6 PF17110.5 ETO23454.1 - 0.51 10.1 5.1 1.2 8.8 5.1 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CAP_N PF01213.19 ETO23454.1 - 1.2 8.6 7.1 2.9 7.3 7.1 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal CDC45 PF02724.14 ETO23454.1 - 5.4 5.2 11.2 9.6 4.4 11.2 1.3 1 0 0 1 1 1 0 CDC45-like protein EF-hand_1 PF00036.32 ETO23455.1 - 2.2e-10 39.3 2.2 6.4e-06 25.4 0.1 2.4 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO23455.1 - 1.6e-09 36.9 0.1 2.5e-05 23.8 0.0 2.5 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO23455.1 - 6.1e-08 33.0 3.2 1.3e-07 31.9 3.2 1.6 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO23455.1 - 1.8e-07 30.3 1.0 3.7e-06 26.2 0.2 2.6 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO23455.1 - 0.00014 21.7 0.3 0.0025 17.6 0.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair Skp1 PF01466.19 ETO23456.1 - 3.5e-26 91.1 0.2 3.5e-26 91.1 0.2 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETO23456.1 - 9.7e-11 41.7 0.3 5.3e-06 26.5 0.0 2.4 1 1 0 2 2 2 2 Skp1 family, tetramerisation domain DNA_pol_B_3 PF08408.10 ETO23456.1 - 0.043 14.0 0.4 0.085 13.1 0.4 1.5 1 0 0 1 1 1 0 DNA polymerase family B viral insert Csm2_III-A PF03750.13 ETO23456.1 - 0.088 13.6 4.0 2.4 9.0 1.6 2.7 2 1 1 3 3 3 0 Csm2 Type III-A Myb_DNA-binding PF00249.31 ETO23456.1 - 0.09 13.0 0.1 2.1 8.6 0.0 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain BTB PF00651.31 ETO23456.1 - 0.14 12.4 1.0 1.1 9.6 0.2 2.4 1 1 0 2 2 2 0 BTB/POZ domain BBS1 PF14779.6 ETO23457.1 - 1e-20 74.3 2.4 4.2e-20 72.3 0.1 2.4 3 0 0 3 3 3 1 Ciliary BBSome complex subunit 1 CNOT11 PF10155.9 ETO23457.1 - 0.0068 16.6 2.1 0.012 15.7 2.1 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 11 CBM9_2 PF16011.5 ETO23459.1 - 6.8e-11 42.2 2.1 8.4e-11 41.9 2.1 1.1 1 0 0 1 1 1 1 Carbohydrate-binding family 9 CBM9_1 PF06452.11 ETO23459.1 - 0.04 13.8 0.2 0.065 13.1 0.2 1.6 1 1 0 1 1 1 0 Carbohydrate family 9 binding domain-like PXA PF02194.15 ETO23460.1 - 0.00025 21.1 0.5 0.0057 16.7 0.5 2.3 1 1 0 1 1 1 1 PXA domain HEAT_2 PF13646.6 ETO23460.1 - 0.00095 19.5 0.1 0.0032 17.8 0.1 1.8 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO23460.1 - 0.0025 18.0 0.2 0.49 10.8 0.0 2.6 2 0 0 2 2 2 1 HEAT repeat Cohesin_HEAT PF12765.7 ETO23460.1 - 0.14 12.5 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 HEAT repeat associated with sister chromatid cohesion MRPL52 PF18699.1 ETO23460.1 - 0.43 10.8 3.1 3.4 7.9 0.1 2.6 2 0 0 2 2 2 0 Mitoribosomal protein mL52 BLOC1_2 PF10046.9 ETO23462.1 - 0.00044 20.5 6.7 0.00044 20.5 6.7 2.1 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 CCDC-167 PF15188.6 ETO23462.1 - 0.0072 16.6 7.5 3.5 8.0 0.0 2.2 2 0 0 2 2 2 2 Coiled-coil domain-containing protein 167 GAS PF13851.6 ETO23462.1 - 0.0091 15.4 17.3 0.0091 15.4 17.3 2.0 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Lebercilin PF15619.6 ETO23462.1 - 0.01 15.5 15.8 0.01 15.5 15.8 2.0 1 1 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease Glyco_tran_WecB PF03808.13 ETO23462.1 - 0.013 15.5 0.4 0.036 14.0 0.4 1.8 1 1 0 1 1 1 0 Glycosyl transferase WecB/TagA/CpsF family DASH_Dam1 PF08653.10 ETO23462.1 - 0.2 11.5 1.9 3.2 7.6 0.2 2.7 2 1 1 3 3 3 0 DASH complex subunit Dam1 MitMem_reg PF13012.6 ETO23462.1 - 0.31 11.5 4.4 0.75 10.2 4.4 1.5 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function V_ATPase_I PF01496.19 ETO23462.1 - 0.78 7.6 8.9 0.89 7.4 8.9 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FliD_N PF02465.18 ETO23462.1 - 1.3 9.7 17.7 4 8.2 9.8 2.1 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus IPK PF03770.16 ETO23462.1 - 1.4 8.7 10.7 1.9 8.3 10.7 1.1 1 0 0 1 1 1 0 Inositol polyphosphate kinase DUF4061 PF13270.6 ETO23462.1 - 1.4 9.3 8.8 3.7 7.9 0.5 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4061) DUF3450 PF11932.8 ETO23462.1 - 1.8 7.8 12.4 3.2 7.0 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) ATG16 PF08614.11 ETO23462.1 - 2.2 8.5 18.8 0.34 11.1 13.2 1.9 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) FUSC-like PF12805.7 ETO23462.1 - 2.4 7.2 6.2 7.4 5.6 2.8 2.0 1 1 1 2 2 2 0 FUSC-like inner membrane protein yccS Cep57_MT_bd PF06657.13 ETO23462.1 - 2.8 8.5 14.7 1.1 9.7 0.4 3.0 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Exonuc_VII_L PF02601.15 ETO23462.1 - 3.8 7.0 10.8 4.6 6.7 10.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4094 PF13334.6 ETO23462.1 - 9.1 6.8 12.6 3.1 8.3 9.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Atg14 PF10186.9 ETO23462.1 - 9.5 5.2 21.7 18 4.3 21.7 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HSP70 PF00012.20 ETO23463.1 - 0.001 17.3 1.6 0.002 16.4 1.7 1.4 1 1 0 1 1 1 1 Hsp70 protein CorA PF01544.18 ETO23464.1 - 1.1e-32 113.5 0.1 1.1e-32 113.5 0.1 1.5 2 0 0 2 2 2 1 CorA-like Mg2+ transporter protein eIF-3c_N PF05470.12 ETO23464.1 - 0.051 11.9 4.7 0.079 11.3 4.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PSII PF00421.19 ETO23464.1 - 0.12 11.0 0.3 0.18 10.4 0.3 1.1 1 0 0 1 1 1 0 Photosystem II protein CDC45 PF02724.14 ETO23464.1 - 0.86 7.8 4.2 1.1 7.4 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 ETO23464.1 - 1.9 7.8 8.3 3.2 7.1 8.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) NOA36 PF06524.12 ETO23464.1 - 5.6 6.2 10.0 10 5.4 10.0 1.3 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO23464.1 - 5.9 4.9 9.9 9.1 4.2 9.9 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF1491 PF07372.12 ETO23468.1 - 0.072 13.5 0.0 0.12 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1491) Actin PF00022.19 ETO23469.1 - 6.3e-79 265.5 0.0 8.5e-79 265.1 0.0 1.1 1 0 0 1 1 1 1 Actin G6PD_C PF02781.16 ETO23471.1 - 5.8e-93 311.2 0.0 4.9e-92 308.2 0.0 1.9 1 1 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ETO23471.1 - 9.3e-32 111.1 0.4 1.5e-31 110.4 0.4 1.3 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain DUF4460 PF14687.6 ETO23471.1 - 0.017 15.2 1.5 0.2 11.7 1.1 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4460) E2_bind PF08825.10 ETO23471.1 - 0.082 13.1 0.8 0.34 11.1 0.8 2.0 1 0 0 1 1 1 0 E2 binding domain SH PF01445.17 ETO23471.1 - 0.31 11.0 2.6 0.87 9.6 2.6 1.7 1 0 0 1 1 1 0 Viral small hydrophobic protein MFS_1_like PF12832.7 ETO23472.1 - 1.6e-55 188.5 10.0 2.2e-55 188.1 10.0 1.2 1 0 0 1 1 1 1 MFS_1 like family MFS_1 PF07690.16 ETO23472.1 - 1.4e-15 57.1 38.8 1.3e-09 37.5 20.1 3.4 3 1 1 4 4 4 3 Major Facilitator Superfamily Nuc_H_symport PF03825.16 ETO23472.1 - 4.6e-07 29.2 10.4 4.6e-07 29.2 10.4 2.1 2 0 0 2 2 2 1 Nucleoside H+ symporter WD40 PF00400.32 ETO23473.1 - 1.2e-17 63.9 12.7 9.6e-06 26.3 0.0 5.3 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO23473.1 - 1.6e-06 27.1 1.1 0.054 12.1 0.0 3.6 2 1 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO23473.1 - 0.0033 17.7 0.8 8.3 6.8 0.0 3.6 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO23473.1 - 0.036 12.8 1.3 3.5 6.3 0.0 2.7 2 1 0 2 2 2 0 Nup133 N terminal like Ole-e-6 PF09253.10 ETO23473.1 - 0.042 13.8 2.1 0.079 12.9 2.1 1.4 1 0 0 1 1 1 0 Pollen allergen ole e 6 His_kinase PF06580.13 ETO23475.1 - 0.027 14.8 0.5 4.6 7.6 0.6 3.2 2 1 0 2 2 2 0 Histidine kinase TACC_C PF05010.14 ETO23475.1 - 0.38 10.5 9.1 0.17 11.7 3.8 2.6 2 1 1 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal PCRF PF03462.18 ETO23475.1 - 1.1 9.1 3.8 0.39 10.5 0.8 1.8 2 0 0 2 2 2 0 PCRF domain TFIIA PF03153.13 ETO23476.1 - 0.08 12.9 28.9 2.9 7.8 24.4 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CRAL_TRIO PF00650.20 ETO23476.1 - 0.14 11.9 4.8 12 5.6 0.0 3.2 3 0 0 3 3 3 0 CRAL/TRIO domain SapB_2 PF03489.17 ETO23476.1 - 0.77 9.9 3.1 0.61 10.2 0.2 2.2 2 0 0 2 2 2 0 Saposin-like type B, region 2 Cation_ATPase PF13246.6 ETO23477.1 - 3.2e-12 46.3 0.4 3.9e-11 42.9 0.2 2.5 2 1 0 2 2 2 1 Cation transport ATPase (P-type) PhoLip_ATPase_C PF16212.5 ETO23477.1 - 1.2e-10 41.6 0.0 2.1e-10 40.8 0.0 1.3 1 0 0 1 1 1 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 ETO23477.1 - 1.2e-09 38.8 0.1 0.0014 19.0 0.0 2.4 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase SDA1 PF05285.12 ETO23477.1 - 0.0011 18.5 16.5 0.0011 18.5 16.5 1.6 2 0 0 2 2 2 1 SDA1 Hydrolase_3 PF08282.12 ETO23477.1 - 0.0018 18.1 0.9 0.0018 18.1 0.9 3.3 2 2 1 3 3 3 1 haloacid dehalogenase-like hydrolase Nop14 PF04147.12 ETO23477.1 - 4.6 5.3 22.4 8.4 4.5 22.4 1.3 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO23477.1 - 5.3 6.3 26.2 0.31 10.3 21.3 1.4 2 0 0 2 2 2 0 BUD22 PhoLip_ATPase_C PF16212.5 ETO23478.1 - 3.6e-16 59.7 16.8 3.6e-16 59.7 16.8 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Abhydrolase_9_N PF15420.6 ETO23478.1 - 0.048 13.7 3.5 0.086 12.8 3.5 1.3 1 0 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus DUF4175 PF13779.6 ETO23478.1 - 0.069 11.1 1.6 0.1 10.5 1.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4175) Bac_export_2 PF01312.19 ETO23478.1 - 0.32 10.1 5.3 0.94 8.6 5.1 1.7 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family DUF382 PF04037.13 ETO23479.1 - 2.7 8.2 6.9 6.6 6.9 0.8 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF382) PTPlike_phytase PF14566.6 ETO23479.1 - 3.2 7.8 13.5 1.3 9.1 3.4 3.1 2 1 1 3 3 3 0 Inositol hexakisphosphate FKS1_dom1 PF14288.6 ETO23481.1 - 1.3 9.4 5.5 10 6.4 0.0 3.8 2 1 1 3 3 3 0 1,3-beta-glucan synthase subunit FKS1, domain-1 Aph-1 PF06105.12 ETO23485.1 - 0.036 13.5 0.2 0.057 12.8 0.2 1.2 1 0 0 1 1 1 0 Aph-1 protein Ank_4 PF13637.6 ETO23486.1 - 2.4e-18 66.2 0.2 4.2e-10 40.0 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO23486.1 - 9e-17 61.4 0.3 5.1e-12 46.2 0.1 3.1 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO23486.1 - 1.5e-15 56.8 0.1 0.01 16.2 0.0 5.0 5 0 0 5 5 5 4 Ankyrin repeat Ank_3 PF13606.6 ETO23486.1 - 1.4e-12 46.6 0.1 0.036 14.6 0.0 5.1 5 0 0 5 5 5 4 Ankyrin repeat Ank_5 PF13857.6 ETO23486.1 - 1.6e-11 44.2 10.2 5.1e-06 26.7 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) YwiC PF14256.6 ETO23486.1 - 0.31 11.4 2.9 0.51 10.7 2.9 1.3 1 0 0 1 1 1 0 YwiC-like protein O-ag_pol_Wzy PF14296.6 ETO23486.1 - 0.54 8.8 13.0 1 7.9 13.0 1.4 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Zip PF02535.22 ETO23486.1 - 9.3 5.4 6.5 18 4.4 6.5 1.6 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO23486.1 - 9.9 4.4 13.7 14 3.8 13.7 1.2 1 0 0 1 1 1 0 Menin Fungal_trans_2 PF11951.8 ETO23487.1 - 0.15 10.9 3.0 0.42 9.4 0.0 2.0 1 1 1 2 2 2 0 Fungal specific transcription factor domain Methyltransf_11 PF08241.12 ETO23489.1 - 2.3e-07 31.4 0.2 0.0071 17.0 0.0 3.8 3 1 0 3 3 3 2 Methyltransferase domain Methyltransf_25 PF13649.6 ETO23489.1 - 6.8e-06 26.7 0.2 0.009 16.7 0.0 4.0 3 1 0 3 3 3 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO23489.1 - 3.5e-05 24.5 7.4 0.00063 20.5 0.0 3.8 4 0 0 4 4 4 2 Methyltransferase domain Methyltransf_31 PF13847.6 ETO23489.1 - 0.00013 21.8 0.4 0.0084 15.9 0.4 3.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO23489.1 - 0.0014 18.5 0.0 0.0057 16.5 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETO23489.1 - 0.004 16.7 0.2 0.018 14.6 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase small domain Methyltransf_32 PF13679.6 ETO23489.1 - 0.042 13.8 0.0 0.042 13.8 0.0 3.8 3 2 0 3 3 3 0 Methyltransferase domain S_4TM PF18159.1 ETO23490.1 - 1.2 8.3 0.0 1.2 8.3 0.0 3.0 3 0 0 3 3 3 0 SMODS-associating 4TM effector domain DUF2817 PF10994.8 ETO23492.1 - 3.1e-38 132.0 5.3 5.8e-27 95.0 0.0 4.1 2 1 1 3 3 3 3 Protein of unknown function (DUF2817) Methyltransf_20 PF12147.8 ETO23492.1 - 0.061 12.5 0.0 0.1 11.7 0.0 1.2 1 0 0 1 1 1 0 Putative methyltransferase Ras PF00071.22 ETO23493.1 - 2.5e-12 46.7 2.6 1.8e-09 37.4 0.2 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO23493.1 - 9.2e-07 29.1 3.2 5.8e-05 23.3 0.3 2.1 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase DrrA_P4M PF14860.6 ETO23493.1 - 0.026 14.4 0.9 0.047 13.5 0.9 1.4 1 0 0 1 1 1 0 DrrA phosphatidylinositol 4-phosphate binding domain JAB PF01398.21 ETO23496.1 - 3.2e-24 85.2 0.2 3.2e-24 85.2 0.2 1.7 2 0 0 2 2 2 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease MitMem_reg PF13012.6 ETO23496.1 - 2.7e-10 40.7 0.2 5.9e-10 39.6 0.1 1.6 2 0 0 2 2 2 1 Maintenance of mitochondrial structure and function Prok-JAB PF14464.6 ETO23496.1 - 0.00081 19.2 0.0 0.0013 18.5 0.0 1.3 1 0 0 1 1 1 1 Prokaryotic homologs of the JAB domain COX4 PF02936.14 ETO23496.1 - 0.048 13.7 0.2 0.12 12.4 0.2 1.6 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IV NfrA_C PF13283.6 ETO23497.1 - 0.025 14.1 0.0 0.033 13.7 0.0 1.1 1 0 0 1 1 1 0 Bacteriophage N adsorption protein A C-term Secretin_N_2 PF07655.13 ETO23498.1 - 7.3 7.2 13.3 1.8 9.1 9.6 1.8 2 0 0 2 2 2 0 Secretin N-terminal domain ADH_N_2 PF16884.5 ETO23499.1 - 0.0043 16.9 0.0 0.0063 16.4 0.0 1.2 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase PIP5K PF01504.18 ETO23499.1 - 0.037 13.2 0.1 0.046 13.0 0.1 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-4-phosphate 5-Kinase ADH_N PF08240.12 ETO23500.1 - 1.9e-10 40.6 3.1 2.8e-10 40.0 3.1 1.2 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain FerB PF08150.12 ETO23500.1 - 0.19 12.3 0.8 0.86 10.2 0.1 2.1 2 0 0 2 2 2 0 FerB (NUC096) domain E1_UFD PF09358.10 ETO23501.1 - 0.66 10.7 4.7 0.3 11.8 0.6 2.0 2 0 0 2 2 2 0 Ubiquitin fold domain DUF3522 PF12036.8 ETO23502.1 - 4.3e-27 95.6 6.8 4.9e-27 95.4 6.8 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Ceramidase PF05875.12 ETO23502.1 - 6.2 6.2 13.0 57 3.0 13.0 2.1 1 1 0 1 1 1 0 Ceramidase SNARE PF05739.19 ETO23503.1 - 7.2e-08 32.3 0.0 7.2e-08 32.3 0.0 2.3 2 0 0 2 2 2 1 SNARE domain DUF5083 PF16890.5 ETO23503.1 - 0.042 13.6 0.0 0.082 12.6 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5083) Peptidase_C97 PF05903.14 ETO23504.1 - 0.026 14.4 0.1 0.057 13.2 0.1 1.5 1 0 0 1 1 1 0 PPPDE putative peptidase domain Ribosomal_L16 PF00252.18 ETO23504.1 - 0.11 12.4 0.0 0.43 10.6 0.0 1.8 2 0 0 2 2 2 0 Ribosomal protein L16p/L10e EF-hand_7 PF13499.6 ETO23505.1 - 0.00082 19.8 0.0 0.0013 19.2 0.0 1.3 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO23505.1 - 0.0061 16.4 0.2 4 7.6 0.0 2.7 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO23505.1 - 0.013 15.0 0.0 3 7.6 0.0 2.5 2 0 0 2 2 2 0 EF hand Ank_2 PF12796.7 ETO23506.1 - 1.3e-19 70.5 5.3 3e-14 53.4 0.7 3.1 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO23506.1 - 4.5e-17 61.7 4.9 2.6e-05 24.5 0.0 4.8 4 1 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 ETO23506.1 - 1.8e-16 60.3 4.3 0.00038 20.9 0.1 4.4 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO23506.1 - 4.6e-15 54.2 2.2 0.0012 19.2 0.0 4.7 4 0 0 4 4 4 4 Ankyrin repeat Ank_5 PF13857.6 ETO23506.1 - 2.1e-11 43.8 2.1 8.1e-07 29.2 0.3 3.6 2 1 1 3 3 3 3 Ankyrin repeats (many copies) bZIP_1 PF00170.21 ETO23506.1 - 0.01 15.9 0.2 0.01 15.9 0.2 2.7 3 0 0 3 3 3 0 bZIP transcription factor APG6_N PF17675.1 ETO23506.1 - 0.015 15.8 1.4 0.015 15.8 1.4 1.6 2 0 0 2 2 2 0 Apg6 coiled-coil region ZapB PF06005.12 ETO23506.1 - 0.11 12.9 6.4 0.29 11.6 6.4 1.7 1 0 0 1 1 1 0 Cell division protein ZapB YabA PF06156.13 ETO23506.1 - 2.7 8.7 9.2 37 5.0 7.5 2.7 2 1 0 2 2 2 0 Initiation control protein YabA Ank_2 PF12796.7 ETO23507.1 - 4.5e-08 33.6 0.0 0.0026 18.3 0.0 2.3 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO23507.1 - 7.1e-06 26.5 0.0 0.08 13.6 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO23507.1 - 9.2e-06 25.8 0.1 0.082 13.3 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO23507.1 - 0.00041 20.6 0.7 0.8 10.5 0.0 3.7 3 1 1 4 4 4 1 Ankyrin repeat Ank PF00023.30 ETO23507.1 - 0.016 15.6 0.0 10 6.8 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat MIEAP PF16026.5 ETO23508.1 - 3e-11 43.9 0.5 4.4e-11 43.4 0.5 1.2 1 0 0 1 1 1 1 Mitochondria-eating protein RhoGEF PF00621.20 ETO23510.1 - 1.3e-42 146.1 5.9 1.7e-42 145.7 5.9 1.2 1 0 0 1 1 1 1 RhoGEF domain Ferritin PF00210.24 ETO23510.1 - 0.084 12.8 0.3 4 7.4 0.0 2.2 2 0 0 2 2 2 0 Ferritin-like domain Menin PF05053.13 ETO23510.1 - 0.97 7.7 5.0 1.4 7.2 5.0 1.2 1 0 0 1 1 1 0 Menin BTV_NS2 PF04514.12 ETO23511.1 - 0.018 13.9 0.0 0.046 12.6 0.0 1.6 2 0 0 2 2 2 0 Bluetongue virus non-structural protein NS2 SprA-related PF12118.8 ETO23511.1 - 1.5 7.9 5.4 2.8 7.0 5.4 1.3 1 0 0 1 1 1 0 SprA-related family Presenilin PF01080.17 ETO23512.1 - 0.015 14.1 5.7 0.02 13.6 5.7 1.2 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO23512.1 - 0.081 11.3 13.4 0.1 10.9 13.4 1.1 1 0 0 1 1 1 0 Menin CPSF100_C PF13299.6 ETO23512.1 - 0.084 13.1 5.0 0.18 12.0 5.0 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 ETO23512.1 - 0.1 11.8 2.5 0.11 11.7 2.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter POX PF07526.11 ETO23512.1 - 0.66 10.6 5.1 1.4 9.5 5.1 1.5 1 0 0 1 1 1 0 Associated with HOX Gti1_Pac2 PF09729.9 ETO23512.1 - 2.7 8.1 15.1 0.31 11.1 10.8 1.6 2 0 0 2 2 2 0 Gti1/Pac2 family Striatin PF08232.12 ETO23512.1 - 3.1 8.4 10.2 0.53 10.9 6.0 1.9 2 0 0 2 2 2 0 Striatin family NRIP1_repr_1 PF15687.5 ETO23512.1 - 3.4 7.3 9.9 6.4 6.3 9.9 1.4 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 1 DUF2076 PF09849.9 ETO23512.1 - 7.6 6.5 18.2 11 6.0 18.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) NOA36 PF06524.12 ETO23512.1 - 8.8 5.5 13.0 14 4.9 13.0 1.2 1 0 0 1 1 1 0 NOA36 protein WD40 PF00400.32 ETO23513.1 - 2.9e-10 40.6 1.4 0.026 15.4 0.1 4.6 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23513.1 - 0.00038 20.7 0.0 0.058 13.7 0.0 2.6 1 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain ASH PF15780.5 ETO23513.1 - 0.01 16.0 0.0 0.023 14.9 0.0 1.5 1 0 0 1 1 1 0 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin TPR_12 PF13424.6 ETO23515.1 - 2.5e-98 322.4 46.0 3.1e-15 56.2 0.1 10.6 6 3 8 14 14 13 13 Tetratricopeptide repeat TPR_10 PF13374.6 ETO23515.1 - 8.2e-74 241.7 5.9 4.4e-07 29.6 0.0 15.9 16 0 0 16 16 16 12 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23515.1 - 4.4e-50 163.8 51.3 5.7e-05 22.9 0.0 16.3 16 0 0 16 16 16 12 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23515.1 - 4.9e-48 157.7 33.2 9.3e-06 25.3 0.1 15.6 16 0 0 16 16 15 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23515.1 - 8.2e-47 155.2 54.4 8.6e-08 31.7 0.0 15.6 16 0 0 16 16 15 12 Tetratricopeptide repeat TPR_14 PF13428.6 ETO23515.1 - 1.1e-14 53.8 9.9 0.38 11.7 0.0 12.2 11 3 3 14 14 12 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23515.1 - 9.7e-14 50.4 39.1 0.00036 20.5 0.1 11.9 12 0 0 12 12 11 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO23515.1 - 4.8e-12 45.4 12.8 0.054 13.9 0.0 10.4 11 0 0 11 11 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO23515.1 - 3.3e-10 39.9 28.6 0.45 11.3 0.0 13.4 15 0 0 15 15 14 2 Tetratricopeptide repeat PPR PF01535.20 ETO23515.1 - 1.2e-09 37.8 9.2 1.5 9.3 0.0 9.2 11 0 0 11 11 10 2 PPR repeat TPR_16 PF13432.6 ETO23515.1 - 1.3e-07 32.2 8.6 0.005 17.5 0.0 8.0 9 1 1 10 10 7 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO23515.1 - 3.3e-06 26.7 45.8 0.038 13.7 0.0 13.8 14 3 2 16 16 16 3 TPR repeat SPO22 PF08631.10 ETO23515.1 - 1.1e-05 25.1 8.4 0.1 12.1 0.1 5.6 4 2 2 7 7 7 2 Meiosis protein SPO22/ZIP4 like DUF5113 PF17140.4 ETO23515.1 - 2.6e-05 24.1 27.1 2.5 7.9 0.0 10.3 10 3 2 13 13 13 2 Domain of unknown function (DUF5113) TPR_9 PF13371.6 ETO23515.1 - 2.7e-05 24.2 2.1 2.5 8.3 0.0 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO23515.1 - 6e-05 22.6 4.9 0.0098 15.3 0.0 3.8 2 2 2 4 4 4 1 MalT-like TPR region SAND PF01342.21 ETO23515.1 - 0.00012 21.7 17.2 7.4 6.4 0.5 9.2 9 2 1 10 10 9 0 SAND domain SHNi-TPR PF10516.9 ETO23515.1 - 0.00019 20.8 0.1 1.3 8.5 0.1 4.9 4 0 0 4 4 4 1 SHNi-TPR DUF3856 PF12968.7 ETO23515.1 - 0.012 15.7 7.7 3.2 7.8 0.0 6.4 6 3 1 8 8 8 0 Domain of Unknown Function (DUF3856) Imm70 PF15601.6 ETO23515.1 - 0.017 14.7 0.0 0.04 13.5 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 70 MazG_C PF18722.1 ETO23515.1 - 0.022 14.2 0.8 1.3 8.5 0.0 3.5 3 1 0 3 3 3 0 MazG C-terminal domain Rapsyn_N PF10579.9 ETO23515.1 - 0.076 13.1 2.9 4.7 7.4 0.1 5.0 5 2 2 7 7 6 0 Rapsyn N-terminal myristoylation and linker region TPR_4 PF07721.14 ETO23515.1 - 0.11 13.2 0.0 7 7.6 0.0 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4810 PF16068.5 ETO23515.1 - 0.11 13.1 0.1 1.9 9.1 0.0 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4810) DUF627 PF04781.12 ETO23515.1 - 0.19 11.8 6.1 4.4 7.4 0.0 5.4 6 1 0 6 6 6 0 Protein of unknown function (DUF627) TPR_19 PF14559.6 ETO23515.1 - 0.46 11.0 13.7 4.4 7.9 0.1 7.0 11 1 1 12 12 6 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO23515.1 - 0.55 10.3 11.1 2.2 8.4 0.0 6.1 7 0 0 7 7 7 0 Fis1 C-terminal tetratricopeptide repeat Clathrin PF00637.20 ETO23515.1 - 1.5 8.7 14.9 62 3.5 1.4 6.9 4 3 5 9 9 9 0 Region in Clathrin and VPS Syntaxin_2 PF14523.6 ETO23516.1 - 0.0057 17.0 1.1 0.016 15.5 1.1 1.7 1 0 0 1 1 1 1 Syntaxin-like protein DUF19 PF01579.18 ETO23516.1 - 0.076 12.8 6.1 0.13 12.0 0.5 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF19) Abhydrolase_1 PF00561.20 ETO23518.1 - 1e-12 48.3 0.0 1.2e-12 48.0 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO23518.1 - 1.5e-11 44.0 0.0 2.1e-11 43.6 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO23518.1 - 2e-06 28.6 0.0 2.5e-06 28.2 0.0 1.0 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ETO23518.1 - 0.00013 21.9 0.0 0.00016 21.5 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase PGAP1 PF07819.13 ETO23518.1 - 0.0007 19.4 0.0 0.00092 19.0 0.0 1.2 1 0 0 1 1 1 1 PGAP1-like protein LIDHydrolase PF10230.9 ETO23518.1 - 0.0089 15.6 0.0 0.0095 15.5 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase DUF915 PF06028.11 ETO23518.1 - 0.035 13.4 0.0 0.062 12.6 0.0 1.4 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF915) Thioesterase PF00975.20 ETO23518.1 - 0.046 13.8 0.0 0.08 13.0 0.0 1.3 1 1 0 1 1 1 0 Thioesterase domain Esterase PF00756.20 ETO23518.1 - 0.048 13.3 0.0 0.052 13.2 0.0 1.1 1 0 0 1 1 1 0 Putative esterase DUF676 PF05057.14 ETO23518.1 - 0.063 12.8 0.0 0.086 12.3 0.0 1.4 1 1 0 1 1 1 0 Putative serine esterase (DUF676) Methyltransf_16 PF10294.9 ETO23519.1 - 1.1e-10 41.5 0.0 1.4e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase WD40 PF00400.32 ETO23521.1 - 1.1e-14 54.5 2.7 5.5e-07 30.2 0.7 4.3 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23521.1 - 2.4e-05 24.5 0.0 0.27 11.5 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23521.1 - 0.00017 20.7 0.0 0.12 11.3 0.0 2.2 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO23521.1 - 0.0039 17.1 1.6 0.9 9.6 0.1 3.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat POLO_box PF00659.18 ETO23521.1 - 0.063 13.5 0.4 5 7.4 0.0 3.0 3 1 0 3 3 3 0 POLO box duplicated region Proteasome_A_N PF10584.9 ETO23521.1 - 0.094 12.4 1.1 63 3.4 0.0 3.9 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature zf-TFIIIC PF12660.7 ETO23522.1 - 0.068 13.1 1.1 2.7 8.0 0.1 2.9 3 0 0 3 3 3 0 Putative zinc-finger of transcription factor IIIC complex Kinesin PF00225.23 ETO23523.1 - 2.9e-74 250.0 6.0 1.2e-73 247.9 3.0 2.7 1 1 1 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO23523.1 - 9.7e-18 64.5 0.1 9.7e-18 64.5 0.1 3.7 4 2 0 4 4 4 1 Microtubule binding PKcGMP_CC PF16808.5 ETO23523.1 - 0.0015 18.3 2.9 0.0015 18.3 2.9 3.8 5 0 0 5 5 5 1 Coiled-coil N-terminus of cGMP-dependent protein kinase Ni_hydr_CYTB PF01292.20 ETO23524.1 - 0.14 11.7 1.3 3 7.4 0.2 2.2 1 1 0 2 2 2 0 Prokaryotic cytochrome b561 RhoGAP PF00620.27 ETO23525.1 - 7e-05 22.7 0.2 0.00023 21.0 0.0 1.9 2 1 0 2 2 2 1 RhoGAP domain FAM221 PF14753.6 ETO23525.1 - 9.2e-05 22.1 1.3 0.00014 21.5 1.3 1.2 1 0 0 1 1 1 1 Protein FAM221A/B RhoGAP PF00620.27 ETO23527.1 - 2e-13 50.5 0.3 8.3e-12 45.2 0.3 2.1 1 1 0 1 1 1 1 RhoGAP domain DENN PF02141.21 ETO23528.1 - 3.4e-25 89.1 1.3 6.7e-25 88.1 0.4 2.0 2 0 0 2 2 2 1 DENN (AEX-3) domain dDENN PF03455.19 ETO23528.1 - 3.5e-06 26.9 1.6 9e-06 25.6 1.6 1.7 1 0 0 1 1 1 1 dDENN domain PPR_2 PF13041.6 ETO23528.1 - 2.8e-05 24.2 0.6 0.00021 21.4 0.0 2.5 2 0 0 2 2 2 1 PPR repeat family PPR_3 PF13812.6 ETO23528.1 - 0.027 14.5 0.0 0.097 12.8 0.0 1.9 2 0 0 2 2 2 0 Pentatricopeptide repeat domain PPR PF01535.20 ETO23528.1 - 0.2 12.0 0.0 0.2 12.0 0.0 2.2 2 0 0 2 2 2 0 PPR repeat RPA43_OB PF17875.1 ETO23528.1 - 1.3 9.7 6.0 2 9.0 0.1 3.2 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I DUF3614 PF12267.8 ETO23529.1 - 0.0041 17.6 0.6 0.0041 17.6 0.6 2.3 1 1 0 2 2 2 1 Protein of unknown function (DUF3614) SDA1 PF05285.12 ETO23530.1 - 0.059 12.8 8.8 0.059 12.8 8.8 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO23530.1 - 0.061 11.5 10.2 0.062 11.5 10.2 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO23530.1 - 0.16 10.3 12.1 0.16 10.2 12.1 1.0 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO23530.1 - 0.18 11.9 9.6 0.2 11.8 9.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein FAM176 PF14851.6 ETO23530.1 - 1.8 8.2 9.7 2.9 7.5 9.7 1.3 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 ETO23530.1 - 2 6.4 6.0 2 6.4 6.0 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 ETO23530.1 - 2 6.4 18.2 2.2 6.3 18.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF4637 PF15470.6 ETO23530.1 - 3.3 7.4 8.3 4.3 7.0 8.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) NAD_binding_5 PF07994.12 ETO23531.1 - 2.1e-72 244.3 0.0 2.5e-72 244.0 0.0 1.0 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Herpes_BBRF1 PF04793.12 ETO23531.1 - 0.13 11.2 0.0 0.19 10.7 0.0 1.3 1 0 0 1 1 1 0 BRRF1-like protein Inos-1-P_synth PF01658.17 ETO23532.1 - 1.2e-47 160.7 0.1 2.4e-47 159.7 0.1 1.5 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase NAD_binding_5 PF07994.12 ETO23532.1 - 4.3e-12 46.1 0.0 7.1e-12 45.3 0.0 1.4 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase DUF4834 PF16118.5 ETO23532.1 - 0.038 15.0 0.0 0.038 15.0 0.0 2.1 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) TSP_1 PF00090.19 ETO23532.1 - 1.6 9.0 5.3 4.2 7.7 5.3 1.7 1 1 0 1 1 1 0 Thrombospondin type 1 domain Glyco_transf_8 PF01501.20 ETO23533.1 - 9.2e-08 31.9 1.1 0.0052 16.4 0.9 2.9 2 1 0 2 2 2 2 Glycosyl transferase family 8 Orbi_VP3 PF01700.16 ETO23533.1 - 0.076 10.9 0.0 0.093 10.6 0.0 1.0 1 0 0 1 1 1 0 Orbivirus VP3 (T2) protein Pkinase PF00069.25 ETO23534.1 - 5.3e-21 75.2 1.3 1.4e-16 60.6 0.1 2.4 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23534.1 - 5.1e-07 29.2 0.3 1.7e-06 27.5 0.2 1.8 1 1 1 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO23534.1 - 0.0012 17.8 1.0 0.0029 16.4 0.9 1.8 1 1 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 ETO23534.1 - 0.0017 17.4 0.1 0.0028 16.7 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Apis_Csd PF11671.8 ETO23534.1 - 6.9 6.7 14.5 0.11 12.6 7.2 1.8 2 0 0 2 2 2 0 Complementary sex determiner protein RhoGEF PF00621.20 ETO23535.1 - 1.3e-06 28.8 0.1 1.9e-06 28.3 0.1 1.2 1 0 0 1 1 1 1 RhoGEF domain SOG2 PF10428.9 ETO23535.1 - 0.016 14.5 0.5 0.019 14.2 0.5 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Solute_trans_a PF03619.16 ETO23536.1 - 8.2e-09 35.4 1.2 1.2e-08 34.8 1.2 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha PDEase_I PF00233.19 ETO23537.1 - 1.4e-68 231.2 0.6 1.7e-68 230.9 0.6 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase SNF2_N PF00176.23 ETO23539.1 - 2.7e-50 171.1 3.3 5.2e-50 170.1 2.9 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO23539.1 - 2.7e-20 72.8 0.1 1.6e-19 70.3 0.0 2.4 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Chromo PF00385.24 ETO23539.1 - 9.8e-11 41.4 8.8 1.6e-06 28.0 1.4 3.6 3 1 0 3 3 3 2 Chromo (CHRromatin Organisation MOdifier) domain ResIII PF04851.15 ETO23539.1 - 5.6e-10 39.5 0.0 5.6e-10 39.5 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO23539.1 - 4.7e-08 33.0 0.1 5.2e-07 29.6 0.1 2.4 1 1 0 1 1 1 1 DEAD/DEAH box helicase HDA2-3 PF11496.8 ETO23539.1 - 6.3e-08 32.1 0.2 2.3e-06 27.0 0.0 3.1 2 1 0 2 2 2 1 Class II histone deacetylase complex subunits 2 and 3 FYRN PF05964.14 ETO23540.1 - 7.1e-13 48.2 0.4 1.5e-12 47.1 0.4 1.6 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 ETO23540.1 - 1.5e-12 47.5 2.3 2e-05 24.6 0.0 3.2 3 0 0 3 3 3 2 F/Y rich C-terminus 2OG-FeII_Oxy PF03171.20 ETO23541.1 - 4.1e-07 30.4 0.0 1.2e-06 28.9 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily MAPEG PF01124.18 ETO23542.1 - 0.00014 21.7 0.0 0.00033 20.6 0.0 1.6 1 0 0 1 1 1 1 MAPEG family DUF5453 PF17534.2 ETO23542.1 - 0.076 13.0 3.5 3 7.8 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5453) eIF3_p135 PF12807.7 ETO23543.1 - 0.056 13.5 0.6 0.081 13.0 0.6 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Nup188_C PF18378.1 ETO23543.1 - 0.084 11.7 0.1 0.11 11.3 0.1 1.1 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain zf-nanos PF05741.13 ETO23543.1 - 1.6 9.0 5.0 0.38 11.0 0.8 2.0 2 0 0 2 2 2 0 Nanos RNA binding domain Pkinase PF00069.25 ETO23544.1 - 1.7e-09 37.5 0.0 2.8e-09 36.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO23545.1 - 1.7e-31 109.6 1.0 1.5e-30 106.5 1.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23545.1 - 2.4e-12 46.7 0.1 2.5e-09 36.8 0.0 2.5 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO23545.1 - 0.00029 19.9 0.0 0.0005 19.1 0.0 1.3 1 0 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETO23545.1 - 0.051 12.9 0.1 0.087 12.2 0.1 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family SgrT PF15894.5 ETO23545.1 - 0.11 12.5 0.1 0.61 10.1 0.0 2.2 2 0 0 2 2 2 0 Inhibitor of glucose uptake transporter SgrT DUF5457 PF17540.2 ETO23545.1 - 0.13 12.4 0.2 2 8.6 0.0 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5457) APH PF01636.23 ETO23545.1 - 0.13 12.1 0.1 0.24 11.3 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family VWA PF00092.28 ETO23546.1 - 1.1e-05 25.8 0.0 0.0078 16.5 0.0 2.3 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 ETO23546.1 - 2e-05 25.2 0.0 0.038 14.7 0.0 2.7 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_CoxE PF05762.14 ETO23546.1 - 0.0022 17.4 0.0 0.24 10.7 0.0 2.2 2 0 0 2 2 2 2 VWA domain containing CoxE-like protein RHD3 PF05879.12 ETO23547.1 - 3.8e-05 22.1 0.1 0.00011 20.6 0.0 1.8 1 1 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ETO23547.1 - 0.00015 21.2 0.0 0.0005 19.4 0.0 1.9 1 0 0 1 1 1 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 ETO23547.1 - 0.0074 16.4 0.1 0.11 12.6 0.0 2.8 2 0 0 2 2 2 1 Dynamin family TPR_12 PF13424.6 ETO23548.1 - 0.0012 19.1 2.0 1.2 9.4 0.0 3.4 3 2 1 4 4 4 2 Tetratricopeptide repeat DUF4205 PF13898.6 ETO23548.1 - 0.0028 16.7 0.2 0.0057 15.6 0.2 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4205) TPR_19 PF14559.6 ETO23548.1 - 0.0063 17.0 3.2 0.49 10.9 0.1 3.2 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23548.1 - 0.018 15.0 0.8 23 5.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23548.1 - 0.035 14.2 5.8 0.66 10.2 0.2 4.5 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF3287 PF11690.8 ETO23548.1 - 0.098 12.4 0.1 0.2 11.4 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3287) PPR PF01535.20 ETO23548.1 - 0.15 12.4 0.1 1.1 9.7 0.0 2.4 3 0 0 3 3 3 0 PPR repeat TPR_8 PF13181.6 ETO23548.1 - 0.17 12.2 5.1 81 3.8 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23548.1 - 0.83 9.6 5.3 7.1 6.6 0.1 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO23548.1 - 1 9.7 3.4 3.2 8.0 0.0 3.2 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 OPT PF03169.15 ETO23552.1 - 0.072 11.7 4.1 0.1 11.2 4.1 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein RGS PF00615.19 ETO23553.1 - 0.0016 18.7 2.5 0.0032 17.7 2.5 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 ETO23554.1 - 6e-41 137.7 17.0 1.3e-06 29.0 0.6 8.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23554.1 - 1.5e-12 47.6 1.1 0.003 17.8 0.0 5.3 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23554.1 - 1.6e-08 33.7 2.5 0.99 8.0 0.0 5.1 2 1 3 5 5 5 5 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO23555.1 - 0.0017 18.6 3.3 1.5 9.2 0.1 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO23555.1 - 0.011 15.7 6.6 1.1 9.4 0.1 4.1 5 0 0 5 5 5 0 Kelch motif ADH_zinc_N PF00107.26 ETO23556.1 - 7.1e-11 42.2 0.1 1.2e-10 41.5 0.1 1.4 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO23556.1 - 3.8e-10 39.6 0.1 6.1e-10 38.9 0.1 1.3 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ETO23556.1 - 0.019 14.9 0.1 0.043 13.7 0.1 1.6 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase IFT20 PF14931.6 ETO23557.1 - 2.6e-32 111.5 7.3 3.2e-32 111.2 7.3 1.1 1 0 0 1 1 1 1 Intraflagellar transport complex B, subunit 20 MTS_N PF08468.11 ETO23557.1 - 0.012 15.7 3.4 1.6 8.8 1.7 2.1 2 0 0 2 2 2 0 Methyltransferase small domain N-terminal DUF848 PF05852.11 ETO23557.1 - 1 9.4 5.9 0.58 10.3 2.8 2.1 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) EF-hand_1 PF00036.32 ETO23558.1 - 0.011 15.3 4.5 1.6 8.4 0.1 3.3 3 0 0 3 3 3 0 EF hand ORF6C PF10552.9 ETO23558.1 - 0.029 14.4 0.5 0.029 14.4 0.5 3.4 3 1 0 3 3 3 0 ORF6C domain EF-hand_8 PF13833.6 ETO23558.1 - 0.037 13.9 0.4 3.6 7.5 0.0 2.9 2 0 0 2 2 2 0 EF-hand domain pair Phage_GP20 PF06810.11 ETO23558.1 - 0.067 13.0 28.1 0.6 9.9 1.8 3.6 1 1 2 3 3 3 0 Phage minor structural protein GP20 Sp38 PF07354.12 ETO23558.1 - 0.079 12.4 5.5 0.023 14.2 1.7 2.0 2 0 0 2 2 2 0 Zona-pellucida-binding protein (Sp38) CoA_transf_3 PF02515.17 ETO23558.1 - 0.12 11.4 2.2 1.8 7.6 0.0 2.1 2 0 0 2 2 2 0 CoA-transferase family III DUF4763 PF15960.5 ETO23558.1 - 0.23 10.8 30.9 1.7 7.9 0.2 4.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4763) APG6_N PF17675.1 ETO23558.1 - 2.1 8.9 41.7 14 6.2 21.7 3.4 1 1 1 2 2 2 0 Apg6 coiled-coil region EF-hand_7 PF13499.6 ETO23559.1 - 0.00048 20.5 0.5 0.0012 19.3 0.0 1.9 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO23559.1 - 0.0017 18.1 0.1 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ETO23559.1 - 0.01 15.7 0.1 0.026 14.4 0.1 1.7 1 0 0 1 1 1 0 EF-hand domain pair Cmc1 PF08583.10 ETO23560.1 - 0.00052 20.0 5.9 0.0013 18.7 5.9 1.7 1 0 0 1 1 1 1 Cytochrome c oxidase biogenesis protein Cmc1 like CbiG_mid PF11761.8 ETO23560.1 - 0.4 10.8 1.9 1.1 9.4 0.4 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis central region Iso_dh PF00180.20 ETO23563.1 - 3e-12 46.3 0.0 3.3e-12 46.2 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase Iso_dh PF00180.20 ETO23564.1 - 2.4e-38 132.2 0.0 3e-38 131.9 0.0 1.0 1 0 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF1107 PF06526.12 ETO23565.1 - 0.031 14.2 0.2 0.067 13.1 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1107) RcbX PF02341.15 ETO23565.1 - 0.24 11.7 1.9 0.26 11.6 0.5 1.7 2 0 0 2 2 2 0 RbcX protein TPR_12 PF13424.6 ETO23566.1 - 7.9e-20 70.9 7.4 2e-13 50.4 1.9 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO23566.1 - 3.3e-18 64.9 1.2 2.4e-07 30.4 0.6 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23566.1 - 4e-17 61.2 15.4 1.1e-08 34.5 3.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23566.1 - 9.5e-15 53.5 9.3 3.5e-07 29.8 1.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23566.1 - 2e-14 52.5 0.9 1.9e-05 24.3 0.3 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23566.1 - 1.4e-12 46.7 12.3 2.6e-06 27.2 1.8 3.9 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO23566.1 - 6.7e-08 32.1 11.2 4.2e-05 23.1 1.3 3.5 2 1 1 3 3 3 3 TPR repeat SNAP PF14938.6 ETO23566.1 - 5.4e-06 26.0 0.6 9.3e-06 25.3 0.6 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO23566.1 - 1.7e-05 25.1 1.3 0.057 14.1 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO23566.1 - 0.00064 19.9 3.4 0.53 10.8 0.8 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat DUF627 PF04781.12 ETO23566.1 - 0.00094 19.2 1.0 0.82 9.7 0.3 2.8 2 1 1 3 3 2 2 Protein of unknown function (DUF627) TPR_16 PF13432.6 ETO23566.1 - 0.0021 18.7 0.0 0.0063 17.1 0.0 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 ETO23566.1 - 0.0049 16.9 3.6 0.4 10.8 0.3 2.6 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO23566.1 - 0.012 15.4 7.2 0.25 11.1 0.5 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO23566.1 - 0.015 15.7 0.0 0.11 13.0 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO23566.1 - 0.024 15.4 0.0 4.6 8.3 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO23566.1 - 0.06 12.8 0.5 0.36 10.3 0.0 2.5 3 0 0 3 3 3 0 SHNi-TPR TPR_3 PF07720.12 ETO23566.1 - 0.12 12.4 6.0 2.2 8.3 0.5 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Aldedh PF00171.22 ETO23568.1 - 1.4e-54 185.4 0.3 1.1e-34 119.8 0.0 3.0 3 0 0 3 3 3 3 Aldehyde dehydrogenase family DUF1487 PF07368.11 ETO23568.1 - 0.00081 18.9 0.2 0.0021 17.6 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1487) Dala_Dala_lig_C PF07478.13 ETO23569.1 - 0.024 14.2 8.4 0.024 14.2 7.9 1.2 1 1 0 1 1 1 0 D-ala D-ala ligase C-terminus TM_PBP2_N PF16296.5 ETO23569.1 - 0.34 11.1 1.2 0.44 10.7 0.5 1.6 1 1 1 2 2 2 0 N-terminal of TM subunit in PBP-dependent ABC transporters Ribosomal_L6e PF01159.19 ETO23569.1 - 1.8 9.1 8.3 2.1 8.9 8.3 1.1 1 0 0 1 1 1 0 Ribosomal protein L6e NAP PF00956.18 ETO23569.1 - 2.4 7.3 12.4 3 6.9 12.4 1.0 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) HATPase_c_4 PF13749.6 ETO23570.1 - 0.094 12.9 0.1 0.3 11.2 0.1 1.9 1 0 0 1 1 1 0 Putative ATP-dependent DNA helicase recG C-terminal Chlam_PMP PF02415.17 ETO23572.1 - 5 7.8 11.0 59 4.5 0.1 4.6 4 1 0 4 4 4 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat DUF4045 PF13254.6 ETO23572.1 - 6.9 6.2 30.1 0.43 10.2 20.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4045) CdiI_2 PF18593.1 ETO23573.1 - 0.028 15.1 0.1 0.034 14.8 0.1 1.2 1 0 0 1 1 1 0 CdiI immunity protein DUF1688 PF07958.11 ETO23574.1 - 1.5e-132 442.4 0.3 4e-132 440.9 0.3 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF1688) GTP_cyclohydro2 PF00925.20 ETO23574.1 - 1.4e-16 60.5 0.0 4.3e-16 58.9 0.0 1.8 2 0 0 2 2 2 1 GTP cyclohydrolase II Q_salvage PF10343.9 ETO23574.1 - 1.1e-05 25.2 0.0 0.00084 19.0 0.0 2.2 2 0 0 2 2 2 1 Potential Queuosine, Q, salvage protein family GTP_CH_N PF12471.8 ETO23574.1 - 0.002 17.9 0.0 0.004 16.9 0.0 1.5 1 0 0 1 1 1 1 GTP cyclohydrolase N terminal Barstar PF01337.18 ETO23574.1 - 0.044 13.8 0.0 0.4 10.7 0.0 2.4 2 0 0 2 2 2 0 Barstar (barnase inhibitor) HD_assoc PF13286.6 ETO23576.1 - 0.22 12.1 1.2 1 10.0 0.3 2.5 2 0 0 2 2 2 0 Phosphohydrolase-associated domain PIP5K PF01504.18 ETO23577.1 - 2.1e-23 83.0 1.3 4.9e-23 81.7 1.3 1.6 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3855 PF12967.7 ETO23577.1 - 0.1 12.5 0.6 0.41 10.6 0.0 2.1 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3855) Ras PF00071.22 ETO23578.1 - 3.3e-14 52.8 0.4 0.00013 21.6 0.0 4.1 3 1 0 3 3 3 3 Ras family Roc PF08477.13 ETO23578.1 - 3.9e-08 33.5 0.7 2.4e-05 24.5 0.0 3.0 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO23578.1 - 3.4e-05 23.4 0.4 2.3 7.7 0.0 4.0 4 0 0 4 4 4 2 ADP-ribosylation factor family G-alpha PF00503.20 ETO23578.1 - 0.0018 17.5 1.9 0.003 16.8 0.1 2.0 2 0 0 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 ETO23578.1 - 0.019 14.3 2.1 1 8.6 0.5 2.5 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region DUF3439 PF11921.8 ETO23578.1 - 0.034 14.1 11.3 0.071 13.1 11.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO23578.1 - 1.2 7.3 12.7 1.9 6.6 12.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO23578.1 - 1.4 8.9 18.6 3.1 7.8 18.6 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein Iron_permease PF04120.12 ETO23579.1 - 1.6 8.5 3.8 24 4.7 0.1 2.6 2 1 0 2 2 2 0 Low affinity iron permease Voltage_CLC PF00654.20 ETO23581.1 - 3.2e-36 125.3 15.3 4e-31 108.5 9.5 2.1 2 0 0 2 2 2 2 Voltage gated chloride channel CBS PF00571.28 ETO23581.1 - 3.5e-07 30.6 0.0 0.0019 18.6 0.0 2.9 2 1 0 2 2 2 2 CBS domain RRM_1 PF00076.22 ETO23582.1 - 1.3e-51 172.3 0.0 7.5e-21 73.7 0.0 3.6 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO23582.1 - 2.6e-07 30.3 0.0 0.27 10.8 0.0 3.5 2 1 1 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO23582.1 - 0.00014 21.9 0.0 0.015 15.4 0.0 3.5 3 0 0 3 3 3 1 RNA recognition motif DUF4614 PF15391.6 ETO23582.1 - 0.00048 20.2 5.8 0.00048 20.2 5.8 3.4 2 1 0 2 2 2 1 Domain of unknown function (DUF4614) KxDL PF10241.9 ETO23584.1 - 0.0023 18.2 3.1 0.0043 17.3 3.1 1.4 1 0 0 1 1 1 1 Uncharacterized conserved protein Snapin_Pallidin PF14712.6 ETO23584.1 - 0.003 18.0 4.0 0.0047 17.3 4.0 1.3 1 0 0 1 1 1 1 Snapin/Pallidin DUF1664 PF07889.12 ETO23584.1 - 0.0048 16.9 1.7 0.0067 16.5 1.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1664) Phage_Mu_Gam PF07352.12 ETO23584.1 - 0.036 14.0 2.0 0.052 13.5 2.0 1.2 1 0 0 1 1 1 0 Bacteriophage Mu Gam like protein Rep_Org_C PF06926.11 ETO23584.1 - 0.051 13.9 0.4 0.081 13.3 0.4 1.3 1 0 0 1 1 1 0 Putative replisome organiser protein C-terminus THP2 PF09432.10 ETO23584.1 - 0.068 13.2 1.8 0.1 12.6 1.8 1.4 1 1 0 1 1 1 0 Tho complex subunit THP2 HnRNPA1 PF11627.8 ETO23585.1 - 0.039 14.2 2.2 0.18 12.0 2.3 2.1 2 0 0 2 2 2 0 Nuclear factor hnRNPA1 UPF0242 PF06785.11 ETO23585.1 - 1.1 9.3 23.3 0.098 12.8 15.3 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Spt20 PF12090.8 ETO23585.1 - 2 8.0 32.7 3.9 7.0 0.7 2.3 2 0 0 2 2 2 0 Spt20 family dCMP_cyt_deam_2 PF08211.12 ETO23585.1 - 4.3 7.5 8.8 1.2 9.3 1.8 3.1 3 0 0 3 3 3 0 Cytidine and deoxycytidylate deaminase zinc-binding region Neur_chan_memb PF02932.16 ETO23585.1 - 9.4 6.2 16.8 1.2 9.2 6.2 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Beta-lactamase PF00144.24 ETO23586.1 - 5.4e-48 163.9 0.0 7.1e-48 163.5 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase US6 PF17616.2 ETO23588.1 - 0.068 13.1 1.0 0.11 12.5 1.0 1.3 1 0 0 1 1 1 0 Viral unique short region 6 DUF1570 PF07607.11 ETO23588.1 - 0.084 13.2 0.1 0.46 10.8 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1570) DUF1398 PF07166.11 ETO23589.1 - 0.027 14.5 2.5 0.027 14.5 2.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1398) MTBP_C PF14920.6 ETO23589.1 - 0.19 11.5 14.1 0.24 11.1 14.1 1.1 1 0 0 1 1 1 0 MDM2-binding Menin PF05053.13 ETO23589.1 - 0.75 8.1 15.2 0.9 7.8 15.2 1.1 1 0 0 1 1 1 0 Menin DUF3212 PF11486.8 ETO23590.1 - 0.041 13.9 0.4 0.054 13.5 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3212) DUF4302 PF14135.6 ETO23590.1 - 0.52 10.2 4.2 0.17 11.8 1.6 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4302) DUF4200 PF13863.6 ETO23590.1 - 0.89 10.0 25.7 0.23 11.8 3.7 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) CRR7 PF12095.8 ETO23590.1 - 1.1 9.7 7.2 4.9 7.7 0.2 2.5 2 1 0 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 Tsg PF04668.12 ETO23590.1 - 1.6 9.4 5.3 0.69 10.6 0.3 2.0 1 1 1 2 2 2 0 Twisted gastrulation (Tsg) protein conserved region DUF948 PF06103.11 ETO23590.1 - 2.6 8.3 5.8 7.9 6.8 2.3 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Atg14 PF10186.9 ETO23590.1 - 2.9 6.9 15.4 12 4.8 11.2 2.0 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF1664 PF07889.12 ETO23590.1 - 5.9 7.0 13.8 1.5 8.8 8.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ETO23590.1 - 7.4 5.4 22.9 2.4 7.0 1.4 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Jnk-SapK_ap_N PF09744.9 ETO23591.1 - 0.0084 16.3 14.9 0.01 16.0 14.9 1.1 1 0 0 1 1 1 1 JNK_SAPK-associated protein-1 DUF4763 PF15960.5 ETO23591.1 - 0.012 15.0 10.5 0.014 14.7 10.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) TMF_TATA_bd PF12325.8 ETO23591.1 - 0.11 12.8 15.5 0.12 12.6 15.5 1.0 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Syntaxin PF00804.25 ETO23591.1 - 0.11 12.1 13.6 0.13 12.0 13.6 1.0 1 0 0 1 1 1 0 Syntaxin DUF4078 PF13300.6 ETO23591.1 - 0.14 12.5 9.1 0.44 10.9 9.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4078) Fib_alpha PF08702.10 ETO23591.1 - 0.4 10.9 13.2 0.41 10.8 13.2 1.0 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family OmpH PF03938.14 ETO23591.1 - 0.46 10.8 13.1 0.57 10.5 13.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Golgin_A5 PF09787.9 ETO23591.1 - 0.54 9.7 15.2 0.62 9.5 15.2 1.0 1 0 0 1 1 1 0 Golgin subfamily A member 5 CREPT PF16566.5 ETO23591.1 - 0.56 10.4 10.1 0.2 11.8 7.8 1.4 1 1 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour APG6_N PF17675.1 ETO23591.1 - 1.2 9.7 18.7 2.4 8.7 18.7 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region PhoU PF01895.19 ETO23591.1 - 1.2 9.6 7.5 8.6 6.9 7.5 2.0 1 1 0 1 1 1 0 PhoU domain DUF4806 PF16064.5 ETO23591.1 - 1.2 9.5 7.7 2.6 8.4 0.7 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4806) Macoilin PF09726.9 ETO23591.1 - 1.3 7.5 13.4 1.6 7.2 13.4 1.1 1 0 0 1 1 1 0 Macoilin family DUF4407 PF14362.6 ETO23591.1 - 1.8 7.9 9.3 1.9 7.7 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 ETO23591.1 - 1.8 7.8 11.0 2.1 7.6 11.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Nup88 PF10168.9 ETO23591.1 - 2.3 6.0 12.4 2.4 5.9 12.4 1.0 1 0 0 1 1 1 0 Nuclear pore component KMP11 PF03037.16 ETO23591.1 - 2.6 8.9 11.7 4.7 8.1 4.5 2.1 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 CENP-H PF05837.12 ETO23591.1 - 3.4 8.1 14.2 6.1 7.3 14.2 1.5 1 1 0 1 1 1 0 Centromere protein H (CENP-H) CASP_C PF08172.12 ETO23591.1 - 3.8 6.8 15.5 1.7 7.9 2.2 2.0 1 1 1 2 2 2 0 CASP C terminal Atg14 PF10186.9 ETO23591.1 - 4 6.4 12.2 4.8 6.2 12.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 ETO23591.1 - 4 7.5 17.5 4.7 7.3 17.5 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus S_4TM PF18159.1 ETO23591.1 - 5.5 6.2 9.1 2.7 7.2 3.0 1.7 1 1 1 2 2 2 0 SMODS-associating 4TM effector domain TMPIT PF07851.13 ETO23591.1 - 7.8 5.6 11.6 8.9 5.5 11.6 1.0 1 0 0 1 1 1 0 TMPIT-like protein TMEM220 PF15071.6 ETO23593.1 - 0.0086 16.8 1.8 0.0086 16.8 1.8 2.4 3 1 0 3 3 3 1 Transmembrane family 220, helix TMEM43 PF07787.12 ETO23593.1 - 0.046 13.1 1.1 0.1 12.0 1.1 1.5 1 0 0 1 1 1 0 Transmembrane protein 43 TMEM119 PF15724.5 ETO23594.1 - 0.032 14.3 0.1 0.047 13.8 0.1 1.3 1 0 0 1 1 1 0 TMEM119 family Calici_PP_N PF08405.11 ETO23594.1 - 0.065 12.0 0.0 0.097 11.5 0.0 1.3 1 0 0 1 1 1 0 Viral polyprotein N-terminal DUF1027 PF06265.11 ETO23595.1 - 0.12 12.4 0.0 0.23 11.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) PigN PF04987.14 ETO23596.1 - 0.23 10.3 0.4 0.49 9.2 0.3 1.5 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) YL1 PF05764.13 ETO23596.1 - 2.5 8.1 21.9 0.083 13.0 10.1 2.4 2 0 0 2 2 2 0 YL1 nuclear protein NOA36 PF06524.12 ETO23596.1 - 3 7.1 27.4 0.21 10.8 15.6 2.4 2 0 0 2 2 2 0 NOA36 protein Pox_RNA_Pol_19 PF05320.12 ETO23596.1 - 6 6.8 13.2 3.7 7.5 3.9 2.8 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit WWE PF02825.20 ETO23597.1 - 6.4e-14 52.3 10.2 6.8e-08 33.0 0.9 5.0 5 0 0 5 5 5 2 WWE domain Peptidase_S49_N PF08496.10 ETO23597.1 - 1.3 9.0 8.2 0.64 10.1 4.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Podoplanin PF05808.11 ETO23597.1 - 3.5 7.7 9.8 2.6 8.1 0.1 2.5 2 0 0 2 2 2 0 Podoplanin RNA_pol_3_Rpc31 PF11705.8 ETO23599.1 - 0.0036 17.6 15.9 0.0044 17.3 15.9 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 PPP4R2 PF09184.11 ETO23599.1 - 0.0076 15.9 14.9 0.0093 15.6 14.9 1.2 1 0 0 1 1 1 1 PPP4R2 VIR_N PF15912.5 ETO23599.1 - 0.057 13.0 19.4 0.078 12.6 19.4 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Nop14 PF04147.12 ETO23599.1 - 0.079 11.2 22.3 0.086 11.0 22.3 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO23599.1 - 0.15 11.4 22.1 0.17 11.3 22.1 1.1 1 0 0 1 1 1 0 SDA1 Serinc PF03348.15 ETO23599.1 - 0.17 10.8 3.6 0.22 10.4 3.6 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF5523 PF17661.1 ETO23599.1 - 0.2 11.3 23.3 0.31 10.7 23.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Spt20 PF12090.8 ETO23599.1 - 0.41 10.2 15.2 0.75 9.4 15.2 1.4 1 0 0 1 1 1 0 Spt20 family O-antigen_lig PF13425.6 ETO23599.1 - 0.52 9.0 6.5 0.83 8.4 6.5 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF913 PF06025.12 ETO23599.1 - 0.63 9.0 9.1 0.88 8.5 9.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RR_TM4-6 PF06459.12 ETO23599.1 - 1.3 8.8 16.5 1.9 8.3 16.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 V_ATPase_I PF01496.19 ETO23599.1 - 2.8 5.8 11.4 3.8 5.3 11.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SLC12 PF03522.15 ETO23599.1 - 3.1 6.7 10.0 3.7 6.5 10.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 FGF-BP1 PF06473.12 ETO23599.1 - 3.3 7.5 12.5 4.8 6.9 12.5 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Raftlin PF15250.6 ETO23599.1 - 6.2 5.5 15.1 24 3.5 0.0 2.1 2 0 0 2 2 2 0 Raftlin Presenilin PF01080.17 ETO23599.1 - 7 5.3 17.5 11 4.7 17.5 1.2 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO23599.1 - 7.4 5.2 14.9 13 4.5 14.9 1.4 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Hid1 PF12722.7 ETO23599.1 - 8.4 4.4 10.8 9.7 4.2 10.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NOA36 PF06524.12 ETO23599.1 - 9.3 5.5 27.2 3.1 7.0 24.5 1.5 2 0 0 2 2 2 0 NOA36 protein MOSC PF03473.17 ETO23600.1 - 0.054 13.5 0.7 0.11 12.6 0.7 1.4 1 0 0 1 1 1 0 MOSC domain GPHH PF16905.5 ETO23601.1 - 0.083 12.7 0.0 12 5.8 0.0 2.6 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated RWP-RK PF02042.15 ETO23601.1 - 0.34 10.9 2.0 2.6 8.1 0.1 3.0 2 1 0 2 2 2 0 RWP-RK domain CDC50 PF03381.15 ETO23602.1 - 7.7e-44 150.3 2.7 9.4e-44 150.0 2.7 1.1 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family Glyco_hydro_14 PF01373.17 ETO23602.1 - 0.016 14.2 0.0 0.025 13.5 0.0 1.2 1 0 0 1 1 1 0 Glycosyl hydrolase family 14 PagL PF09411.10 ETO23602.1 - 0.29 11.3 2.3 0.52 10.5 1.0 1.9 2 0 0 2 2 2 0 Lipid A 3-O-deacylase (PagL) DUF2839 PF10999.8 ETO23602.1 - 0.61 10.5 4.7 0.28 11.6 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2839) TIR-like PF10137.9 ETO23605.1 - 0.059 13.3 0.5 0.059 13.3 0.5 2.2 1 1 1 2 2 2 0 Predicted nucleotide-binding protein containing TIR-like domain DUF1664 PF07889.12 ETO23605.1 - 0.6 10.2 8.7 0.59 10.2 7.4 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMCO5 PF14992.6 ETO23605.1 - 0.68 9.5 18.9 0.9 9.1 18.9 1.2 1 0 0 1 1 1 0 TMCO5 family FlaC_arch PF05377.11 ETO23605.1 - 2.1 8.8 10.9 2.4 8.6 0.2 3.3 2 1 2 4 4 4 0 Flagella accessory protein C (FlaC) CENP-H PF05837.12 ETO23605.1 - 3.4 8.1 19.0 0.35 11.3 7.5 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) SHE3 PF17078.5 ETO23605.1 - 3.5 7.3 23.1 1.8 8.2 16.2 2.6 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 PRKG1_interact PF15898.5 ETO23605.1 - 3.9 8.4 18.8 2.6 9.0 12.6 2.3 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Tropomyosin_1 PF12718.7 ETO23605.1 - 5.7 7.1 21.9 0.94 9.6 10.3 2.8 1 1 2 3 3 3 0 Tropomyosin like OmpH PF03938.14 ETO23605.1 - 5.8 7.3 13.3 4.8 7.5 12.1 1.6 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FapA PF03961.13 ETO23605.1 - 5.8 5.4 11.3 7.2 5.1 11.3 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A Exonuc_VII_L PF02601.15 ETO23605.1 - 8.7 5.8 13.5 11 5.5 13.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF948 PF06103.11 ETO23605.1 - 9.3 6.6 7.8 6.5 7.1 3.0 2.2 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Myosin_head PF00063.21 ETO23606.1 - 1.9e-30 105.7 0.0 2.6e-30 105.3 0.0 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) Myosin_N PF02736.19 ETO23606.1 - 1.7e-10 40.6 0.3 3.1e-10 39.7 0.3 1.4 1 0 0 1 1 1 1 Myosin N-terminal SH3-like domain WW PF00397.26 ETO23606.1 - 2.1e-09 37.3 0.5 7.2e-09 35.6 0.5 1.9 1 0 0 1 1 1 1 WW domain RsgA_GTPase PF03193.16 ETO23606.1 - 0.11 12.4 0.0 0.26 11.2 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ETO23606.1 - 0.16 11.7 0.0 0.33 10.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO23606.1 - 0.66 10.5 2.6 0.52 10.8 0.4 1.9 2 1 0 2 2 2 0 ABC transporter EF-hand_1 PF00036.32 ETO23607.1 - 3.6e-11 41.8 2.6 0.00032 20.0 0.1 3.5 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ETO23607.1 - 1.7e-09 38.0 4.4 7e-06 26.4 2.7 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO23607.1 - 1.1e-08 34.3 0.2 0.0007 19.3 0.0 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ETO23607.1 - 1.6e-05 24.6 4.3 0.083 12.8 1.4 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO23607.1 - 0.0057 16.6 2.1 0.15 12.0 0.0 2.7 2 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO23607.1 - 0.029 14.7 4.3 0.13 12.6 4.3 2.0 1 1 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO23607.1 - 0.03 13.8 5.0 0.046 13.2 0.2 2.8 3 0 0 3 3 3 0 EF hand Guanylate_cyc PF00211.20 ETO23608.1 - 1.6e-07 31.1 0.2 1.7e-06 27.8 0.1 2.4 2 1 1 3 3 3 1 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 ETO23608.1 - 1.2e-05 25.8 0.0 2.3e-05 24.8 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain dNK PF01712.19 ETO23608.1 - 0.0026 17.7 0.0 0.036 13.9 0.0 2.5 2 0 0 2 2 2 1 Deoxynucleoside kinase DAP3 PF10236.9 ETO23608.1 - 0.047 12.9 0.0 0.085 12.0 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 NB-ARC PF00931.22 ETO23608.1 - 0.062 12.5 0.1 0.1 11.7 0.1 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 ETO23608.1 - 0.13 12.9 0.0 0.55 10.8 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO23608.1 - 0.13 12.5 0.0 0.61 10.4 0.0 2.1 1 1 1 2 2 2 0 AAA domain 2OG-FeII_Oxy_3 PF13640.6 ETO23609.1 - 0.00059 20.7 0.0 0.00096 20.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily TPR_12 PF13424.6 ETO23610.1 - 0.00038 20.7 0.0 0.00071 19.8 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23610.1 - 0.0048 16.9 0.0 0.012 15.7 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23610.1 - 0.0048 16.8 0.0 0.013 15.5 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23610.1 - 0.0097 15.7 0.0 0.02 14.7 0.0 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23610.1 - 0.021 15.0 0.0 0.076 13.3 0.0 1.9 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO23610.1 - 0.052 14.4 0.0 0.14 13.1 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat DUF4704 PF15787.5 ETO23611.1 - 2.5e-05 23.6 12.4 0.0076 15.5 4.3 3.3 3 1 0 3 3 3 2 Domain of unknown function (DUF4704) DUF5395 PF17373.2 ETO23611.1 - 0.1 13.3 0.0 0.4 11.4 0.0 2.0 1 0 0 1 1 1 0 Family of unknown function (DUF5395) MFS_1 PF07690.16 ETO23612.1 - 1.5e-12 47.1 11.8 4e-12 45.7 3.8 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_1_like PF12832.7 ETO23612.1 - 0.38 9.5 10.9 0.8 8.5 10.5 1.6 1 1 0 1 1 1 0 MFS_1 like family DUF202 PF02656.15 ETO23612.1 - 2 8.9 9.8 0.4 11.1 2.6 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF202) DUF2070 PF09843.9 ETO23612.1 - 6.1 5.0 12.8 8.1 4.6 12.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) ShK PF01549.24 ETO23613.1 - 2.3e-06 28.0 5.4 2.3e-06 28.0 5.4 2.0 2 0 0 2 2 2 1 ShK domain-like 2OG-FeII_Oxy_3 PF13640.6 ETO23613.1 - 0.11 13.4 0.2 0.38 11.7 0.1 2.0 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Peptidase_M4_C PF02868.15 ETO23614.1 - 0.0067 16.3 0.1 0.011 15.7 0.1 1.4 1 0 0 1 1 1 1 Thermolysin metallopeptidase, alpha-helical domain Microtub_bd PF16796.5 ETO23614.1 - 0.051 13.5 0.2 0.13 12.2 0.1 1.8 2 0 0 2 2 2 0 Microtubule binding Orthopox_B11R PF07033.11 ETO23614.1 - 0.23 11.3 1.1 0.35 10.7 0.3 1.7 2 0 0 2 2 2 0 Orthopoxvirus B11R protein DUF4666 PF15697.5 ETO23615.1 - 0.052 14.2 0.6 0.091 13.5 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4666) RGS PF00615.19 ETO23616.1 - 0.0073 16.6 1.4 0.011 16.0 1.4 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain Sec66 PF09802.9 ETO23617.1 - 0.0039 16.8 0.0 0.0067 16.0 0.0 1.3 1 0 0 1 1 1 1 Preprotein translocase subunit Sec66 WD40 PF00400.32 ETO23618.1 - 1.1e-36 124.1 25.8 9.2e-07 29.5 0.4 7.6 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23618.1 - 9.6e-11 41.8 0.6 0.14 12.5 0.0 5.6 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO23618.1 - 6.4e-09 35.0 8.4 0.04 12.6 0.7 5.4 1 1 3 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO23618.1 - 1.3e-05 24.7 4.7 0.33 10.2 0.1 4.4 2 2 3 5 5 5 3 WD40-like domain Eryth_link_C PF16915.5 ETO23618.1 - 0.01 15.8 0.8 0.41 10.7 0.0 3.4 2 1 1 4 4 4 0 Annelid erythrocruorin linker subunit C-terminus DUF851 PF05867.11 ETO23618.1 - 0.017 14.6 0.0 5.6 6.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF851) LRR_4 PF12799.7 ETO23619.1 - 0.011 16.2 2.3 0.034 14.6 0.1 3.0 3 0 0 3 3 3 0 Leucine Rich repeats (2 copies) DUF1018 PF06252.12 ETO23620.1 - 0.04 14.9 0.0 0.053 14.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1018) Arm_3 PF16186.5 ETO23621.1 - 0.044 13.3 0.0 0.096 12.3 0.0 1.6 1 1 0 1 1 1 0 Atypical Arm repeat WD40 PF00400.32 ETO23622.1 - 4.8e-50 166.5 25.0 1.4e-11 44.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23622.1 - 3.8e-17 62.4 0.6 8.6e-05 22.8 0.0 5.0 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23622.1 - 9.5e-12 44.5 0.9 0.14 11.1 0.0 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO23622.1 - 2.2e-09 37.5 3.0 0.0012 18.8 0.7 3.4 1 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO23622.1 - 8.4e-07 28.8 4.0 0.5 10.4 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO23622.1 - 3.9e-05 23.8 1.9 4.2 7.5 0.1 4.5 1 1 4 5 5 5 2 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO23622.1 - 9.9e-05 21.8 0.1 0.38 10.0 0.0 3.1 1 1 1 3 3 3 1 WD40-like domain Cytochrom_D1 PF02239.16 ETO23622.1 - 0.00019 20.1 0.1 0.013 14.0 0.0 2.3 1 1 0 2 2 2 2 Cytochrome D1 heme domain Frtz PF11768.8 ETO23622.1 - 0.00054 18.4 0.1 0.00098 17.6 0.1 1.3 1 0 0 1 1 1 1 WD repeat-containing and planar cell polarity effector protein Fritz Proteasome_A_N PF10584.9 ETO23622.1 - 0.013 15.1 9.6 23 4.8 0.2 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Nup160 PF11715.8 ETO23622.1 - 0.021 13.5 12.7 0.74 8.4 0.1 4.5 1 1 2 4 4 4 0 Nucleoporin Nup120/160 DUF769 PF05590.11 ETO23622.1 - 0.11 11.9 0.1 0.4 10.1 0.1 1.8 1 1 1 2 2 2 0 Xylella fastidiosa protein of unknown function (DUF769) CENP-B_dimeris PF09026.10 ETO23623.1 - 0.012 16.0 8.2 0.012 16.0 8.2 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RasGEF_N PF00618.20 ETO23623.1 - 0.025 14.8 0.0 0.025 14.8 0.0 2.5 2 1 0 2 2 2 0 RasGEF N-terminal motif V_ATPase_I PF01496.19 ETO23623.1 - 0.21 9.5 4.5 0.3 8.9 4.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cwf_Cwc_15 PF04889.12 ETO23623.1 - 0.28 10.9 22.8 0.015 15.0 16.1 2.1 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETO23623.1 - 1.6 8.0 13.4 3.3 6.9 13.4 1.5 1 0 0 1 1 1 0 NOA36 protein AAA PF00004.29 ETO23624.1 - 5.4e-09 36.6 0.1 2.3e-08 34.6 0.0 2.1 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Zot PF05707.12 ETO23624.1 - 0.01 15.5 0.1 0.028 14.1 0.1 1.7 1 0 0 1 1 1 0 Zonular occludens toxin (Zot) zf-C2H2_7 PF15269.6 ETO23626.1 - 0.1 12.7 1.5 0.15 12.1 0.2 2.0 2 0 0 2 2 2 0 Zinc-finger Herpes_LMP1 PF05297.11 ETO23626.1 - 2.3 7.3 6.0 3.2 6.8 6.0 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Utp14 PF04615.13 ETO23627.1 - 0.12 10.9 25.2 0.14 10.7 25.2 1.1 1 0 0 1 1 1 0 Utp14 protein Bactofilin PF04519.13 ETO23628.1 - 0.067 13.5 2.2 0.17 12.2 0.3 2.0 1 1 1 2 2 2 0 Polymer-forming cytoskeletal B56 PF01603.20 ETO23629.1 - 4.3e-67 226.9 28.5 4.6e-47 160.9 5.4 3.1 2 1 1 3 3 3 2 Protein phosphatase 2A regulatory B subunit (B56 family) TPR_19 PF14559.6 ETO23629.1 - 2.5e-08 34.3 1.2 2.5e-08 34.3 1.2 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO23629.1 - 1.6e-06 28.7 2.7 5.3e-05 23.8 0.1 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23629.1 - 1.7e-06 27.7 10.3 0.0028 17.7 0.5 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO23629.1 - 0.00013 22.5 0.2 0.5 11.3 0.1 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO23629.1 - 0.00019 21.0 2.7 0.36 10.5 0.0 2.8 2 0 0 2 2 2 2 TPR repeat TPR_1 PF00515.28 ETO23629.1 - 0.0016 18.2 12.2 0.022 14.6 1.3 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23629.1 - 0.0017 18.3 0.4 0.95 9.6 0.0 3.1 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO23629.1 - 0.0028 17.7 7.3 1.2 9.5 0.4 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO23629.1 - 0.017 15.4 4.1 0.2 12.0 1.3 3.0 1 1 1 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO23629.1 - 0.018 15.3 6.3 0.054 13.7 6.3 1.9 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 BTAD PF03704.17 ETO23629.1 - 0.062 13.7 0.2 0.25 11.8 0.1 2.0 2 0 0 2 2 2 0 Bacterial transcriptional activator domain TPR_17 PF13431.6 ETO23629.1 - 0.63 10.6 9.3 0.44 11.0 0.3 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Lzipper-MIP1 PF14389.6 ETO23629.1 - 4.2 7.7 10.9 6 7.3 0.3 3.1 3 0 0 3 3 2 0 Leucine-zipper of ternary complex factor MIP1 RR_TM4-6 PF06459.12 ETO23630.1 - 6.8 6.4 27.0 8.3 6.2 27.0 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Serpin PF00079.20 ETO23631.1 - 0.0031 16.9 0.5 1.1 8.4 0.1 3.3 3 1 0 3 3 3 2 Serpin (serine protease inhibitor) MAGI_u5 PF16666.5 ETO23631.1 - 0.26 11.5 0.1 0.26 11.5 0.1 2.0 2 0 0 2 2 2 0 Unstructured region on MAGI DUF4017 PF13209.6 ETO23631.1 - 2.7 8.0 5.8 6.3 6.8 1.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) adh_short_C2 PF13561.6 ETO23632.1 - 3.5e-17 62.7 0.0 4.5e-17 62.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO23632.1 - 5.5e-15 55.4 0.4 9e-15 54.6 0.4 1.3 1 1 0 1 1 1 1 short chain dehydrogenase Epimerase PF01370.21 ETO23632.1 - 1.8e-08 34.1 0.0 4.1e-08 33.0 0.0 1.5 1 1 1 2 2 2 1 NAD dependent epimerase/dehydratase family KR PF08659.10 ETO23632.1 - 0.00017 21.6 0.1 0.00071 19.5 0.1 1.9 1 1 0 1 1 1 1 KR domain Semialdhyde_dh PF01118.24 ETO23632.1 - 0.0003 21.2 0.1 0.0052 17.2 0.1 2.1 1 1 0 1 1 1 1 Semialdehyde dehydrogenase, NAD binding domain NAD_binding_10 PF13460.6 ETO23632.1 - 0.0021 18.0 0.0 0.0084 16.0 0.0 1.8 1 1 1 2 2 2 1 NAD(P)H-binding 3Beta_HSD PF01073.19 ETO23632.1 - 0.0031 16.6 0.1 0.0038 16.3 0.1 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family DapB_N PF01113.20 ETO23632.1 - 0.0089 16.1 0.1 0.022 14.9 0.0 1.7 2 0 0 2 2 2 1 Dihydrodipicolinate reductase, N-terminus DUF1776 PF08643.10 ETO23632.1 - 0.014 14.8 0.0 0.018 14.4 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) Sacchrp_dh_NADP PF03435.18 ETO23632.1 - 0.022 15.0 0.1 0.054 13.8 0.0 1.6 1 1 0 2 2 2 0 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ETO23632.1 - 0.024 15.2 0.1 0.074 13.7 0.0 1.9 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_4 PF07993.12 ETO23632.1 - 0.15 11.2 0.0 0.23 10.6 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein Plasmid_parti PF01672.16 ETO23633.1 - 0.51 11.0 8.3 2.4 8.9 4.8 2.4 1 1 1 2 2 2 0 Putative plasmid partition protein ECH_1 PF00378.20 ETO23634.1 - 7.8e-78 261.2 0.3 6.2e-64 215.7 0.3 2.0 2 0 0 2 2 2 2 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO23634.1 - 2.3e-34 119.4 1.4 5.2e-24 85.4 0.5 2.7 2 1 0 2 2 2 2 Enoyl-CoA hydratase/isomerase Peptidase_S49 PF01343.18 ETO23634.1 - 0.032 14.2 0.1 1.3 9.0 0.0 2.3 2 0 0 2 2 2 0 Peptidase family S49 tRNA_lig_CPD PF08302.11 ETO23636.1 - 2.6e-07 30.4 0.0 2.2e-06 27.3 0.0 1.9 1 1 0 2 2 2 1 Fungal tRNA ligase phosphodiesterase domain WD40 PF00400.32 ETO23637.1 - 1.7e-23 82.4 17.0 2.1e-05 25.2 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23637.1 - 3.7e-07 30.3 3.9 1.3 9.4 0.0 5.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Macoilin PF09726.9 ETO23638.1 - 0.031 12.8 14.7 0.034 12.7 14.7 1.1 1 0 0 1 1 1 0 Macoilin family Neur_chan_memb PF02932.16 ETO23638.1 - 0.073 13.1 0.8 0.086 12.9 0.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 ETO23638.1 - 0.12 11.1 11.0 0.15 10.8 11.0 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO23638.1 - 0.14 10.5 11.9 0.17 10.3 11.9 1.2 1 0 0 1 1 1 0 Menin Tim54 PF11711.8 ETO23638.1 - 0.38 9.5 6.2 0.62 8.8 6.2 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO23638.1 - 0.71 9.0 5.8 0.79 8.9 5.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO23638.1 - 1.5 7.5 10.7 1.7 7.3 10.7 1.2 1 0 0 1 1 1 0 Presenilin TPR_12 PF13424.6 ETO23639.1 - 1e-11 45.0 0.2 0.00014 22.1 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23639.1 - 2.8e-07 30.1 1.7 2.8e-07 30.1 1.7 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO23639.1 - 4e-07 29.7 0.9 1.2e-06 28.1 0.3 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO23639.1 - 4.4e-06 26.3 0.5 4.4e-06 26.3 0.5 2.5 3 0 0 3 3 3 1 TPR repeat TPR_10 PF13374.6 ETO23639.1 - 0.00033 20.4 5.2 0.006 16.4 0.7 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO23639.1 - 0.00091 19.1 0.6 0.0039 17.1 0.1 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO23639.1 - 0.0058 17.2 0.0 0.0094 16.6 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO23639.1 - 0.0089 16.6 0.0 0.026 15.1 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat RPN7 PF10602.9 ETO23639.1 - 0.024 14.3 0.1 0.06 13.0 0.0 1.6 1 1 0 1 1 1 0 26S proteasome subunit RPN7 TPR_8 PF13181.6 ETO23639.1 - 0.029 14.6 0.7 0.029 14.6 0.7 2.9 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO23639.1 - 0.094 13.1 0.2 0.094 13.1 0.2 2.9 3 1 0 3 3 2 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO23639.1 - 0.11 12.2 3.1 4 7.1 3.1 2.1 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) Amidase PF01425.21 ETO23640.1 - 3.4e-61 207.6 0.0 1.7e-60 205.3 0.0 1.9 1 1 0 1 1 1 1 Amidase PH PF00169.29 ETO23641.1 - 2.4e-06 28.0 7.8 3e-06 27.7 5.0 2.5 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO23641.1 - 0.0035 17.6 0.1 0.0094 16.2 0.1 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain MR_MLE_C PF13378.6 ETO23642.1 - 3.2e-32 111.9 0.0 7.6e-32 110.7 0.0 1.6 1 1 0 1 1 1 1 Enolase C-terminal domain-like MR_MLE_N PF02746.16 ETO23642.1 - 5.3e-12 46.0 0.0 9e-12 45.2 0.0 1.3 1 0 0 1 1 1 1 Mandelate racemase / muconate lactonizing enzyme, N-terminal domain Asp_Glu_race PF01177.22 ETO23643.1 - 1.6e-32 113.2 0.1 2e-32 112.8 0.1 1.1 1 0 0 1 1 1 1 Asp/Glu/Hydantoin racemase PTA_PTB PF01515.19 ETO23643.1 - 0.049 12.9 0.0 0.074 12.4 0.0 1.2 1 0 0 1 1 1 0 Phosphate acetyl/butaryl transferase Adhesin_P1_N PF18652.1 ETO23647.1 - 0.042 13.9 0.9 0.042 13.9 0.9 2.5 2 0 0 2 2 2 0 Adhesin P1 N-terminal domain PYNP_C PF07831.13 ETO23647.1 - 0.085 12.5 0.2 0.19 11.4 0.2 1.7 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain CotJB PF12652.7 ETO23647.1 - 0.27 11.5 2.2 1.9 8.7 1.0 2.9 1 1 1 2 2 2 0 CotJB protein PI_PP_I PF18363.1 ETO23647.1 - 3.6 7.8 8.6 9.9 6.4 0.8 3.1 3 0 0 3 3 3 0 Phosphoinositide phosphatase insertion domain Bcr-Abl_Oligo PF09036.10 ETO23647.1 - 5 7.2 12.5 9.9 6.2 6.6 3.6 2 1 1 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain Imm42 PF15593.6 ETO23647.1 - 5.5 7.4 13.7 0.22 12.0 6.6 2.3 2 1 0 2 2 2 0 Immunity protein 42 PhyH PF05721.13 ETO23648.1 - 1.6e-06 28.6 0.0 0.0059 16.9 0.0 2.9 2 0 0 2 2 2 2 Phytanoyl-CoA dioxygenase (PhyH) Myco_arth_vir_N PF09610.10 ETO23648.1 - 0.069 13.2 0.1 0.069 13.2 0.1 2.0 2 0 0 2 2 2 0 Mycoplasma virulence signal region (Myco_arth_vir_N) RhoGEF PF00621.20 ETO23649.1 - 8.2e-14 52.2 5.4 1.3e-12 48.4 5.4 2.4 1 1 0 1 1 1 1 RhoGEF domain DUF2197 PF09963.9 ETO23649.1 - 0.014 15.7 2.1 0.071 13.4 2.1 2.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2197) DUF5101 PF17031.5 ETO23650.1 - 0.00025 21.1 1.9 0.00055 20.0 1.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5101) FYVE PF01363.21 ETO23650.1 - 0.0021 18.2 1.1 0.0042 17.2 1.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger ZapB PF06005.12 ETO23650.1 - 0.0052 17.2 4.3 0.0052 17.2 4.3 2.0 2 0 0 2 2 2 1 Cell division protein ZapB CENP-Q PF13094.6 ETO23650.1 - 0.019 15.1 6.2 0.042 14.1 6.2 1.6 1 0 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit UPF0242 PF06785.11 ETO23650.1 - 0.064 13.4 3.8 0.13 12.4 3.8 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PHM7_cyt PF14703.6 ETO23650.1 - 0.12 12.6 2.1 0.22 11.8 2.1 1.4 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter YabA PF06156.13 ETO23650.1 - 1.1 9.9 3.8 3.2 8.5 3.8 1.8 1 0 0 1 1 1 0 Initiation control protein YabA bZIP_2 PF07716.15 ETO23650.1 - 5 7.3 10.8 0.091 12.9 3.5 1.9 2 0 0 2 2 2 0 Basic region leucine zipper CCDC106 PF15794.5 ETO23650.1 - 6.2 6.5 12.6 0.078 12.7 3.5 2.3 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Dor1 PF04124.12 ETO23651.1 - 1.9e-48 164.9 11.1 2.4e-48 164.6 11.1 1.0 1 0 0 1 1 1 1 Dor1-like family Vps54_N PF10475.9 ETO23651.1 - 0.0039 16.5 7.9 0.0067 15.8 7.9 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex MetOD1 PF18546.1 ETO23651.1 - 0.16 11.9 2.4 0.37 10.7 0.7 2.2 2 0 0 2 2 2 0 Metanogen output domain 1 Vps51 PF08700.11 ETO23651.1 - 0.64 10.1 5.3 0.28 11.3 2.3 1.9 2 0 0 2 2 2 0 Vps51/Vps67 bZIP_2 PF07716.15 ETO23651.1 - 1.7 8.8 11.6 2.8 8.1 1.2 3.2 2 0 0 2 2 2 0 Basic region leucine zipper DUF853 PF05872.12 ETO23652.1 - 0.031 12.9 0.1 0.037 12.6 0.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) MADF_DNA_bdg PF10545.9 ETO23652.1 - 0.11 12.8 0.8 0.22 11.9 0.8 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase transcription factor Myb/SANT-like YtxH PF12732.7 ETO23652.1 - 4.3 7.9 7.0 11 6.7 7.0 1.8 1 1 0 1 1 1 0 YtxH-like protein SAM_1 PF00536.30 ETO23654.1 - 0.011 16.2 0.3 0.084 13.3 0.3 2.5 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO23654.1 - 0.048 13.8 0.3 0.12 12.5 0.3 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Zip PF02535.22 ETO23655.1 - 0.5 9.5 5.4 0.056 12.7 0.6 1.9 2 1 0 2 2 2 0 ZIP Zinc transporter Apis_Csd PF11671.8 ETO23655.1 - 0.62 10.1 20.0 1.2 9.2 20.0 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein DuoxA PF10204.9 ETO23655.1 - 1.4 7.8 5.8 0.21 10.6 1.5 1.7 2 0 0 2 2 2 0 Dual oxidase maturation factor Menin PF05053.13 ETO23655.1 - 4.5 5.5 9.8 6.2 5.0 9.8 1.3 1 0 0 1 1 1 0 Menin DUF2076 PF09849.9 ETO23655.1 - 5.4 7.0 12.2 7.5 6.5 12.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) NOA36 PF06524.12 ETO23655.1 - 9.8 5.4 9.5 21 4.3 9.5 1.5 1 0 0 1 1 1 0 NOA36 protein Podoplanin PF05808.11 ETO23657.1 - 2.9 8.0 5.9 3.7 7.6 5.9 1.2 1 0 0 1 1 1 0 Podoplanin Cir_N PF10197.9 ETO23659.1 - 3.5e-07 30.3 8.4 3.5e-07 30.3 8.4 4.3 4 0 0 4 4 4 1 N-terminal domain of CBF1 interacting co-repressor CIR Androgen_recep PF02166.16 ETO23659.1 - 0.0049 15.8 0.7 0.0079 15.1 0.7 1.2 1 0 0 1 1 1 1 Androgen receptor DUF5021 PF16424.5 ETO23659.1 - 0.069 13.0 0.1 0.13 12.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5021) CrgA PF06781.12 ETO23659.1 - 0.18 11.9 4.4 6 7.0 0.2 3.1 2 0 0 2 2 2 0 Cell division protein CrgA VGCC_beta4Aa_N PF12052.8 ETO23659.1 - 0.22 11.7 2.9 0.96 9.6 2.9 2.2 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal DUF1980 PF09323.10 ETO23660.1 - 2.7 7.9 5.9 6.5 6.6 3.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Hist_deacetyl PF00850.19 ETO23663.1 - 3.9e-74 249.9 0.0 1e-73 248.5 0.0 1.8 2 0 0 2 2 2 1 Histone deacetylase domain Neur_chan_memb PF02932.16 ETO23663.1 - 2.1 8.3 5.5 3 7.8 0.2 2.8 2 1 1 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 ETO23665.1 - 0.072 12.4 2.6 0.12 11.8 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CDC45 PF02724.14 ETO23665.1 - 0.46 8.7 15.2 0.61 8.3 15.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Macoilin PF09726.9 ETO23665.1 - 1.1 7.7 21.8 1.5 7.3 21.8 1.3 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 ETO23665.1 - 1.6 7.9 7.8 2.4 7.3 7.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4175 PF13779.6 ETO23665.1 - 2.1 6.1 6.4 2.9 5.7 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Dsh_C PF12316.8 ETO23665.1 - 2.2 8.7 7.5 3.4 8.0 7.5 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Striatin PF08232.12 ETO23665.1 - 3.5 8.2 13.1 7.3 7.2 13.1 1.5 1 0 0 1 1 1 0 Striatin family Gti1_Pac2 PF09729.9 ETO23665.1 - 8.6 6.4 17.5 21 5.1 17.5 1.7 1 0 0 1 1 1 0 Gti1/Pac2 family RGS PF00615.19 ETO23666.1 - 3e-05 24.3 4.7 0.00017 21.8 0.4 2.9 3 0 0 3 3 3 2 Regulator of G protein signaling domain Histone PF00125.24 ETO23667.1 - 5.9e-32 110.8 8.2 4.8e-31 107.8 0.8 2.3 2 0 0 2 2 2 2 Core histone H2A/H2B/H3/H4 CENP-S PF15630.6 ETO23667.1 - 5.9e-05 23.4 0.0 0.00011 22.5 0.0 1.4 1 0 0 1 1 1 1 CENP-S protein CENP-T_C PF15511.6 ETO23667.1 - 0.00047 20.2 0.1 0.00084 19.4 0.1 1.3 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold CBFD_NFYB_HMF PF00808.23 ETO23667.1 - 0.014 15.7 0.2 0.031 14.6 0.1 1.6 2 0 0 2 2 2 0 Histone-like transcription factor (CBF/NF-Y) and archaeal histone WRW PF10206.9 ETO23667.1 - 0.022 15.1 1.2 0.044 14.2 1.2 1.4 1 0 0 1 1 1 0 Mitochondrial F1F0-ATP synthase, subunit f PAF PF15715.5 ETO23667.1 - 0.11 13.1 2.9 0.21 12.2 2.9 1.5 1 0 0 1 1 1 0 PCNA-associated factor histone like domain DUF5360 PF17314.2 ETO23668.1 - 0.027 14.6 0.0 0.039 14.0 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5360) CTU2 PF10288.9 ETO23668.1 - 0.12 12.6 0.1 0.16 12.2 0.1 1.4 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Arrestin_N PF00339.29 ETO23669.1 - 0.087 12.9 0.7 0.11 12.6 0.7 1.5 1 1 0 1 1 1 0 Arrestin (or S-antigen), N-terminal domain BAALC_N PF06989.12 ETO23669.1 - 0.36 11.2 2.0 4 7.8 0.7 2.1 2 0 0 2 2 2 0 BAALC N-terminus RGS PF00615.19 ETO23671.1 - 5.5e-08 33.1 0.6 9.9e-08 32.3 0.6 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain ADK_lid PF05191.14 ETO23672.1 - 2.1e-12 46.8 0.2 1.2e-08 34.7 0.1 2.6 2 0 0 2 2 2 2 Adenylate kinase, active site lid ADK PF00406.22 ETO23672.1 - 3.7e-09 36.8 0.0 7.8e-09 35.8 0.0 1.6 1 0 0 1 1 1 1 Adenylate kinase FliJ PF02050.16 ETO23672.1 - 0.34 11.1 8.4 0.67 10.2 8.4 1.4 1 0 0 1 1 1 0 Flagellar FliJ protein HTH_ABP1_N PF18107.1 ETO23674.1 - 0.53 10.0 3.0 0.48 10.2 0.7 2.1 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain RIH_assoc PF08454.11 ETO23674.1 - 1.1 9.2 4.9 26 4.7 5.0 2.7 1 1 0 1 1 1 0 RyR and IP3R Homology associated DUF4363 PF14276.6 ETO23674.1 - 1.6 8.9 5.2 2.3 8.4 0.1 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4363) Ion_trans PF00520.31 ETO23676.1 - 2.2e-32 112.2 1.9 2.6e-32 112.0 1.9 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO23676.1 - 0.016 13.9 0.9 1.2 7.7 0.0 2.3 1 1 1 2 2 2 0 Polycystin cation channel Pkinase PF00069.25 ETO23677.1 - 9.1e-45 153.1 1.8 3.1e-24 85.8 0.0 3.0 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23677.1 - 7.8e-23 81.1 0.0 2.1e-13 50.2 0.0 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO23677.1 - 6.1e-06 25.7 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO23677.1 - 3.5e-05 23.3 0.0 0.027 13.8 0.0 2.3 2 0 0 2 2 2 2 Kinase-like DUF410 PF04190.13 ETO23678.1 - 0.031 14.1 0.3 0.32 10.8 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF410) Paz_1 PF18349.1 ETO23678.1 - 0.095 12.7 0.0 0.21 11.6 0.0 1.5 1 0 0 1 1 1 0 PAZ domain Vac14_Fab1_bd PF12755.7 ETO23680.1 - 5.7e-22 78.1 0.2 2e-21 76.4 0.0 1.9 2 0 0 2 2 2 1 Vacuolar 14 Fab1-binding region HEAT PF02985.22 ETO23680.1 - 9.6e-05 22.3 0.0 0.0041 17.3 0.0 2.5 2 0 0 2 2 2 1 HEAT repeat LidA_Long_CC PF18641.1 ETO23680.1 - 0.00041 20.5 2.5 0.00064 19.8 2.5 1.2 1 0 0 1 1 1 1 LidA long coiled-coil domain Vac14_Fab1_bd PF12755.7 ETO23681.1 - 0.00052 20.6 0.0 0.82 10.3 0.0 2.2 2 0 0 2 2 2 2 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO23681.1 - 0.0018 17.9 0.2 1.3 8.5 0.0 2.9 2 1 1 3 3 3 1 CLASP N terminal Cnd1 PF12717.7 ETO23681.1 - 0.0024 17.9 0.3 0.03 14.4 0.1 2.0 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DNA_pol_phi PF04931.13 ETO23681.1 - 0.0037 15.4 6.0 0.004 15.3 6.0 1.3 1 0 0 1 1 1 1 DNA polymerase phi GCFC PF07842.12 ETO23681.1 - 0.0038 16.9 1.2 0.021 14.5 0.3 2.0 2 0 0 2 2 2 1 GC-rich sequence DNA-binding factor-like protein CDC45 PF02724.14 ETO23681.1 - 0.0071 14.7 2.6 0.0074 14.6 2.6 1.1 1 0 0 1 1 1 1 CDC45-like protein RsbRD_N PF14361.6 ETO23681.1 - 0.011 16.4 0.2 1.8 9.3 0.0 2.5 2 1 0 2 2 2 0 RsbT co-antagonist protein rsbRD N-terminal domain Tti2 PF10521.9 ETO23681.1 - 0.014 14.9 1.2 0.41 10.1 0.2 2.1 1 1 0 2 2 2 0 Tti2 family SGT1 PF07093.11 ETO23681.1 - 0.022 13.2 3.3 0.029 12.8 3.3 1.1 1 0 0 1 1 1 0 SGT1 protein RRN3 PF05327.11 ETO23681.1 - 0.16 10.5 3.5 0.18 10.3 3.5 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Vac14_Fig4_bd PF11916.8 ETO23682.1 - 1.4e-29 103.1 1.0 1.4e-29 103.1 1.0 1.7 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding MMS19_C PF12460.8 ETO23682.1 - 0.00066 18.9 1.3 0.00094 18.4 1.3 1.2 1 0 0 1 1 1 1 RNAPII transcription regulator C-terminal Arm PF00514.23 ETO23682.1 - 0.0027 17.7 1.0 0.045 13.8 0.4 2.4 2 0 0 2 2 2 1 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ETO23682.1 - 0.011 15.9 0.5 0.029 14.6 0.2 1.9 2 0 0 2 2 2 0 HEAT repeat Cnd1 PF12717.7 ETO23682.1 - 0.017 15.1 0.6 0.029 14.4 0.3 1.6 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO23682.1 - 0.041 14.4 0.1 0.089 13.3 0.1 1.6 1 0 0 1 1 1 0 HEAT-like repeat Vac14_Fig4_bd PF11916.8 ETO23683.1 - 8.9e-24 84.1 1.3 8.9e-24 84.1 1.3 1.9 2 0 0 2 2 2 1 Vacuolar protein 14 C-terminal Fig4p binding DUF4868 PF16162.5 ETO23683.1 - 0.019 14.9 0.5 0.03 14.3 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4868) Torus PF16131.5 ETO23684.1 - 0.0026 18.4 0.4 0.0026 18.4 0.4 1.8 2 0 0 2 2 2 1 Torus domain zf-CCCH PF00642.24 ETO23684.1 - 0.02 14.8 4.5 0.032 14.1 4.5 1.3 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) DUF1943 PF09172.11 ETO23685.1 - 0.023 14.0 3.5 0.026 13.8 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) DUF3194 PF11419.8 ETO23685.1 - 1.3 9.4 18.3 1.3 9.4 10.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3194) EF-hand_6 PF13405.6 ETO23686.1 - 0.046 13.7 0.6 0.23 11.5 0.2 2.3 2 0 0 2 2 2 0 EF-hand domain YqzE PF14038.6 ETO23686.1 - 1.2 9.2 9.1 2.7 8.1 9.1 1.6 1 0 0 1 1 1 0 YqzE-like protein ARID PF01388.21 ETO23687.1 - 2e-16 60.4 0.4 2e-16 60.4 0.4 1.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain zf-CW PF07496.15 ETO23687.1 - 5.1e-15 55.2 7.4 1.2e-14 54.0 7.4 1.7 1 0 0 1 1 1 1 CW-type Zinc Finger TFIIA PF03153.13 ETO23687.1 - 0.00045 20.3 12.1 0.00054 20.1 12.1 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit zf-UBP PF02148.19 ETO23687.1 - 0.14 12.5 0.3 0.14 12.5 0.3 2.8 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein Spt20 PF12090.8 ETO23687.1 - 1.2 8.7 24.2 2.4 7.7 24.2 1.4 1 0 0 1 1 1 0 Spt20 family Pex14_N PF04695.13 ETO23687.1 - 4.2 8.0 16.5 7.9 7.1 16.5 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Presenilin PF01080.17 ETO23687.1 - 5.9 5.5 11.1 9.8 4.8 11.1 1.3 1 0 0 1 1 1 0 Presenilin zf-C2H2_4 PF13894.6 ETO23688.1 - 7.3e-14 51.3 26.6 0.00026 21.5 1.3 5.3 5 0 0 5 5 5 4 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO23688.1 - 4e-11 42.7 25.1 0.0011 19.3 1.1 4.8 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ETO23688.1 - 1.1e-09 38.1 16.6 0.021 14.8 0.7 4.5 4 0 0 4 4 4 4 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO23688.1 - 2e-07 31.1 21.7 0.00015 22.0 2.2 4.3 5 0 0 5 5 5 3 Zinc-finger double domain zf-C2H2_8 PF15909.5 ETO23688.1 - 4.8e-06 26.8 2.6 4.8e-06 26.8 2.6 2.3 1 1 1 2 2 2 1 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ETO23688.1 - 1.2e-05 25.5 18.7 0.0017 18.6 0.5 4.8 5 0 0 5 5 5 2 Zinc-finger double-stranded RNA-binding Mis12 PF05859.12 ETO23688.1 - 0.0038 17.3 0.0 0.0038 17.3 0.0 1.3 1 1 0 1 1 1 1 Mis12 protein zf-CHCC PF10276.9 ETO23688.1 - 0.0076 16.3 2.2 0.15 12.1 0.1 2.5 2 0 0 2 2 2 1 Zinc-finger domain zf-BED PF02892.15 ETO23688.1 - 0.015 15.3 22.9 0.48 10.5 3.6 4.1 2 1 2 4 4 4 0 BED zinc finger zf_UBZ PF18439.1 ETO23688.1 - 0.017 14.7 6.4 4.2 7.0 0.3 3.5 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-MYST PF17772.1 ETO23688.1 - 0.025 14.2 15.9 0.079 12.6 1.0 3.7 4 0 0 4 4 4 0 MYST family zinc finger domain zf-C2H2_2 PF12756.7 ETO23688.1 - 0.12 12.8 17.6 4.1 7.8 2.8 3.2 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-met PF12874.7 ETO23688.1 - 0.13 12.7 0.7 0.13 12.7 0.7 5.3 6 0 0 6 6 6 0 Zinc-finger of C2H2 type zf-C2H2_9 PF16293.5 ETO23688.1 - 0.27 11.1 6.6 2.6 8.0 0.3 2.7 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-AN1 PF01428.16 ETO23688.1 - 9 6.6 20.2 0.7 10.1 1.2 4.5 4 1 0 4 4 4 0 AN1-like Zinc finger zf-TRAF PF02176.18 ETO23689.1 - 0.00037 21.1 9.5 0.00037 21.1 9.5 2.7 2 2 0 2 2 2 1 TRAF-type zinc finger C1q PF00386.21 ETO23689.1 - 0.018 15.2 0.4 0.092 13.0 0.1 2.2 2 0 0 2 2 2 0 C1q domain CPW_WPC PF09717.10 ETO23689.1 - 0.028 15.4 2.2 0.028 15.4 2.2 3.6 2 1 2 4 4 4 0 Plasmodium falciparum domain of unknown function (CPW_WPC) MAAL_C PF07476.11 ETO23689.1 - 0.036 13.2 0.1 0.052 12.7 0.1 1.2 1 0 0 1 1 1 0 Methylaspartate ammonia-lyase C-terminus K_trans PF02705.16 ETO23690.1 - 0.14 10.7 3.7 0.19 10.2 3.7 1.2 1 0 0 1 1 1 0 K+ potassium transporter Neur_chan_memb PF02932.16 ETO23690.1 - 0.16 12.0 7.1 0.23 11.5 7.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO23690.1 - 3.1 6.5 6.0 3.7 6.2 6.0 1.1 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 ETO23690.1 - 6 5.5 24.0 2.6 6.7 14.4 2.5 1 1 1 2 2 2 0 O-antigen ligase like membrane protein RIFIN PF02009.16 ETO23691.1 - 0.017 15.0 1.1 0.017 15.0 1.1 3.9 3 1 2 5 5 5 0 Rifin DUF2615 PF11027.8 ETO23691.1 - 0.25 11.5 0.0 0.25 11.5 0.0 4.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) SNARE PF05739.19 ETO23691.1 - 0.8 9.7 4.3 2.4 8.2 4.3 1.8 1 0 0 1 1 1 0 SNARE domain Pkinase PF00069.25 ETO23692.1 - 9.4e-49 166.1 1.1 2.1e-48 165.0 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23692.1 - 2.8e-24 85.8 0.0 5.4e-24 84.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Myosin_TH1 PF06017.13 ETO23692.1 - 2.4e-17 63.2 6.8 2.4e-17 63.2 6.8 1.7 2 0 0 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding Pkinase_C PF00433.24 ETO23692.1 - 0.00026 21.6 4.8 0.00035 21.2 2.0 2.3 2 0 0 2 2 2 1 Protein kinase C terminal domain Kinase-like PF14531.6 ETO23692.1 - 0.00047 19.6 0.1 0.0013 18.1 0.0 1.8 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ETO23692.1 - 0.00078 18.9 0.0 0.0017 17.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family hSac2 PF12456.8 ETO23692.1 - 0.0097 15.6 0.0 0.033 13.9 0.0 2.0 1 0 0 1 1 1 1 Inositol phosphatase DUF4106 PF13388.6 ETO23692.1 - 0.48 9.6 7.2 0.056 12.7 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4106) PH PF00169.29 ETO23693.1 - 1.5e-10 41.6 0.9 8.2e-10 39.1 0.9 2.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO23693.1 - 8.7e-05 22.7 0.1 0.00032 20.9 0.1 2.0 1 0 0 1 1 1 1 Pleckstrin homology domain PH_9 PF15410.6 ETO23693.1 - 0.00024 21.5 1.0 0.0041 17.5 0.6 3.3 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 ETO23693.1 - 0.00068 19.5 3.3 0.0031 17.3 3.3 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 ETO23693.1 - 0.0043 17.4 1.4 0.014 15.7 1.4 2.0 1 0 0 1 1 1 1 Plant pleckstrin homology-like region WD40 PF00400.32 ETO23693.1 - 0.14 13.1 0.2 2.7 9.0 0.0 2.9 2 0 0 2 2 2 0 WD domain, G-beta repeat SSP160 PF06933.11 ETO23693.1 - 0.17 10.1 4.9 0.26 9.4 4.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PH_3 PF14593.6 ETO23693.1 - 0.26 11.4 5.0 0.11 12.6 1.6 2.2 2 0 0 2 2 2 0 PH domain PH_11 PF15413.6 ETO23693.1 - 1.2 9.6 8.1 1.1 9.7 2.9 3.4 2 1 0 2 2 2 0 Pleckstrin homology domain BRCT PF00533.26 ETO23694.1 - 0.00083 19.7 0.1 0.46 10.9 0.1 2.6 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain BRCT_3 PF18428.1 ETO23694.1 - 0.00086 19.3 0.0 0.0028 17.7 0.0 1.8 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain GTP-bdg_N PF13167.6 ETO23694.1 - 0.13 12.9 0.8 0.38 11.5 0.0 2.1 3 0 0 3 3 3 0 GTP-binding GTPase N-terminal DAGK_acc PF00609.19 ETO23696.1 - 1e-10 42.2 0.1 1.8e-10 41.3 0.1 1.4 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain ARID PF01388.21 ETO23697.1 - 0.0093 16.6 0.1 0.037 14.7 0.0 1.9 2 0 0 2 2 2 1 ARID/BRIGHT DNA binding domain Peptidase_S46 PF10459.9 ETO23697.1 - 0.046 12.4 10.4 0.053 12.2 10.4 1.1 1 0 0 1 1 1 0 Peptidase S46 IL2 PF00715.17 ETO23697.1 - 0.38 10.7 7.0 1.6 8.6 0.9 2.4 2 1 0 2 2 2 0 Interleukin 2 FliD_N PF02465.18 ETO23697.1 - 2.8 8.7 9.8 7.7 7.3 1.3 2.4 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus HIP1_clath_bdg PF16515.5 ETO23697.1 - 7.9 7.2 18.5 0.61 10.7 4.1 2.3 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 SWI-SNF_Ssr4 PF08549.10 ETO23698.1 - 0.12 11.0 9.6 0.14 10.8 9.6 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) SDA1 PF05285.12 ETO23698.1 - 0.15 11.5 15.4 0.16 11.4 15.4 1.0 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 ETO23698.1 - 2.2 7.0 10.7 2.3 6.9 10.7 1.0 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO23698.1 - 2.5 7.0 8.8 2.6 7.0 8.8 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4661 PF15576.6 ETO23698.1 - 7.3 6.4 8.6 8.4 6.2 8.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Zip PF02535.22 ETO23698.1 - 9.7 5.3 9.3 11 5.1 9.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Q_salvage PF10343.9 ETO23699.1 - 4.2e-78 262.8 0.8 6.9e-78 262.1 0.8 1.4 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family Dynamitin PF04912.14 ETO23700.1 - 2.6e-08 33.6 7.7 3.1e-08 33.4 7.7 1.1 1 0 0 1 1 1 1 Dynamitin EMP24_GP25L PF01105.24 ETO23700.1 - 0.0096 15.9 0.7 0.017 15.1 0.7 1.3 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF4407 PF14362.6 ETO23701.1 - 0.012 15.0 5.0 0.03 13.7 5.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) ABC_tran_CTD PF16326.5 ETO23701.1 - 0.082 13.2 0.2 0.082 13.2 0.2 3.3 3 1 0 3 3 3 0 ABC transporter C-terminal domain RP-C_C PF11800.8 ETO23701.1 - 0.59 10.2 5.8 0.26 11.3 1.2 2.0 2 0 0 2 2 2 0 Replication protein C C-terminal region Snf7 PF03357.21 ETO23701.1 - 0.76 9.4 10.5 0.13 11.8 4.1 2.2 2 0 0 2 2 2 0 Snf7 SlyX PF04102.12 ETO23701.1 - 0.88 10.2 12.8 0.4 11.3 2.2 3.1 3 0 0 3 3 3 0 SlyX DUF4665 PF15679.5 ETO23701.1 - 0.94 10.1 7.4 3.5 8.3 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4665) CCDC-167 PF15188.6 ETO23701.1 - 2.1 8.8 8.9 0.54 10.6 1.5 2.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 167 Uso1_p115_C PF04871.13 ETO23701.1 - 2.2 8.7 11.7 2 8.8 4.0 2.2 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region Cnn_1N PF07989.11 ETO23701.1 - 6.5 7.0 17.2 4.6 7.5 0.4 3.2 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 GAT PF03127.14 ETO23701.1 - 7.4 7.0 11.1 7.1 7.0 4.4 3.3 2 1 2 4 4 4 0 GAT domain CdvA PF18822.1 ETO23701.1 - 7.4 6.4 10.9 8.2 6.3 0.8 2.7 2 2 0 2 2 2 0 CdvA-like coiled-coil domain DUF3552 PF12072.8 ETO23701.1 - 8.5 5.7 14.2 0.05 13.0 1.4 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3552) DUF3860 PF12976.7 ETO23702.1 - 0.01 15.8 0.1 0.033 14.2 0.1 1.9 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3860) DUF4576 PF15144.6 ETO23703.1 - 0.002 18.0 0.0 0.15 12.0 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4576) AI-2E_transport PF01594.16 ETO23703.1 - 0.0091 15.2 0.0 0.011 14.9 0.0 1.1 1 0 0 1 1 1 1 AI-2E family transporter Kelch_1 PF01344.25 ETO23704.1 - 9e-10 38.0 1.1 0.00083 18.9 0.2 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_5 PF13854.6 ETO23704.1 - 1.3e-07 31.4 2.4 0.00057 19.8 0.1 4.6 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO23704.1 - 1.2e-05 25.3 2.0 0.17 12.2 0.0 4.0 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO23704.1 - 1.8e-05 24.5 3.0 0.086 12.9 0.2 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO23704.1 - 0.00051 20.3 0.2 0.013 15.8 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO23704.1 - 0.00058 19.8 0.2 0.78 9.8 0.0 4.1 4 0 0 4 4 4 1 Galactose oxidase, central domain HEAT PF02985.22 ETO23705.1 - 3.6e-06 26.8 3.9 0.001 19.2 0.1 3.7 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ETO23705.1 - 0.0027 18.2 0.1 0.47 11.0 0.0 3.8 3 1 1 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 ETO23705.1 - 0.0029 17.6 0.0 0.081 13.0 0.0 2.8 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETO23705.1 - 0.029 12.9 0.0 0.29 9.7 0.0 2.1 1 1 0 1 1 1 0 Adaptin N terminal region Xpo1 PF08389.12 ETO23705.1 - 0.038 14.0 0.4 18 5.3 0.0 3.6 2 1 1 3 3 3 0 Exportin 1-like protein TFCD_C PF12612.8 ETO23705.1 - 0.095 12.5 0.1 0.6 9.9 0.0 2.3 2 1 1 3 3 3 0 Tubulin folding cofactor D C terminal DUF445 PF04286.12 ETO23705.1 - 0.18 11.5 0.2 13 5.5 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF445) P16-Arc PF04699.14 ETO23706.1 - 1.9e-15 57.7 0.1 2.4e-15 57.3 0.1 1.1 1 0 0 1 1 1 1 ARP2/3 complex 16 kDa subunit (p16-Arc) Utp12 PF04003.12 ETO23706.1 - 0.0097 16.2 0.0 0.025 14.9 0.0 1.6 2 0 0 2 2 2 1 Dip2/Utp12 Family His_kinase PF06580.13 ETO23706.1 - 0.23 11.8 0.8 11 6.5 0.1 2.6 2 1 1 3 3 3 0 Histidine kinase WD40 PF00400.32 ETO23709.1 - 7.6e-67 219.6 20.9 2e-10 41.1 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23709.1 - 7.2e-22 77.5 1.5 0.013 15.8 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23709.1 - 6.4e-18 64.8 2.9 0.11 11.4 0.0 7.1 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO23709.1 - 1.8e-13 50.8 0.1 0.00036 20.5 0.1 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO23709.1 - 3.1e-08 33.3 7.6 7.6 6.6 0.1 7.0 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO23709.1 - 2.9e-06 26.8 1.8 0.008 15.5 0.0 3.7 2 1 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 ETO23709.1 - 7.8e-05 21.5 4.4 0.09 11.4 0.1 4.3 2 2 3 5 5 5 1 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO23709.1 - 0.002 17.0 0.0 0.92 8.2 0.0 3.5 3 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cytochrom_D1 PF02239.16 ETO23709.1 - 0.0029 16.2 0.2 1.1 7.7 0.0 3.2 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO23709.1 - 0.0034 16.2 4.9 0.8 8.4 0.1 3.8 2 2 1 3 3 3 2 Nup133 N terminal like Nbas_N PF15492.6 ETO23709.1 - 0.0037 16.6 1.0 4.4 6.5 0.0 3.5 1 1 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO23709.1 - 0.005 16.5 6.1 28 4.5 0.1 5.4 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Surfac_D-trimer PF09006.11 ETO23709.1 - 0.48 10.3 1.5 20 5.1 0.0 4.0 6 0 0 6 6 6 0 Lung surfactant protein D coiled-coil trimerisation DUF4745 PF15923.5 ETO23710.1 - 0.027 14.4 3.1 0.035 14.1 0.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4745) GluR_Homer-bdg PF10606.9 ETO23710.1 - 0.2 11.9 1.2 0.6 10.4 0.7 1.9 2 0 0 2 2 2 0 Homer-binding domain of metabotropic glutamate receptor SAM_1 PF00536.30 ETO23711.1 - 6.6e-12 45.7 0.4 1.9e-11 44.2 0.2 2.0 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO23711.1 - 1.3e-10 41.2 0.2 4.7e-10 39.4 0.2 2.0 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Prominin PF05478.11 ETO23711.1 - 0.001 17.1 15.0 0.001 17.1 15.0 1.8 2 0 0 2 2 2 1 Prominin HMMR_N PF15905.5 ETO23711.1 - 0.0085 15.6 34.3 0.0085 15.6 34.3 2.9 2 1 0 3 3 3 1 Hyaluronan mediated motility receptor N-terminal CC2-LZ PF16516.5 ETO23711.1 - 0.025 14.9 4.6 0.025 14.9 4.6 5.2 3 1 2 5 5 5 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator LMBR1 PF04791.16 ETO23711.1 - 0.24 10.3 16.1 0.42 9.5 16.1 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein T2SSM PF04612.12 ETO23711.1 - 0.32 11.1 9.9 0.15 12.1 3.7 2.8 1 1 2 3 3 3 0 Type II secretion system (T2SS), protein M ATG16 PF08614.11 ETO23711.1 - 0.37 11.0 45.6 1.5 9.0 0.2 3.9 3 1 1 4 4 4 0 Autophagy protein 16 (ATG16) Terminase_6 PF03237.15 ETO23711.1 - 0.37 10.4 3.3 0.35 10.5 0.9 2.1 2 1 0 2 2 2 0 Terminase-like family T7SS_ESX_EspC PF10824.8 ETO23711.1 - 0.59 10.6 4.3 14 6.3 0.4 3.7 2 1 2 4 4 4 0 Excreted virulence factor EspC, type VII ESX diderm dCache_1 PF02743.18 ETO23711.1 - 1.2 8.8 6.1 0.49 10.1 3.6 1.7 2 0 0 2 2 2 0 Cache domain MAD PF05557.13 ETO23711.1 - 2.7 6.2 43.9 1.9 6.7 33.5 2.6 3 0 0 3 3 3 0 Mitotic checkpoint protein ZYG-11_interact PF05884.12 ETO23711.1 - 4.5 6.6 8.5 1.6 8.1 5.7 1.8 2 0 0 2 2 2 0 Interactor of ZYG-11 ApoO PF09769.9 ETO23711.1 - 4.7 7.2 8.6 1.6 8.7 3.8 2.6 1 1 2 3 3 3 0 Apolipoprotein O FUSC PF04632.12 ETO23711.1 - 5.3 5.5 5.3 7.8 4.9 5.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein family EzrA PF06160.12 ETO23711.1 - 5.9 4.9 39.7 0.013 13.7 25.6 2.9 2 1 0 3 3 3 0 Septation ring formation regulator, EzrA 60KD_IMP PF02096.20 ETO23711.1 - 7.5 6.4 8.8 0.92 9.4 0.2 2.8 1 1 2 3 3 3 0 60Kd inner membrane protein ERM PF00769.19 ETO23711.1 - 8 6.2 47.3 16 5.2 44.7 2.2 1 1 1 2 2 2 0 Ezrin/radixin/moesin family DUF4404 PF14357.6 ETO23711.1 - 9.5 6.9 44.2 0.27 11.9 12.5 5.2 4 1 3 7 7 6 0 Domain of unknown function (DUF4404) SAM_1 PF00536.30 ETO23712.1 - 4e-13 49.6 0.2 7.3e-13 48.8 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO23712.1 - 4e-09 36.4 0.1 7e-09 35.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3810 PF12725.7 ETO23712.1 - 0.0045 16.4 0.4 0.027 13.8 0.6 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3810) OmpH PF03938.14 ETO23712.1 - 0.019 15.3 8.6 0.03 14.7 8.6 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Atg14 PF10186.9 ETO23712.1 - 0.21 10.6 10.6 0.078 12.1 8.1 1.4 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Cob_adeno_trans PF01923.18 ETO23712.1 - 0.23 11.6 2.1 0.35 11.0 2.1 1.3 1 0 0 1 1 1 0 Cobalamin adenosyltransferase HalX PF08663.10 ETO23712.1 - 0.53 10.6 9.0 1.2 9.6 2.5 2.4 1 1 1 2 2 2 0 HalX domain BRE1 PF08647.11 ETO23712.1 - 0.56 10.3 12.6 4.6 7.4 4.5 2.3 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase ZapB PF06005.12 ETO23713.1 - 0.025 15.0 0.6 0.076 13.5 0.6 1.8 1 0 0 1 1 1 0 Cell division protein ZapB PTR2 PF00854.21 ETO23716.1 - 3.2e-41 141.5 1.8 3.2e-41 141.5 1.8 1.3 2 0 0 2 2 2 1 POT family DUF872 PF05915.12 ETO23716.1 - 0.23 11.6 5.6 3.2 8.0 1.0 2.7 2 1 0 2 2 2 0 Eukaryotic protein of unknown function (DUF872) MDD_C PF18376.1 ETO23717.1 - 5.9e-35 120.7 0.0 7e-35 120.5 0.0 1.1 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain dNK PF01712.19 ETO23718.1 - 4.5e-37 127.9 1.3 2e-34 119.2 1.3 2.1 1 1 0 1 1 1 1 Deoxynucleoside kinase AAA_33 PF13671.6 ETO23718.1 - 0.00069 19.8 0.1 0.0062 16.7 0.1 2.2 1 1 0 1 1 1 1 AAA domain Thymidylate_kin PF02223.17 ETO23718.1 - 0.0038 16.9 0.1 0.12 12.0 0.2 2.6 2 1 0 2 2 2 1 Thymidylate kinase AAA_18 PF13238.6 ETO23718.1 - 0.011 16.3 0.0 0.41 11.2 0.0 2.3 1 1 0 1 1 1 0 AAA domain DUF4834 PF16118.5 ETO23719.1 - 0.00047 21.1 3.4 0.00047 21.1 3.4 4.6 2 2 1 3 3 3 1 Domain of unknown function (DUF4834) V_ATPase_I PF01496.19 ETO23719.1 - 2.1 6.1 10.9 0.14 10.0 1.2 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ETO23719.1 - 4.6 5.4 18.5 0.094 11.0 10.4 2.0 2 0 0 2 2 2 0 CDC45-like protein EIIBC-GUT_N PF03612.14 ETO23719.1 - 7.5 6.3 7.0 2.4 7.9 3.0 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus UBM PF14377.6 ETO23721.1 - 3.5e-05 23.1 0.9 3.5e-05 23.1 0.9 2.6 3 0 0 3 3 3 1 Ubiquitin binding region Pex14_N PF04695.13 ETO23721.1 - 0.028 15.1 5.7 0.032 14.9 5.7 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 ETO23721.1 - 4.3 7.2 14.3 4.9 7.0 14.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RNA_pol_Rbc25 PF08292.12 ETO23722.1 - 0.1 12.8 2.5 0.19 11.9 2.5 1.5 1 0 0 1 1 1 0 RNA polymerase III subunit Rpc25 OmpH PF03938.14 ETO23722.1 - 1.3 9.4 5.9 2.1 8.7 5.9 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) SAP PF02037.27 ETO23723.1 - 1.3e-08 34.4 5.7 2.8e-08 33.3 5.7 1.6 1 0 0 1 1 1 1 SAP domain Trypan_PARP PF05887.11 ETO23724.1 - 0.15 12.0 37.6 0.1 12.6 36.1 1.6 1 1 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4551 PF15087.6 ETO23724.1 - 0.35 9.6 6.1 0.4 9.5 6.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) DUF2868 PF11067.8 ETO23724.1 - 0.6 9.6 1.3 0.61 9.5 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) ADIP PF11559.8 ETO23725.1 - 0.0093 16.1 4.1 0.0093 16.1 4.1 2.2 2 0 0 2 2 2 1 Afadin- and alpha -actinin-Binding GBP_C PF02841.14 ETO23725.1 - 0.011 15.1 21.0 0.017 14.6 21.0 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Presenilin PF01080.17 ETO23725.1 - 0.49 9.1 10.4 0.7 8.6 10.4 1.2 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ETO23725.1 - 1.5 8.5 10.6 0.29 10.8 5.6 2.0 2 0 0 2 2 2 0 FAM176 family Trypan_PARP PF05887.11 ETO23725.1 - 1.7 8.6 7.0 2.8 7.9 7.0 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF5308 PF17233.2 ETO23725.1 - 2.4 8.4 5.8 1.7 8.9 2.0 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5308) Atrophin-1 PF03154.15 ETO23725.1 - 4.9 5.3 28.1 0.029 12.7 19.3 1.6 2 0 0 2 2 2 0 Atrophin-1 family GRP PF07172.11 ETO23725.1 - 7.9 7.2 9.7 36 5.1 6.5 2.8 2 1 0 2 2 2 0 Glycine rich protein family DUF4472 PF14739.6 ETO23726.1 - 6.5e-05 23.6 5.3 0.0011 19.6 2.2 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4472) DUF3645 PF12359.8 ETO23726.1 - 0.034 13.5 0.2 0.059 12.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3645) Cep57_CLD_2 PF14197.6 ETO23726.1 - 0.26 11.4 10.1 4.6 7.4 0.1 3.1 2 1 1 3 3 3 0 Centrosome localisation domain of PPC89 Mem_trans PF03547.18 ETO23727.1 - 0.059 11.7 0.0 0.068 11.6 0.0 1.0 1 0 0 1 1 1 0 Membrane transport protein TRAP_alpha PF03896.16 ETO23727.1 - 0.074 12.2 3.0 0.072 12.3 3.0 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO23727.1 - 0.13 10.4 11.1 0.13 10.3 11.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi BNIP2 PF12496.8 ETO23727.1 - 0.14 12.6 3.3 0.14 12.6 3.3 1.1 1 0 0 1 1 1 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 YL1 PF05764.13 ETO23727.1 - 0.24 11.5 8.4 0.24 11.5 8.4 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 ETO23727.1 - 0.97 7.6 8.5 0.93 7.6 8.5 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO23727.1 - 1.9 7.8 11.8 2.3 7.6 11.8 1.1 1 0 0 1 1 1 0 SDA1 Importin_rep_2 PF18786.1 ETO23728.1 - 0.069 13.0 0.4 0.23 11.3 0.1 2.0 2 0 0 2 2 2 0 Importin 13 repeat zf-RanBP PF00641.18 ETO23728.1 - 0.11 11.8 2.9 0.22 10.9 2.9 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DUF641 PF04859.12 ETO23728.1 - 0.9 9.9 12.9 1.4 9.2 1.0 3.5 3 0 0 3 3 3 0 Plant protein of unknown function (DUF641) Ribosomal_S8 PF00410.19 ETO23728.1 - 0.99 9.4 5.8 0.26 11.2 0.9 2.7 2 1 0 2 2 2 0 Ribosomal protein S8 Cytochrome_C554 PF13435.6 ETO23729.1 - 0.48 11.4 5.0 0.15 13.0 0.6 2.4 3 0 0 3 3 3 0 Cytochrome c554 and c-prime ORC3_N PF07034.11 ETO23732.1 - 1.2 8.1 6.9 1.4 7.9 0.1 2.2 2 0 0 2 2 2 0 Origin recognition complex (ORC) subunit 3 N-terminus vATP-synt_E PF01991.18 ETO23733.1 - 2.9e-16 59.5 0.4 3.4e-16 59.3 0.4 1.0 1 0 0 1 1 1 1 ATP synthase (E/31 kDa) subunit OSCP PF00213.18 ETO23733.1 - 0.006 16.7 0.2 0.0074 16.4 0.2 1.2 1 0 0 1 1 1 1 ATP synthase delta (OSCP) subunit Pkinase PF00069.25 ETO23735.1 - 1.8e-41 142.3 0.6 2.9e-41 141.6 0.6 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23735.1 - 1.4e-24 86.8 0.2 2.1e-24 86.2 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO23735.1 - 0.00026 21.0 0.2 0.08 12.8 0.1 2.3 1 1 1 2 2 2 2 Phosphotransferase enzyme family 7TMR-HDED PF07697.11 ETO23735.1 - 0.0058 16.8 1.7 0.0083 16.3 1.7 1.2 1 0 0 1 1 1 1 7TM-HD extracellular FTA2 PF13095.6 ETO23735.1 - 0.092 12.4 1.7 0.66 9.6 0.0 2.5 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 Pkinase_fungal PF17667.1 ETO23735.1 - 0.2 10.4 3.7 3.4 6.3 3.7 2.1 1 1 0 1 1 1 0 Fungal protein kinase TBD PF12845.7 ETO23735.1 - 6.7 6.7 6.5 13 5.8 3.7 2.6 2 1 0 2 2 2 0 TBD domain zf-C2H2 PF00096.26 ETO23736.1 - 5.7e-12 45.4 21.2 1.8e-05 24.9 0.6 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO23736.1 - 6.8e-11 42.1 10.6 9.8e-08 32.1 1.4 3.6 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO23736.1 - 7e-11 42.0 17.9 0.0019 18.9 0.2 3.6 3 0 0 3 3 3 3 C2H2-type zinc finger DUF4187 PF13821.6 ETO23736.1 - 0.00033 20.4 1.2 0.00033 20.4 1.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4187) zf-met PF12874.7 ETO23736.1 - 0.0028 18.0 15.1 0.25 11.8 0.1 3.9 4 0 0 4 4 4 2 Zinc-finger of C2H2 type zf-C2H2_11 PF16622.5 ETO23736.1 - 0.0031 17.2 9.1 3.8 7.4 0.2 3.4 3 0 0 3 3 3 3 zinc-finger C2H2-type zf-H2C2_5 PF13909.6 ETO23736.1 - 0.041 13.6 2.2 0.041 13.6 2.2 3.6 4 0 0 4 4 3 0 C2H2-type zinc-finger domain zf-BED PF02892.15 ETO23736.1 - 0.11 12.5 13.5 0.56 10.3 1.6 3.6 3 1 1 4 4 3 0 BED zinc finger zf-C2HE PF16278.5 ETO23736.1 - 0.11 12.9 7.2 7.2 7.1 0.0 3.6 2 1 1 3 3 3 0 C2HE / C2H2 / C2HC zinc-binding finger zf_C2H2_13 PF18508.1 ETO23736.1 - 0.21 11.2 2.8 2.4 7.8 0.2 2.9 3 0 0 3 3 3 0 Zinc finger domain zf-C2H2_8 PF15909.5 ETO23736.1 - 0.4 11.0 6.7 1.7 9.0 4.4 2.7 2 1 1 3 3 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ETO23736.1 - 0.44 10.9 15.6 0.54 10.6 0.2 4.2 4 0 0 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2HC_2 PF13913.6 ETO23736.1 - 0.6 10.1 0.0 0.6 10.1 0.0 2.7 2 0 0 2 2 2 0 zinc-finger of a C2HC-type XPA_N PF01286.18 ETO23736.1 - 0.82 9.8 3.9 19 5.4 0.0 2.6 2 0 0 2 2 2 0 XPA protein N-terminal Zn-ribbon_8 PF09723.10 ETO23736.1 - 2.5 8.3 5.6 23 5.2 0.3 2.8 2 1 0 2 2 2 0 Zinc ribbon domain zf-C2H2_6 PF13912.6 ETO23736.1 - 3.4 7.8 14.5 3.1 7.9 0.2 3.5 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2_2 PF12756.7 ETO23736.1 - 3.6 8.0 13.4 6.6 7.1 0.7 3.6 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) HECT PF00632.25 ETO23737.1 - 6.9e-67 226.1 0.0 2.8e-64 217.5 0.0 2.3 2 1 0 2 2 2 2 HECT-domain (ubiquitin-transferase) UCH PF00443.29 ETO23737.1 - 0.042 13.3 0.2 0.07 12.6 0.2 1.5 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase FmdE PF02663.14 ETO23737.1 - 0.68 10.0 2.2 1.6 8.8 2.2 1.6 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Ndc1_Nup PF09531.10 ETO23737.1 - 0.7 8.5 7.0 1.1 7.9 7.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MFA1_2 PF17317.2 ETO23737.1 - 2.1 8.2 7.0 1.4 8.7 0.2 3.6 3 0 0 3 3 3 0 Mating hormone A-factor 1&2 PX PF00787.24 ETO23738.1 - 6e-08 32.7 1.1 1e-07 31.9 1.1 1.4 1 0 0 1 1 1 1 PX domain DNA_pol_E_B PF04042.16 ETO23739.1 - 3e-43 147.6 1.5 5e-43 146.9 1.5 1.4 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Dpoe2NT PF12213.8 ETO23739.1 - 0.00078 19.7 0.0 0.0023 18.2 0.0 1.8 1 0 0 1 1 1 1 DNA polymerases epsilon N terminal Membralin PF09746.9 ETO23740.1 - 2.9 6.8 9.0 3.9 6.4 9.0 1.1 1 0 0 1 1 1 0 Tumour-associated protein START PF01852.19 ETO23741.1 - 8.4e-16 58.0 0.3 5.5e-12 45.5 0.1 2.5 2 0 0 2 2 2 2 START domain CFIA_Pcf11 PF11526.8 ETO23741.1 - 0.32 11.5 30.8 0.059 13.9 12.3 3.2 3 0 0 3 3 3 0 Subunit of cleavage factor IA Pcf11 SpoIIIAH PF12685.7 ETO23741.1 - 1 9.1 22.0 0.98 9.2 2.6 3.0 3 0 0 3 3 3 0 SpoIIIAH-like protein FAM176 PF14851.6 ETO23741.1 - 1.4 8.6 22.5 8.9 6.0 11.4 3.3 3 0 0 3 3 3 0 FAM176 family Secretin_N_2 PF07655.13 ETO23741.1 - 2.6 8.7 21.0 1.8 9.2 16.3 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3408 PF11888.8 ETO23741.1 - 3.6 7.7 28.4 1.1 9.3 0.8 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3408) CPSF100_C PF13299.6 ETO23741.1 - 6.6 6.9 22.8 6.7 6.9 0.6 3.2 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal DUF719 PF05334.13 ETO23741.1 - 8.1 6.6 20.8 7.9 6.6 0.9 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF719) START PF01852.19 ETO23742.1 - 6.6e-07 28.9 0.0 9.7e-07 28.4 0.0 1.4 1 0 0 1 1 1 1 START domain RCC1 PF00415.18 ETO23744.1 - 9.9e-11 42.1 0.4 0.00042 20.9 0.0 2.3 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO23744.1 - 8.9e-06 25.4 0.3 0.075 12.9 0.2 2.5 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat DFRP_C PF16543.5 ETO23744.1 - 3.4 8.2 7.2 0.81 10.2 0.5 2.3 2 0 0 2 2 2 0 DRG Family Regulatory Proteins, Tma46 EIIBC-GUT_N PF03612.14 ETO23747.1 - 3.7 7.3 10.9 4.3 7.0 10.5 1.4 1 1 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Paramyxo_ncap PF00973.19 ETO23747.1 - 7.4 5.4 10.2 8 5.3 10.2 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein FMO-like PF00743.19 ETO23748.1 - 2.6e-12 46.0 0.2 1.4e-11 43.6 0.2 1.9 1 1 0 1 1 1 1 Flavin-binding monooxygenase-like Pyr_redox_3 PF13738.6 ETO23748.1 - 2.7e-11 43.3 1.6 6e-05 22.4 0.5 3.6 2 1 1 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO23748.1 - 2.4e-09 36.8 0.8 3.3e-09 36.3 0.1 1.5 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 ETO23748.1 - 4.6e-07 29.4 0.1 1.3e-06 27.8 0.1 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETO23748.1 - 0.0014 18.7 1.4 3.5 7.6 0.1 3.3 2 1 1 3 3 3 1 FAD-NAD(P)-binding Amino_oxidase PF01593.24 ETO23748.1 - 0.0018 17.6 0.0 0.0035 16.7 0.0 1.4 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox PF00070.27 ETO23748.1 - 0.0019 18.7 2.4 3.6 8.2 0.0 3.4 3 0 0 3 3 3 2 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETO23748.1 - 2 7.9 3.3 16 5.0 0.8 2.4 1 1 0 2 2 2 0 FAD dependent oxidoreductase Alpha-E PF04168.12 ETO23749.1 - 0.1 12.4 0.1 0.26 11.0 0.0 1.7 2 0 0 2 2 2 0 A predicted alpha-helical domain with a conserved ER motif. DsrD PF08679.11 ETO23749.1 - 3 8.2 0.0 3 8.2 0.0 3.6 4 0 0 4 4 4 0 Dissimilatory sulfite reductase D (DsrD) Hat1_N PF10394.9 ETO23751.1 - 1.4e-07 31.9 0.1 2.5e-07 31.1 0.1 1.4 1 0 0 1 1 1 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 ETO23751.1 - 0.00069 19.8 0.0 0.00093 19.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 ETO23751.1 - 0.0049 16.5 0.3 0.0069 16.1 0.3 1.2 1 0 0 1 1 1 1 MOZ/SAS family Acetyltransf_7 PF13508.7 ETO23751.1 - 0.18 12.3 0.9 0.32 11.4 0.0 1.8 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain DUF3677 PF12432.8 ETO23752.1 - 0.041 14.2 0.2 0.21 11.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3677) Cyclin_N PF00134.23 ETO23753.1 - 9.6e-32 109.4 1.2 2e-31 108.4 1.2 1.6 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO23753.1 - 1.9e-20 73.1 0.3 3.1e-20 72.4 0.3 1.4 1 0 0 1 1 1 1 Cyclin, C-terminal domain Presenilin PF01080.17 ETO23754.1 - 0.0013 17.5 16.5 0.0016 17.3 16.5 1.1 1 0 0 1 1 1 1 Presenilin Utp14 PF04615.13 ETO23754.1 - 0.0068 15.1 13.4 0.0071 15.0 13.4 1.1 1 0 0 1 1 1 1 Utp14 protein Macoilin PF09726.9 ETO23754.1 - 0.019 13.6 15.8 0.018 13.7 15.8 1.1 1 0 0 1 1 1 0 Macoilin family Gti1_Pac2 PF09729.9 ETO23754.1 - 0.29 11.2 17.7 0.56 10.3 17.7 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family Hamartin PF04388.12 ETO23754.1 - 0.55 8.8 13.6 0.67 8.5 13.6 1.1 1 0 0 1 1 1 0 Hamartin protein SLC12 PF03522.15 ETO23754.1 - 0.84 8.6 18.3 1 8.3 18.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF3527 PF12043.8 ETO23754.1 - 2.6 7.5 14.3 3.5 7.1 14.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) NPR3 PF03666.13 ETO23754.1 - 2.9 6.6 23.5 3.8 6.2 23.5 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO23754.1 - 3.1 6.9 13.4 4.6 6.3 13.4 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3807 PF12720.7 ETO23754.1 - 3.3 7.9 20.3 5.3 7.3 20.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Sec62 PF03839.16 ETO23754.1 - 3.5 7.1 9.0 5.6 6.4 9.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Raftlin PF15250.6 ETO23754.1 - 5 5.7 14.8 6.3 5.4 14.8 1.1 1 0 0 1 1 1 0 Raftlin Dapper PF15268.6 ETO23754.1 - 8.1 5.2 16.2 9.9 4.9 16.2 1.1 1 0 0 1 1 1 0 Dapper PNISR PF15996.5 ETO23754.1 - 8.5 6.6 20.2 12 6.1 20.2 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR FAM60A PF15396.6 ETO23754.1 - 8.8 6.3 21.5 15 5.5 20.7 1.7 1 1 1 2 2 2 0 Protein Family FAM60A Rtf2 PF04641.12 ETO23754.1 - 9.5 5.5 23.1 12 5.2 22.6 1.4 1 1 0 1 1 1 0 Rtf2 RING-finger Striatin PF08232.12 ETO23756.1 - 0.00093 19.8 1.7 0.0014 19.2 1.7 1.3 1 0 0 1 1 1 1 Striatin family bZIP_1 PF00170.21 ETO23756.1 - 0.03 14.4 2.7 0.097 12.8 2.7 1.8 1 0 0 1 1 1 0 bZIP transcription factor AATF-Che1 PF13339.6 ETO23756.1 - 0.042 14.5 6.4 0.038 14.7 4.5 1.8 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor PriC PF07445.12 ETO23756.1 - 0.047 13.6 4.2 0.083 12.8 4.2 1.3 1 0 0 1 1 1 0 Primosomal replication protein priC DUF789 PF05623.12 ETO23756.1 - 0.05 13.3 2.1 0.094 12.4 2.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF789) SNAPc19 PF15497.6 ETO23756.1 - 0.12 12.9 7.5 0.25 11.8 7.5 1.5 1 0 0 1 1 1 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 V_ATPase_I PF01496.19 ETO23756.1 - 0.19 9.6 2.1 0.25 9.2 2.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family YabA PF06156.13 ETO23756.1 - 0.54 10.9 4.7 0.37 11.5 2.1 2.0 2 0 0 2 2 2 0 Initiation control protein YabA DivIC PF04977.15 ETO23756.1 - 0.76 9.6 5.1 1.1 9.0 0.5 2.4 2 0 0 2 2 2 0 Septum formation initiator Uso1_p115_C PF04871.13 ETO23756.1 - 0.78 10.1 11.4 1.4 9.3 11.4 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region ZapB PF06005.12 ETO23756.1 - 4.3 7.9 8.3 0.63 10.5 0.2 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DUF3086 PF11285.8 ETO23757.1 - 0.24 10.4 5.6 0.38 9.8 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3086) Tyrosinase PF00264.20 ETO23759.1 - 4.9e-22 79.3 1.4 9.1e-22 78.4 1.4 1.5 1 0 0 1 1 1 1 Common central domain of tyrosinase Haemocyan_bet_s PF14830.6 ETO23759.1 - 1.2e-06 28.4 0.0 3.8e-06 26.8 0.0 1.9 2 0 0 2 2 2 1 Haemocyanin beta-sandwich Spc7 PF08317.11 ETO23760.1 - 0.0053 15.7 18.5 0.0053 15.7 18.5 2.0 1 1 1 2 2 2 1 Spc7 kinetochore protein TPR_MLP1_2 PF07926.12 ETO23760.1 - 0.0058 16.7 19.5 0.0058 16.7 19.5 2.2 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein GAS PF13851.6 ETO23760.1 - 0.016 14.6 1.5 0.016 14.6 1.5 3.0 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Tropomyosin_1 PF12718.7 ETO23760.1 - 0.1 12.7 26.5 0.029 14.5 19.3 2.3 2 0 0 2 2 2 0 Tropomyosin like DUF4407 PF14362.6 ETO23760.1 - 0.4 10.0 14.1 0.14 11.5 7.0 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 ETO23760.1 - 0.63 10.1 27.7 1.2 9.1 17.5 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF4201 PF13870.6 ETO23760.1 - 0.69 9.6 25.2 1.6 8.4 10.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4201) Golgin_A5 PF09787.9 ETO23760.1 - 0.85 9.0 27.0 1.1 8.7 13.3 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 PRKG1_interact PF15898.5 ETO23760.1 - 4.3 8.3 27.6 1.9 9.4 8.3 2.8 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Cob_adeno_trans PF01923.18 ETO23760.1 - 8.6 6.5 8.0 20 5.3 0.7 2.4 1 1 1 2 2 2 0 Cobalamin adenosyltransferase TPR_2 PF07719.17 ETO23761.1 - 0.00064 19.6 2.0 1.1 9.5 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO23761.1 - 0.00068 19.8 0.3 0.0026 18.0 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO23761.1 - 0.021 15.6 1.1 0.77 10.7 0.0 3.5 4 1 1 5 5 5 0 Tetratricopeptide repeat ChAPs PF09295.10 ETO23761.1 - 0.03 13.3 0.1 0.049 12.6 0.1 1.2 1 0 0 1 1 1 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_1 PF00515.28 ETO23761.1 - 0.048 13.5 1.0 4.1 7.4 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 ETO23761.1 - 0.07 13.6 1.4 7.1 7.1 0.5 3.1 2 1 0 2 2 2 0 Bacterial transcriptional activator domain DUF4525 PF15027.6 ETO23761.1 - 0.16 11.7 1.2 0.5 10.1 0.6 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4525) RP-C_C PF11800.8 ETO23761.1 - 0.24 11.5 0.1 0.24 11.5 0.1 2.3 2 1 0 2 2 2 0 Replication protein C C-terminal region PUB PF09409.10 ETO23762.1 - 3.7e-07 30.0 0.2 8.1e-07 28.9 0.2 1.6 1 0 0 1 1 1 1 PUB domain Plasmodium_Vir PF05795.11 ETO23762.1 - 0.035 13.6 4.6 0.0097 15.4 2.0 1.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein MMPL PF03176.15 ETO23763.1 - 6.7e-13 48.3 8.3 9.1e-13 47.8 8.3 1.1 1 0 0 1 1 1 1 MMPL family CopD PF05425.13 ETO23763.1 - 0.73 10.2 5.1 1 9.8 4.2 1.7 1 1 1 2 2 2 0 Copper resistance protein D DUF2157 PF09925.9 ETO23763.1 - 4.2 7.1 6.4 10 5.9 6.4 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) DUF679 PF05078.12 ETO23764.1 - 0.0085 16.1 0.6 0.016 15.1 0.4 1.6 1 1 1 2 2 2 1 Protein of unknown function (DUF679) CAP_GLY PF01302.25 ETO23765.1 - 4.8e-14 52.1 0.3 1.7e-13 50.4 0.3 1.8 2 0 0 2 2 2 1 CAP-Gly domain RPEL PF02755.15 ETO23765.1 - 0.0022 17.6 2.4 0.0052 16.4 0.4 2.4 2 0 0 2 2 2 1 RPEL repeat RasGEF PF00617.19 ETO23766.1 - 1.8e-43 148.8 0.3 1.8e-43 148.8 0.3 1.7 2 0 0 2 2 2 1 RasGEF domain PEHE PF15275.6 ETO23766.1 - 0.014 16.0 1.8 0.042 14.5 1.8 1.8 1 0 0 1 1 1 0 PEHE domain DUF2807 PF10988.8 ETO23767.1 - 0.0096 15.7 2.9 0.021 14.6 2.9 1.6 1 0 0 1 1 1 1 Putative auto-transporter adhesin, head GIN domain SR-25 PF10500.9 ETO23767.1 - 0.068 12.8 15.7 0.11 12.1 15.7 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAD_binding_3 PF01494.19 ETO23769.1 - 0.12 11.5 0.1 0.19 11.0 0.1 1.2 1 0 0 1 1 1 0 FAD binding domain Glutaredoxin PF00462.24 ETO23770.1 - 5.9e-07 29.6 0.0 1.4e-06 28.4 0.0 1.7 1 0 0 1 1 1 1 Glutaredoxin G-patch_2 PF12656.7 ETO23770.1 - 0.047 13.8 0.0 0.77 9.9 0.0 2.7 3 0 0 3 3 3 0 G-patch domain Shisa PF13908.6 ETO23771.1 - 0.17 12.1 0.0 0.3 11.3 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Nop14 PF04147.12 ETO23773.1 - 4.2 5.5 37.6 5.4 5.1 37.6 1.1 1 0 0 1 1 1 0 Nop14-like family NS3_envE PF02723.14 ETO23775.1 - 0.039 14.0 1.9 0.1 12.7 1.9 1.7 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E Y2_Tnp PF04986.13 ETO23777.1 - 0.01 15.9 0.5 0.016 15.3 0.5 1.3 1 0 0 1 1 1 0 Putative transposase DUF4160 PF13711.6 ETO23777.1 - 0.13 12.6 1.9 0.33 11.3 1.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4160) Pneumo_att_G PF05539.11 ETO23779.1 - 1.3 8.5 11.6 1.6 8.2 11.6 1.0 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G Dicty_REP PF05086.12 ETO23779.1 - 3.1 5.7 7.8 3.3 5.6 7.8 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RR_TM4-6 PF06459.12 ETO23779.1 - 4.7 7.0 10.5 6.6 6.5 10.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 UCH PF00443.29 ETO23780.1 - 8e-26 91.1 2.9 1.1e-25 90.6 2.9 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Armet PF10208.9 ETO23780.1 - 0.057 13.3 0.1 0.12 12.3 0.1 1.5 1 0 0 1 1 1 0 Degradation arginine-rich protein for mis-folding SAP PF02037.27 ETO23780.1 - 0.077 12.8 0.6 0.077 12.8 0.6 1.9 2 0 0 2 2 2 0 SAP domain Fer4_17 PF13534.6 ETO23781.1 - 0.0038 17.7 2.5 0.12 12.9 0.1 2.2 2 0 0 2 2 2 1 4Fe-4S dicluster domain DUF1201 PF06716.11 ETO23781.1 - 0.01 15.8 5.0 0.019 15.0 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1201) Fer4_10 PF13237.6 ETO23781.1 - 0.03 14.4 1.7 5.6 7.2 0.1 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain DUF1712 PF08217.11 ETO23781.1 - 0.14 10.6 0.0 0.2 10.1 0.0 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1712) Fer4_8 PF13183.6 ETO23781.1 - 0.45 11.0 4.0 5.5 7.5 0.2 2.2 2 0 0 2 2 2 0 4Fe-4S dicluster domain MutS_V PF00488.21 ETO23782.1 - 1.5e-37 129.5 0.1 3.4e-20 72.9 0.0 3.3 3 1 0 3 3 3 3 MutS domain V Phage_ABA_S PF18066.1 ETO23782.1 - 0.14 12.8 0.0 4.7 8.0 0.0 2.4 1 1 1 2 2 2 0 Phage ABA sandwich domain MutS_III PF05192.18 ETO23783.1 - 2.1e-21 77.0 0.1 4.3e-21 76.0 0.0 1.5 2 0 0 2 2 2 1 MutS domain III DUF5081 PF16887.5 ETO23783.1 - 0.031 13.4 1.5 0.051 12.6 1.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5081) Tubulin PF00091.25 ETO23785.1 - 2.4e-59 200.9 0.0 4.2e-59 200.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO23785.1 - 3.6e-35 120.9 0.1 6.1e-35 120.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.25 ETO23785.1 - 0.022 14.6 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) UPF0203 PF05254.12 ETO23785.1 - 0.035 14.3 1.5 0.27 11.5 0.1 2.6 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0203) Tubulin_2 PF13809.6 ETO23785.1 - 0.19 10.9 0.0 0.32 10.1 0.0 1.3 1 0 0 1 1 1 0 Tubulin like DUF913 PF06025.12 ETO23786.1 - 0.017 14.1 0.1 0.019 13.9 0.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RGS PF00615.19 ETO23787.1 - 0.00017 21.9 0.5 0.0002 21.6 0.5 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain DAGK_cat PF00781.24 ETO23789.1 - 0.00047 19.8 0.0 0.00056 19.5 0.0 1.2 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain DUF4270 PF14092.6 ETO23789.1 - 0.045 12.9 0.1 0.054 12.6 0.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4270) Arginase PF00491.21 ETO23789.1 - 0.053 13.0 0.0 0.062 12.8 0.0 1.0 1 0 0 1 1 1 0 Arginase family DUF3269 PF11673.8 ETO23790.1 - 0.0029 17.9 0.2 0.0047 17.3 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3269) RNA_pol_Rpb1_7 PF04990.12 ETO23790.1 - 0.15 12.1 4.1 2.7 8.0 4.1 2.1 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 7 Vps52 PF04129.12 ETO23793.1 - 0.0082 14.9 3.9 0.013 14.3 3.9 1.3 1 0 0 1 1 1 1 Vps52 / Sac2 family FlaC_arch PF05377.11 ETO23793.1 - 0.46 10.9 5.7 0.15 12.5 1.8 2.1 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DrrA_P4M PF14860.6 ETO23793.1 - 2.8 7.9 8.1 0.33 10.8 1.3 2.3 2 0 0 2 2 2 0 DrrA phosphatidylinositol 4-phosphate binding domain zf-CCCH PF00642.24 ETO23794.1 - 2.6e-09 36.7 14.2 0.0002 21.2 1.0 2.2 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO23794.1 - 1.8e-07 30.9 23.8 0.0011 19.0 10.7 2.3 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 ETO23794.1 - 0.0001 23.0 8.9 0.004 17.8 0.3 2.3 1 1 1 2 2 2 2 Torus domain zf-CCCH_4 PF18044.1 ETO23794.1 - 0.00014 21.6 16.5 0.043 13.6 1.4 2.3 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_3 PF15663.5 ETO23794.1 - 0.13 12.5 3.7 3.7 7.8 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger containing family Apt1 PF10351.9 ETO23795.1 - 0.0015 17.4 3.7 0.0022 16.9 3.7 1.2 1 0 0 1 1 1 1 Golgi-body localisation protein domain Presenilin PF01080.17 ETO23795.1 - 0.002 17.0 0.7 0.0027 16.6 0.0 1.6 2 0 0 2 2 2 1 Presenilin Zip PF02535.22 ETO23795.1 - 0.78 8.9 5.3 0.62 9.2 3.4 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Orf78 PF06024.12 ETO23795.1 - 2.9 8.2 6.7 64 3.9 3.6 3.3 2 1 0 2 2 2 0 Orf78 (ac78) Pkinase PF00069.25 ETO23796.1 - 2.6e-58 197.5 0.0 7.8e-52 176.2 0.0 3.0 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23796.1 - 1.7e-27 96.3 0.0 8.7e-27 94.0 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO23796.1 - 2.9e-05 24.1 0.1 0.0041 17.1 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ETO23796.1 - 9.4e-05 21.9 0.0 0.00016 21.1 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO23796.1 - 0.004 16.5 0.0 0.0071 15.7 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kelch_1 PF01344.25 ETO23797.1 - 1.7e-07 30.7 2.1 7.4e-05 22.2 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO23797.1 - 0.00029 21.0 3.7 0.021 15.1 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO23797.1 - 0.0014 18.6 2.9 0.0027 17.7 0.0 2.9 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO23797.1 - 0.0037 17.2 4.5 23 5.1 0.0 5.2 4 1 0 4 4 4 0 Kelch motif PTEN_C2 PF10409.9 ETO23797.1 - 0.022 14.5 0.3 0.096 12.4 0.3 2.1 1 1 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein tRNA_Me_trans PF03054.16 ETO23797.1 - 0.046 12.5 2.2 0.093 11.5 0.4 1.9 2 0 0 2 2 2 0 tRNA methyl transferase Kelch_3 PF13415.6 ETO23797.1 - 0.12 12.7 0.0 0.7 10.2 0.0 2.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO23797.1 - 0.39 10.8 7.8 6.1 7.0 0.2 4.5 4 1 1 5 5 5 0 Kelch motif WD40 PF00400.32 ETO23798.1 - 7.5e-55 181.7 24.9 5.2e-09 36.6 0.2 7.9 7 1 1 8 8 8 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO23798.1 - 3.1e-17 62.5 0.8 0.1 11.5 0.0 6.0 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO23798.1 - 8.5e-17 61.2 0.3 0.0018 18.5 0.0 5.8 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO23798.1 - 3.9e-08 33.4 0.1 0.0083 16.0 0.0 2.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO23798.1 - 2.5e-06 26.3 0.3 0.086 11.4 0.1 3.0 3 0 0 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO23798.1 - 2.6e-06 26.4 4.5 0.5 9.0 0.0 4.9 1 1 2 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO23798.1 - 3.7e-06 26.5 0.7 0.013 14.9 0.0 2.7 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO23798.1 - 2e-05 24.4 8.0 4.7 7.3 0.0 5.5 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO23798.1 - 0.0047 16.0 0.2 0.5 9.4 0.1 3.0 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain MCM6_C PF18263.1 ETO23799.1 - 0.066 13.5 5.5 0.3 11.3 0.7 3.2 1 1 1 2 2 2 0 MCM6 C-terminal winged-helix domain MutS_V PF00488.21 ETO23801.1 - 2.1e-58 197.5 0.0 2.7e-58 197.1 0.0 1.1 1 0 0 1 1 1 1 MutS domain V DUF3439 PF11921.8 ETO23803.1 - 8.4e-05 22.5 8.8 0.00038 20.4 1.3 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF3439) TMEM237 PF15383.6 ETO23803.1 - 1.9 7.5 4.0 12 4.9 0.3 2.1 2 0 0 2 2 2 0 Transmembrane protein 237 DUF4752 PF15944.5 ETO23804.1 - 0.14 12.2 0.2 0.38 10.8 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4752) Presenilin PF01080.17 ETO23804.1 - 4 6.1 7.1 10 4.8 7.1 1.6 1 0 0 1 1 1 0 Presenilin Rcd1 PF04078.13 ETO23805.1 - 0.047 13.0 0.0 0.81 8.9 0.0 2.2 2 0 0 2 2 2 0 Cell differentiation family, Rcd1-like Hormone_recep PF00104.30 ETO23807.1 - 0.034 13.7 2.0 0.065 12.8 0.3 2.2 2 1 0 2 2 2 0 Ligand-binding domain of nuclear hormone receptor DUF2564 PF10819.8 ETO23808.1 - 0.022 15.1 0.1 0.022 15.1 0.1 2.6 4 0 0 4 4 4 0 Protein of unknown function (DUF2564) Dna2 PF08696.11 ETO23808.1 - 0.055 13.3 5.1 0.1 12.4 5.1 1.5 1 0 0 1 1 1 0 DNA replication factor Dna2 TarH PF02203.15 ETO23808.1 - 0.18 11.7 3.3 0.15 12.0 0.8 2.0 2 0 0 2 2 2 0 Tar ligand binding domain homologue DUF745 PF05335.13 ETO23808.1 - 0.71 9.6 4.3 1.2 8.8 4.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF745) adh_short PF00106.25 ETO23811.1 - 6e-13 48.7 1.0 1.2e-05 24.9 0.3 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO23811.1 - 3.8e-06 26.6 1.3 0.0042 16.7 0.0 2.2 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO23811.1 - 3.6e-05 23.7 0.5 0.00014 21.8 0.5 1.8 1 1 0 1 1 1 1 KR domain Sel1 PF08238.12 ETO23812.1 - 4.2e-13 49.5 8.8 6.2e-05 23.5 0.0 6.8 8 0 0 8 8 8 4 Sel1 repeat TPR_11 PF13414.6 ETO23812.1 - 0.055 13.2 0.9 0.36 10.5 0.1 2.7 2 0 0 2 2 2 0 TPR repeat TPR_10 PF13374.6 ETO23812.1 - 0.086 12.7 0.2 0.45 10.5 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat EamA PF00892.20 ETO23814.1 - 6.9e-06 26.3 27.5 0.0016 18.6 4.9 3.8 4 0 0 4 4 4 2 EamA-like transporter family YjcB PF15940.5 ETO23814.1 - 0.088 13.0 0.7 0.33 11.2 0.7 2.0 1 0 0 1 1 1 0 Family of unknown function AAA_15 PF13175.6 ETO23815.1 - 0.089 12.5 43.0 0.18 11.5 43.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain SSP160 PF06933.11 ETO23815.1 - 2 6.5 10.4 2.7 6.1 10.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 NIF PF03031.18 ETO23816.1 - 1.3e-17 64.0 0.0 1.5e-17 63.8 0.0 1.1 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Proteasome PF00227.26 ETO23818.1 - 5.6e-40 136.9 0.0 9.4e-40 136.1 0.0 1.3 1 0 0 1 1 1 1 Proteasome subunit Proteasome_A_N PF10584.9 ETO23818.1 - 3.7e-15 55.3 0.1 6.6e-15 54.5 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature gpW PF02831.15 ETO23818.1 - 0.023 14.6 0.1 0.072 13.0 0.0 1.8 2 0 0 2 2 2 0 gpW AAA_2 PF07724.14 ETO23819.1 - 5.1e-44 150.4 0.1 1.4e-43 148.9 0.1 1.8 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) Ank_2 PF12796.7 ETO23819.1 - 2.2e-12 47.4 0.0 1.4e-11 44.8 0.0 2.3 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) ClpB_D2-small PF10431.9 ETO23819.1 - 8.4e-12 45.0 1.0 1.8e-11 43.9 0.0 2.2 2 0 0 2 2 1 1 C-terminal, D2-small domain, of ClpB protein AAA_5 PF07728.14 ETO23819.1 - 8.9e-11 41.9 0.0 3.8e-10 39.9 0.0 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) Ank PF00023.30 ETO23819.1 - 7.8e-10 38.8 0.0 0.0031 17.9 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ETO23819.1 - 8.4e-10 39.0 0.0 0.0022 18.5 0.0 3.4 1 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO23819.1 - 5.1e-09 35.6 0.0 0.021 15.3 0.0 3.7 3 0 0 3 3 3 2 Ankyrin repeat Sigma54_activat PF00158.26 ETO23819.1 - 3.7e-07 30.0 0.0 7e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Sigma-54 interaction domain Ank_5 PF13857.6 ETO23819.1 - 7.3e-07 29.3 0.1 0.02 15.2 0.0 3.5 2 1 1 3 3 3 3 Ankyrin repeats (many copies) AAA PF00004.29 ETO23819.1 - 9.4e-07 29.3 0.0 2.6e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Torsin PF06309.11 ETO23819.1 - 6.8e-05 23.0 0.0 0.00029 20.9 0.0 2.0 2 0 0 2 2 2 1 Torsin Mg_chelatase PF01078.21 ETO23819.1 - 0.001 18.5 0.0 0.03 13.7 0.0 2.3 1 1 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_22 PF13401.6 ETO23819.1 - 0.0017 18.6 0.0 0.01 16.1 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ETO23819.1 - 0.0036 17.2 0.0 0.034 14.0 0.0 2.3 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Zeta_toxin PF06414.12 ETO23819.1 - 0.0081 15.5 0.0 0.018 14.3 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_7 PF12775.7 ETO23819.1 - 0.011 15.3 0.0 0.9 9.0 0.0 2.4 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_16 PF13191.6 ETO23819.1 - 0.016 15.6 0.6 0.12 12.8 0.0 2.6 2 1 1 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 ETO23819.1 - 0.026 14.7 1.0 0.61 10.2 0.0 2.9 3 0 0 3 3 2 0 AAA domain IstB_IS21 PF01695.17 ETO23819.1 - 0.058 13.1 0.0 1.8 8.2 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein RNA_helicase PF00910.22 ETO23819.1 - 0.065 13.6 0.1 0.53 10.7 0.0 2.4 2 0 0 2 2 2 0 RNA helicase NB-ARC PF00931.22 ETO23819.1 - 0.076 12.2 0.0 0.18 11.0 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain ABC_tran PF00005.27 ETO23819.1 - 0.084 13.4 0.1 0.33 11.5 0.0 2.1 2 0 0 2 2 1 0 ABC transporter RsgA_GTPase PF03193.16 ETO23819.1 - 0.084 12.8 0.0 0.2 11.6 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 ETO23819.1 - 0.11 13.1 0.2 0.77 10.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain SRP54 PF00448.22 ETO23819.1 - 0.11 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain NACHT PF05729.12 ETO23819.1 - 0.13 12.2 0.0 0.46 10.4 0.0 2.0 2 0 0 2 2 1 0 NACHT domain Glyco_transf_49 PF13896.6 ETO23820.1 - 0.007 15.8 0.4 1.4 8.2 0.1 2.3 2 0 0 2 2 2 2 Glycosyl-transferase for dystroglycan IF3_C PF00707.22 ETO23820.1 - 0.083 12.9 0.0 0.15 12.0 0.0 1.3 1 0 0 1 1 1 0 Translation initiation factor IF-3, C-terminal domain WD40 PF00400.32 ETO23821.1 - 9e-42 140.3 12.7 9.4e-09 35.8 0.0 8.3 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23821.1 - 2.2e-18 66.4 0.1 0.00012 22.3 0.0 6.2 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO23821.1 - 1.7e-09 37.6 6.7 0.00011 22.4 0.1 5.4 6 1 0 6 6 6 3 Kelch motif Ge1_WD40 PF16529.5 ETO23821.1 - 1e-06 28.0 0.3 2 7.3 0.1 5.5 4 1 1 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_1 PF01344.25 ETO23821.1 - 2.6e-06 26.9 1.0 0.064 12.9 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO23821.1 - 7.2e-06 25.8 5.0 0.011 15.7 0.1 5.4 6 0 0 6 6 5 1 Kelch motif Kelch_4 PF13418.6 ETO23821.1 - 3.4e-05 23.8 5.6 3.6e-05 23.7 0.1 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO23821.1 - 0.00037 20.7 0.1 0.11 12.8 0.0 4.2 4 0 0 4 4 4 1 Galactose oxidase, central domain PD40 PF07676.12 ETO23821.1 - 0.00053 19.9 2.5 4.8 7.2 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO23821.1 - 0.001 19.0 6.2 0.018 15.1 0.4 3.3 3 0 0 3 3 3 1 Kelch motif WD40_like PF17005.5 ETO23821.1 - 0.0028 17.0 12.2 0.01 15.2 0.0 3.1 4 0 0 4 4 3 2 WD40-like domain KIAA1430 PF13879.6 ETO23821.1 - 0.023 15.4 5.2 0.059 14.1 5.2 1.6 1 0 0 1 1 1 0 KIAA1430 homologue Cytochrom_D1 PF02239.16 ETO23821.1 - 0.032 12.8 0.1 2.2 6.7 0.0 2.9 3 0 0 3 3 3 0 Cytochrome D1 heme domain HIP1_clath_bdg PF16515.5 ETO23821.1 - 0.16 12.6 5.3 0.29 11.7 5.3 1.3 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Nup160 PF11715.8 ETO23821.1 - 0.17 10.5 7.3 7.1 5.1 0.6 4.0 2 1 0 3 3 3 0 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETO23821.1 - 2.3 8.0 8.6 39 4.0 0.0 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Kelch_1 PF01344.25 ETO23822.1 - 0.036 13.6 0.0 0.22 11.1 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO23822.1 - 0.039 13.9 0.4 0.32 11.0 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO23822.1 - 0.045 14.1 0.1 0.37 11.1 0.0 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO23822.1 - 0.12 12.4 1.3 3.5 7.7 0.0 3.7 5 1 0 5 5 5 0 Kelch motif NdhM PF10664.9 ETO23823.1 - 0.013 15.8 0.4 0.015 15.5 0.4 1.2 1 0 0 1 1 1 0 Cyanobacterial and plastid NDH-1 subunit M Nbs1_C PF08599.10 ETO23823.1 - 0.036 14.2 0.8 0.067 13.3 0.4 1.8 1 1 0 1 1 1 0 DNA damage repair protein Nbs1 DUF4446 PF14584.6 ETO23823.1 - 0.038 14.0 2.8 0.042 13.8 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Metallophos_C PF14008.6 ETO23823.1 - 0.057 14.3 0.8 3.5 8.6 0.8 2.3 1 1 0 1 1 1 0 Iron/zinc purple acid phosphatase-like protein C TBCA PF02970.16 ETO23823.1 - 0.22 11.9 9.9 0.27 11.6 9.9 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A zf-C4H2 PF10146.9 ETO23823.1 - 0.5 10.7 11.9 0.62 10.3 11.9 1.1 1 0 0 1 1 1 0 Zinc finger-containing protein VPS38 PF17649.1 ETO23823.1 - 0.87 8.4 11.3 0.98 8.2 11.3 1.0 1 0 0 1 1 1 0 Vacuolar protein sorting 38 Atg14 PF10186.9 ETO23823.1 - 5.7 5.9 10.7 7.1 5.6 10.7 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 WD40 PF00400.32 ETO23824.1 - 9e-48 159.3 13.4 1.4e-08 35.3 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23824.1 - 3.9e-20 71.9 3.2 0.00037 20.7 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23824.1 - 5.5e-14 51.9 1.1 0.031 13.2 0.0 6.5 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO23824.1 - 8.8e-11 42.0 0.4 0.00026 20.9 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO23824.1 - 1.3e-07 30.7 1.6 0.43 9.2 0.1 4.8 1 1 2 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO23824.1 - 3.2e-07 30.1 4.3 1.3 9.1 0.0 6.0 7 0 0 7 7 6 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO23824.1 - 1.8e-06 27.5 0.7 2.5 7.4 0.0 4.3 1 1 3 4 4 4 3 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO23824.1 - 2.2e-06 27.5 0.1 3.7e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 PQQ-like domain Nucleoporin_N PF08801.11 ETO23824.1 - 1e-05 24.5 8.1 0.001 17.9 2.3 3.4 1 1 1 3 3 3 2 Nup133 N terminal like Str_synth PF03088.16 ETO23824.1 - 2.4e-05 24.4 0.4 0.64 10.2 0.0 4.7 3 2 3 6 6 6 1 Strictosidine synthase WD40_like PF17005.5 ETO23824.1 - 3.1e-05 23.4 2.0 0.23 10.7 0.0 3.2 1 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO23824.1 - 0.00026 19.7 0.4 0.68 8.4 0.0 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO23824.1 - 0.0042 16.0 0.2 0.2 10.5 0.0 2.9 3 1 1 4 4 4 1 Methylamine dehydrogenase heavy chain (MADH) TFIIIC_delta PF12657.7 ETO23824.1 - 0.032 14.1 0.5 8.4 6.3 0.1 3.5 2 2 0 2 2 2 0 Transcription factor IIIC subunit delta N-term PQQ PF01011.21 ETO23824.1 - 0.033 14.1 0.6 86 3.3 0.0 4.5 5 0 0 5 5 5 0 PQQ enzyme repeat HARP PF07443.13 ETO23824.1 - 0.056 13.1 0.0 10 5.9 0.0 3.4 3 0 0 3 3 3 0 HepA-related protein (HARP) DHFR_2 PF06442.11 ETO23824.1 - 0.15 11.9 0.0 2.5 8.0 0.0 2.6 3 1 0 3 3 3 0 R67 dihydrofolate reductase Utp8 PF10395.9 ETO23824.1 - 0.19 10.2 0.8 32 2.8 0.1 3.4 2 1 1 3 3 3 0 Utp8 family Proteasome_A_N PF10584.9 ETO23824.1 - 0.26 11.0 11.8 7.9 6.3 0.0 5.3 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature 7tm_1 PF00001.21 ETO23825.1 - 0.021 14.2 1.8 0.68 9.2 0.1 2.3 2 0 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) AI-2E_transport PF01594.16 ETO23825.1 - 0.027 13.6 0.1 0.065 12.4 0.1 1.6 1 0 0 1 1 1 0 AI-2E family transporter DUF2304 PF10066.9 ETO23825.1 - 0.29 11.4 4.1 10 6.4 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) DUF1440 PF07274.12 ETO23825.1 - 0.52 10.7 3.0 16 5.8 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1440) Orf78 PF06024.12 ETO23825.1 - 0.69 10.2 3.9 0.21 11.9 0.2 2.1 2 1 0 2 2 2 0 Orf78 (ac78) ETRAMP PF09716.10 ETO23825.1 - 5.5 7.1 10.0 9 6.4 0.4 3.4 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) BTB PF00651.31 ETO23826.1 - 7.8e-21 74.4 0.5 1.1e-18 67.4 0.2 2.4 2 0 0 2 2 2 2 BTB/POZ domain BRCT_2 PF16589.5 ETO23827.1 - 1.5e-13 51.0 0.2 7.8e-09 35.8 0.0 2.4 2 1 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETO23827.1 - 6.3e-11 42.5 0.2 3.4e-05 24.2 0.0 2.4 2 0 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_5 PF16770.5 ETO23827.1 - 4e-07 29.8 0.1 6.9e-06 25.9 0.0 2.4 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 ETO23827.1 - 2.7e-05 24.2 0.1 0.068 13.3 0.0 2.4 2 1 0 2 2 2 2 BRCA1 C Terminus (BRCT) domain Response_reg PF00072.24 ETO23827.1 - 0.15 12.2 0.0 0.27 11.4 0.0 1.3 1 0 0 1 1 1 0 Response regulator receiver domain DUF5053 PF16476.5 ETO23829.1 - 0.089 12.5 0.3 2.9 7.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5053) zf-RING_UBOX PF13445.6 ETO23831.1 - 4e-05 23.5 10.1 4e-05 23.5 10.1 2.2 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO23831.1 - 0.0035 17.2 8.0 0.0035 17.2 8.0 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO23831.1 - 0.0077 16.1 5.4 0.0077 16.1 5.4 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO23831.1 - 0.0089 15.9 12.4 0.0089 15.9 12.4 2.5 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) FSA_C PF10479.9 ETO23831.1 - 0.031 12.4 3.8 0.14 10.3 0.4 2.1 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus zf-RING_5 PF14634.6 ETO23831.1 - 0.031 14.3 15.1 0.4 10.7 15.3 2.7 1 1 2 3 3 3 0 zinc-RING finger domain zf-RING_2 PF13639.6 ETO23831.1 - 0.081 13.3 17.4 0.47 10.8 16.2 2.5 1 1 1 2 2 2 0 Ring finger domain Prok-RING_4 PF14447.6 ETO23831.1 - 0.37 10.7 16.0 9 6.2 10.4 3.2 2 1 1 3 3 3 0 Prokaryotic RING finger family 4 DUF3439 PF11921.8 ETO23831.1 - 0.59 10.1 23.4 2.6 8.0 8.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO23831.1 - 0.78 7.6 20.9 1.2 7.1 2.3 2.2 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein Rtf2 PF04641.12 ETO23831.1 - 2.3 7.5 13.0 12 5.2 13.0 2.1 1 1 0 1 1 1 0 Rtf2 RING-finger zf-C3HC4_4 PF15227.6 ETO23831.1 - 8.4 6.6 17.7 0.074 13.2 9.0 2.1 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_6 PF14835.6 ETO23831.1 - 8.6 6.3 10.6 5.1 7.0 6.5 2.4 2 1 0 2 2 2 0 zf-RING of BARD1-type protein AJAP1_PANP_C PF15298.6 ETO23831.1 - 9.9 6.3 16.5 6 7.0 2.7 2.2 2 0 0 2 2 2 0 AJAP1/PANP C-terminus DUF5129 PF17173.4 ETO23832.1 - 0.026 13.7 3.1 0.042 13.0 3.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5129) Borrelia_P83 PF05262.11 ETO23832.1 - 0.087 11.3 8.0 0.08 11.4 6.7 1.5 2 0 0 2 2 2 0 Borrelia P83/100 protein Spem1 PF15670.5 ETO23832.1 - 0.22 11.1 10.9 0.66 9.5 6.4 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 VSG_B PF13206.6 ETO23832.1 - 0.66 9.2 7.1 0.95 8.7 7.1 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain AUX_IAA PF02309.16 ETO23832.1 - 0.7 9.7 8.5 0.39 10.5 0.3 2.2 2 0 0 2 2 2 0 AUX/IAA family DUF501 PF04417.12 ETO23832.1 - 0.94 9.3 6.7 1.9 8.3 6.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF501) AAA_23 PF13476.6 ETO23832.1 - 2.9 8.3 14.3 5.5 7.4 14.3 1.5 1 0 0 1 1 1 0 AAA domain DUF4606 PF15379.6 ETO23832.1 - 3.3 8.0 15.2 0.079 13.2 6.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4606) EMC3_TMCO1 PF01956.16 ETO23832.1 - 4.7 6.9 17.0 0.2 11.3 10.1 2.1 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like CAP_GLY PF01302.25 ETO23833.1 - 1.3e-39 134.1 10.6 4.2e-20 71.5 0.4 3.7 4 0 0 4 4 4 3 CAP-Gly domain DnaJ_CXXCXGXG PF00684.19 ETO23833.1 - 0.0017 18.7 4.4 0.0047 17.3 3.5 2.1 1 1 1 2 2 2 2 DnaJ central domain YajC PF02699.15 ETO23833.1 - 0.0096 15.8 0.9 0.18 11.7 0.1 2.4 1 1 1 2 2 2 1 Preprotein translocase subunit zinc_ribbon_10 PF10058.9 ETO23833.1 - 0.035 13.9 1.8 0.076 12.8 0.3 2.2 2 0 0 2 2 2 0 Predicted integral membrane zinc-ribbon metal-binding protein Anti-TRAP PF15777.5 ETO23833.1 - 0.093 12.7 1.7 5.6 7.0 0.3 2.9 3 0 0 3 3 3 0 Tryptophan RNA-binding attenuator protein inhibitory protein DUF1272 PF06906.11 ETO23833.1 - 0.64 10.1 0.1 0.64 10.1 0.1 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF1272) EMC3_TMCO1 PF01956.16 ETO23834.1 - 4.2e-30 104.7 0.2 4.2e-30 104.7 0.2 1.9 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like DrsE_2 PF13686.6 ETO23834.1 - 0.15 11.9 0.0 0.27 11.1 0.0 1.4 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family EF-hand_7 PF13499.6 ETO23835.1 - 3.2e-08 33.9 5.2 0.0011 19.4 0.3 2.4 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO23835.1 - 1.5e-07 30.4 7.6 0.00032 20.0 0.4 4.2 4 0 0 4 4 4 2 EF hand EF-hand_6 PF13405.6 ETO23835.1 - 8.1e-07 28.5 10.7 0.00017 21.2 0.3 3.5 3 1 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ETO23835.1 - 6e-05 22.8 4.3 0.073 12.9 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO23835.1 - 0.00014 21.2 9.1 0.004 16.6 0.2 3.4 4 0 0 4 4 4 2 EF hand Caleosin PF05042.13 ETO23835.1 - 0.0005 20.0 0.9 0.46 10.4 0.2 2.2 2 0 0 2 2 2 2 Caleosin related protein SPARC_Ca_bdg PF10591.9 ETO23835.1 - 0.013 15.8 2.9 1.8 8.9 0.3 2.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF1187 PF06688.11 ETO23835.1 - 0.15 12.4 0.5 0.93 9.9 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1187) EF-hand_6 PF13405.6 ETO23836.1 - 0.0044 16.8 1.3 0.86 9.7 0.3 2.7 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO23836.1 - 0.014 15.9 2.1 0.098 13.1 2.1 2.2 1 1 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 ETO23836.1 - 0.031 14.1 0.8 0.18 11.7 0.4 2.3 2 0 0 2 2 2 0 EF-hand domain pair FRB_dom PF08771.11 ETO23836.1 - 0.047 14.1 0.1 0.079 13.4 0.1 1.4 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain Lar_N PF09861.9 ETO23836.1 - 0.16 11.2 0.0 0.18 10.9 0.0 1.2 1 0 0 1 1 1 0 Lactate racemase N-terminal domain Tom37 PF10568.9 ETO23837.1 - 1.6 9.0 8.7 12 6.3 0.0 3.9 4 0 0 4 4 4 0 Outer mitochondrial membrane transport complex protein Arg_decarbox_C PF17944.1 ETO23837.1 - 6.1 7.5 9.8 7.7 7.2 0.4 4.5 4 1 1 5 5 5 0 Arginine decarboxylase C-terminal helical extension 5-FTHF_cyc-lig PF01812.20 ETO23838.1 - 4.4e-34 118.0 0.0 1.2e-32 113.3 0.0 2.0 1 1 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family SWIB PF02201.18 ETO23839.1 - 0.11 12.3 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 SWIB/MDM2 domain Choline_transpo PF04515.12 ETO23840.1 - 1.6e-53 182.1 14.8 1.6e-53 182.1 14.8 2.3 2 0 0 2 2 2 1 Plasma-membrane choline transporter Ribosomal_60s PF00428.19 ETO23841.1 - 4 8.1 15.0 1.5 9.5 7.1 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein Dicty_REP PF05086.12 ETO23842.1 - 0.074 11.0 1.5 0.089 10.8 1.5 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO23842.1 - 0.14 12.1 4.5 0.28 11.1 4.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO23842.1 - 0.39 8.9 5.9 0.62 8.2 5.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 SP_C-Propep PF08999.10 ETO23843.1 - 0.064 13.0 3.7 0.13 12.0 3.7 1.5 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide Wzy_C PF04932.15 ETO23843.1 - 0.077 12.6 0.3 0.22 11.2 0.3 1.8 1 0 0 1 1 1 0 O-Antigen ligase HemY_N PF07219.13 ETO23843.1 - 0.61 10.3 2.3 0.56 10.4 0.5 1.8 2 0 0 2 2 2 0 HemY protein N-terminus Pkinase PF00069.25 ETO23844.1 - 2.4e-07 30.4 0.3 3.3e-07 29.9 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23844.1 - 0.0078 15.5 0.1 0.011 15.1 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UPF0184 PF03670.13 ETO23846.1 - 1.1 9.7 6.5 0.19 12.1 0.5 2.8 4 0 0 4 4 4 0 Uncharacterised protein family (UPF0184) DEAD PF00270.29 ETO23847.1 - 1.5e-08 34.6 0.0 1.9e-08 34.3 0.0 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO23847.1 - 7e-06 26.4 0.0 1.2e-05 25.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETO23847.1 - 0.00019 21.8 0.0 0.0003 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 ETO23847.1 - 0.0039 17.2 0.0 0.0057 16.6 0.0 1.3 1 0 0 1 1 1 1 Flavivirus DEAD domain ResIII PF04851.15 ETO23847.1 - 0.023 14.7 0.7 1.2 9.1 0.7 2.1 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETO23847.1 - 0.046 13.4 0.0 0.057 13.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ETO23847.1 - 0.056 12.7 0.0 0.078 12.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) LAP1C PF05609.12 ETO23848.1 - 0.002 17.3 20.6 0.011 14.8 3.4 2.2 2 0 0 2 2 2 2 Lamina-associated polypeptide 1C (LAP1C) TFIIA PF03153.13 ETO23848.1 - 0.36 10.8 25.7 0.68 9.9 19.1 2.2 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Hamartin PF04388.12 ETO23848.1 - 2.2 6.8 24.4 3.1 6.3 24.4 1.2 1 0 0 1 1 1 0 Hamartin protein DUF1264 PF06884.11 ETO23849.1 - 0.022 14.4 0.0 0.043 13.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1264) HBS1_N PF08938.10 ETO23849.1 - 0.028 14.7 1.8 0.073 13.4 0.3 2.4 2 0 0 2 2 2 0 HBS1 N-terminus Podoplanin PF05808.11 ETO23851.1 - 0.0011 19.1 5.2 0.0011 19.1 5.2 3.1 2 1 0 2 2 2 1 Podoplanin DUF5383 PF17355.2 ETO23851.1 - 0.0017 18.8 1.9 0.0017 18.8 1.9 2.8 3 1 0 3 3 3 1 Family of unknown function (DUF5383) RIFIN PF02009.16 ETO23851.1 - 0.0047 16.9 11.6 0.0047 16.9 11.6 2.8 1 1 1 3 3 3 1 Rifin Peptidase_M13_N PF05649.13 ETO23852.1 - 0.097 12.3 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Peptidase family M13 OCD_Mu_crystall PF02423.15 ETO23853.1 - 6.1e-06 25.4 0.0 1.5e-05 24.1 0.0 1.6 1 1 0 1 1 1 1 Ornithine cyclodeaminase/mu-crystallin family DOCK_N PF16172.5 ETO23854.1 - 0.13 11.1 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 DOCK N-terminus GIT_CC PF16559.5 ETO23855.1 - 0.14 12.0 1.0 7.8 6.4 0.1 2.2 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor RRM_1 PF00076.22 ETO23856.1 - 4.2e-16 58.5 0.1 4.3e-09 36.1 0.0 2.2 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO23856.1 - 0.011 15.6 0.0 0.071 13.0 0.0 2.1 2 0 0 2 2 2 0 Occluded RNA-recognition motif Limkain-b1 PF11608.8 ETO23856.1 - 0.014 15.4 0.0 0.52 10.4 0.0 2.3 2 0 0 2 2 2 0 Limkain b1 EF-hand_6 PF13405.6 ETO23857.1 - 1.5e-05 24.5 0.0 0.055 13.4 0.0 2.8 2 1 1 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ETO23857.1 - 4.3e-05 23.3 0.2 0.79 9.6 0.0 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO23857.1 - 0.0037 16.7 0.0 1.8 8.3 0.0 2.7 2 1 1 3 3 3 2 EF hand EF-hand_7 PF13499.6 ETO23857.1 - 0.0071 16.8 0.0 0.014 15.9 0.0 1.6 1 1 0 1 1 1 1 EF-hand domain pair I-EGF_1 PF18372.1 ETO23857.1 - 0.033 14.3 1.0 0.051 13.7 1.0 1.3 1 0 0 1 1 1 0 Integrin beta epidermal growth factor like domain 1 mTERF PF02536.14 ETO23857.1 - 0.072 12.0 0.1 0.072 12.0 0.1 1.1 1 0 0 1 1 1 0 mTERF WD40 PF00400.32 ETO23858.1 - 5.6e-57 188.4 12.9 3.5e-10 40.3 0.1 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23858.1 - 2.8e-20 72.4 2.1 0.0016 18.7 0.1 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23858.1 - 9.7e-12 44.5 1.0 0.073 12.0 0.0 5.6 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO23858.1 - 9.9e-09 34.9 1.0 0.00022 20.7 0.0 2.8 1 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO23858.1 - 1.2e-08 34.1 2.5 0.058 12.0 0.0 4.1 2 1 2 4 4 4 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO23858.1 - 1e-05 25.5 2.0 6 6.9 0.1 4.6 3 1 1 5 5 5 2 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 ETO23858.1 - 0.0075 14.8 0.5 6.1 5.3 0.0 2.9 1 1 2 3 3 3 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO23858.1 - 0.025 14.5 0.0 29 4.8 0.0 4.3 3 1 1 4 4 4 0 PQQ enzyme repeat Frtz PF11768.8 ETO23858.1 - 0.027 12.8 0.1 0.082 11.2 0.1 1.7 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Vac_Fusion PF02346.16 ETO23858.1 - 0.038 13.6 0.2 0.78 9.4 0.1 2.9 2 1 1 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 Ricin_B_lectin PF00652.22 ETO23858.1 - 0.068 13.4 0.8 9.6 6.5 0.1 2.5 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain VID27 PF08553.10 ETO23858.1 - 0.076 12.0 0.1 1.4 7.9 0.0 2.3 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO23858.1 - 0.1 12.6 0.7 13 5.9 0.0 4.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat MMR_HSR1 PF01926.23 ETO23859.1 - 3e-08 33.8 0.3 4.3e-08 33.2 0.3 1.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase AIG1 PF04548.16 ETO23859.1 - 6.8e-05 22.3 0.4 8.5e-05 22.0 0.4 1.1 1 0 0 1 1 1 1 AIG1 family RsgA_GTPase PF03193.16 ETO23859.1 - 0.00046 20.1 0.7 0.0041 17.0 0.2 2.1 2 0 0 2 2 2 1 RsgA GTPase ABC_tran PF00005.27 ETO23859.1 - 0.012 16.1 0.8 0.016 15.7 0.8 1.3 1 1 0 1 1 1 0 ABC transporter DUF87 PF01935.17 ETO23859.1 - 0.015 15.4 1.5 0.27 11.3 0.3 2.0 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_22 PF13401.6 ETO23859.1 - 0.099 12.9 0.0 0.12 12.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain MOR2-PAG1_C PF14225.6 ETO23860.1 - 1e-10 41.9 0.6 4.1e-10 40.0 0.1 2.0 2 0 0 2 2 2 1 Cell morphogenesis C-terminal TRAP_alpha PF03896.16 ETO23861.1 - 2.9e-06 26.7 0.9 3.3e-06 26.5 0.9 1.1 1 0 0 1 1 1 1 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 ETO23861.1 - 0.013 15.2 7.3 0.023 14.3 7.3 1.5 1 1 0 1 1 1 0 FAM176 family ETRAMP PF09716.10 ETO23861.1 - 0.022 14.8 3.0 0.052 13.6 3.0 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF4834 PF16118.5 ETO23861.1 - 0.022 15.7 0.0 0.032 15.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) TRAM_LAG1_CLN8 PF03798.16 ETO23861.1 - 0.12 12.1 3.6 1.2 8.8 0.4 2.0 2 0 0 2 2 2 0 TLC domain Atrophin-1 PF03154.15 ETO23861.1 - 0.44 8.8 1.3 0.51 8.6 1.3 1.0 1 0 0 1 1 1 0 Atrophin-1 family MOEP19 PF16005.5 ETO23864.1 - 0.0015 18.5 0.5 0.0092 16.0 0.1 2.1 2 0 0 2 2 2 1 KH-like RNA-binding domain Secretin_N_2 PF07655.13 ETO23864.1 - 0.015 15.8 7.0 0.015 15.8 7.0 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain ArsA_HSP20 PF17886.1 ETO23864.1 - 0.015 14.8 0.0 0.031 13.8 0.0 1.5 1 0 0 1 1 1 0 HSP20-like domain found in ArsA WD40 PF00400.32 ETO23864.1 - 0.017 16.0 7.5 0.06 14.2 0.3 4.3 5 0 0 5 5 5 0 WD domain, G-beta repeat Thioredoxin_3 PF13192.6 ETO23864.1 - 0.018 15.0 0.1 0.044 13.8 0.1 1.6 1 0 0 1 1 1 0 Thioredoxin domain ETRAMP PF09716.10 ETO23864.1 - 0.21 11.7 7.8 2.8 8.1 0.2 2.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ZZ PF00569.17 ETO23865.1 - 1.1e-08 34.8 22.2 1.6e-05 24.6 2.3 4.8 5 0 0 5 5 5 2 Zinc finger, ZZ type zf-Di19 PF05605.12 ETO23865.1 - 0.00011 22.4 2.6 0.00011 22.4 2.6 3.0 3 0 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding AP3D1 PF06375.11 ETO23865.1 - 0.01 16.0 8.0 0.01 16.0 8.0 4.0 3 1 0 3 3 3 0 AP-3 complex subunit delta-1 BCS1_N PF08740.11 ETO23865.1 - 0.054 13.5 1.0 0.45 10.5 0.0 2.5 2 0 0 2 2 2 0 BCS1 N terminal BUD22 PF09073.10 ETO23865.1 - 0.52 9.6 22.5 0.31 10.3 4.8 2.2 2 0 0 2 2 2 0 BUD22 Rtf2 PF04641.12 ETO23865.1 - 8.8 5.6 16.6 0.87 8.9 4.5 2.4 2 0 0 2 2 2 0 Rtf2 RING-finger MMPL PF03176.15 ETO23866.1 - 5e-26 91.4 10.8 1.3e-24 86.8 13.2 2.0 2 1 0 2 2 2 1 MMPL family V_ATPase_I PF01496.19 ETO23867.1 - 0.00047 18.2 0.0 0.00059 17.9 0.0 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family FAM176 PF14851.6 ETO23867.1 - 0.0025 17.5 0.2 0.0039 16.9 0.2 1.4 1 0 0 1 1 1 1 FAM176 family TRP PF06011.12 ETO23867.1 - 0.02 13.7 3.3 0.032 13.0 3.3 1.3 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel CRA PF06589.11 ETO23867.1 - 0.034 14.2 1.7 0.034 14.2 1.7 1.8 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) RXT2_N PF08595.11 ETO23867.1 - 0.048 13.7 7.2 0.074 13.1 7.2 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal S-antigen PF05756.11 ETO23867.1 - 0.15 12.4 10.3 0.43 11.0 10.3 1.8 1 0 0 1 1 1 0 S-antigen protein Pox_Ag35 PF03286.14 ETO23867.1 - 0.32 10.8 12.4 0.46 10.2 12.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ETO23867.1 - 0.42 9.8 2.3 1.4 8.1 0.5 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF2457 PF10446.9 ETO23867.1 - 0.47 9.5 12.5 0.58 9.2 12.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PBP1_TM PF14812.6 ETO23867.1 - 0.67 10.4 8.9 2 8.8 8.9 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TLD PF07534.16 ETO23868.1 - 3e-13 50.2 0.0 6.2e-13 49.1 0.0 1.5 1 0 0 1 1 1 1 TLD DASH_Dad2 PF08654.10 ETO23868.1 - 0.0061 17.0 2.8 0.015 15.7 2.5 1.7 1 1 0 1 1 1 1 DASH complex subunit Dad2 GAS PF13851.6 ETO23868.1 - 0.2 11.0 13.1 0.32 10.3 13.1 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding CLZ PF16526.5 ETO23868.1 - 0.45 10.9 13.1 2.9 8.3 0.5 3.7 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Fib_alpha PF08702.10 ETO23868.1 - 0.58 10.3 11.0 1.9 8.7 11.0 1.9 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Jnk-SapK_ap_N PF09744.9 ETO23868.1 - 0.63 10.3 13.4 2 8.6 12.8 1.9 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Tn7_Tnp_TnsA_C PF08721.11 ETO23868.1 - 0.82 10.3 3.8 0.57 10.9 0.6 2.3 2 0 0 2 2 2 0 TnsA endonuclease C terminal ORF6C PF10552.9 ETO23868.1 - 1.5 8.9 11.9 2.7 8.1 3.8 3.0 2 1 1 3 3 3 0 ORF6C domain DUF1664 PF07889.12 ETO23868.1 - 1.8 8.6 12.0 3.6 7.6 4.8 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DASH_Dad3 PF08656.10 ETO23868.1 - 2.5 8.2 7.3 0.34 11.0 1.1 2.5 2 1 0 2 2 2 0 DASH complex subunit Dad3 XhlA PF10779.9 ETO23868.1 - 5.4 7.3 11.2 0.16 12.2 2.5 2.4 2 1 0 2 2 2 0 Haemolysin XhlA Corona_nucleoca PF00937.18 ETO23869.1 - 0.019 14.0 1.3 0.038 13.0 1.3 1.4 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Telomere_reg-2 PF10193.9 ETO23869.1 - 0.044 14.2 0.3 0.13 12.7 0.3 1.8 1 1 0 1 1 1 0 Telomere length regulation protein WWE PF02825.20 ETO23870.1 - 4.1e-07 30.5 0.0 1.8e-06 28.4 0.0 2.2 1 0 0 1 1 1 1 WWE domain Endonuclea_NS_2 PF13930.6 ETO23870.1 - 0.0049 17.0 1.4 0.047 13.8 1.1 2.5 2 0 0 2 2 2 1 DNA/RNA non-specific endonuclease CPSF100_C PF13299.6 ETO23870.1 - 2.4 8.3 9.9 6.8 6.8 1.4 3.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal Peptidase_S49_N PF08496.10 ETO23870.1 - 3.8 7.6 8.7 0.26 11.3 1.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Peptidase_C65 PF10275.9 ETO23871.1 - 8.4e-22 77.8 0.1 1.2e-21 77.2 0.1 1.2 1 0 0 1 1 1 1 Peptidase C65 Otubain OTU PF02338.19 ETO23871.1 - 0.066 13.7 0.2 0.17 12.4 0.0 1.8 2 0 0 2 2 2 0 OTU-like cysteine protease Presenilin PF01080.17 ETO23872.1 - 5.2e-13 48.5 21.3 5.2e-13 48.5 21.3 3.0 3 0 0 3 3 3 3 Presenilin YL1 PF05764.13 ETO23873.1 - 0.68 10.0 31.3 1.2 9.2 31.3 1.3 1 0 0 1 1 1 0 YL1 nuclear protein LAP1C PF05609.12 ETO23873.1 - 0.72 8.9 21.2 1 8.4 21.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Apt1 PF10351.9 ETO23873.1 - 0.77 8.5 17.5 1.1 8.0 17.5 1.3 1 0 0 1 1 1 0 Golgi-body localisation protein domain DUF4692 PF15763.5 ETO23873.1 - 2.3 8.7 11.3 0.57 10.6 7.6 1.7 1 1 1 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) TipE PF16972.5 ETO23873.1 - 2.4 7.3 8.1 3.3 6.8 8.1 1.2 1 0 0 1 1 1 0 Na+ channel auxiliary subunit TipE RNA_pol_3_Rpc31 PF11705.8 ETO23873.1 - 4.8 7.4 23.2 0.097 12.9 9.5 2.5 2 1 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 PI3K_1B_p101 PF10486.9 ETO23873.1 - 6.7 4.4 15.5 8.8 4.0 15.5 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pkinase PF00069.25 ETO23874.1 - 1.6e-39 135.9 0.4 1.6e-39 135.9 0.4 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23874.1 - 5.1e-30 104.6 0.3 1e-29 103.6 0.3 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO23874.1 - 8.6e-08 31.4 0.5 1.9e-07 30.3 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO23874.1 - 0.007 15.4 0.0 0.007 15.4 0.0 1.5 2 0 0 2 2 2 1 Haspin like kinase domain DUF1589 PF07628.11 ETO23874.1 - 0.0089 16.2 0.0 0.015 15.4 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1589) Kdo PF06293.14 ETO23874.1 - 0.016 14.6 0.2 0.032 13.6 0.0 1.5 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO23874.1 - 0.025 13.9 0.0 0.055 12.8 0.0 1.5 1 0 0 1 1 1 0 Kinase-like YqgF PF14639.6 ETO23874.1 - 0.035 13.9 0.0 0.093 12.5 0.0 1.7 1 0 0 1 1 1 0 Holliday-junction resolvase-like of SPT6 APH PF01636.23 ETO23874.1 - 0.047 13.6 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family RIO1 PF01163.22 ETO23874.1 - 0.13 11.9 0.0 0.13 11.9 0.0 1.7 2 0 0 2 2 2 0 RIO1 family OmpH PF03938.14 ETO23875.1 - 3.5 7.9 17.8 4.6 7.6 5.0 2.4 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) DUF4041 PF13250.6 ETO23876.1 - 0.023 14.6 0.1 0.049 13.5 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4041) SirA PF10747.9 ETO23876.1 - 0.041 14.2 0.2 0.041 14.2 0.2 2.0 2 0 0 2 2 2 0 Sporulation inhibitor of replication protein SirA DUF3391 PF11871.8 ETO23876.1 - 0.049 14.2 2.1 0.088 13.3 2.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3391) Peptidase_S46 PF10459.9 ETO23876.1 - 0.69 8.5 6.6 0.73 8.4 6.6 1.0 1 0 0 1 1 1 0 Peptidase S46 YqzH PF14164.6 ETO23876.1 - 9.1 6.4 8.5 4.3 7.5 1.8 2.8 2 2 0 2 2 2 0 YqzH-like protein ubiquitin PF00240.23 ETO23877.1 - 4.6e-10 39.1 0.0 7.6e-10 38.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO23877.1 - 5.9e-09 35.6 0.1 1e-08 34.9 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like zinc_ribbon_4 PF13717.6 ETO23877.1 - 0.039 13.9 0.9 0.088 12.8 0.1 2.0 2 0 0 2 2 2 0 zinc-ribbon domain CTV_P23 PF04808.12 ETO23879.1 - 0.15 11.6 2.3 0.39 10.2 2.1 1.8 2 0 0 2 2 2 0 Citrus tristeza virus (CTV) P23 protein NPAT_C PF15712.5 ETO23879.1 - 3.3 6.2 6.8 4.3 5.9 6.8 1.1 1 0 0 1 1 1 0 NPAT C terminus RNA_pol PF00940.19 ETO23880.1 - 8.9e-83 278.4 0.4 3.8e-82 276.3 0.4 1.7 1 1 0 1 1 1 1 DNA-dependent RNA polymerase CRA_rpt PF07046.11 ETO23880.1 - 0.12 12.6 0.1 0.18 12.0 0.1 1.3 1 0 0 1 1 1 0 Cytoplasmic repetitive antigen (CRA) like repeat Macoilin PF09726.9 ETO23882.1 - 0.076 11.6 28.5 0.093 11.3 28.5 1.1 1 0 0 1 1 1 0 Macoilin family Mucin PF01456.17 ETO23882.1 - 0.13 12.3 10.1 0.24 11.4 10.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Nup54 PF13874.6 ETO23882.1 - 1.1 9.3 8.1 1.9 8.6 6.1 2.1 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Serinc PF03348.15 ETO23882.1 - 7.6 5.3 5.9 11 4.9 5.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) Aldo_ket_red PF00248.21 ETO23883.1 - 3e-23 82.5 0.0 6.2e-23 81.4 0.0 1.4 2 0 0 2 2 2 1 Aldo/keto reductase family Methyltransf_31 PF13847.6 ETO23884.1 - 4.8e-10 39.4 0.0 8.9e-10 38.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO23884.1 - 1e-07 32.6 0.0 3e-07 31.0 0.0 1.9 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETO23884.1 - 1.8e-07 30.9 0.0 3.8e-07 29.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain PrmC_N PF17827.1 ETO23884.1 - 4.1e-05 24.1 0.7 0.00011 22.7 0.4 2.0 2 1 0 2 2 2 1 PrmC N-terminal domain Methyltransf_12 PF08242.12 ETO23884.1 - 6.5e-05 23.6 0.0 0.00023 21.8 0.0 2.0 1 1 1 2 2 2 1 Methyltransferase domain PrmA PF06325.13 ETO23884.1 - 0.00063 19.2 0.0 0.0014 18.1 0.0 1.5 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_16 PF10294.9 ETO23884.1 - 0.0027 17.5 0.0 0.0062 16.3 0.0 1.5 1 0 0 1 1 1 1 Lysine methyltransferase Methyltransf_11 PF08241.12 ETO23884.1 - 0.0031 18.1 0.0 0.0071 17.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ETO23884.1 - 0.0047 16.6 0.0 0.0088 15.7 0.0 1.4 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 N6_Mtase PF02384.16 ETO23884.1 - 0.025 13.9 0.0 0.04 13.2 0.0 1.3 1 0 0 1 1 1 0 N-6 DNA Methylase Methyltransf_4 PF02390.17 ETO23884.1 - 0.034 13.6 0.0 0.073 12.5 0.0 1.6 1 0 0 1 1 1 0 Putative methyltransferase Eco57I PF07669.11 ETO23884.1 - 0.044 14.3 0.0 0.34 11.4 0.0 2.3 2 0 0 2 2 2 0 Eco57I restriction-modification methylase Cons_hypoth95 PF03602.15 ETO23884.1 - 0.044 13.4 0.0 0.11 12.1 0.0 1.6 2 0 0 2 2 2 0 Conserved hypothetical protein 95 AdoMet_MTase PF07757.13 ETO23884.1 - 0.082 13.3 0.0 0.17 12.2 0.0 1.5 1 0 0 1 1 1 0 Predicted AdoMet-dependent methyltransferase PCMT PF01135.19 ETO23884.1 - 0.086 12.6 0.0 0.14 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) zf-RING_2 PF13639.6 ETO23885.1 - 8.7e-08 32.4 14.3 8.7e-08 32.4 14.3 3.6 2 1 0 2 2 2 1 Ring finger domain zf-C3HC4 PF00097.25 ETO23885.1 - 4.9e-05 23.1 15.1 4.9e-05 23.1 15.1 3.4 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO23885.1 - 6.1e-05 22.7 11.8 6.1e-05 22.7 11.8 3.5 3 0 0 3 3 3 1 RING-like zinc finger zf-rbx1 PF12678.7 ETO23885.1 - 0.00062 20.0 10.5 0.00062 20.0 10.5 3.7 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETO23885.1 - 0.00075 19.3 13.2 0.00075 19.3 13.2 3.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO23885.1 - 0.013 15.4 14.4 0.013 15.4 14.4 3.4 2 1 0 2 2 2 0 zinc-RING finger domain zf-ANAPC11 PF12861.7 ETO23885.1 - 0.018 15.1 4.1 0.018 15.1 4.1 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Pap_E4 PF02711.14 ETO23885.1 - 0.77 10.8 2.8 1.1 10.2 0.5 2.6 2 0 0 2 2 2 0 E4 protein Ctr PF04145.15 ETO23885.1 - 8.6 7.0 5.7 2.8 8.6 0.9 2.7 2 2 0 2 2 2 0 Ctr copper transporter family DUF2615 PF11027.8 ETO23886.1 - 0.099 12.8 1.0 0.4 10.8 1.0 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2615) MIEAP PF16026.5 ETO23887.1 - 1e-05 25.9 0.0 1e-05 25.9 0.0 3.3 1 1 3 4 4 4 2 Mitochondria-eating protein RNA_polI_A14 PF08203.11 ETO23887.1 - 0.59 10.9 0.1 0.59 10.9 0.1 3.1 4 0 0 4 4 4 0 Yeast RNA polymerase I subunit RPA14 Rtt102p PF09510.10 ETO23887.1 - 6.9 6.9 10.7 2 8.6 6.5 2.2 1 1 0 2 2 2 0 Rtt102p-like transcription regulator protein Pkinase PF00069.25 ETO23888.1 - 1.3e-14 54.2 0.0 2.1e-14 53.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO23888.1 - 1.5e-09 37.2 0.0 2.3e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Pkinase_Tyr PF07714.17 ETO23888.1 - 0.00032 20.1 0.1 0.00076 18.8 0.0 1.7 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO23888.1 - 0.006 16.0 0.0 0.013 14.9 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO23888.1 - 0.0078 16.2 0.0 0.019 14.9 0.0 1.6 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ETO23888.1 - 0.026 13.5 0.0 0.044 12.8 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Filament PF00038.21 ETO23889.1 - 0.00085 19.0 4.2 0.0013 18.4 4.2 1.2 1 0 0 1 1 1 1 Intermediate filament protein DUF3450 PF11932.8 ETO23889.1 - 0.015 14.6 5.1 0.023 14.0 5.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Exonuc_VII_L PF02601.15 ETO23889.1 - 0.5 9.9 5.6 0.86 9.1 5.6 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pterin_bind PF00809.22 ETO23890.1 - 5.4e-48 163.8 0.0 2.7e-47 161.5 0.0 2.0 1 1 0 1 1 1 1 Pterin binding enzyme TPR_2 PF07719.17 ETO23891.1 - 0.00011 22.0 0.1 0.03 14.4 0.0 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO23891.1 - 0.0035 16.8 0.0 0.0066 15.9 0.0 1.5 1 0 0 1 1 1 1 SHNi-TPR TPR_8 PF13181.6 ETO23891.1 - 0.039 14.2 0.2 4 7.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4518 PF15008.6 ETO23891.1 - 0.078 12.1 4.6 0.031 13.5 1.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4518) WBP-1 PF11669.8 ETO23891.1 - 0.46 11.2 11.7 0.5 11.0 2.8 3.0 2 1 1 3 3 3 0 WW domain-binding protein 1 WD40 PF00400.32 ETO23892.1 - 2e-27 94.9 20.6 2.1e-06 28.3 0.2 7.0 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23892.1 - 5.5e-10 39.4 0.8 0.014 15.6 0.1 4.6 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Antig_Caf1 PF09255.10 ETO23892.1 - 0.0013 18.9 0.4 0.0041 17.2 0.2 1.9 2 0 0 2 2 2 1 Caf1 Capsule antigen DUF4893 PF16233.5 ETO23892.1 - 0.036 13.7 0.3 0.1 12.2 0.1 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4893) GAS PF13851.6 ETO23893.1 - 0.0035 16.7 22.1 0.0035 16.7 22.1 3.7 3 0 0 3 3 3 2 Growth-arrest specific micro-tubule binding COG2 PF06148.11 ETO23893.1 - 2.1 8.4 20.7 0.045 13.9 7.7 3.2 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Surfac_D-trimer PF09006.11 ETO23893.1 - 2.2 8.2 4.7 4.5 7.2 0.7 2.8 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation DUF1664 PF07889.12 ETO23893.1 - 3.3 7.8 19.1 3.2 7.8 6.1 3.5 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) HisKA PF00512.25 ETO23893.1 - 6.2 6.9 9.3 26 4.9 2.3 3.2 2 1 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF2956 PF11169.8 ETO23894.1 - 0.01 16.0 5.0 0.01 16.0 5.0 2.5 2 1 0 2 2 2 1 Protein of unknown function (DUF2956) Apis_Csd PF11671.8 ETO23894.1 - 2.4 8.2 26.4 3.1 7.8 15.9 2.2 2 0 0 2 2 2 0 Complementary sex determiner protein FAM176 PF14851.6 ETO23894.1 - 7.2 6.3 14.8 5 6.8 0.9 2.2 2 0 0 2 2 2 0 FAM176 family ANAPC_CDC26 PF10471.9 ETO23894.1 - 7.7 7.4 23.4 2.1 9.2 11.7 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex APC subunit CDC26 Dynamitin PF04912.14 ETO23895.1 - 8.2e-24 84.6 5.3 9e-24 84.5 5.3 1.0 1 0 0 1 1 1 1 Dynamitin DUF3080 PF11279.8 ETO23895.1 - 0.021 14.0 6.1 0.058 12.6 0.6 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF3080) Lectin_N PF03954.14 ETO23895.1 - 0.033 13.9 0.5 0.033 13.9 0.5 1.9 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain Allexi_40kDa PF05549.11 ETO23895.1 - 0.29 10.6 4.2 0.21 11.0 0.4 2.1 2 0 0 2 2 2 0 Allexivirus 40kDa protein RRM_1 PF00076.22 ETO23896.1 - 5.6e-07 29.3 0.5 0.00038 20.2 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2431 PF10354.9 ETO23897.1 - 1.9e-27 96.6 1.9 2.5e-27 96.2 0.0 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF2431) zf-C2H2_4 PF13894.6 ETO23897.1 - 4.7e-05 23.9 33.1 0.12 13.3 3.5 5.3 5 0 0 5 5 5 3 C2H2-type zinc finger zf-C2H2_3rep PF18868.1 ETO23897.1 - 0.00074 20.2 12.1 0.00074 20.2 12.1 2.9 2 1 0 2 2 2 1 Zinc finger C2H2-type, 3 repeats zinc_ribbon_15 PF17032.5 ETO23897.1 - 0.0089 16.8 8.7 1.7 9.4 3.8 2.8 2 0 0 2 2 2 2 zinc-ribbon family zf_Hakai PF18408.1 ETO23897.1 - 0.13 12.0 5.7 1.4 8.6 3.2 3.0 2 0 0 2 2 2 0 C2H2 Hakai zinc finger domain zf-C2H2_jaz PF12171.8 ETO23897.1 - 0.23 11.8 28.0 0.078 13.3 2.9 4.4 4 0 0 4 4 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 ETO23897.1 - 0.25 11.9 27.8 1.7 9.2 0.2 5.3 4 0 0 4 4 4 0 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ETO23897.1 - 0.26 11.7 25.5 0.96 9.8 7.8 3.5 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) PyrI_C PF02748.15 ETO23897.1 - 0.3 11.0 6.3 0.83 9.6 0.8 3.4 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain OTT_1508_deam PF14441.6 ETO23897.1 - 0.76 9.8 12.6 0.25 11.4 0.3 3.7 3 1 0 3 3 3 0 OTT_1508-like deaminase ADK_lid PF05191.14 ETO23897.1 - 1.8 8.6 8.9 0.82 9.7 0.2 3.1 3 0 0 3 3 3 0 Adenylate kinase, active site lid zf-met2 PF12907.7 ETO23897.1 - 2.5 8.3 14.2 2.5 8.3 0.2 3.7 3 0 0 3 3 3 0 Zinc-binding zf-met PF12874.7 ETO23897.1 - 6.4 7.3 24.5 1.4 9.5 0.1 4.4 4 0 0 4 4 4 0 Zinc-finger of C2H2 type Ribonuc_L-PSP PF01042.21 ETO23900.1 - 7.7e-39 132.5 0.1 9.6e-39 132.1 0.1 1.1 1 0 0 1 1 1 1 Endoribonuclease L-PSP Ras PF00071.22 ETO23901.1 - 1.2e-40 138.7 1.5 1.4e-21 76.8 0.1 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO23901.1 - 9.5e-19 67.8 1.5 6.6e-17 61.8 1.5 2.4 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO23901.1 - 0.019 14.9 1.8 0.12 12.3 0.1 2.8 2 2 2 4 4 4 0 RsgA GTPase AAA_16 PF13191.6 ETO23901.1 - 0.029 14.8 0.0 0.19 12.1 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETO23901.1 - 0.035 14.4 0.1 0.16 12.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain Hpr_kinase_C PF07475.12 ETO23901.1 - 0.039 13.5 0.1 4 7.0 0.0 2.3 2 0 0 2 2 2 0 HPr Serine kinase C-terminal domain AAA_29 PF13555.6 ETO23901.1 - 0.09 12.5 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF563 PF04577.14 ETO23902.1 - 1.2e-15 58.2 0.0 2.9e-12 47.2 0.0 3.1 3 1 0 3 3 3 2 Protein of unknown function (DUF563) zf-TRAF PF02176.18 ETO23903.1 - 0.0002 22.0 1.1 0.0002 22.0 1.1 2.8 1 1 1 2 2 2 1 TRAF-type zinc finger OmpH PF03938.14 ETO23903.1 - 0.0043 17.4 1.3 0.0043 17.4 1.3 2.4 2 1 0 2 2 1 1 Outer membrane protein (OmpH-like) RasGAP_C PF03836.15 ETO23903.1 - 0.005 17.0 2.5 0.005 17.0 2.5 2.4 2 1 0 3 3 3 1 RasGAP C-terminus ADIP PF11559.8 ETO23903.1 - 0.019 15.1 3.5 0.019 15.1 3.5 3.0 3 0 0 3 3 3 0 Afadin- and alpha -actinin-Binding HR1 PF02185.16 ETO23903.1 - 0.1 12.7 8.1 0.34 11.1 7.0 2.3 1 1 1 2 2 2 0 Hr1 repeat TcdB_N PF12918.7 ETO23903.1 - 0.42 10.9 5.3 0.25 11.7 2.0 2.4 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain DUF641 PF04859.12 ETO23903.1 - 0.74 10.2 8.5 0.19 12.0 3.1 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) DUF4094 PF13334.6 ETO23903.1 - 0.85 10.1 5.6 0.59 10.6 2.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) zf-C3HC4_2 PF13923.6 ETO23903.1 - 2.2 8.2 7.2 0.9 9.4 1.5 3.2 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) TMF_DNA_bd PF12329.8 ETO23903.1 - 2.4 8.2 10.5 0.14 12.2 2.0 2.9 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding FlaC_arch PF05377.11 ETO23903.1 - 2.7 8.5 5.4 3.5 8.1 0.7 2.8 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) MMR_HSR1 PF01926.23 ETO23905.1 - 4.5e-06 26.7 0.0 4.5e-06 26.7 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_18 PF13238.6 ETO23905.1 - 0.00023 21.7 0.0 0.00023 21.7 0.0 2.4 2 1 0 2 2 1 1 AAA domain G-alpha PF00503.20 ETO23905.1 - 0.00044 19.5 0.1 0.00044 19.5 0.1 2.2 2 0 0 2 2 2 1 G-protein alpha subunit RsgA_GTPase PF03193.16 ETO23905.1 - 0.00067 19.6 5.2 0.025 14.5 3.4 3.0 1 1 1 2 2 2 1 RsgA GTPase SRP54 PF00448.22 ETO23905.1 - 0.0033 17.1 0.3 0.065 12.9 0.3 2.4 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain AIG1 PF04548.16 ETO23905.1 - 0.012 15.0 0.6 0.012 15.0 0.6 2.9 2 1 0 2 2 1 0 AIG1 family Gtr1_RagA PF04670.12 ETO23905.1 - 0.018 14.4 0.2 0.018 14.4 0.2 2.4 2 2 0 2 2 1 0 Gtr1/RagA G protein conserved region SapB_1 PF05184.15 ETO23905.1 - 0.022 14.8 0.5 0.051 13.6 0.5 1.6 1 0 0 1 1 1 0 Saposin-like type B, region 1 AAA_24 PF13479.6 ETO23905.1 - 0.024 14.4 0.1 0.024 14.4 0.1 2.5 2 1 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO23905.1 - 0.035 14.4 2.8 0.068 13.5 0.2 2.3 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO23905.1 - 0.053 13.3 0.1 0.13 12.0 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO23905.1 - 0.15 12.5 0.2 0.28 11.6 0.2 1.7 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ETO23905.1 - 0.15 12.2 1.0 0.32 11.2 0.0 2.0 2 1 0 2 2 2 0 AAA domain AAA_8 PF12780.7 ETO23905.1 - 0.17 11.2 0.0 0.17 11.2 0.0 2.5 3 0 0 3 3 3 0 P-loop containing dynein motor region D4 RLL PF10036.9 ETO23905.1 - 0.28 11.0 9.3 0.13 12.0 6.6 1.7 2 0 0 2 2 2 0 RNA transcription, translation and transport factor protein ABC_tran PF00005.27 ETO23905.1 - 0.41 11.2 5.1 0.28 11.7 0.2 2.3 1 1 1 2 2 2 0 ABC transporter Pox_Ag35 PF03286.14 ETO23905.1 - 1.5 8.6 21.7 9 6.0 20.4 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Radial_spoke_3 PF06098.11 ETO23905.1 - 2.7 7.2 11.6 4.2 6.6 11.6 1.4 1 0 0 1 1 1 0 Radial spoke protein 3 Mre11_DNA_bind PF04152.14 ETO23905.1 - 3 8.2 12.2 6.8 7.0 12.2 1.5 1 0 0 1 1 1 0 Mre11 DNA-binding presumed domain OAD_gamma PF04277.13 ETO23905.1 - 9.3 6.9 9.9 28 5.4 9.9 1.9 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Presenilin PF01080.17 ETO23905.1 - 9.5 4.9 5.7 12 4.6 5.7 1.1 1 0 0 1 1 1 0 Presenilin Claudin_2 PF13903.6 ETO23906.1 - 0.019 14.7 1.5 0.019 14.7 1.5 1.6 1 1 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Pkinase PF00069.25 ETO23907.1 - 6.9e-26 91.2 0.1 8.8e-26 90.8 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23907.1 - 4.5e-08 32.7 0.1 5.8e-08 32.3 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO23907.1 - 0.038 13.3 0.1 0.084 12.2 0.0 1.4 1 1 0 2 2 2 0 Kinase-like Secretin_N_2 PF07655.13 ETO23907.1 - 0.92 10.1 12.1 1.4 9.5 12.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Menin PF05053.13 ETO23907.1 - 1.1 7.6 9.7 1.4 7.2 9.7 1.1 1 0 0 1 1 1 0 Menin Filament PF00038.21 ETO23908.1 - 0.0045 16.6 12.5 0.0083 15.7 3.0 2.7 2 0 0 2 2 2 1 Intermediate filament protein Seryl_tRNA_N PF02403.22 ETO23908.1 - 0.012 15.8 17.5 0.17 12.1 0.7 3.7 3 1 1 4 4 4 0 Seryl-tRNA synthetase N-terminal domain Dfp1_Him1_M PF08630.10 ETO23908.1 - 0.019 15.2 0.7 0.019 15.2 0.7 2.5 2 0 0 2 2 2 0 Dfp1/Him1, central region SOGA PF11365.8 ETO23908.1 - 0.088 14.0 7.2 6.7 7.9 0.2 3.8 3 1 0 4 4 3 0 Protein SOGA DUF4094 PF13334.6 ETO23908.1 - 0.13 12.7 0.1 0.13 12.7 0.1 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) PspA_IM30 PF04012.12 ETO23908.1 - 0.24 10.9 16.6 0.17 11.4 6.4 2.5 2 0 0 2 2 2 0 PspA/IM30 family DUF4472 PF14739.6 ETO23908.1 - 0.26 12.0 20.2 0.082 13.6 2.8 3.3 3 0 0 3 3 2 0 Domain of unknown function (DUF4472) Lzipper-MIP1 PF14389.6 ETO23908.1 - 0.31 11.4 18.4 1 9.7 9.7 4.1 3 1 1 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 GTP-bdg_M PF16360.5 ETO23908.1 - 0.35 11.5 6.0 18 6.0 0.0 3.6 3 0 0 3 3 3 0 GTP-binding GTPase Middle Region APG6_N PF17675.1 ETO23908.1 - 0.5 10.9 25.5 0.14 12.7 3.7 3.3 3 1 0 3 3 3 0 Apg6 coiled-coil region FHIPEP PF00771.20 ETO23908.1 - 0.52 8.7 11.0 0.32 9.4 3.9 2.3 2 0 0 2 2 2 0 FHIPEP family ADIP PF11559.8 ETO23908.1 - 0.8 9.8 17.8 0.97 9.5 5.3 3.0 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF4140 PF13600.6 ETO23908.1 - 1 9.9 11.8 2.3 8.7 0.8 3.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Matrilin_ccoil PF10393.9 ETO23908.1 - 1.5 8.8 5.2 0.55 10.1 0.3 2.8 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Cep57_MT_bd PF06657.13 ETO23908.1 - 2.4 8.7 17.2 8.5 6.9 0.6 4.1 3 1 1 4 4 4 0 Centrosome microtubule-binding domain of Cep57 Translin PF01997.16 ETO23908.1 - 3 7.8 11.7 3.7 7.5 2.7 2.9 2 0 0 2 2 2 0 Translin family DUF4407 PF14362.6 ETO23908.1 - 3.1 7.1 10.5 12 5.1 0.6 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 ETO23908.1 - 3.4 7.9 11.8 5.8 7.2 0.6 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF5082) OmpH PF03938.14 ETO23908.1 - 4.7 7.5 16.1 0.29 11.5 1.8 3.1 3 0 0 3 3 2 0 Outer membrane protein (OmpH-like) DUF4200 PF13863.6 ETO23908.1 - 4.9 7.6 30.9 1.1 9.7 4.1 4.3 4 1 1 5 5 3 0 Domain of unknown function (DUF4200) CENP-F_leu_zip PF10473.9 ETO23908.1 - 6.8 6.7 24.4 1.6 8.8 6.7 3.6 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Prefoldin PF02996.17 ETO23908.1 - 7.2 6.5 13.6 16 5.4 0.5 4.2 4 1 1 5 5 4 0 Prefoldin subunit YabA PF06156.13 ETO23908.1 - 7.6 7.2 16.4 3.5 8.3 0.2 4.2 3 1 0 3 3 3 0 Initiation control protein YabA Adeno_E4 PF05385.11 ETO23910.1 - 0.12 12.4 0.0 2.9 8.1 0.0 2.5 2 0 0 2 2 2 0 Mastadenovirus early E4 13 kDa protein Ammonium_transp PF00909.21 ETO23911.1 - 4e-35 121.3 3.9 5.3e-35 120.9 3.9 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family DUF3021 PF11457.8 ETO23911.1 - 0.44 10.9 7.9 2.7 8.3 0.4 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3021) Ribosomal_S8e PF01201.22 ETO23912.1 - 1.2e-33 116.2 3.2 1.8e-33 115.6 3.2 1.3 1 0 0 1 1 1 1 Ribosomal protein S8e Oxidored_q3 PF00499.20 ETO23913.1 - 0.019 14.7 0.1 0.039 13.7 0.1 1.5 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 GRP PF07172.11 ETO23913.1 - 0.046 14.4 0.6 0.046 14.4 0.6 2.3 2 1 0 2 2 2 0 Glycine rich protein family OAD_gamma PF04277.13 ETO23913.1 - 0.83 10.3 10.8 0.36 11.4 0.4 3.3 2 1 1 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Pkinase PF00069.25 ETO23914.1 - 1.1e-52 179.0 0.0 1.3e-52 178.8 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23914.1 - 3.1e-33 115.2 0.0 3.6e-33 114.9 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO23914.1 - 5e-06 26.6 0.0 1.6e-05 25.0 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO23914.1 - 2.8e-05 23.6 0.0 3.7e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO23914.1 - 6.3e-05 21.9 0.0 6.3e-05 21.9 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO23914.1 - 0.00039 19.5 0.1 0.00048 19.2 0.1 1.1 1 0 0 1 1 1 1 Haspin like kinase domain Choline_kinase PF01633.20 ETO23914.1 - 0.0073 15.9 0.0 0.013 15.1 0.0 1.4 1 1 0 1 1 1 1 Choline/ethanolamine kinase RIO1 PF01163.22 ETO23914.1 - 0.0076 15.9 0.0 0.0096 15.5 0.0 1.1 1 0 0 1 1 1 1 RIO1 family Kinase-like PF14531.6 ETO23914.1 - 0.024 14.0 0.0 0.047 13.0 0.0 1.4 2 0 0 2 2 2 0 Kinase-like RabGAP-TBC PF00566.18 ETO23916.1 - 2.3e-06 27.4 0.1 4.4e-06 26.5 0.0 1.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain NDUF_B5 PF09781.9 ETO23916.1 - 0.018 14.6 0.9 0.032 13.8 0.9 1.4 1 0 0 1 1 1 0 NADH:ubiquinone oxidoreductase, NDUFB5/SGDH subunit WD40 PF00400.32 ETO23919.1 - 2.5e-68 224.3 16.3 1.1e-09 38.7 0.0 8.4 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23919.1 - 9.5e-18 64.3 0.4 0.017 15.4 0.0 6.9 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23919.1 - 5.5e-14 51.9 0.6 0.018 14.0 0.0 6.5 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO23919.1 - 5.8e-12 45.9 0.1 5.8e-06 26.3 0.1 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO23919.1 - 2e-10 40.5 5.3 8.2e-05 22.1 0.0 5.2 4 1 3 7 7 7 3 WD40-like domain Kelch_6 PF13964.6 ETO23919.1 - 1.4e-07 31.6 2.5 0.016 15.4 0.0 4.7 2 1 1 3 3 3 2 Kelch motif Cytochrom_D1 PF02239.16 ETO23919.1 - 2.7e-06 26.2 1.4 0.041 12.4 0.1 3.6 1 1 2 4 4 4 2 Cytochrome D1 heme domain Kelch_1 PF01344.25 ETO23919.1 - 5.8e-06 25.8 5.3 0.025 14.1 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Nup160 PF11715.8 ETO23919.1 - 1.2e-05 24.2 8.5 0.14 10.8 0.1 5.7 3 1 3 7 7 7 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO23919.1 - 4.5e-05 23.2 0.1 0.00041 20.0 0.2 2.4 2 0 0 2 2 2 1 PQQ-like domain Kelch_4 PF13418.6 ETO23919.1 - 0.00032 20.6 3.8 0.034 14.1 0.1 4.5 4 0 0 4 4 4 1 Galactose oxidase, central domain Nbas_N PF15492.6 ETO23919.1 - 0.00059 19.3 1.4 1 8.6 0.2 4.0 1 1 4 5 5 5 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO23919.1 - 0.002 18.0 5.2 4.1 7.5 0.1 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO23919.1 - 0.0039 17.1 7.2 4 7.5 0.2 4.8 5 0 0 5 5 5 2 Kelch motif Proteasome_A_N PF10584.9 ETO23919.1 - 0.016 14.9 1.7 37 4.1 0.0 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature HARP PF07443.13 ETO23919.1 - 0.019 14.6 0.1 1.5 8.6 0.0 3.2 3 0 0 3 3 3 0 HepA-related protein (HARP) SGL PF08450.12 ETO23919.1 - 0.021 14.4 0.2 0.1 12.2 0.1 2.1 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region PQQ PF01011.21 ETO23919.1 - 0.025 14.5 0.8 19 5.4 0.0 4.9 7 0 0 7 7 7 0 PQQ enzyme repeat Kelch_3 PF13415.6 ETO23919.1 - 0.044 14.1 0.4 0.97 9.8 0.0 3.3 4 0 0 4 4 4 0 Galactose oxidase, central domain Nucleoporin_N PF08801.11 ETO23919.1 - 0.061 12.0 5.8 0.57 8.9 0.6 3.7 1 1 3 4 4 4 0 Nup133 N terminal like DUF1797 PF08796.10 ETO23919.1 - 0.11 12.7 0.1 2.2 8.4 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) Fer4_14 PF13394.6 ETO23920.1 - 0.019 15.1 1.8 0.019 15.1 1.8 2.6 3 1 0 3 3 3 0 4Fe-4S single cluster domain CENP-B_dimeris PF09026.10 ETO23920.1 - 0.39 11.1 21.6 0.31 11.5 0.8 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain S-antigen PF05756.11 ETO23920.1 - 2.3 8.6 15.8 0.63 10.4 0.7 2.7 2 0 0 2 2 2 0 S-antigen protein DUF3852 PF12963.7 ETO23920.1 - 2.4 8.5 5.2 4.1 7.8 1.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3852) TIMP PF00965.17 ETO23923.1 - 0.0042 16.9 0.1 0.0053 16.6 0.1 1.1 1 0 0 1 1 1 1 Tissue inhibitor of metalloproteinase MBOAT_2 PF13813.6 ETO23923.1 - 0.041 14.2 0.0 0.066 13.5 0.0 1.3 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family DUF1981 PF09324.10 ETO23925.1 - 2.6e-33 113.7 1.0 8.9e-31 105.6 0.2 2.7 2 0 0 2 2 2 2 Domain of unknown function (DUF1981) Sec7 PF01369.20 ETO23926.1 - 1e-62 211.1 0.1 2e-62 210.1 0.1 1.5 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ETO23926.1 - 3.7e-07 30.2 0.2 1.8e-06 27.9 0.0 2.2 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DUF3439 PF11921.8 ETO23926.1 - 0.42 10.6 9.8 0.97 9.4 9.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Med3 PF11593.8 ETO23926.1 - 2.6 7.1 10.6 4.5 6.4 10.6 1.3 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Band_7 PF01145.25 ETO23928.1 - 9.4e-11 42.0 0.0 7.8e-09 35.8 0.0 2.5 2 0 0 2 2 2 2 SPFH domain / Band 7 family Pkinase PF00069.25 ETO23930.1 - 6.9e-37 127.2 0.0 9.9e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23930.1 - 2.2e-14 53.4 0.0 3.1e-14 52.9 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO23930.1 - 0.0016 18.4 0.0 0.0026 17.7 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO23930.1 - 0.042 13.2 0.0 0.071 12.4 0.0 1.3 1 0 0 1 1 1 0 Kinase-like Choline_kinase PF01633.20 ETO23930.1 - 0.043 13.4 0.0 0.088 12.4 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase XPG_N PF00752.17 ETO23931.1 - 3.6e-21 75.5 0.0 8.8e-21 74.3 0.0 1.6 2 0 0 2 2 2 1 XPG N-terminal domain TPR_8 PF13181.6 ETO23931.1 - 0.0082 16.3 0.1 0.025 14.8 0.1 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat MIT PF04212.18 ETO23931.1 - 0.0086 16.1 0.2 0.025 14.6 0.1 1.9 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_2 PF07719.17 ETO23931.1 - 0.017 15.2 0.0 0.04 14.0 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO23931.1 - 0.026 14.3 0.0 0.067 13.1 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat zf-C3HC4_3 PF13920.6 ETO23932.1 - 7.2e-12 45.0 15.9 4.1e-10 39.4 8.4 2.7 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO23932.1 - 6.5e-11 41.9 10.9 6.5e-11 41.9 10.9 2.7 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO23932.1 - 1.8e-09 37.4 5.9 1.8e-09 37.4 5.9 3.4 2 1 1 3 3 3 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO23932.1 - 4.1e-09 36.2 11.3 4.1e-09 36.2 11.3 2.8 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO23932.1 - 2.1e-08 34.4 10.3 2.1e-08 34.4 10.3 2.7 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETO23932.1 - 8.8e-07 28.8 18.8 2.1e-06 27.6 10.8 2.8 2 0 0 2 2 2 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO23932.1 - 9.6e-07 28.6 21.1 0.00039 20.2 13.0 3.6 2 1 1 3 3 3 3 Prokaryotic RING finger family 4 zf-C3HC4_4 PF15227.6 ETO23932.1 - 3.8e-06 26.9 9.4 3.8e-06 26.9 9.4 2.9 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING U-box PF04564.15 ETO23932.1 - 0.0001 22.4 1.2 0.00023 21.3 0.1 2.2 3 0 0 3 3 1 1 U-box domain zf-WRNIP1_ubi PF18279.1 ETO23932.1 - 0.00035 21.0 11.6 0.012 16.2 1.3 3.6 3 0 0 3 3 3 1 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-RING_6 PF14835.6 ETO23932.1 - 0.00047 20.0 5.9 0.00047 20.0 5.9 2.2 2 0 0 2 2 2 1 zf-RING of BARD1-type protein zf-rbx1 PF12678.7 ETO23932.1 - 0.0026 18.0 8.8 0.0026 18.0 8.8 3.5 2 2 1 3 3 3 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ETO23932.1 - 0.017 14.9 13.0 0.031 14.1 2.9 3.4 3 0 0 3 3 3 0 RING/Ubox like zinc-binding domain Zn-C2H2_12 PF18112.1 ETO23932.1 - 0.019 15.4 9.1 0.51 10.8 0.4 3.7 3 0 0 3 3 3 0 Autophagy receptor zinc finger-C2H2 domain zf-Di19 PF05605.12 ETO23932.1 - 0.022 15.1 18.0 0.19 12.1 0.9 3.9 2 1 1 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Paf1 PF03985.13 ETO23932.1 - 0.025 13.6 8.6 0.035 13.1 8.6 1.2 1 0 0 1 1 1 0 Paf1 Sgf11 PF08209.11 ETO23932.1 - 0.12 12.0 5.3 2.3 7.9 0.1 3.4 3 0 0 3 3 3 0 Sgf11 (transcriptional regulation protein) UBZ_FAAP20 PF15750.5 ETO23932.1 - 0.16 11.9 9.6 2.5 8.1 0.1 3.6 3 0 0 3 3 3 0 Ubiquitin-binding zinc-finger zf-ANAPC11 PF12861.7 ETO23932.1 - 0.17 12.0 9.4 1 9.4 5.2 2.9 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger zinc-ribbons_6 PF07191.12 ETO23932.1 - 0.42 10.6 17.5 0.74 9.8 7.3 2.6 2 0 0 2 2 2 0 zinc-ribbons zf_UBZ PF18439.1 ETO23932.1 - 0.57 9.8 8.2 5.6 6.6 0.1 4.1 4 0 0 4 4 3 0 Ubiquitin-Binding Zinc Finger DZR PF12773.7 ETO23932.1 - 1.4 9.0 15.3 0.48 10.5 6.6 2.8 2 1 0 2 2 2 0 Double zinc ribbon DNA_ligase_ZBD PF03119.16 ETO23932.1 - 2.6 8.1 6.0 18 5.5 0.1 3.4 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Gti1_Pac2 PF09729.9 ETO23932.1 - 2.7 8.0 10.6 4.5 7.3 10.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family zf-RING_10 PF16685.5 ETO23932.1 - 3.7 7.8 15.2 0.2 11.8 8.9 2.2 2 0 0 2 2 2 0 zinc RING finger of MSL2 YacG PF03884.14 ETO23932.1 - 7 6.5 14.1 9.3 6.1 0.7 3.8 3 0 0 3 3 3 0 DNA gyrase inhibitor YacG zf-ribbon_3 PF13248.6 ETO23932.1 - 8.4 6.0 18.1 0.19 11.2 0.7 4.0 5 0 0 5 5 5 0 zinc-ribbon domain tRNA_NucTran2_2 PF13735.6 ETO23933.1 - 0.042 13.8 0.9 0.042 13.8 0.9 2.1 1 1 1 2 2 2 0 tRNA nucleotidyltransferase domain 2 putative DnaJ PF00226.31 ETO23934.1 - 6.2e-14 51.9 0.1 1.3e-13 50.8 0.1 1.5 1 0 0 1 1 1 1 DnaJ domain CCDC168_N PF15804.5 ETO23934.1 - 0.001 19.0 0.8 0.0016 18.3 0.8 1.3 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 168 DUF2101 PF09874.9 ETO23934.1 - 0.0036 17.0 0.0 0.0056 16.4 0.0 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2101) TbpB_A PF17484.2 ETO23934.1 - 0.053 14.3 3.0 0.088 13.6 3.0 1.2 1 0 0 1 1 1 0 N-Lobe handle Tf-binding protein B DFP PF04127.15 ETO23936.1 - 0.0028 17.5 0.8 0.0065 16.3 0.8 1.6 1 0 0 1 1 1 1 DNA / pantothenate metabolism flavoprotein Baculo_PEP_C PF04513.12 ETO23936.1 - 0.0099 15.9 9.4 0.35 10.9 2.3 2.5 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus ER PF01133.17 ETO23936.1 - 0.45 10.6 5.4 0.75 9.9 1.0 3.1 2 1 1 3 3 3 0 Enhancer of rudimentary FAA_hydrolase_N PF09298.11 ETO23936.1 - 3.5 7.8 8.2 3.9 7.7 2.2 2.8 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal RPEL PF02755.15 ETO23937.1 - 8.5 6.2 15.7 9.2 6.1 0.0 6.0 7 0 0 7 7 7 0 RPEL repeat Ank_2 PF12796.7 ETO23938.1 - 9e-39 131.9 1.7 8.7e-14 51.9 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO23938.1 - 1.3e-31 108.5 0.3 3.9e-08 33.7 0.0 5.4 2 2 4 6 6 6 6 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO23938.1 - 1.4e-27 92.7 0.5 1.5e-07 31.1 0.0 7.0 7 0 0 7 7 7 4 Ankyrin repeat Ank PF00023.30 ETO23938.1 - 6.6e-25 86.4 0.6 8e-06 26.1 0.1 6.8 7 0 0 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 ETO23938.1 - 1.5e-22 79.3 0.6 1.8e-07 31.3 0.0 4.4 2 1 3 5 5 5 3 Ankyrin repeats (many copies) STATa_Ig PF18214.1 ETO23939.1 - 0.0026 17.7 0.8 0.006 16.6 0.8 1.7 1 0 0 1 1 1 1 STATa Immunoglobulin-like domain Alpha_kinase PF02816.18 ETO23941.1 - 1e-07 32.3 1.0 1.8e-07 31.5 0.0 1.8 2 1 0 2 2 2 1 Alpha-kinase family NAD_binding_6 PF08030.12 ETO23941.1 - 0.039 14.1 1.2 0.075 13.1 0.7 1.7 2 0 0 2 2 2 0 Ferric reductase NAD binding domain SHOCT PF09851.9 ETO23941.1 - 0.18 11.6 1.5 0.31 10.9 0.1 2.0 2 0 0 2 2 2 0 Short C-terminal domain OAD_gamma PF04277.13 ETO23942.1 - 0.24 12.0 1.4 0.34 11.5 1.4 1.2 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Kelch_4 PF13418.6 ETO23945.1 - 5e-06 26.4 6.0 0.32 11.1 0.1 5.0 5 2 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO23945.1 - 8.9e-06 25.8 11.0 0.019 15.2 0.4 5.4 3 1 2 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO23945.1 - 1.3e-05 25.4 3.1 0.082 13.2 0.0 4.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO23945.1 - 6e-05 22.9 6.7 0.38 10.8 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO23945.1 - 0.00094 18.7 3.4 16 5.2 0.3 5.3 5 1 0 5 5 5 1 Kelch motif Pkinase PF00069.25 ETO23946.1 - 3.7e-15 56.0 0.5 6.2e-15 55.3 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain PH PF00169.29 ETO23946.1 - 1.7e-13 51.0 1.2 1.7e-13 51.0 1.2 1.8 2 0 0 2 2 2 1 PH domain Pkinase_Tyr PF07714.17 ETO23946.1 - 3.1e-08 33.2 0.0 5.7e-08 32.4 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase PH_13 PF16652.5 ETO23946.1 - 1.3e-06 28.3 1.2 1e-05 25.4 0.3 2.2 1 1 1 2 2 2 1 Pleckstrin homology domain PH_11 PF15413.6 ETO23946.1 - 0.0012 19.2 7.0 0.003 18.0 2.5 2.8 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ETO23946.1 - 0.0086 16.3 0.6 0.0086 16.3 0.6 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 ETO23946.1 - 0.015 15.6 0.1 0.033 14.5 0.1 1.6 1 0 0 1 1 1 0 Pleckstrin homology domain PH_16 PF17838.1 ETO23946.1 - 0.02 14.7 0.8 0.046 13.6 0.8 1.6 1 0 0 1 1 1 0 PH domain TaqI_C PF12950.7 ETO23946.1 - 0.18 11.9 1.4 0.33 11.0 1.4 1.8 1 1 0 1 1 1 0 TaqI-like C-terminal specificity domain FAM176 PF14851.6 ETO23947.1 - 0.051 13.2 0.0 0.16 11.6 0.0 1.8 1 0 0 1 1 1 0 FAM176 family DUF2207 PF09972.9 ETO23947.1 - 0.092 11.5 0.7 0.45 9.2 0.0 1.9 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Pet100 PF09803.9 ETO23948.1 - 3 8.4 6.1 0.88 10.1 2.5 2.0 2 0 0 2 2 2 0 Pet100 60KD_IMP PF02096.20 ETO23948.1 - 7.6 6.4 6.3 1.7 8.5 1.9 2.0 2 0 0 2 2 2 0 60Kd inner membrane protein DUF1682 PF07946.14 ETO23948.1 - 7.7 5.6 14.2 22 4.2 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1682) Aldo_ket_red PF00248.21 ETO23949.1 - 1.8e-27 96.3 0.0 3.1e-27 95.6 0.0 1.4 1 1 0 1 1 1 1 Aldo/keto reductase family Avl9 PF09794.9 ETO23949.1 - 0.068 11.9 0.0 1.2 7.7 0.0 2.0 1 1 1 2 2 2 0 Transport protein Avl9 Clathrin PF00637.20 ETO23949.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.3 1 0 0 1 1 1 0 Region in Clathrin and VPS Prenyltrans PF00432.21 ETO23950.1 - 6.4e-14 51.4 5.5 6.7e-08 32.1 0.0 4.1 4 0 0 4 4 4 2 Prenyltransferase and squalene oxidase repeat Ytp1 PF10355.9 ETO23950.1 - 0.085 12.1 0.0 0.096 11.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (Ytp1) ApoB100_C PF12491.8 ETO23950.1 - 0.28 11.2 2.2 5 7.2 0.0 3.1 3 0 0 3 3 3 0 Apolipoprotein B100 C terminal Pkinase PF00069.25 ETO23951.1 - 0.00023 20.6 0.0 0.00044 19.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain EMC3_TMCO1 PF01956.16 ETO23954.1 - 0.00013 21.7 1.3 0.00036 20.3 0.1 1.9 2 0 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like DUF4834 PF16118.5 ETO23954.1 - 0.00095 20.1 1.6 0.0018 19.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Ureide_permease PF07168.11 ETO23954.1 - 0.0036 16.1 0.0 0.0057 15.5 0.0 1.3 1 0 0 1 1 1 1 Ureide permease S1FA PF04689.13 ETO23954.1 - 0.013 15.6 2.7 1.3 9.2 0.0 2.3 2 0 0 2 2 2 0 DNA binding protein S1FA Connexin PF00029.19 ETO23954.1 - 0.014 15.2 2.1 0.028 14.2 0.4 1.9 2 0 0 2 2 2 0 Connexin MRJP PF03022.16 ETO23954.1 - 0.023 14.0 0.4 0.023 14.0 0.4 1.6 2 0 0 2 2 2 0 Major royal jelly protein NicO PF03824.16 ETO23954.1 - 0.033 13.5 0.0 0.051 12.9 0.0 1.2 1 0 0 1 1 1 0 High-affinity nickel-transport protein EphA2_TM PF14575.6 ETO23954.1 - 0.04 14.8 0.8 0.35 11.8 0.2 2.2 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ctr PF04145.15 ETO23954.1 - 0.048 14.3 0.3 0.12 13.0 0.0 1.7 2 0 0 2 2 2 0 Ctr copper transporter family 7TM_GPCR_Srv PF10323.9 ETO23954.1 - 0.053 12.9 0.1 0.1 12.0 0.1 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv OATP PF03137.20 ETO23954.1 - 0.072 11.4 0.1 0.13 10.5 0.0 1.4 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family SVM_signal PF12113.8 ETO23954.1 - 0.11 12.5 0.3 0.23 11.4 0.3 1.5 1 0 0 1 1 1 0 SVM protein signal sequence zf-C3HC4_2 PF13923.6 ETO23955.1 - 2.7e-06 27.1 13.7 6.7e-06 25.8 13.7 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO23955.1 - 0.0073 16.1 13.9 0.014 15.3 13.9 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO23955.1 - 0.011 15.6 15.7 0.011 15.6 15.7 2.0 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO23955.1 - 0.019 15.3 12.0 0.019 15.3 12.0 1.7 2 0 0 2 2 2 0 Ring finger domain zf-RING_UBOX PF13445.6 ETO23955.1 - 0.3 11.1 10.2 0.72 9.9 10.2 1.7 1 0 0 1 1 1 0 RING-type zinc-finger WD40 PF00400.32 ETO23957.1 - 3e-35 119.6 29.3 9.1e-07 29.5 0.7 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23957.1 - 2.7e-09 37.2 3.7 0.26 11.6 0.0 5.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO23957.1 - 1.3e-05 25.8 2.8 1.3e-05 25.8 2.8 2.9 3 0 0 3 3 3 1 TRAF-type zinc finger TSC22 PF01166.18 ETO23957.1 - 0.0079 16.5 0.9 0.032 14.5 0.5 2.3 2 0 0 2 2 2 1 TSC-22/dip/bun family GIT_CC PF16559.5 ETO23957.1 - 0.11 12.4 3.8 0.27 11.1 3.8 1.7 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor ZapB PF06005.12 ETO23957.1 - 0.4 11.1 5.8 1.2 9.7 5.8 1.9 1 1 0 1 1 1 0 Cell division protein ZapB zf-RING-like PF08746.11 ETO23957.1 - 1.2 9.5 5.2 0.83 10.0 0.2 3.1 2 0 0 2 2 2 0 RING-like domain Pkinase PF00069.25 ETO23959.1 - 0.00021 20.7 0.4 0.00046 19.6 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase PF00069.25 ETO23961.1 - 1e-37 130.0 1.3 2.4e-30 105.8 0.0 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23961.1 - 7e-20 71.4 4.3 3.4e-18 65.9 0.0 3.0 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO23961.1 - 1.7e-08 33.8 2.0 1.6e-07 30.7 0.0 2.4 2 1 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ETO23961.1 - 0.00071 19.0 0.3 0.0023 17.3 0.0 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RB_A PF01858.17 ETO23961.1 - 0.012 15.4 14.5 0.13 12.1 10.6 2.8 2 1 0 2 2 2 0 Retinoblastoma-associated protein A domain APH PF01636.23 ETO23961.1 - 0.031 14.2 2.0 0.14 12.1 0.1 2.4 2 1 1 3 3 3 0 Phosphotransferase enzyme family FAA_hydrolase_N PF09298.11 ETO23961.1 - 0.3 11.3 3.6 4.1 7.6 1.1 2.4 1 1 1 2 2 2 0 Fumarylacetoacetase N-terminal Tox-SHH PF15652.6 ETO23961.1 - 9.6 7.2 10.5 0.16 12.9 1.9 2.5 3 0 0 3 3 3 0 HNH/Endo VII superfamily toxin with a SHH signature DUF4199 PF13858.6 ETO23964.1 - 0.058 13.8 3.9 0.11 12.9 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) Hydin_ADK PF17213.3 ETO23965.1 - 5.3 7.3 12.4 7.3 6.8 12.4 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain XRCC4 PF06632.12 ETO23965.1 - 6.5 5.5 18.6 8.6 5.1 18.6 1.2 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Kelch_4 PF13418.6 ETO23967.1 - 3.1e-22 78.3 0.0 7.7e-12 45.0 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO23967.1 - 4.9e-22 77.7 0.0 1.2e-09 38.3 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO23967.1 - 1.1e-19 69.9 0.3 3.1e-09 36.8 0.0 2.2 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO23967.1 - 4.5e-17 61.4 0.1 2.2e-08 33.5 0.1 2.2 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO23967.1 - 3.2e-14 52.5 0.2 3e-06 27.1 0.0 2.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO23967.1 - 2.5e-10 39.9 0.3 0.00031 20.6 0.0 2.3 2 0 0 2 2 2 2 Kelch motif B12-binding PF02310.19 ETO23968.1 - 3.2e-12 46.5 0.7 4.7e-09 36.3 0.0 2.1 2 0 0 2 2 2 2 B12 binding domain YoqO PF14037.6 ETO23968.1 - 0.024 15.1 0.2 0.036 14.6 0.2 1.2 1 0 0 1 1 1 0 YoqO-like protein WD40 PF00400.32 ETO23969.1 - 1.2e-09 38.6 1.4 0.47 11.4 0.0 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23969.1 - 6.3e-05 23.2 0.1 1 9.7 0.0 3.7 2 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain CRT10 PF08728.10 ETO23969.1 - 0.0048 15.1 0.1 0.027 12.7 0.1 1.8 2 0 0 2 2 2 1 CRT10 PQQ_3 PF13570.6 ETO23969.1 - 0.015 15.7 0.2 2.4 8.8 0.0 3.5 3 0 0 3 3 3 0 PQQ-like domain Abhydrolase_1 PF00561.20 ETO23970.1 - 1.2e-10 41.5 0.0 1.6e-10 41.1 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO23970.1 - 0.00017 22.3 0.0 0.00023 21.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETO23970.1 - 0.021 14.1 0.0 0.025 13.8 0.0 1.1 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ETO23970.1 - 0.072 12.9 0.0 0.096 12.5 0.0 1.2 1 0 0 1 1 1 0 alpha/beta hydrolase fold PRELI PF04707.14 ETO23971.1 - 0.05 13.4 0.2 1 9.1 0.0 2.4 2 0 0 2 2 2 0 PRELI-like family IFS PF16718.5 ETO23972.1 - 0.007 16.5 1.9 0.014 15.5 1.9 1.4 1 0 0 1 1 1 1 Immunity factor for SPN VHP PF02209.19 ETO23973.1 - 0.029 14.4 1.3 0.092 12.8 0.5 2.2 2 0 0 2 2 2 0 Villin headpiece domain SDA1 PF05285.12 ETO23974.1 - 0.053 13.0 15.6 0.057 12.8 15.6 1.1 1 0 0 1 1 1 0 SDA1 FAM76 PF16046.5 ETO23974.1 - 1.9 7.8 7.3 1.9 7.7 7.3 1.2 1 0 0 1 1 1 0 FAM76 protein Carboxyl_trans PF01039.22 ETO23976.1 - 1.4e-119 400.0 0.0 5.4e-114 381.5 0.0 2.4 2 0 0 2 2 2 2 Carboxyl transferase domain ACC_central PF08326.12 ETO23976.1 - 8.5e-88 295.4 0.6 7.3e-46 156.7 1.8 2.3 1 1 1 2 2 2 2 Acetyl-CoA carboxylase, central region CPSase_L_D2 PF02786.17 ETO23976.1 - 2.4e-48 164.5 0.0 4.6e-48 163.5 0.0 1.4 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain Biotin_carb_C PF02785.19 ETO23976.1 - 7.1e-26 90.4 0.0 3.1e-25 88.4 0.0 2.2 2 0 0 2 2 2 1 Biotin carboxylase C-terminal domain Biotin_carb_N PF00289.22 ETO23976.1 - 1.4e-21 77.1 0.0 1.2e-20 74.1 0.0 2.4 2 0 0 2 2 2 1 Biotin carboxylase, N-terminal domain Biotin_lipoyl PF00364.22 ETO23976.1 - 3.2e-10 39.7 0.1 6.3e-10 38.7 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme ATP-grasp_3 PF02655.14 ETO23976.1 - 5.9e-05 23.2 0.1 0.0002 21.4 0.1 1.9 1 0 0 1 1 1 1 ATP-grasp domain Biotin_lipoyl_2 PF13533.6 ETO23976.1 - 0.00015 21.5 0.3 0.0019 18.0 0.0 2.8 3 0 0 3 3 3 1 Biotin-lipoyl like Dala_Dala_lig_C PF07478.13 ETO23976.1 - 0.00052 19.6 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 D-ala D-ala ligase C-terminus ATP-grasp PF02222.22 ETO23976.1 - 0.00072 19.2 0.0 0.0016 18.1 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 ETO23976.1 - 0.06 13.1 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 ATP-grasp in the biosynthetic pathway with Ter operon GCV_H PF01597.19 ETO23976.1 - 0.11 12.3 0.0 0.33 10.8 0.0 1.7 1 0 0 1 1 1 0 Glycine cleavage H-protein DUF641 PF04859.12 ETO23976.1 - 1.1 9.6 10.9 0.25 11.7 4.7 2.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Utp14 PF04615.13 ETO23977.1 - 9.9e-44 150.1 53.2 4.2e-27 95.1 32.3 2.1 1 1 1 2 2 2 2 Utp14 protein BUD22 PF09073.10 ETO23978.1 - 4.1e-05 23.1 23.4 5.7e-05 22.6 23.4 1.2 1 0 0 1 1 1 1 BUD22 EFG_II PF14492.6 ETO23978.1 - 0.00021 21.3 0.0 0.00059 19.9 0.0 1.8 1 0 0 1 1 1 1 Elongation Factor G, domain II Nop14 PF04147.12 ETO23978.1 - 0.0003 19.2 30.4 0.00042 18.7 30.4 1.1 1 0 0 1 1 1 1 Nop14-like family SDA1 PF05285.12 ETO23978.1 - 0.0065 15.9 27.7 0.0089 15.5 27.7 1.2 1 0 0 1 1 1 1 SDA1 SAPS PF04499.15 ETO23978.1 - 0.1 11.4 13.1 0.077 11.8 11.7 1.6 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein DUF4407 PF14362.6 ETO23978.1 - 0.39 10.0 8.5 0.55 9.5 8.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TIMELESS_C PF05029.13 ETO23978.1 - 0.94 8.5 27.7 1.4 8.0 27.7 1.1 1 0 0 1 1 1 0 Timeless protein C terminal region Paf1 PF03985.13 ETO23978.1 - 1.1 8.2 32.2 2.3 7.1 32.2 1.5 1 0 0 1 1 1 0 Paf1 TFIIF_alpha PF05793.12 ETO23978.1 - 2.9 6.4 34.0 0.15 10.6 28.9 1.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Rtf2 PF04641.12 ETO23978.1 - 2.9 7.2 14.7 1.9 7.7 12.2 1.9 2 0 0 2 2 2 0 Rtf2 RING-finger ALMT PF11744.8 ETO23978.1 - 4.5 6.0 5.7 6.8 5.4 5.7 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter Peptidase_S64 PF08192.11 ETO23978.1 - 5 5.5 11.2 6.7 5.1 11.2 1.2 1 0 0 1 1 1 0 Peptidase family S64 EFG_C PF00679.24 ETO23979.1 - 3.3e-10 39.9 0.0 1.4e-06 28.3 0.0 2.6 3 0 0 3 3 3 2 Elongation factor G C-terminus EFG_IV PF03764.18 ETO23979.1 - 0.00034 20.4 0.0 0.00073 19.3 0.0 1.6 1 0 0 1 1 1 1 Elongation factor G, domain IV FAM176 PF14851.6 ETO23979.1 - 0.0081 15.8 0.7 0.014 15.0 0.7 1.3 1 0 0 1 1 1 1 FAM176 family CENP-B_dimeris PF09026.10 ETO23979.1 - 0.018 15.4 3.1 0.039 14.3 3.1 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Mrpl_C PF18502.1 ETO23980.1 - 0.9 9.8 4.2 0.49 10.7 0.2 2.6 2 2 1 3 3 3 0 54S ribosomal protein L8 C-terminal domain PRP1_N PF06424.12 ETO23981.1 - 0.006 17.0 8.7 0.006 17.0 8.7 3.0 2 1 1 3 3 3 1 PRP1 splicing factor, N-terminal DUF4065 PF13274.6 ETO23981.1 - 0.13 13.2 9.7 0.079 13.9 3.1 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4065) Ctr PF04145.15 ETO23981.1 - 1.7 9.3 9.9 0.13 12.8 0.8 2.5 1 1 1 2 2 2 0 Ctr copper transporter family Tektin PF03148.14 ETO23982.1 - 0.01 14.6 3.4 0.49 9.1 0.1 2.0 2 0 0 2 2 2 0 Tektin family Peptidase_M15_3 PF08291.11 ETO23982.1 - 0.011 15.8 0.3 0.017 15.2 0.3 1.4 1 1 0 1 1 1 0 Peptidase M15 PI3K_P85_iSH2 PF16454.5 ETO23982.1 - 0.018 14.6 5.6 0.052 13.1 2.5 2.0 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Sec8_exocyst PF04048.14 ETO23982.1 - 0.022 14.6 4.2 1.4 8.8 0.7 2.2 2 0 0 2 2 2 0 Sec8 exocyst complex component specific domain DUF3584 PF12128.8 ETO23982.1 - 0.025 12.1 5.5 0.028 12.0 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) T3SS_needle_E PF08988.10 ETO23982.1 - 0.036 14.2 0.9 4.3 7.6 0.1 2.3 2 0 0 2 2 2 0 Type III secretion system, cytoplasmic E component of needle KASH_CCD PF14662.6 ETO23982.1 - 0.047 13.5 7.3 0.078 12.8 7.3 1.3 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH THOC7 PF05615.13 ETO23982.1 - 0.05 13.9 5.4 0.12 12.6 2.2 2.0 2 0 0 2 2 2 0 Tho complex subunit 7 Raftlin PF15250.6 ETO23982.1 - 0.051 12.3 3.2 0.057 12.2 3.2 1.2 1 1 0 1 1 1 0 Raftlin Fib_alpha PF08702.10 ETO23982.1 - 0.063 13.5 6.1 3.2 7.9 5.6 2.1 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family DUF745 PF05335.13 ETO23982.1 - 0.095 12.4 4.9 0.49 10.1 1.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF745) TPR_MLP1_2 PF07926.12 ETO23982.1 - 0.1 12.7 8.3 0.84 9.7 4.2 2.1 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein CREPT PF16566.5 ETO23982.1 - 0.14 12.3 4.2 7.2 6.8 2.5 2.1 2 0 0 2 2 2 0 Cell-cycle alteration and expression-elevated protein in tumour DASH_Spc19 PF08287.11 ETO23982.1 - 0.18 11.7 6.2 0.3 11.0 6.2 1.4 1 1 0 1 1 1 0 Spc19 Prefoldin_2 PF01920.20 ETO23982.1 - 0.27 11.2 9.5 2.2 8.3 0.1 2.4 2 1 0 2 2 2 0 Prefoldin subunit Fzo_mitofusin PF04799.13 ETO23982.1 - 0.28 10.7 4.1 0.36 10.4 0.1 2.0 2 0 0 2 2 2 0 fzo-like conserved region DUF1682 PF07946.14 ETO23982.1 - 0.34 10.1 6.0 0.46 9.6 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) TBCA PF02970.16 ETO23982.1 - 0.37 11.1 9.3 0.47 10.8 6.4 2.0 2 0 0 2 2 2 0 Tubulin binding cofactor A Prefoldin PF02996.17 ETO23982.1 - 0.49 10.3 10.3 1.7 8.6 0.0 2.3 2 0 0 2 2 2 0 Prefoldin subunit ALMT PF11744.8 ETO23982.1 - 0.65 8.8 3.3 0.75 8.6 3.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Mod_r PF07200.13 ETO23982.1 - 0.76 9.9 7.6 5.3 7.1 7.6 1.9 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein RPW8 PF05659.11 ETO23982.1 - 1.3 8.7 7.6 9.5 5.9 5.2 2.2 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 ISG65-75 PF11727.8 ETO23982.1 - 1.8 7.7 11.5 1.1 8.5 8.3 1.9 1 1 1 2 2 2 0 Invariant surface glycoprotein SseC PF04888.12 ETO23982.1 - 3.7 7.1 10.9 2.4 7.7 0.1 2.1 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Spc7 PF08317.11 ETO23982.1 - 3.9 6.3 11.5 16 4.3 11.5 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein Seryl_tRNA_N PF02403.22 ETO23982.1 - 3.9 7.7 13.3 8 6.7 9.0 2.3 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF4407 PF14362.6 ETO23982.1 - 4.2 6.6 6.5 12 5.2 6.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4200 PF13863.6 ETO23982.1 - 7.1 7.1 15.6 41 4.6 11.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) TMPIT PF07851.13 ETO23982.1 - 8.5 5.5 6.2 22 4.2 6.2 1.6 1 1 0 1 1 1 0 TMPIT-like protein WD40 PF00400.32 ETO23983.1 - 7.9e-61 200.6 20.3 2.8e-10 40.6 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO23983.1 - 2.2e-18 66.3 0.3 4.1e-06 27.0 0.0 5.3 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO23983.1 - 2.8e-13 49.5 0.5 0.00081 18.5 0.1 4.9 1 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO23983.1 - 7.1e-07 28.9 2.5 0.26 10.6 0.1 3.4 1 1 2 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO23983.1 - 9.5e-07 28.9 0.7 0.00017 21.6 0.1 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO23983.1 - 0.00018 20.3 3.3 0.43 9.2 0.5 4.2 2 1 1 3 3 3 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO23983.1 - 0.0014 18.7 1.1 18 5.4 0.0 4.2 1 1 4 5 5 5 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO23983.1 - 0.0027 16.3 0.1 0.041 12.4 0.0 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain DUF1258 PF06869.12 ETO23983.1 - 0.008 15.7 0.5 0.17 11.3 0.0 2.9 1 1 1 3 3 3 1 Protein of unknown function (DUF1258) TMEM107 PF14995.6 ETO23983.1 - 0.0086 16.5 1.7 0.023 15.1 1.1 1.9 2 0 0 2 2 2 1 Transmembrane protein Proteasome_A_N PF10584.9 ETO23983.1 - 0.0096 15.6 0.6 14 5.5 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 ETO23983.1 - 0.012 14.6 0.9 2.4 7.0 0.1 3.3 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Frtz PF11768.8 ETO23983.1 - 0.014 13.8 0.0 0.053 11.8 0.0 1.9 1 1 2 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO23983.1 - 0.045 13.7 4.9 3.2 7.8 0.2 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF3135 PF11333.8 ETO23983.1 - 0.12 12.6 0.0 5.9 7.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3135) RPEL PF02755.15 ETO23984.1 - 6.3e-10 38.4 6.9 0.0028 17.3 2.0 4.0 3 1 0 3 3 3 3 RPEL repeat C2 PF00168.30 ETO23985.1 - 2.3e-09 37.5 0.1 7.4e-09 35.8 0.0 1.9 2 0 0 2 2 2 1 C2 domain DUF4497 PF14924.6 ETO23985.1 - 0.073 13.6 0.1 1.3 9.5 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4497) CPSF100_C PF13299.6 ETO23985.1 - 3.4 7.8 8.1 0.58 10.3 3.4 2.0 1 1 1 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1450 PF07293.11 ETO23986.1 - 0.0045 16.8 0.2 0.009 15.8 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1450) SR-25 PF10500.9 ETO23987.1 - 0.49 10.0 8.2 0.98 9.0 8.2 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CAP_GLY PF01302.25 ETO23988.1 - 3.4e-41 139.1 5.1 7.7e-21 73.9 0.3 2.5 2 0 0 2 2 2 2 CAP-Gly domain PH_10 PF15411.6 ETO23988.1 - 0.14 12.4 4.4 0.64 10.3 2.0 2.5 2 0 0 2 2 2 0 Pleckstrin homology domain Hydin_ADK PF17213.3 ETO23988.1 - 9.4 6.5 9.8 15 5.8 0.1 2.7 3 0 0 3 3 3 0 Hydin Adenylate kinase-like domain Pkinase PF00069.25 ETO23989.1 - 1.1e-71 241.4 0.0 1.7e-71 240.7 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO23989.1 - 3.4e-33 115.0 0.0 5.7e-33 114.3 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Myosin_TH1 PF06017.13 ETO23989.1 - 1.1e-14 54.5 4.2 2.5e-14 53.4 4.2 1.5 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Pkinase_C PF00433.24 ETO23989.1 - 0.00031 21.4 0.1 0.00081 20.0 0.1 1.7 1 0 0 1 1 1 1 Protein kinase C terminal domain Kinase-like PF14531.6 ETO23989.1 - 0.0011 18.4 0.1 0.037 13.4 0.0 2.3 2 0 0 2 2 2 1 Kinase-like Kdo PF06293.14 ETO23989.1 - 0.0091 15.4 0.0 0.018 14.4 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family TT_ORF2 PF02957.15 ETO23989.1 - 0.013 16.4 0.4 0.031 15.2 0.4 1.6 1 0 0 1 1 1 0 TT viral ORF2 Glyco_transf_8 PF01501.20 ETO23990.1 - 7.2e-06 25.7 0.1 7.2e-06 25.7 0.1 2.1 2 1 0 2 2 2 1 Glycosyl transferase family 8 Polysacc_synt PF01943.17 ETO23990.1 - 0.11 11.9 0.3 0.15 11.4 0.3 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Ras PF00071.22 ETO23991.1 - 3.5e-08 33.2 0.4 0.0097 15.5 0.1 2.8 2 1 0 2 2 2 2 Ras family Arf PF00025.21 ETO23991.1 - 0.032 13.7 0.4 14 5.1 0.1 3.1 2 1 0 2 2 2 0 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO23991.1 - 0.36 10.3 4.1 0.77 9.3 4.1 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Vps62 PF06101.11 ETO23992.1 - 3.2e-06 25.7 1.1 2.6e-05 22.8 1.1 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 FNIP_C PF14638.6 ETO23994.1 - 0.071 12.7 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Folliculin-interacting protein C-terminus Beach PF02138.18 ETO23995.1 - 5.3e-113 377.0 0.3 7.7e-113 376.5 0.3 1.1 1 0 0 1 1 1 1 Beige/BEACH domain Dyp_perox PF04261.12 ETO23995.1 - 0.19 10.7 0.2 0.3 10.1 0.2 1.2 1 0 0 1 1 1 0 Dyp-type peroxidase family baeRF_family12 PF18856.1 ETO23997.1 - 0.0084 16.7 0.7 0.0084 16.7 0.7 2.1 2 0 0 2 2 2 1 Bacterial archaeo-eukaryotic release factor family 12 DUF5523 PF17661.1 ETO23997.1 - 0.11 12.1 14.2 0.02 14.6 8.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) DUF3439 PF11921.8 ETO23997.1 - 0.2 11.6 6.4 0.35 10.8 6.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Rxt3 PF08642.10 ETO23997.1 - 0.23 12.2 0.2 0.23 12.2 0.2 2.7 2 1 0 2 2 2 0 Histone deacetylation protein Rxt3 Paf1 PF03985.13 ETO23997.1 - 0.7 8.8 15.2 0.069 12.1 7.7 2.3 2 0 0 2 2 2 0 Paf1 SSP160 PF06933.11 ETO23997.1 - 0.78 7.9 10.2 1 7.5 10.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FAM176 PF14851.6 ETO23997.1 - 5.1 6.7 17.0 0.52 10.0 4.8 2.6 2 1 0 2 2 2 0 FAM176 family TMEM51 PF15345.6 ETO23997.1 - 6 6.6 8.0 11 5.8 1.7 2.2 2 0 0 2 2 2 0 Transmembrane protein 51 ubiquitin PF00240.23 ETO23998.1 - 5.7e-07 29.2 0.1 1.1e-06 28.3 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_2 PF14560.6 ETO23998.1 - 2.7e-06 27.7 0.1 5.2e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO23998.1 - 0.032 14.2 0.0 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain UN_NPL4 PF11543.8 ETO23998.1 - 0.076 13.5 0.2 0.13 12.7 0.2 1.4 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 zf-C3HC4_3 PF13920.6 ETO23999.1 - 0.00028 20.7 15.9 0.00062 19.6 15.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO23999.1 - 0.0021 18.3 20.7 0.0021 18.3 20.7 1.7 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO23999.1 - 0.0022 17.8 19.9 0.0046 16.8 19.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ETO23999.1 - 0.004 17.0 6.1 0.0072 16.2 6.1 1.4 1 0 0 1 1 1 1 zf-RING of BARD1-type protein CRA PF06589.11 ETO23999.1 - 0.0045 17.1 7.5 0.0072 16.4 0.2 2.4 2 0 0 2 2 2 1 Circumsporozoite-related antigen (CRA) CcmH PF03918.14 ETO23999.1 - 0.11 11.8 1.1 11 5.4 0.2 2.6 2 0 0 2 2 2 0 Cytochrome C biogenesis protein SID-1_RNA_chan PF13965.6 ETO23999.1 - 0.21 9.9 4.7 1.6 7.1 4.7 1.9 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 zf-C3HC4_4 PF15227.6 ETO23999.1 - 1.4 9.1 15.7 7.7 6.8 16.1 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING Prok-RING_4 PF14447.6 ETO23999.1 - 1.8 8.5 16.5 4.5 7.2 16.5 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Endostatin PF06482.11 ETO24000.1 - 8.9 5.7 12.1 9.8 5.5 12.1 1.1 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin DEP PF00610.21 ETO24001.1 - 9.6e-10 38.4 0.0 2.5e-09 37.1 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pox_A28 PF04584.14 ETO24002.1 - 0.036 14.2 0.4 0.064 13.4 0.1 1.5 1 1 0 1 1 1 0 Poxvirus A28 family CBM_25 PF03423.13 ETO24002.1 - 0.17 12.2 0.2 0.35 11.1 0.2 1.5 1 0 0 1 1 1 0 Carbohydrate binding domain (family 25) CENP-B_dimeris PF09026.10 ETO24002.1 - 4.9 7.6 11.5 2.2 8.7 7.9 2.1 3 0 0 3 3 3 0 Centromere protein B dimerisation domain RNA_pol_3_Rpc31 PF11705.8 ETO24002.1 - 8.5 6.6 10.6 10 6.3 10.6 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 SpoIIIAH PF12685.7 ETO24003.1 - 5.2 6.8 19.3 0.66 9.8 14.5 1.8 2 0 0 2 2 2 0 SpoIIIAH-like protein RhoGAP PF00620.27 ETO24004.1 - 8.8e-07 28.9 0.7 2e-06 27.7 0.7 1.5 1 1 0 1 1 1 1 RhoGAP domain Pro_CA PF00484.19 ETO24004.1 - 0.069 13.4 0.1 0.11 12.7 0.1 1.3 1 0 0 1 1 1 0 Carbonic anhydrase EMP70 PF02990.16 ETO24005.1 - 5e-58 197.1 23.3 6.2e-58 196.7 23.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 MFS_2 PF13347.6 ETO24006.1 - 4.3e-08 32.2 1.1 9e-08 31.1 0.0 1.9 2 1 0 2 2 2 1 MFS/sugar transport protein MFS_1 PF07690.16 ETO24006.1 - 2.9e-07 29.8 4.0 6.1e-07 28.7 3.7 1.6 1 1 0 1 1 1 1 Major Facilitator Superfamily DUF4366 PF14283.6 ETO24007.1 - 0.013 15.5 9.6 0.014 15.5 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4366) DUF572 PF04502.13 ETO24007.1 - 0.33 10.6 7.0 0.41 10.2 7.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 ETO24007.1 - 0.76 8.3 5.2 0.81 8.2 5.2 1.0 1 0 0 1 1 1 0 Utp14 protein Ndc1_Nup PF09531.10 ETO24007.1 - 0.88 8.2 11.5 1.1 7.9 11.5 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 ETO24007.1 - 0.89 8.7 24.0 1.1 8.4 24.0 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein PRCC PF10253.9 ETO24007.1 - 1.1 10.0 14.2 1.6 9.5 14.2 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting DUF4064 PF13273.6 ETO24007.1 - 1.1 9.5 0.0 1.1 9.5 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) MGC-24 PF05283.11 ETO24007.1 - 1.2 9.6 38.2 12 6.4 15.5 2.2 1 1 1 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Endomucin PF07010.12 ETO24007.1 - 1.7 8.6 39.8 2.7 7.9 39.8 1.3 1 0 0 1 1 1 0 Endomucin GREB1 PF15782.5 ETO24007.1 - 3.2 4.8 10.3 3.1 4.8 10.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Macoilin PF09726.9 ETO24007.1 - 4.8 5.6 7.0 5.3 5.5 7.0 1.1 1 0 0 1 1 1 0 Macoilin family Adeno_hexon PF01065.19 ETO24007.1 - 6.9 5.4 17.7 0.018 14.0 2.7 2.0 1 1 1 2 2 2 0 Hexon, adenovirus major coat protein, N-terminal domain zf-RING_2 PF13639.6 ETO24008.1 - 1.1e-09 38.5 9.9 1.1e-09 38.5 9.9 1.9 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO24008.1 - 2.6e-06 27.1 9.7 2.6e-06 27.1 9.7 2.5 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO24008.1 - 3e-06 27.4 13.5 3e-06 27.4 13.5 2.6 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO24008.1 - 7.6e-06 25.7 9.5 7.6e-06 25.7 9.5 2.2 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO24008.1 - 0.00036 20.2 7.9 0.00036 20.2 7.9 2.3 3 0 0 3 3 3 1 RING-like zinc finger zf-C3HC4_3 PF13920.6 ETO24008.1 - 0.00052 19.8 7.0 0.0012 18.6 7.0 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO24008.1 - 0.0031 17.4 8.9 0.0031 17.4 8.9 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ETO24008.1 - 0.16 12.1 13.2 0.17 12.0 10.2 2.6 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETO24008.1 - 0.65 9.7 16.4 0.077 12.6 11.0 2.3 1 1 0 2 2 2 0 Zinc-ribbon, C4HC2 type EMP70 PF02990.16 ETO24009.1 - 1.2e-21 77.0 0.2 1.9e-21 76.4 0.2 1.2 1 0 0 1 1 1 1 Endomembrane protein 70 AAA_11 PF13086.6 ETO24010.1 - 1.2e-63 215.4 0.3 2.3e-63 214.4 0.3 1.5 1 0 0 1 1 1 1 AAA domain AAA_12 PF13087.6 ETO24010.1 - 4.1e-28 98.4 0.3 1.2e-27 96.9 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETO24010.1 - 1e-10 41.7 0.0 1.2e-08 35.0 0.0 2.4 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETO24010.1 - 5.9e-09 36.4 0.2 1.7e-07 31.7 0.2 3.2 2 1 0 2 2 2 1 AAA domain AAA_23 PF13476.6 ETO24010.1 - 2.1e-06 28.4 0.8 2.1e-06 28.4 0.8 2.4 1 1 1 2 2 2 1 AAA domain DEAD PF00270.29 ETO24010.1 - 0.00014 21.7 0.4 0.0044 16.8 0.0 2.5 1 1 1 2 2 2 1 DEAD/DEAH box helicase Viral_helicase1 PF01443.18 ETO24010.1 - 0.00036 20.3 0.3 0.78 9.4 0.1 2.6 2 1 0 2 2 2 2 Viral (Superfamily 1) RNA helicase AAA_16 PF13191.6 ETO24010.1 - 0.00042 20.7 0.5 0.0019 18.6 0.5 2.1 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO24010.1 - 0.00098 19.4 0.8 0.046 14.0 0.0 3.0 2 1 0 2 2 2 1 AAA domain DUF2075 PF09848.9 ETO24010.1 - 0.0012 18.2 1.4 0.22 10.7 0.0 3.2 2 1 0 3 3 3 1 Uncharacterized conserved protein (DUF2075) AAA_24 PF13479.6 ETO24010.1 - 0.0016 18.2 1.4 0.0076 16.0 0.0 2.8 3 1 0 3 3 3 1 AAA domain ResIII PF04851.15 ETO24010.1 - 0.0025 17.8 0.9 0.0071 16.4 0.0 2.3 2 1 0 2 2 1 1 Type III restriction enzyme, res subunit UvrD-helicase PF00580.21 ETO24010.1 - 0.0043 16.6 2.0 0.026 14.1 0.5 2.6 1 1 2 3 3 3 1 UvrD/REP helicase N-terminal domain CENP-Q PF13094.6 ETO24010.1 - 0.0057 16.9 1.2 0.019 15.1 1.2 1.9 1 0 0 1 1 1 1 CENP-Q, a CENPA-CAD centromere complex subunit BST2 PF16716.5 ETO24010.1 - 0.014 15.9 4.6 0.044 14.4 4.6 1.8 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 Atg14 PF10186.9 ETO24010.1 - 0.016 14.3 0.5 0.031 13.4 0.5 1.5 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 AAA PF00004.29 ETO24010.1 - 0.018 15.5 3.4 0.18 12.2 3.4 2.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NTPase_1 PF03266.15 ETO24010.1 - 0.025 14.5 1.7 3.2 7.6 0.0 3.5 2 1 1 3 3 3 0 NTPase ATPase PF06745.13 ETO24010.1 - 0.033 13.5 0.2 0.11 11.9 0.0 1.9 2 0 0 2 2 2 0 KaiC AAA_33 PF13671.6 ETO24010.1 - 0.052 13.7 0.0 0.25 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO24010.1 - 0.066 13.8 0.8 0.95 10.0 0.1 2.9 2 1 0 2 2 2 0 AAA domain T2SSE PF00437.20 ETO24010.1 - 0.076 12.1 0.1 0.17 10.9 0.0 1.6 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF2526 PF10735.9 ETO24010.1 - 0.078 13.1 0.2 0.23 11.6 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2526) cobW PF02492.19 ETO24010.1 - 0.08 12.5 0.4 5.1 6.6 0.0 2.5 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain RNA_helicase PF00910.22 ETO24010.1 - 0.092 13.1 0.1 1.5 9.3 0.0 2.5 2 0 0 2 2 2 0 RNA helicase CDC27 PF09507.10 ETO24012.1 - 0.084 12.2 35.5 0.095 12.1 35.5 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIA PF03153.13 ETO24012.1 - 0.65 9.9 36.2 0.87 9.5 36.2 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Mitofilin PF09731.9 ETO24012.1 - 1.7 7.4 34.0 2.1 7.1 34.0 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein YjbH PF06082.11 ETO24012.1 - 2.5 6.8 20.2 3.3 6.4 20.2 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH CAC1F_C PF16885.5 ETO24012.1 - 3.3 7.3 24.6 4.1 7.0 24.6 1.2 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Thioredoxin_2 PF13098.6 ETO24013.1 - 0.13 12.7 0.2 0.25 11.8 0.2 1.5 1 0 0 1 1 1 0 Thioredoxin-like domain Patched PF02460.18 ETO24014.1 - 3.3e-12 45.4 9.7 4.3e-12 45.0 9.7 1.1 1 0 0 1 1 1 1 Patched family PAN_1 PF00024.26 ETO24014.1 - 0.023 14.7 10.9 0.066 13.2 2.7 2.4 2 0 0 2 2 2 0 PAN domain Bromo_TP_like PF17027.5 ETO24015.1 - 0.007 16.5 0.2 0.015 15.4 0.2 1.6 1 0 0 1 1 1 1 Histone-fold protein DUF1977 PF09320.11 ETO24017.1 - 1.1e-06 28.8 8.9 4.5e-06 26.9 8.9 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF1977) DUF5070 PF16802.5 ETO24017.1 - 0.042 13.8 0.3 0.064 13.2 0.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5070) MAS20 PF02064.15 ETO24017.1 - 0.068 13.3 4.2 0.16 12.1 4.2 1.5 1 0 0 1 1 1 0 MAS20 protein import receptor YfhO PF09586.10 ETO24017.1 - 0.2 9.8 3.0 0.28 9.3 3.0 1.2 1 0 0 1 1 1 0 Bacterial membrane protein YfhO SpoIIIAH PF12685.7 ETO24018.1 - 1.2 9.0 12.3 2.5 7.9 12.3 1.5 1 0 0 1 1 1 0 SpoIIIAH-like protein KRTAP PF11759.8 ETO24018.1 - 2 9.0 26.3 29 5.3 22.2 2.8 2 1 0 2 2 2 0 Keratin-associated matrix Presenilin PF01080.17 ETO24018.1 - 6.2 5.5 12.6 0.052 12.3 0.4 2.1 2 0 0 2 2 2 0 Presenilin Baseplate PF16774.5 ETO24020.1 - 0.22 11.4 3.8 6.6 6.6 1.2 2.1 2 0 0 2 2 2 0 Baseplate protein Ras PF00071.22 ETO24021.1 - 1e-24 87.0 0.3 1.5e-24 86.5 0.3 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETO24021.1 - 0.0047 16.4 0.1 0.0071 15.8 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family HA1 PF18239.1 ETO24021.1 - 0.014 15.2 0.0 0.021 14.7 0.0 1.3 1 0 0 1 1 1 0 Hemagglutinin I HA2 PF04408.23 ETO24022.1 - 6.4e-20 71.4 0.0 1.2e-19 70.6 0.0 1.4 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETO24022.1 - 9.9e-14 51.6 0.3 1.7e-12 47.7 0.1 2.8 2 1 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO24022.1 - 0.00083 19.2 0.2 0.0022 17.8 0.2 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase UPF0184 PF03670.13 ETO24022.1 - 0.023 15.1 0.1 0.055 13.9 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) Acetyltransf_1 PF00583.25 ETO24023.1 - 1.4e-08 35.0 0.0 1.8e-08 34.6 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO24023.1 - 7.4e-05 23.1 0.1 0.00011 22.6 0.1 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO24023.1 - 0.01 15.7 0.0 0.012 15.6 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain PH_12 PF16457.5 ETO24024.1 - 0.18 12.3 2.3 0.17 12.4 0.5 1.8 2 0 0 2 2 2 0 Pleckstrin homology domain DUF4600 PF15372.6 ETO24025.1 - 0.62 10.5 4.8 0.2 12.1 1.5 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4600) ADAM_CR_2 PF17771.1 ETO24025.1 - 2.1 8.9 5.0 9.1 6.9 0.6 2.2 2 0 0 2 2 2 0 ADAM cysteine-rich domain Trypsin PF00089.26 ETO24026.1 - 4.8e-09 36.3 0.1 2.9e-08 33.8 0.1 1.9 1 1 0 1 1 1 1 Trypsin Helicase_C_2 PF13307.6 ETO24027.1 - 8.4e-52 175.8 0.2 2.1e-51 174.5 0.2 1.7 1 0 0 1 1 1 1 Helicase C-terminal domain DEAD_2 PF06733.15 ETO24027.1 - 2e-35 122.0 7.8 2e-35 122.0 7.8 2.3 3 0 0 3 3 3 1 DEAD_2 Prefoldin_2 PF01920.20 ETO24028.1 - 9.8e-13 48.0 12.3 1.4e-12 47.5 12.3 1.2 1 0 0 1 1 1 1 Prefoldin subunit HTH_6 PF01418.17 ETO24028.1 - 0.055 13.5 1.4 0.16 12.0 0.1 2.2 2 0 0 2 2 2 0 Helix-turn-helix domain, rpiR family Spc24 PF08286.11 ETO24028.1 - 0.059 13.6 3.7 0.3 11.4 0.1 2.2 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 BRX_N PF13713.6 ETO24028.1 - 0.11 12.3 0.2 0.2 11.4 0.2 1.4 1 0 0 1 1 1 0 Transcription factor BRX N-terminal domain Lectin_N PF03954.14 ETO24028.1 - 0.19 11.5 1.9 0.28 10.9 0.5 1.9 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DivIC PF04977.15 ETO24028.1 - 0.32 10.8 10.1 0.86 9.4 2.5 2.6 1 1 2 3 3 3 0 Septum formation initiator DUF3636 PF12331.8 ETO24029.1 - 0.022 14.6 0.6 0.042 13.7 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) Tup_N PF08581.10 ETO24029.1 - 0.033 14.5 2.3 0.13 12.6 2.3 2.1 1 0 0 1 1 1 0 Tup N-terminal Toxin_17 PF08086.11 ETO24029.1 - 0.052 13.8 0.4 0.13 12.5 0.4 1.7 1 0 0 1 1 1 0 Ergtoxin family Caldesmon PF02029.15 ETO24029.1 - 0.085 11.6 29.5 0.12 11.1 29.5 1.2 1 0 0 1 1 1 0 Caldesmon Colicin_E5 PF12106.8 ETO24029.1 - 0.11 12.8 0.1 0.11 12.8 0.1 2.6 3 0 0 3 3 3 0 Colicin E5 ribonuclease domain DUF4446 PF14584.6 ETO24029.1 - 0.8 9.7 7.5 0.1 12.6 1.6 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) BUD22 PF09073.10 ETO24030.1 - 0.02 14.3 14.5 0.027 13.8 14.5 1.1 1 0 0 1 1 1 0 BUD22 CDC45 PF02724.14 ETO24030.1 - 0.026 12.8 6.7 0.026 12.8 6.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 ETO24030.1 - 0.045 12.4 7.4 0.052 12.2 7.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator DUF913 PF06025.12 ETO24030.1 - 0.13 11.2 4.1 0.067 12.2 2.2 1.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Tim54 PF11711.8 ETO24030.1 - 0.27 10.0 6.5 0.37 9.5 6.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Rhomboid_N PF12122.8 ETO24030.1 - 0.28 11.4 2.6 0.38 10.9 0.1 2.3 2 1 1 3 3 3 0 Cytoplasmic N-terminal domain of rhomboid serine protease Presenilin PF01080.17 ETO24030.1 - 0.97 8.1 6.2 1.3 7.7 6.2 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO24030.1 - 6.1 6.0 6.1 7.1 5.8 6.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DEAD PF00270.29 ETO24031.1 - 1.9e-21 76.6 0.2 3.9e-21 75.6 0.2 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO24031.1 - 2.5e-11 43.9 0.0 7.8e-11 42.3 0.0 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain CMS1 PF14617.6 ETO24031.1 - 0.0016 17.8 0.1 0.0034 16.8 0.1 1.5 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit XK-related PF09815.9 ETO24032.1 - 7.1e-07 28.6 5.5 7.1e-07 28.6 5.5 2.9 2 1 1 3 3 3 1 XK-related protein DUF5412 PF17428.2 ETO24032.1 - 0.043 13.7 1.3 1.1 9.1 0.2 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5412) FAM193_C PF15914.5 ETO24032.1 - 0.8 9.5 2.9 12 5.8 0.1 2.4 2 0 0 2 2 2 0 FAM193 family C-terminal Ac76 PF05814.11 ETO24033.1 - 0.37 10.8 5.4 0.26 11.3 0.4 3.0 3 0 0 3 3 3 0 Orf76 (Ac76) ATP-synt_8 PF00895.20 ETO24033.1 - 4.9 7.7 8.4 0.65 10.5 0.4 3.6 3 0 0 3 3 3 0 ATP synthase protein 8 PIG-P PF08510.12 ETO24034.1 - 0.16 11.9 0.3 1.3 8.9 0.1 2.0 1 1 1 2 2 2 0 PIG-P S-methyl_trans PF02574.16 ETO24035.1 - 6.4e-06 26.2 0.0 7.4e-06 26.0 0.0 1.0 1 0 0 1 1 1 1 Homocysteine S-methyltransferase ABC_tran PF00005.27 ETO24036.1 - 1e-08 35.8 0.0 1.7e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO24036.1 - 0.0018 18.1 0.0 0.004 17.0 0.0 1.7 1 1 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_23 PF13476.6 ETO24036.1 - 0.021 15.3 0.3 0.097 13.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain SMC_N PF02463.19 ETO24036.1 - 0.023 14.1 0.1 0.044 13.2 0.1 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain AAA_27 PF13514.6 ETO24036.1 - 0.034 13.7 0.0 0.085 12.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO24036.1 - 0.049 13.4 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ETO24036.1 - 0.095 12.2 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Rad17 PF03215.15 ETO24036.1 - 0.14 12.0 0.0 0.25 11.3 0.0 1.3 1 0 0 1 1 1 0 Rad17 P-loop domain Mg_chelatase PF01078.21 ETO24036.1 - 0.18 11.1 0.0 0.3 10.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI DUF4611 PF15387.6 ETO24036.1 - 0.6 10.4 4.7 1.6 9.0 4.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) WD40 PF00400.32 ETO24037.1 - 3.5e-17 62.4 16.6 1e-06 29.3 2.1 4.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24037.1 - 3.8e-09 36.7 0.0 0.0033 17.7 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24037.1 - 6.2e-09 35.1 3.5 0.016 13.9 0.2 4.2 2 1 2 4 4 4 3 Nucleoporin Nup120/160 Nup54 PF13874.6 ETO24038.1 - 4.6e-08 33.3 5.0 4.6e-08 33.3 5.0 1.8 1 1 1 2 2 2 1 Nucleoporin complex subunit 54 Nup54_C PF18437.1 ETO24038.1 - 0.0003 20.6 1.4 0.0003 20.6 1.4 2.4 3 0 0 3 3 2 1 Nup54 C-terminal interacting domain Cep57_MT_bd PF06657.13 ETO24038.1 - 0.0019 18.6 0.2 0.0019 18.6 0.2 2.9 3 0 0 3 3 2 1 Centrosome microtubule-binding domain of Cep57 DASH_Dad4 PF08650.10 ETO24038.1 - 0.0021 18.0 2.8 1.9 8.5 0.0 3.2 3 0 0 3 3 3 1 DASH complex subunit Dad4 DUF2935 PF11155.8 ETO24038.1 - 0.0022 18.3 0.0 0.14 12.5 0.0 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF2935) DUF3375 PF11855.8 ETO24038.1 - 0.0061 15.5 5.3 0.062 12.2 0.2 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3375) DUF4455 PF14643.6 ETO24038.1 - 0.0067 15.1 4.7 0.021 13.5 4.6 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4455) DUF1465 PF07323.12 ETO24038.1 - 0.0071 16.2 2.1 0.043 13.6 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1465) Herpes_TK PF00693.18 ETO24038.1 - 0.015 14.6 0.1 0.35 10.0 0.0 2.1 2 0 0 2 2 2 0 Thymidine kinase from herpesvirus Lebercilin PF15619.6 ETO24038.1 - 0.031 13.9 14.4 0.32 10.6 0.2 3.1 3 0 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Prominin PF05478.11 ETO24038.1 - 0.047 11.6 4.6 0.093 10.7 0.2 2.0 2 0 0 2 2 2 0 Prominin DUF2383 PF09537.10 ETO24038.1 - 0.095 13.0 4.8 1.2 9.5 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF2383) Synaptonemal_3 PF15191.6 ETO24038.1 - 0.1 12.4 2.5 5.1 6.9 0.3 2.7 2 1 0 2 2 2 0 Synaptonemal complex central element protein 3 Het-C PF07217.11 ETO24038.1 - 0.1 11.1 1.9 0.15 10.6 1.9 1.5 1 1 0 1 1 1 0 Heterokaryon incompatibility protein Het-C DUF412 PF04217.13 ETO24038.1 - 0.15 12.0 1.1 1.1 9.2 0.3 2.3 3 0 0 3 3 2 0 Protein of unknown function, DUF412 FliD_N PF02465.18 ETO24038.1 - 0.19 12.4 0.5 0.19 12.4 0.5 2.3 2 1 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus APG17 PF04108.12 ETO24038.1 - 0.22 10.6 6.6 0.45 9.6 6.0 1.7 1 1 1 2 2 2 0 Autophagy protein Apg17 OmpH PF03938.14 ETO24038.1 - 0.32 11.3 10.8 1.8 8.9 3.1 2.2 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) IL31 PF15209.6 ETO24038.1 - 0.32 10.8 2.9 0.31 10.8 0.2 2.3 2 1 0 2 2 2 0 Interleukin 31 KASH_CCD PF14662.6 ETO24038.1 - 0.32 10.8 10.3 0.91 9.3 1.9 2.2 2 0 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH 60KD_IMP PF02096.20 ETO24038.1 - 0.33 10.8 2.8 0.39 10.6 2.8 1.4 1 1 0 1 1 1 0 60Kd inner membrane protein DDHD PF02862.17 ETO24038.1 - 0.4 10.8 2.8 0.59 10.3 0.1 2.0 1 1 1 2 2 2 0 DDHD domain DUF2203 PF09969.9 ETO24038.1 - 0.41 11.4 5.5 1.5 9.6 0.4 2.2 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF1664 PF07889.12 ETO24038.1 - 0.69 10.0 9.1 8.5 6.4 1.9 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 ETO24038.1 - 1.2 8.3 6.9 2.4 7.3 0.2 2.0 2 0 0 2 2 2 0 TMPIT-like protein L27_1 PF09058.10 ETO24038.1 - 1.6 8.8 6.4 0.69 9.9 1.6 2.5 2 1 0 2 2 2 0 L27_1 bZIP_1 PF00170.21 ETO24038.1 - 1.6 8.8 18.2 8.8 6.5 7.0 3.2 3 0 0 3 3 3 0 bZIP transcription factor APG6_N PF17675.1 ETO24038.1 - 1.9 9.0 11.8 1.3 9.5 1.0 2.7 2 1 1 3 3 3 0 Apg6 coiled-coil region CorA PF01544.18 ETO24038.1 - 1.9 7.7 7.3 0.75 9.0 2.5 2.0 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein YabA PF06156.13 ETO24038.1 - 1.9 9.2 9.0 2.6 8.7 0.3 2.9 2 1 1 3 3 3 0 Initiation control protein YabA Baculo_PEP_C PF04513.12 ETO24038.1 - 2 8.5 5.7 12 5.9 0.1 2.5 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Dad2 PF08654.10 ETO24038.1 - 3 8.3 8.8 0.92 10.0 0.3 2.9 3 0 0 3 3 3 0 DASH complex subunit Dad2 Atg14 PF10186.9 ETO24038.1 - 5.1 6.1 8.2 1.3 8.0 2.4 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 UCH PF00443.29 ETO24040.1 - 3.8e-06 26.6 0.1 3.8e-06 26.6 0.1 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase FAM176 PF14851.6 ETO24040.1 - 0.0014 18.3 4.9 0.0017 18.0 4.9 1.3 1 0 0 1 1 1 1 FAM176 family DUF4471 PF14740.6 ETO24040.1 - 0.0023 17.2 4.0 0.0025 17.1 4.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4471) dsRBD2 PF17842.1 ETO24040.1 - 0.0027 17.9 4.3 0.0034 17.6 4.3 1.3 1 0 0 1 1 1 1 Double-stranded RNA binding domain 2 U79_P34 PF03064.16 ETO24040.1 - 0.0073 15.7 5.8 0.0096 15.3 5.8 1.2 1 0 0 1 1 1 1 HSV U79 / HCMV P34 Nop14 PF04147.12 ETO24040.1 - 0.011 14.0 14.2 0.013 13.8 14.2 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO24040.1 - 0.013 13.8 6.8 0.013 13.8 6.8 1.3 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO24040.1 - 0.027 13.8 11.6 0.029 13.7 11.6 1.0 1 0 0 1 1 1 0 BUD22 RR_TM4-6 PF06459.12 ETO24040.1 - 0.027 14.3 6.1 0.029 14.2 6.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RXT2_N PF08595.11 ETO24040.1 - 0.039 14.0 9.9 0.049 13.6 9.9 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal YTH PF04146.15 ETO24040.1 - 0.043 13.8 2.1 0.049 13.6 2.1 1.1 1 0 0 1 1 1 0 YT521-B-like domain CSRNP_N PF16019.5 ETO24040.1 - 0.047 13.6 3.0 0.057 13.3 3.0 1.1 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus UPF0524 PF15823.5 ETO24040.1 - 0.049 13.0 3.0 0.059 12.8 3.0 1.3 1 0 0 1 1 1 0 UPF0524 of C3orf70 NOA36 PF06524.12 ETO24040.1 - 0.05 12.9 13.6 0.07 12.4 13.6 1.3 1 0 0 1 1 1 0 NOA36 protein TRAP_alpha PF03896.16 ETO24040.1 - 0.053 12.7 5.0 0.064 12.4 5.0 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Afi1 PF07792.12 ETO24040.1 - 0.064 13.7 6.1 0.071 13.6 6.1 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2457 PF10446.9 ETO24040.1 - 0.07 12.3 13.4 0.079 12.1 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cytomega_UL84 PF06284.11 ETO24040.1 - 0.07 11.6 8.0 0.079 11.4 8.0 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein CobT PF06213.12 ETO24040.1 - 0.074 12.4 13.7 0.082 12.3 13.7 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FAM60A PF15396.6 ETO24040.1 - 0.082 12.9 5.0 0.088 12.8 5.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Nucleo_P87 PF07267.11 ETO24040.1 - 0.084 11.7 7.1 0.093 11.6 7.1 1.0 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 RNA_pol_3_Rpc31 PF11705.8 ETO24040.1 - 0.089 13.0 18.2 0.1 12.8 18.2 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CPSF100_C PF13299.6 ETO24040.1 - 0.089 13.0 4.5 0.11 12.6 4.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Myc_N PF01056.18 ETO24040.1 - 0.099 12.5 10.0 0.12 12.2 10.0 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Ribosomal_60s PF00428.19 ETO24040.1 - 0.11 13.1 10.5 0.17 12.5 10.5 1.4 1 0 0 1 1 1 0 60s Acidic ribosomal protein PI3K_1B_p101 PF10486.9 ETO24040.1 - 0.12 10.2 4.5 0.11 10.2 4.5 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit GNAT_acetyltr_2 PF13718.6 ETO24040.1 - 0.16 11.3 1.9 0.18 11.2 1.9 1.2 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CTU2 PF10288.9 ETO24040.1 - 0.18 12.0 4.4 0.23 11.7 4.4 1.2 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 NPR3 PF03666.13 ETO24040.1 - 0.2 10.4 5.9 0.21 10.4 5.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Pox_Ag35 PF03286.14 ETO24040.1 - 0.2 11.4 13.4 0.27 11.0 13.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO24040.1 - 0.22 9.6 17.2 0.25 9.4 17.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi RP-C_C PF11800.8 ETO24040.1 - 0.22 11.6 2.6 0.22 11.6 2.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4820 PF16091.5 ETO24040.1 - 0.22 10.9 6.4 0.25 10.7 6.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF913 PF06025.12 ETO24040.1 - 0.23 10.4 5.6 0.26 10.2 5.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4637 PF15470.6 ETO24040.1 - 0.23 11.2 9.5 0.28 10.9 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Presenilin PF01080.17 ETO24040.1 - 0.25 10.0 4.4 0.27 10.0 4.4 1.1 1 0 0 1 1 1 0 Presenilin HCO3_cotransp PF00955.21 ETO24040.1 - 0.3 9.9 0.2 0.36 9.6 0.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family RNA_pol_Rpc4 PF05132.14 ETO24040.1 - 0.32 11.4 5.8 0.39 11.1 5.8 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF4746 PF15928.5 ETO24040.1 - 0.51 9.7 11.9 0.61 9.5 11.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Connexin PF00029.19 ETO24040.1 - 0.53 10.0 2.8 0.6 9.8 2.8 1.1 1 0 0 1 1 1 0 Connexin CENP-B_dimeris PF09026.10 ETO24040.1 - 0.64 10.4 17.9 1 9.8 17.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Tim54 PF11711.8 ETO24040.1 - 0.87 8.3 10.4 1 8.1 10.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO24040.1 - 0.96 8.6 3.2 1 8.5 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PBP1_TM PF14812.6 ETO24040.1 - 1.2 9.6 12.2 1.8 9.0 12.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF789 PF05623.12 ETO24040.1 - 1.3 8.6 6.9 0.92 9.1 5.6 1.4 2 0 0 2 2 1 0 Protein of unknown function (DUF789) AIM3 PF17096.5 ETO24040.1 - 2 9.4 8.3 3.9 8.5 8.3 1.6 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 RPN2_C PF18004.1 ETO24040.1 - 2.1 8.3 12.5 2.6 8.0 12.5 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain PPL5 PF18168.1 ETO24040.1 - 2.2 7.5 7.4 2.5 7.3 7.4 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Sporozoite_P67 PF05642.11 ETO24040.1 - 2.7 6.0 8.8 3.1 5.8 8.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Astro_capsid_p PF12226.8 ETO24040.1 - 3 6.9 13.0 3.5 6.7 13.0 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein IBR PF01485.21 ETO24042.1 - 0.051 13.8 2.9 1.7 8.9 0.2 2.2 1 1 1 2 2 2 0 IBR domain, a half RING-finger domain zf-C2H2_aberr PF17017.5 ETO24042.1 - 0.089 12.9 0.1 0.11 12.6 0.1 1.2 1 0 0 1 1 1 0 Aberrant zinc-finger UCH PF00443.29 ETO24043.1 - 3.4e-05 23.5 0.2 4.1e-05 23.2 0.2 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Mer2 PF09074.10 ETO24043.1 - 0.012 15.4 0.9 0.012 15.4 0.9 1.6 2 0 0 2 2 2 0 Mer2 PNPase PF03726.14 ETO24043.1 - 0.15 12.6 1.0 0.52 10.8 0.3 2.2 2 0 0 2 2 2 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain UCH PF00443.29 ETO24044.1 - 3.6e-06 26.7 0.0 3.6e-06 26.7 0.0 2.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase BUD22 PF09073.10 ETO24044.1 - 0.0015 18.0 12.5 0.0018 17.7 12.5 1.2 1 0 0 1 1 1 1 BUD22 DUF913 PF06025.12 ETO24044.1 - 0.0017 17.4 2.7 0.0021 17.1 2.7 1.1 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Nop14 PF04147.12 ETO24044.1 - 0.002 16.5 15.3 0.0021 16.4 15.3 1.1 1 0 0 1 1 1 1 Nop14-like family DUF5523 PF17661.1 ETO24044.1 - 0.002 17.8 9.0 0.0025 17.5 9.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5523) Myc_N PF01056.18 ETO24044.1 - 0.0022 18.0 4.8 0.0023 17.9 4.8 1.2 1 0 0 1 1 1 1 Myc amino-terminal region CPSF100_C PF13299.6 ETO24044.1 - 0.0084 16.3 5.1 0.014 15.6 5.1 1.3 1 0 0 1 1 1 1 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 ETO24044.1 - 0.011 13.9 16.5 0.015 13.5 16.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO24044.1 - 0.026 12.8 10.3 0.03 12.7 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ETO24044.1 - 0.042 13.2 18.3 0.054 12.9 18.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 ETO24044.1 - 0.066 13.6 4.1 0.11 12.9 4.1 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nucleo_P87 PF07267.11 ETO24044.1 - 0.11 11.3 9.0 0.13 11.1 9.0 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 TRAP_alpha PF03896.16 ETO24044.1 - 0.13 11.5 6.8 0.18 11.0 6.8 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RXT2_N PF08595.11 ETO24044.1 - 0.15 12.1 12.5 0.3 11.1 12.5 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal Afi1 PF07792.12 ETO24044.1 - 0.2 12.1 10.2 0.34 11.4 10.2 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DDHD PF02862.17 ETO24044.1 - 0.28 11.3 2.9 0.29 11.3 2.9 1.2 1 0 0 1 1 1 0 DDHD domain NPR3 PF03666.13 ETO24044.1 - 0.29 9.9 8.1 0.32 9.7 8.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO24044.1 - 0.35 9.6 5.7 0.38 9.5 5.7 1.2 1 0 0 1 1 1 0 Presenilin DUF2457 PF10446.9 ETO24044.1 - 0.37 9.9 17.9 0.45 9.6 17.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF4820 PF16091.5 ETO24044.1 - 0.43 9.9 7.2 0.56 9.5 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Connexin PF00029.19 ETO24044.1 - 0.57 9.9 4.5 0.74 9.5 4.5 1.2 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ETO24044.1 - 1.1 8.4 4.8 1.2 8.2 4.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF789 PF05623.12 ETO24044.1 - 1.2 8.8 8.1 3.5 7.2 6.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF789) Tim54 PF11711.8 ETO24044.1 - 1.3 7.7 10.5 1.9 7.2 10.5 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF4746 PF15928.5 ETO24044.1 - 1.4 8.3 14.1 2 7.8 14.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) dsRBD2 PF17842.1 ETO24044.1 - 1.5 9.0 5.9 2.2 8.5 5.9 1.5 1 0 0 1 1 1 0 Double-stranded RNA binding domain 2 Cytomega_UL84 PF06284.11 ETO24044.1 - 3.4 6.0 13.7 3.2 6.1 12.4 1.5 1 1 1 2 2 2 0 Cytomegalovirus UL84 protein VIR_N PF15912.5 ETO24044.1 - 3.8 7.0 11.6 5.4 6.5 11.6 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal RRN3 PF05327.11 ETO24044.1 - 5.5 5.4 10.3 6.3 5.2 10.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Sporozoite_P67 PF05642.11 ETO24044.1 - 5.8 4.9 10.5 7.4 4.5 10.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen V_ATPase_I PF01496.19 ETO24044.1 - 8.7 4.1 10.3 12 3.7 10.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family FAM60A PF15396.6 ETO24044.1 - 9.6 6.1 12.4 5 7.1 10.6 1.4 1 1 0 1 1 1 0 Protein Family FAM60A ubiquitin PF00240.23 ETO24045.1 - 7.6e-06 25.6 0.2 2.7e-05 23.8 0.1 2.0 2 0 0 2 2 2 1 Ubiquitin family UPF0560 PF10577.9 ETO24045.1 - 0.0065 15.0 0.6 0.0088 14.6 0.6 1.1 1 0 0 1 1 1 1 Uncharacterised protein family UPF0560 FAM176 PF14851.6 ETO24045.1 - 0.72 9.5 3.7 1.2 8.7 3.7 1.3 1 0 0 1 1 1 0 FAM176 family DUF3915 PF13054.6 ETO24045.1 - 0.83 9.7 4.5 1.6 8.7 4.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 ETO24045.1 - 7.7 4.7 7.5 10 4.2 7.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family XPG_I PF00867.18 ETO24048.1 - 1.1e-22 80.2 0.1 2.7e-22 78.9 0.1 1.7 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ETO24048.1 - 1.5e-07 31.2 0.0 2.3e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 XPG domain containing XPG_N PF00752.17 ETO24048.1 - 0.00013 22.4 0.3 0.00036 21.0 0.3 1.7 1 0 0 1 1 1 1 XPG N-terminal domain 5_3_exonuc PF01367.20 ETO24048.1 - 0.0018 18.8 0.0 0.0049 17.4 0.0 1.7 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold ThiF PF00899.21 ETO24049.1 - 1.4e-11 44.2 0.6 3.2e-10 39.8 0.6 2.5 1 1 0 1 1 1 1 ThiF family Nop14 PF04147.12 ETO24052.1 - 0.0016 16.8 48.1 0.0027 16.0 48.1 1.4 1 0 0 1 1 1 1 Nop14-like family KCNQ2_u3 PF16642.5 ETO24052.1 - 1.9 9.5 7.8 32 5.6 7.9 3.2 1 1 0 1 1 1 0 Unstructured region on Potassium channel subunit alpha KvLQT2 TFIIA PF03153.13 ETO24052.1 - 2.1 8.2 61.2 0.06 13.3 39.2 2.1 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 ETO24053.1 - 3.4e-46 154.3 6.0 2.7e-11 43.8 0.0 5.8 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24053.1 - 7.3e-23 80.7 0.6 9.7e-05 22.6 0.2 6.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24053.1 - 3.9e-11 42.5 0.6 0.025 13.5 0.0 5.3 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO24053.1 - 9.9e-10 38.6 1.4 2.8e-05 24.1 0.1 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO24053.1 - 1.1e-07 31.5 1.6 0.01 15.2 0.2 3.2 1 1 4 5 5 5 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO24053.1 - 2.9e-05 22.8 0.5 0.074 11.6 0.2 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO24053.1 - 0.0011 18.8 0.8 2.1 8.4 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat TFIIIC_delta PF12657.7 ETO24053.1 - 0.022 14.7 1.7 0.063 13.2 0.8 2.1 1 1 1 2 2 2 0 Transcription factor IIIC subunit delta N-term Fibrinogen_aC PF12160.8 ETO24053.1 - 0.14 12.0 0.7 19 5.2 0.0 3.1 2 1 1 3 3 3 0 Fibrinogen alpha C domain Proteasome_A_N PF10584.9 ETO24053.1 - 0.16 11.7 1.4 14 5.5 0.1 3.7 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature AAA_18 PF13238.6 ETO24054.1 - 2.6e-05 24.8 0.0 5.2e-05 23.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO24054.1 - 9.1e-05 22.6 0.0 0.00015 22.0 0.0 1.4 1 1 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO24054.1 - 0.00013 22.5 0.0 0.00017 22.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter tRNA_lig_kinase PF08303.11 ETO24054.1 - 0.00016 21.8 0.1 0.00023 21.3 0.1 1.2 1 0 0 1 1 1 1 tRNA ligase kinase domain NB-ARC PF00931.22 ETO24054.1 - 0.0016 17.6 0.0 0.0033 16.7 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO24054.1 - 0.0017 18.7 0.0 0.0025 18.1 0.0 1.2 1 0 0 1 1 1 1 AAA domain PduV-EutP PF10662.9 ETO24054.1 - 0.0051 16.6 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 Ethanolamine utilisation - propanediol utilisation AAA_17 PF13207.6 ETO24054.1 - 0.0068 16.8 0.0 0.015 15.7 0.0 1.6 1 1 1 2 2 1 1 AAA domain T2SSE PF00437.20 ETO24054.1 - 0.0076 15.3 0.0 0.011 14.8 0.0 1.1 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_14 PF13173.6 ETO24054.1 - 0.0086 16.1 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ETO24054.1 - 0.0099 15.8 0.0 0.015 15.2 0.0 1.3 1 0 0 1 1 1 1 NACHT domain AAA_7 PF12775.7 ETO24054.1 - 0.012 15.1 0.4 0.023 14.2 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Parvo_NS1 PF01057.17 ETO24054.1 - 0.012 14.7 1.4 0.046 12.8 0.0 2.0 2 0 0 2 2 2 0 Parvovirus non-structural protein NS1 AAA_19 PF13245.6 ETO24054.1 - 0.016 15.5 0.0 0.022 15.1 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO24054.1 - 0.017 15.4 0.1 0.035 14.4 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO24054.1 - 0.017 14.8 0.0 0.027 14.2 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO24054.1 - 0.018 14.4 0.0 0.025 13.9 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family Septin PF00735.18 ETO24054.1 - 0.022 14.0 0.0 0.034 13.4 0.0 1.3 1 0 0 1 1 1 0 Septin dNK PF01712.19 ETO24054.1 - 0.025 14.5 0.0 0.04 13.8 0.0 1.4 1 0 0 1 1 1 0 Deoxynucleoside kinase ATP_bind_1 PF03029.17 ETO24054.1 - 0.028 14.2 0.0 0.041 13.7 0.0 1.2 1 0 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_29 PF13555.6 ETO24054.1 - 0.037 13.8 0.0 0.078 12.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRP54 PF00448.22 ETO24054.1 - 0.037 13.6 0.0 0.053 13.1 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain Roc PF08477.13 ETO24054.1 - 0.045 14.0 0.4 0.13 12.5 0.0 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase MobB PF03205.14 ETO24054.1 - 0.052 13.4 0.0 0.087 12.7 0.0 1.3 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA PF00004.29 ETO24054.1 - 0.053 14.0 0.0 0.067 13.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETO24054.1 - 0.063 13.0 0.0 0.1 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA domain TrwB_AAD_bind PF10412.9 ETO24054.1 - 0.069 12.1 0.0 0.099 11.5 0.0 1.1 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain TsaE PF02367.17 ETO24054.1 - 0.072 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Viral_helicase1 PF01443.18 ETO24054.1 - 0.073 12.8 0.0 0.17 11.6 0.0 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase PhoH PF02562.16 ETO24054.1 - 0.11 11.9 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_16 PF13191.6 ETO24054.1 - 0.11 12.8 0.0 0.16 12.3 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain cobW PF02492.19 ETO24054.1 - 0.12 12.0 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 ETO24054.1 - 0.12 11.6 0.0 0.2 10.9 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin GTP_EFTU PF00009.27 ETO24054.1 - 0.13 11.7 0.0 0.19 11.3 0.0 1.2 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF87 PF01935.17 ETO24054.1 - 0.14 12.2 0.0 0.25 11.4 0.0 1.5 2 0 0 2 2 1 0 Helicase HerA, central domain Mg_chelatase PF01078.21 ETO24054.1 - 0.25 10.7 0.0 0.35 10.2 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Myco_haema PF05692.12 ETO24055.1 - 0.039 12.9 0.8 0.046 12.7 0.8 1.0 1 0 0 1 1 1 0 Mycoplasma haemagglutinin Cdh1_DBD_1 PF18196.1 ETO24055.1 - 0.23 11.8 6.7 0.28 11.5 6.4 1.3 1 1 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 OSTbeta PF15048.6 ETO24055.1 - 0.23 11.6 3.1 0.33 11.1 3.1 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein MAS20 PF02064.15 ETO24055.1 - 0.38 10.8 5.7 0.52 10.4 5.7 1.2 1 0 0 1 1 1 0 MAS20 protein import receptor FH2 PF02181.23 ETO24056.1 - 8.2e-80 268.7 8.9 9e-80 268.6 8.9 1.0 1 0 0 1 1 1 1 Formin Homology 2 Domain Baculo_PEP_C PF04513.12 ETO24056.1 - 0.01 15.9 1.0 0.023 14.7 0.3 1.9 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus Phage_lysis PF03245.13 ETO24056.1 - 0.092 12.9 0.4 0.23 11.6 0.0 1.8 2 0 0 2 2 2 0 Bacteriophage Rz lysis protein PhageMin_Tail PF10145.9 ETO24056.1 - 0.11 12.4 0.0 0.21 11.4 0.0 1.4 1 0 0 1 1 1 0 Phage-related minor tail protein NPV_P10 PF05531.12 ETO24056.1 - 0.49 10.9 4.8 5.7 7.5 0.1 3.5 3 1 0 3 3 3 0 Nucleopolyhedrovirus P10 protein CHAT PF12770.7 ETO24057.1 - 0.023 14.1 0.4 2.6 7.4 0.1 2.4 1 1 1 2 2 2 0 CHAT domain Cwf_Cwc_15 PF04889.12 ETO24057.1 - 0.086 12.6 31.1 0.037 13.7 13.9 3.2 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein GCIP PF13324.6 ETO24057.1 - 0.1 12.2 11.2 0.025 14.2 5.1 2.3 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting CPSF100_C PF13299.6 ETO24057.1 - 0.32 11.1 3.9 22 5.2 0.0 2.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Sigma70_ner PF04546.13 ETO24057.1 - 1.5 8.7 15.7 0.028 14.3 5.0 2.6 3 0 0 3 3 3 0 Sigma-70, non-essential region RPN2_C PF18004.1 ETO24057.1 - 1.8 8.5 4.5 3.1 7.7 1.6 2.5 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain Nop14 PF04147.12 ETO24057.1 - 4.3 5.4 20.6 0.047 11.9 11.0 2.1 2 0 0 2 2 2 0 Nop14-like family DUF4718 PF15842.5 ETO24057.1 - 5.7 6.7 14.0 0.061 13.1 3.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4718) Proteasom_PSMB PF10508.9 ETO24058.1 - 0.00068 18.3 0.2 0.00077 18.1 0.2 1.1 1 0 0 1 1 1 1 Proteasome non-ATPase 26S subunit Adaptin_N PF01602.20 ETO24058.1 - 0.0014 17.3 1.1 0.0018 16.9 1.1 1.2 1 0 0 1 1 1 1 Adaptin N terminal region KicB PF03882.14 ETO24058.1 - 0.06 13.6 0.0 1.4 9.1 0.0 2.0 1 1 1 2 2 2 0 MukF winged-helix domain CD36 PF01130.21 ETO24060.1 - 1.2e-30 106.5 1.1 4e-30 104.7 1.1 1.7 1 1 0 1 1 1 1 CD36 family WD40 PF00400.32 ETO24061.1 - 5.4e-09 36.5 4.3 0.0044 17.8 0.0 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24061.1 - 0.00027 21.2 0.1 0.011 16.1 0.0 2.5 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24061.1 - 0.0097 14.9 0.0 0.038 12.9 0.0 1.7 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein IKI3 PF04762.12 ETO24061.1 - 0.011 13.8 0.1 0.013 13.6 0.1 1.3 1 0 0 1 1 1 0 IKI3 family PD40 PF07676.12 ETO24061.1 - 0.012 15.6 0.3 0.61 10.1 0.2 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO24061.1 - 0.32 10.7 1.0 3.9 7.2 0.0 3.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature ETRAMP PF09716.10 ETO24062.1 - 0.0098 15.9 0.2 0.0098 15.9 0.2 3.1 3 0 0 3 3 3 1 Malarial early transcribed membrane protein (ETRAMP) Cwf_Cwc_15 PF04889.12 ETO24062.1 - 0.014 15.1 2.4 0.014 15.1 2.4 2.0 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETO24062.1 - 3.1 6.0 7.5 0.81 7.9 1.3 2.1 2 0 0 2 2 2 0 CDC45-like protein ZapB PF06005.12 ETO24064.1 - 0.00038 20.9 0.6 0.069 13.6 0.0 2.5 2 0 0 2 2 2 1 Cell division protein ZapB Lipase_chap PF03280.14 ETO24064.1 - 0.022 14.7 0.3 1.1 9.1 0.1 2.1 2 0 0 2 2 2 0 Proteobacterial lipase chaperone protein DivIVA PF05103.13 ETO24064.1 - 0.03 14.4 3.3 0.89 9.6 0.5 2.3 2 0 0 2 2 2 0 DivIVA protein PRKG1_interact PF15898.5 ETO24064.1 - 0.16 12.9 0.1 0.16 12.9 0.1 2.8 2 1 0 2 2 2 0 cGMP-dependent protein kinase interacting domain FlaC_arch PF05377.11 ETO24064.1 - 0.73 10.3 5.3 14 6.2 0.3 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Histone_HNS PF00816.21 ETO24064.1 - 8.7 7.2 8.0 3.2 8.6 0.0 2.8 3 1 0 3 3 3 0 H-NS histone family HeH PF12949.7 ETO24065.1 - 0.076 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 HeH/LEM domain DUF2207 PF09972.9 ETO24066.1 - 0.00091 18.1 3.2 0.18 10.5 0.2 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) DUF4199 PF13858.6 ETO24066.1 - 0.0089 16.4 2.6 0.0089 16.4 2.6 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF4199) DUF2975 PF11188.8 ETO24066.1 - 0.028 14.3 6.2 0.062 13.2 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) Wzy_C PF04932.15 ETO24066.1 - 0.066 12.8 4.5 0.23 11.1 1.3 2.4 2 0 0 2 2 2 0 O-Antigen ligase CbiQ PF02361.16 ETO24066.1 - 0.15 11.6 5.2 0.04 13.5 1.0 1.9 2 0 0 2 2 2 0 Cobalt transport protein OSTbeta PF15048.6 ETO24066.1 - 0.62 10.2 6.6 0.33 11.1 2.0 2.5 2 1 1 3 3 3 0 Organic solute transporter subunit beta protein DUF4131 PF13567.6 ETO24066.1 - 0.88 9.2 9.2 0.11 12.1 1.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) MgtE PF01769.16 ETO24066.1 - 1.1 9.7 9.5 12 6.3 0.1 2.5 2 1 0 2 2 2 0 Divalent cation transporter Orf78 PF06024.12 ETO24066.1 - 5.7 7.3 8.3 1.9 8.9 0.3 3.0 2 1 0 2 2 2 0 Orf78 (ac78) Aldedh PF00171.22 ETO24069.1 - 1.5e-54 185.2 0.0 1.9e-54 184.9 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family CC2D2AN-C2 PF15625.6 ETO24070.1 - 5.6e-05 22.9 0.0 0.00011 22.0 0.0 1.4 1 0 0 1 1 1 1 CC2D2A N-terminal C2 domain GPCR_chapero_1 PF11904.8 ETO24072.1 - 4e-33 115.2 15.2 2.6e-21 76.4 7.9 2.5 2 1 0 2 2 2 2 GPCR-chaperone Pox_Ag35 PF03286.14 ETO24072.1 - 0.00017 21.4 4.3 0.00017 21.4 4.3 3.0 2 1 0 2 2 2 1 Pox virus Ag35 surface protein Ank_2 PF12796.7 ETO24073.1 - 2.5e-05 24.8 0.0 0.00015 22.2 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO24073.1 - 3.8e-05 24.1 0.1 0.0026 18.3 0.0 3.0 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO24073.1 - 0.0058 17.0 0.4 1.1 9.9 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO24073.1 - 0.01 16.1 0.1 0.95 9.9 0.0 3.1 2 1 0 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO24073.1 - 0.019 15.5 0.0 37 5.4 0.0 3.4 3 0 0 3 3 3 0 Ankyrin repeat DNA_pol_phi PF04931.13 ETO24073.1 - 0.054 11.6 2.7 0.077 11.1 2.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi CPSF100_C PF13299.6 ETO24073.1 - 0.48 10.6 3.4 0.77 9.9 2.4 1.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal BUD22 PF09073.10 ETO24073.1 - 0.9 8.8 9.2 0.11 11.8 4.9 1.5 2 0 0 2 2 2 0 BUD22 Cupin_8 PF13621.6 ETO24074.1 - 8.5e-29 101.0 0.2 8.5e-29 101.0 0.2 1.5 2 0 0 2 2 2 1 Cupin-like domain TLD PF07534.16 ETO24075.1 - 2.4e-28 99.1 0.3 4.8e-28 98.1 0.3 1.5 1 0 0 1 1 1 1 TLD WD40 PF00400.32 ETO24077.1 - 1.1e-05 26.0 6.6 1.5 9.8 0.4 4.9 5 0 0 5 5 5 2 WD domain, G-beta repeat TagF_N PF09867.9 ETO24077.1 - 0.041 13.9 0.0 0.094 12.7 0.0 1.5 1 0 0 1 1 1 0 TagF N-terminal domain, Type VI secretion system-associated DUF3537 PF12056.8 ETO24077.1 - 0.41 9.4 1.1 0.77 8.5 1.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3537) Pkinase_fungal PF17667.1 ETO24077.1 - 0.43 9.3 4.6 7.6 5.2 0.0 2.9 3 0 0 3 3 3 0 Fungal protein kinase Sec62 PF03839.16 ETO24077.1 - 0.46 10.0 2.3 0.8 9.2 2.3 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 NOA36 PF06524.12 ETO24077.1 - 0.81 8.9 9.2 1.9 7.7 9.2 1.5 1 0 0 1 1 1 0 NOA36 protein DUF3446 PF11928.8 ETO24077.1 - 2.1 8.7 7.1 3.3 8.1 5.6 2.1 2 0 0 2 2 2 0 Early growth response N-terminal domain adh_short PF00106.25 ETO24078.1 - 1.8e-40 138.5 0.4 7.6e-34 116.9 0.0 2.0 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO24078.1 - 2e-30 106.1 0.1 5.4e-28 98.1 0.0 2.0 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO24078.1 - 7.3e-13 48.8 0.3 1.5e-12 47.8 0.3 1.5 1 1 0 1 1 1 1 KR domain OSR1_C PF12202.8 ETO24078.1 - 0.038 14.2 2.2 0.062 13.5 2.2 1.4 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Epimerase PF01370.21 ETO24078.1 - 0.077 12.4 0.1 0.19 11.1 0.1 1.7 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETO24078.1 - 0.12 11.5 0.1 1.1 8.4 0.0 2.1 2 0 0 2 2 2 0 Male sterility protein zf-CCCH PF00642.24 ETO24079.1 - 0.00038 20.3 5.0 0.00038 20.3 5.0 2.2 3 0 0 3 3 3 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO24079.1 - 0.003 17.3 4.3 0.003 17.3 4.3 1.9 2 0 0 2 2 2 1 CCCH-type zinc finger CDC45 PF02724.14 ETO24079.1 - 2.4 6.4 23.7 2.6 6.2 23.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO24079.1 - 8 5.1 5.1 9.5 4.9 5.1 1.1 1 0 0 1 1 1 0 Presenilin Kelch_1 PF01344.25 ETO24080.1 - 1.4e-10 40.6 2.2 2.3e-06 27.1 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO24080.1 - 1.1e-07 31.9 1.9 0.032 14.5 0.2 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO24080.1 - 5.7e-06 26.2 0.9 0.0029 17.5 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO24080.1 - 0.00061 20.0 2.5 0.25 11.7 0.1 3.7 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO24080.1 - 0.00065 19.6 1.1 0.15 12.1 0.1 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO24080.1 - 0.079 13.0 3.7 0.08 13.0 0.1 2.9 4 0 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO24082.1 - 5.9e-41 137.7 15.1 7.2e-08 33.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24082.1 - 4.9e-16 58.8 0.4 0.00064 20.0 0.0 6.1 1 1 6 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO24082.1 - 2e-09 37.2 2.1 1.7e-05 24.3 0.6 3.5 2 1 2 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETO24082.1 - 1.8e-07 31.2 0.1 0.026 14.4 0.0 2.6 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO24082.1 - 3e-06 26.0 0.5 0.00051 18.7 0.0 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO24082.1 - 4.3e-05 23.3 0.2 1.4 8.9 0.0 4.2 4 1 1 5 5 5 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO24082.1 - 0.00017 20.7 0.8 2.7 6.9 0.1 4.7 2 1 1 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO24082.1 - 0.00067 18.4 0.7 4.1 5.9 0.0 3.8 2 1 1 4 4 4 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO24082.1 - 0.011 14.6 2.5 3.9 6.3 0.0 3.9 1 1 4 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Coatomer_WDAD PF04053.14 ETO24082.1 - 0.012 14.7 0.2 0.064 12.3 0.2 1.8 1 1 1 2 2 2 0 Coatomer WD associated region Cation_ATPase PF13246.6 ETO24082.1 - 0.015 15.4 0.1 2.4 8.3 0.0 2.5 1 1 1 2 2 2 0 Cation transport ATPase (P-type) DPPIV_N PF00930.21 ETO24082.1 - 0.027 13.3 0.3 0.72 8.5 0.0 2.8 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region SGL PF08450.12 ETO24082.1 - 0.061 12.9 0.0 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region Frtz PF11768.8 ETO24082.1 - 0.067 11.5 0.2 0.37 9.0 0.1 2.1 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Lactonase PF10282.9 ETO24082.1 - 0.15 11.3 0.1 1.5 8.0 0.2 2.3 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Proteasome_A_N PF10584.9 ETO24082.1 - 0.98 9.2 2.7 3.4 7.4 0.0 2.9 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature SAM_2 PF07647.17 ETO24083.1 - 2.5e-09 37.1 0.8 8.4e-09 35.4 0.2 2.3 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO24083.1 - 5.7e-07 29.9 0.8 2.7e-06 27.7 0.3 2.5 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) EF-hand_8 PF13833.6 ETO24083.1 - 1.3e-05 24.9 1.1 1.3e-05 24.9 1.1 2.4 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO24083.1 - 0.00012 21.8 0.4 0.0013 18.5 0.0 2.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 ETO24083.1 - 0.00027 20.3 0.6 0.00027 20.3 0.6 3.0 3 0 0 3 3 3 1 EF hand EF-hand_7 PF13499.6 ETO24083.1 - 0.00077 19.9 0.3 0.00077 19.9 0.3 2.3 2 1 0 2 2 2 1 EF-hand domain pair EutB PF06751.11 ETO24083.1 - 0.026 13.3 0.3 0.038 12.8 0.3 1.2 1 0 0 1 1 1 0 Ethanolamine ammonia lyase large subunit (EutB) EF-hand_5 PF13202.6 ETO24083.1 - 0.17 11.4 2.4 0.25 10.9 0.1 2.7 3 0 0 3 3 3 0 EF hand Upf2 PF04050.14 ETO24083.1 - 0.6 10.8 5.0 0.11 13.2 1.2 1.8 2 0 0 2 2 2 0 Up-frameshift suppressor 2 MIB_HERC2 PF06701.13 ETO24084.1 - 6.3e-07 29.6 5.6 8.3e-07 29.2 1.4 2.9 3 0 0 3 3 3 1 Mib_herc2 PTPRCAP PF15713.5 ETO24084.1 - 0.25 11.6 11.6 0.5 10.6 11.6 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Nucleos_tra2_N PF01773.20 ETO24085.1 - 0.18 12.4 1.6 0.32 11.6 0.1 2.2 3 0 0 3 3 3 0 Na+ dependent nucleoside transporter N-terminus OATP PF03137.20 ETO24086.1 - 0.00066 18.1 0.1 0.00072 18.0 0.1 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family 7tm_7 PF08395.12 ETO24086.1 - 0.017 14.4 2.7 0.022 14.0 2.7 1.3 1 1 0 1 1 1 0 7tm Chemosensory receptor DUF4083 PF13314.6 ETO24086.1 - 0.096 12.7 0.7 0.096 12.7 0.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) WBP-1 PF11669.8 ETO24086.1 - 0.11 13.1 0.5 4.6 7.9 0.0 2.2 1 1 1 2 2 2 0 WW domain-binding protein 1 DUF1077 PF06417.12 ETO24086.1 - 0.18 11.8 2.4 0.44 10.6 2.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1077) DUF4834 PF16118.5 ETO24086.1 - 0.72 10.8 4.9 2.4 9.2 4.7 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) SelK_SelG PF10961.8 ETO24086.1 - 1.5 9.4 3.7 6.9 7.4 3.7 2.1 2 1 0 2 2 2 0 Selenoprotein SelK_SelG HHV-5_US34A PF17087.5 ETO24086.1 - 8.4 6.6 9.8 3.5 7.9 2.9 2.5 2 0 0 2 2 2 0 Herpesvirus US34A protein family adh_short_C2 PF13561.6 ETO24087.1 - 0.00058 19.5 0.0 0.00078 19.1 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO24087.1 - 0.02 14.4 0.0 0.03 13.8 0.0 1.3 1 0 0 1 1 1 0 short chain dehydrogenase adh_short PF00106.25 ETO24088.1 - 4.9e-39 133.8 2.6 1.6e-21 76.7 0.2 2.0 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO24088.1 - 9.2e-24 84.3 0.5 2.1e-15 57.0 0.1 2.1 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO24088.1 - 7.1e-12 45.6 0.3 3.1e-06 27.2 0.1 2.1 1 1 1 2 2 2 2 KR domain GDP_Man_Dehyd PF16363.5 ETO24088.1 - 1.5e-05 24.5 0.2 0.0015 18.0 0.0 2.4 2 1 0 2 2 2 2 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETO24088.1 - 3.1e-05 23.6 0.1 0.00028 20.5 0.0 2.0 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_10 PF13460.6 ETO24088.1 - 0.0094 15.9 0.1 0.027 14.3 0.0 1.7 1 1 1 2 2 2 1 NAD(P)H-binding DUF3696 PF12476.8 ETO24088.1 - 0.016 15.6 0.8 0.077 13.4 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3696) PDGF_N PF04692.13 ETO24088.1 - 0.027 15.3 2.6 1.7 9.5 0.0 3.2 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region Eno-Rase_NADH_b PF12242.8 ETO24088.1 - 0.11 12.2 2.0 0.18 11.6 0.1 2.2 2 0 0 2 2 2 0 NAD(P)H binding domain of trans-2-enoyl-CoA reductase Flavodoxin_5 PF12724.7 ETO24088.1 - 0.66 10.2 3.9 0.44 10.8 1.5 1.9 2 1 0 2 2 2 0 Flavodoxin domain Myosin_head PF00063.21 ETO24089.1 - 2.3e-11 42.7 0.0 2.3e-11 42.7 0.0 2.8 3 0 0 3 3 3 1 Myosin head (motor domain) FliT PF05400.13 ETO24090.1 - 0.045 14.6 12.8 0.072 13.9 0.3 3.3 3 1 0 3 3 3 0 Flagellar protein FliT DUF3037 PF11236.8 ETO24090.1 - 0.08 13.4 3.3 6.6 7.2 0.5 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF3037) RPEL PF02755.15 ETO24090.1 - 0.24 11.2 6.8 4.5 7.1 0.1 3.3 3 0 0 3 3 3 0 RPEL repeat DUF1192 PF06698.11 ETO24090.1 - 0.67 10.0 5.3 2 8.5 0.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1192) Rx_N PF18052.1 ETO24090.1 - 1.2 9.4 12.7 11 6.4 0.9 3.6 3 0 0 3 3 3 0 Rx N-terminal domain Lzipper-MIP1 PF14389.6 ETO24090.1 - 1.8 8.9 13.0 1.7 9.0 3.5 3.4 2 1 2 4 4 4 0 Leucine-zipper of ternary complex factor MIP1 RRM_1 PF00076.22 ETO24091.1 - 1.7e-09 37.3 0.1 4.6e-09 36.0 0.1 1.8 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4549 PF15082.6 ETO24091.1 - 0.045 13.5 2.3 0.091 12.6 2.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4549) CDC45 PF02724.14 ETO24091.1 - 0.85 7.8 9.5 0.93 7.7 9.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO24091.1 - 1.2 8.3 4.9 1.6 7.9 4.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ndc1_Nup PF09531.10 ETO24091.1 - 2 7.0 9.8 2.1 6.9 9.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.14 ETO24091.1 - 2.2 8.2 12.3 3 7.8 12.3 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TMEM214 PF10151.9 ETO24091.1 - 5 5.5 13.3 7.9 4.8 13.3 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator V_ATPase_I PF01496.19 ETO24091.1 - 7.7 4.3 9.9 9.5 4.0 9.9 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ETO24091.1 - 7.8 5.1 13.7 9.5 4.9 13.7 1.3 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO24091.1 - 9.9 4.6 17.0 12 4.3 17.0 1.1 1 0 0 1 1 1 0 Macoilin family FBPase PF00316.20 ETO24092.1 - 1.2e-38 132.5 0.0 6.2e-38 130.2 0.0 1.8 1 1 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Inositol_P PF00459.25 ETO24092.1 - 0.034 13.7 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 Inositol monophosphatase family Sec8_exocyst PF04048.14 ETO24093.1 - 0.17 11.8 1.3 1.3 8.9 0.3 2.7 3 0 0 3 3 3 0 Sec8 exocyst complex component specific domain Vfa1 PF08432.10 ETO24094.1 - 0.048 14.0 8.4 0.091 13.1 8.4 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 FAD-SLDH PF12318.8 ETO24094.1 - 0.068 13.2 0.6 0.1 12.7 0.6 1.2 1 0 0 1 1 1 0 Membrane bound FAD containing D-sorbitol dehydrogenase DUF2951 PF11166.8 ETO24094.1 - 0.25 11.6 4.8 0.49 10.7 4.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) DUF2208 PF09973.9 ETO24094.1 - 1.1 8.9 3.8 1.1 8.9 0.8 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2208) ABC2_membrane_3 PF12698.7 ETO24094.1 - 2.2 7.3 6.5 3.5 6.6 6.5 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein PRCC PF10253.9 ETO24095.1 - 0.18 12.6 12.6 0.23 12.2 12.6 1.2 1 0 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting CDC45 PF02724.14 ETO24095.1 - 1.7 6.8 6.4 2.1 6.5 6.4 1.0 1 0 0 1 1 1 0 CDC45-like protein CPP1-like PF11833.8 ETO24096.1 - 0.059 13.0 0.2 0.18 11.5 0.2 1.8 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like TFIIE_alpha PF02002.17 ETO24097.1 - 0.092 12.6 0.3 0.24 11.3 0.3 1.6 1 0 0 1 1 1 0 TFIIE alpha subunit LRR_6 PF13516.6 ETO24097.1 - 0.3 11.2 8.7 0.69 10.1 0.1 4.8 5 1 1 6 6 6 0 Leucine Rich repeat Kelch_1 PF01344.25 ETO24099.1 - 1.9e-07 30.6 2.7 0.0089 15.6 0.2 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO24099.1 - 2.4e-07 30.6 0.4 0.089 12.8 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO24099.1 - 4.1e-05 23.7 1.0 0.022 15.1 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO24099.1 - 5.8e-05 23.2 6.3 0.99 9.8 0.1 4.5 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO24099.1 - 0.00019 21.3 6.0 0.16 12.0 0.3 4.5 4 1 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO24099.1 - 0.027 14.5 3.6 0.24 11.4 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF295 PF03478.18 ETO24099.1 - 0.1 12.2 0.3 14 5.4 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF295) NinG PF05766.12 ETO24099.1 - 0.95 9.4 7.1 0.15 12.0 0.6 2.4 2 1 0 2 2 2 0 Bacteriophage Lambda NinG protein RHH_3 PF12651.7 ETO24101.1 - 0.046 13.7 0.0 1.9 8.5 0.0 2.2 2 0 0 2 2 2 0 Ribbon-helix-helix domain DUF1086 PF06461.11 ETO24101.1 - 0.072 12.9 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF1086) Thymopoietin PF08198.11 ETO24101.1 - 0.27 10.8 1.4 1.1 9.0 0.6 2.4 2 1 0 2 2 2 0 Thymopoietin protein WD40 PF00400.32 ETO24102.1 - 1.8e-07 31.7 5.3 0.00055 20.7 1.5 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat NIF PF03031.18 ETO24102.1 - 0.039 13.7 0.1 0.075 12.8 0.1 1.4 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase Rsm1 PF08600.10 ETO24102.1 - 0.099 12.8 0.1 0.2 11.8 0.1 1.5 1 0 0 1 1 1 0 Rsm1-like Connexin PF00029.19 ETO24103.1 - 0.0005 19.9 2.5 0.2 11.4 0.0 2.1 2 0 0 2 2 2 2 Connexin DUF3405 PF11885.8 ETO24103.1 - 0.0032 16.2 1.5 0.0048 15.6 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) EST1 PF10374.9 ETO24103.1 - 0.004 17.8 1.7 0.11 13.2 0.3 2.2 2 0 0 2 2 2 1 Telomerase activating protein Est1 Tim54 PF11711.8 ETO24103.1 - 0.0057 15.5 3.1 0.54 9.0 0.2 2.1 2 0 0 2 2 2 2 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 ETO24103.1 - 0.0061 16.7 5.6 0.31 11.2 0.3 2.1 2 0 0 2 2 2 2 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 ETO24103.1 - 0.0069 16.8 4.2 0.84 10.1 0.0 2.1 2 0 0 2 2 2 1 RNA polymerase III RPC4 POX PF07526.11 ETO24103.1 - 0.0071 16.9 2.9 0.46 11.1 0.1 2.1 2 0 0 2 2 2 1 Associated with HOX Folate_carrier PF01770.18 ETO24103.1 - 0.0093 14.7 2.7 0.29 9.8 0.3 2.0 2 0 0 2 2 2 1 Reduced folate carrier RasGEF_N PF00618.20 ETO24103.1 - 0.012 15.9 3.3 0.043 14.1 0.7 2.1 2 0 0 2 2 2 0 RasGEF N-terminal motif Mlh1_C PF16413.5 ETO24103.1 - 0.015 14.7 2.1 2 7.7 0.1 2.1 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus Vfa1 PF08432.10 ETO24103.1 - 0.045 14.1 17.5 0.15 12.4 3.2 2.1 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 KIND PF16474.5 ETO24103.1 - 0.046 13.6 0.5 0.046 13.6 0.5 1.7 2 0 0 2 2 2 0 Kinase non-catalytic C-lobe domain SHR3_chaperone PF08229.11 ETO24103.1 - 0.082 11.9 0.2 0.082 11.9 0.2 2.3 2 1 0 2 2 1 0 ER membrane protein SH3 DUF913 PF06025.12 ETO24103.1 - 0.083 11.8 2.2 0.9 8.5 0.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Afi1 PF07792.12 ETO24103.1 - 0.11 13.0 11.2 0.83 10.1 1.9 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CPP1-like PF11833.8 ETO24103.1 - 0.12 12.0 1.0 1.5 8.4 0.0 2.1 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like Presenilin PF01080.17 ETO24103.1 - 0.22 10.3 4.8 0.41 9.4 4.8 1.3 1 1 0 1 1 1 0 Presenilin NinG PF05766.12 ETO24103.1 - 0.23 11.4 12.4 1.9 8.4 1.8 2.1 2 0 0 2 2 2 0 Bacteriophage Lambda NinG protein Gti1_Pac2 PF09729.9 ETO24103.1 - 0.26 11.4 8.9 0.99 9.5 2.1 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family RPA43_OB PF17875.1 ETO24103.1 - 0.26 11.9 9.1 2.7 8.6 1.1 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I TRAP_alpha PF03896.16 ETO24103.1 - 0.27 10.4 5.6 1.9 7.6 1.0 2.1 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Ureide_permease PF07168.11 ETO24103.1 - 0.3 9.8 1.3 7.7 5.2 0.1 2.1 2 0 0 2 2 2 0 Ureide permease DUF4834 PF16118.5 ETO24103.1 - 0.34 11.9 5.0 4.7 8.2 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) AIF_C PF14721.6 ETO24103.1 - 0.44 10.9 8.0 2.8 8.3 1.2 2.1 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term SpoIIP PF07454.11 ETO24103.1 - 0.73 9.2 12.8 2.2 7.7 3.3 2.1 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) RR_TM4-6 PF06459.12 ETO24103.1 - 0.74 9.6 12.3 1.8 8.3 3.2 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 HDA2-3 PF11496.8 ETO24103.1 - 0.75 8.9 12.8 0.56 9.3 1.1 2.1 2 0 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 RNA_pol_Rpb4 PF03874.16 ETO24103.1 - 0.85 10.0 9.3 0.27 11.6 0.4 2.2 2 0 0 2 2 2 0 RNA polymerase Rpb4 FAM176 PF14851.6 ETO24103.1 - 0.98 9.1 13.9 0.77 9.4 4.3 2.1 2 0 0 2 2 2 0 FAM176 family CLN3 PF02487.17 ETO24103.1 - 1.1 8.2 9.8 0.1 11.6 0.5 2.0 1 1 1 2 2 2 0 CLN3 protein CDC45 PF02724.14 ETO24103.1 - 1.3 7.3 13.1 0.62 8.3 0.8 2.0 2 0 0 2 2 2 0 CDC45-like protein Rgp1 PF08737.10 ETO24103.1 - 1.3 8.1 8.4 0.59 9.3 0.9 2.0 2 0 0 2 2 2 0 Rgp1 Phage_Gp23 PF10669.9 ETO24103.1 - 1.5 9.2 11.3 0.17 12.2 1.5 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Orf78 PF06024.12 ETO24103.1 - 1.6 9.1 5.4 40 4.6 2.9 2.5 2 0 0 2 2 2 0 Orf78 (ac78) Coilin_N PF15862.5 ETO24103.1 - 1.7 8.4 17.6 1.4 8.7 6.0 2.3 2 0 0 2 2 2 0 Coilin N-terminus EIIBC-GUT_N PF03612.14 ETO24103.1 - 3 7.5 8.8 6.2 6.5 1.0 2.1 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DUF1840 PF08895.11 ETO24103.1 - 3 8.2 9.9 8.1 6.8 2.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) DUF1764 PF08576.10 ETO24103.1 - 3.1 8.7 19.5 0.27 12.1 4.3 2.2 2 0 0 2 2 2 0 Eukaryotic protein of unknown function (DUF1764) GEN1_C PF18380.1 ETO24103.1 - 3.6 8.5 11.4 4.2 8.3 0.6 2.2 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Sec62 PF03839.16 ETO24103.1 - 3.9 6.9 14.1 5.5 6.4 3.2 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 Afaf PF15339.6 ETO24103.1 - 4.9 6.8 9.9 0.6 9.8 2.1 2.1 2 0 0 2 2 2 0 Acrosome formation-associated factor DUF3464 PF11947.8 ETO24103.1 - 5.5 6.7 11.9 3.5 7.4 0.7 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Zip PF02535.22 ETO24103.1 - 5.9 6.0 8.5 6.9 5.8 0.5 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter PBP1_TM PF14812.6 ETO24103.1 - 6 7.3 13.7 2 8.9 1.7 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2956 PF11169.8 ETO24103.1 - 6.1 7.1 19.9 2.2 8.5 5.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) CobT PF06213.12 ETO24103.1 - 6.5 6.1 12.3 1.7 8.0 3.5 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT RPN2_C PF18004.1 ETO24103.1 - 7.6 6.4 19.6 1.9 8.4 3.1 2.1 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain S-antigen PF05756.11 ETO24103.1 - 9 6.7 9.5 0.65 10.4 0.5 2.4 2 0 0 2 2 2 0 S-antigen protein fn3 PF00041.21 ETO24104.1 - 0.0077 16.5 0.2 0.063 13.6 0.1 2.7 3 1 0 3 3 3 1 Fibronectin type III domain DUF1295 PF06966.12 ETO24107.1 - 4.5e-16 59.1 10.8 6.7e-16 58.5 10.8 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) Holin_9 PF16936.5 ETO24107.1 - 0.26 11.5 3.9 0.78 9.9 3.9 1.7 1 0 0 1 1 1 0 Putative holin Amidohydro_1 PF01979.20 ETO24108.1 - 3.3e-23 82.6 0.3 4e-23 82.3 0.3 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ETO24108.1 - 0.00045 19.8 0.1 0.00065 19.3 0.1 1.6 1 1 0 1 1 1 1 Amidohydrolase family DDHD PF02862.17 ETO24109.1 - 0.29 11.3 15.6 0.4 10.8 15.6 1.3 1 0 0 1 1 1 0 DDHD domain SET PF00856.28 ETO24109.1 - 0.99 9.8 6.5 1.4 9.3 6.5 1.4 1 0 0 1 1 1 0 SET domain Raftlin PF15250.6 ETO24109.1 - 3.9 6.1 18.8 5 5.8 18.8 1.2 1 0 0 1 1 1 0 Raftlin Peptidase_S64 PF08192.11 ETO24109.1 - 7.4 4.9 18.5 8.6 4.7 18.5 1.1 1 0 0 1 1 1 0 Peptidase family S64 LicD PF04991.13 ETO24109.1 - 8.6 6.4 14.2 13 5.8 14.2 1.3 1 0 0 1 1 1 0 LicD family Zip PF02535.22 ETO24109.1 - 9.8 5.3 13.2 11 5.1 13.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Ank_2 PF12796.7 ETO24111.1 - 9e-08 32.6 0.3 0.0094 16.5 0.0 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO24111.1 - 1.1e-07 32.3 0.1 0.0039 17.7 0.0 3.7 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO24111.1 - 3.7e-06 26.9 0.1 0.041 14.4 0.0 3.3 3 0 0 3 3 3 2 Ankyrin repeat Ank_5 PF13857.6 ETO24111.1 - 1.2e-05 25.5 0.0 0.17 12.2 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO24111.1 - 0.00099 19.5 0.1 1.9 9.1 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat DUF4878 PF12870.7 ETO24112.1 - 0.021 15.1 1.3 0.021 15.1 1.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4878) YL1 PF05764.13 ETO24113.1 - 0.028 14.5 15.1 0.21 11.7 3.8 2.2 1 1 1 2 2 2 0 YL1 nuclear protein RNA_pol_Rbc25 PF08292.12 ETO24113.1 - 0.25 11.6 5.1 3.1 8.1 1.5 2.9 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 DUF4611 PF15387.6 ETO24113.1 - 1.4 9.2 14.7 0.31 11.3 2.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) PBP1_TM PF14812.6 ETO24113.1 - 5.1 7.5 16.5 7.9 6.9 6.4 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SPA PF08616.10 ETO24115.1 - 5.5e-11 42.4 0.5 1.2e-10 41.4 0.2 1.7 2 0 0 2 2 2 1 Stabilization of polarity axis Avl9 PF09794.9 ETO24115.1 - 0.0055 15.4 0.0 0.011 14.5 0.0 1.3 1 1 0 1 1 1 1 Transport protein Avl9 DUF2347 PF09804.9 ETO24115.1 - 0.029 14.0 0.0 0.058 13.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) DUF1618 PF07762.14 ETO24116.1 - 0.062 13.9 0.3 0.08 13.6 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1618) bZIP_1 PF00170.21 ETO24117.1 - 0.0017 18.4 5.8 0.32 11.1 0.2 2.3 2 1 0 2 2 2 2 bZIP transcription factor JAKMIP_CC3 PF16034.5 ETO24117.1 - 0.0044 17.0 8.8 0.15 12.0 0.4 2.0 1 1 1 2 2 2 2 JAKMIP CC3 domain KASH_CCD PF14662.6 ETO24117.1 - 0.0055 16.6 10.7 0.016 15.0 10.7 1.6 1 1 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH CENP-F_leu_zip PF10473.9 ETO24117.1 - 0.012 15.6 9.6 0.021 14.8 9.6 1.4 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ZapB PF06005.12 ETO24117.1 - 0.019 15.4 8.3 2.1 8.8 8.3 2.1 1 1 0 1 1 1 0 Cell division protein ZapB Atx10homo_assoc PF09759.9 ETO24117.1 - 0.02 14.9 1.9 0.042 13.9 0.1 2.0 1 1 0 2 2 2 0 Spinocerebellar ataxia type 10 protein domain CLZ PF16526.5 ETO24117.1 - 0.021 15.2 0.7 0.021 15.2 0.7 2.1 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels YabA PF06156.13 ETO24117.1 - 0.059 14.0 7.9 0.68 10.6 6.8 2.0 1 1 1 2 2 2 0 Initiation control protein YabA Fungal_TACC PF12709.7 ETO24117.1 - 0.084 13.3 6.2 0.19 12.2 0.3 2.2 1 1 1 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins HAUS-augmin3 PF14932.6 ETO24117.1 - 0.1 12.2 8.8 0.1 12.2 8.8 1.0 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 3 bZIP_2 PF07716.15 ETO24117.1 - 0.51 10.5 9.5 3.7 7.7 4.1 2.4 2 1 0 2 2 2 0 Basic region leucine zipper Atg14 PF10186.9 ETO24117.1 - 0.61 9.1 7.6 0.74 8.8 7.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MJ1316 PF04457.12 ETO24118.1 - 3.1e-13 50.2 0.5 1.5e-12 48.0 0.2 2.3 2 0 0 2 2 2 1 MJ1316 RNA cyclic group end recognition domain Exo_endo_phos PF03372.23 ETO24118.1 - 4.9e-11 42.6 0.0 9.1e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ETO24118.1 - 0.0086 15.9 2.2 0.55 10.1 0.1 3.4 3 0 0 3 3 3 1 Endonuclease-reverse transcriptase Polbeta PF18765.1 ETO24118.1 - 0.027 14.5 0.0 0.15 12.2 0.0 2.3 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase NTP_transf_2 PF01909.23 ETO24118.1 - 0.033 14.5 0.0 0.13 12.6 0.0 2.0 1 0 0 1 1 1 0 Nucleotidyltransferase domain DUF4834 PF16118.5 ETO24118.1 - 2 9.4 11.1 0.34 11.9 0.9 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Pet127 PF08634.10 ETO24118.1 - 3.9 6.8 6.4 2.2 7.7 0.5 2.9 3 0 0 3 3 3 0 Mitochondrial protein Pet127 DTHCT PF08070.11 ETO24119.1 - 0.0029 18.3 23.5 0.0074 17.0 23.5 1.6 1 1 0 1 1 1 1 DTHCT (NUC029) region Dehydrin PF00257.19 ETO24119.1 - 0.029 14.9 9.7 0.034 14.7 9.7 1.2 1 0 0 1 1 1 0 Dehydrin DUF4196 PF13846.6 ETO24119.1 - 0.074 13.3 11.6 0.12 12.6 11.6 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4196) TFIIF_alpha PF05793.12 ETO24119.1 - 0.52 8.8 18.1 0.66 8.5 18.1 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FRG2 PF15315.6 ETO24119.1 - 2.8 8.1 10.0 3.4 7.8 10.0 1.2 1 0 0 1 1 1 0 Facioscapulohumeral muscular dystrophy candidate 2 CDC45 PF02724.14 ETO24119.1 - 5.3 5.2 10.9 5.4 5.2 10.9 1.1 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ETO24119.1 - 6.9 5.3 11.3 7.8 5.2 11.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CE2_N PF17996.1 ETO24121.1 - 0.88 9.6 0.0 0.88 9.6 0.0 2.5 3 0 0 3 3 3 0 Carbohydrate esterase 2 N-terminal RabGAP-TBC PF00566.18 ETO24122.1 - 3.6e-34 118.3 0.6 3.6e-34 118.3 0.6 3.5 4 0 0 4 4 4 2 Rab-GTPase-TBC domain DUF3644 PF12358.8 ETO24122.1 - 0.052 14.0 1.5 0.13 12.7 1.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3644) SYCP2_ARLD PF18581.1 ETO24123.1 - 0.022 14.8 0.1 0.06 13.3 0.1 1.8 2 0 0 2 2 2 0 Synaptonemal complex 2 armadillo-repeat-like domain Pet100 PF09803.9 ETO24123.1 - 0.1 13.1 0.0 0.24 11.9 0.0 1.6 1 0 0 1 1 1 0 Pet100 Secretin_N_2 PF07655.13 ETO24124.1 - 1.4 9.5 16.5 3.2 8.4 16.5 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain Tli4_N PF18443.1 ETO24125.1 - 0.17 12.3 3.1 1.5 9.2 2.2 2.1 2 0 0 2 2 2 0 Tle cognate immunity protein 4 N-terminal domain zf-UBP_var PF17807.1 ETO24126.1 - 3.9e-20 71.4 0.1 1e-19 70.0 0.0 1.8 2 0 0 2 2 2 1 Variant UBP zinc finger zf-UBP PF02148.19 ETO24126.1 - 5.8e-14 52.2 0.0 1.3e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 Zn-finger in ubiquitin-hydrolases and other protein T4_baseplate PF12322.8 ETO24126.1 - 0.062 12.8 0.0 0.089 12.3 0.0 1.2 1 0 0 1 1 1 0 T4 bacteriophage base plate protein UCH PF00443.29 ETO24127.1 - 1.8e-29 103.0 0.5 2.5e-29 102.6 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 ETO24127.1 - 4.3e-12 45.7 0.2 5.6e-06 26.1 0.0 2.6 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 ETO24127.1 - 1.2e-08 35.0 12.2 6.3e-07 29.3 5.7 2.9 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase HOIP-UBA PF16678.5 ETO24127.1 - 0.0036 17.3 0.1 0.014 15.4 0.0 1.9 2 0 0 2 2 2 1 HOIP UBA domain pair UBA_2 PF08587.11 ETO24127.1 - 0.095 12.8 0.3 0.49 10.5 0.0 2.4 3 0 0 3 3 3 0 Ubiquitin associated domain (UBA) DUF3612 PF12268.8 ETO24127.1 - 0.14 12.3 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3612) PDEase_I PF00233.19 ETO24128.1 - 6.7e-77 258.4 9.3 1.4e-42 146.1 6.2 2.2 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase GATase PF00117.28 ETO24129.1 - 0.0023 17.7 0.0 0.0047 16.7 0.0 1.5 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO24129.1 - 0.024 14.4 0.0 0.046 13.5 0.0 1.5 1 0 0 1 1 1 0 Peptidase C26 DUF4662 PF15578.6 ETO24129.1 - 4.6 7.0 12.5 7.9 6.2 12.5 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4662) Dsh_C PF12316.8 ETO24129.1 - 5.6 7.3 7.6 8.4 6.7 7.6 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal WD40 PF00400.32 ETO24130.1 - 8.3e-37 124.6 32.8 1.4e-07 32.1 1.4 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24130.1 - 1.3e-09 38.2 2.1 0.0096 16.2 0.0 5.0 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24130.1 - 1.9e-09 36.7 6.8 0.00051 18.8 1.0 4.1 2 2 2 4 4 4 4 Nucleoporin Nup120/160 FAM76 PF16046.5 ETO24130.1 - 0.07 12.5 3.1 0.14 11.5 3.1 1.5 1 0 0 1 1 1 0 FAM76 protein zf-TRAF PF02176.18 ETO24131.1 - 6.5e-05 23.5 0.7 6.5e-05 23.5 0.7 2.5 2 1 0 2 2 2 1 TRAF-type zinc finger DUF2681 PF10883.8 ETO24132.1 - 0.036 14.5 2.9 0.083 13.3 0.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) DUF2085 PF09858.9 ETO24134.1 - 6.9 7.2 9.3 0.78 10.2 3.2 2.6 2 1 0 2 2 2 0 Predicted membrane protein (DUF2085) bVLRF1 PF18826.1 ETO24135.1 - 2.4e-32 111.8 0.1 9.4e-28 97.0 0.0 2.3 1 1 1 2 2 2 2 bacteroidetes VLRF1 release factor zf-NPL4 PF05020.15 ETO24135.1 - 0.01 16.0 1.5 0.081 13.1 0.5 2.3 1 1 1 2 2 2 0 NPL4 family, putative zinc binding region CENP-B_dimeris PF09026.10 ETO24135.1 - 0.098 13.1 7.2 0.2 12.1 7.2 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BACK PF07707.15 ETO24136.1 - 3.7e-09 36.6 1.1 8.7e-09 35.4 1.1 1.6 1 0 0 1 1 1 1 BTB And C-terminal Kelch BTB PF00651.31 ETO24136.1 - 3.4e-05 24.0 0.0 8.6e-05 22.7 0.0 1.7 1 0 0 1 1 1 1 BTB/POZ domain SAM_2 PF07647.17 ETO24137.1 - 0.00023 21.2 0.1 0.00071 19.6 0.1 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO24137.1 - 0.01 16.3 0.0 0.035 14.5 0.0 2.0 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO24137.1 - 0.011 15.7 0.6 0.041 13.8 0.2 2.2 2 0 0 2 2 2 0 Sterile alpha motif (SAM)/Pointed domain DUF1719 PF08224.11 ETO24137.1 - 0.036 13.2 1.1 1.1 8.3 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF1719) Reovirus_M2 PF05993.12 ETO24138.1 - 0.08 11.0 0.0 0.093 10.8 0.0 1.0 1 0 0 1 1 1 0 Reovirus major virion structural protein Mu-1/Mu-1C (M2) ArgoL2 PF16488.5 ETO24138.1 - 0.11 12.9 0.0 0.19 12.1 0.0 1.4 1 0 0 1 1 1 0 Argonaute linker 2 domain WD40 PF00400.32 ETO24141.1 - 0.004 18.0 0.2 0.59 11.1 0.1 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat DUF2986 PF11661.8 ETO24141.1 - 2.4 8.7 7.1 3.2 8.4 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2986) tRNA-synt_1e PF01406.19 ETO24142.1 - 0.025 13.9 0.0 0.035 13.4 0.0 1.1 1 0 0 1 1 1 0 tRNA synthetases class I (C) catalytic domain DUF573 PF04504.14 ETO24143.1 - 0.18 12.5 0.7 3 8.6 0.1 2.6 2 1 0 2 2 2 0 Protein of unknown function, DUF573 TetR_C_19 PF17924.1 ETO24143.1 - 0.18 12.4 0.1 0.18 12.4 0.1 2.1 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain Ncstrn_small PF18266.1 ETO24144.1 - 4.5e-16 59.3 0.2 6.3e-16 58.9 0.2 1.1 1 0 0 1 1 1 1 Nicastrin small lobe EF-hand_1 PF00036.32 ETO24145.1 - 0.036 13.6 0.4 1.8 8.3 0.0 2.9 3 0 0 3 3 3 0 EF hand Fanconi_A PF03511.14 ETO24145.1 - 0.096 12.6 0.1 0.21 11.5 0.1 1.5 1 0 0 1 1 1 0 Fanconi anaemia group A protein Glyco_transf_10 PF00852.19 ETO24146.1 - 1.3e-07 31.5 0.2 0.00059 19.6 0.0 2.7 3 0 0 3 3 3 2 Glycosyltransferase family 10 (fucosyltransferase) C-term p31comet PF06581.12 ETO24147.1 - 0.037 13.2 1.4 0.063 12.4 1.4 1.3 1 0 0 1 1 1 0 Mad1 and Cdc20-bound-Mad2 binding DUF3106 PF11304.8 ETO24148.1 - 0.0075 16.7 4.5 0.0075 16.7 4.5 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF3106) DUF2469 PF10611.9 ETO24148.1 - 0.032 14.8 4.5 0.055 14.0 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2469) MtrB PF05440.12 ETO24148.1 - 0.15 12.5 0.4 0.61 10.5 0.1 2.0 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase subunit B MCPsignal PF00015.21 ETO24148.1 - 0.29 10.9 5.2 0.3 10.9 3.9 1.8 1 1 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Cupin_8 PF13621.6 ETO24148.1 - 0.35 10.6 4.6 0.36 10.5 3.8 1.4 1 1 0 1 1 1 0 Cupin-like domain ZYG-11_interact PF05884.12 ETO24148.1 - 1.3 8.3 3.0 1.9 7.8 3.0 1.3 1 0 0 1 1 1 0 Interactor of ZYG-11 FPRL1_inhibitor PF16104.5 ETO24148.1 - 1.8 8.8 9.1 5 7.3 0.5 2.7 1 1 2 3 3 3 0 Formyl peptide receptor-like 1 inhibitory protein Vac_Fusion PF02346.16 ETO24148.1 - 7.8 6.2 8.0 7.2 6.3 0.0 3.0 3 1 1 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 Pkinase PF00069.25 ETO24149.1 - 3.8e-56 190.4 0.1 3.8e-56 190.4 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24149.1 - 1.3e-38 132.7 0.0 2.8e-38 131.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO24149.1 - 1.7e-05 24.3 0.0 3.1e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO24149.1 - 2.8e-05 23.6 0.2 2.8e-05 23.6 0.2 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO24149.1 - 0.00011 22.3 0.1 0.0002 21.3 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family TFIIA PF03153.13 ETO24149.1 - 0.0012 18.9 6.1 0.0014 18.7 6.1 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 ETO24149.1 - 0.022 13.3 4.1 0.024 13.2 4.1 1.1 1 0 0 1 1 1 0 Macoilin family DUF1345 PF07077.11 ETO24149.1 - 0.046 13.4 0.0 0.089 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) Choline_kinase PF01633.20 ETO24149.1 - 0.058 13.0 0.1 0.058 13.0 0.1 2.3 2 1 0 2 2 2 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ETO24149.1 - 0.082 11.8 6.2 0.16 10.9 6.2 1.5 1 1 0 1 1 1 0 Haspin like kinase domain Presenilin PF01080.17 ETO24149.1 - 0.39 9.4 3.7 0.46 9.2 3.7 1.1 1 0 0 1 1 1 0 Presenilin cNMP_binding PF00027.29 ETO24150.1 - 9.2e-23 80.1 0.0 1.3e-22 79.6 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain ATP-gua_Ptrans PF00217.19 ETO24150.1 - 0.057 12.9 0.0 0.074 12.5 0.0 1.1 1 0 0 1 1 1 0 ATP:guanido phosphotransferase, C-terminal catalytic domain tRNA_int_endo_N PF02778.14 ETO24150.1 - 0.073 12.8 0.0 0.14 11.9 0.0 1.4 1 0 0 1 1 1 0 tRNA intron endonuclease, N-terminal domain Pkinase PF00069.25 ETO24151.1 - 5.8e-09 35.7 0.1 9.4e-09 35.0 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF2559 PF10832.8 ETO24151.1 - 0.13 12.3 0.0 0.35 11.0 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2559) Pkinase PF00069.25 ETO24152.1 - 3.1e-45 154.6 0.0 4.4e-44 150.8 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24152.1 - 1.5e-17 63.7 0.0 1.7e-08 34.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO24152.1 - 0.0032 16.8 0.1 1 8.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like Seadorna_VP7 PF07387.11 ETO24152.1 - 0.056 12.5 0.0 0.08 12.0 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 RhoGAP PF00620.27 ETO24152.1 - 0.065 13.1 0.0 0.11 12.3 0.0 1.3 1 0 0 1 1 1 0 RhoGAP domain ETRAMP PF09716.10 ETO24152.1 - 0.98 9.5 6.4 0.96 9.6 0.0 2.6 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) PH PF00169.29 ETO24153.1 - 7.7e-06 26.4 0.0 3.9e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 PH domain UPF0242 PF06785.11 ETO24153.1 - 0.0028 17.8 8.4 0.0028 17.8 8.4 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Golgin_A5 PF09787.9 ETO24153.1 - 0.0084 15.6 13.1 0.0084 15.6 13.1 2.2 2 0 0 2 2 2 1 Golgin subfamily A member 5 PH_6 PF15406.6 ETO24153.1 - 0.037 14.3 0.0 0.12 12.7 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain MCC-bdg_PDZ PF10506.9 ETO24153.1 - 0.078 13.0 6.5 0.066 13.2 2.4 2.4 2 0 0 2 2 2 0 PDZ domain of MCC-2 bdg protein for Usher syndrome PH_8 PF15409.6 ETO24153.1 - 0.1 12.9 0.0 0.32 11.3 0.0 1.8 1 0 0 1 1 1 0 Pleckstrin homology domain DUF1640 PF07798.11 ETO24153.1 - 0.38 10.8 10.3 0.97 9.5 10.3 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1640) DUF4407 PF14362.6 ETO24153.1 - 0.87 8.9 6.7 1.3 8.3 6.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KfrA_N PF11740.8 ETO24153.1 - 0.93 10.2 8.1 0.37 11.5 0.4 2.4 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term DUF1664 PF07889.12 ETO24153.1 - 1.7 8.7 9.5 12 5.9 3.5 3.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Syntaxin-6_N PF09177.11 ETO24153.1 - 1.7 9.2 15.6 0.78 10.3 7.7 3.4 2 1 1 3 3 3 0 Syntaxin 6, N-terminal DUF2120 PF09893.9 ETO24153.1 - 1.8 8.7 8.0 2.5 8.2 5.4 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2120) LRR19-TM PF15176.6 ETO24153.1 - 2.2 8.4 6.9 2.6 8.1 0.1 2.9 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain DUF3323 PF11796.8 ETO24153.1 - 2.2 8.1 5.4 0.7 9.7 2.5 1.6 2 0 0 2 2 2 0 Protein of unknown function N-terminus (DUF3323) RGS PF00615.19 ETO24154.1 - 5.2e-07 30.0 0.0 2.2e-06 27.9 0.0 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain GTP_EFTU_D3 PF03143.17 ETO24155.1 - 6.5e-13 49.0 0.0 2e-11 44.2 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain 7tm_3 PF00003.22 ETO24157.1 - 7e-23 81.6 30.2 7e-23 81.6 30.2 2.1 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4713 PF15831.5 ETO24159.1 - 0.012 16.1 0.1 0.025 15.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4713) HSP70 PF00012.20 ETO24161.1 - 2.7e-05 22.6 0.0 8.7e-05 20.9 0.1 1.8 2 0 0 2 2 2 1 Hsp70 protein DDR PF08841.10 ETO24161.1 - 0.19 10.7 0.2 0.31 10.0 0.2 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain NAPRTase_N PF17767.1 ETO24162.1 - 8.5e-24 84.3 1.6 1.1e-23 84.0 1.6 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain CUE PF02845.16 ETO24162.1 - 0.15 11.8 0.0 0.28 10.9 0.0 1.5 1 0 0 1 1 1 0 CUE domain Nup54_C PF18437.1 ETO24163.1 - 0.027 14.4 0.3 0.045 13.7 0.3 1.4 1 0 0 1 1 1 0 Nup54 C-terminal interacting domain MIF4G_like_2 PF09090.11 ETO24163.1 - 0.13 11.8 2.1 0.17 11.4 2.1 1.0 1 0 0 1 1 1 0 MIF4G like MAS20 PF02064.15 ETO24163.1 - 4.6 7.4 8.3 9.8 6.3 8.3 1.6 1 1 0 1 1 1 0 MAS20 protein import receptor G-alpha PF00503.20 ETO24164.1 - 2.2e-18 66.5 0.1 2.9e-18 66.1 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit 2OG-FeII_Oxy PF03171.20 ETO24165.1 - 1.6e-14 54.2 0.0 2.8e-14 53.4 0.0 1.5 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ETO24165.1 - 8.5e-09 36.2 1.0 3.9e-08 34.1 0.0 2.4 3 0 0 3 3 3 1 non-haem dioxygenase in morphine synthesis N-terminal ThiF PF00899.21 ETO24166.1 - 4.3e-26 91.8 0.0 5.6e-26 91.4 0.0 1.1 1 0 0 1 1 1 1 ThiF family Shikimate_DH PF01488.20 ETO24166.1 - 0.0011 19.0 0.0 0.0014 18.7 0.0 1.2 1 0 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase K_oxygenase PF13434.6 ETO24166.1 - 0.024 13.8 0.0 0.026 13.7 0.0 1.1 1 0 0 1 1 1 0 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox_2 PF07992.14 ETO24166.1 - 0.14 11.3 0.0 0.14 11.3 0.0 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_7 PF13241.6 ETO24166.1 - 0.18 12.3 0.0 0.29 11.6 0.0 1.3 1 0 0 1 1 1 0 Putative NAD(P)-binding Alliinase_C PF04864.13 ETO24166.1 - 0.23 10.3 0.0 0.28 10.0 0.0 1.1 1 0 0 1 1 1 0 Allinase RPEL PF02755.15 ETO24167.1 - 0.026 14.2 0.1 0.026 14.2 0.1 5.4 6 1 0 6 6 6 0 RPEL repeat HI0933_like PF03486.14 ETO24167.1 - 0.19 10.4 1.0 0.39 9.4 1.0 1.4 1 0 0 1 1 1 0 HI0933-like protein Spermine_synt_N PF17284.2 ETO24168.1 - 0.1 12.5 0.0 3.6 7.5 0.0 2.6 2 0 0 2 2 2 0 Spermidine synthase tetramerisation domain Imm43 PF15570.6 ETO24168.1 - 0.77 9.8 8.8 0.082 12.9 3.2 2.4 2 1 0 2 2 2 0 Immunity protein 43 MIEAP PF16026.5 ETO24170.1 - 2e-05 24.9 0.8 9.5e-05 22.7 0.6 2.2 1 1 0 1 1 1 1 Mitochondria-eating protein DHquinase_II PF01220.19 ETO24170.1 - 0.003 17.2 0.1 0.54 9.9 0.0 2.3 2 0 0 2 2 2 2 Dehydroquinase class II C2 PF00168.30 ETO24171.1 - 4.7e-06 26.8 0.0 1.1e-05 25.6 0.0 1.6 1 0 0 1 1 1 1 C2 domain PDZ PF00595.24 ETO24171.1 - 0.00042 20.6 0.0 0.00097 19.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO24171.1 - 0.0044 16.8 0.0 0.0095 15.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain SUB1_ProdP9 PF18213.1 ETO24171.1 - 0.013 15.3 0.2 0.029 14.2 0.2 1.5 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 FYRC PF05965.14 ETO24172.1 - 3.6e-17 62.3 0.0 3.6e-17 62.3 0.0 1.7 2 0 0 2 2 2 1 F/Y rich C-terminus FYRN PF05964.14 ETO24172.1 - 9.7e-11 41.3 0.0 1.6e-10 40.7 0.0 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus RRXRR PF14239.6 ETO24172.1 - 2.5 7.9 10.4 1.3 8.8 8.0 1.7 2 0 0 2 2 2 0 RRXRR protein SPC25 PF06703.11 ETO24173.1 - 0.0028 17.5 0.8 0.0044 16.8 0.8 1.3 1 0 0 1 1 1 1 Microsomal signal peptidase 25 kDa subunit (SPC25) EF-hand_6 PF13405.6 ETO24173.1 - 0.0035 17.1 4.5 2 8.5 0.3 3.3 2 1 1 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO24173.1 - 0.0038 17.6 3.0 0.27 11.7 0.0 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO24173.1 - 0.004 16.6 0.6 1.4 8.7 0.0 3.1 3 0 0 3 3 3 2 EF hand Glycos_trans_3N PF02885.17 ETO24173.1 - 0.022 14.6 0.2 0.063 13.1 0.1 1.7 2 0 0 2 2 2 0 Glycosyl transferase family, helical bundle domain DUF2286 PF10051.9 ETO24174.1 - 0.053 13.3 0.0 0.096 12.4 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2286) Utp14 PF04615.13 ETO24175.1 - 0.017 13.8 7.8 0.018 13.6 7.8 1.0 1 0 0 1 1 1 0 Utp14 protein Menin PF05053.13 ETO24175.1 - 0.043 12.2 13.2 0.057 11.8 13.2 1.2 1 0 0 1 1 1 0 Menin DNA_circ_N PF07157.12 ETO24175.1 - 0.12 12.8 0.0 0.38 11.2 0.0 1.7 2 0 0 2 2 2 0 DNA circularisation protein N-terminus GREB1 PF15782.5 ETO24175.1 - 0.88 6.6 13.7 1.1 6.3 13.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer AIF_C PF14721.6 ETO24176.1 - 0.21 12.0 5.7 5.8 7.3 1.8 3.1 3 0 0 3 3 3 0 Apoptosis-inducing factor, mitochondrion-associated, C-term POX PF07526.11 ETO24176.1 - 0.53 10.8 7.0 0.45 11.1 4.0 2.1 2 0 0 2 2 2 0 Associated with HOX DUF4471 PF14740.6 ETO24176.1 - 3 7.0 13.8 0.033 13.4 4.7 2.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4471) DUF4834 PF16118.5 ETO24176.1 - 3.2 8.8 10.4 7.4 7.6 5.3 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Methyltransf_12 PF08242.12 ETO24176.1 - 6.6 7.5 6.4 0.9 10.3 1.3 2.2 2 0 0 2 2 2 0 Methyltransferase domain AP3D1 PF06375.11 ETO24176.1 - 9.4 6.5 25.4 1.2 9.4 10.3 3.0 2 1 1 3 3 3 0 AP-3 complex subunit delta-1 PH_4 PF15404.6 ETO24179.1 - 2.5 7.8 9.4 4.3 7.1 9.1 1.5 1 1 0 1 1 1 0 Pleckstrin homology domain V_ATPase_I PF01496.19 ETO24179.1 - 5 4.9 6.6 6.1 4.6 6.6 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family WD40 PF00400.32 ETO24180.1 - 2.5e-26 91.4 15.2 1.1e-06 29.2 0.4 5.9 5 0 0 5 5 5 5 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO24180.1 - 8.6e-06 26.4 2.3 8.6e-06 26.4 2.3 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO24180.1 - 0.00013 22.2 0.2 0.12 12.7 0.0 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24180.1 - 0.00017 20.4 6.0 0.11 11.1 0.5 3.4 2 2 1 3 3 3 3 Nucleoporin Nup120/160 Ion_trans_2 PF07885.16 ETO24181.1 - 1.2e-14 54.0 5.7 2e-14 53.3 5.7 1.4 1 0 0 1 1 1 1 Ion channel EF-hand_7 PF13499.6 ETO24181.1 - 5.9e-08 33.0 10.7 2e-05 25.0 4.4 2.2 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 ETO24181.1 - 6.8e-08 31.5 8.0 0.00012 21.3 0.7 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO24181.1 - 7.2e-08 31.8 3.9 0.0006 19.6 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain Ion_trans PF00520.31 ETO24181.1 - 2.3e-06 27.0 0.8 3e-06 26.6 0.8 1.2 1 0 0 1 1 1 1 Ion transport protein EF-hand_8 PF13833.6 ETO24181.1 - 0.00015 21.5 2.7 0.14 12.0 0.2 2.5 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO24181.1 - 0.00025 20.4 6.9 0.021 14.3 0.7 2.8 2 0 0 2 2 2 2 EF hand DUF2951 PF11166.8 ETO24181.1 - 0.62 10.3 0.0 0.62 10.3 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF2951) Microtub_bd PF16796.5 ETO24182.1 - 1.5e-11 44.4 0.3 1.5e-11 44.4 0.3 2.7 2 2 0 2 2 2 1 Microtubule binding SLBP_RNA_bind PF15247.6 ETO24182.1 - 0.059 13.5 0.8 2.4 8.4 0.1 2.6 2 0 0 2 2 2 0 Histone RNA hairpin-binding protein RNA-binding domain DUF2400 PF09674.10 ETO24182.1 - 1.1 9.2 8.7 1.8 8.5 4.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2400) Utp14 PF04615.13 ETO24182.1 - 7.3 5.0 30.3 0.86 8.1 4.6 2.3 2 1 0 2 2 2 0 Utp14 protein Kinesin PF00225.23 ETO24183.1 - 3.5e-09 36.0 0.2 3.7e-09 36.0 0.2 1.1 1 0 0 1 1 1 1 Kinesin motor domain Kinesin PF00225.23 ETO24184.1 - 3e-26 92.2 0.0 3.8e-26 91.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Sas6_CC PF18594.1 ETO24185.1 - 8.5 6.3 11.2 2.2 8.2 1.8 2.9 2 0 0 2 2 2 0 Sas6/XLF/XRCC4 coiled-coil domain Lge1 PF11488.8 ETO24185.1 - 8.6 6.6 19.0 0.071 13.3 5.9 3.3 3 1 0 3 3 3 0 Transcriptional regulatory protein LGE1 EBP50_C PF09007.11 ETO24186.1 - 9.8 7.2 9.8 1.5 9.8 1.3 2.9 2 1 0 2 2 2 0 EBP50, C-terminal NAD_synthase PF02540.17 ETO24187.1 - 2.9e-12 46.2 0.1 5.9e-12 45.2 0.0 1.6 2 0 0 2 2 2 1 NAD synthase SAM_1 PF00536.30 ETO24188.1 - 3.4e-06 27.4 0.1 6.3e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO24188.1 - 1.5e-05 25.0 0.1 2.8e-05 24.2 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) LIM PF00412.22 ETO24188.1 - 0.00075 19.7 5.4 0.0013 18.9 5.4 1.5 1 0 0 1 1 1 1 LIM domain zf-HYPF PF07503.12 ETO24188.1 - 0.54 10.1 9.4 0.37 10.6 6.3 2.3 2 1 0 2 2 2 0 HypF finger OAD_gamma PF04277.13 ETO24188.1 - 4.8 7.9 5.8 80 3.9 1.1 3.0 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain zf-AD PF07776.15 ETO24188.1 - 9.1 6.6 9.3 3.2 8.1 0.2 3.7 4 1 0 4 4 4 0 Zinc-finger associated domain (zf-AD) G-alpha PF00503.20 ETO24189.1 - 7.9e-24 84.5 2.1 9.8e-24 84.2 2.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit AAA_16 PF13191.6 ETO24189.1 - 0.0064 16.9 0.0 0.0088 16.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_14 PF13173.6 ETO24189.1 - 0.017 15.1 0.1 0.042 13.9 0.1 1.8 1 0 0 1 1 1 0 AAA domain Roc PF08477.13 ETO24189.1 - 0.025 14.8 5.8 0.048 13.9 0.9 3.1 2 2 1 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO24189.1 - 0.028 13.9 0.1 0.06 12.8 0.1 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_29 PF13555.6 ETO24189.1 - 0.036 13.8 0.0 0.13 12.0 0.0 2.0 1 0 0 1 1 1 0 P-loop containing region of AAA domain ATPase_2 PF01637.18 ETO24189.1 - 0.038 13.9 0.5 1 9.2 0.0 2.1 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_18 PF13238.6 ETO24189.1 - 0.051 14.1 1.2 0.18 12.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO24189.1 - 0.079 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family SRPRB PF09439.10 ETO24189.1 - 0.091 12.2 0.1 0.17 11.3 0.1 1.4 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO24189.1 - 0.1 12.7 0.1 0.32 11.1 0.0 1.9 2 0 0 2 2 2 0 50S ribosome-binding GTPase DUF2547 PF10818.8 ETO24189.1 - 0.96 10.4 3.3 1.4 9.9 0.3 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2547) WD40 PF00400.32 ETO24190.1 - 0.79 10.7 3.5 8.7 7.4 0.0 3.1 3 0 0 3 3 3 0 WD domain, G-beta repeat Peptidase_S10 PF00450.22 ETO24192.1 - 1.6e-13 50.8 0.0 1.2e-10 41.4 0.0 2.1 2 0 0 2 2 2 2 Serine carboxypeptidase Ank_2 PF12796.7 ETO24193.1 - 1.9e-33 114.9 7.9 3.4e-12 46.8 0.0 3.6 1 1 3 4 4 4 4 Ankyrin repeats (3 copies) Ank PF00023.30 ETO24193.1 - 6.4e-20 70.6 0.3 0.00016 22.0 0.0 6.5 7 0 0 7 7 7 4 Ankyrin repeat Ank_4 PF13637.6 ETO24193.1 - 1.2e-18 67.2 0.4 7e-06 26.5 0.0 4.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO24193.1 - 3.7e-17 62.2 0.7 1.5e-06 28.3 0.0 5.8 3 2 4 7 7 7 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO24193.1 - 8.7e-16 56.4 0.8 0.32 11.7 0.0 6.9 7 1 0 7 7 7 4 Ankyrin repeat Ribosomal_S6 PF01250.17 ETO24193.1 - 0.028 14.7 0.0 1 9.6 0.0 3.0 2 1 1 3 3 3 0 Ribosomal protein S6 EBA-175_VI PF11556.8 ETO24193.1 - 3.4 8.1 11.8 7.1 7.0 2.3 2.8 2 1 0 2 2 2 0 Erythrocyte binding antigen 175 Iron_permease PF04120.12 ETO24194.1 - 0.034 13.9 0.7 0.044 13.5 0.7 1.1 1 0 0 1 1 1 0 Low affinity iron permease TBCA PF02970.16 ETO24194.1 - 0.072 13.4 1.8 0.088 13.2 1.8 1.2 1 0 0 1 1 1 0 Tubulin binding cofactor A UDPGP PF01704.18 ETO24198.1 - 6e-07 28.5 0.0 7e-07 28.2 0.0 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase OAS1_C PF10421.9 ETO24199.1 - 0.0018 17.8 2.4 0.46 10.0 0.1 2.7 2 1 1 3 3 3 2 2'-5'-oligoadenylate synthetase 1, domain 2, C-terminus PAP_assoc PF03828.19 ETO24199.1 - 0.0074 16.5 2.2 0.018 15.3 2.2 1.7 1 0 0 1 1 1 1 Cid1 family poly A polymerase tRNA_NucTransf2 PF09249.11 ETO24199.1 - 0.027 14.7 0.0 0.071 13.4 0.0 1.7 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain G8 PF10162.9 ETO24200.1 - 0.073 13.2 0.1 0.14 12.3 0.1 1.5 1 0 0 1 1 1 0 G8 domain Ank_2 PF12796.7 ETO24204.1 - 1.7e-26 92.6 0.7 1.7e-11 44.6 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank PF00023.30 ETO24204.1 - 1.8e-17 62.9 0.2 0.0003 21.1 0.0 4.3 4 0 0 4 4 4 4 Ankyrin repeat Ank_3 PF13606.6 ETO24204.1 - 8.8e-15 53.4 0.0 0.0011 19.3 0.0 4.9 5 0 0 5 5 5 4 Ankyrin repeat Ank_4 PF13637.6 ETO24204.1 - 5.4e-11 42.8 0.8 0.00061 20.3 0.1 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO24204.1 - 5.4e-10 39.3 0.1 0.003 17.8 0.0 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) HTH_45 PF14947.6 ETO24204.1 - 0.032 14.2 0.2 2.2 8.3 0.0 2.9 2 2 0 2 2 2 0 Winged helix-turn-helix OmpH PF03938.14 ETO24205.1 - 0.0079 16.5 19.5 0.0079 16.5 19.5 4.8 2 1 2 4 4 4 2 Outer membrane protein (OmpH-like) Tup_N PF08581.10 ETO24205.1 - 0.015 15.6 4.3 0.015 15.6 4.3 6.0 4 2 1 5 5 5 0 Tup N-terminal SUIM_assoc PF16619.5 ETO24205.1 - 0.026 14.6 9.3 0.026 14.6 9.3 4.0 3 1 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 ZapB PF06005.12 ETO24205.1 - 0.029 14.8 12.1 0.029 14.8 12.1 6.0 4 1 1 5 5 5 0 Cell division protein ZapB TSC22 PF01166.18 ETO24205.1 - 0.035 14.4 1.0 0.035 14.4 1.0 5.3 5 2 1 6 6 6 0 TSC-22/dip/bun family YvrJ PF12841.7 ETO24205.1 - 0.1 12.2 1.8 9.4 5.9 0.3 3.1 2 0 0 2 2 2 0 YvrJ protein family Collagen_mid PF15984.5 ETO24205.1 - 0.16 11.7 0.4 0.25 11.1 0.4 1.2 1 0 0 1 1 1 0 Bacterial collagen, middle region PRD PF00874.20 ETO24205.1 - 2.1 8.7 21.4 2.1 8.7 0.6 3.9 2 1 1 3 3 3 0 PRD domain Golgin_A5 PF09787.9 ETO24205.1 - 9.2 5.6 74.0 0.015 14.8 22.5 3.8 2 1 2 4 4 4 0 Golgin subfamily A member 5 G-gamma PF00631.22 ETO24206.1 - 0.012 15.6 0.4 1.3 9.1 0.2 3.2 2 0 0 2 2 2 0 GGL domain DUF1664 PF07889.12 ETO24206.1 - 0.012 15.6 2.5 0.012 15.6 2.5 4.7 3 2 1 4 4 4 0 Protein of unknown function (DUF1664) ATG16 PF08614.11 ETO24206.1 - 5.8 7.1 57.9 0.47 10.6 10.8 4.7 3 2 0 3 3 3 0 Autophagy protein 16 (ATG16) SAM_2 PF07647.17 ETO24207.1 - 0.025 14.7 0.1 0.025 14.7 0.1 2.0 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO24210.1 - 1.7e-67 221.7 19.5 4.6e-10 39.9 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24210.1 - 2.8e-24 85.2 1.6 0.00012 22.3 0.0 6.4 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24210.1 - 4.4e-13 48.9 0.3 0.2 10.5 0.0 6.9 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO24210.1 - 6.7e-11 42.1 1.7 0.0037 16.6 0.1 4.2 2 1 2 4 4 4 3 WD40-like domain eIF2A PF08662.11 ETO24210.1 - 3.3e-09 36.9 0.3 0.0014 18.5 0.1 3.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO24210.1 - 9e-09 34.5 5.9 1 7.9 0.0 6.3 3 3 3 7 7 7 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO24210.1 - 2e-07 29.9 0.3 0.0061 15.1 0.1 3.3 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO24210.1 - 1.2e-05 25.0 5.6 1.6 8.8 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Resistin PF06954.11 ETO24210.1 - 1.6e-05 25.3 0.2 0.47 11.0 0.1 4.7 4 2 2 6 6 6 1 Resistin Nucleoporin_N PF08801.11 ETO24210.1 - 0.00025 19.9 8.4 0.094 11.4 4.3 4.1 2 2 1 3 3 3 1 Nup133 N terminal like Me-amine-dh_H PF06433.11 ETO24210.1 - 0.00076 18.4 0.0 0.95 8.3 0.0 3.0 2 1 2 4 4 4 2 Methylamine dehydrogenase heavy chain (MADH) Nbas_N PF15492.6 ETO24210.1 - 0.0011 18.3 0.8 1.7 7.9 0.0 3.8 1 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO24210.1 - 0.0036 17.4 0.3 13 5.9 0.0 4.2 2 2 1 4 4 4 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO24210.1 - 0.077 12.7 7.5 8.4 6.2 0.0 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DHFR_2 PF06442.11 ETO24210.1 - 0.091 12.6 0.0 5.4 6.9 0.0 3.0 3 1 0 3 3 3 0 R67 dihydrofolate reductase VID27 PF08553.10 ETO24210.1 - 0.098 11.7 0.0 5 6.1 0.0 2.9 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain Tyrosinase PF00264.20 ETO24212.1 - 5.6e-19 69.3 1.9 5.6e-19 69.3 1.9 2.0 2 0 0 2 2 2 1 Common central domain of tyrosinase WD40 PF00400.32 ETO24213.1 - 6e-61 201.0 23.4 1.3e-10 41.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24213.1 - 5.2e-23 81.2 5.1 8.8e-05 22.7 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24213.1 - 4.8e-14 52.1 0.6 0.025 13.6 0.0 6.5 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO24213.1 - 3.2e-11 43.1 5.2 0.00054 19.4 0.1 3.1 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO24213.1 - 4.5e-08 32.2 6.7 0.27 9.8 0.0 5.5 2 2 4 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO24213.1 - 1.5e-05 23.7 3.5 0.026 13.0 0.5 2.8 1 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO24213.1 - 3.3e-05 24.0 0.9 0.081 13.0 0.1 4.1 2 1 2 5 5 5 1 Family of unknown function (DUF5570) BBS2_Mid PF14783.6 ETO24213.1 - 0.0016 18.4 2.0 11 6.1 0.0 5.0 2 1 4 6 6 6 1 Ciliary BBSome complex subunit 2, middle region VID27 PF08553.10 ETO24213.1 - 0.016 14.3 0.6 0.4 9.7 0.0 2.9 2 1 1 3 3 3 0 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO24213.1 - 0.022 14.7 14.2 3.4 7.7 0.6 5.7 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO24213.1 - 0.028 14.3 0.0 24 5.1 0.0 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat DPPIV_N PF00930.21 ETO24213.1 - 0.053 12.3 0.3 12 4.6 0.1 2.9 2 2 0 2 2 2 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pkinase PF00069.25 ETO24215.1 - 1.3e-22 80.4 0.0 3.4e-22 79.1 0.0 1.6 1 1 0 1 1 1 1 Protein kinase domain DUF1981 PF09324.10 ETO24216.1 - 3.5e-11 42.8 0.6 1.4e-09 37.6 0.2 3.0 3 0 0 3 3 3 1 Domain of unknown function (DUF1981) Mit_KHE1 PF10173.9 ETO24216.1 - 0.016 15.3 1.2 0.027 14.5 0.3 1.9 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related MqsR_toxin PF15723.5 ETO24216.1 - 0.11 12.9 1.9 8.3 6.9 0.2 2.4 2 0 0 2 2 2 0 Motility quorum-sensing regulator, toxin of MqsA DUF3627 PF12299.8 ETO24216.1 - 0.5 10.5 3.0 20 5.3 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3627) Mon2_C PF16206.5 ETO24217.1 - 2.2e-18 65.8 0.1 2.7e-18 65.6 0.1 1.0 1 0 0 1 1 1 1 C-terminal region of Mon2 protein Spt20 PF12090.8 ETO24217.1 - 0.0002 21.0 16.7 0.00031 20.4 16.7 1.2 1 0 0 1 1 1 1 Spt20 family Ipi1_N PF12333.8 ETO24217.1 - 0.0019 18.8 4.7 0.15 12.7 0.0 2.2 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation Med3 PF11593.8 ETO24217.1 - 0.002 17.4 9.2 0.0024 17.1 9.2 1.1 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal FAM176 PF14851.6 ETO24217.1 - 0.0065 16.1 3.8 0.0094 15.6 3.8 1.2 1 0 0 1 1 1 1 FAM176 family TERB2 PF15101.6 ETO24217.1 - 0.0084 16.2 2.7 0.0092 16.1 2.7 1.2 1 0 0 1 1 1 1 Telomere-associated protein TERB2 FAM91_C PF14648.6 ETO24217.1 - 0.0086 15.0 0.4 0.0093 14.8 0.4 1.1 1 0 0 1 1 1 1 FAM91 C-terminus AIF_C PF14721.6 ETO24217.1 - 0.018 15.4 2.5 0.04 14.3 2.4 1.7 1 1 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF702 PF05142.12 ETO24217.1 - 0.019 15.5 2.5 0.022 15.2 2.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF702) TFIIA PF03153.13 ETO24217.1 - 0.021 14.8 10.5 0.023 14.7 10.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DDHD PF02862.17 ETO24217.1 - 0.023 14.9 0.7 0.023 14.9 0.7 1.1 1 0 0 1 1 1 0 DDHD domain Med15 PF09606.10 ETO24217.1 - 0.025 13.3 9.8 0.031 13.0 9.8 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal PEX11 PF05648.14 ETO24217.1 - 0.025 14.1 2.3 0.17 11.3 1.3 2.1 2 0 0 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) DUF1764 PF08576.10 ETO24217.1 - 0.049 14.5 6.6 0.073 14.0 6.6 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) FemAB PF02388.16 ETO24217.1 - 0.049 12.5 5.2 0.065 12.1 5.2 1.1 1 0 0 1 1 1 0 FemAB family CLN3 PF02487.17 ETO24217.1 - 0.057 12.5 0.7 0.068 12.2 0.7 1.2 1 0 0 1 1 1 0 CLN3 protein DUF2722 PF10846.8 ETO24217.1 - 0.08 11.9 17.6 0.11 11.5 17.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Mem_trans PF03547.18 ETO24217.1 - 0.1 11.0 0.2 0.093 11.1 0.2 1.2 1 0 0 1 1 1 0 Membrane transport protein Presenilin PF01080.17 ETO24217.1 - 0.15 10.8 3.3 0.18 10.5 3.3 1.2 1 0 0 1 1 1 0 Presenilin VIT1 PF01988.19 ETO24217.1 - 0.19 11.6 0.3 0.22 11.4 0.3 1.3 1 0 0 1 1 1 0 VIT family EIIBC-GUT_N PF03612.14 ETO24217.1 - 0.66 9.7 3.1 0.91 9.2 3.1 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3464 PF11947.8 ETO24217.1 - 1.1 9.0 5.9 2.1 8.1 5.9 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 GTA_holin_3TM PF11351.8 ETO24217.1 - 1.9 9.1 5.2 4.3 7.9 5.2 1.6 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release Pex24p PF06398.11 ETO24217.1 - 3.1 6.7 8.8 2.8 6.8 2.9 2.0 1 1 0 2 2 2 0 Integral peroxisomal membrane peroxin Androgen_recep PF02166.16 ETO24217.1 - 4.9 5.9 12.5 6 5.6 12.5 1.1 1 0 0 1 1 1 0 Androgen receptor DUF4834 PF16118.5 ETO24217.1 - 7.3 7.6 14.7 0.049 14.6 5.5 2.0 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) Mon2_C PF16206.5 ETO24219.1 - 0.00033 19.0 0.2 0.0073 14.5 0.2 2.1 1 1 0 1 1 1 1 C-terminal region of Mon2 protein PA28_beta PF02252.18 ETO24223.1 - 2.7e-41 140.6 0.8 2.7e-41 140.6 0.8 1.8 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETO24223.1 - 0.00052 20.0 0.4 0.0016 18.4 0.4 1.9 1 1 0 1 1 1 1 Proteasome activator pa28 alpha subunit Inos-1-P_synth PF01658.17 ETO24223.1 - 2.9 8.2 7.9 0.47 10.7 3.5 2.0 1 1 1 2 2 2 0 Myo-inositol-1-phosphate synthase Ring_hydroxyl_A PF00848.19 ETO24224.1 - 0.042 13.8 3.2 0.067 13.2 3.2 1.3 1 1 0 1 1 1 0 Ring hydroxylating alpha subunit (catalytic domain) OAD_gamma PF04277.13 ETO24225.1 - 1.7 9.3 5.5 11 6.6 0.1 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Kelch_1 PF01344.25 ETO24226.1 - 2.5e-08 33.3 1.2 0.0013 18.2 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO24226.1 - 4.6e-06 26.7 0.4 0.21 12.0 0.0 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO24226.1 - 2e-05 24.4 2.9 0.17 11.9 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO24226.1 - 0.00025 21.0 0.4 0.0069 16.4 0.0 3.0 3 0 0 3 3 3 1 Kelch motif Nbs1_C PF08599.10 ETO24226.1 - 0.0018 18.4 0.7 0.0054 16.8 0.7 1.8 1 0 0 1 1 1 1 DNA damage repair protein Nbs1 DUF2272 PF10030.9 ETO24226.1 - 0.0082 15.9 1.5 1.5 8.5 0.1 2.6 3 0 0 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_3 PF13415.6 ETO24226.1 - 0.05 13.9 0.0 0.41 11.0 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO24226.1 - 0.13 12.3 0.4 0.13 12.3 0.4 4.0 5 1 0 5 5 5 0 Galactose oxidase, central domain WD40 PF00400.32 ETO24227.1 - 9.9e-41 137.0 18.8 2.8e-09 37.5 0.2 7.1 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24227.1 - 8.4e-13 48.4 5.1 0.0018 18.6 0.0 4.6 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24227.1 - 3e-10 39.6 0.6 0.046 12.7 0.0 5.1 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO24227.1 - 1.6e-07 30.4 9.2 0.048 12.3 1.7 4.3 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO24227.1 - 0.0001 21.8 0.8 0.34 10.2 0.1 3.1 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal SUKH_6 PF14568.6 ETO24227.1 - 0.06 13.8 1.3 20 5.6 0.3 3.6 1 1 1 3 3 3 0 SMI1-KNR4 cell-wall PD40 PF07676.12 ETO24227.1 - 4.3 7.4 8.0 8.3 6.5 0.1 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat IMPDH PF00478.25 ETO24228.1 - 5.6e-126 420.2 7.0 5.8e-48 163.6 2.1 3.0 3 0 0 3 3 3 3 IMP dehydrogenase / GMP reductase domain CBS PF00571.28 ETO24228.1 - 1.8e-12 47.5 0.1 4.2e-05 23.9 0.0 2.7 2 0 0 2 2 2 2 CBS domain FMN_dh PF01070.18 ETO24228.1 - 2.4e-05 23.6 0.1 4.2e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase NMO PF03060.15 ETO24228.1 - 0.0013 18.2 1.2 2.5 7.4 0.0 3.0 3 0 0 3 3 3 2 Nitronate monooxygenase His_biosynth PF00977.21 ETO24228.1 - 0.0023 17.5 0.5 1.6 8.2 0.0 3.1 2 1 1 3 3 3 2 Histidine biosynthesis protein DUF647 PF04884.14 ETO24229.1 - 9.6e-50 169.5 4.2 6.9e-34 117.5 0.2 2.2 2 0 0 2 2 2 2 Vitamin B6 photo-protection and homoeostasis FtsX PF02687.21 ETO24229.1 - 2.1 8.9 11.0 0.39 11.2 4.3 2.4 2 0 0 2 2 2 0 FtsX-like permease family Lactamase_B_6 PF16661.5 ETO24230.1 - 2.5e-42 144.5 0.0 3.4e-42 144.1 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain Lactamase_B_2 PF12706.7 ETO24230.1 - 0.0018 17.8 0.0 0.0027 17.3 0.0 1.3 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Beta-Casp PF10996.8 ETO24230.1 - 0.003 17.8 0.0 0.0061 16.8 0.0 1.5 1 0 0 1 1 1 1 Beta-Casp domain Lactamase_B PF00753.27 ETO24230.1 - 0.014 15.4 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Metallo-beta-lactamase superfamily Beta_lactamase3 PF17030.5 ETO24230.1 - 0.061 12.5 0.0 0.094 11.9 0.0 1.3 1 0 0 1 1 1 0 Putative beta-lactamase-like family Integrin_beta PF00362.18 ETO24230.1 - 0.23 11.1 0.9 0.3 10.7 0.1 1.5 2 0 0 2 2 2 0 Integrin beta chain VWA domain zf-DBF PF07535.12 ETO24231.1 - 0.0017 18.4 0.7 0.0054 16.8 0.7 1.8 1 0 0 1 1 1 1 DBF zinc finger DUF3069 PF11269.8 ETO24231.1 - 0.075 13.3 1.3 0.29 11.4 0.2 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3069) SHMT PF00464.19 ETO24232.1 - 3.7e-184 611.9 0.0 4.4e-184 611.7 0.0 1.1 1 0 0 1 1 1 1 Serine hydroxymethyltransferase OB_NTP_bind PF07717.16 ETO24232.1 - 0.15 12.4 0.0 1.4 9.3 0.0 2.3 2 0 0 2 2 2 0 Oligonucleotide/oligosaccharide-binding (OB)-fold DUF3605 PF12239.8 ETO24233.1 - 1e-12 48.6 1.5 1e-12 48.6 1.5 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3605) Lep_receptor_Ig PF06328.11 ETO24233.1 - 0.055 13.4 0.6 0.16 11.9 0.5 1.8 1 1 0 1 1 1 0 Ig-like C2-type domain DEAD PF00270.29 ETO24234.1 - 6.7e-14 52.0 0.0 3.6e-13 49.7 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO24234.1 - 9.9e-06 25.7 0.2 0.00012 22.1 0.1 2.8 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO24234.1 - 0.0062 16.9 0.4 0.19 12.1 0.1 3.1 2 1 0 2 2 2 1 Helicase conserved C-terminal domain AAA PF00004.29 ETO24234.1 - 0.012 16.0 0.1 0.039 14.4 0.1 1.8 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DNA_pol_A PF00476.20 ETO24236.1 - 2.9e-13 49.6 0.0 1.6e-12 47.2 0.0 2.1 1 1 0 1 1 1 1 DNA polymerase family A DNA_pol_A_exo1 PF01612.20 ETO24236.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 3'-5' exonuclease DNA_pol_A PF00476.20 ETO24237.1 - 2.8e-61 207.7 1.4 3.5e-61 207.3 1.4 1.1 1 0 0 1 1 1 1 DNA polymerase family A Gp-FAR-1 PF05823.12 ETO24237.1 - 0.019 15.3 1.2 0.11 12.9 0.4 2.3 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) IL2 PF00715.17 ETO24237.1 - 0.071 13.0 2.4 0.11 12.5 0.1 2.3 2 1 0 2 2 2 0 Interleukin 2 DUF2746 PF10874.8 ETO24237.1 - 0.11 12.9 0.0 0.22 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2746) Citrate_synt PF00285.21 ETO24238.1 - 1.3e-28 100.1 0.0 1.8e-28 99.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF2207 PF09972.9 ETO24239.1 - 0.0067 15.3 0.9 0.0089 14.8 0.9 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) NPR3 PF03666.13 ETO24239.1 - 0.06 12.1 6.2 0.065 12.0 6.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-LITAF-like PF10601.9 ETO24239.1 - 0.1 12.9 8.3 0.16 12.3 8.3 1.3 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain Borrelia_P83 PF05262.11 ETO24239.1 - 0.18 10.3 16.1 0.21 10.1 16.1 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Dsh_C PF12316.8 ETO24239.1 - 0.74 10.2 2.5 0.86 10.0 2.5 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal DUF4407 PF14362.6 ETO24239.1 - 1.6 8.0 10.1 3.4 6.9 10.1 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) SOBP PF15279.6 ETO24239.1 - 1.7 9.2 8.2 2.1 8.9 8.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein MDM1 PF15501.6 ETO24239.1 - 1.7 7.7 17.9 2.1 7.4 17.9 1.0 1 0 0 1 1 1 0 Nuclear protein MDM1 eIF-3c_N PF05470.12 ETO24239.1 - 1.8 6.7 15.8 2.4 6.3 15.8 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus DUF2828 PF11443.8 ETO24239.1 - 3.3 5.7 10.6 4.1 5.4 10.6 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) CDC45 PF02724.14 ETO24239.1 - 3.7 5.7 10.1 3.8 5.7 10.1 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 ETO24239.1 - 3.7 6.3 6.8 4.9 5.9 6.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2052 PF09747.9 ETO24239.1 - 4.5 7.4 13.4 6.4 6.9 13.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Pox_Ag35 PF03286.14 ETO24239.1 - 5.7 6.7 19.4 7.7 6.2 19.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rtf2 PF04641.12 ETO24239.1 - 5.7 6.2 20.6 8.3 5.7 20.6 1.2 1 0 0 1 1 1 0 Rtf2 RING-finger SLC12 PF03522.15 ETO24239.1 - 6.8 5.6 11.1 8.3 5.3 11.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 ETO24239.1 - 9.8 5.9 17.8 13 5.5 17.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 ABC2_membrane_3 PF12698.7 ETO24239.1 - 9.9 5.2 9.1 18 4.3 9.0 1.5 1 1 0 1 1 1 0 ABC-2 family transporter protein ORC3_N PF07034.11 ETO24240.1 - 0.0021 17.2 0.2 0.0023 17.1 0.2 1.1 1 0 0 1 1 1 1 Origin recognition complex (ORC) subunit 3 N-terminus Kelch_1 PF01344.25 ETO24241.1 - 0.005 16.4 3.1 2.7 7.7 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO24241.1 - 0.069 13.2 1.5 20 5.3 0.1 3.5 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO24241.1 - 1.1 9.4 0.0 1.1 9.4 0.0 3.3 3 1 1 4 4 4 0 Galactose oxidase, central domain zf-C2H2 PF00096.26 ETO24242.1 - 0.26 11.8 7.4 0.36 11.4 0.4 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO24242.1 - 5.4 8.1 12.1 24 6.1 4.7 2.9 2 0 0 2 2 2 0 C2H2-type zinc finger FAD_binding_3 PF01494.19 ETO24243.1 - 0.00087 18.6 0.0 9.6 5.3 0.0 4.0 4 0 0 4 4 4 3 FAD binding domain Apis_Csd PF11671.8 ETO24243.1 - 0.41 10.6 11.2 0.88 9.6 11.2 1.5 1 0 0 1 1 1 0 Complementary sex determiner protein SPRY PF00622.28 ETO24244.1 - 0.01 15.9 0.0 0.019 15.1 0.0 1.4 1 0 0 1 1 1 0 SPRY domain DIM1 PF02966.16 ETO24245.1 - 4.8e-45 152.6 1.0 5.4e-45 152.4 1.0 1.0 1 0 0 1 1 1 1 Mitosis protein DIM1 CAMP_factor PF07373.11 ETO24246.1 - 0.016 14.8 0.0 0.022 14.4 0.0 1.1 1 0 0 1 1 1 0 CAMP factor (Cfa) DUF2721 PF11026.8 ETO24247.1 - 0.018 15.0 0.0 0.026 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2721) Endotoxin_N PF03945.14 ETO24247.1 - 0.061 13.0 0.1 0.077 12.7 0.1 1.1 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain FliG_M PF14841.6 ETO24247.1 - 0.14 12.4 0.5 4.5 7.6 0.5 2.7 2 1 0 2 2 2 0 FliG middle domain DUF3584 PF12128.8 ETO24248.1 - 0.056 11.0 33.3 0.07 10.7 33.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Spc7 PF08317.11 ETO24248.1 - 0.31 9.9 39.3 2 7.2 36.8 2.2 1 1 0 1 1 1 0 Spc7 kinetochore protein EzrA PF06160.12 ETO24248.1 - 0.44 8.6 33.4 0.34 9.0 4.8 2.2 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA DUF3450 PF11932.8 ETO24248.1 - 0.68 9.2 42.1 0.76 9.0 25.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) IL3 PF02059.15 ETO24248.1 - 1.5 8.9 11.7 0.14 12.3 2.5 2.6 1 1 1 2 2 2 0 Interleukin-3 APG6_N PF17675.1 ETO24248.1 - 2.9 8.4 49.2 32 5.1 21.8 3.0 1 1 1 2 2 2 0 Apg6 coiled-coil region Nore1-SARAH PF16517.5 ETO24248.1 - 2.9 7.9 0.0 2.9 7.9 0.0 3.8 4 0 0 4 4 4 0 Novel Ras effector 1 C-terminal SARAH (Sav/Rassf/Hpo) domain DUF3287 PF11690.8 ETO24248.1 - 3.2 7.5 14.1 0.95 9.2 3.1 2.9 1 1 1 3 3 3 0 Protein of unknown function (DUF3287) Cucumo_2B PF03263.13 ETO24248.1 - 3.3 8.2 5.6 6.5 7.3 0.3 3.0 3 0 0 3 3 3 0 Cucumovirus protein 2B DUF1664 PF07889.12 ETO24248.1 - 6.2 6.9 23.4 0.89 9.6 8.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) ERM PF00769.19 ETO24248.1 - 6.7 6.4 40.9 26 4.5 40.9 1.8 1 1 0 1 1 1 0 Ezrin/radixin/moesin family LRRFIP PF09738.9 ETO24248.1 - 8.5 5.8 34.5 0.35 10.3 16.2 2.5 1 1 1 2 2 2 0 LRRFIP family Leu_zip PF15294.6 ETO24248.1 - 9.2 5.7 34.7 2.5 7.6 20.9 1.9 1 1 1 2 2 2 0 Leucine zipper fn3 PF00041.21 ETO24249.1 - 1.2e-13 51.2 1.7 5.6e-09 36.2 0.3 2.6 3 0 0 3 3 3 2 Fibronectin type III domain fn3_2 PF16893.5 ETO24249.1 - 0.00084 19.4 2.0 0.38 10.9 0.1 3.5 3 1 1 4 4 4 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ETO24249.1 - 0.14 12.7 1.5 5.9 7.5 0.2 2.7 2 2 0 2 2 2 0 Purple acid Phosphatase, N-terminal domain TPR_14 PF13428.6 ETO24250.1 - 0.094 13.6 0.5 6.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Tetratricopeptide repeat SAM_2 PF07647.17 ETO24252.1 - 4.7e-13 49.0 5.4 7.5e-06 26.0 0.3 3.0 3 0 0 3 3 3 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO24252.1 - 2.9e-12 46.8 2.6 1e-05 25.9 0.3 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO24252.1 - 1e-06 28.6 0.7 0.064 13.2 0.0 3.7 3 0 0 3 3 3 2 Sterile alpha motif (SAM)/Pointed domain zf-MYND PF01753.18 ETO24252.1 - 2.7e-05 24.2 15.0 7e-05 22.8 15.0 1.7 1 0 0 1 1 1 1 MYND finger Atrophin-1 PF03154.15 ETO24252.1 - 0.11 10.8 26.8 0.23 9.7 3.5 2.4 2 0 0 2 2 2 0 Atrophin-1 family G-alpha PF00503.20 ETO24254.1 - 1e-08 34.8 1.4 1.5e-08 34.3 1.4 1.2 1 0 0 1 1 1 1 G-protein alpha subunit DUF5505 PF17610.2 ETO24254.1 - 0.0025 17.8 0.0 0.0043 17.1 0.0 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF5505) NB-ARC PF00931.22 ETO24254.1 - 0.016 14.4 0.8 0.028 13.6 0.8 1.4 1 1 0 1 1 1 0 NB-ARC domain AAA_18 PF13238.6 ETO24254.1 - 0.1 13.1 0.1 0.2 12.2 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ETO24254.1 - 0.16 12.2 0.0 0.28 11.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain ubiquitin PF00240.23 ETO24256.1 - 2.7e-22 78.3 2.9 1.4e-19 69.6 1.2 3.2 3 0 0 3 3 3 2 Ubiquitin family Rad60-SLD PF11976.8 ETO24256.1 - 2.5e-08 33.6 1.7 2.4e-06 27.3 0.7 2.9 2 1 0 3 3 3 2 Ubiquitin-2 like Rad60 SUMO-like PAT1 PF09770.9 ETO24257.1 - 1.6 6.9 10.5 2.2 6.5 10.5 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 LicD PF04991.13 ETO24258.1 - 0.014 15.5 3.2 0.017 15.3 3.2 1.1 1 0 0 1 1 1 0 LicD family PBP_N PF17093.5 ETO24258.1 - 0.16 12.2 0.0 0.28 11.5 0.0 1.4 1 0 0 1 1 1 0 Penicillin-binding protein N-terminus ASL_C PF08328.11 ETO24258.1 - 0.18 11.9 3.0 0.25 11.5 3.0 1.2 1 0 0 1 1 1 0 Adenylosuccinate lyase C-terminal Jagunal PF07086.12 ETO24260.1 - 0.00011 22.3 3.1 0.00033 20.8 3.1 1.8 1 1 0 1 1 1 1 Jagunal, ER re-organisation during oogenesis DUF2530 PF10745.9 ETO24260.1 - 0.14 12.4 0.6 0.31 11.3 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2530) TMEM107 PF14995.6 ETO24260.1 - 0.21 12.0 5.0 0.56 10.7 5.0 1.8 1 1 0 1 1 1 0 Transmembrane protein CD36 PF01130.21 ETO24261.1 - 3.2e-68 230.4 12.2 3.5e-35 121.4 4.4 2.9 2 1 1 3 3 3 3 CD36 family TMCO5 PF14992.6 ETO24261.1 - 2.5 7.6 4.6 3.8 7.0 4.6 1.2 1 0 0 1 1 1 0 TMCO5 family RGS PF00615.19 ETO24262.1 - 9.8e-05 22.6 0.2 0.0016 18.7 0.2 2.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain WD40 PF00400.32 ETO24263.1 - 2e-38 129.7 35.9 6e-08 33.2 0.3 8.4 9 1 0 9 9 9 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24263.1 - 3.5e-14 52.8 0.2 0.00095 19.4 0.0 5.6 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24263.1 - 2.3e-09 36.5 3.2 0.046 12.4 0.1 5.4 3 2 3 6 6 6 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO24263.1 - 2.3e-05 25.0 1.7 0.00012 22.7 1.7 2.4 1 0 0 1 1 1 1 TRAF-type zinc finger WD40_like PF17005.5 ETO24263.1 - 0.00055 19.4 2.9 0.18 11.1 0.1 3.8 3 1 0 3 3 3 1 WD40-like domain YfhO PF09586.10 ETO24263.1 - 0.22 9.7 16.3 0.3 9.3 16.3 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO TPR_MLP1_2 PF07926.12 ETO24263.1 - 0.23 11.5 29.9 0.14 12.2 16.1 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO24263.1 - 0.24 10.7 12.5 0.38 10.1 12.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FapA PF03961.13 ETO24263.1 - 0.58 8.7 18.0 1.4 7.5 18.0 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A zf-RRN7 PF11781.8 ETO24263.1 - 2.2 8.0 4.6 4 7.2 0.1 3.3 4 0 0 4 4 4 0 Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7 RSRP PF17069.5 ETO24265.1 - 1.4e-05 24.9 38.2 1.4e-05 24.9 38.2 2.1 2 0 0 2 2 2 1 Arginine/Serine-Rich protein 1 SapB_1 PF05184.15 ETO24265.1 - 0.32 11.1 2.6 2.5 8.2 0.4 2.9 2 0 0 2 2 2 0 Saposin-like type B, region 1 DUF2207 PF09972.9 ETO24267.1 - 0.01 14.6 0.9 0.013 14.3 0.9 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 ETO24267.1 - 0.028 14.7 1.2 0.028 14.7 1.2 2.3 1 1 1 2 2 2 0 Orf78 (ac78) Peptidase_M56 PF05569.11 ETO24267.1 - 0.081 12.1 1.3 0.11 11.7 0.8 1.4 1 1 0 1 1 1 0 BlaR1 peptidase M56 ETRAMP PF09716.10 ETO24267.1 - 0.2 11.7 3.6 0.27 11.3 2.8 1.6 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2371 PF10177.9 ETO24267.1 - 0.36 11.0 2.6 1.3 9.2 2.5 1.9 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) PRCC PF10253.9 ETO24267.1 - 2.9 8.6 11.4 17 6.1 11.4 2.2 1 1 0 1 1 1 0 Mitotic checkpoint regulator, MAD2B-interacting IF3_N PF05198.16 ETO24268.1 - 0.077 13.3 1.3 0.12 12.7 1.3 1.4 1 1 0 1 1 1 0 Translation initiation factor IF-3, N-terminal domain TMPIT PF07851.13 ETO24269.1 - 1.9e-58 198.3 18.3 2.3e-58 198.0 18.3 1.0 1 0 0 1 1 1 1 TMPIT-like protein CLZ PF16526.5 ETO24269.1 - 0.0016 18.8 7.3 0.0043 17.4 1.6 2.5 2 1 0 2 2 2 1 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF3584 PF12128.8 ETO24269.1 - 0.0021 15.7 2.2 0.0026 15.4 2.2 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) UPF0242 PF06785.11 ETO24269.1 - 0.0091 16.1 14.8 0.0091 16.1 14.8 1.9 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Laminin_II PF06009.12 ETO24269.1 - 0.0096 15.9 5.7 0.016 15.2 5.7 1.3 1 0 0 1 1 1 1 Laminin Domain II ACCA PF03255.14 ETO24269.1 - 0.02 14.7 5.0 0.036 13.9 5.0 1.4 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Phage_GP20 PF06810.11 ETO24269.1 - 0.027 14.3 6.1 0.11 12.3 6.1 1.9 1 1 0 1 1 1 0 Phage minor structural protein GP20 Death PF00531.22 ETO24269.1 - 0.03 14.5 0.8 0.063 13.5 0.8 1.5 1 0 0 1 1 1 0 Death domain BLOC1_2 PF10046.9 ETO24269.1 - 0.052 13.9 11.7 0.73 10.2 4.8 2.4 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Myb_DNA-bind_5 PF13873.6 ETO24269.1 - 0.083 13.0 5.5 0.16 12.0 2.7 2.6 1 1 1 2 2 2 0 Myb/SANT-like DNA-binding domain Med9 PF07544.13 ETO24269.1 - 0.085 13.0 6.3 0.18 11.9 4.3 2.3 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 DUF4795 PF16043.5 ETO24269.1 - 0.12 12.0 6.7 0.17 11.5 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4201 PF13870.6 ETO24269.1 - 0.13 12.0 11.7 0.2 11.4 11.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) End3 PF12761.7 ETO24269.1 - 0.15 12.2 10.8 0.21 11.7 10.8 1.2 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 FAM184 PF15665.5 ETO24269.1 - 0.15 11.8 11.4 0.4 10.4 11.4 1.6 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B DUF745 PF05335.13 ETO24269.1 - 0.16 11.7 3.6 0.24 11.1 3.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF745) MCC-bdg_PDZ PF10506.9 ETO24269.1 - 0.17 11.9 2.4 32 4.6 0.2 3.4 2 1 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF948 PF06103.11 ETO24269.1 - 0.19 12.0 5.2 0.16 12.3 2.7 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) TPR_MLP1_2 PF07926.12 ETO24269.1 - 0.22 11.6 13.0 0.36 10.9 13.0 1.3 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein Prefoldin PF02996.17 ETO24269.1 - 0.24 11.3 9.9 0.19 11.6 1.7 2.8 1 1 1 2 2 2 0 Prefoldin subunit FliD_C PF07195.12 ETO24269.1 - 0.28 10.6 8.9 0.039 13.4 4.2 1.8 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 C-terminus Rho_Binding PF08912.11 ETO24269.1 - 0.36 11.7 14.2 0.75 10.7 4.2 2.8 2 1 0 2 2 2 0 Rho Binding COG2 PF06148.11 ETO24269.1 - 0.37 10.9 5.5 0.73 9.9 4.9 1.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 Tup_N PF08581.10 ETO24269.1 - 0.58 10.5 11.5 0.23 11.8 2.7 2.7 1 1 1 2 2 2 0 Tup N-terminal Uso1_p115_C PF04871.13 ETO24269.1 - 0.67 10.3 10.4 1.6 9.1 10.4 1.6 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region MCPsignal PF00015.21 ETO24269.1 - 0.73 9.6 3.8 1.1 9.1 3.2 1.5 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Exonuc_VII_L PF02601.15 ETO24269.1 - 0.81 9.2 3.9 1 8.8 3.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med29 PF11568.8 ETO24269.1 - 0.82 9.9 7.2 1.3 9.2 7.2 1.3 1 0 0 1 1 1 0 Mediator complex subunit 29 Mod_r PF07200.13 ETO24269.1 - 0.93 9.6 11.7 2.4 8.2 11.7 1.7 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Fib_alpha PF08702.10 ETO24269.1 - 0.99 9.6 11.5 3 8.0 11.5 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Sec20 PF03908.13 ETO24269.1 - 1 9.3 5.7 0.99 9.4 3.4 2.4 2 1 0 2 2 1 0 Sec20 FapA PF03961.13 ETO24269.1 - 1.1 7.8 8.7 1.5 7.4 8.7 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DASH_Duo1 PF08651.10 ETO24269.1 - 1.2 8.9 9.4 4.6 7.1 1.3 2.7 2 1 1 3 3 2 0 DASH complex subunit Duo1 Seryl_tRNA_N PF02403.22 ETO24269.1 - 1.2 9.4 7.1 2.5 8.3 7.1 1.6 1 0 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Muted PF14942.6 ETO24269.1 - 2.1 8.7 13.0 3.6 7.9 13.0 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein CENP-H PF05837.12 ETO24269.1 - 3 8.3 11.0 13 6.2 11.0 1.9 1 1 0 1 1 1 0 Centromere protein H (CENP-H) NPV_P10 PF05531.12 ETO24269.1 - 3.4 8.2 4.9 16 6.0 4.8 2.2 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein RNA_pol_Rpb1_5 PF04998.17 ETO24269.1 - 4.3 6.7 6.0 7 6.0 6.0 1.2 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 5 CENP-Q PF13094.6 ETO24269.1 - 5 7.3 8.2 11 6.2 8.2 1.6 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit FlxA PF14282.6 ETO24269.1 - 5.3 7.1 12.5 24 5.0 12.5 2.0 1 1 0 1 1 1 0 FlxA-like protein DUF4709 PF15821.5 ETO24269.1 - 8.4 6.7 12.1 15 5.9 8.1 2.6 2 1 1 3 3 2 0 Domain of unknown function (DUF4709) Mst1_SARAH PF11629.8 ETO24269.1 - 8.7 6.5 8.8 2.6 8.2 0.4 3.2 3 0 0 3 3 2 0 C terminal SARAH domain of Mst1 MRPL52 PF18699.1 ETO24269.1 - 9.1 6.5 13.1 0.4 10.9 3.5 2.9 2 1 1 3 3 3 0 Mitoribosomal protein mL52 ABC_tran PF00005.27 ETO24272.1 - 3.7e-06 27.5 4.3 7.8e-06 26.5 0.0 2.3 2 0 0 2 2 2 1 ABC transporter O-antigen_lig PF13425.6 ETO24272.1 - 1.4 7.6 6.9 2.3 6.9 6.9 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein ABC_tran PF00005.27 ETO24273.1 - 7.1e-16 59.0 0.0 7.1e-16 59.0 0.0 3.0 2 1 1 3 3 3 1 ABC transporter SMC_N PF02463.19 ETO24273.1 - 1.3e-05 24.8 0.0 1.3e-05 24.8 0.0 2.1 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain Dynamin_N PF00350.23 ETO24273.1 - 0.002 18.2 0.0 0.002 18.2 0.0 3.6 3 2 0 3 3 3 1 Dynamin family MMR_HSR1 PF01926.23 ETO24273.1 - 0.0099 15.9 0.0 0.0099 15.9 0.0 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ETO24273.1 - 0.013 15.2 0.4 0.029 14.1 0.4 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO24273.1 - 0.013 16.0 0.1 0.013 16.0 0.1 3.8 2 2 1 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 ETO24273.1 - 0.015 15.2 0.4 0.015 15.2 0.4 2.3 1 1 0 2 2 2 0 RsgA GTPase SLM4 PF16818.5 ETO24273.1 - 6.6 6.7 9.1 21 5.1 6.9 2.7 2 1 0 2 2 2 0 Protein SLM4 Lipase_3 PF01764.25 ETO24274.1 - 1.2e-25 90.0 0.1 2.5e-25 89.0 0.1 1.5 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_5 PF12695.7 ETO24274.1 - 0.12 12.1 0.3 0.81 9.4 0.0 2.4 2 1 0 3 3 3 0 Alpha/beta hydrolase family Hormone_3 PF00159.18 ETO24274.1 - 6.6 6.9 6.5 5 7.3 0.4 3.1 3 0 0 3 3 3 0 Pancreatic hormone peptide Vps26 PF03643.15 ETO24275.1 - 1.1e-17 64.0 0.2 1.2e-17 63.8 0.2 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ETO24275.1 - 9.2e-06 25.8 0.3 3.8e-05 23.8 0.3 1.8 1 1 0 1 1 1 1 Arrestin (or S-antigen), N-terminal domain Saw1 PF11561.8 ETO24277.1 - 0.085 12.4 0.9 0.13 11.8 0.4 1.6 2 0 0 2 2 2 0 Single strand annealing-weakened 1 DUF563 PF04577.14 ETO24278.1 - 1.4e-15 58.0 0.6 3.4e-15 56.7 0.6 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF563) DUF4653 PF15546.6 ETO24279.1 - 0.00048 19.9 0.7 0.00073 19.2 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4653) B56 PF01603.20 ETO24279.1 - 0.011 14.7 1.6 0.016 14.2 1.6 1.1 1 0 0 1 1 1 0 Protein phosphatase 2A regulatory B subunit (B56 family) SOR PF07682.11 ETO24279.1 - 0.058 12.3 0.0 0.084 11.7 0.0 1.2 1 0 0 1 1 1 0 Sulphur oxygenase reductase Caps_synth PF05704.12 ETO24279.1 - 0.096 12.0 3.3 1.8 7.9 1.6 2.2 1 1 1 2 2 2 0 Capsular polysaccharide synthesis protein Esterase PF00756.20 ETO24280.1 - 0.1 12.2 2.2 1.9 8.1 0.1 2.0 2 0 0 2 2 2 0 Putative esterase AlbA_2 PF04326.14 ETO24281.1 - 2e-08 34.6 0.9 8.2e-08 32.6 0.1 2.4 2 0 0 2 2 2 1 Putative DNA-binding domain DUF3666 PF12408.8 ETO24281.1 - 0.12 11.6 0.2 0.23 10.7 0.2 1.5 1 0 0 1 1 1 0 Ribose-5-phosphate isomerase DUF4448 PF14610.6 ETO24281.1 - 2.2 8.0 0.0 2.2 8.0 0.0 3.0 3 1 1 4 4 4 0 Protein of unknown function (DUF4448) DUF2796 PF10986.8 ETO24283.1 - 0.015 15.2 0.2 0.015 15.2 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) Orf78 PF06024.12 ETO24283.1 - 0.4 11.0 2.8 0.6 10.4 2.8 1.3 1 0 0 1 1 1 0 Orf78 (ac78) LepB_N PF18640.1 ETO24284.1 - 0.028 14.1 0.3 0.061 12.9 0.3 1.5 1 0 0 1 1 1 0 LepB N-terminal domain DUF4196 PF13846.6 ETO24284.1 - 0.23 11.7 8.7 0.91 9.7 8.7 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4196) TamB PF04357.13 ETO24284.1 - 0.3 10.3 1.5 0.42 9.8 1.5 1.1 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex DUF3682 PF12446.8 ETO24284.1 - 0.47 10.9 7.3 1 9.8 7.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) PepSY_TM_like_2 PF16357.5 ETO24284.1 - 2 8.3 5.1 6.6 6.7 0.1 2.4 2 0 0 2 2 2 0 Putative PepSY_TM-like ETRAMP PF09716.10 ETO24286.1 - 6.9 6.8 10.3 15 5.7 2.0 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) EF-hand_7 PF13499.6 ETO24287.1 - 0.0075 16.7 0.9 0.062 13.8 0.2 3.1 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO24287.1 - 0.017 15.0 0.0 0.11 12.5 0.0 2.5 1 1 0 1 1 1 0 EF-hand domain EF-hand_8 PF13833.6 ETO24287.1 - 0.055 13.3 0.2 3 7.8 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair Rota_NSP4 PF01452.16 ETO24287.1 - 0.4 10.3 3.2 1.1 9.0 0.4 2.6 2 1 0 2 2 2 0 Rotavirus non structural protein DUF1018 PF06252.12 ETO24287.1 - 3.3 8.7 8.5 29 5.7 0.0 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1018) DUF2828 PF11443.8 ETO24288.1 - 0.011 13.9 10.1 0.012 13.8 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Tim54 PF11711.8 ETO24288.1 - 0.015 14.1 12.4 0.017 13.9 12.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 ETO24288.1 - 0.03 13.3 4.1 0.035 13.1 4.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TRAP_alpha PF03896.16 ETO24288.1 - 0.031 13.5 7.3 0.036 13.3 7.3 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 ETO24288.1 - 0.083 11.6 5.6 0.085 11.6 5.6 1.1 1 0 0 1 1 1 0 Presenilin RRN3 PF05327.11 ETO24288.1 - 0.13 10.8 10.4 0.15 10.6 10.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETO24288.1 - 0.16 10.2 11.4 0.18 10.1 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF1980 PF09323.10 ETO24288.1 - 0.2 11.5 2.6 0.29 11.0 2.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Atrophin-1 PF03154.15 ETO24288.1 - 0.24 9.6 26.5 0.34 9.1 26.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family RNA_pol_Rpc4 PF05132.14 ETO24288.1 - 0.28 11.6 12.2 0.49 10.8 12.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 POX PF07526.11 ETO24288.1 - 1.2 9.7 13.3 0.61 10.7 8.3 2.0 1 1 1 2 2 2 0 Associated with HOX Zip PF02535.22 ETO24288.1 - 1.3 8.1 5.0 1.5 8.0 5.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 ETO24288.1 - 1.9 7.8 19.3 3.2 7.1 19.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Roughex PF06020.11 ETO24288.1 - 3.5 6.6 12.9 4.8 6.2 12.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein PDCD2_C PF04194.13 ETO24288.1 - 4.1 7.4 18.1 3.7 7.6 17.2 1.3 1 1 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain Trypan_PARP PF05887.11 ETO24288.1 - 4.2 7.4 20.8 5.7 6.9 20.8 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) TMEM119 PF15724.5 ETO24288.1 - 6.4 6.8 10.6 9.8 6.2 10.6 1.2 1 0 0 1 1 1 0 TMEM119 family DDHD PF02862.17 ETO24289.1 - 0.16 12.1 4.2 0.21 11.7 4.2 1.3 1 0 0 1 1 1 0 DDHD domain DUF4775 PF16001.5 ETO24289.1 - 0.25 10.7 14.0 0.31 10.4 14.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4775) Suf PF05843.14 ETO24289.1 - 1.3 9.0 12.6 2.2 8.2 12.6 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) NOA36 PF06524.12 ETO24289.1 - 4.8 6.4 11.6 1.1 8.5 8.4 1.5 2 0 0 2 2 2 0 NOA36 protein GOLD_2 PF13897.6 ETO24289.1 - 5 7.6 5.7 10 6.6 5.7 1.6 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking RR_TM4-6 PF06459.12 ETO24289.1 - 5.4 6.8 13.1 7.8 6.2 13.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 SBDS_C PF09377.10 ETO24290.1 - 3.1e-30 104.6 0.3 6.1e-30 103.6 0.3 1.5 1 0 0 1 1 1 1 SBDS protein C-terminal domain SBDS PF01172.18 ETO24290.1 - 1.2e-17 63.8 1.7 1.4e-17 63.5 0.5 1.8 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein T3SchapCesA PF11439.8 ETO24290.1 - 0.2 11.8 2.3 0.4 10.9 0.9 2.1 2 0 0 2 2 2 0 Type III secretion system filament chaperone CesA dsDNA_bind PF01984.20 ETO24291.1 - 0.00092 19.5 19.6 0.17 12.1 19.6 2.1 1 1 0 1 1 1 1 Double-stranded DNA-binding domain Casc1_N PF15927.5 ETO24291.1 - 0.0031 17.2 5.1 0.0031 17.2 5.1 1.7 2 0 0 2 2 2 1 Cancer susceptibility candidate 1 N-terminus Mgr1 PF08602.10 ETO24291.1 - 0.041 12.7 4.0 0.048 12.5 4.0 1.0 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit 4HFCP_synth PF04476.13 ETO24291.1 - 0.12 12.1 4.2 0.13 12.0 4.2 1.0 1 0 0 1 1 1 0 4-HFC-P synthase Wax2_C PF12076.8 ETO24291.1 - 0.12 12.0 2.4 0.15 11.8 2.4 1.1 1 0 0 1 1 1 0 WAX2 C-terminal domain MMR1 PF08505.10 ETO24291.1 - 0.37 11.0 9.7 0.48 10.7 9.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Ribosomal_S13 PF00416.22 ETO24292.1 - 1.5e-26 93.3 0.0 2.3e-26 92.7 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S13/S18 Sec5 PF15469.6 ETO24293.1 - 2.1e-31 109.2 8.8 2.1e-31 109.2 8.8 2.8 3 0 0 3 3 3 1 Exocyst complex component Sec5 DUF4446 PF14584.6 ETO24293.1 - 0.046 13.7 0.2 0.046 13.7 0.2 3.4 2 1 2 4 4 4 0 Protein of unknown function (DUF4446) AI-2E_transport PF01594.16 ETO24293.1 - 0.11 11.6 0.7 0.35 10.0 0.7 1.8 1 0 0 1 1 1 0 AI-2E family transporter Peptidase_M60 PF13402.6 ETO24293.1 - 0.16 11.5 1.6 0.23 10.9 0.1 2.0 2 0 0 2 2 2 0 Peptidase M60, enhancin and enhancin-like CbiQ PF02361.16 ETO24294.1 - 0.099 12.2 3.0 0.4 10.3 0.8 2.2 2 0 0 2 2 2 0 Cobalt transport protein PPI_Ypi1 PF07491.11 ETO24294.1 - 2.5 8.0 6.2 3.7 7.4 0.0 3.4 4 0 0 4 4 4 0 Protein phosphatase inhibitor Red1 PF07964.11 ETO24296.1 - 0.75 8.0 30.3 0.88 7.7 30.3 1.0 1 0 0 1 1 1 0 Rec10 / Red1 RP-C_C PF11800.8 ETO24296.1 - 1.5 8.9 7.7 1.6 8.8 7.7 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Zip PF02535.22 ETO24296.1 - 3.5 6.8 8.1 3.6 6.7 8.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO24296.1 - 4.3 6.0 13.8 4 6.1 13.8 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO24296.1 - 6.5 4.9 17.5 6.6 4.9 17.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO24296.1 - 6.7 7.1 16.8 14 6.1 16.8 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Dsh_C PF12316.8 ETO24296.1 - 9.2 6.6 8.0 12 6.2 8.0 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal HMG_CoA_synt_N PF01154.17 ETO24297.1 - 1.1e-74 250.1 0.2 1.4e-50 171.6 0.1 2.3 2 0 0 2 2 2 2 Hydroxymethylglutaryl-coenzyme A synthase N terminal HMG_CoA_synt_C PF08540.10 ETO24297.1 - 9.2e-61 205.9 12.3 1.4e-30 106.9 2.2 3.4 3 0 0 3 3 3 3 Hydroxymethylglutaryl-coenzyme A synthase C terminal Guanylin PF02058.15 ETO24297.1 - 0.11 13.0 0.6 0.27 11.7 0.6 1.6 1 0 0 1 1 1 0 Guanylin precursor SAM_2 PF07647.17 ETO24298.1 - 2e-05 24.6 1.4 0.00028 21.0 0.2 2.5 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO24298.1 - 0.0011 19.4 0.2 0.0025 18.2 0.2 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cep57_CLD_2 PF14197.6 ETO24298.1 - 0.0017 18.4 6.2 0.0017 18.4 6.2 4.3 3 1 0 4 4 4 1 Centrosome localisation domain of PPC89 TPR_MLP1_2 PF07926.12 ETO24298.1 - 0.0023 18.0 7.6 0.0023 18.0 7.6 3.2 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO24298.1 - 0.0035 16.7 9.0 0.0035 16.7 9.0 2.1 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) DUF2046 PF09755.9 ETO24298.1 - 0.0063 15.8 4.9 0.0063 15.8 4.9 3.5 2 1 1 3 3 3 2 Uncharacterized conserved protein H4 (DUF2046) GIT_CC PF16559.5 ETO24298.1 - 0.008 16.0 8.3 0.008 16.0 8.3 3.2 2 1 1 3 3 3 1 GIT coiled-coil Rho guanine nucleotide exchange factor CLZ PF16526.5 ETO24298.1 - 0.021 15.2 6.9 0.021 15.2 6.9 3.3 3 1 1 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels XhlA PF10779.9 ETO24298.1 - 0.026 14.7 4.3 0.026 14.7 4.3 3.3 3 1 1 4 4 3 0 Haemolysin XhlA DUF641 PF04859.12 ETO24298.1 - 0.04 14.3 1.5 0.04 14.3 1.5 2.6 2 1 0 2 2 2 0 Plant protein of unknown function (DUF641) DnaA_N PF11638.8 ETO24298.1 - 0.052 13.3 0.1 0.14 12.0 0.1 1.7 1 0 0 1 1 1 0 DnaA N-terminal domain ATG16 PF08614.11 ETO24298.1 - 0.053 13.8 32.0 0.44 10.7 18.6 2.4 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) HMMR_N PF15905.5 ETO24298.1 - 0.058 12.9 26.3 0.53 9.7 12.2 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Golgin_A5 PF09787.9 ETO24298.1 - 0.16 11.4 28.1 1.1 8.7 4.4 2.2 2 0 0 2 2 2 0 Golgin subfamily A member 5 Fez1 PF06818.15 ETO24298.1 - 0.17 12.3 20.9 0.22 12.0 11.3 2.2 2 0 0 2 2 2 0 Fez1 Tup_N PF08581.10 ETO24298.1 - 0.17 12.2 26.7 0.072 13.4 5.7 3.2 3 1 1 4 4 3 0 Tup N-terminal Tropomyosin_1 PF12718.7 ETO24298.1 - 0.28 11.4 30.5 0.025 14.7 18.2 2.9 2 1 1 3 3 3 0 Tropomyosin like Spc7 PF08317.11 ETO24298.1 - 0.3 9.9 30.5 0.053 12.4 16.7 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein KASH_CCD PF14662.6 ETO24298.1 - 0.35 10.7 27.1 0.022 14.6 14.8 2.5 2 1 0 2 2 2 0 Coiled-coil region of CCDC155 or KASH Rootletin PF15035.6 ETO24298.1 - 0.35 10.9 23.1 0.2 11.7 12.8 2.3 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion DUF489 PF04356.12 ETO24298.1 - 0.36 10.8 10.9 0.23 11.5 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF489) Cep57_CLD PF14073.6 ETO24298.1 - 0.48 10.4 27.3 0.12 12.4 15.1 2.3 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Syja_N PF02383.18 ETO24298.1 - 0.59 9.4 3.7 0.26 10.6 0.2 1.9 2 0 0 2 2 2 0 SacI homology domain DUF2935 PF11155.8 ETO24298.1 - 0.61 10.4 8.0 1.7 9.0 0.2 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF2935) UPF0449 PF15136.6 ETO24298.1 - 0.7 10.4 18.6 0.64 10.5 0.6 3.3 2 2 0 2 2 2 0 Uncharacterised protein family UPF0449 Atg14 PF10186.9 ETO24298.1 - 0.78 8.8 22.9 0.018 14.1 10.0 2.1 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nup54 PF13874.6 ETO24298.1 - 0.78 9.8 21.6 0.1 12.7 10.1 2.7 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 CHDCT2 PF08074.11 ETO24298.1 - 0.83 9.8 12.7 2.9 8.0 4.8 2.3 2 0 0 2 2 2 0 CHDCT2 (NUC038) domain APC_N_CC PF16689.5 ETO24298.1 - 0.86 9.7 10.6 0.29 11.2 3.6 3.1 3 0 0 3 3 2 0 Coiled-coil N-terminus of APC, dimerisation domain Jnk-SapK_ap_N PF09744.9 ETO24298.1 - 0.9 9.8 26.3 0.43 10.8 14.3 2.4 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF724 PF05266.14 ETO24298.1 - 0.99 9.2 29.0 0.19 11.6 9.5 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF724) HAUS-augmin3 PF14932.6 ETO24298.1 - 1 8.9 26.6 2.2 7.8 15.8 2.8 2 1 0 2 2 2 0 HAUS augmin-like complex subunit 3 UPF0242 PF06785.11 ETO24298.1 - 1 9.4 33.4 17 5.4 18.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 ETO24298.1 - 1.1 8.8 19.0 3.1 7.3 2.3 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit CENP-F_leu_zip PF10473.9 ETO24298.1 - 1.2 9.1 31.1 0.2 11.7 15.8 3.5 2 2 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 CENP-H PF05837.12 ETO24298.1 - 1.7 9.1 28.4 0.55 10.7 10.7 2.9 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Baculo_PEP_C PF04513.12 ETO24298.1 - 2 8.4 16.8 0.59 10.2 9.2 2.4 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF4164 PF13747.6 ETO24298.1 - 2.3 8.5 20.0 0.18 12.1 10.3 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4164) WXG100 PF06013.12 ETO24298.1 - 2.5 8.4 12.3 0.23 11.7 6.4 2.3 2 0 0 2 2 1 0 Proteins of 100 residues with WXG Med9 PF07544.13 ETO24298.1 - 2.8 8.1 16.5 4.6 7.4 3.8 2.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Fmp27_WPPW PF10359.9 ETO24298.1 - 3.2 6.5 19.0 0.12 11.1 10.0 2.0 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain PRKG1_interact PF15898.5 ETO24298.1 - 3.2 8.7 28.4 1.9 9.4 12.2 2.7 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain T3SSipB PF16535.5 ETO24298.1 - 3.4 8.1 25.0 2.8 8.4 18.3 2.8 2 1 0 2 2 2 0 Type III cell invasion protein SipB FapA PF03961.13 ETO24298.1 - 3.6 6.1 22.9 0.83 8.2 2.9 2.6 2 1 1 3 3 3 0 Flagellar Assembly Protein A AATF-Che1 PF13339.6 ETO24298.1 - 4.4 8.0 22.1 3 8.5 10.6 2.8 2 1 1 3 3 3 0 Apoptosis antagonizing transcription factor DUF3584 PF12128.8 ETO24298.1 - 4.8 4.6 26.6 0.14 9.7 15.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Ax_dynein_light PF10211.9 ETO24298.1 - 6.3 6.7 25.2 5 7.0 6.2 3.1 2 1 1 3 3 3 0 Axonemal dynein light chain DUF1664 PF07889.12 ETO24298.1 - 6.5 6.8 17.6 0.37 10.9 5.4 2.8 3 0 0 3 3 2 0 Protein of unknown function (DUF1664) APG6_N PF17675.1 ETO24298.1 - 6.7 7.2 34.5 3.5 8.2 1.7 3.2 2 1 1 3 3 3 0 Apg6 coiled-coil region EMP24_GP25L PF01105.24 ETO24298.1 - 8.3 6.3 11.7 36 4.2 0.1 2.6 2 2 0 2 2 2 0 emp24/gp25L/p24 family/GOLD ABC_trans_N PF14510.6 ETO24298.1 - 8.5 7.1 8.5 2.2 9.0 4.3 2.3 2 1 0 2 2 1 0 ABC-transporter N-terminal Sec2p PF06428.11 ETO24298.1 - 8.7 6.4 31.0 14 5.8 14.8 3.5 2 1 0 2 2 2 0 GDP/GTP exchange factor Sec2p HIP1_clath_bdg PF16515.5 ETO24298.1 - 8.9 7.0 26.4 1 10.0 12.9 2.8 2 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF4201 PF13870.6 ETO24298.1 - 9.1 6.0 26.3 0.69 9.6 11.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) Uso1_p115_C PF04871.13 ETO24298.1 - 9.3 6.6 35.6 1 9.8 18.8 3.2 2 1 1 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region Kelch_6 PF13964.6 ETO24301.1 - 3.2e-08 33.6 2.0 0.012 15.9 0.1 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO24301.1 - 1e-05 25.0 4.5 0.0051 16.4 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO24301.1 - 0.016 15.2 2.3 2 8.5 0.1 3.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO24301.1 - 0.038 14.0 6.0 2.7 8.1 0.1 3.8 3 0 0 3 3 3 0 Kelch motif Apis_Csd PF11671.8 ETO24302.1 - 0.9 9.5 9.9 1.7 8.6 9.9 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein DAGAT PF03982.13 ETO24303.1 - 6.6e-22 77.8 0.0 1.1e-21 77.1 0.0 1.3 1 0 0 1 1 1 1 Diacylglycerol acyltransferase HSP70 PF00012.20 ETO24304.1 - 2.3e-33 115.3 11.9 2.7e-33 115.1 11.9 1.0 1 0 0 1 1 1 1 Hsp70 protein LMP PF04778.12 ETO24304.1 - 0.0021 18.0 9.0 0.0041 17.1 8.9 1.9 1 1 0 1 1 1 1 LMP repeated region Bactofilin PF04519.13 ETO24304.1 - 0.046 14.0 0.5 0.089 13.1 0.3 1.6 1 1 0 1 1 1 0 Polymer-forming cytoskeletal Spc7 PF08317.11 ETO24304.1 - 0.062 12.2 10.2 0.074 11.9 10.2 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF4810 PF16068.5 ETO24304.1 - 1.6 9.3 5.5 0.7 10.5 1.4 2.3 1 1 2 3 3 3 0 Domain of unknown function (DUF4810) Pex14_N PF04695.13 ETO24304.1 - 5.1 7.7 8.9 32 5.1 8.9 1.9 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ATP-synt_S1 PF05827.12 ETO24305.1 - 0.084 12.7 2.3 25 4.7 0.1 3.2 2 1 1 3 3 3 0 Vacuolar ATP synthase subunit S1 (ATP6S1) Syja_N PF02383.18 ETO24307.1 - 1.6e-61 208.4 10.9 1.9e-61 208.1 2.9 3.2 2 1 0 2 2 2 1 SacI homology domain SPT6_acidic PF14632.6 ETO24307.1 - 1.4 9.6 18.6 0.76 10.4 1.5 2.9 2 0 0 2 2 2 0 Acidic N-terminal SPT6 Roughex PF06020.11 ETO24307.1 - 1.8 7.6 7.0 3.5 6.6 7.0 1.4 1 0 0 1 1 1 0 Drosophila roughex protein DUF702 PF05142.12 ETO24307.1 - 4.4 7.8 6.5 4.3 7.8 3.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF702) SBP_bac_8 PF13416.6 ETO24309.1 - 0.004 17.0 0.4 0.004 17.0 0.4 1.2 1 0 0 1 1 1 1 Bacterial extracellular solute-binding protein Cofilin_ADF PF00241.20 ETO24310.1 - 0.00041 20.1 0.1 0.00057 19.7 0.1 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein DUF2649 PF10854.8 ETO24310.1 - 0.65 10.4 4.1 3.9 7.8 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2649) DUF4255 PF14065.6 ETO24312.1 - 0.084 12.5 0.1 0.16 11.7 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4255) Dicty_spore_N PF04562.12 ETO24312.1 - 0.79 10.5 7.0 0.58 10.9 2.6 2.4 2 0 0 2 2 2 0 Dictyostelium spore coat protein, N terminus DUF812 PF05667.11 ETO24313.1 - 2.8e-151 505.4 50.7 2.8e-151 505.4 50.7 2.5 1 1 1 2 2 2 1 Protein of unknown function (DUF812) Spc7 PF08317.11 ETO24313.1 - 0.00082 18.4 75.5 0.007 15.3 28.2 4.2 1 1 3 4 4 4 3 Spc7 kinetochore protein Lectin_N PF03954.14 ETO24313.1 - 0.0055 16.5 6.3 0.0055 16.5 6.3 4.2 2 1 1 4 4 4 1 Hepatic lectin, N-terminal domain CENP-F_leu_zip PF10473.9 ETO24313.1 - 0.016 15.2 11.2 0.016 15.2 11.2 4.0 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Pox_A_type_inc PF04508.12 ETO24313.1 - 0.02 14.7 1.2 0.02 14.7 1.2 5.5 5 0 0 5 5 5 0 Viral A-type inclusion protein repeat Allexi_40kDa PF05549.11 ETO24313.1 - 0.9 9.0 34.4 0.12 11.8 5.3 3.9 1 1 4 5 5 5 0 Allexivirus 40kDa protein Cluap1 PF10234.9 ETO24313.1 - 0.94 8.8 0.0 0.94 8.8 0.0 5.1 2 1 3 5 5 5 0 Clusterin-associated protein-1 T2SSF PF00482.23 ETO24313.1 - 4.5 7.3 6.2 14 5.6 0.3 3.5 4 0 0 4 4 4 0 Type II secretion system (T2SS), protein F Fib_alpha PF08702.10 ETO24313.1 - 8.4 6.6 55.1 1.5 9.0 18.0 4.8 2 1 2 5 5 5 0 Fibrinogen alpha/beta chain family AF-4 PF05110.13 ETO24314.1 - 1.2 7.2 32.0 1.4 6.9 32.0 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein MTBP_C PF14920.6 ETO24315.1 - 0.026 14.3 4.5 0.031 14.0 4.5 1.1 1 0 0 1 1 1 0 MDM2-binding DAAD PF18752.1 ETO24315.1 - 0.11 12.3 6.8 0.14 11.9 6.8 1.1 1 0 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase Ndc1_Nup PF09531.10 ETO24315.1 - 0.69 8.5 10.0 0.83 8.3 10.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF1387 PF07139.11 ETO24315.1 - 0.88 9.2 13.4 1.2 8.9 13.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) VWA PF00092.28 ETO24317.1 - 1.1e-08 35.5 0.0 2e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO24317.1 - 2.4e-08 34.6 0.0 4.7e-08 33.6 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO24317.1 - 7.9e-08 32.4 0.0 1.3e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ETO24317.1 - 0.011 15.8 0.0 0.032 14.4 0.0 1.7 1 1 0 1 1 1 0 vWA found in TerF C terminus Copine PF07002.16 ETO24317.1 - 0.044 13.2 0.0 0.11 12.0 0.0 1.6 2 0 0 2 2 2 0 Copine TPR_1 PF00515.28 ETO24318.1 - 3.3e-37 124.8 32.9 9.4e-07 28.4 0.4 11.9 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24318.1 - 3.7e-34 114.1 19.4 3.4e-05 23.6 0.1 10.7 12 0 0 12 12 11 7 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24318.1 - 1e-25 89.8 9.4 0.00067 19.9 0.6 8.7 7 3 0 7 7 7 5 Tetratricopeptide repeat TPR_19 PF14559.6 ETO24318.1 - 1.2e-23 83.4 8.2 9.8e-07 29.2 0.0 7.0 6 1 0 7 7 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24318.1 - 1.6e-23 81.7 8.4 0.034 14.8 0.0 10.5 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24318.1 - 3.1e-23 80.1 2.9 0.0011 18.9 0.0 9.5 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24318.1 - 6.7e-21 72.7 31.5 0.015 15.4 0.2 11.8 12 0 0 12 12 12 7 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24318.1 - 3.6e-16 58.6 16.3 4.9e-05 22.9 0.2 8.7 7 1 2 9 9 9 4 TPR repeat TPR_14 PF13428.6 ETO24318.1 - 1.2e-15 56.9 0.0 0.19 12.7 0.0 8.8 7 2 2 9 9 9 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO24318.1 - 9.7e-14 51.4 26.2 2.5e-06 27.6 3.5 6.6 6 2 0 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO24318.1 - 3.3e-12 46.8 0.0 0.019 15.6 0.0 6.6 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24318.1 - 1.5e-06 28.2 21.4 0.59 10.6 0.1 9.3 11 1 0 11 11 8 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO24318.1 - 1.5e-05 24.6 1.0 0.00029 20.3 0.1 2.9 2 1 0 2 2 2 1 MalT-like TPR region TPR_10 PF13374.6 ETO24318.1 - 6.4e-05 22.7 3.8 0.011 15.6 0.0 5.3 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO24318.1 - 0.00017 21.6 0.0 3.7 7.7 0.0 5.2 5 1 1 6 6 6 1 Tetratricopeptide repeat RPN7 PF10602.9 ETO24318.1 - 0.00025 20.8 5.2 0.063 13.0 0.4 4.1 4 1 0 4 4 4 1 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 ETO24318.1 - 0.00061 19.8 3.2 14 5.9 0.0 4.8 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat Foie-gras_1 PF11817.8 ETO24318.1 - 0.012 15.2 4.2 2.8 7.5 0.2 4.1 4 0 0 4 4 4 0 Foie gras liver health family 1 MIT PF04212.18 ETO24318.1 - 0.024 14.7 22.9 0.34 11.0 0.1 8.2 10 1 1 11 11 10 0 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 ETO24318.1 - 0.16 11.6 7.6 0.3 10.8 0.6 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat-like domain HAUS6_N PF14661.6 ETO24318.1 - 1.5 8.3 7.3 0.71 9.4 1.8 2.6 2 0 0 2 2 2 0 HAUS augmin-like complex subunit 6 N-terminus PPR_2 PF13041.6 ETO24318.1 - 6.3 7.1 11.9 60 3.9 0.0 5.4 6 0 0 6 6 5 0 PPR repeat family PPR PF01535.20 ETO24318.1 - 8.6 6.9 13.9 64 4.1 0.0 6.4 8 0 0 8 8 5 0 PPR repeat Rhodanese PF00581.20 ETO24319.1 - 3.9e-07 30.5 0.0 7.7e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Rhodanese-like domain LRR_8 PF13855.6 ETO24320.1 - 3.1e-14 52.5 52.0 0.0036 17.0 0.2 9.4 7 3 3 11 11 11 7 Leucine rich repeat LRR_4 PF12799.7 ETO24320.1 - 7.9e-12 45.2 45.7 0.11 12.9 0.0 10.7 7 2 7 14 14 14 9 Leucine Rich repeats (2 copies) LRRNT_2 PF08263.12 ETO24320.1 - 0.00091 19.5 1.9 0.00091 19.5 1.9 2.3 2 0 0 2 2 2 1 Leucine rich repeat N-terminal domain DUF3338 PF11819.8 ETO24320.1 - 0.026 14.5 0.8 14 5.6 0.1 4.0 2 2 2 4 4 4 0 Domain of unknown function (DUF3338) FNIP PF05725.12 ETO24320.1 - 0.16 12.2 1.8 4.8 7.4 0.0 4.3 3 2 0 3 3 3 0 FNIP Repeat OTU PF02338.19 ETO24321.1 - 0.052 14.0 1.0 0.094 13.2 1.0 1.4 1 0 0 1 1 1 0 OTU-like cysteine protease DUF2115 PF09888.9 ETO24321.1 - 0.1 13.1 1.8 0.15 12.6 1.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) DUF4413 PF14372.6 ETO24321.1 - 1.1 9.6 5.2 6.3 7.2 1.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4413) NDT80_PhoG PF05224.12 ETO24322.1 - 0.031 14.5 2.8 0.047 13.9 2.8 1.2 1 0 0 1 1 1 0 NDT80 / PhoG like DNA-binding family Herpes_UL25 PF01499.16 ETO24322.1 - 0.12 10.8 5.2 0.16 10.5 5.2 1.1 1 0 0 1 1 1 0 Herpesvirus UL25 family Atg14 PF10186.9 ETO24322.1 - 1.4 7.9 11.2 2.1 7.3 11.2 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 UPF0242 PF06785.11 ETO24322.1 - 2.3 8.3 12.4 3.4 7.7 12.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 ETO24322.1 - 2.4 7.4 9.3 3.3 7.0 9.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PEP-utilisers_N PF05524.13 ETO24322.1 - 2.6 8.2 5.1 6.8 6.9 5.0 1.8 1 1 0 1 1 1 0 PEP-utilising enzyme, N-terminal TMPIT PF07851.13 ETO24322.1 - 2.9 7.1 10.2 4.1 6.6 10.2 1.1 1 0 0 1 1 1 0 TMPIT-like protein Presenilin PF01080.17 ETO24322.1 - 4.8 5.8 5.4 6.1 5.5 5.4 1.1 1 0 0 1 1 1 0 Presenilin DUF16 PF01519.16 ETO24322.1 - 5.3 7.6 15.6 1.5e+02 3.0 15.6 2.2 1 1 0 1 1 1 0 Protein of unknown function DUF16 Tropomyosin_1 PF12718.7 ETO24322.1 - 8.3 6.6 21.3 43 4.2 20.4 1.9 1 1 1 2 2 2 0 Tropomyosin like DUF3512 PF12024.8 ETO24322.1 - 8.9 5.7 9.5 0.79 9.2 0.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3512) RhoGAP PF00620.27 ETO24323.1 - 1.2e-15 57.6 0.0 2.4e-15 56.7 0.0 1.5 1 0 0 1 1 1 1 RhoGAP domain PBD PF00786.28 ETO24323.1 - 6e-05 23.3 0.0 0.00016 21.9 0.0 1.9 1 0 0 1 1 1 1 P21-Rho-binding domain BUD22 PF09073.10 ETO24324.1 - 0.16 11.3 39.5 0.25 10.6 39.5 1.2 1 0 0 1 1 1 0 BUD22 Macoilin PF09726.9 ETO24324.1 - 0.86 8.1 17.3 1.2 7.7 17.3 1.1 1 0 0 1 1 1 0 Macoilin family Borrelia_P83 PF05262.11 ETO24324.1 - 1.5 7.2 25.0 2.1 6.7 25.0 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein 7TMR-DISM_7TM PF07695.11 ETO24324.1 - 1.6 8.6 11.4 4.8 7.0 2.3 2.2 2 0 0 2 2 2 0 7TM diverse intracellular signalling DUF2208 PF09973.9 ETO24325.1 - 0.067 12.8 4.9 0.097 12.3 4.9 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2208) Ctr PF04145.15 ETO24326.1 - 1.5e-22 80.8 0.1 1.5e-22 80.8 0.1 2.0 2 0 0 2 2 2 1 Ctr copper transporter family SAM_2 PF07647.17 ETO24329.1 - 4.5e-11 42.7 0.6 2.7e-09 37.0 0.2 2.7 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO24329.1 - 8.2e-09 35.8 0.3 1.1e-07 32.2 0.1 2.5 2 1 0 2 2 2 1 SAM domain (Sterile alpha motif) Menin PF05053.13 ETO24329.1 - 0.67 8.2 8.0 0.95 7.7 8.0 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO24329.1 - 3.9 6.6 4.4 4.7 6.3 4.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO24329.1 - 5.7 5.6 6.1 7.8 5.2 6.1 1.2 1 0 0 1 1 1 0 Presenilin TMEM214 PF10151.9 ETO24329.1 - 7.1 4.9 12.8 10 4.5 12.8 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator ALMT PF11744.8 ETO24329.1 - 8.7 5.0 7.5 13 4.5 7.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 ETO24330.1 - 2.8e-11 43.8 9.2 8.1e-06 26.5 0.0 5.5 5 1 1 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24330.1 - 0.0018 18.5 0.1 11 6.5 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24330.1 - 0.04 12.9 0.1 4.7 6.1 0.0 2.3 2 0 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein bZIP_1 PF00170.21 ETO24330.1 - 1.1 9.4 3.9 4.1 7.6 1.3 2.5 1 1 1 2 2 2 0 bZIP transcription factor SNARE PF05739.19 ETO24332.1 - 1.8e-17 63.1 3.4 1.8e-17 63.1 3.4 2.1 2 0 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ETO24332.1 - 0.023 14.4 17.0 0.085 12.5 5.9 2.9 1 1 1 2 2 2 0 Syntaxin Syntaxin-6_N PF09177.11 ETO24332.1 - 0.17 12.5 8.0 0.081 13.5 1.4 3.4 3 1 0 3 3 3 0 Syntaxin 6, N-terminal BatA PF07584.11 ETO24332.1 - 0.29 11.5 1.1 1.8 8.9 0.1 2.7 2 0 0 2 2 2 0 Aerotolerance regulator N-terminal DUF4083 PF13314.6 ETO24332.1 - 3.1 7.8 7.1 13 5.8 7.1 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Tfb2 PF03849.14 ETO24333.1 - 1.4e-104 349.9 5.9 1.7e-104 349.6 5.9 1.1 1 0 0 1 1 1 1 Transcription factor Tfb2 Tfb2_C PF18307.1 ETO24333.1 - 5.2e-07 30.0 0.0 1.2e-06 28.8 0.0 1.7 1 0 0 1 1 1 1 Transcription factor Tfb2 (p52) C-terminal domain Helicase_C_3 PF13625.6 ETO24333.1 - 0.00097 19.3 0.0 0.0034 17.5 0.0 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Beta_lactamase3 PF17030.5 ETO24334.1 - 0.48 9.6 8.2 0.93 8.7 8.2 1.4 1 0 0 1 1 1 0 Putative beta-lactamase-like family FAM104 PF15434.6 ETO24334.1 - 1.2 9.7 4.3 0.68 10.5 1.5 1.9 2 0 0 2 2 2 0 Family 104 EphA2_TM PF14575.6 ETO24335.1 - 0.03 15.2 0.7 1.3 10.0 0.0 2.5 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Gag_p17 PF00540.18 ETO24335.1 - 0.074 13.0 2.6 0.096 12.7 0.9 2.0 2 0 0 2 2 2 0 gag gene protein p17 (matrix protein) LacI PF00356.21 ETO24336.1 - 0.26 11.1 0.1 0.45 10.3 0.1 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, lacI family DUF3099 PF11298.8 ETO24337.1 - 0.96 9.6 4.0 1.1 9.5 0.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3099) PIP5K PF01504.18 ETO24338.1 - 1.8e-25 89.7 0.1 4.8e-25 88.3 0.0 1.8 2 1 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF4564 PF15169.6 ETO24338.1 - 0.0027 17.5 0.1 0.0059 16.4 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4564) RRM_1 PF00076.22 ETO24341.1 - 0.00012 21.9 0.0 0.00023 20.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Phage_int_SAM_3 PF14659.6 ETO24342.1 - 0.012 15.9 0.9 0.68 10.2 0.1 3.0 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Tmemb_9 PF05434.11 ETO24342.1 - 0.012 15.5 0.5 0.012 15.5 0.5 5.7 5 2 0 5 5 5 0 TMEM9 EphA2_TM PF14575.6 ETO24342.1 - 0.043 14.7 0.1 0.043 14.7 0.1 4.8 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Shisa PF13908.6 ETO24342.1 - 0.34 11.1 0.0 0.34 11.1 0.0 6.4 3 1 2 6 6 6 0 Wnt and FGF inhibitory regulator DNA_pol_lambd_f PF10391.9 ETO24344.1 - 0.082 12.7 0.1 0.12 12.2 0.1 1.2 1 0 0 1 1 1 0 Fingers domain of DNA polymerase lambda EF-hand_6 PF13405.6 ETO24345.1 - 0.0001 22.0 0.8 0.025 14.5 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain EF-hand_1 PF00036.32 ETO24345.1 - 0.0003 20.1 1.0 0.0017 17.7 0.0 2.8 3 0 0 3 3 3 1 EF hand EF-hand_5 PF13202.6 ETO24345.1 - 0.0055 16.2 0.1 0.0055 16.2 0.1 1.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO24345.1 - 0.022 15.2 3.6 0.25 11.8 0.1 2.6 1 1 0 2 2 2 0 EF-hand domain pair HEPN_STY4199 PF18729.1 ETO24345.1 - 0.043 13.0 0.0 0.081 12.1 0.0 1.4 1 0 0 1 1 1 0 STY4199-like HEPN EF-hand_8 PF13833.6 ETO24345.1 - 0.21 11.4 0.8 1 9.2 0.0 2.5 4 0 0 4 4 4 0 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO24345.1 - 0.36 11.2 3.0 4.6 7.6 0.0 2.7 2 1 1 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region Acyltransferase PF01553.21 ETO24346.1 - 1.9e-09 37.3 0.0 3.4e-09 36.4 0.0 1.4 1 0 0 1 1 1 1 Acyltransferase Tup_N PF08581.10 ETO24348.1 - 0.0085 16.4 7.9 0.0085 16.4 7.9 3.7 1 1 2 4 4 4 1 Tup N-terminal BLOC1_2 PF10046.9 ETO24348.1 - 0.017 15.4 4.1 0.017 15.4 4.1 4.2 1 1 3 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HMMR_N PF15905.5 ETO24348.1 - 0.073 12.5 45.8 0.37 10.2 25.5 2.1 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal HrpB7 PF09486.10 ETO24348.1 - 0.073 13.5 8.8 0.23 11.8 0.4 3.0 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) HAP1_N PF04849.13 ETO24348.1 - 0.19 10.9 38.8 7.3 5.7 38.9 2.1 1 1 0 1 1 1 0 HAP1 N-terminal conserved region DUF3450 PF11932.8 ETO24348.1 - 0.2 10.9 38.9 0.86 8.9 10.2 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) FPP PF05911.11 ETO24348.1 - 0.21 9.8 39.5 0.27 9.4 39.0 1.4 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil CC2-LZ PF16516.5 ETO24348.1 - 0.38 11.2 35.5 0.16 12.4 4.0 3.9 1 1 2 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator KASH_CCD PF14662.6 ETO24348.1 - 0.54 10.1 45.9 1.2 8.9 19.8 2.1 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH CENP-Q PF13094.6 ETO24348.1 - 0.62 10.2 29.7 0.56 10.4 13.5 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ATG16 PF08614.11 ETO24348.1 - 1.7 8.9 38.8 0.088 13.0 7.3 3.0 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ETO24348.1 - 1.9 8.9 35.0 0.068 13.6 12.9 2.2 1 1 1 2 2 2 0 Fez1 Tropomyosin_1 PF12718.7 ETO24348.1 - 2.4 8.3 47.0 0.65 10.1 5.1 4.2 1 1 3 4 4 4 0 Tropomyosin like CENP-F_leu_zip PF10473.9 ETO24348.1 - 6.6 6.8 39.2 2.5 8.1 18.6 3.6 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 ETO24348.1 - 7.3 6.9 34.4 0.14 12.4 4.7 3.7 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Fib_alpha PF08702.10 ETO24348.1 - 7.4 6.8 40.0 0.18 12.0 16.0 2.7 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family CEP63 PF17045.5 ETO24348.1 - 7.5 6.4 40.2 13 5.6 11.7 2.6 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa ADIP PF11559.8 ETO24348.1 - 9.6 6.3 45.5 0.54 10.3 21.8 3.8 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding Saw1 PF11561.8 ETO24350.1 - 0.13 11.8 0.2 0.17 11.4 0.2 1.1 1 0 0 1 1 1 0 Single strand annealing-weakened 1 DUF3439 PF11921.8 ETO24351.1 - 6.6 6.7 9.8 23 5.0 9.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SAM_PNT PF02198.16 ETO24352.1 - 0.0014 18.6 0.2 0.0051 16.8 0.1 2.0 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 ETO24352.1 - 0.096 12.8 1.5 0.2 11.8 0.4 2.3 2 1 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF4704 PF15787.5 ETO24353.1 - 2.9e-08 33.3 5.0 0.0041 16.4 4.3 3.0 2 2 0 2 2 2 2 Domain of unknown function (DUF4704) Laminin_G_3 PF13385.6 ETO24353.1 - 0.00015 22.0 0.0 0.00037 20.7 0.0 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Complex1_LYR PF05347.15 ETO24353.1 - 0.51 10.4 2.0 8.1 6.6 0.3 2.6 2 0 0 2 2 2 0 Complex 1 protein (LYR family) Beach PF02138.18 ETO24354.1 - 9.4e-112 372.9 3.4 1.5e-110 368.9 0.2 2.9 2 1 0 2 2 2 1 Beige/BEACH domain FYVE PF01363.21 ETO24354.1 - 1.2e-18 67.0 11.8 3.1e-18 65.7 11.8 1.8 1 0 0 1 1 1 1 FYVE zinc finger WD40 PF00400.32 ETO24354.1 - 3.8e-10 40.2 18.9 8.7e-07 29.6 0.4 5.8 4 1 0 4 4 4 2 WD domain, G-beta repeat PH_BEACH PF14844.6 ETO24354.1 - 1.4e-09 37.9 0.2 1.4e-09 37.9 0.2 2.5 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH ANAPC4_WD40 PF12894.7 ETO24354.1 - 0.014 15.7 1.1 0.2 12.0 0.1 3.3 3 1 1 4 4 4 0 Anaphase-promoting complex subunit 4 WD40 domain IBR PF01485.21 ETO24354.1 - 0.02 15.1 10.2 0.059 13.6 10.2 1.8 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain BRCT_3 PF18428.1 ETO24356.1 - 2.1e-05 24.5 0.1 5.4e-05 23.2 0.1 1.7 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain RTT107_BRCT_6 PF16771.5 ETO24356.1 - 0.0033 17.6 0.4 0.0033 17.6 0.4 2.2 2 0 0 2 2 2 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_2 PF16589.5 ETO24356.1 - 0.01 16.3 0.5 0.082 13.3 0.2 2.3 2 0 0 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain PA26 PF04636.13 ETO24357.1 - 0.058 12.3 5.6 0.063 12.2 5.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 ETO24357.1 - 6.6 5.4 7.9 7.9 5.1 7.9 1.2 1 0 0 1 1 1 0 Presenilin O-antigen_lig PF13425.6 ETO24357.1 - 8.1 5.1 7.6 9.2 4.9 7.6 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein WD40 PF00400.32 ETO24358.1 - 5.7e-62 204.2 20.8 1.6e-09 38.2 0.1 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24358.1 - 3.4e-14 52.9 0.9 0.0055 17.0 0.0 7.7 3 1 5 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24358.1 - 1e-07 31.2 0.3 0.18 10.8 0.0 5.8 2 2 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO24358.1 - 0.0056 15.3 0.1 0.14 10.7 0.0 2.5 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO24358.1 - 0.04 13.3 5.6 1.4 8.1 0.0 3.4 5 0 0 5 5 5 0 WD40-like domain WW PF00397.26 ETO24359.1 - 0.00022 21.2 0.9 0.0006 19.9 0.9 1.8 1 0 0 1 1 1 1 WW domain NTF2 PF02136.20 ETO24360.1 - 6.1e-07 30.0 4.8 1.6e-05 25.5 3.0 3.0 1 1 1 2 2 2 1 Nuclear transport factor 2 (NTF2) domain DUF2054 PF10218.9 ETO24360.1 - 0.01 15.9 0.1 0.023 14.8 0.1 1.6 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2054) UBA_4 PF14555.6 ETO24360.1 - 0.022 14.5 0.1 0.078 12.8 0.1 2.0 1 0 0 1 1 1 0 UBA-like domain TAP_C PF03943.13 ETO24360.1 - 0.1 12.3 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 TAP C-terminal domain AF-4 PF05110.13 ETO24361.1 - 0.0056 14.9 45.6 0.0088 14.2 45.6 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein ATG2_CAD PF13329.6 ETO24363.1 - 0.0029 17.4 0.6 0.14 11.9 0.0 2.9 2 0 0 2 2 2 1 Autophagy-related protein 2 CAD motif NOA36 PF06524.12 ETO24363.1 - 1.3 8.3 19.5 3.3 7.0 19.5 1.7 1 0 0 1 1 1 0 NOA36 protein CytochromB561_N PF09786.9 ETO24365.1 - 0.013 14.6 18.4 0.011 14.8 15.0 2.0 2 0 0 2 2 2 0 Cytochrome B561, N terminal ANAPC1 PF12859.7 ETO24365.1 - 1.8 9.2 12.8 0.33 11.5 8.2 2.2 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 1 Suf PF05843.14 ETO24365.1 - 5.5 6.9 8.3 0.94 9.4 3.0 2.2 3 0 0 3 3 3 0 Suppressor of forked protein (Suf) Apt1 PF10351.9 ETO24365.1 - 6.9 5.4 21.9 0.32 9.8 15.7 1.8 2 0 0 2 2 2 0 Golgi-body localisation protein domain zf-TRAF PF02176.18 ETO24366.1 - 7.6e-06 26.5 1.5 7.6e-06 26.5 1.5 3.8 4 1 0 4 4 4 1 TRAF-type zinc finger SF3a60_bindingd PF12108.8 ETO24366.1 - 0.028 14.3 0.1 0.077 12.9 0.1 1.6 1 0 0 1 1 1 0 Splicing factor SF3a60 binding domain DUF641 PF04859.12 ETO24366.1 - 1.9 8.8 11.6 0.52 10.7 0.9 2.6 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) DUF4834 PF16118.5 ETO24368.1 - 0.17 12.9 0.7 19 6.3 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Secretin_N_2 PF07655.13 ETO24368.1 - 1.4 9.5 19.2 0.98 10.0 11.2 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Orf78 PF06024.12 ETO24368.1 - 1.5 9.2 6.9 0.18 12.1 2.0 1.9 2 0 0 2 2 2 0 Orf78 (ac78) Pkinase PF00069.25 ETO24369.1 - 5.2e-54 183.4 0.0 9.8e-53 179.2 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24369.1 - 3.2e-27 95.5 0.0 1.5e-25 89.9 0.0 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO24369.1 - 0.00022 20.7 0.3 0.00059 19.3 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO24369.1 - 0.0081 16.1 0.0 0.018 14.9 0.0 1.6 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO24369.1 - 0.013 14.8 0.0 0.024 14.0 0.0 1.5 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 ETO24369.1 - 0.045 12.7 0.1 0.17 10.8 0.1 1.8 1 1 0 1 1 1 0 Haspin like kinase domain FTA2 PF13095.6 ETO24369.1 - 0.083 12.5 0.0 0.15 11.7 0.0 1.4 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 DUF87 PF01935.17 ETO24370.1 - 0.0047 17.1 0.8 0.0056 16.8 0.8 1.2 1 0 0 1 1 1 1 Helicase HerA, central domain DUF4770 PF15994.5 ETO24371.1 - 0.01 16.1 0.6 0.01 16.1 0.6 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) P-mevalo_kinase PF04275.14 ETO24371.1 - 0.012 15.6 0.5 0.02 14.8 0.5 1.4 1 0 0 1 1 1 0 Phosphomevalonate kinase SSP160 PF06933.11 ETO24371.1 - 0.69 8.0 21.8 0.96 7.6 21.8 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MFMR_assoc PF16596.5 ETO24371.1 - 0.92 10.0 12.3 2.7 8.4 0.2 2.3 2 0 0 2 2 2 0 Disordered region downstream of MFMR Mucin PF01456.17 ETO24371.1 - 2.1 8.3 33.5 0.27 11.2 27.1 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3527 PF12043.8 ETO24371.1 - 5.6 6.4 7.5 0.2 11.2 0.9 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) CPSF100_C PF13299.6 ETO24371.1 - 7.5 6.7 9.6 17 5.5 0.6 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Presenilin PF01080.17 ETO24371.1 - 7.9 5.1 6.8 10 4.8 2.1 2.0 2 0 0 2 2 2 0 Presenilin DUF21 PF01595.20 ETO24372.1 - 3.5e-24 85.5 0.0 6.3e-24 84.6 0.0 1.4 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETO24372.1 - 1.6e-05 25.3 0.1 0.027 14.9 0.0 3.3 3 0 0 3 3 3 2 CBS domain DUF1445 PF07286.12 ETO24374.1 - 4.6e-05 23.4 0.6 7.4e-05 22.7 0.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1445) VPS13_C PF16909.5 ETO24375.1 - 1.5e-54 184.5 5.1 8.5e-53 178.8 0.2 2.9 2 1 0 2 2 2 2 Vacuolar-sorting-associated 13 protein C-terminal ATG_C PF09333.11 ETO24375.1 - 5e-05 23.6 0.3 0.0026 18.1 0.2 3.2 2 1 1 3 3 3 1 Autophagy-related protein C terminal domain Nup192 PF11894.8 ETO24376.1 - 8.8e-18 63.0 1.2 1.2e-17 62.6 1.2 1.0 1 0 0 1 1 1 1 Nuclear pore complex scaffold, nucleoporins 186/192/205 Menin PF05053.13 ETO24377.1 - 0.03 12.7 10.6 0.04 12.3 10.6 1.3 1 0 0 1 1 1 0 Menin Nop14 PF04147.12 ETO24377.1 - 0.96 7.6 18.6 1.1 7.4 18.6 1.0 1 0 0 1 1 1 0 Nop14-like family CCSAP PF15748.5 ETO24377.1 - 1.5 8.9 13.3 2.1 8.5 13.3 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated LRR_RI_capping PF18779.1 ETO24379.1 - 0.11 12.2 0.1 1.6 8.5 0.1 2.5 2 0 0 2 2 2 0 Capping Ribonuclease inhibitor Leucine Rich Repeat DUF4407 PF14362.6 ETO24379.1 - 0.63 9.3 34.1 0.6 9.4 10.9 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4407) YtxH PF12732.7 ETO24379.1 - 2.5 8.7 9.3 4.4 7.9 0.0 4.6 3 2 0 3 3 3 0 YtxH-like protein VEGF_C PF14554.6 ETO24379.1 - 2.8 8.1 5.6 16 5.7 0.1 3.3 2 1 0 3 3 3 0 VEGF heparin-binding domain Cas6b_C PF17262.2 ETO24379.1 - 6 7.0 11.8 0.57 10.3 0.2 3.5 3 0 0 3 3 3 0 Cas6b C-terminal domain Kelch_6 PF13964.6 ETO24380.1 - 1.7e-09 37.6 3.8 0.0032 17.7 0.1 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO24380.1 - 2.7e-08 33.3 0.5 5.6e-06 25.8 0.0 3.2 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO24380.1 - 8.2e-05 22.4 2.1 0.12 12.4 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO24380.1 - 0.0015 18.7 0.0 0.013 15.8 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Peptidase_C14 PF00656.22 ETO24381.1 - 1.8e-12 47.8 0.7 2.6e-12 47.2 0.7 1.3 1 0 0 1 1 1 1 Caspase domain RasGEF PF00617.19 ETO24383.1 - 1.1e-44 152.8 1.8 2.5e-44 151.6 1.8 1.7 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETO24383.1 - 8.5e-05 22.7 0.6 8.5e-05 22.7 0.6 3.0 2 1 0 2 2 2 1 RasGEF N-terminal motif Cid2 PF09774.9 ETO24384.1 - 0.044 14.2 0.1 0.091 13.2 0.1 1.4 1 0 0 1 1 1 0 Caffeine-induced death protein 2 Ninjurin PF04923.12 ETO24384.1 - 0.049 13.6 1.0 0.094 12.7 0.9 1.6 1 1 0 1 1 1 0 Ninjurin DUF3899 PF13038.6 ETO24384.1 - 0.071 13.6 0.6 0.14 12.7 0.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) AhpC-TSA PF00578.21 ETO24385.1 - 0.0025 17.7 0.1 0.0047 16.8 0.1 1.4 1 0 0 1 1 1 1 AhpC/TSA family DUF2608 PF11019.8 ETO24385.1 - 0.0026 17.3 0.1 0.0088 15.6 0.1 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2608) Redoxin PF08534.10 ETO24385.1 - 0.022 14.5 0.0 0.031 14.0 0.0 1.2 1 0 0 1 1 1 0 Redoxin DOCK_N PF16172.5 ETO24386.1 - 0.032 13.2 6.1 0.72 8.7 1.2 2.3 2 0 0 2 2 2 0 DOCK N-terminus RSB_motif PF16294.5 ETO24386.1 - 0.044 14.0 1.1 0.044 14.0 1.1 3.7 3 1 0 3 3 3 0 RNSP1-SAP18 binding (RSB) motif OAD_gamma PF04277.13 ETO24386.1 - 0.047 14.3 1.0 11 6.6 0.0 3.4 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF5531 PF17671.1 ETO24386.1 - 0.065 13.1 0.1 0.065 13.1 0.1 2.6 4 0 0 4 4 4 0 Family of unknown function (DUF5531) RPOL_N PF14700.6 ETO24386.1 - 0.08 12.3 0.0 0.08 12.3 0.0 2.2 2 1 0 2 2 1 0 DNA-directed RNA polymerase N-terminal DUF4834 PF16118.5 ETO24386.1 - 0.13 13.3 23.4 1.6 9.7 0.0 4.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) DUF2448 PF10476.9 ETO24386.1 - 0.41 10.5 3.4 0.42 10.4 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) DUF4820 PF16091.5 ETO24386.1 - 1.1 8.6 13.5 1.1 8.6 1.8 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) GRP PF07172.11 ETO24386.1 - 2.1 9.1 0.0 2.1 9.1 0.0 3.3 4 0 0 4 4 4 0 Glycine rich protein family FAM176 PF14851.6 ETO24386.1 - 3.2 7.4 14.4 27 4.4 0.0 4.1 4 0 0 4 4 4 0 FAM176 family DUF2140 PF09911.9 ETO24386.1 - 5 6.6 8.4 9.5 5.7 0.2 2.9 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) Tim54 PF11711.8 ETO24386.1 - 6.5 5.4 14.1 0.68 8.6 0.1 2.9 2 1 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO24387.1 - 2.2e-34 119.1 3.4 2.6e-34 118.9 3.4 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter DUF5379 PF17350.2 ETO24387.1 - 0.33 11.2 4.9 2.1 8.7 0.2 2.6 1 1 1 2 2 2 0 Family of unknown function (DUF5379) MA3 PF02847.17 ETO24389.1 - 0.048 13.6 0.3 0.45 10.5 0.1 2.5 2 0 0 2 2 2 0 MA3 domain Peptidase_S49_N PF08496.10 ETO24389.1 - 1.5 8.8 5.5 0.65 10.0 1.3 2.1 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RGS PF00615.19 ETO24390.1 - 0.004 17.4 0.7 0.0078 16.5 0.1 1.9 1 1 1 2 2 2 1 Regulator of G protein signaling domain DUF908 PF06012.12 ETO24390.1 - 0.021 14.3 3.4 0.027 13.9 3.4 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Merozoite_SPAM PF07133.11 ETO24390.1 - 0.69 9.9 29.0 0.99 9.4 29.0 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop53 PF07767.11 ETO24390.1 - 0.7 9.2 24.4 1 8.7 24.4 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Zip PF02535.22 ETO24390.1 - 0.71 9.0 3.3 0.74 9.0 3.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO24390.1 - 2.4 6.8 10.7 2.7 6.6 10.7 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO24390.1 - 2.7 6.2 22.8 3.4 5.9 22.8 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO24390.1 - 4.7 7.3 26.5 6.1 6.9 26.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Neur_chan_memb PF02932.16 ETO24390.1 - 6.2 6.8 6.1 8.8 6.3 6.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO24391.1 - 0.016 13.5 5.1 0.02 13.2 5.1 1.0 1 0 0 1 1 1 0 CDC45-like protein BLOC1S3 PF15753.5 ETO24391.1 - 0.016 15.3 3.2 0.021 14.9 3.2 1.2 1 0 0 1 1 1 0 Biogenesis of lysosome-related organelles complex 1 subunit 3 SAM_2 PF07647.17 ETO24392.1 - 2.4e-05 24.3 0.0 4e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO24392.1 - 0.0017 18.8 0.0 0.0027 18.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) BSP_II PF05432.11 ETO24392.1 - 0.1 12.3 17.7 0.14 11.8 17.7 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SOBP PF15279.6 ETO24392.1 - 4.4 7.8 9.0 6.7 7.2 9.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Ank_2 PF12796.7 ETO24393.1 - 5.6e-15 55.7 8.5 0.0015 19.0 0.2 4.4 3 1 0 4 4 4 4 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO24393.1 - 5.8e-13 49.1 11.2 0.0015 19.1 0.0 6.2 4 2 3 7 7 7 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO24393.1 - 3.2e-11 43.2 8.7 0.0042 17.4 0.0 7.0 5 2 2 7 7 7 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO24393.1 - 5e-08 32.6 6.7 0.81 10.5 0.0 6.7 6 0 0 6 6 6 3 Ankyrin repeat Ank PF00023.30 ETO24393.1 - 0.0039 17.6 6.3 38 5.0 0.0 5.4 5 1 0 5 5 5 0 Ankyrin repeat AstE_AspA PF04952.14 ETO24394.1 - 2.5e-45 154.8 0.0 2.7e-45 154.7 0.0 1.0 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family GAD-like PF08887.11 ETO24394.1 - 0.15 11.9 0.0 0.67 9.7 0.0 1.9 2 0 0 2 2 2 0 GAD-like domain Ndc1_Nup PF09531.10 ETO24395.1 - 6.6 5.3 10.7 1.8 7.2 1.4 2.1 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup EF-hand_1 PF00036.32 ETO24396.1 - 0.0013 18.1 2.2 0.78 9.4 0.0 4.0 4 0 0 4 4 4 2 EF hand EF-hand_7 PF13499.6 ETO24396.1 - 0.0025 18.2 2.5 2.3 8.7 0.3 3.0 2 2 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO24396.1 - 0.015 15.2 0.2 7.4 6.8 0.0 3.5 3 0 0 3 3 3 0 EF-hand domain EF-hand_8 PF13833.6 ETO24396.1 - 0.033 14.0 0.2 5.4 6.9 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain pair Kinesin PF00225.23 ETO24397.1 - 2.3e-41 141.8 0.0 2.4e-41 141.7 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO24397.1 - 8.4e-27 93.9 0.0 9.8e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 Microtubule binding Atg31 PF09795.9 ETO24398.1 - 0.43 10.6 6.8 0.64 10.0 6.8 1.3 1 0 0 1 1 1 0 Autophagy-related protein 31 Piezo_RRas_bdg PF12166.8 ETO24399.1 - 3.7e-38 131.9 0.2 4.7e-38 131.6 0.2 1.0 1 0 0 1 1 1 1 Piezo non-specific cation channel, R-Ras-binding domain Peptidase_S28 PF05577.12 ETO24400.1 - 9.7e-71 238.8 3.0 1.2e-70 238.5 3.0 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase S28 rpo132 PF12415.8 ETO24400.1 - 0.075 12.3 0.1 0.17 11.2 0.1 1.6 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase DUF2920 PF11144.8 ETO24400.1 - 0.11 11.7 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2920) Cullin_Nedd8 PF10557.9 ETO24401.1 - 2.2e-27 94.8 2.1 2.2e-27 94.8 2.1 1.9 2 0 0 2 2 2 1 Cullin protein neddylation domain Cullin PF00888.22 ETO24401.1 - 3.2e-12 45.9 0.2 3.2e-12 45.9 0.2 1.7 2 0 0 2 2 2 1 Cullin family Penicillinase_R PF03965.16 ETO24401.1 - 0.035 14.5 0.1 0.096 13.0 0.0 1.8 2 0 0 2 2 2 0 Penicillinase repressor DUF515 PF04415.12 ETO24401.1 - 0.059 11.8 0.5 0.077 11.4 0.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Cullin PF00888.22 ETO24402.1 - 1.3e-24 86.8 5.8 1.5e-24 86.6 5.8 1.0 1 0 0 1 1 1 1 Cullin family Methyltransf_3 PF01596.17 ETO24403.1 - 7.7e-25 87.3 0.1 1.1e-24 86.8 0.1 1.2 1 0 0 1 1 1 1 O-methyltransferase Methyltransf_24 PF13578.6 ETO24403.1 - 0.00029 21.8 0.0 0.00054 21.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO24403.1 - 0.00075 20.2 0.0 0.0014 19.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO24403.1 - 0.05 12.9 0.0 0.066 12.5 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family GCD14 PF08704.10 ETO24403.1 - 0.15 11.7 0.0 0.32 10.6 0.0 1.5 1 1 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Methyltransf_11 PF08241.12 ETO24403.1 - 0.17 12.6 0.0 0.3 11.8 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase domain DUF2439 PF10382.9 ETO24404.1 - 0.047 14.0 0.6 0.12 12.7 0.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2439) DUF4684 PF15736.5 ETO24405.1 - 0.21 10.2 0.2 0.29 9.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4684) Thiol_cytolys_C PF17440.2 ETO24406.1 - 0.05 13.8 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 Thiol-activated cytolysin beta sandwich domain Synapsin PF02078.16 ETO24406.1 - 0.13 12.6 0.0 0.2 11.9 0.0 1.4 1 0 0 1 1 1 0 Synapsin, N-terminal domain ELMO_CED12 PF04727.13 ETO24407.1 - 1.3e-19 71.0 1.9 2.1e-19 70.3 0.5 2.0 2 1 0 2 2 2 1 ELMO/CED-12 family HTH_29 PF13551.6 ETO24409.1 - 0.11 12.5 1.9 0.3 11.2 0.0 2.3 2 0 0 2 2 2 0 Winged helix-turn helix K_channel_TID PF07941.11 ETO24409.1 - 7.3 7.1 13.7 16 6.0 12.7 2.1 1 1 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain EF-hand_6 PF13405.6 ETO24410.1 - 0.14 12.2 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain H_PPase PF03030.16 ETO24411.1 - 1.2e-23 83.6 9.7 2.1e-22 79.5 9.5 2.1 1 1 0 1 1 1 1 Inorganic H+ pyrophosphatase DUF5305 PF17231.2 ETO24411.1 - 5.2 6.4 5.6 4.1 6.8 0.1 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5305) zf-C2H2_9 PF16293.5 ETO24412.1 - 0.066 13.1 0.0 0.22 11.4 0.0 1.8 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) PHO4 PF01384.20 ETO24412.1 - 0.089 11.8 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphate transporter family DUF4611 PF15387.6 ETO24412.1 - 0.28 11.4 18.2 0.12 12.7 1.7 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) UreE_C PF05194.12 ETO24412.1 - 3 8.4 11.8 0.58 10.7 4.5 3.1 3 0 0 3 3 3 0 UreE urease accessory protein, C-terminal domain RXT2_N PF08595.11 ETO24412.1 - 7.1 6.6 23.3 0.64 10.0 2.3 4.2 4 0 0 4 4 4 0 RXT2-like, N-terminal HSP70 PF00012.20 ETO24413.1 - 0.00027 19.3 0.0 0.0012 17.2 0.0 1.7 1 1 0 1 1 1 1 Hsp70 protein Peptidase_M22 PF00814.25 ETO24413.1 - 0.0092 15.7 0.0 0.015 15.0 0.0 1.5 1 0 0 1 1 1 1 Glycoprotease family DUF1600 PF07667.11 ETO24414.1 - 0.011 16.0 4.1 0.023 14.9 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1600) Orf78 PF06024.12 ETO24414.1 - 0.019 15.2 4.4 0.019 15.2 4.4 2.2 2 0 0 2 2 2 0 Orf78 (ac78) EphA2_TM PF14575.6 ETO24414.1 - 0.032 15.1 0.2 0.088 13.7 0.2 1.8 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain UPF0697 PF15117.6 ETO24414.1 - 0.083 13.0 0.1 0.083 13.0 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein family UPF0697 PEPCK_ATP PF01293.20 ETO24414.1 - 0.11 11.1 1.4 0.11 11.1 0.0 1.6 2 0 0 2 2 2 0 Phosphoenolpyruvate carboxykinase PIRT PF15099.6 ETO24414.1 - 0.12 12.0 0.7 0.24 11.0 0.7 1.5 1 0 0 1 1 1 0 Phosphoinositide-interacting protein family TMEM154 PF15102.6 ETO24414.1 - 0.32 10.9 6.5 0.041 13.8 1.8 1.8 2 0 0 2 2 2 0 TMEM154 protein family 7TM-7TMR_HD PF07698.11 ETO24414.1 - 2 8.1 14.3 11 5.7 9.7 2.9 1 1 2 3 3 3 0 7TM receptor with intracellular HD hydrolase Ly49 PF08391.10 ETO24414.1 - 2.9 8.3 7.9 0.17 12.3 1.5 2.2 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region DUF4834 PF16118.5 ETO24414.1 - 3.5 8.7 5.8 2.6 9.1 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Tim17 PF02466.19 ETO24415.1 - 2.3e-05 24.7 0.3 5.4e-05 23.5 0.2 1.5 1 1 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family DUF2109 PF09882.9 ETO24415.1 - 4.7 7.3 5.2 0.97 9.5 0.1 2.5 3 0 0 3 3 3 0 Predicted membrane protein (DUF2109) YL1 PF05764.13 ETO24417.1 - 0.029 14.5 14.1 0.035 14.2 14.1 1.0 1 0 0 1 1 1 0 YL1 nuclear protein Dsh_C PF12316.8 ETO24417.1 - 0.43 11.0 9.3 0.56 10.6 9.3 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Merozoite_SPAM PF07133.11 ETO24417.1 - 0.88 9.5 19.5 1.1 9.2 19.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) DUF572 PF04502.13 ETO24417.1 - 0.92 9.1 13.2 0.94 9.0 13.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Hydin_ADK PF17213.3 ETO24417.1 - 1.2 9.3 9.8 1.5 9.1 9.8 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Suf PF05843.14 ETO24417.1 - 5.6 6.9 9.7 6.5 6.6 9.7 1.0 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Macoilin PF09726.9 ETO24417.1 - 6.7 5.1 13.3 7.8 4.9 13.3 1.1 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 ETO24417.1 - 7.1 4.8 16.2 8.2 4.6 16.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Ly49 PF08391.10 ETO24417.1 - 8 6.9 6.7 11 6.4 6.7 1.1 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Lipoxygenase PF00305.19 ETO24418.1 - 0.0008 18.0 0.1 0.00087 17.8 0.1 1.1 1 0 0 1 1 1 1 Lipoxygenase DUF2623 PF11115.8 ETO24418.1 - 0.16 12.1 0.0 0.27 11.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2623) GTP_EFTU PF00009.27 ETO24419.1 - 0.072 12.6 0.0 0.13 11.8 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Suppressor_P21 PF11479.8 ETO24419.1 - 0.091 13.0 2.0 0.14 12.4 0.0 2.3 3 1 0 3 3 3 0 RNA silencing suppressor P21 C-terminal domain Xpo1 PF08389.12 ETO24420.1 - 1.1e-11 44.9 1.1 1.1e-11 44.9 1.1 2.9 3 0 0 3 3 3 1 Exportin 1-like protein LrgB PF04172.16 ETO24421.1 - 0.016 14.7 2.3 3.1 7.3 0.5 2.1 1 1 0 2 2 2 0 LrgB-like family SLED PF12140.8 ETO24422.1 - 7 7.2 16.0 0.11 13.0 1.7 3.4 3 0 0 3 3 3 0 SLED domain ELM2 PF01448.24 ETO24423.1 - 2.4e-07 31.4 0.4 5.9e-07 30.1 0.4 1.7 1 0 0 1 1 1 1 ELM2 domain ARID PF01388.21 ETO24423.1 - 0.00069 20.2 0.1 0.0015 19.2 0.1 1.7 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain VASP_tetra PF08776.11 ETO24424.1 - 0.016 14.8 6.4 0.018 14.6 0.6 2.7 2 0 0 2 2 2 0 VASP tetramerisation domain Apolipoprotein PF01442.18 ETO24424.1 - 0.14 12.0 9.6 0.17 11.7 9.6 1.1 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain betaPIX_CC PF16523.5 ETO24424.1 - 0.38 10.6 8.5 0.32 10.8 4.6 2.2 1 1 1 2 2 2 0 betaPIX coiled coil Baculo_PEP_C PF04513.12 ETO24424.1 - 0.48 10.5 5.3 9.5 6.3 0.1 2.1 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF919 PF06034.11 ETO24424.1 - 0.52 10.2 17.0 0.096 12.5 5.4 3.4 2 1 2 4 4 4 0 Nucleopolyhedrovirus protein of unknown function (DUF919) OmpH PF03938.14 ETO24424.1 - 0.9 9.9 22.1 0.028 14.8 11.8 2.0 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF2115 PF09888.9 ETO24424.1 - 1.4 9.4 9.3 1.9 9.0 9.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Exonuc_VII_L PF02601.15 ETO24424.1 - 1.6 8.2 11.8 2 7.9 11.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit RRF PF01765.19 ETO24424.1 - 1.6 8.7 12.3 1.6 8.6 10.7 1.8 1 1 1 2 2 2 0 Ribosome recycling factor DUF883 PF05957.13 ETO24424.1 - 1.6 9.3 5.3 11 6.7 1.0 2.1 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) Phage_Mu_Gam PF07352.12 ETO24424.1 - 1.9 8.4 19.6 1.7e+03 -1.2 19.6 2.2 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein DUF4407 PF14362.6 ETO24424.1 - 2.4 7.4 8.7 2.9 7.2 8.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 ETO24424.1 - 2.5 7.1 9.4 2.9 6.9 9.4 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 RtcB PF01139.17 ETO24424.1 - 2.7 7.1 7.9 0.64 9.1 2.8 1.9 1 1 1 2 2 2 0 tRNA-splicing ligase RtcB YtxH PF12732.7 ETO24424.1 - 3.1 8.4 5.7 26 5.4 5.7 2.3 1 1 0 1 1 1 0 YtxH-like protein DUF1451 PF07295.11 ETO24424.1 - 3.8 7.5 12.3 5.5 7.0 2.9 2.1 1 1 1 2 2 2 0 Zinc-ribbon containing domain Uso1_p115_C PF04871.13 ETO24424.1 - 3.8 7.9 16.9 1.6 9.1 10.3 2.0 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF1664 PF07889.12 ETO24424.1 - 4.1 7.5 8.2 5.4 7.1 6.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Mer2 PF09074.10 ETO24424.1 - 4.1 7.2 14.8 5.9 6.7 14.8 1.4 1 1 0 1 1 1 0 Mer2 Peptidase_C65 PF10275.9 ETO24425.1 - 4.8e-50 170.3 0.7 1.5e-25 90.1 0.0 2.2 1 1 1 2 2 2 2 Peptidase C65 Otubain OTU PF02338.19 ETO24425.1 - 4.2e-06 27.3 1.5 0.014 15.9 0.0 2.8 2 1 1 3 3 3 2 OTU-like cysteine protease TPK_B1_binding PF04265.14 ETO24426.1 - 0.12 12.2 0.2 0.47 10.2 0.0 2.1 2 0 0 2 2 2 0 Thiamin pyrophosphokinase, vitamin B1 binding domain 7TMR-DISM_7TM PF07695.11 ETO24427.1 - 0.093 12.6 16.7 0.068 13.1 8.1 2.5 2 1 0 2 2 2 0 7TM diverse intracellular signalling BaxI_1 PF12811.7 ETO24427.1 - 0.15 11.6 5.4 0.038 13.6 0.9 1.9 2 0 0 2 2 2 0 Bax inhibitor 1 like DUF2583 PF10762.9 ETO24427.1 - 1.7 9.1 5.9 20 5.7 2.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2583) TPR_1 PF00515.28 ETO24428.1 - 7.9e-12 44.5 1.2 0.0087 15.9 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24428.1 - 6.7e-10 38.3 0.1 0.018 15.1 0.0 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24428.1 - 1.5e-07 30.9 0.8 0.22 11.2 0.0 4.6 3 1 1 4 4 4 2 TPR repeat TPR_8 PF13181.6 ETO24428.1 - 1.8e-07 30.8 0.9 0.071 13.4 0.0 4.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24428.1 - 0.00053 20.2 0.1 4.1 7.8 0.1 3.8 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24428.1 - 0.0026 18.0 0.1 0.27 11.7 0.0 3.9 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO24428.1 - 0.0028 17.8 0.0 0.013 15.7 0.0 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ETO24428.1 - 0.0041 17.0 0.0 0.76 10.0 0.0 3.1 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETO24428.1 - 0.0043 17.1 0.1 6.1 7.0 0.0 3.3 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO24428.1 - 0.0079 16.7 0.1 0.074 13.6 0.0 2.6 3 0 0 3 3 3 1 Tetratricopeptide repeat GerD PF17898.1 ETO24428.1 - 0.088 12.8 2.6 0.31 11.0 2.6 1.9 1 1 0 1 1 1 0 Spore germination GerD central core domain TPR_9 PF13371.6 ETO24428.1 - 0.17 12.1 0.0 0.96 9.6 0.0 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat DAP_B PF07930.12 ETO24431.1 - 3.1 7.8 12.1 3.8 7.5 1.8 3.8 3 0 0 3 3 3 0 D-aminopeptidase, domain B DUF3377 PF11857.8 ETO24432.1 - 0.087 12.8 0.6 0.087 12.8 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3377) DUF2207 PF09972.9 ETO24432.1 - 0.15 10.8 1.6 0.18 10.5 1.6 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) APG6_N PF17675.1 ETO24433.1 - 0.0039 17.7 14.8 0.0046 17.5 14.8 1.2 1 0 0 1 1 1 1 Apg6 coiled-coil region zf-C4H2 PF10146.9 ETO24433.1 - 0.0083 16.5 7.6 0.0091 16.3 7.6 1.1 1 0 0 1 1 1 1 Zinc finger-containing protein SYCE1 PF15233.6 ETO24433.1 - 0.018 15.1 12.3 0.019 15.0 12.3 1.1 1 0 0 1 1 1 0 Synaptonemal complex central element protein 1 CENP-H PF05837.12 ETO24433.1 - 0.026 14.9 10.1 0.036 14.5 10.1 1.2 1 0 0 1 1 1 0 Centromere protein H (CENP-H) EzrA PF06160.12 ETO24433.1 - 0.063 11.4 10.1 0.072 11.3 10.1 1.1 1 0 0 1 1 1 0 Septation ring formation regulator, EzrA Cortex-I_coil PF09304.10 ETO24433.1 - 0.063 13.5 11.9 0.065 13.4 11.1 1.5 1 1 1 2 2 2 0 Cortexillin I, coiled coil Spc7 PF08317.11 ETO24433.1 - 0.11 11.4 14.6 0.12 11.3 14.6 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Tup_N PF08581.10 ETO24433.1 - 0.19 12.1 8.0 4.3 7.7 8.0 2.1 1 1 0 1 1 1 0 Tup N-terminal Bcr-Abl_Oligo PF09036.10 ETO24433.1 - 0.21 11.6 4.1 2 8.5 0.3 2.2 1 1 1 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Golgin_A5 PF09787.9 ETO24433.1 - 0.25 10.8 11.8 0.3 10.5 11.8 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 XhlA PF10779.9 ETO24433.1 - 0.26 11.5 7.7 0.89 9.8 2.9 2.3 1 1 0 2 2 2 0 Haemolysin XhlA Troponin PF00992.20 ETO24433.1 - 0.4 11.0 12.3 0.99 9.7 12.3 1.6 1 1 0 1 1 1 0 Troponin TMPIT PF07851.13 ETO24433.1 - 0.53 9.5 7.9 0.57 9.4 7.9 1.1 1 0 0 1 1 1 0 TMPIT-like protein THOC7 PF05615.13 ETO24433.1 - 0.59 10.4 10.1 0.91 9.8 10.1 1.4 1 1 0 1 1 1 0 Tho complex subunit 7 DUF3450 PF11932.8 ETO24433.1 - 0.61 9.3 8.5 0.73 9.1 8.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DASH_Spc34 PF08657.10 ETO24433.1 - 0.67 9.7 12.4 0.62 9.8 3.5 2.0 1 1 1 2 2 2 0 DASH complex subunit Spc34 Prefoldin PF02996.17 ETO24433.1 - 0.84 9.6 11.3 0.86 9.5 1.5 2.2 2 0 0 2 2 2 0 Prefoldin subunit AATF-Che1 PF13339.6 ETO24433.1 - 0.94 10.2 10.5 1.7 9.3 10.5 1.6 1 1 0 1 1 1 0 Apoptosis antagonizing transcription factor I_LWEQ PF01608.17 ETO24433.1 - 0.97 9.7 8.5 1.3 9.3 8.5 1.2 1 0 0 1 1 1 0 I/LWEQ domain DUF1664 PF07889.12 ETO24433.1 - 1.1 9.4 6.3 1.4 9.0 6.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 ETO24433.1 - 1.3 8.0 11.5 1.7 7.7 11.5 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Prominin PF05478.11 ETO24433.1 - 1.4 6.7 7.9 1.6 6.6 7.9 1.0 1 0 0 1 1 1 0 Prominin DUF4094 PF13334.6 ETO24433.1 - 1.8 9.0 6.9 3.3 8.2 5.3 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4094) HemX PF04375.14 ETO24433.1 - 2.2 7.5 10.7 2.3 7.4 10.1 1.3 1 1 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase Nup88 PF10168.9 ETO24433.1 - 2.7 5.7 10.0 2.9 5.6 10.0 1.0 1 0 0 1 1 1 0 Nuclear pore component Sec2p PF06428.11 ETO24433.1 - 3.1 7.8 14.1 0.86 9.6 3.9 2.4 1 1 0 1 1 1 0 GDP/GTP exchange factor Sec2p V_ATPase_I PF01496.19 ETO24433.1 - 4.1 5.2 7.4 4.6 5.0 7.4 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CCDC-167 PF15188.6 ETO24433.1 - 4.4 7.7 11.1 2.3 8.6 0.6 2.2 1 1 0 2 2 2 0 Coiled-coil domain-containing protein 167 Csm1_N PF18504.1 ETO24433.1 - 4.4 7.7 13.5 8.4 6.8 8.7 2.3 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF4407 PF14362.6 ETO24433.1 - 8.5 5.6 11.0 22 4.3 11.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Bap31_Bap29_C PF18035.1 ETO24433.1 - 8.7 6.4 14.7 0.96 9.5 0.8 2.8 1 1 2 3 3 3 0 Bap31/Bap29 cytoplasmic coiled-coil domain ASFV_J13L PF05568.11 ETO24434.1 - 0.022 14.5 0.7 5.5 6.7 0.0 2.6 1 1 1 2 2 2 0 African swine fever virus J13L protein DUF678 PF05077.12 ETO24435.1 - 0.36 11.0 3.0 0.83 9.8 3.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF678) CrgA PF06781.12 ETO24435.1 - 1.9 8.6 6.1 14 5.9 0.1 3.2 2 1 1 3 3 3 0 Cell division protein CrgA Peptidase_C48 PF02902.19 ETO24435.1 - 4.4 7.1 9.2 0.14 12.0 0.4 2.2 2 0 0 2 2 2 0 Ulp1 protease family, C-terminal catalytic domain GCD14 PF08704.10 ETO24436.1 - 2.4e-79 266.5 4.7 9.4e-43 146.7 0.0 3.2 1 1 2 3 3 3 3 tRNA methyltransferase complex GCD14 subunit GCD14_N PF14801.6 ETO24436.1 - 2.1e-06 27.5 0.1 4.2e-06 26.5 0.1 1.5 1 0 0 1 1 1 1 tRNA methyltransferase complex GCD14 subunit N-term Methyltransf_31 PF13847.6 ETO24436.1 - 0.00019 21.2 2.4 0.0012 18.6 2.4 2.4 1 1 0 1 1 1 1 Methyltransferase domain TFIIA PF03153.13 ETO24436.1 - 0.0036 17.4 31.6 0.0036 17.4 31.6 1.5 2 0 0 2 2 1 1 Transcription factor IIA, alpha/beta subunit DUF2076 PF09849.9 ETO24436.1 - 0.02 14.9 29.3 0.02 14.9 29.3 2.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2076) Serinc PF03348.15 ETO24436.1 - 0.021 13.8 1.2 0.038 12.9 1.2 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Ctr PF04145.15 ETO24436.1 - 0.028 15.0 1.5 0.12 13.0 1.2 2.0 2 0 0 2 2 2 0 Ctr copper transporter family PAT1 PF09770.9 ETO24436.1 - 0.11 10.8 24.2 0.16 10.2 24.2 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Neur_chan_memb PF02932.16 ETO24436.1 - 0.11 12.6 6.5 0.031 14.3 3.6 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region CCDC53 PF10152.9 ETO24436.1 - 0.25 11.8 17.5 0.29 11.5 15.8 1.8 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex eIF-3_zeta PF05091.12 ETO24436.1 - 0.29 10.1 12.3 0.51 9.3 12.3 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) CPSF100_C PF13299.6 ETO24436.1 - 0.42 10.8 9.2 0.41 10.8 6.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pex14_N PF04695.13 ETO24436.1 - 0.53 10.9 31.5 0.069 13.8 27.3 1.6 2 0 0 2 2 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region RR_TM4-6 PF06459.12 ETO24436.1 - 0.76 9.5 13.9 0.81 9.5 10.9 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ALMT PF11744.8 ETO24436.1 - 1.4 7.7 4.4 2.2 7.0 4.4 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4175 PF13779.6 ETO24436.1 - 1.6 6.6 34.5 2.3 6.0 34.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Endostatin PF06482.11 ETO24436.1 - 2.4 7.6 12.9 4.2 6.7 12.9 1.3 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Hid1 PF12722.7 ETO24436.1 - 4 5.5 11.8 5.9 4.9 11.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Tim54 PF11711.8 ETO24436.1 - 5 5.8 16.1 0.66 8.7 11.2 1.8 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Lin-8 PF03353.15 ETO24436.1 - 5.9 6.4 18.5 3.3 7.2 16.3 1.6 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist Phi-29_GP16_7 PF06720.11 ETO24437.1 - 0.34 10.7 4.5 0.57 10.0 0.0 2.9 3 1 0 3 3 3 0 Bacteriophage phi-29 early protein GP16.7 Mgr1 PF08602.10 ETO24437.1 - 1.5 7.5 9.9 0.06 12.2 2.5 2.0 2 0 0 2 2 2 0 Mgr1-like, i-AAA protease complex subunit RGS PF00615.19 ETO24438.1 - 2.1e-09 37.7 1.2 2.6e-08 34.1 0.3 2.5 2 0 0 2 2 2 1 Regulator of G protein signaling domain Ribosomal_L6e_N PF03868.15 ETO24439.1 - 0.54 10.5 2.3 2.4 8.5 2.3 1.9 1 1 0 1 1 1 0 Ribosomal protein L6, N-terminal domain XkdW PF09636.10 ETO24441.1 - 0.085 13.0 0.9 0.18 11.9 0.9 1.5 1 0 0 1 1 1 0 XkdW protein BBS2_Mid PF14783.6 ETO24441.1 - 0.12 12.4 0.1 0.83 9.7 0.0 2.5 2 1 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region RasGAP_C PF03836.15 ETO24441.1 - 0.3 11.2 4.3 0.58 10.3 4.3 1.4 1 0 0 1 1 1 0 RasGAP C-terminus Dsh_C PF12316.8 ETO24442.1 - 3 8.2 11.3 2 8.8 4.7 2.1 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Fe_dep_repr_C PF02742.15 ETO24443.1 - 0.19 11.8 1.5 0.32 11.1 0.4 2.0 2 0 0 2 2 2 0 Iron dependent repressor, metal binding and dimerisation domain WD40 PF00400.32 ETO24446.1 - 1.5e-59 196.6 24.0 9.5e-10 38.9 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24446.1 - 6.5e-23 80.8 3.3 0.0003 21.0 0.1 5.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24446.1 - 2.1e-13 50.0 4.1 0.0052 15.8 0.0 5.7 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO24446.1 - 9.3e-11 42.0 0.1 0.00055 19.9 0.0 3.3 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO24446.1 - 2.9e-07 29.5 7.2 0.35 9.4 0.6 5.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO24446.1 - 2.6e-06 27.0 0.1 0.00011 21.7 0.0 3.0 1 1 1 3 3 3 1 WD40-like domain PD40 PF07676.12 ETO24446.1 - 1.6e-05 24.7 7.1 5.6 7.0 0.1 5.6 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO24446.1 - 0.00035 20.0 1.3 1.5 8.1 0.0 3.7 1 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal HARP PF07443.13 ETO24446.1 - 0.0012 18.5 0.1 16 5.2 0.0 4.8 5 0 0 5 5 5 0 HepA-related protein (HARP) SGL PF08450.12 ETO24446.1 - 0.0017 18.0 0.7 0.011 15.4 0.2 2.2 1 1 0 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO24446.1 - 0.0066 15.0 0.4 2 6.8 0.0 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain DUF1797 PF08796.10 ETO24446.1 - 0.024 14.7 0.0 7.9 6.7 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF1797) Transposase_1 PF01359.18 ETO24446.1 - 0.11 12.3 0.1 28 4.6 0.0 3.2 4 0 0 4 4 4 0 Transposase (partial DDE domain) Proteasome_A_N PF10584.9 ETO24446.1 - 0.13 12.0 3.5 32 4.3 0.0 4.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature SET PF00856.28 ETO24447.1 - 1.3e-06 29.0 1.9 4.3e-05 24.0 0.2 2.8 2 1 0 2 2 2 1 SET domain MORN PF02493.20 ETO24447.1 - 0.31 11.0 2.4 4.4 7.4 1.0 2.9 2 0 0 2 2 2 0 MORN repeat Chordopox_A13L PF05961.11 ETO24448.1 - 0.031 14.5 1.1 0.12 12.6 0.0 2.5 2 0 0 2 2 2 0 Chordopoxvirus A13L protein Prefoldin_2 PF01920.20 ETO24449.1 - 3.2e-10 39.9 3.5 3.2e-10 39.9 3.5 2.2 1 1 1 2 2 2 1 Prefoldin subunit TolA_bind_tri PF16331.5 ETO24449.1 - 1e-06 28.7 6.6 0.003 17.6 4.9 2.1 2 0 0 2 2 2 2 TolA binding protein trimerisation ADIP PF11559.8 ETO24449.1 - 0.00095 19.3 12.1 0.062 13.4 7.3 2.1 2 0 0 2 2 2 2 Afadin- and alpha -actinin-Binding APG6_N PF17675.1 ETO24449.1 - 0.0041 17.6 10.7 0.28 11.7 0.4 2.1 2 0 0 2 2 2 2 Apg6 coiled-coil region DUF3450 PF11932.8 ETO24449.1 - 0.0045 16.3 8.9 0.07 12.4 4.0 2.0 2 0 0 2 2 2 2 Protein of unknown function (DUF3450) CENP-F_leu_zip PF10473.9 ETO24449.1 - 0.017 15.2 16.6 0.22 11.5 16.6 2.0 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SesA PF17107.5 ETO24449.1 - 0.028 14.6 2.3 0.36 11.0 0.3 2.2 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Syntaxin PF00804.25 ETO24449.1 - 0.03 14.0 8.4 0.036 13.7 1.7 2.2 1 1 0 2 2 2 0 Syntaxin DUF724 PF05266.14 ETO24449.1 - 0.044 13.6 11.9 0.35 10.7 6.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) NPV_P10 PF05531.12 ETO24449.1 - 0.046 14.2 0.3 0.046 14.2 0.3 2.5 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Snapin_Pallidin PF14712.6 ETO24449.1 - 0.052 14.0 0.1 0.052 14.0 0.1 2.5 2 1 0 2 2 2 0 Snapin/Pallidin Laminin_II PF06009.12 ETO24449.1 - 0.058 13.4 9.4 1 9.4 0.4 2.3 2 1 0 2 2 2 0 Laminin Domain II EzrA PF06160.12 ETO24449.1 - 0.068 11.3 11.6 0.32 9.1 0.4 2.0 2 0 0 2 2 2 0 Septation ring formation regulator, EzrA AFT PF08731.11 ETO24449.1 - 0.072 13.5 4.1 0.098 13.1 3.9 1.6 1 1 0 1 1 1 0 Transcription factor AFT TPR_MLP1_2 PF07926.12 ETO24449.1 - 0.081 13.0 8.8 3 7.9 4.7 2.2 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein Osmo_CC PF08946.10 ETO24449.1 - 0.1 12.8 0.7 0.1 12.8 0.7 2.8 2 2 1 3 3 3 0 Osmosensory transporter coiled coil DASH_Spc19 PF08287.11 ETO24449.1 - 0.11 12.4 9.2 0.68 9.8 0.4 2.2 2 0 0 2 2 2 0 Spc19 BRE1 PF08647.11 ETO24449.1 - 0.12 12.4 0.1 0.12 12.4 0.1 2.5 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase XhlA PF10779.9 ETO24449.1 - 0.13 12.5 0.6 0.13 12.5 0.6 3.0 2 1 1 3 3 3 0 Haemolysin XhlA DUF1664 PF07889.12 ETO24449.1 - 0.17 11.9 8.1 1 9.4 1.3 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DegS PF05384.11 ETO24449.1 - 0.2 11.1 10.8 2.2 7.7 0.6 2.3 2 1 0 2 2 2 0 Sensor protein DegS DUF812 PF05667.11 ETO24449.1 - 0.22 10.3 13.8 0.23 10.3 5.6 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Spc7 PF08317.11 ETO24449.1 - 0.25 10.2 12.3 0.57 9.0 11.0 1.8 1 1 0 1 1 1 0 Spc7 kinetochore protein FlaC_arch PF05377.11 ETO24449.1 - 0.43 11.0 10.6 4.3 7.8 1.6 3.2 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF5082 PF16888.5 ETO24449.1 - 0.84 9.9 14.1 3.8 7.8 13.9 2.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5082) DHR10 PF18595.1 ETO24449.1 - 1 9.4 15.4 0.43 10.7 0.2 2.4 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain GIT_CC PF16559.5 ETO24449.1 - 1.4 8.8 8.4 3 7.8 3.4 2.7 2 1 1 3 3 3 0 GIT coiled-coil Rho guanine nucleotide exchange factor DivIC PF04977.15 ETO24449.1 - 2.8 7.8 8.4 8.5 6.2 4.7 2.3 2 0 0 2 2 2 0 Septum formation initiator YabA PF06156.13 ETO24449.1 - 3.3 8.4 11.7 11 6.7 4.9 2.2 1 1 0 2 2 2 0 Initiation control protein YabA ZapB PF06005.12 ETO24449.1 - 7.9 7.0 15.5 25 5.4 0.4 2.3 2 0 0 2 2 2 0 Cell division protein ZapB WD40 PF00400.32 ETO24450.1 - 1.9e-37 126.6 25.2 2.6e-05 24.9 0.1 8.1 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24450.1 - 6.4e-14 52.0 5.9 0.02 15.2 0.1 5.7 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24450.1 - 1.3e-11 43.9 8.8 0.0073 15.0 0.9 5.7 2 2 4 6 6 6 5 Nucleoporin Nup120/160 DUF3716 PF12511.8 ETO24451.1 - 0.17 11.9 2.9 0.18 11.9 1.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3716) Topoisom_I_N PF02919.15 ETO24452.1 - 0.14 11.6 5.8 0.3 10.6 5.8 1.5 1 0 0 1 1 1 0 Eukaryotic DNA topoisomerase I, DNA binding fragment DUF3987 PF13148.6 ETO24452.1 - 5.2 6.0 5.6 9.9 5.1 5.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Chalcone PF02431.15 ETO24453.1 - 0.019 14.4 0.2 0.062 12.7 0.0 1.7 2 0 0 2 2 2 0 Chalcone-flavanone isomerase tRNA_bind_3 PF17176.4 ETO24453.1 - 2.4 8.5 5.3 3.7 7.9 1.1 2.6 1 1 0 2 2 2 0 tRNA-binding domain Zip PF02535.22 ETO24453.1 - 6.8 5.8 5.9 11 5.1 5.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4286 PF14114.6 ETO24454.1 - 0.055 14.0 0.2 0.055 14.0 0.2 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4286) BcrAD_BadFG PF01869.20 ETO24455.1 - 0.032 13.7 0.0 0.05 13.1 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family DUF4748 PF15932.5 ETO24459.1 - 0.14 11.9 0.1 0.14 11.9 0.1 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4748) NhaB PF06450.12 ETO24459.1 - 0.4 9.5 1.5 0.66 8.7 0.1 1.7 1 1 1 2 2 2 0 Bacterial Na+/H+ antiporter B (NhaB) U-box PF04564.15 ETO24461.1 - 1.2e-12 47.8 0.3 6.8e-12 45.4 0.0 2.5 3 0 0 3 3 3 1 U-box domain VWA PF00092.28 ETO24461.1 - 2.2e-07 31.3 0.0 2.9e-06 27.7 0.0 2.7 2 0 0 2 2 2 1 von Willebrand factor type A domain ubiquitin PF00240.23 ETO24461.1 - 0.0004 20.1 0.0 0.00099 18.8 0.0 1.7 1 0 0 1 1 1 1 Ubiquitin family Voldacs PF03517.13 ETO24461.1 - 0.57 10.3 8.0 3.8 7.6 0.1 3.0 3 0 0 3 3 3 0 Regulator of volume decrease after cellular swelling Kinesin PF00225.23 ETO24463.1 - 2.7e-59 200.8 1.5 5e-59 199.9 1.5 1.4 1 0 0 1 1 1 1 Kinesin motor domain UPF0449 PF15136.6 ETO24463.1 - 0.087 13.3 0.4 0.23 12.0 0.4 1.7 1 0 0 1 1 1 0 Uncharacterised protein family UPF0449 MIT PF04212.18 ETO24463.1 - 0.099 12.7 1.3 0.28 11.3 1.3 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Nodulin_late PF07127.11 ETO24463.1 - 1.8 9.0 8.6 3.5 8.0 0.2 3.5 3 0 0 3 3 3 0 Late nodulin protein DUF16 PF01519.16 ETO24463.1 - 4.5 7.8 8.2 0.38 11.3 0.9 2.8 3 0 0 3 3 3 0 Protein of unknown function DUF16 COG5 PF10392.9 ETO24463.1 - 5.3 7.2 14.8 2.3 8.4 2.2 3.9 4 0 0 4 4 4 0 Golgi transport complex subunit 5 Seryl_tRNA_N PF02403.22 ETO24463.1 - 5.7 7.2 12.3 1.3 9.3 8.1 2.0 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain DUF2956 PF11169.8 ETO24464.1 - 1.8 8.8 8.9 4.6 7.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) VWA_2 PF13519.6 ETO24466.1 - 7.6e-16 58.7 0.2 2.5e-15 57.0 0.1 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETO24466.1 - 7.8e-13 49.0 0.0 1.4e-12 48.2 0.0 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO24466.1 - 3.7e-06 27.0 0.3 9.9e-06 25.6 0.3 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain vWA-TerF-like PF10138.9 ETO24466.1 - 0.0003 20.9 0.0 0.00079 19.6 0.0 1.7 2 0 0 2 2 2 1 vWA found in TerF C terminus VWA_CoxE PF05762.14 ETO24466.1 - 0.025 14.0 0.1 0.086 12.2 0.0 1.9 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein Kinesin PF00225.23 ETO24467.1 - 8.2e-09 34.8 0.6 9.4e-09 34.6 0.6 1.1 1 0 0 1 1 1 1 Kinesin motor domain Bac_DnaA_C PF08299.11 ETO24470.1 - 0.039 14.0 0.3 4 7.6 0.0 2.4 1 1 1 2 2 2 0 Bacterial dnaA protein helix-turn-helix Flavi_propep PF01570.17 ETO24470.1 - 0.077 13.0 0.8 0.21 11.6 0.8 1.8 1 0 0 1 1 1 0 Flavivirus polyprotein propeptide Ldt_C PF17969.1 ETO24470.1 - 7.9 7.3 7.4 14 6.5 0.2 3.5 2 1 1 4 4 4 0 L,D-transpeptidase C-terminal domain PAP2 PF01569.21 ETO24471.1 - 7.5e-16 58.1 5.5 7.5e-16 58.1 5.5 2.2 1 1 1 2 2 2 1 PAP2 superfamily DUF3043 PF11241.8 ETO24471.1 - 0.37 10.8 1.5 0.71 9.9 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3043) Pox_Ag35 PF03286.14 ETO24471.1 - 0.74 9.6 29.7 0.036 13.9 9.2 2.4 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Utp14 PF04615.13 ETO24471.1 - 2 6.9 30.1 2.8 6.4 30.1 1.2 1 0 0 1 1 1 0 Utp14 protein Caveolin PF01146.17 ETO24471.1 - 8.1 6.4 8.9 2.2 8.3 1.5 2.7 2 0 0 2 2 2 0 Caveolin DUF3807 PF12720.7 ETO24471.1 - 8.9 6.5 28.8 2.6 8.3 9.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3807) SDA1 PF05285.12 ETO24473.1 - 0.003 17.0 9.1 0.003 17.0 9.1 2.3 3 0 0 3 3 3 1 SDA1 BSP_II PF05432.11 ETO24473.1 - 0.0047 16.7 4.1 0.0047 16.7 4.1 2.1 2 0 0 2 2 2 2 Bone sialoprotein II (BSP-II) Paf1 PF03985.13 ETO24473.1 - 0.041 12.9 9.8 0.067 12.2 9.8 1.3 1 0 0 1 1 1 0 Paf1 DUF2052 PF09747.9 ETO24473.1 - 0.2 11.8 12.3 0.1 12.7 8.5 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) Sin3_corepress PF08295.12 ETO24474.1 - 3.1e-13 49.6 1.1 8.3e-13 48.2 0.1 2.0 2 0 0 2 2 2 1 Sin3 family co-repressor Prion PF00377.18 ETO24474.1 - 0.061 13.2 0.8 0.07 13.0 0.0 1.5 2 0 0 2 2 2 0 Prion/Doppel alpha-helical domain DUF1989 PF09347.10 ETO24475.1 - 0.18 11.4 0.0 4.9 6.8 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1989) WD40_4 PF16300.5 ETO24477.1 - 2.8e-13 49.5 0.1 4.7e-13 48.8 0.1 1.4 1 0 0 1 1 1 1 Type of WD40 repeat DivIC PF04977.15 ETO24477.1 - 0.024 14.4 1.0 0.045 13.5 1.0 1.5 1 0 0 1 1 1 0 Septum formation initiator IFP_35_N PF07334.13 ETO24477.1 - 0.036 14.1 2.0 0.051 13.6 0.1 2.0 2 0 0 2 2 2 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus Phosphoprotein PF00922.17 ETO24477.1 - 0.047 13.3 0.8 0.066 12.8 0.8 1.2 1 0 0 1 1 1 0 Vesiculovirus phosphoprotein Cnn_1N PF07989.11 ETO24477.1 - 0.078 13.1 1.5 0.19 11.9 0.9 1.8 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 GP52 PF17468.2 ETO24477.1 - 0.13 12.4 0.0 0.26 11.5 0.0 1.4 1 0 0 1 1 1 0 Phage gene product 52 bZIP_2 PF07716.15 ETO24477.1 - 0.19 11.8 2.2 0.33 11.1 2.2 1.3 1 0 0 1 1 1 0 Basic region leucine zipper RPEL PF02755.15 ETO24478.1 - 0.017 14.8 4.6 2 8.2 0.0 3.4 3 0 0 3 3 3 0 RPEL repeat DUF2203 PF09969.9 ETO24478.1 - 0.054 14.2 6.5 0.43 11.3 1.6 2.5 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) BST2 PF16716.5 ETO24478.1 - 0.88 10.2 13.0 3.6 8.2 0.4 3.0 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 DUF4576 PF15144.6 ETO24478.1 - 6.7 6.7 6.2 22 5.0 0.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4576) RPEL PF02755.15 ETO24479.1 - 4.8e-06 26.1 8.9 0.017 14.8 0.2 3.6 3 0 0 3 3 3 2 RPEL repeat Herpes_BLRF2 PF05812.12 ETO24479.1 - 0.0021 18.2 0.9 0.24 11.6 0.1 2.6 2 0 0 2 2 2 1 Herpesvirus BLRF2 protein zf-C4H2 PF10146.9 ETO24479.1 - 0.012 15.9 2.0 0.012 15.9 2.0 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein Csm1_N PF18504.1 ETO24479.1 - 0.66 10.3 7.9 0.11 12.8 2.3 2.5 2 0 0 2 2 2 0 Csm1 N-terminal domain DUF1664 PF07889.12 ETO24479.1 - 0.8 9.7 5.6 7.8 6.6 0.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 ETO24479.1 - 1 9.6 14.2 0.071 13.3 5.1 2.9 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Fungal_TACC PF12709.7 ETO24479.1 - 2.4 8.7 8.8 1.4 9.4 1.7 3.5 3 1 1 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins GAS PF13851.6 ETO24479.1 - 3.9 6.8 21.0 0.23 10.8 7.3 2.6 2 2 0 2 2 2 0 Growth-arrest specific micro-tubule binding KxDL PF10241.9 ETO24479.1 - 5.1 7.4 10.8 2.7 8.3 2.9 2.8 2 0 0 2 2 2 0 Uncharacterized conserved protein Dsh_C PF12316.8 ETO24479.1 - 6.7 7.1 5.9 1.1 9.6 1.6 1.8 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal AXE1 PF05448.12 ETO24481.1 - 0.13 10.9 0.1 0.29 9.7 0.0 1.6 2 0 0 2 2 2 0 Acetyl xylan esterase (AXE1) DUF4770 PF15994.5 ETO24481.1 - 1 9.5 11.2 4.2 7.6 0.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) SDA1 PF05285.12 ETO24481.1 - 2.1 7.7 26.6 3 7.2 26.6 1.3 1 0 0 1 1 1 0 SDA1 BSMAP PF12280.8 ETO24482.1 - 5.4 7.2 6.3 0.27 11.4 0.7 1.7 2 1 0 2 2 2 0 Brain specific membrane anchored protein REJ PF02010.15 ETO24483.1 - 0.00018 20.5 1.0 0.00025 20.0 1.0 1.3 1 0 0 1 1 1 1 REJ domain CSG2 PF16965.5 ETO24484.1 - 0.04 12.9 3.4 0.034 13.1 0.9 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator Kei1 PF08552.11 ETO24484.1 - 0.085 12.7 0.1 0.19 11.6 0.1 1.6 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CLN3 PF02487.17 ETO24484.1 - 1 8.4 3.0 2.1 7.3 0.2 2.3 2 1 0 2 2 2 0 CLN3 protein Sulfotransfer_2 PF03567.14 ETO24485.1 - 5.3e-10 39.6 4.0 5.3e-10 39.6 4.0 2.0 2 1 0 2 2 2 1 Sulfotransferase family Peptidase_M24 PF00557.24 ETO24486.1 - 4.6e-07 29.7 0.2 5.7e-07 29.4 0.2 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 Ribosomal_L23 PF00276.20 ETO24487.1 - 0.0057 17.0 0.1 0.01 16.2 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L23 Nop14 PF04147.12 ETO24488.1 - 0.036 12.3 5.9 0.038 12.2 5.9 1.0 1 0 0 1 1 1 0 Nop14-like family Menin PF05053.13 ETO24488.1 - 0.18 10.1 7.1 0.22 9.9 7.1 1.0 1 0 0 1 1 1 0 Menin FAM176 PF14851.6 ETO24488.1 - 0.21 11.2 4.5 0.26 10.9 4.5 1.1 1 0 0 1 1 1 0 FAM176 family CDC45 PF02724.14 ETO24488.1 - 0.61 8.3 8.1 0.68 8.2 8.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO24488.1 - 4.9 5.8 7.4 5.2 5.7 7.4 1.1 1 0 0 1 1 1 0 Presenilin MFS_1 PF07690.16 ETO24489.1 - 3.5e-09 36.1 10.5 6.2e-09 35.2 10.5 1.4 1 1 0 1 1 1 1 Major Facilitator Superfamily FAM176 PF14851.6 ETO24489.1 - 0.21 11.2 2.5 0.68 9.6 2.6 1.7 1 1 0 1 1 1 0 FAM176 family Peptidase_M22 PF00814.25 ETO24491.1 - 0.054 13.2 0.0 0.62 9.7 0.0 2.1 2 0 0 2 2 2 0 Glycoprotease family Omp28 PF11551.8 ETO24491.1 - 0.46 10.3 2.1 0.39 10.5 0.4 1.7 2 0 0 2 2 2 0 Outer membrane protein Omp28 Myb_Cef PF11831.8 ETO24492.1 - 4.4e-27 95.2 13.7 9.4e-27 94.1 13.7 1.5 1 0 0 1 1 1 1 pre-mRNA splicing factor component DUF4474 PF14751.6 ETO24492.1 - 0.047 13.1 1.3 0.086 12.2 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4474) RdRP PF05183.12 ETO24493.1 - 3.7e-29 101.8 0.1 5.5e-29 101.3 0.1 1.2 1 0 0 1 1 1 1 RNA dependent RNA polymerase RRM_1 PF00076.22 ETO24493.1 - 0.014 15.2 0.0 0.036 13.9 0.0 1.7 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RdRP PF05183.12 ETO24494.1 - 6.5e-61 206.7 0.1 7.7e-61 206.5 0.1 1.0 1 0 0 1 1 1 1 RNA dependent RNA polymerase RdRP PF05183.12 ETO24495.1 - 2.5e-13 49.5 0.0 4.1e-13 48.8 0.0 1.4 1 0 0 1 1 1 1 RNA dependent RNA polymerase NAP PF00956.18 ETO24495.1 - 0.0065 15.7 0.7 0.013 14.7 0.7 1.4 1 0 0 1 1 1 1 Nucleosome assembly protein (NAP) DUF3135 PF11333.8 ETO24495.1 - 0.1 12.9 2.0 0.18 12.1 0.1 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3135) WD40 PF00400.32 ETO24496.1 - 7.2e-64 210.2 22.3 1.7e-09 38.2 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24496.1 - 8.2e-21 74.1 1.6 0.023 15.0 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24496.1 - 3e-15 56.0 0.6 0.0057 15.7 0.1 6.8 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO24496.1 - 3.9e-06 26.7 9.6 1.1 9.3 0.0 6.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO24496.1 - 5.6e-06 25.1 1.4 0.024 13.2 0.1 2.7 2 1 0 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO24496.1 - 7.5e-06 25.5 0.1 0.036 13.4 0.0 2.6 2 0 0 2 2 2 2 WD40-like domain Nbas_N PF15492.6 ETO24496.1 - 0.0084 15.5 1.9 0.41 9.9 0.0 3.2 1 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal SGL PF08450.12 ETO24496.1 - 0.0085 15.7 0.1 0.38 10.3 0.0 2.6 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Proteasome_A_N PF10584.9 ETO24496.1 - 7.7 6.3 0.0 7.7 6.3 0.0 4.9 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature NUC130_3NT PF08158.12 ETO24497.1 - 0.061 13.7 0.0 1.6 9.1 0.0 2.3 2 0 0 2 2 2 0 NUC130/3NT domain Pkinase PF00069.25 ETO24498.1 - 5.8e-19 68.5 0.0 9.2e-15 54.7 0.0 3.1 2 1 0 2 2 2 2 Protein kinase domain SDA1 PF05285.12 ETO24498.1 - 0.003 17.0 13.3 0.003 17.0 13.3 1.6 2 0 0 2 2 2 1 SDA1 CDC45 PF02724.14 ETO24498.1 - 0.003 15.9 7.4 0.0033 15.8 7.4 1.1 1 0 0 1 1 1 1 CDC45-like protein Pkinase_Tyr PF07714.17 ETO24498.1 - 0.0035 16.7 0.1 1.7 7.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Sporozoite_P67 PF05642.11 ETO24498.1 - 0.036 12.2 9.5 0.048 11.8 9.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NPR3 PF03666.13 ETO24498.1 - 0.07 11.9 4.7 0.075 11.8 4.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.12 ETO24498.1 - 0.15 10.2 21.5 0.2 9.8 21.5 1.1 1 0 0 1 1 1 0 Nop14-like family Orthopox_F8 PF05886.11 ETO24498.1 - 0.16 12.1 0.6 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 Orthopoxvirus F8 protein Presenilin PF01080.17 ETO24498.1 - 0.67 8.7 4.3 0.82 8.4 4.3 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO24498.1 - 2.6 7.2 7.1 3.6 6.7 7.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2457 PF10446.9 ETO24498.1 - 8.1 5.5 27.0 13 4.8 27.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PA28_beta PF02252.18 ETO24500.1 - 2e-25 89.1 0.1 2e-25 89.1 0.1 2.0 2 0 0 2 2 2 1 Proteasome activator pa28 beta subunit PA28_alpha PF02251.18 ETO24500.1 - 0.00011 22.1 5.7 0.00057 19.9 5.7 2.3 1 0 0 1 1 1 1 Proteasome activator pa28 alpha subunit DUF4279 PF14106.6 ETO24500.1 - 0.0088 16.2 1.1 0.018 15.3 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4279) Phage_ABA_S PF18066.1 ETO24500.1 - 0.064 14.0 0.3 0.26 12.0 0.0 2.1 2 0 0 2 2 2 0 Phage ABA sandwich domain GlutR_dimer PF00745.20 ETO24500.1 - 0.28 11.7 3.5 4.8 7.7 0.1 2.5 1 1 0 2 2 2 0 Glutamyl-tRNAGlu reductase, dimerisation domain Cyt_b-c1_8 PF10890.8 ETO24500.1 - 0.35 11.3 1.7 0.45 11.0 0.0 2.0 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 PMM PF03332.13 ETO24501.1 - 1.2e-84 283.5 2.5 1.5e-84 283.2 2.5 1.1 1 0 0 1 1 1 1 Eukaryotic phosphomannomutase Hydrolase_3 PF08282.12 ETO24501.1 - 0.00012 22.0 0.0 0.00084 19.2 0.0 2.1 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase S6PP PF05116.13 ETO24501.1 - 0.1 12.1 0.0 14 5.1 0.0 2.1 2 0 0 2 2 2 0 Sucrose-6F-phosphate phosphohydrolase Vps35 PF03635.17 ETO24502.1 - 2.8e-36 125.3 0.0 3.3e-36 125.1 0.0 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 35 IBR PF01485.21 ETO24503.1 - 1.1e-10 41.5 61.4 3e-07 30.5 10.5 4.4 3 1 1 4 4 4 2 IBR domain, a half RING-finger domain zf-RING_2 PF13639.6 ETO24503.1 - 0.00049 20.4 10.1 0.00049 20.4 10.1 3.9 2 1 1 3 3 3 2 Ring finger domain zf-C3HC4_2 PF13923.6 ETO24503.1 - 0.0016 18.3 5.2 0.0016 18.3 5.2 4.6 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO24503.1 - 0.0068 16.3 10.1 0.0068 16.3 10.1 5.0 3 2 1 4 4 4 1 Zinc finger, C3HC4 type (RING finger) TrmK PF04816.12 ETO24503.1 - 1.1 8.7 6.0 2.8 7.4 6.0 1.6 1 0 0 1 1 1 0 tRNA (adenine(22)-N(1))-methyltransferase SUIM_assoc PF16619.5 ETO24504.1 - 0.0018 18.3 6.3 0.047 13.8 0.9 2.6 2 0 0 2 2 2 2 Unstructured region C-term to UIM in Ataxin3 Acetyltransf_13 PF13880.6 ETO24504.1 - 0.069 13.1 0.0 0.17 11.9 0.0 1.7 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase Peptidase_C23 PF05379.11 ETO24504.1 - 0.17 12.0 0.1 0.64 10.2 0.0 2.0 2 0 0 2 2 2 0 Carlavirus endopeptidase Phostensin_N PF13916.6 ETO24504.1 - 7.2 7.0 8.1 4.7 7.6 0.5 2.4 2 0 0 2 2 2 0 PP1-regulatory protein, Phostensin N-terminal zf-C3HC4_3 PF13920.6 ETO24505.1 - 0.19 11.6 7.3 0.5 10.3 7.3 1.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO24505.1 - 4.6 7.6 12.3 0.73 10.2 5.5 2.3 1 1 1 2 2 2 0 RING-like domain PSI_PsaJ PF01701.18 ETO24507.1 - 0.0045 17.5 1.4 0.0045 17.5 1.4 2.0 2 0 0 2 2 2 1 Photosystem I reaction centre subunit IX / PsaJ PHD_Oberon PF07227.11 ETO24507.1 - 0.15 12.0 3.5 0.2 11.5 3.5 1.2 1 0 0 1 1 1 0 PHD - plant homeodomain finger protein WBP-1 PF11669.8 ETO24507.1 - 0.26 12.0 6.1 0.67 10.6 6.1 1.6 1 0 0 1 1 1 0 WW domain-binding protein 1 SIR2 PF02146.17 ETO24509.1 - 0.009 16.0 0.1 0.013 15.5 0.1 1.1 1 0 0 1 1 1 1 Sir2 family HSP70 PF00012.20 ETO24511.1 - 9.2e-15 53.8 1.1 9.2e-15 53.8 1.1 4.0 2 2 2 4 4 4 1 Hsp70 protein MMR_HSR1 PF01926.23 ETO24511.1 - 3.5e-05 23.9 0.4 0.00029 20.9 0.1 2.8 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_22 PF13401.6 ETO24511.1 - 0.015 15.6 0.8 0.099 12.9 0.0 2.8 4 0 0 4 4 4 0 AAA domain CHIP_TPR_N PF18391.1 ETO24511.1 - 0.026 15.3 7.2 0.026 15.3 7.2 3.8 4 1 1 5 5 3 0 CHIP N-terminal tetratricopeptide repeat domain T2SSE PF00437.20 ETO24511.1 - 0.042 12.9 0.1 0.099 11.7 0.1 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_16 PF13191.6 ETO24511.1 - 0.053 13.9 0.5 0.23 11.8 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain TA_inhibitor PF17574.2 ETO24511.1 - 0.057 13.5 0.2 0.18 11.9 0.2 1.9 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) AAA_29 PF13555.6 ETO24511.1 - 0.091 12.5 0.0 0.27 11.0 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_5 PF07728.14 ETO24511.1 - 0.1 12.6 0.0 0.32 11.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO24511.1 - 0.13 12.8 0.0 0.13 12.8 0.0 3.4 4 0 0 4 4 4 0 ABC transporter Gtr1_RagA PF04670.12 ETO24511.1 - 0.16 11.3 0.0 0.16 11.3 0.0 3.0 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region AAA PF00004.29 ETO24511.1 - 0.28 11.6 2.3 3 8.3 0.0 3.8 4 1 0 4 4 4 0 ATPase family associated with various cellular activities (AAA) DUF1266 PF06889.11 ETO24511.1 - 5.2 7.1 7.5 1.5 8.8 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1266) DUF2428 PF10350.9 ETO24513.1 - 0.14 11.4 0.8 0.3 10.3 0.8 1.7 1 1 0 1 1 1 0 Putative death-receptor fusion protein (DUF2428) BRCA-2_OB3 PF09104.10 ETO24514.1 - 0.056 13.1 0.9 0.49 10.0 0.1 2.5 2 0 0 2 2 2 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 Peroxin-13_N PF04088.13 ETO24514.1 - 0.17 12.2 7.9 2 8.7 1.3 3.1 3 0 0 3 3 3 0 Peroxin 13, N-terminal region Vma12 PF11712.8 ETO24514.1 - 1.7 8.7 7.2 0.22 11.6 2.4 2.0 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase EIIBC-GUT_N PF03612.14 ETO24514.1 - 2 8.2 11.0 0.19 11.4 1.0 2.6 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus EMC3_TMCO1 PF01956.16 ETO24514.1 - 4.9 6.9 5.8 10 5.8 1.1 3.0 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like C2 PF00168.30 ETO24515.1 - 1e-09 38.6 0.1 1.6e-09 38.0 0.1 1.3 1 0 0 1 1 1 1 C2 domain FlgD_ig PF13860.6 ETO24515.1 - 0.058 13.3 0.3 0.12 12.3 0.3 1.4 1 0 0 1 1 1 0 FlgD Ig-like domain TMEM213 PF15192.6 ETO24516.1 - 0.021 14.8 0.2 0.058 13.4 0.2 1.7 1 0 0 1 1 1 0 TMEM213 family HEAT PF02985.22 ETO24516.1 - 0.04 14.2 0.0 70 4.1 0.0 4.3 4 0 0 4 4 4 0 HEAT repeat RPEL PF02755.15 ETO24518.1 - 0.0014 18.3 0.0 0.0014 18.3 0.0 2.4 2 0 0 2 2 2 1 RPEL repeat CDC45 PF02724.14 ETO24518.1 - 0.003 15.9 14.4 0.0032 15.9 14.4 1.1 1 0 0 1 1 1 1 CDC45-like protein DUF5523 PF17661.1 ETO24518.1 - 0.0033 17.2 19.7 0.0037 17.0 19.7 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5523) Merozoite_SPAM PF07133.11 ETO24518.1 - 0.0036 17.3 28.3 0.0055 16.7 28.3 1.2 1 0 0 1 1 1 1 Merozoite surface protein (SPAM) BUD22 PF09073.10 ETO24518.1 - 0.0037 16.7 13.9 0.0048 16.3 13.9 1.2 1 0 0 1 1 1 1 BUD22 Drc1-Sld2 PF11719.8 ETO24518.1 - 0.015 14.9 13.7 0.015 14.9 13.7 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein RR_TM4-6 PF06459.12 ETO24518.1 - 0.016 15.1 12.1 0.02 14.8 12.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 RNA_polI_A34 PF08208.11 ETO24518.1 - 0.019 15.1 19.1 0.023 14.8 19.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 PTPRCAP PF15713.5 ETO24518.1 - 0.039 14.2 12.9 0.055 13.8 12.9 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated YqfQ PF14181.6 ETO24518.1 - 0.043 14.0 10.1 0.059 13.6 10.1 1.3 1 0 0 1 1 1 0 YqfQ-like protein DUF4776 PF16003.5 ETO24518.1 - 0.063 12.3 12.5 0.067 12.2 12.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) DUF913 PF06025.12 ETO24518.1 - 0.11 11.5 6.5 0.11 11.4 6.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 ETO24518.1 - 0.11 11.0 12.8 0.14 10.7 12.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Connexin PF00029.19 ETO24518.1 - 0.13 12.0 8.2 0.16 11.7 8.2 1.2 1 0 0 1 1 1 0 Connexin DDHD PF02862.17 ETO24518.1 - 0.16 12.1 6.0 0.18 12.0 6.0 1.2 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.14 ETO24518.1 - 0.19 12.2 9.2 0.26 11.7 9.2 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF3381 PF11861.8 ETO24518.1 - 0.23 11.2 26.2 0.45 10.3 26.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) CobT PF06213.12 ETO24518.1 - 0.33 10.3 16.3 0.45 9.9 16.3 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT PMSI1 PF15322.6 ETO24518.1 - 0.37 10.2 6.3 0.51 9.7 6.3 1.3 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative GAGA_bind PF06217.12 ETO24518.1 - 0.38 11.0 8.7 0.38 11.0 8.7 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Peptidase_S64 PF08192.11 ETO24518.1 - 0.4 9.1 10.1 0.48 8.9 10.1 1.0 1 0 0 1 1 1 0 Peptidase family S64 TFIIF_alpha PF05793.12 ETO24518.1 - 0.41 9.2 27.3 0.52 8.8 27.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) AAA_11 PF13086.6 ETO24518.1 - 0.61 9.8 10.3 0.69 9.6 10.3 1.2 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 ETO24518.1 - 0.62 8.8 8.1 0.64 8.7 8.1 1.2 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 ETO24518.1 - 0.81 9.4 4.9 1.2 8.8 4.9 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus SLC12 PF03522.15 ETO24518.1 - 1.5 7.8 13.9 1.7 7.5 13.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Paf1 PF03985.13 ETO24518.1 - 1.5 7.7 24.5 2.1 7.3 24.5 1.2 1 0 0 1 1 1 0 Paf1 CLN3 PF02487.17 ETO24518.1 - 2.2 7.3 5.1 2.3 7.2 5.1 1.2 1 0 0 1 1 1 0 CLN3 protein TRAP_alpha PF03896.16 ETO24518.1 - 2.8 7.1 10.2 4 6.6 10.2 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.22 ETO24518.1 - 5.3 6.2 8.2 6.3 5.9 8.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO24518.1 - 5.8 6.9 7.2 7.1 6.6 7.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF1682 PF07946.14 ETO24518.1 - 6 6.0 23.1 7.8 5.6 23.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) Sec62 PF03839.16 ETO24518.1 - 6.3 6.3 14.9 8 5.9 14.9 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 MscS_TM PF12794.7 ETO24518.1 - 6.7 5.5 5.5 9.7 4.9 5.5 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 ALMT PF11744.8 ETO24518.1 - 7.5 5.3 10.8 7.7 5.2 10.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter GNAT_acetyltr_2 PF13718.6 ETO24518.1 - 8.7 5.7 10.5 15 4.9 10.5 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase 2 MDM10 PF12519.8 ETO24518.1 - 9.2 5.0 9.0 10 4.9 9.0 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DUF2828 PF11443.8 ETO24520.1 - 0.0052 14.9 6.9 0.0061 14.7 6.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF2828) RR_TM4-6 PF06459.12 ETO24520.1 - 0.061 13.2 13.2 0.093 12.6 13.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 ETO24520.1 - 0.3 11.2 5.2 0.54 10.4 5.2 1.5 1 0 0 1 1 1 0 DDHD domain XRN_M PF17846.1 ETO24520.1 - 0.43 9.5 9.6 0.62 9.0 9.6 1.2 1 0 0 1 1 1 0 Xrn1 helical domain RPN2_C PF18004.1 ETO24520.1 - 0.59 10.0 17.5 1.2 9.1 17.5 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Striatin PF08232.12 ETO24520.1 - 0.71 10.5 19.1 1.2 9.8 19.1 1.3 1 0 0 1 1 1 0 Striatin family Neur_chan_memb PF02932.16 ETO24520.1 - 2.6 8.0 4.3 4.4 7.3 4.3 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Afi1 PF07792.12 ETO24520.1 - 2.7 8.5 12.5 11 6.5 11.4 2.2 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_Rpc4 PF05132.14 ETO24520.1 - 3.8 7.9 10.4 6.4 7.2 10.4 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Vfa1 PF08432.10 ETO24520.1 - 6.7 7.0 24.5 12 6.1 24.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RasGEF PF00617.19 ETO24521.1 - 2.7e-11 44.0 3.0 2.7e-11 44.0 3.0 2.9 3 0 0 3 3 3 2 RasGEF domain HTH_ParB PF17762.1 ETO24521.1 - 0.012 15.4 0.0 0.038 13.8 0.0 1.9 1 0 0 1 1 1 0 HTH domain found in ParB protein Ribosomal_L35Ae PF01247.18 ETO24523.1 - 0.02 15.0 1.1 0.034 14.3 0.8 1.6 2 0 0 2 2 2 0 Ribosomal protein L35Ae PI3_PI4_kinase PF00454.27 ETO24525.1 - 1.7e-50 172.2 0.1 3.8e-50 171.0 0.0 1.6 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ETO24525.1 - 1.7e-14 53.3 0.7 6e-14 51.6 0.7 2.0 1 0 0 1 1 1 1 FATC domain DUF3150 PF11348.8 ETO24525.1 - 0.086 12.1 0.1 0.16 11.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) CCM2_C PF16545.5 ETO24525.1 - 0.099 13.2 0.2 0.65 10.6 0.0 2.2 2 0 0 2 2 2 0 Cerebral cavernous malformation protein, harmonin-homology SecY PF00344.20 ETO24527.1 - 9.5 5.4 14.3 43 3.2 14.3 2.2 1 1 0 1 1 1 0 SecY translocase Pkinase PF00069.25 ETO24530.1 - 3.1e-66 223.4 0.0 4.6e-66 222.9 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24530.1 - 5.1e-27 94.8 0.0 8.1e-27 94.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO24530.1 - 3.3e-05 23.4 0.1 0.0032 16.8 0.0 2.5 1 1 0 2 2 2 1 Kinase-like cNMP_binding PF00027.29 ETO24530.1 - 0.00035 20.6 0.8 1.9 8.6 0.0 3.3 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain AAA_14 PF13173.6 ETO24530.1 - 0.14 12.2 0.6 0.41 10.7 0.6 1.8 1 0 0 1 1 1 0 AAA domain Secretin_N_2 PF07655.13 ETO24530.1 - 8.6 7.0 11.1 5.2 7.7 8.3 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain UNC-50 PF05216.13 ETO24531.1 - 1.3e-19 70.7 14.0 1.3e-19 70.7 14.0 1.7 1 1 1 2 2 2 1 UNC-50 family Glyco_hydro_76 PF03663.14 ETO24533.1 - 4.9e-19 69.1 6.7 6e-19 68.8 6.7 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 76 RasGEF_N PF00618.20 ETO24534.1 - 0.12 12.6 12.4 0.37 11.1 11.7 2.2 1 1 0 1 1 1 0 RasGEF N-terminal motif Secretin_N_2 PF07655.13 ETO24534.1 - 4.6 7.8 15.9 0.18 12.4 2.7 3.2 3 0 0 3 3 3 0 Secretin N-terminal domain YajC PF02699.15 ETO24538.1 - 0.089 12.7 0.1 0.94 9.4 0.0 2.3 2 0 0 2 2 2 0 Preprotein translocase subunit Peptidase_S46 PF10459.9 ETO24541.1 - 0.13 10.9 13.2 0.22 10.1 13.2 1.3 1 0 0 1 1 1 0 Peptidase S46 FdhD-NarQ PF02634.15 ETO24541.1 - 0.39 10.3 3.7 0.7 9.5 0.2 2.2 2 0 0 2 2 2 0 FdhD/NarQ family EHN PF06441.12 ETO24541.1 - 0.82 10.1 4.4 0.78 10.1 1.1 2.5 1 1 1 2 2 2 0 Epoxide hydrolase N terminus Csm1_N PF18504.1 ETO24541.1 - 1.3 9.5 17.5 1.5 9.2 2.3 3.8 2 1 1 3 3 3 0 Csm1 N-terminal domain Rootletin PF15035.6 ETO24541.1 - 4.7 7.2 24.7 1 9.3 9.6 3.6 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion bZIP_1 PF00170.21 ETO24541.1 - 8.8 6.5 19.2 0.11 12.6 3.8 4.0 2 2 1 3 3 3 0 bZIP transcription factor DUF4094 PF13334.6 ETO24542.1 - 0.027 14.9 1.0 0.027 14.9 1.0 2.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4094) FlaC_arch PF05377.11 ETO24542.1 - 0.079 13.4 2.6 0.28 11.6 2.6 1.9 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) Cep57_CLD_2 PF14197.6 ETO24542.1 - 0.18 11.9 7.0 0.42 10.7 7.0 1.7 1 0 0 1 1 1 0 Centrosome localisation domain of PPC89 bZIP_1 PF00170.21 ETO24542.1 - 3.9 7.6 9.9 0.64 10.2 5.8 1.8 2 0 0 2 2 2 0 bZIP transcription factor Beta_helix PF13229.6 ETO24543.1 - 0.0041 17.0 1.6 0.0048 16.8 0.3 1.8 1 1 1 2 2 2 1 Right handed beta helix region Peptidase_S10 PF00450.22 ETO24544.1 - 4.5e-16 59.3 0.0 5.2e-11 42.6 0.0 2.2 2 0 0 2 2 2 2 Serine carboxypeptidase ubiquitin PF00240.23 ETO24545.1 - 7.6e-08 32.0 0.0 1.6e-07 31.0 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin family Filament PF00038.21 ETO24546.1 - 0.013 15.1 6.6 0.018 14.6 6.6 1.2 1 0 0 1 1 1 0 Intermediate filament protein YqaJ PF09588.10 ETO24546.1 - 0.016 15.4 0.2 0.02 15.0 0.2 1.2 1 0 0 1 1 1 0 YqaJ-like viral recombinase domain PNMA PF14893.6 ETO24546.1 - 0.023 14.1 0.7 0.025 14.0 0.7 1.0 1 0 0 1 1 1 0 PNMA Laminin_I PF06008.14 ETO24546.1 - 0.031 14.0 7.0 0.036 13.8 1.8 1.9 1 1 1 2 2 2 0 Laminin Domain I DASH_Dad1 PF08649.10 ETO24546.1 - 0.043 14.0 0.6 0.043 14.0 0.6 2.7 3 1 1 4 4 4 0 DASH complex subunit Dad1 BLOC1_2 PF10046.9 ETO24546.1 - 0.048 14.0 0.5 0.048 14.0 0.5 2.4 1 1 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 T3SSipB PF16535.5 ETO24546.1 - 0.05 14.1 2.6 0.079 13.4 2.6 1.3 1 0 0 1 1 1 0 Type III cell invasion protein SipB Cob_adeno_trans PF01923.18 ETO24546.1 - 0.056 13.6 1.2 0.079 13.1 1.1 1.3 1 1 0 1 1 1 0 Cobalamin adenosyltransferase DUF948 PF06103.11 ETO24546.1 - 0.083 13.2 0.9 0.17 12.1 0.4 1.8 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) FAM76 PF16046.5 ETO24546.1 - 0.12 11.8 4.4 0.065 12.6 2.8 1.4 1 1 0 1 1 1 0 FAM76 protein DUF2524 PF10732.9 ETO24546.1 - 0.16 12.3 5.4 0.12 12.7 3.5 1.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2524) TMPIT PF07851.13 ETO24546.1 - 0.17 11.1 6.1 0.21 10.8 6.1 1.1 1 0 0 1 1 1 0 TMPIT-like protein KELK PF15796.5 ETO24546.1 - 0.51 10.8 5.4 0.3 11.6 3.2 1.7 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF1664 PF07889.12 ETO24546.1 - 1.2 9.2 6.0 2.8 8.0 0.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) zf-C4H2 PF10146.9 ETO24546.1 - 1.6 9.0 6.3 0.62 10.3 2.1 1.8 1 1 1 2 2 2 0 Zinc finger-containing protein Antifungal_prot PF11402.8 ETO24547.1 - 1.6 9.0 12.5 0.17 12.2 6.7 2.2 2 0 0 2 2 2 0 Antifungal protein zf_CCCH_4 PF18345.1 ETO24547.1 - 2.5 8.3 0.0 2.5 8.3 0.0 4.7 3 1 0 3 3 3 0 Zinc finger domain Pirin_C PF05726.13 ETO24548.1 - 0.02 15.2 0.5 0.066 13.6 0.0 2.0 2 0 0 2 2 2 0 Pirin C-terminal cupin domain TPR_MLP1_2 PF07926.12 ETO24548.1 - 0.022 14.8 6.3 0.022 14.8 6.3 2.5 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein GTP-bdg_M PF16360.5 ETO24548.1 - 2.8 8.6 7.0 0.31 11.7 1.3 2.3 1 1 2 3 3 3 0 GTP-binding GTPase Middle Region TPR_12 PF13424.6 ETO24549.1 - 7.1e-47 157.6 12.4 1.4e-15 57.3 0.7 4.7 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24549.1 - 6.5e-34 114.9 0.8 2.4e-07 30.4 0.0 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24549.1 - 3.4e-32 108.9 29.0 1.4e-08 34.1 0.5 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24549.1 - 1.8e-23 80.7 20.6 2.1e-06 27.4 0.3 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24549.1 - 1.4e-20 71.7 9.1 0.00047 20.0 0.1 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24549.1 - 3.6e-19 67.3 30.2 8.8e-05 22.4 1.5 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat MIT PF04212.18 ETO24549.1 - 9.6e-10 38.4 18.0 0.0079 16.2 0.2 6.1 3 2 2 5 5 5 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO24549.1 - 1.2e-08 35.0 10.7 0.46 11.2 0.2 6.6 6 1 0 6 6 6 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO24549.1 - 6e-08 32.7 15.3 3.7e-05 23.6 3.2 3.5 1 1 1 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) TPR_16 PF13432.6 ETO24549.1 - 4.1e-07 30.6 0.0 0.31 11.7 0.0 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO24549.1 - 1.3e-06 28.6 0.1 3.1e-06 27.3 0.1 1.6 1 0 0 1 1 1 1 Caspase domain TPR_17 PF13431.6 ETO24549.1 - 6.2e-06 26.2 8.4 1.5 9.4 0.1 5.3 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24549.1 - 8.6e-06 26.2 0.0 3.4 8.7 0.0 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO24549.1 - 0.0051 16.2 0.9 2.3 7.7 0.0 3.8 4 0 0 4 4 4 1 SHNi-TPR TPR_11 PF13414.6 ETO24549.1 - 0.024 14.3 25.5 0.024 14.3 1.0 6.7 7 2 2 9 9 8 0 TPR repeat PPR PF01535.20 ETO24549.1 - 0.028 14.7 0.8 13 6.3 0.1 4.4 4 0 0 4 4 3 0 PPR repeat Prefoldin PF02996.17 ETO24549.1 - 0.041 13.8 6.5 0.11 12.4 0.8 3.7 3 1 0 3 3 3 0 Prefoldin subunit NRBF2_MIT PF17169.4 ETO24549.1 - 0.054 13.7 0.1 1.2 9.4 0.0 2.9 2 1 1 3 3 3 0 MIT domain of nuclear receptor-binding factor 2 DUF5344 PF17279.2 ETO24549.1 - 0.11 13.0 1.5 0.53 10.9 0.0 2.9 3 0 0 3 3 2 0 Family of unknown function (DUF5344) TPR_3 PF07720.12 ETO24549.1 - 0.13 12.3 20.1 0.082 12.9 2.9 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Mob_Pre PF01076.19 ETO24549.1 - 0.41 10.5 7.7 0.039 13.8 1.7 2.4 3 0 0 3 3 2 0 Plasmid recombination enzyme ANAPC3 PF12895.7 ETO24549.1 - 0.45 10.8 15.9 0.6 10.4 0.5 4.0 3 1 1 4 4 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Sel1 PF08238.12 ETO24549.1 - 0.52 11.1 11.2 1.2e+02 3.6 0.0 5.5 5 0 0 5 5 5 0 Sel1 repeat RPN7 PF10602.9 ETO24549.1 - 0.83 9.3 8.4 0.94 9.2 0.6 4.1 1 1 2 4 4 4 0 26S proteasome subunit RPN7 SPO22 PF08631.10 ETO24549.1 - 3 7.2 13.3 0.6 9.5 0.7 3.7 3 1 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like WD40 PF00400.32 ETO24550.1 - 1.7e-121 392.6 61.0 3.5e-09 37.1 0.6 16.7 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24550.1 - 3.7e-25 88.0 14.2 0.035 14.4 0.0 12.2 1 1 10 12 12 12 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24550.1 - 1.9e-16 60.0 8.8 0.42 9.5 0.0 11.4 3 2 9 13 13 13 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO24550.1 - 4.4e-11 42.1 32.4 0.03 13.0 0.0 12.5 6 5 8 14 14 14 3 Nucleoporin Nup120/160 NACHT PF05729.12 ETO24550.1 - 9.7e-11 41.9 0.0 1.9e-10 40.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Str_synth PF03088.16 ETO24550.1 - 6.2e-10 39.1 2.6 0.82 9.8 0.0 9.0 9 2 2 11 11 9 2 Strictosidine synthase Pentapeptide PF00805.22 ETO24550.1 - 1.5e-06 27.7 0.6 3.3e-06 26.6 0.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO24550.1 - 0.0013 18.9 0.1 0.0045 17.1 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO24550.1 - 0.0018 16.9 2.6 2.6 6.5 0.0 4.8 3 2 1 5 5 5 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO24550.1 - 0.0021 18.0 12.2 27 4.8 0.0 7.3 8 0 0 8 8 7 0 WD40-like Beta Propeller Repeat AAA_22 PF13401.6 ETO24550.1 - 0.0033 17.7 0.0 0.013 15.8 0.0 2.1 1 1 0 1 1 1 1 AAA domain AAA PF00004.29 ETO24550.1 - 0.0085 16.5 0.1 0.095 13.1 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Pentapeptide_3 PF13576.6 ETO24550.1 - 0.013 15.7 0.3 0.031 14.4 0.3 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO24550.1 - 0.02 15.5 0.0 0.02 15.5 0.0 3.8 4 0 0 4 4 3 0 AAA domain YfcL PF08891.11 ETO24550.1 - 0.029 14.7 0.9 11 6.5 0.2 3.2 2 0 0 2 2 2 0 YfcL protein RNA_helicase PF00910.22 ETO24550.1 - 0.046 14.1 1.7 0.75 10.2 0.0 3.9 3 1 0 3 3 3 0 RNA helicase AAA_16 PF13191.6 ETO24550.1 - 0.06 13.7 0.0 0.39 11.1 0.0 2.3 1 1 0 1 1 1 0 AAA ATPase domain Mst1_SARAH PF11629.8 ETO24550.1 - 0.078 13.1 1.7 0.38 10.9 0.4 2.9 2 0 0 2 2 2 0 C terminal SARAH domain of Mst1 BSD PF03909.17 ETO24550.1 - 0.16 12.0 2.0 5.1 7.2 0.1 3.7 3 0 0 3 3 3 0 BSD domain ABC_tran PF00005.27 ETO24550.1 - 0.7 10.4 0.0 0.7 10.4 0.0 3.2 3 0 0 3 3 2 0 ABC transporter Arf PF00025.21 ETO24551.1 - 1.2e-10 41.1 2.3 1.2e-07 31.3 0.1 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family TRAP_alpha PF03896.16 ETO24551.1 - 0.043 13.0 0.1 0.043 13.0 0.1 2.2 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit FANCD2OS PF15124.6 ETO24551.1 - 3.8 7.7 5.4 23 5.1 0.0 2.9 1 1 2 3 3 3 0 FANCD2 opposite strand protein CdvA PF18822.1 ETO24557.1 - 0.023 14.5 17.7 0.06 13.2 7.6 2.6 3 0 0 3 3 3 0 CdvA-like coiled-coil domain DUF3086 PF11285.8 ETO24557.1 - 3.3 6.7 10.2 1.4 7.9 6.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3086) DEAD PF00270.29 ETO24559.1 - 6.5e-07 29.3 0.0 1.1e-06 28.6 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO24559.1 - 0.081 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit AAA_25 PF13481.6 ETO24559.1 - 0.11 12.1 0.0 0.19 11.3 0.0 1.3 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO24559.1 - 0.15 11.5 0.0 0.22 11.0 0.0 1.2 1 0 0 1 1 1 0 PhoH-like protein AAA_18 PF13238.6 ETO24559.1 - 0.15 12.7 0.0 0.33 11.5 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ETO24559.1 - 0.18 11.6 0.0 0.31 10.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain DUF2207 PF09972.9 ETO24561.1 - 0.016 14.0 0.6 0.25 10.1 0.0 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) NOA36 PF06524.12 ETO24561.1 - 3.9 6.7 7.5 9.7 5.4 7.5 1.6 1 0 0 1 1 1 0 NOA36 protein MRG PF05712.13 ETO24562.1 - 0.00017 21.0 3.1 0.00042 19.7 3.1 1.7 1 1 0 1 1 1 1 MRG Cut8 PF08559.10 ETO24562.1 - 0.0055 16.3 0.2 0.0055 16.3 0.2 2.3 2 0 0 2 2 2 1 Cut8, nuclear proteasome tether protein Speriolin_N PF15058.6 ETO24565.1 - 0.0016 18.5 2.3 0.0022 18.1 2.3 1.4 1 0 0 1 1 1 1 Speriolin N terminus ZapB PF06005.12 ETO24565.1 - 0.0071 16.8 12.2 0.0071 16.8 12.2 3.0 2 1 1 3 3 3 1 Cell division protein ZapB DivIC PF04977.15 ETO24565.1 - 0.026 14.3 8.4 0.026 14.3 8.4 2.7 3 1 0 3 3 3 0 Septum formation initiator HALZ PF02183.18 ETO24565.1 - 0.53 10.6 15.1 0.43 10.8 9.0 3.1 2 1 1 3 3 3 0 Homeobox associated leucine zipper V_ATPase_I PF01496.19 ETO24565.1 - 1.5 6.6 14.5 1.7 6.5 14.5 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family JAKMIP_CC3 PF16034.5 ETO24565.1 - 2 8.3 19.0 6.4 6.7 19.0 1.9 1 1 0 1 1 1 0 JAKMIP CC3 domain DUF4140 PF13600.6 ETO24565.1 - 9.4 6.7 7.8 2.3 8.7 3.9 1.9 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) APG9 PF04109.16 ETO24567.1 - 1.7e-107 360.4 16.5 3.3e-52 178.1 4.4 4.0 3 1 0 3 3 3 3 Autophagy protein Apg9 BUD22 PF09073.10 ETO24567.1 - 0.0018 17.7 18.1 0.0018 17.7 18.1 3.2 3 0 0 3 3 3 2 BUD22 HCO3_cotransp PF00955.21 ETO24567.1 - 0.92 8.3 8.6 0.059 12.2 3.2 1.7 2 0 0 2 2 2 0 HCO3- transporter family Mpp10 PF04006.12 ETO24567.1 - 1.7 7.0 55.0 0.32 9.4 25.4 3.1 3 0 0 3 3 3 0 Mpp10 protein DEP PF00610.21 ETO24568.1 - 0.0046 17.0 0.1 0.041 14.0 0.2 2.4 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) NICE-3 PF07406.11 ETO24568.1 - 0.12 12.4 3.6 0.48 10.4 3.2 2.2 2 1 1 3 3 3 0 NICE-3 protein CSN5_C PF18323.1 ETO24568.1 - 0.15 13.0 6.4 0.13 13.2 2.3 2.5 2 0 0 2 2 2 0 Cop9 signalosome subunit 5 C-terminal domain RPN2_C PF18004.1 ETO24568.1 - 1.6 8.7 11.9 0.089 12.7 6.0 1.9 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF4770 PF15994.5 ETO24568.1 - 7.7 6.7 12.9 0.29 11.3 5.8 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4770) Mnd1 PF03962.15 ETO24570.1 - 0.045 14.0 0.6 2.2 8.6 0.3 2.7 2 0 0 2 2 2 0 Mnd1 HTH domain TAF6_C PF07571.13 ETO24570.1 - 0.09 13.1 0.0 0.36 11.2 0.0 2.0 2 0 0 2 2 2 0 TAF6 C-terminal HEAT repeat domain zf-ZPR1 PF03367.13 ETO24570.1 - 0.22 11.4 0.3 0.34 10.7 0.3 1.3 1 0 0 1 1 1 0 ZPR1 zinc-finger domain DUF1374 PF07118.11 ETO24571.1 - 0.13 12.8 0.0 0.25 11.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1374) UBA_4 PF14555.6 ETO24573.1 - 1.7e-08 34.1 0.0 3.2e-08 33.3 0.0 1.5 1 0 0 1 1 1 1 UBA-like domain DUF2183 PF09949.9 ETO24573.1 - 0.00064 20.0 0.2 0.0059 16.9 0.0 2.7 3 0 0 3 3 3 1 Uncharacterized conserved protein (DUF2183) Csm1_N PF18504.1 ETO24573.1 - 0.029 14.7 8.5 0.029 14.7 8.5 2.9 2 0 0 2 2 2 0 Csm1 N-terminal domain Med30 PF11315.8 ETO24573.1 - 0.042 14.1 1.8 0.042 14.1 1.8 3.1 3 0 0 3 3 3 0 Mediator complex subunit 30 PASTA PF03793.19 ETO24573.1 - 0.05 13.5 0.0 0.46 10.4 0.0 2.4 2 0 0 2 2 2 0 PASTA domain ATP19 PF11022.8 ETO24573.1 - 0.21 12.0 0.1 0.21 12.0 0.1 3.4 3 1 0 3 3 3 0 ATP synthase subunit K Fez1 PF06818.15 ETO24573.1 - 1.3 9.5 24.1 0.029 14.8 3.8 2.5 2 1 0 2 2 2 0 Fez1 LRRC37 PF15779.5 ETO24573.1 - 2 8.8 12.0 0.093 13.1 3.9 2.6 2 0 0 2 2 2 0 Leucine-rich repeat-containing protein 37 family DUF4140 PF13600.6 ETO24573.1 - 2.8 8.4 7.8 0.23 11.9 1.1 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Golgin_A5 PF09787.9 ETO24573.1 - 3.8 6.9 27.5 2.5 7.5 8.1 2.6 2 1 0 2 2 2 0 Golgin subfamily A member 5 WW PF00397.26 ETO24574.1 - 3.2e-05 23.9 0.1 3.2e-05 23.9 0.1 1.8 2 0 0 2 2 2 1 WW domain zf-RanBP PF00641.18 ETO24574.1 - 0.00083 18.6 2.9 0.0017 17.6 2.9 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO24574.1 - 0.011 15.1 0.8 0.031 13.7 0.8 1.8 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain DZR PF12773.7 ETO24574.1 - 0.035 14.1 0.8 0.071 13.1 0.8 1.5 1 0 0 1 1 1 0 Double zinc ribbon DUF150 PF02576.17 ETO24574.1 - 0.082 13.3 0.0 0.17 12.4 0.0 1.4 1 0 0 1 1 1 0 RimP N-terminal domain PPP4R2 PF09184.11 ETO24574.1 - 0.12 12.0 13.5 0.15 11.6 13.5 1.2 1 0 0 1 1 1 0 PPP4R2 Cwf_Cwc_15 PF04889.12 ETO24574.1 - 0.16 11.7 14.3 0.23 11.2 14.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DNA_pol_phi PF04931.13 ETO24574.1 - 1.5 6.8 11.0 1.7 6.7 11.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi Astro_capsid_p PF12226.8 ETO24574.1 - 1.9 7.5 11.1 3.8 6.6 10.1 1.8 2 0 0 2 2 2 0 Turkey astrovirus capsid protein Chromo PF00385.24 ETO24576.1 - 0.001 18.9 1.6 0.001 18.9 1.6 2.3 2 0 0 2 2 2 1 Chromo (CHRromatin Organisation MOdifier) domain TSC22 PF01166.18 ETO24577.1 - 0.0077 16.5 0.5 0.0077 16.5 0.5 7.8 7 2 2 9 9 9 3 TSC-22/dip/bun family TMF_DNA_bd PF12329.8 ETO24577.1 - 0.012 15.6 9.6 0.012 15.6 9.6 7.3 5 2 1 7 7 7 0 TATA element modulatory factor 1 DNA binding CALCOCO1 PF07888.11 ETO24577.1 - 0.052 12.4 68.8 2.4 7.0 22.4 3.1 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Pox_A_type_inc PF04508.12 ETO24577.1 - 0.098 12.6 0.5 0.098 12.6 0.5 5.7 7 0 0 7 7 7 0 Viral A-type inclusion protein repeat FUSC PF04632.12 ETO24577.1 - 0.23 10.0 16.2 1.3 7.5 0.7 3.4 1 1 2 3 3 3 0 Fusaric acid resistance protein family Golgin_A5 PF09787.9 ETO24577.1 - 1.3 8.4 81.3 0.049 13.1 18.4 4.4 2 2 2 4 4 4 0 Golgin subfamily A member 5 DUF4407 PF14362.6 ETO24577.1 - 1.5 8.1 48.6 0.094 12.0 21.3 3.9 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) FAM184 PF15665.5 ETO24577.1 - 10 5.9 69.8 0.2 11.4 34.8 3.5 2 1 0 3 3 3 0 Family with sequence similarity 184, A and B NARP1 PF12569.8 ETO24579.1 - 0.07 12.0 8.5 0.1 11.5 8.5 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 DDHD PF02862.17 ETO24579.1 - 0.093 12.9 3.8 0.11 12.7 3.8 1.2 1 0 0 1 1 1 0 DDHD domain CCDC71L PF15374.6 ETO24579.1 - 0.23 10.7 8.8 0.27 10.5 8.8 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L CDC45 PF02724.14 ETO24579.1 - 0.23 9.7 7.8 0.27 9.5 7.8 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO24579.1 - 0.28 11.0 10.1 0.33 10.7 10.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Eapp_C PF10238.9 ETO24579.1 - 1.1 9.3 7.3 2.3 8.3 7.3 1.6 1 0 0 1 1 1 0 E2F-associated phosphoprotein RNA_pol_Rpc4 PF05132.14 ETO24579.1 - 1.3 9.4 8.1 1.9 8.9 8.1 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 Connexin PF00029.19 ETO24579.1 - 1.5 8.5 6.3 1.9 8.2 6.3 1.2 1 0 0 1 1 1 0 Connexin RP-C_C PF11800.8 ETO24579.1 - 1.6 8.7 6.8 2.2 8.3 6.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 ETO24579.1 - 1.7 7.3 9.0 2 7.1 9.0 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO24579.1 - 5.4 6.1 7.5 6.5 5.9 7.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SNARE PF05739.19 ETO24580.1 - 2.9e-11 43.2 0.1 1.1e-10 41.3 0.1 2.1 1 0 0 1 1 1 1 SNARE domain Syntaxin PF00804.25 ETO24580.1 - 0.032 13.9 22.1 0.35 10.5 17.3 2.9 2 1 0 2 2 2 0 Syntaxin FXMR_C2 PF16098.5 ETO24580.1 - 0.11 13.0 3.4 2.2 8.8 0.2 2.8 2 0 0 2 2 2 0 Fragile X-related mental retardation protein C-terminal region 2 CorA PF01544.18 ETO24580.1 - 0.19 11.0 6.5 1.9 7.8 0.1 2.3 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein NOA36 PF06524.12 ETO24581.1 - 0.3 10.4 19.6 0.67 9.2 12.5 2.6 2 1 0 2 2 2 0 NOA36 protein Eapp_C PF10238.9 ETO24583.1 - 0.0022 18.1 1.3 0.0053 16.9 1.3 1.6 1 0 0 1 1 1 1 E2F-associated phosphoprotein DUF778 PF05608.12 ETO24583.1 - 0.32 11.3 5.3 0.77 10.1 3.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF778) ETRAMP PF09716.10 ETO24583.1 - 4.7 7.3 7.7 21 5.2 7.7 2.1 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) eIF3_subunit PF08597.10 ETO24584.1 - 0.022 14.7 16.8 0.034 14.1 16.8 1.3 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit PriC PF07445.12 ETO24584.1 - 3.7 7.4 26.9 4 7.3 11.1 2.3 2 0 0 2 2 2 0 Primosomal replication protein priC DUF948 PF06103.11 ETO24584.1 - 5.4 7.3 8.8 7.1 7.0 1.9 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.32 ETO24585.1 - 2.1e-43 145.4 27.8 2.3e-07 31.4 0.1 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24585.1 - 8.6e-11 42.0 4.0 0.13 12.6 0.0 5.5 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24585.1 - 5.7e-10 38.5 11.2 0.01 14.5 0.0 5.9 1 1 5 6 6 6 5 Nucleoporin Nup120/160 Peptidase_C9 PF01707.16 ETO24585.1 - 0.0017 18.0 0.2 0.62 9.6 0.1 3.2 3 1 0 3 3 3 1 Peptidase family C9 LydB PF16084.5 ETO24585.1 - 0.059 13.2 0.6 0.4 10.5 0.1 2.5 3 0 0 3 3 3 0 LydA-holin antagonist ER PF01133.17 ETO24587.1 - 0.043 13.8 1.2 0.1 12.6 1.2 1.7 1 0 0 1 1 1 0 Enhancer of rudimentary G-alpha PF00503.20 ETO24588.1 - 1.2e-12 47.7 1.6 1.3e-12 47.5 1.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO24588.1 - 0.0005 20.6 0.1 0.00075 20.0 0.1 1.4 1 1 0 1 1 1 1 ABC transporter RsgA_GTPase PF03193.16 ETO24588.1 - 0.025 14.5 1.4 0.51 10.2 0.1 2.4 2 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ETO24588.1 - 0.064 13.6 0.0 0.081 13.3 0.0 1.3 1 1 0 1 1 1 0 AAA ATPase domain AAA_29 PF13555.6 ETO24588.1 - 0.13 12.0 0.0 0.23 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain G-alpha PF00503.20 ETO24589.1 - 9.7e-22 77.6 3.7 1e-14 54.5 0.3 2.0 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO24589.1 - 0.013 14.9 0.1 0.087 12.3 0.0 2.0 2 0 0 2 2 2 0 ADP-ribosylation factor family DUF4752 PF15944.5 ETO24589.1 - 0.21 11.7 3.9 0.26 11.4 2.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4752) WD40 PF00400.32 ETO24590.1 - 6.9e-39 131.2 34.9 1.5e-07 32.0 1.7 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24590.1 - 2.7e-10 40.4 7.1 0.0058 16.9 0.0 5.3 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO24590.1 - 4.5e-07 29.5 4.3 9e-05 21.9 0.1 3.6 3 1 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO24590.1 - 1.9e-06 26.8 14.6 0.0089 14.7 0.8 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 WD40 PF00400.32 ETO24592.1 - 2.7e-06 28.0 3.9 5.2e-05 23.9 0.3 3.0 2 2 0 2 2 2 1 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO24592.1 - 0.04 14.0 0.0 0.097 12.7 0.0 1.7 1 1 0 1 1 1 0 Ciliary BBSome complex subunit 2, middle region CAF1 PF04857.20 ETO24593.1 - 1e-15 57.8 1.0 6e-08 32.2 0.0 2.3 2 0 0 2 2 2 2 CAF1 family ribonuclease DUF2207 PF09972.9 ETO24594.1 - 0.0019 17.0 3.4 0.032 13.0 1.0 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) Protocadherin PF08374.11 ETO24594.1 - 0.0047 16.9 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 Protocadherin LapA_dom PF06305.11 ETO24594.1 - 0.0087 15.9 0.3 3.7 7.4 0.1 2.8 2 0 0 2 2 2 2 Lipopolysaccharide assembly protein A domain DUF4834 PF16118.5 ETO24594.1 - 0.037 15.0 0.1 0.037 15.0 0.1 3.3 3 2 0 3 3 3 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 ETO24594.1 - 0.053 13.2 0.0 0.13 12.0 0.0 1.5 1 0 0 1 1 1 0 FAM176 family Neurensin PF14927.6 ETO24594.1 - 0.11 12.2 0.1 0.19 11.4 0.1 1.4 1 0 0 1 1 1 0 Neurensin DUF2976 PF11190.8 ETO24594.1 - 0.37 10.6 4.1 1.9 8.3 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2976) EphA2_TM PF14575.6 ETO24594.1 - 0.48 11.3 2.0 3.4 8.6 0.0 3.3 3 1 1 4 4 4 0 Ephrin type-A receptor 2 transmembrane domain RP-C PF03428.13 ETO24596.1 - 0.086 12.5 0.4 0.086 12.5 0.4 3.4 4 0 0 4 4 4 0 Replication protein C N-terminal domain Styelin PF17562.2 ETO24596.1 - 0.19 12.1 4.6 5 7.6 0.6 3.2 2 0 0 2 2 2 0 Styelin BRE1 PF08647.11 ETO24596.1 - 0.2 11.7 0.0 0.2 11.7 0.0 5.0 2 1 2 4 4 4 0 BRE1 E3 ubiquitin ligase Csm1_N PF18504.1 ETO24596.1 - 9.9 6.6 46.6 1.6 9.1 2.6 5.4 4 1 0 5 5 5 0 Csm1 N-terminal domain PX PF00787.24 ETO24597.1 - 2.3e-06 27.6 0.2 6.7e-06 26.1 0.2 1.8 1 0 0 1 1 1 1 PX domain DUF5366 PF17328.2 ETO24597.1 - 0.016 15.3 3.3 0.028 14.5 3.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5366) LAP1C PF05609.12 ETO24597.1 - 0.055 12.6 6.7 0.074 12.1 6.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Herpes_LAMP2 PF06126.11 ETO24597.1 - 0.075 11.7 2.1 0.11 11.1 2.1 1.2 1 0 0 1 1 1 0 Herpesvirus Latent membrane protein 2 Hid1 PF12722.7 ETO24597.1 - 1.8 6.6 9.2 2.5 6.1 9.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macoilin PF09726.9 ETO24597.1 - 3.1 6.3 12.4 4.1 5.8 12.4 1.1 1 0 0 1 1 1 0 Macoilin family Peptidase_C14 PF00656.22 ETO24598.1 - 8.8e-08 32.4 0.3 1.3e-07 31.8 0.3 1.3 1 1 0 1 1 1 1 Caspase domain DUF4325 PF14213.6 ETO24598.1 - 0.036 13.8 1.0 14 5.5 0.0 3.2 3 0 0 3 3 3 0 STAS-like domain of unknown function (DUF4325) Ferritin PF00210.24 ETO24599.1 - 0.0068 16.3 0.6 0.66 9.9 0.2 2.1 2 0 0 2 2 2 2 Ferritin-like domain Anti-adapt_IraP PF10796.9 ETO24599.1 - 0.056 14.0 0.5 0.22 12.1 0.0 2.1 1 1 1 2 2 2 0 Sigma-S stabilisation anti-adaptor protein RRM_1 PF00076.22 ETO24600.1 - 9.7e-21 73.4 0.0 1.7e-13 50.2 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCCH_4 PF18044.1 ETO24600.1 - 0.00019 21.1 8.2 0.00036 20.2 8.2 1.5 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETO24600.1 - 0.00024 21.1 10.1 0.00055 19.9 10.1 1.7 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 ETO24600.1 - 0.007 17.1 2.7 0.007 17.1 2.7 2.3 2 1 0 2 2 2 1 Torus domain zf-CCCH PF00642.24 ETO24600.1 - 0.088 12.7 5.6 0.21 11.5 5.6 1.6 1 0 0 1 1 1 0 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ETO24600.1 - 2.7 8.3 7.1 0.61 10.3 2.7 2.1 2 0 0 2 2 2 0 Zinc-finger containing family FSA_C PF10479.9 ETO24601.1 - 0.51 8.4 11.5 0.64 8.1 11.5 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 ETO24601.1 - 7.5 6.5 23.6 12 5.9 23.6 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein MAP65_ASE1 PF03999.12 ETO24602.1 - 0.15 10.7 4.7 0.16 10.7 4.7 1.0 1 0 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) SOG2 PF10428.9 ETO24602.1 - 9.2 5.3 9.9 10 5.2 9.9 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein WD40 PF00400.32 ETO24603.1 - 0.0018 19.1 0.1 0.0018 19.1 0.1 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF3446 PF11928.8 ETO24603.1 - 0.0046 17.2 6.2 0.0096 16.2 6.2 1.5 1 0 0 1 1 1 1 Early growth response N-terminal domain SR-25 PF10500.9 ETO24603.1 - 0.24 11.0 20.7 0.065 12.8 17.2 1.7 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Raftlin PF15250.6 ETO24603.1 - 4.5 5.9 11.5 6.1 5.5 11.5 1.2 1 0 0 1 1 1 0 Raftlin WD40 PF00400.32 ETO24604.1 - 3.7e-37 125.7 26.6 1.8e-06 28.6 0.5 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24604.1 - 1.6e-09 37.9 0.4 0.33 11.3 0.0 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24604.1 - 2.6e-09 36.3 5.9 0.46 9.1 0.4 5.5 3 1 1 5 5 5 5 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO24604.1 - 0.015 15.1 0.4 0.3 10.9 0.0 3.0 4 0 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain Rieske_2 PF13806.6 ETO24604.1 - 0.049 13.6 0.0 0.49 10.4 0.0 2.6 3 0 0 3 3 3 0 Rieske-like [2Fe-2S] domain DUF3637 PF12337.8 ETO24604.1 - 0.11 12.8 0.1 0.22 11.9 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3637) WD40 PF00400.32 ETO24605.1 - 4.8e-37 125.3 21.6 1.8e-05 25.4 0.1 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24605.1 - 3.1e-12 46.6 5.6 0.085 13.2 0.1 6.1 6 2 0 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24605.1 - 7.9e-11 41.3 9.4 0.041 12.5 0.2 5.8 3 3 2 5 5 5 5 Nucleoporin Nup120/160 Pkinase PF00069.25 ETO24606.1 - 1.1e-55 188.8 0.1 1.3e-55 188.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24606.1 - 2.7e-37 128.4 0.0 3.6e-37 128.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO24606.1 - 1.1e-06 28.1 0.0 1.4e-06 27.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like RIO1 PF01163.22 ETO24606.1 - 0.00011 21.9 0.0 0.00016 21.3 0.0 1.3 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ETO24606.1 - 0.00042 20.3 0.0 0.00059 19.8 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO24606.1 - 0.00057 19.3 0.2 0.00089 18.7 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO24606.1 - 0.0026 16.8 0.1 0.0035 16.4 0.1 1.2 1 0 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO24606.1 - 0.0083 14.9 0.0 0.014 14.2 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase SmpB PF01668.18 ETO24606.1 - 0.062 13.2 0.2 0.062 13.2 0.2 1.8 3 0 0 3 3 3 0 SmpB protein DUF1345 PF07077.11 ETO24606.1 - 0.063 13.0 0.0 0.093 12.4 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1345) YukC PF10140.9 ETO24606.1 - 0.066 12.0 0.1 0.066 12.0 0.1 1.5 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein YukC DUF3169 PF11368.8 ETO24608.1 - 0.0019 17.8 0.1 0.0027 17.3 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) Orf78 PF06024.12 ETO24608.1 - 0.095 13.0 0.8 0.14 12.5 0.1 1.7 2 0 0 2 2 2 0 Orf78 (ac78) Ureide_permease PF07168.11 ETO24608.1 - 0.11 11.2 0.3 0.16 10.7 0.3 1.1 1 0 0 1 1 1 0 Ureide permease Afi1 PF07792.12 ETO24608.1 - 6.3 7.3 11.1 0.4 11.1 5.4 1.9 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking PcrB PF01884.17 ETO24610.1 - 0.018 14.5 0.0 0.029 13.8 0.0 1.2 1 0 0 1 1 1 0 PcrB family ECSCR PF15820.5 ETO24610.1 - 3.4 7.6 0.0 3.4 7.6 0.0 3.0 2 1 1 3 3 3 0 Endothelial cell-specific chemotaxis regulator SOG2 PF10428.9 ETO24612.1 - 9.3 5.3 23.1 11 5.1 23.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Pkinase PF00069.25 ETO24613.1 - 1.4e-73 247.6 0.2 3.7e-63 213.4 0.0 2.5 2 1 1 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24613.1 - 3.7e-35 121.5 0.0 1.2e-32 113.2 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO24613.1 - 2.8e-05 24.2 0.0 0.0009 19.2 0.0 2.7 2 1 0 3 3 3 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO24613.1 - 3.4e-05 22.8 1.7 8.7e-05 21.5 1.7 1.9 1 1 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO24613.1 - 0.001 18.5 0.6 0.0045 16.4 0.0 2.2 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO24613.1 - 0.0046 16.3 0.3 0.03 13.7 0.0 2.3 2 1 0 2 2 2 1 Kinase-like DUF4407 PF14362.6 ETO24614.1 - 7.9 5.7 5.8 8.7 5.6 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 ETO24615.1 - 7.8e-74 241.8 24.9 2.2e-11 44.1 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24615.1 - 1.1e-24 86.5 4.4 0.00096 19.4 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24615.1 - 4.6e-17 62.0 0.0 0.01 14.8 0.0 6.7 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO24615.1 - 1e-14 54.9 2.0 3.7e-05 23.7 0.0 3.7 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO24615.1 - 4.7e-09 35.9 0.9 5.9 7.0 0.0 6.5 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO24615.1 - 7.5e-08 32.0 0.0 0.13 11.6 0.0 3.6 1 1 5 6 6 6 5 WD40-like domain Cytochrom_D1 PF02239.16 ETO24615.1 - 8.6e-06 24.5 0.1 0.074 11.6 0.0 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO24615.1 - 0.0076 15.0 4.2 0.18 10.5 0.1 3.6 1 1 1 3 3 3 1 Nup133 N terminal like Str_synth PF03088.16 ETO24615.1 - 0.01 15.9 0.0 14 5.9 0.0 3.8 3 1 2 5 5 5 0 Strictosidine synthase DUF4279 PF14106.6 ETO24615.1 - 0.067 13.4 0.1 8.7 6.6 0.0 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4279) PDDEXK_1 PF12705.7 ETO24615.1 - 0.15 11.9 0.1 2.5 7.9 0.0 2.8 4 0 0 4 4 4 0 PD-(D/E)XK nuclease superfamily DnaJ PF00226.31 ETO24618.1 - 1.4e-13 50.8 0.3 3.1e-13 49.6 0.3 1.6 1 0 0 1 1 1 1 DnaJ domain DUF3395 PF11875.8 ETO24618.1 - 0.0011 18.9 1.3 0.0011 18.9 1.3 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF3395) CDC37_N PF03234.14 ETO24618.1 - 0.07 14.1 3.9 0.11 13.5 3.9 1.2 1 0 0 1 1 1 0 Cdc37 N terminal kinase binding AAA_11 PF13086.6 ETO24618.1 - 0.14 11.9 1.4 0.16 11.7 1.4 1.1 1 0 0 1 1 1 0 AAA domain C9orf72-like PF15019.6 ETO24621.1 - 1.2e-23 83.9 3.4 5.5e-23 81.8 0.1 2.5 3 0 0 3 3 3 2 C9orf72-like protein family DUF3395 PF11875.8 ETO24622.1 - 6.3e-10 39.2 1.7 9.4e-10 38.6 1.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3395) DUF4667 PF15700.5 ETO24622.1 - 0.04 14.0 0.3 0.061 13.4 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4667) Apis_Csd PF11671.8 ETO24622.1 - 3.8 7.5 10.7 0.2 11.6 3.9 2.0 2 0 0 2 2 2 0 Complementary sex determiner protein Methyltransf_11 PF08241.12 ETO24623.1 - 1.2e-05 25.9 0.1 2.4e-05 24.9 0.1 1.6 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO24623.1 - 0.00038 21.1 0.1 0.002 18.8 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain FGF PF00167.18 ETO24623.1 - 0.019 15.1 0.2 0.03 14.4 0.2 1.3 1 0 0 1 1 1 0 Fibroblast growth factor YIF1 PF03878.15 ETO24624.1 - 4.7 6.6 12.5 0.18 11.3 3.2 2.1 2 0 0 2 2 2 0 YIF1 CPBP PF02517.16 ETO24624.1 - 5.3 7.5 8.1 3.6 8.0 4.9 2.1 2 1 0 2 2 2 0 CPBP intramembrane metalloprotease Kinocilin PF15033.6 ETO24625.1 - 0.22 11.2 0.2 0.35 10.5 0.2 1.3 1 0 0 1 1 1 0 Kinocilin protein MAP65_ASE1 PF03999.12 ETO24626.1 - 0.0024 16.6 0.3 0.0024 16.6 0.3 1.8 2 0 0 2 2 2 1 Microtubule associated protein (MAP65/ASE1 family) Mei5 PF10376.9 ETO24626.1 - 0.025 14.4 2.1 0.036 13.9 2.1 1.3 1 0 0 1 1 1 0 Double-strand recombination repair protein SCF PF02404.15 ETO24627.1 - 0.94 8.8 4.3 1.8 7.8 1.0 2.3 1 1 1 2 2 2 0 Stem cell factor Tim54 PF11711.8 ETO24628.1 - 0.071 11.9 10.5 0.078 11.7 10.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF2151 PF10221.9 ETO24628.1 - 0.12 10.9 10.5 0.12 11.0 10.5 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator TP53IP5 PF15331.6 ETO24628.1 - 0.18 12.0 9.1 0.25 11.5 9.1 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Trypan_PARP PF05887.11 ETO24628.1 - 0.2 11.6 8.5 0.29 11.1 8.5 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) NPR3 PF03666.13 ETO24628.1 - 0.38 9.5 11.2 0.38 9.5 11.2 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO24628.1 - 0.39 9.4 9.5 0.37 9.5 9.5 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO24628.1 - 0.42 8.8 14.7 0.47 8.7 14.7 1.0 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO24628.1 - 1.1 7.7 9.0 1.2 7.6 9.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Zip PF02535.22 ETO24628.1 - 1.6 7.8 6.9 1.5 7.9 6.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.8 ETO24628.1 - 1.9 8.5 8.1 3.4 7.7 8.1 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region CobT PF06213.12 ETO24628.1 - 2.1 7.7 14.8 3.1 7.1 14.8 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Hid1 PF12722.7 ETO24628.1 - 2.1 6.4 10.7 2.4 6.2 10.7 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein MDM10 PF12519.8 ETO24628.1 - 2.1 7.1 8.8 2.2 7.0 8.8 1.2 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 Vfa1 PF08432.10 ETO24628.1 - 2.1 8.6 26.8 0.25 11.6 22.9 1.4 2 0 0 2 2 1 0 AAA-ATPase Vps4-associated protein 1 DUF1003 PF06210.11 ETO24628.1 - 2.3 8.4 3.4 6.2 7.0 3.4 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) CPSF100_C PF13299.6 ETO24628.1 - 3 8.0 12.4 5.2 7.2 12.4 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF913 PF06025.12 ETO24628.1 - 3.2 6.6 10.7 4.2 6.3 10.7 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4637 PF15470.6 ETO24628.1 - 3.3 7.4 14.0 6.3 6.5 14.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3464 PF11947.8 ETO24628.1 - 4 7.2 14.6 7.2 6.4 14.6 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DNA_pol_phi PF04931.13 ETO24628.1 - 4.9 5.1 16.0 6.5 4.7 16.0 1.1 1 0 0 1 1 1 0 DNA polymerase phi SOBP PF15279.6 ETO24628.1 - 6.1 7.4 10.0 5.3 7.6 8.9 1.3 1 1 0 1 1 1 0 Sine oculis-binding protein Sec62 PF03839.16 ETO24628.1 - 8.5 5.8 17.2 13 5.3 17.2 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 GNAT_acetyltr_2 PF13718.6 ETO24628.1 - 9.9 5.5 8.6 16 4.8 8.6 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase 2 CDC45 PF02724.14 ETO24629.1 - 6.1 5.0 20.4 0.31 9.3 12.7 2.2 2 0 0 2 2 2 0 CDC45-like protein CUE PF02845.16 ETO24631.1 - 0.0019 17.9 0.1 0.0019 17.9 0.1 2.2 2 0 0 2 2 2 1 CUE domain PUB PF09409.10 ETO24631.1 - 0.0084 16.0 2.6 0.025 14.5 0.7 2.7 2 1 0 2 2 2 1 PUB domain PCI PF01399.27 ETO24631.1 - 0.012 16.1 3.6 0.013 16.0 1.0 2.1 1 1 1 2 2 2 0 PCI domain Phosphoesterase PF04185.14 ETO24632.1 - 4.5e-28 98.5 0.1 6e-28 98.0 0.1 1.1 1 0 0 1 1 1 1 Phosphoesterase family LRR_2 PF07723.13 ETO24633.1 - 0.0027 18.3 0.2 0.0096 16.6 0.2 2.0 1 0 0 1 1 1 1 Leucine Rich Repeat LRR_4 PF12799.7 ETO24633.1 - 0.006 17.0 2.2 0.13 12.7 0.2 3.1 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) adh_short PF00106.25 ETO24635.1 - 8.9e-35 119.9 0.0 1.2e-34 119.5 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO24635.1 - 1.2e-18 67.6 0.0 1.5e-18 67.3 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO24635.1 - 3.7e-07 30.2 0.0 5.9e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO24635.1 - 0.0008 18.6 0.0 0.0012 18.0 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF1776 PF08643.10 ETO24635.1 - 0.07 12.5 0.0 0.1 11.9 0.0 1.2 1 0 0 1 1 1 0 Fungal family of unknown function (DUF1776) WD40 PF00400.32 ETO24636.1 - 4.8e-126 407.0 45.7 7.1e-10 39.3 0.1 14.6 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24636.1 - 5.3e-30 103.6 9.4 0.065 13.5 0.0 12.7 1 1 10 12 12 12 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24636.1 - 2.6e-19 69.4 18.2 0.076 12.0 0.1 12.2 3 2 9 13 13 13 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO24636.1 - 1.5e-14 54.1 0.1 0.11 11.8 0.0 6.7 2 2 3 6 6 6 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO24636.1 - 3.1e-09 35.9 5.2 0.062 11.8 0.1 5.8 3 2 2 6 6 6 4 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO24636.1 - 1.4e-07 31.0 1.7 3.1e-07 29.9 1.7 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) NACHT PF05729.12 ETO24636.1 - 1.9e-07 31.2 0.0 4.2e-07 30.0 0.0 1.6 1 0 0 1 1 1 1 NACHT domain PD40 PF07676.12 ETO24636.1 - 5e-06 26.3 8.7 11 6.1 0.1 7.6 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO24636.1 - 9.1e-05 22.5 18.8 1.7 8.7 0.0 8.7 4 3 5 9 9 9 2 Family of unknown function (DUF5570) Pentapeptide_4 PF13599.6 ETO24636.1 - 0.00061 19.9 0.3 0.0023 18.1 0.3 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Me-amine-dh_H PF06433.11 ETO24636.1 - 0.00074 18.5 0.1 5.5 5.8 0.0 5.1 6 0 0 6 6 6 1 Methylamine dehydrogenase heavy chain (MADH) DUF4999 PF16390.5 ETO24636.1 - 0.0013 19.0 0.8 14 6.0 0.0 5.7 6 0 0 6 6 6 0 Domain of unknown function SAND PF01342.21 ETO24636.1 - 0.0017 18.0 1.9 3.7 7.3 0.1 4.0 4 0 0 4 4 4 2 SAND domain AcetylCoA_hyd_C PF13336.6 ETO24636.1 - 0.0055 16.7 2.8 51 3.8 0.0 5.8 7 0 0 7 7 7 0 Acetyl-CoA hydrolase/transferase C-terminal domain PQQ PF01011.21 ETO24636.1 - 0.0059 16.5 0.0 8 6.6 0.0 5.0 5 0 0 5 5 5 1 PQQ enzyme repeat Str_synth PF03088.16 ETO24636.1 - 0.013 15.6 3.0 18 5.6 0.0 5.4 6 1 1 7 7 4 0 Strictosidine synthase AAA_22 PF13401.6 ETO24636.1 - 0.017 15.4 0.0 0.058 13.7 0.0 1.9 1 0 0 1 1 1 0 AAA domain Pentapeptide_3 PF13576.6 ETO24636.1 - 0.028 14.6 2.9 0.033 14.3 0.3 2.5 2 1 0 2 2 2 0 Pentapeptide repeats (9 copies) Mid2 PF04478.12 ETO24636.1 - 0.029 14.2 0.1 0.96 9.3 0.0 3.4 3 1 1 4 4 4 0 Mid2 like cell wall stress sensor Proteasome_A_N PF10584.9 ETO24636.1 - 0.067 12.9 11.6 7.9 6.3 0.0 5.9 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature MFS_1 PF07690.16 ETO24638.1 - 0.0059 15.6 0.6 0.053 12.4 0.1 2.0 2 0 0 2 2 2 2 Major Facilitator Superfamily MatE PF01554.18 ETO24639.1 - 1.6e-25 89.6 27.0 4.7e-17 62.1 3.8 3.9 3 1 2 5 5 5 2 MatE Menin PF05053.13 ETO24640.1 - 0.26 9.6 8.6 0.3 9.4 8.6 1.1 1 0 0 1 1 1 0 Menin SOG2 PF10428.9 ETO24640.1 - 0.78 8.9 7.6 0.88 8.7 7.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Tmemb_cc2 PF10267.9 ETO24640.1 - 0.88 8.6 6.5 1.2 8.2 6.5 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Presenilin PF01080.17 ETO24640.1 - 1.9 7.2 5.7 2.2 7.0 5.7 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO24640.1 - 1.9 7.6 4.1 2.2 7.4 4.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SAC3_GANP PF03399.16 ETO24642.1 - 2.8e-19 69.6 14.6 2.9e-17 63.0 14.6 2.4 1 1 0 1 1 1 1 SAC3/GANP family CSN8_PSD8_EIF3K PF10075.9 ETO24642.1 - 8.3e-06 25.8 0.4 2.1e-05 24.5 0.4 1.6 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Mad3_BUB1_I PF08311.12 ETO24644.1 - 8.8e-12 45.1 0.5 8.8e-12 45.1 0.5 2.1 2 0 0 2 2 2 1 Mad3/BUB1 homology region 1 BCIP PF13862.6 ETO24644.1 - 3.3 7.4 9.6 6.8 6.4 7.8 2.4 1 1 0 1 1 1 0 p21-C-terminal region-binding protein Abhydrolase_6 PF12697.7 ETO24645.1 - 1.9e-05 25.4 0.0 2.7e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETO24645.1 - 0.0018 17.6 0.0 0.0034 16.7 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ETO24645.1 - 0.12 12.2 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold NicO PF03824.16 ETO24645.1 - 0.31 10.4 1.3 0.58 9.5 1.3 1.5 1 0 0 1 1 1 0 High-affinity nickel-transport protein SelP_N PF04592.14 ETO24645.1 - 2.1 7.7 24.0 0.15 11.5 18.6 1.7 2 0 0 2 2 2 0 Selenoprotein P, N terminal region DDHD PF02862.17 ETO24648.1 - 0.12 12.6 5.1 0.15 12.2 5.1 1.2 1 0 0 1 1 1 0 DDHD domain Sporozoite_P67 PF05642.11 ETO24648.1 - 0.21 9.7 15.5 0.3 9.1 15.5 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Macoilin PF09726.9 ETO24648.1 - 1.6 7.2 14.6 1.8 7.0 14.6 1.0 1 0 0 1 1 1 0 Macoilin family TFB6 PF17110.5 ETO24648.1 - 2.5 7.8 6.3 4.4 7.0 6.3 1.5 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NOA36 PF06524.12 ETO24648.1 - 2.5 7.3 10.7 3.9 6.7 10.7 1.3 1 0 0 1 1 1 0 NOA36 protein FSA_C PF10479.9 ETO24648.1 - 3.1 5.8 10.6 3.5 5.6 10.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PPP4R2 PF09184.11 ETO24648.1 - 3.3 7.2 21.6 4.3 6.9 21.6 1.1 1 0 0 1 1 1 0 PPP4R2 DAAD PF18752.1 ETO24648.1 - 4.5 7.0 13.3 10 5.9 13.4 1.4 1 1 0 1 1 1 0 Dictyosteliid AID/APOBEC-like Deaminase DUF4484 PF14831.6 ETO24648.1 - 5.1 7.1 11.6 7.8 6.5 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4484) DUF4637 PF15470.6 ETO24648.1 - 6.1 6.5 12.4 11 5.7 12.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF966 PF06136.13 ETO24648.1 - 6.6 6.3 12.8 7.9 6.1 12.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF966) ALMT PF11744.8 ETO24648.1 - 6.6 5.4 9.1 7.5 5.3 9.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Dicty_REP PF05086.12 ETO24648.1 - 7.9 4.3 20.4 9.7 4.0 20.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SprA-related PF12118.8 ETO24649.1 - 0.00012 21.3 23.8 0.00012 21.3 23.8 3.7 4 0 0 4 4 4 1 SprA-related family TFIIA PF03153.13 ETO24649.1 - 0.094 12.7 55.5 0.27 11.2 23.1 3.3 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit CENP-B_dimeris PF09026.10 ETO24649.1 - 4.5 7.7 13.0 8.4 6.9 1.5 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain DnaJ PF00226.31 ETO24650.1 - 2e-12 47.1 4.9 1.7e-11 44.0 4.9 2.3 1 1 0 1 1 1 1 DnaJ domain TOPRIM_C PF16898.5 ETO24650.1 - 0.13 12.6 8.5 0.21 11.9 8.3 1.4 1 1 0 1 1 1 0 C-terminal associated domain of TOPRIM ComGG PF14173.6 ETO24651.1 - 0.022 15.2 0.0 0.022 15.2 0.0 2.3 3 0 0 3 3 3 0 ComG operon protein 7 Pfk_N PF18468.1 ETO24651.1 - 0.05 14.0 0.8 0.5 10.8 0.1 2.7 2 0 0 2 2 2 0 Phosphofructokinase N-terminal domain yeast Phage_holin_3_6 PF07332.11 ETO24651.1 - 0.09 12.8 0.2 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III TctB PF07331.11 ETO24651.1 - 0.18 12.1 2.1 1.6 9.0 0.8 2.3 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family Oxidored_q3 PF00499.20 ETO24651.1 - 0.44 10.3 3.5 1.8 8.3 2.9 2.5 1 1 1 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF4834 PF16118.5 ETO24651.1 - 1.3 10.1 0.0 1.3 10.1 0.0 5.9 6 1 0 6 6 6 0 Domain of unknown function (DUF4834) Complex1_30kDa PF00329.19 ETO24652.1 - 2.1e-31 109.1 0.1 6.1e-31 107.6 0.0 1.7 2 0 0 2 2 2 1 Respiratory-chain NADH dehydrogenase, 30 Kd subunit Vps39_1 PF10366.9 ETO24654.1 - 0.0082 16.4 6.2 0.22 11.8 0.1 4.2 3 1 0 4 4 4 1 Vacuolar sorting protein 39 domain 1 TPR_4 PF07721.14 ETO24654.1 - 0.016 15.8 0.1 0.1 13.2 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Clathrin PF00637.20 ETO24654.1 - 0.058 13.3 0.2 0.058 13.3 0.2 2.8 3 1 0 3 3 3 0 Region in Clathrin and VPS TPR_7 PF13176.6 ETO24654.1 - 0.11 12.6 2.7 23 5.3 0.1 4.1 3 1 0 3 3 3 0 Tetratricopeptide repeat BofC_C PF08955.10 ETO24654.1 - 0.13 12.3 0.0 0.42 10.7 0.0 1.9 1 0 0 1 1 1 0 BofC C-terminal domain TPR_12 PF13424.6 ETO24654.1 - 2 8.8 4.9 40 4.6 0.2 4.3 3 2 0 3 3 3 0 Tetratricopeptide repeat CPSase_L_D2 PF02786.17 ETO24655.1 - 1.4e-85 286.1 0.1 1.2e-55 188.4 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain CPSase_L_D3 PF02787.19 ETO24655.1 - 5.2e-41 139.8 1.0 1.2e-40 138.7 0.1 2.1 2 0 0 2 2 2 1 Carbamoyl-phosphate synthetase large chain, oligomerisation domain MGS PF02142.22 ETO24655.1 - 8.9e-18 64.3 0.0 3.2e-17 62.5 0.0 2.0 1 0 0 1 1 1 1 MGS-like domain ATPgrasp_Ter PF15632.6 ETO24655.1 - 1.1e-11 44.6 0.3 2.2e-05 24.2 0.1 2.5 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp PF02222.22 ETO24655.1 - 1.4e-10 41.0 0.0 3e-10 39.9 0.0 1.5 1 0 0 1 1 1 1 ATP-grasp domain Dala_Dala_lig_C PF07478.13 ETO24655.1 - 6.4e-08 32.4 0.4 5.4e-07 29.4 0.1 2.4 2 0 0 2 2 2 1 D-ala D-ala ligase C-terminus RimK PF08443.11 ETO24655.1 - 0.00023 20.8 0.1 0.001 18.7 0.0 2.0 2 0 0 2 2 2 1 RimK-like ATP-grasp domain ATP-grasp_3 PF02655.14 ETO24655.1 - 0.0032 17.5 0.1 0.18 11.9 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain CdiA_C_tRNase PF18664.1 ETO24655.1 - 0.045 13.9 0.5 0.13 12.5 0.0 2.0 2 0 0 2 2 2 0 CdiA C-terminal tRNase domain FAM209 PF15206.6 ETO24656.1 - 0.0023 17.7 6.4 0.076 12.8 4.1 2.2 2 0 0 2 2 2 1 FAM209 family Connexin PF00029.19 ETO24656.1 - 0.0057 16.4 6.2 0.0057 16.4 6.2 1.8 1 1 0 2 2 2 1 Connexin Tim54 PF11711.8 ETO24656.1 - 0.006 15.4 3.3 0.0067 15.3 3.3 1.2 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF2500 PF10694.9 ETO24656.1 - 0.0072 16.8 1.4 0.028 14.9 1.4 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2500) SID-1_RNA_chan PF13965.6 ETO24656.1 - 0.013 13.9 6.1 0.025 13.0 2.1 2.0 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 RPA43_OB PF17875.1 ETO24656.1 - 0.022 15.4 0.3 0.14 12.7 0.1 2.1 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Afi1 PF07792.12 ETO24656.1 - 0.054 14.0 0.9 0.054 14.0 0.9 1.8 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF1003 PF06210.11 ETO24656.1 - 0.056 13.6 0.0 0.098 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1003) Ureide_permease PF07168.11 ETO24656.1 - 0.079 11.7 1.0 0.14 10.9 1.0 1.3 1 0 0 1 1 1 0 Ureide permease Presenilin PF01080.17 ETO24656.1 - 0.094 11.5 1.7 0.12 11.1 1.7 1.1 1 0 0 1 1 1 0 Presenilin EphA2_TM PF14575.6 ETO24656.1 - 0.12 13.3 2.5 0.17 12.8 1.3 1.9 2 0 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain OSTbeta PF15048.6 ETO24656.1 - 0.12 12.5 2.9 0.22 11.7 2.9 1.3 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein EOS1 PF12326.8 ETO24656.1 - 0.14 12.1 3.5 0.46 10.4 1.8 2.1 2 0 0 2 2 2 0 N-glycosylation protein Protocadherin PF08374.11 ETO24656.1 - 0.2 11.6 7.7 0.41 10.6 7.7 1.5 1 0 0 1 1 1 0 Protocadherin SHR3_chaperone PF08229.11 ETO24656.1 - 0.21 10.5 1.2 0.4 9.6 1.2 1.4 1 0 0 1 1 1 0 ER membrane protein SH3 FHIPEP PF00771.20 ETO24656.1 - 0.3 9.5 0.3 0.4 9.1 0.3 1.1 1 0 0 1 1 1 0 FHIPEP family EIIBC-GUT_N PF03612.14 ETO24656.1 - 0.79 9.4 6.2 1.3 8.7 6.2 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus MAP17 PF15807.5 ETO24656.1 - 0.86 9.8 8.7 0.17 12.1 5.2 1.6 2 0 0 2 2 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 FAM176 PF14851.6 ETO24656.1 - 1.2 8.8 3.2 0.42 10.3 0.6 1.6 2 0 0 2 2 2 0 FAM176 family Folate_carrier PF01770.18 ETO24656.1 - 1.3 7.6 4.2 0.49 9.1 0.9 1.7 2 0 0 2 2 2 0 Reduced folate carrier O-antigen_lig PF13425.6 ETO24656.1 - 1.5 7.6 4.3 0.55 9.0 2.0 1.4 2 0 0 2 2 2 0 O-antigen ligase like membrane protein Cnd1_N PF12922.7 ETO24656.1 - 1.8 8.4 10.9 2 8.2 7.7 2.0 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term HA2 PF04408.23 ETO24656.1 - 2 8.8 4.8 4.5 7.6 4.8 1.6 1 0 0 1 1 1 0 Helicase associated domain (HA2) DUF3438 PF11920.8 ETO24656.1 - 2.6 7.2 4.0 4 6.6 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) YMF19 PF02326.15 ETO24656.1 - 2.7 8.8 9.2 12 6.8 5.0 2.5 2 0 0 2 2 2 0 Plant ATP synthase F0 NARP1 PF12569.8 ETO24656.1 - 2.8 6.7 15.5 4 6.2 15.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Conotoxin PF02950.17 ETO24656.1 - 3.4 8.7 10.5 17 6.5 9.3 2.7 2 1 0 2 2 2 0 Conotoxin Miff PF05644.11 ETO24656.1 - 3.8 7.1 8.0 7.5 6.1 8.1 1.6 1 1 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff DUF3464 PF11947.8 ETO24656.1 - 6.4 6.5 15.4 13 5.5 15.4 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Peroxin-13_N PF04088.13 ETO24656.1 - 6.8 7.0 8.3 4.4 7.6 6.4 1.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region CLN3 PF02487.17 ETO24656.1 - 8 5.4 6.2 3.1 6.7 4.0 1.5 1 1 1 2 2 2 0 CLN3 protein Beta-lactamase PF00144.24 ETO24657.1 - 2e-43 148.9 0.0 2.4e-43 148.6 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Beta-lactamase2 PF13354.6 ETO24657.1 - 0.027 14.1 0.0 0.043 13.4 0.0 1.5 1 1 0 1 1 1 0 Beta-lactamase enzyme family Presenilin PF01080.17 ETO24658.1 - 0.011 14.5 22.0 0.013 14.2 22.0 1.1 1 0 0 1 1 1 0 Presenilin ORC6 PF05460.13 ETO24658.1 - 0.13 11.5 17.3 0.16 11.2 17.3 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Dapper PF15268.6 ETO24658.1 - 0.14 11.0 18.0 0.14 11.0 18.0 1.1 1 0 0 1 1 1 0 Dapper AF-4 PF05110.13 ETO24658.1 - 0.16 10.1 23.1 0.15 10.1 23.1 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Nop14 PF04147.12 ETO24658.1 - 0.32 9.2 30.4 0.34 9.1 30.4 1.1 1 0 0 1 1 1 0 Nop14-like family DUF966 PF06136.13 ETO24658.1 - 0.34 10.6 16.9 0.36 10.5 16.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Hamartin PF04388.12 ETO24658.1 - 1 7.9 14.6 1 7.9 14.6 1.1 1 0 0 1 1 1 0 Hamartin protein GREB1 PF15782.5 ETO24658.1 - 2 5.4 17.1 2.1 5.3 17.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Membralin PF09746.9 ETO24658.1 - 3 6.8 11.6 3.4 6.6 11.6 1.1 1 0 0 1 1 1 0 Tumour-associated protein Spt20 PF12090.8 ETO24658.1 - 3.6 7.2 28.7 6.4 6.3 28.7 1.5 1 0 0 1 1 1 0 Spt20 family DUF4551 PF15087.6 ETO24658.1 - 4.4 6.0 14.4 4.4 6.0 14.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Borrelia_P83 PF05262.11 ETO24658.1 - 5.7 5.3 27.0 5.7 5.3 27.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein Spt20 PF12090.8 ETO24659.1 - 2.3 7.8 10.0 5 6.7 10.0 1.5 1 0 0 1 1 1 0 Spt20 family RRM_1 PF00076.22 ETO24661.1 - 5.1e-05 23.0 0.0 0.00013 21.7 0.0 1.7 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SDF PF00375.18 ETO24661.1 - 0.045 12.8 0.0 0.055 12.5 0.0 1.1 1 0 0 1 1 1 0 Sodium:dicarboxylate symporter family ubiquitin PF00240.23 ETO24662.1 - 1.2e-27 95.4 0.1 3.3e-27 94.0 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO24662.1 - 4e-15 55.4 0.1 1.2e-14 53.8 0.1 1.9 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO24662.1 - 1e-05 25.9 0.1 6e-05 23.4 0.1 2.3 2 0 0 2 2 2 1 Ubiquitin-like domain Hint PF01079.20 ETO24662.1 - 0.00096 18.7 0.0 0.0019 17.8 0.0 1.4 1 0 0 1 1 1 1 Hint module TBK1_ULD PF18396.1 ETO24662.1 - 0.0026 17.6 0.1 0.014 15.3 0.0 2.1 2 0 0 2 2 2 1 TANK binding kinase 1 ubiquitin-like domain Hom_end_hint PF05203.16 ETO24662.1 - 0.0085 16.1 0.5 0.024 14.6 0.1 2.0 2 0 0 2 2 2 1 Hom_end-associated Hint AXH PF08517.12 ETO24662.1 - 0.017 15.6 1.1 0.052 14.1 0.0 2.4 3 0 0 3 3 2 0 Ataxin-1 and HBP1 module (AXH) FAM176 PF14851.6 ETO24662.1 - 0.028 14.1 4.0 0.057 13.1 1.3 2.3 2 0 0 2 2 2 0 FAM176 family Hint_2 PF13403.6 ETO24662.1 - 0.062 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Hint domain DUF719 PF05334.13 ETO24662.1 - 0.066 13.4 3.4 5.1 7.2 1.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Rad60-SLD_2 PF13881.6 ETO24662.1 - 0.6 10.2 0.0 0.6 10.2 0.0 3.1 3 1 0 3 3 3 0 Ubiquitin-2 like Rad60 SUMO-like DUF3246 PF11596.8 ETO24662.1 - 9.1 5.6 10.1 0.31 10.4 2.3 2.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3246) Pex14_N PF04695.13 ETO24664.1 - 0.047 14.4 4.1 0.057 14.1 4.1 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region CbtA PF09490.10 ETO24664.1 - 0.05 13.4 0.7 0.058 13.2 0.7 1.2 1 0 0 1 1 1 0 Probable cobalt transporter subunit (CbtA) AP-5_subunit_s1 PF15001.6 ETO24664.1 - 0.077 13.0 1.4 0.083 12.9 1.4 1.1 1 0 0 1 1 1 0 AP-5 complex subunit sigma-1 DUF4320 PF14208.6 ETO24664.1 - 0.082 13.0 1.4 0.12 12.4 1.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4320) Mucin PF01456.17 ETO24664.1 - 0.29 11.1 16.6 0.34 10.9 16.6 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Sigma70_ner PF04546.13 ETO24664.1 - 0.48 10.3 8.3 0.62 9.9 8.3 1.3 1 1 0 1 1 1 0 Sigma-70, non-essential region PX PF00787.24 ETO24665.1 - 4.7e-14 52.3 0.4 9.8e-14 51.3 0.4 1.5 1 0 0 1 1 1 1 PX domain Kelch_4 PF13418.6 ETO24666.1 - 3.2e-18 65.4 0.3 0.00023 21.1 0.0 5.4 5 0 0 5 5 5 4 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO24666.1 - 1e-14 54.2 1.7 0.0033 17.6 0.0 6.1 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.25 ETO24666.1 - 1.8e-12 46.6 3.3 0.0056 16.2 0.0 6.3 6 1 0 6 6 6 3 Kelch motif Kelch_3 PF13415.6 ETO24666.1 - 4.3e-10 39.6 3.6 0.0059 16.9 0.0 5.3 5 1 1 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO24666.1 - 1.6e-05 24.6 0.1 1.1 9.4 0.0 4.2 4 1 0 4 4 4 2 Kelch motif PfUIS3 PF11567.8 ETO24666.1 - 0.083 13.3 0.1 1.2 9.5 0.0 2.6 2 1 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein DUF1392 PF07154.11 ETO24666.1 - 0.097 12.8 0.4 0.21 11.7 0.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1392) Auxin_inducible PF02519.14 ETO24666.1 - 0.1 12.8 0.0 7.5 6.8 0.0 2.3 2 0 0 2 2 2 0 Auxin responsive protein DUF5074 PF16819.5 ETO24666.1 - 0.3 11.1 8.8 3.5 7.7 0.6 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF5074) DUF1635 PF07795.11 ETO24667.1 - 0.35 10.7 11.0 0.099 12.5 8.0 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) OEP PF02321.18 ETO24667.1 - 0.64 9.8 7.6 1.5 8.6 7.6 1.5 1 0 0 1 1 1 0 Outer membrane efflux protein Coilin_N PF15862.5 ETO24668.1 - 0.0068 16.2 5.6 0.0068 16.2 5.6 3.7 3 1 0 3 3 3 1 Coilin N-terminus TPR_19 PF14559.6 ETO24670.1 - 0.00044 20.7 0.2 0.0008 19.9 0.2 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24670.1 - 0.0022 18.3 0.0 0.011 16.1 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO24670.1 - 0.0025 18.1 0.1 0.0059 16.9 0.1 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24670.1 - 0.0036 17.3 0.3 0.068 13.3 0.1 2.8 3 0 0 3 3 2 1 Tetratricopeptide repeat Spore_II_R PF09551.10 ETO24670.1 - 0.0054 17.2 0.6 0.012 16.0 0.6 1.6 1 0 0 1 1 1 1 Stage II sporulation protein R (spore_II_R) HDA2-3 PF11496.8 ETO24670.1 - 0.0066 15.6 1.3 0.0091 15.2 1.3 1.3 1 0 0 1 1 1 1 Class II histone deacetylase complex subunits 2 and 3 TPR_1 PF00515.28 ETO24670.1 - 0.0076 16.0 2.4 0.065 13.1 0.4 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO24670.1 - 0.013 15.8 0.8 0.035 14.3 0.8 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO24670.1 - 0.036 14.7 0.0 0.061 14.0 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat Glyco_hydro_20b PF02838.15 ETO24670.1 - 0.21 12.4 0.7 1.3 9.8 0.1 2.1 2 0 0 2 2 2 0 Glycosyl hydrolase family 20, domain 2 Cnd1 PF12717.7 ETO24670.1 - 0.27 11.3 1.8 1.6 8.7 1.6 2.1 1 1 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1 Sec7 PF01369.20 ETO24671.1 - 9.1e-63 211.2 4.2 1.9e-62 210.2 4.2 1.5 1 0 0 1 1 1 1 Sec7 domain Sialidase PF02973.16 ETO24671.1 - 0.00041 19.9 0.1 0.0012 18.3 0.1 1.8 1 0 0 1 1 1 1 Sialidase, N-terminal domain DUF3782 PF12644.7 ETO24671.1 - 0.041 14.0 0.0 0.63 10.2 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) CENP-B_dimeris PF09026.10 ETO24672.1 - 0.3 11.5 10.9 0.95 9.9 10.9 1.8 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF3452 PF11934.8 ETO24672.1 - 0.55 9.8 5.1 11 5.6 0.2 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF3452) Sporozoite_P67 PF05642.11 ETO24672.1 - 1.3 7.0 4.9 2.2 6.3 4.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Homeobox_KN PF05920.11 ETO24673.1 - 3e-14 52.6 0.3 4.9e-14 52.0 0.3 1.3 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ETO24673.1 - 5.4e-09 35.8 0.7 9.5e-09 35.0 0.7 1.4 1 0 0 1 1 1 1 Homeodomain TMEM154 PF15102.6 ETO24674.1 - 1.3 9.0 3.8 17 5.3 0.8 2.1 2 0 0 2 2 2 0 TMEM154 protein family DUF4246 PF14033.6 ETO24677.1 - 3.6e-93 313.2 9.2 2.3e-49 168.7 0.3 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) 2OG-FeII_Oxy_5 PF13759.6 ETO24677.1 - 0.00011 22.5 0.1 0.00045 20.6 0.1 2.0 1 0 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase G-alpha PF00503.20 ETO24678.1 - 2.9e-43 148.4 3.8 3.8e-43 148.0 3.8 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO24678.1 - 6.9e-07 28.9 0.2 1.9e-06 27.5 0.1 1.7 2 0 0 2 2 2 1 ADP-ribosylation factor family Kelch_6 PF13964.6 ETO24679.1 - 0.00042 20.5 0.2 0.0047 17.2 0.1 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO24679.1 - 0.002 17.7 0.1 0.059 13.0 0.1 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO24679.1 - 0.009 16.0 0.5 0.12 12.4 0.0 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO24679.1 - 0.018 15.3 0.0 0.38 11.1 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO24679.1 - 0.046 13.7 0.5 1.1 9.4 0.1 2.9 3 0 0 3 3 3 0 Kelch motif G-alpha PF00503.20 ETO24680.1 - 4.1e-18 65.7 7.9 1.6e-16 60.4 7.9 2.1 1 1 0 1 1 1 1 G-protein alpha subunit LAGLIDADG_1 PF00961.19 ETO24680.1 - 0.036 15.0 0.9 0.071 14.1 0.1 1.9 2 0 0 2 2 2 0 LAGLIDADG endonuclease Pkinase PF00069.25 ETO24681.1 - 1.5e-52 178.6 0.0 1.2e-43 149.4 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24681.1 - 2.5e-24 86.0 0.0 1.7e-21 76.7 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO24681.1 - 0.016 14.5 0.0 0.03 13.7 0.0 1.4 1 1 0 1 1 1 0 Kinase-like Haspin_kinase PF12330.8 ETO24681.1 - 0.019 14.0 0.0 0.16 10.9 0.0 2.1 2 1 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 ETO24681.1 - 0.14 12.0 0.0 0.56 10.1 0.0 1.7 1 1 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO24681.1 - 0.15 10.8 0.1 0.42 9.3 0.0 1.7 2 0 0 2 2 2 0 Fungal protein kinase Sulfate_transp PF00916.20 ETO24682.1 - 3.2e-35 121.6 7.0 4e-35 121.3 7.0 1.0 1 0 0 1 1 1 1 Sulfate permease family CbiQ PF02361.16 ETO24682.1 - 0.0088 15.7 6.9 0.069 12.8 0.4 2.2 2 0 0 2 2 2 2 Cobalt transport protein RhodobacterPufX PF11511.8 ETO24682.1 - 1 9.0 6.6 4.4 7.0 0.2 2.8 3 0 0 3 3 3 0 Intrinsic membrane protein PufX MARVEL PF01284.23 ETO24682.1 - 2.3 8.3 13.4 2.2 8.3 11.8 1.7 1 1 1 2 2 2 0 Membrane-associating domain Tafi-CsgC PF10610.9 ETO24683.1 - 0.072 13.3 0.2 0.12 12.6 0.2 1.3 1 0 0 1 1 1 0 Thin aggregative fimbriae synthesis protein FERM_N PF09379.10 ETO24685.1 - 0.11 12.4 0.1 0.22 11.5 0.1 1.5 1 0 0 1 1 1 0 FERM N-terminal domain DUF2207 PF09972.9 ETO24686.1 - 0.0022 16.9 0.7 0.0037 16.1 0.7 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) NFRKB_winged PF14465.6 ETO24687.1 - 0.017 15.3 0.2 0.023 14.9 0.2 1.2 1 0 0 1 1 1 0 NFRKB Winged Helix-like Orf78 PF06024.12 ETO24687.1 - 0.93 9.8 8.8 0.11 12.8 3.1 1.9 1 1 1 2 2 2 0 Orf78 (ac78) JUPITER PF17054.5 ETO24688.1 - 0.05 13.1 3.0 0.093 12.2 3.0 1.3 1 0 0 1 1 1 0 Microtubule-Associated protein Jupiter Kinesin PF00225.23 ETO24689.1 - 3.6e-59 200.4 12.8 3.1e-47 161.1 5.3 2.2 2 0 0 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ETO24689.1 - 1.1e-08 35.2 2.7 0.00078 19.4 0.3 2.6 2 0 0 2 2 2 2 Microtubule binding CAP_GLY PF01302.25 ETO24690.1 - 5.6e-19 67.9 0.0 7.9e-19 67.4 0.0 1.2 1 0 0 1 1 1 1 CAP-Gly domain MAGE PF01454.19 ETO24690.1 - 0.0025 17.5 0.1 0.0043 16.8 0.1 1.5 2 0 0 2 2 2 1 MAGE family TPR_12 PF13424.6 ETO24693.1 - 3.9e-150 488.5 54.7 1.7e-18 66.7 2.2 10.3 6 1 5 11 11 11 11 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24693.1 - 5.3e-117 379.0 29.0 3e-10 39.6 0.0 16.8 16 1 1 17 17 17 16 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24693.1 - 6.4e-106 342.3 117.4 8.3e-09 34.9 0.4 17.2 16 1 0 16 16 16 16 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24693.1 - 1.3e-85 274.7 87.8 8e-07 28.7 0.5 16.7 16 1 0 16 16 16 16 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24693.1 - 7e-75 241.7 32.1 1.8e-05 24.4 0.0 16.3 16 0 0 16 16 16 15 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24693.1 - 1.8e-72 233.6 115.1 8.1e-07 28.8 0.4 17.5 17 1 0 17 17 17 15 Tetratricopeptide repeat TPR_16 PF13432.6 ETO24693.1 - 9.3e-31 106.2 0.0 0.0037 17.9 0.0 12.4 10 4 3 13 13 13 7 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24693.1 - 9.5e-31 104.4 30.2 0.14 12.9 0.2 15.8 16 0 0 16 16 16 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24693.1 - 1.3e-29 100.3 0.0 0.52 11.3 0.0 15.5 16 0 0 16 16 16 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24693.1 - 1.6e-25 87.6 46.5 0.022 15.1 0.2 15.5 14 1 0 14 14 14 7 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24693.1 - 9.6e-21 73.2 120.6 0.006 16.2 0.2 19.1 15 4 4 19 19 19 10 TPR repeat ANAPC3 PF12895.7 ETO24693.1 - 1.6e-14 53.8 59.2 0.02 15.1 1.5 9.8 7 2 1 9 9 9 7 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO24693.1 - 2.1e-09 37.8 15.7 0.42 11.1 0.1 8.5 8 2 1 10 10 9 3 Tetratricopeptide repeat MIT PF04212.18 ETO24693.1 - 3.1e-08 33.6 68.9 0.11 12.6 0.6 15.6 13 2 3 16 16 16 3 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO24693.1 - 3.5e-08 32.8 29.9 0.31 10.5 0.1 12.5 14 0 0 14 14 14 3 SHNi-TPR PPR PF01535.20 ETO24693.1 - 1.1e-06 28.5 27.6 1.9 8.9 0.0 12.5 13 0 0 13 13 13 1 PPR repeat DUF5113 PF17140.4 ETO24693.1 - 0.00036 20.4 85.5 1.6 8.5 0.5 15.2 11 4 4 15 15 15 5 Domain of unknown function (DUF5113) mit_SMPDase PF14724.6 ETO24693.1 - 0.00041 18.5 12.5 0.053 11.5 0.1 5.0 2 2 3 6 6 6 2 Mitochondrial-associated sphingomyelin phosphodiesterase TPR_9 PF13371.6 ETO24693.1 - 0.00053 20.1 0.0 29 4.9 0.0 6.5 9 0 0 9 9 8 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO24693.1 - 0.0019 18.8 41.7 29 5.5 0.0 13.0 15 0 0 15 15 13 0 Sel1 repeat HTH_Bact PF18768.1 ETO24693.1 - 0.0021 17.6 50.0 14 5.4 0.0 14.8 15 0 0 15 15 15 0 Helix-turn-helix bacterial domain SPO22 PF08631.10 ETO24693.1 - 0.0022 17.5 38.0 0.29 10.6 0.3 8.3 4 2 2 6 6 6 3 Meiosis protein SPO22/ZIP4 like YflT PF11181.8 ETO24693.1 - 0.16 12.5 24.7 1.5 9.4 0.1 7.1 5 2 5 10 10 10 0 Heat induced stress protein YflT MMPL PF03176.15 ETO24693.1 - 2.2 7.2 3.1 3.3 6.5 3.1 1.2 1 0 0 1 1 1 0 MMPL family Kelch_4 PF13418.6 ETO24694.1 - 9.6e-07 28.7 0.3 0.0033 17.4 0.0 3.8 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24694.1 - 1.9e-06 27.4 4.3 0.02 14.5 0.9 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO24694.1 - 4.4e-05 23.6 4.1 5.5 7.4 0.0 4.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO24694.1 - 6.8e-05 22.7 2.7 0.0035 17.3 0.3 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO24694.1 - 0.083 13.2 0.3 4 7.8 0.0 3.6 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24695.1 - 7.8e-07 28.6 0.4 0.46 10.1 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO24695.1 - 1.8e-05 24.7 1.3 0.0069 16.4 0.1 3.5 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO24695.1 - 7.8e-05 22.8 4.1 2.3 8.6 0.0 4.7 3 1 1 4 4 4 3 Kelch motif Kelch_5 PF13854.6 ETO24695.1 - 0.38 10.8 2.4 8.8 6.4 0.0 3.9 5 0 0 5 5 5 0 Kelch motif Kelch_2 PF07646.15 ETO24695.1 - 0.5 10.4 6.2 5.5 7.1 1.2 3.9 4 1 0 4 4 4 0 Kelch motif MFS_5 PF05631.14 ETO24696.1 - 6.7e-25 87.8 0.4 1e-24 87.1 0.4 1.4 1 0 0 1 1 1 1 Sugar-tranasporters, 12 TM MFS_1 PF07690.16 ETO24696.1 - 0.00013 21.0 0.8 0.00013 21.0 0.8 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily FOP_dimer PF09398.10 ETO24697.1 - 0.079 13.2 0.7 0.38 11.0 0.1 2.1 2 0 0 2 2 2 0 FOP N terminal dimerisation domain WD40 PF00400.32 ETO24698.1 - 0.0081 17.0 0.2 0.027 15.4 0.2 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF4834 PF16118.5 ETO24699.1 - 0.046 14.7 0.1 0.78 10.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) PNP_UDP_1 PF01048.20 ETO24700.1 - 0.00012 21.5 0.0 0.23 10.7 0.0 2.1 1 1 1 2 2 2 2 Phosphorylase superfamily AA_permease_2 PF13520.6 ETO24702.1 - 1.8e-43 148.9 40.5 2.3e-43 148.6 40.5 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETO24702.1 - 1.1e-33 116.6 36.9 1.5e-33 116.1 36.9 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3087 PF11286.8 ETO24702.1 - 4.9 6.6 6.4 0.68 9.4 1.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3087) TPR_12 PF13424.6 ETO24703.1 - 7.2e-25 87.1 5.4 1.5e-11 44.4 0.3 3.4 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24703.1 - 4.6e-18 64.5 0.3 0.00045 20.0 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24703.1 - 6e-16 57.2 15.8 3.4e-05 23.6 0.3 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24703.1 - 3e-13 48.8 19.8 0.00021 21.3 0.7 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24703.1 - 3.7e-12 45.5 24.0 3e-06 26.8 0.8 4.9 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24703.1 - 1.1e-06 28.2 6.9 0.5 10.5 0.0 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24703.1 - 0.00045 20.7 9.1 1.1 10.0 0.0 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO24703.1 - 0.0015 19.1 2.2 0.055 14.1 0.5 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO24703.1 - 0.0035 17.3 0.1 0.006 16.6 0.1 1.4 1 0 0 1 1 1 1 Caspase domain DUF2225 PF09986.9 ETO24703.1 - 0.0047 16.7 5.9 0.034 13.9 4.3 2.5 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 ETO24703.1 - 0.0079 16.2 15.9 0.16 12.0 0.7 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24703.1 - 0.012 15.9 3.2 0.34 11.4 0.1 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24703.1 - 0.014 16.2 0.1 17 6.5 0.0 3.8 5 0 0 5 5 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24703.1 - 0.065 12.9 0.2 0.065 12.9 0.2 3.8 4 1 1 5 5 4 0 TPR repeat Rab3-GTPase_cat PF13890.6 ETO24703.1 - 0.11 12.2 0.1 0.21 11.2 0.1 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit MIT PF04212.18 ETO24703.1 - 0.16 12.1 6.8 1.3 9.1 0.1 4.1 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO24703.1 - 0.22 11.8 5.9 3.9 7.8 0.6 3.2 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 NnrS PF05940.12 ETO24704.1 - 0.034 13.5 0.3 0.034 13.5 0.3 2.2 1 1 0 2 2 2 0 NnrS protein PgaD PF13994.6 ETO24704.1 - 2.8 8.0 8.8 0.17 11.9 1.1 2.4 2 1 1 3 3 3 0 PgaD-like protein Clathrin_H_link PF13838.6 ETO24705.1 - 0.012 15.5 0.4 0.032 14.1 0.0 1.8 2 0 0 2 2 2 0 Clathrin-H-link SPC25 PF06703.11 ETO24706.1 - 0.015 15.1 6.4 0.019 14.8 6.4 1.1 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) DUF4131 PF13567.6 ETO24706.1 - 0.029 14.0 0.1 0.032 13.9 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) DUF4834 PF16118.5 ETO24706.1 - 3.3 8.7 8.3 0.1 13.6 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Holin_BhlA PF10960.8 ETO24707.1 - 0.025 14.5 2.4 0.53 10.3 0.1 2.2 2 0 0 2 2 2 0 BhlA holin family PspB PF06667.12 ETO24707.1 - 0.049 13.7 0.3 0.13 12.3 0.1 1.7 2 0 0 2 2 2 0 Phage shock protein B DUF460 PF04312.13 ETO24708.1 - 0.018 14.7 0.0 0.025 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF460) MutS_V PF00488.21 ETO24709.1 - 2.5e-08 34.2 0.0 1.7e-07 31.5 0.0 1.9 1 1 0 1 1 1 1 MutS domain V MCRS_N PF13325.6 ETO24709.1 - 0.00062 19.8 0.3 0.001 19.1 0.3 1.3 1 0 0 1 1 1 1 N-terminal region of micro-spherule protein Ank_4 PF13637.6 ETO24711.1 - 0.067 13.8 0.0 0.18 12.4 0.0 1.7 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Omptin PF01278.20 ETO24711.1 - 0.077 12.0 5.1 0.13 11.3 5.1 1.3 1 0 0 1 1 1 0 Omptin family SelP_N PF04592.14 ETO24711.1 - 2.1 7.7 8.4 3.9 6.8 8.4 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region AAA_22 PF13401.6 ETO24712.1 - 0.0062 16.8 0.0 0.038 14.3 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA PF00004.29 ETO24712.1 - 0.034 14.6 0.0 1.7 9.1 0.0 3.4 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO24712.1 - 0.089 12.3 1.6 0.41 10.2 0.1 2.6 2 1 0 2 2 2 0 P-loop containing dynein motor region TubC_N PF18563.1 ETO24712.1 - 3.1 7.8 5.2 13 5.9 0.7 2.9 2 0 0 2 2 2 0 TubC N-terminal docking domain zf-TRAF PF02176.18 ETO24714.1 - 9e-06 26.3 3.3 9e-06 26.3 3.3 2.8 2 1 1 3 3 3 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETO24714.1 - 0.0082 16.0 3.0 0.0082 16.0 3.0 3.5 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) TPR_2 PF07719.17 ETO24715.1 - 1.6e-09 37.1 0.6 5.1e-09 35.6 0.6 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24715.1 - 2.4e-09 36.6 1.8 4.2e-09 35.8 0.9 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24715.1 - 3.6e-07 29.9 2.5 8.1e-07 28.8 0.3 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24715.1 - 6.5e-07 28.9 0.1 1.5e-06 27.8 0.1 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24715.1 - 5e-06 26.7 0.4 3e-05 24.2 0.1 2.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24715.1 - 0.0057 17.4 0.0 0.017 15.9 0.0 1.8 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24715.1 - 0.0079 16.8 0.1 0.028 15.1 0.1 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24715.1 - 0.019 14.7 0.9 0.019 14.7 0.9 2.4 3 1 0 3 3 3 0 TPR repeat TPR_16 PF13432.6 ETO24715.1 - 0.021 15.4 0.0 0.036 14.7 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24715.1 - 0.023 14.6 0.3 0.061 13.2 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PseudoU_synth_2 PF00849.22 ETO24715.1 - 0.41 10.7 6.3 0.069 13.2 1.6 2.2 1 1 1 2 2 2 0 RNA pseudouridylate synthase Presenilin PF01080.17 ETO24715.1 - 0.83 8.4 7.4 1.5 7.5 7.4 1.4 1 0 0 1 1 1 0 Presenilin OB_NTP_bind PF07717.16 ETO24715.1 - 1.5 9.2 7.2 8.9 6.7 7.2 2.1 1 1 0 1 1 1 0 Oligonucleotide/oligosaccharide-binding (OB)-fold TPR_12 PF13424.6 ETO24716.1 - 1.2e-39 134.5 0.0 2.1e-13 50.4 0.0 4.3 2 2 2 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24716.1 - 9.2e-26 87.9 17.4 0.00061 19.8 0.2 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24716.1 - 3.8e-22 76.5 7.2 0.00049 20.0 0.2 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24716.1 - 1.2e-17 62.9 14.6 0.00049 19.8 0.3 6.6 6 1 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24716.1 - 1.5e-16 59.1 0.1 0.0026 17.7 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24716.1 - 4.8e-15 54.9 0.0 0.73 9.8 0.0 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO24716.1 - 1.4e-12 48.2 0.3 3.7e-12 46.7 0.3 1.7 1 0 0 1 1 1 1 Caspase domain TPR_MalT PF17874.1 ETO24716.1 - 5.6e-10 39.1 0.0 1.3e-06 28.0 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region TPR_6 PF13174.6 ETO24716.1 - 1.7e-07 31.4 0.8 1.1 10.0 0.0 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24716.1 - 5.8e-06 26.3 1.6 10 6.8 0.0 5.7 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO24716.1 - 5.8e-05 23.7 0.0 0.042 14.5 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24716.1 - 6.9e-05 23.3 0.0 25 6.1 0.0 4.7 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 ETO24716.1 - 0.00012 21.9 0.4 0.68 9.6 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat-like domain DUF5113 PF17140.4 ETO24716.1 - 0.00012 21.9 6.8 0.024 14.4 2.5 4.1 2 1 2 4 4 4 1 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO24716.1 - 0.00071 19.2 6.2 0.86 9.3 0.3 5.0 5 0 0 5 5 5 1 TPR repeat DUF4810 PF16068.5 ETO24716.1 - 0.0038 17.7 4.0 5.9 7.5 0.0 5.1 4 1 0 4 4 4 1 Domain of unknown function (DUF4810) ANAPC3 PF12895.7 ETO24716.1 - 0.016 15.5 1.7 0.3 11.4 0.0 3.3 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO24716.1 - 8.2 6.5 11.6 0.24 11.5 0.5 3.3 4 0 0 4 4 2 0 Tetratricopeptide repeat WD40 PF00400.32 ETO24717.1 - 1.2e-20 73.4 11.7 8.1e-06 26.5 0.9 4.4 4 1 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24717.1 - 8.7e-06 25.9 0.0 0.11 12.8 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO24717.1 - 0.029 13.7 0.0 0.21 10.9 0.0 2.0 1 1 1 2 2 2 0 WD40-like domain AidB_N PF18158.1 ETO24718.1 - 1.4e-10 41.3 0.0 2e-10 40.8 0.0 1.1 1 0 0 1 1 1 1 Adaptive response protein AidB N-terminal domain UBA PF00627.31 ETO24719.1 - 7.2e-05 22.6 0.2 0.00029 20.7 0.1 2.0 2 0 0 2 2 2 1 UBA/TS-N domain FliJ PF02050.16 ETO24721.1 - 0.0061 16.8 1.3 0.0089 16.2 1.1 1.4 1 1 0 1 1 1 1 Flagellar FliJ protein PEX11 PF05648.14 ETO24721.1 - 0.071 12.6 0.3 0.1 12.1 0.3 1.2 1 0 0 1 1 1 0 Peroxisomal biogenesis factor 11 (PEX11) AKNA PF12443.8 ETO24722.1 - 0.0034 18.0 4.9 0.0034 18.0 4.9 2.7 1 1 2 3 3 3 1 AT-hook-containing transcription factor SOGA PF11365.8 ETO24722.1 - 0.0043 18.2 7.0 0.0043 18.2 7.0 2.2 2 0 0 2 2 2 1 Protein SOGA FlxA PF14282.6 ETO24722.1 - 0.091 12.8 16.9 0.26 11.3 6.8 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF948 PF06103.11 ETO24722.1 - 0.14 12.5 2.4 9 6.6 0.1 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Filament PF00038.21 ETO24722.1 - 0.16 11.6 17.4 5.9 6.4 17.7 2.1 1 1 1 2 2 2 0 Intermediate filament protein Spc7 PF08317.11 ETO24722.1 - 0.31 9.9 17.8 0.22 10.4 7.3 2.0 2 0 0 2 2 2 0 Spc7 kinetochore protein Vir_act_alpha_C PF10400.9 ETO24722.1 - 0.81 10.4 8.1 1.8 9.3 2.7 2.5 2 1 0 2 2 2 0 Virulence activator alpha C-term tRNA-synt_1c PF00749.21 ETO24722.1 - 0.97 8.3 5.2 0.7 8.7 4.0 1.3 1 1 0 1 1 1 0 tRNA synthetases class I (E and Q), catalytic domain Ribosomal_S7e PF01251.18 ETO24722.1 - 1 9.1 11.0 0.051 13.3 4.3 2.0 2 1 0 2 2 2 0 Ribosomal protein S7e DivIC PF04977.15 ETO24722.1 - 1.4 8.8 19.7 0.5 10.2 2.5 3.4 1 1 2 3 3 3 0 Septum formation initiator UPF0449 PF15136.6 ETO24722.1 - 1.5 9.4 11.2 3.7 8.1 0.5 2.6 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 Mod_r PF07200.13 ETO24722.1 - 1.6 8.9 24.3 0.056 13.5 11.5 2.1 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Prefoldin PF02996.17 ETO24722.1 - 3.5 7.6 17.7 1.4 8.8 4.4 3.0 2 1 1 3 3 3 0 Prefoldin subunit YabA PF06156.13 ETO24722.1 - 3.5 8.3 17.3 6.2 7.5 3.5 3.0 2 1 1 3 3 3 0 Initiation control protein YabA PVL_ORF50 PF07768.11 ETO24722.1 - 4.7 7.5 8.3 0.69 10.2 3.3 2.0 1 1 1 2 2 2 0 PVL ORF-50-like family DUF4407 PF14362.6 ETO24722.1 - 4.9 6.4 9.8 21 4.4 0.3 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Allexi_40kDa PF05549.11 ETO24722.1 - 6.5 6.2 10.7 3.6 7.0 3.0 2.1 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF2381 PF09544.10 ETO24722.1 - 7.5 6.0 7.6 8.1 5.9 1.9 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2381) TnpV PF14198.6 ETO24723.1 - 0.0053 16.7 1.7 0.29 11.1 0.2 2.2 1 1 1 2 2 2 2 Transposon-encoded protein TnpV HOIP-UBA PF16678.5 ETO24723.1 - 0.021 14.8 0.2 2.7 8.0 0.0 2.2 1 1 1 2 2 2 0 HOIP UBA domain pair HTH_57 PF18679.1 ETO24723.1 - 0.067 13.5 0.7 10 6.5 0.1 2.2 1 1 1 2 2 2 0 ThcOx helix turn helix domain Bap31_Bap29_C PF18035.1 ETO24723.1 - 0.075 13.1 1.0 0.2 11.7 1.0 1.9 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Pkinase PF00069.25 ETO24724.1 - 1.4e-18 67.2 0.0 5.2e-18 65.4 0.0 1.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24724.1 - 1e-05 25.0 0.0 0.085 12.1 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Ycf70 PF17382.2 ETO24724.1 - 0.089 13.2 1.2 0.089 13.2 1.2 2.5 2 0 0 2 2 2 0 Uncharacterized Ycf70-like Mtc PF03820.17 ETO24725.1 - 0.09 11.8 1.5 0.099 11.7 1.5 1.0 1 0 0 1 1 1 0 Tricarboxylate carrier PPR_2 PF13041.6 ETO24726.1 - 3e-12 46.5 7.8 9.3e-06 25.7 0.9 4.9 4 1 1 5 5 5 3 PPR repeat family PPR PF01535.20 ETO24726.1 - 1.5e-11 43.7 5.7 0.0086 16.3 0.0 5.2 5 0 0 5 5 5 3 PPR repeat PPR_3 PF13812.6 ETO24726.1 - 3e-06 27.2 0.9 0.0019 18.2 0.0 3.5 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO24726.1 - 8.1e-06 25.4 0.4 0.0055 16.4 0.0 3.3 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 ETO24726.1 - 1.5e-05 24.5 1.3 5.5e-05 22.6 1.3 2.0 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO24726.1 - 0.00065 19.5 0.1 0.0018 18.1 0.1 1.8 1 0 0 1 1 1 1 Mitochondrial ATPase expression DASH_Ask1 PF08655.10 ETO24727.1 - 0.0079 16.1 0.0 0.021 14.7 0.0 1.7 2 0 0 2 2 2 1 DASH complex subunit Ask1 UPF0113_N PF17833.1 ETO24728.1 - 0.014 15.9 0.1 0.04 14.5 0.1 1.7 1 0 0 1 1 1 0 UPF0113 Pre-PUA domain GCP_C_terminal PF04130.13 ETO24729.1 - 1.3e-26 93.8 10.7 1.6e-26 93.5 10.7 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ETO24730.1 - 0.00074 19.2 0.2 0.0011 18.7 0.2 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal GCP_C_terminal PF04130.13 ETO24730.1 - 0.0018 17.8 0.1 0.0027 17.2 0.1 1.3 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal WD40 PF00400.32 ETO24732.1 - 2.1e-06 28.3 2.9 0.11 13.4 0.1 4.5 4 0 0 4 4 4 2 WD domain, G-beta repeat RabGAP-TBC PF00566.18 ETO24733.1 - 1.7e-23 83.4 1.6 1.7e-23 83.4 1.6 5.2 4 1 0 4 4 4 2 Rab-GTPase-TBC domain zf-U11-48K PF05253.12 ETO24734.1 - 5.4 7.1 5.7 29 4.7 0.2 3.7 4 0 0 4 4 4 0 U11-48K-like CHHC zinc finger Ank_2 PF12796.7 ETO24735.1 - 3.8e-10 40.2 3.5 0.00023 21.7 0.1 2.9 1 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO24735.1 - 1.9e-09 37.8 1.1 0.0016 19.0 0.0 4.1 2 2 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO24735.1 - 0.0012 19.2 2.8 0.027 15.0 0.1 4.0 5 0 0 5 5 5 1 Ankyrin repeat DUF1843 PF08898.10 ETO24735.1 - 0.022 15.2 0.0 0.056 13.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1843) Ank PF00023.30 ETO24735.1 - 0.15 12.6 5.2 0.75 10.4 0.1 3.9 4 1 0 4 4 4 0 Ankyrin repeat DUF3439 PF11921.8 ETO24736.1 - 2.3 8.2 8.9 7.1 6.6 8.9 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Glyco_transf_18 PF15024.6 ETO24737.1 - 1.3e-10 40.5 0.0 2.4e-10 39.7 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase family 18 GTP_EFTU PF00009.27 ETO24738.1 - 4.4e-27 94.9 0.1 6.9e-27 94.3 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETO24738.1 - 6e-07 29.8 0.0 1.8e-06 28.2 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain RsgA_GTPase PF03193.16 ETO24738.1 - 0.002 18.1 0.3 0.027 14.4 0.1 2.4 2 0 0 2 2 2 1 RsgA GTPase ATP_bind_1 PF03029.17 ETO24738.1 - 0.0033 17.2 0.1 0.27 11.0 0.1 3.1 2 1 0 2 2 2 1 Conserved hypothetical ATP binding protein AAA_18 PF13238.6 ETO24738.1 - 0.0035 17.9 0.0 0.0081 16.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain MMR_HSR1 PF01926.23 ETO24738.1 - 0.0097 16.0 0.0 0.093 12.8 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase PduV-EutP PF10662.9 ETO24738.1 - 0.028 14.2 0.0 0.19 11.5 0.0 2.2 1 1 1 2 2 2 0 Ethanolamine utilisation - propanediol utilisation GTP_EFTU_D2 PF03144.25 ETO24738.1 - 0.032 14.6 0.2 0.29 11.5 0.1 2.6 3 0 0 3 3 3 0 Elongation factor Tu domain 2 AAA_17 PF13207.6 ETO24738.1 - 0.062 13.7 0.0 0.15 12.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Pkinase PF00069.25 ETO24739.1 - 1.3e-19 70.6 1.5 3e-18 66.2 1.5 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24739.1 - 9.9e-13 48.0 0.8 3.8e-11 42.8 0.8 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO24741.1 - 4.8e-40 137.6 0.1 4.8e-40 137.6 0.1 1.8 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24741.1 - 2.3e-10 40.2 1.3 4.5e-10 39.2 0.1 2.1 2 1 0 2 2 2 1 Protein tyrosine kinase NOA36 PF06524.12 ETO24741.1 - 2.2 7.5 12.8 3.1 7.1 12.8 1.1 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO24741.1 - 7.2 5.3 7.4 9.6 4.8 7.4 1.2 1 0 0 1 1 1 0 Presenilin SCAPER_N PF16501.5 ETO24742.1 - 0.04 13.9 0.2 0.11 12.5 0.2 1.8 1 0 0 1 1 1 0 S phase cyclin A-associated protein in the endoplasmic reticulum GlcV_C_terminal PF17847.1 ETO24742.1 - 0.057 13.9 0.1 0.29 11.6 0.1 2.3 1 0 0 1 1 1 0 Glucose ABC transporter C-terminal domain EphA2_TM PF14575.6 ETO24742.1 - 1.2 10.0 3.7 1 10.3 0.1 2.7 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain ALMT PF11744.8 ETO24743.1 - 6.7 5.4 11.4 2.2 7.0 1.3 2.0 2 0 0 2 2 2 0 Aluminium activated malate transporter HgmA PF04209.13 ETO24744.1 - 2.1e-76 257.3 0.0 2.6e-76 257.1 0.0 1.0 1 0 0 1 1 1 1 homogentisate 1,2-dioxygenase Sulfate_transp PF00916.20 ETO24745.1 - 2.4e-17 62.8 20.5 3.4e-09 35.9 4.9 3.4 3 1 0 3 3 3 3 Sulfate permease family CarbpepA_inh PF02977.15 ETO24745.1 - 0.15 11.8 0.1 0.28 11.0 0.1 1.4 1 0 0 1 1 1 0 Carboxypeptidase A inhibitor WD40 PF00400.32 ETO24746.1 - 8.1e-07 29.7 0.7 0.13 13.2 0.0 4.8 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24746.1 - 0.017 15.4 0.0 1.1 9.6 0.0 3.7 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain POX PF07526.11 ETO24747.1 - 0.8 10.3 4.7 3.6 8.1 0.9 2.8 2 0 0 2 2 2 0 Associated with HOX Presenilin PF01080.17 ETO24747.1 - 2 7.1 10.0 0.012 14.4 1.8 1.5 2 0 0 2 2 2 0 Presenilin Ferlin_C PF16165.5 ETO24747.1 - 2.3 8.2 5.1 0.81 9.6 1.4 2.0 2 0 0 2 2 2 0 Ferlin C-terminus GOLD_2 PF13897.6 ETO24747.1 - 3.1 8.3 5.0 3.5 8.1 0.5 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking XPG_I PF00867.18 ETO24747.1 - 6.7 7.1 7.9 0.26 11.6 0.4 2.4 2 0 0 2 2 2 0 XPG I-region Ndufs5 PF10200.9 ETO24748.1 - 0.2 11.9 2.0 28 5.1 0.0 3.1 3 0 0 3 3 3 0 NADH:ubiquinone oxidoreductase, NDUFS5-15kDa TMF_TATA_bd PF12325.8 ETO24748.1 - 2.4 8.4 5.0 2.1 8.6 1.3 2.5 3 0 0 3 3 3 0 TATA element modulatory factor 1 TATA binding START PF01852.19 ETO24750.1 - 0.011 15.2 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 0 START domain Hist_deacetyl PF00850.19 ETO24751.1 - 9.3e-62 209.2 0.2 1.1e-61 209.0 0.2 1.0 1 0 0 1 1 1 1 Histone deacetylase domain VID27_N PF17748.1 ETO24752.1 - 0.0043 16.9 0.1 0.006 16.5 0.1 1.2 1 0 0 1 1 1 1 VID27 N-terminal region TRP PF06011.12 ETO24753.1 - 0.00093 18.0 5.3 0.00093 18.0 5.3 1.0 1 0 0 1 1 1 1 Transient receptor potential (TRP) ion channel DUF5385 PF17359.2 ETO24753.1 - 0.0017 17.9 1.7 0.0017 17.9 1.7 1.5 2 0 0 2 2 2 1 Family of unknown function (DUF5385) DUF3404 PF11884.8 ETO24753.1 - 0.014 14.6 1.6 0.019 14.2 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3404) Tissue_fac PF01108.17 ETO24753.1 - 0.053 13.4 0.5 0.39 10.6 0.0 2.1 2 0 0 2 2 2 0 Tissue factor Gp58 PF07902.11 ETO24753.1 - 0.13 10.5 1.7 0.17 10.2 1.7 1.1 1 0 0 1 1 1 0 gp58-like protein DUF4834 PF16118.5 ETO24753.1 - 2.1 9.3 6.8 0.28 12.2 1.9 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) TMEM208_SND2 PF05620.11 ETO24753.1 - 3.6 7.4 9.7 1.2 8.9 0.2 2.1 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 FH2 PF02181.23 ETO24754.1 - 6.7e-67 226.2 17.5 6.7e-67 226.2 17.5 2.1 1 1 1 2 2 2 1 Formin Homology 2 Domain Zip PF02535.22 ETO24754.1 - 2 7.6 4.0 1.5 8.0 0.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter ATG27 PF09451.10 ETO24755.1 - 2.7e-09 37.3 4.7 8.4e-09 35.7 4.7 1.8 1 1 0 1 1 1 1 Autophagy-related protein 27 CIMR PF00878.18 ETO24755.1 - 0.00037 20.6 5.6 0.0052 16.9 0.3 2.5 2 0 0 2 2 2 2 Cation-independent mannose-6-phosphate receptor repeat SpoIIIAH PF12685.7 ETO24755.1 - 0.00084 19.2 0.5 0.0013 18.6 0.5 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein RIFIN PF02009.16 ETO24755.1 - 0.0022 18.0 0.6 0.014 15.3 0.0 2.0 2 0 0 2 2 2 1 Rifin CD34_antigen PF06365.12 ETO24755.1 - 0.01 15.4 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF3290 PF11694.8 ETO24755.1 - 0.15 12.1 1.4 0.17 11.8 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) Endomucin PF07010.12 ETO24755.1 - 1.3 9.0 9.2 0.13 12.2 1.3 2.2 2 0 0 2 2 2 0 Endomucin Orf78 PF06024.12 ETO24755.1 - 2.1 8.7 5.1 7.6 6.9 0.0 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Sigma70_ner PF04546.13 ETO24757.1 - 0.00064 19.7 5.7 0.00091 19.2 5.7 1.1 1 0 0 1 1 1 1 Sigma-70, non-essential region Cwf_Cwc_15 PF04889.12 ETO24757.1 - 0.16 11.7 14.9 0.22 11.2 14.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein RRN3 PF05327.11 ETO24757.1 - 0.19 10.2 6.3 0.24 9.9 6.3 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Neuraminidase PF18413.1 ETO24757.1 - 0.19 11.3 3.1 0.48 10.0 3.1 1.7 1 1 0 1 1 1 0 Neuraminidase-like domain CobT PF06213.12 ETO24757.1 - 0.3 10.4 6.3 0.37 10.1 6.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Rhabdo_ncap PF00945.18 ETO24757.1 - 0.68 8.8 9.7 4 6.2 8.1 2.0 2 0 0 2 2 2 0 Rhabdovirus nucleocapsid protein FAM176 PF14851.6 ETO24757.1 - 0.97 9.1 6.5 1.7 8.3 6.5 1.4 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO24757.1 - 1.3 8.3 19.0 2.4 7.4 19.0 1.4 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO24757.1 - 1.5 6.9 16.2 1.8 6.5 16.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO24757.1 - 2.2 6.4 12.5 2.7 6.1 12.5 1.1 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ETO24757.1 - 2.5 8.2 11.4 3.3 7.8 11.4 1.1 1 0 0 1 1 1 0 YL1 nuclear protein RXT2_N PF08595.11 ETO24757.1 - 9 6.3 14.2 12 6.0 13.3 1.6 2 0 0 2 2 2 0 RXT2-like, N-terminal Dyp_perox PF04261.12 ETO24758.1 - 7.3e-05 21.9 0.1 0.00035 19.7 0.0 2.0 2 1 0 2 2 2 1 Dyp-type peroxidase family Peptidase_C21 PF05381.12 ETO24758.1 - 0.01 16.2 0.0 0.019 15.3 0.0 1.5 1 0 0 1 1 1 0 Tymovirus endopeptidase Retrotran_gag_3 PF14244.6 ETO24758.1 - 0.047 13.5 0.3 0.15 11.9 0.3 1.9 1 1 0 1 1 1 0 gag-polypeptide of LTR copia-type Cnd1 PF12717.7 ETO24759.1 - 4e-43 147.3 6.6 3.8e-42 144.1 2.0 3.0 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Adaptin_N PF01602.20 ETO24759.1 - 4.8e-06 25.4 0.4 9.1e-06 24.5 0.3 1.4 1 1 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 ETO24759.1 - 1.5e-05 25.3 0.1 3.5e-05 24.1 0.1 1.6 1 0 0 1 1 1 1 HEAT repeats HEAT PF02985.22 ETO24759.1 - 2.8e-05 24.0 0.0 0.4 11.1 0.0 2.9 2 0 0 2 2 2 2 HEAT repeat RTP1_C1 PF10363.9 ETO24759.1 - 0.068 13.3 0.4 0.25 11.6 0.1 2.1 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF5320 PF17253.2 ETO24759.1 - 0.19 12.8 6.8 2.3 9.4 6.8 2.5 1 1 0 1 1 1 0 Family of unknown function (DUF5320) SNARE_assoc PF09335.11 ETO24760.1 - 0.00035 21.0 0.9 0.00035 21.0 0.9 1.9 2 1 1 3 3 3 1 SNARE associated Golgi protein COPI_assoc PF08507.10 ETO24760.1 - 0.028 14.5 1.1 0.15 12.1 1.1 2.0 1 1 0 1 1 1 0 COPI associated protein CAP_N PF01213.19 ETO24761.1 - 1.5e-08 34.5 0.1 1.3e-07 31.5 0.0 1.9 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal NPA PF16469.5 ETO24761.1 - 0.028 15.0 4.0 0.11 13.1 2.8 2.3 1 1 1 2 2 2 0 Nematode polyprotein allergen ABA-1 NACHT PF05729.12 ETO24762.1 - 9.7e-09 35.3 0.0 2.2e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO24762.1 - 0.00018 22.1 0.2 0.00088 19.8 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO24762.1 - 0.0031 17.8 0.0 0.013 15.7 0.0 2.1 1 1 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO24762.1 - 0.023 15.1 0.1 0.23 11.9 0.1 2.9 1 1 0 1 1 1 0 RNA helicase ABC_tran PF00005.27 ETO24762.1 - 0.052 14.1 0.1 0.31 11.6 0.0 2.4 2 0 0 2 2 2 0 ABC transporter CbiA PF01656.23 ETO24762.1 - 0.065 13.3 0.1 14 5.7 0.0 3.3 3 0 0 3 3 3 0 CobQ/CobB/MinD/ParA nucleotide binding domain RsgA_GTPase PF03193.16 ETO24762.1 - 0.091 12.7 0.1 0.83 9.5 0.0 2.6 2 0 0 2 2 2 0 RsgA GTPase WD40 PF00400.32 ETO24763.1 - 1.6e-145 468.6 50.0 9.4e-12 45.3 0.1 16.1 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24763.1 - 4.8e-39 132.5 15.7 0.001 19.3 0.0 13.7 2 2 13 15 15 15 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24763.1 - 3.8e-31 108.3 1.4 0.057 12.4 0.0 12.8 2 2 8 12 12 12 10 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO24763.1 - 2.5e-19 69.7 3.2 0.00069 19.0 0.7 7.5 3 1 5 9 9 9 6 WD40-like domain Nup160 PF11715.8 ETO24763.1 - 7.7e-16 57.8 26.5 0.29 9.7 0.0 13.4 3 2 10 14 14 14 8 Nucleoporin Nup120/160 SGL PF08450.12 ETO24763.1 - 1.3e-12 47.9 2.4 0.16 11.5 0.0 6.9 2 2 4 7 7 7 3 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 ETO24763.1 - 1.1e-08 34.8 22.2 5 7.2 0.1 10.5 10 0 0 10 10 10 2 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO24763.1 - 1.3e-08 34.8 0.8 4.1 7.6 0.0 8.7 6 4 5 11 11 11 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO24763.1 - 2.2e-07 29.8 9.4 0.45 9.0 0.1 6.4 3 2 5 8 8 8 5 Cytochrome D1 heme domain BBS2_Mid PF14783.6 ETO24763.1 - 0.00019 21.4 9.7 7 6.7 0.0 8.6 11 1 1 12 12 11 1 Ciliary BBSome complex subunit 2, middle region DUF5570 PF17731.1 ETO24763.1 - 0.0013 18.8 23.0 18 5.4 0.0 10.4 2 2 8 11 11 11 0 Family of unknown function (DUF5570) DUF1258 PF06869.12 ETO24763.1 - 0.002 17.6 0.8 3.3 7.1 0.1 4.9 3 2 4 7 7 7 1 Protein of unknown function (DUF1258) HARP PF07443.13 ETO24763.1 - 0.052 13.2 6.6 7.3 6.3 0.0 6.4 9 0 0 9 9 8 0 HepA-related protein (HARP) TRAP-delta PF05404.12 ETO24763.1 - 0.06 12.9 0.4 1.3 8.5 0.0 2.9 2 1 1 3 3 3 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) Corona_NS8 PF12093.8 ETO24763.1 - 0.075 13.6 0.0 1.5e+02 3.0 0.0 4.5 4 1 1 5 5 4 0 Coronavirus NS8 protein Read-through PF16814.5 ETO24763.1 - 0.1 12.4 5.5 5.3 6.8 0.0 5.0 5 1 1 6 6 6 0 Read-through domain DUF3475 PF11961.8 ETO24763.1 - 1.1 9.4 4.9 63 3.7 0.0 5.4 7 0 0 7 7 7 0 Domain of unknown function (DUF3475) WD40 PF00400.32 ETO24764.1 - 3.5e-61 201.7 13.8 2.2e-09 37.8 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24764.1 - 1.5e-20 73.3 5.7 0.008 16.4 0.0 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24764.1 - 3.4e-12 46.0 0.7 0.19 10.6 0.0 6.4 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO24764.1 - 3.4e-10 39.8 3.3 0.0021 17.4 0.9 3.8 3 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO24764.1 - 2.4e-07 29.8 2.2 0.59 8.7 0.0 4.7 2 1 0 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO24764.1 - 0.0016 18.3 0.1 13 5.9 0.0 4.0 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO24764.1 - 0.0077 15.2 3.5 0.33 9.8 0.1 4.0 1 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain G-alpha PF00503.20 ETO24765.1 - 5.8e-54 183.6 29.5 5.8e-54 183.6 29.5 2.4 2 1 0 2 2 2 1 G-protein alpha subunit Gtr1_RagA PF04670.12 ETO24765.1 - 3.5e-07 29.8 0.9 3.5e-07 29.8 0.9 2.2 2 1 1 3 3 3 1 Gtr1/RagA G protein conserved region Arf PF00025.21 ETO24765.1 - 4e-07 29.6 2.5 5e-07 29.3 0.3 2.2 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO24765.1 - 0.011 15.2 2.8 0.013 15.0 0.0 2.3 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AftA_C PF12249.8 ETO24765.1 - 0.022 14.4 0.2 0.052 13.2 0.2 1.6 1 0 0 1 1 1 0 Arabinofuranosyltransferase A C terminal AAA_22 PF13401.6 ETO24765.1 - 0.072 13.4 0.0 0.16 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF935 PF06074.12 ETO24766.1 - 0.0048 15.7 1.5 0.0056 15.5 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF935) DUF4820 PF16091.5 ETO24766.1 - 1.3 8.3 7.9 2 7.7 7.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Presenilin PF01080.17 ETO24766.1 - 8.2 5.1 9.4 8.8 5.0 9.4 1.2 1 0 0 1 1 1 0 Presenilin GCFC PF07842.12 ETO24767.1 - 8.3e-09 35.4 3.5 0.00082 19.1 0.1 3.0 2 1 1 3 3 3 2 GC-rich sequence DNA-binding factor-like protein HypF_C PF17788.1 ETO24767.1 - 0.26 12.0 3.3 3.6 8.3 0.1 3.3 3 0 0 3 3 3 0 HypF Kae1-like domain FlaC_arch PF05377.11 ETO24767.1 - 0.51 10.8 3.8 15 6.0 1.3 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) TPR_10 PF13374.6 ETO24768.1 - 0.18 11.7 1.3 0.79 9.7 0.1 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat HSP70 PF00012.20 ETO24769.1 - 0.04 12.1 0.0 1.7 6.8 0.0 2.3 2 0 0 2 2 2 0 Hsp70 protein WD40 PF00400.32 ETO24770.1 - 5.4e-26 90.3 23.8 2.9e-05 24.7 4.0 7.0 5 1 1 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO24770.1 - 2.4e-07 29.8 1.1 0.037 12.7 0.0 4.1 2 1 2 4 4 4 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO24770.1 - 6.1e-07 30.0 2.6 6.1e-07 30.0 2.6 2.8 2 0 0 2 2 2 1 TRAF-type zinc finger Peptidase_Mx PF15887.5 ETO24770.1 - 0.073 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative zinc-binding metallo-peptidase zf-RING-like PF08746.11 ETO24770.1 - 0.39 11.1 5.3 0.43 10.9 1.4 3.1 1 1 1 2 2 2 0 RING-like domain TSC22 PF01166.18 ETO24770.1 - 0.7 10.2 7.0 0.073 13.4 1.6 2.2 2 0 0 2 2 2 0 TSC-22/dip/bun family XRN_M PF17846.1 ETO24770.1 - 2.9 6.8 13.9 0.12 11.3 6.5 2.0 2 0 0 2 2 2 0 Xrn1 helical domain PWWP PF00855.17 ETO24772.1 - 2.3e-05 24.7 5.1 0.00014 22.2 0.4 3.2 2 1 0 2 2 2 1 PWWP domain WD40 PF00400.32 ETO24774.1 - 8.8e-61 200.4 27.9 4.8e-10 39.9 0.2 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat SLC12 PF03522.15 ETO24774.1 - 8e-40 137.2 3.3 1.2e-17 64.1 0.0 4.1 2 2 1 3 3 3 3 Solute carrier family 12 ANAPC4_WD40 PF12894.7 ETO24774.1 - 1.5e-21 76.5 3.4 7.1e-06 26.2 0.0 6.8 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24774.1 - 3e-14 52.7 0.1 0.0049 15.9 0.0 7.0 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO24774.1 - 4e-11 43.2 0.2 0.0016 18.3 0.0 3.5 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO24774.1 - 9.6e-06 25.1 0.0 1.1 8.5 0.0 3.5 2 1 2 4 4 4 4 WD40-like domain AA_permease PF00324.21 ETO24774.1 - 1.3e-05 24.0 0.9 2.4e-05 23.1 0.9 1.4 1 0 0 1 1 1 1 Amino acid permease Proteasome_A_N PF10584.9 ETO24774.1 - 0.00074 19.1 5.5 26 4.6 0.0 5.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF1513 PF07433.11 ETO24774.1 - 0.0014 17.8 0.2 2.5 7.1 0.0 3.3 3 1 0 3 3 3 2 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 ETO24774.1 - 0.004 15.7 0.3 1.1 7.7 0.1 3.0 2 1 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO24774.1 - 0.012 15.6 5.6 22 5.2 0.1 5.9 7 0 0 7 7 6 0 WD40-like Beta Propeller Repeat HERV-K_env_2 PF13804.6 ETO24774.1 - 0.013 15.2 0.0 0.032 14.0 0.0 1.6 1 0 0 1 1 1 0 Retro-transcribing viruses envelope glycoprotein Frtz PF11768.8 ETO24774.1 - 0.06 11.6 0.0 1 7.6 0.0 2.6 2 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF5046 PF16465.5 ETO24774.1 - 0.097 12.1 0.0 1.3 8.4 0.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) AA_permease PF00324.21 ETO24775.1 - 1.4e-24 86.6 8.9 2.3e-24 85.8 8.9 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETO24775.1 - 3.3e-12 46.0 8.8 3.8e-12 45.8 8.8 1.1 1 0 0 1 1 1 1 Amino acid permease IL17R_D_N PF16742.5 ETO24777.1 - 0.044 13.8 0.0 0.055 13.5 0.0 1.2 1 0 0 1 1 1 0 N-terminus of interleukin 17 receptor D PPR_2 PF13041.6 ETO24780.1 - 0.09 13.0 1.8 1.7 8.9 0.1 3.2 3 1 0 3 3 3 0 PPR repeat family PPR PF01535.20 ETO24780.1 - 0.11 12.8 0.1 0.8 10.1 0.0 2.4 2 0 0 2 2 2 0 PPR repeat WD40 PF00400.32 ETO24781.1 - 1.3e-42 143.0 11.8 9.5e-12 45.3 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24781.1 - 7.4e-21 74.3 0.0 0.00029 21.1 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24781.1 - 5.4e-13 48.6 0.2 0.0011 18.0 0.0 4.8 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO24781.1 - 1.7e-08 34.6 0.0 0.0064 16.4 0.0 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO24781.1 - 1.3e-06 28.2 5.1 1.5 8.8 0.0 5.9 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO24781.1 - 1.4e-06 27.1 0.1 0.00049 18.7 0.0 1.8 1 1 1 2 2 2 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO24781.1 - 1.7e-05 24.4 0.2 0.002 17.5 0.0 2.7 3 0 0 3 3 3 1 WD40-like domain DUF5570 PF17731.1 ETO24781.1 - 0.00012 22.2 1.6 6.7 6.8 0.0 4.1 2 1 2 4 4 4 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO24781.1 - 0.0028 17.0 0.1 0.9 8.8 0.0 3.1 2 1 0 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO24781.1 - 0.013 14.6 0.0 0.35 9.9 0.0 2.1 1 1 1 2 2 2 0 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO24781.1 - 0.028 13.2 0.2 1.1 7.9 0.2 2.7 2 1 0 2 2 2 0 Nup133 N terminal like DUF5122 PF17164.4 ETO24781.1 - 0.061 13.6 0.1 17 5.8 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller DHFR_2 PF06442.11 ETO24781.1 - 0.13 12.1 0.0 4.4 7.2 0.0 2.7 3 0 0 3 3 3 0 R67 dihydrofolate reductase Frtz PF11768.8 ETO24781.1 - 0.24 9.7 0.0 15 3.8 0.0 2.6 1 1 2 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz zf-LYAR PF08790.11 ETO24781.1 - 1.4 8.9 4.1 7.7 6.5 0.1 3.0 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger Proteasome_A_N PF10584.9 ETO24781.1 - 4.5 7.1 13.8 11 5.7 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature SURF1 PF02104.15 ETO24782.1 - 0.018 15.3 0.0 0.024 14.9 0.0 1.2 1 0 0 1 1 1 0 SURF1 family WD40 PF00400.32 ETO24783.1 - 3.6e-29 100.4 7.4 1.7e-08 35.0 0.1 6.9 7 1 0 7 7 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24783.1 - 3.6e-13 49.6 1.5 0.031 14.6 0.0 5.6 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24783.1 - 5.8e-07 28.8 0.1 1.3 7.9 0.0 4.7 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_4 PF13418.6 ETO24783.1 - 7.2e-05 22.7 0.1 0.00051 20.0 0.1 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24783.1 - 0.0043 16.6 3.7 0.019 14.5 0.3 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO24783.1 - 0.01 16.1 0.0 0.036 14.4 0.0 2.0 1 0 0 1 1 1 0 Galactose oxidase, central domain ABC2_membrane_5 PF13346.6 ETO24783.1 - 0.035 13.7 0.1 0.035 13.7 0.1 1.6 2 0 0 2 2 2 0 ABC-2 family transporter protein Nucleoporin_N PF08801.11 ETO24783.1 - 0.042 12.6 4.9 0.066 11.9 1.6 2.6 1 1 2 3 3 3 0 Nup133 N terminal like Kelch_5 PF13854.6 ETO24783.1 - 0.047 13.7 0.9 13 5.9 0.3 4.0 4 0 0 4 4 4 0 Kelch motif Kelch_6 PF13964.6 ETO24783.1 - 0.053 13.8 2.1 19 5.7 0.1 4.1 4 0 0 4 4 4 0 Kelch motif Cytochrom_D1 PF02239.16 ETO24783.1 - 0.077 11.5 0.2 0.53 8.7 0.1 2.1 2 0 0 2 2 2 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO24783.1 - 0.14 12.1 0.5 56 3.8 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Kelch_2 PF07646.15 ETO24783.1 - 0.19 11.8 0.2 0.19 11.8 0.2 4.2 4 1 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO24784.1 - 2.2e-42 142.2 7.9 1.3e-08 35.3 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24784.1 - 1e-20 73.8 0.5 0.0022 18.3 0.0 6.1 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24784.1 - 1.8e-13 50.2 0.2 0.0019 17.2 0.0 5.0 2 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO24784.1 - 4.1e-10 39.9 0.2 0.024 14.5 0.0 3.8 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO24784.1 - 7.7e-06 24.8 4.2 1.4 7.5 0.1 4.9 1 1 5 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO24784.1 - 6.6e-05 22.7 3.5 8 6.5 0.0 4.5 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO24784.1 - 0.00016 21.1 3.0 0.17 11.1 0.4 2.6 2 1 1 3 3 3 2 WD40-like domain Proteasome_A_N PF10584.9 ETO24784.1 - 2.5 7.9 8.2 34 4.2 0.0 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Cation_ATPase PF13246.6 ETO24785.1 - 1.3e-10 41.2 0.4 4.1e-10 39.6 0.1 2.0 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO24785.1 - 5.9e-08 33.3 0.0 0.00024 21.4 0.0 3.3 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase DUF4847 PF16139.5 ETO24785.1 - 0.0027 17.6 0.9 0.0065 16.4 0.9 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4847) E1-E2_ATPase PF00122.20 ETO24785.1 - 0.075 12.5 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 E1-E2 ATPase FtsX PF02687.21 ETO24785.1 - 0.12 12.9 2.5 0.25 11.8 2.5 1.4 1 0 0 1 1 1 0 FtsX-like permease family Opacity PF02462.15 ETO24785.1 - 0.15 12.1 0.0 0.47 10.6 0.0 1.7 2 0 0 2 2 2 0 Opacity family porin protein Hydrolase_3 PF08282.12 ETO24785.1 - 0.36 10.5 5.2 0.053 13.3 0.6 1.9 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase TPR_2 PF07719.17 ETO24787.1 - 7.2e-13 47.6 9.8 0.04 14.0 0.0 6.3 6 1 1 7 7 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24787.1 - 1.6e-10 40.6 4.1 0.058 13.8 0.1 5.7 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24787.1 - 3.9e-08 32.8 6.6 0.11 12.4 0.0 6.3 6 1 1 7 7 7 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24787.1 - 5.5e-07 29.8 2.4 0.0001 22.5 0.1 4.1 3 3 1 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24787.1 - 1.8e-06 28.3 1.4 3.5 8.7 0.0 5.4 4 2 1 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24787.1 - 8.3e-06 25.4 0.1 0.13 12.0 0.0 3.7 4 0 0 4 4 3 2 TPR repeat TPR_19 PF14559.6 ETO24787.1 - 1.2e-05 25.7 0.3 0.83 10.2 0.0 3.9 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO24787.1 - 8.8e-05 23.1 1.7 0.52 11.0 0.0 4.5 3 2 2 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24787.1 - 0.00011 22.6 0.3 8.9 7.2 0.0 5.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24787.1 - 0.00025 21.0 0.8 7 7.1 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO24787.1 - 0.0043 17.2 0.4 5 7.3 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO24787.1 - 0.031 14.5 16.3 0.21 11.8 0.6 4.7 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ETO24787.1 - 0.033 14.2 0.4 54 4.2 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat SCAI PF12070.8 ETO24787.1 - 0.045 12.6 2.8 1.5 7.6 0.2 2.1 2 0 0 2 2 2 0 Protein SCAI CDC45 PF02724.14 ETO24787.1 - 0.7 8.1 4.2 1.2 7.4 4.2 1.3 1 0 0 1 1 1 0 CDC45-like protein FAM176 PF14851.6 ETO24787.1 - 1.3 8.7 5.0 2.9 7.5 5.0 1.5 1 0 0 1 1 1 0 FAM176 family zf-C2H2_3rep PF18868.1 ETO24787.1 - 1.7 9.3 6.0 32 5.2 0.2 3.1 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats NOA36 PF06524.12 ETO24787.1 - 3 7.1 18.7 7.9 5.7 18.7 1.7 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO24787.1 - 3.4 5.8 7.4 4.5 5.4 7.4 1.1 1 0 0 1 1 1 0 Nop14-like family PBP1_TM PF14812.6 ETO24787.1 - 3.7 8.0 10.0 11 6.5 10.0 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 ETO24787.1 - 4.3 7.8 16.4 19 5.7 16.8 1.8 2 0 0 2 2 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ETO24787.1 - 5.5 6.0 17.4 8.6 5.4 17.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO24787.1 - 5.6 4.9 10.9 8 4.4 10.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi Pox_Ag35 PF03286.14 ETO24787.1 - 7 6.4 10.5 12 5.6 10.5 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein TPR_8 PF13181.6 ETO24788.1 - 6e-10 38.5 10.6 0.0042 17.2 2.2 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24788.1 - 4.8e-09 35.6 12.2 0.009 15.8 0.1 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24788.1 - 1.4e-08 34.2 10.6 0.018 15.1 0.1 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24788.1 - 3e-06 27.4 6.6 0.008 16.4 0.1 3.1 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24788.1 - 1e-05 25.9 0.9 0.12 13.3 0.0 2.8 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO24788.1 - 0.00012 22.5 0.4 0.04 14.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24788.1 - 0.00055 19.8 4.1 2.2 8.5 2.0 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24788.1 - 0.0028 17.9 2.7 0.67 10.5 0.1 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24788.1 - 0.0044 16.7 5.6 0.012 15.3 0.0 3.1 4 0 0 4 4 4 1 TPR repeat TPR_16 PF13432.6 ETO24788.1 - 0.0067 17.1 0.1 0.72 10.5 0.0 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24788.1 - 0.045 13.6 6.0 18 5.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24788.1 - 0.18 12.5 5.3 5.4 7.9 1.3 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO24788.1 - 0.55 9.7 3.1 3.2 7.3 0.5 2.9 3 0 0 3 3 3 0 SHNi-TPR TPR_3 PF07720.12 ETO24788.1 - 1 9.4 7.4 0.59 10.2 4.4 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat Claudin_3 PF06653.11 ETO24789.1 - 0.011 15.7 1.4 0.018 15.0 1.4 1.4 1 0 0 1 1 1 0 Tight junction protein, Claudin-like Ashwin PF15323.6 ETO24789.1 - 0.073 13.1 14.9 0.14 12.2 14.8 1.5 1 1 0 1 1 1 0 Developmental protein Secretin_N_2 PF07655.13 ETO24789.1 - 2.6 8.7 30.5 2.1 8.9 19.6 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain Prominin PF05478.11 ETO24791.1 - 0.0022 16.1 7.0 0.026 12.5 0.0 3.0 3 0 0 3 3 3 3 Prominin SAP PF02037.27 ETO24792.1 - 5.3e-08 32.4 0.3 9.9e-08 31.6 0.3 1.5 1 0 0 1 1 1 1 SAP domain EbsA PF17255.2 ETO24792.1 - 1.9 8.8 6.6 4.1 7.8 6.6 1.5 1 0 0 1 1 1 0 EbsA-like protein PPPI_inhib PF14895.6 ETO24795.1 - 0.028 13.6 0.7 0.033 13.4 0.7 1.1 1 0 0 1 1 1 0 Protein phosphatase 1 inhibitor Pex26 PF07163.12 ETO24795.1 - 0.031 13.6 0.1 0.042 13.1 0.1 1.1 1 0 0 1 1 1 0 Pex26 protein DUF3915 PF13054.6 ETO24796.1 - 0.028 14.4 3.1 0.11 12.5 3.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Tom22 PF04281.13 ETO24796.1 - 0.029 14.2 0.4 0.029 14.2 0.4 2.6 3 0 0 3 3 3 0 Mitochondrial import receptor subunit Tom22 B2-adapt-app_C PF09066.10 ETO24797.1 - 1.8e-20 73.1 0.1 4.3e-20 71.9 0.1 1.7 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Pox_Ag35 PF03286.14 ETO24797.1 - 0.0068 16.2 0.5 0.016 15.0 0.5 1.5 1 0 0 1 1 1 1 Pox virus Ag35 surface protein AP4E_app_platf PF14807.6 ETO24797.1 - 0.046 14.1 0.4 0.1 13.0 0.4 1.6 1 0 0 1 1 1 0 Adaptin AP4 complex epsilon appendage platform Secretin_N_2 PF07655.13 ETO24797.1 - 7.9 7.1 22.4 0.89 10.1 16.5 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain PAP_central PF04928.17 ETO24798.1 - 7.3e-08 31.7 0.1 1.5e-07 30.7 0.0 1.5 2 0 0 2 2 2 1 Poly(A) polymerase central domain PAP_RNA-bind PF04926.15 ETO24798.1 - 0.0084 15.8 0.0 0.068 12.8 0.1 2.0 2 0 0 2 2 2 1 Poly(A) polymerase predicted RNA binding domain Med3 PF11593.8 ETO24799.1 - 0.00089 18.6 10.2 0.00098 18.4 10.2 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal Adeno_PV PF03910.13 ETO24799.1 - 0.0059 15.4 0.2 0.0068 15.2 0.2 1.1 1 0 0 1 1 1 1 Adenovirus minor core protein PV DUF4484 PF14831.6 ETO24799.1 - 0.0072 16.4 4.2 0.0093 16.0 4.2 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4484) Neur_chan_memb PF02932.16 ETO24799.1 - 0.017 15.2 5.3 0.019 15.0 5.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FTZ PF03867.14 ETO24799.1 - 0.023 14.3 6.1 0.03 13.9 6.1 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region TFIIA PF03153.13 ETO24799.1 - 0.093 12.7 15.6 0.11 12.5 15.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Spt20 PF12090.8 ETO24799.1 - 0.14 11.7 16.6 0.19 11.3 16.6 1.3 1 0 0 1 1 1 0 Spt20 family Roughex PF06020.11 ETO24799.1 - 0.48 9.5 6.4 0.57 9.2 6.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein SUIM_assoc PF16619.5 ETO24799.1 - 0.49 10.5 20.0 1.8 8.7 20.0 2.0 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Vfa1 PF08432.10 ETO24799.1 - 0.59 10.4 12.0 0.76 10.1 12.0 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Hydin_ADK PF17213.3 ETO24799.1 - 0.68 10.2 8.6 0.86 9.9 8.6 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 ETO24799.1 - 0.72 8.6 8.2 0.76 8.5 8.2 1.1 1 0 0 1 1 1 0 Presenilin Kei1 PF08552.11 ETO24799.1 - 0.83 9.5 3.7 1.1 9.1 3.7 1.3 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Zip PF02535.22 ETO24799.1 - 1.1 8.4 3.7 1.2 8.3 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Med19 PF10278.9 ETO24799.1 - 3.6 7.5 8.9 0.27 11.1 2.9 1.9 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 baeRF_family10 PF18854.1 ETO24799.1 - 4.6 7.5 8.4 5.8 7.2 6.0 1.9 1 1 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 10 Ig_mannosidase PF17753.1 ETO24800.1 - 2.3e-19 68.9 1.0 3.1e-19 68.5 1.0 1.2 1 0 0 1 1 1 1 Ig-fold domain Exo_endo_phos PF03372.23 ETO24803.1 - 1.1e-09 38.2 0.1 3.4e-05 23.5 0.0 2.3 2 1 0 2 2 2 2 Endonuclease/Exonuclease/phosphatase family ETRAMP PF09716.10 ETO24803.1 - 0.0073 16.3 5.3 0.017 15.1 0.7 3.1 3 0 0 3 3 3 1 Malarial early transcribed membrane protein (ETRAMP) POT1PC PF16686.5 ETO24803.1 - 0.061 13.2 0.5 0.18 11.7 0.5 1.8 1 1 0 1 1 1 0 ssDNA-binding domain of telomere protection protein WBP-1 PF11669.8 ETO24803.1 - 0.17 12.5 1.1 14 6.3 0.0 2.6 2 0 0 2 2 2 0 WW domain-binding protein 1 Ac76 PF05814.11 ETO24803.1 - 5.9 7.0 9.5 0.53 10.3 0.2 3.3 4 1 0 4 4 4 0 Orf76 (Ac76) NT-C2 PF10358.9 ETO24804.1 - 4.4e-09 36.2 1.4 6.3e-09 35.7 0.8 1.5 2 0 0 2 2 2 1 N-terminal C2 in EEIG1 and EHBP1 proteins APG6_N PF17675.1 ETO24805.1 - 0.0044 17.5 17.9 0.0085 16.6 8.0 2.1 1 1 1 2 2 2 1 Apg6 coiled-coil region Jnk-SapK_ap_N PF09744.9 ETO24805.1 - 0.005 17.1 13.4 0.08 13.2 7.4 2.1 2 0 0 2 2 2 2 JNK_SAPK-associated protein-1 DUF4407 PF14362.6 ETO24805.1 - 0.011 15.1 1.7 0.015 14.6 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Swi5 PF07061.11 ETO24805.1 - 0.016 15.3 2.4 0.016 15.3 2.4 2.4 2 0 0 2 2 2 0 Swi5 Mitovir_RNA_pol PF05919.11 ETO24805.1 - 0.019 14.2 7.4 0.023 13.9 7.4 1.0 1 0 0 1 1 1 0 Mitovirus RNA-dependent RNA polymerase RILP PF11461.8 ETO24805.1 - 0.021 15.0 4.9 0.021 15.0 4.9 2.1 2 0 0 2 2 2 0 Rab interacting lysosomal protein DUF4199 PF13858.6 ETO24805.1 - 0.022 15.1 2.6 0.87 10.0 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) TPR_MLP1_2 PF07926.12 ETO24805.1 - 0.023 14.7 13.8 0.17 11.9 6.4 2.3 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4515 PF14988.6 ETO24805.1 - 0.026 14.4 15.7 0.066 13.0 5.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4515) DUF948 PF06103.11 ETO24805.1 - 0.032 14.5 0.8 0.032 14.5 0.8 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1073 PF06381.11 ETO24805.1 - 0.033 13.0 1.4 0.039 12.7 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1073) ADIP PF11559.8 ETO24805.1 - 0.047 13.8 20.2 0.53 10.4 7.8 2.1 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Tup_N PF08581.10 ETO24805.1 - 0.069 13.5 14.1 0.5 10.7 7.4 2.5 2 1 0 2 2 2 0 Tup N-terminal ATG16 PF08614.11 ETO24805.1 - 0.12 12.6 16.0 1.1 9.4 6.2 2.3 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) LMBR1 PF04791.16 ETO24805.1 - 0.15 10.9 6.5 0.2 10.6 6.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF3584 PF12128.8 ETO24805.1 - 0.16 9.5 10.5 0.21 9.1 10.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF1319 PF07028.11 ETO24805.1 - 0.18 12.0 8.0 0.63 10.3 0.7 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) Golgin_A5 PF09787.9 ETO24805.1 - 0.22 11.0 15.0 0.058 12.9 6.5 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 KELK PF15796.5 ETO24805.1 - 0.23 12.0 18.1 0.38 11.2 7.8 2.3 2 0 0 2 2 2 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Csm1_N PF18504.1 ETO24805.1 - 0.24 11.7 15.5 0.49 10.8 2.5 2.9 2 1 1 3 3 3 0 Csm1 N-terminal domain DUF4482 PF14818.6 ETO24805.1 - 0.5 11.2 12.2 0.47 11.3 4.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4482) DUF3450 PF11932.8 ETO24805.1 - 0.58 9.4 13.5 0.48 9.7 6.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) End3 PF12761.7 ETO24805.1 - 0.76 9.9 13.4 1.9 8.6 6.7 2.1 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 DUF5320 PF17253.2 ETO24805.1 - 0.95 10.6 5.8 2 9.5 0.8 2.4 1 1 0 2 2 2 0 Family of unknown function (DUF5320) DUF148 PF02520.17 ETO24805.1 - 1 9.5 15.7 0.075 13.1 8.2 2.1 1 1 0 2 2 2 0 Domain of unknown function DUF148 NAD_binding_7 PF13241.6 ETO24805.1 - 1.2 9.6 4.2 0.62 10.5 1.5 1.7 1 1 1 2 2 2 0 Putative NAD(P)-binding HALZ PF02183.18 ETO24805.1 - 1.3 9.3 11.3 3.7 7.8 1.4 3.3 2 2 1 3 3 3 0 Homeobox associated leucine zipper Tropomyosin_1 PF12718.7 ETO24805.1 - 1.4 9.1 18.3 1 9.5 2.4 2.1 2 0 0 2 2 2 0 Tropomyosin like Sec2p PF06428.11 ETO24805.1 - 1.6 8.7 16.4 3.6 7.6 7.9 2.3 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p FPP PF05911.11 ETO24805.1 - 1.6 6.8 18.9 2.4 6.2 18.9 1.2 1 1 0 1 1 1 0 Filament-like plant protein, long coiled-coil THOC7 PF05615.13 ETO24805.1 - 1.8 8.8 12.0 0.86 9.9 6.4 2.6 2 1 0 2 2 2 0 Tho complex subunit 7 DUF641 PF04859.12 ETO24805.1 - 1.9 8.8 10.0 0.83 10.0 6.7 1.9 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) FlaC_arch PF05377.11 ETO24805.1 - 2.4 8.6 12.7 2.5 8.5 2.7 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) CALCOCO1 PF07888.11 ETO24805.1 - 2.5 6.9 14.7 1.6 7.5 5.7 2.0 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like Cnn_1N PF07989.11 ETO24805.1 - 6.9 6.9 16.9 8.4 6.6 1.4 2.7 2 1 0 2 2 2 0 Centrosomin N-terminal motif 1 PRP1_N PF06424.12 ETO24805.1 - 9.7 6.6 8.3 61 4.0 8.3 2.3 1 1 0 1 1 1 0 PRP1 splicing factor, N-terminal DUF1771 PF08590.10 ETO24806.1 - 0.013 15.8 0.1 0.048 14.1 0.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF1771) Sec7 PF01369.20 ETO24807.1 - 4.5e-40 137.3 0.5 4.5e-40 137.3 0.5 1.6 2 0 0 2 2 2 1 Sec7 domain SWIRM PF04433.17 ETO24807.1 - 0.062 13.7 0.3 0.41 11.0 0.1 2.3 2 0 0 2 2 2 0 SWIRM domain LXG PF04740.12 ETO24807.1 - 0.091 12.5 2.9 0.18 11.5 0.3 2.2 2 0 0 2 2 2 0 LXG domain of WXG superfamily DUF3782 PF12644.7 ETO24807.1 - 0.11 12.7 0.1 0.4 10.9 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3782) Actin PF00022.19 ETO24808.1 - 2.4e-135 451.3 0.0 8e-135 449.6 0.0 1.7 1 1 0 1 1 1 1 Actin TPR_12 PF13424.6 ETO24809.1 - 3.1e-38 129.9 0.6 2.2e-21 75.9 0.1 3.5 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24809.1 - 1.3e-30 104.4 0.0 3.7e-08 33.0 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24809.1 - 2.9e-29 99.7 13.9 3e-09 36.3 2.4 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24809.1 - 1.4e-25 87.4 0.4 1.9e-06 27.5 0.1 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24809.1 - 4.5e-25 85.7 13.6 2.9e-09 36.4 2.0 5.1 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24809.1 - 1.2e-23 81.3 12.1 5.8e-08 32.3 1.2 6.0 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24809.1 - 9.8e-14 50.8 6.5 0.0033 17.1 0.2 6.4 5 2 2 7 7 7 4 TPR repeat SNAP PF14938.6 ETO24809.1 - 6.8e-12 45.4 0.9 7.4e-06 25.6 0.0 3.2 2 1 2 4 4 4 3 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO24809.1 - 8.3e-09 35.2 1.3 0.018 15.4 0.0 4.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO24809.1 - 2.4e-08 34.1 6.1 0.0012 19.3 0.4 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat PPR PF01535.20 ETO24809.1 - 4.7e-06 26.5 1.3 0.52 10.7 0.1 3.9 3 0 0 3 3 3 2 PPR repeat TPR_14 PF13428.6 ETO24809.1 - 7.8e-06 26.3 0.0 0.17 12.8 0.0 4.3 5 0 0 5 5 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO24809.1 - 1e-05 26.1 0.0 0.00039 21.0 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO24809.1 - 2.3e-05 24.5 1.6 7.2e-05 22.9 1.6 1.8 1 1 0 1 1 1 1 Caspase domain TPR_19 PF14559.6 ETO24809.1 - 0.00022 21.7 0.0 2 9.0 0.0 3.6 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO24809.1 - 0.00078 19.2 3.2 0.001 18.9 0.7 2.5 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) SPO22 PF08631.10 ETO24809.1 - 0.0059 16.1 2.6 0.0077 15.8 0.2 2.4 3 0 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like DUF5113 PF17140.4 ETO24809.1 - 0.03 14.1 3.7 2.7 7.8 0.0 3.8 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) Secapin PF17521.2 ETO24809.1 - 0.083 12.7 0.0 0.16 11.8 0.0 1.4 1 0 0 1 1 1 0 Honey bee peptides RPN7 PF10602.9 ETO24809.1 - 0.12 12.1 7.9 3.8 7.2 0.1 3.8 3 1 1 4 4 4 0 26S proteasome subunit RPN7 MIT PF04212.18 ETO24809.1 - 0.75 9.9 3.2 13 5.9 0.3 3.7 3 1 0 3 3 3 0 MIT (microtubule interacting and transport) domain HSP70 PF00012.20 ETO24810.1 - 1.2e-38 132.7 7.7 2.9e-38 131.4 7.7 1.5 1 1 0 1 1 1 1 Hsp70 protein PARP PF00644.20 ETO24810.1 - 2.5e-08 33.7 0.0 7.1e-08 32.3 0.0 1.7 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain DUF4500 PF14937.6 ETO24810.1 - 0.065 13.2 0.3 2.4 8.2 0.1 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4500) DUF2254 PF10011.9 ETO24811.1 - 0.007 15.2 0.4 0.0095 14.8 0.4 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2254) DUF2270 PF10028.9 ETO24811.1 - 0.029 14.0 0.6 0.062 12.9 0.6 1.5 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) DUF2615 PF11027.8 ETO24811.1 - 0.069 13.3 0.1 0.15 12.2 0.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) WW PF00397.26 ETO24812.1 - 0.00057 19.9 0.0 0.0011 19.0 0.0 1.5 1 0 0 1 1 1 1 WW domain Raftlin PF15250.6 ETO24812.1 - 0.22 10.2 10.3 0.27 9.9 10.3 1.1 1 0 0 1 1 1 0 Raftlin SAPS PF04499.15 ETO24812.1 - 3.4 6.4 18.3 4.3 6.0 18.3 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein SID-1_RNA_chan PF13965.6 ETO24812.1 - 3.8 5.8 5.2 4.4 5.6 5.2 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Smg8_Smg9 PF10220.9 ETO24812.1 - 6.2 5.0 12.7 7.8 4.7 12.7 1.0 1 0 0 1 1 1 0 Smg8_Smg9 Sulfotransfer_2 PF03567.14 ETO24813.1 - 1.7e-10 41.3 0.3 2.3e-10 40.8 0.3 1.3 1 1 0 1 1 1 1 Sulfotransferase family CAP_GLY PF01302.25 ETO24814.1 - 0.00011 22.2 0.4 0.00019 21.4 0.4 1.4 1 0 0 1 1 1 1 CAP-Gly domain PNKP-ligase_C PF16536.5 ETO24814.1 - 0.19 12.0 0.0 0.32 11.3 0.0 1.3 1 0 0 1 1 1 0 PNKP adenylyltransferase domain, C-terminal region zf-C3H2C3 PF17122.5 ETO24814.1 - 3.1 7.9 4.5 18 5.4 0.3 2.5 3 0 0 3 3 3 0 Zinc-finger LAP1C PF05609.12 ETO24815.1 - 0.11 11.6 25.2 0.14 11.2 25.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RIFIN PF02009.16 ETO24815.1 - 0.13 12.1 10.1 0.17 11.7 10.1 1.4 1 0 0 1 1 1 0 Rifin PAT1 PF09770.9 ETO24815.1 - 0.17 10.1 39.5 0.25 9.6 39.5 1.2 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SprA-related PF12118.8 ETO24815.1 - 0.37 9.9 43.8 0.012 14.8 36.5 1.9 2 0 0 2 2 2 0 SprA-related family CCSAP PF15748.5 ETO24815.1 - 0.58 10.3 29.7 0.99 9.5 29.7 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated GREB1 PF15782.5 ETO24815.1 - 0.66 7.0 34.7 0.82 6.7 34.7 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer eIF-3_zeta PF05091.12 ETO24815.1 - 1.1 8.2 22.9 1.4 7.8 22.9 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 ETO24815.1 - 1.2 8.9 19.2 1.8 8.3 19.2 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 XRN_M PF17846.1 ETO24815.1 - 1.8 7.4 11.4 2.6 6.9 11.4 1.4 1 0 0 1 1 1 0 Xrn1 helical domain DUF572 PF04502.13 ETO24815.1 - 2 7.9 25.8 3.4 7.2 25.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) NARP1 PF12569.8 ETO24815.1 - 2.1 7.1 12.5 2.9 6.7 12.5 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 MCU PF04678.13 ETO24815.1 - 2.6 8.1 8.9 4.7 7.3 8.9 1.6 1 0 0 1 1 1 0 Mitochondrial calcium uniporter SMYLE_N PF18615.1 ETO24815.1 - 4.5 6.7 22.2 6.4 6.2 22.2 1.3 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain ECH_2 PF16113.5 ETO24816.1 - 1.4e-109 366.7 0.0 1.7e-109 366.4 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ETO24816.1 - 7.4e-28 97.5 0.0 1e-25 90.5 0.0 2.3 1 1 1 2 2 2 2 Enoyl-CoA hydratase/isomerase SID-1_RNA_chan PF13965.6 ETO24817.1 - 0.022 13.2 0.0 0.033 12.6 0.0 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PA26 PF04636.13 ETO24817.1 - 0.055 12.4 0.3 0.075 11.9 0.3 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) BUD22 PF09073.10 ETO24817.1 - 0.12 11.7 30.2 0.18 11.1 30.2 1.2 1 0 0 1 1 1 0 BUD22 DUF2151 PF10221.9 ETO24817.1 - 0.99 7.9 11.4 1.3 7.5 11.4 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Connexin PF00029.19 ETO24817.1 - 1.1 8.9 7.6 2.4 7.9 7.6 1.6 1 0 0 1 1 1 0 Connexin DUF2457 PF10446.9 ETO24817.1 - 1.2 8.2 49.3 0.067 12.3 31.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) NARP1 PF12569.8 ETO24817.1 - 1.2 7.9 13.6 2.3 7.0 13.6 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 SAPS PF04499.15 ETO24817.1 - 1.5 7.5 13.3 2.3 6.9 13.3 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Presenilin PF01080.17 ETO24817.1 - 1.7 7.3 9.9 2.7 6.7 9.9 1.3 1 0 0 1 1 1 0 Presenilin DUF2722 PF10846.8 ETO24817.1 - 2 7.2 22.2 0.068 12.1 11.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) DUF3245 PF11595.8 ETO24817.1 - 2.8 8.4 22.1 0.67 10.4 9.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3245) LAP1C PF05609.12 ETO24817.1 - 3.6 6.6 15.8 5.2 6.1 15.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) O-antigen_lig PF13425.6 ETO24817.1 - 3.9 6.2 5.7 6.7 5.4 5.7 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sigma70_ner PF04546.13 ETO24817.1 - 3.9 7.3 29.0 1.4 8.8 17.6 2.4 2 0 0 2 2 2 0 Sigma-70, non-essential region Peptidase_S64 PF08192.11 ETO24817.1 - 4.7 5.6 6.4 6.3 5.2 6.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 FYDLN_acid PF09538.10 ETO24817.1 - 5.3 7.8 36.9 0.55 10.9 21.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 ETO24817.1 - 6.9 7.1 10.7 0.69 10.3 5.4 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 DUF2052 PF09747.9 ETO24817.1 - 7.9 6.6 37.3 9.3e+02 -0.2 37.3 2.1 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) AAA_11 PF13086.6 ETO24817.1 - 8.6 6.1 9.6 14 5.3 9.6 1.3 1 0 0 1 1 1 0 AAA domain SAGA-Tad1 PF12767.7 ETO24820.1 - 0.00039 20.2 3.5 0.00039 20.2 3.5 2.5 2 1 0 2 2 2 1 Transcriptional regulator of RNA polII, SAGA, subunit VirD1 PF07328.11 ETO24820.1 - 0.074 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 T-DNA border endonuclease VirD1 Mif2_N PF15624.6 ETO24821.1 - 0.021 15.6 0.9 0.033 14.9 0.9 1.2 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal Spem1 PF15670.5 ETO24822.1 - 0.01 15.5 2.5 0.013 15.1 2.5 1.1 1 0 0 1 1 1 1 Spermatid maturation protein 1 GEP5 PF17053.5 ETO24822.1 - 0.011 15.6 0.6 0.014 15.2 0.6 1.2 1 0 0 1 1 1 0 Genetic interactor of prohibitin 5 ATP-cone PF03477.16 ETO24822.1 - 0.092 13.3 3.8 0.66 10.6 3.8 2.1 1 1 0 1 1 1 0 ATP cone domain zf-C3HC4_3 PF13920.6 ETO24823.1 - 4.5e-05 23.2 16.6 0.00013 21.8 16.6 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO24823.1 - 0.0015 18.9 21.5 0.0015 18.9 21.5 2.2 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO24823.1 - 0.0021 17.9 20.9 0.0058 16.5 20.9 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO24823.1 - 0.15 12.0 16.9 0.48 10.3 16.9 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_10 PF16685.5 ETO24823.1 - 0.25 11.5 14.0 0.65 10.2 14.0 1.8 1 0 0 1 1 1 0 zinc RING finger of MSL2 PDEase_I PF00233.19 ETO24824.1 - 2.1e-67 227.3 4.6 1.6e-64 217.9 4.6 2.4 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETO24824.1 - 0.08 13.2 0.1 0.21 11.8 0.1 1.7 1 0 0 1 1 1 0 HD domain DUF3416 PF11896.8 ETO24824.1 - 0.085 13.1 0.1 0.19 12.0 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3416) Mito_carr PF00153.27 ETO24825.1 - 6.5e-07 29.2 0.1 1.1e-06 28.5 0.1 1.4 1 0 0 1 1 1 1 Mitochondrial carrier protein CM_1 PF07736.11 ETO24825.1 - 0.052 13.9 0.2 0.09 13.2 0.2 1.5 1 0 0 1 1 1 0 Chorismate mutase type I MitMem_reg PF13012.6 ETO24825.1 - 0.29 11.6 2.4 5.5 7.5 2.5 2.2 1 1 0 1 1 1 0 Maintenance of mitochondrial structure and function DUF1690 PF07956.11 ETO24825.1 - 4.3 7.8 13.2 0.32 11.4 7.5 1.8 2 0 0 2 2 2 0 Protein of Unknown function (DUF1690) Mito_carr PF00153.27 ETO24826.1 - 4.7e-22 77.7 0.2 1.7e-20 72.7 0.1 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein FlaC_arch PF05377.11 ETO24827.1 - 2.9 8.3 6.0 2.3 8.7 0.5 2.9 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) GCV_T PF01571.21 ETO24828.1 - 5.1e-07 29.3 0.0 6.3e-06 25.7 0.0 2.1 2 0 0 2 2 2 1 Aminomethyltransferase folate-binding domain Mito_carr PF00153.27 ETO24829.1 - 1.2e-47 159.7 7.8 2.5e-17 62.6 0.2 3.0 3 0 0 3 3 3 3 Mitochondrial carrier protein UPF0254 PF06787.11 ETO24829.1 - 0.082 12.7 0.1 0.15 11.8 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0254) DUF3306 PF11748.8 ETO24830.1 - 0.17 12.8 1.2 0.29 12.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) G-alpha PF00503.20 ETO24831.1 - 2.6e-28 99.2 4.4 3.3e-28 98.9 4.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit YnfE PF17452.2 ETO24831.1 - 0.064 13.6 0.1 0.13 12.6 0.1 1.5 1 0 0 1 1 1 0 Uncharacterized YnfE-like GST_C_3 PF14497.6 ETO24832.1 - 7.1e-18 64.6 0.1 1.1e-17 64.0 0.1 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO24832.1 - 9.3e-08 32.2 0.1 1.8e-07 31.2 0.1 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETO24832.1 - 0.00011 22.1 0.0 0.00026 21.0 0.0 1.7 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETO24832.1 - 0.002 18.4 0.1 0.016 15.5 0.1 2.4 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain RhoGEF PF00621.20 ETO24832.1 - 0.13 12.5 0.3 0.18 12.0 0.3 1.3 1 0 0 1 1 1 0 RhoGEF domain Mg_trans_NIPA PF05653.14 ETO24833.1 - 1.4e-08 34.2 3.2 1.8e-08 33.9 3.2 1.1 1 0 0 1 1 1 1 Magnesium transporter NIPA DUF3392 PF11872.8 ETO24833.1 - 0.039 14.2 1.6 0.064 13.5 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3392) DUF3810 PF12725.7 ETO24833.1 - 1 8.6 4.7 1.4 8.2 4.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) Guanylate_cyc PF00211.20 ETO24835.1 - 4.1e-12 46.1 0.0 7e-12 45.3 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Nop14 PF04147.12 ETO24835.1 - 0.054 11.7 22.3 0.073 11.3 22.3 1.1 1 0 0 1 1 1 0 Nop14-like family CNDH2_C PF16858.5 ETO24835.1 - 1.4 8.7 22.6 0.73 9.6 20.4 1.6 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term 7TMR-DISM_7TM PF07695.11 ETO24835.1 - 3.1 7.6 10.2 6.1 6.7 0.2 3.1 2 1 1 3 3 3 0 7TM diverse intracellular signalling RR_TM4-6 PF06459.12 ETO24835.1 - 6.9 6.4 27.6 24 4.6 27.8 1.7 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 FSA_C PF10479.9 ETO24837.1 - 0.057 11.5 5.1 0.086 11.0 5.1 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pkinase PF00069.25 ETO24838.1 - 8.6e-54 182.7 0.0 1.2e-53 182.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24838.1 - 1.6e-30 106.3 0.0 2.2e-30 105.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO24838.1 - 8e-09 35.2 0.1 2.1e-08 33.8 0.0 1.7 1 1 1 2 2 2 1 Kinase-like APH PF01636.23 ETO24838.1 - 7.2e-05 22.8 0.1 0.00015 21.8 0.0 1.4 2 0 0 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO24838.1 - 0.0082 15.5 0.0 0.0082 15.5 0.0 2.2 4 0 0 4 4 4 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO24838.1 - 0.017 13.9 0.0 0.034 12.9 0.0 1.5 2 0 0 2 2 2 0 Fungal protein kinase Seadorna_VP7 PF07387.11 ETO24838.1 - 0.018 14.1 0.0 0.28 10.2 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 WD40 PF00400.32 ETO24839.1 - 1.2e-60 200.0 13.7 5.2e-10 39.8 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24839.1 - 2e-15 56.9 0.5 0.033 14.5 0.0 5.6 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO24839.1 - 2.1e-10 40.1 0.1 0.069 12.1 0.0 5.0 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO24839.1 - 5.1e-10 38.6 1.1 0.27 9.8 0.0 5.9 2 1 4 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO24839.1 - 6.7e-05 22.8 0.1 0.0058 16.5 0.0 2.9 2 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETO24839.1 - 8.9e-05 21.4 5.2 0.15 10.7 0.1 4.2 1 1 1 3 3 3 3 Nup133 N terminal like PD40 PF07676.12 ETO24839.1 - 0.00014 21.7 1.4 3.7 7.6 0.0 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO24839.1 - 0.00016 21.8 1.0 0.85 9.7 0.1 4.1 1 1 2 4 4 4 1 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO24839.1 - 0.00022 20.7 0.6 0.052 12.9 0.2 3.6 2 1 0 2 2 2 1 WD40-like domain DUF4265 PF14085.6 ETO24839.1 - 0.0014 18.6 0.0 4.4 7.3 0.0 4.2 2 2 2 4 4 4 1 Domain of unknown function (DUF4265) Frtz PF11768.8 ETO24839.1 - 0.0044 15.4 0.0 0.012 13.9 0.0 1.6 1 1 1 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Proteasome_A_N PF10584.9 ETO24839.1 - 0.15 11.7 4.5 25 4.7 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature FH2 PF02181.23 ETO24840.1 - 2.5e-33 115.7 0.5 4.2e-33 115.0 0.5 1.3 1 0 0 1 1 1 1 Formin Homology 2 Domain CCDC53 PF10152.9 ETO24840.1 - 0.00084 19.8 0.4 0.0045 17.4 0.0 2.2 3 0 0 3 3 3 1 Subunit CCDC53 of WASH complex SAM_DrpA PF18255.1 ETO24840.1 - 0.33 11.2 3.0 2 8.7 0.1 2.4 2 0 0 2 2 2 0 DNA processing protein A sterile alpha motif domain Phage_GP20 PF06810.11 ETO24841.1 - 0.00058 19.7 2.4 0.00092 19.0 2.4 1.3 1 0 0 1 1 1 1 Phage minor structural protein GP20 CCDC53 PF10152.9 ETO24841.1 - 0.00079 19.9 4.3 0.001 19.5 4.3 1.2 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex SlyX PF04102.12 ETO24841.1 - 0.0041 17.7 1.1 0.01 16.4 1.1 1.7 1 1 0 1 1 1 1 SlyX HALZ PF02183.18 ETO24841.1 - 0.007 16.6 6.5 0.14 12.4 3.3 2.3 1 1 1 2 2 2 2 Homeobox associated leucine zipper PspA_IM30 PF04012.12 ETO24841.1 - 0.032 13.8 2.1 0.05 13.2 2.1 1.2 1 0 0 1 1 1 0 PspA/IM30 family DUF5082 PF16888.5 ETO24841.1 - 0.057 13.7 2.6 0.14 12.5 2.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DUF4349 PF14257.6 ETO24841.1 - 0.12 11.8 0.2 0.19 11.1 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Fib_alpha PF08702.10 ETO24841.1 - 0.2 11.9 3.4 0.12 12.6 1.1 1.6 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family LPP PF04728.13 ETO24841.1 - 0.21 12.0 4.5 0.12 12.8 1.3 2.0 1 1 1 2 2 2 0 Lipoprotein leucine-zipper DivIC PF04977.15 ETO24841.1 - 0.33 10.8 3.3 0.89 9.4 3.3 1.8 1 1 0 1 1 1 0 Septum formation initiator ADIP PF11559.8 ETO24841.1 - 0.36 10.9 5.8 0.056 13.5 1.7 1.6 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding XhlA PF10779.9 ETO24841.1 - 0.42 10.8 2.4 0.88 9.8 2.4 1.6 1 0 0 1 1 1 0 Haemolysin XhlA DHR10 PF18595.1 ETO24841.1 - 0.82 9.7 6.4 0.058 13.5 1.5 1.6 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Lectin_N PF03954.14 ETO24841.1 - 1.4 8.7 4.2 0.37 10.5 1.2 1.5 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain TMF_DNA_bd PF12329.8 ETO24841.1 - 7.1 6.7 12.5 0.1 12.6 3.9 2.0 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BTG PF07742.12 ETO24842.1 - 0.19 11.6 5.8 0.1 12.4 0.3 3.3 2 1 0 2 2 2 0 BTG family PhoU PF01895.19 ETO24842.1 - 6.5 7.3 13.0 3.9 8.0 0.4 4.7 3 1 1 4 4 4 0 PhoU domain UPF0122 PF04297.14 ETO24843.1 - 0.011 15.9 1.1 0.029 14.6 0.1 2.2 2 0 0 2 2 2 0 Putative helix-turn-helix protein, YlxM / p13 like COX2_TM PF02790.15 ETO24843.1 - 0.024 14.8 0.4 4.9 7.4 0.0 2.7 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain PDR_CDR PF06422.12 ETO24843.1 - 0.36 10.8 2.7 0.62 10.0 1.5 2.2 2 0 0 2 2 2 0 CDR ABC transporter Comm PF15957.5 ETO24843.1 - 2.7 8.4 5.3 0.65 10.4 0.4 2.4 2 0 0 2 2 2 0 Commissureless DUF2992 PF11208.8 ETO24843.1 - 8.1 6.7 12.0 4.6 7.5 2.8 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2992) TPR_19 PF14559.6 ETO24844.1 - 7.7e-12 45.6 5.1 7.9e-07 29.5 3.5 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24844.1 - 6.9e-11 41.4 34.0 0.13 12.5 0.0 9.7 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24844.1 - 2.1e-10 40.8 22.1 0.00038 20.7 0.1 7.3 6 2 2 8 8 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24844.1 - 3.9e-10 39.4 2.4 2.6e-05 24.3 0.0 4.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24844.1 - 1.4e-08 34.2 26.0 0.46 10.4 0.0 9.0 9 0 0 9 9 9 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO24844.1 - 4.7e-08 33.5 2.0 1.1e-05 26.0 0.5 3.8 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24844.1 - 6.1e-08 32.9 4.2 0.007 17.1 0.0 5.9 6 1 2 8 8 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO24844.1 - 3e-07 30.1 24.0 0.0083 16.3 0.0 8.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24844.1 - 3.3e-05 23.6 4.9 3.6 7.8 0.0 6.4 7 0 0 7 7 6 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO24844.1 - 3.5e-05 23.5 17.0 0.5 10.3 0.1 6.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_20 PF14561.6 ETO24844.1 - 0.0011 19.2 0.5 0.041 14.2 1.8 2.6 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF4611 PF15387.6 ETO24844.1 - 0.01 16.1 0.1 0.027 14.7 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) ANAPC3 PF12895.7 ETO24844.1 - 0.019 15.2 1.1 0.019 15.2 1.1 5.3 4 3 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 eIF3g PF12353.8 ETO24844.1 - 0.09 13.2 2.7 0.13 12.6 0.5 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G PPR PF01535.20 ETO24844.1 - 0.12 12.7 1.7 46 4.6 0.0 4.2 4 0 0 4 4 4 0 PPR repeat TPR_11 PF13414.6 ETO24844.1 - 0.18 11.5 17.0 1.3 8.8 0.0 5.5 5 1 2 7 7 7 0 TPR repeat Sel1 PF08238.12 ETO24844.1 - 0.55 11.0 4.2 10 6.9 0.0 3.5 3 0 0 3 3 3 0 Sel1 repeat Kelch_3 PF13415.6 ETO24845.1 - 1.2e-06 28.6 0.1 1.4e-05 25.2 0.0 2.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24845.1 - 2.7e-06 26.9 6.4 5.2e-06 25.9 1.0 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO24845.1 - 4.6e-05 23.4 0.1 0.00024 21.0 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO24845.1 - 0.024 14.6 8.6 3.4 7.8 0.5 4.8 4 1 0 4 4 4 0 Kelch motif DKNYY PF13644.6 ETO24845.1 - 5.3 7.8 13.0 0.33 11.7 7.1 2.0 2 1 0 2 2 2 0 DKNYY family ECH_1 PF00378.20 ETO24846.1 - 1.3e-25 90.2 0.0 1.7e-25 89.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO24846.1 - 2.1e-09 37.3 0.0 2.6e-09 37.0 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase GP88 PF17338.2 ETO24847.1 - 0.097 12.1 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Gene product 88 Pkinase PF00069.25 ETO24848.1 - 2.4e-13 50.1 0.3 1.7e-07 30.9 0.2 2.3 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24848.1 - 0.0031 16.9 0.1 0.39 10.0 0.1 2.3 2 1 0 2 2 2 2 Protein tyrosine kinase ORC_WH_C PF18137.1 ETO24848.1 - 0.0031 17.6 0.2 0.0061 16.6 0.2 1.4 1 0 0 1 1 1 1 Origin recognition complex winged helix C-terminal Pkinase_fungal PF17667.1 ETO24848.1 - 0.0059 15.4 0.0 0.0082 15.0 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Orf78 PF06024.12 ETO24848.1 - 2.2 8.7 4.5 3 8.2 1.0 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Ank_2 PF12796.7 ETO24849.1 - 3.8e-18 65.9 1.4 2.2e-13 50.6 0.1 2.4 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO24849.1 - 3.8e-15 54.5 1.9 6.4e-05 23.1 0.0 4.2 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ETO24849.1 - 1.2e-14 54.4 0.5 1.9e-09 37.9 0.1 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO24849.1 - 2.9e-13 49.6 1.2 0.00046 20.5 0.0 4.3 5 0 0 5 5 5 3 Ankyrin repeat Ank_5 PF13857.6 ETO24849.1 - 4.6e-13 49.1 0.9 3.2e-05 24.1 0.0 3.5 1 1 2 3 3 3 3 Ankyrin repeats (many copies) Pro-rich_19 PF15455.6 ETO24849.1 - 0.014 14.5 0.0 0.018 14.2 0.0 1.1 1 0 0 1 1 1 0 Proline-rich 19 XPG_N PF00752.17 ETO24851.1 - 0.035 14.6 0.3 0.07 13.6 0.3 1.5 1 0 0 1 1 1 0 XPG N-terminal domain DUF2270 PF10028.9 ETO24851.1 - 0.038 13.6 0.2 0.055 13.0 0.2 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2270) UPF0242 PF06785.11 ETO24851.1 - 0.08 13.0 12.4 0.12 12.5 12.4 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2203 PF09969.9 ETO24851.1 - 0.44 11.3 4.9 3.4 8.4 0.2 2.4 1 1 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) LodA_N PF17990.1 ETO24851.1 - 0.47 10.4 2.9 0.65 9.9 2.8 1.3 1 1 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal DnaG_DnaB_bind PF08278.11 ETO24851.1 - 0.57 10.8 2.9 12 6.5 0.1 2.4 1 1 1 2 2 2 0 DNA primase DnaG DnaB-binding OrfB_IS605 PF01385.19 ETO24851.1 - 1.2 9.4 6.6 4 7.7 1.9 2.2 1 1 1 2 2 2 0 Probable transposase DUF1664 PF07889.12 ETO24851.1 - 6.7 6.8 9.4 14 5.8 3.3 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Dynactin PF12455.8 ETO24852.1 - 0.0045 16.3 1.9 0.0062 15.8 1.9 1.1 1 0 0 1 1 1 1 Dynein associated protein Filament PF00038.21 ETO24852.1 - 0.035 13.7 9.4 0.044 13.4 9.4 1.1 1 0 0 1 1 1 0 Intermediate filament protein Vinculin PF01044.19 ETO24852.1 - 0.039 12.2 2.3 0.046 12.0 2.3 1.2 1 0 0 1 1 1 0 Vinculin family Phage_int_SAM_1 PF02899.17 ETO24852.1 - 0.04 14.2 0.2 0.13 12.6 0.1 2.0 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Pyr_redox_3 PF13738.6 ETO24852.1 - 0.056 12.7 0.2 0.078 12.2 0.2 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Fib_alpha PF08702.10 ETO24852.1 - 0.1 12.8 10.4 0.22 11.7 2.9 2.3 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family SseC PF04888.12 ETO24852.1 - 0.16 11.5 2.7 0.28 10.7 0.5 2.1 2 0 0 2 2 2 0 Secretion system effector C (SseC) like family Tweety PF04906.13 ETO24852.1 - 0.19 10.4 2.4 0.25 10.0 2.4 1.1 1 0 0 1 1 1 0 Tweety DUF948 PF06103.11 ETO24852.1 - 0.2 11.9 5.4 16 5.8 0.9 2.9 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF668 PF05003.12 ETO24852.1 - 0.28 11.7 1.3 0.85 10.1 0.1 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF668) DUF1664 PF07889.12 ETO24852.1 - 0.29 11.2 2.4 1.4 9.0 1.8 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 ETO24852.1 - 0.35 11.1 4.2 0.23 11.7 1.2 1.9 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Fzo_mitofusin PF04799.13 ETO24852.1 - 0.41 10.2 7.5 0.43 10.1 1.1 2.3 1 1 1 2 2 2 0 fzo-like conserved region Laminin_II PF06009.12 ETO24852.1 - 0.41 10.6 7.9 0.55 10.2 2.3 2.2 1 1 1 2 2 2 0 Laminin Domain II Com_YlbF PF06133.11 ETO24852.1 - 0.63 10.7 6.8 1.6 9.4 1.0 2.4 2 0 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA UPF0449 PF15136.6 ETO24852.1 - 3.8 8.0 6.8 1 9.8 1.1 2.4 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 FapA PF03961.13 ETO24852.1 - 3.8 6.0 8.7 2.1 6.9 5.7 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A IZUMO PF15005.6 ETO24852.1 - 5.7 7.4 9.5 2.9 8.4 2.6 2.1 1 1 1 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated Pex19 PF04614.12 ETO24853.1 - 1.3e-08 34.9 0.6 1.3e-08 34.9 0.6 1.9 1 1 1 2 2 2 1 Pex19 protein family Rav1p_C PF12234.8 ETO24853.1 - 0.05 12.0 5.6 0.062 11.7 5.6 1.0 1 0 0 1 1 1 0 RAVE protein 1 C terminal Sec16_C PF12931.7 ETO24854.1 - 0.65 9.6 6.3 2.9 7.5 0.1 2.8 2 1 1 3 3 3 0 Sec23-binding domain of Sec16 ARL2_Bind_BART PF11527.8 ETO24854.1 - 9.5 6.4 9.0 1.5 9.0 0.8 3.4 3 1 1 4 4 4 0 The ARF-like 2 binding protein BART WD40 PF00400.32 ETO24855.1 - 1.9e-10 41.1 6.4 9.9e-05 23.0 0.9 4.2 4 1 0 4 4 4 2 WD domain, G-beta repeat PH PF00169.29 ETO24856.1 - 2e-15 57.2 0.1 3.8e-15 56.3 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO24856.1 - 0.00016 21.7 0.5 0.00031 20.8 0.1 1.7 1 1 1 2 2 2 1 PH domain PH_8 PF15409.6 ETO24856.1 - 0.0017 18.6 0.7 0.016 15.4 0.7 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO24856.1 - 0.0033 17.8 3.4 0.14 12.6 2.5 2.7 1 1 1 2 2 2 1 Pleckstrin homology domain PH_12 PF16457.5 ETO24856.1 - 0.033 14.7 0.3 0.13 12.8 0.0 2.0 2 0 0 2 2 2 0 Pleckstrin homology domain PH_13 PF16652.5 ETO24856.1 - 0.068 13.0 0.1 0.52 10.1 0.0 2.2 3 0 0 3 3 3 0 Pleckstrin homology domain ORC6 PF05460.13 ETO24857.1 - 0.0038 16.5 0.1 0.0038 16.5 0.1 1.1 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) FAM76 PF16046.5 ETO24857.1 - 0.0055 16.1 0.3 0.0062 15.9 0.3 1.1 1 0 0 1 1 1 1 FAM76 protein OATP PF03137.20 ETO24857.1 - 0.019 13.3 0.0 0.022 13.0 0.0 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family QLQ PF08880.11 ETO24857.1 - 0.024 14.4 0.3 0.06 13.1 0.3 1.7 1 0 0 1 1 1 0 QLQ DUF2937 PF11157.8 ETO24857.1 - 0.1 12.3 0.4 0.2 11.3 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) LapA_dom PF06305.11 ETO24857.1 - 0.2 11.5 1.6 0.76 9.6 1.6 2.1 1 1 0 1 1 1 0 Lipopolysaccharide assembly protein A domain RNA_pol_L PF01193.24 ETO24858.1 - 3.7e-10 39.1 0.0 5.6e-10 38.5 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb3/Rpb11 dimerisation domain RNA_pol_A_bac PF01000.26 ETO24858.1 - 1e-07 32.3 0.0 2.2e-07 31.2 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb3/RpoA insert domain Pex19 PF04614.12 ETO24859.1 - 9.6e-09 35.4 8.8 9.6e-09 35.4 8.8 2.3 1 1 1 2 2 2 1 Pex19 protein family CDC45 PF02724.14 ETO24860.1 - 0.0048 15.3 9.4 0.0051 15.2 9.4 1.2 1 0 0 1 1 1 1 CDC45-like protein DUF4524 PF15025.6 ETO24860.1 - 0.047 13.4 0.6 0.1 12.4 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4524) HsdM_N PF12161.8 ETO24860.1 - 0.24 12.0 4.1 0.5 11.0 4.1 1.5 1 0 0 1 1 1 0 HsdM N-terminal domain DUF87 PF01935.17 ETO24860.1 - 1.1 9.3 6.9 1.6 8.8 5.2 1.9 2 0 0 2 2 2 0 Helicase HerA, central domain Peptidase_S49_N PF08496.10 ETO24860.1 - 1.9 8.5 6.1 3.5 7.7 6.1 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Presenilin PF01080.17 ETO24860.1 - 3.8 6.2 11.0 4.4 6.0 11.0 1.1 1 0 0 1 1 1 0 Presenilin GTP_EFTU_D2 PF03144.25 ETO24861.1 - 0.00013 22.3 0.3 0.00043 20.6 0.3 2.0 1 0 0 1 1 1 1 Elongation factor Tu domain 2 DUF1858 PF08984.11 ETO24861.1 - 0.15 12.2 0.0 18 5.6 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1858) Coatomer_WDAD PF04053.14 ETO24862.1 - 1.1e-105 354.2 0.2 1.7e-105 353.6 0.2 1.2 1 0 0 1 1 1 1 Coatomer WD associated region TPR_16 PF13432.6 ETO24863.1 - 4.4e-12 46.5 4.2 1.4e-06 28.9 1.6 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO24863.1 - 1.4e-11 43.5 18.6 6.8e-05 22.7 0.9 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO24863.1 - 1.2e-10 40.8 18.4 1.2e-05 24.9 1.0 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO24863.1 - 2.6e-09 37.1 2.8 0.00039 21.0 0.1 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO24863.1 - 1.4e-08 35.1 1.0 0.085 13.4 0.3 3.6 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO24863.1 - 8e-08 31.8 1.6 0.022 14.4 0.3 3.5 2 1 1 3 3 3 3 TPR repeat TPR_8 PF13181.6 ETO24863.1 - 2.8e-07 30.2 16.3 4.7e-05 23.3 0.5 4.7 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO24863.1 - 3.1e-07 30.3 1.6 0.022 15.1 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO24863.1 - 4.3e-06 26.4 7.8 0.00042 20.1 0.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO24863.1 - 0.0001 22.5 7.8 0.042 14.2 2.1 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_15 PF13429.6 ETO24863.1 - 0.0011 18.2 4.6 0.016 14.4 0.4 2.4 2 1 1 3 3 3 2 Tetratricopeptide repeat RPN7 PF10602.9 ETO24863.1 - 0.0018 18.0 2.7 0.053 13.2 0.2 2.9 1 1 1 2 2 2 1 26S proteasome subunit RPN7 ANAPC3 PF12895.7 ETO24863.1 - 0.0021 18.3 7.9 0.29 11.4 2.8 2.9 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_6 PF13174.6 ETO24863.1 - 0.0025 18.4 13.1 0.37 11.5 0.3 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat PPR PF01535.20 ETO24863.1 - 0.014 15.6 0.8 0.057 13.7 0.1 2.4 2 0 0 2 2 2 0 PPR repeat DUF3669 PF12417.8 ETO24863.1 - 0.035 14.3 0.5 7.9 6.8 0.2 2.6 1 1 1 2 2 2 0 Zinc finger protein BTAD PF03704.17 ETO24863.1 - 0.13 12.6 1.9 0.18 12.3 0.6 1.8 1 1 1 2 2 2 0 Bacterial transcriptional activator domain Gly-rich_Ago1 PF12764.7 ETO24865.1 - 0.062 14.1 1.9 0.11 13.3 1.9 1.3 1 0 0 1 1 1 0 Glycine-rich region of argonaut HNF-1_N PF04814.13 ETO24867.1 - 0.032 14.9 8.6 0.41 11.3 0.0 2.4 2 0 0 2 2 2 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Tir_receptor_C PF07489.11 ETO24867.1 - 0.31 11.0 11.0 0.49 10.3 11.0 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Mucin PF01456.17 ETO24867.1 - 1.1 9.3 13.7 1.9 8.4 13.7 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein TFIIA PF03153.13 ETO24868.1 - 0.0086 16.1 9.8 0.01 15.9 9.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF2140 PF09911.9 ETO24868.1 - 0.017 14.7 1.4 2.4 7.7 0.3 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2140) SpoIIIAH PF12685.7 ETO24868.1 - 0.018 14.9 0.3 0.023 14.5 0.3 1.2 1 0 0 1 1 1 0 SpoIIIAH-like protein Ndc1_Nup PF09531.10 ETO24868.1 - 0.048 12.4 3.2 0.058 12.1 3.2 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ETO24868.1 - 0.36 9.5 4.2 0.48 9.1 4.2 1.2 1 0 0 1 1 1 0 Presenilin PAT1 PF09770.9 ETO24868.1 - 0.78 7.9 10.7 1.1 7.5 10.7 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SOG2 PF10428.9 ETO24868.1 - 1.1 8.4 12.4 1.4 8.0 12.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Shisa PF13908.6 ETO24868.1 - 3.8 7.7 7.4 6.6 6.9 7.4 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Roughex PF06020.11 ETO24868.1 - 4.1 6.4 7.3 6.7 5.7 7.3 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Herpes_DNAp_acc PF04929.12 ETO24868.1 - 4.3 6.2 11.1 7.3 5.4 11.1 1.3 1 0 0 1 1 1 0 Herpes DNA replication accessory factor Pex14_N PF04695.13 ETO24868.1 - 6.8 7.3 17.6 11 6.6 17.6 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Secretin_N_2 PF07655.13 ETO24869.1 - 3.2 8.4 16.3 6.3 7.4 4.7 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain Misat_Tub_SegII PF10644.9 ETO24872.1 - 3.3e-12 46.7 3.9 5.2e-08 33.2 0.9 2.7 1 1 0 2 2 2 2 Misato Segment II tubulin-like domain Kelch_4 PF13418.6 ETO24873.1 - 2.6e-27 94.6 0.2 9.6e-10 38.3 0.0 3.1 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO24873.1 - 1.3e-22 79.3 1.2 5.3e-08 32.9 0.3 3.2 2 1 1 3 3 3 3 Kelch motif Kelch_5 PF13854.6 ETO24873.1 - 5.7e-20 70.9 0.0 5.4e-06 26.3 0.1 3.4 3 0 0 3 3 3 3 Kelch motif Kelch_3 PF13415.6 ETO24873.1 - 1.4e-18 66.7 0.1 1.2e-06 28.7 0.0 3.2 3 0 0 3 3 3 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24873.1 - 1.3e-16 59.9 0.1 1.5e-07 30.8 0.0 3.2 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ETO24873.1 - 9.1e-11 41.3 0.6 0.0053 16.7 0.0 3.3 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ETO24874.1 - 3.6e-05 23.7 0.1 7.3e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Pkinase PF00069.25 ETO24874.1 - 0.00025 20.5 0.0 0.00035 20.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kelch_3 PF13415.6 ETO24874.1 - 0.027 14.8 0.0 4.8 7.6 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24874.1 - 0.091 12.4 0.0 0.26 10.9 0.0 1.7 2 0 0 2 2 2 0 Kelch motif CPSF_A PF03178.15 ETO24875.1 - 1.4e-41 142.8 0.8 5e-18 65.5 0.1 3.2 3 0 0 3 3 3 3 CPSF A subunit region CDC45 PF02724.14 ETO24875.1 - 5.5e-05 21.7 10.5 5.5e-05 21.7 10.5 3.0 2 1 1 3 3 3 1 CDC45-like protein CNDH2_C PF16858.5 ETO24875.1 - 0.0019 18.1 6.1 0.0019 18.1 6.1 2.9 2 1 0 2 2 2 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term DUF2722 PF10846.8 ETO24875.1 - 0.0036 16.3 10.3 0.0036 16.3 10.3 2.5 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) Motilin_ghrelin PF04644.12 ETO24875.1 - 2.8 7.8 8.9 0.09 12.6 0.5 2.7 2 0 0 2 2 2 0 Motilin/ghrelin CCDC24 PF15669.5 ETO24876.1 - 0.024 14.5 0.3 0.029 14.2 0.3 1.1 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DUF1643 PF07799.12 ETO24877.1 - 0.021 15.0 0.0 0.03 14.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1643) Mannosyl_trans3 PF11051.8 ETO24877.1 - 0.048 13.0 0.1 0.054 12.9 0.1 1.3 1 0 0 1 1 1 0 Mannosyltransferase putative PUB PF09409.10 ETO24878.1 - 8.2e-09 35.3 0.1 2.2e-08 33.9 0.0 1.8 2 0 0 2 2 2 1 PUB domain PRD PF00874.20 ETO24879.1 - 0.045 14.0 1.7 0.045 14.0 1.7 4.2 1 1 2 4 4 4 0 PRD domain YvrJ PF12841.7 ETO24879.1 - 0.55 9.8 4.1 3.6 7.2 0.1 3.4 3 0 0 3 3 3 0 YvrJ protein family Baculo_PEP_C PF04513.12 ETO24879.1 - 2.8 8.0 15.3 0.94 9.5 0.2 3.8 1 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Tup_N PF08581.10 ETO24879.1 - 3.5 8.0 54.1 0.4 11.0 5.2 5.8 2 2 3 6 6 6 0 Tup N-terminal GCV_T PF01571.21 ETO24881.1 - 0.063 12.6 0.0 0.11 11.8 0.0 1.4 1 0 0 1 1 1 0 Aminomethyltransferase folate-binding domain Arginase PF00491.21 ETO24882.1 - 3.6e-50 171.0 0.0 4.3e-50 170.8 0.0 1.0 1 0 0 1 1 1 1 Arginase family UPF0489 PF12640.7 ETO24882.1 - 0.028 14.7 0.3 0.25 11.6 0.0 2.1 1 1 0 2 2 2 0 UPF0489 domain MOZART1 PF12554.8 ETO24882.1 - 0.16 11.8 0.8 1.4 8.8 0.2 2.6 2 0 0 2 2 2 0 Mitotic-spindle organizing gamma-tubulin ring associated WD40 PF00400.32 ETO24883.1 - 1.2e-126 408.9 34.7 2.6e-11 43.9 0.1 14.2 14 0 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24883.1 - 2.7e-49 165.4 9.9 0.00012 22.3 0.0 12.1 2 2 8 11 11 11 11 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO24883.1 - 1.4e-28 100.2 5.3 0.00048 19.6 0.1 7.4 4 2 2 7 7 7 7 WD40-like domain Ge1_WD40 PF16529.5 ETO24883.1 - 8.1e-23 80.9 3.8 0.0048 15.9 0.0 10.6 3 3 7 10 10 10 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO24883.1 - 5.2e-17 61.7 16.1 0.33 9.6 0.1 10.2 1 1 6 10 10 10 7 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO24883.1 - 2.8e-11 43.5 4.0 0.0076 15.9 0.1 5.1 2 2 2 5 5 5 3 PQQ-like domain Cytochrom_D1 PF02239.16 ETO24883.1 - 1.1e-09 37.3 6.2 0.022 13.3 0.0 5.2 2 2 4 7 7 7 4 Cytochrome D1 heme domain PD40 PF07676.12 ETO24883.1 - 7.3e-09 35.3 9.0 6.6 6.8 0.0 10.3 11 0 0 11 11 11 2 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO24883.1 - 4.3e-07 29.5 0.1 28 4.9 0.0 7.9 8 0 0 8 8 8 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO24883.1 - 1.3e-06 27.6 7.2 0.73 8.7 0.0 7.0 3 2 4 8 8 8 2 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO24883.1 - 1.9e-06 27.5 3.9 3.4 6.9 0.0 6.1 2 2 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO24883.1 - 3.1e-06 26.2 1.2 5.8 5.6 0.0 6.7 2 2 5 7 7 7 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PS_Dcarbxylase PF02666.15 ETO24883.1 - 0.0015 18.1 2.5 0.97 8.9 0.0 4.5 4 1 1 5 5 5 1 Phosphatidylserine decarboxylase VID27 PF08553.10 ETO24883.1 - 0.0032 16.6 0.7 3.6 6.6 0.0 3.8 2 2 1 3 3 3 1 VID27 C-terminal WD40-like domain FmdE PF02663.14 ETO24883.1 - 0.034 14.2 0.1 3.2 7.8 0.0 3.5 3 1 0 3 3 3 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon DUF3748 PF12566.8 ETO24883.1 - 0.037 14.0 0.3 8.2 6.4 0.0 4.5 3 2 2 5 5 5 0 Protein of unknown function (DUF3748) DUF1854 PF08909.11 ETO24883.1 - 0.045 13.6 4.6 0.37 10.6 0.1 4.3 5 1 1 6 6 6 0 Domain of unknown function (DUF1854) Fib_alpha PF08702.10 ETO24883.1 - 0.15 12.3 3.4 0.086 13.0 0.5 1.9 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Proteasome_A_N PF10584.9 ETO24883.1 - 9.4 6.0 15.8 36 4.2 0.1 6.9 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature TIG PF01833.24 ETO24884.1 - 0.007 16.4 2.6 0.022 14.8 0.7 2.6 2 0 0 2 2 2 1 IPT/TIG domain PapC_N PF13954.6 ETO24884.1 - 0.056 13.5 0.1 0.098 12.7 0.1 1.3 1 0 0 1 1 1 0 PapC N-terminal domain POT1 PF02765.17 ETO24885.1 - 3.6e-10 39.8 0.1 3.6e-10 39.8 0.1 2.7 3 0 0 3 3 3 1 Telomeric single stranded DNA binding POT1/CDC13 tRNA_anti-codon PF01336.25 ETO24885.1 - 0.0018 18.2 0.3 0.22 11.5 0.0 2.8 2 0 0 2 2 2 1 OB-fold nucleic acid binding domain POT1PC PF16686.5 ETO24885.1 - 0.016 15.1 0.6 0.77 9.6 0.2 3.5 3 1 0 3 3 3 0 ssDNA-binding domain of telomere protection protein RMI1_C PF16099.5 ETO24885.1 - 0.033 14.0 0.0 0.49 10.2 0.0 2.4 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold Kinesin PF00225.23 ETO24886.1 - 2.6e-61 207.4 0.7 3.3e-61 207.1 0.7 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO24886.1 - 2.4e-15 56.8 0.4 9.6e-14 51.6 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding PriX PF18689.1 ETO24886.1 - 0.014 15.7 0.1 1.6 9.1 0.0 2.4 2 0 0 2 2 2 0 Primase X AAA_16 PF13191.6 ETO24886.1 - 0.034 14.5 0.2 0.62 10.4 0.2 2.6 1 1 0 1 1 1 0 AAA ATPase domain PABP PF00658.18 ETO24888.1 - 3.1e-09 36.9 2.5 9.6e-09 35.3 0.1 2.5 2 0 0 2 2 2 1 Poly-adenylate binding protein, unique domain SR-25 PF10500.9 ETO24888.1 - 0.32 10.6 13.4 0.72 9.4 13.4 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 ETO24888.1 - 1.1 7.9 7.7 2.1 7.1 7.7 1.4 1 0 0 1 1 1 0 Presenilin IMUP PF15761.5 ETO24888.1 - 1.3 9.7 9.8 3.8 8.2 9.8 1.7 1 0 0 1 1 1 0 Immortalisation up-regulated protein DUF4031 PF13223.6 ETO24889.1 - 0.022 15.0 0.0 0.039 14.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4031) Presenilin PF01080.17 ETO24891.1 - 3.1 6.4 6.2 3.5 6.3 6.2 1.1 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 ETO24891.1 - 4.9 7.8 25.5 0.67 10.5 18.4 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain DUF4175 PF13779.6 ETO24892.1 - 7.4 4.3 26.6 8.8 4.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4175) Nucleotid_trans PF03407.16 ETO24893.1 - 3.9e-17 62.9 0.3 1.4e-16 61.2 0.3 1.9 1 1 0 1 1 1 1 Nucleotide-diphospho-sugar transferase Raf1_HTH PF18579.1 ETO24893.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 1 0 0 1 1 1 0 Rubisco accumulation factor 1 helix turn helix domain Peptidase_C14 PF00656.22 ETO24895.1 - 3.5e-13 50.1 0.9 9e-13 48.7 0.9 1.7 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO24895.1 - 0.0013 18.7 0.6 2.1 8.4 0.0 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO24895.1 - 0.033 14.5 2.7 2.7 8.4 0.1 4.1 4 0 0 4 4 4 0 Kelch motif RNA_pol_Rpb1_5 PF04998.17 ETO24895.1 - 5.3 6.4 7.1 0.78 9.1 0.7 2.4 2 0 0 2 2 2 0 RNA polymerase Rpb1, domain 5 DnaJ_C PF01556.18 ETO24897.1 - 3.1e-15 56.5 0.3 5.6e-15 55.7 0.3 1.4 1 0 0 1 1 1 1 DnaJ C terminal domain ABC_export PF16962.5 ETO24898.1 - 0.049 12.1 0.0 0.077 11.4 0.0 1.2 1 0 0 1 1 1 0 Putative ABC exporter Mem_trans PF03547.18 ETO24898.1 - 0.21 9.9 1.0 3.6 5.9 0.1 2.1 2 0 0 2 2 2 0 Membrane transport protein FAM176 PF14851.6 ETO24898.1 - 0.47 10.1 2.4 2.7 7.7 0.0 2.6 2 0 0 2 2 2 0 FAM176 family MAP17 PF15807.5 ETO24898.1 - 1.1 9.5 7.4 1.3 9.3 0.3 2.8 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Zip PF02535.22 ETO24898.1 - 1.1 8.4 5.8 3.9 6.6 0.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter WD40 PF00400.32 ETO24900.1 - 3e-29 100.6 28.7 1.6e-06 28.7 2.1 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24900.1 - 3.1e-12 46.6 4.4 0.046 14.0 0.0 6.0 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO24900.1 - 4.8e-08 32.1 4.3 0.06 12.0 0.0 4.8 2 1 2 5 5 5 4 Nucleoporin Nup120/160 WYL_2 PF10902.8 ETO24900.1 - 0.15 12.4 0.4 15 6.1 0.2 3.6 4 0 0 4 4 4 0 WYL_2, Sm-like SH3 beta-barrel fold p450 PF00067.22 ETO24901.1 - 4.8e-51 173.9 0.1 6.3e-51 173.6 0.1 1.0 1 0 0 1 1 1 1 Cytochrome P450 Hydrolase_4 PF12146.8 ETO24902.1 - 1.5e-09 37.5 0.2 5.7e-08 32.3 0.2 2.1 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Peptidase_S9 PF00326.21 ETO24902.1 - 1.2e-05 24.8 0.0 0.00049 19.6 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETO24902.1 - 1.7e-05 24.7 0.4 0.086 12.6 0.0 3.1 3 0 0 3 3 3 2 Phospholipase/Carboxylesterase Abhydrolase_1 PF00561.20 ETO24902.1 - 3.7e-05 23.5 1.6 0.00029 20.5 1.6 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_3 PF07859.13 ETO24902.1 - 4.1e-05 23.5 0.0 8.2e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO24902.1 - 0.00045 20.9 0.0 0.00054 20.6 0.0 1.3 1 1 0 1 1 1 1 Alpha/beta hydrolase family Chlorophyllase2 PF12740.7 ETO24902.1 - 0.0066 15.4 0.0 0.0095 14.9 0.0 1.2 1 0 0 1 1 1 1 Chlorophyllase enzyme BAAT_C PF08840.11 ETO24902.1 - 0.0093 15.9 0.6 0.9 9.4 0.1 2.1 1 1 1 2 2 2 1 BAAT / Acyl-CoA thioester hydrolase C terminal UPF0227 PF05728.12 ETO24902.1 - 0.0098 15.9 0.4 0.45 10.4 0.2 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0227) Peptidase_S15 PF02129.18 ETO24902.1 - 0.024 14.2 0.1 0.054 13.1 0.1 1.4 1 1 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) PARP PF00644.20 ETO24902.1 - 0.081 12.5 0.1 7.5 6.1 0.0 2.9 3 0 0 3 3 3 0 Poly(ADP-ribose) polymerase catalytic domain HSP70 PF00012.20 ETO24903.1 - 1.6e-22 79.5 2.0 6.6e-22 77.4 2.0 1.8 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO24903.1 - 0.00017 20.5 0.0 0.00075 18.4 0.0 1.8 2 0 0 2 2 2 1 MreB/Mbl protein MutS_III PF05192.18 ETO24904.1 - 1.4e-24 87.4 4.0 2.5e-24 86.6 4.0 1.4 1 0 0 1 1 1 1 MutS domain III MutS_V PF00488.21 ETO24904.1 - 3.4e-11 43.5 0.1 6.7e-11 42.6 0.1 1.5 1 0 0 1 1 1 1 MutS domain V MutS_IV PF05190.18 ETO24904.1 - 1.1e-05 25.7 0.2 3.1e-05 24.2 0.2 1.9 1 0 0 1 1 1 1 MutS family domain IV AAA_14 PF13173.6 ETO24904.1 - 0.041 13.9 0.8 0.41 10.7 0.1 2.8 2 0 0 2 2 2 0 AAA domain Pkinase PF00069.25 ETO24906.1 - 3.3e-59 200.4 0.0 4.2e-59 200.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24906.1 - 2.4e-28 99.2 0.0 3.2e-28 98.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO24906.1 - 3.3e-05 23.3 0.0 5.5e-05 22.6 0.0 1.4 1 1 0 1 1 1 1 Kinase-like cNMP_binding PF00027.29 ETO24907.1 - 1.4e-11 44.3 0.5 1e-06 28.7 0.0 3.4 3 0 0 3 3 3 2 Cyclic nucleotide-binding domain CBM39 PF15886.5 ETO24907.1 - 0.0057 16.5 1.9 0.018 14.9 0.0 2.4 2 0 0 2 2 2 1 Carbohydrate binding domain (family 32) CDC45 PF02724.14 ETO24907.1 - 0.036 12.4 9.7 0.045 12.1 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO24907.1 - 0.11 11.0 5.3 0.15 10.6 5.3 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 FSA_C PF10479.9 ETO24907.1 - 0.16 10.1 6.3 0.22 9.6 6.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Atrophin-1 PF03154.15 ETO24907.1 - 0.74 8.0 14.4 0.98 7.6 14.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family DUF572 PF04502.13 ETO24907.1 - 0.78 9.3 17.4 1.5 8.4 17.4 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF572) SSP160 PF06933.11 ETO24907.1 - 1.8 6.7 19.9 2.8 6.0 19.9 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TFIIF_alpha PF05793.12 ETO24907.1 - 4.1 5.9 26.7 0.14 10.7 19.7 1.8 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) GREB1 PF15782.5 ETO24907.1 - 7.4 3.5 15.4 9.6 3.2 15.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer POP1 PF06978.11 ETO24907.1 - 9.3 6.2 12.5 1.4 8.9 8.5 1.6 2 0 0 2 2 2 0 Ribonucleases P/MRP protein subunit POP1 PH PF00169.29 ETO24908.1 - 0.00021 21.8 0.3 0.00021 21.8 0.3 2.3 2 2 0 2 2 2 1 PH domain CLU PF13236.6 ETO24908.1 - 0.0093 15.8 0.0 0.021 14.6 0.0 1.6 1 0 0 1 1 1 1 Clustered mitochondria Cyt-b5 PF00173.28 ETO24909.1 - 4.7e-11 42.7 0.0 9.4e-11 41.7 0.0 1.5 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain WD40 PF00400.32 ETO24911.1 - 8.8e-10 39.0 9.8 0.57 11.1 0.0 6.3 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24911.1 - 0.0006 20.1 0.5 2.9 8.3 0.0 3.5 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain FH2 PF02181.23 ETO24912.1 - 3.1e-66 224.0 8.7 3.1e-66 224.0 8.7 3.4 2 1 0 3 3 3 1 Formin Homology 2 Domain CCDC53 PF10152.9 ETO24912.1 - 0.00044 20.7 0.3 0.00044 20.7 0.3 6.7 4 2 0 4 4 4 1 Subunit CCDC53 of WASH complex Caldesmon PF02029.15 ETO24912.1 - 0.00065 18.6 56.5 0.00065 18.6 56.5 2.9 3 0 0 3 3 3 1 Caldesmon SSP160 PF06933.11 ETO24912.1 - 7.2 4.7 8.9 14 3.7 8.9 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Drf_GBD PF06371.13 ETO24913.1 - 6e-05 22.7 0.1 7.2e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Diaphanous GTPase-binding Domain PHAT PF09246.10 ETO24913.1 - 0.08 12.8 0.0 0.093 12.6 0.0 1.1 1 0 0 1 1 1 0 PHAT PI3_PI4_kinase PF00454.27 ETO24915.1 - 0.00055 19.8 4.3 0.0077 16.1 0.8 2.4 2 1 0 2 2 2 2 Phosphatidylinositol 3- and 4-kinase Vps51 PF08700.11 ETO24915.1 - 0.056 13.5 0.7 4.6 7.4 0.1 2.4 2 0 0 2 2 2 0 Vps51/Vps67 Menin PF05053.13 ETO24917.1 - 0.065 11.6 3.8 0.057 11.8 3.8 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO24917.1 - 0.26 10.0 5.5 0.24 10.1 5.5 1.2 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO24917.1 - 0.86 8.3 8.9 1.1 8.0 8.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Glyco_transf_92 PF01697.27 ETO24918.1 - 2.3e-17 63.5 5.1 4.8e-17 62.5 5.1 1.5 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO24918.1 - 0.00021 21.8 4.3 0.0005 20.5 2.5 2.5 2 1 0 2 2 2 1 Glycosyl transferase family 2 DUF3439 PF11921.8 ETO24919.1 - 0.021 14.8 0.8 0.044 13.7 0.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 ETO24920.1 - 1.3e-10 41.2 0.0 2.1e-10 40.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain SDA1 PF05285.12 ETO24922.1 - 2.2e-06 27.4 1.5 2.2e-06 27.4 1.5 1.1 1 0 0 1 1 1 1 SDA1 RRN3 PF05327.11 ETO24922.1 - 7.5e-05 21.5 0.7 7.5e-05 21.5 0.7 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 CDC45 PF02724.14 ETO24922.1 - 0.00014 20.3 0.3 0.00014 20.3 0.3 1.1 1 0 0 1 1 1 1 CDC45-like protein Connexin PF00029.19 ETO24922.1 - 0.00039 20.3 1.2 0.00052 19.8 0.4 1.5 2 0 0 2 2 2 1 Connexin NPR3 PF03666.13 ETO24922.1 - 0.00053 18.9 0.3 0.00055 18.8 0.3 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 ETO24922.1 - 0.014 14.4 0.0 0.014 14.4 0.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TMCO5 PF14992.6 ETO24922.1 - 0.023 14.3 2.1 0.041 13.5 2.1 1.5 1 1 0 1 1 1 0 TMCO5 family Pes-10 PF07149.11 ETO24922.1 - 0.037 13.1 5.4 0.048 12.7 5.4 1.1 1 0 0 1 1 1 0 Pes-10 Trypan_PARP PF05887.11 ETO24922.1 - 0.15 12.0 6.2 0.24 11.4 6.2 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MCM_bind PF09739.9 ETO24922.1 - 0.51 8.7 6.4 0.63 8.4 6.4 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor CobT PF06213.12 ETO24922.1 - 0.54 9.6 9.8 0.69 9.3 9.8 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT FancD2 PF14631.6 ETO24922.1 - 0.55 7.6 5.7 0.68 7.3 5.7 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PBP1_TM PF14812.6 ETO24922.1 - 1.1 9.6 22.5 1 9.8 19.2 2.3 1 1 1 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal TRAP_alpha PF03896.16 ETO24922.1 - 2.1 7.5 8.3 1.3 8.2 6.4 1.6 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DNA_pol_phi PF04931.13 ETO24922.1 - 2.7 6.0 15.7 3.4 5.6 15.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi Striatin PF08232.12 ETO24922.1 - 2.7 8.6 10.2 4.6 7.8 10.2 1.3 1 0 0 1 1 1 0 Striatin family Afi1 PF07792.12 ETO24922.1 - 3.3 8.2 11.2 8.5 6.9 9.8 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nop14 PF04147.12 ETO24922.1 - 3.4 5.8 18.6 4.4 5.4 18.6 1.1 1 0 0 1 1 1 0 Nop14-like family RPN2_C PF18004.1 ETO24922.1 - 4.3 7.2 13.2 8.5 6.3 13.2 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NOA36 PF06524.12 ETO24922.1 - 4.3 6.6 16.8 5.7 6.2 16.8 1.1 1 0 0 1 1 1 0 NOA36 protein Sporozoite_P67 PF05642.11 ETO24922.1 - 8.9 4.2 15.1 12 3.8 15.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Vps53_N PF04100.12 ETO24923.1 - 0.017 14.1 0.0 0.028 13.4 0.0 1.3 1 0 0 1 1 1 0 Vps53-like, N-terminal RGS PF00615.19 ETO24923.1 - 0.064 13.5 2.9 2.8 8.2 2.9 2.4 1 1 0 1 1 1 0 Regulator of G protein signaling domain Microtub_bd PF16796.5 ETO24923.1 - 0.077 12.9 0.0 0.1 12.5 0.0 1.3 1 0 0 1 1 1 0 Microtubule binding Choline_transpo PF04515.12 ETO24923.1 - 0.088 12.0 1.0 0.13 11.4 1.0 1.2 1 0 0 1 1 1 0 Plasma-membrane choline transporter Sec2p PF06428.11 ETO24923.1 - 0.14 12.1 0.1 0.24 11.4 0.1 1.3 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p ATG16 PF08614.11 ETO24925.1 - 0.0029 17.9 1.5 0.0029 17.9 1.5 2.2 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) DUF641 PF04859.12 ETO24925.1 - 0.0071 16.7 0.7 0.018 15.4 0.7 1.7 1 0 0 1 1 1 1 Plant protein of unknown function (DUF641) PKcGMP_CC PF16808.5 ETO24925.1 - 0.013 15.3 2.6 0.013 15.3 2.6 2.0 2 0 0 2 2 1 0 Coiled-coil N-terminus of cGMP-dependent protein kinase OmpH PF03938.14 ETO24925.1 - 0.014 15.7 0.7 0.014 15.7 0.7 1.9 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Tropomyosin_1 PF12718.7 ETO24925.1 - 0.015 15.5 4.4 0.015 15.5 4.4 2.1 2 0 0 2 2 2 0 Tropomyosin like CCDC-167 PF15188.6 ETO24925.1 - 0.022 15.1 1.7 0.022 15.1 1.7 2.2 2 0 0 2 2 1 0 Coiled-coil domain-containing protein 167 GLE1 PF07817.13 ETO24925.1 - 0.024 13.8 1.8 0.039 13.1 1.0 1.7 1 1 1 2 2 2 0 GLE1-like protein NOZZLE PF08744.10 ETO24925.1 - 0.043 13.3 0.5 0.082 12.4 0.1 1.6 2 0 0 2 2 2 0 Plant transcription factor NOZZLE MetOD2 PF18548.1 ETO24925.1 - 0.13 12.4 1.7 0.53 10.4 1.7 2.0 1 1 1 2 2 2 0 Metanogen output domain 2 HR1 PF02185.16 ETO24925.1 - 0.14 12.2 6.5 0.068 13.3 3.0 2.4 2 1 0 2 2 2 0 Hr1 repeat MBR1 PF17058.5 ETO24925.1 - 0.68 10.2 10.7 0.045 14.1 1.3 2.6 2 1 0 2 2 2 0 Mitochondrial biogenesis regulation protein 1 Spc24 PF08286.11 ETO24925.1 - 0.76 10.0 5.5 0.53 10.5 1.1 2.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Fez1 PF06818.15 ETO24925.1 - 0.99 9.8 12.0 0.12 12.8 5.7 2.2 2 0 0 2 2 2 0 Fez1 FAM176 PF14851.6 ETO24925.1 - 1.1 8.9 6.1 0.11 12.1 1.0 1.9 2 0 0 2 2 2 0 FAM176 family DUF4140 PF13600.6 ETO24925.1 - 4.9 7.7 6.8 6 7.4 0.6 2.5 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) zf-RanBP PF00641.18 ETO24926.1 - 1.6e-07 30.5 27.1 0.0031 16.8 3.7 3.7 2 1 1 3 3 3 3 Zn-finger in Ran binding protein and others DZR PF12773.7 ETO24926.1 - 0.0011 18.9 18.9 0.005 16.8 7.4 2.7 1 1 2 3 3 3 3 Double zinc ribbon DSPc PF00782.20 ETO24927.1 - 3.3e-20 72.3 0.9 4.5e-07 29.7 0.0 3.5 3 0 0 3 3 3 3 Dual specificity phosphatase, catalytic domain OrsD PF12013.8 ETO24927.1 - 0.72 10.3 6.9 3.4 8.2 0.6 2.8 3 0 0 3 3 3 0 Orsellinic acid/F9775 biosynthesis cluster protein D G-alpha PF00503.20 ETO24928.1 - 6.3e-20 71.6 0.1 7.5e-20 71.4 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Mito_carr PF00153.27 ETO24928.1 - 0.13 12.2 0.0 0.22 11.5 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial carrier protein Fig1 PF12351.8 ETO24929.1 - 1.3e-05 25.3 0.4 4.2e-05 23.6 0.4 1.9 1 0 0 1 1 1 1 Ca2+ regulator and membrane fusion protein Fig1 Staphylokinase PF02821.16 ETO24929.1 - 0.021 15.3 0.0 0.18 12.2 0.0 2.5 2 1 0 2 2 2 0 Staphylokinase/Streptokinase family CENP-U PF13097.6 ETO24929.1 - 0.1 12.6 0.1 0.24 11.4 0.1 1.5 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit TMF_DNA_bd PF12329.8 ETO24930.1 - 0.027 14.4 23.5 0.027 14.4 23.5 2.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding Phage_GPO PF05929.11 ETO24930.1 - 0.23 11.1 14.9 0.25 10.9 14.9 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase AHH PF14412.6 ETO24930.1 - 3.7 7.6 15.9 2 8.5 3.1 2.3 2 1 0 2 2 2 0 A nuclease family of the HNH/ENDO VII superfamily with conserved AHH DUF4407 PF14362.6 ETO24930.1 - 7.7 5.8 14.7 10 5.4 14.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Vps4_C PF09336.10 ETO24931.1 - 2e-23 82.1 0.1 5.3e-23 80.8 0.0 1.6 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ETO24931.1 - 0.0061 16.3 0.0 0.01 15.6 0.0 1.4 1 0 0 1 1 1 1 AAA+ lid domain Chromo PF00385.24 ETO24932.1 - 1e-05 25.3 0.9 1.9e-05 24.4 0.9 1.6 1 1 0 1 1 1 1 Chromo (CHRromatin Organisation MOdifier) domain DUF4611 PF15387.6 ETO24932.1 - 0.53 10.5 5.0 1.1 9.5 5.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) RGS PF00615.19 ETO24933.1 - 0.077 13.3 0.1 0.27 11.5 0.0 1.8 2 1 0 2 2 2 0 Regulator of G protein signaling domain Herpes_UL49_1 PF03117.14 ETO24934.1 - 0.11 11.8 0.1 0.14 11.5 0.1 1.1 1 0 0 1 1 1 0 UL49 family Ion_trans PF00520.31 ETO24935.1 - 3e-09 36.5 3.5 3e-09 36.5 3.5 1.8 2 0 0 2 2 2 1 Ion transport protein Zip PF02535.22 ETO24935.1 - 0.0024 17.2 0.0 0.0034 16.7 0.0 1.4 1 1 0 1 1 1 1 ZIP Zinc transporter PhoLip_ATPase_C PF16212.5 ETO24935.1 - 0.19 11.4 7.9 0.51 10.0 7.9 1.7 1 1 0 1 1 1 0 Phospholipid-translocating P-type ATPase C-terminal C2 PF00168.30 ETO24936.1 - 1.6e-10 41.2 0.1 4.1e-10 39.9 0.1 1.7 1 0 0 1 1 1 1 C2 domain TMEM169 PF15052.6 ETO24936.1 - 0.11 12.7 0.0 0.2 11.8 0.0 1.4 1 0 0 1 1 1 0 TMEM169 protein family DUF789 PF05623.12 ETO24936.1 - 0.3 10.7 8.4 0.25 11.0 6.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF789) Zip PF02535.22 ETO24936.1 - 0.6 9.3 3.8 0.75 9.0 3.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CNDH2_C PF16858.5 ETO24937.1 - 0.12 12.2 16.5 0.17 11.8 16.5 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Astro_capsid_p PF12226.8 ETO24937.1 - 0.28 10.3 14.7 0.39 9.8 14.7 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SlyX PF04102.12 ETO24937.1 - 0.42 11.2 5.7 1 10.0 5.7 1.7 1 0 0 1 1 1 0 SlyX SPX PF03105.19 ETO24937.1 - 0.92 9.4 18.9 1 9.2 18.2 1.4 1 1 0 1 1 1 0 SPX domain DUF4637 PF15470.6 ETO24937.1 - 2 8.1 10.9 4.6 6.9 10.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF1639 PF07797.14 ETO24938.1 - 0.093 12.7 0.1 0.35 10.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1639) YtzH PF14165.6 ETO24938.1 - 8.9 6.8 9.6 16 5.9 0.1 5.0 6 0 0 6 6 6 0 YtzH-like protein WD40 PF00400.32 ETO24939.1 - 1.3e-27 95.4 25.3 1.7e-05 25.5 0.8 7.2 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO24939.1 - 7.8e-09 35.7 0.2 0.013 15.8 0.0 5.0 4 2 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PocR PF10114.9 ETO24940.1 - 0.1 12.4 0.1 0.2 11.4 0.0 1.5 1 1 0 1 1 1 0 Sensory domain found in PocR Cation_efflux PF01545.21 ETO24941.1 - 5.7e-06 26.2 1.8 1e-05 25.4 1.8 1.4 1 0 0 1 1 1 1 Cation efflux family Sec62 PF03839.16 ETO24941.1 - 0.0014 18.2 1.9 0.0014 18.2 1.9 3.3 3 0 0 3 3 3 1 Translocation protein Sec62 Zip PF02535.22 ETO24941.1 - 0.003 16.9 3.8 0.003 16.9 3.8 2.5 2 0 0 2 2 2 1 ZIP Zinc transporter CDC45 PF02724.14 ETO24941.1 - 0.0031 15.9 3.0 0.0031 15.9 3.0 1.9 2 0 0 2 2 2 1 CDC45-like protein CAP_N PF01213.19 ETO24941.1 - 0.18 11.3 15.2 0.41 10.1 15.2 1.6 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal SelP_N PF04592.14 ETO24941.1 - 0.88 8.9 30.3 0.28 10.6 24.1 2.7 3 0 0 3 3 3 0 Selenoprotein P, N terminal region Mito_fiss_reg PF05308.11 ETO24941.1 - 6.9 6.7 22.5 0.24 11.5 14.7 2.1 2 0 0 2 2 2 0 Mitochondrial fission regulator Pkinase PF00069.25 ETO24942.1 - 3.1e-66 223.4 0.0 3.5e-66 223.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO24942.1 - 2.4e-35 122.1 0.0 2.9e-35 121.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO24942.1 - 0.00012 21.5 0.0 0.00016 21.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO24942.1 - 0.011 14.6 0.0 0.017 13.9 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase PAC2 PF09754.9 ETO24945.1 - 6.8e-07 29.5 0.0 0.025 14.6 0.0 3.0 2 1 0 2 2 2 2 PAC2 family Orthopox_F14 PF06076.12 ETO24945.1 - 0.068 13.5 1.2 2.5 8.4 0.0 2.5 2 0 0 2 2 2 0 Orthopoxvirus F14 protein HisKA_3 PF07730.13 ETO24945.1 - 0.096 13.2 0.2 0.2 12.2 0.2 1.5 1 0 0 1 1 1 0 Histidine kinase CCER1 PF15482.6 ETO24945.1 - 4.8 7.0 4.3 8.5 6.2 4.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 G-alpha PF00503.20 ETO24946.1 - 3.7e-14 52.7 1.1 4.3e-14 52.4 1.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO24946.1 - 0.012 15.1 0.1 0.013 14.9 0.1 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family AAA_21 PF13304.6 ETO24946.1 - 0.044 13.6 0.1 0.051 13.4 0.1 1.1 1 0 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 ETO24946.1 - 0.044 14.0 0.1 0.061 13.6 0.1 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ETO24946.1 - 0.05 13.4 1.9 0.071 12.9 0.8 1.9 2 1 0 2 2 2 0 P-loop containing region of AAA domain G-alpha PF00503.20 ETO24947.1 - 1.3e-54 185.8 3.5 1.3e-40 139.6 0.9 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO24947.1 - 1.5e-05 24.5 0.1 3.7e-05 23.3 0.1 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family OST-HTH PF12872.7 ETO24948.1 - 5.5e-08 32.5 1.7 0.00057 19.6 0.1 4.8 5 0 0 5 5 5 2 OST-HTH/LOTUS domain Cys_rich_KTR PF14205.6 ETO24948.1 - 0.025 14.4 0.3 0.063 13.1 0.3 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR RRM_1 PF00076.22 ETO24948.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DAGK_cat PF00781.24 ETO24949.1 - 1.1e-07 31.5 0.0 2.1e-07 30.6 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain SPAN-X PF07458.12 ETO24949.1 - 0.054 13.9 0.3 0.054 13.9 0.3 2.2 2 0 0 2 2 2 0 Sperm protein associated with nucleus, mapped to X chromosome UCH PF00443.29 ETO24950.1 - 9.7e-25 87.5 11.6 6.1e-24 84.9 11.6 2.0 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO24950.1 - 1.3e-06 28.2 13.8 2.4e-06 27.4 13.8 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase SR-25 PF10500.9 ETO24950.1 - 0.0088 15.7 16.9 0.013 15.2 16.9 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein HEPN PF05168.14 ETO24950.1 - 0.014 15.5 0.3 0.46 10.6 0.0 2.8 2 1 1 3 3 3 0 HEPN domain MAP70 PF07058.11 ETO24950.1 - 0.037 12.8 8.5 0.048 12.4 8.5 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 MRPL52 PF18699.1 ETO24950.1 - 2.8 8.2 6.8 2.6 8.3 1.4 2.7 2 0 0 2 2 2 0 Mitoribosomal protein mL52 Presenilin PF01080.17 ETO24950.1 - 6.5 5.4 8.4 8.1 5.1 8.4 1.1 1 0 0 1 1 1 0 Presenilin Abhydrolase_9_N PF15420.6 ETO24951.1 - 3.4 7.6 12.7 1 9.3 8.8 2.1 2 1 0 2 2 2 0 Alpha/beta-hydrolase family N-terminus DUF3446 PF11928.8 ETO24951.1 - 3.6 8.0 17.0 4.5 7.7 10.7 2.5 2 0 0 2 2 2 0 Early growth response N-terminal domain Ribosomal_L30_N PF08079.12 ETO24951.1 - 4.9 7.5 7.9 0.49 10.7 3.3 1.6 2 0 0 2 2 2 0 Ribosomal L30 N-terminal domain UPF0183 PF03676.14 ETO24952.1 - 4.8e-61 207.2 12.2 1.5e-28 100.2 0.0 3.7 3 1 0 3 3 3 3 Uncharacterised protein family (UPF0183) CLN3 PF02487.17 ETO24952.1 - 0.2 10.7 7.2 0.95 8.4 0.3 2.6 2 0 0 2 2 2 0 CLN3 protein DUF789 PF05623.12 ETO24952.1 - 0.29 10.8 13.0 0.18 11.5 1.3 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF789) Connexin PF00029.19 ETO24952.1 - 0.29 10.8 3.8 3.4 7.4 0.4 2.4 2 0 0 2 2 2 0 Connexin Zip PF02535.22 ETO24952.1 - 2.6 7.2 18.5 0.24 10.6 1.5 2.7 3 0 0 3 3 3 0 ZIP Zinc transporter DUF21 PF01595.20 ETO24953.1 - 4.6e-18 65.5 0.3 5.8e-18 65.2 0.3 1.1 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain SAM_MT PF04445.13 ETO24953.1 - 0.02 14.3 0.0 0.032 13.6 0.0 1.3 1 0 0 1 1 1 0 Putative SAM-dependent methyltransferase AKAP95 PF04988.12 ETO24953.1 - 0.049 13.9 1.0 0.064 13.5 1.0 1.1 1 0 0 1 1 1 0 A-kinase anchoring protein 95 (AKAP95) Band_3_cyto PF07565.13 ETO24954.1 - 0.075 12.8 0.2 0.088 12.6 0.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain EF-hand_6 PF13405.6 ETO24955.1 - 3.1e-09 36.0 3.8 0.045 13.7 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 ETO24955.1 - 5.9e-07 29.9 3.5 1.1e-05 25.8 0.9 2.7 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO24955.1 - 2.7e-06 26.5 2.5 0.15 11.6 0.2 4.0 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO24955.1 - 0.098 12.5 1.1 0.47 10.3 0.3 2.5 3 0 0 3 3 3 0 EF-hand domain pair EF-hand_9 PF14658.6 ETO24955.1 - 0.12 12.7 0.1 12 6.3 0.1 2.6 2 0 0 2 2 2 0 EF-hand domain DEP PF00610.21 ETO24956.1 - 4.3e-11 42.7 0.1 6e-11 42.2 0.1 1.2 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Peptidase_M66 PF10462.9 ETO24956.1 - 0.064 12.2 0.2 0.094 11.7 0.2 1.2 1 0 0 1 1 1 0 Peptidase M66 UME PF08064.13 ETO24956.1 - 0.15 12.0 0.2 0.24 11.3 0.2 1.3 1 0 0 1 1 1 0 UME (NUC010) domain Pkinase PF00069.25 ETO24957.1 - 0.00073 19.0 8.9 0.11 11.8 6.5 3.0 2 1 0 2 2 2 2 Protein kinase domain NCKAP5 PF15246.6 ETO24957.1 - 0.0031 17.2 11.4 0.0041 16.8 11.4 1.1 1 0 0 1 1 1 1 Nck-associated protein 5, Peripheral clock protein DUF823 PF05689.11 ETO24957.1 - 0.14 11.9 5.1 0.26 11.0 5.1 1.4 1 0 0 1 1 1 0 Salmonella repeat of unknown function (DUF823) ALMS_motif PF15309.6 ETO24957.1 - 3.1 8.3 19.2 1.2 9.6 16.6 1.6 2 0 0 2 2 2 0 ALMS motif O-antigen_lig PF13425.6 ETO24958.1 - 0.018 13.9 0.6 0.03 13.1 0.6 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Atrophin-1 PF03154.15 ETO24959.1 - 0.00089 17.7 21.2 0.00089 17.7 21.2 2.5 2 1 1 3 3 3 1 Atrophin-1 family TRP_2 PF08344.11 ETO24959.1 - 0.0047 17.1 0.4 2.7 8.3 0.0 2.5 2 0 0 2 2 2 2 Transient receptor ion channel II TFIIA PF03153.13 ETO24959.1 - 0.19 11.7 17.2 0.27 11.2 17.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit PHD PF00628.29 ETO24960.1 - 0.0073 16.2 5.9 0.062 13.2 5.9 2.3 1 1 0 1 1 1 1 PHD-finger C1_1 PF00130.22 ETO24960.1 - 0.039 13.8 0.7 0.039 13.8 0.7 2.6 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) RNA_POL_M_15KD PF02150.16 ETO24960.1 - 0.21 11.5 0.1 0.21 11.5 0.1 3.0 3 1 0 3 3 3 0 RNA polymerases M/15 Kd subunit Zip PF02535.22 ETO24960.1 - 0.22 10.7 1.1 0.34 10.1 1.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO24961.1 - 9.3 7.3 8.6 1.7 9.6 2.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF4834 PF16118.5 ETO24962.1 - 0.0058 17.6 0.4 0.58 11.2 0.0 3.4 3 0 0 3 3 3 1 Domain of unknown function (DUF4834) Mucin PF01456.17 ETO24962.1 - 0.008 16.2 0.2 0.008 16.2 0.2 2.5 3 0 0 3 3 3 1 Mucin-like glycoprotein DUF3439 PF11921.8 ETO24962.1 - 1.5 8.8 8.4 3 7.8 7.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF3439) TMCCDC2 PF15844.5 ETO24962.1 - 2.7 7.9 8.5 3.7 7.4 0.0 3.4 4 0 0 4 4 4 0 Transmembrane and coiled-coil domain-containing protein 2 40S_S4_C PF16121.5 ETO24963.1 - 1.1e-19 69.7 0.1 2.7e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 40S ribosomal protein S4 C-terminus Ribosomal_S4e PF00900.20 ETO24963.1 - 2.2e-17 62.7 0.1 2.2e-17 62.7 0.1 2.4 3 0 0 3 3 3 1 Ribosomal family S4e KOW PF00467.29 ETO24963.1 - 0.00031 20.6 3.4 0.00071 19.4 3.4 1.6 1 0 0 1 1 1 1 KOW motif NAD_binding_1 PF00175.21 ETO24963.1 - 0.023 15.3 0.1 0.43 11.2 0.2 2.1 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Saf_2TM PF18303.1 ETO24964.1 - 0.13 11.9 0.8 0.23 11.1 0.3 1.7 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Orf78 PF06024.12 ETO24964.1 - 3.3 8.1 6.9 8.7 6.7 5.9 2.3 2 1 0 2 2 2 0 Orf78 (ac78) PBP1_TM PF14812.6 ETO24965.1 - 6.3 7.2 14.4 0.69 10.3 1.2 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF5056 PF16479.5 ETO24966.1 - 0.89 9.8 0.1 0.89 9.8 0.1 3.1 2 1 1 4 4 4 0 Domain of unknown function (DUF5056) GtrA PF04138.14 ETO24967.1 - 0.00018 21.7 3.7 0.00018 21.7 3.7 2.6 2 1 0 2 2 2 1 GtrA-like protein Proteasome PF00227.26 ETO24968.1 - 9.6e-28 97.0 0.6 3.2e-27 95.3 0.6 1.7 1 1 0 1 1 1 1 Proteasome subunit SAM_1 PF00536.30 ETO24970.1 - 0.014 15.8 0.7 0.2 12.1 0.7 2.3 1 1 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO24970.1 - 0.016 15.3 0.6 3.6 7.8 0.0 2.6 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF4897 PF16238.5 ETO24972.1 - 0.78 9.6 6.9 1.1 9.0 5.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4897) CAP_GLY PF01302.25 ETO24973.1 - 5.7e-05 23.1 0.1 0.00011 22.1 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain MIS13 PF08202.11 ETO24973.1 - 0.003 16.9 0.4 0.0043 16.4 0.4 1.2 1 0 0 1 1 1 1 Mis12-Mtw1 protein family Phage_capsid PF05065.13 ETO24973.1 - 0.0081 15.5 0.1 0.012 15.0 0.1 1.2 1 0 0 1 1 1 1 Phage capsid family GAS PF13851.6 ETO24973.1 - 0.011 15.1 1.5 0.017 14.5 1.5 1.3 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4201 PF13870.6 ETO24973.1 - 0.015 15.0 0.2 0.015 15.0 0.2 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4201) DUF1515 PF07439.11 ETO24973.1 - 0.031 14.3 0.2 0.06 13.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) ABC_tran_Xtn PF12848.7 ETO24973.1 - 0.043 13.9 0.8 0.078 13.0 0.8 1.4 1 0 0 1 1 1 0 ABC transporter DivIC PF04977.15 ETO24973.1 - 0.63 9.9 6.3 0.45 10.3 3.2 2.2 1 1 1 2 2 2 0 Septum formation initiator FlxA PF14282.6 ETO24973.1 - 0.91 9.6 10.9 56 3.8 0.4 2.5 1 1 0 1 1 1 0 FlxA-like protein zf-CCCH_2 PF14608.6 ETO24974.1 - 0.0096 16.4 1.8 0.022 15.2 1.8 1.7 1 0 0 1 1 1 1 RNA-binding, Nab2-type zinc finger DDE_Tnp_IS1595 PF12762.7 ETO24975.1 - 0.0063 16.5 0.7 0.014 15.4 0.7 1.5 1 0 0 1 1 1 1 ISXO2-like transposase domain IMS PF00817.20 ETO24975.1 - 0.062 13.3 0.2 0.48 10.4 0.2 2.2 1 1 0 1 1 1 0 impB/mucB/samB family Peptidase_C14 PF00656.22 ETO24978.1 - 1.4e-11 44.8 0.4 3.4e-11 43.6 0.4 1.7 1 0 0 1 1 1 1 Caspase domain Kelch_3 PF13415.6 ETO24978.1 - 6.2e-05 23.2 0.0 0.0038 17.5 0.0 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO24978.1 - 0.00025 20.6 3.0 0.0009 18.8 0.1 3.3 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO24978.1 - 0.0006 19.7 0.7 0.12 12.4 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO24978.1 - 0.0055 16.7 0.9 0.014 15.4 0.1 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO24978.1 - 0.02 15.1 8.1 0.24 11.7 0.0 4.9 4 2 1 5 5 5 0 Kelch motif Kelch_2 PF07646.15 ETO24978.1 - 0.44 10.6 3.5 1.2 9.2 0.1 3.6 4 0 0 4 4 4 0 Kelch motif SprA-related PF12118.8 ETO24978.1 - 0.47 9.5 14.3 0.78 8.8 14.3 1.2 1 0 0 1 1 1 0 SprA-related family DUF1980 PF09323.10 ETO24978.1 - 6.4 6.7 8.6 17 5.3 8.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) Peptidase_C14 PF00656.22 ETO24979.1 - 1.8e-11 44.5 0.3 2.9e-11 43.8 0.3 1.3 1 0 0 1 1 1 1 Caspase domain DUF3007 PF11460.8 ETO24982.1 - 3.4 8.0 5.3 4.9 7.5 0.6 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3007) MFMR PF07777.11 ETO24983.1 - 0.044 14.3 1.7 0.09 13.3 1.7 1.5 1 0 0 1 1 1 0 G-box binding protein MFMR JAKMIP_CC3 PF16034.5 ETO24983.1 - 0.22 11.4 5.2 0.21 11.5 4.5 1.3 1 1 0 1 1 1 0 JAKMIP CC3 domain Phosphoprotein PF00922.17 ETO24985.1 - 0.00027 20.6 0.5 0.00029 20.5 0.5 1.2 1 0 0 1 1 1 1 Vesiculovirus phosphoprotein PBP1_TM PF14812.6 ETO24985.1 - 0.21 12.0 9.4 0.2 12.0 4.1 2.3 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal peroxidase PF00141.23 ETO24986.1 - 3e-19 69.7 0.0 3.3e-19 69.5 0.0 1.0 1 0 0 1 1 1 1 Peroxidase peroxidase PF00141.23 ETO24987.1 - 6e-10 39.2 0.0 8.9e-10 38.6 0.0 1.3 1 0 0 1 1 1 1 Peroxidase Methyltransf_9 PF08003.11 ETO24988.1 - 1.5 7.7 9.0 0.087 11.7 2.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) TRAM_LAG1_CLN8 PF03798.16 ETO24989.1 - 2.1e-10 40.6 18.8 4.4e-10 39.6 18.8 1.5 1 0 0 1 1 1 1 TLC domain DUF3246 PF11596.8 ETO24990.1 - 0.018 14.5 0.6 0.018 14.5 0.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF3246) CAP_GLY PF01302.25 ETO24991.1 - 6.7e-32 109.3 3.8 2.9e-16 59.2 0.2 2.1 2 0 0 2 2 2 2 CAP-Gly domain DUF1126 PF06565.12 ETO24991.1 - 0.16 11.8 0.1 0.36 10.7 0.1 1.5 1 0 0 1 1 1 0 DUF1126 PH-like domain MCD_N PF17408.2 ETO24992.1 - 0.004 17.3 0.2 0.74 10.0 0.0 2.4 2 0 0 2 2 2 2 Malonyl-CoA decarboxylase N-terminal domain AAA PF00004.29 ETO24992.1 - 0.015 15.7 0.0 0.025 15.0 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) UPF0242 PF06785.11 ETO24996.1 - 0.0012 19.0 4.3 0.0013 18.8 4.3 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF4795 PF16043.5 ETO24996.1 - 0.0014 18.2 1.7 0.0015 18.2 1.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4795) T3SSipB PF16535.5 ETO24996.1 - 0.002 18.6 5.2 0.0025 18.3 5.2 1.1 1 0 0 1 1 1 1 Type III cell invasion protein SipB IFT57 PF10498.9 ETO24996.1 - 0.0028 16.7 4.6 0.0038 16.3 4.6 1.1 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 Filament PF00038.21 ETO24996.1 - 0.0029 17.3 3.2 0.0033 17.1 3.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein DLP_helical PF18709.1 ETO24996.1 - 0.0066 15.7 0.3 0.0068 15.7 0.3 1.1 1 0 0 1 1 1 1 Dynamin-like helical domain CENP-F_leu_zip PF10473.9 ETO24996.1 - 0.0078 16.2 5.8 0.011 15.8 5.8 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO24996.1 - 0.0078 15.1 4.7 0.0094 14.9 4.7 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein EzrA PF06160.12 ETO24996.1 - 0.0085 14.3 4.6 0.0095 14.2 4.6 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA HMMR_N PF15905.5 ETO24996.1 - 0.0093 15.5 5.1 0.012 15.1 5.1 1.1 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal DUF2120 PF09893.9 ETO24996.1 - 0.02 15.0 0.2 0.028 14.5 0.2 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2120) OmpH PF03938.14 ETO24996.1 - 0.026 14.9 7.0 0.036 14.4 7.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) Vps5 PF09325.10 ETO24996.1 - 0.026 14.1 4.9 0.035 13.7 4.9 1.1 1 0 0 1 1 1 0 Vps5 C terminal like CdvA PF18822.1 ETO24996.1 - 0.04 13.7 3.3 0.062 13.1 3.3 1.2 1 0 0 1 1 1 0 CdvA-like coiled-coil domain Exonuc_VII_L PF02601.15 ETO24996.1 - 0.049 13.2 2.7 0.045 13.3 2.7 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit HemX PF04375.14 ETO24996.1 - 0.062 12.6 8.0 0.075 12.3 8.0 1.1 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase FPP PF05911.11 ETO24996.1 - 0.066 11.4 7.3 0.084 11.1 7.3 1.1 1 0 0 1 1 1 0 Filament-like plant protein, long coiled-coil COG6 PF06419.11 ETO24996.1 - 0.1 10.8 5.9 0.12 10.5 5.9 1.0 1 0 0 1 1 1 0 Conserved oligomeric complex COG6 COG2 PF06148.11 ETO24996.1 - 0.16 12.0 3.5 0.47 10.5 3.1 1.8 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 FapA PF03961.13 ETO24996.1 - 0.2 10.2 2.8 0.22 10.1 2.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Prominin PF05478.11 ETO24996.1 - 0.23 9.4 5.0 0.26 9.2 5.0 1.0 1 0 0 1 1 1 0 Prominin MCU PF04678.13 ETO24996.1 - 0.23 11.5 2.4 0.3 11.2 2.4 1.2 1 0 0 1 1 1 0 Mitochondrial calcium uniporter TMPIT PF07851.13 ETO24996.1 - 0.24 10.6 5.7 0.34 10.1 5.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein Phage_GP20 PF06810.11 ETO24996.1 - 0.27 11.0 6.9 0.28 11.0 6.2 1.4 1 1 0 1 1 1 0 Phage minor structural protein GP20 Rota_NSP3 PF01665.16 ETO24996.1 - 0.3 10.2 3.7 0.34 10.0 1.6 1.8 1 1 1 2 2 2 0 Rotavirus non-structural protein NSP3 ACCA PF03255.14 ETO24996.1 - 0.33 10.8 3.6 0.49 10.3 3.6 1.2 1 0 0 1 1 1 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit XhlA PF10779.9 ETO24996.1 - 0.5 10.6 3.7 0.77 10.0 3.7 1.3 1 0 0 1 1 1 0 Haemolysin XhlA Nup54 PF13874.6 ETO24996.1 - 0.65 10.1 11.2 0.14 12.3 6.5 1.8 1 1 1 2 2 2 0 Nucleoporin complex subunit 54 TMF_TATA_bd PF12325.8 ETO24996.1 - 0.82 9.9 9.0 3.2 8.0 9.2 1.7 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding THOC7 PF05615.13 ETO24996.1 - 0.98 9.7 8.4 1.3 9.3 8.4 1.1 1 0 0 1 1 1 0 Tho complex subunit 7 LPP PF04728.13 ETO24996.1 - 5.4 7.5 11.0 0.48 10.9 1.7 2.3 1 1 1 2 2 2 0 Lipoprotein leucine-zipper Alba PF01918.21 ETO24997.1 - 2.9e-12 46.2 0.1 4.6e-12 45.6 0.1 1.4 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 ETO24997.1 - 0.011 15.7 0.4 0.016 15.1 0.4 1.3 1 0 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P Actin PF00022.19 ETO24998.1 - 0.048 12.3 0.8 0.061 11.9 0.8 1.0 1 0 0 1 1 1 0 Actin TrmO_C PF18389.1 ETO24999.1 - 0.072 13.2 0.1 0.15 12.1 0.1 1.5 1 0 0 1 1 1 0 TrmO C-terminal domain WSD PF15613.6 ETO25000.1 - 3.5 8.2 6.3 6.7 7.2 6.3 1.7 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif Kelch_1 PF01344.25 ETO25001.1 - 1.2e-11 44.0 0.3 0.058 13.0 0.2 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO25001.1 - 0.0011 18.9 0.8 51 4.0 0.0 5.3 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO25001.1 - 0.0062 16.8 4.9 23 5.4 0.0 5.8 6 0 0 6 6 6 1 Kelch motif DUF1465 PF07323.12 ETO25003.1 - 0.14 12.0 1.2 0.4 10.5 1.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) Transglut_i_TM PF14400.6 ETO25003.1 - 0.42 10.7 3.3 0.56 10.3 0.3 2.6 2 0 0 2 2 2 0 Inactive transglutaminase fused to 7 transmembrane helices Slx4 PF09494.10 ETO25004.1 - 1.4e-07 31.3 0.1 2.3e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Slx4 endonuclease Nup96 PF12110.8 ETO25004.1 - 0.032 13.3 0.5 0.042 13.0 0.5 1.3 1 0 0 1 1 1 0 Nuclear protein 96 TPR_12 PF13424.6 ETO25005.1 - 6.2e-05 23.2 1.2 0.022 15.0 0.5 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO25005.1 - 0.00068 19.5 2.4 5.5 7.2 0.1 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat Prefoldin PF02996.17 ETO25005.1 - 0.0052 16.7 0.4 0.042 13.8 0.1 2.3 1 1 1 2 2 2 1 Prefoldin subunit TPR_1 PF00515.28 ETO25005.1 - 0.027 14.3 7.8 1.5 8.7 0.1 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat Methyltransf_12 PF08242.12 ETO25006.1 - 0.0024 18.6 0.5 0.0031 18.2 0.5 1.2 1 0 0 1 1 1 1 Methyltransferase domain Anoct_dimer PF16178.5 ETO25006.1 - 0.013 15.3 1.7 0.014 15.1 1.7 1.0 1 0 0 1 1 1 0 Dimerisation domain of Ca+-activated chloride-channel, anoctamin DUF2718 PF10918.8 ETO25006.1 - 0.033 14.7 0.6 0.037 14.5 0.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2718) DUF383 PF04063.14 ETO25007.1 - 7.7e-39 133.3 3.4 8.5e-38 129.9 1.7 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF383) Arm PF00514.23 ETO25007.1 - 0.057 13.5 0.1 0.19 11.9 0.1 2.0 1 0 0 1 1 1 0 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ETO25007.1 - 0.072 13.4 0.1 91 3.7 0.0 3.8 3 0 0 3 3 3 0 HEAT repeat IHABP4_N PF16174.5 ETO25008.1 - 0.14 12.7 3.8 3 8.4 0.0 2.2 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal Shisa PF13908.6 ETO25008.1 - 0.86 9.8 4.3 1.4 9.1 4.3 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Mucin PF01456.17 ETO25008.1 - 1.8 8.6 16.4 5.6 6.9 15.6 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein Dicty_REP PF05086.12 ETO25008.1 - 3.3 5.6 13.5 3.6 5.4 13.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AAA_26 PF13500.6 ETO25009.1 - 0.066 13.0 0.1 13 5.5 0.0 2.2 2 0 0 2 2 2 0 AAA domain DNA_pol_B PF00136.21 ETO25010.1 - 1.5e-26 93.2 0.0 2.6e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 DNA polymerase family B DNA_pol_B_exo1 PF03104.19 ETO25010.1 - 3.6e-14 52.7 0.1 6.7e-14 51.8 0.1 1.4 1 0 0 1 1 1 1 DNA polymerase family B, exonuclease domain DNA_pol_B_2 PF03175.13 ETO25010.1 - 0.015 14.1 0.3 0.036 12.9 0.3 1.6 1 0 0 1 1 1 0 DNA polymerase type B, organellar and viral LMBR1 PF04791.16 ETO25013.1 - 9.9e-44 150.1 26.1 2.2e-23 83.0 2.3 3.6 2 1 1 3 3 3 2 LMBR1-like membrane protein Nop14 PF04147.12 ETO25013.1 - 0.0059 14.9 23.4 0.0088 14.3 23.4 1.3 1 0 0 1 1 1 1 Nop14-like family Myc_N PF01056.18 ETO25013.1 - 0.015 15.2 11.3 0.033 14.1 2.1 2.2 2 0 0 2 2 2 0 Myc amino-terminal region DUF1152 PF06626.12 ETO25014.1 - 1.4e-11 44.2 0.1 1.4e-07 31.0 0.0 2.3 2 0 0 2 2 2 2 Protein of unknown function (DUF1152) Rad51 PF08423.11 ETO25015.1 - 5.3e-27 94.7 0.1 1e-24 87.2 0.1 2.1 2 0 0 2 2 2 2 Rad51 AAA_25 PF13481.6 ETO25015.1 - 3.4e-09 36.5 0.0 2.4e-07 30.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain ATPase PF06745.13 ETO25015.1 - 3.5e-09 36.4 0.8 1.5e-08 34.3 0.4 2.2 1 1 1 2 2 2 1 KaiC RecA PF00154.21 ETO25015.1 - 3.1e-05 23.6 0.0 0.1 12.1 0.0 3.1 3 0 0 3 3 3 1 recA bacterial DNA recombination protein AAA_24 PF13479.6 ETO25015.1 - 0.00014 21.7 2.6 0.00043 20.1 2.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO25015.1 - 0.00099 19.4 0.2 0.0032 17.7 0.0 1.9 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO25015.1 - 0.006 17.0 0.0 0.013 15.9 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain DUF2075 PF09848.9 ETO25015.1 - 0.0093 15.2 2.4 0.05 12.8 0.1 2.6 1 1 2 3 3 3 1 Uncharacterized conserved protein (DUF2075) Polysacc_synt_2 PF02719.15 ETO25015.1 - 0.019 14.1 0.2 0.037 13.2 0.2 1.5 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein DUF1666 PF07891.12 ETO25015.1 - 0.036 13.7 2.8 0.079 12.6 2.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1666) DnaB_C PF03796.15 ETO25015.1 - 0.052 12.9 0.2 0.33 10.3 0.1 2.4 1 1 0 1 1 1 0 DnaB-like helicase C terminal domain NACHT PF05729.12 ETO25015.1 - 0.091 12.7 0.2 0.28 11.1 0.1 1.8 1 1 0 1 1 1 0 NACHT domain AAA PF00004.29 ETO25015.1 - 0.11 13.0 1.2 1.3 9.5 0.5 2.5 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO25015.1 - 0.34 10.9 2.2 0.55 10.2 0.2 2.4 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) DUF3439 PF11921.8 ETO25015.1 - 1.9 8.5 4.3 3.1 7.8 0.2 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO25015.1 - 7.2 6.6 10.3 12 5.9 10.3 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Sulfotransfer_3 PF13469.6 ETO25016.1 - 0.038 14.4 0.1 0.15 12.4 0.1 2.2 1 1 0 1 1 1 0 Sulfotransferase family Kelch_6 PF13964.6 ETO25017.1 - 8.3e-05 22.7 2.2 0.16 12.3 0.3 3.1 3 0 0 3 3 3 2 Kelch motif Sun2_CC2 PF18580.1 ETO25017.1 - 0.096 12.9 0.0 0.18 12.1 0.0 1.4 1 0 0 1 1 1 0 SUN2 coiled coil domain 2 Kelch_1 PF01344.25 ETO25017.1 - 0.14 11.8 2.6 9 6.0 0.1 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO25017.1 - 0.66 10.1 6.5 4.9 7.3 0.1 4.1 4 1 0 4 4 4 0 Kelch motif CRIM PF16978.5 ETO25018.1 - 5.4e-08 33.1 3.7 6e-07 29.7 0.0 3.0 2 1 0 3 3 3 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain DSPc PF00782.20 ETO25019.1 - 6.8e-22 77.7 0.1 7.9e-22 77.5 0.1 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO25019.1 - 0.085 12.4 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein-tyrosine phosphatase Vpu PF00558.19 ETO25020.1 - 0.05 13.4 0.0 0.099 12.4 0.0 1.4 1 0 0 1 1 1 0 Vpu protein DUF5385 PF17359.2 ETO25021.1 - 0.22 11.1 5.8 0.4 10.2 5.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5385) COG6 PF06419.11 ETO25023.1 - 6.1e-23 80.9 18.9 1.4e-22 79.7 18.9 1.5 1 1 0 1 1 1 1 Conserved oligomeric complex COG6 EcoR124_C PF12008.8 ETO25023.1 - 0.0023 17.7 7.8 0.0023 17.7 7.8 2.1 1 1 0 2 2 2 1 Type I restriction and modification enzyme - subunit R C terminal Dak2 PF02734.17 ETO25023.1 - 0.0024 17.8 0.9 0.004 17.1 0.8 1.4 1 1 0 1 1 1 1 DAK2 domain Mce4_CUP1 PF11887.8 ETO25023.1 - 0.092 12.2 0.9 0.16 11.4 0.5 1.6 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative DUF948 PF06103.11 ETO25023.1 - 0.097 12.9 1.3 0.29 11.4 1.3 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Sec34 PF04136.15 ETO25023.1 - 0.11 12.4 13.7 0.042 13.7 9.0 2.5 2 1 0 2 2 2 0 Sec34-like family Laminin_II PF06009.12 ETO25023.1 - 0.13 12.2 4.8 0.4 10.7 4.8 1.9 1 0 0 1 1 1 0 Laminin Domain II LMBR1 PF04791.16 ETO25023.1 - 0.31 9.9 7.2 0.44 9.4 7.2 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein PDDEXK_6 PF04720.12 ETO25023.1 - 2.9 7.8 10.1 2.3 8.1 8.3 1.8 1 1 1 2 2 2 0 PDDEXK-like family of unknown function Sec20 PF03908.13 ETO25023.1 - 4.4 7.3 7.7 3.8 7.5 3.3 2.5 2 0 0 2 2 2 0 Sec20 DASH_Dad3 PF08656.10 ETO25023.1 - 4.7 7.4 7.0 0.74 9.9 1.5 2.3 2 1 0 2 2 2 0 DASH complex subunit Dad3 APG6_N PF17675.1 ETO25023.1 - 4.7 7.7 16.2 5.2 7.6 15.0 1.9 1 1 0 1 1 1 0 Apg6 coiled-coil region XRN_N PF03159.18 ETO25024.1 - 3.1e-37 128.3 0.3 9.1e-37 126.8 0.0 1.8 2 0 0 2 2 2 1 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 ETO25024.1 - 5.6e-11 42.1 0.9 5.6e-11 42.1 0.9 2.0 2 0 0 2 2 2 1 Xrn1 helical domain Nop25 PF09805.9 ETO25024.1 - 0.015 15.7 0.5 0.028 14.9 0.5 1.4 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Secretin_N_2 PF07655.13 ETO25024.1 - 0.045 14.3 8.0 0.32 11.6 7.5 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain Presenilin PF01080.17 ETO25024.1 - 0.23 10.2 0.0 0.33 9.7 0.0 1.3 1 0 0 1 1 1 0 Presenilin RabGAP-TBC PF00566.18 ETO25025.1 - 3.9e-10 39.8 0.7 4.3e-08 33.1 0.7 2.6 1 1 0 1 1 1 1 Rab-GTPase-TBC domain TLD PF07534.16 ETO25025.1 - 0.002 18.4 0.0 0.0055 16.9 0.0 1.8 1 0 0 1 1 1 1 TLD DUF4476 PF14771.6 ETO25025.1 - 0.024 14.9 0.5 0.92 9.9 0.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4476) CDC45 PF02724.14 ETO25026.1 - 0.2 9.9 16.7 0.22 9.8 16.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO25026.1 - 0.67 8.0 21.5 1.3 7.0 21.5 1.4 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO25026.1 - 3.4 5.7 23.9 4.5 5.4 23.9 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3530 PF12048.8 ETO25026.1 - 8.5 5.7 11.6 0.78 9.1 6.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) CRAL_TRIO PF00650.20 ETO25027.1 - 1.8e-14 53.8 0.8 1.5e-13 50.8 0.1 2.6 3 1 0 3 3 3 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ETO25027.1 - 0.01 16.0 2.0 0.018 15.2 1.6 1.7 1 1 0 1 1 1 0 Divergent CRAL/TRIO domain FSA_C PF10479.9 ETO25027.1 - 2 6.5 21.3 2.9 5.9 21.3 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus RR_TM4-6 PF06459.12 ETO25029.1 - 0.17 11.7 3.8 0.26 11.1 3.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 ETO25029.1 - 0.18 8.9 19.5 0.23 8.6 19.5 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Lin-8 PF03353.15 ETO25029.1 - 0.93 9.0 14.5 2.1 7.8 14.5 1.6 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist NST1 PF13945.6 ETO25029.1 - 1.2 9.2 13.6 0.62 10.1 11.3 1.6 1 1 1 2 2 2 0 Salt tolerance down-regulator MAP65_ASE1 PF03999.12 ETO25029.1 - 1.7 7.3 19.7 0.74 8.4 17.8 1.3 1 1 0 1 1 1 0 Microtubule associated protein (MAP65/ASE1 family) Menin PF05053.13 ETO25029.1 - 2 6.7 9.1 2.6 6.3 9.1 1.1 1 0 0 1 1 1 0 Menin TFIIA PF03153.13 ETO25029.1 - 3.2 7.6 24.7 2.5 8.0 23.0 1.4 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 ETO25030.1 - 2.7e-06 28.0 14.0 0.00019 22.1 0.2 5.2 5 0 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25030.1 - 5.5e-05 23.4 1.0 0.025 14.9 0.1 2.9 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain RNA_polI_A34 PF08208.11 ETO25030.1 - 0.25 11.4 9.1 0.52 10.4 9.1 1.5 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Ge1_WD40 PF16529.5 ETO25030.1 - 0.54 9.2 7.1 0.76 8.7 0.3 2.7 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Connexin PF00029.19 ETO25030.1 - 0.8 9.4 7.1 0.82 9.4 1.9 2.7 3 0 0 3 3 3 0 Connexin EIIBC-GUT_N PF03612.14 ETO25030.1 - 1.2 8.9 4.0 12 5.6 2.3 2.6 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus PH PF00169.29 ETO25031.1 - 1.4e-05 25.6 6.3 0.16 12.5 0.1 4.2 3 2 1 4 4 4 2 PH domain TERB2 PF15101.6 ETO25031.1 - 0.055 13.5 0.1 0.055 13.5 0.1 2.1 1 1 1 2 2 2 0 Telomere-associated protein TERB2 Exo_endo_phos_2 PF14529.6 ETO25032.1 - 2.6e-05 24.0 2.7 3.4e-05 23.7 0.1 2.3 2 1 1 3 3 3 1 Endonuclease-reverse transcriptase PH PF00169.29 ETO25034.1 - 0.0005 20.5 0.3 0.0005 20.5 0.3 2.3 3 0 0 3 3 3 1 PH domain Phage_gp53 PF11246.8 ETO25035.1 - 0.09 12.5 0.0 0.11 12.1 0.0 1.1 1 0 0 1 1 1 0 Base plate wedge protein 53 GST_N_3 PF13417.6 ETO25037.1 - 2.3e-17 63.1 0.0 7.1e-17 61.6 0.0 1.8 2 0 0 2 2 2 1 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETO25037.1 - 4.9e-12 46.0 0.0 1.1e-11 44.9 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_N PF02798.20 ETO25037.1 - 1e-11 45.0 0.0 2.3e-11 43.9 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_2 PF13410.6 ETO25037.1 - 3e-05 23.9 0.0 5.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_5 PF16865.5 ETO25037.1 - 0.00098 19.7 0.1 0.0026 18.3 0.1 1.9 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_4 PF17172.4 ETO25037.1 - 0.034 14.9 0.0 0.08 13.7 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase N-terminal domain GST_C_3 PF14497.6 ETO25037.1 - 0.044 14.0 0.0 0.1 12.8 0.0 1.7 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain PspB PF06667.12 ETO25038.1 - 0.045 13.8 0.8 0.058 13.5 0.8 1.2 1 0 0 1 1 1 0 Phage shock protein B ANAPC15 PF15243.6 ETO25038.1 - 0.15 12.5 7.1 0.17 12.3 7.1 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 TLD PF07534.16 ETO25039.1 - 2.4e-08 34.3 1.7 3.1e-07 30.7 0.0 2.7 3 0 0 3 3 3 1 TLD Apis_Csd PF11671.8 ETO25039.1 - 0.49 10.4 15.5 0.067 13.2 2.8 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein NDK PF00334.19 ETO25040.1 - 6.1e-85 282.1 0.0 1.5e-42 144.8 0.0 2.0 1 1 1 2 2 2 2 Nucleoside diphosphate kinase LMP PF04778.12 ETO25040.1 - 0.033 14.1 0.4 6.3 6.7 0.0 2.2 2 0 0 2 2 2 0 LMP repeated region Arg_repressor PF01316.21 ETO25040.1 - 0.052 13.3 0.3 0.99 9.2 0.0 2.3 2 0 0 2 2 2 0 Arginine repressor, DNA binding domain Pkinase PF00069.25 ETO25041.1 - 1.9e-42 145.4 0.0 3.3e-42 144.7 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25041.1 - 7.6e-19 68.0 0.0 1.3e-18 67.3 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO25041.1 - 0.0084 14.9 0.0 0.011 14.5 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase MFS_1 PF07690.16 ETO25042.1 - 1.2e-27 96.8 26.5 1e-18 67.4 18.6 2.2 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO25042.1 - 2.8e-05 23.2 7.7 2.8e-05 23.2 7.7 3.0 1 1 2 4 4 4 1 Sugar (and other) transporter MFS_3 PF05977.13 ETO25042.1 - 0.00013 20.6 10.0 0.00017 20.1 10.0 1.2 1 0 0 1 1 1 1 Transmembrane secretion effector MFS_1_like PF12832.7 ETO25042.1 - 0.00067 18.6 3.9 0.0024 16.8 1.2 2.2 2 0 0 2 2 2 1 MFS_1 like family LacY_symp PF01306.19 ETO25042.1 - 0.00082 18.3 4.1 0.0013 17.6 2.4 1.9 2 0 0 2 2 2 1 LacY proton/sugar symporter OATP PF03137.20 ETO25042.1 - 0.0038 15.6 0.1 0.0038 15.6 0.1 2.8 2 2 1 4 4 4 1 Organic Anion Transporter Polypeptide (OATP) family Multi_Drug_Res PF00893.19 ETO25042.1 - 0.027 15.1 0.3 0.11 13.2 0.3 2.0 1 0 0 1 1 1 0 Small Multidrug Resistance protein Methyltransf_21 PF05050.12 ETO25043.1 - 4.8e-05 23.5 2.7 9.2e-05 22.5 2.7 1.5 1 0 0 1 1 1 1 Methyltransferase FkbM domain Rxt3 PF08642.10 ETO25043.1 - 0.00075 20.3 2.6 0.078 13.7 0.3 2.3 2 0 0 2 2 2 2 Histone deacetylation protein Rxt3 DUF1837 PF08878.11 ETO25043.1 - 0.011 15.5 7.1 0.011 15.5 7.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF1837) DUF3464 PF11947.8 ETO25043.1 - 1.3 8.7 8.2 0.68 9.7 1.0 2.2 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Cupin_4 PF08007.12 ETO25044.1 - 1.1e-08 34.9 4.8 1.3e-05 24.8 0.0 3.9 4 0 0 4 4 4 3 Cupin superfamily protein GlcNAc PF11397.8 ETO25045.1 - 4.7e-16 59.2 0.3 9.8e-13 48.3 0.0 2.3 2 0 0 2 2 2 2 Glycosyltransferase (GlcNAc) DUF1068 PF06364.12 ETO25046.1 - 2.9 7.7 8.9 0.52 10.2 5.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1068) bPH_3 PF14470.6 ETO25047.1 - 0.032 14.6 1.3 0.95 9.9 0.1 2.3 1 1 1 2 2 2 0 Bacterial PH domain Arm PF00514.23 ETO25048.1 - 1.6e-05 24.8 0.1 0.052 13.6 0.1 3.5 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat Ank_4 PF13637.6 ETO25049.1 - 2.7e-09 37.4 0.3 2.6e-06 27.8 0.0 2.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO25049.1 - 2.5e-07 31.2 0.3 4.9e-07 30.2 0.3 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO25049.1 - 3e-05 24.2 0.0 0.00013 22.2 0.0 2.0 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO25049.1 - 0.0013 19.1 0.2 0.61 10.8 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeat Lipoprotein_3 PF00938.17 ETO25049.1 - 0.014 15.5 0.0 0.038 14.2 0.0 1.7 1 0 0 1 1 1 0 Lipoprotein AhpC-TSA PF00578.21 ETO25049.1 - 0.016 15.1 0.0 0.024 14.5 0.0 1.2 1 0 0 1 1 1 0 AhpC/TSA family Ank PF00023.30 ETO25049.1 - 0.079 13.4 0.1 8.6 7.0 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeat DUF3447 PF11929.8 ETO25049.1 - 0.49 10.4 8.2 0.16 12.0 1.5 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF3447) SOR_SNZ PF01680.17 ETO25050.1 - 0.0014 18.4 4.2 0.0028 17.5 3.6 1.6 1 1 0 1 1 1 1 SOR/SNZ family DUF1129 PF06570.11 ETO25050.1 - 0.0065 16.0 0.1 0.016 14.7 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) UPF0242 PF06785.11 ETO25050.1 - 0.02 15.0 0.1 0.043 13.9 0.1 1.6 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus HrpB7 PF09486.10 ETO25050.1 - 0.02 15.3 2.5 0.032 14.6 2.5 1.3 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) SesA PF17107.5 ETO25050.1 - 0.04 14.1 1.4 0.075 13.2 1.1 1.6 1 1 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases YkyA PF10368.9 ETO25050.1 - 0.044 13.5 2.9 0.058 13.1 1.4 1.9 1 1 0 1 1 1 0 Putative cell-wall binding lipoprotein ISG65-75 PF11727.8 ETO25050.1 - 0.044 13.0 8.0 0.23 10.7 1.8 2.2 1 1 1 2 2 2 0 Invariant surface glycoprotein PhageMin_Tail PF10145.9 ETO25050.1 - 0.044 13.6 4.0 0.31 10.9 4.0 2.2 1 1 0 1 1 1 0 Phage-related minor tail protein Goodbye PF17109.5 ETO25050.1 - 0.075 13.5 2.6 0.33 11.4 0.2 2.6 2 1 1 3 3 3 0 fungal STAND N-terminal Goodbye domain Rx_N PF18052.1 ETO25050.1 - 0.087 13.1 4.6 0.22 11.8 0.7 2.5 1 1 2 3 3 3 0 Rx N-terminal domain FlaC_arch PF05377.11 ETO25050.1 - 0.12 12.8 0.6 0.12 12.8 0.6 3.7 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Alanine_zipper PF11839.8 ETO25050.1 - 0.17 12.3 4.7 0.087 13.2 1.0 2.4 2 0 0 2 2 2 0 Alanine-zipper, major outer membrane lipoprotein HemX PF04375.14 ETO25050.1 - 0.21 10.9 5.4 0.88 8.8 0.3 2.1 1 1 1 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase DUF745 PF05335.13 ETO25050.1 - 0.25 11.0 6.5 0.73 9.5 5.8 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF745) Fib_alpha PF08702.10 ETO25050.1 - 0.33 11.1 3.2 0.8 9.9 0.9 2.3 1 1 0 2 2 2 0 Fibrinogen alpha/beta chain family DASH_Duo1 PF08651.10 ETO25050.1 - 0.36 10.6 1.7 1.8 8.4 0.1 2.8 3 1 1 4 4 4 0 DASH complex subunit Duo1 DUF948 PF06103.11 ETO25050.1 - 0.43 10.9 23.8 2.9e+02 1.8 20.8 4.0 2 1 0 2 2 1 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 ETO25050.1 - 0.54 10.0 19.2 0.61 9.9 8.8 2.4 1 1 1 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain ETRAMP PF09716.10 ETO25050.1 - 0.92 9.6 4.0 1.3 9.1 0.0 2.7 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Seryl_tRNA_N PF02403.22 ETO25050.1 - 2 8.7 4.8 3.2 8.0 0.7 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Laminin_II PF06009.12 ETO25050.1 - 7.5 6.6 12.9 1.9 8.5 0.9 2.8 2 1 1 3 3 2 0 Laminin Domain II Myosin_TH1 PF06017.13 ETO25051.1 - 0.0027 17.4 1.9 0.0037 17.0 1.9 1.2 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Sterile PF03015.19 ETO25051.1 - 0.0055 16.9 5.0 0.0098 16.1 4.6 1.6 1 1 0 1 1 1 1 Male sterility protein DUF4834 PF16118.5 ETO25051.1 - 0.033 15.2 3.4 0.057 14.4 3.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) YlqD PF11068.8 ETO25051.1 - 0.31 11.4 12.6 0.17 12.3 10.4 1.6 2 0 0 2 2 2 0 YlqD protein Peptidase_S49_N PF08496.10 ETO25051.1 - 0.43 10.6 6.4 0.083 13.0 3.3 1.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal O-ag_pol_Wzy PF14296.6 ETO25052.1 - 0.0016 17.2 7.2 0.0016 17.2 7.2 1.1 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy EMC3_TMCO1 PF01956.16 ETO25056.1 - 0.005 16.6 2.2 0.12 12.1 0.0 3.7 3 1 0 3 3 3 1 Integral membrane protein EMC3/TMCO1-like KIAA1430 PF13879.6 ETO25057.1 - 2.6e-08 34.6 12.1 2.6e-08 34.6 12.1 3.0 2 1 1 3 3 3 1 KIAA1430 homologue PspB PF06667.12 ETO25057.1 - 0.024 14.7 3.3 0.2 11.8 0.1 2.6 2 0 0 2 2 2 0 Phage shock protein B PTR2 PF00854.21 ETO25058.1 - 3.8e-65 220.2 21.8 1.2e-56 192.3 18.4 3.5 2 1 0 2 2 2 2 POT family Glyco_hydro_47 PF01532.20 ETO25059.1 - 1.9e-23 83.1 0.1 2.8e-23 82.6 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Nop14 PF04147.12 ETO25061.1 - 0.59 8.3 18.2 0.73 8.0 18.2 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 ETO25061.1 - 3.7 6.2 10.5 5 5.8 10.5 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein LAP1C PF05609.12 ETO25063.1 - 3.5 6.6 25.1 3.9 6.5 25.1 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) BTB_2 PF02214.22 ETO25064.1 - 2.9e-20 72.4 0.1 5.4e-20 71.5 0.1 1.4 1 0 0 1 1 1 1 BTB/POZ domain BTB_3 PF16017.5 ETO25064.1 - 0.073 13.2 0.0 0.12 12.5 0.0 1.5 1 0 0 1 1 1 0 BTB/POZ domain BTB PF00651.31 ETO25064.1 - 0.077 13.2 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain Smg8_Smg9 PF10220.9 ETO25065.1 - 0.0018 16.7 0.6 0.0018 16.7 0.6 1.3 2 0 0 2 2 2 1 Smg8_Smg9 MMR_HSR1 PF01926.23 ETO25065.1 - 0.061 13.4 0.3 0.12 12.4 0.3 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase SOG2 PF10428.9 ETO25066.1 - 0.029 13.6 12.0 0.035 13.3 12.0 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Utp14 PF04615.13 ETO25066.1 - 0.6 8.6 17.1 0.67 8.5 17.1 1.1 1 0 0 1 1 1 0 Utp14 protein NPR3 PF03666.13 ETO25066.1 - 1.8 7.2 16.4 4.1 6.1 16.4 1.6 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RIFIN PF02009.16 ETO25066.1 - 4.5 7.1 11.9 7.7 6.3 11.9 1.6 1 0 0 1 1 1 0 Rifin PRP38_assoc PF12871.7 ETO25067.1 - 0.00032 21.3 23.6 0.00032 21.3 23.6 2.5 2 0 0 2 2 2 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Auts2 PF15336.6 ETO25067.1 - 0.64 10.1 11.1 0.14 12.2 6.0 2.2 2 0 0 2 2 2 0 Autism susceptibility gene 2 protein eIF3_N PF09440.10 ETO25070.1 - 2.4e-15 57.2 16.3 3.9e-08 33.8 11.8 3.3 2 1 0 2 2 2 2 eIF3 subunit 6 N terminal domain PCI PF01399.27 ETO25071.1 - 1.3e-09 38.5 0.6 2.3e-09 37.7 0.6 1.4 1 0 0 1 1 1 1 PCI domain ThrE PF06738.12 ETO25071.1 - 0.17 11.2 1.2 0.2 11.0 0.2 1.6 2 1 0 2 2 2 0 Putative threonine/serine exporter SBF2 PF12335.8 ETO25072.1 - 0.0073 15.9 2.4 0.0073 15.9 2.4 1.7 1 1 1 2 2 2 1 Myotubularin protein PAC1 PF16094.5 ETO25073.1 - 0.077 12.2 4.0 0.14 11.3 4.0 1.4 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 NOA36 PF06524.12 ETO25073.1 - 0.35 10.2 13.3 0.65 9.3 13.3 1.4 1 0 0 1 1 1 0 NOA36 protein PI3K_1B_p101 PF10486.9 ETO25073.1 - 8.3 4.0 14.5 14 3.3 14.5 1.3 1 1 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Aldo_ket_red PF00248.21 ETO25074.1 - 1.6e-28 99.7 0.0 3.6e-28 98.6 0.0 1.5 1 1 0 1 1 1 1 Aldo/keto reductase family Bacillus_HBL PF05791.11 ETO25074.1 - 0.035 13.9 0.1 0.068 13.0 0.1 1.4 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) WD40 PF00400.32 ETO25076.1 - 6e-06 26.9 6.5 1.4e-05 25.8 2.0 2.8 2 2 0 2 2 2 1 WD domain, G-beta repeat 2OG-FeII_Oxy_3 PF13640.6 ETO25077.1 - 1.2e-13 51.8 0.5 4.6e-12 46.7 0.5 2.6 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily ShK PF01549.24 ETO25077.1 - 1e-12 48.3 27.5 3e-08 34.1 10.8 3.4 4 0 0 4 4 4 2 ShK domain-like Mucin PF01456.17 ETO25077.1 - 0.0074 16.3 3.2 0.011 15.8 3.2 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein F_actin_bind PF08919.10 ETO25077.1 - 0.071 13.2 0.1 0.16 12.1 0.1 1.5 1 0 0 1 1 1 0 F-actin binding F-box-like PF12937.7 ETO25079.1 - 0.0051 16.7 1.4 0.0083 16.0 0.3 2.0 2 0 0 2 2 2 1 F-box-like Ctr PF04145.15 ETO25079.1 - 0.0074 16.9 0.0 0.015 15.9 0.0 1.6 1 0 0 1 1 1 1 Ctr copper transporter family CHASE9 PF17153.4 ETO25079.1 - 0.081 13.1 2.3 0.15 12.2 0.5 2.4 2 0 0 2 2 2 0 Periplasmic sensor domain, extracellular DUF5617 PF18493.1 ETO25079.1 - 2.3 8.4 11.2 0.79 9.9 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF5617) Sulfatase PF00884.23 ETO25081.1 - 1.2e-22 80.7 0.0 1.8e-22 80.1 0.0 1.2 1 0 0 1 1 1 1 Sulfatase Sulfatase_C PF14707.6 ETO25081.1 - 8.6e-06 26.5 0.0 1.2e-05 26.0 0.0 1.2 1 0 0 1 1 1 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 ETO25081.1 - 0.19 11.3 0.0 0.28 10.7 0.0 1.2 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 ETO25081.1 - 0.31 10.0 0.0 0.4 9.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) UPF0121 PF03661.13 ETO25082.1 - 0.8 9.1 7.0 1.6 8.1 4.6 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0121) Kelch_2 PF07646.15 ETO25083.1 - 0.00024 21.0 0.4 0.0088 16.0 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO25083.1 - 0.0061 16.8 0.2 3.3 8.1 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO25083.1 - 0.011 15.7 0.0 2.8 8.0 0.2 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ETO25083.1 - 0.1 12.6 1.5 1 9.4 0.2 2.8 1 1 1 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO25083.1 - 0.19 11.3 1.3 2.7 7.6 0.3 3.0 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO25084.1 - 5.6e-58 191.6 20.3 1e-08 35.6 0.1 8.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25084.1 - 1.8e-20 73.0 4.7 0.0008 19.7 0.0 7.9 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25084.1 - 3.1e-12 46.1 0.1 0.085 11.8 0.0 6.1 1 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_2 PF07646.15 ETO25084.1 - 9.7e-06 25.4 5.3 0.0075 16.2 0.4 4.8 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO25084.1 - 1.8e-05 24.2 12.0 0.00026 20.5 1.1 4.1 5 0 0 5 5 5 2 Kelch motif Nup160 PF11715.8 ETO25084.1 - 3.5e-05 22.6 6.7 1 8.0 0.0 4.8 1 1 3 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO25084.1 - 3.6e-05 23.6 0.8 3.2 7.8 0.0 5.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_6 PF13964.6 ETO25084.1 - 0.00032 20.9 8.5 4.2 7.8 1.1 5.3 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO25084.1 - 0.00051 20.0 7.0 0.16 12.0 1.4 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO25084.1 - 0.0059 16.6 0.5 0.51 10.4 0.2 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Cytochrom_D1 PF02239.16 ETO25084.1 - 0.012 14.2 0.1 0.15 10.5 0.1 2.3 1 1 2 3 3 3 0 Cytochrome D1 heme domain Kelch_3 PF13415.6 ETO25084.1 - 0.037 14.3 0.7 2.4 8.6 0.1 3.6 5 0 0 5 5 5 0 Galactose oxidase, central domain WD40 PF00400.32 ETO25085.1 - 2.8e-62 205.2 27.1 2e-09 37.9 0.0 7.9 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25085.1 - 6.9e-21 74.4 4.3 0.0003 21.0 0.0 6.6 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25085.1 - 7e-14 51.5 0.2 0.039 12.9 0.0 6.5 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO25085.1 - 2.9e-08 33.8 0.1 0.27 11.1 0.0 3.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO25085.1 - 3.3e-07 29.4 10.0 0.39 9.3 0.0 6.2 1 1 6 7 7 7 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO25085.1 - 5.4e-07 29.2 0.0 0.1 11.9 0.0 3.7 3 1 1 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO25085.1 - 3e-05 22.7 1.0 1.4 7.4 0.0 3.9 2 2 2 4 4 4 2 Cytochrome D1 heme domain Str_synth PF03088.16 ETO25085.1 - 5.4e-05 23.2 0.2 25 5.1 0.0 5.4 5 1 2 7 7 6 0 Strictosidine synthase PD40 PF07676.12 ETO25085.1 - 0.0003 20.6 0.9 28 4.8 0.0 5.6 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat SoxZ PF08770.11 ETO25085.1 - 0.00091 19.0 0.0 18 5.2 0.0 4.7 5 0 0 5 5 5 0 Sulphur oxidation protein SoxZ DUF5570 PF17731.1 ETO25085.1 - 0.00093 19.3 3.8 14 5.8 0.0 5.5 1 1 6 7 7 7 0 Family of unknown function (DUF5570) AcetylCoA_hyd_C PF13336.6 ETO25085.1 - 0.0061 16.5 0.4 0.5 10.3 0.0 3.2 2 1 1 3 3 3 1 Acetyl-CoA hydrolase/transferase C-terminal domain MMS1_N PF10433.9 ETO25085.1 - 0.0098 14.6 0.0 5.6 5.5 0.0 3.1 1 1 1 3 3 3 2 Mono-functional DNA-alkylating methyl methanesulfonate N-term HPS6 PF15702.5 ETO25085.1 - 0.05 11.6 0.0 0.89 7.5 0.0 2.6 2 2 1 3 3 3 0 Hermansky-Pudlak syndrome 6 protein Proteasome_A_N PF10584.9 ETO25085.1 - 1.4 8.6 11.2 12 5.7 0.0 4.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Alk_phosphatase PF00245.20 ETO25087.1 - 1.8e-38 132.6 0.0 2.2e-37 129.0 0.0 2.1 2 0 0 2 2 2 1 Alkaline phosphatase Metalloenzyme PF01676.18 ETO25087.1 - 0.015 14.7 0.0 0.024 14.0 0.0 1.2 1 0 0 1 1 1 0 Metalloenzyme superfamily Kelch_1 PF01344.25 ETO25088.1 - 0.13 11.8 4.4 0.72 9.5 3.7 2.4 2 0 0 2 2 2 0 Kelch motif Prp19 PF08606.11 ETO25091.1 - 1.6e-32 111.3 2.3 2.5e-32 110.6 2.3 1.3 1 0 0 1 1 1 1 Prp19/Pso4-like zf-Nse PF11789.8 ETO25091.1 - 4e-07 29.7 0.5 7.7e-07 28.8 0.5 1.4 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit U-box PF04564.15 ETO25091.1 - 0.0001 22.4 0.0 0.00026 21.1 0.0 1.7 1 0 0 1 1 1 1 U-box domain DUF3552 PF12072.8 ETO25091.1 - 0.011 15.2 2.9 0.016 14.6 2.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) zf-RING_UBOX PF13445.6 ETO25091.1 - 0.019 15.0 0.9 0.035 14.1 0.9 1.4 1 0 0 1 1 1 0 RING-type zinc-finger Cep57_CLD_2 PF14197.6 ETO25091.1 - 0.11 12.6 2.1 0.28 11.3 2.1 1.7 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 G-alpha PF00503.20 ETO25092.1 - 2.9e-14 53.0 0.4 4e-14 52.6 0.4 1.2 1 0 0 1 1 1 1 G-protein alpha subunit DUF815 PF05673.13 ETO25092.1 - 0.00039 19.7 0.0 0.00059 19.1 0.0 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO25092.1 - 0.00088 19.8 0.0 0.0011 19.5 0.0 1.4 1 1 0 1 1 1 1 ABC transporter SRPRB PF09439.10 ETO25092.1 - 0.00095 18.6 3.2 0.17 11.3 0.1 2.3 1 1 1 2 2 2 2 Signal recognition particle receptor beta subunit Rad17 PF03215.15 ETO25092.1 - 0.0012 18.9 0.0 0.0014 18.6 0.0 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain AAA_16 PF13191.6 ETO25092.1 - 0.0012 19.3 0.0 0.0013 19.1 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO25092.1 - 0.0035 17.7 0.0 0.0055 17.1 0.0 1.4 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 ETO25092.1 - 0.0044 16.2 0.0 0.0056 15.9 0.0 1.3 1 0 0 1 1 1 1 NB-ARC domain ATPase_2 PF01637.18 ETO25092.1 - 0.0051 16.8 0.7 0.0079 16.1 0.7 1.4 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea AAA PF00004.29 ETO25092.1 - 0.0063 16.9 0.0 0.013 16.0 0.0 1.5 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ETO25092.1 - 0.0074 16.2 0.1 0.011 15.6 0.1 1.3 1 1 0 1 1 1 1 RsgA GTPase AAA_24 PF13479.6 ETO25092.1 - 0.0078 16.0 0.1 0.015 15.0 0.1 1.5 1 1 0 1 1 1 1 AAA domain Roc PF08477.13 ETO25092.1 - 0.01 16.1 0.0 0.021 15.1 0.0 1.6 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase AAA_23 PF13476.6 ETO25092.1 - 0.031 14.8 0.6 0.031 14.8 0.6 1.5 1 1 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO25092.1 - 0.031 14.5 0.1 0.044 14.0 0.1 1.6 1 1 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ETO25092.1 - 0.035 14.4 0.0 0.048 13.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO25092.1 - 0.035 13.8 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain PduV-EutP PF10662.9 ETO25092.1 - 0.039 13.7 0.1 0.073 12.8 0.1 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 ETO25092.1 - 0.047 14.2 0.0 0.075 13.6 0.0 1.5 1 0 0 1 1 1 0 AAA domain RuvB_N PF05496.12 ETO25092.1 - 0.048 13.4 0.0 0.061 13.1 0.0 1.1 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain DAP3 PF10236.9 ETO25092.1 - 0.053 12.7 0.1 0.092 11.9 0.1 1.6 1 1 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Mg_chelatase PF01078.21 ETO25092.1 - 0.055 12.9 0.0 0.16 11.3 0.0 1.7 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETO25092.1 - 0.057 13.4 0.1 0.11 12.5 0.1 1.7 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) PRK PF00485.18 ETO25092.1 - 0.059 13.1 0.1 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family PIF1 PF05970.14 ETO25092.1 - 0.082 12.1 0.0 0.13 11.4 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase MMR_HSR1 PF01926.23 ETO25092.1 - 0.18 11.9 2.5 2.8 8.0 0.0 2.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Bromodomain PF00439.25 ETO25093.1 - 0.001 19.1 0.1 0.0019 18.2 0.1 1.4 1 0 0 1 1 1 1 Bromodomain Macoilin PF09726.9 ETO25094.1 - 0.027 13.1 27.7 0.035 12.7 27.7 1.1 1 0 0 1 1 1 0 Macoilin family Cas_Cmr5 PF09701.10 ETO25094.1 - 0.14 12.4 1.6 0.86 9.9 0.0 2.6 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) Rab5-bind PF09311.11 ETO25094.1 - 1 8.7 11.2 0.12 11.8 6.6 1.7 1 1 1 2 2 2 0 Rabaptin-like protein UPF0242 PF06785.11 ETO25094.1 - 1.4 9.0 11.9 0.36 10.9 7.6 1.9 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF3972 PF13118.6 ETO25094.1 - 7.2 7.1 16.5 0.11 12.9 6.8 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3972) NAGLU_N PF12971.7 ETO25095.1 - 9.6e-09 34.9 1.0 9.7e-08 31.7 0.2 2.1 1 1 1 2 2 2 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Peptidase_M56 PF05569.11 ETO25095.1 - 0.013 14.8 0.2 0.017 14.3 0.2 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 NAGLU PF05089.12 ETO25096.1 - 3.3e-76 256.4 1.9 4e-75 252.8 1.9 2.3 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 ETO25096.1 - 1.5e-36 126.3 9.7 2.8e-36 125.4 9.7 1.4 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain NAGLU PF05089.12 ETO25097.1 - 1.7e-41 142.3 1.2 2.9e-40 138.3 1.2 2.4 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain NAGLU_C PF12972.7 ETO25097.1 - 1.2e-36 126.6 9.9 2e-36 125.9 9.9 1.3 1 0 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain RhoGEF PF00621.20 ETO25098.1 - 0.00012 22.4 0.5 0.00029 21.1 0.5 1.7 1 1 0 1 1 1 1 RhoGEF domain PT PF04886.12 ETO25099.1 - 7.7e-123 399.7 861.3 1.1e-07 31.3 26.4 40.8 5 2 19 24 24 24 14 PT repeat SPRY PF00622.28 ETO25100.1 - 2.1e-14 53.6 1.8 4.9e-12 46.0 0.5 2.5 2 1 1 3 3 3 2 SPRY domain DUF4982 PF16355.5 ETO25100.1 - 0.015 15.2 0.2 0.1 12.6 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4982) Glyco_hydro_53 PF07745.13 ETO25101.1 - 1.7e-14 53.6 0.1 1.4e-12 47.3 0.1 2.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 53 Tox-PLDMTX PF15645.6 ETO25101.1 - 0.041 14.2 0.1 0.077 13.3 0.1 1.4 1 0 0 1 1 1 0 Dermonecrotoxin of the Papain-like fold Trp_ring PF18669.1 ETO25102.1 - 0.36 11.0 2.0 0.73 10.1 2.0 1.5 1 0 0 1 1 1 0 Trimeric autotransporter adhesin Trp ring domain Thiolase_N PF00108.23 ETO25103.1 - 4.9e-51 173.6 0.2 2.6e-48 164.7 0.0 2.6 2 1 0 2 2 2 2 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETO25103.1 - 1.7e-26 92.3 0.0 3.7e-26 91.2 0.0 1.5 1 0 0 1 1 1 1 Thiolase, C-terminal domain ketoacyl-synt PF00109.26 ETO25103.1 - 0.033 13.8 0.5 0.068 12.7 0.5 1.5 1 0 0 1 1 1 0 Beta-ketoacyl synthase, N-terminal domain ACP_syn_III_C PF08541.10 ETO25103.1 - 0.065 13.4 0.0 0.35 11.1 0.0 2.3 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal DUF2256 PF10013.9 ETO25103.1 - 0.18 12.0 0.0 0.37 11.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2256) Adaptin_N PF01602.20 ETO25104.1 - 4.7e-16 58.4 0.1 5.7e-16 58.2 0.1 1.1 1 0 0 1 1 1 1 Adaptin N terminal region LAP1C PF05609.12 ETO25105.1 - 1.4 7.9 25.6 1.8 7.6 25.6 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) ANAPC15 PF15243.6 ETO25106.1 - 0.023 15.1 10.9 0.023 15.1 10.9 2.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 Merozoite_SPAM PF07133.11 ETO25106.1 - 0.026 14.5 51.2 0.35 10.8 21.1 3.5 3 0 0 3 3 3 0 Merozoite surface protein (SPAM) SDA1 PF05285.12 ETO25106.1 - 0.045 13.2 33.0 0.36 10.2 16.0 2.3 2 0 0 2 2 2 0 SDA1 BSP_II PF05432.11 ETO25106.1 - 0.088 12.5 27.4 0.72 9.5 12.9 2.5 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) Nop14 PF04147.12 ETO25106.1 - 0.17 10.0 37.4 0.46 8.6 16.1 2.2 2 0 0 2 2 2 0 Nop14-like family Myc_N PF01056.18 ETO25106.1 - 0.54 10.1 27.5 0.08 12.8 9.3 2.6 2 1 0 2 2 2 0 Myc amino-terminal region Sigma70_ner PF04546.13 ETO25106.1 - 0.72 9.7 29.0 1.8 8.4 13.2 2.6 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF5520 PF17658.1 ETO25106.1 - 5.6 6.0 18.5 2.1 7.4 1.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5520) DUF3408 PF11888.8 ETO25106.1 - 5.8 7.0 20.9 2.2 8.4 4.4 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) BUD22 PF09073.10 ETO25106.1 - 9 5.5 38.8 7.4 5.8 20.0 2.4 2 0 0 2 2 2 0 BUD22 TRAP_alpha PF03896.16 ETO25106.1 - 9.4 5.4 23.9 1.5 7.9 4.7 2.3 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.22 ETO25108.1 - 0.14 11.4 5.1 0.26 10.4 5.1 1.4 1 1 0 1 1 1 0 ZIP Zinc transporter Pkinase PF00069.25 ETO25109.1 - 1e-05 25.1 0.1 1e-05 25.1 0.1 1.9 2 0 0 2 2 2 1 Protein kinase domain DUF5011 PF16403.5 ETO25109.1 - 0.099 12.8 1.1 0.16 12.1 1.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF5011) Pkinase_Tyr PF07714.17 ETO25109.1 - 0.11 11.8 0.5 0.18 11.0 0.0 1.6 2 0 0 2 2 2 0 Protein tyrosine kinase Pinin_SDK_N PF04697.13 ETO25109.1 - 0.16 12.7 6.3 0.16 12.6 3.3 2.1 1 1 1 2 2 2 0 pinin/SDK conserved region DUF4407 PF14362.6 ETO25109.1 - 3.7 6.8 6.2 4.1 6.7 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Arm_3 PF16186.5 ETO25110.1 - 9e-05 22.0 0.5 0.00027 20.4 0.5 1.8 1 1 0 1 1 1 1 Atypical Arm repeat HEAT_EZ PF13513.6 ETO25110.1 - 0.015 15.8 0.0 0.03 14.8 0.0 1.5 1 0 0 1 1 1 0 HEAT-like repeat DUF5112 PF17139.4 ETO25110.1 - 0.026 14.0 0.2 0.036 13.5 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5112) Arm PF00514.23 ETO25110.1 - 0.21 11.7 4.4 21 5.3 0.2 3.6 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat FeoB_associated PF12669.7 ETO25110.1 - 0.56 10.6 8.0 4.2 7.8 0.5 2.7 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein Bac_rhamnosid_N PF08531.10 ETO25111.1 - 0.0011 18.8 0.0 0.0023 17.8 0.0 1.5 1 0 0 1 1 1 1 Alpha-L-rhamnosidase N-terminal domain HEAT_2 PF13646.6 ETO25112.1 - 4.2e-06 27.1 0.0 0.0088 16.4 0.0 2.4 2 0 0 2 2 2 2 HEAT repeats Cnd3 PF12719.7 ETO25112.1 - 0.0002 20.7 0.6 0.0021 17.3 0.0 2.5 1 1 1 2 2 2 2 Nuclear condensing complex subunits, C-term domain Vac14_Fab1_bd PF12755.7 ETO25112.1 - 0.00031 21.3 1.5 0.14 12.7 0.3 2.8 1 1 1 2 2 2 2 Vacuolar 14 Fab1-binding region YniB PF14002.6 ETO25112.1 - 0.00046 20.0 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 YniB-like protein Adaptin_N PF01602.20 ETO25112.1 - 0.00051 18.7 0.1 0.0011 17.7 0.1 1.5 1 0 0 1 1 1 1 Adaptin N terminal region BP28CT PF08146.12 ETO25112.1 - 0.0017 18.2 1.8 0.81 9.5 0.1 3.2 2 1 1 3 3 3 2 BP28CT (NUC211) domain HEAT PF02985.22 ETO25112.1 - 0.0028 17.8 0.0 0.29 11.5 0.0 3.4 3 0 0 3 3 3 1 HEAT repeat Cnd1 PF12717.7 ETO25112.1 - 0.0073 16.4 4.4 0.029 14.4 1.0 2.5 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 IL31 PF15209.6 ETO25112.1 - 0.065 13.0 0.1 7.1 6.4 0.0 2.7 2 0 0 2 2 2 0 Interleukin 31 GRAB PF10375.9 ETO25113.1 - 0.0043 16.9 0.1 0.0092 15.8 0.1 1.6 1 0 0 1 1 1 1 GRIP-related Arf-binding domain hGDE_central PF14702.6 ETO25113.1 - 0.12 12.0 1.8 1.3 8.7 0.2 2.2 2 0 0 2 2 2 0 Central domain of human glycogen debranching enzyme Cwf_Cwc_15 PF04889.12 ETO25115.1 - 0.18 11.5 17.1 0.29 10.8 17.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Neur_chan_memb PF02932.16 ETO25115.1 - 0.44 10.6 1.1 0.51 10.3 1.1 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Menin PF05053.13 ETO25115.1 - 1.1 7.5 10.3 1.5 7.1 10.3 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO25115.1 - 1.6 7.4 6.5 1.9 7.1 6.5 1.1 1 0 0 1 1 1 0 Presenilin TFB6 PF17110.5 ETO25115.1 - 8.6 6.1 9.9 3.1 7.5 0.3 2.2 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CD36 PF01130.21 ETO25116.1 - 8.5e-26 90.5 4.7 9.4e-26 90.4 4.7 1.1 1 0 0 1 1 1 1 CD36 family CD36 PF01130.21 ETO25117.1 - 8.5e-35 120.2 0.1 1e-34 119.9 0.1 1.0 1 0 0 1 1 1 1 CD36 family DUF3341 PF11821.8 ETO25117.1 - 0.071 12.7 0.1 0.11 12.1 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) MAF_flag10 PF01973.18 ETO25117.1 - 0.15 11.8 0.1 0.4 10.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function DUF115 HSP90 PF00183.18 ETO25118.1 - 6.4e-95 319.0 3.3 6.7e-91 305.7 1.7 2.4 1 1 1 2 2 2 2 Hsp90 protein NSP10 PF09401.10 ETO25118.1 - 0.0042 17.1 0.0 1.3 9.1 0.0 2.4 2 0 0 2 2 2 2 RNA synthesis protein NSP10 ERp29 PF07749.12 ETO25118.1 - 3.5 8.6 7.3 7.2 7.6 1.0 3.6 3 0 0 3 3 3 0 Endoplasmic reticulum protein ERp29, C-terminal domain Sedlin_N PF04628.13 ETO25118.1 - 5.1 7.2 6.0 64 3.7 0.2 3.2 2 1 0 2 2 2 0 Sedlin, N-terminal conserved region CAP_GLY PF01302.25 ETO25120.1 - 3.2e-09 36.7 0.2 7.8e-09 35.4 0.2 1.6 1 0 0 1 1 1 1 CAP-Gly domain Peptidase_M43 PF05572.13 ETO25121.1 - 6.2e-05 23.0 1.3 0.00034 20.6 0.3 2.2 2 0 0 2 2 2 1 Pregnancy-associated plasma protein-A DASH_Ask1 PF08655.10 ETO25122.1 - 0.034 14.1 0.0 0.082 12.8 0.0 1.6 2 0 0 2 2 2 0 DASH complex subunit Ask1 Radial_spoke_3 PF06098.11 ETO25123.1 - 7.7e-67 225.6 4.0 1e-66 225.2 4.0 1.1 1 0 0 1 1 1 1 Radial spoke protein 3 HisK_N PF09385.10 ETO25123.1 - 0.029 14.3 2.0 0.071 13.1 2.0 1.7 1 0 0 1 1 1 0 Histidine kinase N terminal PDDEXK_3 PF13366.6 ETO25123.1 - 0.18 12.2 3.4 0.37 11.2 3.4 1.5 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily RF-1 PF00472.20 ETO25123.1 - 2.7 8.0 8.1 1.2 9.1 3.4 2.4 3 0 0 3 3 3 0 RF-1 domain YlqD PF11068.8 ETO25123.1 - 2.7 8.4 10.1 0.52 10.7 6.1 1.8 2 0 0 2 2 2 0 YlqD protein SAM_2 PF07647.17 ETO25125.1 - 0.0074 16.4 0.2 0.032 14.3 0.2 2.1 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF5463 PF17551.2 ETO25126.1 - 0.23 11.4 2.7 0.22 11.5 0.9 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5463) HKR_ArcB_TM PF18415.1 ETO25127.1 - 0.072 13.9 0.7 0.39 11.5 0.0 2.4 2 1 1 3 3 3 0 Histidine kinase receptor ArcB trans-membrane domain KH_1 PF00013.29 ETO25128.1 - 0.0088 15.9 0.0 0.014 15.2 0.0 1.3 1 0 0 1 1 1 1 KH domain KH_1 PF00013.29 ETO25129.1 - 2.9e-05 23.8 0.0 9.6e-05 22.1 0.0 1.9 1 0 0 1 1 1 1 KH domain RRM_1 PF00076.22 ETO25129.1 - 0.0044 16.8 0.0 0.61 9.9 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO25129.1 - 0.15 12.1 0.1 0.61 10.1 0.0 2.1 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif Hat1_N PF10394.9 ETO25130.1 - 1.3e-28 100.3 1.9 1.3e-28 100.3 1.9 2.9 3 2 0 3 3 3 1 Histone acetyl transferase HAT1 N-terminus Acetyltransf_1 PF00583.25 ETO25130.1 - 0.0043 17.3 0.0 0.012 15.9 0.0 1.8 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family MOZ_SAS PF01853.18 ETO25130.1 - 0.011 15.4 0.5 0.027 14.1 0.5 1.7 1 0 0 1 1 1 0 MOZ/SAS family Kringle PF00051.18 ETO25130.1 - 0.2 12.0 4.4 0.5 10.7 4.4 1.6 1 0 0 1 1 1 0 Kringle domain Vps51 PF08700.11 ETO25131.1 - 2.6e-07 30.6 0.9 2.6e-07 30.6 0.9 2.4 2 1 0 2 2 2 1 Vps51/Vps67 Zw10 PF06248.13 ETO25131.1 - 1.6e-05 23.7 8.0 2.1e-05 23.3 8.0 1.1 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 DUF16 PF01519.16 ETO25131.1 - 0.0049 17.3 4.5 0.011 16.2 4.5 1.6 1 0 0 1 1 1 1 Protein of unknown function DUF16 COG2 PF06148.11 ETO25131.1 - 0.046 13.8 4.9 0.089 12.9 4.9 1.6 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 Phage_Nu1 PF07471.12 ETO25131.1 - 0.057 13.2 0.3 0.093 12.5 0.3 1.4 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 UL45 PF05473.12 ETO25131.1 - 0.072 12.7 0.1 0.14 11.8 0.1 1.4 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like DUF4988 PF16378.5 ETO25131.1 - 0.28 10.9 4.4 1.7 8.3 2.4 2.5 2 1 0 2 2 2 0 Domain of unknown function DUF1002 PF06207.11 ETO25131.1 - 0.92 9.0 7.3 1.3 8.5 5.9 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) TssO PF17561.2 ETO25132.1 - 0.012 15.7 4.5 0.012 15.7 4.5 2.1 2 0 0 2 2 2 0 Type VI secretion system, TssO DUF2070 PF09843.9 ETO25132.1 - 0.052 11.8 6.5 0.027 12.8 5.0 1.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2070) Adaptin_N PF01602.20 ETO25133.1 - 1.5e-62 211.9 9.5 1.8e-62 211.6 9.5 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Alpha_adaptinC2 PF02883.20 ETO25133.1 - 3.9e-16 59.3 3.7 1.1e-15 57.9 3.7 1.8 1 0 0 1 1 1 1 Adaptin C-terminal domain Peptidase_M9_N PF08453.10 ETO25133.1 - 0.0082 15.9 0.7 2.4 7.8 0.0 2.6 2 0 0 2 2 2 2 Peptidase family M9 N-terminal IrmA PF18673.1 ETO25133.1 - 0.028 14.5 0.0 0.11 12.7 0.0 1.9 1 0 0 1 1 1 0 interleukin receptor mimic protein A RICTOR_M PF14666.6 ETO25133.1 - 0.053 13.3 1.7 19 5.1 0.1 3.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain Cnd1 PF12717.7 ETO25133.1 - 0.07 13.2 10.9 0.036 14.1 4.2 3.1 2 1 1 3 3 3 0 non-SMC mitotic condensation complex subunit 1 UTP15_C PF09384.10 ETO25133.1 - 0.11 12.1 2.6 0.47 10.1 0.6 2.4 2 1 1 3 3 3 0 UTP15 C terminal RIG-I_C PF18119.1 ETO25133.1 - 0.21 11.6 3.2 0.22 11.5 0.2 2.6 4 0 0 4 4 4 0 RIG-I receptor C-terminal domain AF0941-like PF14591.6 ETO25133.1 - 1.7 9.2 5.2 60 4.2 0.8 3.5 3 0 0 3 3 3 0 AF0941-like Gal_mutarotas_2 PF13802.6 ETO25134.1 - 5.8e-08 32.9 0.0 1.3e-07 31.8 0.0 1.7 1 1 0 1 1 1 1 Galactose mutarotase-like Replic_Relax PF13814.6 ETO25134.1 - 0.044 13.9 0.1 0.048 13.7 0.1 1.1 1 0 0 1 1 1 0 Replication-relaxation ACAS_N PF16177.5 ETO25134.1 - 0.046 13.6 0.1 0.077 12.9 0.1 1.4 1 0 0 1 1 1 0 Acetyl-coenzyme A synthetase N-terminus Glyco_hydro_31 PF01055.26 ETO25135.1 - 8.3e-129 430.6 8.3 1e-128 430.3 8.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 ETO25135.1 - 0.0003 21.0 0.0 0.00061 20.0 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Kelch_1 PF01344.25 ETO25136.1 - 8.2e-06 25.3 2.0 0.00025 20.5 0.3 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO25136.1 - 0.0004 20.3 0.1 0.0057 16.6 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO25136.1 - 0.0007 19.8 8.8 0.0048 17.1 0.1 4.1 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO25136.1 - 0.00079 19.6 0.0 0.018 15.3 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO25136.1 - 0.004 17.1 1.2 0.11 12.5 0.2 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO25136.1 - 0.17 11.9 2.4 0.92 9.6 0.7 2.8 3 0 0 3 3 3 0 Kelch motif zf-TRAF PF02176.18 ETO25137.1 - 1.7e-07 31.8 8.9 1.7e-07 31.8 8.9 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger Spc7 PF08317.11 ETO25137.1 - 0.00056 18.9 1.4 0.00092 18.2 1.4 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein HMMR_C PF15908.5 ETO25137.1 - 0.016 15.4 1.3 0.034 14.4 1.3 1.6 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor C-terminal CorA PF01544.18 ETO25137.1 - 0.019 14.3 0.2 0.028 13.7 0.2 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein PCRF PF03462.18 ETO25137.1 - 0.03 14.2 2.0 0.062 13.2 2.0 1.4 1 0 0 1 1 1 0 PCRF domain bZIP_1 PF00170.21 ETO25137.1 - 0.033 14.3 4.2 0.72 10.0 0.3 2.6 2 0 0 2 2 2 0 bZIP transcription factor DUF2570 PF10828.8 ETO25137.1 - 0.16 11.8 3.0 0.11 12.3 0.6 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) FadA PF09403.10 ETO25137.1 - 0.26 11.8 5.4 0.56 10.7 5.4 1.6 1 0 0 1 1 1 0 Adhesion protein FadA zf-TRAF_2 PF15965.5 ETO25137.1 - 0.66 10.5 13.9 1.4 9.4 13.6 1.7 1 1 1 2 2 2 0 TRAF-like zinc-finger PMSR PF01625.21 ETO25138.1 - 4.9e-13 49.5 2.5 5.3e-13 49.4 0.1 2.1 2 0 0 2 2 2 1 Peptide methionine sulfoxide reductase DUF3290 PF11694.8 ETO25138.1 - 0.011 15.7 1.7 0.019 14.9 1.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) CaKB PF03185.15 ETO25138.1 - 0.025 14.2 0.6 0.025 14.2 0.6 1.8 2 0 0 2 2 2 0 Calcium-activated potassium channel, beta subunit Sensor_TM1 PF13755.6 ETO25138.1 - 0.15 11.8 0.0 0.33 10.7 0.0 1.6 1 0 0 1 1 1 0 Sensor N-terminal transmembrane domain NUDIX PF00293.28 ETO25139.1 - 7.4e-08 32.5 0.3 1.1e-07 32.0 0.3 1.3 1 0 0 1 1 1 1 NUDIX domain Saf_2TM PF18303.1 ETO25139.1 - 0.15 11.7 0.5 0.22 11.1 0.5 1.2 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain G-alpha PF00503.20 ETO25140.1 - 1.3e-08 34.4 1.2 1.3e-08 34.4 1.2 2.0 2 0 0 2 2 2 1 G-protein alpha subunit Fas_alpha_ACP PF18325.1 ETO25140.1 - 0.029 14.7 0.0 0.035 14.4 0.0 1.1 1 0 0 1 1 1 0 Fatty acid synthase subunit alpha Acyl carrier domain Rep_1 PF01446.17 ETO25140.1 - 0.09 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Replication protein PA26 PF04636.13 ETO25141.1 - 2.3 7.0 14.6 2.9 6.7 14.6 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Zip PF02535.22 ETO25141.1 - 2.4 7.3 11.6 2.8 7.1 11.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO25141.1 - 3.1 6.5 19.8 3.8 6.2 19.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO25141.1 - 3.3 5.9 20.1 4.3 5.6 20.1 1.2 1 0 0 1 1 1 0 Menin DUF4551 PF15087.6 ETO25141.1 - 4 6.1 11.2 4.4 6.0 11.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Presenilin PF01080.17 ETO25141.1 - 4.8 5.8 20.5 6 5.5 20.5 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO25141.1 - 6 5.8 19.0 7.5 5.5 19.0 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 ETO25141.1 - 6.5 5.3 8.8 7.8 5.1 8.8 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAP_GLY PF01302.25 ETO25143.1 - 6.4e-32 109.4 5.7 3.1e-17 62.3 0.3 2.2 2 0 0 2 2 2 2 CAP-Gly domain Slu7 PF11708.8 ETO25144.1 - 1.6e-42 146.1 0.5 1.6e-42 146.1 0.5 2.1 2 0 0 2 2 2 1 Pre-mRNA splicing Prp18-interacting factor YlaH PF14036.6 ETO25144.1 - 1.3 9.4 4.0 2 8.8 4.0 1.2 1 0 0 1 1 1 0 YlaH-like protein 23S_rRNA_IVP PF05635.11 ETO25145.1 - 0.049 13.9 0.2 0.073 13.4 0.2 1.2 1 0 0 1 1 1 0 23S rRNA-intervening sequence protein MFS_1 PF07690.16 ETO25145.1 - 0.29 10.0 13.8 0.072 12.0 9.2 1.6 1 1 0 1 1 1 0 Major Facilitator Superfamily Sulfotransfer_2 PF03567.14 ETO25146.1 - 2.6e-06 27.5 0.4 3.3e-06 27.2 0.4 1.1 1 0 0 1 1 1 1 Sulfotransferase family G-alpha PF00503.20 ETO25147.1 - 2e-16 60.1 1.9 2.4e-16 59.9 1.9 1.0 1 0 0 1 1 1 1 G-protein alpha subunit AAA_lid_8 PF17868.1 ETO25147.1 - 0.073 13.0 0.5 0.25 11.2 0.1 2.2 1 1 1 2 2 2 0 AAA lid domain G-alpha PF00503.20 ETO25148.1 - 1.3e-43 149.6 2.3 1.7e-43 149.1 2.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO25148.1 - 7.8e-11 41.7 0.2 1.4e-10 40.9 0.2 1.5 1 1 0 1 1 1 1 ADP-ribosylation factor family DUF4781 PF16013.5 ETO25149.1 - 0.01 14.7 0.1 0.011 14.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) RasGAP PF00616.19 ETO25151.1 - 1.9e-42 145.3 1.2 1.7e-30 106.3 0.7 2.6 2 0 0 2 2 2 2 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ETO25151.1 - 1.1e-13 51.6 1.1 1.1e-13 51.6 1.1 2.4 2 1 1 3 3 3 1 RasGAP C-terminus LOH1CR12 PF10158.9 ETO25151.1 - 0.031 14.3 0.9 2.3 8.3 0.0 3.1 2 0 0 2 2 2 0 Tumour suppressor protein CREPT PF16566.5 ETO25151.1 - 0.083 13.1 1.8 5.9 7.0 0.2 3.3 3 0 0 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour YkyA PF10368.9 ETO25151.1 - 0.25 11.0 2.5 1 9.0 0.0 2.6 2 0 0 2 2 2 0 Putative cell-wall binding lipoprotein Hrs_helical PF12210.8 ETO25151.1 - 0.6 10.7 9.1 2.5 8.7 0.0 4.1 4 0 0 4 4 4 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Ank_2 PF12796.7 ETO25152.1 - 6.7e-20 71.5 1.0 8.7e-11 42.3 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO25152.1 - 6.5e-19 68.0 0.2 6e-08 33.1 0.0 4.0 3 1 1 4 4 4 4 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO25152.1 - 3.2e-16 59.2 0.2 8.3e-08 32.4 0.2 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO25152.1 - 7.1e-14 50.6 0.2 0.0011 19.3 0.0 4.9 5 1 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ETO25152.1 - 1.2e-12 47.6 0.0 0.00085 19.7 0.1 4.6 5 0 0 5 5 5 3 Ankyrin repeat DUF4746 PF15928.5 ETO25153.1 - 0.012 15.0 1.4 0.017 14.6 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) SOG2 PF10428.9 ETO25153.1 - 0.042 13.1 0.0 0.048 12.9 0.0 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Miff PF05644.11 ETO25153.1 - 0.05 13.2 0.8 0.07 12.7 0.8 1.1 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff DUF913 PF06025.12 ETO25153.1 - 0.06 12.3 0.1 4 6.3 0.1 2.0 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF5489 PF17592.2 ETO25153.1 - 0.12 12.9 0.0 0.19 12.3 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5489) DUF3314 PF11771.8 ETO25154.1 - 0.00098 19.3 0.1 0.0013 18.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3314) ThiD2 PF17792.1 ETO25154.1 - 0.0057 17.1 2.9 0.01 16.3 2.9 1.4 1 0 0 1 1 1 1 ThiD2 family FapA PF03961.13 ETO25154.1 - 0.044 12.4 2.3 0.044 12.4 2.3 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A PsbI PF02532.14 ETO25154.1 - 0.49 10.4 2.8 3.3 7.7 2.0 2.3 2 0 0 2 2 2 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) Lactonase PF10282.9 ETO25156.1 - 0.22 10.7 0.0 3 7.0 0.0 2.0 2 0 0 2 2 2 0 Lactonase, 7-bladed beta-propeller Pkinase PF00069.25 ETO25157.1 - 0.0099 15.3 0.0 0.019 14.3 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain FTA2 PF13095.6 ETO25157.1 - 0.072 12.7 0.0 0.1 12.2 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 HAD_SAK_2 PF18143.1 ETO25158.1 - 3.1e-13 50.2 0.1 7.5e-13 49.0 0.1 1.6 1 0 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins CPSF100_C PF13299.6 ETO25158.1 - 0.46 10.6 5.5 1.4 9.1 5.5 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Usp PF00582.26 ETO25158.1 - 8.2 6.9 9.0 0.51 10.8 2.5 2.0 2 0 0 2 2 2 0 Universal stress protein family Globin PF00042.22 ETO25159.1 - 1.1e-10 42.0 1.0 2.1e-08 34.7 0.2 3.0 2 1 0 2 2 2 2 Globin Arabino_trans_C PF14896.6 ETO25160.1 - 0.061 12.3 0.6 0.081 11.9 0.6 1.1 1 0 0 1 1 1 0 EmbC C-terminal domain AAA PF00004.29 ETO25161.1 - 9.1e-41 139.4 0.0 2.2e-40 138.1 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO25161.1 - 4.8e-09 35.9 0.0 1.4e-08 34.4 0.0 1.8 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ETO25161.1 - 1.2e-05 25.5 0.0 1.2e-05 25.5 0.0 2.7 3 1 0 3 3 2 1 AAA domain (Cdc48 subfamily) AAA_5 PF07728.14 ETO25161.1 - 2.6e-05 24.2 0.0 0.00012 22.1 0.0 2.3 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO25161.1 - 8.6e-05 22.8 0.1 0.006 16.9 0.0 2.5 1 1 1 2 2 2 1 AAA domain DUF815 PF05673.13 ETO25161.1 - 0.00036 19.8 0.1 0.0012 18.1 0.0 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 ETO25161.1 - 0.00054 20.4 0.1 0.0019 18.6 0.1 1.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 ETO25161.1 - 0.00066 19.5 0.0 0.0014 18.4 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain RNA_helicase PF00910.22 ETO25161.1 - 0.0033 17.8 0.0 0.017 15.5 0.0 2.2 2 0 0 2 2 2 1 RNA helicase AAA_33 PF13671.6 ETO25161.1 - 0.015 15.5 0.5 0.033 14.4 0.0 1.9 2 0 0 2 2 1 0 AAA domain AAA_28 PF13521.6 ETO25161.1 - 0.016 15.5 0.8 0.028 14.7 0.0 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETO25161.1 - 0.018 14.5 0.0 0.037 13.5 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_3 PF07726.11 ETO25161.1 - 0.037 13.9 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ETO25161.1 - 0.049 13.7 0.1 0.21 11.6 0.0 2.1 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ETO25161.1 - 0.05 13.0 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activ_2 PF14532.6 ETO25161.1 - 0.054 13.6 0.0 0.12 12.4 0.0 1.6 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_24 PF13479.6 ETO25161.1 - 0.058 13.1 1.5 0.14 11.8 0.1 2.4 2 1 0 2 2 2 0 AAA domain AAA_18 PF13238.6 ETO25161.1 - 0.066 13.8 1.5 0.18 12.3 0.0 2.5 3 0 0 3 3 2 0 AAA domain Sigma54_activat PF00158.26 ETO25161.1 - 0.089 12.5 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain IstB_IS21 PF01695.17 ETO25161.1 - 0.13 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_11 PF13086.6 ETO25161.1 - 0.63 9.8 0.0 0.63 9.8 0.0 2.8 2 1 0 2 2 1 0 AAA domain FAM176 PF14851.6 ETO25161.1 - 3.2 7.4 5.0 6 6.5 5.0 1.4 1 0 0 1 1 1 0 FAM176 family Pyr_redox_2 PF07992.14 ETO25162.1 - 3.1e-15 56.2 0.0 3.7e-15 55.9 0.0 1.0 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO25162.1 - 0.067 13.8 1.3 19 5.9 0.8 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase HECT PF00632.25 ETO25163.1 - 4.6e-70 236.5 0.1 1.2e-69 235.2 0.1 1.7 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ETO25163.1 - 4.1e-11 43.1 0.2 1.2e-10 41.5 0.2 1.9 1 0 0 1 1 1 1 SPRY domain Laminin_G_3 PF13385.6 ETO25164.1 - 3.2e-19 69.6 0.3 7e-19 68.5 0.3 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4983 PF16356.5 ETO25164.1 - 0.053 14.3 0.0 0.2 12.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4983) TniB PF05621.11 ETO25164.1 - 0.073 12.5 0.0 4.6 6.6 0.0 2.2 2 0 0 2 2 2 0 Bacterial TniB protein Pentaxin PF00354.17 ETO25164.1 - 0.089 12.5 0.0 0.38 10.4 0.0 1.8 1 1 0 1 1 1 0 Pentaxin family Ion_trans PF00520.31 ETO25165.1 - 0.024 13.9 0.0 0.032 13.5 0.0 1.1 1 0 0 1 1 1 0 Ion transport protein Kri1 PF05178.12 ETO25165.1 - 0.13 12.9 1.6 9.2 6.9 0.9 2.2 2 0 0 2 2 2 0 KRI1-like family Circo_capsid PF02443.15 ETO25167.1 - 0.58 9.7 10.0 0.57 9.7 10.0 1.2 1 0 0 1 1 1 0 Circovirus capsid protein Nop25 PF09805.9 ETO25167.1 - 1.9 9.0 38.1 2.9 8.4 38.1 1.2 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) WD40 PF00400.32 ETO25168.1 - 0.00093 20.0 0.1 0.026 15.4 0.0 2.3 2 0 0 2 2 2 1 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO25168.1 - 0.013 14.5 0.0 0.016 14.2 0.0 1.2 1 0 0 1 1 1 0 WD40 region of Ge1, enhancer of mRNA-decapping protein MS_channel PF00924.18 ETO25170.1 - 0.48 9.9 4.3 0.14 11.7 0.7 2.0 2 1 0 2 2 2 0 Mechanosensitive ion channel zf-C4H2 PF10146.9 ETO25170.1 - 0.5 10.6 29.1 0.013 15.8 12.3 2.3 2 0 0 2 2 2 0 Zinc finger-containing protein GAS PF13851.6 ETO25170.1 - 1.8 7.8 46.2 0.33 10.3 16.2 2.6 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding FlaC_arch PF05377.11 ETO25170.1 - 2.1 8.8 15.2 1.6 9.2 0.9 4.2 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Dockerin_1 PF00404.18 ETO25171.1 - 0.055 13.7 0.3 0.2 11.9 0.1 1.9 2 0 0 2 2 2 0 Dockerin type I domain RsgA_GTPase PF03193.16 ETO25173.1 - 4.7e-05 23.4 1.6 0.00031 20.7 1.6 2.2 1 1 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO25173.1 - 0.00018 21.6 0.1 0.00018 21.6 0.1 2.4 3 1 0 3 3 3 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO25173.1 - 0.00027 21.5 0.2 0.00027 21.5 0.2 2.2 1 1 1 2 2 2 1 ABC transporter PPV_E1_C PF00519.17 ETO25173.1 - 0.0006 18.8 1.0 0.4 9.5 0.5 2.3 2 0 0 2 2 2 2 Papillomavirus helicase AAA_19 PF13245.6 ETO25173.1 - 0.0013 19.1 0.2 0.0055 17.0 0.1 2.0 1 1 0 2 2 2 1 AAA domain AAA_29 PF13555.6 ETO25173.1 - 0.0085 15.8 0.0 0.017 14.9 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain T2SSE PF00437.20 ETO25173.1 - 0.0088 15.1 0.0 0.012 14.7 0.0 1.3 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_22 PF13401.6 ETO25173.1 - 0.013 15.8 0.0 0.033 14.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO25173.1 - 0.015 15.7 0.2 0.16 12.4 0.0 2.7 2 1 0 2 2 2 0 RNA helicase PhoH PF02562.16 ETO25173.1 - 0.033 13.6 1.7 0.034 13.6 0.1 1.8 2 0 0 2 2 2 0 PhoH-like protein AAA_30 PF13604.6 ETO25173.1 - 0.062 13.0 0.3 0.3 10.8 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_28 PF13521.6 ETO25173.1 - 0.068 13.4 1.6 0.083 13.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain DUF4611 PF15387.6 ETO25173.1 - 0.074 13.3 10.0 0.22 11.8 10.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) AAA_23 PF13476.6 ETO25173.1 - 0.11 13.0 0.4 0.11 13.0 0.4 2.6 1 1 1 2 2 1 0 AAA domain AAA_16 PF13191.6 ETO25173.1 - 0.11 12.8 0.0 0.21 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain LRAT PF04970.13 ETO25173.1 - 0.23 11.8 4.8 0.49 10.7 4.4 1.9 1 1 0 1 1 1 0 Lecithin retinol acyltransferase FtsK_SpoIIIE PF01580.18 ETO25173.1 - 0.38 10.1 3.9 0.15 11.3 0.2 1.9 1 1 1 2 2 2 0 FtsK/SpoIIIE family FAM176 PF14851.6 ETO25173.1 - 0.42 10.3 9.0 0.98 9.1 9.0 1.5 1 0 0 1 1 1 0 FAM176 family RPN2_C PF18004.1 ETO25173.1 - 0.9 9.4 15.9 2 8.3 15.9 1.5 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2076 PF09849.9 ETO25173.1 - 7 6.6 9.2 11 6.0 9.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) LRRNT_2 PF08263.12 ETO25175.1 - 2.4e-05 24.5 1.3 5.8e-05 23.3 1.3 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_8 PF13855.6 ETO25175.1 - 8.7e-05 22.2 2.6 0.0031 17.2 0.2 2.3 2 0 0 2 2 2 2 Leucine rich repeat LRR_4 PF12799.7 ETO25175.1 - 0.0006 20.1 7.1 0.071 13.6 1.9 2.4 2 0 0 2 2 2 2 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO25175.1 - 0.66 10.7 7.7 4.2 8.3 0.3 4.0 4 0 0 4 4 4 0 Leucine Rich Repeat SSP160 PF06933.11 ETO25176.1 - 0.0059 14.9 4.4 0.0079 14.5 4.4 1.1 1 0 0 1 1 1 1 Special lobe-specific silk protein SSP160 DUF4377 PF14302.6 ETO25176.1 - 1.7 8.8 5.2 21 5.3 0.0 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4377) SAM_2 PF07647.17 ETO25177.1 - 0.00073 19.6 0.0 0.0017 18.4 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO25177.1 - 0.0023 18.3 0.1 0.0056 17.1 0.1 1.7 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO25177.1 - 0.0065 16.4 0.1 0.014 15.4 0.1 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Spt5_N PF11942.8 ETO25177.1 - 0.013 16.5 8.5 0.77 10.8 0.4 2.9 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal SAM_Ste50p PF09235.10 ETO25177.1 - 0.026 14.7 0.0 0.068 13.4 0.0 1.7 1 0 0 1 1 1 0 Ste50p, sterile alpha motif CENP-B_dimeris PF09026.10 ETO25177.1 - 0.089 13.2 0.5 0.089 13.2 0.5 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ICL PF00463.21 ETO25178.1 - 5.4e-09 35.1 0.0 6.4e-09 34.8 0.0 1.0 1 0 0 1 1 1 1 Isocitrate lyase family PEP_mutase PF13714.6 ETO25178.1 - 2.7e-06 27.0 0.1 3.6e-06 26.6 0.1 1.2 1 0 0 1 1 1 1 Phosphoenolpyruvate phosphomutase Nuc_rec_co-act PF08815.10 ETO25178.1 - 0.021 14.6 0.3 0.039 13.8 0.3 1.4 1 0 0 1 1 1 0 Nuclear receptor coactivator DUF1249 PF06853.12 ETO25179.1 - 0.056 13.5 0.2 2.7 8.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1249) OAD_gamma PF04277.13 ETO25179.1 - 3.1 8.4 4.8 2.1 9.0 2.1 2.0 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain HYR PF02494.16 ETO25181.1 - 0.0068 16.7 0.1 0.028 14.7 0.0 1.9 2 0 0 2 2 2 1 HYR domain MtrA PF04208.14 ETO25181.1 - 0.0068 16.1 0.1 0.013 15.1 0.1 1.5 1 1 0 1 1 1 1 Tetrahydromethanopterin S-methyltransferase, subunit A Herpes_IE2_3 PF03361.14 ETO25181.1 - 0.05 13.5 0.3 0.075 12.9 0.3 1.3 1 1 0 1 1 1 0 Herpes virus intermediate/early protein 2/3 Pox_A21 PF05323.12 ETO25181.1 - 0.099 13.2 0.0 0.17 12.5 0.0 1.5 1 0 0 1 1 1 0 Poxvirus A21 Protein TPR_12 PF13424.6 ETO25183.1 - 4e-30 103.9 6.6 5.3e-16 58.7 0.4 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO25183.1 - 2.3e-19 67.9 1.1 3.3e-06 26.7 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO25183.1 - 1.5e-18 66.0 0.0 8.3e-07 28.7 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO25183.1 - 2.6e-18 65.0 24.7 9.3e-08 31.6 0.7 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO25183.1 - 1e-17 62.7 16.3 2.5e-06 27.2 0.3 5.9 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO25183.1 - 2.3e-10 39.8 18.8 0.00088 19.3 0.3 5.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO25183.1 - 7.6e-07 29.7 0.0 0.094 13.4 0.0 3.8 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO25183.1 - 5.5e-06 26.4 0.4 0.09 13.2 0.1 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO25183.1 - 0.00011 21.7 10.3 0.044 13.5 0.2 4.4 4 1 1 5 5 5 2 TPR repeat TPR_6 PF13174.6 ETO25183.1 - 0.00021 21.7 0.6 5.7 7.8 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 ETO25183.1 - 0.00024 21.1 5.1 0.13 12.3 0.1 4.4 4 1 1 5 5 4 1 MIT (microtubule interacting and transport) domain Kelch_6 PF13964.6 ETO25183.1 - 0.00027 21.1 5.1 1.4 9.3 0.0 4.3 4 1 1 5 5 4 2 Kelch motif SHNi-TPR PF10516.9 ETO25183.1 - 0.00046 19.6 0.1 1.5 8.3 0.0 3.4 3 0 0 3 3 3 1 SHNi-TPR Kelch_1 PF01344.25 ETO25183.1 - 0.0021 17.6 8.8 0.59 9.8 0.2 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO25183.1 - 0.0026 17.7 0.8 12 6.1 0.1 4.2 5 0 0 5 5 4 0 Kelch motif DUF5113 PF17140.4 ETO25183.1 - 0.003 17.4 11.4 1.1 9.1 0.2 3.8 4 0 0 4 4 4 2 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO25183.1 - 0.005 16.8 18.5 0.82 9.7 0.3 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO25183.1 - 0.0057 17.1 0.1 0.029 14.9 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Vfa1 PF08432.10 ETO25183.1 - 0.0077 16.6 3.9 0.017 15.5 3.9 1.5 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Kelch_2 PF07646.15 ETO25183.1 - 1.4 9.0 3.6 15 5.8 0.0 3.9 4 0 0 4 4 3 0 Kelch motif WD40 PF00400.32 ETO25184.1 - 1.4e-61 203.0 16.4 1.7e-10 41.3 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25184.1 - 6.6e-25 87.2 5.1 0.0074 16.6 0.0 7.0 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25184.1 - 2.5e-15 56.3 0.3 0.032 13.2 0.0 6.8 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO25184.1 - 1.5e-13 51.0 2.2 3.1e-05 23.9 0.0 4.0 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO25184.1 - 8.4e-13 47.8 2.9 0.034 12.8 0.1 4.3 2 2 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO25184.1 - 6e-11 42.2 3.3 6.8e-07 28.9 0.1 3.5 1 1 4 5 5 5 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO25184.1 - 1.6e-09 36.8 1.3 0.016 13.8 0.1 3.9 2 1 2 4 4 4 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO25184.1 - 9.8e-06 24.6 5.2 0.061 12.1 0.7 4.0 1 1 1 3 3 3 3 Nup133 N terminal like PQQ PF01011.21 ETO25184.1 - 0.0038 17.1 0.0 8.8 6.5 0.0 3.8 4 0 0 4 4 4 1 PQQ enzyme repeat Str_synth PF03088.16 ETO25184.1 - 0.02 15.0 0.3 13 6.0 0.0 3.5 3 1 2 5 5 5 0 Strictosidine synthase PD40 PF07676.12 ETO25184.1 - 0.023 14.6 2.8 41 4.3 0.0 4.7 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat ChapFlgA PF13144.6 ETO25184.1 - 0.037 14.1 0.2 7 6.7 0.0 3.0 2 1 0 2 2 2 0 Chaperone for flagella basal body P-ring formation YTH PF04146.15 ETO25184.1 - 0.049 13.6 0.1 0.85 9.5 0.0 2.5 2 1 0 2 2 2 0 YT521-B-like domain Utp8 PF10395.9 ETO25184.1 - 0.098 11.1 3.0 1 7.8 0.6 2.6 1 1 2 3 3 3 0 Utp8 family DUF2963 PF11178.8 ETO25184.1 - 5 6.9 9.3 10 6.0 0.1 5.3 5 1 1 6 6 6 0 Protein of unknown function (DUF2963) Kelch_6 PF13964.6 ETO25185.1 - 2.1e-11 43.7 6.2 7.8e-06 26.0 1.7 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO25185.1 - 2.9e-09 36.5 2.5 0.00057 19.8 0.2 4.7 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETO25185.1 - 3.5e-08 33.3 0.4 4.9e-05 23.2 0.2 3.6 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO25185.1 - 1.3e-07 31.4 6.4 0.014 15.4 3.8 5.2 5 1 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO25185.1 - 6.6e-05 22.4 8.1 0.0024 17.4 0.6 4.1 5 0 0 5 5 5 1 Kelch motif DUF4105 PF13387.6 ETO25185.1 - 0.049 13.3 0.0 0.88 9.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4105) Kelch_3 PF13415.6 ETO25185.1 - 0.06 13.7 0.7 2.5 8.5 0.0 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain DUF5051 PF16473.5 ETO25186.1 - 0.02 14.9 0.4 2 8.4 0.0 2.4 2 0 0 2 2 2 0 3' exoribonuclease, RNase T-like TMEM151 PF14857.6 ETO25187.1 - 1.7e-09 37.1 0.2 2.4e-09 36.7 0.2 1.1 1 0 0 1 1 1 1 TMEM151 family TMEM151 PF14857.6 ETO25188.1 - 0.05 12.5 1.4 3.3 6.5 0.1 2.7 3 0 0 3 3 3 0 TMEM151 family RGS PF00615.19 ETO25190.1 - 1e-09 38.7 0.1 2e-09 37.7 0.1 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain AF-4 PF05110.13 ETO25191.1 - 0.44 8.6 15.3 0.64 8.0 15.3 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4052 PF13261.6 ETO25192.1 - 0.019 14.8 0.5 0.11 12.3 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4052) Gly_transf_sug PF04488.15 ETO25192.1 - 0.071 13.7 0.0 0.14 12.8 0.0 1.6 1 1 0 1 1 1 0 Glycosyltransferase sugar-binding region containing DXD motif Kelch_1 PF01344.25 ETO25194.1 - 5.3e-06 25.9 5.1 0.062 12.9 1.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO25194.1 - 0.00011 22.0 5.2 0.017 15.1 0.3 4.1 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO25194.1 - 0.00033 20.6 1.1 0.0064 16.5 0.0 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO25194.1 - 0.00039 20.6 0.0 0.018 15.3 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO25194.1 - 0.0057 16.9 3.4 0.71 10.2 0.1 3.6 4 0 0 4 4 4 1 Kelch motif SLC12 PF03522.15 ETO25194.1 - 0.064 12.3 0.5 8.8 5.2 0.3 2.1 2 0 0 2 2 2 0 Solute carrier family 12 Kelch_5 PF13854.6 ETO25194.1 - 5.7 7.0 8.9 61 3.7 0.0 4.7 6 0 0 6 6 6 0 Kelch motif XK-related PF09815.9 ETO25195.1 - 0.032 13.3 2.4 0.09 11.8 0.1 2.3 3 0 0 3 3 3 0 XK-related protein Menin PF05053.13 ETO25195.1 - 8.9 4.5 17.2 2.8 6.2 3.4 2.1 2 0 0 2 2 2 0 Menin zf-C3HC4_3 PF13920.6 ETO25198.1 - 1.2e-08 34.7 10.3 2.3e-08 33.8 10.3 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO25198.1 - 0.00024 21.4 9.5 0.00048 20.4 9.5 1.5 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ETO25198.1 - 0.018 15.0 10.7 0.037 14.0 10.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain CDC27 PF09507.10 ETO25198.1 - 0.019 14.4 23.8 0.024 14.0 23.8 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SDA1 PF05285.12 ETO25198.1 - 0.11 11.9 22.4 0.15 11.4 22.4 1.3 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO25198.1 - 0.12 10.5 22.3 0.14 10.3 22.3 1.1 1 0 0 1 1 1 0 Nop14-like family zf-C3HC4_2 PF13923.6 ETO25198.1 - 0.3 11.0 10.3 0.56 10.1 10.3 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) RR_TM4-6 PF06459.12 ETO25198.1 - 0.36 10.6 16.4 0.59 9.9 16.4 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-C3HC4 PF00097.25 ETO25198.1 - 0.83 9.6 10.1 2.6 8.0 10.1 1.9 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Trypan_PARP PF05887.11 ETO25198.1 - 1.3 9.0 15.7 2.6 8.0 15.7 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PTPRCAP PF15713.5 ETO25198.1 - 1.9 8.8 20.8 3.5 7.9 20.8 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF1682 PF07946.14 ETO25198.1 - 2.2 7.4 14.6 2.9 7.0 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) CobT PF06213.12 ETO25198.1 - 4.4 6.6 25.1 7.1 5.9 25.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 ETO25198.1 - 5 6.2 7.0 6.4 5.9 7.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter PGA2 PF07543.12 ETO25198.1 - 5.3 7.0 19.6 12 5.9 19.6 1.6 1 0 0 1 1 1 0 Protein trafficking PGA2 SOG2 PF10428.9 ETO25199.1 - 0.1 11.8 7.5 0.13 11.4 7.5 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF755 PF05501.11 ETO25200.1 - 0.9 9.8 7.5 0.4 11.0 2.1 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF755) Arf PF00025.21 ETO25202.1 - 2e-06 27.4 0.0 5.4e-06 26.0 0.0 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_16 PF13191.6 ETO25202.1 - 0.0014 19.0 0.9 0.0028 18.1 0.9 1.7 1 1 0 1 1 1 1 AAA ATPase domain Paf1 PF03985.13 ETO25202.1 - 0.0023 17.0 28.0 0.0028 16.7 28.0 1.0 1 0 0 1 1 1 1 Paf1 Allantoicase PF03561.15 ETO25202.1 - 0.06 13.3 4.2 1.8 8.5 4.2 2.1 1 1 0 1 1 1 0 Allantoicase repeat AAA_23 PF13476.6 ETO25202.1 - 0.23 12.0 28.4 0.52 10.8 28.4 1.5 1 1 0 1 1 1 0 AAA domain Presenilin PF01080.17 ETO25202.1 - 1.7 7.3 17.6 2.1 7.0 17.6 1.1 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETO25202.1 - 3 5.9 17.1 3.4 5.7 17.1 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4407 PF14362.6 ETO25202.1 - 3.6 6.8 10.4 4.8 6.4 10.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) WD40 PF00400.32 ETO25205.1 - 1.7e-06 28.6 0.0 1e-05 26.2 0.1 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO25205.1 - 0.038 12.6 0.0 0.038 12.6 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 NAD_binding_1 PF00175.21 ETO25206.1 - 1e-10 42.2 0.1 0.00043 20.9 0.0 2.4 1 1 1 2 2 2 2 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETO25206.1 - 2.5e-08 34.2 0.2 4.6e-08 33.3 0.2 1.4 1 0 0 1 1 1 1 Ferric reductase NAD binding domain EF-hand_9 PF14658.6 ETO25207.1 - 0.00028 21.2 0.0 0.69 10.3 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_6 PF13405.6 ETO25207.1 - 0.0016 18.2 0.1 6.2 7.0 0.0 3.6 3 1 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO25207.1 - 0.0056 16.2 0.0 6.1 6.6 0.0 3.7 3 0 0 3 3 3 1 EF hand ATG16 PF08614.11 ETO25208.1 - 0.0025 18.1 6.8 0.0031 17.8 6.8 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Nop14 PF04147.12 ETO25209.1 - 0.00028 19.3 15.8 0.00028 19.3 15.8 1.6 2 0 0 2 2 2 1 Nop14-like family Atrophin-1 PF03154.15 ETO25209.1 - 0.00094 17.6 31.5 0.0013 17.2 31.5 1.2 1 0 0 1 1 1 1 Atrophin-1 family SDA1 PF05285.12 ETO25209.1 - 0.13 11.6 31.8 0.22 10.9 31.8 1.5 1 1 0 1 1 1 0 SDA1 DUF3038 PF11237.8 ETO25209.1 - 0.42 10.6 3.7 0.91 9.5 3.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3038) BUD22 PF09073.10 ETO25209.1 - 4.7 6.4 29.2 0.013 14.9 18.9 1.8 2 0 0 2 2 2 0 BUD22 Amelotin PF15757.5 ETO25210.1 - 0.23 11.0 0.0 0.32 10.5 0.0 1.2 1 0 0 1 1 1 0 Amelotin Kelch_2 PF07646.15 ETO25211.1 - 2e-06 27.5 1.1 0.0016 18.4 0.3 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO25211.1 - 4.9e-05 22.8 1.4 0.0073 15.9 0.4 4.0 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO25211.1 - 0.001 19.3 0.8 3.3 8.2 0.3 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO25211.1 - 0.0095 15.9 0.7 0.3 11.1 0.1 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO25211.1 - 0.02 14.9 4.8 0.26 11.3 0.5 3.5 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO25211.1 - 0.04 14.2 0.0 0.63 10.4 0.0 3.0 4 0 0 4 4 4 0 Galactose oxidase, central domain WD40 PF00400.32 ETO25213.1 - 2.1e-28 98.0 20.5 6.8e-06 26.7 0.1 6.0 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25213.1 - 7.2e-10 39.0 1.1 0.18 12.2 0.0 5.7 3 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO25213.1 - 7e-08 31.6 2.8 0.085 11.5 0.0 4.2 2 1 2 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO25213.1 - 1.2e-06 29.1 3.8 1.2e-06 29.1 3.8 4.4 3 1 3 6 6 6 1 TRAF-type zinc finger Fez1 PF06818.15 ETO25213.1 - 2.4 8.6 32.9 0.17 12.3 8.6 2.7 1 1 1 2 2 2 0 Fez1 DUF4164 PF13747.6 ETO25213.1 - 6.7 7.1 12.6 24 5.3 4.7 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) DUF4470 PF14737.6 ETO25214.1 - 0.0033 17.6 1.9 0.019 15.1 0.2 2.3 1 1 1 2 2 2 1 Domain of unknown function (DUF4470) RRM_1 PF00076.22 ETO25215.1 - 2e-08 33.9 0.0 7e-08 32.2 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf_CCCH_4 PF18345.1 ETO25215.1 - 3.6e-07 30.0 3.3 6.8e-07 29.1 3.3 1.5 1 0 0 1 1 1 1 Zinc finger domain Torus PF16131.5 ETO25215.1 - 1.4e-06 28.9 1.6 1.9e-06 28.5 0.1 2.0 2 0 0 2 2 2 1 Torus domain zf-CCCH_3 PF15663.5 ETO25215.1 - 0.00035 20.8 0.2 0.00076 19.7 0.2 1.5 1 0 0 1 1 1 1 Zinc-finger containing family zf-CCCH PF00642.24 ETO25215.1 - 0.00078 19.3 2.1 0.0014 18.5 2.1 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Vfa1 PF08432.10 ETO25215.1 - 0.04 14.3 1.3 0.062 13.6 1.3 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 zf-CCCH_2 PF14608.6 ETO25215.1 - 0.063 13.8 1.8 0.12 12.9 1.8 1.5 1 0 0 1 1 1 0 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ETO25215.1 - 0.068 13.0 3.5 0.12 12.2 3.5 1.4 1 0 0 1 1 1 0 CCCH-type zinc finger Cyt-b5 PF00173.28 ETO25216.1 - 1.3e-08 34.9 0.1 1.8e-08 34.4 0.1 1.2 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain DUF5535 PF17687.1 ETO25216.1 - 0.02 15.0 0.0 0.03 14.5 0.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5535) MMS19_N PF14500.6 ETO25216.1 - 0.16 11.5 0.0 7.4 6.1 0.0 2.0 1 1 0 2 2 2 0 Dos2-interacting transcription regulator of RNA-Pol-II ABC2_membrane_3 PF12698.7 ETO25217.1 - 2.2e-13 50.1 12.9 3e-13 49.6 12.9 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF2070 PF09843.9 ETO25217.1 - 0.68 8.2 10.4 0.96 7.7 10.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Adap_comp_sub PF00928.21 ETO25219.1 - 1.2e-13 51.0 0.6 2.9e-08 33.4 0.1 2.2 2 0 0 2 2 2 2 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETO25219.1 - 1.9e-05 24.6 3.6 5.4e-05 23.2 2.2 2.4 2 1 0 2 2 2 1 Clathrin adaptor complex small chain Calcyon PF06387.11 ETO25219.1 - 0.013 15.5 0.1 0.026 14.5 0.1 1.5 1 0 0 1 1 1 0 D1 dopamine receptor-interacting protein (calcyon) Adap_comp_sub PF00928.21 ETO25220.1 - 3.3e-50 170.9 0.2 3.7e-50 170.8 0.2 1.0 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Lipase_3 PF01764.25 ETO25221.1 - 5.3e-12 45.8 0.0 1.5e-11 44.3 0.0 1.8 2 0 0 2 2 2 1 Lipase (class 3) Corazonin PF17308.2 ETO25221.1 - 4.9 7.5 11.1 0.55 10.6 3.4 2.9 3 0 0 3 3 3 0 Pro-corazonin Kelch_5 PF13854.6 ETO25222.1 - 2.1e-07 30.8 3.5 0.057 13.4 1.7 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO25222.1 - 3.3e-07 30.4 1.5 0.068 13.5 0.4 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO25222.1 - 0.00012 22.3 1.2 0.0093 16.2 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO25222.1 - 0.00029 20.4 3.4 0.13 11.9 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO25222.1 - 0.00047 20.0 0.9 0.16 12.0 0.0 3.4 3 0 0 3 3 3 1 Kelch motif SAS-6_N PF16531.5 ETO25222.1 - 0.032 14.8 0.6 0.089 13.4 0.6 1.8 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal Kelch_4 PF13418.6 ETO25222.1 - 0.057 13.4 0.9 1.6 8.8 0.1 2.9 2 0 0 2 2 2 0 Galactose oxidase, central domain RSN1_7TM PF02714.15 ETO25223.1 - 1.9e-21 76.6 12.2 6.6e-21 74.8 12.2 1.7 1 1 0 1 1 1 1 Calcium-dependent channel, 7TM region, putative phosphate WWE PF02825.20 ETO25225.1 - 4.2e-05 24.1 0.2 0.00018 22.1 0.2 2.1 1 0 0 1 1 1 1 WWE domain Pesticin PF16754.5 ETO25226.1 - 0.0006 19.8 0.0 0.0015 18.5 0.0 1.6 1 0 0 1 1 1 1 Bacterial toxin homologue of phage lysozyme, C-term Hamartin PF04388.12 ETO25226.1 - 0.31 9.7 18.9 0.37 9.4 18.9 1.3 1 0 0 1 1 1 0 Hamartin protein Tae4 PF14113.6 ETO25226.1 - 3.5 7.9 7.2 2.2e+02 2.1 7.2 2.7 1 1 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 COPI_C PF06957.11 ETO25226.1 - 7.6 5.2 15.7 7.3 5.2 8.0 2.3 1 1 1 2 2 2 0 Coatomer (COPI) alpha subunit C-terminus ChaB PF06150.12 ETO25226.1 - 8.4 7.1 8.9 0.69 10.5 0.2 3.3 4 0 0 4 4 4 0 ChaB Serglycin PF04360.12 ETO25227.1 - 0.023 14.7 1.6 0.023 14.7 1.6 1.6 2 0 0 2 2 2 0 Serglycin CCDC53 PF10152.9 ETO25228.1 - 4.3e-11 43.4 0.1 4.3e-11 43.4 0.1 1.7 2 1 0 2 2 2 1 Subunit CCDC53 of WASH complex TatD_DNase PF01026.21 ETO25229.1 - 1e-51 175.8 0.0 1.5e-51 175.3 0.0 1.2 1 0 0 1 1 1 1 TatD related DNase SNARE_assoc PF09335.11 ETO25230.1 - 8e-10 39.2 4.3 8e-10 39.2 4.3 2.2 2 0 0 2 2 2 1 SNARE associated Golgi protein SP_C-Propep PF08999.10 ETO25230.1 - 4.8 7.0 10.1 0.07 12.9 1.2 2.5 3 0 0 3 3 3 0 Surfactant protein C, N terminal propeptide TatD_DNase PF01026.21 ETO25231.1 - 1.1e-52 178.9 0.0 1.3e-52 178.7 0.0 1.0 1 0 0 1 1 1 1 TatD related DNase Amidohydro_2 PF04909.14 ETO25231.1 - 0.13 12.1 0.0 0.36 10.6 0.0 1.9 1 1 0 1 1 1 0 Amidohydrolase Glyco_transf_28 PF03033.20 ETO25232.1 - 0.068 13.2 0.1 0.27 11.3 0.1 1.8 1 1 1 2 2 2 0 Glycosyltransferase family 28 N-terminal domain OSR1_C PF12202.8 ETO25232.1 - 0.16 12.2 0.8 0.34 11.1 0.8 1.5 1 0 0 1 1 1 0 Oxidative-stress-responsive kinase 1 C-terminal domain Kelch_6 PF13964.6 ETO25233.1 - 6.4e-10 39.0 2.7 2.4e-05 24.4 0.5 4.2 3 1 1 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO25233.1 - 1.4e-07 31.4 0.1 7.9e-07 29.0 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO25233.1 - 8e-07 28.5 2.6 1.4e-05 24.6 0.2 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO25233.1 - 2.7e-06 27.5 0.1 0.00015 21.9 0.1 3.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO25233.1 - 8.6e-06 25.6 1.7 0.0033 17.4 2.5 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO25233.1 - 3.4e-05 23.7 0.7 0.067 13.2 0.3 4.3 4 0 0 4 4 4 1 Kelch motif BTB PF00651.31 ETO25234.1 - 1.1e-05 25.7 0.9 1.1e-05 25.7 0.9 1.9 2 1 0 2 2 2 1 BTB/POZ domain DUF3342 PF11822.8 ETO25234.1 - 0.065 13.4 0.6 0.19 12.0 0.6 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) Ras PF00071.22 ETO25235.1 - 1.4e-26 93.0 0.0 1.6e-26 92.8 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO25235.1 - 2.8e-15 56.6 0.0 4.1e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 ETO25235.1 - 4.2e-07 29.7 0.1 0.00011 21.8 0.1 2.2 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETO25235.1 - 1.9e-05 24.2 0.0 4.4e-05 23.0 0.0 1.5 2 0 0 2 2 2 1 Signal recognition particle receptor beta subunit Arf PF00025.21 ETO25235.1 - 6.7e-05 22.4 0.0 8.9e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO25235.1 - 0.0011 18.4 0.0 0.0012 18.2 0.0 1.2 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO25235.1 - 0.01 15.9 0.0 0.014 15.4 0.0 1.4 1 0 0 1 1 1 0 50S ribosome-binding GTPase PduV-EutP PF10662.9 ETO25235.1 - 0.037 13.8 0.0 0.07 12.9 0.0 1.6 1 1 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation DLIC PF05783.11 ETO25235.1 - 0.04 12.8 4.7 1.4 7.6 0.0 2.1 1 1 1 2 2 2 0 Dynein light intermediate chain (DLIC) G-alpha PF00503.20 ETO25235.1 - 0.052 12.7 0.2 0.093 11.9 0.1 1.5 1 1 0 1 1 1 0 G-protein alpha subunit ATP_bind_1 PF03029.17 ETO25235.1 - 0.057 13.2 0.0 0.22 11.3 0.0 1.8 1 1 1 2 2 2 0 Conserved hypothetical ATP binding protein CheR PF01739.18 ETO25235.1 - 0.094 12.2 0.3 0.13 11.7 0.3 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain MobB PF03205.14 ETO25235.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.5 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B WD40 PF00400.32 ETO25236.1 - 1.2e-36 124.1 24.0 4.5e-07 30.5 0.5 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25236.1 - 1.2e-12 47.9 7.6 0.0077 16.5 0.1 5.7 4 2 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO25236.1 - 5.7e-11 42.3 9.3 1.3e-05 24.7 3.9 3.7 2 2 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO25236.1 - 5.4e-09 35.2 7.7 0.052 12.2 0.0 5.3 2 2 3 5 5 5 5 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO25236.1 - 0.00048 20.1 3.1 0.012 15.6 0.2 3.9 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Aegerolysin PF06355.13 ETO25236.1 - 0.0056 16.8 1.3 0.0056 16.8 1.3 2.2 2 0 0 2 2 2 1 Aegerolysin LydB PF16084.5 ETO25236.1 - 0.011 15.6 0.0 0.03 14.2 0.0 1.7 1 1 0 1 1 1 0 LydA-holin antagonist DUF1664 PF07889.12 ETO25238.1 - 0.99 9.5 6.1 1.1 9.3 5.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF4050 PF13259.6 ETO25239.1 - 0.00046 20.6 1.5 0.0015 18.9 1.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4050) RRM_1 PF00076.22 ETO25239.1 - 0.011 15.5 0.0 0.036 13.9 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MDFI PF15316.6 ETO25239.1 - 0.23 11.6 4.8 0.73 9.9 4.8 1.8 1 0 0 1 1 1 0 MyoD family inhibitor Spt20 PF12090.8 ETO25239.1 - 1.2 8.7 18.3 0.089 12.4 11.0 2.6 3 0 0 3 3 3 0 Spt20 family CENP-B_dimeris PF09026.10 ETO25240.1 - 0.46 10.9 24.7 1.8 9.0 7.2 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO25240.1 - 7.7 6.2 19.5 1.2 8.8 7.2 3.0 3 0 0 3 3 3 0 FAM176 family PH PF00169.29 ETO25241.1 - 0.046 14.2 0.0 0.1 13.1 0.0 1.5 1 0 0 1 1 1 0 PH domain RRM_1 PF00076.22 ETO25242.1 - 0.0012 18.6 0.2 3 7.7 0.0 3.0 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DEK_C PF08766.11 ETO25242.1 - 0.14 12.1 0.2 49 3.9 0.0 3.3 3 0 0 3 3 3 0 DEK C terminal domain SH3_1 PF00018.28 ETO25243.1 - 1.9e-08 33.8 0.1 8e-07 28.6 0.0 2.4 2 0 0 2 2 2 1 SH3 domain SH3_2 PF07653.17 ETO25243.1 - 0.00035 20.2 0.0 0.00083 19.0 0.0 1.6 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ETO25243.1 - 0.00073 19.3 0.1 0.0012 18.7 0.1 1.4 1 0 0 1 1 1 1 Variant SH3 domain Nup35_RRM PF05172.13 ETO25243.1 - 0.021 14.8 1.2 0.41 10.6 0.0 2.9 3 0 0 3 3 3 0 Nup53/35/40-type RNA recognition motif BP28CT PF08146.12 ETO25243.1 - 0.04 13.8 0.2 0.077 12.8 0.2 1.4 1 0 0 1 1 1 0 BP28CT (NUC211) domain DUF4227 PF14004.6 ETO25243.1 - 0.06 13.3 0.1 0.15 12.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4227) RRM_1 PF00076.22 ETO25243.1 - 0.073 12.9 0.0 0.24 11.3 0.0 1.8 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Sulfotransfer_2 PF03567.14 ETO25245.1 - 2.3e-14 53.9 1.5 2.3e-14 53.9 1.5 1.5 2 0 0 2 2 2 1 Sulfotransferase family DUF2892 PF11127.8 ETO25246.1 - 0.37 10.9 3.7 0.2 11.7 1.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) HMG_box PF00505.19 ETO25247.1 - 4.7e-22 78.2 7.7 4.7e-22 78.2 7.7 2.9 2 1 1 3 3 3 1 HMG (high mobility group) box HMG_box_2 PF09011.10 ETO25247.1 - 6e-15 55.6 5.9 6e-15 55.6 5.9 3.1 3 1 0 3 3 3 1 HMG-box domain Dus PF01207.17 ETO25247.1 - 1.6 7.7 5.7 2.3 7.2 5.7 1.2 1 0 0 1 1 1 0 Dihydrouridine synthase (Dus) Nucleo_P87 PF07267.11 ETO25247.1 - 2.7 6.7 19.8 2.9 6.7 19.8 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 MID_MedPIWI PF18296.1 ETO25247.1 - 6.3 6.5 16.0 8.5 6.1 16.0 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Presenilin PF01080.17 ETO25247.1 - 9.9 4.8 21.1 9.7 4.8 21.1 1.2 1 0 0 1 1 1 0 Presenilin IDH PF03971.14 ETO25249.1 - 0.18 10.3 0.0 0.23 9.9 0.0 1.1 1 0 0 1 1 1 0 Monomeric isocitrate dehydrogenase HEAT PF02985.22 ETO25250.1 - 1.8e-08 33.9 1.4 0.64 10.4 0.0 4.7 4 1 0 4 4 4 3 HEAT repeat HEAT_2 PF13646.6 ETO25250.1 - 0.0017 18.7 0.8 0.17 12.3 0.2 2.9 2 1 1 3 3 3 2 HEAT repeats CLASP_N PF12348.8 ETO25250.1 - 0.0023 17.5 0.2 0.0048 16.5 0.2 1.5 1 0 0 1 1 1 1 CLASP N terminal CBF PF03914.17 ETO25250.1 - 0.028 14.5 0.5 0.55 10.2 0.5 2.2 1 1 0 1 1 1 0 CBF/Mak21 family DAGAT PF03982.13 ETO25251.1 - 4.1e-23 81.8 0.3 7.6e-18 64.4 0.1 2.1 2 0 0 2 2 2 2 Diacylglycerol acyltransferase Toxin_8 PF07365.12 ETO25251.1 - 0.37 11.0 1.6 0.66 10.2 1.6 1.4 1 0 0 1 1 1 0 Alpha conotoxin precursor WD40 PF00400.32 ETO25252.1 - 3.9e-47 157.2 30.5 1.6e-07 31.9 1.5 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25252.1 - 6.4e-18 64.9 4.4 0.00089 19.5 0.0 6.0 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO25252.1 - 2.8e-12 46.1 8.2 0.00074 18.3 0.3 5.9 1 1 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO25252.1 - 3.8e-08 33.0 8.9 0.019 14.3 0.1 5.1 3 1 2 5 5 5 4 WD40-like domain PI3K_C2 PF00792.24 ETO25252.1 - 0.0091 15.9 0.1 0.058 13.3 0.1 2.3 2 0 0 2 2 2 1 Phosphoinositide 3-kinase C2 DUF4979 PF16351.5 ETO25252.1 - 0.2 11.9 6.8 5.9 7.1 0.2 3.8 2 1 2 4 4 4 0 Domain of unknown function (DUF4979) Pyr_redox_3 PF13738.6 ETO25253.1 - 3.7e-14 52.7 0.0 3.3e-12 46.3 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase FMO-like PF00743.19 ETO25253.1 - 6e-14 51.4 0.0 1.3e-12 47.0 0.0 2.0 2 0 0 2 2 2 1 Flavin-binding monooxygenase-like Pyr_redox_2 PF07992.14 ETO25253.1 - 1.9e-09 37.2 0.0 1.4e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO25253.1 - 5.7e-06 25.7 0.0 0.00012 21.4 0.0 2.1 2 0 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) Pyr_redox PF00070.27 ETO25253.1 - 0.0039 17.7 0.0 0.0082 16.7 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETO25253.1 - 0.0077 15.3 0.1 0.67 9.0 0.0 2.6 3 0 0 3 3 3 1 Glucose inhibited division protein A ThiF PF00899.21 ETO25253.1 - 0.0085 15.5 0.0 0.0085 15.5 0.0 2.2 2 0 0 2 2 2 1 ThiF family NAD_binding_7 PF13241.6 ETO25253.1 - 0.034 14.6 0.0 0.075 13.5 0.0 1.8 1 1 0 1 1 1 0 Putative NAD(P)-binding Shikimate_DH PF01488.20 ETO25253.1 - 0.056 13.5 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ETO25253.1 - 0.092 12.4 0.0 0.23 11.1 0.0 1.7 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Secretin_N_2 PF07655.13 ETO25253.1 - 2.2 8.9 18.8 4.1 8.0 18.8 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Orf78 PF06024.12 ETO25253.1 - 2.5 8.4 8.2 4.6 7.6 8.2 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Menin PF05053.13 ETO25253.1 - 3.9 5.7 8.5 5.1 5.3 8.5 1.1 1 0 0 1 1 1 0 Menin Deltaretro_Tax PF05599.11 ETO25254.1 - 0.14 12.7 0.0 0.77 10.3 0.0 2.2 3 0 0 3 3 3 0 Deltaretrovirus Tax protein BSP_II PF05432.11 ETO25254.1 - 0.25 11.0 19.7 0.49 10.0 19.7 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) BUD22 PF09073.10 ETO25254.1 - 3 7.1 26.3 5.9 6.1 26.3 1.4 1 0 0 1 1 1 0 BUD22 RRM_1 PF00076.22 ETO25255.1 - 2.3e-06 27.3 0.0 1.8e-05 24.5 0.0 2.2 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC PF00098.23 ETO25255.1 - 1.9e-05 24.5 2.5 1.9e-05 24.5 2.5 1.9 2 0 0 2 2 2 1 Zinc knuckle zf-CCHC_4 PF14392.6 ETO25255.1 - 0.00056 19.6 0.7 0.0012 18.6 0.7 1.6 1 0 0 1 1 1 1 Zinc knuckle RRM_5 PF13893.6 ETO25255.1 - 0.0011 18.6 0.0 0.0049 16.5 0.0 1.9 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) zf-CCHC_6 PF15288.6 ETO25255.1 - 0.0036 17.1 1.9 0.0036 17.1 1.9 2.2 2 0 0 2 2 2 1 Zinc knuckle Pox_Ag35 PF03286.14 ETO25255.1 - 0.0077 16.0 2.7 0.012 15.4 2.7 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein zf-RanBP PF00641.18 ETO25255.1 - 0.0091 15.3 14.2 0.0091 15.3 14.2 1.7 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others MRP-L46 PF11788.8 ETO25255.1 - 0.087 13.6 2.5 0.2 12.4 2.5 1.5 1 0 0 1 1 1 0 39S mitochondrial ribosomal protein L46 Folate_carrier PF01770.18 ETO25255.1 - 0.25 10.1 0.8 0.39 9.4 0.8 1.2 1 0 0 1 1 1 0 Reduced folate carrier zf-Paramyx-P PF13008.7 ETO25255.1 - 4.5 6.8 14.8 0.8 9.2 7.7 2.3 2 0 0 2 2 2 0 Zinc-binding domain of Paramyxoviridae V protein zf-RanBP PF00641.18 ETO25256.1 - 4.2e-05 22.8 6.0 7.6e-05 21.9 6.0 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others ALMT PF11744.8 ETO25256.1 - 1.5 7.5 10.7 1.9 7.2 10.7 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Na_trans_assoc PF06512.13 ETO25257.1 - 0.17 12.1 5.3 0.2 11.9 5.3 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Nipped-B_C PF12830.7 ETO25258.1 - 3.7e-11 43.3 0.1 2.7e-10 40.5 0.0 2.4 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Peptidase_C48 PF02902.19 ETO25259.1 - 3.9e-30 105.3 7.0 3.9e-30 105.3 7.0 2.5 3 0 0 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain LupA PF18242.1 ETO25259.1 - 0.0057 16.3 0.1 0.011 15.4 0.1 1.4 1 0 0 1 1 1 1 Legionella ubiquitin-specific protease A domain Cohesin_HEAT PF12765.7 ETO25260.1 - 1.8e-09 37.7 2.4 4.4e-07 30.1 0.7 2.3 2 0 0 2 2 2 2 HEAT repeat associated with sister chromatid cohesion Cnd1 PF12717.7 ETO25260.1 - 0.0011 19.1 1.1 0.0066 16.5 0.3 2.2 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO25260.1 - 0.0027 17.8 0.1 0.4 11.1 0.0 3.2 3 0 0 3 3 3 1 HEAT repeat RasGEF_N_2 PF14663.6 ETO25260.1 - 0.13 12.7 1.0 6.9 7.1 0.1 3.1 2 1 1 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain WD40 PF00400.32 ETO25262.1 - 6.2e-29 99.6 14.7 5.3e-09 36.6 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25262.1 - 7.6e-05 22.9 0.0 0.83 10.0 0.0 4.1 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO25262.1 - 0.0032 16.8 0.2 0.087 12.1 0.1 2.8 1 1 1 3 3 3 1 WD40-like domain AAA PF00004.29 ETO25264.1 - 9.1e-42 142.6 0.0 1.3e-41 142.1 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO25264.1 - 1.1e-07 31.8 0.0 2.4e-07 30.6 0.0 1.6 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETO25264.1 - 3.4e-07 30.8 0.6 2.6e-06 27.9 0.3 2.3 1 1 1 2 2 2 1 AAA ATPase domain AAA_2 PF07724.14 ETO25264.1 - 4.2e-06 27.0 0.0 1e-05 25.7 0.0 1.8 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ETO25264.1 - 6.2e-06 26.4 0.0 1.1e-05 25.7 0.0 1.5 1 1 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO25264.1 - 3.1e-05 24.5 0.1 0.00026 21.5 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO25264.1 - 8.1e-05 22.9 0.3 0.0072 16.6 0.0 2.4 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO25264.1 - 9.7e-05 22.4 0.6 0.0011 18.9 0.6 2.5 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ETO25264.1 - 0.00033 20.5 0.0 0.00058 19.6 0.0 1.5 1 0 0 1 1 1 1 IstB-like ATP binding protein TIP49 PF06068.13 ETO25264.1 - 0.0014 18.0 0.1 0.0045 16.3 0.0 1.7 1 1 0 2 2 2 1 TIP49 P-loop domain NACHT PF05729.12 ETO25264.1 - 0.0029 17.5 0.2 0.03 14.2 0.0 2.1 1 1 1 2 2 2 1 NACHT domain Mg_chelatase PF01078.21 ETO25264.1 - 0.003 17.0 0.3 0.007 15.8 0.1 1.6 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ETO25264.1 - 0.0041 17.2 0.0 0.0086 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ETO25264.1 - 0.0054 16.0 1.3 0.098 11.9 0.1 3.0 3 1 0 3 3 3 1 Zeta toxin AAA_25 PF13481.6 ETO25264.1 - 0.011 15.3 1.3 0.41 10.2 0.1 2.4 1 1 1 2 2 2 0 AAA domain AAA_28 PF13521.6 ETO25264.1 - 0.012 15.8 0.0 0.028 14.7 0.0 1.5 1 1 0 1 1 1 0 AAA domain CPT PF07931.12 ETO25264.1 - 0.015 15.1 0.1 0.067 13.0 0.0 2.0 2 1 0 2 2 2 0 Chloramphenicol phosphotransferase-like protein TsaE PF02367.17 ETO25264.1 - 0.018 15.0 0.0 0.033 14.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ETO25264.1 - 0.024 14.2 0.0 0.12 11.9 0.0 2.1 1 1 0 1 1 1 0 P-loop containing dynein motor region RNA_helicase PF00910.22 ETO25264.1 - 0.034 14.5 0.4 0.079 13.4 0.0 2.0 2 1 0 2 2 1 0 RNA helicase ATPase PF06745.13 ETO25264.1 - 0.039 13.3 0.1 0.47 9.7 0.0 2.1 1 1 0 2 2 2 0 KaiC ABC_tran PF00005.27 ETO25264.1 - 0.039 14.5 0.2 0.13 12.7 0.1 2.0 1 1 0 2 2 2 0 ABC transporter AAA_17 PF13207.6 ETO25264.1 - 0.04 14.3 0.1 0.1 13.1 0.0 1.7 1 1 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ETO25264.1 - 0.046 13.0 0.1 0.097 11.9 0.1 1.7 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DEAD PF00270.29 ETO25264.1 - 0.06 13.1 0.0 7.9 6.2 0.0 2.2 2 0 0 2 2 2 0 DEAD/DEAH box helicase Hydin_ADK PF17213.3 ETO25264.1 - 0.067 13.5 0.0 0.15 12.4 0.0 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Viral_helicase1 PF01443.18 ETO25264.1 - 0.071 12.8 0.0 0.13 12.0 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase Rad17 PF03215.15 ETO25264.1 - 0.077 12.9 0.7 0.11 12.4 0.0 1.6 2 0 0 2 2 1 0 Rad17 P-loop domain AAA_3 PF07726.11 ETO25264.1 - 0.089 12.7 0.0 0.2 11.5 0.0 1.7 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_24 PF13479.6 ETO25264.1 - 0.11 12.2 0.0 0.32 10.7 0.0 1.8 1 1 0 1 1 1 0 AAA domain DAP3 PF10236.9 ETO25264.1 - 0.12 11.6 0.1 3.1 6.9 0.0 2.2 1 1 1 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 eIF2A PF08662.11 ETO25266.1 - 2.8e-48 164.4 0.0 3.7e-48 164.0 0.0 1.2 1 0 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A TFIIA PF03153.13 ETO25266.1 - 0.025 14.6 25.9 0.03 14.4 25.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Endostatin PF06482.11 ETO25266.1 - 2.8 7.3 21.5 21 4.4 21.5 2.0 1 1 0 1 1 1 0 Collagenase NC10 and Endostatin TLP-20 PF06088.11 ETO25266.1 - 8.8 6.2 16.6 0.047 13.6 6.0 2.0 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Noelin-1 PF12308.8 ETO25267.1 - 3.4 7.7 18.0 0.96 9.5 2.3 3.5 3 0 0 3 3 3 0 Neurogenesis glycoprotein EssA PF10661.9 ETO25268.1 - 0.019 14.8 6.7 0.021 14.6 6.7 1.1 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA UCH PF00443.29 ETO25270.1 - 1.8e-19 70.3 0.5 3.1e-19 69.5 0.5 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO25270.1 - 3.1e-10 40.2 5.3 1.2e-05 25.1 0.1 2.5 2 1 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase NinF PF05810.12 ETO25270.1 - 0.078 12.8 0.0 0.28 11.1 0.0 1.9 2 0 0 2 2 2 0 NinF protein DUF863 PF05904.11 ETO25271.1 - 0.17 10.3 1.9 0.2 10.0 1.9 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF863) CBM_3 PF00942.18 ETO25272.1 - 0.065 13.7 0.0 0.11 12.9 0.0 1.4 1 0 0 1 1 1 0 Cellulose binding domain RPAP3_C PF13877.6 ETO25272.1 - 0.068 13.7 0.0 0.5 10.9 0.0 2.1 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 IMS PF00817.20 ETO25273.1 - 2.9e-22 79.3 0.0 6.6e-22 78.1 0.0 1.6 1 0 0 1 1 1 1 impB/mucB/samB family IMS_C PF11799.8 ETO25273.1 - 1.6e-15 57.9 0.2 3.4e-15 56.8 0.2 1.5 1 0 0 1 1 1 1 impB/mucB/samB family C-terminal domain IMS_HHH PF11798.8 ETO25273.1 - 3.1e-07 30.3 0.1 7.9e-07 29.0 0.1 1.6 1 0 0 1 1 1 1 IMS family HHH motif DUF236 PF03057.14 ETO25273.1 - 0.025 14.6 0.0 0.048 13.6 0.0 1.4 1 0 0 1 1 1 0 DUF236 repeat TonB_N PF16031.5 ETO25273.1 - 0.067 13.7 3.6 0.12 12.8 3.6 1.4 1 0 0 1 1 1 0 TonB polyproline region BAF PF02961.14 ETO25273.1 - 0.09 13.2 0.4 1.1 9.8 0.0 2.8 2 0 0 2 2 2 0 Barrier to autointegration factor zf-ribbon_3 PF13248.6 ETO25273.1 - 3.4 7.2 5.2 24 4.5 0.3 2.5 2 0 0 2 2 2 0 zinc-ribbon domain Pkinase PF00069.25 ETO25274.1 - 1.7e-24 86.7 1.1 4e-11 42.8 0.0 4.0 1 1 3 4 4 4 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25274.1 - 2.8e-12 46.5 0.0 3.4e-10 39.7 0.0 2.4 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO25274.1 - 0.00053 19.4 0.0 0.00098 18.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO25274.1 - 0.055 13.4 0.0 1.2 9.0 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO25274.1 - 0.069 11.9 0.0 0.1 11.3 0.0 1.2 1 0 0 1 1 1 0 Fungal protein kinase SNase PF00565.17 ETO25275.1 - 6.8e-18 65.1 10.2 4.1e-13 49.7 0.4 4.2 4 1 0 4 4 4 3 Staphylococcal nuclease homologue PhaP_Bmeg PF09602.10 ETO25275.1 - 0.011 15.7 1.3 0.039 13.9 1.3 2.0 1 0 0 1 1 1 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) SNase PF00565.17 ETO25276.1 - 7.3e-19 68.2 6.9 1.8e-05 25.2 0.0 4.6 3 2 1 4 4 4 3 Staphylococcal nuclease homologue TUDOR PF00567.24 ETO25276.1 - 6.9e-18 64.8 0.0 1.8e-17 63.5 0.0 1.7 1 0 0 1 1 1 1 Tudor domain MYCBPAP PF14646.6 ETO25277.1 - 0.12 11.3 0.0 0.16 10.9 0.0 1.1 1 0 0 1 1 1 0 MYCBP-associated protein family Histone PF00125.24 ETO25278.1 - 2.2e-16 60.4 0.3 3.3e-16 59.8 0.3 1.3 1 0 0 1 1 1 1 Core histone H2A/H2B/H3/H4 CBFD_NFYB_HMF PF00808.23 ETO25278.1 - 0.005 17.1 0.1 0.005 17.1 0.1 2.4 3 0 0 3 3 3 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TFIID_20kDa PF03847.13 ETO25278.1 - 0.09 13.3 0.2 0.22 12.1 0.1 1.6 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A DAPG_hydrolase PF18089.1 ETO25279.1 - 2e-08 34.1 11.7 3.2e-08 33.4 11.7 1.3 1 0 0 1 1 1 1 DAPG hydrolase PhiG domain bacHORMA_2 PF18173.1 ETO25280.1 - 0.021 14.6 0.5 0.049 13.5 0.5 1.6 1 0 0 1 1 1 0 Bacterial HORMA domain 2 DUF4618 PF15397.6 ETO25280.1 - 0.031 13.7 2.0 0.05 13.0 2.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) SAM_PNT PF02198.16 ETO25280.1 - 0.036 14.0 0.1 0.079 12.9 0.1 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DHR10 PF18595.1 ETO25280.1 - 0.069 13.2 1.8 0.14 12.2 1.8 1.5 1 0 0 1 1 1 0 Designed helical repeat protein 10 domain Pkinase PF00069.25 ETO25281.1 - 7.5e-43 146.8 0.2 1.4e-41 142.6 0.2 2.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25281.1 - 2.4e-25 89.3 0.2 1.5e-19 70.3 0.0 2.8 2 1 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO25281.1 - 0.13 11.5 0.0 9.9 5.4 0.0 2.8 3 0 0 3 3 3 0 Kinase-like Mannosyl_trans3 PF11051.8 ETO25282.1 - 5e-06 26.1 0.0 7.2e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative CLIP PF12032.8 ETO25282.1 - 0.013 15.8 0.0 0.03 14.6 0.0 1.6 1 0 0 1 1 1 0 Regulatory CLIP domain of proteinases B56 PF01603.20 ETO25283.1 - 3e-36 125.3 2.3 3.6e-36 125.0 2.3 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DUF4776 PF16003.5 ETO25283.1 - 0.0081 15.2 0.2 0.0094 15.0 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4776) MRP-S35 PF10246.9 ETO25283.1 - 0.13 12.2 0.0 0.19 11.7 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein MRP-S35 Mlo PF03094.15 ETO25284.1 - 0.057 11.8 2.3 0.05 12.0 1.1 1.5 1 1 1 2 2 2 0 Mlo family Co_AT_N PF12557.8 ETO25284.1 - 0.41 10.6 4.1 1.4 8.9 4.1 2.0 1 0 0 1 1 1 0 Cob(I)alamin adenosyltransferase N terminal Kelch_6 PF13964.6 ETO25285.1 - 1.3e-06 28.4 4.6 0.0082 16.4 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO25285.1 - 0.0035 17.3 1.2 0.79 9.8 0.1 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO25285.1 - 0.054 13.5 8.7 3.8 7.6 0.4 4.3 4 0 0 4 4 4 0 Kelch motif Kelch_1 PF01344.25 ETO25285.1 - 0.056 13.0 6.7 5.1 6.8 0.0 4.0 5 0 0 5 5 5 0 Kelch motif Kelch_2 PF07646.15 ETO25285.1 - 0.45 10.6 4.4 24 5.1 0.1 4.2 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO25286.1 - 6e-55 182.0 18.0 3.8e-08 33.9 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25286.1 - 2.5e-16 59.7 4.1 0.038 14.3 0.0 6.3 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25286.1 - 2.6e-16 59.5 1.3 0.0052 15.8 0.0 6.2 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO25286.1 - 3.6e-10 40.0 1.4 0.001 19.0 0.0 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO25286.1 - 2e-08 33.9 3.2 1.8e-05 24.2 0.1 3.2 1 1 3 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO25286.1 - 8e-06 24.8 6.7 2.6 6.6 0.1 5.4 1 1 5 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO25286.1 - 1.4e-05 24.8 10.7 0.92 9.5 0.1 6.3 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO25286.1 - 0.0012 17.4 1.8 0.5 8.8 0.1 3.1 1 1 4 5 5 5 4 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO25286.1 - 0.0038 16.6 0.8 0.49 9.7 0.1 2.9 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO25286.1 - 0.0049 15.7 0.7 2.9 6.5 0.0 3.9 2 1 3 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF1513 PF07433.11 ETO25286.1 - 0.0093 15.1 0.1 7.3 5.6 0.0 3.5 1 1 1 4 4 4 1 Protein of unknown function (DUF1513) PALB2_WD40 PF16756.5 ETO25286.1 - 0.014 14.3 6.5 0.69 8.8 0.1 4.1 2 1 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Resistin PF06954.11 ETO25286.1 - 0.062 13.8 0.0 45 4.7 0.0 3.5 3 1 1 4 4 4 0 Resistin WD40 PF00400.32 ETO25287.1 - 2.9e-58 192.5 19.9 1e-11 45.2 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25287.1 - 2.4e-19 69.4 0.4 0.0092 16.3 0.0 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25287.1 - 1.9e-16 60.0 0.8 0.035 13.1 0.0 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO25287.1 - 6.2e-08 31.7 2.7 0.17 10.5 0.0 4.9 1 1 4 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO25287.1 - 6.8e-06 25.9 13.6 1.4 9.0 0.1 6.9 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO25287.1 - 1.3e-05 24.7 0.2 0.13 11.5 0.0 2.9 2 1 1 3 3 3 2 WD40-like domain Str_synth PF03088.16 ETO25287.1 - 0.00021 21.3 0.1 8 6.7 0.0 4.5 3 2 3 6 6 6 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO25287.1 - 0.0037 15.8 0.0 0.38 9.2 0.0 2.5 1 1 1 2 2 2 1 Cytochrome D1 heme domain HARP PF07443.13 ETO25287.1 - 0.013 15.1 0.1 2.4 7.9 0.0 3.7 4 0 0 4 4 4 0 HepA-related protein (HARP) Proteasome_A_N PF10584.9 ETO25287.1 - 0.055 13.2 19.0 1.4 8.6 0.0 6.7 8 0 0 8 8 8 0 Proteasome subunit A N-terminal signature SBD PF17882.1 ETO25287.1 - 0.078 12.8 0.0 0.5 10.2 0.0 2.2 2 0 0 2 2 2 0 OAA-family lectin sugar binding domain NodS PF05401.11 ETO25287.1 - 0.13 11.8 0.0 8.2 6.0 0.0 3.1 3 1 1 4 4 4 0 Nodulation protein S (NodS) MIF4G PF02854.19 ETO25289.1 - 2.7e-09 37.0 3.6 5.8e-09 35.9 3.6 1.6 1 1 0 1 1 1 1 MIF4G domain CNOT1_CAF1_bind PF16415.5 ETO25289.1 - 0.0013 18.1 0.3 0.0023 17.4 0.3 1.3 1 0 0 1 1 1 1 CCR4-NOT transcription complex subunit 1 CAF1-binding domain IMUP PF15761.5 ETO25289.1 - 3.1 8.5 9.4 15 6.3 1.0 2.5 2 0 0 2 2 2 0 Immortalisation up-regulated protein SAPIS-gp6 PF16722.5 ETO25290.1 - 0.19 12.2 4.7 6 7.4 0.7 3.0 2 0 0 2 2 2 0 Pathogenicity island protein gp6 in Staphylococcus THOC2_N PF16134.5 ETO25291.1 - 8e-18 64.4 8.3 4.8e-10 38.7 0.6 2.2 2 0 0 2 2 2 2 THO complex subunit 2 N-terminus Endonuclease_5 PF04493.14 ETO25292.1 - 1.3e-54 184.9 0.0 6.2e-52 176.2 0.0 2.6 1 1 0 1 1 1 1 Endonuclease V UvrC_HhH_N PF08459.11 ETO25292.1 - 0.00056 19.8 0.0 0.0021 18.0 0.0 2.0 1 1 0 1 1 1 1 UvrC Helix-hairpin-helix N-terminal Tho2 PF11262.8 ETO25293.1 - 1.1e-43 149.6 7.6 1.1e-43 149.6 7.6 3.4 2 1 1 3 3 3 1 Transcription factor/nuclear export subunit protein 2 FAM176 PF14851.6 ETO25293.1 - 0.026 14.2 0.7 0.026 14.2 0.7 5.2 4 1 2 6 6 6 0 FAM176 family DUF4510 PF14971.6 ETO25293.1 - 0.089 13.1 2.5 0.27 11.6 2.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4510) Sec23_trunk PF04811.15 ETO25294.1 - 1.6e-09 37.7 0.1 8.3e-09 35.4 0.1 2.1 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain VWA_2 PF13519.6 ETO25294.1 - 6.5e-05 23.5 0.0 0.029 15.0 0.0 2.7 1 1 0 1 1 1 1 von Willebrand factor type A domain dsRBD2 PF17842.1 ETO25294.1 - 0.11 12.7 1.6 0.43 10.8 1.6 2.0 1 1 0 1 1 1 0 Double-stranded RNA binding domain 2 zf-Sec23_Sec24 PF04810.15 ETO25295.1 - 0.00043 20.3 0.6 0.0014 18.6 0.6 2.0 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger AZUL PF16558.5 ETO25297.1 - 2.3e-14 53.4 1.1 6.2e-14 52.0 1.1 1.8 1 0 0 1 1 1 1 Amino-terminal Zinc-binding domain of ubiquitin ligase E3A PUB PF09409.10 ETO25297.1 - 0.0025 17.7 0.3 0.0066 16.4 0.3 1.6 1 0 0 1 1 1 1 PUB domain AAA PF00004.29 ETO25298.1 - 7.3e-05 23.2 1.6 0.00011 22.7 0.1 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO25298.1 - 0.0041 16.9 0.0 0.0074 16.0 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETO25298.1 - 0.0083 16.5 1.9 0.021 15.2 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_11 PF13086.6 ETO25298.1 - 1.2 8.9 0.0 1.2 8.9 0.0 4.6 2 1 1 3 3 3 0 AAA domain DUF962 PF06127.11 ETO25300.1 - 3.6e-23 81.5 2.2 1.2e-22 79.8 2.2 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF962) SbcCD_C PF13558.6 ETO25301.1 - 3.4e-06 27.2 0.0 9.2e-06 25.8 0.0 1.8 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ETO25301.1 - 0.00019 20.9 13.1 0.00019 20.9 13.1 1.9 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO25301.1 - 0.00024 21.0 0.2 0.00079 19.3 0.0 1.9 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system SKA2 PF16740.5 ETO25301.1 - 0.012 15.3 4.2 0.012 15.3 4.2 5.6 3 2 1 4 4 4 0 Spindle and kinetochore-associated protein 2 Lectin_C_term PF18022.1 ETO25301.1 - 0.052 14.0 0.0 0.28 11.7 0.0 2.3 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin C-terminal domain DUF3671 PF12420.8 ETO25301.1 - 0.052 13.6 1.3 0.21 11.7 1.3 2.1 1 0 0 1 1 1 0 Protein of unknown function Abi_C PF14355.6 ETO25301.1 - 0.44 10.7 5.0 6.2 7.0 0.1 3.8 3 1 1 4 4 4 0 Abortive infection C-terminus AAA_13 PF13166.6 ETO25301.1 - 1.4 7.5 61.3 0.35 9.5 30.2 3.4 2 2 0 2 2 2 0 AAA domain DUF4658 PF15555.6 ETO25301.1 - 3.2 7.9 5.1 3.3 7.8 0.0 3.2 4 0 0 4 4 4 0 Domain of unknown function (DUF4658) AAA_23 PF13476.6 ETO25302.1 - 2.4e-29 103.3 0.0 2.4e-29 103.3 0.0 4.5 3 2 1 4 4 2 1 AAA domain AAA_15 PF13175.6 ETO25302.1 - 5.4e-09 36.2 1.0 5.4e-09 36.2 1.0 3.6 1 1 2 3 3 1 1 AAA ATPase domain SMC_N PF02463.19 ETO25302.1 - 1.9e-08 34.0 0.0 1.9e-08 34.0 0.0 3.1 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO25302.1 - 2.9e-05 24.0 1.1 0.00016 21.6 0.0 2.7 3 1 0 3 3 3 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETO25302.1 - 0.0001 21.9 0.0 0.00025 20.7 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain Sec34 PF04136.15 ETO25302.1 - 0.0036 17.2 3.6 0.0036 17.2 3.6 6.2 4 1 3 7 7 7 3 Sec34-like family ABC_tran PF00005.27 ETO25302.1 - 0.016 15.7 0.0 0.016 15.7 0.0 4.3 2 1 0 2 2 1 0 ABC transporter AAA_28 PF13521.6 ETO25302.1 - 0.042 14.1 0.0 0.17 12.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO25302.1 - 0.15 12.4 4.1 0.17 12.3 0.0 2.9 3 2 0 3 3 3 0 AAA ATPase domain AAA_33 PF13671.6 ETO25302.1 - 0.39 10.9 0.0 0.39 10.9 0.0 2.7 3 0 0 3 3 3 0 AAA domain GTP_EFTU PF00009.27 ETO25302.1 - 0.42 10.1 0.0 0.42 10.1 0.0 3.6 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ETO25302.1 - 0.51 10.6 3.1 0.8 10.0 0.0 2.9 3 0 0 3 3 3 0 AAA domain 60KD_IMP PF02096.20 ETO25302.1 - 1.8 8.4 16.3 2 8.3 0.0 3.3 3 0 0 3 3 3 0 60Kd inner membrane protein DUF4199 PF13858.6 ETO25302.1 - 6.2 7.2 4.7 4.5 7.6 0.1 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) Prefoldin PF02996.17 ETO25303.1 - 7.5e-17 61.4 1.1 7.1e-16 58.2 0.2 2.2 2 0 0 2 2 2 1 Prefoldin subunit ETRAMP PF09716.10 ETO25303.1 - 0.18 11.9 1.5 11 6.2 0.1 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DOG1 PF14144.6 ETO25304.1 - 0.32 11.3 1.6 10 6.4 0.3 2.4 2 0 0 2 2 2 0 Seed dormancy control Fes1 PF08609.10 ETO25304.1 - 0.7 10.8 7.1 0.27 12.1 2.5 2.4 1 1 1 2 2 2 0 Nucleotide exchange factor Fes1 Uso1_p115_C PF04871.13 ETO25304.1 - 9 6.7 12.9 2.1 8.7 6.2 2.4 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DHHC PF01529.20 ETO25305.1 - 8.1 6.6 8.8 17 5.5 8.8 1.6 1 1 0 1 1 1 0 DHHC palmitoyltransferase RGS PF00615.19 ETO25306.1 - 1.2e-06 28.7 0.5 2.4e-06 27.8 0.5 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain PAH PF02671.21 ETO25307.1 - 0.14 12.4 2.6 0.15 12.3 0.7 2.0 2 0 0 2 2 2 0 Paired amphipathic helix repeat ALMT PF11744.8 ETO25307.1 - 0.48 9.2 14.6 0.7 8.7 14.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Macoilin PF09726.9 ETO25307.1 - 2.3 6.7 26.5 2.6 6.5 26.5 1.1 1 0 0 1 1 1 0 Macoilin family Utp14 PF04615.13 ETO25307.1 - 5 5.6 14.6 5.4 5.5 14.6 1.1 1 0 0 1 1 1 0 Utp14 protein CAP PF00188.26 ETO25309.1 - 0.0024 18.7 0.2 0.0083 17.0 0.0 1.9 2 0 0 2 2 2 1 Cysteine-rich secretory protein family Phage_X PF05155.15 ETO25309.1 - 0.061 13.7 1.4 0.13 12.7 0.1 2.2 2 0 0 2 2 2 0 Phage X family Sec3_C PF09763.9 ETO25310.1 - 5.7e-05 21.7 2.4 0.00015 20.4 0.8 1.9 2 0 0 2 2 2 1 Exocyst complex component Sec3 2-Hacid_dh_C PF02826.19 ETO25310.1 - 0.013 14.9 0.1 0.022 14.1 0.1 1.5 1 1 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain V-ATPase_H_C PF11698.8 ETO25313.1 - 5.5e-37 126.5 0.8 1.4e-36 125.1 0.2 2.0 2 0 0 2 2 2 1 V-ATPase subunit H V-ATPase_H_N PF03224.14 ETO25313.1 - 5.9e-08 32.4 2.6 7.4e-08 32.0 0.4 2.3 3 0 0 3 3 3 1 V-ATPase subunit H Arm PF00514.23 ETO25313.1 - 0.0006 19.8 0.0 1.7 8.8 0.0 2.8 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETO25313.1 - 0.005 17.2 0.0 0.012 16.0 0.0 1.6 1 0 0 1 1 1 1 HEAT repeats PhyH PF05721.13 ETO25314.1 - 1.3e-33 117.0 0.0 5.2e-33 115.1 0.0 2.0 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ETO25314.1 - 0.066 12.0 0.0 1.7 7.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1479) Abhydrolase_4 PF08386.10 ETO25315.1 - 0.03 14.4 0.0 0.066 13.3 0.0 1.6 1 0 0 1 1 1 0 TAP-like protein EMP70 PF02990.16 ETO25316.1 - 4.8e-29 101.4 0.2 6.3e-29 101.0 0.2 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 ISK_Channel PF02060.15 ETO25316.1 - 0.16 11.7 1.2 0.4 10.4 0.2 1.9 2 0 0 2 2 2 0 Slow voltage-gated potassium channel FLYWCH PF04500.16 ETO25317.1 - 0.072 13.2 6.2 0.39 10.9 4.4 2.7 1 1 1 2 2 2 0 FLYWCH zinc finger domain WRKY PF03106.15 ETO25317.1 - 0.63 10.3 9.4 0.86 9.9 3.6 2.6 2 1 0 2 2 2 0 WRKY DNA -binding domain DUF2142 PF09913.9 ETO25318.1 - 0.35 9.7 1.3 1.7 7.4 0.0 2.3 2 0 0 2 2 2 0 Predicted membrane protein (DUF2142) HCO3_cotransp PF00955.21 ETO25318.1 - 7.5 5.2 18.2 1 8.1 5.8 2.7 2 0 0 2 2 2 0 HCO3- transporter family DUF4548 PF15081.6 ETO25319.1 - 0.0062 16.4 0.3 0.038 13.8 0.0 2.2 2 0 0 2 2 2 1 Domain of unknown function (DUF4548) Presenilin PF01080.17 ETO25319.1 - 0.68 8.6 2.1 0.88 8.3 2.1 1.3 1 0 0 1 1 1 0 Presenilin Pex26 PF07163.12 ETO25319.1 - 1.7 7.9 7.1 2.9 7.1 7.1 1.3 1 0 0 1 1 1 0 Pex26 protein ORC_WH_C PF18137.1 ETO25319.1 - 4.8 7.3 8.3 5 7.2 6.8 1.7 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Adaptin_N PF01602.20 ETO25320.1 - 8.7e-79 265.5 16.8 1.1e-78 265.2 16.8 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT_2 PF13646.6 ETO25320.1 - 7.6e-11 42.3 4.5 1.4e-06 28.6 0.0 4.9 3 2 2 5 5 5 1 HEAT repeats Cnd1 PF12717.7 ETO25320.1 - 8.5e-08 32.4 11.8 1.3e-07 31.8 0.6 3.6 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO25320.1 - 4.8e-07 29.5 1.0 0.0055 16.9 0.0 4.6 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ETO25320.1 - 3.2e-05 24.3 1.8 0.24 12.0 0.0 4.7 4 1 1 5 5 5 2 HEAT-like repeat DUF4456 PF14644.6 ETO25320.1 - 0.0027 17.4 0.2 0.15 11.7 0.0 2.7 2 1 0 2 2 2 1 Domain of unknown function (DUF4456) GUN4_N PF16416.5 ETO25320.1 - 0.0054 16.7 0.0 5.4 7.1 0.0 2.9 2 0 0 2 2 2 2 ARM-like repeat domain, GUN4-N terminal ApoLp-III PF07464.11 ETO25320.1 - 0.019 15.1 0.2 0.11 12.6 0.1 2.2 2 0 0 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Vitellogenin_N PF01347.22 ETO25320.1 - 0.12 10.8 0.6 7.6 4.8 0.1 2.2 2 0 0 2 2 2 0 Lipoprotein amino terminal region RTP1_C1 PF10363.9 ETO25320.1 - 0.21 11.8 3.9 1 9.6 0.1 3.6 3 1 1 4 4 4 0 Required for nuclear transport of RNA pol II C-terminus 1 Arm PF00514.23 ETO25320.1 - 1 9.5 4.3 62 3.8 0.1 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat HSBP1 PF06825.12 ETO25320.1 - 6.9 6.6 7.2 4.4 7.3 0.1 3.9 4 1 0 4 4 4 0 Heat shock factor binding protein 1 Serum_albumin PF00273.20 ETO25321.1 - 0.022 14.5 2.1 0.022 14.5 1.0 1.5 1 1 0 1 1 1 0 Serum albumin family Pre-PUA PF17832.1 ETO25321.1 - 0.031 14.9 0.6 0.071 13.8 0.1 1.9 2 0 0 2 2 2 0 Pre-PUA-like domain Med8 PF10232.9 ETO25321.1 - 0.072 12.7 0.1 0.096 12.3 0.1 1.3 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription complex subunit 8 UCH_N PF16674.5 ETO25321.1 - 0.44 10.5 5.9 0.14 12.1 1.3 2.3 3 0 0 3 3 3 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 WD40 PF00400.32 ETO25322.1 - 1e-47 159.1 12.2 9.2e-09 35.8 0.0 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25322.1 - 1.6e-19 69.9 3.5 0.0076 16.5 0.0 7.1 2 1 5 7 7 6 6 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO25322.1 - 1.1e-08 35.0 2.8 0.0056 16.9 0.0 5.3 7 0 0 7 7 6 2 Kelch motif Ge1_WD40 PF16529.5 ETO25322.1 - 4.4e-08 32.5 1.2 4.9 6.0 0.0 6.1 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_1 PF01344.25 ETO25322.1 - 7.7e-08 31.8 1.9 0.00092 18.7 0.1 4.5 4 0 0 4 4 4 2 Kelch motif WD40_like PF17005.5 ETO25322.1 - 8.2e-07 28.6 6.0 0.0017 17.7 0.0 4.9 3 2 2 6 6 6 3 WD40-like domain Kelch_5 PF13854.6 ETO25322.1 - 0.001 19.0 1.3 4.5 7.4 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO25322.1 - 0.0013 18.9 0.0 0.0075 16.5 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain PALB2_WD40 PF16756.5 ETO25322.1 - 0.0035 16.3 3.5 0.097 11.6 0.2 3.0 1 1 2 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO25322.1 - 0.0056 15.3 1.0 0.77 8.2 0.1 3.1 1 1 2 3 3 3 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO25322.1 - 0.0087 15.4 0.2 17 4.7 0.0 3.5 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO25322.1 - 0.016 13.9 9.8 2.8 6.5 0.0 4.6 2 1 2 5 5 5 0 Nucleoporin Nup120/160 Coat_X PF07552.11 ETO25322.1 - 0.076 12.9 0.5 3.2 7.6 0.0 3.2 3 0 0 3 3 3 0 Spore Coat Protein X and V domain DUF4763 PF15960.5 ETO25322.1 - 0.085 12.1 3.7 0.15 11.4 3.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Nbs1_C PF08599.10 ETO25322.1 - 0.099 12.8 0.3 0.23 11.6 0.3 1.6 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 CSTF_C PF14304.6 ETO25322.1 - 0.1 12.2 0.1 0.19 11.3 0.1 1.4 1 0 0 1 1 1 0 Transcription termination and cleavage factor C-terminal DUF4085 PF13315.6 ETO25322.1 - 0.63 9.6 7.4 0.53 9.9 2.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF4085) Aldo_ket_red PF00248.21 ETO25323.1 - 2.1e-20 73.1 0.1 1.3e-14 54.1 0.0 2.2 1 1 1 2 2 2 2 Aldo/keto reductase family DSPc PF00782.20 ETO25324.1 - 8e-28 96.9 0.6 1.3e-16 60.7 0.0 2.6 1 1 1 2 2 2 2 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ETO25324.1 - 0.0002 21.5 0.0 0.00038 20.6 0.0 1.5 1 0 0 1 1 1 1 Inositol hexakisphosphate Rhodanese PF00581.20 ETO25324.1 - 0.00067 20.2 0.3 0.34 11.5 0.0 2.4 2 0 0 2 2 2 2 Rhodanese-like domain Y_phosphatase PF00102.27 ETO25324.1 - 0.0034 17.0 0.2 0.0067 16.0 0.2 1.5 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DUF5092 PF17010.5 ETO25324.1 - 0.0086 16.0 0.5 0.016 15.2 0.5 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5092) Phenyl_P_gamma PF09662.10 ETO25325.1 - 0.13 12.4 1.4 1.7 8.9 0.1 2.5 1 1 1 2 2 2 0 Phenylphosphate carboxylase gamma subunit (Phenyl_P_gamma) Acyl_transf_1 PF00698.21 ETO25326.1 - 0.0057 16.2 0.2 0.0067 16.0 0.2 1.0 1 0 0 1 1 1 1 Acyl transferase domain DASH_Spc34 PF08657.10 ETO25326.1 - 0.081 12.7 0.3 0.095 12.5 0.3 1.3 1 0 0 1 1 1 0 DASH complex subunit Spc34 ETC_C1_NDUFA5 PF04716.14 ETO25328.1 - 2e-19 69.1 0.1 3.4e-19 68.4 0.1 1.4 1 0 0 1 1 1 1 ETC complex I subunit conserved region RIBIOP_C PF04950.12 ETO25329.1 - 3.2e-74 250.0 0.0 3.2e-74 250.0 0.0 3.3 3 1 1 4 4 4 1 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal AARP2CN PF08142.12 ETO25330.1 - 8.3e-31 105.9 0.1 4e-30 103.7 0.0 2.3 2 0 0 2 2 2 1 AARP2CN (NUC121) domain GTP_EFTU PF00009.27 ETO25330.1 - 4.5e-05 23.1 0.0 0.00036 20.1 0.0 2.1 1 1 0 2 2 2 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO25330.1 - 0.00066 19.7 0.0 0.0067 16.5 0.0 2.7 1 1 0 1 1 1 1 50S ribosome-binding GTPase RNA_helicase PF00910.22 ETO25330.1 - 0.0043 17.4 3.4 2.7 8.4 0.0 3.7 3 0 0 3 3 3 1 RNA helicase AAA_22 PF13401.6 ETO25330.1 - 0.029 14.6 0.1 0.11 12.8 0.0 2.1 2 1 0 2 2 2 0 AAA domain AAA PF00004.29 ETO25330.1 - 0.1 13.0 0.0 0.24 11.8 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO25330.1 - 0.12 12.7 0.0 0.32 11.4 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain KH_1 PF00013.29 ETO25331.1 - 2.4e-10 40.1 0.0 0.0012 18.6 0.0 4.3 4 0 0 4 4 4 3 KH domain Collagen PF01391.18 ETO25331.1 - 0.012 15.4 17.4 0.021 14.6 17.4 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) IF-2 PF11987.8 ETO25332.1 - 2.7e-16 59.6 0.0 5.5e-16 58.6 0.0 1.5 1 0 0 1 1 1 1 Translation-initiation factor 2 GTP_EFTU PF00009.27 ETO25333.1 - 5.9e-24 84.7 7.5 2.8e-18 66.2 0.5 4.0 3 1 0 3 3 3 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO25333.1 - 6.8e-06 26.1 0.0 1.7e-05 24.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ETO25333.1 - 0.0035 16.8 0.0 0.88 9.0 0.0 2.5 2 0 0 2 2 2 2 Signal recognition particle receptor beta subunit Roc PF08477.13 ETO25333.1 - 0.05 13.8 0.2 0.14 12.4 0.0 2.0 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DUF4057 PF13266.6 ETO25333.1 - 0.12 12.0 1.4 0.27 10.9 0.9 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4057) ATP_bind_1 PF03029.17 ETO25333.1 - 0.12 12.1 0.0 4.7 6.9 0.0 2.7 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein HAUS6_N PF14661.6 ETO25333.1 - 0.15 11.6 2.1 0.33 10.5 2.1 1.5 1 0 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus DEAD PF00270.29 ETO25334.1 - 4.9e-42 143.7 0.1 9.1e-42 142.8 0.1 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO25334.1 - 1.8e-29 102.3 2.9 2.1e-28 98.9 0.1 3.4 3 0 0 3 3 3 1 Helicase conserved C-terminal domain Zip PF02535.22 ETO25334.1 - 0.0076 15.5 5.0 0.031 13.5 0.8 2.5 2 0 0 2 2 2 1 ZIP Zinc transporter OTT_1508_deam PF14441.6 ETO25334.1 - 0.097 12.7 0.1 0.54 10.3 0.0 2.2 2 0 0 2 2 2 0 OTT_1508-like deaminase DDHD PF02862.17 ETO25334.1 - 0.13 12.4 3.3 10 6.2 1.2 2.4 2 0 0 2 2 2 0 DDHD domain MAGE PF01454.19 ETO25334.1 - 3.3 7.4 8.8 0.058 13.1 1.2 1.9 2 0 0 2 2 2 0 MAGE family WD40 PF00400.32 ETO25336.1 - 0.00076 20.2 0.2 0.0025 18.6 0.2 1.9 1 1 0 1 1 1 1 WD domain, G-beta repeat PB1 PF00564.24 ETO25337.1 - 1.2e-13 50.7 0.6 1.6e-13 50.4 0.6 1.1 1 0 0 1 1 1 1 PB1 domain RNA_pol_Rpb1_7 PF04990.12 ETO25337.1 - 0.034 14.2 1.9 0.034 14.2 1.9 1.5 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 7 DUF3791 PF12668.7 ETO25340.1 - 0.1 12.7 0.3 19 5.4 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) DEAD PF00270.29 ETO25341.1 - 2.2e-48 164.4 0.0 1.4e-47 161.7 0.0 2.0 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO25341.1 - 4.8e-32 110.6 0.0 2e-31 108.6 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO25341.1 - 7.8e-05 22.7 0.2 0.00052 20.1 0.0 2.3 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit UTP25 PF06862.12 ETO25341.1 - 0.00063 18.6 0.0 0.14 10.9 0.0 2.3 1 1 0 1 1 1 1 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 COesterase PF00135.28 ETO25342.1 - 0.27 10.0 1.9 0.38 9.6 1.9 1.1 1 0 0 1 1 1 0 Carboxylesterase family Scs3p PF10261.9 ETO25342.1 - 0.43 10.1 14.4 0.096 12.2 8.4 2.5 2 1 0 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM Phage_holin_3_6 PF07332.11 ETO25342.1 - 2.2 8.3 12.3 1.4 9.0 0.8 2.7 2 1 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III fn3 PF00041.21 ETO25343.1 - 0.00017 21.9 0.0 0.00062 20.1 0.0 2.0 1 0 0 1 1 1 1 Fibronectin type III domain FAM176 PF14851.6 ETO25344.1 - 0.82 9.3 5.0 40 3.8 0.0 2.6 2 0 0 2 2 2 0 FAM176 family Apis_Csd PF11671.8 ETO25344.1 - 2.5 8.1 8.3 0.2 11.7 3.2 1.8 2 0 0 2 2 2 0 Complementary sex determiner protein zf-NOSIP PF15906.5 ETO25345.1 - 0.029 14.5 0.0 0.075 13.2 0.0 1.7 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein DUF2207 PF09972.9 ETO25345.1 - 0.18 10.5 5.7 0.49 9.1 0.0 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) DcuC PF03606.15 ETO25345.1 - 2.2 6.7 11.2 0.019 13.5 1.5 2.1 2 1 0 2 2 2 0 C4-dicarboxylate anaerobic carrier Vma12 PF11712.8 ETO25345.1 - 2.4 8.2 6.0 0.88 9.6 0.2 2.3 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Alg6_Alg8 PF03155.15 ETO25346.1 - 1.3e-61 209.0 2.7 1.6e-61 208.7 2.7 1.0 1 0 0 1 1 1 1 ALG6, ALG8 glycosyltransferase family Ribonuclease_T2 PF00445.18 ETO25347.1 - 5.8e-14 52.7 1.2 7e-14 52.5 1.2 1.0 1 0 0 1 1 1 1 Ribonuclease T2 family Glyco_hydro_63 PF03200.16 ETO25348.1 - 8.5e-39 133.6 0.1 9.4e-39 133.5 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain DUF3606 PF12244.8 ETO25348.1 - 0.01 15.8 0.0 0.018 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF3606) P4Ha_N PF08336.11 ETO25348.1 - 0.13 12.3 0.0 0.15 12.0 0.0 1.2 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region Glyco_hydro_63 PF03200.16 ETO25349.1 - 7.8e-15 54.6 0.0 1.1e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Glyco_hydro_63N PF16923.5 ETO25350.1 - 2e-19 70.6 1.4 4.3e-19 69.5 1.4 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 N-terminal domain OPA3 PF07047.12 ETO25351.1 - 2.6e-07 30.5 0.1 2.2e-06 27.5 0.0 2.1 2 0 0 2 2 2 1 Optic atrophy 3 protein (OPA3) DUF3439 PF11921.8 ETO25352.1 - 0.3 11.0 6.9 1.6 8.8 6.9 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Hyccin PF09790.9 ETO25353.1 - 8.8e-11 41.5 0.6 1.1e-05 24.7 0.0 3.3 4 0 0 4 4 4 2 Hyccin Shisa PF13908.6 ETO25353.1 - 0.032 14.5 0.6 0.032 14.5 0.6 3.0 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator NPP1 PF05630.11 ETO25353.1 - 0.84 9.7 3.6 4.1 7.5 0.2 2.8 3 0 0 3 3 3 0 Necrosis inducing protein (NPP1) Myb_DNA-binding PF00249.31 ETO25354.1 - 0.0044 17.2 0.0 0.0082 16.3 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain zf-RING_2 PF13639.6 ETO25356.1 - 2.8e-08 33.9 9.6 2.8e-08 33.9 9.6 2.8 2 0 0 2 2 2 1 Ring finger domain FANCL_C PF11793.8 ETO25356.1 - 1.5e-05 25.1 4.8 4.9e-05 23.4 4.8 1.9 1 0 0 1 1 1 1 FANCL C-terminal domain zf-rbx1 PF12678.7 ETO25356.1 - 0.00014 22.0 8.5 0.00073 19.8 8.7 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO25356.1 - 0.00036 20.5 3.1 0.0012 18.9 3.1 1.9 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ETO25356.1 - 0.00048 20.2 6.8 0.0017 18.5 6.8 2.1 1 0 0 1 1 1 1 RING-variant domain RWD PF05773.22 ETO25356.1 - 0.0013 19.0 0.5 0.0055 17.0 0.5 2.1 1 0 0 1 1 1 1 RWD domain Zn_ribbon_17 PF17120.5 ETO25356.1 - 0.0022 17.6 4.3 0.0022 17.6 4.3 3.1 3 0 0 3 3 3 1 Zinc-ribbon, C4HC2 type GAGA PF09237.11 ETO25356.1 - 0.12 12.2 4.0 0.55 10.1 0.1 2.9 3 0 0 3 3 3 0 GAGA factor DUF4407 PF14362.6 ETO25356.1 - 0.22 10.8 1.3 0.45 9.8 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mannosyl_trans3 PF11051.8 ETO25357.1 - 0.00035 20.0 0.0 0.00047 19.6 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Cons_hypoth95 PF03602.15 ETO25357.1 - 0.059 13.0 0.2 0.19 11.3 0.1 1.8 2 0 0 2 2 2 0 Conserved hypothetical protein 95 Spc7 PF08317.11 ETO25358.1 - 0.64 8.8 29.0 1.3 7.9 28.3 1.9 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF740 PF05340.12 ETO25358.1 - 1.2 7.9 9.9 1.5 7.5 9.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Fzo_mitofusin PF04799.13 ETO25358.1 - 1.5 8.4 12.8 4.9 6.7 12.8 2.0 1 1 0 1 1 1 0 fzo-like conserved region DUF3552 PF12072.8 ETO25358.1 - 1.6 8.1 23.1 2.6 7.4 23.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) Histidinol_dh PF00815.20 ETO25358.1 - 2.4 7.1 5.7 3.4 6.6 5.7 1.2 1 0 0 1 1 1 0 Histidinol dehydrogenase DUF948 PF06103.11 ETO25358.1 - 5.6 7.3 6.3 6 7.2 2.9 2.6 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) LMBR1 PF04791.16 ETO25358.1 - 6.5 5.5 11.1 6.8 5.5 11.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Mo25 PF08569.11 ETO25359.1 - 3.7e-14 52.9 6.5 3.7e-14 52.9 6.5 1.8 1 1 1 2 2 2 1 Mo25-like SMYLE_N PF18615.1 ETO25359.1 - 0.014 15.0 3.5 0.015 14.9 3.5 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain PC-Esterase PF13839.6 ETO25359.1 - 0.059 13.1 4.3 0.093 12.5 4.3 1.2 1 0 0 1 1 1 0 GDSL/SGNH-like Acyl-Esterase family found in Pmr5 and Cas1p O-antigen_lig PF13425.6 ETO25359.1 - 0.15 10.8 13.9 0.2 10.4 13.9 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Presenilin PF01080.17 ETO25359.1 - 0.82 8.4 6.2 1.1 8.0 6.2 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ETO25359.1 - 7.2 6.3 7.6 21 4.8 7.6 1.7 1 1 0 1 1 1 0 FAM176 family CLN3 PF02487.17 ETO25359.1 - 8.4 5.3 7.2 11 4.9 7.2 1.2 1 0 0 1 1 1 0 CLN3 protein TMEM208_SND2 PF05620.11 ETO25362.1 - 0.013 15.3 4.4 1.8 8.3 0.3 2.8 2 0 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 ETRAMP PF09716.10 ETO25362.1 - 0.1 12.6 0.1 0.1 12.6 0.1 3.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) ABC_export PF16962.5 ETO25362.1 - 0.11 10.9 6.5 0.025 13.0 0.5 2.2 2 0 0 2 2 2 0 Putative ABC exporter EOS1 PF12326.8 ETO25362.1 - 0.47 10.4 0.1 0.47 10.4 0.1 3.9 2 1 0 3 3 3 0 N-glycosylation protein BUD22 PF09073.10 ETO25362.1 - 0.56 9.5 47.4 0.14 11.4 24.3 2.8 3 0 0 3 3 3 0 BUD22 RGS PF00615.19 ETO25363.1 - 4.2e-06 27.0 1.6 5.9e-06 26.5 0.1 2.1 2 1 0 2 2 2 1 Regulator of G protein signaling domain SelP_N PF04592.14 ETO25363.1 - 1.1 8.6 10.6 2.2 7.7 10.6 1.3 1 0 0 1 1 1 0 Selenoprotein P, N terminal region E1-E2_ATPase PF00122.20 ETO25363.1 - 3 7.3 9.6 3 7.3 2.8 2.4 2 0 0 2 2 2 0 E1-E2 ATPase YukD PF08817.10 ETO25364.1 - 0.11 13.3 0.1 0.16 12.6 0.1 1.2 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein YukD PB1 PF00564.24 ETO25365.1 - 7.3e-14 51.5 0.1 9.3e-14 51.1 0.1 1.1 1 0 0 1 1 1 1 PB1 domain REJ PF02010.15 ETO25366.1 - 1e-10 41.0 8.1 1e-10 41.0 8.1 2.1 3 1 0 3 3 3 1 REJ domain GPS PF01825.21 ETO25366.1 - 3.9e-09 36.9 4.0 1.1e-08 35.5 4.0 1.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif PLDc_N PF13396.6 ETO25366.1 - 0.96 9.4 6.8 0.13 12.3 1.3 2.3 2 0 0 2 2 2 0 Phospholipase_D-nuclease N-terminal PT PF04886.12 ETO25368.1 - 0.0019 17.7 32.2 23 4.6 32.2 2.6 1 1 0 1 1 1 1 PT repeat RRM_1 PF00076.22 ETO25370.1 - 2e-08 33.9 0.0 8.2e-06 25.6 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PRP38_assoc PF12871.7 ETO25370.1 - 0.6 10.7 20.1 1.2 9.8 20.1 1.5 1 0 0 1 1 1 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term FtsH_ext PF06480.15 ETO25371.1 - 0.071 13.5 1.1 0.17 12.3 1.1 1.7 1 0 0 1 1 1 0 FtsH Extracellular ODV-E18 PF10717.9 ETO25371.1 - 0.72 9.8 2.8 7.9 6.4 0.1 2.3 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 Metallophos PF00149.28 ETO25374.1 - 5.3e-07 30.3 0.0 1.3e-06 29.1 0.0 1.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase EF-hand_6 PF13405.6 ETO25376.1 - 0.00011 21.9 1.1 0.0027 17.5 0.0 3.3 4 0 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 ETO25376.1 - 0.00036 20.9 3.8 0.065 13.7 0.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair RRM_1 PF00076.22 ETO25378.1 - 6.9e-10 38.6 0.0 1.6e-06 27.8 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) ALMT PF11744.8 ETO25378.1 - 0.0035 16.2 7.0 0.0045 15.9 7.0 1.1 1 0 0 1 1 1 1 Aluminium activated malate transporter RRM_3 PF08777.11 ETO25378.1 - 0.01 15.9 0.1 0.71 9.9 0.0 2.5 2 1 0 2 2 2 0 RNA binding motif Endostatin PF06482.11 ETO25378.1 - 0.081 12.4 6.1 12 5.2 6.2 2.1 2 0 0 2 2 2 0 Collagenase NC10 and Endostatin SelP_N PF04592.14 ETO25378.1 - 0.097 12.1 22.7 0.057 12.8 20.6 1.6 2 0 0 2 2 2 0 Selenoprotein P, N terminal region RP-C_C PF11800.8 ETO25378.1 - 0.37 10.9 6.2 0.54 10.3 6.2 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Macoilin PF09726.9 ETO25378.1 - 0.39 9.2 14.7 0.5 8.9 14.7 1.1 1 0 0 1 1 1 0 Macoilin family NicO PF03824.16 ETO25378.1 - 1.2 8.4 5.3 1.8 7.8 5.3 1.3 1 0 0 1 1 1 0 High-affinity nickel-transport protein Menin PF05053.13 ETO25378.1 - 1.4 7.2 7.7 1.6 7.0 7.7 1.1 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO25378.1 - 2.1 7.5 13.6 3 7.0 13.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Tim54 PF11711.8 ETO25378.1 - 2.3 6.9 5.9 2 7.1 3.3 1.9 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 NST1 PF13945.6 ETO25378.1 - 2.8 8.0 17.0 4.5 7.3 17.0 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator SR-25 PF10500.9 ETO25378.1 - 5 6.7 10.6 7.7 6.1 10.6 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 ETO25378.1 - 6.2 5.5 9.5 8 5.1 9.5 1.1 1 0 0 1 1 1 0 Presenilin EVI2A PF05399.11 ETO25378.1 - 9.8 5.7 12.5 16 5.0 12.5 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) RRM_1 PF00076.22 ETO25379.1 - 1.9e-31 107.7 0.0 5.2e-18 64.6 0.0 2.3 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO25379.1 - 1.2e-05 25.3 0.0 9e-05 22.4 0.0 2.2 2 0 0 2 2 2 1 RNA binding domain RRM_3 PF08777.11 ETO25379.1 - 6.8e-05 22.9 0.0 0.0027 17.7 0.0 2.2 1 1 1 2 2 2 1 RNA binding motif RRM_5 PF13893.6 ETO25379.1 - 0.00058 19.4 0.0 0.051 13.2 0.0 2.4 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Limkain-b1 PF11608.8 ETO25379.1 - 0.06 13.4 0.0 0.23 11.6 0.0 1.9 2 0 0 2 2 2 0 Limkain b1 DUF4283 PF14111.6 ETO25379.1 - 0.069 12.7 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) RRM_occluded PF16842.5 ETO25379.1 - 0.11 12.4 0.0 0.3 11.0 0.0 1.7 2 0 0 2 2 2 0 Occluded RNA-recognition motif Nup35_RRM_2 PF14605.6 ETO25379.1 - 0.18 11.8 0.0 12 6.0 0.0 2.3 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif TPR_17 PF13431.6 ETO25380.1 - 0.0023 18.2 0.3 3.3 8.3 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat Ribosomal_L16 PF00252.18 ETO25380.1 - 0.0059 16.6 0.2 0.01 15.8 0.2 1.4 1 0 0 1 1 1 1 Ribosomal protein L16p/L10e DUF547 PF04784.14 ETO25380.1 - 0.053 13.5 0.0 0.13 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF547 TPR_11 PF13414.6 ETO25380.1 - 0.073 12.8 1.4 0.25 11.0 0.0 2.2 2 0 0 2 2 2 0 TPR repeat DUF5374 PF17344.2 ETO25380.1 - 3 7.8 4.9 1.4 8.9 0.7 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5374) KLRAQ PF10205.9 ETO25381.1 - 1.9 8.7 10.8 0.095 12.9 3.4 2.6 2 0 0 2 2 2 0 Predicted coiled-coil domain-containing protein PLDc PF00614.22 ETO25382.1 - 0.0074 16.4 0.1 0.091 13.0 0.0 2.7 3 0 0 3 3 3 1 Phospholipase D Active site motif Acetyltransf_10 PF13673.7 ETO25383.1 - 3.4e-10 39.9 0.0 5.2e-10 39.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO25383.1 - 4.3e-10 39.9 0.0 5.8e-10 39.4 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO25383.1 - 2.4e-08 34.3 0.0 3.8e-08 33.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ETO25383.1 - 0.12 12.5 0.1 0.39 10.8 0.1 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain SSP160 PF06933.11 ETO25384.1 - 0.04 12.1 18.6 0.042 12.1 9.2 2.2 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 FAD_binding_2 PF00890.24 ETO25385.1 - 1e-41 143.4 0.0 1.7e-41 142.7 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETO25385.1 - 1.9e-08 34.3 0.0 9.1e-08 32.1 0.1 1.9 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETO25385.1 - 0.00018 21.7 0.3 0.00054 20.1 0.1 1.9 2 0 0 2 2 2 1 NAD(P)-binding Rossmann-like domain Pyr_redox_2 PF07992.14 ETO25385.1 - 0.0029 16.9 0.3 0.014 14.7 0.3 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase MCRA PF06100.11 ETO25385.1 - 0.13 11.1 0.0 2.1 7.1 0.0 2.0 2 0 0 2 2 2 0 MCRA family FAD_binding_2 PF00890.24 ETO25386.1 - 7.2e-24 84.6 0.0 8.2e-24 84.4 0.0 1.0 1 0 0 1 1 1 1 FAD binding domain SAPS PF04499.15 ETO25387.1 - 3e-41 141.8 23.2 1.8e-24 86.4 3.1 4.1 4 0 0 4 4 4 4 SIT4 phosphatase-associated protein Na_trans_assoc PF06512.13 ETO25387.1 - 1.2 9.4 7.8 2.7 8.2 7.8 1.5 1 0 0 1 1 1 0 Sodium ion transport-associated SMN PF06003.12 ETO25387.1 - 3.3 6.9 5.5 5.4 6.2 5.5 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) AKAP2_C PF15304.6 ETO25388.1 - 3.7e-05 23.2 6.0 5.1e-05 22.7 6.0 1.2 1 0 0 1 1 1 1 A-kinase anchor protein 2 C-terminus Kri1_C PF12936.7 ETO25388.1 - 0.035 14.3 2.0 0.035 14.3 2.0 2.6 2 2 0 2 2 2 0 KRI1-like family C-terminal Mit_KHE1 PF10173.9 ETO25388.1 - 0.32 11.0 4.6 0.46 10.5 4.6 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related CDC45 PF02724.14 ETO25388.1 - 0.95 7.7 9.0 1 7.6 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein XRN_M PF17846.1 ETO25388.1 - 2.5 7.0 8.8 3 6.7 8.8 1.1 1 0 0 1 1 1 0 Xrn1 helical domain AIF_C PF14721.6 ETO25388.1 - 3.4 8.0 10.0 0.21 11.9 1.5 2.2 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Neur_chan_memb PF02932.16 ETO25388.1 - 8 6.4 7.1 13 5.8 7.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO25388.1 - 8.2 5.1 10.8 10 4.8 10.8 1.2 1 0 0 1 1 1 0 Presenilin Drf_GBD PF06371.13 ETO25388.1 - 8.9 5.8 11.3 20 4.7 11.0 1.9 1 1 1 2 2 2 0 Diaphanous GTPase-binding Domain TPR_8 PF13181.6 ETO25389.1 - 1.2e-05 25.2 0.3 0.0068 16.5 0.1 3.2 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF2264 PF10022.9 ETO25389.1 - 0.00054 19.2 0.2 0.001 18.2 0.2 1.4 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2264) TPR_2 PF07719.17 ETO25389.1 - 0.0007 19.5 3.8 0.021 14.9 0.1 4.2 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO25389.1 - 0.00093 18.9 4.3 0.077 12.9 0.1 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO25389.1 - 0.0015 19.1 0.0 0.0035 17.9 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO25389.1 - 0.026 14.6 0.0 0.29 11.3 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat SR-25 PF10500.9 ETO25389.1 - 0.5 9.9 12.5 0.03 13.9 5.9 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein MFAP1 PF06991.11 ETO25389.1 - 3.8 7.3 16.3 0.14 11.9 0.5 2.4 2 0 0 2 2 2 0 Microfibril-associated/Pre-mRNA processing HemY_N PF07219.13 ETO25390.1 - 0.006 16.8 1.2 0.006 16.8 1.2 2.3 2 1 0 2 2 2 1 HemY protein N-terminus DUF3671 PF12420.8 ETO25390.1 - 0.016 15.3 3.7 0.016 15.3 3.7 2.5 2 1 1 3 3 3 0 Protein of unknown function DUF4520 PF15016.6 ETO25390.1 - 0.029 14.4 0.1 0.072 13.2 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4520) Ni_hydr_CYTB PF01292.20 ETO25390.1 - 0.034 13.7 0.3 3.1 7.3 0.1 2.2 2 0 0 2 2 2 0 Prokaryotic cytochrome b561 DUF3981 PF13139.6 ETO25390.1 - 0.044 14.2 0.3 0.094 13.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3981) Shisa PF13908.6 ETO25390.1 - 0.17 12.1 5.3 0.21 11.8 0.1 2.8 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator DUF4199 PF13858.6 ETO25390.1 - 0.26 11.7 9.9 0.04 14.3 1.7 2.5 2 2 0 2 2 2 0 Protein of unknown function (DUF4199) Wzy_C PF04932.15 ETO25390.1 - 8.5 6.0 7.2 5.2 6.7 0.5 2.6 2 1 1 3 3 3 0 O-Antigen ligase DUF3228 PF11539.8 ETO25391.1 - 0.016 14.7 1.2 0.032 13.7 1.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3228) MHYT PF03707.16 ETO25392.1 - 0.029 14.5 0.5 0.057 13.6 0.5 1.4 1 0 0 1 1 1 0 Bacterial signalling protein N terminal repeat Cupin_8 PF13621.6 ETO25392.1 - 0.12 12.1 2.5 0.66 9.6 0.3 2.7 2 1 0 2 2 2 0 Cupin-like domain JmjC PF02373.22 ETO25392.1 - 4.2 7.8 8.2 1.3 9.5 0.9 3.9 4 1 0 4 4 4 0 JmjC domain, hydroxylase NAPRTase_N PF17767.1 ETO25393.1 - 0.041 14.3 1.3 0.45 10.9 0.0 2.8 2 1 1 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain RRM_1 PF00076.22 ETO25394.1 - 2e-06 27.5 0.0 0.0036 17.1 0.0 2.9 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) KCNQ2_u3 PF16642.5 ETO25394.1 - 0.17 12.9 0.2 0.17 12.9 0.2 4.4 4 1 0 4 4 4 0 Unstructured region on Potassium channel subunit alpha KvLQT2 CAF1C_H4-bd PF12265.8 ETO25395.1 - 1.3e-06 28.5 1.4 1.3e-06 28.5 1.4 2.3 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex Cyclin PF08613.11 ETO25395.1 - 5.5 7.3 9.1 1.6 9.1 1.3 2.2 2 0 0 2 2 2 0 Cyclin WD40 PF00400.32 ETO25396.1 - 3.7e-11 43.4 3.1 0.044 14.7 0.0 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25396.1 - 0.00031 21.0 0.3 0.49 10.7 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain FAA_hydrolase PF01557.18 ETO25397.1 - 3.6e-67 226.2 0.0 4e-67 226.1 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Peptidase_M23 PF01551.22 ETO25399.1 - 0.00028 21.0 0.0 0.00062 19.9 0.0 1.6 1 0 0 1 1 1 1 Peptidase family M23 AAR2 PF05282.11 ETO25399.1 - 0.032 13.6 0.3 0.037 13.4 0.3 1.1 1 0 0 1 1 1 0 AAR2 protein Presenilin PF01080.17 ETO25399.1 - 0.048 12.4 1.1 0.056 12.2 1.1 1.1 1 0 0 1 1 1 0 Presenilin Apis_Csd PF11671.8 ETO25399.1 - 0.051 13.6 8.5 0.072 13.1 8.5 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein RnfC_N PF13375.6 ETO25399.1 - 0.11 12.4 0.0 0.2 11.6 0.0 1.4 1 0 0 1 1 1 0 RnfC Barrel sandwich hybrid domain Menin PF05053.13 ETO25399.1 - 0.89 7.8 9.5 1.1 7.5 9.5 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO25399.1 - 1 10.0 15.1 1.6 9.3 15.1 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain Folliculin PF11704.8 ETO25399.1 - 2.6 7.9 5.3 3.7 7.4 5.3 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport RRM_1 PF00076.22 ETO25400.1 - 0.0094 15.8 0.0 0.034 14.0 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHASE8 PF17152.4 ETO25400.1 - 0.054 13.7 0.0 0.08 13.2 0.0 1.3 1 0 0 1 1 1 0 Periplasmic sensor domain MMTV_SAg PF01054.17 ETO25400.1 - 0.059 12.9 1.5 0.091 12.3 1.5 1.3 1 0 0 1 1 1 0 Mouse mammary tumour virus superantigen DUF5358 PF17311.2 ETO25400.1 - 0.092 12.8 3.2 0.16 12.0 3.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5358) Gaa1 PF04114.14 ETO25400.1 - 0.11 11.5 0.7 0.14 11.1 0.7 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component DUF572 PF04502.13 ETO25400.1 - 0.6 9.7 13.3 0.71 9.4 13.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Peptidase_S49_N PF08496.10 ETO25400.1 - 1.5 8.9 12.2 2.9 7.9 0.6 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SURF6 PF04935.12 ETO25400.1 - 5.9 6.6 27.4 0.77 9.5 13.1 2.3 1 1 1 2 2 2 0 Surfeit locus protein 6 bZIP_1 PF00170.21 ETO25401.1 - 0.25 11.5 10.6 0.15 12.2 1.0 3.6 3 1 0 3 3 3 0 bZIP transcription factor FAM76 PF16046.5 ETO25401.1 - 1 8.6 17.3 1.3 8.3 17.3 1.2 1 0 0 1 1 1 0 FAM76 protein GrpE PF01025.19 ETO25401.1 - 1.3 8.7 10.0 1.4 8.6 0.8 2.3 2 0 0 2 2 2 0 GrpE DUF3987 PF13148.6 ETO25401.1 - 1.4 7.9 8.7 6.1 5.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) Swi5 PF07061.11 ETO25401.1 - 8.4 6.6 11.3 8.6 6.5 1.7 3.1 3 0 0 3 3 3 0 Swi5 APG6_N PF17675.1 ETO25401.1 - 9.5 6.8 21.3 5.9e+03 -2.3 21.3 2.3 1 1 0 1 1 1 0 Apg6 coiled-coil region APG6_N PF17675.1 ETO25402.1 - 0.00035 21.1 23.6 0.002 18.6 5.5 2.7 3 0 0 3 3 3 2 Apg6 coiled-coil region CALCOCO1 PF07888.11 ETO25402.1 - 0.00041 19.3 3.9 0.00041 19.3 3.9 2.3 2 0 0 2 2 2 1 Calcium binding and coiled-coil domain (CALCOCO1) like Laminin_I PF06008.14 ETO25402.1 - 0.0039 16.9 5.3 0.0039 16.9 5.3 2.3 2 0 0 2 2 2 1 Laminin Domain I AAA_13 PF13166.6 ETO25402.1 - 0.0053 15.5 2.1 0.0053 15.5 2.1 2.4 3 0 0 3 3 3 1 AAA domain ATG16 PF08614.11 ETO25402.1 - 0.0069 16.6 5.6 0.0069 16.6 5.6 2.4 2 0 0 2 2 2 1 Autophagy protein 16 (ATG16) Spc24 PF08286.11 ETO25402.1 - 0.0093 16.2 1.6 0.0093 16.2 1.6 3.2 3 1 0 3 3 2 1 Spc24 subunit of Ndc80 PI3K_P85_iSH2 PF16454.5 ETO25402.1 - 0.025 14.2 1.7 0.025 14.2 1.7 2.7 2 1 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Jnk-SapK_ap_N PF09744.9 ETO25402.1 - 0.029 14.6 7.2 0.029 14.6 7.2 3.1 3 1 0 3 3 3 0 JNK_SAPK-associated protein-1 Spc7 PF08317.11 ETO25402.1 - 0.036 13.0 16.1 0.41 9.5 5.2 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein TraF_2 PF13729.6 ETO25402.1 - 0.038 13.4 2.3 0.05 13.0 0.1 1.8 1 1 0 2 2 2 0 F plasmid transfer operon, TraF, protein DUF5082 PF16888.5 ETO25402.1 - 0.067 13.5 17.3 0.41 10.9 4.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) GAS PF13851.6 ETO25402.1 - 0.072 12.4 24.5 0.1 11.9 6.4 2.5 3 0 0 3 3 3 0 Growth-arrest specific micro-tubule binding Na_trans_assoc PF06512.13 ETO25402.1 - 0.26 11.5 6.2 0.56 10.5 6.2 1.6 1 0 0 1 1 1 0 Sodium ion transport-associated Laminin_II PF06009.12 ETO25402.1 - 0.3 11.1 14.6 0.41 10.7 4.0 2.3 2 0 0 2 2 2 0 Laminin Domain II BLOC1_2 PF10046.9 ETO25402.1 - 0.37 11.1 13.7 2.4 8.5 3.4 2.4 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4140 PF13600.6 ETO25402.1 - 0.4 11.1 15.8 3.1 8.3 0.6 3.3 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) SOGA PF11365.8 ETO25402.1 - 0.68 11.1 13.7 1.2 10.3 0.3 2.7 3 0 0 3 3 2 0 Protein SOGA CENP-F_leu_zip PF10473.9 ETO25402.1 - 0.71 9.9 25.4 0.26 11.3 5.2 3.4 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HemX PF04375.14 ETO25402.1 - 0.74 9.0 15.5 0.38 10.0 4.3 2.1 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase ADIP PF11559.8 ETO25402.1 - 0.89 9.6 24.0 0.55 10.3 8.8 2.5 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Syntaxin-6_N PF09177.11 ETO25402.1 - 0.9 10.1 10.3 1.8 9.1 1.8 2.4 2 0 0 2 2 2 0 Syntaxin 6, N-terminal DUF948 PF06103.11 ETO25402.1 - 1.4 9.3 8.2 2.7 8.3 1.3 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ETO25402.1 - 1.5 8.9 11.1 1.4 9.0 3.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DUF3450 PF11932.8 ETO25402.1 - 1.6 8.0 22.1 0.98 8.7 9.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Uds1 PF15456.6 ETO25402.1 - 1.8 8.7 19.6 3.3e+02 1.4 19.6 3.1 1 1 0 1 1 1 0 Up-regulated During Septation DUF4795 PF16043.5 ETO25402.1 - 2.2 7.8 22.5 0.31 10.6 5.2 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4795) MCU PF04678.13 ETO25402.1 - 2.3 8.3 8.3 1.2 9.2 0.7 2.4 2 0 0 2 2 2 0 Mitochondrial calcium uniporter DASH_Dad4 PF08650.10 ETO25402.1 - 2.8 8.0 8.3 0.29 11.1 2.4 2.4 2 2 1 3 3 3 0 DASH complex subunit Dad4 V_ATPase_I PF01496.19 ETO25402.1 - 3.1 5.6 15.0 3.8 5.3 12.8 1.9 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family TMF_TATA_bd PF12325.8 ETO25402.1 - 4.2 7.6 18.0 6.2 7.1 6.6 3.0 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding FapA PF03961.13 ETO25402.1 - 4.3 5.8 19.3 0.081 11.5 6.3 2.3 1 1 1 2 2 2 0 Flagellar Assembly Protein A SlyX PF04102.12 ETO25402.1 - 4.9 7.8 15.1 0.64 10.7 6.8 2.7 2 0 0 2 2 2 0 SlyX Noelin-1 PF12308.8 ETO25402.1 - 5.3 7.1 8.6 2.9 7.9 2.8 2.4 2 0 0 2 2 2 0 Neurogenesis glycoprotein CENP-H PF05837.12 ETO25402.1 - 6 7.3 16.7 1.1 9.7 4.2 2.6 2 0 0 2 2 2 0 Centromere protein H (CENP-H) DASH_Dam1 PF08653.10 ETO25402.1 - 7.4 6.5 7.7 30 4.5 0.2 3.3 3 0 0 3 3 3 0 DASH complex subunit Dam1 Nsp1_C PF05064.13 ETO25402.1 - 8.9 6.1 16.3 0.52 10.1 5.9 2.3 2 0 0 2 2 2 0 Nsp1-like C-terminal region WD40 PF00400.32 ETO25404.1 - 1.2e-43 146.2 23.1 4e-10 40.1 0.1 7.0 6 1 0 6 6 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25404.1 - 5e-22 78.0 2.0 0.00027 21.2 0.0 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25404.1 - 1.3e-13 50.7 0.3 0.065 12.2 0.0 5.1 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO25404.1 - 4.8e-08 32.7 4.1 0.52 10.3 0.0 5.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO25404.1 - 7.2e-07 28.8 0.1 0.032 13.5 0.0 3.1 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO25404.1 - 5.5e-06 25.3 1.9 0.38 9.4 0.0 4.8 2 1 3 5 5 5 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO25404.1 - 0.00016 20.3 0.4 0.56 8.7 0.0 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO25404.1 - 0.0014 18.7 0.6 7.2 6.7 0.0 4.1 1 1 4 5 5 5 1 Family of unknown function (DUF5570) DUF2963 PF11178.8 ETO25404.1 - 0.0029 17.3 0.1 1.7 8.4 0.0 3.4 2 1 0 2 2 2 1 Protein of unknown function (DUF2963) Proteasome_A_N PF10584.9 ETO25404.1 - 0.004 16.8 5.3 5.8 6.7 0.0 4.3 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Ret2_MD PF18528.1 ETO25404.1 - 0.0058 17.0 0.2 1.8 9.0 0.0 3.7 3 2 1 4 4 3 1 RNA editing 3' terminal uridylyl transferase 2 middle domain PALB2_WD40 PF16756.5 ETO25404.1 - 0.01 14.8 1.8 0.05 12.5 0.0 2.8 1 1 2 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Coatomer_WDAD PF04053.14 ETO25404.1 - 0.022 13.8 0.8 0.77 8.7 0.0 2.6 1 1 2 3 3 3 0 Coatomer WD associated region nos_propeller PF18764.1 ETO25404.1 - 0.025 14.5 0.0 8.7 6.3 0.0 3.8 4 1 0 4 4 4 0 Nitrous oxide reductase propeller repeat Nucleoporin_N PF08801.11 ETO25404.1 - 0.029 13.1 3.7 0.15 10.8 0.4 3.1 1 1 1 3 3 3 0 Nup133 N terminal like PQQ_2 PF13360.6 ETO25404.1 - 0.089 12.4 0.0 0.37 10.3 0.0 2.0 2 0 0 2 2 2 0 PQQ-like domain Me-amine-dh_H PF06433.11 ETO25404.1 - 0.1 11.4 0.0 0.29 9.9 0.0 1.7 1 1 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) Kelch_4 PF13418.6 ETO25405.1 - 3.3e-05 23.8 0.1 0.0035 17.3 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO25405.1 - 0.00014 22.0 0.6 0.0026 18.0 0.1 2.3 1 1 1 2 2 2 1 Kelch motif TPH PF13868.6 ETO25405.1 - 0.00018 20.1 83.7 0.00018 20.1 83.7 3.4 3 1 0 3 3 3 1 Trichohyalin-plectin-homology domain Orbi_NS1 PF01718.16 ETO25405.1 - 0.0086 14.6 4.5 0.014 13.9 4.5 1.2 1 0 0 1 1 1 1 Orbivirus non-structural protein NS1, or hydrophobic tubular protein Kelch_2 PF07646.15 ETO25405.1 - 0.023 14.6 0.2 0.23 11.5 0.1 2.4 2 0 0 2 2 2 0 Kelch motif Tox-HNH-HHH PF15637.6 ETO25405.1 - 0.054 13.7 3.6 0.15 12.3 0.7 3.0 2 1 0 2 2 2 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif Kelch_1 PF01344.25 ETO25405.1 - 0.092 12.3 0.3 1.2 8.8 0.3 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO25405.1 - 0.34 11.0 1.3 15 5.7 1.5 2.4 2 0 0 2 2 2 0 Kelch motif DOG1 PF14144.6 ETO25405.1 - 2.4 8.4 4.7 0.94 9.7 0.9 2.4 2 1 0 2 2 2 0 Seed dormancy control WD40 PF00400.32 ETO25406.1 - 5e-53 175.9 17.6 4.7e-10 39.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25406.1 - 9.8e-23 80.3 1.2 0.00083 19.6 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO25406.1 - 2.9e-12 46.9 0.9 0.0018 18.2 0.0 4.0 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO25406.1 - 6.1e-11 41.9 0.9 0.048 12.6 0.0 6.0 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO25406.1 - 1e-09 38.1 6.5 0.092 12.7 0.0 6.3 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO25406.1 - 1.2e-08 33.9 1.0 0.0001 21.0 0.0 3.4 1 1 2 4 4 4 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO25406.1 - 3.1e-07 30.0 0.0 0.00047 19.6 0.0 3.6 2 1 2 4 4 4 1 WD40-like domain Coatomer_WDAD PF04053.14 ETO25406.1 - 3.3e-05 23.1 0.3 0.0039 16.3 0.1 2.1 1 1 0 2 2 2 2 Coatomer WD associated region Proteasome_A_N PF10584.9 ETO25406.1 - 0.00023 20.8 4.1 5.8 6.7 0.0 4.8 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Nup160 PF11715.8 ETO25406.1 - 0.00049 18.9 6.7 2 7.0 0.1 4.0 1 1 2 4 4 4 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO25406.1 - 0.00055 19.4 0.9 1.7 7.9 0.1 3.6 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO25406.1 - 0.00069 18.8 0.0 0.34 9.9 0.0 3.0 2 1 2 4 4 4 1 VID27 C-terminal WD40-like domain NHL PF01436.21 ETO25406.1 - 0.0046 16.9 0.5 2 8.6 0.0 3.4 4 0 0 4 4 3 1 NHL repeat PQQ PF01011.21 ETO25406.1 - 0.018 15.0 0.0 4 7.5 0.0 3.0 2 0 0 2 2 2 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO25406.1 - 0.046 12.5 5.5 3.3 6.3 0.4 3.6 1 1 1 2 2 2 0 Nup133 N terminal like GSDH PF07995.11 ETO25406.1 - 0.072 12.4 0.0 6.7 5.9 0.0 2.8 1 1 2 3 3 3 0 Glucose / Sorbosone dehydrogenase Phi29_Phage_SSB PF17427.2 ETO25406.1 - 0.081 13.1 0.0 0.74 10.0 0.0 2.2 2 0 0 2 2 2 0 Phage Single-stranded DNA-binding protein SBDS PF01172.18 ETO25407.1 - 5.1e-22 77.8 0.6 9.8e-22 76.8 0.0 1.8 2 0 0 2 2 2 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein SBDS_C PF09377.10 ETO25407.1 - 7.7e-16 58.2 0.0 1.4e-15 57.3 0.0 1.4 1 0 0 1 1 1 1 SBDS protein C-terminal domain PPO1_KFDV PF12143.8 ETO25409.1 - 0.24 11.5 4.7 0.3 11.2 4.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) DUF515 PF04415.12 ETO25409.1 - 0.76 8.1 10.6 0.93 7.8 10.6 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) Borrelia_P83 PF05262.11 ETO25409.1 - 9.5 4.6 19.8 11 4.4 19.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein CAML PF14963.6 ETO25411.1 - 0.75 9.9 9.8 0.97 9.5 9.8 1.1 1 0 0 1 1 1 0 Calcium signal-modulating cyclophilin ligand DUF4407 PF14362.6 ETO25411.1 - 0.96 8.7 5.6 1.1 8.5 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GET2 PF08690.10 ETO25411.1 - 1.6 8.4 8.7 1.9 8.1 8.7 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 YlqD PF11068.8 ETO25411.1 - 3.7 7.9 10.3 0.35 11.3 5.2 1.8 1 1 1 2 2 2 0 YlqD protein Presenilin PF01080.17 ETO25411.1 - 7.3 5.2 8.2 8.1 5.1 8.2 1.1 1 0 0 1 1 1 0 Presenilin BUD22 PF09073.10 ETO25412.1 - 0.65 9.3 23.5 1.2 8.4 23.5 1.4 1 0 0 1 1 1 0 BUD22 VIR_N PF15912.5 ETO25412.1 - 3 7.4 12.0 4.9 6.7 12.0 1.3 1 0 0 1 1 1 0 Virilizer, N-terminal Nop14 PF04147.12 ETO25412.1 - 5.8 5.0 27.6 9.2 4.3 27.6 1.2 1 0 0 1 1 1 0 Nop14-like family WD40 PF00400.32 ETO25413.1 - 0.0068 17.2 0.0 0.054 14.4 0.0 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat Kelch_5 PF13854.6 ETO25414.1 - 9.5e-07 28.7 14.6 0.051 13.6 0.1 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO25414.1 - 6.6e-06 25.9 6.0 1 9.5 0.0 5.5 5 0 0 5 5 5 1 Kelch motif DUF4834 PF16118.5 ETO25414.1 - 6.9e-06 26.9 1.4 6.9e-06 26.9 1.4 3.7 1 1 2 3 3 3 1 Domain of unknown function (DUF4834) Kelch_4 PF13418.6 ETO25414.1 - 0.0014 18.6 8.3 0.36 10.9 0.0 4.9 6 0 0 6 6 6 1 Galactose oxidase, central domain LYRIC PF15686.5 ETO25414.1 - 0.009 15.6 11.8 0.009 15.6 11.8 2.1 1 1 1 2 2 2 1 Lysine-rich CEACAM1 co-isolated protein family SRTM1 PF15872.5 ETO25414.1 - 0.035 14.3 0.3 0.088 13.0 0.3 1.6 1 0 0 1 1 1 0 Serine-rich and transmembrane domain-containing protein 1 Kelch_1 PF01344.25 ETO25414.1 - 0.054 13.1 0.2 0.054 13.1 0.2 4.5 5 0 0 5 5 5 0 Kelch motif Glycophorin_A PF01102.18 ETO25414.1 - 0.078 13.2 0.0 0.23 11.7 0.0 1.8 1 0 0 1 1 1 0 Glycophorin A DUF4083 PF13314.6 ETO25414.1 - 0.18 11.7 0.7 0.5 10.4 0.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) Kelch_6 PF13964.6 ETO25414.1 - 2.7 8.4 16.9 18 5.8 0.3 5.4 5 2 1 6 6 6 0 Kelch motif GDP_Man_Dehyd PF16363.5 ETO25415.1 - 3.7e-22 79.2 0.0 8.5e-22 78.0 0.0 1.5 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETO25415.1 - 6.9e-22 78.1 0.0 9.7e-22 77.6 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ETO25415.1 - 1.9e-13 50.2 0.0 3e-13 49.6 0.0 1.3 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein 3Beta_HSD PF01073.19 ETO25415.1 - 1e-12 47.7 0.1 1.7e-12 47.0 0.1 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETO25415.1 - 3.1e-05 23.2 0.0 0.0001 21.5 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ETO25415.1 - 0.0097 15.1 0.0 0.089 11.9 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 ETO25415.1 - 0.042 14.1 0.0 0.08 13.2 0.0 1.5 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain KR PF08659.10 ETO25415.1 - 0.043 13.7 0.0 0.12 12.3 0.0 1.8 1 1 0 1 1 1 0 KR domain Ubiquitin_2 PF14560.6 ETO25416.1 - 0.077 13.5 0.2 0.14 12.6 0.2 1.4 1 0 0 1 1 1 0 Ubiquitin-like domain DUF4366 PF14283.6 ETO25417.1 - 0.04 14.0 0.5 0.078 13.0 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) Dor1 PF04124.12 ETO25417.1 - 0.1 11.3 7.5 0.13 10.9 7.5 1.2 1 0 0 1 1 1 0 Dor1-like family HAP1_N PF04849.13 ETO25418.1 - 0.017 14.3 14.0 0.014 14.7 11.9 1.8 2 0 0 2 2 2 0 HAP1 N-terminal conserved region YabA PF06156.13 ETO25418.1 - 0.35 11.5 7.2 0.45 11.2 5.5 2.1 1 1 0 1 1 1 0 Initiation control protein YabA SelK_SelG PF10961.8 ETO25419.1 - 0.1 13.2 0.6 0.18 12.5 0.6 1.4 1 1 0 1 1 1 0 Selenoprotein SelK_SelG SlyX PF04102.12 ETO25420.1 - 0.71 10.5 10.5 0.34 11.6 1.6 2.3 2 0 0 2 2 2 0 SlyX STAG PF08514.11 ETO25420.1 - 1.3 8.9 5.0 35 4.4 0.0 2.4 2 0 0 2 2 2 0 STAG domain DUF4140 PF13600.6 ETO25420.1 - 9.9 6.7 6.0 30 5.1 1.2 2.2 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) Pex24p PF06398.11 ETO25421.1 - 0.0039 16.2 0.1 0.0061 15.6 0.1 1.3 1 0 0 1 1 1 1 Integral peroxisomal membrane peroxin Peptidase_S49_N PF08496.10 ETO25421.1 - 0.28 11.2 11.8 2 8.5 1.0 2.5 1 1 1 2 2 2 0 Peptidase family S49 N-terminal SID-1_RNA_chan PF13965.6 ETO25421.1 - 0.41 9.0 16.9 1.1 7.6 16.9 1.7 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Colicin PF01024.19 ETO25421.1 - 0.65 9.9 5.6 3.7 7.4 0.0 2.2 2 0 0 2 2 2 0 Colicin pore forming domain Shisa PF13908.6 ETO25421.1 - 1.8 8.8 12.2 0.13 12.5 6.5 2.0 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator FAM76 PF16046.5 ETO25421.1 - 2.9 7.1 18.1 4.3 6.6 18.1 1.2 1 0 0 1 1 1 0 FAM76 protein RRM_1 PF00076.22 ETO25422.1 - 0.002 17.9 0.0 0.0049 16.7 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DnaJ-X PF14308.6 ETO25423.1 - 0.15 11.5 5.2 0.19 11.1 2.1 2.1 2 0 0 2 2 2 0 X-domain of DnaJ-containing SurA_N_3 PF13624.6 ETO25424.1 - 0.016 15.0 1.8 0.041 13.7 1.8 1.7 1 0 0 1 1 1 0 SurA N-terminal domain IF-2B PF01008.17 ETO25424.1 - 1.2 8.3 6.2 0.17 11.1 1.2 1.9 1 1 1 2 2 2 0 Initiation factor 2 subunit family Arteri_Gl PF00951.18 ETO25426.1 - 0.23 11.3 2.9 0.48 10.2 2.9 1.5 1 0 0 1 1 1 0 Arterivirus GL envelope glycoprotein DUF928 PF06051.12 ETO25427.1 - 0.12 12.3 0.1 0.19 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF928) Ank_2 PF12796.7 ETO25428.1 - 2e-07 31.5 0.0 3.5e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO25428.1 - 1.4e-05 25.5 0.0 0.22 12.1 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO25428.1 - 0.00073 19.8 0.1 2.2 9.1 0.0 2.5 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ETO25428.1 - 0.0043 17.4 0.0 0.73 10.4 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeat YL1 PF05764.13 ETO25428.1 - 3.9 7.5 9.2 0.4 10.8 4.9 1.5 2 0 0 2 2 2 0 YL1 nuclear protein FAM176 PF14851.6 ETO25428.1 - 8.6 6.0 6.4 16 5.2 6.4 1.5 1 0 0 1 1 1 0 FAM176 family 7tm_1 PF00001.21 ETO25429.1 - 0.039 13.3 2.5 0.083 12.2 2.5 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Peptidase_C14 PF00656.22 ETO25430.1 - 1.4e-12 48.2 1.0 2.8e-12 47.1 1.0 1.4 1 1 0 1 1 1 1 Caspase domain UCH PF00443.29 ETO25430.1 - 0.0085 15.6 0.2 0.015 14.8 0.2 1.4 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DASH_Spc19 PF08287.11 ETO25431.1 - 0.005 16.7 7.4 0.0075 16.2 7.4 1.2 1 0 0 1 1 1 1 Spc19 SDA1 PF05285.12 ETO25431.1 - 0.011 15.2 9.1 0.01 15.3 9.1 1.1 1 0 0 1 1 1 0 SDA1 CNDH2_C PF16858.5 ETO25431.1 - 0.026 14.4 7.0 0.032 14.1 7.0 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PI3K_1B_p101 PF10486.9 ETO25431.1 - 0.096 10.5 6.3 0.1 10.4 6.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Macoilin PF09726.9 ETO25431.1 - 0.37 9.3 6.8 0.38 9.2 6.8 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO25431.1 - 0.63 8.7 4.8 0.69 8.6 4.8 1.2 1 0 0 1 1 1 0 Presenilin TFIIA PF03153.13 ETO25431.1 - 0.74 9.7 15.2 0.95 9.4 15.2 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RR_TM4-6 PF06459.12 ETO25431.1 - 1.9 8.2 9.1 2.4 7.9 9.1 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 NPR3 PF03666.13 ETO25431.1 - 2 7.1 9.2 2.4 6.8 9.2 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2076 PF09849.9 ETO25431.1 - 3.6 7.5 16.2 4.9 7.1 16.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CDC45 PF02724.14 ETO25431.1 - 4.5 5.5 12.0 5.4 5.2 12.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Mucin PF01456.17 ETO25432.1 - 0.036 14.1 12.7 0.07 13.1 12.7 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein PBP1_TM PF14812.6 ETO25432.1 - 0.1 13.0 0.0 0.1 13.0 0.0 4.6 3 1 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Rtf2 PF04641.12 ETO25433.1 - 0.054 12.9 6.5 0.056 12.8 6.5 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger 7tm_3 PF00003.22 ETO25434.1 - 1.1e-30 107.2 28.6 1.6e-30 106.6 28.6 1.2 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Chlam_PMP PF02415.17 ETO25434.1 - 0.00017 21.9 48.3 1.1 9.9 0.1 12.5 14 0 0 14 14 14 5 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Pkinase PF00069.25 ETO25435.1 - 4e-21 75.6 0.0 4.9e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25435.1 - 7e-17 61.6 0.0 8.2e-17 61.3 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO25435.1 - 0.00045 19.6 0.3 0.0014 18.0 0.3 1.7 1 1 0 1 1 1 1 Kinase-like ABC2_membrane PF01061.24 ETO25436.1 - 4.9e-21 75.1 9.8 4.9e-21 75.1 9.8 2.0 1 1 1 2 2 2 1 ABC-2 type transporter Orf78 PF06024.12 ETO25436.1 - 1.2 9.5 7.6 0.28 11.5 0.7 2.3 2 0 0 2 2 2 0 Orf78 (ac78) YdjM PF04307.14 ETO25436.1 - 2.6 7.3 9.2 0.058 12.7 0.9 2.1 2 1 0 2 2 2 0 LexA-binding, inner membrane-associated putative hydrolase ABC2_membrane_3 PF12698.7 ETO25437.1 - 0.0011 18.2 5.1 0.0017 17.5 5.1 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein Orf78 PF06024.12 ETO25437.1 - 0.0017 18.7 7.2 0.0017 18.7 7.2 2.2 2 0 0 2 2 2 1 Orf78 (ac78) AgrB PF04647.15 ETO25437.1 - 0.0047 16.3 11.7 0.011 15.0 11.7 1.5 1 0 0 1 1 1 1 Accessory gene regulator B DUF1676 PF07898.13 ETO25437.1 - 0.013 15.6 1.3 0.024 14.7 1.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1676) T2SSF PF00482.23 ETO25437.1 - 0.013 15.4 2.6 0.027 14.4 2.6 1.5 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein F DUF4448 PF14610.6 ETO25437.1 - 0.092 12.5 3.5 0.14 12.0 3.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF4448) DUF2207 PF09972.9 ETO25437.1 - 0.13 11.0 7.3 0.19 10.5 7.3 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Shisa PF13908.6 ETO25437.1 - 0.4 10.9 13.5 0.073 13.3 7.2 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator DUF5383 PF17355.2 ETO25437.1 - 0.73 10.2 11.8 3.1 8.2 11.9 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5383) TMEM154 PF15102.6 ETO25437.1 - 1.2 9.0 21.3 0.24 11.3 16.2 2.0 1 1 0 2 2 2 0 TMEM154 protein family DUF4736 PF15883.5 ETO25437.1 - 1.3 8.7 8.6 0.25 11.0 1.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4736) Renin_r PF07850.14 ETO25437.1 - 1.5 9.4 11.9 0.88 10.2 5.8 2.2 2 0 0 2 2 2 0 Renin receptor-like protein Sigma_reg_N PF13800.6 ETO25437.1 - 1.7 9.0 17.7 2.3 8.6 16.0 2.1 2 0 0 2 2 2 0 Sigma factor regulator N-terminal NT-C2 PF10358.9 ETO25439.1 - 6.8e-06 25.9 0.3 8.4e-06 25.6 0.3 1.1 1 0 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins IL3Ra_N PF18611.1 ETO25439.1 - 0.07 13.1 0.2 0.14 12.2 0.2 1.5 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain Phage_Gp23 PF10669.9 ETO25439.1 - 0.36 11.2 4.1 0.64 10.4 4.1 1.4 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) TPR_MLP1_2 PF07926.12 ETO25440.1 - 0.0041 17.2 9.6 0.0041 17.2 9.6 3.2 2 1 0 3 3 3 1 TPR/MLP1/MLP2-like protein WEMBL PF05701.11 ETO25440.1 - 0.05 12.3 23.1 0.077 11.7 23.1 1.2 1 0 0 1 1 1 0 Weak chloroplast movement under blue light Ribosomal_L40e PF01020.17 ETO25440.1 - 0.072 13.0 4.1 0.21 11.5 4.1 1.9 1 0 0 1 1 1 0 Ribosomal L40e family Herpes_BLRF2 PF05812.12 ETO25440.1 - 0.46 10.6 16.8 0.18 11.9 1.7 3.5 2 1 1 3 3 3 0 Herpesvirus BLRF2 protein BRE1 PF08647.11 ETO25440.1 - 0.55 10.3 36.8 0.44 10.7 14.4 3.9 2 1 1 3 3 3 0 BRE1 E3 ubiquitin ligase APG6_N PF17675.1 ETO25440.1 - 0.76 10.3 36.1 0.55 10.8 17.2 3.2 1 1 1 2 2 2 0 Apg6 coiled-coil region Golgin_A5 PF09787.9 ETO25440.1 - 3.1 7.2 32.7 0.23 10.9 28.0 1.4 2 0 0 2 2 2 0 Golgin subfamily A member 5 ATG16 PF08614.11 ETO25440.1 - 4.7 7.4 34.5 0.98 9.6 26.3 2.8 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) LMBR1 PF04791.16 ETO25440.1 - 5.7 5.7 12.6 7.7 5.3 12.6 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF812 PF05667.11 ETO25440.1 - 7.6 5.3 32.0 3.2 6.5 11.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF812) CENP-F_leu_zip PF10473.9 ETO25440.1 - 7.8 6.5 39.2 0.18 11.8 11.6 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Efg1 PF10153.9 ETO25441.1 - 0.0073 16.7 3.5 0.0073 16.7 3.5 1.5 1 1 0 1 1 1 1 rRNA-processing protein Efg1 ESM4 PF15952.5 ETO25441.1 - 0.018 15.5 4.8 0.019 15.4 4.3 1.3 1 1 0 1 1 1 0 Enhancer of split M4 family TIM PF00121.18 ETO25441.1 - 0.037 13.4 1.9 0.056 12.8 1.8 1.3 1 1 0 1 1 1 0 Triosephosphate isomerase BLOC1_2 PF10046.9 ETO25441.1 - 0.04 14.2 4.9 2.9 8.3 1.6 2.6 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 FlaC_arch PF05377.11 ETO25441.1 - 0.082 13.3 1.6 3.8 8.0 0.1 2.6 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Noelin-1 PF12308.8 ETO25441.1 - 0.083 12.9 2.5 1.5 8.8 0.1 2.5 1 1 2 3 3 3 0 Neurogenesis glycoprotein DUF1664 PF07889.12 ETO25441.1 - 0.19 11.8 2.5 0.37 10.9 1.2 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) zf-CCHC PF00098.23 ETO25442.1 - 0.017 15.2 2.2 0.04 14.0 2.2 1.6 1 0 0 1 1 1 0 Zinc knuckle Trypan_PARP PF05887.11 ETO25442.1 - 1.2 9.2 13.4 2 8.4 13.4 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) LAP1C PF05609.12 ETO25442.1 - 2 7.4 19.0 3 6.9 19.0 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GCV_T PF01571.21 ETO25443.1 - 7.8e-82 274.5 0.0 1.2e-81 273.9 0.0 1.3 1 0 0 1 1 1 1 Aminomethyltransferase folate-binding domain GCV_T_C PF08669.11 ETO25443.1 - 1.8e-17 63.1 0.0 3e-17 62.3 0.0 1.4 1 0 0 1 1 1 1 Glycine cleavage T-protein C-terminal barrel domain WD40 PF00400.32 ETO25443.1 - 0.00032 21.4 2.6 0.38 11.7 0.3 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat B2-adapt-app_C PF09066.10 ETO25444.1 - 2.6e-18 66.2 0.0 3.2e-18 65.8 0.0 1.1 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain Peptidase_C14 PF00656.22 ETO25447.1 - 8.5e-14 52.1 0.4 1.4e-13 51.4 0.4 1.2 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO25449.1 - 0.0077 16.2 1.9 1.8 8.6 0.1 4.0 4 0 0 4 4 4 1 Kelch motif XPA_C PF05181.12 ETO25449.1 - 0.022 14.7 0.2 0.063 13.2 0.0 1.8 2 0 0 2 2 2 0 XPA protein C-terminus Kelch_6 PF13964.6 ETO25449.1 - 0.11 12.8 1.6 4.2 7.8 0.1 3.0 2 0 0 2 2 2 0 Kelch motif DUF2272 PF10030.9 ETO25449.1 - 0.2 11.4 0.1 0.43 10.3 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2272) WD40 PF00400.32 ETO25450.1 - 8.8e-77 251.1 20.0 1.7e-10 41.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25450.1 - 6e-19 68.1 3.5 0.017 15.4 0.0 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25450.1 - 1.8e-18 66.6 0.4 0.0017 17.4 0.0 7.0 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO25450.1 - 3e-08 33.4 1.1 0.0026 17.1 0.2 3.6 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO25450.1 - 1.9e-07 30.1 5.2 0.46 9.1 0.0 5.9 2 1 3 6 6 6 3 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO25450.1 - 9.6e-06 25.6 0.1 1 9.5 0.0 4.2 2 2 2 4 4 4 2 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO25450.1 - 4.1e-05 22.3 1.1 1.5 7.2 0.0 3.8 1 1 2 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO25450.1 - 0.001 19.0 8.4 4.3 7.4 0.0 6.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO25450.1 - 0.0025 17.4 0.1 13 5.5 0.1 4.1 4 0 0 4 4 4 1 HepA-related protein (HARP) DUF1002 PF06207.11 ETO25450.1 - 0.024 14.2 1.0 0.038 13.5 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Big_7 PF17957.1 ETO25450.1 - 2.8 8.8 4.6 40 5.1 0.0 3.5 4 1 1 5 5 4 0 Bacterial Ig domain EF-hand_1 PF00036.32 ETO25451.1 - 0.094 12.3 0.1 0.094 12.3 0.1 2.2 2 0 0 2 2 2 0 EF hand ECH_1 PF00378.20 ETO25452.1 - 3e-24 85.7 0.1 3.9e-24 85.3 0.1 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO25452.1 - 8.2e-19 68.3 0.0 1e-18 67.9 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase tRNA_U5-meth_tr PF05958.11 ETO25453.1 - 1.2e-10 40.9 0.0 2.3e-10 40.0 0.0 1.4 1 0 0 1 1 1 1 tRNA (Uracil-5-)-methyltransferase Methyltransf_31 PF13847.6 ETO25453.1 - 5e-08 32.9 0.1 1.1e-07 31.8 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO25453.1 - 0.00046 20.9 0.0 0.0017 19.0 0.0 2.0 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ETO25453.1 - 0.0028 17.2 0.0 0.0049 16.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain Ubie_methyltran PF01209.18 ETO25453.1 - 0.028 13.8 0.0 0.044 13.1 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ETO25453.1 - 0.074 12.5 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Putative methyltransferase Mannitol_dh_C PF08125.13 ETO25453.1 - 0.098 12.1 0.0 1.4 8.3 0.0 2.2 2 0 0 2 2 2 0 Mannitol dehydrogenase C-terminal domain XK-related PF09815.9 ETO25454.1 - 0.0016 17.6 17.6 0.0024 17.0 17.6 1.2 1 0 0 1 1 1 1 XK-related protein CcmF_C PF16327.5 ETO25454.1 - 0.11 11.7 6.4 0.25 10.6 6.4 1.5 1 0 0 1 1 1 0 Cytochrome c-type biogenesis protein CcmF C-terminal DUF5470 PF17564.2 ETO25454.1 - 0.41 10.9 2.8 1.2 9.4 2.8 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5470) Comm PF15957.5 ETO25454.1 - 3.5 8.0 5.1 7 7.0 2.5 2.8 2 0 0 2 2 2 0 Commissureless DUF4407 PF14362.6 ETO25455.1 - 0.00094 18.6 20.8 0.00094 18.6 20.8 2.1 1 1 1 2 2 2 1 Domain of unknown function (DUF4407) DUF2937 PF11157.8 ETO25455.1 - 0.12 12.0 3.6 0.71 9.6 0.0 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2937) G-alpha PF00503.20 ETO25456.1 - 1.5e-46 159.2 13.6 2.2e-46 158.6 13.6 1.4 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO25456.1 - 4.9e-07 29.4 1.9 3e-06 26.8 0.1 2.4 2 1 0 2 2 2 1 ADP-ribosylation factor family Roc PF08477.13 ETO25456.1 - 0.26 11.5 0.0 0.26 11.5 0.0 2.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FliJ PF02050.16 ETO25456.1 - 0.37 11.0 22.9 0.067 13.4 1.7 2.3 2 0 0 2 2 2 0 Flagellar FliJ protein Nkap_C PF06047.11 ETO25457.1 - 8.5e-46 154.3 2.5 8.5e-46 154.3 2.5 3.9 4 0 0 4 4 4 1 NF-kappa-B-activating protein C-terminal domain RUN PF02759.19 ETO25458.1 - 0.0072 16.3 1.5 0.014 15.3 0.0 2.2 3 0 0 3 3 3 1 RUN domain Cwf_Cwc_15 PF04889.12 ETO25458.1 - 0.07 12.9 26.4 0.11 12.2 26.4 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETO25458.1 - 0.086 11.1 16.4 0.11 10.8 16.4 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO25458.1 - 0.13 12.4 22.2 0.19 11.8 22.2 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Herpes_LMP1 PF05297.11 ETO25458.1 - 0.52 9.4 12.2 0.63 9.2 12.2 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) zf-RING_9 PF13901.6 ETO25459.1 - 2.7e-44 151.6 22.8 2.7e-44 151.6 22.8 1.9 2 0 0 2 2 2 1 Putative zinc-RING and/or ribbon TF_Zn_Ribbon PF08271.12 ETO25459.1 - 0.012 15.1 3.5 0.012 15.1 3.5 2.2 2 0 0 2 2 2 0 TFIIB zinc-binding C1_1 PF00130.22 ETO25459.1 - 6.5 6.7 34.3 2.9 7.9 4.8 3.6 2 1 1 3 3 3 0 Phorbol esters/diacylglycerol binding domain (C1 domain) HALZ PF02183.18 ETO25460.1 - 2.4e-05 24.4 15.2 0.042 14.1 1.3 3.5 3 0 0 3 3 3 3 Homeobox associated leucine zipper ATG16 PF08614.11 ETO25460.1 - 0.048 13.9 31.7 0.069 13.4 31.7 1.2 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF2999 PF11212.8 ETO25460.1 - 0.082 13.2 3.9 0.1 12.9 2.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2999) GAS PF13851.6 ETO25460.1 - 0.19 11.0 34.4 0.57 9.5 7.8 3.1 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding TSC22 PF01166.18 ETO25460.1 - 0.23 11.8 16.4 1.3 9.4 3.4 3.9 3 1 1 4 4 4 0 TSC-22/dip/bun family ADIP PF11559.8 ETO25460.1 - 0.35 10.9 35.6 0.16 12.0 26.6 2.8 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding LRRFIP PF09738.9 ETO25460.1 - 1.3 8.4 31.0 0.55 9.7 19.0 2.3 1 1 1 2 2 2 0 LRRFIP family Rootletin PF15035.6 ETO25460.1 - 1.6 8.7 32.7 4.4 7.3 18.5 2.6 1 1 2 3 3 3 0 Ciliary rootlet component, centrosome cohesion HAP1_N PF04849.13 ETO25460.1 - 4.7 6.3 39.8 18 4.4 14.1 3.3 1 1 1 2 2 2 0 HAP1 N-terminal conserved region YabA PF06156.13 ETO25460.1 - 5.8 7.6 25.8 4.9 7.8 0.3 3.3 1 1 2 3 3 3 0 Initiation control protein YabA Spc7 PF08317.11 ETO25460.1 - 6.2 5.6 32.2 3.2 6.5 9.9 2.2 1 1 1 2 2 2 0 Spc7 kinetochore protein NYD-SP28_assoc PF14775.6 ETO25460.1 - 6.8 6.9 15.9 6.6 6.9 2.0 3.8 3 1 0 3 3 3 0 Sperm tail C-terminal domain TPR_MLP1_2 PF07926.12 ETO25460.1 - 7.5 6.6 35.0 3.6 7.7 9.0 2.8 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein Snapin_Pallidin PF14712.6 ETO25460.1 - 8.4 6.9 27.4 1.1 9.7 8.8 2.8 3 0 0 3 3 3 0 Snapin/Pallidin Endomucin PF07010.12 ETO25462.1 - 3.3 7.6 30.1 4 7.3 30.1 1.1 1 0 0 1 1 1 0 Endomucin Bcl-2 PF00452.19 ETO25463.1 - 0.051 14.3 0.7 0.37 11.5 0.1 2.0 1 1 1 2 2 2 0 Apoptosis regulator proteins, Bcl-2 family Peptidase_C14 PF00656.22 ETO25464.1 - 1.7e-11 44.6 0.5 2.6e-11 43.9 0.5 1.3 1 1 0 1 1 1 1 Caspase domain C2 PF00168.30 ETO25465.1 - 0.00027 21.2 0.3 0.00053 20.2 0.1 1.6 2 0 0 2 2 2 1 C2 domain Vma12 PF11712.8 ETO25466.1 - 0.01 15.9 3.8 0.015 15.4 3.8 1.3 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF720 PF05302.11 ETO25466.1 - 0.021 14.6 1.0 0.035 14.0 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF720) Amidase PF01425.21 ETO25466.1 - 0.12 11.3 0.6 0.14 11.1 0.6 1.1 1 0 0 1 1 1 0 Amidase Sec62 PF03839.16 ETO25466.1 - 0.74 9.3 7.1 1 8.8 7.1 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 PP28 PF10252.9 ETO25466.1 - 0.78 10.2 13.4 0.48 10.9 11.5 1.6 1 1 0 1 1 1 0 Casein kinase substrate phosphoprotein PP28 RRM_1 PF00076.22 ETO25468.1 - 9.6e-10 38.2 0.3 2.3e-08 33.7 0.0 2.9 2 1 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) AIP3 PF03915.13 ETO25469.1 - 2.6e-07 30.1 1.3 3.2e-07 29.8 1.3 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 RRM_1 PF00076.22 ETO25469.1 - 0.029 14.2 0.1 0.11 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pox_E10 PF04805.12 ETO25469.1 - 0.044 13.6 0.5 0.11 12.4 0.1 2.0 2 0 0 2 2 2 0 E10-like protein conserved region UN_NPL4 PF11543.8 ETO25469.1 - 0.13 12.8 0.0 0.31 11.6 0.0 1.7 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 RRM_1 PF00076.22 ETO25470.1 - 0.0048 16.7 0.0 1.3 8.9 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Secretin_N_2 PF07655.13 ETO25470.1 - 2.8 8.6 19.6 0.69 10.5 9.1 2.8 2 0 0 2 2 2 0 Secretin N-terminal domain YqfQ PF14181.6 ETO25470.1 - 3.1 8.0 10.0 0.53 10.5 3.2 2.3 2 0 0 2 2 2 0 YqfQ-like protein NusB PF01029.18 ETO25471.1 - 0.37 11.0 3.0 0.39 11.0 0.6 2.0 1 1 1 2 2 2 0 NusB family Zip PF02535.22 ETO25471.1 - 0.4 9.9 2.0 0.66 9.1 2.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Kinesin PF00225.23 ETO25472.1 - 6.9e-44 150.1 0.1 1.3e-43 149.2 0.1 1.3 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO25472.1 - 3.1e-07 30.5 0.0 1.1e-06 28.6 0.0 2.0 2 0 0 2 2 2 1 Microtubule binding DUF2553 PF10830.8 ETO25473.1 - 0.25 12.2 4.0 0.19 12.6 1.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2553) Vir_act_alpha_C PF10400.9 ETO25473.1 - 8.2 7.2 8.9 9.3 7.0 0.6 4.2 2 1 1 4 4 4 0 Virulence activator alpha C-term Rtt106 PF08512.12 ETO25474.1 - 7.9e-22 77.5 0.0 3.4e-21 75.5 0.0 2.1 1 0 0 1 1 1 1 Histone chaperone Rttp106-like SSrecog PF03531.14 ETO25474.1 - 1.8e-14 53.4 0.2 6.2e-14 51.7 0.2 2.0 1 0 0 1 1 1 1 Structure-specific recognition protein (SSRP1) POB3_N PF17292.2 ETO25474.1 - 8.2e-12 45.4 1.1 9e-07 29.2 0.1 2.8 2 0 0 2 2 2 2 POB3-like N-terminal PH domain PH_TFIIH PF08567.11 ETO25474.1 - 0.0083 16.4 0.1 0.063 13.6 0.0 2.5 3 0 0 3 3 3 1 TFIIH p62 subunit, N-terminal domain Sulfatase PF00884.23 ETO25475.1 - 1.8e-19 70.3 0.5 3.3e-19 69.4 0.1 1.5 2 0 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 ETO25475.1 - 3.4e-05 24.1 0.3 0.0001 22.5 0.0 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4976) Phosphodiest PF01663.22 ETO25475.1 - 0.036 13.7 0.1 0.062 12.9 0.1 1.3 1 0 0 1 1 1 0 Type I phosphodiesterase / nucleotide pyrophosphatase CNDH2_M PF16869.5 ETO25476.1 - 0.12 13.1 3.4 0.14 12.8 3.4 1.2 1 0 0 1 1 1 0 PF16858 DUF4614 PF15391.6 ETO25476.1 - 1.6 8.7 13.1 1.9 8.4 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Connexin PF00029.19 ETO25476.1 - 2.1 8.1 5.0 2.3 7.9 5.0 1.2 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO25476.1 - 3 6.5 8.1 3 6.5 8.1 1.0 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO25476.1 - 7.6 5.6 9.3 8.5 5.5 9.3 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RhoGAP PF00620.27 ETO25477.1 - 2.6e-16 59.8 0.0 3.5e-14 52.9 0.0 2.4 1 1 0 1 1 1 1 RhoGAP domain PBD PF00786.28 ETO25477.1 - 0.024 15.0 0.0 0.13 12.6 0.0 2.4 1 1 0 1 1 1 0 P21-Rho-binding domain Peptidase_M50 PF02163.22 ETO25477.1 - 0.14 11.4 0.2 0.3 10.3 0.1 1.5 2 0 0 2 2 2 0 Peptidase family M50 Myc_N PF01056.18 ETO25478.1 - 0.28 11.1 2.5 0.37 10.6 2.5 1.1 1 0 0 1 1 1 0 Myc amino-terminal region SlyX PF04102.12 ETO25478.1 - 0.39 11.4 5.7 0.24 12.1 3.9 1.6 1 1 0 1 1 1 0 SlyX DUF2345 PF10106.9 ETO25479.1 - 4e-17 62.5 0.1 0.68 9.8 0.0 8.5 2 2 6 8 8 8 8 Uncharacterized protein conserved in bacteria (DUF2345) Gp5_C PF06715.12 ETO25479.1 - 4.1e-07 29.7 99.1 0.021 15.0 1.6 14.9 12 3 2 16 16 16 10 Gp5 C-terminal repeat (3 copies) PT PF04886.12 ETO25480.1 - 3.5e-09 36.1 50.7 2.9e-06 26.7 7.6 5.4 3 1 2 5 5 5 3 PT repeat Glycoprotein_G PF00802.19 ETO25480.1 - 1.3 8.3 27.5 3 7.1 27.5 1.7 1 1 0 1 1 1 0 Pneumovirus attachment glycoprotein G LCM PF04072.14 ETO25482.1 - 2.7e-15 56.8 0.0 6.9e-15 55.5 0.0 1.7 1 1 0 1 1 1 1 Leucine carboxyl methyltransferase Actin PF00022.19 ETO25482.1 - 0.18 10.4 0.0 0.24 10.0 0.0 1.1 1 0 0 1 1 1 0 Actin Spt20 PF12090.8 ETO25483.1 - 0.00029 20.6 7.1 0.00036 20.2 7.1 1.1 1 0 0 1 1 1 1 Spt20 family Ureide_permease PF07168.11 ETO25483.1 - 0.0027 16.5 3.3 0.0033 16.3 3.3 1.1 1 0 0 1 1 1 1 Ureide permease FAM176 PF14851.6 ETO25483.1 - 0.0036 17.0 3.2 0.0058 16.3 3.2 1.3 1 0 0 1 1 1 1 FAM176 family DUF2201_N PF13203.6 ETO25483.1 - 0.0069 16.0 0.6 0.0085 15.7 0.6 1.1 1 0 0 1 1 1 1 Putative metallopeptidase domain Myc_N PF01056.18 ETO25483.1 - 0.0089 16.0 4.9 0.0095 15.9 4.9 1.1 1 0 0 1 1 1 1 Myc amino-terminal region Gti1_Pac2 PF09729.9 ETO25483.1 - 0.01 16.0 4.2 0.012 15.7 4.2 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family DDHD PF02862.17 ETO25483.1 - 0.011 15.9 2.7 0.012 15.8 2.7 1.1 1 0 0 1 1 1 0 DDHD domain RNA_pol_Rpc4 PF05132.14 ETO25483.1 - 0.017 15.6 2.5 0.021 15.3 2.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 AAA_15 PF13175.6 ETO25483.1 - 0.023 14.4 11.9 0.027 14.2 11.9 1.1 1 0 0 1 1 1 0 AAA ATPase domain RP-C_C PF11800.8 ETO25483.1 - 0.025 14.7 2.6 0.027 14.6 2.6 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Kei1 PF08552.11 ETO25483.1 - 0.03 14.2 1.1 0.042 13.7 1.1 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 SID-1_RNA_chan PF13965.6 ETO25483.1 - 0.038 12.4 4.3 0.043 12.2 4.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 SLC12 PF03522.15 ETO25483.1 - 0.041 12.9 7.4 0.045 12.8 7.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO25483.1 - 0.045 12.1 6.9 0.046 12.0 6.9 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 ETO25483.1 - 0.048 13.1 8.1 0.054 12.9 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Zip PF02535.22 ETO25483.1 - 0.057 12.6 5.2 0.064 12.5 5.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 ETO25483.1 - 0.065 12.2 2.5 0.077 11.9 2.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Neur_chan_memb PF02932.16 ETO25483.1 - 0.083 12.9 1.4 0.081 13.0 1.4 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 ETO25483.1 - 0.09 11.6 8.9 0.1 11.3 8.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO25483.1 - 0.11 11.3 9.2 0.13 11.0 9.2 1.1 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 ETO25483.1 - 0.22 10.5 4.6 0.28 10.2 4.6 1.1 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 ETO25483.1 - 0.33 10.7 2.6 0.47 10.2 2.6 1.3 1 0 0 1 1 1 0 Connexin DUF4820 PF16091.5 ETO25483.1 - 0.56 9.5 7.2 0.71 9.2 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EOS1 PF12326.8 ETO25483.1 - 0.83 9.6 3.7 1.1 9.2 3.7 1.2 1 0 0 1 1 1 0 N-glycosylation protein Serinc PF03348.15 ETO25483.1 - 1 8.2 4.3 1.3 7.9 4.3 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) Tim54 PF11711.8 ETO25483.1 - 1 8.0 10.7 1.4 7.6 10.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ALMT PF11744.8 ETO25483.1 - 1.8 7.3 7.4 2.1 7.1 7.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Membralin PF09746.9 ETO25483.1 - 1.8 7.5 6.5 2.2 7.2 6.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Sec62 PF03839.16 ETO25483.1 - 1.8 8.0 8.9 2.4 7.6 8.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Menin PF05053.13 ETO25483.1 - 4.5 5.5 10.1 5.5 5.2 10.1 1.1 1 0 0 1 1 1 0 Menin O-antigen_lig PF13425.6 ETO25483.1 - 4.6 5.9 5.4 5.6 5.6 5.4 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein NOA36 PF06524.12 ETO25486.1 - 0.36 10.1 7.9 0.65 9.3 7.9 1.4 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO25486.1 - 2.5 6.2 12.6 3.3 5.8 12.6 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO25486.1 - 5.7 6.2 17.0 9.3 5.5 17.0 1.3 1 0 0 1 1 1 0 BUD22 Anoctamin PF04547.12 ETO25487.1 - 5.5e-98 328.7 9.2 7.2e-98 328.3 9.2 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoct_dimer PF16178.5 ETO25487.1 - 7.1e-05 22.6 0.4 0.00014 21.6 0.4 1.4 1 0 0 1 1 1 1 Dimerisation domain of Ca+-activated chloride-channel, anoctamin EMC3_TMCO1 PF01956.16 ETO25487.1 - 0.00048 19.9 0.0 0.0018 18.0 0.0 2.0 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like AHSP PF09236.10 ETO25487.1 - 0.12 12.9 0.1 2.6 8.5 0.0 2.5 2 0 0 2 2 2 0 Alpha-haemoglobin stabilising protein Corona_M PF01635.18 ETO25487.1 - 1.4 8.2 5.7 2.8 7.2 5.7 1.5 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein AAA PF00004.29 ETO25488.1 - 3.7e-74 247.4 0.0 1.5e-44 151.6 0.0 2.3 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO25488.1 - 3.7e-27 93.9 5.9 1e-13 50.8 1.3 2.6 2 0 0 2 2 2 2 AAA+ lid domain AAA_2 PF07724.14 ETO25488.1 - 3.4e-09 37.1 0.3 0.0088 16.2 0.0 3.6 3 1 0 3 3 3 2 AAA domain (Cdc48 subfamily) AAA_16 PF13191.6 ETO25488.1 - 1.8e-06 28.4 0.1 0.003 18.0 0.0 3.5 2 1 0 3 3 3 1 AAA ATPase domain RuvB_N PF05496.12 ETO25488.1 - 1.6e-05 24.7 0.0 0.00034 20.4 0.0 2.8 2 1 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETO25488.1 - 5.3e-05 23.5 0.1 0.064 13.5 0.0 3.0 2 1 1 3 3 3 1 AAA domain AAA_5 PF07728.14 ETO25488.1 - 5.5e-05 23.2 0.2 0.052 13.6 0.0 3.3 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_14 PF13173.6 ETO25488.1 - 0.00011 22.2 0.0 0.1 12.6 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_25 PF13481.6 ETO25488.1 - 0.001 18.7 0.1 0.15 11.6 0.0 2.7 2 1 0 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ETO25488.1 - 0.0017 18.1 0.2 0.0046 16.7 0.0 1.7 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 ETO25488.1 - 0.0042 17.6 0.1 0.021 15.4 0.0 2.1 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ETO25488.1 - 0.005 17.2 0.0 0.017 15.5 0.0 1.9 2 0 0 2 2 1 1 RNA helicase IstB_IS21 PF01695.17 ETO25488.1 - 0.0085 15.8 0.1 0.021 14.6 0.1 1.6 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO25488.1 - 0.016 14.6 0.0 0.051 13.0 0.0 1.8 2 0 0 2 2 1 0 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ETO25488.1 - 0.016 14.3 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 ETO25488.1 - 0.018 14.9 0.1 0.056 13.4 0.1 1.9 2 1 0 2 2 1 0 NACHT domain TIP49 PF06068.13 ETO25488.1 - 0.019 14.2 0.0 0.05 12.8 0.0 1.7 1 0 0 1 1 1 0 TIP49 P-loop domain AAA_28 PF13521.6 ETO25488.1 - 0.022 15.0 0.0 0.55 10.5 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_33 PF13671.6 ETO25488.1 - 0.026 14.7 0.0 0.06 13.5 0.0 1.6 1 0 0 1 1 1 0 AAA domain Vps4_C PF09336.10 ETO25488.1 - 0.058 13.4 0.6 0.22 11.5 0.1 2.2 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain ATPase PF06745.13 ETO25488.1 - 0.068 12.5 0.0 1.8 7.9 0.0 2.4 2 0 0 2 2 2 0 KaiC ResIII PF04851.15 ETO25488.1 - 0.07 13.1 0.3 1.6 8.7 0.0 2.4 2 0 0 2 2 2 0 Type III restriction enzyme, res subunit Rad17 PF03215.15 ETO25488.1 - 0.079 12.9 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 Rad17 P-loop domain ABC_tran PF00005.27 ETO25488.1 - 0.1 13.1 0.0 0.29 11.6 0.0 1.8 1 0 0 1 1 1 0 ABC transporter CDC48_N PF02359.18 ETO25489.1 - 5.8e-16 58.4 0.1 2.3e-15 56.5 0.1 1.9 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), N-terminal domain AAA PF00004.29 ETO25489.1 - 1e-09 38.9 0.2 2.1e-09 37.9 0.0 1.6 2 0 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) CDC48_2 PF02933.17 ETO25489.1 - 6.2e-07 29.1 0.0 1.6e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Cell division protein 48 (CDC48), domain 2 AAA_16 PF13191.6 ETO25489.1 - 0.0001 22.7 0.0 0.00017 22.0 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 ETO25489.1 - 0.0011 18.8 0.2 0.0023 17.7 0.1 1.5 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ETO25489.1 - 0.0014 18.8 0.1 0.0024 18.0 0.1 1.3 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 ETO25489.1 - 0.0021 17.3 1.0 0.019 14.2 0.0 2.1 2 0 0 2 2 2 1 TIP49 P-loop domain AAA_22 PF13401.6 ETO25489.1 - 0.0037 17.5 0.0 0.0068 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO25489.1 - 0.0044 17.0 0.1 0.0092 16.0 0.1 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETO25489.1 - 0.019 15.5 0.0 0.044 14.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETO25489.1 - 0.02 14.6 0.1 0.036 13.8 0.1 1.3 1 0 0 1 1 1 0 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO25489.1 - 0.02 14.3 0.1 0.035 13.5 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI A-2_8-polyST PF07388.11 ETO25489.1 - 0.025 13.2 0.1 0.037 12.6 0.1 1.2 1 0 0 1 1 1 0 Alpha-2,8-polysialyltransferase (POLYST) AAA_24 PF13479.6 ETO25489.1 - 0.08 12.7 0.1 0.64 9.7 0.0 2.2 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO25489.1 - 0.082 13.3 0.0 0.24 11.8 0.0 1.8 2 0 0 2 2 1 0 RNA helicase AAA_7 PF12775.7 ETO25489.1 - 0.099 12.1 0.0 0.17 11.4 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region TsaE PF02367.17 ETO25489.1 - 0.11 12.5 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ETO25489.1 - 0.12 12.3 0.1 0.23 11.3 0.1 1.4 1 0 0 1 1 1 0 NACHT domain AAA_11 PF13086.6 ETO25489.1 - 0.14 12.0 0.1 0.27 11.0 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO25489.1 - 0.19 11.4 0.1 0.32 10.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain LisH_TPL PF17814.1 ETO25490.1 - 0.13 11.9 0.1 0.34 10.6 0.1 1.7 1 0 0 1 1 1 0 LisH-like dimerisation domain Menin PF05053.13 ETO25491.1 - 0.29 9.5 19.8 0.45 8.8 19.8 1.2 1 0 0 1 1 1 0 Menin DUF4551 PF15087.6 ETO25491.1 - 1.4 7.6 14.4 1.7 7.4 14.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) CAP_GLY PF01302.25 ETO25492.1 - 4.2e-26 90.7 6.0 2e-18 66.2 0.2 3.3 3 0 0 3 3 3 2 CAP-Gly domain DnaJ_CXXCXGXG PF00684.19 ETO25492.1 - 0.06 13.7 4.1 0.06 13.7 2.3 1.9 2 1 0 2 2 2 0 DnaJ central domain Multi_ubiq PF14452.6 ETO25492.1 - 0.074 13.3 0.0 0.18 12.1 0.0 1.7 1 0 0 1 1 1 0 Multiubiquitin DUF2318 PF10080.9 ETO25492.1 - 0.33 11.1 2.3 0.63 10.2 2.3 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2318) Apolipo_F PF15148.6 ETO25493.1 - 0.036 13.6 0.2 0.045 13.2 0.2 1.2 1 0 0 1 1 1 0 Apolipoprotein F LAP1C PF05609.12 ETO25494.1 - 1.1 8.3 19.9 1.4 7.9 19.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) GREB1 PF15782.5 ETO25494.1 - 2.7 5.0 18.1 3 4.8 18.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Nop14 PF04147.12 ETO25495.1 - 0.014 13.6 21.9 0.016 13.4 21.9 1.1 1 0 0 1 1 1 0 Nop14-like family Sigma70_ner PF04546.13 ETO25495.1 - 0.035 14.0 13.4 0.04 13.8 13.4 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Serglycin PF04360.12 ETO25495.1 - 0.035 14.0 5.1 0.046 13.7 5.1 1.3 1 0 0 1 1 1 0 Serglycin RNA_pol_3_Rpc31 PF11705.8 ETO25495.1 - 0.041 14.1 24.1 0.059 13.6 24.1 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TLP-20 PF06088.11 ETO25495.1 - 0.085 12.7 3.7 0.1 12.5 3.7 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) BUD22 PF09073.10 ETO25495.1 - 0.14 11.4 16.1 0.15 11.3 16.1 1.1 1 0 0 1 1 1 0 BUD22 SpoIIIAH PF12685.7 ETO25495.1 - 0.28 11.0 7.4 0.32 10.8 7.4 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein RNA_pol_Rpc4 PF05132.14 ETO25495.1 - 0.29 11.6 3.5 0.31 11.5 3.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 SAPS PF04499.15 ETO25495.1 - 0.39 9.5 4.4 0.34 9.6 4.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein NPR3 PF03666.13 ETO25495.1 - 0.49 9.1 6.3 0.56 8.9 6.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SDA1 PF05285.12 ETO25495.1 - 0.49 9.8 24.0 0.55 9.6 24.0 1.1 1 0 0 1 1 1 0 SDA1 DUF913 PF06025.12 ETO25495.1 - 0.53 9.2 2.6 0.54 9.2 2.6 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Presenilin PF01080.17 ETO25495.1 - 0.54 9.0 2.8 0.57 8.9 2.8 1.0 1 0 0 1 1 1 0 Presenilin Trypan_PARP PF05887.11 ETO25495.1 - 0.86 9.6 14.1 1.1 9.3 14.1 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CDC27 PF09507.10 ETO25495.1 - 1 8.7 11.7 1.2 8.5 11.7 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIA PF03153.13 ETO25495.1 - 1 9.3 22.9 1.1 9.2 22.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit TFIIF_alpha PF05793.12 ETO25495.1 - 3.2 6.2 24.2 3.4 6.1 24.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mpp10 PF04006.12 ETO25495.1 - 3.6 5.9 23.6 4.4 5.6 23.6 1.1 1 0 0 1 1 1 0 Mpp10 protein Pox_Ag35 PF03286.14 ETO25495.1 - 7.2 6.4 18.0 11 5.8 18.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Vfa1 PF08432.10 ETO25495.1 - 8 6.8 10.3 11 6.4 10.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Mannosyl_trans3 PF11051.8 ETO25496.1 - 1.3e-06 28.0 0.3 1.6e-06 27.7 0.3 1.1 1 0 0 1 1 1 1 Mannosyltransferase putative SR-25 PF10500.9 ETO25496.1 - 7.5 6.1 12.3 9.3 5.8 12.3 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4378 PF14309.6 ETO25497.1 - 0.00098 19.5 1.8 0.0016 18.8 1.2 1.7 1 1 1 2 2 2 1 Domain of unknown function (DUF4378) NDUF_C2 PF06374.11 ETO25498.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase subunit b14.5b (NDUFC2) S6PP PF05116.13 ETO25499.1 - 0.052 13.1 0.0 0.086 12.3 0.0 1.3 1 0 0 1 1 1 0 Sucrose-6F-phosphate phosphohydrolase PI3_PI4_kinase PF00454.27 ETO25501.1 - 1.5e-40 139.6 0.3 3.3e-39 135.2 0.3 2.2 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3Ka PF00613.20 ETO25501.1 - 1.1e-37 129.2 4.6 1.6e-37 128.7 4.2 1.5 1 1 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) TLD PF07534.16 ETO25502.1 - 3.9e-23 82.2 2.7 3.9e-23 82.2 2.7 2.3 2 2 0 2 2 2 1 TLD Gcw_chp PF09694.10 ETO25502.1 - 0.0085 16.1 0.1 0.42 10.6 0.0 2.2 1 1 1 2 2 2 1 Bacterial protein of unknown function (Gcw_chp) Gti1_Pac2 PF09729.9 ETO25502.1 - 0.42 10.7 9.0 1.3 9.1 6.2 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Menin PF05053.13 ETO25502.1 - 1.8 6.8 20.7 2.7 6.3 13.9 2.1 2 0 0 2 2 2 0 Menin Presenilin PF01080.17 ETO25502.1 - 6.1 5.5 9.7 2.4 6.8 6.3 1.7 2 0 0 2 2 2 0 Presenilin NST1 PF13945.6 ETO25502.1 - 9.9 6.2 30.2 3.6 7.7 1.7 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF4543 PF15076.6 ETO25504.1 - 0.11 12.6 0.4 0.24 11.6 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4543) ETRAMP PF09716.10 ETO25504.1 - 8.9 6.5 13.2 0.072 13.2 5.0 1.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Flt3_lig PF02947.14 ETO25505.1 - 0.076 13.2 0.9 0.2 11.8 0.2 1.9 2 0 0 2 2 2 0 flt3 ligand DARPP-32 PF05395.12 ETO25506.1 - 0.098 12.9 3.3 0.12 12.6 3.3 1.0 1 0 0 1 1 1 0 Protein phosphatase inhibitor 1/DARPP-32 DUF3298 PF11738.8 ETO25506.1 - 0.29 12.2 1.7 0.8 10.8 1.7 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3298) DUF4407 PF14362.6 ETO25506.1 - 1.5 8.1 8.0 1.8 7.8 8.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Sec62 PF03839.16 ETO25506.1 - 9 5.7 8.6 16 4.9 8.6 1.4 1 1 0 1 1 1 0 Translocation protein Sec62 PDZ PF00595.24 ETO25508.1 - 0.0038 17.6 0.7 0.018 15.4 0.0 2.3 3 0 0 3 3 3 1 PDZ domain PDZ_2 PF13180.6 ETO25508.1 - 0.015 15.6 0.0 0.033 14.5 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ_6 PF17820.1 ETO25508.1 - 0.044 13.6 0.0 0.091 12.6 0.0 1.5 1 0 0 1 1 1 0 PDZ domain K_channel_TID PF07941.11 ETO25508.1 - 0.091 13.2 1.0 0.18 12.3 1.0 1.4 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain PTS_IIA PF02255.16 ETO25509.1 - 0.035 14.2 0.2 0.076 13.1 0.2 1.5 1 0 0 1 1 1 0 PTS system, Lactose/Cellobiose specific IIA subunit Exo_endo_phos_2 PF14529.6 ETO25510.1 - 0.0042 16.9 1.5 0.02 14.7 0.3 2.5 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase RNA_pol_Rbc25 PF08292.12 ETO25510.1 - 1.1 9.5 4.7 7.9 6.7 0.1 2.8 2 0 0 2 2 2 0 RNA polymerase III subunit Rpc25 PigN PF04987.14 ETO25514.1 - 0.3 9.9 8.3 0.46 9.3 7.8 1.6 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Serinc PF03348.15 ETO25514.1 - 1.4 7.7 4.9 2.3 7.0 4.9 1.2 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF676 PF05057.14 ETO25518.1 - 9.8e-29 100.4 0.6 8.6e-27 94.1 0.6 3.0 1 1 0 1 1 1 1 Putative serine esterase (DUF676) PGAP1 PF07819.13 ETO25518.1 - 0.017 14.9 0.1 0.038 13.7 0.1 1.7 1 1 0 1 1 1 0 PGAP1-like protein Abhydrolase_1 PF00561.20 ETO25518.1 - 0.035 13.8 0.3 3.2 7.3 0.0 2.7 2 1 1 3 3 3 0 alpha/beta hydrolase fold CDC45 PF02724.14 ETO25518.1 - 0.077 11.3 33.1 0.18 10.0 33.1 1.6 1 0 0 1 1 1 0 CDC45-like protein Abhydrolase_6 PF12697.7 ETO25518.1 - 0.16 12.6 0.0 0.36 11.4 0.0 1.6 1 1 0 1 1 1 0 Alpha/beta hydrolase family PI3K_1B_p101 PF10486.9 ETO25518.1 - 1.2 6.8 17.0 2 6.1 17.0 1.3 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RGS-like PF09128.11 ETO25518.1 - 5.5 6.7 14.5 7.1 6.3 12.1 2.2 2 0 0 2 2 2 0 Regulator of G protein signalling-like domain TMEM234 PF10639.9 ETO25519.1 - 0.047 13.7 0.5 0.13 12.3 0.3 1.8 1 1 0 1 1 1 0 Putative transmembrane family 234 CRCB PF02537.15 ETO25521.1 - 5.7 7.3 15.1 0.15 12.4 5.0 2.8 3 1 0 3 3 3 0 CrcB-like protein, Camphor Resistance (CrcB) EF-hand_8 PF13833.6 ETO25522.1 - 4.1e-07 29.8 1.0 6.9e-05 22.6 0.0 3.2 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_7 PF13499.6 ETO25522.1 - 9.3e-07 29.2 0.1 1.8e-06 28.3 0.1 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO25522.1 - 1.7e-06 27.1 0.3 0.032 13.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO25522.1 - 7.2e-05 22.4 0.2 0.46 10.5 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_4 PF12763.7 ETO25522.1 - 0.028 14.4 0.1 2.3 8.2 0.1 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_5 PF13202.6 ETO25522.1 - 0.028 13.9 0.7 2.8 7.6 0.1 2.7 2 0 0 2 2 2 0 EF hand RRM_1 PF00076.22 ETO25524.1 - 6e-09 35.6 0.0 0.00058 19.6 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) NUDIX PF00293.28 ETO25525.1 - 1.6e-06 28.2 0.0 3.8e-06 27.0 0.0 1.6 1 1 0 1 1 1 1 NUDIX domain 7TM_GPCR_Sri PF10327.9 ETO25526.1 - 0.0018 17.5 0.4 0.0018 17.5 0.4 1.4 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Sri DUF4162 PF13732.6 ETO25526.1 - 0.0019 18.9 0.6 0.0047 17.6 0.6 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4162) ABC2_membrane_3 PF12698.7 ETO25527.1 - 2.6e-22 79.4 28.5 2.6e-22 79.4 28.5 2.1 2 0 0 2 2 2 1 ABC-2 family transporter protein ABC_tran PF00005.27 ETO25527.1 - 1.8e-20 73.9 0.0 3.1e-20 73.1 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_tran PF00005.27 ETO25528.1 - 6.1e-19 68.9 0.7 5.8e-18 65.7 0.1 2.5 2 1 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ETO25528.1 - 1.4e-09 38.2 0.1 5.4e-07 29.7 0.0 2.2 1 1 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO25528.1 - 0.0065 15.9 0.0 0.25 10.8 0.0 2.3 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain SRP54 PF00448.22 ETO25528.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_23 PF13476.6 ETO25528.1 - 0.084 13.4 0.2 0.084 13.4 0.2 1.8 2 0 0 2 2 2 0 AAA domain SbcCD_C PF13558.6 ETO25528.1 - 0.084 13.1 0.0 0.44 10.8 0.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RCC1_2 PF13540.6 ETO25528.1 - 0.15 11.9 0.0 0.4 10.5 0.0 1.7 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat AAA_29 PF13555.6 ETO25528.1 - 0.17 11.7 0.1 0.44 10.3 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 ETO25529.1 - 1.3e-09 37.6 0.2 1.7e-09 37.3 0.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein PDR_CDR PF06422.12 ETO25529.1 - 0.045 13.6 1.8 0.26 11.2 0.2 2.4 2 0 0 2 2 2 0 CDR ABC transporter BNR_6 PF15899.5 ETO25529.1 - 0.17 12.0 4.7 0.2 11.8 0.1 3.5 3 0 0 3 3 3 0 BNR-Asp box repeat BNR PF02012.20 ETO25529.1 - 1.5 9.1 4.7 0.7 10.1 0.6 2.6 2 0 0 2 2 2 0 BNR/Asp-box repeat Ax_dynein_light PF10211.9 ETO25530.1 - 3e-24 86.0 10.6 3e-24 86.0 10.6 2.2 1 1 1 2 2 2 1 Axonemal dynein light chain DUF1985 PF09331.11 ETO25530.1 - 0.026 14.5 2.8 0.079 13.0 2.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF1985) Ribosomal_L36e PF01158.18 ETO25530.1 - 0.041 14.1 0.3 0.041 14.1 0.3 2.5 3 1 0 3 3 3 0 Ribosomal protein L36e Sulfotransfer_3 PF13469.6 ETO25530.1 - 0.049 14.0 0.7 0.13 12.7 0.1 1.8 2 0 0 2 2 2 0 Sulfotransferase family Med15 PF09606.10 ETO25531.1 - 0.0047 15.7 66.7 0.0067 15.2 66.7 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal Arm PF00514.23 ETO25531.1 - 0.27 11.3 6.5 5.8 7.1 0.7 2.8 2 0 0 2 2 2 0 Armadillo/beta-catenin-like repeat PK PF00224.21 ETO25532.1 - 0.0022 16.9 0.5 0.0022 16.9 0.5 1.6 2 0 0 2 2 2 1 Pyruvate kinase, barrel domain Exonuc_VII_L PF02601.15 ETO25533.1 - 3.1 7.3 9.6 5 6.6 9.6 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit SelK_SelG PF10961.8 ETO25534.1 - 4.1 8.1 15.2 15 6.3 15.3 2.0 1 1 0 1 1 1 0 Selenoprotein SelK_SelG BRCT_2 PF16589.5 ETO25536.1 - 4e-08 33.6 0.0 0.00029 21.2 0.0 2.9 2 0 0 2 2 2 2 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ETO25536.1 - 0.00022 21.0 0.3 0.0027 17.6 0.0 3.0 3 0 0 3 3 3 1 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 ETO25536.1 - 0.0028 17.7 1.3 0.57 10.3 0.0 2.9 3 0 0 3 3 3 2 BRCA1 C Terminus (BRCT) domain ALMT PF11744.8 ETO25536.1 - 1.5 7.6 9.0 2.3 6.9 9.0 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter PA26 PF04636.13 ETO25536.1 - 3 6.6 10.9 5.4 5.8 10.9 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Hydrolase PF00702.26 ETO25539.1 - 6.9e-12 46.1 0.2 1.8e-05 25.1 0.3 3.2 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO25539.1 - 0.00033 20.7 0.2 0.0019 18.2 0.0 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) E1-E2_ATPase PF00122.20 ETO25539.1 - 0.012 15.1 0.1 0.023 14.2 0.1 1.4 1 0 0 1 1 1 0 E1-E2 ATPase Methyltransf_12 PF08242.12 ETO25539.1 - 0.2 12.4 4.5 4.7 8.0 0.1 3.3 3 0 0 3 3 3 0 Methyltransferase domain Hydrolase_3 PF08282.12 ETO25539.1 - 0.23 11.2 0.0 0.23 11.2 0.0 3.9 4 0 0 4 4 4 0 haloacid dehalogenase-like hydrolase CENP-B_dimeris PF09026.10 ETO25539.1 - 2.7 8.5 11.3 2.3 8.6 0.5 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain RPA43_OB PF17875.1 ETO25539.1 - 3.1 8.4 7.3 99 3.6 0.0 3.4 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I DUF3391 PF11871.8 ETO25539.1 - 3.4 8.2 6.2 0.3 11.6 0.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3391) Hydrolase PF00702.26 ETO25540.1 - 4e-33 115.5 3.3 5.5e-33 115.0 3.3 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ETO25540.1 - 5.7e-24 84.6 0.1 1.2e-23 83.6 0.1 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase_3 PF08282.12 ETO25540.1 - 0.00027 20.8 3.6 0.00036 20.4 1.8 1.9 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ETO25541.1 - 0.017 14.7 0.2 0.017 14.7 0.2 2.4 2 1 2 4 4 4 0 E1-E2 ATPase DUF3754 PF12576.8 ETO25541.1 - 0.1 12.6 2.5 0.35 10.8 2.4 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF3754) DUF996 PF06195.13 ETO25541.1 - 0.18 12.1 2.1 0.6 10.4 1.4 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF996) Ac76 PF05814.11 ETO25544.1 - 0.1 12.6 1.2 0.21 11.6 1.2 1.5 1 0 0 1 1 1 0 Orf76 (Ac76) PI3_PI4_kinase PF00454.27 ETO25545.1 - 4.1e-22 79.2 0.2 5.4e-22 78.8 0.2 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 ETO25545.1 - 0.077 12.3 0.0 0.1 11.9 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) GlcNAc PF11397.8 ETO25546.1 - 4.9e-13 49.3 0.0 9.5e-13 48.3 0.0 1.4 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) DUF1170 PF06663.13 ETO25546.1 - 0.054 13.2 0.2 0.089 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1170) GlcNAc PF11397.8 ETO25547.1 - 1.7e-62 211.9 0.9 2.2e-62 211.5 0.9 1.1 1 0 0 1 1 1 1 Glycosyltransferase (GlcNAc) NUC PF18510.1 ETO25549.1 - 0.24 11.9 4.1 0.26 11.7 4.1 1.0 1 0 0 1 1 1 0 Nuclease domain Pyr_redox_2 PF07992.14 ETO25550.1 - 7.9e-39 133.6 0.0 1e-38 133.2 0.0 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETO25550.1 - 4.4e-17 62.3 0.0 7.5e-17 61.6 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ETO25550.1 - 1.2e-15 57.8 0.0 2.4e-15 56.9 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO25550.1 - 1e-09 38.1 0.0 2e-09 37.1 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase RasGEF PF00617.19 ETO25551.1 - 3.9e-05 23.9 0.0 7e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 RasGEF domain YL1 PF05764.13 ETO25553.1 - 1.8e-06 28.3 5.5 1.8e-06 28.3 5.5 1.2 1 0 0 1 1 1 1 YL1 nuclear protein eIF3_subunit PF08597.10 ETO25553.1 - 0.0035 17.3 14.2 0.0051 16.8 14.2 1.2 1 0 0 1 1 1 1 Translation initiation factor eIF3 subunit G0-G1_switch_2 PF15103.6 ETO25553.1 - 0.0055 17.1 2.5 0.0096 16.3 2.5 1.5 1 0 0 1 1 1 1 G0/G1 switch protein 2 TLP-20 PF06088.11 ETO25553.1 - 0.0094 15.9 2.1 0.013 15.4 2.1 1.3 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Smg4_UPF3 PF03467.15 ETO25553.1 - 0.017 15.2 8.7 0.024 14.6 8.7 1.2 1 0 0 1 1 1 0 Smg-4/UPF3 family Rrn6 PF10214.9 ETO25553.1 - 0.021 13.4 4.2 0.021 13.3 4.2 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor AP3D1 PF06375.11 ETO25553.1 - 0.022 15.0 12.6 0.034 14.4 12.6 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 Coilin_N PF15862.5 ETO25553.1 - 0.026 14.3 7.3 0.035 13.9 7.3 1.3 1 0 0 1 1 1 0 Coilin N-terminus Myc_N PF01056.18 ETO25553.1 - 0.037 13.9 5.6 0.038 13.9 5.6 1.2 1 0 0 1 1 1 0 Myc amino-terminal region FAM176 PF14851.6 ETO25553.1 - 0.05 13.3 7.6 0.082 12.6 7.6 1.5 1 0 0 1 1 1 0 FAM176 family Cnd2 PF05786.14 ETO25553.1 - 0.056 12.1 14.8 0.088 11.5 14.8 1.2 1 0 0 1 1 1 0 Condensin complex subunit 2 TFIIF_alpha PF05793.12 ETO25553.1 - 0.057 12.0 18.7 0.086 11.4 18.7 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNA_polI_A34 PF08208.11 ETO25553.1 - 0.061 13.4 17.2 0.077 13.1 17.2 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RR_TM4-6 PF06459.12 ETO25553.1 - 0.12 12.2 10.1 0.18 11.6 10.1 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DDHD PF02862.17 ETO25553.1 - 0.15 12.2 2.0 0.15 12.2 2.0 1.2 1 0 0 1 1 1 0 DDHD domain TRAP_alpha PF03896.16 ETO25553.1 - 0.15 11.2 6.1 0.19 10.9 6.1 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Presenilin PF01080.17 ETO25553.1 - 0.17 10.7 3.1 0.15 10.8 3.1 1.2 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO25553.1 - 0.19 10.7 2.2 0.2 10.6 2.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) GEN1_C PF18380.1 ETO25553.1 - 0.29 12.1 10.1 0.48 11.3 10.1 1.4 1 0 0 1 1 1 0 Holliday junction resolvase Gen1 C-terminal domain RPN2_C PF18004.1 ETO25553.1 - 0.41 10.6 14.9 0.62 10.0 14.9 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DUF2052 PF09747.9 ETO25553.1 - 0.45 10.6 19.5 0.68 10.0 19.6 1.4 1 1 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) CPSF100_C PF13299.6 ETO25553.1 - 0.52 10.5 10.8 0.74 10.0 10.8 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 ETO25553.1 - 0.54 9.4 6.6 0.64 9.2 6.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO25553.1 - 0.58 8.4 13.2 0.84 7.9 13.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Paf1 PF03985.13 ETO25553.1 - 0.83 8.6 17.3 1.1 8.1 17.3 1.2 1 0 0 1 1 1 0 Paf1 Radial_spoke PF04712.12 ETO25553.1 - 0.91 8.4 13.6 1.4 7.8 13.6 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein DUF4710 PF15828.5 ETO25553.1 - 1 9.5 14.8 2.1 8.5 14.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) DUF4746 PF15928.5 ETO25553.1 - 1.1 8.6 15.7 1.6 8.1 15.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF3381 PF11861.8 ETO25553.1 - 1.1 9.0 20.7 0.15 11.9 16.8 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Peptidase_S49_N PF08496.10 ETO25553.1 - 1.2 9.2 10.4 10 6.1 10.2 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal U3_snoRNA_assoc PF08297.11 ETO25553.1 - 1.2 9.8 14.4 1.9 9.3 14.4 1.3 1 0 0 1 1 1 0 U3 snoRNA associated YqfQ PF14181.6 ETO25553.1 - 1.5 9.0 13.7 2.1 8.5 13.7 1.2 1 0 0 1 1 1 0 YqfQ-like protein Merozoite_SPAM PF07133.11 ETO25553.1 - 1.5 8.7 27.5 2.9 7.8 27.5 1.4 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CobT PF06213.12 ETO25553.1 - 1.6 8.1 14.1 2.6 7.4 14.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RNA_pol_Rpc4 PF05132.14 ETO25553.1 - 1.9 8.9 8.6 2.5 8.5 8.6 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 PBP1_TM PF14812.6 ETO25553.1 - 2.6 8.5 16.1 0.23 11.8 10.4 2.1 3 0 0 3 3 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal MCU PF04678.13 ETO25553.1 - 2.7 8.0 8.9 2.5 8.1 8.3 1.3 1 1 0 1 1 1 0 Mitochondrial calcium uniporter EIIBC-GUT_N PF03612.14 ETO25553.1 - 3.3 7.4 8.5 4.8 6.9 8.5 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus CLN3 PF02487.17 ETO25553.1 - 5.4 5.9 5.8 6.1 5.8 3.0 1.9 2 0 0 2 2 2 0 CLN3 protein DNA_pol_phi PF04931.13 ETO25553.1 - 8.6 4.3 17.4 13 3.7 17.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi HSP90 PF00183.18 ETO25553.1 - 9 5.1 19.6 12 4.6 19.6 1.1 1 0 0 1 1 1 0 Hsp90 protein DIM1 PF02966.16 ETO25554.1 - 0.013 15.2 0.2 0.027 14.2 0.2 1.5 1 0 0 1 1 1 0 Mitosis protein DIM1 TTL PF03133.15 ETO25555.1 - 4e-28 98.4 0.2 2.8e-16 59.5 0.1 2.8 2 1 0 2 2 2 2 Tubulin-tyrosine ligase family Y_Y_Y PF07495.13 ETO25555.1 - 0.049 13.6 1.3 0.23 11.4 0.1 2.3 2 0 0 2 2 2 0 Y_Y_Y domain TMEM107 PF14995.6 ETO25556.1 - 0.08 13.4 1.5 0.18 12.3 1.5 1.5 1 0 0 1 1 1 0 Transmembrane protein PA26 PF04636.13 ETO25557.1 - 0.097 11.6 1.6 0.085 11.8 0.1 1.6 1 1 1 2 2 2 0 PA26 p53-induced protein (sestrin) LMBR1 PF04791.16 ETO25557.1 - 3.1 6.6 4.6 3.7 6.4 4.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein CCDC106 PF15794.5 ETO25558.1 - 0.055 13.2 7.3 0.064 13.0 7.3 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Med19 PF10278.9 ETO25558.1 - 0.084 12.8 6.2 0.1 12.5 6.2 1.1 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Menin PF05053.13 ETO25558.1 - 0.12 10.7 14.1 0.13 10.7 14.1 1.0 1 0 0 1 1 1 0 Menin Sec62 PF03839.16 ETO25558.1 - 5.7 6.4 8.6 6.7 6.1 8.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 ALMT PF11744.8 ETO25558.1 - 5.9 5.6 9.8 5.9 5.6 9.8 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter MDFI PF15316.6 ETO25558.1 - 9 6.3 9.9 11 6.0 9.9 1.2 1 0 0 1 1 1 0 MyoD family inhibitor TRM13 PF05206.14 ETO25560.1 - 0.025 14.1 5.6 0.13 11.8 5.9 1.9 1 1 1 2 2 2 0 Methyltransferase TRM13 Methyltransf_32 PF13679.6 ETO25560.1 - 0.039 14.0 6.2 0.069 13.1 6.2 1.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_31 PF13847.6 ETO25560.1 - 0.099 12.4 2.9 0.21 11.4 2.9 1.6 1 1 1 2 2 2 0 Methyltransferase domain NPCC PF08058.11 ETO25561.1 - 0.6 10.2 2.6 1.8 8.6 0.3 2.0 2 0 0 2 2 2 0 Nuclear pore complex component Glyco_tranf_2_4 PF13704.6 ETO25562.1 - 8.4e-08 32.6 1.2 2e-07 31.4 1.2 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 CdiI_2 PF18593.1 ETO25563.1 - 0.18 12.5 1.0 0.23 12.2 1.0 1.2 1 0 0 1 1 1 0 CdiI immunity protein UCH PF00443.29 ETO25564.1 - 1.6e-45 155.6 6.6 1.6e-45 155.6 6.6 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO25564.1 - 2e-19 70.4 12.1 2e-19 70.4 12.1 2.1 3 1 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase NNMT_PNMT_TEMT PF01234.17 ETO25564.1 - 0.003 16.8 0.0 0.0092 15.2 0.0 1.8 1 0 0 1 1 1 1 NNMT/PNMT/TEMT family USP7_ICP0_bdg PF12436.8 ETO25564.1 - 0.0037 16.6 1.3 0.0062 15.9 0.0 1.9 2 0 0 2 2 2 1 ICP0-binding domain of Ubiquitin-specific protease 7 Connexin PF00029.19 ETO25564.1 - 0.047 13.4 2.4 0.12 12.1 2.4 1.6 1 0 0 1 1 1 0 Connexin RPA43_OB PF17875.1 ETO25564.1 - 0.068 13.8 6.1 3.6 8.2 0.9 3.2 4 0 0 4 4 4 0 RPA43 OB domain in RNA Pol I SARA PF11409.8 ETO25564.1 - 0.1 12.8 0.1 0.25 11.6 0.1 1.6 1 0 0 1 1 1 0 Smad anchor for receptor activation (SARA) OAD_gamma PF04277.13 ETO25564.1 - 0.24 12.0 0.9 0.49 11.0 0.9 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain HA2 PF04408.23 ETO25564.1 - 1.2 9.5 3.4 3.5 8.0 3.4 1.7 1 0 0 1 1 1 0 Helicase associated domain (HA2) FAM176 PF14851.6 ETO25564.1 - 2.4 7.8 5.9 0.3 10.7 0.8 2.1 2 0 0 2 2 2 0 FAM176 family UPF0122 PF04297.14 ETO25565.1 - 0.0072 16.5 0.4 0.048 13.9 0.1 2.1 2 0 0 2 2 2 1 Putative helix-turn-helix protein, YlxM / p13 like RNA_pol PF00940.19 ETO25565.1 - 0.015 14.2 0.1 0.017 14.0 0.1 1.0 1 0 0 1 1 1 0 DNA-dependent RNA polymerase DUF1192 PF06698.11 ETO25566.1 - 0.011 15.8 0.1 0.011 15.8 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1192) Presenilin PF01080.17 ETO25568.1 - 2.6 6.7 11.2 11 4.6 7.2 2.1 2 0 0 2 2 2 0 Presenilin Mpp10 PF04006.12 ETO25571.1 - 9.3e-34 116.9 45.5 7e-25 87.5 7.9 2.0 2 0 0 2 2 2 2 Mpp10 protein FAM60A PF15396.6 ETO25571.1 - 5 7.1 21.9 0.69 9.9 0.2 2.4 2 1 0 2 2 2 0 Protein Family FAM60A FGF-BP1 PF06473.12 ETO25572.1 - 0.004 17.0 9.0 0.0067 16.3 9.0 1.3 1 0 0 1 1 1 1 FGF binding protein 1 (FGF-BP1) BUD22 PF09073.10 ETO25572.1 - 0.016 14.6 29.2 0.021 14.2 29.2 1.3 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO25572.1 - 0.024 13.4 10.9 0.031 13.1 10.9 1.1 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 ETO25572.1 - 0.28 9.6 61.6 6.3 5.1 61.6 2.0 1 1 0 1 1 1 0 Mpp10 protein TFIIF_alpha PF05793.12 ETO25572.1 - 2 6.9 44.4 3.1 6.3 44.4 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mob1_phocein PF03637.17 ETO25573.1 - 7.7e-63 211.5 0.2 1.1e-62 211.0 0.2 1.2 1 0 0 1 1 1 1 Mob1/phocein family UCH PF00443.29 ETO25574.1 - 1.1e-12 48.1 0.5 2.3e-12 47.0 0.0 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO25574.1 - 0.00081 19.1 0.1 0.0025 17.4 0.0 1.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase MRI PF15325.6 ETO25574.1 - 0.0064 17.6 0.6 0.044 14.9 0.0 2.5 3 0 0 3 3 3 1 Modulator of retrovirus infection WD40 PF00400.32 ETO25575.1 - 2.1e-124 401.8 50.0 6.4e-10 39.5 0.3 16.6 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25575.1 - 2.1e-26 92.1 18.1 0.21 11.9 0.0 13.3 3 3 11 14 14 14 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25575.1 - 3.9e-20 72.1 14.8 0.3 10.0 0.1 12.5 4 3 9 13 13 13 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO25575.1 - 7.2e-09 35.8 0.0 1.9e-08 34.4 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO25575.1 - 0.00012 22.7 0.3 0.0006 20.4 0.0 2.5 2 0 0 2 2 1 1 AAA domain Pentapeptide PF00805.22 ETO25575.1 - 0.0002 21.0 3.0 0.00044 19.8 3.0 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO25575.1 - 0.00081 19.5 0.5 20 5.4 0.0 6.1 4 1 1 5 5 5 0 Strictosidine synthase AAA_14 PF13173.6 ETO25575.1 - 0.00098 19.2 0.3 0.006 16.6 0.3 2.5 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO25575.1 - 0.0012 19.1 0.0 0.0047 17.2 0.0 2.0 1 0 0 1 1 1 1 AAA domain Pentapeptide_4 PF13599.6 ETO25575.1 - 0.026 14.7 0.2 0.099 12.8 0.2 2.0 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA_30 PF13604.6 ETO25575.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma70_r1_1 PF03979.14 ETO25575.1 - 0.33 11.0 6.4 2.3 8.3 6.4 2.5 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 FixH PF05751.11 ETO25578.1 - 0.076 13.0 1.9 0.19 11.7 0.1 2.1 2 1 0 2 2 2 0 FixH DUF2448 PF10476.9 ETO25578.1 - 0.086 12.7 2.0 0.39 10.5 0.3 2.0 2 0 0 2 2 2 0 Protein of unknown function C-terminus (DUF2448) PDR_CDR PF06422.12 ETO25578.1 - 0.12 12.3 2.2 0.28 11.1 0.3 2.4 2 1 0 2 2 2 0 CDR ABC transporter Presenilin PF01080.17 ETO25578.1 - 0.34 9.6 11.4 0.46 9.2 11.4 1.2 1 0 0 1 1 1 0 Presenilin DUF4446 PF14584.6 ETO25578.1 - 0.46 10.5 8.7 0.056 13.4 1.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) SLC12 PF03522.15 ETO25578.1 - 1.1 8.2 18.5 1.6 7.6 18.5 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Serinc PF03348.15 ETO25578.1 - 2.1 7.2 12.5 1.9 7.3 1.4 1.8 1 1 1 2 2 2 0 Serine incorporator (Serinc) HCO3_cotransp PF00955.21 ETO25578.1 - 4.4 6.0 10.5 0.51 9.1 3.7 2.0 2 0 0 2 2 2 0 HCO3- transporter family Ctr PF04145.15 ETO25578.1 - 5.5 7.6 13.6 0.13 12.8 2.1 2.1 1 1 1 2 2 2 0 Ctr copper transporter family DUF4834 PF16118.5 ETO25578.1 - 9.8 7.2 21.1 0.11 13.4 4.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) CAP_GLY PF01302.25 ETO25579.1 - 5.7e-16 58.3 1.7 9.9e-16 57.5 1.7 1.3 1 0 0 1 1 1 1 CAP-Gly domain FSA_C PF10479.9 ETO25579.1 - 0.05 11.7 8.7 0.066 11.3 8.7 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF2012 PF09430.10 ETO25580.1 - 8.7e-06 25.9 0.3 0.00053 20.1 0.2 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF2012) DUF4149 PF13664.6 ETO25580.1 - 0.04 14.2 0.3 0.08 13.3 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4149) DUF3783 PF12646.7 ETO25581.1 - 0.066 13.2 0.2 8.5 6.4 0.1 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF3783) RNA_polI_A14 PF08203.11 ETO25581.1 - 1.2 9.9 3.2 14 6.5 0.4 2.3 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 WD40 PF00400.32 ETO25582.1 - 1.2e-06 29.1 5.9 0.14 13.1 0.1 5.5 5 1 0 5 5 5 2 WD domain, G-beta repeat CorA PF01544.18 ETO25583.1 - 2.4e-27 96.0 0.0 3.6e-27 95.4 0.0 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein NUDIX PF00293.28 ETO25584.1 - 4.8e-14 52.5 0.0 7.7e-14 51.9 0.0 1.3 1 0 0 1 1 1 1 NUDIX domain Nudix_N_2 PF14803.6 ETO25584.1 - 2.7e-07 30.4 0.3 1.2e-06 28.4 0.0 2.2 2 0 0 2 2 2 1 Nudix N-terminal Spidroin_N PF16763.5 ETO25587.1 - 0.05 13.6 1.0 0.075 13.1 0.2 1.7 2 0 0 2 2 2 0 Major ampullate spidroin 1, spider silk protein 1, N-term CRA PF06589.11 ETO25587.1 - 0.57 10.3 3.5 0.67 10.1 0.2 2.4 2 1 0 2 2 2 0 Circumsporozoite-related antigen (CRA) DUF5358 PF17311.2 ETO25588.1 - 0.0086 16.1 3.4 0.026 14.5 3.4 1.8 1 0 0 1 1 1 1 Family of unknown function (DUF5358) MIT PF04212.18 ETO25588.1 - 0.065 13.3 0.0 0.27 11.3 0.0 2.1 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain Neugrin PF06413.11 ETO25588.1 - 0.21 11.6 6.5 0.53 10.3 6.5 1.6 1 0 0 1 1 1 0 Neugrin CENP-B_dimeris PF09026.10 ETO25588.1 - 0.3 11.5 2.1 10 6.6 1.1 3.3 3 0 0 3 3 3 0 Centromere protein B dimerisation domain SAM_2 PF07647.17 ETO25589.1 - 0.032 14.4 0.0 0.054 13.6 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ras PF00071.22 ETO25590.1 - 1.5e-12 47.4 0.2 4e-06 26.5 0.0 2.3 2 1 0 2 2 2 2 Ras family HEAT PF02985.22 ETO25591.1 - 0.0002 21.4 2.8 0.31 11.4 0.0 4.1 4 0 0 4 4 4 2 HEAT repeat TIP120 PF08623.10 ETO25591.1 - 0.036 13.8 1.3 0.044 13.5 0.4 1.7 2 0 0 2 2 2 0 TATA-binding protein interacting (TIP20) Tti2 PF10521.9 ETO25591.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Tti2 family Autoind_bind PF03472.15 ETO25591.1 - 0.15 11.6 0.0 0.21 11.1 0.0 1.2 1 0 0 1 1 1 0 Autoinducer binding domain EF_TS PF00889.19 ETO25593.1 - 8.1e-39 133.4 0.4 8.1e-39 133.4 0.4 1.6 2 0 0 2 2 2 1 Elongation factor TS DUF1120 PF06551.12 ETO25593.1 - 0.052 13.7 0.2 0.15 12.2 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1120) VPS13_C PF16909.5 ETO25595.1 - 9.6e-05 22.2 0.1 0.00098 18.9 0.0 2.5 2 2 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 ETO25595.1 - 0.0041 16.5 0.1 0.012 15.0 0.0 1.6 1 1 0 1 1 1 1 SHR-binding domain of vacuolar-sorting associated protein 13 RGS12_us1 PF16613.5 ETO25595.1 - 0.12 12.7 1.1 0.22 11.8 1.1 1.4 1 0 0 1 1 1 0 Unstructured region of RGS12 Kelch_1 PF01344.25 ETO25597.1 - 2.2e-05 23.9 2.3 0.18 11.4 0.2 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO25597.1 - 5.6e-05 23.3 11.0 0.09 13.1 0.4 5.0 6 0 0 6 6 6 3 Kelch motif Kelch_5 PF13854.6 ETO25597.1 - 0.0017 18.3 5.4 0.0029 17.6 0.8 3.6 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO25597.1 - 0.032 14.5 0.0 0.19 12.0 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO25597.1 - 0.046 13.7 1.2 0.88 9.6 0.2 3.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO25597.1 - 0.056 13.4 10.5 0.4 10.7 1.0 5.3 6 1 0 6 6 6 0 Kelch motif N_Asn_amidohyd PF14736.6 ETO25597.1 - 0.073 12.2 0.1 10 5.2 0.0 2.3 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase UL11 PF11094.8 ETO25597.1 - 0.14 12.1 0.0 0.82 9.6 0.0 2.2 2 0 0 2 2 2 0 Membrane-associated tegument protein DUF4228 PF14009.6 ETO25598.1 - 0.046 14.1 0.1 0.07 13.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4228) Zip PF02535.22 ETO25598.1 - 0.14 11.3 0.5 0.15 11.2 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO25598.1 - 0.37 9.5 4.4 0.53 9.0 4.4 1.2 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 ETO25598.1 - 0.65 10.6 16.8 1.4 9.5 16.8 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Apc15p PF05841.11 ETO25598.1 - 0.72 10.7 12.6 1.6 9.6 12.6 1.5 1 0 0 1 1 1 0 Apc15p protein Menin PF05053.13 ETO25598.1 - 1.4 7.2 9.9 1.8 6.8 9.9 1.2 1 0 0 1 1 1 0 Menin Gti1_Pac2 PF09729.9 ETO25598.1 - 2.5 8.2 11.0 4.7 7.3 11.0 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family Glycos_transf_1 PF00534.20 ETO25600.1 - 5.7e-24 84.6 0.0 9.5e-24 83.9 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO25600.1 - 9.9e-20 71.3 0.0 1.4e-19 70.9 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferases group 1 HU-HIG PF18291.1 ETO25600.1 - 0.051 13.7 0.0 0.4 10.8 0.1 2.1 2 0 0 2 2 2 0 HU domain fused to wHTH, Ig, or Glycine-rich motif Serglycin PF04360.12 ETO25601.1 - 0.071 13.1 0.4 0.1 12.5 0.4 1.4 1 0 0 1 1 1 0 Serglycin FCD PF07729.12 ETO25601.1 - 0.094 13.1 0.0 0.16 12.4 0.0 1.3 1 0 0 1 1 1 0 FCD domain Pox_A12 PF04651.13 ETO25602.1 - 0.019 15.1 1.9 0.24 11.4 0.7 2.0 2 0 0 2 2 2 0 Poxvirus A12 protein zf-CRD PF17979.1 ETO25603.1 - 0.012 15.8 0.1 0.02 15.0 0.1 1.4 1 0 0 1 1 1 0 Cysteine rich domain with multizinc binding regions Ost5 PF05251.12 ETO25603.1 - 0.15 12.4 0.2 0.39 11.0 0.2 1.7 1 0 0 1 1 1 0 Oligosaccharyltransferase subunit 5 SNF2_N PF00176.23 ETO25604.1 - 0.00018 20.3 0.0 0.00029 19.7 0.0 1.3 1 0 0 1 1 1 1 SNF2 family N-terminal domain SNF2_N PF00176.23 ETO25605.1 - 1.9e-21 76.2 0.2 2.4e-21 75.8 0.2 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain DUF3622 PF12286.8 ETO25607.1 - 0.049 14.0 0.1 0.084 13.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3622) zf-U1 PF06220.12 ETO25609.1 - 0.8 9.5 3.7 1.9 8.3 0.1 2.4 2 0 0 2 2 2 0 U1 zinc finger DUF4083 PF13314.6 ETO25610.1 - 6.8 6.7 7.3 2 8.5 2.1 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4083) Mito_carr PF00153.27 ETO25611.1 - 1.7e-24 85.5 8.2 2.1e-14 53.2 0.1 2.6 1 1 1 2 2 2 2 Mitochondrial carrier protein PH PF00169.29 ETO25612.1 - 0.0011 19.5 0.1 0.0037 17.7 0.1 1.9 1 0 0 1 1 1 1 PH domain Sporozoite_P67 PF05642.11 ETO25612.1 - 1.1 7.2 15.3 0.017 13.2 7.6 1.7 2 0 0 2 2 2 0 Sporozoite P67 surface antigen PPL5 PF18168.1 ETO25612.1 - 3.2 6.9 9.7 4.8 6.4 6.2 2.2 2 0 0 2 2 2 0 Prim-pol family 5 CCSAP PF15748.5 ETO25612.1 - 7.3 6.7 28.6 1.3 9.1 6.9 2.2 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated DUF3139 PF11337.8 ETO25613.1 - 0.014 16.0 1.0 0.026 15.1 1.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) Baculo_11_kDa PF06143.11 ETO25613.1 - 0.056 13.0 0.6 0.12 12.0 0.6 1.5 1 0 0 1 1 1 0 Baculovirus 11 kDa family DUF5385 PF17359.2 ETO25613.1 - 0.091 12.3 2.6 0.15 11.6 2.6 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) WBP-1 PF11669.8 ETO25613.1 - 0.21 12.2 0.1 0.21 12.2 0.1 2.3 3 1 1 4 4 4 0 WW domain-binding protein 1 Macoilin PF09726.9 ETO25613.1 - 0.36 9.3 6.2 0.48 8.9 6.2 1.3 1 0 0 1 1 1 0 Macoilin family DUF4834 PF16118.5 ETO25613.1 - 2.2 9.3 9.7 0.31 12.0 0.9 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RIFIN PF02009.16 ETO25613.1 - 7.9 6.3 10.9 2.1 8.2 5.2 2.2 2 0 0 2 2 2 0 Rifin SWIB PF02201.18 ETO25614.1 - 9.3e-05 22.2 0.0 0.00024 20.9 0.0 1.8 1 0 0 1 1 1 1 SWIB/MDM2 domain IRK PF01007.20 ETO25614.1 - 0.79 9.5 6.0 2.9 7.7 5.5 2.0 1 1 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain NST1 PF13945.6 ETO25615.1 - 0.1 12.7 5.4 0.23 11.6 5.4 1.6 1 0 0 1 1 1 0 Salt tolerance down-regulator DSPc PF00782.20 ETO25617.1 - 3.8e-19 68.8 1.7 8.4e-19 67.7 0.2 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO25617.1 - 9.4e-05 22.1 0.0 0.00024 20.8 0.0 1.6 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETO25617.1 - 0.0014 18.9 0.1 0.062 13.6 0.0 2.4 2 0 0 2 2 2 1 Rit1 DUSP-like domain NAD_binding_1 PF00175.21 ETO25618.1 - 4.5e-25 88.4 0.0 8.6e-25 87.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETO25618.1 - 6e-07 29.7 0.0 2.1e-06 28.0 0.0 1.8 2 0 0 2 2 2 1 Ferric reductase NAD binding domain DHHA1 PF02272.19 ETO25619.1 - 9.2e-06 26.1 0.7 1.6e-05 25.3 0.7 1.4 1 0 0 1 1 1 1 DHHA1 domain Glyco_hydro_31 PF01055.26 ETO25621.1 - 3.1e-11 43.1 2.0 5.4e-11 42.3 0.1 1.9 2 0 0 2 2 2 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 ETO25621.1 - 4.9e-08 33.1 1.9 1.1e-07 31.9 1.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Glyco_hydro_31 PF01055.26 ETO25622.1 - 7.3e-11 41.9 0.1 8.1e-11 41.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Laminin_B PF00052.18 ETO25622.1 - 0.099 12.5 0.1 0.19 11.6 0.0 1.5 1 1 0 1 1 1 0 Laminin B (Domain IV) Glyco_hydro_31 PF01055.26 ETO25623.1 - 6.7e-16 58.5 0.2 1.3e-15 57.6 0.2 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 WD40 PF00400.32 ETO25624.1 - 1.9e-64 212.0 36.4 9.6e-09 35.7 0.7 11.6 11 0 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25624.1 - 8.2e-20 70.9 6.9 0.0014 18.8 0.1 8.3 4 3 5 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO25624.1 - 9.6e-11 41.0 14.6 0.045 12.4 0.1 7.5 4 2 4 8 8 8 6 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO25624.1 - 1.6e-06 27.4 1.7 0.00016 20.8 0.1 4.4 3 2 2 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO25624.1 - 0.0002 20.8 16.1 0.1 11.9 0.4 5.9 3 1 3 7 7 7 3 WD40-like domain Nucleoporin_N PF08801.11 ETO25624.1 - 0.00034 19.5 17.8 0.91 8.2 0.3 6.4 5 2 1 7 7 7 4 Nup133 N terminal like PD40 PF07676.12 ETO25624.1 - 0.049 13.6 1.0 9.1 6.4 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF4220 PF13968.6 ETO25626.1 - 0.043 13.2 1.4 0.047 13.1 1.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4220) CLN3 PF02487.17 ETO25626.1 - 0.11 11.5 6.6 0.11 11.5 6.6 1.0 1 0 0 1 1 1 0 CLN3 protein PTPRCAP PF15713.5 ETO25626.1 - 0.11 12.7 12.9 0.14 12.5 12.9 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated LRR19-TM PF15176.6 ETO25626.1 - 0.25 11.4 7.9 0.046 13.7 4.7 1.4 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Kei1 PF08552.11 ETO25626.1 - 0.42 10.5 4.0 0.54 10.1 4.0 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 CDC45 PF02724.14 ETO25626.1 - 1.1 7.4 14.1 1.3 7.2 14.1 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO25626.1 - 1.3 7.7 12.4 1.4 7.6 12.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4912 PF16258.5 ETO25626.1 - 1.9 8.7 8.0 41 4.4 8.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4912) DUF4094 PF13334.6 ETO25626.1 - 2.3 8.7 8.6 1.1 9.8 3.3 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) Spt20 PF12090.8 ETO25626.1 - 2.9 7.4 16.7 3.5 7.2 16.7 1.1 1 0 0 1 1 1 0 Spt20 family O-antigen_lig PF13425.6 ETO25626.1 - 3.3 6.4 8.3 3.5 6.3 8.3 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Neur_chan_memb PF02932.16 ETO25626.1 - 4 7.4 8.0 4.5 7.3 8.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region HSP70 PF00012.20 ETO25626.1 - 5.9 4.9 11.9 6.7 4.8 11.9 1.0 1 0 0 1 1 1 0 Hsp70 protein ALMT PF11744.8 ETO25626.1 - 7.7 5.2 9.4 8.4 5.1 9.4 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 ETO25626.1 - 8.8 6.1 16.8 11 5.8 16.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Myotub-related PF06602.14 ETO25627.1 - 1.8e-130 435.0 0.8 3.7e-130 434.0 0.8 1.5 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain DSPc PF00782.20 ETO25627.1 - 0.0012 18.7 2.1 0.0012 18.7 0.1 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain 3-PAP PF12578.8 ETO25627.1 - 0.0021 17.8 0.3 0.0021 17.8 0.3 1.9 2 0 0 2 2 2 1 Myotubularin-associated protein Y_phosphatase PF00102.27 ETO25627.1 - 0.0043 16.6 0.1 0.012 15.2 0.1 1.7 1 0 0 1 1 1 1 Protein-tyrosine phosphatase GRAM PF02893.20 ETO25627.1 - 0.0056 16.5 0.1 0.014 15.2 0.1 1.6 1 0 0 1 1 1 1 GRAM domain Y_phosphatase3 PF13350.6 ETO25627.1 - 0.018 15.0 0.8 0.031 14.2 0.0 1.7 2 0 0 2 2 2 0 Tyrosine phosphatase family Nop PF01798.18 ETO25628.1 - 2.5e-60 203.8 0.3 2.5e-60 203.8 0.3 2.3 2 0 0 2 2 2 1 snoRNA binding domain, fibrillarin Phage_30_8 PF06019.11 ETO25628.1 - 0.95 9.4 0.0 0.95 9.4 0.0 2.3 2 0 0 2 2 2 0 Phage GP30.8 protein RINT1_TIP1 PF04437.13 ETO25629.1 - 2.2e-05 23.6 2.5 4.2e-05 22.6 2.5 1.5 1 1 0 1 1 1 1 RINT-1 / TIP-1 family DUF3932 PF13068.6 ETO25629.1 - 0.12 12.7 0.4 3.5 8.0 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3932) Vps53_N PF04100.12 ETO25630.1 - 1.2e-33 116.6 10.6 1.3e-33 116.5 10.6 1.0 1 0 0 1 1 1 1 Vps53-like, N-terminal CENP-K PF11802.8 ETO25630.1 - 0.028 14.0 15.6 0.21 11.1 11.1 2.1 1 1 1 2 2 2 0 Centromere-associated protein K Baculo_PEP_C PF04513.12 ETO25630.1 - 0.03 14.4 0.4 0.065 13.3 0.2 1.6 1 1 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus LMBR1 PF04791.16 ETO25630.1 - 4.9 5.9 5.7 5.6 5.8 5.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein RecG_N PF17190.4 ETO25630.1 - 5.2 7.9 11.0 6.9 7.5 0.4 2.8 2 1 0 2 2 2 0 RecG N-terminal helical domain YlbD_coat PF14071.6 ETO25630.1 - 5.5 7.3 13.9 15 5.8 9.0 2.6 1 1 2 3 3 3 0 Putative coat protein Seryl_tRNA_N PF02403.22 ETO25630.1 - 9 6.6 18.0 27 5.0 14.6 2.3 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Vps53_N PF04100.12 ETO25631.1 - 3.2e-30 105.4 1.5 4.2e-30 105.0 1.5 1.1 1 0 0 1 1 1 1 Vps53-like, N-terminal AAA_32 PF13654.6 ETO25633.1 - 0.047 12.5 0.2 0.089 11.6 0.2 1.3 1 0 0 1 1 1 0 AAA domain Mlh1_C PF16413.5 ETO25633.1 - 0.074 12.4 3.4 0.074 12.4 0.2 2.5 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus WD40 PF00400.32 ETO25634.1 - 1.1e-54 181.2 20.2 1.7e-09 38.1 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25634.1 - 7.8e-17 61.4 1.1 0.0023 18.2 0.0 6.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25634.1 - 2.1e-11 43.4 2.1 0.4 9.6 0.0 6.6 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO25634.1 - 1.1e-10 41.3 1.5 0.0035 16.7 0.0 3.4 2 2 1 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO25634.1 - 9.1e-08 32.2 1.3 0.016 15.1 0.0 3.2 1 1 4 5 5 5 5 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO25634.1 - 3.3e-07 29.3 3.9 0.014 14.0 0.4 3.8 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Phage_CI_repr PF07022.13 ETO25634.1 - 0.0002 21.3 0.1 0.14 12.3 0.0 3.3 3 0 0 3 3 3 1 Bacteriophage CI repressor helix-turn-helix domain Cytochrom_D1 PF02239.16 ETO25634.1 - 0.00053 18.6 0.2 0.016 13.8 0.1 2.4 2 1 0 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO25634.1 - 0.00065 19.6 3.9 2.6 8.1 0.2 4.9 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF4566 PF15130.6 ETO25634.1 - 0.019 14.4 0.1 0.042 13.3 0.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4566) Frtz PF11768.8 ETO25634.1 - 0.037 12.3 0.1 0.75 8.0 0.0 2.3 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz PQQ PF01011.21 ETO25634.1 - 0.16 12.0 2.2 44 4.3 0.0 4.4 5 1 1 6 6 6 0 PQQ enzyme repeat Kinesin PF00225.23 ETO25635.1 - 2.9e-32 111.9 0.1 3.9e-32 111.5 0.1 1.2 1 0 0 1 1 1 1 Kinesin motor domain GatB_Yqey PF02637.18 ETO25635.1 - 0.0025 17.7 0.4 0.25 11.2 0.0 2.1 2 0 0 2 2 2 2 GatB domain DUF1192 PF06698.11 ETO25635.1 - 0.0048 16.9 0.2 0.01 15.9 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) Cep57_MT_bd PF06657.13 ETO25635.1 - 0.019 15.4 0.7 0.27 11.7 0.2 2.2 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF5082 PF16888.5 ETO25635.1 - 0.027 14.7 2.3 0.069 13.4 2.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) ZapB PF06005.12 ETO25636.1 - 0.002 18.5 7.6 0.002 18.5 7.6 5.1 5 2 1 6 6 6 1 Cell division protein ZapB FlxA PF14282.6 ETO25636.1 - 0.038 14.0 1.4 0.038 14.0 1.4 4.9 4 1 0 5 5 5 0 FlxA-like protein YabA PF06156.13 ETO25636.1 - 0.04 14.6 4.8 0.04 14.6 4.8 5.0 3 1 1 5 5 5 0 Initiation control protein YabA Osmo_CC PF08946.10 ETO25636.1 - 0.062 13.6 4.3 1.4 9.2 0.1 3.7 3 0 0 3 3 3 0 Osmosensory transporter coiled coil FokI_N PF02981.15 ETO25636.1 - 0.65 10.2 3.9 1.3 9.2 0.3 2.9 2 2 1 3 3 3 0 Restriction endonuclease FokI, recognition domain NPV_P10 PF05531.12 ETO25636.1 - 1.5 9.3 14.3 0.18 12.3 1.6 3.8 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein DASH_Dam1 PF08653.10 ETO25636.1 - 6.9 6.6 12.8 0.17 11.7 1.2 3.7 3 1 1 4 4 4 0 DASH complex subunit Dam1 TMPIT PF07851.13 ETO25636.1 - 9.5 5.4 36.6 0.93 8.7 7.9 3.4 1 1 2 3 3 3 0 TMPIT-like protein WD40 PF00400.32 ETO25637.1 - 5.8e-06 26.9 0.0 0.0042 17.9 0.0 2.9 2 0 0 2 2 2 1 WD domain, G-beta repeat TPR_1 PF00515.28 ETO25637.1 - 4.4e-05 23.1 4.5 0.02 14.7 0.3 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO25637.1 - 0.00013 22.5 0.0 0.00023 21.8 0.0 1.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO25637.1 - 0.00025 20.9 0.3 0.31 11.3 0.0 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat Gti1_Pac2 PF09729.9 ETO25637.1 - 0.0046 17.1 2.5 0.0046 17.1 2.5 2.2 2 0 0 2 2 2 1 Gti1/Pac2 family TPR_19 PF14559.6 ETO25637.1 - 0.005 17.3 0.0 0.018 15.5 0.0 1.9 1 1 1 2 2 2 1 Tetratricopeptide repeat DUF913 PF06025.12 ETO25637.1 - 0.75 8.7 7.7 0.79 8.6 0.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO25637.1 - 2.8 7.1 6.2 2.7 7.1 0.3 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Presenilin PF01080.17 ETO25637.1 - 2.9 6.6 7.8 2.2 6.9 0.8 2.1 2 0 0 2 2 2 0 Presenilin Kelch_1 PF01344.25 ETO25638.1 - 8.9e-08 31.6 0.3 0.0046 16.5 0.0 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO25638.1 - 4.7e-06 26.7 8.3 0.12 12.8 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO25638.1 - 0.0009 19.1 0.0 0.65 10.1 0.0 4.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO25638.1 - 0.0012 18.8 0.1 0.11 12.5 0.0 3.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO25638.1 - 0.026 14.8 3.8 0.41 11.0 0.0 3.9 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO25638.1 - 0.12 12.4 10.4 1.8 8.6 0.0 4.7 4 0 0 4 4 4 0 Kelch motif Chlam_PMP PF02415.17 ETO25638.1 - 2.9 8.5 40.6 1.3 9.6 0.0 9.6 11 0 0 11 11 11 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat Peptidase_C14 PF00656.22 ETO25639.1 - 7.6e-15 55.5 0.3 1.3e-14 54.8 0.3 1.3 1 0 0 1 1 1 1 Caspase domain Kelch_1 PF01344.25 ETO25640.1 - 0.0028 17.2 2.7 2.1 8.0 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO25640.1 - 0.009 16.3 3.2 7.1 7.1 0.0 4.5 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.15 ETO25640.1 - 0.034 14.1 0.7 13 6.0 0.1 4.0 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO25640.1 - 1.3 9.0 7.2 20 5.3 0.3 4.5 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO25641.1 - 1.1e-61 203.3 19.3 1.4e-09 38.4 0.3 7.7 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25641.1 - 6.5e-25 87.3 1.7 0.00062 20.0 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25641.1 - 5e-12 45.4 3.6 0.0013 17.7 0.2 5.2 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO25641.1 - 3.9e-10 39.0 8.1 0.58 8.7 0.1 5.7 2 1 2 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO25641.1 - 1.2e-09 38.0 4.9 0.015 14.7 0.0 4.4 2 1 2 4 4 4 3 WD40-like domain Utp8 PF10395.9 ETO25641.1 - 8.6e-05 21.3 0.4 0.041 12.4 0.3 2.7 1 1 2 3 3 3 2 Utp8 family Cytochrom_D1 PF02239.16 ETO25641.1 - 0.00014 20.5 1.7 0.17 10.3 0.0 3.2 1 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO25641.1 - 0.00021 21.2 1.2 11 6.1 0.0 5.3 5 1 0 5 5 5 0 WD40-like Beta Propeller Repeat Kelch_4 PF13418.6 ETO25641.1 - 0.00028 20.8 1.8 0.0034 17.4 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO25641.1 - 0.0018 18.5 6.7 0.045 14.0 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Proteasome_A_N PF10584.9 ETO25641.1 - 0.0037 16.9 4.4 1.3 8.8 0.0 4.3 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Kelch_2 PF07646.15 ETO25641.1 - 0.013 15.5 2.3 0.04 13.9 0.1 3.0 3 0 0 3 3 3 0 Kelch motif Nbas_N PF15492.6 ETO25641.1 - 0.033 13.5 1.1 4.2 6.6 0.0 3.4 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Kelch_1 PF01344.25 ETO25641.1 - 0.037 13.6 1.4 0.14 11.7 0.5 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO25641.1 - 0.047 13.7 1.4 0.047 13.7 1.4 3.0 4 0 0 4 4 4 0 Kelch motif NHL PF01436.21 ETO25641.1 - 0.059 13.4 1.4 3.6 7.8 0.1 3.1 2 0 0 2 2 2 0 NHL repeat ComS PF17584.2 ETO25641.1 - 0.14 11.7 0.3 1.1 8.9 0.2 2.5 2 0 0 2 2 2 0 Bacillus competence protein S PH PF00169.29 ETO25642.1 - 2.7e-09 37.5 2.7 4.5e-09 36.8 0.6 2.5 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO25642.1 - 0.00027 21.1 0.3 0.001 19.3 0.3 2.1 1 0 0 1 1 1 1 Pleckstrin homology domain PH_6 PF15406.6 ETO25642.1 - 0.0086 16.4 0.1 0.0086 16.4 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain EMC3_TMCO1 PF01956.16 ETO25642.1 - 0.025 14.3 0.3 0.17 11.6 0.0 2.3 2 1 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Shugoshin_N PF07558.11 ETO25642.1 - 0.14 12.0 12.1 3.9 7.4 2.1 4.2 4 0 0 4 4 4 0 Shugoshin N-terminal coiled-coil region FlxA PF14282.6 ETO25642.1 - 0.31 11.0 34.7 0.053 13.5 19.6 3.6 3 0 0 3 3 3 0 FlxA-like protein BNIP2 PF12496.8 ETO25642.1 - 0.92 9.9 9.2 0.7 10.3 6.6 2.2 2 0 0 2 2 2 0 Bcl2-/adenovirus E1B nineteen kDa-interacting protein 2 FAD-SLDH PF12318.8 ETO25642.1 - 1.6 8.8 8.2 0.37 10.9 4.3 2.0 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase Med27 PF11571.8 ETO25642.1 - 1.7 9.1 4.9 5.4 7.5 0.3 3.4 2 1 0 3 3 3 0 Mediator complex subunit 27 Fungal_trans_2 PF11951.8 ETO25642.1 - 3.5 6.3 8.5 5 5.8 7.4 1.8 1 1 0 1 1 1 0 Fungal specific transcription factor domain DUF4407 PF14362.6 ETO25642.1 - 4.1 6.7 22.9 11 5.3 18.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Reticulon PF02453.17 ETO25643.1 - 0.00045 20.2 0.3 0.00066 19.7 0.3 1.3 1 0 0 1 1 1 1 Reticulon Gal-bind_lectin PF00337.22 ETO25643.1 - 0.0011 18.4 0.1 0.0013 18.3 0.1 1.3 1 1 0 1 1 1 1 Galactoside-binding lectin TDA11 PF17084.5 ETO25643.1 - 0.0024 16.9 0.3 0.0024 16.9 0.3 1.6 2 0 0 2 2 2 1 Topoisomerase I damage affected protein 11 EVI2A PF05399.11 ETO25643.1 - 0.0046 16.6 1.9 0.0067 16.0 1.9 1.3 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) DUF2207 PF09972.9 ETO25643.1 - 0.04 12.7 5.1 0.05 12.4 5.1 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF948 PF06103.11 ETO25643.1 - 0.086 13.1 3.8 0.72 10.1 0.0 2.8 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) Pox_A_type_inc PF04508.12 ETO25643.1 - 0.13 12.2 0.5 1.9 8.5 0.1 2.7 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat tRNA_lig_CPD PF08302.11 ETO25643.1 - 0.13 11.7 6.1 0.22 10.9 6.1 1.3 1 0 0 1 1 1 0 Fungal tRNA ligase phosphodiesterase domain LapA_dom PF06305.11 ETO25643.1 - 0.23 11.3 0.1 0.23 11.3 0.1 3.0 2 1 0 2 2 1 0 Lipopolysaccharide assembly protein A domain HBM PF16591.5 ETO25643.1 - 0.27 10.6 8.7 0.06 12.8 2.5 2.4 2 1 1 3 3 3 0 Helical bimodular sensor domain DUF745 PF05335.13 ETO25643.1 - 0.78 9.4 16.7 0.75 9.5 11.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF745) CENP-O PF09496.10 ETO25643.1 - 2.3 8.2 7.5 1.1 9.2 3.0 2.1 2 0 0 2 2 2 0 Cenp-O kinetochore centromere component LRRFIP PF09738.9 ETO25643.1 - 4.5 6.7 16.7 0.72 9.3 9.3 2.2 2 0 0 2 2 2 0 LRRFIP family Golgin_A5 PF09787.9 ETO25643.1 - 7.1 6.0 20.0 1.1 8.7 12.8 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 PCO_ADO PF07847.12 ETO25644.1 - 1.2e-17 64.1 1.6 1.5e-16 60.5 1.6 2.0 1 1 0 1 1 1 1 PCO_ADO CENP-I PF07778.11 ETO25644.1 - 0.0057 15.4 0.3 0.0068 15.2 0.3 1.1 1 0 0 1 1 1 1 Mis6 RabGAP-TBC PF00566.18 ETO25645.1 - 2.1e-11 43.9 0.5 2.1e-11 43.9 0.5 3.8 3 1 0 3 3 3 1 Rab-GTPase-TBC domain Rubrerythrin PF02915.17 ETO25645.1 - 1.1 9.6 12.5 0.3 11.5 8.7 2.0 2 0 0 2 2 2 0 Rubrerythrin Peptidase_M22 PF00814.25 ETO25646.1 - 5.5e-75 252.6 0.2 1.2e-74 251.4 0.2 1.5 1 1 0 1 1 1 1 Glycoprotease family Carbam_trans_N PF02543.15 ETO25646.1 - 0.022 14.4 0.1 0.03 14.0 0.1 1.2 1 0 0 1 1 1 0 Carbamoyltransferase N-terminus Galactosyl_T PF01762.21 ETO25647.1 - 2.4e-08 34.0 3.3 5.4e-08 32.9 3.3 1.6 1 1 0 1 1 1 1 Galactosyltransferase MIF4G PF02854.19 ETO25649.1 - 3.2e-21 75.9 6.6 5.1e-19 68.7 3.0 3.4 2 1 0 2 2 2 1 MIF4G domain MA3 PF02847.17 ETO25649.1 - 0.089 12.8 0.5 0.98 9.4 0.1 2.8 3 0 0 3 3 3 0 MA3 domain EF-hand_3 PF09069.11 ETO25649.1 - 0.093 13.2 0.2 11 6.5 0.0 3.4 3 0 0 3 3 3 0 EF-hand SPRY PF00622.28 ETO25650.1 - 0.023 14.8 0.2 0.034 14.3 0.2 1.2 1 0 0 1 1 1 0 SPRY domain fn3 PF00041.21 ETO25651.1 - 0.00023 21.4 0.0 0.00055 20.2 0.0 1.5 1 0 0 1 1 1 1 Fibronectin type III domain Pur_ac_phosph_N PF16656.5 ETO25651.1 - 0.0014 19.1 0.0 0.0025 18.3 0.0 1.4 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain NINJA_B PF16136.5 ETO25652.1 - 0.16 12.3 0.4 0.19 12.1 0.4 1.1 1 0 0 1 1 1 0 Putative nuclear localisation signal PH PF00169.29 ETO25653.1 - 1.2e-13 51.4 2.2 2e-13 50.8 2.2 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO25653.1 - 2.8e-05 24.5 1.7 2.8e-05 24.5 1.7 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain PH_6 PF15406.6 ETO25653.1 - 0.0016 18.7 0.2 0.0045 17.3 0.0 1.8 2 0 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO25653.1 - 0.0018 18.3 2.0 0.0018 18.3 2.0 1.9 1 1 1 2 2 2 1 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 ETO25653.1 - 0.0023 17.8 1.7 0.0023 17.8 1.7 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ETO25653.1 - 0.0035 17.6 2.3 0.026 14.8 2.3 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PMAIP1 PF15150.6 ETO25653.1 - 0.074 12.9 2.4 0.094 12.6 0.2 2.2 2 0 0 2 2 2 0 Phorbol-12-myristate-13-acetate-induced PH_4 PF15404.6 ETO25653.1 - 4 7.2 8.1 0.082 12.7 0.6 2.0 3 0 0 3 3 3 0 Pleckstrin homology domain DUF2457 PF10446.9 ETO25654.1 - 0.61 9.2 14.6 0.86 8.7 14.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO25654.1 - 6.3 4.8 9.9 8.3 4.4 9.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF4559 PF15112.6 ETO25656.1 - 0.00025 20.9 7.6 0.00027 20.7 7.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4559) AAA_23 PF13476.6 ETO25656.1 - 0.13 12.7 11.8 0.14 12.6 11.8 1.1 1 0 0 1 1 1 0 AAA domain YabA PF06156.13 ETO25656.1 - 0.91 10.2 9.0 1.6 9.4 8.4 1.8 1 1 1 2 2 2 0 Initiation control protein YabA MLANA PF14991.6 ETO25657.1 - 0.014 15.6 1.8 0.02 15.2 0.0 1.9 2 0 0 2 2 2 0 Protein melan-A EphA2_TM PF14575.6 ETO25657.1 - 0.089 13.7 1.2 0.22 12.4 1.2 1.9 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Podoplanin PF05808.11 ETO25657.1 - 4.4 7.4 6.6 0.48 10.5 0.4 2.2 1 1 2 3 3 3 0 Podoplanin rve PF00665.26 ETO25658.1 - 0.00077 19.6 0.0 0.0014 18.8 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain rve_3 PF13683.6 ETO25658.1 - 0.0074 16.0 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 Integrase core domain DDE_Tnp_1_2 PF13586.6 ETO25658.1 - 0.13 12.7 0.0 0.32 11.4 0.0 1.7 1 0 0 1 1 1 0 Transposase DDE domain Herpes_LMP1 PF05297.11 ETO25659.1 - 0.097 11.9 6.6 0.26 10.4 6.3 1.6 1 1 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF2070 PF09843.9 ETO25659.1 - 0.32 9.2 4.2 0.44 8.8 4.2 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4551 PF15087.6 ETO25660.1 - 0.62 8.8 5.0 0.85 8.4 5.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) RHD_DNA_bind PF00554.22 ETO25661.1 - 0.079 12.9 0.1 0.098 12.6 0.1 1.1 1 0 0 1 1 1 0 Rel homology DNA-binding domain DUF4470 PF14737.6 ETO25661.1 - 0.099 12.8 0.1 0.73 10.0 0.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4470) Helicase_C PF00271.31 ETO25662.1 - 2e-24 86.1 0.5 7e-24 84.3 0.0 2.2 2 1 1 3 3 3 1 Helicase conserved C-terminal domain GPS2_interact PF15784.5 ETO25662.1 - 0.0051 17.2 6.8 0.012 16.1 6.8 1.6 1 0 0 1 1 1 1 G-protein pathway suppressor 2-interacting domain Ly49 PF08391.10 ETO25662.1 - 0.026 14.9 1.5 0.057 13.8 1.5 1.5 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region UvrD-helicase PF00580.21 ETO25662.1 - 0.03 13.9 2.2 0.036 13.6 2.2 1.1 1 0 0 1 1 1 0 UvrD/REP helicase N-terminal domain DUF2730 PF10805.8 ETO25662.1 - 0.056 13.5 0.7 0.098 12.8 0.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) XPC-binding PF09280.11 ETO25662.1 - 0.11 12.2 1.1 0.32 10.8 1.1 1.7 1 0 0 1 1 1 0 XPC-binding domain DEAD PF00270.29 ETO25663.1 - 6.4e-25 87.9 0.1 8.7e-25 87.5 0.1 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO25663.1 - 0.016 15.2 0.0 0.027 14.5 0.0 1.4 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit DUF2722 PF10846.8 ETO25664.1 - 1.1e-06 27.9 15.1 1.1e-06 27.9 15.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF2722) DUF4667 PF15700.5 ETO25664.1 - 0.00032 20.9 8.2 0.00032 20.9 8.2 3.2 3 0 0 3 3 3 2 Domain of unknown function (DUF4667) DUF3446 PF11928.8 ETO25664.1 - 0.013 15.7 32.2 0.067 13.5 11.2 3.0 4 0 0 4 4 4 0 Early growth response N-terminal domain Hid1 PF12722.7 ETO25664.1 - 0.054 11.6 34.6 0.053 11.7 10.7 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein SLC12 PF03522.15 ETO25664.1 - 0.086 11.9 19.7 0.3 10.1 12.1 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Spore_coat_CotO PF14153.6 ETO25664.1 - 0.53 10.2 15.3 0.024 14.6 5.0 2.3 2 0 0 2 2 2 0 Spore coat protein CotO Chorion_2 PF03964.15 ETO25664.1 - 1.6 9.6 14.5 1.6 9.6 3.7 2.7 2 0 0 2 2 2 0 Chorion family 2 DUF3123 PF11321.8 ETO25664.1 - 1.8 9.3 0.0 1.8 9.3 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF3123) Vps8 PF12816.7 ETO25665.1 - 3.6e-34 118.0 2.7 5.9e-34 117.3 2.7 1.4 1 1 0 1 1 1 1 Golgi CORVET complex core vacuolar protein 8 YjeF_N PF03853.15 ETO25666.1 - 5.7e-19 68.6 0.0 6.8e-19 68.4 0.0 1.1 1 0 0 1 1 1 1 YjeF-related protein N-terminus Cytomega_gL PF01801.16 ETO25666.1 - 0.018 14.4 0.1 0.04 13.3 0.0 1.5 2 0 0 2 2 2 0 Cytomegalovirus glycoprotein L TFIIA PF03153.13 ETO25667.1 - 0.31 11.0 19.5 0.21 11.5 5.9 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit Ribosomal_S8e PF01201.22 ETO25667.1 - 0.73 10.0 5.3 9.3 6.4 5.1 2.6 1 1 0 1 1 1 0 Ribosomal protein S8e PHC2_SAM_assoc PF16616.5 ETO25667.1 - 9 7.1 15.9 2.2 9.1 5.9 2.7 2 1 0 2 2 2 0 Unstructured region on Polyhomeotic-like protein 1 and 2 Globin PF00042.22 ETO25668.1 - 8.8e-12 45.6 3.2 1.5e-08 35.1 0.3 2.5 2 1 0 2 2 2 2 Globin NB-ARC PF00931.22 ETO25670.1 - 0.013 14.7 0.4 0.015 14.5 0.4 1.1 1 0 0 1 1 1 0 NB-ARC domain Methyltransf_25 PF13649.6 ETO25671.1 - 1.9e-07 31.7 0.2 1.7e-06 28.7 0.0 2.5 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO25671.1 - 7.4e-06 26.5 0.1 2.3e-05 25.0 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO25671.1 - 0.0016 19.1 0.0 0.0038 17.9 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO25671.1 - 0.0078 16.0 0.0 0.036 13.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ETO25671.1 - 0.022 14.3 0.0 0.041 13.4 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase small domain DUF2505 PF10698.9 ETO25671.1 - 0.17 12.0 0.1 0.28 11.3 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2505) JIP_LZII PF16471.5 ETO25674.1 - 0.13 12.4 3.8 1.4 9.2 0.3 2.6 2 1 0 2 2 2 0 JNK-interacting protein leucine zipper II Chibby PF14645.6 ETO25674.1 - 0.66 10.4 5.7 0.55 10.7 4.1 1.7 1 1 1 2 2 2 0 Chibby family Pkinase PF00069.25 ETO25675.1 - 2e-56 191.3 3.9 1.2e-55 188.7 0.5 2.9 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25675.1 - 1.8e-25 89.7 6.4 8.8e-19 67.8 0.8 2.6 3 0 0 3 3 3 2 Protein tyrosine kinase LMBR1 PF04791.16 ETO25675.1 - 0.07 12.0 0.4 0.27 10.1 0.4 1.9 1 1 0 1 1 1 0 LMBR1-like membrane protein DSPn PF14671.6 ETO25676.1 - 0.0013 19.2 0.4 0.0028 18.1 0.4 1.6 1 0 0 1 1 1 1 Dual specificity protein phosphatase, N-terminal half DUF4138 PF13595.6 ETO25676.1 - 0.019 14.2 1.7 0.034 13.4 1.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4138) RsfS PF02410.15 ETO25676.1 - 0.026 14.9 0.1 0.14 12.6 0.1 2.3 1 1 0 1 1 1 0 Ribosomal silencing factor during starvation Vps51 PF08700.11 ETO25676.1 - 0.051 13.6 0.6 0.15 12.1 0.6 1.8 1 0 0 1 1 1 0 Vps51/Vps67 O-FucT PF10250.9 ETO25678.1 - 2.4e-17 63.7 0.0 5.7e-17 62.4 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase SDA1 PF05285.12 ETO25678.1 - 0.52 9.7 31.1 0.75 9.2 31.1 1.1 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 ETO25678.1 - 0.85 8.3 13.9 1.3 7.7 13.9 1.2 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO25678.1 - 0.91 7.6 29.5 1.3 7.2 29.5 1.1 1 0 0 1 1 1 0 Nop14-like family SAPS PF04499.15 ETO25678.1 - 1.1 8.0 17.5 1.6 7.4 17.5 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO25678.1 - 3.2 5.9 23.3 5.3 5.2 23.3 1.3 1 0 0 1 1 1 0 CDC45-like protein CCSAP PF15748.5 ETO25678.1 - 4 7.5 13.2 4.1 7.5 10.7 1.9 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated SLC12 PF03522.15 ETO25678.1 - 5.1 6.0 14.1 7.5 5.4 14.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 TIM21 PF08294.11 ETO25679.1 - 1.3e-09 38.1 0.7 2.2e-08 34.1 0.7 2.2 1 1 0 1 1 1 1 TIM21 Coa1 PF08695.10 ETO25679.1 - 4.8e-05 23.1 0.0 7.8e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 Cytochrome oxidase complex assembly protein 1 Myosin_head PF00063.21 ETO25680.1 - 8.8e-189 629.0 0.4 2.4e-188 627.5 0.4 1.7 1 1 0 1 1 1 1 Myosin head (motor domain) Mac PF12464.8 ETO25680.1 - 0.075 13.3 0.3 0.27 11.5 0.3 1.9 1 0 0 1 1 1 0 Maltose acetyltransferase KIP1 PF07765.12 ETO25680.1 - 0.71 10.0 3.8 4.2 7.6 0.7 3.3 3 0 0 3 3 3 0 KIP1-like protein FAM60A PF15396.6 ETO25684.1 - 0.0015 18.6 10.9 0.0015 18.6 10.9 1.7 2 0 0 2 2 2 1 Protein Family FAM60A SR-25 PF10500.9 ETO25684.1 - 0.023 14.3 15.8 0.066 12.8 15.8 1.7 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Pex14_N PF04695.13 ETO25684.1 - 0.027 15.2 6.7 0.056 14.1 6.7 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region NPR3 PF03666.13 ETO25684.1 - 0.046 12.5 14.7 0.085 11.6 14.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO25684.1 - 0.054 12.3 13.1 0.085 11.6 13.1 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO25684.1 - 0.078 12.2 6.6 0.11 11.7 6.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF3762 PF12591.8 ETO25684.1 - 0.14 12.4 1.5 0.18 12.1 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3762) CDC45 PF02724.14 ETO25684.1 - 0.24 9.6 10.7 0.33 9.2 10.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Band_3_cyto PF07565.13 ETO25684.1 - 1 9.1 9.2 0.46 10.2 7.0 1.5 2 0 0 2 2 2 0 Band 3 cytoplasmic domain Spore_coat_CotO PF14153.6 ETO25684.1 - 1.1 9.2 14.0 1.6 8.6 13.0 1.8 2 0 0 2 2 2 0 Spore coat protein CotO ALMT PF11744.8 ETO25684.1 - 1.8 7.3 9.1 2.7 6.7 9.1 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3499 PF12005.8 ETO25684.1 - 1.8 9.1 7.0 9.5 6.8 6.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3499) CLN3 PF02487.17 ETO25684.1 - 1.9 7.5 4.8 2.7 6.9 4.8 1.2 1 0 0 1 1 1 0 CLN3 protein SAPS PF04499.15 ETO25684.1 - 2.3 6.9 14.9 4.1 6.1 14.9 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Neur_chan_memb PF02932.16 ETO25684.1 - 2.3 8.2 14.5 0.92 9.5 11.5 1.7 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ETO25684.1 - 2.9 6.8 16.2 0.081 11.9 10.2 1.5 2 0 0 2 2 2 0 Solute carrier family 12 Hydin_ADK PF17213.3 ETO25684.1 - 3.2 8.0 10.6 6.7 6.9 10.6 1.5 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Sec62 PF03839.16 ETO25684.1 - 3.3 7.2 10.3 6.9 6.1 10.3 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 Ctr PF04145.15 ETO25684.1 - 3.8 8.1 6.5 10 6.7 6.5 1.8 1 0 0 1 1 1 0 Ctr copper transporter family DUF3527 PF12043.8 ETO25684.1 - 5.4 6.5 14.0 4.8 6.7 12.2 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3527) Paramyxo_ncap PF00973.19 ETO25684.1 - 7.4 5.4 10.5 11 4.8 10.5 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Presenilin PF01080.17 ETO25685.1 - 3.4 6.4 3.8 3.4 6.3 3.8 1.1 1 0 0 1 1 1 0 Presenilin EF-hand_8 PF13833.6 ETO25686.1 - 2.4e-16 59.3 5.3 1.5e-08 34.4 0.5 2.5 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO25686.1 - 5.8e-16 56.8 8.8 5.2e-08 31.9 0.3 3.4 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 ETO25686.1 - 1.2e-15 57.7 5.0 6.2e-08 33.0 0.9 2.6 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO25686.1 - 6.2e-13 47.6 6.6 7.1e-07 28.7 0.1 3.5 3 1 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO25686.1 - 1.4e-09 37.0 4.3 2.6e-05 23.5 0.3 2.9 2 0 0 2 2 2 2 EF hand TerB PF05099.13 ETO25686.1 - 0.00096 19.1 0.1 0.0037 17.2 0.0 1.9 1 1 1 2 2 2 1 Tellurite resistance protein TerB UPF0154 PF03672.13 ETO25686.1 - 0.003 17.6 0.0 0.068 13.2 0.0 2.2 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0154) EF-hand_4 PF12763.7 ETO25686.1 - 0.0087 16.0 1.9 0.33 10.9 0.1 2.3 1 1 1 2 2 2 1 Cytoskeletal-regulatory complex EF hand T6PP_N PF18572.1 ETO25686.1 - 0.027 14.3 0.4 0.027 14.3 0.4 1.8 2 0 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain DUF1722 PF08349.11 ETO25686.1 - 0.082 13.2 0.0 0.38 11.0 0.0 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) NPR2 PF06218.11 ETO25688.1 - 2.4e-14 53.0 1.2 3e-14 52.7 1.2 1.1 1 0 0 1 1 1 1 Nitrogen permease regulator 2 Sp38 PF07354.12 ETO25688.1 - 0.13 11.7 0.1 0.24 10.8 0.0 1.4 1 1 0 1 1 1 0 Zona-pellucida-binding protein (Sp38) Enolase_C PF00113.22 ETO25691.1 - 2.2e-119 398.1 0.6 3.3e-119 397.5 0.6 1.2 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain Enolase_N PF03952.16 ETO25691.1 - 2.9e-22 79.2 0.1 5.4e-22 78.4 0.1 1.3 1 0 0 1 1 1 1 Enolase, N-terminal domain MR_MLE_C PF13378.6 ETO25691.1 - 3.2e-06 26.9 0.0 5e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Enolase C-terminal domain-like MAAL_C PF07476.11 ETO25691.1 - 0.009 15.2 0.0 0.016 14.4 0.0 1.4 1 0 0 1 1 1 1 Methylaspartate ammonia-lyase C-terminus FlaA PF04620.12 ETO25691.1 - 0.016 14.8 0.1 0.25 11.0 0.0 2.5 3 0 0 3 3 3 0 Flagellar filament outer layer protein Flaa WD40 PF00400.32 ETO25692.1 - 4.7e-57 188.6 11.7 7.8e-10 39.2 0.2 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25692.1 - 2.7e-25 88.5 0.0 0.00012 22.3 0.0 6.2 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25692.1 - 5.6e-17 61.7 0.4 0.026 13.5 0.0 6.0 2 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO25692.1 - 1.5e-09 37.1 4.3 0.036 12.7 0.2 4.1 1 1 2 4 4 4 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO25692.1 - 4.3e-06 26.5 11.1 3.7 7.6 0.1 5.6 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO25692.1 - 0.00089 18.7 1.5 0.9 8.8 0.0 3.9 2 2 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ETO25692.1 - 0.0016 17.4 0.7 1.9 7.3 0.0 3.7 3 1 2 5 5 5 2 Partner and localizer of BRCA2 WD40 domain WD40_like PF17005.5 ETO25692.1 - 0.014 14.7 0.3 1.9 7.8 0.0 3.1 1 1 1 3 3 3 0 WD40-like domain DUF5570 PF17731.1 ETO25692.1 - 0.014 15.4 0.5 2.3 8.3 0.0 3.3 2 1 2 4 4 4 0 Family of unknown function (DUF5570) ssDBP_DBD PF18361.1 ETO25692.1 - 0.03 14.5 0.0 17 5.6 0.0 3.2 3 1 1 4 4 4 0 Single stranded DNA-binding protein ss DNA binding domain PH_TFIIH PF08567.11 ETO25692.1 - 0.097 13.0 0.2 59 4.1 0.1 3.7 4 0 0 4 4 4 0 TFIIH p62 subunit, N-terminal domain Folate_carrier PF01770.18 ETO25693.1 - 2.9e-06 26.3 12.0 3.6e-06 26.0 12.0 1.1 1 0 0 1 1 1 1 Reduced folate carrier Cytochrom_B558a PF05038.13 ETO25693.1 - 2.7 7.5 4.3 0.51 9.9 0.5 1.7 2 0 0 2 2 2 0 Cytochrome Cytochrome b558 alpha-subunit Cyclin_N PF00134.23 ETO25696.1 - 1.5e-32 112.0 2.3 1.8e-32 111.7 2.3 1.1 1 0 0 1 1 1 1 Cyclin, N-terminal domain LRR_6 PF13516.6 ETO25696.1 - 0.19 11.9 0.0 0.4 10.8 0.0 1.6 1 0 0 1 1 1 0 Leucine Rich repeat Sec8_exocyst PF04048.14 ETO25697.1 - 0.096 12.6 3.4 0.13 12.1 0.1 2.1 2 1 0 2 2 2 0 Sec8 exocyst complex component specific domain RESP18 PF14948.6 ETO25697.1 - 0.11 12.8 0.3 0.22 11.8 0.0 1.5 2 0 0 2 2 2 0 RESP18 domain PAPS_reduct PF01507.19 ETO25699.1 - 7.3e-15 55.4 0.0 1.1e-14 54.9 0.0 1.3 1 0 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family CFEM PF05730.11 ETO25699.1 - 2.4 8.3 6.2 0.27 11.4 0.4 2.1 2 0 0 2 2 2 0 CFEM domain PAPS_reduct PF01507.19 ETO25700.1 - 0.00033 20.8 0.0 0.0007 19.7 0.0 1.6 1 1 0 1 1 1 1 Phosphoadenosine phosphosulfate reductase family Protocadherin PF08374.11 ETO25701.1 - 0.013 15.5 0.1 0.013 15.5 0.1 1.7 2 0 0 2 2 2 0 Protocadherin TAP_C PF03943.13 ETO25701.1 - 0.37 10.5 2.2 0.43 10.2 1.3 1.6 2 0 0 2 2 2 0 TAP C-terminal domain Aldo_ket_red PF00248.21 ETO25702.1 - 8.9e-26 90.8 0.1 3.3e-24 85.6 0.1 2.3 2 0 0 2 2 2 2 Aldo/keto reductase family Iron_traffic PF04362.14 ETO25702.1 - 0.1 12.3 0.2 0.23 11.2 0.2 1.5 1 0 0 1 1 1 0 Bacterial Fe(2+) trafficking Amidohydro_1 PF01979.20 ETO25703.1 - 2.7e-40 138.7 0.0 3.1e-40 138.5 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase family Amidohydro_3 PF07969.11 ETO25703.1 - 6.2e-05 22.6 0.0 7.5e-05 22.4 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase family VEFS-Box PF09733.9 ETO25704.1 - 0.012 15.5 1.1 0.033 14.0 0.2 2.0 2 0 0 2 2 2 0 VEFS-Box of polycomb protein JmjN PF02375.17 ETO25705.1 - 0.0098 15.8 0.1 72 3.5 0.0 4.1 5 0 0 5 5 5 3 jmjN domain GnRH PF00446.17 ETO25705.1 - 1.6 9.3 4.6 1.1e+02 3.5 0.0 4.4 5 0 0 5 5 5 0 Gonadotropin-releasing hormone PIP5K PF01504.18 ETO25706.1 - 1.1e-27 97.0 20.5 1.6e-25 89.9 20.5 2.4 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase Zip PF02535.22 ETO25706.1 - 0.19 10.9 12.4 0.42 9.8 1.0 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter G-patch_2 PF12656.7 ETO25706.1 - 0.19 11.8 0.1 0.19 11.8 0.1 3.5 4 0 0 4 4 4 0 G-patch domain DUF5436 PF17504.2 ETO25706.1 - 1 9.7 7.3 0.18 12.1 2.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5436) Presenilin PF01080.17 ETO25706.1 - 1.4 7.6 11.8 1.1 8.0 1.1 2.1 2 0 0 2 2 2 0 Presenilin YajC PF02699.15 ETO25706.1 - 1.6 8.7 4.7 0.38 10.7 0.9 1.9 2 0 0 2 2 2 0 Preprotein translocase subunit NPR3 PF03666.13 ETO25706.1 - 2.1 7.1 15.6 0.23 10.2 4.5 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ETO25706.1 - 5.1 6.8 9.7 0.15 11.8 1.9 2.1 2 0 0 2 2 2 0 Connexin Sec62 PF03839.16 ETO25706.1 - 9.2 5.7 18.8 0.018 14.5 4.2 2.6 3 0 0 3 3 3 0 Translocation protein Sec62 PIP5K PF01504.18 ETO25707.1 - 4.4e-10 39.2 0.4 4.4e-10 39.2 0.4 1.7 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase PriC PF07445.12 ETO25708.1 - 0.23 11.3 3.3 0.25 11.2 3.3 1.1 1 0 0 1 1 1 0 Primosomal replication protein priC 2OG-FeII_Oxy_5 PF13759.6 ETO25710.1 - 3.4e-17 62.7 0.0 9.4e-17 61.3 0.0 1.7 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase 2OG-FeII_Oxy_3 PF13640.6 ETO25710.1 - 0.0091 16.9 0.0 0.014 16.2 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily PCM1_C PF15717.5 ETO25711.1 - 0.22 10.2 21.8 0.24 10.1 21.8 1.0 1 0 0 1 1 1 0 Pericentriolar material 1 C terminus TFIIF_alpha PF05793.12 ETO25711.1 - 0.33 9.5 31.5 0.33 9.5 31.5 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Pox_Ag35 PF03286.14 ETO25711.1 - 3 7.6 21.4 3.6 7.3 21.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC27 PF09507.10 ETO25711.1 - 6.1 6.1 31.0 7.7 5.8 31.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Sec62 PF03839.16 ETO25711.1 - 6.4 6.2 20.7 7 6.1 20.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Vfa1 PF08432.10 ETO25711.1 - 7.1 6.9 28.3 8.5 6.7 28.3 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ADP_ribosyl_GH PF03747.14 ETO25712.1 - 1.9e-40 139.4 0.0 2.6e-40 139.0 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase CBM_5_12_2 PF14600.6 ETO25712.1 - 0.25 11.3 3.4 0.45 10.5 0.4 2.7 3 0 0 3 3 3 0 Cellulose-binding domain Renin_r PF07850.14 ETO25714.1 - 5.7 7.6 9.2 96 3.7 9.2 3.0 1 1 0 1 1 1 0 Renin receptor-like protein Trypan_PARP PF05887.11 ETO25715.1 - 0.0019 18.2 16.5 0.0019 18.2 16.5 2.2 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF4017 PF13209.6 ETO25715.1 - 1.4 8.9 4.2 0.28 11.1 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF4017) Vps26 PF03643.15 ETO25717.1 - 1.3e-37 129.4 7.0 1.3e-36 126.0 7.0 1.9 1 1 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_N PF00339.29 ETO25717.1 - 4.1e-10 39.9 0.4 8.1e-09 35.7 0.1 2.6 2 1 0 2 2 2 1 Arrestin (or S-antigen), N-terminal domain RTC PF01137.21 ETO25717.1 - 0.028 13.6 0.0 0.032 13.4 0.0 1.2 1 1 0 1 1 1 0 RNA 3'-terminal phosphate cyclase DUF5080 PF16883.5 ETO25717.1 - 0.031 14.4 2.1 0.056 13.6 2.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5080) COMM_domain PF07258.14 ETO25717.1 - 0.086 13.0 0.1 0.29 11.3 0.1 1.9 1 0 0 1 1 1 0 COMM domain MRNIP PF15749.5 ETO25717.1 - 0.12 13.1 0.3 0.28 11.9 0.3 1.6 1 0 0 1 1 1 0 MRN-interacting protein LPP PF04728.13 ETO25719.1 - 0.011 16.1 0.6 0.011 16.1 0.6 2.7 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DUF1515 PF07439.11 ETO25719.1 - 0.011 15.7 2.6 0.036 14.1 2.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) Fungal_TACC PF12709.7 ETO25719.1 - 0.023 15.1 2.7 0.023 15.1 2.7 3.9 1 1 3 4 4 4 0 Fungal Transforming acidic coiled-coil (TACC) proteins Med9 PF07544.13 ETO25719.1 - 0.37 10.9 11.8 0.54 10.4 8.6 2.5 1 1 1 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 BST2 PF16716.5 ETO25719.1 - 0.41 11.3 18.6 0.25 11.9 13.5 2.9 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 NPV_P10 PF05531.12 ETO25719.1 - 0.93 10.0 9.3 0.057 13.9 2.4 2.4 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Fzo_mitofusin PF04799.13 ETO25719.1 - 2.4 7.7 8.7 1.1 8.7 5.4 2.1 1 1 1 2 2 2 0 fzo-like conserved region GvpK PF05121.12 ETO25719.1 - 2.6 8.2 6.2 3.1 7.9 2.7 2.6 2 0 0 2 2 2 0 Gas vesicle protein K CENP-B_dimeris PF09026.10 ETO25719.1 - 2.7 8.4 10.6 3.5 8.1 2.3 3.0 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF1664 PF07889.12 ETO25719.1 - 3.7 7.6 8.1 1.9 8.5 3.9 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF2730 PF10805.8 ETO25719.1 - 5.6 7.1 10.7 2.1 8.5 4.5 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) HALZ PF02183.18 ETO25719.1 - 9.2 6.6 20.0 0.17 12.1 1.4 3.5 3 1 0 3 3 3 0 Homeobox associated leucine zipper ARID PF01388.21 ETO25720.1 - 1.8e-09 38.1 0.0 5.5e-09 36.6 0.0 1.9 1 0 0 1 1 1 1 ARID/BRIGHT DNA binding domain DUF3361 PF11841.8 ETO25720.1 - 0.046 13.7 1.1 0.5 10.3 0.2 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3361) Usher PF00577.20 ETO25720.1 - 0.17 10.7 0.7 0.26 10.1 0.1 1.5 2 0 0 2 2 2 0 Outer membrane usher protein DUF1981 PF09324.10 ETO25722.1 - 3.8e-27 93.9 1.6 3.8e-27 93.9 1.6 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF1981) Mon2_C PF16206.5 ETO25722.1 - 4.3e-05 21.9 1.2 0.0002 19.7 0.0 2.3 3 0 0 3 3 3 1 C-terminal region of Mon2 protein NARP1 PF12569.8 ETO25722.1 - 0.01 14.8 5.2 0.028 13.4 5.2 1.6 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 ETO25722.1 - 0.011 14.1 2.6 0.015 13.6 2.6 1.2 1 0 0 1 1 1 0 CDC45-like protein PRODH PF18327.1 ETO25722.1 - 0.022 15.0 0.0 0.097 12.9 0.0 2.1 1 0 0 1 1 1 0 Proline utilization A proline dehydrogenase N-terminal domain Peptidase_C37 PF05416.12 ETO25722.1 - 0.023 13.2 1.5 0.038 12.5 1.5 1.2 1 0 0 1 1 1 0 Southampton virus-type processing peptidase DUF4637 PF15470.6 ETO25722.1 - 0.1 12.3 10.2 0.013 15.2 5.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Zip PF02535.22 ETO25722.1 - 0.14 11.4 4.9 0.26 10.4 4.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO25722.1 - 0.91 8.2 7.4 2.5 6.8 7.4 1.7 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 ETO25722.1 - 1.2 9.2 6.6 3.3 7.8 6.6 1.7 1 0 0 1 1 1 0 Replication protein C C-terminal region Vfa1 PF08432.10 ETO25722.1 - 1.6 9.1 16.0 0.057 13.7 8.3 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO25722.1 - 1.9 8.2 6.8 1.3 8.7 4.5 1.9 2 0 0 2 2 2 0 Connexin CobT PF06213.12 ETO25722.1 - 2 7.7 17.7 3.6 6.9 17.7 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Orn_Arg_deC_N PF02784.16 ETO25723.1 - 0.072 12.4 1.6 0.1 11.9 1.6 1.2 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase, pyridoxal binding domain CDC37_N PF03234.14 ETO25723.1 - 5.1 8.0 11.3 1.1 10.2 6.0 2.0 1 1 1 2 2 2 0 Cdc37 N terminal kinase binding PI3K_1B_p101 PF10486.9 ETO25724.1 - 0.029 12.2 0.6 0.032 12.0 0.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Focal_AT PF03623.13 ETO25725.1 - 0.033 14.2 10.6 0.041 13.9 1.4 3.6 5 0 0 5 5 5 0 Focal adhesion targeting region Thiamine_BP PF01910.17 ETO25725.1 - 0.11 12.4 1.5 1.2 9.1 0.0 3.0 3 0 0 3 3 3 0 Thiamine-binding protein SSP160 PF06933.11 ETO25725.1 - 8.1 4.5 9.6 13 3.8 9.6 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSH1 PF03959.13 ETO25726.1 - 0.049 13.3 0.0 0.065 12.9 0.0 1.1 1 0 0 1 1 1 0 Serine hydrolase (FSH1) ASD2 PF08687.11 ETO25727.1 - 0.0064 16.1 4.3 0.0064 16.1 4.3 2.9 2 1 0 2 2 2 1 Apx/Shroom domain ASD2 FH2 PF02181.23 ETO25727.1 - 0.022 13.9 1.2 0.022 13.9 1.2 3.6 3 1 1 4 4 4 0 Formin Homology 2 Domain DUF641 PF04859.12 ETO25727.1 - 0.03 14.7 3.5 0.03 14.7 3.5 4.3 1 1 4 5 5 5 0 Plant protein of unknown function (DUF641) DegS PF05384.11 ETO25727.1 - 0.06 12.8 24.8 0.014 14.9 12.3 2.9 2 1 0 3 3 3 0 Sensor protein DegS EzrA PF06160.12 ETO25727.1 - 0.06 11.5 28.3 0.099 10.8 25.0 2.9 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA TolA_bind_tri PF16331.5 ETO25727.1 - 0.11 12.5 23.5 0.081 13.0 8.8 3.9 3 1 0 3 3 3 0 TolA binding protein trimerisation FAM184 PF15665.5 ETO25727.1 - 0.14 12.0 30.6 0.12 12.1 3.3 2.3 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Fez1 PF06818.15 ETO25727.1 - 0.26 11.7 40.1 0.056 13.9 25.1 2.9 1 1 1 2 2 2 0 Fez1 Lip_prot_lig_C PF10437.9 ETO25727.1 - 0.38 10.8 3.1 7.2 6.7 0.2 3.0 1 1 1 2 2 2 0 Bacterial lipoate protein ligase C-terminus Lebercilin PF15619.6 ETO25727.1 - 2.3 7.9 47.3 0.096 12.3 5.4 4.0 3 1 0 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease GPHR_N PF12537.8 ETO25727.1 - 3.1 8.0 0.0 3.1 8.0 0.0 3.4 3 1 1 4 4 4 0 The Golgi pH Regulator (GPHR) Family N-terminal ApoO PF09769.9 ETO25727.1 - 3.9 7.4 6.8 3.9 7.4 0.0 3.5 1 1 1 3 3 3 0 Apolipoprotein O A_deaminase PF00962.22 ETO25728.1 - 3.5e-97 325.7 0.0 2e-88 296.9 0.0 2.1 2 0 0 2 2 2 2 Adenosine/AMP deaminase FapA PF03961.13 ETO25729.1 - 0.11 11.0 13.0 0.16 10.5 13.0 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF5320 PF17253.2 ETO25729.1 - 0.18 12.9 0.2 0.18 12.9 0.2 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5320) XhlA PF10779.9 ETO25729.1 - 10 6.4 10.3 4.3 7.6 2.8 2.8 2 0 0 2 2 2 0 Haemolysin XhlA Phosducin PF02114.16 ETO25730.1 - 0.002 17.1 1.7 0.32 9.9 0.5 2.1 2 0 0 2 2 2 2 Phosducin DUF1464 PF07318.12 ETO25731.1 - 0.092 11.9 0.5 0.1 11.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1464) RR_TM4-6 PF06459.12 ETO25732.1 - 0.17 11.7 7.6 0.35 10.7 7.6 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 PBP1_TM PF14812.6 ETO25732.1 - 2.5 8.5 11.1 8.5 6.8 11.1 1.9 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 ETO25732.1 - 3 5.8 9.0 4.1 5.4 9.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Zip PF02535.22 ETO25732.1 - 6.8 5.8 5.2 11 5.1 5.2 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5523 PF17661.1 ETO25733.1 - 0.00043 20.0 12.3 0.00074 19.3 12.3 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5523) RNA_pol_Rpc4 PF05132.14 ETO25733.1 - 0.004 17.6 0.1 0.0079 16.6 0.1 1.5 1 0 0 1 1 1 1 RNA polymerase III RPC4 DUF4834 PF16118.5 ETO25733.1 - 0.0057 17.6 0.5 0.071 14.1 0.2 2.5 2 0 0 2 2 2 1 Domain of unknown function (DUF4834) Eapp_C PF10238.9 ETO25733.1 - 0.0059 16.7 0.6 0.015 15.4 0.6 1.7 1 0 0 1 1 1 1 E2F-associated phosphoprotein DUF2052 PF09747.9 ETO25733.1 - 0.0095 16.1 8.9 0.0095 16.1 8.9 1.6 2 0 0 2 2 1 1 Coiled-coil domain containing protein (DUF2052) SDA1 PF05285.12 ETO25733.1 - 0.011 15.2 11.0 0.017 14.5 11.0 1.2 1 0 0 1 1 1 0 SDA1 Anoctamin PF04547.12 ETO25733.1 - 0.021 13.7 0.8 0.1 11.4 0.3 1.9 2 0 0 2 2 2 0 Calcium-activated chloride channel PI3K_1B_p101 PF10486.9 ETO25733.1 - 0.024 12.4 2.3 0.033 12.0 2.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ORC_WH_C PF18137.1 ETO25733.1 - 0.031 14.4 10.9 0.068 13.2 10.9 1.5 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal NARP1 PF12569.8 ETO25733.1 - 0.033 13.1 8.1 0.051 12.5 8.1 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Connexin PF00029.19 ETO25733.1 - 0.033 14.0 3.5 0.073 12.8 3.5 1.6 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ETO25733.1 - 0.05 12.8 0.1 0.18 11.0 0.0 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter TraV PF09676.10 ETO25733.1 - 0.11 13.5 1.4 0.21 12.6 1.4 1.4 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) Nop14 PF04147.12 ETO25733.1 - 0.12 10.6 11.4 0.17 10.1 11.4 1.2 1 0 0 1 1 1 0 Nop14-like family DDHD PF02862.17 ETO25733.1 - 0.17 12.0 0.8 0.41 10.8 0.2 1.8 2 0 0 2 2 2 0 DDHD domain DUF913 PF06025.12 ETO25733.1 - 0.21 10.6 3.1 0.39 9.6 3.1 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CPSF100_C PF13299.6 ETO25733.1 - 0.23 11.6 7.7 0.049 13.8 4.3 1.5 2 0 0 2 2 1 0 Cleavage and polyadenylation factor 2 C-terminal DNA_pol_phi PF04931.13 ETO25733.1 - 0.23 9.5 18.3 0.35 8.9 18.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi HSP90 PF00183.18 ETO25733.1 - 0.31 9.9 14.4 0.52 9.1 14.4 1.3 1 0 0 1 1 1 0 Hsp90 protein Afi1 PF07792.12 ETO25733.1 - 0.33 11.4 6.6 0.26 11.8 4.7 1.8 2 0 0 2 2 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Presenilin PF01080.17 ETO25733.1 - 0.38 9.5 3.1 0.66 8.7 3.1 1.3 1 0 0 1 1 1 0 Presenilin V_ATPase_I PF01496.19 ETO25733.1 - 0.42 8.5 3.1 0.63 7.9 3.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ETO25733.1 - 0.51 8.6 10.3 0.83 7.9 10.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF853 PF05872.12 ETO25733.1 - 0.61 8.6 1.9 3.1 6.3 1.5 1.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF853) Ribosomal_L6e PF01159.19 ETO25733.1 - 0.76 10.3 4.9 2 9.0 4.9 1.6 1 0 0 1 1 1 0 Ribosomal protein L6e Borrelia_P83 PF05262.11 ETO25733.1 - 1.2 7.6 10.1 1.7 7.0 10.1 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Sec62 PF03839.16 ETO25733.1 - 1.5 8.3 4.4 2.8 7.4 4.4 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3464 PF11947.8 ETO25733.1 - 1.9 8.3 5.4 3.8 7.2 5.4 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Tim54 PF11711.8 ETO25733.1 - 2 7.1 9.5 3.7 6.2 9.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RR_TM4-6 PF06459.12 ETO25733.1 - 2.8 7.7 13.3 5.1 6.8 13.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 ETO25733.1 - 2.8 7.7 15.4 5.2 6.8 15.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein MscS_TM PF12794.7 ETO25733.1 - 3 6.6 6.5 7 5.4 6.5 1.5 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DNA_pol3_a_NII PF11490.8 ETO25733.1 - 4.4 7.2 20.5 5.9 6.8 18.4 2.2 2 0 0 2 2 2 0 DNA polymerase III polC-type N-terminus II Paf1 PF03985.13 ETO25733.1 - 6.4 5.7 19.8 9.8 5.1 19.8 1.2 1 0 0 1 1 1 0 Paf1 TRAP_alpha PF03896.16 ETO25733.1 - 7.7 5.6 9.9 13 4.9 9.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 ETO25733.1 - 9.1 6.2 17.7 17 5.3 17.7 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain WD40 PF00400.32 ETO25734.1 - 6e-40 134.5 26.8 2.3e-07 31.4 0.6 7.9 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25734.1 - 2.2e-10 40.7 2.1 1.7 9.0 0.0 5.8 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO25734.1 - 1.3e-08 34.0 5.6 0.7 8.5 0.0 5.5 2 2 4 6 6 6 5 Nucleoporin Nup120/160 Caldesmon PF02029.15 ETO25735.1 - 0.00073 18.4 15.6 0.00099 18.0 15.6 1.1 1 0 0 1 1 1 1 Caldesmon Orf78 PF06024.12 ETO25735.1 - 0.0017 18.6 0.2 0.0017 18.6 0.2 3.2 1 1 2 3 3 3 1 Orf78 (ac78) LMBR1 PF04791.16 ETO25735.1 - 0.0052 15.8 1.0 0.0084 15.1 1.0 1.2 1 0 0 1 1 1 1 LMBR1-like membrane protein CrgA PF06781.12 ETO25735.1 - 1.1 9.4 0.0 1.1 9.4 0.0 3.2 3 2 0 3 3 3 0 Cell division protein CrgA THOC2_N PF16134.5 ETO25735.1 - 1.4 7.5 12.2 0.014 14.0 4.5 1.6 2 0 0 2 2 2 0 THO complex subunit 2 N-terminus Shisa PF13908.6 ETO25735.1 - 3.4 7.9 10.5 0.11 12.8 2.8 1.9 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator UPF0564 PF10595.9 ETO25735.1 - 4.4 6.3 29.2 0.036 13.1 20.1 1.8 2 0 0 2 2 2 0 Uncharacterised protein family UPF0564 zf-TRAF PF02176.18 ETO25736.1 - 3.9e-06 27.5 4.6 4.3e-06 27.3 3.3 1.8 1 1 0 1 1 1 1 TRAF-type zinc finger Sina PF03145.16 ETO25736.1 - 0.0015 18.5 4.1 0.0028 17.6 4.1 1.4 1 0 0 1 1 1 1 Seven in absentia protein family DUF4600 PF15372.6 ETO25737.1 - 0.0035 17.8 4.3 0.43 11.0 2.2 2.3 1 1 1 2 2 2 2 Domain of unknown function (DUF4600) Holin_BhlA PF10960.8 ETO25737.1 - 0.052 13.5 5.8 2.4 8.2 0.2 3.2 2 2 0 2 2 2 0 BhlA holin family Muted PF14942.6 ETO25737.1 - 0.057 13.8 7.3 0.095 13.0 7.3 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein ALMT PF11744.8 ETO25737.1 - 0.17 10.7 5.9 0.25 10.1 5.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter Enkurin PF13864.6 ETO25737.1 - 0.27 11.7 8.4 0.88 10.1 7.4 2.3 2 1 0 2 2 2 0 Calmodulin-binding GrpE PF01025.19 ETO25737.1 - 0.29 10.8 6.3 0.48 10.1 6.3 1.4 1 0 0 1 1 1 0 GrpE NPBW PF15180.6 ETO25737.1 - 0.3 11.0 2.0 1.5 8.7 0.1 2.4 3 0 0 3 3 3 0 Neuropeptides B and W HECT PF00632.25 ETO25738.1 - 6.5e-38 131.0 0.6 1.5e-37 129.8 0.2 1.7 2 0 0 2 2 2 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ETO25738.1 - 1.8e-13 50.7 0.1 7.5e-13 48.6 0.1 2.1 1 1 0 1 1 1 1 SPRY domain BUD22 PF09073.10 ETO25738.1 - 0.00031 20.2 0.6 0.00031 20.2 0.6 6.5 5 2 1 6 6 6 1 BUD22 UIM PF02809.20 ETO25738.1 - 0.038 13.9 0.4 0.11 12.4 0.4 1.9 1 0 0 1 1 1 0 Ubiquitin interaction motif DUF5470 PF17564.2 ETO25738.1 - 1 9.6 9.8 4.2 7.6 9.8 2.1 1 0 0 1 1 1 0 Family of unknown function (DUF5470) DUF2852 PF11014.8 ETO25738.1 - 1.4 9.1 0.0 1.4 9.1 0.0 4.5 4 0 0 4 4 4 0 Protein of unknown function (DUF2852) WD40 PF00400.32 ETO25739.1 - 3.6e-36 122.6 32.4 4.8e-06 27.2 2.0 8.3 7 4 0 7 7 7 7 WD domain, G-beta repeat Nup160 PF11715.8 ETO25739.1 - 1.5e-12 46.9 0.9 0.21 10.2 0.1 5.9 1 1 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO25739.1 - 2.6e-10 40.5 1.0 0.32 11.3 0.0 6.0 4 1 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO25739.1 - 2.4e-07 30.4 8.4 0.26 10.6 0.0 5.0 1 1 2 5 5 5 3 WD40-like domain DUF1541 PF07563.11 ETO25739.1 - 0.015 15.2 0.2 6.6 6.7 0.0 4.4 5 0 0 5 5 5 0 Protein of unknown function (DUF1541) DUF4221 PF13970.6 ETO25739.1 - 0.08 12.5 7.9 0.33 10.5 1.1 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4221) Bcl-2_3 PF15286.6 ETO25739.1 - 0.26 12.0 2.2 4.8 7.9 0.2 3.0 2 1 1 3 3 3 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like Mis12 PF05859.12 ETO25740.1 - 4.7e-06 26.7 3.3 4.7e-06 26.7 3.3 2.1 2 1 0 2 2 2 1 Mis12 protein LpxI_N PF17930.1 ETO25740.1 - 0.029 14.2 0.3 0.073 13.0 0.1 1.8 2 0 0 2 2 2 0 LpxI N-terminal domain UPF0242 PF06785.11 ETO25740.1 - 0.11 12.5 11.7 0.11 12.7 9.4 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus EMP24_GP25L PF01105.24 ETO25740.1 - 0.41 10.5 7.7 0.092 12.7 3.3 2.1 1 1 1 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF2203 PF09969.9 ETO25740.1 - 1.1 10.0 7.1 1.1 9.9 0.4 2.8 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) V_ATPase_I PF01496.19 ETO25740.1 - 3.3 5.5 11.2 0.98 7.3 7.4 1.8 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family Halogen_Hydrol PF10112.9 ETO25740.1 - 4.3 7.3 7.4 14 5.6 0.4 2.5 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein APG5 PF04106.12 ETO25740.1 - 5.2 6.6 7.8 4.5 6.8 6.0 1.8 1 1 1 2 2 2 0 Autophagy protein Apg5 APG6_N PF17675.1 ETO25740.1 - 5.2 7.6 18.5 3.4 8.2 14.3 2.5 2 1 1 3 3 3 0 Apg6 coiled-coil region Secretin_N_2 PF07655.13 ETO25741.1 - 0.0017 18.9 19.6 0.0038 17.7 19.6 1.6 1 0 0 1 1 1 1 Secretin N-terminal domain AAR2 PF05282.11 ETO25741.1 - 0.023 14.1 7.1 0.032 13.7 7.1 1.1 1 0 0 1 1 1 0 AAR2 protein WD40 PF00400.32 ETO25741.1 - 0.13 13.2 0.4 0.56 11.2 0.0 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat Menin PF05053.13 ETO25741.1 - 0.79 8.0 9.5 0.98 7.7 9.5 1.1 1 0 0 1 1 1 0 Menin CSG2 PF16965.5 ETO25741.1 - 2.3 7.1 5.3 3.1 6.7 5.3 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Pal1 PF08316.11 ETO25741.1 - 2.5 8.8 10.0 3.8 8.3 10.0 1.3 1 0 0 1 1 1 0 Pal1 cell morphology protein NST1 PF13945.6 ETO25741.1 - 2.8 8.0 21.1 4.1 7.5 21.1 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Presenilin PF01080.17 ETO25741.1 - 3.2 6.4 6.5 3.5 6.3 6.5 1.1 1 0 0 1 1 1 0 Presenilin DUF3245 PF11595.8 ETO25742.1 - 0.052 14.0 9.9 0.12 12.9 9.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) Cwf_Cwc_15 PF04889.12 ETO25742.1 - 2.1 8.0 17.1 3.7 7.2 17.1 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.32 ETO25743.1 - 2.8e-11 43.8 12.3 1.7e-05 25.5 0.3 3.7 3 1 0 3 3 3 3 WD domain, G-beta repeat Presenilin PF01080.17 ETO25745.1 - 0.33 9.7 6.8 0.55 8.9 6.8 1.2 1 0 0 1 1 1 0 Presenilin YMF19 PF02326.15 ETO25745.1 - 0.57 11.0 3.0 0.41 11.5 0.2 2.2 2 0 0 2 2 2 0 Plant ATP synthase F0 MraZ PF02381.18 ETO25746.1 - 0.065 13.2 0.1 4.9 7.2 0.0 2.5 2 0 0 2 2 2 0 MraZ protein, putative antitoxin-like Tymo_45kd_70kd PF03251.13 ETO25746.1 - 0.13 11.1 0.0 0.18 10.7 0.0 1.1 1 0 0 1 1 1 0 Tymovirus 45/70Kd protein C2 PF00168.30 ETO25747.1 - 6e-06 26.5 0.3 2e-05 24.8 0.3 1.9 1 0 0 1 1 1 1 C2 domain Dynamin_M PF01031.20 ETO25748.1 - 6.5e-30 104.3 4.4 1.3e-29 103.4 4.4 1.5 1 0 0 1 1 1 1 Dynamin central region Dynamin_N PF00350.23 ETO25748.1 - 7e-27 94.5 0.2 2.6e-26 92.7 0.2 2.1 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ETO25748.1 - 6.4e-06 26.2 8.3 1.1e-05 25.5 1.9 3.6 2 1 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ETO25748.1 - 0.0017 18.5 0.1 0.013 15.6 0.0 2.6 2 1 0 2 2 2 1 50S ribosome-binding GTPase AAA_29 PF13555.6 ETO25748.1 - 0.055 13.2 0.2 0.14 11.9 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_15 PF13175.6 ETO25748.1 - 0.085 12.6 12.1 3.4e+02 0.7 12.1 2.9 1 1 0 1 1 1 0 AAA ATPase domain rhaM PF05336.13 ETO25749.1 - 9.2e-33 112.5 0.1 1.1e-32 112.3 0.1 1.1 1 0 0 1 1 1 1 L-rhamnose mutarotase Coiled-coil_56 PF09813.9 ETO25749.1 - 0.01 15.8 0.0 0.013 15.5 0.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 PDR_CDR PF06422.12 ETO25751.1 - 0.014 15.2 0.2 0.027 14.3 0.2 1.4 1 0 0 1 1 1 0 CDR ABC transporter POTRA_2 PF08479.11 ETO25751.1 - 0.44 10.4 5.2 0.63 9.9 0.4 2.8 3 0 0 3 3 3 0 POTRA domain, ShlB-type Spy1 PF11357.8 ETO25751.1 - 0.65 10.3 8.3 1.4 9.2 8.3 1.6 1 1 0 1 1 1 0 Cell cycle regulatory protein RuvC_1 PF18516.1 ETO25751.1 - 1.3 8.1 13.5 0.033 13.4 6.7 1.7 2 0 0 2 2 2 0 RuvC nuclease domain SIMPL PF04402.14 ETO25751.1 - 1.7 9.1 6.7 5.8 7.3 0.8 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF541) Fib_alpha PF08702.10 ETO25751.1 - 6.8 6.9 30.7 9.5 6.4 15.2 2.4 2 1 0 2 2 2 0 Fibrinogen alpha/beta chain family RhoGEF PF00621.20 ETO25753.1 - 9.4e-05 22.7 3.9 9.4e-05 22.7 3.9 2.6 1 1 1 2 2 2 1 RhoGEF domain Adeno_VII PF03228.14 ETO25753.1 - 0.93 10.1 5.1 1.5 9.5 5.1 1.5 1 1 0 1 1 1 0 Adenoviral core protein VII Bindin PF02084.15 ETO25755.1 - 0.048 13.9 0.9 0.048 13.9 0.9 1.5 2 0 0 2 2 2 0 Bindin Pkinase PF00069.25 ETO25756.1 - 1.8e-08 34.1 0.9 2.4e-08 33.7 0.9 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25756.1 - 0.0036 16.6 0.3 0.0051 16.1 0.3 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO25757.1 - 1.6e-55 188.3 0.0 2.3e-55 187.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25757.1 - 4.3e-25 88.5 0.0 5.5e-25 88.1 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO25757.1 - 4.8e-05 22.8 0.0 6.2e-05 22.5 0.0 1.2 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO25757.1 - 9.6e-05 22.4 0.0 0.00018 21.5 0.0 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO25757.1 - 9.8e-05 21.3 0.0 0.00014 20.8 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO25757.1 - 0.0005 19.5 0.0 0.00082 18.8 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family PBP1_TM PF14812.6 ETO25759.1 - 0.056 13.8 0.4 0.18 12.2 0.1 2.1 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-C2H2_6 PF13912.6 ETO25759.1 - 0.066 13.2 1.0 0.14 12.2 1.0 1.5 1 0 0 1 1 1 0 C2H2-type zinc finger FYVE PF01363.21 ETO25759.1 - 0.13 12.4 4.2 0.24 11.5 4.2 1.6 1 1 0 1 1 1 0 FYVE zinc finger Virulence_fact PF13769.6 ETO25761.1 - 0.0027 17.9 0.7 0.12 12.6 0.1 2.7 1 1 1 2 2 2 1 Virulence factor Pyrophosphatase PF00719.19 ETO25761.1 - 0.051 13.4 0.6 0.051 13.4 0.6 1.6 2 0 0 2 2 2 0 Inorganic pyrophosphatase IBB PF01749.20 ETO25761.1 - 0.26 11.8 9.2 0.33 11.4 1.5 2.8 3 0 0 3 3 3 0 Importin beta binding domain Ima1_N PF09779.9 ETO25761.1 - 2.1 9.2 6.6 1.3 9.8 3.9 2.0 2 2 0 2 2 2 0 Ima1 N-terminal domain KxDL PF10241.9 ETO25761.1 - 2.2 8.6 8.1 3 8.2 4.4 2.9 2 2 0 2 2 2 0 Uncharacterized conserved protein WD40 PF00400.32 ETO25763.1 - 1.4e-45 152.3 19.2 2.8e-09 37.4 0.6 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25763.1 - 1.6e-12 47.5 0.8 0.17 12.2 0.0 5.8 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO25763.1 - 2.9e-11 42.7 7.4 0.0029 16.3 0.1 5.4 2 2 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO25763.1 - 0.00043 19.7 5.5 0.17 11.2 0.3 4.1 2 2 2 4 4 4 2 WD40-like domain DUF2606 PF10794.9 ETO25763.1 - 0.095 12.5 0.0 0.78 9.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2606) DMT_YdcZ PF04657.13 ETO25764.1 - 6.1e-36 123.8 22.4 6.2e-20 71.9 8.0 3.3 3 0 0 3 3 3 3 Putative inner membrane exporter, YdcZ Mak10 PF04112.13 ETO25764.1 - 0.01 15.4 0.3 0.064 12.8 0.1 2.1 2 0 0 2 2 2 0 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Acyl-CoA_dh_1 PF00441.24 ETO25765.1 - 1.3e-38 132.5 0.0 1.6e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO25765.1 - 2e-19 70.2 0.0 2.3e-19 70.0 0.0 1.1 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETO25766.1 - 4.4e-27 95.0 0.0 1.6e-26 93.2 0.0 1.8 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETO25766.1 - 1.3e-24 86.2 0.0 2.3e-24 85.4 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain HpaB_N PF11794.8 ETO25766.1 - 0.024 14.3 0.0 0.033 13.8 0.0 1.3 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Helicase_C PF00271.31 ETO25767.1 - 1.5e-12 47.8 0.1 7.2e-12 45.6 0.1 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain zf-C3HC4_2 PF13923.6 ETO25767.1 - 0.0057 16.5 6.4 0.0057 16.5 6.4 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-Nse PF11789.8 ETO25767.1 - 1.5 8.7 5.0 0.55 10.1 0.9 2.4 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_3 PF13920.6 ETO25767.1 - 1.8 8.5 13.3 0.12 12.2 5.2 2.6 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO25767.1 - 3.6 7.7 14.6 0.058 13.4 5.9 2.5 2 0 0 2 2 2 0 RING-type zinc-finger zf-RING_2 PF13639.6 ETO25767.1 - 3.6 8.0 14.4 0.32 11.4 4.8 3.1 2 0 0 2 2 2 0 Ring finger domain SNF2_N PF00176.23 ETO25768.1 - 2e-58 197.8 1.5 3.1e-51 174.2 0.0 3.2 3 0 0 3 3 3 2 SNF2 family N-terminal domain DivIC PF04977.15 ETO25769.1 - 0.0012 18.5 0.4 0.0012 18.5 0.4 3.9 2 1 1 4 4 4 1 Septum formation initiator Prp19 PF08606.11 ETO25769.1 - 0.052 13.5 13.4 0.12 12.4 0.8 3.2 3 0 0 3 3 3 0 Prp19/Pso4-like MtrG PF04210.13 ETO25769.1 - 0.41 10.5 3.3 13 5.7 0.1 2.8 3 0 0 3 3 3 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF4407 PF14362.6 ETO25769.1 - 0.97 8.7 18.8 2.3 7.5 11.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TSC22 PF01166.18 ETO25769.1 - 4.2 7.8 12.9 13 6.2 1.8 3.4 2 1 0 2 2 2 0 TSC-22/dip/bun family DUF1664 PF07889.12 ETO25769.1 - 6.3 6.9 18.0 7.4 6.6 1.9 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) Rap_GAP PF02145.15 ETO25770.1 - 6.8e-44 149.6 0.5 1.5e-43 148.6 0.5 1.5 1 0 0 1 1 1 1 Rap/ran-GAP GWT1 PF06423.12 ETO25770.1 - 0.018 15.1 0.5 0.098 12.8 0.5 2.4 1 0 0 1 1 1 0 GWT1 Xpo1 PF08389.12 ETO25770.1 - 0.042 13.9 0.2 1.5 8.9 0.0 3.2 2 1 1 3 3 3 0 Exportin 1-like protein MANEC PF07502.14 ETO25771.1 - 0.32 11.3 3.0 0.36 11.1 1.7 1.6 1 1 0 1 1 1 0 MANEC domain ARF7EP_C PF14949.6 ETO25772.1 - 0.0052 17.4 0.6 0.01 16.4 0.6 1.4 1 0 0 1 1 1 1 ARF7 effector protein C-terminus AAA_15 PF13175.6 ETO25772.1 - 0.014 15.1 6.4 0.017 14.9 6.4 1.1 1 0 0 1 1 1 0 AAA ATPase domain Adipogenin PF15202.6 ETO25772.1 - 0.13 12.3 0.3 0.48 10.5 0.2 1.9 2 0 0 2 2 2 0 Adipogenin DUF2545 PF10810.8 ETO25774.1 - 0.0051 16.9 0.2 0.0097 16.0 0.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF2545) DUF678 PF05077.12 ETO25774.1 - 0.18 12.0 1.0 0.27 11.4 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF678) G-alpha PF00503.20 ETO25775.1 - 2.7e-80 270.2 3.9 7.9e-50 170.0 0.1 2.0 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO25775.1 - 6.8e-09 35.4 0.3 0.00037 20.0 0.0 3.2 3 0 0 3 3 3 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO25775.1 - 0.0019 18.2 0.0 0.13 12.3 0.0 2.9 1 1 0 1 1 1 1 50S ribosome-binding GTPase Roc PF08477.13 ETO25775.1 - 0.015 15.5 0.0 0.18 12.1 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 ETO25775.1 - 0.019 14.4 0.0 0.041 13.3 0.0 1.6 1 1 0 1 1 1 0 Bacterial TniB protein SRPRB PF09439.10 ETO25775.1 - 0.1 12.0 0.1 1.1 8.6 0.0 2.5 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit RIO1 PF01163.22 ETO25775.1 - 0.14 11.7 0.0 0.26 10.9 0.0 1.3 1 0 0 1 1 1 0 RIO1 family Bromodomain PF00439.25 ETO25776.1 - 1e-17 63.9 2.7 1.7e-17 63.2 2.7 1.4 1 0 0 1 1 1 1 Bromodomain EF-hand_7 PF13499.6 ETO25777.1 - 7.7e-11 42.3 7.0 3.6e-09 37.0 0.9 1.9 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO25777.1 - 6.3e-08 31.6 4.2 4.5e-05 22.7 0.2 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO25777.1 - 2.7e-07 30.0 4.3 0.0095 15.8 0.6 2.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO25777.1 - 3.2e-07 29.6 0.7 1.9e-06 27.1 0.1 2.3 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO25777.1 - 1.7e-05 24.6 1.9 0.0011 18.8 0.0 2.2 2 0 0 2 2 2 2 EF-hand domain pair WD40 PF00400.32 ETO25778.1 - 2.1e-50 167.6 20.6 2.4e-11 44.0 0.4 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25778.1 - 2.1e-20 72.8 1.3 0.00016 21.9 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25778.1 - 8.3e-14 51.3 2.7 0.007 15.4 0.0 5.6 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO25778.1 - 4e-08 32.9 1.0 0.0015 17.9 0.0 3.7 1 1 2 3 3 3 3 WD40-like domain Nbas_N PF15492.6 ETO25778.1 - 4.5e-06 26.2 1.8 1.1 8.6 0.0 4.1 1 1 2 4 4 4 3 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO25778.1 - 7.2e-06 24.9 8.2 0.33 9.5 1.1 5.0 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO25778.1 - 0.00014 20.8 6.6 0.08 11.7 0.2 4.1 1 1 2 4 4 4 2 Nup133 N terminal like DUF285 PF03382.14 ETO25778.1 - 0.00033 20.4 0.4 0.16 11.7 0.3 2.9 2 1 0 2 2 2 2 Mycoplasma protein of unknown function, DUF285 PD40 PF07676.12 ETO25778.1 - 0.00043 20.1 1.3 1.2 9.2 0.1 3.7 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO25778.1 - 0.00059 18.5 4.0 0.0083 14.7 0.2 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain HARP PF07443.13 ETO25778.1 - 0.022 14.4 0.1 18 5.1 0.0 3.8 4 0 0 4 4 4 0 HepA-related protein (HARP) Utp8 PF10395.9 ETO25778.1 - 0.028 13.0 0.5 0.29 9.6 0.0 2.3 1 1 1 2 2 2 0 Utp8 family Arena_nucleocap PF00843.17 ETO25778.1 - 0.028 13.3 1.1 2 7.2 0.0 3.2 2 2 1 3 3 3 0 Arenavirus nucleocapsid N-terminal domain DUF719 PF05334.13 ETO25779.1 - 0.063 13.5 2.6 0.15 12.3 2.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF719) TFB6 PF17110.5 ETO25779.1 - 0.22 11.3 2.3 0.46 10.2 2.3 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH NOA36 PF06524.12 ETO25779.1 - 0.29 10.4 8.1 0.17 11.1 5.8 1.7 2 0 0 2 2 2 0 NOA36 protein Pex24p PF06398.11 ETO25780.1 - 0.25 10.3 2.3 0.2 10.6 0.7 1.5 1 1 0 1 1 1 0 Integral peroxisomal membrane peroxin Asp PF00026.23 ETO25781.1 - 5.4e-29 101.6 6.4 5.9e-20 71.9 2.6 2.9 2 1 0 2 2 2 2 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO25781.1 - 7.1e-08 32.9 4.2 4.3e-06 27.1 1.2 3.1 2 1 0 2 2 2 1 Xylanase inhibitor N-terminal RR_TM4-6 PF06459.12 ETO25782.1 - 0.0089 15.9 1.3 0.051 13.4 0.3 2.4 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 Bee_toxin PF17454.2 ETO25783.1 - 0.25 11.4 1.3 0.34 11.0 0.0 1.9 2 0 0 2 2 2 0 Honey bee toxin NDUFB11 PF17250.2 ETO25784.1 - 0.15 12.7 0.1 0.15 12.7 0.1 2.9 3 1 0 3 3 3 0 NADH-ubiquinone oxidoreductase 11 kDa subunit Cation_efflux PF01545.21 ETO25785.1 - 1.2e-17 64.3 2.6 1.9e-15 57.2 0.0 2.1 2 0 0 2 2 2 2 Cation efflux family Cnd1_N PF12922.7 ETO25785.1 - 0.0031 17.4 0.1 0.0058 16.5 0.1 1.5 1 0 0 1 1 1 1 non-SMC mitotic condensation complex subunit 1, N-term ERCC4 PF02732.15 ETO25785.1 - 0.026 14.7 0.1 0.043 14.0 0.1 1.7 1 1 0 1 1 1 0 ERCC4 domain ETRAMP PF09716.10 ETO25785.1 - 0.097 12.7 14.5 0.17 12.0 7.0 3.2 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Glycophorin_A PF01102.18 ETO25785.1 - 0.18 12.0 0.1 0.42 10.9 0.0 1.6 2 0 0 2 2 2 0 Glycophorin A HELP PF03451.14 ETO25785.1 - 0.35 10.7 1.6 6.8 6.6 0.0 3.2 3 1 1 4 4 4 0 HELP motif DUF4710 PF15828.5 ETO25785.1 - 0.52 10.5 10.7 1.3 9.2 7.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) YqzE PF14038.6 ETO25785.1 - 3.8 7.6 9.5 6.5 6.8 5.6 2.2 2 0 0 2 2 2 0 YqzE-like protein Kelch_6 PF13964.6 ETO25786.1 - 2.2e-08 34.1 0.1 0.0026 18.0 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO25786.1 - 6.1e-08 32.1 0.5 4.8e-05 22.8 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO25786.1 - 1.6e-05 24.8 0.9 5.4e-05 23.1 0.0 2.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO25786.1 - 0.00045 20.1 4.7 0.0049 16.8 0.2 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO25786.1 - 0.0012 19.1 0.0 0.0056 16.9 0.0 2.1 3 0 0 3 3 3 1 Galactose oxidase, central domain F-box PF00646.33 ETO25787.1 - 0.00062 19.6 0.5 0.0028 17.5 0.2 2.1 2 0 0 2 2 2 1 F-box domain Folate_carrier PF01770.18 ETO25788.1 - 0.12 11.1 2.2 0.21 10.3 2.2 1.4 1 0 0 1 1 1 0 Reduced folate carrier PH PF00169.29 ETO25789.1 - 1.6e-15 57.5 1.1 2.7e-15 56.7 1.1 1.4 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO25789.1 - 7.5e-09 35.7 0.4 1.2e-08 35.1 0.4 1.3 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ETO25789.1 - 2.6e-08 33.9 0.7 4.4e-08 33.2 0.7 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO25789.1 - 0.00036 20.9 9.9 0.0017 18.8 4.9 2.7 2 1 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 ETO25789.1 - 0.0012 19.1 0.6 0.0046 17.3 0.6 2.0 1 1 0 1 1 1 1 Plant pleckstrin homology-like region PH_6 PF15406.6 ETO25789.1 - 0.0086 16.4 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_12 PF16457.5 ETO25789.1 - 2.5 8.6 7.1 0.95 10.0 0.3 2.8 2 1 1 3 3 3 0 Pleckstrin homology domain Flavodoxin_1 PF00258.25 ETO25790.1 - 3.5e-39 134.3 0.4 7.3e-39 133.2 0.4 1.6 1 0 0 1 1 1 1 Flavodoxin FAD_binding_1 PF00667.20 ETO25790.1 - 3.1e-37 128.3 0.1 8.9e-37 126.8 0.0 1.8 2 0 0 2 2 2 1 FAD binding domain NAD_binding_1 PF00175.21 ETO25790.1 - 4.8e-12 46.5 0.0 1.6e-11 44.8 0.0 2.0 1 0 0 1 1 1 1 Oxidoreductase NAD-binding domain DUF4279 PF14106.6 ETO25790.1 - 0.062 13.5 0.0 3.1 8.0 0.0 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4279) Phage_Gp23 PF10669.9 ETO25790.1 - 0.089 13.1 0.1 0.089 13.1 0.1 2.0 3 0 0 3 3 3 0 Protein gp23 (Bacteriophage A118) DUF4464 PF14713.6 ETO25791.1 - 0.14 11.7 0.6 0.26 10.8 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4464) NPR3 PF03666.13 ETO25793.1 - 6.8e-14 51.5 1.4 6.8e-14 51.5 1.4 1.9 2 0 0 2 2 2 1 Nitrogen Permease regulator of amino acid transport activity 3 Paf1 PF03985.13 ETO25794.1 - 6.3 5.7 21.4 6.3 5.7 21.4 1.1 1 0 0 1 1 1 0 Paf1 Pkinase_Tyr PF07714.17 ETO25795.1 - 1e-12 48.0 0.0 1.5e-12 47.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO25795.1 - 5.7e-12 45.6 0.0 1e-11 44.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain CNDH2_M PF16869.5 ETO25795.1 - 0.11 13.2 1.1 0.18 12.5 1.1 1.3 1 0 0 1 1 1 0 PF16858 DUF2723 PF11028.8 ETO25795.1 - 0.42 10.5 5.9 0.82 9.6 5.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2723) Afi1 PF07792.12 ETO25795.1 - 0.8 10.2 3.8 1.6 9.2 3.8 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RR_TM4-6 PF06459.12 ETO25795.1 - 7.8 6.2 10.6 13 5.5 10.6 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LicD PF04991.13 ETO25796.1 - 1.7 8.7 8.1 2.3 8.3 8.1 1.2 1 0 0 1 1 1 0 LicD family Neur_chan_memb PF02932.16 ETO25796.1 - 3.6 7.6 7.5 4.3 7.3 7.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 ETO25796.1 - 3.6 6.3 13.4 4.5 5.9 13.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3438 PF11920.8 ETO25796.1 - 3.9 6.6 14.0 0.029 13.6 4.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3438) SID-1_RNA_chan PF13965.6 ETO25796.1 - 7.6 4.8 7.1 8.8 4.6 7.1 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 AAA_11 PF13086.6 ETO25796.1 - 8.7 6.0 19.0 10 5.8 19.0 1.0 1 0 0 1 1 1 0 AAA domain PspB PF06667.12 ETO25797.1 - 0.016 15.3 3.2 0.63 10.1 0.0 4.0 4 0 0 4 4 4 0 Phage shock protein B DUF4834 PF16118.5 ETO25798.1 - 0.0002 22.3 0.0 0.00042 21.2 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) DUF929 PF06053.11 ETO25798.1 - 0.087 12.1 0.5 0.11 11.8 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF929) CENP-B_dimeris PF09026.10 ETO25798.1 - 0.29 11.5 3.9 0.48 10.9 3.9 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CDC27 PF09507.10 ETO25800.1 - 0.14 11.5 18.7 0.19 11.1 18.7 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SPOUT_MTase PF02590.17 ETO25800.1 - 2.6 8.0 7.1 4.4 7.3 6.8 1.5 1 1 0 1 1 1 0 Predicted SPOUT methyltransferase Na_Ca_ex PF01699.24 ETO25801.1 - 7.8e-05 22.7 0.3 7.8e-05 22.7 0.3 1.9 2 1 1 3 3 3 1 Sodium/calcium exchanger protein EF-hand_5 PF13202.6 ETO25802.1 - 3.7e-08 32.5 3.1 7.1e-08 31.6 1.2 2.4 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO25802.1 - 3.7e-08 32.7 2.8 9.6e-08 31.4 0.5 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_7 PF13499.6 ETO25802.1 - 8.8e-08 32.5 2.8 8.8e-08 32.5 2.8 2.2 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO25802.1 - 1.2e-07 30.7 0.6 1.2e-07 30.7 0.6 3.0 3 1 0 3 3 3 1 EF hand Neur_chan_memb PF02932.16 ETO25802.1 - 0.095 12.7 4.9 0.12 12.4 4.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region EF-hand_8 PF13833.6 ETO25802.1 - 0.11 12.4 0.2 0.11 12.4 0.2 2.8 2 1 1 3 3 3 0 EF-hand domain pair Caleosin PF05042.13 ETO25802.1 - 0.18 11.7 0.1 0.18 11.7 0.1 1.9 2 1 0 2 2 2 0 Caleosin related protein Zn_ribbon_2 PF12674.7 ETO25802.1 - 0.36 11.5 9.1 0.14 12.8 5.8 2.0 2 0 0 2 2 2 0 Putative zinc ribbon domain Zip PF02535.22 ETO25802.1 - 0.5 9.5 5.5 0.7 9.1 5.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter MscS_TM PF12794.7 ETO25802.1 - 0.61 8.9 2.6 1.3 7.9 2.6 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 IL3Ra_N PF18611.1 ETO25802.1 - 0.77 9.8 5.4 0.89 9.6 4.0 1.8 1 1 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain Sec5 PF15469.6 ETO25803.1 - 0.0035 17.2 5.0 0.0047 16.8 5.0 1.2 1 0 0 1 1 1 1 Exocyst complex component Sec5 Sporozoite_P67 PF05642.11 ETO25803.1 - 0.61 8.1 15.2 0.19 9.8 11.6 1.7 1 1 1 2 2 2 0 Sporozoite P67 surface antigen IL1_propep PF02394.16 ETO25803.1 - 5.7 7.9 7.7 14 6.6 7.7 2.0 1 1 0 1 1 1 0 Interleukin-1 propeptide ECH_2 PF16113.5 ETO25804.1 - 2.1e-113 379.2 0.0 2.6e-113 378.9 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_1 PF00378.20 ETO25804.1 - 7.9e-26 90.9 0.1 1.9e-24 86.4 0.0 2.4 2 1 0 2 2 2 1 Enoyl-CoA hydratase/isomerase OTU PF02338.19 ETO25805.1 - 2.1e-17 63.8 0.1 2.1e-17 63.8 0.1 2.9 3 1 0 3 3 3 1 OTU-like cysteine protease SEC-C PF02810.15 ETO25805.1 - 0.00014 21.7 15.1 0.00033 20.5 15.1 1.6 1 0 0 1 1 1 1 SEC-C motif Rootletin PF15035.6 ETO25806.1 - 0.0025 17.9 15.6 0.0025 17.9 15.6 2.3 2 0 0 2 2 2 1 Ciliary rootlet component, centrosome cohesion DUF2483 PF10656.9 ETO25806.1 - 0.11 12.7 1.1 0.49 10.6 0.0 2.4 3 0 0 3 3 3 0 Hypothetical protein of unknown function (DUF2483) TPR_MLP1_2 PF07926.12 ETO25806.1 - 1.4 9.0 25.4 1 9.4 19.1 3.0 2 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein RPW8 PF05659.11 ETO25806.1 - 3.3 7.4 9.6 2.1 8.0 1.5 3.1 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 Nicastrin PF05450.15 ETO25807.1 - 1.1e-36 126.4 0.5 2.1e-36 125.5 0.5 1.5 1 0 0 1 1 1 1 Nicastrin Peptidase_M28 PF04389.17 ETO25807.1 - 3.3e-05 23.7 1.0 7.5e-05 22.5 1.0 1.6 1 1 0 1 1 1 1 Peptidase family M28 Herpes_UL52 PF03121.15 ETO25808.1 - 3.9e-08 33.1 0.9 8.9e-08 32.0 0.9 1.6 1 0 0 1 1 1 1 Herpesviridae UL52/UL70 DNA primase TFIIS_M PF07500.14 ETO25809.1 - 1.1e-16 61.3 9.5 1.7e-16 60.7 4.9 3.5 3 1 1 4 4 4 2 Transcription factor S-II (TFIIS), central domain SPOC PF07744.13 ETO25809.1 - 5.6e-07 29.6 0.0 1.4e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 SPOC domain Pex14_N PF04695.13 ETO25810.1 - 0.0042 17.8 0.1 0.005 17.5 0.1 1.2 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Pkinase PF00069.25 ETO25813.1 - 5.3e-24 85.0 0.1 8.4e-24 84.3 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25813.1 - 1.9e-13 50.3 0.1 2.4e-13 50.0 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO25813.1 - 7.9e-06 25.4 0.1 1.4e-05 24.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO25813.1 - 0.0052 15.6 0.5 0.0097 14.7 0.0 1.6 2 0 0 2 2 2 1 Fungal protein kinase FhuF PF06276.12 ETO25813.1 - 0.084 13.3 0.0 0.14 12.6 0.0 1.4 1 0 0 1 1 1 0 Ferric iron reductase FhuF-like transporter DHHC PF01529.20 ETO25814.1 - 2.3e-27 95.7 8.6 2.3e-27 95.7 8.6 2.5 2 1 1 3 3 3 1 DHHC palmitoyltransferase FbpA PF05833.11 ETO25814.1 - 0.023 13.4 0.2 0.033 13.0 0.2 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ly49 PF08391.10 ETO25814.1 - 0.052 13.9 0.5 0.24 11.8 0.2 2.2 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region Herpes_LMP1 PF05297.11 ETO25814.1 - 3.4 6.8 4.2 2.5 7.2 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus latent membrane protein 1 (LMP1) RR_TM4-6 PF06459.12 ETO25815.1 - 0.0085 16.0 14.2 0.0085 16.0 14.2 1.7 2 0 0 2 2 2 1 Ryanodine Receptor TM 4-6 GREB1 PF15782.5 ETO25815.1 - 0.26 8.4 10.6 0.28 8.3 10.6 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF4647 PF15504.6 ETO25815.1 - 1.1 8.3 17.7 0.18 10.9 13.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4647) SID-1_RNA_chan PF13965.6 ETO25815.1 - 1.4 7.2 3.3 1.9 6.8 3.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Ndc1_Nup PF09531.10 ETO25815.1 - 1.6 7.4 8.7 1.8 7.2 8.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LMBR1 PF04791.16 ETO25815.1 - 1.7 7.5 8.7 2.1 7.2 8.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein CemA PF03040.14 ETO25815.1 - 1.9 8.4 4.5 3.3 7.6 4.5 1.4 1 0 0 1 1 1 0 CemA family O-antigen_lig PF13425.6 ETO25815.1 - 2.5 6.8 6.3 4.1 6.1 6.3 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein B56 PF01603.20 ETO25816.1 - 6.6e-54 183.5 9.7 5.4e-44 150.8 1.0 2.0 1 1 1 2 2 2 2 Protein phosphatase 2A regulatory B subunit (B56 family) SIR2 PF02146.17 ETO25817.1 - 1.1e-23 84.1 0.1 1.8e-17 63.8 0.0 2.5 1 1 1 2 2 2 2 Sir2 family TPP_enzyme_M PF00205.22 ETO25817.1 - 0.00053 19.7 0.1 0.18 11.5 0.0 2.3 2 0 0 2 2 2 2 Thiamine pyrophosphate enzyme, central domain DUF1951 PF09188.10 ETO25818.1 - 0.049 13.6 1.7 11 6.0 0.0 3.0 1 1 1 2 2 2 0 Domain of unknown function (DUF1951) RRN3 PF05327.11 ETO25820.1 - 2.1 6.8 7.5 2.9 6.3 7.5 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cys_rich_KTR PF14205.6 ETO25821.1 - 0.0061 16.3 0.3 0.015 15.1 0.3 1.7 1 0 0 1 1 1 1 Cysteine-rich KTR YtfJ_HI0045 PF09695.10 ETO25825.1 - 0.11 12.2 0.0 0.18 11.4 0.0 1.3 1 0 0 1 1 1 0 Bacterial protein of unknown function (YtfJ_HI0045) EMP24_GP25L PF01105.24 ETO25827.1 - 3.6e-05 23.8 0.6 5e-05 23.3 0.6 1.2 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD SAM_1 PF00536.30 ETO25829.1 - 1.1e-18 67.4 0.9 1.1e-08 35.4 0.2 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO25829.1 - 6.3e-13 48.6 0.3 1.7e-06 28.0 0.1 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO25829.1 - 0.002 18.3 0.0 0.036 14.3 0.0 2.7 2 0 0 2 2 2 1 Ste50p, sterile alpha motif SAM_PNT PF02198.16 ETO25829.1 - 0.0057 16.6 1.0 0.19 11.7 0.1 2.8 1 1 1 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain XRN_M PF17846.1 ETO25830.1 - 3.2e-39 135.2 14.8 5.4e-39 134.4 11.1 2.3 1 1 1 2 2 2 1 Xrn1 helical domain NST1 PF13945.6 ETO25830.1 - 0.0034 17.5 11.8 0.0034 17.5 11.8 2.3 2 0 0 2 2 2 1 Salt tolerance down-regulator DUF4519 PF15012.6 ETO25830.1 - 0.0047 17.1 2.1 0.013 15.7 2.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4519) UNC45-central PF11701.8 ETO25830.1 - 0.067 13.2 1.9 0.12 12.4 1.9 1.5 1 1 0 1 1 1 0 Myosin-binding striated muscle assembly central Orf78 PF06024.12 ETO25830.1 - 1.3 9.4 6.8 4.4 7.6 6.8 1.9 1 0 0 1 1 1 0 Orf78 (ac78) O-antigen_lig PF13425.6 ETO25830.1 - 2.9 6.6 7.1 5.1 5.8 7.1 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SGP PF17228.2 ETO25831.1 - 5.6e-05 23.9 4.6 0.00073 20.3 2.0 2.3 2 0 0 2 2 2 1 Sulphur globule protein CPSF100_C PF13299.6 ETO25831.1 - 0.049 13.8 0.8 0.049 13.8 0.8 1.9 1 1 1 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Patched PF02460.18 ETO25831.1 - 0.25 9.4 1.9 0.3 9.1 1.9 1.0 1 0 0 1 1 1 0 Patched family ATP-synt_F PF01990.17 ETO25832.1 - 0.81 10.1 5.3 0.28 11.5 1.0 2.5 2 1 0 2 2 2 0 ATP synthase (F/14-kDa) subunit ToxN_toxin PF13958.6 ETO25833.1 - 0.0022 18.3 1.0 0.0032 17.7 1.0 1.3 1 0 0 1 1 1 1 Toxin ToxN, type III toxin-antitoxin system Nsp1_C PF05064.13 ETO25833.1 - 0.011 15.5 3.5 0.02 14.7 3.5 1.4 1 0 0 1 1 1 0 Nsp1-like C-terminal region FAM76 PF16046.5 ETO25833.1 - 0.013 14.9 7.2 0.015 14.7 7.2 1.1 1 0 0 1 1 1 0 FAM76 protein DNA_primase_lrg PF04104.14 ETO25833.1 - 0.043 13.2 1.9 0.99 8.7 0.0 2.1 2 0 0 2 2 2 0 Eukaryotic and archaeal DNA primase, large subunit DUF4709 PF15821.5 ETO25833.1 - 0.12 12.7 7.7 0.29 11.5 7.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4709) Nup54 PF13874.6 ETO25833.1 - 0.47 10.6 6.6 0.79 9.8 6.6 1.3 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 TMPIT PF07851.13 ETO25833.1 - 3.4 6.8 7.3 4.8 6.3 7.3 1.1 1 0 0 1 1 1 0 TMPIT-like protein Transglut_core PF01841.19 ETO25834.1 - 0.00078 19.9 0.0 0.0019 18.6 0.0 1.7 2 0 0 2 2 2 1 Transglutaminase-like superfamily DUF4635 PF15466.6 ETO25836.1 - 0.0034 16.9 0.8 0.0076 15.8 0.8 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4635) Atg14 PF10186.9 ETO25836.1 - 0.39 9.8 8.7 0.45 9.6 8.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YjbH PF06082.11 ETO25836.1 - 1.2 7.9 5.3 1.4 7.6 5.3 1.0 1 0 0 1 1 1 0 Exopolysaccharide biosynthesis protein YbjH UPF0242 PF06785.11 ETO25836.1 - 1.9 8.6 12.4 2.4 8.2 12.4 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Phage_TAC_4 PF08748.11 ETO25837.1 - 0.12 12.7 1.6 0.38 11.1 0.3 2.3 2 0 0 2 2 2 0 Phage tail assembly chaperone BTB_2 PF02214.22 ETO25838.1 - 2.8e-05 24.4 0.5 0.00046 20.5 0.0 2.9 3 1 0 3 3 3 1 BTB/POZ domain PT PF04886.12 ETO25841.1 - 4.9e-29 99.6 137.9 0.00013 21.4 18.3 8.3 1 1 6 7 7 7 6 PT repeat Orf78 PF06024.12 ETO25842.1 - 0.0086 16.4 0.9 0.0086 16.4 0.9 3.3 3 2 0 3 3 3 1 Orf78 (ac78) DUF1676 PF07898.13 ETO25842.1 - 0.013 15.5 4.7 0.013 15.5 4.7 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Astro_capsid_p PF12226.8 ETO25842.1 - 3.6 6.7 7.5 6.1 5.9 7.5 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Pkinase PF00069.25 ETO25843.1 - 1.1e-33 116.7 6.3 1.6e-32 113.0 6.3 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25843.1 - 1.1e-21 77.4 4.3 2.2e-14 53.4 0.6 2.2 1 1 1 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO25843.1 - 2.7e-08 33.1 2.2 4.7e-08 32.4 2.2 1.4 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETO25843.1 - 9.1e-05 21.9 2.6 0.00027 20.3 0.3 2.3 1 1 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO25843.1 - 0.00011 22.2 0.0 0.00034 20.6 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family YukC PF10140.9 ETO25843.1 - 0.0032 16.4 0.2 0.02 13.7 0.0 2.0 1 1 1 2 2 2 1 WXG100 protein secretion system (Wss), protein YukC Kinase-like PF14531.6 ETO25843.1 - 0.023 14.0 0.3 0.078 12.3 0.0 1.8 2 0 0 2 2 2 0 Kinase-like FadA PF09403.10 ETO25843.1 - 0.047 14.2 0.2 0.11 13.0 0.2 1.6 1 0 0 1 1 1 0 Adhesion protein FadA DUF4470 PF14737.6 ETO25843.1 - 0.077 13.2 0.0 0.22 11.7 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4470) DUF3724 PF12521.8 ETO25843.1 - 0.22 11.5 2.2 0.54 10.3 2.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3724) DUF3439 PF11921.8 ETO25843.1 - 2.8 7.9 6.6 0.5 10.3 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Fmp27_GFWDK PF10347.9 ETO25844.1 - 3.9e-12 46.5 0.0 7.2e-12 45.7 0.0 1.4 1 0 0 1 1 1 1 RNA pol II promoter Fmp27 protein domain Ac76 PF05814.11 ETO25845.1 - 0.14 12.2 0.7 0.14 12.2 0.7 2.4 2 0 0 2 2 2 0 Orf76 (Ac76) Trypan_PARP PF05887.11 ETO25846.1 - 1.5e-05 25.0 11.4 1.5e-05 25.0 11.4 2.7 3 0 0 3 3 3 1 Procyclic acidic repetitive protein (PARP) Filament PF00038.21 ETO25846.1 - 0.0021 17.7 31.0 0.0021 17.7 31.0 5.4 2 1 2 4 4 4 1 Intermediate filament protein Taxilin PF09728.9 ETO25846.1 - 0.0026 17.0 18.4 0.0026 17.0 18.4 6.1 3 2 3 6 6 6 2 Myosin-like coiled-coil protein TPR_MLP1_2 PF07926.12 ETO25846.1 - 0.012 15.7 17.0 0.012 15.7 17.0 7.8 3 1 4 7 7 7 0 TPR/MLP1/MLP2-like protein LURAP PF14854.6 ETO25846.1 - 0.015 15.3 1.9 0.069 13.1 1.1 2.7 1 1 0 1 1 1 0 Leucine rich adaptor protein UVR PF02151.19 ETO25846.1 - 0.038 13.8 0.0 0.038 13.8 0.0 6.0 8 0 0 8 8 8 0 UvrB/uvrC motif Striatin PF08232.12 ETO25846.1 - 1.3 9.6 0.0 1.3 9.6 0.0 7.8 4 1 2 6 6 6 0 Striatin family SKIP_SNW PF02731.15 ETO25847.1 - 2.6e-35 121.5 3.3 2.6e-35 121.5 3.3 3.5 2 1 1 3 3 3 1 SKIP/SNW domain LMBR1 PF04791.16 ETO25847.1 - 8.2 5.2 11.3 14 4.4 11.3 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Mito_carr PF00153.27 ETO25848.1 - 4e-05 23.5 0.0 9.8e-05 22.2 0.0 1.7 1 0 0 1 1 1 1 Mitochondrial carrier protein SNF2_N PF00176.23 ETO25849.1 - 3e-19 68.9 0.1 8.2e-19 67.5 0.1 1.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain Ras PF00071.22 ETO25850.1 - 1.8e-05 24.4 0.6 0.02 14.5 0.2 2.2 2 0 0 2 2 2 2 Ras family WD40 PF00400.32 ETO25853.1 - 6.3e-09 36.3 0.6 0.0095 16.8 0.1 3.6 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25853.1 - 3.6e-05 24.0 0.0 1.3 9.4 0.0 4.5 1 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO25853.1 - 0.0061 16.5 0.0 0.047 13.6 0.0 2.2 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A VID27 PF08553.10 ETO25853.1 - 0.024 13.7 0.1 0.057 12.5 0.1 1.5 2 0 0 2 2 2 0 VID27 C-terminal WD40-like domain Yeast-kill-tox PF09207.11 ETO25853.1 - 0.048 14.3 0.1 15 6.3 0.0 2.6 2 0 0 2 2 2 0 Yeast killer toxin DUF4834 PF16118.5 ETO25854.1 - 0.02 15.8 0.7 0.02 15.8 0.7 7.6 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) YMF19 PF02326.15 ETO25854.1 - 0.024 15.4 1.8 0.024 15.4 1.8 3.6 3 1 1 4 4 4 0 Plant ATP synthase F0 DUF1980 PF09323.10 ETO25854.1 - 0.11 12.4 0.2 0.11 12.4 0.2 4.7 4 2 0 4 4 4 0 Domain of unknown function (DUF1980) Helicase_PWI PF18149.1 ETO25855.1 - 0.055 13.7 0.0 1.4 9.1 0.0 2.3 2 0 0 2 2 2 0 N-terminal helicase PWI domain Sec63 PF02889.16 ETO25856.1 - 3.7e-64 216.4 0.3 6.9e-64 215.5 0.3 1.5 1 0 0 1 1 1 1 Sec63 Brl domain DEAD PF00270.29 ETO25856.1 - 1.6e-32 112.7 0.3 1.5e-21 76.9 0.0 2.8 3 0 0 3 3 3 2 DEAD/DEAH box helicase ResIII PF04851.15 ETO25856.1 - 2.2e-15 57.1 0.0 5.5e-11 42.8 0.0 2.5 2 0 0 2 2 2 2 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO25856.1 - 6.5e-07 29.7 0.6 0.00011 22.5 0.2 3.7 3 1 0 3 3 3 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ETO25856.1 - 1.8e-05 25.0 0.4 0.014 15.6 0.0 3.0 2 1 0 2 2 2 2 AAA domain PI_PP_I PF18363.1 ETO25856.1 - 0.03 14.5 0.0 0.15 12.3 0.0 2.2 1 0 0 1 1 1 0 Phosphoinositide phosphatase insertion domain AAA PF00004.29 ETO25856.1 - 0.079 13.4 0.1 3 8.3 0.0 2.8 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) T2SSE PF00437.20 ETO25856.1 - 0.1 11.7 0.0 0.24 10.4 0.0 1.6 1 0 0 1 1 1 0 Type II/IV secretion system protein PAS_8 PF13188.7 ETO25856.1 - 0.11 12.5 0.1 5.6 7.1 0.0 3.2 2 0 0 2 2 2 0 PAS domain Importin_rep_4 PF18808.1 ETO25857.1 - 8.2e-12 45.3 0.0 8.2e-12 45.3 0.0 4.9 4 2 0 4 4 3 1 Importin repeat HEAT PF02985.22 ETO25857.1 - 1.2e-05 25.1 2.9 2.8 8.5 0.0 5.4 5 0 0 5 5 4 1 HEAT repeat HEAT_2 PF13646.6 ETO25857.1 - 5.1e-05 23.6 0.2 0.93 9.9 0.1 3.9 3 1 1 4 4 4 2 HEAT repeats Pox_Ag35 PF03286.14 ETO25857.1 - 0.00015 21.6 15.4 0.00074 19.4 5.8 2.3 2 0 0 2 2 2 2 Pox virus Ag35 surface protein Nop14 PF04147.12 ETO25857.1 - 0.00034 19.0 7.2 0.00034 19.0 7.2 2.1 2 0 0 2 2 2 1 Nop14-like family GCIP PF13324.6 ETO25857.1 - 0.00096 18.8 8.9 0.14 11.8 0.3 3.2 3 0 0 3 3 3 2 Grap2 and cyclin-D-interacting HEAT_EZ PF13513.6 ETO25857.1 - 0.0012 19.3 7.2 0.36 11.4 0.5 5.7 6 1 1 7 7 5 2 HEAT-like repeat CDC45 PF02724.14 ETO25857.1 - 0.0042 15.5 3.8 0.0042 15.5 3.8 2.1 2 0 0 2 2 2 1 CDC45-like protein DNA_pol_phi PF04931.13 ETO25857.1 - 0.0078 14.4 21.7 0.0089 14.2 7.1 2.3 2 0 0 2 2 2 2 DNA polymerase phi UBN_AB PF14075.6 ETO25857.1 - 0.0088 15.8 0.9 0.0088 15.8 0.9 3.1 3 1 0 3 3 2 1 Ubinuclein conserved middle domain BUD22 PF09073.10 ETO25857.1 - 0.014 14.8 15.8 0.18 11.1 5.3 2.1 2 0 0 2 2 2 0 BUD22 RRN3 PF05327.11 ETO25857.1 - 0.014 13.9 16.7 0.016 13.8 6.9 2.6 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 DUF913 PF06025.12 ETO25857.1 - 0.016 14.2 7.8 0.049 12.6 1.1 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) POX PF07526.11 ETO25857.1 - 0.022 15.3 6.9 0.87 10.2 1.0 2.6 2 0 0 2 2 2 0 Associated with HOX RIX1 PF08167.12 ETO25857.1 - 0.022 14.5 0.0 0.084 12.6 0.0 1.9 1 0 0 1 1 1 0 rRNA processing/ribosome biogenesis SpoIIP PF07454.11 ETO25857.1 - 0.031 13.7 12.1 0.91 8.9 0.1 2.3 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) SDA1 PF05285.12 ETO25857.1 - 0.072 12.5 21.4 0.12 11.7 9.2 2.4 2 0 0 2 2 2 0 SDA1 Vfa1 PF08432.10 ETO25857.1 - 0.15 12.3 18.8 1.1 9.6 7.0 2.6 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 CNDH2_C PF16858.5 ETO25857.1 - 0.28 11.0 16.7 0.93 9.3 6.9 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Arm PF00514.23 ETO25857.1 - 0.34 11.0 2.2 0.69 10.0 0.2 2.7 2 0 0 2 2 1 0 Armadillo/beta-catenin-like repeat DUF5523 PF17661.1 ETO25857.1 - 0.42 10.2 17.4 1.3 8.6 5.7 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Pes-10 PF07149.11 ETO25857.1 - 0.46 9.5 17.6 0.024 13.7 3.6 2.3 2 0 0 2 2 2 0 Pes-10 GET2 PF08690.10 ETO25857.1 - 0.47 10.1 7.2 0.063 13.0 0.4 2.2 2 0 0 2 2 2 0 GET complex subunit GET2 RPN2_C PF18004.1 ETO25857.1 - 0.63 9.9 20.5 0.25 11.3 1.7 2.6 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain Striatin PF08232.12 ETO25857.1 - 0.74 10.4 13.9 1.3 9.6 5.1 2.4 2 0 0 2 2 2 0 Striatin family Mpp10 PF04006.12 ETO25857.1 - 0.91 7.9 24.9 0.37 9.2 10.7 2.1 2 0 0 2 2 2 0 Mpp10 protein DRIM PF07539.12 ETO25857.1 - 1.5 7.0 8.4 1 7.6 1.1 3.3 3 2 0 3 3 3 0 Down-regulated in metastasis SAPS PF04499.15 ETO25857.1 - 2.1 7.0 12.7 0.067 12.0 1.7 2.2 2 0 0 2 2 2 0 SIT4 phosphatase-associated protein FAM176 PF14851.6 ETO25857.1 - 2.2 7.9 22.7 0.2 11.3 2.6 3.0 3 0 0 3 3 2 0 FAM176 family Gti1_Pac2 PF09729.9 ETO25857.1 - 2.3 8.3 11.5 16 5.5 6.9 2.3 2 0 0 2 2 2 0 Gti1/Pac2 family DUF719 PF05334.13 ETO25857.1 - 2.3 8.4 7.1 7.5 6.7 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF719) Eapp_C PF10238.9 ETO25857.1 - 2.4 8.2 16.3 0.41 10.7 1.2 2.9 3 0 0 3 3 3 0 E2F-associated phosphoprotein DUF2052 PF09747.9 ETO25857.1 - 2.7 8.1 27.5 0.11 12.6 4.9 3.1 2 1 1 3 3 3 0 Coiled-coil domain containing protein (DUF2052) DUF4820 PF16091.5 ETO25857.1 - 2.8 7.2 18.5 1.7 7.9 4.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) RNA_pol_Rpc4 PF05132.14 ETO25857.1 - 3.1 8.2 13.3 9.4 6.7 2.2 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Androgen_recep PF02166.16 ETO25857.1 - 4.2 6.1 7.5 6.6 5.4 7.5 1.2 1 0 0 1 1 1 0 Androgen receptor FYDLN_acid PF09538.10 ETO25857.1 - 5.4 7.7 22.1 1 10.1 2.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) NPR3 PF03666.13 ETO25857.1 - 7.6 5.2 18.3 0.15 10.8 4.3 2.4 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 zf-C2H2 PF00096.26 ETO25858.1 - 1.1e-13 50.9 29.0 2.7e-06 27.5 0.4 4.6 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO25858.1 - 4.5e-11 42.7 31.5 0.0009 19.6 2.8 4.5 4 0 0 4 4 4 4 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO25858.1 - 2.3e-08 34.1 26.3 0.00018 22.0 0.3 4.6 4 0 0 4 4 4 2 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETO25858.1 - 5.9e-06 26.4 21.5 0.00029 21.1 1.8 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETO25858.1 - 9e-06 25.9 5.5 0.0018 18.6 0.7 3.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type HNH_5 PF14279.6 ETO25858.1 - 0.0028 17.5 7.2 0.033 14.1 1.9 2.5 2 0 0 2 2 2 1 HNH endonuclease zf-BED PF02892.15 ETO25858.1 - 0.011 15.7 2.3 0.011 15.7 2.3 4.0 3 1 1 4 4 4 0 BED zinc finger ROS_MUCR PF05443.11 ETO25858.1 - 0.015 15.4 1.2 0.032 14.3 1.0 1.7 2 0 0 2 2 2 0 ROS/MUCR transcriptional regulator protein Sprouty PF05210.13 ETO25858.1 - 0.033 14.6 1.7 0.033 14.6 1.7 2.5 3 0 0 3 3 3 0 Sprouty protein (Spry) zf-C2HC_2 PF13913.6 ETO25858.1 - 0.088 12.7 0.5 0.088 12.7 0.5 4.1 4 0 0 4 4 3 0 zinc-finger of a C2HC-type DUF629 PF04780.12 ETO25858.1 - 0.093 11.2 11.5 0.13 10.7 0.9 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF629) zf-C2H2_3rep PF18868.1 ETO25858.1 - 0.097 13.3 15.1 0.072 13.8 1.8 3.2 1 1 4 5 5 5 0 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 ETO25858.1 - 0.38 10.4 0.2 0.38 10.4 0.2 3.3 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-C2H2_2 PF12756.7 ETO25858.1 - 0.42 11.0 18.2 0.52 10.7 3.1 3.1 1 1 1 3 3 3 0 C2H2 type zinc-finger (2 copies) XPA_N PF01286.18 ETO25858.1 - 4.9 7.3 16.0 2.2 8.4 0.6 3.8 3 0 0 3 3 3 0 XPA protein N-terminal Ribosomal_L37ae PF01780.19 ETO25858.1 - 5.8 7.1 12.4 5 7.3 1.5 3.2 2 1 1 3 3 3 0 Ribosomal L37ae protein family Porph_ging PF09697.10 ETO25859.1 - 0.14 12.7 0.1 0.14 12.7 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (Porph_ging) EF-hand_1 PF00036.32 ETO25860.1 - 5.2e-25 85.1 11.4 2.6e-07 29.7 0.1 4.4 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO25860.1 - 5.1e-23 79.0 6.5 1.8e-05 24.3 0.2 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ETO25860.1 - 1.1e-21 77.0 13.8 1e-12 48.3 2.5 3.3 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO25860.1 - 2.8e-15 55.0 13.9 5.5e-05 22.5 0.1 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO25860.1 - 3.4e-10 39.6 13.9 1.2e-06 28.2 1.2 3.7 1 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO25860.1 - 0.0011 19.2 5.4 0.18 12.1 0.1 3.5 3 0 0 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 ETO25860.1 - 0.0048 17.7 0.1 0.63 10.9 0.1 3.2 1 1 2 3 3 3 1 EF-hand domain EF-hand_9 PF14658.6 ETO25860.1 - 0.052 13.9 0.2 5.7 7.4 0.0 2.6 2 0 0 2 2 2 0 EF-hand domain p25-alpha PF05517.12 ETO25860.1 - 0.086 13.0 5.7 0.2 11.8 0.1 3.3 3 2 0 3 3 3 0 p25-alpha EF-hand_4 PF12763.7 ETO25860.1 - 0.17 11.8 6.7 6.9 6.7 1.1 3.3 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 ETO25860.1 - 0.24 11.3 5.2 12 5.8 0.1 4.0 3 1 1 4 4 4 0 EF hand Ca_bind_SSO6904 PF18249.1 ETO25860.1 - 0.25 11.7 1.4 6.3 7.2 0.2 2.4 1 1 1 2 2 2 0 Calcium binding protein SSO6904 ELO PF01151.18 ETO25861.1 - 0.0094 15.5 1.4 0.015 14.8 1.4 1.2 1 0 0 1 1 1 1 GNS1/SUR4 family DUF5349 PF17298.2 ETO25861.1 - 1.2 8.8 21.7 1.7 8.3 21.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5349) RabGAP-TBC PF00566.18 ETO25862.1 - 2.5e-46 158.0 9.3 1.8e-40 138.9 2.5 2.4 3 0 0 3 3 3 2 Rab-GTPase-TBC domain HEAT_EZ PF13513.6 ETO25863.1 - 7e-05 23.2 2.1 8.8 7.0 0.0 4.9 4 1 1 5 5 5 3 HEAT-like repeat HEAT PF02985.22 ETO25863.1 - 0.1 12.9 1.2 9.4 6.8 0.1 3.7 2 1 0 2 2 2 0 HEAT repeat Tom22 PF04281.13 ETO25864.1 - 0.16 11.8 0.0 0.27 11.0 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 CBM_20 PF00686.19 ETO25865.1 - 0.16 11.9 0.1 0.63 10.0 0.0 1.9 2 0 0 2 2 2 0 Starch binding domain Proteasom_Rpn13 PF04683.13 ETO25866.1 - 1.2e-10 41.8 0.0 3.1e-10 40.5 0.0 1.8 1 0 0 1 1 1 1 Proteasome complex subunit Rpn13 ubiquitin receptor DMA PF03474.14 ETO25866.1 - 0.00094 18.7 0.0 0.0019 17.7 0.0 1.5 1 0 0 1 1 1 1 DMRTA motif HTH_8 PF02954.19 ETO25866.1 - 0.037 13.8 0.0 0.08 12.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial regulatory protein, Fis family Acetyltransf_1 PF00583.25 ETO25867.1 - 7.5e-07 29.4 0.0 5.2e-06 26.7 0.0 2.2 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO25867.1 - 4.2e-05 23.5 0.2 0.0044 16.9 0.0 2.3 2 0 0 2 2 2 2 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO25867.1 - 0.00015 22.1 0.0 0.0059 17.0 0.0 2.3 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO25867.1 - 0.018 15.0 0.0 0.16 12.0 0.0 2.0 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_9 PF13527.7 ETO25867.1 - 0.04 14.0 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain SPRY PF00622.28 ETO25868.1 - 0.023 14.8 0.0 0.027 14.6 0.0 1.1 1 0 0 1 1 1 0 SPRY domain Myb_DNA-binding PF00249.31 ETO25868.1 - 0.054 13.7 0.0 0.07 13.3 0.0 1.2 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF2116 PF09889.9 ETO25869.1 - 0.017 15.1 1.1 0.035 14.1 0.3 2.0 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) SH3_3 PF08239.11 ETO25870.1 - 0.031 14.5 0.1 0.092 13.0 0.0 1.8 2 0 0 2 2 2 0 Bacterial SH3 domain NST1 PF13945.6 ETO25870.1 - 5.8 7.0 28.5 10 6.1 21.5 2.5 2 0 0 2 2 2 0 Salt tolerance down-regulator Macoilin PF09726.9 ETO25870.1 - 9 4.7 17.3 11 4.4 17.3 1.3 1 0 0 1 1 1 0 Macoilin family PI3K_P85_iSH2 PF16454.5 ETO25871.1 - 0.071 12.7 0.3 0.11 12.1 0.3 1.2 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain zf-rbx1 PF12678.7 ETO25871.1 - 0.77 10.1 14.1 0.55 10.6 10.1 2.5 2 1 0 2 2 2 0 RING-H2 zinc finger domain Zn_ribbon_17 PF17120.5 ETO25871.1 - 9.6 5.9 20.5 0.057 13.1 8.6 2.7 2 1 1 3 3 3 0 Zinc-ribbon, C4HC2 type WD40 PF00400.32 ETO25872.1 - 1.1e-11 45.1 5.2 0.00054 20.7 0.0 5.7 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25872.1 - 0.0003 21.0 0.1 0.0095 16.2 0.0 3.5 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Rap1_C PF11626.8 ETO25872.1 - 0.14 12.3 0.3 3.3 7.9 0.0 2.8 2 0 0 2 2 2 0 TRF2-interacting telomeric protein/Rap1 - C terminal domain AAA_33 PF13671.6 ETO25874.1 - 3.3e-09 37.0 0.3 1.2e-08 35.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO25874.1 - 3.4e-06 27.6 0.6 7.4e-06 26.5 0.0 2.0 2 1 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO25874.1 - 0.00019 21.7 0.3 0.0006 20.1 0.3 1.9 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO25874.1 - 0.00051 20.5 0.0 0.0012 19.3 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain KTI12 PF08433.10 ETO25874.1 - 0.00073 19.1 0.0 0.0014 18.1 0.0 1.5 1 1 0 1 1 1 1 Chromatin associated protein KTI12 AAA_28 PF13521.6 ETO25874.1 - 0.0015 18.8 0.1 0.0031 17.8 0.0 1.7 2 0 0 2 2 1 1 AAA domain NACHT PF05729.12 ETO25874.1 - 0.0037 17.2 0.0 0.0061 16.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain Zeta_toxin PF06414.12 ETO25874.1 - 0.0075 15.6 0.1 0.021 14.1 0.1 1.7 1 0 0 1 1 1 1 Zeta toxin Viral_helicase1 PF01443.18 ETO25874.1 - 0.013 15.2 0.0 0.022 14.5 0.0 1.4 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NB-ARC PF00931.22 ETO25874.1 - 0.017 14.3 0.0 0.024 13.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA PF00004.29 ETO25874.1 - 0.019 15.4 0.0 0.033 14.6 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ETO25874.1 - 0.019 15.4 1.3 0.041 14.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ETO25874.1 - 0.028 14.4 0.3 0.077 13.0 0.1 1.8 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_25 PF13481.6 ETO25874.1 - 0.031 13.9 0.1 0.2 11.2 0.1 2.0 2 0 0 2 2 2 0 AAA domain AAA_5 PF07728.14 ETO25874.1 - 0.037 14.0 0.0 0.097 12.7 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) SRP54 PF00448.22 ETO25874.1 - 0.038 13.6 0.0 0.073 12.7 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain dNK PF01712.19 ETO25874.1 - 0.041 13.7 0.0 0.059 13.2 0.0 1.3 1 0 0 1 1 1 0 Deoxynucleoside kinase AAA_14 PF13173.6 ETO25874.1 - 0.044 13.8 0.0 0.08 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain cobW PF02492.19 ETO25874.1 - 0.052 13.1 0.1 0.09 12.4 0.1 1.3 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain 6PF2K PF01591.18 ETO25874.1 - 0.053 12.8 0.0 0.12 11.7 0.0 1.6 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_30 PF13604.6 ETO25874.1 - 0.071 12.8 0.1 0.16 11.7 0.1 1.5 1 0 0 1 1 1 0 AAA domain PEPCK_ATP PF01293.20 ETO25874.1 - 0.075 11.7 0.0 0.11 11.1 0.0 1.2 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxykinase ADK PF00406.22 ETO25874.1 - 0.087 12.9 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 Adenylate kinase RuvB_N PF05496.12 ETO25874.1 - 0.11 12.3 0.0 0.17 11.6 0.0 1.2 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Hydin_ADK PF17213.3 ETO25874.1 - 0.44 10.8 2.8 2.2 8.5 0.0 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain EF-hand_6 PF13405.6 ETO25875.1 - 0.012 15.5 0.2 0.11 12.5 0.0 2.7 3 0 0 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 ETO25875.1 - 0.35 11.4 2.5 0.44 11.0 0.2 2.4 2 0 0 2 2 2 0 EF-hand domain pair Pkinase PF00069.25 ETO25876.1 - 3.6e-09 36.4 0.0 7.4e-09 35.3 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO25876.1 - 0.0022 17.3 0.0 0.0039 16.5 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase zf-RING_2 PF13639.6 ETO25877.1 - 3.1e-09 37.0 13.4 3.1e-09 37.0 13.4 2.0 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ETO25877.1 - 2.9e-06 27.5 11.8 8.9e-06 25.9 11.8 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO25877.1 - 1.6e-05 24.9 6.3 1.6e-05 24.9 6.3 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ETO25877.1 - 0.00023 20.9 15.2 0.00057 19.6 12.7 2.5 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_5 PF14634.6 ETO25877.1 - 0.00071 19.5 12.9 0.0016 18.4 12.9 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO25877.1 - 0.0013 18.5 15.1 0.0013 18.5 15.1 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO25877.1 - 0.0014 18.5 11.7 0.0014 18.5 11.7 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO25877.1 - 0.0028 17.4 15.6 0.012 15.5 13.8 2.5 2 1 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Zn_ribbon_17 PF17120.5 ETO25877.1 - 0.016 14.8 9.7 0.034 13.8 9.7 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 ETO25877.1 - 0.03 14.3 12.9 0.046 13.7 11.7 2.0 2 0 0 2 2 2 0 RING-type zinc-finger RINGv PF12906.7 ETO25877.1 - 0.038 14.1 12.9 0.092 12.9 12.9 1.7 1 0 0 1 1 1 0 RING-variant domain Baculo_RING PF05883.11 ETO25877.1 - 0.044 13.8 3.4 0.1 12.6 3.4 1.6 1 0 0 1 1 1 0 Baculovirus U-box/Ring-like domain FANCL_C PF11793.8 ETO25877.1 - 5.6 7.2 12.6 24 5.2 12.6 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain Peptidase_C14 PF00656.22 ETO25878.1 - 3.1e-16 60.1 1.3 5.8e-16 59.2 0.8 1.7 2 0 0 2 2 2 1 Caspase domain DUF772 PF05598.11 ETO25878.1 - 0.019 15.0 2.7 3.1 7.9 0.3 2.5 2 0 0 2 2 2 0 Transposase domain (DUF772) MatP_C PF17414.2 ETO25878.1 - 0.037 14.2 0.5 0.13 12.5 0.5 1.9 1 0 0 1 1 1 0 MatP C-terminal ribbon-helix-helix domain Neur_chan_memb PF02932.16 ETO25879.1 - 0.53 10.3 6.4 0.66 10.0 6.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region VIT1 PF01988.19 ETO25879.1 - 1.9 8.3 6.9 0.34 10.7 3.1 1.6 1 1 1 2 2 2 0 VIT family AAA_23 PF13476.6 ETO25879.1 - 2.4 8.6 15.3 4.8 7.6 15.3 1.5 1 0 0 1 1 1 0 AAA domain DUF2868 PF11067.8 ETO25879.1 - 4 6.8 7.4 5.4 6.4 7.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) PIN_4 PF13638.6 ETO25880.1 - 0.014 15.7 0.5 0.18 12.1 0.0 2.6 2 0 0 2 2 2 0 PIN domain DUF5470 PF17564.2 ETO25880.1 - 0.23 11.7 6.5 0.17 12.1 0.6 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5470) DUF3784 PF12650.7 ETO25883.1 - 0.012 15.8 1.8 0.03 14.5 1.8 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) Defensin_big PF14862.6 ETO25883.1 - 0.044 14.1 0.4 0.1 12.9 0.4 1.6 1 0 0 1 1 1 0 Big defensin CbiQ PF02361.16 ETO25883.1 - 0.14 11.7 3.7 0.2 11.2 3.7 1.2 1 0 0 1 1 1 0 Cobalt transport protein Ku_PK_bind PF08785.11 ETO25883.1 - 0.22 11.7 1.5 0.31 11.2 0.7 1.6 2 0 0 2 2 2 0 Ku C terminal domain like zf-RING_7 PF02591.15 ETO25884.1 - 0.23 11.6 0.1 32 4.8 0.0 2.8 2 1 1 3 3 3 0 C4-type zinc ribbon domain Ribosomal_S3_C PF00189.20 ETO25885.1 - 6.2e-13 49.1 2.9 2.3e-08 34.4 0.1 3.2 3 1 0 3 3 3 2 Ribosomal protein S3, C-terminal domain KH_2 PF07650.17 ETO25885.1 - 5.5e-09 35.7 0.2 1.1e-08 34.8 0.2 1.5 1 0 0 1 1 1 1 KH domain CFIA_Pcf11 PF11526.8 ETO25886.1 - 0.0059 17.1 0.7 0.0059 17.1 0.7 4.3 2 2 1 3 3 3 1 Subunit of cleavage factor IA Pcf11 FAIM1 PF06905.13 ETO25889.1 - 0.0044 16.8 2.9 0.0055 16.4 1.8 1.7 1 1 1 2 2 2 1 Fas apoptotic inhibitory molecule (FAIM1) SAS-6_N PF16531.5 ETO25889.1 - 0.13 12.9 1.4 0.26 11.9 0.1 2.1 2 1 0 2 2 2 0 Centriolar protein SAS N-terminal TagA PF12561.8 ETO25889.1 - 0.22 11.9 2.7 0.28 11.6 1.3 1.9 1 1 1 2 2 2 0 ToxR activated gene A lipoprotein domain zf-RanBP PF00641.18 ETO25891.1 - 3.5e-07 29.4 3.1 1.7e-06 27.2 3.1 2.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others DUF2076 PF09849.9 ETO25891.1 - 0.26 11.3 17.0 0.38 10.8 17.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Neur_chan_memb PF02932.16 ETO25891.1 - 0.38 10.8 2.6 0.53 10.3 2.6 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Macoilin PF09726.9 ETO25891.1 - 0.54 8.8 18.1 0.68 8.4 18.1 1.1 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 ETO25891.1 - 0.85 8.8 8.7 1.3 8.2 8.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO25891.1 - 0.97 8.1 13.8 1.3 7.8 13.8 1.2 1 0 0 1 1 1 0 Presenilin XRN_M PF17846.1 ETO25891.1 - 1.7 7.5 12.2 2.5 6.9 12.2 1.2 1 0 0 1 1 1 0 Xrn1 helical domain ASD2 PF08687.11 ETO25891.1 - 1.8 8.1 9.3 2.4 7.6 9.3 1.2 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 SLC12 PF03522.15 ETO25891.1 - 1.9 7.4 17.1 3.4 6.6 15.3 1.9 2 0 0 2 2 2 0 Solute carrier family 12 ALMT PF11744.8 ETO25891.1 - 2.9 6.6 12.8 3.8 6.2 12.8 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter HCO3_cotransp PF00955.21 ETO25891.1 - 4.9 5.9 9.2 7.8 5.2 9.2 1.5 1 0 0 1 1 1 0 HCO3- transporter family Gti1_Pac2 PF09729.9 ETO25891.1 - 5.1 7.2 15.1 7.6 6.6 15.1 1.4 1 0 0 1 1 1 0 Gti1/Pac2 family Dapper PF15268.6 ETO25891.1 - 9.5 4.9 11.5 11 4.7 11.5 1.0 1 0 0 1 1 1 0 Dapper IQ PF00612.27 ETO25892.1 - 3.2e-08 32.7 14.9 0.0087 15.8 2.4 4.0 3 0 0 3 3 3 3 IQ calmodulin-binding motif Pyrid_ox_like PF16242.5 ETO25893.1 - 2.2e-05 24.1 0.0 4.7e-05 23.0 0.0 1.5 1 1 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase like DiS_P_DiS PF06750.13 ETO25893.1 - 0.055 13.6 2.0 4.6 7.4 0.1 2.6 2 0 0 2 2 2 0 Bacterial Peptidase A24 N-terminal domain Putative_PNPOx PF01243.20 ETO25893.1 - 0.13 12.5 0.0 0.31 11.2 0.0 1.6 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase SH3_1 PF00018.28 ETO25895.1 - 3.9e-14 52.0 0.1 6.5e-14 51.3 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETO25895.1 - 3.1e-11 42.8 0.2 5.2e-11 42.1 0.2 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_9 PF14604.6 ETO25895.1 - 3.8e-11 42.7 0.1 6.3e-11 42.0 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain Ferric_reduct PF01794.19 ETO25896.1 - 1.5e-18 67.1 10.2 2e-18 66.7 8.7 1.8 2 0 0 2 2 2 1 Ferric reductase like transmembrane component N6_N4_Mtase PF01555.18 ETO25896.1 - 0.019 14.7 0.4 0.03 14.0 0.4 1.3 1 0 0 1 1 1 0 DNA methylase Baculo_11_kDa PF06143.11 ETO25896.1 - 0.13 11.9 0.2 2.8 7.6 0.1 2.7 2 0 0 2 2 2 0 Baculovirus 11 kDa family DHHC PF01529.20 ETO25896.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.5 2 1 0 2 2 2 0 DHHC palmitoyltransferase DUF4405 PF14358.6 ETO25896.1 - 0.6 10.7 0.1 0.6 10.7 0.1 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4405) BAR_3 PF16746.5 ETO25897.1 - 0.00067 19.4 2.8 0.00067 19.4 2.8 1.7 2 0 0 2 2 2 1 BAR domain of APPL family TBK1_ULD PF18396.1 ETO25897.1 - 0.015 15.2 0.2 0.69 9.9 0.1 2.4 2 0 0 2 2 2 0 TANK binding kinase 1 ubiquitin-like domain ATP-gua_Ptrans PF00217.19 ETO25899.1 - 1.2e-09 38.0 0.4 1.8e-07 30.9 0.4 2.1 1 1 0 1 1 1 1 ATP:guanido phosphotransferase, C-terminal catalytic domain Phage_prot_Gp6 PF05133.14 ETO25899.1 - 0.034 13.2 0.1 0.05 12.7 0.1 1.2 1 0 0 1 1 1 0 Phage portal protein, SPP1 Gp6-like ATP-gua_PtransN PF02807.15 ETO25900.1 - 3.8e-20 72.0 0.1 1.8e-19 69.9 0.0 2.2 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, N-terminal domain ATP-gua_Ptrans PF00217.19 ETO25900.1 - 1.4e-06 28.0 0.0 1.4e-06 28.0 0.0 1.6 2 0 0 2 2 2 1 ATP:guanido phosphotransferase, C-terminal catalytic domain WD40 PF00400.32 ETO25903.1 - 1.7e-43 145.7 28.8 1.1e-07 32.4 0.2 8.1 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25903.1 - 1.9e-11 44.1 1.5 0.089 13.1 0.0 5.8 6 1 0 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO25903.1 - 5.8e-11 41.7 3.0 0.036 12.7 0.1 5.8 2 1 3 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO25903.1 - 4.8e-05 22.8 0.7 0.45 9.8 0.0 4.3 5 0 0 5 5 5 2 WD40-like domain V-ATPase_C PF03223.15 ETO25903.1 - 0.01 15.3 2.4 0.01 15.3 2.4 2.8 2 1 1 3 3 3 1 V-ATPase subunit C Kazal_1 PF00050.21 ETO25903.1 - 0.03 14.4 0.1 0.09 12.8 0.1 1.8 1 0 0 1 1 1 0 Kazal-type serine protease inhibitor domain DUF5096 PF17019.5 ETO25903.1 - 0.051 13.4 6.1 0.056 13.2 1.3 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5096) YfhO PF09586.10 ETO25903.1 - 4.7 5.3 14.4 6.6 4.8 14.4 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO 4HBT PF03061.22 ETO25904.1 - 9.2e-10 38.7 0.2 1.8e-09 37.8 0.2 1.5 1 1 0 1 1 1 1 Thioesterase superfamily DUF730 PF05325.11 ETO25905.1 - 0.051 13.6 0.0 0.11 12.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF730) Anoctamin PF04547.12 ETO25906.1 - 6.5e-91 305.4 13.4 4.4e-46 157.6 12.8 2.2 1 1 1 2 2 2 2 Calcium-activated chloride channel AI-2E_transport PF01594.16 ETO25906.1 - 0.029 13.5 0.0 0.029 13.5 0.0 3.5 3 0 0 3 3 3 0 AI-2E family transporter SAM_1 PF00536.30 ETO25906.1 - 0.03 14.7 0.1 0.07 13.6 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) ABC2_membrane_4 PF12730.7 ETO25906.1 - 0.82 9.6 10.5 0.7 9.8 0.5 2.8 2 0 0 2 2 2 0 ABC-2 family transporter protein ERCC4 PF02732.15 ETO25907.1 - 0.014 15.6 0.4 0.032 14.5 0.4 1.5 1 0 0 1 1 1 0 ERCC4 domain FF PF01846.19 ETO25908.1 - 2.4e-10 40.4 13.9 1.1e-08 35.1 0.1 4.5 3 1 1 4 4 4 3 FF domain EIF4E-T PF10477.9 ETO25908.1 - 0.017 14.0 12.0 3.1 6.5 3.3 2.9 1 1 1 3 3 3 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E GAGA_bind PF06217.12 ETO25908.1 - 2.8 8.2 11.3 4.1 7.6 4.7 2.1 2 0 0 2 2 2 0 GAGA binding protein-like family DUF2252 PF10009.9 ETO25908.1 - 8.1 5.4 10.6 0.67 8.9 3.6 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2252) UBA PF00627.31 ETO25909.1 - 5.5e-09 35.8 0.4 9.6e-09 35.0 0.4 1.4 1 0 0 1 1 1 1 UBA/TS-N domain RGI1 PF10843.8 ETO25909.1 - 0.0088 15.7 0.4 0.0097 15.6 0.4 1.0 1 0 0 1 1 1 1 Respiratory growth induced protein 1 HOIP-UBA PF16678.5 ETO25909.1 - 0.025 14.6 0.0 0.034 14.2 0.0 1.2 1 0 0 1 1 1 0 HOIP UBA domain pair Menin PF05053.13 ETO25910.1 - 0.15 10.4 6.1 0.23 9.8 6.1 1.2 1 0 0 1 1 1 0 Menin MRNIP PF15749.5 ETO25910.1 - 0.63 10.8 8.4 2 9.2 8.4 1.9 1 0 0 1 1 1 0 MRN-interacting protein SpoIIE PF07228.12 ETO25911.1 - 0.028 14.3 0.0 0.52 10.2 0.0 2.0 1 1 0 1 1 1 0 Stage II sporulation protein E (SpoIIE) RE_AlwI PF09491.10 ETO25911.1 - 0.034 13.0 0.0 0.037 12.8 0.0 1.0 1 0 0 1 1 1 0 AlwI restriction endonuclease DUF5397 PF17375.2 ETO25911.1 - 0.11 12.2 0.0 0.26 11.0 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5397) AAA PF00004.29 ETO25912.1 - 0.00011 22.7 0.1 0.00037 20.9 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO25912.1 - 0.00027 21.5 0.1 0.0011 19.6 0.0 1.8 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO25912.1 - 0.0075 16.7 0.1 0.094 13.1 0.0 2.3 3 0 0 3 3 3 1 AAA ATPase domain AAA_17 PF13207.6 ETO25912.1 - 0.0087 16.5 0.4 0.039 14.4 0.1 2.0 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ETO25912.1 - 0.022 14.7 0.5 0.078 12.9 0.1 2.0 2 1 0 2 2 2 0 NACHT domain AAA_22 PF13401.6 ETO25912.1 - 0.023 15.0 0.1 0.05 13.9 0.0 1.6 2 0 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ETO25912.1 - 0.029 14.1 0.1 0.049 13.4 0.1 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase AAA_19 PF13245.6 ETO25912.1 - 0.062 13.6 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO25912.1 - 0.076 13.4 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 RNA helicase RuvB_N PF05496.12 ETO25912.1 - 0.15 11.8 0.0 0.41 10.4 0.0 1.7 2 0 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA PF00004.29 ETO25913.1 - 4.4e-08 33.6 0.0 9e-08 32.6 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_10 PF17872.1 ETO25913.1 - 6.7e-07 29.4 0.0 1.5e-06 28.2 0.0 1.6 1 0 0 1 1 1 1 AAA lid domain AAA_22 PF13401.6 ETO25913.1 - 0.024 14.9 0.0 0.059 13.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain Glyco_hydro_18 PF00704.28 ETO25914.1 - 6.3e-06 26.1 0.1 1.7e-05 24.7 0.1 1.4 1 1 0 1 1 1 1 Glycosyl hydrolases family 18 WD40 PF00400.32 ETO25915.1 - 3.8e-61 201.6 23.3 1.5e-09 38.3 0.6 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25915.1 - 1.7e-22 79.5 3.2 2.1e-05 24.7 0.1 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25915.1 - 3.6e-13 49.2 6.6 0.014 14.4 0.0 6.1 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO25915.1 - 3e-12 46.8 1.9 1.7e-08 34.6 0.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO25915.1 - 1.7e-11 44.0 5.6 0.00027 20.4 0.0 3.1 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO25915.1 - 3.8e-07 29.2 11.7 0.082 11.5 0.3 4.9 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO25915.1 - 0.00087 18.4 3.0 0.004 16.3 3.0 2.1 1 1 1 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO25915.1 - 0.0014 17.2 1.1 0.098 11.2 0.1 3.0 1 1 5 6 6 6 2 Cytochrome D1 heme domain IKI3 PF04762.12 ETO25915.1 - 0.0098 13.9 2.1 0.045 11.7 0.1 2.0 1 1 1 2 2 2 1 IKI3 family Nbas_N PF15492.6 ETO25915.1 - 0.018 14.4 3.3 0.29 10.4 1.0 3.2 1 1 0 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF5051 PF16473.5 ETO25915.1 - 0.099 12.6 1.3 1.4 8.9 0.0 2.7 2 1 0 2 2 2 0 3' exoribonuclease, RNase T-like DUF4072 PF13284.6 ETO25915.1 - 0.19 12.2 0.0 28 5.3 0.0 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF4072) Caudo_bapla_RBP PF08931.10 ETO25915.1 - 0.23 10.9 1.9 8.9 5.7 0.8 2.7 1 1 2 3 3 3 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head PD40 PF07676.12 ETO25915.1 - 1.4 8.9 5.9 39 4.4 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO25916.1 - 2.2e-50 167.5 8.1 7.2e-09 36.1 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25916.1 - 3.4e-20 72.2 3.9 0.01 16.1 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO25916.1 - 1.9e-12 47.5 0.2 3.1e-05 23.9 0.0 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO25916.1 - 3.2e-09 36.2 0.7 0.11 11.4 0.0 5.4 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO25916.1 - 3.2e-08 33.3 0.9 0.0032 16.8 0.3 3.0 1 1 3 4 4 4 4 WD40-like domain PD40 PF07676.12 ETO25916.1 - 2.2e-06 27.4 0.9 15 5.6 0.0 6.2 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO25916.1 - 0.00024 19.9 1.9 0.64 8.6 0.1 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO25916.1 - 0.0014 18.5 0.0 23 5.1 0.0 4.5 5 0 0 5 5 5 0 PQQ enzyme repeat Utp8 PF10395.9 ETO25916.1 - 0.0048 15.5 3.4 1.7 7.1 0.1 3.4 1 1 0 2 2 2 1 Utp8 family Str_synth PF03088.16 ETO25916.1 - 0.0069 16.5 0.0 1.7 8.8 0.0 3.0 3 0 0 3 3 3 1 Strictosidine synthase DPPIV_N PF00930.21 ETO25916.1 - 0.0069 15.2 0.4 0.91 8.2 0.1 3.5 2 2 2 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5046 PF16465.5 ETO25916.1 - 0.017 14.6 0.0 0.037 13.5 0.0 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) Nucleoporin_N PF08801.11 ETO25916.1 - 0.019 13.7 5.5 0.63 8.7 4.2 3.5 1 1 1 2 2 2 0 Nup133 N terminal like OapA PF04225.12 ETO25916.1 - 0.048 13.8 1.0 4.1 7.6 0.1 3.5 2 1 3 5 5 5 0 Opacity-associated protein A LysM-like domain Gelsolin PF00626.22 ETO25917.1 - 0.033 14.1 0.2 0.075 12.9 0.2 1.6 1 0 0 1 1 1 0 Gelsolin repeat NIF PF03031.18 ETO25918.1 - 1.9e-24 86.2 0.3 4.1e-24 85.1 0.3 1.6 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 ETO25918.1 - 4e-10 39.9 0.3 1.2e-09 38.5 0.3 1.9 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ETO25918.1 - 5.2e-08 33.2 0.0 1.8e-07 31.5 0.0 1.9 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain PTCB-BRCT PF12738.7 ETO25918.1 - 3.1e-06 27.1 0.3 7.3e-06 25.9 0.3 1.7 1 0 0 1 1 1 1 twin BRCT domain Biotin_lipoyl_2 PF13533.6 ETO25918.1 - 0.00013 21.8 0.1 0.00028 20.6 0.1 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 ETO25918.1 - 0.0038 17.0 0.1 0.0081 16.0 0.1 1.5 1 0 0 1 1 1 1 Biotin-requiring enzyme TPR_8 PF13181.6 ETO25920.1 - 0.56 10.6 7.5 0.46 10.8 3.9 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat BCDHK_Adom3 PF10436.9 ETO25922.1 - 3.3e-14 53.0 0.0 1.8e-13 50.6 0.0 2.2 3 0 0 3 3 3 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase HATPase_c PF02518.26 ETO25922.1 - 9.4e-11 42.2 0.0 1.5e-10 41.5 0.0 1.3 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase HATPase_c_3 PF13589.6 ETO25922.1 - 0.0039 17.0 0.0 0.0076 16.1 0.0 1.4 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase NACHT PF05729.12 ETO25923.1 - 3.3e-09 36.9 0.0 6.8e-09 35.9 0.0 1.6 1 0 0 1 1 1 1 NACHT domain WD40 PF00400.32 ETO25923.1 - 3.5e-08 34.0 0.3 3.2e-07 30.9 0.0 2.4 2 0 0 2 2 2 1 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO25923.1 - 0.0013 18.4 2.0 0.074 12.7 0.1 2.3 1 1 1 2 2 2 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO25923.1 - 0.0048 17.4 0.0 0.0048 17.4 0.0 2.8 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO25923.1 - 0.0057 16.9 0.0 0.017 15.4 0.0 1.9 1 0 0 1 1 1 1 AAA domain DUF809 PF05663.11 ETO25923.1 - 0.063 13.4 4.1 0.12 12.5 1.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF809) AAA PF00004.29 ETO25923.1 - 0.084 13.3 0.0 0.42 11.0 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) CbiA PF01656.23 ETO25923.1 - 0.83 9.7 3.3 3 7.9 0.0 2.8 2 1 0 2 2 2 0 CobQ/CobB/MinD/ParA nucleotide binding domain Arf PF00025.21 ETO25924.1 - 1.5e-20 73.3 0.0 1.7e-20 73.2 0.0 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family G-alpha PF00503.20 ETO25924.1 - 2.8e-09 36.6 0.9 0.00037 19.8 0.1 2.0 1 1 1 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ETO25924.1 - 1.5e-06 28.4 0.0 2.1e-06 28.0 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO25924.1 - 5.8e-05 23.1 0.0 6.4e-05 23.0 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase Ras PF00071.22 ETO25924.1 - 0.00012 21.7 0.0 0.00014 21.5 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ETO25924.1 - 0.0034 16.8 0.0 0.0038 16.6 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region FeoB_N PF02421.18 ETO25924.1 - 0.0049 16.4 0.0 0.0057 16.2 0.0 1.1 1 0 0 1 1 1 1 Ferrous iron transport protein B SRPRB PF09439.10 ETO25924.1 - 0.016 14.7 0.0 0.019 14.4 0.0 1.1 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 ETO25924.1 - 0.025 13.9 0.0 0.027 13.8 0.0 1.1 1 0 0 1 1 1 0 Septin AAA_29 PF13555.6 ETO25924.1 - 0.13 12.0 0.0 0.24 11.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain FtsK_SpoIIIE PF01580.18 ETO25924.1 - 0.14 11.5 0.0 0.18 11.1 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family Arf PF00025.21 ETO25925.1 - 8.3e-16 57.9 0.1 1.3e-15 57.3 0.1 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1_Xtn PF16897.5 ETO25925.1 - 0.076 13.0 0.4 0.16 12.0 0.0 1.7 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain SnoaL_2 PF12680.7 ETO25926.1 - 0.099 13.3 0.0 0.15 12.7 0.0 1.3 1 0 0 1 1 1 0 SnoaL-like domain MIP-T3_C PF17749.1 ETO25927.1 - 0.24 11.3 2.1 0.43 10.5 2.1 1.3 1 0 0 1 1 1 0 Microtubule-binding protein MIP-T3 C-terminal region Mito_carr PF00153.27 ETO25929.1 - 6e-45 151.1 0.9 2.9e-18 65.6 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3905 PF13045.6 ETO25929.1 - 0.0095 15.9 0.7 0.02 14.9 0.7 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3905) YtxH PF12732.7 ETO25929.1 - 0.51 10.9 1.4 2.7 8.6 0.0 2.6 2 1 1 3 3 3 0 YtxH-like protein RhoGAP PF00620.27 ETO25930.1 - 8.2e-20 71.2 0.2 1.1e-19 70.8 0.2 1.2 1 0 0 1 1 1 1 RhoGAP domain CCDC-167 PF15188.6 ETO25930.1 - 0.044 14.1 1.0 0.066 13.6 1.0 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 Med3 PF11593.8 ETO25931.1 - 0.0036 16.5 7.8 0.0036 16.5 7.8 3.0 3 0 0 3 3 3 1 Mediator complex subunit 3 fungal Sin3a_C PF16879.5 ETO25932.1 - 1.7e-07 31.3 10.9 1e-06 28.7 6.0 2.8 2 1 0 2 2 2 1 C-terminal domain of Sin3a protein DUF3746 PF12562.8 ETO25933.1 - 0.33 10.9 5.5 0.41 10.6 0.1 2.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3746) AAA PF00004.29 ETO25934.1 - 2.1e-13 50.8 0.0 3e-13 50.3 0.0 1.2 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO25934.1 - 2.8e-06 27.8 0.0 0.0001 22.8 0.0 2.3 1 1 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO25934.1 - 0.00022 21.5 0.0 0.00092 19.5 0.0 2.0 1 1 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETO25934.1 - 0.00035 20.4 0.0 0.00056 19.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein TniB PF05621.11 ETO25934.1 - 0.002 17.5 0.0 0.11 11.9 0.0 2.1 1 1 0 1 1 1 1 Bacterial TniB protein AAA_5 PF07728.14 ETO25934.1 - 0.0051 16.8 0.1 0.013 15.5 0.1 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_25 PF13481.6 ETO25934.1 - 0.0053 16.4 0.0 0.0088 15.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ETO25934.1 - 0.011 15.7 0.0 4.2 7.2 0.0 2.3 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea NACHT PF05729.12 ETO25934.1 - 0.028 14.3 0.0 0.047 13.6 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 ETO25934.1 - 0.029 13.9 0.0 0.12 11.8 0.0 2.0 1 1 1 2 2 2 0 P-loop containing dynein motor region DUF815 PF05673.13 ETO25934.1 - 0.045 12.9 0.1 0.16 11.1 0.1 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF815) RuvB_N PF05496.12 ETO25934.1 - 0.06 13.1 0.3 0.31 10.8 0.3 2.1 1 1 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 ETO25934.1 - 0.091 12.1 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO25934.1 - 0.092 12.5 0.0 0.15 11.8 0.0 1.5 1 1 0 1 1 1 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETO25934.1 - 0.18 12.2 0.0 0.46 10.9 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_18 PF13238.6 ETO25934.1 - 0.45 11.1 0.0 0.45 11.1 0.0 2.4 2 1 0 2 2 2 0 AAA domain Homoserine_dh PF00742.19 ETO25935.1 - 2.3e-29 102.5 0.0 3.6e-29 101.9 0.0 1.2 1 0 0 1 1 1 1 Homoserine dehydrogenase Gp_dh_N PF00044.24 ETO25935.1 - 0.059 13.7 1.6 0.87 10.0 0.1 2.9 2 1 1 3 3 3 0 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain Vps4_C PF09336.10 ETO25935.1 - 0.12 12.4 0.0 11 6.1 0.0 2.4 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain TLD PF07534.16 ETO25936.1 - 1e-17 64.7 1.4 1.8e-17 63.9 1.4 1.4 1 0 0 1 1 1 1 TLD Nop14 PF04147.12 ETO25936.1 - 0.022 13.0 48.0 0.036 12.3 48.0 1.3 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 ETO25937.1 - 0.042 12.4 20.5 0.046 12.3 20.5 1.0 1 0 0 1 1 1 0 Macoilin family LAP1C PF05609.12 ETO25937.1 - 0.08 12.0 11.9 0.083 12.0 11.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 ETO25937.1 - 0.16 10.2 13.7 0.16 10.2 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ETO25937.1 - 0.17 10.5 25.0 0.19 10.3 25.0 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Peptidase_S64 PF08192.11 ETO25937.1 - 0.31 9.5 16.2 0.31 9.5 16.2 1.1 1 0 0 1 1 1 0 Peptidase family S64 Utp14 PF04615.13 ETO25937.1 - 1 7.9 24.2 1.1 7.8 24.2 1.0 1 0 0 1 1 1 0 Utp14 protein DUF572 PF04502.13 ETO25937.1 - 1.1 8.9 19.3 1.2 8.7 19.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) PNISR PF15996.5 ETO25937.1 - 1.2 9.3 19.0 1.5 9.1 19.0 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SOG2 PF10428.9 ETO25937.1 - 1.7 7.7 15.4 2 7.5 15.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF2457 PF10446.9 ETO25937.1 - 5.1 6.1 18.5 7 5.7 18.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO25937.1 - 5.3 5.0 18.8 6.6 4.7 18.8 1.1 1 0 0 1 1 1 0 DNA polymerase phi Lin-8 PF03353.15 ETO25937.1 - 6.1 6.3 20.6 7.4 6.0 20.6 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist GREB1 PF15782.5 ETO25937.1 - 6.5 3.7 14.2 6.5 3.7 14.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer GDI PF00996.18 ETO25938.1 - 4.5e-15 55.1 0.9 1.1e-13 50.6 0.2 2.2 1 1 1 2 2 2 2 GDP dissociation inhibitor DUF3530 PF12048.8 ETO25938.1 - 0.017 14.5 2.2 0.68 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3530) DUF4087 PF13316.6 ETO25938.1 - 0.061 13.8 0.0 0.16 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF4087) BUD22 PF09073.10 ETO25938.1 - 0.59 9.4 13.9 2.4 7.4 6.5 2.0 2 0 0 2 2 2 0 BUD22 Peroxin-13_N PF04088.13 ETO25938.1 - 2.9 8.2 6.9 4.9 7.4 0.3 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Zip PF02535.22 ETO25938.1 - 5.1 6.2 7.4 0.83 8.8 0.9 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter NOA36 PF06524.12 ETO25938.1 - 5.8 6.1 20.0 18 4.5 0.1 2.0 2 0 0 2 2 2 0 NOA36 protein CRA PF06589.11 ETO25938.1 - 6.5 6.9 17.8 1 9.5 9.7 2.3 2 0 0 2 2 2 0 Circumsporozoite-related antigen (CRA) Ribosomal_L28e PF01778.17 ETO25939.1 - 0.008 16.9 1.9 0.024 15.4 1.9 1.8 1 0 0 1 1 1 1 Ribosomal L28e protein family V-ATPase_G_2 PF16999.5 ETO25940.1 - 0.21 12.0 3.8 0.45 11.0 0.1 2.2 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit XhlA PF10779.9 ETO25940.1 - 2.6 8.3 5.8 4.1 7.7 2.6 2.2 2 0 0 2 2 2 0 Haemolysin XhlA PDZ PF00595.24 ETO25941.1 - 0.0079 16.5 0.0 0.013 15.9 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO25941.1 - 0.097 12.5 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 PDZ domain ArfGap PF01412.18 ETO25943.1 - 9e-35 119.3 0.1 9e-35 119.3 0.1 2.7 3 0 0 3 3 3 1 Putative GTPase activating protein for Arf PH PF00169.29 ETO25943.1 - 7.8e-10 39.2 1.0 2.9e-09 37.4 0.2 2.3 2 0 0 2 2 2 1 PH domain BAR_3 PF16746.5 ETO25943.1 - 4.1e-07 30.0 4.8 1.8e-06 27.8 0.6 2.5 1 1 1 2 2 2 1 BAR domain of APPL family PH_11 PF15413.6 ETO25943.1 - 1.6e-06 28.5 0.3 1.6e-06 28.5 0.3 2.7 2 0 0 2 2 2 1 Pleckstrin homology domain Ank_2 PF12796.7 ETO25943.1 - 8.2e-06 26.3 0.0 2.2e-05 24.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO25943.1 - 0.00054 20.2 0.6 0.0032 17.8 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PH_8 PF15409.6 ETO25943.1 - 0.0016 18.7 0.1 0.0043 17.3 0.1 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain Ank PF00023.30 ETO25943.1 - 0.0025 18.2 0.2 0.023 15.1 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_3 PF13606.6 ETO25943.1 - 0.013 16.0 0.0 0.066 13.8 0.0 2.3 1 0 0 1 1 1 0 Ankyrin repeat T5orf172 PF10544.9 ETO25943.1 - 0.082 13.5 0.1 0.43 11.1 0.1 2.2 1 0 0 1 1 1 0 T5orf172 domain MRP-S24 PF14955.6 ETO25943.1 - 0.13 12.2 0.1 0.3 11.1 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial ribosome subunit S24 CDC27 PF09507.10 ETO25944.1 - 0.44 9.9 35.5 0.39 10.0 33.3 1.5 1 1 0 1 1 1 0 DNA polymerase subunit Cdc27 Med10 PF09748.9 ETO25946.1 - 1.5e-13 50.7 1.0 2.1e-13 50.3 0.6 1.4 1 1 0 1 1 1 1 Transcription factor subunit Med10 of Mediator complex TMF_TATA_bd PF12325.8 ETO25946.1 - 0.0065 16.7 3.5 0.011 15.9 3.5 1.4 1 0 0 1 1 1 1 TATA element modulatory factor 1 TATA binding PKI PF02827.16 ETO25946.1 - 0.8 10.0 3.1 3.2 8.0 0.0 2.5 3 0 0 3 3 3 0 cAMP-dependent protein kinase inhibitor Pro-kuma_activ PF09286.11 ETO25947.1 - 1.8e-21 76.9 0.7 4.2e-21 75.7 0.7 1.6 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain UNC-79 PF14776.6 ETO25947.1 - 0.023 13.5 2.0 0.03 13.1 2.0 1.2 1 0 0 1 1 1 0 Cation-channel complex subunit UNC-79 RICTOR_phospho PF14665.6 ETO25947.1 - 0.043 14.1 0.3 0.13 12.6 0.1 1.9 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, phosphorylation-site DUF2621 PF11084.8 ETO25948.1 - 0.095 12.7 0.1 0.18 11.7 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2621) TPR_1 PF00515.28 ETO25949.1 - 4.6e-21 73.7 15.0 0.00031 20.4 0.0 6.7 6 1 1 7 7 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO25949.1 - 1.8e-19 68.2 15.3 0.00045 20.1 0.0 7.1 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO25949.1 - 9.8e-19 66.8 11.4 9.5e-06 25.2 0.2 6.2 4 2 2 6 6 6 4 TPR repeat TPR_17 PF13431.6 ETO25949.1 - 2e-13 49.7 9.4 0.0053 17.0 0.2 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO25949.1 - 6.6e-13 49.1 2.0 0.00039 21.0 0.0 4.2 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO25949.1 - 6.6e-13 48.3 3.9 0.12 13.3 0.4 6.7 4 3 3 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO25949.1 - 9.2e-13 47.3 6.7 0.16 12.2 0.0 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETO25949.1 - 5.7e-08 33.2 2.9 0.0095 16.4 0.0 4.3 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO25949.1 - 1.1e-06 28.8 6.6 0.025 14.9 0.0 4.4 4 1 0 4 4 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO25949.1 - 3.4e-05 23.5 0.2 3.7 7.8 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO25949.1 - 0.00011 21.9 1.0 0.95 9.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO25949.1 - 0.0024 17.8 0.1 2.1 8.4 0.0 2.9 2 0 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO25949.1 - 0.0041 17.3 4.8 0.021 15.0 0.2 3.4 4 0 0 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_15 PF13429.6 ETO25949.1 - 0.0062 15.8 0.9 0.058 12.6 0.1 2.6 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO25949.1 - 0.018 15.4 0.9 11 6.4 0.0 3.7 2 1 2 4 4 4 0 Tetratricopeptide repeat DUF410 PF04190.13 ETO25949.1 - 0.033 14.0 0.0 0.1 12.4 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF410) TPR_6 PF13174.6 ETO25949.1 - 0.039 14.6 2.9 31 5.5 0.0 4.4 5 0 0 5 5 4 0 Tetratricopeptide repeat Coatomer_E PF04733.14 ETO25949.1 - 0.05 13.0 0.0 0.17 11.3 0.0 1.9 1 1 1 2 2 2 0 Coatomer epsilon subunit TPR_9 PF13371.6 ETO25949.1 - 0.12 12.6 1.8 5.7 7.2 0.0 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat MIT PF04212.18 ETO25949.1 - 0.84 9.8 3.2 43 4.3 0.1 3.9 4 1 0 4 4 3 0 MIT (microtubule interacting and transport) domain Acetyltransf_CG PF14542.6 ETO25950.1 - 7.1e-13 48.5 0.1 9.5e-13 48.1 0.1 1.2 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 ETO25950.1 - 0.00054 20.2 0.0 0.0017 18.6 0.0 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO25950.1 - 0.0014 18.6 0.2 0.004 17.1 0.1 1.7 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO25950.1 - 0.0025 17.7 0.0 0.0034 17.3 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_3 PF13302.7 ETO25950.1 - 0.0043 17.7 0.0 0.0051 17.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETO25950.1 - 0.014 15.5 0.0 0.066 13.3 0.0 1.9 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO25950.1 - 0.015 15.7 0.1 0.022 15.2 0.1 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain ABC2_membrane_3 PF12698.7 ETO25955.1 - 3.1e-14 52.8 34.1 1.1e-13 51.1 33.3 2.2 1 1 0 1 1 1 1 ABC-2 family transporter protein Myosin_head PF00063.21 ETO25957.1 - 6.8e-108 361.7 7.2 8.5e-108 361.4 7.2 1.1 1 0 0 1 1 1 1 Myosin head (motor domain) MAS20 PF02064.15 ETO25958.1 - 0.96 9.6 4.0 1.4 9.0 4.0 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor TMEM214 PF10151.9 ETO25958.1 - 1.9 6.9 7.7 2.4 6.5 7.7 1.2 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator DUF3464 PF11947.8 ETO25958.1 - 8 6.2 7.7 13 5.5 7.7 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 AP3D1 PF06375.11 ETO25958.1 - 9.7 6.4 16.1 9.4 6.5 15.4 1.3 1 1 0 1 1 1 0 AP-3 complex subunit delta-1 GREB1 PF15782.5 ETO25959.1 - 0.045 10.9 11.0 0.061 10.4 11.0 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF2140 PF09911.9 ETO25959.1 - 9.4 5.7 8.2 15 5.1 7.3 1.8 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2140) HgmA PF04209.13 ETO25960.1 - 1.2e-67 228.5 0.1 1.7e-39 135.7 0.1 2.0 1 1 1 2 2 2 2 homogentisate 1,2-dioxygenase DUF11 PF01345.18 ETO25962.1 - 0.37 11.1 8.0 0.36 11.2 3.6 2.7 2 1 0 2 2 2 0 Domain of unknown function DUF11 PUF PF00806.19 ETO25963.1 - 2.3e-18 64.8 2.0 8.1e-05 22.1 0.0 5.6 5 0 0 5 5 5 3 Pumilio-family RNA binding repeat CPL PF08144.11 ETO25963.1 - 0.00011 22.5 1.6 3.6 7.9 0.1 4.4 2 2 2 4 4 4 2 CPL (NUC119) domain HNOB PF07700.15 ETO25963.1 - 0.021 14.8 1.9 7.4 6.5 0.0 3.8 2 2 2 4 4 4 0 Haem-NO-binding PepX_C PF08530.10 ETO25964.1 - 3.3e-29 102.4 0.0 5.6e-29 101.7 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain Peptidase_S15 PF02129.18 ETO25964.1 - 6.6e-11 42.3 9.1 1.3e-08 34.8 1.6 2.2 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Mob1_phocein PF03637.17 ETO25965.1 - 5.7e-29 101.3 1.5 1e-15 58.1 0.1 2.2 2 0 0 2 2 2 2 Mob1/phocein family CD34_antigen PF06365.12 ETO25967.1 - 0.014 15.0 0.0 0.027 14.0 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family Adeno_E3_CR2 PF02439.15 ETO25967.1 - 4.4 7.1 10.1 0.55 10.0 5.3 1.8 2 0 0 2 2 2 0 Adenovirus E3 region protein CR2 TPR_14 PF13428.6 ETO25968.1 - 1.5e-05 25.4 1.1 1.6 9.8 0.0 4.5 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO25968.1 - 0.00058 20.3 0.9 0.31 11.6 0.2 3.4 3 2 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO25968.1 - 0.014 16.0 0.0 12 6.6 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO25968.1 - 0.046 13.9 7.3 0.1 12.9 0.1 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO25968.1 - 0.069 13.3 13.3 1.9 8.8 0.1 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO25968.1 - 0.1 12.5 8.9 0.29 11.0 0.4 3.9 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO25968.1 - 0.23 11.8 11.9 2.3 8.5 0.4 4.9 4 2 1 5 5 5 0 Tetratricopeptide repeat Dapper PF15268.6 ETO25968.1 - 0.57 9.0 15.0 0.022 13.6 8.8 1.7 2 0 0 2 2 2 0 Dapper STPPase_N PF16891.5 ETO25970.1 - 9.2e-17 61.2 1.5 1.3e-16 60.8 1.5 1.2 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Metallophos PF00149.28 ETO25970.1 - 0.091 13.2 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase WD40 PF00400.32 ETO25971.1 - 8.7e-29 99.2 16.5 4.1e-07 30.6 0.4 6.0 5 0 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO25971.1 - 2e-10 39.9 3.5 0.0014 17.4 0.5 4.9 2 2 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO25971.1 - 2.8e-05 24.3 0.1 1.4 9.2 0.0 4.9 4 1 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO25971.1 - 0.11 12.5 0.5 37 4.4 0.0 3.8 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region HSP20 PF00011.21 ETO25972.1 - 0.13 12.5 0.0 0.48 10.6 0.0 1.9 2 0 0 2 2 2 0 Hsp20/alpha crystallin family WD40 PF00400.32 ETO25973.1 - 1.5e-55 183.9 24.5 2.9e-10 40.5 0.1 7.7 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25973.1 - 9.4e-24 83.5 2.3 0.0011 19.2 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO25973.1 - 2.9e-12 46.5 0.6 5.2e-06 26.0 1.4 3.8 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETO25973.1 - 1.3e-10 40.8 0.4 0.066 12.2 0.0 5.8 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO25973.1 - 4.4e-08 32.1 1.8 0.0031 16.1 0.2 3.7 1 1 3 4 4 4 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO25973.1 - 5.8e-06 25.2 2.1 0.18 10.4 0.0 5.4 2 1 2 4 4 4 1 Nucleoporin Nup120/160 PD40 PF07676.12 ETO25973.1 - 2.5e-05 24.1 4.8 5.1 7.2 0.0 5.9 7 0 0 7 7 6 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO25973.1 - 0.00014 21.0 0.3 0.0069 15.5 0.1 2.7 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain BBS2_Mid PF14783.6 ETO25973.1 - 0.00057 19.9 0.9 13 5.8 0.0 4.9 4 2 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Kelch_6 PF13964.6 ETO25973.1 - 0.0028 17.9 3.3 3.8 7.9 0.3 4.7 4 0 0 4 4 4 1 Kelch motif PQQ_2 PF13360.6 ETO25973.1 - 0.007 16.0 0.1 0.7 9.4 0.0 2.9 1 1 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 ETO25973.1 - 0.01 15.7 0.0 28 4.9 0.0 4.7 6 0 0 6 6 6 0 PQQ enzyme repeat DUF1513 PF07433.11 ETO25973.1 - 0.022 13.9 0.1 3.4 6.7 0.0 3.0 2 1 0 3 3 3 0 Protein of unknown function (DUF1513) PALB2_WD40 PF16756.5 ETO25973.1 - 0.06 12.3 2.4 6.6 5.5 0.0 3.5 3 2 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain Kelch_1 PF01344.25 ETO25973.1 - 0.14 11.8 0.4 0.38 10.4 0.4 1.8 1 0 0 1 1 1 0 Kelch motif nos_propeller PF18764.1 ETO25973.1 - 0.14 12.1 0.0 15 5.6 0.0 3.1 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat Kelch_4 PF13418.6 ETO25973.1 - 0.34 11.0 1.4 1.8 8.7 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Proteasome_A_N PF10584.9 ETO25973.1 - 0.64 9.7 2.9 64 3.4 0.1 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature CH PF00307.31 ETO25974.1 - 0.029 14.5 0.0 0.56 10.4 0.0 2.5 2 0 0 2 2 2 0 Calponin homology (CH) domain WD40 PF00400.32 ETO25975.1 - 8.9e-06 26.4 0.8 0.039 14.8 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25975.1 - 0.00046 20.4 0.0 0.07 13.4 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO25975.1 - 0.051 12.5 0.1 0.73 8.7 0.0 2.0 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CH PF00307.31 ETO25976.1 - 7.2e-23 80.9 0.0 3.5e-13 49.7 0.0 2.2 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO25976.1 - 3.3e-05 23.6 0.0 7.4e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 CAMSAP CH domain zf-C3HC4_3 PF13920.6 ETO25977.1 - 2.5e-05 24.0 2.7 2.5e-05 24.0 2.7 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO25977.1 - 0.00024 21.1 5.1 0.00053 19.9 5.1 1.6 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO25977.1 - 0.00025 20.8 5.6 0.00025 20.8 5.6 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) UBA PF00627.31 ETO25977.1 - 0.00086 19.2 0.0 0.0021 18.0 0.0 1.6 1 0 0 1 1 1 1 UBA/TS-N domain zf-RING_2 PF13639.6 ETO25977.1 - 0.0018 18.6 3.4 0.0018 18.6 3.4 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO25977.1 - 0.0077 16.1 3.9 0.0077 16.1 3.9 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO25977.1 - 0.0092 15.9 4.9 0.0092 15.9 4.9 2.1 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETO25977.1 - 0.11 12.2 3.5 0.34 10.7 3.5 1.9 1 0 0 1 1 1 0 RING-like zinc finger Prok-RING_4 PF14447.6 ETO25977.1 - 4.2 7.3 7.3 0.29 11.0 2.2 1.7 2 0 0 2 2 2 0 Prokaryotic RING finger family 4 PI3Ka PF00613.20 ETO25978.1 - 3.3e-50 170.1 1.4 1.1e-49 168.3 1.9 1.6 2 0 0 2 2 2 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETO25978.1 - 7e-14 52.2 0.2 2.5e-11 43.9 0.0 2.6 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase Utp13 PF08625.11 ETO25979.1 - 1e-40 138.9 0.8 2.4e-40 137.7 0.8 1.7 1 0 0 1 1 1 1 Utp13 specific WD40 associated domain WD40 PF00400.32 ETO25979.1 - 3.1e-25 87.9 20.1 2e-06 28.4 0.9 8.6 8 0 0 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO25979.1 - 1.9e-05 24.8 2.9 0.053 13.8 0.0 4.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain His_Phos_2 PF00328.22 ETO25980.1 - 0.019 14.3 0.0 0.026 13.9 0.0 1.3 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 2) CAP_GLY PF01302.25 ETO25981.1 - 8.8e-13 48.1 0.6 1.4e-12 47.4 0.6 1.3 1 0 0 1 1 1 1 CAP-Gly domain CH PF00307.31 ETO25983.1 - 1.8e-06 28.1 0.7 0.004 17.3 0.0 3.5 2 1 0 2 2 2 2 Calponin homology (CH) domain Striatin PF08232.12 ETO25983.1 - 0.0022 18.6 2.7 0.0043 17.7 2.7 1.4 1 0 0 1 1 1 1 Striatin family CH PF00307.31 ETO25984.1 - 3.6e-29 101.1 1.0 2.3e-19 69.5 0.3 2.4 2 0 0 2 2 2 2 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO25984.1 - 1.3e-07 31.3 0.3 4.2e-07 29.7 0.1 2.0 2 0 0 2 2 2 1 CAMSAP CH domain CH_2 PF06294.11 ETO25984.1 - 3.3e-06 27.1 0.1 7.7e-06 25.9 0.1 1.7 1 0 0 1 1 1 1 CH-like domain in sperm protein Ras_bdg_2 PF14847.6 ETO25985.1 - 0.16 12.3 1.2 0.44 10.9 0.2 2.3 2 0 0 2 2 2 0 Ras-binding domain of Byr2 Thioredoxin_16 PF18569.1 ETO25985.1 - 0.21 11.7 1.7 0.44 10.7 0.1 2.5 2 0 0 2 2 2 0 Thioredoxin-like domain DUF2153 PF09921.9 ETO25986.1 - 0.035 13.9 0.0 0.1 12.4 0.0 1.8 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2153) Secretin_N_2 PF07655.13 ETO25986.1 - 0.081 13.5 7.9 2.5 8.7 0.1 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain MDFI PF15316.6 ETO25986.1 - 0.32 11.1 9.8 6 6.9 5.8 2.6 3 0 0 3 3 3 0 MyoD family inhibitor DUF4692 PF15763.5 ETO25986.1 - 0.75 10.2 5.9 1.9 8.9 5.9 1.7 1 0 0 1 1 1 0 Regulator of human erythroid cell expansion (RHEX) Presenilin PF01080.17 ETO25986.1 - 8.6 5.0 9.4 0.4 9.4 3.8 1.6 2 0 0 2 2 2 0 Presenilin GTP_EFTU PF00009.27 ETO25987.1 - 2e-05 24.2 0.1 0.0021 17.7 0.1 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1_Xtn PF16897.5 ETO25987.1 - 0.00021 21.3 1.1 0.00088 19.3 1.1 2.0 1 1 0 1 1 1 1 C-terminal region of MMR_HSR1 domain SUKH_5 PF14567.6 ETO25987.1 - 0.012 15.3 0.0 0.016 15.0 0.0 1.2 1 0 0 1 1 1 0 SMI1-KNR4 cell-wall SpoIISA_toxin PF14171.6 ETO25987.1 - 0.046 13.4 0.2 0.049 13.3 0.2 1.1 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system DUF4580 PF15162.6 ETO25987.1 - 0.055 13.1 0.2 0.075 12.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4580) eIF2_C PF09173.11 ETO25988.1 - 1.7e-07 31.4 0.2 5.1e-05 23.4 0.1 2.4 2 0 0 2 2 2 2 Initiation factor eIF2 gamma, C terminal GTP_EFTU_D2 PF03144.25 ETO25988.1 - 1.1e-06 28.9 0.4 2.6e-06 27.7 0.4 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 RRM_1 PF00076.22 ETO25989.1 - 6.6e-07 29.1 0.0 1.1e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2681 PF10883.8 ETO25989.1 - 0.36 11.3 7.7 0.93 9.9 6.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) CorA PF01544.18 ETO25990.1 - 3.8e-10 39.6 0.1 6.2e-10 38.9 0.1 1.2 1 0 0 1 1 1 1 CorA-like Mg2+ transporter protein PrmA PF06325.13 ETO25992.1 - 0.058 12.8 0.1 0.068 12.6 0.1 1.2 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) DUF2408 PF10303.9 ETO25992.1 - 0.059 13.9 4.1 0.12 12.9 4.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2408) ApoLp-III PF07464.11 ETO25992.1 - 0.43 10.7 7.5 0.8 9.8 7.5 1.6 1 1 0 1 1 1 0 Apolipophorin-III precursor (apoLp-III) DUF948 PF06103.11 ETO25992.1 - 0.44 10.8 2.4 3.1 8.1 0.5 2.5 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.15 ETO25992.1 - 1.2 8.6 4.1 1.6 8.3 4.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 ETO25992.1 - 1.8 9.1 7.7 1.7 9.2 2.5 2.5 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein TRPM_tetra PF16519.5 ETO25992.1 - 3 8.0 6.7 1.1 9.4 1.8 2.5 2 1 1 3 3 3 0 Tetramerisation domain of TRPM BLOC1_2 PF10046.9 ETO25992.1 - 3.1 8.1 7.9 1.4 9.3 2.1 2.6 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Phage_GP20 PF06810.11 ETO25992.1 - 4.4 7.1 7.3 1 9.2 3.3 1.9 1 1 1 2 2 2 0 Phage minor structural protein GP20 ANAPC2 PF08672.11 ETO25992.1 - 5.3 7.6 7.1 28 5.3 0.0 3.0 3 1 1 4 4 4 0 Anaphase promoting complex (APC) subunit 2 EF-G-binding_N PF07299.11 ETO25993.1 - 0.014 15.9 3.9 0.14 12.7 2.2 2.3 2 0 0 2 2 2 0 Elongation factor G-binding protein, N-terminal SAM_PNT PF02198.16 ETO25993.1 - 0.046 13.7 0.1 0.099 12.6 0.1 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Lipoprotein_3 PF00938.17 ETO25994.1 - 0.094 12.9 0.3 56 4.0 0.0 3.2 3 0 0 3 3 3 0 Lipoprotein NAD_binding_6 PF08030.12 ETO25996.1 - 2.2 8.4 10.1 8.8 6.4 0.5 2.2 2 0 0 2 2 2 0 Ferric reductase NAD binding domain Calcyon PF06387.11 ETO25997.1 - 5.3e-05 23.3 1.1 8.4e-05 22.6 0.5 1.5 1 1 0 1 1 1 1 D1 dopamine receptor-interacting protein (calcyon) Shisa PF13908.6 ETO25997.1 - 0.0013 19.0 3.3 0.0019 18.5 3.3 1.2 1 0 0 1 1 1 1 Wnt and FGF inhibitory regulator FtsL PF04999.13 ETO25997.1 - 0.0064 16.5 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Cell division protein FtsL TMEM154 PF15102.6 ETO25997.1 - 0.0097 15.8 2.1 0.018 15.0 1.8 1.7 1 1 0 1 1 1 1 TMEM154 protein family Amnionless PF14828.6 ETO25997.1 - 0.01 14.7 0.3 0.012 14.4 0.3 1.1 1 0 0 1 1 1 0 Amnionless 7TM_GPCR_Srd PF10317.9 ETO25997.1 - 0.012 14.9 0.6 0.016 14.4 0.6 1.1 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd Ctr PF04145.15 ETO25997.1 - 0.018 15.7 1.9 0.038 14.6 0.0 2.0 1 1 1 2 2 2 0 Ctr copper transporter family LapA_dom PF06305.11 ETO25997.1 - 0.043 13.6 1.8 0.066 13.0 0.1 2.2 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain Orf78 PF06024.12 ETO25997.1 - 0.046 14.0 1.4 0.046 14.0 1.4 1.9 1 1 1 2 2 2 0 Orf78 (ac78) UL45 PF05473.12 ETO25997.1 - 0.047 13.3 0.1 0.079 12.6 0.1 1.3 1 0 0 1 1 1 0 UL45 protein, carbohydrate-binding C-type lectin-like Cyt_b-c1_8 PF10890.8 ETO25997.1 - 0.052 13.9 0.2 3.3 8.2 0.0 2.5 2 0 0 2 2 2 0 Cytochrome b-c1 complex subunit 8 DUF1938 PF09153.10 ETO25997.1 - 0.1 12.7 1.2 1.2 9.3 0.3 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF1938) DUF2371 PF10177.9 ETO25997.1 - 0.27 11.4 2.9 0.98 9.6 2.8 1.9 1 1 1 2 2 2 0 Uncharacterised conserved protein (DUF2371) AP3D1 PF06375.11 ETO25997.1 - 0.48 10.6 4.6 9.5 6.4 0.2 2.2 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 DUF4834 PF16118.5 ETO25997.1 - 1.5 9.8 6.9 0.62 11.1 0.5 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) Zip PF02535.22 ETO25997.1 - 1.6 7.9 5.2 2.3 7.4 0.2 2.1 1 1 0 2 2 2 0 ZIP Zinc transporter Comm PF15957.5 ETO25997.1 - 6.2 7.2 7.1 0.79 10.1 2.1 2.0 1 1 1 2 2 2 0 Commissureless Zip PF02535.22 ETO25998.1 - 0.021 14.1 1.9 0.024 13.9 1.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FGF-BP1 PF06473.12 ETO25998.1 - 0.03 14.2 6.8 0.047 13.5 6.8 1.4 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Presenilin PF01080.17 ETO25998.1 - 0.047 12.4 3.5 0.055 12.2 3.5 1.1 1 0 0 1 1 1 0 Presenilin DUF262 PF03235.14 ETO25998.1 - 0.069 13.3 3.4 0.085 13.0 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function DUF262 RP-C_C PF11800.8 ETO25998.1 - 0.12 12.4 1.8 0.15 12.2 1.8 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Fanconi_A PF03511.14 ETO25998.1 - 0.14 12.1 0.0 0.38 10.7 0.0 1.7 2 0 0 2 2 2 0 Fanconi anaemia group A protein CDC27 PF09507.10 ETO25998.1 - 0.24 10.8 19.2 0.33 10.3 19.2 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CBP_BcsG PF11658.8 ETO25998.1 - 0.4 9.0 3.4 0.23 9.8 1.7 1.4 1 1 1 2 2 2 0 Cellulose biosynthesis protein BcsG SURF2 PF05477.11 ETO25998.1 - 0.52 10.0 17.3 0.76 9.4 17.3 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DUF4770 PF15994.5 ETO25998.1 - 0.53 10.5 7.8 0.73 10.0 7.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) CLN3 PF02487.17 ETO25998.1 - 0.81 8.7 3.9 1.1 8.2 3.9 1.3 1 1 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 ETO25998.1 - 1.1 9.0 12.5 1.6 8.5 12.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Sec62 PF03839.16 ETO25998.1 - 1.6 8.2 12.3 2.2 7.7 12.3 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 OAD_gamma PF04277.13 ETO25998.1 - 3.8 8.2 18.2 0.16 12.6 1.8 2.3 1 1 1 2 2 2 0 Oxaloacetate decarboxylase, gamma chain YMF19 PF02326.15 ETO25998.1 - 4.3 8.2 6.1 1.2 10.0 0.3 2.1 1 1 1 2 2 2 0 Plant ATP synthase F0 CDC45 PF02724.14 ETO25998.1 - 5 5.3 13.8 5.9 5.1 13.8 1.0 1 0 0 1 1 1 0 CDC45-like protein PEX11 PF05648.14 ETO25998.1 - 6.3 6.2 7.9 1.1 8.7 0.4 2.0 1 1 1 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) Tim54 PF11711.8 ETO25998.1 - 8.3 5.1 13.2 11 4.7 13.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 YhfZ_C PF14503.6 ETO25999.1 - 0.065 12.8 0.0 0.087 12.3 0.0 1.3 1 0 0 1 1 1 0 YhfZ C-terminal domain Thioredoxin PF00085.20 ETO26000.1 - 3.6e-23 81.5 0.2 4.6e-23 81.2 0.2 1.1 1 0 0 1 1 1 1 Thioredoxin Thioredoxin_8 PF13905.6 ETO26000.1 - 0.028 14.7 0.0 0.097 13.0 0.0 1.8 1 1 0 1 1 1 0 Thioredoxin-like Thioredoxin_9 PF14595.6 ETO26000.1 - 0.04 13.7 0.0 0.049 13.4 0.0 1.1 1 0 0 1 1 1 0 Thioredoxin Mucin PF01456.17 ETO26001.1 - 2.2 8.3 48.1 4.1 7.4 48.1 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein CENP-B_dimeris PF09026.10 ETO26002.1 - 4.6 7.7 12.9 33 4.9 0.0 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DnaJ PF00226.31 ETO26003.1 - 0.0041 17.2 0.2 0.012 15.7 0.0 1.9 2 1 0 2 2 2 1 DnaJ domain Bcl-2_3 PF15286.6 ETO26003.1 - 0.044 14.4 0.0 0.053 14.2 0.0 1.2 1 0 0 1 1 1 0 Apoptosis regulator M11, B cell 2 leukaemia/lymphoma like N_Asn_amidohyd PF14736.6 ETO26004.1 - 2.3e-14 53.2 0.5 3e-14 52.8 0.5 1.1 1 0 0 1 1 1 1 Protein N-terminal asparagine amidohydrolase DUF2634 PF10934.8 ETO26004.1 - 0.079 13.1 1.7 8.7 6.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2634) CCDC50_N PF15295.6 ETO26005.1 - 0.034 14.3 2.0 0.073 13.2 2.0 1.5 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 50 N-terminus TMEM191C PF15194.6 ETO26007.1 - 0.059 13.6 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 TMEM191C family Vicilin_N PF04702.12 ETO26007.1 - 3.5 7.5 15.7 0.4 10.5 3.9 2.5 3 0 0 3 3 3 0 Vicilin N terminal region Vmethyltransf_C PF08456.10 ETO26008.1 - 0.015 14.8 0.4 0.034 13.7 0.4 1.5 1 0 0 1 1 1 0 Viral methyltransferase C-terminal Prenylcys_lyase PF07156.14 ETO26010.1 - 3.8e-16 59.1 0.1 5.6e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 Prenylcysteine lyase Pkinase PF00069.25 ETO26011.1 - 9.5e-24 84.2 0.2 2.1e-15 56.8 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Kdo PF06293.14 ETO26011.1 - 0.0043 16.4 0.0 0.0071 15.7 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_Tyr PF07714.17 ETO26011.1 - 0.0068 15.7 0.0 0.012 14.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO26011.1 - 0.0071 15.2 0.0 0.011 14.6 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Ntox16 PF15523.6 ETO26011.1 - 0.084 13.1 0.4 0.16 12.2 0.1 1.6 2 0 0 2 2 2 0 Novel toxin 16 APH PF01636.23 ETO26011.1 - 0.18 11.7 0.0 0.29 11.0 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family BING4CT PF08149.11 ETO26012.1 - 1.2e-34 117.9 0.1 2e-33 114.0 0.0 2.9 3 0 0 3 3 3 1 BING4CT (NUC141) domain WD40 PF00400.32 ETO26012.1 - 0.09 13.7 1.1 32 5.6 0.0 4.5 5 0 0 5 5 5 0 WD domain, G-beta repeat DAG_kinase_N PF14513.6 ETO26013.1 - 0.1 12.8 2.1 1.9 8.7 0.2 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus WD40 PF00400.32 ETO26014.1 - 2.3e-39 132.7 23.4 1.8e-06 28.6 0.6 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO26014.1 - 4.6e-10 38.8 4.0 0.0044 15.7 0.1 5.1 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO26014.1 - 4.4e-09 36.5 2.5 0.52 10.6 0.0 5.6 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Osteopontin PF00865.18 ETO26015.1 - 0.84 9.1 16.8 1.8 8.0 16.8 1.4 1 0 0 1 1 1 0 Osteopontin ACDC PF14733.6 ETO26016.1 - 0.053 13.8 1.0 0.15 12.4 1.0 1.9 1 0 0 1 1 1 0 AP2-coincident C-terminal PALP PF00291.25 ETO26017.1 - 0.018 14.5 0.0 0.024 14.1 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-phosphate dependent enzyme Pro_sub2 PF18513.1 ETO26017.1 - 0.052 13.7 0.3 5.8 7.2 0.0 2.6 2 0 0 2 2 2 0 Prodomain subtilisin 2 TruB_C_2 PF16198.5 ETO26018.1 - 5.5e-21 74.5 1.4 1.1e-20 73.5 1.4 1.6 1 0 0 1 1 1 1 tRNA pseudouridylate synthase B C-terminal domain TruB_N PF01509.18 ETO26018.1 - 2.4e-18 66.9 9.1 1.7e-16 61.0 0.2 4.6 3 1 0 3 3 3 1 TruB family pseudouridylate synthase (N terminal domain) PUA PF01472.20 ETO26018.1 - 4.1e-17 61.9 1.4 4.1e-17 61.9 1.4 1.7 2 0 0 2 2 2 1 PUA domain DKCLD PF08068.12 ETO26018.1 - 6.2e-10 39.0 0.2 2.3e-07 30.8 0.1 3.5 3 0 0 3 3 3 1 DKCLD (NUC011) domain UPF0113 PF03657.13 ETO26018.1 - 0.072 13.4 0.0 0.24 11.7 0.0 1.9 1 0 0 1 1 1 0 UPF0113 PUA domain Beta_helix PF13229.6 ETO26019.1 - 0.0003 20.7 7.4 0.0003 20.7 7.4 2.4 2 1 0 2 2 2 1 Right handed beta helix region PBP1_TM PF14812.6 ETO26020.1 - 0.83 10.1 8.4 0.073 13.5 1.9 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal cwf18 PF08315.12 ETO26021.1 - 4.1e-17 63.1 8.0 4.1e-17 63.1 8.0 2.1 1 1 1 2 2 2 1 cwf18 pre-mRNA splicing factor Pox_A31 PF05771.11 ETO26021.1 - 0.019 15.0 0.3 0.032 14.2 0.3 1.3 1 0 0 1 1 1 0 Poxvirus A31 protein CH PF00307.31 ETO26021.1 - 0.041 14.1 0.9 0.066 13.4 0.4 1.8 1 1 0 1 1 1 0 Calponin homology (CH) domain NARP1 PF12569.8 ETO26022.1 - 0.015 14.2 22.6 0.02 13.8 22.6 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CDC45 PF02724.14 ETO26022.1 - 0.12 10.6 24.7 0.13 10.5 24.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Caldesmon PF02029.15 ETO26022.1 - 0.37 9.5 36.7 0.47 9.1 36.7 1.1 1 0 0 1 1 1 0 Caldesmon RR_TM4-6 PF06459.12 ETO26022.1 - 0.45 10.3 26.1 0.67 9.7 26.1 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO26022.1 - 0.65 8.7 20.6 0.68 8.6 20.6 1.1 1 0 0 1 1 1 0 Presenilin MMR1 PF08505.10 ETO26022.1 - 0.66 10.2 21.4 0.77 10.0 21.4 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein SOBP PF15279.6 ETO26022.1 - 0.81 10.2 14.2 0.89 10.1 14.2 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein AAA_11 PF13086.6 ETO26022.1 - 0.92 9.2 22.8 1.1 9.0 22.8 1.2 1 0 0 1 1 1 0 AAA domain Ndc1_Nup PF09531.10 ETO26022.1 - 0.95 8.1 9.4 1 8.0 9.4 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup DUF572 PF04502.13 ETO26022.1 - 1.2 8.7 30.3 1.7 8.2 30.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) Astro_capsid_N PF03115.14 ETO26022.1 - 1.4 7.5 8.0 1.7 7.2 8.0 1.1 1 0 0 1 1 1 0 Astrovirus capsid protein precursor TP53IP5 PF15331.6 ETO26022.1 - 1.6 8.9 23.6 1.8 8.6 23.6 1.1 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Neur_chan_memb PF02932.16 ETO26022.1 - 2 8.4 11.4 2.7 8.0 11.4 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4407 PF14362.6 ETO26022.1 - 3.1 7.1 13.6 3.9 6.8 13.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF262 PF03235.14 ETO26022.1 - 4.3 7.4 15.0 5.6 7.1 15.0 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF262 NCKAP5 PF15246.6 ETO26022.1 - 4.3 6.8 39.9 0.27 10.8 33.7 1.8 1 1 1 2 2 2 0 Nck-associated protein 5, Peripheral clock protein Asp-B-Hydro_N PF05279.11 ETO26022.1 - 5.3 7.0 23.7 6.1 6.8 23.7 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF936 PF06075.12 ETO26022.1 - 6.4 5.6 24.8 6.8 5.5 24.8 1.1 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) SLC12 PF03522.15 ETO26022.1 - 7.3 5.5 22.9 8.9 5.2 22.9 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Membralin PF09746.9 ETO26022.1 - 8.6 5.3 12.5 11 5.0 12.5 1.3 1 0 0 1 1 1 0 Tumour-associated protein Hid1 PF12722.7 ETO26022.1 - 9.7 4.2 20.0 10 4.1 20.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Macro PF01661.21 ETO26024.1 - 5.4e-26 91.0 0.0 1e-25 90.1 0.0 1.5 1 0 0 1 1 1 1 Macro domain Endonuclease_5 PF04493.14 ETO26024.1 - 0.041 13.6 0.0 0.064 12.9 0.0 1.2 1 0 0 1 1 1 0 Endonuclease V WD40 PF00400.32 ETO26025.1 - 1.1e-09 38.7 2.9 0.0011 19.8 0.2 3.9 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26025.1 - 0.00097 19.4 0.1 0.86 10.0 0.0 3.4 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO26025.1 - 0.08 11.6 0.0 0.13 10.9 0.0 1.4 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Ion_trans PF00520.31 ETO26027.1 - 3.8e-35 121.3 21.7 1.6e-26 93.0 8.3 2.5 2 1 0 2 2 2 2 Ion transport protein DUF2207 PF09972.9 ETO26028.1 - 0.067 11.9 0.5 0.072 11.8 0.5 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Herpes_LMP1 PF05297.11 ETO26028.1 - 0.071 12.3 1.1 0.074 12.2 1.1 1.1 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Nairovirus_M PF07948.11 ETO26028.1 - 0.16 10.2 4.2 0.17 10.1 4.2 1.1 1 0 0 1 1 1 0 Nairovirus M polyprotein-like Orf78 PF06024.12 ETO26028.1 - 1.7 9.0 6.6 2.5 8.5 6.6 1.4 1 1 0 1 1 1 0 Orf78 (ac78) Ion_trans PF00520.31 ETO26029.1 - 5.8e-17 61.7 10.4 8.4e-17 61.2 10.4 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO26029.1 - 6.2e-06 25.1 7.0 9e-06 24.6 7.0 1.2 1 0 0 1 1 1 1 Polycystin cation channel GPHH PF16905.5 ETO26029.1 - 0.0018 18.0 0.0 0.0045 16.7 0.0 1.7 1 0 0 1 1 1 1 Voltage-dependent L-type calcium channel, IQ-associated Hum_adeno_E3A PF05393.11 ETO26031.1 - 0.12 12.3 3.5 0.81 9.7 0.0 4.6 2 0 0 2 2 2 0 Human adenovirus early E3A glycoprotein DUF3938 PF13074.6 ETO26032.1 - 0.0015 18.7 0.0 0.0036 17.5 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF3938) LIP PF03583.14 ETO26032.1 - 0.12 11.7 0.4 0.21 10.9 0.4 1.3 1 0 0 1 1 1 0 Secretory lipase DUF2098 PF09871.9 ETO26032.1 - 2.2 8.7 4.4 0.92 9.9 0.1 2.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2098) MFS_1 PF07690.16 ETO26033.1 - 4.1e-06 26.0 0.0 5.1e-06 25.7 0.0 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily MASE1 PF05231.14 ETO26033.1 - 0.0018 17.5 0.4 0.0022 17.2 0.4 1.2 1 0 0 1 1 1 1 MASE1 Bac_A_amyl_C PF18612.1 ETO26033.1 - 0.0074 16.0 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Bacterial Alpha amylase C-terminal domain SNARE_assoc PF09335.11 ETO26033.1 - 0.011 16.3 0.4 0.025 15.1 0.3 1.6 1 1 0 1 1 1 0 SNARE associated Golgi protein LapA_dom PF06305.11 ETO26033.1 - 0.033 14.0 3.2 0.033 14.0 3.2 2.2 2 1 1 3 3 3 0 Lipopolysaccharide assembly protein A domain IFNGR1 PF07140.11 ETO26033.1 - 0.045 13.9 0.4 0.056 13.5 0.4 1.3 1 0 0 1 1 1 0 Interferon gamma receptor (IFNGR1) ThrE PF06738.12 ETO26033.1 - 0.082 12.3 0.3 0.082 12.3 0.3 1.4 2 0 0 2 2 2 0 Putative threonine/serine exporter PepSY_TM_like_2 PF16357.5 ETO26033.1 - 0.17 11.8 2.8 0.31 11.0 2.8 1.4 1 0 0 1 1 1 0 Putative PepSY_TM-like FAM176 PF14851.6 ETO26033.1 - 0.38 10.4 0.0 0.38 10.4 0.0 1.7 2 0 0 2 2 2 0 FAM176 family Vpu PF00558.19 ETO26033.1 - 0.75 9.6 4.7 2.9 7.7 4.7 1.9 1 1 0 1 1 1 0 Vpu protein Wzy_C PF04932.15 ETO26033.1 - 0.82 9.3 8.4 8.8 5.9 8.4 2.0 1 1 0 1 1 1 0 O-Antigen ligase Destabilase PF05497.12 ETO26034.1 - 1.7e-05 25.1 0.2 2.9e-05 24.4 0.2 1.4 1 0 0 1 1 1 1 Destabilase TFIIA PF03153.13 ETO26034.1 - 0.11 12.5 14.3 0.11 12.5 14.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit RP-C_C PF11800.8 ETO26034.1 - 2.2 8.3 6.8 3 7.9 6.8 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 ETO26034.1 - 5.4 5.7 9.3 5.6 5.6 9.3 1.1 1 0 0 1 1 1 0 Presenilin RTP801_C PF07809.11 ETO26035.1 - 0.022 14.7 0.8 0.043 13.7 0.8 1.5 1 0 0 1 1 1 0 RTP801 C-terminal region DUF1829 PF08862.10 ETO26035.1 - 0.089 13.3 1.7 0.31 11.5 1.7 1.9 1 0 0 1 1 1 0 Domain of unknown function DUF1829 Amidohydro_2 PF04909.14 ETO26036.1 - 6.3e-35 121.4 0.0 7.7e-35 121.1 0.0 1.0 1 0 0 1 1 1 1 Amidohydrolase Orthoreo_P17 PF07272.11 ETO26037.1 - 0.045 13.8 0.0 0.11 12.5 0.0 1.6 1 0 0 1 1 1 0 Orthoreovirus P17 protein TPR_2 PF07719.17 ETO26039.1 - 7.9e-13 47.5 18.4 0.00082 19.3 1.7 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26039.1 - 4.2e-11 42.2 19.0 0.00036 20.2 0.6 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26039.1 - 1.4e-09 37.7 16.2 0.0023 18.2 0.3 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26039.1 - 3e-07 30.1 16.9 0.0072 16.5 1.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26039.1 - 1.2e-06 28.7 16.6 0.0091 16.3 3.7 4.1 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26039.1 - 0.00011 22.7 0.9 16 6.6 0.0 4.3 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26039.1 - 0.0017 18.8 12.3 0.018 15.6 0.2 4.1 2 2 2 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO26039.1 - 0.0021 18.3 17.8 0.13 12.5 0.2 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_16 PF13432.6 ETO26039.1 - 0.0031 18.1 2.3 0.7 10.6 0.3 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26039.1 - 0.0068 17.0 15.8 1.3 9.8 0.5 5.0 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26039.1 - 0.014 15.4 9.0 1.5 9.0 0.3 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat TPR_15 PF13429.6 ETO26039.1 - 0.02 14.1 5.3 4.4 6.4 0.1 3.1 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26039.1 - 3.7 7.5 12.1 29 4.7 0.2 4.4 5 0 0 5 5 5 0 Tetratricopeptide repeat Helicase_C PF00271.31 ETO26040.1 - 1.6e-13 50.9 0.1 6.4e-13 49.0 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Ctf8 PF09696.10 ETO26040.1 - 0.088 13.1 6.2 13 6.1 2.9 3.4 2 1 0 2 2 2 0 Ctf8 DEAD PF00270.29 ETO26041.1 - 5.6e-06 26.2 2.6 0.00061 19.6 0.1 2.8 3 1 0 3 3 3 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO26041.1 - 0.01 16.2 2.1 0.014 15.7 0.2 2.3 2 1 0 2 2 2 0 Helicase conserved C-terminal domain Snf7 PF03357.21 ETO26043.1 - 1.7e-17 63.6 27.4 1.7e-17 63.6 27.4 1.8 1 1 1 2 2 2 1 Snf7 Flavi_DEAD PF07652.14 ETO26043.1 - 0.015 15.3 0.5 0.015 15.3 0.5 1.7 2 0 0 2 2 2 0 Flavivirus DEAD domain PEPCK_N PF17297.2 ETO26043.1 - 0.6 9.7 5.2 0.54 9.8 3.7 1.6 1 1 0 1 1 1 0 Phosphoenolpyruvate carboxykinase N-terminal domain FapA PF03961.13 ETO26043.1 - 2 6.9 20.7 0.12 10.9 9.2 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF4407 PF14362.6 ETO26043.1 - 2.3 7.5 14.3 7 5.9 14.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Prefoldin_2 PF01920.20 ETO26043.1 - 5.2 7.1 25.6 8.6 6.4 3.3 3.7 2 1 0 3 3 3 0 Prefoldin subunit GlcNAc PF11397.8 ETO26044.1 - 0.011 15.2 0.0 0.015 14.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase (GlcNAc) SDA1 PF05285.12 ETO26045.1 - 0.94 8.8 10.6 1.2 8.5 10.6 1.3 1 0 0 1 1 1 0 SDA1 Cullin_Nedd8 PF10557.9 ETO26047.1 - 1.2e-27 95.7 0.8 2e-27 95.0 0.8 1.4 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.22 ETO26047.1 - 1.5e-11 43.6 0.4 1.5e-11 43.6 0.4 1.6 2 0 0 2 2 2 1 Cullin family Penicillinase_R PF03965.16 ETO26047.1 - 0.017 15.4 0.0 0.037 14.4 0.0 1.6 1 1 0 1 1 1 0 Penicillinase repressor HTH_49 PF18010.1 ETO26047.1 - 0.021 14.7 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 Cry35Ab1 HTH C-terminal domain GatB_Yqey PF02637.18 ETO26047.1 - 0.079 12.8 1.7 0.1 12.4 1.7 1.2 1 0 0 1 1 1 0 GatB domain AAA_18 PF13238.6 ETO26049.1 - 3.5e-07 30.8 0.0 5.3e-07 30.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO26049.1 - 8.7e-05 22.7 0.0 0.00016 21.9 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ETO26049.1 - 0.00038 20.9 0.0 0.0007 20.0 0.0 1.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) NB-ARC PF00931.22 ETO26049.1 - 0.0014 17.9 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO26049.1 - 0.0079 16.5 0.0 0.016 15.5 0.0 1.5 1 1 0 1 1 1 1 AAA domain ATPase_2 PF01637.18 ETO26049.1 - 0.018 14.9 0.3 0.061 13.2 0.1 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea Torsin PF06309.11 ETO26049.1 - 0.021 14.9 0.1 0.034 14.2 0.1 1.4 1 0 0 1 1 1 0 Torsin AAA_5 PF07728.14 ETO26049.1 - 0.072 13.1 0.1 0.68 9.9 0.0 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ADK PF00406.22 ETO26049.1 - 0.088 12.9 0.0 2.4 8.2 0.0 2.4 2 1 0 2 2 2 0 Adenylate kinase AAA_16 PF13191.6 ETO26049.1 - 0.091 13.1 0.1 0.13 12.7 0.1 1.7 1 1 0 1 1 1 0 AAA ATPase domain RNA_helicase PF00910.22 ETO26049.1 - 0.12 12.7 0.1 0.34 11.3 0.0 2.0 2 1 0 2 2 2 0 RNA helicase Es2 PF09751.9 ETO26050.1 - 3.3e-51 175.4 20.8 3.3e-51 175.4 20.8 3.2 2 1 0 2 2 2 1 Nuclear protein Es2 SAM_2 PF07647.17 ETO26051.1 - 2.6e-07 30.6 0.1 4.8e-07 29.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO26051.1 - 3.5e-07 30.5 0.1 6.9e-07 29.6 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF148 PF02520.17 ETO26051.1 - 0.0089 16.1 1.1 0.0089 16.1 1.1 1.7 1 1 0 1 1 1 1 Domain of unknown function DUF148 Ndc80_HEC PF03801.13 ETO26051.1 - 0.013 15.1 0.7 0.025 14.2 0.7 1.5 1 0 0 1 1 1 0 HEC/Ndc80p family SAM_3 PF18016.1 ETO26051.1 - 0.12 12.2 0.4 0.12 12.2 0.4 2.5 3 0 0 3 3 3 0 SAM domain (Sterile alpha motif) Colicin_M PF14859.6 ETO26052.1 - 0.062 12.4 0.0 0.15 11.2 0.0 1.6 1 1 1 2 2 2 0 Colicin M PIP5K PF01504.18 ETO26053.1 - 3.8e-29 101.8 1.8 1.3e-28 100.0 0.0 2.5 2 2 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase FBA PF04300.13 ETO26054.1 - 0.051 13.3 0.2 7.1 6.3 0.0 2.1 2 0 0 2 2 2 0 F-box associated region Holin_BhlA PF10960.8 ETO26054.1 - 0.071 13.1 0.7 0.26 11.3 0.0 2.2 2 0 0 2 2 2 0 BhlA holin family DUF4208 PF13907.6 ETO26057.1 - 0.028 14.8 0.8 0.11 12.9 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4208) NEXCaM_BD PF16644.5 ETO26057.1 - 0.11 12.8 0.8 0.53 10.6 0.8 2.1 1 1 1 2 2 2 0 Regulatory region of Na+/H+ exchanger NHE binds to calmodulin WD40 PF00400.32 ETO26058.1 - 7.7e-55 181.6 22.1 4.9e-10 39.9 0.0 7.3 6 2 1 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO26058.1 - 4.3e-13 48.9 1.7 0.066 12.2 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO26058.1 - 1.4e-12 47.8 0.3 1 9.7 0.1 6.2 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain SBD PF17882.1 ETO26058.1 - 4e-05 23.4 0.5 1.1 9.1 0.0 3.6 1 1 2 3 3 3 2 OAA-family lectin sugar binding domain PD40 PF07676.12 ETO26058.1 - 0.00015 21.6 1.5 7.4 6.6 0.0 4.9 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO26058.1 - 0.00026 19.8 4.5 5.1 5.6 0.1 4.3 3 1 2 5 5 5 3 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO26058.1 - 0.0004 20.5 0.2 5.8 7.1 0.0 4.4 2 2 2 4 4 4 1 Strictosidine synthase HARP PF07443.13 ETO26058.1 - 0.0021 17.6 0.1 6.1 6.6 0.0 3.3 4 0 0 4 4 4 2 HepA-related protein (HARP) Proteasome_A_N PF10584.9 ETO26058.1 - 0.051 13.3 8.3 2.9 7.6 0.0 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature SLIDE PF09111.10 ETO26059.1 - 3.3e-08 33.5 1.8 3.3e-08 33.5 1.8 2.7 2 1 0 2 2 2 1 SLIDE Zip PF02535.22 ETO26059.1 - 0.2 10.8 13.6 0.017 14.3 5.4 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter Mem_trans PF03547.18 ETO26059.1 - 1.4 7.2 3.3 2.7 6.3 3.3 1.4 1 0 0 1 1 1 0 Membrane transport protein SID-1_RNA_chan PF13965.6 ETO26059.1 - 2.6 6.3 17.6 0.14 10.5 12.1 1.6 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 GEMIN8 PF15348.6 ETO26059.1 - 4 7.7 22.6 0.054 13.8 12.3 2.4 3 0 0 3 3 3 0 Gemini of Cajal bodies-associated protein 8 SLC12 PF03522.15 ETO26059.1 - 5 6.0 28.9 0.24 10.4 20.1 2.2 2 0 0 2 2 2 0 Solute carrier family 12 EF_assoc_1 PF08355.12 ETO26060.1 - 0.044 13.4 0.0 0.083 12.5 0.0 1.5 1 0 0 1 1 1 0 EF hand associated Ras PF00071.22 ETO26061.1 - 8.7e-13 48.2 0.3 2.7e-12 46.6 0.1 2.1 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO26061.1 - 1.9e-12 47.4 2.0 3.2e-12 46.7 0.0 2.4 3 0 0 3 3 2 1 Ras of Complex, Roc, domain of DAPkinase Septin PF00735.18 ETO26061.1 - 0.001 18.4 0.1 0.001 18.4 0.1 1.9 2 0 0 2 2 2 1 Septin EF_assoc_2 PF08356.12 ETO26061.1 - 0.0064 16.5 0.0 0.015 15.3 0.0 1.6 1 0 0 1 1 1 1 EF hand associated AAA_22 PF13401.6 ETO26061.1 - 0.011 16.0 0.1 0.92 9.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain RsgA_GTPase PF03193.16 ETO26061.1 - 0.013 15.4 2.5 3.3 7.6 0.0 3.1 3 0 0 3 3 3 0 RsgA GTPase DUF2730 PF10805.8 ETO26061.1 - 0.014 15.4 0.2 0.036 14.1 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) TniB PF05621.11 ETO26061.1 - 0.023 14.1 0.1 0.069 12.6 0.0 1.8 2 0 0 2 2 2 0 Bacterial TniB protein MMR_HSR1 PF01926.23 ETO26061.1 - 0.037 14.1 0.1 0.099 12.7 0.1 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO26061.1 - 0.094 12.2 2.9 1.8 8.1 2.9 2.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF1279 PF06916.13 ETO26061.1 - 0.1 13.1 0.4 0.34 11.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1279) AAA_14 PF13173.6 ETO26061.1 - 0.15 12.1 4.8 2.9 7.9 0.0 3.4 3 0 0 3 3 3 0 AAA domain Ribonuclease_3 PF00636.26 ETO26061.1 - 0.75 10.4 3.0 1.5 9.5 0.1 2.8 4 0 0 4 4 3 0 Ribonuclease III domain Ras PF00071.22 ETO26062.1 - 0.00022 20.9 0.6 0.0022 17.6 0.6 2.2 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO26062.1 - 0.0032 17.7 0.1 0.013 15.7 0.0 2.0 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase CENP-M PF11111.8 ETO26062.1 - 0.03 13.5 0.7 0.94 8.6 0.1 2.8 2 1 0 2 2 2 0 Centromere protein M (CENP-M) TniB PF05621.11 ETO26062.1 - 0.037 13.4 0.0 0.084 12.3 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein AAA_24 PF13479.6 ETO26062.1 - 0.038 13.7 0.1 0.1 12.3 0.1 1.7 1 0 0 1 1 1 0 AAA domain CRAL_TRIO PF00650.20 ETO26062.1 - 0.045 13.5 0.3 0.18 11.5 0.0 2.0 2 0 0 2 2 2 0 CRAL/TRIO domain MEF2_binding PF09047.10 ETO26062.1 - 0.095 12.6 2.3 0.42 10.5 2.3 2.1 1 0 0 1 1 1 0 MEF2 binding RGS PF00615.19 ETO26063.1 - 3.4e-05 24.1 1.7 3.6e-05 24.0 0.1 1.9 2 0 0 2 2 2 1 Regulator of G protein signaling domain ERGIC_N PF13850.6 ETO26063.1 - 0.083 13.2 0.4 0.083 13.2 0.4 2.9 2 1 0 2 2 2 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) GyrI-like PF06445.15 ETO26064.1 - 6e-12 46.1 0.0 1.2e-11 45.2 0.0 1.5 1 0 0 1 1 1 1 GyrI-like small molecule binding domain Cass2 PF14526.6 ETO26064.1 - 2.5e-05 24.5 0.1 0.0002 21.6 0.0 2.2 2 0 0 2 2 2 1 Integron-associated effector binding protein Glyoxalase PF00903.25 ETO26064.1 - 0.011 16.0 0.8 0.029 14.6 0.8 1.7 1 1 0 1 1 1 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily DUF2015 PF09435.10 ETO26064.1 - 0.058 13.3 0.0 0.15 12.0 0.0 1.6 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2015) TPR_2 PF07719.17 ETO26065.1 - 0.00017 21.5 0.4 0.36 11.0 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26065.1 - 0.00046 19.9 1.6 0.49 10.3 0.2 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26065.1 - 0.02 15.2 2.4 1.2 9.7 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26065.1 - 0.17 12.2 1.9 1.4 9.3 1.5 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26065.1 - 0.26 11.6 1.5 3.3 8.2 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat DDHD PF02862.17 ETO26065.1 - 0.45 10.6 7.6 0.49 10.5 7.6 1.2 1 0 0 1 1 1 0 DDHD domain Ndc1_Nup PF09531.10 ETO26065.1 - 5.4 5.6 8.3 5.4 5.6 8.3 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Neur_chan_memb PF02932.16 ETO26065.1 - 5.5 7.0 7.6 6.3 6.8 7.6 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF5521 PF17659.1 ETO26065.1 - 8.6 4.1 12.3 3.7 5.3 9.5 1.6 1 1 0 2 2 2 0 Family of unknown function (DUF5521) Rubis-subs-bind PF09273.11 ETO26066.1 - 1.7e-12 48.2 0.1 9e-12 45.8 0.0 2.2 2 0 0 2 2 2 1 Rubisco LSMT substrate-binding SET PF00856.28 ETO26066.1 - 2.1e-09 38.0 0.0 8.1e-09 36.1 0.0 2.0 2 1 0 2 2 2 1 SET domain TPR_2 PF07719.17 ETO26066.1 - 7.1e-08 32.0 1.7 0.015 15.4 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26066.1 - 1e-07 31.5 1.6 0.006 16.4 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26066.1 - 0.00063 20.4 0.2 1.2 10.2 0.1 2.7 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26066.1 - 0.0017 18.4 0.5 4 7.9 0.1 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26066.1 - 0.013 15.2 0.4 0.033 13.9 0.2 1.8 1 1 1 2 2 2 0 TPR repeat TPR_16 PF13432.6 ETO26066.1 - 0.016 15.8 1.1 0.044 14.4 1.1 1.8 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26066.1 - 0.025 15.1 0.2 0.056 14.0 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26066.1 - 0.1 12.9 0.4 0.26 11.6 0.4 1.7 1 1 0 1 1 1 0 Tetratricopeptide repeat PASTA PF03793.19 ETO26067.1 - 0.076 12.9 0.6 0.076 12.9 0.6 1.6 2 0 0 2 2 2 0 PASTA domain Tim54 PF11711.8 ETO26067.1 - 0.089 11.6 3.0 0.13 11.0 3.0 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Nop14 PF04147.12 ETO26067.1 - 3.3 5.8 12.9 0.32 9.2 8.5 1.5 2 0 0 2 2 2 0 Nop14-like family RRM_1 PF00076.22 ETO26068.1 - 6.1e-14 51.6 0.0 2.8e-13 49.5 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF2024 PF09630.10 ETO26069.1 - 0.0096 15.8 0.4 0.028 14.3 0.4 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF2024) Glyco_tran_28_C PF04101.16 ETO26069.1 - 6.8 6.6 8.0 0.28 11.1 0.8 2.3 1 1 1 2 2 2 0 Glycosyltransferase family 28 C-terminal domain tRNA_edit PF04073.15 ETO26070.1 - 8.5e-12 45.2 0.0 1.4e-11 44.5 0.0 1.3 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain zf-UBR PF02207.20 ETO26070.1 - 0.18 12.0 0.0 0.18 12.0 0.0 2.5 3 1 0 3 3 3 0 Putative zinc finger in N-recognin (UBR box) Toxin_R_bind_C PF07951.12 ETO26070.1 - 0.32 10.6 4.2 0.095 12.3 0.8 1.7 2 0 0 2 2 2 0 Clostridium neurotoxin, C-terminal receptor binding PrsW-protease PF13367.6 ETO26071.1 - 1.7e-08 34.1 11.9 4.7e-08 32.7 12.2 1.8 1 1 0 1 1 1 1 PrsW family intramembrane metalloprotease Spem1 PF15670.5 ETO26071.1 - 0.29 10.7 0.6 0.65 9.5 0.5 1.6 1 1 0 1 1 1 0 Spermatid maturation protein 1 Ac76 PF05814.11 ETO26071.1 - 4.3 7.4 5.4 6.7 6.8 1.6 2.5 2 1 0 2 2 2 0 Orf76 (Ac76) GST_C_3 PF14497.6 ETO26072.1 - 1.1e-16 60.8 0.2 1.7e-16 60.2 0.2 1.3 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO26072.1 - 5.5e-06 26.5 0.1 8.4e-06 25.9 0.1 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETO26072.1 - 0.0011 19.3 0.1 0.051 13.9 0.0 2.9 2 1 0 2 2 2 1 Glutathione S-transferase, N-terminal domain RhoGEF PF00621.20 ETO26072.1 - 0.0037 17.5 0.7 0.0053 17.0 0.7 1.2 1 0 0 1 1 1 1 RhoGEF domain GST_C_2 PF13410.6 ETO26072.1 - 0.016 15.2 0.0 0.04 14.0 0.0 1.8 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain GST_C_6 PF17171.4 ETO26072.1 - 0.12 12.2 0.1 2.1 8.2 0.1 2.8 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain Vps26 PF03643.15 ETO26073.1 - 2.3e-99 331.8 0.5 2.9e-99 331.5 0.5 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 ETO26073.1 - 0.0013 19.2 0.8 0.23 11.9 0.2 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETO26073.1 - 0.02 15.0 0.5 2.4 8.2 0.0 3.0 2 1 1 3 3 3 0 Arrestin (or S-antigen), N-terminal domain BetaGal_dom3 PF13363.6 ETO26073.1 - 0.18 11.4 0.0 0.54 9.9 0.0 1.8 2 0 0 2 2 2 0 Beta-galactosidase, domain 3 FAM176 PF14851.6 ETO26074.1 - 0.049 13.3 6.0 0.05 13.3 6.0 1.0 1 0 0 1 1 1 0 FAM176 family BSP_II PF05432.11 ETO26074.1 - 0.22 11.2 12.8 0.22 11.2 12.8 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) RNase_H2_suC PF08615.11 ETO26074.1 - 0.42 10.8 2.7 0.42 10.8 2.7 1.0 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Radial_spoke PF04712.12 ETO26074.1 - 0.75 8.7 9.7 0.75 8.7 9.7 1.0 1 0 0 1 1 1 0 Radial spokehead-like protein CLPTM1 PF05602.12 ETO26074.1 - 0.89 8.5 3.8 0.86 8.5 3.8 1.0 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) MscS_TM PF12794.7 ETO26074.1 - 1.2 7.9 5.9 1.2 7.9 5.9 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Myc_N PF01056.18 ETO26074.1 - 1.6 8.6 8.4 1.7 8.5 8.4 1.0 1 0 0 1 1 1 0 Myc amino-terminal region DUF3169 PF11368.8 ETO26074.1 - 4.8 6.6 4.7 4.6 6.7 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) PBP_sp32 PF07222.12 ETO26074.1 - 6.6 6.1 10.4 6.4 6.2 10.4 1.0 1 0 0 1 1 1 0 Proacrosin binding protein sp32 RGS PF00615.19 ETO26075.1 - 0.0004 20.7 0.2 0.00082 19.6 0.2 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain OAF PF14941.6 ETO26076.1 - 0.058 12.8 0.0 0.11 11.9 0.0 1.4 2 0 0 2 2 2 0 Transcriptional regulator, Out at first PNISR PF15996.5 ETO26077.1 - 0.89 9.8 18.5 0.56 10.5 9.1 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR MRI PF15325.6 ETO26077.1 - 2.1 9.5 14.0 2.2 9.4 3.9 2.3 2 0 0 2 2 2 0 Modulator of retrovirus infection Nop14 PF04147.12 ETO26078.1 - 9.2 4.3 41.7 14 3.8 41.7 1.2 1 0 0 1 1 1 0 Nop14-like family Cytochrom_C PF00034.21 ETO26080.1 - 1.8e-12 48.2 0.2 9.9e-09 36.2 0.3 2.1 2 0 0 2 2 2 2 Cytochrome c Cytochrome_CBB3 PF13442.6 ETO26080.1 - 3.6e-08 33.6 0.3 2.7e-05 24.4 0.3 2.2 2 0 0 2 2 2 2 Cytochrome C oxidase, cbb3-type, subunit III CCP_MauG PF03150.14 ETO26080.1 - 0.0017 19.0 0.0 0.002 18.8 0.0 1.1 1 0 0 1 1 1 1 Di-haem cytochrome c peroxidase Cytochrom_C550 PF14495.6 ETO26080.1 - 0.01 15.5 0.3 0.02 14.6 0.3 1.4 1 0 0 1 1 1 0 Cytochrome c-550 domain Ras PF00071.22 ETO26081.1 - 1.2e-32 112.8 0.1 1.6e-32 112.4 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO26081.1 - 4.8e-25 88.1 0.1 7.5e-25 87.5 0.1 1.3 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO26081.1 - 2.4e-08 33.6 0.1 2.8e-08 33.4 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF4337 PF14235.6 ETO26082.1 - 0.75 9.9 3.6 1.3 9.1 3.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) TPX2_importin PF12214.8 ETO26084.1 - 7.8e-08 32.7 1.8 7.8e-08 32.7 1.8 3.0 1 1 1 2 2 2 2 Cell cycle regulated microtubule associated protein ANAPC15 PF15243.6 ETO26084.1 - 0.04 14.3 1.1 0.04 14.3 1.1 3.0 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 15 CDC45 PF02724.14 ETO26084.1 - 2.6 6.2 14.9 2.9 6.1 14.9 1.3 1 0 0 1 1 1 0 CDC45-like protein TPR_1 PF00515.28 ETO26085.1 - 1.1e-12 47.1 9.9 0.011 15.6 0.0 6.0 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26085.1 - 1.4e-12 46.7 14.3 0.027 14.6 0.0 6.8 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26085.1 - 2.2e-12 46.2 6.3 0.041 14.1 0.1 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26085.1 - 1.4e-10 41.5 0.4 4.7e-05 23.8 0.0 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26085.1 - 4.6e-09 35.8 5.9 0.0018 17.9 0.1 5.1 4 1 1 5 5 5 3 TPR repeat TPR_12 PF13424.6 ETO26085.1 - 5.8e-09 36.1 10.7 0.0032 17.7 0.2 4.9 3 2 2 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26085.1 - 3e-08 33.5 5.5 0.33 11.4 0.2 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO26085.1 - 1.9e-07 31.6 0.4 0.019 15.6 0.1 3.6 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26085.1 - 3e-07 30.7 3.6 0.13 13.1 0.5 5.4 4 2 2 6 6 5 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO26085.1 - 4.4e-06 26.7 2.9 0.019 15.1 0.0 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO26085.1 - 9.9e-05 21.9 0.1 0.22 10.8 0.0 3.0 2 1 0 2 2 2 2 MalT-like TPR region SHNi-TPR PF10516.9 ETO26085.1 - 0.00032 20.1 0.2 0.17 11.4 0.0 3.1 4 0 0 4 4 4 1 SHNi-TPR TPR_10 PF13374.6 ETO26085.1 - 0.0013 18.6 8.2 1.9 8.4 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26085.1 - 0.0059 17.2 3.8 4 8.3 0.0 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO26085.1 - 0.026 14.9 0.0 0.96 9.8 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26085.1 - 0.043 13.9 5.6 4.7 7.5 0.0 4.1 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO26085.1 - 0.056 13.7 14.7 0.069 13.4 0.3 4.0 3 1 1 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 PX PF00787.24 ETO26086.1 - 1.8e-20 73.0 0.3 3.5e-20 72.1 0.3 1.5 1 0 0 1 1 1 1 PX domain PDZ PF00595.24 ETO26086.1 - 0.00031 21.0 0.0 0.00071 19.9 0.0 1.6 1 0 0 1 1 1 1 PDZ domain SART-1 PF03343.13 ETO26086.1 - 0.014 14.0 2.6 0.016 13.8 2.6 1.1 1 0 0 1 1 1 0 SART-1 family PDZ_6 PF17820.1 ETO26086.1 - 0.015 15.1 0.0 0.028 14.3 0.0 1.5 1 0 0 1 1 1 0 PDZ domain WD40 PF00400.32 ETO26087.1 - 1.4e-33 114.3 25.6 1.7e-06 28.6 1.6 7.4 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26087.1 - 1.3e-07 31.8 0.9 0.26 11.6 0.0 4.9 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO26087.1 - 1.4e-05 25.7 3.9 1.4e-05 25.7 3.9 2.5 2 0 0 2 2 2 1 TRAF-type zinc finger AgrB PF04647.15 ETO26087.1 - 0.00011 21.6 1.4 0.00019 20.8 1.4 1.3 1 0 0 1 1 1 1 Accessory gene regulator B Wzy_C_2 PF11846.8 ETO26087.1 - 0.026 14.5 0.3 0.044 13.7 0.3 1.3 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal FemAB PF02388.16 ETO26087.1 - 0.78 8.5 8.4 0.039 12.8 2.5 1.7 1 1 1 2 2 2 0 FemAB family Kinesin PF00225.23 ETO26088.1 - 9.6e-24 83.9 0.0 1e-23 83.8 0.0 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO26088.1 - 1e-18 67.7 0.0 1.2e-18 67.4 0.0 1.0 1 0 0 1 1 1 1 Microtubule binding DUF3141 PF11339.8 ETO26088.1 - 0.016 13.7 0.0 0.02 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3141) DUF4545 PF15078.6 ETO26088.1 - 0.017 14.1 0.1 4.2 6.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4545) T2SSE PF00437.20 ETO26088.1 - 0.059 12.4 0.0 0.071 12.2 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_22 PF13401.6 ETO26088.1 - 0.13 12.5 0.2 0.25 11.6 0.2 1.6 1 1 1 2 2 2 0 AAA domain Kelch_2 PF07646.15 ETO26090.1 - 0.004 17.1 1.5 8.4 6.6 0.2 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO26090.1 - 0.0052 16.3 1.8 0.5 10.0 0.6 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO26090.1 - 0.011 15.7 0.7 0.15 12.1 0.1 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Gal-3-0_sulfotr PF06990.11 ETO26092.1 - 0.00043 19.3 7.8 0.0049 15.8 7.8 2.1 1 1 0 1 1 1 1 Galactose-3-O-sulfotransferase PPR_2 PF13041.6 ETO26093.1 - 1.2e-16 60.6 3.5 4.3e-11 42.8 0.4 4.0 3 1 1 4 4 4 2 PPR repeat family PPR_3 PF13812.6 ETO26093.1 - 2.5e-12 46.7 2.0 4.8e-05 23.3 0.1 3.6 3 1 1 4 4 4 3 Pentatricopeptide repeat domain PPR PF01535.20 ETO26093.1 - 2.3e-09 36.9 6.7 4.5e-05 23.4 0.1 4.9 6 0 0 6 6 6 2 PPR repeat PPR_1 PF12854.7 ETO26093.1 - 2.4e-06 27.1 0.4 0.003 17.2 0.0 4.3 5 0 0 5 5 5 1 PPR repeat PPR_long PF17177.4 ETO26093.1 - 0.00024 20.5 0.2 0.03 13.7 0.0 2.3 1 1 1 2 2 2 2 Pentacotripeptide-repeat region of PRORP Vps39_1 PF10366.9 ETO26093.1 - 0.0016 18.7 2.7 1.8 8.9 0.0 3.3 1 1 2 3 3 3 2 Vacuolar sorting protein 39 domain 1 TPR_19 PF14559.6 ETO26093.1 - 0.0097 16.4 0.0 6 7.5 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO26093.1 - 0.045 14.0 0.5 0.17 12.1 0.4 2.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 DENN PF02141.21 ETO26095.1 - 3.8e-15 56.3 0.0 8e-15 55.3 0.0 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain SPA PF08616.10 ETO26095.1 - 0.0005 20.0 0.3 0.0012 18.8 0.3 1.6 1 0 0 1 1 1 1 Stabilization of polarity axis dDENN PF03455.19 ETO26095.1 - 0.0011 18.9 0.8 0.0049 16.8 0.7 2.1 1 1 0 1 1 1 1 dDENN domain Rav1p_C PF12234.8 ETO26095.1 - 0.0037 15.8 0.2 0.006 15.0 0.2 1.2 1 0 0 1 1 1 1 RAVE protein 1 C terminal Sporozoite_P67 PF05642.11 ETO26095.1 - 0.18 9.9 16.3 0.34 8.9 16.3 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SSP160 PF06933.11 ETO26095.1 - 7.7 4.6 20.0 11 4.0 20.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Kelch_4 PF13418.6 ETO26097.1 - 0.00035 20.5 0.0 0.006 16.6 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO26097.1 - 0.00038 20.4 0.2 4 7.5 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO26097.1 - 0.016 15.4 0.0 2.1 8.7 0.0 3.0 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO26097.1 - 0.026 14.1 0.0 0.33 10.6 0.0 2.6 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO26097.1 - 0.079 13.0 1.1 2 8.5 0.1 3.4 4 0 0 4 4 4 0 Kelch motif Transketolase_C PF02780.20 ETO26098.1 - 3e-05 23.9 0.0 5.1e-05 23.2 0.0 1.5 1 1 0 1 1 1 1 Transketolase, C-terminal domain Nsp1_C PF05064.13 ETO26099.1 - 7.1e-18 64.5 18.2 8.3e-17 61.1 7.9 2.8 3 0 0 3 3 3 2 Nsp1-like C-terminal region Baculo_PEP_C PF04513.12 ETO26099.1 - 0.046 13.7 10.1 0.081 13.0 3.4 2.7 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus RGS PF00615.19 ETO26100.1 - 0.0067 16.7 0.2 0.011 15.9 0.2 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Toast_rack_N PF17115.5 ETO26100.1 - 0.17 12.2 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 N-terminal domain of toast_rack, DUF2154 Methyltransf_16 PF10294.9 ETO26101.1 - 3.5e-10 39.9 0.0 6.5e-10 39.0 0.0 1.4 1 0 0 1 1 1 1 Lysine methyltransferase PrmA PF06325.13 ETO26101.1 - 0.00044 19.8 0.7 0.0014 18.1 0.7 1.8 1 1 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Bac_rhamnosid_C PF17390.2 ETO26101.1 - 0.12 12.1 0.2 0.23 11.3 0.2 1.4 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase C-terminal domain TMEM154 PF15102.6 ETO26102.1 - 0.00014 21.8 0.2 0.0002 21.3 0.2 1.2 1 0 0 1 1 1 1 TMEM154 protein family Herpes_gE PF02480.16 ETO26102.1 - 0.036 12.8 0.0 0.044 12.5 0.0 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E WBP-1 PF11669.8 ETO26102.1 - 0.14 12.8 0.8 0.21 12.2 0.4 1.5 1 1 0 1 1 1 0 WW domain-binding protein 1 Orf78 PF06024.12 ETO26103.1 - 8.4 6.8 7.7 1.5 9.1 1.7 2.5 2 1 1 3 3 3 0 Orf78 (ac78) Thioredoxin PF00085.20 ETO26105.1 - 1.1e-50 169.8 4.6 1.3e-25 89.3 0.0 5.8 5 1 0 5 5 5 3 Thioredoxin WD40 PF00400.32 ETO26105.1 - 1.7e-32 110.9 19.2 3.9e-07 30.7 1.1 7.7 7 0 0 7 7 7 5 WD domain, G-beta repeat Thioredoxin_6 PF13848.6 ETO26105.1 - 1.8e-15 57.3 6.9 5.9e-06 26.3 0.8 5.5 2 2 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ETO26105.1 - 1.9e-11 44.4 0.8 0.011 16.1 0.0 4.1 2 1 1 3 3 3 3 Thioredoxin-like domain OST3_OST6 PF04756.13 ETO26105.1 - 3.7e-09 36.4 2.7 0.015 14.7 0.0 3.7 3 1 0 4 4 4 3 OST3 / OST6 family, transporter family Thioredoxin_3 PF13192.6 ETO26105.1 - 0.002 18.1 0.3 1.6 8.9 0.0 3.6 3 0 0 3 3 3 1 Thioredoxin domain Thioredoxin_7 PF13899.6 ETO26105.1 - 0.005 17.0 0.0 0.56 10.4 0.0 2.8 2 0 0 2 2 2 1 Thioredoxin-like WD40_like PF17005.5 ETO26105.1 - 0.0065 15.8 0.0 0.23 10.8 0.0 2.8 2 0 0 2 2 2 1 WD40-like domain Thioredoxin_8 PF13905.6 ETO26105.1 - 0.024 14.9 8.1 7.6 6.9 0.0 5.7 5 1 1 6 6 5 0 Thioredoxin-like QSOX_Trx1 PF18108.1 ETO26105.1 - 0.027 14.6 0.0 0.12 12.5 0.0 2.2 1 0 0 1 1 1 0 QSOX Trx-like domain AhpC-TSA PF00578.21 ETO26105.1 - 0.091 12.7 0.2 1.7 8.5 0.0 2.8 2 0 0 2 2 2 0 AhpC/TSA family Thioredoxin_4 PF13462.6 ETO26105.1 - 0.28 11.3 13.0 0.15 12.2 0.3 4.3 4 1 0 4 4 3 0 Thioredoxin DUF3915 PF13054.6 ETO26106.1 - 0.082 12.9 3.1 0.2 11.6 3.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Pkinase PF00069.25 ETO26108.1 - 8.1e-07 28.7 0.2 2.1e-06 27.3 0.2 1.7 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26108.1 - 9.9e-07 28.3 1.8 0.00036 19.9 1.8 3.3 1 1 0 1 1 1 1 Protein tyrosine kinase C2 PF00168.30 ETO26109.1 - 2.8e-12 46.8 1.3 8e-12 45.4 1.3 1.8 1 0 0 1 1 1 1 C2 domain Golgin_A5 PF09787.9 ETO26109.1 - 0.00014 21.4 89.9 0.00036 20.1 25.8 4.9 3 1 2 5 5 5 2 Golgin subfamily A member 5 APG6_N PF17675.1 ETO26109.1 - 0.00052 20.5 104.7 0.054 14.0 24.0 5.9 1 1 4 5 5 5 3 Apg6 coiled-coil region FlaC_arch PF05377.11 ETO26109.1 - 0.0018 18.6 2.3 0.0018 18.6 2.3 9.0 4 4 4 8 8 8 1 Flagella accessory protein C (FlaC) GAS PF13851.6 ETO26109.1 - 0.0027 17.1 93.8 0.012 15.0 27.9 5.7 3 1 3 6 6 6 3 Growth-arrest specific micro-tubule binding DUF2968 PF11180.8 ETO26109.1 - 0.0045 16.6 25.3 0.0045 16.6 25.3 5.3 4 1 2 6 6 6 1 Protein of unknown function (DUF2968) ZapB PF06005.12 ETO26109.1 - 0.008 16.6 5.9 0.008 16.6 5.9 8.5 5 2 2 7 7 6 3 Cell division protein ZapB CENP-F_leu_zip PF10473.9 ETO26109.1 - 0.016 15.2 90.5 0.032 14.2 4.9 6.0 3 1 3 6 6 5 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4472 PF14739.6 ETO26109.1 - 0.016 15.9 6.9 0.016 15.9 6.9 6.3 3 1 3 6 6 6 0 Domain of unknown function (DUF4472) DHR10 PF18595.1 ETO26109.1 - 0.019 15.0 17.6 0.019 15.0 17.6 6.7 3 2 4 7 7 7 0 Designed helical repeat protein 10 domain DUF4497 PF14924.6 ETO26109.1 - 0.045 14.2 0.1 0.045 14.2 0.1 2.6 3 0 0 3 3 2 0 Protein of unknown function (DUF4497) ATG16 PF08614.11 ETO26109.1 - 0.13 12.5 95.1 0.23 11.7 30.2 5.2 2 2 3 5 5 5 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 ETO26109.1 - 0.14 12.2 96.0 0.3 11.2 5.6 6.2 3 1 1 5 5 5 0 TPR/MLP1/MLP2-like protein Spc7 PF08317.11 ETO26109.1 - 0.22 10.4 98.7 0.028 13.3 18.4 4.8 2 2 3 5 5 5 0 Spc7 kinetochore protein YabA PF06156.13 ETO26109.1 - 2.2 9.0 77.2 0.24 12.1 4.0 7.5 3 1 3 6 6 5 0 Initiation control protein YabA DUF812 PF05667.11 ETO26109.1 - 3.5 6.4 82.8 0.78 8.5 11.2 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF812) DUF1664 PF07889.12 ETO26109.1 - 9.6 6.3 54.4 0.25 11.4 10.5 5.1 3 1 1 5 5 5 0 Protein of unknown function (DUF1664) Alpha-mann_mid PF09261.11 ETO26110.1 - 2.2e-23 82.2 0.0 3.5e-23 81.6 0.0 1.4 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38C PF07748.13 ETO26110.1 - 3.2e-11 43.7 0.0 4.4e-11 43.3 0.0 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain ubiquitin PF00240.23 ETO26112.1 - 2.5e-05 23.9 4.2 0.38 10.5 0.4 3.3 2 1 1 3 3 3 3 Ubiquitin family WD40 PF00400.32 ETO26113.1 - 1.2e-08 35.4 2.3 0.0073 17.1 0.2 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat YMF19 PF02326.15 ETO26114.1 - 0.19 12.5 0.3 0.19 12.5 0.3 4.5 2 2 2 5 5 5 0 Plant ATP synthase F0 Ferric_reduct PF01794.19 ETO26116.1 - 6.1e-10 39.3 12.1 1.6e-09 37.9 12.1 1.8 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ETO26116.1 - 3.2e-07 30.4 0.0 8.7e-07 29.0 0.0 1.8 1 0 0 1 1 1 1 FAD-binding domain DUF4405 PF14358.6 ETO26116.1 - 0.012 16.2 1.0 0.012 16.2 1.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4405) DUF1435 PF07256.12 ETO26116.1 - 0.15 12.2 5.8 0.33 11.1 0.7 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1435) DUF2828 PF11443.8 ETO26118.1 - 0.011 13.8 4.7 0.011 13.8 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) DUF4604 PF15377.6 ETO26118.1 - 0.055 13.9 23.9 0.073 13.5 23.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) Spc42p PF11544.8 ETO26120.1 - 0.0088 16.0 0.3 0.019 15.0 0.3 1.6 1 0 0 1 1 1 1 Spindle pole body component Spc42p FapA PF03961.13 ETO26120.1 - 0.0099 14.5 1.5 0.011 14.4 1.5 1.0 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF3543 PF12063.8 ETO26120.1 - 0.021 14.2 0.8 0.027 13.9 0.8 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) CortBP2 PF09727.9 ETO26120.1 - 0.036 14.0 7.0 0.047 13.6 7.0 1.1 1 0 0 1 1 1 0 Cortactin-binding protein-2 CorA PF01544.18 ETO26120.1 - 0.057 12.7 0.1 0.064 12.6 0.1 1.1 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein PCRF PF03462.18 ETO26120.1 - 0.062 13.2 1.2 0.073 12.9 1.2 1.1 1 0 0 1 1 1 0 PCRF domain DUF4200 PF13863.6 ETO26120.1 - 1 9.8 9.3 6.8 7.1 2.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) AAA_23 PF13476.6 ETO26120.1 - 1.2 9.6 7.1 1.8 9.0 7.1 1.3 1 1 0 1 1 1 0 AAA domain Rx_N PF18052.1 ETO26120.1 - 2 8.8 6.5 1.6 9.1 0.9 2.2 2 0 0 2 2 2 0 Rx N-terminal domain Mcl1_mid PF12341.8 ETO26122.1 - 1.7e-37 129.4 1.1 5.9e-37 127.6 0.1 2.1 2 0 0 2 2 2 1 Minichromosome loss protein, Mcl1, middle region ANAPC4_WD40 PF12894.7 ETO26122.1 - 0.001 19.3 0.0 3 8.2 0.0 3.8 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO26122.1 - 0.43 11.5 3.3 20 6.3 0.0 4.9 5 0 0 5 5 5 0 WD domain, G-beta repeat RabGAP-TBC PF00566.18 ETO26123.1 - 2.6e-29 102.4 0.2 2.6e-29 102.4 0.2 1.7 2 0 0 2 2 2 1 Rab-GTPase-TBC domain UCH PF00443.29 ETO26124.1 - 1.9e-71 240.6 0.0 2.9e-71 240.0 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ETO26124.1 - 2.6e-19 69.6 0.6 2.6e-19 69.6 0.6 2.5 2 0 0 2 2 2 1 DUSP domain UCH_1 PF13423.6 ETO26124.1 - 5.6e-10 39.3 0.1 0.015 14.9 0.0 3.4 3 0 0 3 3 3 3 Ubiquitin carboxyl-terminal hydrolase USP7_C2 PF14533.6 ETO26124.1 - 0.0034 17.1 0.1 0.008 15.9 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin-specific protease C-terminal Tudor-knot PF11717.8 ETO26124.1 - 0.67 9.9 5.4 0.58 10.1 2.0 2.6 2 1 0 2 2 2 0 RNA binding activity-knot of a chromodomain CENP-Q PF13094.6 ETO26125.1 - 0.042 14.0 0.5 0.098 12.9 0.5 1.5 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit Choline_transpo PF04515.12 ETO26125.1 - 0.93 8.6 7.9 0.26 10.5 0.9 2.1 1 1 0 2 2 2 0 Plasma-membrane choline transporter YMF19 PF02326.15 ETO26125.1 - 2.1 9.2 7.0 0.45 11.3 1.8 2.2 1 1 1 2 2 2 0 Plant ATP synthase F0 zf-H2C2_2 PF13465.6 ETO26126.1 - 7.8e-14 51.4 18.1 6.1e-10 39.1 1.3 3.7 3 0 0 3 3 3 3 Zinc-finger double domain zf-C2H2 PF00096.26 ETO26126.1 - 2.7e-12 46.4 20.1 7.7e-05 22.9 1.3 3.8 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_6 PF13912.6 ETO26126.1 - 7.6e-06 25.8 18.5 0.0042 17.0 1.2 3.8 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ETO26126.1 - 0.0019 18.9 8.7 0.014 16.1 0.7 4.1 4 0 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETO26126.1 - 0.007 16.6 1.1 0.007 16.6 1.1 3.8 3 0 0 3 3 3 1 Zinc-finger double-stranded RNA-binding zf-BED PF02892.15 ETO26126.1 - 0.047 13.7 15.8 0.54 10.3 0.7 3.7 1 1 2 3 3 3 0 BED zinc finger FYVE_2 PF02318.16 ETO26126.1 - 0.14 12.4 3.4 0.34 11.1 3.4 1.6 1 0 0 1 1 1 0 FYVE-type zinc finger zf-CHCC PF10276.9 ETO26126.1 - 0.16 12.1 0.3 0.16 12.1 0.3 2.3 2 0 0 2 2 2 0 Zinc-finger domain zf-C2H2_11 PF16622.5 ETO26126.1 - 0.22 11.3 9.1 4.3 7.2 0.1 3.4 3 0 0 3 3 3 0 zinc-finger C2H2-type DZR PF12773.7 ETO26126.1 - 0.49 10.5 7.3 5 7.2 7.5 2.2 1 1 1 2 2 2 0 Double zinc ribbon zf-met PF12874.7 ETO26126.1 - 0.63 10.5 15.7 0.62 10.5 1.2 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Zn-ribbon_8 PF09723.10 ETO26126.1 - 0.65 10.2 12.9 2.8 8.1 0.5 3.2 1 1 1 3 3 3 0 Zinc ribbon domain XPA_N PF01286.18 ETO26126.1 - 1.2 9.3 10.3 5.2 7.2 0.1 3.8 4 0 0 4 4 4 0 XPA protein N-terminal zf-trcl PF13451.6 ETO26126.1 - 2.7 7.9 6.7 12 5.8 1.5 2.5 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-LYAR PF08790.11 ETO26126.1 - 4 7.4 10.3 4.8 7.2 0.1 3.6 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zinc-ribbons_6 PF07191.12 ETO26126.1 - 7.3 6.6 7.5 15 5.6 2.3 2.5 1 1 1 2 2 2 0 zinc-ribbons DUF2256 PF10013.9 ETO26126.1 - 7.7 6.7 6.6 17 5.7 0.3 3.1 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) Transp_Tc5_C PF04236.15 ETO26127.1 - 0.038 14.3 1.2 0.038 14.3 1.2 2.0 2 0 0 2 2 2 0 Tc5 transposase C-terminal domain TFB6 PF17110.5 ETO26128.1 - 0.0029 17.4 3.3 0.0033 17.2 3.3 1.2 1 0 0 1 1 1 1 Subunit 11 of the general transcription factor TFIIH TT_ORF2 PF02957.15 ETO26128.1 - 0.0045 17.9 0.7 0.006 17.5 0.7 1.3 1 0 0 1 1 1 1 TT viral ORF2 Cytomega_UL84 PF06284.11 ETO26128.1 - 0.47 8.9 6.7 0.49 8.8 6.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Pox_Ag35 PF03286.14 ETO26128.1 - 1.4 8.7 8.4 1.7 8.4 8.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Thg1C PF14413.6 ETO26129.1 - 0.023 14.9 0.2 0.031 14.4 0.2 1.2 1 0 0 1 1 1 0 Thg1 C terminal domain IBR PF01485.21 ETO26130.1 - 9.7e-07 28.9 20.1 7.6e-05 22.9 3.1 3.2 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain Macoilin PF09726.9 ETO26132.1 - 0.023 13.3 26.9 0.027 13.0 26.9 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 ETO26132.1 - 0.061 12.5 21.1 0.081 12.1 21.1 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF572 PF04502.13 ETO26132.1 - 0.12 12.0 22.9 0.17 11.5 22.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF572) Utp14 PF04615.13 ETO26132.1 - 0.28 9.7 29.1 0.35 9.4 29.1 1.1 1 0 0 1 1 1 0 Utp14 protein LAP1C PF05609.12 ETO26132.1 - 0.32 10.0 20.3 0.47 9.5 20.3 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Ndc1_Nup PF09531.10 ETO26132.1 - 2.9 6.5 14.0 4.4 5.9 14.0 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 ETO26132.1 - 3.1 6.7 17.7 5.1 6.0 17.7 1.4 1 0 0 1 1 1 0 Solute carrier family 12 AMPK1_CBM PF16561.5 ETO26133.1 - 0.063 13.5 0.0 0.1 12.8 0.0 1.3 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase DUF913 PF06025.12 ETO26134.1 - 0.02 13.9 3.5 0.022 13.7 3.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Zip PF02535.22 ETO26134.1 - 0.024 13.9 3.2 0.032 13.5 3.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO26134.1 - 0.047 13.7 1.9 0.051 13.6 1.9 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region MCM_bind PF09739.9 ETO26134.1 - 0.063 11.7 5.8 0.076 11.4 5.8 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DTHCT PF08070.11 ETO26134.1 - 0.19 12.5 8.1 0.29 11.9 8.1 1.2 1 0 0 1 1 1 0 DTHCT (NUC029) region NPR3 PF03666.13 ETO26134.1 - 0.43 9.3 7.1 0.45 9.3 7.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO26134.1 - 1.3 7.8 5.4 1.4 7.6 5.4 1.1 1 0 0 1 1 1 0 Presenilin Cnd1_N PF12922.7 ETO26135.1 - 4.3e-08 33.2 0.3 2e-07 31.0 0.0 2.2 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1, N-term Neurochondrin PF05536.11 ETO26135.1 - 0.0046 15.4 0.0 0.0046 15.4 0.0 1.1 1 0 0 1 1 1 1 Neurochondrin Ac76 PF05814.11 ETO26135.1 - 0.013 15.4 0.2 0.055 13.5 0.2 2.0 1 0 0 1 1 1 0 Orf76 (Ac76) LRR_6 PF13516.6 ETO26136.1 - 0.11 12.6 1.1 0.21 11.8 0.1 2.1 2 0 0 2 2 2 0 Leucine Rich repeat DUF573 PF04504.14 ETO26137.1 - 0.0048 17.5 2.7 0.0065 17.1 2.7 1.3 1 0 0 1 1 1 1 Protein of unknown function, DUF573 Jak1_Phl PF17887.1 ETO26137.1 - 1.5 8.8 8.5 1.9 8.4 8.2 1.3 1 1 0 1 1 1 0 Jak1 pleckstrin homology-like domain Presenilin PF01080.17 ETO26137.1 - 5.1 5.8 4.4 5.3 5.7 4.4 1.1 1 0 0 1 1 1 0 Presenilin Pkinase PF00069.25 ETO26138.1 - 6.8e-48 163.3 0.0 1e-47 162.7 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26138.1 - 3.4e-27 95.3 0.0 4.9e-27 94.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO26138.1 - 1.5e-05 24.0 0.0 2.9e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO26138.1 - 2.6e-05 23.7 0.0 4.2e-05 23.0 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO26138.1 - 7.5e-05 22.2 0.1 0.00013 21.4 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETO26138.1 - 0.12 12.0 0.5 0.32 10.6 0.0 1.9 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.25 ETO26139.1 - 4e-12 46.1 0.6 6.7e-12 45.3 0.6 1.4 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 ETO26139.1 - 3e-08 34.1 0.6 3e-08 34.1 0.6 2.0 1 1 1 2 2 2 1 PH domain Pkinase_Tyr PF07714.17 ETO26139.1 - 5.5e-07 29.1 0.1 1.1e-06 28.1 0.1 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase PH_13 PF16652.5 ETO26139.1 - 0.0055 16.5 0.0 0.017 14.9 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO26139.1 - 0.019 15.4 5.2 0.97 9.9 0.1 3.2 3 1 1 4 4 4 0 Pleckstrin homology domain ubiquitin PF00240.23 ETO26140.1 - 1.7e-21 75.7 0.0 2.6e-21 75.2 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO26140.1 - 1.6e-08 34.2 0.1 2.5e-08 33.6 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO26140.1 - 5.2e-05 23.7 0.0 8e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO26140.1 - 0.0011 19.1 0.0 0.002 18.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like SNARE PF05739.19 ETO26141.1 - 5.6e-09 35.9 1.3 5.6e-09 35.9 1.3 2.3 2 1 0 2 2 2 1 SNARE domain Syntaxin PF00804.25 ETO26141.1 - 0.00038 20.2 0.1 0.00038 20.2 0.1 1.8 3 0 0 3 3 3 1 Syntaxin CHASE3 PF05227.13 ETO26141.1 - 0.088 12.7 0.6 2.8 7.9 0.1 2.0 1 1 0 2 2 2 0 CHASE3 domain WD40 PF00400.32 ETO26142.1 - 2.8e-53 176.7 19.1 3.8e-10 40.2 0.1 7.5 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26142.1 - 1.5e-20 73.3 3.8 0.00069 19.9 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26142.1 - 4.2e-16 58.8 2.0 0.027 13.4 0.0 6.8 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO26142.1 - 1.1e-09 37.9 7.9 0.15 12.0 0.0 6.8 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO26142.1 - 3.6e-08 33.1 6.9 0.0003 20.2 1.1 2.8 1 1 0 2 2 2 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO26142.1 - 5.9e-08 32.2 4.9 9.2e-07 28.3 0.8 2.0 1 1 1 2 2 2 2 Coatomer WD associated region SGL PF08450.12 ETO26142.1 - 1.5e-06 28.0 0.4 0.054 13.1 0.0 3.6 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region DPPIV_N PF00930.21 ETO26142.1 - 2.6e-06 26.5 1.2 0.0065 15.3 0.1 4.1 1 1 2 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cytochrom_D1 PF02239.16 ETO26142.1 - 0.00014 20.5 2.6 0.017 13.7 0.2 3.4 1 1 3 4 4 4 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO26142.1 - 0.0014 17.4 7.2 0.09 11.4 0.7 4.2 1 1 1 4 4 4 1 Nucleoporin Nup120/160 Ubiquitin_3 PF14836.6 ETO26142.1 - 0.0048 16.9 0.2 5.6 7.0 0.0 3.4 3 1 1 4 4 4 1 Ubiquitin-like domain Nbas_N PF15492.6 ETO26142.1 - 0.0066 15.8 1.6 2.2 7.5 0.0 3.6 3 1 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DUF3475 PF11961.8 ETO26142.1 - 0.032 14.3 0.1 1.6 8.8 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3475) ImmE5 PF11480.8 ETO26142.1 - 0.08 13.4 0.7 2.7 8.6 0.1 3.2 2 1 1 3 3 3 0 Colicin-E5 Imm protein Proteasome_A_N PF10584.9 ETO26142.1 - 0.15 11.8 9.1 15 5.4 0.0 5.2 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO26143.1 - 0.00078 19.7 6.5 0.051 13.9 0.0 4.5 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO26143.1 - 0.00084 18.9 1.1 1.4 8.5 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO26143.1 - 0.044 13.8 13.1 6.9 6.8 0.1 5.4 6 0 0 6 6 6 0 Kelch motif Choline_transpo PF04515.12 ETO26144.1 - 1.3e-77 261.3 35.5 4e-77 259.6 29.7 2.1 1 1 1 2 2 2 2 Plasma-membrane choline transporter TMEM223 PF14640.6 ETO26144.1 - 0.082 13.1 1.6 19 5.4 0.0 3.0 3 0 0 3 3 3 0 Transmembrane protein 223 Pkinase PF00069.25 ETO26146.1 - 6e-11 42.2 0.0 2.1e-10 40.4 0.0 2.0 2 0 0 2 2 2 1 Protein kinase domain Arabino_trans_C PF14896.6 ETO26146.1 - 0.89 8.5 6.8 0.037 13.0 1.1 1.5 2 0 0 2 2 2 0 EmbC C-terminal domain Hid1 PF12722.7 ETO26146.1 - 2.6 6.1 13.0 0.11 10.6 5.9 1.8 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein NPR3 PF03666.13 ETO26146.1 - 4.7 5.9 13.6 4.2 6.0 1.0 2.1 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Pkinase PF00069.25 ETO26147.1 - 1.5e-07 31.0 0.2 7.3e-07 28.8 0.2 1.9 1 1 0 1 1 1 1 Protein kinase domain PI3_PI4_kinase PF00454.27 ETO26148.1 - 3.4e-30 105.7 0.3 1.1e-19 71.3 0.1 2.1 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase DUF4135 PF13575.6 ETO26148.1 - 0.0099 15.2 0.0 0.013 14.8 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4135) Virul_Fac PF10139.9 ETO26149.1 - 0.055 11.7 0.7 0.088 11.0 0.7 1.2 1 0 0 1 1 1 0 Putative bacterial virulence factor DUF3439 PF11921.8 ETO26149.1 - 6.7 6.7 6.2 14 5.6 6.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) VBS PF08913.10 ETO26150.1 - 0.0068 16.8 0.6 0.02 15.3 0.5 1.8 2 0 0 2 2 2 1 Vinculin Binding Site MCLC PF05934.11 ETO26150.1 - 0.022 13.5 0.9 0.033 12.9 0.9 1.2 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) GvpK PF05121.12 ETO26150.1 - 0.43 10.6 4.9 2.2 8.4 0.2 3.1 3 0 0 3 3 3 0 Gas vesicle protein K Cep57_MT_bd PF06657.13 ETO26150.1 - 0.82 10.2 13.4 1 9.8 2.2 3.2 2 1 1 3 3 3 0 Centrosome microtubule-binding domain of Cep57 Synapsin PF02078.16 ETO26152.1 - 1.4e-16 60.6 0.0 2.3e-16 59.9 0.0 1.3 1 0 0 1 1 1 1 Synapsin, N-terminal domain Synapsin_C PF02750.14 ETO26152.1 - 3.5e-05 23.4 0.0 6.5e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 Synapsin, ATP binding domain WD40 PF00400.32 ETO26153.1 - 1.1e-49 165.4 18.9 9.4e-10 38.9 0.3 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26153.1 - 2.1e-22 79.2 0.5 3.5e-05 24.0 0.0 6.9 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26153.1 - 1.6e-11 43.8 0.1 0.0045 16.0 0.0 5.2 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO26153.1 - 3e-05 24.1 1.7 2.5 8.2 0.1 3.6 3 1 1 4 4 4 3 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO26153.1 - 5.6e-05 22.6 4.2 0.013 14.8 0.1 2.8 3 0 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO26153.1 - 0.00018 20.3 3.2 1.8 7.1 0.1 4.3 2 1 3 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO26153.1 - 0.012 14.2 0.2 0.77 8.2 0.0 2.2 2 0 0 2 2 2 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO26153.1 - 0.013 14.4 1.2 12 4.7 0.0 3.5 2 2 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO26153.1 - 0.014 15.3 5.0 8.1 6.5 0.0 5.1 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO26153.1 - 0.046 13.7 0.0 14 5.9 0.0 4.0 5 0 0 5 5 5 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETO26153.1 - 0.048 13.4 3.1 16 5.3 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature CDC4_D PF16856.5 ETO26153.1 - 0.23 11.4 2.3 0.66 9.9 2.3 1.7 1 0 0 1 1 1 0 Cell division control protein 4 dimerisation domain DnaG_DnaB_bind PF08278.11 ETO26154.1 - 0.034 14.8 0.1 0.7 10.5 0.1 2.3 2 0 0 2 2 2 0 DNA primase DnaG DnaB-binding TcA_RBD PF18518.1 ETO26154.1 - 0.083 13.2 0.4 0.18 12.1 0.1 1.7 2 0 0 2 2 2 0 TcA receptor binding domain CPSase_L_D2 PF02786.17 ETO26154.1 - 0.09 12.3 0.1 0.12 11.8 0.1 1.2 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Kelch_5 PF13854.6 ETO26155.1 - 4.2e-05 23.4 5.6 1.4 9.0 0.0 4.1 4 1 0 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO26155.1 - 8.7e-05 22.5 9.1 0.4 10.7 0.1 5.4 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO26155.1 - 0.0022 18.2 1.8 14 6.1 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO26155.1 - 0.0031 17.8 6.5 0.37 11.1 0.0 4.7 5 0 0 5 5 5 1 Galactose oxidase, central domain RhoGAP PF00620.27 ETO26156.1 - 5.2e-34 117.3 0.2 9.5e-34 116.4 0.2 1.4 1 0 0 1 1 1 1 RhoGAP domain YMF19 PF02326.15 ETO26156.1 - 0.06 14.1 2.3 0.06 14.1 2.3 2.2 3 0 0 3 3 3 0 Plant ATP synthase F0 zf-C2H2 PF00096.26 ETO26157.1 - 1.8e-07 31.2 30.9 0.0013 19.1 2.9 4.5 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO26157.1 - 4.3e-05 24.0 28.9 0.028 15.3 3.2 4.7 4 1 0 4 4 4 3 C2H2-type zinc finger zf-Di19 PF05605.12 ETO26157.1 - 0.00053 20.2 11.2 0.00053 20.2 11.2 3.4 2 1 0 3 3 3 1 Drought induced 19 protein (Di19), zinc-binding DUF2256 PF10013.9 ETO26157.1 - 0.0039 17.3 0.6 1.8 8.8 0.1 2.8 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2256) zf-LYAR PF08790.11 ETO26157.1 - 0.022 14.7 1.7 0.13 12.1 0.3 2.9 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger zf-C2H2_2 PF12756.7 ETO26157.1 - 0.024 15.0 3.2 0.024 15.0 3.2 4.1 1 1 3 4 4 4 0 C2H2 type zinc-finger (2 copies) zf-H2C2_5 PF13909.6 ETO26157.1 - 0.079 12.7 0.8 0.079 12.7 0.8 4.2 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-trcl PF13451.6 ETO26157.1 - 0.61 10.0 6.9 0.3 11.0 3.7 2.3 2 0 0 2 2 2 0 Probable zinc-ribbon domain zf-C2H2_11 PF16622.5 ETO26157.1 - 1.1 9.1 7.7 0.73 9.6 0.4 2.8 2 0 0 2 2 2 0 zinc-finger C2H2-type zf-C2H2_9 PF16293.5 ETO26157.1 - 8.7 6.3 8.8 4.5 7.2 0.6 3.2 2 1 1 3 3 3 0 C2H2 type zinc-finger (1 copy) WD40 PF00400.32 ETO26159.1 - 0.13 13.2 0.1 0.32 11.9 0.1 1.6 1 0 0 1 1 1 0 WD domain, G-beta repeat PI3K_1B_p101 PF10486.9 ETO26160.1 - 0.012 13.4 0.3 0.015 13.1 0.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF1657 PF07870.11 ETO26160.1 - 2.8 7.9 6.5 5.2 7.0 0.1 3.2 3 1 0 3 3 3 0 Protein of unknown function (DUF1657) DUF2353 PF09789.9 ETO26162.1 - 0.0021 17.5 10.5 0.0064 15.9 10.5 1.7 1 1 0 1 1 1 1 Uncharacterized coiled-coil protein (DUF2353) TPR_MLP1_2 PF07926.12 ETO26162.1 - 0.01 15.9 15.3 0.017 15.2 15.3 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TSNAXIP1_N PF15739.5 ETO26162.1 - 0.073 13.4 7.4 0.12 12.8 7.4 1.4 1 0 0 1 1 1 0 Translin-associated factor X-interacting N-terminus DUF1041 PF06292.17 ETO26162.1 - 0.082 13.3 4.8 0.21 12.0 4.8 1.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF1041) M PF02370.16 ETO26162.1 - 0.23 12.1 17.6 0.81 10.5 9.8 3.2 2 0 0 2 2 2 0 M protein repeat Noelin-1 PF12308.8 ETO26162.1 - 0.35 10.9 3.0 0.55 10.2 1.6 1.9 1 1 0 1 1 1 0 Neurogenesis glycoprotein Exonuc_VII_L PF02601.15 ETO26162.1 - 0.45 10.0 12.6 0.48 9.9 12.6 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit UPF0242 PF06785.11 ETO26162.1 - 0.59 10.2 16.7 0.099 12.7 5.4 2.1 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Phage_Mu_Gam PF07352.12 ETO26162.1 - 0.64 9.9 9.6 1.1 9.2 9.6 1.5 1 1 0 1 1 1 0 Bacteriophage Mu Gam like protein DASH_Dam1 PF08653.10 ETO26162.1 - 0.68 9.8 6.1 2.1 8.2 0.9 3.0 2 1 1 3 3 3 0 DASH complex subunit Dam1 DUF4407 PF14362.6 ETO26162.1 - 0.77 9.1 6.7 0.88 8.9 6.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5082 PF16888.5 ETO26162.1 - 0.89 9.8 8.8 0.81 10.0 2.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) OmpH PF03938.14 ETO26162.1 - 1 9.7 12.1 1.2 9.4 12.1 1.3 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) TMF_TATA_bd PF12325.8 ETO26162.1 - 1.3 9.3 11.4 0.15 12.3 3.3 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding Ribosomal_L27e PF01777.18 ETO26162.1 - 3.4 8.1 6.5 20 5.6 2.5 2.9 1 1 0 2 2 2 0 Ribosomal L27e protein family Fib_alpha PF08702.10 ETO26162.1 - 4.3 7.5 8.1 7.7 6.7 8.1 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family Ax_dynein_light PF10211.9 ETO26162.1 - 5.7 6.8 12.8 2.9 7.8 7.8 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain UPF0449 PF15136.6 ETO26162.1 - 5.7 7.5 11.9 0.53 10.8 1.4 2.9 2 1 1 3 3 3 0 Uncharacterised protein family UPF0449 IZUMO PF15005.6 ETO26162.1 - 8.1 7.0 8.2 7.1 7.1 6.4 1.7 1 1 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated Laminin_G_3 PF13385.6 ETO26163.1 - 1.5e-20 73.9 0.0 4.2e-20 72.4 0.0 1.8 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF3439 PF11921.8 ETO26163.1 - 0.63 10.0 10.6 14 5.7 9.7 3.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) HECT PF00632.25 ETO26164.1 - 2e-70 237.7 0.1 3.8e-70 236.8 0.1 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ETO26164.1 - 4e-12 46.3 0.3 1e-11 45.0 0.3 1.8 1 0 0 1 1 1 1 SPRY domain PA PF02225.22 ETO26164.1 - 0.0012 18.8 0.0 0.0031 17.5 0.0 1.6 1 0 0 1 1 1 1 PA domain FAD-oxidase_C PF02913.19 ETO26165.1 - 1.1e-28 100.5 0.1 1.9e-28 99.8 0.1 1.4 1 0 0 1 1 1 1 FAD linked oxidases, C-terminal domain FAD_binding_4 PF01565.23 ETO26165.1 - 3.5e-26 91.6 0.0 6.3e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 FAD binding domain Toprim_Crpt PF13342.6 ETO26165.1 - 0.012 15.6 1.6 0.032 14.2 1.6 1.7 1 0 0 1 1 1 0 C-terminal repeat of topoisomerase Fer2 PF00111.27 ETO26166.1 - 4.4e-10 39.4 4.0 5.5e-10 39.1 4.0 1.1 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain TFIIA PF03153.13 ETO26167.1 - 0.00027 21.1 14.0 0.00038 20.6 14.0 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit Pkinase PF00069.25 ETO26167.1 - 0.001 18.5 0.0 0.0019 17.6 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pox_Ag35 PF03286.14 ETO26167.1 - 0.26 11.1 22.3 0.54 10.0 15.5 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein AC_N PF16214.5 ETO26167.1 - 3.6 6.6 6.3 5 6.2 6.3 1.1 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region Thiamine_BP PF01910.17 ETO26168.1 - 0.091 12.7 0.0 0.18 11.8 0.0 1.5 1 0 0 1 1 1 0 Thiamine-binding protein OB_NTP_bind PF07717.16 ETO26169.1 - 3.8e-16 59.2 0.0 6.8e-16 58.4 0.0 1.4 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold DRAT PF07357.11 ETO26169.1 - 0.027 13.6 0.3 0.046 12.9 0.3 1.3 1 0 0 1 1 1 0 Dinitrogenase reductase ADP-ribosyltransferase (DRAT) ATP-synt_E PF05680.12 ETO26169.1 - 0.88 10.0 6.5 1.6 9.1 6.5 1.5 1 0 0 1 1 1 0 ATP synthase E chain Helicase_C PF00271.31 ETO26170.1 - 3.6e-15 56.3 0.0 9.2e-15 55.0 0.0 1.7 1 0 0 1 1 1 1 Helicase conserved C-terminal domain HA2 PF04408.23 ETO26170.1 - 8.9e-14 51.7 0.0 8.9e-14 51.7 0.0 2.4 2 1 0 2 2 1 1 Helicase associated domain (HA2) DEAD PF00270.29 ETO26170.1 - 3e-06 27.1 0.0 5.8e-06 26.2 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO26170.1 - 3.1e-05 24.3 0.1 0.0001 22.6 0.1 1.8 1 1 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO26170.1 - 0.00081 19.2 0.0 0.002 17.9 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_7 PF12775.7 ETO26170.1 - 0.0035 16.9 0.0 0.0065 16.0 0.0 1.4 1 0 0 1 1 1 1 P-loop containing dynein motor region T2SSE PF00437.20 ETO26170.1 - 0.0052 15.9 0.0 0.012 14.7 0.0 1.6 1 0 0 1 1 1 1 Type II/IV secretion system protein Sigma54_activat PF00158.26 ETO26170.1 - 0.0058 16.3 0.0 0.029 14.1 0.0 2.2 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA_5 PF07728.14 ETO26170.1 - 0.007 16.4 0.1 4.9 7.1 0.0 2.7 3 0 0 3 3 2 1 AAA domain (dynein-related subfamily) Microtub_bd PF16796.5 ETO26170.1 - 0.01 15.8 3.0 0.017 15.1 0.8 2.4 3 0 0 3 3 3 1 Microtubule binding AAA_33 PF13671.6 ETO26170.1 - 0.012 15.8 0.0 0.034 14.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ETO26170.1 - 0.013 15.5 0.1 0.18 11.8 0.1 2.5 1 1 0 1 1 1 0 AAA domain SRP54 PF00448.22 ETO26170.1 - 0.014 15.0 0.0 0.045 13.4 0.0 1.9 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain ResIII PF04851.15 ETO26170.1 - 0.014 15.4 2.3 5.7 6.9 0.0 3.4 3 0 0 3 3 3 0 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETO26170.1 - 0.02 15.2 0.0 0.044 14.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO26170.1 - 0.026 14.0 0.0 0.081 12.4 0.0 1.8 1 0 0 1 1 1 0 PhoH-like protein Sigma54_activ_2 PF14532.6 ETO26170.1 - 0.031 14.4 0.0 0.11 12.7 0.0 1.8 2 0 0 2 2 1 0 Sigma-54 interaction domain Flavi_DEAD PF07652.14 ETO26170.1 - 0.038 14.0 0.0 0.093 12.7 0.0 1.7 1 1 0 1 1 1 0 Flavivirus DEAD domain ABC_tran PF00005.27 ETO26170.1 - 0.043 14.3 0.0 0.043 14.3 0.0 2.7 2 1 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ETO26170.1 - 0.056 13.8 0.0 0.16 12.4 0.0 1.8 1 0 0 1 1 1 0 AAA ATPase domain RsgA_GTPase PF03193.16 ETO26170.1 - 0.056 13.3 0.0 0.15 11.9 0.0 1.7 1 0 0 1 1 1 0 RsgA GTPase Glug PF07581.12 ETO26170.1 - 0.18 12.3 0.1 0.46 11.0 0.1 1.7 1 0 0 1 1 1 0 The GLUG motif cobW PF02492.19 ETO26170.1 - 0.18 11.4 0.9 0.81 9.3 0.2 2.3 1 1 1 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain CAF1 PF04857.20 ETO26172.1 - 2.2e-09 36.9 0.0 4e-09 36.1 0.0 1.4 1 0 0 1 1 1 1 CAF1 family ribonuclease TFIIF_alpha PF05793.12 ETO26173.1 - 0.088 11.4 23.4 0.086 11.4 13.8 2.3 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) FAM176 PF14851.6 ETO26173.1 - 5 6.8 8.7 5.5 6.6 2.3 2.7 3 0 0 3 3 3 0 FAM176 family ArfGap PF01412.18 ETO26174.1 - 1.7e-14 53.9 0.5 4.4e-11 42.9 0.1 2.4 2 1 0 2 2 2 2 Putative GTPase activating protein for Arf zf-B_box PF00643.24 ETO26174.1 - 0.059 13.5 3.3 0.14 12.3 0.5 2.2 2 0 0 2 2 2 0 B-box zinc finger CG-1 PF03859.16 ETO26174.1 - 0.06 13.1 0.9 0.15 11.8 0.0 1.9 2 0 0 2 2 2 0 CG-1 domain DUF4260 PF14079.6 ETO26174.1 - 0.15 12.1 0.1 0.22 11.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4260) TF_Zn_Ribbon PF08271.12 ETO26174.1 - 0.18 11.3 3.0 16 5.1 1.0 3.2 3 0 0 3 3 3 0 TFIIB zinc-binding G-alpha PF00503.20 ETO26175.1 - 1.3e-15 57.4 0.2 1.9e-15 56.9 0.2 1.2 1 0 0 1 1 1 1 G-protein alpha subunit TniB PF05621.11 ETO26175.1 - 3.3e-05 23.4 0.3 4.1e-05 23.1 0.3 1.1 1 0 0 1 1 1 1 Bacterial TniB protein Arf PF00025.21 ETO26175.1 - 0.0096 15.4 0.0 0.015 14.8 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_22 PF13401.6 ETO26175.1 - 0.014 15.7 0.1 0.022 15.0 0.0 1.4 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 ETO26175.1 - 0.014 14.8 0.2 0.11 11.9 0.0 2.1 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit AAA_16 PF13191.6 ETO26175.1 - 0.022 15.2 0.0 0.028 14.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain PduV-EutP PF10662.9 ETO26175.1 - 0.056 13.2 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 ETO26175.1 - 0.059 13.4 0.1 0.12 12.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain Roc PF08477.13 ETO26175.1 - 0.1 12.9 0.0 0.17 12.1 0.0 1.4 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase LMBR1 PF04791.16 ETO26175.1 - 0.26 10.2 1.8 0.29 10.0 1.8 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein AAA_33 PF13671.6 ETO26175.1 - 0.36 11.0 2.6 0.75 9.9 0.1 2.4 2 1 0 2 2 2 0 AAA domain Nop14 PF04147.12 ETO26176.1 - 0.55 8.4 26.1 0.75 7.9 26.1 1.3 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 ETO26176.1 - 1.8 7.0 22.5 2.1 6.8 22.5 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 ETO26176.1 - 3.2 4.8 16.2 3.7 4.5 16.2 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 ETO26176.1 - 9.2 4.7 25.7 13 4.2 25.7 1.2 1 0 0 1 1 1 0 Utp14 protein LAP1C PF05609.12 ETO26176.1 - 9.6 5.2 17.9 12 4.9 17.9 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) QLQ PF08880.11 ETO26177.1 - 0.00056 19.6 0.1 0.0017 18.1 0.1 1.8 1 0 0 1 1 1 1 QLQ GP88 PF17338.2 ETO26178.1 - 0.038 13.4 0.1 0.046 13.2 0.1 1.1 1 0 0 1 1 1 0 Gene product 88 OST-HTH PF12872.7 ETO26180.1 - 0.019 14.8 0.0 0.029 14.2 0.0 1.4 1 0 0 1 1 1 0 OST-HTH/LOTUS domain Shisa PF13908.6 ETO26181.1 - 7.8e-05 23.0 5.5 7.8e-05 23.0 5.5 3.2 2 1 2 4 4 4 1 Wnt and FGF inhibitory regulator DUF1179 PF06678.11 ETO26181.1 - 0.026 14.5 5.9 0.97 9.4 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) PRA1 PF03208.19 ETO26181.1 - 0.36 10.4 1.8 0.6 9.7 1.8 1.2 1 0 0 1 1 1 0 PRA1 family protein CBP_BcsG PF11658.8 ETO26181.1 - 3 6.1 8.4 0.14 10.5 2.7 1.6 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsG Ribosomal_L4 PF00573.22 ETO26183.1 - 2.7e-24 85.9 0.1 2.7e-24 85.9 0.1 1.7 2 0 0 2 2 2 1 Ribosomal protein L4/L1 family Ribos_L4_asso_C PF14374.6 ETO26183.1 - 1.2e-16 60.6 1.1 1.2e-16 60.6 1.1 2.1 2 0 0 2 2 2 1 60S ribosomal protein L4 C-terminal domain p450 PF00067.22 ETO26184.1 - 8.2e-39 133.6 0.5 1.5e-37 129.4 0.1 2.5 2 1 0 2 2 2 1 Cytochrome P450 RNase_PH PF01138.21 ETO26185.1 - 1e-07 32.5 0.0 1.9e-07 31.7 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 SLS PF14611.6 ETO26185.1 - 0.033 14.0 0.0 0.048 13.5 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator RNase_PH_C PF03725.15 ETO26185.1 - 0.072 13.1 0.1 0.14 12.2 0.1 1.6 1 0 0 1 1 1 0 3' exoribonuclease family, domain 2 Cohesin PF00963.18 ETO26185.1 - 0.095 13.0 0.1 0.23 11.7 0.1 1.6 1 0 0 1 1 1 0 Cohesin domain KH_1 PF00013.29 ETO26185.1 - 0.098 12.5 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 KH domain DFRP_C PF16543.5 ETO26186.1 - 7.4 7.1 12.8 63 4.2 13.9 1.9 1 1 1 2 2 2 0 DRG Family Regulatory Proteins, Tma46 FYVE PF01363.21 ETO26187.1 - 2.1e-10 40.6 9.2 5.9e-10 39.1 9.2 1.8 1 0 0 1 1 1 1 FYVE zinc finger Clathrin PF00637.20 ETO26187.1 - 0.039 13.8 0.2 0.092 12.6 0.2 1.6 1 0 0 1 1 1 0 Region in Clathrin and VPS FYVE_2 PF02318.16 ETO26187.1 - 4.6 7.5 10.9 1.2 9.4 6.4 2.3 2 0 0 2 2 2 0 FYVE-type zinc finger ILEI PF15711.5 ETO26189.1 - 2.1e-07 31.3 0.0 4e-07 30.4 0.0 1.4 1 0 0 1 1 1 1 Interleukin-like EMT inducer C2 PF00168.30 ETO26191.1 - 2.3e-18 66.4 0.3 5.5e-18 65.2 0.3 1.7 1 0 0 1 1 1 1 C2 domain Glyco_hydro_97 PF10566.9 ETO26193.1 - 0.08 12.2 0.1 0.096 11.9 0.1 1.1 1 0 0 1 1 1 0 Glycoside hydrolase 97 COG5 PF10392.9 ETO26194.1 - 2.9 8.1 11.1 0.15 12.3 2.2 2.5 2 1 0 2 2 2 0 Golgi transport complex subunit 5 TPR_1 PF00515.28 ETO26195.1 - 0.013 15.3 2.0 0.023 14.5 0.5 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26195.1 - 0.016 15.4 0.2 0.044 14.0 0.2 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26195.1 - 0.037 14.3 0.1 0.097 13.0 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26195.1 - 0.082 12.6 0.2 0.2 11.4 0.2 1.7 1 0 0 1 1 1 0 TPR repeat TPR_2 PF07719.17 ETO26195.1 - 0.1 12.7 2.2 0.18 12.0 0.5 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat HELP PF03451.14 ETO26196.1 - 9.8e-05 22.1 0.1 0.00014 21.6 0.1 1.3 1 0 0 1 1 1 1 HELP motif PT PF04886.12 ETO26198.1 - 0.0026 17.3 2.1 0.0039 16.7 2.1 1.2 1 0 0 1 1 1 1 PT repeat 2-Hacid_dh_C PF02826.19 ETO26198.1 - 0.0036 16.7 0.0 0.0055 16.1 0.0 1.2 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain GDPD PF03009.17 ETO26199.1 - 0.045 13.5 1.5 0.076 12.7 1.5 1.4 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family Sas6_CC PF18594.1 ETO26199.1 - 0.86 9.4 4.6 2.6 7.9 0.1 3.0 2 1 1 3 3 3 0 Sas6/XLF/XRCC4 coiled-coil domain DUF5617 PF18493.1 ETO26199.1 - 3.3 7.9 6.7 2.8 8.1 0.1 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5617) CbiK PF06180.11 ETO26200.1 - 0.02 14.3 0.1 2.1 7.6 0.0 2.2 2 0 0 2 2 2 0 Cobalt chelatase (CbiK) TRP PF06011.12 ETO26200.1 - 0.037 12.7 1.2 0.052 12.3 1.2 1.3 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel CsgA PF17334.2 ETO26200.1 - 0.044 14.5 0.1 0.14 12.9 0.1 1.8 1 0 0 1 1 1 0 Minor curli fiber component A DUF2555 PF10742.9 ETO26200.1 - 0.06 13.2 0.0 0.12 12.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2555) WD40 PF00400.32 ETO26201.1 - 4.2e-14 52.7 18.2 0.0013 19.5 1.0 8.7 8 1 1 9 9 9 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26201.1 - 5.3e-07 29.8 2.4 0.0069 16.7 0.1 5.7 4 2 4 8 8 8 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ PF01011.21 ETO26201.1 - 0.00025 20.8 0.6 0.0037 17.1 0.1 3.0 3 0 0 3 3 3 1 PQQ enzyme repeat WD40_like PF17005.5 ETO26201.1 - 0.0019 17.6 3.0 0.32 10.3 2.0 3.3 2 1 0 2 2 2 1 WD40-like domain PQQ_3 PF13570.6 ETO26201.1 - 0.0068 16.9 0.0 50 4.6 0.0 4.6 5 0 0 5 5 5 0 PQQ-like domain Nucleoporin_N PF08801.11 ETO26201.1 - 0.07 11.9 2.6 0.28 9.9 0.2 2.8 2 1 2 4 4 4 0 Nup133 N terminal like DUF5122 PF17164.4 ETO26201.1 - 1.1 9.6 5.0 17 5.8 0.2 3.5 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller MIOX PF05153.15 ETO26203.1 - 1.8e-103 345.5 10.6 1.8e-103 345.5 10.6 1.5 2 0 0 2 2 2 1 Myo-inositol oxygenase HD PF01966.22 ETO26203.1 - 0.14 12.4 0.1 0.83 9.9 0.0 2.2 2 0 0 2 2 2 0 HD domain PAP_assoc PF03828.19 ETO26204.1 - 0.00041 20.5 0.1 0.0016 18.6 0.1 2.1 1 0 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETO26204.1 - 0.0035 17.6 0.0 0.0095 16.2 0.0 1.8 1 0 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO26204.1 - 0.012 15.7 0.0 0.032 14.3 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase RPA43_OB PF17875.1 ETO26204.1 - 0.027 15.1 3.0 4 8.1 0.4 2.7 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I FAT PF02259.23 ETO26205.1 - 0.016 14.4 0.2 0.049 12.9 0.0 1.7 2 0 0 2 2 2 0 FAT domain FAM176 PF14851.6 ETO26205.1 - 0.027 14.1 3.1 0.76 9.4 1.3 2.2 2 0 0 2 2 2 0 FAM176 family PGA2 PF07543.12 ETO26205.1 - 0.8 9.7 5.3 0.12 12.4 0.7 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 Zip PF02535.22 ETO26206.1 - 0.0018 17.6 16.3 0.013 14.7 16.3 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter YajC PF02699.15 ETO26209.1 - 0.066 13.1 0.1 0.15 11.9 0.1 1.6 1 0 0 1 1 1 0 Preprotein translocase subunit Abhydrolase_1 PF00561.20 ETO26210.1 - 2.7e-06 27.2 0.0 4.3e-06 26.6 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO26210.1 - 8.2e-06 26.6 0.0 1e-05 26.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Hydrolase_4 PF12146.8 ETO26210.1 - 1.2e-05 24.7 0.2 4.4e-05 22.9 0.2 2.0 1 1 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ETO26210.1 - 0.00021 21.2 0.0 0.00049 20.0 0.0 1.6 1 0 0 1 1 1 1 alpha/beta hydrolase fold Esterase PF00756.20 ETO26210.1 - 0.00062 19.5 0.5 0.0032 17.1 0.0 2.3 1 1 1 2 2 2 1 Putative esterase Abhydrolase_2 PF02230.16 ETO26210.1 - 0.024 14.5 0.4 5.6 6.7 0.0 2.6 3 0 0 3 3 2 0 Phospholipase/Carboxylesterase Presenilin PF01080.17 ETO26210.1 - 0.052 12.3 11.8 0.36 9.6 9.7 2.1 2 0 0 2 2 2 0 Presenilin Esterase_phd PF10503.9 ETO26210.1 - 0.094 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Esterase PHB depolymerase Chlorophyllase2 PF12740.7 ETO26210.1 - 0.097 11.6 0.1 0.18 10.7 0.1 1.4 1 0 0 1 1 1 0 Chlorophyllase enzyme PPL5 PF18168.1 ETO26210.1 - 0.27 10.5 9.0 2.2 7.5 0.0 2.2 2 0 0 2 2 2 0 Prim-pol family 5 CSG2 PF16965.5 ETO26210.1 - 0.44 9.4 6.0 0.067 12.1 0.5 2.2 2 1 0 2 2 2 0 Ceramide synthase regulator Neur_chan_memb PF02932.16 ETO26210.1 - 0.88 9.6 8.4 4.1 7.4 5.9 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO26210.1 - 0.94 8.6 9.0 0.19 10.9 4.1 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter SpoIIIAH PF12685.7 ETO26210.1 - 1.3 8.8 14.1 1 9.1 7.3 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein Afi1 PF07792.12 ETO26210.1 - 1.6 9.3 12.9 16 6.0 0.2 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF913 PF06025.12 ETO26210.1 - 2 7.3 9.0 5.9 5.8 4.9 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) DUF4239 PF14023.6 ETO26211.1 - 0.018 14.8 0.0 0.039 13.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) RSB_motif PF16294.5 ETO26211.1 - 2.3 8.5 12.1 0.5 10.7 2.3 2.8 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif Shisa PF13908.6 ETO26212.1 - 0.14 12.4 0.1 0.28 11.4 0.1 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator Pkinase PF00069.25 ETO26213.1 - 9.3e-10 38.3 0.0 1.3e-09 37.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain NatB_MDM20 PF09797.9 ETO26214.1 - 0.019 13.9 0.3 0.026 13.5 0.3 1.2 1 0 0 1 1 1 0 N-acetyltransferase B complex (NatB) non catalytic subunit DUF148 PF02520.17 ETO26214.1 - 0.02 15.0 2.5 0.12 12.5 2.3 2.0 1 1 1 2 2 2 0 Domain of unknown function DUF148 CCM2_C PF16545.5 ETO26214.1 - 0.089 13.3 0.1 0.21 12.1 0.1 1.7 1 1 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology YojJ PF10372.9 ETO26214.1 - 0.17 12.0 1.0 0.84 9.8 0.4 2.3 1 1 1 2 2 2 0 Bacterial membrane-spanning protein N-terminus DUF448 PF04296.13 ETO26215.1 - 0.095 12.6 0.0 0.22 11.4 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF448) SCAB-Ig PF16709.5 ETO26215.1 - 0.12 12.5 0.5 0.81 9.8 0.0 2.6 3 0 0 3 3 3 0 Ig domain of plant-specific actin-binding protein DUF948 PF06103.11 ETO26217.1 - 0.027 14.7 0.5 0.027 14.7 0.5 5.2 4 2 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Phospholamban PF04272.14 ETO26217.1 - 0.63 9.5 4.6 0.48 9.9 1.3 2.5 1 1 1 2 2 2 0 Phospholamban Pox_A_type_inc PF04508.12 ETO26217.1 - 0.77 9.7 8.1 7.8 6.5 0.1 5.4 6 0 0 6 6 6 0 Viral A-type inclusion protein repeat PocR PF10114.9 ETO26217.1 - 0.79 9.5 10.1 2.4 7.9 0.1 3.8 3 0 0 3 3 3 0 Sensory domain found in PocR Gti1_Pac2 PF09729.9 ETO26219.1 - 0.93 9.5 4.3 0.76 9.8 1.0 2.2 2 0 0 2 2 2 0 Gti1/Pac2 family Connexin PF00029.19 ETO26219.1 - 3.6 7.3 4.3 14 5.4 0.8 2.4 2 0 0 2 2 2 0 Connexin NIF PF03031.18 ETO26221.1 - 3.1e-18 66.0 0.3 2.1e-16 60.1 0.3 2.4 1 1 0 1 1 1 1 NLI interacting factor-like phosphatase PAXIP1_C PF15364.6 ETO26221.1 - 0.087 13.1 1.4 0.15 12.4 0.1 2.1 2 0 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein 4_1_CTD PF05902.13 ETO26221.1 - 0.11 12.6 6.1 0.57 10.3 5.7 2.1 2 0 0 2 2 2 0 4.1 protein C-terminal domain (CTD) DUF3439 PF11921.8 ETO26221.1 - 0.62 10.0 3.4 0.7 9.9 1.7 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Kinesin PF00225.23 ETO26222.1 - 3e-30 105.3 0.6 5.7e-30 104.4 0.6 1.4 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO26222.1 - 7.8e-14 51.9 0.6 1.4e-13 51.1 0.6 1.5 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 ETO26223.1 - 2.3e-47 161.5 1.4 2.3e-47 161.5 1.4 2.3 2 0 0 2 2 2 1 Kinesin motor domain Methyltransf_12 PF08242.12 ETO26223.1 - 0.17 12.6 1.3 0.62 10.8 1.3 1.9 1 0 0 1 1 1 0 Methyltransferase domain PI3_PI4_kinase PF00454.27 ETO26224.1 - 7.3e-26 91.5 2.9 4e-12 46.5 0.3 2.9 2 1 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase PCEMA1 PF07418.11 ETO26224.1 - 9.2 5.7 11.2 1.7 8.1 5.0 2.1 2 0 0 2 2 2 0 Acidic phosphoprotein precursor PCEMA1 Presenilin PF01080.17 ETO26225.1 - 7.2 5.3 7.7 13 4.5 7.7 1.4 1 0 0 1 1 1 0 Presenilin RNF220 PF15926.5 ETO26226.1 - 0.0062 16.2 0.7 0.0084 15.8 0.7 1.2 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase RNF220 Nup88 PF10168.9 ETO26226.1 - 0.0082 14.0 2.7 0.0088 13.9 2.7 1.1 1 0 0 1 1 1 1 Nuclear pore component Nnf1 PF03980.14 ETO26226.1 - 0.13 12.7 2.6 0.13 12.7 0.9 1.9 2 1 0 2 2 2 0 Nnf1 Proteasome PF00227.26 ETO26227.1 - 2.2e-17 63.2 2.1 7.8e-17 61.4 2.1 1.7 1 1 0 1 1 1 1 Proteasome subunit PUA PF01472.20 ETO26227.1 - 0.046 13.7 0.3 0.12 12.3 0.3 1.7 1 0 0 1 1 1 0 PUA domain Death_2 PF14786.6 ETO26229.1 - 0.18 11.7 1.4 0.56 10.1 0.1 2.3 2 0 0 2 2 2 0 Tube Death domain PH_10 PF15411.6 ETO26229.1 - 0.28 11.4 8.4 0.62 10.3 0.2 4.0 4 0 0 4 4 4 0 Pleckstrin homology domain SSP160 PF06933.11 ETO26229.1 - 4.3 5.4 16.1 9 4.4 16.1 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 TPR_12 PF13424.6 ETO26230.1 - 2.1e-23 82.4 2.7 1.7e-13 50.6 1.0 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26230.1 - 6.5e-15 54.0 13.6 2.3e-06 27.4 0.9 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26230.1 - 3.7e-13 48.9 0.4 0.00028 20.7 0.1 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26230.1 - 1.6e-12 46.5 0.7 9.5e-05 22.2 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26230.1 - 2.4e-10 39.7 13.0 0.00016 21.5 0.6 3.6 3 1 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26230.1 - 5.3e-10 38.7 18.3 2.6e-06 27.0 1.0 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26230.1 - 4.7e-05 23.7 0.2 4.2 8.2 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO26230.1 - 0.00036 20.5 3.0 0.032 14.3 0.1 2.9 1 1 2 3 3 3 1 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETO26230.1 - 0.0023 17.4 2.2 0.08 12.3 0.6 2.2 1 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 ETO26230.1 - 0.0026 18.4 0.0 0.86 10.3 0.0 2.5 3 0 0 3 3 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO26230.1 - 0.0033 17.2 6.9 0.031 14.1 0.6 2.1 1 1 1 2 2 2 2 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETO26230.1 - 0.0044 17.3 3.9 0.49 10.9 0.1 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO26230.1 - 0.022 14.5 5.1 0.23 11.1 2.2 2.0 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETO26230.1 - 0.028 14.1 9.4 1.7 8.4 0.4 4.2 3 2 2 5 5 5 0 TPR repeat DUF3856 PF12968.7 ETO26230.1 - 0.049 13.7 0.2 0.13 12.4 0.2 1.8 1 1 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_14 PF13428.6 ETO26230.1 - 0.073 13.9 0.0 41 5.4 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF627 PF04781.12 ETO26230.1 - 0.099 12.7 0.2 2.8 8.0 0.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF627) DASH_Dad4 PF08650.10 ETO26230.1 - 0.77 9.8 4.4 0.24 11.4 0.3 2.2 2 1 0 2 2 2 0 DASH complex subunit Dad4 TPR_3 PF07720.12 ETO26230.1 - 2.9 8.0 8.5 0.66 10.0 0.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat Fer4_12 PF13353.6 ETO26231.1 - 0.088 13.1 0.3 3 8.1 0.0 2.6 2 1 1 3 3 3 0 4Fe-4S single cluster domain Menin PF05053.13 ETO26232.1 - 0.49 8.7 6.0 0.57 8.5 6.0 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO26232.1 - 1 8.0 2.7 1.2 7.9 2.7 1.1 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETO26232.1 - 7.9 7.5 8.1 4.3 8.4 5.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Zip PF02535.22 ETO26232.1 - 8.6 5.5 5.5 14 4.8 5.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter CAP_GLY PF01302.25 ETO26235.1 - 2.2e-10 40.4 1.1 4.9e-10 39.3 0.1 1.9 2 0 0 2 2 2 1 CAP-Gly domain WGR PF05406.15 ETO26237.1 - 1.1e-05 25.4 0.1 1.1e-05 25.4 0.1 1.6 2 0 0 2 2 2 1 WGR domain AAA_lid_3 PF17862.1 ETO26237.1 - 0.088 12.6 0.1 0.17 11.7 0.1 1.5 1 0 0 1 1 1 0 AAA+ lid domain PIEZO PF15917.5 ETO26237.1 - 9.8 5.6 7.6 11 5.4 7.6 1.2 1 0 0 1 1 1 0 Piezo EXS PF03124.14 ETO26238.1 - 2.8e-06 26.9 0.3 4.1e-06 26.4 0.3 1.2 1 0 0 1 1 1 1 EXS family EXS PF03124.14 ETO26239.1 - 1.6e-23 83.6 14.4 2.6e-23 82.9 14.4 1.3 1 0 0 1 1 1 1 EXS family SPX PF03105.19 ETO26239.1 - 1.7e-09 38.1 0.5 2.1e-09 37.8 0.5 1.1 1 0 0 1 1 1 1 SPX domain Mucin PF01456.17 ETO26239.1 - 1.3 9.0 9.5 2.1 8.3 9.5 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein Chorein_N PF12624.7 ETO26241.1 - 0.00034 20.7 0.1 0.00034 20.7 0.1 2.3 3 0 0 3 3 3 1 N-terminal region of Chorein or VPS13 PH PF00169.29 ETO26242.1 - 2e-14 53.9 2.3 2e-14 53.9 2.3 2.0 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ETO26242.1 - 3.4e-06 27.1 4.3 6.3e-06 26.2 0.3 2.7 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 ETO26242.1 - 0.00052 20.2 0.6 0.0011 19.2 0.6 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO26242.1 - 0.0016 18.8 6.5 0.0016 18.8 6.5 3.5 3 2 0 3 3 3 1 Pleckstrin homology domain HSP90 PF00183.18 ETO26243.1 - 5.5e-11 42.1 0.0 8.3e-11 41.5 0.0 1.3 1 1 0 1 1 1 1 Hsp90 protein WWE PF02825.20 ETO26245.1 - 6.1e-10 39.5 0.4 9.7e-10 38.9 0.4 1.3 1 0 0 1 1 1 1 WWE domain DZR PF12773.7 ETO26245.1 - 2.4e-05 24.2 1.0 3.7e-05 23.6 1.0 1.3 1 0 0 1 1 1 1 Double zinc ribbon zf-ribbon_3 PF13248.6 ETO26245.1 - 0.00024 20.4 2.7 0.00039 19.7 2.7 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zinc_ribbon_15 PF17032.5 ETO26245.1 - 0.017 15.8 0.2 0.025 15.3 0.2 1.5 1 0 0 1 1 1 0 zinc-ribbon family Succ_DH_flav_C PF02910.20 ETO26246.1 - 0.02 14.9 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Fumarate reductase flavoprotein C-term Mog1 PF04603.12 ETO26247.1 - 3.3e-32 111.7 0.0 7e-32 110.7 0.0 1.6 1 1 0 1 1 1 1 Ran-interacting Mog1 protein Mucin PF01456.17 ETO26248.1 - 0.06 13.3 7.2 0.11 12.5 7.2 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Di19_C PF14571.6 ETO26248.1 - 0.11 13.1 0.1 0.11 13.1 0.1 2.6 3 0 0 3 3 3 0 Stress-induced protein Di19, C-terminal AP-5_subunit_s1 PF15001.6 ETO26249.1 - 0.0062 16.5 7.9 0.01 15.8 7.9 1.4 1 0 0 1 1 1 1 AP-5 complex subunit sigma-1 Erf4 PF10256.9 ETO26249.1 - 0.16 12.1 1.4 0.24 11.5 0.1 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family Sporozoite_P67 PF05642.11 ETO26249.1 - 0.56 8.2 14.3 0.83 7.7 14.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen GREB1 PF15782.5 ETO26249.1 - 0.96 6.5 12.0 1.1 6.2 12.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer RR_TM4-6 PF06459.12 ETO26249.1 - 2.5 7.8 24.0 0.51 10.1 18.5 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Nudix_hydro PF18290.1 ETO26249.1 - 4.9 7.2 8.5 0.23 11.5 0.3 2.6 2 1 1 3 3 3 0 Nudix hydrolase domain Mitofilin PF09731.9 ETO26249.1 - 7.9 5.2 28.7 12 4.6 28.7 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein zf-CCCH PF00642.24 ETO26250.1 - 8e-07 28.8 5.8 8e-07 28.8 5.8 3.4 3 1 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO26250.1 - 1.4e-05 24.8 9.8 0.004 16.9 3.6 2.5 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ETO26250.1 - 4.1e-05 23.9 7.7 0.054 14.0 2.2 2.6 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 ETO26250.1 - 0.0024 17.9 19.2 0.0081 16.2 6.8 3.0 3 0 0 3 3 3 2 Zinc finger domain Macoilin PF09726.9 ETO26250.1 - 0.085 11.4 14.9 0.1 11.1 14.9 1.2 1 0 0 1 1 1 0 Macoilin family KRTAP PF11759.8 ETO26251.1 - 8.2 7.1 9.4 1.6 9.3 5.5 1.7 2 0 0 2 2 2 0 Keratin-associated matrix THP2 PF09432.10 ETO26252.1 - 0.033 14.2 0.7 0.065 13.3 0.7 1.5 1 0 0 1 1 1 0 Tho complex subunit THP2 TPR_12 PF13424.6 ETO26255.1 - 1.1e-34 118.5 12.9 2.9e-13 49.9 1.0 3.4 2 1 2 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26255.1 - 6.3e-22 76.8 1.6 4.1e-07 29.7 0.7 4.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26255.1 - 5.1e-17 60.6 3.6 0.00017 21.4 0.0 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26255.1 - 1.2e-16 59.7 13.8 1.2e-05 24.9 0.2 4.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26255.1 - 3.7e-14 51.7 7.2 0.0052 16.9 0.0 4.8 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26255.1 - 2e-12 46.2 8.2 0.00097 19.1 0.7 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26255.1 - 3.1e-08 33.1 2.3 0.0093 15.6 0.0 3.9 3 0 0 3 3 3 2 TPR repeat TPR_6 PF13174.6 ETO26255.1 - 4.9e-07 30.0 3.5 0.066 13.9 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26255.1 - 1.9e-06 28.2 0.1 0.67 10.9 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat NRBF2_MIT PF17169.4 ETO26255.1 - 0.00036 20.7 4.2 0.72 10.1 0.0 4.5 3 1 1 4 4 4 1 MIT domain of nuclear receptor-binding factor 2 TPR_MalT PF17874.1 ETO26255.1 - 0.0004 19.9 0.2 0.044 13.2 0.1 2.3 1 1 1 2 2 2 2 MalT-like TPR region DUF5113 PF17140.4 ETO26255.1 - 0.0024 17.7 0.1 0.4 10.5 0.0 3.2 3 0 0 3 3 3 1 Domain of unknown function (DUF5113) TPR_17 PF13431.6 ETO26255.1 - 0.0032 17.7 2.6 1.5 9.4 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO26255.1 - 0.012 15.5 1.6 3.6 7.7 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat SNAP PF14938.6 ETO26255.1 - 0.018 14.5 3.6 0.88 8.9 0.3 2.3 1 1 1 2 2 2 0 Soluble NSF attachment protein, SNAP TPR_4 PF07721.14 ETO26255.1 - 0.038 14.6 0.1 0.14 12.9 0.1 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO26255.1 - 0.059 14.0 0.7 0.64 10.7 0.5 2.6 2 1 0 2 2 2 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO26255.1 - 0.071 12.6 1.8 0.56 9.7 0.0 3.2 4 1 0 4 4 4 0 SHNi-TPR ANAPC3 PF12895.7 ETO26255.1 - 0.16 12.2 1.4 0.4 10.9 0.5 2.3 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Kelch_1 PF01344.25 ETO26256.1 - 9.1e-07 28.4 1.8 0.037 13.6 0.2 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO26256.1 - 0.0032 17.7 3.4 0.15 12.4 0.2 3.2 3 1 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO26256.1 - 0.016 15.2 2.8 1.7 8.7 0.1 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO26256.1 - 0.034 14.5 1.3 0.34 11.3 0.0 3.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO26256.1 - 0.046 13.7 1.6 7.1 6.8 0.1 3.3 3 0 0 3 3 3 0 Kelch motif PCC_BT PF18140.1 ETO26256.1 - 0.22 11.9 0.2 0.49 10.7 0.2 1.5 1 0 0 1 1 1 0 Propionyl-coenzyme A carboxylase BT domain Rhodanese PF00581.20 ETO26257.1 - 7.2e-12 45.8 0.0 1e-07 32.4 0.0 2.3 2 0 0 2 2 2 2 Rhodanese-like domain BPD_transp_2 PF02653.16 ETO26257.1 - 0.062 12.5 0.0 0.4 9.8 0.0 1.9 2 0 0 2 2 2 0 Branched-chain amino acid transport system / permease component SpoVAD PF07451.11 ETO26258.1 - 0.23 10.1 0.4 0.35 9.5 0.4 1.2 1 0 0 1 1 1 0 Stage V sporulation protein AD (SpoVAD) GTP1_OBG PF01018.22 ETO26259.1 - 0.26 10.9 4.5 0.051 13.2 1.2 1.6 2 0 0 2 2 2 0 GTP1/OBG BTB PF00651.31 ETO26260.1 - 0.0018 18.5 0.1 0.0067 16.6 0.1 2.0 1 0 0 1 1 1 1 BTB/POZ domain GOLD_2 PF13897.6 ETO26260.1 - 0.12 12.9 3.2 11 6.6 0.0 2.4 2 0 0 2 2 2 0 Golgi-dynamics membrane-trafficking H_PPase PF03030.16 ETO26261.1 - 0.2 10.2 1.2 0.24 10.0 1.2 1.1 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase DUF727 PF05303.12 ETO26262.1 - 0.00039 20.5 0.7 0.0014 18.6 0.7 1.8 1 1 0 1 1 1 1 Protein of unknown function (DUF727) Presenilin PF01080.17 ETO26264.1 - 0.42 9.3 2.2 0.51 9.0 2.2 1.1 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO26264.1 - 2.4 6.6 9.0 2.7 6.5 9.0 1.1 1 0 0 1 1 1 0 Macoilin family DUF3211 PF11485.8 ETO26265.1 - 0.08 13.2 0.0 0.31 11.2 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3211) CENP-B_dimeris PF09026.10 ETO26265.1 - 3.3 8.2 8.1 35 4.9 7.4 2.9 3 0 0 3 3 3 0 Centromere protein B dimerisation domain PrsW-protease PF13367.6 ETO26266.1 - 2.5e-09 36.9 8.5 1.2e-08 34.6 8.5 2.2 1 1 0 1 1 1 1 PrsW family intramembrane metalloprotease YhfC PF10086.9 ETO26266.1 - 0.024 14.0 0.9 0.23 10.8 0.9 2.4 2 0 0 2 2 2 0 YhfC intramembrane metalloprotease UDPG_MGDP_dh_N PF03721.14 ETO26267.1 - 0.0058 16.2 0.5 0.0093 15.6 0.2 1.5 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain DUF2877 PF11392.8 ETO26267.1 - 0.23 12.2 0.1 0.41 11.4 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2877) MIT PF04212.18 ETO26269.1 - 0.025 14.6 0.3 2 8.6 0.0 2.4 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain Ashwin PF15323.6 ETO26269.1 - 4.5 7.2 8.9 0.93 9.5 0.3 2.4 3 0 0 3 3 3 0 Developmental protein MAP17 PF15807.5 ETO26270.1 - 0.28 11.4 1.3 14 5.9 0.0 2.8 3 0 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF2530 PF10745.9 ETO26270.1 - 0.34 11.2 2.1 5.8 7.2 0.1 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2530) DUF5326 PF17260.2 ETO26270.1 - 0.89 9.7 0.0 0.89 9.7 0.0 3.8 4 0 0 4 4 4 0 Family of unknown function (DUF5326) DUF4381 PF14316.6 ETO26270.1 - 1.1 9.5 5.6 20 5.4 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4381) Pkinase_Tyr PF07714.17 ETO26271.1 - 2.7e-42 144.8 0.0 4e-42 144.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO26271.1 - 5.6e-25 88.2 0.0 9.7e-25 87.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO26271.1 - 0.00015 20.7 1.4 0.0003 19.7 0.0 2.0 2 0 0 2 2 2 1 Fungal protein kinase Connexin PF00029.19 ETO26271.1 - 0.32 10.7 2.3 28 4.4 2.0 2.2 2 0 0 2 2 2 0 Connexin Pox_Ag35 PF03286.14 ETO26271.1 - 7.5 6.3 10.4 2.3 8.0 5.2 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 ETO26272.1 - 0.12 12.8 4.1 0.22 11.9 4.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Adeno_PV PF03910.13 ETO26272.1 - 0.87 8.2 2.0 2.3 6.8 2.0 1.6 1 1 0 1 1 1 0 Adenovirus minor core protein PV DUF5364 PF17322.2 ETO26273.1 - 0.43 10.9 25.8 0.82 9.9 25.8 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5364) LAP1C PF05609.12 ETO26273.1 - 1.3 8.0 15.9 1.6 7.8 15.9 1.0 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) E7 PF00527.18 ETO26274.1 - 0.12 12.6 1.8 0.3 11.3 1.8 1.7 1 0 0 1 1 1 0 E7 protein, Early protein SET PF00856.28 ETO26275.1 - 7.1e-07 29.8 0.2 7.1e-07 29.8 0.2 2.5 2 1 0 2 2 2 1 SET domain DUF3464 PF11947.8 ETO26275.1 - 0.3 10.8 3.4 0.13 12.0 0.2 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Zip PF02535.22 ETO26275.1 - 0.9 8.7 3.0 1.6 7.8 3.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4175 PF13779.6 ETO26275.1 - 1.8 6.4 5.3 2.6 5.8 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Arf PF00025.21 ETO26276.1 - 4.7e-45 153.2 5.1 4.2e-29 101.2 0.5 4.1 2 1 0 3 3 3 3 ADP-ribosylation factor family G-alpha PF00503.20 ETO26276.1 - 2.6e-06 26.8 0.6 0.00023 20.5 0.1 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Roc PF08477.13 ETO26276.1 - 6.7e-06 26.3 1.2 0.0097 16.1 0.1 3.7 2 1 2 4 4 4 2 Ras of Complex, Roc, domain of DAPkinase SRPRB PF09439.10 ETO26276.1 - 1.6e-05 24.4 0.1 0.0013 18.3 0.1 3.0 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit Ras PF00071.22 ETO26276.1 - 0.00066 19.3 0.1 0.019 14.5 0.0 3.0 2 1 1 3 3 3 1 Ras family Gtr1_RagA PF04670.12 ETO26276.1 - 0.022 14.1 0.3 3.3 7.0 0.0 2.8 2 1 1 3 3 3 0 Gtr1/RagA G protein conserved region zf-C3HC4_3 PF13920.6 ETO26277.1 - 2.7e-13 49.5 9.2 4.7e-13 48.8 9.2 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO26277.1 - 1.1e-09 38.0 9.7 2.3e-09 37.0 9.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ETO26277.1 - 7.4e-05 22.6 9.2 0.00016 21.6 9.2 1.6 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETO26277.1 - 0.00071 19.9 11.6 0.0016 18.7 11.6 1.7 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO26277.1 - 0.0013 18.5 13.5 0.0037 17.1 13.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO26277.1 - 0.0017 18.1 14.0 0.0046 16.8 14.0 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) CG-1 PF03859.16 ETO26277.1 - 0.0048 16.7 0.6 0.009 15.8 0.6 1.4 1 0 0 1 1 1 1 CG-1 domain PHM7_cyt PF14703.6 ETO26277.1 - 0.064 13.5 5.2 0.14 12.3 1.5 2.3 2 0 0 2 2 2 0 Cytosolic domain of 10TM putative phosphate transporter zf-C3H2C3 PF17122.5 ETO26277.1 - 0.3 11.2 6.5 0.6 10.2 6.5 1.5 1 0 0 1 1 1 0 Zinc-finger zf-RING_UBOX PF13445.6 ETO26277.1 - 0.4 10.8 7.8 1.2 9.2 7.8 1.8 1 1 0 1 1 1 0 RING-type zinc-finger Syntaxin-6_N PF09177.11 ETO26277.1 - 0.45 11.1 0.0 0.45 11.1 0.0 2.9 2 1 0 2 2 2 0 Syntaxin 6, N-terminal GrpE PF01025.19 ETO26277.1 - 0.47 10.1 7.3 0.99 9.1 1.6 2.4 2 0 0 2 2 2 0 GrpE MerR-DNA-bind PF09278.11 ETO26277.1 - 0.8 10.3 5.3 0.54 10.8 0.6 2.8 3 0 0 3 3 3 0 MerR, DNA binding HSCB_C PF07743.13 ETO26277.1 - 2.2 8.9 13.0 3.2 8.3 1.5 2.7 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain TMF_TATA_bd PF12325.8 ETO26277.1 - 2.9 8.2 14.8 1.9 8.7 0.1 2.9 3 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding ABC_tran_Xtn PF12848.7 ETO26277.1 - 3.4 7.8 10.5 1.9 8.6 4.3 2.5 2 0 0 2 2 2 0 ABC transporter DUF4140 PF13600.6 ETO26277.1 - 3.7 8.1 5.4 9.5 6.7 0.1 2.6 3 0 0 3 3 2 0 N-terminal domain of unknown function (DUF4140) Utp14 PF04615.13 ETO26279.1 - 0.018 13.7 19.4 0.023 13.3 19.4 1.1 1 0 0 1 1 1 0 Utp14 protein CDC45 PF02724.14 ETO26279.1 - 0.38 9.0 17.4 0.0059 15.0 9.2 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF4407 PF14362.6 ETO26279.1 - 1.6 8.0 5.4 2.2 7.5 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Mem_trans PF03547.18 ETO26279.1 - 4.4 5.6 5.6 5 5.4 5.6 1.2 1 0 0 1 1 1 0 Membrane transport protein NPR3 PF03666.13 ETO26279.1 - 6.7 5.4 24.6 0.23 10.2 17.7 1.9 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 TAF6_C PF07571.13 ETO26280.1 - 0.0042 17.4 0.1 0.019 15.3 0.0 2.1 2 1 0 2 2 2 1 TAF6 C-terminal HEAT repeat domain CSG2 PF16965.5 ETO26280.1 - 0.073 12.0 0.5 0.11 11.4 0.5 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Secretin_N_2 PF07655.13 ETO26280.1 - 0.18 12.4 9.9 0.39 11.3 9.9 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain C_GCAxxG_C_C PF09719.10 ETO26280.1 - 0.32 11.3 4.4 3.9 7.8 0.0 2.9 1 1 1 2 2 2 0 Putative redox-active protein (C_GCAxxG_C_C) Glutaminase PF04960.15 ETO26283.1 - 0.022 13.9 0.5 0.041 13.1 0.5 1.3 1 0 0 1 1 1 0 Glutaminase DUF3959 PF13105.6 ETO26283.1 - 3.1 7.3 7.2 7.3 6.0 2.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3959) MafB19-deam PF14437.6 ETO26286.1 - 1.9e-21 76.2 0.8 2.6e-21 75.8 0.8 1.2 1 0 0 1 1 1 1 MafB19-like deaminase dCMP_cyt_deam_1 PF00383.23 ETO26286.1 - 8.7e-21 73.7 6.4 1.5e-20 73.0 6.4 1.3 1 0 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region SNAD4 PF18750.1 ETO26286.1 - 0.0031 17.6 1.7 0.0057 16.8 1.7 1.4 1 0 0 1 1 1 1 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC2 PF18772.1 ETO26286.1 - 0.0099 15.9 0.5 0.014 15.5 0.5 1.2 1 0 0 1 1 1 1 APOBEC2 APOBEC3 PF18771.1 ETO26286.1 - 0.036 14.2 0.3 0.05 13.7 0.3 1.3 1 0 0 1 1 1 0 APOBEC3 NAD1 PF18778.1 ETO26286.1 - 0.051 13.7 0.9 0.075 13.1 0.9 1.3 1 0 0 1 1 1 0 Novel AID APOBEC clade 1 APOBEC_N PF08210.11 ETO26286.1 - 0.056 13.3 1.1 0.076 12.9 1.1 1.3 1 0 0 1 1 1 0 APOBEC-like N-terminal domain APOBEC4_like PF18774.1 ETO26286.1 - 0.092 12.7 2.6 0.14 12.1 2.3 1.4 1 1 0 1 1 1 0 APOBEC4-like -AID/APOBEC-deaminase Bd3614-deam PF14439.6 ETO26286.1 - 0.14 12.2 3.4 0.32 11.1 3.3 1.6 1 1 0 1 1 1 0 Bd3614-like deaminase Npa1 PF11707.8 ETO26287.1 - 0.13 11.6 0.0 0.21 10.9 0.0 1.2 1 0 0 1 1 1 0 Ribosome 60S biogenesis N-terminal Tektin PF03148.14 ETO26288.1 - 0.012 14.4 0.2 0.015 14.0 0.2 1.2 1 0 0 1 1 1 0 Tektin family Atg14 PF10186.9 ETO26288.1 - 0.055 12.5 1.3 0.059 12.5 1.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 V-SNARE PF05008.15 ETO26288.1 - 0.095 13.1 2.9 0.21 12.0 2.9 1.7 1 1 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus MtrG PF04210.13 ETO26288.1 - 0.22 11.4 0.9 0.78 9.6 0.3 2.0 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G V-SNARE_C PF12352.8 ETO26289.1 - 1.2e-11 44.7 16.1 5.5e-06 26.6 4.6 2.8 3 0 0 3 3 2 2 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO26289.1 - 6.1e-11 42.1 9.0 3.1e-05 23.8 0.6 3.2 3 0 0 3 3 3 2 Sec20 DUF3040 PF11239.8 ETO26289.1 - 0.0035 17.6 0.3 0.15 12.3 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF3040) Use1 PF09753.9 ETO26289.1 - 0.0064 16.3 18.6 0.018 14.8 8.3 2.5 2 1 0 2 2 2 2 Membrane fusion protein Use1 HIP1_clath_bdg PF16515.5 ETO26289.1 - 0.025 15.2 18.2 0.14 12.8 1.3 3.3 2 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 MgtE PF01769.16 ETO26289.1 - 0.065 13.6 6.4 0.48 10.8 2.6 2.3 2 0 0 2 2 2 0 Divalent cation transporter MCU PF04678.13 ETO26289.1 - 0.13 12.4 7.0 4.5 7.3 0.2 3.1 3 0 0 3 3 3 0 Mitochondrial calcium uniporter NPV_P10 PF05531.12 ETO26289.1 - 0.21 12.0 11.3 6 7.4 0.9 3.7 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Laminin_II PF06009.12 ETO26289.1 - 0.23 11.5 11.4 1.2 9.2 0.3 3.3 3 0 0 3 3 3 0 Laminin Domain II Bcr-Abl_Oligo PF09036.10 ETO26289.1 - 0.3 11.1 1.8 17 5.5 0.2 3.2 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain TPPK_C PF12555.8 ETO26289.1 - 0.35 10.9 3.4 3.5 7.7 0.2 2.3 2 0 0 2 2 2 0 Thiamine pyrophosphokinase C terminal DUF2703 PF10865.8 ETO26289.1 - 0.93 9.7 4.6 2 8.6 0.6 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF2703) Synaptobrevin PF00957.21 ETO26289.1 - 1.4 8.8 20.8 3.5 7.5 2.6 3.9 3 1 0 3 3 3 0 Synaptobrevin NnrS PF05940.12 ETO26289.1 - 1.8 7.9 7.0 1.6 8.0 3.7 1.9 2 0 0 2 2 2 0 NnrS protein Uds1 PF15456.6 ETO26289.1 - 7.9 6.7 9.9 14 5.8 1.2 2.6 2 1 0 2 2 2 0 Up-regulated During Septation Med9 PF07544.13 ETO26289.1 - 8.9 6.5 9.0 4.1 7.6 0.2 3.5 4 0 0 4 4 3 0 RNA polymerase II transcription mediator complex subunit 9 Luteo_coat PF00894.18 ETO26290.1 - 0.64 9.9 5.7 0.1 12.5 0.6 2.3 3 0 0 3 3 3 0 Luteovirus coat protein AgrB PF04647.15 ETO26291.1 - 0.016 14.5 1.7 0.1 11.9 0.2 2.0 2 0 0 2 2 2 0 Accessory gene regulator B PTR2 PF00854.21 ETO26291.1 - 0.037 12.9 1.8 0.036 12.9 0.7 1.4 1 1 0 1 1 1 0 POT family Bac_luciferase PF00296.20 ETO26292.1 - 0.022 14.2 0.1 0.028 13.9 0.1 1.1 1 0 0 1 1 1 0 Luciferase-like monooxygenase CBP4 PF07960.11 ETO26293.1 - 0.014 15.2 1.8 0.024 14.5 1.8 1.3 1 0 0 1 1 1 0 CBP4 Elicitin PF00964.17 ETO26293.1 - 0.068 13.3 0.8 0.78 9.9 0.1 2.2 2 0 0 2 2 2 0 Elicitin RRM_1 PF00076.22 ETO26294.1 - 7.4e-24 83.4 0.0 1.8e-14 53.3 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Atrophin-1 PF03154.15 ETO26294.1 - 0.0011 17.4 15.2 0.0011 17.4 15.2 1.6 2 0 0 2 2 2 1 Atrophin-1 family DUF3737 PF12541.8 ETO26294.1 - 0.0051 16.1 0.2 0.0072 15.6 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3737) Connexin PF00029.19 ETO26294.1 - 0.16 11.7 1.0 4.7 6.9 0.3 2.2 2 0 0 2 2 2 0 Connexin BRF1 PF07741.13 ETO26294.1 - 0.32 11.4 8.3 0.49 10.8 1.8 2.7 2 1 0 2 2 2 0 Brf1-like TBP-binding domain FAM176 PF14851.6 ETO26294.1 - 0.45 10.2 8.4 6.6 6.4 0.0 2.2 2 0 0 2 2 2 0 FAM176 family RSB_motif PF16294.5 ETO26294.1 - 1.6 9.0 24.0 2.2 8.6 17.9 2.4 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif TMEM51 PF15345.6 ETO26294.1 - 1.6 8.5 7.4 0.66 9.8 0.1 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 Trypan_PARP PF05887.11 ETO26294.1 - 1.8 8.6 4.6 0.24 11.4 0.3 1.6 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) tRNA-synt_1c PF00749.21 ETO26295.1 - 1.6e-66 224.3 1.7 1.8e-39 135.5 0.0 3.1 3 0 0 3 3 3 3 tRNA synthetases class I (E and Q), catalytic domain tRNA-synt_1c_C PF03950.18 ETO26295.1 - 3.5e-23 82.4 0.1 5.8e-23 81.6 0.1 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (E and Q), anti-codon binding domain TPP1 PF10341.9 ETO26297.1 - 0.0014 18.6 2.0 0.0015 18.5 0.3 2.1 2 0 0 2 2 2 1 Shelterin complex subunit, TPP1/ACD RPEL PF02755.15 ETO26298.1 - 2.3e-12 46.2 13.7 0.00018 21.1 1.2 6.1 5 0 0 5 5 5 5 RPEL repeat Trnau1ap PF17654.1 ETO26300.1 - 0.017 15.9 0.5 1.9 9.4 0.0 2.2 2 0 0 2 2 2 0 Selenocysteine tRNA 1 associated proteins YniB PF14002.6 ETO26300.1 - 0.059 13.1 0.2 0.17 11.7 0.0 1.7 2 0 0 2 2 2 0 YniB-like protein GNVR PF13807.6 ETO26300.1 - 0.06 13.3 1.7 0.075 13.0 0.1 1.9 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase AAA_lid_6 PF17866.1 ETO26300.1 - 0.078 13.2 0.3 0.18 12.0 0.3 1.7 2 0 0 2 2 2 0 AAA lid domain DUF2985 PF11204.8 ETO26300.1 - 0.088 13.0 0.2 1.1 9.5 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2985) WWE PF02825.20 ETO26301.1 - 1.3e-08 35.2 0.8 1.3e-08 35.2 0.8 2.9 3 0 0 3 3 3 1 WWE domain PABP PF00658.18 ETO26301.1 - 4.7e-07 29.9 0.1 1.4e-06 28.4 0.1 1.8 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-CCCH PF00642.24 ETO26301.1 - 0.0026 17.7 1.6 0.0026 17.7 1.6 3.2 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) GAT PF03127.14 ETO26301.1 - 0.1 12.9 1.8 0.43 10.9 0.7 2.5 2 0 0 2 2 2 0 GAT domain Pox_Ag35 PF03286.14 ETO26302.1 - 0.082 12.7 5.6 0.097 12.4 5.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SURF2 PF05477.11 ETO26302.1 - 0.31 10.7 3.3 0.33 10.6 3.3 1.0 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) DNA_pol_phi PF04931.13 ETO26302.1 - 1.8 6.5 11.6 2.2 6.2 11.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi PPR_2 PF13041.6 ETO26303.1 - 4.3e-14 52.4 2.7 2.1e-09 37.5 0.0 3.9 3 0 0 3 3 3 2 PPR repeat family PPR PF01535.20 ETO26303.1 - 2.3e-11 43.1 6.3 0.00031 20.8 0.1 4.9 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 ETO26303.1 - 6.8e-08 32.5 1.4 3.9e-05 23.6 0.1 3.9 3 1 1 4 4 4 1 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO26303.1 - 5.3e-05 22.8 1.4 0.014 15.1 0.0 3.4 3 0 0 3 3 3 1 PPR repeat ATP13 PF12921.7 ETO26303.1 - 0.0038 17.1 0.1 1.5 8.7 0.0 2.6 1 1 1 2 2 2 2 Mitochondrial ATPase expression Surp PF01805.20 ETO26303.1 - 0.14 12.2 0.5 14 5.7 0.0 3.1 3 0 0 3 3 3 0 Surp module RPEL PF02755.15 ETO26304.1 - 0.00037 20.1 20.8 0.17 11.6 0.6 7.2 7 0 0 7 7 7 4 RPEL repeat ECM11 PF15463.6 ETO26304.1 - 0.012 16.2 2.2 0.012 16.2 2.2 4.0 3 1 1 4 4 4 0 Extracellular mutant protein 11 SAP PF02037.27 ETO26305.1 - 0.011 15.5 3.0 0.023 14.4 0.4 2.4 2 0 0 2 2 2 0 SAP domain DUF4167 PF13763.6 ETO26307.1 - 0.093 12.9 0.2 0.093 12.9 0.2 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4167) HALZ PF02183.18 ETO26307.1 - 0.12 12.7 0.2 0.12 12.7 0.2 5.4 4 1 0 4 4 4 0 Homeobox associated leucine zipper Frizzled PF01534.17 ETO26307.1 - 0.62 9.0 5.0 0.96 8.4 0.2 2.4 3 0 0 3 3 3 0 Frizzled/Smoothened family membrane region Fungal_trans_2 PF11951.8 ETO26307.1 - 0.7 8.6 6.6 0.37 9.5 3.5 2.1 3 0 0 3 3 3 0 Fungal specific transcription factor domain SARAF PF06682.12 ETO26307.1 - 0.76 9.4 11.1 0.055 13.1 4.6 2.3 1 1 2 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis DUF1515 PF07439.11 ETO26307.1 - 0.99 9.5 14.2 0.17 11.9 0.4 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF1515) DUF948 PF06103.11 ETO26307.1 - 1 9.7 5.9 4.8 7.5 0.1 4.1 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) Peptidase_M15_2 PF05951.13 ETO26307.1 - 1.7 8.3 5.2 19 4.9 0.8 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF882) ATP-synt_8 PF00895.20 ETO26307.1 - 3.2 8.3 7.0 0.96 10.0 0.7 3.3 3 0 0 3 3 3 0 ATP synthase protein 8 ApoO PF09769.9 ETO26307.1 - 4.9 7.1 8.1 3.7 7.5 0.7 3.2 2 1 1 3 3 3 0 Apolipoprotein O HMMR_N PF15905.5 ETO26308.1 - 0.00042 19.9 4.8 0.00093 18.8 4.8 1.5 1 0 0 1 1 1 1 Hyaluronan mediated motility receptor N-terminal DUF5094 PF17015.5 ETO26308.1 - 0.0039 17.3 0.3 0.0039 17.3 0.3 3.2 1 1 1 3 3 3 1 Domain of unknown function (DUF5094) FlaC_arch PF05377.11 ETO26308.1 - 0.0084 16.5 2.6 0.046 14.1 2.6 2.2 1 1 0 1 1 1 1 Flagella accessory protein C (FlaC) ALMT PF11744.8 ETO26308.1 - 0.12 11.1 4.2 0.17 10.7 4.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter NAD_binding_1 PF00175.21 ETO26308.1 - 0.13 12.9 0.2 0.24 12.1 0.2 1.4 1 0 0 1 1 1 0 Oxidoreductase NAD-binding domain TolA_bind_tri PF16331.5 ETO26308.1 - 4.8 7.3 18.3 0.096 12.8 10.9 1.9 2 0 0 2 2 2 0 TolA binding protein trimerisation Bap31_Bap29_C PF18035.1 ETO26308.1 - 6.1 6.9 10.5 88 3.2 2.3 2.4 1 1 1 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Senescence PF06911.12 ETO26309.1 - 0.022 15.1 0.1 0.14 12.5 0.1 1.8 2 0 0 2 2 2 0 Senescence-associated protein FANCI_S3 PF14677.6 ETO26309.1 - 0.039 13.7 0.8 0.064 12.9 0.1 1.7 2 0 0 2 2 2 0 FANCI solenoid 3 Synuclein PF01387.17 ETO26309.1 - 0.086 13.1 1.0 0.18 12.0 1.0 1.5 1 0 0 1 1 1 0 Synuclein ProRS-C_1 PF09180.11 ETO26309.1 - 0.19 12.0 2.1 0.35 11.1 2.1 1.4 1 0 0 1 1 1 0 Prolyl-tRNA synthetase, C-terminal Colipase-like PF15083.6 ETO26309.1 - 0.36 11.0 5.5 1.8 8.8 0.7 2.3 1 1 1 2 2 2 0 Colipase-like IL32 PF15225.6 ETO26309.1 - 0.76 10.2 4.0 0.85 10.0 1.8 2.1 1 1 1 2 2 2 0 Interleukin 32 Vps39_2 PF10367.9 ETO26310.1 - 0.032 14.7 1.5 0.058 13.8 0.2 2.0 1 1 1 2 2 2 0 Vacuolar sorting protein 39 domain 2 Mfa2 PF08842.10 ETO26310.1 - 0.065 12.8 0.0 0.08 12.5 0.0 1.1 1 0 0 1 1 1 0 Fimbrillin-A associated anchor proteins Mfa1 and Mfa2 FapA PF03961.13 ETO26310.1 - 0.065 11.8 0.2 0.075 11.6 0.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A UPF0547 PF10571.9 ETO26310.1 - 0.11 12.6 0.3 1.9 8.6 0.1 2.2 2 0 0 2 2 2 0 Uncharacterised protein family UPF0547 zf-C3HC4_2 PF13923.6 ETO26310.1 - 0.29 11.0 1.2 14 5.6 0.1 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Clathrin PF00637.20 ETO26311.1 - 2e-07 31.0 0.3 1.7e-05 24.7 0.0 2.6 2 1 0 2 2 2 1 Region in Clathrin and VPS MA3 PF02847.17 ETO26311.1 - 0.093 12.7 1.0 0.85 9.6 0.0 2.8 3 0 0 3 3 3 0 MA3 domain CBM_4_9 PF02018.17 ETO26311.1 - 0.13 12.5 0.5 0.43 10.8 0.1 2.0 2 0 0 2 2 2 0 Carbohydrate binding domain TPR_19 PF14559.6 ETO26311.1 - 0.13 12.8 0.0 16 6.1 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat Pep3_Vps18 PF05131.14 ETO26312.1 - 2e-16 60.1 1.2 3e-16 59.6 1.2 1.3 1 0 0 1 1 1 1 Pep3/Vps18/deep orange family CDC50 PF03381.15 ETO26312.1 - 0.011 15.2 0.7 0.011 15.2 0.7 1.7 2 0 0 2 2 2 0 LEM3 (ligand-effect modulator 3) family / CDC50 family TPR_2 PF07719.17 ETO26312.1 - 0.4 10.9 2.8 3.1 8.1 0.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat YIF1 PF03878.15 ETO26313.1 - 1e-48 165.9 6.9 2.8e-48 164.5 6.9 1.6 1 1 0 1 1 1 1 YIF1 Yip1 PF04893.17 ETO26313.1 - 0.054 13.2 14.6 0.029 14.1 11.8 2.0 2 1 0 2 2 2 0 Yip1 domain KcnmB2_inactiv PF09303.10 ETO26313.1 - 0.87 9.4 2.7 2 8.3 2.7 1.6 1 0 0 1 1 1 0 KCNMB2, ball and chain domain ADP_ribosyl_GH PF03747.14 ETO26314.1 - 3.2e-22 79.6 0.0 4.9e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase WD40 PF00400.32 ETO26316.1 - 3.2e-09 37.3 4.9 0.018 15.9 0.0 4.8 5 0 0 5 5 4 2 WD domain, G-beta repeat Spc7 PF08317.11 ETO26316.1 - 4.8e-06 25.7 18.2 4.8e-06 25.7 18.2 5.8 2 2 3 6 6 6 3 Spc7 kinetochore protein Atg14 PF10186.9 ETO26316.1 - 9.4e-06 24.9 25.6 9.4e-06 24.9 25.6 5.1 1 1 2 4 4 3 1 Vacuolar sorting 38 and autophagy-related subunit 14 ANAPC4_WD40 PF12894.7 ETO26316.1 - 0.00079 19.7 0.0 0.47 10.8 0.0 4.4 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain CENP-F_leu_zip PF10473.9 ETO26316.1 - 0.001 19.1 14.0 0.001 19.1 14.0 6.6 2 2 3 6 6 4 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 SlyX PF04102.12 ETO26316.1 - 0.002 18.7 2.0 0.002 18.7 2.0 10.1 5 3 5 10 10 9 2 SlyX HMMR_N PF15905.5 ETO26316.1 - 0.0021 17.6 32.5 0.0021 17.6 32.5 5.0 2 2 2 4 4 4 2 Hyaluronan mediated motility receptor N-terminal TPR_MLP1_2 PF07926.12 ETO26316.1 - 0.0023 18.0 113.5 0.03 14.4 14.1 7.1 3 1 3 7 7 7 4 TPR/MLP1/MLP2-like protein TMF_TATA_bd PF12325.8 ETO26316.1 - 0.0034 17.6 13.5 0.0034 17.6 13.5 8.0 1 1 5 7 7 6 1 TATA element modulatory factor 1 TATA binding DMPK_coil PF08826.10 ETO26316.1 - 0.0046 17.0 12.2 0.0046 17.0 12.2 8.4 7 2 2 9 9 7 1 DMPK coiled coil domain like Lebercilin PF15619.6 ETO26316.1 - 0.0066 16.1 32.4 0.0066 16.1 32.4 6.0 4 2 1 5 5 4 3 Ciliary protein causing Leber congenital amaurosis disease ATG16 PF08614.11 ETO26316.1 - 0.01 16.0 33.5 0.01 16.0 33.5 6.5 2 1 5 7 7 5 0 Autophagy protein 16 (ATG16) Tropomyosin_1 PF12718.7 ETO26316.1 - 0.011 15.9 32.3 0.011 15.9 32.3 7.2 2 2 4 6 6 3 0 Tropomyosin like DUF4677 PF15726.5 ETO26316.1 - 0.1 12.7 0.8 14 5.8 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4677) REV PF00424.18 ETO26316.1 - 0.27 11.3 4.5 0.38 10.8 0.2 2.8 2 0 0 2 2 2 0 REV protein (anti-repression trans-activator protein) Filament PF00038.21 ETO26316.1 - 0.78 9.3 105.6 0.041 13.5 19.2 5.4 2 2 3 5 5 5 0 Intermediate filament protein Baculo_PEP_C PF04513.12 ETO26316.1 - 1.2 9.2 66.7 0.013 15.5 11.1 6.0 2 2 2 6 6 6 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3584 PF12128.8 ETO26316.1 - 1.4 6.3 99.3 0.089 10.3 50.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) GAS PF13851.6 ETO26316.1 - 3 7.1 125.3 0.039 13.3 15.0 6.9 2 1 5 7 7 5 0 Growth-arrest specific micro-tubule binding WD40 PF00400.32 ETO26317.1 - 5.7e-58 191.5 13.0 1.5e-11 44.6 0.1 6.5 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26317.1 - 1.3e-20 73.4 1.3 0.0025 18.1 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26317.1 - 6.8e-18 64.7 2.1 0.013 14.5 0.0 6.7 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO26317.1 - 4.3e-10 38.9 1.9 0.025 13.2 0.0 4.3 1 1 2 4 4 4 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO26317.1 - 2.7e-09 37.2 0.0 0.0012 18.7 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO26317.1 - 6.3e-08 32.3 0.1 0.011 15.1 0.0 2.5 1 1 1 2 2 2 2 WD40-like domain Nbas_N PF15492.6 ETO26317.1 - 1.9e-05 24.1 0.4 0.66 9.3 0.0 4.0 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO26317.1 - 0.00012 20.7 1.4 0.03 12.8 0.0 3.1 1 1 2 3 3 3 1 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO26317.1 - 0.017 15.2 0.5 4.4 7.4 0.0 3.8 1 1 3 4 4 4 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO26317.1 - 0.018 15.0 6.9 66 3.6 0.0 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO26317.1 - 0.021 13.6 3.8 2 7.1 0.3 4.1 1 1 3 4 4 4 0 Nup133 N terminal like Gmad1 PF10647.9 ETO26317.1 - 0.049 13.4 0.2 13 5.4 0.0 2.6 1 1 2 3 3 3 0 Lipoprotein LpqB beta-propeller domain PARP PF00644.20 ETO26318.1 - 9.9e-06 25.3 0.6 3.7e-05 23.4 0.0 2.2 3 0 0 3 3 3 1 Poly(ADP-ribose) polymerase catalytic domain WWE PF02825.20 ETO26318.1 - 0.036 14.7 0.3 0.036 14.7 0.3 1.9 2 0 0 2 2 2 0 WWE domain PH_10 PF15411.6 ETO26318.1 - 0.54 10.5 4.5 0.17 12.2 0.3 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain PsbQ PF05757.11 ETO26319.1 - 0.056 13.2 0.1 0.13 12.0 0.1 1.5 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) Presenilin PF01080.17 ETO26319.1 - 5.6 5.6 5.1 8.3 5.1 5.1 1.3 1 0 0 1 1 1 0 Presenilin DivIVA PF05103.13 ETO26321.1 - 0.11 12.6 1.1 0.18 11.9 1.1 1.3 1 0 0 1 1 1 0 DivIVA protein His_Phos_1 PF00300.22 ETO26322.1 - 7.1e-24 84.6 0.5 1.7e-23 83.4 0.5 1.5 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) His_Phos_2 PF00328.22 ETO26322.1 - 0.00091 18.7 0.0 0.001 18.5 0.0 1.2 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF4346 PF14251.6 ETO26322.1 - 0.0048 16.9 0.1 0.01 15.9 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4346) RraB PF06877.11 ETO26322.1 - 0.018 15.8 0.1 0.033 14.9 0.1 1.4 1 0 0 1 1 1 0 Regulator of ribonuclease activity B NAD_binding_6 PF08030.12 ETO26323.1 - 5.8e-09 36.2 0.7 0.00046 20.3 0.0 3.1 2 1 1 3 3 3 3 Ferric reductase NAD binding domain AAA PF00004.29 ETO26325.1 - 5.3e-31 107.8 0.4 7.1e-29 100.9 0.4 2.6 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ETO26325.1 - 9.4e-08 32.0 0.1 6.4e-07 29.3 0.0 2.3 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ETO26325.1 - 7.4e-07 28.9 0.2 2e-06 27.5 0.0 1.8 2 0 0 2 2 2 1 AAA+ lid domain AAA_5 PF07728.14 ETO26325.1 - 0.0001 22.3 0.5 0.0017 18.3 0.5 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO26325.1 - 0.001 18.6 1.1 0.031 13.8 0.0 2.7 2 0 0 2 2 2 1 P-loop containing dynein motor region Mg_chelatase PF01078.21 ETO26325.1 - 0.0039 16.6 0.0 0.0078 15.6 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ETO26325.1 - 0.0042 17.5 0.2 0.013 15.9 0.2 1.8 1 1 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 ETO26325.1 - 0.011 15.4 0.3 0.12 12.1 0.3 2.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_19 PF13245.6 ETO26325.1 - 0.018 15.4 0.0 0.037 14.4 0.0 1.7 1 1 0 1 1 1 0 AAA domain AAA_2 PF07724.14 ETO26325.1 - 0.022 14.9 0.0 0.081 13.0 0.0 1.9 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO26325.1 - 0.024 14.9 0.1 0.11 12.8 0.0 2.2 1 1 1 2 2 2 0 AAA domain AFG1_ATPase PF03969.16 ETO26325.1 - 0.052 12.4 0.0 0.088 11.7 0.0 1.3 1 0 0 1 1 1 0 AFG1-like ATPase AAA_24 PF13479.6 ETO26325.1 - 0.085 12.6 0.2 0.19 11.5 0.2 1.8 1 1 0 1 1 1 0 AAA domain ATPase PF06745.13 ETO26325.1 - 0.087 12.2 0.7 1.9 7.8 0.2 2.7 1 1 1 2 2 2 0 KaiC IstB_IS21 PF01695.17 ETO26325.1 - 0.15 11.8 0.1 0.49 10.1 0.1 1.9 1 1 1 2 2 2 0 IstB-like ATP binding protein RuvB_N PF05496.12 ETO26325.1 - 0.18 11.5 0.6 1.3 8.8 0.1 2.4 2 1 0 2 2 2 0 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 ETO26325.1 - 0.22 11.2 1.0 0.42 10.4 0.1 2.0 2 1 0 2 2 2 0 AAA domain PTPlike_phytase PF14566.6 ETO26326.1 - 5.5e-32 111.0 0.1 7.8e-23 81.3 0.0 2.5 2 0 0 2 2 2 2 Inositol hexakisphosphate CAP_GLY PF01302.25 ETO26327.1 - 7.6e-18 64.3 0.1 1.4e-17 63.4 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain Trypan_PARP PF05887.11 ETO26327.1 - 3.6e-08 33.5 23.0 3.6e-08 33.5 23.0 2.2 2 0 0 2 2 2 1 Procyclic acidic repetitive protein (PARP) DUF2052 PF09747.9 ETO26327.1 - 0.0026 17.9 6.0 0.014 15.6 0.1 2.4 2 0 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) TonB_N PF16031.5 ETO26327.1 - 0.0045 17.5 18.9 0.0045 17.5 18.9 3.4 4 1 0 5 5 5 1 TonB polyproline region PTPRCAP PF15713.5 ETO26327.1 - 9 6.6 15.4 3.7 7.8 3.6 2.5 2 0 0 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated 7TM-7TMR_HD PF07698.11 ETO26329.1 - 0.00057 19.7 0.4 0.0011 18.7 0.4 1.5 1 0 0 1 1 1 1 7TM receptor with intracellular HD hydrolase 7tm_3 PF00003.22 ETO26329.1 - 0.0015 18.4 1.1 0.0015 18.4 1.1 1.5 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4834 PF16118.5 ETO26329.1 - 0.032 15.2 3.1 0.064 14.2 2.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DUF2681 PF10883.8 ETO26329.1 - 0.04 14.3 13.4 0.095 13.1 13.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) RskA PF10099.9 ETO26329.1 - 0.058 13.7 0.0 0.077 13.3 0.0 1.1 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Spt20 PF12090.8 ETO26329.1 - 0.068 12.8 21.3 0.091 12.4 21.3 1.1 1 0 0 1 1 1 0 Spt20 family CLN3 PF02487.17 ETO26329.1 - 0.089 11.8 2.9 0.064 12.3 1.1 1.5 1 1 1 2 2 2 0 CLN3 protein MscS_TM PF12794.7 ETO26329.1 - 0.11 11.4 4.8 0.19 10.5 4.8 1.4 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 TFIIA PF03153.13 ETO26329.1 - 1.1 9.1 16.4 1.5 8.8 16.4 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Wzy_C_2 PF11846.8 ETO26329.1 - 2.2 8.2 12.7 7.4 6.4 4.9 2.2 1 1 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal DUF4407 PF14362.6 ETO26329.1 - 3.3 7.0 7.7 5.2 6.3 7.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FTZ PF03867.14 ETO26329.1 - 4 6.9 10.0 5.8 6.4 10.0 1.2 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DUF2722 PF10846.8 ETO26329.1 - 4.1 6.3 18.0 5.3 5.9 18.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) TPR_2 PF07719.17 ETO26330.1 - 1.2e-17 62.6 21.5 0.0099 15.9 0.8 8.0 7 1 1 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26330.1 - 9.6e-14 50.4 20.8 0.19 12.0 0.1 7.8 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26330.1 - 1.6e-11 44.3 16.7 0.013 15.8 0.6 6.1 3 1 4 7 7 7 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO26330.1 - 7.5e-11 42.5 1.5 6.6e-07 29.9 0.1 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26330.1 - 1.2e-10 41.0 15.5 0.0009 19.5 0.7 6.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26330.1 - 6.1e-10 39.1 0.6 0.034 15.0 0.0 4.7 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26330.1 - 3.3e-09 36.3 14.3 0.00037 20.1 0.1 5.0 3 1 2 5 5 5 4 TPR repeat TPR_1 PF00515.28 ETO26330.1 - 3.8e-08 32.8 24.5 0.0046 16.7 0.1 7.7 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26330.1 - 0.0003 21.2 4.5 0.71 10.6 0.0 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat SDA1 PF05285.12 ETO26330.1 - 0.00099 18.6 27.8 0.00099 18.6 27.8 2.4 2 0 0 2 2 2 1 SDA1 DUF2722 PF10846.8 ETO26330.1 - 0.0037 16.3 5.2 0.0037 16.3 5.2 4.6 4 1 0 4 4 3 1 Protein of unknown function (DUF2722) TPR_10 PF13374.6 ETO26330.1 - 0.0084 16.0 15.6 7.6 6.6 0.1 7.1 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26330.1 - 0.012 15.5 20.0 3.2 8.0 0.0 7.2 9 0 0 9 9 7 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO26330.1 - 0.019 15.7 0.2 52 4.7 0.0 4.0 3 0 0 3 3 3 0 Sel1 repeat MIT PF04212.18 ETO26330.1 - 0.03 14.4 12.5 28 4.9 0.0 6.2 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO26330.1 - 0.051 14.1 2.6 0.44 11.1 0.0 3.5 2 1 1 4 4 4 0 Tetratricopeptide repeat DUF3492 PF11997.8 ETO26330.1 - 4.2 7.0 11.2 9.4 5.9 4.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3492) Mad3_BUB1_I PF08311.12 ETO26330.1 - 5.6 7.0 25.6 9 6.3 1.1 5.6 6 1 0 6 6 6 0 Mad3/BUB1 homology region 1 Nop14 PF04147.12 ETO26330.1 - 5.8 5.0 60.2 3.5 5.7 18.4 2.3 2 0 0 2 2 2 0 Nop14-like family Folate_carrier PF01770.18 ETO26330.1 - 8.2 5.0 13.1 0.24 10.1 5.6 2.0 2 0 0 2 2 2 0 Reduced folate carrier Hydin_ADK PF17213.3 ETO26330.1 - 8.7 6.6 7.7 2.3 8.4 2.7 2.2 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Plk4_PB2 PF18409.1 ETO26330.1 - 9.4 7.0 10.8 4.3 8.1 5.0 2.9 3 0 0 3 3 2 0 Polo-like Kinase 4 Polo Box 2 DUF913 PF06025.12 ETO26331.1 - 7.4e-18 64.7 0.0 7.4e-18 64.7 0.0 1.7 1 1 1 2 2 2 1 Domain of Unknown Function (DUF913) Protocadherin PF08374.11 ETO26331.1 - 0.033 14.2 2.4 0.051 13.6 2.4 1.3 1 0 0 1 1 1 0 Protocadherin DUF908 PF06012.12 ETO26332.1 - 0.019 14.4 0.1 0.042 13.3 0.1 1.5 1 1 0 1 1 1 0 Domain of Unknown Function (DUF908) DUF1884 PF08967.10 ETO26332.1 - 0.035 14.3 0.0 0.086 13.1 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1884) Imm71 PF15602.6 ETO26333.1 - 0.1 12.7 0.3 3 7.9 0.0 3.0 3 0 0 3 3 3 0 Immunity protein 71 DUF1474 PF07342.11 ETO26333.1 - 0.1 13.1 0.3 3.8 8.1 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1474) SH3_9 PF14604.6 ETO26334.1 - 3.8e-14 52.3 0.1 6.1e-14 51.6 0.1 1.3 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ETO26334.1 - 7.3e-14 51.1 0.1 1.2e-13 50.4 0.1 1.4 1 0 0 1 1 1 1 SH3 domain SH3_2 PF07653.17 ETO26334.1 - 1.1e-13 50.6 0.0 2e-13 49.8 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_3 PF08239.11 ETO26334.1 - 0.15 12.4 1.4 0.3 11.4 0.3 2.0 2 1 0 2 2 2 0 Bacterial SH3 domain SPRY PF00622.28 ETO26336.1 - 3.3e-13 49.8 2.0 1.2e-12 48.0 2.1 1.9 2 1 0 2 2 2 1 SPRY domain DYW_deaminase PF14432.6 ETO26337.1 - 0.1 12.4 0.5 0.35 10.8 0.2 2.0 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases Exo_endo_phos PF03372.23 ETO26338.1 - 5.2e-10 39.2 0.1 6.5e-10 38.9 0.1 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SET PF00856.28 ETO26339.1 - 1e-18 68.3 0.3 4.3e-18 66.3 0.3 1.9 1 1 0 1 1 1 1 SET domain GST_C_6 PF17171.4 ETO26339.1 - 0.04 13.7 0.7 0.071 12.9 0.0 1.7 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain WD40 PF00400.32 ETO26340.1 - 3.2e-08 34.1 5.3 1.6e-05 25.5 1.2 4.1 4 0 0 4 4 4 2 WD domain, G-beta repeat DUF2997 PF11211.8 ETO26340.1 - 0.15 11.8 0.0 0.25 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2997) zf-TRAF PF02176.18 ETO26341.1 - 2.8e-05 24.7 3.5 2.8e-05 24.7 3.5 2.4 3 0 0 3 3 3 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETO26341.1 - 0.041 13.7 2.7 0.68 9.8 2.7 2.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF4283 PF14111.6 ETO26341.1 - 0.1 12.1 0.1 0.21 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4283) Ocnus PF05005.15 ETO26342.1 - 0.093 12.9 0.5 4.8 7.4 0.1 2.3 2 0 0 2 2 2 0 Janus/Ocnus family (Ocnus) Tubulin PF00091.25 ETO26343.1 - 1.1e-63 215.0 0.0 1.5e-63 214.5 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO26343.1 - 3.5e-30 104.7 0.0 5.8e-30 104.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO26343.1 - 0.003 17.9 0.0 0.005 17.1 0.0 1.4 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ETO26343.1 - 0.016 14.4 0.0 0.025 13.8 0.0 1.2 1 0 0 1 1 1 0 Tubulin like GPS PF01825.21 ETO26344.1 - 1.1e-06 29.0 2.8 3.2e-06 27.6 2.8 1.9 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Mucin PF01456.17 ETO26344.1 - 0.018 15.0 23.5 0.061 13.3 23.5 1.9 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 ETO26344.1 - 8.9 6.3 19.3 36 4.3 19.3 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2298 PF10060.9 ETO26345.1 - 0.012 14.4 0.7 0.015 14.1 0.7 1.1 1 0 0 1 1 1 0 Uncharacterized membrane protein (DUF2298) MAP17 PF15807.5 ETO26345.1 - 0.092 13.0 0.0 0.67 10.2 0.0 2.1 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Bap31 PF05529.12 ETO26345.1 - 0.28 11.1 3.4 0.15 11.9 1.0 1.9 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region FAM176 PF14851.6 ETO26346.1 - 0.25 11.0 3.3 0.54 9.9 3.3 1.6 1 0 0 1 1 1 0 FAM176 family Sigma70_ner PF04546.13 ETO26346.1 - 0.85 9.5 7.0 1.5 8.6 7.0 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region PBP1_TM PF14812.6 ETO26346.1 - 0.99 9.8 9.8 3.2 8.2 9.8 1.8 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.9 ETO26346.1 - 2.8 7.0 16.8 0.18 10.9 11.7 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) DUF2207 PF09972.9 ETO26346.1 - 7.6 5.2 10.2 1.5 7.5 0.4 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Ras PF00071.22 ETO26349.1 - 1.2e-14 54.2 1.2 3.9e-14 52.6 0.2 1.9 2 0 0 2 2 2 1 Ras family Roc PF08477.13 ETO26349.1 - 0.0023 18.2 0.4 0.0084 16.3 0.0 2.1 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase WD40 PF00400.32 ETO26350.1 - 9.2e-50 165.6 22.0 8.5e-08 32.8 0.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26350.1 - 1.1e-12 48.0 0.7 0.0055 17.0 0.0 5.9 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO26350.1 - 6.3e-11 41.6 6.5 0.0019 16.9 0.4 5.5 3 1 2 6 6 6 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO26350.1 - 8.4e-07 29.6 1.4 3.6e-06 27.6 1.4 2.2 1 0 0 1 1 1 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO26350.1 - 0.068 13.6 2.7 0.31 11.5 2.6 2.2 1 1 0 1 1 1 0 TRAF-like zinc-finger FAM76 PF16046.5 ETO26350.1 - 0.094 12.1 10.5 0.17 11.2 10.5 1.4 1 0 0 1 1 1 0 FAM76 protein RPW8 PF05659.11 ETO26350.1 - 0.5 10.0 12.1 0.22 11.2 8.4 2.2 3 0 0 3 3 3 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 TMF_TATA_bd PF12325.8 ETO26350.1 - 0.78 10.0 16.9 1.5 9.1 16.9 1.4 1 0 0 1 1 1 0 TATA element modulatory factor 1 TATA binding DUF573 PF04504.14 ETO26350.1 - 6.3 7.5 9.2 15 6.3 9.2 1.7 1 0 0 1 1 1 0 Protein of unknown function, DUF573 Fungal_TACC PF12709.7 ETO26350.1 - 6.5 7.3 19.6 3.7 8.1 13.1 2.5 1 1 2 3 3 3 0 Fungal Transforming acidic coiled-coil (TACC) proteins YabA PF06156.13 ETO26350.1 - 9.1 7.0 19.5 5.8e+02 1.2 19.5 2.9 1 1 0 1 1 1 0 Initiation control protein YabA DUF1067 PF06362.11 ETO26352.1 - 0.12 13.2 2.4 0.16 12.7 1.2 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF1067) Mito_carr PF00153.27 ETO26355.1 - 2.2e-29 101.2 3.0 7.4e-21 73.9 0.2 2.2 2 0 0 2 2 2 2 Mitochondrial carrier protein Sec15 PF04091.12 ETO26356.1 - 4.2e-40 138.1 0.3 4.2e-39 134.8 0.3 2.3 1 1 0 1 1 1 1 Exocyst complex subunit Sec15-like DUF3439 PF11921.8 ETO26357.1 - 0.031 14.2 6.5 0.04 13.9 6.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) YL1 PF05764.13 ETO26357.1 - 3 7.9 37.6 3.3 7.7 37.6 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Spt5_N PF11942.8 ETO26357.1 - 6.5 7.8 27.1 4.7 8.2 25.8 1.4 1 1 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal CDC45 PF02724.14 ETO26357.1 - 8.5 4.5 31.5 9.3 4.4 31.5 1.1 1 0 0 1 1 1 0 CDC45-like protein OAD_gamma PF04277.13 ETO26358.1 - 2.3 8.9 5.6 0.63 10.7 1.3 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain SpoIIIAH PF12685.7 ETO26360.1 - 0.012 15.5 2.8 2.9 7.6 0.0 2.1 1 1 1 2 2 2 0 SpoIIIAH-like protein MS_channel PF00924.18 ETO26362.1 - 0.072 12.6 0.4 0.12 11.9 0.4 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel PNISR PF15996.5 ETO26362.1 - 0.52 10.6 19.5 0.72 10.1 15.4 2.0 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR GILT PF03227.16 ETO26363.1 - 5.9e-22 77.9 0.8 1.1e-21 77.1 0.8 1.6 1 1 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Menin PF05053.13 ETO26365.1 - 3.4 5.9 4.6 3.1 6.1 4.6 1.1 1 0 0 1 1 1 0 Menin EI24 PF07264.11 ETO26367.1 - 0.00038 20.7 0.2 0.00095 19.4 0.0 1.8 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) DUF2683 PF10884.8 ETO26369.1 - 0.013 15.8 0.1 0.073 13.3 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2683) Prd1-P2 PF09214.11 ETO26369.1 - 0.015 14.1 0.0 0.023 13.5 0.0 1.2 1 0 0 1 1 1 0 Bacteriophage Prd1, adsorption protein P2 GST_C_3 PF14497.6 ETO26371.1 - 3.6e-11 43.1 0.1 4.5e-11 42.8 0.1 1.1 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO26371.1 - 3.2e-06 27.3 0.0 3.9e-06 27.0 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C_2 PF13410.6 ETO26371.1 - 6.5e-06 26.1 0.0 7.3e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain Pneumo_ncap PF03246.13 ETO26371.1 - 0.0029 16.4 0.1 0.0035 16.2 0.1 1.1 1 0 0 1 1 1 1 Pneumovirus nucleocapsid protein Ribosomal_S27 PF01599.19 ETO26371.1 - 0.015 15.4 2.4 3.1 8.0 0.1 3.1 2 1 1 3 3 3 0 Ribosomal protein S27a Exostosin PF03016.15 ETO26371.1 - 0.11 11.7 0.0 0.13 11.5 0.0 1.1 1 0 0 1 1 1 0 Exostosin family TENA_THI-4 PF03070.16 ETO26371.1 - 0.13 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 TENA/THI-4/PQQC family rve_3 PF13683.6 ETO26371.1 - 0.15 11.9 0.1 0.41 10.5 0.1 1.7 2 0 0 2 2 2 0 Integrase core domain SID-1_RNA_chan PF13965.6 ETO26372.1 - 0.0043 15.5 4.0 0.0046 15.4 4.0 1.1 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 CBP_BcsG PF11658.8 ETO26372.1 - 0.032 12.6 0.5 0.032 12.6 0.5 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Mem_trans PF03547.18 ETO26372.1 - 0.15 10.4 8.3 0.18 10.2 8.3 1.2 1 0 0 1 1 1 0 Membrane transport protein Neur_chan_memb PF02932.16 ETO26372.1 - 0.29 11.2 11.9 0.42 10.6 11.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO26372.1 - 1 7.6 13.2 1.2 7.3 13.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 ETO26372.1 - 6.8 4.7 15.3 8 4.5 15.3 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein CLN3 PF02487.17 ETO26372.1 - 9.5 5.1 12.4 12 4.8 12.1 1.4 1 1 0 1 1 1 0 CLN3 protein Peptidase_C14 PF00656.22 ETO26373.1 - 5.9e-13 49.3 1.6 7.3e-13 49.0 1.6 1.1 1 0 0 1 1 1 1 Caspase domain Caleosin PF05042.13 ETO26373.1 - 0.026 14.5 0.1 0.79 9.6 0.1 2.2 2 0 0 2 2 2 0 Caleosin related protein Phage_int_SAM_4 PF13495.6 ETO26373.1 - 0.059 13.8 0.3 0.44 11.1 0.1 2.1 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain zf-TRAF PF02176.18 ETO26374.1 - 0.00036 21.2 1.7 0.00036 21.2 1.7 2.9 2 0 0 2 2 2 1 TRAF-type zinc finger Phosphoesterase PF04185.14 ETO26375.1 - 1.4e-22 80.4 0.5 5.4e-14 52.2 0.1 2.1 2 0 0 2 2 2 2 Phosphoesterase family DUF2808 PF10989.8 ETO26376.1 - 0.043 13.8 8.1 0.34 10.9 2.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2808) POTRA_2 PF08479.11 ETO26376.1 - 0.085 12.7 0.4 0.44 10.4 0.4 2.3 1 0 0 1 1 1 0 POTRA domain, ShlB-type GAS PF13851.6 ETO26376.1 - 0.13 11.6 76.8 0.14 11.5 12.2 4.9 3 2 1 4 4 4 0 Growth-arrest specific micro-tubule binding DUF2860 PF11059.8 ETO26376.1 - 0.14 11.3 3.6 0.35 10.1 3.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2860) DUF4849 PF16141.5 ETO26377.1 - 0.0084 15.4 0.2 0.01 15.1 0.2 1.1 1 0 0 1 1 1 1 Putative glycoside hydrolase Family 18, chitinase_18 Zip PF02535.22 ETO26378.1 - 0.013 14.7 4.4 0.015 14.6 4.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter SID-1_RNA_chan PF13965.6 ETO26378.1 - 0.083 11.3 0.8 0.095 11.1 0.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CobT PF06213.12 ETO26378.1 - 0.12 11.7 12.0 0.14 11.5 12.0 1.0 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TERB2 PF15101.6 ETO26378.1 - 0.26 11.3 7.0 0.31 11.1 7.0 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 DUF2052 PF09747.9 ETO26378.1 - 0.61 10.2 12.4 0.82 9.8 12.4 1.1 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Ctr PF04145.15 ETO26378.1 - 0.67 10.6 3.7 1.1 9.8 3.7 1.4 1 1 0 1 1 1 0 Ctr copper transporter family Presenilin PF01080.17 ETO26378.1 - 2 7.1 8.9 2.3 6.9 8.9 1.1 1 0 0 1 1 1 0 Presenilin CbiG_mid PF11761.8 ETO26378.1 - 2.3 8.4 4.5 3.8 7.7 4.5 1.5 1 1 0 1 1 1 0 Cobalamin biosynthesis central region RNA_pol_Rpc4 PF05132.14 ETO26378.1 - 8.8 6.8 11.8 9.6 6.6 11.4 1.3 1 1 0 1 1 1 0 RNA polymerase III RPC4 Pox_Ag35 PF03286.14 ETO26380.1 - 0.0074 16.1 1.7 0.011 15.6 1.7 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein peroxidase PF00141.23 ETO26381.1 - 7.7e-35 120.6 0.0 1.2e-34 120.0 0.0 1.3 1 1 0 1 1 1 1 Peroxidase NAPRTase_C PF17956.1 ETO26382.1 - 1.1e-28 99.8 0.6 7.6e-15 55.3 0.0 2.5 2 0 0 2 2 2 2 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ETO26382.1 - 1.4e-07 31.4 0.0 1.9e-07 30.9 0.0 1.2 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family Methyltransf_1N PF02870.15 ETO26383.1 - 7.5 7.4 13.0 42 5.1 0.2 4.8 4 0 0 4 4 4 0 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain WD40 PF00400.32 ETO26384.1 - 2.9e-11 43.7 1.5 0.0097 16.7 0.0 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26384.1 - 0.0037 17.5 0.2 0.024 14.9 0.1 2.4 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain NAPRTase_N PF17767.1 ETO26385.1 - 6.1e-46 155.9 0.5 1.5e-45 154.6 0.2 1.8 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain NAPRTase PF04095.16 ETO26385.1 - 8.2e-06 25.6 0.2 1.6e-05 24.6 0.0 1.5 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) family QRPTase_N PF02749.16 ETO26385.1 - 0.0052 16.8 0.0 0.013 15.5 0.0 1.7 1 1 1 2 2 2 1 Quinolinate phosphoribosyl transferase, N-terminal domain DUF1829 PF08862.10 ETO26385.1 - 0.015 15.8 0.4 0.03 14.8 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function DUF1829 BRE1 PF08647.11 ETO26386.1 - 0.00047 20.2 59.4 0.0038 17.3 6.3 4.3 1 1 2 4 4 4 3 BRE1 E3 ubiquitin ligase CENP-F_leu_zip PF10473.9 ETO26386.1 - 0.0006 19.8 62.7 0.057 13.4 18.7 3.4 2 1 1 3 3 3 3 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc7 PF08317.11 ETO26386.1 - 0.0017 17.3 24.9 0.0017 17.3 24.9 3.3 1 1 2 3 3 3 1 Spc7 kinetochore protein APG6_N PF17675.1 ETO26386.1 - 0.0049 17.4 63.1 0.12 12.9 6.8 4.2 1 1 3 4 4 4 2 Apg6 coiled-coil region ERM PF00769.19 ETO26386.1 - 0.0053 16.6 54.0 0.26 11.1 43.4 2.4 1 1 1 2 2 2 2 Ezrin/radixin/moesin family Seryl_tRNA_N PF02403.22 ETO26386.1 - 0.0059 16.8 53.0 0.034 14.4 5.5 4.8 1 1 4 5 5 5 3 Seryl-tRNA synthetase N-terminal domain Fez1 PF06818.15 ETO26386.1 - 0.018 15.5 52.1 0.046 14.2 22.1 3.2 1 1 2 3 3 3 0 Fez1 DUF4407 PF14362.6 ETO26386.1 - 0.019 14.3 29.3 4.4 6.6 26.6 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) EzrA PF06160.12 ETO26386.1 - 0.037 12.2 47.2 0.43 8.7 10.2 2.7 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA NPV_P10 PF05531.12 ETO26386.1 - 0.065 13.7 0.4 0.065 13.7 0.4 5.6 3 3 2 5 5 5 0 Nucleopolyhedrovirus P10 protein LPP PF04728.13 ETO26386.1 - 0.13 12.7 24.0 8 6.9 0.7 6.0 6 0 0 6 6 6 0 Lipoprotein leucine-zipper DUF4201 PF13870.6 ETO26386.1 - 0.15 11.8 51.2 0.019 14.7 14.9 3.8 1 1 2 3 3 2 0 Domain of unknown function (DUF4201) DUF2968 PF11180.8 ETO26386.1 - 0.3 10.7 36.8 0.47 10.1 4.8 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF2968) DUF1664 PF07889.12 ETO26386.1 - 0.31 11.1 38.4 0.054 13.5 2.8 4.4 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) DUF812 PF05667.11 ETO26386.1 - 0.35 9.7 55.6 0.15 10.9 32.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF812) HAP1_N PF04849.13 ETO26386.1 - 0.46 9.6 56.1 2 7.6 13.8 2.8 1 1 1 2 2 2 0 HAP1 N-terminal conserved region GAS PF13851.6 ETO26386.1 - 0.68 9.2 62.9 0.37 10.1 18.4 3.5 1 1 1 2 2 1 0 Growth-arrest specific micro-tubule binding AAA_13 PF13166.6 ETO26386.1 - 1.2 7.7 38.4 0.81 8.3 23.9 2.1 1 1 1 2 2 2 0 AAA domain ATG16 PF08614.11 ETO26386.1 - 1.4 9.1 56.7 4.3 7.5 26.5 4.2 1 1 4 5 5 5 0 Autophagy protein 16 (ATG16) SHE3 PF17078.5 ETO26386.1 - 1.6 8.4 47.5 6.5 6.4 27.5 3.0 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 IFT57 PF10498.9 ETO26386.1 - 1.9 7.3 45.1 0.081 11.9 14.2 3.1 1 1 1 3 3 3 0 Intra-flagellar transport protein 57 HSCB_C PF07743.13 ETO26386.1 - 2.4 8.7 43.2 0.14 12.7 6.3 5.7 2 1 3 5 5 5 0 HSCB C-terminal oligomerisation domain ZapB PF06005.12 ETO26386.1 - 2.8 8.5 61.6 0.79 10.2 4.8 5.4 1 1 3 4 4 3 0 Cell division protein ZapB TMF_TATA_bd PF12325.8 ETO26386.1 - 3.1 8.1 54.0 0.23 11.7 10.7 4.5 1 1 3 4 4 4 0 TATA element modulatory factor 1 TATA binding Filament PF00038.21 ETO26386.1 - 3.1 7.3 51.6 21 4.6 34.1 3.4 1 1 1 2 2 2 0 Intermediate filament protein Atg14 PF10186.9 ETO26386.1 - 3.4 6.7 47.0 2.6 7.0 5.3 3.2 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 SKA1 PF07160.12 ETO26386.1 - 6.1 6.6 36.7 0.029 14.2 11.7 2.9 1 1 2 3 3 3 0 Spindle and kinetochore-associated protein 1 YabA PF06156.13 ETO26386.1 - 7.3 7.3 48.1 2 9.1 2.5 5.1 1 1 4 5 5 5 0 Initiation control protein YabA RasGEF PF00617.19 ETO26387.1 - 5.5e-24 85.3 6.1 8.8e-22 78.1 2.3 2.8 2 1 0 2 2 2 2 RasGEF domain TrkA_N PF02254.18 ETO26387.1 - 0.12 12.6 0.0 0.25 11.6 0.0 1.4 1 0 0 1 1 1 0 TrkA-N domain MGC-24 PF05283.11 ETO26387.1 - 0.32 11.4 6.3 0.76 10.2 6.3 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Mucin PF01456.17 ETO26387.1 - 1.3 9.0 18.2 6.4 6.8 18.2 2.0 1 1 0 1 1 1 0 Mucin-like glycoprotein LMP PF04778.12 ETO26388.1 - 0.019 14.9 0.7 0.022 14.6 0.7 1.1 1 0 0 1 1 1 0 LMP repeated region TPR_12 PF13424.6 ETO26389.1 - 1.4e-08 34.9 11.6 0.27 11.6 0.1 7.1 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26389.1 - 1.7e-05 24.6 26.1 0.0008 19.3 0.4 8.8 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26389.1 - 2.3e-05 24.0 17.1 0.0002 21.0 1.2 6.1 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26389.1 - 5.5e-05 23.5 0.1 0.081 13.6 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26389.1 - 0.00016 21.5 6.9 0.044 13.8 0.1 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat PHO4 PF01384.20 ETO26389.1 - 0.078 12.0 0.0 0.078 12.0 0.0 1.1 1 0 0 1 1 1 0 Phosphate transporter family TPR_11 PF13414.6 ETO26389.1 - 0.28 10.9 4.0 9.2 6.1 0.1 4.4 5 0 0 5 5 5 0 TPR repeat TPR_8 PF13181.6 ETO26389.1 - 1.2 9.5 10.5 7.9 7.0 0.3 5.9 6 0 0 6 6 6 0 Tetratricopeptide repeat zf-TAZ PF02135.16 ETO26389.1 - 8.7 6.9 7.4 1.6 9.2 0.8 2.5 2 0 0 2 2 2 0 TAZ zinc finger PK PF00224.21 ETO26390.1 - 2.9e-05 23.1 0.5 5.1e-05 22.3 0.0 1.6 2 0 0 2 2 2 1 Pyruvate kinase, barrel domain Ubiq-Cytc-red_N PF09165.10 ETO26391.1 - 0.29 12.0 4.9 1 10.3 4.8 2.1 1 1 0 1 1 1 0 Ubiquinol-cytochrome c reductase 8 kDa, N-terminal Activator_LAG-3 PF11498.8 ETO26391.1 - 2.6 6.9 38.3 3 6.7 38.3 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 TFIIA PF03153.13 ETO26391.1 - 2.8 7.8 35.8 3.1 7.7 35.8 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Exonuc_VII_L PF02601.15 ETO26391.1 - 3 7.3 13.4 3.4 7.2 13.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Peptidase_M61 PF05299.12 ETO26391.1 - 6.7 7.1 10.1 3.4 8.1 6.4 1.9 2 0 0 2 2 2 0 M61 glycyl aminopeptidase CAP_GLY PF01302.25 ETO26392.1 - 1.5e-06 28.2 0.3 2.5e-06 27.4 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain Dehydrin PF00257.19 ETO26392.1 - 0.18 12.4 29.8 0.22 12.1 21.9 2.3 1 1 1 2 2 2 0 Dehydrin PH PF00169.29 ETO26393.1 - 3.2e-10 40.4 0.9 7.7e-10 39.2 0.9 1.7 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ETO26393.1 - 0.011 16.0 0.1 0.042 14.1 0.1 2.0 1 0 0 1 1 1 0 Pleckstrin homology domain Methyltransf_12 PF08242.12 ETO26393.1 - 0.025 15.3 3.6 0.025 15.3 3.6 3.1 3 0 0 3 3 3 0 Methyltransferase domain WD40 PF00400.32 ETO26394.1 - 1.4e-12 47.9 0.1 1.4e-05 25.7 0.0 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26394.1 - 5.2e-07 29.9 0.1 0.00077 19.7 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain tRNA-synt_1 PF00133.22 ETO26394.1 - 0.021 13.1 0.1 0.023 13.0 0.1 1.2 1 0 0 1 1 1 0 tRNA synthetases class I (I, L, M and V) SUIM_assoc PF16619.5 ETO26394.1 - 0.078 13.1 1.9 0.11 12.6 1.9 1.2 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Nup160 PF11715.8 ETO26394.1 - 0.15 10.6 0.1 2.6 6.6 0.1 1.9 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO26394.1 - 0.16 10.9 0.0 0.27 10.2 0.0 1.4 1 1 1 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein CAP_GLY PF01302.25 ETO26395.1 - 7.1e-14 51.6 0.1 1.2e-13 50.8 0.1 1.3 1 0 0 1 1 1 1 CAP-Gly domain ZapB PF06005.12 ETO26395.1 - 7e-05 23.2 1.9 0.00015 22.1 1.9 1.5 1 0 0 1 1 1 1 Cell division protein ZapB DUF1441 PF07278.11 ETO26395.1 - 0.0019 18.2 0.0 0.005 16.8 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1441) HALZ PF02183.18 ETO26395.1 - 0.012 15.8 2.9 0.031 14.5 2.9 1.8 1 0 0 1 1 1 0 Homeobox associated leucine zipper Ras PF00071.22 ETO26396.1 - 3.1e-20 72.4 0.0 8.9e-20 70.9 0.0 1.6 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO26396.1 - 4.6e-11 43.0 0.0 1.7e-10 41.1 0.0 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO26396.1 - 0.0051 16.3 0.0 0.0077 15.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF3377 PF11857.8 ETO26396.1 - 0.042 13.8 0.0 0.094 12.7 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3377) MMR_HSR1 PF01926.23 ETO26396.1 - 0.14 12.3 0.0 1.5 9.0 0.0 2.2 2 0 0 2 2 2 0 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO26396.1 - 0.15 11.6 0.0 0.2 11.2 0.0 1.3 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain TPR_10 PF13374.6 ETO26397.1 - 2.1e-22 78.3 0.3 3.2e-07 30.0 0.0 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26397.1 - 4.5e-21 74.9 3.6 1.6e-11 44.3 0.1 2.9 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26397.1 - 2.8e-12 45.9 17.7 3.3e-06 26.7 0.1 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26397.1 - 7.1e-12 44.5 12.6 0.00068 19.6 2.6 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26397.1 - 5.7e-08 32.3 1.3 0.06 13.4 0.2 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26397.1 - 3.2e-07 30.0 12.9 0.1 12.9 2.2 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat zf-TRAF PF02176.18 ETO26397.1 - 2.3e-05 25.0 3.5 2.7e-05 24.7 1.5 2.3 2 0 0 2 2 1 1 TRAF-type zinc finger TPR_16 PF13432.6 ETO26397.1 - 8.7e-05 23.1 0.1 0.67 10.6 0.2 2.6 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26397.1 - 0.0011 18.6 11.2 0.0089 15.7 2.0 3.1 4 0 0 4 4 2 2 TPR repeat TPR_17 PF13431.6 ETO26397.1 - 0.0072 16.6 2.7 3 8.4 0.0 3.3 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26397.1 - 0.017 15.9 0.0 12 7.0 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat LMBR1 PF04791.16 ETO26397.1 - 0.032 13.2 9.1 0.05 12.5 9.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein TPR_6 PF13174.6 ETO26397.1 - 0.046 14.4 3.0 10 7.0 0.1 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Exonuc_VII_L PF02601.15 ETO26397.1 - 0.047 13.3 7.6 0.091 12.3 7.6 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit SHNi-TPR PF10516.9 ETO26397.1 - 0.061 12.8 0.3 2.4 7.7 0.0 2.8 3 0 0 3 3 2 0 SHNi-TPR YfiO PF13525.6 ETO26397.1 - 0.13 12.0 0.2 0.13 12.0 0.2 1.9 2 0 0 2 2 2 0 Outer membrane lipoprotein DUF4407 PF14362.6 ETO26397.1 - 0.14 11.5 11.2 0.22 10.8 11.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PPR PF01535.20 ETO26397.1 - 0.18 12.1 0.8 3.6 8.0 0.0 3.4 4 0 0 4 4 3 0 PPR repeat Golgin_A5 PF09787.9 ETO26397.1 - 0.69 9.3 21.4 1.3 8.4 21.4 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 Geminin PF07412.12 ETO26397.1 - 0.76 9.5 16.5 2.4 7.8 5.7 2.4 2 0 0 2 2 2 0 Geminin Cep57_MT_bd PF06657.13 ETO26397.1 - 1.1 9.8 17.0 2.6 8.5 0.6 2.8 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Bacillus_HBL PF05791.11 ETO26397.1 - 2.8 7.7 15.6 2.4 8.0 5.4 2.6 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Atg14 PF10186.9 ETO26397.1 - 4 6.4 22.7 11 5.0 22.8 1.6 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 HIP1_clath_bdg PF16515.5 ETO26397.1 - 4.4 8.0 23.4 10 6.8 15.7 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 WD40 PF00400.32 ETO26398.1 - 6e-63 207.3 20.8 6.8e-11 42.6 0.1 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26398.1 - 9.3e-24 83.6 1.6 0.00087 19.6 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO26398.1 - 1.3e-12 48.0 0.1 0.00028 20.8 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO26398.1 - 2.1e-11 43.4 0.2 0.027 13.4 0.0 5.6 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO26398.1 - 2.9e-09 36.7 2.8 0.0013 18.2 0.1 3.5 2 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO26398.1 - 5.6e-09 35.0 0.6 7.3e-05 21.5 0.0 2.7 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO26398.1 - 1.5e-08 33.7 6.6 0.061 12.0 0.0 5.6 1 1 5 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO26398.1 - 2.8e-05 23.9 4.8 4.2 7.4 0.1 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO26398.1 - 8.1e-05 22.7 2.9 5.6 7.1 0.1 4.8 2 1 3 5 5 5 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO26398.1 - 0.0032 16.8 0.5 0.12 11.7 0.1 3.1 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO26398.1 - 0.0066 15.5 1.3 0.39 9.7 0.1 2.7 1 1 2 3 3 3 1 Coatomer WD associated region PQQ PF01011.21 ETO26398.1 - 0.0079 16.1 0.0 1.1e+02 3.0 0.0 4.8 5 0 0 5 5 5 0 PQQ enzyme repeat NHL PF01436.21 ETO26398.1 - 0.017 15.1 0.1 2.3 8.4 0.1 3.6 4 0 0 4 4 4 0 NHL repeat DUF1797 PF08796.10 ETO26398.1 - 0.026 14.6 0.0 1.3 9.2 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1797) VID27 PF08553.10 ETO26398.1 - 0.039 13.0 0.1 0.22 10.5 0.0 2.2 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain DUF2963 PF11178.8 ETO26398.1 - 0.065 13.0 1.0 1.9 8.2 0.4 3.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2963) Nucleoporin_N PF08801.11 ETO26398.1 - 0.097 11.4 9.9 0.72 8.5 0.7 3.9 1 1 3 4 4 4 0 Nup133 N terminal like DUF3475 PF11961.8 ETO26398.1 - 0.12 12.5 0.5 6.5 6.9 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF3475) Proteasome_A_N PF10584.9 ETO26398.1 - 1.9 8.2 6.0 11 5.8 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO26399.1 - 1.6e-58 193.3 16.9 8.6e-10 39.1 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26399.1 - 1.2e-20 73.6 5.9 8e-06 26.1 0.1 6.3 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO26399.1 - 1.3e-12 47.7 9.5 3.2e-05 23.4 0.2 4.2 3 1 2 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 ETO26399.1 - 1.3e-11 44.1 0.6 0.044 12.7 0.0 5.4 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO26399.1 - 3.3e-10 39.3 5.3 0.22 10.1 0.0 5.8 1 1 5 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO26399.1 - 8.8e-08 31.1 0.8 0.00022 19.9 0.1 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain HPS6 PF15702.5 ETO26399.1 - 0.00023 19.4 0.0 0.071 11.1 0.0 2.4 2 1 1 3 3 3 2 Hermansky-Pudlak syndrome 6 protein Coatomer_WDAD PF04053.14 ETO26399.1 - 0.00077 18.6 7.5 0.6 9.1 0.1 3.2 1 1 1 2 2 2 2 Coatomer WD associated region PALB2_WD40 PF16756.5 ETO26399.1 - 0.0013 17.7 6.6 0.27 10.1 0.0 4.4 1 1 4 5 5 5 2 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 ETO26399.1 - 0.0024 16.7 16.3 0.84 8.3 0.7 5.5 1 1 5 6 6 6 3 Nup133 N terminal like PQQ PF01011.21 ETO26399.1 - 0.0038 17.1 0.0 7.5 6.7 0.0 3.6 3 0 0 3 3 3 1 PQQ enzyme repeat Me-amine-dh_H PF06433.11 ETO26399.1 - 0.0041 16.0 0.2 5.4 5.8 0.0 3.0 2 1 0 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 ETO26399.1 - 0.0075 15.9 0.3 0.067 12.8 0.3 2.4 2 1 0 2 2 2 1 PQQ-like domain SBD PF17882.1 ETO26399.1 - 0.034 14.0 0.8 82 3.0 0.0 4.3 1 1 3 5 5 5 0 OAA-family lectin sugar binding domain RRM_3 PF08777.11 ETO26399.1 - 0.091 12.8 0.2 0.46 10.5 0.1 2.2 1 1 1 2 2 2 0 RNA binding motif PD40 PF07676.12 ETO26399.1 - 0.96 9.5 8.7 11 6.1 0.0 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Striatin PF08232.12 ETO26400.1 - 0.18 12.4 4.5 0.36 11.4 4.5 1.5 1 1 0 1 1 1 0 Striatin family Ras PF00071.22 ETO26402.1 - 1.6e-06 27.8 0.1 0.042 13.5 0.1 2.4 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO26402.1 - 0.0014 18.8 0.2 0.033 14.4 0.0 2.7 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SirB PF04247.12 ETO26405.1 - 0.015 15.4 23.2 0.071 13.2 7.8 2.5 2 1 0 2 2 2 0 Invasion gene expression up-regulator, SirB ADP_ribosyl_GH PF03747.14 ETO26406.1 - 3.7e-17 63.0 0.0 5.9e-17 62.3 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Pyrid_ox_like PF16242.5 ETO26406.1 - 0.058 13.0 0.0 0.12 12.0 0.0 1.4 1 0 0 1 1 1 0 Pyridoxamine 5'-phosphate oxidase like NMD3 PF04981.13 ETO26407.1 - 1.5e-30 106.5 0.6 1.7e-30 106.2 0.6 1.1 1 0 0 1 1 1 1 NMD3 family zf-C3HC4_4 PF15227.6 ETO26407.1 - 0.033 14.4 3.8 1.2 9.4 0.1 3.3 3 0 0 3 3 3 0 zinc finger of C3HC4-type, RING HypA PF01155.19 ETO26407.1 - 0.39 10.7 3.8 2.2 8.3 0.2 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DZR PF12773.7 ETO26407.1 - 0.45 10.6 6.5 3 7.9 6.6 2.0 1 1 1 2 2 2 0 Double zinc ribbon eIF-5_eIF-2B PF01873.17 ETO26407.1 - 0.46 10.4 4.0 4.4 7.2 1.4 2.5 3 0 0 3 3 3 0 Domain found in IF2B/IF5 LRRC37AB_C PF14914.6 ETO26408.1 - 2.4 8.0 4.7 0.5 10.3 0.3 1.9 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain HECT PF00632.25 ETO26409.1 - 1.7e-70 238.0 0.1 2.6e-70 237.3 0.1 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) SPRY PF00622.28 ETO26409.1 - 2.6e-06 27.6 1.2 7.1e-06 26.1 1.2 1.7 1 0 0 1 1 1 1 SPRY domain Fapy_DNA_glyco PF01149.24 ETO26410.1 - 8.1e-30 103.8 0.0 1.1e-29 103.3 0.0 1.2 1 0 0 1 1 1 1 Formamidopyrimidine-DNA glycosylase N-terminal domain H2TH PF06831.14 ETO26410.1 - 4.7e-14 52.1 0.2 2.8e-13 49.7 0.0 2.3 3 0 0 3 3 3 1 Formamidopyrimidine-DNA glycosylase H2TH domain FbpA PF05833.11 ETO26410.1 - 0.089 11.5 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Fibronectin-binding protein A N-terminus (FbpA) Ribosomal_S13 PF00416.22 ETO26410.1 - 0.095 13.1 0.0 0.44 10.9 0.0 1.9 2 0 0 2 2 2 0 Ribosomal protein S13/S18 Adaptin_N PF01602.20 ETO26411.1 - 1.7e-24 86.3 0.3 2.5e-24 85.7 0.3 1.2 1 0 0 1 1 1 1 Adaptin N terminal region Adaptin_N PF01602.20 ETO26412.1 - 2.6e-21 75.8 0.1 3.2e-21 75.5 0.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region CDC45 PF02724.14 ETO26412.1 - 1 7.6 5.3 1.2 7.3 5.3 1.2 1 0 0 1 1 1 0 CDC45-like protein TPR_12 PF13424.6 ETO26414.1 - 9.1e-25 86.8 1.8 2.2e-13 50.3 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26414.1 - 6.3e-17 60.9 0.0 0.00028 20.6 0.1 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26414.1 - 1.8e-16 58.9 0.3 2.7e-05 23.9 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26414.1 - 5.2e-11 41.9 14.0 2.1e-06 27.3 2.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26414.1 - 7.8e-10 38.2 13.5 3.1e-05 23.8 0.9 4.1 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26414.1 - 9.3e-09 34.8 13.5 0.00029 20.7 0.7 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26414.1 - 2.7e-05 24.5 2.0 2.6 8.9 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26414.1 - 2.9e-05 24.1 2.0 0.049 14.0 0.6 3.2 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26414.1 - 0.0013 18.4 7.4 1.8 8.3 1.1 4.6 4 1 1 5 5 5 1 TPR repeat MIT PF04212.18 ETO26414.1 - 0.0022 18.0 6.3 7 6.8 0.1 4.0 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO26414.1 - 0.0025 18.5 0.1 5.6 8.1 0.0 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO26414.1 - 0.0054 17.4 0.3 2.3 8.9 0.0 3.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26414.1 - 0.075 13.6 0.6 1.1 9.8 0.0 3.0 3 1 0 3 3 2 0 Tetratricopeptide repeat Ubiq-assoc PF09145.10 ETO26414.1 - 0.88 9.6 3.0 4.3 7.4 0.5 2.6 2 0 0 2 2 2 0 Ubiquitin-associated SAM_1 PF00536.30 ETO26416.1 - 8.4e-09 35.7 0.3 1.1e-07 32.2 0.2 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO26416.1 - 1.7e-05 24.8 0.1 4.1e-05 23.6 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO26416.1 - 0.00043 20.2 1.3 0.0011 18.9 1.3 1.6 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain DUF4079 PF13301.6 ETO26416.1 - 0.2 11.8 0.1 0.42 10.8 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) COX14 PF14880.6 ETO26416.1 - 6.6 6.7 5.8 1.2 9.0 0.4 2.3 2 0 0 2 2 2 0 Cytochrome oxidase c assembly PH_13 PF16652.5 ETO26417.1 - 0.00084 19.2 5.0 0.089 12.6 5.0 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain PH PF00169.29 ETO26417.1 - 0.0011 19.5 0.7 0.0019 18.6 0.7 1.4 1 0 0 1 1 1 1 PH domain AntA PF08346.12 ETO26417.1 - 0.0054 17.3 1.4 0.0072 16.9 0.6 1.7 1 1 0 1 1 1 1 AntA/AntB antirepressor PDU_like PF15953.5 ETO26417.1 - 0.016 15.3 0.0 0.033 14.3 0.0 1.4 1 1 0 1 1 1 0 Putative propanediol utilisation CathepsinC_exc PF08773.11 ETO26417.1 - 0.035 14.4 1.4 0.046 14.0 0.7 1.5 1 1 0 1 1 1 0 Cathepsin C exclusion domain NUDIX_4 PF14815.6 ETO26417.1 - 0.064 13.2 2.4 0.11 12.5 2.2 1.6 1 1 0 1 1 1 0 NUDIX domain Lipase_3 PF01764.25 ETO26417.1 - 0.15 12.0 0.2 4.1 7.3 0.1 2.3 2 0 0 2 2 2 0 Lipase (class 3) PH_16 PF17838.1 ETO26417.1 - 0.15 11.9 1.5 0.46 10.3 1.5 1.8 1 1 0 1 1 1 0 PH domain Kelch_1 PF01344.25 ETO26418.1 - 0.00098 18.7 2.3 0.025 14.2 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Aha1_N PF09229.11 ETO26419.1 - 9e-11 42.1 1.4 9e-11 42.1 1.4 2.7 2 2 0 2 2 2 1 Activator of Hsp90 ATPase, N-terminal SRP-alpha_N PF04086.13 ETO26419.1 - 0.63 9.9 25.2 1 9.2 25.2 1.3 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal MDFI PF15316.6 ETO26419.1 - 0.67 10.0 17.6 0.17 12.0 13.1 1.9 1 1 1 2 2 2 0 MyoD family inhibitor FPL PF09758.9 ETO26420.1 - 3.6e-40 137.4 14.2 2.9e-35 121.5 7.5 2.8 3 0 0 3 3 3 2 Uncharacterised conserved protein DsrC PF04358.13 ETO26422.1 - 0.053 14.0 0.1 0.13 12.8 0.1 1.7 1 0 0 1 1 1 0 DsrC like protein Ank_2 PF12796.7 ETO26423.1 - 2.6e-105 345.2 25.4 1.2e-17 64.2 0.1 8.1 2 2 8 10 10 10 10 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO26423.1 - 2.6e-61 203.3 10.7 3.3e-10 40.3 0.0 10.5 6 2 4 10 10 10 10 Ankyrin repeats (many copies) Ank PF00023.30 ETO26423.1 - 1.2e-50 167.8 14.9 5.5e-06 26.6 0.0 13.5 13 0 0 13 13 13 10 Ankyrin repeat Ank_3 PF13606.6 ETO26423.1 - 2.2e-50 162.7 16.7 0.00059 20.1 0.0 14.4 14 0 0 14 14 14 12 Ankyrin repeat Ank_5 PF13857.6 ETO26423.1 - 4.4e-43 144.8 20.4 3.4e-08 33.6 0.1 11.1 6 4 6 12 12 12 6 Ankyrin repeats (many copies) CAP_GLY PF01302.25 ETO26423.1 - 4.4e-28 97.1 2.1 1.7e-17 63.2 0.3 2.5 2 0 0 2 2 2 2 CAP-Gly domain Imm_superinfect PF14373.6 ETO26423.1 - 0.028 14.3 0.3 1.3e+02 2.7 0.0 5.1 6 0 0 6 6 6 0 Superinfection immunity protein CDC45 PF02724.14 ETO26423.1 - 0.062 11.6 4.3 0.11 10.8 4.3 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF2828 PF11443.8 ETO26424.1 - 0.012 13.8 6.2 0.014 13.5 6.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF2828) Zip PF02535.22 ETO26424.1 - 0.04 13.1 4.7 0.044 13.0 4.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNA_pol_Rpc82 PF05645.13 ETO26424.1 - 0.16 11.7 8.7 0.2 11.4 8.7 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 DUF4519 PF15012.6 ETO26424.1 - 0.48 10.6 19.0 0.41 10.9 2.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) EMC3_TMCO1 PF01956.16 ETO26424.1 - 1.5 8.5 7.6 2.6 7.7 7.2 1.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Sec62 PF03839.16 ETO26424.1 - 2.4 7.6 10.8 2.9 7.3 10.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 DUF3304 PF11745.8 ETO26424.1 - 4.7 7.7 8.0 21 5.5 7.7 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3304) MDFI PF15316.6 ETO26424.1 - 9.8 6.2 10.0 7.2 6.7 8.7 1.4 1 1 0 1 1 1 0 MyoD family inhibitor PPR_2 PF13041.6 ETO26425.1 - 3.9e-12 46.2 4.1 2.6e-05 24.3 0.4 3.2 2 1 1 3 3 3 3 PPR repeat family PPR PF01535.20 ETO26425.1 - 1.2e-09 37.8 6.5 0.04 14.2 0.3 4.7 4 0 0 4 4 4 3 PPR repeat PPR_3 PF13812.6 ETO26425.1 - 6.7e-05 22.9 0.9 0.0041 17.2 0.1 3.3 2 1 1 3 3 3 1 Pentatricopeptide repeat domain ATP13 PF12921.7 ETO26425.1 - 0.0014 18.5 1.3 0.53 10.2 0.1 3.0 2 1 1 3 3 3 2 Mitochondrial ATPase expression PPR_1 PF12854.7 ETO26425.1 - 0.024 14.3 1.4 27 4.6 0.0 3.9 4 0 0 4 4 4 0 PPR repeat Mnd1 PF03962.15 ETO26426.1 - 1.8e-06 28.1 0.0 3.8e-06 27.1 0.0 1.5 1 0 0 1 1 1 1 Mnd1 HTH domain WD40 PF00400.32 ETO26427.1 - 6.1e-65 213.6 9.8 1.4e-11 44.8 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26427.1 - 1.6e-22 79.6 1.8 0.002 18.4 0.0 6.5 3 1 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO26427.1 - 1.3e-15 57.6 0.0 0.00042 19.7 0.0 4.4 3 2 1 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO26427.1 - 5.9e-10 38.4 3.7 0.51 8.9 0.1 5.8 1 1 4 5 5 5 5 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO26427.1 - 7.2e-08 31.3 0.7 0.00031 19.4 0.0 3.3 1 1 1 3 3 3 2 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ETO26427.1 - 1.4e-07 30.8 0.0 3.7 6.4 0.0 5.5 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO26427.1 - 1.2e-05 25.4 0.6 28 4.8 0.0 5.2 3 2 2 5 5 5 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO26427.1 - 3.8e-05 22.6 9.8 2 7.0 0.3 5.5 1 1 5 6 6 6 4 Nup133 N terminal like PD40 PF07676.12 ETO26427.1 - 0.00018 21.3 2.1 7 6.7 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO26427.1 - 0.00037 19.4 0.4 0.13 11.0 0.1 3.2 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_2 PF13360.6 ETO26427.1 - 0.00059 19.5 1.1 0.0029 17.2 0.9 2.4 2 1 0 2 2 2 1 PQQ-like domain PQQ PF01011.21 ETO26427.1 - 0.0023 17.8 0.0 86 3.3 0.0 5.4 6 0 0 6 6 6 0 PQQ enzyme repeat HPS6 PF15702.5 ETO26427.1 - 0.0028 15.8 0.0 1.2 7.1 0.0 3.3 3 1 1 4 4 4 1 Hermansky-Pudlak syndrome 6 protein BBS2_Mid PF14783.6 ETO26427.1 - 0.022 14.8 0.3 32 4.6 0.0 4.3 4 1 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region DUF2963 PF11178.8 ETO26427.1 - 0.12 12.1 5.4 3.8 7.3 0.0 4.1 3 1 0 3 3 2 0 Protein of unknown function (DUF2963) SBD PF17882.1 ETO26427.1 - 0.21 11.4 0.8 25 4.7 0.0 3.7 1 1 1 3 3 3 0 OAA-family lectin sugar binding domain Methyltransf_16 PF10294.9 ETO26429.1 - 2.5e-18 66.4 0.0 3.8e-18 65.8 0.0 1.3 1 0 0 1 1 1 1 Lysine methyltransferase WD40 PF00400.32 ETO26431.1 - 1.3e-24 85.9 10.7 3.9e-09 37.0 0.1 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO26431.1 - 0.0093 14.7 0.9 0.82 8.2 0.0 2.3 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO26431.1 - 0.019 13.7 1.5 0.14 10.9 1.1 2.1 1 1 0 1 1 1 0 Nup133 N terminal like WD40_like PF17005.5 ETO26431.1 - 0.022 14.1 1.1 0.098 12.0 0.2 2.1 2 0 0 2 2 2 0 WD40-like domain Cerato-platanin PF07249.12 ETO26431.1 - 0.065 13.4 1.1 0.092 12.9 0.1 1.7 2 0 0 2 2 2 0 Cerato-platanin Aa_trans PF01490.18 ETO26432.1 - 2.8e-13 49.4 2.9 3.8e-13 48.9 1.5 1.8 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein EI24 PF07264.11 ETO26432.1 - 9.9e-06 25.9 1.4 2.3e-05 24.7 0.0 2.0 2 0 0 2 2 2 1 Etoposide-induced protein 2.4 (EI24) TerC PF03741.16 ETO26432.1 - 0.007 16.1 0.1 0.018 14.7 0.1 1.7 1 0 0 1 1 1 1 Integral membrane protein TerC family Pox_P21 PF05313.12 ETO26432.1 - 0.026 14.1 0.0 0.049 13.2 0.0 1.4 1 0 0 1 1 1 0 Poxvirus P21 membrane protein Wzy_C PF04932.15 ETO26432.1 - 0.12 11.9 0.0 0.12 11.9 0.0 2.7 2 1 0 2 2 2 0 O-Antigen ligase DUF2207 PF09972.9 ETO26432.1 - 0.14 10.9 5.2 2.6 6.7 4.6 2.9 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) AA_permease PF00324.21 ETO26433.1 - 1.1e-19 70.4 14.5 1.4e-19 70.0 14.5 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3438 PF11920.8 ETO26433.1 - 1.6 7.9 4.0 2.6 7.2 4.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) AA_permease PF00324.21 ETO26434.1 - 2.6e-20 72.5 19.8 1.6e-19 69.9 19.8 1.8 1 1 0 1 1 1 1 Amino acid permease GSG-1 PF07803.11 ETO26437.1 - 0.032 14.1 1.8 0.035 14.0 1.8 1.0 1 0 0 1 1 1 0 GSG1-like protein Methyltransf_12 PF08242.12 ETO26437.1 - 0.045 14.5 1.6 0.06 14.1 1.6 1.3 1 0 0 1 1 1 0 Methyltransferase domain POX PF07526.11 ETO26437.1 - 0.12 13.0 3.7 0.13 12.8 3.7 1.1 1 0 0 1 1 1 0 Associated with HOX Apis_Csd PF11671.8 ETO26437.1 - 0.2 11.7 11.1 0.2 11.7 11.1 1.1 1 0 0 1 1 1 0 Complementary sex determiner protein Menin PF05053.13 ETO26437.1 - 1.4 7.2 8.5 1.3 7.3 8.5 1.0 1 0 0 1 1 1 0 Menin MAP17 PF15807.5 ETO26437.1 - 1.7 8.9 9.7 2.3 8.5 9.7 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Pkinase PF00069.25 ETO26438.1 - 1e-58 198.8 0.7 1.1e-49 169.1 0.1 2.5 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26438.1 - 1e-25 90.5 0.2 4.2e-25 88.5 0.2 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase CDC45 PF02724.14 ETO26438.1 - 4.3e-05 22.0 18.8 6.6e-05 21.4 18.8 1.3 1 0 0 1 1 1 1 CDC45-like protein APH PF01636.23 ETO26438.1 - 0.032 14.2 0.0 0.07 13.0 0.0 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family DDHD PF02862.17 ETO26438.1 - 0.21 11.7 11.1 0.53 10.4 11.1 1.7 1 0 0 1 1 1 0 DDHD domain Zip PF02535.22 ETO26438.1 - 2 7.6 12.5 3.7 6.7 12.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter SAPS PF04499.15 ETO26438.1 - 3.4 6.3 16.6 5.2 5.7 16.6 1.2 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein G-alpha PF00503.20 ETO26439.1 - 6.8e-45 153.8 6.4 8e-45 153.5 6.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO26439.1 - 1.5e-08 34.3 0.6 3.5e-08 33.1 0.6 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO26439.1 - 6.3e-06 25.7 2.2 8.6e-06 25.3 2.2 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO26439.1 - 0.028 13.9 0.1 0.034 13.7 0.1 1.5 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain DUF3915 PF13054.6 ETO26439.1 - 0.1 12.6 0.1 0.16 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Sep15_SelM PF08806.11 ETO26440.1 - 1.8e-24 85.7 0.3 4.5e-24 84.4 0.0 1.7 2 0 0 2 2 2 1 Sep15/SelM redox domain MIT_C PF16565.5 ETO26440.1 - 0.04 13.9 0.2 0.06 13.3 0.2 1.3 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT Hrs_helical PF12210.8 ETO26441.1 - 0.087 13.4 0.2 0.14 12.7 0.2 1.4 1 0 0 1 1 1 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Pox_A14 PF05767.12 ETO26442.1 - 0.008 16.3 0.3 0.31 11.2 0.1 2.5 2 0 0 2 2 2 2 Poxvirus virion envelope protein A14 EcoR124_C PF12008.8 ETO26444.1 - 0.023 14.4 1.4 0.1 12.2 0.1 2.3 2 0 0 2 2 2 0 Type I restriction and modification enzyme - subunit R C terminal UPF0139 PF03669.13 ETO26444.1 - 0.072 13.0 0.4 0.39 10.6 0.2 2.3 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) YqfQ PF14181.6 ETO26445.1 - 6.8 6.9 9.6 2.3 8.4 6.7 1.7 2 0 0 2 2 2 0 YqfQ-like protein Peptidase_S49_N PF08496.10 ETO26445.1 - 8.3 6.4 9.1 1e+02 2.9 0.0 2.5 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4287 PF14117.6 ETO26446.1 - 0.019 15.1 0.3 0.036 14.2 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4287) LAP1C PF05609.12 ETO26446.1 - 0.022 13.9 18.2 0.029 13.5 18.2 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nop14 PF04147.12 ETO26446.1 - 0.076 11.2 32.4 0.092 11.0 32.4 1.1 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 ETO26446.1 - 1.1 6.9 16.3 1.5 6.6 16.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit SDA1 PF05285.12 ETO26446.1 - 2 7.7 35.9 2.9 7.3 35.9 1.3 1 0 0 1 1 1 0 SDA1 Peptidase_S64 PF08192.11 ETO26446.1 - 3.4 6.1 13.4 4 5.8 13.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 DNA_pol_phi PF04931.13 ETO26446.1 - 5.1 5.1 33.9 8.8 4.3 33.9 1.4 1 0 0 1 1 1 0 DNA polymerase phi BUD22 PF09073.10 ETO26446.1 - 6 6.1 33.8 8 5.7 33.8 1.1 1 0 0 1 1 1 0 BUD22 PH PF00169.29 ETO26447.1 - 1.1e-09 38.7 0.1 4.8e-09 36.7 0.1 2.1 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO26447.1 - 9.4e-09 35.3 0.1 3.8e-08 33.4 0.0 1.9 2 0 0 2 2 2 1 PH domain Vps62 PF06101.11 ETO26447.1 - 2e-06 26.4 0.0 3.1e-06 25.8 0.0 1.2 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 62 Myosin_TH1 PF06017.13 ETO26447.1 - 0.00028 20.6 0.0 0.00078 19.2 0.0 1.8 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Polysacc_synt PF01943.17 ETO26447.1 - 0.055 12.8 7.7 0.1 12.0 7.7 1.3 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein PAN_4 PF14295.6 ETO26448.1 - 0.047 13.6 0.2 0.14 12.1 0.2 1.8 1 0 0 1 1 1 0 PAN domain HECT PF00632.25 ETO26449.1 - 5e-89 298.8 0.5 5e-89 298.8 0.5 2.0 3 0 0 3 3 3 1 HECT-domain (ubiquitin-transferase) BUD22 PF09073.10 ETO26449.1 - 0.0099 15.3 29.6 0.041 13.2 16.4 2.2 2 0 0 2 2 2 2 BUD22 Trypan_PARP PF05887.11 ETO26449.1 - 0.028 14.4 26.7 0.24 11.4 9.1 2.4 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) SDA1 PF05285.12 ETO26449.1 - 0.034 13.6 28.9 0.17 11.3 3.6 2.2 2 0 0 2 2 2 0 SDA1 Zip PF02535.22 ETO26449.1 - 0.13 11.4 7.0 0.51 9.5 1.1 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter CDC45 PF02724.14 ETO26449.1 - 0.3 9.3 20.2 0.79 7.9 10.5 2.2 2 0 0 2 2 2 0 CDC45-like protein DUF4228 PF14009.6 ETO26449.1 - 1.6 9.1 6.0 6.1 7.2 1.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) CPSF100_C PF13299.6 ETO26449.1 - 1.7 8.8 19.4 3.4 7.8 3.9 2.7 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 ETO26449.1 - 1.9 7.5 11.2 4.7 6.1 1.8 2.4 2 0 0 2 2 2 0 CLN3 protein Vfa1 PF08432.10 ETO26449.1 - 2.7 8.3 37.5 0.29 11.5 14.4 3.1 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 ETO26449.1 - 4 6.3 13.4 3.5 6.5 3.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO26449.1 - 5.4 5.7 23.1 3.7 6.2 11.2 2.4 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ETO26449.1 - 5.8 6.6 19.4 1.1 8.9 1.0 2.6 2 1 1 3 3 3 0 Connexin DUF3464 PF11947.8 ETO26449.1 - 9.3 6.0 19.0 0.17 11.7 1.3 2.6 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TPK_catalytic PF04263.16 ETO26452.1 - 2e-23 82.7 0.0 3.2e-23 82.1 0.0 1.3 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain TPK_B1_binding PF04265.14 ETO26452.1 - 2.2e-16 59.3 0.1 4.5e-16 58.3 0.1 1.5 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, vitamin B1 binding domain Transferase PF02458.15 ETO26454.1 - 0.029 13.0 0.0 0.047 12.3 0.0 1.3 1 1 0 1 1 1 0 Transferase family FAM176 PF14851.6 ETO26455.1 - 1.4 8.5 10.1 1.7 8.3 10.1 1.3 1 0 0 1 1 1 0 FAM176 family BSP_II PF05432.11 ETO26455.1 - 3.7 7.2 17.7 3.6 7.2 17.7 1.0 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Radial_spoke PF04712.12 ETO26455.1 - 7.2 5.4 14.5 7.6 5.4 14.5 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Mpp10 PF04006.12 ETO26455.1 - 7.3 4.9 14.9 7.2 4.9 14.9 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF4637 PF15470.6 ETO26455.1 - 7.5 6.3 13.1 7.3 6.3 13.1 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Nop14 PF04147.12 ETO26455.1 - 8.5 4.5 17.7 7.7 4.6 17.7 1.0 1 0 0 1 1 1 0 Nop14-like family Rhodanese PF00581.20 ETO26456.1 - 0.00079 19.9 0.0 0.0021 18.6 0.0 1.8 1 0 0 1 1 1 1 Rhodanese-like domain CNDH2_C PF16858.5 ETO26456.1 - 0.35 10.7 8.6 0.59 10.0 8.6 1.3 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term ParB PF08775.10 ETO26457.1 - 2.3 8.7 10.8 0.82 10.2 1.9 2.6 2 1 0 2 2 2 0 ParB family Patatin PF01734.22 ETO26460.1 - 1.6e-05 25.2 0.0 1.8e-05 25.0 0.0 1.1 1 0 0 1 1 1 1 Patatin-like phospholipase zf_CCCH_4 PF18345.1 ETO26463.1 - 0.0081 16.2 1.3 0.0081 16.2 1.3 2.7 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 ETO26463.1 - 0.017 14.9 0.1 0.017 14.9 0.1 2.8 3 0 0 3 3 3 0 CCCH-type zinc finger Zip PF02535.22 ETO26463.1 - 0.37 9.9 7.4 0.59 9.3 7.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Met_gamma_lyase PF06838.11 ETO26465.1 - 0.018 13.6 0.3 0.028 13.0 0.3 1.3 1 0 0 1 1 1 0 Methionine gamma-lyase LepA_C PF06421.12 ETO26465.1 - 0.6 10.3 5.3 11 6.2 0.0 3.1 3 0 0 3 3 3 0 GTP-binding protein LepA C-terminus DMPK_coil PF08826.10 ETO26465.1 - 2.7 8.2 7.3 12 6.1 4.7 2.4 2 0 0 2 2 2 0 DMPK coiled coil domain like DUF3357 PF11837.8 ETO26466.1 - 0.0019 18.6 0.2 0.18 12.3 0.0 2.4 1 1 1 2 2 2 2 Domain of unknown function (DUF3357) DUF4271 PF14093.6 ETO26466.1 - 0.041 13.8 2.2 0.062 13.2 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4271) EpsG PF14897.6 ETO26466.1 - 0.24 10.7 7.1 0.023 14.0 1.3 1.8 2 0 0 2 2 2 0 EpsG family PIN_6 PF17146.4 ETO26468.1 - 4.1 8.0 5.8 4.4 7.9 0.1 3.7 3 1 0 3 3 3 0 PIN domain of ribonuclease MRP-L51 PF10244.9 ETO26468.1 - 9.7 6.5 12.1 1.1 9.6 0.8 4.1 4 1 1 5 5 5 0 Mitochondrial ribosomal subunit WD40 PF00400.32 ETO26469.1 - 1.6e-11 44.5 3.0 0.26 12.2 0.0 7.1 7 0 0 7 7 7 4 WD domain, G-beta repeat DUF4969 PF16339.5 ETO26469.1 - 0.078 13.3 0.0 0.3 11.4 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4969) FeoB_associated PF12669.7 ETO26469.1 - 0.16 12.4 3.1 8.4 6.9 0.1 2.8 2 0 0 2 2 2 0 FeoB-associated Cys-rich membrane protein OppC_N PF12911.7 ETO26469.1 - 0.33 11.0 2.9 25 4.9 0.0 2.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C MAP17 PF15807.5 ETO26469.1 - 1.8 8.8 0.0 1.8 8.8 0.0 3.1 3 1 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 RasGEF PF00617.19 ETO26470.1 - 0.00015 22.0 0.0 0.00027 21.2 0.0 1.4 2 0 0 2 2 2 1 RasGEF domain Sigma70_ECF PF07638.11 ETO26470.1 - 0.0086 16.0 0.0 0.0093 15.9 0.0 1.1 1 0 0 1 1 1 1 ECF sigma factor RasGEF PF00617.19 ETO26471.1 - 1.1e-19 71.3 1.4 1.5e-19 70.8 0.2 1.9 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ETO26471.1 - 3e-13 49.9 0.5 8.6e-13 48.4 0.2 1.9 2 0 0 2 2 2 1 RasGEF N-terminal motif DUF846 PF05832.12 ETO26471.1 - 0.2 11.7 0.2 0.36 10.9 0.2 1.4 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF846) Cytomega_UL84 PF06284.11 ETO26471.1 - 0.34 9.3 2.0 0.59 8.5 2.0 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein RP-C_C PF11800.8 ETO26471.1 - 0.56 10.3 6.3 4.8 7.2 1.4 2.4 2 0 0 2 2 2 0 Replication protein C C-terminal region DAG_kinase_N PF14513.6 ETO26471.1 - 0.73 10.0 5.8 3.2 7.9 2.5 2.7 3 0 0 3 3 3 0 Diacylglycerol kinase N-terminus DUF3915 PF13054.6 ETO26471.1 - 7.7 6.5 7.2 0.94 9.5 0.8 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3915) Dsh_C PF12316.8 ETO26471.1 - 8.5 6.7 10.6 2.3 8.6 3.5 2.2 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Peptidase_M2 PF01401.18 ETO26472.1 - 0.0038 15.9 0.6 0.0051 15.5 0.6 1.1 1 0 0 1 1 1 1 Angiotensin-converting enzyme tRNA_NucTransf2 PF09249.11 ETO26472.1 - 0.06 13.6 0.1 0.18 12.1 0.1 1.7 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain CENP-H PF05837.12 ETO26472.1 - 0.078 13.4 3.2 0.16 12.4 3.2 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) PilJ PF13675.6 ETO26472.1 - 0.13 12.3 1.9 0.24 11.5 1.9 1.4 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term ZapB PF06005.12 ETO26472.1 - 0.34 11.4 9.5 0.92 10.0 1.0 2.4 2 0 0 2 2 2 0 Cell division protein ZapB DUF4404 PF14357.6 ETO26472.1 - 3.8 8.2 11.1 0.19 12.4 2.3 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Prefoldin PF02996.17 ETO26472.1 - 7.2 6.6 9.5 4.3 7.3 1.6 2.4 2 0 0 2 2 2 0 Prefoldin subunit VWA_2 PF13519.6 ETO26473.1 - 7.4e-06 26.6 0.0 1.6e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO26473.1 - 0.00028 21.2 0.0 0.0017 18.6 0.0 2.2 1 1 0 1 1 1 1 von Willebrand factor type A domain Helicase_C PF00271.31 ETO26473.1 - 0.093 13.1 0.1 0.44 10.9 0.1 2.3 1 1 0 1 1 1 0 Helicase conserved C-terminal domain VWA_2 PF13519.6 ETO26474.1 - 0.0011 19.5 0.0 0.96 10.1 0.0 3.1 1 1 1 2 2 2 2 von Willebrand factor type A domain EMP24_GP25L PF01105.24 ETO26474.1 - 0.1 12.5 9.2 0.28 11.1 2.7 2.9 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD zf-Sec23_Sec24 PF04810.15 ETO26475.1 - 7.8e-05 22.6 2.5 0.00056 19.9 0.3 2.3 2 0 0 2 2 2 2 Sec23/Sec24 zinc finger Ank_3 PF13606.6 ETO26476.1 - 8.6e-07 28.8 0.1 0.17 12.5 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 ETO26476.1 - 5.6e-06 26.9 0.0 0.035 14.7 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO26476.1 - 1.3e-05 25.6 0.1 0.016 15.8 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO26476.1 - 2.5e-05 24.5 0.3 0.34 11.3 0.0 2.6 2 1 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO26476.1 - 0.0004 20.7 0.2 0.42 11.2 0.0 2.7 3 0 0 3 3 3 2 Ankyrin repeat HEAT_2 PF13646.6 ETO26477.1 - 0.0019 18.5 0.0 3.3 8.2 0.0 4.1 2 2 2 4 4 4 2 HEAT repeats Ank_3 PF13606.6 ETO26477.1 - 0.007 16.8 0.1 0.068 13.7 0.0 2.9 3 0 0 3 3 3 1 Ankyrin repeat TAN PF11640.8 ETO26477.1 - 0.041 14.0 5.5 5.6 7.1 1.2 3.8 1 1 2 3 3 3 0 Telomere-length maintenance and DNA damage repair HEAT PF02985.22 ETO26477.1 - 0.065 13.5 1.5 66 4.2 0.0 4.8 5 0 0 5 5 5 0 HEAT repeat HEAT PF02985.22 ETO26478.1 - 5.8e-05 23.0 0.1 0.16 12.3 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat HEAT_EZ PF13513.6 ETO26478.1 - 0.039 14.5 0.0 0.78 10.3 0.0 2.6 2 0 0 2 2 2 0 HEAT-like repeat HEAT_2 PF13646.6 ETO26478.1 - 0.04 14.3 0.0 0.28 11.6 0.0 2.3 2 1 0 2 2 2 0 HEAT repeats PhnA_Zn_Ribbon PF08274.12 ETO26478.1 - 0.15 12.0 0.3 0.4 10.7 0.3 1.6 1 0 0 1 1 1 0 PhnA Zinc-Ribbon Vac14_Fab1_bd PF12755.7 ETO26478.1 - 0.21 12.2 5.1 0.19 12.3 0.4 3.0 1 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region MyTH4 PF00784.17 ETO26478.1 - 9.1 6.8 8.8 1.6 9.3 0.7 3.3 2 2 0 2 2 2 0 MyTH4 domain Tat PF00539.18 ETO26479.1 - 0.15 12.2 0.4 0.29 11.3 0.4 1.4 1 0 0 1 1 1 0 Transactivating regulatory protein (Tat) TFIIA PF03153.13 ETO26480.1 - 0.26 11.2 16.1 0.48 10.4 16.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Arm PF00514.23 ETO26481.1 - 1.5e-06 28.0 14.8 0.0031 17.5 0.6 7.2 7 1 0 7 7 7 2 Armadillo/beta-catenin-like repeat PH PF00169.29 ETO26481.1 - 0.0001 22.8 1.4 0.00081 19.9 0.0 2.5 2 0 0 2 2 2 1 PH domain Arm_2 PF04826.13 ETO26481.1 - 0.00041 19.9 6.7 0.23 10.9 1.7 3.8 3 1 0 3 3 3 2 Armadillo-like Atx10homo_assoc PF09759.9 ETO26481.1 - 0.0019 18.2 13.0 0.045 13.8 1.2 5.0 4 1 1 5 5 5 1 Spinocerebellar ataxia type 10 protein domain GntP_permease PF02447.16 ETO26481.1 - 0.029 13.1 0.0 0.054 12.2 0.0 1.4 1 0 0 1 1 1 0 GntP family permease NopRA1 PF16201.5 ETO26481.1 - 0.03 13.9 0.4 1.5 8.3 0.0 3.3 3 0 0 3 3 3 0 Nucleolar pre-ribosomal-associated protein 1 RTP1_C1 PF10363.9 ETO26481.1 - 0.036 14.2 0.1 0.32 11.2 0.0 2.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 Mcp5_PH PF12814.7 ETO26481.1 - 0.042 14.0 0.0 0.086 13.0 0.0 1.5 1 0 0 1 1 1 0 Meiotic cell cortex C-terminal pleckstrin homology RICTOR_V PF14668.6 ETO26481.1 - 0.097 12.9 0.5 27 5.1 0.0 3.9 4 0 0 4 4 4 0 Rapamycin-insensitive companion of mTOR, domain 5 HEAT PF02985.22 ETO26481.1 - 1 9.8 6.3 2.2 8.8 0.4 4.4 4 0 0 4 4 4 0 HEAT repeat TAFII55_N PF04658.13 ETO26483.1 - 0.024 14.3 0.0 0.029 14.1 0.0 1.2 1 0 0 1 1 1 0 TAFII55 protein conserved region Amb_V_allergen PF03913.13 ETO26483.1 - 0.034 14.1 0.1 0.034 14.1 0.1 1.9 2 0 0 2 2 2 0 Amb V Allergen CARD_2 PF16739.5 ETO26483.1 - 0.048 13.7 0.0 0.33 11.0 0.0 2.1 2 0 0 2 2 2 0 Caspase recruitment domain Cyclin PF08613.11 ETO26484.1 - 0.00043 20.7 1.3 0.00069 20.0 0.4 1.7 1 1 1 2 2 2 1 Cyclin Spuma_A9PTase PF03539.14 ETO26484.1 - 0.091 12.9 0.2 0.091 12.9 0.2 1.8 2 0 0 2 2 2 0 Spumavirus aspartic protease (A9) DUF4083 PF13314.6 ETO26484.1 - 0.16 11.9 0.1 0.16 11.9 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4083) RRM_1 PF00076.22 ETO26485.1 - 7.4e-11 41.7 0.2 5.3e-10 39.0 0.1 2.2 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO26485.1 - 0.045 13.8 0.1 0.076 13.1 0.1 1.6 1 1 0 1 1 1 0 RNA binding motif GAPES1 PF17155.4 ETO26485.1 - 0.058 12.7 0.5 0.083 12.2 0.3 1.2 1 1 0 1 1 1 0 Gammaproteobacterial periplasmic sensor domain DUF4042 PF13251.6 ETO26487.1 - 4.5e-10 39.5 0.1 1.9e-06 27.7 0.0 2.6 1 1 0 2 2 2 2 Domain of unknown function (DUF4042) 7TMR-HDED PF07697.11 ETO26487.1 - 0.057 13.5 0.0 0.45 10.6 0.0 2.1 2 0 0 2 2 2 0 7TM-HD extracellular Ipi1_N PF12333.8 ETO26487.1 - 0.075 13.6 0.2 5.8 7.6 0.0 3.1 3 0 0 3 3 3 0 Rix1 complex component involved in 60S ribosome maturation HEAT PF02985.22 ETO26487.1 - 0.088 13.1 0.2 1.7 9.1 0.0 2.8 2 0 0 2 2 2 0 HEAT repeat EPSP_synthase PF00275.20 ETO26489.1 - 0.024 13.4 0.3 0.044 12.5 0.0 1.5 2 0 0 2 2 2 0 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase) DUF4834 PF16118.5 ETO26489.1 - 0.033 15.1 6.3 0.033 15.1 6.3 6.3 2 1 3 5 5 5 0 Domain of unknown function (DUF4834) BTB PF00651.31 ETO26490.1 - 7e-22 77.8 4.3 3.8e-13 49.6 1.6 4.1 3 1 0 3 3 3 2 BTB/POZ domain BTB_3 PF16017.5 ETO26490.1 - 0.038 14.1 0.2 3.6 7.8 0.0 2.9 2 1 1 3 3 3 0 BTB/POZ domain Pox_Ag35 PF03286.14 ETO26490.1 - 1.3 8.8 8.9 2.2 8.0 8.9 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 ETO26490.1 - 8.3 6.9 10.5 17 5.8 10.5 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2457 PF10446.9 ETO26490.1 - 8.6 5.4 13.3 12 4.9 13.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) TMEM154 PF15102.6 ETO26491.1 - 0.0015 18.5 3.3 0.0018 18.2 1.0 2.3 2 0 0 2 2 2 1 TMEM154 protein family Shisa PF13908.6 ETO26491.1 - 0.041 14.1 0.2 0.12 12.6 0.2 1.8 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator zf-LITAF-like PF10601.9 ETO26491.1 - 0.047 14.0 0.1 0.085 13.1 0.1 1.3 1 0 0 1 1 1 0 LITAF-like zinc ribbon domain COX2_TM PF02790.15 ETO26491.1 - 0.077 13.1 0.0 1.6 9.0 0.1 2.2 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF1634 PF07843.11 ETO26491.1 - 0.081 13.0 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1634) EphA2_TM PF14575.6 ETO26491.1 - 0.11 13.4 0.0 0.4 11.6 0.0 1.9 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain OAD_gamma PF04277.13 ETO26491.1 - 3 8.5 4.6 11 6.7 0.0 3.3 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain BRCT PF00533.26 ETO26492.1 - 7.6e-05 23.0 0.6 0.00047 20.5 0.4 2.4 3 0 0 3 3 2 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ETO26492.1 - 0.0094 16.3 3.1 0.047 14.1 0.1 2.7 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ETO26492.1 - 0.025 14.4 0.2 0.025 14.4 0.2 2.3 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain PTCB-BRCT PF12738.7 ETO26492.1 - 0.12 12.3 0.1 1.2 9.2 0.1 2.6 3 0 0 3 3 3 0 twin BRCT domain Radial_spoke PF04712.12 ETO26492.1 - 0.18 10.7 9.4 0.3 10.0 9.4 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein PTPRCAP PF15713.5 ETO26492.1 - 0.61 10.4 11.0 1.3 9.3 11.0 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 ETO26492.1 - 0.61 8.3 10.7 0.86 7.8 10.7 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4746 PF15928.5 ETO26492.1 - 3.7 6.9 11.6 6.2 6.1 11.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Trypan_PARP PF05887.11 ETO26492.1 - 4.2 7.4 8.1 7.4 6.6 8.1 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Pneumo_phosprot PF02478.16 ETO26492.1 - 5.3 6.5 14.1 9.1 5.7 14.1 1.3 1 0 0 1 1 1 0 Pneumovirus phosphoprotein DUF1980 PF09323.10 ETO26492.1 - 6.2 6.7 7.5 14 5.5 7.5 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PAXIP1_C PF15364.6 ETO26492.1 - 6.3 7.1 16.1 0.59 10.4 11.1 1.9 2 1 0 2 2 2 0 PAXIP1-associated-protein-1 C term PTIP binding protein TFB6 PF17110.5 ETO26492.1 - 9.8 5.9 8.2 23 4.7 8.2 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PT PF04886.12 ETO26493.1 - 1.2e-08 34.3 47.5 0.00023 20.6 20.5 3.0 1 1 1 2 2 2 2 PT repeat Sporozoite_P67 PF05642.11 ETO26495.1 - 0.059 11.5 1.6 0.055 11.6 1.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NAC PF01849.18 ETO26497.1 - 8.7e-14 51.2 2.2 4.8e-06 26.4 0.0 2.4 2 0 0 2 2 2 2 NAC domain LAP1C PF05609.12 ETO26497.1 - 0.004 16.3 5.8 0.0052 15.9 5.8 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) Ndc1_Nup PF09531.10 ETO26497.1 - 0.039 12.7 5.7 0.053 12.2 5.7 1.4 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup XK-related PF09815.9 ETO26497.1 - 0.11 11.5 1.3 0.34 9.9 0.0 1.9 2 0 0 2 2 2 0 XK-related protein SPX PF03105.19 ETO26497.1 - 0.27 11.1 13.1 0.25 11.2 11.6 1.6 2 0 0 2 2 2 0 SPX domain Ribosomal_L30 PF00327.20 ETO26497.1 - 1.2 9.0 6.6 0.34 10.8 1.6 2.5 3 0 0 3 3 3 0 Ribosomal protein L30p/L7e SOG2 PF10428.9 ETO26497.1 - 5.3 6.1 15.7 7.5 5.6 15.7 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein UBA_4 PF14555.6 ETO26498.1 - 0.079 12.8 0.0 0.18 11.7 0.0 1.5 1 0 0 1 1 1 0 UBA-like domain UvrB PF12344.8 ETO26499.1 - 0.005 16.6 0.1 0.011 15.5 0.1 1.5 1 0 0 1 1 1 1 Ultra-violet resistance protein B Band_3_cyto PF07565.13 ETO26499.1 - 0.18 11.6 4.7 0.83 9.4 0.0 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain CENP-R PF06729.12 ETO26501.1 - 9 6.2 13.2 0.57 10.1 7.3 2.0 2 0 0 2 2 2 0 Kinetochore component, CENP-R Imm58 PF15581.6 ETO26502.1 - 0.0019 18.3 0.3 0.91 9.7 0.1 2.1 1 1 1 2 2 2 2 Immunity protein 58 U62_UL91 PF17442.2 ETO26502.1 - 0.049 13.6 0.0 0.096 12.7 0.0 1.5 1 0 0 1 1 1 0 Functional domain of U62 and UL91 proteins Kinesin PF00225.23 ETO26503.1 - 7.1e-28 97.5 0.1 7.9e-28 97.3 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain CAP_assoc_N PF14504.6 ETO26503.1 - 0.024 14.4 0.6 0.044 13.5 0.3 1.5 2 0 0 2 2 2 0 CAP-associated N-terminal DUF1461 PF07314.11 ETO26503.1 - 0.12 12.3 0.6 0.15 12.0 0.6 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) ubiquitin PF00240.23 ETO26504.1 - 2.6e-10 39.9 0.1 2.6e-10 39.9 0.1 3.1 3 0 0 3 3 3 1 Ubiquitin family Rad60-SLD PF11976.8 ETO26504.1 - 5e-07 29.4 0.1 1.9e-06 27.6 0.1 2.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like EF-hand_6 PF13405.6 ETO26504.1 - 0.00085 19.1 0.0 0.0045 16.8 0.0 2.3 1 0 0 1 1 1 1 EF-hand domain Orf78 PF06024.12 ETO26504.1 - 0.0015 18.8 0.1 0.0074 16.6 0.1 2.2 1 0 0 1 1 1 1 Orf78 (ac78) Kinesin PF00225.23 ETO26504.1 - 0.002 17.1 2.7 0.0027 16.7 0.0 2.6 4 0 0 4 4 4 1 Kinesin motor domain TBK1_ULD PF18396.1 ETO26504.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain EF-hand_5 PF13202.6 ETO26504.1 - 0.013 14.9 0.1 0.045 13.3 0.1 2.0 1 0 0 1 1 1 0 EF hand EF-hand_1 PF00036.32 ETO26504.1 - 0.015 14.8 0.1 0.073 12.7 0.1 2.3 1 0 0 1 1 1 0 EF hand DinB PF05163.12 ETO26504.1 - 0.11 12.4 0.4 0.29 11.0 0.4 1.7 1 0 0 1 1 1 0 DinB family DUF5436 PF17504.2 ETO26504.1 - 0.16 12.3 0.5 12 6.3 0.0 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5436) Kinesin_assoc PF16183.5 ETO26504.1 - 0.17 12.0 5.3 0.6 10.2 1.3 2.9 2 1 1 3 3 3 0 Kinesin-associated Effector_1 PF04518.12 ETO26504.1 - 0.3 10.1 8.1 0.13 11.3 3.1 2.3 2 0 0 2 2 2 0 Effector from type III secretion system COG5 PF10392.9 ETO26504.1 - 0.99 9.6 9.4 0.82 9.9 4.2 2.7 2 0 0 2 2 2 0 Golgi transport complex subunit 5 DUF16 PF01519.16 ETO26504.1 - 1.2 9.6 12.7 8.7 6.9 1.0 3.6 2 0 0 2 2 2 0 Protein of unknown function DUF16 DUF948 PF06103.11 ETO26504.1 - 1.4 9.2 6.9 9 6.6 1.2 2.9 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF1664 PF07889.12 ETO26504.1 - 1.5 8.9 11.4 23 5.1 6.6 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) EAP30 PF04157.16 ETO26504.1 - 7.1 5.8 10.8 0.62 9.3 1.0 3.5 3 1 1 4 4 4 0 EAP30/Vps36 family SlyX PF04102.12 ETO26504.1 - 8.6 7.1 14.3 2.4 8.9 1.3 3.8 2 1 1 3 3 3 0 SlyX zf-AN1 PF01428.16 ETO26505.1 - 0.001 19.1 7.7 0.0019 18.3 7.7 1.5 1 0 0 1 1 1 1 AN1-like Zinc finger Ank_5 PF13857.6 ETO26506.1 - 2.3e-06 27.8 0.0 6.4e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO26506.1 - 8.7e-05 23.0 0.0 0.00031 21.3 0.0 1.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO26506.1 - 0.00058 20.1 0.0 0.13 12.9 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ETO26506.1 - 0.012 16.0 0.0 0.42 11.2 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeat NPV_P10 PF05531.12 ETO26507.1 - 0.13 12.7 14.6 1.5 9.4 1.4 3.4 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein DUF2911 PF11138.8 ETO26507.1 - 1.3 8.9 10.2 0.28 11.0 4.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2911) Baculo_PEP_C PF04513.12 ETO26507.1 - 5.4 7.1 12.5 0.034 14.2 1.6 2.5 3 0 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus SDA1 PF05285.12 ETO26507.1 - 6.5 6.1 57.6 0.079 12.4 21.7 3.2 3 0 0 3 3 3 0 SDA1 PUB PF09409.10 ETO26509.1 - 0.28 11.1 6.7 0.1 12.6 1.4 2.8 2 0 0 2 2 2 0 PUB domain RNA_pol_Rpb2_7 PF04560.20 ETO26510.1 - 0.21 12.0 0.7 0.69 10.4 0.1 2.0 2 0 0 2 2 2 0 RNA polymerase Rpb2, domain 7 CHIPS PF11434.8 ETO26512.1 - 0.13 12.1 0.0 0.17 11.7 0.0 1.1 1 0 0 1 1 1 0 Chemotaxis-inhibiting protein CHIPS CAP_GLY PF01302.25 ETO26513.1 - 1.1e-14 54.2 2.8 2.1e-14 53.3 2.8 1.4 1 0 0 1 1 1 1 CAP-Gly domain TIG PF01833.24 ETO26513.1 - 0.15 12.2 0.4 1 9.5 0.1 2.0 2 0 0 2 2 2 0 IPT/TIG domain 2OG-FeII_Oxy_3 PF13640.6 ETO26514.1 - 3.7e-15 56.6 0.0 2e-14 54.2 0.0 2.2 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ETO26514.1 - 6.8e-05 23.3 0.6 0.002 18.6 0.0 2.7 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily PhyH PF05721.13 ETO26515.1 - 0.0053 17.0 2.5 0.0098 16.2 0.1 2.4 2 1 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) Herpes_UL55 PF04537.12 ETO26515.1 - 0.057 13.4 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Herpesvirus UL55 protein SUIM_assoc PF16619.5 ETO26515.1 - 0.12 12.5 10.9 0.35 11.0 8.9 2.4 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Roughex PF06020.11 ETO26515.1 - 0.7 8.9 11.4 0.44 9.6 8.6 1.9 2 0 0 2 2 2 0 Drosophila roughex protein Rubredoxin PF00301.20 ETO26515.1 - 0.76 9.9 5.4 6 7.0 0.5 3.2 3 0 0 3 3 3 0 Rubredoxin CDC45 PF02724.14 ETO26515.1 - 2.4 6.4 13.0 0.094 11.0 6.1 1.8 2 0 0 2 2 2 0 CDC45-like protein Presenilin PF01080.17 ETO26515.1 - 3.3 6.4 7.1 0.82 8.4 2.5 2.0 2 0 0 2 2 2 0 Presenilin Iwr1 PF08574.10 ETO26515.1 - 6.7 7.8 11.2 1.4 10.0 6.1 2.2 2 0 0 2 2 2 0 Transcription factor Iwr1 DUF4064 PF13273.6 ETO26516.1 - 0.1 12.9 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4064) TFIIF_alpha PF05793.12 ETO26518.1 - 0.0014 17.3 30.2 0.0014 17.3 30.2 2.1 2 0 0 2 2 2 2 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) INT_SG_DDX_CT_C PF15300.6 ETO26519.1 - 0.13 12.1 0.4 0.83 9.5 0.0 2.5 3 0 0 3 3 3 0 INTS6/SAGE1/DDX26B/CT45 C-terminus Mit_KHE1 PF10173.9 ETO26519.1 - 7.4 6.6 9.5 5 7.2 5.1 2.9 2 2 0 2 2 2 0 Mitochondrial K+-H+ exchange-related NLRC4_HD PF17889.1 ETO26520.1 - 0.02 15.2 0.0 0.093 13.1 0.0 2.1 1 0 0 1 1 1 0 NLRC4 helical domain UNC45-central PF11701.8 ETO26523.1 - 3.4e-06 27.1 8.0 0.021 14.8 0.8 5.0 4 1 0 4 4 4 2 Myosin-binding striated muscle assembly central EcsB PF05975.12 ETO26523.1 - 0.0034 16.3 0.3 0.0034 16.3 0.3 1.6 2 0 0 2 2 2 1 Bacterial ABC transporter protein EcsB HEAT_2 PF13646.6 ETO26523.1 - 0.13 12.7 0.0 2 8.9 0.0 3.1 3 0 0 3 3 3 0 HEAT repeats ParcG PF10274.9 ETO26523.1 - 0.33 11.1 2.6 3.1 7.9 0.2 3.4 4 0 0 4 4 4 0 Parkin co-regulated protein Ipi1_N PF12333.8 ETO26523.1 - 1.4 9.5 12.2 10 6.8 0.2 5.4 3 1 3 6 6 6 0 Rix1 complex component involved in 60S ribosome maturation Mannosyl_trans3 PF11051.8 ETO26524.1 - 7.7e-06 25.5 0.0 1e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative Lyase_1 PF00206.20 ETO26525.1 - 1.2e-08 34.7 0.0 1.5e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 Lyase Ras PF00071.22 ETO26526.1 - 9.2e-30 103.4 1.3 6e-14 52.0 0.2 2.6 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ETO26526.1 - 6.9e-23 81.1 0.1 1.6e-13 50.9 0.0 2.5 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO26526.1 - 1.3e-08 34.5 0.6 0.001 18.6 0.0 2.5 2 1 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO26526.1 - 4.5e-06 26.2 0.7 0.0091 15.4 0.0 2.1 2 0 0 2 2 2 2 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO26526.1 - 2.7e-05 23.8 0.4 0.005 16.4 0.1 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO26526.1 - 0.00058 19.9 0.1 0.0011 19.0 0.1 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_7 PF12775.7 ETO26526.1 - 0.011 15.3 0.1 0.03 13.8 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Chordopox_E11 PF06138.12 ETO26526.1 - 0.015 15.6 0.1 0.029 14.7 0.1 1.4 1 0 0 1 1 1 0 Chordopoxvirus E11 protein TniB PF05621.11 ETO26526.1 - 0.025 14.0 0.0 0.044 13.2 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein bZIP_1 PF00170.21 ETO26527.1 - 0.022 14.9 2.2 0.022 14.9 2.2 7.9 4 3 3 7 7 7 0 bZIP transcription factor Tetraspanin PF00335.20 ETO26527.1 - 0.068 12.9 0.0 0.12 12.1 0.0 1.5 1 1 0 1 1 1 0 Tetraspanin family Acyltransf_C PF16076.5 ETO26527.1 - 0.16 12.1 3.3 0.89 9.7 1.9 2.9 2 0 0 2 2 2 0 Acyltransferase C-terminus LPP PF04728.13 ETO26527.1 - 1.4 9.3 0.0 1.4 9.3 0.0 5.4 4 2 0 4 4 4 0 Lipoprotein leucine-zipper Cob_adeno_trans PF01923.18 ETO26527.1 - 3.7 7.7 24.2 2.1 8.5 0.1 3.9 2 1 0 2 2 2 0 Cobalamin adenosyltransferase PH PF00169.29 ETO26529.1 - 3e-12 47.0 0.2 3e-12 47.0 0.2 2.4 3 0 0 3 3 3 1 PH domain PH_6 PF15406.6 ETO26529.1 - 5.5e-05 23.4 1.1 0.00011 22.5 0.0 2.0 2 0 0 2 2 2 1 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO26529.1 - 0.0021 18.2 0.4 0.0073 16.4 0.4 1.9 1 0 0 1 1 1 1 Meiotic cell cortex C-terminal pleckstrin homology PH_13 PF16652.5 ETO26529.1 - 0.042 13.6 0.1 0.042 13.6 0.1 2.9 2 1 1 3 3 3 0 Pleckstrin homology domain GTP_EFTU_D2 PF03144.25 ETO26529.1 - 0.09 13.2 1.1 0.38 11.2 0.0 2.3 2 0 0 2 2 2 0 Elongation factor Tu domain 2 PH_4 PF15404.6 ETO26529.1 - 0.14 11.9 0.1 0.14 11.9 0.1 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain PH_9 PF15410.6 ETO26529.1 - 0.75 10.2 4.2 0.37 11.2 0.2 2.5 2 1 0 2 2 2 0 Pleckstrin homology domain DUF2956 PF11169.8 ETO26529.1 - 2.4 8.4 10.0 1.2 9.4 5.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) C2 PF00168.30 ETO26530.1 - 9.4e-13 48.4 0.0 8.3e-08 32.5 0.0 2.2 1 1 1 2 2 2 2 C2 domain Phage_SSB PF16773.5 ETO26530.1 - 0.085 12.9 1.9 38 4.4 0.0 3.1 3 0 0 3 3 3 0 Lactococcus phage single-stranded DNA binding protein WD40 PF00400.32 ETO26531.1 - 1e-36 124.2 17.5 1.5e-06 28.8 0.0 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26531.1 - 2.9e-12 46.7 0.2 0.0011 19.3 0.0 5.9 6 1 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO26531.1 - 5.8e-11 41.7 3.8 0.1 11.2 0.0 5.3 1 1 2 5 5 5 5 Nucleoporin Nup120/160 Read-through PF16814.5 ETO26531.1 - 0.016 15.1 1.0 0.12 12.2 0.1 2.9 3 1 1 4 4 4 0 Read-through domain Nucleoporin_N PF08801.11 ETO26531.1 - 0.083 11.6 6.7 0.31 9.7 0.1 3.2 3 2 1 4 4 4 0 Nup133 N terminal like DUF3825 PF12873.7 ETO26531.1 - 0.16 11.4 2.2 0.27 10.6 0.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3825) FYVE PF01363.21 ETO26531.1 - 1.2 9.3 9.3 1.5 9.0 4.7 2.8 2 0 0 2 2 2 0 FYVE zinc finger GABP-alpha PF11620.8 ETO26532.1 - 0.068 13.4 0.8 0.52 10.5 0.4 2.6 3 0 0 3 3 3 0 GA-binding protein alpha chain Presenilin PF01080.17 ETO26533.1 - 0.032 13.0 4.5 0.041 12.7 4.5 1.1 1 0 0 1 1 1 0 Presenilin TMEM214 PF10151.9 ETO26533.1 - 2.9 6.2 15.8 3.8 5.9 15.8 1.1 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator WD40 PF00400.32 ETO26535.1 - 4.2e-14 52.7 0.4 1e-06 29.3 0.2 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26535.1 - 4e-09 36.6 0.0 0.00046 20.4 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO26535.1 - 9.7e-05 21.8 2.8 0.0002 20.8 2.8 1.5 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETO26535.1 - 0.00024 20.2 0.1 0.021 13.8 0.0 2.3 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 ETO26536.1 - 8.8e-07 29.5 0.1 2.2e-06 28.3 0.1 1.7 1 0 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO26536.1 - 0.045 12.4 0.0 0.045 12.4 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 DUF1754 PF08555.10 ETO26538.1 - 4.4 8.2 22.4 2 9.2 1.2 3.5 3 0 0 3 3 3 0 Eukaryotic family of unknown function (DUF1754) Methyltransf_23 PF13489.6 ETO26539.1 - 3.9e-13 49.6 0.0 6.7e-13 48.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO26539.1 - 1.3e-08 35.5 0.0 5.2e-08 33.5 0.0 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO26539.1 - 5e-07 29.6 0.1 2.9e-06 27.1 0.1 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO26539.1 - 1.2e-06 29.1 0.0 3.1e-06 27.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO26539.1 - 9.2e-05 23.0 0.0 0.00022 21.8 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_4 PF02390.17 ETO26539.1 - 0.0003 20.3 0.0 0.00068 19.1 0.0 1.7 1 0 0 1 1 1 1 Putative methyltransferase Rubis-subs-bind PF09273.11 ETO26540.1 - 0.4 11.4 4.4 0.91 10.2 0.0 2.5 1 1 1 2 2 2 0 Rubisco LSMT substrate-binding SNF2_N PF00176.23 ETO26541.1 - 5.4e-31 107.6 0.1 1.3e-30 106.3 0.1 1.7 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO26541.1 - 1.1e-14 54.7 0.1 4.5e-14 52.7 0.0 2.1 2 0 0 2 2 2 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ETO26541.1 - 1.4e-05 24.5 0.1 1.4e-05 24.5 0.1 2.2 2 0 0 2 2 2 1 ERCC3/RAD25/XPB C-terminal helicase ResIII PF04851.15 ETO26541.1 - 0.012 15.6 1.9 0.83 9.6 0.0 3.5 4 0 0 4 4 4 0 Type III restriction enzyme, res subunit HDA2-3 PF11496.8 ETO26541.1 - 0.03 13.5 5.1 0.073 12.2 0.1 3.1 2 1 0 2 2 2 0 Class II histone deacetylase complex subunits 2 and 3 SspB PF04386.13 ETO26542.1 - 7.2 6.5 10.6 0.27 11.1 4.3 2.0 2 0 0 2 2 2 0 Stringent starvation protein B CSN8_PSD8_EIF3K PF10075.9 ETO26544.1 - 2.6e-25 89.1 0.8 3.8e-25 88.5 0.8 1.2 1 0 0 1 1 1 1 CSN8/PSMD8/EIF3K family Baculo_FP PF03258.14 ETO26544.1 - 0.014 15.6 0.0 0.028 14.6 0.0 1.5 1 0 0 1 1 1 0 Baculovirus FP protein YajC PF02699.15 ETO26545.1 - 0.096 12.6 0.4 0.096 12.6 0.4 2.2 3 0 0 3 3 3 0 Preprotein translocase subunit Lys_export PF03956.13 ETO26545.1 - 0.15 11.6 9.1 0.026 14.1 1.7 2.6 1 1 0 2 2 2 0 Lysine exporter LysO Vpu PF00558.19 ETO26545.1 - 8.6 6.2 5.9 1.5 8.7 0.2 2.6 3 1 0 3 3 3 0 Vpu protein DUF3394 PF11874.8 ETO26548.1 - 0.097 12.3 0.0 0.2 11.3 0.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3394) WD40 PF00400.32 ETO26549.1 - 1.2e-11 44.9 5.9 5.3e-06 27.1 0.4 5.0 3 2 1 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26549.1 - 8.1e-07 29.3 0.2 0.047 14.0 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26549.1 - 4.6e-05 22.5 0.2 0.058 12.3 0.2 3.3 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO26549.1 - 0.00016 21.5 1.7 1.1 9.3 0.0 4.3 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat RRM_1 PF00076.22 ETO26550.1 - 1.1e-28 98.8 0.4 7.4e-21 73.8 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ETO26550.1 - 1.3e-26 92.5 1.2 2.7e-26 91.6 1.2 1.5 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_occluded PF16842.5 ETO26550.1 - 9.1e-05 22.3 0.1 0.04 13.8 0.0 2.6 2 0 0 2 2 2 2 Occluded RNA-recognition motif RRM_5 PF13893.6 ETO26550.1 - 0.0089 15.6 0.0 0.076 12.6 0.0 2.3 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PHM7_cyt PF14703.6 ETO26550.1 - 0.15 12.3 6.0 3.4 7.9 0.3 4.0 3 1 0 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter CPSase_L_D2 PF02786.17 ETO26551.1 - 0.045 13.2 0.0 0.1 12.1 0.0 1.4 1 1 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain Rpp20 PF12328.8 ETO26551.1 - 5.1 7.0 10.2 2.5 8.0 0.3 2.5 2 0 0 2 2 2 0 Rpp20 subunit of nuclear RNase MRP and P PUF PF00806.19 ETO26552.1 - 1.1e-15 56.3 0.4 0.00024 20.6 0.0 4.1 4 0 0 4 4 4 3 Pumilio-family RNA binding repeat FemAB PF02388.16 ETO26552.1 - 0.055 12.3 0.7 0.084 11.7 0.7 1.2 1 0 0 1 1 1 0 FemAB family RasGEF PF00617.19 ETO26553.1 - 4.4e-10 40.0 0.0 6.3e-10 39.5 0.0 1.3 1 0 0 1 1 1 1 RasGEF domain RasGEF PF00617.19 ETO26554.1 - 2.5e-19 70.2 0.4 2.9e-19 70.0 0.4 1.0 1 0 0 1 1 1 1 RasGEF domain DUF5532 PF17673.1 ETO26554.1 - 0.0081 16.2 0.0 0.01 15.9 0.0 1.2 1 0 0 1 1 1 1 Family of unknown function (DUF5532) DUF4746 PF15928.5 ETO26554.1 - 0.1 12.0 0.1 0.25 10.8 0.1 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4746) DUF445 PF04286.12 ETO26555.1 - 0.0035 17.2 0.4 0.0041 17.0 0.4 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF445) RasGEF_N PF00618.20 ETO26555.1 - 0.019 15.2 0.0 0.057 13.7 0.0 1.8 1 1 0 1 1 1 0 RasGEF N-terminal motif W2 PF02020.18 ETO26555.1 - 0.087 13.0 1.5 0.14 12.4 1.5 1.3 1 0 0 1 1 1 0 eIF4-gamma/eIF5/eIF2-epsilon BrnA_antitoxin PF14384.6 ETO26555.1 - 0.17 12.4 2.4 1.2 9.6 0.1 2.2 2 0 0 2 2 2 0 BrnA antitoxin of type II toxin-antitoxin system Proteasome PF00227.26 ETO26556.1 - 2.3e-15 56.6 0.1 4.6e-15 55.6 0.1 1.4 1 0 0 1 1 1 1 Proteasome subunit Proteasome PF00227.26 ETO26557.1 - 4e-21 75.4 0.1 4.8e-21 75.1 0.1 1.1 1 0 0 1 1 1 1 Proteasome subunit Guanylate_kin PF00625.21 ETO26558.1 - 1.5e-44 151.9 0.1 8e-44 149.5 0.1 1.8 1 1 0 1 1 1 1 Guanylate kinase MMR_HSR1 PF01926.23 ETO26558.1 - 0.0021 18.1 0.0 0.004 17.2 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO26558.1 - 0.0044 16.9 0.0 0.0088 16.0 0.0 1.4 1 0 0 1 1 1 1 RsgA GTPase AAA_18 PF13238.6 ETO26558.1 - 0.005 17.4 0.0 0.011 16.3 0.0 1.6 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO26558.1 - 0.035 14.4 0.0 0.076 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO26558.1 - 0.043 14.2 0.0 0.054 13.9 0.0 1.4 1 1 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ETO26558.1 - 0.11 12.7 0.0 0.23 11.6 0.0 1.6 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO26558.1 - 0.13 12.7 0.1 0.43 11.0 0.0 1.8 2 0 0 2 2 2 0 RNA helicase ABC_tran PF00005.27 ETO26558.1 - 0.13 12.8 0.1 0.32 11.5 0.0 1.8 2 1 0 2 2 2 0 ABC transporter Isy1 PF06246.12 ETO26559.1 - 2.6e-70 236.9 11.1 3.2e-70 236.6 11.1 1.1 1 0 0 1 1 1 1 Isy1-like splicing family DUF2935 PF11155.8 ETO26559.1 - 0.16 12.3 1.6 0.2 12.0 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF2935) DAO PF01266.24 ETO26560.1 - 4.5e-41 141.6 0.0 5.3e-41 141.4 0.0 1.0 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_binding_2 PF00890.24 ETO26560.1 - 4.5e-05 22.7 0.7 0.0017 17.5 0.7 2.1 2 0 0 2 2 2 1 FAD binding domain FAD_oxidored PF12831.7 ETO26560.1 - 0.0029 17.0 1.5 0.0065 15.9 1.0 1.7 2 0 0 2 2 2 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO26560.1 - 0.052 12.8 0.1 0.085 12.1 0.1 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO26560.1 - 0.081 13.2 1.3 0.22 11.8 1.3 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain HI0933_like PF03486.14 ETO26560.1 - 0.089 11.5 0.3 0.13 10.9 0.3 1.2 1 0 0 1 1 1 0 HI0933-like protein Pyr_redox_3 PF13738.6 ETO26560.1 - 0.21 10.8 0.1 0.33 10.2 0.1 1.2 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_3 PF01494.19 ETO26560.1 - 0.26 10.5 0.4 0.42 9.8 0.4 1.3 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 ETO26560.1 - 0.26 10.3 0.3 2.4 7.1 0.2 2.0 2 0 0 2 2 2 0 Glucose inhibited division protein A Zip PF02535.22 ETO26561.1 - 1.5 8.0 7.0 0.081 12.1 1.0 1.9 2 1 0 2 2 2 0 ZIP Zinc transporter ATP19 PF11022.8 ETO26561.1 - 3.4 8.1 6.7 0.95 9.9 1.6 2.7 2 1 0 2 2 2 0 ATP synthase subunit K Cwf_Cwc_15 PF04889.12 ETO26562.1 - 0.0012 18.6 53.7 0.02 14.6 13.0 5.0 5 0 0 5 5 5 4 Cwf15/Cwc15 cell cycle control protein Nop25 PF09805.9 ETO26562.1 - 0.0023 18.4 6.7 0.0023 18.4 6.7 5.9 6 1 1 7 7 7 1 Nucleolar protein 12 (25kDa) FSA_C PF10479.9 ETO26562.1 - 0.12 10.5 14.1 0.21 9.7 14.1 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus SSP160 PF06933.11 ETO26562.1 - 0.14 10.3 16.0 0.22 9.7 16.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO26562.1 - 5.8 6.9 16.8 16 5.5 16.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FH2 PF02181.23 ETO26563.1 - 0.0064 15.7 3.0 0.0064 15.7 3.0 2.2 1 1 2 3 3 3 1 Formin Homology 2 Domain ERM PF00769.19 ETO26563.1 - 0.014 15.3 10.1 0.043 13.6 10.1 1.7 1 1 0 1 1 1 0 Ezrin/radixin/moesin family V-SNARE_C PF12352.8 ETO26563.1 - 0.065 13.5 0.4 1.3 9.4 0.1 2.6 2 0 0 2 2 2 0 Snare region anchored in the vesicle membrane C-terminus ATG16 PF08614.11 ETO26563.1 - 0.066 13.4 6.7 0.19 12.0 0.8 2.6 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) Sigma70_ner PF04546.13 ETO26563.1 - 0.075 12.9 0.2 0.075 12.9 0.2 2.3 2 1 0 2 2 2 0 Sigma-70, non-essential region YlqD PF11068.8 ETO26563.1 - 0.13 12.7 13.2 0.71 10.3 1.1 3.2 2 1 1 3 3 3 0 YlqD protein HAP1_N PF04849.13 ETO26563.1 - 0.35 10.0 12.9 0.022 14.0 4.9 2.3 2 1 0 2 2 2 0 HAP1 N-terminal conserved region COG5 PF10392.9 ETO26563.1 - 0.93 9.7 10.3 0.64 10.2 0.2 3.2 2 1 0 3 3 3 0 Golgi transport complex subunit 5 DivIC PF04977.15 ETO26563.1 - 1.6 8.5 10.4 0.62 9.9 0.2 3.3 3 1 1 4 4 4 0 Septum formation initiator Fib_alpha PF08702.10 ETO26563.1 - 4.2 7.5 15.9 1.8 8.7 1.5 3.1 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family SlyX PF04102.12 ETO26563.1 - 4.3 8.0 12.5 15 6.3 0.8 4.0 2 1 2 4 4 4 0 SlyX 60KD_IMP PF02096.20 ETO26563.1 - 6.6 6.6 7.4 1.4 8.8 1.4 2.4 2 0 0 2 2 2 0 60Kd inner membrane protein BRCA-2_OB3 PF09104.10 ETO26564.1 - 0.0023 17.6 0.1 0.0027 17.4 0.1 1.2 1 0 0 1 1 1 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 MCR_C PF04609.12 ETO26564.1 - 0.0072 15.4 0.1 0.0083 15.2 0.1 1.1 1 0 0 1 1 1 1 Methyl-coenzyme M reductase operon protein C Pox_VP8_L4R PF04498.12 ETO26564.1 - 0.046 13.3 0.3 0.055 13.1 0.3 1.2 1 0 0 1 1 1 0 Poxvirus nucleic acid binding protein VP8/L4R DMA PF03474.14 ETO26564.1 - 0.14 11.7 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 DMRTA motif ERAP1_C PF11838.8 ETO26567.1 - 5.9e-06 26.0 0.1 8e-06 25.6 0.1 1.2 1 0 0 1 1 1 1 ERAP1-like C-terminal domain SCIMP PF15050.6 ETO26567.1 - 0.00033 21.1 0.2 0.00052 20.5 0.2 1.3 1 0 0 1 1 1 1 SCIMP protein DAG1 PF05454.11 ETO26567.1 - 0.0049 16.3 0.0 0.0088 15.4 0.0 1.4 2 0 0 2 2 2 1 Dystroglycan (Dystrophin-associated glycoprotein 1) ResB PF05140.14 ETO26567.1 - 0.077 11.7 0.1 0.12 11.1 0.1 1.3 1 0 0 1 1 1 0 ResB-like family WBP-1 PF11669.8 ETO26567.1 - 0.18 12.5 0.0 0.3 11.7 0.0 1.4 1 0 0 1 1 1 0 WW domain-binding protein 1 TMEM52 PF14979.6 ETO26567.1 - 0.19 11.7 0.0 0.33 10.9 0.0 1.3 1 0 0 1 1 1 0 Transmembrane 52 DUF4381 PF14316.6 ETO26567.1 - 0.21 11.8 0.4 0.43 10.8 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Prominin PF05478.11 ETO26567.1 - 0.3 9.0 0.2 0.44 8.5 0.2 1.4 1 1 0 1 1 1 0 Prominin RCR PF12273.8 ETO26567.1 - 1.2 9.9 4.2 0.33 11.6 0.6 1.8 2 0 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red PhyH PF05721.13 ETO26568.1 - 8e-10 39.3 0.6 1.4e-06 28.7 0.1 2.9 2 1 1 3 3 3 2 Phytanoyl-CoA dioxygenase (PhyH) DLH PF01738.18 ETO26568.1 - 0.1 12.1 0.0 0.16 11.5 0.0 1.2 1 0 0 1 1 1 0 Dienelactone hydrolase family Utp13 PF08625.11 ETO26569.1 - 0.085 12.8 0.3 0.28 11.1 0.1 1.8 2 0 0 2 2 2 0 Utp13 specific WD40 associated domain WSN PF02206.18 ETO26569.1 - 0.11 12.4 0.3 0.25 11.3 0.1 1.7 2 0 0 2 2 2 0 Domain of unknown function A_deaminase PF00962.22 ETO26571.1 - 3e-24 85.9 0.0 6.6e-24 84.8 0.0 1.5 1 1 0 1 1 1 1 Adenosine/AMP deaminase Hist_deacetyl PF00850.19 ETO26572.1 - 3.7e-62 210.6 1.4 3.8e-43 148.1 0.0 2.6 3 0 0 3 3 3 2 Histone deacetylase domain DUF1256 PF06866.11 ETO26572.1 - 0.075 12.4 1.1 0.16 11.4 0.0 2.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1256) Mg_trans_NIPA PF05653.14 ETO26574.1 - 4e-06 26.2 0.0 5.8e-06 25.6 0.0 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA RRM_1 PF00076.22 ETO26575.1 - 5.3e-09 35.8 0.3 1.2e-08 34.6 0.3 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Kinesin PF00225.23 ETO26576.1 - 3.3e-46 157.8 0.1 4.1e-46 157.4 0.1 1.0 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO26576.1 - 1.4e-16 60.8 0.3 9.1e-15 54.9 0.0 2.4 2 0 0 2 2 2 1 Microtubule binding DUF2118 PF09891.9 ETO26576.1 - 0.012 15.6 0.0 0.047 13.6 0.0 1.9 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2118) AAA_16 PF13191.6 ETO26576.1 - 0.085 13.2 0.0 0.7 10.3 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_22 PF13401.6 ETO26576.1 - 0.15 12.3 0.1 0.57 10.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC2_membrane_3 PF12698.7 ETO26577.1 - 0.78 8.8 9.4 2.8 7.0 0.1 2.4 2 0 0 2 2 2 0 ABC-2 family transporter protein DUF2157 PF09925.9 ETO26579.1 - 0.12 12.2 0.0 0.12 12.1 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2157) F-box-like PF12937.7 ETO26580.1 - 0.00018 21.4 0.0 0.00042 20.2 0.0 1.6 1 0 0 1 1 1 1 F-box-like CCSAP PF15748.5 ETO26581.1 - 9 6.4 23.0 16 5.6 23.0 1.3 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated PIN_8 PF18476.1 ETO26582.1 - 0.0074 16.2 6.0 0.0082 16.0 6.0 1.1 1 0 0 1 1 1 1 PIN like domain Secretin_N_2 PF07655.13 ETO26582.1 - 0.014 15.9 13.0 0.022 15.3 13.0 1.3 1 0 0 1 1 1 0 Secretin N-terminal domain POX PF07526.11 ETO26582.1 - 0.024 15.2 5.3 0.028 15.0 5.3 1.2 1 0 0 1 1 1 0 Associated with HOX DNApol_Exo PF18136.1 ETO26582.1 - 0.05 12.7 8.1 0.12 11.5 7.9 1.6 1 1 1 2 2 2 0 DNA mitochondrial polymerase exonuclease domain Menin PF05053.13 ETO26582.1 - 0.063 11.6 6.1 0.066 11.6 6.1 1.0 1 0 0 1 1 1 0 Menin APCDDC PF14921.6 ETO26582.1 - 0.098 12.1 4.1 0.11 11.9 4.1 1.0 1 0 0 1 1 1 0 Adenomatosis polyposis coli down-regulated 1 PDDEXK_6 PF04720.12 ETO26582.1 - 0.11 12.4 7.8 0.12 12.3 7.8 1.1 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Zip PF02535.22 ETO26582.1 - 0.34 10.1 5.1 0.34 10.1 5.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO26582.1 - 0.51 11.3 4.0 0.74 10.8 4.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) DUF1635 PF07795.11 ETO26582.1 - 2.8 7.7 12.6 3.1 7.6 11.3 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1635) Presenilin PF01080.17 ETO26582.1 - 3.2 6.4 6.3 3.3 6.4 6.3 1.1 1 0 0 1 1 1 0 Presenilin HDA2-3 PF11496.8 ETO26583.1 - 2.3e-06 27.0 0.9 4.9e-05 22.6 0.0 2.2 2 1 0 2 2 2 2 Class II histone deacetylase complex subunits 2 and 3 SNF2_N PF00176.23 ETO26583.1 - 0.0001 21.2 0.2 0.00015 20.6 0.2 1.2 1 0 0 1 1 1 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO26583.1 - 0.00016 22.0 0.0 0.00035 20.9 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain SR-25 PF10500.9 ETO26584.1 - 0.12 12.0 40.4 0.029 14.0 27.8 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Med19 PF10278.9 ETO26584.1 - 0.82 9.6 15.8 1.3 8.9 3.2 2.4 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Coilin_N PF15862.5 ETO26584.1 - 4.4 7.1 21.3 1.9 8.3 9.3 2.4 2 0 0 2 2 2 0 Coilin N-terminus EF-hand_6 PF13405.6 ETO26585.1 - 0.0053 16.6 0.1 0.048 13.6 0.0 2.6 3 0 0 3 3 3 1 EF-hand domain EF-hand_7 PF13499.6 ETO26585.1 - 0.0087 16.5 0.1 0.025 15.0 0.1 1.8 1 1 0 1 1 1 1 EF-hand domain pair Pur_ac_phosph_N PF16656.5 ETO26585.1 - 0.009 16.6 0.1 0.018 15.6 0.1 1.5 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain EF-hand_1 PF00036.32 ETO26585.1 - 0.037 13.6 2.0 0.19 11.4 0.0 3.0 4 0 0 4 4 4 0 EF hand TauE PF01925.19 ETO26586.1 - 0.0022 17.6 0.1 0.0026 17.4 0.1 1.3 1 0 0 1 1 1 1 Sulfite exporter TauE/SafE T2SSF PF00482.23 ETO26586.1 - 0.38 10.7 2.3 0.5 10.3 0.0 2.2 3 0 0 3 3 3 0 Type II secretion system (T2SS), protein F ART PF01129.18 ETO26587.1 - 0.00077 18.8 0.4 0.0018 17.6 0.1 1.8 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase PyrI PF01948.18 ETO26587.1 - 0.67 10.2 4.7 2.5 8.4 0.0 2.9 3 0 0 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, allosteric domain HSBP1 PF06825.12 ETO26588.1 - 0.041 13.8 0.3 0.27 11.1 0.2 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Ubiq_cyt_C_chap PF03981.12 ETO26588.1 - 0.044 13.9 0.1 0.077 13.1 0.1 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone Kelch_1 PF01344.25 ETO26589.1 - 2.7e-06 26.9 0.4 0.18 11.4 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO26589.1 - 3.3e-06 26.9 3.3 0.74 9.9 0.8 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO26589.1 - 0.00015 21.7 0.2 0.0017 18.3 0.0 2.9 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO26589.1 - 0.0002 21.2 7.4 0.036 14.1 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO26589.1 - 0.00037 20.7 2.9 0.27 11.6 0.3 3.9 4 0 0 4 4 4 1 Kelch motif Peptidase_C14 PF00656.22 ETO26590.1 - 2.9e-15 56.9 0.5 5.1e-15 56.1 0.5 1.4 1 0 0 1 1 1 1 Caspase domain ABC_tran PF00005.27 ETO26592.1 - 5.1e-21 75.6 0.0 6.5e-21 75.3 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO26592.1 - 0.0019 18.1 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SbcCD_C PF13558.6 ETO26592.1 - 0.033 14.4 0.4 0.18 12.1 0.1 2.3 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit SMC_N PF02463.19 ETO26592.1 - 0.087 12.2 0.0 0.1 12.0 0.0 1.4 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain CLASP_N PF12348.8 ETO26593.1 - 0.013 15.1 0.1 0.025 14.2 0.1 1.4 1 0 0 1 1 1 0 CLASP N terminal EF-hand_1 PF00036.32 ETO26593.1 - 0.083 12.5 0.1 0.18 11.4 0.1 1.6 1 0 0 1 1 1 0 EF hand EF-hand_6 PF13405.6 ETO26593.1 - 0.11 12.5 0.0 0.27 11.3 0.0 1.6 1 0 0 1 1 1 0 EF-hand domain Na_trans_assoc PF06512.13 ETO26593.1 - 0.56 10.5 15.7 1.2 9.4 3.1 2.2 2 0 0 2 2 2 0 Sodium ion transport-associated CLASP_N PF12348.8 ETO26594.1 - 9.4e-10 38.4 0.7 1.4e-09 37.9 0.7 1.2 1 0 0 1 1 1 1 CLASP N terminal EF-hand_7 PF13499.6 ETO26594.1 - 8.9e-07 29.3 3.5 2.2e-06 28.0 3.5 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO26594.1 - 9.5e-05 22.0 2.7 0.12 12.4 1.2 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO26594.1 - 0.0009 19.0 0.8 0.0037 17.1 0.2 2.3 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO26594.1 - 0.0013 18.2 7.4 0.27 10.9 0.2 3.2 2 1 1 3 3 3 2 EF hand Dapper PF15268.6 ETO26595.1 - 0.0022 17.0 1.9 0.0027 16.7 1.9 1.0 1 0 0 1 1 1 1 Dapper DUF2507 PF10702.9 ETO26595.1 - 0.12 12.3 0.4 0.34 10.8 0.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2507) E1_dh PF00676.20 ETO26597.1 - 1.3e-63 214.7 0.1 1.6e-63 214.5 0.1 1.0 1 0 0 1 1 1 1 Dehydrogenase E1 component DXP_synthase_N PF13292.6 ETO26597.1 - 0.00039 19.7 0.0 0.0023 17.2 0.0 1.9 1 1 1 2 2 2 1 1-deoxy-D-xylulose-5-phosphate synthase TPP_enzyme_C PF02775.21 ETO26597.1 - 0.002 17.9 0.1 0.0064 16.3 0.1 1.7 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain RbpA PF13397.6 ETO26597.1 - 0.031 14.9 1.0 5.9 7.6 0.0 2.4 2 1 0 2 2 2 0 RNA polymerase-binding protein Ribosomal_L6e PF01159.19 ETO26598.1 - 3.6e-31 108.0 3.1 6e-31 107.3 3.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L6e Cytomega_UL84 PF06284.11 ETO26598.1 - 0.019 13.5 0.7 0.025 13.1 0.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein D123 PF07065.14 ETO26598.1 - 0.047 12.8 1.5 0.062 12.5 1.5 1.1 1 0 0 1 1 1 0 D123 OAD_gamma PF04277.13 ETO26598.1 - 1 10.0 3.4 2 9.0 3.4 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Nop53 PF07767.11 ETO26600.1 - 0.027 13.9 33.7 0.042 13.2 33.7 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) RNA_polI_A34 PF08208.11 ETO26600.1 - 0.045 13.9 38.5 0.047 13.8 36.2 1.9 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 VIR_N PF15912.5 ETO26600.1 - 0.22 11.1 12.2 0.31 10.6 12.2 1.2 1 0 0 1 1 1 0 Virilizer, N-terminal YL1 PF05764.13 ETO26600.1 - 0.34 11.0 37.4 0.33 11.0 36.2 1.4 1 1 0 1 1 1 0 YL1 nuclear protein CDC45 PF02724.14 ETO26600.1 - 0.37 9.0 26.5 0.52 8.5 26.5 1.2 1 0 0 1 1 1 0 CDC45-like protein Mucin PF01456.17 ETO26600.1 - 0.58 10.1 29.8 1.1 9.2 29.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein SID-1_RNA_chan PF13965.6 ETO26600.1 - 2.3 6.5 4.9 2.9 6.2 4.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CCDC71L PF15374.6 ETO26600.1 - 3.9 6.7 25.3 5.5 6.1 25.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 71L SR-25 PF10500.9 ETO26601.1 - 0.0092 15.6 11.6 0.012 15.3 11.6 1.0 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Myc_N PF01056.18 ETO26601.1 - 0.34 10.8 7.7 0.5 10.2 7.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region Mucin PF01456.17 ETO26601.1 - 0.78 9.7 11.1 1.1 9.3 11.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein UPF0560 PF10577.9 ETO26601.1 - 1.6 7.2 11.0 1.7 7.0 11.0 1.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0560 Menin PF05053.13 ETO26601.1 - 2 6.7 12.9 2.3 6.5 12.9 1.2 1 0 0 1 1 1 0 Menin HNF-1_N PF04814.13 ETO26601.1 - 2 9.0 11.1 2.6 8.6 11.1 1.1 1 0 0 1 1 1 0 Hepatocyte nuclear factor 1 (HNF-1), N terminus Presenilin PF01080.17 ETO26601.1 - 2.8 6.6 12.8 3.4 6.3 12.8 1.2 1 0 0 1 1 1 0 Presenilin PI3K_1B_p101 PF10486.9 ETO26601.1 - 2.8 5.6 9.8 3.3 5.4 9.8 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit FSA_C PF10479.9 ETO26601.1 - 6.3 4.8 10.5 7.6 4.5 10.5 1.0 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Vps51 PF08700.11 ETO26602.1 - 0.016 15.3 0.1 0.025 14.6 0.1 1.4 1 0 0 1 1 1 0 Vps51/Vps67 DASH_Dad3 PF08656.10 ETO26602.1 - 0.15 12.1 2.7 2.2 8.4 0.4 2.6 2 1 1 3 3 3 0 DASH complex subunit Dad3 TFIIA PF03153.13 ETO26603.1 - 0.043 13.8 31.5 0.054 13.5 31.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Red1 PF07964.11 ETO26603.1 - 6.9 4.8 48.5 8.5 4.5 48.5 1.1 1 0 0 1 1 1 0 Rec10 / Red1 Hamartin PF04388.12 ETO26603.1 - 8.5 4.9 31.9 11 4.6 31.9 1.0 1 0 0 1 1 1 0 Hamartin protein Myosin_head PF00063.21 ETO26604.1 - 1e-16 60.4 0.2 1.6e-16 59.7 0.2 1.3 1 1 0 1 1 1 1 Myosin head (motor domain) Kei1 PF08552.11 ETO26604.1 - 0.0038 17.1 0.0 0.0048 16.8 0.0 1.2 1 0 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Ion_trans PF00520.31 ETO26605.1 - 2.4e-13 49.9 29.2 2.5e-12 46.6 21.9 2.3 2 0 0 2 2 2 2 Ion transport protein PKD_channel PF08016.12 ETO26605.1 - 0.001 17.8 1.3 0.001 17.8 1.3 3.2 3 0 0 3 3 3 1 Polycystin cation channel COX2_TM PF02790.15 ETO26605.1 - 0.064 13.4 5.2 1.3 9.2 0.1 3.2 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF4577 PF15145.6 ETO26605.1 - 0.14 12.2 0.6 0.35 10.9 0.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4577) DUF3139 PF11337.8 ETO26605.1 - 1.4 9.6 15.7 8.7 7.1 0.4 3.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3139) Orf78 PF06024.12 ETO26605.1 - 1.7 9.0 0.0 1.7 9.0 0.0 3.1 3 0 0 3 3 3 0 Orf78 (ac78) DUF1218 PF06749.12 ETO26605.1 - 7 7.2 11.3 2 9.0 0.2 3.6 4 0 0 4 4 4 0 Protein of unknown function (DUF1218) zf-RING_2 PF13639.6 ETO26606.1 - 7.1e-05 23.1 1.6 0.00013 22.2 0.9 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETO26606.1 - 0.0016 18.4 0.4 0.0032 17.4 0.4 1.5 1 0 0 1 1 1 1 zinc-RING finger domain PHD PF00628.29 ETO26606.1 - 0.003 17.4 1.1 0.0065 16.3 1.1 1.6 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 ETO26606.1 - 0.0046 17.0 0.5 0.011 15.8 0.5 1.7 1 0 0 1 1 1 1 PHD-finger zf-C3HC4 PF00097.25 ETO26606.1 - 0.014 15.3 3.1 0.034 14.0 3.1 1.8 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO26606.1 - 0.058 13.7 3.4 0.18 12.1 3.4 1.9 1 1 0 1 1 1 0 RING-H2 zinc finger domain LEF-8 PF04941.12 ETO26606.1 - 0.068 11.4 0.3 0.089 11.0 0.3 1.1 1 0 0 1 1 1 0 Late expression factor 8 (LEF-8) Zn_ribbon_17 PF17120.5 ETO26606.1 - 0.27 10.9 2.0 0.37 10.5 0.3 2.1 1 1 1 2 2 2 0 Zinc-ribbon, C4HC2 type GrpE PF01025.19 ETO26606.1 - 0.34 10.6 1.7 0.6 9.8 1.0 1.6 1 1 1 2 2 2 0 GrpE zf-C3HC4_2 PF13923.6 ETO26606.1 - 0.78 9.6 3.6 5.8 6.8 3.6 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) SDA1 PF05285.12 ETO26608.1 - 0.0073 15.8 39.9 0.026 14.0 31.9 2.3 2 0 0 2 2 2 2 SDA1 DUF5358 PF17311.2 ETO26608.1 - 0.017 15.1 3.7 0.017 15.1 3.7 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5358) DUF2457 PF10446.9 ETO26608.1 - 1.9 7.5 50.9 0.047 12.8 37.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Secretin_N_2 PF07655.13 ETO26609.1 - 0.0013 19.2 4.1 0.0013 19.2 4.1 1.9 2 0 0 2 2 2 1 Secretin N-terminal domain MID_MedPIWI PF18296.1 ETO26609.1 - 0.031 14.1 2.7 0.63 9.8 0.3 2.3 2 0 0 2 2 2 0 MID domain of medPIWI Pex2_Pex12 PF04757.14 ETO26609.1 - 5.4 6.5 8.6 26 4.3 8.6 2.1 1 1 0 1 1 1 0 Pex2 / Pex12 amino terminal region Rft-1 PF04506.13 ETO26610.1 - 2.4e-59 201.5 7.5 2.7e-59 201.3 7.5 1.0 1 0 0 1 1 1 1 Rft protein Orf78 PF06024.12 ETO26610.1 - 0.33 11.3 3.6 0.74 10.2 0.0 2.8 3 0 0 3 3 3 0 Orf78 (ac78) DUF2663 PF10864.8 ETO26610.1 - 2 8.8 10.3 0.51 10.7 1.4 3.0 2 1 1 3 3 3 0 Protein of unknown function (DUF2663) DUF2418 PF10332.9 ETO26610.1 - 4.4 7.9 6.1 0.55 10.8 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2418) Fe-S_biosyn PF01521.20 ETO26611.1 - 1.1e-14 54.6 1.5 1.1e-14 54.6 0.1 1.7 2 1 0 2 2 2 1 Iron-sulphur cluster biosynthesis Saf_2TM PF18303.1 ETO26611.1 - 2.4 7.7 4.8 4.1 7.0 2.2 2.5 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain Pkinase_Tyr PF07714.17 ETO26614.1 - 0.00036 19.9 0.0 0.00086 18.7 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO26614.1 - 0.0012 18.2 0.0 0.0022 17.4 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain G-alpha PF00503.20 ETO26615.1 - 3.4e-18 65.9 0.5 3.9e-18 65.7 0.5 1.0 1 0 0 1 1 1 1 G-protein alpha subunit AAA_21 PF13304.6 ETO26615.1 - 0.0064 16.3 0.0 0.0081 16.0 0.0 1.1 1 0 0 1 1 1 1 AAA domain, putative AbiEii toxin, Type IV TA system Roc PF08477.13 ETO26615.1 - 0.011 16.0 0.0 0.015 15.5 0.0 1.2 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO26615.1 - 0.037 13.5 0.2 0.057 12.9 0.1 1.3 1 1 0 1 1 1 0 ADP-ribosylation factor family SRPRB PF09439.10 ETO26615.1 - 0.058 12.8 0.0 0.073 12.5 0.0 1.2 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit DSPc PF00782.20 ETO26616.1 - 4.3e-25 88.1 0.3 5.3e-25 87.8 0.3 1.1 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO26616.1 - 2.3e-05 24.1 0.1 2.7e-05 23.8 0.1 1.1 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETO26616.1 - 0.019 15.3 0.0 0.032 14.5 0.0 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain PTPlike_phytase PF14566.6 ETO26616.1 - 0.038 14.1 0.0 0.066 13.3 0.0 1.4 1 1 0 1 1 1 0 Inositol hexakisphosphate Y_phosphatase2 PF03162.13 ETO26616.1 - 0.045 13.3 0.5 0.07 12.7 0.5 1.6 1 1 0 1 1 1 0 Tyrosine phosphatase family PNISR PF15996.5 ETO26617.1 - 0.0019 18.5 0.9 0.0022 18.3 0.9 1.1 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Macoilin PF09726.9 ETO26617.1 - 0.081 11.5 7.8 0.071 11.7 7.8 1.0 1 0 0 1 1 1 0 Macoilin family GNAT_acetyltr_2 PF13718.6 ETO26617.1 - 0.092 12.1 2.4 0.12 11.8 2.4 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 rRNA_processing PF08524.11 ETO26617.1 - 0.096 12.7 9.7 0.14 12.1 9.7 1.2 1 0 0 1 1 1 0 rRNA processing Ctr PF04145.15 ETO26617.1 - 0.1 13.2 0.8 0.13 12.8 0.8 1.2 1 0 0 1 1 1 0 Ctr copper transporter family SLC12 PF03522.15 ETO26617.1 - 0.14 11.2 6.2 0.16 11.0 6.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 NPR3 PF03666.13 ETO26617.1 - 0.37 9.5 10.5 0.42 9.3 10.5 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Menin PF05053.13 ETO26617.1 - 0.63 8.3 10.4 0.68 8.2 10.4 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO26617.1 - 0.8 8.4 8.6 0.88 8.3 8.6 1.0 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 ETO26617.1 - 0.93 9.2 3.0 1.1 8.9 3.0 1.1 1 0 0 1 1 1 0 Connexin Band_3_cyto PF07565.13 ETO26617.1 - 1.3 8.7 4.2 1.5 8.5 4.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain RP-C_C PF11800.8 ETO26617.1 - 1.4 9.0 4.6 1.6 8.8 4.6 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Pex14_N PF04695.13 ETO26617.1 - 1.6 9.4 4.7 1.9 9.1 4.7 1.1 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region ALMT PF11744.8 ETO26617.1 - 1.8 7.3 7.2 2 7.1 7.2 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter GCD14 PF08704.10 ETO26617.1 - 2.9 7.5 5.7 3.9 7.1 5.7 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Neur_chan_memb PF02932.16 ETO26617.1 - 3.8 7.5 4.3 4.5 7.3 4.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2076 PF09849.9 ETO26617.1 - 5.1 7.1 14.7 6.4 6.7 14.7 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Pox_Ag35 PF03286.14 ETO26617.1 - 5.4 6.7 9.7 7.4 6.3 9.7 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ETO26617.1 - 8.2 5.5 9.0 9 5.4 9.0 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter HCO3_cotransp PF00955.21 ETO26617.1 - 9.2 5.0 7.2 11 4.7 7.2 1.0 1 0 0 1 1 1 0 HCO3- transporter family Glyco_hydro_47 PF01532.20 ETO26618.1 - 1.5e-40 139.5 0.1 2.1e-40 139.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Nic96 PF04097.14 ETO26619.1 - 1.8e-06 26.8 0.1 1.9e-06 26.7 0.1 1.1 1 0 0 1 1 1 1 Nup93/Nic96 SLC12 PF03522.15 ETO26620.1 - 0.12 11.4 7.8 0.13 11.3 7.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 ETO26620.1 - 0.13 12.3 0.7 0.16 12.0 0.7 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nic96 PF04097.14 ETO26621.1 - 1.5e-32 112.9 1.4 8.7e-23 80.6 0.1 2.8 2 1 0 2 2 2 2 Nup93/Nic96 MS_channel PF00924.18 ETO26621.1 - 0.072 12.6 0.0 0.13 11.8 0.0 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel Nic96 PF04097.14 ETO26622.1 - 2.4e-07 29.7 0.0 3.9e-07 28.9 0.0 1.4 1 1 0 1 1 1 1 Nup93/Nic96 DUF3439 PF11921.8 ETO26622.1 - 0.015 15.3 1.7 0.028 14.4 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO26622.1 - 0.1 10.8 3.0 0.14 10.4 3.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 MAGE_N PF12440.8 ETO26623.1 - 0.073 13.8 6.0 0.13 12.9 6.0 1.3 1 0 0 1 1 1 0 Melanoma associated antigen family N terminal SLS PF14611.6 ETO26623.1 - 0.62 9.8 4.9 0.7 9.7 4.7 1.3 1 1 0 1 1 1 0 Mitochondrial inner-membrane-bound regulator Dicty_REP PF05086.12 ETO26623.1 - 1.3 6.9 11.9 1.5 6.7 11.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PFK PF00365.20 ETO26624.1 - 2.5e-32 112.3 0.3 3.1e-32 112.1 0.3 1.0 1 0 0 1 1 1 1 Phosphofructokinase Viral_cys_rich PF08008.12 ETO26624.1 - 0.047 13.7 0.2 0.2 11.7 0.0 2.0 1 1 1 2 2 2 0 Viral cysteine rich Metallophos PF00149.28 ETO26625.1 - 5.6e-09 36.8 0.0 1.5e-08 35.4 0.0 1.7 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Ndc1_Nup PF09531.10 ETO26625.1 - 0.024 13.4 0.0 0.37 9.4 0.0 2.0 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup TIP49 PF06068.13 ETO26626.1 - 1.7e-75 254.4 3.4 5.4e-69 233.0 0.7 3.1 2 1 0 2 2 2 2 TIP49 P-loop domain TIP49_C PF17856.1 ETO26626.1 - 1.7e-22 79.3 0.6 3.9e-22 78.2 0.6 1.7 1 0 0 1 1 1 1 TIP49 AAA-lid domain AAA_22 PF13401.6 ETO26626.1 - 0.0081 16.4 0.0 0.023 15.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA PF00004.29 ETO26626.1 - 0.062 13.7 0.0 0.18 12.2 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Ni_hydr_CYTB PF01292.20 ETO26627.1 - 0.0031 17.1 10.6 0.0031 17.1 10.6 2.2 2 0 0 2 2 2 1 Prokaryotic cytochrome b561 Orf78 PF06024.12 ETO26627.1 - 0.0062 16.8 0.4 0.0062 16.8 0.4 3.9 4 1 1 5 5 5 1 Orf78 (ac78) UPF0542 PF15086.6 ETO26627.1 - 0.016 15.1 1.1 0.17 11.9 0.3 3.0 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 PBP1_TM PF14812.6 ETO26627.1 - 0.076 13.4 1.3 0.18 12.2 1.3 1.6 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ctr PF04145.15 ETO26627.1 - 0.19 12.4 4.9 0.27 11.8 0.2 2.8 2 1 0 2 2 2 0 Ctr copper transporter family NOA36 PF06524.12 ETO26627.1 - 0.41 9.9 3.6 0.64 9.3 3.6 1.2 1 0 0 1 1 1 0 NOA36 protein TPR_12 PF13424.6 ETO26628.1 - 3.2e-32 110.7 0.1 2.7e-13 50.0 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26628.1 - 1.5e-23 81.6 11.2 2.1e-06 27.3 1.6 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26628.1 - 7.2e-22 75.8 1.4 7.1e-05 22.6 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26628.1 - 8.1e-18 63.1 10.6 1.1e-05 25.3 0.4 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26628.1 - 2e-16 59.3 0.0 0.00014 21.6 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26628.1 - 2.6e-15 55.2 4.6 0.0012 18.8 0.0 4.7 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26628.1 - 1.6e-08 34.1 1.7 0.036 13.8 0.6 4.7 4 1 1 5 5 5 3 TPR repeat TPR_17 PF13431.6 ETO26628.1 - 3.6e-06 27.0 0.9 2.2 8.9 0.0 5.2 5 0 0 5 5 4 1 Tetratricopeptide repeat MIT PF04212.18 ETO26628.1 - 0.00012 22.1 0.9 0.49 10.5 0.0 3.5 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Peptidase_C14 PF00656.22 ETO26628.1 - 0.00018 21.5 1.1 0.00042 20.3 1.1 1.5 1 1 0 1 1 1 1 Caspase domain TPR_MalT PF17874.1 ETO26628.1 - 0.014 14.8 0.0 0.023 14.1 0.0 1.3 1 0 0 1 1 1 0 MalT-like TPR region DUF2225 PF09986.9 ETO26628.1 - 0.027 14.2 1.5 0.51 10.0 0.1 2.5 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_16 PF13432.6 ETO26628.1 - 0.029 15.0 0.0 48 4.7 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat His_Phos_2 PF00328.22 ETO26630.1 - 0.052 12.9 1.0 4.4 6.6 0.1 2.6 1 1 0 2 2 2 0 Histidine phosphatase superfamily (branch 2) F-box PF00646.33 ETO26632.1 - 5.5e-05 22.9 0.0 0.00016 21.5 0.0 1.8 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO26632.1 - 0.0024 17.7 0.0 0.0067 16.3 0.0 1.8 1 0 0 1 1 1 1 F-box-like Monellin PF09200.10 ETO26633.1 - 0.12 12.3 0.3 0.96 9.3 0.2 2.5 2 0 0 2 2 2 0 Monellin CLN3 PF02487.17 ETO26633.1 - 6 5.8 7.8 3.2 6.7 5.7 1.6 1 1 0 1 1 1 0 CLN3 protein DUF3502 PF12010.8 ETO26633.1 - 10 6.8 14.0 13 6.5 2.0 3.4 1 1 2 3 3 3 0 Domain of unknown function (DUF3502) DUF4695 PF15766.5 ETO26635.1 - 0.22 11.8 7.5 0.37 11.0 7.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4695) Spt20 PF12090.8 ETO26635.1 - 8.3 5.9 15.5 12 5.5 15.5 1.1 1 0 0 1 1 1 0 Spt20 family TRAPPC-Trs85 PF12739.7 ETO26636.1 - 1.1e-34 120.1 1.4 4.7e-34 118.0 1.4 1.8 1 1 0 1 1 1 1 ER-Golgi trafficking TRAPP I complex 85 kDa subunit CCDC106 PF15794.5 ETO26636.1 - 0.052 13.2 2.0 0.11 12.2 2.0 1.4 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 DUF1635 PF07795.11 ETO26636.1 - 1.3 8.8 7.3 3.8 7.3 7.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1635) Ku_C PF03730.14 ETO26637.1 - 0.0021 18.7 2.2 0.0021 18.7 2.2 2.9 3 1 0 3 3 3 1 Ku70/Ku80 C-terminal arm Cutinase PF01083.22 ETO26637.1 - 0.069 13.1 1.2 0.17 11.8 0.1 2.0 2 0 0 2 2 2 0 Cutinase DBC1 PF14443.6 ETO26637.1 - 2 8.4 5.0 0.77 9.7 0.7 2.5 3 0 0 3 3 3 0 DBC1 RNase_J_C PF17770.1 ETO26637.1 - 2 9.5 6.9 13 7.0 0.2 3.7 2 1 1 3 3 3 0 Ribonuclease J C-terminal domain Metal_resist PF13801.6 ETO26637.1 - 6.8 6.9 11.2 2 8.6 0.0 3.2 4 0 0 4 4 4 0 Heavy-metal resistance FapA PF03961.13 ETO26637.1 - 9.9 4.6 23.3 1.5 7.3 16.9 2.4 2 1 0 2 2 2 0 Flagellar Assembly Protein A Pox_RNA_Pol_22 PF05273.13 ETO26638.1 - 0.051 13.3 0.2 1 9.1 0.1 2.1 1 1 1 2 2 2 0 Poxvirus RNA polymerase 22 kDa subunit Tropomyosin PF00261.20 ETO26639.1 - 0.0049 16.3 1.5 0.0076 15.6 1.5 1.3 1 0 0 1 1 1 1 Tropomyosin ABC_tran PF00005.27 ETO26639.1 - 0.0055 17.2 0.5 0.0064 17.0 0.5 1.2 1 0 0 1 1 1 1 ABC transporter SpecificRecomb PF10136.9 ETO26639.1 - 0.015 13.7 0.3 0.016 13.5 0.3 1.0 1 0 0 1 1 1 0 Site-specific recombinase Exonuc_VII_L PF02601.15 ETO26639.1 - 0.016 14.8 3.8 0.019 14.6 3.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit AAA_32 PF13654.6 ETO26639.1 - 0.018 13.8 3.1 0.019 13.7 3.1 1.0 1 0 0 1 1 1 0 AAA domain Myb_DNA-binding PF00249.31 ETO26639.1 - 0.04 14.1 2.4 5.7 7.2 0.5 2.3 2 0 0 2 2 2 0 Myb-like DNA-binding domain BLOC1_2 PF10046.9 ETO26639.1 - 0.041 14.2 3.2 0.056 13.7 2.3 1.7 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Vac_Fusion PF02346.16 ETO26639.1 - 0.048 13.3 1.6 0.48 10.1 0.3 2.7 1 1 1 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DHR10 PF18595.1 ETO26639.1 - 0.066 13.3 0.3 0.066 13.3 0.3 2.2 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain DUF5446 PF17522.2 ETO26639.1 - 0.09 13.0 0.6 12 6.1 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5446) Gaa1 PF04114.14 ETO26639.1 - 0.14 11.2 0.5 0.21 10.6 0.5 1.1 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component FapA PF03961.13 ETO26639.1 - 0.17 10.5 2.9 0.19 10.3 2.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TMF_DNA_bd PF12329.8 ETO26639.1 - 0.61 10.1 8.4 0.3 11.1 5.3 2.0 3 0 0 3 3 3 0 TATA element modulatory factor 1 DNA binding FliD_N PF02465.18 ETO26639.1 - 0.78 10.5 5.0 3.8 8.3 5.0 2.2 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF4665 PF15679.5 ETO26640.1 - 0.08 13.6 0.4 0.08 13.6 0.4 3.3 4 0 0 4 4 4 0 Domain of unknown function (DUF4665) DUF4549 PF15082.6 ETO26640.1 - 0.55 10.0 3.4 0.4 10.5 0.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4549) HTH_WhiA PF02650.14 ETO26640.1 - 3.8 7.9 6.0 21 5.5 0.5 2.5 2 0 0 2 2 2 0 WhiA C-terminal HTH domain WD40 PF00400.32 ETO26641.1 - 3.4e-57 189.1 10.5 2.8e-11 43.8 0.5 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26641.1 - 2.1e-19 69.6 3.9 0.00089 19.5 0.0 5.9 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26641.1 - 4.9e-09 35.6 0.4 0.028 13.4 0.0 4.5 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO26641.1 - 8.1e-08 31.3 5.3 0.08 11.6 0.0 4.7 1 1 3 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO26641.1 - 1.5e-06 28.0 0.1 2.3 8.2 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO26641.1 - 9e-05 21.4 3.9 0.29 9.8 0.1 4.0 2 1 1 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 ETO26641.1 - 0.00014 21.3 0.1 0.051 12.9 0.0 3.2 1 1 3 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO26641.1 - 0.001 17.7 1.0 1.6 7.2 0.0 3.0 2 1 1 3 3 3 3 Cytochrome D1 heme domain Gmad1 PF10647.9 ETO26641.1 - 0.027 14.2 0.1 0.82 9.4 0.0 3.1 1 1 2 3 3 3 0 Lipoprotein LpqB beta-propeller domain Resistin PF06954.11 ETO26641.1 - 0.049 14.2 0.2 2.9 8.5 0.2 3.0 3 0 0 3 3 3 0 Resistin DUF1815 PF08844.10 ETO26641.1 - 0.096 12.7 1.0 13 5.9 0.0 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF1815) Proteasome_A_N PF10584.9 ETO26641.1 - 8.5 6.2 8.6 41 4.0 0.4 4.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Peptidase_M48 PF01435.18 ETO26642.1 - 4.3e-10 39.7 0.5 6.3e-10 39.2 0.5 1.2 1 0 0 1 1 1 1 Peptidase family M48 Transposase_1 PF01359.18 ETO26642.1 - 0.031 14.1 0.2 0.053 13.4 0.2 1.4 1 0 0 1 1 1 0 Transposase (partial DDE domain) VPS9 PF02204.18 ETO26643.1 - 1.2e-14 54.4 0.1 5.5e-14 52.2 0.0 2.1 2 0 0 2 2 2 1 Vacuolar sorting protein 9 (VPS9) domain CAP_GLY PF01302.25 ETO26643.1 - 7.1e-08 32.4 0.0 1.4e-07 31.4 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain SR-25 PF10500.9 ETO26643.1 - 0.0032 17.1 8.6 0.0032 17.1 8.6 2.1 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF3506 PF12014.8 ETO26643.1 - 0.1 12.6 0.5 0.66 10.0 0.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3506) SspB PF04386.13 ETO26643.1 - 0.16 11.9 3.7 1.4 8.7 1.9 2.5 2 0 0 2 2 2 0 Stringent starvation protein B Myc_N PF01056.18 ETO26643.1 - 0.19 11.6 8.7 0.031 14.2 3.9 1.9 2 0 0 2 2 2 0 Myc amino-terminal region MID_MedPIWI PF18296.1 ETO26643.1 - 0.26 11.1 8.7 1.3 8.7 0.2 2.3 2 0 0 2 2 2 0 MID domain of medPIWI Ribosomal_60s PF00428.19 ETO26643.1 - 0.85 10.3 7.2 0.18 12.4 2.7 2.2 2 0 0 2 2 2 0 60s Acidic ribosomal protein DCB PF16213.5 ETO26644.1 - 3.7e-07 30.0 11.1 1.7e-06 27.8 0.0 3.8 2 2 2 4 4 4 2 Dimerisation and cyclophilin-binding domain of Mon2 DUF3328 PF11807.8 ETO26644.1 - 0.012 15.4 0.1 0.019 14.8 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3328) SLC12 PF03522.15 ETO26644.1 - 0.23 10.4 14.2 0.048 12.7 10.9 1.6 2 1 0 2 2 2 0 Solute carrier family 12 gp32 PF08804.10 ETO26645.1 - 0.081 13.0 0.1 0.14 12.2 0.1 1.5 1 1 1 2 2 2 0 gp32 DNA binding protein like DUF996 PF06195.13 ETO26646.1 - 0.14 12.4 0.2 0.29 11.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF996) 2OG-FeII_Oxy_3 PF13640.6 ETO26647.1 - 1.5e-10 41.8 0.0 2.7e-10 41.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF3173 PF11372.8 ETO26647.1 - 0.052 13.4 0.1 0.11 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3173) SARAF PF06682.12 ETO26648.1 - 0.057 13.1 18.1 0.094 12.3 18.1 1.3 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis Macoilin PF09726.9 ETO26648.1 - 0.16 10.5 23.6 0.19 10.2 23.6 1.1 1 0 0 1 1 1 0 Macoilin family SOG2 PF10428.9 ETO26648.1 - 0.21 10.8 22.6 0.28 10.3 22.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein MDFI PF15316.6 ETO26648.1 - 1.7 8.7 25.2 0.53 10.3 10.3 2.7 1 1 1 2 2 2 0 MyoD family inhibitor Hema_esterase PF03996.15 ETO26649.1 - 0.029 14.2 0.0 0.032 14.0 0.0 1.0 1 0 0 1 1 1 0 Hemagglutinin esterase ESCRT-II PF05871.12 ETO26651.1 - 3e-42 144.2 0.4 3.9e-42 143.8 0.4 1.1 1 0 0 1 1 1 1 ESCRT-II complex subunit LisH PF08513.11 ETO26651.1 - 0.061 13.3 0.6 0.2 11.7 0.1 2.1 2 0 0 2 2 2 0 LisH AAA_lid_11 PF18198.1 ETO26652.1 - 9.5e-49 165.4 0.0 1.3e-48 164.9 0.0 1.2 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_C PF18199.1 ETO26652.1 - 6.4e-36 124.1 0.0 8.2e-36 123.8 0.0 1.1 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain DHC_N1 PF08385.12 ETO26653.1 - 2e-160 535.2 15.6 2e-160 535.2 15.6 4.7 4 1 0 4 4 2 1 Dynein heavy chain, N-terminal region 1 AAA_6 PF12774.7 ETO26653.1 - 1e-148 494.6 0.2 4.5e-147 489.3 0.0 3.7 3 0 0 3 3 3 1 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 ETO26653.1 - 7.4e-118 394.1 8.3 7.4e-118 394.1 8.3 6.1 6 2 2 8 8 7 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 ETO26653.1 - 1.9e-99 332.2 2.6 6.3e-99 330.5 0.5 3.3 3 0 0 3 3 2 1 P-loop containing dynein motor region D4 AAA_9 PF12781.7 ETO26653.1 - 2.4e-67 226.3 0.8 1.2e-66 224.0 0.8 2.3 1 0 0 1 1 1 1 ATP-binding dynein motor region AAA_7 PF12775.7 ETO26653.1 - 6.4e-65 218.1 2.5 7.2e-61 204.8 0.1 4.7 5 0 0 5 5 5 1 P-loop containing dynein motor region MT PF12777.7 ETO26653.1 - 8.9e-60 202.5 31.2 1e-58 199.0 31.2 2.4 1 1 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_heavy PF03028.15 ETO26653.1 - 1.8e-28 99.0 0.1 3.5e-25 88.4 0.1 3.7 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_1 PF17857.1 ETO26653.1 - 2.1e-24 85.6 0.2 2.1e-24 85.6 0.2 3.2 3 0 0 3 3 2 1 AAA+ lid domain AAA_5 PF07728.14 ETO26653.1 - 2.9e-20 72.7 0.2 3e-05 24.0 0.0 8.6 7 2 0 7 7 7 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 ETO26653.1 - 6.9e-18 65.0 2.6 3.9e-17 62.5 0.1 3.7 3 0 0 3 3 3 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 ETO26653.1 - 4e-07 30.6 1.2 0.94 9.8 0.0 5.5 5 0 0 5 5 4 2 AAA ATPase domain AAA_22 PF13401.6 ETO26653.1 - 9.8e-07 29.1 0.2 0.28 11.4 0.0 5.2 4 0 0 4 4 4 1 AAA domain AAA PF00004.29 ETO26653.1 - 1.5e-05 25.4 0.3 1.7 9.1 0.0 5.5 5 0 0 5 5 4 1 ATPase family associated with various cellular activities (AAA) AAA_30 PF13604.6 ETO26653.1 - 3.9e-05 23.4 1.3 0.077 12.7 0.0 3.9 4 0 0 4 4 3 1 AAA domain AAA_18 PF13238.6 ETO26653.1 - 4.6e-05 24.0 0.6 3.1 8.3 0.0 5.4 5 0 0 5 5 4 2 AAA domain AAA_33 PF13671.6 ETO26653.1 - 0.0014 18.8 0.3 1.3 9.2 0.0 4.1 4 0 0 4 4 3 1 AAA domain Sigma54_activat PF00158.26 ETO26653.1 - 0.0049 16.6 0.1 11 5.7 0.0 3.8 3 0 0 3 3 3 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETO26653.1 - 0.0087 16.4 0.2 3.8 8.0 0.0 4.1 3 0 0 3 3 3 1 RNA helicase rve_3 PF13683.6 ETO26653.1 - 0.019 14.7 1.3 19 5.1 0.0 4.7 4 0 0 4 4 4 0 Integrase core domain AAA_29 PF13555.6 ETO26653.1 - 0.044 13.5 0.3 47 3.8 0.0 3.7 3 0 0 3 3 3 0 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ETO26653.1 - 0.046 13.1 0.0 2.3 7.6 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 ETO26653.1 - 0.11 12.8 4.8 13 6.1 0.0 4.7 4 0 0 4 4 4 0 AAA domain ABC_tran PF00005.27 ETO26653.1 - 1.2 9.6 6.2 7.9 7.0 0.0 4.8 5 0 0 5 5 3 0 ABC transporter Retrotrans_gag PF03732.17 ETO26653.1 - 4.8 7.5 18.4 1.2 9.5 0.1 5.5 6 0 0 6 6 3 0 Retrotransposon gag protein ABC_tran_CTD PF16326.5 ETO26653.1 - 6.5 7.1 13.2 1.4 9.2 1.9 4.7 2 0 0 2 2 2 0 ABC transporter C-terminal domain FA_hydroxylase PF04116.13 ETO26654.1 - 0.073 13.4 0.4 0.11 12.8 0.2 1.6 1 1 0 1 1 1 0 Fatty acid hydroxylase superfamily WD40 PF00400.32 ETO26655.1 - 7.7e-15 55.0 8.4 2.9e-05 24.7 0.0 5.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26655.1 - 0.00063 20.0 1.3 1 9.7 0.0 3.9 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO26656.1 - 2e-48 161.3 17.3 3.6e-11 43.4 0.6 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26656.1 - 9.5e-19 67.5 2.2 0.00069 19.9 0.0 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO26656.1 - 1.2e-09 37.4 9.4 0.025 13.2 0.8 5.6 2 2 3 5 5 5 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO26656.1 - 2.3e-09 36.7 3.2 0.086 11.8 0.0 4.9 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO26656.1 - 0.00038 19.1 0.9 0.057 11.9 0.1 3.1 1 1 2 3 3 3 2 Cytochrome D1 heme domain PTB PF08416.13 ETO26656.1 - 0.013 15.7 0.6 0.55 10.4 0.0 2.9 1 1 1 2 2 2 0 Phosphotyrosine-binding domain SGL PF08450.12 ETO26656.1 - 0.025 14.1 0.3 0.053 13.1 0.1 1.6 2 0 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DPPIV_N PF00930.21 ETO26656.1 - 0.035 12.9 0.3 0.36 9.5 0.0 2.6 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Kelch_1 PF01344.25 ETO26657.1 - 6.8e-05 22.4 2.0 0.027 14.0 0.2 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO26657.1 - 0.00097 19.0 3.7 0.42 10.7 0.1 4.5 4 1 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO26657.1 - 0.0033 17.4 0.2 0.35 10.9 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO26657.1 - 0.0043 17.3 4.3 18 5.8 0.1 4.6 4 1 1 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO26657.1 - 0.031 14.6 0.1 0.35 11.2 0.0 2.8 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO26657.1 - 0.086 12.9 3.7 26 4.9 0.0 4.6 5 0 0 5 5 5 0 Kelch motif Pentaxin PF00354.17 ETO26657.1 - 0.29 10.8 5.5 0.41 10.3 0.1 2.9 3 0 0 3 3 3 0 Pentaxin family U-box PF04564.15 ETO26658.1 - 3.4e-09 36.8 0.3 1.8e-08 34.4 0.0 2.4 2 0 0 2 2 2 1 U-box domain Kelch_6 PF13964.6 ETO26658.1 - 3.7e-08 33.4 1.1 0.00021 21.4 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO26658.1 - 5.1e-08 32.4 1.6 4.2e-06 26.2 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO26658.1 - 4.6e-05 23.3 0.2 0.00024 21.1 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO26658.1 - 0.00078 19.7 0.1 0.0053 17.0 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO26658.1 - 0.066 13.2 0.3 3.7 7.7 0.0 2.9 3 0 0 3 3 3 0 Kelch motif U-box PF04564.15 ETO26659.1 - 2.7e-08 33.9 0.6 1.2e-07 31.8 0.0 2.4 2 1 0 2 2 2 1 U-box domain Kelch_1 PF01344.25 ETO26659.1 - 2.7e-07 30.1 2.7 0.00086 18.8 0.1 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO26659.1 - 3.4e-07 30.3 5.4 0.00015 21.9 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO26659.1 - 9.2e-06 25.6 0.3 0.00014 21.8 0.0 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO26659.1 - 0.00045 20.4 0.1 0.0092 16.3 0.0 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO26659.1 - 0.015 15.3 0.3 0.18 11.8 0.1 2.9 4 0 0 4 4 4 0 Kelch motif PAZ PF02170.22 ETO26660.1 - 1.2e-06 28.3 0.4 2.5e-06 27.4 0.4 1.5 1 0 0 1 1 1 1 PAZ domain Piwi PF02171.17 ETO26660.1 - 0.00037 19.8 0.0 0.00064 19.1 0.0 1.4 1 0 0 1 1 1 1 Piwi domain Sod_Fe_C PF02777.18 ETO26660.1 - 0.16 12.2 0.0 0.36 11.0 0.0 1.6 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, C-terminal domain DUF929 PF06053.11 ETO26660.1 - 0.85 8.9 3.1 1.5 8.0 3.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF929) EphA2_TM PF14575.6 ETO26660.1 - 3.8 8.4 4.8 0.69 10.8 0.3 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Chorion_3 PF05387.11 ETO26661.1 - 0.039 13.6 2.7 0.066 12.9 2.7 1.3 1 0 0 1 1 1 0 Chorion family 3 DUF2101 PF09874.9 ETO26661.1 - 1.9 8.1 5.2 3.8 7.2 5.2 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2101) cobW PF02492.19 ETO26662.1 - 4.3e-44 150.2 0.2 7.4e-44 149.4 0.2 1.3 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain CobW_C PF07683.14 ETO26662.1 - 3.5e-09 36.5 0.0 8.7e-09 35.2 0.0 1.6 1 0 0 1 1 1 1 Cobalamin synthesis protein cobW C-terminal domain KTI12 PF08433.10 ETO26662.1 - 7.8e-05 22.3 0.0 0.00018 21.1 0.0 1.6 1 0 0 1 1 1 1 Chromatin associated protein KTI12 MobB PF03205.14 ETO26662.1 - 9.2e-05 22.3 0.1 0.00026 20.9 0.1 1.8 1 0 0 1 1 1 1 Molybdopterin guanine dinucleotide synthesis protein B RsgA_GTPase PF03193.16 ETO26662.1 - 9.8e-05 22.3 2.0 0.043 13.7 0.3 2.5 2 0 0 2 2 2 2 RsgA GTPase MeaB PF03308.16 ETO26662.1 - 0.00054 19.0 0.2 0.0016 17.5 0.0 1.8 2 0 0 2 2 2 1 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 ETO26662.1 - 0.0017 18.3 0.6 0.0037 17.2 0.2 1.8 2 0 0 2 2 2 1 NTPase AAA_16 PF13191.6 ETO26662.1 - 0.0017 18.7 0.0 0.0035 17.7 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain T2SSE PF00437.20 ETO26662.1 - 0.0025 17.0 1.1 0.005 15.9 0.4 1.7 2 0 0 2 2 2 1 Type II/IV secretion system protein AAA_22 PF13401.6 ETO26662.1 - 0.0045 17.3 0.0 0.011 16.0 0.0 1.7 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 ETO26662.1 - 0.0077 15.9 0.1 0.02 14.5 0.1 1.7 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain MMR_HSR1 PF01926.23 ETO26662.1 - 0.0081 16.2 0.7 0.025 14.6 0.1 2.4 2 1 0 2 2 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 ETO26662.1 - 0.0097 16.4 0.8 0.042 14.4 0.1 2.4 2 0 0 2 2 2 1 AAA domain DUF87 PF01935.17 ETO26662.1 - 0.011 15.8 1.8 0.011 15.8 1.8 2.5 2 1 0 2 2 2 0 Helicase HerA, central domain ATPase_2 PF01637.18 ETO26662.1 - 0.012 15.6 2.0 0.078 12.9 0.1 2.3 2 0 0 2 2 2 0 ATPase domain predominantly from Archaea TsaE PF02367.17 ETO26662.1 - 0.015 15.3 0.0 0.046 13.7 0.0 1.8 2 0 0 2 2 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SRPRB PF09439.10 ETO26662.1 - 0.015 14.7 0.6 0.086 12.3 0.1 2.2 2 0 0 2 2 2 0 Signal recognition particle receptor beta subunit ATP_bind_1 PF03029.17 ETO26662.1 - 0.019 14.7 0.1 0.086 12.6 0.0 2.0 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein AAA_14 PF13173.6 ETO26662.1 - 0.029 14.4 0.0 0.078 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO26662.1 - 0.034 14.3 0.0 0.069 13.3 0.0 1.6 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ETO26662.1 - 0.036 13.4 0.0 0.079 12.2 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin TrwB_AAD_bind PF10412.9 ETO26662.1 - 0.036 13.0 0.0 0.072 12.0 0.0 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain NACHT PF05729.12 ETO26662.1 - 0.037 13.9 0.0 0.071 13.0 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Viral_helicase1 PF01443.18 ETO26662.1 - 0.04 13.7 0.5 0.078 12.7 0.1 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase AAA_23 PF13476.6 ETO26662.1 - 0.055 14.0 0.1 0.055 14.0 0.1 2.5 2 1 0 2 2 1 0 AAA domain AAA_29 PF13555.6 ETO26662.1 - 0.056 13.2 0.1 0.12 12.2 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain APS_kinase PF01583.20 ETO26662.1 - 0.093 12.6 0.0 0.18 11.7 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase CENP-B_dimeris PF09026.10 ETO26662.1 - 1.2 9.6 6.9 1.8 9.0 3.7 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain EHD_N PF16880.5 ETO26663.1 - 8.8e-14 51.1 1.3 2.1e-13 49.9 1.3 1.7 1 0 0 1 1 1 1 N-terminal EH-domain containing protein Dynamin_N PF00350.23 ETO26663.1 - 1.4e-11 44.8 0.0 4.3e-11 43.2 0.0 1.8 1 1 0 1 1 1 1 Dynamin family MMR_HSR1 PF01926.23 ETO26663.1 - 1.7e-05 24.9 0.0 0.0001 22.3 0.0 2.1 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF5600 PF18150.1 ETO26663.1 - 4.2e-05 24.1 0.0 0.00012 22.6 0.0 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5600) RsgA_GTPase PF03193.16 ETO26663.1 - 0.019 14.9 0.0 2.4 8.0 0.0 3.1 4 0 0 4 4 4 0 RsgA GTPase Sdh_cyt PF01127.22 ETO26664.1 - 6e-05 23.1 4.8 6e-05 23.1 4.8 2.3 2 1 0 2 2 2 1 Succinate dehydrogenase/Fumarate reductase transmembrane subunit LAGLIDADG_WhiA PF14527.6 ETO26664.1 - 0.03 14.4 0.0 0.075 13.1 0.0 1.7 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain DUF4200 PF13863.6 ETO26665.1 - 1.5e-08 35.0 33.3 1.5e-08 35.0 33.3 3.2 3 1 0 3 3 3 1 Domain of unknown function (DUF4200) DUF4407 PF14362.6 ETO26665.1 - 4.6 6.5 14.0 7.2 5.9 14.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Phage_lysozyme2 PF18013.1 ETO26665.1 - 8.8 6.3 15.2 0.15 12.0 4.7 2.4 1 1 2 3 3 3 0 Phage tail lysozyme YkyA PF10368.9 ETO26665.1 - 9.8 5.8 41.9 10 5.7 7.6 3.1 1 1 1 2 2 2 0 Putative cell-wall binding lipoprotein DUF4320 PF14208.6 ETO26666.1 - 0.21 11.7 1.3 3.4 7.8 0.3 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4320) DUF4520 PF15016.6 ETO26667.1 - 1.2e-06 28.5 0.3 9.3e-06 25.7 0.0 2.6 2 2 0 2 2 2 1 Domain of unknown function (DUF4520) Brix PF04427.18 ETO26668.1 - 2.4e-07 31.1 1.8 2.9e-07 30.8 1.8 1.2 1 0 0 1 1 1 1 Brix domain DUF1168 PF06658.12 ETO26669.1 - 0.14 12.0 8.4 0.19 11.5 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) TPH PF13868.6 ETO26670.1 - 7e-34 116.9 125.0 3.8e-32 111.2 117.3 3.1 3 0 0 3 3 3 2 Trichohyalin-plectin-homology domain Spc7 PF08317.11 ETO26672.1 - 1.2e-05 24.4 10.4 1.4e-05 24.2 10.4 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF4349 PF14257.6 ETO26672.1 - 0.0003 20.3 1.1 0.00038 20.0 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4349) Baculo_PEP_C PF04513.12 ETO26672.1 - 0.009 16.1 14.2 0.12 12.4 7.7 2.1 1 1 1 2 2 2 2 Baculovirus polyhedron envelope protein, PEP, C terminus DUF1640 PF07798.11 ETO26672.1 - 0.014 15.5 15.2 0.15 12.1 6.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1640) T2SSS_2 PF16549.5 ETO26672.1 - 0.014 15.4 4.1 0.16 12.0 0.2 2.3 1 1 0 2 2 2 0 Type II secretion system (T2SS) pilotin, S protein Ribosomal_L31e PF01198.19 ETO26672.1 - 0.016 15.4 4.7 0.25 11.6 0.2 2.6 1 1 1 2 2 2 0 Ribosomal protein L31e DUF4407 PF14362.6 ETO26672.1 - 0.024 14.0 1.7 0.029 13.7 1.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HsbA PF12296.8 ETO26672.1 - 0.032 14.7 0.5 0.12 12.8 0.4 1.9 1 1 1 2 2 2 0 Hydrophobic surface binding protein A Fez1 PF06818.15 ETO26672.1 - 0.038 14.5 9.6 0.053 14.0 9.6 1.3 1 0 0 1 1 1 0 Fez1 NPV_P10 PF05531.12 ETO26672.1 - 0.047 14.2 13.7 6.8 7.2 12.7 3.2 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Seryl_tRNA_N PF02403.22 ETO26672.1 - 0.047 13.9 13.8 0.085 13.1 8.5 2.6 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Mgr1 PF08602.10 ETO26672.1 - 0.056 12.3 6.1 0.061 12.2 6.1 1.1 1 0 0 1 1 1 0 Mgr1-like, i-AAA protease complex subunit Exonuc_VII_L PF02601.15 ETO26672.1 - 0.069 12.7 6.8 0.083 12.4 6.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3584 PF12128.8 ETO26672.1 - 0.087 10.3 10.7 0.11 10.0 10.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DivIVA PF05103.13 ETO26672.1 - 0.091 12.8 10.0 0.15 12.1 10.0 1.3 1 0 0 1 1 1 0 DivIVA protein PI3K_P85_iSH2 PF16454.5 ETO26672.1 - 0.098 12.3 14.7 0.19 11.3 10.2 2.1 1 1 1 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain FUSC-like PF12805.7 ETO26672.1 - 0.099 11.7 2.7 0.15 11.1 2.7 1.3 1 0 0 1 1 1 0 FUSC-like inner membrane protein yccS Prominin PF05478.11 ETO26672.1 - 0.12 10.3 14.7 0.14 10.1 13.7 1.6 1 1 0 1 1 1 0 Prominin Serine_rich PF08824.10 ETO26672.1 - 0.18 11.8 9.1 0.48 10.4 9.1 1.7 1 1 0 1 1 1 0 Serine rich protein interaction domain Nas2_N PF18265.1 ETO26672.1 - 0.2 11.6 11.2 8.1 6.4 5.9 3.3 1 1 1 2 2 2 0 Nas2 N_terminal domain BLOC1_2 PF10046.9 ETO26672.1 - 0.24 11.7 15.8 0.53 10.6 10.2 2.3 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF445 PF04286.12 ETO26672.1 - 0.25 11.1 10.0 0.32 10.8 10.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF445) ApoO PF09769.9 ETO26672.1 - 0.26 11.3 6.5 2 8.4 1.2 2.3 1 1 1 2 2 2 0 Apolipoprotein O Mod_r PF07200.13 ETO26672.1 - 0.46 10.6 12.9 2.4 8.2 12.2 2.1 1 1 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF1664 PF07889.12 ETO26672.1 - 0.47 10.5 12.2 2.6 8.1 12.2 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Phage_GPO PF05929.11 ETO26672.1 - 0.48 10.0 7.2 0.62 9.6 7.2 1.2 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HIP1_clath_bdg PF16515.5 ETO26672.1 - 0.57 10.8 12.8 0.81 10.3 11.5 1.9 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1216 PF06746.11 ETO26672.1 - 0.6 10.1 10.5 1.3 9.1 5.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1216) Fib_alpha PF08702.10 ETO26672.1 - 0.64 10.2 16.5 2.1 8.5 16.3 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family ATPase PF06745.13 ETO26672.1 - 0.65 9.3 7.0 2.6 7.3 1.5 2.1 1 1 1 2 2 2 0 KaiC CENP-O PF09496.10 ETO26672.1 - 0.72 9.8 6.7 1.2 9.1 6.7 1.4 1 1 0 1 1 1 0 Cenp-O kinetochore centromere component APG6_N PF17675.1 ETO26672.1 - 0.76 10.3 11.8 2.1 8.9 11.8 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region FapA PF03961.13 ETO26672.1 - 0.77 8.3 13.4 2 6.9 13.4 1.6 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF2203 PF09969.9 ETO26672.1 - 0.91 10.3 7.9 14 6.4 7.9 2.1 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) YtxH PF12732.7 ETO26672.1 - 1.3 9.6 6.0 1.1e+02 3.5 6.0 2.7 1 1 0 1 1 1 0 YtxH-like protein DHR10 PF18595.1 ETO26672.1 - 1.5 8.9 13.7 1.3 9.1 9.6 2.2 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Syntaxin-6_N PF09177.11 ETO26672.1 - 1.6 9.3 10.2 2.5 8.7 8.6 2.0 1 1 1 2 2 2 0 Syntaxin 6, N-terminal Allexi_40kDa PF05549.11 ETO26672.1 - 1.8 8.0 10.2 1.3 8.5 8.4 1.6 1 1 1 2 2 2 0 Allexivirus 40kDa protein DUF5339 PF17274.2 ETO26672.1 - 1.9 9.4 9.2 1.4 9.8 1.0 2.8 1 1 1 2 2 2 0 Family of unknown function (DUF5339) MnmE_helical PF12631.7 ETO26672.1 - 2.6 8.2 6.9 6.4 6.9 2.5 2.1 1 1 1 2 2 2 0 MnmE helical domain MCU PF04678.13 ETO26672.1 - 3 7.9 11.6 0.45 10.6 6.8 1.9 1 1 1 2 2 2 0 Mitochondrial calcium uniporter FlaC_arch PF05377.11 ETO26672.1 - 4 7.9 16.2 2.5 8.6 4.3 3.5 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) DASH_Dam1 PF08653.10 ETO26672.1 - 5.3 6.9 6.6 2.8 7.8 0.9 2.9 1 1 2 3 3 3 0 DASH complex subunit Dam1 Nucleoside_tran PF01733.18 ETO26673.1 - 5.9e-14 52.2 0.5 5.9e-14 52.2 0.5 2.3 2 1 1 3 3 3 1 Nucleoside transporter Nop14 PF04147.12 ETO26673.1 - 0.13 10.5 18.9 0.14 10.3 18.9 1.1 1 0 0 1 1 1 0 Nop14-like family LAP1C PF05609.12 ETO26673.1 - 0.15 11.1 14.0 0.18 10.8 14.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SDA1 PF05285.12 ETO26673.1 - 1.1 8.6 21.5 1.7 8.0 21.5 1.3 1 0 0 1 1 1 0 SDA1 GREB1 PF15782.5 ETO26673.1 - 2.6 5.1 13.8 3.3 4.7 13.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer PDDEXK_6 PF04720.12 ETO26673.1 - 4.2 7.2 8.7 7.2 6.5 8.7 1.4 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Macoilin PF09726.9 ETO26673.1 - 8.4 4.8 22.9 10 4.5 22.9 1.1 1 0 0 1 1 1 0 Macoilin family CAP_GLY PF01302.25 ETO26674.1 - 1.9e-12 47.0 0.1 3.9e-12 46.0 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain RhoGEF PF00621.20 ETO26675.1 - 1.4e-09 38.5 8.7 1.4e-09 38.5 8.7 2.2 2 1 0 2 2 2 1 RhoGEF domain CGGC PF08821.11 ETO26675.1 - 0.091 13.0 0.2 0.16 12.2 0.2 1.4 1 0 0 1 1 1 0 CGGC domain Med27 PF11571.8 ETO26675.1 - 6.7 7.2 9.1 7.6 7.0 0.1 3.2 3 1 0 3 3 3 0 Mediator complex subunit 27 RabGAP-TBC PF00566.18 ETO26676.1 - 0.00066 19.4 0.1 0.00072 19.3 0.1 1.1 1 0 0 1 1 1 1 Rab-GTPase-TBC domain DUF2818 PF10993.8 ETO26676.1 - 0.025 15.1 0.3 0.033 14.7 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2818) TIP49_C PF17856.1 ETO26676.1 - 0.06 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 TIP49 AAA-lid domain G-alpha PF00503.20 ETO26677.1 - 7.8e-05 22.0 0.9 0.00013 21.3 0.1 1.6 1 1 1 2 2 2 1 G-protein alpha subunit CoaE PF01121.20 ETO26678.1 - 1.4e-43 148.7 0.0 1.8e-43 148.3 0.0 1.1 1 0 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ETO26678.1 - 7.4e-05 23.3 1.0 0.00025 21.6 0.6 2.0 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETO26678.1 - 0.082 13.1 0.2 0.39 10.9 0.2 2.2 1 1 0 1 1 1 0 AAA domain ExoD PF06055.12 ETO26678.1 - 0.15 11.4 0.1 0.32 10.4 0.1 1.5 1 0 0 1 1 1 0 Exopolysaccharide synthesis, ExoD SKI PF01202.22 ETO26678.1 - 0.2 11.8 0.6 18 5.4 0.0 2.3 2 0 0 2 2 2 0 Shikimate kinase WDCP PF15390.6 ETO26679.1 - 0.53 8.6 7.0 0.65 8.3 7.0 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Presenilin PF01080.17 ETO26679.1 - 2.2 6.9 10.0 2.7 6.7 10.0 1.1 1 0 0 1 1 1 0 Presenilin Ank_2 PF12796.7 ETO26680.1 - 3.5e-16 59.6 8.0 1.4e-08 35.2 0.9 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO26680.1 - 8.7e-14 51.7 7.4 1.3e-05 25.6 0.2 3.9 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO26680.1 - 9.9e-13 48.0 5.8 0.0016 18.7 0.0 3.8 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO26680.1 - 2.7e-11 42.6 7.3 0.02 15.4 0.0 4.9 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ETO26680.1 - 9.4e-09 35.3 7.8 0.1 13.1 0.5 4.8 5 0 0 5 5 5 4 Ankyrin repeat Ank_2 PF12796.7 ETO26681.1 - 7.1e-09 36.1 0.0 1.8e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO26681.1 - 2.1e-08 34.2 0.2 1.5e-07 31.5 0.3 2.4 1 1 1 2 2 2 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO26681.1 - 6.9e-08 32.9 0.0 2.2e-07 31.3 0.0 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO26681.1 - 1.5e-07 31.5 0.4 4e-06 27.0 0.3 2.9 3 0 0 3 3 3 1 Ankyrin repeat Ank_3 PF13606.6 ETO26681.1 - 8.4e-07 28.8 0.8 1.3e-05 25.2 0.1 3.4 3 0 0 3 3 3 1 Ankyrin repeat EMC3_TMCO1 PF01956.16 ETO26682.1 - 0.00033 20.4 0.9 0.00033 20.4 0.9 1.8 2 1 0 2 2 2 1 Integral membrane protein EMC3/TMCO1-like DUF2207 PF09972.9 ETO26682.1 - 0.0013 17.6 8.8 0.028 13.2 2.4 2.0 1 1 1 2 2 2 2 Predicted membrane protein (DUF2207) DUF5542 PF17696.1 ETO26682.1 - 0.01 15.9 0.7 0.022 14.9 0.7 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5542) Connexin PF00029.19 ETO26682.1 - 0.011 15.6 2.9 0.011 15.6 2.9 1.9 1 1 0 2 2 2 0 Connexin Piezo_RRas_bdg PF12166.8 ETO26682.1 - 0.034 13.4 5.3 0.03 13.6 3.5 1.7 1 1 1 2 2 2 0 Piezo non-specific cation channel, R-Ras-binding domain TMCO5 PF14992.6 ETO26682.1 - 0.041 13.5 5.4 0.028 14.0 3.5 1.6 2 0 0 2 2 2 0 TMCO5 family BatD PF13584.6 ETO26682.1 - 0.12 11.1 0.3 0.4 9.4 0.0 1.7 2 0 0 2 2 2 0 Oxygen tolerance Orf78 PF06024.12 ETO26682.1 - 0.23 11.8 0.0 0.23 11.8 0.0 2.7 2 1 0 2 2 1 0 Orf78 (ac78) DUF5113 PF17140.4 ETO26682.1 - 0.28 11.0 0.1 0.28 11.0 0.1 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) E1-E2_ATPase PF00122.20 ETO26682.1 - 0.34 10.4 0.9 0.51 9.8 0.0 1.7 2 0 0 2 2 2 0 E1-E2 ATPase DUF4834 PF16118.5 ETO26682.1 - 0.53 11.3 0.0 0.53 11.3 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4834) PS_Dcarbxylase PF02666.15 ETO26683.1 - 4.2e-44 150.5 0.0 5.3e-44 150.2 0.0 1.1 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase DUF45 PF01863.17 ETO26684.1 - 0.51 10.4 9.7 0.098 12.7 6.1 1.5 2 0 0 2 2 2 0 Protein of unknown function DUF45 PAP_assoc PF03828.19 ETO26686.1 - 3.2e-12 46.5 3.7 1.2e-11 44.7 3.7 2.0 1 0 0 1 1 1 1 Cid1 family poly A polymerase AA_permease_2 PF13520.6 ETO26686.1 - 0.037 12.9 2.5 0.057 12.2 2.5 1.2 1 0 0 1 1 1 0 Amino acid permease Macoilin PF09726.9 ETO26686.1 - 0.34 9.4 11.4 0.45 9.0 11.4 1.2 1 0 0 1 1 1 0 Macoilin family Pol_alpha_B_N PF08418.10 ETO26686.1 - 0.35 10.8 11.0 0.59 10.1 11.0 1.4 1 0 0 1 1 1 0 DNA polymerase alpha subunit B N-terminal ZapB PF06005.12 ETO26687.1 - 2.7 8.5 10.5 0.18 12.3 4.1 2.2 3 0 0 3 3 3 0 Cell division protein ZapB Tubulin PF00091.25 ETO26688.1 - 7.3e-34 117.7 0.0 8.1e-34 117.5 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 ETO26688.1 - 2.1e-06 28.0 0.0 2.7e-06 27.7 0.0 1.2 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain RPN5_C PF18098.1 ETO26689.1 - 0.028 14.5 0.2 0.065 13.4 0.2 1.6 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN5 C-terminal domain Zip PF02535.22 ETO26689.1 - 3.1 6.9 18.0 0.56 9.4 14.4 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter TPR_2 PF07719.17 ETO26692.1 - 1.2e-07 31.3 5.3 0.01 15.9 0.1 4.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26692.1 - 2.7e-07 30.1 7.5 0.0028 17.4 0.1 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26692.1 - 7.4e-06 25.8 5.1 0.0056 16.8 0.1 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26692.1 - 0.00022 21.5 6.2 2.6 8.4 0.1 3.8 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26692.1 - 0.0051 16.7 0.4 6.7 7.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO26692.1 - 0.038 14.2 3.0 0.62 10.3 0.5 3.3 3 0 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETO26692.1 - 0.078 13.1 0.0 0.31 11.2 0.0 2.1 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26692.1 - 0.11 12.2 5.3 1.9 8.2 0.4 3.5 2 1 2 4 4 4 0 TPR repeat TPR_14 PF13428.6 ETO26692.1 - 0.17 12.8 1.5 14 6.8 0.0 3.4 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26692.1 - 0.42 10.6 3.1 51 3.9 0.1 4.0 3 1 1 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26692.1 - 2.2 8.8 9.0 0.82 10.2 0.2 3.3 3 1 1 4 4 4 0 Tetratricopeptide repeat STI1 PF17830.1 ETO26692.1 - 3.9 7.5 8.8 20 5.2 1.8 3.7 2 1 1 3 3 3 0 STI1 domain NPL4 PF05021.15 ETO26693.1 - 2.8e-23 82.7 0.0 5.3e-23 81.8 0.0 1.4 1 0 0 1 1 1 1 NPL4 family UN_NPL4 PF11543.8 ETO26693.1 - 8.5e-11 42.2 0.0 4.6e-10 39.9 0.0 2.2 2 0 0 2 2 2 1 Nuclear pore localisation protein NPL4 Ubiquitin_2 PF14560.6 ETO26693.1 - 0.0029 18.0 0.0 0.013 16.0 0.0 2.0 2 0 0 2 2 2 1 Ubiquitin-like domain zf-NPL4 PF05020.15 ETO26693.1 - 0.011 15.8 0.3 0.036 14.2 0.2 1.8 1 1 0 1 1 1 0 NPL4 family, putative zinc binding region ubiquitin PF00240.23 ETO26693.1 - 0.018 14.8 0.1 0.24 11.2 0.0 2.5 2 0 0 2 2 2 0 Ubiquitin family BNIP3 PF06553.12 ETO26693.1 - 0.084 12.5 1.2 0.14 11.8 1.2 1.3 1 0 0 1 1 1 0 BNIP3 AMP-binding_C_2 PF14535.6 ETO26693.1 - 0.13 12.6 0.0 3.4 8.0 0.0 2.4 2 0 0 2 2 2 0 AMP-binding enzyme C-terminal domain Pkinase PF00069.25 ETO26695.1 - 2.8e-13 49.9 0.4 5.7e-13 48.8 0.4 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26695.1 - 0.00015 21.2 0.2 0.00031 20.1 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Ion_trans PF00520.31 ETO26696.1 - 1.6e-17 63.6 18.0 1.6e-17 63.6 18.0 1.7 2 0 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 ETO26696.1 - 7.9e-07 28.1 12.1 1.4e-06 27.3 12.1 1.4 1 0 0 1 1 1 1 Polycystin cation channel Pkinase PF00069.25 ETO26697.1 - 1.7e-38 132.5 0.0 1.9e-38 132.3 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26697.1 - 2.1e-20 73.1 0.0 2.6e-20 72.8 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO26697.1 - 0.022 13.6 0.0 0.029 13.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Kinase-like PF14531.6 ETO26697.1 - 0.089 12.1 0.0 0.11 11.8 0.0 1.1 1 0 0 1 1 1 0 Kinase-like Androgen_recep PF02166.16 ETO26698.1 - 0.058 12.2 4.4 0.095 11.5 4.4 1.3 1 0 0 1 1 1 0 Androgen receptor Neugrin PF06413.11 ETO26698.1 - 1.6 8.7 6.3 0.22 11.5 1.0 2.2 3 0 0 3 3 3 0 Neugrin Glycos_transf_1 PF00534.20 ETO26699.1 - 2e-13 50.2 0.0 3.9e-13 49.3 0.0 1.5 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO26699.1 - 2.1e-07 31.4 0.0 4e-07 30.5 0.0 1.4 1 0 0 1 1 1 1 Glycosyl transferases group 1 SpoIIIAH PF12685.7 ETO26700.1 - 1.2 8.9 10.0 8.7 6.1 0.2 2.2 2 0 0 2 2 2 0 SpoIIIAH-like protein TPR_12 PF13424.6 ETO26702.1 - 5.9e-82 270.0 23.1 4.1e-17 62.2 0.0 9.3 5 2 2 9 9 9 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26702.1 - 2.2e-50 166.5 47.0 0.00019 21.1 0.0 14.6 14 2 0 14 14 14 11 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26702.1 - 2.4e-42 139.6 45.5 0.0024 17.9 0.9 13.8 14 0 0 14 14 13 13 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26702.1 - 4e-38 128.2 15.8 0.00015 21.5 0.1 12.2 13 0 0 13 13 13 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO26702.1 - 9.2e-32 106.7 26.5 0.0045 16.9 0.4 13.8 14 0 0 14 14 13 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26702.1 - 3.8e-25 86.0 42.7 0.0027 17.8 1.1 14.9 16 0 0 16 16 14 8 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26702.1 - 2.5e-17 62.3 16.0 0.016 15.8 0.0 12.2 13 0 0 13 13 13 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26702.1 - 8.5e-13 48.0 13.3 0.96 10.4 0.0 10.6 10 2 1 12 12 11 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO26702.1 - 6.2e-09 35.7 13.8 0.047 13.1 0.0 5.0 2 1 2 5 5 5 4 MalT-like TPR region TPR_16 PF13432.6 ETO26702.1 - 9.6e-09 35.8 13.7 1.1 10.0 0.0 9.0 9 3 0 9 9 8 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26702.1 - 9.7e-09 35.0 8.1 15 6.3 0.0 9.7 10 0 0 10 10 9 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO26702.1 - 2.7e-06 27.4 10.5 0.068 13.3 0.0 6.0 5 1 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26702.1 - 3.2e-06 27.6 13.7 0.99 10.0 0.0 7.8 7 2 1 9 9 9 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26702.1 - 0.00051 19.7 23.2 12 5.7 0.1 11.4 10 3 1 11 11 11 0 TPR repeat Ank_5 PF13857.6 ETO26702.1 - 0.038 14.3 0.0 0.038 14.3 0.0 3.1 3 0 0 3 3 2 0 Ankyrin repeats (many copies) Vta1_C PF18097.1 ETO26702.1 - 0.11 12.3 0.7 0.52 10.0 0.3 2.5 2 0 0 2 2 2 0 Vta1 C-terminal domain Atrophin-1 PF03154.15 ETO26702.1 - 0.89 7.8 6.8 1.4 7.1 6.8 1.2 1 0 0 1 1 1 0 Atrophin-1 family Sel1 PF08238.12 ETO26702.1 - 5.2 7.9 14.2 15 6.5 0.1 5.3 5 0 0 5 5 5 0 Sel1 repeat Fis1_TPR_C PF14853.6 ETO26702.1 - 5.4 7.2 11.8 1.9 8.6 1.3 3.6 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat Endonuclease_5 PF04493.14 ETO26703.1 - 3e-07 30.3 0.0 4.6e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Endonuclease V Acatn PF13000.7 ETO26703.1 - 0.001 17.7 1.8 0.0014 17.2 1.8 1.1 1 0 0 1 1 1 1 Acetyl-coenzyme A transporter 1 TMEM208_SND2 PF05620.11 ETO26703.1 - 0.046 13.5 0.4 0.084 12.6 0.4 1.4 1 0 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 DUF92 PF01940.16 ETO26703.1 - 0.053 12.9 0.0 0.056 12.9 0.0 1.2 1 0 0 1 1 1 0 Integral membrane protein DUF92 Ni_hydr_CYTB PF01292.20 ETO26703.1 - 0.1 12.2 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 SecY PF00344.20 ETO26704.1 - 0.28 10.4 0.5 0.4 9.9 0.5 1.2 1 0 0 1 1 1 0 SecY translocase DUF3073 PF11273.8 ETO26704.1 - 1.1 10.0 5.3 0.24 12.2 1.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3073) Secretin_N_2 PF07655.13 ETO26705.1 - 2.9 8.5 10.3 0.11 13.0 4.2 1.7 2 0 0 2 2 2 0 Secretin N-terminal domain Pkinase PF00069.25 ETO26706.1 - 0.00053 19.4 0.0 0.00076 18.9 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain YiiD_C PF09500.10 ETO26707.1 - 0.079 12.8 1.2 0.48 10.2 0.1 2.0 2 0 0 2 2 2 0 Putative thioesterase (yiiD_Cterm) 7tm_1 PF00001.21 ETO26707.1 - 0.17 11.2 0.3 0.25 10.6 0.3 1.3 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Orf78 PF06024.12 ETO26707.1 - 6.4 7.1 8.7 1.1 9.7 1.0 2.0 2 0 0 2 2 2 0 Orf78 (ac78) G-alpha PF00503.20 ETO26708.1 - 3.1e-31 108.8 4.2 3.2e-28 98.9 0.2 2.5 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO26708.1 - 0.0013 18.3 0.3 0.0035 16.8 0.3 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family TFIIA PF03153.13 ETO26708.1 - 1.5 8.7 33.5 0.013 15.6 21.0 2.3 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit CDC45 PF02724.14 ETO26709.1 - 0.15 10.4 22.9 0.16 10.2 22.9 1.1 1 0 0 1 1 1 0 CDC45-like protein AC_N PF16214.5 ETO26709.1 - 0.82 8.7 7.5 0.95 8.5 7.5 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region PRKCSH-like PF12999.7 ETO26709.1 - 2.2 8.1 7.8 4.1 7.2 7.8 1.4 1 0 0 1 1 1 0 Glucosidase II beta subunit-like SRP-alpha_N PF04086.13 ETO26709.1 - 6.9 6.5 23.6 9.3 6.1 23.6 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal LAP1C PF05609.12 ETO26709.1 - 9.8 5.1 19.8 12 4.9 19.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CR6_interact PF10147.9 ETO26710.1 - 0.03 14.0 12.6 0.044 13.5 12.6 1.3 1 1 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 Transket_pyr PF02779.24 ETO26711.1 - 8.8e-29 100.4 0.0 1.1e-28 100.2 0.0 1.1 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain UPF0060 PF02694.15 ETO26711.1 - 0.068 13.4 0.1 0.098 12.9 0.1 1.3 1 0 0 1 1 1 0 Uncharacterised BCR, YnfA/UPF0060 family Plasmodium_Vir PF05795.11 ETO26711.1 - 0.52 9.7 2.2 0.7 9.2 2.2 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein MatE PF01554.18 ETO26713.1 - 1.7e-25 89.5 6.3 1.7e-25 89.5 6.3 3.0 3 0 0 3 3 3 1 MatE Polysacc_synt_C PF14667.6 ETO26713.1 - 0.0016 18.5 5.7 0.0016 18.5 5.7 3.1 3 1 0 3 3 3 1 Polysaccharide biosynthesis C-terminal domain RNA_pol_Rpc4 PF05132.14 ETO26713.1 - 0.019 15.4 0.0 0.027 14.9 0.0 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 Tim54 PF11711.8 ETO26713.1 - 0.031 13.1 0.0 0.038 12.8 0.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 TRAP_alpha PF03896.16 ETO26713.1 - 0.4 9.8 5.7 0.65 9.1 5.7 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CPSF100_C PF13299.6 ETO26713.1 - 0.41 10.8 5.2 0.58 10.3 5.2 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3408 PF11888.8 ETO26713.1 - 0.67 10.1 7.4 1.1 9.4 7.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) PI3K_1B_p101 PF10486.9 ETO26713.1 - 0.86 7.3 2.3 1.1 6.9 2.3 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sporozoite_P67 PF05642.11 ETO26713.1 - 1.1 7.2 8.9 1.5 6.8 8.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Afi1 PF07792.12 ETO26713.1 - 3 8.3 6.8 4.9 7.6 6.8 1.2 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM176 PF14851.6 ETO26713.1 - 3.3 7.4 9.7 6.6 6.4 9.7 1.5 1 0 0 1 1 1 0 FAM176 family DUF4746 PF15928.5 ETO26713.1 - 3.5 7.0 9.1 5.9 6.2 9.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop14 PF04147.12 ETO26713.1 - 5 5.2 14.2 6.7 4.8 14.2 1.1 1 0 0 1 1 1 0 Nop14-like family TFIIF_alpha PF05793.12 ETO26713.1 - 7.1 5.1 15.8 9.3 4.7 15.8 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TFIIA PF03153.13 ETO26714.1 - 5.8 6.8 19.3 6.9 6.5 19.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SH3_1 PF00018.28 ETO26715.1 - 3.2e-12 45.9 0.2 5.4e-12 45.1 0.2 1.4 1 0 0 1 1 1 1 SH3 domain SH3_9 PF14604.6 ETO26715.1 - 2.7e-11 43.1 0.3 4.4e-11 42.5 0.3 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETO26715.1 - 4.4e-05 23.1 0.0 8.4e-05 22.2 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_4 PF06347.13 ETO26715.1 - 0.0016 18.2 0.1 0.0029 17.4 0.1 1.4 1 0 0 1 1 1 1 Bacterial SH3 domain SH3_3 PF08239.11 ETO26715.1 - 0.02 15.2 0.5 0.034 14.4 0.5 1.4 1 0 0 1 1 1 0 Bacterial SH3 domain Pes-10 PF07149.11 ETO26715.1 - 0.031 13.4 4.3 0.039 13.0 4.3 1.0 1 0 0 1 1 1 0 Pes-10 Clathrin_lg_ch PF01086.17 ETO26716.1 - 2.3e-17 63.8 21.9 4.8e-17 62.8 21.9 1.5 1 1 0 1 1 1 1 Clathrin light chain FemAB PF02388.16 ETO26716.1 - 0.0046 15.9 5.5 0.0058 15.5 5.5 1.1 1 0 0 1 1 1 1 FemAB family DUF1389 PF07146.11 ETO26716.1 - 0.0055 16.0 3.8 0.0074 15.6 3.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1389) MTP18 PF10558.9 ETO26716.1 - 0.057 13.4 0.5 0.086 12.8 0.5 1.2 1 0 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) Auts2 PF15336.6 ETO26716.1 - 0.35 11.0 4.2 0.53 10.4 4.2 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein PTPlike_phytase PF14566.6 ETO26716.1 - 1.6 8.8 7.1 0.52 10.4 4.5 1.6 2 0 0 2 2 2 0 Inositol hexakisphosphate DUF4407 PF14362.6 ETO26716.1 - 2 7.7 6.7 2.1 7.6 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4337 PF14235.6 ETO26716.1 - 2.7 8.1 8.4 4.2 7.4 8.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) DUF725 PF05267.12 ETO26718.1 - 0.0022 17.9 3.0 0.0022 17.9 3.0 3.6 2 2 0 2 2 2 1 Protein of unknown function (DUF725) Apolipoprotein PF01442.18 ETO26718.1 - 0.0049 16.8 7.0 0.0049 16.8 7.0 3.1 1 1 2 3 3 3 1 Apolipoprotein A1/A4/E domain MCPsignal PF00015.21 ETO26718.1 - 0.011 15.5 15.0 2 8.2 1.7 3.9 2 1 2 4 4 4 0 Methyl-accepting chemotaxis protein (MCP) signalling domain SHE3 PF17078.5 ETO26718.1 - 0.03 14.0 43.6 0.09 12.5 17.3 3.3 1 1 2 3 3 3 0 SWI5-dependent HO expression protein 3 Vac_Fusion PF02346.16 ETO26718.1 - 0.035 13.7 8.8 3 7.5 0.1 4.5 4 0 0 4 4 4 0 Chordopoxvirus multifunctional envelope protein A27 5_3_exonuc PF01367.20 ETO26718.1 - 0.062 13.9 0.5 0.062 13.9 0.5 3.7 1 1 2 3 3 2 0 5'-3' exonuclease, C-terminal SAM fold DUF1664 PF07889.12 ETO26718.1 - 0.43 10.6 29.9 0.34 11.0 1.0 4.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) KxDL PF10241.9 ETO26718.1 - 1.1 9.6 32.0 1.1 9.6 3.8 4.5 3 1 1 4 4 4 0 Uncharacterized conserved protein DUF948 PF06103.11 ETO26718.1 - 1.2 9.4 21.2 6.2 7.1 0.2 4.8 1 1 4 5 5 5 0 Bacterial protein of unknown function (DUF948) FtsK_SpoIIIE PF01580.18 ETO26718.1 - 1.8 7.9 8.6 1.4 8.2 0.8 2.5 1 1 2 3 3 3 0 FtsK/SpoIIIE family Nup54 PF13874.6 ETO26718.1 - 2 8.5 28.2 0.45 10.6 4.0 4.3 1 1 2 3 3 2 0 Nucleoporin complex subunit 54 Baculo_PEP_C PF04513.12 ETO26718.1 - 2.8 8.0 24.4 5.5 7.0 0.7 4.1 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus SF-assemblin PF06705.11 ETO26718.1 - 2.8 7.2 38.8 3.7 6.8 14.5 3.3 1 1 2 3 3 3 0 SF-assemblin/beta giardin Clathrin_propel PF01394.20 ETO26719.1 - 0.06 13.7 0.1 0.19 12.1 0.0 1.9 2 0 0 2 2 2 0 Clathrin propeller repeat DUF3391 PF11871.8 ETO26719.1 - 0.14 12.7 0.5 0.14 12.7 0.5 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF3391) RPEL PF02755.15 ETO26720.1 - 0.018 14.7 3.8 0.11 12.3 0.4 3.7 4 0 0 4 4 4 0 RPEL repeat Phage_holin_7_1 PF16081.5 ETO26720.1 - 0.19 11.9 0.2 0.47 10.6 0.2 1.7 1 0 0 1 1 1 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Terminase_2 PF03592.16 ETO26720.1 - 9.6 6.7 15.2 3.8 8.0 8.4 3.1 2 1 1 3 3 3 0 Terminase small subunit Sfi1 PF08457.10 ETO26721.1 - 0.0035 15.9 0.6 0.0053 15.3 0.6 1.2 1 0 0 1 1 1 1 Sfi1 spindle body protein Cys_rich_VLP PF14194.6 ETO26721.1 - 0.017 15.2 2.1 0.019 15.1 0.2 1.9 2 0 0 2 2 2 0 Cysteine-rich VLP DUF1929 PF09118.11 ETO26723.1 - 1.5e-07 31.6 0.1 3.6e-07 30.4 0.1 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF1929) Kelch_2 PF07646.15 ETO26723.1 - 0.00048 20.0 0.0 0.99 9.5 0.0 5.0 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.6 ETO26723.1 - 0.00075 19.7 0.6 1.6 9.2 0.0 5.0 6 0 0 6 6 6 1 Kelch motif Glyoxal_oxid_N PF07250.11 ETO26723.1 - 0.0016 17.7 0.2 10 5.2 0.0 3.9 3 1 0 3 3 3 2 Glyoxal oxidase N-terminus WD40 PF00400.32 ETO26724.1 - 9.3e-60 197.2 21.4 1.1e-08 35.5 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26724.1 - 5.2e-24 84.4 2.2 3.5e-05 24.0 0.0 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26724.1 - 6.8e-15 54.9 3.2 2.1e-05 23.6 0.0 6.0 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO26724.1 - 1e-07 31.6 2.3 0.072 12.4 0.0 3.8 2 1 2 4 4 4 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO26724.1 - 1.2e-07 30.6 1.3 0.0028 16.3 0.1 2.7 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO26724.1 - 1.2e-05 25.1 0.2 0.0014 18.3 0.2 3.1 1 1 0 1 1 1 1 PQQ-like domain PD40 PF07676.12 ETO26724.1 - 3.4e-05 23.7 5.9 4.4 7.4 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO26724.1 - 4.8e-05 22.8 1.4 0.12 11.7 0.0 3.6 1 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO26724.1 - 0.00012 20.9 5.2 0.5 8.9 0.0 4.3 1 1 3 4 4 4 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO26724.1 - 0.0015 18.3 0.0 1.5 8.9 0.0 4.6 5 0 0 5 5 5 1 PQQ enzyme repeat Me-amine-dh_H PF06433.11 ETO26724.1 - 0.0058 15.5 0.2 2.2 7.0 0.0 3.2 2 1 0 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) DUF1513 PF07433.11 ETO26724.1 - 0.0073 15.4 0.1 8.5 5.4 0.0 3.4 2 2 1 4 4 4 1 Protein of unknown function (DUF1513) Pectate_lyase22 PF14583.6 ETO26724.1 - 0.019 13.6 0.0 0.063 11.9 0.0 1.9 2 0 0 2 2 2 0 Oligogalacturonate lyase Nucleoporin_N PF08801.11 ETO26724.1 - 0.036 12.8 4.6 2.5 6.8 1.4 3.6 1 1 1 3 3 3 0 Nup133 N terminal like nos_propeller PF18764.1 ETO26724.1 - 0.1 12.5 0.6 7.7 6.5 0.1 3.4 2 1 1 3 3 3 0 Nitrous oxide reductase propeller repeat Str_synth PF03088.16 ETO26724.1 - 0.11 12.7 0.0 29 4.9 0.0 3.6 3 1 0 3 3 3 0 Strictosidine synthase AzlD PF05437.12 ETO26725.1 - 0.12 12.5 5.3 0.038 14.1 2.0 1.8 2 0 0 2 2 2 0 Branched-chain amino acid transport protein (AzlD) APG6_N PF17675.1 ETO26726.1 - 0.025 15.1 2.6 0.025 15.1 2.6 4.9 2 1 3 5 5 5 0 Apg6 coiled-coil region DUF4530 PF15039.6 ETO26726.1 - 0.042 14.0 2.8 0.64 10.2 0.4 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4530) LPP PF04728.13 ETO26726.1 - 0.11 12.9 8.9 0.45 11.0 0.1 4.6 3 1 0 3 3 3 0 Lipoprotein leucine-zipper FlaC_arch PF05377.11 ETO26726.1 - 4.3 7.8 26.6 2.4 8.6 0.9 7.0 4 3 2 6 6 6 0 Flagella accessory protein C (FlaC) HSBP1 PF06825.12 ETO26726.1 - 5.8 6.9 11.0 0.39 10.6 0.8 3.1 3 0 0 3 3 3 0 Heat shock factor binding protein 1 SAM_1 PF00536.30 ETO26727.1 - 4.3e-19 68.7 0.2 4.1e-08 33.6 0.1 2.4 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO26727.1 - 4.2e-12 46.0 0.1 8.6e-06 25.8 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO26727.1 - 0.00023 21.1 0.3 0.00089 19.2 0.1 2.0 2 0 0 2 2 2 1 Sterile alpha motif (SAM)/Pointed domain WD40 PF00400.32 ETO26728.1 - 5.8e-31 106.1 19.0 4e-07 30.6 1.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26728.1 - 9.2e-10 38.7 5.3 0.019 15.2 0.0 5.5 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO26728.1 - 2.1e-05 23.4 6.4 0.12 11.0 0.9 4.4 2 2 2 4 4 4 4 Nucleoporin Nup120/160 PAP_assoc PF03828.19 ETO26729.1 - 5.8e-11 42.4 0.7 6.9e-07 29.4 0.2 4.0 3 0 0 3 3 3 2 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETO26729.1 - 1.6e-05 25.1 0.1 5.6e-05 23.4 0.0 1.9 2 1 0 2 2 2 1 Nucleotidyltransferase domain YajC PF02699.15 ETO26729.1 - 0.14 12.1 1.5 0.29 11.1 1.5 1.5 1 0 0 1 1 1 0 Preprotein translocase subunit EphA2_TM PF14575.6 ETO26729.1 - 1.4 9.8 0.0 1.4 9.8 0.0 2.6 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain Menin PF05053.13 ETO26729.1 - 6.1 5.1 15.8 10 4.3 15.8 1.3 1 0 0 1 1 1 0 Menin Pkinase PF00069.25 ETO26730.1 - 1e-39 136.5 0.0 8.1e-35 120.5 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26730.1 - 5.1e-24 84.9 0.0 2.3e-22 79.6 0.1 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO26730.1 - 0.0036 16.7 0.0 0.13 11.5 0.0 2.4 2 0 0 2 2 2 1 Kinase-like APH PF01636.23 ETO26730.1 - 0.0053 16.7 0.0 0.014 15.4 0.0 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO26730.1 - 0.015 14.6 1.5 0.029 13.7 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PhoLip_ATPase_C PF16212.5 ETO26732.1 - 1.4e-58 198.6 26.7 1.4e-58 198.6 26.7 3.5 4 0 0 4 4 4 1 Phospholipid-translocating P-type ATPase C-terminal PhoLip_ATPase_N PF16209.5 ETO26732.1 - 3.5e-18 65.1 6.8 9.9e-10 38.0 0.8 3.1 1 1 1 2 2 2 2 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 ETO26732.1 - 5.6e-11 42.3 0.1 5.6e-11 42.3 0.1 3.0 4 1 0 4 4 4 1 E1-E2 ATPase Cation_ATPase PF13246.6 ETO26732.1 - 6.5e-10 39.0 0.0 2.3e-09 37.2 0.0 1.9 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO26732.1 - 0.00087 19.6 0.1 3 8.1 0.0 3.2 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase Cwf_Cwc_15 PF04889.12 ETO26732.1 - 1.1 8.9 16.0 0.035 13.8 5.7 2.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein FAM176 PF14851.6 ETO26732.1 - 1.3 8.7 4.1 0.89 9.2 0.1 2.6 2 0 0 2 2 2 0 FAM176 family DUF4834 PF16118.5 ETO26733.1 - 0.0015 19.4 0.8 0.0027 18.6 0.8 1.4 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) RCR PF12273.8 ETO26733.1 - 0.0062 17.2 0.1 0.011 16.4 0.1 1.4 1 0 0 1 1 1 1 Chitin synthesis regulation, resistance to Congo red DUF3552 PF12072.8 ETO26733.1 - 0.0085 15.5 0.2 0.01 15.2 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3552) EphA2_TM PF14575.6 ETO26733.1 - 0.0087 16.9 0.9 0.014 16.3 0.9 1.4 1 1 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Peptidase_S49_N PF08496.10 ETO26733.1 - 0.0088 16.1 0.2 0.011 15.8 0.2 1.1 1 0 0 1 1 1 1 Peptidase family S49 N-terminal ECSCR PF15820.5 ETO26733.1 - 0.01 15.6 0.0 0.015 15.1 0.0 1.2 1 0 0 1 1 1 0 Endothelial cell-specific chemotaxis regulator Pilin_N PF07790.11 ETO26733.1 - 0.012 16.5 0.1 0.017 16.0 0.1 1.3 1 0 0 1 1 1 0 Archaeal Type IV pilin, N-terminal DUF3139 PF11337.8 ETO26733.1 - 0.02 15.6 0.2 0.036 14.7 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3139) DUF4083 PF13314.6 ETO26733.1 - 0.024 14.6 1.2 0.028 14.4 0.1 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4083) OSTbeta PF15048.6 ETO26733.1 - 0.029 14.5 0.1 0.037 14.2 0.1 1.2 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein SARAF PF06682.12 ETO26733.1 - 0.045 13.4 0.1 0.055 13.1 0.1 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis MFS_Mycoplasma PF07672.13 ETO26733.1 - 0.046 13.0 0.1 0.058 12.7 0.1 1.1 1 0 0 1 1 1 0 Mycoplasma MFS transporter SeqA PF03925.13 ETO26733.1 - 0.05 13.6 0.1 0.07 13.1 0.1 1.2 1 0 0 1 1 1 0 SeqA protein C-terminal domain DUF4330 PF14221.6 ETO26733.1 - 0.061 13.5 0.9 0.087 13.0 0.9 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) DUF929 PF06053.11 ETO26733.1 - 0.076 12.3 0.0 0.095 12.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF929) Shisa PF13908.6 ETO26733.1 - 0.12 12.6 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 ETO26733.1 - 0.12 12.2 1.0 0.33 10.9 0.8 1.9 2 1 0 2 2 2 0 TMEM154 protein family V_ATPase_I PF01496.19 ETO26733.1 - 0.12 10.2 0.1 0.15 9.9 0.1 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 ETO26733.1 - 0.13 12.0 0.1 0.17 11.6 0.1 1.1 1 0 0 1 1 1 0 Connexin Phage_holin_3_6 PF07332.11 ETO26733.1 - 0.14 12.2 1.6 0.22 11.6 0.7 1.7 1 1 1 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Tetraspanin PF00335.20 ETO26733.1 - 0.16 11.7 0.0 0.19 11.4 0.0 1.1 1 0 0 1 1 1 0 Tetraspanin family DUF4381 PF14316.6 ETO26733.1 - 0.21 11.8 0.0 0.32 11.2 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) WBP-1 PF11669.8 ETO26733.1 - 1.4 9.6 4.2 11 6.7 4.2 2.1 1 1 0 1 1 1 0 WW domain-binding protein 1 DHHC PF01529.20 ETO26734.1 - 2.4 8.3 11.5 1.7 8.8 2.5 3.1 3 1 0 3 3 3 0 DHHC palmitoyltransferase WD40 PF00400.32 ETO26735.1 - 4.2e-62 204.6 19.7 6.6e-08 33.1 0.5 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26735.1 - 1.9e-16 60.1 3.5 0.0082 16.4 0.2 6.6 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26735.1 - 2.9e-13 49.5 1.1 0.32 9.9 0.0 7.3 1 1 7 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO26735.1 - 3e-08 32.8 15.3 2.8 6.5 0.0 7.6 3 2 3 8 8 8 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO26735.1 - 1.9e-06 27.5 0.0 1.9 7.8 0.0 3.9 2 2 3 5 5 5 3 WD40-like domain DUF2527 PF10736.9 ETO26735.1 - 0.00075 19.3 0.5 0.8 9.6 0.0 2.8 2 0 0 2 2 2 2 Protein of unknown function (DUF2627) Nucleoporin_N PF08801.11 ETO26735.1 - 0.00097 18.0 6.0 0.75 8.5 0.0 4.4 1 1 3 5 5 5 2 Nup133 N terminal like DUF5570 PF17731.1 ETO26735.1 - 0.032 14.3 4.9 6.1 7.0 0.1 4.6 3 2 3 6 6 6 0 Family of unknown function (DUF5570) Ubiquitin_3 PF14836.6 ETO26735.1 - 0.033 14.2 0.1 5.8 7.0 0.0 3.7 3 1 0 4 4 4 0 Ubiquitin-like domain Cytochrom_D1 PF02239.16 ETO26735.1 - 0.034 12.7 1.4 2.3 6.7 0.0 3.0 2 1 0 3 3 3 0 Cytochrome D1 heme domain Ricin_B_lectin PF00652.22 ETO26735.1 - 0.064 13.5 0.3 1.1 9.5 0.0 2.8 3 2 0 3 3 3 0 Ricin-type beta-trefoil lectin domain DUF3475 PF11961.8 ETO26735.1 - 0.08 13.0 0.4 7.9 6.6 0.0 4.0 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) Prok-JAB PF14464.6 ETO26735.1 - 0.11 12.3 0.5 4 7.2 0.2 3.0 2 1 0 2 2 2 0 Prokaryotic homologs of the JAB domain DUF5046 PF16465.5 ETO26735.1 - 0.14 11.6 0.0 43 3.4 0.0 3.3 1 1 2 4 4 4 0 Domain of unknown function (DUF5046) DUF4999 PF16390.5 ETO26735.1 - 0.17 12.1 0.7 66 3.8 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function Vac_Fusion PF02346.16 ETO26735.1 - 0.18 11.4 0.2 0.98 9.1 0.1 2.2 2 0 0 2 2 2 0 Chordopoxvirus multifunctional envelope protein A27 DUF3341 PF11821.8 ETO26736.1 - 0.24 11.1 3.1 0.16 11.6 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3341) Kelch_6 PF13964.6 ETO26737.1 - 0.0001 22.5 2.3 1.5 9.2 0.0 5.6 5 1 1 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO26737.1 - 0.00019 20.9 9.9 0.041 13.5 0.2 5.9 5 1 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO26737.1 - 0.046 13.7 0.6 47 4.1 0.0 4.0 4 0 0 4 4 4 0 Galactose oxidase, central domain NAPRTase_N PF17767.1 ETO26737.1 - 0.48 10.8 6.3 0.13 12.7 1.6 2.1 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain O-antigen_lig PF13425.6 ETO26737.1 - 5.6 5.6 8.9 1.6 7.4 1.4 2.4 2 0 0 2 2 2 0 O-antigen ligase like membrane protein SURF1 PF02104.15 ETO26738.1 - 0.044 14.0 0.0 0.057 13.7 0.0 1.2 1 0 0 1 1 1 0 SURF1 family EOS1 PF12326.8 ETO26738.1 - 0.1 12.5 0.0 0.11 12.4 0.0 1.1 1 0 0 1 1 1 0 N-glycosylation protein Pkinase PF00069.25 ETO26740.1 - 7.8e-67 225.4 0.0 1.3e-66 224.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26740.1 - 1.3e-30 106.6 0.0 2.3e-30 105.7 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 ETO26740.1 - 1.5e-17 63.8 11.1 2.1e-07 31.3 0.5 3.9 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO26740.1 - 3.8e-14 51.3 2.8 2.4e-05 23.9 0.0 4.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 ETO26740.1 - 7e-11 41.1 3.7 3.3e-06 26.3 0.2 3.9 3 0 0 3 3 3 2 EF hand EF-hand_1 PF00036.32 ETO26740.1 - 8.7e-11 40.6 17.9 2.5e-07 29.7 0.2 5.0 5 1 0 5 5 4 2 EF hand EF-hand_8 PF13833.6 ETO26740.1 - 2.7e-10 40.0 7.0 0.00055 19.7 0.6 4.0 2 2 2 4 4 4 4 EF-hand domain pair APH PF01636.23 ETO26740.1 - 1.9e-06 28.0 0.0 3.5e-05 23.9 0.0 2.1 1 1 1 2 2 2 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO26740.1 - 0.00077 19.1 0.5 0.00077 19.1 0.5 2.1 2 0 0 2 2 1 1 RIO1 family EF-hand_4 PF12763.7 ETO26740.1 - 0.002 18.0 0.6 0.47 10.4 0.0 2.9 3 0 0 3 3 2 1 Cytoskeletal-regulatory complex EF hand Choline_kinase PF01633.20 ETO26740.1 - 0.0053 16.4 0.1 0.024 14.2 0.1 2.0 1 1 0 1 1 1 1 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 ETO26740.1 - 0.0085 15.1 0.4 0.043 12.8 0.1 2.0 2 0 0 2 2 2 1 Poxvirus serine/threonine protein kinase DSHCT PF08148.12 ETO26740.1 - 0.099 12.3 0.0 0.33 10.6 0.0 1.9 1 0 0 1 1 1 0 DSHCT (NUC185) domain CDC45 PF02724.14 ETO26740.1 - 0.29 9.4 12.1 0.44 8.8 12.1 1.2 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO26740.1 - 0.61 9.9 10.7 1 9.2 10.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CPSF100_C PF13299.6 ETO26740.1 - 0.96 9.6 6.7 1.7 8.8 6.7 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RRN3 PF05327.11 ETO26740.1 - 1.2 7.5 6.7 1.9 7.0 6.7 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Auts2 PF15336.6 ETO26740.1 - 1.3 9.1 10.5 2.4 8.2 10.5 1.4 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein RNA_pol_Rpc4 PF05132.14 ETO26740.1 - 1.3 9.4 12.3 2.4 8.5 12.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 PTPRCAP PF15713.5 ETO26740.1 - 1.8 8.9 13.3 3.9 7.7 13.3 1.4 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF4554 PF15091.6 ETO26740.1 - 1.9 7.3 3.9 2.8 6.8 3.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) SpoIIP PF07454.11 ETO26740.1 - 2.3 7.6 9.9 3.7 6.9 9.9 1.2 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) DUF913 PF06025.12 ETO26740.1 - 2.4 7.1 4.3 4 6.3 4.3 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) FAM176 PF14851.6 ETO26740.1 - 3.6 7.2 10.1 7.1 6.3 10.1 1.5 1 0 0 1 1 1 0 FAM176 family Connexin PF00029.19 ETO26740.1 - 7.9 6.2 11.1 12 5.6 11.1 1.3 1 0 0 1 1 1 0 Connexin tRNA_anti-codon PF01336.25 ETO26742.1 - 8.2e-12 44.9 0.6 9.4e-07 28.7 0.1 2.9 2 1 0 2 2 2 2 OB-fold nucleic acid binding domain REPA_OB_2 PF16900.5 ETO26742.1 - 3.6e-10 39.6 3.1 2.8e-08 33.6 0.3 3.7 3 1 0 3 3 3 1 Replication protein A OB domain Rep-A_N PF04057.12 ETO26742.1 - 1.5e-05 24.9 0.2 7.4e-05 22.7 0.1 2.1 2 0 0 2 2 2 1 Replication factor-A protein 1, N-terminal domain CDC24_OB3 PF17244.2 ETO26742.1 - 0.0044 16.8 0.0 0.0081 15.9 0.0 1.5 1 0 0 1 1 1 1 Cell division control protein 24, OB domain 3 DUF223 PF02721.14 ETO26742.1 - 0.056 13.8 0.0 0.15 12.4 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF223 DUF4635 PF15466.6 ETO26742.1 - 0.068 12.7 0.2 0.16 11.5 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4635) Menin PF05053.13 ETO26744.1 - 0.041 12.3 14.1 0.049 12.0 14.1 1.1 1 0 0 1 1 1 0 Menin TPR_7 PF13176.6 ETO26744.1 - 0.11 12.6 0.1 0.25 11.5 0.1 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat SMC_N PF02463.19 ETO26745.1 - 1e-32 113.4 13.6 1.3e-28 99.9 0.0 3.6 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO26745.1 - 2.5e-10 41.2 38.3 3.7e-06 27.6 38.3 3.2 1 1 0 1 1 1 1 AAA domain AAA_21 PF13304.6 ETO26745.1 - 8.4e-06 25.8 0.1 8.4e-06 25.8 0.1 2.4 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETO26745.1 - 2.7e-05 23.8 0.0 6.7e-05 22.5 0.0 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO26745.1 - 0.062 13.8 0.2 0.062 13.8 0.2 3.0 2 2 0 2 2 2 0 ABC transporter RACo_C_ter PF14574.6 ETO26745.1 - 0.073 12.1 0.1 0.073 12.1 0.1 2.0 2 0 0 2 2 2 0 C-terminal domain of RACo the ASKHA domain DUF4407 PF14362.6 ETO26745.1 - 0.66 9.3 11.9 1.2 8.4 11.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) AAA_15 PF13175.6 ETO26745.1 - 1.3 8.7 37.8 52 3.4 37.8 2.7 1 1 0 1 1 1 0 AAA ATPase domain Golgin_A5 PF09787.9 ETO26745.1 - 2.4 7.6 32.7 11 5.3 29.6 2.8 2 1 1 3 3 3 0 Golgin subfamily A member 5 DUF5339 PF17274.2 ETO26745.1 - 4.7 8.1 14.6 0.079 13.8 2.8 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5339) SMC_N PF02463.19 ETO26746.1 - 5.3e-23 81.6 16.7 5.3e-23 81.6 16.7 2.2 2 1 0 2 2 2 1 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ETO26746.1 - 3e-21 75.9 0.7 8.7e-21 74.4 0.7 1.9 1 0 0 1 1 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ETO26746.1 - 9.5e-05 22.3 0.2 9.5e-05 22.3 0.2 2.3 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system Fez1 PF06818.15 ETO26746.1 - 0.0014 19.1 71.9 0.019 15.4 8.3 5.1 2 1 1 4 4 4 3 Fez1 Phage_lysis PF03245.13 ETO26746.1 - 0.0017 18.5 6.8 0.0017 18.5 6.8 4.9 3 2 1 4 4 4 1 Bacteriophage Rz lysis protein GAS PF13851.6 ETO26746.1 - 0.0057 16.0 16.1 0.0057 16.0 16.1 6.2 3 1 4 7 7 7 2 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 ETO26746.1 - 0.012 15.6 4.8 0.012 15.6 4.8 7.8 4 1 2 7 7 7 0 Designed helical repeat protein 10 domain ERM PF00769.19 ETO26746.1 - 0.24 11.2 75.5 0.19 11.5 33.9 3.5 2 1 1 3 3 3 0 Ezrin/radixin/moesin family AAA_13 PF13166.6 ETO26746.1 - 1.2 7.7 67.1 0.26 9.9 32.3 3.6 3 1 1 4 4 4 0 AAA domain DUF812 PF05667.11 ETO26746.1 - 4.3 6.1 83.8 0.0068 15.4 17.9 3.3 2 1 1 3 3 3 0 Protein of unknown function (DUF812) Spc7 PF08317.11 ETO26746.1 - 7.5 5.3 88.6 0.14 11.0 28.5 4.9 3 2 1 4 4 4 0 Spc7 kinetochore protein Lectin_N PF03954.14 ETO26747.1 - 0.0059 16.3 2.4 0.0059 16.3 2.4 2.2 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain ADIP PF11559.8 ETO26747.1 - 0.014 15.4 27.6 0.03 14.4 10.5 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding DUF5384 PF17358.2 ETO26747.1 - 0.021 14.9 4.9 0.021 14.9 4.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5384) GAS PF13851.6 ETO26747.1 - 0.035 13.5 25.2 0.064 12.6 12.5 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4530 PF15039.6 ETO26747.1 - 0.039 14.1 1.0 0.039 14.1 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4530) LT-IIB PF06453.11 ETO26747.1 - 0.065 13.1 0.1 0.49 10.3 0.1 2.1 2 0 0 2 2 2 0 Type II heat-labile enterotoxin , B subunit (LT-IIB) ZapB PF06005.12 ETO26747.1 - 0.13 12.8 27.9 1.1 9.7 9.3 2.8 2 1 1 3 3 3 0 Cell division protein ZapB DUF1664 PF07889.12 ETO26747.1 - 0.19 11.8 8.2 0.14 12.2 1.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) YabA PF06156.13 ETO26747.1 - 0.23 12.1 22.7 0.043 14.5 5.9 2.7 2 1 0 2 2 2 0 Initiation control protein YabA PIG-L PF02585.17 ETO26747.1 - 0.34 11.5 3.1 16 6.1 3.1 2.4 1 1 0 1 1 1 0 GlcNAc-PI de-N-acetylase ERM PF00769.19 ETO26747.1 - 0.34 10.7 21.8 0.62 9.8 8.8 2.2 2 0 0 2 2 2 0 Ezrin/radixin/moesin family HALZ PF02183.18 ETO26747.1 - 0.54 10.5 23.0 0.16 12.2 4.9 3.4 2 1 1 3 3 3 0 Homeobox associated leucine zipper Sec34 PF04136.15 ETO26747.1 - 0.6 10.0 14.8 1.5 8.7 3.1 2.2 2 0 0 2 2 2 0 Sec34-like family PCRF PF03462.18 ETO26747.1 - 2.5 7.9 16.2 1.4 8.7 4.9 2.1 1 1 0 2 2 2 0 PCRF domain DUF3450 PF11932.8 ETO26747.1 - 3.2 7.0 20.1 0.55 9.5 6.9 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) KASH_CCD PF14662.6 ETO26747.1 - 3.7 7.3 29.9 5.7 6.7 18.8 2.5 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH PEARLI-4 PF05278.12 ETO26747.1 - 4.6 6.7 16.2 0.51 9.9 8.5 2.1 2 0 0 2 2 2 0 Arabidopsis phospholipase-like protein (PEARLI 4) TMF_TATA_bd PF12325.8 ETO26747.1 - 8.6 6.6 27.0 0.41 10.9 5.2 3.2 1 1 2 3 3 3 0 TATA element modulatory factor 1 TATA binding Erf4 PF10256.9 ETO26748.1 - 0.076 13.1 1.3 0.43 10.7 0.3 2.5 2 1 0 2 2 2 0 Golgin subfamily A member 7/ERF4 family HycI PF01750.18 ETO26748.1 - 0.083 12.7 0.0 0.2 11.5 0.0 1.6 1 0 0 1 1 1 0 Hydrogenase maturation protease NLRC4_HD2 PF17776.1 ETO26749.1 - 0.00098 19.7 0.7 0.0014 19.2 0.7 1.1 1 0 0 1 1 1 1 NLRC4 helical domain HD2 BRCT PF00533.26 ETO26749.1 - 0.003 17.9 0.1 0.0051 17.2 0.1 1.4 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain EF-hand_7 PF13499.6 ETO26749.1 - 0.003 18.0 0.7 0.029 14.8 0.1 2.4 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO26749.1 - 0.02 14.8 0.0 0.059 13.3 0.0 1.8 1 0 0 1 1 1 0 EF-hand domain EF-hand_1 PF00036.32 ETO26749.1 - 0.025 14.1 0.1 0.079 12.6 0.1 1.9 1 0 0 1 1 1 0 EF hand YqaJ PF09588.10 ETO26749.1 - 0.072 13.2 0.2 0.19 11.9 0.1 1.7 2 0 0 2 2 2 0 YqaJ-like viral recombinase domain EF-hand_6 PF13405.6 ETO26750.1 - 0.018 14.9 0.2 0.065 13.2 0.2 2.0 1 0 0 1 1 1 0 EF-hand domain EF-hand_7 PF13499.6 ETO26750.1 - 0.038 14.5 0.3 0.43 11.1 0.1 3.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_8 PF13833.6 ETO26750.1 - 0.067 13.0 0.2 0.23 11.3 0.2 1.9 1 0 0 1 1 1 0 EF-hand domain pair DUF3335 PF11814.8 ETO26751.1 - 0.078 12.4 0.3 0.1 12.1 0.3 1.3 1 0 0 1 1 1 0 Peptidase_C39 like family FAD_binding_3 PF01494.19 ETO26752.1 - 1.2e-05 24.7 0.1 1.8e-05 24.1 0.1 1.3 1 0 0 1 1 1 1 FAD binding domain DUF4312 PF14189.6 ETO26752.1 - 0.044 13.8 0.8 0.27 11.2 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4312) DUF3348 PF11828.8 ETO26752.1 - 0.045 13.4 0.2 0.1 12.3 0.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3348) TRM13 PF05206.14 ETO26753.1 - 7.9e-26 91.1 6.2 7.9e-26 91.1 6.2 2.6 1 1 2 3 3 3 2 Methyltransferase TRM13 Glyco_hydro_47 PF01532.20 ETO26755.1 - 5e-54 183.9 9.1 1.9e-53 182.0 9.1 1.7 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 RE_HindIII PF09518.10 ETO26756.1 - 0.027 13.7 0.0 0.037 13.2 0.0 1.1 1 0 0 1 1 1 0 HindIII restriction endonuclease Dicty_REP PF05086.12 ETO26757.1 - 0.0023 16.0 9.9 0.0023 16.0 9.9 1.5 2 0 0 2 2 2 1 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 ETO26757.1 - 0.19 9.8 9.5 0.31 9.1 9.5 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Trypan_PARP PF05887.11 ETO26757.1 - 0.33 10.9 6.2 0.33 10.9 4.4 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF3439 PF11921.8 ETO26757.1 - 1.1 9.2 10.4 0.55 10.2 7.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Vasculin PF15337.6 ETO26759.1 - 0.077 13.8 2.4 0.23 12.3 0.2 2.4 1 1 1 2 2 2 0 Vascular protein family Vasculin-like 1 RuvC PF02075.17 ETO26761.1 - 0.041 13.8 0.7 2.3 8.1 0.0 2.9 3 0 0 3 3 3 0 Crossover junction endodeoxyribonuclease RuvC Presenilin PF01080.17 ETO26761.1 - 1.4 7.6 22.3 2.8 6.6 22.3 1.6 1 0 0 1 1 1 0 Presenilin DUF5600 PF18150.1 ETO26762.1 - 2.2e-18 66.8 0.4 6.2e-18 65.3 0.0 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF5600) EF-hand_4 PF12763.7 ETO26762.1 - 4.8e-09 36.1 1.1 4.8e-07 29.7 0.2 3.1 3 0 0 3 3 3 2 Cytoskeletal-regulatory complex EF hand DUF3491 PF11996.8 ETO26763.1 - 0.06 11.1 0.0 0.071 10.9 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3491) SPX PF03105.19 ETO26764.1 - 0.21 11.5 9.0 0.27 11.1 9.0 1.1 1 0 0 1 1 1 0 SPX domain Peptidase_S49_N PF08496.10 ETO26764.1 - 0.59 10.2 4.5 0.18 11.9 0.6 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal HORMA PF02301.18 ETO26765.1 - 0.017 14.8 0.7 0.025 14.2 0.7 1.2 1 0 0 1 1 1 0 HORMA domain zf-CCCH_4 PF18044.1 ETO26765.1 - 0.041 13.7 0.8 0.087 12.7 0.8 1.6 1 0 0 1 1 1 0 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETO26765.1 - 0.066 13.3 1.9 0.14 12.3 1.9 1.6 1 0 0 1 1 1 0 Zinc finger domain Bcr-Abl_Oligo PF09036.10 ETO26766.1 - 1.4 9.0 7.3 0.41 10.7 0.3 2.6 2 1 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain Ribonuc_red_lgC PF02867.15 ETO26767.1 - 2.8e-149 498.0 0.1 8.7e-108 361.1 0.0 3.3 3 1 0 3 3 3 3 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ETO26767.1 - 5.1e-24 84.1 0.0 1.1e-23 83.0 0.0 1.6 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 ETO26767.1 - 5.8e-13 49.2 0.0 1.8e-12 47.7 0.0 1.9 1 0 0 1 1 1 1 ATP cone domain Rad60-SLD PF11976.8 ETO26768.1 - 7e-24 83.4 0.1 8.7e-24 83.2 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETO26768.1 - 1.1e-11 44.3 0.1 1.4e-11 43.9 0.1 1.1 1 0 0 1 1 1 1 Ubiquitin family Pap_E4 PF02711.14 ETO26768.1 - 0.11 13.5 0.1 0.17 12.8 0.1 1.3 1 0 0 1 1 1 0 E4 protein Sec31 PF11549.8 ETO26768.1 - 0.17 11.8 5.1 0.19 11.7 3.9 1.7 1 1 0 1 1 1 0 Protein transport protein SEC31 ELFV_dehydrog PF00208.21 ETO26769.1 - 3.1e-53 181.0 0.1 4e-53 180.6 0.1 1.1 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ETO26769.1 - 5.3e-33 113.7 0.0 1e-32 112.7 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain 2-Hacid_dh_C PF02826.19 ETO26769.1 - 0.012 15.0 0.1 0.02 14.3 0.1 1.2 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ETO26769.1 - 0.027 14.9 0.1 0.049 14.1 0.1 1.5 1 0 0 1 1 1 0 Putative NAD(P)-binding Semialdhyde_dh PF01118.24 ETO26769.1 - 0.064 13.7 0.0 3.4 8.1 0.0 2.2 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain Androgen_recep PF02166.16 ETO26770.1 - 0.00013 21.0 2.4 0.00018 20.5 2.4 1.4 1 0 0 1 1 1 1 Androgen receptor BAF1_ABF1 PF04684.13 ETO26770.1 - 5.6 5.9 28.4 0.62 9.1 23.3 1.8 1 1 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor OATP PF03137.20 ETO26770.1 - 7.1 4.8 5.1 12 4.0 0.4 2.2 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family PKD_channel PF08016.12 ETO26771.1 - 0.0062 15.3 0.3 0.011 14.5 0.3 1.3 1 0 0 1 1 1 1 Polycystin cation channel KIP1 PF07765.12 ETO26773.1 - 0.025 14.7 1.9 0.35 11.0 2.1 2.1 2 0 0 2 2 2 0 KIP1-like protein TERB2 PF15101.6 ETO26773.1 - 0.054 13.6 0.5 0.064 13.3 0.5 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 Cytomega_UL84 PF06284.11 ETO26773.1 - 0.065 11.7 0.4 0.064 11.7 0.4 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein DUF3504 PF12012.8 ETO26773.1 - 0.21 11.5 2.1 0.28 11.1 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) p25-alpha PF05517.12 ETO26774.1 - 0.11 12.6 0.8 1.1 9.4 0.1 2.7 3 0 0 3 3 3 0 p25-alpha DUF3216 PF11505.8 ETO26774.1 - 0.13 12.4 0.3 0.51 10.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3216) PDEase_I PF00233.19 ETO26776.1 - 6e-28 98.2 0.0 6e-28 98.2 0.0 2.0 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase SID-1_RNA_chan PF13965.6 ETO26776.1 - 0.017 13.6 3.0 0.025 13.0 3.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FAA_hydro_N_2 PF18288.1 ETO26776.1 - 0.12 12.8 0.0 0.45 11.0 0.0 2.0 2 0 0 2 2 2 0 Fumarylacetoacetase N-terminal domain 2 Zip PF02535.22 ETO26776.1 - 0.59 9.3 3.5 0.86 8.8 3.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4661 PF15576.6 ETO26776.1 - 1.9 8.4 10.2 2.3 8.0 10.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Host_attach PF10116.9 ETO26777.1 - 0.013 16.0 0.0 0.025 15.2 0.0 1.4 1 0 0 1 1 1 0 Protein required for attachment to host cells SID-1_RNA_chan PF13965.6 ETO26777.1 - 0.017 13.6 3.6 0.013 13.9 2.3 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 CheX PF13690.6 ETO26777.1 - 0.032 14.4 0.1 0.071 13.3 0.1 1.5 1 0 0 1 1 1 0 Chemotaxis phosphatase CheX DUF4834 PF16118.5 ETO26777.1 - 1.3 10.1 4.9 0.6 11.1 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DDHD PF02862.17 ETO26780.1 - 0.0008 19.6 12.5 0.17 12.0 0.6 3.2 3 0 0 3 3 3 2 DDHD domain DUF4834 PF16118.5 ETO26780.1 - 0.028 15.4 3.5 0.028 15.4 3.5 3.8 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Connexin PF00029.19 ETO26780.1 - 0.082 12.7 0.1 0.082 12.7 0.1 2.6 3 0 0 3 3 3 0 Connexin HEAT_2 PF13646.6 ETO26780.1 - 0.14 12.5 0.0 0.49 10.8 0.0 1.9 1 0 0 1 1 1 0 HEAT repeats EPL1 PF10513.9 ETO26780.1 - 0.24 11.8 21.2 1 9.7 9.1 3.4 3 0 0 3 3 3 0 Enhancer of polycomb-like Ctr PF04145.15 ETO26780.1 - 0.7 10.5 9.5 0.88 10.2 0.3 3.2 3 0 0 3 3 3 0 Ctr copper transporter family Zip PF02535.22 ETO26780.1 - 0.94 8.6 11.0 0.14 11.4 0.1 2.9 3 0 0 3 3 3 0 ZIP Zinc transporter Folate_carrier PF01770.18 ETO26780.1 - 1.1 7.9 5.1 0.21 10.3 0.6 2.0 2 0 0 2 2 2 0 Reduced folate carrier Neisseria_TspB PF05616.13 ETO26781.1 - 0.0053 15.3 0.0 0.0061 15.1 0.0 1.1 1 0 0 1 1 1 1 Neisseria meningitidis TspB protein Cyclin_N PF00134.23 ETO26782.1 - 1.3e-31 109.0 1.6 1.3e-31 109.0 1.6 2.1 3 0 0 3 3 3 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO26782.1 - 4.8e-13 49.2 5.2 6.2e-12 45.7 5.2 2.4 1 1 0 1 1 1 1 Cyclin, C-terminal domain Viral_Hsp90 PF03225.14 ETO26783.1 - 0.0048 15.5 1.1 0.006 15.1 1.1 1.3 1 0 0 1 1 1 1 Viral heat shock protein Hsp90 homologue Recep_L_domain PF01030.24 ETO26783.1 - 0.088 12.9 0.1 0.19 11.8 0.1 1.6 1 0 0 1 1 1 0 Receptor L domain Annexin PF00191.20 ETO26784.1 - 0.00071 19.6 0.3 0.0052 16.8 0.1 2.7 2 0 0 2 2 2 1 Annexin Tup_N PF08581.10 ETO26784.1 - 1.2 9.5 39.5 17 5.8 7.5 5.8 3 2 1 4 4 4 0 Tup N-terminal CALCOCO1 PF07888.11 ETO26784.1 - 1.4 7.7 67.1 0.77 8.6 26.6 3.2 1 1 2 3 3 3 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6_N PF17675.1 ETO26784.1 - 3.8 8.0 81.3 1.3 9.6 15.6 4.5 1 1 4 5 5 5 0 Apg6 coiled-coil region eIF3_p135 PF12807.7 ETO26785.1 - 0.58 10.2 5.9 1.1 9.3 2.2 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Secretin_N_2 PF07655.13 ETO26785.1 - 0.76 10.4 22.6 0.87 10.2 10.5 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Pkinase_Tyr PF07714.17 ETO26786.1 - 3.7e-24 85.4 0.7 6.6e-24 84.6 0.7 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO26786.1 - 1.7e-22 80.1 0.7 3.3e-22 79.1 0.7 1.4 1 0 0 1 1 1 1 Protein kinase domain Spt20 PF12090.8 ETO26786.1 - 0.00027 20.6 16.0 0.0005 19.7 16.0 1.4 1 0 0 1 1 1 1 Spt20 family Kinase-like PF14531.6 ETO26786.1 - 0.0045 16.3 0.0 0.0092 15.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like MaoC_dehydratas PF01575.19 ETO26786.1 - 0.076 12.6 0.1 0.24 11.0 0.1 1.8 1 0 0 1 1 1 0 MaoC like domain DUF1056 PF06341.11 ETO26786.1 - 0.61 10.4 9.7 5.4 7.4 1.9 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1056) PNISR PF15996.5 ETO26786.1 - 1.7 8.8 12.1 2.8 8.2 12.1 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NST1 PF13945.6 ETO26786.1 - 2.4 8.2 29.9 4.8 7.3 29.9 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator Nop25 PF09805.9 ETO26786.1 - 4.2 7.8 12.6 7.2 7.1 12.6 1.3 1 0 0 1 1 1 0 Nucleolar protein 12 (25kDa) Sporozoite_P67 PF05642.11 ETO26786.1 - 7.4 4.5 16.5 11 3.9 16.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CPSF100_C PF13299.6 ETO26786.1 - 7.9 6.6 9.8 17 5.6 9.8 1.6 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Cupin_2 PF07883.11 ETO26787.1 - 4.5e-11 42.3 0.1 1.1e-10 41.0 0.1 1.6 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ETO26787.1 - 2.3e-07 30.5 0.0 3.8e-07 29.8 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_8 PF13621.6 ETO26787.1 - 0.021 14.5 1.2 0.057 13.1 0.4 1.6 1 1 1 2 2 2 0 Cupin-like domain Ectoine_synth PF06339.12 ETO26787.1 - 0.044 14.0 0.1 0.062 13.5 0.1 1.2 1 0 0 1 1 1 0 Ectoine synthase Sin_N PF04801.13 ETO26788.1 - 0.13 11.5 36.8 0.25 10.5 36.8 1.4 1 1 0 1 1 1 0 Sin-like protein conserved region DUF1411 PF07199.11 ETO26788.1 - 0.13 11.9 3.5 0.069 12.8 0.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) ABC2_membrane_2 PF12679.7 ETO26788.1 - 0.45 9.7 2.8 0.82 8.9 2.8 1.5 1 0 0 1 1 1 0 ABC-2 family transporter protein Exonuc_VII_L PF02601.15 ETO26788.1 - 4 6.9 35.1 0.19 11.3 7.4 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit PAT1 PF09770.9 ETO26789.1 - 0.71 8.1 21.9 0.83 7.9 21.9 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 DUF4199 PF13858.6 ETO26790.1 - 0.026 14.9 0.0 0.048 14.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) CRC_subunit PF08624.10 ETO26790.1 - 0.038 14.4 0.2 0.086 13.3 0.0 1.6 2 0 0 2 2 2 0 Chromatin remodelling complex Rsc7/Swp82 subunit Methyltransf_16 PF10294.9 ETO26791.1 - 1.8e-15 57.1 6.1 4.3e-14 52.6 6.1 2.3 1 1 0 1 1 1 1 Lysine methyltransferase MTS PF05175.14 ETO26791.1 - 0.0056 16.2 0.0 0.011 15.3 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain PTS_2-RNA PF01885.16 ETO26792.1 - 1.4e-27 96.9 0.4 1.8e-27 96.6 0.4 1.1 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Pkinase PF00069.25 ETO26793.1 - 1.5e-23 83.5 6.0 9.4e-20 71.1 3.3 2.2 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26793.1 - 1.9e-06 27.4 4.9 8.5e-06 25.2 4.9 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ETO26793.1 - 0.00087 19.0 2.8 0.42 10.2 1.2 2.3 1 1 1 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 Kdo PF06293.14 ETO26793.1 - 0.001 18.5 1.0 0.001 18.5 1.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO26793.1 - 0.01 15.7 0.0 0.12 12.3 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO26793.1 - 0.074 11.8 8.8 0.22 10.3 8.5 1.8 1 1 0 1 1 1 0 Fungal protein kinase IPK PF03770.16 ETO26793.1 - 5.9 6.7 9.6 45 3.8 9.6 2.2 1 1 0 1 1 1 0 Inositol polyphosphate kinase BTB PF00651.31 ETO26794.1 - 0.0011 19.2 0.2 0.53 10.5 0.0 2.6 2 0 0 2 2 2 2 BTB/POZ domain BEX PF04538.12 ETO26794.1 - 0.085 13.5 2.1 0.15 12.7 2.1 1.3 1 0 0 1 1 1 0 Brain expressed X-linked like family RXT2_N PF08595.11 ETO26794.1 - 3.8 7.5 9.2 0.96 9.5 5.4 1.9 1 1 1 2 2 2 0 RXT2-like, N-terminal Pkinase PF00069.25 ETO26796.1 - 1.3e-18 67.3 0.0 2.1e-18 66.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26796.1 - 7.7e-05 22.1 0.0 0.00011 21.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO26797.1 - 8.7e-29 100.7 0.2 1.2e-28 100.2 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26797.1 - 7.5e-10 38.5 0.2 1.2e-09 37.9 0.2 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase RGS PF00615.19 ETO26797.1 - 0.00068 19.9 0.1 0.0017 18.6 0.0 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain SAC3 PF12209.8 ETO26797.1 - 0.05 13.8 0.3 0.15 12.3 0.1 1.9 2 0 0 2 2 2 0 Leucine permease transcriptional regulator helical domain FOXP-CC PF16159.5 ETO26798.1 - 0.0051 17.4 2.0 0.0051 17.4 2.0 3.1 3 1 0 3 3 3 1 FOXP coiled-coil domain zf_UBZ PF18439.1 ETO26798.1 - 0.071 12.7 16.4 5.9 6.6 0.2 6.2 6 0 0 6 6 6 0 Ubiquitin-Binding Zinc Finger zf-C2H2_4 PF13894.6 ETO26798.1 - 0.17 12.8 27.6 2.2 9.3 0.0 7.0 6 1 1 7 7 7 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO26798.1 - 4.8 7.8 20.5 13 6.5 0.0 6.0 6 0 0 6 6 6 0 Zinc finger, C2H2 type WD40 PF00400.32 ETO26799.1 - 6.7e-67 219.8 21.3 1.3e-09 38.5 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26799.1 - 2.5e-20 72.6 3.3 0.0083 16.4 0.0 6.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26799.1 - 3.4e-14 52.6 5.3 0.0016 17.5 0.1 5.1 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO26799.1 - 2.4e-06 26.3 0.2 4.2e-05 22.3 0.1 2.5 1 1 1 2 2 2 1 Cytochrome D1 heme domain PD40 PF07676.12 ETO26799.1 - 9.9e-06 25.4 1.9 1.9 8.5 0.0 4.0 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO26799.1 - 1.1e-05 24.4 7.9 0.86 8.2 0.0 5.2 1 1 6 7 7 7 3 Nucleoporin Nup120/160 SBD PF17882.1 ETO26799.1 - 2.7e-05 24.0 0.5 0.68 9.8 0.0 4.4 1 1 4 5 5 5 1 OAA-family lectin sugar binding domain Nbas_N PF15492.6 ETO26799.1 - 0.00012 21.5 1.2 2.3 7.5 0.0 3.8 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO26799.1 - 0.00055 20.0 3.2 7.3 6.7 0.3 4.3 2 2 1 3 3 3 1 Family of unknown function (DUF5570) DPPIV_N PF00930.21 ETO26799.1 - 0.0034 16.2 0.1 1.3 7.7 0.0 3.4 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Ubiquitin_3 PF14836.6 ETO26799.1 - 0.0064 16.4 0.0 7.4 6.6 0.0 3.4 2 1 1 3 3 3 1 Ubiquitin-like domain Nucleoporin_N PF08801.11 ETO26799.1 - 0.011 14.5 3.7 2.5 6.7 0.1 3.6 2 2 2 4 4 4 0 Nup133 N terminal like BBS2_Mid PF14783.6 ETO26799.1 - 0.031 14.3 1.2 8.5 6.5 0.1 4.4 3 2 2 5 5 5 0 Ciliary BBSome complex subunit 2, middle region DUF3913 PF13052.6 ETO26799.1 - 0.058 13.7 0.2 0.4 11.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3913) Resistin PF06954.11 ETO26799.1 - 0.27 11.8 4.3 20 5.8 0.1 3.5 2 1 1 3 3 3 0 Resistin Proteasome_A_N PF10584.9 ETO26799.1 - 8 6.2 7.4 90 2.9 0.0 4.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature MTHFR PF02219.17 ETO26800.1 - 2.1e-90 302.9 0.0 1.5e-89 300.2 0.0 2.2 1 1 0 1 1 1 1 Methylenetetrahydrofolate reductase PPR_2 PF13041.6 ETO26801.1 - 0.00068 19.8 1.6 0.016 15.4 1.0 3.1 3 0 0 3 3 3 1 PPR repeat family DUF3067 PF11267.8 ETO26801.1 - 0.3 11.7 5.5 3.4 8.3 0.4 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF3067) GP24_25 PF17388.2 ETO26803.1 - 0.033 14.2 0.3 0.059 13.4 0.3 1.3 1 0 0 1 1 1 0 Tail assembly gene products 24 & 25 WD40 PF00400.32 ETO26805.1 - 7.1e-21 74.1 12.5 6.5e-08 33.1 1.6 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO26805.1 - 4.3e-08 32.3 1.9 0.012 14.3 0.2 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO26805.1 - 3.3e-07 30.5 0.1 0.03 14.6 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO26805.1 - 0.00029 20.3 3.0 0.0029 17.0 1.8 2.1 1 1 0 2 2 2 1 WD40-like domain HARP PF07443.13 ETO26805.1 - 0.03 14.0 0.2 3 7.6 0.0 2.7 3 0 0 3 3 3 0 HepA-related protein (HARP) Actin_micro PF17003.5 ETO26805.1 - 0.22 10.7 5.8 0.25 10.5 5.0 1.4 1 1 0 1 1 1 0 Putative actin-like family WD40 PF00400.32 ETO26806.1 - 7e-06 26.7 1.8 5.8e-05 23.8 0.1 3.1 3 1 0 3 3 3 1 WD domain, G-beta repeat Arm_3 PF16186.5 ETO26806.1 - 0.024 14.2 1.4 0.13 11.8 0.4 2.3 2 0 0 2 2 2 0 Atypical Arm repeat Ank_2 PF12796.7 ETO26807.1 - 0.002 18.7 1.3 0.0076 16.8 0.1 2.6 3 1 0 3 3 3 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO26807.1 - 0.014 15.9 0.0 0.039 14.5 0.0 1.8 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Methyltransf_11 PF08241.12 ETO26807.1 - 0.02 15.5 0.4 0.07 13.8 0.1 2.1 2 0 0 2 2 2 0 Methyltransferase domain Ank_3 PF13606.6 ETO26807.1 - 0.045 14.3 0.8 5.2 8.0 0.0 3.3 3 0 0 3 3 3 0 Ankyrin repeat UCH PF00443.29 ETO26808.1 - 7.7e-23 81.3 1.3 1.1e-22 80.8 1.3 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO26808.1 - 1.3e-06 28.3 12.1 0.00035 20.3 5.7 2.4 1 1 1 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase PBD PF00786.28 ETO26808.1 - 0.12 12.7 2.0 0.22 11.9 0.7 2.1 1 1 1 2 2 2 0 P21-Rho-binding domain TMEM100 PF16311.5 ETO26808.1 - 0.4 10.3 3.7 0.48 10.0 0.4 2.7 2 1 0 2 2 2 0 Transmembrane protein 100 PRIMA1 PF16101.5 ETO26808.1 - 1.7 8.7 10.1 4.2 7.4 10.1 1.7 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ERM PF00769.19 ETO26809.1 - 0.00037 20.4 8.4 0.00037 20.4 8.4 6.1 4 2 1 5 5 5 2 Ezrin/radixin/moesin family TMF_TATA_bd PF12325.8 ETO26809.1 - 0.0078 16.4 16.3 0.0078 16.4 16.3 9.2 7 1 3 10 10 10 1 TATA element modulatory factor 1 TATA binding MbeD_MobD PF04899.12 ETO26809.1 - 0.065 13.4 5.8 3.6 7.8 0.7 4.5 2 1 0 3 3 3 0 MbeD/MobD like CAP_GLY PF01302.25 ETO26811.1 - 1.8e-12 47.1 1.7 1.8e-12 47.1 1.7 2.0 2 0 0 2 2 2 1 CAP-Gly domain Macoilin PF09726.9 ETO26811.1 - 0.059 11.9 2.4 0.06 11.9 2.4 1.1 1 0 0 1 1 1 0 Macoilin family Menin PF05053.13 ETO26811.1 - 6.1 5.1 8.4 8.1 4.7 8.4 1.1 1 0 0 1 1 1 0 Menin Apis_Csd PF11671.8 ETO26811.1 - 8.8 6.3 11.2 13 5.8 10.6 1.5 1 1 0 1 1 1 0 Complementary sex determiner protein Ctr PF04145.15 ETO26812.1 - 0.0032 18.1 4.2 0.0062 17.2 4.2 1.5 1 0 0 1 1 1 1 Ctr copper transporter family TFIIF_alpha PF05793.12 ETO26814.1 - 1.2 7.7 48.4 1.5 7.3 48.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RVT_1 PF00078.27 ETO26815.1 - 1.2e-20 74.0 0.0 4.1e-20 72.3 0.0 1.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) bZIP_1 PF00170.21 ETO26817.1 - 0.018 15.2 4.5 0.46 10.6 1.4 2.3 2 0 0 2 2 2 0 bZIP transcription factor Csm1_N PF18504.1 ETO26817.1 - 0.022 15.1 9.0 2.5 8.5 5.1 2.5 2 1 0 2 2 2 0 Csm1 N-terminal domain ZapB PF06005.12 ETO26817.1 - 0.048 14.1 12.4 0.45 11.0 5.9 2.2 2 0 0 2 2 2 0 Cell division protein ZapB Terminase_4 PF05119.12 ETO26817.1 - 0.062 13.7 0.8 0.1 13.0 0.8 1.4 1 0 0 1 1 1 0 Phage terminase, small subunit KxDL PF10241.9 ETO26817.1 - 3.1 8.2 9.4 2.1 8.7 4.5 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein Bap31_Bap29_C PF18035.1 ETO26817.1 - 4.1 7.5 7.1 8.4 6.5 5.7 2.1 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain Kelch_6 PF13964.6 ETO26818.1 - 0.0001 22.5 0.7 0.00018 21.7 0.7 1.4 1 0 0 1 1 1 1 Kelch motif Kelch_3 PF13415.6 ETO26818.1 - 0.00015 21.9 0.2 0.00025 21.3 0.2 1.3 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO26818.1 - 0.00068 19.6 0.7 0.0011 18.9 0.7 1.3 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO26818.1 - 0.0014 18.2 0.7 0.0022 17.5 0.7 1.4 1 0 0 1 1 1 1 Kelch motif DUF4252 PF14060.6 ETO26818.1 - 0.067 13.1 0.1 0.12 12.3 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4252) PIG-S PF10510.9 ETO26819.1 - 2e-52 178.7 0.9 2.4e-52 178.5 0.9 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-glycan biosynthesis class S protein EI24 PF07264.11 ETO26820.1 - 0.0049 17.1 7.1 0.088 13.0 5.3 2.7 1 1 1 2 2 2 1 Etoposide-induced protein 2.4 (EI24) FtsX PF02687.21 ETO26820.1 - 2.5 8.6 7.3 0.28 11.7 0.2 2.4 1 1 1 2 2 2 0 FtsX-like permease family DUF2207 PF09972.9 ETO26820.1 - 7.8 5.1 7.6 11 4.6 3.7 2.3 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) eIF-6 PF01912.18 ETO26823.1 - 1.7e-77 259.3 0.8 3.3e-77 258.3 0.8 1.5 1 0 0 1 1 1 1 eIF-6 family FtsX PF02687.21 ETO26823.1 - 1.3e-12 48.0 24.8 9e-09 35.7 7.4 6.2 6 0 0 6 6 6 3 FtsX-like permease family Adeno_E1B_19K PF01691.16 ETO26823.1 - 0.054 13.0 0.0 0.13 11.8 0.0 1.6 1 0 0 1 1 1 0 Adenovirus E1B 19K protein / small t-antigen Nucleotid_trans PF03407.16 ETO26825.1 - 1.1e-06 28.8 0.1 5e-06 26.6 0.2 1.9 2 0 0 2 2 2 1 Nucleotide-diphospho-sugar transferase ERG4_ERG24 PF01222.17 ETO26826.1 - 4.8e-58 196.9 29.6 5.6e-58 196.7 29.6 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family S6PP PF05116.13 ETO26827.1 - 3.7e-33 115.1 1.3 8.6e-20 71.3 0.0 2.9 3 0 0 3 3 3 2 Sucrose-6F-phosphate phosphohydrolase Hydrolase_3 PF08282.12 ETO26827.1 - 6.5e-08 32.6 0.0 4.5e-05 23.3 0.0 2.2 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase DnaT PF17948.1 ETO26827.1 - 0.0039 16.9 3.6 0.01 15.5 3.6 1.7 1 0 0 1 1 1 1 DnaT DNA-binding domain HAD PF12710.7 ETO26827.1 - 0.061 13.7 0.0 1 9.8 0.0 2.5 2 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF5085 PF16895.5 ETO26827.1 - 0.1 12.9 1.6 5.8 7.3 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5085) SLC12 PF03522.15 ETO26828.1 - 1.8e-41 142.6 6.2 1.4e-16 60.6 0.0 4.8 1 1 3 4 4 4 3 Solute carrier family 12 AA_permease PF00324.21 ETO26828.1 - 4.8e-17 61.7 14.4 1.4e-13 50.2 8.2 2.1 1 1 1 2 2 2 2 Amino acid permease DUF2670 PF10875.8 ETO26828.1 - 0.083 13.0 0.0 0.19 11.8 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) Pkinase PF00069.25 ETO26829.1 - 9.1e-06 25.2 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain DUF3342 PF11822.8 ETO26831.1 - 0.043 14.0 0.3 0.049 13.8 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) CAP_GLY PF01302.25 ETO26832.1 - 6.4e-53 176.7 11.3 7e-21 74.0 0.1 3.3 3 0 0 3 3 3 3 CAP-Gly domain EF-hand_1 PF00036.32 ETO26832.1 - 2.2e-10 39.3 0.1 3.4e-05 23.1 0.0 3.0 3 0 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 ETO26832.1 - 8.4e-10 39.0 0.0 2.5e-09 37.5 0.0 1.8 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO26832.1 - 1.3e-08 34.1 0.0 0.0023 17.7 0.0 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO26832.1 - 2.5e-06 27.2 0.0 5.9e-05 22.8 0.0 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO26832.1 - 3.5e-06 26.3 0.1 0.0017 17.8 0.0 2.6 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 ETO26832.1 - 5.2e-05 23.5 0.1 5.2e-05 23.5 0.1 3.1 3 0 0 3 3 3 1 Secreted protein acidic and rich in cysteine Ca binding region zf-GRF PF06839.12 ETO26832.1 - 0.5 10.5 5.6 18 5.5 0.1 3.4 3 0 0 3 3 3 0 GRF zinc finger Archease PF01951.16 ETO26833.1 - 8e-44 149.2 0.2 9.6e-44 149.0 0.2 1.0 1 0 0 1 1 1 1 Archease protein family (MTH1598/TM1083) TPR_17 PF13431.6 ETO26834.1 - 4.5e-15 54.8 7.2 0.0041 17.4 0.3 6.0 5 2 1 6 6 6 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26834.1 - 3.8e-13 48.9 3.7 8.1e-06 25.4 0.5 5.6 4 2 2 6 6 6 2 TPR repeat TPR_12 PF13424.6 ETO26834.1 - 4e-11 43.0 7.3 0.086 13.1 0.1 5.5 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26834.1 - 4e-10 39.1 16.3 0.014 15.5 0.0 7.4 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26834.1 - 7.2e-10 38.2 15.0 0.048 13.8 1.1 7.6 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO26834.1 - 1.1e-09 37.7 22.6 0.0043 16.8 1.0 7.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26834.1 - 3.9e-09 36.6 0.2 1.5 9.9 0.0 5.7 4 3 2 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26834.1 - 1.8e-07 31.5 3.7 0.022 15.3 0.1 5.4 5 1 1 6 6 6 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO26834.1 - 1.3e-05 24.6 0.2 0.34 10.1 0.0 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO26834.1 - 0.0008 19.6 5.8 0.0082 16.3 2.8 4.8 2 1 3 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_7 PF13176.6 ETO26834.1 - 0.0019 18.1 5.0 4 7.7 0.2 5.4 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO26834.1 - 0.0036 17.4 1.0 3.4 7.9 0.0 4.0 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO26834.1 - 0.014 16.0 0.4 60 4.4 0.1 3.8 4 1 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO26834.1 - 0.058 13.3 9.6 23 5.0 0.3 5.2 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO26834.1 - 0.069 13.8 3.2 1.2e+02 3.6 0.0 5.1 5 1 0 5 5 5 0 Tetratricopeptide repeat PH PF00169.29 ETO26835.1 - 4e-08 33.7 0.9 4e-08 33.7 0.9 1.9 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO26835.1 - 0.00017 21.8 0.8 0.00034 20.8 0.8 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ETO26835.1 - 0.00095 19.2 0.7 0.00095 19.2 0.7 1.6 2 0 0 2 2 2 1 PH domain Myosin_TH1 PF06017.13 ETO26835.1 - 0.0025 17.5 0.5 0.0033 17.1 0.5 1.3 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding DUF5018 PF16410.5 ETO26835.1 - 0.013 14.3 0.0 0.02 13.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5018) PH_11 PF15413.6 ETO26835.1 - 0.032 14.7 1.8 0.032 14.7 1.8 2.9 2 2 0 2 2 2 0 Pleckstrin homology domain ABC2_membrane_3 PF12698.7 ETO26835.1 - 2.5 7.1 11.8 7.7 5.5 8.7 2.0 1 1 1 2 2 2 0 ABC-2 family transporter protein ubiquitin PF00240.23 ETO26836.1 - 4.2e-20 71.3 0.3 1e-19 70.1 0.1 1.7 2 0 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ETO26836.1 - 2.6e-12 46.4 0.3 4.9e-12 45.5 0.3 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_4 PF18036.1 ETO26836.1 - 2.3e-08 34.0 0.3 0.00031 20.7 0.1 2.3 1 1 1 2 2 2 2 Ubiquitin-like domain Ubiquitin_2 PF14560.6 ETO26836.1 - 3.9e-05 24.0 0.1 7.8e-05 23.1 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin-like domain DUF2407 PF10302.9 ETO26836.1 - 0.0008 19.9 0.1 0.0014 19.1 0.1 1.4 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain TBK1_ULD PF18396.1 ETO26836.1 - 0.0012 18.7 0.0 0.0031 17.4 0.0 1.6 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain DUF4896 PF16237.5 ETO26836.1 - 0.042 13.7 3.2 0.042 13.7 3.2 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4896) UBX PF00789.20 ETO26836.1 - 0.066 13.4 0.1 0.13 12.5 0.1 1.4 1 0 0 1 1 1 0 UBX domain DUF3793 PF12672.7 ETO26838.1 - 0.067 13.2 0.5 0.17 11.9 0.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3793) Macoilin PF09726.9 ETO26839.1 - 2.8 6.4 14.2 3.9 5.9 14.2 1.1 1 0 0 1 1 1 0 Macoilin family Ank PF00023.30 ETO26840.1 - 9.9e-06 25.8 1.4 0.00035 20.9 0.0 3.6 3 1 1 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 ETO26840.1 - 1.1e-05 25.9 0.1 0.00036 21.0 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO26840.1 - 0.0001 22.4 0.1 0.039 14.5 0.0 3.6 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO26840.1 - 0.00073 20.0 0.1 0.094 13.3 0.0 3.9 4 2 1 5 5 5 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO26840.1 - 0.0016 18.7 0.2 0.24 11.8 0.1 3.5 3 1 0 3 3 3 1 Ankyrin repeats (many copies) E2F_CC-MB PF16421.5 ETO26840.1 - 0.032 14.6 1.4 1.4 9.3 0.1 3.2 3 0 0 3 3 3 0 E2F transcription factor CC-MB domain Tet_JBP PF12851.7 ETO26841.1 - 0.00015 21.2 0.3 0.00094 18.6 0.0 2.1 1 1 2 3 3 3 1 Oxygenase domain of the 2OGFeDO superfamily NAD_binding_2 PF03446.15 ETO26841.1 - 0.0021 18.2 0.4 0.035 14.3 0.2 2.2 2 0 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase NOC3p PF07540.11 ETO26841.1 - 0.054 13.9 0.3 0.3 11.6 0.1 2.3 1 1 1 2 2 2 0 Nucleolar complex-associated protein DUF2587 PF10759.9 ETO26841.1 - 0.1 12.1 0.0 0.21 11.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2587) AAA PF00004.29 ETO26842.1 - 1.2e-35 122.8 0.0 2.4e-35 121.8 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO26842.1 - 5.4e-10 38.9 0.1 1.1e-09 37.9 0.1 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_2 PF07724.14 ETO26842.1 - 9e-08 32.4 0.0 1.6e-07 31.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO26842.1 - 4.2e-05 23.8 0.2 0.0093 16.2 0.2 2.6 1 1 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO26842.1 - 9.7e-05 22.4 0.1 0.00041 20.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO26842.1 - 0.00057 20.3 0.1 0.0024 18.3 0.1 2.0 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 ETO26842.1 - 0.00061 19.2 0.0 0.00099 18.5 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI RuvB_N PF05496.12 ETO26842.1 - 0.00095 18.9 0.0 0.0021 17.8 0.0 1.5 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain ABC_tran PF00005.27 ETO26842.1 - 0.0015 19.0 0.1 0.0045 17.5 0.0 1.8 2 0 0 2 2 1 1 ABC transporter DUF2075 PF09848.9 ETO26842.1 - 0.0018 17.6 0.3 0.0079 15.5 0.3 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) AAA_3 PF07726.11 ETO26842.1 - 0.0023 17.8 0.0 0.0046 16.8 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Baculo_11_kDa PF06143.11 ETO26842.1 - 0.0031 17.1 0.2 0.0031 17.1 0.2 2.2 2 1 0 2 2 1 1 Baculovirus 11 kDa family AAA_18 PF13238.6 ETO26842.1 - 0.0037 17.8 0.1 0.01 16.4 0.0 1.9 2 0 0 2 2 1 1 AAA domain AAA_24 PF13479.6 ETO26842.1 - 0.0037 17.0 0.0 0.012 15.3 0.0 1.8 2 0 0 2 2 2 1 AAA domain TIP49 PF06068.13 ETO26842.1 - 0.0043 16.3 0.0 0.007 15.6 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain ResIII PF04851.15 ETO26842.1 - 0.0094 16.0 0.0 0.044 13.8 0.0 2.0 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_33 PF13671.6 ETO26842.1 - 0.015 15.5 0.0 0.054 13.7 0.0 2.0 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO26842.1 - 0.031 14.7 0.0 0.065 13.6 0.0 1.6 1 0 0 1 1 1 0 RNA helicase AAA_11 PF13086.6 ETO26842.1 - 0.038 13.8 0.0 0.066 13.0 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO26842.1 - 0.038 14.0 0.0 0.077 13.0 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ETO26842.1 - 0.057 12.9 0.0 0.097 12.2 0.0 1.3 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_14 PF13173.6 ETO26842.1 - 0.072 13.1 0.0 0.17 11.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO26842.1 - 0.087 12.7 1.4 0.26 11.2 0.0 2.4 3 0 0 3 3 3 0 NACHT domain Shisa PF13908.6 ETO26842.1 - 0.087 13.1 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator NB-ARC PF00931.22 ETO26842.1 - 0.1 11.8 0.0 0.18 11.0 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain AAA_19 PF13245.6 ETO26842.1 - 0.12 12.7 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain SP_C-Propep PF08999.10 ETO26842.1 - 0.16 11.8 0.2 0.46 10.3 0.2 1.7 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide DUF4834 PF16118.5 ETO26842.1 - 7.6 7.6 7.9 49 5.0 5.8 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TMEMspv1-c74-12 PF11044.8 ETO26843.1 - 6.7 6.8 6.3 0.36 10.9 0.3 2.0 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein YL1 PF05764.13 ETO26845.1 - 0.00011 22.4 24.5 0.00014 22.1 24.5 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC45 PF02724.14 ETO26845.1 - 0.00021 19.7 18.1 0.00023 19.6 18.1 1.1 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO26845.1 - 0.00022 19.6 19.0 0.00023 19.6 19.0 1.1 1 0 0 1 1 1 1 Nop14-like family BUD22 PF09073.10 ETO26845.1 - 0.0038 16.6 16.6 0.0038 16.6 16.6 1.4 2 0 0 2 2 2 1 BUD22 SDA1 PF05285.12 ETO26845.1 - 0.0051 16.3 23.0 0.006 16.1 23.0 1.1 1 0 0 1 1 1 1 SDA1 RRN3 PF05327.11 ETO26845.1 - 0.02 13.5 16.8 0.023 13.3 16.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Merozoite_SPAM PF07133.11 ETO26845.1 - 0.029 14.4 26.6 0.038 14.0 26.6 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Rrn6 PF10214.9 ETO26845.1 - 0.081 11.4 3.9 0.088 11.3 3.9 1.2 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF913 PF06025.12 ETO26845.1 - 0.27 10.2 3.8 0.31 10.0 3.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) AGH PF17558.2 ETO26845.1 - 0.37 11.0 5.2 0.57 10.4 5.2 1.3 1 0 0 1 1 1 0 Androgenic gland hormone IFT57 PF10498.9 ETO26845.1 - 0.49 9.3 17.5 0.63 8.9 17.5 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 RNA_polI_A34 PF08208.11 ETO26845.1 - 1.1 9.3 17.8 1.4 9.0 17.8 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 RNA_pol_Rpc4 PF05132.14 ETO26845.1 - 1.1 9.7 4.9 1.7 9.1 4.9 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop53 PF07767.11 ETO26845.1 - 1.3 8.4 27.4 2 7.7 27.4 1.3 1 1 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3381 PF11861.8 ETO26845.1 - 2.4 7.9 23.5 0.4 10.5 19.4 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Presenilin PF01080.17 ETO26845.1 - 3.4 6.3 7.1 3.6 6.2 7.1 1.1 1 0 0 1 1 1 0 Presenilin Astro_capsid_p PF12226.8 ETO26845.1 - 9.9 5.2 21.9 13 4.8 21.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein Borrelia_REV PF03978.13 ETO26846.1 - 0.0024 17.9 0.9 0.0048 16.9 0.9 1.6 1 0 0 1 1 1 1 Borrelia burgdorferi REV protein Atg14 PF10186.9 ETO26846.1 - 0.1 11.7 6.8 0.13 11.3 6.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Exonuc_VII_L PF02601.15 ETO26846.1 - 0.17 11.4 6.2 0.2 11.2 6.2 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit APG6_N PF17675.1 ETO26846.1 - 0.27 11.8 12.3 0.46 11.0 12.3 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region ADIP PF11559.8 ETO26846.1 - 0.48 10.5 13.8 0.57 10.3 12.9 1.5 1 1 0 1 1 1 0 Afadin- and alpha -actinin-Binding FAM76 PF16046.5 ETO26846.1 - 0.91 8.8 10.8 1.1 8.5 10.8 1.1 1 0 0 1 1 1 0 FAM76 protein SlyX PF04102.12 ETO26846.1 - 3.3 8.4 10.5 17 6.1 0.3 2.8 1 1 2 3 3 3 0 SlyX DUF1664 PF07889.12 ETO26846.1 - 3.4 7.7 11.3 7.6 6.6 6.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF16 PF01519.16 ETO26846.1 - 3.7 8.1 14.0 21 5.6 14.3 1.9 1 1 1 2 2 2 0 Protein of unknown function DUF16 TMPIT PF07851.13 ETO26846.1 - 5.2 6.2 11.8 7.4 5.7 11.1 1.6 1 1 0 1 1 1 0 TMPIT-like protein FKBP_C PF00254.28 ETO26847.1 - 7.3e-12 45.4 0.0 1.3e-11 44.7 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase DENN PF02141.21 ETO26848.1 - 1.2e-33 116.7 3.5 1.8e-33 116.0 3.5 1.3 1 0 0 1 1 1 1 DENN (AEX-3) domain Mem_trans PF03547.18 ETO26850.1 - 0.078 11.4 0.4 0.077 11.4 0.4 1.2 1 0 0 1 1 1 0 Membrane transport protein Zn_clus PF00172.18 ETO26850.1 - 1.8 8.8 10.4 1.2 9.3 7.3 2.3 2 0 0 2 2 2 0 Fungal Zn(2)-Cys(6) binuclear cluster domain DUF2076 PF09849.9 ETO26850.1 - 4 7.4 18.8 7.8 6.5 18.8 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) NPR3 PF03666.13 ETO26850.1 - 6.4 5.4 12.6 11 4.6 12.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Dsh_C PF12316.8 ETO26850.1 - 7.7 6.9 17.8 3.2 8.1 14.2 2.0 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal WD40 PF00400.32 ETO26851.1 - 9.9e-66 216.1 14.4 2e-11 44.2 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26851.1 - 6.1e-26 90.6 0.5 0.00018 21.8 0.1 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO26851.1 - 4.7e-13 49.4 0.0 1.6e-08 34.6 0.0 2.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO26851.1 - 3.8e-12 45.8 0.0 0.19 10.7 0.0 5.3 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO26851.1 - 8.6e-11 41.7 0.5 8e-05 22.1 0.1 3.3 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO26851.1 - 5.2e-09 35.3 1.7 0.2 10.2 0.0 4.9 1 1 2 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO26851.1 - 8.6e-07 28.7 1.3 4.1 7.5 0.0 4.7 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO26851.1 - 0.00012 20.9 2.6 3.3 6.3 0.2 4.5 1 1 3 4 4 4 2 Nup133 N terminal like BBS2_Mid PF14783.6 ETO26851.1 - 0.0016 18.4 1.0 37 4.4 0.0 5.1 3 2 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region HPS6 PF15702.5 ETO26851.1 - 0.0041 15.2 0.1 0.57 8.1 0.0 3.5 2 1 3 5 5 5 1 Hermansky-Pudlak syndrome 6 protein PQQ_2 PF13360.6 ETO26851.1 - 0.0078 15.8 0.0 0.15 11.6 0.0 1.7 1 1 1 2 2 2 2 PQQ-like domain DPPIV_N PF00930.21 ETO26851.1 - 0.0085 14.9 0.2 22 3.7 0.0 3.9 1 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region NHL PF01436.21 ETO26851.1 - 0.015 15.3 0.0 2.1 8.5 0.0 3.0 2 0 0 2 2 2 0 NHL repeat Cytochrom_D1 PF02239.16 ETO26851.1 - 0.017 13.7 0.2 1.8 7.0 0.1 2.6 1 1 2 3 3 3 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO26851.1 - 0.029 14.0 4.5 38 4.1 0.0 4.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Roc PF08477.13 ETO26851.1 - 0.13 12.5 0.3 9.8 6.4 0.0 3.3 2 1 1 4 4 4 0 Ras of Complex, Roc, domain of DAPkinase DEAD PF00270.29 ETO26852.1 - 5.7e-36 123.9 0.0 2.7e-35 121.7 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO26852.1 - 1e-30 106.4 0.0 3.4e-30 104.6 0.0 2.0 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Laps PF10169.9 ETO26852.1 - 0.95 10.0 8.4 0.096 13.3 2.7 2.2 2 0 0 2 2 2 0 Learning-associated protein WD40 PF00400.32 ETO26853.1 - 5.1e-28 96.7 2.2 6.8e-08 33.1 0.0 4.7 4 1 1 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26853.1 - 1.1e-12 48.1 0.0 1.7e-06 28.2 0.0 3.7 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26853.1 - 7.1e-08 31.8 0.1 0.018 14.0 0.0 3.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO26853.1 - 0.00019 20.1 0.3 0.011 14.3 0.0 1.6 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO26853.1 - 0.00024 21.0 0.1 7.5 6.6 0.0 4.4 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO26853.1 - 0.004 15.9 1.6 0.37 9.5 0.4 2.2 1 1 1 2 2 2 2 Nup133 N terminal like Utp8 PF10395.9 ETO26853.1 - 0.012 14.2 0.1 0.032 12.7 0.0 1.8 1 1 1 2 2 2 0 Utp8 family Nup160 PF11715.8 ETO26853.1 - 0.041 12.5 0.1 6 5.4 0.0 2.6 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Lactonase PF10282.9 ETO26853.1 - 0.13 11.5 0.0 0.49 9.6 0.0 1.9 1 1 1 2 2 2 0 Lactonase, 7-bladed beta-propeller Proteasome_A_N PF10584.9 ETO26853.1 - 3.6 7.4 6.7 31 4.4 0.1 4.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature G-alpha PF00503.20 ETO26854.1 - 1.7e-12 47.2 2.3 2e-12 46.9 2.3 1.0 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO26854.1 - 0.021 15.3 1.2 0.022 15.3 0.3 1.5 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ETO26854.1 - 0.036 13.8 0.0 0.062 13.0 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO26854.1 - 0.055 13.4 0.1 0.063 13.2 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase Roc PF08477.13 ETO26854.1 - 0.082 13.1 0.7 0.18 12.0 0.1 1.9 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase DHHC PF01529.20 ETO26855.1 - 3.7e-14 53.0 1.2 3.7e-14 53.0 1.2 1.6 2 0 0 2 2 2 1 DHHC palmitoyltransferase Abhydro_lipase PF04083.16 ETO26855.1 - 0.067 12.8 1.2 3.6 7.3 0.3 2.3 2 0 0 2 2 2 0 Partial alpha/beta-hydrolase lipase region DUF202 PF02656.15 ETO26855.1 - 0.4 11.1 2.4 0.41 11.1 0.5 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF202) SNARE PF05739.19 ETO26856.1 - 0.13 12.3 0.0 0.24 11.4 0.0 1.4 1 0 0 1 1 1 0 SNARE domain MA3 PF02847.17 ETO26857.1 - 5.6e-21 74.6 0.1 4.2e-11 42.8 0.1 2.8 2 1 0 2 2 2 2 MA3 domain Peroxin-3 PF04882.12 ETO26858.1 - 0.019 14.0 0.5 0.031 13.3 0.4 1.4 1 1 0 1 1 1 0 Peroxin-3 Pkinase PF00069.25 ETO26859.1 - 1.1e-20 74.1 0.0 1.6e-20 73.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26859.1 - 0.0082 15.5 0.1 0.013 14.8 0.1 1.5 1 1 0 1 1 1 1 Protein tyrosine kinase PHTB1_N PF14727.6 ETO26860.1 - 1.2e-42 146.7 0.0 1.6e-42 146.3 0.0 1.1 1 0 0 1 1 1 1 PTHB1 N-terminus UBA_e1_thiolCys PF10585.9 ETO26861.1 - 1.1e-96 323.6 5.9 1.8e-96 323.0 5.9 1.3 1 0 0 1 1 1 1 Ubiquitin-activating enzyme active site ThiF PF00899.21 ETO26861.1 - 3.4e-60 203.4 0.0 4.5e-60 203.0 0.0 1.1 1 0 0 1 1 1 1 ThiF family E1_UFD PF09358.10 ETO26861.1 - 3e-26 91.9 0.2 9.1e-26 90.4 0.2 1.9 1 0 0 1 1 1 1 Ubiquitin fold domain E1_FCCH PF16190.5 ETO26862.1 - 1.2e-28 99.1 0.1 2.5e-28 98.1 0.1 1.6 1 0 0 1 1 1 1 Ubiquitin-activating enzyme E1 FCCH domain E1_4HB PF16191.5 ETO26862.1 - 1.2e-14 54.3 1.6 4.4e-08 33.2 0.1 2.8 3 0 0 3 3 3 2 Ubiquitin-activating enzyme E1 four-helix bundle ThiF PF00899.21 ETO26862.1 - 2.8e-07 30.2 0.0 1e-06 28.3 0.0 1.8 2 1 0 2 2 2 1 ThiF family ThiF PF00899.21 ETO26863.1 - 0.00014 21.3 0.0 0.00018 20.9 0.0 1.1 1 0 0 1 1 1 1 ThiF family Paf67 PF10255.9 ETO26864.1 - 1.2e-110 370.3 8.0 1.7e-110 369.8 8.0 1.1 1 0 0 1 1 1 1 RNA polymerase I-associated factor PAF67 G-gamma PF00631.22 ETO26864.1 - 0.021 14.8 0.3 0.08 13.0 0.3 2.0 1 0 0 1 1 1 0 GGL domain ABC2_membrane PF01061.24 ETO26865.1 - 1.1e-28 100.1 15.8 1.6e-28 99.6 15.8 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO26865.1 - 0.2 10.7 14.0 0.14 11.2 12.5 1.4 1 1 0 1 1 1 0 ABC-2 family transporter protein PHTB1_C PF14728.6 ETO26866.1 - 3.6e-34 118.5 1.7 4.5e-34 118.2 1.7 1.0 1 0 0 1 1 1 1 PTHB1 C-terminus DUF3847 PF12958.7 ETO26866.1 - 0.077 13.1 1.3 0.18 12.0 1.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3847) Mucin15 PF15672.5 ETO26867.1 - 1.1 8.7 8.1 0.56 9.6 6.1 1.5 2 0 0 2 2 2 0 Cell-membrane associated Mucin15 WD40 PF00400.32 ETO26868.1 - 7.9e-61 200.6 15.1 9.7e-09 35.7 0.1 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26868.1 - 5.6e-19 68.2 1.0 0.00045 20.4 0.0 7.6 3 1 6 9 9 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26868.1 - 1.7e-17 63.4 1.1 0.0059 15.6 0.1 7.8 2 1 6 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO26868.1 - 1.9e-11 43.6 5.5 0.0066 16.4 0.1 7.2 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO26868.1 - 5.3e-07 29.3 17.8 0.0019 17.6 0.0 5.4 2 2 2 5 5 5 2 WD40-like domain Kelch_6 PF13964.6 ETO26868.1 - 2.9e-06 27.3 1.3 0.093 13.1 0.1 4.4 4 0 0 4 4 3 1 Kelch motif SGL PF08450.12 ETO26868.1 - 0.00062 19.4 0.4 0.27 10.8 0.1 2.7 2 0 0 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 ETO26868.1 - 0.00092 19.3 0.0 19 5.4 0.0 4.2 3 1 0 3 3 3 0 Strictosidine synthase Kelch_4 PF13418.6 ETO26868.1 - 0.0031 17.5 0.0 0.019 15.0 0.0 2.4 2 0 0 2 2 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO26868.1 - 0.01 15.4 0.9 0.042 13.4 0.2 2.5 2 0 0 2 2 2 0 Kelch motif Ret2_MD PF18528.1 ETO26868.1 - 0.024 15.0 0.2 9.2 6.7 0.0 4.1 2 2 2 4 4 4 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Kelch_5 PF13854.6 ETO26868.1 - 0.061 13.3 3.3 1.4 9.0 0.8 3.6 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO26868.1 - 0.098 13.0 0.0 0.45 10.9 0.0 2.2 1 0 0 1 1 1 0 Galactose oxidase, central domain DUF3902 PF13042.6 ETO26868.1 - 0.11 12.0 2.8 0.28 10.7 2.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3902) Kelch_2 PF07646.15 ETO26868.1 - 0.14 12.2 2.0 10 6.3 0.1 3.9 3 0 0 3 3 3 0 Kelch motif PLD_C PF12357.8 ETO26868.1 - 0.46 10.4 1.7 20 5.2 0.0 4.3 4 2 1 5 5 5 0 Phospholipase D C terminal Proteasome_A_N PF10584.9 ETO26868.1 - 0.94 9.2 11.5 35 4.2 0.3 5.4 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Cpta_toxin PF07254.12 ETO26868.1 - 2 8.4 6.1 2.3 8.2 0.4 2.6 2 0 0 2 2 2 0 Membrane-bound toxin component of toxin-antitoxin system Ras PF00071.22 ETO26869.1 - 1.7e-11 44.0 0.2 2.5e-11 43.4 0.2 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO26869.1 - 0.038 14.2 0.0 0.079 13.2 0.0 1.5 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO26869.1 - 0.089 12.7 0.0 0.28 11.1 0.1 1.7 2 0 0 2 2 2 0 RsgA GTPase WD40 PF00400.32 ETO26870.1 - 4.2e-37 125.5 25.1 6.4e-06 26.8 0.0 7.3 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO26870.1 - 5e-15 55.1 4.7 0.021 13.5 0.1 6.2 2 1 4 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO26870.1 - 1.2e-13 51.1 1.2 0.1 12.9 0.0 5.9 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO26870.1 - 8.5e-08 32.8 3.8 3.4e-07 30.8 3.8 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger WD40_like PF17005.5 ETO26870.1 - 9.3e-05 21.9 1.4 0.38 10.0 0.1 3.9 4 1 0 4 4 4 2 WD40-like domain YabA PF06156.13 ETO26870.1 - 0.0023 18.5 1.7 0.0023 18.5 1.7 3.5 3 0 0 3 3 3 1 Initiation control protein YabA DivIC PF04977.15 ETO26870.1 - 0.33 10.8 17.4 0.36 10.6 3.1 3.0 2 0 0 2 2 2 0 Septum formation initiator HrpB7 PF09486.10 ETO26870.1 - 0.52 10.7 8.6 1.1 9.6 8.6 1.5 1 0 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) UPF0242 PF06785.11 ETO26870.1 - 0.54 10.3 30.8 0.37 10.9 11.2 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus zf-TRAF_2 PF15965.5 ETO26870.1 - 1.7 9.2 6.8 0.63 10.5 3.3 2.1 1 1 0 1 1 1 0 TRAF-like zinc-finger Fez1 PF06818.15 ETO26870.1 - 2.5 8.5 28.8 0.53 10.7 3.0 3.0 1 1 1 3 3 3 0 Fez1 AAA_lid_9 PF17871.1 ETO26870.1 - 9.6 6.2 12.9 17 5.4 0.0 3.7 3 1 0 3 3 3 0 AAA lid domain TPR_1 PF00515.28 ETO26871.1 - 6.6e-21 73.2 11.2 0.0011 18.7 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26871.1 - 3.4e-20 70.5 16.3 0.00011 22.1 0.3 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO26871.1 - 2.1e-17 61.8 22.2 2.2e-05 24.3 0.4 7.0 7 0 0 7 7 6 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO26871.1 - 5.6e-15 54.8 17.3 0.00019 21.1 0.3 5.7 3 1 2 5 5 5 4 TPR repeat TPR_12 PF13424.6 ETO26871.1 - 1.2e-13 51.1 10.7 0.00023 21.4 0.6 5.2 3 1 2 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO26871.1 - 4.2e-13 48.7 14.4 5.5e-05 23.3 0.8 6.9 6 1 0 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26871.1 - 1.7e-11 43.9 1.7 0.14 13.0 0.0 5.8 3 1 3 6 6 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO26871.1 - 1.6e-10 41.4 0.9 0.015 16.0 0.1 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat SAM_1 PF00536.30 ETO26871.1 - 2.9e-09 37.2 0.2 5.7e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_7 PF13176.6 ETO26871.1 - 8.8e-09 34.8 12.1 0.047 13.7 0.7 5.9 6 0 0 6 6 5 2 Tetratricopeptide repeat SAM_2 PF07647.17 ETO26871.1 - 1.1e-07 31.8 0.1 2.7e-07 30.6 0.1 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TPR_10 PF13374.6 ETO26871.1 - 4.9e-06 26.2 3.7 0.018 14.9 0.2 5.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO26871.1 - 6e-06 26.7 8.7 0.019 15.4 0.2 4.8 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO26871.1 - 0.0018 17.7 0.2 0.0083 15.5 0.2 2.2 2 1 0 2 2 2 1 MalT-like TPR region Mad3_BUB1_I PF08311.12 ETO26871.1 - 0.044 13.8 9.8 0.64 10.0 1.0 4.1 4 0 0 4 4 4 0 Mad3/BUB1 homology region 1 IGR PF09597.10 ETO26871.1 - 0.091 12.9 0.1 0.23 11.6 0.1 1.8 1 0 0 1 1 1 0 IGR protein motif MIT PF04212.18 ETO26871.1 - 0.76 9.9 11.7 18 5.5 0.1 5.8 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain SUIM_assoc PF16619.5 ETO26871.1 - 0.89 9.7 26.2 0.058 13.5 3.1 3.9 3 0 0 3 3 3 0 Unstructured region C-term to UIM in Ataxin3 Sel1 PF08238.12 ETO26871.1 - 1.1 10.0 6.4 57 4.6 0.0 4.1 4 0 0 4 4 3 0 Sel1 repeat TPR_1 PF00515.28 ETO26872.1 - 1.7e-05 24.4 0.3 3.1e-05 23.6 0.3 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO26872.1 - 0.00018 22.1 0.0 0.00034 21.2 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO26872.1 - 0.0016 18.4 0.1 0.0031 17.5 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat Suf PF05843.14 ETO26872.1 - 0.02 14.9 0.0 0.04 13.9 0.0 1.4 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) CHD5 PF04420.14 ETO26872.1 - 0.024 14.5 0.1 0.039 13.8 0.1 1.4 1 0 0 1 1 1 0 CHD5-like protein TPR_6 PF13174.6 ETO26872.1 - 0.043 14.4 0.0 0.085 13.5 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO26872.1 - 0.066 13.5 0.0 0.13 12.6 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO26872.1 - 0.14 12.2 0.1 0.25 11.4 0.1 1.4 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat Aa_trans PF01490.18 ETO26873.1 - 0.00023 20.0 0.1 0.00037 19.3 0.1 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein Pex24p PF06398.11 ETO26873.1 - 0.0032 16.5 0.5 0.0032 16.5 0.5 2.9 3 1 1 4 4 4 1 Integral peroxisomal membrane peroxin Baculo_11_kDa PF06143.11 ETO26873.1 - 0.014 15.0 1.1 0.07 12.7 1.1 2.2 1 0 0 1 1 1 0 Baculovirus 11 kDa family ArsP_1 PF03773.13 ETO26873.1 - 0.017 14.3 0.1 0.046 12.9 0.1 1.8 1 0 0 1 1 1 0 Predicted permease Sm_multidrug_ex PF06695.11 ETO26873.1 - 0.23 12.1 0.2 1.3 9.6 0.2 2.3 1 0 0 1 1 1 0 Putative small multi-drug export protein OTT_1508_deam PF14441.6 ETO26873.1 - 0.33 11.0 11.2 0.044 13.8 1.0 3.0 2 1 0 2 2 2 0 OTT_1508-like deaminase Hydantoinase_B PF02538.14 ETO26873.1 - 0.45 8.9 1.9 0.76 8.1 1.9 1.2 1 0 0 1 1 1 0 Hydantoinase B/oxoprolinase GWT1 PF06423.12 ETO26873.1 - 0.64 10.1 6.7 0.32 11.1 2.1 2.7 2 1 0 2 2 2 0 GWT1 ATC_hydrolase PF14196.6 ETO26874.1 - 0.7 10.7 5.2 0.36 11.6 1.6 2.1 2 0 0 2 2 2 0 L-2-amino-thiazoline-4-carboxylic acid hydrolase PTH2 PF01981.16 ETO26875.1 - 9.2e-13 48.5 0.0 2.2e-12 47.3 0.0 1.6 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 UBA PF00627.31 ETO26875.1 - 0.00013 21.8 0.2 0.0017 18.2 0.2 2.5 1 1 0 1 1 1 1 UBA/TS-N domain FtsJ PF01728.19 ETO26876.1 - 6.9e-07 29.5 0.1 1.4e-06 28.5 0.1 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase TMEM51 PF15345.6 ETO26876.1 - 0.25 11.2 2.1 9.5 6.0 0.0 2.5 1 1 1 2 2 2 0 Transmembrane protein 51 FtsJ PF01728.19 ETO26877.1 - 1.1e-37 129.8 0.3 2.1e-37 129.0 0.0 1.5 2 0 0 2 2 2 1 FtsJ-like methyltransferase Methyltr_RsmB-F PF01189.17 ETO26877.1 - 0.062 12.9 0.0 0.099 12.3 0.0 1.2 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Pkinase PF00069.25 ETO26878.1 - 2.6e-30 105.7 0.4 5.1e-30 104.7 0.4 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26878.1 - 5.5e-08 32.4 0.6 9.5e-07 28.3 0.1 2.4 2 1 0 2 2 2 1 Protein tyrosine kinase Beta-lactamase PF00144.24 ETO26879.1 - 2.1e-06 27.2 0.0 2.9e-06 26.8 0.0 1.1 1 0 0 1 1 1 1 Beta-lactamase GTP_EFTU PF00009.27 ETO26880.1 - 4e-44 150.5 0.0 8.2e-44 149.5 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETO26880.1 - 1e-09 38.6 0.0 1e-09 38.6 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETO26880.1 - 1.1e-06 28.9 0.1 3.5e-05 24.1 0.0 2.6 2 0 0 2 2 2 1 Elongation factor Tu domain 2 MMR_HSR1 PF01926.23 ETO26880.1 - 0.0026 17.8 0.2 0.017 15.2 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Band_3_cyto PF07565.13 ETO26880.1 - 0.18 11.5 3.4 0.31 10.8 3.4 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MCM_bind PF09739.9 ETO26880.1 - 4 5.8 9.6 5.6 5.3 9.6 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor ABC_membrane PF00664.23 ETO26882.1 - 5.6e-36 124.6 3.6 7.1e-36 124.3 3.6 1.0 1 0 0 1 1 1 1 ABC transporter transmembrane region DUF3397 PF11877.8 ETO26882.1 - 0.046 13.9 0.3 0.046 13.9 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3397) PolyA_pol PF01743.20 ETO26883.1 - 5.1e-21 75.4 0.0 1.2e-20 74.3 0.0 1.6 2 0 0 2 2 2 1 Poly A polymerase head domain Colicin_im PF03857.13 ETO26883.1 - 0.013 15.5 2.9 0.02 14.8 2.9 1.2 1 0 0 1 1 1 0 Colicin immunity protein VPS9 PF02204.18 ETO26884.1 - 5.9e-11 42.5 0.0 1.7e-09 37.8 0.0 2.6 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain HECA PF15353.6 ETO26885.1 - 0.026 14.7 0.5 0.48 10.7 0.1 2.5 2 0 0 2 2 2 0 Headcase protein family homologue SUIM_assoc PF16619.5 ETO26886.1 - 0.0019 18.2 1.5 0.0028 17.7 1.5 1.4 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Nup188_C PF18378.1 ETO26886.1 - 0.033 13.0 0.1 0.043 12.7 0.1 1.1 1 0 0 1 1 1 0 Nuclear pore protein NUP188 C-terminal domain RasGEF_N PF00618.20 ETO26886.1 - 0.096 12.9 0.5 0.16 12.2 0.5 1.3 1 0 0 1 1 1 0 RasGEF N-terminal motif CorC_HlyC PF03471.17 ETO26887.1 - 2.7e-23 81.8 0.9 1.2e-21 76.4 0.1 2.3 2 1 0 2 2 2 1 Transporter associated domain CBS PF00571.28 ETO26887.1 - 4.7e-05 23.7 0.1 0.00013 22.4 0.0 1.8 2 0 0 2 2 2 1 CBS domain DUF5030 PF16433.5 ETO26887.1 - 0.029 13.7 0.0 0.04 13.2 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5030) Staph_opine_DH PF10100.9 ETO26887.1 - 0.098 11.3 0.1 0.15 10.6 0.0 1.3 2 0 0 2 2 2 0 Staphylopine dehydrogenase SR-25 PF10500.9 ETO26888.1 - 0.00013 21.6 10.4 0.00013 21.6 10.4 5.0 6 1 0 6 6 6 2 Nuclear RNA-splicing-associated protein LANC_like PF05147.13 ETO26890.1 - 3.6e-12 45.5 0.1 4.1e-12 45.4 0.1 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein CxC5 PF18718.1 ETO26890.1 - 1.1 9.3 6.4 2.2 8.4 0.6 2.4 2 1 0 2 2 2 0 CxC5 like cysteine cluster associated with KDZ transposases Band_7 PF01145.25 ETO26891.1 - 0.0039 17.2 0.4 0.0074 16.3 0.2 1.6 1 1 0 1 1 1 1 SPFH domain / Band 7 family HTH_41 PF14502.6 ETO26891.1 - 0.068 12.9 0.2 3.9 7.2 0.0 2.6 2 0 0 2 2 2 0 Helix-turn-helix domain Kelch_4 PF13418.6 ETO26892.1 - 1.6e-10 40.8 0.6 1.8e-07 31.1 0.2 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO26892.1 - 9.9e-08 31.4 0.2 0.0005 19.6 0.0 2.6 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO26892.1 - 1.3e-07 31.7 0.7 0.0046 17.2 0.2 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO26892.1 - 1e-06 28.9 0.9 5.2e-05 23.4 0.3 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO26892.1 - 0.00011 22.1 0.3 0.00026 20.9 0.2 1.7 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO26892.1 - 0.0013 18.7 0.2 0.07 13.1 0.3 2.7 2 1 0 2 2 2 1 Kelch motif WSK PF03832.13 ETO26893.1 - 2.1 8.1 8.6 0.13 11.9 2.6 2.0 2 0 0 2 2 2 0 WSK motif DUF3108 PF11306.8 ETO26894.1 - 0.019 15.0 0.2 0.019 14.9 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3108) UPF0240 PF06784.11 ETO26894.1 - 0.024 14.7 0.1 0.032 14.3 0.1 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0240) La PF05383.17 ETO26895.1 - 3.9e-15 55.6 0.0 9.7e-15 54.4 0.0 1.7 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ETO26895.1 - 2.4e-06 27.3 0.0 0.029 14.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DrsE PF02635.15 ETO26896.1 - 0.04 14.3 0.3 0.083 13.3 0.2 1.5 1 1 0 1 1 1 0 DsrE/DsrF-like family Presenilin PF01080.17 ETO26896.1 - 0.97 8.1 2.0 1.1 8.0 2.0 1.1 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO26896.1 - 2.4 7.3 3.5 2.9 7.0 3.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DAO PF01266.24 ETO26897.1 - 2.5e-40 139.1 0.0 4.4e-40 138.3 0.0 1.3 1 0 0 1 1 1 1 FAD dependent oxidoreductase DAO_C PF16901.5 ETO26897.1 - 6.1e-34 116.6 0.1 1.3e-33 115.5 0.1 1.6 1 0 0 1 1 1 1 C-terminal domain of alpha-glycerophosphate oxidase FAD_binding_2 PF00890.24 ETO26897.1 - 0.002 17.3 1.5 0.0044 16.2 1.5 1.5 1 0 0 1 1 1 1 FAD binding domain FAD_binding_3 PF01494.19 ETO26897.1 - 0.044 13.0 0.3 0.091 12.0 0.3 1.5 1 0 0 1 1 1 0 FAD binding domain FAD_oxidored PF12831.7 ETO26897.1 - 0.067 12.5 1.7 0.22 10.8 1.7 1.9 1 0 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO26897.1 - 0.078 12.2 0.1 0.17 11.1 0.1 1.5 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO26897.1 - 0.26 11.6 1.7 0.71 10.2 1.7 1.8 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain 3HCDH_N PF02737.18 ETO26897.1 - 0.3 11.0 2.8 0.23 11.3 0.1 2.2 2 0 0 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain HI0933_like PF03486.14 ETO26897.1 - 5.7 5.5 6.9 0.22 10.2 0.8 1.6 2 0 0 2 2 2 0 HI0933-like protein Sulfatase PF00884.23 ETO26898.1 - 9.7e-37 127.0 2.3 1e-35 123.7 2.3 2.1 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ETO26898.1 - 1.7e-05 24.6 1.6 0.0001 22.0 1.6 2.1 1 1 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase RGS PF00615.19 ETO26899.1 - 5.5e-08 33.1 0.1 1.6e-07 31.6 0.1 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain RNA_pol PF00940.19 ETO26899.1 - 0.017 14.0 0.2 0.027 13.3 0.2 1.2 1 0 0 1 1 1 0 DNA-dependent RNA polymerase ICMT PF04140.14 ETO26899.1 - 0.68 10.4 5.8 0.19 12.1 1.9 2.1 2 0 0 2 2 2 0 Isoprenylcysteine carboxyl methyltransferase (ICMT) family Rota_NS6 PF04866.12 ETO26899.1 - 0.87 9.8 4.5 4 7.7 0.1 2.7 2 0 0 2 2 2 0 Rotavirus non-structural protein 6 GGACT PF06094.12 ETO26900.1 - 4.6e-06 27.2 0.0 5.8e-06 26.9 0.0 1.2 1 0 0 1 1 1 1 Gamma-glutamyl cyclotransferase, AIG2-like AIG2_2 PF13772.6 ETO26900.1 - 0.0071 16.7 0.0 0.012 16.0 0.0 1.4 1 0 0 1 1 1 1 AIG2-like family GATase PF00117.28 ETO26901.1 - 1.4e-13 51.0 3.1 2.2e-13 50.4 0.0 2.5 1 1 1 2 2 2 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO26901.1 - 4.1e-05 23.4 0.0 4.1e-05 23.4 0.0 2.0 2 0 0 2 2 2 1 Peptidase C26 DJ-1_PfpI PF01965.24 ETO26901.1 - 0.0066 16.3 0.0 0.014 15.2 0.0 1.6 1 0 0 1 1 1 1 DJ-1/PfpI family Dsh_C PF12316.8 ETO26901.1 - 0.38 11.1 5.1 0.66 10.3 5.1 1.5 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Macoilin PF09726.9 ETO26901.1 - 1.6 7.2 18.4 2 6.9 18.4 1.1 1 0 0 1 1 1 0 Macoilin family SOBP PF15279.6 ETO26901.1 - 5.5 7.5 15.9 9.8 6.7 15.9 1.3 1 0 0 1 1 1 0 Sine oculis-binding protein Pkinase PF00069.25 ETO26902.1 - 8.6e-16 58.1 7.1 1.4e-15 57.4 7.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26902.1 - 5.7e-05 22.5 3.4 9.1e-05 21.9 3.4 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3087 PF11286.8 ETO26903.1 - 0.0064 16.0 0.1 0.013 15.0 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3087) dNK PF01712.19 ETO26904.1 - 8e-25 87.9 0.2 1.4e-16 60.9 0.0 2.3 2 0 0 2 2 2 2 Deoxynucleoside kinase AAA_33 PF13671.6 ETO26904.1 - 1.9e-05 24.9 0.0 0.00021 21.5 0.0 2.5 1 1 1 2 2 2 1 AAA domain AAA_28 PF13521.6 ETO26904.1 - 0.00016 22.0 0.0 0.035 14.4 0.0 2.3 2 0 0 2 2 2 2 AAA domain Thymidylate_kin PF02223.17 ETO26904.1 - 0.00089 19.0 0.0 0.0026 17.5 0.0 1.8 2 0 0 2 2 2 1 Thymidylate kinase AAA_18 PF13238.6 ETO26904.1 - 0.0028 18.2 1.3 0.23 12.0 0.3 3.2 1 1 1 2 2 2 1 AAA domain Cullin PF00888.22 ETO26905.1 - 6.9e-62 209.9 10.4 8.4e-62 209.6 10.4 1.0 1 0 0 1 1 1 1 Cullin family Cullin_Nedd8 PF10557.9 ETO26906.1 - 1.6e-25 88.9 4.1 2.8e-25 88.1 4.1 1.4 1 0 0 1 1 1 1 Cullin protein neddylation domain Cullin PF00888.22 ETO26906.1 - 2.3e-14 53.0 7.0 2.3e-14 53.0 0.3 2.0 2 0 0 2 2 2 2 Cullin family DSPc PF00782.20 ETO26907.1 - 3.3e-19 69.0 0.1 3.3e-19 69.0 0.1 2.4 1 1 1 2 2 2 1 Dual specificity phosphatase, catalytic domain LAMTOR5 PF16672.5 ETO26907.1 - 0.085 12.8 0.5 0.27 11.2 0.5 1.8 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 Radial_spoke PF04712.12 ETO26908.1 - 0.016 14.2 1.1 0.51 9.2 0.1 2.1 2 0 0 2 2 2 0 Radial spokehead-like protein SID-1_RNA_chan PF13965.6 ETO26908.1 - 0.25 9.7 1.3 0.38 9.1 1.3 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 TFIIA_gamma_N PF02268.16 ETO26909.1 - 1.6e-14 53.6 0.0 2.2e-14 53.2 0.0 1.2 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit, helical domain TFIIA_gamma_C PF02751.14 ETO26909.1 - 3.4e-11 43.1 0.0 5.9e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Transcription initiation factor IIA, gamma subunit TFCD_C PF12612.8 ETO26910.1 - 0.00012 22.0 0.2 0.00023 21.1 0.2 1.5 1 0 0 1 1 1 1 Tubulin folding cofactor D C terminal DUF1885 PF08968.10 ETO26910.1 - 0.0082 16.2 0.1 0.018 15.1 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1885) CSRNP_N PF16019.5 ETO26911.1 - 0.058 13.3 2.7 0.12 12.3 1.5 2.1 1 1 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus JIP_LZII PF16471.5 ETO26912.1 - 0.087 13.0 0.2 0.087 13.0 0.2 5.3 4 2 1 5 5 5 0 JNK-interacting protein leucine zipper II NTP_transf_4 PF13562.6 ETO26913.1 - 0.0009 19.5 3.1 0.085 13.1 0.1 3.2 3 0 0 3 3 3 1 Sugar nucleotidyl transferase PBECR3 PF18812.1 ETO26913.1 - 0.041 13.8 0.1 0.15 12.0 0.1 2.0 1 0 0 1 1 1 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease3 Gar1 PF04410.14 ETO26913.1 - 0.084 12.6 0.3 0.24 11.1 0.3 1.8 1 0 0 1 1 1 0 Gar1/Naf1 RNA binding region Lzipper-MIP1 PF14389.6 ETO26913.1 - 0.1 12.9 2.6 0.16 12.3 1.0 2.3 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 PhoU PF01895.19 ETO26913.1 - 0.28 11.7 1.5 7 7.2 0.1 3.3 3 0 0 3 3 3 0 PhoU domain DUF4735 PF15882.5 ETO26913.1 - 1.3 8.4 9.0 0.25 10.7 1.5 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4735) WD40 PF00400.32 ETO26914.1 - 0.00044 21.0 1.9 7.6 7.6 0.0 4.3 4 0 0 4 4 4 2 WD domain, G-beta repeat Kelch_6 PF13964.6 ETO26914.1 - 0.017 15.4 0.1 0.17 12.3 0.0 2.6 3 0 0 3 3 3 0 Kelch motif Cadherin_C_2 PF16492.5 ETO26915.1 - 0.19 12.5 0.5 0.19 12.5 0.5 2.0 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal COX16 PF14138.6 ETO26915.1 - 3.1 8.4 5.1 6.1 7.4 0.5 2.5 3 0 0 3 3 3 0 Cytochrome c oxidase assembly protein COX16 DUF2956 PF11169.8 ETO26916.1 - 3.1 8.0 0.0 3.1 8.0 0.0 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2956) Ribosomal_S8 PF00410.19 ETO26917.1 - 5.2e-14 52.3 0.1 9.1e-12 45.0 0.1 2.3 1 1 0 1 1 1 1 Ribosomal protein S8 PND PF17949.1 ETO26917.1 - 0.077 13.2 2.1 3.6 7.9 0.4 2.2 1 1 1 2 2 2 0 FANCM pseudonuclease domain APG6_N PF17675.1 ETO26918.1 - 0.023 15.2 8.5 0.023 15.2 8.5 3.6 4 0 0 4 4 4 0 Apg6 coiled-coil region DltD PF04914.12 ETO26919.1 - 0.013 14.9 2.2 0.015 14.7 2.2 1.0 1 0 0 1 1 1 0 DltD protein NBD94 PF16830.5 ETO26919.1 - 0.058 13.8 4.7 0.047 14.1 2.8 1.8 1 1 0 1 1 1 0 Nucleotide-Binding Domain 94 of RH GlutR_dimer PF00745.20 ETO26919.1 - 0.095 13.2 2.5 0.14 12.6 2.5 1.2 1 0 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain SNAPc19 PF15497.6 ETO26919.1 - 0.16 12.5 9.0 0.25 11.8 0.3 2.4 2 1 0 2 2 2 0 snRNA-activating protein complex subunit 19, SNAPc subunit 19 RNase_HII PF01351.18 ETO26919.1 - 0.33 10.8 2.6 0.38 10.6 2.6 1.2 1 0 0 1 1 1 0 Ribonuclease HII YabA PF06156.13 ETO26919.1 - 4.6 7.9 8.6 2 9.1 3.5 2.1 1 1 0 2 2 2 0 Initiation control protein YabA DDRGK PF09756.9 ETO26922.1 - 0.0081 15.8 11.6 0.01 15.5 11.6 1.1 1 0 0 1 1 1 1 DDRGK domain Fmp27 PF10344.9 ETO26922.1 - 0.035 12.2 3.4 0.041 12.0 3.4 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 Connexin PF00029.19 ETO26922.1 - 0.041 13.6 0.5 0.037 13.8 0.5 1.2 1 0 0 1 1 1 0 Connexin ORC_WH_C PF18137.1 ETO26922.1 - 0.078 13.1 4.6 0.1 12.6 4.6 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DDHD PF02862.17 ETO26922.1 - 0.098 12.8 0.8 0.099 12.8 0.8 1.1 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO26922.1 - 0.13 11.1 1.1 0.12 11.2 1.1 1.1 1 0 0 1 1 1 0 Presenilin RPA43_OB PF17875.1 ETO26922.1 - 0.15 12.7 3.3 0.21 12.2 3.3 1.1 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Sec62 PF03839.16 ETO26922.1 - 0.16 11.5 1.6 0.16 11.5 1.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 EIIBC-GUT_N PF03612.14 ETO26922.1 - 0.22 11.2 3.9 0.26 11.0 3.9 1.2 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Atrophin-1 PF03154.15 ETO26922.1 - 0.76 8.0 6.4 0.87 7.8 6.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family PTPRCAP PF15713.5 ETO26922.1 - 0.84 9.9 10.0 1 9.6 10.0 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CobT PF06213.12 ETO26922.1 - 0.87 8.9 9.6 1 8.7 9.6 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 ETO26922.1 - 1.3 7.2 8.7 1.6 6.9 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.11 ETO26922.1 - 1.4 8.9 4.3 2 8.4 4.3 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) GNAT_acetyltr_2 PF13718.6 ETO26922.1 - 1.9 7.8 5.6 2.3 7.5 5.6 1.1 1 0 0 1 1 1 0 GNAT acetyltransferase 2 FAM176 PF14851.6 ETO26922.1 - 2 8.0 8.0 3.2 7.4 8.0 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO26922.1 - 4.5 6.5 9.7 6.4 6.0 9.7 1.2 1 0 0 1 1 1 0 NOA36 protein DUF3464 PF11947.8 ETO26922.1 - 9.5 6.0 7.0 13 5.5 7.0 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 P-mevalo_kinase PF04275.14 ETO26923.1 - 0.022 14.7 0.9 0.06 13.3 0.0 2.1 2 1 0 2 2 2 0 Phosphomevalonate kinase MDFI PF15316.6 ETO26923.1 - 1.5 8.9 6.5 0.42 10.7 1.4 2.1 2 0 0 2 2 2 0 MyoD family inhibitor CAF1C_H4-bd PF12265.8 ETO26924.1 - 0.00022 21.4 0.3 0.0006 20.0 0.2 1.9 2 0 0 2 2 2 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex SPATA3 PF15662.5 ETO26924.1 - 0.0067 17.1 2.7 0.011 16.4 2.7 1.3 1 0 0 1 1 1 1 Spermatogenesis-associated protein 3 family BAF1_ABF1 PF04684.13 ETO26924.1 - 0.013 14.6 15.0 0.017 14.2 15.0 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor Menin PF05053.13 ETO26924.1 - 0.091 11.1 11.9 0.12 10.7 11.9 1.2 1 0 0 1 1 1 0 Menin CPSF100_C PF13299.6 ETO26924.1 - 0.1 12.7 5.0 0.15 12.2 5.0 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF3439 PF11921.8 ETO26924.1 - 0.32 11.0 2.7 0.77 9.7 2.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Macoilin PF09726.9 ETO26924.1 - 0.4 9.2 9.8 0.5 8.9 9.8 1.1 1 0 0 1 1 1 0 Macoilin family DUF1754 PF08555.10 ETO26924.1 - 8.6 7.2 10.0 16 6.4 10.0 1.4 1 0 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) ArsA_ATPase PF02374.15 ETO26925.1 - 1.1e-68 231.6 0.1 1.4e-68 231.3 0.1 1.1 1 0 0 1 1 1 1 Anion-transporting ATPase FlaC_arch PF05377.11 ETO26925.1 - 3.5 8.1 5.7 0.77 10.2 0.9 2.5 3 1 0 3 3 3 0 Flagella accessory protein C (FlaC) Nop14 PF04147.12 ETO26927.1 - 0.23 9.6 12.3 0.25 9.5 12.3 1.0 1 0 0 1 1 1 0 Nop14-like family MAJIN PF15077.6 ETO26927.1 - 0.45 10.3 2.7 0.61 9.8 2.7 1.1 1 0 0 1 1 1 0 Membrane-anchored junction protein GEN1_C PF18380.1 ETO26927.1 - 0.88 10.5 10.0 0.22 12.4 5.1 2.0 1 1 1 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Presenilin PF01080.17 ETO26927.1 - 1.9 7.2 6.9 2.3 6.9 6.9 1.1 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO26927.1 - 6.5 6.0 13.9 8 5.7 13.9 1.2 1 0 0 1 1 1 0 NOA36 protein NPR3 PF03666.13 ETO26927.1 - 6.6 5.4 9.0 8 5.1 9.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CAP_GLY PF01302.25 ETO26929.1 - 0.00069 19.6 0.0 0.0014 18.6 0.0 1.5 1 0 0 1 1 1 1 CAP-Gly domain Cortex-I_coil PF09304.10 ETO26929.1 - 0.12 12.6 2.0 5.1 7.4 0.3 3.0 3 0 0 3 3 3 0 Cortexillin I, coiled coil Unstab_antitox PF09720.10 ETO26929.1 - 0.15 12.2 1.8 46 4.2 2.0 3.2 3 0 0 3 3 3 0 Putative addiction module component SID-1_RNA_chan PF13965.6 ETO26929.1 - 0.24 9.8 1.4 0.3 9.5 1.4 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ATG16 PF08614.11 ETO26929.1 - 4.9 7.3 10.7 3.1 8.0 2.9 2.4 2 1 0 2 2 2 0 Autophagy protein 16 (ATG16) RHD3 PF05879.12 ETO26930.1 - 7.4e-77 259.2 29.8 3.7e-32 111.4 14.9 5.1 2 1 2 4 4 4 4 Root hair defective 3 GTP-binding protein (RHD3) Spo0A_C PF08769.11 ETO26930.1 - 0.061 13.4 0.2 0.68 10.1 0.1 2.6 2 0 0 2 2 2 0 Sporulation initiation factor Spo0A C terminal CTD_bind PF04818.13 ETO26930.1 - 1.4 9.8 5.3 5.2 8.0 0.0 3.7 3 1 0 3 3 3 0 RNA polymerase II-binding domain. EamA PF00892.20 ETO26931.1 - 5.1e-12 46.1 32.2 8.6e-10 38.9 17.7 2.1 1 1 1 2 2 2 2 EamA-like transporter family DUF3963 PF13124.6 ETO26931.1 - 0.04 13.9 3.9 0.83 9.7 0.4 2.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3963) EamA PF00892.20 ETO26932.1 - 0.006 16.7 1.2 0.011 15.9 0.2 1.7 2 0 0 2 2 2 1 EamA-like transporter family DUF983 PF06170.12 ETO26933.1 - 1.2 9.6 5.4 6.4 7.3 5.8 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF983) ANAPC4_WD40 PF12894.7 ETO26935.1 - 0.051 13.9 0.1 4.7 7.6 0.0 3.1 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PHD PF00628.29 ETO26936.1 - 1.5e-08 34.4 9.5 1.5e-08 34.4 9.5 2.3 2 0 0 2 2 2 1 PHD-finger SLED PF12140.8 ETO26938.1 - 1.4 9.5 6.0 0.95 10.0 0.2 3.0 2 1 0 2 2 2 0 SLED domain Bromo_coat PF01318.18 ETO26939.1 - 0.15 12.1 0.1 0.23 11.5 0.1 1.2 1 0 0 1 1 1 0 Bromovirus coat protein Phospholamban PF04272.14 ETO26939.1 - 0.31 10.6 3.5 0.16 11.5 0.7 1.9 2 0 0 2 2 2 0 Phospholamban PilZ_2 PF16823.5 ETO26940.1 - 0.2 11.8 0.0 0.46 10.6 0.0 1.6 2 0 0 2 2 2 0 Atypical PilZ domain, cyclic di-GMP receptor zinc_ribbon_4 PF13717.6 ETO26941.1 - 0.032 14.1 1.2 5.3 7.1 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain TMEM51 PF15345.6 ETO26941.1 - 0.043 13.6 13.3 0.095 12.5 13.3 1.5 1 0 0 1 1 1 0 Transmembrane protein 51 FAM91_C PF14648.6 ETO26941.1 - 0.12 11.2 5.2 0.19 10.5 5.2 1.3 1 0 0 1 1 1 0 FAM91 C-terminus SpoIIP PF07454.11 ETO26941.1 - 0.15 11.5 12.0 0.26 10.7 12.0 1.3 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CPSF100_C PF13299.6 ETO26941.1 - 0.17 12.1 9.8 0.45 10.7 9.8 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Ndc1_Nup PF09531.10 ETO26941.1 - 0.19 10.4 5.3 0.23 10.1 5.3 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CobT PF06213.12 ETO26941.1 - 0.29 10.5 17.2 0.45 9.8 17.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF3408 PF11888.8 ETO26941.1 - 0.38 10.9 18.0 0.73 10.0 14.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3408) Presenilin PF01080.17 ETO26941.1 - 0.4 9.4 13.9 0.63 8.7 13.9 1.3 1 0 0 1 1 1 0 Presenilin DUF4746 PF15928.5 ETO26941.1 - 0.45 9.9 10.4 3 7.2 8.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) eIF-3_zeta PF05091.12 ETO26941.1 - 0.6 9.0 16.2 0.93 8.4 16.2 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RR_TM4-6 PF06459.12 ETO26941.1 - 0.68 9.7 15.3 1.2 8.9 15.3 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4175 PF13779.6 ETO26941.1 - 0.71 7.7 26.6 1 7.2 26.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Zip PF02535.22 ETO26941.1 - 1.5 8.0 2.8 2.5 7.3 2.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 ETO26941.1 - 1.8 7.4 4.8 2.7 6.8 4.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 ETO26941.1 - 1.9 7.4 8.9 3.2 6.7 8.9 1.3 1 0 0 1 1 1 0 CLN3 protein TFB6 PF17110.5 ETO26941.1 - 2 8.1 8.0 3.7 7.3 8.0 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Serinc PF03348.15 ETO26941.1 - 2.2 7.1 7.5 3.9 6.3 7.5 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Membralin PF09746.9 ETO26941.1 - 2.2 7.2 6.4 4.5 6.2 6.4 1.5 1 0 0 1 1 1 0 Tumour-associated protein zf-C2H2 PF00096.26 ETO26941.1 - 3.1 8.4 10.2 1.8 9.2 0.6 4.0 3 0 0 3 3 3 0 Zinc finger, C2H2 type EIIBC-GUT_N PF03612.14 ETO26941.1 - 4.1 7.1 10.7 8 6.2 10.7 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus V_ATPase_I PF01496.19 ETO26941.1 - 5.3 4.8 14.0 8.1 4.2 14.0 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family EOS1 PF12326.8 ETO26941.1 - 6.5 6.7 7.4 16 5.4 7.4 1.6 1 0 0 1 1 1 0 N-glycosylation protein Sec62 PF03839.16 ETO26941.1 - 7.4 6.0 11.9 15 5.0 11.9 1.5 1 0 0 1 1 1 0 Translocation protein Sec62 AIF_C PF14721.6 ETO26941.1 - 7.6 6.9 10.5 21 5.4 10.5 1.7 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Folate_carrier PF01770.18 ETO26941.1 - 8.7 5.0 8.1 14 4.3 8.1 1.2 1 0 0 1 1 1 0 Reduced folate carrier Nop14 PF04147.12 ETO26943.1 - 8e-05 21.1 7.2 0.0001 20.7 7.2 1.1 1 0 0 1 1 1 1 Nop14-like family Glyco_transf_49 PF13896.6 ETO26943.1 - 0.0032 16.9 0.0 0.013 14.9 0.0 2.1 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan BSP_II PF05432.11 ETO26943.1 - 0.04 13.6 21.6 0.063 13.0 21.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) ETRAMP PF09716.10 ETO26943.1 - 0.057 13.5 0.0 0.42 10.7 0.0 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Viral_Beta_CD PF04530.12 ETO26943.1 - 0.086 13.1 1.0 0.18 12.1 1.0 1.5 1 0 0 1 1 1 0 Viral Beta C/D like family CrgA PF06781.12 ETO26943.1 - 0.11 12.6 1.7 0.17 11.9 0.2 2.1 2 0 0 2 2 2 0 Cell division protein CrgA DUF4512 PF14975.6 ETO26943.1 - 0.13 13.1 1.7 0.28 12.0 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4512) Zip PF02535.22 ETO26943.1 - 0.28 10.4 1.6 0.42 9.8 1.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Trypan_PARP PF05887.11 ETO26943.1 - 0.54 10.2 7.3 0.87 9.6 7.3 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PTPRCAP PF15713.5 ETO26943.1 - 0.87 9.9 12.8 1.5 9.1 12.8 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated SDA1 PF05285.12 ETO26943.1 - 1.1 8.6 17.6 1.7 8.0 17.6 1.2 1 0 0 1 1 1 0 SDA1 Sporozoite_P67 PF05642.11 ETO26943.1 - 1.6 6.7 10.2 2.2 6.2 10.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4746 PF15928.5 ETO26943.1 - 2.4 7.5 12.6 3.3 7.1 11.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF3504 PF12012.8 ETO26948.1 - 0.0075 16.2 0.4 0.012 15.5 0.4 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3504) DUF4692 PF15763.5 ETO26948.1 - 0.0096 16.4 0.1 0.014 15.9 0.1 1.2 1 0 0 1 1 1 1 Regulator of human erythroid cell expansion (RHEX) DUF2304 PF10066.9 ETO26948.1 - 0.11 12.7 4.1 7.9 6.8 0.4 2.9 2 1 1 3 3 3 0 Uncharacterized conserved protein (DUF2304) Pox_Ag35 PF03286.14 ETO26948.1 - 0.16 11.8 9.5 0.21 11.3 9.5 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PBP1_TM PF14812.6 ETO26948.1 - 0.54 10.7 8.7 1.1 9.6 8.7 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2031 PF09592.10 ETO26949.1 - 0.092 12.2 0.9 0.17 11.4 0.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2031) Spem1 PF15670.5 ETO26949.1 - 0.6 9.7 8.5 0.042 13.4 2.4 1.9 2 0 0 2 2 2 0 Spermatid maturation protein 1 DUF572 PF04502.13 ETO26949.1 - 0.69 9.5 10.2 1.5 8.4 2.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) SCIMP PF15050.6 ETO26950.1 - 0.28 11.6 0.1 0.28 11.6 0.1 2.5 2 1 1 3 3 3 0 SCIMP protein Pkinase PF00069.25 ETO26951.1 - 5e-59 199.8 0.0 7.6e-59 199.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO26951.1 - 5.3e-25 88.2 0.0 7.3e-25 87.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO26951.1 - 2.6e-06 27.0 0.1 5.1e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 Kinase-like Seadorna_VP7 PF07387.11 ETO26951.1 - 0.036 13.1 0.0 0.06 12.4 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 cNMP_binding PF00027.29 ETO26953.1 - 1.1e-06 28.5 0.0 1.8e-06 28.0 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF4640 PF15480.6 ETO26953.1 - 0.039 13.7 0.1 0.044 13.5 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) dUTPase PF00692.19 ETO26954.1 - 6.7e-37 126.0 0.1 2e-25 88.9 0.0 2.1 2 0 0 2 2 2 2 dUTPase zf-RING_2 PF13639.6 ETO26955.1 - 1.6e-09 38.0 9.2 1.6e-09 38.0 9.2 3.9 2 1 1 3 3 2 1 Ring finger domain zf-RING_11 PF17123.5 ETO26955.1 - 4.9e-07 29.4 5.2 4.9e-07 29.4 5.2 3.8 4 0 0 4 4 4 2 RING-like zinc finger zf-C3HC4 PF00097.25 ETO26955.1 - 5.9e-07 29.3 9.0 5.9e-07 29.3 9.0 3.2 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO26955.1 - 5.4e-05 23.4 7.3 5.4e-05 23.4 7.3 4.2 3 2 0 3 3 3 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETO26955.1 - 0.00021 21.1 7.8 0.00021 21.1 7.8 3.9 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO26955.1 - 0.0095 16.0 1.7 0.0095 16.0 1.7 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETO26955.1 - 0.0098 15.5 25.3 0.031 13.9 5.0 3.8 2 1 1 3 3 3 2 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 ETO26955.1 - 0.02 14.8 9.1 0.02 14.8 9.1 2.9 2 1 0 2 2 2 0 zinc-RING finger domain YdjO PF14169.6 ETO26955.1 - 0.5 10.1 5.0 0.48 10.2 0.9 2.9 2 0 0 2 2 2 0 Cold-inducible protein YdjO PHD PF00628.29 ETO26955.1 - 0.84 9.6 30.4 1.2 9.1 6.5 4.3 2 1 1 3 3 3 0 PHD-finger Folate_carrier PF01770.18 ETO26955.1 - 1.8 7.2 4.4 12 4.5 1.1 2.4 2 0 0 2 2 2 0 Reduced folate carrier Zn-ribbon_8 PF09723.10 ETO26955.1 - 8.8 6.5 9.7 12 6.1 0.2 3.7 3 0 0 3 3 3 0 Zinc ribbon domain zf-HC5HC2H_2 PF13832.6 ETO26955.1 - 8.9 6.5 24.1 0.1 12.8 3.2 3.7 2 1 0 3 3 3 0 PHD-zinc-finger like domain PH_12 PF16457.5 ETO26956.1 - 0.02 15.4 0.4 0.045 14.3 0.0 1.7 2 0 0 2 2 2 0 Pleckstrin homology domain zf-RING_2 PF13639.6 ETO26957.1 - 1.6e-09 37.9 9.2 1.6e-09 37.9 9.2 3.6 2 1 1 3 3 2 1 Ring finger domain zf-RING_11 PF17123.5 ETO26957.1 - 5.1e-07 29.3 5.2 5.1e-07 29.3 5.2 3.8 4 0 0 4 4 4 2 RING-like zinc finger zf-C3HC4 PF00097.25 ETO26957.1 - 6.2e-07 29.2 9.0 6.2e-07 29.2 9.0 3.0 2 1 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO26957.1 - 5.8e-05 23.3 7.3 5.8e-05 23.3 7.3 3.4 2 2 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETO26957.1 - 0.00022 21.0 7.8 0.00022 21.0 7.8 3.8 3 1 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO26957.1 - 0.011 15.7 1.9 0.011 15.7 1.9 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETO26957.1 - 0.016 14.8 25.3 0.032 13.8 5.0 3.5 2 1 1 3 3 3 0 Zinc-ribbon, C4HC2 type zf-RING_5 PF14634.6 ETO26957.1 - 0.021 14.8 9.1 0.021 14.8 9.1 2.8 2 1 0 2 2 2 0 zinc-RING finger domain zf-HC5HC2H_2 PF13832.6 ETO26957.1 - 0.026 14.7 2.4 0.026 14.7 2.4 3.5 1 1 0 2 2 2 0 PHD-zinc-finger like domain YdjO PF14169.6 ETO26957.1 - 0.69 9.7 5.0 0.49 10.2 0.9 2.6 2 0 0 2 2 2 0 Cold-inducible protein YdjO PHD PF00628.29 ETO26957.1 - 1 9.3 30.2 1.2 9.1 6.4 4.1 2 1 1 3 3 3 0 PHD-finger zf-HC5HC2H PF13771.6 ETO26957.1 - 2.5 8.4 19.7 0.16 12.3 5.9 3.2 2 2 0 2 2 2 0 PHD-like zinc-binding domain Efg1 PF10153.9 ETO26958.1 - 0.97 9.8 13.5 1.1 9.7 6.1 2.8 2 0 0 2 2 2 0 rRNA-processing protein Efg1 Hom_end_hint PF05203.16 ETO26962.1 - 0.027 14.4 3.7 0.027 14.4 3.7 1.0 1 0 0 1 1 1 0 Hom_end-associated Hint Lipase_GDSL_3 PF14606.6 ETO26962.1 - 1.4 9.1 5.8 2.5 8.2 5.7 1.5 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family ANAPC1 PF12859.7 ETO26963.1 - 6.6e-08 33.2 0.4 0.00068 20.2 0.2 3.3 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 1 Pex24p PF06398.11 ETO26964.1 - 0.0052 15.8 1.6 0.0052 15.8 1.6 1.6 2 0 0 2 2 2 1 Integral peroxisomal membrane peroxin BORCS8 PF10167.9 ETO26964.1 - 0.0062 16.5 1.5 0.016 15.1 1.5 1.7 1 0 0 1 1 1 1 BLOC-1-related complex sub-unit 8 UPF0449 PF15136.6 ETO26964.1 - 0.03 14.8 0.5 0.03 14.8 0.5 1.9 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 ING PF12998.7 ETO26964.1 - 0.032 14.8 4.6 0.032 14.8 4.6 1.8 2 0 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding Borrelia_orfA PF02414.15 ETO26964.1 - 0.052 13.2 10.8 0.2 11.2 2.3 2.0 2 0 0 2 2 2 0 Borrelia ORF-A Reticulon PF02453.17 ETO26964.1 - 0.064 13.2 1.7 0.12 12.3 1.7 1.4 1 0 0 1 1 1 0 Reticulon DUF1664 PF07889.12 ETO26964.1 - 0.15 12.1 2.1 0.24 11.4 1.3 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) RIC3 PF15361.6 ETO26964.1 - 2.8 8.3 8.6 0.54 10.7 1.8 2.3 2 0 0 2 2 2 0 Resistance to inhibitors of cholinesterase homologue 3 ETRAMP PF09716.10 ETO26964.1 - 5 7.3 5.3 4.5 7.4 0.2 2.4 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Fez1 PF06818.15 ETO26965.1 - 1.2e-05 25.8 33.8 1.2e-05 25.8 33.8 1.5 2 0 0 2 2 2 1 Fez1 DUF3450 PF11932.8 ETO26965.1 - 0.00015 21.1 19.4 0.00015 21.1 19.4 2.9 1 1 2 3 3 3 1 Protein of unknown function (DUF3450) TPR_MLP1_2 PF07926.12 ETO26965.1 - 0.00016 21.8 13.4 0.00016 21.8 13.4 3.2 2 1 1 3 3 3 1 TPR/MLP1/MLP2-like protein SMBP PF16785.5 ETO26965.1 - 3.9 7.7 10.3 5.3 7.3 5.5 2.7 2 0 0 2 2 2 0 Small metal-binding protein DUF948 PF06103.11 ETO26965.1 - 5.8 7.2 6.0 24 5.3 4.0 2.7 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Spc7 PF08317.11 ETO26965.1 - 8 5.2 36.8 1.3e+02 1.3 36.8 2.1 1 1 0 1 1 1 0 Spc7 kinetochore protein Aminotran_5 PF00266.19 ETO26966.1 - 2.7e-06 26.6 0.0 3.3e-06 26.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V DUF5319 PF17252.2 ETO26966.1 - 0.038 14.2 0.0 0.052 13.8 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5319) vATP-synt_AC39 PF01992.16 ETO26967.1 - 1e-12 48.2 0.1 1.6e-12 47.6 0.1 1.3 1 1 0 1 1 1 1 ATP synthase (C/AC39) subunit G-alpha PF00503.20 ETO26968.1 - 1.4e-36 126.4 13.2 1.1e-34 120.2 13.2 3.0 1 1 0 1 1 1 1 G-protein alpha subunit AAA_29 PF13555.6 ETO26968.1 - 0.0016 18.1 0.1 0.0081 15.9 0.1 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO26968.1 - 0.008 16.6 0.0 0.012 16.0 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 ETO26968.1 - 0.015 14.5 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 ETO26968.1 - 0.016 14.5 0.0 0.037 13.4 0.0 1.5 1 0 0 1 1 1 0 FtsK/SpoIIIE family ABC_tran PF00005.27 ETO26968.1 - 0.017 15.6 0.4 0.017 15.6 0.4 2.3 2 2 0 2 2 2 0 ABC transporter RsgA_GTPase PF03193.16 ETO26968.1 - 0.018 14.9 0.5 0.12 12.2 0.0 2.4 3 0 0 3 3 3 0 RsgA GTPase AAA_5 PF07728.14 ETO26968.1 - 0.025 14.6 0.4 0.25 11.3 0.2 2.2 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) DAP3 PF10236.9 ETO26968.1 - 0.031 13.5 0.1 0.072 12.3 0.1 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 AAA_25 PF13481.6 ETO26968.1 - 0.052 13.1 0.0 0.14 11.7 0.0 1.6 2 0 0 2 2 2 0 AAA domain Arf PF00025.21 ETO26968.1 - 0.052 13.0 0.8 1.5 8.3 0.1 2.7 2 1 0 2 2 2 0 ADP-ribosylation factor family NACHT PF05729.12 ETO26968.1 - 0.053 13.4 0.1 0.21 11.5 0.0 2.0 2 0 0 2 2 2 0 NACHT domain DUF815 PF05673.13 ETO26968.1 - 0.069 12.3 0.0 0.12 11.5 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 ETO26968.1 - 0.12 12.5 0.4 11 6.2 0.1 2.5 2 0 0 2 2 2 0 50S ribosome-binding GTPase T2SSE PF00437.20 ETO26968.1 - 0.12 11.4 0.0 0.29 10.1 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein AAA_24 PF13479.6 ETO26968.1 - 0.12 12.0 1.8 0.28 10.9 0.3 2.5 2 2 0 3 3 3 0 AAA domain TrwB_AAD_bind PF10412.9 ETO26968.1 - 0.16 10.9 0.2 0.31 9.9 0.2 1.4 1 0 0 1 1 1 0 Type IV secretion-system coupling protein DNA-binding domain AAA_14 PF13173.6 ETO26968.1 - 0.38 10.8 4.6 0.34 10.9 0.8 2.8 3 1 0 3 3 3 0 AAA domain PA26 PF04636.13 ETO26971.1 - 6.2 5.6 10.4 6.5 5.6 10.4 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 ETO26972.1 - 2.8 6.6 5.4 3.4 6.4 5.4 1.1 1 0 0 1 1 1 0 Presenilin DUF4637 PF15470.6 ETO26972.1 - 3.6 7.3 8.4 0.94 9.2 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) DUF1664 PF07889.12 ETO26973.1 - 0.0066 16.5 8.9 0.0066 16.5 8.9 2.6 1 1 1 2 2 2 1 Protein of unknown function (DUF1664) CEP63 PF17045.5 ETO26973.1 - 0.038 13.9 49.4 0.046 13.6 49.4 1.1 1 0 0 1 1 1 0 Centrosomal protein of 63 kDa Syntaxin-6_N PF09177.11 ETO26973.1 - 0.064 13.8 29.7 0.13 12.8 6.5 3.4 1 1 1 2 2 2 0 Syntaxin 6, N-terminal DUF3584 PF12128.8 ETO26973.1 - 0.064 10.8 42.3 0.094 10.2 42.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) DUF724 PF05266.14 ETO26973.1 - 0.13 12.1 41.6 0.029 14.2 18.2 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF724) IFT57 PF10498.9 ETO26973.1 - 1.3 7.9 38.1 0.13 11.2 15.3 2.3 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 ATG16 PF08614.11 ETO26973.1 - 2.8 8.1 50.6 5.5 7.2 14.1 3.0 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) APG6_N PF17675.1 ETO26973.1 - 3.6 8.1 57.6 5.4 7.6 13.6 3.2 1 1 0 2 2 2 0 Apg6 coiled-coil region FlxA PF14282.6 ETO26973.1 - 4 7.5 55.6 0.52 10.3 20.2 3.3 2 1 1 3 3 3 0 FlxA-like protein TMF_TATA_bd PF12325.8 ETO26973.1 - 6.2 7.1 44.1 5.5 7.3 9.9 3.5 2 2 1 3 3 3 0 TATA element modulatory factor 1 TATA binding CALCOCO1 PF07888.11 ETO26973.1 - 6.3 5.5 47.4 11 4.8 47.4 1.3 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like YejG PF13989.6 ETO26973.1 - 7.2 7.1 8.3 1.2 9.6 0.8 2.7 1 1 1 3 3 3 0 YejG-like protein DUF4407 PF14362.6 ETO26973.1 - 9.5 5.5 39.8 2.2 7.6 25.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Flagellin_C PF00700.21 ETO26973.1 - 9.5 6.7 19.4 3.8 8.0 3.0 3.4 1 1 1 3 3 3 0 Bacterial flagellin C-terminal helical region WD40 PF00400.32 ETO26974.1 - 1e-38 130.6 22.3 4.6e-08 33.6 1.7 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26974.1 - 1.2e-12 48.0 1.0 0.0049 17.1 0.0 5.7 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO26974.1 - 9.4e-12 44.3 8.4 0.04 12.6 0.1 5.1 1 1 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO26974.1 - 6e-09 35.6 6.4 3.1e-05 23.5 0.6 4.7 2 2 3 5 5 5 2 WD40-like domain DUF4263 PF14082.6 ETO26974.1 - 0.057 13.7 0.0 4.6 7.5 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4263) ParA PF10609.9 ETO26975.1 - 3.9e-70 236.1 0.0 5.2e-70 235.7 0.0 1.1 1 0 0 1 1 1 1 NUBPL iron-transfer P-loop NTPase AAA_31 PF13614.6 ETO26975.1 - 2.5e-08 34.0 0.0 1.1e-07 31.9 0.0 1.9 1 1 0 1 1 1 1 AAA domain CbiA PF01656.23 ETO26975.1 - 3.7e-08 33.5 0.0 4.8e-08 33.1 0.0 1.2 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain MipZ PF09140.11 ETO26975.1 - 2.8e-07 30.1 0.0 5.6e-07 29.1 0.0 1.5 1 1 0 1 1 1 1 ATPase MipZ ArsA_ATPase PF02374.15 ETO26975.1 - 7.8e-06 25.3 0.0 3.8e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Anion-transporting ATPase MeaB PF03308.16 ETO26975.1 - 0.0022 17.1 0.0 0.003 16.6 0.0 1.2 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ETO26975.1 - 0.0051 16.7 0.0 0.0091 15.9 0.0 1.3 1 0 0 1 1 1 1 RsgA GTPase NB-ARC PF00931.22 ETO26975.1 - 0.0056 15.9 0.1 0.0086 15.3 0.1 1.3 1 0 0 1 1 1 1 NB-ARC domain CBP_BcsQ PF06564.12 ETO26975.1 - 0.0079 15.7 0.1 0.038 13.5 0.1 1.9 1 1 1 2 2 2 1 Cellulose biosynthesis protein BcsQ AAA_25 PF13481.6 ETO26975.1 - 0.0086 15.7 0.5 0.011 15.3 0.5 1.4 1 1 0 1 1 1 1 AAA domain APS_kinase PF01583.20 ETO26975.1 - 0.07 13.0 0.0 0.11 12.4 0.0 1.3 1 0 0 1 1 1 0 Adenylylsulphate kinase TsaE PF02367.17 ETO26975.1 - 0.077 13.0 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Rad17 PF03215.15 ETO26975.1 - 0.1 12.5 0.0 0.34 10.8 0.0 1.7 2 0 0 2 2 2 0 Rad17 P-loop domain NTPase_1 PF03266.15 ETO26975.1 - 0.13 12.1 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 NTPase AAA_18 PF13238.6 ETO26975.1 - 0.13 12.8 0.1 0.19 12.3 0.1 1.6 1 1 0 1 1 1 0 AAA domain Fer4_NifH PF00142.18 ETO26975.1 - 0.19 11.1 0.0 0.3 10.5 0.0 1.3 1 0 0 1 1 1 0 4Fe-4S iron sulfur cluster binding proteins, NifH/frxC family FAP206 PF12018.8 ETO26976.1 - 1.9e-17 63.7 5.3 1.9e-17 63.7 5.3 1.8 2 0 0 2 2 2 1 Domain of unknown function Mur_ligase_M PF08245.12 ETO26977.1 - 2.5e-09 37.4 0.0 2.2e-08 34.3 0.0 1.9 1 1 0 1 1 1 1 Mur ligase middle domain MutS_I PF01624.20 ETO26977.1 - 0.042 14.1 0.1 0.073 13.3 0.1 1.3 1 0 0 1 1 1 0 MutS domain I HTH_45 PF14947.6 ETO26977.1 - 0.11 12.5 0.5 0.38 10.8 0.1 2.0 2 0 0 2 2 2 0 Winged helix-turn-helix EF-hand_7 PF13499.6 ETO26978.1 - 7.6e-09 35.9 9.8 4.3e-05 23.9 5.1 2.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO26978.1 - 3.5e-08 32.7 1.2 1.6e-06 27.6 0.2 2.6 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ETO26978.1 - 4.1e-08 32.2 0.7 2.3e-06 26.7 0.2 2.6 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 ETO26978.1 - 1.2e-06 27.7 0.3 3.5e-06 26.3 0.3 1.8 1 0 0 1 1 1 1 EF hand Na_Ca_ex PF01699.24 ETO26978.1 - 5.1e-06 26.5 4.4 5.1e-06 26.5 4.4 1.8 2 0 0 2 2 2 1 Sodium/calcium exchanger protein EF-hand_8 PF13833.6 ETO26978.1 - 0.0003 20.6 0.2 0.0024 17.7 0.0 2.4 2 0 0 2 2 2 1 EF-hand domain pair Caleosin PF05042.13 ETO26978.1 - 0.022 14.7 0.1 0.066 13.1 0.1 1.8 1 1 1 2 2 2 0 Caleosin related protein SurA_N_3 PF13624.6 ETO26978.1 - 0.29 10.9 2.4 0.15 11.8 0.2 1.8 2 0 0 2 2 2 0 SurA N-terminal domain Rpp20 PF12328.8 ETO26978.1 - 0.54 10.2 3.5 1.5 8.8 3.5 1.8 1 1 0 1 1 1 0 Rpp20 subunit of nuclear RNase MRP and P ATG13 PF10033.9 ETO26980.1 - 1.3e-06 28.3 1.6 0.0055 16.4 0.0 3.0 3 1 0 3 3 3 2 Autophagy-related protein 13 Caldesmon PF02029.15 ETO26980.1 - 0.16 10.7 28.6 0.53 9.0 14.7 2.1 2 0 0 2 2 2 0 Caldesmon DUF1425 PF07233.12 ETO26980.1 - 0.35 10.8 3.1 0.4 10.6 1.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1425) CDC27 PF09507.10 ETO26980.1 - 0.35 10.2 32.8 0.056 12.8 12.4 2.2 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 UBX PF00789.20 ETO26981.1 - 3.6e-12 46.3 0.0 8.3e-12 45.1 0.0 1.7 1 0 0 1 1 1 1 UBX domain Tmemb_9 PF05434.11 ETO26981.1 - 0.0083 16.0 6.4 0.64 9.9 0.0 3.2 3 0 0 3 3 3 2 TMEM9 Ctr PF04145.15 ETO26981.1 - 0.031 14.9 2.2 11 6.7 0.3 3.2 3 0 0 3 3 3 0 Ctr copper transporter family DUF4834 PF16118.5 ETO26981.1 - 0.11 13.5 0.1 0.11 13.5 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Folate_carrier PF01770.18 ETO26981.1 - 2.7 6.7 5.8 6.8 5.3 0.0 2.8 3 0 0 3 3 3 0 Reduced folate carrier Secretin_N_2 PF07655.13 ETO26981.1 - 4.5 7.9 25.2 6.4 7.4 6.9 2.7 2 0 0 2 2 2 0 Secretin N-terminal domain NMO PF03060.15 ETO26982.1 - 1.1e-15 57.8 0.0 1.4e-15 57.6 0.0 1.0 1 0 0 1 1 1 1 Nitronate monooxygenase NMO PF03060.15 ETO26983.1 - 3.7e-16 59.4 0.3 6.3e-16 58.7 0.3 1.3 1 1 0 1 1 1 1 Nitronate monooxygenase IMPDH PF00478.25 ETO26983.1 - 2.3e-06 26.9 0.1 3e-06 26.5 0.1 1.1 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain Cpn60_TCP1 PF00118.24 ETO26983.1 - 0.0084 14.8 0.0 0.011 14.4 0.0 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Period_C PF12114.8 ETO26984.1 - 3 7.4 6.3 5.3 6.6 6.3 1.5 1 0 0 1 1 1 0 Period protein 2/3C-terminal region AlaDh_PNT_N PF05222.15 ETO26985.1 - 2.4e-25 89.4 0.0 3.6e-25 88.8 0.0 1.3 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain Saccharop_dh_N PF04455.12 ETO26986.1 - 2.6e-10 40.6 0.1 3.5e-10 40.2 0.1 1.3 1 0 0 1 1 1 1 LOR/SDH bifunctional enzyme conserved region Sacchrp_dh_C PF16653.5 ETO26987.1 - 4.9e-43 148.1 0.0 7.5e-42 144.3 0.0 2.2 1 1 0 1 1 1 1 Saccharopine dehydrogenase C-terminal domain Sacchrp_dh_NADP PF03435.18 ETO26987.1 - 2.1e-13 50.6 0.1 3.6e-13 49.9 0.1 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain NAD_binding_10 PF13460.6 ETO26987.1 - 0.057 13.3 0.0 0.097 12.6 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding PI3Ka PF00613.20 ETO26988.1 - 1.6e-05 24.4 0.4 2.8e-05 23.6 0.4 1.3 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Rif1_N PF12231.8 ETO26988.1 - 0.037 13.0 1.0 0.13 11.2 0.1 2.0 2 0 0 2 2 2 0 Rap1-interacting factor 1 N terminal HALZ PF02183.18 ETO26990.1 - 0.008 16.4 1.8 0.02 15.1 1.8 1.8 1 0 0 1 1 1 1 Homeobox associated leucine zipper Tup_N PF08581.10 ETO26990.1 - 0.035 14.4 5.4 0.048 14.0 5.4 1.4 1 0 0 1 1 1 0 Tup N-terminal Hira PF07569.11 ETO26991.1 - 0.00074 19.3 1.0 0.45 10.2 0.1 2.9 2 1 1 3 3 3 2 TUP1-like enhancer of split WD40 PF00400.32 ETO26991.1 - 0.0012 19.6 0.2 0.0012 19.6 0.2 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat Amnionless PF14828.6 ETO26992.1 - 0.0036 16.2 0.5 0.0061 15.4 0.5 1.3 1 0 0 1 1 1 1 Amnionless Shisa PF13908.6 ETO26992.1 - 0.22 11.7 1.5 0.51 10.6 0.1 2.3 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator IgaA PF07095.11 ETO26992.1 - 0.36 8.8 2.4 0.55 8.2 2.4 1.1 1 0 0 1 1 1 0 Intracellular growth attenuator protein IgaA V_ATPase_I PF01496.19 ETO26992.1 - 1.2 6.9 10.7 2.1 6.2 7.6 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Peptidase_S49_N PF08496.10 ETO26992.1 - 1.5 8.8 7.3 4.2 7.4 7.3 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal SprA-related PF12118.8 ETO26992.1 - 2.8 7.0 15.7 6 5.9 15.7 1.5 1 0 0 1 1 1 0 SprA-related family Exonuc_VII_L PF02601.15 ETO26992.1 - 3.5 7.1 11.6 8 5.9 11.6 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Zip PF02535.22 ETO26992.1 - 4 6.6 5.0 8.3 5.5 5.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO26992.1 - 4.4 6.0 13.0 12 4.5 8.8 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Atrophin-1 PF03154.15 ETO26992.1 - 4.5 5.4 24.2 7.3 4.7 24.2 1.3 1 0 0 1 1 1 0 Atrophin-1 family Nucleoside_tran PF01733.18 ETO26992.1 - 8.3 5.7 5.8 1 8.7 0.4 2.0 1 1 1 2 2 2 0 Nucleoside transporter WD40 PF00400.32 ETO26994.1 - 1.2e-55 184.1 13.0 5.7e-10 39.6 0.0 7.2 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO26994.1 - 7.5e-22 77.4 2.5 0.00062 20.0 0.0 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO26994.1 - 7.7e-17 61.2 0.4 0.00012 21.2 0.1 5.2 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO26994.1 - 4.2e-13 49.6 1.0 3e-05 24.0 0.0 3.7 2 1 3 5 5 5 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO26994.1 - 1.7e-11 43.5 4.2 0.059 12.0 0.0 4.8 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO26994.1 - 5.8e-09 35.7 0.4 0.012 15.0 0.0 3.3 3 0 0 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO26994.1 - 1.5e-05 23.7 2.5 0.027 13.0 0.0 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO26994.1 - 6.8e-05 21.9 4.7 0.34 9.8 0.0 4.2 1 1 4 5 5 5 2 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO26994.1 - 0.00015 21.6 0.7 7.3 6.7 0.0 5.1 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF1513 PF07433.11 ETO26994.1 - 0.00022 20.4 0.1 0.13 11.3 0.1 3.3 1 1 0 3 3 3 1 Protein of unknown function (DUF1513) DPPIV_N PF00930.21 ETO26994.1 - 0.0004 19.2 0.1 0.54 9.0 0.0 3.2 2 2 1 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region AcetylCoA_hyd_C PF13336.6 ETO26994.1 - 0.044 13.7 0.1 0.18 11.8 0.0 2.0 2 0 0 2 2 2 0 Acetyl-CoA hydrolase/transferase C-terminal domain HPS6 PF15702.5 ETO26994.1 - 0.12 10.4 0.1 14 3.5 0.0 3.2 1 1 2 4 4 4 0 Hermansky-Pudlak syndrome 6 protein Big_7 PF17957.1 ETO26994.1 - 0.45 11.3 2.1 5 8.0 0.0 3.4 3 1 1 4 4 4 0 Bacterial Ig domain Rhomboid PF01694.22 ETO26995.1 - 2.1e-06 27.8 0.1 2.1e-05 24.6 0.1 2.0 1 1 0 1 1 1 1 Rhomboid family DUF4491 PF14898.6 ETO26995.1 - 0.27 11.7 2.1 12 6.5 0.1 2.8 3 1 1 4 4 4 0 Domain of unknown function (DUF4491) SSP160 PF06933.11 ETO26997.1 - 3.2 5.9 19.8 0.029 12.6 8.5 2.1 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO26997.1 - 6.1 6.8 24.0 15 5.6 24.0 1.6 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3573 PF12097.8 ETO26997.1 - 7.6 5.2 16.6 0.094 11.5 6.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) Hamartin PF04388.12 ETO26997.1 - 7.8 5.0 32.3 16 4.0 32.3 1.5 1 0 0 1 1 1 0 Hamartin protein CH PF00307.31 ETO26998.1 - 9.9e-16 57.9 0.0 1.2e-15 57.6 0.0 1.1 1 0 0 1 1 1 1 Calponin homology (CH) domain HAP1_N PF04849.13 ETO26999.1 - 0.0043 16.3 9.4 0.0043 16.3 9.4 1.3 2 0 0 2 2 2 1 HAP1 N-terminal conserved region Swi5 PF07061.11 ETO26999.1 - 0.01 15.9 8.2 0.023 14.8 8.2 1.6 1 0 0 1 1 1 0 Swi5 FBPase_2 PF06874.11 ETO26999.1 - 0.035 12.4 9.9 0.39 9.0 9.9 1.9 1 1 0 1 1 1 0 Firmicute fructose-1,6-bisphosphatase Tropomyosin_1 PF12718.7 ETO26999.1 - 0.063 13.4 13.1 0.1 12.8 13.1 1.3 1 0 0 1 1 1 0 Tropomyosin like zf-CCCH_7 PF18586.1 ETO26999.1 - 0.14 12.5 1.8 0.34 11.3 1.0 2.1 2 0 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Atg14 PF10186.9 ETO26999.1 - 0.14 11.2 8.9 0.2 10.7 8.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF641 PF04859.12 ETO26999.1 - 0.2 12.0 5.7 0.2 12.0 4.8 1.5 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) HMMR_N PF15905.5 ETO26999.1 - 0.29 10.6 16.4 0.36 10.3 16.4 1.1 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal FAM76 PF16046.5 ETO26999.1 - 0.31 10.4 11.9 0.4 10.0 11.9 1.1 1 0 0 1 1 1 0 FAM76 protein Ribosomal_L27A PF00828.19 ETO26999.1 - 1.7 9.3 5.1 2.5 8.8 5.1 1.4 1 0 0 1 1 1 0 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A DivIC PF04977.15 ETO26999.1 - 2.6 7.9 13.8 8 6.3 10.1 3.0 1 1 1 2 2 2 0 Septum formation initiator Med4 PF10018.9 ETO26999.1 - 3.1 7.4 10.9 4.2 7.0 10.9 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF16 PF01519.16 ETO26999.1 - 8.4 6.9 14.9 16 6.0 14.7 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 Cyto_heme_lyase PF01265.17 ETO27000.1 - 0.014 15.0 3.4 0.018 14.7 2.8 1.4 1 1 0 1 1 1 0 Cytochrome c/c1 heme lyase zf-C6H2 PF15801.5 ETO27000.1 - 0.084 13.2 0.1 0.084 13.2 0.1 2.9 2 1 1 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding PTS_2-RNA PF01885.16 ETO27001.1 - 2.9e-47 161.1 0.3 8.4e-47 159.5 0.3 1.7 1 1 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family Presenilin PF01080.17 ETO27001.1 - 0.12 11.1 13.9 0.14 10.9 13.9 1.1 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 ETO27001.1 - 0.17 12.1 4.5 0.25 11.5 4.5 1.4 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 ETO27001.1 - 0.52 8.5 20.5 0.7 8.1 20.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 ETO27001.1 - 2.2 8.3 7.9 3 7.8 7.9 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Nop14 PF04147.12 ETO27001.1 - 2.3 6.3 24.1 3 5.9 24.1 1.1 1 0 0 1 1 1 0 Nop14-like family ALMT PF11744.8 ETO27001.1 - 3.9 6.2 8.5 5 5.9 8.5 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter SLC12 PF03522.15 ETO27001.1 - 4.6 6.2 15.9 6.1 5.8 15.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 adh_short PF00106.25 ETO27002.1 - 2.1e-11 43.6 0.1 2.8e-11 43.3 0.1 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO27002.1 - 8.4e-07 28.8 0.0 1.1e-06 28.4 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase THF_DHG_CYH_C PF02882.19 ETO27002.1 - 4.7e-05 22.8 0.0 0.051 12.9 0.0 2.1 1 1 1 2 2 2 2 Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain KR PF08659.10 ETO27002.1 - 5.5e-05 23.2 0.0 6.7e-05 22.9 0.0 1.3 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO27002.1 - 0.0013 17.9 0.0 0.0016 17.6 0.0 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein Sacchrp_dh_NADP PF03435.18 ETO27002.1 - 0.0016 18.7 0.0 0.0022 18.3 0.0 1.3 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Shikimate_DH PF01488.20 ETO27002.1 - 0.0046 17.0 0.1 0.0093 16.0 0.1 1.5 1 1 0 1 1 1 1 Shikimate / quinate 5-dehydrogenase ApbA PF02558.16 ETO27002.1 - 0.015 15.0 0.0 0.019 14.6 0.0 1.2 1 0 0 1 1 1 0 Ketopantoate reductase PanE/ApbA Denso_VP4 PF02336.15 ETO27002.1 - 0.037 13.0 0.0 0.049 12.5 0.0 1.1 1 0 0 1 1 1 0 Capsid protein VP4 His_biosynth PF00977.21 ETO27002.1 - 0.064 12.7 0.1 0.077 12.4 0.1 1.2 1 0 0 1 1 1 0 Histidine biosynthesis protein Epimerase PF01370.21 ETO27002.1 - 0.078 12.4 0.0 0.15 11.5 0.0 1.5 1 1 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF4174 PF13778.6 ETO27002.1 - 0.12 12.9 0.2 0.19 12.2 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4174) DivIC PF04977.15 ETO27003.1 - 0.0087 15.8 3.1 0.0087 15.8 3.1 10.3 4 2 5 9 9 9 2 Septum formation initiator ATG16 PF08614.11 ETO27003.1 - 0.017 15.3 14.1 0.017 15.3 14.1 6.8 3 2 2 5 5 5 0 Autophagy protein 16 (ATG16) bZIP_1 PF00170.21 ETO27003.1 - 0.025 14.7 1.3 0.025 14.7 1.3 11.2 5 4 7 12 12 12 0 bZIP transcription factor YabA PF06156.13 ETO27003.1 - 0.026 15.1 2.1 0.026 15.1 2.1 7.6 3 2 3 7 7 7 0 Initiation control protein YabA HJURP_C PF12347.8 ETO27003.1 - 0.068 13.2 1.6 0.23 11.5 1.6 2.0 1 0 0 1 1 1 0 Holliday junction regulator protein family C-terminal repeat ArsP_1 PF03773.13 ETO27003.1 - 5.3 6.1 5.1 1.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Predicted permease Ribosomal_L22e PF01776.17 ETO27004.1 - 7.5e-14 52.0 0.2 7.5e-14 52.0 0.2 1.6 2 0 0 2 2 2 1 Ribosomal L22e protein family ORC6 PF05460.13 ETO27004.1 - 0.22 10.7 8.6 0.25 10.6 8.6 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DOR PF14839.6 ETO27004.1 - 0.31 11.0 6.5 0.38 10.7 6.5 1.1 1 0 0 1 1 1 0 DOR family TPR_12 PF13424.6 ETO27005.1 - 1e-25 89.8 0.0 8e-10 38.9 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27005.1 - 3.7e-12 45.4 11.5 0.00098 19.2 0.2 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27005.1 - 1.3e-11 43.6 0.0 0.025 14.6 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27005.1 - 2.8e-11 42.7 14.5 0.0025 17.5 0.2 5.5 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27005.1 - 2.5e-10 39.9 0.0 0.14 12.1 0.0 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27005.1 - 2.9e-07 30.1 5.9 0.46 10.7 0.2 4.9 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27005.1 - 0.00069 19.3 3.2 9.6 6.0 0.1 5.2 4 1 1 5 5 5 1 TPR repeat MIT PF04212.18 ETO27005.1 - 0.0053 16.8 0.4 0.76 9.9 0.0 3.0 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO27005.1 - 0.014 16.0 0.2 17 6.3 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Pkinase PF00069.25 ETO27007.1 - 7.6e-63 212.3 0.0 1.2e-62 211.7 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27007.1 - 1.3e-30 106.6 0.0 1.9e-30 106.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO27007.1 - 2.4e-05 23.8 0.0 4e-05 23.1 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO27007.1 - 0.0003 20.2 0.0 0.00057 19.3 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DcrB PF08786.11 ETO27007.1 - 0.011 15.8 0.2 0.027 14.6 0.2 1.6 1 0 0 1 1 1 0 DcrB APH PF01636.23 ETO27007.1 - 0.013 15.4 0.1 0.04 13.8 0.0 1.8 2 1 0 2 2 2 0 Phosphotransferase enzyme family PKK PF12474.8 ETO27007.1 - 0.045 13.9 3.0 0.1 12.7 3.0 1.5 1 0 0 1 1 1 0 Polo kinase kinase Ribosomal_S4 PF00163.19 ETO27007.1 - 0.078 13.9 2.8 0.23 12.4 2.8 1.8 1 0 0 1 1 1 0 Ribosomal protein S4/S9 N-terminal domain Ubiq_cyt_C_chap PF03981.12 ETO27007.1 - 0.14 12.2 0.1 0.28 11.3 0.1 1.4 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone RNase_Zc3h12a PF11977.8 ETO27008.1 - 2.4e-16 59.9 0.0 3.2e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Zc3h12a-like Ribonuclease NYN domain PRORP PF16953.5 ETO27008.1 - 1.5e-05 24.6 0.0 0.0001 21.9 0.0 1.9 1 1 0 1 1 1 1 Protein-only RNase P zf-RanBP PF00641.18 ETO27008.1 - 0.036 13.4 1.9 0.059 12.7 1.9 1.3 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others DZR PF12773.7 ETO27008.1 - 0.038 14.0 2.1 0.074 13.1 1.5 1.7 2 0 0 2 2 2 0 Double zinc ribbon CbiX PF01903.17 ETO27008.1 - 0.12 12.7 0.0 0.24 11.8 0.0 1.4 1 0 0 1 1 1 0 CbiX EST1_DNA_bind PF10373.9 ETO27009.1 - 0.0029 17.1 2.2 0.0029 17.1 2.2 2.6 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain zf-C2H2 PF00096.26 ETO27010.1 - 8.6e-06 25.9 21.9 0.00028 21.2 3.6 3.2 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO27010.1 - 0.0047 17.7 11.6 0.085 13.7 2.8 2.8 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO27010.1 - 0.12 12.8 0.3 0.12 12.8 0.3 3.9 4 0 0 4 4 4 0 Zinc-finger double domain KIAA1328 PF15369.6 ETO27010.1 - 0.14 12.0 10.2 0.21 11.4 10.2 1.4 1 0 0 1 1 1 0 Uncharacterised protein KIAA1328 IBR PF01485.21 ETO27010.1 - 0.16 12.2 5.2 0.35 11.1 5.2 1.6 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain DUF4746 PF15928.5 ETO27010.1 - 0.37 10.2 7.3 0.52 9.7 7.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Toxin_10 PF05431.11 ETO27010.1 - 3.4 7.1 10.4 7.3 6.0 9.3 1.8 1 1 1 2 2 2 0 Insecticidal Crystal Toxin, P42 PPP4R2 PF09184.11 ETO27010.1 - 6.7 6.2 18.0 11 5.5 18.0 1.3 1 0 0 1 1 1 0 PPP4R2 NYD-SP28 PF14772.6 ETO27012.1 - 8.1e-16 57.9 13.6 8.1e-16 57.9 13.6 5.7 2 2 2 6 6 6 1 Sperm tail KIF1B PF12423.8 ETO27012.1 - 9.4 6.8 8.8 10 6.7 0.7 3.9 3 0 0 3 3 3 0 Kinesin protein 1B NYD-SP28_assoc PF14775.6 ETO27013.1 - 2e-16 59.8 8.3 4.7e-16 58.6 8.3 1.7 1 0 0 1 1 1 1 Sperm tail C-terminal domain Flagellar_rod PF05149.12 ETO27013.1 - 0.31 10.5 8.6 0.59 9.5 8.6 1.4 1 0 0 1 1 1 0 Paraflagellar rod protein AAA_23 PF13476.6 ETO27013.1 - 1.6 9.2 12.4 1.9 9.0 11.6 1.6 1 1 0 1 1 1 0 AAA domain CEL_III_C PF18054.1 ETO27013.1 - 4.7 7.3 9.0 1 9.4 2.0 2.5 3 0 0 3 3 3 0 CEL-III C-terminal TPR_12 PF13424.6 ETO27015.1 - 8.6e-62 205.4 22.0 1.5e-17 63.6 2.7 5.2 2 1 2 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27015.1 - 3.2e-40 134.9 3.9 2.8e-06 27.0 0.0 7.5 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27015.1 - 1.4e-35 118.7 12.9 5e-05 23.0 0.0 7.6 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27015.1 - 1.6e-35 119.5 45.8 8.8e-08 31.7 0.5 7.2 8 0 0 8 8 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27015.1 - 1.9e-34 114.9 38.1 1.5e-06 28.0 0.6 7.7 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27015.1 - 3.3e-26 89.3 28.5 9.3e-05 22.3 0.4 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27015.1 - 2.2e-11 43.3 15.3 0.2 12.1 0.0 7.7 7 1 0 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27015.1 - 1.6e-09 37.3 42.1 0.0056 16.3 2.6 9.2 6 2 2 8 8 8 5 TPR repeat TPR_14 PF13428.6 ETO27015.1 - 2.5e-09 37.2 0.2 1.7 9.7 0.0 6.8 7 0 0 7 7 6 1 Tetratricopeptide repeat SNAP PF14938.6 ETO27015.1 - 3.7e-08 33.1 14.7 0.0008 18.9 5.3 2.9 1 1 2 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO27015.1 - 1.4e-07 31.7 15.7 0.59 10.9 0.5 7.3 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO27015.1 - 5.1e-07 30.2 0.3 6.9 7.4 0.4 5.8 5 2 0 5 5 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO27015.1 - 8.6e-05 22.1 0.7 0.00065 19.2 0.8 2.1 1 1 2 3 3 3 2 MalT-like TPR region DUF627 PF04781.12 ETO27015.1 - 0.0035 17.3 3.5 0.047 13.7 2.2 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF627) Sel1 PF08238.12 ETO27015.1 - 0.011 16.5 7.7 12 6.8 0.1 5.3 5 1 0 5 5 5 0 Sel1 repeat ANAPC3 PF12895.7 ETO27015.1 - 0.015 15.5 19.5 0.19 12.0 1.9 4.0 2 1 2 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4404 PF14357.6 ETO27015.1 - 0.018 15.7 0.1 0.047 14.3 0.1 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4404) RPN7 PF10602.9 ETO27015.1 - 0.032 14.0 15.4 3.5 7.3 0.3 5.2 4 2 2 6 6 6 0 26S proteasome subunit RPN7 Phage_term_sma PF07141.11 ETO27015.1 - 0.1 12.4 0.6 0.4 10.4 0.1 2.2 2 0 0 2 2 2 0 Putative bacteriophage terminase small subunit SPO22 PF08631.10 ETO27015.1 - 0.12 11.9 5.4 1.5 8.2 0.7 3.0 2 2 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 ETO27015.1 - 0.23 12.0 13.0 0.59 10.7 1.1 4.7 2 1 5 7 7 7 0 Tetratricopeptide repeat MIT PF04212.18 ETO27015.1 - 4.4 7.4 21.1 9.5 6.4 0.0 5.7 6 0 0 6 6 5 0 MIT (microtubule interacting and transport) domain MMR_HSR1 PF01926.23 ETO27016.1 - 1.5e-05 25.0 0.0 4.3e-05 23.6 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase G-alpha PF00503.20 ETO27016.1 - 0.00058 19.1 5.7 0.0033 16.7 5.7 2.3 1 1 0 1 1 1 1 G-protein alpha subunit AIG1 PF04548.16 ETO27016.1 - 0.0011 18.4 0.4 0.048 13.0 0.4 2.6 1 1 0 1 1 1 1 AIG1 family Septin PF00735.18 ETO27016.1 - 0.0011 18.3 0.1 0.0011 18.3 0.1 2.5 3 0 0 3 3 3 1 Septin Gtr1_RagA PF04670.12 ETO27016.1 - 0.0015 17.9 0.1 0.0033 16.8 0.1 1.7 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO27016.1 - 0.0046 16.5 0.0 0.01 15.4 0.0 1.6 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_29 PF13555.6 ETO27016.1 - 0.0072 16.1 0.1 0.015 15.0 0.1 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ETO27016.1 - 0.0077 15.6 0.0 0.029 13.7 0.0 2.0 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_5 PF07728.14 ETO27016.1 - 0.012 15.6 0.0 0.028 14.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ETO27016.1 - 0.015 15.2 0.6 0.11 12.4 0.6 2.3 1 1 0 1 1 1 0 RsgA GTPase PduV-EutP PF10662.9 ETO27016.1 - 0.018 14.8 0.5 0.094 12.5 0.1 2.3 1 1 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation ABC_tran PF00005.27 ETO27016.1 - 0.021 15.3 3.1 0.16 12.5 3.0 2.6 1 1 0 1 1 1 0 ABC transporter SRP54 PF00448.22 ETO27016.1 - 0.036 13.7 0.0 1.5 8.5 0.0 3.0 2 1 1 3 3 3 0 SRP54-type protein, GTPase domain TIP49 PF06068.13 ETO27016.1 - 0.054 12.7 0.1 0.97 8.6 0.0 2.3 2 0 0 2 2 2 0 TIP49 P-loop domain Roc PF08477.13 ETO27016.1 - 0.059 13.6 0.2 0.22 11.8 0.0 2.1 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Zeta_toxin PF06414.12 ETO27016.1 - 0.065 12.5 0.0 0.13 11.5 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin AAA_24 PF13479.6 ETO27016.1 - 0.071 12.8 0.3 0.31 10.7 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO27016.1 - 0.091 13.1 0.0 0.19 12.1 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 ETO27016.1 - 0.47 10.5 5.3 0.21 11.6 0.3 2.6 2 1 1 3 3 3 0 Dynamin family HSP70 PF00012.20 ETO27017.1 - 5.4e-29 100.9 2.0 5.4e-29 100.9 2.0 1.3 1 1 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO27017.1 - 3.7e-07 29.3 0.1 6.2e-07 28.5 0.1 1.3 1 1 0 1 1 1 1 MreB/Mbl protein PilM_2 PF11104.8 ETO27017.1 - 0.0095 15.0 0.1 0.02 13.9 0.0 1.6 2 0 0 2 2 2 1 Type IV pilus assembly protein PilM; Orf78 PF06024.12 ETO27018.1 - 0.016 15.5 2.0 0.94 9.8 0.3 3.0 3 0 0 3 3 3 0 Orf78 (ac78) BatA PF07584.11 ETO27018.1 - 0.043 14.2 1.5 0.043 14.2 1.5 3.5 3 1 0 3 3 3 0 Aerotolerance regulator N-terminal 7TM_GPCR_Srab PF10292.9 ETO27018.1 - 0.82 8.5 5.7 0.062 12.2 0.5 1.7 2 0 0 2 2 2 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor CPSF100_C PF13299.6 ETO27019.1 - 4.2 7.5 18.7 0.24 11.6 1.5 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal FAM60A PF15396.6 ETO27019.1 - 5.7 6.9 24.2 0.12 12.4 4.7 2.1 2 0 0 2 2 2 0 Protein Family FAM60A SID-1_RNA_chan PF13965.6 ETO27019.1 - 6.9 4.9 5.4 2.7 6.3 3.1 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Ldh_1_C PF02866.18 ETO27020.1 - 8.9e-28 97.3 0.4 6.9e-27 94.4 0.0 2.0 2 0 0 2 2 2 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain Ldh_1_N PF00056.23 ETO27020.1 - 1.4e-16 60.9 0.3 5.4e-16 59.0 0.3 1.9 1 1 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain UL20 PF17582.2 ETO27020.1 - 0.04 13.2 0.6 0.072 12.4 0.6 1.3 1 0 0 1 1 1 0 Cytomegalovirus UL20 HEAT PF02985.22 ETO27021.1 - 1.6e-07 30.9 0.0 0.0096 16.1 0.0 3.7 3 0 0 3 3 3 2 HEAT repeat Cnd1 PF12717.7 ETO27021.1 - 2.9e-05 24.1 0.1 0.0045 17.0 0.0 3.0 2 1 1 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO27021.1 - 3.8e-05 24.0 0.0 0.024 15.0 0.0 2.4 1 1 1 2 2 2 2 HEAT repeats Adaptin_N PF01602.20 ETO27021.1 - 0.00014 20.6 0.0 0.00019 20.2 0.0 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Ric8 PF10165.9 ETO27021.1 - 0.025 13.6 0.5 0.16 10.9 0.0 2.2 2 0 0 2 2 2 0 Guanine nucleotide exchange factor synembryn HEAT_EZ PF13513.6 ETO27021.1 - 0.041 14.4 0.0 0.13 12.8 0.0 1.9 1 0 0 1 1 1 0 HEAT-like repeat Adaptin_N PF01602.20 ETO27025.1 - 3.5e-97 326.1 11.4 4.4e-97 325.8 11.4 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO27025.1 - 7.4e-53 178.9 4.4 5.2e-52 176.1 0.1 2.8 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 ETO27025.1 - 6.8e-19 68.0 0.1 1.9e-18 66.6 0.1 1.8 1 0 0 1 1 1 1 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 ETO27025.1 - 1.7e-14 54.0 6.3 2.2e-05 24.7 0.0 4.7 3 1 0 4 4 4 4 HEAT repeats HEAT PF02985.22 ETO27025.1 - 4.8e-08 32.6 3.8 0.051 13.9 0.0 5.4 5 0 0 5 5 5 2 HEAT repeat Arm_2 PF04826.13 ETO27025.1 - 0.0017 17.8 2.4 0.0069 15.9 0.0 2.8 1 1 2 3 3 3 1 Armadillo-like Arm PF00514.23 ETO27025.1 - 0.0091 16.0 1.6 0.76 9.9 0.0 4.1 5 0 0 5 5 5 1 Armadillo/beta-catenin-like repeat GNAT_acetyltr_2 PF13718.6 ETO27025.1 - 0.057 12.8 2.0 0.14 11.6 2.0 1.6 1 0 0 1 1 1 0 GNAT acetyltransferase 2 GET2 PF08690.10 ETO27025.1 - 0.09 12.4 5.8 0.19 11.4 5.8 1.4 1 0 0 1 1 1 0 GET complex subunit GET2 DUF913 PF06025.12 ETO27025.1 - 0.27 10.1 3.3 0.54 9.2 3.3 1.4 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) POPLD PF08170.12 ETO27025.1 - 0.51 10.7 1.9 1.3 9.4 1.9 1.6 1 0 0 1 1 1 0 POPLD (NUC188) domain Nop14 PF04147.12 ETO27025.1 - 0.82 7.8 16.2 1.7 6.8 16.2 1.4 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 ETO27025.1 - 0.85 9.0 11.5 1.8 7.9 11.5 1.5 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 ETO27025.1 - 1.1 9.0 12.5 1.9 8.2 12.5 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO27025.1 - 1.1 8.4 4.9 1.7 7.8 4.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter RTP1_C1 PF10363.9 ETO27025.1 - 1.3 9.3 9.1 5.4 7.2 0.0 4.2 1 1 2 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Sec7_N PF12783.7 ETO27025.1 - 2.3 8.1 5.4 1.1 9.1 1.8 2.3 2 1 0 2 2 2 0 Guanine nucleotide exchange factor in Golgi transport N-terminal Presenilin PF01080.17 ETO27025.1 - 2.8 6.6 9.6 4.7 5.9 9.6 1.2 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 ETO27025.1 - 5.6 6.4 9.2 11 5.5 9.2 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 CDC45 PF02724.14 ETO27025.1 - 7.1 4.8 18.6 11 4.2 18.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_L26 PF16906.5 ETO27026.1 - 6.1e-07 29.8 1.5 2.2e-05 24.8 1.5 2.3 1 1 0 1 1 1 1 Ribosomal proteins L26 eukaryotic, L24P archaeal KOW PF00467.29 ETO27026.1 - 0.0061 16.5 2.4 0.21 11.6 0.2 2.5 2 0 0 2 2 2 2 KOW motif DUF4860 PF16152.5 ETO27027.1 - 0.077 12.9 0.6 2.2 8.2 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4860) ArfGap PF01412.18 ETO27028.1 - 7.3e-29 100.2 1.1 7.3e-29 100.2 1.1 1.8 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf C2 PF00168.30 ETO27028.1 - 6.6e-19 68.1 0.0 1.3e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 C2 domain B9-C2 PF07162.11 ETO27028.1 - 0.1 12.8 0.0 0.18 12.0 0.0 1.3 1 0 0 1 1 1 0 Ciliary basal body-associated, B9 protein YolD PF08863.10 ETO27028.1 - 0.11 12.5 0.0 0.39 10.8 0.0 1.8 1 0 0 1 1 1 0 YolD-like protein zf-B_box PF00643.24 ETO27029.1 - 7.1e-07 29.3 9.9 7.1e-07 29.3 9.9 3.6 4 0 0 4 4 4 1 B-box zinc finger zf-C2HC_2 PF13913.6 ETO27029.1 - 8.3e-06 25.6 6.4 8.3e-06 25.6 6.4 3.8 3 0 0 3 3 3 1 zinc-finger of a C2HC-type Sgf11 PF08209.11 ETO27029.1 - 0.012 15.2 1.6 0.012 15.2 1.6 3.6 3 1 0 3 3 3 0 Sgf11 (transcriptional regulation protein) zf-C2H2_3rep PF18868.1 ETO27029.1 - 0.018 15.7 5.5 0.018 15.7 5.5 3.3 2 1 1 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf_UBZ PF18439.1 ETO27029.1 - 0.16 11.6 0.2 0.16 11.6 0.2 4.3 4 1 1 5 5 5 0 Ubiquitin-Binding Zinc Finger DUF365 PF04033.12 ETO27029.1 - 0.48 10.7 3.3 0.69 10.2 1.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF365) HTH_17 PF12728.7 ETO27029.1 - 1.4 9.2 4.9 4.5 7.5 0.1 2.5 2 0 0 2 2 2 0 Helix-turn-helix domain Hema_HEFG PF02710.14 ETO27029.1 - 2.4 8.4 7.6 0.15 12.3 0.8 2.2 2 0 0 2 2 2 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein C1_4 PF07975.12 ETO27029.1 - 3 8.2 13.7 0.54 10.5 4.6 3.6 3 0 0 3 3 3 0 TFIIH C1-like domain ZZ PF00569.17 ETO27029.1 - 8.2 6.3 21.4 0.6 10.0 7.8 3.8 5 0 0 5 5 5 0 Zinc finger, ZZ type Atg14 PF10186.9 ETO27030.1 - 3.5e-06 26.3 0.7 5.7e-06 25.6 0.7 1.3 1 1 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Phage_T7_Capsid PF05396.11 ETO27030.1 - 0.0074 16.6 0.3 0.012 16.0 0.3 1.2 1 0 0 1 1 1 1 Phage T7 capsid assembly protein cwf18 PF08315.12 ETO27030.1 - 0.0094 16.6 0.1 0.015 15.9 0.0 1.5 2 0 0 2 2 2 1 cwf18 pre-mRNA splicing factor DUF2615 PF11027.8 ETO27031.1 - 0.00035 20.7 1.5 0.0011 19.1 0.6 2.1 2 0 0 2 2 2 1 Protein of unknown function (DUF2615) Glucos_trans_II PF14264.6 ETO27031.1 - 0.0039 16.6 0.3 0.0052 16.2 0.3 1.1 1 0 0 1 1 1 1 Glucosyl transferase GtrII LAP1C PF05609.12 ETO27031.1 - 0.0043 16.2 1.3 0.0043 16.2 1.3 1.4 1 1 1 2 2 2 1 Lamina-associated polypeptide 1C (LAP1C) Orf78 PF06024.12 ETO27031.1 - 0.046 14.0 2.5 0.046 14.0 2.5 2.3 2 0 0 2 2 2 0 Orf78 (ac78) DUF3139 PF11337.8 ETO27031.1 - 0.093 13.4 5.6 0.48 11.1 0.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Pox_EPC_I2-L1 PF12575.8 ETO27031.1 - 0.094 13.0 4.1 0.095 12.9 0.2 2.2 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Shisa PF13908.6 ETO27031.1 - 0.13 12.5 9.3 1.1 9.4 1.2 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Chordopox_A13L PF05961.11 ETO27031.1 - 0.14 12.4 0.3 0.14 12.4 0.3 2.8 3 1 0 3 3 2 0 Chordopoxvirus A13L protein ASFV_J13L PF05568.11 ETO27031.1 - 0.17 11.6 0.1 0.17 11.6 0.1 1.8 2 0 0 2 2 2 0 African swine fever virus J13L protein Plant_vir_prot PF01307.17 ETO27031.1 - 0.24 11.6 1.4 3.6 7.9 0.1 2.3 2 0 0 2 2 2 0 Plant viral movement protein DUF3899 PF13038.6 ETO27031.1 - 0.33 11.5 2.1 0.43 11.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) Peptidase_M56 PF05569.11 ETO27031.1 - 0.38 9.9 7.0 1.2 8.3 0.7 2.1 1 1 1 2 2 2 0 BlaR1 peptidase M56 DUF3112 PF11309.8 ETO27031.1 - 0.56 9.6 10.6 1.5 8.2 10.6 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) Baculo_11_kDa PF06143.11 ETO27031.1 - 1.7 8.3 12.1 2.4 7.8 3.0 2.3 2 0 0 2 2 2 0 Baculovirus 11 kDa family ETRAMP PF09716.10 ETO27031.1 - 1.7 8.7 6.3 2.9 8.0 5.2 1.9 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF3169 PF11368.8 ETO27031.1 - 2.1 7.8 10.8 4.5 6.7 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3169) DUF3671 PF12420.8 ETO27031.1 - 3.6 7.7 9.7 26 4.9 9.6 2.1 1 1 1 2 2 2 0 Protein of unknown function EphA2_TM PF14575.6 ETO27031.1 - 4.1 8.4 10.2 8.5 7.3 1.1 2.7 1 1 1 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain Ribosomal_L7Ae PF01248.26 ETO27032.1 - 8.6e-26 89.5 0.1 1.1e-25 89.2 0.1 1.1 1 0 0 1 1 1 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family RNase_P_pop3 PF08228.11 ETO27032.1 - 5.3e-05 23.3 0.0 5.3e-05 23.3 0.0 1.1 1 0 0 1 1 1 1 RNase P subunit Pop3 PELOTA_1 PF15608.6 ETO27032.1 - 0.0076 16.1 0.0 0.01 15.7 0.0 1.2 1 0 0 1 1 1 1 PELOTA RNA binding domain Adenosine_kin PF04008.14 ETO27032.1 - 0.025 14.4 0.0 0.032 14.0 0.0 1.1 1 0 0 1 1 1 0 Adenosine specific kinase VPS13 PF16908.5 ETO27034.1 - 2.2e-22 80.0 7.4 2.8e-11 43.7 0.1 2.5 2 0 0 2 2 2 2 Vacuolar sorting-associated protein 13, N-terminal DUF4160 PF13711.6 ETO27034.1 - 0.59 10.5 7.9 2.9 8.3 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4160) Pro-NT_NN PF07421.11 ETO27034.1 - 7.7 6.7 10.0 0.44 10.8 0.7 3.0 2 1 1 3 3 3 0 Neurotensin/neuromedin N precursor Phage_Gp23 PF10669.9 ETO27034.1 - 8.3 6.8 10.6 0.096 13.0 1.0 2.5 2 1 1 3 3 3 0 Protein gp23 (Bacteriophage A118) WD40 PF00400.32 ETO27035.1 - 1.4e-19 70.0 17.5 0.00039 21.2 0.0 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat Ank_4 PF13637.6 ETO27036.1 - 0.0027 18.2 0.2 0.0091 16.6 0.1 2.1 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO27036.1 - 0.0087 16.6 2.7 0.011 16.3 1.4 1.9 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) VIT1 PF01988.19 ETO27036.1 - 0.056 13.3 1.3 0.1 12.4 1.3 1.3 1 1 0 1 1 1 0 VIT family FAT PF02259.23 ETO27036.1 - 0.15 11.2 5.0 0.046 12.9 1.3 1.7 1 1 1 2 2 2 0 FAT domain HSP70 PF00012.20 ETO27037.1 - 0.00071 17.9 0.0 0.00089 17.6 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein Phage_Nu1 PF07471.12 ETO27037.1 - 0.079 12.7 0.0 0.094 12.5 0.0 1.2 1 0 0 1 1 1 0 Phage DNA packaging protein Nu1 DUF3328 PF11807.8 ETO27037.1 - 0.083 12.7 0.2 0.74 9.6 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF3328) FixQ PF05545.11 ETO27037.1 - 0.18 11.8 0.1 0.39 10.7 0.1 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF4750 PF15938.5 ETO27037.1 - 0.22 11.2 2.9 0.45 10.2 2.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4750) Shisa PF13908.6 ETO27037.1 - 1.9 8.7 6.3 11 6.3 1.5 2.1 1 1 1 2 2 2 0 Wnt and FGF inhibitory regulator Orf78 PF06024.12 ETO27037.1 - 2.5 8.5 8.9 1.7e+02 2.6 8.9 2.1 1 1 0 1 1 1 0 Orf78 (ac78) ETRAMP PF09716.10 ETO27037.1 - 4.1 7.5 11.2 0.72 9.9 1.2 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO27039.1 - 8.8e-36 121.3 21.4 1.1e-06 29.2 0.2 8.0 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27039.1 - 1.1e-13 51.3 0.5 0.027 14.8 0.0 4.8 4 2 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27039.1 - 2e-05 23.5 12.1 0.015 14.0 0.1 4.9 2 2 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO27039.1 - 2.6e-05 23.7 3.2 0.0056 16.0 0.1 3.5 2 2 2 4 4 4 2 WD40-like domain BBS2_Mid PF14783.6 ETO27039.1 - 0.03 14.4 0.9 31 4.7 0.0 4.3 3 2 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region V_ATPase_I PF01496.19 ETO27039.1 - 0.033 12.1 3.2 0.034 12.1 3.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF1541 PF07563.11 ETO27039.1 - 0.18 11.7 0.6 6.7 6.7 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) Peptidase_U49 PF10463.9 ETO27039.1 - 0.2 11.4 3.8 0.31 10.8 3.8 1.2 1 0 0 1 1 1 0 Peptidase U49 DUF5327 PF17261.2 ETO27039.1 - 0.22 12.3 10.0 0.4 11.4 10.0 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5327) SKA1 PF07160.12 ETO27039.1 - 0.23 11.3 9.7 0.31 10.9 9.7 1.2 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF4200 PF13863.6 ETO27039.1 - 0.37 11.2 11.4 0.75 10.2 11.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4200) FAM76 PF16046.5 ETO27039.1 - 0.4 10.0 14.9 0.45 9.8 13.2 1.8 1 1 1 2 2 2 0 FAM76 protein Jnk-SapK_ap_N PF09744.9 ETO27039.1 - 2.6 8.2 12.1 3.8 7.7 12.1 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 RP-C_C PF11800.8 ETO27039.1 - 5.5 7.0 5.8 8.2 6.5 5.8 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Alpha-amylase PF00128.24 ETO27040.1 - 8.8e-40 137.3 0.0 3.2e-18 66.4 0.0 3.1 2 1 1 3 3 3 3 Alpha amylase, catalytic domain Trefoil PF00088.18 ETO27040.1 - 9.6e-12 44.6 15.5 1.1e-11 44.4 13.0 2.3 2 0 0 2 2 2 1 Trefoil (P-type) domain DUF1966 PF09260.11 ETO27040.1 - 0.0038 17.5 0.0 0.0078 16.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1966) Trypan_PARP PF05887.11 ETO27041.1 - 0.0018 18.3 1.3 0.0034 17.4 1.3 1.4 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) Neisseria_TspB PF05616.13 ETO27041.1 - 0.013 14.0 19.3 0.021 13.3 19.3 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein DUF5097 PF17020.5 ETO27041.1 - 0.14 12.5 0.2 0.24 11.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5097) SPX PF03105.19 ETO27041.1 - 0.14 12.1 12.2 0.17 11.7 12.2 1.3 1 0 0 1 1 1 0 SPX domain CAP_GLY PF01302.25 ETO27042.1 - 0.001 19.0 0.1 0.0021 18.1 0.1 1.5 1 0 0 1 1 1 1 CAP-Gly domain Borealin PF10512.9 ETO27043.1 - 0.088 12.8 0.0 0.12 12.3 0.0 1.3 1 0 0 1 1 1 0 Cell division cycle-associated protein 8 C2 PF00168.30 ETO27044.1 - 6.8e-11 42.4 2.4 5e-06 26.7 0.0 4.0 5 0 0 5 5 5 2 C2 domain PH PF00169.29 ETO27045.1 - 3.9e-11 43.4 0.7 9.7e-11 42.1 0.2 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO27045.1 - 0.00011 22.5 0.1 0.00011 22.5 0.1 2.3 3 0 0 3 3 3 1 Pleckstrin homology domain PH_8 PF15409.6 ETO27045.1 - 0.00059 20.1 0.5 1.1 9.6 0.0 3.0 1 1 0 2 2 2 2 Pleckstrin homology domain Ras PF00071.22 ETO27045.1 - 0.01 15.4 0.1 0.033 13.8 0.0 1.9 2 0 0 2 2 2 0 Ras family PH_13 PF16652.5 ETO27045.1 - 0.016 15.0 0.0 0.13 12.0 0.0 2.2 2 0 0 2 2 2 0 Pleckstrin homology domain DUF3105 PF11303.8 ETO27045.1 - 0.13 12.5 0.3 5.1 7.3 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3105) eIF2A PF08662.11 ETO27046.1 - 3.3e-16 59.7 1.7 6.3e-06 26.2 0.1 4.7 3 1 0 4 4 4 3 Eukaryotic translation initiation factor eIF2A ANAPC4_WD40 PF12894.7 ETO27046.1 - 0.00059 20.1 0.4 0.24 11.7 0.0 4.5 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO27046.1 - 0.0095 16.8 3.0 1.4e+02 3.6 0.0 5.8 5 2 0 5 5 5 0 WD domain, G-beta repeat OspE PF02471.17 ETO27046.1 - 0.024 14.8 0.5 0.25 11.6 0.1 2.7 2 0 0 2 2 2 0 Borrelia outer surface protein E FAM76 PF16046.5 ETO27047.1 - 0.0021 17.4 11.6 0.0028 17.0 11.6 1.1 1 0 0 1 1 1 1 FAM76 protein SID-1_RNA_chan PF13965.6 ETO27047.1 - 0.01 14.3 2.2 0.012 14.1 2.2 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Astro_capsid_p PF12226.8 ETO27047.1 - 0.057 12.6 6.9 0.079 12.1 6.9 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein CENP-B_dimeris PF09026.10 ETO27047.1 - 0.18 12.2 12.2 0.37 11.2 12.2 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pap_E4 PF02711.14 ETO27047.1 - 0.22 12.5 2.3 0.21 12.5 0.4 1.9 2 1 0 2 2 2 0 E4 protein TRAP_alpha PF03896.16 ETO27047.1 - 0.64 9.2 11.7 1 8.5 11.7 1.4 1 1 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CLN3 PF02487.17 ETO27047.1 - 0.7 8.9 6.5 0.29 10.2 4.4 1.4 1 1 1 2 2 2 0 CLN3 protein DNA_pol_phi PF04931.13 ETO27047.1 - 0.78 7.8 19.6 0.86 7.6 19.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO27047.1 - 1.2 7.8 9.3 1.2 7.8 9.3 1.2 1 0 0 1 1 1 0 Presenilin CSG2 PF16965.5 ETO27047.1 - 1.7 7.5 2.8 1.8 7.4 2.8 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 ETO27047.1 - 2.4 7.3 7.7 2.6 7.2 7.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO27047.1 - 4.7 5.4 21.9 5.6 5.1 21.9 1.1 1 0 0 1 1 1 0 CDC45-like protein O-antigen_lig PF13425.6 ETO27047.1 - 6.2 5.5 7.0 7.4 5.2 7.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Sporozoite_P67 PF05642.11 ETO27047.1 - 6.7 4.7 9.2 6.8 4.6 9.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NPR3 PF03666.13 ETO27047.1 - 8.2 5.1 14.7 9.5 4.9 14.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ras PF00071.22 ETO27050.1 - 2e-07 30.8 0.1 2.8e-07 30.3 0.1 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO27050.1 - 5e-07 30.0 0.0 8.1e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Seryl_tRNA_N PF02403.22 ETO27052.1 - 1.6e-11 44.4 15.6 1.1e-10 41.7 1.6 2.5 2 1 0 2 2 2 2 Seryl-tRNA synthetase N-terminal domain CENP-F_leu_zip PF10473.9 ETO27052.1 - 0.085 12.9 14.7 0.15 12.1 7.0 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF948 PF06103.11 ETO27052.1 - 0.11 12.7 1.1 0.64 10.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 ETO27052.1 - 0.35 11.5 3.5 0.39 11.4 0.1 2.2 2 0 0 2 2 2 0 SlyX DUF4446 PF14584.6 ETO27052.1 - 1.8 8.5 7.9 6.7 6.7 0.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) AAA_23 PF13476.6 ETO27052.1 - 3.5 8.1 11.8 5 7.6 11.8 1.2 1 0 0 1 1 1 0 AAA domain Citrate_ly_lig PF08218.11 ETO27054.1 - 0.061 13.0 0.0 0.078 12.6 0.0 1.1 1 0 0 1 1 1 0 Citrate lyase ligase C-terminal domain DUF4458 PF14660.6 ETO27055.1 - 0.089 13.0 0.7 0.19 11.9 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4458) TAN PF11640.8 ETO27055.1 - 0.13 12.4 6.6 0.07 13.2 1.9 2.5 3 1 0 3 3 3 0 Telomere-length maintenance and DNA damage repair ADK PF00406.22 ETO27056.1 - 2.7e-24 86.0 0.0 4.8e-24 85.2 0.0 1.4 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETO27056.1 - 5.8e-07 30.0 0.0 1.6e-06 28.6 0.0 1.8 2 0 0 2 2 1 1 AAA domain ADK_lid PF05191.14 ETO27056.1 - 0.0011 18.9 5.1 0.0041 17.1 5.1 2.0 1 1 0 1 1 1 1 Adenylate kinase, active site lid AAA_18 PF13238.6 ETO27056.1 - 0.0022 18.5 0.7 0.0043 17.6 0.0 2.0 3 0 0 3 3 2 1 AAA domain RNA_helicase PF00910.22 ETO27056.1 - 0.0025 18.2 0.0 0.0078 16.6 0.0 1.9 2 0 0 2 2 2 1 RNA helicase Cytidylate_kin PF02224.18 ETO27056.1 - 0.0091 15.7 0.0 0.019 14.7 0.0 1.7 1 1 0 1 1 1 1 Cytidylate kinase AAA_33 PF13671.6 ETO27056.1 - 0.025 14.7 0.0 0.097 12.8 0.0 2.1 1 1 0 2 2 2 0 AAA domain DUF1759 PF03564.15 ETO27056.1 - 0.028 14.3 0.1 0.061 13.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) AAA_16 PF13191.6 ETO27056.1 - 0.053 13.9 0.0 0.099 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain Mg_chelatase PF01078.21 ETO27056.1 - 0.058 12.8 0.0 0.095 12.1 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Symplekin_C PF12295.8 ETO27056.1 - 0.1 12.7 0.0 8.8 6.4 0.0 2.5 1 1 1 2 2 2 0 Symplekin tight junction protein C terminal AAA PF00004.29 ETO27056.1 - 0.11 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) H2O2_YaaD PF03883.14 ETO27056.1 - 0.15 11.5 0.0 0.27 10.7 0.0 1.4 1 0 0 1 1 1 0 Peroxide stress protein YaaA NTP_transf_5 PF14907.6 ETO27056.1 - 0.18 11.4 0.0 0.33 10.5 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised nucleotidyltransferase zf-ACC PF17848.1 ETO27056.1 - 0.22 11.7 3.4 0.37 10.9 0.1 2.6 2 0 0 2 2 2 0 Acetyl-coA carboxylase zinc finger domain Hydin_ADK PF17213.3 ETO27056.1 - 0.41 10.9 2.7 3 8.1 0.0 2.8 3 1 0 3 3 3 0 Hydin Adenylate kinase-like domain Gin PF10764.9 ETO27056.1 - 1.5 8.9 5.4 5.1 7.1 0.3 2.6 2 0 0 2 2 2 0 Inhibitor of sigma-G Gin Tubulin_C PF03953.17 ETO27058.1 - 9.1e-38 129.3 0.0 1.5e-37 128.6 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO27058.1 - 2.4e-36 125.8 0.0 4e-36 125.1 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain FAD_binding_2 PF00890.24 ETO27059.1 - 2.1e-70 237.9 0.0 2.8e-70 237.5 0.0 1.2 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETO27059.1 - 2e-09 37.5 0.8 9.8e-09 35.2 0.4 2.3 2 1 0 2 2 2 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ETO27059.1 - 7.5e-08 32.1 0.0 1.3e-07 31.4 0.0 1.4 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO27059.1 - 3.1e-05 23.3 2.1 0.00017 20.9 2.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETO27059.1 - 8.2e-05 21.9 2.3 0.00026 20.2 0.3 2.4 3 0 0 3 3 3 1 Glucose inhibited division protein A NAD_binding_8 PF13450.6 ETO27059.1 - 0.00021 21.5 0.6 0.00021 21.5 0.6 2.3 3 0 0 3 3 2 1 NAD(P)-binding Rossmann-like domain FAD_binding_3 PF01494.19 ETO27059.1 - 0.00038 19.8 0.0 0.00054 19.3 0.0 1.3 1 0 0 1 1 1 1 FAD binding domain Thi4 PF01946.17 ETO27059.1 - 0.0008 18.7 0.2 0.0051 16.1 0.1 2.1 2 0 0 2 2 2 1 Thi4 family HI0933_like PF03486.14 ETO27059.1 - 0.001 17.9 0.5 0.001 17.9 0.5 2.2 3 0 0 3 3 3 1 HI0933-like protein Pyr_redox_3 PF13738.6 ETO27059.1 - 0.0037 16.6 0.6 0.0084 15.4 0.2 1.7 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase GMC_oxred_N PF00732.19 ETO27059.1 - 0.044 13.1 0.6 0.1 12.0 0.0 1.7 2 0 0 2 2 2 0 GMC oxidoreductase SBP_bac_1 PF01547.25 ETO27059.1 - 0.059 13.3 0.9 0.21 11.5 0.2 2.0 2 0 0 2 2 2 0 Bacterial extracellular solute-binding protein Pyr_redox PF00070.27 ETO27059.1 - 0.44 11.1 7.3 0.13 12.8 0.6 2.7 3 0 0 3 3 3 0 Pyridine nucleotide-disulphide oxidoreductase Tubulin PF00091.25 ETO27060.1 - 1.2e-59 201.9 0.0 6.2e-58 196.3 0.0 2.3 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO27060.1 - 6.7e-38 129.7 0.0 1.1e-37 129.0 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Lipase_3 PF01764.25 ETO27060.1 - 0.029 14.2 0.0 0.052 13.4 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) DivIVA PF05103.13 ETO27063.1 - 0.035 14.2 1.8 0.036 14.2 0.3 1.7 2 0 0 2 2 2 0 DivIVA protein DUF2383 PF09537.10 ETO27063.1 - 0.073 13.4 0.1 0.16 12.3 0.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF2383) Corazonin PF17308.2 ETO27064.1 - 0.097 13.0 4.9 0.16 12.4 4.9 1.3 1 0 0 1 1 1 0 Pro-corazonin Orf78 PF06024.12 ETO27064.1 - 0.14 12.5 0.4 0.23 11.8 0.4 1.3 1 0 0 1 1 1 0 Orf78 (ac78) Glyco_transf_22 PF03901.17 ETO27065.1 - 4.8e-75 253.4 48.1 5.8e-75 253.1 48.1 1.1 1 0 0 1 1 1 1 Alg9-like mannosyltransferase family Tna_leader PF08053.11 ETO27065.1 - 0.42 10.6 3.0 6.5 6.9 0.1 3.1 2 0 0 2 2 2 0 Tryptophanase operon leader peptide NCA2 PF08637.10 ETO27067.1 - 0.0013 18.0 3.9 0.0014 17.8 1.8 1.9 1 1 1 2 2 2 1 ATP synthase regulation protein NCA2 TGFb_propeptide PF00688.18 ETO27067.1 - 0.05 13.3 0.3 0.077 12.7 0.3 1.3 1 0 0 1 1 1 0 TGF-beta propeptide PGP_phosphatase PF09419.10 ETO27069.1 - 0.049 13.3 0.1 0.077 12.6 0.1 1.2 1 0 0 1 1 1 0 Mitochondrial PGP phosphatase LemA PF04011.12 ETO27070.1 - 0.054 13.4 5.1 0.45 10.4 0.0 2.3 2 0 0 2 2 2 0 LemA family DUF775 PF05603.12 ETO27070.1 - 0.089 12.3 3.8 0.16 11.5 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF775) DUF5582 PF17819.1 ETO27070.1 - 0.96 9.9 7.8 1.9 9.0 7.8 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5582) CAP_GLY PF01302.25 ETO27071.1 - 1.8e-21 75.9 0.4 3.5e-21 75.0 0.4 1.5 1 0 0 1 1 1 1 CAP-Gly domain DnaJ_CXXCXGXG PF00684.19 ETO27071.1 - 0.00039 20.7 2.2 0.00094 19.5 2.2 1.7 1 0 0 1 1 1 1 DnaJ central domain TackOD1 PF18551.1 ETO27071.1 - 0.015 15.0 6.0 0.033 13.9 6.0 1.5 1 0 0 1 1 1 0 Thaumarchaeal output domain 1 ZZ PF00569.17 ETO27071.1 - 0.21 11.4 6.6 0.6 10.0 6.6 1.9 1 1 0 1 1 1 0 Zinc finger, ZZ type zf-NADH-PPase PF09297.11 ETO27071.1 - 3.7 7.3 10.7 7.4 6.3 0.2 3.7 3 1 1 4 4 4 0 NADH pyrophosphatase zinc ribbon domain Ribosomal_S27e PF01667.17 ETO27071.1 - 5.4 6.8 6.8 14 5.4 3.1 2.4 2 0 0 2 2 2 0 Ribosomal protein S27 Menin PF05053.13 ETO27072.1 - 0.0079 14.6 4.3 0.009 14.4 4.3 1.0 1 0 0 1 1 1 1 Menin Hydrolase_3 PF08282.12 ETO27074.1 - 0.0048 16.7 8.0 0.0048 16.7 8.0 2.3 1 1 1 2 2 2 1 haloacid dehalogenase-like hydrolase DUF547 PF04784.14 ETO27074.1 - 0.0059 16.6 0.1 0.015 15.3 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function, DUF547 Mucin PF01456.17 ETO27074.1 - 4.9 7.1 8.6 15 5.5 8.6 1.8 1 1 0 1 1 1 0 Mucin-like glycoprotein Bax1-I PF01027.20 ETO27075.1 - 0.0018 18.1 3.1 0.0031 17.4 3.1 1.3 1 0 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 DUF1129 PF06570.11 ETO27075.1 - 0.0083 15.6 0.3 0.021 14.3 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF1129) RcpB PF16971.5 ETO27075.1 - 0.035 14.0 0.8 0.073 13.0 0.8 1.5 1 0 0 1 1 1 0 Rough colony protein B, tight adherence - tad - subunit Guanylate_cyc PF00211.20 ETO27076.1 - 1.4e-12 47.6 0.0 2.8e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain PAPA-1 PF04795.12 ETO27076.1 - 0.02 15.7 3.0 0.11 13.3 2.6 2.3 2 0 0 2 2 2 0 PAPA-1-like conserved region NUP50 PF08911.11 ETO27077.1 - 0.15 12.7 0.2 0.15 12.7 0.2 4.7 5 1 0 5 5 5 0 NUP50 (Nucleoporin 50 kDa) ATP-sulfurylase PF01747.17 ETO27078.1 - 2.3e-75 252.7 0.2 1.3e-74 250.2 0.2 1.9 1 1 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 ETO27078.1 - 1.6e-34 119.0 0.0 3.3e-34 118.1 0.0 1.4 1 0 0 1 1 1 1 Adenylylsulphate kinase PUA_2 PF14306.6 ETO27078.1 - 8.1e-13 48.3 0.1 1.3e-12 47.6 0.1 1.3 1 0 0 1 1 1 1 PUA-like domain KTI12 PF08433.10 ETO27078.1 - 1e-05 25.2 0.0 1.6e-05 24.5 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 AAA_18 PF13238.6 ETO27078.1 - 0.00041 20.9 0.0 0.0012 19.4 0.0 1.8 2 0 0 2 2 2 1 AAA domain Zeta_toxin PF06414.12 ETO27078.1 - 0.0032 16.8 0.0 0.0053 16.1 0.0 1.3 1 0 0 1 1 1 1 Zeta toxin AAA_16 PF13191.6 ETO27078.1 - 0.0049 17.3 0.0 0.0074 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO27078.1 - 0.0065 16.2 0.0 0.014 15.1 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain MeaB PF03308.16 ETO27078.1 - 0.012 14.6 0.0 0.02 13.9 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_33 PF13671.6 ETO27078.1 - 0.012 15.7 0.0 0.024 14.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETO27078.1 - 0.023 14.8 0.0 0.039 14.1 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_22 PF13401.6 ETO27078.1 - 0.047 14.0 0.0 0.15 12.3 0.0 1.7 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ETO27078.1 - 0.075 12.2 0.0 0.12 11.5 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit AAA_28 PF13521.6 ETO27078.1 - 0.11 12.7 0.0 0.22 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain T2SSE PF00437.20 ETO27078.1 - 0.16 11.0 0.0 0.27 10.3 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein NAD_kinase PF01513.21 ETO27079.1 - 7.4e-12 45.1 0.0 1.3e-11 44.3 0.0 1.3 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ETO27079.1 - 0.0035 17.0 0.0 0.0066 16.1 0.0 1.5 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain ATP-synt_C PF00137.21 ETO27079.1 - 0.076 13.4 0.6 0.12 12.7 0.6 1.3 1 0 0 1 1 1 0 ATP synthase subunit C PRP38 PF03371.15 ETO27081.1 - 2.4e-53 180.5 1.0 2.4e-53 180.5 1.0 1.4 2 0 0 2 2 2 1 PRP38 family GHL6 PF14871.6 ETO27082.1 - 0.034 14.3 0.0 5.7 7.1 0.0 2.2 1 1 1 2 2 2 0 Hypothetical glycosyl hydrolase 6 Methyltr_RsmB-F PF01189.17 ETO27083.1 - 1.8e-22 79.9 0.2 3.3e-16 59.5 0.0 2.5 2 1 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 ETO27083.1 - 0.0045 16.8 0.0 2 8.2 0.0 2.3 2 0 0 2 2 2 2 Methyltransferase domain Methyltransf_25 PF13649.6 ETO27083.1 - 0.0093 16.6 0.0 0.072 13.8 0.0 2.4 2 2 1 3 3 3 1 Methyltransferase domain FKBP_C PF00254.28 ETO27086.1 - 7.5e-19 67.9 0.0 1.3e-18 67.1 0.0 1.5 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase QSregVF PF13652.6 ETO27086.1 - 0.096 12.7 0.1 0.15 12.1 0.1 1.3 1 0 0 1 1 1 0 Putative quorum-sensing-regulated virulence factor RecR PF02132.15 ETO27087.1 - 0.092 12.3 3.2 3.3 7.3 0.4 2.6 2 1 0 2 2 2 0 RecR protein CPSase_L_D3 PF02787.19 ETO27088.1 - 0.12 12.7 0.8 0.21 12.0 0.8 1.4 1 0 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain SPG48 PF14764.6 ETO27089.1 - 0.0037 17.7 0.6 0.0047 17.4 0.1 1.5 2 0 0 2 2 2 1 AP-5 complex subunit, vesicle trafficking MAR_sialic_bdg PF10564.9 ETO27089.1 - 0.0084 16.1 0.8 0.015 15.3 0.8 1.4 1 0 0 1 1 1 1 Sialic-acid binding micronemal adhesive repeat zf-TRM13_CCCH PF11722.8 ETO27089.1 - 0.06 13.1 5.3 0.1 12.4 5.3 1.4 1 0 0 1 1 1 0 CCCH zinc finger in TRM13 protein Ycf70 PF17382.2 ETO27089.1 - 2.8 8.4 5.6 1 9.8 0.5 2.1 1 1 0 2 2 2 0 Uncharacterized Ycf70-like TSSC4 PF15264.6 ETO27090.1 - 0.01 16.1 3.8 0.26 11.6 0.9 2.2 2 0 0 2 2 2 0 Tumour suppressing sub-chromosomal transferable candidate 4 BNR_assoc_N PF14873.6 ETO27090.1 - 0.039 13.6 0.7 0.039 13.6 0.7 1.9 2 0 0 2 2 2 0 N-terminal domain of BNR-repeat neuraminidase AARP2CN PF08142.12 ETO27090.1 - 0.085 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 AARP2CN (NUC121) domain IncFII_repA PF02387.15 ETO27090.1 - 0.45 9.7 5.4 6.1 6.0 1.8 2.2 2 1 0 2 2 2 0 IncFII RepA protein family DUF4136 PF13590.6 ETO27090.1 - 1.9 9.1 4.5 1.2 9.7 0.8 2.5 2 2 1 3 3 3 0 Domain of unknown function (DUF4136) RPEL PF02755.15 ETO27090.1 - 3.4 7.5 7.5 1.5 8.6 0.1 3.6 4 0 0 4 4 4 0 RPEL repeat Metallophos PF00149.28 ETO27091.1 - 0.0047 17.5 1.2 0.0065 17.0 1.2 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Pax2_C PF12403.8 ETO27094.1 - 0.0011 19.0 0.3 0.0028 17.7 0.3 1.6 1 0 0 1 1 1 1 Paired-box protein 2 C terminal SIR2 PF02146.17 ETO27095.1 - 6.2e-36 124.0 0.0 7e-36 123.8 0.0 1.0 1 0 0 1 1 1 1 Sir2 family DNA_ligase_ZBD PF03119.16 ETO27095.1 - 0.029 14.4 2.0 0.053 13.6 0.6 2.1 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain TPP_enzyme_M PF00205.22 ETO27095.1 - 0.17 11.6 0.0 0.22 11.2 0.0 1.2 1 0 0 1 1 1 0 Thiamine pyrophosphate enzyme, central domain DZR PF12773.7 ETO27095.1 - 0.21 11.6 4.2 0.48 10.5 4.2 1.6 1 0 0 1 1 1 0 Double zinc ribbon zf-ribbon_3 PF13248.6 ETO27095.1 - 0.57 9.7 6.2 0.41 10.1 2.4 2.3 2 0 0 2 2 2 0 zinc-ribbon domain Auto_anti-p27 PF06677.12 ETO27095.1 - 9.8 6.4 8.0 2.4 8.4 1.8 2.5 3 0 0 3 3 3 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) HSBP1 PF06825.12 ETO27096.1 - 0.053 13.4 0.0 0.11 12.4 0.0 1.5 1 0 0 1 1 1 0 Heat shock factor binding protein 1 PH PF00169.29 ETO27098.1 - 9.4e-10 39.0 1.1 3.1e-09 37.3 0.1 2.1 2 1 0 2 2 2 1 PH domain PH_2 PF08458.10 ETO27098.1 - 0.014 15.7 0.1 0.032 14.6 0.1 1.6 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_11 PF15413.6 ETO27098.1 - 0.84 10.1 3.9 6.3 7.3 3.8 2.6 1 1 0 1 1 1 0 Pleckstrin homology domain Acetyltransf_1 PF00583.25 ETO27100.1 - 3.7e-09 36.8 0.0 8.3e-09 35.7 0.0 1.7 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO27100.1 - 2e-08 34.5 0.0 4.5e-08 33.4 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETO27100.1 - 4.1e-05 23.7 0.0 8e-05 22.7 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO27100.1 - 0.00021 21.2 0.0 0.00085 19.3 0.0 2.0 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETO27100.1 - 0.006 16.7 0.0 0.018 15.2 0.0 1.8 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase FR47 PF08445.10 ETO27100.1 - 0.014 15.3 0.0 0.044 13.7 0.0 1.7 2 0 0 2 2 2 0 FR47-like protein Acetyltransf_3 PF13302.7 ETO27100.1 - 0.061 14.0 0.0 0.093 13.4 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain SIR2 PF02146.17 ETO27101.1 - 0.00011 22.2 0.3 0.0012 18.8 0.0 2.2 2 0 0 2 2 2 1 Sir2 family zf-UBR PF02207.20 ETO27101.1 - 0.078 13.2 1.2 0.14 12.3 1.2 1.5 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) ZZ PF00569.17 ETO27101.1 - 0.27 11.1 4.8 1.3 8.9 4.8 2.1 1 1 0 1 1 1 0 Zinc finger, ZZ type C1_2 PF03107.16 ETO27101.1 - 4.9 7.5 6.9 0.61 10.4 2.4 1.9 2 1 0 2 2 2 0 C1 domain WD40 PF00400.32 ETO27102.1 - 2.9e-32 110.2 5.2 1.4e-08 35.3 0.1 5.3 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27102.1 - 1.3e-19 70.3 0.4 0.00011 22.4 0.0 4.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27102.1 - 8.5e-09 34.8 0.3 0.088 11.8 0.0 4.7 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO27102.1 - 1.5e-07 31.5 0.0 0.0083 16.0 0.0 3.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO27102.1 - 3.1e-05 23.8 5.3 1.9 8.5 0.8 4.9 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO27102.1 - 7.7e-05 21.5 0.1 0.11 11.2 0.0 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO27102.1 - 0.00013 20.6 0.1 0.24 9.9 0.0 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO27102.1 - 0.00098 18.5 0.1 0.31 10.3 0.1 2.3 1 1 0 2 2 2 2 WD40-like domain Utp8 PF10395.9 ETO27102.1 - 0.023 13.2 0.1 0.15 10.6 0.0 1.9 1 1 0 2 2 2 0 Utp8 family Proteasome_A_N PF10584.9 ETO27102.1 - 8.7 6.1 10.5 30 4.4 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Vma12 PF11712.8 ETO27103.1 - 0.00012 22.2 1.3 0.00023 21.3 1.3 1.5 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Isochorismatase PF00857.20 ETO27104.1 - 6.4e-20 72.1 0.1 7.7e-20 71.8 0.1 1.1 1 0 0 1 1 1 1 Isochorismatase family DIL PF01843.19 ETO27105.1 - 1.5e-10 41.3 3.9 1.5e-10 41.3 3.9 2.6 4 0 0 4 4 4 1 DIL domain YL1 PF05764.13 ETO27106.1 - 0.0012 19.0 16.7 0.0018 18.5 16.7 1.2 1 0 0 1 1 1 1 YL1 nuclear protein Menin PF05053.13 ETO27106.1 - 0.0023 16.4 14.0 0.0028 16.1 14.0 1.1 1 0 0 1 1 1 1 Menin GREB1 PF15782.5 ETO27106.1 - 1.4 6.0 10.4 1.6 5.7 10.4 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ORC_WH_C PF18137.1 ETO27106.1 - 5.7 7.0 15.4 2.9 8.0 7.8 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal CDC45 PF02724.14 ETO27107.1 - 0.096 11.0 17.5 0.14 10.4 17.5 1.2 1 0 0 1 1 1 0 CDC45-like protein FAD_oxidored PF12831.7 ETO27107.1 - 7.9 5.7 5.6 11 5.2 5.6 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase Tubulin-binding PF00418.19 ETO27109.1 - 0.0077 16.2 3.7 0.18 11.9 0.1 3.3 3 0 0 3 3 3 2 Tau and MAP protein, tubulin-binding repeat Spaetzle PF16077.5 ETO27109.1 - 0.02 15.4 0.9 0.02 15.4 0.9 2.2 2 0 0 2 2 2 0 Spaetzle C2 PF00168.30 ETO27111.1 - 1.3e-19 70.3 0.0 2.1e-19 69.7 0.0 1.3 1 0 0 1 1 1 1 C2 domain Roughex PF06020.11 ETO27111.1 - 0.87 8.6 6.5 1.1 8.3 6.5 1.1 1 0 0 1 1 1 0 Drosophila roughex protein PBP_sp32 PF07222.12 ETO27111.1 - 7.7 5.9 10.9 11 5.4 10.9 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DSPc PF00782.20 ETO27114.1 - 1.2e-28 99.6 3.1 2.5e-28 98.5 0.5 2.0 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO27114.1 - 2.6e-05 23.9 0.4 3.5e-05 23.5 0.0 1.5 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETO27114.1 - 0.011 16.0 0.1 0.021 15.1 0.1 1.5 1 0 0 1 1 1 0 Rit1 DUSP-like domain zf_UBZ PF18439.1 ETO27114.1 - 0.067 12.8 0.5 0.15 11.7 0.5 1.6 1 0 0 1 1 1 0 Ubiquitin-Binding Zinc Finger Nop14 PF04147.12 ETO27115.1 - 0.00025 19.4 5.3 0.00025 19.4 5.3 2.1 2 0 0 2 2 2 2 Nop14-like family FLYWCH PF04500.16 ETO27115.1 - 0.00041 20.4 4.7 0.056 13.6 0.0 3.1 3 0 0 3 3 3 2 FLYWCH zinc finger domain Pkinase PF00069.25 ETO27117.1 - 8.7e-52 176.1 0.0 1.6e-51 175.2 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27117.1 - 1.6e-35 122.6 0.0 3.7e-35 121.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO27117.1 - 4.2e-06 26.3 0.0 0.00053 19.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like SUIM_assoc PF16619.5 ETO27117.1 - 0.016 15.3 2.9 0.03 14.4 0.8 2.3 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Methyltransf_31 PF13847.6 ETO27118.1 - 1.4e-08 34.6 0.1 2.8e-08 33.7 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO27118.1 - 6.9e-05 23.5 0.0 0.00037 21.2 0.0 2.2 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO27118.1 - 0.00034 20.6 0.1 0.00034 20.6 0.1 2.2 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO27118.1 - 0.0082 16.9 1.1 0.014 16.1 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO27118.1 - 0.056 13.3 0.0 0.15 11.9 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ETO27118.1 - 0.082 12.5 0.0 0.71 9.4 0.0 2.3 1 1 0 1 1 1 0 Methyltransferase small domain DUF3280 PF11684.8 ETO27119.1 - 0.026 15.0 0.4 0.041 14.3 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2380) Staphylokinase PF02821.16 ETO27119.1 - 0.043 14.3 3.6 0.065 13.7 3.5 1.4 1 1 0 1 1 1 0 Staphylokinase/Streptokinase family WD40 PF00400.32 ETO27120.1 - 2.2e-19 69.4 9.2 9.8e-09 35.7 1.0 4.6 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27120.1 - 2e-09 37.6 0.4 0.015 15.6 0.1 4.2 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ETO27120.1 - 0.033 12.7 0.0 0.05 12.1 0.0 1.3 1 0 0 1 1 1 0 Cytochrome D1 heme domain DUF4598 PF15370.6 ETO27121.1 - 0.00019 21.9 0.7 0.00019 21.9 0.7 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4598) Baculo_p24 PF05073.12 ETO27121.1 - 0.009 15.8 0.9 0.01 15.6 0.9 1.1 1 0 0 1 1 1 1 Baculovirus P24 capsid protein FlaC_arch PF05377.11 ETO27121.1 - 0.023 15.1 1.7 0.055 13.9 1.3 1.8 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) Citrate_synt PF00285.21 ETO27122.1 - 1e-30 107.0 0.0 1.4e-30 106.6 0.0 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF4853 PF16145.5 ETO27122.1 - 0.0031 17.7 0.0 0.0052 16.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4853) ABC_tran PF00005.27 ETO27123.1 - 2.3e-16 60.5 0.1 5.3e-16 59.4 0.0 1.6 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ETO27123.1 - 1.2e-05 24.9 0.1 1.4e-05 24.6 0.1 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ETO27123.1 - 5.7e-05 22.1 0.1 6.8e-05 21.8 0.1 1.1 1 0 0 1 1 1 1 Predicted ATPase of the ABC class SbcCD_C PF13558.6 ETO27123.1 - 0.00031 20.9 0.9 0.013 15.7 0.9 2.2 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA PF00004.29 ETO27123.1 - 0.015 15.7 0.1 0.019 15.4 0.1 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) MMR_HSR1 PF01926.23 ETO27124.1 - 3.7e-05 23.8 0.6 3.7e-05 23.8 0.6 2.3 2 1 0 2 2 2 1 50S ribosome-binding GTPase SRP54 PF00448.22 ETO27124.1 - 0.0045 16.6 1.0 0.41 10.2 0.9 2.6 1 1 0 1 1 1 1 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 ETO27124.1 - 0.031 14.2 1.4 0.11 12.4 0.1 2.3 1 1 1 2 2 2 0 RsgA GTPase AAA PF00004.29 ETO27124.1 - 0.033 14.6 0.1 0.12 12.8 0.1 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF839 PF05787.13 ETO27124.1 - 0.099 11.8 0.0 0.11 11.6 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF839) PTPlike_phytase PF14566.6 ETO27124.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.5 3 0 0 3 3 3 0 Inositol hexakisphosphate ABC_tran PF00005.27 ETO27124.1 - 0.14 12.6 3.4 0.11 13.0 1.0 2.3 2 1 0 2 2 2 0 ABC transporter AAA_33 PF13671.6 ETO27124.1 - 0.15 12.3 0.4 0.5 10.5 0.4 1.9 1 1 0 1 1 1 0 AAA domain Lipase_GDSL PF00657.22 ETO27124.1 - 0.2 11.6 1.4 0.51 10.3 0.1 2.3 2 0 0 2 2 2 0 GDSL-like Lipase/Acylhydrolase CDC45 PF02724.14 ETO27128.1 - 0.00018 20.0 1.8 0.00018 20.0 1.8 2.1 2 0 0 2 2 2 2 CDC45-like protein BUD22 PF09073.10 ETO27128.1 - 0.001 18.5 39.7 0.011 15.1 23.8 2.1 2 0 0 2 2 2 2 BUD22 V_ATPase_I PF01496.19 ETO27128.1 - 0.0082 14.1 0.1 0.0082 14.1 0.1 2.4 2 1 0 2 2 2 1 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 ETO27128.1 - 0.027 15.4 0.0 0.027 15.4 0.0 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Mpp10 PF04006.12 ETO27128.1 - 0.031 12.7 32.8 0.019 13.5 5.3 2.1 2 0 0 2 2 2 0 Mpp10 protein DUF913 PF06025.12 ETO27128.1 - 0.04 12.9 0.3 0.04 12.9 0.3 2.4 2 1 0 2 2 2 0 Domain of Unknown Function (DUF913) RRN3 PF05327.11 ETO27128.1 - 1.8 7.0 33.0 0.24 9.9 12.2 2.3 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 Pes-10 PF07149.11 ETO27128.1 - 4.5 6.2 31.2 0.01 14.9 5.4 2.5 2 0 0 2 2 2 0 Pes-10 NAPRTase_C PF17956.1 ETO27129.1 - 0.073 13.5 0.4 0.91 10.0 0.2 2.3 2 0 0 2 2 2 0 Nicotinate phosphoribosyltransferase C-terminal domain CDC45 PF02724.14 ETO27130.1 - 1.1 7.4 13.4 1.2 7.3 13.4 1.0 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO27130.1 - 4.9 6.5 21.3 5.1 6.4 21.3 1.0 1 0 0 1 1 1 0 SDA1 Gti1_Pac2 PF09729.9 ETO27130.1 - 6.4 6.8 13.6 7.9 6.5 13.6 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family SLC12 PF03522.15 ETO27130.1 - 7.9 5.4 13.1 8.2 5.3 13.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Nop14 PF04147.12 ETO27130.1 - 8.2 4.5 18.7 8.2 4.5 18.7 1.0 1 0 0 1 1 1 0 Nop14-like family ALMT PF11744.8 ETO27130.1 - 8.6 5.1 9.4 9.5 4.9 9.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NACHT PF05729.12 ETO27131.1 - 3.5e-09 36.8 0.0 1.4e-08 34.9 0.0 2.0 2 0 0 2 2 2 1 NACHT domain RelA_SpoT PF04607.17 ETO27131.1 - 0.00075 19.8 6.2 0.0043 17.3 0.2 4.3 3 0 0 3 3 3 1 Region found in RelA / SpoT proteins AAA_22 PF13401.6 ETO27131.1 - 0.021 15.1 0.1 0.17 12.2 0.1 2.6 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETO27131.1 - 0.038 13.9 0.7 0.47 10.3 0.0 2.9 2 1 0 2 2 2 0 RsgA GTPase AAA_16 PF13191.6 ETO27131.1 - 0.12 12.7 0.1 0.75 10.2 0.1 2.3 1 1 0 1 1 1 0 AAA ATPase domain Caprin-1_C PF12287.8 ETO27132.1 - 0.062 13.4 6.2 0.12 12.5 6.2 1.4 1 0 0 1 1 1 0 Cytoplasmic activation/proliferation-associated protein-1 C term MAT1 PF06391.13 ETO27132.1 - 0.93 9.3 8.6 2.3 8.0 8.6 1.6 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 TPR_12 PF13424.6 ETO27133.1 - 1.2e-40 137.7 6.0 4.3e-18 65.4 0.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27133.1 - 3.6e-31 106.1 6.7 1.8e-09 37.1 0.0 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27133.1 - 7.8e-27 92.0 33.6 2.8e-08 33.2 1.1 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27133.1 - 9e-26 87.9 26.6 3.2e-06 26.9 0.1 5.7 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27133.1 - 1.5e-25 87.3 4.8 3.4e-06 26.7 0.0 5.6 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27133.1 - 4.7e-23 79.4 25.8 1.7e-05 24.6 0.3 6.0 6 0 0 6 6 5 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27133.1 - 1.5e-11 43.8 19.0 0.0021 17.7 0.6 6.6 5 1 1 6 6 6 2 TPR repeat TPR_16 PF13432.6 ETO27133.1 - 3.3e-11 43.7 1.1 0.0012 19.4 0.0 5.2 4 1 1 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27133.1 - 1.9e-10 40.4 11.6 0.16 12.4 0.1 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO27133.1 - 1.8e-08 34.5 0.3 0.089 13.7 0.0 5.2 6 0 0 6 6 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO27133.1 - 1.9e-08 34.4 4.3 3.6 8.4 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat PPR PF01535.20 ETO27133.1 - 6.2e-06 26.1 1.7 0.46 10.8 0.0 5.2 4 0 0 4 4 4 1 PPR repeat TPR_19 PF14559.6 ETO27133.1 - 5.2e-05 23.7 2.3 0.052 14.1 0.3 3.5 2 1 3 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO27133.1 - 5.9e-05 22.6 0.0 0.00012 21.6 0.0 1.5 1 0 0 1 1 1 1 MalT-like TPR region TPR_3 PF07720.12 ETO27133.1 - 0.00042 20.2 11.5 0.071 13.1 0.0 4.7 5 0 0 5 5 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO27133.1 - 0.0053 16.8 11.6 4.3 7.5 0.1 5.4 4 1 1 5 5 5 1 MIT (microtubule interacting and transport) domain PDR_assoc PF08370.11 ETO27133.1 - 0.013 15.3 0.8 0.043 13.5 0.8 1.9 1 0 0 1 1 1 0 Plant PDR ABC transporter associated DUF1772 PF08592.11 ETO27133.1 - 0.033 14.5 0.1 0.062 13.6 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1772) SHNi-TPR PF10516.9 ETO27133.1 - 0.045 13.2 0.0 1.5 8.3 0.0 2.7 2 0 0 2 2 2 0 SHNi-TPR DUF5113 PF17140.4 ETO27133.1 - 0.17 11.7 12.3 2.5 7.9 0.3 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETO27133.1 - 2.3 9.0 4.9 15 6.5 0.2 3.9 3 0 0 3 3 3 0 Sel1 repeat RPN7 PF10602.9 ETO27133.1 - 4 7.1 8.8 12 5.6 0.0 3.9 3 1 1 5 5 4 0 26S proteasome subunit RPN7 PPR_2 PF13041.6 ETO27133.1 - 6.3 7.1 13.8 4.5 7.5 0.0 5.2 6 0 0 6 6 6 0 PPR repeat family PrsW-protease PF13367.6 ETO27134.1 - 9.2e-10 38.3 4.9 1e-09 38.1 4.9 1.2 1 0 0 1 1 1 1 PrsW family intramembrane metalloprotease DUF1146 PF06612.11 ETO27134.1 - 0.029 14.4 1.0 0.082 13.0 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1146) Methyltransf_10 PF05971.12 ETO27136.1 - 6.1e-45 153.8 9.6 2.3e-41 142.1 9.6 3.0 1 1 0 1 1 1 1 RNA methyltransferase MTS PF05175.14 ETO27136.1 - 0.00012 21.7 0.3 0.00046 19.8 0.3 1.8 1 1 0 1 1 1 1 Methyltransferase small domain Methyltransf_4 PF02390.17 ETO27136.1 - 0.02 14.3 0.3 0.02 14.3 0.3 1.8 2 0 0 2 2 2 0 Putative methyltransferase Cyclin_C PF02984.19 ETO27137.1 - 4.3e-11 42.9 0.2 5.6e-11 42.6 0.2 1.1 1 0 0 1 1 1 1 Cyclin, C-terminal domain Tropomodulin PF03250.14 ETO27138.1 - 0.25 11.4 9.3 0.28 11.2 8.5 1.4 1 1 0 1 1 1 0 Tropomodulin DUF5383 PF17355.2 ETO27138.1 - 1.2 9.5 13.7 2.5 8.5 13.7 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5383) WDCP PF15390.6 ETO27138.1 - 7.4 4.8 11.1 8.6 4.6 11.1 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Macoilin PF09726.9 ETO27139.1 - 5 5.6 14.0 6.9 5.1 14.0 1.2 1 0 0 1 1 1 0 Macoilin family 2-oxoacid_dh PF00198.23 ETO27140.1 - 6.4e-73 245.0 0.1 6.4e-73 245.0 0.1 1.5 2 0 0 2 2 2 1 2-oxoacid dehydrogenases acyltransferase (catalytic domain) Carb_kinase PF01256.17 ETO27140.1 - 0.078 12.4 0.1 0.15 11.5 0.1 1.4 1 0 0 1 1 1 0 Carbohydrate kinase FTA2 PF13095.6 ETO27141.1 - 0.0046 16.6 0.1 0.0054 16.4 0.1 1.1 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Pkinase PF00069.25 ETO27141.1 - 0.0048 16.3 0.1 0.0062 15.9 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Calsarcin PF05556.11 ETO27142.1 - 0.047 13.2 0.2 0.076 12.5 0.2 1.2 1 0 0 1 1 1 0 Calcineurin-binding protein (Calsarcin) Agouti PF05039.12 ETO27142.1 - 0.56 11.0 3.3 0.31 11.8 0.3 2.0 2 0 0 2 2 2 0 Agouti protein SPRY PF00622.28 ETO27144.1 - 0.0069 16.5 0.3 0.013 15.6 0.2 1.5 1 1 0 1 1 1 1 SPRY domain zf-C2HC5 PF06221.13 ETO27144.1 - 0.23 11.5 0.3 0.23 11.5 0.3 1.7 2 0 0 2 2 2 0 Putative zinc finger motif, C2HC5-type TrmO PF01980.16 ETO27146.1 - 5.7e-22 78.2 0.2 1.1e-21 77.3 0.2 1.5 1 0 0 1 1 1 1 tRNA-methyltransferase O LRR_4 PF12799.7 ETO27147.1 - 2.8e-15 56.2 18.9 1.6e-07 31.5 3.6 4.4 3 1 0 4 4 4 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO27147.1 - 5.8e-12 45.2 23.3 5.6e-06 26.0 1.5 4.4 2 2 2 4 4 4 3 Leucine rich repeat LRR_9 PF14580.6 ETO27147.1 - 6.5e-08 32.3 6.6 0.00013 21.5 2.4 3.1 1 1 2 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 ETO27147.1 - 0.00017 21.4 17.0 1.4 9.2 0.1 6.1 6 0 0 6 6 6 3 Leucine Rich repeat LRR_1 PF00560.33 ETO27147.1 - 0.00051 20.2 17.4 4.2 8.3 0.1 6.0 5 0 0 5 5 5 3 Leucine Rich Repeat DUF5427 PF10310.9 ETO27147.1 - 0.0082 15.1 16.2 0.012 14.7 16.2 1.3 1 0 0 1 1 1 1 Family of unknown function (DUF5427) DNA_pol_lambd_f PF10391.9 ETO27147.1 - 0.14 12.0 0.0 0.67 9.8 0.0 2.1 2 0 0 2 2 2 0 Fingers domain of DNA polymerase lambda SLC12 PF03522.15 ETO27147.1 - 0.59 9.1 22.0 0.95 8.4 22.0 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Apt1 PF10351.9 ETO27147.1 - 1.2 7.9 24.7 0.42 9.4 20.8 2.0 2 1 0 2 2 2 0 Golgi-body localisation protein domain DUF2981 PF11200.8 ETO27147.1 - 2.2 7.9 11.2 3.4 7.3 11.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Merozoite_SPAM PF07133.11 ETO27148.1 - 0.017 15.1 31.6 0.023 14.7 31.6 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Cwf_Cwc_15 PF04889.12 ETO27148.1 - 0.025 14.3 21.8 0.031 14.0 21.8 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Myc_N PF01056.18 ETO27148.1 - 0.031 14.2 14.7 0.037 13.9 14.7 1.2 1 0 0 1 1 1 0 Myc amino-terminal region YL1 PF05764.13 ETO27148.1 - 0.095 12.8 22.5 0.11 12.6 22.5 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 ETO27148.1 - 0.1 10.8 21.6 0.12 10.5 21.6 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO27148.1 - 0.26 9.6 18.3 0.3 9.3 18.3 1.0 1 0 0 1 1 1 0 CDC45-like protein SET PF00856.28 ETO27148.1 - 0.27 11.6 6.7 0.36 11.2 6.7 1.1 1 0 0 1 1 1 0 SET domain SDA1 PF05285.12 ETO27148.1 - 0.31 10.4 22.4 0.37 10.2 22.4 1.1 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 ETO27148.1 - 0.32 10.8 17.1 0.5 10.2 17.1 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region DNA_pol_phi PF04931.13 ETO27148.1 - 0.82 7.7 21.4 0.89 7.6 21.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2393 PF09624.10 ETO27148.1 - 3.3 7.7 6.6 4.1 7.4 6.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2393) Sin_N PF04801.13 ETO27148.1 - 4.2 6.5 16.1 5 6.2 16.1 1.0 1 0 0 1 1 1 0 Sin-like protein conserved region Dsh_C PF12316.8 ETO27148.1 - 4.4 7.6 9.0 4.9 7.5 9.0 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Hydin_ADK PF17213.3 ETO27148.1 - 6.1 7.1 10.3 7.2 6.8 10.3 1.1 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain CAC1F_C PF16885.5 ETO27148.1 - 6.6 6.3 14.1 7.6 6.1 14.1 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Raftlin PF15250.6 ETO27148.1 - 8.6 5.0 14.6 9.1 4.9 14.6 1.0 1 0 0 1 1 1 0 Raftlin RRN3 PF05327.11 ETO27148.1 - 9.7 4.6 14.1 12 4.3 14.1 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TLP-20 PF06088.11 ETO27150.1 - 0.0047 16.8 0.9 0.0072 16.2 0.9 1.2 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) DUF2457 PF10446.9 ETO27150.1 - 6.9 5.7 14.0 8.2 5.4 14.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) BAAT_C PF08840.11 ETO27151.1 - 0.016 15.1 0.1 0.11 12.4 0.1 2.1 1 1 1 2 2 2 0 BAAT / Acyl-CoA thioester hydrolase C terminal Peptidase_S9 PF00326.21 ETO27151.1 - 0.029 13.8 0.0 0.074 12.5 0.0 1.7 2 0 0 2 2 2 0 Prolyl oligopeptidase family Phage_T4_Ndd PF06591.11 ETO27151.1 - 0.055 13.3 0.0 0.088 12.6 0.0 1.3 1 0 0 1 1 1 0 T4-like phage nuclear disruption protein (Ndd) Hydrolase_4 PF12146.8 ETO27151.1 - 0.093 12.0 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Serine aminopeptidase, S33 ANAPC4_WD40 PF12894.7 ETO27152.1 - 0.011 16.0 0.3 28 5.1 0.0 3.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain MAJIN PF15077.6 ETO27152.1 - 0.59 9.9 9.5 0.099 12.4 5.0 2.0 2 0 0 2 2 2 0 Membrane-anchored junction protein UPF0242 PF06785.11 ETO27152.1 - 1.5 8.9 10.7 11 6.0 4.7 2.5 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Presenilin PF01080.17 ETO27152.1 - 8.9 5.0 7.1 18 4.0 7.1 1.5 1 0 0 1 1 1 0 Presenilin DEC-1_N PF04625.13 ETO27153.1 - 5.7 5.8 12.3 8.5 5.3 12.3 1.2 1 0 0 1 1 1 0 DEC-1 protein, N-terminal region DUF2975 PF11188.8 ETO27154.1 - 0.091 12.7 2.6 0.14 12.0 2.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2975) DNA_pol_phi PF04931.13 ETO27154.1 - 9.3 4.2 12.0 0.72 7.9 7.5 1.4 1 1 1 2 2 2 0 DNA polymerase phi zf-TRAF PF02176.18 ETO27155.1 - 1.7e-09 38.2 13.0 3e-07 31.0 3.9 2.4 1 1 1 2 2 2 2 TRAF-type zinc finger Kelch_1 PF01344.25 ETO27155.1 - 0.16 11.6 0.0 4.3 7.0 0.0 2.5 2 0 0 2 2 2 0 Kelch motif NACHT PF05729.12 ETO27156.1 - 1e-10 41.8 0.0 2.3e-10 40.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO27156.1 - 0.00014 22.2 1.2 0.00046 20.5 0.3 2.4 2 1 0 2 2 2 1 AAA domain RelA_SpoT PF04607.17 ETO27156.1 - 0.00082 19.6 1.4 0.00082 19.6 1.4 2.4 3 0 0 3 3 3 1 Region found in RelA / SpoT proteins ABC2_membrane_3 PF12698.7 ETO27156.1 - 0.0076 15.4 4.6 0.014 14.6 4.6 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein Orf78 PF06024.12 ETO27156.1 - 0.0088 16.3 3.4 0.022 15.0 3.4 1.7 1 0 0 1 1 1 1 Orf78 (ac78) AAA_16 PF13191.6 ETO27156.1 - 0.027 14.9 0.0 0.11 12.9 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 ETO27156.1 - 0.083 13.4 1.6 0.3 11.7 0.0 2.5 3 0 0 3 3 3 0 AAA domain TMEM154 PF15102.6 ETO27156.1 - 0.22 11.4 3.3 0.45 10.4 3.3 1.4 1 0 0 1 1 1 0 TMEM154 protein family Pox_EPC_I2-L1 PF12575.8 ETO27156.1 - 0.66 10.2 3.5 0.68 10.2 1.4 2.0 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 Synaptobrevin PF00957.21 ETO27156.1 - 1.2 8.9 10.5 0.3 10.9 5.7 2.4 2 0 0 2 2 2 0 Synaptobrevin WD40 PF00400.32 ETO27157.1 - 9.1e-141 453.6 50.8 2.2e-11 44.1 0.2 14.3 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27157.1 - 4.9e-48 161.4 12.4 7.1e-05 23.0 0.2 12.4 1 1 12 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27157.1 - 4.8e-26 91.5 8.8 0.047 12.7 0.0 12.1 2 1 9 13 13 13 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27157.1 - 1.3e-16 60.8 7.2 0.002 17.5 0.1 6.7 3 2 2 6 6 6 6 WD40-like domain Nup160 PF11715.8 ETO27157.1 - 2e-12 46.6 26.2 0.16 10.6 0.2 10.1 2 2 8 10 10 10 6 Nucleoporin Nup120/160 PD40 PF07676.12 ETO27157.1 - 1.4e-09 37.6 1.7 3.3 7.8 0.0 8.0 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO27157.1 - 6.3e-09 35.3 1.6 1.6e-08 34.0 1.6 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Cytochrom_D1 PF02239.16 ETO27157.1 - 9e-09 34.3 1.7 3.6 6.0 0.0 6.4 1 1 7 9 9 9 3 Cytochrome D1 heme domain Str_synth PF03088.16 ETO27157.1 - 2.6e-08 33.9 13.0 18 5.5 0.1 10.7 5 4 7 12 12 12 0 Strictosidine synthase SGL PF08450.12 ETO27157.1 - 7.3e-07 29.0 5.5 0.013 15.0 0.7 4.8 1 1 3 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Pentapeptide_4 PF13599.6 ETO27157.1 - 2e-05 24.7 0.1 6.4e-05 23.0 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO27157.1 - 8.3e-05 22.7 11.6 17 5.5 0.0 7.9 4 2 4 9 9 9 0 Family of unknown function (DUF5570) Ret2_MD PF18528.1 ETO27157.1 - 0.00016 22.0 0.0 0.65 10.4 0.0 4.8 4 1 1 5 5 4 1 RNA editing 3' terminal uridylyl transferase 2 middle domain nos_propeller PF18764.1 ETO27157.1 - 0.00019 21.3 0.5 50 3.9 0.0 6.8 9 0 0 9 9 9 0 Nitrous oxide reductase propeller repeat Nbas_N PF15492.6 ETO27157.1 - 0.00021 20.7 7.4 2.7 7.2 0.0 6.5 3 2 4 8 8 8 1 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO27157.1 - 0.00026 20.6 10.9 19 5.1 0.0 8.5 10 0 0 10 10 10 0 Proteasome subunit A N-terminal signature Pentapeptide_3 PF13576.6 ETO27157.1 - 0.0011 19.1 0.3 0.0063 16.6 0.3 2.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Peptidase_C9 PF01707.16 ETO27157.1 - 0.0023 17.6 1.0 1.6 8.2 0.0 3.5 3 1 1 4 4 4 1 Peptidase family C9 MmlI PF09448.10 ETO27157.1 - 0.12 12.8 0.1 0.94 10.0 0.1 2.2 2 0 0 2 2 2 0 Methylmuconolactone methyl-isomerase WD40 PF00400.32 ETO27158.1 - 1.4e-22 79.6 20.7 1.8e-06 28.5 0.7 6.2 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27158.1 - 5e-06 26.7 0.6 0.44 10.9 0.0 4.6 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27158.1 - 0.00054 18.7 1.3 0.62 8.6 0.1 3.7 1 1 2 3 3 3 3 Nucleoporin Nup120/160 GSDH PF07995.11 ETO27159.1 - 4.3e-06 26.3 0.2 1.1e-05 24.9 0.1 1.6 2 0 0 2 2 2 1 Glucose / Sorbosone dehydrogenase PS_Dcarbxylase PF02666.15 ETO27160.1 - 4.8e-51 173.2 0.0 7e-51 172.6 0.0 1.2 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase EF-hand_6 PF13405.6 ETO27161.1 - 2.3e-09 36.4 0.1 0.0031 17.3 0.0 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO27161.1 - 0.00037 19.8 0.6 0.035 13.7 0.0 2.7 2 1 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO27161.1 - 0.0032 17.9 0.4 0.0087 16.5 0.4 1.7 1 0 0 1 1 1 1 EF-hand domain pair Caleosin PF05042.13 ETO27161.1 - 0.14 12.1 0.3 16 5.4 0.1 2.2 1 1 1 2 2 2 0 Caleosin related protein RabGAP-TBC PF00566.18 ETO27164.1 - 2.3e-05 24.2 0.4 2.3e-05 24.2 0.4 4.6 4 1 0 4 4 4 3 Rab-GTPase-TBC domain MFS_1 PF07690.16 ETO27165.1 - 0.052 12.5 1.1 0.066 12.1 1.1 1.1 1 0 0 1 1 1 0 Major Facilitator Superfamily ABC2_membrane PF01061.24 ETO27167.1 - 4.8e-44 150.3 22.3 4.8e-44 150.3 22.3 1.5 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO27167.1 - 1.2e-07 31.2 28.2 3.9e-07 29.5 28.2 2.0 1 1 0 1 1 1 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ETO27167.1 - 0.00032 20.1 8.8 0.00032 20.1 8.8 2.2 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC_tran PF00005.27 ETO27168.1 - 1.7e-10 41.5 3.5 3.5e-10 40.5 0.2 2.4 3 0 0 3 3 3 1 ABC transporter GSH-S_ATP PF02955.16 ETO27169.1 - 0.071 12.5 0.0 15 4.9 0.0 2.5 2 0 0 2 2 2 0 Prokaryotic glutathione synthetase, ATP-grasp domain CENP-C_C PF11699.8 ETO27170.1 - 3.9e-07 30.2 0.1 9.4e-07 29.0 0.1 1.6 1 1 0 1 1 1 1 Mif2/CENP-C like Glyco_hydro_31 PF01055.26 ETO27171.1 - 1.6e-29 103.4 6.2 1.6e-29 103.4 6.2 2.4 2 1 0 2 2 2 1 Glycosyl hydrolases family 31 DUF5110 PF17137.4 ETO27171.1 - 5.6e-07 29.7 3.7 1.2e-06 28.7 3.7 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF5110) Lipocalin_4 PF13648.6 ETO27171.1 - 0.049 14.6 1.6 0.19 12.7 1.6 2.0 1 0 0 1 1 1 0 Lipocalin-like domain Actin PF00022.19 ETO27174.1 - 3.3e-76 256.5 0.0 3.7e-75 253.0 0.0 1.9 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO27174.1 - 0.019 13.8 0.0 0.075 11.8 0.0 1.7 1 1 0 1 1 1 0 MreB/Mbl protein RicinB_lectin_2 PF14200.6 ETO27176.1 - 1.1e-19 70.9 0.0 6e-11 42.9 0.0 2.1 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ETO27176.1 - 3e-06 27.5 0.3 4.4e-06 27.0 0.3 1.2 1 0 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Ras PF00071.22 ETO27178.1 - 4.6e-61 205.2 1.4 5.3e-61 205.0 1.4 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO27178.1 - 9.4e-36 122.7 0.8 1.2e-35 122.3 0.2 1.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO27178.1 - 6.3e-18 64.8 0.2 7.2e-18 64.6 0.2 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO27178.1 - 9.2e-06 25.3 0.7 4.5e-05 23.1 0.7 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO27178.1 - 4.5e-05 22.9 0.2 5.5e-05 22.6 0.2 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ETO27178.1 - 5.1e-05 22.8 0.1 6.6e-05 22.4 0.1 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO27178.1 - 6.8e-05 22.9 0.0 0.00012 22.1 0.0 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO27178.1 - 0.0012 18.8 0.2 0.48 10.3 0.2 2.7 1 1 2 3 3 3 2 RsgA GTPase AAA_16 PF13191.6 ETO27178.1 - 0.0018 18.7 0.0 0.0028 18.1 0.0 1.4 1 1 0 1 1 1 1 AAA ATPase domain MMR_HSR1_Xtn PF16897.5 ETO27178.1 - 0.0067 16.4 0.1 0.0092 16.0 0.1 1.3 1 0 0 1 1 1 1 C-terminal region of MMR_HSR1 domain TniB PF05621.11 ETO27178.1 - 0.085 12.3 0.0 0.18 11.2 0.0 1.6 1 0 0 1 1 1 0 Bacterial TniB protein FeoB_N PF02421.18 ETO27178.1 - 0.12 11.9 0.0 2 7.9 0.0 2.1 2 0 0 2 2 2 0 Ferrous iron transport protein B NACHT PF05729.12 ETO27178.1 - 0.15 11.9 0.0 0.28 11.1 0.0 1.5 1 0 0 1 1 1 0 NACHT domain DUF148 PF02520.17 ETO27179.1 - 0.012 15.7 3.8 0.012 15.7 3.8 3.1 4 1 0 4 4 4 0 Domain of unknown function DUF148 SAM_KSR1 PF13543.6 ETO27179.1 - 0.075 13.2 5.5 0.22 11.7 0.0 3.2 2 1 1 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 zf-3CxxC PF13695.6 ETO27179.1 - 0.54 10.8 3.9 0.89 10.1 2.6 2.1 1 1 1 2 2 2 0 Zinc-binding domain WD40 PF00400.32 ETO27180.1 - 6.5e-09 36.3 5.2 0.031 15.1 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat Myc_N PF01056.18 ETO27180.1 - 0.0039 17.1 10.1 1.7 8.5 0.0 2.3 2 0 0 2 2 2 2 Myc amino-terminal region Lin-8 PF03353.15 ETO27180.1 - 0.29 10.6 9.6 0.026 14.1 4.5 1.7 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist CDC45 PF02724.14 ETO27180.1 - 0.52 8.5 10.6 0.74 8.0 6.3 2.0 2 0 0 2 2 2 0 CDC45-like protein PQQ_3 PF13570.6 ETO27180.1 - 0.56 10.8 1.9 2.9 8.5 0.1 3.0 4 0 0 4 4 4 0 PQQ-like domain SDA1 PF05285.12 ETO27180.1 - 1 8.7 19.5 0.079 12.4 10.1 2.1 2 0 0 2 2 2 0 SDA1 Zip PF02535.22 ETO27180.1 - 6.2 5.9 5.6 7.5 5.7 2.5 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter DUF4820 PF16091.5 ETO27180.1 - 6.7 6.0 8.7 11 5.2 6.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) DUF5520 PF17658.1 ETO27180.1 - 7.7 5.5 9.3 11 5.0 8.4 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5520) Presenilin PF01080.17 ETO27180.1 - 8.4 5.0 5.9 1.2 7.8 1.7 1.7 2 0 0 2 2 2 0 Presenilin DUF2681 PF10883.8 ETO27181.1 - 1.3 9.5 5.2 3.3 8.2 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF2681) DUF2070 PF09843.9 ETO27181.1 - 2.7 6.2 7.8 3.8 5.7 7.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) Phosphodiest PF01663.22 ETO27182.1 - 2.6e-07 30.6 0.4 4.3e-05 23.3 0.1 2.1 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase PF00884.23 ETO27182.1 - 0.0043 16.5 0.0 0.24 10.8 0.0 2.2 1 1 1 2 2 2 2 Sulfatase Cellulose_synt PF03552.14 ETO27183.1 - 0.12 10.9 2.5 0.072 11.6 0.1 1.7 2 0 0 2 2 2 0 Cellulose synthase POX PF07526.11 ETO27183.1 - 1.7 9.2 15.0 2.2 8.9 3.0 2.9 2 1 1 3 3 3 0 Associated with HOX Kelch_3 PF13415.6 ETO27184.1 - 0.033 14.5 0.0 0.41 11.0 0.0 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO27184.1 - 0.037 14.3 0.3 3.7 8.0 0.0 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETO27184.1 - 0.038 14.0 0.2 29 4.8 0.0 3.6 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO27184.1 - 0.25 11.4 0.6 2.1 8.4 0.1 3.0 2 1 0 2 2 2 0 Galactose oxidase, central domain UQ_con PF00179.26 ETO27185.1 - 2.7e-19 69.2 0.2 4.1e-19 68.6 0.1 1.3 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme TRAPP PF04051.16 ETO27186.1 - 1.3e-30 106.0 0.0 2.1e-30 105.4 0.0 1.3 1 1 0 1 1 1 1 Transport protein particle (TRAPP) component SNARE PF05739.19 ETO27187.1 - 1e-06 28.6 0.1 1.8e-06 27.8 0.1 1.4 1 0 0 1 1 1 1 SNARE domain HIP1_clath_bdg PF16515.5 ETO27187.1 - 0.01 16.4 1.4 0.013 16.1 1.4 1.2 1 0 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 PTase_Orf2 PF11468.8 ETO27187.1 - 0.012 15.1 0.0 0.013 14.9 0.0 1.1 1 0 0 1 1 1 0 Aromatic prenyltransferase Orf2 HOOK PF05622.12 ETO27187.1 - 0.025 12.8 2.1 0.03 12.5 2.1 1.0 1 0 0 1 1 1 0 HOOK protein DUF1664 PF07889.12 ETO27187.1 - 0.07 13.2 1.0 0.1 12.6 1.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ApoLp-III PF07464.11 ETO27187.1 - 0.096 12.8 0.8 0.3 11.2 0.4 1.8 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) TolA_bind_tri PF16331.5 ETO27188.1 - 0.017 15.2 0.2 0.017 15.2 0.2 3.2 3 0 0 3 3 3 0 TolA binding protein trimerisation SSP160 PF06933.11 ETO27188.1 - 1.2 7.3 6.2 0.14 10.3 1.7 1.6 2 0 0 2 2 2 0 Special lobe-specific silk protein SSP160 DUF4698 PF15769.5 ETO27189.1 - 0.055 12.5 7.7 0.076 12.1 7.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) ATP11 PF06644.11 ETO27189.1 - 6.1 6.5 10.7 0.23 11.2 4.9 1.5 2 0 0 2 2 2 0 ATP11 protein IBR PF01485.21 ETO27190.1 - 8.1e-11 42.0 9.0 8.1e-11 42.0 9.0 2.8 3 0 0 3 3 3 2 IBR domain, a half RING-finger domain PRP21_like_P PF12230.8 ETO27190.1 - 0.16 11.8 0.3 0.28 11.0 0.3 1.3 1 0 0 1 1 1 0 Pre-mRNA splicing factor PRP21 like protein UQ_con PF00179.26 ETO27192.1 - 6.2e-17 61.6 0.6 9.5e-17 61.0 0.4 1.4 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Pesticin PF16754.5 ETO27193.1 - 2.6e-10 40.5 0.0 5.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Bacterial toxin homologue of phage lysozyme, C-term DUF2306 PF10067.9 ETO27195.1 - 0.0055 16.9 1.8 0.0055 16.9 1.8 1.9 3 0 0 3 3 3 1 Predicted membrane protein (DUF2306) DUF4220 PF13968.6 ETO27195.1 - 0.0075 15.7 1.2 0.0075 15.7 1.2 1.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4220) UPF0542 PF15086.6 ETO27195.1 - 0.039 13.9 3.8 6.6 6.7 0.0 3.1 3 0 0 3 3 3 0 Uncharacterised protein family UPF0542 PEN-2 PF10251.9 ETO27195.1 - 1.6 9.2 16.9 0.2 12.1 0.3 3.2 2 1 1 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase RR_TM4-6 PF06459.12 ETO27196.1 - 0.015 15.1 21.8 0.015 15.1 21.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Vfa1 PF08432.10 ETO27196.1 - 0.047 14.0 27.9 0.062 13.6 27.9 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3807 PF12720.7 ETO27196.1 - 0.26 11.6 23.3 0.35 11.1 23.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) SAPS PF04499.15 ETO27196.1 - 0.66 8.7 11.7 0.6 8.8 11.7 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Dsh_C PF12316.8 ETO27196.1 - 1.3 9.4 11.3 1.7 9.0 11.3 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal AAA_11 PF13086.6 ETO27196.1 - 1.3 8.8 15.4 1.5 8.6 15.4 1.1 1 0 0 1 1 1 0 AAA domain Hid1 PF12722.7 ETO27196.1 - 1.8 6.6 13.2 1.8 6.6 13.2 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO27196.1 - 3.1 6.4 19.5 3.5 6.3 19.5 1.1 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 ETO27196.1 - 3.9 6.4 9.8 4.2 6.3 9.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein DUF913 PF06025.12 ETO27196.1 - 7.3 5.5 12.8 8.3 5.3 12.8 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TPR_12 PF13424.6 ETO27197.1 - 8.1e-51 170.2 2.6 3e-16 59.5 0.5 5.2 4 1 2 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27197.1 - 1.3e-39 133.0 0.2 1.5e-09 37.4 0.0 7.8 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27197.1 - 2.5e-34 115.7 34.2 1.9e-08 33.8 1.5 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27197.1 - 3.5e-32 108.1 7.4 3.3e-07 29.9 0.0 8.1 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27197.1 - 1.4e-30 102.9 32.4 1.3e-07 31.2 1.4 8.3 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27197.1 - 1.1e-29 100.1 20.4 3e-06 26.9 0.4 8.1 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27197.1 - 2.8e-11 43.0 9.9 0.029 14.8 0.2 6.0 5 1 0 5 5 4 3 Tetratricopeptide repeat MIT PF04212.18 ETO27197.1 - 3.6e-09 36.5 14.1 0.00099 19.1 0.2 6.7 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO27197.1 - 3e-08 33.8 6.1 3.3 8.6 0.1 7.0 8 1 0 8 8 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO27197.1 - 2.4e-07 30.5 0.0 0.0002 20.9 0.0 2.3 1 1 2 3 3 3 2 MalT-like TPR region SNAP PF14938.6 ETO27197.1 - 2.6e-07 30.4 4.0 8.2e-05 22.2 0.1 3.4 2 1 1 3 3 3 1 Soluble NSF attachment protein, SNAP TPR_16 PF13432.6 ETO27197.1 - 5.8e-07 30.1 0.0 0.23 12.1 0.0 5.1 5 2 2 7 7 6 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO27197.1 - 3.5e-06 27.4 0.0 37 5.5 0.0 6.1 7 0 0 7 7 5 0 Tetratricopeptide repeat DUF627 PF04781.12 ETO27197.1 - 1.5e-05 25.0 3.4 1.6 8.8 0.0 5.2 4 1 1 5 5 5 1 Protein of unknown function (DUF627) DUF5113 PF17140.4 ETO27197.1 - 2.7e-05 24.0 17.2 0.81 9.5 1.9 5.5 4 2 2 6 6 5 3 Domain of unknown function (DUF5113) TPR_21 PF09976.9 ETO27197.1 - 0.00035 20.3 0.1 0.072 12.8 0.1 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat-like domain TPR_19 PF14559.6 ETO27197.1 - 0.0004 20.8 2.0 0.94 10.0 0.0 4.7 4 2 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27197.1 - 0.00064 19.4 37.8 0.76 9.5 1.2 9.2 8 3 1 10 10 10 2 TPR repeat ANAPC3 PF12895.7 ETO27197.1 - 0.0009 19.4 12.2 0.047 13.9 1.5 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex, cyclosome, subunit 3 Sel1 PF08238.12 ETO27197.1 - 0.0011 19.5 6.8 4 8.3 0.1 5.6 5 1 0 5 5 5 1 Sel1 repeat DUF4810 PF16068.5 ETO27197.1 - 0.0018 18.8 2.9 3.1 8.4 0.2 4.2 3 2 0 3 3 3 1 Domain of unknown function (DUF4810) TPR_3 PF07720.12 ETO27197.1 - 0.011 15.7 28.7 0.11 12.5 0.2 8.0 9 0 0 9 9 9 0 Tetratricopeptide repeat PPR PF01535.20 ETO27197.1 - 0.02 15.1 5.4 11 6.6 0.3 5.7 6 0 0 6 6 5 0 PPR repeat TetR_C_19 PF17924.1 ETO27197.1 - 0.024 15.2 0.4 1.5 9.4 0.1 3.6 3 0 0 3 3 3 0 Tetracyclin repressor-like, C-terminal domain TPR_5 PF12688.7 ETO27197.1 - 0.06 13.6 0.0 12 6.1 0.0 3.0 2 1 1 3 3 2 0 Tetratrico peptide repeat SHNi-TPR PF10516.9 ETO27197.1 - 0.21 11.1 7.1 32 4.1 0.0 4.8 6 0 0 6 6 5 0 SHNi-TPR HTH_Bact PF18768.1 ETO27197.1 - 0.39 10.3 10.1 23 4.7 0.1 5.9 6 0 0 6 6 6 0 Helix-turn-helix bacterial domain SPO22 PF08631.10 ETO27197.1 - 0.54 9.7 6.5 3.2 7.2 0.2 3.8 2 1 2 4 4 4 0 Meiosis protein SPO22/ZIP4 like Mob_Pre PF01076.19 ETO27197.1 - 1.3 8.8 6.9 25 4.6 0.2 3.9 3 1 2 5 5 5 0 Plasmid recombination enzyme Fis1_TPR_C PF14853.6 ETO27197.1 - 1.9 8.6 15.8 1.7 8.8 0.2 5.3 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat WD40 PF00400.32 ETO27198.1 - 2.5e-23 81.9 15.4 2.1e-07 31.5 2.6 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO27198.1 - 1.1e-07 30.9 1.6 0.0038 15.9 0.4 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO27198.1 - 1.3e-05 25.4 0.2 0.085 13.2 0.1 3.0 2 2 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO27198.1 - 0.002 17.5 1.6 0.016 14.5 0.6 2.3 1 1 1 2 2 2 1 WD40-like domain HARP PF07443.13 ETO27198.1 - 0.031 13.9 0.1 3.4 7.4 0.0 3.0 3 0 0 3 3 3 0 HepA-related protein (HARP) SH3_13 PF18335.1 ETO27198.1 - 0.21 11.4 1.0 2.1 8.2 0.3 2.4 1 1 1 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain DUF4064 PF13273.6 ETO27199.1 - 0.0019 18.5 2.3 0.0055 17.0 0.4 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF4064) DUF2721 PF11026.8 ETO27199.1 - 0.035 14.0 5.2 2 8.3 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) AveC_like PF17198.4 ETO27199.1 - 0.038 13.4 0.5 0.038 13.4 0.5 1.8 2 0 0 2 2 2 0 Spirocyclase AveC-like Trypsin_2 PF13365.6 ETO27200.1 - 7.3e-19 69.1 0.0 8.7e-13 49.4 0.0 3.0 3 0 0 3 3 3 2 Trypsin-like peptidase domain Inositol_P PF00459.25 ETO27201.1 - 1.1e-14 54.6 0.0 2.4e-12 47.0 0.0 3.0 3 0 0 3 3 3 2 Inositol monophosphatase family NAD_binding_10 PF13460.6 ETO27201.1 - 0.0017 18.3 0.1 0.0056 16.6 0.0 1.9 2 0 0 2 2 2 1 NAD(P)H-binding Agenet PF05641.12 ETO27201.1 - 0.011 16.2 2.1 1.1 9.8 0.1 2.8 2 0 0 2 2 2 0 Agenet domain NACHT PF05729.12 ETO27202.1 - 5.2e-07 29.7 0.1 1.1e-06 28.7 0.1 1.5 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO27202.1 - 1.1e-05 25.8 0.0 3.4e-05 24.3 0.0 1.8 2 0 0 2 2 2 1 AAA ATPase domain NB-ARC PF00931.22 ETO27202.1 - 3.3e-05 23.2 1.7 7.4e-05 22.0 1.7 1.6 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO27202.1 - 0.0002 21.7 0.5 0.00066 20.0 0.0 2.0 2 0 0 2 2 2 1 AAA domain RsgA_GTPase PF03193.16 ETO27202.1 - 0.0092 15.9 0.0 0.027 14.4 0.0 1.8 1 0 0 1 1 1 1 RsgA GTPase Cbl_N2 PF02761.14 ETO27202.1 - 0.033 14.9 0.1 0.2 12.4 0.1 2.4 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, EF hand-like domain DAP3 PF10236.9 ETO27202.1 - 0.035 13.3 0.0 0.077 12.1 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 CHAT PF12770.7 ETO27202.1 - 0.16 11.4 0.0 0.3 10.4 0.0 1.5 1 0 0 1 1 1 0 CHAT domain Lyase_1 PF00206.20 ETO27203.1 - 1.2e-79 267.9 0.0 6.1e-55 186.8 0.0 2.0 2 0 0 2 2 2 2 Lyase FumaraseC_C PF10415.9 ETO27204.1 - 1.6e-27 95.6 0.1 2.4e-27 95.1 0.1 1.3 1 0 0 1 1 1 1 Fumarase C C-terminus Lyase_1 PF00206.20 ETO27204.1 - 2.3e-06 27.2 0.6 2.3e-06 27.2 0.6 1.6 2 1 0 2 2 2 1 Lyase G-alpha PF00503.20 ETO27204.1 - 0.023 13.8 0.0 0.024 13.8 0.0 1.1 1 0 0 1 1 1 0 G-protein alpha subunit eIF-3c_N PF05470.12 ETO27205.1 - 0.00072 18.0 1.8 0.00091 17.7 1.8 1.0 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus C-C_Bond_Lyase PF15617.6 ETO27205.1 - 0.0069 15.6 0.1 0.0083 15.3 0.1 1.1 1 0 0 1 1 1 1 C-C_Bond_Lyase of the TIM-Barrel fold SHS2_Rpb7-N PF03876.17 ETO27206.1 - 3.7e-11 43.2 0.0 5.9e-11 42.6 0.0 1.3 1 0 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ETO27206.1 - 4.7e-08 33.2 0.0 1.1e-07 32.0 0.0 1.6 1 1 0 1 1 1 1 S1 RNA binding domain RNA_pol_Rbc25 PF08292.12 ETO27206.1 - 0.0027 18.0 0.0 0.0046 17.2 0.0 1.4 1 0 0 1 1 1 1 RNA polymerase III subunit Rpc25 Pyrophosphatase PF00719.19 ETO27208.1 - 2.8e-28 98.7 0.0 3.2e-28 98.6 0.0 1.1 1 0 0 1 1 1 1 Inorganic pyrophosphatase Spc7 PF08317.11 ETO27209.1 - 0.002 17.1 12.7 0.002 17.1 12.7 4.1 4 0 0 4 4 4 1 Spc7 kinetochore protein Auts2 PF15336.6 ETO27209.1 - 0.0021 18.2 4.9 0.0021 18.2 4.9 3.8 5 0 0 5 5 5 1 Autism susceptibility gene 2 protein Connexin PF00029.19 ETO27209.1 - 0.0069 16.2 2.0 0.0069 16.2 2.0 3.8 3 1 0 3 3 3 1 Connexin PUMA PF15826.5 ETO27209.1 - 0.013 15.7 0.6 0.013 15.7 0.6 1.9 2 0 0 2 2 2 0 Bcl-2-binding component 3, p53 upregulated modulator of apoptosis Eapp_C PF10238.9 ETO27209.1 - 1.3 9.1 22.1 0.29 11.2 2.2 3.9 3 0 0 3 3 3 0 E2F-associated phosphoprotein FCP1_C PF09309.10 ETO27210.1 - 0.23 11.3 11.0 0.039 13.8 5.4 2.0 2 0 0 2 2 2 0 FCP1, C-terminal COMPASS-Shg1 PF05205.12 ETO27210.1 - 1.5 9.6 9.7 0.45 11.3 3.6 2.1 2 0 0 2 2 2 0 COMPASS (Complex proteins associated with Set1p) component shg1 YojJ PF10372.9 ETO27211.1 - 0.016 15.3 0.1 0.034 14.2 0.1 1.5 1 0 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus Ion_trans PF00520.31 ETO27212.1 - 2.4e-13 49.9 22.9 5.7e-13 48.7 22.9 1.6 1 0 0 1 1 1 1 Ion transport protein DNA_RNApol_7kD PF03604.13 ETO27212.1 - 0.19 11.4 1.3 0.64 9.8 0.3 2.2 2 0 0 2 2 2 0 DNA directed RNA polymerase, 7 kDa subunit Zn_ribbon_recom PF13408.6 ETO27212.1 - 0.25 11.9 3.5 0.7 10.5 3.5 1.7 1 0 0 1 1 1 0 Recombinase zinc beta ribbon domain FerI PF08151.12 ETO27213.1 - 0.31 11.2 0.1 0.31 11.2 0.1 2.0 2 0 0 2 2 2 0 FerI (NUC094) domain DUF1712 PF08217.11 ETO27214.1 - 3.2e-11 42.5 0.2 5.2e-11 41.8 0.0 1.5 1 1 0 1 1 1 1 Fungal domain of unknown function (DUF1712) Mucin PF01456.17 ETO27215.1 - 0.21 11.6 19.6 0.41 10.6 19.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Sin3a_C PF16879.5 ETO27217.1 - 0.00011 22.0 0.1 0.00011 22.0 0.1 3.5 3 1 1 4 4 4 2 C-terminal domain of Sin3a protein Trypan_PARP PF05887.11 ETO27217.1 - 0.026 14.5 24.4 0.061 13.3 24.4 1.6 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) BUD22 PF09073.10 ETO27217.1 - 0.068 12.5 20.3 0.14 11.5 20.3 1.5 1 0 0 1 1 1 0 BUD22 NTP_transf_2 PF01909.23 ETO27217.1 - 0.81 10.0 0.0 0.81 10.0 0.0 2.4 3 0 0 3 3 3 0 Nucleotidyltransferase domain ABC2_membrane_3 PF12698.7 ETO27217.1 - 2.9 6.9 6.1 1.1 8.2 2.9 1.8 2 0 0 2 2 2 0 ABC-2 family transporter protein CPL PF08144.11 ETO27218.1 - 5.1e-13 49.6 6.3 4.2e-07 30.4 0.0 4.6 4 2 0 4 4 4 2 CPL (NUC119) domain Tim54 PF11711.8 ETO27218.1 - 0.11 11.3 6.5 1.9 7.2 0.6 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SOG2 PF10428.9 ETO27219.1 - 2.2 7.4 22.4 2.6 7.1 22.4 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Utp14 PF04615.13 ETO27219.1 - 2.7 6.5 10.7 3.1 6.3 10.7 1.0 1 0 0 1 1 1 0 Utp14 protein SMG1 PF15785.5 ETO27220.1 - 0.15 10.4 3.7 0.18 10.2 3.7 1.1 1 0 0 1 1 1 0 Serine/threonine-protein kinase smg-1 Connexin PF00029.19 ETO27221.1 - 0.00084 19.2 15.8 0.018 14.8 1.5 2.5 2 1 1 3 3 3 2 Connexin Kei1 PF08552.11 ETO27221.1 - 0.0073 16.2 3.6 0.0073 16.2 3.6 2.7 1 1 1 2 2 2 1 Inositolphosphorylceramide synthase subunit Kei1 SpoIIIAH PF12685.7 ETO27221.1 - 0.0097 15.8 12.2 0.0097 15.8 12.2 1.7 2 0 0 2 2 2 1 SpoIIIAH-like protein Apt1 PF10351.9 ETO27221.1 - 0.0098 14.8 21.2 0.12 11.2 12.4 2.1 2 0 0 2 2 2 2 Golgi-body localisation protein domain CDC45 PF02724.14 ETO27221.1 - 0.011 14.1 20.2 0.017 13.5 20.2 1.2 1 0 0 1 1 1 0 CDC45-like protein Mem_trans PF03547.18 ETO27221.1 - 0.049 12.0 0.4 0.071 11.5 0.4 1.3 1 0 0 1 1 1 0 Membrane transport protein LAP1C PF05609.12 ETO27221.1 - 0.059 12.5 16.2 0.012 14.8 11.4 1.8 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) SID-1_RNA_chan PF13965.6 ETO27221.1 - 0.076 11.4 9.6 0.11 10.8 8.9 1.8 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 DUF21 PF01595.20 ETO27221.1 - 0.086 12.5 0.0 0.19 11.4 0.0 1.6 1 0 0 1 1 1 0 Cyclin M transmembrane N-terminal domain BT1 PF03092.16 ETO27221.1 - 0.093 10.9 1.8 0.13 10.5 1.8 1.2 1 0 0 1 1 1 0 BT1 family DUF4834 PF16118.5 ETO27221.1 - 0.18 12.8 22.7 32 5.6 18.5 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Nucleoside_tran PF01733.18 ETO27221.1 - 0.18 11.1 9.3 11 5.3 9.3 2.4 1 1 0 1 1 1 0 Nucleoside transporter Adipogenin PF15202.6 ETO27221.1 - 0.24 11.4 1.7 1.5 8.9 0.0 2.6 2 1 0 2 2 2 0 Adipogenin RNA_pol_Rpc4 PF05132.14 ETO27221.1 - 0.39 11.1 17.2 0.11 12.9 10.6 2.7 2 1 0 2 2 2 0 RNA polymerase III RPC4 Tim54 PF11711.8 ETO27221.1 - 0.45 9.2 17.8 0.32 9.8 14.6 2.0 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 OAD_gamma PF04277.13 ETO27221.1 - 2.4 8.8 0.0 2.4 8.8 0.0 3.3 2 1 1 3 3 2 0 Oxaloacetate decarboxylase, gamma chain PigN PF04987.14 ETO27221.1 - 2.7 6.8 11.3 10 4.8 11.0 2.2 1 1 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) Zip PF02535.22 ETO27221.1 - 5.7 6.1 15.7 1.1 8.4 11.3 1.8 1 1 0 2 2 2 0 ZIP Zinc transporter Serinc PF03348.15 ETO27221.1 - 6.2 5.6 17.3 1e+03 -1.7 17.3 2.7 1 1 0 1 1 1 0 Serine incorporator (Serinc) Mlo PF03094.15 ETO27221.1 - 6.7 5.0 10.8 0.13 10.7 2.3 2.1 2 0 0 2 2 2 0 Mlo family MIEAP PF16026.5 ETO27222.1 - 0.00029 21.1 2.8 0.0011 19.2 2.2 2.5 1 1 0 1 1 1 1 Mitochondria-eating protein DUF5045 PF16464.5 ETO27222.1 - 0.46 10.8 4.8 2.1 8.7 0.1 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF5045) PH PF00169.29 ETO27223.1 - 1.3e-13 51.4 4.7 1.3e-13 51.4 4.7 2.2 2 1 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO27223.1 - 3.8e-08 33.5 1.2 9.5e-08 32.2 1.2 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO27223.1 - 2.5e-07 31.1 14.7 1.1e-05 25.8 1.3 3.4 2 1 2 4 4 4 2 Pleckstrin homology domain PH_3 PF14593.6 ETO27223.1 - 2.4e-06 27.6 2.0 5.8e-06 26.4 2.0 1.6 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ETO27223.1 - 0.00016 21.9 1.5 0.029 14.6 0.2 2.3 2 0 0 2 2 2 2 Pleckstrin homology domain PH_2 PF08458.10 ETO27223.1 - 0.016 15.5 0.5 0.016 15.5 0.5 1.8 2 0 0 2 2 2 0 Plant pleckstrin homology-like region Colicin_Pyocin PF01320.18 ETO27223.1 - 0.034 14.3 0.5 0.31 11.2 0.0 2.6 2 1 1 3 3 3 0 Colicin immunity protein / pyocin immunity protein F-box-like PF12937.7 ETO27224.1 - 0.0014 18.5 1.7 0.0026 17.6 1.7 1.4 1 0 0 1 1 1 1 F-box-like DUF2796 PF10986.8 ETO27226.1 - 0.0007 19.6 3.4 0.0007 19.6 3.4 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF2796) FAM176 PF14851.6 ETO27226.1 - 0.73 9.5 9.2 0.14 11.9 4.8 1.9 2 0 0 2 2 2 0 FAM176 family UPF0239 PF06783.11 ETO27227.1 - 0.014 15.6 1.0 0.014 15.6 1.0 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0239) Mem_trans PF03547.18 ETO27227.1 - 0.026 12.9 6.7 0.034 12.5 6.7 1.2 1 0 0 1 1 1 0 Membrane transport protein SID-1_RNA_chan PF13965.6 ETO27227.1 - 0.026 12.9 8.5 0.014 13.8 6.9 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Ndc1_Nup PF09531.10 ETO27227.1 - 0.83 8.3 6.8 0.92 8.1 6.8 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 ETO27227.1 - 1.5 7.7 13.2 1.7 7.6 13.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Hid1 PF12722.7 ETO27227.1 - 1.8 6.6 12.1 1.9 6.5 12.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Acatn PF13000.7 ETO27227.1 - 2.6 6.4 6.5 0.49 8.8 2.7 1.6 1 1 1 2 2 2 0 Acetyl-coenzyme A transporter 1 SpoIIIAH PF12685.7 ETO27227.1 - 7.6 6.3 24.3 20 5.0 24.3 1.6 1 1 0 1 1 1 0 SpoIIIAH-like protein GREB1 PF15782.5 ETO27227.1 - 8.1 3.4 15.9 9.1 3.2 15.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Utp14 PF04615.13 ETO27228.1 - 0.15 10.6 23.2 0.2 10.2 23.2 1.2 1 0 0 1 1 1 0 Utp14 protein DUF2207 PF09972.9 ETO27229.1 - 0.0045 15.8 0.7 0.044 12.5 0.7 2.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) DUF3619 PF12279.8 ETO27229.1 - 0.081 13.2 1.5 0.44 10.9 0.0 2.8 4 0 0 4 4 4 0 Protein of unknown function (DUF3619) Peptidase_M56 PF05569.11 ETO27229.1 - 0.17 11.0 0.1 0.17 11.0 0.1 1.9 2 0 0 2 2 2 0 BlaR1 peptidase M56 DUF3671 PF12420.8 ETO27229.1 - 0.88 9.7 9.5 4.2 7.5 4.1 2.8 3 0 0 3 3 3 0 Protein of unknown function vMSA PF00695.19 ETO27229.1 - 1.2 8.2 3.9 1.1 8.2 1.3 2.1 2 0 0 2 2 2 0 Major surface antigen from hepadnavirus RuBisCO_small PF00101.20 ETO27230.1 - 0.0038 17.2 0.0 0.26 11.3 0.0 2.7 2 1 0 2 2 2 2 Ribulose bisphosphate carboxylase, small chain VWA_3 PF13768.6 ETO27231.1 - 1.5e-09 38.0 0.0 2.2e-09 37.5 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO27231.1 - 4.8e-09 36.7 0.0 6.8e-09 36.2 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO27231.1 - 3.3e-08 34.1 0.0 5.1e-08 33.5 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_CoxE PF05762.14 ETO27231.1 - 0.012 15.0 0.0 0.017 14.5 0.0 1.1 1 0 0 1 1 1 0 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 ETO27231.1 - 0.018 15.1 0.0 0.045 13.9 0.0 1.6 1 1 0 1 1 1 0 vWA found in TerF C terminus Copine PF07002.16 ETO27231.1 - 0.02 14.3 0.0 0.027 13.9 0.0 1.2 1 0 0 1 1 1 0 Copine zf-TRAF PF02176.18 ETO27232.1 - 3.2e-06 27.7 3.7 3.2e-06 27.7 3.7 2.8 2 1 1 3 3 3 1 TRAF-type zinc finger DUF725 PF05267.12 ETO27232.1 - 0.0037 17.2 0.7 0.0084 16.1 0.7 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF725) V-ATPase_G PF03179.15 ETO27232.1 - 0.17 12.4 0.3 0.31 11.6 0.3 1.3 1 0 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit zf-C6H2 PF15801.5 ETO27232.1 - 1 9.7 14.6 5.9 7.3 0.1 3.8 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding WD40 PF00400.32 ETO27233.1 - 6.7e-71 232.5 19.5 2.2e-10 40.9 0.1 8.4 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27233.1 - 1.9e-25 89.0 4.7 0.0012 19.1 0.0 7.8 3 1 6 9 9 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27233.1 - 5.3e-18 65.1 2.0 0.032 13.2 0.0 7.2 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27233.1 - 1.1e-05 24.9 11.9 0.054 12.8 0.0 5.0 3 1 1 5 5 5 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO27233.1 - 1.3e-05 24.0 1.3 0.003 16.2 0.1 3.1 1 1 1 3 3 3 1 Cytochrome D1 heme domain Kelch_5 PF13854.6 ETO27233.1 - 2.9e-05 23.9 7.7 0.00099 19.0 0.9 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO27233.1 - 2.9e-05 23.5 7.2 0.0025 17.4 0.7 2.9 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO27233.1 - 0.00012 22.2 12.8 0.078 13.3 0.4 5.8 6 1 1 7 7 6 2 Kelch motif PD40 PF07676.12 ETO27233.1 - 0.00016 21.5 8.3 9.4 6.3 0.0 6.0 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO27233.1 - 0.00021 20.9 1.8 0.00083 19.0 1.8 1.9 1 1 0 1 1 1 1 PQQ-like domain DUF5570 PF17731.1 ETO27233.1 - 0.00047 20.3 4.8 10 6.2 0.0 5.3 3 2 4 7 7 6 2 Family of unknown function (DUF5570) Kelch_3 PF13415.6 ETO27233.1 - 0.00057 20.1 0.1 0.0023 18.2 0.1 2.2 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO27233.1 - 0.00071 19.5 2.8 0.028 14.4 0.3 3.9 3 0 0 3 3 3 1 Galactose oxidase, central domain DUF5046 PF16465.5 ETO27233.1 - 0.0039 16.7 0.8 0.13 11.6 0.0 2.9 2 1 2 4 4 4 2 Domain of unknown function (DUF5046) Proteasome_A_N PF10584.9 ETO27233.1 - 0.028 14.1 0.9 43 3.9 0.0 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Kelch_2 PF07646.15 ETO27233.1 - 0.14 12.2 6.9 2.2 8.4 0.4 3.9 4 0 0 4 4 3 0 Kelch motif SBD PF17882.1 ETO27233.1 - 0.18 11.6 2.5 30 4.5 0.2 3.7 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain Glyco_hydro_31 PF01055.26 ETO27234.1 - 9e-24 84.5 0.3 1.3e-23 83.9 0.3 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 Ion_trans_2 PF07885.16 ETO27236.1 - 4.2e-11 42.6 12.7 4.7e-06 26.5 5.6 2.4 2 0 0 2 2 2 2 Ion channel EF-hand_1 PF00036.32 ETO27236.1 - 3.1e-08 32.6 7.5 6.7e-05 22.2 0.6 2.7 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO27236.1 - 4.9e-08 32.3 3.7 0.00063 19.5 0.2 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO27236.1 - 3.2e-06 27.5 3.0 9.5e-06 26.0 2.9 1.9 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO27236.1 - 9.6e-05 21.7 6.5 0.007 15.8 0.5 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO27236.1 - 0.00012 21.8 3.7 0.058 13.3 0.3 2.6 2 0 0 2 2 2 2 EF-hand domain pair IRK PF01007.20 ETO27236.1 - 0.029 14.2 2.5 0.27 11.0 0.4 2.3 2 0 0 2 2 2 0 Inward rectifier potassium channel transmembrane domain UPF0542 PF15086.6 ETO27237.1 - 0.045 13.7 0.1 0.11 12.4 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 SPX PF03105.19 ETO27238.1 - 2.6e-08 34.2 7.9 3.8e-08 33.7 7.9 1.2 1 0 0 1 1 1 1 SPX domain DUF2151 PF10221.9 ETO27238.1 - 0.23 10.0 0.0 0.23 10.0 0.0 1.8 1 1 0 2 2 2 0 Cell cycle and development regulator Clat_adaptor_s PF01217.20 ETO27239.1 - 0.032 14.1 0.0 0.068 13.1 0.0 1.5 1 0 0 1 1 1 0 Clathrin adaptor complex small chain DUF2514 PF10721.9 ETO27239.1 - 0.075 13.1 4.5 0.11 12.6 4.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2514) DASH_Hsk3 PF08227.11 ETO27239.1 - 0.21 12.0 2.7 14 6.1 0.3 2.9 3 0 0 3 3 3 0 DASH complex subunit Hsk3 like EMP24_GP25L PF01105.24 ETO27239.1 - 0.53 10.2 6.4 0.64 9.9 6.4 1.2 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD UPF0242 PF06785.11 ETO27239.1 - 0.72 9.9 8.8 1.6 8.8 8.8 1.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus RT_RNaseH_2 PF17919.1 ETO27241.1 - 9e-19 67.4 0.0 2e-18 66.3 0.0 1.6 1 0 0 1 1 1 1 RNase H-like domain found in reverse transcriptase RVT_1 PF00078.27 ETO27241.1 - 1e-15 57.8 0.1 1.9e-15 57.0 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) RT_RNaseH PF17917.1 ETO27241.1 - 1.3e-08 35.1 0.2 4.1e-06 27.0 0.0 2.7 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase Pepsin-I3 PF06394.13 ETO27242.1 - 0.11 12.7 1.1 0.17 12.1 0.1 1.7 2 0 0 2 2 2 0 Pepsin inhibitor-3-like repeated domain VP4_2 PF08935.10 ETO27243.1 - 0.28 11.8 5.4 1.9 9.2 0.2 2.7 2 0 0 2 2 2 0 Viral protein VP4 subunit RhoGAP PF00620.27 ETO27244.1 - 8.5e-20 71.1 0.0 1.9e-19 70.0 0.0 1.6 1 0 0 1 1 1 1 RhoGAP domain MAS20 PF02064.15 ETO27245.1 - 1.2 9.2 6.6 2.5 8.2 6.6 1.6 1 0 0 1 1 1 0 MAS20 protein import receptor DUF2098 PF09871.9 ETO27245.1 - 4.9 7.6 11.5 22 5.5 0.0 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) SR-25 PF10500.9 ETO27245.1 - 8.1 6.0 18.9 0.63 9.6 3.5 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein FYRN PF05964.14 ETO27246.1 - 2.1e-13 49.9 0.1 3.8e-13 49.0 0.1 1.5 1 0 0 1 1 1 1 F/Y-rich N-terminus FYRC PF05965.14 ETO27246.1 - 0.00092 19.3 0.0 0.0019 18.3 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus PH PF00169.29 ETO27248.1 - 9e-10 39.0 1.0 1.6e-09 38.2 0.3 1.8 2 0 0 2 2 2 1 PH domain Mcp5_PH PF12814.7 ETO27248.1 - 0.34 11.0 1.9 0.72 10.0 0.3 2.1 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology PH_11 PF15413.6 ETO27248.1 - 0.48 10.9 3.2 0.49 10.8 0.6 2.4 2 1 0 2 2 2 0 Pleckstrin homology domain ATG7_N PF16420.5 ETO27249.1 - 2.7e-17 63.4 0.3 2.7e-17 63.4 0.3 2.1 2 0 0 2 2 2 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus ThiF PF00899.21 ETO27249.1 - 1e-10 41.4 10.0 6.1e-05 22.5 0.1 3.5 3 1 1 4 4 4 3 ThiF family Menin PF05053.13 ETO27249.1 - 3.5 5.9 10.5 1.1 7.6 2.2 2.3 2 0 0 2 2 2 0 Menin WD40 PF00400.32 ETO27250.1 - 4.7e-45 150.7 22.4 1.3e-08 35.3 0.2 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27250.1 - 1e-20 73.8 5.4 0.0055 17.0 0.0 6.7 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27250.1 - 1.9e-09 36.7 5.9 0.0025 16.5 1.3 5.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO27250.1 - 4.4e-09 35.7 2.5 0.0024 16.9 0.0 5.1 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27250.1 - 3e-07 30.1 11.0 0.0046 16.3 0.2 4.5 2 1 4 6 6 6 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO27250.1 - 4.9e-07 28.6 0.1 0.0092 14.5 0.0 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO27250.1 - 1.3e-05 24.4 4.2 6.9 5.5 0.0 5.2 1 1 4 6 6 6 3 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 ETO27250.1 - 0.0014 18.3 0.1 0.015 14.9 0.1 2.5 1 1 0 1 1 1 1 PQQ-like domain Me-amine-dh_H PF06433.11 ETO27250.1 - 0.027 13.3 0.4 2 7.2 0.0 2.9 2 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO27250.1 - 0.039 13.9 1.2 21 5.2 0.0 3.5 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF1815 PF08844.10 ETO27250.1 - 0.06 13.3 0.1 5.6 7.0 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1815) PQQ PF01011.21 ETO27250.1 - 0.074 13.0 0.0 85 3.3 0.0 4.6 6 0 0 6 6 6 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETO27250.1 - 0.38 10.5 1.4 75 3.1 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF4909 PF16253.5 ETO27250.1 - 0.85 9.5 5.2 1.5 8.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4909) WD40 PF00400.32 ETO27251.1 - 7.2e-56 184.9 22.1 3.5e-10 40.3 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27251.1 - 6.5e-19 68.0 4.4 0.0024 18.2 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27251.1 - 1.1e-12 47.6 0.3 0.018 14.0 0.0 5.8 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO27251.1 - 3e-10 40.3 1.1 0.0077 16.1 0.1 3.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO27251.1 - 2.3e-08 33.0 0.1 0.018 13.6 0.0 3.3 1 1 3 4 4 4 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO27251.1 - 8.9e-08 31.2 8.6 0.12 10.9 0.1 5.1 1 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO27251.1 - 5.5e-07 29.4 3.2 0.44 10.6 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO27251.1 - 1.3e-06 28.5 2.4 2.3 8.4 0.0 5.0 1 1 3 5 5 5 2 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO27251.1 - 6.8e-06 25.6 0.0 0.025 13.9 0.0 2.7 2 1 1 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 ETO27251.1 - 0.0011 17.7 2.7 0.11 11.2 0.4 3.2 1 1 1 3 3 3 1 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO27251.1 - 0.0022 17.1 1.3 0.97 8.4 0.4 2.8 1 1 1 3 3 3 2 Coatomer WD associated region DPPIV_N PF00930.21 ETO27251.1 - 0.0051 15.6 0.0 4.8 5.8 0.0 3.1 1 1 1 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region BBS2_Mid PF14783.6 ETO27251.1 - 0.1 12.6 10.1 11 6.1 0.1 5.8 2 2 3 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Ricin_B_lectin PF00652.22 ETO27251.1 - 0.11 12.8 5.2 16 5.8 0.0 3.7 1 1 3 4 4 4 0 Ricin-type beta-trefoil lectin domain Proteasome_A_N PF10584.9 ETO27251.1 - 0.22 11.2 4.7 41 4.0 0.4 3.9 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF4999 PF16390.5 ETO27251.1 - 2.1 8.7 4.2 70 3.8 0.1 4.2 5 0 0 5 5 5 0 Domain of unknown function G8 PF10162.9 ETO27253.1 - 4.1e-25 88.2 1.2 9.9e-25 87.0 0.2 2.1 2 1 0 2 2 2 1 G8 domain B_lectin PF01453.24 ETO27253.1 - 0.11 13.0 2.4 0.6 10.7 0.0 2.7 3 1 0 3 3 3 0 D-mannose binding lectin Kelch_6 PF13964.6 ETO27254.1 - 4.5e-06 26.7 1.7 0.021 15.1 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO27254.1 - 4.6e-05 23.2 2.7 0.093 12.8 0.2 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO27254.1 - 5.5e-05 22.7 2.0 0.02 14.4 0.1 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO27254.1 - 0.0031 17.5 0.2 0.026 14.5 0.1 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO27254.1 - 0.16 12.0 3.3 4.8 7.3 0.4 3.8 4 0 0 4 4 4 0 Kelch motif EF-hand_7 PF13499.6 ETO27255.1 - 1.9e-07 31.4 1.3 6.6e-07 29.7 0.5 2.3 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO27255.1 - 4.8e-05 23.0 1.7 0.16 11.9 0.2 3.7 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 ETO27255.1 - 0.012 15.1 1.4 0.26 10.9 0.2 3.3 4 0 0 4 4 4 0 EF hand SPARC_Ca_bdg PF10591.9 ETO27255.1 - 0.016 15.5 0.1 0.14 12.4 0.0 2.1 2 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO27255.1 - 0.03 13.8 0.0 0.31 10.6 0.0 2.4 2 0 0 2 2 2 0 EF hand RST PF12174.8 ETO27255.1 - 0.031 14.2 0.1 0.13 12.2 0.0 2.1 2 1 0 2 2 2 0 RCD1-SRO-TAF4 (RST) plant domain Sporozoite_P67 PF05642.11 ETO27256.1 - 3.5 5.6 8.2 4.4 5.3 8.2 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF3899 PF13038.6 ETO27256.1 - 7 7.2 9.1 2.8 8.5 2.8 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) Pkinase PF00069.25 ETO27257.1 - 4.2e-30 105.0 0.0 3.3e-17 62.7 0.0 3.1 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27257.1 - 5.1e-17 62.0 0.0 1.1e-08 34.8 0.0 3.1 3 0 0 3 3 3 3 Protein tyrosine kinase Seadorna_VP7 PF07387.11 ETO27257.1 - 0.019 14.0 0.0 0.12 11.4 0.0 2.1 2 0 0 2 2 2 0 Seadornavirus VP7 Ion_trans PF00520.31 ETO27258.1 - 4.2e-25 88.4 57.6 2.8e-19 69.3 22.3 3.2 3 0 0 3 3 3 3 Ion transport protein EF-hand_6 PF13405.6 ETO27258.1 - 0.00079 19.2 2.5 0.8 9.8 0.9 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO27258.1 - 0.0024 17.3 3.5 0.88 9.3 1.2 3.0 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO27258.1 - 0.012 16.0 2.8 3.8 8.1 0.5 2.8 2 0 0 2 2 2 0 EF-hand domain pair PH PF00169.29 ETO27259.1 - 9.3e-06 26.1 2.4 9.3e-06 26.1 2.4 2.1 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO27259.1 - 0.032 14.5 0.2 0.1 12.9 0.2 1.9 1 0 0 1 1 1 0 Pleckstrin homology domain AAA_22 PF13401.6 ETO27259.1 - 0.097 12.9 0.3 0.38 11.0 0.1 2.2 2 0 0 2 2 2 0 AAA domain CHD5 PF04420.14 ETO27259.1 - 0.89 9.4 3.9 3 7.7 3.9 1.9 1 0 0 1 1 1 0 CHD5-like protein Actin PF00022.19 ETO27260.1 - 3.4e-108 361.8 0.0 4e-108 361.6 0.0 1.0 1 0 0 1 1 1 1 Actin ThiF PF00899.21 ETO27260.1 - 0.14 11.4 0.0 0.22 10.8 0.0 1.3 1 0 0 1 1 1 0 ThiF family Spc7 PF08317.11 ETO27261.1 - 0.056 12.3 2.4 0.07 12.0 2.4 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF5517 PF17639.2 ETO27261.1 - 0.068 13.5 1.2 0.11 12.8 1.2 1.5 1 1 0 1 1 1 0 Family of unknown function (DUF5517) ESM4 PF15952.5 ETO27261.1 - 0.29 11.6 2.7 0.31 11.5 2.7 1.0 1 0 0 1 1 1 0 Enhancer of split M4 family Pkinase PF00069.25 ETO27262.1 - 1.4e-36 126.2 8.7 4.6e-26 91.8 0.6 4.2 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27262.1 - 1.4e-20 73.7 3.1 8.1e-12 45.0 0.7 3.9 3 1 0 3 3 3 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO27262.1 - 0.0015 18.0 0.0 0.1 11.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Kdo PF06293.14 ETO27262.1 - 0.0044 16.4 0.3 0.008 15.6 0.3 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO27262.1 - 0.025 14.5 0.1 0.047 13.6 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF1664 PF07889.12 ETO27263.1 - 0.016 15.2 20.9 0.095 12.7 3.2 3.6 2 1 0 3 3 3 0 Protein of unknown function (DUF1664) PRKG1_interact PF15898.5 ETO27263.1 - 0.031 15.2 11.6 0.031 15.2 11.6 3.6 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Type2_restr_D3 PF16902.5 ETO27263.1 - 0.042 13.8 0.6 0.53 10.2 0.1 2.5 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain TPR_MLP1_2 PF07926.12 ETO27263.1 - 0.14 12.2 33.9 1.3 9.1 7.6 3.6 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein FUSC PF04632.12 ETO27263.1 - 0.15 10.6 5.4 0.19 10.2 5.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family YkyA PF10368.9 ETO27263.1 - 0.16 11.6 29.1 0.84 9.3 8.2 3.1 2 1 1 3 3 3 0 Putative cell-wall binding lipoprotein EzrA PF06160.12 ETO27263.1 - 0.23 9.6 28.2 0.49 8.5 11.4 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Spc7 PF08317.11 ETO27263.1 - 0.36 9.7 33.0 0.83 8.5 23.6 2.7 1 1 0 2 2 2 0 Spc7 kinetochore protein DUF724 PF05266.14 ETO27263.1 - 0.45 10.3 24.3 0.024 14.5 13.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF724) MAD PF05557.13 ETO27263.1 - 0.51 8.6 33.6 0.33 9.3 2.4 2.0 1 1 1 2 2 2 0 Mitotic checkpoint protein DUF3584 PF12128.8 ETO27263.1 - 0.56 7.7 26.5 0.078 10.5 19.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3584) Baculo_PEP_C PF04513.12 ETO27263.1 - 0.59 10.2 10.6 28 4.8 8.2 3.0 2 1 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus HMMR_N PF15905.5 ETO27263.1 - 1 8.8 33.1 0.35 10.3 18.0 2.2 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor N-terminal DUF148 PF02520.17 ETO27263.1 - 1.1 9.3 21.4 4.3 7.5 2.9 3.2 1 1 2 3 3 3 0 Domain of unknown function DUF148 Minor_capsid_3 PF12691.7 ETO27263.1 - 1.3 9.4 5.9 0.54 10.6 1.0 2.5 1 1 2 3 3 3 0 Minor capsid protein from bacteriophage Tropomyosin PF00261.20 ETO27263.1 - 1.5 8.1 31.8 1.9 7.8 31.8 1.1 1 0 0 1 1 1 0 Tropomyosin FapA PF03961.13 ETO27263.1 - 1.6 7.3 24.1 0.65 8.5 14.5 2.2 1 1 0 2 2 2 0 Flagellar Assembly Protein A DUF3450 PF11932.8 ETO27263.1 - 1.7 7.9 27.5 0.4 10.0 19.3 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) IFT57 PF10498.9 ETO27263.1 - 2.1 7.2 31.1 2.1 7.3 21.1 2.8 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 DHR10 PF18595.1 ETO27263.1 - 2.3 8.3 39.2 0.69 10.0 7.2 3.4 2 1 1 3 3 3 0 Designed helical repeat protein 10 domain COG2 PF06148.11 ETO27263.1 - 2.4 8.2 21.8 0.75 9.9 1.1 3.6 1 1 3 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 ISG65-75 PF11727.8 ETO27263.1 - 2.5 7.3 16.0 0.57 9.4 10.5 2.1 1 1 1 2 2 2 0 Invariant surface glycoprotein LXG PF04740.12 ETO27263.1 - 2.6 7.7 20.8 0.9 9.2 9.7 2.8 2 1 1 3 3 3 0 LXG domain of WXG superfamily Bacillus_HBL PF05791.11 ETO27263.1 - 2.6 7.8 20.5 7.1 6.4 6.6 3.0 1 1 2 3 3 3 0 Bacillus haemolytic enterotoxin (HBL) ING PF12998.7 ETO27263.1 - 2.8 8.6 18.9 0.16 12.6 10.6 2.5 1 1 1 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding DUF4407 PF14362.6 ETO27263.1 - 3 7.1 21.9 18 4.5 21.9 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Tropomyosin_1 PF12718.7 ETO27263.1 - 3.3 7.9 32.3 1.3 9.1 0.5 2.7 2 1 0 2 2 2 0 Tropomyosin like Lectin_N PF03954.14 ETO27263.1 - 3.5 7.4 15.5 1.2 8.9 1.6 2.9 2 1 0 3 3 3 0 Hepatic lectin, N-terminal domain DUF4201 PF13870.6 ETO27263.1 - 3.5 7.3 31.8 0.65 9.7 18.0 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4201) TMPIT PF07851.13 ETO27263.1 - 3.7 6.7 25.5 1.6 7.9 11.6 2.7 1 1 2 3 3 3 0 TMPIT-like protein Golgin_A5 PF09787.9 ETO27263.1 - 4.5 6.7 34.1 0.32 10.4 24.5 2.1 1 1 1 2 2 2 0 Golgin subfamily A member 5 Exonuc_VII_L PF02601.15 ETO27263.1 - 8 5.9 26.7 11 5.5 20.0 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit HrpB7 PF09486.10 ETO27263.1 - 9.1 6.6 21.7 15 5.9 1.1 3.1 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) 2OG-FeII_Oxy_3 PF13640.6 ETO27264.1 - 1.1e-09 39.0 0.0 2e-09 38.2 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_5 PF13759.6 ETO27264.1 - 0.00065 20.1 0.0 0.0047 17.3 0.0 2.3 1 1 0 1 1 1 1 Putative 2OG-Fe(II) oxygenase Oxygenase-NA PF09859.9 ETO27264.1 - 0.00083 18.9 0.1 0.022 14.3 0.0 2.5 1 1 0 2 2 2 1 Oxygenase, catalysing oxidative methylation of damaged DNA DUF2237 PF09996.9 ETO27264.1 - 0.011 15.7 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) Asp_Arg_Hydrox PF05118.15 ETO27264.1 - 0.044 13.6 0.0 0.072 12.9 0.0 1.4 1 0 0 1 1 1 0 Aspartyl/Asparaginyl beta-hydroxylase Cupin_2 PF07883.11 ETO27264.1 - 0.083 12.6 0.0 0.2 11.4 0.0 1.7 1 1 0 1 1 1 0 Cupin domain 2OG-FeII_Oxy_4 PF13661.6 ETO27264.1 - 0.093 13.4 0.0 0.16 12.7 0.0 1.4 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Mito_carr PF00153.27 ETO27266.1 - 2.1e-18 66.0 2.7 2.7e-15 56.0 0.2 2.4 2 1 0 2 2 2 2 Mitochondrial carrier protein AF-4 PF05110.13 ETO27266.1 - 0.034 12.3 2.3 0.047 11.8 2.3 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein DUF4598 PF15370.6 ETO27266.1 - 0.041 14.4 0.5 0.11 13.0 0.5 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4598) RAMP4 PF06624.12 ETO27266.1 - 0.068 13.3 1.1 0.068 13.3 1.1 2.2 2 0 0 2 2 2 0 Ribosome associated membrane protein RAMP4 DUF2207 PF09972.9 ETO27266.1 - 0.13 11.0 1.2 0.46 9.2 2.0 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MFMR_assoc PF16596.5 ETO27266.1 - 0.39 11.2 6.2 0.6 10.6 6.2 1.2 1 0 0 1 1 1 0 Disordered region downstream of MFMR Pex26 PF07163.12 ETO27267.1 - 0.016 14.5 2.4 0.028 13.8 2.4 1.4 1 0 0 1 1 1 0 Pex26 protein WD40 PF00400.32 ETO27269.1 - 3.8e-25 87.7 8.7 3e-08 34.2 0.6 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27269.1 - 8.8e-16 58.0 1.9 0.00015 22.0 0.0 5.1 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27269.1 - 2.4e-07 30.0 1.8 0.063 12.2 0.0 4.1 1 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO27269.1 - 3.6e-07 30.2 0.2 0.00092 19.1 0.0 2.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO27269.1 - 0.00023 20.6 1.0 0.3 10.4 0.0 3.1 1 1 1 3 3 3 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO27269.1 - 0.00057 19.0 1.8 0.01 14.9 0.1 2.5 1 1 1 2 2 2 1 Coatomer WD associated region NHL PF01436.21 ETO27269.1 - 0.00077 19.4 0.0 6.5 7.0 0.0 3.6 3 0 0 3 3 3 2 NHL repeat Cytochrom_D1 PF02239.16 ETO27269.1 - 0.002 16.7 0.2 0.0069 15.0 0.1 1.9 1 1 1 2 2 2 1 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO27269.1 - 0.0031 16.9 0.5 0.12 11.7 0.1 2.3 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ETO27269.1 - 0.0046 15.9 1.3 1.3 7.9 0.0 2.6 2 1 1 3 3 3 2 Partner and localizer of BRCA2 WD40 domain Methyltransf_3 PF01596.17 ETO27269.1 - 0.089 12.0 0.0 2.5 7.2 0.0 2.2 1 1 0 2 2 2 0 O-methyltransferase PD40 PF07676.12 ETO27269.1 - 0.094 12.7 2.3 16 5.6 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO27269.1 - 0.26 11.0 1.6 6.1 6.6 0.0 3.2 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature TPR_12 PF13424.6 ETO27270.1 - 6.2e-26 90.5 0.4 4.8e-10 39.6 0.0 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27270.1 - 2.7e-10 39.8 0.0 5.4e-05 22.9 0.1 4.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27270.1 - 7.6e-08 31.9 5.2 0.00028 20.6 0.5 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27270.1 - 1.4e-07 31.1 2.2 0.004 17.2 0.1 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27270.1 - 1.5e-07 31.0 6.0 0.0036 17.4 0.3 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27270.1 - 2.5e-07 30.3 0.5 0.00068 19.5 0.1 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO27270.1 - 0.001 18.5 0.0 0.002 17.6 0.0 1.4 1 0 0 1 1 1 1 MalT-like TPR region Pet100 PF09803.9 ETO27270.1 - 0.046 14.2 0.2 0.13 12.7 0.2 1.8 1 0 0 1 1 1 0 Pet100 SecD-TM1 PF13721.6 ETO27270.1 - 0.046 14.2 1.8 0.14 12.6 1.8 1.8 1 0 0 1 1 1 0 SecD export protein N-terminal TM region TPR_17 PF13431.6 ETO27270.1 - 0.05 14.0 0.1 1.1 9.8 0.1 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF4404 PF14357.6 ETO27270.1 - 0.053 14.2 3.6 0.47 11.1 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4404) TPR_11 PF13414.6 ETO27270.1 - 0.086 12.5 0.4 46 3.8 0.0 3.7 3 1 1 4 4 4 0 TPR repeat ALMT PF11744.8 ETO27271.1 - 0.005 15.7 9.7 0.0057 15.5 9.7 1.0 1 0 0 1 1 1 1 Aluminium activated malate transporter DDHD PF02862.17 ETO27271.1 - 0.15 12.2 4.7 0.18 11.9 4.7 1.1 1 0 0 1 1 1 0 DDHD domain Tae4 PF14113.6 ETO27271.1 - 0.23 11.7 3.7 0.32 11.2 3.7 1.3 1 0 0 1 1 1 0 Type VI secretion system (T6SS), amidase effector protein 4 Vfa1 PF08432.10 ETO27271.1 - 0.37 11.1 17.7 0.46 10.8 17.7 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 YqzE PF14038.6 ETO27271.1 - 1.3 9.1 16.1 5.1 7.2 11.8 2.6 2 0 0 2 2 2 0 YqzE-like protein Mog1 PF04603.12 ETO27271.1 - 1.4 9.3 6.5 2.2 8.6 6.5 1.3 1 0 0 1 1 1 0 Ran-interacting Mog1 protein Kinesin PF00225.23 ETO27272.1 - 2.1e-13 49.9 0.0 2.3e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO27272.1 - 1.1e-09 38.4 0.1 1.4e-09 38.0 0.1 1.1 1 0 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 ETO27273.1 - 8.9e-09 34.7 0.0 2.1e-08 33.5 0.0 1.7 1 1 0 1 1 1 1 Kinesin motor domain DMAP_binding PF06464.11 ETO27274.1 - 0.0078 17.0 3.5 0.1 13.4 0.3 3.0 2 0 0 2 2 2 1 DMAP1-binding Domain PHA_gran_rgn PF09650.10 ETO27274.1 - 0.038 14.3 0.5 0.14 12.4 0.0 2.1 2 0 0 2 2 2 0 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn) VWD PF00094.25 ETO27274.1 - 0.053 13.8 0.1 0.053 13.8 0.1 2.7 2 1 1 3 3 3 0 von Willebrand factor type D domain Mic1 PF07035.12 ETO27275.1 - 0.00027 20.7 0.6 0.0011 18.7 0.2 2.0 2 0 0 2 2 2 1 Colon cancer-associated protein Mic1-like DUF4148 PF13663.6 ETO27276.1 - 0.034 14.3 0.4 0.065 13.4 0.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4148) DUF4685 PF15737.5 ETO27276.1 - 6.2 7.3 8.0 4 7.9 0.7 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4685) Exostosin PF03016.15 ETO27278.1 - 0.07 12.3 2.3 0.25 10.5 2.3 1.8 1 1 0 1 1 1 0 Exostosin family PDDEXK_3 PF13366.6 ETO27278.1 - 0.12 12.7 0.0 0.31 11.4 0.0 1.6 1 0 0 1 1 1 0 PD-(D/E)XK nuclease superfamily V_ATPase_I PF01496.19 ETO27279.1 - 0.001 17.2 1.1 0.001 17.1 1.1 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF507 PF04368.13 ETO27279.1 - 0.014 15.4 3.8 0.021 14.7 3.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF507) Muted PF14942.6 ETO27279.1 - 0.041 14.2 8.0 0.061 13.7 8.0 1.4 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein RasGEF_N_2 PF14663.6 ETO27279.1 - 0.044 14.2 1.3 0.71 10.3 0.6 2.3 1 1 1 2 2 2 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain P4Ha_N PF08336.11 ETO27279.1 - 0.044 13.8 1.4 0.073 13.1 1.4 1.4 1 0 0 1 1 1 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region ThiD2 PF17792.1 ETO27279.1 - 0.046 14.2 2.1 0.083 13.4 2.1 1.4 1 0 0 1 1 1 0 ThiD2 family SASA PF03629.18 ETO27279.1 - 0.059 13.0 0.2 0.074 12.7 0.2 1.2 1 0 0 1 1 1 0 Carbohydrate esterase, sialic acid-specific acetylesterase TINF2_N PF14973.6 ETO27279.1 - 0.21 11.9 2.6 0.43 10.9 2.6 1.5 1 0 0 1 1 1 0 TERF1-interacting nuclear factor 2 N-terminus TMPIT PF07851.13 ETO27279.1 - 4.5 6.4 6.8 6.8 5.8 6.8 1.2 1 0 0 1 1 1 0 TMPIT-like protein TB2_DP1_HVA22 PF03134.19 ETO27280.1 - 1.1e-09 38.1 4.7 1.1e-09 38.1 4.7 2.9 3 1 0 3 3 3 1 TB2/DP1, HVA22 family EAL PF00563.20 ETO27281.1 - 6.6e-43 146.9 0.2 1.3e-22 80.5 0.1 2.0 1 1 1 2 2 2 2 EAL domain UBA PF00627.31 ETO27281.1 - 0.0056 16.6 0.1 0.66 9.9 0.0 2.4 2 0 0 2 2 2 2 UBA/TS-N domain YL1 PF05764.13 ETO27282.1 - 0.0057 16.8 15.3 0.0057 16.8 15.3 1.6 2 0 0 2 2 2 1 YL1 nuclear protein DUF667 PF05018.13 ETO27282.1 - 0.0072 16.1 3.7 0.011 15.4 3.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF667) Nop14 PF04147.12 ETO27282.1 - 0.29 9.3 25.0 0.34 9.1 25.0 1.1 1 0 0 1 1 1 0 Nop14-like family PRIMA1 PF16101.5 ETO27282.1 - 0.63 10.1 7.5 1.2 9.1 7.5 1.5 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 BUD22 PF09073.10 ETO27282.1 - 0.87 8.9 18.7 1.2 8.4 18.7 1.2 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ETO27282.1 - 0.89 8.9 23.9 1.5 8.2 23.9 1.4 1 0 0 1 1 1 0 SDA1 Merozoite_SPAM PF07133.11 ETO27282.1 - 2.2 8.2 40.1 3.4 7.6 40.1 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) CDC45 PF02724.14 ETO27282.1 - 3.1 6.0 22.9 3.8 5.7 22.9 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO27282.1 - 3.6 5.6 13.2 5.3 5.0 13.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TFIIF_alpha PF05793.12 ETO27282.1 - 5.2 5.5 26.3 7.2 5.1 26.3 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Pox_Ag35 PF03286.14 ETO27282.1 - 7.5 6.3 17.0 12 5.6 17.0 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DHHC PF01529.20 ETO27284.1 - 5.6e-32 110.7 20.3 3.7e-30 104.8 16.9 2.6 2 0 0 2 2 2 2 DHHC palmitoyltransferase CCSMST1 PF15013.6 ETO27284.1 - 0.016 15.4 1.8 1.6 9.0 0.0 2.9 3 0 0 3 3 3 0 CCSMST1 family DUF3439 PF11921.8 ETO27285.1 - 0.75 9.8 7.0 1.6 8.8 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Pkinase PF00069.25 ETO27286.1 - 9.2e-19 67.8 0.0 1.1e-18 67.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27286.1 - 1.1e-05 24.9 0.0 1.2e-05 24.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO27287.1 - 1.9e-25 89.7 0.1 2e-25 89.6 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27287.1 - 2.7e-16 59.6 0.0 3e-16 59.5 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO27287.1 - 0.00034 20.0 0.0 0.00037 19.9 0.0 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO27287.1 - 0.00076 19.5 0.4 0.0018 18.2 0.3 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO27287.1 - 0.0012 17.8 0.0 0.0016 17.5 0.0 1.3 1 1 0 1 1 1 1 Haspin like kinase domain RIO1 PF01163.22 ETO27287.1 - 0.0024 17.5 0.0 0.003 17.2 0.0 1.3 1 1 0 1 1 1 1 RIO1 family Lipase_3 PF01764.25 ETO27288.1 - 2.1e-22 79.5 0.0 3.7e-22 78.7 0.0 1.3 1 0 0 1 1 1 1 Lipase (class 3) DUF2974 PF11187.8 ETO27288.1 - 7.5e-05 22.4 0.0 0.00016 21.3 0.0 1.6 1 1 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_6 PF12697.7 ETO27288.1 - 0.041 14.5 0.0 0.046 14.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family SAM_1 PF00536.30 ETO27290.1 - 1.3e-09 38.3 0.3 1.3e-09 38.3 0.3 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO27290.1 - 6.7e-07 29.3 0.3 6.7e-07 29.3 0.3 2.5 3 0 0 3 3 3 1 SAM domain (Sterile alpha motif) DUF3450 PF11932.8 ETO27290.1 - 0.085 12.1 25.2 0.19 11.0 25.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) Neur_chan_memb PF02932.16 ETO27290.1 - 0.095 12.7 12.3 0.029 14.4 7.8 1.9 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Laminin_II PF06009.12 ETO27290.1 - 0.19 11.7 9.9 0.48 10.5 9.9 1.7 1 0 0 1 1 1 0 Laminin Domain II DUF3037 PF11236.8 ETO27290.1 - 1.3 9.5 7.9 4.2 7.8 4.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3037) YtxH PF12732.7 ETO27290.1 - 1.9 9.1 8.6 1.5e+02 3.0 8.6 3.2 1 1 0 1 1 1 0 YtxH-like protein HeLo PF14479.6 ETO27290.1 - 2.6 7.9 17.2 0.37 10.6 12.8 1.8 1 1 1 2 2 2 0 Prion-inhibition and propagation DUF4407 PF14362.6 ETO27290.1 - 7.7 5.8 22.1 12 5.1 22.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Utp14 PF04615.13 ETO27291.1 - 0.00045 18.9 24.0 0.00057 18.6 24.0 1.2 1 0 0 1 1 1 1 Utp14 protein TFIIA PF03153.13 ETO27291.1 - 0.00098 19.2 21.8 0.0013 18.8 21.8 1.1 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit COG2 PF06148.11 ETO27291.1 - 0.021 14.9 4.8 0.053 13.6 4.8 1.7 1 0 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 BUD22 PF09073.10 ETO27291.1 - 0.029 13.7 25.2 0.04 13.3 25.2 1.2 1 0 0 1 1 1 0 BUD22 RPN2_C PF18004.1 ETO27291.1 - 0.047 13.6 21.1 0.22 11.4 10.4 2.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain LapA_dom PF06305.11 ETO27291.1 - 0.072 12.9 0.0 0.072 12.9 0.0 2.8 4 0 0 4 4 2 0 Lipopolysaccharide assembly protein A domain GTP-bdg_M PF16360.5 ETO27291.1 - 0.084 13.5 4.0 0.33 11.6 0.2 3.2 3 0 0 3 3 3 0 GTP-binding GTPase Middle Region PP2C_C PF07830.13 ETO27291.1 - 0.79 10.2 3.8 3.1 8.3 3.8 2.0 1 0 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain DUF913 PF06025.12 ETO27291.1 - 3.7 6.4 12.3 0.81 8.6 6.0 2.3 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Connexin PF00029.19 ETO27291.1 - 3.9 7.2 10.8 12 5.6 0.3 2.4 2 0 0 2 2 2 0 Connexin PBP1_TM PF14812.6 ETO27291.1 - 7.5 7.0 22.0 0.9 10.0 14.4 2.9 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FYDLN_acid PF09538.10 ETO27291.1 - 10 6.9 21.9 13 6.5 15.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) DUF5320 PF17253.2 ETO27291.1 - 10 7.3 9.6 28 5.9 0.0 3.6 4 0 0 4 4 4 0 Family of unknown function (DUF5320) PUB PF09409.10 ETO27292.1 - 2.2e-06 27.5 0.1 6.7e-06 25.9 0.1 1.8 1 0 0 1 1 1 1 PUB domain Phostensin PF13914.6 ETO27292.1 - 0.019 15.6 0.0 0.039 14.6 0.0 1.6 1 0 0 1 1 1 0 Phostensin PP1-binding and SH3-binding region DUF2357 PF09823.9 ETO27292.1 - 0.035 13.4 3.7 0.07 12.4 0.9 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF2357) MDD_C PF18376.1 ETO27293.1 - 1.2e-36 126.2 0.0 1.4e-36 126.0 0.0 1.1 1 0 0 1 1 1 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain GHMP_kinases_N PF00288.26 ETO27294.1 - 6.2e-06 26.4 1.3 1.3e-05 25.4 1.3 1.6 1 0 0 1 1 1 1 GHMP kinases N terminal domain MDD_C PF18376.1 ETO27294.1 - 0.0012 18.6 1.2 0.0022 17.7 0.3 1.9 2 0 0 2 2 2 1 Mevalonate 5-diphosphate decarboxylase C-terminal domain Kelch_6 PF13964.6 ETO27297.1 - 0.015 15.6 0.1 0.051 13.9 0.1 1.8 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO27298.1 - 7.3e-06 25.9 0.0 0.00059 19.8 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO27298.1 - 1.9e-05 24.7 0.7 0.12 12.7 0.1 3.6 3 1 1 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO27298.1 - 7.5e-05 22.6 0.6 0.0002 21.2 0.2 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO27298.1 - 0.00097 18.7 0.3 0.0033 17.0 0.1 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO27298.1 - 0.011 16.0 0.0 0.026 14.8 0.0 1.7 1 0 0 1 1 1 0 Galactose oxidase, central domain WD40 PF00400.32 ETO27299.1 - 1.1e-44 149.5 8.9 8.9e-10 39.0 0.3 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27299.1 - 2.3e-13 50.2 0.3 0.013 15.8 0.0 4.8 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27299.1 - 6.6e-10 38.5 0.6 0.041 12.8 0.0 4.5 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO27299.1 - 1.5e-05 25.0 0.1 9.4e-05 22.4 0.0 1.9 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO27299.1 - 2.3e-05 23.9 0.3 0.038 13.3 0.0 2.1 2 0 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO27299.1 - 0.0018 18.2 2.9 0.15 12.1 0.0 3.1 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO27299.1 - 0.0059 15.7 0.1 0.2 10.6 0.0 2.1 1 1 0 1 1 1 1 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO27299.1 - 0.031 13.0 3.6 1.3 7.7 0.2 3.2 1 1 3 4 4 4 0 Nup133 N terminal like Nbas_N PF15492.6 ETO27299.1 - 0.043 13.1 0.3 7.8 5.7 0.0 2.4 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO27299.1 - 0.072 12.8 0.5 9 6.1 0.0 2.9 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO27299.1 - 0.23 11.6 2.1 20 5.3 0.0 2.8 2 2 1 3 3 3 0 Family of unknown function (DUF5570) Band_7 PF01145.25 ETO27300.1 - 1e-26 94.0 0.3 1.3e-26 93.7 0.3 1.1 1 0 0 1 1 1 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ETO27300.1 - 0.00048 19.9 0.2 0.00086 19.1 0.2 1.5 1 1 0 1 1 1 1 SPFH domain-Band 7 family RRM_1 PF00076.22 ETO27302.1 - 4.6e-05 23.2 0.0 7.9e-05 22.4 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO27302.1 - 0.0074 16.1 0.0 0.013 15.3 0.0 1.4 1 1 0 1 1 1 1 Occluded RNA-recognition motif AJAP1_PANP_C PF15298.6 ETO27303.1 - 0.015 15.5 5.0 0.022 15.0 5.0 1.2 1 0 0 1 1 1 0 AJAP1/PANP C-terminus Mucin PF01456.17 ETO27303.1 - 0.029 14.4 8.3 0.042 13.8 8.3 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein FSA_C PF10479.9 ETO27303.1 - 0.074 11.2 2.9 0.095 10.8 2.9 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Dicty_REP PF05086.12 ETO27303.1 - 0.33 8.9 9.6 0.012 13.6 3.5 1.6 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 ETO27303.1 - 1.9 6.6 8.5 2.4 6.3 8.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO27303.1 - 2 8.4 10.4 3.9 7.5 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF2407_C PF13373.6 ETO27303.1 - 2.3 8.4 5.7 0.55 10.4 0.4 2.1 2 0 0 2 2 2 0 DUF2407 C-terminal domain Abhydro_lipase PF04083.16 ETO27304.1 - 2.2e-21 75.2 0.0 4.6e-21 74.2 0.0 1.6 1 0 0 1 1 1 1 Partial alpha/beta-hydrolase lipase region Abhydrolase_1 PF00561.20 ETO27304.1 - 1.2e-10 41.5 0.0 3e-10 40.2 0.0 1.7 2 0 0 2 2 2 1 alpha/beta hydrolase fold Chlorophyllase2 PF12740.7 ETO27304.1 - 0.11 11.4 0.0 0.18 10.7 0.0 1.3 1 0 0 1 1 1 0 Chlorophyllase enzyme ORC6 PF05460.13 ETO27305.1 - 0.0026 17.1 10.6 0.0032 16.8 10.6 1.2 1 0 0 1 1 1 1 Origin recognition complex subunit 6 (ORC6) RSRP PF17069.5 ETO27305.1 - 0.0052 16.4 48.3 0.0079 15.8 48.3 1.2 1 0 0 1 1 1 1 Arginine/Serine-Rich protein 1 LAP1C PF05609.12 ETO27305.1 - 0.46 9.5 12.0 0.54 9.3 12.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Peptidase_S64 PF08192.11 ETO27305.1 - 0.51 8.8 16.9 0.67 8.4 16.9 1.1 1 0 0 1 1 1 0 Peptidase family S64 SRP-alpha_N PF04086.13 ETO27305.1 - 0.76 9.6 26.3 1 9.3 26.3 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal SOBP PF15279.6 ETO27305.1 - 7.3 7.1 10.5 11 6.6 10.5 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein RRM_1 PF00076.22 ETO27306.1 - 7.3e-13 48.1 0.5 4.8e-11 42.3 0.5 2.3 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO27306.1 - 0.013 15.4 0.0 0.028 14.3 0.0 1.6 1 1 0 1 1 1 0 Occluded RNA-recognition motif Elong_Iki1 PF10483.9 ETO27306.1 - 0.03 13.8 0.1 0.036 13.6 0.1 1.1 1 0 0 1 1 1 0 Elongator subunit Iki1 BST2 PF16716.5 ETO27306.1 - 0.073 13.7 1.9 0.099 13.2 1.9 1.2 1 0 0 1 1 1 0 Bone marrow stromal antigen 2 HARP PF07443.13 ETO27307.1 - 0.06 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 HepA-related protein (HARP) HEAT PF02985.22 ETO27307.1 - 0.067 13.5 0.1 0.72 10.3 0.0 2.8 3 0 0 3 3 3 0 HEAT repeat GAS PF13851.6 ETO27309.1 - 0.0013 18.1 11.6 0.0013 18.1 11.6 3.0 1 1 2 3 3 3 1 Growth-arrest specific micro-tubule binding ComK PF06338.11 ETO27309.1 - 0.014 15.0 0.7 0.028 14.1 0.7 1.5 1 0 0 1 1 1 0 ComK protein TPR_MLP1_2 PF07926.12 ETO27309.1 - 0.15 12.1 24.2 0.13 12.3 11.5 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein TSC22 PF01166.18 ETO27309.1 - 0.32 11.4 13.7 4.6 7.6 2.0 4.3 4 0 0 4 4 4 0 TSC-22/dip/bun family CorA PF01544.18 ETO27309.1 - 1.3 8.3 6.0 3.8 6.7 6.0 1.7 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein YojJ PF10372.9 ETO27309.1 - 1.6 8.9 10.1 13 5.9 3.4 3.1 3 0 0 3 3 3 0 Bacterial membrane-spanning protein N-terminus Occludin_ELL PF07303.13 ETO27309.1 - 2.2 9.1 16.3 0.13 13.0 2.9 2.8 1 1 2 3 3 3 0 Occludin homology domain DUF3450 PF11932.8 ETO27309.1 - 3.6 6.8 18.1 4.2 6.6 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Rep_fac-A_C PF08646.10 ETO27309.1 - 8.5 6.1 13.4 34 4.1 10.1 2.5 2 1 0 2 2 2 0 Replication factor-A C terminal domain TPR_22 PF18833.1 ETO27310.1 - 0.022 14.9 0.9 0.052 13.7 0.2 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat GARP PF16731.5 ETO27310.1 - 0.028 14.1 0.2 0.041 13.6 0.2 1.3 1 1 0 1 1 1 0 Glutamic acid/alanine-rich protein of Trypanosoma Piezo_RRas_bdg PF12166.8 ETO27310.1 - 0.099 11.9 3.5 0.13 11.5 3.5 1.1 1 0 0 1 1 1 0 Piezo non-specific cation channel, R-Ras-binding domain DUF3450 PF11932.8 ETO27310.1 - 0.27 10.5 11.8 1.6 8.0 1.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Fungal_TACC PF12709.7 ETO27310.1 - 0.41 11.1 7.9 0.97 9.9 1.1 2.4 2 0 0 2 2 2 0 Fungal Transforming acidic coiled-coil (TACC) proteins PIN_8 PF18476.1 ETO27311.1 - 0.015 15.1 4.0 0.023 14.6 4.0 1.2 1 0 0 1 1 1 0 PIN like domain Ly49 PF08391.10 ETO27311.1 - 1.4 9.3 11.8 1.4 9.3 4.8 2.6 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region RnlB_antitoxin PF15933.5 ETO27312.1 - 0.0023 18.2 4.3 0.83 10.0 0.1 3.9 3 0 0 3 3 3 2 Antitoxin to bacterial toxin RNase LS or RnlA T6PP_N PF18572.1 ETO27312.1 - 3.8 7.4 11.5 0.47 10.3 1.1 3.8 4 0 0 4 4 4 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain CENP-F_leu_zip PF10473.9 ETO27312.1 - 5.5 7.0 23.4 0.42 10.6 6.5 4.3 4 1 0 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DnaJ PF00226.31 ETO27313.1 - 4.5e-22 77.9 0.5 1.4e-21 76.4 0.5 1.9 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 ETO27313.1 - 7.7e-17 61.8 1.3 3e-08 33.9 0.0 3.2 4 0 0 4 4 4 2 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO27313.1 - 9.2e-06 25.9 17.6 9.2e-06 25.9 17.6 2.6 2 1 0 2 2 2 1 DnaJ central domain Anti-TRAP PF15777.5 ETO27313.1 - 0.0058 16.6 16.0 0.17 11.9 4.9 2.7 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF3446 PF11928.8 ETO27313.1 - 0.013 15.8 2.1 0.013 15.8 2.1 3.7 4 0 0 4 4 4 0 Early growth response N-terminal domain zinc-ribbons_6 PF07191.12 ETO27313.1 - 9 6.4 15.7 2.8 8.0 5.5 2.6 1 1 1 2 2 2 0 zinc-ribbons NIF PF03031.18 ETO27314.1 - 4.4e-45 153.3 3.1 2.1e-44 151.1 1.1 2.5 2 1 0 2 2 2 1 NLI interacting factor-like phosphatase HAD PF12710.7 ETO27314.1 - 0.16 12.4 0.1 1.5 9.2 0.0 2.2 1 1 0 2 2 2 0 haloacid dehalogenase-like hydrolase DUF1424 PF07232.11 ETO27314.1 - 0.25 10.3 0.0 0.44 9.5 0.0 1.3 1 0 0 1 1 1 0 Putative rep protein (DUF1424) Acyl-CoA_dh_1 PF00441.24 ETO27315.1 - 3.5e-40 137.6 0.1 7.5e-40 136.6 0.1 1.5 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO27315.1 - 1.8e-20 72.9 0.0 3e-20 72.2 0.0 1.4 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETO27315.1 - 3.6e-19 69.4 0.2 1.1e-16 61.4 0.2 2.1 1 1 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain HpaB_N PF11794.8 ETO27315.1 - 0.023 14.4 0.8 0.18 11.5 0.1 2.3 2 1 0 2 2 2 0 4-hydroxyphenylacetate 3-hydroxylase N terminal RuvA_N PF01330.21 ETO27315.1 - 0.092 12.9 0.0 0.22 11.6 0.0 1.7 1 0 0 1 1 1 0 RuvA N terminal domain FRB_dom PF08771.11 ETO27316.1 - 0.0024 18.2 3.8 0.16 12.4 0.1 2.5 1 1 1 2 2 2 2 FKBP12-rapamycin binding domain PH PF00169.29 ETO27317.1 - 4.6e-06 27.1 3.8 4.9e-06 27.0 1.0 2.3 2 1 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO27317.1 - 0.011 16.1 5.7 0.017 15.5 3.5 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain PH_2 PF08458.10 ETO27317.1 - 0.14 12.6 0.2 0.14 12.6 0.2 2.2 1 1 1 2 2 2 0 Plant pleckstrin homology-like region DUF5102 PF17104.5 ETO27318.1 - 0.017 15.2 0.9 0.024 14.7 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5102) DUF1539 PF07560.11 ETO27318.1 - 0.27 11.3 4.8 0.39 10.8 1.3 2.2 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) bZIP_1 PF00170.21 ETO27319.1 - 0.025 14.6 2.7 0.025 14.6 2.7 5.9 1 1 5 6 6 6 0 bZIP transcription factor TPR_MLP1_2 PF07926.12 ETO27319.1 - 0.026 14.6 47.8 0.21 11.7 19.9 3.3 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein CENP-F_leu_zip PF10473.9 ETO27319.1 - 0.034 14.2 50.7 0.21 11.6 10.1 3.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 ETO27319.1 - 0.047 13.9 40.5 0.2 11.8 33.4 2.9 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Atg14 PF10186.9 ETO27319.1 - 0.068 12.2 39.7 1.3e+02 1.4 39.7 2.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 KASH_CCD PF14662.6 ETO27319.1 - 0.093 12.5 46.8 40 4.0 43.6 2.9 1 1 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH DUF16 PF01519.16 ETO27319.1 - 0.12 12.8 43.2 0.2 12.1 9.6 3.2 1 1 2 3 3 3 0 Protein of unknown function DUF16 GAS PF13851.6 ETO27319.1 - 0.13 11.6 53.7 0.092 12.1 7.1 3.0 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding Fez1 PF06818.15 ETO27319.1 - 0.2 12.1 44.9 0.13 12.7 26.0 2.0 1 1 1 2 2 2 0 Fez1 HrpB7 PF09486.10 ETO27319.1 - 0.3 11.5 13.9 1.5 9.2 7.6 2.3 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Filament PF00038.21 ETO27319.1 - 0.31 10.6 42.6 2.4 7.7 18.3 2.6 1 1 1 2 2 2 0 Intermediate filament protein HIP1_clath_bdg PF16515.5 ETO27319.1 - 0.83 10.3 39.5 0.087 13.4 3.3 3.4 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Wtap PF17098.5 ETO27319.1 - 1 9.3 30.5 0.33 10.9 16.9 3.4 1 1 1 2 2 2 0 WTAP/Mum2p family DUF3584 PF12128.8 ETO27319.1 - 1.7 6.0 38.3 2.5 5.5 38.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Mod_r PF07200.13 ETO27319.1 - 2.4 8.3 48.9 0.22 11.6 16.6 3.9 1 1 3 4 4 4 0 Modifier of rudimentary (Mod(r)) protein Tropomyosin_1 PF12718.7 ETO27319.1 - 2.7 8.1 51.7 1.9 8.7 15.1 2.6 1 1 1 2 2 2 0 Tropomyosin like ADIP PF11559.8 ETO27319.1 - 3.1 7.9 49.8 2.6 8.1 7.8 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding DUF4407 PF14362.6 ETO27319.1 - 8.1 5.7 33.3 1.7 7.9 17.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) TMF_DNA_bd PF12329.8 ETO27319.1 - 9 6.4 56.5 1 9.4 11.0 5.5 1 1 4 6 6 6 0 TATA element modulatory factor 1 DNA binding SlyX PF04102.12 ETO27319.1 - 9.8 6.9 25.0 10 6.8 5.5 4.2 2 1 3 5 5 5 0 SlyX AAA_6 PF12774.7 ETO27320.1 - 1.9e-134 447.8 0.0 1e-125 419.0 0.0 3.3 2 1 0 3 3 3 2 Hydrolytic ATP binding site of dynein motor region AAA_7 PF12775.7 ETO27320.1 - 9.4e-31 106.7 2.0 2.5e-24 85.8 0.0 4.8 6 0 0 6 6 6 3 P-loop containing dynein motor region AAA_5 PF07728.14 ETO27320.1 - 8.2e-18 64.7 0.0 4.4e-08 33.2 0.0 4.2 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 ETO27320.1 - 3.4e-13 49.8 0.5 2.4e-12 47.1 0.1 2.7 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain AAA_16 PF13191.6 ETO27320.1 - 3.7e-09 37.2 0.0 0.041 14.3 0.0 3.5 3 0 0 3 3 3 3 AAA ATPase domain AAA PF00004.29 ETO27320.1 - 2.9e-08 34.2 0.1 0.055 13.9 0.0 3.9 3 0 0 3 3 3 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO27320.1 - 1e-07 32.3 0.1 1 9.6 0.0 3.6 3 0 0 3 3 3 3 AAA domain AAA_19 PF13245.6 ETO27320.1 - 8.8e-07 29.4 0.1 0.46 10.8 0.0 4.1 4 0 0 4 4 4 2 AAA domain AAA_18 PF13238.6 ETO27320.1 - 1.9e-06 28.4 0.1 0.048 14.2 0.0 4.3 4 0 0 4 4 4 1 AAA domain RNA_helicase PF00910.22 ETO27320.1 - 3.6e-06 27.3 0.2 1.2 9.6 0.0 4.1 4 0 0 4 4 3 1 RNA helicase AAA_33 PF13671.6 ETO27320.1 - 6.9e-06 26.3 2.4 0.015 15.4 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_11 PF13086.6 ETO27320.1 - 2e-05 24.5 2.3 0.27 11.0 0.0 3.7 4 0 0 4 4 4 2 AAA domain AAA_30 PF13604.6 ETO27320.1 - 8.3e-05 22.4 0.2 3.8 7.2 0.1 3.4 3 0 0 3 3 3 1 AAA domain AAA_24 PF13479.6 ETO27320.1 - 0.00045 20.0 3.7 0.72 9.5 0.0 3.9 4 0 0 4 4 4 1 AAA domain Mg_chelatase PF01078.21 ETO27320.1 - 0.0016 17.8 0.4 0.02 14.3 0.0 2.8 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI Rad17 PF03215.15 ETO27320.1 - 0.0028 17.6 0.1 13 5.6 0.0 3.4 3 0 0 3 3 3 0 Rad17 P-loop domain NACHT PF05729.12 ETO27320.1 - 0.0037 17.2 0.2 0.85 9.5 0.0 3.6 3 0 0 3 3 3 1 NACHT domain AAA_14 PF13173.6 ETO27320.1 - 0.0039 17.2 0.0 5.5 7.0 0.0 4.0 4 0 0 4 4 3 0 AAA domain Roc PF08477.13 ETO27320.1 - 0.0067 16.6 0.6 1.3 9.2 0.1 3.6 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ETO27320.1 - 0.016 14.9 2.6 1.2 9.0 0.0 3.0 4 0 0 4 4 2 0 P-loop containing region of AAA domain TrwB_AAD_bind PF10412.9 ETO27320.1 - 0.017 14.1 0.3 5.7 5.7 0.0 3.1 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain Ras PF00071.22 ETO27320.1 - 0.024 14.2 0.1 0.13 11.8 0.1 2.2 2 0 0 2 2 2 0 Ras family AAA_28 PF13521.6 ETO27320.1 - 0.028 14.7 0.7 19 5.5 0.0 3.8 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO27320.1 - 0.05 13.0 0.3 2.9 7.2 0.0 2.5 2 0 0 2 2 2 0 FtsK/SpoIIIE family Zeta_toxin PF06414.12 ETO27320.1 - 0.051 12.8 0.1 35 3.6 0.0 3.2 3 0 0 3 3 3 0 Zeta toxin ATPase_2 PF01637.18 ETO27320.1 - 0.051 13.5 0.5 5.5 6.8 0.0 3.3 4 0 0 4 4 2 0 ATPase domain predominantly from Archaea IstB_IS21 PF01695.17 ETO27320.1 - 0.068 12.9 0.0 19 4.9 0.0 3.4 3 0 0 3 3 3 0 IstB-like ATP binding protein DUF5040 PF16443.5 ETO27320.1 - 0.084 12.3 0.1 0.2 11.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF5040) TniB PF05621.11 ETO27320.1 - 0.084 12.3 0.0 1.8 7.9 0.0 2.7 2 0 0 2 2 2 0 Bacterial TniB protein PRK PF00485.18 ETO27320.1 - 0.14 11.8 0.9 0.74 9.5 0.1 2.5 3 0 0 3 3 2 0 Phosphoribulokinase / Uridine kinase family PhoH PF02562.16 ETO27320.1 - 0.16 11.4 2.5 8.5 5.8 0.0 3.4 4 0 0 4 4 3 0 PhoH-like protein DUF853 PF05872.12 ETO27320.1 - 0.17 10.4 1.7 24 3.3 0.0 3.2 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF853) UvrD-helicase PF00580.21 ETO27320.1 - 0.29 10.6 0.0 0.29 10.6 0.0 2.5 3 0 0 3 3 3 0 UvrD/REP helicase N-terminal domain DUF2075 PF09848.9 ETO27320.1 - 0.3 10.3 1.7 0.86 8.8 0.0 2.3 3 0 0 3 3 2 0 Uncharacterized conserved protein (DUF2075) AAA_17 PF13207.6 ETO27320.1 - 0.35 11.3 1.6 42 4.6 0.0 3.4 3 0 0 3 3 3 0 AAA domain ATP_bind_1 PF03029.17 ETO27320.1 - 8.1 6.1 7.3 9 6.0 0.0 3.8 4 0 0 4 4 4 0 Conserved hypothetical ATP binding protein DUF1284 PF06935.11 ETO27321.1 - 0.23 11.9 6.1 1 9.9 0.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) Lys-AminoMut_A PF09043.11 ETO27322.1 - 2 6.8 7.8 1.8 6.9 6.8 1.4 1 1 0 1 1 1 0 D-Lysine 5,6-aminomutase TIM-barrel domain of alpha subunit DUF4407 PF14362.6 ETO27322.1 - 2 7.7 21.7 2.6 7.3 21.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3584 PF12128.8 ETO27322.1 - 3.5 5.0 32.8 4.3 4.7 32.8 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) WDCP PF15390.6 ETO27322.1 - 6 5.1 15.7 6.9 4.9 15.7 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family PepSY_2 PF13670.6 ETO27323.1 - 0.54 10.3 7.6 0.14 12.2 3.4 2.0 2 0 0 2 2 2 0 Peptidase propeptide and YPEB domain Macoilin PF09726.9 ETO27323.1 - 6.9 5.1 21.0 8.3 4.8 21.0 1.2 1 0 0 1 1 1 0 Macoilin family TPR_14 PF13428.6 ETO27324.1 - 2.8e-32 108.6 23.4 0.0048 17.6 0.3 13.6 5 4 9 14 14 14 9 Tetratricopeptide repeat TPR_19 PF14559.6 ETO27324.1 - 3.2e-24 85.2 4.1 7.1e-06 26.4 0.0 8.8 6 3 3 9 9 9 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27324.1 - 3.7e-10 39.1 7.5 3.3 8.0 0.0 10.0 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO27324.1 - 5e-08 33.0 7.6 0.13 12.4 0.5 5.8 5 1 1 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27324.1 - 2.1e-06 27.5 1.3 62 4.2 0.0 8.2 9 0 0 9 9 9 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27324.1 - 3.9e-06 26.8 3.2 1.9 9.0 0.0 8.9 10 1 1 12 12 10 1 Tetratricopeptide repeat Suf PF05843.14 ETO27324.1 - 9.7e-06 25.8 0.0 1.2 9.1 0.0 4.5 5 0 0 5 5 5 1 Suppressor of forked protein (Suf) TPR_6 PF13174.6 ETO27324.1 - 0.00073 20.0 4.2 1.7e+02 3.1 0.0 7.8 8 0 0 8 8 8 0 Tetratricopeptide repeat Mad3_BUB1_I PF08311.12 ETO27324.1 - 0.079 12.9 4.7 41 4.2 0.0 5.3 5 1 1 6 6 6 0 Mad3/BUB1 homology region 1 TPR_12 PF13424.6 ETO27324.1 - 0.39 11.1 11.2 0.81 10.0 0.1 6.2 9 0 0 9 9 9 0 Tetratricopeptide repeat DHR10 PF18595.1 ETO27324.1 - 0.66 10.1 3.8 11 6.1 0.6 3.9 3 0 0 3 3 3 0 Designed helical repeat protein 10 domain Aminotran_3 PF00202.21 ETO27325.1 - 0.0015 17.2 0.0 0.0018 17.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Peptidase_S49 PF01343.18 ETO27326.1 - 9e-31 106.9 0.0 1.4e-30 106.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family S49 PUB PF09409.10 ETO27328.1 - 0.0033 17.3 0.9 0.044 13.7 0.2 2.8 2 0 0 2 2 2 1 PUB domain AAR2 PF05282.11 ETO27330.1 - 1.2e-62 212.4 10.2 2.6e-62 211.3 10.2 1.6 1 1 0 1 1 1 1 AAR2 protein CDC45 PF02724.14 ETO27330.1 - 0.76 8.0 11.3 1.2 7.3 11.3 1.3 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO27330.1 - 1.5 7.5 6.3 2.3 6.9 6.3 1.4 1 0 0 1 1 1 0 Presenilin PI_PP_I PF18363.1 ETO27332.1 - 0.00055 20.1 3.0 0.00055 20.1 3.0 2.7 2 1 0 2 2 2 1 Phosphoinositide phosphatase insertion domain Spc7 PF08317.11 ETO27332.1 - 0.57 9.0 39.3 1.7 7.5 21.9 2.2 2 0 0 2 2 2 0 Spc7 kinetochore protein End3 PF12761.7 ETO27332.1 - 7.3 6.7 31.2 4.4 7.4 5.7 2.2 2 0 0 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Rubis-subs-bind PF09273.11 ETO27333.1 - 6.1e-15 56.0 0.0 1.1e-14 55.2 0.0 1.4 1 0 0 1 1 1 1 Rubisco LSMT substrate-binding SET PF00856.28 ETO27333.1 - 3.7e-06 27.4 0.0 1.1e-05 25.9 0.0 1.7 2 0 0 2 2 2 1 SET domain TPR_1 PF00515.28 ETO27334.1 - 1.3e-07 31.1 2.7 0.0093 15.8 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27334.1 - 3.4e-07 29.9 1.3 0.02 15.0 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27334.1 - 3.9e-05 23.5 1.7 0.17 12.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27334.1 - 5.8e-05 22.8 0.5 0.13 12.2 0.3 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO27334.1 - 0.0011 19.2 0.9 0.3 11.4 0.6 2.5 2 1 1 3 3 3 2 Tetratricopeptide repeat FXMRP1_C_core PF12235.8 ETO27334.1 - 0.069 13.8 5.2 0.11 13.2 5.2 1.3 1 0 0 1 1 1 0 Fragile X-related 1 protein core C terminal PP_kinase_N PF13089.6 ETO27334.1 - 0.31 11.4 3.5 0.96 9.8 0.0 2.3 2 1 0 2 2 2 0 Polyphosphate kinase N-terminal domain AAA_13 PF13166.6 ETO27335.1 - 2.7e-06 26.4 43.5 2.7e-06 26.4 43.5 3.1 1 1 2 3 3 2 1 AAA domain GAS PF13851.6 ETO27335.1 - 0.00045 19.6 17.6 0.00045 19.6 17.6 4.8 2 2 2 4 4 4 1 Growth-arrest specific micro-tubule binding bZIP_1 PF00170.21 ETO27335.1 - 0.0026 17.8 12.6 0.01 15.9 1.2 10.1 5 2 5 10 10 9 2 bZIP transcription factor Uso1_p115_C PF04871.13 ETO27335.1 - 0.0079 16.6 9.6 0.0079 16.6 9.6 6.4 2 2 3 5 5 4 1 Uso1 / p115 like vesicle tethering protein, C terminal region Tropomyosin_1 PF12718.7 ETO27335.1 - 0.018 15.2 14.8 0.018 15.2 14.8 5.3 2 1 3 5 5 5 0 Tropomyosin like Seryl_tRNA_N PF02403.22 ETO27335.1 - 0.023 14.9 9.5 0.023 14.9 9.5 6.7 2 2 4 6 6 5 0 Seryl-tRNA synthetase N-terminal domain bZIP_2 PF07716.15 ETO27335.1 - 0.055 13.6 0.7 0.055 13.6 0.7 11.0 6 4 5 12 12 12 0 Basic region leucine zipper HMMR_N PF15905.5 ETO27335.1 - 2 7.8 106.8 1.1 8.6 68.2 3.5 1 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal DUF3452 PF11934.8 ETO27335.1 - 2 7.9 22.8 2.4 7.7 1.0 4.6 2 2 2 4 4 4 0 Domain of unknown function (DUF3452) Spc7 PF08317.11 ETO27335.1 - 2.1 7.1 101.2 0.75 8.6 48.3 4.9 2 1 2 4 4 4 0 Spc7 kinetochore protein Feld-I_B PF09252.10 ETO27335.1 - 3.1 7.8 8.5 34 4.5 4.0 3.1 2 0 0 2 2 2 0 Allergen Fel d I-B chain FUSC PF04632.12 ETO27335.1 - 3.3 6.1 12.4 0.69 8.4 8.2 1.9 2 1 0 2 2 2 0 Fusaric acid resistance protein family DUF948 PF06103.11 ETO27335.1 - 3.8 7.8 36.1 0.55 10.5 4.0 6.4 3 1 2 5 5 5 0 Bacterial protein of unknown function (DUF948) DUF812 PF05667.11 ETO27335.1 - 7.5 5.3 95.4 0.12 11.2 16.1 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF812) Methyltransf_31 PF13847.6 ETO27336.1 - 0.007 16.2 1.2 0.007 16.2 1.2 2.1 2 1 0 2 2 2 1 Methyltransferase domain TRAF_BIRC3_bd PF16673.5 ETO27336.1 - 0.2 11.5 0.1 0.2 11.5 0.1 6.9 4 4 3 8 8 8 0 TNF receptor-associated factor BIRC3 binding domain ATG16 PF08614.11 ETO27336.1 - 0.41 10.8 52.6 1.7 8.8 14.7 4.4 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) PKcGMP_CC PF16808.5 ETO27336.1 - 0.49 10.3 51.7 0.46 10.4 3.1 7.6 6 2 1 7 7 7 0 Coiled-coil N-terminus of cGMP-dependent protein kinase Lebercilin PF15619.6 ETO27336.1 - 0.77 9.4 65.1 0.45 10.1 13.2 3.5 2 2 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF948 PF06103.11 ETO27336.1 - 0.86 9.9 20.0 0.36 11.1 1.7 3.9 3 1 1 4 4 4 0 Bacterial protein of unknown function (DUF948) HMMR_N PF15905.5 ETO27336.1 - 0.94 8.9 64.7 3.6 7.0 17.8 3.8 1 1 4 5 5 5 0 Hyaluronan mediated motility receptor N-terminal Cas6b_C PF17262.2 ETO27336.1 - 2.2 8.4 10.4 1.6 8.9 3.0 2.8 2 0 0 2 2 2 0 Cas6b C-terminal domain BLOC1_2 PF10046.9 ETO27336.1 - 4.1 7.8 43.6 0.045 14.1 7.3 4.6 3 1 1 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Ntox16 PF15523.6 ETO27336.1 - 4.3 7.6 12.4 0.18 12.1 4.4 2.8 2 1 0 2 2 2 0 Novel toxin 16 Fez1 PF06818.15 ETO27336.1 - 4.7 7.6 52.0 0.79 10.1 15.4 3.3 1 1 2 3 3 2 0 Fez1 DUF99 PF01949.16 ETO27336.1 - 5.8 6.3 9.2 7.7 5.9 1.4 2.9 2 2 1 3 3 3 0 Protein of unknown function DUF99 T3SSipB PF16535.5 ETO27336.1 - 6.4 7.2 21.9 67 3.9 16.2 3.2 1 1 1 2 2 2 0 Type III cell invasion protein SipB ADIP PF11559.8 ETO27336.1 - 9.7 6.3 50.1 0.48 10.5 6.5 5.1 1 1 3 4 4 4 0 Afadin- and alpha -actinin-Binding RhoGAP PF00620.27 ETO27337.1 - 1.2e-18 67.4 0.5 2.5e-18 66.4 0.1 1.7 2 0 0 2 2 2 1 RhoGAP domain PH PF00169.29 ETO27337.1 - 1.9e-06 28.3 0.5 6e-06 26.7 0.1 2.0 2 0 0 2 2 2 1 PH domain CbiG_mid PF11761.8 ETO27339.1 - 0.12 12.5 0.0 0.19 11.9 0.0 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis central region Sec7_N PF12783.7 ETO27341.1 - 3.6e-28 98.4 0.2 3.6e-28 98.4 0.2 2.4 2 0 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal DCB PF16213.5 ETO27341.1 - 1.4e-09 37.8 6.5 3.8e-09 36.4 0.3 3.3 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 DUF2207 PF09972.9 ETO27341.1 - 1.8 7.2 5.5 5.9 5.5 5.5 1.8 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) SAM_1 PF00536.30 ETO27342.1 - 4.4e-15 55.9 0.1 6.7e-15 55.3 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO27342.1 - 8.4e-14 51.4 0.1 1.4e-13 50.7 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_4 PF18017.1 ETO27342.1 - 4.1e-08 33.1 0.0 7.3e-08 32.3 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO27342.1 - 0.031 14.2 0.0 0.056 13.4 0.0 1.5 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Epimerase PF01370.21 ETO27343.1 - 7.1e-17 61.7 0.0 2.3e-16 60.0 0.0 1.7 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO27343.1 - 2.7e-08 33.6 0.0 1.5e-07 31.2 0.0 1.9 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase RmlD_sub_bind PF04321.17 ETO27343.1 - 3.6e-08 32.9 0.0 5.6e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 RmlD substrate binding domain NAD_binding_4 PF07993.12 ETO27343.1 - 0.00025 20.3 0.0 0.0038 16.4 0.0 2.6 2 1 0 2 2 2 1 Male sterility protein 3Beta_HSD PF01073.19 ETO27343.1 - 0.0024 16.9 0.0 0.0092 15.0 0.0 1.9 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETO27343.1 - 0.019 14.9 0.0 0.03 14.2 0.0 1.3 1 0 0 1 1 1 0 NAD(P)H-binding Polysacc_synt_2 PF02719.15 ETO27343.1 - 0.019 14.1 0.5 0.042 13.0 0.5 1.5 1 1 0 1 1 1 0 Polysaccharide biosynthesis protein DapB_N PF01113.20 ETO27343.1 - 0.082 13.0 0.0 0.15 12.2 0.0 1.5 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Arm PF00514.23 ETO27344.1 - 9.7e-20 69.9 11.9 2.4e-06 27.4 0.2 7.3 6 1 1 7 7 7 4 Armadillo/beta-catenin-like repeat HEAT_2 PF13646.6 ETO27344.1 - 2.5e-10 40.6 3.6 9.6e-05 22.7 0.1 4.1 3 1 0 4 4 4 2 HEAT repeats HEAT PF02985.22 ETO27344.1 - 1.2e-09 37.6 0.3 0.091 13.1 0.0 4.9 4 0 0 4 4 4 3 HEAT repeat Adaptin_N PF01602.20 ETO27344.1 - 7.1e-05 21.6 7.2 0.0039 15.8 1.5 2.7 3 0 0 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 ETO27344.1 - 0.00028 21.0 4.8 0.0045 17.0 0.3 3.8 3 1 2 5 5 5 1 non-SMC mitotic condensation complex subunit 1 DNA_alkylation PF08713.11 ETO27344.1 - 0.00066 19.5 0.4 2.1 8.0 0.0 3.1 2 1 1 3 3 3 2 DNA alkylation repair enzyme CHASE6_C PF17150.4 ETO27344.1 - 0.00079 20.1 1.1 0.44 11.3 0.1 3.9 3 1 1 4 4 4 1 C-terminal domain of two-partite extracellular sensor domain Proteasom_PSMB PF10508.9 ETO27344.1 - 0.00092 17.8 1.4 0.00092 17.8 1.4 2.5 3 0 0 3 3 3 1 Proteasome non-ATPase 26S subunit V-ATPase_H_C PF11698.8 ETO27344.1 - 0.0017 18.4 1.3 1.2 9.3 0.1 3.0 2 1 1 3 3 3 3 V-ATPase subunit H HEAT_EZ PF13513.6 ETO27344.1 - 0.0033 17.9 6.2 2.6 8.6 0.0 4.8 4 2 1 5 5 5 1 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO27344.1 - 0.0083 16.7 0.2 0.055 14.1 0.1 2.4 1 1 1 2 2 2 1 Vacuolar 14 Fab1-binding region DUF3361 PF11841.8 ETO27344.1 - 0.064 13.2 6.6 1.8 8.5 0.4 3.1 3 1 1 4 4 4 0 Domain of unknown function (DUF3361) RICTOR_N PF14664.6 ETO27344.1 - 0.066 12.2 4.1 0.46 9.4 0.3 3.1 3 1 1 4 4 4 0 Rapamycin-insensitive companion of mTOR, N-term HEAT_PBS PF03130.16 ETO27344.1 - 0.081 13.6 3.7 19 6.3 0.1 4.4 4 0 0 4 4 3 0 PBS lyase HEAT-like repeat Vps5 PF09325.10 ETO27344.1 - 0.9 9.0 3.7 2.4 7.6 0.7 2.5 2 1 0 2 2 2 0 Vps5 C terminal like WD40 PF00400.32 ETO27345.1 - 1.6e-31 107.8 17.8 1.8e-05 25.4 0.8 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27345.1 - 2.6e-09 37.3 0.9 0.16 12.3 0.0 5.7 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27345.1 - 3e-08 32.8 4.5 0.055 12.1 0.0 5.0 2 2 3 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO27345.1 - 9.3e-05 22.4 1.9 0.24 11.5 0.1 4.0 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region Ricin_B_lectin PF00652.22 ETO27345.1 - 0.31 11.3 7.6 0.56 10.5 1.5 3.1 1 1 1 3 3 3 0 Ricin-type beta-trefoil lectin domain WD40 PF00400.32 ETO27346.1 - 5.6e-73 239.0 22.1 2e-11 44.2 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27346.1 - 2.8e-21 75.6 4.8 0.0016 18.7 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27346.1 - 4.4e-12 45.6 0.6 0.16 10.9 0.0 6.3 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO27346.1 - 1.6e-09 37.0 4.1 0.16 10.6 0.0 6.0 2 1 2 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO27346.1 - 6.2e-07 29.0 2.5 0.012 14.9 0.2 3.8 1 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO27346.1 - 1.5e-05 23.7 0.9 0.017 13.7 0.0 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain BBS2_Mid PF14783.6 ETO27346.1 - 0.00023 21.2 3.3 7.4 6.7 0.2 5.3 2 2 3 5 5 5 2 Ciliary BBSome complex subunit 2, middle region MRJP PF03022.16 ETO27346.1 - 0.028 13.8 0.0 0.058 12.7 0.0 1.5 1 0 0 1 1 1 0 Major royal jelly protein Phage_CI_repr PF07022.13 ETO27346.1 - 0.14 12.3 0.0 10 6.3 0.0 2.7 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain Proteasome_A_N PF10584.9 ETO27346.1 - 0.14 11.9 0.7 12 5.6 0.0 3.2 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PD40 PF07676.12 ETO27346.1 - 0.88 9.6 7.6 88 3.2 0.0 5.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF3671 PF12420.8 ETO27347.1 - 0.41 10.7 6.6 0.72 10.0 6.1 1.7 2 0 0 2 2 2 0 Protein of unknown function SAGA-Tad1 PF12767.7 ETO27349.1 - 1.3e-13 51.3 13.8 1.3e-13 51.3 13.8 2.9 2 1 1 3 3 3 1 Transcriptional regulator of RNA polII, SAGA, subunit ubiquitin PF00240.23 ETO27351.1 - 0.00013 21.6 0.2 0.00029 20.5 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin family TBK1_ULD PF18396.1 ETO27351.1 - 0.00076 19.4 0.0 0.0012 18.7 0.0 1.3 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain Rad60-SLD PF11976.8 ETO27351.1 - 0.15 11.9 0.3 0.45 10.4 0.1 1.8 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like Torus PF16131.5 ETO27351.1 - 0.54 11.0 3.4 0.85 10.3 3.3 1.4 1 1 0 1 1 1 0 Torus domain GGACT PF06094.12 ETO27352.1 - 4.8e-05 24.0 0.0 0.00066 20.3 0.0 2.1 1 1 1 2 2 2 1 Gamma-glutamyl cyclotransferase, AIG2-like Pex14_N PF04695.13 ETO27353.1 - 9.6e-05 23.1 6.5 9.6e-05 23.1 6.5 1.8 2 0 0 2 2 2 1 Peroxisomal membrane anchor protein (Pex14p) conserved region PUB PF09409.10 ETO27354.1 - 2.7e-06 27.2 0.0 4.6e-06 26.5 0.0 1.4 1 0 0 1 1 1 1 PUB domain Drf_GBD PF06371.13 ETO27354.1 - 0.0047 16.5 0.0 0.01 15.4 0.0 1.6 2 0 0 2 2 2 1 Diaphanous GTPase-binding Domain Methyltransf_18 PF12847.7 ETO27355.1 - 0.055 13.4 0.2 0.17 11.8 0.0 1.8 1 1 1 2 2 2 0 Methyltransferase domain DUF4763 PF15960.5 ETO27356.1 - 0.0042 16.4 0.7 0.02 14.2 0.1 1.9 2 0 0 2 2 2 1 Domain of unknown function (DUF4763) TPR_MLP1_2 PF07926.12 ETO27356.1 - 0.048 13.7 3.3 0.27 11.3 0.2 2.7 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein SKA2 PF16740.5 ETO27356.1 - 0.16 11.7 3.0 1.7 8.5 0.1 3.0 3 1 0 3 3 3 0 Spindle and kinetochore-associated protein 2 CENP-F_leu_zip PF10473.9 ETO27356.1 - 0.69 9.9 8.8 2.2 8.3 1.0 2.8 2 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MHYT PF03707.16 ETO27357.1 - 2.4e-37 126.9 15.6 1.9e-14 53.6 2.8 4.2 4 0 0 4 4 4 4 Bacterial signalling protein N terminal repeat PCC_BT PF18140.1 ETO27357.1 - 0.089 13.1 0.1 0.14 12.5 0.1 1.4 1 0 0 1 1 1 0 Propionyl-coenzyme A carboxylase BT domain BSMAP PF12280.8 ETO27357.1 - 0.22 11.7 0.6 0.42 10.8 0.6 1.4 1 0 0 1 1 1 0 Brain specific membrane anchored protein Holin_9 PF16936.5 ETO27357.1 - 9.4 6.5 12.4 1.3 9.2 6.4 2.4 2 1 0 2 2 2 0 Putative holin PBP1_TM PF14812.6 ETO27358.1 - 0.12 12.7 0.8 0.26 11.7 0.8 1.5 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pox_Ag35 PF03286.14 ETO27358.1 - 0.7 9.7 6.2 0.063 13.1 0.6 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein UNC45-central PF11701.8 ETO27359.1 - 0.019 14.9 0.4 0.045 13.7 0.4 1.7 1 0 0 1 1 1 0 Myosin-binding striated muscle assembly central PBP1_TM PF14812.6 ETO27359.1 - 0.14 12.6 7.5 0.51 10.7 3.1 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF5582 PF17819.1 ETO27359.1 - 9 6.7 11.2 0.42 11.1 0.4 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5582) UQ_con PF00179.26 ETO27360.1 - 0.00015 21.4 0.9 0.0015 18.2 0.9 2.2 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO27360.1 - 0.04 13.6 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Prokaryotic E2 family B Takusan PF04822.13 ETO27362.1 - 0.027 14.3 4.5 0.077 12.9 4.5 1.8 1 0 0 1 1 1 0 Takusan EST1 PF10374.9 ETO27362.1 - 0.039 14.6 5.1 0.059 14.0 2.7 2.4 2 0 0 2 2 2 0 Telomerase activating protein Est1 NAD_binding_9 PF13454.6 ETO27365.1 - 0.0046 16.9 0.0 0.0087 16.1 0.0 1.5 1 1 1 2 2 2 1 FAD-NAD(P)-binding Malic_M PF03949.15 ETO27365.1 - 0.043 13.1 0.7 0.11 11.8 0.7 1.6 1 1 0 1 1 1 0 Malic enzyme, NAD binding domain Pyr_redox_2 PF07992.14 ETO27365.1 - 0.085 12.1 1.7 0.12 11.6 1.7 1.3 1 1 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_8 PF13450.6 ETO27365.1 - 0.09 13.0 0.0 0.14 12.4 0.0 1.3 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain DAO PF01266.24 ETO27365.1 - 0.1 12.2 0.1 0.15 11.6 0.1 1.2 1 0 0 1 1 1 0 FAD dependent oxidoreductase GIDA PF01134.22 ETO27365.1 - 0.15 11.1 1.8 2 7.4 0.3 2.1 2 0 0 2 2 2 0 Glucose inhibited division protein A Pyr_redox_2 PF07992.14 ETO27366.1 - 0.02 14.1 0.0 0.027 13.7 0.0 1.1 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO27367.1 - 2.2e-12 46.8 0.0 3.9e-12 46.0 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Rubredoxin_C PF18267.1 ETO27367.1 - 0.039 13.9 0.0 0.14 12.1 0.0 2.1 2 0 0 2 2 2 0 Rubredoxin NAD+ reductase C-terminal domain Annexin PF00191.20 ETO27368.1 - 1.3e-12 47.6 0.1 2.1e-12 46.9 0.1 1.3 1 0 0 1 1 1 1 Annexin Ribosomal_60s PF00428.19 ETO27368.1 - 0.015 15.9 2.7 0.036 14.7 2.9 1.5 2 0 0 2 2 2 0 60s Acidic ribosomal protein Rot1 PF10681.9 ETO27368.1 - 0.033 13.7 0.1 0.037 13.5 0.1 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal DUF3824 PF12868.7 ETO27368.1 - 0.11 13.1 0.2 0.13 12.9 0.2 1.1 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) Anoctamin PF04547.12 ETO27369.1 - 0.00057 18.8 1.3 0.00071 18.5 1.3 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel DUF3539 PF12058.8 ETO27369.1 - 0.038 14.1 0.3 0.081 13.1 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3539) Orf78 PF06024.12 ETO27369.1 - 0.18 12.1 5.0 3.7 7.9 0.4 2.3 2 0 0 2 2 2 0 Orf78 (ac78) LMBR1 PF04791.16 ETO27370.1 - 1.5e-16 60.5 2.2 2.9e-16 59.5 2.2 1.5 1 1 0 1 1 1 1 LMBR1-like membrane protein GAS PF13851.6 ETO27370.1 - 0.021 14.2 1.2 0.03 13.7 1.2 1.2 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding PH PF00169.29 ETO27371.1 - 0.00082 19.9 0.2 0.042 14.4 0.1 2.4 2 1 0 2 2 2 1 PH domain Neogenin_C PF06583.12 ETO27371.1 - 0.039 13.8 0.3 3.9 7.2 0.0 2.1 2 0 0 2 2 2 0 Neogenin C-terminus WD40 PF00400.32 ETO27372.1 - 1.6e-63 209.1 19.4 3.8e-10 40.2 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27372.1 - 4.1e-25 87.9 0.3 3.4e-06 27.3 0.0 6.5 1 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27372.1 - 1.5e-22 80.0 0.0 0.00055 19.0 0.0 6.8 2 1 5 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO27372.1 - 3.5e-13 49.9 0.3 6.6e-05 22.9 0.0 3.7 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETO27372.1 - 1.5e-09 37.2 5.1 0.0048 15.7 0.2 5.1 2 1 4 6 6 6 3 Nup133 N terminal like PD40 PF07676.12 ETO27372.1 - 5e-09 35.9 4.3 1.8 8.6 0.0 5.9 6 0 0 6 6 5 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO27372.1 - 1.7e-08 33.6 2.4 0.11 11.1 0.0 5.7 3 1 2 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO27372.1 - 1.4e-07 31.1 0.0 0.09 12.1 0.0 3.2 1 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO27372.1 - 8.2e-06 24.6 0.0 0.016 13.8 0.0 2.9 2 1 1 3 3 3 2 Cytochrome D1 heme domain Frtz PF11768.8 ETO27372.1 - 8.6e-05 21.0 0.0 0.52 8.5 0.0 2.9 1 1 3 4 4 4 3 WD repeat-containing and planar cell polarity effector protein Fritz DUF5570 PF17731.1 ETO27372.1 - 0.00024 21.2 0.4 1.6 8.9 0.0 4.5 1 1 4 5 5 5 1 Family of unknown function (DUF5570) DUF4875 PF16175.5 ETO27372.1 - 0.013 15.6 0.0 2 8.6 0.0 3.3 2 1 2 4 4 4 0 Domain of unknown function (DUF4875) nos_propeller PF18764.1 ETO27372.1 - 0.023 14.6 0.0 37 4.3 0.0 4.1 4 1 1 5 5 5 0 Nitrous oxide reductase propeller repeat Proteasome_A_N PF10584.9 ETO27372.1 - 0.043 13.5 5.9 24 4.7 0.1 4.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature SBD PF17882.1 ETO27372.1 - 0.13 12.1 0.9 41 4.0 0.0 4.1 2 1 3 5 5 5 0 OAA-family lectin sugar binding domain Med21 PF11221.8 ETO27373.1 - 0.11 12.7 8.9 0.29 11.4 1.8 2.4 2 1 0 2 2 2 0 Subunit 21 of Mediator complex RICTOR_N PF14664.6 ETO27373.1 - 1.8 7.4 8.4 0.62 9.0 3.6 2.1 1 1 2 3 3 3 0 Rapamycin-insensitive companion of mTOR, N-term zf-CCHC_2 PF13696.6 ETO27375.1 - 3.9e-11 42.6 6.8 8.4e-11 41.5 6.8 1.6 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ETO27375.1 - 6.2e-05 22.9 1.9 0.00011 22.1 1.9 1.4 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC_3 PF13917.6 ETO27375.1 - 0.026 14.5 0.2 0.066 13.2 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle Ank_2 PF12796.7 ETO27376.1 - 4.8e-09 36.7 1.5 0.002 18.7 0.1 2.4 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO27376.1 - 3.3e-06 27.5 0.6 0.003 18.1 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO27376.1 - 5.5e-06 26.3 1.1 1.7 9.4 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ETO27376.1 - 0.074 13.5 1.6 23 5.6 0.1 3.7 4 0 0 4 4 4 0 Ankyrin repeat DUF4119 PF13494.6 ETO27376.1 - 0.077 13.1 1.4 1.9 8.7 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function, B. Theta Gene description (DUF4119) DsrD PF08679.11 ETO27376.1 - 0.13 12.5 0.0 0.13 12.5 0.0 2.2 2 1 1 3 3 3 0 Dissimilatory sulfite reductase D (DsrD) Ank_5 PF13857.6 ETO27376.1 - 0.14 12.5 0.9 5.2 7.5 0.2 2.5 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Mac-1 PF09028.10 ETO27376.1 - 0.55 9.2 5.8 1 8.4 2.4 2.1 1 1 1 2 2 2 0 Mac 1 LRS4 PF10422.9 ETO27376.1 - 2.4 7.7 6.3 1.6 8.3 2.6 2.0 2 0 0 2 2 2 0 Monopolin complex subunit LRS4 DUF1428 PF07237.11 ETO27377.1 - 0.014 15.7 1.3 0.03 14.6 1.3 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF1428) RNA_pol_Rpc4 PF05132.14 ETO27377.1 - 0.027 14.9 13.9 0.046 14.1 5.1 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 V_ATPase_I PF01496.19 ETO27377.1 - 0.45 8.4 23.9 0.13 10.2 6.3 2.1 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family MA3 PF02847.17 ETO27378.1 - 2.9e-19 69.1 4.6 6.6e-19 68.0 2.6 2.3 2 0 0 2 2 2 1 MA3 domain FliD_N PF02465.18 ETO27378.1 - 0.38 11.5 2.9 33 5.2 1.5 2.4 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus MIF4G PF02854.19 ETO27379.1 - 4.6e-05 23.1 0.1 8.1e-05 22.3 0.1 1.4 1 0 0 1 1 1 1 MIF4G domain TrmE_N PF10396.9 ETO27379.1 - 0.0011 19.2 0.0 0.0024 18.2 0.0 1.4 1 0 0 1 1 1 1 GTP-binding protein TrmE N-terminus Shadoo PF14999.6 ETO27379.1 - 0.0054 16.8 1.8 0.011 15.9 1.8 1.5 1 0 0 1 1 1 1 Shadow of prion protein, neuroprotective zf-C2H2_jaz PF12171.8 ETO27379.1 - 0.14 12.5 0.2 0.28 11.5 0.2 1.5 1 0 0 1 1 1 0 Zinc-finger double-stranded RNA-binding WD40 PF00400.32 ETO27380.1 - 2.3e-62 205.4 24.6 2.2e-10 41.0 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27380.1 - 1.1e-18 67.3 1.6 0.0019 18.4 0.0 6.2 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27380.1 - 1.4e-15 57.1 1.9 0.17 10.8 0.0 6.9 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO27380.1 - 6e-08 31.8 1.7 0.00063 18.5 0.1 4.2 3 1 1 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO27380.1 - 2.8e-05 23.6 0.1 0.9 8.8 0.0 3.4 2 1 3 5 5 5 3 WD40-like domain PD40 PF07676.12 ETO27380.1 - 4.7e-05 23.2 4.8 9.2 6.3 0.1 5.7 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO27380.1 - 0.0015 17.6 0.9 2.3 7.1 0.0 4.2 2 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO27380.1 - 0.0021 16.7 0.5 1.1 7.7 0.0 3.4 1 1 3 4 4 4 2 Cytochrome D1 heme domain SBD PF17882.1 ETO27380.1 - 0.02 14.7 0.5 24 4.8 0.0 3.9 1 1 2 4 4 4 0 OAA-family lectin sugar binding domain HARP PF07443.13 ETO27380.1 - 0.024 14.3 0.0 11 5.8 0.0 3.3 3 0 0 3 3 3 0 HepA-related protein (HARP) WD40 PF00400.32 ETO27381.1 - 2.9e-33 113.3 19.3 2.6e-06 28.0 0.1 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27381.1 - 1.1e-12 48.1 2.0 0.038 14.3 0.0 5.9 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27381.1 - 6.1e-08 31.8 5.0 0.006 15.3 0.3 4.2 1 1 1 3 3 3 3 Nucleoporin Nup120/160 PRA1 PF03208.19 ETO27381.1 - 0.19 11.4 3.1 0.31 10.7 3.1 1.2 1 0 0 1 1 1 0 PRA1 family protein MIP PF00230.20 ETO27383.1 - 5.3e-24 85.2 6.4 6.8e-24 84.8 6.4 1.1 1 0 0 1 1 1 1 Major intrinsic protein Heliorhodopsin PF18761.1 ETO27383.1 - 0.24 10.7 6.8 0.43 9.9 1.7 2.3 1 1 1 2 2 2 0 Heliorhodopsin Melibiase_C PF17801.1 ETO27384.1 - 9.7e-16 57.6 0.3 1.9e-15 56.7 0.3 1.5 1 0 0 1 1 1 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase_2_C PF17450.2 ETO27384.1 - 2.6e-06 27.5 0.0 9.3e-06 25.8 0.0 1.9 1 0 0 1 1 1 1 Alpha galactosidase A C-terminal beta sandwich domain Melibiase_2 PF16499.5 ETO27384.1 - 0.031 13.5 0.8 0.04 13.1 0.0 1.5 2 0 0 2 2 2 0 Alpha galactosidase A rpo30_N PF12410.8 ETO27385.1 - 0.058 13.3 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 Poxvirus DNA dependent RNA polymerase 30kDa subunit FRG PF08867.11 ETO27385.1 - 0.33 11.9 5.8 0.62 11.1 1.6 2.6 2 1 0 2 2 2 0 FRG domain CAP_N PF01213.19 ETO27386.1 - 0.0072 15.8 2.2 0.017 14.6 2.2 1.6 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Mito_fiss_reg PF05308.11 ETO27386.1 - 0.02 15.0 2.3 0.053 13.6 2.3 1.7 1 0 0 1 1 1 0 Mitochondrial fission regulator DUF2796 PF10986.8 ETO27386.1 - 0.037 14.0 2.7 0.068 13.1 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) PRIMA1 PF16101.5 ETO27386.1 - 0.37 10.8 7.1 0.88 9.6 7.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 NOA36 PF06524.12 ETO27386.1 - 1.8 7.8 13.2 3.1 7.0 13.2 1.3 1 0 0 1 1 1 0 NOA36 protein T4SS PF07996.11 ETO27387.1 - 0.15 12.4 0.0 0.36 11.2 0.0 1.5 1 0 0 1 1 1 0 Type IV secretion system proteins CLN3 PF02487.17 ETO27389.1 - 0.16 11.0 0.6 0.2 10.7 0.6 1.1 1 0 0 1 1 1 0 CLN3 protein NPR3 PF03666.13 ETO27389.1 - 0.67 8.7 8.0 0.71 8.6 8.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO27389.1 - 1 8.1 6.1 1.2 7.8 6.1 1.0 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 ETO27389.1 - 1.1 7.6 3.8 1.1 7.6 3.8 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Menin PF05053.13 ETO27389.1 - 5.8 5.1 11.2 6.8 4.9 11.2 1.1 1 0 0 1 1 1 0 Menin Piwi PF02171.17 ETO27390.1 - 3.4e-10 39.7 0.0 3.4e-09 36.4 0.0 2.1 1 1 0 1 1 1 1 Piwi domain WD40 PF00400.32 ETO27392.1 - 7.8e-39 131.0 24.8 7.5e-07 29.8 1.7 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO27392.1 - 2.9e-12 46.0 5.5 0.18 10.4 0.1 5.5 3 1 1 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO27392.1 - 3.1e-10 40.2 5.0 0.44 10.9 0.0 5.7 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Kelch_4 PF13418.6 ETO27393.1 - 0.0029 17.6 0.2 0.23 11.5 0.1 3.4 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO27393.1 - 0.003 17.1 1.0 0.036 13.7 0.2 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO27393.1 - 0.0064 16.8 1.2 0.023 15.0 0.0 2.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO27393.1 - 0.0069 16.3 1.2 0.35 10.9 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO27393.1 - 0.031 14.6 1.1 37 4.8 0.1 4.0 4 0 0 4 4 4 0 Kelch motif Tubulin PF00091.25 ETO27394.1 - 4.1e-58 196.8 0.3 5.9e-58 196.3 0.3 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO27394.1 - 8.8e-36 122.8 0.1 1.6e-35 122.0 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO27394.1 - 0.053 12.7 0.1 0.09 12.0 0.1 1.3 1 0 0 1 1 1 0 Tubulin like HHH_8 PF14716.6 ETO27395.1 - 1.3e-15 57.5 2.4 2.4e-15 56.7 0.6 2.3 2 0 0 2 2 2 1 Helix-hairpin-helix domain DNA_pol_lambd_f PF10391.9 ETO27395.1 - 3.9e-14 52.2 0.0 9.3e-14 51.0 0.0 1.7 1 0 0 1 1 1 1 Fingers domain of DNA polymerase lambda WWE PF02825.20 ETO27395.1 - 2.4e-12 47.3 0.7 6e-12 46.0 0.1 2.1 2 0 0 2 2 2 1 WWE domain DNA_pol_B_palm PF14792.6 ETO27395.1 - 7.7e-07 29.3 0.0 2.3e-06 27.8 0.0 1.8 1 0 0 1 1 1 1 DNA polymerase beta palm HHH_5 PF14520.6 ETO27395.1 - 7.6e-05 23.2 0.2 0.75 10.4 0.0 2.6 2 0 0 2 2 2 2 Helix-hairpin-helix domain IMS_HHH PF11798.8 ETO27395.1 - 0.00054 20.1 0.1 0.14 12.6 0.1 3.3 2 1 1 3 3 3 1 IMS family HHH motif HHH PF00633.23 ETO27395.1 - 0.00058 19.6 1.3 0.96 9.4 0.1 2.7 2 0 0 2 2 2 2 Helix-hairpin-helix motif HHH_3 PF12836.7 ETO27395.1 - 0.047 13.9 0.3 6.3 7.1 0.0 2.8 1 1 2 3 3 3 0 Helix-hairpin-helix motif HHH_2 PF12826.7 ETO27395.1 - 0.13 12.4 0.0 6.9 6.9 0.0 2.4 1 1 1 2 2 2 0 Helix-hairpin-helix motif GWT1 PF06423.12 ETO27396.1 - 0.47 10.6 9.5 0.049 13.8 1.0 2.9 3 0 0 3 3 3 0 GWT1 tRNA-synt_1g PF09334.11 ETO27397.1 - 1.8e-67 227.8 3.6 8.3e-43 146.6 0.7 2.0 1 1 1 2 2 2 2 tRNA synthetases class I (M) tRNA-synt_1 PF00133.22 ETO27397.1 - 6.1e-15 54.5 4.4 2.7e-11 42.5 0.1 3.6 1 1 3 4 4 4 3 tRNA synthetases class I (I, L, M and V) tRNA-synt_1e PF01406.19 ETO27397.1 - 6.5e-09 35.6 1.8 9.2e-09 35.1 1.8 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain Ion_trans_2 PF07885.16 ETO27398.1 - 4.3e-19 68.3 19.4 1.2e-12 47.7 5.0 2.8 3 0 0 3 3 3 2 Ion channel EF-hand_1 PF00036.32 ETO27398.1 - 5.1e-10 38.2 1.2 0.00044 19.6 0.0 2.8 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO27398.1 - 5.5e-09 35.2 1.2 0.001 18.8 0.0 3.0 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO27398.1 - 8.2e-09 34.6 1.5 0.00021 20.6 0.0 2.9 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO27398.1 - 6.1e-07 29.8 3.7 0.023 15.2 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO27398.1 - 2.1e-05 24.3 0.5 0.11 12.3 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair Connexin PF00029.19 ETO27398.1 - 4.8e-05 23.2 0.4 0.00036 20.4 0.4 2.2 2 0 0 2 2 2 1 Connexin Ion_trans PF00520.31 ETO27398.1 - 0.0011 18.2 12.1 0.04 13.1 3.7 2.5 2 1 0 2 2 2 2 Ion transport protein Phage_Gp23 PF10669.9 ETO27398.1 - 0.0053 17.1 1.8 0.0053 17.1 1.8 2.4 3 0 0 3 3 2 1 Protein gp23 (Bacteriophage A118) DUF1682 PF07946.14 ETO27398.1 - 0.018 14.3 7.7 0.038 13.2 7.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) RP-C_C PF11800.8 ETO27398.1 - 0.024 14.8 0.1 0.051 13.7 0.1 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region Atrophin-1 PF03154.15 ETO27398.1 - 0.033 12.5 2.9 0.045 12.0 2.9 1.1 1 0 0 1 1 1 0 Atrophin-1 family FAM60A PF15396.6 ETO27398.1 - 0.051 13.6 1.0 0.36 10.8 0.4 2.5 3 0 0 3 3 3 0 Protein Family FAM60A DUF913 PF06025.12 ETO27398.1 - 0.07 12.1 0.2 0.11 11.5 0.2 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Peroxin-13_N PF04088.13 ETO27398.1 - 0.09 13.1 0.4 0.26 11.6 0.4 1.8 1 0 0 1 1 1 0 Peroxin 13, N-terminal region CobT PF06213.12 ETO27398.1 - 0.1 12.0 10.1 0.18 11.2 10.1 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Zip PF02535.22 ETO27398.1 - 0.18 11.0 0.0 0.34 10.1 0.0 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Pex14_N PF04695.13 ETO27398.1 - 0.26 11.9 3.6 0.7 10.5 2.8 2.0 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4834 PF16118.5 ETO27398.1 - 0.32 12.0 6.3 0.33 12.0 2.0 3.1 4 1 0 4 4 3 0 Domain of unknown function (DUF4834) MscS_TM PF12794.7 ETO27398.1 - 0.35 9.7 2.7 0.75 8.6 2.6 1.6 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 EMC3_TMCO1 PF01956.16 ETO27398.1 - 0.56 9.9 6.0 0.85 9.3 0.1 3.1 3 0 0 3 3 3 0 Integral membrane protein EMC3/TMCO1-like DUF3915 PF13054.6 ETO27398.1 - 4.3 7.3 5.9 9.7 6.2 5.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Sporozoite_P67 PF05642.11 ETO27398.1 - 5 5.1 5.8 7.3 4.5 5.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Peptidase_M17 PF00883.21 ETO27399.1 - 2.3e-83 280.1 0.9 7.1e-64 216.0 0.0 2.0 2 0 0 2 2 2 2 Cytosol aminopeptidase family, catalytic domain FSA_C PF10479.9 ETO27400.1 - 0.041 12.0 11.9 0.054 11.6 11.8 1.3 1 1 0 1 1 1 0 Fragile site-associated protein C-terminus Draxin PF15550.6 ETO27400.1 - 1.5 8.6 10.1 2.8 7.8 10.1 1.4 1 0 0 1 1 1 0 Draxin IHABP4_N PF16174.5 ETO27400.1 - 3 8.4 11.4 3.3 8.3 8.2 2.1 2 0 0 2 2 2 0 Intracellular hyaluronan-binding protein 4 N-terminal KCNQ2_u3 PF16642.5 ETO27400.1 - 6.2 7.9 8.1 1.3 10.0 0.7 2.3 2 0 0 2 2 2 0 Unstructured region on Potassium channel subunit alpha KvLQT2 SPG4 PF17325.2 ETO27400.1 - 9.9 7.3 9.0 0.45 11.6 0.3 2.7 2 1 0 2 2 2 0 Stationary phase protein 4 Kelch_1 PF01344.25 ETO27401.1 - 2.3e-08 33.5 0.9 3.4e-06 26.5 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO27401.1 - 2.2e-06 27.7 3.2 0.028 14.7 0.3 3.8 2 2 2 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO27401.1 - 3.3e-05 23.7 2.6 0.0033 17.4 0.3 3.0 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO27401.1 - 0.00021 21.2 1.1 0.014 15.3 0.1 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO27401.1 - 0.006 16.6 0.1 0.029 14.4 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO27401.1 - 0.015 15.6 0.1 1.3 9.4 0.0 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain KH_1 PF00013.29 ETO27402.1 - 8.4e-37 124.8 10.1 1.3e-15 57.0 2.2 3.5 3 0 0 3 3 3 3 KH domain KH_4 PF13083.6 ETO27402.1 - 1.1e-13 50.8 7.3 0.0019 18.1 0.0 4.7 4 1 1 5 5 5 3 KH domain KH_2 PF07650.17 ETO27402.1 - 1.6e-10 40.6 4.8 0.01 15.7 0.1 3.6 3 0 0 3 3 3 3 KH domain MOEP19 PF16005.5 ETO27402.1 - 8.9e-08 32.0 0.0 4.1e-06 26.7 0.0 2.7 3 0 0 3 3 3 1 KH-like RNA-binding domain KH_5 PF13184.6 ETO27402.1 - 0.00023 21.2 2.5 5.9 7.0 0.0 3.6 3 0 0 3 3 3 3 NusA-like KH domain DUF4747 PF15931.5 ETO27403.1 - 0.0078 15.9 0.9 0.01 15.5 0.9 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4747) Mo25 PF08569.11 ETO27404.1 - 7.8e-36 124.1 1.6 8.9e-36 123.9 1.6 1.0 1 0 0 1 1 1 1 Mo25-like tRNA_Me_trans PF03054.16 ETO27404.1 - 0.022 13.6 0.0 0.027 13.3 0.0 1.2 1 0 0 1 1 1 0 tRNA methyl transferase Sec8_exocyst PF04048.14 ETO27405.1 - 0.0004 20.3 19.7 0.00075 19.4 1.9 3.7 2 2 2 4 4 4 2 Sec8 exocyst complex component specific domain PspA_IM30 PF04012.12 ETO27405.1 - 0.0016 18.0 11.1 0.0016 18.0 11.1 2.5 2 1 0 2 2 2 1 PspA/IM30 family ING PF12998.7 ETO27405.1 - 0.003 18.1 1.6 0.003 18.1 1.6 3.6 2 2 1 3 3 3 1 Inhibitor of growth proteins N-terminal histone-binding BRE1 PF08647.11 ETO27405.1 - 0.012 15.6 7.5 0.012 15.6 7.5 4.3 3 1 0 4 4 4 0 BRE1 E3 ubiquitin ligase DUF4407 PF14362.6 ETO27405.1 - 0.14 11.5 22.8 0.046 13.1 14.1 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Golgin_A5 PF09787.9 ETO27405.1 - 0.41 10.1 35.2 0.16 11.4 15.2 2.3 1 1 0 2 2 2 0 Golgin subfamily A member 5 DUF2947 PF11163.8 ETO27405.1 - 0.56 10.0 11.4 0.14 12.0 4.1 2.6 2 2 0 2 2 2 0 Protein of unknown function (DUF2947) Tropomyosin_1 PF12718.7 ETO27405.1 - 0.75 10.0 37.6 3 8.0 8.9 3.2 2 1 1 3 3 3 0 Tropomyosin like FlaC_arch PF05377.11 ETO27405.1 - 0.99 9.8 14.0 6.4 7.3 0.5 4.5 4 1 0 4 4 4 0 Flagella accessory protein C (FlaC) Spc7 PF08317.11 ETO27405.1 - 1.2 7.9 34.2 1.1 8.1 10.6 3.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Lebercilin PF15619.6 ETO27405.1 - 1.3 8.7 37.6 0.39 10.3 6.6 3.3 2 1 1 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease Exonuc_VII_L PF02601.15 ETO27405.1 - 1.5 8.3 27.9 3 7.3 11.9 2.1 1 1 1 2 2 2 0 Exonuclease VII, large subunit Vicilin_N PF04702.12 ETO27405.1 - 1.6 8.6 24.6 0.013 15.3 6.6 2.1 1 1 1 2 2 2 0 Vicilin N terminal region Filament PF00038.21 ETO27405.1 - 1.9 8.0 32.5 0.3 10.6 8.6 3.1 1 1 2 3 3 3 0 Intermediate filament protein FAM76 PF16046.5 ETO27405.1 - 2.4 7.4 29.7 0.49 9.7 3.6 3.1 2 1 1 3 3 3 0 FAM76 protein GAS PF13851.6 ETO27405.1 - 2.5 7.4 40.1 2.5 7.4 8.9 3.3 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding SHE3 PF17078.5 ETO27405.1 - 2.7 7.7 30.3 0.52 10.0 23.1 2.7 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Matrilin_ccoil PF10393.9 ETO27405.1 - 3.2 7.7 11.0 1.7 8.5 0.2 4.3 3 1 1 4 4 4 0 Trimeric coiled-coil oligomerisation domain of matrilin TSA PF03249.13 ETO27405.1 - 4.4 6.0 8.5 6.7 5.4 8.4 1.3 1 1 0 1 1 1 0 Type specific antigen Fib_alpha PF08702.10 ETO27405.1 - 4.4 7.5 24.8 7.5 6.7 5.8 3.2 1 1 2 3 3 3 0 Fibrinogen alpha/beta chain family Fzo_mitofusin PF04799.13 ETO27405.1 - 4.8 6.7 27.8 0.66 9.5 6.4 3.5 2 1 1 3 3 3 0 fzo-like conserved region YabA PF06156.13 ETO27405.1 - 4.9 7.9 27.2 3.6 8.3 3.2 4.2 2 1 2 4 4 4 0 Initiation control protein YabA RACo_linker PF17650.1 ETO27405.1 - 5 7.1 7.1 1.9 8.4 0.1 3.2 3 2 1 4 4 4 0 RACo linker region Cut12 PF11500.8 ETO27405.1 - 9.1 6.2 27.3 1.3 8.9 14.5 3.1 2 1 1 3 3 3 0 Spindle pole body formation-associated protein PCI PF01399.27 ETO27406.1 - 0.017 15.6 0.1 0.042 14.4 0.0 1.6 2 0 0 2 2 2 0 PCI domain DUF3128 PF11326.8 ETO27407.1 - 0.04 14.3 2.2 9.6 6.7 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3128) TPR_2 PF07719.17 ETO27407.1 - 0.069 13.3 3.9 34 4.9 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO27407.1 - 0.17 12.4 0.1 8.4 7.0 0.0 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO27407.1 - 0.31 11.3 3.6 13 6.1 0.0 3.2 4 0 0 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2756 PF10956.8 ETO27408.1 - 0.07 13.6 2.4 0.24 11.9 2.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2756) zf-CCCH PF00642.24 ETO27410.1 - 1.4e-17 63.1 41.6 9e-05 22.3 4.0 5.2 4 1 1 5 5 5 5 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO27410.1 - 5e-14 51.8 46.9 5.3e-06 26.3 1.8 6.1 5 1 0 5 5 5 4 Zinc finger domain Torus PF16131.5 ETO27410.1 - 3.7e-08 34.0 25.7 0.004 17.8 0.5 4.8 1 1 4 5 5 5 4 Torus domain zf-CCCH_3 PF15663.5 ETO27410.1 - 6.1e-08 32.9 8.0 6.1e-08 32.9 8.0 2.9 1 1 2 3 3 3 1 Zinc-finger containing family zf-CCCH_2 PF14608.6 ETO27410.1 - 0.00032 21.1 50.4 0.12 12.8 6.9 6.1 7 0 0 7 7 7 4 RNA-binding, Nab2-type zinc finger zf-CCCH_4 PF18044.1 ETO27410.1 - 0.00063 19.5 0.3 0.00063 19.5 0.3 5.4 5 1 0 5 5 5 3 CCCH-type zinc finger zf-C3H1 PF10650.9 ETO27410.1 - 0.042 13.6 0.1 0.042 13.6 0.1 5.6 5 1 0 5 5 5 0 Putative zinc-finger domain GHL15 PF14885.6 ETO27411.1 - 1.3e-05 25.3 0.2 0.029 14.4 0.1 2.3 2 0 0 2 2 2 2 Hypothetical glycosyl hydrolase family 15 PI_PP_I PF18363.1 ETO27411.1 - 0.99 9.6 5.1 6.8 6.9 0.1 3.4 4 0 0 4 4 4 0 Phosphoinositide phosphatase insertion domain FeoB_associated PF12669.7 ETO27412.1 - 3.5 8.1 6.4 14 6.2 0.2 3.6 3 0 0 3 3 3 0 FeoB-associated Cys-rich membrane protein Hydrolase_4 PF12146.8 ETO27413.1 - 6e-27 94.4 0.0 8.8e-27 93.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_6 PF12697.7 ETO27413.1 - 6e-05 23.7 0.0 8.3e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_3 PF07859.13 ETO27413.1 - 0.0021 18.0 0.0 0.0028 17.5 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_1 PF00561.20 ETO27413.1 - 0.012 15.2 0.0 0.072 12.7 0.0 2.0 1 1 0 2 2 2 0 alpha/beta hydrolase fold NINJA_B PF16136.5 ETO27413.1 - 0.058 13.8 0.3 0.097 13.1 0.3 1.4 1 0 0 1 1 1 0 Putative nuclear localisation signal Esterase PF00756.20 ETO27413.1 - 0.14 11.7 0.0 0.36 10.4 0.0 1.6 2 0 0 2 2 2 0 Putative esterase PYST-C1 PF09690.10 ETO27414.1 - 0.04 13.6 0.6 0.1 12.4 0.6 1.7 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) RVT_1 PF00078.27 ETO27415.1 - 3.3e-34 118.3 1.2 3.3e-34 118.3 1.2 2.9 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) zf-Di19 PF05605.12 ETO27415.1 - 2.1 8.7 5.7 0.93 9.8 1.0 2.5 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Orf78 PF06024.12 ETO27416.1 - 0.11 12.8 3.2 0.2 12.0 0.2 2.6 2 0 0 2 2 2 0 Orf78 (ac78) ETRAMP PF09716.10 ETO27416.1 - 5.1 7.2 16.8 1.7 8.8 7.6 3.4 2 2 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) NACHT PF05729.12 ETO27417.1 - 2e-18 66.9 0.0 8.3e-18 64.8 0.0 2.1 1 0 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO27417.1 - 5.2e-07 30.2 0.0 4e-05 24.1 0.0 2.9 2 0 0 2 2 2 1 AAA ATPase domain HEAT PF02985.22 ETO27417.1 - 4.1e-06 26.6 0.6 0.041 14.1 0.0 4.8 4 0 0 4 4 4 1 HEAT repeat NB-ARC PF00931.22 ETO27417.1 - 8e-05 21.9 0.1 8e-05 21.9 0.1 2.5 3 0 0 3 3 3 1 NB-ARC domain HEAT_2 PF13646.6 ETO27417.1 - 0.00021 21.6 0.0 2 8.9 0.0 3.4 2 1 1 3 3 3 3 HEAT repeats KicB PF03882.14 ETO27417.1 - 0.015 15.5 0.4 18 5.6 0.0 3.9 3 0 0 3 3 3 0 MukF winged-helix domain DUF87 PF01935.17 ETO27417.1 - 0.16 12.1 11.1 3 7.9 0.0 3.9 4 0 0 4 4 4 0 Helicase HerA, central domain NLRC4_HD2 PF17776.1 ETO27417.1 - 0.25 11.9 0.0 0.25 11.9 0.0 5.4 5 3 2 7 7 7 0 NLRC4 helical domain HD2 Vac14_Fab1_bd PF12755.7 ETO27417.1 - 0.5 11.0 8.9 3.2 8.4 0.7 4.5 3 1 1 4 4 4 0 Vacuolar 14 Fab1-binding region AAA_18 PF13238.6 ETO27417.1 - 0.83 10.2 4.5 1.6 9.2 0.0 3.8 5 0 0 5 5 5 0 AAA domain DUF4428 PF14471.6 ETO27417.1 - 5.5 7.0 7.5 0.73 9.8 0.3 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) Pkinase PF00069.25 ETO27419.1 - 0.007 15.8 0.0 0.011 15.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain G-alpha PF00503.20 ETO27420.1 - 4.2e-59 200.5 10.2 5.1e-59 200.2 10.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO27420.1 - 1.9e-07 30.7 0.9 4.3e-07 29.5 0.9 1.6 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO27420.1 - 9.7e-07 28.4 1.2 1.9e-06 27.4 0.5 1.8 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region CDC45 PF02724.14 ETO27421.1 - 0.19 10.0 13.8 0.24 9.7 13.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Ureide_permease PF07168.11 ETO27421.1 - 2.1 7.0 4.3 2.4 6.8 4.3 1.2 1 0 0 1 1 1 0 Ureide permease Presenilin PF01080.17 ETO27421.1 - 2.2 6.9 14.6 2.3 6.9 14.6 1.1 1 0 0 1 1 1 0 Presenilin Paramyxo_ncap PF00973.19 ETO27421.1 - 2.3 7.0 7.8 2.4 7.0 7.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Dsh_C PF12316.8 ETO27421.1 - 3.1 8.1 11.2 3.7 7.9 11.2 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Neur_chan_memb PF02932.16 ETO27421.1 - 3.2 7.8 8.2 3.4 7.7 8.2 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region ALMT PF11744.8 ETO27421.1 - 4.1 6.1 10.9 4.8 5.9 10.9 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 ETO27421.1 - 4.1 6.5 11.1 4.8 6.3 11.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO27421.1 - 7.9 5.2 18.3 7.4 5.2 18.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Apt1 PF10351.9 ETO27421.1 - 9.2 5.0 19.4 9.3 5.0 19.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Macoilin PF09726.9 ETO27421.1 - 9.5 4.6 17.7 9.1 4.7 17.7 1.0 1 0 0 1 1 1 0 Macoilin family WD40 PF00400.32 ETO27422.1 - 9.7e-06 26.2 1.3 0.033 15.1 0.3 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat Menin PF05053.13 ETO27422.1 - 0.078 11.3 5.3 0.16 10.3 5.3 1.5 1 0 0 1 1 1 0 Menin ANAPC4_WD40 PF12894.7 ETO27422.1 - 0.078 13.3 0.0 15 6.0 0.0 3.1 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain Zip PF02535.22 ETO27422.1 - 0.56 9.4 6.6 1.6 7.9 2.5 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Sigma70_ner PF04546.13 ETO27422.1 - 3 7.7 14.7 0.83 9.5 7.5 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region CDC45 PF02724.14 ETO27422.1 - 3.6 5.8 24.6 0.67 8.2 4.7 2.1 2 0 0 2 2 2 0 CDC45-like protein PI3K_1B_p101 PF10486.9 ETO27422.1 - 8.9 4.0 13.1 0.8 7.4 4.4 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Gly_acyl_tr_N PF06021.11 ETO27423.1 - 0.65 10.1 15.1 0.018 15.1 1.9 2.0 1 1 1 2 2 2 0 Aralkyl acyl-CoA:amino acid N-acyltransferase GAGA_bind PF06217.12 ETO27423.1 - 4.9 7.4 15.9 6.4 7.0 15.9 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family EF-hand_1 PF00036.32 ETO27424.1 - 0.019 14.5 1.2 0.038 13.5 0.1 2.2 2 0 0 2 2 2 0 EF hand SR1P PF13790.6 ETO27424.1 - 0.12 12.6 1.4 0.2 11.8 1.4 1.3 1 0 0 1 1 1 0 SR1 protein EF-hand_7 PF13499.6 ETO27424.1 - 0.21 12.1 2.9 2.8 8.5 0.0 3.1 2 1 0 2 2 2 0 EF-hand domain pair Crisp PF08562.10 ETO27425.1 - 0.049 14.2 0.8 0.049 14.2 0.8 2.3 2 0 0 2 2 2 0 Crisp NCD3G PF07562.14 ETO27425.1 - 0.073 13.1 7.2 2 8.5 0.2 3.3 3 0 0 3 3 3 0 Nine Cysteines Domain of family 3 GPCR Ephrin_rec_like PF07699.13 ETO27425.1 - 5.7 6.8 9.2 0.33 10.7 1.1 2.8 2 0 0 2 2 2 0 Putative ephrin-receptor like Med4 PF10018.9 ETO27427.1 - 6.9e-06 25.9 0.9 6.9e-06 25.9 0.9 2.2 2 0 0 2 2 2 1 Vitamin-D-receptor interacting Mediator subunit 4 Ribosomal_60s PF00428.19 ETO27427.1 - 0.052 14.1 0.1 0.11 13.1 0.1 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Latarcin PF10279.9 ETO27427.1 - 0.057 13.8 0.0 0.057 13.8 0.0 1.9 2 1 0 2 2 2 0 Latarcin precursor EIIBC-GUT_N PF03612.14 ETO27427.1 - 0.07 12.9 1.5 0.16 11.7 0.9 1.8 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus DNApol3-delta_C PF09115.10 ETO27427.1 - 0.17 12.4 7.9 0.067 13.7 4.1 2.3 2 0 0 2 2 2 0 DNA polymerase III, delta subunit, C terminal WD40 PF00400.32 ETO27428.1 - 2.1e-47 158.1 20.7 1.8e-08 34.9 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27428.1 - 1.8e-16 60.2 2.8 0.017 15.4 0.0 6.3 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27428.1 - 3.1e-11 42.8 4.0 0.053 12.5 0.0 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27428.1 - 1.2e-06 28.1 3.7 0.0016 17.8 0.2 3.0 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO27428.1 - 1.7e-06 27.0 3.0 0.14 10.8 0.1 3.8 2 2 1 3 3 3 3 Nucleoporin Nup120/160 NHL PF01436.21 ETO27428.1 - 0.0054 16.7 1.2 0.5 10.5 0.1 3.5 4 0 0 4 4 4 1 NHL repeat Cytochrom_D1 PF02239.16 ETO27428.1 - 0.0082 14.7 1.3 0.04 12.4 0.4 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain Utp8 PF10395.9 ETO27428.1 - 0.01 14.4 0.4 0.65 8.4 0.1 3.0 2 1 0 3 3 3 0 Utp8 family PQQ_2 PF13360.6 ETO27428.1 - 0.047 13.3 0.3 0.34 10.5 0.3 2.0 1 1 0 1 1 1 0 PQQ-like domain PD40 PF07676.12 ETO27428.1 - 0.048 13.6 1.9 63 3.7 0.2 4.3 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO27428.1 - 0.089 12.4 0.0 8.1 6.2 0.0 3.1 3 0 0 3 3 3 0 HepA-related protein (HARP) MAP17 PF15807.5 ETO27429.1 - 0.018 15.2 1.0 0.55 10.5 0.1 2.4 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 CBFB_NFYA PF02045.15 ETO27431.1 - 1.4e-15 57.6 8.8 2.9e-15 56.6 8.8 1.6 1 0 0 1 1 1 1 CCAAT-binding transcription factor (CBF-B/NF-YA) subunit B CCT PF06203.14 ETO27431.1 - 0.0036 17.3 1.5 0.0066 16.5 1.5 1.5 1 0 0 1 1 1 1 CCT motif DUF3123 PF11321.8 ETO27432.1 - 0.95 10.2 5.2 1 10.0 4.3 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3123) UQ_con PF00179.26 ETO27438.1 - 7e-44 148.9 0.4 4e-42 143.2 0.0 2.2 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO27438.1 - 4.6e-06 26.4 0.3 1.1e-05 25.1 0.0 1.7 2 0 0 2 2 2 1 Prokaryotic E2 family B UEV PF05743.13 ETO27438.1 - 0.021 14.7 0.0 0.046 13.6 0.0 1.5 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 ETO27438.1 - 0.046 14.0 0.1 0.12 12.7 0.0 1.7 2 0 0 2 2 2 0 RWD domain TSNAXIP1_N PF15739.5 ETO27438.1 - 1.3 9.4 5.4 0.32 11.4 2.4 1.5 2 0 0 2 2 2 0 Translin-associated factor X-interacting N-terminus Asp_Arg_Hydrox PF05118.15 ETO27439.1 - 4e-07 30.0 0.0 5.4e-07 29.6 0.0 1.2 1 0 0 1 1 1 1 Aspartyl/Asparaginyl beta-hydroxylase Ras PF00071.22 ETO27440.1 - 3.7e-29 101.4 1.5 7.5e-29 100.4 0.3 1.9 1 1 1 2 2 2 1 Ras family Roc PF08477.13 ETO27440.1 - 3.8e-15 56.1 0.1 3.4e-14 53.1 0.0 2.2 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO27440.1 - 0.0003 20.3 0.0 0.00053 19.5 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO27440.1 - 0.0048 17.0 0.0 0.014 15.5 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP_EFTU PF00009.27 ETO27440.1 - 0.035 13.6 0.1 0.11 12.0 0.0 1.7 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain HORMA PF02301.18 ETO27441.1 - 0.043 13.4 3.7 0.097 12.2 3.7 1.7 1 1 0 1 1 1 0 HORMA domain DUF4776 PF16003.5 ETO27442.1 - 0.75 8.7 11.0 1.1 8.2 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4776) Kelch_4 PF13418.6 ETO27444.1 - 9.7e-05 22.3 0.2 0.00056 19.9 0.1 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO27444.1 - 0.00078 19.6 1.2 0.63 10.4 0.1 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO27444.1 - 0.018 15.3 0.0 1.6 9.1 0.0 2.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO27444.1 - 0.027 14.0 3.1 31 4.3 0.1 4.4 4 1 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO27444.1 - 0.15 12.1 0.6 37 4.5 0.0 4.0 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO27446.1 - 9.1e-39 130.8 31.9 1.7e-06 28.6 1.3 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27446.1 - 5.9e-12 45.7 4.7 0.37 11.1 0.0 6.2 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27446.1 - 7.1e-10 38.2 15.6 0.0073 15.0 0.6 6.1 3 3 2 6 6 6 6 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO27446.1 - 3.6e-06 27.6 2.7 3.6e-06 27.6 2.7 2.8 3 0 0 3 3 3 1 TRAF-type zinc finger WD40_like PF17005.5 ETO27446.1 - 0.0023 17.3 12.3 0.086 12.2 0.3 4.6 3 2 1 5 5 5 2 WD40-like domain BLF1 PF17752.1 ETO27446.1 - 0.032 13.5 0.1 0.069 12.4 0.1 1.5 1 0 0 1 1 1 0 Burkholderia lethal factor 1 Ecotin PF03974.13 ETO27446.1 - 0.26 11.3 3.7 3.8 7.5 0.1 3.3 4 0 0 4 4 4 0 Ecotin WD40 PF00400.32 ETO27447.1 - 1.3e-34 117.6 26.3 1.2e-06 29.1 0.2 7.4 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27447.1 - 8.7e-09 35.6 3.2 0.035 14.4 0.0 5.2 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO27447.1 - 0.00026 21.6 5.6 0.00033 21.3 3.4 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger SH2 PF00017.24 ETO27447.1 - 0.2 11.8 2.3 0.97 9.6 0.0 3.4 4 0 0 4 4 4 0 SH2 domain DASH_Spc34 PF08657.10 ETO27447.1 - 3.5 7.4 17.6 14 5.4 15.0 2.4 1 1 1 2 2 2 0 DASH complex subunit Spc34 LRRFIP PF09738.9 ETO27447.1 - 6.2 6.2 18.6 0.66 9.4 13.6 1.8 2 0 0 2 2 2 0 LRRFIP family NuiA PF07924.11 ETO27448.1 - 0.12 12.8 1.4 1.7 9.1 0.1 2.2 2 0 0 2 2 2 0 Nuclease A inhibitor-like protein FmdE PF02663.14 ETO27448.1 - 0.34 11.0 2.9 0.24 11.5 0.3 1.9 2 0 0 2 2 2 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Cullin_Nedd8 PF10557.9 ETO27449.1 - 0.064 13.3 1.2 0.22 11.6 0.3 2.4 2 0 0 2 2 2 0 Cullin protein neddylation domain Laminin_II PF06009.12 ETO27449.1 - 0.44 10.6 20.6 0.11 12.5 3.1 4.6 3 2 1 5 5 5 0 Laminin Domain II DUF4349 PF14257.6 ETO27449.1 - 9.3 5.6 14.7 0.21 11.0 4.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4349) NTP_transf_2 PF01909.23 ETO27450.1 - 1.1e-06 28.9 0.0 2.4e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 Nucleotidyltransferase domain PAP_central PF04928.17 ETO27450.1 - 0.0045 16.0 0.0 0.0064 15.5 0.0 1.2 1 0 0 1 1 1 1 Poly(A) polymerase central domain Polbeta PF18765.1 ETO27450.1 - 0.11 12.5 0.6 0.26 11.4 0.0 1.9 2 0 0 2 2 2 0 Polymerase beta, Nucleotidyltransferase DUF3439 PF11921.8 ETO27451.1 - 0.017 15.1 2.4 0.045 13.7 2.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) WD40 PF00400.32 ETO27452.1 - 3e-32 110.1 9.1 3.3e-09 37.2 0.0 5.1 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27452.1 - 9.6e-11 41.8 1.0 0.0025 18.1 0.1 4.4 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27452.1 - 8.8e-08 31.2 5.4 0.0049 15.6 0.1 3.9 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO27452.1 - 5.4e-06 26.0 0.2 0.00072 19.0 0.1 2.2 2 0 0 2 2 2 2 WD40-like domain Pkinase PF00069.25 ETO27453.1 - 2.1e-12 46.9 0.0 3.6e-12 46.2 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27453.1 - 0.019 14.3 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase TFIIF_alpha PF05793.12 ETO27454.1 - 0.85 8.1 35.5 0.96 8.0 35.5 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF3987 PF13148.6 ETO27454.1 - 2.3 7.1 5.8 3 6.8 5.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) Phage_Gp23 PF10669.9 ETO27454.1 - 3.2 8.1 18.9 7 7.0 18.9 1.6 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) F-protein PF00469.20 ETO27454.1 - 5.4 6.6 18.0 7.4 6.1 11.2 2.1 2 0 0 2 2 2 0 Negative factor, (F-Protein) or Nef Spt5_N PF11942.8 ETO27455.1 - 0.0045 17.9 8.5 0.0074 17.2 8.5 1.4 1 0 0 1 1 1 1 Spt5 transcription elongation factor, acidic N-terminal YL1 PF05764.13 ETO27455.1 - 0.0056 16.8 3.0 0.0056 16.8 3.0 1.1 1 0 0 1 1 1 1 YL1 nuclear protein TFIIF_alpha PF05793.12 ETO27455.1 - 0.013 14.1 11.3 0.015 14.0 11.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 ETO27455.1 - 0.21 9.8 10.0 0.25 9.6 10.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Osteopontin PF00865.18 ETO27455.1 - 0.21 11.0 21.2 0.26 10.8 21.2 1.2 1 0 0 1 1 1 0 Osteopontin Nop14 PF04147.12 ETO27455.1 - 3 5.9 13.8 3.4 5.8 13.8 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO27455.1 - 5.2 6.4 14.8 6.3 6.1 14.8 1.1 1 0 0 1 1 1 0 SDA1 Sigma70_ner PF04546.13 ETO27455.1 - 6 6.7 8.3 7.4 6.4 8.3 1.2 1 0 0 1 1 1 0 Sigma-70, non-essential region PUF PF00806.19 ETO27456.1 - 1.5e-21 74.8 4.5 6.2e-05 22.5 0.1 4.5 4 0 0 4 4 4 4 Pumilio-family RNA binding repeat PH PF00169.29 ETO27458.1 - 9.1e-05 22.9 0.0 0.00029 21.3 0.0 1.8 1 0 0 1 1 1 1 PH domain BicD PF09730.9 ETO27458.1 - 0.013 14.0 0.8 0.019 13.4 0.8 1.2 1 0 0 1 1 1 0 Microtubule-associated protein Bicaudal-D UPF0160 PF03690.13 ETO27458.1 - 0.071 12.7 1.4 0.11 12.1 0.1 1.9 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0160) Exonuc_VII_L PF02601.15 ETO27458.1 - 0.29 10.7 1.4 0.44 10.1 1.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit PhyH PF05721.13 ETO27459.1 - 2.4e-09 37.8 0.0 4.2e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Ni_hydr_CYTB PF01292.20 ETO27460.1 - 0.016 14.9 2.6 0.019 14.6 2.6 1.1 1 0 0 1 1 1 0 Prokaryotic cytochrome b561 Bac_rhodopsin PF01036.18 ETO27460.1 - 0.028 14.0 3.3 0.036 13.6 3.3 1.2 1 0 0 1 1 1 0 Bacteriorhodopsin-like protein Sh_2 PF17512.2 ETO27460.1 - 0.055 13.2 8.3 0.19 11.5 1.9 2.1 1 1 1 2 2 2 0 Metapneumovirus Small hydrophobic protein GWT1 PF06423.12 ETO27460.1 - 0.056 13.6 3.2 0.074 13.2 3.2 1.1 1 0 0 1 1 1 0 GWT1 HXXEE PF13787.6 ETO27460.1 - 0.12 13.1 7.0 0.17 12.7 7.0 1.2 1 0 0 1 1 1 0 Protein of unknown function with HXXEE motif DUF2207 PF09972.9 ETO27460.1 - 1.2 7.8 3.3 1.4 7.6 3.3 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) HECT PF00632.25 ETO27461.1 - 4.4e-54 184.0 0.0 8.7e-54 183.1 0.0 1.4 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.6 ETO27461.1 - 5.1e-13 49.4 0.1 1.3e-12 48.2 0.1 1.6 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 ETO27461.1 - 1.6e-05 25.5 0.0 4e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 Laminin G domain RICTOR_N PF14664.6 ETO27461.1 - 0.012 14.6 0.1 0.03 13.3 0.0 1.6 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Laminin_G_1 PF00054.23 ETO27461.1 - 0.017 15.3 0.1 0.039 14.2 0.1 1.5 1 0 0 1 1 1 0 Laminin G domain Tetraspanin PF00335.20 ETO27462.1 - 8.3e-22 78.0 15.2 1.2e-21 77.5 15.2 1.3 1 0 0 1 1 1 1 Tetraspanin family DUF2569 PF10754.9 ETO27462.1 - 0.039 14.4 1.4 0.039 14.4 1.4 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2569) Ac76 PF05814.11 ETO27462.1 - 0.051 13.6 0.6 0.051 13.6 0.6 2.4 3 0 0 3 3 3 0 Orf76 (Ac76) DUF2070 PF09843.9 ETO27462.1 - 1.3 7.2 12.5 0.023 13.0 4.4 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) DUF5079 PF16882.5 ETO27463.1 - 0.32 10.9 6.2 0.21 11.4 1.9 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF5079) RHD_DNA_bind PF00554.22 ETO27464.1 - 0.021 14.8 1.3 0.33 10.9 0.0 2.1 2 0 0 2 2 2 0 Rel homology DNA-binding domain Alpha-mann_mid PF09261.11 ETO27464.1 - 0.14 12.3 0.7 9.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Alpha mannosidase middle domain PH PF00169.29 ETO27466.1 - 1.3e-06 28.9 0.1 1.3e-06 28.9 0.1 2.2 2 0 0 2 2 2 1 PH domain EF-hand_7 PF13499.6 ETO27466.1 - 0.00064 20.1 2.3 0.69 10.4 0.2 3.4 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO27466.1 - 0.00073 19.3 3.6 4.3 7.5 1.1 3.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO27466.1 - 0.0052 16.3 10.7 0.25 11.0 1.2 3.9 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ETO27466.1 - 0.038 13.8 0.9 0.12 12.3 0.5 2.1 2 0 0 2 2 2 0 EF-hand domain pair Zip PF02535.22 ETO27466.1 - 0.094 11.9 4.0 0.032 13.5 0.4 1.9 2 0 0 2 2 2 0 ZIP Zinc transporter Presenilin PF01080.17 ETO27466.1 - 0.22 10.3 5.5 0.39 9.4 5.5 1.4 1 0 0 1 1 1 0 Presenilin Nudix_N_2 PF14803.6 ETO27466.1 - 0.98 9.4 3.5 0.77 9.7 0.1 2.4 2 1 0 3 3 3 0 Nudix N-terminal RP-C_C PF11800.8 ETO27466.1 - 1.9 8.6 4.1 5.1 7.1 4.1 1.7 1 0 0 1 1 1 0 Replication protein C C-terminal region CN_hydrolase PF00795.22 ETO27467.1 - 1.9e-16 60.2 0.0 2.3e-16 59.9 0.0 1.0 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase Bap31 PF05529.12 ETO27468.1 - 4.8 7.0 11.0 0.054 13.4 0.9 2.2 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region EF-hand_6 PF13405.6 ETO27470.1 - 9e-05 22.1 1.4 0.019 14.8 0.0 3.6 4 0 0 4 4 4 1 EF-hand domain EF-hand_1 PF00036.32 ETO27470.1 - 0.0025 17.2 0.0 0.59 9.8 0.0 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO27470.1 - 0.0036 17.7 1.1 0.014 15.8 0.8 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_8 PF13833.6 ETO27470.1 - 0.24 11.3 8.2 0.49 10.3 1.1 3.8 3 1 0 3 3 3 0 EF-hand domain pair O-FucT PF10250.9 ETO27471.1 - 2.2e-14 53.9 0.6 2.8e-14 53.6 0.6 1.1 1 0 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Pkinase PF00069.25 ETO27472.1 - 1.2e-35 123.2 2.8 1.3e-35 123.1 2.8 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27472.1 - 3.3e-21 75.7 0.7 3.7e-21 75.6 0.7 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase FTA2 PF13095.6 ETO27472.1 - 0.00011 21.9 1.0 0.091 12.4 0.0 2.1 1 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ETO27472.1 - 0.1 12.5 0.0 1 9.3 0.0 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Connexin PF00029.19 ETO27473.1 - 0.099 12.4 0.2 0.11 12.3 0.2 1.0 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 ETO27473.1 - 0.22 10.4 0.5 0.24 10.3 0.5 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator DUF2448 PF10476.9 ETO27473.1 - 0.23 11.3 0.1 0.26 11.1 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2448) Menin PF05053.13 ETO27473.1 - 1.5 7.1 7.3 1.4 7.2 7.3 1.0 1 0 0 1 1 1 0 Menin PT PF04886.12 ETO27474.1 - 1e-25 89.0 169.9 7.7e-09 34.9 24.6 9.3 4 2 2 6 6 6 3 PT repeat GSu_C4xC__C2xCH PF09698.10 ETO27474.1 - 3.5 8.5 6.6 0.62 10.9 1.0 2.7 2 0 0 2 2 2 0 Geobacter CxxxxCH...CXXCH motif (GSu_C4xC__C2xCH) peroxidase PF00141.23 ETO27475.1 - 5.3e-35 121.2 0.0 6.9e-35 120.8 0.0 1.2 1 0 0 1 1 1 1 Peroxidase ATP13 PF12921.7 ETO27475.1 - 0.16 11.9 0.0 0.95 9.3 0.0 2.0 2 0 0 2 2 2 0 Mitochondrial ATPase expression FAA_hydrolase PF01557.18 ETO27476.1 - 4.1e-09 36.4 0.0 4.9e-09 36.2 0.0 1.0 1 0 0 1 1 1 1 Fumarylacetoacetate (FAA) hydrolase family Cdc6_C PF09079.11 ETO27476.1 - 0.024 14.6 0.0 0.042 13.8 0.0 1.4 1 0 0 1 1 1 0 CDC6, C terminal winged helix domain WW PF00397.26 ETO27477.1 - 6.1e-07 29.4 1.8 6.1e-07 29.4 1.8 2.2 2 0 0 2 2 2 1 WW domain Glyco_hyd_101C PF17451.2 ETO27477.1 - 0.11 12.7 0.1 0.11 12.7 0.1 2.3 2 1 0 2 2 2 0 Glycosyl hydrolase 101 beta sandwich domain FF PF01846.19 ETO27478.1 - 9.4e-12 44.9 1.6 2.7e-11 43.5 0.4 2.2 2 0 0 2 2 2 1 FF domain PRCH PF03967.13 ETO27478.1 - 0.21 11.8 2.1 0.59 10.4 0.4 2.1 2 0 0 2 2 2 0 Photosynthetic reaction centre, H-chain N-terminal region Mucin PF01456.17 ETO27479.1 - 2.1 8.3 18.5 5.3 7.0 18.5 1.7 1 0 0 1 1 1 0 Mucin-like glycoprotein SWI-SNF_Ssr4 PF08549.10 ETO27479.1 - 3.7 6.1 25.4 5.5 5.5 25.4 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Bac_rhamnosid6H PF17389.2 ETO27481.1 - 2.1e-29 102.9 0.0 4.7e-29 101.7 0.0 1.6 1 0 0 1 1 1 1 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Pkinase PF00069.25 ETO27482.1 - 1.4e-12 47.6 0.0 2.6e-11 43.4 0.0 2.2 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27482.1 - 0.014 14.7 0.0 1.7 7.8 0.0 2.2 2 0 0 2 2 2 0 Protein tyrosine kinase CDC45 PF02724.14 ETO27482.1 - 0.87 7.8 3.2 1.1 7.4 3.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Gly-zipper_Omp PF13488.6 ETO27483.1 - 0.0065 16.5 0.8 0.013 15.4 0.8 1.5 1 0 0 1 1 1 1 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO27483.1 - 0.14 11.9 0.9 0.3 10.9 0.9 1.4 1 0 0 1 1 1 0 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 ETO27483.1 - 0.18 11.7 2.7 1.9 8.4 2.7 2.2 1 1 0 1 1 1 0 Glycine zipper 2TM domain DUF1656 PF07869.12 ETO27483.1 - 5 7.2 11.3 5.4 7.1 1.9 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1656) AMP-binding_C_2 PF14535.6 ETO27485.1 - 0.016 15.5 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 AMP-binding enzyme C-terminal domain TRIQK PF15168.6 ETO27485.1 - 0.11 12.4 0.3 0.25 11.3 0.3 1.5 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family Nexin_C PF08628.12 ETO27486.1 - 0.028 15.0 0.1 0.055 14.1 0.1 1.5 1 0 0 1 1 1 0 Sorting nexin C terminal NDUFA12 PF05071.16 ETO27487.1 - 0.97 10.3 6.7 0.36 11.7 0.4 3.1 3 0 0 3 3 3 0 NADH ubiquinone oxidoreductase subunit NDUFA12 DUF4276 PF14103.6 ETO27487.1 - 3.2 8.0 6.5 4.5 7.5 0.4 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4276) Pox_Ag35 PF03286.14 ETO27489.1 - 1.2 8.9 5.9 1.7 8.4 5.9 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Presenilin PF01080.17 ETO27489.1 - 5.9 5.5 10.7 6.1 5.5 10.7 1.2 1 0 0 1 1 1 0 Presenilin ZapB PF06005.12 ETO27490.1 - 0.0059 17.0 3.0 0.033 14.6 1.1 2.3 2 0 0 2 2 2 1 Cell division protein ZapB HALZ PF02183.18 ETO27490.1 - 0.019 15.2 3.9 0.041 14.1 2.4 2.1 1 1 1 2 2 2 0 Homeobox associated leucine zipper JIP_LZII PF16471.5 ETO27490.1 - 0.04 14.1 2.4 0.053 13.7 0.5 2.0 2 0 0 2 2 2 0 JNK-interacting protein leucine zipper II DUF2972 PF11186.8 ETO27490.1 - 0.075 12.9 1.2 0.084 12.8 0.5 1.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2972) DUF3450 PF11932.8 ETO27490.1 - 0.16 11.2 2.9 0.16 11.2 2.4 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) Glyco_transf_24 PF18404.1 ETO27492.1 - 1.2e-97 326.6 5.6 1.5e-84 283.5 2.5 2.0 2 0 0 2 2 2 2 Glucosyltransferase 24 Glyco_transf_8 PF01501.20 ETO27492.1 - 1e-06 28.5 0.0 1.3e-06 28.2 0.0 1.2 1 0 0 1 1 1 1 Glycosyl transferase family 8 UDP-g_GGTase PF06427.11 ETO27493.1 - 9.1e-29 99.8 0.0 3e-28 98.1 0.0 2.0 1 0 0 1 1 1 1 UDP-glucose:Glycoprotein Glucosyltransferase Thioredoxin_14 PF18402.1 ETO27493.1 - 9.8e-22 78.1 10.2 1.3e-20 74.4 2.9 3.4 3 0 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_13 PF18401.1 ETO27493.1 - 7e-10 39.0 2.0 1.4e-08 34.7 0.1 3.2 3 0 0 3 3 3 1 Thioredoxin-like domain Thioredoxin_12 PF18400.1 ETO27493.1 - 5.7e-09 36.1 1.1 1.4e-08 34.8 0.3 2.1 2 0 0 2 2 2 1 Thioredoxin-like domain Thioredoxin_15 PF18403.1 ETO27493.1 - 0.0023 17.9 1.2 0.021 14.7 0.1 2.7 2 1 0 2 2 2 1 Thioredoxin-like domain DndE PF08870.11 ETO27493.1 - 0.034 14.4 0.6 7.7 6.8 0.1 3.5 3 0 0 3 3 3 0 DNA sulphur modification protein DndE iPGM_N PF06415.13 ETO27493.1 - 0.078 12.4 0.9 0.42 10.0 0.0 2.3 2 0 0 2 2 2 0 BPG-independent PGAM N-terminus (iPGM_N) SWIRM PF04433.17 ETO27497.1 - 0.087 13.2 0.8 0.19 12.1 0.8 1.5 1 0 0 1 1 1 0 SWIRM domain DUF3916 PF13079.6 ETO27498.1 - 0.0092 15.9 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3916) FAM219A PF15260.6 ETO27498.1 - 0.039 14.3 0.3 0.065 13.6 0.3 1.3 1 0 0 1 1 1 0 Protein family FAM219A Ion_trans PF00520.31 ETO27498.1 - 0.84 8.8 18.6 0.38 10.0 15.0 1.8 1 1 1 2 2 2 0 Ion transport protein PTH2 PF01981.16 ETO27500.1 - 2.7e-32 111.5 0.0 3.1e-32 111.3 0.0 1.0 1 0 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 BTHB PF18410.1 ETO27500.1 - 0.061 13.1 0.0 0.096 12.5 0.0 1.3 1 0 0 1 1 1 0 Basic tilted helix bundle domain TPR_1 PF00515.28 ETO27501.1 - 2.3e-12 46.2 12.2 2.6e-06 27.0 0.4 4.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27501.1 - 1.6e-10 40.5 3.6 1e-05 25.1 0.1 3.6 2 1 1 3 3 3 2 TPR repeat TPR_8 PF13181.6 ETO27501.1 - 2.8e-10 39.6 7.4 2.8e-05 24.0 0.1 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27501.1 - 1.7e-09 37.0 10.7 0.00015 21.7 0.2 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO27501.1 - 2e-08 34.4 2.5 4.1e-05 23.8 0.2 3.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO27501.1 - 6.2e-08 32.8 0.0 0.00093 19.8 0.0 3.7 3 1 1 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27501.1 - 3.5e-07 30.2 1.5 0.0031 17.8 0.2 4.1 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO27501.1 - 1.8e-06 28.5 0.0 0.0022 18.6 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO27501.1 - 5.4e-05 23.6 0.3 0.41 11.4 0.0 3.6 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO27501.1 - 5.4e-05 23.6 0.6 0.00093 19.7 0.1 2.9 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27501.1 - 0.00027 20.7 2.3 0.18 11.8 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO27501.1 - 0.0044 16.4 0.1 2.1 7.9 0.0 3.4 3 1 0 3 3 3 1 SHNi-TPR MIT PF04212.18 ETO27501.1 - 0.011 15.8 3.9 2.4 8.3 0.1 3.3 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_7 PF13176.6 ETO27501.1 - 0.018 15.0 2.0 1.5 9.0 0.0 3.5 3 1 1 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO27501.1 - 0.026 15.2 0.2 5.7 7.8 0.0 2.7 2 0 0 2 2 2 0 Sel1 repeat ANAPC3 PF12895.7 ETO27501.1 - 0.038 14.2 1.2 0.26 11.5 0.2 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5344 PF17279.2 ETO27501.1 - 0.041 14.4 5.1 3.3 8.3 0.1 3.2 3 0 0 3 3 3 0 Family of unknown function (DUF5344) RRM_1 PF00076.22 ETO27502.1 - 3.2e-13 49.3 0.4 4.7e-13 48.8 0.4 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO27502.1 - 0.00021 21.3 0.1 0.00032 20.8 0.0 1.4 1 1 0 1 1 1 1 RNA recognition motif DUF2207 PF09972.9 ETO27503.1 - 0.0091 14.8 0.0 0.012 14.4 0.0 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) PHP PF02811.19 ETO27503.1 - 0.037 14.3 0.0 0.07 13.4 0.0 1.4 1 0 0 1 1 1 0 PHP domain Shisa PF13908.6 ETO27503.1 - 0.067 13.4 0.0 0.079 13.2 0.0 1.3 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator ICAP-1_inte_bdg PF10480.9 ETO27503.1 - 0.12 12.3 0.1 0.2 11.6 0.1 1.3 1 0 0 1 1 1 0 Beta-1 integrin binding protein SAPS PF04499.15 ETO27504.1 - 0.00042 19.2 7.5 0.00057 18.8 7.5 1.2 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein LAP1C PF05609.12 ETO27504.1 - 0.23 10.5 7.3 0.31 10.1 7.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) NUDIX_2 PF13869.6 ETO27504.1 - 0.59 9.7 3.8 4.5 6.8 0.1 2.4 1 1 1 2 2 2 0 Nucleotide hydrolase DUF913 PF06025.12 ETO27504.1 - 0.8 8.6 5.9 1 8.2 5.9 1.4 1 1 0 1 1 1 0 Domain of Unknown Function (DUF913) Sec62 PF03839.16 ETO27504.1 - 2.5 7.5 5.1 4.1 6.9 5.1 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 BCL_N PF04714.13 ETO27505.1 - 0.0032 17.5 0.2 0.0097 16.0 0.2 1.9 1 0 0 1 1 1 1 BCL7, N-terminal conserver region Lactamase_B_2 PF12706.7 ETO27505.1 - 0.029 13.9 0.0 0.044 13.3 0.0 1.3 1 0 0 1 1 1 0 Beta-lactamase superfamily domain EF-hand_1 PF00036.32 ETO27506.1 - 2.8e-14 51.5 12.1 2.1e-06 26.8 4.0 3.6 3 1 0 3 3 3 2 EF hand EF-hand_7 PF13499.6 ETO27506.1 - 2.3e-12 47.2 3.4 2.3e-12 47.2 1.7 1.9 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO27506.1 - 1.2e-10 40.4 11.7 1.6e-06 27.5 0.1 4.0 3 2 2 5 5 5 2 EF-hand domain EF-hand_5 PF13202.6 ETO27506.1 - 2.3e-07 30.0 14.6 9.3e-05 21.8 0.1 4.2 3 2 1 4 4 4 2 EF hand EF-hand_8 PF13833.6 ETO27506.1 - 2.7e-07 30.3 6.9 5.1e-07 29.5 4.8 2.4 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_4 PF12763.7 ETO27506.1 - 4.4e-05 23.4 0.3 6.7e-05 22.8 0.3 1.3 1 0 0 1 1 1 1 Cytoskeletal-regulatory complex EF hand EF-hand_9 PF14658.6 ETO27506.1 - 0.00094 19.5 0.5 0.0018 18.5 0.1 1.7 2 0 0 2 2 2 1 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO27506.1 - 0.002 18.5 0.4 0.0029 17.9 0.4 1.4 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 ETO27506.1 - 0.0064 16.4 0.6 0.11 12.4 0.0 2.2 1 1 1 2 2 2 1 Caleosin related protein TerB PF05099.13 ETO27506.1 - 0.012 15.5 0.1 0.053 13.5 0.0 1.8 1 1 1 2 2 2 0 Tellurite resistance protein TerB EF-hand_14 PF17959.1 ETO27506.1 - 0.019 15.3 0.6 0.043 14.2 0.1 1.8 1 1 1 2 2 2 0 EF-hand domain YppG PF14179.6 ETO27506.1 - 3 8.6 6.2 9.7 7.0 0.5 2.3 2 1 0 2 2 2 0 YppG-like protein EamA PF00892.20 ETO27507.1 - 0.00054 20.1 3.3 0.0073 16.5 0.3 2.1 2 0 0 2 2 2 1 EamA-like transporter family SR-25 PF10500.9 ETO27507.1 - 0.011 15.4 22.2 0.011 15.4 22.2 2.1 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Fanconi_A PF03511.14 ETO27507.1 - 0.05 13.5 0.1 0.11 12.5 0.1 1.6 1 0 0 1 1 1 0 Fanconi anaemia group A protein SID-1_RNA_chan PF13965.6 ETO27507.1 - 0.16 10.4 2.6 0.22 9.9 2.6 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 LMBR1 PF04791.16 ETO27507.1 - 0.35 9.7 3.7 0.42 9.5 3.7 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-C_mid PF15620.6 ETO27507.1 - 1.6 8.6 28.9 2.1 8.3 28.9 1.1 1 0 0 1 1 1 0 Centromere assembly component CENP-C middle DNMT3B-binding region Sec62 PF03839.16 ETO27507.1 - 5.8 6.4 19.5 11 5.4 19.5 1.4 1 1 0 1 1 1 0 Translocation protein Sec62 SpoIIIAH PF12685.7 ETO27507.1 - 9.1 6.0 20.2 32 4.2 20.2 1.8 1 1 0 1 1 1 0 SpoIIIAH-like protein FNIP PF05725.12 ETO27508.1 - 0.0083 16.3 0.2 2.4 8.4 0.0 3.3 2 1 0 2 2 2 2 FNIP Repeat Pox_Ag35 PF03286.14 ETO27508.1 - 0.33 10.7 2.7 0.56 10.0 2.7 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Herpes_UL74 PF07982.12 ETO27509.1 - 0.025 13.5 1.7 0.035 13.1 1.7 1.1 1 0 0 1 1 1 0 Herpes UL74 glycoproteins APO_RNA-bind PF05634.11 ETO27509.1 - 0.039 13.3 0.1 0.079 12.3 0.1 1.5 1 0 0 1 1 1 0 APO RNA-binding Ras PF00071.22 ETO27510.1 - 7.3e-21 74.4 0.1 3.4e-20 72.3 0.1 1.9 1 1 0 1 1 1 1 Ras family PUB PF09409.10 ETO27511.1 - 1e-06 28.6 0.9 3.1e-06 27.0 0.1 2.2 3 0 0 3 3 3 1 PUB domain WW PF00397.26 ETO27511.1 - 0.013 15.6 0.0 0.013 15.6 0.0 2.0 2 0 0 2 2 2 0 WW domain ABC2_membrane_3 PF12698.7 ETO27513.1 - 5e-22 78.5 15.4 8.5e-22 77.7 15.4 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ETO27513.1 - 1.2e-19 71.2 0.0 3.2e-19 69.8 0.0 1.7 1 1 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ETO27513.1 - 0.023 15.2 0.2 0.04 14.4 0.2 1.3 1 0 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO27513.1 - 0.047 13.4 0.8 0.15 11.8 0.1 2.2 2 0 0 2 2 2 0 P-loop containing region of AAA domain Pox_Ag35 PF03286.14 ETO27514.1 - 0.0044 16.8 9.5 0.0065 16.3 9.5 1.2 1 0 0 1 1 1 1 Pox virus Ag35 surface protein Tim54 PF11711.8 ETO27514.1 - 0.005 15.7 8.8 0.0069 15.2 8.8 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO27514.1 - 0.0052 16.0 0.7 0.0066 15.7 0.7 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter Hid1 PF12722.7 ETO27514.1 - 0.0055 14.9 7.3 0.0067 14.6 7.3 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein DDHD PF02862.17 ETO27514.1 - 0.0089 16.2 2.5 0.012 15.8 2.5 1.2 1 0 0 1 1 1 1 DDHD domain SLC12 PF03522.15 ETO27514.1 - 0.018 14.1 2.7 0.023 13.8 2.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF2052 PF09747.9 ETO27514.1 - 0.02 15.0 11.2 0.027 14.6 11.2 1.2 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Peptidase_S49_N PF08496.10 ETO27514.1 - 0.052 13.6 4.5 0.093 12.8 4.5 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal RR_TM4-6 PF06459.12 ETO27514.1 - 0.055 13.3 8.8 0.067 13.0 8.8 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 H_lectin PF09458.10 ETO27514.1 - 0.058 13.6 0.0 0.13 12.4 0.0 1.6 1 0 0 1 1 1 0 H-type lectin domain BSP_II PF05432.11 ETO27514.1 - 0.092 12.4 16.1 0.12 12.0 16.1 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) FAM176 PF14851.6 ETO27514.1 - 0.12 12.0 8.8 0.21 11.2 8.8 1.4 1 0 0 1 1 1 0 FAM176 family DUF4820 PF16091.5 ETO27514.1 - 0.14 11.5 6.6 0.21 10.9 6.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Cytomega_UL84 PF06284.11 ETO27514.1 - 0.18 10.3 2.6 0.24 9.8 2.6 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein AIM3 PF17096.5 ETO27514.1 - 0.25 12.3 5.7 0.5 11.3 5.7 1.5 1 0 0 1 1 1 0 Altered inheritance of mitochondria protein 3 BNIP3 PF06553.12 ETO27514.1 - 0.26 10.9 10.4 0.63 9.7 10.4 1.6 1 1 0 1 1 1 0 BNIP3 Vfa1 PF08432.10 ETO27514.1 - 0.29 11.4 12.0 0.43 10.9 12.0 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RCC1_2 PF13540.6 ETO27514.1 - 0.34 10.8 1.1 0.6 10.0 0.1 2.0 2 0 0 2 2 2 0 Regulator of chromosome condensation (RCC1) repeat ALMT PF11744.8 ETO27514.1 - 0.34 9.7 7.1 0.44 9.3 7.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF913 PF06025.12 ETO27514.1 - 0.44 9.5 6.1 0.58 9.1 6.1 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) TRAP_alpha PF03896.16 ETO27514.1 - 0.45 9.7 10.1 0.68 9.1 10.1 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RPN2_C PF18004.1 ETO27514.1 - 0.45 10.4 13.2 0.67 9.9 13.2 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Connexin PF00029.19 ETO27514.1 - 0.56 9.9 5.8 0.94 9.2 5.8 1.3 1 0 0 1 1 1 0 Connexin Nop14 PF04147.12 ETO27514.1 - 0.58 8.3 15.4 0.73 8.0 15.4 1.1 1 0 0 1 1 1 0 Nop14-like family PA26 PF04636.13 ETO27514.1 - 0.6 9.0 8.5 0.79 8.6 8.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Presenilin PF01080.17 ETO27514.1 - 0.63 8.7 8.9 1.1 8.0 8.9 1.4 1 0 0 1 1 1 0 Presenilin COPI_C PF06957.11 ETO27514.1 - 0.69 8.6 6.7 0.98 8.1 6.7 1.2 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus RNA_polI_A34 PF08208.11 ETO27514.1 - 1.4 9.0 13.7 1.9 8.5 13.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3292 PF11696.8 ETO27514.1 - 1.4 7.2 8.4 2.1 6.6 8.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) CPSF100_C PF13299.6 ETO27514.1 - 1.4 9.0 8.2 2.2 8.4 8.2 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4746 PF15928.5 ETO27514.1 - 1.5 8.2 13.6 2.1 7.7 13.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) EIIBC-GUT_N PF03612.14 ETO27514.1 - 1.6 8.5 5.8 2.6 7.7 5.8 1.4 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF3408 PF11888.8 ETO27514.1 - 1.7 8.7 13.3 3.2 7.9 13.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) CobT PF06213.12 ETO27514.1 - 2.5 7.4 16.2 3.5 7.0 16.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Paf1 PF03985.13 ETO27514.1 - 3.1 6.7 17.5 4.1 6.3 17.5 1.1 1 0 0 1 1 1 0 Paf1 Roughex PF06020.11 ETO27514.1 - 5.7 5.9 10.0 7.7 5.5 10.0 1.1 1 0 0 1 1 1 0 Drosophila roughex protein CDC45 PF02724.14 ETO27514.1 - 5.9 5.1 14.7 9.7 4.3 14.7 1.3 1 1 0 1 1 1 0 CDC45-like protein Atrophin-1 PF03154.15 ETO27514.1 - 6.2 5.0 8.2 8.8 4.5 8.2 1.2 1 0 0 1 1 1 0 Atrophin-1 family NOA36 PF06524.12 ETO27514.1 - 6.4 6.0 15.9 8.9 5.5 15.9 1.1 1 0 0 1 1 1 0 NOA36 protein PBP_sp32 PF07222.12 ETO27514.1 - 9.1 5.6 13.4 13 5.1 13.4 1.2 1 0 0 1 1 1 0 Proacrosin binding protein sp32 ABC2_membrane_3 PF12698.7 ETO27515.1 - 5.2e-22 78.4 21.1 1.3e-21 77.2 21.1 1.6 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ETO27515.1 - 9.9e-15 55.3 0.0 2.8e-14 53.8 0.0 1.7 1 0 0 1 1 1 1 ABC transporter DUF1772 PF08592.11 ETO27515.1 - 1 9.7 5.8 1.2 9.4 4.2 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1772) DUF4162 PF13732.6 ETO27516.1 - 0.02 15.6 0.1 0.19 12.5 0.1 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4162) DUF5511 PF17630.2 ETO27516.1 - 0.081 13.1 0.0 0.2 11.9 0.0 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5511) HLH PF00010.26 ETO27516.1 - 0.14 12.1 0.0 0.26 11.3 0.0 1.4 1 0 0 1 1 1 0 Helix-loop-helix DNA-binding domain Consortin_C PF15281.6 ETO27517.1 - 0.013 15.5 0.1 0.038 14.0 0.0 1.9 2 0 0 2 2 2 0 Consortin C-terminus HCO3_cotransp PF00955.21 ETO27517.1 - 0.015 14.1 1.0 0.028 13.2 1.0 1.4 1 0 0 1 1 1 0 HCO3- transporter family Otopetrin PF03189.13 ETO27517.1 - 0.024 13.5 0.0 0.047 12.5 0.0 1.7 1 1 0 1 1 1 0 Otopetrin DUF4611 PF15387.6 ETO27517.1 - 0.033 14.4 1.2 0.033 14.4 1.2 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4611) DUF3402 PF11882.8 ETO27517.1 - 0.061 12.4 0.0 0.061 12.4 0.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3402) BSMAP PF12280.8 ETO27517.1 - 0.11 12.6 0.0 0.11 12.6 0.0 2.0 2 1 0 2 2 2 0 Brain specific membrane anchored protein PilI PF10623.9 ETO27518.1 - 0.017 15.3 0.0 0.05 13.8 0.0 1.8 1 0 0 1 1 1 0 Plasmid conjugative transfer protein PilI VWD PF00094.25 ETO27519.1 - 0.094 13.0 0.5 0.23 11.7 0.2 1.7 1 1 1 2 2 2 0 von Willebrand factor type D domain Ras PF00071.22 ETO27520.1 - 1.9e-11 43.8 0.0 4.5e-06 26.4 0.0 3.4 3 1 0 3 3 3 3 Ras family Roc PF08477.13 ETO27520.1 - 1.2e-07 31.9 0.4 5.3e-05 23.4 0.1 2.7 1 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO27520.1 - 0.027 13.9 0.0 0.07 12.6 0.0 1.6 2 0 0 2 2 2 0 ADP-ribosylation factor family RabGAP-TBC PF00566.18 ETO27521.1 - 1.1e-31 110.1 2.7 1.1e-31 110.1 2.7 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain RNA_pol_Rpc4 PF05132.14 ETO27521.1 - 0.011 16.1 0.3 0.013 15.9 0.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 CSRNP_N PF16019.5 ETO27521.1 - 0.075 12.9 9.1 0.11 12.4 9.1 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus Serinc PF03348.15 ETO27521.1 - 0.2 10.6 4.9 0.26 10.2 4.9 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SID-1_RNA_chan PF13965.6 ETO27521.1 - 0.29 9.5 0.8 0.29 9.5 0.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 NPR3 PF03666.13 ETO27521.1 - 0.29 9.9 11.6 0.4 9.4 11.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4820 PF16091.5 ETO27521.1 - 0.5 9.7 9.0 0.78 9.1 9.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DDHD PF02862.17 ETO27521.1 - 0.58 10.3 6.3 0.78 9.9 6.3 1.2 1 0 0 1 1 1 0 DDHD domain CPSF100_C PF13299.6 ETO27521.1 - 0.67 10.1 8.5 1.1 9.4 8.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RP-C_C PF11800.8 ETO27521.1 - 0.68 10.0 8.3 0.93 9.5 8.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region SLC12 PF03522.15 ETO27521.1 - 0.9 8.5 12.2 1.1 8.2 12.2 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Gti1_Pac2 PF09729.9 ETO27521.1 - 1.6 8.8 11.5 2.4 8.2 11.5 1.3 1 0 0 1 1 1 0 Gti1/Pac2 family RPN2_C PF18004.1 ETO27521.1 - 2 8.3 16.0 3.5 7.5 16.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain ALMT PF11744.8 ETO27521.1 - 2.6 6.8 10.2 3.1 6.5 10.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter BT1 PF03092.16 ETO27521.1 - 2.8 6.1 4.7 20 3.3 0.0 2.0 2 0 0 2 2 2 0 BT1 family Presenilin PF01080.17 ETO27521.1 - 2.8 6.6 12.0 3.7 6.2 12.0 1.1 1 0 0 1 1 1 0 Presenilin RPA43_OB PF17875.1 ETO27521.1 - 2.9 8.5 12.2 6.5 7.4 12.2 1.6 1 1 0 1 1 1 0 RPA43 OB domain in RNA Pol I CLN3 PF02487.17 ETO27521.1 - 4.3 6.3 4.7 5.5 5.9 4.7 1.1 1 0 0 1 1 1 0 CLN3 protein FAM60A PF15396.6 ETO27521.1 - 5.2 7.0 10.8 7.2 6.6 10.8 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Zip PF02535.22 ETO27521.1 - 6.9 5.8 9.0 8.8 5.4 9.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Cellulose_synt PF03552.14 ETO27521.1 - 7.1 5.0 6.7 9.6 4.6 6.7 1.1 1 0 0 1 1 1 0 Cellulose synthase WD40 PF00400.32 ETO27522.1 - 9.3e-22 76.9 10.5 6.9e-07 29.9 0.0 6.4 5 1 1 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27522.1 - 4.6e-12 46.1 0.3 0.021 15.1 0.0 4.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO27522.1 - 8.1e-08 32.4 1.2 2.2e-06 27.7 0.1 2.5 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO27522.1 - 0.018 13.6 0.0 0.043 12.3 0.0 1.6 1 1 0 1 1 1 0 Cytochrome D1 heme domain CDC45 PF02724.14 ETO27522.1 - 0.093 11.0 11.6 0.16 10.2 11.6 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 ETO27522.1 - 0.5 9.7 17.3 0.7 9.2 17.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SprA-related PF12118.8 ETO27522.1 - 0.92 8.6 33.3 0.93 8.6 31.9 1.7 2 0 0 2 2 2 0 SprA-related family Ndc1_Nup PF09531.10 ETO27522.1 - 1.3 7.6 14.2 1.8 7.1 14.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Suf PF05843.14 ETO27522.1 - 2 8.3 23.8 3.6 7.5 23.8 1.4 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 ETO27522.1 - 2.9 6.6 23.3 4.3 6.0 23.3 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO27522.1 - 3.7 7.3 17.9 7.1 6.4 17.9 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 LAP1C PF05609.12 ETO27522.1 - 5.1 6.1 25.3 9.1 5.2 25.3 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RSS_P20 PF11757.8 ETO27525.1 - 0.87 10.1 9.9 4.1 7.9 0.0 4.5 3 2 1 4 4 4 0 Suppressor of RNA silencing P21-like N-terminal domain Vma12 PF11712.8 ETO27526.1 - 0.0042 17.2 2.1 0.0062 16.6 2.1 1.5 1 1 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase Glutaminase PF04960.15 ETO27526.1 - 0.23 10.6 1.1 1.3 8.2 0.3 2.1 2 0 0 2 2 2 0 Glutaminase SpoVR PF04293.13 ETO27527.1 - 0.041 12.6 3.4 0.046 12.4 2.5 1.4 1 1 0 1 1 1 0 SpoVR like protein Wx5_PLAF3D7 PF09688.10 ETO27527.1 - 0.057 13.4 2.4 0.27 11.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (Wx5_PLAF3D7) Period_C PF12114.8 ETO27527.1 - 0.12 11.9 1.1 0.29 10.7 1.1 1.6 1 0 0 1 1 1 0 Period protein 2/3C-terminal region WD40 PF00400.32 ETO27529.1 - 2.8e-15 56.4 2.4 7.9e-06 26.5 0.9 3.8 3 2 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO27529.1 - 0.0053 15.5 0.8 0.31 9.6 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF840 PF05801.11 ETO27529.1 - 0.035 14.2 1.5 3.4 7.8 0.1 2.1 1 1 1 2 2 2 0 Lagovirus protein of unknown function (DUF840) ANAPC4_WD40 PF12894.7 ETO27529.1 - 0.076 13.3 0.1 7.8 6.9 0.0 2.7 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain RNA_pol_Rpc4 PF05132.14 ETO27530.1 - 0.33 11.4 3.3 0.91 9.9 0.4 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Med19 PF10278.9 ETO27530.1 - 1.2 9.1 7.6 2.6 7.9 7.6 1.5 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Pkinase PF00069.25 ETO27531.1 - 5.5e-62 209.5 0.0 1.8e-61 207.9 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27531.1 - 4.7e-30 104.7 0.0 8.6e-30 103.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO27531.1 - 2e-20 70.7 19.4 3.4e-05 23.1 0.1 5.7 5 0 0 5 5 4 4 EF hand EF-hand_7 PF13499.6 ETO27531.1 - 4.7e-20 71.8 10.6 4e-11 43.2 1.2 4.1 3 1 1 4 4 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO27531.1 - 1e-16 59.3 12.5 3e-05 23.6 0.2 5.5 5 0 0 5 5 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO27531.1 - 2.2e-15 55.3 8.4 5.2e-05 22.5 0.1 5.0 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO27531.1 - 4.7e-15 55.2 8.9 0.0001 22.1 0.5 5.2 3 1 2 5 5 5 4 EF-hand domain pair EF-hand_4 PF12763.7 ETO27531.1 - 0.00029 20.7 0.2 0.25 11.3 0.3 3.0 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand APH PF01636.23 ETO27531.1 - 0.00056 19.9 0.0 0.12 12.3 0.0 2.4 1 1 1 2 2 2 2 Phosphotransferase enzyme family EFhand_Ca_insen PF08726.10 ETO27531.1 - 0.0015 18.6 0.1 0.21 11.7 0.2 2.7 2 0 0 2 2 2 1 Ca2+ insensitive EF hand Kdo PF06293.14 ETO27531.1 - 0.023 14.0 0.3 0.087 12.2 0.0 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family CDC45 PF02724.14 ETO27531.1 - 0.12 10.7 11.0 0.2 9.9 11.0 1.4 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO27531.1 - 2.4 7.3 9.8 4.4 6.4 9.8 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter MCM_bind PF09739.9 ETO27531.1 - 3.9 5.8 16.5 5.1 5.4 15.7 1.6 2 0 0 2 2 2 0 Mini-chromosome maintenance replisome factor ASC PF00858.24 ETO27531.1 - 5.8 5.8 13.7 0.45 9.4 8.2 1.9 2 0 0 2 2 2 0 Amiloride-sensitive sodium channel Presenilin PF01080.17 ETO27531.1 - 8.3 5.1 15.5 14 4.3 15.5 1.3 1 0 0 1 1 1 0 Presenilin RGS PF00615.19 ETO27532.1 - 5e-09 36.5 2.0 8.8e-09 35.7 2.0 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain MFS_1 PF07690.16 ETO27532.1 - 0.00039 19.4 3.1 0.00056 18.9 3.1 1.1 1 0 0 1 1 1 1 Major Facilitator Superfamily TMEM154 PF15102.6 ETO27533.1 - 0.0028 17.6 3.6 0.0029 17.5 1.0 2.1 2 0 0 2 2 2 1 TMEM154 protein family Adeno_E3_CR2 PF02439.15 ETO27533.1 - 0.011 15.5 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Dicty_REP PF05086.12 ETO27533.1 - 0.016 13.2 2.4 0.02 12.9 2.4 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Glycophorin_A PF01102.18 ETO27533.1 - 0.021 15.0 0.8 0.054 13.7 0.2 1.9 2 0 0 2 2 2 0 Glycophorin A Rax2 PF12768.7 ETO27533.1 - 0.022 14.2 0.1 0.038 13.4 0.1 1.3 1 0 0 1 1 1 0 Cortical protein marker for cell polarity Mid2 PF04478.12 ETO27533.1 - 0.03 14.1 0.8 0.051 13.4 0.8 1.5 1 0 0 1 1 1 0 Mid2 like cell wall stress sensor Tankyrase_bdg_C PF15327.6 ETO27533.1 - 0.13 12.7 0.1 0.13 12.7 0.1 1.9 3 0 0 3 3 3 0 Tankyrase binding protein C terminal domain PRIMA1 PF16101.5 ETO27533.1 - 0.41 10.7 3.3 6.1 6.9 0.5 2.8 3 0 0 3 3 3 0 Proline-rich membrane anchor 1 JAB PF01398.21 ETO27534.1 - 0.00099 19.1 1.4 0.0023 17.9 0.1 2.3 3 0 0 3 3 3 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease TetR_C_5 PF08360.11 ETO27534.1 - 0.069 13.3 0.2 0.15 12.3 0.2 1.5 1 0 0 1 1 1 0 QacR-like protein, C-terminal region Sulfotransfer_2 PF03567.14 ETO27535.1 - 2.2e-08 34.3 15.1 6.2e-05 23.0 8.2 2.4 1 1 1 2 2 2 2 Sulfotransferase family Zip PF02535.22 ETO27536.1 - 0.01 15.1 0.2 0.012 14.8 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter NOA36 PF06524.12 ETO27536.1 - 2.5 7.3 12.1 3.3 7.0 12.1 1.1 1 0 0 1 1 1 0 NOA36 protein HMA PF00403.26 ETO27537.1 - 1.4e-09 38.3 5.6 0.0001 22.7 0.1 3.3 3 0 0 3 3 3 3 Heavy-metal-associated domain DUF3212 PF11486.8 ETO27537.1 - 0.059 13.4 0.7 3.8 7.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3212) VATC PF18716.1 ETO27537.1 - 7.8 6.4 6.2 2.1 8.2 0.3 2.3 2 0 0 2 2 2 0 Vms1-associating treble clef domain Sigma70_ner PF04546.13 ETO27538.1 - 1.1 9.0 16.7 0.22 11.4 2.0 2.3 2 0 0 2 2 2 0 Sigma-70, non-essential region DUF3438 PF11920.8 ETO27538.1 - 5.5 6.1 5.8 0.41 9.8 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3438) Fzo_mitofusin PF04799.13 ETO27538.1 - 8.2 6.0 9.8 3.4 7.2 2.8 2.5 2 1 1 3 3 3 0 fzo-like conserved region Trimer_CC PF08954.11 ETO27539.1 - 0.056 13.0 0.9 0.13 11.8 0.9 1.7 1 0 0 1 1 1 0 Trimerisation motif DUF4094 PF13334.6 ETO27539.1 - 0.16 12.4 1.8 0.47 10.9 1.8 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4094) WD40 PF00400.32 ETO27540.1 - 1.1e-60 200.1 12.3 5.6e-10 39.6 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27540.1 - 3e-19 69.1 5.2 0.047 14.0 0.0 6.5 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27540.1 - 8.6e-16 57.8 0.6 0.058 12.3 0.0 5.7 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27540.1 - 6.2e-09 35.6 3.1 0.0015 17.9 0.0 4.4 2 1 3 5 5 5 2 WD40-like domain Nup160 PF11715.8 ETO27540.1 - 3.6e-08 32.5 2.7 0.76 8.4 0.0 5.2 2 2 3 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO27540.1 - 1.1e-06 28.4 3.1 5.5 7.0 0.0 5.7 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO27540.1 - 1.6e-05 25.0 1.1 13 5.9 0.0 5.7 1 1 5 6 6 6 0 Family of unknown function (DUF5570) DUF727 PF05303.12 ETO27540.1 - 0.00018 21.5 0.2 0.26 11.3 0.0 3.8 2 2 0 3 3 3 1 Protein of unknown function (DUF727) Nbas_N PF15492.6 ETO27540.1 - 0.00028 20.3 2.4 4.9 6.4 0.0 4.6 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO27540.1 - 0.00029 19.5 0.2 0.32 9.5 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain HARP PF07443.13 ETO27540.1 - 0.00094 18.8 0.2 1.8 8.3 0.0 4.0 5 0 0 5 5 5 1 HepA-related protein (HARP) Nucleoporin_N PF08801.11 ETO27540.1 - 0.0063 15.3 2.2 1.2 7.8 0.2 3.2 1 1 2 3 3 3 2 Nup133 N terminal like DUF1797 PF08796.10 ETO27540.1 - 0.029 14.5 0.0 18 5.5 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) Proteasome_A_N PF10584.9 ETO27540.1 - 0.092 12.5 4.6 64 3.4 0.0 4.8 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Ferritin PF00210.24 ETO27541.1 - 0.0022 17.9 0.2 0.0054 16.7 0.2 1.6 1 0 0 1 1 1 1 Ferritin-like domain TIG_2 PF18020.1 ETO27541.1 - 0.025 15.2 0.2 0.08 13.6 0.2 2.0 1 1 0 1 1 1 0 TIG domain found in plexin FlgT_N PF16548.5 ETO27541.1 - 7.6 7.2 7.0 9.5 6.9 0.3 2.8 3 0 0 3 3 3 0 Flagellar assembly protein T, N-terminal domain SBF_like PF13593.6 ETO27542.1 - 0.0026 17.2 0.6 0.0026 17.2 0.6 1.7 2 0 0 2 2 2 1 SBF-like CPA transporter family (DUF4137) CK_II_beta PF01214.18 ETO27543.1 - 2.7e-13 50.1 0.8 5.8e-13 49.1 0.3 1.7 2 0 0 2 2 2 1 Casein kinase II regulatory subunit Med11 PF10280.9 ETO27544.1 - 0.017 15.6 12.2 0.12 12.9 3.8 2.8 1 1 1 2 2 2 0 Mediator complex protein Com_YlbF PF06133.11 ETO27544.1 - 0.026 15.1 5.4 0.026 15.1 5.4 5.1 1 1 4 5 5 5 0 Control of competence regulator ComK, YlbF/YmcA GAS PF13851.6 ETO27544.1 - 0.042 13.2 53.5 1.1 8.5 8.5 3.3 1 1 2 3 3 3 0 Growth-arrest specific micro-tubule binding CALCOCO1 PF07888.11 ETO27544.1 - 0.84 8.4 41.8 0.066 12.1 31.2 2.0 1 1 1 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like DASH_Dad1 PF08649.10 ETO27544.1 - 1.7 8.9 20.2 0.18 12.0 0.5 4.4 6 0 0 6 6 6 0 DASH complex subunit Dad1 HBM PF16591.5 ETO27544.1 - 2 7.8 27.3 6.3 6.2 8.0 3.2 1 1 1 2 2 2 0 Helical bimodular sensor domain DUF3584 PF12128.8 ETO27544.1 - 2 5.8 37.8 4.8 4.6 37.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) DUF948 PF06103.11 ETO27544.1 - 5.2 7.4 16.9 1 9.7 0.3 4.4 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) dsrm PF00035.26 ETO27545.1 - 1.9e-07 31.7 0.1 2.6e-07 31.2 0.1 1.2 1 0 0 1 1 1 1 Double-stranded RNA binding motif Ufd2P_core PF10408.9 ETO27546.1 - 9.2e-68 229.4 9.1 1.1e-67 229.0 9.1 1.0 1 0 0 1 1 1 1 Ubiquitin elongating factor core Ufd2P_core PF10408.9 ETO27547.1 - 1.1e-20 73.9 0.6 1.3e-20 73.6 0.6 1.2 1 0 0 1 1 1 1 Ubiquitin elongating factor core Mis12 PF05859.12 ETO27549.1 - 0.011 15.7 0.2 0.015 15.3 0.2 1.2 1 0 0 1 1 1 0 Mis12 protein Zip PF02535.22 ETO27549.1 - 0.022 14.0 1.8 0.021 14.1 1.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO27549.1 - 8.7 5.0 6.9 9.5 4.9 6.9 1.1 1 0 0 1 1 1 0 Presenilin S1 PF00575.23 ETO27550.1 - 2.5e-08 34.2 0.6 0.002 18.4 0.0 4.0 4 0 0 4 4 4 2 S1 RNA binding domain Innexin PF00876.18 ETO27550.1 - 0.002 17.5 1.7 0.0023 17.3 0.0 1.9 2 1 0 2 2 2 1 Innexin BSP_II PF05432.11 ETO27550.1 - 0.0072 16.1 15.8 0.0072 16.1 15.8 2.2 2 0 0 2 2 2 1 Bone sialoprotein II (BSP-II) CPSF100_C PF13299.6 ETO27550.1 - 0.49 10.6 11.4 0.47 10.6 2.9 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal HNOBA PF07701.14 ETO27550.1 - 1 8.7 5.2 8.6 5.7 1.9 2.5 2 0 0 2 2 2 0 Heme NO binding associated DUF913 PF06025.12 ETO27550.1 - 1.5 7.7 6.1 3.9 6.4 1.9 2.2 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) TLP-20 PF06088.11 ETO27550.1 - 1.7 8.5 15.9 0.31 10.9 2.6 2.5 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) NPR3 PF03666.13 ETO27550.1 - 2.2 7.0 16.1 0.52 9.0 4.9 2.3 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIIAH PF12685.7 ETO27550.1 - 2.4 7.9 17.8 3.7 7.3 6.4 2.4 2 0 0 2 2 2 0 SpoIIIAH-like protein Connexin PF00029.19 ETO27550.1 - 4.1 7.1 8.5 2.7 7.7 3.3 2.5 2 0 0 2 2 2 0 Connexin S1 PF00575.23 ETO27551.1 - 0.0016 18.8 0.9 0.013 15.8 1.1 2.5 1 1 1 2 2 2 1 S1 RNA binding domain CDC45 PF02724.14 ETO27551.1 - 0.66 8.2 10.9 0.89 7.8 10.9 1.3 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO27551.1 - 8.8 5.6 24.4 14 4.8 24.4 1.3 1 0 0 1 1 1 0 BUD22 Suf PF05843.14 ETO27552.1 - 0.00031 20.8 0.7 0.039 13.9 0.2 2.1 1 1 1 2 2 2 2 Suppressor of forked protein (Suf) Glyco_hydro_18 PF00704.28 ETO27553.1 - 5.4e-14 52.6 1.0 6.1e-14 52.5 1.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 TPR_1 PF00515.28 ETO27554.1 - 3.5e-25 86.7 13.2 8.6e-05 22.2 0.7 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27554.1 - 6.1e-22 75.9 10.3 1.1e-05 25.1 0.1 6.7 6 0 0 6 6 6 4 Tetratricopeptide repeat STI1 PF17830.1 ETO27554.1 - 1.8e-19 69.4 7.0 2.7e-12 46.4 2.4 2.6 2 0 0 2 2 2 2 STI1 domain TPR_11 PF13414.6 ETO27554.1 - 2.5e-14 52.7 5.0 1.1e-08 34.6 0.3 4.9 4 1 1 5 5 5 2 TPR repeat TPR_12 PF13424.6 ETO27554.1 - 4e-14 52.7 0.6 8.2e-05 22.8 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27554.1 - 4.4e-10 39.0 12.8 0.0076 16.4 0.5 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27554.1 - 7e-09 35.5 6.7 0.0058 16.9 0.1 5.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO27554.1 - 1.5e-06 28.5 0.1 0.27 12.1 0.0 5.0 5 1 1 6 6 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO27554.1 - 1.8e-06 28.4 0.1 7.9e-05 23.2 0.0 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27554.1 - 6.3e-06 25.9 2.9 0.13 12.3 0.0 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat SDA1 PF05285.12 ETO27554.1 - 0.00016 21.2 20.2 0.00016 21.2 20.2 2.0 2 0 0 2 2 2 1 SDA1 TPR_6 PF13174.6 ETO27554.1 - 0.00021 21.7 4.1 0.24 12.1 0.1 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO27554.1 - 0.00041 20.5 0.0 0.0066 16.6 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27554.1 - 0.0014 18.4 8.7 1.5 8.8 0.1 4.9 5 0 0 5 5 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO27554.1 - 0.0028 17.7 1.1 0.52 10.4 0.0 3.5 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETO27554.1 - 0.0085 16.6 2.3 0.12 12.9 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat Striatin PF08232.12 ETO27554.1 - 0.017 15.8 1.2 0.017 15.8 1.2 3.2 2 1 1 3 3 2 0 Striatin family WTF PF03303.13 ETO27554.1 - 0.023 14.4 0.0 0.055 13.2 0.0 1.7 1 0 0 1 1 1 0 WTF protein Sel1 PF08238.12 ETO27554.1 - 0.13 13.0 0.1 4.2 8.2 0.0 2.8 2 0 0 2 2 2 0 Sel1 repeat RPN7 PF10602.9 ETO27554.1 - 0.23 11.2 11.6 0.04 13.6 3.4 2.8 2 0 0 2 2 2 0 26S proteasome subunit RPN7 BT1 PF03092.16 ETO27554.1 - 0.88 7.7 2.3 1.5 6.9 2.3 1.3 1 0 0 1 1 1 0 BT1 family Thioredoxin_6 PF13848.6 ETO27555.1 - 2.9e-10 40.4 8.9 1.1e-06 28.8 0.2 4.2 3 2 1 4 4 4 2 Thioredoxin-like domain OST3_OST6 PF04756.13 ETO27555.1 - 1.8e-06 27.5 1.7 5.6e-05 22.6 0.0 3.0 2 1 1 3 3 3 1 OST3 / OST6 family, transporter family DUF3719 PF12516.8 ETO27555.1 - 0.019 14.7 0.0 2 8.2 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3719) Ndc1_Nup PF09531.10 ETO27556.1 - 3.9 6.0 10.6 4.6 5.8 10.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CHAT PF12770.7 ETO27557.1 - 8.3e-09 35.3 0.2 1.5e-08 34.4 0.2 1.5 1 0 0 1 1 1 1 CHAT domain Kelch_6 PF13964.6 ETO27558.1 - 2.2e-09 37.3 10.0 5.4e-06 26.5 0.4 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO27558.1 - 2.6e-08 33.7 1.1 7.7e-05 22.6 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO27558.1 - 1.1e-05 24.8 15.6 0.0081 15.7 0.1 5.4 6 1 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ETO27558.1 - 0.00079 19.7 0.0 0.48 10.8 0.0 3.1 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO27558.1 - 0.05 13.6 8.4 1.8 8.7 0.2 4.3 5 0 0 5 5 5 0 Kelch motif Kelch_5 PF13854.6 ETO27558.1 - 0.22 11.6 2.7 0.62 10.1 0.7 2.8 3 0 0 3 3 3 0 Kelch motif GF_recep_IV PF14843.6 ETO27558.1 - 0.9 9.3 7.9 0.035 13.9 1.9 1.6 2 0 0 2 2 2 0 Growth factor receptor domain IV MAPEG PF01124.18 ETO27559.1 - 4.2e-16 59.0 0.0 7e-16 58.3 0.0 1.3 1 1 0 1 1 1 1 MAPEG family WD40 PF00400.32 ETO27560.1 - 1.6e-66 218.6 21.3 1.3e-11 44.8 0.5 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27560.1 - 7.7e-25 87.0 0.5 0.00028 21.1 0.0 5.4 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27560.1 - 2.3e-12 46.5 0.6 0.2 10.6 0.0 5.9 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27560.1 - 4.7e-11 42.6 5.0 3e-05 23.5 0.3 3.8 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO27560.1 - 1.3e-08 34.0 2.6 0.34 9.5 0.0 5.0 1 1 2 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO27560.1 - 3.9e-08 33.0 6.6 0.7 9.9 0.0 7.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO27560.1 - 7e-06 24.8 0.2 0.02 13.5 0.0 3.0 2 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO27560.1 - 7.6e-05 22.8 1.5 22 5.2 0.1 5.1 2 2 3 5 5 5 0 Family of unknown function (DUF5570) SGL PF08450.12 ETO27560.1 - 0.0016 18.1 0.9 2.1 7.9 0.1 3.5 1 1 2 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Proteasome_A_N PF10584.9 ETO27560.1 - 0.35 10.6 6.9 8.1 6.2 0.0 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature SOG2 PF10428.9 ETO27562.1 - 0.093 11.9 7.7 0.099 11.8 7.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SSP160 PF06933.11 ETO27562.1 - 0.26 9.4 11.0 0.32 9.1 11.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 ETO27562.1 - 1.7 6.7 8.0 2 6.4 8.0 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Mucin PF01456.17 ETO27562.1 - 1.7 8.6 21.1 2.5 8.1 21.1 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein MGC-24 PF05283.11 ETO27562.1 - 7.5 7.0 11.8 10 6.6 11.8 1.3 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin Mrr_N PF14338.6 ETO27567.1 - 0.0014 18.7 0.1 0.16 12.1 0.0 2.5 2 0 0 2 2 2 1 Mrr N-terminal domain DUF2207 PF09972.9 ETO27567.1 - 0.026 13.3 0.0 0.035 12.9 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF5383 PF17355.2 ETO27567.1 - 0.028 14.8 1.2 0.093 13.1 1.2 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5383) FAM184 PF15665.5 ETO27567.1 - 0.12 12.1 7.3 0.33 10.7 7.3 1.8 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B ZnuA PF01297.17 ETO27567.1 - 0.17 11.3 0.1 0.3 10.5 0.1 1.4 1 0 0 1 1 1 0 Zinc-uptake complex component A periplasmic Pex24p PF06398.11 ETO27567.1 - 0.18 10.8 1.9 0.24 10.3 1.9 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin PTH2 PF01981.16 ETO27570.1 - 1.5e-42 144.5 0.0 5e-42 142.9 0.0 1.8 1 1 0 1 1 1 1 Peptidyl-tRNA hydrolase PTH2 Mito_carr PF00153.27 ETO27572.1 - 0.079 12.9 0.0 0.14 12.1 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial carrier protein Ank_2 PF12796.7 ETO27573.1 - 1.6e-21 76.7 3.8 3.2e-13 50.1 0.1 3.3 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO27573.1 - 4.3e-20 69.7 1.7 6.4e-08 32.3 0.1 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank PF00023.30 ETO27573.1 - 4.7e-19 67.9 5.4 2.6e-09 37.1 0.0 5.4 5 0 0 5 5 5 3 Ankyrin repeat Ank_4 PF13637.6 ETO27573.1 - 2.2e-17 63.1 2.6 2.4e-10 40.7 0.2 3.9 4 0 0 4 4 4 3 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO27573.1 - 1.9e-13 50.3 22.0 2.2e-06 27.8 0.1 5.4 3 2 2 5 5 5 3 Ankyrin repeats (many copies) YL1 PF05764.13 ETO27575.1 - 0.012 15.7 25.6 0.012 15.7 25.6 3.6 2 1 0 3 3 3 0 YL1 nuclear protein Caldesmon PF02029.15 ETO27575.1 - 0.015 14.1 33.7 0.0063 15.3 11.2 2.2 2 0 0 2 2 2 0 Caldesmon DUF2126 PF09899.9 ETO27575.1 - 1.6 6.7 10.1 0.33 9.0 3.5 2.3 2 0 0 2 2 2 0 Putative amidoligase enzyme (DUF2126) Nop53 PF07767.11 ETO27575.1 - 8.2 5.7 51.5 0.13 11.6 26.2 3.5 3 0 0 3 3 3 0 Nop53 (60S ribosomal biogenesis) Beta_helix_2 PF18835.1 ETO27576.1 - 0.069 12.9 0.6 0.2 11.5 0.6 1.7 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase SH3_15 PF18346.1 ETO27576.1 - 0.09 13.1 0.5 2.3 8.6 0.1 2.5 2 0 0 2 2 2 0 Mind bomb SH3 repeat domain Agenet PF05641.12 ETO27576.1 - 0.091 13.2 0.5 5.9 7.4 0.0 2.6 2 0 0 2 2 2 0 Agenet domain Ric8 PF10165.9 ETO27578.1 - 0.0014 17.7 1.2 0.0019 17.3 1.2 1.2 1 0 0 1 1 1 1 Guanine nucleotide exchange factor synembryn DUF2663 PF10864.8 ETO27579.1 - 0.081 13.3 5.3 0.098 13.1 0.0 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2663) Vma12 PF11712.8 ETO27579.1 - 0.13 12.3 1.6 0.43 10.7 1.6 1.9 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF1772 PF08592.11 ETO27579.1 - 0.25 11.6 7.0 2.3 8.6 1.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) ECF_trnsprt PF12822.7 ETO27579.1 - 5.8 7.0 11.1 14 5.7 10.4 1.9 1 1 1 2 2 2 0 ECF transporter, substrate-specific component Pkinase PF00069.25 ETO27580.1 - 2.9e-29 102.2 0.5 9.6e-28 97.3 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27580.1 - 4.3e-14 52.4 0.0 1.6e-06 27.6 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO27580.1 - 0.04 12.9 0.0 0.073 12.0 0.0 1.4 1 0 0 1 1 1 0 Haspin like kinase domain IFT57 PF10498.9 ETO27581.1 - 2.1e-41 142.1 12.8 3.3e-41 141.5 12.8 1.3 1 1 0 1 1 1 1 Intra-flagellar transport protein 57 DUF4628 PF15429.6 ETO27582.1 - 0.048 13.3 0.1 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4628) RGS PF00615.19 ETO27583.1 - 0.011 16.1 0.2 0.51 10.6 0.0 2.2 2 0 0 2 2 2 0 Regulator of G protein signaling domain FAM150 PF15129.6 ETO27583.1 - 0.035 14.2 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 FAM150 family ECH_1 PF00378.20 ETO27584.1 - 6.2e-11 42.1 0.9 1.3e-10 41.0 0.0 1.8 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO27584.1 - 1.3e-05 24.9 0.5 2.2e-05 24.1 0.0 1.5 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase Peptidase_M41 PF01434.18 ETO27585.1 - 1.8e-52 178.0 0.1 1.7e-47 161.8 0.0 2.2 2 0 0 2 2 2 2 Peptidase family M41 DUF4834 PF16118.5 ETO27587.1 - 0.0069 17.3 0.8 0.0069 17.3 0.8 2.3 3 0 0 3 3 3 1 Domain of unknown function (DUF4834) SUZ PF12752.7 ETO27587.1 - 0.012 16.4 0.2 0.024 15.4 0.2 1.5 1 0 0 1 1 1 0 SUZ domain SR-25 PF10500.9 ETO27587.1 - 0.048 13.3 6.0 0.098 12.3 6.0 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CENP-Q PF13094.6 ETO27587.1 - 0.38 10.9 0.1 0.38 10.9 0.1 2.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit SWIM PF04434.17 ETO27589.1 - 0.18 11.5 0.1 0.18 11.5 0.1 1.8 2 0 0 2 2 2 0 SWIM zinc finger Wzy_C_2 PF11846.8 ETO27592.1 - 0.64 9.9 3.7 0.97 9.3 0.3 2.3 3 0 0 3 3 3 0 Virulence factor membrane-bound polymerase, C-terminal CdiI_N PF18228.1 ETO27593.1 - 0.11 12.4 0.6 13 5.6 0.2 2.7 2 0 0 2 2 2 0 CdiI N-terminal domain NPR3 PF03666.13 ETO27594.1 - 0.035 12.9 12.8 0.055 12.3 12.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Suf PF05843.14 ETO27594.1 - 0.62 10.0 7.7 3.8 7.4 4.5 2.0 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Menin PF05053.13 ETO27594.1 - 1.2 7.5 13.1 1.7 6.9 13.1 1.2 1 0 0 1 1 1 0 Menin Mucin PF01456.17 ETO27594.1 - 2.2 8.3 10.9 3.5 7.6 10.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein TB2_DP1_HVA22 PF03134.19 ETO27595.1 - 3.1e-07 30.2 0.8 9.2e-07 28.7 0.1 2.0 2 0 0 2 2 2 1 TB2/DP1, HVA22 family Angiomotin_C PF12240.8 ETO27595.1 - 0.087 12.4 0.6 0.14 11.7 0.1 1.5 2 0 0 2 2 2 0 Angiomotin C terminal Glycos_transf_1 PF00534.20 ETO27596.1 - 2.4e-31 108.6 0.0 2.4e-15 56.5 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO27596.1 - 1.6e-29 103.0 0.0 1.9e-13 51.0 0.0 2.4 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ETO27596.1 - 4.4e-06 27.0 0.0 0.0026 18.1 0.0 2.5 2 0 0 2 2 2 2 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ETO27596.1 - 5.6e-06 26.5 0.7 0.048 13.6 0.0 2.7 2 0 0 2 2 2 2 Glycosyltransferase Family 4 SMC_hinge PF06470.13 ETO27597.1 - 5.1e-25 88.0 0.0 2.5e-24 85.8 0.0 2.3 2 0 0 2 2 2 1 SMC proteins Flexible Hinge Domain SMC_N PF02463.19 ETO27597.1 - 2.1e-21 76.4 28.0 3.2e-21 75.8 28.0 1.4 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_21 PF13304.6 ETO27597.1 - 1.6e-09 38.1 0.1 8e-09 35.7 0.0 2.4 2 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system DUF4094 PF13334.6 ETO27597.1 - 0.0079 16.6 4.3 0.0079 16.6 4.3 5.9 4 2 3 7 7 7 1 Domain of unknown function (DUF4094) DEAD PF00270.29 ETO27597.1 - 0.08 12.7 3.6 3.3 7.5 0.0 2.8 2 0 0 2 2 2 0 DEAD/DEAH box helicase DUF1664 PF07889.12 ETO27597.1 - 0.23 11.5 45.8 0.26 11.3 6.9 5.7 3 1 1 5 5 5 0 Protein of unknown function (DUF1664) Peptidase_C14 PF00656.22 ETO27598.1 - 7e-16 58.9 1.3 7e-16 58.9 1.3 1.7 2 0 0 2 2 2 1 Caspase domain Caleosin PF05042.13 ETO27598.1 - 0.061 13.3 0.4 0.47 10.4 0.1 2.4 2 0 0 2 2 2 0 Caleosin related protein CDC45 PF02724.14 ETO27598.1 - 0.29 9.4 12.3 0.43 8.8 12.3 1.4 1 0 0 1 1 1 0 CDC45-like protein JCAD PF15351.6 ETO27598.1 - 1.6 6.4 8.7 1.8 6.2 8.7 1.1 1 0 0 1 1 1 0 Junctional protein associated with coronary artery disease DUF2457 PF10446.9 ETO27598.1 - 2.6 7.1 17.5 3.8 6.5 17.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PaREP1 PF05942.11 ETO27600.1 - 0.021 14.7 2.6 0.34 10.9 0.2 2.7 2 0 0 2 2 2 0 Archaeal PaREP1/PaREP8 family Ferritin PF00210.24 ETO27600.1 - 1.2 9.1 4.6 3.5 7.5 0.2 2.4 2 0 0 2 2 2 0 Ferritin-like domain Hist_deacetyl PF00850.19 ETO27601.1 - 2.4e-28 99.5 0.1 3.4e-28 99.0 0.1 1.2 1 0 0 1 1 1 1 Histone deacetylase domain Metallophos PF00149.28 ETO27603.1 - 2e-06 28.5 0.0 2e-06 28.5 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO27603.1 - 3.6e-05 24.0 0.0 4e-05 23.9 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain PHD PF00628.29 ETO27604.1 - 4e-07 29.8 11.5 7.5e-07 28.9 11.5 1.4 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETO27604.1 - 8.6e-05 22.0 2.6 0.00017 21.1 2.6 1.5 1 0 0 1 1 1 1 PHD-finger ABC2_membrane_3 PF12698.7 ETO27604.1 - 0.0024 17.0 0.2 0.0034 16.6 0.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein Med3 PF11593.8 ETO27605.1 - 2.3e-05 23.8 9.6 2.3e-05 23.8 9.6 3.2 3 0 0 3 3 3 1 Mediator complex subunit 3 fungal Paf1 PF03985.13 ETO27605.1 - 0.0062 15.6 4.8 0.0062 15.6 4.8 4.0 3 2 1 4 4 4 1 Paf1 Acyl-thio_N PF12590.8 ETO27605.1 - 0.57 10.7 12.8 3.8 8.1 2.7 2.8 2 0 0 2 2 2 0 Acyl-ATP thioesterase Pex14_N PF04695.13 ETO27605.1 - 2.1 9.0 29.3 2.5 8.7 12.7 3.4 3 0 0 3 3 3 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Vpu PF00558.19 ETO27605.1 - 2.1 8.2 7.5 0.097 12.5 0.9 2.2 2 0 0 2 2 2 0 Vpu protein TPR_12 PF13424.6 ETO27606.1 - 8.2e-22 77.3 0.8 2.7e-10 40.4 0.2 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27606.1 - 7.3e-20 70.2 2.6 1.3e-07 31.3 0.6 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27606.1 - 2e-18 65.3 14.1 2.1e-09 36.8 1.4 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27606.1 - 1.2e-17 62.6 8.2 3.8e-08 32.8 0.4 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27606.1 - 1.1e-14 53.4 12.1 4.7e-06 26.4 0.5 4.6 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27606.1 - 2.3e-14 52.3 14.8 4.6e-07 29.4 1.1 4.6 3 1 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27606.1 - 1.2e-07 31.3 15.3 0.025 14.2 2.7 5.9 4 1 1 5 5 5 2 TPR repeat TPR_16 PF13432.6 ETO27606.1 - 0.00036 21.1 0.1 0.037 14.7 0.1 3.0 3 1 1 4 4 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO27606.1 - 0.00037 20.5 5.8 0.11 12.6 0.1 3.9 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETO27606.1 - 0.00051 19.5 0.9 0.0021 17.5 0.5 1.8 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 ETO27606.1 - 0.0006 20.4 0.3 1.4 9.9 0.0 3.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO27606.1 - 0.00099 19.1 4.4 0.011 15.7 1.7 2.8 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO27606.1 - 0.0029 18.2 3.6 0.99 10.2 0.1 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO27606.1 - 0.0081 15.9 2.8 0.93 9.2 0.2 2.3 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_MalT PF17874.1 ETO27606.1 - 0.026 13.9 0.1 0.14 11.5 0.0 1.9 1 1 1 2 2 2 0 MalT-like TPR region DUF627 PF04781.12 ETO27606.1 - 0.04 13.9 0.5 0.22 11.5 0.1 2.3 2 1 1 3 3 3 0 Protein of unknown function (DUF627) DUF1402 PF07182.11 ETO27606.1 - 0.067 12.3 1.0 0.11 11.5 0.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1402) TPR_17 PF13431.6 ETO27606.1 - 0.07 13.5 10.0 0.36 11.3 0.5 4.1 2 1 1 3 3 3 0 Tetratricopeptide repeat BTAD PF03704.17 ETO27606.1 - 0.11 13.0 0.0 5.6 7.4 0.0 2.2 2 0 0 2 2 2 0 Bacterial transcriptional activator domain DUF5113 PF17140.4 ETO27606.1 - 0.11 12.3 8.4 2.6 7.8 0.3 3.3 2 1 1 4 4 4 0 Domain of unknown function (DUF5113) UFD1 PF03152.14 ETO27608.1 - 6.1e-36 123.5 0.0 8.1e-36 123.1 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin fusion degradation protein UFD1 CDC48_2 PF02933.17 ETO27608.1 - 0.00056 19.6 0.1 0.0017 18.1 0.0 1.8 2 0 0 2 2 2 1 Cell division protein 48 (CDC48), domain 2 DcuA_DcuB PF03605.14 ETO27608.1 - 0.099 11.5 0.0 0.14 11.0 0.0 1.1 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter DUF1043 PF06295.12 ETO27609.1 - 0.0019 18.2 2.1 0.0024 17.9 2.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1043) Pox_A32 PF04665.12 ETO27609.1 - 0.0026 17.3 1.1 0.0029 17.1 1.1 1.0 1 0 0 1 1 1 1 Poxvirus A32 protein DUF2974 PF11187.8 ETO27609.1 - 0.055 13.0 0.0 0.058 13.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2974) CAP_N PF01213.19 ETO27610.1 - 2.2e-16 60.2 0.2 2.4e-16 60.1 0.2 1.0 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Ribosomal_60s PF00428.19 ETO27610.1 - 0.00027 21.5 1.5 0.00036 21.1 1.5 1.1 1 0 0 1 1 1 1 60s Acidic ribosomal protein CAP_N PF01213.19 ETO27611.1 - 0.00037 20.1 0.0 0.003 17.1 0.0 2.2 2 1 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal PP2C PF00481.21 ETO27612.1 - 5.2e-24 85.3 0.0 2.3e-23 83.1 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C Sad1_UNC PF07738.13 ETO27613.1 - 0.0041 17.1 1.0 0.016 15.3 0.0 2.4 3 0 0 3 3 3 1 Sad1 / UNC-like C-terminal DUF913 PF06025.12 ETO27613.1 - 0.045 12.7 12.3 0.22 10.4 1.1 3.1 3 0 0 3 3 3 0 Domain of Unknown Function (DUF913) DraK_HK_N PF18092.1 ETO27613.1 - 0.061 13.8 0.1 0.24 11.8 0.1 2.0 1 0 0 1 1 1 0 DraK Histidine Kinase N-terminal domain DUF1664 PF07889.12 ETO27613.1 - 3.4 7.7 9.5 0.36 10.9 3.6 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CAP_GLY PF01302.25 ETO27614.1 - 3.2e-110 360.2 33.9 6.3e-22 77.4 0.5 7.2 7 0 0 7 7 7 7 CAP-Gly domain DUF3189 PF11385.8 ETO27614.1 - 0.032 14.1 0.4 0.26 11.1 0.1 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3189) YajC PF02699.15 ETO27614.1 - 3.3 7.6 16.9 2.7 7.9 0.1 5.7 7 0 0 7 7 7 0 Preprotein translocase subunit SH3_13 PF18335.1 ETO27614.1 - 4.7 7.1 6.9 17 5.3 0.0 4.6 6 0 0 6 6 6 0 ATP-dependent RecD-like DNA helicase SH3 domain EF-hand_6 PF13405.6 ETO27615.1 - 4.6e-08 32.4 3.6 0.12 12.4 0.1 4.4 4 0 0 4 4 4 3 EF-hand domain EF-hand_7 PF13499.6 ETO27615.1 - 0.0058 17.1 9.5 0.93 10.0 0.3 4.1 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO27615.1 - 0.076 12.6 15.2 0.66 9.7 0.2 5.2 5 0 0 5 5 5 0 EF hand EF-hand_5 PF13202.6 ETO27615.1 - 2.8 7.6 11.8 1 9.0 0.5 3.8 4 0 0 4 4 4 0 EF hand RPEL PF02755.15 ETO27616.1 - 0.005 16.5 6.4 0.23 11.2 0.2 4.0 3 0 0 3 3 3 2 RPEL repeat Band_7_1 PF13421.6 ETO27616.1 - 1.8 8.2 8.8 0.13 12.0 0.4 2.5 2 1 0 2 2 2 0 SPFH domain-Band 7 family ATP-synt_8 PF00895.20 ETO27617.1 - 0.31 11.5 8.1 0.35 11.4 2.8 2.3 2 0 0 2 2 2 0 ATP synthase protein 8 DUF2569 PF10754.9 ETO27617.1 - 0.4 11.1 4.9 0.75 10.2 4.9 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2569) GRP PF07172.11 ETO27617.1 - 0.72 10.6 2.0 0.9 10.3 0.1 1.9 2 0 0 2 2 2 0 Glycine rich protein family DUF5113 PF17140.4 ETO27618.1 - 0.00033 20.5 2.3 0.22 11.3 0.2 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF5113) Maf1 PF09174.10 ETO27618.1 - 0.013 15.7 0.7 0.013 15.7 0.7 1.8 2 0 0 2 2 2 0 Maf1 regulator Mg296 PF09644.10 ETO27618.1 - 0.016 15.3 0.2 0.016 15.3 0.2 2.1 2 1 0 2 2 2 0 Mg296 protein Rogdi_lz PF10259.9 ETO27618.1 - 0.041 13.3 0.2 0.092 12.2 0.1 1.6 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein RGS PF00615.19 ETO27620.1 - 5.2e-06 26.7 0.2 0.0062 16.8 0.0 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain PSCyt3 PF07627.11 ETO27620.1 - 0.18 12.1 1.3 0.94 9.8 0.0 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1588) Ribosomal_60s PF00428.19 ETO27621.1 - 9.4e-10 38.9 22.6 1e-08 35.6 22.6 2.0 1 1 0 1 1 1 1 60s Acidic ribosomal protein Jag_N PF14804.6 ETO27621.1 - 0.00045 20.5 0.1 0.00085 19.6 0.1 1.5 1 0 0 1 1 1 1 Jag N-terminus DUF1525 PF07511.11 ETO27621.1 - 0.036 14.2 0.0 0.066 13.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1525) DUF3824 PF12868.7 ETO27621.1 - 0.41 11.3 2.9 0.63 10.7 2.9 1.2 1 0 0 1 1 1 0 Domain of unknwon function (DUF3824) LAP1C PF05609.12 ETO27623.1 - 0.13 11.4 21.9 0.16 11.0 21.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) 2OG-FeII_Oxy_2 PF13532.6 ETO27624.1 - 5.9e-14 52.7 0.0 2.2e-13 50.9 0.0 2.0 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily SieB PF14163.6 ETO27625.1 - 0.096 12.2 0.9 0.1 12.1 0.1 1.5 2 0 0 2 2 2 0 Super-infection exclusion protein B ABC_tran PF00005.27 ETO27626.1 - 2.3e-29 102.7 0.1 6.2e-29 101.3 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ETO27626.1 - 1.2e-09 38.4 0.6 5.2e-07 29.8 0.0 2.9 3 0 0 3 3 3 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO27626.1 - 0.0063 16.0 0.0 0.93 8.9 0.0 2.3 2 0 0 2 2 2 2 RecF/RecN/SMC N terminal domain AAA_23 PF13476.6 ETO27626.1 - 0.014 15.9 1.4 0.025 15.1 0.1 1.9 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO27626.1 - 0.017 14.8 0.1 0.041 13.6 0.1 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain SbcCD_C PF13558.6 ETO27626.1 - 0.08 13.2 0.0 0.54 10.5 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit RCC1_2 PF13540.6 ETO27626.1 - 0.12 12.2 0.0 0.44 10.4 0.0 2.0 1 0 0 1 1 1 0 Regulator of chromosome condensation (RCC1) repeat RsgA_GTPase PF03193.16 ETO27626.1 - 0.12 12.2 0.0 0.24 11.3 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase ABC2_membrane_3 PF12698.7 ETO27627.1 - 6.7e-28 97.8 15.4 9.7e-28 97.3 15.4 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein Asp5 PF17000.5 ETO27627.1 - 0.16 12.1 0.1 0.16 12.1 0.1 4.0 3 1 1 4 4 4 0 Accessory secretory protein Sec, Asp5 DUF3087 PF11286.8 ETO27627.1 - 0.22 10.9 2.1 0.45 10.0 2.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) Diphthamide_syn PF01866.17 ETO27629.1 - 3.2e-105 351.9 0.0 5.7e-105 351.1 0.0 1.4 1 0 0 1 1 1 1 Putative diphthamide synthesis protein Adaptin_binding PF10199.9 ETO27630.1 - 3.6e-05 24.3 4.1 0.00019 22.0 4.1 2.3 1 1 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 DUF966 PF06136.13 ETO27630.1 - 0.045 13.5 12.5 0.077 12.7 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) TRAP_alpha PF03896.16 ETO27630.1 - 0.66 9.1 8.7 1.5 7.9 8.7 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Borrelia_P83 PF05262.11 ETO27630.1 - 2.7 6.4 19.4 4.6 5.6 19.4 1.4 1 0 0 1 1 1 0 Borrelia P83/100 protein Presenilin PF01080.17 ETO27630.1 - 2.9 6.6 15.6 4.8 5.8 15.6 1.3 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO27630.1 - 5.7 5.9 11.2 12 4.8 11.2 1.5 1 0 0 1 1 1 0 Solute carrier family 12 FHIPEP PF00771.20 ETO27630.1 - 5.7 5.3 5.9 11 4.4 5.9 1.4 1 0 0 1 1 1 0 FHIPEP family PPP4R2 PF09184.11 ETO27630.1 - 8.6 5.9 25.8 28 4.2 25.8 1.8 1 0 0 1 1 1 0 PPP4R2 DUF908 PF06012.12 ETO27631.1 - 0.33 10.3 5.0 0.41 10.0 5.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Pkinase PF00069.25 ETO27632.1 - 4.4e-25 88.5 1.4 2.4e-20 73.0 0.1 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27632.1 - 2.3e-11 43.5 0.0 4e-11 42.7 0.0 1.3 1 1 0 1 1 1 1 Protein tyrosine kinase Ribosomal_60s PF00428.19 ETO27634.1 - 0.038 14.6 4.8 0.066 13.8 4.8 1.3 1 0 0 1 1 1 0 60s Acidic ribosomal protein DUF2956 PF11169.8 ETO27634.1 - 0.04 14.1 4.1 0.1 12.8 4.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Mre11_DNA_bind PF04152.14 ETO27634.1 - 0.045 14.1 1.8 9.4 6.5 2.4 2.5 2 0 0 2 2 2 0 Mre11 DNA-binding presumed domain GOLD_2 PF13897.6 ETO27634.1 - 0.085 13.4 0.4 0.16 12.5 0.4 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF3682 PF12446.8 ETO27634.1 - 5.5 7.5 8.3 13 6.3 8.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) BRE1 PF08647.11 ETO27636.1 - 0.009 16.1 10.3 0.009 16.1 10.3 10.8 6 3 4 11 11 11 3 BRE1 E3 ubiquitin ligase ArsP_2 PF11449.8 ETO27636.1 - 0.24 10.6 0.6 0.53 9.4 0.6 1.5 1 0 0 1 1 1 0 Putative, 10TM heavy-metal exporter Filament PF00038.21 ETO27636.1 - 2.8 7.4 150.0 0.091 12.3 39.7 7.8 5 2 2 7 7 7 0 Intermediate filament protein TMF_DNA_bd PF12329.8 ETO27639.1 - 0.005 16.8 19.9 0.005 16.8 19.9 2.7 3 0 0 3 3 3 1 TATA element modulatory factor 1 DNA binding WW PF00397.26 ETO27639.1 - 0.065 13.3 0.4 0.11 12.6 0.4 1.4 1 0 0 1 1 1 0 WW domain FAM184 PF15665.5 ETO27639.1 - 0.16 11.7 24.5 0.57 9.9 24.3 1.9 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B ADIP PF11559.8 ETO27639.1 - 0.46 10.6 22.5 0.58 10.2 16.0 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding ApoO PF09769.9 ETO27639.1 - 0.46 10.4 5.2 0.43 10.5 2.4 2.2 3 0 0 3 3 3 0 Apolipoprotein O DUF1319 PF07028.11 ETO27639.1 - 0.59 10.4 11.4 0.54 10.5 7.5 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) CLN3 PF02487.17 ETO27639.1 - 0.67 8.9 4.5 1 8.3 4.5 1.3 1 0 0 1 1 1 0 CLN3 protein Helitron_like_N PF14214.6 ETO27639.1 - 1.5 9.0 7.1 1.2 9.3 5.0 1.9 2 0 0 2 2 2 0 Helitron helicase-like domain at N-terminus Baculo_PEP_C PF04513.12 ETO27639.1 - 1.6 8.8 7.7 0.38 10.8 3.6 1.9 2 1 1 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Sipho_Gp157 PF05565.11 ETO27639.1 - 1.8 8.5 23.3 0.099 12.6 14.8 2.3 1 1 1 2 2 2 0 Siphovirus Gp157 DUF3573 PF12097.8 ETO27639.1 - 2.6 6.8 4.2 3.6 6.3 4.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) FlaC_arch PF05377.11 ETO27639.1 - 2.8 8.4 8.6 2.4 8.6 5.2 2.7 2 1 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF2203 PF09969.9 ETO27639.1 - 3.2 8.5 10.1 1.4 9.6 5.5 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) COX16 PF14138.6 ETO27639.1 - 5.2 7.6 7.5 1 9.9 3.2 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein COX16 LMBR1 PF04791.16 ETO27639.1 - 5.5 5.8 9.4 6.1 5.6 9.4 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein GrpE PF01025.19 ETO27639.1 - 7.4 6.2 20.6 1.4 8.5 12.4 2.4 2 1 0 2 2 2 0 GrpE RGS PF00615.19 ETO27640.1 - 2e-08 34.5 1.7 4.9e-08 33.3 1.7 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain STPPase_N PF16891.5 ETO27641.1 - 8.5e-16 58.1 0.3 1.5e-15 57.4 0.3 1.4 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain GET2 PF08690.10 ETO27641.1 - 4.7 6.8 7.7 6 6.4 7.7 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 Mucin PF01456.17 ETO27641.1 - 9.2 6.2 11.9 13 5.8 11.9 1.3 1 1 0 1 1 1 0 Mucin-like glycoprotein ZZ PF00569.17 ETO27642.1 - 0.0059 16.4 0.8 0.015 15.1 0.8 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type REF PF05755.12 ETO27642.1 - 0.7 9.7 3.6 12 5.7 0.0 3.8 3 0 0 3 3 3 0 Rubber elongation factor protein (REF) FoP_duplication PF13865.6 ETO27642.1 - 0.98 10.0 7.3 0.22 12.1 2.5 2.3 2 0 0 2 2 2 0 C-terminal duplication domain of Friend of PRMT1 DUF3783 PF12646.7 ETO27642.1 - 1.9 8.5 5.0 6.1 6.9 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function (DUF3783) VPS11_C PF12451.8 ETO27643.1 - 0.027 14.7 0.3 0.2 11.9 0.0 2.4 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal WD40 PF00400.32 ETO27644.1 - 4.9e-05 24.0 0.3 0.6 11.1 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat HCV_NS5a PF01506.19 ETO27644.1 - 1.9 8.4 6.9 0.69 9.8 1.1 2.4 2 0 0 2 2 2 0 Hepatitis C virus non-structural 5a protein membrane anchor Kinesin PF00225.23 ETO27645.1 - 1.5e-20 73.4 0.2 1.5e-20 73.4 0.2 3.1 4 1 0 4 4 4 1 Kinesin motor domain DivIC PF04977.15 ETO27645.1 - 0.00058 19.6 1.9 0.00058 19.6 1.9 8.3 5 2 2 7 7 7 2 Septum formation initiator Cytochrom_B562 PF07361.11 ETO27645.1 - 0.014 16.0 3.3 0.014 16.0 3.3 5.3 4 1 1 5 5 5 0 Cytochrome b562 TA_inhibitor PF17574.2 ETO27645.1 - 0.025 14.6 0.3 0.086 12.9 0.3 2.0 1 0 0 1 1 1 0 Inhibitor of toxin/antitoxin system (Gp4.5) GDPD_2 PF13653.6 ETO27645.1 - 0.19 12.2 0.0 0.63 10.6 0.0 1.8 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family kleA_kleC PF17383.2 ETO27645.1 - 2.5 8.5 20.4 0.91 9.9 1.5 4.5 4 0 0 4 4 4 0 Uncharacterized KorC regulated protein A TMEM190 PF15431.6 ETO27647.1 - 0.037 14.2 0.9 0.13 12.4 0.6 2.0 2 0 0 2 2 2 0 Transmembrane protein 190 DUF4342 PF14242.6 ETO27647.1 - 0.18 11.8 4.3 0.52 10.3 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4342) DDA1 PF10172.9 ETO27648.1 - 0.033 14.5 0.3 0.19 12.0 0.1 2.1 2 0 0 2 2 2 0 Det1 complexing ubiquitin ligase DBB PF14545.6 ETO27649.1 - 0.04 13.8 0.3 0.061 13.2 0.3 1.3 1 0 0 1 1 1 0 Dof, BCAP, and BANK (DBB) motif, DUF3848 PF12959.7 ETO27649.1 - 0.16 12.1 4.1 0.16 12.0 3.0 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3848) Usher PF00577.20 ETO27649.1 - 1.4 7.7 3.3 1.7 7.4 3.3 1.1 1 0 0 1 1 1 0 Outer membrane usher protein PPR PF01535.20 ETO27650.1 - 0.0039 17.3 0.1 7.9 7.0 0.0 3.2 2 0 0 2 2 2 2 PPR repeat PPR_3 PF13812.6 ETO27650.1 - 0.0056 16.7 0.0 0.18 11.9 0.0 2.5 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO27650.1 - 0.0061 16.7 0.3 9.7 6.5 0.0 4.0 4 0 0 4 4 4 1 PPR repeat family DUF724 PF05266.14 ETO27650.1 - 0.042 13.7 0.2 0.062 13.1 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PI3K_P85_iSH2 PF16454.5 ETO27650.1 - 0.042 13.4 0.1 0.057 13.0 0.1 1.3 1 0 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DUF3043 PF11241.8 ETO27651.1 - 0.041 13.9 2.3 0.094 12.7 2.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) GPCR_chapero_1 PF11904.8 ETO27651.1 - 0.093 12.2 6.7 0.18 11.2 6.7 1.5 1 0 0 1 1 1 0 GPCR-chaperone dsRBD2 PF17842.1 ETO27651.1 - 1.6 9.0 11.8 0.13 12.4 6.0 2.2 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 AP3D1 PF06375.11 ETO27651.1 - 3.6 7.8 23.9 0.031 14.5 14.5 2.3 2 0 0 2 2 2 0 AP-3 complex subunit delta-1 FYDLN_acid PF09538.10 ETO27651.1 - 4.6 8.0 20.1 0.36 11.5 9.5 3.0 3 0 0 3 3 3 0 Protein of unknown function (FYDLN_acid) PBP_sp32 PF07222.12 ETO27651.1 - 7.2 6.0 20.8 0.19 11.1 14.3 1.6 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Connexin PF00029.19 ETO27651.1 - 8.1 6.1 13.4 0.08 12.7 4.9 2.0 3 0 0 3 3 3 0 Connexin UPF0061 PF02696.14 ETO27652.1 - 9.4e-43 146.6 16.1 5.3e-24 84.8 0.2 2.9 2 1 0 2 2 2 2 Uncharacterized ACR, YdiU/UPF0061 family DUF4600 PF15372.6 ETO27652.1 - 0.0065 16.9 0.8 0.014 15.8 0.8 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4600) DUF3585 PF12130.8 ETO27652.1 - 0.062 13.4 3.1 3.9 7.6 1.3 2.7 2 0 0 2 2 2 0 Bivalent Mical/EHBP Rab binding domain Herpes_US12 PF05363.12 ETO27652.1 - 0.15 12.8 0.1 0.31 11.8 0.1 1.5 1 0 0 1 1 1 0 Herpesvirus US12 family BUD22 PF09073.10 ETO27653.1 - 0.00051 19.5 25.7 0.00051 19.5 25.7 3.7 3 1 1 4 4 4 2 BUD22 RIFIN PF02009.16 ETO27653.1 - 0.0072 16.3 8.1 0.0072 16.3 8.1 5.3 2 2 3 5 5 5 1 Rifin DUF3139 PF11337.8 ETO27653.1 - 0.024 15.3 1.3 0.18 12.4 1.3 2.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) ODV-E18 PF10717.9 ETO27653.1 - 0.064 13.1 3.8 0.29 11.0 3.8 2.2 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ASFV_J13L PF05568.11 ETO27653.1 - 0.078 12.7 1.8 0.31 10.8 1.8 2.1 1 0 0 1 1 1 0 African swine fever virus J13L protein Wzy_C PF04932.15 ETO27653.1 - 0.097 12.3 0.0 0.24 11.0 0.0 1.7 1 0 0 1 1 1 0 O-Antigen ligase ATP-synt_8 PF00895.20 ETO27653.1 - 3 8.4 5.3 1.4 9.4 0.2 3.3 2 0 0 2 2 2 0 ATP synthase protein 8 ADH_zinc_N PF00107.26 ETO27655.1 - 1.7e-22 79.8 0.1 3.2e-22 78.9 0.1 1.4 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO27655.1 - 3e-06 28.3 0.0 6.1e-06 27.3 0.0 1.5 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO27655.1 - 0.014 15.3 2.1 0.028 14.3 2.1 1.5 1 0 0 1 1 1 0 Alcohol dehydrogenase GroES-like domain 2-Hacid_dh_C PF02826.19 ETO27655.1 - 0.14 11.6 0.0 0.23 10.8 0.0 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ETO27655.1 - 0.24 10.6 0.7 0.43 9.9 0.1 1.7 2 0 0 2 2 2 0 Alanine dehydrogenase/PNT, C-terminal domain SPO22 PF08631.10 ETO27656.1 - 0.00012 21.6 0.3 0.00027 20.5 0.3 1.6 1 0 0 1 1 1 1 Meiosis protein SPO22/ZIP4 like TPR_12 PF13424.6 ETO27656.1 - 0.0067 16.7 0.1 10 6.5 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27656.1 - 0.0071 16.4 0.1 0.95 9.7 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TolA_bind_tri PF16331.5 ETO27656.1 - 0.19 11.8 0.8 6.6 6.9 0.0 2.8 2 1 0 2 2 2 0 TolA binding protein trimerisation DUF4094 PF13334.6 ETO27656.1 - 0.6 10.6 3.3 8.7 6.8 0.0 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4094) Spc42p PF11544.8 ETO27656.1 - 2.7 8.1 6.5 1.4 9.0 1.2 3.1 3 0 0 3 3 3 0 Spindle pole body component Spc42p FlaC_arch PF05377.11 ETO27656.1 - 4.9 7.6 5.7 12 6.4 0.2 2.9 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) Pox_A_type_inc PF04508.12 ETO27656.1 - 8.1 6.5 7.1 0.71 9.8 0.2 3.0 4 0 0 4 4 4 0 Viral A-type inclusion protein repeat HTH_Tnp_1 PF01527.20 ETO27657.1 - 0.016 15.5 0.0 0.016 15.5 0.0 2.7 3 0 0 3 3 3 0 Transposase MerR_1 PF13411.6 ETO27657.1 - 0.039 14.0 0.0 0.091 12.9 0.0 1.6 1 0 0 1 1 1 0 MerR HTH family regulatory protein AAA_assoc_C PF09821.9 ETO27657.1 - 0.046 14.3 1.4 0.1 13.1 0.8 1.8 2 0 0 2 2 2 0 C-terminal AAA-associated domain DUF3381 PF11861.8 ETO27657.1 - 0.4 10.5 10.7 2.2 8.1 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3381) Occludin_ELL PF07303.13 ETO27657.1 - 2.5 8.9 11.9 1.2 9.8 2.0 3.2 2 1 1 3 3 3 0 Occludin homology domain PCRF PF03462.18 ETO27657.1 - 4.1 7.2 7.4 0.46 10.3 0.6 2.5 2 1 0 3 3 3 0 PCRF domain Cdc6_C PF09079.11 ETO27659.1 - 0.1 12.6 0.0 0.21 11.6 0.0 1.6 1 1 0 1 1 1 0 CDC6, C terminal winged helix domain Calci_bind_CcbP PF11535.8 ETO27660.1 - 0.033 14.7 4.2 0.05 14.1 0.0 2.8 3 0 0 3 3 3 0 Calcium binding zf-C2H2_4 PF13894.6 ETO27662.1 - 5.8e-08 32.9 21.2 0.0092 16.7 0.8 3.5 3 0 0 3 3 3 3 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO27662.1 - 1.5e-07 31.5 25.6 6.7e-05 23.1 2.2 3.5 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO27662.1 - 3.6e-06 27.1 19.3 1.2e-05 25.6 3.1 4.4 4 1 0 4 4 3 1 Zinc-finger double domain PhnJ PF06007.11 ETO27662.1 - 0.011 14.7 1.0 0.08 11.9 0.3 2.0 1 1 1 2 2 2 0 Phosphonate metabolism protein PhnJ zf-C2H2_jaz PF12171.8 ETO27662.1 - 0.053 13.8 17.3 0.66 10.3 1.0 3.5 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding Apc13p PF05839.11 ETO27662.1 - 0.087 13.0 0.6 0.2 11.8 0.6 1.6 1 0 0 1 1 1 0 Apc13p protein zf-Di19 PF05605.12 ETO27662.1 - 0.24 11.7 10.1 0.64 10.4 2.3 2.4 1 1 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF2256 PF10013.9 ETO27662.1 - 0.36 11.0 4.8 12 6.1 0.1 3.4 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2256) zf-MYST PF17772.1 ETO27662.1 - 1.1 9.0 9.3 2.3 7.9 1.0 2.7 2 1 0 2 2 2 0 MYST family zinc finger domain zf-met PF12874.7 ETO27662.1 - 1.1 9.7 16.0 0.81 10.2 0.1 3.5 3 0 0 3 3 3 0 Zinc-finger of C2H2 type FYVE PF01363.21 ETO27662.1 - 2.3 8.4 9.3 0.32 11.2 2.3 2.5 1 1 1 2 2 2 0 FYVE zinc finger zf-C2H2_2 PF12756.7 ETO27662.1 - 3.2 8.1 12.0 2.5 8.5 0.9 3.4 1 1 2 3 3 3 0 C2H2 type zinc-finger (2 copies) CENP-B_dimeris PF09026.10 ETO27663.1 - 3.4 8.1 13.4 0.31 11.5 2.5 2.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CAP-ZIP_m PF15255.6 ETO27665.1 - 0.24 11.7 1.8 0.38 11.0 1.8 1.3 1 0 0 1 1 1 0 WASH complex subunit CAP-Z interacting, central region DUF3388 PF11868.8 ETO27666.1 - 0.074 12.4 0.0 0.13 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3388) Eapp_C PF10238.9 ETO27668.1 - 9.8e-08 32.2 11.4 9.8e-08 32.2 11.4 2.8 2 1 1 3 3 3 1 E2F-associated phosphoprotein Yippee-Mis18 PF03226.14 ETO27668.1 - 0.0054 16.9 9.0 0.43 10.8 9.0 2.4 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly DGF-1_C PF11040.8 ETO27668.1 - 0.07 13.1 1.6 0.18 11.8 1.4 2.0 1 1 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi C-terminus NLRC4_HD2 PF17776.1 ETO27669.1 - 0.64 10.6 3.8 0.56 10.8 0.2 2.3 1 1 1 2 2 2 0 NLRC4 helical domain HD2 GNAT_acetyltr_2 PF13718.6 ETO27670.1 - 2.4e-58 197.2 0.3 2.4e-58 197.2 0.3 1.9 2 0 0 2 2 2 1 GNAT acetyltransferase 2 Helicase_RecD PF05127.14 ETO27670.1 - 1.8e-55 187.5 0.0 3.3e-54 183.4 0.0 2.7 2 1 0 2 2 2 1 Helicase DUF1726 PF08351.11 ETO27670.1 - 5.4e-22 77.5 0.0 2e-21 75.7 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF1726) Acetyltransf_1 PF00583.25 ETO27670.1 - 0.00013 22.2 0.0 0.00047 20.4 0.0 1.9 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family AAA_22 PF13401.6 ETO27670.1 - 0.0018 18.6 0.1 0.64 10.3 0.0 3.5 2 1 0 2 2 2 1 AAA domain Acetyltransf_7 PF13508.7 ETO27670.1 - 0.0018 18.6 0.0 0.009 16.4 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ETO27670.1 - 0.039 14.6 0.0 0.099 13.3 0.0 1.6 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO27670.1 - 0.096 12.6 0.2 2 8.4 0.0 2.7 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain RNA_pol_Rpb6 PF01192.22 ETO27671.1 - 4.1e-16 58.6 0.3 6.9e-16 57.9 0.3 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb6 RHD_dimer PF16179.5 ETO27671.1 - 0.054 13.5 0.2 0.12 12.4 0.2 1.6 1 0 0 1 1 1 0 Rel homology dimerisation domain NICE-3 PF07406.11 ETO27672.1 - 0.00011 22.3 0.1 0.00011 22.2 0.1 1.1 1 0 0 1 1 1 1 NICE-3 protein DUF4129 PF13559.6 ETO27672.1 - 0.13 12.5 0.0 0.19 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4129) Pet191_N PF10203.9 ETO27674.1 - 0.21 11.9 4.6 0.31 11.4 2.8 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase assembly protein PET191 NIF PF03031.18 ETO27675.1 - 1.3e-21 77.0 2.3 3.7e-21 75.5 2.3 1.8 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase BRCT PF00533.26 ETO27675.1 - 2.4e-05 24.6 0.1 7.6e-05 23.0 0.1 2.0 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain PTCB-BRCT PF12738.7 ETO27675.1 - 3.8e-05 23.6 0.1 0.0001 22.2 0.1 1.7 1 0 0 1 1 1 1 twin BRCT domain LIG3_BRCT PF16759.5 ETO27675.1 - 0.075 13.3 0.0 0.27 11.5 0.0 2.0 1 0 0 1 1 1 0 DNA ligase 3 BRCT domain NOA36 PF06524.12 ETO27675.1 - 0.32 10.3 11.9 0.84 8.9 11.9 1.7 1 0 0 1 1 1 0 NOA36 protein DUF2370 PF10176.9 ETO27675.1 - 8.8 5.9 9.9 0.54 9.9 0.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2370) tRNA_bind_2 PF13725.6 ETO27676.1 - 5.7e-35 121.1 7.1 1.2e-34 120.1 7.1 1.6 1 0 0 1 1 1 1 Possible tRNA binding domain Chromo_shadow PF01393.19 ETO27676.1 - 0.0036 17.4 0.2 0.0082 16.2 0.2 1.5 1 0 0 1 1 1 1 Chromo shadow domain HTH_10 PF04967.12 ETO27676.1 - 0.096 12.5 0.1 0.2 11.5 0.1 1.6 1 0 0 1 1 1 0 HTH DNA binding domain MDM31_MDM32 PF08118.11 ETO27677.1 - 0.021 13.5 0.6 0.027 13.2 0.6 1.1 1 0 0 1 1 1 0 Yeast mitochondrial distribution and morphology (MDM) proteins HSP70 PF00012.20 ETO27678.1 - 1.8e-63 214.7 5.1 1.5e-62 211.7 5.1 1.9 1 1 0 1 1 1 1 Hsp70 protein Recombinase PF07508.13 ETO27678.1 - 0.0089 16.4 0.6 2.4 8.6 0.0 2.3 2 0 0 2 2 2 2 Recombinase WD40 PF00400.32 ETO27679.1 - 5.7e-43 144.1 15.4 7.2e-08 33.0 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27679.1 - 4.4e-13 49.4 3.0 0.00095 19.4 0.0 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27679.1 - 4e-07 29.3 0.1 0.00063 18.8 0.1 4.3 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO27679.1 - 0.00035 19.3 0.2 0.27 9.8 0.0 3.4 1 1 4 5 5 5 2 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO27679.1 - 0.0011 18.0 0.2 0.0052 15.8 0.1 2.3 1 1 0 1 1 1 1 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 ETO27679.1 - 0.0037 17.1 0.0 5.5 7.1 0.0 3.7 4 0 0 4 4 4 1 PQQ enzyme repeat PQQ_2 PF13360.6 ETO27679.1 - 0.11 12.1 0.0 0.42 10.2 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain PD40 PF07676.12 ETO27679.1 - 0.25 11.3 1.3 14 5.7 0.1 2.7 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat bPH_3 PF14470.6 ETO27679.1 - 1.2 9.5 7.1 2 8.8 2.4 2.9 2 0 0 2 2 2 0 Bacterial PH domain WD40 PF00400.32 ETO27680.1 - 2.1e-52 173.9 9.1 4.5e-08 33.6 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27680.1 - 8e-19 67.7 2.6 0.068 13.5 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO27680.1 - 5.2e-10 39.1 8.4 0.002 17.5 0.1 3.4 3 1 0 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO27680.1 - 3.7e-07 29.4 0.0 2.3 7.1 0.0 4.9 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO27680.1 - 6.1e-07 28.5 0.6 0.5 9.0 0.0 4.3 2 2 2 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO27680.1 - 8e-06 24.6 0.4 0.075 11.5 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain Mid2 PF04478.12 ETO27680.1 - 6.5e-05 22.8 4.0 0.48 10.3 0.0 4.5 2 1 2 5 5 5 2 Mid2 like cell wall stress sensor Me-amine-dh_H PF06433.11 ETO27680.1 - 0.00093 18.2 0.1 0.87 8.4 0.0 3.1 2 1 1 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) Nbas_N PF15492.6 ETO27680.1 - 0.0026 17.1 0.3 1.7 7.9 0.0 3.0 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO27680.1 - 0.018 14.1 0.7 0.15 11.1 0.2 2.4 1 1 0 2 2 2 0 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO27680.1 - 0.025 14.5 1.1 36 4.5 0.0 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO27680.1 - 0.041 12.6 9.5 2.7 6.6 1.9 4.1 1 1 3 4 4 4 0 Nup133 N terminal like WD40 PF00400.32 ETO27681.1 - 5.5e-18 65.0 5.6 0.0067 17.3 0.1 5.2 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27681.1 - 2.1e-10 40.8 1.7 0.0017 18.6 0.1 3.8 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27681.1 - 8.6e-05 21.6 0.4 0.11 11.4 0.0 3.6 2 1 2 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO27681.1 - 0.014 14.0 2.3 1 8.0 0.2 2.2 1 1 1 2 2 2 0 Nucleoporin Nup120/160 NAGPA PF09992.9 ETO27681.1 - 0.05 13.8 0.0 0.076 13.2 0.0 1.3 1 0 0 1 1 1 0 Phosphodiester glycosidase RE_ScaI PF09569.10 ETO27681.1 - 0.66 9.7 7.2 2.3 7.9 4.5 2.8 2 2 0 2 2 2 0 ScaI restriction endonuclease PASTA PF03793.19 ETO27682.1 - 0.071 13.0 0.0 0.16 11.9 0.0 1.6 1 0 0 1 1 1 0 PASTA domain HCO3_cotransp PF00955.21 ETO27685.1 - 0.0027 16.6 3.5 0.0027 16.6 3.5 2.1 2 0 0 2 2 2 1 HCO3- transporter family Peroxin-13_N PF04088.13 ETO27685.1 - 0.64 10.3 9.2 0.48 10.7 0.4 3.4 3 0 0 3 3 3 0 Peroxin 13, N-terminal region RICTOR_N PF14664.6 ETO27686.1 - 0.029 13.4 7.9 0.077 12.0 0.2 2.6 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, N-term Nop53 PF07767.11 ETO27686.1 - 0.048 13.0 13.7 0.56 9.5 2.3 2.2 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) SDA1 PF05285.12 ETO27686.1 - 0.4 10.1 23.1 0.14 11.5 7.5 2.2 2 0 0 2 2 2 0 SDA1 YL1 PF05764.13 ETO27686.1 - 0.4 10.8 25.9 0.41 10.7 8.2 2.1 1 1 1 2 2 2 0 YL1 nuclear protein Spt5_N PF11942.8 ETO27686.1 - 0.46 11.5 28.5 0.59 11.2 10.4 2.5 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal POT1PC PF16686.5 ETO27687.1 - 0.0033 17.3 0.1 0.026 14.4 0.1 2.2 1 1 0 1 1 1 1 ssDNA-binding domain of telomere protection protein FokI_C PF02980.16 ETO27687.1 - 0.087 12.8 0.1 0.17 11.9 0.1 1.4 1 0 0 1 1 1 0 Restriction endonuclease FokI, catalytic domain Mannosyl_trans4 PF15971.5 ETO27687.1 - 0.11 12.4 0.0 0.22 11.4 0.0 1.4 1 0 0 1 1 1 0 DolP-mannose mannosyltransferase BSP_II PF05432.11 ETO27688.1 - 0.0017 18.1 12.3 0.0023 17.7 12.3 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) DNA_pol_phi PF04931.13 ETO27688.1 - 0.017 13.3 8.8 0.024 12.8 8.8 1.2 1 0 0 1 1 1 0 DNA polymerase phi Ribosomal_60s PF00428.19 ETO27688.1 - 0.023 15.3 7.9 0.049 14.2 7.9 1.6 1 0 0 1 1 1 0 60s Acidic ribosomal protein Pes-10 PF07149.11 ETO27688.1 - 0.043 12.9 6.0 0.063 12.3 6.0 1.3 1 0 0 1 1 1 0 Pes-10 TRAP_alpha PF03896.16 ETO27688.1 - 0.1 11.7 2.6 0.14 11.3 2.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit FAM176 PF14851.6 ETO27688.1 - 0.11 12.2 5.0 0.16 11.6 5.0 1.3 1 0 0 1 1 1 0 FAM176 family GOLD_2 PF13897.6 ETO27688.1 - 0.14 12.6 1.3 0.22 12.0 1.3 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Pox_Ag35 PF03286.14 ETO27688.1 - 0.2 11.4 5.4 0.32 10.8 5.4 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein HSP90 PF00183.18 ETO27688.1 - 0.25 10.2 7.6 0.37 9.6 7.6 1.2 1 0 0 1 1 1 0 Hsp90 protein Sigma70_ner PF04546.13 ETO27688.1 - 0.35 10.7 7.3 0.56 10.0 7.3 1.3 1 0 0 1 1 1 0 Sigma-70, non-essential region Paf1 PF03985.13 ETO27688.1 - 0.6 9.0 10.4 0.78 8.7 10.4 1.1 1 0 0 1 1 1 0 Paf1 CPSF100_C PF13299.6 ETO27688.1 - 0.63 10.2 4.4 0.55 10.4 2.9 1.6 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_3_Rpc31 PF11705.8 ETO27688.1 - 0.64 10.2 11.7 0.95 9.7 11.7 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 ETO27688.1 - 0.71 8.1 7.4 0.91 7.7 7.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO27688.1 - 0.72 8.0 10.2 0.92 7.6 10.2 1.1 1 0 0 1 1 1 0 Nop14-like family RXT2_N PF08595.11 ETO27688.1 - 0.81 9.7 7.7 0.67 10.0 5.4 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal Astro_capsid_p PF12226.8 ETO27688.1 - 0.87 8.7 9.9 1.2 8.2 9.9 1.1 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NOA36 PF06524.12 ETO27688.1 - 0.98 8.7 11.9 1.4 8.2 11.9 1.1 1 0 0 1 1 1 0 NOA36 protein PAC1 PF16094.5 ETO27688.1 - 1.1 8.3 5.3 1.8 7.7 5.3 1.2 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Myc_N PF01056.18 ETO27688.1 - 1.2 9.0 6.4 1.7 8.5 6.4 1.2 1 0 0 1 1 1 0 Myc amino-terminal region PBP1_TM PF14812.6 ETO27688.1 - 3.5 8.1 6.5 6.3 7.2 6.5 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CENP-B_dimeris PF09026.10 ETO27688.1 - 4.1 7.9 15.7 7.5 7.0 15.7 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF2457 PF10446.9 ETO27688.1 - 5.5 6.0 16.7 8.3 5.4 16.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cytomega_UL84 PF06284.11 ETO27688.1 - 6 5.2 6.7 8.9 4.6 6.7 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Opi1 PF08618.10 ETO27689.1 - 0.05 12.8 1.7 0.065 12.5 1.7 1.1 1 0 0 1 1 1 0 Transcription factor Opi1 FSA_C PF10479.9 ETO27689.1 - 0.19 9.8 5.8 0.24 9.5 5.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus MAD PF05557.13 ETO27690.1 - 0.00024 19.6 11.6 0.00035 19.1 11.6 1.2 1 0 0 1 1 1 1 Mitotic checkpoint protein Atg14 PF10186.9 ETO27690.1 - 0.0036 16.4 12.0 0.006 15.7 12.0 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 SHE3 PF17078.5 ETO27690.1 - 0.0042 16.8 9.3 0.0042 16.8 9.3 2.3 1 1 1 2 2 2 2 SWI5-dependent HO expression protein 3 Chorismate_bind PF00425.18 ETO27690.1 - 0.032 13.8 1.8 0.05 13.2 1.8 1.4 1 0 0 1 1 1 0 chorismate binding enzyme BLOC1_2 PF10046.9 ETO27690.1 - 1.5 9.1 12.2 4.1 7.8 11.8 2.0 1 1 0 1 1 1 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 ATP-synt_G PF04718.15 ETO27690.1 - 2.8 8.8 4.5 2.6 8.9 0.1 2.6 2 1 1 3 3 3 0 Mitochondrial ATP synthase g subunit Metallophos PF00149.28 ETO27691.1 - 3.6e-09 37.4 3.8 6.2e-09 36.7 3.8 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO27691.1 - 0.00087 19.5 3.1 0.029 14.6 3.1 2.8 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain Pkinase PF00069.25 ETO27692.1 - 6.5e-34 117.5 0.8 6.5e-34 117.5 0.8 2.3 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27692.1 - 6.8e-26 91.1 1.1 6.8e-26 91.1 1.1 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase RIO1 PF01163.22 ETO27692.1 - 0.029 14.0 0.1 0.029 14.0 0.1 2.4 2 0 0 2 2 2 0 RIO1 family Pkinase PF00069.25 ETO27693.1 - 2.9e-17 62.9 0.0 4.1e-17 62.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PseudoU_synth_2 PF00849.22 ETO27695.1 - 4.2e-07 30.2 0.8 5.7e-07 29.7 0.8 1.2 1 0 0 1 1 1 1 RNA pseudouridylate synthase PseudoU_synth_2 PF00849.22 ETO27696.1 - 1.3e-19 70.9 0.0 5.8e-19 68.7 0.0 2.1 2 1 0 2 2 2 1 RNA pseudouridylate synthase DUF4834 PF16118.5 ETO27696.1 - 0.22 12.5 2.8 16 6.6 0.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DNA_pol_phi PF04931.13 ETO27696.1 - 9.1 4.2 9.6 16 3.5 9.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi CENP-C_C PF11699.8 ETO27698.1 - 7.5e-07 29.3 0.3 1.5e-06 28.3 0.3 1.5 1 1 0 1 1 1 1 Mif2/CENP-C like DUF1657 PF07870.11 ETO27702.1 - 0.056 13.3 0.9 0.16 11.9 0.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1657) SOGA PF11365.8 ETO27702.1 - 0.12 13.5 1.5 2.1 9.5 0.0 2.8 2 1 0 2 2 2 0 Protein SOGA TMF_TATA_bd PF12325.8 ETO27703.1 - 2.1e-07 31.1 0.7 2.1e-07 31.1 0.7 11.7 4 2 6 11 11 11 3 TATA element modulatory factor 1 TATA binding DivIC PF04977.15 ETO27703.1 - 0.00048 19.8 0.5 0.00048 19.8 0.5 14.7 7 3 7 15 15 15 5 Septum formation initiator TolA_bind_tri PF16331.5 ETO27703.1 - 0.016 15.3 0.9 0.016 15.3 0.9 12.5 8 2 5 14 14 14 0 TolA binding protein trimerisation Fez1 PF06818.15 ETO27703.1 - 0.043 14.3 0.6 0.043 14.3 0.6 8.5 2 1 5 8 8 8 0 Fez1 PT PF04886.12 ETO27704.1 - 3 7.5 22.2 1.8e+04 -4.8 22.2 4.1 1 1 0 1 1 1 0 PT repeat TSP_1 PF00090.19 ETO27705.1 - 8.2e-06 25.9 8.1 8.2e-06 25.9 8.1 2.5 1 1 1 2 2 2 1 Thrombospondin type 1 domain zf-RING_5 PF14634.6 ETO27706.1 - 9.5e-07 28.7 1.8 9.5e-07 28.7 1.8 2.0 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO27706.1 - 0.00022 21.0 4.4 0.00072 19.4 2.6 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO27706.1 - 0.00029 20.8 3.4 0.00072 19.5 3.4 1.7 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO27706.1 - 0.00059 19.6 1.9 0.00059 19.6 1.9 2.5 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO27706.1 - 0.0036 17.1 3.7 0.0036 17.1 3.7 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO27706.1 - 0.0094 16.3 4.8 0.0094 16.3 4.8 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 ETO27706.1 - 0.11 12.6 3.2 0.39 10.9 3.2 2.0 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ETO27706.1 - 0.37 10.6 4.6 0.24 11.2 2.2 2.0 2 0 0 2 2 2 0 RING-like zinc finger TPMT PF05724.11 ETO27708.1 - 6.9e-18 65.1 0.2 1.2e-11 44.7 0.0 3.1 3 0 0 3 3 3 2 Thiopurine S-methyltransferase (TPMT) Mucin PF01456.17 ETO27708.1 - 0.25 11.4 4.2 0.1 12.6 1.8 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein MecA PF05389.12 ETO27709.1 - 0.1 12.2 4.7 0.14 11.8 4.7 1.1 1 0 0 1 1 1 0 Negative regulator of genetic competence (MecA) PAT1 PF09770.9 ETO27710.1 - 3.4 5.8 21.8 6.4 4.9 21.8 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 WD40 PF00400.32 ETO27711.1 - 6.7e-57 188.1 11.1 3.4e-10 40.3 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27711.1 - 1.1e-20 73.7 1.1 0.0027 18.0 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27711.1 - 4.6e-12 45.6 0.7 0.1 11.5 0.0 5.3 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27711.1 - 8.2e-11 41.8 0.4 0.0053 16.1 0.0 3.3 1 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO27711.1 - 5.4e-09 35.2 4.1 0.53 8.9 0.0 5.1 2 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO27711.1 - 1.1e-06 28.4 8.2 2.4 8.2 0.0 5.9 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO27711.1 - 3.1e-06 27.3 4.1 1.7 8.7 0.0 4.8 2 1 2 5 5 5 2 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO27711.1 - 0.00016 21.3 2.9 0.011 15.3 0.6 2.9 1 1 0 2 2 2 1 PQQ-like domain Nbas_N PF15492.6 ETO27711.1 - 0.00074 18.9 2.6 7.9 5.7 0.1 4.9 1 1 5 6 6 6 1 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ETO27711.1 - 0.00077 18.5 2.4 0.29 10.0 0.1 4.4 1 1 4 5 5 5 1 Partner and localizer of BRCA2 WD40 domain TolB_N PF04052.13 ETO27711.1 - 0.0042 17.2 2.1 60 3.9 0.0 5.5 7 0 0 7 7 6 0 TolB amino-terminal domain Me-amine-dh_H PF06433.11 ETO27711.1 - 0.0055 15.6 0.0 0.53 9.1 0.0 3.2 2 1 3 5 5 5 2 Methylamine dehydrogenase heavy chain (MADH) DPPIV_N PF00930.21 ETO27711.1 - 0.011 14.5 0.1 0.68 8.6 0.0 3.1 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region HARP PF07443.13 ETO27711.1 - 0.015 14.9 0.1 1.1 9.0 0.0 3.3 3 1 1 4 4 3 0 HepA-related protein (HARP) SBD PF17882.1 ETO27711.1 - 0.042 13.7 0.2 4.5 7.1 0.1 2.9 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain PQQ PF01011.21 ETO27711.1 - 0.078 12.9 0.0 89 3.3 0.0 4.5 5 0 0 5 5 5 0 PQQ enzyme repeat DUF4866 PF16160.5 ETO27711.1 - 0.25 10.7 2.3 0.41 10.0 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4866) Proteasome_A_N PF10584.9 ETO27711.1 - 7.2 6.4 12.2 15 5.4 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature G-alpha PF00503.20 ETO27712.1 - 6.6e-46 157.1 14.1 1.1e-45 156.3 14.1 1.3 1 1 0 1 1 1 1 G-protein alpha subunit SBP_bac_8 PF13416.6 ETO27713.1 - 0.011 15.6 0.8 0.023 14.5 0.1 1.9 2 1 0 2 2 2 0 Bacterial extracellular solute-binding protein SBP_bac_11 PF13531.6 ETO27713.1 - 0.064 13.0 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Bacterial extracellular solute-binding protein CRAL_TRIO PF00650.20 ETO27715.1 - 4.5e-08 33.0 0.5 6.3e-08 32.5 0.5 1.2 1 0 0 1 1 1 1 CRAL/TRIO domain Tombus_P33 PF08500.10 ETO27715.1 - 0.03 14.3 0.1 0.038 13.9 0.1 1.3 1 1 0 1 1 1 0 Tombusvirus p33 Ribosomal_L6 PF00347.23 ETO27716.1 - 0.045 14.4 0.2 0.69 10.6 0.0 2.4 2 0 0 2 2 2 0 Ribosomal protein L6 Fez1 PF06818.15 ETO27717.1 - 0.0015 19.0 18.1 0.0026 18.3 18.1 1.3 1 0 0 1 1 1 1 Fez1 DUF2151 PF10221.9 ETO27717.1 - 0.047 12.3 6.1 0.046 12.3 6.1 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator Exonuc_VII_L PF02601.15 ETO27717.1 - 0.4 10.2 9.7 0.58 9.7 9.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF3435 PF11917.8 ETO27717.1 - 1.2 8.0 12.4 1.5 7.7 12.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) DUF4407 PF14362.6 ETO27717.1 - 1.7 7.9 5.4 2.4 7.4 5.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3450 PF11932.8 ETO27717.1 - 2.6 7.3 12.9 0.37 10.1 7.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) DUF1445 PF07286.12 ETO27718.1 - 0.12 12.3 0.1 0.18 11.8 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1445) Phage_C PF12025.8 ETO27720.1 - 0.055 13.3 0.1 0.14 12.0 0.1 1.6 1 0 0 1 1 1 0 Phage protein C Geminin PF07412.12 ETO27721.1 - 0.00031 20.6 6.3 0.00076 19.3 6.3 1.6 1 0 0 1 1 1 1 Geminin zf-TRAF PF02176.18 ETO27721.1 - 0.00099 19.8 5.8 0.00099 19.8 5.8 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger DUF3450 PF11932.8 ETO27721.1 - 0.53 9.6 4.9 0.9 8.8 4.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) PhoU PF01895.19 ETO27721.1 - 2.1 8.9 5.8 1.1 9.8 0.6 2.7 3 0 0 3 3 3 0 PhoU domain Secretin_N_2 PF07655.13 ETO27722.1 - 0.029 14.9 13.4 0.029 14.9 13.4 2.6 3 0 0 3 3 3 0 Secretin N-terminal domain Orf78 PF06024.12 ETO27722.1 - 0.033 14.5 5.4 0.43 10.9 4.3 2.5 2 0 0 2 2 2 0 Orf78 (ac78) DUF4834 PF16118.5 ETO27722.1 - 1.6 9.7 4.3 2.1 9.3 1.1 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Ank_4 PF13637.6 ETO27723.1 - 4.3e-18 65.4 0.2 3.1e-05 24.4 0.0 4.5 3 1 3 6 6 6 4 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO27723.1 - 2.8e-15 56.7 0.1 4e-07 30.5 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO27723.1 - 5.4e-14 52.1 0.3 7.1e-05 23.0 0.0 3.4 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO27723.1 - 4.5e-10 39.5 0.9 0.013 16.0 0.0 4.6 4 0 0 4 4 4 3 Ankyrin repeat Ank_3 PF13606.6 ETO27723.1 - 1.7e-08 34.0 0.3 0.76 10.5 0.0 4.8 5 1 0 5 5 5 3 Ankyrin repeat ABC_tran PF00005.27 ETO27725.1 - 3.2e-13 50.4 0.0 7.4e-13 49.2 0.0 1.5 1 1 0 1 1 1 1 ABC transporter FTCD PF02971.14 ETO27725.1 - 0.095 12.7 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 Formiminotransferase domain GWT1 PF06423.12 ETO27726.1 - 0.00067 19.8 0.1 0.0016 18.6 0.1 1.6 1 1 0 1 1 1 1 GWT1 DAGK_acc PF00609.19 ETO27726.1 - 0.048 14.0 2.3 0.048 14.0 0.5 1.7 1 1 1 2 2 2 0 Diacylglycerol kinase accessory domain DUF975 PF06161.11 ETO27726.1 - 0.063 13.1 0.0 0.091 12.5 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF975) DUF2951 PF11166.8 ETO27726.1 - 0.52 10.5 7.1 0.32 11.2 3.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2951) MCU PF04678.13 ETO27726.1 - 0.79 9.8 3.0 1.3 9.0 0.6 2.0 1 1 0 2 2 2 0 Mitochondrial calcium uniporter Rogdi_lz PF10259.9 ETO27728.1 - 0.017 14.6 0.1 0.035 13.5 0.1 1.5 1 0 0 1 1 1 0 Rogdi leucine zipper containing protein Phytoreo_S7 PF07236.11 ETO27728.1 - 0.02 13.3 1.0 0.035 12.5 0.2 1.7 2 0 0 2 2 2 0 Phytoreovirus S7 protein PH PF00169.29 ETO27728.1 - 0.049 14.1 0.1 0.12 12.8 0.1 1.7 1 0 0 1 1 1 0 PH domain YaeQ PF07152.12 ETO27728.1 - 0.11 12.2 0.3 0.23 11.1 0.3 1.6 1 0 0 1 1 1 0 YaeQ protein Mg296 PF09644.10 ETO27728.1 - 0.61 10.2 4.6 0.92 9.6 0.7 2.9 3 0 0 3 3 3 0 Mg296 protein DUF3405 PF11885.8 ETO27729.1 - 0.0049 15.5 0.5 0.0061 15.2 0.5 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3405) RR_TM4-6 PF06459.12 ETO27729.1 - 0.079 12.8 3.6 0.094 12.5 3.6 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO27729.1 - 0.15 10.8 0.1 0.17 10.6 0.1 1.1 1 0 0 1 1 1 0 Presenilin NHase_alpha PF02979.16 ETO27729.1 - 0.15 11.4 0.0 0.2 11.0 0.0 1.1 1 0 0 1 1 1 0 Nitrile hydratase, alpha chain V_ATPase_I PF01496.19 ETO27729.1 - 0.18 9.7 3.0 0.24 9.3 3.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CDC45 PF02724.14 ETO27729.1 - 0.25 9.6 8.2 0.3 9.3 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein RNA_pol_Rpc4 PF05132.14 ETO27729.1 - 1.3 9.5 4.8 1.7 9.1 4.8 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 PspB PF06667.12 ETO27731.1 - 0.05 13.6 0.0 0.11 12.6 0.0 1.6 1 0 0 1 1 1 0 Phage shock protein B Merozoite_SPAM PF07133.11 ETO27731.1 - 0.4 10.6 24.0 0.66 10.0 24.0 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) RasGEF PF00617.19 ETO27732.1 - 1e-12 48.6 0.8 1.3e-12 48.3 0.8 1.2 1 0 0 1 1 1 1 RasGEF domain RasGEF PF00617.19 ETO27733.1 - 4e-18 66.2 1.3 4e-18 66.2 1.3 1.5 2 0 0 2 2 2 1 RasGEF domain DUF758 PF05527.11 ETO27733.1 - 0.01 15.8 0.6 0.095 12.7 0.6 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF758) Mic1 PF07035.12 ETO27733.1 - 0.01 15.5 0.0 0.021 14.6 0.0 1.4 1 0 0 1 1 1 0 Colon cancer-associated protein Mic1-like Guanylate_cyc PF00211.20 ETO27734.1 - 0.0001 22.0 0.0 0.00015 21.5 0.0 1.2 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain WBP-1 PF11669.8 ETO27734.1 - 0.17 12.5 7.0 0.61 10.7 0.4 2.4 2 0 0 2 2 2 0 WW domain-binding protein 1 EphA2_TM PF14575.6 ETO27734.1 - 0.18 12.7 1.1 0.47 11.4 0.4 2.1 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain HemY_N PF07219.13 ETO27734.1 - 1.2 9.4 7.3 0.47 10.7 0.7 2.7 3 0 0 3 3 3 0 HemY protein N-terminus DDHD PF02862.17 ETO27735.1 - 0.00059 20.1 4.6 0.0017 18.6 4.6 1.7 1 0 0 1 1 1 1 DDHD domain CDC45 PF02724.14 ETO27735.1 - 0.00079 17.8 28.2 0.0012 17.2 28.2 1.2 1 0 0 1 1 1 1 CDC45-like protein Nop14 PF04147.12 ETO27735.1 - 0.008 14.5 43.0 0.0041 15.4 41.0 1.4 2 0 0 2 2 2 1 Nop14-like family PPP4R2 PF09184.11 ETO27735.1 - 0.019 14.6 32.0 0.038 13.6 32.0 1.5 1 0 0 1 1 1 0 PPP4R2 EF_assoc_2 PF08356.12 ETO27735.1 - 0.032 14.2 0.3 0.13 12.3 0.0 2.1 2 0 0 2 2 2 0 EF hand associated Phage_fiber_C PF06820.12 ETO27735.1 - 0.036 14.4 0.0 0.091 13.1 0.0 1.6 1 0 0 1 1 1 0 Putative prophage tail fibre C-terminus TFIIF_alpha PF05793.12 ETO27735.1 - 0.048 12.2 42.0 0.079 11.5 42.0 1.3 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) BUD22 PF09073.10 ETO27735.1 - 0.097 12.0 34.6 0.14 11.4 34.6 1.1 1 0 0 1 1 1 0 BUD22 Neur_chan_memb PF02932.16 ETO27735.1 - 0.12 12.4 4.0 0.23 11.5 4.0 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Hid1 PF12722.7 ETO27735.1 - 0.32 9.1 16.8 0.5 8.4 16.8 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF4045 PF13254.6 ETO27735.1 - 0.54 9.9 15.3 0.78 9.3 15.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) SID-1_RNA_chan PF13965.6 ETO27735.1 - 0.71 8.2 3.8 1.4 7.2 3.8 1.5 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Smg8_Smg9 PF10220.9 ETO27735.1 - 0.91 7.8 12.6 1.6 7.0 12.6 1.3 1 0 0 1 1 1 0 Smg8_Smg9 RR_TM4-6 PF06459.12 ETO27735.1 - 1.7 8.4 26.5 3.3 7.5 26.5 1.5 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO27735.1 - 2.1 7.0 20.7 3.3 6.4 20.7 1.2 1 0 0 1 1 1 0 Presenilin Mpp10 PF04006.12 ETO27735.1 - 2.5 6.4 46.2 3.6 5.9 46.2 1.1 1 0 0 1 1 1 0 Mpp10 protein Paf1 PF03985.13 ETO27735.1 - 4.6 6.1 32.5 8 5.3 32.5 1.3 1 0 0 1 1 1 0 Paf1 GAGA_bind PF06217.12 ETO27735.1 - 5.2 7.3 11.8 9.2 6.5 11.8 1.4 1 0 0 1 1 1 0 GAGA binding protein-like family SAPS PF04499.15 ETO27735.1 - 7.4 5.2 21.4 11 4.6 21.4 1.3 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Raftlin PF15250.6 ETO27735.1 - 7.6 5.2 15.7 13 4.4 15.7 1.2 1 0 0 1 1 1 0 Raftlin Mg_chelatase PF01078.21 ETO27736.1 - 0.0017 17.8 0.5 0.0029 17.0 0.5 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA PF00004.29 ETO27736.1 - 0.0093 16.4 0.4 0.0093 16.4 0.4 1.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Connexin PF00029.19 ETO27736.1 - 0.064 13.0 0.0 0.073 12.8 0.0 1.1 1 0 0 1 1 1 0 Connexin FAM176 PF14851.6 ETO27736.1 - 0.066 12.9 0.4 0.081 12.6 0.4 1.2 1 0 0 1 1 1 0 FAM176 family TniB PF05621.11 ETO27736.1 - 0.16 11.4 0.0 0.25 10.7 0.0 1.3 1 0 0 1 1 1 0 Bacterial TniB protein AAA PF00004.29 ETO27737.1 - 9.8e-29 100.5 0.1 1.7e-28 99.6 0.1 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO27737.1 - 4e-07 29.7 0.0 8.6e-07 28.7 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ETO27737.1 - 4.9e-05 23.2 0.0 9.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain PELOTA_1 PF15608.6 ETO27737.1 - 0.0099 15.7 0.1 0.041 13.8 0.1 1.9 2 0 0 2 2 2 1 PELOTA RNA binding domain Costars PF14705.6 ETO27738.1 - 1.7e-27 95.4 0.3 2e-27 95.2 0.3 1.1 1 0 0 1 1 1 1 Costars WD40 PF00400.32 ETO27739.1 - 2e-56 186.7 16.7 5e-09 36.6 0.2 8.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27739.1 - 1.3e-16 60.7 1.2 0.00055 20.2 0.0 6.7 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO27739.1 - 1.1e-08 35.0 3.3 8.9e-06 25.8 0.0 5.0 5 0 0 5 5 5 1 Kelch motif Ge1_WD40 PF16529.5 ETO27739.1 - 2.5e-08 33.3 1.9 0.3 10.0 0.1 5.4 2 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO27739.1 - 2.4e-07 30.4 3.7 0.0052 16.1 0.2 3.6 3 1 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO27739.1 - 1.9e-06 26.8 7.4 0.26 9.9 0.0 4.8 2 2 2 5 5 5 2 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO27739.1 - 7.5e-05 22.7 2.0 0.058 13.4 0.1 3.9 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Kelch_1 PF01344.25 ETO27739.1 - 0.00034 20.1 0.1 0.016 14.8 0.0 3.3 3 0 0 3 3 3 1 Kelch motif DUF5570 PF17731.1 ETO27739.1 - 0.0004 20.5 1.4 0.38 10.9 0.3 3.8 2 2 1 3 3 3 1 Family of unknown function (DUF5570) HARP PF07443.13 ETO27739.1 - 0.0016 18.0 0.0 1.8 8.2 0.0 3.4 3 0 0 3 3 3 1 HepA-related protein (HARP) Kelch_4 PF13418.6 ETO27739.1 - 0.0017 18.3 1.1 0.011 15.7 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO27739.1 - 0.013 15.4 0.3 0.19 11.7 0.1 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO27739.1 - 0.015 15.3 2.7 0.084 12.9 0.1 3.8 4 1 1 5 5 5 0 Kelch motif Cytochrom_D1 PF02239.16 ETO27739.1 - 0.027 13.0 2.2 0.33 9.4 0.2 2.9 1 1 3 4 4 4 0 Cytochrome D1 heme domain PQQ PF01011.21 ETO27739.1 - 0.16 11.9 0.2 32 4.7 0.0 3.9 4 0 0 4 4 3 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO27739.1 - 0.66 8.7 9.0 22 3.6 3.7 3.9 1 1 2 3 3 3 0 Nup133 N terminal like PPP4R2 PF09184.11 ETO27740.1 - 0.0058 16.2 9.0 0.0081 15.8 9.0 1.1 1 0 0 1 1 1 1 PPP4R2 Protocadherin PF08374.11 ETO27740.1 - 0.02 14.9 4.0 0.026 14.5 4.0 1.2 1 0 0 1 1 1 0 Protocadherin CCDC53 PF10152.9 ETO27740.1 - 0.13 12.6 6.3 0.19 12.1 6.3 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex Pkinase PF00069.25 ETO27741.1 - 3.4e-13 49.6 0.0 3.7e-13 49.4 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27741.1 - 2.7e-06 26.9 0.0 3.2e-06 26.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO27741.1 - 0.00059 19.2 0.0 0.00062 19.2 0.0 1.1 1 0 0 1 1 1 1 Kinase-like PI3Ka PF00613.20 ETO27744.1 - 1.3e-42 145.4 0.9 2.4e-42 144.4 0.9 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETO27744.1 - 1.6e-40 139.5 0.5 8.5e-39 133.9 0.5 2.7 1 1 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ETO27744.1 - 0.0093 15.9 0.0 0.028 14.4 0.0 1.9 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 GramPos_pilinD1 PF16555.5 ETO27744.1 - 0.074 13.2 0.2 0.074 13.2 0.2 2.0 2 0 0 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain Sulfotransfer_4 PF17784.1 ETO27746.1 - 0.00039 20.3 4.1 0.00056 19.8 4.1 1.6 1 1 0 1 1 1 1 Sulfotransferase domain PARP PF00644.20 ETO27749.1 - 7e-20 71.5 1.7 3.2e-13 49.7 0.0 2.8 3 1 0 3 3 3 2 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ETO27749.1 - 3e-13 50.0 0.6 5.1e-13 49.3 0.6 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain MIB_HERC2 PF06701.13 ETO27750.1 - 1.5e-05 25.2 5.4 0.0029 17.8 0.3 3.4 3 1 0 3 3 3 2 Mib_herc2 Pkinase PF00069.25 ETO27751.1 - 0.00021 20.7 0.3 0.00027 20.4 0.3 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27751.1 - 0.0092 15.3 0.2 0.012 14.9 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase UPF0258 PF06789.12 ETO27752.1 - 0.068 13.3 0.1 0.068 13.3 0.1 2.4 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0258) CMV_1a PF12467.8 ETO27752.1 - 0.43 10.9 4.2 0.21 11.9 0.3 2.3 2 1 1 3 3 3 0 Cucumber mosaic virus 1a protein family Rap_GAP PF02145.15 ETO27753.1 - 4.7e-14 52.4 0.0 6.7e-14 51.9 0.0 1.2 1 0 0 1 1 1 1 Rap/ran-GAP HEAT PF02985.22 ETO27755.1 - 3.7e-12 45.4 1.0 0.044 14.0 0.0 5.4 5 0 0 5 5 5 3 HEAT repeat Kinase-like PF14531.6 ETO27755.1 - 3.3e-05 23.3 0.0 5.4e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 Kinase-like Adaptin_N PF01602.20 ETO27755.1 - 8.3e-05 21.3 2.3 0.031 12.9 0.2 2.1 1 1 1 2 2 2 2 Adaptin N terminal region Pkinase PF00069.25 ETO27755.1 - 0.00025 20.5 0.0 0.0022 17.4 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Cnd1 PF12717.7 ETO27755.1 - 0.0038 17.3 0.9 0.06 13.4 0.3 2.6 1 1 1 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO27755.1 - 0.0068 16.8 0.0 0.78 10.2 0.0 2.7 1 1 1 2 2 2 2 HEAT repeats Pkinase_Tyr PF07714.17 ETO27755.1 - 0.045 13.0 0.0 0.073 12.3 0.0 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase HEAT_EZ PF13513.6 ETO27755.1 - 0.12 13.0 0.0 29 5.3 0.0 3.6 3 0 0 3 3 3 0 HEAT-like repeat DUF2613 PF11021.8 ETO27755.1 - 2.1 8.6 5.1 0.74 10.0 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2613) DUF4446 PF14584.6 ETO27756.1 - 1.2 9.1 4.4 1.6 8.7 0.3 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) DUF4400 PF14348.6 ETO27758.1 - 0.22 11.0 0.9 0.24 10.9 0.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4400) Sod_Fe_C PF02777.18 ETO27759.1 - 6.2e-21 74.5 1.3 1.3e-20 73.5 0.3 1.9 2 0 0 2 2 2 1 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ETO27759.1 - 2.6e-11 43.8 0.6 2.6e-11 43.8 0.6 1.9 2 1 0 2 2 2 1 Iron/manganese superoxide dismutases, alpha-hairpin domain DSPc PF00782.20 ETO27760.1 - 5.9e-16 58.5 1.1 5.9e-16 58.5 1.1 1.9 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO27760.1 - 0.00015 21.4 0.6 0.00068 19.3 0.0 2.0 2 0 0 2 2 2 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETO27760.1 - 0.0012 19.1 1.1 0.073 13.4 0.0 2.8 3 0 0 3 3 3 1 Rit1 DUSP-like domain FA_hydroxylase PF04116.13 ETO27761.1 - 4.2e-19 69.2 18.3 4.2e-19 69.2 18.3 1.5 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily UME PF08064.13 ETO27762.1 - 0.11 12.4 0.1 0.59 10.1 0.0 2.2 2 0 0 2 2 2 0 UME (NUC010) domain Peptidase_S9_N PF02897.15 ETO27763.1 - 1.4e-42 146.0 3.4 1.6e-42 145.8 3.4 1.0 1 0 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF2430 PF10353.9 ETO27763.1 - 0.099 13.0 0.0 0.14 12.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2430) DUF3188 PF11384.8 ETO27764.1 - 0.022 14.4 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) Jagunal PF07086.12 ETO27764.1 - 0.022 14.8 1.2 0.041 13.9 1.2 1.3 1 0 0 1 1 1 0 Jagunal, ER re-organisation during oogenesis P5-ATPase PF12409.8 ETO27766.1 - 0.13 12.3 0.1 0.13 12.3 0.1 2.8 4 0 0 4 4 4 0 P5-type ATPase cation transporter DNA_pol_phi PF04931.13 ETO27766.1 - 7.1 4.6 13.3 15 3.5 13.3 1.5 1 0 0 1 1 1 0 DNA polymerase phi HEAT PF02985.22 ETO27768.1 - 1.6e-06 27.8 0.6 0.48 10.8 0.0 3.8 3 1 0 3 3 3 2 HEAT repeat HEAT_2 PF13646.6 ETO27768.1 - 1.7e-05 25.1 4.2 0.0053 17.1 0.5 2.0 1 1 1 2 2 2 2 HEAT repeats DRIM PF07539.12 ETO27768.1 - 0.024 12.9 0.9 0.65 8.2 0.1 2.0 1 1 0 2 2 2 0 Down-regulated in metastasis CLASP_N PF12348.8 ETO27768.1 - 0.032 13.8 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 CLASP N terminal Kelch_4 PF13418.6 ETO27769.1 - 0.15 12.1 3.4 5.8 7.0 0.1 4.1 5 0 0 5 5 5 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO27769.1 - 0.22 11.6 0.7 2.3 8.3 0.1 2.9 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO27770.1 - 1.8e-68 224.8 21.0 6.7e-10 39.4 0.0 8.4 9 0 0 9 9 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27770.1 - 8.6e-19 67.6 6.1 0.0059 16.9 0.1 7.2 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27770.1 - 3.6e-16 59.0 1.0 0.069 12.1 0.0 7.4 2 1 6 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO27770.1 - 6.5e-09 35.8 1.3 0.00074 19.7 0.1 3.8 3 0 0 3 3 2 2 Kelch motif WD40_like PF17005.5 ETO27770.1 - 5.5e-07 29.2 4.8 0.03 13.7 0.0 4.0 1 1 3 5 5 5 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO27770.1 - 1.8e-06 26.8 2.0 0.014 13.9 0.2 2.7 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO27770.1 - 3.6e-06 25.9 12.6 0.12 11.0 0.2 5.9 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Kelch_1 PF01344.25 ETO27770.1 - 0.0031 17.1 4.4 0.43 10.2 0.1 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO27770.1 - 0.0053 16.8 0.0 0.021 14.8 0.0 2.1 1 0 0 1 1 1 1 Galactose oxidase, central domain Nbs1_C PF08599.10 ETO27770.1 - 0.0076 16.4 0.4 0.019 15.1 0.4 1.6 1 0 0 1 1 1 1 DNA damage repair protein Nbs1 PTEN_C2 PF10409.9 ETO27770.1 - 0.015 15.0 0.8 0.048 13.4 0.0 2.2 2 0 0 2 2 2 0 C2 domain of PTEN tumour-suppressor protein Phage_CI_repr PF07022.13 ETO27770.1 - 0.019 15.0 0.2 27 5.0 0.0 3.3 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain Kelch_2 PF07646.15 ETO27770.1 - 0.023 14.7 2.4 4.3 7.5 0.0 3.3 3 0 0 3 3 2 0 Kelch motif Kelch_5 PF13854.6 ETO27770.1 - 0.026 14.5 6.4 0.72 9.9 1.3 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO27770.1 - 0.065 13.5 0.5 15 6.0 0.0 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain CppA_N PF14506.6 ETO27770.1 - 0.21 11.6 1.5 3.6 7.7 1.2 2.6 2 0 0 2 2 2 0 CppA N-terminal DUF1154 PF06631.11 ETO27770.1 - 0.23 11.5 4.5 0.61 10.1 4.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF1154) zf-CCCH_4 PF18044.1 ETO27771.1 - 3.2e-07 30.0 16.5 0.00066 19.4 5.4 3.7 3 0 0 3 3 3 2 CCCH-type zinc finger zf-C3HC4 PF00097.25 ETO27771.1 - 8.6e-07 28.7 4.5 8.6e-07 28.7 4.5 3.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf_CCCH_4 PF18345.1 ETO27771.1 - 1.5e-06 28.0 15.7 0.0054 16.7 7.2 2.8 2 0 0 2 2 2 2 Zinc finger domain zf-RING_2 PF13639.6 ETO27771.1 - 2.4e-06 27.8 4.2 2.4e-06 27.8 4.2 4.3 5 1 0 5 5 3 1 Ring finger domain zf-RING_5 PF14634.6 ETO27771.1 - 6.1e-06 26.1 5.2 6.1e-06 26.1 5.2 3.7 4 0 0 4 4 3 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO27771.1 - 1.5e-05 24.9 0.3 1.5e-05 24.9 0.3 3.4 2 1 1 3 3 3 1 RING-type zinc-finger V_ATPase_I PF01496.19 ETO27771.1 - 2.5e-05 22.5 0.1 2.5e-05 22.5 0.1 1.9 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family zf-rbx1 PF12678.7 ETO27771.1 - 0.00014 22.1 4.6 0.00014 22.1 4.6 3.2 2 0 0 2 2 2 1 RING-H2 zinc finger domain Torus PF16131.5 ETO27771.1 - 0.00029 21.5 10.2 0.069 13.8 4.7 2.8 2 1 0 2 2 2 2 Torus domain Prok-RING_4 PF14447.6 ETO27771.1 - 0.0003 20.6 18.2 0.0035 17.2 5.7 4.2 3 1 1 4 4 4 2 Prokaryotic RING finger family 4 zf-CCCH PF00642.24 ETO27771.1 - 0.00035 20.4 16.8 0.0011 18.8 3.7 3.0 3 0 0 3 3 3 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-C3HC4_3 PF13920.6 ETO27771.1 - 0.0013 18.5 0.9 0.0013 18.5 0.9 4.1 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_6 PF14835.6 ETO27771.1 - 0.034 14.0 1.2 0.14 12.1 1.2 2.0 1 0 0 1 1 1 0 zf-RING of BARD1-type protein DUF3439 PF11921.8 ETO27771.1 - 0.042 13.8 1.5 0.08 12.9 1.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF5442 PF17514.2 ETO27771.1 - 0.1 12.8 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5442) zf-LITAF-like PF10601.9 ETO27771.1 - 1.3 9.3 13.2 1.2 9.5 5.7 2.8 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain zf-CCCH_2 PF14608.6 ETO27771.1 - 1.9 9.1 14.7 0.82 10.2 7.1 3.2 3 0 0 3 3 2 0 RNA-binding, Nab2-type zinc finger zf-BED PF02892.15 ETO27771.1 - 2.2 8.4 7.8 2.5 8.2 0.4 3.3 3 0 0 3 3 3 0 BED zinc finger zinc_ribbon_9 PF14369.6 ETO27771.1 - 4.6 7.6 10.0 5.3 7.4 0.6 3.2 3 0 0 3 3 3 0 zinc-ribbon DUF3377 PF11857.8 ETO27772.1 - 0.022 14.7 1.1 1.5 8.8 0.0 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) DUF308 PF03729.13 ETO27772.1 - 0.89 9.9 6.8 0.34 11.3 3.9 1.8 2 0 0 2 2 2 0 Short repeat of unknown function (DUF308) RGS PF00615.19 ETO27773.1 - 5.6e-07 29.9 0.1 1.5e-06 28.4 0.1 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain RRM_1 PF00076.22 ETO27774.1 - 0.035 13.9 0.1 0.77 9.6 0.0 2.3 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SDA1 PF05285.12 ETO27774.1 - 0.44 9.9 13.0 0.54 9.6 13.0 1.0 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.6 ETO27774.1 - 1.1 8.9 11.4 5.6 6.6 3.7 2.1 1 1 1 2 2 2 0 FAM176 family TFIIF_alpha PF05793.12 ETO27774.1 - 3.6 6.1 20.3 4.8 5.6 20.3 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RRM_1 PF00076.22 ETO27775.1 - 4.4e-14 52.1 0.0 1.1e-12 47.6 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO27775.1 - 0.0002 21.2 0.0 0.00042 20.1 0.0 1.5 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_5 PF13893.6 ETO27775.1 - 0.0018 17.9 0.1 0.003 17.1 0.1 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF3169 PF11368.8 ETO27775.1 - 0.0085 15.6 0.7 0.014 14.9 0.7 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3169) RRM_7 PF16367.5 ETO27775.1 - 0.03 14.4 0.6 5.1 7.3 0.0 3.5 3 2 0 3 3 3 0 RNA recognition motif EST1 PF10374.9 ETO27775.1 - 0.094 13.4 3.6 0.13 12.9 2.8 1.5 1 1 0 1 1 1 0 Telomerase activating protein Est1 Intg_mem_TP0381 PF09529.10 ETO27775.1 - 0.1 12.1 0.1 0.19 11.2 0.1 1.3 1 0 0 1 1 1 0 Integral membrane protein (intg_mem_TP0381) 7TM_GPCR_Srv PF10323.9 ETO27775.1 - 0.17 11.2 6.1 0.12 11.7 2.8 2.0 1 1 1 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv RSS_P20 PF11757.8 ETO27775.1 - 0.25 11.8 6.7 9.8 6.7 3.5 2.4 2 1 0 2 2 2 0 Suppressor of RNA silencing P21-like N-terminal domain DUF2681 PF10883.8 ETO27775.1 - 4.3 7.8 9.9 0.43 11.0 4.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) Mlh1_C PF16413.5 ETO27776.1 - 1.8e-42 145.6 2.7 3.8e-42 144.5 0.4 2.8 2 1 1 3 3 3 1 DNA mismatch repair protein Mlh1 C-terminus DNA_mis_repair PF01119.19 ETO27776.1 - 6.6e-24 83.9 0.9 6.4e-23 80.7 0.9 2.4 1 1 0 1 1 1 1 DNA mismatch repair protein, C-terminal domain Rsc14 PF08586.10 ETO27776.1 - 0.039 14.8 0.1 0.039 14.8 0.1 2.8 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit AAA_5 PF07728.14 ETO27777.1 - 0.012 15.6 0.0 0.04 13.9 0.0 1.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AKNA PF12443.8 ETO27777.1 - 0.1 13.3 0.4 0.34 11.6 0.1 2.0 1 1 1 2 2 2 0 AT-hook-containing transcription factor Pex24p PF06398.11 ETO27779.1 - 0.044 12.8 1.0 0.073 12.0 1.0 1.3 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin CDC50 PF03381.15 ETO27781.1 - 8.8e-08 32.0 1.8 1.9e-07 30.9 1.8 1.5 1 0 0 1 1 1 1 LEM3 (ligand-effect modulator 3) family / CDC50 family tRNA-synt_1e PF01406.19 ETO27783.1 - 2.6e-08 33.6 0.0 5.9e-08 32.4 0.0 1.6 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1 PF00133.22 ETO27783.1 - 3.5e-07 28.9 0.5 6.2e-07 28.1 0.1 1.7 2 0 0 2 2 2 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETO27783.1 - 3.7e-07 29.2 0.0 3.7e-07 29.2 0.0 2.1 2 1 0 2 2 2 1 tRNA synthetases class I (M) fn3 PF00041.21 ETO27784.1 - 1.1e-07 32.1 1.6 0.017 15.5 0.0 4.3 4 0 0 4 4 4 3 Fibronectin type III domain DUF1387 PF07139.11 ETO27785.1 - 0.008 16.0 3.5 0.0086 15.8 3.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1387) RNase_Zc3h12a PF11977.8 ETO27786.1 - 1.8e-18 66.8 0.0 4.8e-18 65.4 0.0 1.7 2 0 0 2 2 2 1 Zc3h12a-like Ribonuclease NYN domain EST1_DNA_bind PF10373.9 ETO27786.1 - 4.9e-07 29.5 1.2 1.5e-06 27.9 0.9 2.0 2 1 0 2 2 2 1 Est1 DNA/RNA binding domain PRORP PF16953.5 ETO27786.1 - 3.7e-05 23.4 0.0 0.00016 21.3 0.0 1.9 1 1 0 1 1 1 1 Protein-only RNase P DZR PF12773.7 ETO27786.1 - 0.024 14.7 1.9 0.069 13.2 1.9 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-RanBP PF00641.18 ETO27786.1 - 1.4 8.3 6.7 2.6 7.5 6.7 1.5 1 0 0 1 1 1 0 Zn-finger in Ran binding protein and others BSD PF03909.17 ETO27787.1 - 0.092 12.8 0.3 1.1 9.3 0.2 2.3 2 0 0 2 2 2 0 BSD domain zf-C2H2_4 PF13894.6 ETO27787.1 - 0.13 13.2 9.5 1.3 10.0 0.2 3.3 2 1 0 2 2 2 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO27787.1 - 0.79 10.3 9.1 7.2 7.3 4.4 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ETO27787.1 - 9.8 6.6 8.4 20 5.6 0.1 3.1 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding CDC45 PF02724.14 ETO27788.1 - 1.9 6.7 23.1 3.1 6.0 23.1 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF2981 PF11200.8 ETO27788.1 - 2.8 7.6 12.6 3.6 7.2 12.6 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) PH PF00169.29 ETO27789.1 - 4.7e-06 27.1 0.2 9.7e-06 26.0 0.2 1.5 1 1 0 1 1 1 1 PH domain PH_2 PF08458.10 ETO27789.1 - 0.028 14.8 0.0 0.043 14.2 0.0 1.4 1 0 0 1 1 1 0 Plant pleckstrin homology-like region PH_11 PF15413.6 ETO27789.1 - 0.18 12.2 1.0 0.67 10.4 1.0 1.9 1 1 0 1 1 1 0 Pleckstrin homology domain EST1 PF10374.9 ETO27790.1 - 5.4e-23 82.1 2.4 5.4e-23 82.1 2.4 1.4 2 0 0 2 2 2 1 Telomerase activating protein Est1 EST1_DNA_bind PF10373.9 ETO27790.1 - 3e-12 46.6 2.8 1e-11 44.9 0.1 2.1 2 0 0 2 2 2 1 Est1 DNA/RNA binding domain TPR_17 PF13431.6 ETO27790.1 - 0.00077 19.7 0.6 0.0025 18.1 0.0 2.3 3 0 0 3 3 3 1 Tetratricopeptide repeat Nre_N PF04894.12 ETO27790.1 - 0.021 14.7 0.1 0.028 14.3 0.1 1.1 1 0 0 1 1 1 0 Archaeal Nre, N-terminal TPR_2 PF07719.17 ETO27790.1 - 0.042 14.0 0.3 19 5.7 0.0 3.6 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27790.1 - 0.048 13.5 0.0 11 6.1 0.1 3.1 2 0 0 2 2 2 0 Tetratricopeptide repeat FliJ PF02050.16 ETO27790.1 - 1.5 9.1 8.7 0.68 10.2 0.9 3.1 3 1 0 3 3 3 0 Flagellar FliJ protein Striatin PF08232.12 ETO27791.1 - 0.021 15.4 3.6 0.021 15.4 3.6 1.7 2 0 0 2 2 2 0 Striatin family Na_K-ATPase PF00287.18 ETO27791.1 - 0.025 13.8 1.8 0.039 13.1 1.8 1.2 1 0 0 1 1 1 0 Sodium / potassium ATPase beta chain PND PF17949.1 ETO27791.1 - 0.077 13.2 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 FANCM pseudonuclease domain Orf78 PF06024.12 ETO27791.1 - 0.11 12.8 2.9 0.069 13.5 0.8 1.9 2 0 0 2 2 2 0 Orf78 (ac78) CPSF100_C PF13299.6 ETO27791.1 - 1.2 9.3 5.4 2.2 8.4 2.2 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Menin PF05053.13 ETO27791.1 - 2.3 6.4 8.5 3.5 5.9 8.5 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO27791.1 - 2.6 6.7 5.8 3.6 6.2 5.8 1.3 1 0 0 1 1 1 0 Presenilin AAR2 PF05282.11 ETO27791.1 - 3.3 7.0 10.1 4.1 6.7 10.1 1.3 1 1 0 1 1 1 0 AAR2 protein Zip PF02535.22 ETO27791.1 - 5 6.3 7.1 10 5.2 7.1 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 ETO27791.1 - 5.6 5.7 7.6 11 4.8 7.6 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter E3_binding PF02817.17 ETO27792.1 - 1.9e-14 53.7 0.1 3.4e-14 52.9 0.1 1.4 1 0 0 1 1 1 1 e3 binding domain Biotin_lipoyl PF00364.22 ETO27792.1 - 8.8e-09 35.1 0.2 0.0013 18.6 0.1 3.1 3 0 0 3 3 3 2 Biotin-requiring enzyme ThiS PF02597.20 ETO27792.1 - 0.16 12.6 0.0 0.41 11.3 0.0 1.7 2 0 0 2 2 2 0 ThiS family DUF4638 PF15472.6 ETO27794.1 - 0.26 11.0 8.4 4.4 6.9 8.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4638) AIG1 PF04548.16 ETO27795.1 - 5.3e-17 61.8 0.0 5.3e-17 61.8 0.0 2.7 3 1 1 4 4 4 1 AIG1 family MMR_HSR1 PF01926.23 ETO27795.1 - 4.1e-05 23.6 0.0 0.00018 21.5 0.0 2.2 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF2164 PF09932.9 ETO27795.1 - 0.012 15.7 0.3 8.1 6.6 0.2 3.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2164) Phage_TAC_11 PF11836.8 ETO27795.1 - 0.015 15.4 0.0 0.031 14.4 0.0 1.5 1 0 0 1 1 1 0 Phage tail tube protein, GTA-gp10 RsgA_GTPase PF03193.16 ETO27795.1 - 0.14 12.0 3.2 0.22 11.4 0.2 2.7 2 1 0 3 3 3 0 RsgA GTPase SIMPL PF04402.14 ETO27795.1 - 0.17 12.3 4.1 0.2 12.1 1.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF541) AAA_32 PF13654.6 ETO27795.1 - 0.18 10.5 14.7 0.3 9.8 14.7 1.3 1 0 0 1 1 1 0 AAA domain ABC_tran PF00005.27 ETO27795.1 - 0.31 11.5 2.5 1 9.8 0.0 2.6 2 0 0 2 2 2 0 ABC transporter Dynamin_N PF00350.23 ETO27795.1 - 0.47 10.5 0.0 0.47 10.5 0.0 3.5 2 2 0 3 3 3 0 Dynamin family ZnuA PF01297.17 ETO27795.1 - 2 7.8 6.4 2.6 7.4 5.3 1.7 2 0 0 2 2 2 0 Zinc-uptake complex component A periplasmic Peptidase_S10 PF00450.22 ETO27795.1 - 2.1 7.7 9.5 5.1 6.4 9.5 1.6 1 0 0 1 1 1 0 Serine carboxypeptidase Fringe PF02434.16 ETO27796.1 - 1.9e-05 24.3 0.0 2.6e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Fringe-like PDR_CDR PF06422.12 ETO27796.1 - 0.027 14.4 0.1 0.063 13.2 0.1 1.6 1 0 0 1 1 1 0 CDR ABC transporter Tctex-1 PF03645.13 ETO27796.1 - 0.092 13.0 0.1 0.18 12.1 0.1 1.4 1 0 0 1 1 1 0 Tctex-1 family DUF21 PF01595.20 ETO27797.1 - 1.7e-15 57.2 3.5 2.4e-15 56.7 3.5 1.2 1 0 0 1 1 1 1 Cyclin M transmembrane N-terminal domain TMEMspv1-c74-12 PF11044.8 ETO27797.1 - 1.4 9.0 5.3 7.2 6.7 0.3 2.4 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Gemini_mov PF01708.16 ETO27798.1 - 0.009 15.8 1.1 0.022 14.5 1.1 1.6 1 0 0 1 1 1 1 Geminivirus putative movement protein CBS PF00571.28 ETO27798.1 - 0.063 13.7 0.3 2.4 8.7 0.0 2.9 3 0 0 3 3 3 0 CBS domain FYRC PF05965.14 ETO27799.1 - 8.6e-05 22.6 0.1 8.6e-05 22.6 0.1 1.7 2 0 0 2 2 2 1 F/Y rich C-terminus LCD1 PF09798.9 ETO27799.1 - 0.062 11.8 1.1 0.074 11.6 1.1 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Tim54 PF11711.8 ETO27799.1 - 0.12 11.2 3.8 0.16 10.8 3.8 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Tfb4 PF03850.14 ETO27799.1 - 0.2 11.2 0.3 0.27 10.7 0.3 1.2 1 0 0 1 1 1 0 Transcription factor Tfb4 Presenilin PF01080.17 ETO27799.1 - 7.5 5.2 4.9 9.6 4.8 4.9 1.1 1 0 0 1 1 1 0 Presenilin Spem1 PF15670.5 ETO27802.1 - 0.051 13.2 3.7 0.058 13.0 1.3 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 bZIP_Maf PF03131.17 ETO27802.1 - 0.14 12.7 12.8 0.54 10.8 12.8 2.0 1 0 0 1 1 1 0 bZIP Maf transcription factor Med3 PF11593.8 ETO27802.1 - 0.27 10.4 7.2 0.55 9.4 7.2 1.4 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Orbi_VP6 PF01516.16 ETO27802.1 - 0.42 10.1 9.4 0.69 9.4 9.4 1.2 1 0 0 1 1 1 0 Orbivirus helicase VP6 PAD_M PF08527.10 ETO27802.1 - 0.59 9.8 3.3 6.4 6.4 3.6 2.6 2 0 0 2 2 2 0 Protein-arginine deiminase (PAD) middle domain SR-25 PF10500.9 ETO27802.1 - 2.6 7.6 24.9 0.63 9.6 12.1 3.0 3 0 0 3 3 3 0 Nuclear RNA-splicing-associated protein PH_10 PF15411.6 ETO27802.1 - 3.3 8.0 11.5 11 6.3 4.1 3.9 4 0 0 4 4 4 0 Pleckstrin homology domain SIT PF15330.6 ETO27802.1 - 3.5 8.1 8.4 34 4.9 0.0 3.0 3 0 0 3 3 3 0 SHP2-interacting transmembrane adaptor protein, SIT DUF3464 PF11947.8 ETO27802.1 - 5.4 6.8 7.5 13 5.5 7.5 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Sec62 PF03839.16 ETO27802.1 - 5.9 6.3 15.1 1.2 8.6 0.1 2.8 3 0 0 3 3 3 0 Translocation protein Sec62 Holin_BhlA PF10960.8 ETO27802.1 - 7.1 6.7 8.6 3.8 7.6 0.1 2.9 2 0 0 2 2 2 0 BhlA holin family Ank_2 PF12796.7 ETO27803.1 - 0.00027 21.5 0.1 0.00061 20.3 0.1 1.6 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO27803.1 - 0.0024 18.1 0.1 0.41 11.0 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO27803.1 - 0.0026 18.1 0.1 0.081 13.5 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO27803.1 - 0.0069 16.9 0.1 0.02 15.5 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO27803.1 - 0.051 14.0 0.1 0.74 10.4 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeat G-alpha PF00503.20 ETO27804.1 - 7.6e-17 61.5 0.5 1.1e-16 61.0 0.5 1.2 1 0 0 1 1 1 1 G-protein alpha subunit DUF815 PF05673.13 ETO27804.1 - 0.00043 19.5 0.1 0.0006 19.1 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO27804.1 - 0.0036 17.8 0.1 0.0082 16.7 0.1 1.6 1 1 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ETO27804.1 - 0.0053 17.1 0.0 0.0073 16.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO27804.1 - 0.0059 16.3 0.0 0.012 15.3 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_14 PF13173.6 ETO27804.1 - 0.033 14.2 0.2 0.059 13.4 0.2 1.6 1 1 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO27804.1 - 0.036 14.6 0.3 0.063 13.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO27804.1 - 0.043 14.1 0.1 0.069 13.4 0.1 1.4 1 1 0 1 1 1 0 AAA domain DLIC PF05783.11 ETO27804.1 - 0.046 12.5 0.1 0.067 12.0 0.1 1.2 1 0 0 1 1 1 0 Dynein light intermediate chain (DLIC) DAP3 PF10236.9 ETO27804.1 - 0.049 12.8 0.6 0.095 11.9 0.2 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 G-alpha PF00503.20 ETO27805.1 - 2.5e-24 86.1 9.8 1.1e-23 84.1 9.8 1.7 1 1 0 1 1 1 1 G-protein alpha subunit DUF815 PF05673.13 ETO27805.1 - 1.6e-05 24.2 0.2 3.1e-05 23.3 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF815) AAA_16 PF13191.6 ETO27805.1 - 0.0008 19.8 0.0 0.0012 19.3 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Gtr1_RagA PF04670.12 ETO27805.1 - 0.0028 17.0 0.0 0.006 16.0 0.0 1.6 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 ETO27805.1 - 0.0065 17.0 0.0 0.0095 16.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter NACHT PF05729.12 ETO27805.1 - 0.017 15.1 0.0 0.038 13.9 0.0 1.7 1 0 0 1 1 1 0 NACHT domain AAA_7 PF12775.7 ETO27805.1 - 0.032 13.7 0.2 0.091 12.3 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Roc PF08477.13 ETO27805.1 - 0.075 13.3 0.1 0.19 11.9 0.1 1.7 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase TsaE PF02367.17 ETO27805.1 - 0.098 12.7 0.1 0.2 11.7 0.1 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE VirE PF05272.11 ETO27805.1 - 0.11 12.2 1.3 0.8 9.4 0.1 2.4 1 1 1 2 2 2 0 Virulence-associated protein E MMR_HSR1 PF01926.23 ETO27805.1 - 0.12 12.5 0.0 0.25 11.4 0.0 1.7 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ETO27805.1 - 0.15 11.9 0.1 0.3 10.9 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 ETO27807.1 - 6.8e-11 42.6 6.1 2.6e-06 28.1 0.0 5.3 5 1 0 5 5 5 2 WD domain, G-beta repeat CENP-B_dimeris PF09026.10 ETO27807.1 - 0.021 15.2 2.3 0.093 13.1 0.9 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Metallophos PF00149.28 ETO27808.1 - 1.6e-09 38.6 0.1 2.1e-09 38.2 0.1 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase PUB PF09409.10 ETO27809.1 - 1.7e-06 27.8 0.0 5.2e-06 26.3 0.0 1.8 1 0 0 1 1 1 1 PUB domain TED PF08341.11 ETO27810.1 - 0.12 12.7 1.3 0.26 11.7 1.2 1.8 1 1 0 1 1 1 0 Thioester domain Sec7 PF01369.20 ETO27811.1 - 1.2e-39 135.9 3.1 2.9e-39 134.7 3.1 1.7 1 0 0 1 1 1 1 Sec7 domain DUF1981 PF09324.10 ETO27811.1 - 6.6e-28 96.4 2.7 1.8e-27 95.0 0.9 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF1981) ASH PF15780.5 ETO27812.1 - 2.7e-07 30.7 6.4 1.7 8.9 0.0 6.9 6 1 1 7 7 7 3 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin PapD-like PF14874.6 ETO27812.1 - 0.025 14.8 1.1 4.9 7.4 0.2 3.0 3 0 0 3 3 3 0 Flagellar-associated PapD-like TMEM131_like PF12371.8 ETO27812.1 - 0.042 14.1 6.1 14 6.0 0.0 6.7 8 1 0 8 8 8 0 Transmembrane protein 131-like SMP_C2CD2L PF18696.1 ETO27812.1 - 0.077 12.8 0.9 0.35 10.7 0.1 2.5 2 0 0 2 2 2 0 Synaptotagmin-like, mitochondrial and lipid-binding domain DUF711 PF05167.12 ETO27812.1 - 0.091 11.6 0.4 0.16 10.9 0.4 1.2 1 0 0 1 1 1 0 Uncharacterised ACR (DUF711) IBN_N PF03810.19 ETO27813.1 - 1.1e-08 34.8 0.3 2.8e-08 33.6 0.3 1.7 1 0 0 1 1 1 1 Importin-beta N-terminal domain ParcG PF10274.9 ETO27813.1 - 0.00053 20.2 0.1 0.0011 19.1 0.1 1.5 1 0 0 1 1 1 1 Parkin co-regulated protein UME PF08064.13 ETO27813.1 - 0.00084 19.2 1.5 0.003 17.5 0.1 2.6 3 2 1 4 4 4 1 UME (NUC010) domain HEAT_2 PF13646.6 ETO27813.1 - 0.0016 18.8 0.1 0.31 11.5 0.1 2.5 2 0 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO27813.1 - 0.0017 18.4 0.1 2.1 8.8 0.0 3.0 2 0 0 2 2 2 2 HEAT repeat DUF3385 PF11865.8 ETO27813.1 - 0.0097 15.8 0.2 0.071 13.0 0.2 2.3 1 1 0 1 1 1 1 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 ETO27813.1 - 0.017 15.7 0.1 15 6.2 0.0 3.3 2 1 1 3 3 3 0 HEAT-like repeat SseB PF07179.12 ETO27813.1 - 0.032 14.5 0.0 0.083 13.2 0.0 1.7 1 0 0 1 1 1 0 SseB protein N-terminal domain Zip PF02535.22 ETO27814.1 - 0.11 11.6 2.0 6.2 5.9 0.1 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Dicty_REP PF05086.12 ETO27814.1 - 0.8 7.6 15.7 0.21 9.6 10.5 1.9 2 0 0 2 2 2 0 Dictyostelium (Slime Mold) REP protein DUF908 PF06012.12 ETO27814.1 - 1.1 8.6 12.1 1.2 8.5 4.3 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF908) NPR3 PF03666.13 ETO27814.1 - 1.2 7.8 13.9 0.051 12.4 1.5 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CPSF100_C PF13299.6 ETO27814.1 - 1.5 9.0 9.9 4.9 7.3 2.2 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Suf PF05843.14 ETO27814.1 - 1.9 8.4 14.1 3.8 7.4 0.0 2.1 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Coilin_N PF15862.5 ETO27814.1 - 5.6 6.8 16.6 0.64 9.8 0.4 2.2 2 0 0 2 2 2 0 Coilin N-terminus dsRBD2 PF17842.1 ETO27814.1 - 7.3 6.8 10.1 0.95 9.7 0.5 2.2 2 0 0 2 2 2 0 Double-stranded RNA binding domain 2 Androgen_recep PF02166.16 ETO27814.1 - 7.9 5.2 15.4 16 4.2 15.4 1.5 1 0 0 1 1 1 0 Androgen receptor CDC14 PF08045.11 ETO27814.1 - 8.4 5.4 9.8 0.55 9.3 0.5 2.1 2 0 0 2 2 2 0 Cell division control protein 14, SIN component Med3 PF11593.8 ETO27814.1 - 8.6 5.4 34.8 0.29 10.3 16.0 2.2 2 0 0 2 2 2 0 Mediator complex subunit 3 fungal TPR_12 PF13424.6 ETO27815.1 - 8.7e-51 170.1 11.4 7.3e-16 58.2 0.3 3.8 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27815.1 - 6.5e-30 102.2 0.2 3.6e-06 26.7 0.0 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27815.1 - 7.8e-29 97.6 5.4 6.6e-05 22.7 0.0 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27815.1 - 1.2e-26 91.4 22.0 3.8e-08 32.8 0.4 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27815.1 - 1.4e-20 71.6 16.3 5.8e-05 22.9 0.2 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27815.1 - 2.1e-18 64.9 20.6 2.3e-05 24.2 0.6 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO27815.1 - 3.7e-10 39.1 3.8 0.14 11.7 0.1 4.7 5 0 0 5 5 5 3 SHNi-TPR MIT PF04212.18 ETO27815.1 - 3.3e-09 36.7 10.1 0.0024 17.9 0.2 4.2 3 1 1 4 4 4 3 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO27815.1 - 3.2e-08 33.7 0.8 5.5 7.9 0.0 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27815.1 - 2.2e-07 30.8 7.7 0.011 16.0 1.2 4.5 4 1 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27815.1 - 1.5e-06 27.8 23.5 0.028 14.1 3.5 7.0 4 3 3 7 7 6 3 TPR repeat DUF5113 PF17140.4 ETO27815.1 - 0.00013 21.9 11.5 0.53 10.1 0.2 4.1 3 1 1 4 4 4 2 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO27815.1 - 0.0013 19.4 0.0 51 5.1 0.0 4.4 4 1 1 5 5 4 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO27815.1 - 0.0026 18.4 0.0 1.3 9.8 0.0 3.7 2 2 2 4 4 4 1 Tetratricopeptide repeat DUF627 PF04781.12 ETO27815.1 - 0.0039 17.2 0.9 4.7 7.3 0.1 3.5 2 1 1 3 3 3 1 Protein of unknown function (DUF627) YflT PF11181.8 ETO27815.1 - 0.0069 16.9 1.1 1 9.9 0.3 2.7 1 1 1 2 2 2 1 Heat induced stress protein YflT DUF2225 PF09986.9 ETO27815.1 - 0.0091 15.7 7.2 6.1 6.5 7.2 2.5 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2225) NRBF2_MIT PF17169.4 ETO27815.1 - 0.037 14.3 3.7 12 6.1 0.0 3.6 3 1 1 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 Ubiq-assoc PF09145.10 ETO27815.1 - 0.065 13.2 7.0 9.8 6.3 0.2 3.8 3 0 0 3 3 3 0 Ubiquitin-associated TPR_3 PF07720.12 ETO27815.1 - 0.36 10.9 8.7 9.3 6.4 0.1 4.7 5 0 0 5 5 5 0 Tetratricopeptide repeat GRDP-like PF07173.12 ETO27817.1 - 3.4 8.3 9.2 2.5 8.8 1.5 2.4 2 0 0 2 2 2 0 Glycine-rich domain-containing protein-like Kelch_1 PF01344.25 ETO27818.1 - 3e-06 26.7 4.1 0.23 11.1 0.0 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO27818.1 - 5e-05 23.4 1.4 0.33 11.3 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO27818.1 - 6.7e-05 22.8 4.1 0.0007 19.6 0.2 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO27818.1 - 0.00055 20.1 0.0 0.0063 16.8 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO27818.1 - 0.0033 17.3 4.2 8.7 6.5 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO27818.1 - 0.22 11.6 0.8 4.2 7.5 0.0 3.4 5 0 0 5 5 5 0 Kelch motif DUF2175 PF09943.9 ETO27818.1 - 0.27 11.5 2.4 0.38 11.1 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) TPR_11 PF13414.6 ETO27820.1 - 1.1e-06 28.2 0.1 2.9e-06 26.9 0.1 1.7 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.28 ETO27820.1 - 1.8e-05 24.3 0.0 5.3e-05 22.9 0.0 1.9 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO27820.1 - 7.5e-05 23.2 0.1 0.052 14.4 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27820.1 - 0.00017 21.4 0.1 0.00097 19.1 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO27820.1 - 0.00065 20.2 0.5 0.032 14.7 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27820.1 - 0.0011 19.2 1.6 3.1 8.4 0.2 4.0 3 1 0 3 3 3 1 Tetratricopeptide repeat Cupin_8 PF13621.6 ETO27820.1 - 0.0015 18.3 0.3 0.0055 16.4 0.1 1.9 2 0 0 2 2 2 1 Cupin-like domain TPR_16 PF13432.6 ETO27820.1 - 0.0061 17.2 0.2 0.89 10.3 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27820.1 - 0.043 14.0 1.1 0.18 12.1 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat C2 PF00168.30 ETO27821.1 - 8.6e-10 38.8 0.8 8.6e-06 26.0 0.4 2.3 2 0 0 2 2 2 2 C2 domain TTL PF03133.15 ETO27822.1 - 2.4e-20 72.9 0.8 2.4e-20 72.9 0.8 1.7 2 0 0 2 2 2 1 Tubulin-tyrosine ligase family CHASE3 PF05227.13 ETO27823.1 - 1.3 9.0 10.7 0.47 10.3 2.0 2.5 2 1 0 2 2 2 0 CHASE3 domain Stathmin PF00836.19 ETO27823.1 - 4.4 7.3 17.2 0.92 9.5 5.5 2.4 2 0 0 2 2 2 0 Stathmin family PFK PF00365.20 ETO27824.1 - 0.02 14.3 0.0 0.031 13.6 0.0 1.5 1 0 0 1 1 1 0 Phosphofructokinase RuvA_N PF01330.21 ETO27824.1 - 0.038 14.1 0.0 0.1 12.7 0.0 1.7 1 0 0 1 1 1 0 RuvA N terminal domain Ribonucleas_3_3 PF14622.6 ETO27824.1 - 0.083 13.1 1.6 0.96 9.6 0.2 2.7 2 1 1 3 3 3 0 Ribonuclease-III-like Phage_GPA PF05840.13 ETO27825.1 - 0.034 13.2 2.4 0.037 13.1 2.4 1.2 1 0 0 1 1 1 0 Bacteriophage replication gene A protein (GPA) RE_Eco47II PF09553.10 ETO27825.1 - 0.22 11.1 7.6 0.3 10.7 7.6 1.2 1 0 0 1 1 1 0 Eco47II restriction endonuclease zf-CCCH PF00642.24 ETO27827.1 - 1.3e-08 34.6 19.1 1.2e-07 31.5 5.4 3.0 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO27827.1 - 1.1e-05 25.1 10.4 0.0042 16.8 4.1 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ETO27827.1 - 5.3e-05 23.5 7.4 0.097 13.2 2.0 2.4 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 ETO27827.1 - 9.9e-05 22.3 14.5 0.007 16.4 6.7 2.5 2 0 0 2 2 2 2 Zinc finger domain Torus PF16131.5 ETO27827.1 - 0.01 16.6 7.0 0.01 16.6 7.0 2.5 1 1 1 2 2 2 1 Torus domain oligo_HPY PF08352.12 ETO27827.1 - 0.47 11.0 5.2 10 6.7 0.2 2.5 2 0 0 2 2 2 0 Oligopeptide/dipeptide transporter, C-terminal region Macoilin PF09726.9 ETO27827.1 - 1.1 7.7 7.5 1.3 7.5 7.5 1.1 1 0 0 1 1 1 0 Macoilin family Spt20 PF12090.8 ETO27828.1 - 3.9e-05 23.4 8.1 3.9e-05 23.4 8.1 2.3 2 0 0 2 2 2 1 Spt20 family Tim54 PF11711.8 ETO27828.1 - 0.0021 16.9 15.1 0.017 13.9 3.0 2.1 2 0 0 2 2 2 2 Inner membrane protein import complex subunit Tim54 EPL1 PF10513.9 ETO27828.1 - 0.0066 16.9 20.8 0.021 15.2 4.3 2.1 2 0 0 2 2 2 2 Enhancer of polycomb-like TCP PF03634.13 ETO27828.1 - 0.012 16.1 5.0 0.012 16.1 5.0 2.1 2 0 0 2 2 1 0 TCP family transcription factor CLN3 PF02487.17 ETO27828.1 - 0.32 10.0 14.3 0.077 12.0 4.4 2.1 2 0 0 2 2 2 0 CLN3 protein CDC45 PF02724.14 ETO27828.1 - 0.34 9.1 14.4 0.082 11.2 1.8 2.1 2 0 0 2 2 2 0 CDC45-like protein NST1 PF13945.6 ETO27828.1 - 0.39 10.8 30.6 0.94 9.6 10.9 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator RPN2_C PF18004.1 ETO27828.1 - 0.48 10.3 27.5 2.3 8.1 8.8 2.3 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain CPSF100_C PF13299.6 ETO27828.1 - 0.49 10.5 19.2 0.44 10.7 5.1 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Dynamin_N PF00350.23 ETO27828.1 - 0.79 9.8 12.3 3.5 7.6 4.1 2.2 2 0 0 2 2 2 0 Dynamin family Vfa1 PF08432.10 ETO27828.1 - 0.83 10.0 28.5 0.98 9.7 8.7 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Connexin PF00029.19 ETO27828.1 - 0.92 9.2 19.8 0.25 11.1 4.5 2.2 2 0 0 2 2 2 0 Connexin DUF4770 PF15994.5 ETO27828.1 - 2.5 8.3 25.6 2.1 8.5 10.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4770) RPA43_OB PF17875.1 ETO27828.1 - 2.8 8.6 11.3 5.4 7.7 2.7 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Otopetrin PF03189.13 ETO27828.1 - 3 6.6 10.4 0.35 9.6 1.4 2.1 2 0 0 2 2 2 0 Otopetrin CSG2 PF16965.5 ETO27828.1 - 3.1 6.7 11.9 0.49 9.3 2.9 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 ETO27828.1 - 3.4 7.4 30.0 0.025 14.4 9.1 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RNA_pol_Rpc4 PF05132.14 ETO27828.1 - 3.7 8.0 18.8 4 7.8 5.2 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 DAG_kinase_N PF14513.6 ETO27828.1 - 4.1 7.6 17.5 0.37 11.0 3.1 2.2 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus Afi1 PF07792.12 ETO27828.1 - 4.7 7.7 22.3 9.2 6.8 9.4 2.4 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Zip PF02535.22 ETO27828.1 - 5.2 6.2 11.7 6.1 6.0 0.6 2.9 3 0 0 3 3 3 0 ZIP Zinc transporter FGF-BP1 PF06473.12 ETO27828.1 - 9.9 5.9 29.3 0.44 10.3 6.9 2.5 2 1 1 3 3 3 0 FGF binding protein 1 (FGF-BP1) PARG_cat PF05028.14 ETO27829.1 - 1.2e-65 222.0 0.5 1.2e-50 172.7 0.3 2.5 2 1 0 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) DEAD PF00270.29 ETO27831.1 - 6.6e-17 61.8 0.1 8.5e-17 61.5 0.1 1.1 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO27831.1 - 0.00058 19.9 0.0 0.00062 19.8 0.0 1.1 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit FAM176 PF14851.6 ETO27832.1 - 0.012 15.3 1.2 0.012 15.3 1.2 1.7 2 0 0 2 2 2 0 FAM176 family MAS20 PF02064.15 ETO27832.1 - 0.014 15.5 0.6 0.014 15.5 0.6 2.0 2 0 0 2 2 2 0 MAS20 protein import receptor DUF4632 PF15451.6 ETO27832.1 - 0.22 11.6 2.3 0.38 10.8 2.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4632) PvlArgDC PF01862.16 ETO27834.1 - 0.0024 17.7 0.6 0.0038 17.0 0.6 1.3 1 0 0 1 1 1 1 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC) PsbY PF06298.11 ETO27834.1 - 0.049 13.5 3.0 0.097 12.6 3.0 1.4 1 0 0 1 1 1 0 Photosystem II protein Y (PsbY) Avian_gp85 PF03708.14 ETO27834.1 - 0.072 12.3 0.2 0.087 12.0 0.2 1.1 1 0 0 1 1 1 0 Avian retrovirus envelope protein, gp85 PTR2 PF00854.21 ETO27834.1 - 0.087 11.7 0.1 0.093 11.5 0.1 1.2 1 0 0 1 1 1 0 POT family SPC12 PF06645.13 ETO27834.1 - 0.1 12.7 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Microsomal signal peptidase 12 kDa subunit (SPC12) TPR_21 PF09976.9 ETO27834.1 - 0.11 12.1 0.3 0.45 10.2 0.0 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat-like domain Dicty_REP PF05086.12 ETO27834.1 - 0.93 7.4 10.6 1 7.2 10.6 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4307 PF14155.6 ETO27834.1 - 1.7 8.5 9.5 0.26 11.1 0.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4307) RR_TM4-6 PF06459.12 ETO27834.1 - 3.2 7.5 10.3 3.8 7.2 10.3 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4750 PF15938.5 ETO27834.1 - 3.3 7.4 8.3 0.075 12.7 1.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4750) FYRC PF05965.14 ETO27835.1 - 1.3e-21 76.5 0.0 2.6e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.14 ETO27835.1 - 2.3e-15 56.1 0.1 4.1e-15 55.4 0.1 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus Spc7 PF08317.11 ETO27836.1 - 1.6e-05 24.0 14.2 2.5e-05 23.3 14.2 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein DUF3584 PF12128.8 ETO27836.1 - 1.6e-05 22.7 9.3 2.2e-05 22.2 9.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) UPF0242 PF06785.11 ETO27836.1 - 0.0007 19.8 9.0 0.0018 18.4 6.6 2.3 2 0 0 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus Leu_zip PF15294.6 ETO27836.1 - 0.0023 17.5 13.5 0.0043 16.6 13.5 1.4 1 0 0 1 1 1 1 Leucine zipper DUF1351 PF07083.11 ETO27836.1 - 0.0037 17.0 7.5 0.0061 16.4 7.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1351) DUF5082 PF16888.5 ETO27836.1 - 0.0064 16.8 16.2 0.013 15.8 14.7 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF5082) DUF2959 PF11172.8 ETO27836.1 - 0.014 15.5 6.0 0.028 14.6 6.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) DUF573 PF04504.14 ETO27836.1 - 0.016 15.9 3.0 0.57 10.9 0.5 2.8 2 0 0 2 2 2 0 Protein of unknown function, DUF573 DUF4834 PF16118.5 ETO27836.1 - 0.02 15.8 0.0 0.02 15.8 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) Mucin PF01456.17 ETO27836.1 - 0.025 14.6 24.1 0.077 13.0 15.7 2.3 2 0 0 2 2 2 0 Mucin-like glycoprotein UPF0184 PF03670.13 ETO27836.1 - 0.1 13.0 5.2 1.1 9.7 0.9 2.5 1 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) DUF1664 PF07889.12 ETO27836.1 - 0.22 11.6 11.8 1.3 9.1 5.4 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) Vps51 PF08700.11 ETO27836.1 - 0.29 11.3 8.4 3 8.0 0.4 3.2 2 1 1 3 3 3 0 Vps51/Vps67 XhlA PF10779.9 ETO27836.1 - 0.6 10.4 12.3 0.51 10.6 1.4 3.0 3 0 0 3 3 2 0 Haemolysin XhlA FlaC_arch PF05377.11 ETO27836.1 - 2.3 8.7 8.7 3.8 8.0 0.9 3.1 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) ECH_2 PF16113.5 ETO27836.1 - 3.1 7.2 7.5 4.8 6.6 7.5 1.2 1 0 0 1 1 1 0 Enoyl-CoA hydratase/isomerase SKA2 PF16740.5 ETO27836.1 - 3.9 7.3 16.7 15 5.4 4.7 2.5 1 1 1 2 2 2 0 Spindle and kinetochore-associated protein 2 FliJ PF02050.16 ETO27836.1 - 5.7 7.2 15.0 5 7.4 4.4 2.3 1 1 1 2 2 2 0 Flagellar FliJ protein RRM_1 PF00076.22 ETO27837.1 - 0.0075 16.1 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nitrophorin PF02087.15 ETO27837.1 - 0.028 14.4 0.9 0.05 13.6 0.6 1.5 1 1 0 1 1 1 0 Nitrophorin LidA_Long_CC PF18641.1 ETO27837.1 - 0.047 13.8 2.7 0.054 13.5 0.5 2.0 2 1 1 3 3 3 0 LidA long coiled-coil domain UBA_4 PF14555.6 ETO27838.1 - 4.4e-12 45.6 0.7 1.6e-11 43.9 0.4 2.1 2 0 0 2 2 2 1 UBA-like domain UBX PF00789.20 ETO27838.1 - 1.6e-07 31.4 0.1 3.7e-07 30.3 0.1 1.6 1 0 0 1 1 1 1 UBX domain TAP_C PF03943.13 ETO27838.1 - 0.073 12.7 0.6 0.21 11.3 0.6 1.8 1 0 0 1 1 1 0 TAP C-terminal domain CDC45 PF02724.14 ETO27838.1 - 0.082 11.2 8.2 0.11 10.8 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Vfa1 PF08432.10 ETO27838.1 - 0.43 10.9 12.4 0.68 10.2 12.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Atrophin-1 PF03154.15 ETO27838.1 - 6.9 4.8 9.0 9 4.4 9.0 1.2 1 0 0 1 1 1 0 Atrophin-1 family Presenilin PF01080.17 ETO27838.1 - 7.2 5.3 6.3 11 4.7 6.3 1.2 1 0 0 1 1 1 0 Presenilin MatE PF01554.18 ETO27839.1 - 0.00015 21.5 0.1 0.00021 21.0 0.1 1.2 1 0 0 1 1 1 1 MatE DUF2385 PF09539.10 ETO27839.1 - 0.14 12.6 0.0 0.42 11.2 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2385) MatE PF01554.18 ETO27840.1 - 5.8e-28 97.6 7.8 5.8e-28 97.6 7.8 2.1 2 0 0 2 2 2 1 MatE DUF5090 PF17009.5 ETO27840.1 - 7.3e-05 22.8 5.8 0.0054 16.7 0.0 2.6 2 0 0 2 2 2 2 Domain of unknown function (DUF5090) Kei1 PF08552.11 ETO27840.1 - 0.00052 19.9 1.9 0.0011 18.9 1.7 1.6 1 1 0 1 1 1 1 Inositolphosphorylceramide synthase subunit Kei1 Ndc1_Nup PF09531.10 ETO27840.1 - 0.012 14.3 0.0 0.023 13.4 0.0 1.6 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Polysacc_synt_C PF14667.6 ETO27840.1 - 0.043 13.9 0.8 0.043 13.9 0.8 3.3 2 1 1 3 3 3 0 Polysaccharide biosynthesis C-terminal domain NESP55 PF06390.12 ETO27840.1 - 0.064 12.9 1.6 0.091 12.3 1.6 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) DUF2518 PF10726.9 ETO27840.1 - 2.6 7.7 5.1 0.68 9.6 1.0 2.1 2 0 0 2 2 2 0 Protein of function (DUF2518) BSP_II PF05432.11 ETO27841.1 - 0.41 10.3 16.3 0.49 10.0 16.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Menin PF05053.13 ETO27841.1 - 0.82 8.0 9.4 0.89 7.8 9.4 1.0 1 0 0 1 1 1 0 Menin Pkinase PF00069.25 ETO27843.1 - 0.0049 16.3 0.0 0.012 15.0 0.0 1.7 1 0 0 1 1 1 1 Protein kinase domain DUF3439 PF11921.8 ETO27843.1 - 1.1 9.2 24.2 4.6 7.2 10.3 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Kelch_1 PF01344.25 ETO27844.1 - 0.00028 20.4 0.0 0.6 9.7 0.0 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO27844.1 - 0.003 17.8 0.1 12 6.3 0.0 4.1 4 0 0 4 4 4 2 Kelch motif WD40 PF00400.32 ETO27845.1 - 1.2e-46 155.7 17.5 6e-08 33.2 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27845.1 - 2.8e-20 72.4 0.6 0.00055 20.2 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27845.1 - 4.6e-15 55.4 0.7 0.0058 15.6 0.0 5.0 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO27845.1 - 3.5e-12 45.8 3.8 0.016 13.9 0.0 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO27845.1 - 2.1e-10 40.4 0.1 0.00094 18.6 0.0 3.1 1 1 2 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO27845.1 - 7.8e-07 28.0 1.4 0.016 13.8 0.0 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO27845.1 - 6.7e-05 23.0 1.9 4 7.6 0.0 4.6 1 1 4 5 5 5 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO27845.1 - 0.00011 22.0 3.9 11 6.1 0.1 5.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO27845.1 - 0.00015 21.4 0.3 0.00097 18.8 0.3 2.1 1 1 0 1 1 1 1 PQQ-like domain Utp8 PF10395.9 ETO27845.1 - 0.005 15.4 0.0 0.0064 15.1 0.0 1.2 1 0 0 1 1 1 1 Utp8 family DUF1797 PF08796.10 ETO27845.1 - 0.009 16.1 0.0 1 9.5 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1797) DPPIV_N PF00930.21 ETO27845.1 - 0.0099 14.7 0.6 0.64 8.7 0.0 3.0 2 1 1 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF2218 PF09981.9 ETO27845.1 - 0.011 16.2 0.1 10 6.6 0.0 3.8 4 0 0 4 4 4 0 Uncharacterized protein conserved in bacteria (DUF2218) PQQ PF01011.21 ETO27845.1 - 0.018 15.0 0.0 40 4.4 0.0 4.2 4 0 0 4 4 4 0 PQQ enzyme repeat DUF1513 PF07433.11 ETO27845.1 - 0.038 13.1 0.1 6.6 5.7 0.0 2.8 1 1 2 3 3 3 0 Protein of unknown function (DUF1513) Nbas_N PF15492.6 ETO27845.1 - 0.049 13.0 0.9 4.2 6.6 0.0 3.4 1 1 3 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO27845.1 - 2.5 7.9 12.0 37 4.1 0.0 5.5 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF3139 PF11337.8 ETO27846.1 - 0.34 11.6 11.1 2 9.1 0.7 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) FYVE PF01363.21 ETO27847.1 - 3.1e-12 46.5 3.4 5.8e-12 45.6 3.4 1.4 1 0 0 1 1 1 1 FYVE zinc finger FYVE_2 PF02318.16 ETO27847.1 - 0.13 12.5 11.8 0.039 14.2 7.5 2.1 2 1 0 2 2 2 0 FYVE-type zinc finger Nop14 PF04147.12 ETO27847.1 - 0.21 9.8 12.4 0.24 9.6 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family Suf PF05843.14 ETO27847.1 - 0.45 10.4 5.3 0.53 10.2 5.3 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Menin PF05053.13 ETO27847.1 - 3.5 5.9 8.6 4 5.7 8.6 1.2 1 0 0 1 1 1 0 Menin Mon1 PF03164.14 ETO27848.1 - 2.2e-62 211.4 8.8 2.8e-62 211.1 8.8 1.0 1 0 0 1 1 1 1 Trafficking protein Mon1 ETRAMP PF09716.10 ETO27848.1 - 0.032 14.3 0.7 0.032 14.3 0.7 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) CCER1 PF15482.6 ETO27848.1 - 3.8 7.3 8.5 6.4 6.6 8.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 DUF563 PF04577.14 ETO27849.1 - 5.4e-14 52.8 0.1 8.9e-14 52.1 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF563) DUF3439 PF11921.8 ETO27852.1 - 0.0091 16.0 10.5 0.021 14.8 10.5 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) Fe-ADH PF00465.19 ETO27853.1 - 2.9e-98 329.0 0.0 3.4e-98 328.8 0.0 1.0 1 0 0 1 1 1 1 Iron-containing alcohol dehydrogenase Fe-ADH_2 PF13685.6 ETO27853.1 - 3.6e-14 53.1 0.0 8.7e-09 35.4 0.0 2.9 2 1 1 3 3 3 2 Iron-containing alcohol dehydrogenase zf-C2H2_6 PF13912.6 ETO27854.1 - 0.0018 18.2 3.4 0.0061 16.5 3.4 1.9 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ETO27854.1 - 0.027 15.3 1.1 0.11 13.4 1.1 2.1 1 0 0 1 1 1 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO27854.1 - 0.046 14.2 1.0 0.14 12.6 1.0 1.9 1 0 0 1 1 1 0 Zinc finger, C2H2 type Imm5 PF14423.6 ETO27854.1 - 0.054 13.7 0.1 0.14 12.4 0.1 1.6 1 0 0 1 1 1 0 Immunity protein Imm5 zf-BED PF02892.15 ETO27854.1 - 0.11 12.5 1.0 0.39 10.8 1.0 2.1 1 0 0 1 1 1 0 BED zinc finger CMS1 PF14617.6 ETO27855.1 - 1.4e-09 37.7 0.2 1.6e-09 37.5 0.2 1.1 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit DEAD PF00270.29 ETO27855.1 - 0.0008 19.2 0.1 0.0011 18.7 0.1 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase Arena_ncap_C PF17290.2 ETO27855.1 - 0.052 12.9 0.2 0.078 12.3 0.2 1.2 1 0 0 1 1 1 0 Arenavirus nucleocapsid C-terminal domain Biopterin_H PF00351.21 ETO27856.1 - 9.6e-98 327.3 0.1 5.2e-53 180.2 0.0 2.7 2 1 1 3 3 3 2 Biopterin-dependent aromatic amino acid hydroxylase ACT PF01842.25 ETO27856.1 - 0.028 14.2 0.0 0.058 13.2 0.0 1.6 1 0 0 1 1 1 0 ACT domain MBT PF02820.18 ETO27857.1 - 0.0029 17.9 0.1 0.01 16.2 0.1 1.9 1 0 0 1 1 1 1 mbt repeat Tudor-knot PF11717.8 ETO27857.1 - 0.0086 16.0 0.3 0.023 14.6 0.3 1.8 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Methyltransf_25 PF13649.6 ETO27858.1 - 1.5e-23 83.3 0.0 3.9e-23 82.0 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO27858.1 - 3.9e-21 75.5 0.0 7.9e-21 74.5 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO27858.1 - 1.1e-19 70.8 0.1 1.5e-19 70.3 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO27858.1 - 8.5e-18 64.5 0.1 1.4e-17 63.8 0.1 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ETO27858.1 - 1.3e-10 41.4 0.0 1.8e-10 40.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO27858.1 - 4.8e-09 36.9 0.0 9.4e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETO27858.1 - 2.6e-08 33.6 0.0 3.8e-08 33.0 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase small domain RrnaAD PF00398.20 ETO27858.1 - 0.0096 15.0 0.0 0.015 14.4 0.0 1.5 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Methyltr_RsmB-F PF01189.17 ETO27858.1 - 0.011 15.4 0.0 0.019 14.6 0.0 1.4 1 0 0 1 1 1 0 16S rRNA methyltransferase RsmB/F Methyltransf_32 PF13679.6 ETO27858.1 - 0.012 15.7 0.0 0.021 14.8 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain PrmA PF06325.13 ETO27858.1 - 0.014 14.8 0.1 0.026 13.9 0.0 1.5 1 1 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 ETO27858.1 - 0.016 15.1 0.0 0.049 13.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain PCMT PF01135.19 ETO27858.1 - 0.019 14.7 0.0 0.034 13.9 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) UPF0020 PF01170.18 ETO27858.1 - 0.02 14.6 0.0 0.043 13.5 0.0 1.6 1 1 0 1 1 1 0 Putative RNA methylase family UPF0020 Methyltransf_4 PF02390.17 ETO27858.1 - 0.025 14.1 0.1 0.046 13.2 0.0 1.5 1 1 0 1 1 1 0 Putative methyltransferase GidB PF02527.15 ETO27858.1 - 0.028 13.7 0.0 0.051 12.9 0.0 1.4 1 0 0 1 1 1 0 rRNA small subunit methyltransferase G Methyltransf_15 PF09445.10 ETO27858.1 - 0.036 13.7 0.0 0.057 13.0 0.0 1.4 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase CCER1 PF15482.6 ETO27859.1 - 6.8 6.5 8.3 12 5.7 8.3 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing glutamate-rich protein family 1 PHM7_cyt PF14703.6 ETO27860.1 - 0.01 16.1 0.0 0.017 15.3 0.0 1.3 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter RSN1_TM PF13967.6 ETO27860.1 - 0.022 14.5 2.5 0.028 14.2 0.1 2.0 2 0 0 2 2 2 0 Late exocytosis, associated with Golgi transport SAM_1 PF00536.30 ETO27862.1 - 1.8e-08 34.7 0.0 4.6e-08 33.4 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO27862.1 - 9.4e-07 28.9 0.0 2.2e-06 27.7 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) EF-hand_7 PF13499.6 ETO27862.1 - 0.0016 18.9 0.6 0.0016 18.9 0.6 3.1 3 1 0 3 3 3 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO27862.1 - 0.002 17.9 0.2 1.5 8.9 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO27862.1 - 0.005 16.6 0.6 0.021 14.6 0.5 2.3 1 1 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO27862.1 - 0.009 15.5 0.4 0.33 10.6 0.1 2.7 2 0 0 2 2 2 1 EF hand DUF4549 PF15082.6 ETO27862.1 - 0.06 13.1 0.2 0.06 13.1 0.2 3.3 5 0 0 5 5 5 0 Domain of unknown function (DUF4549) DUF1980 PF09323.10 ETO27862.1 - 0.069 13.1 0.1 0.069 13.1 0.1 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF1980) Tyrosinase PF00264.20 ETO27862.1 - 0.63 10.3 10.3 1.8 8.8 0.4 2.5 2 0 0 2 2 2 0 Common central domain of tyrosinase Rhodanese PF00581.20 ETO27863.1 - 1.2e-05 25.8 0.0 2.5e-05 24.7 0.0 1.5 1 0 0 1 1 1 1 Rhodanese-like domain Cation_efflux PF01545.21 ETO27864.1 - 6.3e-26 91.3 10.5 7.6e-26 91.1 10.5 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETO27864.1 - 1.1e-08 35.1 2.0 2.1e-08 34.2 2.0 1.4 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter RabGAP-TBC PF00566.18 ETO27866.1 - 3.5e-48 164.1 6.9 3.5e-48 164.1 6.9 2.5 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Secretin_N_2 PF07655.13 ETO27866.1 - 0.0046 17.5 0.8 0.01 16.3 0.8 1.6 1 0 0 1 1 1 1 Secretin N-terminal domain Methyltransf_25 PF13649.6 ETO27867.1 - 0.043 14.5 0.0 0.27 12.0 0.0 2.4 1 0 0 1 1 1 0 Methyltransferase domain Methyltransf_12 PF08242.12 ETO27867.1 - 2.7 8.8 12.4 3.9 8.3 0.0 5.3 6 1 0 6 6 6 0 Methyltransferase domain BAR_3 PF16746.5 ETO27868.1 - 2.1e-08 34.1 3.7 2.1e-08 34.1 3.7 2.1 2 0 0 2 2 2 1 BAR domain of APPL family BAR PF03114.18 ETO27868.1 - 0.011 15.3 3.1 0.011 15.3 3.1 1.9 3 0 0 3 3 3 0 BAR domain Na_Ca_ex_C PF16494.5 ETO27868.1 - 0.079 13.4 2.3 0.59 10.6 0.5 2.9 3 0 0 3 3 3 0 C-terminal extension of sodium/calcium exchanger domain CotJB PF12652.7 ETO27868.1 - 0.22 11.7 1.0 4.6 7.5 0.0 2.9 2 1 0 2 2 2 0 CotJB protein PDR_CDR PF06422.12 ETO27868.1 - 0.39 10.6 5.1 9.9 6.2 0.1 2.4 2 0 0 2 2 2 0 CDR ABC transporter Macoilin PF09726.9 ETO27869.1 - 0.044 12.3 38.6 0.067 11.7 38.6 1.3 1 0 0 1 1 1 0 Macoilin family Dapper PF15268.6 ETO27869.1 - 0.84 8.4 28.2 1 8.1 28.2 1.1 1 0 0 1 1 1 0 Dapper SOG2 PF10428.9 ETO27869.1 - 7.1 5.7 34.1 9.1 5.3 34.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Utp14 PF04615.13 ETO27869.1 - 8 4.9 40.5 9.9 4.6 40.5 1.1 1 0 0 1 1 1 0 Utp14 protein PH_2 PF08458.10 ETO27870.1 - 0.23 11.8 3.4 0.55 10.6 0.1 2.7 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PX PF00787.24 ETO27871.1 - 9e-15 54.6 1.3 1.6e-14 53.9 1.3 1.4 1 0 0 1 1 1 1 PX domain SSP160 PF06933.11 ETO27872.1 - 1.1 7.4 10.0 1.7 6.8 10.0 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 BUD22 PF09073.10 ETO27872.1 - 4.8 6.4 24.6 11 5.2 21.0 2.2 2 0 0 2 2 2 0 BUD22 DUF3439 PF11921.8 ETO27872.1 - 5.6 7.0 12.1 16 5.5 12.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) STAS PF01740.21 ETO27873.1 - 1.6e-17 63.2 0.0 2.7e-17 62.5 0.0 1.3 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO27873.1 - 0.0021 16.9 0.1 0.0032 16.3 0.1 1.3 1 0 0 1 1 1 1 Sulfate permease family Sulfate_transp PF00916.20 ETO27874.1 - 9.6e-50 169.4 10.7 1.2e-49 169.1 10.7 1.0 1 0 0 1 1 1 1 Sulfate permease family DUF3245 PF11595.8 ETO27875.1 - 0.1 13.1 7.7 0.19 12.2 7.6 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3245) Pkinase PF00069.25 ETO27877.1 - 1.6e-69 234.2 0.0 2.6e-69 233.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO27877.1 - 3e-33 115.2 0.0 4.3e-33 114.7 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PX PF00787.24 ETO27877.1 - 5.2e-07 29.6 0.0 1.4e-06 28.2 0.0 1.8 1 0 0 1 1 1 1 PX domain Kinase-like PF14531.6 ETO27877.1 - 3.7e-06 26.5 0.0 1e-05 25.0 0.0 1.7 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ETO27877.1 - 6e-06 25.4 0.4 9.5e-06 24.8 0.4 1.2 1 0 0 1 1 1 1 Haspin like kinase domain IBR PF01485.21 ETO27877.1 - 0.00099 19.3 1.5 0.0021 18.2 1.5 1.5 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain Kdo PF06293.14 ETO27877.1 - 0.054 12.8 0.0 0.13 11.5 0.0 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ETO27877.1 - 0.095 11.7 0.1 0.21 10.6 0.0 1.5 2 0 0 2 2 2 0 Seadornavirus VP7 DUF1515 PF07439.11 ETO27878.1 - 0.021 14.8 0.1 0.051 13.6 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DUF4279 PF14106.6 ETO27878.1 - 0.15 12.2 1.4 6.3 7.0 0.2 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) Baculo_PEP_C PF04513.12 ETO27878.1 - 0.17 11.9 4.6 0.67 10.0 2.5 2.2 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus UPF0242 PF06785.11 ETO27878.1 - 3.8 7.6 14.7 4.1e+02 0.9 14.7 2.7 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Zip PF02535.22 ETO27879.1 - 0.077 12.2 0.1 0.11 11.7 0.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ETO27879.1 - 0.73 9.8 10.1 1.1 9.2 10.1 1.1 1 0 0 1 1 1 0 Protein Family FAM60A LptF_LptG PF03739.14 ETO27879.1 - 3.5 6.4 5.1 5.2 5.8 5.1 1.2 1 0 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG Presenilin PF01080.17 ETO27879.1 - 3.6 6.2 7.7 4.5 5.9 7.7 1.1 1 0 0 1 1 1 0 Presenilin T4_Rnl2_C PF18043.1 ETO27880.1 - 0.051 13.7 0.0 0.15 12.2 0.0 1.8 1 0 0 1 1 1 0 T4 RNA ligase 2 C-terminal CTNNB1_binding PF08347.11 ETO27880.1 - 0.27 11.4 7.1 0.026 14.7 2.3 1.7 2 0 0 2 2 2 0 N-terminal CTNNB1 binding F-box-like PF12937.7 ETO27881.1 - 0.016 15.1 1.0 0.024 14.5 0.1 1.8 2 0 0 2 2 2 0 F-box-like DUF4064 PF13273.6 ETO27882.1 - 0.034 14.4 0.3 0.61 10.4 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) Otopetrin PF03189.13 ETO27882.1 - 0.3 9.8 1.5 1.4 7.6 1.5 1.8 1 1 0 1 1 1 0 Otopetrin Syndecan PF01034.20 ETO27883.1 - 0.31 11.0 2.2 10 6.1 0.1 3.2 2 0 0 2 2 2 0 Syndecan domain Saf_2TM PF18303.1 ETO27883.1 - 2.7 7.5 7.5 0.66 9.6 0.5 2.8 3 0 0 3 3 3 0 SAVED-fused 2TM effector domain PAC2 PF09754.9 ETO27884.1 - 5e-10 39.8 0.0 6.9e-10 39.3 0.0 1.2 1 0 0 1 1 1 1 PAC2 family DSPc PF00782.20 ETO27884.1 - 0.047 13.5 0.0 0.11 12.3 0.0 1.6 2 0 0 2 2 2 0 Dual specificity phosphatase, catalytic domain Trypan_PARP PF05887.11 ETO27884.1 - 5.7 6.9 9.7 9.3 6.2 9.7 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) PAC2 PF09754.9 ETO27885.1 - 3e-07 30.7 0.0 3.5e-07 30.5 0.0 1.1 1 0 0 1 1 1 1 PAC2 family Pkinase PF00069.25 ETO27886.1 - 2.1e-10 40.4 0.1 5.3e-05 22.7 0.0 2.4 3 0 0 3 3 3 2 Protein kinase domain Paramyxo_ncap PF00973.19 ETO27886.1 - 0.0018 17.3 0.0 0.003 16.6 0.0 1.3 1 0 0 1 1 1 1 Paramyxovirus nucleocapsid protein Tyr_Deacylase PF02580.16 ETO27887.1 - 3.9e-24 85.8 0.0 1.8e-23 83.7 0.0 1.9 1 1 0 1 1 1 1 D-Tyr-tRNA(Tyr) deacylase Zip PF02535.22 ETO27888.1 - 0.016 14.4 3.2 0.019 14.2 3.2 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4674 PF15719.5 ETO27888.1 - 0.26 11.3 13.4 0.3 11.1 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4674) MMADHC PF10229.9 ETO27888.1 - 0.26 11.0 5.6 0.33 10.6 5.6 1.0 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein NPR3 PF03666.13 ETO27888.1 - 2.8 6.6 12.1 3.3 6.4 12.1 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Paramyxo_ncap PF00973.19 ETO27888.1 - 3.4 6.5 7.4 4.1 6.2 7.4 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein UAA PF08449.11 ETO27889.1 - 1.9e-18 66.7 2.6 3.4e-18 65.9 2.1 1.6 2 0 0 2 2 2 1 UAA transporter family EamA PF00892.20 ETO27889.1 - 0.013 15.6 4.1 0.013 15.6 4.1 2.5 2 1 0 2 2 2 0 EamA-like transporter family Ndc1_Nup PF09531.10 ETO27889.1 - 0.017 13.8 0.0 0.017 13.8 0.0 2.1 2 1 1 3 3 3 0 Nucleoporin protein Ndc1-Nup TMEM100 PF16311.5 ETO27889.1 - 0.029 14.0 8.3 0.33 10.5 0.2 3.4 3 0 0 3 3 3 0 Transmembrane protein 100 ECF_trnsprt PF12822.7 ETO27889.1 - 0.057 13.5 1.1 0.22 11.6 1.1 1.9 1 0 0 1 1 1 0 ECF transporter, substrate-specific component SieB PF14163.6 ETO27889.1 - 0.28 10.7 1.6 7.7 6.0 0.5 2.6 2 0 0 2 2 2 0 Super-infection exclusion protein B Vpu PF00558.19 ETO27889.1 - 0.41 10.4 4.3 12 5.8 0.0 3.5 4 0 0 4 4 4 0 Vpu protein DUF2681 PF10883.8 ETO27889.1 - 0.53 10.7 9.5 0.28 11.6 1.1 3.4 4 0 0 4 4 4 0 Protein of unknown function (DUF2681) DUF4271 PF14093.6 ETO27889.1 - 0.92 9.4 12.1 0.61 10.0 0.2 2.7 1 1 0 2 2 2 0 Domain of unknown function (DUF4271) LapA_dom PF06305.11 ETO27889.1 - 2.7 7.9 8.8 0.8 9.6 0.3 3.1 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain UAA PF08449.11 ETO27890.1 - 1.7e-16 60.3 14.8 3.9e-16 59.1 14.8 1.5 1 1 0 1 1 1 1 UAA transporter family TPT PF03151.16 ETO27890.1 - 0.003 16.9 7.2 0.015 14.6 2.2 2.1 1 1 0 2 2 2 2 Triose-phosphate Transporter family EamA PF00892.20 ETO27890.1 - 2.5 8.3 18.0 31 4.7 17.7 2.4 1 1 0 1 1 1 0 EamA-like transporter family TPR_12 PF13424.6 ETO27891.1 - 1e-91 301.3 17.9 2.3e-15 56.6 0.4 8.7 5 2 3 9 9 9 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27891.1 - 7e-51 168.8 9.8 0.00012 21.8 0.0 13.3 14 0 0 14 14 14 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO27891.1 - 1.4e-46 154.4 56.8 3.2e-07 29.9 0.1 14.1 14 0 0 14 14 14 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO27891.1 - 1.1e-41 137.6 40.3 2.8e-07 30.1 0.4 14.2 14 0 0 14 14 14 10 Tetratricopeptide repeat TPR_7 PF13176.6 ETO27891.1 - 4.6e-41 135.9 18.9 7.7e-05 22.5 0.2 13.0 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27891.1 - 3.5e-34 114.1 56.4 5e-06 26.3 0.8 14.2 13 1 0 13 13 13 8 Tetratricopeptide repeat TPR_11 PF13414.6 ETO27891.1 - 1.2e-14 53.6 38.6 2.4e-05 23.9 0.1 11.2 11 3 0 11 11 11 3 TPR repeat SHNi-TPR PF10516.9 ETO27891.1 - 1.1e-13 50.3 5.8 0.00079 18.8 0.0 7.3 8 0 0 8 8 8 2 SHNi-TPR TPR_16 PF13432.6 ETO27891.1 - 1.1e-11 45.2 0.0 0.011 16.4 0.0 8.9 8 3 3 11 11 9 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO27891.1 - 4.2e-11 42.7 9.3 0.96 10.2 0.1 9.9 11 0 0 11 11 10 2 Tetratricopeptide repeat SNAP PF14938.6 ETO27891.1 - 9.9e-11 41.6 13.9 2.6e-08 33.6 0.5 4.1 2 2 2 4 4 4 2 Soluble NSF attachment protein, SNAP TPR_14 PF13428.6 ETO27891.1 - 1.7e-10 40.8 0.0 0.8 10.7 0.0 8.4 9 1 1 10 10 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO27891.1 - 4.9e-10 39.1 18.2 0.84 10.2 0.2 9.6 10 0 0 10 10 10 2 Tetratricopeptide repeat Sel1 PF08238.12 ETO27891.1 - 3.3e-06 27.6 18.1 0.05 14.3 0.1 8.9 10 0 0 10 10 9 1 Sel1 repeat DUF5113 PF17140.4 ETO27891.1 - 7.5e-06 25.8 24.7 0.66 9.8 0.1 9.0 5 3 4 10 10 10 2 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETO27891.1 - 9.1e-06 25.3 0.0 0.11 11.8 0.0 3.5 2 2 2 4 4 4 2 MalT-like TPR region TPR_3 PF07720.12 ETO27891.1 - 1.1e-05 25.3 29.3 0.35 10.9 0.9 8.9 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO27891.1 - 1.9e-05 25.1 0.1 0.98 10.0 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 ETO27891.1 - 0.00021 21.3 36.6 0.014 15.5 0.6 9.7 10 1 1 11 11 11 3 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO27891.1 - 0.012 15.3 8.2 6.9 6.3 0.1 5.2 3 1 2 5 5 5 0 26S proteasome subunit RPN7 ANAPC3 PF12895.7 ETO27891.1 - 1.6 9.0 16.2 3.3 8.0 3.9 5.8 4 1 1 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF627 PF04781.12 ETO27891.1 - 2.4 8.2 7.5 12 6.0 0.2 4.4 5 2 0 5 5 4 0 Protein of unknown function (DUF627) NACHT PF05729.12 ETO27894.1 - 2.6e-18 66.5 0.2 2.6e-17 63.3 0.0 2.7 3 1 0 3 3 3 1 NACHT domain AAA_16 PF13191.6 ETO27894.1 - 0.00015 22.2 0.0 0.00041 20.8 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 ETO27894.1 - 0.0021 17.3 0.4 0.0063 15.7 0.1 2.0 2 0 0 2 2 2 1 NB-ARC domain AAA_22 PF13401.6 ETO27894.1 - 0.0036 17.6 0.1 0.026 14.8 0.1 2.5 1 1 0 1 1 1 1 AAA domain DUF87 PF01935.17 ETO27894.1 - 0.0094 16.1 0.8 0.03 14.4 0.1 2.2 2 1 1 3 3 3 1 Helicase HerA, central domain DAP3 PF10236.9 ETO27894.1 - 0.014 14.5 0.0 0.03 13.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 ABC_tran PF00005.27 ETO27894.1 - 0.021 15.4 0.0 0.12 12.9 0.0 2.2 2 0 0 2 2 2 0 ABC transporter ATPase_2 PF01637.18 ETO27894.1 - 0.023 14.6 0.0 0.063 13.2 0.0 1.8 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea NLRC4_HD2 PF17776.1 ETO27894.1 - 0.063 13.8 0.9 0.44 11.1 0.0 2.9 3 0 0 3 3 3 0 NLRC4 helical domain HD2 AAA_29 PF13555.6 ETO27894.1 - 0.099 12.4 0.0 0.31 10.8 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_14 PF13173.6 ETO27894.1 - 0.12 12.4 0.3 1.9 8.5 0.3 2.9 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO27894.1 - 0.13 11.6 0.0 0.24 10.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family RNA_helicase PF00910.22 ETO27894.1 - 0.3 11.5 2.7 0.57 10.6 0.0 3.0 4 0 0 4 4 4 0 RNA helicase TMEM132D_C PF15706.5 ETO27895.1 - 0.04 13.7 0.0 0.073 12.9 0.0 1.5 1 0 0 1 1 1 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term WD40 PF00400.32 ETO27896.1 - 4.4e-40 134.9 32.7 1.1e-06 29.2 0.2 7.4 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO27896.1 - 3.6e-17 62.2 7.8 1.6e-05 23.8 0.4 5.0 2 1 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO27896.1 - 3.1e-13 49.8 1.2 0.23 11.8 0.1 6.1 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO27896.1 - 2.7e-08 33.5 4.3 0.014 14.8 0.0 4.3 2 2 2 4 4 4 3 WD40-like domain DUF851 PF05867.11 ETO27896.1 - 0.13 11.7 0.0 1.4 8.3 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF851) WD40 PF00400.32 ETO27897.1 - 2.1e-18 66.3 7.9 6.7e-05 23.6 0.5 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27897.1 - 0.0054 17.0 0.1 5 7.5 0.0 2.9 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Bcr-Abl_Oligo PF09036.10 ETO27897.1 - 0.16 12.0 0.7 0.3 11.1 0.7 1.4 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain Med9 PF07544.13 ETO27897.1 - 0.52 10.4 4.0 0.81 9.8 3.5 1.7 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 PBP1_TM PF14812.6 ETO27898.1 - 2.4 8.6 33.5 2.4 8.6 10.7 4.1 3 1 1 4 4 4 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Env-gp36 PF09590.10 ETO27899.1 - 0.11 11.0 0.0 0.15 10.5 0.0 1.1 1 0 0 1 1 1 0 Lentivirus surface glycoprotein Pinin_SDK_memA PF04696.13 ETO27900.1 - 0.81 9.8 12.5 2.1 8.4 10.8 2.5 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region FH2 PF02181.23 ETO27904.1 - 2.2e-43 148.8 8.6 2.2e-43 148.8 8.6 2.4 2 1 0 2 2 2 1 Formin Homology 2 Domain Guanylin PF02058.15 ETO27904.1 - 0.035 14.6 0.2 0.25 11.8 0.0 2.6 2 0 0 2 2 2 0 Guanylin precursor DUF1664 PF07889.12 ETO27904.1 - 4.4 7.4 9.7 6.3 6.9 6.8 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) DFF40 PF09230.10 ETO27905.1 - 0.27 10.8 1.7 0.51 9.9 1.7 1.4 1 0 0 1 1 1 0 DNA fragmentation factor 40 kDa WD40 PF00400.32 ETO27906.1 - 1.7e-67 221.7 31.7 8.4e-10 39.1 0.0 7.9 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27906.1 - 5.8e-26 90.6 2.8 0.00074 19.8 0.1 6.6 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO27906.1 - 1.5e-13 50.4 0.3 0.03 13.3 0.0 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_C14 PF00656.22 ETO27906.1 - 1.8e-10 41.2 0.4 5.3e-10 39.7 0.2 1.9 2 0 0 2 2 2 1 Caspase domain WD40_like PF17005.5 ETO27906.1 - 6.9e-09 35.5 0.2 0.00064 19.1 0.0 3.7 4 0 0 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO27906.1 - 7.8e-08 32.1 4.4 1 9.4 0.0 6.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO27906.1 - 3.1e-07 30.5 10.8 0.49 10.5 0.0 6.4 2 1 5 7 7 7 3 Family of unknown function (DUF5570) Nup160 PF11715.8 ETO27906.1 - 4.2e-07 29.0 9.3 0.91 8.1 0.1 6.6 2 1 4 7 7 7 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO27906.1 - 0.00099 17.7 1.1 0.008 14.8 0.2 2.5 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO27906.1 - 0.0026 16.6 5.7 0.82 8.3 0.1 4.0 2 1 2 4 4 4 2 Nup133 N terminal like DUF3446 PF11928.8 ETO27906.1 - 0.016 15.5 4.8 0.041 14.2 4.8 1.7 1 0 0 1 1 1 0 Early growth response N-terminal domain Holin_BhlA PF10960.8 ETO27907.1 - 0.028 14.4 1.5 0.068 13.1 1.5 1.7 1 0 0 1 1 1 0 BhlA holin family GRIM-19 PF06212.12 ETO27907.1 - 0.045 13.7 0.2 0.1 12.6 0.2 1.6 1 0 0 1 1 1 0 GRIM-19 protein Herpes_UL17 PF04559.12 ETO27907.1 - 0.055 12.3 0.0 0.055 12.3 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus UL17 protein Ca_hom_mod PF14798.6 ETO27907.1 - 0.087 11.9 0.7 0.2 10.7 0.1 1.7 2 0 0 2 2 2 0 Calcium homeostasis modulator DUF5094 PF17015.5 ETO27907.1 - 0.35 10.9 11.5 0.57 10.3 11.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5094) 7TM_GPCR_Srv PF10323.9 ETO27907.1 - 0.7 9.2 4.6 0.3 10.4 0.6 1.9 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srv SPC25 PF06703.11 ETO27907.1 - 0.73 9.6 6.0 1.5 8.5 6.0 1.5 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) OAD_gamma PF04277.13 ETO27907.1 - 3.1 8.5 12.9 3.7 8.2 0.8 2.8 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain DUF5345 PF17280.2 ETO27908.1 - 0.12 12.3 1.5 0.33 11.0 0.0 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5345) DUF3357 PF11837.8 ETO27909.1 - 0.12 12.8 0.1 0.31 11.5 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Sporozoite_P67 PF05642.11 ETO27909.1 - 0.47 8.5 9.9 0.88 7.6 9.9 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen LAGLIDADG_WhiA PF14527.6 ETO27910.1 - 0.06 13.4 0.2 0.23 11.6 0.2 2.0 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain DUF98 PF01947.16 ETO27910.1 - 2.4 8.1 6.3 2.1 8.3 0.1 3.0 3 0 0 3 3 3 0 p-hydroxybenzoic acid synthase DSHCT PF08148.12 ETO27911.1 - 3.2e-41 140.7 0.5 3.2e-41 140.7 0.5 1.8 2 0 0 2 2 2 1 DSHCT (NUC185) domain ABC_tran_CTD PF16326.5 ETO27911.1 - 0.73 10.1 3.8 1.4 9.2 1.6 2.6 2 0 0 2 2 2 0 ABC transporter C-terminal domain DEAD PF00270.29 ETO27912.1 - 4.5e-11 42.8 0.1 2.6e-10 40.3 0.0 2.2 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO27912.1 - 1.7e-07 31.5 0.1 2.7e-06 27.7 0.0 3.1 3 1 0 3 3 3 1 Helicase conserved C-terminal domain ResIII PF04851.15 ETO27912.1 - 0.003 17.6 0.2 0.003 17.6 0.2 2.0 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit IstB_IS21 PF01695.17 ETO27912.1 - 0.0081 15.9 0.0 0.016 15.0 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein rRNA_proc-arch PF13234.6 ETO27912.1 - 0.019 14.9 1.6 0.019 14.9 1.6 2.0 2 0 0 2 2 2 0 rRNA-processing arch domain PhoH PF02562.16 ETO27912.1 - 0.045 13.2 0.0 0.083 12.3 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein ATPase_2 PF01637.18 ETO27912.1 - 0.05 13.5 0.0 0.15 12.0 0.0 1.8 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Fascin PF06268.13 ETO27913.1 - 0.018 15.2 0.3 0.17 12.2 0.0 2.4 2 0 0 2 2 2 0 Fascin domain mRNA_cap_C PF03919.15 ETO27913.1 - 0.064 13.9 3.2 0.31 11.7 2.0 2.6 2 0 0 2 2 2 0 mRNA capping enzyme, C-terminal domain Connexin PF00029.19 ETO27913.1 - 0.072 12.8 0.2 0.072 12.8 0.2 2.5 2 1 0 2 2 2 0 Connexin CDC45 PF02724.14 ETO27913.1 - 0.082 11.2 12.0 0.033 12.5 4.1 2.1 2 0 0 2 2 2 0 CDC45-like protein TPR_1 PF00515.28 ETO27913.1 - 0.097 12.5 5.6 1 9.3 0.0 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat FAM176 PF14851.6 ETO27913.1 - 0.11 12.1 8.6 1.6 8.4 3.9 2.5 2 0 0 2 2 2 0 FAM176 family Zip PF02535.22 ETO27913.1 - 0.14 11.3 1.1 1 8.5 0.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter TPR_7 PF13176.6 ETO27913.1 - 0.19 11.8 0.7 8.7 6.6 0.0 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat Rpn3_C PF08375.11 ETO27913.1 - 0.24 11.8 0.2 0.24 11.8 0.2 3.5 2 1 1 3 3 2 0 Proteasome regulatory subunit C-terminal Afi1 PF07792.12 ETO27913.1 - 0.3 11.6 16.8 0.34 11.4 1.1 3.2 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CPSF100_C PF13299.6 ETO27913.1 - 0.31 11.2 5.8 19 5.4 1.7 3.1 3 0 0 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal TPR_12 PF13424.6 ETO27913.1 - 1.1 9.6 6.8 2.4 8.5 3.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat RNA_pol_Rpc4 PF05132.14 ETO27913.1 - 1.6 9.2 5.3 23 5.4 0.1 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 Adaptin_binding PF10199.9 ETO27913.1 - 1.9 9.1 15.8 4.1 8.0 6.8 2.5 2 0 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 RXT2_N PF08595.11 ETO27913.1 - 2 8.4 13.0 4.6 7.3 7.4 2.5 2 0 0 2 2 2 0 RXT2-like, N-terminal PBP1_TM PF14812.6 ETO27913.1 - 4.2 7.8 16.4 1 9.8 8.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PTPRCAP PF15713.5 ETO27913.1 - 4.6 7.5 14.3 20 5.4 0.0 3.1 3 0 0 3 3 3 0 Protein tyrosine phosphatase receptor type C-associated DUF3464 PF11947.8 ETO27913.1 - 6.5 6.5 6.0 14 5.4 0.1 2.7 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 TPR_1 PF00515.28 ETO27914.1 - 0.00054 19.7 1.8 0.14 12.0 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO27914.1 - 0.0034 17.5 1.8 0.034 14.3 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO27914.1 - 0.0036 17.6 1.8 0.018 15.3 1.8 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO27914.1 - 0.0072 16.8 0.0 0.012 16.1 0.0 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO27914.1 - 0.0081 16.4 0.5 0.016 15.4 0.4 1.6 1 1 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETO27914.1 - 0.037 14.1 1.9 0.19 11.9 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO27914.1 - 0.19 11.8 4.5 1.7 8.7 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO27914.1 - 0.25 11.3 2.0 0.72 9.8 0.1 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat Glyco_hydro_92 PF07971.12 ETO27915.1 - 2.4e-36 125.7 0.5 2.7e-36 125.5 0.5 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 Glyco_hydro_92 PF07971.12 ETO27916.1 - 2.2e-77 260.9 0.4 6e-77 259.5 0.2 1.7 2 0 0 2 2 2 1 Glycosyl hydrolase family 92 Glyco_hydro_92N PF17678.1 ETO27916.1 - 1.1e-54 185.8 4.1 2.1e-54 185.0 4.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolase family 92 N-terminal domain Med2 PF11214.8 ETO27916.1 - 0.041 14.0 0.2 0.081 13.1 0.2 1.5 1 0 0 1 1 1 0 Mediator complex subunit 2 Prp18 PF02840.15 ETO27917.1 - 0.069 13.2 0.1 0.11 12.6 0.1 1.4 1 0 0 1 1 1 0 Prp18 domain PknG_TPR PF16918.5 ETO27917.1 - 0.093 11.4 0.0 0.12 11.1 0.0 1.1 1 0 0 1 1 1 0 Protein kinase G tetratricopeptide repeat Sec16_C PF12931.7 ETO27918.1 - 6.9e-06 25.9 0.2 1e-05 25.4 0.2 1.2 1 0 0 1 1 1 1 Sec23-binding domain of Sec16 2OG-FeII_Oxy_3 PF13640.6 ETO27919.1 - 5.8e-13 49.6 0.2 1e-12 48.8 0.2 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 ETO27919.1 - 1.3e-05 24.5 0.0 2.5e-05 23.5 0.0 1.4 1 1 0 1 1 1 1 Poxvirus C4/C10 protein F-box-like PF12937.7 ETO27919.1 - 0.029 14.2 0.4 0.065 13.1 0.4 1.6 1 0 0 1 1 1 0 F-box-like LCD1 PF09798.9 ETO27920.1 - 1.1 7.7 20.2 1.8 7.0 20.2 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein RP-C_C PF11800.8 ETO27920.1 - 2.1 8.4 14.0 0.23 11.6 9.4 1.8 2 0 0 2 2 2 0 Replication protein C C-terminal region Exonuc_VII_L PF02601.15 ETO27920.1 - 3.4 7.2 9.7 5.9 6.4 9.7 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit MIB_HERC2 PF06701.13 ETO27921.1 - 2e-34 117.6 34.3 1.9e-20 72.9 4.6 5.3 5 1 0 5 5 5 4 Mib_herc2 RR_TM4-6 PF06459.12 ETO27921.1 - 0.067 13.0 4.3 0.11 12.3 4.3 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 ETO27921.1 - 0.13 10.5 12.4 0.18 10.0 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family PTPRCAP PF15713.5 ETO27921.1 - 0.34 11.2 16.9 0.78 10.0 16.9 1.5 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 ETO27921.1 - 0.47 8.7 14.6 0.66 8.2 14.6 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF913 PF06025.12 ETO27921.1 - 0.64 8.9 1.7 0.91 8.4 1.7 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF3304 PF11745.8 ETO27921.1 - 0.68 10.4 6.5 17 5.8 5.4 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF3304) FAM176 PF14851.6 ETO27921.1 - 0.72 9.5 12.6 1.7 8.3 12.6 1.6 1 0 0 1 1 1 0 FAM176 family CPSF100_C PF13299.6 ETO27921.1 - 0.72 10.0 3.9 1.5 8.9 3.9 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CDC27 PF09507.10 ETO27921.1 - 0.78 9.1 14.1 1.2 8.4 14.1 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 RPA43_OB PF17875.1 ETO27921.1 - 1.2 9.8 5.4 3.1 8.4 5.4 1.8 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I NOA36 PF06524.12 ETO27921.1 - 1.3 8.3 15.2 0.49 9.7 12.8 1.4 2 0 0 2 2 2 0 NOA36 protein Vfa1 PF08432.10 ETO27921.1 - 5.6 7.3 16.9 11 6.3 16.9 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RXT2_N PF08595.11 ETO27921.1 - 5.8 6.9 12.9 11 6.1 12.9 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal TLP-20 PF06088.11 ETO27921.1 - 8.7 6.2 11.9 4.6 7.1 8.9 2.0 3 0 0 3 3 3 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Nucleo_P87 PF07267.11 ETO27921.1 - 9.2 5.0 8.9 13 4.5 8.9 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Mito_carr PF00153.27 ETO27923.1 - 1.9e-06 27.7 0.1 0.022 14.7 0.0 2.3 2 1 0 2 2 2 2 Mitochondrial carrier protein GREB1 PF15782.5 ETO27924.1 - 3.3 4.7 13.3 4.1 4.4 13.3 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Pescadillo_N PF06732.11 ETO27925.1 - 3e-34 118.8 3.0 9.5e-34 117.2 3.0 1.9 1 0 0 1 1 1 1 Pescadillo N-terminus BRCT_2 PF16589.5 ETO27925.1 - 6.7e-08 32.8 2.7 3.8e-07 30.4 0.0 3.0 3 0 0 3 3 3 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETO27925.1 - 0.00022 21.5 2.9 0.0027 18.1 0.0 4.0 4 1 0 4 4 4 1 BRCA1 C Terminus (BRCT) domain RGS PF00615.19 ETO27926.1 - 2.8e-13 50.2 4.3 2.8e-13 50.2 4.3 1.6 2 0 0 2 2 2 1 Regulator of G protein signaling domain BSP_II PF05432.11 ETO27926.1 - 0.2 11.3 29.6 0.22 11.2 18.7 2.1 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) DUF3824 PF12868.7 ETO27926.1 - 0.29 11.8 7.2 0.53 10.9 0.3 2.4 2 0 0 2 2 2 0 Domain of unknwon function (DUF3824) Tim54 PF11711.8 ETO27926.1 - 0.52 9.0 9.7 0.28 9.9 2.5 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Cwf_Cwc_15 PF04889.12 ETO27926.1 - 2.5 7.8 27.3 2 8.1 16.9 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein XAP5 PF04921.14 ETO27927.1 - 0.031 14.1 0.0 0.031 14.1 0.0 3.2 3 1 0 3 3 3 0 XAP5, circadian clock regulator Guanylate_cyc PF00211.20 ETO27927.1 - 0.092 12.4 0.0 0.18 11.4 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain Sec62 PF03839.16 ETO27927.1 - 1.7 8.1 5.9 0.24 10.9 0.3 2.1 2 0 0 2 2 2 0 Translocation protein Sec62 LEF-9 PF05094.12 ETO27929.1 - 0.0012 17.5 0.2 0.0014 17.3 0.2 1.1 1 0 0 1 1 1 1 Late expression factor 9 (LEF-9) C2 PF00168.30 ETO27930.1 - 4.1e-08 33.5 0.3 9.1e-08 32.3 0.2 1.6 1 1 1 2 2 2 1 C2 domain UCH PF00443.29 ETO27931.1 - 9.1e-34 117.1 0.5 9.1e-34 117.1 0.5 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO27931.1 - 9.4e-16 58.3 0.2 9.4e-16 58.3 0.2 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase NOB1_Zn_bind PF08772.11 ETO27931.1 - 0.077 13.2 0.4 0.077 13.2 0.4 1.8 2 0 0 2 2 2 0 Nin one binding (NOB1) Zn-ribbon like Peptidase_C98 PF15499.6 ETO27931.1 - 0.27 10.7 3.1 0.4 10.1 2.3 1.7 1 1 1 2 2 2 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase DUF2615 PF11027.8 ETO27932.1 - 0.00024 21.2 1.0 0.00024 21.2 1.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF2615) DUF4366 PF14283.6 ETO27932.1 - 0.001 19.1 6.8 0.001 19.1 6.8 2.8 2 1 1 3 3 3 1 Domain of unknown function (DUF4366) SARAF PF06682.12 ETO27932.1 - 0.0027 17.4 3.1 0.0027 17.4 3.1 1.6 2 0 0 2 2 1 1 SOCE-associated regulatory factor of calcium homoeostasis O-ag_pol_Wzy PF14296.6 ETO27932.1 - 0.0033 16.2 5.3 0.0048 15.6 5.3 1.2 1 0 0 1 1 1 1 O-antigen polysaccharide polymerase Wzy DUF4611 PF15387.6 ETO27932.1 - 0.0045 17.2 6.9 0.28 11.4 5.4 2.7 2 0 0 2 2 2 1 Domain of unknown function (DUF4611) DUF2207 PF09972.9 ETO27932.1 - 0.0069 15.2 0.4 0.012 14.4 0.4 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) BatD PF13584.6 ETO27932.1 - 0.0071 15.2 2.3 0.01 14.7 2.3 1.2 1 0 0 1 1 1 1 Oxygen tolerance TMEM154 PF15102.6 ETO27932.1 - 0.0083 16.0 4.7 0.0083 16.0 4.7 2.3 2 0 0 2 2 2 1 TMEM154 protein family DUF5305 PF17231.2 ETO27932.1 - 0.014 14.8 5.4 0.028 13.8 5.4 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5305) Orf78 PF06024.12 ETO27932.1 - 0.019 15.2 1.3 0.019 15.2 1.3 3.1 3 1 1 4 4 2 0 Orf78 (ac78) DUF5058 PF16481.5 ETO27932.1 - 0.029 14.1 2.3 0.052 13.2 2.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5058) Dpy19 PF10034.9 ETO27932.1 - 0.043 12.0 0.8 0.074 11.3 0.8 1.5 1 0 0 1 1 1 0 Q-cell neuroblast polarisation DcuA_DcuB PF03605.14 ETO27932.1 - 0.083 11.8 2.5 0.13 11.1 2.5 1.3 1 0 0 1 1 1 0 Anaerobic c4-dicarboxylate membrane transporter Glt_symporter PF03616.14 ETO27932.1 - 0.094 11.4 3.2 0.18 10.5 3.2 1.5 1 0 0 1 1 1 0 Sodium/glutamate symporter 7TM_GPCR_Srx PF10328.9 ETO27932.1 - 0.11 12.1 4.4 0.19 11.3 4.4 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srx DUF979 PF06166.12 ETO27932.1 - 0.11 11.6 1.1 0.18 11.0 1.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF979) Fer4_18 PF13746.6 ETO27932.1 - 0.11 12.6 0.3 0.11 12.6 0.3 4.4 4 2 2 6 6 4 0 4Fe-4S dicluster domain Baculo_11_kDa PF06143.11 ETO27932.1 - 0.13 11.8 1.7 0.43 10.2 1.7 1.9 1 0 0 1 1 1 0 Baculovirus 11 kDa family MFS_2 PF13347.6 ETO27932.1 - 0.18 10.3 0.2 0.25 9.9 0.2 1.1 1 0 0 1 1 1 0 MFS/sugar transport protein 7TM_GPCR_Srv PF10323.9 ETO27932.1 - 0.24 10.7 3.3 0.43 9.9 3.3 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srv 7tm_6 PF02949.20 ETO27932.1 - 0.25 10.4 2.2 0.9 8.6 0.0 2.3 3 0 0 3 3 3 0 7tm Odorant receptor DUF4448 PF14610.6 ETO27932.1 - 0.33 10.7 6.1 0.96 9.2 4.5 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4448) CENP-B_dimeris PF09026.10 ETO27932.1 - 0.42 11.0 3.6 0.47 10.9 0.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Gaa1 PF04114.14 ETO27932.1 - 0.49 9.4 1.8 0.79 8.7 1.8 1.2 1 0 0 1 1 1 0 Gaa1-like, GPI transamidase component SID-1_RNA_chan PF13965.6 ETO27932.1 - 1.2 7.5 6.5 0.22 9.9 2.7 1.7 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 CSG2 PF16965.5 ETO27932.1 - 2.7 6.9 7.7 0.47 9.3 3.8 1.7 2 0 0 2 2 2 0 Ceramide synthase regulator SspB PF04386.13 ETO27932.1 - 2.8 7.8 9.0 2.1 8.2 6.1 2.1 2 0 0 2 2 2 0 Stringent starvation protein B 7TM_GPCR_Sru PF10322.9 ETO27932.1 - 4.4 6.5 11.7 1.1 8.5 8.6 1.5 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Sru TMEM51 PF15345.6 ETO27932.1 - 5.5 6.8 13.1 0.37 10.6 7.2 1.9 2 0 0 2 2 2 0 Transmembrane protein 51 zf-HC5HC2H PF13771.6 ETO27933.1 - 4.7e-12 46.0 8.2 4.7e-12 46.0 8.2 2.4 2 0 0 2 2 2 1 PHD-like zinc-binding domain zf-HC5HC2H_2 PF13832.6 ETO27933.1 - 4.3e-11 42.9 10.4 6.5e-11 42.4 7.5 2.3 2 0 0 2 2 2 1 PHD-zinc-finger like domain Pertus-S4-tox PF09275.10 ETO27933.1 - 0.068 13.5 0.0 0.11 12.8 0.0 1.4 1 0 0 1 1 1 0 Pertussis toxin S4 subunit AAA PF00004.29 ETO27934.1 - 5.1e-42 143.4 0.0 2.8e-40 137.8 0.0 2.8 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO27934.1 - 2.2e-06 28.0 1.1 0.00019 21.7 0.1 3.3 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO27934.1 - 4.4e-06 26.7 0.0 1e-05 25.5 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETO27934.1 - 8.3e-06 26.0 0.1 4.9e-05 23.5 0.0 2.2 2 1 0 2 2 1 1 AAA domain (Cdc48 subfamily) AAA_lid_3 PF17862.1 ETO27934.1 - 2.8e-05 23.8 0.0 5.7e-05 22.8 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain AAA_16 PF13191.6 ETO27934.1 - 8.9e-05 22.9 0.2 0.0019 18.6 0.0 2.8 2 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ETO27934.1 - 0.00023 21.5 0.0 0.0009 19.6 0.0 2.0 1 1 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 ETO27934.1 - 0.00056 19.5 0.0 0.0014 18.2 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_14 PF13173.6 ETO27934.1 - 0.0016 18.5 0.0 0.0052 16.8 0.0 1.9 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETO27934.1 - 0.0019 18.0 0.0 0.0093 15.7 0.0 2.0 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_11 PF13086.6 ETO27934.1 - 0.0027 17.5 1.1 0.01 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ETO27934.1 - 0.003 17.7 0.0 0.013 15.6 0.0 2.1 2 0 0 2 2 2 1 AAA domain ResIII PF04851.15 ETO27934.1 - 0.0055 16.7 2.6 0.016 15.2 0.0 2.8 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ETO27934.1 - 0.0075 15.5 0.3 0.025 13.8 0.0 1.9 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) NACHT PF05729.12 ETO27934.1 - 0.011 15.6 0.5 0.068 13.1 0.0 2.7 2 1 0 2 2 2 0 NACHT domain AFG1_ATPase PF03969.16 ETO27934.1 - 0.025 13.5 0.0 0.067 12.1 0.0 1.7 1 0 0 1 1 1 0 AFG1-like ATPase DAP3 PF10236.9 ETO27934.1 - 0.034 13.3 0.1 0.18 10.9 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial ribosomal death-associated protein 3 AAA_30 PF13604.6 ETO27934.1 - 0.05 13.3 0.0 0.093 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_3 PF07726.11 ETO27934.1 - 0.061 13.2 0.0 0.57 10.0 0.0 2.7 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO27934.1 - 0.07 13.7 0.0 0.26 11.8 0.0 2.1 2 0 0 2 2 1 0 AAA domain Mg_chelatase PF01078.21 ETO27934.1 - 0.082 12.3 0.1 0.15 11.4 0.1 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Guanylate_kin PF00625.21 ETO27934.1 - 0.085 12.5 0.1 0.57 9.8 0.0 2.2 2 0 0 2 2 2 0 Guanylate kinase AAA_19 PF13245.6 ETO27934.1 - 0.093 13.1 0.0 0.34 11.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain TsaE PF02367.17 ETO27934.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 ETO27934.1 - 0.17 12.1 0.0 0.7 10.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain PIP5K PF01504.18 ETO27935.1 - 1.9e-25 89.6 0.0 5.7e-25 88.1 0.0 1.7 1 1 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase SAM_1 PF00536.30 ETO27937.1 - 3.7e-07 30.5 0.2 9.6e-07 29.2 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO27937.1 - 4.8e-06 26.6 0.1 1.2e-05 25.3 0.1 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PRIMA1 PF16101.5 ETO27938.1 - 5.1 7.2 7.0 13 5.8 4.4 2.9 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 FSA_C PF10479.9 ETO27939.1 - 0.23 9.6 6.5 0.29 9.2 6.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Arabinose_trans PF04602.12 ETO27939.1 - 0.28 10.0 3.4 0.43 9.4 3.4 1.2 1 0 0 1 1 1 0 Mycobacterial cell wall arabinan synthesis protein RNA_pol_Rpb1_5 PF04998.17 ETO27940.1 - 1.8e-81 273.5 0.3 2.5e-81 273.0 0.3 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.17 ETO27940.1 - 4.2e-29 100.7 0.0 1.7e-28 98.7 0.0 2.1 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 ETO27940.1 - 1.9e-09 37.6 0.0 4.3e-08 33.3 0.0 3.0 3 0 0 3 3 3 1 RNA polymerase Rpb1, domain 3 Nitroreductase PF00881.24 ETO27941.1 - 5.3e-29 101.4 0.0 3.7e-28 98.7 0.0 2.0 1 1 0 1 1 1 1 Nitroreductase family TM1586_NiRdase PF14512.6 ETO27941.1 - 3.4e-07 30.1 0.0 0.0061 16.1 0.0 3.0 2 1 1 3 3 3 3 Putative TM nitroreductase PMBR PF09373.10 ETO27941.1 - 0.018 15.2 0.1 0.057 13.6 0.1 1.9 2 0 0 2 2 2 0 Pseudomurein-binding repeat WD40 PF00400.32 ETO27942.1 - 1.1e-16 60.8 1.9 1.6e-06 28.7 0.1 4.5 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27942.1 - 0.00011 22.4 0.1 1.2 9.5 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO27942.1 - 0.016 13.9 0.0 6.1 5.4 0.0 2.8 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Phage_Gp23 PF10669.9 ETO27944.1 - 0.053 13.9 1.6 0.06 13.7 1.6 1.2 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) GFA PF04828.14 ETO27945.1 - 1.4e-08 35.0 1.5 1.4e-08 35.0 1.5 1.5 2 0 0 2 2 2 1 Glutathione-dependent formaldehyde-activating enzyme zf-C3HC4_2 PF13923.6 ETO27945.1 - 0.048 13.5 0.1 0.048 13.5 0.1 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SlyX PF04102.12 ETO27946.1 - 0.012 16.2 4.9 0.084 13.5 0.5 2.6 3 0 0 3 3 3 0 SlyX DUF2716 PF10898.8 ETO27946.1 - 0.072 13.5 1.0 0.27 11.6 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF2716) FANCD2OS PF15124.6 ETO27946.1 - 0.28 11.4 4.5 0.12 12.6 0.9 1.9 1 1 1 2 2 2 0 FANCD2 opposite strand protein YnfE PF17452.2 ETO27946.1 - 0.5 10.7 2.8 4.1 7.8 0.1 2.5 3 0 0 3 3 3 0 Uncharacterized YnfE-like Uds1 PF15456.6 ETO27946.1 - 3.8 7.7 11.8 0.33 11.1 6.2 1.8 1 1 1 2 2 2 0 Up-regulated During Septation CobT PF06213.12 ETO27947.1 - 0.0042 16.5 0.2 0.0049 16.3 0.2 1.2 1 0 0 1 1 1 1 Cobalamin biosynthesis protein CobT TSNAXIP1_N PF15739.5 ETO27947.1 - 0.01 16.2 5.0 0.01 16.2 5.0 1.8 1 1 0 1 1 1 0 Translin-associated factor X-interacting N-terminus CUT PF02376.15 ETO27947.1 - 0.047 13.9 1.1 0.1 12.8 1.1 1.7 1 1 0 1 1 1 0 CUT domain Apolipoprotein PF01442.18 ETO27947.1 - 0.063 13.1 5.4 0.15 11.9 5.4 1.6 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain RRF PF01765.19 ETO27947.1 - 0.069 13.1 6.8 0.091 12.7 6.8 1.2 1 0 0 1 1 1 0 Ribosome recycling factor OrfB_IS605 PF01385.19 ETO27947.1 - 0.087 13.0 3.2 0.17 12.1 1.6 1.9 1 1 1 2 2 2 0 Probable transposase DUF874 PF05917.11 ETO27947.1 - 0.3 10.1 11.5 0.32 10.0 11.5 1.1 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Med11 PF10280.9 ETO27947.1 - 0.46 10.9 6.1 3.6 8.1 6.1 2.0 1 1 0 1 1 1 0 Mediator complex protein YtxH PF12732.7 ETO27947.1 - 1.5 9.4 4.7 15 6.2 4.7 2.3 1 1 0 1 1 1 0 YtxH-like protein Exonuc_VII_L PF02601.15 ETO27947.1 - 4.1 6.9 8.9 4.2 6.8 8.9 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit JAB PF01398.21 ETO27948.1 - 0.0017 18.3 0.2 0.0032 17.4 0.2 1.4 1 0 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease Med9 PF07544.13 ETO27949.1 - 0.014 15.4 1.2 0.014 15.4 1.2 2.5 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 YebO PF13974.6 ETO27949.1 - 6.8 6.8 10.8 1.5 9.0 0.8 3.2 3 0 0 3 3 3 0 YebO-like protein F-box PF00646.33 ETO27952.1 - 0.0012 18.7 0.1 0.0031 17.3 0.0 1.7 2 0 0 2 2 2 1 F-box domain COX15-CtaA PF02628.15 ETO27953.1 - 7.9e-53 179.6 0.0 9.8e-53 179.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome oxidase assembly protein OST3_OST6 PF04756.13 ETO27954.1 - 9.4e-25 87.6 0.7 1.3e-24 87.1 0.7 1.3 1 1 0 1 1 1 1 OST3 / OST6 family, transporter family IFNGR1 PF07140.11 ETO27954.1 - 0.034 14.3 0.0 0.047 13.8 0.0 1.3 1 0 0 1 1 1 0 Interferon gamma receptor (IFNGR1) DUF4229 PF14012.6 ETO27954.1 - 0.048 13.8 0.4 0.21 11.7 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF4229) ISK_Channel PF02060.15 ETO27954.1 - 0.67 9.7 4.4 0.27 11.0 0.3 2.0 2 0 0 2 2 2 0 Slow voltage-gated potassium channel GFD1 PF17331.2 ETO27954.1 - 1.6 9.1 4.9 2.8 8.3 4.9 1.3 1 0 0 1 1 1 0 GFD1 mRNA transport factor Na_Ca_ex PF01699.24 ETO27957.1 - 3.1e-25 88.9 32.0 8.5e-21 74.5 17.4 2.5 2 1 0 2 2 2 2 Sodium/calcium exchanger protein ArfGap PF01412.18 ETO27958.1 - 1.5e-05 25.0 0.5 5.4e-05 23.3 0.5 1.9 1 0 0 1 1 1 1 Putative GTPase activating protein for Arf CW_binding_1 PF01473.20 ETO27958.1 - 0.46 10.9 4.0 0.96 9.9 0.7 2.9 2 0 0 2 2 2 0 Putative cell wall binding repeat Arm PF00514.23 ETO27959.1 - 2.4e-11 43.3 0.6 1.6e-05 24.8 0.0 4.4 5 0 0 5 5 5 2 Armadillo/beta-catenin-like repeat HEAT PF02985.22 ETO27959.1 - 3.5e-11 42.3 0.6 1.6e-05 24.7 0.1 4.1 4 0 0 4 4 4 2 HEAT repeat HEAT_2 PF13646.6 ETO27959.1 - 2.1e-06 28.0 0.0 1.9e-05 25.0 0.0 2.3 3 0 0 3 3 3 1 HEAT repeats HEAT_EZ PF13513.6 ETO27959.1 - 2.6e-06 27.8 0.0 0.00094 19.6 0.0 3.1 2 1 1 3 3 3 2 HEAT-like repeat RICTOR_N PF14664.6 ETO27959.1 - 0.0011 18.1 0.2 0.02 13.9 0.0 2.2 1 1 0 2 2 2 1 Rapamycin-insensitive companion of mTOR, N-term Cnd1 PF12717.7 ETO27959.1 - 0.0013 18.8 0.2 0.011 15.8 0.0 2.4 1 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 DUF3361 PF11841.8 ETO27959.1 - 0.0095 15.9 2.7 0.0096 15.9 0.8 2.0 2 1 0 2 2 2 1 Domain of unknown function (DUF3361) Vac14_Fab1_bd PF12755.7 ETO27959.1 - 0.018 15.6 3.2 0.03 14.9 0.0 2.9 3 1 0 3 3 3 0 Vacuolar 14 Fab1-binding region U-box PF04564.15 ETO27961.1 - 3.2e-10 40.0 0.1 1.4e-09 38.0 0.1 2.2 1 1 0 1 1 1 1 U-box domain DUF4407 PF14362.6 ETO27961.1 - 0.00026 20.4 3.2 0.00026 20.4 3.2 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4407) DUF4446 PF14584.6 ETO27961.1 - 0.086 12.8 4.3 0.35 10.9 4.3 2.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) FlgN PF05130.12 ETO27961.1 - 2.6 8.5 16.0 0.35 11.4 10.4 2.2 2 0 0 2 2 2 0 FlgN protein DUF745 PF05335.13 ETO27961.1 - 3.3 7.4 10.9 0.78 9.4 7.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF745) DUF3450 PF11932.8 ETO27961.1 - 3.8 6.8 18.7 10 5.3 17.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Zip PF02535.22 ETO27961.1 - 3.8 6.6 7.3 0.63 9.2 0.7 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter ImpA_N PF06812.12 ETO27962.1 - 0.044 13.9 0.1 0.12 12.5 0.1 1.7 1 1 0 1 1 1 0 ImpA, N-terminal, type VI secretion system SET PF00856.28 ETO27963.1 - 0.022 15.1 0.0 0.025 14.9 0.0 1.2 1 0 0 1 1 1 0 SET domain zf-C4_ClpX PF06689.13 ETO27963.1 - 0.12 12.2 0.3 0.32 10.9 0.3 1.7 1 0 0 1 1 1 0 ClpX C4-type zinc finger Phasin PF05597.11 ETO27965.1 - 0.034 14.1 1.8 0.039 14.0 1.6 1.3 1 1 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) adh_short PF00106.25 ETO27966.1 - 7.3e-20 71.2 0.0 9.6e-20 70.9 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO27966.1 - 2.9e-12 46.6 0.0 3.9e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO27966.1 - 2.2e-06 27.7 0.0 3.2e-06 27.2 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETO27966.1 - 0.00024 21.1 0.0 0.00032 20.7 0.0 1.1 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETO27966.1 - 0.0063 16.0 0.0 0.008 15.7 0.0 1.1 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DUF1959 PF09218.10 ETO27966.1 - 0.028 14.5 0.1 0.051 13.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1959) Rad10 PF03834.14 ETO27966.1 - 0.068 13.2 0.6 0.14 12.2 0.1 1.8 1 1 1 2 2 2 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) NmrA PF05368.13 ETO27966.1 - 0.087 12.4 0.0 0.12 11.9 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family AAA PF00004.29 ETO27967.1 - 7.6e-16 58.7 0.4 3.6e-15 56.6 0.1 2.0 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO27967.1 - 1.4e-13 50.4 0.2 2.1e-13 49.8 0.2 1.3 1 0 0 1 1 1 1 AAA+ lid domain DUF4870 PF09685.10 ETO27968.1 - 0.026 14.6 0.8 0.026 14.6 0.8 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4870) DUF2721 PF11026.8 ETO27968.1 - 0.069 13.0 0.0 0.069 13.0 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2721) BROMI PF14961.6 ETO27969.1 - 0.22 8.9 2.7 0.22 8.9 2.7 1.0 1 0 0 1 1 1 0 Broad-minded protein PRELI PF04707.14 ETO27970.1 - 9.9e-35 119.7 0.0 1.3e-34 119.3 0.0 1.1 1 0 0 1 1 1 1 PRELI-like family RRM_1 PF00076.22 ETO27971.1 - 0.0014 18.4 0.2 0.0053 16.6 0.2 2.0 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4780 PF16012.5 ETO27971.1 - 0.022 14.2 0.0 0.038 13.5 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4780) CHAT PF12770.7 ETO27972.1 - 1.5e-09 37.7 0.0 2.4e-09 37.1 0.0 1.3 1 0 0 1 1 1 1 CHAT domain PRIMA1 PF16101.5 ETO27972.1 - 4.1 7.5 10.0 10 6.2 10.0 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 RICTOR_V PF14668.6 ETO27973.1 - 0.016 15.4 0.1 0.096 12.9 0.0 2.2 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 RRM_1 PF00076.22 ETO27974.1 - 8.9e-13 47.9 0.4 5.6e-10 38.9 0.1 4.3 3 1 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO27974.1 - 0.00077 19.5 0.0 0.0083 16.2 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif Spo7_2_N PF15407.6 ETO27974.1 - 0.0053 16.4 0.0 0.38 10.4 0.0 3.3 2 0 0 2 2 2 1 Sporulation protein family 7 ParE_toxin PF05016.15 ETO27974.1 - 0.28 11.8 1.6 32 5.2 0.1 2.8 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE DUF2076 PF09849.9 ETO27974.1 - 2.6 8.0 9.6 5.2 7.0 9.6 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Prot_ATP_ID_OB PF16450.5 ETO27975.1 - 1.4e-07 31.4 0.0 2.2e-07 30.7 0.0 1.3 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_13 PF13166.6 ETO27975.1 - 0.0036 16.0 0.2 0.0036 16.0 0.2 1.5 2 0 0 2 2 2 1 AAA domain DegS PF05384.11 ETO27975.1 - 0.0048 16.4 1.1 0.0077 15.7 1.1 1.2 1 0 0 1 1 1 1 Sensor protein DegS AAA PF00004.29 ETO27975.1 - 0.0093 16.4 0.3 0.022 15.2 0.3 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) ADIP PF11559.8 ETO27975.1 - 0.0094 16.0 1.7 0.014 15.5 1.7 1.2 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding AAA_16 PF13191.6 ETO27975.1 - 0.015 15.7 0.0 0.04 14.3 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain DUF3510 PF12022.8 ETO27975.1 - 0.038 14.4 0.2 0.063 13.7 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3510) APG6_N PF17675.1 ETO27975.1 - 0.04 14.4 1.2 0.068 13.7 1.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region PTRF_SDPR PF15237.6 ETO27975.1 - 0.051 13.2 2.3 0.091 12.4 0.9 1.8 2 0 0 2 2 2 0 PTRF/SDPR family SlyX PF04102.12 ETO27975.1 - 0.093 13.4 1.1 0.16 12.6 0.7 1.5 2 0 0 2 2 1 0 SlyX DUF1664 PF07889.12 ETO27975.1 - 0.098 12.7 1.1 0.25 11.4 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Prominin PF05478.11 ETO27975.1 - 0.14 10.1 0.0 0.15 10.0 0.0 1.2 1 0 0 1 1 1 0 Prominin AAA_24 PF13479.6 ETO27975.1 - 0.14 11.8 0.1 0.27 10.9 0.1 1.4 1 0 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ETO27975.1 - 0.17 11.6 0.6 0.96 9.2 0.0 2.0 2 0 0 2 2 2 0 AAA domain Spc7 PF08317.11 ETO27976.1 - 0.00034 19.6 4.2 0.00036 19.5 4.2 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein Filament PF00038.21 ETO27976.1 - 0.0024 17.5 4.2 0.0031 17.1 4.2 1.1 1 0 0 1 1 1 1 Intermediate filament protein ATG16 PF08614.11 ETO27976.1 - 0.0033 17.7 7.5 0.0041 17.4 7.5 1.1 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) Spc24 PF08286.11 ETO27976.1 - 0.0075 16.5 1.3 0.012 15.9 1.3 1.4 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 NleF_casp_inhib PF16809.5 ETO27976.1 - 0.019 14.9 2.9 0.028 14.3 2.9 1.3 1 1 0 1 1 1 0 NleF caspase inhibitor FlaC_arch PF05377.11 ETO27976.1 - 0.068 13.6 0.7 0.45 10.9 0.7 2.1 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) PHTB1_C PF14728.6 ETO27976.1 - 0.11 11.5 6.0 0.14 11.2 6.0 1.1 1 0 0 1 1 1 0 PTHB1 C-terminus DUF948 PF06103.11 ETO27977.1 - 0.14 12.4 0.1 0.14 12.4 0.1 4.2 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 ETO27977.1 - 0.2 12.3 43.1 0.22 12.2 6.0 5.0 3 1 2 5 5 5 0 SlyX Amino_oxidase PF01593.24 ETO27977.1 - 0.21 10.9 5.6 0.1 11.8 3.2 1.5 1 1 0 1 1 1 0 Flavin containing amine oxidoreductase Baculo_PEP_C PF04513.12 ETO27977.1 - 0.25 11.4 23.9 0.19 11.8 4.8 3.6 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus TFIIA PF03153.13 ETO27977.1 - 0.36 10.8 20.3 0.46 10.4 20.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit FAM184 PF15665.5 ETO27977.1 - 1.7 8.4 49.6 1.7 8.4 30.7 2.9 2 1 1 3 3 3 0 Family with sequence similarity 184, A and B DUF1643 PF07799.12 ETO27977.1 - 3.3 7.9 7.3 0.95 9.6 3.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1643) Ribosomal_S6 PF01250.17 ETO27978.1 - 2e-13 50.4 0.0 3.4e-13 49.7 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein S6 DUF179 PF02622.15 ETO27981.1 - 1.4e-05 25.1 0.0 2.8e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Uncharacterized ACR, COG1678 Sigma70_ner PF04546.13 ETO27981.1 - 0.00056 19.9 0.7 0.00084 19.3 0.7 1.3 1 0 0 1 1 1 1 Sigma-70, non-essential region Mpp10 PF04006.12 ETO27981.1 - 0.00072 18.1 11.8 0.00096 17.7 11.8 1.3 1 0 0 1 1 1 1 Mpp10 protein DAG_kinase_N PF14513.6 ETO27981.1 - 0.0012 19.1 5.6 0.0026 18.0 5.6 1.6 1 0 0 1 1 1 1 Diacylglycerol kinase N-terminus NOA36 PF06524.12 ETO27981.1 - 0.0047 16.3 9.4 0.0047 16.3 9.4 1.7 2 0 0 2 2 2 1 NOA36 protein CDC45 PF02724.14 ETO27981.1 - 0.0066 14.8 13.2 0.009 14.4 13.2 1.1 1 0 0 1 1 1 1 CDC45-like protein YL1 PF05764.13 ETO27981.1 - 0.015 15.5 11.1 0.025 14.7 11.1 1.3 1 0 0 1 1 1 0 YL1 nuclear protein Dsh_C PF12316.8 ETO27981.1 - 0.025 15.0 6.8 0.045 14.2 6.8 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CDC27 PF09507.10 ETO27981.1 - 0.033 13.6 13.4 0.047 13.1 13.4 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ETO27981.1 - 0.042 12.1 14.0 0.055 11.7 14.0 1.1 1 0 0 1 1 1 0 Nop14-like family Nop53 PF07767.11 ETO27981.1 - 0.074 12.4 13.1 0.11 11.9 13.1 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Pox_RNA_Pol_19 PF05320.12 ETO27981.1 - 0.44 10.5 9.1 0.82 9.6 9.1 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit SDA1 PF05285.12 ETO27981.1 - 0.74 9.2 16.5 1.1 8.6 16.5 1.2 1 0 0 1 1 1 0 SDA1 Spt5_N PF11942.8 ETO27981.1 - 0.76 10.8 11.7 1.5 9.9 11.7 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal RSB_motif PF16294.5 ETO27981.1 - 0.77 10.1 14.6 35 4.8 0.0 2.4 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif PRP1_N PF06424.12 ETO27981.1 - 0.79 10.1 13.4 1.6 9.1 13.4 1.4 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal FAM176 PF14851.6 ETO27981.1 - 3 7.5 12.1 1.1 8.9 9.5 1.6 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 ETO27981.1 - 4.4 7.7 16.2 9.8 6.6 15.7 1.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Presenilin PF01080.17 ETO27981.1 - 5 5.8 11.8 7.4 5.2 11.8 1.2 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 ETO27981.1 - 8.1 6.7 12.4 13 6.0 12.4 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Ribosomal_L22 PF00237.19 ETO27982.1 - 3.9e-21 75.2 0.1 6.5e-21 74.5 0.1 1.4 1 0 0 1 1 1 1 Ribosomal protein L22p/L17e Ist1 PF03398.14 ETO27983.1 - 2.8e-29 102.1 7.4 1.9e-19 70.2 4.2 3.1 2 1 1 3 3 3 3 Regulator of Vps4 activity in the MVB pathway CRA PF06589.11 ETO27983.1 - 0.47 10.6 9.1 0.093 12.8 2.3 2.3 2 1 0 2 2 2 0 Circumsporozoite-related antigen (CRA) PDZ_6 PF17820.1 ETO27984.1 - 0.012 15.4 0.0 0.022 14.6 0.0 1.4 1 0 0 1 1 1 0 PDZ domain ABC1 PF03109.16 ETO27985.1 - 4.8e-19 68.7 0.0 4.3e-08 33.3 0.0 2.5 2 0 0 2 2 2 2 ABC1 family APH PF01636.23 ETO27985.1 - 0.063 13.2 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family PBP1_TM PF14812.6 ETO27985.1 - 1.3 9.4 5.6 0.29 11.5 0.9 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WD40 PF00400.32 ETO27986.1 - 2.6e-54 180.0 16.4 8.7e-11 42.2 0.0 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO27986.1 - 7.7e-26 90.2 0.7 0.00015 22.0 0.0 6.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO27986.1 - 2.5e-12 46.7 0.1 4.6e-06 26.2 0.0 4.0 2 2 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO27986.1 - 2.7e-12 46.3 2.6 0.12 11.4 0.0 6.2 1 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO27986.1 - 2.1e-11 44.0 0.0 0.00034 20.5 0.0 3.6 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO27986.1 - 1.5e-07 30.4 0.4 0.35 9.5 0.0 4.5 2 1 3 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO27986.1 - 7.8e-05 21.4 1.1 0.15 10.5 0.1 3.4 1 1 2 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO27986.1 - 0.00093 19.1 4.7 14 5.8 0.0 5.3 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Utp8 PF10395.9 ETO27986.1 - 0.044 12.3 0.2 1.1 7.7 0.0 2.7 2 1 1 3 3 3 0 Utp8 family Frtz PF11768.8 ETO27986.1 - 0.082 11.2 0.0 1.3 7.2 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Nucleoporin_N PF08801.11 ETO27986.1 - 0.089 11.5 3.1 0.56 8.9 2.5 2.8 1 1 1 2 2 2 0 Nup133 N terminal like TruB-C_2 PF09157.11 ETO27986.1 - 0.11 12.6 0.0 0.69 10.0 0.0 2.3 2 0 0 2 2 2 0 Pseudouridine synthase II TruB, C-terminal RRM_1 PF00076.22 ETO27989.1 - 8.2e-45 150.5 0.1 7.6e-20 70.5 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PABP PF00658.18 ETO27989.1 - 1.3e-26 92.5 1.3 3.4e-26 91.2 1.3 1.8 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Nup35_RRM_2 PF14605.6 ETO27989.1 - 0.021 14.8 0.0 5.3 7.1 0.0 2.4 2 0 0 2 2 2 0 Nup53/35/40-type RNA recognition motif BRAP2 PF07576.12 ETO27989.1 - 0.077 13.2 0.0 0.16 12.2 0.0 1.4 1 0 0 1 1 1 0 BRCA1-associated protein 2 FAM176 PF14851.6 ETO27990.1 - 0.08 12.6 7.8 3.8 7.2 4.4 2.4 2 0 0 2 2 2 0 FAM176 family BUD22 PF09073.10 ETO27990.1 - 0.12 11.7 14.8 0.15 11.4 14.8 1.1 1 0 0 1 1 1 0 BUD22 SMN PF06003.12 ETO27990.1 - 0.12 11.6 9.9 0.32 10.2 9.9 1.7 1 1 0 1 1 1 0 Survival motor neuron protein (SMN) Gemini_mov PF01708.16 ETO27990.1 - 0.16 11.8 0.0 0.35 10.6 0.0 1.6 1 1 0 1 1 1 0 Geminivirus putative movement protein Nop14 PF04147.12 ETO27990.1 - 0.82 7.8 18.9 1 7.5 18.9 1.1 1 0 0 1 1 1 0 Nop14-like family XAP5 PF04921.14 ETO27990.1 - 0.98 9.2 10.0 4 7.2 1.0 2.1 2 0 0 2 2 2 0 XAP5, circadian clock regulator DUF4637 PF15470.6 ETO27990.1 - 5.4 6.7 11.4 0.58 9.9 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) PPP4R2 PF09184.11 ETO27990.1 - 7.4 6.1 17.3 10 5.6 17.3 1.2 1 0 0 1 1 1 0 PPP4R2 Senescence_reg PF04520.13 ETO27991.1 - 0.036 14.9 2.6 0.036 14.9 2.6 1.9 2 0 0 2 2 2 0 Senescence regulator FYVE PF01363.21 ETO27991.1 - 5.7 7.2 9.3 91 3.3 9.3 2.6 1 1 0 1 1 1 0 FYVE zinc finger Imm41 PF15592.6 ETO27992.1 - 0.028 14.8 0.0 0.046 14.1 0.0 1.3 1 0 0 1 1 1 0 Immunity protein 41 IPP-2 PF04979.14 ETO27993.1 - 7.9e-06 26.6 0.5 7.9e-06 26.6 0.5 2.1 2 0 0 2 2 2 1 Protein phosphatase inhibitor 2 (IPP-2) ABC_membrane_2 PF06472.15 ETO27994.1 - 7.9e-10 38.6 4.3 1.1e-09 38.2 4.3 1.1 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 Spore_III_AF PF09581.10 ETO27995.1 - 0.066 13.2 0.2 0.12 12.3 0.2 1.4 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) V_ATPase_I PF01496.19 ETO27995.1 - 0.88 7.4 6.0 0.052 11.5 0.1 1.9 3 0 0 3 3 3 0 V-type ATPase 116kDa subunit family Ctr PF04145.15 ETO27995.1 - 1.8 9.2 9.9 0.27 11.9 1.6 2.8 3 1 0 3 3 3 0 Ctr copper transporter family XRN_M PF17846.1 ETO27996.1 - 1.8e-56 192.0 1.4 1.8e-56 192.0 1.4 2.1 2 0 0 2 2 2 1 Xrn1 helical domain XRN1_D1 PF18332.1 ETO27996.1 - 9.3e-13 48.4 0.1 2.2e-12 47.2 0.1 1.5 1 0 0 1 1 1 1 Exoribonuclease Xrn1 D1 domain TIP41 PF04176.13 ETO27996.1 - 0.065 12.7 0.1 0.23 10.9 0.1 1.9 1 0 0 1 1 1 0 TIP41-like family Herpes_DNAp_acc PF04929.12 ETO27996.1 - 3 6.7 7.1 4.9 6.0 7.1 1.2 1 0 0 1 1 1 0 Herpes DNA replication accessory factor PIEZO PF15917.5 ETO27997.1 - 0.012 15.1 0.1 0.015 14.8 0.1 1.1 1 0 0 1 1 1 0 Piezo DUF4515 PF14988.6 ETO27997.1 - 0.021 14.7 3.5 0.029 14.2 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4515) CE2_N PF17996.1 ETO27997.1 - 0.027 14.4 0.2 0.039 13.9 0.2 1.1 1 0 0 1 1 1 0 Carbohydrate esterase 2 N-terminal MoeA_N PF03453.17 ETO27997.1 - 0.049 13.4 0.3 0.064 13.0 0.3 1.2 1 0 0 1 1 1 0 MoeA N-terminal region (domain I and II) CP12 PF02672.15 ETO27997.1 - 0.074 13.8 1.0 0.13 13.1 0.6 1.5 1 1 0 1 1 1 0 CP12 domain Peptidase_M3 PF01432.20 ETO27998.1 - 1.4e-120 403.6 2.3 2.7e-104 350.0 0.1 2.4 2 0 0 2 2 2 2 Peptidase family M3 VPS11_C PF12451.8 ETO27998.1 - 0.13 12.6 0.3 5.2 7.4 0.0 2.8 2 0 0 2 2 2 0 Vacuolar protein sorting protein 11 C terminal DUF1284 PF06935.11 ETO27998.1 - 0.27 11.7 1.8 1.5 9.3 0.1 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1284) Neur_chan_memb PF02932.16 ETO27999.1 - 0.015 15.3 0.0 0.032 14.3 0.0 1.5 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sensor PF13796.6 ETO27999.1 - 0.1 12.6 1.0 0.52 10.3 0.0 2.3 2 1 1 3 3 3 0 Putative sensor ATP-synt_8 PF00895.20 ETO27999.1 - 0.3 11.6 0.1 0.3 11.6 0.1 3.3 2 0 0 2 2 2 0 ATP synthase protein 8 UbiA PF01040.18 ETO27999.1 - 0.42 9.9 7.9 0.5 9.6 6.2 1.7 1 1 1 2 2 2 0 UbiA prenyltransferase family BCDHK_Adom3 PF10436.9 ETO28000.1 - 0.092 12.6 0.0 0.24 11.2 0.0 1.7 1 1 0 1 1 1 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Herpes_IE1 PF07340.11 ETO28000.1 - 0.2 10.6 1.2 3.3 6.5 0.0 2.2 1 1 1 2 2 2 0 Cytomegalovirus IE1 protein T3SS_TC PF06511.11 ETO28000.1 - 0.24 10.7 1.6 0.4 10.0 1.6 1.3 1 0 0 1 1 1 0 Type III secretion systems tip complex components Pkinase PF00069.25 ETO28001.1 - 3e-73 246.5 0.1 3.9e-73 246.0 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28001.1 - 8.4e-44 149.8 0.1 8.2e-31 107.2 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO28001.1 - 1.2e-05 24.8 0.2 0.00065 19.1 0.0 3.2 2 2 1 3 3 3 1 Kinase-like Pkinase_fungal PF17667.1 ETO28001.1 - 0.00042 19.2 0.0 0.015 14.1 0.0 2.1 1 1 1 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ETO28001.1 - 0.013 15.0 0.0 0.024 14.1 0.0 1.5 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.14 ETO28001.1 - 0.038 13.3 1.0 0.06 12.7 1.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ETO28001.1 - 0.047 12.7 0.0 0.076 12.1 0.0 1.2 1 0 0 1 1 1 0 Seadornavirus VP7 APH PF01636.23 ETO28001.1 - 0.11 12.4 2.8 0.24 11.3 0.6 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Secretin_N_2 PF07655.13 ETO28002.1 - 6.6 7.3 17.8 0.32 11.5 11.9 1.9 2 0 0 2 2 2 0 Secretin N-terminal domain DEAD PF00270.29 ETO28004.1 - 2.5e-22 79.5 3.1 3.1e-20 72.7 1.0 3.0 2 1 0 2 2 2 2 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO28004.1 - 2.7e-22 79.2 2.6 2.3e-20 73.0 0.3 2.5 2 0 0 2 2 2 2 Helicase conserved C-terminal domain ResIII PF04851.15 ETO28004.1 - 1.9e-13 50.8 0.3 9.1e-12 45.3 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit SWI2_SNF2 PF18766.1 ETO28004.1 - 4e-05 23.4 0.7 0.00017 21.3 0.1 2.1 1 1 1 2 2 2 1 SWI2/SNF2 ATPase AAA_19 PF13245.6 ETO28004.1 - 0.021 15.1 0.5 0.11 12.9 0.5 2.1 1 1 0 1 1 1 0 AAA domain Helicase_C_2 PF13307.6 ETO28004.1 - 0.12 12.6 0.0 0.42 10.8 0.0 1.9 2 0 0 2 2 2 0 Helicase C-terminal domain DUF5578 PF17741.1 ETO28005.1 - 0.0043 16.5 0.2 0.029 13.8 0.0 2.2 2 0 0 2 2 2 1 Family of unknown function (DUF5578) IPP-2 PF04979.14 ETO28005.1 - 1.2 9.9 4.9 0.52 11.1 2.3 1.7 2 0 0 2 2 2 0 Protein phosphatase inhibitor 2 (IPP-2) Arm PF00514.23 ETO28005.1 - 1.4 9.0 12.2 12 6.1 0.1 4.7 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat APT PF03440.14 ETO28006.1 - 0.024 14.6 0.0 0.44 10.5 0.0 2.2 1 1 1 2 2 2 0 Aerolysin/Pertussis toxin (APT) domain zinc_ribbon_15 PF17032.5 ETO28006.1 - 0.075 13.8 4.0 0.38 11.5 2.3 2.4 1 1 1 2 2 2 0 zinc-ribbon family ILEI PF15711.5 ETO28007.1 - 4.1e-05 24.0 0.0 0.039 14.4 0.0 2.5 2 0 0 2 2 2 2 Interleukin-like EMT inducer SUIM_assoc PF16619.5 ETO28007.1 - 0.0019 18.2 7.4 0.0079 16.2 7.4 2.2 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 DUF5308 PF17233.2 ETO28007.1 - 4.1 7.6 5.6 8.2 6.6 1.8 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5308) GPCR_chapero_1 PF11904.8 ETO28008.1 - 9.1e-18 64.7 0.1 9.1e-18 64.7 0.1 2.8 2 1 0 2 2 2 1 GPCR-chaperone Ank_3 PF13606.6 ETO28008.1 - 2.9e-05 24.1 0.0 0.00012 22.3 0.0 2.1 1 0 0 1 1 1 1 Ankyrin repeat Ank_2 PF12796.7 ETO28008.1 - 9.8e-05 22.9 0.0 0.00089 19.8 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO28008.1 - 0.00051 20.3 0.0 0.0011 19.2 0.0 1.6 1 0 0 1 1 1 1 Ankyrin repeats (many copies) UBA PF00627.31 ETO28008.1 - 0.00059 19.7 0.1 0.0015 18.4 0.1 1.7 1 0 0 1 1 1 1 UBA/TS-N domain Ank PF00023.30 ETO28008.1 - 0.00081 19.7 0.0 0.002 18.5 0.0 1.7 1 0 0 1 1 1 1 Ankyrin repeat Presenilin PF01080.17 ETO28008.1 - 0.019 13.8 1.3 0.03 13.1 1.3 1.3 1 0 0 1 1 1 0 Presenilin Ank_4 PF13637.6 ETO28008.1 - 0.037 14.6 0.0 0.13 12.9 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) U3_assoc_6 PF08640.11 ETO28008.1 - 0.56 10.3 3.3 2.4 8.3 0.0 2.9 3 0 0 3 3 3 0 U3 small nucleolar RNA-associated protein 6 NOA36 PF06524.12 ETO28012.1 - 0.0061 15.9 10.3 0.0061 15.9 10.3 2.2 2 0 0 2 2 2 1 NOA36 protein Sporozoite_P67 PF05642.11 ETO28012.1 - 0.15 10.1 3.9 0.25 9.4 3.9 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2489 PF10675.9 ETO28012.1 - 0.37 10.7 0.0 0.37 10.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2489) RNA_pol_Rpb4 PF03874.16 ETO28013.1 - 2.2e-08 34.4 0.4 6.6e-08 32.9 0.1 2.0 1 1 0 1 1 1 1 RNA polymerase Rpb4 Tmemb_cc2 PF10267.9 ETO28014.1 - 0.00047 19.4 10.8 0.00072 18.8 10.8 1.2 1 0 0 1 1 1 1 Predicted transmembrane and coiled-coil 2 protein SAM_2 PF07647.17 ETO28014.1 - 0.012 15.7 0.1 0.066 13.3 0.0 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) HIGH_NTase1 PF05636.11 ETO28014.1 - 0.59 9.3 11.8 1.2 8.3 9.2 2.3 2 1 1 3 3 3 0 HIGH Nucleotidyl Transferase PARG_cat PF05028.14 ETO28015.1 - 9.9e-17 61.2 0.6 1.4e-16 60.8 0.6 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PARG_cat PF05028.14 ETO28016.1 - 4.4e-56 190.6 1.3 5.4e-56 190.3 1.3 1.1 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) DUF2263 PF10021.9 ETO28016.1 - 0.13 12.6 0.0 0.29 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2263) Peptidase_U4 PF03419.13 ETO28017.1 - 0.016 14.5 0.1 0.029 13.7 0.1 1.4 1 0 0 1 1 1 0 Sporulation factor SpoIIGA Mito_carr PF00153.27 ETO28018.1 - 1.2e-13 50.8 1.5 2.2e-07 30.7 0.0 3.3 3 0 0 3 3 3 3 Mitochondrial carrier protein GCHY-1 PF02649.14 ETO28019.1 - 0.058 12.9 0.0 0.19 11.2 0.0 1.7 1 1 1 2 2 2 0 Type I GTP cyclohydrolase folE2 PRP38_assoc PF12871.7 ETO28020.1 - 0.017 15.7 59.9 0.017 15.7 59.9 3.2 1 1 2 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term LAP1C PF05609.12 ETO28020.1 - 0.15 11.2 21.0 0.25 10.4 21.0 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Orf78 PF06024.12 ETO28020.1 - 6.9 7.0 0.0 6.9 7.0 0.0 4.5 2 1 1 3 3 3 0 Orf78 (ac78) TPR_1 PF00515.28 ETO28021.1 - 1.9e-06 27.4 0.6 0.084 12.7 0.1 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28021.1 - 7.7e-06 25.6 0.9 0.11 12.7 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28021.1 - 1.8e-05 24.5 0.1 0.091 13.0 0.1 3.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28021.1 - 0.00034 20.2 0.9 0.024 14.3 0.3 2.6 1 1 1 2 2 2 2 TPR repeat TPR_12 PF13424.6 ETO28021.1 - 0.0031 17.7 0.5 0.017 15.4 0.6 2.1 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO28021.1 - 0.011 16.2 0.0 0.047 14.2 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO28021.1 - 0.019 15.7 0.0 0.45 11.5 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28021.1 - 0.091 12.8 0.4 12 6.2 0.1 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO28021.1 - 0.098 13.3 0.0 0.17 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO28021.1 - 0.17 12.1 0.0 0.47 10.6 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Lectin_N PF03954.14 ETO28021.1 - 2.2 8.0 8.4 8.9 6.1 8.4 2.1 1 0 0 1 1 1 0 Hepatic lectin, N-terminal domain Thiolase_N PF00108.23 ETO28022.1 - 8.2e-64 215.5 0.1 3.5e-61 206.8 0.1 2.5 2 1 0 2 2 2 1 Thiolase, N-terminal domain Thiolase_C PF02803.18 ETO28022.1 - 6.4e-44 148.6 0.1 1e-43 147.9 0.1 1.3 1 0 0 1 1 1 1 Thiolase, C-terminal domain Kelch_6 PF13964.6 ETO28023.1 - 0.00015 21.9 1.4 0.48 10.8 0.2 4.4 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO28023.1 - 0.00018 21.0 0.1 0.82 9.3 0.0 3.5 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO28023.1 - 0.0051 16.7 1.9 1.4 9.0 0.1 3.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO28023.1 - 0.0087 16.0 0.4 3.7 7.7 0.2 3.5 3 0 0 3 3 3 1 Kelch motif Glyoxal_oxid_N PF07250.11 ETO28023.1 - 0.056 12.6 0.1 3 7.0 0.0 2.7 2 1 0 2 2 2 0 Glyoxal oxidase N-terminus WD40 PF00400.32 ETO28024.1 - 2.7e-68 224.2 16.3 4.2e-11 43.2 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28024.1 - 1.9e-20 72.9 4.2 7.9e-08 32.5 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28024.1 - 2.5e-20 72.7 0.1 0.006 15.6 0.0 5.7 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO28024.1 - 2.1e-08 33.8 1.2 0.13 11.5 0.0 3.6 1 1 4 5 5 5 5 WD40-like domain PD40 PF07676.12 ETO28024.1 - 4.9e-08 32.7 8.5 0.94 9.5 0.0 5.6 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO28024.1 - 2.1e-06 26.7 11.0 0.081 11.5 0.8 5.7 1 1 5 6 6 6 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO28024.1 - 9e-05 21.9 0.9 1.7 7.9 0.0 4.0 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal HARP PF07443.13 ETO28024.1 - 0.00045 19.8 0.6 0.98 9.1 0.0 4.7 6 0 0 6 6 6 1 HepA-related protein (HARP) DUF5570 PF17731.1 ETO28024.1 - 0.00099 19.2 2.8 9 6.4 0.0 4.8 1 1 5 6 6 6 1 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO28024.1 - 0.0023 17.6 4.4 4.6 7.0 0.0 4.7 5 0 0 5 5 5 2 Proteasome subunit A N-terminal signature DUF2527 PF10736.9 ETO28024.1 - 0.0064 16.3 2.1 1.9 8.4 0.2 4.2 4 0 0 4 4 4 1 Protein of unknown function (DUF2627) Nucleoporin_N PF08801.11 ETO28024.1 - 0.0082 14.9 7.4 0.55 8.9 4.9 4.0 1 1 3 4 4 4 1 Nup133 N terminal like BBS2_Mid PF14783.6 ETO28024.1 - 0.0084 16.1 7.3 18 5.4 0.0 5.0 4 1 1 5 5 4 0 Ciliary BBSome complex subunit 2, middle region VID27 PF08553.10 ETO28024.1 - 0.0088 15.1 0.1 1 8.3 0.0 2.4 2 1 0 2 2 2 1 VID27 C-terminal WD40-like domain Mid2 PF04478.12 ETO28024.1 - 0.014 15.3 1.6 4.6 7.1 0.1 3.5 1 1 3 4 4 4 0 Mid2 like cell wall stress sensor Gmad1 PF10647.9 ETO28024.1 - 0.017 14.9 0.0 0.07 12.9 0.0 2.2 1 1 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain Utp8 PF10395.9 ETO28024.1 - 0.16 10.5 0.1 1.2 7.5 0.1 2.1 1 1 1 2 2 2 0 Utp8 family Vac_Fusion PF02346.16 ETO28024.1 - 0.16 11.6 0.2 2 8.1 0.0 2.7 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF1797 PF08796.10 ETO28024.1 - 0.17 12.0 0.0 10 6.3 0.0 3.1 1 1 2 3 3 3 0 Protein of unknown function (DUF1797) Pkinase PF00069.25 ETO28025.1 - 1.2e-30 106.8 0.0 2e-30 106.0 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28025.1 - 2.9e-12 46.4 0.0 4.4e-12 45.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO28025.1 - 0.0035 17.3 0.0 0.0056 16.6 0.0 1.2 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO28025.1 - 0.0044 16.4 0.1 0.0069 15.8 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pox_ser-thr_kin PF05445.11 ETO28025.1 - 0.017 14.1 0.2 0.025 13.6 0.2 1.2 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Kinase-like PF14531.6 ETO28025.1 - 0.037 13.3 0.0 0.086 12.1 0.0 1.5 1 1 0 1 1 1 0 Kinase-like MRAP PF15183.6 ETO28026.1 - 0.018 14.9 0.0 0.057 13.4 0.0 1.9 1 0 0 1 1 1 0 Melanocortin-2 receptor accessory protein family DUF5133 PF17196.4 ETO28026.1 - 0.5 10.6 3.6 0.29 11.4 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF5133) G-alpha PF00503.20 ETO28027.1 - 5.7e-18 65.2 14.3 5.8e-14 52.0 0.4 3.2 2 1 1 3 3 3 3 G-protein alpha subunit Merozoite_SPAM PF07133.11 ETO28028.1 - 0.075 13.0 9.5 0.1 12.6 9.5 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) dNK PF01712.19 ETO28029.1 - 1.2e-09 38.4 1.5 1.8e-08 34.5 1.5 2.0 1 1 0 1 1 1 1 Deoxynucleoside kinase cobW PF02492.19 ETO28029.1 - 0.016 14.8 0.0 0.023 14.3 0.0 1.2 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain Zeta_toxin PF06414.12 ETO28029.1 - 0.076 12.3 0.0 0.11 11.8 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin AAA_18 PF13238.6 ETO28029.1 - 0.12 13.0 0.2 0.17 12.4 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO28029.1 - 0.15 12.4 0.0 0.2 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain AAA_33 PF13671.6 ETO28029.1 - 0.16 12.1 0.0 0.17 12.1 0.0 1.2 1 0 0 1 1 1 0 AAA domain Collagen PF01391.18 ETO28029.1 - 0.21 11.4 0.0 0.31 10.8 0.0 1.2 1 0 0 1 1 1 0 Collagen triple helix repeat (20 copies) dNK PF01712.19 ETO28030.1 - 4.2e-18 66.0 0.5 5e-18 65.7 0.5 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase Thymidylate_kin PF02223.17 ETO28030.1 - 1.3e-05 25.0 0.0 1.8e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 Thymidylate kinase Nucleoporin_FG PF13634.6 ETO28031.1 - 8.8 7.3 41.4 1.6 9.6 17.3 2.7 1 1 1 2 2 2 0 Nucleoporin FG repeat region COX4_pro_2 PF07835.12 ETO28034.1 - 0.069 13.3 1.2 0.069 13.3 1.2 2.0 2 0 0 2 2 2 0 Bacterial aa3 type cytochrome c oxidase subunit IV NIF PF03031.18 ETO28035.1 - 2.7e-14 53.2 0.0 4.5e-14 52.5 0.0 1.3 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase RNaseH_pPIWI_RE PF13032.6 ETO28036.1 - 0.11 12.4 2.0 0.16 11.9 2.0 1.2 1 0 0 1 1 1 0 RNaseH domain of pPIWI_RE Tir_receptor_N PF07490.11 ETO28038.1 - 0.22 11.3 1.2 0.35 10.7 0.5 1.6 1 1 0 1 1 1 0 Translocated intimin receptor (Tir) N-terminus DUF4287 PF14117.6 ETO28038.1 - 0.24 11.6 1.5 1.5 9.0 1.5 2.2 1 1 0 1 1 1 0 Domain of unknown function (DUF4287) HECT PF00632.25 ETO28039.1 - 6.6e-11 42.2 0.0 1e-10 41.6 0.0 1.3 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Laminin_G_3 PF13385.6 ETO28039.1 - 3.4e-10 40.3 0.0 1.5e-09 38.2 0.0 2.1 2 0 0 2 2 2 1 Concanavalin A-like lectin/glucanases superfamily MSP1_C PF07462.11 ETO28041.1 - 0.003 16.3 2.2 0.0054 15.5 2.2 1.4 1 0 0 1 1 1 1 Merozoite surface protein 1 (MSP1) C-terminus Scm3 PF10384.9 ETO28041.1 - 0.15 11.8 0.1 0.39 10.5 0.0 1.6 2 0 0 2 2 2 0 Centromere protein Scm3 SprA-related PF12118.8 ETO28041.1 - 0.99 8.5 16.6 1.4 8.0 16.6 1.2 1 0 0 1 1 1 0 SprA-related family zf-RanBP PF00641.18 ETO28042.1 - 3.9e-08 32.5 16.0 3.1e-06 26.4 1.4 3.1 3 0 0 3 3 3 2 Zn-finger in Ran binding protein and others 7tm_1 PF00001.21 ETO28042.1 - 0.0041 16.5 0.0 0.095 12.0 0.0 2.2 2 0 0 2 2 2 1 7 transmembrane receptor (rhodopsin family) Androgen_recep PF02166.16 ETO28042.1 - 0.015 14.2 0.2 0.03 13.2 0.2 1.4 1 0 0 1 1 1 0 Androgen receptor EphA2_TM PF14575.6 ETO28042.1 - 0.27 12.1 4.8 6 7.8 0.0 3.4 3 1 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain DZR PF12773.7 ETO28042.1 - 0.33 11.0 9.7 0.91 9.6 0.6 2.4 2 0 0 2 2 2 0 Double zinc ribbon RSN1_TM PF13967.6 ETO28042.1 - 0.37 10.5 7.4 2.5 7.8 0.0 2.9 3 0 0 3 3 2 0 Late exocytosis, associated with Golgi transport zf-RING_10 PF16685.5 ETO28042.1 - 0.4 10.9 4.9 1.1 9.4 1.1 2.4 2 0 0 2 2 2 0 zinc RING finger of MSL2 Tnp_zf-ribbon_2 PF13842.6 ETO28042.1 - 0.42 11.5 4.8 15 6.5 0.2 3.0 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon Cadherin_C_2 PF16492.5 ETO28042.1 - 0.6 10.9 5.2 1.1 10.0 0.3 2.9 3 0 0 3 3 3 0 Cadherin cytoplasmic C-terminal DUF1180 PF06679.12 ETO28042.1 - 1.1 9.7 7.9 1.9 8.9 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF1180) DUF4834 PF16118.5 ETO28042.1 - 2.8 9.0 20.1 4.3 8.4 0.0 4.1 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) SID-1_RNA_chan PF13965.6 ETO28042.1 - 5.2 5.4 7.8 24 3.2 4.6 2.5 1 1 1 2 2 2 0 dsRNA-gated channel SID-1 Pap_E4 PF02711.14 ETO28042.1 - 8.1 7.5 13.2 7.8 7.5 0.9 3.8 3 1 0 3 3 3 0 E4 protein Caskin1-CID PF16600.5 ETO28042.1 - 9.3 6.9 7.9 1.6 9.4 1.9 2.5 2 0 0 2 2 2 0 Caskin1 CASK-interaction domain Vps36-NZF-N PF16988.5 ETO28042.1 - 9.6 5.7 21.2 2.2 7.8 0.7 4.0 2 1 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain RasGEF PF00617.19 ETO28043.1 - 6.2e-34 117.7 0.4 1.6e-33 116.4 0.4 1.7 1 0 0 1 1 1 1 RasGEF domain DDHD PF02862.17 ETO28044.1 - 0.46 10.6 7.7 0.11 12.6 1.5 2.2 2 0 0 2 2 2 0 DDHD domain AAA_11 PF13086.6 ETO28044.1 - 2.6 7.8 13.7 0.9 9.3 10.6 1.7 2 0 0 2 2 2 0 AAA domain GAGA_bind PF06217.12 ETO28044.1 - 4.7 7.4 18.1 0.57 10.4 13.6 1.7 2 0 0 2 2 2 0 GAGA binding protein-like family Endomucin PF07010.12 ETO28044.1 - 5.7 6.8 21.6 2.5 8.0 6.8 2.3 2 0 0 2 2 2 0 Endomucin MFS_1 PF07690.16 ETO28045.1 - 6.2e-10 38.5 0.0 1.2e-09 37.6 0.0 1.5 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF2207 PF09972.9 ETO28045.1 - 0.0002 20.3 0.9 0.063 12.0 0.0 2.2 2 0 0 2 2 2 2 Predicted membrane protein (DUF2207) PP-binding PF00550.25 ETO28046.1 - 5.2e-11 42.8 0.4 1e-10 41.8 0.4 1.5 1 0 0 1 1 1 1 Phosphopantetheine attachment site PP-binding_2 PF14573.6 ETO28046.1 - 0.0018 18.4 0.2 0.0027 17.9 0.2 1.3 1 0 0 1 1 1 1 Acyl-carrier Chorion_2 PF03964.15 ETO28046.1 - 0.0071 17.2 0.7 0.011 16.5 0.7 1.2 1 0 0 1 1 1 1 Chorion family 2 SH3_12 PF18129.1 ETO28047.1 - 4.9e-21 74.6 0.4 7.8e-21 74.0 0.4 1.3 1 0 0 1 1 1 1 Xrn1 SH3-like domain Ribosomal_L35Ae PF01247.18 ETO28048.1 - 0.05 13.8 1.5 0.072 13.3 0.0 2.1 2 0 0 2 2 2 0 Ribosomal protein L35Ae UPF0669 PF17065.5 ETO28048.1 - 0.24 11.1 2.6 0.46 10.2 2.6 1.5 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 Spore_coat_CotO PF14153.6 ETO28048.1 - 0.52 10.2 14.7 0.17 11.8 11.9 1.6 2 0 0 2 2 2 0 Spore coat protein CotO NPR3 PF03666.13 ETO28048.1 - 0.71 8.6 17.4 1.1 8.0 17.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO28048.1 - 0.96 8.6 8.5 1.3 8.1 8.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO28048.1 - 7 5.3 16.5 11 4.7 16.5 1.2 1 0 0 1 1 1 0 Presenilin Membralin PF09746.9 ETO28048.1 - 7.8 5.4 11.8 12 4.8 11.8 1.3 1 0 0 1 1 1 0 Tumour-associated protein Atrophin-1 PF03154.15 ETO28048.1 - 8.3 4.5 11.6 11 4.1 11.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family SLC12 PF03522.15 ETO28048.1 - 8.8 5.2 15.5 14 4.5 15.5 1.3 1 0 0 1 1 1 0 Solute carrier family 12 GTP_EFTU PF00009.27 ETO28049.1 - 3.9e-22 78.7 0.1 5.3e-22 78.3 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETO28049.1 - 0.0022 17.5 2.6 0.0054 16.2 1.4 2.2 2 1 0 2 2 2 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO28049.1 - 0.013 15.6 0.0 0.036 14.2 0.0 1.8 1 0 0 1 1 1 0 50S ribosome-binding GTPase GTP_EFTU_D2 PF03144.25 ETO28049.1 - 0.049 14.0 0.1 0.1 13.0 0.1 1.6 1 0 0 1 1 1 0 Elongation factor Tu domain 2 ATP_bind_1 PF03029.17 ETO28049.1 - 0.064 13.0 1.4 0.39 10.5 1.4 2.2 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein DUF4407 PF14362.6 ETO28049.1 - 0.14 11.5 0.2 0.22 10.8 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF5595 PF18077.1 ETO28049.1 - 0.2 11.8 2.1 0.46 10.6 2.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5595) Taq-exonuc PF09281.10 ETO28049.1 - 0.31 11.0 0.7 0.6 10.1 0.1 1.7 2 0 0 2 2 2 0 Taq polymerase, exonuclease Churchill PF06573.11 ETO28050.1 - 0.011 16.0 0.4 0.027 14.8 0.4 1.7 1 0 0 1 1 1 0 Churchill protein EamA PF00892.20 ETO28051.1 - 5.2e-05 23.4 6.4 6.8e-05 23.1 6.4 1.2 1 0 0 1 1 1 1 EamA-like transporter family DUF1361 PF07099.11 ETO28051.1 - 0.092 12.7 3.7 0.39 10.7 0.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1361) TPR_2 PF07719.17 ETO28053.1 - 1.5e-05 24.7 0.0 7.6e-05 22.5 0.0 2.3 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28053.1 - 1.6e-05 24.5 0.0 6.2e-05 22.6 0.0 2.1 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28053.1 - 0.001 19.1 0.0 0.0058 16.7 0.0 2.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28053.1 - 0.0027 18.0 0.0 0.0072 16.6 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28053.1 - 0.0042 17.0 0.0 0.026 14.5 0.0 2.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO28053.1 - 0.011 15.5 0.0 0.047 13.6 0.0 2.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28053.1 - 0.02 14.6 0.1 0.82 9.4 0.0 2.7 1 1 1 2 2 2 0 TPR repeat TLD PF07534.16 ETO28055.1 - 1.9e-14 54.1 4.0 1.9e-14 54.1 4.0 1.8 2 0 0 2 2 2 1 TLD fn3 PF00041.21 ETO28055.1 - 0.015 15.6 0.0 0.059 13.7 0.0 2.1 1 0 0 1 1 1 0 Fibronectin type III domain BUD22 PF09073.10 ETO28055.1 - 0.054 12.8 61.9 0.17 11.2 61.9 1.7 1 1 0 1 1 1 0 BUD22 SgrR_N PF12793.7 ETO28055.1 - 0.1 12.8 0.1 0.1 12.8 0.1 2.1 2 0 0 2 2 2 0 Sugar transport-related sRNA regulator N-term Hid1 PF12722.7 ETO28055.1 - 4.4 5.3 16.6 7.6 4.5 16.6 1.4 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Hydrolase_4 PF12146.8 ETO28056.1 - 1.9e-16 60.1 0.0 3.9e-10 39.4 0.0 2.2 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO28056.1 - 3.3e-13 49.9 0.2 2.2e-06 27.5 0.0 2.8 2 1 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO28056.1 - 6.5e-12 46.5 0.0 8.3e-12 46.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_2 PF02230.16 ETO28056.1 - 4e-08 33.3 0.1 0.0069 16.2 0.2 2.4 2 0 0 2 2 2 2 Phospholipase/Carboxylesterase Ser_hydrolase PF06821.13 ETO28056.1 - 0.014 15.2 0.0 0.077 12.8 0.0 2.0 2 0 0 2 2 2 0 Serine hydrolase Peptidase_S9 PF00326.21 ETO28056.1 - 0.016 14.7 0.0 0.15 11.5 0.1 2.3 2 0 0 2 2 2 0 Prolyl oligopeptidase family FSH1 PF03959.13 ETO28056.1 - 0.023 14.4 0.1 0.11 12.1 0.1 2.0 1 1 0 1 1 1 0 Serine hydrolase (FSH1) Dynein_AAA_lid PF17852.1 ETO28056.1 - 0.028 14.5 0.0 0.078 13.1 0.0 1.9 1 0 0 1 1 1 0 Dynein heavy chain AAA lid domain LIDHydrolase PF10230.9 ETO28056.1 - 0.036 13.6 0.3 0.24 10.9 0.3 2.2 1 1 0 1 1 1 0 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 ETO28056.1 - 0.038 13.8 0.0 0.1 12.5 0.0 1.7 2 0 0 2 2 2 0 Lipase (class 3) Cwf_Cwc_15 PF04889.12 ETO28059.1 - 1.8 8.2 25.4 2.5 7.8 25.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein SURF2 PF05477.11 ETO28059.1 - 4.5 6.9 17.2 6.1 6.5 17.2 1.1 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) TMEM51 PF15345.6 ETO28059.1 - 6.2 6.6 13.6 7.7 6.3 13.6 1.1 1 0 0 1 1 1 0 Transmembrane protein 51 DUF908 PF06012.12 ETO28059.1 - 8 5.8 10.5 8.9 5.6 10.5 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) HAD_2 PF13419.6 ETO28060.1 - 0.011 15.8 0.0 0.03 14.4 0.0 1.7 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase DUF2064 PF09837.9 ETO28060.1 - 0.15 11.9 0.1 35 4.2 0.0 2.9 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2064) SWI-SNF_Ssr4 PF08549.10 ETO28060.1 - 0.3 9.7 13.1 0.43 9.2 13.1 1.2 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Macoilin PF09726.9 ETO28060.1 - 1.6 7.2 18.6 2.1 6.8 18.6 1.2 1 0 0 1 1 1 0 Macoilin family Zip PF02535.22 ETO28060.1 - 8.4 5.5 8.1 20 4.2 7.9 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter Peptidase_M1 PF01433.20 ETO28061.1 - 1.3e-51 175.3 1.3 1.5e-51 175.1 1.3 1.0 1 0 0 1 1 1 1 Peptidase family M1 domain Aminopep PF10023.9 ETO28061.1 - 0.0086 15.5 0.0 0.013 14.9 0.0 1.2 1 0 0 1 1 1 1 Putative aminopeptidase zf-C3HC4_3 PF13920.6 ETO28062.1 - 1.2e-12 47.5 13.5 1.9e-12 46.9 13.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO28062.1 - 7.1e-06 25.8 14.9 1.3e-05 25.0 14.9 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ETO28062.1 - 0.0021 17.9 14.5 0.0025 17.6 12.7 2.1 1 1 1 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO28062.1 - 0.013 15.4 14.0 0.024 14.6 14.0 1.4 1 0 0 1 1 1 0 zinc-RING finger domain Presenilin PF01080.17 ETO28062.1 - 0.2 10.4 1.7 0.22 10.3 1.7 1.1 1 0 0 1 1 1 0 Presenilin MMU163 PF17119.5 ETO28062.1 - 0.74 8.9 2.9 0.95 8.6 2.9 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis G-alpha PF00503.20 ETO28063.1 - 4.7e-29 101.6 2.9 6.7e-29 101.1 2.9 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO28063.1 - 2.4e-05 23.9 0.1 5.6e-05 22.7 0.1 1.6 1 0 0 1 1 1 1 ADP-ribosylation factor family DUF4672 PF15716.5 ETO28063.1 - 0.032 13.9 1.6 0.055 13.1 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) DUF4083 PF13314.6 ETO28063.1 - 0.065 13.2 0.1 0.16 11.9 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4083) PepSY_TM_like_2 PF16357.5 ETO28063.1 - 0.11 12.5 0.5 0.23 11.4 0.5 1.5 1 0 0 1 1 1 0 Putative PepSY_TM-like Tudor_2 PF18104.1 ETO28063.1 - 0.21 11.3 0.0 0.21 11.3 0.0 2.0 2 0 0 2 2 2 0 Jumonji domain-containing protein 2A Tudor domain Cation_efflux PF01545.21 ETO28064.1 - 2.4e-28 99.2 12.9 3.2e-28 98.8 12.9 1.1 1 0 0 1 1 1 1 Cation efflux family Glycophorin_A PF01102.18 ETO28064.1 - 0.061 13.6 0.6 0.14 12.4 0.5 1.7 2 0 0 2 2 2 0 Glycophorin A G-alpha PF00503.20 ETO28065.1 - 5.5e-16 58.7 13.7 2.6e-12 46.6 0.9 3.3 3 2 0 3 3 3 2 G-protein alpha subunit SUIM_assoc PF16619.5 ETO28065.1 - 0.034 14.2 0.4 0.034 14.2 0.4 3.2 2 1 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 DUF3439 PF11921.8 ETO28065.1 - 0.052 13.5 3.0 0.13 12.2 3.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MRP-S34 PF16053.5 ETO28065.1 - 0.078 12.6 0.2 0.2 11.3 0.2 1.6 1 0 0 1 1 1 0 Mitochondrial 28S ribosomal protein S34 YwpF PF14183.6 ETO28065.1 - 0.096 12.7 0.3 0.096 12.7 0.3 2.0 2 0 0 2 2 2 0 YwpF-like protein DUF1667 PF07892.11 ETO28065.1 - 0.11 12.5 0.0 0.22 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1667) Cation_efflux PF01545.21 ETO28067.1 - 1e-14 54.7 5.2 1e-14 54.7 5.2 1.7 2 0 0 2 2 2 1 Cation efflux family 2OG-FeII_Oxy_3 PF13640.6 ETO28068.1 - 1.8e-07 31.9 0.0 9.9e-07 29.6 0.0 2.1 2 1 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DUF621 PF04789.15 ETO28068.1 - 0.051 12.7 0.1 0.077 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF621) DUF5548 PF17702.1 ETO28068.1 - 0.1 12.3 0.0 0.3 10.8 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5548) RNA_pol_3_Rpc31 PF11705.8 ETO28069.1 - 5.1 7.3 14.2 0.1 12.9 7.0 1.7 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 BSP_II PF05432.11 ETO28070.1 - 0.0022 17.8 11.4 0.0025 17.6 11.4 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Dzip-like_N PF13815.6 ETO28070.1 - 0.0062 16.5 2.4 0.0071 16.3 0.9 1.8 2 0 0 2 2 2 1 Iguana/Dzip1-like DAZ-interacting protein N-terminal PI3K_1B_p101 PF10486.9 ETO28070.1 - 0.033 12.0 6.1 0.038 11.8 6.1 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Sporozoite_P67 PF05642.11 ETO28070.1 - 0.056 11.5 8.0 0.069 11.2 8.0 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Zip PF02535.22 ETO28070.1 - 0.083 12.1 1.4 0.085 12.1 1.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO28070.1 - 0.086 11.1 7.0 0.1 10.9 7.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO28070.1 - 0.13 10.5 11.3 0.15 10.3 11.3 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO28070.1 - 0.39 10.1 13.5 0.48 9.8 13.5 1.1 1 0 0 1 1 1 0 SDA1 MscS_TM PF12794.7 ETO28070.1 - 0.47 9.3 1.6 0.62 8.9 1.6 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Ferlin_C PF16165.5 ETO28070.1 - 0.52 10.3 3.1 0.76 9.7 3.1 1.4 1 0 0 1 1 1 0 Ferlin C-terminus ANAPC15 PF15243.6 ETO28070.1 - 0.52 10.8 16.2 0.24 11.8 10.0 2.3 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 DNA_pol_phi PF04931.13 ETO28070.1 - 0.54 8.3 16.3 0.72 7.9 16.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO28070.1 - 1.2 7.8 5.1 1.4 7.6 5.1 1.1 1 0 0 1 1 1 0 Presenilin RNA_pol_3_Rpc31 PF11705.8 ETO28070.1 - 1.4 9.2 14.5 0.45 10.7 10.8 1.8 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 LMBR1 PF04791.16 ETO28070.1 - 1.9 7.3 4.3 2.3 7.0 4.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein O-ag_pol_Wzy PF14296.6 ETO28071.1 - 0.06 12.0 3.1 0.071 11.7 3.1 1.1 1 0 0 1 1 1 0 O-antigen polysaccharide polymerase Wzy Peptidase_S49_N PF08496.10 ETO28071.1 - 4.5 7.3 7.5 21 5.2 4.2 2.0 1 1 1 2 2 2 0 Peptidase family S49 N-terminal SCAB-Ig PF16709.5 ETO28072.1 - 6e-05 23.0 0.0 0.00018 21.5 0.0 1.8 1 0 0 1 1 1 1 Ig domain of plant-specific actin-binding protein Coat_X PF07552.11 ETO28072.1 - 0.039 13.8 0.8 0.76 9.6 0.1 2.5 2 0 0 2 2 2 0 Spore Coat Protein X and V domain DUF3060 PF11259.8 ETO28074.1 - 0.09 12.5 0.0 0.42 10.4 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3060) AT_hook PF02178.19 ETO28074.1 - 0.36 10.9 4.4 0.76 9.9 4.4 1.6 1 0 0 1 1 1 0 AT hook motif NB-ARC PF00931.22 ETO28075.1 - 9.7e-06 24.9 2.7 0.0026 17.0 0.0 3.3 3 0 0 3 3 3 2 NB-ARC domain CHAT PF12770.7 ETO28075.1 - 3.6e-05 23.3 0.0 0.00073 19.0 0.0 2.3 1 1 1 2 2 2 1 CHAT domain NACHT PF05729.12 ETO28075.1 - 0.00022 21.2 0.1 0.0021 18.0 0.0 2.7 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 ETO28075.1 - 0.013 15.9 3.5 0.017 15.5 0.4 2.8 2 1 0 2 2 2 0 AAA ATPase domain Mito_fiss_reg PF05308.11 ETO28075.1 - 0.036 14.2 6.8 0.1 12.6 3.2 2.5 2 0 0 2 2 2 0 Mitochondrial fission regulator Raptor_N PF14538.6 ETO28075.1 - 0.12 12.3 1.9 3.7 7.5 0.0 3.4 3 1 0 3 3 3 0 Raptor N-terminal CASPase like domain Pkinase PF00069.25 ETO28076.1 - 1.4e-14 54.2 0.0 1.6e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28076.1 - 0.0053 16.1 0.0 0.0064 15.8 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase UCH PF00443.29 ETO28077.1 - 8.4e-36 123.8 2.7 8.4e-36 123.8 2.7 1.9 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO28077.1 - 4.1e-11 43.0 4.2 4.1e-11 43.0 4.2 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Peptidase_A8 PF01252.18 ETO28077.1 - 0.018 15.3 1.9 0.024 14.9 0.1 2.1 2 0 0 2 2 2 0 Signal peptidase (SPase) II AMPKBI PF04739.15 ETO28077.1 - 0.2 11.9 3.1 0.38 11.1 1.6 2.2 2 0 0 2 2 2 0 5'-AMP-activated protein kinase beta subunit, interaction domain DUF4834 PF16118.5 ETO28077.1 - 2.2 9.3 5.0 4.9 8.2 0.3 3.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) BIR PF00653.21 ETO28077.1 - 6.2 7.6 7.5 0.54 10.9 0.2 2.9 3 0 0 3 3 3 0 Inhibitor of Apoptosis domain OSK PF17182.4 ETO28079.1 - 0.085 12.1 0.4 0.15 11.2 0.1 1.6 2 0 0 2 2 2 0 OSK domain PPR_long PF17177.4 ETO28081.1 - 9.6e-07 28.4 5.8 0.00034 20.0 0.8 3.4 3 0 0 3 3 3 2 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 ETO28081.1 - 0.00011 22.2 4.2 1.7 8.8 0.0 5.5 6 1 1 7 7 7 2 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO28081.1 - 0.00029 21.0 6.4 11 6.3 0.0 6.5 5 1 1 6 6 6 1 PPR repeat family PPR PF01535.20 ETO28081.1 - 0.0045 17.1 1.2 33 5.0 0.0 5.0 4 1 0 4 4 4 0 PPR repeat RapH_N PF18801.1 ETO28081.1 - 0.046 13.8 0.1 0.15 12.2 0.1 1.8 1 0 0 1 1 1 0 response regulator aspartate phosphatase H, N terminal DUF1972 PF09314.11 ETO28081.1 - 0.059 12.9 0.0 0.12 12.0 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1972) SpoIIIAH PF12685.7 ETO28081.1 - 0.15 11.9 2.5 0.22 11.3 0.1 2.0 2 0 0 2 2 2 0 SpoIIIAH-like protein zf-C3Hc3H PF13891.6 ETO28081.1 - 0.15 12.4 7.6 0.46 10.9 0.1 3.4 3 0 0 3 3 3 0 Potential DNA-binding domain Pox_P21 PF05313.12 ETO28082.1 - 0.044 13.3 0.0 0.061 12.9 0.0 1.2 1 0 0 1 1 1 0 Poxvirus P21 membrane protein Wzy_C_2 PF11846.8 ETO28082.1 - 0.1 12.5 0.0 0.16 11.9 0.0 1.3 1 0 0 1 1 1 0 Virulence factor membrane-bound polymerase, C-terminal OapA_N PF08525.11 ETO28082.1 - 0.17 11.9 5.7 0.31 11.0 5.7 1.4 1 0 0 1 1 1 0 Opacity-associated protein A N-terminal motif Sulfotransfer_1 PF00685.27 ETO28083.1 - 2.8e-05 23.7 0.3 8.8e-05 22.1 0.3 1.8 1 1 0 1 1 1 1 Sulfotransferase domain MBOAT_2 PF13813.6 ETO28083.1 - 0.036 14.3 1.7 0.087 13.1 1.7 1.6 1 0 0 1 1 1 0 Membrane bound O-acyl transferase family Dus PF01207.17 ETO28084.1 - 4.7e-55 186.9 0.9 6.2e-55 186.5 0.9 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ETO28084.1 - 0.0014 18.1 0.0 0.0031 17.0 0.0 1.5 1 1 0 1 1 1 1 Histidine biosynthesis protein TMP-TENI PF02581.17 ETO28084.1 - 0.031 13.6 0.0 0.12 11.7 0.0 1.9 2 0 0 2 2 2 0 Thiamine monophosphate synthase BKACE PF05853.12 ETO28084.1 - 0.17 11.2 0.0 0.27 10.5 0.0 1.3 1 0 0 1 1 1 0 beta-keto acid cleavage enzyme PEP_hydrolase PF09370.10 ETO28084.1 - 0.18 11.0 0.0 3.3 6.8 0.0 2.4 2 1 0 2 2 2 0 Phosphoenolpyruvate hydrolase-like Arm PF00514.23 ETO28087.1 - 1.9e-10 40.4 0.1 4.1e-05 23.5 0.0 3.4 3 0 0 3 3 3 2 Armadillo/beta-catenin-like repeat HEAT_EZ PF13513.6 ETO28087.1 - 6.4e-05 23.4 0.0 0.00028 21.3 0.0 2.0 2 0 0 2 2 2 1 HEAT-like repeat DUF2722 PF10846.8 ETO28087.1 - 0.42 9.5 3.2 0.42 9.5 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DNA_pol_phi PF04931.13 ETO28087.1 - 2.5 6.1 21.1 3.9 5.5 21.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi FAM176 PF14851.6 ETO28087.1 - 2.8 7.6 9.7 4.2 7.0 9.7 1.3 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 ETO28087.1 - 5.2 7.1 11.3 7.8 6.5 11.3 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal CENP-B_dimeris PF09026.10 ETO28087.1 - 5.9 7.4 15.3 14 6.2 15.3 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain RRM_1 PF00076.22 ETO28089.1 - 1.2e-07 31.4 0.1 2.5e-07 30.4 0.1 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SSP160 PF06933.11 ETO28089.1 - 7.4 4.6 16.2 11 4.1 16.2 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 RRM_1 PF00076.22 ETO28090.1 - 5.5e-15 55.0 0.0 1.1e-14 54.0 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM PF05172.13 ETO28090.1 - 0.001 19.0 0.1 0.0026 17.7 0.1 1.7 1 1 0 1 1 1 1 Nup53/35/40-type RNA recognition motif Limkain-b1 PF11608.8 ETO28090.1 - 0.074 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 Limkain b1 RRM_1 PF00076.22 ETO28091.1 - 1.1e-20 73.2 0.0 3e-17 62.2 0.0 2.6 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO28091.1 - 4.1e-06 26.6 0.0 0.0018 18.1 0.0 3.5 4 1 1 5 5 5 1 Occluded RNA-recognition motif RRM_5 PF13893.6 ETO28091.1 - 0.00014 21.4 0.0 0.00025 20.6 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WWE PF02825.20 ETO28091.1 - 0.00062 20.3 0.0 0.0015 19.1 0.0 1.7 1 0 0 1 1 1 1 WWE domain RRM_7 PF16367.5 ETO28091.1 - 0.13 12.3 0.0 0.59 10.3 0.0 2.2 1 1 0 1 1 1 0 RNA recognition motif F-box-like PF12937.7 ETO28093.1 - 0.0032 17.3 0.0 0.015 15.1 0.0 2.2 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO28093.1 - 0.1 12.5 1.2 0.39 10.7 0.0 2.5 3 0 0 3 3 3 0 F-box domain Ribosomal_S28e PF01200.18 ETO28095.1 - 4.6e-27 93.8 0.1 6.2e-27 93.4 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein S28e HSP70 PF00012.20 ETO28096.1 - 3.2e-93 312.9 18.0 1.6e-83 280.9 0.1 3.1 2 1 0 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO28096.1 - 1.3e-05 24.2 0.0 0.00012 21.0 0.0 2.4 3 0 0 3 3 3 1 MreB/Mbl protein DUF4834 PF16118.5 ETO28096.1 - 2.2 9.3 7.6 11 7.1 4.7 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF913 PF06025.12 ETO28096.1 - 6.9 5.5 8.7 2.8 6.9 5.8 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) HSP70 PF00012.20 ETO28097.1 - 7.4e-08 31.0 0.8 7.4e-08 31.0 0.8 2.2 2 1 1 3 3 3 1 Hsp70 protein CHAD PF05235.14 ETO28097.1 - 0.014 15.4 1.5 0.024 14.6 1.5 1.3 1 0 0 1 1 1 0 CHAD domain TonB_N PF16031.5 ETO28097.1 - 0.017 15.6 33.5 0.02 15.4 32.7 1.5 1 1 0 1 1 1 0 TonB polyproline region Trypan_PARP PF05887.11 ETO28097.1 - 0.38 10.7 22.5 0.7 9.9 22.5 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) CCDC53 PF10152.9 ETO28097.1 - 0.44 10.9 12.2 0.8 10.1 12.2 1.6 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex DUF1664 PF07889.12 ETO28097.1 - 0.81 9.7 2.8 6.7 6.8 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) FAP PF07174.11 ETO28097.1 - 8.2 5.8 10.8 11 5.3 10.8 1.1 1 0 0 1 1 1 0 Fibronectin-attachment protein (FAP) DUF5496 PF17600.2 ETO28099.1 - 0.077 13.0 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5496) EF-hand_1 PF00036.32 ETO28099.1 - 0.085 12.4 0.6 0.56 9.9 0.1 2.2 2 0 0 2 2 2 0 EF hand LRR_8 PF13855.6 ETO28100.1 - 8.5e-06 25.4 0.1 4.5e-05 23.1 0.1 2.2 2 0 0 2 2 2 1 Leucine rich repeat Nop14 PF04147.12 ETO28102.1 - 0.0065 14.7 14.9 0.0076 14.5 14.9 1.1 1 0 0 1 1 1 1 Nop14-like family Mpp10 PF04006.12 ETO28102.1 - 0.0094 14.5 16.5 0.01 14.3 16.5 1.0 1 0 0 1 1 1 1 Mpp10 protein SDA1 PF05285.12 ETO28102.1 - 0.0094 15.4 13.9 0.01 15.3 13.9 1.1 1 0 0 1 1 1 1 SDA1 CDC45 PF02724.14 ETO28102.1 - 0.023 13.0 10.8 0.024 13.0 10.8 1.1 1 0 0 1 1 1 0 CDC45-like protein Svs_4_5_6 PF17381.2 ETO28102.1 - 0.054 14.5 1.2 0.054 14.5 1.2 1.8 2 0 0 2 2 2 0 Seminal vesicle secretory proteins 4/5/6 RPN2_C PF18004.1 ETO28102.1 - 0.16 11.8 4.8 0.27 11.1 4.8 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ETO28102.1 - 0.21 10.3 2.2 0.23 10.2 2.2 1.1 1 0 0 1 1 1 0 Presenilin PPP4R2 PF09184.11 ETO28102.1 - 0.24 11.0 15.8 0.32 10.5 15.8 1.2 1 0 0 1 1 1 0 PPP4R2 GOLD_2 PF13897.6 ETO28102.1 - 0.5 10.9 7.5 0.8 10.2 7.5 1.3 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Tim54 PF11711.8 ETO28102.1 - 0.6 8.8 3.7 0.77 8.5 3.7 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 PDCD2_C PF04194.13 ETO28102.1 - 0.62 10.1 9.7 1.1 9.3 9.7 1.3 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain BUD22 PF09073.10 ETO28102.1 - 0.79 9.0 12.0 0.92 8.8 12.0 1.2 1 0 0 1 1 1 0 BUD22 RNA_pol_Rpc4 PF05132.14 ETO28102.1 - 1.1 9.7 3.7 1.7 9.1 3.7 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 EFTUD2 PF16004.5 ETO28102.1 - 1.1 9.9 23.5 1.9 9.1 23.5 1.4 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Zip PF02535.22 ETO28102.1 - 2 7.5 5.8 2.4 7.3 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5523 PF17661.1 ETO28102.1 - 5.6 6.6 14.3 7.7 6.1 14.3 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) NPR3 PF03666.13 ETO28102.1 - 5.9 5.6 8.8 7.9 5.2 8.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PABP PF00658.18 ETO28103.1 - 4.8e-09 36.3 0.0 8.5e-09 35.5 0.0 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Spore_coat_CotO PF14153.6 ETO28103.1 - 0.0027 17.7 5.6 0.0038 17.2 5.6 1.2 1 0 0 1 1 1 1 Spore coat protein CotO DUF2201_N PF13203.6 ETO28103.1 - 0.045 13.3 0.7 0.061 12.9 0.7 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain RNA_pol_Rpc4 PF05132.14 ETO28103.1 - 0.047 14.1 1.5 0.066 13.7 1.5 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop14 PF04147.12 ETO28103.1 - 0.92 7.6 12.3 1.1 7.4 12.3 1.1 1 0 0 1 1 1 0 Nop14-like family Cwf_Cwc_15 PF04889.12 ETO28103.1 - 1.8 8.2 14.6 2.2 7.9 14.6 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein CobT PF06213.12 ETO28103.1 - 2.5 7.4 12.1 3.4 7.0 12.1 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CDC45 PF02724.14 ETO28103.1 - 2.9 6.1 8.7 3.4 5.8 8.7 1.1 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ETO28103.1 - 3.4 6.9 12.8 4.4 6.5 12.8 1.1 1 0 0 1 1 1 0 NOA36 protein Imm42 PF15593.6 ETO28105.1 - 0.0085 16.6 0.5 0.011 16.2 0.5 1.2 1 0 0 1 1 1 1 Immunity protein 42 PTB PF08416.13 ETO28105.1 - 0.081 13.1 0.1 0.1 12.8 0.1 1.1 1 0 0 1 1 1 0 Phosphotyrosine-binding domain DUSP PF06337.12 ETO28105.1 - 0.096 13.3 0.2 0.12 13.0 0.2 1.3 1 0 0 1 1 1 0 DUSP domain MscL PF01741.18 ETO28106.1 - 0.27 11.6 1.2 3.8 7.8 0.1 2.4 2 0 0 2 2 2 0 Large-conductance mechanosensitive channel, MscL Saf_2TM PF18303.1 ETO28106.1 - 0.32 10.6 1.9 1.6 8.3 0.3 2.5 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain Synaptobrevin PF00957.21 ETO28107.1 - 3.4e-09 36.4 0.2 1e-08 34.8 0.2 1.8 1 0 0 1 1 1 1 Synaptobrevin Sulfate_transp PF00916.20 ETO28109.1 - 2.2e-22 79.3 1.0 3.5e-22 78.7 1.0 1.2 1 0 0 1 1 1 1 Sulfate permease family FtsX PF02687.21 ETO28109.1 - 0.27 11.7 4.8 4.8 7.7 1.3 2.5 2 0 0 2 2 2 0 FtsX-like permease family DUF4199 PF13858.6 ETO28109.1 - 0.97 9.8 7.3 8.1 6.8 1.2 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF4199) Ras PF00071.22 ETO28110.1 - 7.6e-39 132.9 5.0 3e-21 75.7 0.2 3.1 1 1 1 3 3 3 3 Ras family Roc PF08477.13 ETO28110.1 - 3.6e-13 49.8 0.8 1.2e-07 32.0 0.3 2.6 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO28110.1 - 0.064 12.7 0.2 5.7 6.4 0.0 2.2 2 0 0 2 2 2 0 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO28110.1 - 0.08 12.8 0.2 0.41 10.5 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase PsaD PF02531.16 ETO28110.1 - 0.091 12.3 2.9 2.9 7.4 0.1 2.5 3 0 0 3 3 3 0 PsaD MMR_HSR1 PF01926.23 ETO28110.1 - 0.35 11.0 1.2 2.9 8.0 1.2 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase BPL_N PF09825.9 ETO28112.1 - 0.35 9.9 8.4 0.37 9.8 8.4 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal Asparaginase_2 PF01112.18 ETO28112.1 - 4.7 6.2 6.2 5.6 5.9 6.2 1.1 1 0 0 1 1 1 0 Asparaginase DUF1523 PF07509.11 ETO28113.1 - 0.031 13.7 0.1 0.052 12.9 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1523) EMC3_TMCO1 PF01956.16 ETO28113.1 - 0.57 9.9 8.4 0.29 10.9 5.6 1.8 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Radial_spoke_3 PF06098.11 ETO28113.1 - 1.8 7.8 12.5 0.2 10.9 7.7 1.7 2 0 0 2 2 2 0 Radial spoke protein 3 Chorion_2 PF03964.15 ETO28113.1 - 3.4 8.5 6.9 55 4.7 0.0 2.7 2 0 0 2 2 2 0 Chorion family 2 PNISR PF15996.5 ETO28113.1 - 5.5 7.2 15.8 11 6.2 15.8 1.5 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR SHQ1 PF04925.15 ETO28115.1 - 0.001 18.7 0.1 0.0025 17.4 0.1 1.6 1 0 0 1 1 1 1 SHQ1 protein Connexin PF00029.19 ETO28116.1 - 0.0095 15.7 1.1 0.011 15.5 1.1 1.0 1 0 0 1 1 1 1 Connexin sCache_3_3 PF17202.4 ETO28116.1 - 0.33 11.4 2.0 0.55 10.7 0.8 1.8 1 1 1 2 2 2 0 Single cache domain 3 SNARE PF05739.19 ETO28116.1 - 7.7 6.6 11.6 0.13 12.2 2.3 2.7 3 0 0 3 3 3 0 SNARE domain RRM_1 PF00076.22 ETO28118.1 - 1.1e-39 134.1 11.2 6.8e-18 64.3 0.4 4.4 5 1 0 5 5 5 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) SET_assoc PF11767.8 ETO28118.1 - 4.6e-05 23.0 1.5 0.047 13.3 0.0 3.5 3 0 0 3 3 3 2 Histone lysine methyltransferase SET associated Nup35_RRM_2 PF14605.6 ETO28118.1 - 4.8e-05 23.3 1.9 4.3 7.4 0.0 3.5 3 0 0 3 3 3 3 Nup53/35/40-type RNA recognition motif RRM_3 PF08777.11 ETO28118.1 - 0.00064 19.7 10.5 1.2 9.2 0.0 4.3 4 0 0 4 4 4 2 RNA binding motif RRM_occluded PF16842.5 ETO28118.1 - 0.008 16.0 0.0 0.36 10.7 0.0 2.7 2 0 0 2 2 2 1 Occluded RNA-recognition motif RRM_7 PF16367.5 ETO28118.1 - 0.036 14.2 5.5 10 6.3 0.0 4.4 4 0 0 4 4 4 0 RNA recognition motif PHM7_cyt PF14703.6 ETO28118.1 - 0.048 13.9 0.0 0.048 13.9 0.0 4.2 2 1 0 2 2 1 0 Cytosolic domain of 10TM putative phosphate transporter Cauli_DNA-bind PF03310.13 ETO28118.1 - 0.092 12.8 1.5 0.21 11.7 1.5 1.5 1 0 0 1 1 1 0 Caulimovirus DNA-binding protein Exonuc_VII_L PF02601.15 ETO28118.1 - 0.51 9.9 12.3 0.84 9.1 12.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 ETO28118.1 - 2.2 7.1 3.6 2.4 7.0 3.6 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Lin-8 PF03353.15 ETO28118.1 - 3.6 7.0 19.8 4.6 6.7 17.8 2.0 2 0 0 2 2 2 0 Ras-mediated vulval-induction antagonist DUF4407 PF14362.6 ETO28118.1 - 4.5 6.5 7.2 7.6 5.8 7.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Arm-DNA-bind_4 PF14657.6 ETO28118.1 - 5.4 6.9 7.0 7.3 6.4 1.2 2.6 2 0 0 2 2 2 0 Arm DNA-binding domain FAM176 PF14851.6 ETO28120.1 - 0.24 11.0 0.7 0.36 10.5 0.7 1.2 1 0 0 1 1 1 0 FAM176 family Ig_J_chain PF15097.6 ETO28125.1 - 0.03 14.2 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 Immunoglobulin J chain DUF569 PF04601.13 ETO28126.1 - 0.12 12.1 0.1 0.8 9.4 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF569) TPKR_C2 PF16920.5 ETO28126.1 - 4.6 7.4 5.4 65 3.8 1.0 3.1 3 0 0 3 3 3 0 Tyrosine-protein kinase receptor C2 Ig-like domain PADR1 PF08063.12 ETO28127.1 - 0.00011 21.9 7.4 0.00011 21.9 7.4 2.6 2 1 0 2 2 2 1 PADR1 (NUC008) domain SAP PF02037.27 ETO28127.1 - 0.00016 21.3 0.2 0.00016 21.3 0.2 2.4 3 0 0 3 3 3 1 SAP domain VWA PF00092.28 ETO28127.1 - 0.00042 20.6 0.0 0.0018 18.5 0.0 2.0 1 1 0 1 1 1 1 von Willebrand factor type A domain zf-HC5HC2H PF13771.6 ETO28127.1 - 0.055 13.7 0.7 0.19 12.0 0.7 2.0 1 0 0 1 1 1 0 PHD-like zinc-binding domain LAP1C PF05609.12 ETO28128.1 - 1.5e-05 24.3 7.0 2.1e-05 23.8 7.0 1.1 1 0 0 1 1 1 1 Lamina-associated polypeptide 1C (LAP1C) DUF2457 PF10446.9 ETO28128.1 - 0.16 11.1 18.2 0.3 10.2 18.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO28128.1 - 3.7 5.6 21.6 5.3 5.1 21.6 1.3 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO28128.1 - 7 4.8 16.3 9.1 4.4 16.3 1.2 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO28129.1 - 4.3e-14 52.7 1.5 1.5e-05 25.7 0.2 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO28129.1 - 0.00028 19.7 1.3 0.041 12.5 0.3 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO28129.1 - 0.0024 18.1 0.1 0.11 12.8 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO28129.1 - 0.0068 15.2 2.2 0.045 12.5 0.2 2.1 1 1 1 2 2 2 1 Nup133 N terminal like XhlA PF10779.9 ETO28129.1 - 1.8 8.8 8.9 3.4 7.9 8.9 1.4 1 0 0 1 1 1 0 Haemolysin XhlA VWA_3 PF13768.6 ETO28130.1 - 2.3e-07 30.9 0.0 1.2e-06 28.6 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO28130.1 - 0.084 13.5 0.0 0.16 12.7 0.0 1.5 1 0 0 1 1 1 0 von Willebrand factor type A domain ANAPC4_WD40 PF12894.7 ETO28131.1 - 0.00072 19.8 1.7 0.12 12.7 0.2 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO28131.1 - 0.0011 19.8 4.4 0.0067 17.3 0.3 3.2 3 0 0 3 3 3 1 WD domain, G-beta repeat Herpes_UL47 PF03362.13 ETO28131.1 - 0.093 11.5 0.1 0.14 10.9 0.1 1.1 1 0 0 1 1 1 0 Herpesvirus UL47 protein Syntaxin-5_N PF11416.8 ETO28131.1 - 0.13 11.5 0.3 0.22 10.8 0.3 1.4 1 0 0 1 1 1 0 Syntaxin-5 N-terminal, Sly1p-binding domain SET PF00856.28 ETO28132.1 - 0.091 13.1 0.1 0.091 13.1 0.1 2.0 2 1 0 2 2 2 0 SET domain V-SNARE_C PF12352.8 ETO28133.1 - 8.8e-10 38.7 3.0 1.1e-09 38.4 3.0 1.2 1 0 0 1 1 1 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO28133.1 - 6.4e-07 29.2 0.2 8.2e-07 28.9 0.2 1.1 1 0 0 1 1 1 1 Sec20 Laminin_II PF06009.12 ETO28133.1 - 0.0044 17.0 1.3 0.0062 16.6 1.3 1.1 1 0 0 1 1 1 1 Laminin Domain II Fusion_gly PF00523.18 ETO28133.1 - 0.0047 15.2 0.3 0.0051 15.1 0.3 1.1 1 0 0 1 1 1 1 Fusion glycoprotein F0 SNARE PF05739.19 ETO28133.1 - 0.0073 16.3 2.9 0.0073 16.3 2.9 1.8 2 0 0 2 2 2 1 SNARE domain EMP24_GP25L PF01105.24 ETO28133.1 - 0.016 15.1 1.0 0.019 14.9 1.0 1.1 1 0 0 1 1 1 0 emp24/gp25L/p24 family/GOLD Muted PF14942.6 ETO28133.1 - 0.019 15.3 1.3 0.025 14.9 1.3 1.1 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein DUF3160 PF11369.8 ETO28133.1 - 0.043 12.3 0.2 0.049 12.1 0.2 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3160) IFT57 PF10498.9 ETO28133.1 - 0.046 12.7 2.3 0.052 12.5 2.3 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 Mobilization_B PF17511.2 ETO28133.1 - 0.046 14.1 0.1 0.055 13.8 0.1 1.1 1 0 0 1 1 1 0 Mobilization protein B DUF4079 PF13301.6 ETO28133.1 - 0.086 13.0 0.0 0.11 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4079) DUF4094 PF13334.6 ETO28133.1 - 0.17 12.3 3.0 0.2 12.1 1.6 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) MtrG PF04210.13 ETO28133.1 - 0.2 11.6 1.9 0.23 11.4 1.0 1.7 1 1 1 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF2721 PF11026.8 ETO28133.1 - 0.26 11.2 5.8 0.78 9.6 5.8 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2721) MRPL52 PF18699.1 ETO28133.1 - 0.99 9.6 4.9 1.2 9.4 3.7 1.7 1 1 1 2 2 2 0 Mitoribosomal protein mL52 DUF1003 PF06210.11 ETO28133.1 - 1.3 9.1 8.9 0.77 9.9 4.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1003) DUF4199 PF13858.6 ETO28133.1 - 1.6 9.1 6.0 7.9 6.8 6.4 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF4199) DUF4446 PF14584.6 ETO28133.1 - 3.9 7.4 10.6 1.1 9.2 2.7 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) Neur_chan_memb PF02932.16 ETO28133.1 - 6.7 6.7 8.5 0.94 9.5 2.3 1.9 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SIKE PF05769.11 ETO28134.1 - 0.0075 16.2 2.2 0.011 15.7 2.2 1.4 1 1 0 1 1 1 1 SIKE family XhlA PF10779.9 ETO28134.1 - 0.014 15.6 0.3 0.014 15.6 0.3 1.9 2 0 0 2 2 2 0 Haemolysin XhlA Cauli_AT PF03233.13 ETO28134.1 - 0.016 15.2 1.5 0.025 14.5 1.2 1.5 1 1 1 2 2 2 0 Aphid transmission protein DUF5339 PF17274.2 ETO28134.1 - 0.019 15.8 1.2 0.038 14.8 0.2 2.0 1 1 1 2 2 2 0 Family of unknown function (DUF5339) SesA PF17107.5 ETO28134.1 - 0.019 15.2 0.3 0.021 15.0 0.3 1.2 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases V-SNARE PF05008.15 ETO28134.1 - 0.021 15.2 4.4 0.044 14.2 4.4 1.5 1 1 0 1 1 1 0 Vesicle transport v-SNARE protein N-terminus Laminin_I PF06008.14 ETO28134.1 - 0.024 14.3 3.5 0.36 10.5 0.5 2.1 1 1 1 2 2 2 0 Laminin Domain I Occludin_ELL PF07303.13 ETO28134.1 - 0.032 14.9 3.6 3.8 8.3 0.2 2.1 1 1 1 2 2 2 0 Occludin homology domain CAF20 PF17052.5 ETO28134.1 - 0.087 13.0 3.9 0.048 13.8 1.1 1.8 1 1 1 2 2 2 0 Cap associated factor Uso1_p115_C PF04871.13 ETO28134.1 - 0.15 12.4 5.7 1.8 9.0 5.7 2.1 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Tropomyosin_1 PF12718.7 ETO28134.1 - 0.18 12.0 6.3 0.032 14.4 2.2 1.7 2 0 0 2 2 2 0 Tropomyosin like DUF2730 PF10805.8 ETO28134.1 - 0.19 11.8 1.9 1.7 8.8 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) DUF2203 PF09969.9 ETO28134.1 - 0.21 12.3 3.7 0.51 11.1 3.7 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) Spectrin PF00435.21 ETO28134.1 - 0.42 11.1 8.2 4.5 7.8 1.1 2.5 1 1 0 2 2 2 0 Spectrin repeat FlxA PF14282.6 ETO28134.1 - 8.5 6.4 10.7 1 9.4 1.9 2.3 1 1 1 2 2 2 0 FlxA-like protein SnoaL_2 PF12680.7 ETO28135.1 - 8e-05 23.2 0.0 0.00017 22.2 0.0 1.6 1 0 0 1 1 1 1 SnoaL-like domain Selenoprotein_S PF06936.11 ETO28135.1 - 0.0014 18.5 9.6 0.011 15.6 8.3 2.2 2 0 0 2 2 2 1 Selenoprotein S (SelS) SnoaL PF07366.12 ETO28135.1 - 0.026 14.3 0.0 0.073 12.9 0.0 1.7 1 1 0 1 1 1 0 SnoaL-like polyketide cyclase Adeno_knob PF00541.17 ETO28135.1 - 0.054 13.2 0.1 0.12 12.0 0.1 1.5 1 0 0 1 1 1 0 Adenoviral fibre protein (knob domain) CRAL_TRIO PF00650.20 ETO28137.1 - 7.9e-12 45.2 0.2 9.7e-12 44.9 0.2 1.1 1 0 0 1 1 1 1 CRAL/TRIO domain Pannexin_like PF12534.8 ETO28138.1 - 0.029 13.4 1.7 0.029 13.4 1.7 1.5 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 VPS9 PF02204.18 ETO28139.1 - 3.8e-07 30.3 1.5 3.2e-06 27.3 1.5 2.5 1 1 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain MFS_Mycoplasma PF07672.13 ETO28139.1 - 0.0025 17.2 4.6 0.052 12.8 1.0 2.6 2 0 0 2 2 2 2 Mycoplasma MFS transporter Ammonium_transp PF00909.21 ETO28139.1 - 0.023 13.4 0.1 0.044 12.5 0.1 1.4 1 0 0 1 1 1 0 Ammonium Transporter Family YajC PF02699.15 ETO28139.1 - 0.025 14.5 1.3 0.025 14.5 1.3 2.3 3 0 0 3 3 3 0 Preprotein translocase subunit OAD_gamma PF04277.13 ETO28139.1 - 0.058 14.0 5.9 0.48 11.0 1.4 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DEP PF00610.21 ETO28140.1 - 9.4e-08 32.0 0.0 1.8e-07 31.1 0.0 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Inhibitor_I71 PF12628.7 ETO28142.1 - 0.027 14.3 0.2 0.027 14.3 0.2 2.1 1 1 1 2 2 2 0 Falstatin, cysteine peptidase inhibitor ETRAMP PF09716.10 ETO28142.1 - 0.42 10.7 7.0 0.83 9.8 7.0 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Inos-1-P_synth PF01658.17 ETO28142.1 - 1.2 9.4 8.7 1.4 9.2 8.0 1.4 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase PWWP PF00855.17 ETO28142.1 - 1.7 9.1 4.7 3.4 8.2 4.7 1.5 1 1 0 1 1 1 0 PWWP domain Sec62 PF03839.16 ETO28142.1 - 5.7 6.4 8.6 8.3 5.8 8.6 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 FRQ PF09421.10 ETO28143.1 - 0.00017 19.8 7.3 0.00021 19.5 7.3 1.1 1 0 0 1 1 1 1 Frequency clock protein Cwf_Cwc_15 PF04889.12 ETO28143.1 - 0.0062 16.3 16.5 0.012 15.4 16.5 1.5 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein Sporozoite_P67 PF05642.11 ETO28143.1 - 0.29 9.2 4.1 0.37 8.8 4.1 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2457 PF10446.9 ETO28143.1 - 0.5 9.4 16.0 0.91 8.6 16.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO28143.1 - 0.59 8.3 8.7 0.96 7.7 8.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO28143.1 - 0.61 8.2 12.5 0.73 8.0 12.5 1.1 1 0 0 1 1 1 0 Nop14-like family RRN3 PF05327.11 ETO28143.1 - 0.73 8.3 6.3 0.88 8.0 6.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 NOA36 PF06524.12 ETO28143.1 - 3.4 6.9 22.4 1.7 7.9 19.0 2.0 1 1 1 2 2 2 0 NOA36 protein TFIIF_alpha PF05793.12 ETO28143.1 - 4.8 5.7 20.2 0.011 14.4 10.3 1.5 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DNA_pol_phi PF04931.13 ETO28143.1 - 8 4.4 12.2 13 3.7 12.2 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF4834 PF16118.5 ETO28144.1 - 0.11 13.4 5.4 0.12 13.3 5.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) CPP1-like PF11833.8 ETO28144.1 - 0.12 12.0 2.5 0.13 11.9 2.5 1.1 1 0 0 1 1 1 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like DUF3464 PF11947.8 ETO28144.1 - 1.5 8.6 8.7 1.7 8.3 8.7 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Presenilin PF01080.17 ETO28144.1 - 3.6 6.2 5.5 3.8 6.2 5.5 1.1 1 0 0 1 1 1 0 Presenilin PAS_7 PF12860.7 ETO28145.1 - 0.065 13.4 0.1 0.16 12.1 0.0 1.8 2 0 0 2 2 2 0 PAS fold HBS1_N PF08938.10 ETO28146.1 - 0.036 14.4 0.6 0.092 13.1 0.0 2.0 2 0 0 2 2 2 0 HBS1 N-terminus SLED PF12140.8 ETO28146.1 - 0.2 12.2 1.9 0.8 10.2 0.2 2.3 1 1 1 2 2 2 0 SLED domain E3_UbLigase_EDD PF11547.8 ETO28146.1 - 9.9 6.0 7.8 0.25 11.1 1.0 1.8 2 0 0 2 2 2 0 E3 ubiquitin ligase EDD MscS_porin PF12795.7 ETO28147.1 - 0.0031 17.1 0.9 0.0031 17.1 0.9 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain SMODS PF18144.1 ETO28147.1 - 0.021 15.0 0.1 0.023 14.9 0.1 1.1 1 0 0 1 1 1 0 Second Messenger Oligonucleotide or Dinucleotide Synthetase domain Ribosomal_L29 PF00831.23 ETO28147.1 - 0.033 14.2 2.7 0.051 13.5 2.7 1.4 1 0 0 1 1 1 0 Ribosomal L29 protein Med4 PF10018.9 ETO28147.1 - 0.11 12.2 1.0 0.12 12.0 1.0 1.1 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 PDZ_assoc PF10600.9 ETO28148.1 - 0.054 14.3 1.8 0.054 14.3 1.8 2.5 1 1 1 2 2 2 0 PDZ-associated domain of NMDA receptors CSG2 PF16965.5 ETO28148.1 - 2.2 7.1 7.0 0.72 8.7 0.2 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator Ras PF00071.22 ETO28149.1 - 1.1e-26 93.3 0.7 1.5e-25 89.7 0.7 2.3 1 1 0 1 1 1 1 Ras family Roc PF08477.13 ETO28149.1 - 4.9e-10 39.7 0.1 1.8e-09 37.9 0.1 2.0 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO28149.1 - 0.013 15.4 1.6 0.25 11.2 0.1 2.5 3 0 0 3 3 3 0 RsgA GTPase MgtE_N PF03448.17 ETO28149.1 - 0.092 13.4 0.5 0.26 11.9 0.4 1.8 2 0 0 2 2 2 0 MgtE intracellular N domain Holin_BhlA PF10960.8 ETO28150.1 - 0.23 11.4 1.2 17 5.5 0.4 2.4 2 0 0 2 2 2 0 BhlA holin family EPL1 PF10513.9 ETO28152.1 - 0.015 15.7 22.7 0.089 13.2 9.6 2.1 2 0 0 2 2 2 0 Enhancer of polycomb-like DUF1980 PF09323.10 ETO28152.1 - 3.6 7.5 13.6 3.8 7.4 3.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) Menin PF05053.13 ETO28152.1 - 6 5.1 16.1 0.23 9.8 10.0 1.6 2 0 0 2 2 2 0 Menin Beta-TrCP_D PF12125.8 ETO28154.1 - 0.073 13.0 1.0 0.42 10.5 0.0 2.4 2 0 0 2 2 2 0 D domain of beta-TrCP TPR_12 PF13424.6 ETO28155.1 - 0.0049 17.1 0.1 0.25 11.7 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF4796 PF16044.5 ETO28155.1 - 0.0059 16.2 1.6 0.15 11.6 0.4 2.8 2 0 0 2 2 2 1 Domain of unknown function (DUF4796) TPR_2 PF07719.17 ETO28155.1 - 0.011 15.8 2.5 4.6 7.6 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF1803 PF08820.10 ETO28155.1 - 0.016 15.2 0.2 0.12 12.4 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF1803) PH_9 PF15410.6 ETO28155.1 - 0.068 13.5 0.1 0.31 11.4 0.1 2.1 1 1 0 1 1 1 0 Pleckstrin homology domain UBA_3 PF09288.10 ETO28155.1 - 0.069 13.0 0.0 0.23 11.3 0.0 1.9 2 0 0 2 2 2 0 Fungal ubiquitin-associated domain Clr5 PF14420.6 ETO28157.1 - 0.0047 17.1 0.0 0.012 15.8 0.0 1.7 1 0 0 1 1 1 1 Clr5 domain MCM_bind PF09739.9 ETO28158.1 - 2.3e-53 181.6 6.6 2.2e-47 161.8 1.8 3.1 2 1 1 3 3 3 3 Mini-chromosome maintenance replisome factor IMUP PF15761.5 ETO28159.1 - 0.024 15.3 9.0 0.024 15.3 9.0 2.2 2 0 0 2 2 2 0 Immortalisation up-regulated protein RAP1 PF07218.11 ETO28159.1 - 0.19 10.0 4.3 0.27 9.4 4.3 1.2 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) zf-HC5HC2H_2 PF13832.6 ETO28160.1 - 7.3e-10 39.0 7.1 2.1e-09 37.5 7.1 1.7 1 1 0 1 1 1 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO28160.1 - 2.8e-09 37.1 6.4 2.4e-08 34.1 7.0 1.9 1 1 1 2 2 2 1 PHD-like zinc-binding domain PHD PF00628.29 ETO28160.1 - 0.68 9.9 8.4 3.6 7.6 6.5 2.2 2 0 0 2 2 2 0 PHD-finger ALMT PF11744.8 ETO28162.1 - 0.49 9.2 7.3 0.57 8.9 7.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DEAD PF00270.29 ETO28163.1 - 2e-46 158.0 0.0 2.7e-46 157.5 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO28163.1 - 0.00019 21.5 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C PF00271.31 ETO28164.1 - 3.6e-26 91.7 0.7 4.4e-26 91.4 0.7 1.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain ERCC3_RAD25_C PF16203.5 ETO28164.1 - 0.0078 15.4 0.1 0.0091 15.2 0.1 1.1 1 0 0 1 1 1 1 ERCC3/RAD25/XPB C-terminal helicase Git3 PF11710.8 ETO28165.1 - 2.9e-06 27.2 10.1 2.9e-06 27.2 10.1 2.0 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 Dicty_CAR PF05462.11 ETO28165.1 - 0.0082 15.3 17.3 0.38 9.9 17.3 2.6 1 1 0 1 1 1 1 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ETO28165.1 - 7.1 5.8 22.6 3.5 6.8 15.4 2.5 2 1 0 2 2 2 0 7 transmembrane receptor (Secretin family) Drf_GBD PF06371.13 ETO28166.1 - 0.004 16.7 1.8 0.004 16.7 1.8 2.9 2 1 0 2 2 2 1 Diaphanous GTPase-binding Domain zf-C2HCIx2C PF10782.9 ETO28167.1 - 0.28 11.1 1.4 0.78 9.7 1.4 1.7 1 0 0 1 1 1 0 Zinc-finger DUF5347 PF17282.2 ETO28168.1 - 0.17 12.2 1.1 0.79 10.1 0.2 2.4 3 0 0 3 3 3 0 Family of unknown function (DUF5347) Mei4 PF13971.6 ETO28169.1 - 0.011 15.3 5.5 0.037 13.5 3.5 2.1 2 0 0 2 2 2 0 Meiosis-specific protein Mei4 TNT PF14021.6 ETO28171.1 - 0.06 13.9 0.0 0.13 12.9 0.0 1.5 1 0 0 1 1 1 0 Tuberculosis necrotizing toxin DpnI_C PF17726.1 ETO28171.1 - 0.33 11.1 8.3 22 5.3 1.0 4.0 2 1 1 3 3 3 0 Dam-replacing HTH domain DUF4568 PF15132.6 ETO28173.1 - 0.003 16.9 0.0 0.0047 16.3 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4568) DUF4734 PF15881.5 ETO28173.1 - 0.019 15.1 0.0 0.044 13.9 0.0 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4734) FKBP26_C PF18046.1 ETO28173.1 - 0.037 14.1 0.1 0.22 11.6 0.1 2.2 1 1 0 1 1 1 0 FKBP26_C-terminal EF-hand_1 PF00036.32 ETO28174.1 - 0.019 14.5 0.1 0.019 14.5 0.1 2.1 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 ETO28174.1 - 0.027 14.4 0.0 0.027 14.4 0.0 2.4 2 0 0 2 2 2 0 EF-hand domain MFS_1 PF07690.16 ETO28175.1 - 4e-26 91.8 23.8 2e-19 69.8 1.8 2.8 2 1 1 3 3 3 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETO28175.1 - 1.1e-13 50.6 26.6 2.7e-09 36.1 8.3 3.1 3 0 0 3 3 3 3 MFS/sugar transport protein PUCC PF03209.15 ETO28175.1 - 7.5e-06 25.2 7.7 0.0025 16.9 2.9 2.9 2 1 0 2 2 2 2 PUCC protein BT1 PF03092.16 ETO28175.1 - 1.4e-05 23.5 0.7 0.0003 19.2 0.0 2.3 2 0 0 2 2 2 1 BT1 family DUF4834 PF16118.5 ETO28175.1 - 0.013 16.5 0.3 0.013 16.5 0.3 4.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4834) Vpu PF00558.19 ETO28175.1 - 5.1 6.9 6.5 16 5.4 6.5 1.8 1 0 0 1 1 1 0 Vpu protein B277 PF17623.2 ETO28177.1 - 2.2 7.3 8.2 4.5 6.3 8.2 1.5 1 0 0 1 1 1 0 Domain of unknown function zf-C2H2_4 PF13894.6 ETO28178.1 - 3.4e-06 27.4 32.8 0.00072 20.2 1.9 4.1 4 1 0 4 4 3 3 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETO28178.1 - 3.5e-06 27.1 20.3 0.0026 18.0 1.5 3.6 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 ETO28178.1 - 4.1e-05 23.8 14.0 0.00033 20.9 1.1 4.0 4 0 0 4 4 3 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO28178.1 - 6.4e-05 23.2 26.8 0.0059 17.0 3.6 5.0 4 1 0 5 5 4 2 Zinc-finger double domain zf-met PF12874.7 ETO28178.1 - 0.003 17.9 15.2 0.44 11.0 0.7 3.6 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2_8 PF15909.5 ETO28178.1 - 0.01 16.1 5.3 0.01 16.1 5.3 2.0 1 1 1 2 2 2 0 C2H2-type zinc ribbon DUF4825 PF16107.5 ETO28178.1 - 0.017 15.2 0.4 0.67 10.1 0.1 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4825) zf-C2H2_6 PF13912.6 ETO28178.1 - 0.018 15.0 1.2 0.018 15.0 1.2 3.9 4 0 0 4 4 4 0 C2H2-type zinc finger BolA PF01722.18 ETO28178.1 - 0.059 13.7 1.5 1.7 9.0 0.2 2.6 1 1 1 2 2 2 0 BolA-like protein Zf_RING PF16744.5 ETO28178.1 - 0.077 13.1 11.9 0.72 10.0 2.1 3.3 1 1 2 3 3 3 0 KIAA1045 RING finger zf_C2H2_ZHX PF18387.1 ETO28178.1 - 0.45 10.2 12.2 9.8 5.9 0.1 3.3 2 1 1 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 ETO28178.1 - 1.5 9.2 21.3 4 7.8 2.7 3.4 1 1 1 2 2 2 0 C2H2 type zinc-finger (2 copies) Pyr_redox_2 PF07992.14 ETO28179.1 - 8.3e-41 140.1 0.2 2.1e-40 138.8 0.2 1.7 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETO28179.1 - 8.4e-27 93.6 0.2 3.9e-26 91.5 0.0 2.1 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain DEP PF00610.21 ETO28179.1 - 1.6e-20 72.9 0.2 3.1e-20 72.0 0.2 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Pyr_redox PF00070.27 ETO28179.1 - 1.6e-05 25.4 1.1 0.0037 17.8 0.0 3.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase SGIII PF15467.6 ETO28179.1 - 0.12 11.6 5.0 0.18 11.0 5.0 1.2 1 0 0 1 1 1 0 Secretogranin-3 DUF2076 PF09849.9 ETO28180.1 - 2.6 8.0 11.9 2.8 7.9 11.9 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF5580 PF17743.1 ETO28180.1 - 8.3 4.8 10.8 8.9 4.7 10.8 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5580) LRR_4 PF12799.7 ETO28181.1 - 0.00026 21.3 1.9 0.00026 21.3 1.9 4.4 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO28181.1 - 0.00039 20.3 12.0 0.045 13.8 0.1 5.7 5 0 0 5 5 5 2 Leucine Rich repeat Mobilization_B PF17511.2 ETO28181.1 - 5 7.5 10.4 0.13 12.6 0.8 2.7 2 1 0 2 2 2 0 Mobilization protein B PPR PF01535.20 ETO28182.1 - 7.7e-08 32.1 12.3 1.1 9.7 0.0 8.7 10 0 0 10 10 10 3 PPR repeat DYW_deaminase PF14432.6 ETO28182.1 - 8.8e-08 32.1 6.1 1.1e-07 31.7 4.1 2.1 2 0 0 2 2 2 1 DYW family of nucleic acid deaminases PPR_2 PF13041.6 ETO28182.1 - 0.0001 22.4 18.9 0.14 12.4 0.0 7.7 9 0 0 9 9 9 2 PPR repeat family PPR_1 PF12854.7 ETO28182.1 - 0.01 15.6 2.7 2.4 8.0 0.0 4.3 5 0 0 5 5 5 1 PPR repeat AATF-Che1 PF13339.6 ETO28182.1 - 4.2 8.0 9.5 2 9.1 6.0 2.2 2 0 0 2 2 2 0 Apoptosis antagonizing transcription factor PPO1_KFDV PF12143.8 ETO28183.1 - 0.24 11.5 4.6 0.25 11.4 1.7 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF_B2219) Asp-B-Hydro_N PF05279.11 ETO28183.1 - 0.52 10.3 10.7 0.95 9.5 10.7 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Presenilin PF01080.17 ETO28183.1 - 8.6 5.0 9.3 14 4.3 9.3 1.5 1 0 0 1 1 1 0 Presenilin DUF445 PF04286.12 ETO28184.1 - 0.15 11.9 0.1 0.15 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) FYVE PF01363.21 ETO28184.1 - 0.34 11.1 4.4 1.2 9.3 0.9 2.3 2 0 0 2 2 2 0 FYVE zinc finger zf-C3HC4_4 PF15227.6 ETO28184.1 - 0.51 10.6 6.2 0.44 10.8 3.7 2.2 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-RING_4 PF14570.6 ETO28184.1 - 0.87 9.4 7.1 0.063 13.1 1.5 1.9 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain MBOAT PF03062.19 ETO28186.1 - 4.1e-23 82.3 27.9 7.7e-14 51.8 11.3 2.1 2 0 0 2 2 2 2 MBOAT, membrane-bound O-acyltransferase family MRI PF15325.6 ETO28186.1 - 1.1 10.4 6.2 0.46 11.6 3.8 1.6 2 0 0 2 2 2 0 Modulator of retrovirus infection MBOAT_2 PF13813.6 ETO28186.1 - 1.9 8.8 11.8 2.7e+02 1.9 11.8 2.6 1 1 0 1 1 1 0 Membrane bound O-acyl transferase family Apis_Csd PF11671.8 ETO28187.1 - 0.45 10.5 10.4 0.1 12.6 7.0 1.6 2 0 0 2 2 2 0 Complementary sex determiner protein ALMT PF11744.8 ETO28187.1 - 2.7 6.7 10.7 3.4 6.4 10.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4834 PF16118.5 ETO28187.1 - 3.8 8.5 7.2 1.8 9.6 0.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Pet20 PF08692.10 ETO28187.1 - 8.6 7.1 8.8 0.79 10.4 0.1 2.2 1 1 1 2 2 2 0 Mitochondrial protein Pet20 Uso1_p115_head PF04869.14 ETO28188.1 - 3.9e-06 26.2 0.2 4.2e-06 26.1 0.2 1.1 1 0 0 1 1 1 1 Uso1 / p115 like vesicle tethering protein, head region zf-RanBP PF00641.18 ETO28189.1 - 2.8e-06 26.5 3.2 6.7e-06 25.3 3.2 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO28189.1 - 0.0041 16.5 1.5 0.01 15.2 1.5 1.6 1 0 0 1 1 1 1 Vacuolar protein sorting 36 NZF-N zinc-finger domain zf-Sec23_Sec24 PF04810.15 ETO28189.1 - 0.067 13.3 0.3 0.3 11.2 0.3 2.2 1 0 0 1 1 1 0 Sec23/Sec24 zinc finger SH3_15 PF18346.1 ETO28189.1 - 0.072 13.4 0.0 0.27 11.6 0.0 1.9 1 1 0 1 1 1 0 Mind bomb SH3 repeat domain GlcNAc PF11397.8 ETO28190.1 - 2.4e-34 119.3 0.4 4.2e-34 118.6 0.4 1.4 1 1 0 1 1 1 1 Glycosyltransferase (GlcNAc) Glyco_trans_2_3 PF13632.6 ETO28190.1 - 0.0038 17.2 0.5 0.008 16.1 0.0 1.8 2 0 0 2 2 2 1 Glycosyl transferase family group 2 IRK PF01007.20 ETO28190.1 - 0.033 14.0 0.1 0.054 13.3 0.1 1.3 1 0 0 1 1 1 0 Inward rectifier potassium channel transmembrane domain GHL15 PF14885.6 ETO28192.1 - 0.011 15.7 1.8 0.014 15.4 1.8 1.1 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 Cobalamin_bind PF01122.19 ETO28192.1 - 0.016 14.2 4.8 0.025 13.5 4.8 1.4 1 1 0 1 1 1 0 Eukaryotic cobalamin-binding protein WTX PF09422.10 ETO28192.1 - 0.23 10.5 3.8 0.28 10.2 3.8 1.1 1 0 0 1 1 1 0 WTX protein Proton_antipo_C PF01010.19 ETO28192.1 - 2.5 7.7 12.5 1.3 8.6 10.2 1.8 1 1 1 2 2 2 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus Orf78 PF06024.12 ETO28194.1 - 0.12 12.7 0.1 0.59 10.5 0.0 2.1 2 0 0 2 2 2 0 Orf78 (ac78) UCH PF00443.29 ETO28195.1 - 3.1e-41 141.6 3.9 3.1e-41 141.6 3.9 3.0 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO28195.1 - 4.1e-29 102.2 5.5 4.1e-29 102.2 5.5 2.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase FAM92 PF06730.11 ETO28195.1 - 0.025 14.0 3.5 3 7.2 1.6 2.5 2 0 0 2 2 2 0 FAM92 protein TPR_11 PF13414.6 ETO28196.1 - 8.1e-17 60.6 28.3 9.8e-06 25.2 0.9 5.5 4 1 1 5 5 5 5 TPR repeat TPR_2 PF07719.17 ETO28196.1 - 7.1e-10 38.2 28.2 0.0096 16.0 0.1 7.5 6 2 1 7 7 7 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO28196.1 - 2.4e-08 33.8 23.8 0.00019 21.6 1.2 5.9 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO28196.1 - 6.8e-08 32.7 8.9 1.3 10.1 0.2 6.0 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28196.1 - 8.4e-06 25.4 34.6 0.0047 16.7 0.2 7.8 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28196.1 - 9.5e-06 25.4 15.1 2.6 8.5 0.7 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_19 PF14559.6 ETO28196.1 - 0.0014 19.1 17.7 0.13 12.8 0.8 5.8 4 2 2 6 6 6 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28196.1 - 0.0062 16.8 21.6 0.044 14.1 7.2 5.2 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO28196.1 - 0.0077 16.9 13.8 0.2 12.3 1.7 4.5 3 2 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO28196.1 - 0.18 12.0 3.9 0.56 10.4 0.1 3.0 3 1 1 4 4 4 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO28196.1 - 4.1 7.6 18.5 4.9 7.3 0.1 5.7 6 0 0 6 6 6 0 Fis1 C-terminal tetratricopeptide repeat La PF05383.17 ETO28197.1 - 9.8e-15 54.4 0.0 2e-14 53.3 0.0 1.5 1 0 0 1 1 1 1 La domain EF-hand_6 PF13405.6 ETO28198.1 - 0.021 14.7 0.0 0.085 12.8 0.0 2.1 1 0 0 1 1 1 0 EF-hand domain Speriolin_C PF15059.6 ETO28198.1 - 0.042 14.0 5.4 0.036 14.2 1.6 2.7 2 0 0 2 2 2 0 Speriolin C-terminus SAWADEE PF16719.5 ETO28198.1 - 0.05 13.6 0.3 0.05 13.6 0.3 2.4 2 0 0 2 2 2 0 SAWADEE domain DUF1104 PF06518.11 ETO28198.1 - 0.36 11.2 0.0 0.36 11.2 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1104) EF-hand_7 PF13499.6 ETO28198.1 - 0.67 10.4 0.0 0.67 10.4 0.0 3.5 5 0 0 5 5 5 0 EF-hand domain pair CPG4 PF15481.6 ETO28198.1 - 2 9.1 7.0 37 5.0 1.3 3.9 3 0 0 3 3 3 0 Chondroitin proteoglycan 4 DUF2439 PF10382.9 ETO28199.1 - 0.00043 20.6 0.3 0.0011 19.3 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2439) PDEase_I PF00233.19 ETO28200.1 - 6.4e-67 225.8 0.0 6.4e-67 225.8 0.0 2.7 1 1 2 3 3 3 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETO28200.1 - 0.0091 16.2 0.0 0.026 14.7 0.0 1.8 1 0 0 1 1 1 1 HD domain HrpA_pilin PF09589.10 ETO28200.1 - 0.027 15.1 3.6 0.056 14.1 1.5 2.5 3 0 0 3 3 3 0 HrpA pilus formation protein PI_PP_I PF18363.1 ETO28201.1 - 0.071 13.3 0.1 2.8 8.2 0.0 2.4 2 0 0 2 2 2 0 Phosphoinositide phosphatase insertion domain GP120 PF00516.18 ETO28202.1 - 0.035 12.7 0.0 0.055 12.1 0.0 1.2 1 0 0 1 1 1 0 Envelope glycoprotein GP120 Sigma70_ner PF04546.13 ETO28202.1 - 0.048 13.5 4.9 0.37 10.6 3.5 2.1 2 0 0 2 2 2 0 Sigma-70, non-essential region IN_DBD_C PF00552.21 ETO28203.1 - 0.023 14.0 0.0 0.042 13.2 0.0 1.4 1 0 0 1 1 1 0 Integrase DNA binding domain PRIMA1 PF16101.5 ETO28204.1 - 0.072 13.1 2.8 1.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 AIM3 PF17096.5 ETO28204.1 - 3.4 8.7 20.3 8.3 7.4 3.9 3.6 2 1 1 3 3 3 0 Altered inheritance of mitochondria protein 3 NESP55 PF06390.12 ETO28205.1 - 0.0012 18.5 1.1 0.002 17.8 1.1 1.4 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) DnaJ_C PF01556.18 ETO28205.1 - 0.03 14.4 2.0 0.036 14.2 2.0 1.3 1 0 0 1 1 1 0 DnaJ C terminal domain Bactofilin PF04519.13 ETO28205.1 - 0.066 13.5 5.5 0.1 12.9 4.7 1.7 2 0 0 2 2 2 0 Polymer-forming cytoskeletal DUF481 PF04338.12 ETO28205.1 - 0.13 12.2 0.2 0.18 11.8 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF481 Glyco_hydro_2 PF00703.21 ETO28205.1 - 0.26 12.0 7.7 0.47 11.2 6.9 1.8 1 1 1 2 2 2 0 Glycosyl hydrolases family 2 DUF2271 PF10029.9 ETO28205.1 - 0.35 10.5 5.1 0.59 9.8 4.3 1.8 1 1 0 1 1 1 0 Predicted periplasmic protein (DUF2271) BMF PF15185.6 ETO28205.1 - 0.38 10.4 4.3 0.62 9.8 4.3 1.4 1 1 0 1 1 1 0 Bcl-2-modifying factor, apoptosis DUF5390 PF17365.2 ETO28205.1 - 0.46 10.8 4.3 1.4 9.2 0.5 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5390) Glyco_hydro_38C PF07748.13 ETO28205.1 - 0.66 10.0 6.4 0.34 11.0 4.4 1.5 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal domain Kinesin PF00225.23 ETO28206.1 - 2.9e-52 177.6 0.0 2.9e-52 177.6 0.0 2.5 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ETO28206.1 - 3.4e-39 134.2 0.3 3.4e-39 134.2 0.3 3.0 3 0 0 3 3 3 1 Microtubule binding Cob_adeno_trans PF01923.18 ETO28206.1 - 5.1 7.2 7.6 1.3 9.2 0.8 2.7 1 1 1 2 2 2 0 Cobalamin adenosyltransferase CENP-F_leu_zip PF10473.9 ETO28206.1 - 5.7 7.0 34.4 0.68 9.9 12.3 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 HrpB7 PF09486.10 ETO28206.1 - 7.9 6.9 16.5 0.48 10.8 11.1 1.8 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DNA_pol_A_exo1 PF01612.20 ETO28207.1 - 0.019 14.7 0.1 0.038 13.7 0.0 1.5 2 0 0 2 2 2 0 3'-5' exonuclease DNA_pol_A_exo1 PF01612.20 ETO28208.1 - 1.7e-12 47.4 0.0 5.2e-12 45.8 0.0 1.7 1 1 0 1 1 1 1 3'-5' exonuclease DEP PF00610.21 ETO28209.1 - 1.4e-14 53.9 0.0 4.5e-14 52.3 0.0 1.9 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PTEN_C2 PF10409.9 ETO28209.1 - 1.3e-09 37.9 4.1 1.6e-09 37.6 1.9 2.3 1 1 1 2 2 2 1 C2 domain of PTEN tumour-suppressor protein DSPc PF00782.20 ETO28209.1 - 0.00033 20.5 0.1 0.00033 20.5 0.1 2.4 3 0 0 3 3 3 1 Dual specificity phosphatase, catalytic domain PTPlike_phytase PF14566.6 ETO28209.1 - 0.00036 20.7 0.0 0.0014 18.8 0.0 2.1 1 1 0 1 1 1 1 Inositol hexakisphosphate ATP_synt_H PF05493.13 ETO28209.1 - 0.023 15.2 0.5 0.069 13.6 0.0 2.1 2 0 0 2 2 2 0 ATP synthase subunit H Y_phosphatase3 PF13350.6 ETO28209.1 - 0.066 13.2 1.7 0.074 13.0 0.5 1.6 2 0 0 2 2 2 0 Tyrosine phosphatase family LEAP-2 PF07359.11 ETO28209.1 - 0.077 12.8 0.5 1.1 9.1 0.3 2.7 2 1 1 3 3 3 0 Liver-expressed antimicrobial peptide 2 precursor (LEAP-2) VIT1 PF01988.19 ETO28210.1 - 7.3e-44 150.2 3.0 8.7e-44 150.0 0.0 1.9 2 0 0 2 2 2 1 VIT family DUF3784 PF12650.7 ETO28210.1 - 0.057 13.6 0.4 0.15 12.3 0.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3784) tRNA-synt_2b PF00587.25 ETO28211.1 - 6.8e-36 123.9 0.2 1.9e-27 96.4 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetase class II core domain (G, H, P, S and T) HGTP_anticodon PF03129.20 ETO28211.1 - 8.7e-20 70.7 0.1 1.5e-13 50.7 0.0 2.2 2 0 0 2 2 2 2 Anticodon binding domain YvrJ PF12841.7 ETO28212.1 - 2.1 7.9 7.1 6.3 6.4 0.2 2.6 2 1 0 2 2 2 0 YvrJ protein family G-alpha PF00503.20 ETO28213.1 - 4.8e-09 35.9 1.3 9.3e-09 34.9 0.1 2.0 2 1 0 2 2 2 1 G-protein alpha subunit Rad17 PF03215.15 ETO28213.1 - 0.0007 19.6 0.0 0.001 19.0 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain ABC_tran PF00005.27 ETO28213.1 - 0.0018 18.8 0.0 0.0037 17.8 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ETO28213.1 - 0.0048 17.3 0.0 0.007 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO28213.1 - 0.0073 16.7 0.0 0.022 15.1 0.0 1.9 1 0 0 1 1 1 1 RNA helicase NB-ARC PF00931.22 ETO28213.1 - 0.013 14.7 0.0 0.019 14.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain RsgA_GTPase PF03193.16 ETO28213.1 - 0.013 15.4 0.6 0.032 14.1 0.5 1.8 1 1 1 2 2 2 0 RsgA GTPase ATPase_2 PF01637.18 ETO28213.1 - 0.02 14.8 0.2 0.066 13.1 0.0 1.9 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea AAA_22 PF13401.6 ETO28213.1 - 0.021 15.1 0.1 0.05 13.9 0.0 1.7 1 1 1 2 2 2 0 AAA domain PduV-EutP PF10662.9 ETO28213.1 - 0.035 13.8 0.0 0.073 12.8 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA PF00004.29 ETO28213.1 - 0.043 14.2 0.1 0.2 12.1 0.0 2.2 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ETO28213.1 - 0.064 13.0 0.1 0.24 11.2 0.1 1.9 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO28213.1 - 0.072 13.6 3.8 0.24 11.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain AAA_5 PF07728.14 ETO28213.1 - 0.13 12.3 0.0 0.29 11.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Mg_chelatase PF01078.21 ETO28213.1 - 0.13 11.6 0.6 0.23 10.8 0.0 1.7 2 1 0 2 2 2 0 Magnesium chelatase, subunit ChlI Apyrase PF06079.11 ETO28214.1 - 2.2e-70 237.2 9.2 8e-53 179.5 1.8 5.4 2 2 2 4 4 4 4 Apyrase HA2 PF04408.23 ETO28214.1 - 2.1 8.7 4.0 7.8 6.8 0.2 3.0 3 0 0 3 3 3 0 Helicase associated domain (HA2) DUF373 PF04123.13 ETO28215.1 - 1.8 7.9 13.1 2.1 7.7 12.3 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF373) Vma12 PF11712.8 ETO28215.1 - 8.2 6.5 15.8 2 8.5 2.8 3.2 2 1 1 3 3 3 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Caldesmon PF02029.15 ETO28216.1 - 0.72 8.5 33.4 0.86 8.3 33.4 1.1 1 0 0 1 1 1 0 Caldesmon SOG2 PF10428.9 ETO28216.1 - 3.7 6.6 21.7 4 6.5 21.7 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF724 PF05266.14 ETO28217.1 - 1.5 8.6 22.2 0.48 10.2 3.4 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF724) TMPIT PF07851.13 ETO28217.1 - 8 5.6 14.3 1.9 7.7 4.5 2.2 2 0 0 2 2 2 0 TMPIT-like protein MS_channel PF00924.18 ETO28219.1 - 2.9e-09 36.8 4.1 2.9e-09 36.8 4.1 1.8 2 0 0 2 2 2 1 Mechanosensitive ion channel E1-E2_ATPase PF00122.20 ETO28219.1 - 0.099 12.2 0.3 0.18 11.3 0.3 1.3 1 0 0 1 1 1 0 E1-E2 ATPase Putative_PNPOx PF01243.20 ETO28220.1 - 1.1e-06 28.7 0.0 3.6e-06 27.1 0.0 1.9 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase PNP_phzG_C PF10590.9 ETO28220.1 - 3.9e-06 26.8 1.6 7.5e-06 25.9 1.6 1.4 1 0 0 1 1 1 1 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region Pyrid_ox_like PF16242.5 ETO28220.1 - 0.00053 19.6 0.4 0.0023 17.5 0.0 2.0 2 0 0 2 2 2 1 Pyridoxamine 5'-phosphate oxidase like Pyridox_oxase_2 PF12766.7 ETO28220.1 - 0.0008 20.0 0.0 0.0023 18.5 0.0 1.7 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase Pyrid_oxidase_2 PF13883.6 ETO28220.1 - 0.0029 17.6 0.0 0.011 15.7 0.0 1.9 1 0 0 1 1 1 1 Pyridoxamine 5'-phosphate oxidase HEAT PF02985.22 ETO28221.1 - 0.00056 19.9 10.5 0.038 14.2 0.1 4.5 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ETO28221.1 - 0.0014 18.9 0.0 2.4 8.6 0.0 3.3 2 1 1 3 3 3 2 HEAT repeats Vac14_Fab1_bd PF12755.7 ETO28221.1 - 0.0082 16.7 4.4 1.2 9.7 0.1 3.3 3 0 0 3 3 3 2 Vacuolar 14 Fab1-binding region DUF3461 PF11944.8 ETO28221.1 - 0.0095 16.1 0.8 3 8.0 0.1 2.9 2 0 0 2 2 2 2 Protein of unknown function (DUF3461) HEAT_EZ PF13513.6 ETO28221.1 - 0.074 13.6 0.1 3.3 8.3 0.0 3.1 2 1 1 3 3 3 0 HEAT-like repeat UME PF08064.13 ETO28221.1 - 4.5 7.2 6.4 7 6.6 0.2 3.4 3 1 1 4 4 4 0 UME (NUC010) domain Calreticulin PF00262.18 ETO28222.1 - 2.1e-68 230.8 44.7 7.7e-38 130.3 0.0 4.8 4 1 1 5 5 5 3 Calreticulin family Microtub_bd PF16796.5 ETO28222.1 - 0.00096 19.1 5.7 0.0029 17.6 5.7 1.8 1 1 0 1 1 1 1 Microtubule binding Kinesin PF00225.23 ETO28222.1 - 0.0046 15.9 10.8 0.022 13.7 10.6 2.0 1 1 0 1 1 1 1 Kinesin motor domain ShlB PF03865.13 ETO28222.1 - 0.2 11.1 2.7 0.24 10.8 0.1 2.2 3 0 0 3 3 3 0 Haemolysin secretion/activation protein ShlB/FhaC/HecB B2-adapt-app_C PF09066.10 ETO28223.1 - 2.6e-13 50.0 2.0 2.6e-13 50.0 2.0 2.9 2 0 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain B277 PF17623.2 ETO28223.1 - 0.2 10.7 7.2 0.74 8.8 7.2 1.9 1 0 0 1 1 1 0 Domain of unknown function Cation_efflux PF01545.21 ETO28225.1 - 3.4e-05 23.6 4.3 4.5e-05 23.3 4.3 1.1 1 0 0 1 1 1 1 Cation efflux family DUF1673 PF07895.11 ETO28225.1 - 0.015 15.0 0.3 0.022 14.5 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1673) Cation_efflux PF01545.21 ETO28226.1 - 6.3e-08 32.6 3.4 8.1e-08 32.2 3.4 1.1 1 0 0 1 1 1 1 Cation efflux family ZT_dimer PF16916.5 ETO28226.1 - 1.4e-07 31.5 4.9 2.3e-07 30.9 4.9 1.3 1 0 0 1 1 1 1 Dimerisation domain of Zinc Transporter DUF5461 PF17545.2 ETO28226.1 - 0.026 14.8 0.2 0.058 13.7 0.2 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5461) RasGEF PF00617.19 ETO28227.1 - 2.5e-16 60.4 4.6 5.1e-09 36.6 0.1 3.4 3 1 1 4 4 4 2 RasGEF domain Pkinase PF00069.25 ETO28229.1 - 1.9e-32 112.7 0.0 2.4e-32 112.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28229.1 - 4.1e-12 45.9 0.0 4.6e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO28229.1 - 2.9e-05 23.1 0.0 3.9e-05 22.6 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ETO28229.1 - 0.0022 17.7 0.1 0.0036 17.0 0.1 1.3 1 0 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Kinase-like PF14531.6 ETO28229.1 - 0.015 14.7 0.1 1.7 7.9 0.0 2.1 2 0 0 2 2 2 0 Kinase-like APH PF01636.23 ETO28229.1 - 0.028 14.3 0.0 0.04 13.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ETO28229.1 - 0.076 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WD40 PF00400.32 ETO28230.1 - 7.3e-28 96.3 14.9 6.8e-06 26.7 0.2 6.0 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28230.1 - 4.7e-09 36.4 0.2 0.024 15.0 0.0 3.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO28230.1 - 2.6e-06 26.4 6.2 0.35 9.5 1.3 4.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Zip PF02535.22 ETO28230.1 - 0.04 13.1 1.7 0.041 13.1 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO28230.1 - 0.88 8.3 12.1 1.1 7.9 12.1 1.2 1 0 0 1 1 1 0 Presenilin HARP PF07443.13 ETO28230.1 - 1.1 8.9 6.6 3.9 7.2 0.1 4.0 5 0 0 5 5 5 0 HepA-related protein (HARP) Dapper PF15268.6 ETO28230.1 - 7.2 5.3 15.9 8.7 5.1 15.9 1.1 1 0 0 1 1 1 0 Dapper Dynamitin PF04912.14 ETO28231.1 - 6.8e-13 48.7 1.8 8.7e-13 48.4 1.8 1.2 1 0 0 1 1 1 1 Dynamitin DUF1664 PF07889.12 ETO28231.1 - 0.051 13.6 0.5 8.1 6.5 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Dict-STAT-coil PF09267.10 ETO28231.1 - 0.14 12.5 4.0 0.075 13.4 1.6 1.7 2 0 0 2 2 2 0 Dictyostelium STAT, coiled coil BRCC36_C PF18110.1 ETO28231.1 - 0.39 10.9 3.5 0.67 10.2 3.5 1.7 1 1 0 1 1 1 0 BRCC36 C-terminal helical domain Fib_alpha PF08702.10 ETO28231.1 - 0.55 10.4 6.1 0.43 10.8 0.6 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Thymosin PF01290.20 ETO28232.1 - 0.0089 15.7 0.2 0.033 13.9 0.2 2.0 1 0 0 1 1 1 1 Thymosin beta-4 family DUF4199 PF13858.6 ETO28235.1 - 0.25 11.7 11.1 0.1 13.0 7.7 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF4199) Stevor PF17410.2 ETO28235.1 - 0.32 10.5 1.3 0.62 9.6 1.3 1.4 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame ALS2CR8 PF15299.6 ETO28237.1 - 0.18 11.6 6.7 0.3 10.9 6.6 1.4 1 1 0 1 1 1 0 Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 DUF1664 PF07889.12 ETO28237.1 - 1 9.4 10.4 0.51 10.4 6.5 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) bZIP_1 PF00170.21 ETO28238.1 - 0.0011 19.0 4.2 0.0011 19.0 4.2 2.0 2 0 0 2 2 2 1 bZIP transcription factor DUF3439 PF11921.8 ETO28239.1 - 0.011 15.7 7.0 0.025 14.5 7.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) FTH PF01827.27 ETO28239.1 - 0.27 11.0 6.6 0.088 12.6 2.4 2.2 2 0 0 2 2 2 0 FTH domain Spt20 PF12090.8 ETO28240.1 - 0.0055 16.4 4.6 0.0055 16.4 4.6 1.5 2 0 0 2 2 2 1 Spt20 family TssN PF17555.2 ETO28240.1 - 0.0093 15.4 1.9 0.015 14.7 1.9 1.3 1 0 0 1 1 1 1 Type VI secretion system, TssN DUF3433 PF11915.8 ETO28240.1 - 0.1 13.0 0.1 0.32 11.5 0.1 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF3433) Apis_Csd PF11671.8 ETO28240.1 - 0.22 11.5 5.6 0.46 10.5 5.6 1.6 1 0 0 1 1 1 0 Complementary sex determiner protein Orf78 PF06024.12 ETO28240.1 - 5.6 7.3 6.7 16 5.9 6.7 1.8 1 1 0 1 1 1 0 Orf78 (ac78) Lipase_GDSL_2 PF13472.6 ETO28241.1 - 1.6e-05 25.4 0.0 3.1e-05 24.5 0.0 1.4 2 0 0 2 2 2 1 GDSL-like Lipase/Acylhydrolase family RTC PF01137.21 ETO28242.1 - 2.8e-47 160.8 0.0 2.9e-46 157.5 0.0 1.9 1 1 0 1 1 1 1 RNA 3'-terminal phosphate cyclase RTC_insert PF05189.13 ETO28242.1 - 1.5e-20 73.6 0.0 2.9e-20 72.7 0.0 1.5 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase (RTC), insert domain MutL_C PF08676.11 ETO28243.1 - 1.5e-12 47.5 3.1 1.5e-08 34.6 1.1 3.5 2 1 0 2 2 2 2 MutL C terminal dimerisation domain ORC6 PF05460.13 ETO28243.1 - 1.4 8.1 12.8 4.9 6.3 12.7 1.8 1 1 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) Glyco_hydro_38N PF01074.22 ETO28244.1 - 1.1e-14 54.5 3.8 2.4e-14 53.4 3.8 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain Egg_lysin PF01303.17 ETO28244.1 - 0.088 13.0 0.1 0.12 12.6 0.1 1.1 1 0 0 1 1 1 0 Egg lysin (Sperm-lysin) B56 PF01603.20 ETO28245.1 - 3.1e-86 289.9 4.8 3.1e-86 289.9 4.8 2.8 3 0 0 3 3 3 1 Protein phosphatase 2A regulatory B subunit (B56 family) Nop14 PF04147.12 ETO28245.1 - 0.91 7.7 85.4 0.032 12.5 39.9 2.5 2 0 0 2 2 2 0 Nop14-like family DUF3365 PF11845.8 ETO28246.1 - 0.07 13.4 0.3 3.2 8.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) PAS_9 PF13426.7 ETO28246.1 - 0.086 13.1 0.1 0.15 12.3 0.1 1.3 1 0 0 1 1 1 0 PAS domain SPX PF03105.19 ETO28247.1 - 0.0085 16.1 4.5 0.0085 16.1 4.5 2.3 1 1 1 2 2 2 1 SPX domain Exo_endo_phos PF03372.23 ETO28248.1 - 0.003 17.1 0.0 0.016 14.8 0.0 2.1 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MOR2-PAG1_C PF14225.6 ETO28249.1 - 4e-09 36.7 0.0 6.4e-09 36.0 0.0 1.3 1 0 0 1 1 1 1 Cell morphogenesis C-terminal Preseq_ALAS PF09029.10 ETO28249.1 - 0.026 15.0 0.0 0.063 13.8 0.0 1.6 1 0 0 1 1 1 0 5-aminolevulinate synthase presequence Peptidase_C57 PF03290.13 ETO28249.1 - 0.038 12.7 0.0 0.1 11.3 0.0 1.6 2 0 0 2 2 2 0 Vaccinia virus I7 processing peptidase AAA_31 PF13614.6 ETO28250.1 - 5.3e-08 33.0 0.0 8.2e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 AAA domain VirC1 PF07015.11 ETO28250.1 - 0.18 11.1 0.0 0.23 10.7 0.0 1.2 1 0 0 1 1 1 0 VirC1 protein DnaJ PF00226.31 ETO28251.1 - 1.6e-26 92.2 0.8 3.1e-26 91.3 0.8 1.5 1 0 0 1 1 1 1 DnaJ domain RT_RNaseH_2 PF17919.1 ETO28252.1 - 5.9e-16 58.3 2.0 9.2e-15 54.5 0.1 3.0 3 1 0 3 3 3 1 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETO28252.1 - 1.5e-05 25.2 0.4 7.7e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 RNase H-like domain found in reverse transcriptase dCache_2 PF08269.11 ETO28252.1 - 0.16 11.1 9.8 0.047 12.9 6.7 1.7 2 0 0 2 2 2 0 Cache domain G-alpha PF00503.20 ETO28253.1 - 4.3e-19 68.9 8.9 1.5e-18 67.1 8.9 1.7 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO28253.1 - 0.0091 15.5 2.2 1 8.8 0.6 2.3 1 1 1 2 2 2 2 ADP-ribosylation factor family RNaseH_C PF09293.10 ETO28253.1 - 0.25 11.7 3.5 0.18 12.1 0.8 2.1 2 1 0 2 2 2 0 T4 RNase H, C terminal His_Phos_1 PF00300.22 ETO28254.1 - 2.7e-07 30.5 0.1 8.1e-06 25.7 0.0 2.1 1 1 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) Lact_bio_phlase PF09508.10 ETO28254.1 - 0.015 13.7 0.1 0.021 13.3 0.1 1.1 1 0 0 1 1 1 0 Lacto-N-biose phosphorylase N-terminal TIM barrel domain FANCM-MHF_bd PF16783.5 ETO28254.1 - 0.12 12.5 0.8 0.25 11.4 0.4 1.7 2 0 0 2 2 2 0 FANCM to MHF binding domain PDT PF00800.18 ETO28255.1 - 0.056 13.3 1.7 0.29 10.9 1.7 1.8 1 1 0 1 1 1 0 Prephenate dehydratase Endonuc-FokI_C PF09254.11 ETO28255.1 - 0.11 11.7 0.2 0.17 11.1 0.2 1.3 1 0 0 1 1 1 0 Restriction endonuclease FokI, C terminal PHD PF00628.29 ETO28256.1 - 1.6e-08 34.3 7.1 1.6e-08 34.3 7.1 3.6 2 1 1 3 3 3 1 PHD-finger zf-rbx1 PF12678.7 ETO28256.1 - 3.3e-06 27.3 2.3 3.3e-06 27.3 2.3 3.6 4 0 0 4 4 4 1 RING-H2 zinc finger domain zf-RING_2 PF13639.6 ETO28256.1 - 7.7e-06 26.2 2.2 7.7e-06 26.2 2.2 4.3 3 1 0 3 3 3 1 Ring finger domain Hid1 PF12722.7 ETO28256.1 - 0.0016 16.7 3.4 0.0021 16.3 3.4 1.1 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein PHD_2 PF13831.6 ETO28256.1 - 0.0025 17.3 0.8 0.0025 17.3 0.8 2.9 3 0 0 3 3 3 1 PHD-finger zf-C3HC4_2 PF13923.6 ETO28256.1 - 0.005 16.7 1.7 0.005 16.7 1.7 3.8 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO28256.1 - 0.041 13.9 8.8 0.064 13.3 1.2 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_4 PF15227.6 ETO28256.1 - 1.3 9.2 6.6 13 6.0 1.0 3.5 2 0 0 2 2 2 0 zinc finger of C3HC4-type, RING zf-C2H2_6 PF13912.6 ETO28256.1 - 1.9 8.6 8.3 1.5 8.9 0.2 3.1 3 0 0 3 3 3 0 C2H2-type zinc finger RINGv PF12906.7 ETO28256.1 - 4.6 7.5 12.7 0.18 12.0 2.6 3.0 2 0 0 2 2 2 0 RING-variant domain Zn_ribbon_17 PF17120.5 ETO28256.1 - 4.9 6.8 11.6 0.51 10.0 3.6 2.7 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Rad51 PF08423.11 ETO28257.1 - 1.2e-07 31.3 0.0 1.6e-07 30.8 0.0 1.3 1 0 0 1 1 1 1 Rad51 ATPase PF06745.13 ETO28257.1 - 0.0001 21.8 0.0 0.00025 20.5 0.0 1.6 1 0 0 1 1 1 1 KaiC AAA_14 PF13173.6 ETO28257.1 - 0.79 9.8 4.1 0.33 11.0 0.2 2.4 2 2 1 3 3 3 0 AAA domain ADH_zinc_N PF00107.26 ETO28258.1 - 1.8e-24 86.2 0.1 4.4e-24 84.9 0.1 1.7 1 0 0 1 1 1 1 Zinc-binding dehydrogenase Esterase PF00756.20 ETO28258.1 - 3.5e-22 79.3 0.0 7.2e-22 78.2 0.0 1.4 1 1 0 1 1 1 1 Putative esterase ADH_N PF08240.12 ETO28258.1 - 5.1e-18 65.0 0.3 1.1e-17 63.8 0.3 1.6 1 0 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain Hydrolase_4 PF12146.8 ETO28258.1 - 0.005 16.1 0.0 0.0099 15.2 0.0 1.4 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Glu_dehyd_C PF16912.5 ETO28258.1 - 0.007 15.9 0.0 0.061 12.8 0.0 2.1 1 1 0 1 1 1 1 Glucose dehydrogenase C-terminus ADH_zinc_N_2 PF13602.6 ETO28258.1 - 0.0084 17.2 0.0 0.03 15.4 0.0 2.0 1 0 0 1 1 1 1 Zinc-binding dehydrogenase 2-Hacid_dh_C PF02826.19 ETO28258.1 - 0.067 12.5 0.2 0.12 11.7 0.2 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain XPG_I PF00867.18 ETO28260.1 - 2.1e-15 56.9 0.0 3.5e-15 56.1 0.0 1.4 1 0 0 1 1 1 1 XPG I-region XPG_I_2 PF12813.7 ETO28260.1 - 5.2e-08 32.7 0.0 5.2e-08 32.7 0.0 1.1 1 0 0 1 1 1 1 XPG domain containing Herpes_UL33 PF03581.13 ETO28260.1 - 0.013 15.9 0.1 3.8 7.9 0.0 2.1 2 0 0 2 2 2 0 Herpesvirus UL33-like protein CCDC74_C PF14917.6 ETO28261.1 - 5.9 7.4 10.2 0.17 12.4 1.4 2.7 3 1 0 3 3 3 0 Coiled coil protein 74, C terminal Radial_spoke PF04712.12 ETO28262.1 - 0.013 14.5 6.1 0.014 14.4 6.1 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein Sporozoite_P67 PF05642.11 ETO28262.1 - 0.014 13.5 14.9 0.016 13.3 14.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen YL1 PF05764.13 ETO28262.1 - 0.018 15.2 13.2 0.022 14.9 13.2 1.1 1 0 0 1 1 1 0 YL1 nuclear protein Nop14 PF04147.12 ETO28262.1 - 0.018 13.3 19.4 0.022 13.0 19.4 1.1 1 0 0 1 1 1 0 Nop14-like family Raftlin PF15250.6 ETO28262.1 - 0.029 13.1 4.9 0.033 13.0 4.9 1.0 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 ETO28262.1 - 0.057 11.6 6.6 0.057 11.5 6.6 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Rgp1 PF08737.10 ETO28262.1 - 0.16 11.1 9.3 0.19 10.9 9.3 1.1 1 0 0 1 1 1 0 Rgp1 CDC45 PF02724.14 ETO28262.1 - 0.17 10.2 15.9 0.2 9.9 15.9 1.0 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO28262.1 - 0.24 10.7 25.9 0.31 10.3 25.9 1.0 1 0 0 1 1 1 0 BUD22 O-antigen_lig PF13425.6 ETO28262.1 - 0.48 9.2 1.0 0.56 8.9 1.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FAM163 PF15069.6 ETO28262.1 - 0.74 10.2 8.2 1.2 9.6 8.2 1.3 1 0 0 1 1 1 0 FAM163 family Presenilin PF01080.17 ETO28262.1 - 0.89 8.2 15.4 1.3 7.8 15.4 1.2 1 0 0 1 1 1 0 Presenilin Rrn6 PF10214.9 ETO28262.1 - 1.3 7.4 16.5 1.7 7.0 16.5 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor SAPS PF04499.15 ETO28262.1 - 1.3 7.7 10.7 1.5 7.5 10.7 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Apt1 PF10351.9 ETO28262.1 - 2 7.1 14.8 2.5 6.9 14.8 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain Lin-8 PF03353.15 ETO28262.1 - 2.5 7.6 13.3 3 7.3 13.3 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SDA1 PF05285.12 ETO28262.1 - 2.9 7.2 22.6 3.8 6.8 22.6 1.1 1 0 0 1 1 1 0 SDA1 ALMT PF11744.8 ETO28262.1 - 4 6.2 6.2 4.4 6.0 6.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter PI3K_1B_p101 PF10486.9 ETO28262.1 - 6 4.5 13.2 8 4.1 13.2 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit TraV PF09676.10 ETO28262.1 - 6.4 7.8 11.3 8.9 7.3 11.3 1.2 1 0 0 1 1 1 0 Type IV conjugative transfer system lipoprotein (TraV) YfhD PF14151.6 ETO28265.1 - 1.4 9.1 7.3 0.24 11.6 1.4 2.5 1 1 2 3 3 3 0 YfhD-like protein eIF-3c_N PF05470.12 ETO28265.1 - 3.8 5.7 10.6 4.3 5.5 10.6 1.0 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus WD40 PF00400.32 ETO28266.1 - 3.9e-48 160.4 12.4 1.5e-09 38.3 0.1 7.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28266.1 - 3.3e-18 65.8 0.1 0.00088 19.5 0.0 7.4 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28266.1 - 3.1e-17 62.5 2.3 0.011 14.7 0.0 6.6 2 2 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO28266.1 - 1.6e-07 31.4 2.4 0.014 15.7 0.1 4.1 3 0 0 3 3 3 2 Kelch motif PD40 PF07676.12 ETO28266.1 - 3.6e-07 29.9 2.5 2.9 8.0 0.0 6.2 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Kelch_1 PF01344.25 ETO28266.1 - 1.4e-06 27.7 3.1 0.0025 17.3 0.6 3.4 3 0 0 3 3 3 2 Kelch motif WD40_like PF17005.5 ETO28266.1 - 1.2e-05 24.8 3.2 0.095 12.0 0.0 5.0 3 1 4 7 7 7 3 WD40-like domain Nbas_N PF15492.6 ETO28266.1 - 0.00032 20.1 2.2 11 5.2 0.0 5.5 2 1 4 6 6 6 1 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO28266.1 - 0.0018 17.0 1.1 1.4 7.4 0.0 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Kelch_2 PF07646.15 ETO28266.1 - 0.0039 17.1 1.6 2.5 8.2 0.4 4.0 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO28266.1 - 0.0052 16.8 0.6 0.59 10.2 0.2 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO28266.1 - 0.04 14.2 0.6 0.85 10.0 0.1 3.3 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO28266.1 - 0.048 13.7 6.5 0.37 10.8 1.5 3.3 3 0 0 3 3 3 0 Kelch motif DUF5570 PF17731.1 ETO28266.1 - 0.048 13.8 2.7 2.1 8.4 0.3 3.7 1 1 2 4 4 4 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO28266.1 - 0.15 11.8 8.1 22 4.8 0.0 5.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Sulfatase PF00884.23 ETO28267.1 - 5.1e-55 187.0 1.4 5.1e-55 187.0 1.4 1.8 2 0 0 2 2 2 1 Sulfatase Phosphodiest PF01663.22 ETO28267.1 - 1.8e-06 27.8 2.5 4.2e-05 23.3 1.4 2.8 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 ETO28267.1 - 0.0022 18.7 1.8 0.0041 17.8 0.4 2.2 2 1 0 2 2 2 1 C-terminal region of aryl-sulfatase DUF1501 PF07394.12 ETO28267.1 - 0.0067 15.5 0.0 0.011 14.8 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1501) LUC7 PF03194.15 ETO28267.1 - 0.0094 15.6 0.1 0.02 14.6 0.1 1.4 1 0 0 1 1 1 1 LUC7 N_terminus P_proprotein PF01483.20 ETO28267.1 - 0.074 13.1 0.2 9.8 6.3 0.1 2.5 2 0 0 2 2 2 0 Proprotein convertase P-domain rve_3 PF13683.6 ETO28267.1 - 0.17 11.7 0.8 3.1 7.6 0.3 2.9 3 0 0 3 3 3 0 Integrase core domain CDC45 PF02724.14 ETO28268.1 - 1.3 7.2 30.2 16 3.6 0.0 2.6 3 0 0 3 3 3 0 CDC45-like protein DUF2052 PF09747.9 ETO28268.1 - 7.5 6.6 25.4 2.4 8.2 22.2 1.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) ALMT PF11744.8 ETO28268.1 - 8.4 5.1 16.2 12 4.6 16.2 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter WD40 PF00400.32 ETO28269.1 - 5.9e-05 23.7 7.7 0.00066 20.4 0.1 3.8 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF2947 PF11163.8 ETO28269.1 - 0.16 11.8 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) Circo_capsid PF02443.15 ETO28269.1 - 0.38 10.3 14.5 0.52 9.9 14.5 1.2 1 0 0 1 1 1 0 Circovirus capsid protein PolyA_pol_RNAbd PF12627.7 ETO28270.1 - 6.2e-06 25.9 0.5 9.5e-05 22.1 0.0 2.8 3 0 0 3 3 3 1 Probable RNA and SrmB- binding site of polymerase A YkuI_C PF10388.9 ETO28270.1 - 1.5 8.6 8.9 0.35 10.7 0.4 2.9 3 0 0 3 3 3 0 EAL-domain associated signalling protein domain SelK_SelG PF10961.8 ETO28271.1 - 0.01 16.4 2.5 0.01 16.4 2.5 2.7 3 0 0 3 3 3 0 Selenoprotein SelK_SelG NACHT PF05729.12 ETO28274.1 - 4.4e-10 39.7 0.0 1.8e-09 37.7 0.0 2.0 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 ETO28274.1 - 7.8e-07 29.7 0.0 0.0017 18.9 0.0 3.9 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO28274.1 - 8.6e-05 22.8 0.2 0.00068 19.9 0.1 2.6 2 1 0 2 2 2 1 AAA domain NOB1_Zn_bind PF08772.11 ETO28274.1 - 0.0011 19.0 2.5 1.8 8.8 0.1 3.5 3 0 0 3 3 3 2 Nin one binding (NOB1) Zn-ribbon like bZIP_C PF12498.8 ETO28274.1 - 0.0064 17.5 0.2 5.5 8.0 0.0 3.2 3 0 0 3 3 2 1 Basic leucine-zipper C terminal RNA_helicase PF00910.22 ETO28274.1 - 0.0065 16.8 0.8 0.36 11.2 0.1 3.7 3 1 0 3 3 3 1 RNA helicase DUF2154 PF09922.9 ETO28274.1 - 0.011 15.5 0.0 13 5.6 0.0 4.1 4 0 0 4 4 4 0 Cell wall-active antibiotics response 4TMS YvqF zf-Mss51 PF13824.6 ETO28274.1 - 0.016 15.3 2.0 5.7 7.1 0.1 3.1 2 0 0 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 AAA_7 PF12775.7 ETO28274.1 - 0.016 14.7 0.0 0.041 13.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region Zn_Tnp_IS1595 PF12760.7 ETO28274.1 - 0.035 14.1 2.9 3.2 7.8 0.2 2.7 2 0 0 2 2 2 0 Transposase zinc-ribbon domain AAA_16 PF13191.6 ETO28274.1 - 0.074 13.4 0.1 1.8 8.9 0.0 2.8 2 1 0 2 2 2 0 AAA ATPase domain ABC_tran PF00005.27 ETO28274.1 - 0.1 13.1 0.3 0.66 10.5 0.0 2.6 3 0 0 3 3 3 0 ABC transporter zf-H2C2_2 PF13465.6 ETO28274.1 - 0.22 12.0 10.8 3.6 8.2 1.7 3.0 2 0 0 2 2 2 0 Zinc-finger double domain Zn-ribbon_8 PF09723.10 ETO28274.1 - 0.47 10.6 3.6 16 5.7 0.2 2.7 2 0 0 2 2 2 0 Zinc ribbon domain zf-C2H2 PF00096.26 ETO28274.1 - 2.4 8.8 9.4 18 6.0 1.3 3.3 2 0 0 2 2 2 0 Zinc finger, C2H2 type SLATT_5 PF18160.1 ETO28274.1 - 2.8 7.2 7.8 6.8 6.0 0.0 3.4 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF1610 PF07754.11 ETO28274.1 - 6 6.9 10.6 6.3 6.9 2.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1610) WD40 PF00400.32 ETO28275.1 - 1.6e-122 395.8 44.5 5.1e-10 39.8 0.8 16.3 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28275.1 - 2.8e-30 104.5 17.3 0.026 14.8 0.0 13.0 1 1 10 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28275.1 - 5.5e-19 68.3 4.8 0.21 10.5 0.0 10.7 4 3 8 13 13 13 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO28275.1 - 7.6e-13 48.4 20.0 0.0061 15.9 0.8 7.5 3 1 3 8 8 8 5 WD40-like domain Pentapeptide PF00805.22 ETO28275.1 - 2.6e-06 27.0 2.3 6.7e-06 25.6 2.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO28275.1 - 2.3e-05 24.4 0.4 20 5.4 0.0 6.5 6 1 1 7 7 7 0 Strictosidine synthase PD40 PF07676.12 ETO28275.1 - 8.4e-05 22.4 12.0 21 5.2 0.0 8.7 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO28275.1 - 0.00012 20.7 4.7 0.14 10.6 0.0 4.8 3 2 3 6 6 6 2 Cytochrome D1 heme domain Mid2 PF04478.12 ETO28275.1 - 0.0003 20.7 8.3 10 5.9 0.0 7.3 5 3 3 8 8 8 1 Mid2 like cell wall stress sensor Pentapeptide_4 PF13599.6 ETO28275.1 - 0.00091 19.4 0.5 0.0031 17.6 0.5 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO28275.1 - 0.0073 16.4 0.5 0.024 14.8 0.3 2.1 2 0 0 2 2 1 1 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO28275.1 - 0.012 15.6 4.7 17 5.6 0.0 6.6 8 0 0 8 8 8 0 Domain of unknown function (DUF3475) DUF3509 PF12021.8 ETO28275.1 - 0.027 14.2 0.0 17 5.2 0.0 4.0 4 0 0 4 4 4 0 Protein of unknown function (DUF3509) PDDEXK_4 PF14281.6 ETO28275.1 - 2 8.5 7.8 2.4 8.3 3.5 2.3 1 1 0 2 2 2 0 PD-(D/E)XK nuclease superfamily RGS PF00615.19 ETO28276.1 - 1.1e-05 25.7 0.0 3.3e-05 24.1 0.0 1.8 1 1 0 1 1 1 1 Regulator of G protein signaling domain Gly_transf_sug PF04488.15 ETO28277.1 - 2.1e-11 44.3 0.3 3.6e-11 43.5 0.3 1.4 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ETO28277.1 - 0.00017 21.0 0.3 0.00026 20.5 0.3 1.2 1 0 0 1 1 1 1 Capsular polysaccharide synthesis protein ATXN-1_C PF12547.8 ETO28277.1 - 0.099 13.0 0.0 2.1 8.7 0.0 2.6 2 0 0 2 2 2 0 Capicua transcriptional repressor modulator DUF2509 PF10713.9 ETO28278.1 - 0.86 9.7 5.0 0.42 10.7 0.2 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF2509) DHHC PF01529.20 ETO28279.1 - 0.02 15.0 0.1 0.027 14.6 0.1 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase MNSV_P7B PF06692.11 ETO28279.1 - 0.18 11.8 0.3 0.18 11.8 0.3 1.7 2 0 0 2 2 2 0 Melon necrotic spot virus P7B protein N6_Mtase PF02384.16 ETO28280.1 - 0.0056 16.0 4.7 0.0056 16.0 4.7 1.6 2 0 0 2 2 2 1 N-6 DNA Methylase XK-related PF09815.9 ETO28280.1 - 0.024 13.7 3.0 0.028 13.5 3.0 1.2 1 0 0 1 1 1 0 XK-related protein zf-LITAF-like PF10601.9 ETO28280.1 - 0.029 14.6 0.6 3.8 7.8 0.0 2.4 2 0 0 2 2 2 0 LITAF-like zinc ribbon domain DUF2208 PF09973.9 ETO28280.1 - 0.031 13.9 0.7 0.043 13.4 0.7 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) YniB PF14002.6 ETO28280.1 - 0.036 13.9 0.1 0.05 13.4 0.1 1.3 1 0 0 1 1 1 0 YniB-like protein 7TM_GPCR_Srd PF10317.9 ETO28280.1 - 0.07 12.3 3.3 0.2 10.8 3.3 1.6 1 1 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd ABC_membrane_2 PF06472.15 ETO28280.1 - 0.09 12.2 2.4 0.14 11.6 2.4 1.2 1 0 0 1 1 1 0 ABC transporter transmembrane region 2 O-antigen_lig PF13425.6 ETO28280.1 - 0.099 11.4 12.9 0.19 10.5 12.9 1.4 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Zip PF02535.22 ETO28280.1 - 0.13 11.5 10.1 1.4 8.0 10.1 2.0 1 1 0 1 1 1 0 ZIP Zinc transporter CSG2 PF16965.5 ETO28280.1 - 0.2 10.5 10.5 0.52 9.2 5.7 2.0 1 1 1 2 2 2 0 Ceramide synthase regulator SID-1_RNA_chan PF13965.6 ETO28280.1 - 0.3 9.5 12.5 1.9 6.8 12.5 1.9 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 7tm_1 PF00001.21 ETO28280.1 - 1.2 8.4 5.9 1.2 8.4 4.8 1.6 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Serinc PF03348.15 ETO28280.1 - 1.5 7.6 10.6 0.34 9.8 6.0 1.8 1 1 1 2 2 2 0 Serine incorporator (Serinc) Ctr PF04145.15 ETO28280.1 - 2.2 8.9 10.9 17 6.0 10.8 2.0 1 1 0 1 1 1 0 Ctr copper transporter family DHHC PF01529.20 ETO28280.1 - 2.5 8.2 10.1 0.19 11.8 4.1 2.0 1 1 1 2 2 2 0 DHHC palmitoyltransferase VKG_Carbox PF05090.14 ETO28280.1 - 2.7 6.8 9.4 0.23 10.2 3.7 2.0 1 1 2 3 3 3 0 Vitamin K-dependent gamma-carboxylase TMEM89 PF15098.6 ETO28280.1 - 3 8.0 7.3 2.1 8.5 5.5 1.8 1 1 0 1 1 1 0 TMEM89 protein family Scs3p PF10261.9 ETO28280.1 - 4.4 6.7 10.7 2.9 7.3 1.8 2.2 1 1 1 2 2 2 0 Inositol phospholipid synthesis and fat-storage-inducing TM Conotoxin PF02950.17 ETO28280.1 - 4.6 8.3 18.8 2.9 9.0 5.8 2.9 1 1 2 3 3 3 0 Conotoxin PTR2 PF00854.21 ETO28280.1 - 5.9 5.6 8.3 7.3 5.3 8.3 1.1 1 0 0 1 1 1 0 POT family Nucleoside_tran PF01733.18 ETO28280.1 - 9.7 5.5 9.1 1.9 7.8 5.3 1.6 1 1 1 2 2 2 0 Nucleoside transporter Stevor PF17410.2 ETO28281.1 - 1.5 8.3 11.4 0.044 13.3 2.6 2.3 1 1 0 2 2 2 0 Subtelomeric Variable Open Reading frame Beach PF02138.18 ETO28282.1 - 1.4e-119 398.6 0.1 8.3e-118 392.7 0.1 2.2 1 1 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO28282.1 - 8.9e-13 48.2 0.5 3e-12 46.5 0.5 1.9 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH Fungal_lectin_2 PF18647.1 ETO28282.1 - 0.0034 17.8 0.0 0.0087 16.5 0.0 1.7 1 0 0 1 1 1 1 Alpha-galactosyl-binding fungal lectin 7TM-7TMR_HD PF07698.11 ETO28282.1 - 0.067 13.0 1.0 0.11 12.3 1.0 1.3 1 0 0 1 1 1 0 7TM receptor with intracellular HD hydrolase DUF1722 PF08349.11 ETO28282.1 - 0.068 13.5 0.3 4.5 7.6 0.0 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1722) Methyltransf_12 PF08242.12 ETO28282.1 - 0.97 10.2 2.5 3.3 8.5 0.3 2.4 2 0 0 2 2 2 0 Methyltransferase domain Arginase PF00491.21 ETO28283.1 - 2.8e-32 112.3 0.0 3.5e-32 112.0 0.0 1.0 1 0 0 1 1 1 1 Arginase family Arginase PF00491.21 ETO28284.1 - 7.4e-16 58.5 0.0 3e-15 56.5 0.0 2.1 1 1 0 1 1 1 1 Arginase family UPF0489 PF12640.7 ETO28284.1 - 0.0022 18.2 0.1 0.0064 16.7 0.1 1.7 1 0 0 1 1 1 1 UPF0489 domain LMF1 PF06762.14 ETO28285.1 - 5.2e-78 263.1 9.1 2.3e-41 142.4 0.2 2.1 1 1 1 2 2 2 2 Lipase maturation factor WD40 PF00400.32 ETO28286.1 - 0.0097 16.7 9.1 0.016 16.1 1.0 4.2 4 1 1 5 5 5 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28286.1 - 0.017 15.4 0.1 0.39 11.0 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain HEAT_2 PF13646.6 ETO28287.1 - 2.5e-09 37.4 0.9 0.59 10.6 0.1 4.9 3 2 2 5 5 5 3 HEAT repeats HEAT PF02985.22 ETO28287.1 - 5.3e-09 35.6 0.9 0.21 11.9 0.0 4.5 3 0 0 3 3 3 3 HEAT repeat HEAT_EZ PF13513.6 ETO28287.1 - 4.2e-07 30.3 0.2 1.1 9.8 0.0 4.4 3 1 1 4 4 4 2 HEAT-like repeat RTP1_C1 PF10363.9 ETO28287.1 - 8.9e-07 29.1 2.3 0.1 12.8 0.0 4.5 2 1 2 4 4 4 2 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO28287.1 - 1.3e-06 28.9 4.9 0.018 15.6 0.1 4.8 2 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region DNA_pol3_gamma3 PF12169.8 ETO28287.1 - 0.0012 18.8 0.2 13 5.7 0.0 4.9 3 1 1 5 5 5 1 DNA polymerase III subunits gamma and tau domain III UME PF08064.13 ETO28287.1 - 0.0013 18.6 0.9 0.081 12.8 0.2 3.1 2 0 0 2 2 2 1 UME (NUC010) domain FPL PF09758.9 ETO28287.1 - 0.13 12.3 7.7 0.31 11.0 0.2 4.2 3 2 0 3 3 3 0 Uncharacterised conserved protein Utp13 PF08625.11 ETO28287.1 - 3.6 7.5 8.7 6.4 6.7 0.1 3.9 2 1 1 3 3 3 0 Utp13 specific WD40 associated domain Aa_trans PF01490.18 ETO28288.1 - 7.9e-44 150.0 13.9 1.1e-43 149.6 13.9 1.1 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein PAP_assoc PF03828.19 ETO28289.1 - 2.7e-08 33.9 0.5 2.1e-07 31.0 0.5 2.6 1 1 0 1 1 1 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETO28289.1 - 3.9e-05 23.9 0.1 0.00013 22.2 0.1 2.0 1 1 0 1 1 1 1 Nucleotidyltransferase domain DUF1923 PF09083.10 ETO28289.1 - 0.043 13.5 0.0 0.095 12.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1923) tRNA_NucTransf2 PF09249.11 ETO28289.1 - 0.086 13.1 0.0 0.43 10.8 0.0 2.2 2 0 0 2 2 2 0 tRNA nucleotidyltransferase, second domain HetR_C PF18460.1 ETO28291.1 - 0.21 11.5 3.5 0.27 11.2 0.9 2.4 2 1 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain Pkinase PF00069.25 ETO28292.1 - 0.00059 19.3 0.0 0.0008 18.9 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain RRM_1 PF00076.22 ETO28294.1 - 0.0046 16.8 0.0 0.0089 15.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Orf78 PF06024.12 ETO28295.1 - 0.0021 18.3 0.4 0.75 10.1 0.0 3.8 3 0 0 3 3 3 1 Orf78 (ac78) SARAF PF06682.12 ETO28295.1 - 0.028 14.1 0.1 1.7 8.2 0.0 2.3 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis Trypsin_2 PF13365.6 ETO28296.1 - 5.1e-22 79.4 1.2 1.1e-21 78.3 0.1 2.2 2 1 0 2 2 2 1 Trypsin-like peptidase domain Trypsin PF00089.26 ETO28296.1 - 2.2e-11 44.0 0.1 4.3e-10 39.8 0.1 2.3 1 1 0 1 1 1 1 Trypsin DUF563 PF04577.14 ETO28297.1 - 1.9e-09 38.0 0.2 3.7e-09 37.0 0.2 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF563) CelTOS PF18659.1 ETO28300.1 - 0.013 15.9 0.0 0.027 14.9 0.0 1.4 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites Kinesin PF00225.23 ETO28301.1 - 5e-34 117.7 0.4 5e-34 117.7 0.4 1.7 2 1 0 2 2 2 1 Kinesin motor domain Ax_dynein_light PF10211.9 ETO28301.1 - 0.0014 18.6 4.0 0.0026 17.7 4.0 1.5 1 0 0 1 1 1 1 Axonemal dynein light chain UPF0184 PF03670.13 ETO28301.1 - 0.017 15.5 1.8 9.6 6.7 0.0 2.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0184) LRRFIP PF09738.9 ETO28301.1 - 0.046 13.2 9.1 0.029 13.9 6.8 1.9 1 1 0 1 1 1 0 LRRFIP family SIKE PF05769.11 ETO28301.1 - 0.14 12.1 9.7 0.1 12.6 7.5 2.0 2 1 0 2 2 2 0 SIKE family Cauli_AT PF03233.13 ETO28301.1 - 0.31 10.9 4.6 1 9.2 4.5 2.0 1 1 0 1 1 1 0 Aphid transmission protein Nup54 PF13874.6 ETO28301.1 - 0.54 10.4 7.8 0.74 9.9 6.4 1.9 2 0 0 2 2 2 0 Nucleoporin complex subunit 54 Bcr-Abl_Oligo PF09036.10 ETO28301.1 - 0.85 9.7 5.1 13 5.9 1.0 2.3 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain A_thal_3526 PF09713.10 ETO28301.1 - 1.7 9.0 5.2 52 4.2 2.8 3.2 2 1 0 2 2 2 0 Plant protein 1589 of unknown function (A_thal_3526) DUF724 PF05266.14 ETO28301.1 - 5.2 6.9 10.4 2.1 8.1 6.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Enkurin PF13864.6 ETO28301.1 - 7.7 7.0 9.9 2.3 8.7 6.4 1.9 2 0 0 2 2 2 0 Calmodulin-binding FSH1 PF03959.13 ETO28302.1 - 0.59 9.8 5.0 7.1 6.2 0.8 2.3 2 0 0 2 2 2 0 Serine hydrolase (FSH1) DUF2312 PF10073.9 ETO28303.1 - 0.00054 19.5 3.1 0.00068 19.2 0.1 2.9 2 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2312) DEAD PF00270.29 ETO28304.1 - 1.4e-18 67.2 0.1 3.2e-18 66.1 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO28304.1 - 1.2e-15 57.8 5.8 1.7e-12 47.7 0.3 3.6 2 1 1 3 3 3 2 Helicase conserved C-terminal domain ResIII PF04851.15 ETO28304.1 - 1.2e-10 41.7 0.3 1.2e-10 41.7 0.3 3.0 4 0 0 4 4 4 1 Type III restriction enzyme, res subunit BUD22 PF09073.10 ETO28305.1 - 0.015 14.7 35.2 0.0078 15.6 21.6 2.2 2 0 0 2 2 2 0 BUD22 Vfa1 PF08432.10 ETO28305.1 - 1.6 9.0 28.2 0.77 10.1 1.0 3.4 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 RMI1_N PF08585.12 ETO28305.1 - 8.3 6.1 11.9 0.85 9.3 5.3 2.3 2 0 0 2 2 2 0 RecQ mediated genome instability protein NACHT PF05729.12 ETO28306.1 - 1.4e-08 34.8 0.0 2.1e-08 34.3 0.0 1.3 1 0 0 1 1 1 1 NACHT domain ATPase_2 PF01637.18 ETO28306.1 - 2.5e-06 27.6 0.0 3.5e-06 27.1 0.0 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO28306.1 - 4.4e-05 23.9 0.0 6.2e-05 23.5 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 ETO28306.1 - 0.00052 19.3 0.0 0.00083 18.6 0.0 1.2 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO28306.1 - 0.00092 19.5 0.0 0.0016 18.8 0.0 1.4 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ETO28306.1 - 0.061 13.3 0.0 0.09 12.8 0.0 1.3 1 0 0 1 1 1 0 Type III restriction enzyme, res subunit ORC2 PF04084.14 ETO28306.1 - 0.062 12.2 0.0 0.084 11.8 0.0 1.2 1 0 0 1 1 1 0 Origin recognition complex subunit 2 AAA_10 PF12846.7 ETO28306.1 - 0.094 11.6 0.0 0.19 10.6 0.0 1.5 2 0 0 2 2 2 0 AAA-like domain RsgA_GTPase PF03193.16 ETO28306.1 - 0.11 12.4 0.0 0.24 11.3 0.0 1.6 1 1 0 1 1 1 0 RsgA GTPase Sec20 PF03908.13 ETO28307.1 - 0.04 13.8 0.7 0.057 13.3 0.7 1.3 1 0 0 1 1 1 0 Sec20 TMEM247 PF15444.6 ETO28307.1 - 0.077 13.0 2.0 0.09 12.8 2.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 247 WD40 PF00400.32 ETO28308.1 - 2.3e-63 208.6 15.3 1.4e-11 44.7 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28308.1 - 2.5e-25 88.6 2.5 1.8e-05 24.9 0.0 6.6 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28308.1 - 1.1e-24 87.0 0.8 0.00069 18.7 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO28308.1 - 1.9e-11 43.8 2.2 2.2e-09 37.1 2.3 3.2 1 1 0 1 1 1 1 WD40-like domain eIF2A PF08662.11 ETO28308.1 - 2.5e-11 43.8 0.2 0.0014 18.6 0.0 3.4 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO28308.1 - 9.8e-09 34.9 11.8 1.1 9.3 0.0 6.8 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Utp8 PF10395.9 ETO28308.1 - 1.7e-06 26.9 0.9 0.01 14.4 0.1 3.2 1 1 1 4 4 4 2 Utp8 family Nup160 PF11715.8 ETO28308.1 - 3e-06 26.2 4.5 0.47 9.0 0.0 5.2 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO28308.1 - 2.1e-05 23.5 11.9 0.44 9.2 2.8 5.1 1 1 4 5 5 5 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO28308.1 - 2.1e-05 23.2 1.0 0.68 8.4 0.0 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO28308.1 - 0.00016 20.9 0.7 0.02 14.0 0.1 2.4 1 1 1 3 3 3 1 Coatomer WD associated region Nbas_N PF15492.6 ETO28308.1 - 0.00022 20.7 2.6 2.3 7.5 0.0 4.5 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO28308.1 - 0.00033 20.7 1.7 2 8.5 0.0 4.7 1 1 5 6 6 6 1 Family of unknown function (DUF5570) DUF1258 PF06869.12 ETO28308.1 - 0.002 17.7 0.5 0.65 9.4 0.0 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF1258) Gmad1 PF10647.9 ETO28308.1 - 0.0063 16.3 0.0 2.6 7.7 0.0 3.3 2 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain GspH PF12019.8 ETO28308.1 - 0.0067 16.8 0.1 16 5.9 0.1 3.6 1 1 2 3 3 3 0 Type II transport protein GspH DPPIV_N PF00930.21 ETO28308.1 - 0.016 14.0 0.2 14 4.3 0.0 4.0 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region IKI3 PF04762.12 ETO28308.1 - 0.081 10.9 0.9 1.4 6.8 0.2 2.7 1 1 1 3 3 3 0 IKI3 family gag_pre-integrs PF13976.6 ETO28308.1 - 0.23 11.3 1.9 3.8 7.5 0.0 3.8 6 0 0 6 6 5 0 GAG-pre-integrase domain Proteasome_A_N PF10584.9 ETO28308.1 - 0.42 10.3 8.8 20 4.9 0.1 4.9 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO28309.1 - 5.3e-08 32.9 2.8 0.003 17.8 0.0 3.7 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO28309.1 - 1.6e-07 30.8 2.4 0.0019 17.7 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO28309.1 - 1e-06 28.6 1.4 0.0012 18.7 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO28309.1 - 8.4e-06 25.6 0.4 0.016 15.2 0.1 2.7 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO28309.1 - 1.1e-05 25.6 0.0 7.7e-05 22.9 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain DUF2272 PF10030.9 ETO28309.1 - 0.00074 19.3 0.0 0.0019 18.0 0.0 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_4 PF13418.6 ETO28309.1 - 0.022 14.7 0.1 0.6 10.2 0.0 3.0 2 1 1 3 3 3 0 Galactose oxidase, central domain PulA_N1 PF17999.1 ETO28309.1 - 1.8 9.4 4.5 6.5 7.6 0.3 2.6 2 0 0 2 2 2 0 Pullulanase N1-terminal domain PBP1_TM PF14812.6 ETO28310.1 - 0.094 13.1 11.0 0.12 12.8 0.5 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mucin PF01456.17 ETO28310.1 - 0.68 9.9 15.2 0.31 11.0 12.2 1.9 2 0 0 2 2 2 0 Mucin-like glycoprotein SSP160 PF06933.11 ETO28310.1 - 6.1 4.9 11.7 8.6 4.4 11.7 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DUF3439 PF11921.8 ETO28310.1 - 8.2 6.4 12.1 5.5 7.0 9.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dynamin_N PF00350.23 ETO28311.1 - 8.5e-05 22.7 0.7 0.00013 22.1 0.7 1.4 1 0 0 1 1 1 1 Dynamin family G-alpha PF00503.20 ETO28311.1 - 0.003 16.8 1.3 0.0036 16.5 1.3 1.1 1 0 0 1 1 1 1 G-protein alpha subunit GTP_EFTU PF00009.27 ETO28311.1 - 0.033 13.7 0.1 0.067 12.7 0.1 1.6 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain Staphopain_pro PF14731.6 ETO28311.1 - 0.072 13.1 3.8 0.12 12.3 3.8 1.4 1 0 0 1 1 1 0 Staphopain proregion DUF2122 PF09895.9 ETO28312.1 - 0.17 12.3 0.9 0.5 10.8 0.9 1.7 1 0 0 1 1 1 0 RecB-family nuclease (DUF2122) Mitofilin PF09731.9 ETO28313.1 - 0.00069 18.6 1.2 0.0012 17.8 1.2 1.4 1 1 0 1 1 1 1 Mitochondrial inner membrane protein zf-C4H2 PF10146.9 ETO28313.1 - 0.06 13.6 1.5 0.073 13.4 1.5 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF3964 PF13107.6 ETO28313.1 - 0.07 13.5 0.0 0.12 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3964) Jnk-SapK_ap_N PF09744.9 ETO28313.1 - 0.085 13.1 5.6 0.15 12.3 5.6 1.4 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Uteroglobin PF01099.17 ETO28313.1 - 0.15 12.4 0.5 0.32 11.4 0.5 1.6 1 0 0 1 1 1 0 Uteroglobin family Rap_GAP PF02145.15 ETO28314.1 - 3.1e-42 144.2 0.0 5.2e-42 143.5 0.0 1.3 1 0 0 1 1 1 1 Rap/ran-GAP Phage_holin_4_1 PF05105.12 ETO28315.1 - 0.11 12.6 0.0 0.39 10.9 0.0 2.0 2 0 0 2 2 2 0 Bacteriophage holin family FAT PF02259.23 ETO28318.1 - 3.4e-61 207.4 20.2 2e-46 158.8 2.9 4.5 5 1 0 5 5 5 2 FAT domain FRB_dom PF08771.11 ETO28318.1 - 3.4e-28 98.0 7.9 3.4e-28 98.0 7.9 4.5 4 0 0 4 4 4 2 FKBP12-rapamycin binding domain TPR_14 PF13428.6 ETO28318.1 - 0.16 12.9 1.1 25 6.0 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat CENP-B_dimeris PF09026.10 ETO28318.1 - 6.1 7.3 13.3 1.5 9.3 6.7 2.8 2 0 0 2 2 2 0 Centromere protein B dimerisation domain DUF3385 PF11865.8 ETO28319.1 - 1.2e-16 61.0 15.5 6.9e-14 52.1 3.6 6.1 5 2 0 5 5 5 2 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 ETO28319.1 - 2.9e-06 27.6 0.0 0.055 13.9 0.0 4.5 4 1 0 4 4 4 2 HEAT repeats HEAT_EZ PF13513.6 ETO28319.1 - 0.0011 19.4 5.8 2.8 8.6 0.0 5.2 5 1 1 6 6 6 1 HEAT-like repeat HEAT PF02985.22 ETO28319.1 - 0.041 14.1 6.8 3 8.3 0.0 5.6 5 0 0 5 5 5 0 HEAT repeat Arm PF00514.23 ETO28319.1 - 1 9.5 7.5 1.5 9.0 0.1 4.7 6 0 0 6 6 6 0 Armadillo/beta-catenin-like repeat Zip PF02535.22 ETO28320.1 - 1.8 7.7 11.3 1.1 8.5 0.9 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter ASFV_J13L PF05568.11 ETO28321.1 - 0.15 11.8 0.0 0.31 10.8 0.0 1.4 1 1 0 1 1 1 0 African swine fever virus J13L protein DUF2052 PF09747.9 ETO28323.1 - 1.1 9.3 12.4 3.8 7.6 0.1 2.8 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) V-ATPase_H_C PF11698.8 ETO28325.1 - 0.05 13.7 2.4 0.096 12.8 1.1 2.1 2 0 0 2 2 2 0 V-ATPase subunit H DUF1031 PF06275.11 ETO28325.1 - 0.26 11.5 3.6 1 9.6 0.0 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1031) nsp7 PF08716.10 ETO28325.1 - 0.99 10.1 4.4 0.47 11.1 1.6 1.9 2 0 0 2 2 2 0 nsp7 replicase DUF4763 PF15960.5 ETO28327.1 - 6.6e-05 22.3 8.6 6.6e-05 22.3 8.6 2.2 2 1 0 2 2 2 1 Domain of unknown function (DUF4763) DUF3794 PF12673.7 ETO28327.1 - 0.6 10.4 4.0 0.27 11.5 0.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3794) Spc7 PF08317.11 ETO28327.1 - 0.62 8.9 25.1 0.065 12.1 17.6 2.4 2 1 0 2 2 2 0 Spc7 kinetochore protein UPF0242 PF06785.11 ETO28327.1 - 2.7 8.1 21.0 0.068 13.3 13.1 2.1 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DivIC PF04977.15 ETO28327.1 - 2.8 7.8 12.8 0.4 10.5 7.8 2.2 2 0 0 2 2 2 0 Septum formation initiator OMP_b-brl PF13505.6 ETO28328.1 - 4.1e-11 43.3 0.7 6.2e-11 42.7 0.7 1.2 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain Opacity PF02462.15 ETO28328.1 - 0.00083 19.5 0.2 0.0016 18.6 0.2 1.4 1 0 0 1 1 1 1 Opacity family porin protein OmpA_membrane PF01389.17 ETO28328.1 - 0.0011 18.7 0.1 0.0017 18.1 0.1 1.3 1 0 0 1 1 1 1 OmpA-like transmembrane domain Surface_Ag_2 PF01617.17 ETO28328.1 - 0.014 14.8 0.5 0.031 13.7 0.5 1.5 1 0 0 1 1 1 0 Surface antigen MtrB_PioB PF11854.8 ETO28328.1 - 0.053 11.9 0.1 0.074 11.4 0.1 1.1 1 0 0 1 1 1 0 Putative outer membrane beta-barrel porin, MtrB/PioB PagL PF09411.10 ETO28328.1 - 0.085 13.0 0.2 0.24 11.6 0.2 1.7 1 1 1 2 2 2 0 Lipid A 3-O-deacylase (PagL) ubiquitin PF00240.23 ETO28331.1 - 7.2e-15 54.5 1.5 9.7e-15 54.1 1.5 1.1 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO28331.1 - 3e-09 36.6 2.0 4e-09 36.2 2.0 1.2 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO28331.1 - 0.0006 20.3 0.0 0.00071 20.1 0.0 1.1 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Rad60-SLD_2 PF13881.6 ETO28331.1 - 0.046 13.8 0.3 0.14 12.2 0.3 1.8 1 1 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO28331.1 - 0.061 13.8 0.1 0.077 13.5 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Myelin_MBP PF01669.17 ETO28332.1 - 0.085 13.5 0.1 0.15 12.7 0.1 1.3 1 0 0 1 1 1 0 Myelin basic protein DUF1878 PF08963.10 ETO28333.1 - 0.11 12.9 6.8 0.12 12.9 0.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1878) Ras PF00071.22 ETO28335.1 - 8.7e-12 44.9 0.2 4.7e-08 32.8 0.2 3.4 1 1 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ETO28335.1 - 0.00084 19.4 0.0 0.006 16.6 0.0 2.4 2 1 1 3 3 3 1 50S ribosome-binding GTPase Roc PF08477.13 ETO28335.1 - 0.056 13.7 0.9 0.16 12.2 0.1 2.2 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TMCO5 PF14992.6 ETO28336.1 - 0.13 11.8 2.7 3.6 7.1 1.9 2.0 1 1 1 2 2 2 0 TMCO5 family DUF3965 PF13112.6 ETO28338.1 - 0.039 13.2 0.0 0.039 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3965) DUF2092 PF09865.9 ETO28338.1 - 0.11 11.8 0.0 0.13 11.6 0.0 1.1 1 0 0 1 1 1 0 Predicted periplasmic protein (DUF2092) C2 PF00168.30 ETO28339.1 - 5.2e-09 36.3 0.2 3.3e-08 33.7 0.1 2.4 2 0 0 2 2 2 1 C2 domain DUF1192 PF06698.11 ETO28339.1 - 0.0011 19.0 1.4 0.0045 17.0 1.4 2.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1192) DivIC PF04977.15 ETO28339.1 - 0.0042 16.8 2.0 0.0042 16.8 2.0 4.2 1 1 3 4 4 4 1 Septum formation initiator WD40_alt PF14077.6 ETO28339.1 - 0.025 14.4 0.3 0.13 12.2 0.1 2.2 2 0 0 2 2 2 0 Alternative WD40 repeat motif MYO10_CC PF16735.5 ETO28339.1 - 0.049 13.7 0.4 0.049 13.7 0.4 2.2 2 1 0 2 2 2 0 Unconventional myosin-X coiled coil domain Titin_Z PF09042.11 ETO28339.1 - 0.11 12.4 10.0 0.17 11.9 3.9 3.1 3 0 0 3 3 3 0 Titin Z JIP_LZII PF16471.5 ETO28339.1 - 0.15 12.2 7.4 0.57 10.4 0.2 3.0 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II DUF1664 PF07889.12 ETO28339.1 - 0.16 12.0 14.1 0.35 10.9 4.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Cnn_1N PF07989.11 ETO28339.1 - 0.16 12.1 16.5 1 9.6 2.2 3.7 1 1 3 4 4 4 0 Centrosomin N-terminal motif 1 GAS PF13851.6 ETO28339.1 - 0.32 10.3 23.2 0.052 12.9 11.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding CENP-F_leu_zip PF10473.9 ETO28339.1 - 0.55 10.2 21.6 10 6.1 8.9 3.0 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 KLRAQ PF10205.9 ETO28339.1 - 0.57 10.5 20.3 2.7 8.3 5.1 2.2 1 1 1 2 2 2 0 Predicted coiled-coil domain-containing protein Prominin PF05478.11 ETO28339.1 - 0.62 7.9 11.6 0.15 10.0 8.4 1.5 1 1 1 2 2 2 0 Prominin YabA PF06156.13 ETO28339.1 - 0.81 10.4 18.6 2.8 8.6 7.3 2.4 1 1 1 2 2 2 0 Initiation control protein YabA Shugoshin_N PF07558.11 ETO28339.1 - 0.82 9.6 7.6 15 5.6 0.3 3.6 3 1 1 4 4 4 0 Shugoshin N-terminal coiled-coil region Golgin_A5 PF09787.9 ETO28339.1 - 1 8.8 22.5 0.82 9.1 19.2 1.9 1 1 1 2 2 2 0 Golgin subfamily A member 5 Csm1_N PF18504.1 ETO28339.1 - 2.3 8.6 22.9 1.9 8.9 6.4 3.4 2 1 1 3 3 3 0 Csm1 N-terminal domain BLOC1_2 PF10046.9 ETO28339.1 - 3.2 8.1 17.3 0.041 14.2 6.5 2.7 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Jnk-SapK_ap_N PF09744.9 ETO28339.1 - 3.3 7.9 23.4 3.6 7.8 2.3 2.3 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 Rootletin PF15035.6 ETO28339.1 - 4.7 7.2 21.4 23 4.9 11.3 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion DivIVA PF05103.13 ETO28339.1 - 8.3 6.5 21.0 1.9e+02 2.1 20.7 2.4 1 1 0 1 1 1 0 DivIVA protein COG2 PF06148.11 ETO28339.1 - 8.5 6.5 13.5 1.1 9.3 4.7 2.6 1 1 1 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 His_Phos_2 PF00328.22 ETO28340.1 - 3.2e-12 46.5 0.2 2.5e-09 37.0 0.3 2.8 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 2) His_Phos_1 PF00300.22 ETO28340.1 - 0.068 12.9 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 Histidine phosphatase superfamily (branch 1) LMF1 PF06762.14 ETO28342.1 - 4.8e-23 82.0 5.1 4.1e-21 75.6 5.1 2.7 1 1 0 1 1 1 1 Lipase maturation factor Pkinase PF00069.25 ETO28343.1 - 7.1e-68 228.8 0.0 7.1e-68 228.8 0.0 2.0 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28343.1 - 4.1e-31 108.2 0.0 1.1e-30 106.8 0.0 1.7 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4360 PF14273.6 ETO28344.1 - 1.1 9.1 4.8 0.37 10.7 2.0 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4360) Apq12 PF12716.7 ETO28344.1 - 8.1 6.5 9.4 18 5.3 9.4 1.6 1 0 0 1 1 1 0 Nuclear pore assembly and biogenesis Aminotran_3 PF00202.21 ETO28346.1 - 7.6e-12 44.6 0.0 9.5e-12 44.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_3 PF00202.21 ETO28347.1 - 8.1e-25 87.3 0.0 9.4e-25 87.1 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III SAM_2 PF07647.17 ETO28348.1 - 1.9e-10 40.7 0.4 3.2e-10 40.0 0.4 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO28348.1 - 2.3e-10 40.8 0.5 4.1e-10 40.0 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PCRF PF03462.18 ETO28348.1 - 0.64 9.8 6.6 1.1 9.2 3.5 2.3 2 1 0 2 2 2 0 PCRF domain BLOC1_2 PF10046.9 ETO28348.1 - 1.3 9.3 8.8 2.3 8.6 2.1 3.2 2 1 2 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Snapin_Pallidin PF14712.6 ETO28348.1 - 1.3 9.4 10.2 0.17 12.3 4.3 2.3 2 0 0 2 2 2 0 Snapin/Pallidin bZIP_1 PF00170.21 ETO28348.1 - 1.7 8.8 7.7 0.12 12.5 1.0 2.4 3 0 0 3 3 3 0 bZIP transcription factor Uso1_p115_C PF04871.13 ETO28348.1 - 2.6 8.4 14.3 0.37 11.1 5.8 2.8 3 0 0 3 3 3 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF724 PF05266.14 ETO28348.1 - 3.7 7.3 11.4 1.1 9.1 6.8 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF724) FapA PF03961.13 ETO28348.1 - 3.8 6.0 10.7 1.4 7.4 7.4 1.7 1 1 1 2 2 2 0 Flagellar Assembly Protein A Fib_alpha PF08702.10 ETO28348.1 - 7.3 6.8 16.0 0.45 10.7 4.8 3.1 2 2 2 4 4 4 0 Fibrinogen alpha/beta chain family Pkinase PF00069.25 ETO28349.1 - 4.1e-07 29.7 0.2 8.2e-07 28.7 0.2 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28349.1 - 6.3e-07 28.9 0.1 1.4e-06 27.8 0.0 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase DUF3874 PF12990.7 ETO28349.1 - 0.0013 19.0 0.3 0.026 14.8 0.1 2.9 3 0 0 3 3 3 1 Domain of unknonw function from B. Theta Gene description (DUF3874) m04gp34like PF12216.8 ETO28349.1 - 0.016 14.8 0.1 0.038 13.6 0.1 1.6 1 0 0 1 1 1 0 Immune evasion protein FTR1 PF03239.14 ETO28349.1 - 0.43 9.7 1.9 0.54 9.4 0.3 1.9 2 0 0 2 2 2 0 Iron permease FTR1 family MMS1_N PF10433.9 ETO28350.1 - 3.3e-141 471.3 0.0 7e-141 470.2 0.0 1.5 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term CPSF_A PF03178.15 ETO28350.1 - 2.9e-61 207.6 0.8 2.9e-61 207.6 0.8 1.6 2 0 0 2 2 2 1 CPSF A subunit region RasGAP PF00616.19 ETO28351.1 - 5.5e-24 85.0 0.0 5.5e-24 85.0 0.0 2.9 3 1 0 3 3 3 1 GTPase-activator protein for Ras-like GTPase RasGAP_C PF03836.15 ETO28351.1 - 1.2e-10 41.6 3.9 1.2e-10 41.6 3.9 2.5 3 1 0 3 3 3 1 RasGAP C-terminus Apolipoprotein PF01442.18 ETO28351.1 - 0.01 15.7 1.3 0.021 14.7 0.1 2.0 2 1 0 2 2 2 0 Apolipoprotein A1/A4/E domain NPV_P10 PF05531.12 ETO28351.1 - 0.01 16.3 0.4 0.38 11.3 0.0 3.3 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein Hrs_helical PF12210.8 ETO28351.1 - 0.017 15.7 6.8 2.7 8.6 0.1 4.1 2 1 1 3 3 3 0 Hepatocyte growth factor-regulated tyrosine kinase substrate TPR_20 PF14561.6 ETO28351.1 - 0.049 14.0 0.3 0.73 10.2 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat LOH1CR12 PF10158.9 ETO28351.1 - 0.35 10.9 5.2 2.3 8.3 0.4 3.1 3 0 0 3 3 3 0 Tumour suppressor protein RasGAP PF00616.19 ETO28352.1 - 4.4e-11 42.9 0.4 5.7e-11 42.5 0.4 1.2 1 0 0 1 1 1 1 GTPase-activator protein for Ras-like GTPase InPase PF18823.1 ETO28352.1 - 0.0054 16.4 0.1 0.0074 16.0 0.1 1.1 1 0 0 1 1 1 1 Inorganic Pyrophosphatase ZapB PF06005.12 ETO28353.1 - 0.0073 16.7 0.2 0.0073 16.7 0.2 3.4 1 1 1 2 2 1 1 Cell division protein ZapB DUF2304 PF10066.9 ETO28353.1 - 0.062 13.5 0.5 0.19 11.9 0.3 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2304) Phage_Mu_F PF04233.14 ETO28353.1 - 0.59 10.9 4.9 5.3 7.8 4.9 2.2 1 1 0 1 1 1 0 Phage Mu protein F like protein Reprolysin_5 PF13688.6 ETO28353.1 - 0.75 9.9 6.1 2.9 8.0 0.3 2.2 1 1 1 2 2 2 0 Metallo-peptidase family M12 DUF1640 PF07798.11 ETO28353.1 - 1.1 9.3 29.1 0.055 13.5 19.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1640) OmpH PF03938.14 ETO28353.1 - 1.4 9.3 33.5 5.9 7.2 8.2 2.4 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 ETO28353.1 - 3.5 6.9 18.8 14 4.9 18.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) RHD_DNA_bind PF00554.22 ETO28353.1 - 3.7 7.4 10.9 0.81 9.6 4.4 2.1 1 1 1 2 2 2 0 Rel homology DNA-binding domain TPR_MLP1_2 PF07926.12 ETO28353.1 - 4 7.5 37.5 21 5.2 34.6 2.9 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein FUSC PF04632.12 ETO28353.1 - 5.1 5.5 4.4 6.7 5.1 4.4 1.2 1 0 0 1 1 1 0 Fusaric acid resistance protein family HalX PF08663.10 ETO28353.1 - 5.8 7.3 11.6 3.8 7.9 0.2 2.7 3 0 0 3 3 3 0 HalX domain DUF3698 PF12479.8 ETO28353.1 - 7.1 7.2 12.3 0.6 10.7 1.5 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF3698) Acetyltransf_1 PF00583.25 ETO28354.1 - 6.9e-16 58.5 0.0 1.1e-15 57.9 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO28354.1 - 5.4e-12 45.8 0.0 9.7e-12 44.9 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO28354.1 - 3.4e-11 43.4 0.0 5.1e-11 42.8 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO28354.1 - 3.1e-09 36.7 0.0 5.5e-09 35.9 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ETO28354.1 - 7.5e-07 29.4 1.2 8.1e-07 29.3 0.4 1.5 1 1 1 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_8 PF13523.6 ETO28354.1 - 7.7e-06 25.7 0.2 1.4e-05 24.8 0.0 1.5 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_3 PF13302.7 ETO28354.1 - 2e-05 25.3 0.0 3.1e-05 24.7 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_CG PF14542.6 ETO28354.1 - 0.0076 16.4 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_9 PF13527.7 ETO28354.1 - 0.013 15.6 0.0 0.02 14.9 0.0 1.4 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain RPS31 PF17067.5 ETO28355.1 - 0.22 11.7 4.4 7.2 6.8 0.4 3.2 3 0 0 3 3 3 0 Ribosomal protein S31e DUF3987 PF13148.6 ETO28355.1 - 0.33 9.9 6.8 0.2 10.7 3.4 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF3987) Abhydrolase_5 PF12695.7 ETO28356.1 - 0.032 14.0 0.1 0.04 13.7 0.1 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Tox-HNH-HHH PF15637.6 ETO28356.1 - 0.1 12.7 1.9 0.14 12.3 1.6 1.5 1 1 0 1 1 1 0 HNH/Endo VII superfamily nuclease toxin with a HHH motif WD40 PF00400.32 ETO28357.1 - 6e-42 140.8 6.9 1.3e-09 38.5 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28357.1 - 6.7e-13 48.8 0.9 0.0033 17.7 0.0 5.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28357.1 - 1.6e-09 37.2 0.1 0.032 13.2 0.0 4.6 1 1 4 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO28357.1 - 1.2e-06 27.5 6.0 0.29 9.7 0.1 4.4 1 1 3 5 5 5 3 Nucleoporin Nup120/160 VID27 PF08553.10 ETO28357.1 - 1.7e-06 27.4 0.1 0.0013 17.8 0.0 2.9 2 1 1 3 3 3 2 VID27 C-terminal WD40-like domain Cytochrom_D1 PF02239.16 ETO28357.1 - 1.7e-06 26.8 0.1 0.00076 18.1 0.0 2.8 1 1 2 3 3 3 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO28357.1 - 4.7e-06 26.1 0.6 0.0016 17.8 0.0 3.7 2 2 1 3 3 3 1 WD40-like domain PD40 PF07676.12 ETO28357.1 - 3.8e-05 23.5 0.4 0.021 14.8 0.0 3.8 4 1 0 4 4 4 1 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETO28357.1 - 0.038 12.3 0.2 0.3 9.3 0.1 2.3 1 1 1 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz Proteasome_A_N PF10584.9 ETO28357.1 - 0.13 12.0 0.4 87 2.9 0.0 4.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature TFIIA PF03153.13 ETO28358.1 - 0.26 11.3 20.3 0.35 10.8 20.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 ETO28358.1 - 0.37 9.3 14.4 0.43 9.1 14.4 1.2 1 0 0 1 1 1 0 Macoilin family Med3 PF11593.8 ETO28358.1 - 1.1 8.3 39.6 1.8 7.7 39.6 1.2 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Hamartin PF04388.12 ETO28358.1 - 3.4 6.2 26.4 4.5 5.8 26.4 1.1 1 0 0 1 1 1 0 Hamartin protein DUF4834 PF16118.5 ETO28359.1 - 0.23 12.5 8.1 0.27 12.2 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF4518 PF15008.6 ETO28359.1 - 2.1 7.5 6.7 2.8 7.0 1.7 2.6 2 2 0 2 2 2 0 Domain of unknown function (DUF4518) WD40 PF00400.32 ETO28360.1 - 1.6e-16 60.3 10.0 8.9e-05 23.2 0.2 5.5 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28360.1 - 0.0012 19.1 1.6 0.23 11.8 0.9 3.8 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Inos-1-P_synth PF01658.17 ETO28360.1 - 1.5 9.1 4.4 4 7.7 0.1 2.4 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase zf-TRAF PF02176.18 ETO28361.1 - 9.8e-12 45.4 6.4 9.8e-12 45.4 6.4 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger PH PF00169.29 ETO28361.1 - 3.5e-06 27.5 0.7 8.2e-06 26.3 0.1 2.0 2 0 0 2 2 2 1 PH domain PH_11 PF15413.6 ETO28361.1 - 3.7e-05 24.1 6.6 0.00012 22.5 0.1 3.0 2 1 0 3 3 3 1 Pleckstrin homology domain TelA PF05816.11 ETO28361.1 - 0.0001 21.5 4.3 0.00015 21.0 4.3 1.2 1 0 0 1 1 1 1 Toxic anion resistance protein (TelA) PH_3 PF14593.6 ETO28361.1 - 0.0012 18.9 3.4 0.0022 18.1 0.3 2.4 2 0 0 2 2 2 1 PH domain DUF1664 PF07889.12 ETO28361.1 - 0.031 14.3 1.0 0.031 14.3 1.0 2.4 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) PH_15 PF17339.2 ETO28361.1 - 0.046 13.6 0.7 0.27 11.2 0.1 2.3 2 0 0 2 2 2 0 PH domain PH_8 PF15409.6 ETO28361.1 - 0.075 13.3 2.1 0.081 13.2 0.1 2.1 2 1 1 3 3 3 0 Pleckstrin homology domain DUF4047 PF13256.6 ETO28361.1 - 0.77 10.0 5.0 0.35 11.1 1.8 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) G-patch PF01585.23 ETO28362.1 - 1.4e-07 31.3 0.6 3.1e-07 30.2 0.6 1.7 1 0 0 1 1 1 1 G-patch domain TIP_N PF12457.8 ETO28362.1 - 6.3e-07 29.7 3.4 6.3e-07 29.7 3.4 3.7 2 1 2 4 4 4 1 Tuftelin interacting protein N terminal G-patch_2 PF12656.7 ETO28362.1 - 8.5 6.5 16.5 1.7 8.8 1.9 4.1 3 0 0 3 3 3 0 G-patch domain Rab3-GTPase_cat PF13890.6 ETO28363.1 - 2.4e-07 30.5 0.1 2.4e-07 30.5 0.1 2.1 3 0 0 3 3 3 1 Rab3 GTPase-activating protein catalytic subunit DUF2207 PF09972.9 ETO28364.1 - 0.0015 17.4 5.6 0.0015 17.4 5.6 2.2 1 1 1 2 2 2 1 Predicted membrane protein (DUF2207) Spectrin PF00435.21 ETO28364.1 - 0.58 10.7 23.1 2.2 8.8 2.0 3.5 2 1 1 3 3 3 0 Spectrin repeat Sec34 PF04136.15 ETO28364.1 - 0.95 9.3 18.4 0.65 9.9 2.4 3.3 2 1 1 3 3 3 0 Sec34-like family DivIC PF04977.15 ETO28365.1 - 0.03 14.1 6.7 0.19 11.5 0.3 2.2 1 1 1 2 2 2 0 Septum formation initiator RasGAP_C PF03836.15 ETO28365.1 - 0.14 12.3 3.1 2.3 8.3 0.3 2.0 2 0 0 2 2 2 0 RasGAP C-terminus Cytomega_UL84 PF06284.11 ETO28366.1 - 1.5 7.2 9.8 0.58 8.6 2.7 2.2 2 0 0 2 2 2 0 Cytomegalovirus UL84 protein AC_N PF16214.5 ETO28366.1 - 2.4 7.2 4.7 3.7 6.6 4.7 1.2 1 0 0 1 1 1 0 Adenylyl cyclase N-terminal extracellular and transmembrane region DUF2722 PF10846.8 ETO28367.1 - 0.00012 21.1 3.9 0.00012 21.1 3.9 5.2 3 2 2 5 5 5 1 Protein of unknown function (DUF2722) Kelch_2 PF07646.15 ETO28368.1 - 0.04 13.9 2.9 22 5.2 0.8 4.1 3 1 0 3 3 3 0 Kelch motif Sporozoite_P67 PF05642.11 ETO28370.1 - 0.34 8.9 11.2 0.54 8.3 11.2 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NPR3 PF03666.13 ETO28371.1 - 0.02 13.7 4.8 0.12 11.2 2.0 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Secretin_N_2 PF07655.13 ETO28371.1 - 0.11 13.0 19.7 0.21 12.2 19.7 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Ashwin PF15323.6 ETO28371.1 - 0.18 11.8 5.6 0.25 11.3 5.6 1.2 1 0 0 1 1 1 0 Developmental protein Menin PF05053.13 ETO28371.1 - 0.36 9.1 5.8 0.39 9.0 5.8 1.1 1 0 0 1 1 1 0 Menin NOA36 PF06524.12 ETO28371.1 - 4.1 6.6 9.3 5.8 6.1 9.3 1.1 1 0 0 1 1 1 0 NOA36 protein DUF4820 PF16091.5 ETO28371.1 - 4.7 6.5 5.8 7.4 5.9 5.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Zip PF02535.22 ETO28371.1 - 9.4 5.3 6.0 14 4.7 5.8 1.4 1 1 0 1 1 1 0 ZIP Zinc transporter Nup96 PF12110.8 ETO28372.1 - 1.3e-08 34.3 0.0 0.0021 17.3 0.0 2.6 2 0 0 2 2 2 2 Nuclear protein 96 PUB PF09409.10 ETO28374.1 - 0.017 15.0 1.4 0.18 11.7 1.4 2.4 1 1 0 1 1 1 0 PUB domain DNA_pol_phi PF04931.13 ETO28374.1 - 0.044 11.9 1.6 0.051 11.7 1.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi Glyco_trans_4_5 PF16994.5 ETO28374.1 - 0.13 11.9 0.7 0.18 11.4 0.7 1.2 1 0 0 1 1 1 0 Glycosyl-transferase family 4 DUF2052 PF09747.9 ETO28375.1 - 0.00048 20.3 2.5 0.00095 19.4 2.5 1.6 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Pox_Ag35 PF03286.14 ETO28375.1 - 0.00083 19.2 6.3 0.0016 18.2 6.3 1.6 1 0 0 1 1 1 1 Pox virus Ag35 surface protein CDC45 PF02724.14 ETO28375.1 - 0.0034 15.8 5.3 0.0051 15.2 5.3 1.2 1 0 0 1 1 1 1 CDC45-like protein CobT PF06213.12 ETO28375.1 - 0.075 12.4 5.5 0.12 11.8 5.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Sigma70_ner PF04546.13 ETO28375.1 - 0.32 10.8 12.8 0.029 14.3 4.0 2.9 3 0 0 3 3 3 0 Sigma-70, non-essential region FAM176 PF14851.6 ETO28375.1 - 0.37 10.4 6.6 0.96 9.1 6.6 1.7 1 0 0 1 1 1 0 FAM176 family DUF2457 PF10446.9 ETO28375.1 - 0.94 8.6 19.5 1.4 7.9 19.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) RNA_pol_3_Rpc31 PF11705.8 ETO28375.1 - 1 9.5 15.6 1.8 8.7 15.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DNA_pol_phi PF04931.13 ETO28375.1 - 1.3 7.0 18.1 1.4 6.9 15.6 2.0 2 0 0 2 2 2 0 DNA polymerase phi Nop14 PF04147.12 ETO28375.1 - 2.5 6.2 15.9 4.5 5.4 15.9 1.4 1 0 0 1 1 1 0 Nop14-like family DUF4569 PF15133.6 ETO28375.1 - 2.8 7.6 9.3 0.9 9.2 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4569) TFB6 PF17110.5 ETO28375.1 - 3.5 7.4 7.2 4.2 7.1 5.7 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Secretin_N_2 PF07655.13 ETO28376.1 - 0.77 10.3 13.4 2.2 8.9 13.4 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain PI3_PI4_kinase PF00454.27 ETO28377.1 - 5.5e-17 62.4 5.3 1.2e-09 38.3 0.1 3.2 3 1 1 4 4 4 2 Phosphatidylinositol 3- and 4-kinase RPM2 PF08579.11 ETO28377.1 - 0.037 14.4 0.2 6.5 7.2 0.1 2.7 2 0 0 2 2 2 0 Mitochondrial ribonuclease P subunit (RPM2) DUF4854 PF16146.5 ETO28377.1 - 0.052 13.9 0.1 0.21 11.9 0.1 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4854) Pur_ac_phosph_N PF16656.5 ETO28378.1 - 7.7e-08 32.8 0.6 2.5e-07 31.1 0.6 2.0 1 0 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain fn3 PF00041.21 ETO28378.1 - 3e-07 30.7 1.3 3e-07 30.7 1.3 2.7 2 1 0 2 2 2 1 Fibronectin type III domain Esterase PF00756.20 ETO28379.1 - 4.8e-10 39.5 0.1 6e-09 35.9 0.1 2.1 1 1 0 1 1 1 1 Putative esterase HALZ PF02183.18 ETO28380.1 - 0.0042 17.3 1.5 0.0042 17.3 1.5 3.4 2 1 0 2 2 2 1 Homeobox associated leucine zipper AcetylCoA_hydro PF02550.15 ETO28381.1 - 2.9e-09 37.2 0.0 6.6e-09 36.0 0.0 1.5 1 1 0 1 1 1 1 Acetyl-CoA hydrolase/transferase N-terminal domain Pkinase PF00069.25 ETO28382.1 - 1.6e-39 135.9 3.2 1.8e-28 99.6 0.1 2.3 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28382.1 - 1.2e-15 57.6 0.5 7.1e-09 35.3 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase PF00069.25 ETO28383.1 - 0.0095 15.3 2.4 0.014 14.8 1.0 1.9 2 0 0 2 2 2 1 Protein kinase domain UFD1 PF03152.14 ETO28383.1 - 0.085 12.3 0.4 0.15 11.5 0.4 1.4 1 0 0 1 1 1 0 Ubiquitin fusion degradation protein UFD1 FH2 PF02181.23 ETO28384.1 - 6.5e-15 55.1 4.4 6.5e-15 55.1 4.4 4.7 3 2 1 4 4 4 1 Formin Homology 2 Domain CCDC53 PF10152.9 ETO28384.1 - 7.4e-06 26.5 4.3 0.00095 19.6 0.6 8.0 6 2 1 7 7 7 4 Subunit CCDC53 of WASH complex Takusan PF04822.13 ETO28384.1 - 0.0012 18.7 3.6 0.0012 18.7 3.6 5.2 4 0 0 4 4 4 1 Takusan HlyD_D4 PF16572.5 ETO28384.1 - 0.047 13.6 3.0 29 4.6 0.0 4.0 3 0 0 3 3 3 0 Long alpha hairpin domain of cation efflux system protein, CusB PI_PP_I PF18363.1 ETO28384.1 - 0.37 11.0 9.8 2.8 8.2 0.7 3.2 2 1 0 2 2 2 0 Phosphoinositide phosphatase insertion domain FH2 PF02181.23 ETO28385.1 - 1.5e-24 86.9 1.8 2e-24 86.4 1.8 1.1 1 0 0 1 1 1 1 Formin Homology 2 Domain Phage_HK97_TLTM PF06120.11 ETO28385.1 - 0.00079 18.7 3.3 0.0011 18.3 3.3 1.1 1 0 0 1 1 1 1 Tail length tape measure protein PhaP_Bmeg PF09602.10 ETO28385.1 - 0.0016 18.4 0.7 0.0048 16.8 0.2 1.8 1 1 1 2 2 2 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) Spc7 PF08317.11 ETO28385.1 - 0.0041 16.0 0.6 0.0052 15.7 0.6 1.1 1 0 0 1 1 1 1 Spc7 kinetochore protein EzrA PF06160.12 ETO28385.1 - 0.0047 15.2 3.2 0.0059 14.8 3.2 1.0 1 0 0 1 1 1 1 Septation ring formation regulator, EzrA RmuC PF02646.16 ETO28385.1 - 0.01 15.0 0.8 0.015 14.4 0.8 1.2 1 0 0 1 1 1 0 RmuC family Muted PF14942.6 ETO28385.1 - 0.031 14.6 1.2 0.047 14.0 1.2 1.3 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein IFT57 PF10498.9 ETO28385.1 - 0.038 12.9 0.8 0.05 12.6 0.8 1.1 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 DUF948 PF06103.11 ETO28385.1 - 0.041 14.2 0.3 0.083 13.2 0.3 1.5 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Ubiq_cyt_C_chap PF03981.12 ETO28385.1 - 0.044 13.9 0.1 0.056 13.5 0.1 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome C chaperone Bacillus_HBL PF05791.11 ETO28385.1 - 0.047 13.5 1.1 0.069 13.0 1.1 1.3 1 0 0 1 1 1 0 Bacillus haemolytic enterotoxin (HBL) COG2 PF06148.11 ETO28385.1 - 0.071 13.2 1.1 0.15 12.1 1.1 1.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 DUF1825 PF08855.10 ETO28385.1 - 0.099 12.6 1.8 0.33 10.9 1.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF1825) DUF883 PF05957.13 ETO28385.1 - 0.11 13.1 0.9 0.24 12.0 0.9 1.6 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) PHM7_cyt PF14703.6 ETO28385.1 - 0.14 12.4 0.4 0.21 11.8 0.4 1.3 1 0 0 1 1 1 0 Cytosolic domain of 10TM putative phosphate transporter Lambda_CIII PF02061.16 ETO28385.1 - 0.15 12.1 0.1 0.32 11.1 0.1 1.5 1 0 0 1 1 1 0 Lambda Phage CIII DUF1664 PF07889.12 ETO28385.1 - 0.16 12.0 1.0 0.35 10.9 0.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) TMPIT PF07851.13 ETO28385.1 - 0.24 10.6 0.6 0.36 10.0 0.6 1.3 1 0 0 1 1 1 0 TMPIT-like protein RNA_pol_Rpb1_R PF05001.13 ETO28386.1 - 0.031 14.7 4.0 0.031 14.7 4.0 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat Filo_glycop PF01611.16 ETO28386.1 - 0.15 11.0 6.4 0.16 10.9 6.4 1.0 1 0 0 1 1 1 0 Filovirus glycoprotein KH_1 PF00013.29 ETO28387.1 - 6e-06 26.0 4.5 0.4 10.6 0.1 4.6 4 1 0 4 4 4 3 KH domain EF-hand_1 PF00036.32 ETO28388.1 - 2.7e-14 51.6 5.5 6.9e-07 28.4 0.5 3.9 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ETO28388.1 - 9.7e-11 40.7 6.4 3.2e-06 26.6 0.2 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_7 PF13499.6 ETO28388.1 - 1.2e-10 41.6 5.5 7.9e-06 26.2 2.2 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ETO28388.1 - 8.2e-07 28.8 4.4 0.095 12.6 0.0 3.6 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO28388.1 - 2.8e-05 23.4 0.9 2.8e-05 23.4 0.9 3.4 3 0 0 3 3 3 1 EF hand EF-hand_4 PF12763.7 ETO28388.1 - 0.00097 19.1 4.3 0.018 15.0 0.1 2.7 1 1 0 2 2 2 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO28388.1 - 0.013 15.9 0.8 0.051 13.9 0.2 2.0 1 1 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region DUF508 PF04370.12 ETO28389.1 - 0.1 12.3 0.3 0.19 11.4 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF508) Imm26 PF15428.6 ETO28389.1 - 0.16 12.2 0.0 0.39 11.0 0.0 1.6 1 0 0 1 1 1 0 Immunity protein 26 WD40 PF00400.32 ETO28390.1 - 4.1e-27 93.9 22.9 3.1e-06 27.8 1.7 6.3 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28390.1 - 1.4e-05 25.3 1.8 1 9.7 0.1 3.9 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ETO28390.1 - 0.033 13.8 0.1 0.75 9.3 0.1 2.7 2 1 0 2 2 2 0 PQQ-like domain CAP_GLY PF01302.25 ETO28392.1 - 1.1e-33 115.0 2.8 2.5e-16 59.5 0.2 2.3 2 0 0 2 2 2 2 CAP-Gly domain Pkinase PF00069.25 ETO28392.1 - 0.00017 21.1 0.5 0.00038 19.9 0.5 1.5 1 0 0 1 1 1 1 Protein kinase domain Striatin PF08232.12 ETO28392.1 - 0.017 15.7 3.4 0.029 14.9 3.4 1.3 1 0 0 1 1 1 0 Striatin family Pkinase_Tyr PF07714.17 ETO28392.1 - 0.047 13.0 0.2 0.081 12.2 0.2 1.3 1 0 0 1 1 1 0 Protein tyrosine kinase RabGAP-TBC PF00566.18 ETO28392.1 - 0.13 11.9 4.2 0.24 11.0 4.2 1.4 1 0 0 1 1 1 0 Rab-GTPase-TBC domain MAJIN PF15077.6 ETO28392.1 - 0.34 10.7 4.2 0.57 9.9 4.2 1.3 1 0 0 1 1 1 0 Membrane-anchored junction protein Adeno_PV PF03910.13 ETO28392.1 - 0.63 8.7 4.4 0.85 8.3 4.4 1.2 1 0 0 1 1 1 0 Adenovirus minor core protein PV Pkinase PF00069.25 ETO28393.1 - 2.5e-45 154.9 0.2 1.4e-42 145.9 0.2 2.4 1 1 0 1 1 1 1 Protein kinase domain EF-hand_1 PF00036.32 ETO28393.1 - 2.1e-22 76.9 8.2 9.7e-06 24.8 0.3 4.6 4 0 0 4 4 4 4 EF hand Pkinase_Tyr PF07714.17 ETO28393.1 - 5.3e-22 78.3 0.0 9.5e-22 77.5 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_7 PF13499.6 ETO28393.1 - 2.7e-19 69.4 17.8 3.7e-10 40.1 1.9 4.1 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO28393.1 - 9.8e-19 66.0 9.5 3.5e-06 26.3 0.4 4.6 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO28393.1 - 3.4e-17 60.8 10.5 1.3e-05 24.7 0.3 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_8 PF13833.6 ETO28393.1 - 7.5e-11 41.7 7.7 0.0086 15.9 0.0 4.7 2 1 2 4 4 4 4 EF-hand domain pair EF-hand_4 PF12763.7 ETO28393.1 - 3.3e-07 30.2 3.6 0.018 14.9 1.0 2.7 1 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand Kdo PF06293.14 ETO28393.1 - 0.034 13.5 0.1 0.086 12.2 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family SPARC_Ca_bdg PF10591.9 ETO28393.1 - 0.56 10.5 14.6 0.65 10.3 2.3 3.4 3 2 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_14 PF17959.1 ETO28393.1 - 0.77 10.1 4.6 1.5 9.3 0.9 3.1 1 1 2 3 3 3 0 EF-hand domain zf-CHY PF05495.12 ETO28394.1 - 3.7e-15 56.2 28.9 3.7e-15 56.2 28.9 4.0 2 1 0 2 2 2 1 CHY zinc finger zf-RING_2 PF13639.6 ETO28394.1 - 3.9e-07 30.3 9.3 3.9e-07 30.3 9.3 5.3 2 1 4 6 6 6 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO28394.1 - 8.5e-05 22.3 7.9 8.5e-05 22.3 7.9 5.9 3 2 4 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO28394.1 - 0.0009 19.1 5.9 0.0009 19.1 5.9 5.4 1 1 3 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO28394.1 - 0.0059 16.5 7.8 0.0059 16.5 7.8 5.4 1 1 2 3 3 3 1 zinc-RING finger domain Caskin-Pro-rich PF16907.5 ETO28394.1 - 2.5 8.7 6.8 0.24 12.0 0.4 2.5 3 0 0 3 3 3 0 Proline rich region of Caskin proteins DUF148 PF02520.17 ETO28395.1 - 0.00079 19.5 3.7 0.00079 19.5 3.7 2.7 3 0 0 3 3 3 1 Domain of unknown function DUF148 O-FucT PF10250.9 ETO28396.1 - 1.4e-18 67.8 4.0 4.5e-05 23.3 1.6 3.2 3 0 0 3 3 3 3 GDP-fucose protein O-fucosyltransferase Cyclin_N PF00134.23 ETO28397.1 - 2.5e-39 133.9 0.1 6.8e-39 132.5 0.1 1.8 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO28397.1 - 1e-13 51.4 2.1 1e-13 51.4 2.1 1.8 2 0 0 2 2 2 1 Cyclin, C-terminal domain CNV-Replicase_N PF16688.5 ETO28397.1 - 0.042 14.2 0.0 0.11 12.9 0.0 1.6 1 0 0 1 1 1 0 Replicase polyprotein N-term from Coronavirus nsp1 Pox_Ag35 PF03286.14 ETO28399.1 - 0.0059 16.4 8.7 0.0059 16.4 8.7 2.3 2 0 0 2 2 2 1 Pox virus Ag35 surface protein DUF883 PF05957.13 ETO28401.1 - 0.018 15.6 0.1 0.15 12.7 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Pox_A_type_inc PF04508.12 ETO28401.1 - 0.023 14.6 0.1 0.091 12.6 0.1 2.1 1 0 0 1 1 1 0 Viral A-type inclusion protein repeat NYD-SP28 PF14772.6 ETO28401.1 - 0.13 12.3 5.9 1.8 8.6 0.6 2.6 2 0 0 2 2 2 0 Sperm tail LXG PF04740.12 ETO28401.1 - 3.4 7.3 11.3 0.049 13.3 1.4 2.6 3 0 0 3 3 3 0 LXG domain of WXG superfamily MDFI PF15316.6 ETO28402.1 - 0.88 9.6 3.5 2.6 8.1 0.1 2.1 2 0 0 2 2 2 0 MyoD family inhibitor Peptidase_C65 PF10275.9 ETO28404.1 - 0.011 15.2 5.9 0.012 15.1 5.9 1.1 1 0 0 1 1 1 0 Peptidase C65 Otubain PhoLip_ATPase_N PF16209.5 ETO28404.1 - 0.073 12.8 3.2 0.2 11.4 3.2 1.9 1 1 0 1 1 1 0 Phospholipid-translocating ATPase N-terminal Pox_Ag35 PF03286.14 ETO28404.1 - 0.15 11.8 5.6 0.18 11.6 5.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SIR2 PF02146.17 ETO28404.1 - 0.21 11.5 3.3 0.29 11.0 3.3 1.3 1 0 0 1 1 1 0 Sir2 family LRR_4 PF12799.7 ETO28406.1 - 1e-07 32.2 18.2 0.017 15.5 2.9 5.3 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO28406.1 - 1.6e-07 30.9 18.3 6.7e-06 25.8 2.0 4.5 4 1 0 5 5 5 2 Leucine rich repeat LRR_9 PF14580.6 ETO28406.1 - 5e-06 26.1 7.9 0.0021 17.6 0.6 3.2 3 0 0 3 3 3 2 Leucine-rich repeat LRR_6 PF13516.6 ETO28406.1 - 0.018 15.1 12.1 5 7.4 0.2 6.0 6 0 0 6 6 6 0 Leucine Rich repeat Alpha_kinase PF02816.18 ETO28407.1 - 1.1e-11 45.2 0.7 1.3e-11 45.0 0.7 1.1 1 0 0 1 1 1 1 Alpha-kinase family LAGLIDADG_1 PF00961.19 ETO28407.1 - 0.17 12.9 2.6 0.26 12.3 2.6 1.3 1 0 0 1 1 1 0 LAGLIDADG endonuclease MMU163 PF17119.5 ETO28408.1 - 0.033 13.4 2.5 0.048 12.8 2.5 1.2 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Peptidase_S9 PF00326.21 ETO28409.1 - 2.9e-05 23.6 0.0 3.8e-05 23.2 0.0 1.3 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF829 PF05705.14 ETO28409.1 - 0.037 13.9 0.2 0.057 13.3 0.2 1.3 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF829) Hydrolase_4 PF12146.8 ETO28409.1 - 0.039 13.2 0.0 0.069 12.4 0.0 1.5 1 0 0 1 1 1 0 Serine aminopeptidase, S33 Abhydrolase_2 PF02230.16 ETO28409.1 - 0.097 12.5 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase Peptidase_C54 PF03416.19 ETO28410.1 - 2.6e-78 263.2 0.9 2.6e-78 263.2 0.9 1.5 2 0 0 2 2 2 1 Peptidase family C54 Peptidase_C78 PF07910.13 ETO28410.1 - 0.0058 16.1 0.1 0.011 15.2 0.1 1.4 1 0 0 1 1 1 1 Peptidase family C78 DUF45 PF01863.17 ETO28410.1 - 0.083 12.9 1.5 0.13 12.3 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function DUF45 DUF4604 PF15377.6 ETO28410.1 - 0.15 12.5 9.1 1 9.8 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) Anophelin PF10731.9 ETO28410.1 - 0.49 10.3 2.4 1 9.2 0.3 2.6 3 0 0 3 3 3 0 Thrombin inhibitor from mosquito FAM176 PF14851.6 ETO28410.1 - 4.8 6.8 10.5 2.1 8.0 1.5 2.6 3 0 0 3 3 3 0 FAM176 family Guanylate_cyc PF00211.20 ETO28411.1 - 4.5e-10 39.5 0.0 1.1e-06 28.4 0.0 2.1 2 0 0 2 2 2 2 Adenylate and Guanylate cyclase catalytic domain AAA_16 PF13191.6 ETO28412.1 - 1.4e-06 28.8 0.0 2.1e-06 28.2 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain Guanylate_cyc PF00211.20 ETO28412.1 - 4.3e-06 26.5 0.0 7.6e-06 25.7 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain NACHT PF05729.12 ETO28412.1 - 0.025 14.5 0.0 0.041 13.8 0.0 1.5 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 ETO28412.1 - 0.067 13.1 0.0 0.091 12.7 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase DUF2075 PF09848.9 ETO28412.1 - 0.085 12.1 0.0 0.11 11.7 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) DUF815 PF05673.13 ETO28412.1 - 0.12 11.5 0.0 0.17 11.0 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF815) NB-ARC PF00931.22 ETO28412.1 - 0.15 11.3 0.4 0.25 10.5 0.1 1.5 2 0 0 2 2 2 0 NB-ARC domain Creatininase PF02633.14 ETO28412.1 - 0.16 11.4 0.0 0.21 11.0 0.0 1.1 1 0 0 1 1 1 0 Creatinine amidohydrolase PH_17 PF18012.1 ETO28412.1 - 0.17 11.7 0.0 0.3 10.8 0.0 1.3 1 0 0 1 1 1 0 PH domain AAA_16 PF13191.6 ETO28413.1 - 6.7e-05 23.3 0.1 0.00017 22.0 0.1 1.7 1 0 0 1 1 1 1 AAA ATPase domain PI-PLC-X PF00388.19 ETO28414.1 - 0.012 15.2 0.0 0.022 14.4 0.0 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-specific phospholipase C, X domain DUF2203 PF09969.9 ETO28414.1 - 1.3 9.7 4.9 9.8 6.9 0.0 2.9 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) UDG PF03167.19 ETO28416.1 - 0.026 14.5 0.0 0.052 13.5 0.0 1.4 1 0 0 1 1 1 0 Uracil DNA glycosylase superfamily Cyclin_N PF00134.23 ETO28417.1 - 0.00027 20.7 0.0 0.00052 19.8 0.0 1.4 1 0 0 1 1 1 1 Cyclin, N-terminal domain Cyclin_N PF00134.23 ETO28418.1 - 0.00071 19.3 0.1 0.0022 17.8 0.0 1.8 2 0 0 2 2 2 1 Cyclin, N-terminal domain EF-hand_7 PF13499.6 ETO28419.1 - 3.2e-23 82.0 7.4 9.1e-13 48.5 1.0 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO28419.1 - 1.1e-22 77.8 12.9 4.3e-06 25.9 1.5 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO28419.1 - 4.2e-18 64.9 5.0 1.4e-10 40.9 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO28419.1 - 5.8e-18 63.2 8.0 1.2e-05 24.9 0.1 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_9 PF14658.6 ETO28419.1 - 2.5e-09 37.3 0.1 3.6e-08 33.6 0.1 2.2 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ETO28419.1 - 3.3e-09 35.8 11.4 0.0022 17.4 1.2 4.6 4 0 0 4 4 4 3 EF hand SPARC_Ca_bdg PF10591.9 ETO28419.1 - 1.3e-05 25.5 4.6 0.0002 21.7 1.0 2.4 2 1 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region DUF5580 PF17743.1 ETO28419.1 - 0.021 13.4 0.7 0.024 13.2 0.7 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) EF-hand_14 PF17959.1 ETO28419.1 - 0.031 14.6 3.8 1.5 9.2 0.4 2.7 1 1 1 2 2 2 0 EF-hand domain Beta-lactamase2 PF13354.6 ETO28419.1 - 0.092 12.3 0.1 0.18 11.4 0.1 1.4 1 1 0 1 1 1 0 Beta-lactamase enzyme family UPF0154 PF03672.13 ETO28419.1 - 0.12 12.4 0.2 7.7 6.6 0.0 2.6 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0154) Spond_N PF06468.13 ETO28420.1 - 0.041 14.0 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Spondin_N WD40 PF00400.32 ETO28421.1 - 6.7e-24 83.7 23.0 5.2e-05 23.9 1.2 6.1 6 0 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO28421.1 - 1.4e-06 27.3 6.3 0.75 8.4 0.0 4.3 2 2 2 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO28421.1 - 5.9e-06 26.9 1.8 5.9e-06 26.9 1.8 3.1 3 1 1 4 4 4 1 TRAF-type zinc finger ANAPC4_WD40 PF12894.7 ETO28421.1 - 0.0002 21.6 2.6 0.24 11.7 0.1 4.5 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain FAM76 PF16046.5 ETO28421.1 - 0.00082 18.8 25.7 0.0022 17.4 25.7 1.7 1 0 0 1 1 1 1 FAM76 protein Nmad5 PF18757.1 ETO28421.1 - 0.052 13.8 0.5 0.052 13.8 0.5 2.7 1 1 1 2 2 2 0 Nucleotide modification associated domain 5 Golgin_A5 PF09787.9 ETO28421.1 - 0.14 11.6 28.5 0.24 10.8 28.5 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF4407 PF14362.6 ETO28421.1 - 0.78 9.0 14.8 1.2 8.4 14.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) zf-C3HC4_2 PF13923.6 ETO28421.1 - 0.97 9.3 5.8 7.3 6.5 5.8 2.7 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF641 PF04859.12 ETO28421.1 - 6.4 7.1 25.9 2.3 8.6 5.3 3.6 1 1 2 3 3 3 0 Plant protein of unknown function (DUF641) TPR_2 PF07719.17 ETO28422.1 - 3.3e-18 64.2 22.8 2.6e-05 24.0 1.2 8.0 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28422.1 - 1.6e-17 62.5 23.2 1.3e-07 31.1 1.9 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28422.1 - 6.1e-16 57.2 11.6 0.00073 19.6 0.5 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO28422.1 - 7.8e-16 58.1 20.6 2.1e-08 34.2 1.6 5.4 4 1 1 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO28422.1 - 2.4e-15 56.8 0.6 0.0059 17.1 0.4 6.3 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28422.1 - 3.8e-12 46.3 7.3 7.9e-05 22.9 0.8 4.8 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO28422.1 - 5.5e-12 46.1 0.1 4.7e-07 30.3 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28422.1 - 6e-10 38.6 1.2 0.0011 18.6 0.0 4.7 3 1 1 4 4 4 2 TPR repeat TPR_6 PF13174.6 ETO28422.1 - 8e-10 38.7 9.6 0.0014 19.1 0.0 6.9 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO28422.1 - 2.2e-09 37.4 2.9 0.0077 17.0 0.0 6.2 5 1 1 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO28422.1 - 9.9e-06 25.6 4.9 0.001 19.3 0.1 5.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28422.1 - 2.3e-05 24.1 9.0 2.6 8.3 0.0 5.8 5 0 0 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO28422.1 - 0.0018 17.7 0.1 0.014 14.8 0.0 2.6 3 0 0 3 3 3 1 SHNi-TPR TPR_10 PF13374.6 ETO28422.1 - 0.0066 16.3 2.4 6.2 6.8 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat FAM60A PF15396.6 ETO28422.1 - 0.013 15.5 4.9 0.027 14.5 4.9 1.4 1 0 0 1 1 1 0 Protein Family FAM60A TPR_20 PF14561.6 ETO28422.1 - 0.034 14.5 0.1 2.2 8.7 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat Zip PF02535.22 ETO28422.1 - 0.14 11.4 0.2 0.21 10.8 0.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Sporozoite_P67 PF05642.11 ETO28422.1 - 0.32 9.0 6.2 0.5 8.4 6.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ALMT PF11744.8 ETO28422.1 - 0.38 9.5 2.8 0.6 8.9 2.8 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter NOA36 PF06524.12 ETO28422.1 - 4 6.7 13.5 6.8 5.9 13.5 1.3 1 0 0 1 1 1 0 NOA36 protein RP-C_C PF11800.8 ETO28422.1 - 7.7 6.5 5.8 14 5.7 5.8 1.4 1 1 0 1 1 1 0 Replication protein C C-terminal region DUF3987 PF13148.6 ETO28423.1 - 0.0014 17.7 0.8 0.0019 17.3 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3987) DUF1287 PF06940.11 ETO28423.1 - 0.027 14.1 0.1 0.034 13.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1287) YcgR_2 PF12945.7 ETO28423.1 - 0.074 13.2 0.3 0.16 12.1 0.2 1.7 2 0 0 2 2 2 0 Flagellar protein YcgR DUF4706 PF15797.5 ETO28423.1 - 1.6 9.3 6.5 2.9 8.5 6.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4706) Iso_dh PF00180.20 ETO28425.1 - 9.1e-75 252.0 0.0 1.7e-74 251.1 0.0 1.4 1 1 0 1 1 1 1 Isocitrate/isopropylmalate dehydrogenase DUF3367 PF11847.8 ETO28426.1 - 3 5.6 4.5 3.5 5.4 1.3 1.9 2 0 0 2 2 2 0 Alpha-(1->3)-arabinofuranosyltransferase TraI_2_C PF07515.11 ETO28427.1 - 0.026 14.5 0.1 0.048 13.6 0.1 1.5 1 0 0 1 1 1 0 Putative conjugal transfer nickase/helicase TraI C-term SET PF00856.28 ETO28428.1 - 1.6e-17 64.5 1.5 6.3e-17 62.5 0.5 2.2 2 1 0 2 2 2 1 SET domain Pex2_Pex12 PF04757.14 ETO28429.1 - 1.1e-24 87.3 1.1 1.6e-24 86.7 1.1 1.3 1 0 0 1 1 1 1 Pex2 / Pex12 amino terminal region zf-C3HC4 PF00097.25 ETO28429.1 - 0.0019 18.0 12.7 0.0034 17.2 12.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-HC5HC2H PF13771.6 ETO28429.1 - 0.0094 16.2 4.7 0.017 15.4 4.7 1.4 1 0 0 1 1 1 1 PHD-like zinc-binding domain zf-RING_2 PF13639.6 ETO28429.1 - 0.087 13.2 14.3 0.15 12.4 14.3 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4_4 PF15227.6 ETO28429.1 - 0.17 12.1 11.5 0.55 10.4 11.5 1.9 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ETO28429.1 - 0.17 12.0 12.3 0.34 11.0 12.3 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 ETO28429.1 - 0.19 11.8 6.7 0.29 11.2 4.7 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ETO28429.1 - 0.35 10.7 12.6 0.7 9.8 12.6 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO28429.1 - 0.82 9.7 11.0 1.5 8.8 11.0 1.5 1 0 0 1 1 1 0 zinc-RING finger domain DENN PF02141.21 ETO28430.1 - 8.9e-20 71.4 0.6 8.9e-20 71.4 0.6 2.2 2 0 0 2 2 2 1 DENN (AEX-3) domain Pkinase PF00069.25 ETO28432.1 - 8.8e-08 31.8 1.6 0.0052 16.2 0.2 2.7 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28432.1 - 3.7e-06 26.4 6.3 4.1e-05 23.0 0.5 2.7 3 0 0 3 3 3 2 Protein tyrosine kinase DBP10CT PF08147.12 ETO28432.1 - 0.025 14.8 0.1 0.28 11.5 0.1 2.7 2 0 0 2 2 2 0 DBP10CT (NUC160) domain Pkinase_Tyr PF07714.17 ETO28433.1 - 1.8e-11 43.8 0.5 3.3e-10 39.7 0.4 2.6 2 1 0 2 2 2 1 Protein tyrosine kinase Pkinase PF00069.25 ETO28433.1 - 1.3e-09 37.9 0.0 9.7e-07 28.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain GST_N PF02798.20 ETO28434.1 - 6.1e-14 52.1 0.0 1.3e-13 51.0 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C_3 PF14497.6 ETO28434.1 - 4.4e-11 42.9 0.0 7.8e-11 42.0 0.0 1.4 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_C PF00043.25 ETO28434.1 - 0.00025 21.2 0.0 0.00055 20.1 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, C-terminal domain GST_N_3 PF13417.6 ETO28434.1 - 0.008 16.6 0.0 0.018 15.4 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain DUF2181 PF10223.9 ETO28434.1 - 0.063 12.7 0.0 0.12 11.8 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2181) GST_C_2 PF13410.6 ETO28434.1 - 0.1 12.6 0.0 0.2 11.7 0.0 1.4 1 0 0 1 1 1 0 Glutathione S-transferase, C-terminal domain ALMT PF11744.8 ETO28435.1 - 6.6 5.5 7.9 5.2 5.8 7.0 1.3 1 1 0 1 1 1 0 Aluminium activated malate transporter EMC3_TMCO1 PF01956.16 ETO28436.1 - 0.15 11.8 0.0 0.15 11.8 0.0 4.4 1 1 1 3 3 3 0 Integral membrane protein EMC3/TMCO1-like Menin PF05053.13 ETO28437.1 - 0.52 8.6 7.2 0.65 8.3 7.2 1.1 1 0 0 1 1 1 0 Menin GREB1 PF15782.5 ETO28437.1 - 1 6.4 4.3 1.1 6.2 4.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SSP160 PF06933.11 ETO28437.1 - 1.4 7.1 10.5 1.6 6.8 10.5 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Macoilin PF09726.9 ETO28437.1 - 7.7 4.9 7.4 7 5.1 7.4 1.1 1 0 0 1 1 1 0 Macoilin family DAGK_cat PF00781.24 ETO28438.1 - 2e-12 46.8 0.0 4.8e-12 45.6 0.0 1.6 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain G-alpha PF00503.20 ETO28439.1 - 9.1e-37 127.0 15.7 9.1e-37 127.0 15.7 1.9 1 1 1 2 2 2 1 G-protein alpha subunit MMR_HSR1 PF01926.23 ETO28439.1 - 0.0016 18.5 0.0 0.02 15.0 0.0 2.6 2 0 0 2 2 2 1 50S ribosome-binding GTPase Arf PF00025.21 ETO28439.1 - 0.0038 16.7 0.4 0.011 15.2 0.2 1.8 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO28439.1 - 0.0078 15.8 0.0 0.33 10.5 0.0 2.7 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain FeoB_N PF02421.18 ETO28439.1 - 0.024 14.2 0.1 0.057 13.0 0.1 1.6 1 0 0 1 1 1 0 Ferrous iron transport protein B Peptidase_S49_N PF08496.10 ETO28439.1 - 0.044 13.8 14.6 0.62 10.1 7.0 3.6 3 0 0 3 3 3 0 Peptidase family S49 N-terminal ABC_tran PF00005.27 ETO28440.1 - 5.4e-24 85.3 0.0 7.9e-24 84.7 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ETO28440.1 - 0.0052 17.3 0.1 0.0085 16.6 0.1 1.4 1 0 0 1 1 1 1 AAA domain SRP54 PF00448.22 ETO28440.1 - 0.013 15.1 0.1 0.02 14.6 0.1 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 ETO28440.1 - 0.11 12.2 0.2 0.26 11.1 0.2 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain RsgA_GTPase PF03193.16 ETO28440.1 - 0.13 12.1 0.1 0.2 11.5 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_21 PF13304.6 ETO28440.1 - 0.17 11.7 0.9 0.46 10.3 0.3 1.9 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_30 PF13604.6 ETO28440.1 - 0.17 11.6 0.0 0.26 11.0 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_15 PF13175.6 ETO28440.1 - 0.19 11.4 0.0 0.28 10.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Glyco_hydro_38N PF01074.22 ETO28441.1 - 0.0015 18.0 0.7 0.0017 17.8 0.7 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain LMBR1 PF04791.16 ETO28441.1 - 0.017 14.1 1.8 0.019 13.9 1.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein ABC2_membrane_3 PF12698.7 ETO28442.1 - 5.7e-29 101.3 17.1 9e-29 100.7 17.1 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein ABC_tran PF00005.27 ETO28442.1 - 1.3e-22 80.8 0.0 2.2e-22 80.1 0.0 1.4 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO28442.1 - 6.6e-10 39.3 0.0 5.2e-07 29.8 0.0 2.4 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system SMC_N PF02463.19 ETO28442.1 - 0.013 14.9 0.0 0.022 14.2 0.0 1.5 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO28442.1 - 0.13 12.5 0.0 1 9.6 0.0 2.4 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit SRP54 PF00448.22 ETO28442.1 - 0.13 11.8 0.2 0.23 11.0 0.2 1.3 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain WD40 PF00400.32 ETO28443.1 - 1.8e-30 104.5 20.9 1.4e-06 28.9 1.3 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28443.1 - 1.5e-07 31.6 0.1 0.048 14.0 0.0 3.5 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28443.1 - 0.00011 21.3 1.9 0.012 14.6 1.8 2.8 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NHL PF01436.21 ETO28443.1 - 0.39 10.8 2.7 1.8 8.7 0.1 3.2 3 0 0 3 3 3 0 NHL repeat Syntaxin-6_N PF09177.11 ETO28444.1 - 9.8e-15 54.9 1.1 9.8e-15 54.9 1.1 2.7 2 1 0 2 2 2 1 Syntaxin 6, N-terminal Use1 PF09753.9 ETO28444.1 - 2.5e-06 27.4 15.8 3.1e-06 27.1 15.8 1.1 1 0 0 1 1 1 1 Membrane fusion protein Use1 ALMT PF11744.8 ETO28444.1 - 0.0044 15.9 11.3 0.0055 15.6 11.3 1.2 1 0 0 1 1 1 1 Aluminium activated malate transporter UPF0184 PF03670.13 ETO28444.1 - 0.016 15.6 0.9 0.016 15.6 0.9 2.9 1 1 1 3 3 3 0 Uncharacterised protein family (UPF0184) Laminin_II PF06009.12 ETO28444.1 - 0.032 14.3 15.3 0.32 11.0 2.0 3.3 1 1 3 4 4 4 0 Laminin Domain II KxDL PF10241.9 ETO28444.1 - 0.036 14.4 0.9 0.036 14.4 0.9 3.7 1 1 3 4 4 4 0 Uncharacterized conserved protein SNARE PF05739.19 ETO28444.1 - 0.036 14.1 9.8 0.23 11.5 7.3 3.0 2 1 0 2 2 2 0 SNARE domain ApoO PF09769.9 ETO28444.1 - 0.05 13.6 1.2 2.6 8.0 0.4 2.7 2 1 0 2 2 2 0 Apolipoprotein O ApoLp-III PF07464.11 ETO28444.1 - 0.17 12.0 15.6 0.016 15.3 7.5 2.7 1 1 1 2 2 2 0 Apolipophorin-III precursor (apoLp-III) Syntaxin PF00804.25 ETO28444.1 - 0.19 11.4 18.8 1.7 8.2 10.4 2.8 1 1 1 2 2 2 0 Syntaxin DUF4298 PF14131.6 ETO28444.1 - 0.24 11.4 6.7 0.49 10.4 0.1 3.6 2 1 2 4 4 4 0 Domain of unknown function (DUF4298) DUF948 PF06103.11 ETO28444.1 - 0.31 11.3 15.0 12 6.3 0.4 4.2 1 1 1 2 2 1 0 Bacterial protein of unknown function (DUF948) DUF2203 PF09969.9 ETO28444.1 - 0.43 11.3 14.6 2.9 8.6 0.4 3.1 1 1 2 3 3 3 0 Uncharacterized conserved protein (DUF2203) PIN_8 PF18476.1 ETO28444.1 - 0.46 10.3 16.4 0.055 13.3 6.2 2.2 1 1 1 2 2 2 0 PIN like domain OmpH PF03938.14 ETO28444.1 - 0.86 9.9 21.4 2.3e+03 -1.2 21.1 2.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) FapA PF03961.13 ETO28444.1 - 0.97 8.0 16.5 1.5 7.3 2.0 2.1 1 1 2 3 3 3 0 Flagellar Assembly Protein A DUF2937 PF11157.8 ETO28444.1 - 1.5 8.5 5.5 0.58 9.9 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2937) ETRAMP PF09716.10 ETO28444.1 - 1.6 8.8 5.3 3.8 7.6 1.0 2.7 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) UPF0242 PF06785.11 ETO28444.1 - 1.8 8.6 25.7 0.97 9.5 3.7 2.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus FUSC PF04632.12 ETO28444.1 - 2 6.9 4.7 13 4.1 0.2 2.0 1 1 1 2 2 2 0 Fusaric acid resistance protein family DUF3452 PF11934.8 ETO28444.1 - 2 8.0 7.7 35 3.9 7.7 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3452) Exonuc_VII_S PF02609.16 ETO28444.1 - 2.5 8.2 0.0 2.5 8.2 0.0 3.7 4 1 1 5 5 4 0 Exonuclease VII small subunit Mt_ATP-synt_D PF05873.12 ETO28444.1 - 2.5 7.9 15.3 0.21 11.4 2.4 3.3 1 1 2 3 3 3 0 ATP synthase D chain, mitochondrial (ATP5H) ASPRs PF17641.2 ETO28444.1 - 2.8 8.3 7.3 6.5 7.1 0.4 2.7 2 2 0 2 2 2 0 Ancylostoma-associated secreted protein related IL11 PF07400.11 ETO28444.1 - 2.9 7.5 11.6 0.19 11.4 0.8 3.1 1 1 1 3 3 3 0 Interleukin 11 GrpE PF01025.19 ETO28444.1 - 3.1 7.4 12.8 15 5.2 10.0 2.6 1 1 1 2 2 2 0 GrpE YtxH PF12732.7 ETO28444.1 - 3.8 8.1 6.2 3.7e+02 1.7 6.2 3.4 1 1 0 1 1 1 0 YtxH-like protein Spore_III_AB PF09548.10 ETO28444.1 - 4.1 7.5 10.0 1.7 8.7 6.5 2.3 1 1 1 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) XRN_M PF17846.1 ETO28444.1 - 4.6 6.1 9.9 6.2 5.7 9.8 1.3 1 1 0 1 1 1 0 Xrn1 helical domain DUF883 PF05957.13 ETO28444.1 - 4.7 7.9 10.7 3.7 8.2 0.1 3.6 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) HSCB_C PF07743.13 ETO28444.1 - 6.7 7.3 12.5 1.2 9.7 0.3 3.8 1 1 1 2 2 1 0 HSCB C-terminal oligomerisation domain GAT PF03127.14 ETO28444.1 - 7.3 7.0 15.1 9.1 6.7 0.4 3.5 2 2 1 3 3 3 0 GAT domain HIP1_clath_bdg PF16515.5 ETO28444.1 - 8.8 7.0 22.8 3.7 8.2 4.1 3.3 1 1 1 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 TLD PF07534.16 ETO28445.1 - 6.4e-29 100.9 1.0 8.7e-29 100.5 0.1 1.7 2 0 0 2 2 2 1 TLD Menin PF05053.13 ETO28445.1 - 0.022 13.2 2.4 0.027 12.8 2.4 1.1 1 0 0 1 1 1 0 Menin FCH PF00611.23 ETO28445.1 - 1.1 9.6 4.9 1 9.7 3.2 1.9 2 1 0 2 2 2 0 Fes/CIP4, and EFC/F-BAR homology domain Prismane PF03063.20 ETO28446.1 - 4.4e-56 190.6 0.0 4.9e-56 190.5 0.0 1.0 1 0 0 1 1 1 1 Prismane/CO dehydrogenase family Prismane PF03063.20 ETO28447.1 - 9.6e-47 159.8 0.0 8.2e-32 110.6 0.0 2.1 2 0 0 2 2 2 2 Prismane/CO dehydrogenase family Exo_endo_phos PF03372.23 ETO28448.1 - 0.04 13.4 0.0 0.057 12.9 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family TLD PF07534.16 ETO28449.1 - 5.4e-11 42.9 1.4 9.8e-11 42.0 1.4 1.4 1 0 0 1 1 1 1 TLD fn3 PF00041.21 ETO28449.1 - 0.01 16.1 0.0 0.12 12.7 0.0 2.5 2 0 0 2 2 2 0 Fibronectin type III domain SDA1 PF05285.12 ETO28449.1 - 0.025 14.0 42.3 0.035 13.5 42.3 1.3 1 0 0 1 1 1 0 SDA1 CDC27 PF09507.10 ETO28449.1 - 0.16 11.3 37.6 0.22 10.9 37.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 DUF4481 PF14800.6 ETO28449.1 - 0.16 11.4 0.9 0.26 10.7 0.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4481) CDC45 PF02724.14 ETO28449.1 - 0.18 10.0 34.8 0.28 9.4 34.8 1.3 1 0 0 1 1 1 0 CDC45-like protein SOBP PF15279.6 ETO28449.1 - 1.2 9.7 5.2 1.7 9.2 5.2 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Apt1 PF10351.9 ETO28449.1 - 1.4 7.7 21.8 1.8 7.3 21.8 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Nop53 PF07767.11 ETO28449.1 - 1.6 8.1 35.5 0.72 9.2 33.3 1.5 1 1 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Mpp10 PF04006.12 ETO28449.1 - 7 5.0 40.1 11 4.3 40.1 1.2 1 0 0 1 1 1 0 Mpp10 protein Nop14 PF04147.12 ETO28449.1 - 7.6 4.6 45.1 11 4.1 45.1 1.2 1 0 0 1 1 1 0 Nop14-like family NAM-associated PF14303.6 ETO28449.1 - 8.3 7.1 37.2 0.17 12.6 30.7 1.6 2 0 0 2 2 1 0 No apical meristem-associated C-terminal domain BSP_II PF05432.11 ETO28449.1 - 8.7 5.9 32.3 13 5.3 32.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2615 PF11027.8 ETO28450.1 - 3.2e-05 24.0 4.5 0.00014 22.0 3.3 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF2615) Sigma_reg_N PF13800.6 ETO28450.1 - 0.00041 20.6 3.6 0.021 15.1 0.4 3.0 3 0 0 3 3 3 1 Sigma factor regulator N-terminal EphA2_TM PF14575.6 ETO28450.1 - 0.00052 20.8 0.3 0.029 15.2 0.0 2.8 2 1 1 3 3 3 1 Ephrin type-A receptor 2 transmembrane domain SARAF PF06682.12 ETO28450.1 - 0.0027 17.4 0.7 0.0056 16.4 0.7 1.5 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis TMEM154 PF15102.6 ETO28450.1 - 0.0061 16.5 12.9 0.0061 16.5 12.9 3.7 2 1 2 4 4 4 1 TMEM154 protein family DUF4834 PF16118.5 ETO28450.1 - 0.023 15.7 5.1 0.023 15.7 5.1 3.2 2 2 1 3 3 3 0 Domain of unknown function (DUF4834) DUF3671 PF12420.8 ETO28450.1 - 0.029 14.4 1.8 0.029 14.4 1.8 2.4 2 0 0 2 2 2 0 Protein of unknown function Oxidored_q3 PF00499.20 ETO28450.1 - 0.047 13.4 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 TMEM51 PF15345.6 ETO28450.1 - 0.14 11.9 1.8 0.28 11.0 1.8 1.4 1 0 0 1 1 1 0 Transmembrane protein 51 O-antigen_lig PF13425.6 ETO28450.1 - 0.15 10.8 11.8 0.13 11.1 8.6 2.1 2 0 0 2 2 2 0 O-antigen ligase like membrane protein DUF5385 PF17359.2 ETO28450.1 - 0.17 11.4 17.0 0.032 13.8 7.1 2.6 2 1 0 2 2 2 0 Family of unknown function (DUF5385) RIFIN PF02009.16 ETO28450.1 - 1.9 8.3 14.2 0.037 13.9 6.1 1.9 1 1 1 2 2 2 0 Rifin CSG2 PF16965.5 ETO28450.1 - 2.1 7.2 7.9 3.2 6.6 7.9 1.3 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 ETO28450.1 - 7.7 5.3 13.8 0.2 10.6 7.5 1.5 2 0 0 2 2 2 0 Serine incorporator (Serinc) PAH PF02671.21 ETO28451.1 - 0.071 13.3 1.1 0.071 13.3 1.1 2.3 2 0 0 2 2 2 0 Paired amphipathic helix repeat RSF PF14876.6 ETO28451.1 - 0.96 8.3 0.0 0.96 8.3 0.0 3.2 2 1 1 3 3 3 0 Respiratory growth transcriptional regulator MotB_plug PF13677.6 ETO28452.1 - 0.061 12.9 0.7 0.24 11.0 0.7 2.2 1 1 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB DUF241 PF03087.14 ETO28452.1 - 1.3 8.8 11.9 0.82 9.5 9.6 1.7 1 1 0 2 2 2 0 Arabidopsis protein of unknown function RAMP4 PF06624.12 ETO28452.1 - 8.9 6.5 9.7 1 9.4 1.7 2.8 3 0 0 3 3 3 0 Ribosome associated membrane protein RAMP4 Pkinase PF00069.25 ETO28453.1 - 9.3e-24 84.2 0.1 9.3e-24 84.2 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28453.1 - 1.9e-15 56.9 0.1 2.7e-15 56.4 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase DUF3937 PF13073.6 ETO28454.1 - 0.056 13.6 1.3 0.071 13.2 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) DNA_ligase_A_C PF04679.15 ETO28454.1 - 0.16 12.5 0.0 0.21 12.2 0.0 1.2 1 0 0 1 1 1 0 ATP dependent DNA ligase C terminal region Nop14 PF04147.12 ETO28455.1 - 0.029 12.6 25.3 0.036 12.3 25.3 1.1 1 0 0 1 1 1 0 Nop14-like family GET2 PF08690.10 ETO28455.1 - 0.1 12.3 15.5 0.16 11.6 15.5 1.3 1 0 0 1 1 1 0 GET complex subunit GET2 LAP1C PF05609.12 ETO28455.1 - 0.19 10.8 17.1 0.26 10.3 17.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Dapper PF15268.6 ETO28455.1 - 0.28 10.0 17.6 0.35 9.7 17.6 1.1 1 0 0 1 1 1 0 Dapper SDA1 PF05285.12 ETO28455.1 - 0.34 10.3 26.7 0.47 9.8 26.7 1.2 1 0 0 1 1 1 0 SDA1 Presenilin PF01080.17 ETO28455.1 - 1.1 7.9 24.1 2 7.1 24.1 1.5 1 0 0 1 1 1 0 Presenilin Utp14 PF04615.13 ETO28455.1 - 6.3 5.2 30.6 8.6 4.8 30.6 1.1 1 0 0 1 1 1 0 Utp14 protein GREB1 PF15782.5 ETO28455.1 - 8.8 3.3 17.1 10 3.1 17.1 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ERGIC_N PF13850.6 ETO28456.1 - 0.012 15.9 1.6 0.029 14.7 1.6 1.6 1 0 0 1 1 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) MFS_Mycoplasma PF07672.13 ETO28456.1 - 0.13 11.5 3.4 0.077 12.3 1.7 1.5 1 1 0 1 1 1 0 Mycoplasma MFS transporter TP2 PF01254.18 ETO28456.1 - 0.33 11.5 8.2 0.051 14.2 3.7 1.8 2 0 0 2 2 2 0 Nuclear transition protein 2 MBR1 PF17058.5 ETO28456.1 - 7 6.9 13.5 28 4.9 13.5 1.9 1 1 0 1 1 1 0 Mitochondrial biogenesis regulation protein 1 YqhR PF11085.8 ETO28458.1 - 0.34 10.8 10.8 0.38 10.7 10.8 1.1 1 0 0 1 1 1 0 Conserved membrane protein YqhR NAGLU_N PF12971.7 ETO28459.1 - 3.3e-12 46.0 0.7 4.3e-11 42.4 0.7 2.1 1 1 0 1 1 1 1 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain Peptidase_M56 PF05569.11 ETO28459.1 - 0.013 14.7 0.2 0.018 14.3 0.2 1.1 1 0 0 1 1 1 0 BlaR1 peptidase M56 WD40 PF00400.32 ETO28460.1 - 1.9e-09 38.0 0.6 0.0006 20.6 0.0 4.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28460.1 - 0.0004 20.6 0.2 11 6.4 0.0 4.2 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO28460.1 - 0.064 13.1 0.1 5.7 6.8 0.0 2.6 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF2671 PF10877.8 ETO28460.1 - 0.074 12.8 0.4 0.2 11.5 0.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2671) EOS1 PF12326.8 ETO28461.1 - 1.2 9.1 3.6 1.9 8.4 3.6 1.3 1 0 0 1 1 1 0 N-glycosylation protein CENP-B_dimeris PF09026.10 ETO28462.1 - 0.026 14.9 5.9 0.089 13.2 4.7 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Gmx_para_CXXCG PF09535.10 ETO28462.1 - 0.055 12.7 0.1 0.091 12.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (Gmx_para_CXXCG) Aminopep PF10023.9 ETO28462.1 - 0.071 12.5 4.0 2.1 7.6 0.0 2.1 1 1 1 2 2 2 0 Putative aminopeptidase RNA_pol_3_Rpc31 PF11705.8 ETO28462.1 - 0.33 11.2 18.3 0.78 9.9 18.3 1.6 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 CDC45 PF02724.14 ETO28462.1 - 0.88 7.8 10.4 0.93 7.7 10.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Orf78 PF06024.12 ETO28462.1 - 1 9.7 0.0 1 9.7 0.0 3.3 3 0 0 3 3 3 0 Orf78 (ac78) DNA_pol_phi PF04931.13 ETO28462.1 - 3.9 5.5 12.2 5.3 5.0 12.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi Pannexin_like PF12534.8 ETO28462.1 - 4.8 6.2 7.5 0.89 8.6 3.4 1.8 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 PBP1_TM PF14812.6 ETO28462.1 - 6.1 7.3 13.2 1.8 9.0 8.7 2.5 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal alpha-hel2 PF14456.6 ETO28463.1 - 0.00013 21.4 4.7 0.00016 21.1 4.7 1.1 1 0 0 1 1 1 1 Alpha-helical domain 2 Caldesmon PF02029.15 ETO28463.1 - 0.08 11.7 20.7 0.091 11.5 20.7 1.0 1 0 0 1 1 1 0 Caldesmon Bd3614-deam PF14439.6 ETO28463.1 - 0.29 11.2 2.8 0.44 10.6 2.8 1.2 1 0 0 1 1 1 0 Bd3614-like deaminase RasGEF_N PF00618.20 ETO28463.1 - 1.4 9.2 11.3 10 6.4 11.3 2.1 1 1 0 1 1 1 0 RasGEF N-terminal motif DUF4344 PF14247.6 ETO28464.1 - 0.023 14.4 0.1 0.048 13.3 0.1 1.5 1 0 0 1 1 1 0 Putative metallopeptidase WLM PF08325.10 ETO28464.1 - 0.067 13.3 0.0 0.28 11.2 0.0 1.9 2 0 0 2 2 2 0 WLM domain Peptidase_M50B PF13398.6 ETO28464.1 - 0.19 11.3 0.2 0.29 10.7 0.2 1.3 1 0 0 1 1 1 0 Peptidase M50B-like zf-C3HC4 PF00097.25 ETO28465.1 - 0.00031 20.5 6.1 0.00094 19.0 6.1 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO28465.1 - 0.00048 19.9 5.5 0.0015 18.3 5.5 1.9 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO28465.1 - 0.0013 19.0 5.7 0.0013 19.0 5.7 2.7 3 0 0 3 3 3 1 Ring finger domain DUF3246 PF11596.8 ETO28465.1 - 0.0093 15.4 1.5 0.017 14.6 1.5 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3246) zf-rbx1 PF12678.7 ETO28465.1 - 0.012 15.9 8.0 0.018 15.3 5.1 2.6 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-HC5HC2H PF13771.6 ETO28465.1 - 0.033 14.4 1.4 0.06 13.6 0.2 2.1 2 0 0 2 2 2 0 PHD-like zinc-binding domain Zn-ribbon_8 PF09723.10 ETO28465.1 - 0.19 11.9 3.5 0.34 11.1 1.0 2.4 2 0 0 2 2 2 0 Zinc ribbon domain Fibrillin_U_N PF18193.1 ETO28465.1 - 0.25 11.5 1.3 0.55 10.4 1.3 1.5 1 0 0 1 1 1 0 Fibrillin 1 unique N-terminal domain DZR PF12773.7 ETO28465.1 - 0.3 11.2 3.2 0.86 9.7 3.2 1.7 1 0 0 1 1 1 0 Double zinc ribbon zf-HC5HC2H_2 PF13832.6 ETO28465.1 - 3.2 8.0 7.0 1 9.6 0.6 2.7 3 0 0 3 3 3 0 PHD-zinc-finger like domain zf-RING_11 PF17123.5 ETO28465.1 - 7 6.5 8.6 0.33 10.8 1.7 2.4 2 0 0 2 2 2 0 RING-like zinc finger Vac14_Fig4_bd PF11916.8 ETO28469.1 - 6.3e-36 123.7 2.7 1e-35 123.0 2.7 1.3 1 0 0 1 1 1 1 Vacuolar protein 14 C-terminal Fig4p binding DUF1943 PF09172.11 ETO28470.1 - 0.0021 17.4 1.9 0.0035 16.6 1.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1943) TFIIA PF03153.13 ETO28470.1 - 5.5 6.9 22.9 6 6.8 22.9 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CCDC53 PF10152.9 ETO28471.1 - 2.1e-06 28.2 2.5 4.2e-06 27.2 2.5 1.5 1 1 0 1 1 1 1 Subunit CCDC53 of WASH complex DivIC PF04977.15 ETO28471.1 - 0.02 14.7 0.7 0.038 13.8 0.7 1.4 1 0 0 1 1 1 0 Septum formation initiator SlyX PF04102.12 ETO28471.1 - 0.024 15.2 0.3 0.048 14.3 0.3 1.5 1 0 0 1 1 1 0 SlyX Fungal_TACC PF12709.7 ETO28471.1 - 0.029 14.8 1.1 0.053 14.0 1.1 1.4 1 0 0 1 1 1 0 Fungal Transforming acidic coiled-coil (TACC) proteins DUF948 PF06103.11 ETO28471.1 - 0.078 13.3 1.0 0.17 12.2 0.1 1.8 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) bZIP_1 PF00170.21 ETO28471.1 - 0.19 11.8 1.2 0.33 11.1 1.2 1.3 1 0 0 1 1 1 0 bZIP transcription factor K_channel_TID PF07941.11 ETO28471.1 - 0.55 10.7 7.4 0.46 11.0 0.7 2.3 2 0 0 2 2 2 0 Potassium channel Kv1.4 tandem inactivation domain Menin PF05053.13 ETO28471.1 - 0.79 8.0 3.3 0.96 7.7 3.3 1.0 1 0 0 1 1 1 0 Menin Kinesin PF00225.23 ETO28472.1 - 2.3e-25 89.2 0.0 2.3e-25 89.2 0.0 6.4 3 2 1 4 4 4 1 Kinesin motor domain Phage_term_smal PF05944.12 ETO28473.1 - 0.039 13.9 0.1 0.087 12.8 0.1 1.5 1 0 0 1 1 1 0 Phage small terminase subunit PsbQ PF05757.11 ETO28473.1 - 0.076 12.7 0.2 0.14 11.9 0.2 1.4 1 0 0 1 1 1 0 Oxygen evolving enhancer protein 3 (PsbQ) PDZ_2 PF13180.6 ETO28474.1 - 2.7e-06 27.6 0.0 6.8e-06 26.3 0.0 1.6 1 0 0 1 1 1 1 PDZ domain PDZ_6 PF17820.1 ETO28474.1 - 3.4e-05 23.6 0.0 6.1e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ETO28474.1 - 0.0044 17.3 0.0 0.009 16.3 0.0 1.5 1 0 0 1 1 1 1 PDZ domain Secretin_N_2 PF07655.13 ETO28474.1 - 0.15 12.6 8.8 0.31 11.6 8.8 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain PARP PF00644.20 ETO28476.1 - 1.7e-07 31.0 1.9 4.2e-07 29.8 0.5 2.0 1 1 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain TF_Zn_Ribbon PF08271.12 ETO28476.1 - 0.0047 16.4 4.5 0.013 14.9 4.5 1.7 1 0 0 1 1 1 1 TFIIB zinc-binding IBR PF01485.21 ETO28476.1 - 1.9 8.8 12.0 0.38 11.0 8.1 1.9 2 0 0 2 2 2 0 IBR domain, a half RING-finger domain TRAM_LAG1_CLN8 PF03798.16 ETO28477.1 - 1.2e-24 87.2 29.4 1.2e-24 87.2 29.4 1.5 2 0 0 2 2 2 1 TLC domain Occludin_ELL PF07303.13 ETO28478.1 - 0.0036 18.0 3.4 0.0036 18.0 3.4 2.3 1 1 0 2 2 2 1 Occludin homology domain GAS PF13851.6 ETO28478.1 - 0.0053 16.1 10.8 0.0053 16.1 10.8 2.1 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Syntaxin_2 PF14523.6 ETO28478.1 - 0.011 16.1 6.4 0.011 16.1 6.4 2.2 1 1 2 3 3 3 0 Syntaxin-like protein FliD_N PF02465.18 ETO28478.1 - 0.017 15.8 6.1 0.017 15.8 6.1 2.3 2 2 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus GreA_GreB_N PF03449.15 ETO28478.1 - 0.022 14.9 3.4 0.071 13.3 1.8 2.6 2 1 1 3 3 3 0 Transcription elongation factor, N-terminal NYD-SP28_assoc PF14775.6 ETO28478.1 - 0.037 14.1 5.3 0.089 12.9 5.3 1.6 1 0 0 1 1 1 0 Sperm tail C-terminal domain PspB PF06667.12 ETO28478.1 - 0.17 12.0 1.3 0.82 9.8 1.3 2.1 1 1 0 1 1 1 0 Phage shock protein B DUF4298 PF14131.6 ETO28478.1 - 0.19 11.7 7.6 0.42 10.6 7.1 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4298) DivIC PF04977.15 ETO28478.1 - 0.4 10.5 7.5 0.14 11.9 3.3 2.4 1 1 0 1 1 1 0 Septum formation initiator DUF4407 PF14362.6 ETO28478.1 - 1.9 7.7 10.9 1.6 8.0 10.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Ly49 PF08391.10 ETO28478.1 - 3 8.2 13.9 0.043 14.2 3.3 2.3 1 1 1 2 2 2 0 Ly49-like protein, N-terminal region AAA_23 PF13476.6 ETO28478.1 - 3.2 8.2 14.7 5.8 7.4 14.7 1.4 1 0 0 1 1 1 0 AAA domain RecX PF02631.16 ETO28478.1 - 4 7.9 10.8 0.25 11.8 5.6 1.7 2 0 0 2 2 2 0 RecX family LMBR1 PF04791.16 ETO28478.1 - 5.5 5.8 10.3 6.1 5.6 10.3 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Chordopox_A13L PF05961.11 ETO28479.1 - 0.066 13.4 1.2 0.15 12.3 1.2 1.7 1 0 0 1 1 1 0 Chordopoxvirus A13L protein DUF1097 PF06496.11 ETO28479.1 - 0.12 12.5 0.0 0.17 12.0 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1097) ODV-E18 PF10717.9 ETO28479.1 - 0.16 11.8 1.2 0.29 11.0 1.2 1.4 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 ERM PF00769.19 ETO28480.1 - 1.8e-05 24.7 25.9 1.8e-05 24.7 25.9 3.4 5 0 0 5 5 5 1 Ezrin/radixin/moesin family Lebercilin PF15619.6 ETO28480.1 - 0.0089 15.7 33.2 0.0089 15.7 33.2 3.8 4 0 0 4 4 4 1 Ciliary protein causing Leber congenital amaurosis disease DUF2417 PF10329.9 ETO28480.1 - 0.03 13.7 0.7 0.059 12.8 0.1 1.8 2 0 0 2 2 2 0 Region of unknown function (DUF2417) TPR_MLP1_2 PF07926.12 ETO28480.1 - 5.3 7.1 60.0 0.74 9.9 7.9 5.4 4 2 0 4 4 4 0 TPR/MLP1/MLP2-like protein Peptidase_S9 PF00326.21 ETO28481.1 - 0.0011 18.4 1.1 0.076 12.5 0.0 3.5 2 1 2 4 4 4 1 Prolyl oligopeptidase family Abhydrolase_2 PF02230.16 ETO28481.1 - 0.033 14.0 0.1 0.072 12.9 0.1 1.5 1 0 0 1 1 1 0 Phospholipase/Carboxylesterase GAPT PF11770.8 ETO28481.1 - 3 7.7 12.8 0.066 13.1 3.5 2.3 2 1 0 2 2 2 0 GRB2-binding adapter (GAPT) AhpC-TSA PF00578.21 ETO28482.1 - 5.4e-10 39.3 0.2 2.4e-09 37.2 0.1 2.0 2 1 0 2 2 2 1 AhpC/TSA family DUF3199 PF11436.8 ETO28482.1 - 0.029 14.4 0.1 0.065 13.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3199) PH_5 PF15405.6 ETO28483.1 - 0.026 14.6 0.3 0.032 14.3 0.3 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain Sec15 PF04091.12 ETO28484.1 - 4.5e-33 115.0 6.4 1.9e-25 90.0 2.2 2.8 2 1 0 2 2 2 2 Exocyst complex subunit Sec15-like DUF1404 PF07185.11 ETO28484.1 - 0.015 15.0 0.1 0.027 14.2 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1404) Vps51 PF08700.11 ETO28486.1 - 2.3e-07 30.8 3.9 2.3e-07 30.8 3.9 2.5 2 0 0 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 ETO28486.1 - 0.12 12.6 9.4 0.14 12.4 3.3 2.9 2 1 0 2 2 2 0 Golgi transport complex subunit 5 DUF948 PF06103.11 ETO28487.1 - 0.071 13.4 3.1 0.21 11.9 3.1 1.9 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) FliS PF02561.14 ETO28487.1 - 0.27 11.5 6.1 0.051 13.8 1.6 2.1 2 0 0 2 2 2 0 Flagellar protein FliS BLOC1_2 PF10046.9 ETO28487.1 - 6.9 7.0 17.6 0.13 12.6 3.1 3.5 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3573 PF12097.8 ETO28487.1 - 9.1 5.0 7.4 24 3.6 7.4 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) HEAT_UF PF18817.1 ETO28491.1 - 0.012 15.8 0.2 0.029 14.6 0.2 1.6 1 0 0 1 1 1 0 Repeat of uncharacterized protein PH0542 TPR_7 PF13176.6 ETO28493.1 - 0.00081 19.2 0.5 5.1 7.3 0.1 4.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28493.1 - 0.016 15.5 1.7 9.7 6.6 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Clathrin PF00637.20 ETO28493.1 - 0.019 14.8 3.1 1.5 8.7 0.1 3.5 1 1 0 2 2 2 0 Region in Clathrin and VPS PH_5 PF15405.6 ETO28493.1 - 0.025 14.7 0.4 0.054 13.6 0.4 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain TPR_8 PF13181.6 ETO28493.1 - 0.64 10.4 4.1 21 5.7 0.3 3.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28493.1 - 6.2 6.8 11.3 2.7 8.0 0.8 3.7 3 1 0 3 3 3 0 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 ETO28494.1 - 8.4e-15 54.9 13.4 0.011 16.0 0.1 7.8 5 3 2 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain IKI3 PF04762.12 ETO28494.1 - 5.2e-06 24.8 8.4 1.1e-05 23.7 0.3 3.3 2 1 1 4 4 4 2 IKI3 family WD40 PF00400.32 ETO28494.1 - 0.0019 19.0 5.0 50 5.0 0.0 7.5 7 1 1 8 8 8 0 WD domain, G-beta repeat Glu_syn_central PF04898.14 ETO28494.1 - 0.028 13.9 0.0 0.09 12.2 0.0 1.8 2 0 0 2 2 2 0 Glutamate synthase central domain DUF4637 PF15470.6 ETO28495.1 - 0.013 15.3 0.1 0.016 14.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Menin PF05053.13 ETO28495.1 - 0.074 11.4 10.6 0.086 11.2 10.6 1.1 1 0 0 1 1 1 0 Menin CSG2 PF16965.5 ETO28495.1 - 0.24 10.3 2.5 0.28 10.1 2.5 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Zip PF02535.22 ETO28495.1 - 0.31 10.2 2.8 0.35 10.0 2.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter NPR3 PF03666.13 ETO28495.1 - 0.43 9.3 8.1 0.53 9.0 8.1 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Utp14 PF04615.13 ETO28495.1 - 0.48 8.9 8.5 0.53 8.8 8.5 1.0 1 0 0 1 1 1 0 Utp14 protein DUF4551 PF15087.6 ETO28495.1 - 1.1 8.0 5.4 1.6 7.5 5.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Macoilin PF09726.9 ETO28495.1 - 1.2 7.6 14.5 1.3 7.5 14.5 1.1 1 0 0 1 1 1 0 Macoilin family Presenilin PF01080.17 ETO28495.1 - 3 6.5 9.7 3.8 6.2 9.7 1.2 1 0 0 1 1 1 0 Presenilin DUF1980 PF09323.10 ETO28495.1 - 3.5 7.5 8.1 6 6.7 8.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) PIN_6 PF17146.4 ETO28496.1 - 1.5e-11 44.7 0.0 3.1e-11 43.6 0.0 1.6 1 1 0 1 1 1 1 PIN domain of ribonuclease THP2 PF09432.10 ETO28497.1 - 0.0036 17.4 0.2 0.0075 16.3 0.2 1.6 1 0 0 1 1 1 1 Tho complex subunit THP2 SAM_1 PF00536.30 ETO28497.1 - 0.029 14.8 0.3 0.083 13.3 0.3 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Cys_rich_KTR PF14205.6 ETO28497.1 - 0.11 12.3 0.4 0.26 11.1 0.4 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR Zip PF02535.22 ETO28499.1 - 0.00066 19.0 0.4 0.00084 18.7 0.4 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter FAM220 PF15487.6 ETO28499.1 - 0.018 14.7 6.7 0.028 14.1 6.7 1.2 1 0 0 1 1 1 0 FAM220 family Chordopox_A33R PF05966.12 ETO28499.1 - 0.045 13.0 0.5 0.045 13.0 0.5 2.2 2 0 0 2 2 2 0 Chordopoxvirus A33R protein Neur_chan_memb PF02932.16 ETO28499.1 - 0.15 12.1 1.8 0.13 12.3 0.7 1.5 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ETO28499.1 - 0.22 10.5 6.0 0.34 9.9 6.0 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CDC45 PF02724.14 ETO28499.1 - 0.5 8.6 8.2 0.67 8.2 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein PH PF00169.29 ETO28500.1 - 0.0012 19.3 1.1 0.0026 18.2 1.1 1.5 1 0 0 1 1 1 1 PH domain Polyoma_coat2 PF00761.20 ETO28500.1 - 1.9 8.1 5.8 5.8 6.5 2.0 2.1 2 0 0 2 2 2 0 Polyomavirus coat protein AAA_23 PF13476.6 ETO28500.1 - 2.4 8.6 14.9 3.1 8.3 14.9 1.1 1 0 0 1 1 1 0 AAA domain UDPGP PF01704.18 ETO28501.1 - 9.4e-09 34.4 0.1 1.2e-08 34.0 0.1 1.1 1 0 0 1 1 1 1 UTP--glucose-1-phosphate uridylyltransferase Borrelia_P83 PF05262.11 ETO28503.1 - 0.15 10.5 43.9 0.18 10.3 43.9 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein GYF_2 PF14237.6 ETO28505.1 - 1.2e-07 31.4 0.1 2.5e-07 30.4 0.1 1.6 1 0 0 1 1 1 1 GYF domain 2 CLP1_P PF16575.5 ETO28506.1 - 2.4e-15 56.8 0.0 3.6e-11 43.2 0.0 2.6 2 0 0 2 2 2 2 mRNA cleavage and polyadenylation factor CLP1 P-loop FtsK_SpoIIIE PF01580.18 ETO28506.1 - 0.055 12.8 0.0 0.097 12.0 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_22 PF13401.6 ETO28506.1 - 0.15 12.4 0.0 0.39 11.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain zf-RING_2 PF13639.6 ETO28507.1 - 1.4e-05 25.3 7.2 2.9e-05 24.3 7.2 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETO28507.1 - 0.0016 18.7 6.6 0.0069 16.6 6.6 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO28507.1 - 0.0018 18.1 7.9 0.0037 17.1 7.9 1.6 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO28507.1 - 0.016 15.0 6.7 0.037 13.9 6.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO28507.1 - 0.02 14.9 6.7 0.044 13.8 6.7 1.6 1 0 0 1 1 1 0 RING-type zinc-finger zf-ANAPC11 PF12861.7 ETO28507.1 - 0.052 13.6 3.5 0.14 12.3 3.5 1.8 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger Asp-B-Hydro_N PF05279.11 ETO28507.1 - 0.13 12.3 8.7 0.18 11.8 8.7 1.4 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Zn_ribbon_17 PF17120.5 ETO28507.1 - 0.29 10.8 4.3 0.52 10.0 4.3 1.4 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DDHD PF02862.17 ETO28507.1 - 0.48 10.5 5.7 0.61 10.2 5.7 1.2 1 0 0 1 1 1 0 DDHD domain RINGv PF12906.7 ETO28507.1 - 0.86 9.8 10.5 0.34 11.1 7.3 1.9 2 0 0 2 2 2 0 RING-variant domain zf-RING_4 PF14570.6 ETO28507.1 - 0.92 9.3 6.7 1.6 8.6 6.7 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-RING_11 PF17123.5 ETO28507.1 - 0.94 9.3 10.0 1.9 8.3 10.0 1.5 1 0 0 1 1 1 0 RING-like zinc finger DUF4407 PF14362.6 ETO28507.1 - 2.8 7.2 8.7 3.7 6.8 8.7 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Membralin PF09746.9 ETO28507.1 - 4.3 6.3 7.1 5.1 6.0 7.1 1.2 1 0 0 1 1 1 0 Tumour-associated protein ALMT PF11744.8 ETO28507.1 - 6.9 5.4 11.6 9.2 5.0 11.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter NESP55 PF06390.12 ETO28508.1 - 0.012 15.3 13.2 0.016 14.8 13.2 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Nop14 PF04147.12 ETO28508.1 - 1.1 7.4 21.2 1.2 7.3 21.2 1.0 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO28508.1 - 2.5 6.7 10.8 2.7 6.6 10.8 1.0 1 0 0 1 1 1 0 Presenilin RabGAP-TBC PF00566.18 ETO28508.1 - 2.6 7.7 3.9 2.9 7.5 3.9 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain SDA1 PF05285.12 ETO28508.1 - 2.6 7.4 22.3 3.1 7.2 22.3 1.1 1 0 0 1 1 1 0 SDA1 Menin PF05053.13 ETO28508.1 - 8.1 4.7 10.6 8.9 4.5 10.6 1.0 1 0 0 1 1 1 0 Menin MMM1 PF10296.9 ETO28509.1 - 0.023 13.8 0.2 0.023 13.8 0.2 1.9 1 1 1 2 2 2 0 Maintenance of mitochondrial morphology protein 1 Ctr PF04145.15 ETO28509.1 - 0.031 14.9 0.1 0.031 14.9 0.1 1.9 2 0 0 2 2 2 0 Ctr copper transporter family SID-1_RNA_chan PF13965.6 ETO28509.1 - 0.053 11.9 1.8 0.064 11.7 1.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Orf78 PF06024.12 ETO28509.1 - 0.41 11.0 0.0 0.41 11.0 0.0 2.6 1 1 1 2 2 2 0 Orf78 (ac78) CLN3 PF02487.17 ETO28509.1 - 1.1 8.3 3.7 0.23 10.5 0.2 1.6 1 1 1 2 2 2 0 CLN3 protein FAM176 PF14851.6 ETO28509.1 - 6 6.5 6.9 16 5.1 0.1 2.2 2 0 0 2 2 2 0 FAM176 family Neur_chan_memb PF02932.16 ETO28510.1 - 0.00013 22.2 5.7 0.00013 22.2 5.7 1.7 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region SID-1_RNA_chan PF13965.6 ETO28510.1 - 0.0027 16.2 2.7 0.0027 16.2 2.7 1.9 1 1 1 2 2 2 1 dsRNA-gated channel SID-1 CDC45 PF02724.14 ETO28510.1 - 0.0032 15.8 1.3 0.0037 15.6 1.3 1.1 1 0 0 1 1 1 1 CDC45-like protein WBP-1 PF11669.8 ETO28510.1 - 0.014 16.0 1.3 0.014 16.0 1.3 2.7 1 1 1 2 2 2 0 WW domain-binding protein 1 DDHD PF02862.17 ETO28510.1 - 0.016 15.3 2.4 0.024 14.8 2.4 1.3 1 0 0 1 1 1 0 DDHD domain OAD_gamma PF04277.13 ETO28510.1 - 0.018 15.6 0.2 0.018 15.6 0.2 3.6 2 1 0 2 2 1 0 Oxaloacetate decarboxylase, gamma chain DUF2207 PF09972.9 ETO28510.1 - 0.036 12.8 3.4 0.047 12.5 3.4 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) FGF-BP1 PF06473.12 ETO28510.1 - 0.13 12.1 21.4 1.9 8.2 16.5 2.3 1 1 1 2 2 2 0 FGF binding protein 1 (FGF-BP1) EphA2_TM PF14575.6 ETO28510.1 - 0.99 10.3 0.0 0.99 10.3 0.0 2.8 2 1 0 2 2 1 0 Ephrin type-A receptor 2 transmembrane domain Orf78 PF06024.12 ETO28510.1 - 3.7 7.9 14.8 23 5.4 12.2 2.7 2 1 0 2 2 2 0 Orf78 (ac78) DUF4337 PF14235.6 ETO28510.1 - 9 6.4 8.6 0.072 13.2 0.9 1.6 2 0 0 2 2 1 0 Domain of unknown function (DUF4337) Pkinase PF00069.25 ETO28511.1 - 1.8e-13 50.5 0.0 2.8e-13 49.8 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain DUF2764 PF10962.8 ETO28511.1 - 0.14 11.6 0.0 0.2 11.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2764) Ank_2 PF12796.7 ETO28512.1 - 3.7e-14 53.1 0.2 5.9e-14 52.4 0.2 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO28512.1 - 4.5e-14 52.6 0.2 5.9e-06 26.7 0.0 2.7 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO28512.1 - 8e-12 45.2 0.0 1.9e-06 28.1 0.0 2.3 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO28512.1 - 1.5e-11 44.2 0.7 6.1e-05 23.3 0.1 3.3 3 0 0 3 3 3 3 Ankyrin repeat Ank_3 PF13606.6 ETO28512.1 - 1.8e-10 40.1 0.5 1.3e-05 25.2 0.0 3.5 3 0 0 3 3 3 2 Ankyrin repeat PUF PF00806.19 ETO28512.1 - 0.05 13.3 0.0 0.79 9.5 0.0 2.5 2 0 0 2 2 2 0 Pumilio-family RNA binding repeat IATP PF04568.12 ETO28514.1 - 8 7.0 6.8 0.44 11.0 1.1 1.9 2 0 0 2 2 2 0 Mitochondrial ATPase inhibitor, IATP ALIX_LYPXL_bnd PF13949.6 ETO28515.1 - 0.00068 19.0 6.1 0.003 16.9 3.0 2.4 2 0 0 2 2 2 1 ALIX V-shaped domain binding to HIV Endotoxin_N PF03945.14 ETO28515.1 - 0.052 13.3 0.2 0.16 11.7 0.2 1.8 1 0 0 1 1 1 0 delta endotoxin, N-terminal domain zf-C2H2_12 PF18658.1 ETO28515.1 - 0.075 12.6 0.1 0.58 9.8 0.2 2.5 2 0 0 2 2 2 0 Zinc-finger C2H2-type DUF3439 PF11921.8 ETO28515.1 - 0.12 12.3 1.1 0.31 11.0 1.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF4407 PF14362.6 ETO28515.1 - 7.9 5.7 7.6 1.9 7.8 3.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) MT PF12777.7 ETO28516.1 - 8e-24 84.3 26.2 3e-19 69.3 4.5 2.4 2 1 0 2 2 2 2 Microtubule-binding stalk of dynein motor AAA_9 PF12781.7 ETO28516.1 - 2.3e-17 62.9 0.2 2.3e-17 62.9 0.2 2.7 3 0 0 3 3 3 1 ATP-binding dynein motor region AAA_8 PF12780.7 ETO28516.1 - 1.1e-08 34.8 0.7 1.1e-08 34.8 0.7 2.5 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 DAG_kinase_N PF14513.6 ETO28516.1 - 0.0026 18.0 5.7 0.0026 18.0 5.7 2.6 2 1 0 2 2 2 1 Diacylglycerol kinase N-terminus ERM PF00769.19 ETO28516.1 - 1.5 8.6 29.0 1.1 9.0 11.3 2.3 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Borrelia_P83 PF05262.11 ETO28516.1 - 2 6.8 26.8 0.55 8.7 12.1 2.2 2 0 0 2 2 2 0 Borrelia P83/100 protein SOAR PF16533.5 ETO28516.1 - 3.5 7.7 16.5 2.6 8.1 0.3 3.8 3 1 1 4 4 4 0 STIM1 Orai1-activating region APG6_N PF17675.1 ETO28516.1 - 8.3 6.9 26.5 0.85 10.1 3.4 2.8 2 1 0 2 2 2 0 Apg6 coiled-coil region AAA_9 PF12781.7 ETO28517.1 - 9.6e-47 158.9 4.5 1.1e-46 158.8 4.5 1.0 1 0 0 1 1 1 1 ATP-binding dynein motor region Remorin_C PF03763.13 ETO28517.1 - 0.011 15.6 2.1 0.013 15.4 0.8 1.7 1 1 1 2 2 2 0 Remorin, C-terminal region Rap_GAP PF02145.15 ETO28517.1 - 0.04 13.5 0.0 0.056 13.0 0.0 1.4 1 1 0 1 1 1 0 Rap/ran-GAP Dynein_C PF18199.1 ETO28518.1 - 9.1e-69 232.0 0.0 1.8e-68 231.0 0.0 1.4 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETO28518.1 - 1.2e-53 181.3 0.4 2.6e-53 180.2 0.2 1.7 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ETO28518.1 - 1.7e-39 134.6 0.6 3.7e-38 130.3 0.0 2.4 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain Cation_ATPase_C PF00689.21 ETO28519.1 - 4.7e-17 62.3 6.5 4.7e-17 62.3 6.5 1.9 1 1 1 2 2 2 1 Cation transporting ATPase, C-terminus MotB_plug PF13677.6 ETO28519.1 - 0.035 13.7 0.1 0.075 12.6 0.1 1.6 1 0 0 1 1 1 0 Membrane MotB of proton-channel complex MotA/MotB Cation_ATPase_C PF00689.21 ETO28520.1 - 1.9e-15 57.0 1.0 1.9e-15 57.0 1.0 1.8 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETO28520.1 - 1.2e-11 45.3 0.1 6.1e-10 39.7 0.1 2.2 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETO28520.1 - 0.02 14.6 2.6 0.02 14.6 2.6 2.6 2 1 0 3 3 3 0 haloacid dehalogenase-like hydrolase NTP_transf_2 PF01909.23 ETO28521.1 - 1.6e-05 25.1 0.4 5.2e-05 23.5 0.0 2.0 2 0 0 2 2 2 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO28521.1 - 0.013 15.6 0.1 0.043 13.9 0.1 1.9 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase LMBR1 PF04791.16 ETO28521.1 - 2.5 6.9 7.0 3.9 6.3 7.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Paramyxo_ncap PF00973.19 ETO28521.1 - 7.3 5.4 9.7 31 3.3 10.8 1.5 2 0 0 2 2 2 0 Paramyxovirus nucleocapsid protein DUF4500 PF14937.6 ETO28523.1 - 0.0075 16.3 0.5 0.2 11.7 0.0 2.2 1 1 1 2 2 2 1 Domain of unknown function (DUF4500) DUF4482 PF14818.6 ETO28523.1 - 0.016 16.1 0.3 0.021 15.7 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4482) UPF0542 PF15086.6 ETO28523.1 - 0.03 14.3 2.9 0.04 13.8 2.9 1.2 1 0 0 1 1 1 0 Uncharacterised protein family UPF0542 TMEM144 PF07857.12 ETO28523.1 - 0.035 13.1 0.2 0.035 13.1 0.2 1.0 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters AgrB PF04647.15 ETO28523.1 - 0.044 13.1 0.9 0.043 13.1 0.9 1.1 1 0 0 1 1 1 0 Accessory gene regulator B S1FA PF04689.13 ETO28523.1 - 0.16 12.2 2.2 0.22 11.7 2.2 1.2 1 0 0 1 1 1 0 DNA binding protein S1FA ETRAMP PF09716.10 ETO28523.1 - 0.17 12.0 7.8 0.25 11.4 7.8 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Kelch_2 PF07646.15 ETO28523.1 - 0.2 11.7 0.2 0.33 11.0 0.2 1.3 1 0 0 1 1 1 0 Kelch motif FeS_assembly_P PF01883.19 ETO28524.1 - 2.3e-15 56.5 0.0 3.7e-15 55.9 0.0 1.3 1 0 0 1 1 1 1 Iron-sulfur cluster assembly protein Glyco_hydro_1 PF00232.18 ETO28524.1 - 0.085 11.2 0.1 0.16 10.4 0.1 1.4 1 1 0 1 1 1 0 Glycosyl hydrolase family 1 EVC2_like PF12297.8 ETO28524.1 - 0.11 11.1 3.6 1.4 7.6 0.2 2.2 1 1 1 2 2 2 0 Ellis van Creveld protein 2 like protein ATG16 PF08614.11 ETO28525.1 - 4.1 7.6 70.1 1.9 8.6 2.9 5.2 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Tubulin PF00091.25 ETO28527.1 - 2.8e-61 207.1 0.0 4.2e-61 206.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain zf-TRAF PF02176.18 ETO28529.1 - 2.9e-17 63.1 31.5 6.4e-12 46.0 5.2 4.7 3 1 2 5 5 5 3 TRAF-type zinc finger PH PF00169.29 ETO28529.1 - 3.5e-08 33.9 0.3 2.6e-07 31.1 0.0 2.6 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ETO28529.1 - 0.011 15.8 0.0 0.052 13.6 0.0 2.1 1 0 0 1 1 1 0 PH domain PH_11 PF15413.6 ETO28529.1 - 0.033 14.6 0.0 0.033 14.6 0.0 2.6 3 1 0 3 3 3 0 Pleckstrin homology domain PH_8 PF15409.6 ETO28529.1 - 0.044 14.1 0.4 0.19 12.0 0.0 2.3 2 0 0 2 2 2 0 Pleckstrin homology domain zf-ACC PF17848.1 ETO28529.1 - 0.29 11.2 10.3 0.87 9.7 0.5 4.1 3 0 0 3 3 3 0 Acetyl-coA carboxylase zinc finger domain zf-Di19 PF05605.12 ETO28529.1 - 0.79 10.1 17.8 8.2 6.8 4.7 4.0 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Exonuc_VII_L PF02601.15 ETO28529.1 - 4.9 6.6 8.7 9 5.8 8.7 1.5 1 0 0 1 1 1 0 Exonuclease VII, large subunit Pkinase_fungal PF17667.1 ETO28530.1 - 1.5e-06 27.3 5.8 1.3e-05 24.2 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase Pkinase PF00069.25 ETO28530.1 - 0.00043 19.7 0.0 0.00066 19.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Kei1 PF08552.11 ETO28530.1 - 0.45 10.4 1.4 0.68 9.8 1.4 1.2 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Neur_chan_memb PF02932.16 ETO28530.1 - 0.78 9.8 3.5 0.74 9.8 2.5 1.6 1 1 1 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO28530.1 - 1.3 8.2 3.7 1.9 7.7 3.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO28530.1 - 6.9 5.3 10.4 9.9 4.8 10.4 1.1 1 0 0 1 1 1 0 Presenilin Ins134_P3_kin PF05770.11 ETO28531.1 - 4.8e-18 65.4 0.7 1.1e-10 41.4 0.1 3.1 3 1 0 3 3 3 2 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain RTT107_BRCT_6 PF16771.5 ETO28531.1 - 0.34 11.1 6.7 0.12 12.6 1.5 2.5 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain HAD_2 PF13419.6 ETO28532.1 - 1.2e-19 71.1 0.9 3.7e-19 69.5 0.9 2.0 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase PF00702.26 ETO28532.1 - 7e-07 29.7 0.0 2.3e-06 28.0 0.0 1.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETO28532.1 - 2.6e-06 27.4 0.0 4.6e-06 26.6 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like PGP_phosphatase PF09419.10 ETO28532.1 - 0.00041 20.0 0.1 0.011 15.3 0.0 2.4 2 0 0 2 2 2 1 Mitochondrial PGP phosphatase Ins134_P3_kin_N PF17927.1 ETO28532.1 - 0.00055 20.3 0.1 0.0018 18.6 0.1 2.0 1 0 0 1 1 1 1 Inositol 1,3,4-trisphosphate 5/6-kinase pre-ATP-grasp domain PNK3P PF08645.11 ETO28532.1 - 0.018 14.7 1.1 0.06 13.0 0.3 2.1 2 1 0 2 2 2 0 Polynucleotide kinase 3 phosphatase O-FucT PF10250.9 ETO28533.1 - 0.089 12.5 1.1 0.17 11.6 0.0 1.9 2 1 0 2 2 2 0 GDP-fucose protein O-fucosyltransferase Peroxin-13_N PF04088.13 ETO28534.1 - 5.5 7.2 7.1 2.3 8.5 3.8 2.0 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Peptidase_S49_N PF08496.10 ETO28534.1 - 9 6.3 11.3 14 5.8 9.0 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal SAM_2 PF07647.17 ETO28535.1 - 1.1e-05 25.4 1.0 8.3e-05 22.6 0.2 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO28535.1 - 0.00015 22.1 1.2 0.00031 21.1 0.3 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) Vfa1 PF08432.10 ETO28535.1 - 0.0011 19.3 3.1 0.0014 19.0 3.1 1.2 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 SAM_PNT PF02198.16 ETO28535.1 - 0.0017 18.3 0.3 0.63 10.1 0.1 2.3 2 0 0 2 2 2 2 Sterile alpha motif (SAM)/Pointed domain GNAT_acetyltr_2 PF13718.6 ETO28535.1 - 0.0083 15.5 0.3 0.012 15.0 0.3 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase 2 Atrophin-1 PF03154.15 ETO28535.1 - 0.011 14.1 3.4 0.013 13.8 3.4 1.1 1 0 0 1 1 1 0 Atrophin-1 family CPSF100_C PF13299.6 ETO28535.1 - 0.034 14.3 1.3 0.054 13.7 1.3 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Peroxin-13_N PF04088.13 ETO28535.1 - 0.08 13.2 0.9 0.14 12.5 0.9 1.3 1 0 0 1 1 1 0 Peroxin 13, N-terminal region FAM176 PF14851.6 ETO28535.1 - 0.19 11.4 2.0 0.28 10.8 2.0 1.2 1 0 0 1 1 1 0 FAM176 family Peptidase_S49_N PF08496.10 ETO28535.1 - 0.7 9.9 4.8 1.1 9.3 4.8 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4325 PF14213.6 ETO28537.1 - 0.092 12.5 0.1 0.21 11.3 0.1 1.6 1 0 0 1 1 1 0 STAS-like domain of unknown function (DUF4325) Rhabdo_NV PF02484.15 ETO28538.1 - 0.12 12.5 0.1 28 4.9 0.0 2.6 2 0 0 2 2 2 0 Rhabdovirus Non-virion protein Sld5 PF05916.11 ETO28538.1 - 7 7.2 7.5 1.5 9.4 1.2 2.7 2 1 0 2 2 2 0 GINS complex protein PBP1_TM PF14812.6 ETO28538.1 - 9.8 6.6 9.2 32 5.0 5.1 3.0 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF5090 PF17009.5 ETO28539.1 - 0.24 11.4 6.7 0.22 11.5 3.8 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5090) PBP1_TM PF14812.6 ETO28540.1 - 0.069 13.5 2.7 0.11 12.9 2.7 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.25 ETO28542.1 - 2.3e-65 220.6 0.3 3.1e-65 220.2 0.3 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28542.1 - 4.1e-41 141.0 0.1 6.4e-40 137.1 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO28542.1 - 3.4e-05 23.3 0.0 0.00019 20.9 0.0 2.1 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ETO28542.1 - 0.0021 17.7 0.3 0.0047 16.6 0.1 1.7 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 ETO28542.1 - 0.013 15.0 0.0 0.021 14.3 0.0 1.3 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Kdo PF06293.14 ETO28542.1 - 0.075 12.4 1.5 0.12 11.7 1.5 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO28542.1 - 0.096 12.6 1.2 0.23 11.4 0.3 1.9 1 1 1 2 2 2 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO28542.1 - 0.14 10.9 1.1 0.87 8.3 0.4 2.0 1 1 1 2 2 2 0 Fungal protein kinase TPM_phosphatase PF04536.14 ETO28544.1 - 0.082 13.1 0.0 0.082 13.1 0.0 2.8 3 0 0 3 3 3 0 TPM domain WD40 PF00400.32 ETO28545.1 - 1.4e-08 35.2 4.5 0.12 13.3 0.0 5.9 6 0 0 6 6 6 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28545.1 - 5e-05 23.5 0.0 0.00018 21.7 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF3347 PF11827.8 ETO28545.1 - 0.0093 16.2 14.9 0.0093 16.2 14.9 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3347) PIP5K PF01504.18 ETO28546.1 - 9.3e-70 235.0 3.4 1.5e-69 234.3 3.4 1.3 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase TRIQK PF15168.6 ETO28547.1 - 0.017 15.0 0.1 0.046 13.6 0.0 1.8 1 1 0 1 1 1 0 Triple QxxK/R motif-containing protein family EssA PF10661.9 ETO28547.1 - 0.019 14.8 1.1 0.043 13.6 0.0 1.9 2 0 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA L_HMGIC_fpl PF10242.9 ETO28547.1 - 0.13 12.5 3.4 0.087 13.0 0.4 1.9 2 0 0 2 2 2 0 Lipoma HMGIC fusion partner-like protein Neurensin PF14927.6 ETO28547.1 - 0.13 11.9 1.0 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 Neurensin TAF4 PF05236.14 ETO28550.1 - 0.0083 15.9 0.9 0.0089 15.8 0.9 1.2 1 0 0 1 1 1 1 Transcription initiation factor TFIID component TAF4 family Roughex PF06020.11 ETO28550.1 - 0.21 10.6 4.0 0.32 10.1 4.0 1.3 1 0 0 1 1 1 0 Drosophila roughex protein Aldo_ket_red PF00248.21 ETO28553.1 - 1.3e-52 178.9 0.0 1.6e-52 178.6 0.0 1.1 1 0 0 1 1 1 1 Aldo/keto reductase family FBPase PF00316.20 ETO28554.1 - 1.5e-12 47.4 0.1 2.1e-12 46.9 0.1 1.2 1 0 0 1 1 1 1 Fructose-1-6-bisphosphatase, N-terminal domain Helicase_C PF00271.31 ETO28555.1 - 2.6e-18 66.4 0.2 1.1e-17 64.4 0.1 2.0 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RecQ_Zn_bind PF16124.5 ETO28555.1 - 1.4e-13 51.4 2.1 1.4e-13 51.4 2.1 2.2 2 0 0 2 2 2 1 RecQ zinc-binding Fer4_6 PF12837.7 ETO28555.1 - 0.15 12.2 1.9 0.42 10.8 1.9 1.8 1 0 0 1 1 1 0 4Fe-4S binding domain Nucleo_P87 PF07267.11 ETO28556.1 - 4.5 6.0 16.8 6.9 5.4 16.8 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 CIAPIN1 PF05093.13 ETO28556.1 - 8 7.0 6.7 28 5.3 6.7 2.1 1 1 0 1 1 1 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis Tubulin_C PF03953.17 ETO28558.1 - 9.5e-42 142.1 0.2 1.9e-41 141.2 0.2 1.5 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO28558.1 - 1.7e-08 34.9 0.2 6.4e-08 33.0 0.1 1.9 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain BTHB PF18410.1 ETO28558.1 - 0.16 11.8 1.0 0.3 10.9 0.1 1.9 2 0 0 2 2 2 0 Basic tilted helix bundle domain Tubulin PF00091.25 ETO28559.1 - 7.1e-46 156.9 0.0 8.4e-46 156.7 0.0 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 ETO28559.1 - 7e-06 26.3 0.0 9.5e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ETO28559.1 - 0.17 11.5 0.0 0.36 10.5 0.0 1.5 2 0 0 2 2 2 0 Tubulin domain NOA36 PF06524.12 ETO28560.1 - 0.14 11.4 13.2 0.24 10.7 1.4 2.2 2 0 0 2 2 2 0 NOA36 protein zf-C3HC4 PF00097.25 ETO28560.1 - 0.51 10.3 11.2 1.4 8.9 11.2 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO28560.1 - 1.5 8.9 10.2 3.5 7.7 10.2 1.7 1 0 0 1 1 1 0 zinc-RING finger domain TrbE PF11100.8 ETO28561.1 - 0.044 14.0 0.4 0.082 13.1 0.4 1.5 1 0 0 1 1 1 0 Conjugal transfer protein TrbE SRP_SPB PF02978.19 ETO28561.1 - 0.06 14.0 0.1 0.082 13.5 0.1 1.3 1 0 0 1 1 1 0 Signal peptide binding domain NAD_binding_2 PF03446.15 ETO28562.1 - 1.3e-34 119.6 0.7 1.2e-17 64.5 0.0 2.5 2 0 0 2 2 2 2 NAD binding domain of 6-phosphogluconate dehydrogenase 6PGD PF00393.19 ETO28562.1 - 1.4e-30 106.7 6.2 4e-20 72.4 0.7 2.2 1 1 1 2 2 2 2 6-phosphogluconate dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 ETO28562.1 - 0.009 15.9 0.1 0.027 14.3 0.0 1.9 2 0 0 2 2 2 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain F420_oxidored PF03807.17 ETO28562.1 - 0.03 14.9 0.1 0.1 13.2 0.1 2.1 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent DUF1829 PF08862.10 ETO28562.1 - 0.06 13.8 0.0 0.2 12.2 0.0 1.8 1 0 0 1 1 1 0 Domain of unknown function DUF1829 Shikimate_DH PF01488.20 ETO28562.1 - 0.096 12.7 0.0 0.25 11.4 0.0 1.7 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase ANAPC4_WD40 PF12894.7 ETO28563.1 - 3.9e-05 23.9 0.3 1.1 9.6 0.0 3.8 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain MVP_shoulder PF11978.8 ETO28563.1 - 0.11 12.5 0.4 2.6 8.1 0.0 2.6 2 0 0 2 2 2 0 Shoulder domain U71 PF17474.2 ETO28563.1 - 0.2 11.6 0.1 0.2 11.6 0.1 2.0 2 0 0 2 2 2 0 Tegument protein UL11 homolog Toast_rack_N PF17115.5 ETO28563.1 - 0.81 10.0 8.3 1 9.7 6.3 2.0 2 0 0 2 2 2 0 N-terminal domain of toast_rack, DUF2154 AhpC-TSA PF00578.21 ETO28565.1 - 1.8e-38 131.2 0.1 3.9e-38 130.2 0.0 1.6 2 0 0 2 2 2 1 AhpC/TSA family Redoxin PF08534.10 ETO28565.1 - 6.7e-15 55.1 0.0 9.7e-15 54.5 0.0 1.2 1 0 0 1 1 1 1 Redoxin 1-cysPrx_C PF10417.9 ETO28565.1 - 5.5e-08 32.5 0.0 1.1e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 C-terminal domain of 1-Cys peroxiredoxin SCO1-SenC PF02630.14 ETO28565.1 - 0.047 13.6 0.2 0.18 11.8 0.1 1.9 2 0 0 2 2 2 0 SCO1/SenC AAA PF00004.29 ETO28566.1 - 1.6e-05 25.3 0.0 3.7e-05 24.2 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Pox_P21 PF05313.12 ETO28566.1 - 0.0071 15.9 1.2 0.011 15.3 1.2 1.3 1 0 0 1 1 1 1 Poxvirus P21 membrane protein AAA_22 PF13401.6 ETO28566.1 - 0.0098 16.2 0.2 0.064 13.5 0.0 2.4 2 2 1 3 3 3 1 AAA domain Phospholamban PF04272.14 ETO28566.1 - 6.5 6.3 9.0 8.8 5.9 7.9 1.9 1 1 1 2 2 2 0 Phospholamban AAA_11 PF13086.6 ETO28567.1 - 0.0079 16.0 7.9 0.08 12.7 0.0 2.1 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO28567.1 - 0.01 16.1 1.5 0.014 15.7 0.2 1.9 2 1 0 2 2 2 0 AAA domain AAA_16 PF13191.6 ETO28567.1 - 0.011 16.1 0.1 0.025 15.0 0.1 1.6 1 1 0 1 1 1 0 AAA ATPase domain DUF3762 PF12591.8 ETO28567.1 - 0.016 15.4 0.4 0.6 10.4 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3762) RNA_helicase PF00910.22 ETO28567.1 - 0.028 14.8 0.2 0.073 13.5 0.2 1.7 1 0 0 1 1 1 0 RNA helicase DUF87 PF01935.17 ETO28567.1 - 0.036 14.2 3.9 0.91 9.6 0.0 2.3 2 0 0 2 2 2 0 Helicase HerA, central domain AAA_7 PF12775.7 ETO28567.1 - 0.053 13.0 0.9 0.067 12.7 0.1 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA PF00004.29 ETO28567.1 - 0.06 13.8 1.2 0.32 11.4 0.1 2.3 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF5034 PF16437.5 ETO28567.1 - 0.062 13.3 0.3 0.094 12.7 0.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF5034) AAA_19 PF13245.6 ETO28567.1 - 0.079 13.3 0.1 0.19 12.1 0.0 1.6 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO28567.1 - 0.22 12.0 4.0 6 7.4 0.1 2.2 2 0 0 2 2 2 0 ABC transporter AIG1 PF04548.16 ETO28567.1 - 0.32 10.3 0.1 0.32 10.3 0.1 2.2 2 0 0 2 2 2 0 AIG1 family Hemerythrin PF01814.23 ETO28568.1 - 1.1e-06 29.3 0.1 1.6e-06 28.8 0.1 1.3 1 0 0 1 1 1 1 Hemerythrin HHE cation binding domain DUF2972 PF11186.8 ETO28568.1 - 0.064 13.2 2.2 1.6 8.6 0.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2972) DUF4795 PF16043.5 ETO28568.1 - 0.073 12.7 0.3 0.1 12.2 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4795) WD40 PF00400.32 ETO28569.1 - 2.3e-39 132.7 27.1 2e-06 28.4 0.6 7.9 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28569.1 - 2.9e-09 37.1 4.7 0.072 13.4 0.0 5.8 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO28569.1 - 8.3e-07 28.0 7.3 0.077 11.6 0.5 5.2 2 2 1 5 5 5 3 Nucleoporin Nup120/160 MIR PF02815.19 ETO28569.1 - 0.019 14.8 1.0 0.029 14.2 0.4 1.6 2 0 0 2 2 2 0 MIR domain Marek_SORF3 PF07153.11 ETO28569.1 - 0.044 13.1 0.1 8.3 5.7 0.0 2.9 2 1 1 3 3 3 0 Marek's disease-like virus SORF3 protein HEAT PF02985.22 ETO28570.1 - 6.4e-10 38.4 5.1 0.52 10.7 0.0 9.5 11 0 0 11 11 11 2 HEAT repeat HEAT_2 PF13646.6 ETO28570.1 - 2.7e-08 34.1 1.2 1.9 9.0 0.0 6.8 6 1 1 7 7 7 2 HEAT repeats ParcG PF10274.9 ETO28570.1 - 6e-08 33.0 3.6 0.00053 20.2 0.1 4.9 4 1 1 5 5 5 1 Parkin co-regulated protein UME PF08064.13 ETO28570.1 - 2.7e-06 27.2 4.0 0.52 10.2 0.0 6.5 7 2 1 8 8 8 2 UME (NUC010) domain HEAT_EZ PF13513.6 ETO28570.1 - 1.1e-05 25.9 0.0 0.086 13.4 0.0 5.4 5 0 0 5 5 5 1 HEAT-like repeat DUF3385 PF11865.8 ETO28570.1 - 0.0077 16.2 7.0 2.3 8.1 0.0 5.2 5 2 2 7 7 7 2 Domain of unknown function (DUF3385) Cnd1 PF12717.7 ETO28570.1 - 0.071 13.1 2.5 6.1 6.9 0.0 4.4 3 2 1 4 4 4 0 non-SMC mitotic condensation complex subunit 1 DUF1075 PF06388.11 ETO28570.1 - 0.11 12.6 0.2 1.6 8.8 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1075) Vac14_Fab1_bd PF12755.7 ETO28570.1 - 0.14 12.7 7.6 0.45 11.1 0.1 5.2 5 1 1 7 7 7 0 Vacuolar 14 Fab1-binding region SICA_C PF12879.7 ETO28570.1 - 0.61 10.1 7.6 0.78 9.8 0.2 2.8 3 0 0 3 3 3 0 SICA C-terminal inner membrane domain Tubulin PF00091.25 ETO28571.1 - 4.6e-18 66.1 0.0 8.8e-18 65.2 0.0 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO28571.1 - 7.4e-17 61.7 0.0 1e-16 61.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO28571.1 - 0.056 12.6 0.1 0.089 12.0 0.1 1.4 1 1 0 1 1 1 0 Tubulin like ORF11CD3 PF10549.9 ETO28571.1 - 0.13 12.4 0.0 10 6.3 0.0 2.4 2 0 0 2 2 2 0 ORF11CD3 domain Pkinase PF00069.25 ETO28572.1 - 2e-11 43.7 0.0 2e-11 43.7 0.0 2.9 4 0 0 4 4 4 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28572.1 - 0.00027 20.3 0.5 0.00049 19.5 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase DUF4407 PF14362.6 ETO28572.1 - 0.18 11.2 2.1 0.3 10.4 2.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PWI PF01480.17 ETO28574.1 - 3.4e-08 33.7 0.6 1.1e-07 32.1 0.1 2.0 2 0 0 2 2 2 1 PWI domain DUF2830 PF11125.8 ETO28574.1 - 0.052 13.5 0.3 0.15 12.0 0.3 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2830) Nop14 PF04147.12 ETO28575.1 - 0.0055 15.0 9.3 0.0062 14.8 9.3 1.0 1 0 0 1 1 1 1 Nop14-like family BSP_II PF05432.11 ETO28575.1 - 0.013 15.2 22.1 0.017 14.8 22.1 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF2457 PF10446.9 ETO28575.1 - 0.024 13.8 16.4 0.033 13.3 16.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO28575.1 - 0.036 12.4 11.5 0.044 12.1 11.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Utp14 PF04615.13 ETO28575.1 - 0.04 12.5 11.7 0.039 12.5 11.7 1.1 1 0 0 1 1 1 0 Utp14 protein NST1 PF13945.6 ETO28575.1 - 0.089 12.9 25.1 0.17 12.0 25.1 1.5 1 0 0 1 1 1 0 Salt tolerance down-regulator Spt5_N PF11942.8 ETO28575.1 - 0.22 12.5 10.8 0.38 11.8 10.8 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal Menin PF05053.13 ETO28575.1 - 0.24 9.7 13.4 0.31 9.3 13.4 1.2 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO28575.1 - 0.4 9.8 4.0 0.38 9.9 4.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO28575.1 - 0.48 9.1 10.3 0.59 8.8 10.3 1.2 1 0 0 1 1 1 0 Presenilin DUF3807 PF12720.7 ETO28575.1 - 0.51 10.6 14.6 0.73 10.1 14.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) Sorting_nexin PF03700.13 ETO28575.1 - 0.73 10.4 16.6 0.06 13.9 12.0 1.5 2 0 0 2 2 1 0 Sorting nexin, N-terminal domain RRN3 PF05327.11 ETO28575.1 - 0.92 8.0 10.8 1.2 7.6 10.8 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Pex14_N PF04695.13 ETO28575.1 - 1.1 9.9 19.1 17 6.1 19.1 2.3 1 1 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4637 PF15470.6 ETO28575.1 - 1.3 8.7 11.6 2 8.2 11.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) XAP5 PF04921.14 ETO28575.1 - 1.4 8.7 14.0 2 8.1 14.0 1.3 1 0 0 1 1 1 0 XAP5, circadian clock regulator PNISR PF15996.5 ETO28575.1 - 3.9 7.7 11.9 5 7.3 11.9 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR NPR3 PF03666.13 ETO28575.1 - 5.2 5.7 13.6 7.2 5.3 13.6 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 COPI_C PF06957.11 ETO28575.1 - 5.8 5.5 8.9 9.9 4.8 8.9 1.3 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus ALMT PF11744.8 ETO28575.1 - 7 5.4 8.2 8.8 5.0 8.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF485 PF04341.12 ETO28579.1 - 0.15 12.0 0.0 0.28 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF485 Phage_holin_6_1 PF09682.10 ETO28579.1 - 0.18 12.2 1.4 0.34 11.3 0.1 2.1 2 1 0 2 2 2 0 Bacteriophage holin of superfamily 6 (Holin_LLH) MAP17 PF15807.5 ETO28579.1 - 2 8.6 4.7 36 4.6 0.3 3.0 3 0 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF1754 PF08555.10 ETO28579.1 - 2.9 8.7 16.3 0.31 11.9 1.1 2.8 2 1 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Orf78 PF06024.12 ETO28579.1 - 5.5 7.3 12.8 1.5 9.2 3.6 3.2 3 1 0 3 3 3 0 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO28579.1 - 6.1 7.5 20.1 0.1 13.2 9.1 3.1 3 0 0 3 3 3 0 Secretin N-terminal domain O-antigen_lig PF13425.6 ETO28579.1 - 6.8 5.4 8.5 7.1 5.3 6.3 2.0 1 1 1 2 2 2 0 O-antigen ligase like membrane protein Ras PF00071.22 ETO28580.1 - 3.2e-20 72.3 0.9 1.8e-16 60.1 0.0 3.5 3 0 0 3 3 3 2 Ras family Roc PF08477.13 ETO28580.1 - 6.7e-13 48.9 1.0 7.6e-09 35.8 0.0 3.4 3 0 0 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase AAA_16 PF13191.6 ETO28580.1 - 0.00077 19.9 0.0 0.0034 17.8 0.0 2.0 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO28580.1 - 0.0088 16.0 0.1 2.4 8.0 0.1 2.9 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ETO28580.1 - 0.01 15.4 0.0 0.037 13.6 0.0 2.0 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_19 PF13245.6 ETO28580.1 - 0.069 13.5 0.0 0.24 11.7 0.0 1.8 1 1 1 2 2 2 0 AAA domain TPR_2 PF07719.17 ETO28581.1 - 7.6e-19 66.2 2.1 0.00041 20.2 0.4 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28581.1 - 1.4e-18 65.9 5.3 9e-07 28.5 0.4 6.2 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO28581.1 - 4.5e-18 64.3 3.9 0.00094 19.4 0.0 6.5 5 2 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28581.1 - 1.2e-12 46.9 0.8 0.019 15.2 0.1 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO28581.1 - 1.1e-08 35.1 0.3 0.00069 20.2 0.1 5.5 3 3 3 6 6 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28581.1 - 2e-07 30.6 0.2 0.12 12.5 0.0 4.9 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO28581.1 - 7.8e-07 29.7 0.0 0.0003 21.4 0.0 3.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO28581.1 - 1e-06 29.0 2.9 0.72 10.6 0.1 5.7 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28581.1 - 3.8e-06 26.5 5.4 0.00041 20.0 0.1 3.9 3 1 1 4 4 4 1 TPR repeat TPR_19 PF14559.6 ETO28581.1 - 0.00025 21.5 4.7 0.041 14.4 0.2 3.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO28581.1 - 0.00066 19.8 0.1 0.062 13.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28581.1 - 0.00085 19.6 5.1 0.32 11.3 0.1 4.0 2 2 2 4 4 4 1 Tetratricopeptide repeat TPR_20 PF14561.6 ETO28581.1 - 0.0011 19.2 0.2 0.073 13.4 0.0 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat Coatomer_E PF04733.14 ETO28581.1 - 0.0075 15.7 0.2 0.47 9.8 0.0 2.3 2 0 0 2 2 2 1 Coatomer epsilon subunit ANAPC3 PF12895.7 ETO28581.1 - 0.025 14.8 6.6 4 7.7 0.5 3.6 2 2 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_10 PF13374.6 ETO28581.1 - 0.079 12.9 1.8 12 5.9 0.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat SAT PF16073.5 ETO28581.1 - 0.12 12.0 0.0 0.22 11.2 0.0 1.3 1 0 0 1 1 1 0 Starter unit:ACP transacylase in aflatoxin biosynthesis PEX11 PF05648.14 ETO28582.1 - 2.4e-22 79.5 3.8 1.4e-20 73.7 3.8 2.0 1 1 0 1 1 1 1 Peroxisomal biogenesis factor 11 (PEX11) RabGAP-TBC PF00566.18 ETO28582.1 - 5.5 6.6 9.8 45 3.6 0.0 2.1 2 0 0 2 2 2 0 Rab-GTPase-TBC domain Cation_ATPase PF13246.6 ETO28583.1 - 1.2e-09 38.1 0.0 3.3e-09 36.7 0.0 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Dynactin_p22 PF07426.11 ETO28584.1 - 0.0042 17.0 4.8 0.0049 16.7 3.6 1.6 1 1 0 1 1 1 1 Dynactin subunit p22 MPS2 PF17060.5 ETO28584.1 - 0.043 13.1 8.1 0.074 12.3 8.1 1.4 1 0 0 1 1 1 0 Monopolar spindle protein 2 Methyltransf_12 PF08242.12 ETO28584.1 - 4.2 8.2 12.2 1.6 9.6 4.5 2.7 1 1 1 2 2 2 0 Methyltransferase domain MMR_HSR1 PF01926.23 ETO28585.1 - 0.00027 21.0 0.3 0.0014 18.7 0.3 2.3 1 1 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO28585.1 - 0.0019 18.1 0.3 0.0098 15.8 0.3 2.2 1 1 0 1 1 1 1 RsgA GTPase AAA_28 PF13521.6 ETO28585.1 - 0.0019 18.4 0.0 0.0052 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Rx_N PF18052.1 ETO28585.1 - 0.0044 17.3 0.4 0.025 14.8 0.4 2.4 1 0 0 1 1 1 1 Rx N-terminal domain ABC_tran PF00005.27 ETO28585.1 - 0.0054 17.2 2.0 0.012 16.1 0.0 2.6 2 1 0 2 2 2 1 ABC transporter DUF815 PF05673.13 ETO28585.1 - 0.012 14.8 0.4 0.04 13.1 0.1 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF815) AAA_29 PF13555.6 ETO28585.1 - 0.013 15.2 0.1 0.03 14.1 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain GTP_EFTU PF00009.27 ETO28585.1 - 0.035 13.6 0.1 0.12 11.9 0.1 1.8 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain Arf PF00025.21 ETO28585.1 - 0.068 12.6 0.8 5.5 6.4 0.2 2.5 2 0 0 2 2 2 0 ADP-ribosylation factor family AAA_16 PF13191.6 ETO28585.1 - 0.1 13.0 0.1 0.67 10.3 0.1 2.4 2 0 0 2 2 2 0 AAA ATPase domain ATP_bind_1 PF03029.17 ETO28585.1 - 0.11 12.3 2.2 1.2 8.8 0.1 3.0 2 1 1 3 3 3 0 Conserved hypothetical ATP binding protein AAA_19 PF13245.6 ETO28585.1 - 0.28 11.5 2.0 0.67 10.3 0.1 2.5 3 0 0 3 3 3 0 AAA domain AAA_23 PF13476.6 ETO28585.1 - 0.47 10.9 0.0 0.47 10.9 0.0 3.3 3 1 0 3 3 3 0 AAA domain DNA_repr_REX1B PF14966.6 ETO28585.1 - 0.72 10.6 9.1 9.7 6.9 0.3 4.8 3 2 1 4 4 4 0 DNA repair REX1-B WD40 PF00400.32 ETO28586.1 - 4e-46 154.0 12.7 1.3e-08 35.3 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28586.1 - 1.2e-20 73.5 2.9 3.7e-05 23.9 0.0 5.4 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28586.1 - 5.3e-15 55.2 1.1 0.0003 19.8 0.0 5.5 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO28586.1 - 3e-10 40.3 0.4 0.00041 20.3 0.1 3.3 1 1 0 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO28586.1 - 5.4e-08 32.6 0.6 2.7 8.0 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO28586.1 - 3.9e-07 29.1 2.4 0.0097 14.6 0.2 3.5 2 1 2 4 4 4 2 Nucleoporin Nup120/160 DPPIV_N PF00930.21 ETO28586.1 - 1.2e-05 24.3 0.4 0.33 9.7 0.0 4.5 1 1 4 5 5 5 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Utp8 PF10395.9 ETO28586.1 - 6.4e-05 21.7 0.6 0.11 11.0 0.0 2.1 1 1 1 2 2 2 2 Utp8 family Cytochrom_D1 PF02239.16 ETO28586.1 - 0.00024 19.8 0.0 0.00042 19.0 0.0 1.5 1 1 0 1 1 1 1 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO28586.1 - 0.00028 20.0 1.4 0.0063 15.6 1.4 2.6 1 1 0 1 1 1 1 Coatomer WD associated region WD40_like PF17005.5 ETO28586.1 - 0.0008 18.8 1.4 0.0048 16.3 1.4 2.2 1 1 0 1 1 1 1 WD40-like domain Proteasome_A_N PF10584.9 ETO28586.1 - 0.003 17.2 3.5 34 4.2 0.0 5.4 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 ETO28586.1 - 0.018 14.0 2.5 0.24 10.3 0.1 2.8 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO28586.1 - 0.036 14.1 1.5 8.4 6.5 0.0 3.8 2 2 3 5 5 5 0 Family of unknown function (DUF5570) DUF5046 PF16465.5 ETO28586.1 - 0.1 12.0 0.0 1.4 8.3 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) Colicin_Ia PF11504.8 ETO28586.1 - 0.2 11.8 1.1 54 4.0 0.0 3.9 5 0 0 5 5 4 0 Colicin Ia 2OG-FeII_Oxy PF03171.20 ETO28587.1 - 4.2e-08 33.6 0.7 6e-08 33.1 0.1 1.5 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ETO28588.1 - 1.4e-15 58.1 0.0 2.6e-15 57.2 0.0 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETO28588.1 - 1.4e-05 25.5 0.1 4.2e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily Kelch_4 PF13418.6 ETO28590.1 - 1.3e-06 28.3 0.8 0.00082 19.3 0.0 3.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO28590.1 - 3e-06 27.1 1.9 0.039 13.9 0.1 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO28590.1 - 4.3e-05 23.6 5.8 0.16 12.3 0.1 4.4 4 1 1 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO28590.1 - 0.00012 21.6 1.7 0.22 11.1 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO28590.1 - 0.0023 17.8 6.6 0.087 12.8 0.2 4.1 4 0 0 4 4 4 1 Kelch motif Sld7_C PF18596.1 ETO28591.1 - 0.037 14.2 5.2 0.087 13.0 5.2 1.6 1 0 0 1 1 1 0 Sld7 C-terminal domain TMEM43 PF07787.12 ETO28591.1 - 1.4 8.2 9.7 2.6 7.4 9.7 1.4 1 0 0 1 1 1 0 Transmembrane protein 43 SURF2 PF05477.11 ETO28591.1 - 2.4 7.8 22.9 3.2 7.4 22.9 1.2 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) BTB PF00651.31 ETO28592.1 - 3.8e-17 62.5 0.0 7.6e-17 61.6 0.0 1.5 1 1 0 1 1 1 1 BTB/POZ domain BTB_2 PF02214.22 ETO28592.1 - 0.052 13.9 0.0 0.094 13.1 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain Esterase PF00756.20 ETO28593.1 - 0.028 14.1 0.1 0.042 13.5 0.1 1.4 1 0 0 1 1 1 0 Putative esterase Abhydrolase_1 PF00561.20 ETO28593.1 - 0.071 12.7 0.7 0.36 10.4 0.0 2.0 1 1 1 2 2 2 0 alpha/beta hydrolase fold PX PF00787.24 ETO28594.1 - 2.3e-12 46.9 1.0 2.9e-12 46.6 1.0 1.2 1 0 0 1 1 1 1 PX domain Ribophorin_I PF04597.14 ETO28595.1 - 1.9e-57 195.4 0.6 2.5e-57 195.1 0.6 1.1 1 0 0 1 1 1 1 Ribophorin I DUF4173 PF13777.6 ETO28595.1 - 0.12 11.8 1.3 0.17 11.3 1.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4173) PRY PF13765.6 ETO28596.1 - 0.052 13.2 0.4 0.14 11.8 0.0 2.0 2 0 0 2 2 2 0 SPRY-associated domain EVI2A PF05399.11 ETO28596.1 - 0.073 12.7 3.4 0.14 11.7 3.3 1.6 1 1 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) SUIM_assoc PF16619.5 ETO28596.1 - 0.42 10.7 6.0 1.4 9.1 6.0 1.9 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 RRM_1 PF00076.22 ETO28599.1 - 2.7e-23 81.6 0.0 1.7e-17 63.0 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO28599.1 - 9.8e-05 22.3 0.1 0.0046 16.9 0.0 2.4 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ETO28599.1 - 0.084 12.7 0.0 9 6.2 0.0 2.5 2 0 0 2 2 2 0 Occluded RNA-recognition motif DUF4808 PF16066.5 ETO28599.1 - 0.27 11.8 1.8 0.36 11.4 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4808) Glyco_transf_92 PF01697.27 ETO28600.1 - 4.3e-17 62.6 3.8 4.3e-17 62.6 3.8 2.4 2 1 0 2 2 2 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO28600.1 - 1.5e-07 31.8 0.6 5.5e-07 30.0 0.6 1.9 1 0 0 1 1 1 1 Glycosyl transferase family 2 Ureide_permease PF07168.11 ETO28603.1 - 2.2 7.0 6.0 3.5 6.3 6.0 1.3 1 0 0 1 1 1 0 Ureide permease C_GCAxxG_C_C PF09719.10 ETO28604.1 - 0.041 14.2 0.2 0.059 13.6 0.2 1.4 1 0 0 1 1 1 0 Putative redox-active protein (C_GCAxxG_C_C) AMPKBI PF04739.15 ETO28604.1 - 0.14 12.4 1.1 0.18 12.1 0.2 1.7 2 0 0 2 2 2 0 5'-AMP-activated protein kinase beta subunit, interaction domain VWA_2 PF13519.6 ETO28605.1 - 8.7e-13 48.9 0.2 3.9e-12 46.8 0.1 2.1 2 0 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETO28605.1 - 3e-12 47.2 0.1 5.6e-12 46.2 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO28605.1 - 0.0035 17.3 0.1 0.0094 15.9 0.1 1.7 1 1 0 1 1 1 1 von Willebrand factor type A domain Sporozoite_P67 PF05642.11 ETO28607.1 - 0.048 11.7 5.9 0.051 11.7 5.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Hamartin PF04388.12 ETO28607.1 - 1.2 7.7 6.7 1.3 7.6 6.7 1.0 1 0 0 1 1 1 0 Hamartin protein Secretin_N_2 PF07655.13 ETO28607.1 - 6.1 7.5 12.0 2 9.0 9.4 1.6 1 1 1 2 2 2 0 Secretin N-terminal domain zf-C2H2 PF00096.26 ETO28608.1 - 1.2e-07 31.7 12.0 0.0014 19.0 1.0 3.6 3 0 0 3 3 3 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO28608.1 - 0.019 15.8 15.3 0.27 12.2 0.8 4.4 3 1 0 3 3 3 0 C2H2-type zinc finger CpXC PF14353.6 ETO28608.1 - 0.44 10.6 3.7 11 6.1 0.2 2.5 2 0 0 2 2 2 0 CpXC protein C5HCH PF17982.1 ETO28608.1 - 2.3 8.4 7.9 3.2 8.0 0.0 3.4 3 0 0 3 3 3 0 NSD Cys-His rich domain zf-C2H2_6 PF13912.6 ETO28608.1 - 4.6 7.4 6.6 6.1 7.0 0.7 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger PRIMA1 PF16101.5 ETO28609.1 - 0.061 13.4 4.8 0.15 12.1 4.8 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 ANAPC5 PF12862.7 ETO28609.1 - 0.098 12.7 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 5 TraI_2 PF07514.11 ETO28609.1 - 0.12 11.3 0.0 0.24 10.3 0.0 1.5 1 0 0 1 1 1 0 Putative helicase Pex14_N PF04695.13 ETO28609.1 - 0.2 12.3 13.9 0.58 10.8 2.1 2.3 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Cid2 PF09774.9 ETO28609.1 - 0.21 12.0 4.8 0.27 11.7 3.2 2.0 2 0 0 2 2 2 0 Caffeine-induced death protein 2 CSG2 PF16965.5 ETO28609.1 - 0.21 10.5 1.5 0.54 9.1 1.5 1.6 1 0 0 1 1 1 0 Ceramide synthase regulator DUF4834 PF16118.5 ETO28609.1 - 0.21 12.5 6.7 5.9 7.9 4.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CAP_N PF01213.19 ETO28609.1 - 0.51 9.8 15.1 0.036 13.5 7.6 2.1 2 0 0 2 2 2 0 Adenylate cyclase associated (CAP) N terminal Striatin PF08232.12 ETO28609.1 - 0.75 10.4 6.5 0.64 10.6 1.1 2.3 2 0 0 2 2 2 0 Striatin family DUF3306 PF11748.8 ETO28609.1 - 1.2 10.0 3.4 1.6 9.6 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3306) Tim54 PF11711.8 ETO28609.1 - 6.1 5.5 6.2 5.1 5.8 1.4 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Mito_fiss_reg PF05308.11 ETO28609.1 - 7.2 6.6 15.6 1 9.4 9.2 2.2 2 0 0 2 2 2 0 Mitochondrial fission regulator PI3_PI4_kinase PF00454.27 ETO28610.1 - 1.3e-70 238.1 0.2 2.6e-70 237.1 0.2 1.6 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FAT PF02259.23 ETO28610.1 - 1.1e-67 228.7 17.2 1.1e-67 228.7 17.2 1.8 2 0 0 2 2 2 1 FAT domain FRB_dom PF08771.11 ETO28610.1 - 6.1e-36 122.8 1.7 6.1e-36 122.8 1.7 3.7 3 0 0 3 3 2 1 FKBP12-rapamycin binding domain DUF3385 PF11865.8 ETO28610.1 - 1.4e-26 93.3 0.0 1.4e-26 93.3 0.0 6.2 6 2 3 9 9 9 1 Domain of unknown function (DUF3385) HEAT_2 PF13646.6 ETO28610.1 - 3.4e-13 49.8 1.5 0.0019 18.5 0.1 6.1 6 0 0 6 6 5 3 HEAT repeats FATC PF02260.20 ETO28610.1 - 4.4e-13 48.8 0.4 1.4e-12 47.2 0.4 1.9 1 0 0 1 1 1 1 FATC domain IFRD PF05004.13 ETO28610.1 - 3.2e-07 29.7 7.1 0.0062 15.7 0.2 5.1 3 2 2 5 5 5 2 Interferon-related developmental regulator (IFRD) HEAT_EZ PF13513.6 ETO28610.1 - 5.3e-07 30.0 1.4 3.6 8.2 0.0 7.6 6 1 1 7 7 6 1 HEAT-like repeat HEAT PF02985.22 ETO28610.1 - 5.9e-06 26.1 13.9 0.11 12.8 0.1 9.7 11 0 0 11 11 9 1 HEAT repeat Cnd1 PF12717.7 ETO28610.1 - 8.7e-06 25.9 7.4 2.3 8.2 0.0 6.7 5 1 1 6 6 6 2 non-SMC mitotic condensation complex subunit 1 Tti2 PF10521.9 ETO28610.1 - 0.0096 15.5 13.8 0.14 11.6 0.1 4.5 3 1 2 5 5 5 2 Tti2 family CLASP_N PF12348.8 ETO28610.1 - 0.026 14.1 8.9 0.28 10.7 0.9 5.0 3 2 1 5 5 5 0 CLASP N terminal RTP1_C1 PF10363.9 ETO28610.1 - 0.094 12.9 0.8 4.7 7.4 0.0 3.5 2 0 0 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO28610.1 - 0.13 13.0 0.0 21 6.2 0.0 4.5 2 0 0 2 2 2 0 PBS lyase HEAT-like repeat TPR_1 PF00515.28 ETO28610.1 - 0.2 11.6 2.9 4.9 7.1 0.1 3.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TIP120 PF08623.10 ETO28610.1 - 0.24 11.2 5.8 2 8.2 0.0 4.5 4 1 1 5 5 5 0 TATA-binding protein interacting (TIP20) UTP15_C PF09384.10 ETO28610.1 - 0.48 10.1 4.1 4.7 6.9 0.3 3.7 3 0 0 3 3 3 0 UTP15 C terminal TPR_2 PF07719.17 ETO28610.1 - 0.83 9.9 7.1 3.2 8.1 0.2 4.3 4 0 0 4 4 3 0 Tetratricopeptide repeat MMS19_C PF12460.8 ETO28610.1 - 1 8.4 16.8 0.89 8.6 0.1 4.5 3 1 1 4 4 4 0 RNAPII transcription regulator C-terminal Mg_trans_NIPA PF05653.14 ETO28612.1 - 4.8e-08 32.5 1.8 4.8e-08 32.5 1.8 1.7 2 1 0 2 2 2 1 Magnesium transporter NIPA ArsP_2 PF11449.8 ETO28612.1 - 0.0088 15.3 1.0 0.12 11.5 0.1 2.2 2 0 0 2 2 2 2 Putative, 10TM heavy-metal exporter Mg_trans_NIPA PF05653.14 ETO28613.1 - 1.6e-12 47.1 0.3 2.3e-12 46.6 0.3 1.2 1 0 0 1 1 1 1 Magnesium transporter NIPA EamA PF00892.20 ETO28613.1 - 0.00025 21.2 3.6 0.00039 20.6 3.6 1.3 1 0 0 1 1 1 1 EamA-like transporter family TMEM234 PF10639.9 ETO28613.1 - 0.0061 16.6 0.2 0.014 15.5 0.2 1.7 1 0 0 1 1 1 1 Putative transmembrane family 234 AAA_15 PF13175.6 ETO28613.1 - 0.019 14.7 9.3 0.025 14.3 9.3 1.1 1 0 0 1 1 1 0 AAA ATPase domain EmrE PF13536.6 ETO28613.1 - 0.079 12.5 2.7 0.11 12.1 2.7 1.3 1 0 0 1 1 1 0 Putative multidrug resistance efflux transporter Hydrolase_6 PF13344.6 ETO28613.1 - 0.11 12.6 2.2 0.25 11.4 2.2 1.7 1 1 0 1 1 1 0 Haloacid dehalogenase-like hydrolase Zip PF02535.22 ETO28613.1 - 0.6 9.3 3.0 0.66 9.1 0.0 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter MitMem_reg PF13012.6 ETO28614.1 - 3.8e-16 59.5 0.1 5e-16 59.1 0.1 1.1 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function Secretin_N_2 PF07655.13 ETO28615.1 - 0.59 10.7 66.0 1.6 9.3 18.1 4.4 4 0 0 4 4 4 0 Secretin N-terminal domain Pex2_Pex12 PF04757.14 ETO28615.1 - 1.3 8.6 15.2 0.52 9.9 0.7 2.9 2 1 0 2 2 2 0 Pex2 / Pex12 amino terminal region ALMT PF11744.8 ETO28615.1 - 2.2 7.0 23.1 0.72 8.6 16.4 2.3 2 0 0 2 2 2 0 Aluminium activated malate transporter Ras PF00071.22 ETO28616.1 - 4e-34 117.6 0.0 4.9e-34 117.3 0.0 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO28616.1 - 2.9e-12 46.8 0.0 5.2e-12 46.0 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO28616.1 - 0.00069 19.1 0.0 0.00086 18.8 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Usp PF00582.26 ETO28617.1 - 6.6e-15 55.9 1.1 1.5e-14 54.7 1.1 1.7 1 1 0 1 1 1 1 Universal stress protein family YusW PF14039.6 ETO28617.1 - 0.039 14.5 0.3 0.052 14.1 0.3 1.1 1 0 0 1 1 1 0 YusW-like protein MarC PF01914.17 ETO28617.1 - 0.092 12.1 0.0 0.099 12.0 0.0 1.1 1 0 0 1 1 1 0 MarC family integral membrane protein FTR1 PF03239.14 ETO28617.1 - 0.11 11.6 0.1 0.17 11.0 0.1 1.2 1 0 0 1 1 1 0 Iron permease FTR1 family Tfb4 PF03850.14 ETO28618.1 - 4.7e-16 59.1 0.1 6.7e-16 58.6 0.1 1.2 1 0 0 1 1 1 1 Transcription factor Tfb4 Tfb4 PF03850.14 ETO28619.1 - 1.8e-27 96.5 2.2 2.4e-27 96.1 2.2 1.2 1 0 0 1 1 1 1 Transcription factor Tfb4 SOBP PF15279.6 ETO28620.1 - 3.9e-05 24.4 3.9 5.2e-05 24.0 3.9 1.2 1 0 0 1 1 1 1 Sine oculis-binding protein SUIM_assoc PF16619.5 ETO28621.1 - 0.02 14.9 12.4 0.054 13.6 12.4 1.8 1 1 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 DUF2353 PF09789.9 ETO28623.1 - 1.3e-05 24.7 10.2 1.3e-05 24.7 10.2 4.7 2 2 3 5 5 5 2 Uncharacterized coiled-coil protein (DUF2353) APG6_N PF17675.1 ETO28623.1 - 5e-05 23.8 29.4 5e-05 23.8 29.4 6.8 2 2 4 6 6 6 3 Apg6 coiled-coil region Striatin PF08232.12 ETO28623.1 - 0.01 16.5 16.6 0.01 16.5 16.6 5.3 3 1 1 4 4 4 0 Striatin family TPR_MLP1_2 PF07926.12 ETO28623.1 - 0.014 15.5 27.7 0.014 15.5 27.7 6.4 4 2 3 7 7 7 0 TPR/MLP1/MLP2-like protein Cep57_MT_bd PF06657.13 ETO28623.1 - 0.024 15.1 1.4 0.024 15.1 1.4 9.0 6 2 4 10 10 10 0 Centrosome microtubule-binding domain of Cep57 Pox_A_type_inc PF04508.12 ETO28623.1 - 0.024 14.5 16.3 6.5 6.8 2.2 5.5 4 1 0 4 4 4 0 Viral A-type inclusion protein repeat HJURP_C PF12347.8 ETO28623.1 - 9.6 6.3 16.7 0.44 10.6 0.1 4.5 4 1 1 5 5 5 0 Holliday junction regulator protein family C-terminal repeat DAGAT PF03982.13 ETO28625.1 - 1.3e-76 257.4 5.6 1.7e-52 178.2 0.1 3.1 1 1 2 3 3 3 3 Diacylglycerol acyltransferase DUF4085 PF13315.6 ETO28625.1 - 0.075 12.7 0.0 0.16 11.6 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) FYVE PF01363.21 ETO28628.1 - 1.6e-10 41.0 15.8 1.6e-10 41.0 15.8 1.8 2 0 0 2 2 2 1 FYVE zinc finger GGDEF PF00990.21 ETO28630.1 - 6.3e-11 42.3 6.7 1.3e-07 31.5 0.3 4.1 2 1 2 4 4 4 4 Diguanylate cyclase, GGDEF domain NodZ PF05830.11 ETO28631.1 - 4.9e-08 32.2 1.0 2.1e-06 26.8 0.0 2.7 3 0 0 3 3 3 2 Nodulation protein Z (NodZ) DUF1289 PF06945.13 ETO28631.1 - 0.46 10.3 2.0 7.1 6.5 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1289) Aldedh PF00171.22 ETO28633.1 - 9.3e-135 449.7 0.0 8.6e-88 294.9 0.0 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family LuxC PF05893.14 ETO28633.1 - 0.1 11.6 0.2 0.27 10.2 0.2 1.8 1 1 0 1 1 1 0 Acyl-CoA reductase (LuxC) SRR1 PF07985.12 ETO28634.1 - 6e-07 29.4 0.0 2.2e-05 24.4 0.0 2.5 2 0 0 2 2 2 2 SRR1 RhoGEF PF00621.20 ETO28635.1 - 2.1e-18 67.2 5.6 3.6e-18 66.5 5.6 1.4 1 0 0 1 1 1 1 RhoGEF domain CARD PF00619.21 ETO28635.1 - 0.093 12.8 1.7 3.5 7.7 0.2 2.9 3 0 0 3 3 3 0 Caspase recruitment domain Toast_rack_N PF17115.5 ETO28635.1 - 0.12 12.7 5.3 0.049 13.9 2.5 1.7 2 0 0 2 2 2 0 N-terminal domain of toast_rack, DUF2154 GPR_Gpa2_C PF11970.8 ETO28636.1 - 0.71 10.0 6.8 0.25 11.4 0.9 2.4 2 0 0 2 2 2 0 G protein-coupled glucose receptor regulating Gpa2 C-term DUF4834 PF16118.5 ETO28636.1 - 2.3 9.3 7.1 2.2 9.3 1.8 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) ABC2_membrane PF01061.24 ETO28637.1 - 3.8e-34 118.0 12.5 3.8e-34 118.0 12.5 2.1 3 0 0 3 3 3 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO28637.1 - 1.3e-08 34.4 1.5 2e-08 33.8 1.5 1.3 1 0 0 1 1 1 1 ABC-2 family transporter protein Baculo_E66 PF04850.12 ETO28637.1 - 0.022 13.5 1.3 0.14 10.9 0.1 2.5 2 1 1 3 3 3 0 Baculovirus E66 occlusion-derived virus envelope protein DUF1691 PF07950.11 ETO28637.1 - 0.15 12.8 1.4 0.17 12.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1691) SAM_2 PF07647.17 ETO28639.1 - 8.1e-09 35.5 0.0 2.4e-08 34.0 0.0 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) zf-C2H2_4 PF13894.6 ETO28639.1 - 3.1e-08 33.8 23.0 0.069 14.0 2.2 5.0 4 0 0 4 4 4 3 C2H2-type zinc finger SAM_1 PF00536.30 ETO28639.1 - 7.4e-08 32.7 0.1 2.1e-07 31.2 0.0 1.9 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) DUF629 PF04780.12 ETO28639.1 - 8e-07 27.9 18.2 0.00019 20.1 0.9 4.2 4 0 0 4 4 4 2 Protein of unknown function (DUF629) zf-C2H2 PF00096.26 ETO28639.1 - 2.6e-05 24.4 5.6 0.0016 18.8 3.3 4.7 4 0 0 4 4 3 2 Zinc finger, C2H2 type zf-C2H2_2 PF12756.7 ETO28639.1 - 0.00013 22.3 20.6 0.16 12.3 1.4 4.5 4 0 0 4 4 4 3 C2H2 type zinc-finger (2 copies) zf-C2H2_3rep PF18868.1 ETO28639.1 - 0.00018 22.1 18.4 0.0032 18.2 1.0 4.8 4 1 1 5 5 5 2 Zinc finger C2H2-type, 3 repeats zf-C2H2_6 PF13912.6 ETO28639.1 - 0.001 19.0 18.2 0.053 13.5 0.0 4.7 5 0 0 5 5 4 2 C2H2-type zinc finger zf-Di19 PF05605.12 ETO28639.1 - 0.0085 16.4 0.3 0.0085 16.4 0.3 4.3 4 0 0 4 4 4 2 Drought induced 19 protein (Di19), zinc-binding zf_ZIC PF18366.1 ETO28639.1 - 0.0097 16.0 9.1 0.037 14.2 0.1 3.1 3 0 0 3 3 2 2 Zic proteins zinc finger domain zf-H2C2_2 PF13465.6 ETO28639.1 - 0.013 15.9 19.5 1.4 9.5 0.4 5.5 4 1 0 4 4 4 0 Zinc-finger double domain zf-C2H2_11 PF16622.5 ETO28639.1 - 0.048 13.4 18.9 0.28 11.0 0.1 4.9 4 1 0 4 4 4 0 zinc-finger C2H2-type zinc_ribbon_10 PF10058.9 ETO28639.1 - 0.35 10.6 6.9 11 5.8 0.1 3.5 3 0 0 3 3 3 0 Predicted integral membrane zinc-ribbon metal-binding protein PGBA_N PF15436.6 ETO28639.1 - 0.36 10.4 4.3 0.13 11.9 0.2 2.2 3 0 0 3 3 3 0 Plasminogen-binding protein pgbA N-terminal FOXP-CC PF16159.5 ETO28639.1 - 1.4 9.6 7.7 58 4.4 0.2 4.3 3 1 1 4 4 4 0 FOXP coiled-coil domain zf-C2H2_9 PF16293.5 ETO28639.1 - 1.8 8.5 5.4 7.8 6.4 0.4 3.5 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) Prok-RING_1 PF14446.6 ETO28639.1 - 4.3 7.3 7.6 1 9.3 0.4 3.1 3 0 0 3 3 3 0 Prokaryotic RING finger family 1 Fer4_11 PF13247.6 ETO28639.1 - 8 6.7 7.8 4.4 7.5 1.2 3.1 3 0 0 3 3 3 0 4Fe-4S dicluster domain zinc_ribbon_4 PF13717.6 ETO28639.1 - 8.4 6.4 9.0 0.24 11.3 0.2 2.8 3 0 0 3 3 3 0 zinc-ribbon domain Hydrolase_4 PF12146.8 ETO28641.1 - 6.8e-19 68.1 0.7 9.9e-19 67.5 0.7 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO28641.1 - 1.8e-06 27.8 0.1 3.3e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO28641.1 - 0.017 15.7 0.0 0.023 15.3 0.0 1.2 1 0 0 1 1 1 0 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ETO28641.1 - 0.14 11.7 0.0 0.16 11.6 0.0 1.3 1 0 0 1 1 1 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_3 PF07859.13 ETO28641.1 - 0.18 11.6 0.0 0.31 10.9 0.0 1.3 1 0 0 1 1 1 0 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO28642.1 - 1.4e-24 86.7 0.0 1.7e-24 86.5 0.0 1.1 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO28642.1 - 0.0016 18.1 0.1 0.0019 17.9 0.1 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETO28642.1 - 0.002 17.7 0.3 0.0035 16.8 0.3 1.5 1 1 0 1 1 1 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ETO28642.1 - 0.0027 17.4 0.0 0.0033 17.0 0.0 1.2 1 0 0 1 1 1 1 X-Pro dipeptidyl-peptidase (S15 family) DLH PF01738.18 ETO28642.1 - 0.0096 15.5 0.0 0.012 15.1 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Sugar_tr PF00083.24 ETO28643.1 - 8.7e-35 120.4 25.3 6e-18 64.9 3.5 2.4 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETO28643.1 - 1e-29 103.6 14.2 1.7e-20 73.3 2.5 2.2 2 0 0 2 2 2 2 Major Facilitator Superfamily MFS_2 PF13347.6 ETO28643.1 - 3.5e-05 22.6 17.8 0.002 16.7 2.9 3.4 3 1 0 3 3 3 3 MFS/sugar transport protein MFS_3 PF05977.13 ETO28643.1 - 0.0012 17.4 0.4 0.0012 17.4 0.4 2.1 2 1 0 2 2 2 1 Transmembrane secretion effector DUF4781 PF16013.5 ETO28643.1 - 0.037 12.9 0.0 0.082 11.7 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) UQ_con PF00179.26 ETO28644.1 - 2.1e-10 40.4 0.0 4.1e-10 39.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme NOA36 PF06524.12 ETO28644.1 - 0.4 10.0 6.7 0.53 9.5 6.7 1.1 1 0 0 1 1 1 0 NOA36 protein Calpain_inhib PF00748.19 ETO28644.1 - 0.46 11.0 10.1 0.89 10.1 10.1 1.4 1 0 0 1 1 1 0 Calpain inhibitor Acyl-thio_N PF12590.8 ETO28644.1 - 1 9.9 8.0 1.7 9.2 8.0 1.3 1 0 0 1 1 1 0 Acyl-ATP thioesterase DUF4250 PF14056.6 ETO28645.1 - 0.0016 18.4 11.1 0.055 13.4 0.1 5.0 3 1 0 4 4 4 2 Domain of unknown function (DUF4250) DUF438 PF04282.13 ETO28645.1 - 0.34 10.9 11.2 0.6 10.1 0.6 4.1 4 0 0 4 4 4 0 Family of unknown function (DUF438) PilJ PF13675.6 ETO28645.1 - 1 9.4 13.6 2.8 8.0 0.7 4.2 1 1 4 5 5 5 0 Type IV pili methyl-accepting chemotaxis transducer N-term FUSC-like PF12805.7 ETO28645.1 - 3.4 6.7 14.9 31 3.5 10.8 3.2 1 1 1 2 2 2 0 FUSC-like inner membrane protein yccS SpecificRecomb PF10136.9 ETO28645.1 - 4.6 5.4 10.0 1.2 7.4 7.1 1.5 1 1 0 1 1 1 0 Site-specific recombinase CAP_GLY PF01302.25 ETO28646.1 - 2.2e-08 34.0 0.5 6.8e-08 32.4 0.5 1.8 1 0 0 1 1 1 1 CAP-Gly domain Menin PF05053.13 ETO28646.1 - 2.8 6.2 12.5 4.5 5.5 12.5 1.2 1 0 0 1 1 1 0 Menin REPA_OB_2 PF16900.5 ETO28648.1 - 4.2e-07 29.8 0.1 7.4e-07 29.0 0.1 1.4 1 0 0 1 1 1 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ETO28648.1 - 0.00025 21.0 0.0 0.74 9.8 0.0 2.6 3 1 0 3 3 3 2 OB-fold nucleic acid binding domain DUF223 PF02721.14 ETO28648.1 - 0.0031 17.8 0.1 0.0073 16.6 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function DUF223 CodY PF06018.14 ETO28648.1 - 0.05 13.1 0.3 0.066 12.7 0.3 1.2 1 0 0 1 1 1 0 CodY GAF-like domain Cu-oxidase_2 PF07731.14 ETO28650.1 - 1e-09 38.2 3.6 7.7e-09 35.4 0.8 3.0 3 0 0 3 3 3 1 Multicopper oxidase BRX PF08381.11 ETO28651.1 - 0.028 13.8 3.0 0.076 12.4 3.0 1.8 1 0 0 1 1 1 0 Transcription factor regulating root and shoot growth via Pin3 HU-CCDC81_bac_2 PF18175.1 ETO28651.1 - 0.038 13.9 1.1 0.087 12.7 0.1 2.0 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 DUF2185 PF09951.9 ETO28651.1 - 0.072 12.9 0.1 0.22 11.4 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2185) WWE PF02825.20 ETO28654.1 - 3.9e-06 27.4 1.4 6.7e-05 23.4 1.4 2.3 1 1 0 1 1 1 1 WWE domain Porin_OmpL1 PF11389.8 ETO28654.1 - 0.1 11.8 0.1 0.16 11.2 0.1 1.2 1 0 0 1 1 1 0 Leptospira porin protein OmpL1 Syntaxin PF00804.25 ETO28654.1 - 0.16 11.6 4.0 0.36 10.5 4.0 1.5 1 0 0 1 1 1 0 Syntaxin PH PF00169.29 ETO28655.1 - 1.2e-15 57.9 5.9 9.7e-07 29.3 0.1 3.8 3 0 0 3 3 3 3 PH domain PH_11 PF15413.6 ETO28655.1 - 7.8e-05 23.1 5.0 1.9 9.0 0.4 3.8 3 0 0 3 3 3 3 Pleckstrin homology domain PBP1_TM PF14812.6 ETO28655.1 - 1.4 9.3 20.5 0.91 9.9 1.3 2.7 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF3384 PF11864.8 ETO28656.1 - 0.015 14.2 0.1 0.026 13.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3384) TMEM154 PF15102.6 ETO28656.1 - 0.75 9.7 4.2 6.8 6.6 0.3 2.5 2 0 0 2 2 2 0 TMEM154 protein family DUF4834 PF16118.5 ETO28656.1 - 1.4 9.9 5.4 8.7 7.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Arm PF00514.23 ETO28657.1 - 3.2 7.9 6.8 44 4.3 0.0 4.3 4 2 1 5 5 5 0 Armadillo/beta-catenin-like repeat V-ATPase_H_N PF03224.14 ETO28658.1 - 9.1e-05 21.9 3.9 0.00013 21.4 3.9 1.3 1 0 0 1 1 1 1 V-ATPase subunit H Pyr_redox_2 PF07992.14 ETO28659.1 - 2e-09 37.1 0.0 2.7e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase NAD_binding_9 PF13454.6 ETO28659.1 - 0.064 13.2 0.0 0.47 10.4 0.0 2.4 3 0 0 3 3 3 0 FAD-NAD(P)-binding Thi4 PF01946.17 ETO28659.1 - 0.13 11.4 0.0 0.51 9.5 0.0 1.9 2 0 0 2 2 2 0 Thi4 family NAD_binding_8 PF13450.6 ETO28659.1 - 0.16 12.2 0.0 0.41 10.9 0.0 1.7 1 0 0 1 1 1 0 NAD(P)-binding Rossmann-like domain Bestrophin PF01062.21 ETO28660.1 - 0.045 13.1 0.4 0.045 13.1 0.4 1.5 1 1 1 2 2 2 0 Bestrophin, RFP-TM, chloride channel ComR_TPR PF18710.1 ETO28661.1 - 0.015 14.8 2.5 0.029 13.9 2.5 1.5 1 0 0 1 1 1 0 ComR tetratricopeptide DUF4619 PF15398.6 ETO28661.1 - 0.067 12.7 3.3 0.058 12.9 0.4 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4619) Sec1 PF00995.23 ETO28662.1 - 4.6e-32 112.0 0.0 5.2e-32 111.8 0.0 1.0 1 0 0 1 1 1 1 Sec1 family QIL1 PF15884.5 ETO28662.1 - 0.019 15.5 0.2 0.042 14.4 0.2 1.7 1 1 0 1 1 1 0 MICOS complex subunit MIC13, QIL1 Crl PF07417.12 ETO28662.1 - 0.13 12.3 1.7 0.24 11.5 1.7 1.4 1 0 0 1 1 1 0 Sigma factor-binding transcriptional regulator Crl Trm112p PF03966.16 ETO28664.1 - 8.1e-08 32.7 0.0 3.1e-07 30.9 0.0 2.0 1 1 0 1 1 1 1 Trm112p-like protein Cwf_Cwc_15 PF04889.12 ETO28664.1 - 0.028 14.2 18.2 0.037 13.8 18.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Zip PF02535.22 ETO28664.1 - 0.24 10.6 2.9 0.28 10.3 2.9 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO28664.1 - 0.25 10.1 6.1 0.3 9.8 6.1 1.1 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO28664.1 - 0.42 8.8 21.0 0.57 8.3 21.0 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO28664.1 - 0.89 8.8 19.0 1.3 8.3 19.0 1.1 1 0 0 1 1 1 0 BUD22 NOA36 PF06524.12 ETO28664.1 - 1.1 8.6 21.2 1.6 8.0 21.2 1.2 1 0 0 1 1 1 0 NOA36 protein DUF4175 PF13779.6 ETO28664.1 - 1.4 6.8 11.4 1.8 6.4 11.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF5523 PF17661.1 ETO28664.1 - 1.4 8.5 16.4 2 8.0 16.4 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Pox_Ag35 PF03286.14 ETO28664.1 - 2.8 7.7 17.1 5.3 6.8 17.1 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF4746 PF15928.5 ETO28664.1 - 3.4 7.0 11.8 4.7 6.5 11.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) FYDLN_acid PF09538.10 ETO28664.1 - 3.6 8.3 23.6 11 6.8 23.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) RNA_pol_Rpc4 PF05132.14 ETO28664.1 - 5.3 7.5 8.6 8.4 6.8 8.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 V_ATPase_I PF01496.19 ETO28664.1 - 8.4 4.2 10.5 12 3.7 10.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Sec1 PF00995.23 ETO28665.1 - 8.5e-45 154.0 3.4 1.1e-44 153.7 3.4 1.1 1 0 0 1 1 1 1 Sec1 family DUF3686 PF12458.8 ETO28665.1 - 0.026 13.0 0.6 0.04 12.4 0.6 1.2 1 0 0 1 1 1 0 ATPase involved in DNA repair DUF505 PF04458.12 ETO28665.1 - 0.072 11.5 0.2 0.1 11.0 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF505) HDC PF02329.16 ETO28665.1 - 0.085 11.9 0.0 0.12 11.4 0.0 1.2 1 0 0 1 1 1 0 Histidine carboxylase PI chain Peptidase_S9 PF00326.21 ETO28666.1 - 1.8e-51 174.7 0.0 9e-51 172.3 0.0 1.9 2 0 0 2 2 2 1 Prolyl oligopeptidase family Peptidase_S15 PF02129.18 ETO28666.1 - 2.3e-11 43.8 0.2 1.4e-10 41.3 0.2 2.2 2 1 0 2 2 2 1 X-Pro dipeptidyl-peptidase (S15 family) DPPIV_N PF00930.21 ETO28666.1 - 5.8e-11 41.8 0.2 8.5e-11 41.2 0.2 1.2 1 0 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Esterase PF00756.20 ETO28666.1 - 1.5e-07 31.3 0.2 2.2e-06 27.5 0.2 2.2 1 1 0 1 1 1 1 Putative esterase Hydrolase_4 PF12146.8 ETO28666.1 - 1.7e-05 24.2 0.1 0.00018 20.9 0.0 2.1 2 0 0 2 2 2 1 Serine aminopeptidase, S33 DLH PF01738.18 ETO28666.1 - 5.2e-05 22.9 0.0 0.077 12.5 0.0 2.3 2 0 0 2 2 2 2 Dienelactone hydrolase family Abhydrolase_6 PF12697.7 ETO28666.1 - 0.00024 21.8 0.0 0.00036 21.2 0.0 1.3 1 0 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETO28666.1 - 0.00089 19.0 0.3 0.028 14.0 0.0 2.8 3 0 0 3 3 3 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ETO28666.1 - 0.0075 16.1 0.1 0.18 11.5 0.0 2.3 2 0 0 2 2 2 1 Phospholipase/Carboxylesterase Peptidase_S28 PF05577.12 ETO28666.1 - 0.009 14.9 0.0 0.013 14.4 0.0 1.3 1 0 0 1 1 1 1 Serine carboxypeptidase S28 AXE1 PF05448.12 ETO28666.1 - 0.015 14.0 0.1 0.093 11.4 0.1 2.1 1 1 0 1 1 1 0 Acetyl xylan esterase (AXE1) Esterase_phd PF10503.9 ETO28666.1 - 0.02 14.4 0.1 0.079 12.4 0.0 1.8 2 0 0 2 2 2 0 Esterase PHB depolymerase Presenilin PF01080.17 ETO28667.1 - 0.093 11.5 12.5 0.0086 14.9 4.6 2.0 2 0 0 2 2 2 0 Presenilin Pex14_N PF04695.13 ETO28667.1 - 0.18 12.5 1.1 7.6 7.2 1.1 2.1 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region MMU163 PF17119.5 ETO28667.1 - 1.6 7.8 6.4 0.29 10.3 0.7 2.0 2 0 0 2 2 2 0 Mitochondrial protein up-regulated during meiosis Tim54 PF11711.8 ETO28667.1 - 2.1 7.1 7.8 6.4 5.5 3.3 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CPSF100_C PF13299.6 ETO28667.1 - 2.4 8.3 8.7 17 5.5 0.2 2.2 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal MORN PF02493.20 ETO28668.1 - 1.3e-11 43.6 25.1 0.0048 16.7 1.1 5.2 5 0 0 5 5 5 5 MORN repeat ATP_bind_1 PF03029.17 ETO28670.1 - 9.9e-71 238.3 0.0 5.3e-69 232.7 0.0 2.1 1 1 0 1 1 1 1 Conserved hypothetical ATP binding protein GTP_EFTU PF00009.27 ETO28670.1 - 0.00051 19.6 0.0 0.0014 18.2 0.0 1.8 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_18 PF13238.6 ETO28670.1 - 0.008 16.7 1.0 0.044 14.3 0.0 2.5 3 0 0 3 3 3 1 AAA domain CLP1_P PF16575.5 ETO28670.1 - 0.01 15.6 0.0 0.033 14.0 0.0 1.8 1 0 0 1 1 1 0 mRNA cleavage and polyadenylation factor CLP1 P-loop AAA_30 PF13604.6 ETO28670.1 - 0.011 15.5 0.0 0.019 14.7 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ETO28670.1 - 0.012 16.0 0.0 0.39 11.1 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO28670.1 - 0.015 15.5 0.0 0.063 13.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO28670.1 - 0.026 14.9 0.0 0.075 13.4 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain AAA_7 PF12775.7 ETO28670.1 - 0.036 13.6 0.0 0.077 12.5 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region ABC_tran PF00005.27 ETO28670.1 - 0.072 13.6 0.1 0.29 11.7 0.0 2.0 3 0 0 3 3 2 0 ABC transporter DUF815 PF05673.13 ETO28670.1 - 0.094 11.9 0.0 0.18 10.9 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF815) CBF PF03914.17 ETO28670.1 - 0.13 12.3 0.1 1.1 9.3 0.1 2.0 2 0 0 2 2 2 0 CBF/Mak21 family Cytidylate_kin PF02224.18 ETO28670.1 - 0.14 11.9 0.1 0.27 10.9 0.1 1.4 1 0 0 1 1 1 0 Cytidylate kinase Sigma54_activat PF00158.26 ETO28670.1 - 0.17 11.6 0.0 0.27 10.9 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain FAM176 PF14851.6 ETO28670.1 - 0.57 9.8 4.9 0.63 9.7 0.6 2.1 2 0 0 2 2 2 0 FAM176 family CobT PF06213.12 ETO28670.1 - 0.94 8.8 13.7 4.8 6.5 8.9 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 ETO28670.1 - 4.5 6.6 13.5 9.3 5.6 13.5 1.4 1 1 0 1 1 1 0 SDA1 PPR_2 PF13041.6 ETO28671.1 - 1.3e-05 25.3 10.2 0.14 12.4 0.1 5.0 5 0 0 5 5 5 2 PPR repeat family PPR PF01535.20 ETO28671.1 - 0.022 15.0 4.2 17 5.9 0.0 4.7 5 0 0 5 5 5 0 PPR repeat PPR_3 PF13812.6 ETO28671.1 - 0.059 13.5 0.1 25 5.0 0.0 3.2 2 1 0 2 2 2 0 Pentatricopeptide repeat domain ubiquitin PF00240.23 ETO28672.1 - 1.6e-18 66.2 0.0 2.5e-18 65.6 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_4 PF18036.1 ETO28672.1 - 1.4e-10 41.1 0.1 9.1e-07 28.9 0.0 2.2 1 1 1 2 2 2 2 Ubiquitin-like domain Rad60-SLD PF11976.8 ETO28672.1 - 1.6e-09 37.5 0.1 2.3e-09 36.9 0.1 1.3 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO28672.1 - 1.9e-05 25.1 0.0 3.2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin-like domain UBX PF00789.20 ETO28672.1 - 0.043 14.0 0.0 0.078 13.2 0.0 1.3 1 0 0 1 1 1 0 UBX domain MORN PF02493.20 ETO28673.1 - 1.7e-18 65.3 20.1 4.2e-07 29.5 1.1 3.7 3 0 0 3 3 3 3 MORN repeat APG6_N PF17675.1 ETO28673.1 - 0.0029 18.1 1.8 0.0029 18.1 1.8 1.9 2 0 0 2 2 2 1 Apg6 coiled-coil region Tropomyosin_1 PF12718.7 ETO28673.1 - 0.014 15.5 5.6 0.029 14.5 5.6 1.5 1 0 0 1 1 1 0 Tropomyosin like FapA PF03961.13 ETO28673.1 - 0.22 10.1 7.5 0.41 9.2 7.5 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A CW_binding_1 PF01473.20 ETO28673.1 - 0.31 11.5 1.8 1.6 9.2 1.8 2.2 1 0 0 1 1 1 0 Putative cell wall binding repeat CCDC-167 PF15188.6 ETO28673.1 - 0.62 10.4 3.3 1.5 9.2 3.3 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF4446 PF14584.6 ETO28673.1 - 5.6 6.9 7.1 1.9 8.5 3.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) GCD14 PF08704.10 ETO28673.1 - 6.6 6.3 8.5 14 5.3 2.4 2.2 1 1 1 2 2 2 0 tRNA methyltransferase complex GCD14 subunit DUF2258 PF10015.9 ETO28674.1 - 0.074 13.2 0.8 0.13 12.5 0.8 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2258) He_PIG_assoc PF10632.9 ETO28675.1 - 0.12 12.1 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 He_PIG associated, NEW1 domain of bacterial glycohydrolase IBN_N PF03810.19 ETO28676.1 - 1.9e-05 24.5 0.1 6.2e-05 22.8 0.0 1.9 1 1 1 2 2 2 1 Importin-beta N-terminal domain RIH_assoc PF08454.11 ETO28676.1 - 0.0066 16.3 0.1 0.0077 16.1 0.1 1.1 1 0 0 1 1 1 1 RyR and IP3R Homology associated CLASP_N PF12348.8 ETO28676.1 - 0.072 12.6 0.0 0.19 11.3 0.0 1.6 1 1 0 1 1 1 0 CLASP N terminal Nrap_D2 PF17403.2 ETO28676.1 - 0.11 12.2 0.1 0.15 11.9 0.1 1.1 1 0 0 1 1 1 0 Nrap protein PAP/OAS-like domain Connexin PF00029.19 ETO28677.1 - 0.0045 16.8 6.0 0.0045 16.8 6.0 4.6 3 1 1 4 4 4 1 Connexin DUF4834 PF16118.5 ETO28677.1 - 0.021 15.8 0.0 0.021 15.8 0.0 6.4 4 2 1 5 5 5 0 Domain of unknown function (DUF4834) MscS_TM PF12794.7 ETO28677.1 - 0.26 10.1 0.2 0.66 8.8 0.2 1.7 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 SPATA48 PF15073.6 ETO28677.1 - 0.54 10.6 11.8 0.019 15.3 4.9 2.1 2 0 0 2 2 2 0 Spermatogenesis-associated protein 48 FANCD2OS PF15124.6 ETO28677.1 - 3.6 7.8 5.9 4.1 7.6 3.0 2.5 2 0 0 2 2 2 0 FANCD2 opposite strand protein PIEZO PF15917.5 ETO28678.1 - 3.6 7.0 15.3 4.4 6.7 15.3 1.2 1 0 0 1 1 1 0 Piezo Nop53 PF07767.11 ETO28678.1 - 4.7 6.5 32.7 5.6 6.3 32.7 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) DUF3381 PF11861.8 ETO28678.1 - 6.3 6.6 33.7 8.5 6.1 33.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3381) Mpp10 PF04006.12 ETO28678.1 - 8.2 4.7 35.1 8.7 4.6 35.1 1.0 1 0 0 1 1 1 0 Mpp10 protein DUF2722 PF10846.8 ETO28679.1 - 9.6e-05 21.5 11.0 9.6e-05 21.5 11.0 3.3 4 0 0 4 4 4 1 Protein of unknown function (DUF2722) TFIIA PF03153.13 ETO28679.1 - 0.0034 17.5 18.9 0.0034 17.5 18.9 2.6 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Phage_Mu_F PF04233.14 ETO28679.1 - 0.044 14.5 6.9 1.4 9.7 4.9 2.7 2 0 0 2 2 2 0 Phage Mu protein F like protein DUF2052 PF09747.9 ETO28679.1 - 3.8 7.6 30.5 2.1 8.4 5.7 3.6 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Menin PF05053.13 ETO28680.1 - 4.4 5.5 22.5 6.6 5.0 22.5 1.2 1 0 0 1 1 1 0 Menin SET PF00856.28 ETO28681.1 - 8.4e-06 26.3 0.1 0.077 13.4 0.0 2.3 1 1 1 2 2 2 2 SET domain AWS PF17907.1 ETO28681.1 - 1.4e-05 25.0 18.4 1.4e-05 25.0 18.4 2.1 2 0 0 2 2 2 1 AWS domain DUF3439 PF11921.8 ETO28682.1 - 0.23 11.4 8.5 1.3 9.0 7.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Arm PF00514.23 ETO28683.1 - 1.3e-06 28.2 0.2 0.00047 20.1 0.0 3.1 3 1 0 3 3 3 2 Armadillo/beta-catenin-like repeat Rtt106_N PF18215.1 ETO28683.1 - 0.071 12.9 0.0 0.15 11.8 0.0 1.5 1 0 0 1 1 1 0 Histone chaperone Rtt106 N-terminal domain Cyclin_C PF02984.19 ETO28684.1 - 0.047 13.8 0.6 0.055 13.5 0.6 1.1 1 0 0 1 1 1 0 Cyclin, C-terminal domain RNA_pol_Rpb1_3 PF04983.18 ETO28684.1 - 0.086 12.8 1.1 0.089 12.7 1.1 1.0 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 Cadherin_tail PF15974.5 ETO28684.1 - 0.11 12.8 0.4 0.12 12.7 0.4 1.1 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region Importin_rep_6 PF18829.1 ETO28685.1 - 0.0031 17.6 3.6 0.0075 16.4 3.6 1.6 1 0 0 1 1 1 1 Importin repeat 6 CDC45 PF02724.14 ETO28685.1 - 0.11 10.8 16.1 0.18 10.1 16.1 1.3 1 0 0 1 1 1 0 CDC45-like protein CENP-B_dimeris PF09026.10 ETO28685.1 - 0.2 12.1 12.3 0.34 11.3 12.3 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO28685.1 - 0.25 11.0 12.1 0.049 13.3 8.1 1.8 2 0 0 2 2 2 0 FAM176 family GOLD_2 PF13897.6 ETO28685.1 - 0.37 11.3 5.6 0.77 10.3 5.6 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking NOA36 PF06524.12 ETO28685.1 - 0.41 9.9 11.5 0.67 9.2 11.5 1.3 1 0 0 1 1 1 0 NOA36 protein PI3K_1B_p101 PF10486.9 ETO28685.1 - 0.44 8.3 6.2 0.55 8.0 6.2 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Cytomega_UL84 PF06284.11 ETO28685.1 - 0.5 8.8 5.8 0.68 8.3 5.8 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein PPL5 PF18168.1 ETO28685.1 - 0.52 9.6 5.1 0.94 8.7 5.1 1.4 1 0 0 1 1 1 0 Prim-pol family 5 Astro_capsid_p PF12226.8 ETO28685.1 - 0.53 9.4 15.9 1.9 7.5 13.3 2.1 2 0 0 2 2 2 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 ETO28685.1 - 0.76 7.8 12.4 1.1 7.3 12.4 1.2 1 0 0 1 1 1 0 DNA polymerase phi HMG_box PF00505.19 ETO28685.1 - 1.3 9.5 14.4 0.085 13.3 5.3 3.2 3 0 0 3 3 3 0 HMG (high mobility group) box Zip PF02535.22 ETO28685.1 - 1.8 7.7 6.2 1.3 8.2 4.8 1.5 2 0 0 2 2 2 0 ZIP Zinc transporter TP53IP5 PF15331.6 ETO28685.1 - 4.6 7.3 13.3 0.11 12.6 6.9 1.5 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 PBP1_TM PF14812.6 ETO28685.1 - 4.7 7.7 19.1 0.039 14.3 10.0 2.2 3 0 0 3 3 3 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 ETO28685.1 - 5 5.1 9.8 2.4 6.2 8.0 1.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Metallophos PF00149.28 ETO28686.1 - 1.1e-12 48.9 0.0 1.5e-12 48.4 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO28686.1 - 1e-10 42.1 0.1 5.9e-10 39.6 0.1 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain HIGH_NTase1 PF05636.11 ETO28686.1 - 0.038 13.2 0.0 0.059 12.6 0.0 1.2 1 0 0 1 1 1 0 HIGH Nucleotidyl Transferase Metallophos_3 PF14582.6 ETO28686.1 - 0.069 12.5 0.1 3.6 6.8 0.0 2.5 2 0 0 2 2 2 0 Metallophosphoesterase, calcineurin superfamily FAM176 PF14851.6 ETO28686.1 - 0.082 12.6 1.0 0.15 11.7 1.0 1.4 1 0 0 1 1 1 0 FAM176 family Thioredoxin PF00085.20 ETO28688.1 - 3.9e-64 213.1 0.0 2.6e-30 104.4 0.0 3.4 3 0 0 3 3 3 3 Thioredoxin Thioredoxin_6 PF13848.6 ETO28688.1 - 4e-32 111.6 0.1 1.3e-21 77.4 0.0 3.2 2 1 1 3 3 3 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ETO28688.1 - 2.7e-15 56.8 0.2 9.6e-06 26.0 0.0 4.1 3 1 0 3 3 3 2 Thioredoxin-like domain Thioredoxin_7 PF13899.6 ETO28688.1 - 4.9e-12 45.8 0.0 8.6e-05 22.7 0.0 2.9 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_8 PF13905.6 ETO28688.1 - 1.5e-08 34.8 0.0 0.079 13.3 0.0 4.2 3 1 1 4 4 4 2 Thioredoxin-like AhpC-TSA PF00578.21 ETO28688.1 - 5.4e-08 32.8 0.2 0.0061 16.5 0.0 3.1 2 1 0 2 2 2 2 AhpC/TSA family OST3_OST6 PF04756.13 ETO28688.1 - 6.3e-07 29.0 0.0 0.0022 17.4 0.0 3.1 3 0 0 3 3 3 2 OST3 / OST6 family, transporter family Redoxin PF08534.10 ETO28688.1 - 0.00062 19.5 0.0 0.36 10.5 0.0 2.6 2 0 0 2 2 2 2 Redoxin Thioredoxin_3 PF13192.6 ETO28688.1 - 0.032 14.3 0.0 0.45 10.6 0.0 2.8 4 0 0 4 4 4 0 Thioredoxin domain DSBA PF01323.20 ETO28688.1 - 0.11 12.3 0.2 24 4.7 0.0 3.5 3 1 1 4 4 4 0 DSBA-like thioredoxin domain Thioredoxin_4 PF13462.6 ETO28688.1 - 0.12 12.5 0.6 13 5.9 0.1 2.8 2 1 0 2 2 2 0 Thioredoxin W2 PF02020.18 ETO28688.1 - 0.15 12.2 0.3 0.87 9.8 0.1 2.3 2 0 0 2 2 2 0 eIF4-gamma/eIF5/eIF2-epsilon DUF455 PF04305.14 ETO28689.1 - 3.6e-58 197.0 0.0 4.3e-58 196.8 0.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF455) DUF2018 PF09442.10 ETO28689.1 - 0.22 12.5 0.2 1.6 9.8 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF2018) Motile_Sperm PF00635.26 ETO28691.1 - 0.0015 18.3 1.7 0.0038 17.1 0.1 2.6 3 0 0 3 3 3 1 MSP (Major sperm protein) domain CAMSAP_CH PF11971.8 ETO28691.1 - 0.0039 17.0 0.1 0.011 15.5 0.1 1.8 1 0 0 1 1 1 1 CAMSAP CH domain Transglut_C PF00927.22 ETO28691.1 - 0.018 15.1 0.0 0.44 10.7 0.0 2.9 2 0 0 2 2 2 0 Transglutaminase family, C-terminal ig like domain Peptidase_U32_C PF16325.5 ETO28691.1 - 0.042 14.1 0.0 0.2 12.0 0.0 2.2 2 0 0 2 2 2 0 Peptidase family U32 C-terminal domain CH_2 PF06294.11 ETO28691.1 - 0.085 13.0 0.0 0.26 11.4 0.0 1.8 1 0 0 1 1 1 0 CH-like domain in sperm protein ULD PF16534.5 ETO28693.1 - 0.037 14.1 0.1 0.037 14.1 0.1 2.7 3 0 0 3 3 3 0 Ubiquitin-like oligomerisation domain of SATB COG5 PF10392.9 ETO28694.1 - 0.23 11.6 6.6 0.31 11.2 0.1 3.1 3 0 0 3 3 3 0 Golgi transport complex subunit 5 SpecificRecomb PF10136.9 ETO28694.1 - 0.9 7.8 2.8 1.2 7.4 0.1 1.9 2 0 0 2 2 2 0 Site-specific recombinase Fib_alpha PF08702.10 ETO28694.1 - 0.91 9.7 15.3 2.4 8.3 1.6 3.3 3 0 0 3 3 3 0 Fibrinogen alpha/beta chain family SOGA PF11365.8 ETO28694.1 - 1.3 10.2 19.6 16 6.7 4.7 3.7 2 1 1 3 3 3 0 Protein SOGA DUF4446 PF14584.6 ETO28694.1 - 2.2 8.2 13.3 0.09 12.8 0.7 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) DUF4094 PF13334.6 ETO28694.1 - 4.7 7.7 17.2 2.3 8.7 0.7 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF4094) NAP PF00956.18 ETO28694.1 - 9.8 5.3 17.1 5.4 6.1 3.9 2.3 2 0 0 2 2 2 0 Nucleosome assembly protein (NAP) DUF4349 PF14257.6 ETO28695.1 - 0.098 12.1 1.3 0.17 11.3 1.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Pkinase PF00069.25 ETO28696.1 - 2.3e-06 27.2 2.9 0.0041 16.5 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28696.1 - 0.0017 17.7 0.0 0.027 13.8 0.0 2.2 2 0 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO28696.1 - 0.011 15.0 0.6 0.025 13.9 0.0 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO28696.1 - 0.028 13.2 0.1 0.028 13.2 0.1 2.5 2 1 1 3 3 3 0 Fungal protein kinase PGA2 PF07543.12 ETO28696.1 - 0.096 12.7 12.3 0.11 12.4 10.5 1.9 2 0 0 2 2 2 0 Protein trafficking PGA2 NST1 PF13945.6 ETO28696.1 - 0.22 11.6 17.8 2.5 8.2 11.3 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF3306 PF11748.8 ETO28696.1 - 0.25 12.2 9.4 0.6 11.0 9.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3306) Presenilin PF01080.17 ETO28696.1 - 0.44 9.2 5.2 0.56 8.9 5.2 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 ETO28696.1 - 0.49 10.4 9.7 0.35 10.9 6.8 2.0 2 0 0 2 2 2 0 Peptidase family S49 N-terminal V_ATPase_I PF01496.19 ETO28696.1 - 0.65 7.8 5.2 0.95 7.3 5.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family PEHE PF15275.6 ETO28696.1 - 1.9 9.2 13.3 0.049 14.3 4.4 2.4 3 1 0 3 3 2 0 PEHE domain DUF4512 PF14975.6 ETO28696.1 - 4 8.3 6.5 2.7 8.9 2.7 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4512) MGC-24 PF05283.11 ETO28696.1 - 4.3 7.8 11.0 0.73 10.3 0.5 2.3 2 0 0 2 2 2 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF1168 PF06658.12 ETO28696.1 - 5.2 6.9 22.1 13 5.6 17.4 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1168) Zip PF02535.22 ETO28696.1 - 5.4 6.1 5.1 9 5.4 5.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Bud13 PF09736.9 ETO28696.1 - 6 7.3 17.0 50 4.3 14.3 2.2 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex FAM176 PF14851.6 ETO28697.1 - 0.0002 21.0 0.8 0.00025 20.7 0.8 1.1 1 0 0 1 1 1 1 FAM176 family EphA2_TM PF14575.6 ETO28697.1 - 0.001 19.9 0.0 0.0013 19.5 0.0 1.2 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain SpoIIIAH PF12685.7 ETO28697.1 - 0.0021 17.9 1.9 0.0026 17.6 1.9 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein GRP PF07172.11 ETO28697.1 - 0.0024 18.5 0.1 0.0033 18.1 0.1 1.1 1 0 0 1 1 1 1 Glycine rich protein family FYDLN_acid PF09538.10 ETO28697.1 - 0.0027 18.4 8.2 0.0036 18.0 8.2 1.4 1 0 0 1 1 1 1 Protein of unknown function (FYDLN_acid) V_ATPase_I PF01496.19 ETO28697.1 - 0.0076 14.2 0.0 0.0082 14.1 0.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family TMEM154 PF15102.6 ETO28697.1 - 0.0086 16.0 0.4 0.012 15.5 0.4 1.2 1 0 0 1 1 1 1 TMEM154 protein family Sporozoite_P67 PF05642.11 ETO28697.1 - 0.0092 14.1 1.9 0.0096 14.1 1.9 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen DUF2749 PF10907.8 ETO28697.1 - 0.013 15.6 0.9 0.051 13.7 0.5 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2749) SID-1_RNA_chan PF13965.6 ETO28697.1 - 0.021 13.3 0.0 0.023 13.1 0.0 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF3357 PF11837.8 ETO28697.1 - 0.058 13.9 0.3 0.086 13.3 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) TFB6 PF17110.5 ETO28697.1 - 0.061 13.1 2.2 0.072 12.8 2.2 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH DUF2457 PF10446.9 ETO28697.1 - 0.065 12.4 22.8 0.083 12.0 22.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SARAF PF06682.12 ETO28697.1 - 0.11 12.1 0.0 0.12 12.0 0.0 1.1 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis RRN3 PF05327.11 ETO28697.1 - 0.12 10.8 8.4 0.14 10.7 8.4 1.0 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 ETO28697.1 - 0.13 11.5 4.6 0.15 11.2 4.6 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Sigma70_ner PF04546.13 ETO28697.1 - 0.15 12.0 8.2 0.16 11.8 8.2 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region RXT2_N PF08595.11 ETO28697.1 - 0.16 12.0 5.6 0.22 11.6 5.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal BUD22 PF09073.10 ETO28697.1 - 0.16 11.3 6.3 0.16 11.3 6.3 1.0 1 0 0 1 1 1 0 BUD22 CobT PF06213.12 ETO28697.1 - 0.79 9.1 9.2 0.97 8.8 9.2 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2076 PF09849.9 ETO28697.1 - 1.1 9.2 11.2 1.3 9.0 11.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) CDC45 PF02724.14 ETO28697.1 - 1.5 7.1 9.7 1.8 6.8 9.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Herpes_LMP1 PF05297.11 ETO28697.1 - 1.6 7.8 7.7 1.9 7.6 7.7 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Rhabdo_ncap PF00945.18 ETO28697.1 - 2 7.2 5.5 2.3 7.0 5.5 1.1 1 0 0 1 1 1 0 Rhabdovirus nucleocapsid protein GCIP PF13324.6 ETO28697.1 - 4.3 6.8 9.2 5.3 6.6 9.2 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF2722 PF10846.8 ETO28697.1 - 5.3 5.9 5.5 5.7 5.8 5.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Pox_Ag35 PF03286.14 ETO28697.1 - 6.3 6.5 9.6 8 6.2 9.6 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DNA_pol_phi PF04931.13 ETO28697.1 - 7.4 4.5 21.5 8.6 4.3 21.5 1.0 1 0 0 1 1 1 0 DNA polymerase phi DUF1736 PF08409.11 ETO28698.1 - 1e-22 79.9 1.6 1e-22 79.9 1.6 2.3 2 0 0 2 2 2 1 Domain of unknown function (DUF1736) Med27 PF11571.8 ETO28699.1 - 0.71 10.3 7.5 0.2 12.1 0.5 3.4 1 1 2 4 4 4 0 Mediator complex subunit 27 Phage_lysozyme PF00959.19 ETO28699.1 - 0.89 10.0 5.0 0.67 10.4 1.3 2.6 3 1 0 3 3 3 0 Phage lysozyme LIM_bind PF01803.16 ETO28701.1 - 0.035 13.6 0.1 0.048 13.2 0.1 1.3 1 0 0 1 1 1 0 LIM-domain binding protein DUF4831 PF16115.5 ETO28701.1 - 0.094 11.7 0.1 0.21 10.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4831) Aft1_HRR PF11787.8 ETO28701.1 - 8 7.7 6.9 2.1 9.6 3.5 1.8 2 1 0 2 2 2 0 Aft1 HRR domain TFIIF_alpha PF05793.12 ETO28702.1 - 1.4 7.4 23.5 0.072 11.7 13.0 2.4 2 0 0 2 2 2 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) MyTH4 PF00784.17 ETO28705.1 - 2.7e-25 89.0 0.0 9.4e-25 87.2 0.0 2.0 1 0 0 1 1 1 1 MyTH4 domain Flot PF15975.5 ETO28705.1 - 0.13 12.5 0.3 0.13 12.5 0.3 2.8 2 1 0 3 3 3 0 Flotillin ABC2_membrane_2 PF12679.7 ETO28706.1 - 0.023 14.0 0.0 0.028 13.7 0.0 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Spt20 PF12090.8 ETO28706.1 - 0.029 14.0 21.6 0.069 12.8 21.6 1.6 1 0 0 1 1 1 0 Spt20 family Eapp_C PF10238.9 ETO28706.1 - 0.055 13.5 6.9 0.13 12.4 6.9 1.6 1 0 0 1 1 1 0 E2F-associated phosphoprotein SelP_N PF04592.14 ETO28706.1 - 0.16 11.3 11.2 0.32 10.4 11.2 1.4 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Band_3_cyto PF07565.13 ETO28706.1 - 0.22 11.3 14.9 0.48 10.2 14.9 1.5 1 0 0 1 1 1 0 Band 3 cytoplasmic domain V_ATPase_I PF01496.19 ETO28706.1 - 0.26 9.2 7.1 0.33 8.8 7.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ETO28706.1 - 0.84 8.3 14.3 1.5 7.5 14.3 1.5 1 0 0 1 1 1 0 Presenilin CLN3 PF02487.17 ETO28706.1 - 3 6.8 6.0 4.1 6.3 6.0 1.2 1 0 0 1 1 1 0 CLN3 protein Zip PF02535.22 ETO28706.1 - 3.2 6.9 5.5 4.6 6.4 5.5 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter P5-ATPase PF12409.8 ETO28706.1 - 3.6 7.7 5.9 8.7 6.5 5.9 1.6 1 0 0 1 1 1 0 P5-type ATPase cation transporter FAM176 PF14851.6 ETO28706.1 - 3.7 7.2 7.4 1.5 8.5 3.6 2.2 2 0 0 2 2 2 0 FAM176 family SLC12 PF03522.15 ETO28706.1 - 5.5 5.9 14.1 8.2 5.3 14.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 SprA-related PF12118.8 ETO28706.1 - 6.9 5.7 25.6 0.058 12.5 14.9 2.2 2 0 0 2 2 2 0 SprA-related family Connexin PF00029.19 ETO28706.1 - 7 6.3 7.7 12 5.6 7.7 1.3 1 0 0 1 1 1 0 Connexin EIIBC-GUT_N PF03612.14 ETO28706.1 - 9.5 5.9 8.8 22 4.8 8.8 1.5 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus F-box-like PF12937.7 ETO28707.1 - 0.0003 20.6 0.1 0.0012 18.6 0.0 2.0 2 0 0 2 2 2 1 F-box-like DUF4962 PF16332.5 ETO28707.1 - 0.0051 15.4 3.4 0.0073 14.9 3.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4962) DUF3271 PF11675.8 ETO28707.1 - 0.03 13.6 0.0 0.075 12.3 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3271) DUF2267 PF10025.9 ETO28707.1 - 0.11 12.7 0.0 1.6 9.0 0.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2267) Myosin_head PF00063.21 ETO28708.1 - 2.1e-106 356.7 4.2 1.9e-104 350.3 4.2 2.1 1 1 0 1 1 1 1 Myosin head (motor domain) UCH_N PF16674.5 ETO28708.1 - 0.13 12.2 0.8 3.6 7.6 0.1 2.7 2 0 0 2 2 2 0 N-terminal of ubiquitin carboxyl-terminal hydrolase 37 AAA_8 PF12780.7 ETO28710.1 - 8e-06 25.4 1.4 2.5e-05 23.7 1.4 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_14 PF13173.6 ETO28710.1 - 6.2e-05 23.0 0.4 0.0011 19.0 0.0 3.1 2 1 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO28710.1 - 0.00011 22.3 0.0 0.00028 20.9 0.0 1.8 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO28710.1 - 0.00013 22.4 0.1 0.00058 20.3 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Viral_helicase1 PF01443.18 ETO28710.1 - 0.0013 18.5 0.1 0.0041 16.9 0.0 1.9 2 0 0 2 2 2 1 Viral (Superfamily 1) RNA helicase DUF2087 PF09860.9 ETO28710.1 - 0.0023 18.0 0.1 0.0067 16.5 0.1 1.8 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2087) AAA_2 PF07724.14 ETO28710.1 - 0.01 15.9 0.2 0.093 12.8 0.0 2.6 3 0 0 3 3 3 0 AAA domain (Cdc48 subfamily) Mg_chelatase PF01078.21 ETO28710.1 - 0.029 13.8 0.2 1.2 8.5 0.0 2.3 1 1 1 2 2 2 0 Magnesium chelatase, subunit ChlI ATPase_2 PF01637.18 ETO28710.1 - 0.036 14.0 1.8 1.7 8.5 0.2 3.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea ABC_tran PF00005.27 ETO28710.1 - 0.054 14.0 0.3 0.19 12.2 0.0 2.1 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ETO28710.1 - 0.056 13.8 0.0 0.18 12.2 0.0 2.0 1 0 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ETO28710.1 - 0.071 13.4 0.4 1.2 9.4 0.0 2.9 2 1 0 2 2 2 0 AAA domain NACHT PF05729.12 ETO28710.1 - 0.16 11.8 2.7 0.65 9.9 0.0 3.1 4 0 0 4 4 4 0 NACHT domain AAA_7 PF12775.7 ETO28711.1 - 0.026 14.1 0.9 0.19 11.2 0.9 2.4 1 1 0 1 1 1 0 P-loop containing dynein motor region AAA_22 PF13401.6 ETO28711.1 - 0.038 14.3 0.0 0.26 11.5 0.0 2.6 1 1 0 1 1 1 0 AAA domain Alpha_Helical PF18489.1 ETO28711.1 - 0.094 12.9 2.8 4.6 7.5 0.0 3.2 3 0 0 3 3 3 0 Alpha helical domain CDC45 PF02724.14 ETO28712.1 - 0.013 13.8 6.4 0.016 13.6 6.4 1.1 1 0 0 1 1 1 0 CDC45-like protein ALMT PF11744.8 ETO28712.1 - 0.28 10.0 3.0 0.3 9.9 3.0 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO28712.1 - 0.96 8.1 5.2 1.2 7.8 5.2 1.1 1 0 0 1 1 1 0 Presenilin Sec62 PF03839.16 ETO28712.1 - 1.2 8.6 3.8 1.6 8.2 3.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Sporozoite_P67 PF05642.11 ETO28712.1 - 1.2 7.2 3.7 1.4 7.0 3.7 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Atg14 PF10186.9 ETO28713.1 - 0.00031 19.9 3.8 0.0005 19.3 3.8 1.3 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Spc7 PF08317.11 ETO28713.1 - 0.0016 17.4 16.3 0.0016 17.4 16.3 1.5 1 1 0 1 1 1 1 Spc7 kinetochore protein ETC_C1_NDUFA5 PF04716.14 ETO28713.1 - 0.01 15.7 0.1 0.041 13.7 0.1 2.1 1 0 0 1 1 1 1 ETC complex I subunit conserved region Exonuc_VII_L PF02601.15 ETO28713.1 - 0.02 14.5 3.9 0.027 14.0 3.9 1.4 1 0 0 1 1 1 0 Exonuclease VII, large subunit TolA_bind_tri PF16331.5 ETO28713.1 - 0.086 12.9 16.5 0.16 12.0 8.3 2.7 1 1 1 2 2 2 0 TolA binding protein trimerisation DUF3450 PF11932.8 ETO28713.1 - 1.5 8.1 15.2 0.19 11.0 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) UPF0242 PF06785.11 ETO28713.1 - 1.6 8.8 27.3 0.48 10.5 23.8 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus DUF1664 PF07889.12 ETO28713.1 - 2.6 8.1 10.8 6.6 6.8 5.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 ETO28713.1 - 2.6 8.4 18.3 2.6 8.4 9.7 2.8 1 1 1 2 2 2 0 Fez1 BST2 PF16716.5 ETO28713.1 - 4.8 7.8 13.8 5 7.8 8.9 2.6 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 CENP-H PF05837.12 ETO28713.1 - 5.6 7.4 13.7 0.87 10.0 9.5 2.0 2 0 0 2 2 1 0 Centromere protein H (CENP-H) NPV_P10 PF05531.12 ETO28713.1 - 7.2 7.2 9.2 10 6.7 4.2 2.8 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein DUF3552 PF12072.8 ETO28713.1 - 7.3 5.9 23.9 1.7 8.0 3.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) SlyX PF04102.12 ETO28713.1 - 8.4 7.1 17.6 6.7 7.4 4.4 3.4 2 1 0 3 3 3 0 SlyX PDEase_I PF00233.19 ETO28714.1 - 2.5e-79 266.4 1.3 2.5e-79 266.4 1.3 2.2 2 1 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase DUF1335 PF07056.11 ETO28715.1 - 0.15 12.2 0.0 0.26 11.4 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1335) MA3 PF02847.17 ETO28716.1 - 2.2e-13 50.2 0.3 2.2e-13 50.2 0.3 2.5 2 0 0 2 2 2 1 MA3 domain BUD22 PF09073.10 ETO28716.1 - 0.0068 15.8 8.8 0.0068 15.8 8.8 2.5 2 0 0 2 2 2 1 BUD22 NPV_P10 PF05531.12 ETO28717.1 - 0.065 13.7 0.2 0.13 12.8 0.2 1.4 1 0 0 1 1 1 0 Nucleopolyhedrovirus P10 protein SR1P PF13790.6 ETO28718.1 - 0.11 12.6 0.5 0.23 11.6 0.5 1.5 1 0 0 1 1 1 0 SR1 protein DUF2757 PF10955.8 ETO28718.1 - 0.19 12.0 1.9 12 6.2 0.1 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2757) TP2 PF01254.18 ETO28718.1 - 9 6.9 12.4 19 5.9 9.8 2.5 1 1 0 1 1 1 0 Nuclear transition protein 2 Acyl-CoA_dh_1 PF00441.24 ETO28719.1 - 3.7e-33 114.8 0.1 5.2e-33 114.4 0.1 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETO28719.1 - 2.7e-20 73.1 0.0 6.5e-20 71.9 0.0 1.6 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_M PF02770.19 ETO28719.1 - 1.2e-12 47.9 0.0 2.8e-12 46.7 0.0 1.6 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, middle domain Acyl-CoA_dh_2 PF08028.11 ETO28719.1 - 4.2e-12 46.5 0.0 6.9e-12 45.8 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Ion_trans PF00520.31 ETO28721.1 - 6.5e-11 41.9 5.1 1.1e-10 41.2 4.9 1.4 1 1 0 1 1 1 1 Ion transport protein SDA1 PF05285.12 ETO28722.1 - 0.018 14.5 30.9 0.23 10.9 11.0 2.3 2 0 0 2 2 2 0 SDA1 Folliculin PF11704.8 ETO28723.1 - 0.00021 21.2 4.5 0.00041 20.3 4.5 1.6 1 1 0 1 1 1 1 Vesicle coat protein involved in Golgi to plasma membrane transport tRNA_bind_2 PF13725.6 ETO28723.1 - 0.014 15.1 5.9 0.024 14.4 5.9 1.3 1 0 0 1 1 1 0 Possible tRNA binding domain mCpol PF18182.1 ETO28723.1 - 0.094 13.1 0.4 0.39 11.1 0.3 2.0 2 0 0 2 2 2 0 minimal CRISPR polymerase domain Allexi_40kDa PF05549.11 ETO28723.1 - 0.096 12.2 1.9 0.15 11.5 1.9 1.3 1 0 0 1 1 1 0 Allexivirus 40kDa protein ALMT PF11744.8 ETO28723.1 - 0.82 8.4 8.2 1 8.1 8.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CobT PF06213.12 ETO28723.1 - 2 7.7 9.3 2.9 7.2 9.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TMEM215 PF15746.5 ETO28724.1 - 0.41 10.1 7.3 0.039 13.4 2.5 1.6 2 0 0 2 2 2 0 TMEM215 family HAGH_C PF16123.5 ETO28727.1 - 6.4e-14 52.2 0.3 3.8e-13 49.8 0.3 2.4 1 1 0 1 1 1 1 Hydroxyacylglutathione hydrolase C-terminus ECH_1 PF00378.20 ETO28727.1 - 1.4e-11 44.2 0.4 3.3e-11 43.0 0.0 1.9 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO28727.1 - 4.7e-06 26.3 0.1 9.7e-06 25.3 0.0 1.6 2 0 0 2 2 2 1 Enoyl-CoA hydratase/isomerase PUF PF00806.19 ETO28728.1 - 2.7e-38 127.5 11.4 5.4e-09 35.3 0.0 5.7 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat CENP-B_dimeris PF09026.10 ETO28728.1 - 0.023 15.1 9.2 0.023 15.1 9.2 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Cwf_Cwc_15 PF04889.12 ETO28728.1 - 0.43 10.3 24.8 0.68 9.6 24.8 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein EHN PF06441.12 ETO28728.1 - 1.2 9.5 4.3 3.3 8.1 4.3 1.7 1 0 0 1 1 1 0 Epoxide hydrolase N terminus Nop14 PF04147.12 ETO28728.1 - 1.3 7.2 25.1 1.7 6.8 25.1 1.1 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO28728.1 - 3.7 6.8 20.9 5.1 6.3 20.9 1.2 1 0 0 1 1 1 0 BUD22 DUF5523 PF17661.1 ETO28728.1 - 5.4 6.6 25.1 8.1 6.0 25.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5523) PPP4R2 PF09184.11 ETO28728.1 - 5.9 6.4 25.0 9.9 5.7 24.5 1.6 2 0 0 2 2 2 0 PPP4R2 Trypan_PARP PF05887.11 ETO28728.1 - 7.5 6.5 11.7 0.57 10.2 0.6 2.2 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) NUDIX PF00293.28 ETO28729.1 - 6.1e-07 29.5 0.0 1.5e-06 28.3 0.0 1.7 1 0 0 1 1 1 1 NUDIX domain TPR_8 PF13181.6 ETO28730.1 - 4.5e-15 54.5 15.4 0.0018 18.4 0.3 6.5 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28730.1 - 6.4e-15 54.0 18.6 0.0035 17.3 1.3 7.4 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28730.1 - 1.4e-11 43.7 19.3 0.00039 20.1 1.4 6.8 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28730.1 - 2.1e-11 44.0 13.2 0.016 15.5 2.5 6.0 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28730.1 - 1.5e-10 40.6 11.8 0.0014 18.2 0.9 5.3 4 1 1 5 5 5 2 TPR repeat TPR_14 PF13428.6 ETO28730.1 - 1.7e-09 37.7 0.8 2.5 9.1 0.0 5.9 4 2 2 6 6 6 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO28730.1 - 3.8e-09 36.9 4.6 0.017 15.6 0.1 5.7 3 1 3 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO28730.1 - 3.2e-06 27.7 0.0 4 8.2 0.1 5.1 5 1 0 5 5 5 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28730.1 - 8.3e-06 25.5 7.6 1.9 8.7 0.3 5.7 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO28730.1 - 2.4e-05 24.7 4.9 0.057 14.1 0.0 4.6 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO28730.1 - 3e-05 23.4 0.1 0.19 10.9 0.1 3.2 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO28730.1 - 4.2e-05 23.6 23.8 0.024 15.0 0.2 6.2 6 1 1 7 7 7 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO28730.1 - 0.002 17.5 3.7 0.084 12.3 0.6 3.5 3 0 0 3 3 3 1 SHNi-TPR TPR_9 PF13371.6 ETO28730.1 - 0.017 15.3 0.9 2.4 8.4 0.0 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO28730.1 - 0.058 13.3 13.5 2.3 8.2 0.1 4.3 5 0 0 5 5 4 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO28730.1 - 0.15 12.3 0.1 0.15 12.3 0.1 4.9 4 1 1 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 Sel1 PF08238.12 ETO28730.1 - 5.7 7.8 5.8 4.6 8.1 0.2 3.6 5 0 0 5 5 3 0 Sel1 repeat TamB PF04357.13 ETO28731.1 - 0.12 11.6 1.8 0.14 11.3 1.8 1.1 1 0 0 1 1 1 0 TamB, inner membrane protein subunit of TAM complex Arc_PepC_II PF06847.11 ETO28731.1 - 0.34 11.5 7.1 0.22 12.0 5.2 1.6 2 0 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Folate_carrier PF01770.18 ETO28731.1 - 8.3 5.0 6.3 9.7 4.8 6.3 1.2 1 0 0 1 1 1 0 Reduced folate carrier RAB3GAP2_N PF14655.6 ETO28732.1 - 1.8e-05 24.2 0.0 2.7e-05 23.6 0.0 1.3 1 0 0 1 1 1 1 Rab3 GTPase-activating protein regulatory subunit N-terminus CENP-B_dimeris PF09026.10 ETO28732.1 - 0.45 10.9 6.7 0.74 10.2 0.7 2.4 2 0 0 2 2 2 0 Centromere protein B dimerisation domain CoA_binding_3 PF13727.6 ETO28733.1 - 0.01 15.8 0.1 0.017 15.2 0.1 1.5 1 0 0 1 1 1 0 CoA-binding domain Dynein_heavy PF03028.15 ETO28733.1 - 0.022 14.8 0.1 0.046 13.8 0.1 1.6 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain AAA_16 PF13191.6 ETO28733.1 - 0.035 14.5 0.2 0.064 13.6 0.2 1.4 1 1 0 1 1 1 0 AAA ATPase domain PgaD PF13994.6 ETO28734.1 - 0.43 10.6 2.8 2.4 8.2 1.2 2.9 3 0 0 3 3 3 0 PgaD-like protein SAM35 PF10806.8 ETO28734.1 - 1.4 9.2 9.2 0.13 12.5 0.7 2.9 3 0 0 3 3 3 0 SAM35, subunit of SAM coomplex SbcD_C PF12320.8 ETO28734.1 - 1.5 9.1 6.2 0.18 12.1 1.2 2.1 2 0 0 2 2 2 0 Type 5 capsule protein repressor C-terminal domain DUF2721 PF11026.8 ETO28734.1 - 4.4 7.2 6.3 1.4 8.8 0.4 3.0 4 0 0 4 4 4 0 Protein of unknown function (DUF2721) SAM_1 PF00536.30 ETO28736.1 - 0.0004 20.8 0.0 0.00078 19.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) TMEM154 PF15102.6 ETO28736.1 - 0.002 18.0 0.4 0.0046 16.9 0.1 1.7 1 1 1 2 2 2 1 TMEM154 protein family SAM_2 PF07647.17 ETO28736.1 - 0.0027 17.8 0.0 0.0045 17.1 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MLANA PF14991.6 ETO28736.1 - 0.054 13.8 0.0 0.09 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein melan-A Adeno_E3_CR2 PF02439.15 ETO28736.1 - 0.06 13.1 0.3 0.1 12.4 0.3 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 DUF4330 PF14221.6 ETO28736.1 - 0.061 13.5 0.5 0.44 10.8 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4330) EphA2_TM PF14575.6 ETO28736.1 - 0.11 13.3 0.5 0.26 12.2 0.5 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Ank_2 PF12796.7 ETO28737.1 - 2e-11 44.3 0.4 3.7e-11 43.4 0.2 1.6 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO28737.1 - 7.9e-11 41.9 2.3 1.3e-07 31.7 0.1 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank_3 PF13606.6 ETO28737.1 - 4.6e-09 35.8 1.9 9.3e-06 25.6 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ETO28737.1 - 2.5e-08 34.3 1.5 1.5e-07 31.8 0.2 2.5 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO28737.1 - 1.9e-07 31.2 0.7 9.6e-05 22.6 0.4 3.1 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Synaptobrevin PF00957.21 ETO28738.1 - 0.00092 19.0 0.0 0.0023 17.7 0.0 1.7 2 0 0 2 2 2 1 Synaptobrevin B9-C2 PF07162.11 ETO28739.1 - 8.5e-29 100.9 0.2 1.3e-28 100.3 0.2 1.3 1 0 0 1 1 1 1 Ciliary basal body-associated, B9 protein Gly_transf_sug PF04488.15 ETO28741.1 - 5.7e-14 52.5 0.2 1.4e-13 51.3 0.2 1.7 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif Caps_synth PF05704.12 ETO28741.1 - 0.0088 15.4 0.0 0.041 13.3 0.0 1.9 1 1 1 2 2 2 1 Capsular polysaccharide synthesis protein GAS PF13851.6 ETO28743.1 - 0.0051 16.2 19.2 0.0051 16.2 19.2 4.3 3 1 0 3 3 3 1 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 ETO28743.1 - 0.012 15.7 24.1 0.012 15.7 24.1 4.5 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0242) N-terminus DUF4407 PF14362.6 ETO28743.1 - 1.1 8.5 36.0 0.44 9.8 2.8 3.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Lsr2 PF11774.8 ETO28743.1 - 2.1 8.5 8.2 0.25 11.5 0.3 3.2 2 1 1 3 3 3 0 Lsr2 DUF410 PF04190.13 ETO28744.1 - 1e-24 87.7 1.1 7e-24 85.0 1.1 2.1 1 1 0 1 1 1 1 Protein of unknown function (DUF410) DUF910 PF06014.11 ETO28744.1 - 0.45 10.6 2.2 3.8 7.6 0.3 2.5 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF910) SPRY PF00622.28 ETO28745.1 - 7.5e-09 35.7 0.0 1.1e-05 25.5 0.0 2.5 2 1 0 2 2 2 2 SPRY domain DUF5393 PF17371.2 ETO28745.1 - 0.076 11.1 0.1 0.14 10.2 0.1 1.3 2 0 0 2 2 2 0 Family of unknown function (DUF5393) Secretin_N_2 PF07655.13 ETO28745.1 - 0.25 11.9 15.6 0.14 12.8 12.4 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain Menin PF05053.13 ETO28745.1 - 3.8 5.8 6.7 5.2 5.3 6.7 1.1 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO28747.1 - 0.085 13.4 36.9 0.51 10.9 5.6 3.2 3 0 0 3 3 3 0 Secretin N-terminal domain FGF-BP1 PF06473.12 ETO28747.1 - 0.23 11.3 3.8 0.59 9.9 0.0 2.3 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) Utp14 PF04615.13 ETO28747.1 - 2.6 6.5 13.1 3.7 6.0 13.1 1.1 1 0 0 1 1 1 0 Utp14 protein dsRBD2 PF17842.1 ETO28747.1 - 5.4 7.2 11.7 8.3 6.6 0.7 3.8 4 0 0 4 4 4 0 Double-stranded RNA binding domain 2 RhoGAP PF00620.27 ETO28748.1 - 1.5e-10 41.1 3.8 8.1e-10 38.7 0.1 2.9 2 1 0 2 2 2 1 RhoGAP domain V_ATPase_I PF01496.19 ETO28748.1 - 0.16 9.8 6.6 0.21 9.5 6.6 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family MID_MedPIWI PF18296.1 ETO28748.1 - 2 8.2 7.5 2.8 7.6 7.3 1.4 1 1 0 1 1 1 0 MID domain of medPIWI Presenilin PF01080.17 ETO28748.1 - 3 6.5 4.4 3.5 6.3 4.4 1.3 1 0 0 1 1 1 0 Presenilin Glyco_transf_22 PF03901.17 ETO28749.1 - 5.3e-37 128.1 22.2 5.3e-37 128.1 22.2 2.2 2 1 0 2 2 2 1 Alg9-like mannosyltransferase family Sulfatase PF00884.23 ETO28750.1 - 1.1e-41 143.2 0.6 3.4e-22 79.2 0.0 2.2 2 0 0 2 2 2 2 Sulfatase Phosphodiest PF01663.22 ETO28750.1 - 3.6e-06 26.8 0.6 0.0042 16.7 0.3 2.3 2 0 0 2 2 2 2 Type I phosphodiesterase / nucleotide pyrophosphatase Glyco_hydro_2_C PF02836.17 ETO28751.1 - 0.008 15.3 0.7 0.046 12.8 0.2 2.3 2 1 0 2 2 2 1 Glycosyl hydrolases family 2, TIM barrel domain Glyco_hydro_2_N PF02837.18 ETO28752.1 - 2.3e-11 43.9 0.9 3.9e-11 43.1 0.9 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 2, sugar binding domain Glyco_hydro_2 PF00703.21 ETO28752.1 - 1.5e-06 28.8 1.0 3e-06 27.8 0.1 2.0 2 0 0 2 2 2 1 Glycosyl hydrolases family 2 BetaGal_dom4_5 PF13364.6 ETO28752.1 - 0.027 15.1 0.9 0.066 13.8 0.9 1.7 1 0 0 1 1 1 0 Beta-galactosidase jelly roll domain SipA PF09052.10 ETO28755.1 - 0.0055 16.3 5.3 0.6 9.7 1.9 2.4 2 1 0 2 2 2 2 SipA N-terminal domain LUC7 PF03194.15 ETO28755.1 - 0.0095 15.6 3.1 0.0095 15.6 3.1 2.1 2 0 0 2 2 2 1 LUC7 N_terminus Peptidase_C65 PF10275.9 ETO28755.1 - 0.013 15.0 2.1 0.013 15.0 2.1 2.0 2 0 0 2 2 2 0 Peptidase C65 Otubain tRNA-synt_His PF13393.6 ETO28755.1 - 0.034 13.4 0.2 0.034 13.4 0.2 2.0 2 0 0 2 2 2 0 Histidyl-tRNA synthetase DUF4633 PF15464.6 ETO28755.1 - 0.075 13.2 2.8 3.6 7.8 1.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4633) Phage_GP20 PF06810.11 ETO28755.1 - 0.27 11.0 12.1 0.023 14.5 5.7 2.1 2 1 1 3 3 3 0 Phage minor structural protein GP20 ALMT PF11744.8 ETO28755.1 - 0.51 9.1 10.7 0.3 9.9 2.1 2.1 2 0 0 2 2 2 0 Aluminium activated malate transporter G-alpha PF00503.20 ETO28755.1 - 0.71 9.0 8.0 0.29 10.2 2.9 2.0 2 0 0 2 2 2 0 G-protein alpha subunit DUF2115 PF09888.9 ETO28755.1 - 1.2 9.7 7.7 0.97 9.9 2.7 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) WASH-7_C PF14746.6 ETO28755.1 - 5 6.8 10.1 2.8 7.6 2.6 2.5 2 1 0 2 2 2 0 WASH complex subunit 7, C-terminal HSCB_C PF07743.13 ETO28755.1 - 8.1 7.0 11.9 1.5 9.3 2.2 3.6 2 2 1 3 3 3 0 HSCB C-terminal oligomerisation domain GPS2_interact PF15784.5 ETO28755.1 - 9.9 6.7 12.5 1.5 9.3 6.4 2.4 2 0 0 2 2 2 0 G-protein pathway suppressor 2-interacting domain DNApol_Exo PF18136.1 ETO28757.1 - 0.0081 15.3 0.9 0.0098 15.1 0.9 1.1 1 0 0 1 1 1 1 DNA mitochondrial polymerase exonuclease domain G-alpha PF00503.20 ETO28758.1 - 6.4e-12 45.3 0.2 1e-11 44.6 0.2 1.3 1 1 0 1 1 1 1 G-protein alpha subunit DUF4834 PF16118.5 ETO28760.1 - 1.9 9.5 5.7 15 6.7 0.2 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TPR_12 PF13424.6 ETO28761.1 - 9.3e-38 128.4 2.2 2e-16 60.0 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO28761.1 - 1.9e-27 94.3 0.2 1.9e-06 27.5 0.0 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28761.1 - 2.5e-26 90.4 23.3 7.1e-08 32.0 1.7 6.1 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28761.1 - 6.7e-26 88.4 4.3 1.9e-06 27.5 0.0 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28761.1 - 3.3e-24 83.0 25.4 1.5e-06 28.0 3.0 5.8 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28761.1 - 3.9e-21 73.4 20.7 4.4e-06 26.4 0.9 5.9 6 0 0 6 6 5 5 Tetratricopeptide repeat SNAP PF14938.6 ETO28761.1 - 2.7e-08 33.6 6.6 2.1e-06 27.4 2.3 2.3 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO28761.1 - 1.2e-06 28.0 19.7 0.0018 17.9 0.5 6.6 4 3 2 6 6 6 3 TPR repeat TPR_16 PF13432.6 ETO28761.1 - 1.4e-05 25.6 0.0 0.054 14.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO28761.1 - 4.1e-05 24.0 0.2 4.3 8.4 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO28761.1 - 4.3e-05 23.4 14.6 0.0094 15.9 0.8 5.0 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO28761.1 - 0.00038 19.9 0.0 0.016 14.6 0.0 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_6 PF13174.6 ETO28761.1 - 0.00044 20.7 5.4 1.7 9.4 0.2 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO28761.1 - 0.0012 18.6 13.0 0.061 13.0 0.8 3.4 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO28761.1 - 0.0013 18.8 9.0 3.4 7.8 0.9 5.1 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO28761.1 - 0.018 15.4 11.3 7.8 7.1 1.4 5.7 5 1 1 6 6 5 0 Tetratricopeptide repeat Fer4_12 PF13353.6 ETO28761.1 - 0.048 13.9 2.0 0.22 11.8 0.1 2.8 2 1 1 3 3 2 0 4Fe-4S single cluster domain DUF627 PF04781.12 ETO28761.1 - 0.054 13.5 3.3 11 6.1 0.0 3.6 3 1 1 4 4 3 0 Protein of unknown function (DUF627) PPR PF01535.20 ETO28761.1 - 0.099 12.9 8.0 9.2 6.8 0.2 4.9 5 0 0 5 5 4 0 PPR repeat PPR_2 PF13041.6 ETO28761.1 - 9.4 6.5 8.8 17 5.7 0.1 4.4 4 0 0 4 4 4 0 PPR repeat family Exo_endo_phos PF03372.23 ETO28762.1 - 0.00032 20.3 0.0 0.00053 19.6 0.0 1.4 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family DUF1699 PF08004.11 ETO28762.1 - 0.0007 19.3 0.5 0.0012 18.5 0.5 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1699) SapB_1 PF05184.15 ETO28763.1 - 0.12 12.4 0.4 0.12 12.4 0.4 2.0 2 0 0 2 2 2 0 Saposin-like type B, region 1 RNase_P_p30 PF01876.16 ETO28764.1 - 4.7e-14 52.4 6.0 4.1e-13 49.3 6.0 2.0 1 1 0 1 1 1 1 RNase P subunit p30 DUF3641 PF12345.8 ETO28764.1 - 0.32 11.0 3.3 0.32 11.0 0.1 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF3641) Glyco_trans_1_4 PF13692.6 ETO28765.1 - 0.04 14.4 0.1 0.079 13.4 0.1 1.4 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_4 PF13439.6 ETO28765.1 - 0.12 12.4 0.0 0.2 11.6 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase Family 4 Glycos_transf_1 PF00534.20 ETO28766.1 - 1.3e-13 50.9 0.0 1.9e-13 50.3 0.0 1.4 1 1 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO28766.1 - 1.4e-11 44.9 0.0 2.3e-11 44.2 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ETO28766.1 - 4.8e-05 23.7 0.0 0.00049 20.4 0.0 2.3 1 1 0 1 1 1 1 Glycosyl transferases group 1 Membr_traf_MHD PF10540.9 ETO28766.1 - 0.028 14.6 0.2 0.086 13.0 0.2 1.7 1 1 0 1 1 1 0 Munc13 (mammalian uncoordinated) homology domain DUF3932 PF13068.6 ETO28766.1 - 0.071 13.4 0.1 0.56 10.5 0.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3932) CNOT1_HEAT PF16418.5 ETO28766.1 - 0.084 13.0 0.1 0.18 11.9 0.1 1.5 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat Presenilin PF01080.17 ETO28768.1 - 0.23 10.2 6.2 0.37 9.5 6.2 1.2 1 0 0 1 1 1 0 Presenilin Methyltransf_12 PF08242.12 ETO28768.1 - 6.3 7.6 10.9 16 6.4 0.4 3.0 3 0 0 3 3 3 0 Methyltransferase domain Secretin_N_2 PF07655.13 ETO28768.1 - 8.2 7.1 25.2 11 6.7 2.1 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain CDC45 PF02724.14 ETO28769.1 - 0.053 11.8 1.1 0.064 11.5 1.1 1.0 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO28769.1 - 0.086 13.0 4.4 0.15 12.2 4.4 1.3 1 1 0 1 1 1 0 YL1 nuclear protein Taxilin PF09728.9 ETO28770.1 - 1.4e-14 54.0 51.5 7e-11 41.9 31.3 3.1 2 1 1 3 3 3 2 Myosin-like coiled-coil protein ComC PF03047.14 ETO28770.1 - 0.015 15.0 0.7 0.043 13.6 0.7 1.8 1 0 0 1 1 1 0 COMC family DSPn PF14671.6 ETO28770.1 - 0.057 13.9 1.4 0.12 12.8 0.6 2.0 1 1 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half GAS PF13851.6 ETO28770.1 - 0.071 12.4 47.0 0.91 8.8 27.6 2.8 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF4250 PF14056.6 ETO28770.1 - 0.52 10.3 3.1 2.3 8.2 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4250) TSC22 PF01166.18 ETO28770.1 - 0.85 10.0 24.9 0.085 13.2 1.5 5.8 4 4 2 6 6 6 0 TSC-22/dip/bun family CTNNBL PF08216.11 ETO28770.1 - 1.5 9.1 17.0 0.095 12.9 1.4 3.3 2 1 1 3 3 3 0 Catenin-beta-like, Arm-motif containing nuclear ArabFuran-catal PF09206.11 ETO28771.1 - 0.0052 16.1 0.2 0.0064 15.8 0.2 1.1 1 0 0 1 1 1 1 Alpha-L-arabinofuranosidase B, catalytic Adipogenin PF15202.6 ETO28771.1 - 0.12 12.4 0.1 0.31 11.1 0.1 1.7 1 0 0 1 1 1 0 Adipogenin TAF1D PF15333.6 ETO28771.1 - 0.2 11.3 8.1 0.019 14.7 2.8 1.8 1 1 1 2 2 2 0 TATA box-binding protein-associated factor 1D MCC-bdg_PDZ PF10506.9 ETO28772.1 - 0.0012 18.8 1.4 0.0084 16.1 1.4 2.5 1 0 0 1 1 1 1 PDZ domain of MCC-2 bdg protein for Usher syndrome FliP PF00813.20 ETO28772.1 - 1.2 8.9 3.9 4 7.3 0.1 2.7 2 0 0 2 2 2 0 FliP family WRNPLPNID PF15017.6 ETO28772.1 - 10 7.1 13.3 18 6.3 1.9 2.9 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box Med26_C PF15693.5 ETO28774.1 - 0.086 13.0 3.5 0.14 12.3 3.5 1.2 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal DPM2 PF07297.12 ETO28775.1 - 8.3e-19 67.7 1.7 1e-18 67.4 1.7 1.1 1 0 0 1 1 1 1 Dolichol phosphate-mannose biosynthesis regulatory protein (DPM2) TMEM174 PF15029.6 ETO28775.1 - 0.0031 17.3 0.6 0.0033 17.2 0.6 1.0 1 0 0 1 1 1 1 Transmembrane protein 174 DHHC PF01529.20 ETO28775.1 - 0.006 16.7 1.8 0.0067 16.5 1.8 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase DUF1240 PF06836.12 ETO28775.1 - 0.007 16.9 1.5 0.0095 16.5 1.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1240) MpPF26 PF07666.11 ETO28775.1 - 0.025 14.7 3.0 0.03 14.4 3.0 1.1 1 0 0 1 1 1 0 M penetrans paralogue family 26 Tetraspanin PF00335.20 ETO28775.1 - 0.071 12.8 1.2 0.092 12.4 1.2 1.2 1 0 0 1 1 1 0 Tetraspanin family Neurensin PF14927.6 ETO28775.1 - 0.14 11.8 0.8 0.73 9.5 0.0 2.0 1 1 1 2 2 2 0 Neurensin Saf_2TM PF18303.1 ETO28775.1 - 0.16 11.5 1.6 0.21 11.2 1.6 1.1 1 0 0 1 1 1 0 SAVED-fused 2TM effector domain RRM_4 PF10598.9 ETO28775.1 - 0.25 11.7 3.2 0.61 10.4 0.1 2.0 1 1 1 2 2 2 0 RNA recognition motif of the spliceosomal PrP8 Sigma_reg_N PF13800.6 ETO28775.1 - 1.9 8.9 8.9 4.5 7.6 1.0 2.2 1 1 1 2 2 2 0 Sigma factor regulator N-terminal UL41A PF17591.2 ETO28775.1 - 3.9 7.7 6.9 5.2 7.2 1.0 2.1 1 1 1 2 2 2 0 Herpesvirus UL41A WD40 PF00400.32 ETO28776.1 - 5.2e-21 74.6 12.1 1.4e-09 38.4 0.2 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28776.1 - 1.1e-09 38.4 0.1 3.2e-05 24.2 0.1 3.7 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28776.1 - 0.0058 15.6 0.5 0.76 8.7 0.0 3.3 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO28776.1 - 0.0099 15.8 0.4 0.23 11.3 0.0 2.6 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PALB2_WD40 PF16756.5 ETO28776.1 - 0.014 14.3 0.7 0.16 10.9 0.1 2.5 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO28776.1 - 0.11 12.5 0.3 0.92 9.5 0.1 2.3 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Frtz PF11768.8 ETO28776.1 - 0.12 10.7 0.0 0.14 10.4 0.0 1.2 1 0 0 1 1 1 0 WD repeat-containing and planar cell polarity effector protein Fritz Chromadorea_ALT PF05535.12 ETO28777.1 - 0.13 12.5 1.8 0.92 9.7 1.8 2.1 1 1 0 1 1 1 0 Chromadorea ALT protein Peptidase_M1_N PF17900.1 ETO28778.1 - 4.9e-31 108.4 0.0 6.3e-31 108.0 0.0 1.1 1 0 0 1 1 1 1 Peptidase M1 N-terminal domain CBM-like PF14683.6 ETO28778.1 - 0.017 15.0 0.1 0.034 14.0 0.1 1.5 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain III Alpha_E3_glycop PF01563.16 ETO28778.1 - 0.54 10.4 0.1 0.54 10.4 0.1 2.2 3 0 0 3 3 3 0 Alphavirus E3 glycoprotein WD40 PF00400.32 ETO28779.1 - 8.4e-66 216.3 20.0 4.7e-10 39.9 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO28779.1 - 3.9e-16 58.9 0.6 0.013 14.5 0.0 6.7 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO28779.1 - 8e-15 54.9 1.9 0.037 14.3 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO28779.1 - 4.6e-11 42.6 3.8 8.9e-05 22.0 0.3 3.1 2 1 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO28779.1 - 1.2e-07 30.6 0.2 0.0021 16.7 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain eIF2A PF08662.11 ETO28779.1 - 2.1e-07 31.0 1.7 0.022 14.7 0.1 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO28779.1 - 1.1e-05 24.3 12.4 0.18 10.4 0.1 5.2 2 2 3 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO28779.1 - 4.6e-05 23.2 3.8 2.6 8.1 0.1 5.3 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat PI-PLC-Y PF00387.19 ETO28779.1 - 0.004 17.5 0.2 0.021 15.2 0.0 2.2 2 1 0 2 2 2 1 Phosphatidylinositol-specific phospholipase C, Y domain DUF2431 PF10354.9 ETO28779.1 - 0.024 14.9 0.0 1.5 9.0 0.0 3.3 1 1 1 2 2 2 0 Domain of unknown function (DUF2431) DUF4999 PF16390.5 ETO28779.1 - 0.027 14.7 3.2 6.3 7.1 0.0 4.4 5 0 0 5 5 5 0 Domain of unknown function Coatomer_WDAD PF04053.14 ETO28779.1 - 0.042 12.9 3.8 0.07 12.2 1.1 2.3 1 1 1 2 2 2 0 Coatomer WD associated region Nbas_N PF15492.6 ETO28779.1 - 0.05 12.9 2.1 6.3 6.0 0.1 3.7 1 1 4 5 5 5 0 Neuroblastoma-amplified sequence, N terminal GATase PF00117.28 ETO28779.1 - 0.089 12.6 0.0 7.8 6.2 0.0 3.0 1 1 2 3 3 3 0 Glutamine amidotransferase class-I Resistin PF06954.11 ETO28779.1 - 0.13 12.8 1.3 32 5.2 0.0 3.7 2 2 2 4 4 4 0 Resistin Peptidase_S66 PF02016.15 ETO28779.1 - 0.14 12.3 0.1 7.7 6.7 0.0 2.6 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain Kelch_1 PF01344.25 ETO28780.1 - 4.4e-06 26.2 4.3 0.03 13.9 0.5 3.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO28780.1 - 2.1e-05 24.4 0.3 0.00021 21.2 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO28780.1 - 8.1e-05 22.8 1.7 0.017 15.4 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO28780.1 - 9.9e-05 22.2 1.3 0.31 11.1 0.2 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO28780.1 - 0.0029 17.5 3.6 0.087 12.8 1.4 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO28780.1 - 0.0062 16.8 0.0 0.049 13.9 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain TFIIA PF03153.13 ETO28781.1 - 0.0059 16.7 9.5 0.0059 16.7 9.5 2.6 2 1 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit NOA36 PF06524.12 ETO28782.1 - 0.99 8.7 17.0 0.24 10.7 10.1 2.2 2 0 0 2 2 2 0 NOA36 protein WD40 PF00400.32 ETO28784.1 - 8.7e-26 89.7 12.6 2.4e-05 25.0 0.1 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28784.1 - 4.3e-07 30.1 0.7 1.5 9.1 0.0 4.7 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO28784.1 - 0.0035 18.0 5.6 0.0035 18.0 5.6 2.6 2 1 0 2 2 2 1 TRAF-type zinc finger UPF0242 PF06785.11 ETO28784.1 - 0.013 15.7 5.2 0.023 14.8 5.2 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Striatin PF08232.12 ETO28784.1 - 0.086 13.4 2.6 0.15 12.6 2.6 1.3 1 0 0 1 1 1 0 Striatin family Myb_DNA-bind_3 PF12776.7 ETO28784.1 - 0.091 13.8 0.9 0.32 12.0 0.9 2.0 1 0 0 1 1 1 0 Myb/SANT-like DNA-binding domain Hira PF07569.11 ETO28784.1 - 0.34 10.6 2.3 2.2 7.9 0.0 3.0 2 2 2 4 4 4 0 TUP1-like enhancer of split ZapB PF06005.12 ETO28784.1 - 2.2 8.8 9.9 9 6.8 9.9 2.0 1 1 0 1 1 1 0 Cell division protein ZapB CDC45 PF02724.14 ETO28785.1 - 0.43 8.8 8.4 0.66 8.2 8.4 1.2 1 0 0 1 1 1 0 CDC45-like protein SMG1 PF15785.5 ETO28787.1 - 0.0048 15.4 0.7 0.0073 14.7 0.7 1.2 1 0 0 1 1 1 1 Serine/threonine-protein kinase smg-1 PKI PF02827.16 ETO28787.1 - 0.13 12.4 3.3 1.3 9.2 2.0 3.2 2 0 0 2 2 2 0 cAMP-dependent protein kinase inhibitor MIF4G PF02854.19 ETO28788.1 - 1.9e-07 31.0 1.3 1.2e-06 28.3 1.3 1.9 1 1 0 1 1 1 1 MIF4G domain tRNA-synt_1 PF00133.22 ETO28789.1 - 1.4e-148 495.9 0.0 3.2e-147 491.4 0.0 2.0 1 1 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) tRNA-synt_1_2 PF13603.6 ETO28789.1 - 1.4e-10 41.0 0.0 6.7e-09 35.5 0.0 2.3 1 1 1 2 2 2 1 Leucyl-tRNA synthetase, Domain 2 tRNA-synt_1g PF09334.11 ETO28789.1 - 2e-10 40.0 0.3 4.6e-07 28.9 0.0 2.9 2 1 0 2 2 2 2 tRNA synthetases class I (M) Jag_N PF14804.6 ETO28789.1 - 0.21 12.0 0.1 0.21 12.0 0.1 2.2 3 0 0 3 3 3 0 Jag N-terminus Lip_prot_lig_C PF10437.9 ETO28790.1 - 0.0026 17.7 0.1 0.0044 17.0 0.1 1.4 1 0 0 1 1 1 1 Bacterial lipoate protein ligase C-terminus Pox_A_type_inc PF04508.12 ETO28790.1 - 0.0056 16.5 0.0 0.013 15.3 0.0 1.6 1 0 0 1 1 1 1 Viral A-type inclusion protein repeat FlaC_arch PF05377.11 ETO28790.1 - 0.044 14.2 0.1 0.084 13.3 0.1 1.5 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) DUF2981 PF11200.8 ETO28790.1 - 0.83 9.3 4.6 0.96 9.1 4.6 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Anticodon_1 PF08264.13 ETO28791.1 - 2.2e-34 118.6 0.1 4.2e-34 117.7 0.1 1.4 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1 PF00133.22 ETO28791.1 - 7.6e-06 24.5 0.0 1e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (I, L, M and V) M11L PF11099.8 ETO28792.1 - 0.046 14.0 0.1 0.069 13.4 0.1 1.2 1 0 0 1 1 1 0 Apoptosis regulator M11L like EamA PF00892.20 ETO28793.1 - 0.00019 21.6 2.3 0.00019 21.6 2.3 2.2 2 0 0 2 2 2 1 EamA-like transporter family COX14 PF14880.6 ETO28793.1 - 0.029 14.2 1.4 0.34 10.8 0.1 2.5 2 0 0 2 2 2 0 Cytochrome oxidase c assembly DUF2207 PF09972.9 ETO28793.1 - 0.25 10.1 1.4 1.7 7.3 0.1 2.1 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) Bromo_TP PF07524.13 ETO28794.1 - 6e-12 45.4 0.1 9.4e-12 44.8 0.1 1.3 1 0 0 1 1 1 1 Bromodomain associated CBFD_NFYB_HMF PF00808.23 ETO28794.1 - 0.0001 22.5 0.1 0.0007 19.8 0.0 2.4 2 1 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone TAF8_C PF10406.9 ETO28794.1 - 0.00013 22.5 2.2 0.00058 20.4 2.2 2.2 1 0 0 1 1 1 1 Transcription factor TFIID complex subunit 8 C-term CENP-T_C PF15511.6 ETO28794.1 - 0.0075 16.4 0.0 0.016 15.4 0.0 1.4 1 0 0 1 1 1 1 Centromere kinetochore component CENP-T histone fold TAF PF02969.17 ETO28794.1 - 0.04 14.1 0.0 0.1 12.8 0.0 1.8 1 1 0 1 1 1 0 TATA box binding protein associated factor (TAF) Histone PF00125.24 ETO28794.1 - 0.13 12.6 0.0 0.13 12.6 0.0 2.2 3 0 0 3 3 3 0 Core histone H2A/H2B/H3/H4 Pox_E2-like PF04497.12 ETO28796.1 - 0.007 14.9 2.3 0.0072 14.8 2.3 1.0 1 0 0 1 1 1 1 Poxviridae protein zf_C2H2_6 PF18450.1 ETO28796.1 - 0.35 10.6 3.7 1.1 9.0 3.7 1.9 1 0 0 1 1 1 0 Zinc Finger domain PHM7_cyt PF14703.6 ETO28798.1 - 0.0066 16.7 1.6 0.019 15.2 1.3 1.8 1 1 0 1 1 1 1 Cytosolic domain of 10TM putative phosphate transporter Tctex-1 PF03645.13 ETO28798.1 - 0.13 12.5 0.7 0.46 10.8 0.6 2.0 1 1 0 1 1 1 0 Tctex-1 family Formyl_trans_C PF02911.18 ETO28800.1 - 0.048 13.9 0.0 0.082 13.2 0.0 1.3 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain PQQ_3 PF13570.6 ETO28800.1 - 0.2 12.2 0.2 12 6.5 0.0 2.7 3 0 0 3 3 3 0 PQQ-like domain ABC2_membrane PF01061.24 ETO28801.1 - 5.5e-35 120.7 20.2 5.5e-35 120.7 20.2 1.6 2 0 0 2 2 2 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO28801.1 - 0.00045 19.4 23.0 0.00045 19.4 23.0 2.1 1 1 0 1 1 1 1 ABC-2 family transporter protein RRM_1 PF00076.22 ETO28802.1 - 2.8e-05 23.9 0.0 6.9e-05 22.6 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MIB_HERC2 PF06701.13 ETO28803.1 - 2e-34 117.6 28.7 3.6e-20 72.0 6.3 5.3 5 0 0 5 5 5 4 Mib_herc2 GP24_25 PF17388.2 ETO28803.1 - 6.7 6.7 7.0 35 4.4 7.0 2.2 1 1 0 1 1 1 0 Tail assembly gene products 24 & 25 LRR_4 PF12799.7 ETO28804.1 - 0.72 10.4 7.0 30 5.2 0.0 4.3 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) RasGEF_N PF00618.20 ETO28805.1 - 8.6e-06 26.0 0.1 8.6e-06 26.0 0.1 4.4 5 1 0 5 5 5 1 RasGEF N-terminal motif Otopetrin PF03189.13 ETO28805.1 - 0.0011 17.8 0.0 0.06 12.2 0.0 2.9 2 1 1 3 3 3 2 Otopetrin DUF966 PF06136.13 ETO28805.1 - 0.0034 17.2 17.9 0.0034 17.2 17.9 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF966) Antimicrobial25 PF16839.5 ETO28805.1 - 3.1 8.0 6.1 2.6 8.2 0.1 3.4 3 1 0 3 3 3 0 Nematode antimicrobial peptide YL1 PF05764.13 ETO28806.1 - 0.0016 18.6 46.3 0.0023 18.1 46.3 1.1 1 0 0 1 1 1 1 YL1 nuclear protein SDA1 PF05285.12 ETO28806.1 - 0.0043 16.5 45.3 0.0071 15.8 45.3 1.4 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO28806.1 - 0.0082 14.4 41.3 0.011 14.0 41.3 1.1 1 0 0 1 1 1 1 Nop14-like family Merozoite_SPAM PF07133.11 ETO28806.1 - 0.0096 15.9 51.7 0.0096 15.9 51.7 1.6 2 0 0 2 2 1 1 Merozoite surface protein (SPAM) CCSAP PF15748.5 ETO28806.1 - 0.017 15.3 33.3 0.025 14.8 33.3 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated LAP1C PF05609.12 ETO28806.1 - 0.071 12.2 21.9 0.085 11.9 21.9 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) CDC45 PF02724.14 ETO28806.1 - 0.14 10.4 42.8 0.2 9.9 42.8 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4604 PF15377.6 ETO28806.1 - 0.33 11.4 45.1 0.48 10.8 45.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) SOBP PF15279.6 ETO28806.1 - 0.35 11.5 21.3 0.45 11.1 21.3 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein Dapper PF15268.6 ETO28806.1 - 0.88 8.3 25.7 0.88 8.3 25.7 1.1 1 0 0 1 1 1 0 Dapper DUF3807 PF12720.7 ETO28806.1 - 1.6 9.0 38.8 3.3 7.9 38.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) GAGA_bind PF06217.12 ETO28806.1 - 3 8.0 27.5 0.28 11.5 22.7 1.7 2 0 0 2 2 2 0 GAGA binding protein-like family Nop53 PF07767.11 ETO28806.1 - 3.8 6.8 50.0 6.1 6.1 50.0 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) GREB1 PF15782.5 ETO28806.1 - 5.8 3.9 22.8 7 3.6 22.8 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Raftlin PF15250.6 ETO28806.1 - 6.1 5.5 22.3 8.5 5.0 22.3 1.2 1 0 0 1 1 1 0 Raftlin Hid1 PF12722.7 ETO28806.1 - 6.4 4.8 26.0 8.5 4.4 26.0 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SET PF00856.28 ETO28807.1 - 3e-11 44.0 8.0 7.2e-11 42.8 1.1 3.0 2 1 0 2 2 2 1 SET domain AWS PF17907.1 ETO28807.1 - 4.9e-07 29.7 18.9 4.9e-07 29.7 18.9 2.8 3 0 0 3 3 3 1 AWS domain SID-1_RNA_chan PF13965.6 ETO28807.1 - 0.016 13.7 0.5 0.023 13.1 0.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 CDC45 PF02724.14 ETO28807.1 - 0.78 8.0 8.2 0.74 8.0 8.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Herpes_LMP1 PF05297.11 ETO28807.1 - 1.9 7.6 7.2 2.5 7.2 7.2 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) DUF5523 PF17661.1 ETO28807.1 - 2.3 7.8 10.6 0.93 9.1 8.1 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5523) Presenilin PF01080.17 ETO28807.1 - 4 6.1 7.2 5.7 5.6 7.2 1.2 1 0 0 1 1 1 0 Presenilin Sigma70_ner PF04546.13 ETO28807.1 - 5.4 6.8 9.8 3.5 7.5 8.0 1.5 2 0 0 2 2 2 0 Sigma-70, non-essential region Sporozoite_P67 PF05642.11 ETO28807.1 - 6.2 4.8 10.8 9 4.2 10.8 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF2722 PF10846.8 ETO28807.1 - 6.4 5.6 16.7 9.2 5.1 16.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) Nop14 PF04147.12 ETO28807.1 - 7.6 4.6 18.5 9.1 4.3 18.5 1.1 1 0 0 1 1 1 0 Nop14-like family Sep15_SelM PF08806.11 ETO28809.1 - 0.0046 17.1 1.6 0.053 13.7 0.1 2.9 3 0 0 3 3 3 1 Sep15/SelM redox domain PAN_4 PF14295.6 ETO28809.1 - 0.033 14.1 2.0 0.065 13.2 1.0 2.0 2 0 0 2 2 2 0 PAN domain Methyltransf_25 PF13649.6 ETO28810.1 - 3.5e-05 24.4 0.0 0.00066 20.3 0.0 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO28810.1 - 0.00012 22.6 0.1 0.00032 21.3 0.1 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO28810.1 - 0.00062 20.5 0.1 0.0017 19.0 0.1 1.7 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO28810.1 - 0.0085 15.5 0.0 0.017 14.4 0.0 1.5 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family WD40 PF00400.32 ETO28813.1 - 1.1e-70 231.8 31.4 1e-07 32.5 0.0 15.7 16 0 0 16 16 16 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28813.1 - 6.7e-26 90.4 9.1 0.5 10.7 0.0 13.0 2 2 9 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide PF00805.22 ETO28813.1 - 4.7e-07 29.3 6.0 1.3e-06 27.9 6.0 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO28813.1 - 4.3e-05 23.3 14.3 2.7 8.1 0.0 9.3 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO28813.1 - 5.1e-05 23.4 0.4 0.00013 22.1 0.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO28813.1 - 0.00041 20.4 0.2 7 6.8 0.0 5.1 4 1 1 5 5 5 1 Family of unknown function (DUF5570) Str_synth PF03088.16 ETO28813.1 - 0.0019 18.3 0.5 56 4.0 0.0 6.0 6 1 1 7 7 7 0 Strictosidine synthase Pentapeptide_3 PF13576.6 ETO28813.1 - 0.01 16.0 0.4 0.026 14.6 0.4 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) NACHT PF05729.12 ETO28813.1 - 0.011 15.6 0.0 0.039 13.9 0.0 1.9 1 1 0 1 1 1 0 NACHT domain HELP PF03451.14 ETO28814.1 - 0.0017 18.2 0.1 0.0046 16.8 0.1 1.7 1 0 0 1 1 1 1 HELP motif RGS PF00615.19 ETO28815.1 - 0.00076 19.7 4.0 0.0009 19.5 1.9 2.3 2 1 0 2 2 2 1 Regulator of G protein signaling domain SAS-6_N PF16531.5 ETO28815.1 - 0.12 13.0 3.0 0.36 11.5 3.0 1.8 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal PapC_N PF13954.6 ETO28816.1 - 0.034 14.1 0.1 0.083 12.9 0.1 1.5 1 1 0 1 1 1 0 PapC N-terminal domain RPEL PF02755.15 ETO28817.1 - 0.0016 18.1 11.1 0.0058 16.3 0.1 4.9 5 0 0 5 5 5 1 RPEL repeat Sporozoite_P67 PF05642.11 ETO28817.1 - 1.2 7.1 13.9 2.3 6.2 13.9 1.5 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TFIIA PF03153.13 ETO28817.1 - 1.2 9.0 28.6 0.039 14.0 21.5 1.9 1 1 1 2 2 2 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 ETO28818.1 - 4.6e-101 327.9 44.3 3e-09 37.4 0.2 14.0 14 0 0 14 14 14 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28818.1 - 3.2e-42 142.7 4.8 0.00044 20.5 0.0 12.7 1 1 11 13 13 13 10 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO28818.1 - 4.4e-23 82.2 0.1 0.00016 21.6 0.0 6.4 1 1 4 6 6 6 5 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO28818.1 - 1.9e-20 73.1 2.6 0.0067 15.4 0.1 10.3 2 2 7 9 9 9 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO28818.1 - 4.2e-17 62.4 5.9 0.0018 17.7 0.0 6.2 5 2 2 7 7 7 4 WD40-like domain Nup160 PF11715.8 ETO28818.1 - 3.8e-13 48.9 11.9 0.29 9.7 0.1 10.4 5 4 5 10 10 10 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO28818.1 - 1.2e-09 37.2 1.3 0.0032 16.1 0.0 4.4 3 2 1 4 4 4 3 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO28818.1 - 1.5e-06 27.8 5.2 1.3e-05 24.8 2.8 2.3 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO28818.1 - 1.8e-05 24.5 8.6 6.8 6.8 0.0 8.4 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO28818.1 - 2e-05 23.6 17.3 0.055 12.2 0.2 5.9 1 1 2 4 4 4 3 Nup133 N terminal like Nbas_N PF15492.6 ETO28818.1 - 4.6e-05 22.9 2.4 3.2 7.0 0.0 6.5 2 2 5 8 8 8 1 Neuroblastoma-amplified sequence, N terminal Pentapeptide_4 PF13599.6 ETO28818.1 - 0.0001 22.4 1.4 0.00022 21.3 0.1 2.3 2 0 0 2 2 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO28818.1 - 0.0049 17.0 1.2 0.016 15.3 0.1 2.3 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) DUF1366 PF07104.11 ETO28818.1 - 0.93 9.2 2.7 0.73 9.6 0.7 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1366) DUF5570 PF17731.1 ETO28818.1 - 1.1 9.4 10.4 17 5.5 0.6 6.1 4 3 4 8 8 8 0 Family of unknown function (DUF5570) NACHT PF05729.12 ETO28819.1 - 4.1e-11 43.1 0.0 1.2e-10 41.5 0.0 1.9 2 0 0 2 2 2 1 NACHT domain AAA_18 PF13238.6 ETO28819.1 - 6.7e-05 23.5 1.5 0.025 15.1 0.0 3.7 3 0 0 3 3 3 1 AAA domain RelA_SpoT PF04607.17 ETO28819.1 - 0.0041 17.4 0.2 0.015 15.5 0.2 2.0 1 0 0 1 1 1 1 Region found in RelA / SpoT proteins AAA_22 PF13401.6 ETO28819.1 - 0.0062 16.8 0.4 0.046 14.0 0.1 2.7 2 1 0 2 2 2 1 AAA domain TsaE PF02367.17 ETO28819.1 - 0.022 14.8 0.0 0.25 11.4 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA PF00004.29 ETO28819.1 - 0.037 14.5 0.1 0.33 11.4 0.0 2.6 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO28819.1 - 0.044 14.2 0.1 0.48 10.8 0.0 2.7 1 1 1 2 2 2 0 AAA ATPase domain RNA_helicase PF00910.22 ETO28819.1 - 0.059 13.8 0.1 0.24 11.8 0.1 2.2 1 1 0 1 1 1 0 RNA helicase AAA_5 PF07728.14 ETO28819.1 - 0.092 12.8 0.1 1.1 9.3 0.0 2.4 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_33 PF13671.6 ETO28819.1 - 0.13 12.4 0.0 0.59 10.3 0.0 2.1 1 1 0 1 1 1 0 AAA domain CUE PF02845.16 ETO28819.1 - 0.61 9.9 3.3 0.46 10.2 0.1 2.6 4 0 0 4 4 4 0 CUE domain PA26 PF04636.13 ETO28820.1 - 1.4e-28 100.1 0.0 1.4e-28 100.1 0.0 2.1 2 1 1 3 3 3 1 PA26 p53-induced protein (sestrin) PA26 PF04636.13 ETO28821.1 - 6.8e-13 48.3 0.5 8.9e-13 47.9 0.5 1.2 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) RQC PF09382.10 ETO28823.1 - 8.7e-05 22.3 0.0 0.00026 20.8 0.0 1.8 1 0 0 1 1 1 1 RQC domain CPSF100_C PF13299.6 ETO28823.1 - 5.5 7.1 13.7 3.1 7.9 0.8 2.5 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal PGM_PMM_I PF02878.16 ETO28824.1 - 2.1e-14 53.4 0.1 1.9e-07 30.8 0.1 3.6 2 1 1 3 3 3 2 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_III PF02880.16 ETO28824.1 - 9.5e-05 22.6 0.0 0.00022 21.4 0.0 1.6 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III PGM_PMM_II PF02879.16 ETO28824.1 - 0.023 15.3 0.0 0.076 13.6 0.0 1.9 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Bac_export_2 PF01312.19 ETO28824.1 - 0.15 11.3 0.0 0.15 11.3 0.0 1.8 2 0 0 2 2 2 0 FlhB HrpN YscU SpaS Family Glyco_trans_2_3 PF13632.6 ETO28824.1 - 7.7 6.4 9.2 18 5.2 9.2 1.6 1 0 0 1 1 1 0 Glycosyl transferase family group 2 Surfac_D-trimer PF09006.11 ETO28825.1 - 0.018 14.9 0.0 0.39 10.6 0.0 2.7 3 0 0 3 3 3 0 Lung surfactant protein D coiled-coil trimerisation DUF4394 PF14339.6 ETO28825.1 - 0.039 13.3 0.1 0.068 12.5 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4394) Tox-REase-2 PF15646.6 ETO28825.1 - 0.095 12.9 0.6 0.25 11.5 0.0 1.9 2 0 0 2 2 2 0 Restriction endonuclease fold toxin 2 Sox_N PF12444.8 ETO28825.1 - 0.26 12.5 2.2 15 6.8 0.0 2.6 2 0 0 2 2 2 0 Sox developmental protein N terminal SAM_3 PF18016.1 ETO28826.1 - 0.084 12.7 0.1 5.4 6.9 0.0 2.4 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) Ank_4 PF13637.6 ETO28828.1 - 3.5e-20 72.1 0.0 1.4e-11 44.7 0.0 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO28828.1 - 5.5e-17 62.1 0.0 2e-16 60.3 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO28828.1 - 5.9e-17 60.0 0.3 6.1e-05 23.1 0.0 4.1 4 0 0 4 4 4 3 Ankyrin repeat Ank_5 PF13857.6 ETO28828.1 - 9.2e-15 54.5 0.2 6.5e-06 26.3 0.0 4.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO28828.1 - 4.8e-13 48.9 0.0 0.00013 22.3 0.0 3.5 3 0 0 3 3 3 3 Ankyrin repeat Arginase PF00491.21 ETO28832.1 - 4.5e-30 105.1 0.0 5.2e-27 95.1 0.0 2.2 2 0 0 2 2 2 2 Arginase family LMF1 PF06762.14 ETO28835.1 - 7.9e-23 81.3 7.3 5.5e-16 58.7 0.2 3.0 1 1 2 3 3 3 2 Lipase maturation factor TBCA PF02970.16 ETO28836.1 - 0.013 15.8 0.2 0.023 15.0 0.2 1.4 1 0 0 1 1 1 0 Tubulin binding cofactor A RhoGAP PF00620.27 ETO28837.1 - 1.2e-22 80.4 0.0 2.2e-22 79.5 0.0 1.4 1 0 0 1 1 1 1 RhoGAP domain Exo_endo_phos PF03372.23 ETO28837.1 - 0.00082 18.9 0.0 0.024 14.2 0.0 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family VHP PF02209.19 ETO28837.1 - 0.15 12.2 1.5 0.49 10.5 1.5 2.0 1 0 0 1 1 1 0 Villin headpiece domain Intimin_C PF07979.11 ETO28837.1 - 0.38 11.2 2.1 15 6.0 0.4 2.5 2 0 0 2 2 2 0 Intimin C-type lectin domain PH PF00169.29 ETO28838.1 - 5.6e-07 30.0 0.1 5.6e-07 30.0 0.1 2.6 3 0 0 3 3 3 1 PH domain PH_8 PF15409.6 ETO28838.1 - 0.0015 18.8 0.2 0.006 16.8 0.1 2.1 2 0 0 2 2 2 1 Pleckstrin homology domain DUF4085 PF13315.6 ETO28838.1 - 0.26 10.9 8.8 0.61 9.7 8.8 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4085) XAP5 PF04921.14 ETO28838.1 - 0.72 9.6 17.5 1.3 8.8 17.5 1.4 1 0 0 1 1 1 0 XAP5, circadian clock regulator CDC45 PF02724.14 ETO28838.1 - 2.9 6.1 24.2 4.7 5.4 24.2 1.3 1 0 0 1 1 1 0 CDC45-like protein RasGAP PF00616.19 ETO28838.1 - 3.2 7.4 15.3 0.27 10.9 9.1 2.3 3 0 0 3 3 3 0 GTPase-activator protein for Ras-like GTPase Histone PF00125.24 ETO28838.1 - 6.2 7.2 15.0 16 5.9 14.7 1.9 1 1 0 1 1 1 0 Core histone H2A/H2B/H3/H4 RNA_pol_Rpc4 PF05132.14 ETO28838.1 - 8.7 6.8 9.5 17 5.8 9.5 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 tRNA-synt_1 PF00133.22 ETO28839.1 - 7.8e-173 576.0 6.2 2.8e-172 574.1 0.0 3.0 2 1 0 2 2 1 1 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ETO28839.1 - 7.8e-32 110.3 0.1 7.8e-32 110.3 0.1 2.3 2 0 0 2 2 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ETO28839.1 - 1.1e-11 44.2 2.0 1.4e-06 27.4 0.0 4.3 5 0 0 5 5 5 3 tRNA synthetases class I (M) tRNA-synt_1_2 PF13603.6 ETO28839.1 - 8.7e-11 41.7 0.0 8.7e-11 41.7 0.0 2.9 2 2 1 3 3 2 1 Leucyl-tRNA synthetase, Domain 2 Zip PF02535.22 ETO28839.1 - 0.086 12.0 3.6 0.13 11.4 3.6 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Rtf2 PF04641.12 ETO28839.1 - 0.18 11.1 20.6 0.3 10.4 20.6 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger FAM176 PF14851.6 ETO28839.1 - 0.26 10.9 9.7 0.5 10.0 9.1 1.8 1 1 0 1 1 1 0 FAM176 family O-antigen_lig PF13425.6 ETO28839.1 - 0.46 9.2 7.2 0.7 8.6 7.2 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein PPL5 PF18168.1 ETO28839.1 - 0.75 9.0 6.7 1.4 8.1 6.7 1.5 1 0 0 1 1 1 0 Prim-pol family 5 Ureide_permease PF07168.11 ETO28839.1 - 1.1 8.0 3.4 1.9 7.2 3.4 1.3 1 0 0 1 1 1 0 Ureide permease EMC3_TMCO1 PF01956.16 ETO28839.1 - 1.8 8.2 11.1 4 7.1 11.1 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like EOS1 PF12326.8 ETO28839.1 - 8.3 6.3 6.8 28 4.6 4.1 2.4 2 0 0 2 2 2 0 N-glycosylation protein LigT_PEase PF02834.16 ETO28840.1 - 2.2e-08 34.2 0.2 2.5e-05 24.4 0.0 2.5 2 1 0 2 2 2 2 LigT like Phosphoesterase DUF2052 PF09747.9 ETO28841.1 - 0.019 15.1 2.9 0.019 15.1 2.9 2.1 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF5523 PF17661.1 ETO28841.1 - 1.1 8.9 11.6 1.2 8.7 5.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) CLN3 PF02487.17 ETO28841.1 - 3.9 6.4 6.8 0.4 9.7 1.0 1.9 2 0 0 2 2 2 0 CLN3 protein CSG2 PF16965.5 ETO28841.1 - 5.4 5.9 7.2 0.97 8.3 0.5 2.1 2 0 0 2 2 2 0 Ceramide synthase regulator CPSF100_C PF13299.6 ETO28841.1 - 6 7.0 11.4 11 6.2 1.0 2.1 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Med21 PF11221.8 ETO28842.1 - 0.0049 17.1 0.4 0.07 13.4 0.5 2.0 2 0 0 2 2 2 1 Subunit 21 of Mediator complex CedA PF10729.9 ETO28842.1 - 0.083 12.7 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 Cell division activator CedA Glyco_hydro_4C PF11975.8 ETO28843.1 - 0.054 13.6 0.2 0.066 13.3 0.2 1.2 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain P_C10 PF14974.6 ETO28843.1 - 0.075 13.1 0.5 0.17 12.0 0.2 1.8 1 1 1 2 2 2 0 Protein C10 HTH_9 PF08221.11 ETO28843.1 - 0.1 12.7 0.2 7.1 6.8 0.1 2.6 2 0 0 2 2 2 0 RNA polymerase III subunit RPC82 helix-turn-helix domain IBN_N PF03810.19 ETO28844.1 - 0.01 15.8 1.6 0.024 14.6 0.5 2.1 2 0 0 2 2 2 0 Importin-beta N-terminal domain CPW_WPC PF09717.10 ETO28844.1 - 0.15 13.1 1.8 0.35 11.9 0.5 2.2 2 1 0 2 2 2 0 Plasmodium falciparum domain of unknown function (CPW_WPC) SinI PF08671.10 ETO28848.1 - 0.17 11.7 0.1 13 5.7 0.0 2.6 2 0 0 2 2 2 0 Anti-repressor SinI Cep57_CLD_2 PF14197.6 ETO28849.1 - 0.018 15.1 7.3 0.018 15.1 7.3 5.2 3 2 1 4 4 4 0 Centrosome localisation domain of PPC89 NOA36 PF06524.12 ETO28849.1 - 2.2 7.5 26.5 0.029 13.7 19.2 1.6 2 0 0 2 2 2 0 NOA36 protein YabA PF06156.13 ETO28849.1 - 3.5 8.3 30.4 0.93 10.2 4.8 4.1 2 1 2 4 4 4 0 Initiation control protein YabA Ndc1_Nup PF09531.10 ETO28850.1 - 1.4 7.5 10.2 1.6 7.3 10.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup WD40 PF00400.32 ETO28851.1 - 9.8e-44 146.5 18.5 5.4e-09 36.5 0.1 6.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28851.1 - 2e-14 53.6 0.9 0.014 15.6 0.0 5.6 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28851.1 - 1.8e-12 46.9 0.4 0.0046 16.0 0.0 5.2 2 1 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO28851.1 - 1.9e-06 26.9 2.7 1.4 7.5 0.0 4.4 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO28851.1 - 5.5e-05 22.6 0.8 0.0026 17.1 0.2 2.8 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO28851.1 - 0.00024 21.0 3.9 3.8 7.6 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO28851.1 - 0.00035 19.4 5.3 0.16 10.7 0.2 4.3 2 1 3 5 5 5 3 Nup133 N terminal like eIF2A PF08662.11 ETO28851.1 - 0.0012 18.7 0.0 0.24 11.3 0.0 2.8 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ETO28851.1 - 0.0071 15.4 0.0 0.17 10.9 0.0 2.4 1 1 0 2 2 2 1 Coatomer WD associated region NTNH_C PF08470.10 ETO28851.1 - 0.016 15.1 0.0 0.038 13.9 0.0 1.6 2 0 0 2 2 2 0 Nontoxic nonhaemagglutinin C-terminal DUF4999 PF16390.5 ETO28851.1 - 0.072 13.3 1.8 60 4.0 0.0 4.4 4 1 0 4 4 4 0 Domain of unknown function DUF5570 PF17731.1 ETO28851.1 - 0.13 12.4 2.4 0.49 10.5 0.4 2.8 3 1 1 4 4 4 0 Family of unknown function (DUF5570) CLPTM1 PF05602.12 ETO28854.1 - 0.83 8.6 6.7 0.93 8.4 6.7 1.1 1 0 0 1 1 1 0 Cleft lip and palate transmembrane protein 1 (CLPTM1) dsRBD2 PF17842.1 ETO28854.1 - 2.1 8.5 9.3 3 8.1 9.3 1.4 1 1 0 1 1 1 0 Double-stranded RNA binding domain 2 C_Hendra PF16821.5 ETO28854.1 - 2.5 8.0 10.6 3 7.7 10.6 1.1 1 0 0 1 1 1 0 C protein from hendra and measles viruses RGS12_usC PF16612.5 ETO28856.1 - 0.13 12.7 0.3 0.13 12.7 0.3 1.5 2 0 0 2 2 2 0 C-terminal unstructured region of RGS12 Lipase_GDSL_2 PF13472.6 ETO28862.1 - 6.9e-12 46.1 0.0 9.3e-12 45.7 0.0 1.2 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ETO28862.1 - 2.4e-07 30.9 0.0 6e-07 29.6 0.0 1.7 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase SKG6 PF08693.10 ETO28864.1 - 0.075 12.5 0.8 0.17 11.3 0.8 1.6 1 0 0 1 1 1 0 Transmembrane alpha-helix domain HemY_N PF07219.13 ETO28864.1 - 0.19 12.0 0.8 0.39 10.9 0.8 1.5 1 0 0 1 1 1 0 HemY protein N-terminus CD34_antigen PF06365.12 ETO28864.1 - 0.28 10.8 3.3 2.7 7.5 0.6 2.2 1 1 1 2 2 2 0 CD34/Podocalyxin family CcmD PF04995.14 ETO28864.1 - 1.1 9.4 3.5 4.9 7.3 3.5 1.9 1 1 0 1 1 1 0 Heme exporter protein D (CcmD) Roughex PF06020.11 ETO28865.1 - 0.1 11.7 3.9 0.12 11.4 3.9 1.1 1 0 0 1 1 1 0 Drosophila roughex protein ANAPC4_WD40 PF12894.7 ETO28866.1 - 5.7e-07 29.7 0.2 0.00027 21.2 0.3 3.3 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Vps16_N PF04841.13 ETO28866.1 - 0.0016 17.3 0.1 0.025 13.3 0.1 2.1 2 0 0 2 2 2 1 Vps16, N-terminal region WD40 PF00400.32 ETO28866.1 - 0.004 18.0 0.4 7.8 7.6 0.0 4.4 5 1 0 5 5 5 1 WD domain, G-beta repeat DUF2415 PF10313.9 ETO28866.1 - 0.022 14.7 0.1 0.11 12.5 0.0 2.2 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) GAF PF01590.26 ETO28868.1 - 2.3e-07 31.5 0.0 5e-07 30.4 0.0 1.6 1 0 0 1 1 1 1 GAF domain Yop-YscD_cpl PF16697.5 ETO28868.1 - 4.7e-06 26.8 0.0 1.3e-05 25.5 0.0 1.7 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain FHA PF00498.26 ETO28868.1 - 0.00039 20.7 0.2 0.0017 18.7 0.0 2.2 2 0 0 2 2 2 1 FHA domain Phage_holin_T PF11031.8 ETO28868.1 - 0.65 9.4 5.2 1.4 8.3 5.2 1.5 1 0 0 1 1 1 0 Bacteriophage T holin DUF4044 PF13253.6 ETO28868.1 - 5.8 6.5 5.4 13 5.4 5.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4044) Chisel PF15355.6 ETO28869.1 - 0.022 15.0 0.5 0.23 11.7 0.0 2.7 3 0 0 3 3 3 0 Stretch-responsive small skeletal muscle X protein, Chisel DUF2615 PF11027.8 ETO28870.1 - 0.00073 19.6 0.8 0.00073 19.6 0.8 2.5 2 1 1 3 3 3 1 Protein of unknown function (DUF2615) CAF1A PF12253.8 ETO28870.1 - 0.0045 17.1 2.1 0.0045 17.1 2.1 2.4 2 1 0 2 2 2 1 Chromatin assembly factor 1 subunit A DUF1676 PF07898.13 ETO28870.1 - 0.006 16.6 0.4 0.006 16.6 0.4 2.0 3 0 0 3 3 3 1 Protein of unknown function (DUF1676) SARAF PF06682.12 ETO28870.1 - 0.02 14.5 0.9 0.036 13.7 0.9 1.4 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis ETRAMP PF09716.10 ETO28870.1 - 0.66 10.1 0.0 0.66 10.1 0.0 3.4 3 1 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO28871.1 - 2.6e-67 221.1 16.5 1.7e-10 41.3 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28871.1 - 9.1e-28 96.4 2.8 1.2e-06 28.7 0.1 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28871.1 - 6.7e-18 64.7 0.4 0.24 10.3 0.0 6.9 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO28871.1 - 1.7e-12 47.6 0.2 6e-06 26.3 0.0 3.5 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO28871.1 - 2.9e-09 36.1 2.7 0.18 10.4 0.1 5.6 2 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO28871.1 - 5.8e-08 32.4 1.6 0.15 11.4 0.1 3.8 2 1 2 4 4 4 4 WD40-like domain PD40 PF07676.12 ETO28871.1 - 4.1e-07 29.8 1.9 0.52 10.3 0.0 5.0 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO28871.1 - 3.6e-06 26.0 6.2 0.068 11.9 0.1 3.9 1 1 3 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO28871.1 - 6.8e-06 24.9 0.4 0.0062 15.1 0.0 2.8 1 1 3 4 4 4 3 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO28871.1 - 7e-05 22.5 0.6 0.0075 15.9 0.0 2.7 2 1 1 3 3 3 1 PQQ-like domain Proteasome_A_N PF10584.9 ETO28871.1 - 0.0071 16.0 4.7 24 4.7 0.0 5.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature HARP PF07443.13 ETO28871.1 - 0.01 15.5 0.0 0.14 11.8 0.0 2.8 3 0 0 3 3 3 1 HepA-related protein (HARP) Arena_nucleocap PF00843.17 ETO28871.1 - 0.041 12.8 0.4 1.9 7.3 0.0 2.6 2 2 0 2 2 2 0 Arenavirus nucleocapsid N-terminal domain VID27 PF08553.10 ETO28871.1 - 0.096 11.7 0.1 5.6 5.9 0.0 2.7 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain DUF5122 PF17164.4 ETO28871.1 - 0.12 12.7 2.5 20 5.6 0.0 3.7 4 0 0 4 4 3 0 Domain of unknown function (DUF5122) beta-propeller Colicin_Ia PF11504.8 ETO28871.1 - 0.16 12.1 0.2 48 4.2 0.0 3.8 4 0 0 4 4 4 0 Colicin Ia PH_8 PF15409.6 ETO28871.1 - 3.5 8.0 9.0 26 5.2 3.0 4.1 4 2 1 5 5 5 0 Pleckstrin homology domain SUKH-3 PF14433.6 ETO28872.1 - 0.0094 16.4 0.1 0.011 16.2 0.1 1.1 1 0 0 1 1 1 1 SUKH-3 immunity protein SDA1 PF05285.12 ETO28873.1 - 0.069 12.6 0.0 0.069 12.6 0.0 3.6 1 1 2 3 3 3 0 SDA1 DUF5301 PF17225.3 ETO28874.1 - 0.066 13.7 0.6 0.066 13.7 0.6 1.9 1 1 0 2 2 2 0 Domain of unknown function (DUF5300) DUF1336 PF07059.12 ETO28875.1 - 2e-51 175.2 0.0 3.3e-51 174.6 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) HSP70 PF00012.20 ETO28876.1 - 1.8e-92 310.5 10.1 8.9e-51 172.8 0.0 4.5 4 1 0 4 4 4 4 Hsp70 protein MreB_Mbl PF06723.13 ETO28876.1 - 2.7e-07 29.7 0.4 2.7e-06 26.5 0.0 2.4 3 0 0 3 3 3 1 MreB/Mbl protein DUF842 PF05811.13 ETO28876.1 - 0.03 14.0 0.3 0.03 14.0 0.3 2.5 3 0 0 3 3 3 0 Eukaryotic protein of unknown function (DUF842) DUF903 PF06004.12 ETO28876.1 - 0.12 12.2 0.3 0.36 10.8 0.3 1.8 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF903) Hydin_ADK PF17213.3 ETO28876.1 - 0.35 11.1 4.8 0.63 10.3 3.3 2.1 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain Cullin PF00888.22 ETO28877.1 - 9.2e-132 440.7 23.3 1.7e-128 429.9 23.3 2.9 1 1 0 1 1 1 1 Cullin family SecA_SW PF07516.13 ETO28877.1 - 0.017 15.2 0.2 0.017 15.2 0.2 3.2 3 0 0 3 3 3 0 SecA Wing and Scaffold domain HrcA PF01628.21 ETO28877.1 - 0.017 15.0 1.7 2.4 8.0 0.4 2.6 2 0 0 2 2 2 0 HrcA protein C terminal domain PRD PF00874.20 ETO28877.1 - 0.44 10.9 6.7 1.5 9.2 0.4 3.7 3 1 0 3 3 3 0 PRD domain WD40 PF00400.32 ETO28879.1 - 9.6e-22 76.9 10.4 4.4e-06 27.3 0.7 4.8 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28879.1 - 9.4e-08 32.3 1.6 0.046 14.0 0.1 3.8 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO28879.1 - 3.4e-06 26.0 0.2 7.4e-05 21.6 0.0 2.3 1 1 1 2 2 2 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO28879.1 - 0.0022 17.4 0.7 0.016 14.6 0.2 1.9 1 1 1 2 2 2 1 WD40-like domain DUF5046 PF16465.5 ETO28879.1 - 0.02 14.4 0.0 0.036 13.5 0.0 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF5046) Nucleoporin_N PF08801.11 ETO28879.1 - 0.022 13.5 1.3 0.15 10.7 0.1 2.5 1 1 2 3 3 3 0 Nup133 N terminal like Ion_trans PF00520.31 ETO28880.1 - 1.8e-26 92.9 61.3 6.7e-20 71.4 24.7 3.2 3 0 0 3 3 3 3 Ion transport protein EF-hand_6 PF13405.6 ETO28880.1 - 0.0001 22.0 1.1 0.12 12.3 0.2 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO28880.1 - 0.0013 18.1 3.6 0.16 11.6 1.4 2.7 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO28880.1 - 0.0028 18.1 1.9 2.6 8.6 0.5 2.6 2 0 0 2 2 2 2 EF-hand domain pair TerB PF05099.13 ETO28880.1 - 0.16 11.9 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 Tellurite resistance protein TerB Trypan_PARP PF05887.11 ETO28881.1 - 4.8 7.2 7.6 0.19 11.7 1.3 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF5620 PF18522.1 ETO28881.1 - 7.6 7.0 11.0 4.1 7.8 0.3 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF5620) CPSF100_C PF13299.6 ETO28882.1 - 3.6 7.7 9.4 2.3 8.4 1.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CHAT PF12770.7 ETO28883.1 - 4.9e-06 26.2 0.0 9e-06 25.3 0.0 1.4 1 0 0 1 1 1 1 CHAT domain Raptor_N PF14538.6 ETO28883.1 - 0.0052 16.7 0.0 0.014 15.3 0.0 1.7 1 0 0 1 1 1 1 Raptor N-terminal CASPase like domain HOIP-UBA PF16678.5 ETO28883.1 - 0.015 15.3 0.0 0.039 13.9 0.0 1.6 1 0 0 1 1 1 0 HOIP UBA domain pair AAA_16 PF13191.6 ETO28883.1 - 0.12 12.8 0.0 0.45 10.9 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain F420_oxidored PF03807.17 ETO28884.1 - 3.5e-15 56.4 0.0 4.9e-15 55.9 0.0 1.2 1 0 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent PDH PF02153.17 ETO28884.1 - 5.4e-08 32.2 0.4 6.9e-08 31.8 0.4 1.1 1 0 0 1 1 1 1 Prephenate dehydrogenase NAD_Gly3P_dh_N PF01210.23 ETO28884.1 - 1.1e-05 25.4 6.2 0.0004 20.4 6.2 2.1 1 1 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus NAD_binding_2 PF03446.15 ETO28884.1 - 8.5e-05 22.8 0.0 0.00012 22.3 0.0 1.3 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase ApbA PF02558.16 ETO28884.1 - 0.0011 18.7 3.4 0.0073 16.0 3.4 1.9 1 1 0 1 1 1 1 Ketopantoate reductase PanE/ApbA IlvN PF07991.12 ETO28884.1 - 0.035 13.7 0.0 0.046 13.3 0.0 1.1 1 0 0 1 1 1 0 Acetohydroxy acid isomeroreductase, NADPH-binding domain UDPG_MGDP_dh_C PF03720.15 ETO28884.1 - 0.058 13.8 0.0 0.088 13.2 0.0 1.3 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain ThiF PF00899.21 ETO28884.1 - 0.55 9.6 2.4 5.6 6.3 0.6 2.1 1 1 0 2 2 2 0 ThiF family Tudor-knot PF11717.8 ETO28886.1 - 1.2e-06 28.3 8.2 7.8e-06 25.7 8.2 2.0 1 1 0 1 1 1 1 RNA binding activity-knot of a chromodomain DUF1203 PF06718.11 ETO28888.1 - 0.0016 18.7 0.6 0.0037 17.5 0.3 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1203) Nucleoporin_FG2 PF15967.5 ETO28888.1 - 0.0043 15.7 0.6 0.0076 14.8 0.6 1.3 1 0 0 1 1 1 1 Nucleoporin FG repeated region eRF1_3 PF03465.15 ETO28888.1 - 0.0082 16.6 1.2 0.36 11.3 0.8 2.4 2 0 0 2 2 2 1 eRF1 domain 3 DUF2183 PF09949.9 ETO28888.1 - 0.17 12.3 3.0 1.8 9.0 0.8 3.0 2 2 0 2 2 2 0 Uncharacterized conserved protein (DUF2183) LAGLIDADG_1 PF00961.19 ETO28888.1 - 0.3 12.1 3.7 0.87 10.6 3.7 1.9 1 0 0 1 1 1 0 LAGLIDADG endonuclease NPV_P10 PF05531.12 ETO28888.1 - 0.53 10.8 3.5 16 6.1 0.4 3.3 2 1 1 3 3 3 0 Nucleopolyhedrovirus P10 protein CorA PF01544.18 ETO28888.1 - 2.9 7.1 6.9 0.7 9.1 0.8 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF4335 PF14233.6 ETO28888.1 - 6.6 6.6 8.1 9.2 6.1 5.0 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4335) CCDC-167 PF15188.6 ETO28888.1 - 8.3 6.8 10.9 1.6 9.1 0.2 3.8 2 2 1 3 3 3 0 Coiled-coil domain-containing protein 167 TPR_12 PF13424.6 ETO28889.1 - 0.007 16.6 0.5 0.012 15.8 0.5 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28889.1 - 0.17 12.1 1.7 0.23 11.7 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3829 PF12889.7 ETO28890.1 - 0.0006 19.4 0.3 0.00084 18.9 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3829) LAGLIDADG_1 PF00961.19 ETO28890.1 - 0.0094 16.9 2.3 0.0094 16.9 2.3 1.7 1 1 0 1 1 1 1 LAGLIDADG endonuclease Fip1 PF05182.13 ETO28892.1 - 3.1e-20 71.4 3.9 5.2e-20 70.7 3.9 1.4 1 0 0 1 1 1 1 Fip1 motif Claudin_2 PF13903.6 ETO28894.1 - 0.013 15.2 0.0 0.018 14.8 0.0 1.1 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Shisa PF13908.6 ETO28894.1 - 0.018 15.3 0.1 0.023 14.9 0.1 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator TMEM154 PF15102.6 ETO28894.1 - 0.033 14.1 0.0 0.05 13.5 0.0 1.3 1 0 0 1 1 1 0 TMEM154 protein family Prominin PF05478.11 ETO28894.1 - 0.096 10.6 0.0 0.14 10.0 0.0 1.2 1 0 0 1 1 1 0 Prominin IFT43 PF15305.6 ETO28895.1 - 6.1e-05 23.2 0.1 6.2e-05 23.2 0.1 1.2 1 0 0 1 1 1 1 Intraflagellar transport protein 43 DUF4378 PF14309.6 ETO28896.1 - 0.11 12.8 1.6 0.13 12.6 1.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4378) SUB1_ProdP9 PF18213.1 ETO28897.1 - 0.11 12.4 0.9 0.57 10.1 0.9 2.3 1 0 0 1 1 1 0 SUB1 protease Prodomain ProdP9 Baculo_PEP_C PF04513.12 ETO28897.1 - 3.7 7.6 12.3 0.11 12.6 1.8 3.4 2 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pre-PUA PF17832.1 ETO28898.1 - 0.16 12.7 3.8 0.82 10.4 0.1 3.1 3 0 0 3 3 3 0 Pre-PUA-like domain E1_4HB PF16191.5 ETO28899.1 - 0.071 13.3 0.2 0.76 10.0 0.2 2.4 1 1 0 1 1 1 0 Ubiquitin-activating enzyme E1 four-helix bundle NLE PF08154.12 ETO28899.1 - 0.08 13.5 0.2 0.4 11.2 0.1 2.0 2 0 0 2 2 2 0 NLE (NUC135) domain SUI1 PF01253.22 ETO28900.1 - 2e-13 50.6 1.5 2.8e-13 50.2 0.3 1.9 2 1 0 2 2 2 1 Translation initiation factor SUI1 AntA PF08346.12 ETO28900.1 - 0.018 15.6 0.3 0.065 13.8 0.1 1.9 2 0 0 2 2 2 0 AntA/AntB antirepressor SWIB PF02201.18 ETO28900.1 - 0.023 14.6 0.5 0.054 13.4 0.1 1.8 1 1 1 2 2 2 0 SWIB/MDM2 domain Img2 PF05046.14 ETO28900.1 - 0.043 14.1 0.3 0.14 12.4 0.1 1.9 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) WD40 PF00400.32 ETO28901.1 - 2.7e-59 195.7 21.3 4e-08 33.8 0.6 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28901.1 - 9.2e-25 86.8 0.9 0.0093 16.2 0.0 7.7 2 1 6 8 8 8 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28901.1 - 2.5e-16 59.6 0.4 0.079 11.9 0.0 7.4 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO28901.1 - 4.9e-11 42.0 2.4 0.51 8.9 0.0 6.6 4 2 3 7 7 7 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO28901.1 - 6.7e-08 32.2 0.2 0.013 14.8 0.0 4.2 2 1 1 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO28901.1 - 4e-05 22.3 0.1 0.0073 14.9 0.0 2.8 3 1 0 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO28901.1 - 0.00018 21.0 1.2 3.3 6.9 0.0 4.3 2 1 3 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO28901.1 - 0.00096 19.2 1.4 19 5.4 0.0 4.8 3 2 2 5 5 5 0 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO28901.1 - 0.002 17.0 6.3 1.2 7.8 0.1 4.7 2 2 3 5 5 5 2 Nup133 N terminal like DUF5046 PF16465.5 ETO28901.1 - 0.002 17.6 0.0 0.29 10.5 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5046) DUF4784 PF16023.5 ETO28901.1 - 0.033 13.1 0.0 0.79 8.6 0.0 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF4784) LEM PF03020.15 ETO28903.1 - 0.012 15.2 0.0 0.033 13.8 0.0 1.7 1 0 0 1 1 1 0 LEM domain PTPS PF01242.19 ETO28903.1 - 0.071 13.1 0.2 0.55 10.2 0.0 2.1 2 0 0 2 2 2 0 6-pyruvoyl tetrahydropterin synthase DUF3439 PF11921.8 ETO28903.1 - 0.25 11.3 7.7 0.43 10.6 7.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO28903.1 - 0.41 8.8 11.1 0.55 8.4 11.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO28903.1 - 0.7 9.9 15.6 1.3 9.0 15.6 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein Secretin_N_2 PF07655.13 ETO28903.1 - 6.1 7.5 12.2 3.1 8.4 6.2 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Pre-PUA PF17832.1 ETO28904.1 - 9.1e-07 29.5 1.2 0.00042 20.9 0.1 2.3 2 0 0 2 2 2 2 Pre-PUA-like domain A_deaminase PF00962.22 ETO28906.1 - 9.1e-48 163.3 0.3 1.6e-47 162.5 0.3 1.3 1 0 0 1 1 1 1 Adenosine/AMP deaminase Amidohydro_1 PF01979.20 ETO28906.1 - 0.061 12.6 0.1 0.096 12.0 0.1 1.4 1 0 0 1 1 1 0 Amidohydrolase family Ras PF00071.22 ETO28908.1 - 7e-25 87.5 3.2 2.9e-18 66.0 0.3 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO28908.1 - 1.6e-09 38.0 0.8 0.00039 20.6 0.1 2.5 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO28908.1 - 1.7e-06 28.1 0.2 0.028 14.3 0.0 2.2 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ETO28908.1 - 0.0028 18.1 0.0 0.004 17.6 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO28908.1 - 0.012 15.9 0.1 0.024 14.9 0.1 1.7 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO28908.1 - 0.023 14.7 0.1 0.24 11.4 0.0 2.1 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO28908.1 - 0.088 13.3 0.2 0.19 12.2 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA PF00004.29 ETO28908.1 - 0.088 13.2 0.1 0.86 10.0 0.0 1.8 1 1 1 2 2 2 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETO28908.1 - 0.098 12.6 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 NACHT domain Omptin PF01278.20 ETO28909.1 - 0.0023 17.0 0.7 0.0028 16.8 0.7 1.0 1 0 0 1 1 1 1 Omptin family CENP-X PF09415.10 ETO28909.1 - 0.013 15.8 0.7 0.019 15.3 0.7 1.3 1 0 0 1 1 1 0 CENP-S associating Centromere protein X DUF1689 PF07954.11 ETO28909.1 - 0.031 14.7 1.1 0.037 14.4 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1689) OAD_gamma PF04277.13 ETO28909.1 - 0.28 11.8 1.1 0.56 10.8 1.1 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF3826 PF12875.7 ETO28910.1 - 0.017 15.3 5.0 0.04 14.1 5.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3826) AAA_26 PF13500.6 ETO28910.1 - 0.081 12.7 1.7 0.15 11.9 1.7 1.3 1 0 0 1 1 1 0 AAA domain RPA43_OB PF17875.1 ETO28910.1 - 0.33 11.6 6.5 1.9 9.1 1.1 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Macoilin PF09726.9 ETO28911.1 - 0.22 10.0 28.8 0.28 9.7 28.8 1.1 1 0 0 1 1 1 0 Macoilin family Trypan_PARP PF05887.11 ETO28911.1 - 0.61 10.1 9.8 0.99 9.4 9.8 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) AF-4 PF05110.13 ETO28911.1 - 3.3 5.7 50.1 3.3e+02 -0.9 50.1 2.1 1 1 0 1 1 1 0 AF-4 proto-oncoprotein HECT PF00632.25 ETO28912.1 - 1.2e-57 195.8 0.9 3.2e-57 194.4 0.9 1.7 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) VWA PF00092.28 ETO28914.1 - 7.8e-08 32.8 0.1 1.5e-07 31.9 0.1 1.5 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO28914.1 - 4.2e-05 24.2 0.0 8.7e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO28914.1 - 9.8e-05 22.3 0.3 0.00032 20.7 0.0 1.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Zip PF02535.22 ETO28914.1 - 0.17 11.0 0.5 0.22 10.7 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Peptidase_S49_N PF08496.10 ETO28914.1 - 2.2 8.3 6.2 5.5 7.0 6.2 1.6 1 1 0 1 1 1 0 Peptidase family S49 N-terminal IPK PF03770.16 ETO28916.1 - 3.4e-08 33.6 0.2 3.5e-07 30.3 0.2 2.0 1 1 0 1 1 1 1 Inositol polyphosphate kinase IPK PF03770.16 ETO28917.1 - 0.012 15.4 0.0 0.015 15.1 0.0 1.3 1 0 0 1 1 1 0 Inositol polyphosphate kinase UTP25 PF06862.12 ETO28918.1 - 4.7e-90 302.6 24.4 1.4e-81 274.7 18.6 3.5 2 1 0 2 2 2 2 Utp25, U3 small nucleolar RNA-associated SSU processome protein 25 zf-DBF PF07535.12 ETO28918.1 - 8.4 6.6 7.8 0.55 10.4 0.8 2.8 3 0 0 3 3 3 0 DBF zinc finger DUF1768 PF08719.11 ETO28919.1 - 2.8e-45 154.4 1.1 4.2e-45 153.9 1.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) DiSB-ORF2_chro PF16506.5 ETO28919.1 - 0.14 12.2 0.0 0.36 10.9 0.0 1.7 1 0 0 1 1 1 0 Putative virion glycoprotein of insect viruses FOXO_KIX_bdg PF16675.5 ETO28920.1 - 0.028 14.7 0.4 0.081 13.2 0.4 1.9 1 0 0 1 1 1 0 KIX-binding domain of forkhead box O, CR2 CENP-F_leu_zip PF10473.9 ETO28920.1 - 0.14 12.1 10.4 0.2 11.7 9.8 1.5 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GIT_CC PF16559.5 ETO28920.1 - 3.6 7.5 7.5 8.4 6.4 0.4 2.7 2 1 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor zf-RING_2 PF13639.6 ETO28921.1 - 0.011 16.0 4.8 0.021 15.1 4.8 1.4 1 0 0 1 1 1 0 Ring finger domain zf-RING_5 PF14634.6 ETO28921.1 - 0.02 14.9 4.7 0.043 13.8 4.7 1.6 1 0 0 1 1 1 0 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO28921.1 - 0.033 14.2 6.4 0.068 13.2 6.4 1.5 1 0 0 1 1 1 0 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO28921.1 - 0.072 13.0 2.2 0.12 12.3 2.2 1.3 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO28921.1 - 0.078 12.8 4.8 0.17 11.8 4.8 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO28921.1 - 0.096 12.6 3.8 0.27 11.1 3.8 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Orthopox_F6 PF06601.12 ETO28921.1 - 0.1 12.8 0.9 0.1 12.8 0.9 1.9 2 0 0 2 2 2 0 Orthopoxvirus F6 protein FtsX PF02687.21 ETO28922.1 - 1.2 9.6 3.2 2.2 8.8 3.2 1.3 1 0 0 1 1 1 0 FtsX-like permease family COPI_assoc PF08507.10 ETO28923.1 - 0.0051 16.9 0.0 0.0061 16.6 0.0 1.1 1 0 0 1 1 1 1 COPI associated protein WD40 PF00400.32 ETO28925.1 - 5.9e-06 26.9 1.7 0.31 12.0 0.1 3.8 4 0 0 4 4 4 2 WD domain, G-beta repeat LRR_4 PF12799.7 ETO28926.1 - 1e-14 54.4 52.3 1.4e-05 25.3 2.7 7.7 5 3 1 8 8 8 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO28926.1 - 2.3e-12 46.5 39.6 0.00027 20.6 2.2 6.2 4 2 1 5 5 5 5 Leucine rich repeat LRR_9 PF14580.6 ETO28926.1 - 1.9e-09 37.3 14.4 5.8e-07 29.2 0.5 4.1 4 0 0 4 4 4 3 Leucine-rich repeat LRR_6 PF13516.6 ETO28926.1 - 0.0026 17.7 38.7 0.68 10.1 0.3 10.4 12 0 0 12 12 12 3 Leucine Rich repeat LRR_1 PF00560.33 ETO28926.1 - 0.009 16.4 35.3 1.7 9.5 0.1 10.0 9 2 1 10 10 10 1 Leucine Rich Repeat TPR_12 PF13424.6 ETO28927.1 - 3e-81 267.8 16.1 7.2e-19 67.9 0.0 5.1 1 1 6 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO28927.1 - 4.2e-41 137.7 0.0 1.8e-07 30.8 0.0 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28927.1 - 3.4e-38 126.9 5.3 7.9e-08 31.8 0.1 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28927.1 - 2.2e-37 125.4 34.9 1.2e-08 34.4 0.1 7.4 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28927.1 - 4.4e-30 101.3 21.1 3e-06 26.9 0.6 6.8 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28927.1 - 5.7e-30 101.0 36.3 2.5e-07 30.4 0.2 7.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO28927.1 - 1.7e-21 75.0 5.8 0.014 15.7 0.0 6.8 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO28927.1 - 4.8e-13 49.5 0.0 0.042 14.5 0.0 5.8 5 1 1 6 6 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO28927.1 - 4.9e-12 45.7 2.0 0.0025 18.3 0.1 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO28927.1 - 2.3e-10 40.4 0.0 1 10.4 0.0 5.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO28927.1 - 1.2e-08 34.7 0.0 0.0019 17.6 0.0 2.1 1 1 1 2 2 2 2 MalT-like TPR region PPR PF01535.20 ETO28927.1 - 1.3e-07 31.3 16.4 0.04 14.2 0.1 6.6 7 0 0 7 7 7 2 PPR repeat TPR_3 PF07720.12 ETO28927.1 - 8e-05 22.5 22.6 1.3 9.1 0.5 6.8 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28927.1 - 0.0001 21.9 35.6 0.023 14.4 1.3 7.8 8 3 3 11 11 10 4 TPR repeat ANAPC3 PF12895.7 ETO28927.1 - 0.00012 22.2 17.4 1.1 9.5 0.3 6.2 4 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO28927.1 - 0.00027 20.8 17.4 2.4 7.9 0.4 5.9 4 2 2 6 6 6 1 Domain of unknown function (DUF5113) YecM PF06185.12 ETO28927.1 - 0.00036 20.3 1.4 1.1 8.8 0.0 3.7 2 1 2 4 4 4 1 YecM protein TPR_19 PF14559.6 ETO28927.1 - 0.0085 16.6 2.1 10 6.7 0.0 4.3 3 1 3 6 6 5 0 Tetratricopeptide repeat RPN7 PF10602.9 ETO28927.1 - 0.0093 15.7 7.3 0.23 11.2 1.3 3.6 2 2 1 3 3 3 1 26S proteasome subunit RPN7 DUF3856 PF12968.7 ETO28927.1 - 0.016 15.2 1.8 12 6.0 0.1 3.8 2 1 1 4 4 4 0 Domain of Unknown Function (DUF3856) MIT PF04212.18 ETO28927.1 - 0.024 14.7 19.5 0.81 9.8 0.1 5.8 7 0 0 7 7 6 0 MIT (microtubule interacting and transport) domain bPH_3 PF14470.6 ETO28927.1 - 0.033 14.6 1.8 0.48 10.8 0.1 3.3 1 1 3 4 4 4 0 Bacterial PH domain OrfA PF17495.2 ETO28927.1 - 0.035 14.3 0.0 6.1 7.1 0.0 3.7 1 1 3 4 4 4 0 Vpr-like OrfA KH_4 PF13083.6 ETO28927.1 - 0.085 12.7 0.0 1.4 8.9 0.0 2.4 1 1 1 2 2 2 0 KH domain RAMP4 PF06624.12 ETO28927.1 - 0.22 11.6 0.1 0.22 11.6 0.1 2.1 2 0 0 2 2 1 0 Ribosome associated membrane protein RAMP4 TIR PF01582.20 ETO28928.1 - 0.0072 16.1 0.9 0.013 15.3 0.5 1.5 1 1 0 1 1 1 1 TIR domain S_100 PF01023.19 ETO28928.1 - 0.011 15.4 0.8 2.6 7.8 0.0 2.7 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain DUF4618 PF15397.6 ETO28928.1 - 0.024 14.1 8.7 0.16 11.4 8.4 2.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) SesA PF17107.5 ETO28928.1 - 0.027 14.6 1.0 0.37 11.0 0.0 2.1 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases DUF3106 PF11304.8 ETO28928.1 - 0.032 14.7 4.7 1.9 9.0 1.6 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3106) MbeD_MobD PF04899.12 ETO28928.1 - 0.043 13.9 3.5 7.2 6.8 0.4 3.4 3 1 0 3 3 3 0 MbeD/MobD like DUF615 PF04751.14 ETO28928.1 - 0.068 13.1 4.6 0.15 12.0 3.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF615) DUF5388 PF17363.2 ETO28928.1 - 0.069 13.4 3.1 1.8 8.8 0.5 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5388) OmpH PF03938.14 ETO28928.1 - 0.11 12.8 14.8 0.82 10.0 3.0 2.1 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF2115 PF09888.9 ETO28928.1 - 0.17 12.4 2.2 0.22 12.1 1.6 1.6 1 1 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2115) Myb_DNA-bind_6 PF13921.6 ETO28928.1 - 0.17 12.1 2.0 0.62 10.4 1.7 2.2 1 1 1 2 2 2 0 Myb-like DNA-binding domain Spc7 PF08317.11 ETO28928.1 - 0.29 10.0 13.8 0.75 8.6 12.1 1.9 1 1 1 2 2 2 0 Spc7 kinetochore protein KH_1 PF00013.29 ETO28929.1 - 2e-25 88.4 8.3 1.7e-11 43.7 0.0 4.5 4 0 0 4 4 4 3 KH domain KH_2 PF07650.17 ETO28929.1 - 0.0043 16.8 1.7 9.6 6.1 0.0 3.5 3 0 0 3 3 3 2 KH domain KH_4 PF13083.6 ETO28929.1 - 0.005 16.7 0.1 3 7.8 0.0 2.5 2 0 0 2 2 2 2 KH domain RMI1_C PF16099.5 ETO28929.1 - 0.11 12.3 0.0 0.11 12.3 0.0 2.2 2 0 0 2 2 2 0 Recq-mediated genome instability protein 1, C-terminal OB-fold CCDC53 PF10152.9 ETO28929.1 - 0.69 10.3 17.1 0.43 11.0 3.3 3.0 2 1 0 2 2 2 0 Subunit CCDC53 of WASH complex Zip PF02535.22 ETO28929.1 - 3 7.0 6.5 1.1 8.4 2.1 2.1 2 0 0 2 2 2 0 ZIP Zinc transporter SLAC1 PF03595.17 ETO28930.1 - 2.3 7.4 8.2 3.1 6.9 1.2 2.1 1 1 0 2 2 2 0 Voltage-dependent anion channel CPBP PF02517.16 ETO28931.1 - 1.2e-11 44.9 3.8 1.2e-11 44.9 3.8 1.9 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease p450 PF00067.22 ETO28932.1 - 4.5e-23 81.7 0.0 5.9e-23 81.3 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Nmad4 PF18756.1 ETO28932.1 - 0.055 13.8 0.2 0.13 12.6 0.2 1.5 1 0 0 1 1 1 0 Nucleotide modification associated domain 4 p450 PF00067.22 ETO28933.1 - 3.7e-59 200.7 0.0 4.3e-59 200.5 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Kelch_6 PF13964.6 ETO28934.1 - 7.1e-08 32.5 3.4 0.00032 20.9 0.2 4.1 4 1 1 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO28934.1 - 3.4e-07 30.1 4.4 0.01 15.8 0.2 4.4 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO28934.1 - 0.0002 20.9 5.9 0.12 12.0 0.0 4.3 5 0 0 5 5 5 2 Kelch motif BCHF PF07284.11 ETO28934.1 - 0.0098 15.9 0.5 1.9 8.5 0.0 2.9 4 0 0 4 4 4 1 2-vinyl bacteriochlorophyllide hydratase (BCHF) Kelch_2 PF07646.15 ETO28934.1 - 0.019 14.9 2.8 8.3 6.6 0.3 3.6 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO28934.1 - 0.025 14.8 0.1 0.025 14.8 0.1 3.6 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF4763 PF15960.5 ETO28934.1 - 0.19 11.0 3.6 0.31 10.3 3.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Kelch_5 PF13854.6 ETO28934.1 - 5.1 7.2 9.0 8 6.6 1.0 3.4 4 0 0 4 4 4 0 Kelch motif TLP-20 PF06088.11 ETO28935.1 - 0.011 15.7 2.0 0.016 15.1 2.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) PH PF00169.29 ETO28936.1 - 2.4e-09 37.6 0.1 2.4e-09 37.6 0.1 2.4 3 1 0 3 3 3 1 PH domain PH_11 PF15413.6 ETO28936.1 - 0.00019 21.8 0.2 0.00019 21.8 0.2 3.1 3 1 0 3 3 3 1 Pleckstrin homology domain PH_9 PF15410.6 ETO28936.1 - 0.076 13.4 1.2 0.3 11.5 0.1 2.5 2 1 0 2 2 2 0 Pleckstrin homology domain Seryl_tRNA_N PF02403.22 ETO28937.1 - 0.0078 16.4 4.3 0.0078 16.4 4.3 7.5 3 2 4 7 7 7 1 Seryl-tRNA synthetase N-terminal domain Muted PF14942.6 ETO28937.1 - 0.0096 16.3 7.6 0.0096 16.3 7.6 6.6 4 1 3 7 7 7 1 Organelle biogenesis, Muted-like protein DUF2408 PF10303.9 ETO28937.1 - 0.022 15.3 0.5 0.022 15.3 0.5 5.5 3 1 2 5 5 5 0 Protein of unknown function (DUF2408) Pox_A_type_inc PF04508.12 ETO28937.1 - 0.24 11.3 7.1 0.41 10.6 1.2 4.0 3 0 0 3 3 3 0 Viral A-type inclusion protein repeat Fzo_mitofusin PF04799.13 ETO28941.1 - 0.29 10.7 9.1 0.18 11.4 3.6 2.5 2 1 0 2 2 2 0 fzo-like conserved region ApoO PF09769.9 ETO28941.1 - 0.4 10.7 5.6 0.53 10.3 3.5 2.1 2 0 0 2 2 2 0 Apolipoprotein O LMBR1 PF04791.16 ETO28942.1 - 0.97 8.3 4.8 1 8.2 4.8 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 ETO28942.1 - 1.3 8.5 9.4 1.5 8.3 9.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit HR1 PF02185.16 ETO28942.1 - 2.2 8.5 17.4 3.1 8.0 14.2 2.3 1 1 1 2 2 2 0 Hr1 repeat AAA_23 PF13476.6 ETO28942.1 - 7.3 7.0 11.9 8.8 6.8 11.9 1.1 1 0 0 1 1 1 0 AAA domain Filament PF00038.21 ETO28943.1 - 0.0012 18.5 23.0 0.005 16.5 23.0 2.3 1 1 0 1 1 1 1 Intermediate filament protein DUF883 PF05957.13 ETO28943.1 - 0.16 12.6 6.2 1.8 9.2 1.2 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF883) SHE3 PF17078.5 ETO28943.1 - 0.19 11.4 25.8 0.2 11.3 3.1 2.9 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Jnk-SapK_ap_N PF09744.9 ETO28943.1 - 0.75 10.0 32.6 0.58 10.4 14.1 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Tho2 PF11262.8 ETO28943.1 - 0.87 8.7 22.7 0.4 9.8 12.5 2.1 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 YlqD PF11068.8 ETO28943.1 - 0.93 9.9 29.5 1.2 9.5 12.4 2.3 1 1 0 2 2 2 0 YlqD protein FAM184 PF15665.5 ETO28943.1 - 1.1 9.0 27.1 2.3 7.9 27.1 1.5 1 1 0 1 1 1 0 Family with sequence similarity 184, A and B OGG_N PF07934.12 ETO28943.1 - 2.7 8.1 10.2 14 5.8 10.1 2.3 1 1 1 2 2 2 0 8-oxoguanine DNA glycosylase, N-terminal domain DUF4407 PF14362.6 ETO28943.1 - 5.7 6.2 20.0 28 4.0 20.0 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Cnn_1N PF07989.11 ETO28943.1 - 7.1 6.9 21.9 5.8 7.2 11.5 2.6 1 1 1 2 2 2 0 Centrosomin N-terminal motif 1 GDP_Man_Dehyd PF16363.5 ETO28944.1 - 1.8e-62 211.7 0.0 8.5e-62 209.5 0.0 1.8 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase Epimerase PF01370.21 ETO28944.1 - 1.3e-46 159.0 0.0 2.4e-45 154.9 0.0 2.1 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO28944.1 - 2.8e-13 49.5 0.0 9.6e-13 47.8 0.0 1.7 1 1 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Polysacc_synt_2 PF02719.15 ETO28944.1 - 7.4e-11 41.7 0.0 6.9e-09 35.3 0.0 2.4 1 1 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ETO28944.1 - 2.8e-10 39.8 0.1 8.4e-09 35.0 0.1 2.7 1 1 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 ETO28944.1 - 8.7e-07 28.3 0.0 6.1e-06 25.5 0.0 2.0 1 1 0 1 1 1 1 RmlD substrate binding domain IU_nuc_hydro PF01156.19 ETO28945.1 - 6.2e-12 45.7 0.0 8.5e-12 45.3 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase SPOC PF07744.13 ETO28947.1 - 2.7e-06 27.3 0.1 6e-06 26.2 0.1 1.6 1 0 0 1 1 1 1 SPOC domain NIF PF03031.18 ETO28947.1 - 0.016 15.0 2.4 0.016 15.0 2.4 2.2 2 0 0 2 2 2 0 NLI interacting factor-like phosphatase Phage_int_SAM_6 PF18644.1 ETO28948.1 - 0.0025 17.9 0.2 0.003 17.6 0.2 1.1 1 0 0 1 1 1 1 Phage integrase SAM-like domain V-ATPase_H_N PF03224.14 ETO28948.1 - 0.033 13.5 0.6 0.04 13.2 0.6 1.0 1 0 0 1 1 1 0 V-ATPase subunit H NT-C2 PF10358.9 ETO28949.1 - 1.2e-08 34.8 8.8 2.6e-08 33.7 8.8 1.6 1 1 0 1 1 1 1 N-terminal C2 in EEIG1 and EHBP1 proteins Secretin_N_2 PF07655.13 ETO28949.1 - 1.3 9.6 22.1 3 8.4 22.1 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Orf78 PF06024.12 ETO28949.1 - 1.6 9.0 5.6 15 5.9 3.8 2.5 2 0 0 2 2 2 0 Orf78 (ac78) 5-FTHF_cyc-lig PF01812.20 ETO28950.1 - 1.3e-24 87.1 0.0 2.4e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 5-formyltetrahydrofolate cyclo-ligase family Xrn1_D3 PF18194.1 ETO28950.1 - 0.01 15.9 0.3 0.094 12.8 0.0 2.5 2 0 0 2 2 2 0 Exoribonuclease 1 Domain-3 DUF2121 PF09894.9 ETO28950.1 - 0.36 10.3 4.0 0.49 9.9 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2121) CSN7a_helixI PF18392.1 ETO28951.1 - 1.1 9.2 7.2 0.24 11.3 1.1 2.7 2 0 0 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain ALMT PF11744.8 ETO28951.1 - 1.2 7.9 9.9 1.4 7.7 9.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CTU2 PF10288.9 ETO28951.1 - 2.5 8.4 12.0 5.5 7.3 12.0 1.5 1 0 0 1 1 1 0 Cytoplasmic tRNA 2-thiolation protein 2 Tox-ODYAM1 PF15642.6 ETO28951.1 - 3 6.7 14.6 0.14 11.1 8.1 1.9 1 1 1 2 2 2 0 Toxin in Odyssella and Amoebophilus Folliculin PF11704.8 ETO28951.1 - 4.8 7.0 10.5 42 3.9 10.5 2.1 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Peptidase_M20 PF01546.28 ETO28953.1 - 2.6e-19 69.7 0.0 3.8e-19 69.2 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETO28953.1 - 0.00011 22.1 0.0 0.00044 20.1 0.0 1.9 1 1 0 1 1 1 1 Peptidase dimerisation domain ABC_tran PF00005.27 ETO28954.1 - 9.4e-27 94.2 0.0 1.2e-26 93.8 0.0 1.1 1 0 0 1 1 1 1 ABC transporter AAA_23 PF13476.6 ETO28954.1 - 0.0016 19.0 0.1 0.0026 18.3 0.1 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ETO28954.1 - 0.0049 16.2 0.0 0.0075 15.6 0.0 1.2 1 0 0 1 1 1 1 Zeta toxin AAA_30 PF13604.6 ETO28954.1 - 0.008 15.9 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO28954.1 - 0.012 15.6 0.1 0.017 15.0 0.1 1.2 1 0 0 1 1 1 0 RsgA GTPase SRP54 PF00448.22 ETO28954.1 - 0.012 15.3 0.2 0.022 14.4 0.2 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain AAA_29 PF13555.6 ETO28954.1 - 0.041 13.6 0.1 0.088 12.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_21 PF13304.6 ETO28954.1 - 0.11 12.3 0.0 0.91 9.3 0.0 2.0 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_24 PF13479.6 ETO28954.1 - 0.14 11.9 0.0 0.24 11.1 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO28954.1 - 0.15 12.1 0.2 0.25 11.4 0.2 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_15 PF13175.6 ETO28954.1 - 0.18 11.5 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain SMC_N PF02463.19 ETO28954.1 - 0.22 11.0 0.2 7.7 5.9 0.0 2.1 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain ABC2_membrane_3 PF12698.7 ETO28955.1 - 1.8e-33 116.1 20.3 3e-33 115.4 20.3 1.4 1 1 0 1 1 1 1 ABC-2 family transporter protein YajC PF02699.15 ETO28955.1 - 0.13 12.1 1.2 10 6.1 0.1 2.8 2 0 0 2 2 2 0 Preprotein translocase subunit DUF3087 PF11286.8 ETO28955.1 - 0.3 10.5 1.6 0.56 9.6 1.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3087) ABC2_membrane_2 PF12679.7 ETO28955.1 - 1.7 7.9 22.2 1.4 8.1 19.9 2.1 2 1 0 2 2 2 0 ABC-2 family transporter protein TMEM192 PF14802.6 ETO28955.1 - 2.2 7.3 5.9 0.57 9.2 0.1 2.3 1 1 0 2 2 2 0 TMEM192 family DUF4131 PF13567.6 ETO28955.1 - 2.5 7.7 7.4 6.2 6.4 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4131) PH PF00169.29 ETO28956.1 - 0.041 14.4 0.5 0.08 13.5 0.1 1.6 2 0 0 2 2 2 0 PH domain Afaf PF15339.6 ETO28956.1 - 0.55 9.9 2.0 0.82 9.4 2.0 1.2 1 0 0 1 1 1 0 Acrosome formation-associated factor MBT PF02820.18 ETO28957.1 - 0.0085 16.4 0.0 0.024 15.0 0.0 1.7 1 0 0 1 1 1 1 mbt repeat CDC45 PF02724.14 ETO28957.1 - 0.023 13.0 1.6 0.032 12.6 1.6 1.1 1 0 0 1 1 1 0 CDC45-like protein PDE6_gamma PF04868.12 ETO28957.1 - 0.05 13.8 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 Retinal cGMP phosphodiesterase, gamma subunit Tudor-knot PF11717.8 ETO28957.1 - 0.051 13.5 0.2 0.19 11.6 0.2 2.0 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain Menin PF05053.13 ETO28957.1 - 0.26 9.6 8.5 0.4 9.0 8.5 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO28957.1 - 0.73 8.5 6.0 1.2 7.8 6.0 1.2 1 0 0 1 1 1 0 Presenilin POT1 PF02765.17 ETO28958.1 - 0.00019 21.3 0.0 0.0003 20.6 0.0 1.3 1 0 0 1 1 1 1 Telomeric single stranded DNA binding POT1/CDC13 PAS_11 PF14598.6 ETO28958.1 - 0.019 15.1 0.0 0.044 13.9 0.0 1.6 1 0 0 1 1 1 0 PAS domain NAD_binding_4 PF07993.12 ETO28958.1 - 0.11 11.7 0.0 0.16 11.1 0.0 1.3 1 0 0 1 1 1 0 Male sterility protein Churchill PF06573.11 ETO28959.1 - 1.2e-31 109.3 12.0 1.2e-31 109.3 12.0 1.8 2 0 0 2 2 2 1 Churchill protein TPR_1 PF00515.28 ETO28959.1 - 2.2e-10 39.9 0.5 0.00017 21.2 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28959.1 - 6.7e-08 32.1 0.2 0.0015 18.5 0.0 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28959.1 - 4.9e-05 23.2 0.4 0.089 13.0 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO28959.1 - 0.00023 21.4 0.1 0.034 14.4 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO28959.1 - 0.00047 19.8 0.2 0.49 10.1 0.0 2.5 1 1 1 2 2 2 2 TPR repeat TPR_19 PF14559.6 ETO28959.1 - 0.14 12.7 0.0 0.44 11.1 0.0 1.8 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO28959.1 - 0.16 12.1 0.0 0.34 11.1 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Mito_carr PF00153.27 ETO28960.1 - 4.8e-22 77.7 0.2 2.8e-13 49.6 0.0 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein UcrQ PF02939.16 ETO28960.1 - 0.17 11.8 0.4 10 6.2 0.0 3.0 3 0 0 3 3 3 0 UcrQ family TPR_12 PF13424.6 ETO28961.1 - 5.5e-59 196.4 4.6 1.8e-17 63.4 0.2 4.4 2 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO28961.1 - 1.2e-43 145.8 0.0 2.1e-09 36.9 0.0 6.9 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO28961.1 - 1.5e-39 132.2 27.1 3.4e-09 36.1 0.8 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO28961.1 - 2.4e-37 124.0 26.8 1.5e-06 27.9 0.3 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO28961.1 - 2.4e-35 117.9 2.7 6.2e-07 29.0 0.0 6.6 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO28961.1 - 8e-30 100.5 22.1 0.00013 21.8 0.0 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO28961.1 - 7.2e-14 51.1 12.0 0.027 14.8 0.3 7.0 5 1 1 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO28961.1 - 1e-09 38.4 6.5 0.96 10.2 0.1 6.3 6 0 0 6 6 6 2 Tetratricopeptide repeat SNAP PF14938.6 ETO28961.1 - 6.7e-09 35.6 3.5 8.6e-07 28.7 1.2 2.4 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_11 PF13414.6 ETO28961.1 - 1.9e-08 33.8 30.5 0.15 11.7 0.1 8.7 6 4 3 9 9 9 4 TPR repeat TPR_14 PF13428.6 ETO28961.1 - 1.5e-06 28.5 0.1 1.1e+02 4.1 0.0 6.3 6 0 0 6 6 6 0 Tetratricopeptide repeat MIT PF04212.18 ETO28961.1 - 6.6e-06 26.1 5.5 0.48 10.5 0.0 5.2 4 1 2 6 6 6 2 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 ETO28961.1 - 1.3e-05 25.7 0.1 4.2 8.1 0.0 5.3 2 2 2 4 4 4 1 Tetratricopeptide repeat DUF627 PF04781.12 ETO28961.1 - 0.00024 21.1 0.9 0.98 9.5 0.0 3.8 3 1 0 3 3 3 1 Protein of unknown function (DUF627) TPR_MalT PF17874.1 ETO28961.1 - 0.00033 20.1 0.0 0.00061 19.3 0.0 1.4 1 1 0 1 1 1 1 MalT-like TPR region DUF5113 PF17140.4 ETO28961.1 - 0.0013 18.6 7.9 0.47 10.2 0.2 4.5 3 2 1 4 4 4 1 Domain of unknown function (DUF5113) HTH_Bact PF18768.1 ETO28961.1 - 0.0017 17.9 3.8 0.69 9.5 0.2 4.4 4 0 0 4 4 4 1 Helix-turn-helix bacterial domain mit_SMPDase PF14724.6 ETO28961.1 - 0.0018 16.3 0.1 0.045 11.7 0.0 2.2 1 1 1 2 2 2 1 Mitochondrial-associated sphingomyelin phosphodiesterase NRBF2_MIT PF17169.4 ETO28961.1 - 0.0067 16.6 0.8 13 6.1 0.0 4.2 3 1 1 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 SLT PF01464.20 ETO28961.1 - 0.021 14.5 2.6 4.9 6.8 0.0 3.6 3 1 2 5 5 4 0 Transglycosylase SLT domain Mistic PF11458.8 ETO28961.1 - 0.031 14.2 2.1 16 5.5 0.0 3.9 4 0 0 4 4 3 0 Membrane-integrating protein Mistic Cytochrom_CIII PF02085.16 ETO28961.1 - 0.066 13.6 3.0 0.31 11.4 1.5 2.4 2 0 0 2 2 2 0 Class III cytochrome C family SPO22 PF08631.10 ETO28961.1 - 0.11 12.0 2.3 3.4 7.1 0.2 2.8 1 1 2 3 3 3 0 Meiosis protein SPO22/ZIP4 like TPR_19 PF14559.6 ETO28961.1 - 0.12 13.0 0.7 24 5.5 0.0 4.0 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO28961.1 - 1.7 8.7 22.9 1.8 8.7 0.2 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO28961.1 - 2.9 8.7 12.2 26 5.7 0.5 5.8 6 1 0 6 6 6 0 Sel1 repeat WD40 PF00400.32 ETO28962.1 - 6.2e-61 200.9 22.2 7.1e-10 39.3 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO28962.1 - 1.1e-21 76.9 1.7 0.0015 18.7 0.0 6.7 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO28962.1 - 2.3e-16 59.7 0.9 0.0038 16.3 0.0 5.8 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO28962.1 - 1.7e-09 37.4 0.7 0.00015 21.2 0.3 3.4 1 1 3 4 4 4 3 WD40-like domain Nbas_N PF15492.6 ETO28962.1 - 2.7e-07 30.2 2.2 0.8 9.0 0.0 5.0 1 1 4 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO28962.1 - 7.4e-07 28.2 4.7 0.24 10.0 0.2 5.3 1 1 4 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO28962.1 - 9.3e-05 21.1 0.2 0.098 11.2 0.0 2.7 1 1 3 4 4 4 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO28962.1 - 0.00019 21.5 3.3 4.6 7.4 0.1 4.7 1 1 3 5 5 5 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO28962.1 - 0.0023 17.8 8.9 1.2 9.1 0.0 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO28962.1 - 0.0071 16.0 7.3 14 5.4 0.1 5.3 5 0 0 5 5 5 1 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO28962.1 - 0.055 13.4 0.0 47 4.2 0.0 3.8 3 0 0 3 3 3 0 PQQ enzyme repeat Pkinase PF00069.25 ETO28964.1 - 3.9e-43 147.7 0.0 6.4e-43 147.0 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO28964.1 - 5.6e-31 107.8 0.1 1.2e-29 103.5 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO28964.1 - 1e-05 24.5 1.2 1.2e-05 24.3 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kinase-like PF14531.6 ETO28964.1 - 3.5e-05 23.3 0.0 5e-05 22.8 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO28964.1 - 0.0038 16.6 0.0 0.0073 15.7 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Hydrolase_4 PF12146.8 ETO28965.1 - 1.4e-16 60.5 0.2 3.3e-07 29.8 0.0 2.3 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO28965.1 - 8.2e-10 38.8 0.3 5.4e-09 36.1 0.3 2.0 1 1 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO28965.1 - 6.9e-08 33.4 0.1 1.3e-06 29.2 0.1 2.1 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ETO28965.1 - 0.017 14.7 1.4 0.58 9.7 0.0 2.5 2 1 1 3 3 3 0 Dienelactone hydrolase family Acyl_transf_2 PF02273.15 ETO28965.1 - 0.035 13.3 0.2 0.098 11.9 0.0 1.8 2 0 0 2 2 2 0 Acyl transferase Peptidase_S9 PF00326.21 ETO28965.1 - 0.066 12.7 0.2 0.75 9.2 0.0 2.5 3 0 0 3 3 3 0 Prolyl oligopeptidase family BAAT_C PF08840.11 ETO28965.1 - 0.072 13.0 1.2 12 5.7 0.1 2.6 3 0 0 3 3 3 0 BAAT / Acyl-CoA thioester hydrolase C terminal UPF0227 PF05728.12 ETO28965.1 - 0.077 12.9 0.1 0.16 11.9 0.1 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) DRMBL PF07522.14 ETO28966.1 - 5.6e-21 74.8 2.9 1.2e-19 70.5 1.4 2.9 2 1 0 2 2 2 1 DNA repair metallo-beta-lactamase RMMBL PF07521.12 ETO28966.1 - 0.11 12.4 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 Zn-dependent metallo-hydrolase RNA specificity domain zf-C3HC4_3 PF13920.6 ETO28967.1 - 2.8e-11 43.1 10.6 2.8e-11 43.1 10.6 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO28967.1 - 1.1e-08 34.8 10.3 2.4e-08 33.7 10.3 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ETO28967.1 - 0.00062 19.7 12.0 0.00062 19.7 12.0 1.9 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETO28967.1 - 0.00074 19.8 12.4 0.00074 19.8 12.4 1.7 2 0 0 2 2 1 1 Ring finger domain DUF913 PF06025.12 ETO28967.1 - 0.016 14.2 12.2 0.079 11.9 6.4 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) zf-C3HC4_2 PF13923.6 ETO28967.1 - 0.026 14.4 12.7 0.026 14.4 12.7 1.7 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DUF5523 PF17661.1 ETO28967.1 - 0.055 13.2 32.7 0.079 12.6 17.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5523) CobT PF06213.12 ETO28967.1 - 0.057 12.8 33.2 0.022 14.2 21.8 2.1 2 0 0 2 2 2 0 Cobalamin biosynthesis protein CobT SDA1 PF05285.12 ETO28967.1 - 0.31 10.4 40.7 0.045 13.2 24.9 2.1 2 0 0 2 2 2 0 SDA1 zf-P11 PF03854.14 ETO28967.1 - 0.34 10.6 6.6 0.69 9.6 6.6 1.4 1 0 0 1 1 1 0 P-11 zinc finger GEMIN8 PF15348.6 ETO28967.1 - 1.2 9.4 22.8 3.8 7.7 13.7 2.2 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 MID_MedPIWI PF18296.1 ETO28967.1 - 1.4 8.7 11.3 0.11 12.3 3.8 2.0 2 0 0 2 2 2 0 MID domain of medPIWI EOS1 PF12326.8 ETO28967.1 - 1.9 8.4 8.5 0.89 9.5 0.4 2.3 2 0 0 2 2 2 0 N-glycosylation protein DNA_pol_phi PF04931.13 ETO28967.1 - 2 6.4 31.1 0.068 11.3 22.4 2.2 2 0 0 2 2 2 0 DNA polymerase phi zf-RING_UBOX PF13445.6 ETO28967.1 - 3.4 7.8 9.1 9.7 6.3 4.2 2.7 2 0 0 2 2 2 0 RING-type zinc-finger SLC12 PF03522.15 ETO28967.1 - 4.8 6.1 22.4 4.2 6.3 1.7 2.1 2 0 0 2 2 2 0 Solute carrier family 12 XRN_M PF17846.1 ETO28967.1 - 5.4 5.9 27.9 0.074 12.0 14.2 2.1 2 0 0 2 2 2 0 Xrn1 helical domain Band_3_cyto PF07565.13 ETO28967.1 - 5.4 6.7 13.9 1.2 8.9 3.9 2.1 2 0 0 2 2 2 0 Band 3 cytoplasmic domain FAM60A PF15396.6 ETO28967.1 - 6 6.8 21.2 1.9 8.5 8.4 2.2 2 0 0 2 2 2 0 Protein Family FAM60A RR_TM4-6 PF06459.12 ETO28967.1 - 6.1 6.6 33.5 0.69 9.7 15.2 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 RPN2_C PF18004.1 ETO28967.1 - 6.3 6.7 38.9 1.1 9.2 17.3 2.4 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain PPP4R2 PF09184.11 ETO28967.1 - 6.6 6.2 35.8 1.1 8.8 26.1 2.1 2 0 0 2 2 2 0 PPP4R2 PCM1_C PF15717.5 ETO28967.1 - 9 4.9 29.4 0.15 10.7 16.8 2.0 2 0 0 2 2 2 0 Pericentriolar material 1 C terminus Menin PF05053.13 ETO28967.1 - 9.4 4.5 17.0 1.4 7.2 9.2 2.1 2 0 0 2 2 2 0 Menin H_PPase PF03030.16 ETO28968.1 - 0.031 12.9 0.9 0.035 12.7 0.9 1.1 1 0 0 1 1 1 0 Inorganic H+ pyrophosphatase DUF4083 PF13314.6 ETO28968.1 - 0.63 10.0 0.0 0.63 10.0 0.0 3.2 3 1 1 4 4 4 0 Domain of unknown function (DUF4083) DUF2304 PF10066.9 ETO28968.1 - 8.9 6.6 11.6 1 9.6 5.1 2.5 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2304) Bromodomain PF00439.25 ETO28969.1 - 2.9e-24 85.0 0.0 8.1e-24 83.5 0.0 1.8 1 0 0 1 1 1 1 Bromodomain BET PF17035.5 ETO28969.1 - 1.5e-12 47.5 1.2 2.8e-12 46.6 1.2 1.5 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Nop16 PF09420.10 ETO28969.1 - 0.00087 19.4 2.6 0.0014 18.7 2.6 1.3 1 0 0 1 1 1 1 Ribosome biogenesis protein Nop16 OsmC PF02566.19 ETO28969.1 - 0.095 13.2 0.1 0.17 12.4 0.1 1.4 1 0 0 1 1 1 0 OsmC-like protein WASH_WAHD PF11945.8 ETO28971.1 - 1.3e-37 129.9 0.8 1.8e-37 129.4 0.8 1.1 1 0 0 1 1 1 1 WAHD domain of WASH complex Cation_ATPase_C PF00689.21 ETO28972.1 - 1.1e-38 132.8 5.9 1.1e-38 132.8 5.9 2.5 2 1 0 2 2 2 1 Cation transporting ATPase, C-terminus E1-E2_ATPase PF00122.20 ETO28972.1 - 6e-20 71.5 0.3 1.3e-19 70.4 0.3 1.6 1 0 0 1 1 1 1 E1-E2 ATPase Hydrolase PF00702.26 ETO28972.1 - 6.6e-20 72.3 2.2 5.8e-10 39.8 0.8 3.5 2 1 0 2 2 2 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO28972.1 - 5.5e-13 48.8 0.1 1.4e-12 47.5 0.1 1.7 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETO28972.1 - 4.3e-06 26.6 6.2 0.0012 18.6 1.4 2.8 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase HAD PF12710.7 ETO28972.1 - 0.0019 18.6 0.0 0.018 15.5 0.0 2.3 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase ubiquitin PF00240.23 ETO28972.1 - 0.0038 17.0 0.0 0.0096 15.7 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Hydrolase_6 PF13344.6 ETO28972.1 - 0.044 13.9 0.0 0.14 12.3 0.0 1.8 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase MreB_Mbl PF06723.13 ETO28973.1 - 0.048 12.5 1.0 3.7 6.3 0.0 2.6 3 0 0 3 3 3 0 MreB/Mbl protein Ammonium_transp PF00909.21 ETO28974.1 - 2.7e-07 29.6 0.0 3.2e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Ammonium Transporter Family Ank_2 PF12796.7 ETO28974.1 - 6.3e-05 23.5 0.0 9.7e-05 22.9 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO28974.1 - 0.00016 21.9 0.1 0.00048 20.4 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_3 PF13606.6 ETO28974.1 - 0.0015 18.8 0.1 0.0047 17.3 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeat Ank_5 PF13857.6 ETO28974.1 - 0.0033 17.7 0.1 0.0081 16.5 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO28974.1 - 0.0053 17.3 0.0 0.015 15.9 0.0 1.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) PBECR1 PF18809.1 ETO28975.1 - 0.14 12.8 0.9 0.49 11.1 0.0 2.2 3 0 0 3 3 3 0 phage-Barnase-EndoU-ColicinE5/D-RelE like nuclease1 XK-related PF09815.9 ETO28976.1 - 2.7e-07 30.0 32.5 2.7e-07 30.0 32.5 1.9 1 1 0 1 1 1 1 XK-related protein NDUF_B8 PF05821.11 ETO28976.1 - 0.02 14.8 0.2 0.038 13.8 0.2 1.6 1 0 0 1 1 1 0 NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8) Tir_receptor_C PF07489.11 ETO28976.1 - 0.29 11.1 3.0 0.41 10.6 3.0 1.1 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Cwf_Cwc_15 PF04889.12 ETO28977.1 - 0.00018 21.4 6.6 0.00018 21.4 6.6 2.0 2 0 0 2 2 2 1 Cwf15/Cwc15 cell cycle control protein PBP1_TM PF14812.6 ETO28977.1 - 0.0047 17.3 15.6 0.0047 17.3 15.6 2.2 3 0 0 3 3 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal FAM176 PF14851.6 ETO28977.1 - 0.009 15.7 0.6 0.009 15.7 0.6 1.9 2 0 0 2 2 2 1 FAM176 family Myc_N PF01056.18 ETO28977.1 - 0.036 14.0 0.5 0.068 13.1 0.5 1.4 1 0 0 1 1 1 0 Myc amino-terminal region Nop14 PF04147.12 ETO28977.1 - 0.18 10.0 8.4 0.32 9.1 8.4 1.3 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 ETO28977.1 - 0.54 9.8 10.1 0.08 12.5 6.1 1.6 2 0 0 2 2 2 0 PPP4R2 NOA36 PF06524.12 ETO28977.1 - 0.69 9.2 20.4 1.3 8.3 20.4 1.3 1 0 0 1 1 1 0 NOA36 protein RXT2_N PF08595.11 ETO28977.1 - 0.93 9.5 10.2 0.05 13.6 4.6 1.7 2 0 0 2 2 2 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 ETO28977.1 - 1.3 8.8 7.5 3 7.7 7.5 1.5 1 0 0 1 1 1 0 Sigma-70, non-essential region CNDH2_C PF16858.5 ETO28977.1 - 3.8 7.3 17.3 22 4.8 17.3 1.9 1 1 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Vfa1 PF08432.10 ETO28977.1 - 4.9 7.4 9.3 2.7 8.3 1.9 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Glu_synthase PF01645.17 ETO28977.1 - 5.4 6.0 5.9 0.43 9.7 0.8 1.6 2 0 0 2 2 2 0 Conserved region in glutamate synthase Pox_Ag35 PF03286.14 ETO28977.1 - 9.2 6.0 10.4 1.6 8.4 3.9 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Glyco_hydro_53 PF07745.13 ETO28983.1 - 6.4e-21 74.7 0.0 7.6e-21 74.5 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 53 Dicty_REP PF05086.12 ETO28984.1 - 0.0044 15.1 4.6 0.0051 14.9 4.6 1.0 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein DUF3439 PF11921.8 ETO28984.1 - 0.04 13.9 2.4 0.061 13.3 2.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Tir_receptor_C PF07489.11 ETO28984.1 - 0.14 12.1 2.7 0.18 11.8 2.7 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus RPN2_C PF18004.1 ETO28985.1 - 0.0035 17.3 3.5 0.0035 17.3 3.5 2.9 3 0 0 3 3 3 1 26S proteasome regulatory subunit RPN2 C-terminal domain FAM176 PF14851.6 ETO28985.1 - 0.013 15.2 1.9 0.013 15.2 1.9 2.3 2 0 0 2 2 2 0 FAM176 family DUF1754 PF08555.10 ETO28985.1 - 0.044 14.6 5.0 0.044 14.6 5.0 2.4 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) ORC_WH_C PF18137.1 ETO28985.1 - 0.25 11.4 0.1 0.25 11.4 0.1 2.6 2 1 0 2 2 1 0 Origin recognition complex winged helix C-terminal Connexin PF00029.19 ETO28985.1 - 0.78 9.5 7.0 0.44 10.3 0.8 2.3 2 0 0 2 2 2 0 Connexin Vfa1 PF08432.10 ETO28985.1 - 0.79 10.0 24.7 1.5 9.1 7.4 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 SpoIIIAH PF12685.7 ETO28985.1 - 2.1 8.1 14.5 1.3 8.8 1.0 2.1 2 0 0 2 2 2 0 SpoIIIAH-like protein DUF3504 PF12012.8 ETO28985.1 - 2.2 8.1 7.8 0.31 11.0 1.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3504) RNA_pol_Rpc4 PF05132.14 ETO28985.1 - 3.6 8.0 13.1 1.3 9.4 0.4 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 Afi1 PF07792.12 ETO28985.1 - 4.7 7.7 13.8 2.3 8.7 3.2 2.5 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking CLN3 PF02487.17 ETO28985.1 - 5.6 5.9 6.6 0.35 9.8 0.2 1.9 2 0 0 2 2 2 0 CLN3 protein CPSF100_C PF13299.6 ETO28985.1 - 8 6.6 14.3 3 8.0 2.4 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Rtf2 PF04641.12 ETO28985.1 - 8.5 5.6 22.1 1.3 8.3 4.3 2.2 2 0 0 2 2 2 0 Rtf2 RING-finger Stealth_CR4 PF17103.5 ETO28987.1 - 0.049 13.5 0.2 0.18 11.7 0.2 2.0 1 0 0 1 1 1 0 Stealth protein CR4, conserved region 4 HeLo PF14479.6 ETO28987.1 - 0.18 11.6 2.5 0.18 11.6 0.1 2.3 3 0 0 3 3 3 0 Prion-inhibition and propagation TFIIF_alpha PF05793.12 ETO28988.1 - 0.013 14.1 26.0 0.017 13.8 26.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Atrophin-1 PF03154.15 ETO28988.1 - 0.014 13.8 9.6 0.014 13.7 9.6 1.1 1 0 0 1 1 1 0 Atrophin-1 family BUD22 PF09073.10 ETO28988.1 - 0.016 14.6 18.7 0.02 14.3 18.7 1.2 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO28988.1 - 0.029 12.6 16.0 0.034 12.4 16.0 1.1 1 0 0 1 1 1 0 Nop14-like family CDC27 PF09507.10 ETO28988.1 - 0.042 13.2 18.2 0.062 12.7 18.2 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 FAM60A PF15396.6 ETO28988.1 - 0.045 13.8 8.0 0.059 13.4 8.0 1.3 1 0 0 1 1 1 0 Protein Family FAM60A RNA_pol_3_Rpc31 PF11705.8 ETO28988.1 - 0.061 13.6 21.5 0.099 12.9 21.5 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Pox_Ag35 PF03286.14 ETO28988.1 - 0.093 12.5 15.4 0.17 11.7 15.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PPL5 PF18168.1 ETO28988.1 - 0.13 11.6 13.1 0.2 10.9 13.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 TT_ORF2 PF02957.15 ETO28988.1 - 0.15 13.0 9.9 0.29 12.1 9.9 1.4 1 0 0 1 1 1 0 TT viral ORF2 FYDLN_acid PF09538.10 ETO28988.1 - 0.17 12.6 18.5 0.34 11.6 18.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Dicty_REP PF05086.12 ETO28988.1 - 0.21 9.5 13.9 0.28 9.1 13.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PPP4R2 PF09184.11 ETO28988.1 - 0.43 10.1 22.2 0.71 9.4 22.2 1.3 1 0 0 1 1 1 0 PPP4R2 DUF4746 PF15928.5 ETO28988.1 - 0.74 9.2 12.3 1.2 8.5 12.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Cwf_Cwc_15 PF04889.12 ETO28988.1 - 0.75 9.5 21.9 1.2 8.9 21.9 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein COPI_C PF06957.11 ETO28988.1 - 0.89 8.2 7.7 1.2 7.8 7.7 1.1 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus Vfa1 PF08432.10 ETO28988.1 - 1.5 9.1 18.1 2.8 8.2 18.1 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3987 PF13148.6 ETO28988.1 - 1.6 7.7 6.2 5 6.0 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3987) PBP_sp32 PF07222.12 ETO28988.1 - 1.9 7.9 9.2 4.5 6.7 9.2 1.6 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Presenilin PF01080.17 ETO28988.1 - 3.1 6.4 9.8 3.9 6.1 9.8 1.1 1 0 0 1 1 1 0 Presenilin Afi1 PF07792.12 ETO28988.1 - 4.1 7.9 19.2 17 5.9 19.1 2.0 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FGF-BP1 PF06473.12 ETO28988.1 - 5.4 6.8 12.2 8.5 6.1 12.2 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) NOA36 PF06524.12 ETO28988.1 - 7.2 5.8 22.4 11 5.3 22.4 1.2 1 0 0 1 1 1 0 NOA36 protein Metallophos PF00149.28 ETO28989.1 - 0.00079 20.0 2.5 0.0016 19.0 2.5 1.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase CAP_GLY PF01302.25 ETO28990.1 - 1.4e-24 85.8 2.2 1.4e-17 63.5 0.3 3.2 2 1 0 2 2 2 2 CAP-Gly domain Mucin PF01456.17 ETO28990.1 - 0.23 11.4 25.4 0.41 10.6 25.4 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein Dicty_REP PF05086.12 ETO28990.1 - 0.8 7.6 8.5 1.2 7.0 8.5 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 ETO28990.1 - 1.2 7.1 10.6 1.9 6.5 10.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus CDC45 PF02724.14 ETO28991.1 - 1.4 7.1 18.2 0.41 8.9 15.0 1.6 2 0 0 2 2 2 0 CDC45-like protein FAM176 PF14851.6 ETO28991.1 - 9.4 5.9 8.6 24 4.6 8.6 1.8 1 0 0 1 1 1 0 FAM176 family DMP12 PF16779.5 ETO28993.1 - 0.077 13.0 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 DNA-mimic protein LRR_RI_capping PF18779.1 ETO28994.1 - 0.089 12.5 0.1 0.2 11.3 0.1 1.5 1 0 0 1 1 1 0 Capping Ribonuclease inhibitor Leucine Rich Repeat UDG PF03167.19 ETO28995.1 - 1.1e-21 77.5 0.0 2.1e-21 76.5 0.0 1.4 1 0 0 1 1 1 1 Uracil DNA glycosylase superfamily His_Phos_1 PF00300.22 ETO28997.1 - 4.3e-08 33.1 0.3 0.011 15.5 0.0 3.4 3 1 0 3 3 3 3 Histidine phosphatase superfamily (branch 1) KI67R PF08065.12 ETO28999.1 - 0.75 10.4 5.4 0.4 11.3 0.3 2.7 2 1 0 2 2 2 0 KI67R (NUC007) repeat Prok-RING_1 PF14446.6 ETO29000.1 - 0.024 14.6 15.0 0.23 11.4 3.9 2.7 2 1 0 2 2 2 0 Prokaryotic RING finger family 1 Se-cys_synth_N PF12390.8 ETO29000.1 - 0.035 14.3 0.0 0.093 13.0 0.0 1.7 2 0 0 2 2 2 0 Selenocysteine synthase N terminal ZZ PF00569.17 ETO29000.1 - 0.19 11.6 18.1 0.13 12.1 2.1 3.4 2 2 0 2 2 2 0 Zinc finger, ZZ type Merozoite_SPAM PF07133.11 ETO29000.1 - 2.1 8.3 24.7 3.1 7.8 24.7 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Spt5_N PF11942.8 ETO29000.1 - 4.7 8.3 17.3 9 7.4 17.3 1.4 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal LANC_like PF05147.13 ETO29001.1 - 2.4e-34 118.5 1.0 2.8e-34 118.2 1.0 1.0 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein Peptidase_S46 PF10459.9 ETO29001.1 - 0.2 10.3 0.1 0.27 9.8 0.1 1.1 1 0 0 1 1 1 0 Peptidase S46 Kelch_6 PF13964.6 ETO29002.1 - 5.2e-09 36.1 5.4 0.0026 18.0 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO29002.1 - 6.2e-05 23.2 0.0 0.011 16.1 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO29002.1 - 0.0024 17.4 3.8 0.16 11.6 0.1 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO29002.1 - 0.017 15.1 5.0 9 6.4 0.2 4.2 5 0 0 5 5 5 0 Kelch motif Kelch_4 PF13418.6 ETO29002.1 - 0.019 15.0 3.5 0.096 12.7 0.0 3.5 4 0 0 4 4 4 0 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO29002.1 - 0.027 13.6 0.2 2.5 7.2 0.0 2.3 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_2 PF07646.15 ETO29002.1 - 0.046 13.7 3.0 24 5.1 0.1 4.3 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO29003.1 - 2.1e-63 208.7 17.5 2.9e-09 37.4 0.1 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29003.1 - 1e-15 57.8 1.4 0.0015 18.8 0.1 5.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29003.1 - 1.5e-13 50.5 2.0 0.069 12.1 0.0 6.3 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29003.1 - 5.3e-07 29.3 0.5 0.0022 17.4 0.2 3.3 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO29003.1 - 0.0001 21.1 8.2 0.094 11.3 0.9 4.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 RE_XamI PF09572.10 ETO29003.1 - 0.0037 17.0 0.0 0.021 14.5 0.0 2.0 2 0 0 2 2 2 1 XamI restriction endonuclease Utp8 PF10395.9 ETO29003.1 - 0.0072 14.9 0.1 0.015 13.8 0.1 1.5 1 1 0 1 1 1 1 Utp8 family Cytochrom_D1 PF02239.16 ETO29003.1 - 0.01 14.4 1.3 0.54 8.7 0.4 2.5 1 1 1 2 2 2 0 Cytochrome D1 heme domain Resistin PF06954.11 ETO29003.1 - 0.042 14.4 0.0 1e+02 3.5 0.0 3.9 3 1 1 4 4 4 0 Resistin PD40 PF07676.12 ETO29003.1 - 0.043 13.8 1.6 46 4.1 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO29004.1 - 4.1e-53 176.2 22.0 8.8e-10 39.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29004.1 - 2.4e-20 72.6 3.8 0.0013 19.0 0.0 5.6 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29004.1 - 1.3e-09 37.9 2.8 0.03 13.6 0.1 4.0 1 1 3 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO29004.1 - 1e-08 34.6 2.0 0.012 14.6 0.5 5.1 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO29004.1 - 3.4e-07 29.3 2.1 2 6.9 0.0 4.9 1 1 4 5 5 5 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO29004.1 - 4.2e-05 22.5 6.7 0.079 11.7 0.7 3.5 1 1 1 2 2 2 2 Nup133 N terminal like Nbas_N PF15492.6 ETO29004.1 - 0.00026 20.4 1.0 0.043 13.2 0.1 2.8 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Utp8 PF10395.9 ETO29004.1 - 0.00049 18.7 0.2 1.5 7.2 0.0 3.1 2 1 1 3 3 3 2 Utp8 family Cytochrom_D1 PF02239.16 ETO29004.1 - 0.00072 18.2 0.0 0.19 10.2 0.0 2.6 1 1 2 3 3 3 2 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO29004.1 - 0.0017 17.4 1.6 0.38 9.8 0.0 2.6 1 1 2 3 3 3 2 Coatomer WD associated region PQQ PF01011.21 ETO29004.1 - 0.0036 17.1 0.0 1.3 9.1 0.0 3.8 3 0 0 3 3 3 1 PQQ enzyme repeat NHL PF01436.21 ETO29004.1 - 0.072 13.2 1.9 27 5.1 0.0 3.9 4 0 0 4 4 4 0 NHL repeat PD40 PF07676.12 ETO29004.1 - 0.074 13.0 2.1 12 5.9 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF4221 PF13970.6 ETO29004.1 - 0.11 12.0 0.8 2 7.9 0.0 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4221) Pkinase PF00069.25 ETO29005.1 - 4.2e-70 236.1 0.0 5.3e-70 235.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29005.1 - 1e-41 143.0 0.0 1.3e-41 142.6 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO29005.1 - 3.4e-08 33.1 0.0 9.6e-08 31.7 0.0 1.7 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO29005.1 - 0.00032 20.7 0.0 0.00057 19.9 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO29005.1 - 0.0019 17.6 1.5 0.007 15.7 0.0 2.4 3 0 0 3 3 3 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3439 PF11921.8 ETO29005.1 - 0.88 9.6 11.6 0.28 11.1 8.8 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Dicty_REP PF05086.12 ETO29005.1 - 1 7.3 11.4 1.4 6.8 11.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein SSP160 PF06933.11 ETO29005.1 - 2.1 6.5 13.5 3 5.9 13.5 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO29005.1 - 2.9 7.9 18.9 4.6 7.2 18.9 1.2 1 0 0 1 1 1 0 Mucin-like glycoprotein TMEM154 PF15102.6 ETO29005.1 - 9.7 6.1 11.1 16 5.4 11.1 1.3 1 0 0 1 1 1 0 TMEM154 protein family Pkinase PF00069.25 ETO29006.1 - 1.6e-50 171.9 0.0 2e-50 171.6 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29006.1 - 2e-31 109.2 0.0 2.3e-31 109.0 0.0 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO29006.1 - 2.3e-05 23.9 0.0 3.7e-05 23.2 0.0 1.3 1 1 0 1 1 1 1 Kinase-like APH PF01636.23 ETO29006.1 - 0.00012 22.0 0.0 0.0002 21.3 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO29006.1 - 0.0022 17.4 0.0 0.0022 17.4 0.0 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO29006.1 - 0.054 12.3 0.0 0.09 11.5 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Seadorna_VP7 PF07387.11 ETO29006.1 - 0.096 11.7 0.0 0.17 10.9 0.0 1.4 1 0 0 1 1 1 0 Seadornavirus VP7 Haspin_kinase PF12330.8 ETO29006.1 - 0.11 11.4 0.1 0.13 11.1 0.1 1.1 1 0 0 1 1 1 0 Haspin like kinase domain RIO1 PF01163.22 ETO29006.1 - 0.11 12.0 0.1 0.47 10.0 0.1 1.8 1 1 0 1 1 1 0 RIO1 family Pkinase PF00069.25 ETO29007.1 - 2.7e-05 23.7 0.0 4.1e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Activator_LAG-3 PF11498.8 ETO29007.1 - 0.042 12.8 0.2 0.053 12.5 0.2 1.2 1 0 0 1 1 1 0 Transcriptional activator LAG-3 Metallophos_C PF14008.6 ETO29008.1 - 6.3e-07 30.2 6.7 1.8e-05 25.5 4.6 3.0 2 1 0 2 2 2 1 Iron/zinc purple acid phosphatase-like protein C Metallophos PF00149.28 ETO29008.1 - 6.8e-05 23.5 0.2 0.00022 21.8 0.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Pur_ac_phosph_N PF16656.5 ETO29009.1 - 4.2e-10 40.1 1.8 3.2e-09 37.2 1.8 2.3 1 1 0 1 1 1 1 Purple acid Phosphatase, N-terminal domain PhoD_N PF16655.5 ETO29009.1 - 0.083 13.4 0.1 0.18 12.4 0.1 1.5 1 0 0 1 1 1 0 PhoD-like phosphatase, N-terminal domain Methyltr_RsmB-F PF01189.17 ETO29010.1 - 7.9e-64 215.0 0.0 2.9e-63 213.2 0.0 2.0 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Methyltr_RsmF_N PF17125.5 ETO29010.1 - 6e-09 36.3 0.0 1.7e-08 34.8 0.0 1.8 1 0 0 1 1 1 1 N-terminal domain of 16S rRNA methyltransferase RsmF FtsJ PF01728.19 ETO29010.1 - 0.0011 19.1 0.0 0.0024 18.0 0.0 1.5 1 0 0 1 1 1 1 FtsJ-like methyltransferase PCMT PF01135.19 ETO29010.1 - 0.0032 17.3 0.0 0.042 13.6 0.0 2.3 2 0 0 2 2 2 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Abhydrolase_3 PF07859.13 ETO29010.1 - 0.011 15.6 0.0 0.026 14.4 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S15 PF02129.18 ETO29010.1 - 0.035 13.7 0.0 0.035 13.7 0.0 2.2 3 0 0 3 3 3 0 X-Pro dipeptidyl-peptidase (S15 family) Abhydrolase_1 PF00561.20 ETO29010.1 - 0.17 11.5 0.1 11 5.5 0.0 2.9 2 1 0 3 3 3 0 alpha/beta hydrolase fold 2-Hacid_dh_C PF02826.19 ETO29011.1 - 5.7e-41 139.8 0.1 8.6e-41 139.2 0.1 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETO29011.1 - 1.1e-23 83.3 0.3 1.7e-23 82.8 0.3 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ETO29011.1 - 1.6e-08 34.9 0.1 3.3e-08 33.8 0.1 1.5 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase MFS_1 PF07690.16 ETO29012.1 - 1.5e-11 43.8 17.8 2.5e-10 39.8 7.2 2.1 1 1 1 2 2 2 2 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO29012.1 - 0.00014 20.8 6.0 0.00019 20.4 6.0 1.2 1 0 0 1 1 1 1 Sugar (and other) transporter STAT_alpha PF01017.20 ETO29014.1 - 0.11 12.4 5.4 0.049 13.5 1.8 1.9 2 0 0 2 2 2 0 STAT protein, all-alpha domain Erf4 PF10256.9 ETO29014.1 - 0.12 12.5 2.3 0.17 12.0 1.0 1.9 1 1 0 1 1 1 0 Golgin subfamily A member 7/ERF4 family DUF1765 PF08578.10 ETO29015.1 - 3.8e-11 43.5 3.5 3.8e-11 43.5 3.5 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF1765) Corona_M PF01635.18 ETO29015.1 - 0.019 14.3 0.0 0.035 13.4 0.0 1.4 1 0 0 1 1 1 0 Coronavirus M matrix/glycoprotein ABC2_membrane PF01061.24 ETO29016.1 - 3.2e-43 147.6 26.5 4.2e-43 147.2 26.5 1.2 1 0 0 1 1 1 1 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO29016.1 - 3.7e-08 32.9 18.9 3.7e-08 32.9 18.9 1.7 1 1 1 2 2 2 1 ABC-2 family transporter protein ABC2_membrane_2 PF12679.7 ETO29016.1 - 0.12 11.7 16.2 0.14 11.4 12.3 2.2 1 1 1 2 2 2 0 ABC-2 family transporter protein PH PF00169.29 ETO29017.1 - 3.6e-09 37.1 5.1 4.2e-08 33.6 5.1 2.3 1 1 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO29017.1 - 2.3e-08 34.1 9.7 2.5e-08 33.9 2.8 2.9 2 1 1 3 3 3 2 PH domain PH_8 PF15409.6 ETO29017.1 - 0.062 13.6 3.4 0.35 11.2 0.3 2.4 1 1 1 2 2 2 0 Pleckstrin homology domain Vps53_N PF04100.12 ETO29018.1 - 0.003 16.6 2.7 0.02 13.9 2.7 1.9 1 1 0 1 1 1 1 Vps53-like, N-terminal Sec6 PF06046.13 ETO29019.1 - 0.00084 17.8 0.3 0.0014 17.1 0.3 1.3 1 0 0 1 1 1 1 Exocyst complex component Sec6 Ion_trans PF00520.31 ETO29020.1 - 8.1e-25 87.5 48.8 1.4e-13 50.6 17.2 3.2 2 1 0 2 2 2 2 Ion transport protein cNMP_binding PF00027.29 ETO29020.1 - 4.5e-10 39.5 0.0 0.00015 21.8 0.0 2.5 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain DEP PF00610.21 ETO29020.1 - 0.00011 22.2 0.0 0.00031 20.8 0.0 1.7 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) EF-hand_8 PF13833.6 ETO29020.1 - 0.0012 18.6 0.3 0.076 12.9 0.0 3.3 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_7 PF13499.6 ETO29020.1 - 0.004 17.6 0.0 0.024 15.1 0.0 2.4 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO29020.1 - 0.028 14.0 0.0 0.22 11.2 0.0 2.7 2 0 0 2 2 2 0 EF hand Peptidase_M16_C PF05193.21 ETO29022.1 - 0.00032 20.7 0.0 0.00092 19.3 0.0 1.8 2 0 0 2 2 2 1 Peptidase M16 inactive domain DUF3908 PF13048.6 ETO29022.1 - 0.019 15.2 0.2 0.028 14.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3908) Peptidase_M16_M PF16187.5 ETO29023.1 - 1.6e-14 53.9 1.1 3.3e-14 52.9 1.1 1.5 1 0 0 1 1 1 1 Middle or third domain of peptidase_M16 CCB1 PF12046.8 ETO29023.1 - 0.082 12.2 0.1 0.13 11.6 0.1 1.4 1 0 0 1 1 1 0 Cofactor assembly of complex C subunit B PHO4 PF01384.20 ETO29024.1 - 2 7.4 4.8 3.9 6.4 4.7 1.5 1 1 0 1 1 1 0 Phosphate transporter family Hydrolase_4 PF12146.8 ETO29025.1 - 2.7e-11 43.2 0.0 7.1e-06 25.5 0.0 2.3 1 1 1 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO29025.1 - 2e-06 27.7 0.1 0.0034 17.1 0.0 2.3 1 1 1 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ETO29025.1 - 6.1e-05 22.9 0.3 0.0044 16.8 0.0 2.8 2 1 1 3 3 3 1 Phospholipase/Carboxylesterase Abhydrolase_3 PF07859.13 ETO29025.1 - 0.00013 21.9 0.0 0.00024 21.0 0.0 1.4 1 0 0 1 1 1 1 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETO29025.1 - 0.00019 21.0 0.0 0.00043 19.8 0.0 1.6 1 0 0 1 1 1 1 Prolyl oligopeptidase family DLH PF01738.18 ETO29025.1 - 0.0058 16.2 0.0 0.029 13.9 0.0 2.0 1 1 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_5 PF12695.7 ETO29025.1 - 0.015 15.1 0.0 0.056 13.2 0.0 1.9 1 1 1 2 2 2 0 Alpha/beta hydrolase family Abhydrolase_6 PF12697.7 ETO29025.1 - 0.046 14.3 0.0 0.086 13.4 0.0 1.5 1 1 0 1 1 1 0 Alpha/beta hydrolase family BAAT_C PF08840.11 ETO29025.1 - 0.069 13.1 0.0 2.6 7.9 0.0 2.6 1 1 0 1 1 1 0 BAAT / Acyl-CoA thioester hydrolase C terminal FSH1 PF03959.13 ETO29025.1 - 0.072 12.7 0.1 0.37 10.4 0.0 2.2 2 1 0 2 2 2 0 Serine hydrolase (FSH1) CD34_antigen PF06365.12 ETO29025.1 - 0.12 11.9 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF1749 PF08538.10 ETO29025.1 - 0.12 11.4 0.0 3.4 6.7 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1749) GWT1 PF06423.12 ETO29025.1 - 0.33 11.1 3.9 1.4 9.0 0.6 3.2 1 1 1 2 2 2 0 GWT1 Cadherin_C_2 PF16492.5 ETO29025.1 - 0.49 11.2 2.9 0.45 11.3 0.4 2.2 3 0 0 3 3 1 0 Cadherin cytoplasmic C-terminal DUF3671 PF12420.8 ETO29025.1 - 3.7 7.6 8.9 0.81 9.8 1.8 3.2 2 1 1 3 3 3 0 Protein of unknown function DUF4829 PF16111.5 ETO29026.1 - 0.0092 16.8 0.2 0.012 16.4 0.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4829) Me-amine-dh_H PF06433.11 ETO29026.1 - 0.039 12.8 0.1 0.04 12.8 0.1 1.1 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) DUF1279 PF06916.13 ETO29026.1 - 0.057 14.0 0.3 0.081 13.5 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) DUF5313 PF17240.2 ETO29026.1 - 0.085 13.3 0.0 0.72 10.3 0.0 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5313) Mpp10 PF04006.12 ETO29027.1 - 0.22 9.9 10.7 0.27 9.6 10.7 1.1 1 0 0 1 1 1 0 Mpp10 protein Menin PF05053.13 ETO29027.1 - 0.57 8.5 13.6 0.63 8.3 13.6 1.1 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO29027.1 - 3.2 6.5 8.8 3.9 6.2 8.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO29027.1 - 4.4 6.0 10.2 5.1 5.8 10.2 1.1 1 0 0 1 1 1 0 Presenilin AhpC-TSA PF00578.21 ETO29029.1 - 6e-20 71.4 0.0 2.2e-15 56.7 0.0 2.2 2 0 0 2 2 2 2 AhpC/TSA family Redoxin PF08534.10 ETO29029.1 - 1.1e-06 28.5 0.0 5.3e-06 26.2 0.0 1.9 1 1 0 1 1 1 1 Redoxin PUF PF00806.19 ETO29030.1 - 5.3e-21 73.1 8.6 5.9e-06 25.7 0.1 7.1 7 0 0 7 7 7 4 Pumilio-family RNA binding repeat LPD18 PF18832.1 ETO29030.1 - 0.061 13.4 1.2 1.7 8.8 0.3 2.7 1 1 1 2 2 2 0 Large polyvalent protein-associated domain 18 Macoilin PF09726.9 ETO29030.1 - 3.1 6.2 19.4 3.3 6.1 19.4 1.1 1 0 0 1 1 1 0 Macoilin family FHA PF00498.26 ETO29031.1 - 3.8e-12 46.4 0.2 5.7e-12 45.8 0.2 1.3 1 0 0 1 1 1 1 FHA domain FHA_2 PF17913.1 ETO29031.1 - 0.13 12.5 0.0 0.23 11.7 0.0 1.4 1 0 0 1 1 1 0 FHA domain HD_6 PF18019.1 ETO29032.1 - 0.0084 16.2 2.5 0.015 15.4 2.5 1.5 1 0 0 1 1 1 1 HD domain AAR2 PF05282.11 ETO29032.1 - 0.51 9.7 16.1 0.031 13.7 10.5 1.6 1 1 1 2 2 2 0 AAR2 protein SDA1 PF05285.12 ETO29032.1 - 2.9 7.2 27.6 4.6 6.6 27.6 1.2 1 0 0 1 1 1 0 SDA1 Ferlin_C PF16165.5 ETO29032.1 - 3.3 7.6 6.5 1.1 9.3 3.1 1.9 1 1 0 2 2 2 0 Ferlin C-terminus ETRAMP PF09716.10 ETO29033.1 - 0.42 10.7 7.7 1 9.5 7.7 1.6 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF3435 PF11917.8 ETO29033.1 - 4.1 6.2 7.4 15 4.3 7.5 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3435) SOCS PF12610.8 ETO29034.1 - 0.084 13.3 0.0 0.19 12.2 0.0 1.6 1 0 0 1 1 1 0 Suppressor of cytokine signalling NESP55 PF06390.12 ETO29034.1 - 0.091 12.4 0.0 0.15 11.6 0.0 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Secretin_N_2 PF07655.13 ETO29035.1 - 6.6 7.3 24.0 2.3 8.8 11.3 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Pneumo_att_G PF05539.11 ETO29037.1 - 0.43 10.1 9.5 0.55 9.8 9.5 1.1 1 0 0 1 1 1 0 Pneumovirinae attachment membrane glycoprotein G PPP4R2 PF09184.11 ETO29037.1 - 2.3 7.7 12.6 2.9 7.4 12.6 1.1 1 0 0 1 1 1 0 PPP4R2 Macoilin PF09726.9 ETO29037.1 - 4 5.9 11.6 4.5 5.7 11.6 1.0 1 0 0 1 1 1 0 Macoilin family Tim17 PF02466.19 ETO29038.1 - 1.1e-21 77.3 8.8 1.8e-21 76.6 8.8 1.3 1 0 0 1 1 1 1 Tim17/Tim22/Tim23/Pmp24 family 7tm_3 PF00003.22 ETO29040.1 - 7.1e-20 71.7 28.5 7.1e-20 71.7 28.5 2.4 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR adh_short PF00106.25 ETO29041.1 - 6.2e-42 143.3 0.2 2.2e-31 108.9 0.0 2.1 1 1 1 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO29041.1 - 1.9e-37 129.1 0.1 9.8e-28 97.3 0.0 3.0 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO29041.1 - 3.8e-10 39.9 0.0 1.3e-09 38.2 0.0 1.7 1 1 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ETO29041.1 - 0.072 13.0 0.3 0.31 10.9 0.4 2.0 1 1 1 2 2 2 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Epimerase PF01370.21 ETO29041.1 - 0.074 12.5 0.4 0.24 10.8 0.2 2.1 2 2 1 3 3 3 0 NAD dependent epimerase/dehydratase family FSA_C PF10479.9 ETO29042.1 - 3.7 5.6 10.5 5 5.1 10.5 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pkinase PF00069.25 ETO29045.1 - 2e-65 220.8 1.5 7.5e-50 169.7 1.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29045.1 - 2.2e-38 132.0 0.4 4.8e-30 104.7 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO29045.1 - 2.6e-06 27.0 2.0 0.00052 19.4 1.8 2.7 1 1 1 2 2 2 1 Kinase-like Pkinase_fungal PF17667.1 ETO29045.1 - 6.4e-06 25.2 0.2 8.6e-06 24.8 0.2 1.3 1 0 0 1 1 1 1 Fungal protein kinase Haspin_kinase PF12330.8 ETO29045.1 - 3e-05 23.1 5.4 0.00014 20.9 4.8 1.9 1 1 0 1 1 1 1 Haspin like kinase domain Kdo PF06293.14 ETO29045.1 - 0.0038 16.6 1.8 0.0096 15.3 1.8 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO29045.1 - 0.022 14.7 0.4 0.057 13.3 0.2 1.5 1 1 0 1 1 1 0 Phosphotransferase enzyme family Secretin_N_2 PF07655.13 ETO29045.1 - 0.87 10.2 9.4 0.49 11.0 7.3 1.6 2 0 0 2 2 2 0 Secretin N-terminal domain DnaJ PF00226.31 ETO29046.1 - 2.7e-16 59.4 0.9 6.8e-16 58.1 0.9 1.7 1 0 0 1 1 1 1 DnaJ domain Vma12 PF11712.8 ETO29046.1 - 0.023 14.8 0.0 0.043 13.9 0.0 1.4 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF5408 PF17402.2 ETO29047.1 - 0.11 12.4 1.8 4.6 7.2 0.4 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5408) T2SSE PF00437.20 ETO29048.1 - 0.073 12.1 0.3 0.1 11.6 0.3 1.1 1 0 0 1 1 1 0 Type II/IV secretion system protein Kelch_1 PF01344.25 ETO29049.1 - 9.6e-06 25.1 0.8 0.00024 20.6 0.7 3.0 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO29049.1 - 1.1e-05 25.5 3.4 8.3e-05 22.7 0.3 3.5 3 1 1 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO29049.1 - 0.00013 21.9 0.4 0.00064 19.7 0.1 2.3 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO29049.1 - 0.00013 22.1 0.1 0.00048 20.4 0.1 2.0 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29049.1 - 0.00016 21.5 2.7 0.00075 19.4 0.3 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO29049.1 - 0.0021 18.0 1.3 0.011 15.7 1.3 2.2 2 0 0 2 2 2 1 Kelch motif EF-1_beta_acid PF10587.9 ETO29050.1 - 6.3 7.3 8.1 3.8 8.0 4.3 2.4 2 0 0 2 2 2 0 Eukaryotic elongation factor 1 beta central acidic region WD40 PF00400.32 ETO29051.1 - 1.5e-86 282.0 54.3 2.1e-08 34.6 1.4 14.6 14 0 0 14 14 14 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29051.1 - 3.2e-21 75.4 13.2 0.0015 18.8 0.1 10.9 2 2 11 13 13 13 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29051.1 - 9.9e-14 51.0 5.9 0.046 12.7 0.0 8.2 3 2 3 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO29051.1 - 4.7e-10 39.6 0.0 1.6e-09 37.9 0.0 2.0 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO29051.1 - 1.2e-05 24.8 5.8 2.9e-05 23.6 5.8 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_22 PF13401.6 ETO29051.1 - 7.7e-05 23.0 0.2 0.00062 20.0 0.0 2.7 3 0 0 3 3 3 1 AAA domain Pentapeptide_4 PF13599.6 ETO29051.1 - 0.00021 21.4 1.7 0.001 19.2 1.7 2.2 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Str_synth PF03088.16 ETO29051.1 - 0.00087 19.4 0.6 0.8 9.9 0.0 4.5 5 1 1 6 6 5 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO29051.1 - 0.0034 16.0 10.2 0.51 8.8 0.0 5.1 5 1 0 6 6 6 2 Cytochrome D1 heme domain Pentapeptide_3 PF13576.6 ETO29051.1 - 0.0067 16.6 1.1 0.024 14.8 1.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO29051.1 - 0.018 15.1 12.2 11 6.1 0.0 6.2 5 1 2 7 7 7 0 Family of unknown function (DUF5570) AAA_18 PF13238.6 ETO29051.1 - 0.067 13.7 0.0 0.55 10.8 0.0 2.7 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO29051.1 - 0.11 12.8 0.0 0.48 10.8 0.0 2.1 1 0 0 1 1 1 0 AAA ATPase domain CUE PF02845.16 ETO29051.1 - 0.12 12.1 0.1 0.12 12.1 0.1 2.5 3 0 0 3 3 3 0 CUE domain TFIIS_M PF07500.14 ETO29051.1 - 0.46 11.0 0.0 0.46 11.0 0.0 3.7 5 0 0 5 5 4 0 Transcription factor S-II (TFIIS), central domain SMC_N PF02463.19 ETO29051.1 - 0.84 9.0 3.9 7.3 5.9 0.0 3.3 3 0 0 3 3 3 0 RecF/RecN/SMC N terminal domain Proteasome_A_N PF10584.9 ETO29051.1 - 2.1 8.1 6.8 1.5e+02 2.2 0.1 5.6 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature RsgA_GTPase PF03193.16 ETO29051.1 - 2.3 8.1 0.0 2.3 8.1 0.0 3.3 4 0 0 4 4 4 0 RsgA GTPase WD40 PF00400.32 ETO29052.1 - 3.9e-35 119.3 13.4 2.6e-07 31.2 0.1 7.4 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29052.1 - 1.2e-18 67.1 0.3 0.0035 17.6 0.0 5.6 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29052.1 - 5.2e-11 42.4 0.4 0.01 15.2 0.0 3.2 3 0 0 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO29052.1 - 1.5e-10 40.5 1.5 1.2 8.1 0.0 6.7 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO29052.1 - 2.2e-09 37.5 0.0 0.0094 15.9 0.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO29052.1 - 6.6e-06 25.9 0.5 0.37 10.8 0.0 5.4 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO29052.1 - 0.0046 15.5 0.2 0.2 10.1 0.1 2.4 1 1 0 2 2 2 1 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO29052.1 - 0.052 13.6 0.1 53 3.9 0.0 3.5 2 2 1 3 3 3 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO29052.1 - 1.3 8.7 5.8 4.1 7.2 0.1 3.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature APG6_N PF17675.1 ETO29053.1 - 0.00078 20.0 10.6 0.001 19.6 10.6 1.3 1 0 0 1 1 1 1 Apg6 coiled-coil region FTA4 PF13093.6 ETO29053.1 - 0.0011 18.9 6.8 0.0014 18.6 6.8 1.2 1 0 0 1 1 1 1 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 MCU PF04678.13 ETO29053.1 - 0.0013 18.8 0.8 0.0015 18.7 0.8 1.2 1 0 0 1 1 1 1 Mitochondrial calcium uniporter Pro_CA PF00484.19 ETO29053.1 - 0.0036 17.6 4.2 0.0055 17.0 4.2 1.3 1 0 0 1 1 1 1 Carbonic anhydrase KELK PF15796.5 ETO29053.1 - 0.0063 16.9 4.5 0.0063 16.9 4.5 1.9 2 0 0 2 2 1 1 KELK-motif containing domain of MRCK Ser/Thr protein kinase DUF812 PF05667.11 ETO29053.1 - 0.0067 15.4 10.8 0.0077 15.2 10.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF812) DUF3450 PF11932.8 ETO29053.1 - 0.007 15.7 8.1 0.0089 15.4 8.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) Cluap1 PF10234.9 ETO29053.1 - 0.0081 15.6 8.7 0.0097 15.3 8.7 1.2 1 0 0 1 1 1 1 Clusterin-associated protein-1 FlxA PF14282.6 ETO29053.1 - 0.01 15.8 13.5 0.01 15.8 13.5 1.8 2 0 0 2 2 2 0 FlxA-like protein Nup54 PF13874.6 ETO29053.1 - 0.013 15.6 6.8 0.018 15.2 6.8 1.2 1 0 0 1 1 1 0 Nucleoporin complex subunit 54 SKA2 PF16740.5 ETO29053.1 - 0.02 14.7 6.3 0.03 14.1 6.3 1.3 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 2 HALZ PF02183.18 ETO29053.1 - 0.022 15.0 0.6 0.022 15.0 0.6 1.9 2 0 0 2 2 1 0 Homeobox associated leucine zipper TMPIT PF07851.13 ETO29053.1 - 0.024 13.9 6.4 0.029 13.6 6.4 1.1 1 0 0 1 1 1 0 TMPIT-like protein Spc7 PF08317.11 ETO29053.1 - 0.028 13.3 10.9 0.013 14.4 8.7 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein FapA PF03961.13 ETO29053.1 - 0.047 12.3 5.5 0.055 12.1 5.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF3375 PF11855.8 ETO29053.1 - 0.052 12.5 1.4 0.071 12.0 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) AAA_11 PF13086.6 ETO29053.1 - 0.08 12.7 6.7 0.1 12.4 6.7 1.2 1 0 0 1 1 1 0 AAA domain DUF4509 PF14970.6 ETO29053.1 - 0.1 12.5 7.1 0.12 12.3 7.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) V_ATPase_I PF01496.19 ETO29053.1 - 0.14 10.0 10.1 0.15 10.0 10.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Cupin_8 PF13621.6 ETO29053.1 - 0.15 11.8 8.4 0.17 11.6 8.4 1.1 1 0 0 1 1 1 0 Cupin-like domain DUF4763 PF15960.5 ETO29053.1 - 0.15 11.3 15.1 0.14 11.4 13.8 1.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4763) Sigma70_ner PF04546.13 ETO29053.1 - 0.2 11.5 10.0 0.26 11.1 10.0 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region PDDEXK_6 PF04720.12 ETO29053.1 - 0.24 11.3 7.2 0.34 10.8 7.2 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function CDC45 PF02724.14 ETO29053.1 - 0.76 8.0 12.9 0.83 7.9 12.9 1.0 1 0 0 1 1 1 0 CDC45-like protein T2SSM PF04612.12 ETO29053.1 - 0.93 9.5 5.5 1.8 8.6 5.5 1.4 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein M YabA PF06156.13 ETO29053.1 - 3.3 8.4 14.2 2.1 9.0 12.2 1.8 1 1 0 1 1 1 0 Initiation control protein YabA DUF4407 PF14362.6 ETO29053.1 - 4.9 6.4 8.7 2 7.7 6.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) UPF0242 PF06785.11 ETO29053.1 - 9 6.4 19.3 15 5.6 19.3 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus zf-H2C2_2 PF13465.6 ETO29054.1 - 1.5e-07 31.5 17.6 4e-05 23.8 2.0 3.9 3 0 0 3 3 3 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETO29054.1 - 0.0029 18.0 5.7 0.0029 18.0 5.7 3.5 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO29054.1 - 0.015 16.1 3.8 0.015 16.1 3.8 3.8 3 0 0 3 3 3 0 C2H2-type zinc finger HI0933_like PF03486.14 ETO29055.1 - 0.0063 15.3 5.5 0.0086 14.8 5.5 1.1 1 0 0 1 1 1 1 HI0933-like protein PmbA_TldD PF01523.16 ETO29055.1 - 0.025 14.4 0.4 0.033 14.1 0.4 1.1 1 0 0 1 1 1 0 Putative modulator of DNA gyrase DUF4410 PF14366.6 ETO29055.1 - 0.18 11.7 3.2 0.16 11.9 1.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4410) AAA_11 PF13086.6 ETO29055.1 - 0.35 10.6 7.1 0.47 10.2 7.1 1.1 1 0 0 1 1 1 0 AAA domain FapA PF03961.13 ETO29055.1 - 0.49 8.9 11.4 0.59 8.7 11.4 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A SMAP PF15477.6 ETO29055.1 - 2.3 9.2 9.3 2.6 9.1 7.6 1.8 1 1 1 2 2 2 0 Small acidic protein family CorA PF01544.18 ETO29055.1 - 4 6.7 7.5 1.2 8.3 4.0 1.8 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Vps55 PF04133.14 ETO29056.1 - 0.042 13.8 2.0 0.92 9.5 0.1 2.5 2 1 0 2 2 2 0 Vacuolar protein sorting 55 CEBP_ZZ PF16366.5 ETO29057.1 - 0.43 10.8 11.4 1.1 9.5 11.4 1.7 1 0 0 1 1 1 0 Cytoplasmic polyadenylation element-binding protein ZZ domain zf-UBR PF02207.20 ETO29058.1 - 8.6e-18 64.3 14.4 1.1e-17 63.9 14.4 1.1 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) PH PF00169.29 ETO29059.1 - 8.7e-11 42.3 0.2 2.1e-10 41.0 0.1 1.7 1 1 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO29059.1 - 8.3e-06 26.2 0.1 8.3e-06 26.2 0.1 1.7 2 0 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ETO29059.1 - 0.00046 20.4 0.0 0.0011 19.2 0.0 1.7 1 0 0 1 1 1 1 Pleckstrin homology domain DUF3915 PF13054.6 ETO29059.1 - 0.028 14.4 1.4 0.043 13.8 1.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Atrophin-1 PF03154.15 ETO29059.1 - 0.43 8.8 10.1 0.069 11.4 5.6 1.7 2 0 0 2 2 2 0 Atrophin-1 family PH_4 PF15404.6 ETO29059.1 - 0.64 9.8 0.1 0.64 9.8 0.1 2.2 1 1 1 2 2 2 0 Pleckstrin homology domain PH PF00169.29 ETO29060.1 - 2.8e-28 98.5 10.9 1e-13 51.7 0.2 3.7 3 1 0 3 3 3 3 PH domain PH_11 PF15413.6 ETO29060.1 - 9.9e-09 35.6 17.9 0.00051 20.4 3.7 4.9 4 2 0 4 4 4 2 Pleckstrin homology domain PH_3 PF14593.6 ETO29060.1 - 6.6e-05 23.0 7.5 0.18 12.0 0.1 5.1 4 1 1 5 5 5 2 PH domain PH_8 PF15409.6 ETO29060.1 - 0.00015 22.0 13.2 0.16 12.3 0.5 4.6 4 2 0 4 4 4 3 Pleckstrin homology domain Mcp5_PH PF12814.7 ETO29060.1 - 0.0083 16.2 0.6 0.44 10.7 0.2 3.1 2 1 1 3 3 3 1 Meiotic cell cortex C-terminal pleckstrin homology PH_2 PF08458.10 ETO29060.1 - 0.019 15.3 0.6 10 6.5 0.0 2.9 3 0 0 3 3 3 0 Plant pleckstrin homology-like region DYW_deaminase PF14432.6 ETO29060.1 - 0.028 14.3 0.0 0.068 13.0 0.0 1.7 1 0 0 1 1 1 0 DYW family of nucleic acid deaminases TRAM_LAG1_CLN8 PF03798.16 ETO29061.1 - 3.7e-29 101.9 23.8 6.6e-29 101.1 23.8 1.3 1 0 0 1 1 1 1 TLC domain DUF1635 PF07795.11 ETO29061.1 - 0.067 13.0 2.2 0.12 12.2 2.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1635) Mlh1_C PF16413.5 ETO29061.1 - 4 6.7 9.7 0.053 12.9 1.6 1.9 2 0 0 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus CRAL_TRIO PF00650.20 ETO29062.1 - 6.5e-14 51.9 0.9 1.2e-13 51.1 0.3 1.8 2 0 0 2 2 2 1 CRAL/TRIO domain Secretin_N_2 PF07655.13 ETO29062.1 - 9.2 6.9 11.8 1.7 9.3 5.6 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain ubiquitin PF00240.23 ETO29063.1 - 1.3e-13 50.5 0.4 1.3e-12 47.3 0.1 2.3 1 1 1 2 2 2 1 Ubiquitin family C2 PF00168.30 ETO29063.1 - 2.1e-08 34.3 0.2 0.00011 22.4 0.0 3.3 3 0 0 3 3 3 2 C2 domain Rad60-SLD PF11976.8 ETO29063.1 - 5.1e-08 32.6 0.2 2.1e-07 30.7 0.2 2.1 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like DUF2407 PF10302.9 ETO29063.1 - 5.8e-07 30.0 0.4 1.8e-06 28.4 0.4 1.8 1 0 0 1 1 1 1 DUF2407 ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO29063.1 - 0.0067 16.5 1.5 0.0067 16.5 1.5 3.2 3 1 0 3 3 3 1 Ubiquitin-like domain TBK1_ULD PF18396.1 ETO29063.1 - 0.01 15.7 0.0 0.021 14.7 0.0 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_5 PF18037.1 ETO29063.1 - 0.075 13.4 1.8 3 8.2 0.1 3.1 4 0 0 4 4 4 0 Ubiquitin-like domain V-set PF07686.17 ETO29063.1 - 1.1 9.5 5.6 1 9.6 0.1 2.7 2 1 1 3 3 3 0 Immunoglobulin V-set domain Beach PF02138.18 ETO29065.1 - 1.6e-33 116.3 1.4 3.9e-32 111.7 0.1 2.4 2 1 0 2 2 2 2 Beige/BEACH domain PH_BEACH PF14844.6 ETO29065.1 - 9.1e-05 22.5 7.0 0.00011 22.2 0.8 3.2 3 1 0 3 3 3 1 PH domain associated with Beige/BEACH Beach PF02138.18 ETO29066.1 - 3.5e-72 243.1 0.1 4.6e-72 242.7 0.1 1.0 1 0 0 1 1 1 1 Beige/BEACH domain Homeobox_KN PF05920.11 ETO29067.1 - 2.1e-12 46.7 1.2 3.6e-12 46.0 1.2 1.4 1 0 0 1 1 1 1 Homeobox KN domain Homeodomain PF00046.29 ETO29067.1 - 1.1e-08 34.8 0.3 2.7e-08 33.5 0.2 1.7 1 1 1 2 2 2 1 Homeodomain Plasmodium_Vir PF05795.11 ETO29068.1 - 0.87 8.9 6.5 1.5 8.2 6.5 1.4 1 1 0 1 1 1 0 Plasmodium vivax Vir protein eIF-3_zeta PF05091.12 ETO29068.1 - 1.1 8.2 7.6 1.2 8.0 7.6 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) baeRF_family12 PF18856.1 ETO29068.1 - 5 7.7 9.3 5.9 7.5 8.4 1.5 1 1 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 12 DUF1179 PF06678.11 ETO29068.1 - 8.8 6.4 11.0 8.6 6.4 2.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1179) DUF3439 PF11921.8 ETO29068.1 - 9 6.3 18.7 0.45 10.5 10.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) Citrate_synt PF00285.21 ETO29069.1 - 1e-51 176.1 0.0 1.2e-51 175.9 0.0 1.0 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain GFRP PF06399.13 ETO29069.1 - 0.036 13.9 0.0 0.061 13.2 0.0 1.3 1 0 0 1 1 1 0 GTP cyclohydrolase I feedback regulatory protein (GFRP) RRM_1 PF00076.22 ETO29071.1 - 7.3e-16 57.8 0.4 2.2e-06 27.4 0.1 3.1 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF1866 PF08952.11 ETO29071.1 - 0.012 15.4 0.0 0.033 14.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1866) RRM_3 PF08777.11 ETO29071.1 - 0.043 13.9 0.1 0.11 12.5 0.1 1.7 1 0 0 1 1 1 0 RNA binding motif Oxidored-like PF09791.9 ETO29073.1 - 6.4e-10 38.5 4.4 1.4e-09 37.4 4.4 1.6 1 0 0 1 1 1 1 Oxidoreductase-like protein, N-terminal Neur_chan_memb PF02932.16 ETO29074.1 - 0.039 14.0 1.7 0.051 13.6 1.7 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAP1 PF08601.10 ETO29074.1 - 0.054 13.2 12.5 0.061 13.0 12.5 1.2 1 0 0 1 1 1 0 Transcription factor PAP1 HemY_N PF07219.13 ETO29074.1 - 0.16 12.2 0.2 0.32 11.2 0.2 1.6 1 0 0 1 1 1 0 HemY protein N-terminus SID-1_RNA_chan PF13965.6 ETO29074.1 - 0.19 10.1 0.5 0.26 9.7 0.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF1180 PF06679.12 ETO29074.1 - 4.5 7.7 9.0 13 6.1 9.0 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1180) WD40 PF00400.32 ETO29075.1 - 2.6e-50 167.3 15.6 6.6e-10 39.4 0.2 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29075.1 - 3.5e-12 46.4 0.2 0.44 10.9 0.0 5.5 2 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29075.1 - 5.9e-09 35.3 0.3 0.34 9.8 0.0 5.1 2 1 2 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO29075.1 - 0.00013 20.8 1.3 0.33 9.5 0.0 3.3 2 1 1 3 3 3 3 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETO29075.1 - 0.0093 15.6 1.5 21 4.9 0.0 4.0 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature PD40 PF07676.12 ETO29075.1 - 0.11 12.5 2.6 4.4 7.4 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat RNA_ligase PF09414.10 ETO29076.1 - 1.3e-05 25.6 0.0 1.9e-05 25.0 0.0 1.2 1 0 0 1 1 1 1 RNA ligase RNA_ligase PF09414.10 ETO29077.1 - 0.00026 21.3 1.0 0.0043 17.4 0.1 2.3 2 0 0 2 2 2 2 RNA ligase WD40 PF00400.32 ETO29078.1 - 1.7e-40 136.2 21.0 1.2e-06 29.2 0.0 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29078.1 - 5.2e-14 52.3 1.8 0.014 15.6 0.0 6.7 4 2 3 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29078.1 - 5.1e-08 32.0 7.0 0.068 11.8 0.0 5.7 4 2 1 6 6 6 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO29078.1 - 8.4e-08 32.8 2.5 5e-07 30.3 2.5 2.5 1 0 0 1 1 1 1 TRAF-type zinc finger DUF4239 PF14023.6 ETO29078.1 - 4.3 7.0 11.3 0.14 11.9 3.1 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4239) EF-hand_7 PF13499.6 ETO29079.1 - 5.4e-12 46.0 11.3 1.7e-07 31.6 0.9 2.6 1 1 2 3 3 3 3 EF-hand domain pair EF-hand_1 PF00036.32 ETO29079.1 - 5.1e-11 41.3 1.7 1.2e-05 24.5 0.5 2.7 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO29079.1 - 5.3e-10 39.0 1.1 6.9e-05 22.6 0.0 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO29079.1 - 9e-08 31.5 0.3 0.029 14.3 0.0 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_5 PF13202.6 ETO29079.1 - 5.9e-06 25.5 1.6 0.021 14.3 0.0 2.5 2 0 0 2 2 2 2 EF hand SPARC_Ca_bdg PF10591.9 ETO29079.1 - 0.0001 22.6 0.2 0.0002 21.6 0.2 1.5 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETO29079.1 - 0.0018 18.6 0.3 2.1 8.7 0.0 2.7 3 1 0 3 3 3 2 EF-hand domain EF-hand_4 PF12763.7 ETO29079.1 - 0.014 15.3 0.3 0.42 10.6 0.1 2.2 1 1 1 2 2 2 0 Cytoskeletal-regulatory complex EF hand CD36 PF01130.21 ETO29081.1 - 0.32 9.5 4.4 0.43 9.1 4.4 1.1 1 0 0 1 1 1 0 CD36 family Ac81 PF05820.11 ETO29081.1 - 6.6 6.3 8.2 9.3 5.8 8.2 1.3 1 0 0 1 1 1 0 Baculoviridae AC81 F-box_4 PF15966.5 ETO29082.1 - 0.031 14.2 0.4 0.28 11.1 0.1 2.2 1 1 0 2 2 2 0 F-box OKR_DC_1_N PF03709.15 ETO29082.1 - 0.097 13.0 0.0 0.23 11.8 0.0 1.7 1 0 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain DLP_helical PF18709.1 ETO29084.1 - 0.0072 15.6 3.7 0.2 10.8 0.2 2.1 2 0 0 2 2 2 2 Dynamin-like helical domain LOH1CR12 PF10158.9 ETO29084.1 - 0.012 15.6 1.9 0.013 15.5 0.5 1.7 2 0 0 2 2 2 0 Tumour suppressor protein Vps5 PF09325.10 ETO29084.1 - 0.014 15.0 6.6 0.022 14.3 6.6 1.3 1 0 0 1 1 1 0 Vps5 C terminal like DUF948 PF06103.11 ETO29084.1 - 0.014 15.7 4.3 0.014 15.7 4.3 2.3 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 ETO29084.1 - 0.031 14.3 3.7 0.061 13.3 3.7 1.5 1 0 0 1 1 1 0 Laminin Domain II Occludin_ELL PF07303.13 ETO29084.1 - 0.081 13.7 3.7 1.3 9.8 0.2 2.7 2 1 0 2 2 2 0 Occludin homology domain LPP PF04728.13 ETO29084.1 - 0.14 12.5 5.4 1.1 9.7 0.4 3.2 2 1 1 3 3 3 0 Lipoprotein leucine-zipper SKA2 PF16740.5 ETO29084.1 - 0.39 10.5 8.8 0.35 10.7 5.9 2.1 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 Tup_N PF08581.10 ETO29084.1 - 1.8 9.0 9.5 0.28 11.5 1.8 2.9 2 1 0 2 2 2 0 Tup N-terminal DASH_Dam1 PF08653.10 ETO29084.1 - 2.6 7.9 8.9 4.3 7.2 3.6 3.1 2 1 1 3 3 3 0 DASH complex subunit Dam1 DUF16 PF01519.16 ETO29084.1 - 6.9 7.2 10.7 0.61 10.6 1.2 3.0 2 1 1 3 3 3 0 Protein of unknown function DUF16 ATG7_N PF16420.5 ETO29085.1 - 6.2e-46 157.4 0.3 7.9e-46 157.1 0.3 1.2 1 0 0 1 1 1 1 Ubiquitin-like modifier-activating enzyme ATG7 N-terminus FAM176 PF14851.6 ETO29086.1 - 0.024 14.3 5.5 0.024 14.3 5.5 1.1 1 0 0 1 1 1 0 FAM176 family RAP1 PF07218.11 ETO29086.1 - 0.053 11.8 10.1 0.051 11.9 10.1 1.0 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) RNA12 PF10443.9 ETO29086.1 - 0.057 12.1 4.7 0.068 11.9 4.7 1.0 1 0 0 1 1 1 0 RNA12 protein Sporozoite_P67 PF05642.11 ETO29086.1 - 0.12 10.4 1.9 0.12 10.5 1.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4530 PF15039.6 ETO29086.1 - 0.19 11.9 6.4 0.27 11.4 6.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4530) AIF_C PF14721.6 ETO29086.1 - 0.26 11.6 3.2 0.32 11.4 3.2 1.1 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term CDC45 PF02724.14 ETO29086.1 - 0.45 8.7 6.9 0.47 8.7 6.9 1.0 1 0 0 1 1 1 0 CDC45-like protein LRIF1 PF15741.5 ETO29086.1 - 0.77 8.2 8.5 0.83 8.1 8.5 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Eapp_C PF10238.9 ETO29086.1 - 1.3 9.1 6.9 1.4 9.0 6.9 1.1 1 0 0 1 1 1 0 E2F-associated phosphoprotein Ferlin_C PF16165.5 ETO29086.1 - 1.7 8.6 9.2 1.8 8.5 9.2 1.2 1 0 0 1 1 1 0 Ferlin C-terminus PAC1 PF16094.5 ETO29086.1 - 2 7.5 6.2 2.4 7.3 6.2 1.1 1 0 0 1 1 1 0 Proteasome assembly chaperone 4 Connexin PF00029.19 ETO29086.1 - 2 8.1 7.5 2.1 8.0 7.5 1.0 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO29086.1 - 3.3 6.4 4.0 3.1 6.4 4.0 1.0 1 0 0 1 1 1 0 Presenilin DUF3682 PF12446.8 ETO29086.1 - 7.9 7.0 10.5 9.8 6.7 10.5 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) WD40 PF00400.32 ETO29088.1 - 8.6e-05 23.2 1.1 8.6e-05 23.2 1.1 2.0 2 1 0 2 2 2 1 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO29088.1 - 0.054 12.2 0.0 0.061 12.1 0.0 1.1 1 0 0 1 1 1 0 Nup133 N terminal like TPR_12 PF13424.6 ETO29089.1 - 5.4e-26 90.7 0.0 8.9e-15 54.7 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29089.1 - 2.4e-17 62.2 0.0 3.8e-06 26.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO29089.1 - 6.2e-13 47.9 5.4 0.0037 17.4 0.2 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29089.1 - 1.3e-11 43.7 0.0 0.026 14.5 0.0 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29089.1 - 3.2e-11 42.5 11.2 9.6e-05 22.0 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29089.1 - 3.5e-10 39.2 6.3 0.0057 16.7 0.2 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29089.1 - 1e-08 34.7 5.0 3.9e-05 23.2 0.2 3.3 2 1 0 2 2 2 2 TPR repeat SNAP PF14938.6 ETO29089.1 - 0.00035 20.1 0.0 0.00069 19.1 0.0 1.4 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO29089.1 - 0.00068 20.1 0.1 1.1 10.0 0.0 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat MIT PF04212.18 ETO29089.1 - 0.0023 17.9 2.1 0.043 13.9 0.3 3.2 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain NIBRIN_BRCT_II PF16508.5 ETO29089.1 - 0.02 15.2 0.3 0.042 14.2 0.3 1.5 1 0 0 1 1 1 0 Second BRCT domain on Nijmegen syndrome breakage protein TPR_17 PF13431.6 ETO29089.1 - 0.032 14.6 0.1 1.5 9.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO29089.1 - 0.061 14.2 0.0 14 6.9 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO29089.1 - 0.19 12.4 0.3 4.6 8.1 0.0 2.8 3 0 0 3 3 3 0 Sel1 repeat WD40 PF00400.32 ETO29091.1 - 8.4e-82 267.0 30.5 8.6e-09 35.9 0.3 12.4 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29091.1 - 6.5e-20 71.2 8.0 0.025 14.9 0.1 8.6 1 1 5 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29091.1 - 1.2e-13 51.1 7.3 6.4e-05 22.4 0.0 5.9 2 1 5 7 7 7 4 WD40-like domain NACHT PF05729.12 ETO29091.1 - 4.4e-11 43.0 0.0 9.4e-11 41.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 ETO29091.1 - 4.8e-10 38.9 1.9 0.022 13.8 0.1 7.4 1 1 7 9 9 9 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO29091.1 - 4.2e-07 29.5 2.1 9.2e-07 28.4 2.1 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO29091.1 - 0.00039 20.5 0.0 18 5.5 0.0 5.8 4 1 0 5 5 5 0 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO29091.1 - 0.00082 19.5 0.3 0.0023 18.1 0.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO29091.1 - 0.0011 19.3 0.0 0.012 15.9 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO29091.1 - 0.0028 18.2 0.0 0.016 15.8 0.0 2.5 1 0 0 1 1 1 1 AAA domain PD40 PF07676.12 ETO29091.1 - 0.0046 16.9 7.7 16 5.5 0.0 6.7 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO29091.1 - 0.02 15.0 0.5 0.055 13.6 0.5 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO29091.1 - 0.026 13.1 1.5 1.9 7.0 0.1 3.4 2 1 2 5 5 5 0 Cytochrome D1 heme domain Mid2 PF04478.12 ETO29091.1 - 0.034 14.0 1.2 11 5.9 0.0 4.1 4 1 1 5 5 5 0 Mid2 like cell wall stress sensor RNA_helicase PF00910.22 ETO29091.1 - 0.04 14.3 1.0 0.4 11.1 0.0 3.3 4 0 0 4 4 3 0 RNA helicase ABC_tran PF00005.27 ETO29091.1 - 0.058 13.9 0.4 0.3 11.6 0.0 2.5 2 0 0 2 2 2 0 ABC transporter AAA PF00004.29 ETO29091.1 - 0.066 13.6 0.0 0.22 11.9 0.0 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) OTOS PF15182.6 ETO29091.1 - 0.12 12.3 0.3 7.8 6.5 0.0 2.9 2 1 1 3 3 3 0 Otospiralin W_rich_C PF07483.11 ETO29091.1 - 0.55 10.4 6.0 5.6 7.2 0.4 3.9 2 1 0 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain WD40 PF00400.32 ETO29092.1 - 2.1e-36 123.3 6.5 2.5e-10 40.7 0.1 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29092.1 - 6e-12 45.7 0.3 0.014 15.7 0.1 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29092.1 - 5.3e-07 28.7 4.0 1.5 7.4 0.0 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO29092.1 - 1.7e-06 27.2 0.1 0.54 9.2 0.0 3.3 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO29092.1 - 8.3e-06 25.9 1.0 5.1 7.2 0.1 4.1 1 1 3 4 4 4 3 Family of unknown function (DUF5570) Str_synth PF03088.16 ETO29092.1 - 0.0025 17.9 0.1 6.7 6.9 0.0 3.4 2 2 1 3 3 3 1 Strictosidine synthase PD40 PF07676.12 ETO29092.1 - 0.0046 16.8 1.0 21 5.2 0.1 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ETO29092.1 - 0.0084 15.9 0.0 0.012 15.3 0.0 1.2 1 0 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain WD40_like PF17005.5 ETO29092.1 - 0.0084 15.5 0.1 1.6 8.0 0.1 2.3 1 1 2 3 3 3 3 WD40-like domain Nbas_N PF15492.6 ETO29092.1 - 0.013 14.9 0.9 3.3 6.9 0.0 3.0 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Sod_Cu PF00080.20 ETO29092.1 - 0.058 13.6 0.0 6.7 6.9 0.0 2.2 2 0 0 2 2 2 0 Copper/zinc superoxide dismutase (SODC) Microvir_J PF04726.13 ETO29092.1 - 0.15 12.1 0.3 55 3.8 0.1 3.7 5 0 0 5 5 5 0 Microvirus J protein cobW PF02492.19 ETO29093.1 - 2.8e-14 53.1 0.1 6.2e-14 52.0 0.1 1.6 1 0 0 1 1 1 1 CobW/HypB/UreG, nucleotide-binding domain TsaE PF02367.17 ETO29093.1 - 0.0072 16.3 0.1 0.012 15.6 0.1 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ATPase_2 PF01637.18 ETO29093.1 - 0.011 15.7 0.1 0.025 14.5 0.1 1.7 1 1 0 1 1 1 0 ATPase domain predominantly from Archaea MobB PF03205.14 ETO29093.1 - 0.019 14.9 0.2 0.047 13.6 0.2 1.7 1 0 0 1 1 1 0 Molybdopterin guanine dinucleotide synthesis protein B AAA_33 PF13671.6 ETO29093.1 - 0.06 13.5 0.1 0.06 13.5 0.1 2.9 4 0 0 4 4 4 0 AAA domain AAA_16 PF13191.6 ETO29093.1 - 0.12 12.7 0.5 0.22 11.9 0.0 1.6 2 0 0 2 2 2 0 AAA ATPase domain Viral_helicase1 PF01443.18 ETO29093.1 - 0.14 11.8 0.1 0.14 11.8 0.1 2.7 3 0 0 3 3 3 0 Viral (Superfamily 1) RNA helicase AAA_18 PF13238.6 ETO29093.1 - 1.1 9.8 0.1 1.1 9.8 0.1 2.7 3 0 0 3 3 3 0 AAA domain TFIIA PF03153.13 ETO29094.1 - 1.4e-06 28.6 17.3 1.4e-06 28.6 17.3 2.2 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit Eapp_C PF10238.9 ETO29094.1 - 0.00044 20.4 1.7 0.00044 20.4 1.7 3.4 2 1 0 2 2 1 1 E2F-associated phosphoprotein SpoIIP PF07454.11 ETO29094.1 - 0.00045 19.8 4.2 0.00045 19.8 4.2 2.9 3 0 0 3 3 3 1 Stage II sporulation protein P (SpoIIP) PAT1 PF09770.9 ETO29094.1 - 0.0017 16.7 13.3 0.0017 16.7 13.3 1.9 2 0 0 2 2 2 1 Topoisomerase II-associated protein PAT1 RPN2_C PF18004.1 ETO29094.1 - 0.0019 18.1 3.3 0.0019 18.1 3.3 3.8 4 0 0 4 4 3 1 26S proteasome regulatory subunit RPN2 C-terminal domain DDRGK PF09756.9 ETO29094.1 - 0.0028 17.3 8.7 0.0028 17.3 8.7 3.6 4 0 0 4 4 3 1 DDRGK domain DUF5308 PF17233.2 ETO29094.1 - 0.0028 17.9 0.7 0.0028 17.9 0.7 2.3 2 1 0 2 2 1 1 Family of unknown function (DUF5308) DUF2052 PF09747.9 ETO29094.1 - 0.003 17.7 3.6 0.003 17.7 3.6 2.7 2 1 0 2 2 2 1 Coiled-coil domain containing protein (DUF2052) DUF4770 PF15994.5 ETO29094.1 - 0.0052 17.0 6.5 0.0052 17.0 6.5 3.1 2 1 0 2 2 1 1 Domain of unknown function (DUF4770) DUF3395 PF11875.8 ETO29094.1 - 0.0053 16.6 3.3 0.0053 16.6 3.3 3.8 3 1 1 4 4 4 1 Domain of unknown function (DUF3395) Band_3_cyto PF07565.13 ETO29094.1 - 0.0058 16.5 3.3 0.0058 16.5 3.3 2.3 2 0 0 2 2 2 1 Band 3 cytoplasmic domain GramPos_pilinD1 PF16555.5 ETO29094.1 - 0.0079 16.4 1.0 0.0079 16.4 1.0 2.3 3 1 1 4 4 2 1 Gram-positive pilin subunit D1, N-terminal domain AAA_11 PF13086.6 ETO29094.1 - 0.0091 15.8 3.6 0.0091 15.8 3.6 2.6 3 0 0 3 3 3 1 AAA domain DUF4746 PF15928.5 ETO29094.1 - 0.011 15.1 1.2 0.011 15.1 1.2 2.4 2 1 0 2 2 1 0 Domain of unknown function (DUF4746) DUF3391 PF11871.8 ETO29094.1 - 0.013 16.1 1.2 0.013 16.1 1.2 3.2 3 1 1 4 4 2 0 Domain of unknown function (DUF3391) AIF_C PF14721.6 ETO29094.1 - 0.026 14.9 7.9 0.026 14.9 7.9 3.3 3 1 0 3 3 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF913 PF06025.12 ETO29094.1 - 0.06 12.3 7.7 0.022 13.7 1.5 2.1 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) PepSY_TM PF03929.16 ETO29094.1 - 0.076 12.7 0.5 0.12 12.0 0.5 1.3 1 0 0 1 1 1 0 PepSY-associated TM region Exonuc_VII_L PF02601.15 ETO29094.1 - 0.25 10.9 15.4 0.025 14.2 4.0 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit ABC2_membrane_2 PF12679.7 ETO29094.1 - 0.31 10.3 0.3 0.39 10.0 0.3 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein UPF0564 PF10595.9 ETO29094.1 - 0.73 8.8 38.8 1.7 7.6 38.8 1.6 1 1 0 1 1 1 0 Uncharacterised protein family UPF0564 RP-C_C PF11800.8 ETO29094.1 - 1.4 9.0 16.2 0.46 10.5 6.2 2.8 3 0 0 3 3 3 0 Replication protein C C-terminal region MDM10 PF12519.8 ETO29094.1 - 1.7 7.4 14.7 0.02 13.8 3.8 2.3 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Ndc1_Nup PF09531.10 ETO29094.1 - 1.7 7.3 13.6 0.54 8.9 7.2 2.2 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup PIP5K PF01504.18 ETO29094.1 - 2.2 7.4 17.3 1.6 7.9 10.4 2.3 2 0 0 2 2 2 0 Phosphatidylinositol-4-phosphate 5-Kinase Connexin PF00029.19 ETO29094.1 - 3.7 7.2 21.1 0.025 14.3 6.5 2.9 3 0 0 3 3 3 0 Connexin Med15 PF09606.10 ETO29094.1 - 4.2 5.9 32.4 7.7 5.1 32.4 1.3 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal DUF4643 PF15485.6 ETO29094.1 - 5.6 6.7 20.0 0.22 11.3 12.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4643) eIF-3_zeta PF05091.12 ETO29094.1 - 6.2 5.7 31.6 0.22 10.5 16.1 2.3 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) RICTOR_N PF14664.6 ETO29094.1 - 7.7 5.4 8.4 22 3.9 8.4 1.7 1 0 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term RNA_pol_Rpc4 PF05132.14 ETO29094.1 - 8.3 6.8 19.8 0.15 12.5 4.8 3.2 3 0 0 3 3 3 0 RNA polymerase III RPC4 CPSF100_C PF13299.6 ETO29094.1 - 9.6 6.4 20.4 0.049 13.8 5.2 3.3 4 0 0 4 4 3 0 Cleavage and polyadenylation factor 2 C-terminal Kelch_3 PF13415.6 ETO29095.1 - 0.0022 18.2 0.0 0.017 15.4 0.0 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29095.1 - 0.081 12.9 0.1 0.43 10.6 0.1 2.2 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO29095.1 - 0.16 12.0 0.0 0.55 10.3 0.0 1.9 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO29095.1 - 0.17 12.2 0.0 1.6 9.1 0.0 2.6 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO29095.1 - 0.19 11.3 0.4 0.54 9.9 0.1 2.0 2 0 0 2 2 2 0 Kelch motif EC042_2821 PF18740.1 ETO29095.1 - 0.19 11.6 4.7 1.7 8.5 1.2 2.4 2 0 0 2 2 2 0 EC042_2821-lke REase SAM_2 PF07647.17 ETO29097.1 - 1.4e-09 37.9 0.6 2.4e-09 37.1 0.6 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO29097.1 - 1.6e-09 38.1 0.4 2.8e-09 37.3 0.4 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) AAA_6 PF12774.7 ETO29097.1 - 0.012 14.6 0.1 0.018 14.0 0.1 1.4 1 0 0 1 1 1 0 Hydrolytic ATP binding site of dynein motor region DUF1515 PF07439.11 ETO29097.1 - 0.018 15.0 0.7 0.018 15.0 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1515) SAM_PNT PF02198.16 ETO29097.1 - 0.044 13.8 0.0 0.096 12.7 0.0 1.6 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain HSBP1 PF06825.12 ETO29097.1 - 0.11 12.4 5.0 0.89 9.5 0.1 3.0 2 1 0 2 2 2 0 Heat shock factor binding protein 1 PfkB PF00294.24 ETO29099.1 - 6.1e-12 45.4 0.3 1.1e-11 44.7 0.3 1.3 1 0 0 1 1 1 1 pfkB family carbohydrate kinase SIS PF01380.22 ETO29099.1 - 0.011 15.5 0.2 0.078 12.8 0.1 2.3 3 0 0 3 3 3 0 SIS domain SIS_2 PF13580.6 ETO29099.1 - 0.063 13.3 0.0 0.14 12.2 0.0 1.5 1 0 0 1 1 1 0 SIS domain T4SS_TraI PF16932.5 ETO29099.1 - 0.12 11.5 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Type IV secretory system, conjugal DNA-protein transfer Pkinase PF00069.25 ETO29101.1 - 1e-12 48.0 0.0 8.6e-12 45.0 0.0 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29101.1 - 0.0076 15.6 0.0 0.034 13.4 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase PcfK PF14058.6 ETO29101.1 - 0.1 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 PcfK-like protein UQ_con PF00179.26 ETO29102.1 - 4.6e-49 165.7 0.0 6e-49 165.3 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO29102.1 - 3.1e-07 30.1 0.0 5e-07 29.5 0.0 1.4 1 1 0 1 1 1 1 Prokaryotic E2 family B RGS-like PF09128.11 ETO29102.1 - 0.0035 17.1 1.5 1.5 8.5 0.1 2.1 2 0 0 2 2 2 2 Regulator of G protein signalling-like domain UEV PF05743.13 ETO29102.1 - 0.014 15.2 0.0 0.026 14.4 0.0 1.4 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 ETO29102.1 - 0.042 14.1 0.0 0.08 13.2 0.0 1.6 2 0 0 2 2 2 0 RWD domain Di19_C PF14571.6 ETO29102.1 - 0.14 12.7 0.1 0.23 12.0 0.1 1.4 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal TcdB_N PF12918.7 ETO29103.1 - 0.062 13.6 0.9 0.17 12.2 0.9 1.8 1 0 0 1 1 1 0 TcdB toxin N-terminal helical domain DUF4062 PF13271.6 ETO29104.1 - 3.8e-11 43.2 0.0 1.6e-10 41.2 0.0 2.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4062) MNNL PF07657.13 ETO29104.1 - 0.11 12.5 1.6 0.43 10.6 0.0 2.5 3 0 0 3 3 3 0 N terminus of Notch ligand TPR_12 PF13424.6 ETO29105.1 - 2.5e-27 94.9 1.9 1.7e-12 47.4 0.1 5.3 3 2 2 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29105.1 - 7e-17 60.7 2.7 7e-05 22.6 0.0 5.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29105.1 - 1.3e-10 40.5 0.8 0.0022 17.9 0.0 5.1 4 0 0 4 4 4 2 Tetratricopeptide repeat NACHT PF05729.12 ETO29105.1 - 9e-08 32.2 0.7 1.8e-06 27.9 0.7 2.6 1 1 0 1 1 1 1 NACHT domain TPR_2 PF07719.17 ETO29105.1 - 5.7e-07 29.2 7.3 1 9.7 0.0 5.4 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29105.1 - 9.9e-07 28.3 12.2 0.47 10.4 0.0 5.9 6 0 0 6 6 5 3 Tetratricopeptide repeat AAA_22 PF13401.6 ETO29105.1 - 3.8e-06 27.2 0.7 2.6e-05 24.5 0.0 2.6 3 0 0 3 3 3 1 AAA domain TPR_8 PF13181.6 ETO29105.1 - 2e-05 24.4 10.1 1.5 9.2 0.1 5.6 6 0 0 6 6 5 3 Tetratricopeptide repeat AAA_16 PF13191.6 ETO29105.1 - 2.3e-05 24.8 0.0 7.3e-05 23.2 0.0 1.8 1 0 0 1 1 1 1 AAA ATPase domain NB-ARC PF00931.22 ETO29105.1 - 0.00017 20.8 0.4 0.00041 19.6 0.4 1.6 1 0 0 1 1 1 1 NB-ARC domain Sigma54_activ_2 PF14532.6 ETO29105.1 - 0.019 15.1 0.0 0.59 10.2 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_24 PF13479.6 ETO29105.1 - 0.026 14.2 0.1 0.087 12.5 0.1 1.8 2 0 0 2 2 2 0 AAA domain AAA_7 PF12775.7 ETO29105.1 - 0.039 13.5 0.0 0.088 12.3 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region TPR_6 PF13174.6 ETO29105.1 - 0.056 14.1 3.3 4.6 8.1 0.1 4.9 6 1 0 6 6 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29105.1 - 0.11 12.3 0.6 23 4.8 0.1 4.1 4 1 0 4 4 4 0 TPR repeat AAA_33 PF13671.6 ETO29105.1 - 0.12 12.5 0.0 2.4 8.3 0.0 2.5 2 0 0 2 2 2 0 AAA domain MIT PF04212.18 ETO29105.1 - 0.24 11.5 1.0 4.2 7.5 0.2 3.1 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO29105.1 - 0.98 9.9 5.1 22 5.7 0.0 4.4 3 1 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO29106.1 - 2.3e-120 389.0 56.5 1.7e-09 38.1 1.1 15.7 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29106.1 - 2.9e-23 82.0 14.8 0.075 13.3 0.1 11.7 2 2 10 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29106.1 - 1.9e-16 60.0 3.5 0.76 8.7 0.0 10.9 2 2 9 11 11 11 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29106.1 - 4.7e-12 45.9 3.3 0.00084 18.7 0.2 5.8 3 2 3 6 6 6 3 WD40-like domain NACHT PF05729.12 ETO29106.1 - 1.7e-07 31.3 0.0 4.2e-07 30.0 0.0 1.7 1 0 0 1 1 1 1 NACHT domain Str_synth PF03088.16 ETO29106.1 - 8.9e-06 25.8 0.4 26 5.0 0.0 6.7 5 1 1 6 6 6 0 Strictosidine synthase Pentapeptide PF00805.22 ETO29106.1 - 1.9e-05 24.2 4.7 4.4e-05 23.0 4.7 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_22 PF13401.6 ETO29106.1 - 4.3e-05 23.8 0.0 0.00012 22.3 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF5319 PF17252.2 ETO29106.1 - 7.7e-05 22.9 0.0 77 3.5 0.0 7.1 4 2 4 8 8 8 0 Family of unknown function (DUF5319) Pentapeptide_4 PF13599.6 ETO29106.1 - 0.0014 18.7 0.5 0.0047 17.1 0.5 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) LZ3wCH PF18517.1 ETO29106.1 - 0.033 14.3 0.1 0.2 11.8 0.1 2.4 1 0 0 1 1 1 0 Leucine zipper with capping helix domain PD40 PF07676.12 ETO29106.1 - 0.056 13.4 19.8 14 5.7 0.0 8.4 9 0 0 9 9 8 0 WD40-like Beta Propeller Repeat Mid2 PF04478.12 ETO29106.1 - 0.071 12.9 0.0 9.4 6.1 0.0 3.8 4 0 0 4 4 4 0 Mid2 like cell wall stress sensor AAA_18 PF13238.6 ETO29106.1 - 0.21 12.1 0.0 0.21 12.1 0.0 3.3 3 2 2 5 5 3 0 AAA domain NYD-SP28_assoc PF14775.6 ETO29106.1 - 0.29 11.3 9.9 14 5.9 0.1 7.8 10 0 0 10 10 9 0 Sperm tail C-terminal domain RNA_helicase PF00910.22 ETO29106.1 - 0.34 11.3 3.0 0.7 10.3 0.0 3.4 3 0 0 3 3 1 0 RNA helicase Pentapeptide_3 PF13576.6 ETO29106.1 - 0.41 10.8 3.7 1.9 8.7 3.7 2.0 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO29106.1 - 1.1 9.4 15.3 6.9 6.8 0.1 7.3 4 2 2 8 8 8 0 Family of unknown function (DUF5570) DUF1652 PF07865.11 ETO29106.1 - 2.2 8.2 3.5 32 4.4 0.0 4.9 8 0 0 8 8 7 0 Protein of unknown function (DUF1652) MIEAP PF16026.5 ETO29107.1 - 1.8e-06 28.3 9.8 2.5e-05 24.6 9.8 2.7 1 1 0 1 1 1 1 Mitochondria-eating protein Mit_proteolip PF08039.11 ETO29107.1 - 0.11 13.0 0.1 0.3 11.6 0.1 1.8 1 0 0 1 1 1 0 Mitochondrial proteolipid Mg_trans_NIPA PF05653.14 ETO29108.1 - 0.011 14.8 0.3 0.013 14.6 0.3 1.1 1 0 0 1 1 1 0 Magnesium transporter NIPA HHH_4 PF14490.6 ETO29108.1 - 0.035 14.1 1.1 0.038 14.0 0.3 1.5 2 0 0 2 2 2 0 Helix-hairpin-helix containing domain MSC PF09402.10 ETO29108.1 - 0.14 11.5 1.2 0.15 11.5 1.2 1.1 1 0 0 1 1 1 0 Man1-Src1p-C-terminal domain Sec23_BS PF08033.12 ETO29109.1 - 8.4e-22 77.7 1.3 1.5e-21 76.9 1.3 1.5 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain Sec23_trunk PF04811.15 ETO29109.1 - 2.3e-19 70.0 0.1 1.2e-17 64.3 0.0 2.8 2 1 0 2 2 2 1 Sec23/Sec24 trunk domain Sec23_helical PF04815.15 ETO29109.1 - 1.3e-16 60.3 0.1 2.6e-16 59.3 0.1 1.5 1 0 0 1 1 1 1 Sec23/Sec24 helical domain GSH_synth_ATP PF03917.17 ETO29110.1 - 7.4e-58 196.1 0.0 1.8e-57 194.8 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic glutathione synthase, ATP binding domain GSH_synthase PF03199.15 ETO29110.1 - 2.6e-31 108.1 1.8 1.1e-30 106.1 0.1 2.9 3 1 0 3 3 3 1 Eukaryotic glutathione synthase Glyco_hydro_16 PF00722.21 ETO29111.1 - 8.2e-10 38.4 1.9 1.9e-09 37.3 1.9 1.5 1 1 0 1 1 1 1 Glycosyl hydrolases family 16 m04gp34like PF12216.8 ETO29111.1 - 0.2 11.2 0.4 0.29 10.7 0.4 1.1 1 0 0 1 1 1 0 Immune evasion protein Bacillus_HBL PF05791.11 ETO29112.1 - 0.0024 17.7 0.6 0.006 16.4 0.6 1.7 1 0 0 1 1 1 1 Bacillus haemolytic enterotoxin (HBL) Surface_Ag_2 PF01617.17 ETO29112.1 - 0.061 12.7 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 Surface antigen Pkinase PF00069.25 ETO29114.1 - 8.7e-39 133.5 0.3 9.8e-39 133.3 0.3 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29114.1 - 8.5e-21 74.4 0.1 1.1e-20 74.1 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO29114.1 - 1.2e-06 28.0 2.2 1.8e-06 27.4 2.2 1.4 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETO29114.1 - 3.5e-06 26.8 1.1 4.5e-06 26.4 1.1 1.1 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ETO29114.1 - 0.00033 20.7 0.7 0.0087 16.0 0.2 2.1 1 1 1 2 2 2 2 Phosphotransferase enzyme family YrbL-PhoP_reg PF10707.9 ETO29114.1 - 0.0054 16.3 1.3 0.009 15.6 0.1 1.9 2 1 1 3 3 3 1 PhoP regulatory network protein YrbL FTA2 PF13095.6 ETO29114.1 - 0.0082 15.8 0.9 0.038 13.6 0.9 2.0 1 1 0 1 1 1 1 Kinetochore Sim4 complex subunit FTA2 Glyco_hydro_66 PF13199.6 ETO29114.1 - 0.024 13.3 0.2 0.028 13.1 0.2 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 66 Choline_kinase PF01633.20 ETO29114.1 - 0.029 14.0 2.1 0.056 13.0 2.1 1.7 1 1 0 1 1 1 0 Choline/ethanolamine kinase Pkinase_fungal PF17667.1 ETO29114.1 - 0.66 8.7 5.3 0.18 10.6 2.2 1.6 1 1 0 2 2 2 0 Fungal protein kinase adh_short PF00106.25 ETO29115.1 - 1.9e-22 79.7 0.0 3e-22 79.0 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO29115.1 - 1.9e-10 40.7 0.0 2.9e-10 40.1 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase DUF1776 PF08643.10 ETO29115.1 - 3e-07 30.1 0.0 4.7e-07 29.5 0.0 1.2 1 0 0 1 1 1 1 Fungal family of unknown function (DUF1776) Mucin PF01456.17 ETO29115.1 - 0.00019 21.4 10.0 0.00028 20.9 10.0 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein KR PF08659.10 ETO29115.1 - 0.00088 19.2 0.0 0.0018 18.2 0.0 1.6 2 0 0 2 2 2 1 KR domain Colipase-like PF15083.6 ETO29115.1 - 0.0037 17.3 0.2 0.0089 16.1 0.2 1.5 1 0 0 1 1 1 1 Colipase-like Dicty_REP PF05086.12 ETO29115.1 - 0.0081 14.2 0.5 0.0094 14.0 0.5 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein SR-25 PF10500.9 ETO29116.1 - 0.0005 19.7 25.3 0.0007 19.3 25.3 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein MFMR_assoc PF16596.5 ETO29116.1 - 0.018 15.5 17.5 0.025 15.0 17.5 1.3 1 0 0 1 1 1 0 Disordered region downstream of MFMR SPATA3 PF15662.5 ETO29116.1 - 0.58 10.8 12.9 0.75 10.4 12.9 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family SURF2 PF05477.11 ETO29116.1 - 0.88 9.2 21.6 1 9.0 21.6 1.0 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Presenilin PF01080.17 ETO29116.1 - 2.7 6.6 20.1 2.8 6.6 20.1 1.0 1 0 0 1 1 1 0 Presenilin Nop14 PF04147.12 ETO29116.1 - 3.7 5.6 25.2 4.2 5.4 25.2 1.0 1 0 0 1 1 1 0 Nop14-like family NPR3 PF03666.13 ETO29116.1 - 8.9 5.0 23.3 9.4 4.9 23.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2126 PF09899.9 ETO29118.1 - 0.26 9.3 2.8 0.26 9.3 2.8 1.0 1 0 0 1 1 1 0 Putative amidoligase enzyme (DUF2126) RPN2_C PF18004.1 ETO29118.1 - 0.85 9.5 16.2 1.1 9.1 16.2 1.1 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Connexin PF00029.19 ETO29118.1 - 0.9 9.3 6.3 0.9 9.3 6.3 1.1 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 ETO29118.1 - 0.96 8.3 3.1 1 8.2 3.1 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator RR_TM4-6 PF06459.12 ETO29118.1 - 1.2 8.9 11.4 1.3 8.7 11.4 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 EOS1 PF12326.8 ETO29118.1 - 1.5 8.7 3.3 1.7 8.5 3.3 1.1 1 0 0 1 1 1 0 N-glycosylation protein Presenilin PF01080.17 ETO29118.1 - 3.6 6.3 6.8 3.8 6.2 6.8 1.0 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO29118.1 - 3.6 7.6 5.6 4.1 7.4 5.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO29118.1 - 8.5 5.5 7.6 10 5.3 7.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2058 PF09831.9 ETO29118.1 - 8.8 6.5 15.3 11 6.2 15.3 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2058) DUF4337 PF14235.6 ETO29118.1 - 8.9 6.4 8.0 12 6.0 8.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) G-alpha PF00503.20 ETO29119.1 - 1.2e-22 80.5 7.6 1.2e-21 77.3 7.6 2.0 1 1 0 1 1 1 1 G-protein alpha subunit AAA_29 PF13555.6 ETO29119.1 - 0.085 12.6 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO29119.1 - 0.089 13.2 0.0 0.16 12.3 0.0 1.4 1 0 0 1 1 1 0 AAA ATPase domain AAA_18 PF13238.6 ETO29119.1 - 0.31 11.6 3.0 1.8 9.1 1.0 2.8 1 1 0 1 1 1 0 AAA domain Aldedh PF00171.22 ETO29120.1 - 0.054 12.0 0.0 0.072 11.6 0.0 1.1 1 0 0 1 1 1 0 Aldehyde dehydrogenase family GlcNAc PF11397.8 ETO29121.1 - 1.1e-52 179.6 1.7 1.6e-23 83.8 0.0 3.1 2 1 1 3 3 3 3 Glycosyltransferase (GlcNAc) Hyr1 PF15789.5 ETO29121.1 - 0.0036 16.8 0.0 0.0082 15.7 0.0 1.6 1 0 0 1 1 1 1 Hyphally regulated cell wall GPI-anchored protein 1 RGS PF00615.19 ETO29122.1 - 0.0092 16.2 2.3 0.012 15.8 0.4 2.2 2 1 0 2 2 2 1 Regulator of G protein signaling domain GWT1 PF06423.12 ETO29122.1 - 0.13 12.3 2.2 0.33 11.1 2.2 1.7 1 0 0 1 1 1 0 GWT1 DUF4181 PF13789.6 ETO29122.1 - 0.16 12.3 8.9 0.4 11.0 8.9 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4181) D123 PF07065.14 ETO29123.1 - 1.3e-13 50.8 5.6 8.8e-06 25.1 0.1 3.1 3 0 0 3 3 3 3 D123 RGS PF00615.19 ETO29124.1 - 7.9e-06 26.1 0.5 1.5e-05 25.2 0.5 1.5 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF4144 PF13642.6 ETO29124.1 - 0.016 15.7 0.1 0.03 14.9 0.1 1.4 1 0 0 1 1 1 0 protein structure with unknown function EF-hand_7 PF13499.6 ETO29125.1 - 2.7e-14 53.4 1.7 2.7e-14 53.4 1.7 2.2 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO29125.1 - 3.7e-13 48.3 8.2 2.5e-06 26.7 0.9 2.5 2 0 0 2 2 2 2 EF hand EF-hand_1 PF00036.32 ETO29125.1 - 3.2e-12 45.1 11.0 9.3e-07 28.0 0.6 2.8 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO29125.1 - 1.1e-09 37.5 9.0 5.5e-05 22.8 0.6 2.9 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ETO29125.1 - 4.3e-07 29.7 6.0 0.0058 16.4 1.1 2.6 1 1 1 2 2 2 2 EF-hand domain pair Dockerin_1 PF00404.18 ETO29125.1 - 0.0012 19.0 1.3 0.025 14.7 0.1 2.8 3 0 0 3 3 3 1 Dockerin type I domain SPARC_Ca_bdg PF10591.9 ETO29125.1 - 0.0013 19.0 5.9 0.0075 16.6 5.9 2.3 1 1 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region RNA_pol_Rpb5_N PF03871.14 ETO29125.1 - 0.075 13.6 0.9 0.28 11.8 0.0 2.2 2 1 0 2 2 2 0 RNA polymerase Rpb5, N-terminal domain EF-hand_4 PF12763.7 ETO29125.1 - 0.56 10.2 3.0 23 5.0 0.1 2.8 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand adh_short_C2 PF13561.6 ETO29126.1 - 1.6e-26 93.3 0.1 2.4e-21 76.4 0.2 3.0 2 1 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO29126.1 - 8.6e-20 71.0 0.3 5.1e-19 68.5 0.3 2.0 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO29126.1 - 0.14 12.0 0.1 0.26 11.2 0.1 1.4 1 0 0 1 1 1 0 KR domain Sugar_tr PF00083.24 ETO29127.1 - 4.3e-06 25.9 0.9 4.3e-06 25.9 0.9 2.0 1 1 1 2 2 2 1 Sugar (and other) transporter MFS_1 PF07690.16 ETO29127.1 - 2.3e-05 23.5 7.7 0.00013 21.0 8.1 1.8 1 1 0 1 1 1 1 Major Facilitator Superfamily PsaL PF02605.15 ETO29127.1 - 0.11 12.1 0.5 0.22 11.2 0.1 1.6 2 0 0 2 2 2 0 Photosystem I reaction centre subunit XI Disintegrin PF00200.23 ETO29129.1 - 6.1e-14 52.6 31.6 6.1e-14 52.6 31.6 8.3 4 3 3 7 7 7 1 Disintegrin WW PF00397.26 ETO29129.1 - 2.6e-08 33.8 3.0 6.5e-08 32.5 3.0 1.8 1 0 0 1 1 1 1 WW domain Reprolysin_2 PF13574.6 ETO29129.1 - 9.7e-05 22.3 3.3 0.00011 22.1 1.2 2.3 2 0 0 2 2 2 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_4 PF13583.6 ETO29129.1 - 0.0092 15.6 0.6 0.023 14.3 0.6 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4718 PF15842.5 ETO29129.1 - 0.067 13.0 5.5 0.2 11.5 5.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) Reprolysin_3 PF13582.6 ETO29129.1 - 0.12 13.0 0.2 0.4 11.2 0.2 2.0 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like V_ATPase_I PF01496.19 ETO29129.1 - 0.19 9.6 2.0 0.96 7.3 2.2 1.7 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family ATP-synt_B PF00430.18 ETO29129.1 - 0.63 10.1 8.4 1 9.5 8.4 1.2 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) FAM176 PF14851.6 ETO29129.1 - 8 6.1 6.4 30 4.2 6.4 1.9 1 1 0 1 1 1 0 FAM176 family Cadherin_pro PF08758.11 ETO29130.1 - 0.18 12.0 2.9 1.4 9.1 0.5 2.5 2 0 0 2 2 2 0 Cadherin prodomain like MRG PF05712.13 ETO29131.1 - 2.2e-25 89.1 12.9 5.7e-20 71.5 6.2 2.9 2 1 0 2 2 2 2 MRG RF-1 PF00472.20 ETO29131.1 - 2.3 8.2 11.5 0.66 9.9 7.9 2.0 2 0 0 2 2 2 0 RF-1 domain WD40 PF00400.32 ETO29132.1 - 1.5e-135 437.1 49.4 1e-09 38.9 0.1 16.7 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29132.1 - 3.8e-27 94.4 17.1 0.074 13.4 0.0 13.7 1 1 10 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29132.1 - 1.6e-20 73.4 1.2 1.5 7.7 0.0 12.0 4 2 7 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO29132.1 - 1.6e-11 44.4 0.0 4.5e-11 42.9 0.0 1.8 2 0 0 2 2 2 1 NACHT domain Pentapeptide PF00805.22 ETO29132.1 - 1.4e-06 27.8 2.9 3.1e-06 26.7 2.9 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO29132.1 - 0.00014 21.9 0.2 0.0005 20.2 0.2 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO29132.1 - 0.016 15.5 0.0 0.05 13.9 0.0 1.8 1 0 0 1 1 1 0 AAA domain Pentapeptide_3 PF13576.6 ETO29132.1 - 0.024 14.8 1.0 0.073 13.2 1.0 1.8 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Mid2 PF04478.12 ETO29132.1 - 0.026 14.4 1.2 2.4 8.0 0.0 4.6 5 1 1 6 6 6 0 Mid2 like cell wall stress sensor AAA_5 PF07728.14 ETO29132.1 - 0.079 13.0 0.1 2.2 8.3 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETO29132.1 - 0.15 12.6 0.0 0.15 12.6 0.0 3.3 3 0 0 3 3 3 0 AAA domain DUF5570 PF17731.1 ETO29132.1 - 0.35 11.0 14.8 3.1 7.9 1.0 7.1 3 2 4 7 7 7 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO29132.1 - 0.45 10.5 19.9 43 4.2 0.0 8.6 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat ApoL PF05461.11 ETO29133.1 - 0.069 12.5 0.1 0.11 11.8 0.1 1.3 1 0 0 1 1 1 0 Apolipoprotein L DUF3874 PF12990.7 ETO29135.1 - 0.092 13.1 0.8 0.24 11.7 0.7 1.9 1 1 0 1 1 1 0 Domain of unknonw function from B. Theta Gene description (DUF3874) BORCS7 PF16088.5 ETO29136.1 - 0.031 14.5 0.3 0.045 14.0 0.3 1.4 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 7 AAA_lid_2 PF17863.1 ETO29137.1 - 0.15 11.9 0.0 0.32 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA lid domain DUF2672 PF10878.8 ETO29138.1 - 0.0074 16.2 0.4 0.026 14.5 0.4 2.0 1 0 0 1 1 1 1 Protein of unknown function (DUF2672) V-SNARE PF05008.15 ETO29138.1 - 0.025 14.9 4.4 0.025 14.9 4.4 4.5 4 0 0 4 4 4 0 Vesicle transport v-SNARE protein N-terminus ZapB PF06005.12 ETO29138.1 - 0.056 13.9 0.4 0.056 13.9 0.4 5.2 5 0 0 5 5 5 0 Cell division protein ZapB DUF4140 PF13600.6 ETO29138.1 - 0.29 11.6 17.0 4.3 7.8 0.1 4.6 4 0 0 4 4 4 0 N-terminal domain of unknown function (DUF4140) BLOC1_2 PF10046.9 ETO29138.1 - 0.29 11.4 27.9 2.5 8.5 2.8 4.4 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 MAD PF05557.13 ETO29138.1 - 0.92 7.8 37.4 0.052 11.9 18.0 3.1 3 0 0 3 3 3 0 Mitotic checkpoint protein CD20 PF04103.15 ETO29138.1 - 1.9 8.6 7.5 0.29 11.2 1.3 2.5 3 0 0 3 3 3 0 CD20-like family Tropomyosin_1 PF12718.7 ETO29138.1 - 2.9 8.1 49.3 0.052 13.7 2.7 4.6 5 0 0 5 5 5 0 Tropomyosin like DUF948 PF06103.11 ETO29138.1 - 5.3 7.4 14.9 7.1 7.0 1.7 4.4 4 0 0 4 4 4 0 Bacterial protein of unknown function (DUF948) 7tm_1 PF00001.21 ETO29138.1 - 6.6 6.0 7.7 46 3.2 5.2 3.0 2 1 0 2 2 2 0 7 transmembrane receptor (rhodopsin family) Prefoldin_2 PF01920.20 ETO29138.1 - 9.6 6.2 41.1 1.1 9.3 13.3 4.5 4 2 0 4 4 4 0 Prefoldin subunit 7tm_1 PF00001.21 ETO29139.1 - 0.0011 18.4 2.8 0.0018 17.7 2.8 1.5 1 1 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) DUF4720 PF15846.5 ETO29139.1 - 0.099 12.5 0.2 0.17 11.7 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4720) DUF2877 PF11392.8 ETO29140.1 - 0.34 11.7 2.4 0.39 11.4 0.9 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2877) Conotoxin PF02950.17 ETO29140.1 - 2.8 9.0 5.4 1.8 9.7 1.0 2.9 3 1 0 3 3 3 0 Conotoxin GTA_holin_3TM PF11351.8 ETO29140.1 - 4.5 7.8 7.6 1 9.9 4.0 1.9 2 0 0 2 2 2 0 Holin of 3TMs, for gene-transfer release Syndecan PF01034.20 ETO29141.1 - 0.15 12.0 0.4 0.15 12.0 0.4 2.3 3 0 0 3 3 3 0 Syndecan domain NOA36 PF06524.12 ETO29142.1 - 0.47 9.7 8.3 0.63 9.3 8.3 1.3 1 0 0 1 1 1 0 NOA36 protein DUF2457 PF10446.9 ETO29142.1 - 1.4 7.9 10.1 2.1 7.4 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Presenilin PF01080.17 ETO29142.1 - 9 4.9 6.0 12 4.6 6.0 1.1 1 0 0 1 1 1 0 Presenilin Beach PF02138.18 ETO29143.1 - 7.2e-121 402.8 0.4 9.6e-121 402.4 0.4 1.2 1 0 0 1 1 1 1 Beige/BEACH domain PH_BEACH PF14844.6 ETO29143.1 - 2.3e-09 37.2 0.2 4.7e-09 36.3 0.2 1.5 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ETO29143.1 - 1.4e-06 28.9 0.1 7.6e-05 23.4 0.0 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Adap_comp_sub PF00928.21 ETO29144.1 - 1.3e-75 254.2 0.9 1.6e-75 253.9 0.9 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family Urocanase PF01175.18 ETO29145.1 - 0.086 12.5 0.1 0.13 11.9 0.1 1.2 1 0 0 1 1 1 0 Urocanase Rossmann-like domain Abhydrolase_3 PF07859.13 ETO29146.1 - 1e-27 97.4 0.0 1.4e-27 96.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETO29146.1 - 4.2e-17 62.1 0.3 2e-16 59.9 0.3 1.8 1 1 0 1 1 1 1 Steryl acetyl hydrolase COesterase PF00135.28 ETO29146.1 - 0.014 14.3 0.1 0.21 10.4 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family Hydrolase_4 PF12146.8 ETO29146.1 - 0.015 14.6 1.0 0.12 11.6 1.0 2.1 1 1 0 1 1 1 0 Serine aminopeptidase, S33 WD40 PF00400.32 ETO29148.1 - 2.3e-36 123.2 9.8 6.1e-08 33.2 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO29148.1 - 9.4e-13 47.8 1.2 0.048 12.6 0.0 6.0 2 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO29148.1 - 1.1e-12 48.0 0.4 0.08 13.3 0.0 6.5 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO29148.1 - 2.5e-07 30.4 3.4 0.36 10.8 0.2 5.5 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO29148.1 - 0.0015 17.2 0.2 0.67 8.4 0.0 2.8 1 1 2 3 3 3 2 Cytochrome D1 heme domain WD40_like PF17005.5 ETO29148.1 - 0.0028 17.0 5.6 0.019 14.3 0.5 3.4 2 1 0 3 3 3 1 WD40-like domain Nbas_N PF15492.6 ETO29148.1 - 0.0045 16.4 5.8 5.9 6.1 0.0 4.7 2 1 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Str_synth PF03088.16 ETO29148.1 - 0.0051 16.9 0.0 0.49 10.6 0.0 3.6 2 1 1 3 3 3 1 Strictosidine synthase MapZ_EC1 PF18041.1 ETO29148.1 - 0.67 10.2 4.3 1.4 9.1 4.3 1.6 1 0 0 1 1 1 0 MapZ extracellular domain 1 Cnd3 PF12719.7 ETO29149.1 - 9.7e-58 195.7 2.8 1.5e-57 195.1 2.8 1.3 1 0 0 1 1 1 1 Nuclear condensing complex subunits, C-term domain RMP PF14996.6 ETO29149.1 - 0.00083 19.6 0.3 0.00083 19.6 0.3 2.8 2 0 0 2 2 2 1 Retinal Maintenance HisG PF01634.18 ETO29149.1 - 0.11 12.5 0.1 0.2 11.6 0.1 1.4 1 0 0 1 1 1 0 ATP phosphoribosyltransferase DUF3926 PF13080.6 ETO29149.1 - 0.11 12.4 0.3 0.11 12.4 0.3 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3926) Casc1_N PF15927.5 ETO29149.1 - 0.16 11.7 5.4 0.091 12.4 2.5 2.1 1 1 1 2 2 2 0 Cancer susceptibility candidate 1 N-terminus Mer2 PF09074.10 ETO29149.1 - 0.16 11.8 6.1 0.081 12.7 2.9 2.1 2 0 0 2 2 2 0 Mer2 RIH_assoc PF08454.11 ETO29150.1 - 0.0004 20.2 0.0 0.62 10.0 0.0 2.9 2 1 1 3 3 3 2 RyR and IP3R Homology associated Xpo1 PF08389.12 ETO29150.1 - 0.0078 16.3 0.1 0.79 9.8 0.0 2.7 2 0 0 2 2 2 1 Exportin 1-like protein VHS PF00790.19 ETO29150.1 - 0.021 14.7 0.3 0.051 13.4 0.3 1.7 1 0 0 1 1 1 0 VHS domain MIX PF18529.1 ETO29151.1 - 0.027 14.2 0.5 0.041 13.6 0.5 1.3 1 0 0 1 1 1 0 Mitochondrial membrane-anchored proteins CxC1 PF18802.1 ETO29151.1 - 0.041 14.0 0.0 0.09 12.9 0.0 1.6 1 0 0 1 1 1 0 CxC1 like cysteine cluster associated with KDZ transposases ERM PF00769.19 ETO29152.1 - 0.00053 19.9 26.8 0.00062 19.6 14.8 2.2 1 1 0 2 2 2 2 Ezrin/radixin/moesin family DUF3037 PF11236.8 ETO29152.1 - 0.017 15.6 3.5 0.71 10.3 0.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) HrpB_C PF08482.10 ETO29152.1 - 0.08 13.4 0.4 0.21 12.0 0.4 1.7 1 0 0 1 1 1 0 ATP-dependent helicase C-terminal GHMP_kinases_C PF08544.13 ETO29152.1 - 0.68 10.3 2.2 11 6.5 0.6 3.1 2 1 1 3 3 3 0 GHMP kinases C terminal DUF724 PF05266.14 ETO29152.1 - 9 6.1 22.8 0.55 10.0 15.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF724) WD40 PF00400.32 ETO29155.1 - 3.3e-44 148.0 28.6 4e-08 33.8 0.5 7.5 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29155.1 - 1.5e-10 41.2 2.7 0.045 14.0 0.1 5.7 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29155.1 - 5.7e-09 35.2 14.4 0.072 11.7 0.3 5.5 2 1 2 5 5 5 5 Nucleoporin Nup120/160 ABC_tran PF00005.27 ETO29156.1 - 7.4e-21 75.1 0.2 2e-20 73.7 0.0 1.7 2 0 0 2 2 2 1 ABC transporter AAA_21 PF13304.6 ETO29156.1 - 0.01 15.7 4.3 2.3 8.0 1.7 2.8 2 1 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system Unstab_antitox PF09720.10 ETO29156.1 - 0.39 10.8 3.4 0.16 12.1 0.5 1.8 2 0 0 2 2 2 0 Putative addiction module component AAA_28 PF13521.6 ETO29156.1 - 0.47 10.7 2.1 1.8 8.8 1.6 2.3 2 1 0 2 2 2 0 AAA domain ABC2_membrane PF01061.24 ETO29157.1 - 8.4e-32 110.3 19.0 3.7e-27 95.1 9.2 2.3 2 0 0 2 2 2 2 ABC-2 type transporter ABC2_membrane_3 PF12698.7 ETO29157.1 - 2.6e-07 30.1 10.7 3.3e-07 29.8 8.1 2.0 2 0 0 2 2 2 1 ABC-2 family transporter protein zf-RanBP PF00641.18 ETO29158.1 - 0.00063 19.0 0.8 0.0011 18.3 0.8 1.3 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others zf-HIT PF04438.16 ETO29158.1 - 0.55 10.2 2.9 7.7 6.5 0.1 2.2 1 1 1 2 2 2 0 HIT zinc finger Vps36-NZF-N PF16988.5 ETO29158.1 - 6.2 6.3 12.7 3.2 7.2 6.9 3.0 2 1 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain CAP_GLY PF01302.25 ETO29159.1 - 1.8e-05 24.7 0.1 4.5e-05 23.4 0.0 1.6 2 0 0 2 2 2 1 CAP-Gly domain WD40 PF00400.32 ETO29160.1 - 7.1e-60 197.6 15.6 6.8e-09 36.2 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29160.1 - 4.3e-17 62.2 0.7 4.2e-05 23.7 0.0 6.3 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29160.1 - 3.1e-12 46.1 0.5 0.0061 15.6 0.0 5.6 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO29160.1 - 9.5e-10 37.7 8.0 0.59 8.7 0.0 6.0 1 1 5 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29160.1 - 6.5e-07 29.0 0.2 0.29 10.4 0.0 3.5 2 1 1 3 3 3 3 WD40-like domain Nbas_N PF15492.6 ETO29160.1 - 0.0011 18.4 0.6 0.23 10.8 0.1 3.3 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO29160.1 - 0.0016 18.3 0.2 11 6.1 0.0 3.7 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO29160.1 - 0.0021 18.1 0.3 0.089 12.9 0.0 3.4 3 1 2 5 5 5 1 Strictosidine synthase EF-hand_1 PF00036.32 ETO29163.1 - 0.0072 15.8 0.1 0.026 14.1 0.0 2.0 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO29163.1 - 0.031 14.2 0.2 0.33 11.0 0.0 2.6 2 1 1 3 3 3 0 EF-hand domain EF-hand_7 PF13499.6 ETO29163.1 - 0.11 13.0 0.4 1.1 9.8 0.4 2.6 1 1 0 1 1 1 0 EF-hand domain pair WD40 PF00400.32 ETO29164.1 - 6.1e-63 207.3 12.9 4.7e-10 39.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29164.1 - 8.1e-24 83.7 1.8 0.00044 20.5 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29164.1 - 4.9e-12 45.5 0.2 0.039 12.9 0.0 6.2 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO29164.1 - 3.5e-11 43.3 0.1 2.8e-06 27.4 0.0 3.5 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO29164.1 - 9.7e-09 35.0 0.1 0.078 12.3 0.2 3.3 3 0 0 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO29164.1 - 4.6e-06 26.4 0.4 9.3 6.3 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO29164.1 - 4.8e-06 26.7 1.0 7.3 6.7 0.0 5.7 2 2 3 6 6 6 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO29164.1 - 5.1e-06 25.3 0.2 0.15 10.6 0.0 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO29164.1 - 1.1e-05 24.3 1.6 0.81 8.2 0.0 5.1 2 2 4 6 6 6 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO29164.1 - 0.018 13.8 1.8 25 3.5 0.0 4.0 1 1 3 4 4 4 0 Nup133 N terminal like DUF2963 PF11178.8 ETO29164.1 - 0.023 14.4 0.3 0.58 9.9 0.1 3.4 2 1 0 2 2 2 0 Protein of unknown function (DUF2963) nos_propeller PF18764.1 ETO29164.1 - 0.054 13.4 0.0 1.7 8.6 0.0 3.2 2 1 2 4 4 4 0 Nitrous oxide reductase propeller repeat Seryl_tRNA_N PF02403.22 ETO29165.1 - 4.1e-11 43.1 26.4 3.8e-05 23.9 25.8 2.5 1 1 1 2 2 2 1 Seryl-tRNA synthetase N-terminal domain T3SSipB PF16535.5 ETO29165.1 - 0.005 17.3 5.0 0.012 16.1 5.2 1.5 1 1 0 1 1 1 1 Type III cell invasion protein SipB SRA1 PF07304.11 ETO29165.1 - 0.0051 16.6 4.4 0.13 12.1 0.8 2.1 2 0 0 2 2 2 2 Steroid receptor RNA activator (SRA1) V_ATPase_I PF01496.19 ETO29165.1 - 0.0085 14.1 9.2 0.01 13.8 9.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family NOD PF06816.13 ETO29165.1 - 0.018 14.7 0.0 0.042 13.5 0.0 1.6 1 0 0 1 1 1 0 NOTCH protein DUF4407 PF14362.6 ETO29165.1 - 0.17 11.2 6.6 0.2 11.0 6.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF948 PF06103.11 ETO29165.1 - 0.41 10.9 2.5 4.1 7.7 0.2 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.15 ETO29165.1 - 0.59 9.6 6.5 0.76 9.3 6.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Tho2 PF11262.8 ETO29165.1 - 0.7 9.0 12.9 0.31 10.2 7.7 2.0 2 0 0 2 2 2 0 Transcription factor/nuclear export subunit protein 2 Snapin_Pallidin PF14712.6 ETO29165.1 - 0.86 10.1 12.7 0.59 10.6 1.4 2.4 2 0 0 2 2 2 0 Snapin/Pallidin NPV_P10 PF05531.12 ETO29165.1 - 1.3 9.5 5.9 1 9.8 0.6 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein AAA_23 PF13476.6 ETO29165.1 - 6.1 7.3 18.7 8.7 6.8 18.7 1.2 1 0 0 1 1 1 0 AAA domain DUF4446 PF14584.6 ETO29165.1 - 7.8 6.5 16.1 14 5.6 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) tRNA-synt_2b PF00587.25 ETO29166.1 - 3e-40 138.1 0.0 3.6e-40 137.8 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) SAPS PF04499.15 ETO29168.1 - 0.0058 15.5 4.1 0.0074 15.1 4.1 1.1 1 0 0 1 1 1 1 SIT4 phosphatase-associated protein Pox_Ag35 PF03286.14 ETO29168.1 - 0.12 12.1 13.9 0.023 14.5 6.6 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Drf_GBD PF06371.13 ETO29168.1 - 0.15 11.7 6.7 0.85 9.2 1.0 2.1 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain RRN3 PF05327.11 ETO29168.1 - 0.47 8.9 5.7 0.68 8.4 5.7 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_ligase_OB_2 PF14743.6 ETO29169.1 - 0.19 11.7 0.2 0.44 10.6 0.2 1.5 1 0 0 1 1 1 0 DNA ligase OB-like domain Hydin_ADK PF17213.3 ETO29169.1 - 5.8 7.1 9.3 2.2 8.5 2.9 2.3 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain Calpain_u2 PF16648.5 ETO29171.1 - 0.042 14.3 0.1 0.059 13.8 0.1 1.2 1 0 0 1 1 1 0 Unstructured region on Calpain-3 Acatn PF13000.7 ETO29172.1 - 3.9e-59 200.6 19.0 3.1e-31 108.5 12.4 3.4 1 1 1 2 2 2 2 Acetyl-coenzyme A transporter 1 MFS_1 PF07690.16 ETO29172.1 - 0.00048 19.2 2.7 0.00048 19.2 2.7 2.5 3 0 0 3 3 3 2 Major Facilitator Superfamily CcmH PF03918.14 ETO29172.1 - 0.16 11.2 0.1 0.37 10.1 0.1 1.5 1 0 0 1 1 1 0 Cytochrome C biogenesis protein ECF_trnsprt PF12822.7 ETO29172.1 - 3.7 7.6 13.7 4.4 7.4 9.1 3.1 2 1 0 2 2 2 0 ECF transporter, substrate-specific component TLD PF07534.16 ETO29173.1 - 2.4e-14 53.7 0.8 4.8e-14 52.8 0.8 1.5 1 1 0 1 1 1 1 TLD Renin_r PF07850.14 ETO29173.1 - 0.044 14.4 0.0 0.13 12.9 0.0 1.7 2 0 0 2 2 2 0 Renin receptor-like protein Sec1 PF00995.23 ETO29174.1 - 4e-66 224.5 0.3 5.4e-66 224.0 0.3 1.1 1 0 0 1 1 1 1 Sec1 family YlbD_coat PF14071.6 ETO29174.1 - 2.6 8.3 9.1 0.14 12.4 1.9 2.5 2 1 1 3 3 3 0 Putative coat protein BEX PF04538.12 ETO29174.1 - 9.8 6.8 7.5 0.66 10.6 1.0 2.2 2 0 0 2 2 2 0 Brain expressed X-linked like family Snf7 PF03357.21 ETO29176.1 - 7.2e-20 71.3 27.9 1.6e-12 47.4 10.6 2.1 2 0 0 2 2 2 2 Snf7 DUF948 PF06103.11 ETO29176.1 - 0.0016 18.7 2.4 0.061 13.6 0.2 2.4 2 0 0 2 2 2 1 Bacterial protein of unknown function (DUF948) DUF2797 PF10977.8 ETO29176.1 - 0.0053 16.7 1.0 0.0053 16.7 1.0 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF2797) Rsbr_N PF08678.10 ETO29176.1 - 0.012 15.7 5.5 0.18 11.9 0.3 2.2 2 0 0 2 2 2 0 Rsbr N terminal DUF3993 PF13158.6 ETO29176.1 - 0.024 14.9 1.1 0.043 14.0 0.2 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3993) LMBR1 PF04791.16 ETO29176.1 - 0.032 13.2 3.1 0.063 12.2 3.1 1.4 1 1 0 1 1 1 0 LMBR1-like membrane protein PAS_9 PF13426.7 ETO29176.1 - 0.054 13.7 0.6 0.29 11.4 0.1 2.2 2 1 0 2 2 2 0 PAS domain DUF1664 PF07889.12 ETO29176.1 - 0.11 12.6 10.0 1.9 8.5 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) ETRAMP PF09716.10 ETO29176.1 - 0.12 12.4 0.3 0.12 12.4 0.3 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Anti-adapt_IraP PF10796.9 ETO29176.1 - 0.2 12.2 6.2 0.17 12.5 2.1 2.3 2 0 0 2 2 2 0 Sigma-S stabilisation anti-adaptor protein B12-binding_2 PF02607.17 ETO29176.1 - 0.25 11.8 2.3 0.48 10.9 0.5 2.2 2 0 0 2 2 2 0 B12 binding domain DUF4795 PF16043.5 ETO29176.1 - 0.35 10.5 15.5 1.8 8.1 15.5 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4795) DUF4446 PF14584.6 ETO29176.1 - 1.1 9.2 6.7 0.66 9.9 0.2 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) FapA PF03961.13 ETO29176.1 - 1.3 7.5 10.7 0.41 9.2 5.9 1.9 2 0 0 2 2 2 0 Flagellar Assembly Protein A TFR_dimer PF04253.15 ETO29176.1 - 1.7 8.8 7.5 2.4 8.3 2.7 2.6 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain TMPIT PF07851.13 ETO29176.1 - 1.9 7.7 14.2 0.93 8.7 1.2 2.1 2 0 0 2 2 2 0 TMPIT-like protein Alb1 PF09135.11 ETO29176.1 - 3 8.8 10.9 0.66 10.9 6.6 2.0 2 0 0 2 2 2 0 Alb1 CENP-H PF05837.12 ETO29176.1 - 3.3 8.2 10.8 4.3 7.8 4.1 2.3 2 0 0 2 2 2 0 Centromere protein H (CENP-H) CENP-O PF09496.10 ETO29176.1 - 6.5 6.7 7.8 25 4.8 7.8 1.8 1 1 0 1 1 1 0 Cenp-O kinetochore centromere component PMSI1 PF15322.6 ETO29177.1 - 0.26 10.7 1.7 0.28 10.6 1.7 1.0 1 0 0 1 1 1 0 Protein missing in infertile sperm 1, putative Thioredoxin PF00085.20 ETO29178.1 - 1.1e-06 28.5 0.4 2.6e-06 27.4 0.1 1.7 2 0 0 2 2 2 1 Thioredoxin Phosducin PF02114.16 ETO29178.1 - 5.1e-06 25.6 1.0 6.7e-06 25.2 1.0 1.1 1 0 0 1 1 1 1 Phosducin Microtub_bind PF13931.6 ETO29178.1 - 0.036 14.5 0.5 0.036 14.5 0.5 2.0 1 1 1 2 2 2 0 Kinesin-associated microtubule-binding CemA PF03040.14 ETO29178.1 - 0.26 11.2 1.9 0.41 10.5 1.9 1.4 1 0 0 1 1 1 0 CemA family PCRF PF03462.18 ETO29178.1 - 1.3 8.9 7.9 2.2 8.1 7.9 1.4 1 1 0 1 1 1 0 PCRF domain DUF4407 PF14362.6 ETO29178.1 - 1.3 8.3 5.5 1.7 7.9 5.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 ETO29178.1 - 3.5 6.6 7.3 4.9 6.1 7.3 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 WD40 PF00400.32 ETO29181.1 - 4.9e-10 39.8 12.2 7.6e-06 26.6 4.6 4.3 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29181.1 - 1.3e-05 25.4 0.0 0.24 11.7 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29181.1 - 0.00015 20.6 0.2 0.0085 14.8 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO29182.1 - 6.9e-15 55.2 6.2 5e-07 30.3 0.2 3.5 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29182.1 - 5.9e-07 29.7 0.1 0.002 18.4 0.1 2.8 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29182.1 - 0.0097 15.3 0.0 0.026 13.8 0.0 1.7 2 1 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETO29182.1 - 0.016 15.1 0.0 0.025 14.5 0.0 1.3 1 1 0 1 1 1 0 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO29182.1 - 0.028 14.4 0.1 7.9 6.6 0.0 2.7 1 1 1 2 2 2 0 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO29182.1 - 0.047 12.7 0.0 0.13 11.2 0.0 1.7 1 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Acyl-CoA_dh_1 PF00441.24 ETO29183.1 - 1.7e-36 125.7 0.9 2.4e-36 125.2 0.9 1.2 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_N PF02771.16 ETO29183.1 - 1e-12 48.7 0.0 1.3e-11 45.1 0.0 2.4 2 0 0 2 2 2 1 Acyl-CoA dehydrogenase, N-terminal domain Acyl-CoA_dh_2 PF08028.11 ETO29183.1 - 1.1e-09 38.7 0.6 1.7e-09 38.1 0.6 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain Acyl-CoA_dh_M PF02770.19 ETO29183.1 - 0.016 15.4 0.0 0.044 14.0 0.0 1.9 1 1 0 1 1 1 0 Acyl-CoA dehydrogenase, middle domain Arm PF00514.23 ETO29184.1 - 4.2e-05 23.4 4.4 45 4.3 0.0 7.6 7 0 0 7 7 7 2 Armadillo/beta-catenin-like repeat Atx10homo_assoc PF09759.9 ETO29184.1 - 0.00027 20.9 14.2 0.002 18.1 2.4 5.3 5 0 0 5 5 5 1 Spinocerebellar ataxia type 10 protein domain DUF3361 PF11841.8 ETO29184.1 - 0.72 9.8 10.5 1.3 8.9 0.0 5.1 5 1 0 5 5 5 0 Domain of unknown function (DUF3361) CBF PF03914.17 ETO29188.1 - 0.41 10.7 5.0 27 4.7 0.0 3.0 2 0 0 2 2 2 0 CBF/Mak21 family CDC27 PF09507.10 ETO29188.1 - 1.7 8.0 35.0 0.037 13.4 15.8 2.3 2 0 0 2 2 2 0 DNA polymerase subunit Cdc27 CDC45 PF02724.14 ETO29188.1 - 9.7 4.3 37.1 0.0089 14.4 14.9 2.5 2 0 0 2 2 2 0 CDC45-like protein EF-hand_7 PF13499.6 ETO29189.1 - 8.4e-14 51.8 9.6 9.1e-11 42.1 3.1 3.7 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO29189.1 - 1e-11 43.8 3.7 0.013 15.4 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_1 PF00036.32 ETO29189.1 - 6.8e-11 40.9 9.6 0.00018 20.8 0.1 4.5 4 0 0 4 4 4 3 EF hand EF-hand_5 PF13202.6 ETO29189.1 - 3.4e-08 32.6 0.9 0.13 11.8 0.0 3.9 3 0 0 3 3 3 3 EF hand SPARC_Ca_bdg PF10591.9 ETO29189.1 - 4.6e-05 23.7 11.3 0.0011 19.2 4.5 3.8 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 ETO29189.1 - 0.00026 20.8 7.6 0.0035 17.2 1.2 3.8 1 1 3 4 4 4 2 EF-hand domain pair DUF1007 PF06226.13 ETO29189.1 - 0.013 15.5 0.2 0.041 13.8 0.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1007) SpoVIF PF14069.6 ETO29189.1 - 0.023 14.4 0.4 0.058 13.2 0.0 1.8 2 0 0 2 2 2 0 Stage VI sporulation protein F TetR_C_37 PF18665.1 ETO29190.1 - 0.11 13.1 1.0 0.3 11.7 0.1 2.1 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain WW PF00397.26 ETO29190.1 - 0.12 12.5 0.5 0.58 10.3 0.5 2.2 1 0 0 1 1 1 0 WW domain IL15 PF02372.15 ETO29191.1 - 0.0048 16.9 0.3 0.0073 16.3 0.3 1.3 1 0 0 1 1 1 1 Interleukin 15 DENN PF02141.21 ETO29192.1 - 4.1e-27 95.4 1.5 4.1e-27 95.4 1.5 1.6 2 0 0 2 2 2 1 DENN (AEX-3) domain dDENN PF03455.19 ETO29192.1 - 1.6e-15 56.8 6.6 1.8e-15 56.7 1.2 2.7 2 0 0 2 2 2 1 dDENN domain SPA PF08616.10 ETO29192.1 - 0.073 13.0 0.1 0.22 11.5 0.1 1.9 1 0 0 1 1 1 0 Stabilization of polarity axis SR-25 PF10500.9 ETO29192.1 - 0.17 11.5 12.2 0.24 11.0 12.2 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF3915 PF13054.6 ETO29192.1 - 1.4 8.9 7.3 1.6 8.7 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Mito_carr PF00153.27 ETO29193.1 - 2.5e-15 56.2 0.0 2.8e-15 56.0 0.0 1.0 1 0 0 1 1 1 1 Mitochondrial carrier protein WD40 PF00400.32 ETO29194.1 - 3.5e-97 315.6 41.9 1.1e-11 45.1 0.2 12.2 12 0 0 12 12 12 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29194.1 - 1.9e-38 130.6 3.2 4.8e-05 23.6 0.0 10.7 1 1 9 10 10 10 10 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29194.1 - 4e-18 65.8 4.8 0.00048 19.6 0.3 5.6 3 1 3 6 6 6 6 WD40-like domain eIF2A PF08662.11 ETO29194.1 - 2.6e-17 63.4 0.0 2e-05 24.6 0.0 5.1 1 1 6 7 7 7 6 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO29194.1 - 1.7e-14 53.5 2.9 0.03 13.3 0.0 8.7 1 1 8 10 10 10 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO29194.1 - 2.3e-09 36.5 12.0 0.46 9.1 0.0 8.4 1 1 3 9 9 9 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO29194.1 - 1e-06 28.5 15.8 1.5 8.8 0.1 8.5 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat DUF727 PF05303.12 ETO29194.1 - 1.7e-06 28.0 0.2 1.2 9.2 0.0 5.6 3 3 3 6 6 6 2 Protein of unknown function (DUF727) Frtz PF11768.8 ETO29194.1 - 2.4e-06 26.2 0.1 0.84 7.9 0.0 5.0 2 2 3 6 6 6 5 WD repeat-containing and planar cell polarity effector protein Fritz TolB_N PF04052.13 ETO29194.1 - 0.00012 22.2 0.0 32 4.8 0.0 7.2 8 0 0 8 8 8 0 TolB amino-terminal domain DUF3475 PF11961.8 ETO29194.1 - 0.0026 17.8 1.7 74 3.5 0.0 5.8 6 1 1 7 7 7 0 Domain of unknown function (DUF3475) Proteasome_A_N PF10584.9 ETO29194.1 - 0.56 9.9 18.7 29 4.5 0.0 7.5 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature Helicase_C PF00271.31 ETO29195.1 - 3.3e-13 50.0 0.3 1.8e-12 47.6 0.0 2.1 1 1 1 2 2 2 1 Helicase conserved C-terminal domain LCD1 PF09798.9 ETO29195.1 - 0.0088 14.6 3.6 0.012 14.2 3.6 1.2 1 0 0 1 1 1 1 DNA damage checkpoint protein Sox_N PF12444.8 ETO29195.1 - 0.019 16.1 1.8 0.048 14.8 1.8 1.6 1 0 0 1 1 1 0 Sox developmental protein N terminal DUF4471 PF14740.6 ETO29195.1 - 0.13 11.5 3.5 0.21 10.8 3.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4471) RGS PF00615.19 ETO29196.1 - 1.5e-05 25.2 2.7 2.5e-05 24.5 2.7 1.4 1 0 0 1 1 1 1 Regulator of G protein signaling domain Ctr PF04145.15 ETO29197.1 - 0.35 11.5 10.2 6.4 7.4 10.2 2.2 1 1 0 1 1 1 0 Ctr copper transporter family PAP1 PF08601.10 ETO29197.1 - 7.2 6.2 21.0 9.4 5.9 21.0 1.1 1 0 0 1 1 1 0 Transcription factor PAP1 Vta1 PF04652.16 ETO29198.1 - 3.9e-25 88.5 2.4 9.3e-25 87.3 2.4 1.7 1 0 0 1 1 1 1 Vta1 like Vta1_C PF18097.1 ETO29198.1 - 6.4e-12 45.0 0.6 1.3e-11 44.0 0.6 1.5 1 0 0 1 1 1 1 Vta1 C-terminal domain Secretin_N_2 PF07655.13 ETO29200.1 - 0.0022 18.5 12.2 0.0022 18.5 12.2 1.7 2 0 0 2 2 2 1 Secretin N-terminal domain BTB_2 PF02214.22 ETO29200.1 - 0.0067 16.7 1.2 4.9 7.6 0.0 2.8 2 1 1 3 3 3 2 BTB/POZ domain Rad60-SLD PF11976.8 ETO29201.1 - 0.0025 17.6 0.1 0.0072 16.1 0.1 1.8 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like HNH PF01844.23 ETO29202.1 - 0.033 14.4 1.4 0.064 13.4 1.4 1.6 1 0 0 1 1 1 0 HNH endonuclease MgsA_C PF12002.8 ETO29202.1 - 0.093 12.7 4.0 0.092 12.7 2.9 1.5 1 1 0 1 1 1 0 MgsA AAA+ ATPase C terminal PA26 PF04636.13 ETO29202.1 - 1.6 7.5 11.4 1.9 7.3 11.4 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) SLC12 PF03522.15 ETO29202.1 - 4.9 6.1 16.9 5.9 5.8 16.9 1.0 1 0 0 1 1 1 0 Solute carrier family 12 LCD1 PF09798.9 ETO29202.1 - 6.7 5.1 18.0 8.1 4.8 18.0 1.1 1 0 0 1 1 1 0 DNA damage checkpoint protein Ndc1_Nup PF09531.10 ETO29202.1 - 7 5.2 9.2 8 5.0 9.2 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Membralin PF09746.9 ETO29202.1 - 8.4 5.3 13.8 10 5.0 13.8 1.0 1 0 0 1 1 1 0 Tumour-associated protein Kelch_2 PF07646.15 ETO29203.1 - 0.002 18.0 3.1 4.7 7.3 0.1 4.3 3 1 1 4 4 4 2 Kelch motif DUF3456 PF11938.8 ETO29205.1 - 0.0076 16.8 5.9 0.0076 16.8 5.9 1.4 1 1 0 1 1 1 1 TLR4 regulator and MIR-interacting MSAP Hrs_helical PF12210.8 ETO29205.1 - 0.032 14.7 0.1 2.9 8.5 0.0 2.5 2 0 0 2 2 2 0 Hepatocyte growth factor-regulated tyrosine kinase substrate Colicin PF01024.19 ETO29205.1 - 0.069 13.0 1.9 0.11 12.4 0.3 1.9 1 1 1 2 2 2 0 Colicin pore forming domain Herpes_UL31 PF02718.14 ETO29206.1 - 0.12 11.4 0.1 0.12 11.4 0.1 1.6 2 0 0 2 2 2 0 Herpesvirus UL31-like protein Ras PF00071.22 ETO29207.1 - 7.8e-21 74.3 0.0 9.9e-21 74.0 0.0 1.2 1 0 0 1 1 1 1 Ras family Arf PF00025.21 ETO29207.1 - 1.3e-05 24.7 0.0 1.5e-05 24.5 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO29207.1 - 2.1e-05 24.7 0.0 4.2e-05 23.7 0.0 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase MeaB PF03308.16 ETO29207.1 - 0.1 11.5 0.0 0.13 11.2 0.0 1.1 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB RsgA_GTPase PF03193.16 ETO29207.1 - 0.12 12.3 0.0 0.13 12.2 0.0 1.2 1 0 0 1 1 1 0 RsgA GTPase HAD_SAK_2 PF18143.1 ETO29208.1 - 1.8e-17 63.9 1.5 8.2e-17 61.8 1.5 1.8 1 1 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins tRNA-synt_1f PF01921.18 ETO29208.1 - 0.064 12.2 0.1 0.11 11.4 0.1 1.3 1 0 0 1 1 1 0 tRNA synthetases class I (K) ZIP4_domain PF18292.1 ETO29211.1 - 0.0067 16.4 0.7 0.033 14.1 0.1 2.2 2 0 0 2 2 2 1 Zinc transporter ZIP4 domain Molybdopterin_N PF18364.1 ETO29212.1 - 0.12 12.4 0.0 1.8 8.6 0.0 2.2 2 0 0 2 2 2 0 Molybdopterin oxidoreductase N-terminal domain RVT_1 PF00078.27 ETO29214.1 - 4.8e-12 45.9 0.4 4.3e-11 42.8 0.0 2.3 2 1 1 3 3 3 1 Reverse transcriptase (RNA-dependent DNA polymerase) PUB PF09409.10 ETO29215.1 - 0.00038 20.3 0.1 0.00038 20.3 0.1 2.9 2 1 1 3 3 3 1 PUB domain ART PF01129.18 ETO29215.1 - 0.00043 19.7 0.0 0.00085 18.7 0.0 1.5 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase HEPN_RES_NTD1 PF18870.1 ETO29215.1 - 0.082 13.1 14.8 0.03 14.5 8.4 3.2 2 2 0 2 2 2 0 HEPN/RES N-terminal domain 1 NDK PF00334.19 ETO29216.1 - 7.4e-25 87.5 0.0 1e-24 87.1 0.0 1.2 1 0 0 1 1 1 1 Nucleoside diphosphate kinase SMYLE_N PF18615.1 ETO29217.1 - 4.6 6.7 15.2 6.2 6.3 15.2 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain TLP-20 PF06088.11 ETO29217.1 - 8 6.3 15.8 2.5 7.9 5.6 2.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CAF1 PF04857.20 ETO29218.1 - 2.9e-15 56.2 18.0 6.9e-10 38.6 0.0 4.2 3 2 1 4 4 4 3 CAF1 family ribonuclease Macoilin PF09726.9 ETO29218.1 - 0.14 10.7 15.2 0.17 10.4 15.2 1.2 1 0 0 1 1 1 0 Macoilin family GTA_holin_3TM PF11351.8 ETO29220.1 - 7.7 7.1 6.5 2.7 8.6 1.0 2.8 3 0 0 3 3 3 0 Holin of 3TMs, for gene-transfer release HECT_2 PF09814.9 ETO29221.1 - 1.8e-13 50.1 5.7 2.3e-13 49.8 5.7 1.1 1 0 0 1 1 1 1 HECT-like Ubiquitin-conjugating enzyme (E2)-binding zf-BED PF02892.15 ETO29221.1 - 0.0031 17.5 0.6 0.012 15.6 0.0 2.2 2 0 0 2 2 2 1 BED zinc finger Chordopox_RPO7 PF05864.12 ETO29221.1 - 0.024 14.9 1.9 2.5 8.4 0.0 3.2 3 0 0 3 3 3 0 Chordopoxvirus DNA-directed RNA polymerase 7 kDa polypeptide (RPO7) TF_Zn_Ribbon PF08271.12 ETO29221.1 - 0.86 9.2 4.4 1.6 8.3 0.2 2.5 2 0 0 2 2 2 0 TFIIB zinc-binding zinc_ribbon_2 PF13240.6 ETO29221.1 - 9.5 6.1 8.0 38 4.2 0.1 3.8 4 0 0 4 4 4 0 zinc-ribbon domain Holin_BhlA PF10960.8 ETO29222.1 - 0.0089 16.0 0.1 0.018 15.0 0.1 1.5 1 0 0 1 1 1 1 BhlA holin family FUSC_2 PF13515.6 ETO29222.1 - 0.032 14.4 0.3 0.053 13.6 0.3 1.3 1 0 0 1 1 1 0 Fusaric acid resistance protein-like Fumarate_red_C PF02300.17 ETO29222.1 - 0.19 11.8 1.3 0.35 11.0 1.3 1.4 1 0 0 1 1 1 0 Fumarate reductase subunit C Eapp_C PF10238.9 ETO29223.1 - 3.3 7.8 12.9 3.9 7.5 6.1 3.4 2 0 0 2 2 2 0 E2F-associated phosphoprotein Pkinase_Tyr PF07714.17 ETO29225.1 - 3.3e-71 239.6 0.0 4.1e-71 239.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO29225.1 - 3.1e-55 187.4 0.0 4.2e-55 187.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO29225.1 - 2.3e-06 26.6 0.0 4e-06 25.9 0.0 1.3 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO29225.1 - 0.00081 18.8 0.1 0.0013 18.1 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO29225.1 - 0.013 15.0 0.0 0.09 12.3 0.0 2.1 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL Qua1 PF16274.5 ETO29225.1 - 0.044 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 Qua1 domain DUF3485 PF11984.8 ETO29226.1 - 0.0075 16.0 0.1 0.6 9.8 0.0 2.2 2 0 0 2 2 2 2 Protein of unknown function (DUF3485) SOG2 PF10428.9 ETO29227.1 - 0.0015 17.9 13.3 0.002 17.4 13.3 1.1 1 0 0 1 1 1 1 RAM signalling pathway protein DUF4094 PF13334.6 ETO29227.1 - 0.019 15.4 0.5 0.019 15.4 0.5 3.9 3 2 0 3 3 3 0 Domain of unknown function (DUF4094) SUR7 PF06687.12 ETO29227.1 - 0.55 9.8 0.0 0.55 9.8 0.0 2.7 2 1 0 2 2 2 0 SUR7/PalI family Menin PF05053.13 ETO29227.1 - 1 7.6 28.4 1.6 7.0 28.4 1.2 1 0 0 1 1 1 0 Menin Ctr PF04145.15 ETO29227.1 - 2.6 8.7 17.9 22 5.6 0.2 3.9 1 1 1 2 2 2 0 Ctr copper transporter family PfkB PF00294.24 ETO29228.1 - 0.042 13.2 1.2 2.7 7.2 0.1 2.2 1 1 1 2 2 2 0 pfkB family carbohydrate kinase GA PF01468.17 ETO29228.1 - 0.17 12.2 3.1 0.82 10.0 3.1 2.2 1 0 0 1 1 1 0 GA module DUF2457 PF10446.9 ETO29230.1 - 6.5e-05 22.3 13.0 0.00011 21.6 13.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO29230.1 - 0.012 13.9 11.1 0.016 13.5 11.1 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO29230.1 - 0.02 13.2 12.3 0.027 12.8 12.3 1.1 1 0 0 1 1 1 0 CDC45-like protein RPOL_N PF14700.6 ETO29230.1 - 0.07 12.5 1.3 0.13 11.7 1.3 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase N-terminal DAG_kinase_N PF14513.6 ETO29230.1 - 0.16 12.1 6.3 0.36 11.0 6.3 1.5 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus Tim54 PF11711.8 ETO29230.1 - 0.21 10.3 4.6 0.4 9.4 4.6 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 ETO29230.1 - 0.27 10.0 15.4 0.4 9.4 15.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 ETO29230.1 - 0.83 8.6 11.2 1.4 7.9 11.2 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ETO29230.1 - 1.2 7.9 13.2 2.2 7.0 13.2 1.3 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO29230.1 - 1.3 7.8 5.9 1.8 7.3 5.9 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RNA_pol_Rpc4 PF05132.14 ETO29230.1 - 2.2 8.7 5.3 4.5 7.7 5.3 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Zip PF02535.22 ETO29230.1 - 6.7 5.8 12.4 0.17 11.0 5.6 1.8 2 0 0 2 2 2 0 ZIP Zinc transporter DNA_pol_phi PF04931.13 ETO29230.1 - 7.2 4.6 18.1 10 4.1 18.1 1.1 1 0 0 1 1 1 0 DNA polymerase phi UAA PF08449.11 ETO29232.1 - 1.9e-22 79.9 3.7 2.2e-22 79.7 3.7 1.0 1 0 0 1 1 1 1 UAA transporter family EamA PF00892.20 ETO29232.1 - 4.4e-05 23.7 0.3 4.4e-05 23.7 0.3 2.7 2 1 1 3 3 3 1 EamA-like transporter family TMEM107 PF14995.6 ETO29232.1 - 0.015 15.8 0.7 0.015 15.8 0.7 1.9 1 1 0 2 2 2 0 Transmembrane protein DUF3098 PF11297.8 ETO29232.1 - 0.056 13.0 0.2 0.15 11.7 0.2 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3098) DUF3040 PF11239.8 ETO29232.1 - 0.59 10.4 1.9 0.45 10.8 0.2 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) MbeD_MobD PF04899.12 ETO29233.1 - 1 9.5 10.8 0.92 9.7 7.3 2.9 2 0 0 2 2 2 0 MbeD/MobD like BUD22 PF09073.10 ETO29233.1 - 5.5 6.2 58.1 0.0091 15.4 28.4 3.6 3 0 0 3 3 3 0 BUD22 Pyr_redox_2 PF07992.14 ETO29234.1 - 1.1e-11 44.6 1.4 6.9e-11 41.9 1.4 1.9 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO29234.1 - 1.7e-06 28.5 0.1 3.3e-06 27.6 0.1 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO29234.1 - 0.009 15.2 0.0 0.014 14.5 0.0 1.3 1 0 0 1 1 1 1 L-lysine 6-monooxygenase (NADPH-requiring) DEFB136 PF17333.2 ETO29235.1 - 0.14 12.1 2.9 9 6.3 0.1 2.4 2 0 0 2 2 2 0 Beta defensin 136 CDP-OH_P_transf PF01066.21 ETO29236.1 - 1.3e-11 45.1 0.8 1.3e-11 45.1 0.8 2.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase Caldesmon PF02029.15 ETO29237.1 - 8.6 5.0 63.1 1.8 7.2 43.4 2.1 2 0 0 2 2 2 0 Caldesmon Frtz PF11768.8 ETO29239.1 - 0.00012 20.6 0.2 0.002 16.5 0.0 2.2 1 1 1 2 2 2 2 WD repeat-containing and planar cell polarity effector protein Fritz Orf78 PF06024.12 ETO29239.1 - 1 9.7 3.5 0.71 10.2 0.1 2.4 3 0 0 3 3 3 0 Orf78 (ac78) DUF3670 PF12419.8 ETO29241.1 - 0.026 14.4 0.0 0.16 11.8 0.0 1.9 1 1 0 1 1 1 0 SNF2 Helicase protein Imm70 PF15601.6 ETO29241.1 - 0.041 13.4 0.3 6.5 6.3 0.1 2.3 2 0 0 2 2 2 0 Immunity protein 70 PSII_Pbs27 PF13326.6 ETO29241.1 - 0.1 12.9 0.0 0.13 12.6 0.0 1.5 1 1 0 1 1 1 0 Photosystem II Pbs27 Dsh_C PF12316.8 ETO29243.1 - 0.46 10.9 9.3 0.45 10.9 9.3 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal AAA PF00004.29 ETO29244.1 - 0.13 12.7 0.0 0.28 11.6 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) HA2 PF04408.23 ETO29245.1 - 1.5e-17 63.8 0.0 4.4e-17 62.3 0.0 1.8 1 1 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETO29245.1 - 1.4e-11 44.8 0.1 3.9e-11 43.3 0.0 1.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain Exo_endo_phos_2 PF14529.6 ETO29246.1 - 5.9e-08 32.6 0.1 7.4e-08 32.3 0.1 1.1 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase LTD PF00932.19 ETO29247.1 - 0.12 12.8 0.1 0.17 12.3 0.1 1.3 1 0 0 1 1 1 0 Lamin Tail Domain DEAD PF00270.29 ETO29249.1 - 1.1e-10 41.6 0.6 9.1e-10 38.6 0.6 2.1 1 1 0 1 1 1 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO29249.1 - 7.6e-07 29.5 0.3 1.7e-06 28.3 0.3 1.6 1 1 0 1 1 1 1 AAA domain DUF2075 PF09848.9 ETO29249.1 - 2.1e-05 24.0 0.6 3.8e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Uncharacterized conserved protein (DUF2075) T2SSE PF00437.20 ETO29249.1 - 0.00059 19.0 0.0 0.001 18.2 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein HU-CCDC81_bac_1 PF18174.1 ETO29249.1 - 0.003 17.4 0.9 0.37 10.7 0.1 2.4 2 0 0 2 2 2 1 CCDC81-like prokaryotic HU domain 1 AAA_19 PF13245.6 ETO29249.1 - 0.0031 17.9 0.0 0.0059 16.9 0.0 1.5 1 1 0 1 1 1 1 AAA domain ResIII PF04851.15 ETO29249.1 - 0.004 17.2 0.1 0.29 11.1 0.0 2.3 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_30 PF13604.6 ETO29249.1 - 0.0041 16.8 0.0 0.0063 16.2 0.0 1.2 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 ETO29249.1 - 0.0062 15.8 0.0 0.015 14.5 0.0 1.6 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 AAA_29 PF13555.6 ETO29249.1 - 0.0076 16.0 0.2 0.027 14.2 0.0 2.0 2 0 0 2 2 2 1 P-loop containing region of AAA domain AAA_14 PF13173.6 ETO29249.1 - 0.011 15.8 0.1 6.1 6.9 0.0 2.7 1 1 1 2 2 2 0 AAA domain ATPase PF06745.13 ETO29249.1 - 0.019 14.3 0.0 0.041 13.2 0.0 1.6 2 0 0 2 2 2 0 KaiC Microtub_bd PF16796.5 ETO29249.1 - 0.029 14.3 0.1 0.061 13.3 0.1 1.5 1 0 0 1 1 1 0 Microtubule binding AAA_16 PF13191.6 ETO29249.1 - 0.04 14.3 1.5 0.059 13.8 0.3 2.0 2 1 0 2 2 2 0 AAA ATPase domain Helicase_RecD PF05127.14 ETO29249.1 - 0.049 13.5 0.1 0.1 12.4 0.0 1.7 2 0 0 2 2 1 0 Helicase AAA_23 PF13476.6 ETO29249.1 - 0.059 13.9 0.2 0.059 13.9 0.2 2.2 1 1 1 2 2 2 0 AAA domain PhoH PF02562.16 ETO29249.1 - 0.067 12.6 0.1 0.15 11.5 0.0 1.6 2 0 0 2 2 2 0 PhoH-like protein Rhodanese PF00581.20 ETO29249.1 - 0.071 13.6 0.0 0.15 12.5 0.0 1.5 1 1 0 1 1 1 0 Rhodanese-like domain FtsK_SpoIIIE PF01580.18 ETO29249.1 - 0.074 12.4 0.0 0.11 11.9 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_7 PF12775.7 ETO29249.1 - 0.09 12.3 0.1 0.22 11.0 0.0 1.6 2 0 0 2 2 2 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 ETO29249.1 - 0.11 12.1 0.1 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 Sigma-54 interaction domain ABC_tran PF00005.27 ETO29249.1 - 0.56 10.7 2.9 0.64 10.5 0.2 2.3 2 1 1 3 3 3 0 ABC transporter HEV_ORF1 PF02444.16 ETO29250.1 - 8 7.1 5.5 0.76 10.4 0.6 1.8 2 0 0 2 2 2 0 Hepatitis E virus ORF-2 (Putative capsid protein) VWA PF00092.28 ETO29251.1 - 8.1e-12 45.7 0.0 1.1e-11 45.3 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO29251.1 - 7.5e-10 39.0 0.0 9.5e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO29251.1 - 1.6e-09 38.3 0.0 2.5e-09 37.8 0.0 1.2 1 0 0 1 1 1 1 von Willebrand factor type A domain Copine PF07002.16 ETO29251.1 - 9e-05 22.0 0.0 0.00012 21.7 0.0 1.1 1 0 0 1 1 1 1 Copine VWA_CoxE PF05762.14 ETO29251.1 - 0.063 12.7 0.0 0.11 11.9 0.0 1.3 1 1 0 1 1 1 0 VWA domain containing CoxE-like protein vWA-TerF-like PF10138.9 ETO29251.1 - 0.084 13.0 0.0 0.15 12.2 0.0 1.4 1 1 0 1 1 1 0 vWA found in TerF C terminus DUF4378 PF14309.6 ETO29253.1 - 0.00098 19.5 1.2 0.0012 19.3 1.2 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4378) Il13Ra_Ig PF18001.1 ETO29253.1 - 0.014 15.5 1.1 0.023 14.8 1.1 1.4 1 0 0 1 1 1 0 Interleukin-13 receptor subunit alpha Ig-like domain DUF1120 PF06551.12 ETO29253.1 - 0.071 13.3 0.4 0.12 12.6 0.3 1.3 1 1 0 1 1 1 0 Protein of unknown function (DUF1120) Mog1 PF04603.12 ETO29253.1 - 5.9 7.3 7.0 13 6.2 7.0 1.7 1 1 0 1 1 1 0 Ran-interacting Mog1 protein RGS PF00615.19 ETO29255.1 - 5.7e-10 39.5 0.1 2.1e-09 37.6 0.1 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain DUF1803 PF08820.10 ETO29255.1 - 2.6 8.1 6.7 9.3 6.4 0.7 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1803) NESP55 PF06390.12 ETO29256.1 - 0.0029 17.3 0.2 0.0043 16.7 0.2 1.4 1 0 0 1 1 1 1 Neuroendocrine-specific golgi protein P55 (NESP55) Stealth_CR3 PF17102.5 ETO29257.1 - 0.038 13.9 0.3 0.038 13.9 0.3 1.9 2 0 0 2 2 2 0 Stealth protein CR3, conserved region 3 DUF5345 PF17280.2 ETO29257.1 - 0.094 12.7 0.2 0.23 11.5 0.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5345) Axin_b-cat_bind PF08833.10 ETO29257.1 - 0.18 11.9 0.5 1.3 9.2 0.2 2.3 2 0 0 2 2 2 0 Axin beta-catenin binding domain PH PF00169.29 ETO29258.1 - 0.00011 22.6 4.4 0.00066 20.2 0.1 2.9 2 1 1 3 3 3 1 PH domain DUF885 PF05960.11 ETO29260.1 - 0.002 17.9 1.5 0.0024 17.6 1.5 1.1 1 0 0 1 1 1 1 Bacterial protein of unknown function (DUF885) SAM_1 PF00536.30 ETO29260.1 - 0.029 14.8 0.1 0.099 13.1 0.1 2.0 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF2383 PF09537.10 ETO29260.1 - 1.4 9.3 7.0 0.23 11.8 2.3 2.1 2 1 0 2 2 2 0 Domain of unknown function (DUF2383) Actin PF00022.19 ETO29261.1 - 1.1e-80 271.3 0.0 7.1e-80 268.6 0.0 1.8 1 1 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO29261.1 - 0.23 10.3 0.0 0.36 9.6 0.0 1.2 1 0 0 1 1 1 0 MreB/Mbl protein TMEM125 PF15109.6 ETO29262.1 - 0.0034 17.7 1.3 0.0066 16.8 1.3 1.4 1 0 0 1 1 1 1 TMEM125 protein family DUF2371 PF10177.9 ETO29262.1 - 0.19 11.9 2.0 2.4 8.3 0.0 2.9 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) 7tm_3 PF00003.22 ETO29262.1 - 4.2 7.0 19.9 0.19 11.5 9.9 2.6 1 1 2 3 3 3 0 7 transmembrane sweet-taste receptor of 3 GCPR RGS PF00615.19 ETO29263.1 - 5.5e-05 23.4 3.0 0.056 13.7 2.3 3.6 2 1 0 2 2 2 1 Regulator of G protein signaling domain DUF2663 PF10864.8 ETO29263.1 - 0.057 13.8 2.1 0.28 11.6 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) Pex24p PF06398.11 ETO29263.1 - 0.16 10.9 0.0 0.16 10.9 0.0 1.7 2 0 0 2 2 2 0 Integral peroxisomal membrane peroxin DUF2207 PF09972.9 ETO29263.1 - 1.4 7.6 5.2 1.9 7.1 5.2 1.4 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Brr6_like_C_C PF10104.9 ETO29263.1 - 2.5 7.9 5.2 0.18 11.5 0.2 1.7 2 0 0 2 2 2 0 Di-sulfide bridge nucleocytoplasmic transport domain Mannosyl_trans3 PF11051.8 ETO29264.1 - 1.6e-17 63.8 0.1 2.9e-17 62.9 0.1 1.4 1 0 0 1 1 1 1 Mannosyltransferase putative Nucleotid_trans PF03407.16 ETO29264.1 - 0.023 14.6 0.5 0.051 13.5 0.1 1.8 2 0 0 2 2 2 0 Nucleotide-diphospho-sugar transferase Med28 PF11594.8 ETO29264.1 - 0.048 13.8 0.2 2.5 8.2 0.0 2.7 2 0 0 2 2 2 0 Mediator complex subunit 28 Pho88 PF10032.9 ETO29264.1 - 0.082 12.2 0.8 0.18 11.1 0.8 1.6 1 0 0 1 1 1 0 Phosphate transport (Pho88) Kelch_5 PF13854.6 ETO29265.1 - 0.0078 16.2 0.3 17 5.6 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO29265.1 - 0.12 12.7 0.5 46 4.5 0.2 3.7 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO29266.1 - 2.4e-39 132.6 5.2 1.1e-08 35.5 0.0 5.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29266.1 - 7.7e-13 48.6 0.3 0.096 13.0 0.1 5.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29266.1 - 9.5e-10 37.9 0.7 0.0077 15.2 0.0 4.0 2 1 2 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO29266.1 - 0.0039 15.8 1.7 0.58 8.6 0.1 3.1 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO29266.1 - 0.0055 16.1 0.3 3.4 6.9 0.0 2.7 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO29266.1 - 0.006 15.3 0.6 6.7 5.2 0.0 3.9 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Proteasome_A_N PF10584.9 ETO29266.1 - 0.072 12.8 0.3 0.58 9.9 0.0 2.6 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature HARP PF07443.13 ETO29266.1 - 0.09 12.4 0.0 4.6 7.0 0.0 2.9 2 0 0 2 2 2 0 HepA-related protein (HARP) Methyltransf_3 PF01596.17 ETO29266.1 - 0.096 11.8 0.0 0.17 11.1 0.0 1.4 1 0 0 1 1 1 0 O-methyltransferase Tubulin PF00091.25 ETO29267.1 - 2.3e-50 171.6 0.4 4.7e-50 170.5 0.4 1.6 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO29267.1 - 8.1e-35 119.7 0.3 2.6e-34 118.1 0.3 1.9 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin_3 PF14881.6 ETO29267.1 - 0.027 14.1 1.0 1.1 8.9 0.0 2.3 2 0 0 2 2 2 0 Tubulin domain Tubulin_2 PF13809.6 ETO29267.1 - 0.064 12.4 0.1 0.18 11.0 0.0 1.7 2 0 0 2 2 2 0 Tubulin like Tubulin PF00091.25 ETO29268.1 - 7.7e-52 176.4 0.1 4.4e-25 89.0 0.0 2.5 1 1 1 2 2 2 2 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO29268.1 - 7.6e-18 64.9 1.0 1.4e-17 64.0 0.1 2.0 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO29268.1 - 0.00082 19.7 2.9 0.0014 18.9 0.0 2.8 3 1 0 3 3 3 1 Misato Segment II tubulin-like domain G-alpha PF00503.20 ETO29269.1 - 3.6e-29 102.1 0.0 4.5e-29 101.7 0.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO29269.1 - 0.031 13.7 0.0 0.044 13.2 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family Glyco_hydro_114 PF03537.13 ETO29269.1 - 0.032 13.6 0.0 0.047 13.0 0.0 1.2 1 0 0 1 1 1 0 Glycoside-hydrolase family GH114 ABC_tran PF00005.27 ETO29269.1 - 0.035 14.6 0.0 0.057 13.9 0.0 1.3 1 0 0 1 1 1 0 ABC transporter AAA_18 PF13238.6 ETO29269.1 - 0.063 13.8 0.0 0.11 13.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain G-alpha PF00503.20 ETO29270.1 - 6.5e-14 51.9 7.5 3.5e-10 39.6 2.2 2.1 2 0 0 2 2 2 2 G-protein alpha subunit DUF2207 PF09972.9 ETO29270.1 - 0.13 11.0 4.8 0.15 10.8 4.8 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Questin_oxidase PF14027.6 ETO29270.1 - 1.5 8.3 6.9 1.2 8.6 1.1 2.0 2 0 0 2 2 2 0 Questin oxidase-like LMBR1 PF04791.16 ETO29271.1 - 0.0052 15.7 4.1 0.0061 15.5 4.1 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein DUF2207 PF09972.9 ETO29271.1 - 0.0067 15.3 4.7 0.0069 15.2 4.7 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) SUR7 PF06687.12 ETO29271.1 - 0.0078 15.9 5.6 0.0093 15.6 5.6 1.1 1 0 0 1 1 1 1 SUR7/PalI family Pex26 PF07163.12 ETO29271.1 - 0.026 13.8 0.6 0.029 13.7 0.6 1.1 1 0 0 1 1 1 0 Pex26 protein EMC3_TMCO1 PF01956.16 ETO29271.1 - 0.028 14.1 5.2 0.036 13.8 5.2 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Orf78 PF06024.12 ETO29271.1 - 0.038 14.3 0.3 0.065 13.5 0.3 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Shisa PF13908.6 ETO29271.1 - 0.083 13.1 0.2 0.11 12.7 0.2 1.1 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator CrgA PF06781.12 ETO29271.1 - 0.13 12.4 0.0 0.25 11.4 0.0 1.4 1 1 0 1 1 1 0 Cell division protein CrgA HSCB_C PF07743.13 ETO29272.1 - 6.3e-16 58.6 2.1 1.2e-15 57.7 2.1 1.5 1 0 0 1 1 1 1 HSCB C-terminal oligomerisation domain DnaJ PF00226.31 ETO29272.1 - 0.00051 20.1 0.8 0.001 19.1 0.8 1.6 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 ETO29273.1 - 2.1e-31 107.5 0.1 2.6e-14 52.8 0.0 2.5 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO29273.1 - 0.00063 19.3 0.0 0.043 13.4 0.0 2.6 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO29273.1 - 0.0016 18.5 0.1 0.28 11.3 0.0 2.6 2 0 0 2 2 2 1 RNA recognition motif DUF3439 PF11921.8 ETO29273.1 - 0.0024 17.8 2.8 0.0025 17.7 0.5 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF3439) Rad60-SLD PF11976.8 ETO29273.1 - 0.022 14.6 0.3 0.052 13.4 0.3 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like fn3 PF00041.21 ETO29274.1 - 9.8e-08 32.2 5.0 1.2e-05 25.6 0.0 3.7 3 0 0 3 3 3 2 Fibronectin type III domain DDE_Tnp_IS1595 PF12762.7 ETO29274.1 - 0.1 12.6 0.7 0.22 11.5 0.7 1.5 1 0 0 1 1 1 0 ISXO2-like transposase domain Ras PF00071.22 ETO29275.1 - 1.2e-27 96.4 1.0 8.6e-13 48.2 0.1 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO29275.1 - 2e-14 53.8 0.1 4.3e-09 36.6 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO29275.1 - 1.5e-06 28.3 0.1 2.5e-06 27.5 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase EptA_B_N PF08019.12 ETO29275.1 - 0.14 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 Phosphoethanolamine transferase EptA/EptB IF4E PF01652.18 ETO29276.1 - 4.8e-46 156.4 1.6 5.4e-46 156.3 1.6 1.0 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Ank_2 PF12796.7 ETO29277.1 - 9.1e-19 67.8 2.3 1.2e-10 41.8 0.2 2.2 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO29277.1 - 1.7e-16 60.0 0.1 1.1e-08 35.1 0.1 2.6 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO29277.1 - 1.2e-13 51.2 0.1 0.00029 21.3 0.0 3.5 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO29277.1 - 3.3e-11 43.1 0.1 0.0062 16.9 0.0 4.6 5 0 0 5 5 5 2 Ankyrin repeat Ank_3 PF13606.6 ETO29277.1 - 3.7e-09 36.1 0.2 0.1 13.2 0.0 4.3 5 1 0 5 5 5 2 Ankyrin repeat GH97_C PF14509.6 ETO29277.1 - 0.1 12.9 0.1 0.21 11.8 0.1 1.5 1 1 0 1 1 1 0 Glycosyl-hydrolase 97 C-terminal, oligomerisation Tctex-1 PF03645.13 ETO29280.1 - 8.7e-26 90.2 0.5 1e-25 89.9 0.5 1.1 1 0 0 1 1 1 1 Tctex-1 family MFS_1_like PF12832.7 ETO29282.1 - 1.5e-24 86.6 3.6 3.6e-14 52.4 4.0 2.2 2 0 0 2 2 2 2 MFS_1 like family MFS_1 PF07690.16 ETO29282.1 - 1.2e-11 44.1 1.1 1.6e-09 37.2 3.1 2.2 2 0 0 2 2 2 1 Major Facilitator Superfamily ATG22 PF11700.8 ETO29282.1 - 6.3e-06 25.1 0.5 1.3e-05 24.1 0.5 1.5 1 1 0 1 1 1 1 Vacuole effluxer Atg22 like Zip PF02535.22 ETO29282.1 - 8.7e-05 21.9 0.1 0.00015 21.1 0.1 1.5 1 0 0 1 1 1 1 ZIP Zinc transporter SUIM_assoc PF16619.5 ETO29282.1 - 0.00015 21.8 0.1 0.00015 21.8 0.1 2.7 2 0 0 2 2 2 1 Unstructured region C-term to UIM in Ataxin3 V_ATPase_I PF01496.19 ETO29282.1 - 0.00036 18.6 0.8 0.00036 18.6 0.8 1.5 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family YABBY PF04690.13 ETO29282.1 - 0.0021 18.6 3.4 0.0021 18.6 3.4 2.1 2 1 0 2 2 2 1 YABBY protein Neur_chan_memb PF02932.16 ETO29282.1 - 0.0025 17.9 0.4 0.014 15.4 0.0 2.0 2 0 0 2 2 2 1 Neurotransmitter-gated ion-channel transmembrane region G0-G1_switch_2 PF15103.6 ETO29282.1 - 0.0032 17.9 1.3 0.0032 17.9 1.3 3.3 1 1 2 3 3 3 1 G0/G1 switch protein 2 SelP_N PF04592.14 ETO29282.1 - 0.0071 15.8 11.7 0.013 14.9 11.7 1.4 1 0 0 1 1 1 1 Selenoprotein P, N terminal region DUF4407 PF14362.6 ETO29282.1 - 0.027 13.8 0.9 0.046 13.1 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) INSIG PF07281.12 ETO29282.1 - 0.045 13.4 0.0 1.4 8.5 0.0 2.5 2 0 0 2 2 2 0 Insulin-induced protein (INSIG) Mem_trans PF03547.18 ETO29282.1 - 0.12 10.8 5.8 0.044 12.2 2.7 1.6 1 1 0 2 2 2 0 Membrane transport protein CLN3 PF02487.17 ETO29282.1 - 0.18 10.8 4.1 0.34 9.9 4.1 1.4 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 ETO29282.1 - 0.25 9.7 5.1 0.3 9.4 3.9 1.5 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Ly49 PF08391.10 ETO29282.1 - 0.9 9.9 9.4 0.4 11.0 6.1 2.2 2 0 0 2 2 1 0 Ly49-like protein, N-terminal region FAM60A PF15396.6 ETO29282.1 - 1.6 8.6 10.6 0.14 12.2 4.9 1.9 2 0 0 2 2 2 0 Protein Family FAM60A Pannexin_like PF12534.8 ETO29282.1 - 2.3 7.2 10.5 0.26 10.4 5.7 1.8 2 0 0 2 2 2 0 Pannexin-like TM region of LRRC8 Folate_carrier PF01770.18 ETO29282.1 - 7.1 5.2 8.9 3.7 6.2 6.4 1.8 1 1 0 1 1 1 0 Reduced folate carrier TFIIA PF03153.13 ETO29282.1 - 9 6.2 28.1 0.64 9.9 16.3 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit COPIIcoated_ERV PF07970.12 ETO29283.1 - 5e-19 69.0 0.2 9.3e-19 68.2 0.2 1.4 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter Thioredoxin PF00085.20 ETO29283.1 - 1.5e-16 60.2 1.0 3.4e-09 36.6 0.2 2.8 3 0 0 3 3 3 2 Thioredoxin Thioredoxin_8 PF13905.6 ETO29283.1 - 0.00012 22.4 0.8 0.0095 16.2 0.0 3.4 3 0 0 3 3 3 1 Thioredoxin-like ERGIC_N PF13850.6 ETO29283.1 - 0.00019 21.7 0.2 0.00054 20.2 0.2 1.8 1 0 0 1 1 1 1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Thioredoxin_2 PF13098.6 ETO29283.1 - 0.033 14.6 1.4 0.081 13.4 0.1 2.3 3 1 0 3 3 3 0 Thioredoxin-like domain Apo-CIII PF05778.12 ETO29283.1 - 0.12 12.0 0.7 0.28 10.9 0.1 1.9 2 0 0 2 2 2 0 Apolipoprotein CIII (Apo-CIII) PI3K_rbd PF00794.18 ETO29284.1 - 0.00021 21.4 0.7 0.00062 19.9 0.7 1.8 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain SPRY PF00622.28 ETO29285.1 - 2.7e-24 85.6 0.2 1.5e-22 80.0 0.1 2.9 2 0 0 2 2 2 1 SPRY domain zf-RanBP PF00641.18 ETO29285.1 - 1.4e-06 27.5 9.5 6.2e-05 22.2 3.3 2.6 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others DZR PF12773.7 ETO29285.1 - 4.4 7.4 8.2 15 5.7 8.2 2.0 1 0 0 1 1 1 0 Double zinc ribbon CNDH2_M PF16869.5 ETO29286.1 - 0.088 13.5 3.5 0.17 12.6 3.5 1.5 1 1 0 1 1 1 0 PF16858 Zip PF02535.22 ETO29286.1 - 0.23 10.6 0.4 0.22 10.7 0.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO29286.1 - 1.9 7.2 7.8 2.4 6.9 7.8 1.2 1 0 0 1 1 1 0 Presenilin DUF4685 PF15737.5 ETO29287.1 - 1 9.8 6.3 0.23 11.9 1.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4685) LCD1 PF09798.9 ETO29288.1 - 0.091 11.3 6.4 0.097 11.2 6.4 1.2 1 0 0 1 1 1 0 DNA damage checkpoint protein CDC45 PF02724.14 ETO29288.1 - 2.2 6.5 11.3 2.3 6.4 11.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Hist_deacetyl PF00850.19 ETO29289.1 - 3e-55 187.8 0.2 4.3e-55 187.4 0.2 1.2 1 0 0 1 1 1 1 Histone deacetylase domain TUG-UBL1 PF11470.8 ETO29290.1 - 4.1e-07 30.1 0.0 9.7e-07 28.9 0.0 1.7 1 0 0 1 1 1 1 TUG ubiquitin-like domain Ufm1 PF03671.14 ETO29290.1 - 0.0048 17.0 0.0 0.014 15.5 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin fold modifier 1 protein PUA_2 PF14306.6 ETO29290.1 - 0.056 13.1 0.0 0.14 11.8 0.0 1.7 1 0 0 1 1 1 0 PUA-like domain FAD-SLDH PF12318.8 ETO29290.1 - 0.34 11.0 3.5 0.2 11.7 0.7 1.9 2 0 0 2 2 2 0 Membrane bound FAD containing D-sorbitol dehydrogenase VHS PF00790.19 ETO29291.1 - 2e-11 43.9 0.0 7e-06 25.9 0.0 2.1 2 0 0 2 2 2 2 VHS domain PP2C PF00481.21 ETO29292.1 - 1.8e-33 116.3 0.0 4.6e-32 111.7 0.0 2.1 1 1 0 1 1 1 1 Protein phosphatase 2C APG6_N PF17675.1 ETO29293.1 - 0.033 14.7 0.2 0.033 14.7 0.2 2.5 2 0 0 2 2 2 0 Apg6 coiled-coil region Mod_r PF07200.13 ETO29293.1 - 0.43 10.7 24.3 1 9.4 1.0 2.4 2 0 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein FlaC_arch PF05377.11 ETO29293.1 - 1.9 9.0 10.7 6.6 7.2 0.5 4.0 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) MCPsignal PF00015.21 ETO29293.1 - 7.2 6.4 12.1 2.2 8.0 6.1 2.7 2 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain Atg14 PF10186.9 ETO29293.1 - 7.7 5.5 26.4 4.8 6.2 8.4 2.6 1 1 2 3 3 3 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF948 PF06103.11 ETO29293.1 - 7.8 6.8 11.3 23 5.4 6.8 3.1 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) WD40 PF00400.32 ETO29294.1 - 1.1e-54 181.1 19.9 1.9e-09 38.0 0.5 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29294.1 - 1.1e-18 67.3 3.2 0.015 15.6 0.0 6.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29294.1 - 5.3e-10 38.8 0.8 0.06 12.3 0.1 4.6 1 1 2 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29294.1 - 1.9e-09 37.3 1.3 0.00019 20.9 0.1 4.0 1 1 3 4 4 4 2 WD40-like domain DUF5046 PF16465.5 ETO29294.1 - 0.00025 20.6 0.0 0.12 11.8 0.0 2.5 1 1 1 2 2 2 2 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 ETO29294.1 - 0.0003 19.5 0.5 0.079 11.5 0.0 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO29294.1 - 0.0039 17.3 2.3 6.2 6.9 0.2 4.3 1 1 3 5 5 5 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO29294.1 - 0.0055 15.5 4.8 2.3 6.8 0.1 3.5 1 1 1 3 3 3 2 Nup133 N terminal like Me-amine-dh_H PF06433.11 ETO29294.1 - 0.011 14.7 0.0 0.79 8.5 0.0 2.9 2 1 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO29294.1 - 0.24 11.4 4.8 1.1e+02 2.8 0.0 4.9 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat LRR_4 PF12799.7 ETO29296.1 - 8.7e-12 45.1 18.1 8.8e-07 29.2 1.7 3.3 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO29296.1 - 3.6e-06 26.6 14.0 2.2e-05 24.1 8.7 3.5 1 1 2 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 ETO29296.1 - 0.023 14.2 3.3 0.033 13.7 3.3 1.3 1 0 0 1 1 1 0 Leucine-rich repeat LRR_6 PF13516.6 ETO29296.1 - 0.16 12.1 9.0 5.7 7.3 0.2 3.8 3 0 0 3 3 3 0 Leucine Rich repeat LRR_1 PF00560.33 ETO29296.1 - 0.55 11.0 14.8 4 8.4 0.1 4.7 4 1 0 4 4 4 0 Leucine Rich Repeat Med3 PF11593.8 ETO29298.1 - 0.001 18.3 4.9 0.0014 17.9 4.9 1.2 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal SLX9 PF15341.6 ETO29298.1 - 0.0023 18.4 3.8 0.0027 18.1 3.8 1.2 1 0 0 1 1 1 1 Ribosome biogenesis protein SLX9 ADIP PF11559.8 ETO29298.1 - 0.022 14.8 5.4 0.031 14.4 5.4 1.2 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding RGS-like PF09128.11 ETO29298.1 - 0.084 12.6 2.7 0.11 12.2 2.2 1.3 1 1 0 1 1 1 0 Regulator of G protein signalling-like domain DUF3362 PF11842.8 ETO29298.1 - 0.28 11.5 6.9 0.47 10.8 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3362) XRCC4 PF06632.12 ETO29298.1 - 3.2 6.5 10.5 4.1 6.2 10.5 1.1 1 0 0 1 1 1 0 DNA double-strand break repair and V(D)J recombination protein XRCC4 Zip PF02535.22 ETO29298.1 - 3.3 6.8 4.4 3.8 6.7 4.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO29298.1 - 4.3 6.0 8.2 4.9 5.8 8.2 1.1 1 0 0 1 1 1 0 Presenilin SNARE PF05739.19 ETO29299.1 - 0.13 12.3 2.8 0.6 10.1 2.8 2.2 1 0 0 1 1 1 0 SNARE domain Shisa PF13908.6 ETO29299.1 - 5.7 7.1 11.4 0.73 10.1 0.2 2.9 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator Mito_fiss_reg PF05308.11 ETO29300.1 - 0.013 15.6 3.4 0.013 15.6 3.4 1.8 2 0 0 2 2 2 0 Mitochondrial fission regulator DUF4446 PF14584.6 ETO29300.1 - 0.063 13.3 0.4 0.14 12.2 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) Med9 PF07544.13 ETO29300.1 - 0.15 12.2 3.2 0.12 12.5 1.4 1.8 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 SlyX PF04102.12 ETO29300.1 - 0.25 12.0 1.5 0.51 11.0 1.5 1.4 1 0 0 1 1 1 0 SlyX DivIC PF04977.15 ETO29300.1 - 0.25 11.1 4.6 0.13 12.1 2.4 1.6 2 0 0 2 2 2 0 Septum formation initiator USP19_linker PF16602.5 ETO29300.1 - 0.93 10.1 3.0 1.5 9.4 0.0 2.6 2 2 2 4 4 4 0 Linker region of USP19 deubiquitinase ETRAMP PF09716.10 ETO29301.1 - 0.0032 17.5 4.1 1.2 9.3 0.0 4.0 4 1 0 4 4 4 2 Malarial early transcribed membrane protein (ETRAMP) OST-HTH PF12872.7 ETO29302.1 - 1.4e-07 31.3 0.4 0.00018 21.3 0.1 3.4 3 0 0 3 3 3 2 OST-HTH/LOTUS domain Cys_rich_KTR PF14205.6 ETO29302.1 - 0.011 15.5 0.9 0.035 13.9 0.9 1.9 1 0 0 1 1 1 0 Cysteine-rich KTR RRM_1 PF00076.22 ETO29302.1 - 0.03 14.2 0.0 0.1 12.4 0.0 2.0 2 0 0 2 2 2 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FAD_SOX PF18371.1 ETO29302.1 - 0.096 13.1 0.9 0.45 10.9 0.1 2.6 3 0 0 3 3 3 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase CheX PF13690.6 ETO29302.1 - 0.16 12.2 0.5 0.68 10.1 0.0 2.3 2 0 0 2 2 2 0 Chemotaxis phosphatase CheX DUF4364 PF14277.6 ETO29304.1 - 0.024 14.4 2.5 0.077 12.7 2.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4364) PRKCSH PF07915.13 ETO29304.1 - 0.18 12.8 2.0 1.6 9.8 0.0 3.4 3 1 0 3 3 3 0 Glucosidase II beta subunit-like protein cNMP_binding PF00027.29 ETO29305.1 - 4.7e-11 42.6 0.2 7e-06 26.0 0.0 3.1 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain SR-25 PF10500.9 ETO29305.1 - 0.0026 17.4 6.1 0.0026 17.4 6.1 5.8 5 1 2 7 7 7 1 Nuclear RNA-splicing-associated protein APG6_N PF17675.1 ETO29306.1 - 0.0016 19.0 30.5 0.0016 19.0 30.5 2.6 2 1 0 2 2 2 1 Apg6 coiled-coil region CCDC144C PF14915.6 ETO29306.1 - 0.0025 17.0 47.6 0.0026 16.9 27.9 2.2 2 0 0 2 2 2 2 CCDC144C protein coiled-coil region SKA2 PF16740.5 ETO29306.1 - 0.011 15.5 6.7 0.011 15.5 6.7 3.8 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 HMMR_C PF15908.5 ETO29306.1 - 0.025 14.8 9.9 0.025 14.8 9.9 3.9 2 2 2 4 4 4 0 Hyaluronan mediated motility receptor C-terminal DivIC PF04977.15 ETO29306.1 - 0.027 14.2 1.7 0.027 14.2 1.7 5.8 2 2 4 6 6 6 0 Septum formation initiator Rab5-bind PF09311.11 ETO29306.1 - 0.028 13.8 41.3 0.33 10.3 41.3 2.1 1 1 0 1 1 1 0 Rabaptin-like protein Exonuc_VII_L PF02601.15 ETO29306.1 - 0.07 12.7 35.9 0.047 13.3 20.2 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit Fez1 PF06818.15 ETO29306.1 - 0.099 13.1 45.9 0.04 14.4 23.9 2.6 1 1 1 3 3 3 0 Fez1 ApoO PF09769.9 ETO29306.1 - 0.2 11.6 0.2 0.2 11.6 0.2 3.6 2 1 0 2 2 1 0 Apolipoprotein O Spc7 PF08317.11 ETO29306.1 - 0.2 10.5 47.1 0.061 12.2 4.4 3.0 2 1 1 3 3 3 0 Spc7 kinetochore protein HOOK PF05622.12 ETO29306.1 - 0.43 8.7 42.5 0.13 10.3 23.1 2.0 2 0 0 2 2 2 0 HOOK protein SHE3 PF17078.5 ETO29306.1 - 0.49 10.1 44.5 0.47 10.1 17.2 3.1 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 DUF3584 PF12128.8 ETO29306.1 - 0.85 7.0 44.9 0.0075 13.9 24.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) WXG100 PF06013.12 ETO29306.1 - 1 9.6 24.5 1.1 9.5 2.7 4.1 2 1 0 3 3 3 0 Proteins of 100 residues with WXG T2SSF PF00482.23 ETO29306.1 - 2 8.4 4.4 11 6.0 0.4 3.0 2 2 1 3 3 3 0 Type II secretion system (T2SS), protein F Alpha-2-MRAP_C PF06401.11 ETO29306.1 - 2.2 8.2 47.8 0.42 10.5 18.8 2.4 1 1 1 2 2 2 0 Alpha-2-macroglobulin RAP, C-terminal domain Golgin_A5 PF09787.9 ETO29306.1 - 2.6 7.4 47.9 4.2 6.8 27.0 3.0 2 1 1 3 3 3 0 Golgin subfamily A member 5 ERM PF00769.19 ETO29306.1 - 2.8 7.7 44.8 4.3 7.1 24.8 2.4 2 0 0 2 2 2 0 Ezrin/radixin/moesin family Peptidase_S46 PF10459.9 ETO29306.1 - 7.9 5.0 36.3 0.46 9.1 9.3 2.0 2 0 0 2 2 2 0 Peptidase S46 TerB PF05099.13 ETO29306.1 - 8.9 6.3 11.4 1.4 8.9 3.9 2.8 2 1 0 2 2 2 0 Tellurite resistance protein TerB DUF1664 PF07889.12 ETO29306.1 - 9.2 6.3 31.2 0.42 10.6 7.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) Choline_transpo PF04515.12 ETO29307.1 - 1.2e-15 57.6 4.3 1.2e-15 57.6 4.3 2.2 2 0 0 2 2 2 1 Plasma-membrane choline transporter Phage_holin_3_6 PF07332.11 ETO29307.1 - 4.9 7.2 7.0 11 6.1 0.1 2.4 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III Choline_transpo PF04515.12 ETO29308.1 - 4.2e-54 183.9 21.0 5.1e-54 183.7 21.0 1.1 1 0 0 1 1 1 1 Plasma-membrane choline transporter GTA_holin_3TM PF11351.8 ETO29308.1 - 0.055 14.0 0.4 0.14 12.7 0.4 1.7 1 0 0 1 1 1 0 Holin of 3TMs, for gene-transfer release DUF3439 PF11921.8 ETO29310.1 - 0.15 12.0 7.6 0.4 10.6 7.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Androgen_recep PF02166.16 ETO29310.1 - 0.29 9.9 7.2 0.34 9.7 7.2 1.1 1 0 0 1 1 1 0 Androgen receptor ATAD4 PF15321.6 ETO29310.1 - 0.31 12.4 3.7 0.37 12.2 1.8 2.0 2 0 0 2 2 2 0 ATPase family AAA domain containing 4 GCP_N_terminal PF17681.1 ETO29311.1 - 3.4e-15 56.5 0.2 4.6e-10 39.6 0.0 2.0 2 0 0 2 2 2 2 Gamma tubulin complex component N-terminal DrsE_2 PF13686.6 ETO29311.1 - 0.055 13.4 0.7 0.086 12.7 0.7 1.2 1 0 0 1 1 1 0 DsrE/DsrF/DrsH-like family Wbp11 PF09429.10 ETO29314.1 - 1.3e-14 54.4 11.2 1.3e-14 54.4 11.2 2.9 2 1 1 3 3 3 1 WW domain binding protein 11 Sec1 PF00995.23 ETO29315.1 - 2e-83 281.6 4.0 2.3e-83 281.4 4.0 1.0 1 0 0 1 1 1 1 Sec1 family DUF4763 PF15960.5 ETO29315.1 - 0.62 9.3 3.8 0.35 10.1 1.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) HIT PF01230.23 ETO29316.1 - 2.1e-23 82.9 0.1 3.7e-23 82.1 0.1 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ETO29316.1 - 2.9e-09 37.4 0.0 5e-09 36.6 0.0 1.3 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding CwfJ_C_1 PF04677.15 ETO29316.1 - 0.086 12.7 0.2 0.16 11.8 0.2 1.5 1 1 0 1 1 1 0 Protein similar to CwfJ C-terminus 1 LepA_C PF06421.12 ETO29317.1 - 1.8e-38 131.0 3.6 3.1e-38 130.2 3.6 1.4 1 0 0 1 1 1 1 GTP-binding protein LepA C-terminus EFG_C PF00679.24 ETO29317.1 - 1.5e-12 47.4 0.0 4.1e-12 46.0 0.0 1.8 1 0 0 1 1 1 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETO29317.1 - 2e-06 28.1 0.0 5.4e-06 26.7 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu domain 2 EFG_II PF14492.6 ETO29317.1 - 0.0013 18.8 0.0 0.0026 17.8 0.0 1.5 1 0 0 1 1 1 1 Elongation Factor G, domain II RF3_C PF16658.5 ETO29317.1 - 0.0074 16.1 0.0 0.013 15.4 0.0 1.4 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain adh_short PF00106.25 ETO29318.1 - 4.8e-30 104.5 0.0 6.8e-30 104.0 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO29318.1 - 1.8e-19 70.3 0.0 2.4e-19 69.8 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO29318.1 - 5e-08 33.1 0.0 7.7e-08 32.4 0.0 1.2 1 0 0 1 1 1 1 KR domain SNARE_assoc PF09335.11 ETO29319.1 - 1e-07 32.4 0.4 2.3e-07 31.3 0.4 1.5 1 0 0 1 1 1 1 SNARE associated Golgi protein BDV_P10 PF06515.11 ETO29319.1 - 0.069 13.2 0.7 0.069 13.2 0.7 1.6 2 0 0 2 2 2 0 Borna disease virus P10 protein DUF2431 PF10354.9 ETO29320.1 - 8e-40 136.9 1.3 1.1e-39 136.4 0.5 1.6 2 0 0 2 2 2 1 Domain of unknown function (DUF2431) FDX-ACB PF03147.14 ETO29320.1 - 0.00022 21.6 0.1 0.0014 19.0 0.0 2.5 2 1 0 2 2 2 1 Ferredoxin-fold anticodon binding domain F-box-like PF12937.7 ETO29320.1 - 0.0012 18.6 0.1 0.0039 17.0 0.1 1.8 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO29320.1 - 0.17 11.8 3.5 0.43 10.5 0.7 2.7 2 1 0 2 2 2 0 F-box domain Ofd1_CTDD PF10637.9 ETO29323.1 - 2.3e-07 30.4 0.5 2.3e-07 30.4 0.5 1.8 2 1 1 3 3 3 1 Oxoglutarate and iron-dependent oxygenase degradation C-term CENP-B_dimeris PF09026.10 ETO29323.1 - 0.28 11.6 10.3 0.068 13.6 6.4 1.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain RRM_1 PF00076.22 ETO29326.1 - 6.7e-06 25.8 0.0 1.4e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RrnaAD PF00398.20 ETO29326.1 - 0.00046 19.3 0.0 0.00078 18.6 0.0 1.3 1 0 0 1 1 1 1 Ribosomal RNA adenine dimethylase Limkain-b1 PF11608.8 ETO29326.1 - 0.0063 16.6 0.1 0.032 14.3 0.0 2.2 2 0 0 2 2 2 1 Limkain b1 Methyltransf_15 PF09445.10 ETO29326.1 - 0.011 15.3 0.0 0.031 13.9 0.0 1.8 1 0 0 1 1 1 0 RNA cap guanine-N2 methyltransferase RRM_5 PF13893.6 ETO29326.1 - 0.013 15.1 0.0 0.031 13.8 0.0 1.6 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO29326.1 - 0.016 15.1 0.0 0.043 13.7 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif DHDPS PF00701.22 ETO29327.1 - 0.016 13.9 0.0 0.037 12.8 0.0 1.5 2 0 0 2 2 2 0 Dihydrodipicolinate synthetase family Ala_racemase_N PF01168.20 ETO29329.1 - 5.1e-09 36.1 0.0 1e-08 35.1 0.0 1.5 1 0 0 1 1 1 1 Alanine racemase, N-terminal domain D-ser_dehydrat PF14031.6 ETO29329.1 - 2.8e-08 34.3 0.0 7.1e-08 33.0 0.0 1.7 1 0 0 1 1 1 1 Putative serine dehydratase domain KOW PF00467.29 ETO29330.1 - 1.4e-05 24.9 5.3 4.9e-05 23.1 0.3 2.8 2 0 0 2 2 2 1 KOW motif FixO PF02433.15 ETO29330.1 - 0.57 9.6 7.0 0.059 12.8 2.4 1.7 2 0 0 2 2 2 0 Cytochrome C oxidase, mono-heme subunit/FixO zf-C2H2 PF00096.26 ETO29332.1 - 1.3e-06 28.6 21.9 0.00058 20.2 0.9 4.1 3 0 0 3 3 3 2 Zinc finger, C2H2 type AT_hook PF02178.19 ETO29332.1 - 0.0082 15.9 31.0 0.21 11.5 1.1 4.1 3 0 0 3 3 3 3 AT hook motif zf-H2C2_2 PF13465.6 ETO29332.1 - 0.026 14.9 18.4 0.17 12.3 2.9 4.7 4 0 0 4 4 4 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO29332.1 - 0.087 13.7 27.8 0.6 11.1 0.8 4.7 4 1 0 4 4 4 0 C2H2-type zinc finger Spore_Cse60 PF10957.8 ETO29333.1 - 0.22 11.6 3.7 1.9 8.6 0.7 2.8 2 1 0 2 2 2 0 Sporulation protein Cse60 CDC45 PF02724.14 ETO29334.1 - 0.31 9.3 10.3 0.37 9.0 10.3 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4407 PF14362.6 ETO29334.1 - 2 7.7 8.4 2.5 7.4 8.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) G-alpha PF00503.20 ETO29335.1 - 2.4e-58 198.0 4.7 2.1e-57 194.9 4.7 1.9 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO29335.1 - 1.6e-07 30.9 0.2 0.0099 15.3 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family ATPase_2 PF01637.18 ETO29335.1 - 0.0056 16.6 0.7 0.01 15.8 0.4 1.6 1 1 0 1 1 1 1 ATPase domain predominantly from Archaea Gtr1_RagA PF04670.12 ETO29335.1 - 0.012 15.0 0.5 4.9 6.4 0.1 2.6 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region Roc PF08477.13 ETO29335.1 - 0.013 15.8 0.1 0.14 12.4 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase GAD PF02938.14 ETO29335.1 - 0.035 14.3 0.0 0.084 13.1 0.0 1.7 1 0 0 1 1 1 0 GAD domain AAA_14 PF13173.6 ETO29335.1 - 0.046 13.8 0.2 0.35 10.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain AAA_15 PF13175.6 ETO29335.1 - 0.057 13.1 1.2 0.062 13.0 0.1 1.6 2 0 0 2 2 2 0 AAA ATPase domain Mg_chelatase PF01078.21 ETO29335.1 - 0.091 12.1 0.0 0.15 11.4 0.0 1.2 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI NB-ARC PF00931.22 ETO29335.1 - 0.1 11.8 0.0 0.16 11.1 0.0 1.4 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 ETO29335.1 - 0.15 12.2 0.0 2.1 8.5 0.0 2.3 1 1 0 1 1 1 0 50S ribosome-binding GTPase HTH_48 PF17906.1 ETO29335.1 - 0.23 11.6 1.5 2.4 8.3 0.3 2.6 2 0 0 2 2 2 0 HTH domain in Mos1 transposase CTP_transf_like PF01467.26 ETO29336.1 - 2.9e-07 30.8 0.0 3.8e-07 30.4 0.0 1.1 1 0 0 1 1 1 1 Cytidylyltransferase-like Beach PF02138.18 ETO29338.1 - 1.3e-120 402.0 0.1 2.4e-120 401.1 0.1 1.5 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.21 ETO29338.1 - 4.8e-16 58.7 14.9 1e-15 57.6 14.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger WD40 PF00400.32 ETO29338.1 - 1.3e-13 51.2 17.0 1.1e-06 29.3 0.1 5.5 4 1 0 5 5 5 4 WD domain, G-beta repeat PH_BEACH PF14844.6 ETO29338.1 - 4e-12 46.1 0.5 4e-12 46.1 0.5 2.5 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH ANAPC4_WD40 PF12894.7 ETO29338.1 - 0.0005 20.3 0.7 0.016 15.5 0.1 3.4 3 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IBR PF01485.21 ETO29338.1 - 0.5 10.6 9.0 1.7 9.0 9.0 1.9 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain AAA_lid_8 PF17868.1 ETO29339.1 - 0.077 12.9 0.5 0.16 11.9 0.5 1.5 1 0 0 1 1 1 0 AAA lid domain PdaC PF13739.6 ETO29339.1 - 0.35 11.9 2.5 0.5 11.4 2.5 1.2 1 0 0 1 1 1 0 Deacetylase PdaC Ribosomal_L13e PF01294.18 ETO29341.1 - 2.3e-22 79.7 2.5 1.8e-21 76.8 0.6 3.0 2 1 1 3 3 3 2 Ribosomal protein L13e KapB PF08810.10 ETO29341.1 - 0.16 12.2 0.4 0.16 12.2 0.4 2.4 2 1 1 3 3 3 0 Kinase associated protein B STOP PF05217.12 ETO29342.1 - 0.055 13.8 0.1 0.17 12.2 0.1 1.9 1 0 0 1 1 1 0 STOP protein HD-ZIP_N PF04618.12 ETO29343.1 - 0.62 10.6 3.9 0.29 11.6 0.2 2.2 2 1 1 3 3 3 0 HD-ZIP protein N terminus HD-ZIP_N PF04618.12 ETO29344.1 - 0.62 10.6 3.9 0.29 11.6 0.2 2.2 2 1 1 3 3 3 0 HD-ZIP protein N terminus Pkinase PF00069.25 ETO29345.1 - 5.8e-38 130.8 0.0 7.7e-38 130.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29345.1 - 1.2e-19 70.7 0.0 1.5e-19 70.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO29345.1 - 0.00079 18.8 0.0 0.17 11.2 0.0 2.1 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ETO29345.1 - 0.038 13.9 0.1 0.063 13.2 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Choline_kinase PF01633.20 ETO29345.1 - 0.05 13.2 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ETO29345.1 - 0.096 11.6 0.0 0.18 10.7 0.0 1.4 1 1 0 1 1 1 0 Haspin like kinase domain Kdo PF06293.14 ETO29345.1 - 0.17 11.2 0.0 0.28 10.5 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Pribosyltran PF00156.27 ETO29346.1 - 2.9e-19 69.1 0.0 4.4e-19 68.5 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ETO29346.1 - 0.0042 16.6 0.0 0.0064 16.0 0.0 1.3 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ETO29346.1 - 0.03 13.8 0.0 0.046 13.2 0.0 1.2 1 0 0 1 1 1 0 Phosphoribosyl transferase tRNA_synthFbeta PF17759.1 ETO29347.1 - 7.7e-35 120.3 0.0 4.6e-19 68.7 0.0 2.3 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain B3_4 PF03483.17 ETO29347.1 - 1.2e-25 90.2 0.0 3.5e-25 88.7 0.0 1.8 2 0 0 2 2 2 1 B3/4 domain PhetRS_B1 PF18262.1 ETO29347.1 - 4.9e-17 61.9 0.7 3e-08 33.8 0.2 3.1 3 0 0 3 3 3 2 Phe-tRNA synthetase beta subunit B1 domain B5 PF03484.15 ETO29347.1 - 3.8e-15 55.9 0.0 1e-14 54.5 0.0 1.8 1 0 0 1 1 1 1 tRNA synthetase B5 domain DUF1336 PF07059.12 ETO29348.1 - 5.6e-58 196.7 0.0 8.6e-58 196.1 0.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) PI3K_rbd PF00794.18 ETO29349.1 - 0.022 14.9 0.2 0.094 12.9 0.2 2.1 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain GTP_EFTU_D3 PF03143.17 ETO29350.1 - 0.00013 22.2 0.1 0.00042 20.6 0.0 1.8 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETO29350.1 - 0.18 12.2 0.0 0.34 11.3 0.0 1.4 1 0 0 1 1 1 0 Elongation factor Tu domain 2 DUF3290 PF11694.8 ETO29350.1 - 1.6 8.7 6.1 4.1 7.4 1.9 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) DUF2070 PF09843.9 ETO29350.1 - 4.6 5.4 8.2 6.8 4.9 8.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) SAM_2 PF07647.17 ETO29351.1 - 3.6e-05 23.8 0.0 5.8e-05 23.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO29351.1 - 7e-05 23.2 0.0 0.0001 22.6 0.0 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) BSP_II PF05432.11 ETO29351.1 - 0.0011 18.7 12.0 0.0014 18.4 12.0 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) PX PF00787.24 ETO29351.1 - 0.0016 18.4 0.1 0.0026 17.7 0.1 1.4 1 0 0 1 1 1 1 PX domain SAM_Ste50p PF09235.10 ETO29351.1 - 0.003 17.8 0.1 0.0092 16.2 0.1 1.8 1 1 1 2 2 2 1 Ste50p, sterile alpha motif Nop14 PF04147.12 ETO29351.1 - 0.0036 15.6 4.7 0.0043 15.4 4.7 1.2 1 0 0 1 1 1 1 Nop14-like family CNDH2_C PF16858.5 ETO29351.1 - 0.023 14.6 0.3 0.031 14.1 0.3 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RNA_pol_3_Rpc31 PF11705.8 ETO29351.1 - 0.072 13.3 10.0 0.11 12.8 10.0 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 TRAP_alpha PF03896.16 ETO29351.1 - 0.089 12.0 1.0 0.12 11.5 1.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit CDC45 PF02724.14 ETO29351.1 - 0.1 10.9 2.4 0.11 10.8 2.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF2457 PF10446.9 ETO29351.1 - 0.79 8.8 11.3 1.1 8.4 11.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO29351.1 - 1.8 6.6 16.2 1.6 6.8 13.9 1.8 2 0 0 2 2 2 0 DNA polymerase phi GEN1_C PF18380.1 ETO29351.1 - 2.5 9.1 6.8 11 7.0 2.9 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain SDA1 PF05285.12 ETO29351.1 - 2.6 7.4 13.3 0.073 12.5 5.3 1.9 2 0 0 2 2 2 0 SDA1 NOA36 PF06524.12 ETO29351.1 - 2.8 7.2 11.0 4.1 6.6 11.0 1.3 1 0 0 1 1 1 0 NOA36 protein CobT PF06213.12 ETO29351.1 - 2.8 7.2 12.8 3.8 6.8 12.8 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT GRP PF07172.11 ETO29351.1 - 5.3 7.8 12.8 9.9 6.9 12.8 1.4 1 0 0 1 1 1 0 Glycine rich protein family Pkinase PF00069.25 ETO29352.1 - 5.4e-14 52.2 0.2 1.1e-09 38.1 0.0 3.5 2 2 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29352.1 - 7.2e-11 41.9 1.7 2.7e-10 40.0 0.2 2.5 2 1 0 2 2 2 1 Protein tyrosine kinase DUF4637 PF15470.6 ETO29352.1 - 8.4 6.1 31.8 2.3 7.9 5.2 3.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4637) Pkinase_Tyr PF07714.17 ETO29353.1 - 3.8e-14 52.6 0.1 4e-12 46.0 0.1 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO29353.1 - 2e-06 27.4 0.0 2.6e-06 27.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Rieske PF00355.26 ETO29354.1 - 3.2e-08 33.4 0.1 6.3e-08 32.5 0.1 1.5 1 0 0 1 1 1 1 Rieske [2Fe-2S] domain Rieske_2 PF13806.6 ETO29354.1 - 3.4e-07 30.1 0.0 5.6e-07 29.5 0.0 1.5 1 1 0 1 1 1 1 Rieske-like [2Fe-2S] domain DMAP1 PF05499.12 ETO29354.1 - 0.063 13.2 1.5 0.12 12.3 1.5 1.4 1 0 0 1 1 1 0 DNA methyltransferase 1-associated protein 1 (DMAP1) PAPA-1 PF04795.12 ETO29354.1 - 0.7 10.7 4.6 0.17 12.7 1.4 1.6 2 0 0 2 2 2 0 PAPA-1-like conserved region LRR_4 PF12799.7 ETO29355.1 - 0.0019 18.6 1.3 0.0081 16.6 0.5 2.3 2 0 0 2 2 2 1 Leucine Rich repeats (2 copies) HR1 PF02185.16 ETO29356.1 - 0.29 11.3 7.8 0.18 11.9 0.2 3.1 2 1 0 2 2 2 0 Hr1 repeat FKBP_C PF00254.28 ETO29358.1 - 1.5e-26 92.5 0.0 2.4e-26 91.9 0.0 1.2 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase MORN PF02493.20 ETO29358.1 - 0.084 12.8 1.0 0.22 11.5 1.0 1.8 1 0 0 1 1 1 0 MORN repeat zf-CCCH_4 PF18044.1 ETO29359.1 - 7.3e-06 25.7 0.8 1.8e-05 24.4 0.8 1.7 1 0 0 1 1 1 1 CCCH-type zinc finger zf_CCCH_4 PF18345.1 ETO29359.1 - 6.2e-05 22.9 3.1 0.00014 21.7 3.1 1.6 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH PF00642.24 ETO29359.1 - 0.0035 17.2 0.5 0.0073 16.2 0.5 1.5 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Torus PF16131.5 ETO29359.1 - 0.0097 16.6 1.5 0.021 15.5 0.4 2.1 1 1 0 1 1 1 1 Torus domain SNase PF00565.17 ETO29361.1 - 1.1e-27 96.6 36.0 2.9e-10 40.6 2.1 8.0 5 4 1 6 6 6 5 Staphylococcal nuclease homologue TUDOR PF00567.24 ETO29361.1 - 3.8e-11 43.1 0.0 1.3e-10 41.3 0.0 2.0 2 0 0 2 2 2 1 Tudor domain Myc_N PF01056.18 ETO29362.1 - 0.13 12.2 8.9 0.19 11.6 8.4 1.6 1 1 0 1 1 1 0 Myc amino-terminal region MCD PF05292.11 ETO29363.1 - 3.4 7.2 11.4 0.086 12.4 2.0 2.4 1 1 1 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain WD40 PF00400.32 ETO29364.1 - 1.7e-44 148.9 8.8 4.4e-10 40.0 0.0 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29364.1 - 1.9e-15 56.9 0.1 0.0029 17.9 0.0 4.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO29364.1 - 3.2e-11 43.5 0.1 0.0032 17.4 0.0 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO29364.1 - 1.1e-09 37.8 0.2 0.55 9.1 0.0 5.2 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29364.1 - 5e-07 29.3 0.1 0.0051 16.2 0.0 2.3 2 0 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO29364.1 - 8.7e-06 25.5 0.1 15 5.7 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO29364.1 - 0.00036 19.7 0.5 0.0032 16.6 0.1 2.0 1 1 0 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO29364.1 - 0.00073 18.2 0.0 0.037 12.6 0.0 2.1 2 0 0 2 2 2 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO29364.1 - 0.0029 16.3 2.4 5.8 5.4 0.0 3.8 2 2 2 4 4 4 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO29364.1 - 0.011 15.7 0.0 2.1 8.4 0.0 2.6 2 0 0 2 2 2 0 PQQ enzyme repeat DUF4131 PF13567.6 ETO29364.1 - 0.28 10.8 3.7 0.5 10.0 3.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4131) WD40 PF00400.32 ETO29365.1 - 5.7e-44 147.2 27.1 8e-08 32.8 0.7 7.8 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29365.1 - 1.7e-10 41.1 0.4 0.013 15.7 0.0 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29365.1 - 6.9e-08 31.6 5.9 0.011 14.4 0.3 5.0 2 2 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29365.1 - 0.00035 20.0 4.2 4.3 6.6 0.2 4.2 3 1 1 4 4 4 3 WD40-like domain HARP PF07443.13 ETO29365.1 - 0.024 14.3 0.0 14 5.4 0.0 3.4 3 0 0 3 3 3 0 HepA-related protein (HARP) CoA_transf_3 PF02515.17 ETO29366.1 - 0.11 11.6 4.0 0.13 11.3 0.2 2.2 2 0 0 2 2 2 0 CoA-transferase family III PAP_assoc PF03828.19 ETO29369.1 - 2.9e-09 37.0 0.2 1.1e-08 35.1 0.0 2.2 2 0 0 2 2 2 1 Cid1 family poly A polymerase NTP_transf_2 PF01909.23 ETO29369.1 - 7.9e-05 22.9 0.0 0.00021 21.5 0.0 1.8 1 1 0 1 1 1 1 Nucleotidyltransferase domain Polbeta PF18765.1 ETO29369.1 - 0.02 14.9 0.0 0.055 13.6 0.0 1.7 1 0 0 1 1 1 0 Polymerase beta, Nucleotidyltransferase tRNA_NucTransf2 PF09249.11 ETO29369.1 - 0.1 12.9 0.0 0.31 11.3 0.0 1.8 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain DUF4269 PF14091.6 ETO29369.1 - 0.12 12.6 0.0 0.28 11.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4269) SelP_N PF04592.14 ETO29369.1 - 3.1 7.1 13.7 0.055 12.9 6.1 1.9 2 0 0 2 2 2 0 Selenoprotein P, N terminal region IP_trans PF02121.18 ETO29370.1 - 0.23 11.0 3.5 2.8 7.5 0.2 2.0 1 1 1 2 2 2 0 Phosphatidylinositol transfer protein AgrB PF04647.15 ETO29371.1 - 0.0011 18.4 1.4 0.0011 18.4 1.4 2.4 1 1 2 3 3 3 1 Accessory gene regulator B ETRAMP PF09716.10 ETO29371.1 - 0.023 14.7 1.7 5.7 7.1 0.0 3.6 2 2 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) GET2 PF08690.10 ETO29371.1 - 0.11 12.1 0.6 0.23 11.1 0.6 1.5 1 0 0 1 1 1 0 GET complex subunit GET2 DUF4010 PF13194.6 ETO29371.1 - 0.12 12.0 4.7 0.12 12.0 0.5 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4010) Tmemb_18A PF09771.9 ETO29371.1 - 1.3 9.5 7.2 0.069 13.5 1.1 2.0 2 1 0 2 2 2 0 Transmembrane protein 188 DUF515 PF04415.12 ETO29372.1 - 0.017 13.6 9.1 0.031 12.7 9.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF515) SAM_2 PF07647.17 ETO29372.1 - 0.018 15.1 0.1 0.044 13.9 0.1 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO29372.1 - 0.027 14.9 0.0 0.058 13.9 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Mucin PF01456.17 ETO29372.1 - 0.19 11.7 23.6 7.9 6.5 0.1 2.5 2 0 0 2 2 2 0 Mucin-like glycoprotein SSP160 PF06933.11 ETO29372.1 - 1.4 7.0 16.0 2.4 6.2 16.0 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 DAGK_cat PF00781.24 ETO29374.1 - 4.1e-07 29.7 1.5 5.7e-07 29.2 0.0 2.0 2 1 1 3 3 3 1 Diacylglycerol kinase catalytic domain FHIPEP PF00771.20 ETO29374.1 - 1.6 7.1 8.2 2.3 6.6 8.2 1.2 1 0 0 1 1 1 0 FHIPEP family Membralin PF09746.9 ETO29374.1 - 3.9 6.4 7.8 7.4 5.5 7.8 1.5 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO29374.1 - 6.7 5.4 18.4 0.23 10.2 11.8 1.7 2 0 0 2 2 2 0 Presenilin Sec62 PF03839.16 ETO29374.1 - 8.9 5.8 20.2 28 4.1 0.2 2.6 2 0 0 2 2 2 0 Translocation protein Sec62 CDC45 PF02724.14 ETO29377.1 - 0.013 13.8 6.7 0.005 15.2 3.6 1.7 2 0 0 2 2 2 0 CDC45-like protein DAGAT PF03982.13 ETO29377.1 - 0.13 11.2 0.1 0.19 10.6 0.1 1.2 1 0 0 1 1 1 0 Diacylglycerol acyltransferase DNA_pol_phi PF04931.13 ETO29377.1 - 0.74 7.8 19.5 1.4 6.9 19.5 1.3 1 0 0 1 1 1 0 DNA polymerase phi YL1 PF05764.13 ETO29377.1 - 2.1 8.4 13.9 0.027 14.6 3.8 2.2 2 0 0 2 2 2 0 YL1 nuclear protein DUF2457 PF10446.9 ETO29377.1 - 2.6 7.1 23.1 0.034 13.3 13.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.12 ETO29377.1 - 6.6 6.4 23.6 0.29 10.8 16.1 2.4 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein DUF4205 PF13898.6 ETO29380.1 - 6.3e-20 71.4 0.0 1.4e-16 60.3 0.0 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4205) zf-RanBP PF00641.18 ETO29380.1 - 1.4e-05 24.3 2.4 2.4e-05 23.6 2.4 1.4 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO29380.1 - 0.017 14.5 3.6 0.049 13.0 3.6 1.8 1 1 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain PTSIIA_gutA PF03829.13 ETO29380.1 - 0.12 12.3 0.1 0.99 9.3 0.0 2.3 2 0 0 2 2 2 0 PTS system glucitol/sorbitol-specific IIA component zf-Sec23_Sec24 PF04810.15 ETO29380.1 - 0.62 10.2 6.2 0.24 11.5 3.2 2.0 1 1 0 1 1 1 0 Sec23/Sec24 zinc finger FAM177 PF14774.6 ETO29382.1 - 1.7e-12 47.7 6.4 1.7e-12 47.7 6.4 2.5 2 1 0 2 2 2 1 FAM177 family G0-G1_switch_2 PF15103.6 ETO29382.1 - 0.031 14.7 0.1 0.031 14.7 0.1 3.0 1 1 2 3 3 3 0 G0/G1 switch protein 2 DUF1501 PF07394.12 ETO29382.1 - 0.033 13.3 3.4 0.015 14.4 1.1 1.5 1 1 1 2 2 2 0 Protein of unknown function (DUF1501) ArAE_2_N PF10337.9 ETO29382.1 - 1.1 8.2 4.4 1.5 7.7 4.4 1.2 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal RSRP PF17069.5 ETO29382.1 - 3.8 7.0 6.3 0.25 10.9 0.7 1.6 2 0 0 2 2 2 0 Arginine/Serine-Rich protein 1 TMEM51 PF15345.6 ETO29385.1 - 8 6.2 10.6 2.4 8.0 6.5 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 MatE PF01554.18 ETO29386.1 - 2.4e-44 150.9 37.1 2e-24 86.1 6.6 2.6 3 0 0 3 3 3 2 MatE PGA2 PF07543.12 ETO29386.1 - 0.0026 17.7 0.7 0.0047 16.9 0.7 1.3 1 0 0 1 1 1 1 Protein trafficking PGA2 TLP-20 PF06088.11 ETO29386.1 - 0.0099 15.8 6.6 0.019 14.9 6.6 1.4 1 0 0 1 1 1 1 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Inhibitor_I71 PF12628.7 ETO29386.1 - 0.048 13.5 4.6 0.095 12.5 4.6 1.5 1 0 0 1 1 1 0 Falstatin, cysteine peptidase inhibitor RPA43_OB PF17875.1 ETO29386.1 - 0.12 13.1 0.4 0.22 12.1 0.4 1.4 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Sporozoite_P67 PF05642.11 ETO29386.1 - 0.44 8.6 2.4 0.65 8.0 2.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CENP-B_dimeris PF09026.10 ETO29386.1 - 1.1 9.7 11.4 2.4 8.6 11.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF5520 PF17658.1 ETO29386.1 - 2.1 7.4 6.1 3.4 6.7 6.1 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5520) Tom22 PF04281.13 ETO29386.1 - 8.8 6.1 11.5 1.4 8.7 0.1 2.4 2 0 0 2 2 2 0 Mitochondrial import receptor subunit Tom22 Sulfotransfer_4 PF17784.1 ETO29387.1 - 1.2e-10 41.6 2.3 7e-10 39.1 2.3 2.1 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO29387.1 - 5.4e-05 23.7 0.2 0.00015 22.2 0.2 1.8 1 1 0 1 1 1 1 Sulfotransferase family 3Beta_HSD PF01073.19 ETO29388.1 - 4.6e-12 45.5 0.2 6.4e-12 45.1 0.2 1.2 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO29388.1 - 1.6e-05 24.5 0.0 2.3e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETO29388.1 - 0.0047 16.1 0.0 0.0068 15.6 0.0 1.2 1 0 0 1 1 1 1 Male sterility protein RmlD_sub_bind PF04321.17 ETO29388.1 - 0.017 14.2 0.0 0.022 13.9 0.0 1.2 1 0 0 1 1 1 0 RmlD substrate binding domain COMM_domain PF07258.14 ETO29390.1 - 7.1e-10 38.9 6.4 1e-09 38.3 3.9 2.4 2 1 0 2 2 2 1 COMM domain zf-C3HC4_3 PF13920.6 ETO29391.1 - 1.6e-13 50.3 9.7 1.6e-13 50.3 9.7 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO29391.1 - 2.3e-09 36.9 10.1 5.1e-09 35.9 10.1 1.6 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO29391.1 - 0.0003 21.1 10.7 0.0003 21.1 10.7 1.9 2 0 0 2 2 2 1 Ring finger domain zf-RING_5 PF14634.6 ETO29391.1 - 0.0041 17.0 9.9 0.0041 17.0 9.9 1.7 2 0 0 2 2 2 1 zinc-RING finger domain DUF4193 PF13834.6 ETO29391.1 - 0.02 15.4 2.5 0.056 13.9 2.5 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4193) RecR PF02132.15 ETO29391.1 - 0.14 11.7 10.2 2.1 8.0 5.3 2.5 2 0 0 2 2 2 0 RecR protein zf-C3HC4 PF00097.25 ETO29391.1 - 0.44 10.5 11.6 1.1 9.2 11.6 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 ETO29391.1 - 0.73 9.9 9.4 58 3.7 9.4 2.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) zf-RING_UBOX PF13445.6 ETO29391.1 - 2.8 8.0 8.7 1.5 8.9 5.4 2.2 1 1 1 2 2 2 0 RING-type zinc-finger G-alpha PF00503.20 ETO29392.1 - 4.6e-18 65.5 11.0 9e-18 64.6 11.0 1.4 1 0 0 1 1 1 1 G-protein alpha subunit AA_permease_N PF08403.10 ETO29392.1 - 0.011 15.2 0.1 0.027 14.0 0.1 1.6 1 0 0 1 1 1 0 Amino acid permease N-terminal TrbM PF07424.11 ETO29392.1 - 0.034 14.1 0.2 0.081 12.9 0.0 1.6 2 0 0 2 2 2 0 TrbM Tubulin_C PF03953.17 ETO29393.1 - 1.6e-30 105.8 0.0 2.1e-30 105.4 0.0 1.1 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO29394.1 - 4e-59 200.2 0.3 1e-36 127.0 0.2 2.1 2 0 0 2 2 2 2 Tubulin/FtsZ family, GTPase domain Misat_Tub_SegII PF10644.9 ETO29394.1 - 0.019 15.3 0.0 0.032 14.5 0.0 1.4 1 0 0 1 1 1 0 Misato Segment II tubulin-like domain Condensin2nSMC PF12422.8 ETO29394.1 - 0.087 13.0 0.0 0.16 12.1 0.0 1.4 1 0 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit RPN6_N PF18055.1 ETO29395.1 - 5.3e-32 110.6 5.5 1e-31 109.7 3.1 2.3 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN6 N-terminal domain PCI PF01399.27 ETO29395.1 - 1.1e-13 51.6 0.5 1.1e-13 51.6 0.5 2.1 2 1 0 2 2 2 1 PCI domain RPN6_C_helix PF18503.1 ETO29395.1 - 0.006 16.3 0.5 0.006 16.3 0.5 2.0 2 0 0 2 2 2 1 26S proteasome subunit RPN6 C-terminal helix domain Sel1 PF08238.12 ETO29395.1 - 0.048 14.4 0.1 0.43 11.3 0.0 2.5 2 0 0 2 2 2 0 Sel1 repeat Beta-TrCP_D PF12125.8 ETO29396.1 - 0.16 11.9 1.5 0.16 11.9 0.0 1.8 2 0 0 2 2 2 0 D domain of beta-TrCP Pkinase PF00069.25 ETO29397.1 - 3.2e-55 187.3 0.1 3.7e-54 183.8 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29397.1 - 4.8e-20 71.9 0.0 1.4e-19 70.4 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO29397.1 - 0.0018 17.7 0.0 0.0023 17.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO29397.1 - 0.012 15.5 0.1 0.023 14.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ETO29397.1 - 0.018 14.4 0.0 0.027 13.8 0.0 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family YrbL-PhoP_reg PF10707.9 ETO29397.1 - 0.088 12.3 0.3 0.46 10.0 0.1 1.9 2 0 0 2 2 2 0 PhoP regulatory network protein YrbL EF-hand_1 PF00036.32 ETO29398.1 - 8.7e-32 106.3 6.9 9e-08 31.2 0.2 5.1 5 0 0 5 5 5 4 EF hand EF-hand_5 PF13202.6 ETO29398.1 - 1e-28 97.5 7.6 8.9e-07 28.1 0.0 5.1 5 0 0 5 5 5 4 EF hand EF-hand_7 PF13499.6 ETO29398.1 - 2.8e-25 88.5 2.6 3.3e-11 43.5 0.0 3.3 3 1 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO29398.1 - 2e-23 80.2 5.9 0.00011 21.9 0.0 5.1 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 ETO29398.1 - 3.9e-18 65.0 11.8 3.1e-08 33.3 0.4 5.0 3 1 2 5 5 5 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO29398.1 - 7.1e-09 36.0 2.9 0.0019 18.5 0.1 2.8 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO29398.1 - 3.1e-06 27.1 2.2 0.061 13.3 0.7 2.9 1 1 2 3 3 3 2 Cytoskeletal-regulatory complex EF hand Dockerin_1 PF00404.18 ETO29398.1 - 8.3e-05 22.7 2.7 0.096 12.9 0.6 2.9 2 2 0 2 2 2 2 Dockerin type I domain EF-hand_9 PF14658.6 ETO29398.1 - 0.012 15.9 0.3 11 6.5 0.0 2.8 2 1 0 2 2 2 0 EF-hand domain ArfGap PF01412.18 ETO29399.1 - 3.6e-36 123.8 5.4 3.1e-23 82.1 0.5 2.5 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf PH PF00169.29 ETO29400.1 - 4.8e-09 36.7 0.0 1.3e-08 35.3 0.0 1.8 1 0 0 1 1 1 1 PH domain FYVE PF01363.21 ETO29400.1 - 0.029 14.5 12.3 0.77 9.9 12.3 2.3 1 1 0 1 1 1 0 FYVE zinc finger PH_13 PF16652.5 ETO29400.1 - 0.035 13.9 6.4 0.63 9.8 0.1 2.7 1 1 1 3 3 3 0 Pleckstrin homology domain PH_16 PF17838.1 ETO29400.1 - 0.046 13.6 0.4 0.18 11.7 0.1 2.2 2 1 0 2 2 2 0 PH domain PH_17 PF18012.1 ETO29400.1 - 0.065 13.0 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 PH domain SAM35 PF10806.8 ETO29400.1 - 0.23 11.7 2.1 0.62 10.3 1.2 1.9 1 1 1 2 2 2 0 SAM35, subunit of SAM coomplex Sec7 PF01369.20 ETO29401.1 - 2.9e-34 118.3 0.0 5.2e-34 117.5 0.0 1.4 1 0 0 1 1 1 1 Sec7 domain DUF4423 PF14394.6 ETO29403.1 - 0.16 11.6 1.4 0.46 10.2 0.0 2.3 3 1 1 4 4 4 0 Domain of unknown function (DUF4423) Mnd1 PF03962.15 ETO29403.1 - 0.57 10.5 2.0 1.2 9.5 0.7 2.0 2 0 0 2 2 2 0 Mnd1 HTH domain LANC_like PF05147.13 ETO29405.1 - 1.6e-05 23.7 0.0 1.7e-05 23.5 0.0 1.1 1 0 0 1 1 1 1 Lanthionine synthetase C-like protein DUF3510 PF12022.8 ETO29406.1 - 2.9e-07 30.9 0.7 2.9e-07 30.9 0.7 2.4 3 0 0 3 3 3 1 Domain of unknown function (DUF3510) PUB PF09409.10 ETO29406.1 - 0.072 13.0 0.4 0.32 11.0 0.1 2.3 2 0 0 2 2 2 0 PUB domain CLTH PF10607.9 ETO29406.1 - 2.9 7.8 10.1 58 3.5 10.1 2.8 1 1 0 1 1 1 0 CTLH/CRA C-terminal to LisH motif domain WD40 PF00400.32 ETO29409.1 - 1.4e-68 225.2 20.8 4.7e-10 39.9 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29409.1 - 1.5e-20 73.2 1.3 1.9e-05 24.9 0.1 5.6 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29409.1 - 6e-13 48.5 0.2 0.00066 18.7 0.0 5.5 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29409.1 - 3.3e-06 26.6 0.0 0.061 12.6 0.0 3.3 1 1 3 4 4 4 3 WD40-like domain PD40 PF07676.12 ETO29409.1 - 7.1e-06 25.8 1.5 7.7 6.6 0.1 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO29409.1 - 0.00019 20.2 3.9 0.52 8.9 0.0 4.4 1 1 3 5 5 5 1 Nucleoporin Nup120/160 SoxZ PF08770.11 ETO29409.1 - 0.0028 17.4 0.0 37 4.2 0.0 4.1 5 0 0 5 5 5 0 Sulphur oxidation protein SoxZ Me-amine-dh_H PF06433.11 ETO29409.1 - 0.0034 16.3 0.0 0.55 9.0 0.0 2.9 2 1 2 4 4 4 1 Methylamine dehydrogenase heavy chain (MADH) Coatomer_WDAD PF04053.14 ETO29409.1 - 0.0078 15.3 0.2 0.31 10.1 0.0 2.6 1 1 2 3 3 3 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO29409.1 - 0.0095 14.5 0.4 1.1 7.8 0.0 3.1 2 1 2 4 4 4 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO29409.1 - 0.024 13.4 2.9 4.1 6.0 0.0 3.6 1 1 2 4 4 4 0 Nup133 N terminal like DUF5570 PF17731.1 ETO29409.1 - 0.072 13.2 2.8 20 5.3 0.0 4.1 2 1 4 6 6 6 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO29409.1 - 0.12 12.1 1.9 76 3.1 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Coatomer_E PF04733.14 ETO29411.1 - 6.4e-20 71.7 1.9 8.7e-20 71.3 1.9 1.2 1 0 0 1 1 1 1 Coatomer epsilon subunit Coatomer_E PF04733.14 ETO29412.1 - 1.3e-31 110.1 4.0 1.5e-31 109.9 4.0 1.0 1 0 0 1 1 1 1 Coatomer epsilon subunit TPR_19 PF14559.6 ETO29412.1 - 2.2e-06 28.1 2.0 0.0019 18.7 0.1 2.8 3 0 0 3 3 3 2 Tetratricopeptide repeat SesA PF17107.5 ETO29412.1 - 0.0037 17.4 1.2 0.093 12.9 0.2 2.2 1 1 0 2 2 2 1 N-terminal domain on NACHT_NTPase and P-loop NTPases TPR_14 PF13428.6 ETO29412.1 - 0.0038 17.9 0.3 16 6.6 0.0 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO29412.1 - 0.0095 16.1 0.9 0.035 14.3 0.5 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TSA PF03249.13 ETO29412.1 - 0.17 10.6 0.2 0.2 10.4 0.2 1.1 1 0 0 1 1 1 0 Type specific antigen UPF0542 PF15086.6 ETO29413.1 - 0.0067 16.3 0.5 0.0067 16.3 0.5 2.7 2 1 1 3 3 3 1 Uncharacterised protein family UPF0542 Astro_capsid_p PF12226.8 ETO29413.1 - 1.5 7.9 12.9 2.1 7.4 12.9 1.4 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 ETO29413.1 - 8.4 4.4 21.2 12 3.8 21.2 1.2 1 0 0 1 1 1 0 DNA polymerase phi GFA PF04828.14 ETO29414.1 - 3.7e-07 30.4 5.3 8.2e-07 29.3 5.3 1.6 1 0 0 1 1 1 1 Glutathione-dependent formaldehyde-activating enzyme PDR_CDR PF06422.12 ETO29414.1 - 0.15 11.9 7.0 4.6 7.2 0.0 2.9 3 1 0 3 3 3 0 CDR ABC transporter Peptidase_M16_C PF05193.21 ETO29415.1 - 2.3e-09 37.5 0.0 2.8e-09 37.2 0.0 1.1 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16_C PF05193.21 ETO29416.1 - 8.4e-13 48.7 0.0 1.8e-12 47.6 0.0 1.6 2 0 0 2 2 2 1 Peptidase M16 inactive domain NinB PF05772.12 ETO29416.1 - 5.4e-05 23.0 0.1 7.7e-05 22.5 0.1 1.2 1 0 0 1 1 1 1 NinB protein RhoGAP PF00620.27 ETO29417.1 - 4.6e-12 46.0 0.0 7.3e-12 45.4 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain PBD PF00786.28 ETO29417.1 - 0.0018 18.6 0.0 0.0057 17.0 0.0 2.0 1 0 0 1 1 1 1 P21-Rho-binding domain APP_E2 PF12925.7 ETO29418.1 - 0.00033 20.4 0.9 0.00051 19.8 0.9 1.2 1 0 0 1 1 1 1 E2 domain of amyloid precursor protein VGCC_beta4Aa_N PF12052.8 ETO29418.1 - 0.11 12.6 0.9 0.33 11.1 0.9 1.7 1 0 0 1 1 1 0 Voltage gated calcium channel subunit beta domain 4Aa N terminal Fijivirus_P9-2 PF06837.11 ETO29419.1 - 0.14 11.6 1.1 0.21 11.0 1.1 1.3 1 0 0 1 1 1 0 Fijivirus P9-2 protein Tcp10_C PF07202.13 ETO29420.1 - 4.2e-21 75.7 2.5 1.3e-15 57.8 1.3 2.1 1 1 1 2 2 2 2 T-complex protein 10 C-terminus DUF5613 PF18467.1 ETO29420.1 - 0.011 16.1 1.1 0.023 15.1 0.6 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF5613) Pallilysin PF18663.1 ETO29420.1 - 0.053 13.5 1.4 5.1 7.1 0.2 2.8 1 1 2 3 3 3 0 Pallilysin beta barrel domain Tetraspanin PF00335.20 ETO29421.1 - 0.068 12.9 2.8 0.072 12.8 0.0 2.4 2 0 0 2 2 2 0 Tetraspanin family DUF1664 PF07889.12 ETO29421.1 - 3.8 7.6 16.1 3 7.9 3.3 3.1 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Spherulin4 PF12138.8 ETO29423.1 - 0.013 15.2 1.9 0.015 15.0 1.9 1.1 1 0 0 1 1 1 0 Spherulation-specific family 4 Velvet PF11754.8 ETO29423.1 - 0.019 14.9 1.6 0.023 14.7 1.6 1.0 1 0 0 1 1 1 0 Velvet factor ECSIT PF06239.11 ETO29423.1 - 0.31 10.1 7.0 0.36 9.9 7.0 1.1 1 0 0 1 1 1 0 Evolutionarily conserved signalling intermediate in Toll pathway Presenilin PF01080.17 ETO29423.1 - 1.2 7.8 3.6 1.3 7.8 3.6 1.1 1 0 0 1 1 1 0 Presenilin DUF5427 PF10310.9 ETO29424.1 - 1.1 8.1 23.6 1.9 7.3 0.7 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5427) Sec62 PF03839.16 ETO29424.1 - 4.3 6.8 15.2 0.084 12.4 7.5 2.0 2 0 0 2 2 2 0 Translocation protein Sec62 TMEM192 PF14802.6 ETO29425.1 - 0.18 10.8 1.5 3.1 6.9 0.1 2.1 2 0 0 2 2 2 0 TMEM192 family SET PF00856.28 ETO29426.1 - 0.00018 21.9 0.0 0.00037 20.9 0.0 1.5 1 0 0 1 1 1 1 SET domain AWS PF17907.1 ETO29427.1 - 0.0095 16.0 4.6 0.018 15.1 4.6 1.4 1 0 0 1 1 1 1 AWS domain Pre-SET PF05033.16 ETO29427.1 - 3.6 8.3 11.5 1.7 9.3 8.4 2.0 2 0 0 2 2 2 0 Pre-SET motif IL6 PF00489.17 ETO29429.1 - 0.031 13.8 0.2 0.065 12.8 0.2 1.5 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family HpaB_N PF11794.8 ETO29429.1 - 0.14 11.8 0.3 0.26 10.9 0.3 1.4 1 0 0 1 1 1 0 4-hydroxyphenylacetate 3-hydroxylase N terminal Pox_C7_F8A PF03287.14 ETO29430.1 - 0.012 15.6 0.6 0.027 14.5 0.3 1.6 1 1 0 1 1 1 0 Poxvirus C7/F8A protein HECT PF00632.25 ETO29431.1 - 1e-36 127.0 0.0 1.2e-36 126.7 0.0 1.0 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) GED PF02212.18 ETO29431.1 - 0.042 14.0 0.5 0.088 13.0 0.0 1.7 2 0 0 2 2 2 0 Dynamin GTPase effector domain PIF3 PF05006.12 ETO29431.1 - 0.044 13.9 0.1 0.1 12.7 0.1 1.6 1 0 0 1 1 1 0 Per os infectivity factor 3 TPR_8 PF13181.6 ETO29432.1 - 8.1e-13 47.5 14.6 0.013 15.6 0.2 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29432.1 - 8.8e-12 44.2 17.0 0.024 14.7 0.2 5.9 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29432.1 - 2.1e-09 36.8 23.2 0.043 13.6 0.1 6.2 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO29432.1 - 7e-09 35.5 22.1 0.0086 16.4 0.1 7.8 5 2 3 8 8 8 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO29432.1 - 1.3e-08 35.0 23.6 8.9e-06 25.9 3.6 5.4 3 2 2 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO29432.1 - 4.7e-06 27.0 7.5 1.2 9.7 0.0 5.0 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO29432.1 - 6.2e-06 26.8 4.1 0.055 14.1 0.1 4.4 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29432.1 - 6.2e-06 25.9 6.6 0.0017 18.3 0.2 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29432.1 - 8e-06 25.4 20.0 0.0025 17.4 0.7 5.6 5 1 0 5 5 5 3 TPR repeat TPR_14 PF13428.6 ETO29432.1 - 2.8e-05 24.6 4.0 22 6.2 0.0 5.5 4 2 2 6 6 5 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29432.1 - 0.0051 16.6 17.3 0.0076 16.1 0.2 5.5 7 0 0 7 7 7 1 Tetratricopeptide repeat DUF3856 PF12968.7 ETO29432.1 - 0.77 9.8 4.6 4.5 7.3 0.0 3.4 3 1 1 4 4 4 0 Domain of Unknown Function (DUF3856) TPR_6 PF13174.6 ETO29432.1 - 9.2 7.2 7.6 24 5.9 0.1 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat PRNT PF15174.6 ETO29433.1 - 0.052 13.6 0.0 0.18 11.8 0.0 1.9 1 0 0 1 1 1 0 Prion-related protein testis-specific SANT_DAMP1_like PF16282.5 ETO29435.1 - 0.012 15.8 4.3 0.099 12.9 0.1 3.7 3 1 1 4 4 4 0 SANT/Myb-like domain of DAMP1 Pkinase PF00069.25 ETO29436.1 - 0.0012 18.3 0.1 0.0012 18.3 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain DUF1126 PF06565.12 ETO29438.1 - 3.7e-52 174.6 0.8 2.1e-26 91.8 0.0 2.4 2 0 0 2 2 2 2 DUF1126 PH-like domain EF-hand_8 PF13833.6 ETO29438.1 - 4.1e-06 26.5 0.0 1e-05 25.3 0.0 1.7 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO29438.1 - 1.2e-05 24.5 0.1 3.3e-05 23.1 0.1 1.9 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO29438.1 - 4e-05 23.2 0.1 0.00013 21.7 0.1 1.9 1 0 0 1 1 1 1 EF-hand domain EF-hand_7 PF13499.6 ETO29438.1 - 0.001 19.5 0.0 0.0037 17.7 0.0 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO29438.1 - 0.0013 18.1 0.1 0.0034 16.8 0.1 1.7 1 0 0 1 1 1 1 EF hand VMR2 PF17055.5 ETO29438.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 Viral matrix protein M2 VHS PF00790.19 ETO29439.1 - 0.00019 21.3 0.4 0.00074 19.4 0.1 2.2 2 1 0 2 2 2 1 VHS domain GAT PF03127.14 ETO29439.1 - 0.022 15.0 0.0 0.022 15.0 0.0 2.2 3 0 0 3 3 3 0 GAT domain Macoilin PF09726.9 ETO29439.1 - 0.93 8.0 14.2 1.3 7.5 14.2 1.2 1 0 0 1 1 1 0 Macoilin family VPS13_mid_rpt PF16910.5 ETO29441.1 - 1.1e-18 67.6 21.6 6.6e-08 32.3 0.2 6.3 6 1 0 6 6 6 4 Repeating coiled region of VPS13 VPS13 PF16908.5 ETO29441.1 - 2e-06 27.8 1.8 2e-06 27.8 1.8 4.8 4 1 2 6 6 6 1 Vacuolar sorting-associated protein 13, N-terminal Phage_Gp23 PF10669.9 ETO29441.1 - 0.032 14.6 2.8 0.11 12.8 2.3 2.2 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) VPS13_mid_rpt PF16910.5 ETO29442.1 - 0.00015 21.2 11.0 0.04 13.3 0.0 4.7 5 1 0 5 5 5 2 Repeating coiled region of VPS13 RhoGEF PF00621.20 ETO29444.1 - 2.1e-13 50.9 4.2 2.1e-13 50.9 4.2 2.2 2 0 0 2 2 2 1 RhoGEF domain PH PF00169.29 ETO29444.1 - 7.8e-09 36.0 5.7 0.011 16.2 0.2 3.4 1 1 2 3 3 3 3 PH domain Secretin_N_2 PF07655.13 ETO29444.1 - 0.012 16.1 6.8 0.034 14.7 6.8 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain IPT PF01745.16 ETO29444.1 - 0.019 14.3 0.2 0.029 13.8 0.2 1.3 1 0 0 1 1 1 0 Isopentenyl transferase PH_11 PF15413.6 ETO29444.1 - 0.027 14.9 11.7 0.097 13.1 7.9 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain PH_16 PF17838.1 ETO29444.1 - 0.13 12.1 0.1 0.13 12.1 0.1 2.2 3 1 0 3 3 3 0 PH domain p450 PF00067.22 ETO29445.1 - 4.1e-53 180.8 0.7 4.9e-53 180.5 0.7 1.0 1 0 0 1 1 1 1 Cytochrome P450 DTHCT PF08070.11 ETO29446.1 - 5.5 7.8 47.2 0.063 14.0 8.3 2.2 2 0 0 2 2 2 0 DTHCT (NUC029) region DUF936 PF06075.12 ETO29446.1 - 7.7 5.3 32.9 8.4 5.2 32.9 1.0 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) EMP70 PF02990.16 ETO29447.1 - 2.9e-76 257.2 31.6 4.3e-76 256.6 31.6 1.3 1 0 0 1 1 1 1 Endomembrane protein 70 CBP_BcsF PF11120.8 ETO29447.1 - 0.73 10.0 0.1 0.73 10.0 0.1 3.0 4 0 0 4 4 4 0 Cellulose biosynthesis protein BcsF EMP70 PF02990.16 ETO29448.1 - 3.7e-33 115.0 0.4 4.5e-33 114.7 0.4 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 ECF_trnsprt PF12822.7 ETO29448.1 - 0.3 11.2 3.0 0.31 11.1 0.4 1.8 1 1 1 2 2 2 0 ECF transporter, substrate-specific component IZUMO PF15005.6 ETO29450.1 - 0.0049 17.4 0.5 0.0086 16.6 0.5 1.4 1 0 0 1 1 1 1 Izumo sperm-egg fusion, Ig domain-associated RasGAP_C PF03836.15 ETO29450.1 - 1.3 9.2 3.8 1.7 8.8 0.3 2.4 2 1 1 3 3 3 0 RasGAP C-terminus RGS PF00615.19 ETO29451.1 - 8.8e-08 32.4 0.6 2.2e-07 31.2 0.6 1.7 1 0 0 1 1 1 1 Regulator of G protein signaling domain DUF4834 PF16118.5 ETO29454.1 - 6.7 7.7 0.0 6.7 7.7 0.0 3.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) EIF_2_alpha PF07541.12 ETO29455.1 - 1.2e-31 109.2 0.0 2.3e-31 108.3 0.0 1.5 1 0 0 1 1 1 1 Eukaryotic translation initiation factor 2 alpha subunit S1 PF00575.23 ETO29455.1 - 3.9e-10 39.9 0.5 7e-10 39.1 0.5 1.4 1 0 0 1 1 1 1 S1 RNA binding domain DUF3591 PF12157.8 ETO29455.1 - 0.017 13.8 0.1 0.022 13.4 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3591) Ribosomal_S19e PF01090.19 ETO29455.1 - 0.093 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S19e G-alpha PF00503.20 ETO29457.1 - 9.6e-34 117.1 0.1 1.1e-33 116.9 0.1 1.0 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO29457.1 - 0.00031 21.3 0.3 0.0005 20.6 0.3 1.2 1 0 0 1 1 1 1 ABC transporter AAA_16 PF13191.6 ETO29457.1 - 0.0041 17.5 0.0 0.0046 17.4 0.0 1.1 1 0 0 1 1 1 1 AAA ATPase domain AAA_29 PF13555.6 ETO29457.1 - 0.008 15.9 0.1 0.014 15.2 0.1 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain Mg_chelatase PF01078.21 ETO29457.1 - 0.022 14.1 0.0 0.039 13.3 0.0 1.4 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 ETO29457.1 - 0.034 13.5 0.0 0.054 12.8 0.0 1.2 1 0 0 1 1 1 0 FtsK/SpoIIIE family SMC_N PF02463.19 ETO29457.1 - 0.084 12.3 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF4994 PF16385.5 ETO29460.1 - 0.15 12.0 0.0 0.22 11.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function CPSF73-100_C PF11718.8 ETO29461.1 - 1.7e-06 27.8 3.1 0.00024 20.7 3.2 2.9 2 1 0 2 2 2 2 Pre-mRNA 3'-end-processing endonuclease polyadenylation factor C-term TPR_17 PF13431.6 ETO29462.1 - 2.1e-26 90.4 23.2 0.00015 21.9 0.2 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29462.1 - 8.4e-22 76.6 18.8 0.00034 20.2 0.3 6.9 5 2 2 7 7 7 5 TPR repeat TPR_8 PF13181.6 ETO29462.1 - 1.4e-20 71.7 21.4 2.8e-07 30.2 0.1 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29462.1 - 6.5e-20 70.1 27.7 1.4e-07 31.1 0.1 8.0 8 1 0 8 8 8 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29462.1 - 2.9e-17 61.3 29.7 4.2e-07 29.6 0.0 8.6 8 1 0 8 8 8 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO29462.1 - 2.1e-15 57.1 4.2 0.014 16.1 0.0 5.3 3 1 3 6 6 6 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO29462.1 - 9e-15 54.7 22.1 5.3e-06 26.6 0.1 5.1 3 2 1 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO29462.1 - 2.5e-12 46.5 4.2 0.0047 17.6 0.0 5.5 4 2 1 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29462.1 - 1.5e-11 43.7 18.1 3e-05 23.7 0.1 5.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29462.1 - 5.1e-10 38.7 17.4 0.0015 18.4 0.0 6.6 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO29462.1 - 1.5e-08 35.0 11.8 0.041 14.4 0.0 5.2 3 1 1 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO29462.1 - 0.00032 21.1 5.4 4.4 8.1 0.0 4.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TOM20_plant PF06552.12 ETO29462.1 - 0.0078 16.0 0.4 6.3 6.5 0.2 3.3 2 1 1 3 3 3 1 Plant specific mitochondrial import receptor subunit TOM20 DHHA2 PF02833.14 ETO29462.1 - 0.0078 16.4 0.2 0.016 15.4 0.0 1.7 2 1 0 2 2 2 1 DHHA2 domain Fis1_TPR_C PF14853.6 ETO29462.1 - 0.69 10.0 9.6 8.6 6.5 0.2 4.1 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat DUF5000 PF16391.5 ETO29464.1 - 0.0089 16.2 4.7 0.017 15.3 4.7 1.5 1 0 0 1 1 1 1 Domain of unknown function ROF PF07073.12 ETO29464.1 - 0.049 13.8 0.6 0.13 12.4 0.6 1.7 1 0 0 1 1 1 0 Modulator of Rho-dependent transcription termination (ROF) Orf78 PF06024.12 ETO29467.1 - 0.0056 17.0 2.0 0.017 15.4 2.0 1.8 1 0 0 1 1 1 1 Orf78 (ac78) Chorion_3 PF05387.11 ETO29467.1 - 2.7 7.6 4.8 4.9 6.7 4.8 1.3 1 0 0 1 1 1 0 Chorion family 3 GATase PF00117.28 ETO29471.1 - 0.0001 22.1 0.0 0.00014 21.7 0.0 1.2 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO29471.1 - 0.00084 19.2 0.0 0.00098 18.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase C26 Nucleic_acid_bd PF13820.6 ETO29471.1 - 0.0016 18.3 0.1 0.13 12.1 0.2 2.1 1 1 1 2 2 2 2 Putative nucleic acid-binding region Vps53_N PF04100.12 ETO29473.1 - 0.044 12.8 0.1 0.089 11.7 0.0 1.5 2 0 0 2 2 2 0 Vps53-like, N-terminal WD40 PF00400.32 ETO29474.1 - 4.1e-26 90.7 19.6 2.9e-05 24.7 0.3 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO29474.1 - 7.8e-05 21.5 4.3 0.31 9.6 0.1 4.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO29474.1 - 0.00039 20.7 0.8 5.2 7.4 0.0 4.3 2 1 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Head_binding PF09008.10 ETO29474.1 - 1.3 9.3 6.8 11 6.3 0.3 3.1 3 0 0 3 3 3 0 Head binding Peptidase_C14 PF00656.22 ETO29475.1 - 3.7e-06 27.1 0.2 9e-06 25.8 0.2 1.6 1 0 0 1 1 1 1 Caspase domain DUF4349 PF14257.6 ETO29476.1 - 0.087 12.3 1.6 0.13 11.6 0.9 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4349) TCTP PF00838.17 ETO29476.1 - 1.7 8.9 12.9 0.67 10.3 8.1 2.4 1 1 1 2 2 2 0 Translationally controlled tumour protein Secretin_N_2 PF07655.13 ETO29477.1 - 1.5 9.4 23.0 2.8 8.5 5.9 3.4 3 0 0 3 3 3 0 Secretin N-terminal domain DUF724 PF05266.14 ETO29478.1 - 0.037 13.9 3.8 0.11 12.4 3.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF724) PIG-S PF10510.9 ETO29478.1 - 0.048 12.5 3.4 0.089 11.6 3.4 1.4 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein PIN_4 PF13638.6 ETO29478.1 - 0.32 11.3 5.3 0.097 13.0 1.0 2.3 3 0 0 3 3 3 0 PIN domain Glyco_hydro_38C PF07748.13 ETO29479.1 - 4.6e-21 75.9 1.1 3.5e-20 73.0 0.1 2.1 1 1 0 2 2 2 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro38C2 PF17677.1 ETO29479.1 - 0.14 12.3 0.0 0.33 11.1 0.0 1.8 1 1 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain Spc7 PF08317.11 ETO29480.1 - 0.00087 18.3 78.1 0.0016 17.4 29.6 4.0 2 1 2 4 4 4 3 Spc7 kinetochore protein CENP-F_leu_zip PF10473.9 ETO29480.1 - 0.0016 18.5 82.0 1.1 9.3 17.5 5.5 2 2 3 5 5 5 5 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 ETO29480.1 - 0.0074 15.7 80.7 0.21 10.9 23.1 3.9 1 1 2 3 3 3 3 Growth-arrest specific micro-tubule binding TMF_TATA_bd PF12325.8 ETO29480.1 - 0.015 15.5 19.3 0.015 15.5 19.3 5.5 2 2 3 5 5 5 0 TATA element modulatory factor 1 TATA binding Snapin_Pallidin PF14712.6 ETO29480.1 - 0.016 15.6 8.9 0.016 15.6 8.9 5.8 3 1 2 6 6 5 0 Snapin/Pallidin APG6_N PF17675.1 ETO29480.1 - 0.051 14.1 78.6 0.3 11.6 13.9 5.2 2 1 3 5 5 5 0 Apg6 coiled-coil region FUSC PF04632.12 ETO29480.1 - 0.076 11.5 14.7 0.91 8.0 3.0 2.8 1 1 2 3 3 3 0 Fusaric acid resistance protein family DUF1664 PF07889.12 ETO29480.1 - 0.17 11.9 59.1 0.033 14.2 7.6 6.0 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) Fez1 PF06818.15 ETO29480.1 - 0.61 10.5 65.4 3.4 8.1 24.6 3.5 1 1 2 3 3 3 0 Fez1 ATG16 PF08614.11 ETO29480.1 - 1.2 9.3 73.1 0.029 14.6 26.8 4.4 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) Taxilin PF09728.9 ETO29480.1 - 1.5 7.9 78.6 0.26 10.4 23.6 3.9 2 1 0 2 2 2 0 Myosin-like coiled-coil protein KASH_CCD PF14662.6 ETO29480.1 - 2.5 7.9 76.5 7.7 6.3 30.2 3.9 1 1 2 3 3 3 0 Coiled-coil region of CCDC155 or KASH Exonuc_VII_S PF02609.16 ETO29480.1 - 6.3 6.9 14.7 0.79 9.8 0.7 4.0 4 0 0 4 4 4 0 Exonuclease VII small subunit ERM PF00769.19 ETO29480.1 - 8.9 6.0 73.0 0.16 11.7 23.8 3.3 2 1 0 3 3 3 0 Ezrin/radixin/moesin family Phage_GP20 PF06810.11 ETO29480.1 - 9.6 6.0 70.9 0.067 13.0 23.7 5.0 3 1 2 5 5 5 0 Phage minor structural protein GP20 TPR_11 PF13414.6 ETO29481.1 - 0.0014 18.3 0.1 0.0035 17.0 0.1 1.7 1 0 0 1 1 1 1 TPR repeat TPR_1 PF00515.28 ETO29481.1 - 0.0037 17.0 0.2 0.018 14.9 0.1 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29481.1 - 0.016 15.3 1.7 0.11 12.7 0.1 3.2 3 1 1 4 4 4 0 Tetratricopeptide repeat Lzipper-MIP1 PF14389.6 ETO29481.1 - 0.024 14.9 2.2 0.035 14.4 0.1 2.5 2 0 0 2 2 2 0 Leucine-zipper of ternary complex factor MIP1 PSDC PF12588.8 ETO29481.1 - 0.065 13.2 0.4 0.26 11.3 0.4 2.0 1 0 0 1 1 1 0 Phophatidylserine decarboxylase DUF1664 PF07889.12 ETO29481.1 - 0.1 12.6 10.5 4.6 7.3 2.2 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) Csm1_N PF18504.1 ETO29481.1 - 0.12 12.7 5.2 0.095 13.1 2.2 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain CLZ PF16526.5 ETO29481.1 - 1.8 9.0 6.3 1.6 9.1 0.5 3.1 3 0 0 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF2089 PF09862.9 ETO29481.1 - 1.9 8.5 4.9 1.1 9.3 0.1 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF2089) TPR_11 PF13414.6 ETO29482.1 - 5.3e-10 38.8 17.2 0.0011 18.6 1.3 3.5 1 1 2 3 3 3 3 TPR repeat TPR_8 PF13181.6 ETO29482.1 - 8.7e-07 28.7 6.7 0.032 14.4 2.6 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29482.1 - 5.7e-06 26.0 18.4 0.026 14.6 1.1 4.1 3 2 0 3 3 3 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO29482.1 - 1.2e-05 25.7 5.7 0.029 15.2 0.4 3.5 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO29482.1 - 1.7e-05 24.9 17.3 0.00024 21.3 2.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29482.1 - 5.8e-05 22.7 15.4 0.0097 15.7 0.1 4.4 3 1 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO29482.1 - 0.0017 18.8 10.5 0.22 12.1 3.6 2.4 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO29482.1 - 0.0044 17.6 10.9 1.4 9.7 3.5 3.4 2 2 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO29482.1 - 0.0049 17.1 14.3 0.032 14.5 3.0 2.9 1 1 1 2 2 2 1 Tetratricopeptide repeat FAT PF02259.23 ETO29482.1 - 0.015 14.5 2.4 0.02 14.1 2.4 1.3 1 0 0 1 1 1 0 FAT domain TPR_9 PF13371.6 ETO29482.1 - 0.078 13.1 3.1 0.2 11.8 0.2 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat DUF3461 PF11944.8 ETO29482.1 - 0.12 12.5 0.3 0.24 11.5 0.3 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3461) Fis1_TPR_C PF14853.6 ETO29482.1 - 0.37 10.9 7.5 1.2 9.2 0.3 3.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat SHNi-TPR PF10516.9 ETO29482.1 - 9.1 5.8 8.2 11 5.6 0.5 2.8 3 0 0 3 3 3 0 SHNi-TPR WD40 PF00400.32 ETO29483.1 - 2.7e-08 34.3 16.6 0.0017 19.2 0.1 5.5 6 0 0 6 6 6 3 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO29483.1 - 0.013 14.2 0.8 0.83 8.3 0.0 2.4 2 1 0 2 2 2 0 Nup133 N terminal like DUF374 PF04028.13 ETO29483.1 - 0.047 13.3 0.1 2.6 7.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF374) DUF4201 PF13870.6 ETO29484.1 - 0.028 14.2 28.6 0.12 12.1 12.7 3.4 2 1 0 3 3 3 0 Domain of unknown function (DUF4201) DUF5320 PF17253.2 ETO29484.1 - 0.22 12.6 0.0 0.22 12.6 0.0 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5320) Fez1 PF06818.15 ETO29484.1 - 0.42 11.0 17.6 1.7 9.0 10.0 2.7 1 1 0 2 2 2 0 Fez1 DivIC PF04977.15 ETO29484.1 - 0.71 9.7 25.3 3.2 7.6 1.5 5.2 5 0 0 5 5 5 0 Septum formation initiator PKcGMP_CC PF16808.5 ETO29484.1 - 1 9.3 13.2 1.5 8.8 1.8 3.7 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DDE_Tnp_1_3 PF13612.6 ETO29484.1 - 3.4 7.7 7.2 0.37 10.8 0.9 2.2 1 1 1 2 2 2 0 Transposase DDE domain Tropomyosin_1 PF12718.7 ETO29484.1 - 8.9 6.5 24.3 3.3 7.9 2.1 4.0 4 0 0 4 4 4 0 Tropomyosin like Kinesin PF00225.23 ETO29485.1 - 9.3e-15 54.4 2.8 9.3e-15 54.4 2.8 2.0 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO29485.1 - 2.2e-09 37.4 3.4 4e-09 36.6 0.2 2.4 2 0 0 2 2 2 1 Microtubule binding Hydin_ADK PF17213.3 ETO29485.1 - 0.012 15.9 1.6 0.024 14.9 1.6 1.6 1 1 0 1 1 1 0 Hydin Adenylate kinase-like domain AAA_24 PF13479.6 ETO29485.1 - 0.04 13.6 0.0 0.065 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain Ank_2 PF12796.7 ETO29486.1 - 9.2e-06 26.2 0.1 4.2e-05 24.0 0.1 2.2 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO29486.1 - 2.9e-05 24.1 0.0 0.058 14.0 0.0 3.1 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETO29486.1 - 5.8e-05 23.6 0.1 0.0012 19.4 0.1 2.7 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO29486.1 - 0.00036 20.8 0.0 0.0013 19.0 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO29486.1 - 0.06 13.8 0.0 3.9 8.1 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat Peptidase_S76 PF13611.6 ETO29486.1 - 1.1 9.7 6.7 0.17 12.2 1.7 2.4 2 0 0 2 2 2 0 Serine peptidase of plant viral polyprotein, P1 Tubulin PF00091.25 ETO29488.1 - 3.6e-38 131.8 0.1 6.9e-38 130.8 0.1 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO29488.1 - 1.2e-25 90.1 0.7 3.4e-21 75.7 0.3 2.3 2 0 0 2 2 2 2 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO29488.1 - 0.0063 15.7 0.5 0.013 14.7 0.5 1.7 1 1 0 1 1 1 1 Tubulin like Thiolase_C PF02803.18 ETO29489.1 - 3.3e-41 139.8 0.0 5.7e-41 139.0 0.0 1.3 1 0 0 1 1 1 1 Thiolase, C-terminal domain Thiolase_N PF00108.23 ETO29489.1 - 5.2e-27 94.8 1.1 7.7e-15 54.9 0.1 2.1 2 0 0 2 2 2 2 Thiolase, N-terminal domain Chorion_2 PF03964.15 ETO29490.1 - 0.00061 20.6 2.3 0.0013 19.6 2.3 1.5 1 0 0 1 1 1 1 Chorion family 2 Herpes_pp85 PF04637.12 ETO29490.1 - 0.00081 17.9 4.0 0.0011 17.4 4.0 1.1 1 0 0 1 1 1 1 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Ndc1_Nup PF09531.10 ETO29490.1 - 0.073 11.7 5.0 0.075 11.7 5.0 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Apt1 PF10351.9 ETO29490.1 - 0.21 10.4 10.5 0.24 10.2 10.5 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SR-25 PF10500.9 ETO29490.1 - 0.49 10.0 31.6 41 3.7 31.6 2.1 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Presenilin PF01080.17 ETO29490.1 - 0.91 8.2 8.5 1.1 7.9 8.5 1.1 1 0 0 1 1 1 0 Presenilin EBP50_C PF09007.11 ETO29490.1 - 0.92 10.5 20.9 43 5.1 20.9 2.2 1 1 0 1 1 1 0 EBP50, C-terminal MRP-L47 PF06984.13 ETO29491.1 - 0.0026 17.8 0.7 0.0026 17.8 0.7 2.2 2 1 0 2 2 2 1 Mitochondrial 39-S ribosomal protein L47 (MRP-L47) CCER1 PF15482.6 ETO29492.1 - 0.0082 16.1 1.8 0.0082 16.1 1.8 1.5 2 0 0 2 2 2 1 Coiled-coil domain-containing glutamate-rich protein family 1 SAM_1 PF00536.30 ETO29493.1 - 6e-10 39.4 0.0 1.2e-09 38.5 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO29493.1 - 1.5e-09 37.8 0.0 7.2e-09 35.6 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 ETO29493.1 - 0.0028 17.4 0.2 0.0055 16.5 0.2 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO29493.1 - 0.023 14.6 0.4 0.05 13.6 0.4 1.6 1 1 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain Fur_reg_FbpA PF13076.6 ETO29493.1 - 0.028 14.1 0.3 0.047 13.4 0.3 1.4 1 0 0 1 1 1 0 Fur-regulated basic protein A Img2 PF05046.14 ETO29493.1 - 0.065 13.5 0.1 0.16 12.3 0.0 1.7 2 0 0 2 2 2 0 Mitochondrial large subunit ribosomal protein (Img2) IclR PF01614.18 ETO29494.1 - 0.17 11.7 0.0 0.46 10.3 0.0 1.7 2 0 0 2 2 2 0 Bacterial transcriptional regulator IFT57 PF10498.9 ETO29495.1 - 0.00013 21.1 27.0 0.00016 20.8 27.0 1.0 1 0 0 1 1 1 1 Intra-flagellar transport protein 57 ATG16 PF08614.11 ETO29495.1 - 0.0056 16.9 26.7 0.0076 16.5 26.7 1.2 1 0 0 1 1 1 1 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 ETO29495.1 - 0.027 14.7 7.4 0.027 14.7 7.4 2.6 1 1 1 2 2 1 0 TATA element modulatory factor 1 TATA binding DUF948 PF06103.11 ETO29495.1 - 0.33 11.2 2.2 0.65 10.3 2.2 1.6 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Exonuc_VII_L PF02601.15 ETO29495.1 - 1.2 8.6 21.5 1.6 8.2 21.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit PIN_9 PF18477.1 ETO29495.1 - 1.5 9.2 6.2 1.1 9.6 4.0 1.9 1 1 1 2 2 2 0 PIN like domain DUF4407 PF14362.6 ETO29495.1 - 1.6 8.0 19.9 2.2 7.6 19.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF1664 PF07889.12 ETO29495.1 - 3.3 7.8 16.5 4.2 7.4 1.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Spc7 PF08317.11 ETO29495.1 - 5.3 5.8 34.5 0.089 11.7 11.2 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein Atg14 PF10186.9 ETO29495.1 - 7.4 5.5 31.6 2.8e+02 0.4 31.7 2.1 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF730 PF05325.11 ETO29495.1 - 8.7 6.4 11.5 0.12 12.3 3.2 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF730) SHE3 PF17078.5 ETO29496.1 - 0.0057 16.4 4.3 0.0066 16.2 4.3 1.1 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 Guanylate_cyc_2 PF09778.9 ETO29496.1 - 0.031 13.6 0.6 0.048 13.0 0.6 1.2 1 0 0 1 1 1 0 Guanylylate cyclase DUF4201 PF13870.6 ETO29496.1 - 0.065 13.0 9.9 0.15 11.8 9.7 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4201) DUF2207 PF09972.9 ETO29496.1 - 0.081 11.7 1.0 0.091 11.5 1.0 1.0 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2852 PF11014.8 ETO29496.1 - 0.13 12.4 0.8 0.2 11.8 0.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Atg14 PF10186.9 ETO29496.1 - 0.23 10.5 5.2 0.3 10.1 5.2 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Csm1_N PF18504.1 ETO29496.1 - 1.5 9.2 10.5 1.1 9.6 3.5 2.2 1 1 1 2 2 2 0 Csm1 N-terminal domain APG6_N PF17675.1 ETO29496.1 - 3.8 8.1 14.6 6.4 7.3 14.6 1.3 1 1 0 1 1 1 0 Apg6 coiled-coil region ZapB PF06005.12 ETO29496.1 - 6 7.4 12.3 19 5.8 1.7 2.1 1 1 1 2 2 2 0 Cell division protein ZapB DUF3450 PF11932.8 ETO29496.1 - 9.3 5.5 10.9 10 5.3 0.4 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Kelch_2 PF07646.15 ETO29497.1 - 2.3e-05 24.2 2.7 0.38 10.8 0.4 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO29497.1 - 7.6e-05 22.6 0.5 1.1 9.3 0.1 4.5 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO29497.1 - 0.00011 22.3 3.2 1.4 9.4 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO29497.1 - 0.0038 16.8 3.6 0.043 13.4 0.2 3.3 3 0 0 3 3 3 1 Kelch motif NCBP3 PF10309.9 ETO29497.1 - 0.045 13.6 0.8 0.12 12.3 0.8 1.7 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 Mei4 PF13971.6 ETO29498.1 - 0.011 15.2 0.2 0.014 14.9 0.2 1.3 1 0 0 1 1 1 0 Meiosis-specific protein Mei4 SRP54_N PF02881.19 ETO29498.1 - 0.044 14.0 0.1 2 8.7 0.0 2.4 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain DUF667 PF05018.13 ETO29500.1 - 1.8e-56 190.8 0.9 1.8e-56 190.8 0.9 1.4 2 0 0 2 2 2 1 Protein of unknown function (DUF667) Pox_A30L_A26L PF06086.12 ETO29500.1 - 0.38 10.4 5.5 0.21 11.2 2.2 1.8 1 1 1 2 2 2 0 Orthopoxvirus A26L/A30L protein DUF5338 PF17273.2 ETO29501.1 - 0.34 11.0 0.1 0.34 11.0 0.1 2.7 4 0 0 4 4 4 0 Family of unknown function (DUF5338) STAG PF08514.11 ETO29502.1 - 0.00012 22.0 0.2 0.00012 22.0 0.2 4.5 4 1 1 5 5 5 1 STAG domain WD40 PF00400.32 ETO29504.1 - 1.8e-65 215.3 18.9 7.7e-09 36.1 0.1 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29504.1 - 5.4e-23 81.1 0.4 0.0022 18.2 0.0 6.3 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29504.1 - 2.9e-14 52.8 0.1 0.013 14.5 0.0 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO29504.1 - 4.8e-09 36.4 0.2 0.052 13.4 0.4 3.8 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO29504.1 - 2.3e-07 29.8 2.5 1.5 7.4 0.0 6.3 2 2 5 7 7 7 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29504.1 - 3.8e-06 26.4 0.1 0.013 14.8 0.0 3.0 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO29504.1 - 8.4e-05 22.4 14.7 2.2 8.3 0.0 6.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO29504.1 - 0.00015 21.2 2.4 4.2 6.6 0.0 4.2 2 2 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO29504.1 - 0.0016 17.2 5.7 1.7 7.3 0.1 4.3 2 2 1 3 3 3 1 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO29504.1 - 0.0072 14.9 0.8 4.8 5.6 0.0 3.4 2 1 2 4 4 4 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO29504.1 - 0.011 15.4 1.0 0.29 10.7 0.2 2.7 2 1 0 3 3 3 0 PQQ-like domain DUF5570 PF17731.1 ETO29504.1 - 0.019 15.1 2.7 48 4.1 0.0 4.7 4 2 2 6 6 6 0 Family of unknown function (DUF5570) DUF2963 PF11178.8 ETO29504.1 - 0.019 14.6 0.1 22 4.8 0.0 4.0 3 1 0 3 3 3 0 Protein of unknown function (DUF2963) Vac_Fusion PF02346.16 ETO29504.1 - 0.025 14.2 0.2 3.9 7.2 0.0 3.3 3 0 0 3 3 3 0 Chordopoxvirus multifunctional envelope protein A27 DUF1797 PF08796.10 ETO29504.1 - 0.03 14.4 0.0 0.32 11.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) PQQ PF01011.21 ETO29504.1 - 0.042 13.8 0.0 75 3.5 0.0 3.8 3 0 0 3 3 3 0 PQQ enzyme repeat NHL PF01436.21 ETO29504.1 - 0.11 12.5 0.0 15 5.9 0.0 3.4 3 0 0 3 3 3 0 NHL repeat WD40 PF00400.32 ETO29505.1 - 1e-55 184.4 16.7 3.8e-09 37.0 0.4 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29505.1 - 9.2e-22 77.2 2.7 0.0076 16.5 0.0 7.2 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29505.1 - 4.4e-19 68.6 0.7 0.007 15.4 0.0 6.8 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29505.1 - 6.3e-09 35.6 2.0 0.16 11.3 0.2 4.0 1 1 3 4 4 4 4 WD40-like domain Cytochrom_D1 PF02239.16 ETO29505.1 - 1e-07 30.8 0.5 0.031 12.8 0.1 3.2 1 1 1 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO29505.1 - 1.1e-07 31.6 4.0 3.4 7.7 0.1 6.0 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO29505.1 - 0.00054 19.4 1.2 1.3 8.2 0.0 4.0 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Gmad1 PF10647.9 ETO29505.1 - 0.0032 17.2 0.0 2.1 8.0 0.0 2.6 2 1 0 2 2 2 2 Lipoprotein LpqB beta-propeller domain Proteasome_A_N PF10584.9 ETO29505.1 - 0.0033 17.1 2.1 36 4.2 0.0 5.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO29505.1 - 0.15 12.0 0.0 80 3.4 0.0 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat Macro PF01661.21 ETO29507.1 - 1.3e-38 131.7 0.1 2.1e-38 131.0 0.1 1.3 1 0 0 1 1 1 1 Macro domain DUF1281_C PF18406.1 ETO29508.1 - 0.53 10.0 4.0 3.1 7.6 0.1 2.5 2 1 0 2 2 2 0 Ferredoxin-like domain in Api92-like protein SWIB PF02201.18 ETO29509.1 - 0.00031 20.6 0.1 0.00058 19.7 0.1 1.4 1 0 0 1 1 1 1 SWIB/MDM2 domain Connexin PF00029.19 ETO29510.1 - 0.3 10.8 13.9 0.071 12.9 1.2 2.1 2 0 0 2 2 2 0 Connexin FGF-BP1 PF06473.12 ETO29510.1 - 4.4 7.1 27.3 5.3 6.8 9.9 2.1 2 0 0 2 2 2 0 FGF binding protein 1 (FGF-BP1) RNA_pol_Rpc4 PF05132.14 ETO29510.1 - 5.1 7.5 27.3 6.9 7.1 12.6 2.2 2 0 0 2 2 2 0 RNA polymerase III RPC4 AP3D1 PF06375.11 ETO29511.1 - 0.057 13.7 11.6 0.093 13.0 11.6 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 DUF4337 PF14235.6 ETO29511.1 - 0.45 10.6 5.4 0.69 10.0 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Med19 PF10278.9 ETO29511.1 - 0.63 9.9 13.4 0.98 9.3 13.4 1.2 1 0 0 1 1 1 0 Mediator of RNA pol II transcription subunit 19 Presenilin PF01080.17 ETO29511.1 - 1.8 7.3 4.2 1.7 7.4 4.2 1.2 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 ETO29511.1 - 3.4 7.4 5.8 5.6 6.7 5.8 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Vpu PF00558.19 ETO29511.1 - 8.1 6.3 7.2 8.8 6.2 5.2 2.1 2 0 0 2 2 2 0 Vpu protein Pyridoxal_deC PF00282.19 ETO29512.1 - 2.4e-08 33.1 0.0 3.8e-08 32.4 0.0 1.3 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain BatD PF13584.6 ETO29512.1 - 0.051 12.4 0.0 0.065 12.0 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance SDA1 PF05285.12 ETO29514.1 - 0.0029 17.1 19.1 0.0044 16.5 19.1 1.3 1 0 0 1 1 1 1 SDA1 DUF4746 PF15928.5 ETO29514.1 - 0.053 12.9 14.0 0.1 12.0 14.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Mur_ligase PF01225.25 ETO29514.1 - 0.073 13.4 0.1 0.22 11.9 0.1 1.8 1 0 0 1 1 1 0 Mur ligase family, catalytic domain Nop14 PF04147.12 ETO29514.1 - 0.11 10.6 18.7 0.16 10.1 18.7 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_pol_3_Rpc31 PF11705.8 ETO29514.1 - 0.15 12.3 17.6 0.27 11.4 17.6 1.4 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 DUF1840 PF08895.11 ETO29514.1 - 0.17 12.3 7.2 0.08 13.3 4.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) zf-Di19 PF05605.12 ETO29514.1 - 0.22 11.8 1.2 0.56 10.6 1.2 1.7 1 0 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding BUD22 PF09073.10 ETO29514.1 - 0.34 10.2 18.5 0.51 9.6 18.5 1.2 1 0 0 1 1 1 0 BUD22 CobT PF06213.12 ETO29514.1 - 0.58 9.5 20.1 0.91 8.9 20.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT OMP_b-brl_3 PF14905.6 ETO29514.1 - 0.59 9.0 22.6 0.1 11.6 11.0 2.1 2 0 0 2 2 2 0 Outer membrane protein beta-barrel family DUF4471 PF14740.6 ETO29514.1 - 0.68 9.1 12.6 0.083 12.1 4.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4471) RNA_polI_A34 PF08208.11 ETO29514.1 - 1.3 9.0 14.6 2.1 8.4 14.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NOA36 PF06524.12 ETO29514.1 - 3.4 6.9 17.8 10 5.3 17.8 1.8 1 0 0 1 1 1 0 NOA36 protein Tim54 PF11711.8 ETO29514.1 - 8.8 5.0 13.2 16 4.2 13.2 1.5 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Xpo1 PF08389.12 ETO29515.1 - 0.31 11.1 4.3 0.11 12.6 1.3 1.7 2 1 0 2 2 2 0 Exportin 1-like protein SOBP PF15279.6 ETO29516.1 - 0.071 13.7 4.8 0.1 13.2 4.8 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein RNA_polI_A34 PF08208.11 ETO29516.1 - 0.14 12.2 33.0 0.16 12.1 6.3 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 TMEM215 PF15746.5 ETO29516.1 - 0.55 9.7 4.9 0.98 8.8 4.9 1.4 1 0 0 1 1 1 0 TMEM215 family Peptidase_A21 PF03566.13 ETO29516.1 - 2 6.6 5.2 2.4 6.3 5.2 1.1 1 0 0 1 1 1 0 Peptidase family A21 SID-1_RNA_chan PF13965.6 ETO29516.1 - 2 6.7 5.0 2.6 6.3 5.0 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4604 PF15377.6 ETO29516.1 - 3 8.2 34.2 1.7 9.0 6.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) GEN1_C PF18380.1 ETO29516.1 - 7.1 7.6 16.8 4.3 8.3 4.0 2.4 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Kelch_1 PF01344.25 ETO29517.1 - 2e-05 24.1 3.3 0.00054 19.5 1.0 3.2 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO29517.1 - 0.00052 20.0 0.4 0.0017 18.3 0.1 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29517.1 - 0.00053 19.9 6.4 0.016 15.1 0.4 3.8 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO29517.1 - 0.00056 20.1 5.0 0.41 11.0 0.8 4.0 4 1 1 5 5 5 2 Kelch motif DUF4087 PF13316.6 ETO29517.1 - 0.051 14.1 0.5 0.14 12.7 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF4087) Kelch_5 PF13854.6 ETO29517.1 - 4.8 7.3 7.4 6.5 6.9 1.4 3.6 4 1 1 5 5 5 0 Kelch motif Gasdermin PF04598.12 ETO29520.1 - 0.0072 15.8 0.4 0.0098 15.3 0.4 1.2 1 0 0 1 1 1 1 Gasdermin pore forming domain HTH_48 PF17906.1 ETO29520.1 - 0.015 15.4 1.6 0.027 14.6 1.0 1.8 2 0 0 2 2 2 0 HTH domain in Mos1 transposase DUF4047 PF13256.6 ETO29520.1 - 0.13 12.4 2.6 0.16 12.1 0.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4047) Methyltransf_25 PF13649.6 ETO29521.1 - 2.1e-08 34.8 0.0 4.8e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ETO29521.1 - 2.1e-08 33.9 0.1 5.1e-08 32.7 0.0 1.7 2 0 0 2 2 2 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_11 PF08241.12 ETO29521.1 - 5.4e-07 30.2 0.0 1.5e-06 28.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO29521.1 - 8.5e-07 28.9 0.1 1.8e-06 27.8 0.0 1.7 1 1 0 1 1 1 1 Methyltransferase domain PRMT5 PF05185.16 ETO29521.1 - 2.1e-05 24.4 0.0 4e-05 23.5 0.0 1.4 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase Methyltransf_23 PF13489.6 ETO29521.1 - 4.2e-05 23.4 0.0 8.7e-05 22.4 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_9 PF08003.11 ETO29521.1 - 0.0024 16.9 0.0 0.0033 16.4 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1698) MTS PF05175.14 ETO29521.1 - 0.0025 17.4 0.1 0.0048 16.5 0.1 1.4 1 0 0 1 1 1 1 Methyltransferase small domain CMAS PF02353.20 ETO29521.1 - 0.0028 17.0 0.0 0.0041 16.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase DOT1 PF08123.13 ETO29521.1 - 0.003 17.1 0.1 0.0093 15.5 0.1 1.8 1 0 0 1 1 1 1 Histone methylation protein DOT1 Methyltransf_12 PF08242.12 ETO29521.1 - 0.0051 17.5 0.0 0.012 16.3 0.0 1.7 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ETO29521.1 - 0.015 15.0 0.0 0.024 14.4 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) Cons_hypoth95 PF03602.15 ETO29521.1 - 0.053 13.2 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Conserved hypothetical protein 95 PRMT5_C PF17286.2 ETO29521.1 - 0.062 13.2 0.3 0.096 12.6 0.3 1.3 1 0 0 1 1 1 0 PRMT5 oligomerisation domain Rhodanese PF00581.20 ETO29523.1 - 8.1e-14 52.0 0.1 1.3e-13 51.3 0.1 1.4 1 0 0 1 1 1 1 Rhodanese-like domain Neuromodulin_N PF10580.9 ETO29523.1 - 0.096 12.5 1.1 0.63 9.9 0.6 2.1 2 0 0 2 2 2 0 Gap junction protein N-terminal region Folate_carrier PF01770.18 ETO29523.1 - 0.11 11.2 0.2 0.15 10.8 0.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier Vpu PF00558.19 ETO29523.1 - 0.11 12.2 1.0 0.14 12.0 0.1 1.7 2 0 0 2 2 2 0 Vpu protein DUF2097 PF09870.9 ETO29524.1 - 0.049 13.8 2.0 3 8.1 0.1 2.5 2 1 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2097) Ion_trans PF00520.31 ETO29525.1 - 1.3e-34 119.6 6.8 1.9e-22 79.7 1.6 2.4 2 0 0 2 2 2 2 Ion transport protein Hid1 PF12722.7 ETO29525.1 - 0.0032 15.7 6.4 0.0058 14.8 6.4 1.3 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein CDC45 PF02724.14 ETO29525.1 - 0.0079 14.6 0.1 0.0079 14.6 0.1 2.2 2 0 0 2 2 2 1 CDC45-like protein Cadherin_C_2 PF16492.5 ETO29525.1 - 0.014 16.1 2.5 0.26 12.1 0.1 3.0 2 1 0 2 2 2 0 Cadherin cytoplasmic C-terminal Connexin PF00029.19 ETO29525.1 - 0.029 14.1 1.5 1.3 8.7 0.5 2.5 2 0 0 2 2 2 0 Connexin DUF2956 PF11169.8 ETO29525.1 - 0.13 12.4 8.9 0.19 12.0 1.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2956) DUF913 PF06025.12 ETO29525.1 - 0.16 10.9 4.8 0.058 12.4 0.7 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) Gpr1_Fun34_YaaH PF01184.19 ETO29525.1 - 0.25 10.9 2.6 22 4.6 2.2 2.4 2 0 0 2 2 2 0 GPR1/FUN34/yaaH family PPL5 PF18168.1 ETO29525.1 - 0.54 9.5 5.5 8.2 5.6 0.1 2.2 2 0 0 2 2 2 0 Prim-pol family 5 Spore_coat_CotO PF14153.6 ETO29525.1 - 1.3 8.9 11.7 0.098 12.6 4.8 2.1 2 0 0 2 2 2 0 Spore coat protein CotO CPSF100_C PF13299.6 ETO29525.1 - 2.4 8.3 9.7 0.59 10.3 1.9 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pex14_N PF04695.13 ETO29525.1 - 3.4 8.3 9.2 0.44 11.2 4.7 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PGA2 PF07543.12 ETO29525.1 - 5.1 7.1 13.8 0.26 11.3 5.7 2.2 2 0 0 2 2 2 0 Protein trafficking PGA2 SLC12 PF03522.15 ETO29525.1 - 5.7 5.8 9.8 7.6 5.4 4.8 2.0 2 0 0 2 2 2 0 Solute carrier family 12 RR_TM4-6 PF06459.12 ETO29525.1 - 6.7 6.4 17.0 2.7 7.8 10.0 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 FAM60A PF15396.6 ETO29525.1 - 9.4 6.2 15.8 7.9 6.4 1.4 2.1 2 0 0 2 2 2 0 Protein Family FAM60A Nop14 PF04147.12 ETO29526.1 - 0.81 7.8 21.2 0.97 7.6 21.2 1.0 1 0 0 1 1 1 0 Nop14-like family Menin PF05053.13 ETO29526.1 - 2.4 6.4 18.2 2.9 6.1 18.2 1.1 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO29526.1 - 6.2 5.5 16.9 7.7 5.2 16.9 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CAC1F_C PF16885.5 ETO29527.1 - 2 8.0 12.5 4.2 6.9 12.2 1.7 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Vps4_C PF09336.10 ETO29528.1 - 3.7e-08 33.2 0.0 8.2e-08 32.1 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ETO29528.1 - 0.00058 19.6 0.0 0.0016 18.2 0.0 1.7 1 1 1 2 2 2 1 AAA+ lid domain DUF2951 PF11166.8 ETO29528.1 - 0.32 11.2 2.8 0.49 10.6 2.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) S_100 PF01023.19 ETO29528.1 - 1.6 8.5 4.7 0.27 11.0 0.6 1.9 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain SART-1 PF03343.13 ETO29529.1 - 0.0016 17.1 0.6 0.0017 17.0 0.6 1.0 1 0 0 1 1 1 1 SART-1 family Cortex-I_coil PF09304.10 ETO29529.1 - 0.23 11.7 5.8 0.24 11.7 0.4 2.0 1 1 1 2 2 2 0 Cortexillin I, coiled coil Snf7 PF03357.21 ETO29529.1 - 0.25 11.0 8.0 0.27 10.8 8.0 1.0 1 0 0 1 1 1 0 Snf7 MJ1316 PF04457.12 ETO29531.1 - 1.3e-08 35.4 0.2 8.8e-08 32.8 0.2 2.4 1 1 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain Myosin_tail_1 PF01576.19 ETO29531.1 - 0.03 12.1 6.2 0.041 11.7 6.2 1.1 1 0 0 1 1 1 0 Myosin tail O-antigen_lig PF13425.6 ETO29531.1 - 0.069 11.9 2.0 0.092 11.5 2.0 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein SAP PF02037.27 ETO29532.1 - 2.9e-05 23.7 1.2 5.4e-05 22.8 1.2 1.5 1 0 0 1 1 1 1 SAP domain MATH PF00917.26 ETO29532.1 - 0.00038 20.6 1.4 0.0012 19.0 1.4 1.9 1 1 0 1 1 1 1 MATH domain BTB PF00651.31 ETO29533.1 - 3.7e-19 69.0 0.8 1.2e-18 67.4 0.2 2.0 2 0 0 2 2 2 1 BTB/POZ domain BACK PF07707.15 ETO29533.1 - 0.0042 17.1 0.4 0.013 15.5 0.1 2.0 2 0 0 2 2 2 1 BTB And C-terminal Kelch WAK PF08488.11 ETO29533.1 - 0.076 13.5 0.2 0.076 13.5 0.2 1.7 2 0 0 2 2 2 0 Wall-associated kinase HEPN-like_int PF18867.1 ETO29533.1 - 0.24 11.3 4.4 0.065 13.1 1.0 1.8 2 0 0 2 2 2 0 HEPN-like integron domain Ribosomal_L18_c PF14204.6 ETO29533.1 - 1.1 10.2 6.8 0.44 11.5 1.6 2.4 2 0 0 2 2 2 0 Ribosomal L18 C-terminal region RRM_1 PF00076.22 ETO29534.1 - 2.1e-32 110.7 0.6 1.1e-18 66.8 0.0 3.3 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO29534.1 - 0.0021 18.2 0.1 1.9 8.6 0.0 2.7 2 1 0 2 2 2 2 RNA recognition motif ICMT PF04140.14 ETO29535.1 - 1.2e-18 67.4 0.1 1.9e-18 66.6 0.1 1.3 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO29535.1 - 9.9e-12 45.2 0.7 1.7e-11 44.4 0.7 1.4 1 0 0 1 1 1 1 Phospholipid methyltransferase ERG4_ERG24 PF01222.17 ETO29535.1 - 9.5e-07 27.9 0.4 9.5e-07 27.9 0.4 1.4 1 1 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF4407 PF14362.6 ETO29536.1 - 0.083 12.2 2.6 0.16 11.3 2.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Polo_box_3 PF18544.1 ETO29538.1 - 0.051 14.2 0.1 0.13 12.9 0.1 1.7 1 0 0 1 1 1 0 Polo box domain BcrAD_BadFG PF01869.20 ETO29539.1 - 0.0012 18.4 0.0 0.002 17.7 0.0 1.3 1 0 0 1 1 1 1 BadF/BadG/BcrA/BcrD ATPase family DUF2300 PF10062.9 ETO29539.1 - 0.065 13.3 0.2 0.11 12.5 0.2 1.3 1 0 0 1 1 1 0 Predicted secreted protein (DUF2300) HSP70 PF00012.20 ETO29539.1 - 0.1 10.7 0.0 0.5 8.5 0.0 1.9 2 0 0 2 2 2 0 Hsp70 protein DDR PF08841.10 ETO29539.1 - 0.21 10.5 0.0 0.32 9.9 0.0 1.2 1 0 0 1 1 1 0 Diol dehydratase reactivase ATPase-like domain Sec20 PF03908.13 ETO29541.1 - 0.045 13.7 0.0 0.064 13.2 0.0 1.2 1 0 0 1 1 1 0 Sec20 Elf1 PF05129.13 ETO29541.1 - 0.058 13.5 0.1 0.12 12.5 0.1 1.5 1 0 0 1 1 1 0 Transcription elongation factor Elf1 like Nab2 PF11517.8 ETO29542.1 - 0.036 14.4 0.0 0.075 13.3 0.0 1.4 1 0 0 1 1 1 0 Nuclear abundant poly(A) RNA-bind protein 2 (Nab2) HSP70 PF00012.20 ETO29543.1 - 0.04 12.1 0.0 0.55 8.3 0.0 2.1 2 0 0 2 2 2 0 Hsp70 protein Hydantoinase_A PF01968.18 ETO29543.1 - 0.21 10.8 0.0 0.5 9.6 0.0 1.5 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase DUF5092 PF17010.5 ETO29545.1 - 0.036 14.0 1.5 0.06 13.3 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF5092) TraC PF07820.12 ETO29545.1 - 0.049 14.0 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 TraC-like protein TMEM154 PF15102.6 ETO29545.1 - 2.6 7.9 5.6 6.5 6.7 2.1 2.5 2 0 0 2 2 2 0 TMEM154 protein family TRAPP PF04051.16 ETO29546.1 - 5.7e-33 113.7 0.0 7.1e-33 113.4 0.0 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component Kelch_4 PF13418.6 ETO29548.1 - 0.00059 19.8 0.1 0.0089 16.0 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29548.1 - 0.052 13.5 0.6 0.34 11.0 0.0 2.6 2 0 0 2 2 2 0 Kelch motif Kelch_5 PF13854.6 ETO29548.1 - 0.12 12.3 1.4 1.3 9.1 0.1 2.6 3 0 0 3 3 3 0 Kelch motif GTP_EFTU PF00009.27 ETO29549.1 - 2.9e-48 164.0 0.0 4.5e-48 163.4 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain EFG_IV PF03764.18 ETO29549.1 - 1.1e-34 118.9 0.0 3.3e-34 117.2 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G, domain IV EFG_II PF14492.6 ETO29549.1 - 7.4e-29 99.7 0.0 1.8e-28 98.4 0.0 1.7 1 0 0 1 1 1 1 Elongation Factor G, domain II EFG_C PF00679.24 ETO29549.1 - 2.9e-21 75.3 0.0 8.4e-21 73.8 0.0 1.9 2 0 0 2 2 2 1 Elongation factor G C-terminus GTP_EFTU_D2 PF03144.25 ETO29549.1 - 5.5e-08 33.1 0.0 2.3e-07 31.1 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 2 RF3_C PF16658.5 ETO29549.1 - 0.00033 20.5 0.0 0.00075 19.3 0.0 1.5 1 0 0 1 1 1 1 Class II release factor RF3, C-terminal domain MMR_HSR1 PF01926.23 ETO29549.1 - 0.011 15.8 0.0 0.023 14.8 0.0 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase AIG1 PF04548.16 ETO29549.1 - 0.019 14.3 0.1 0.034 13.5 0.1 1.3 1 0 0 1 1 1 0 AIG1 family Aa_trans PF01490.18 ETO29550.1 - 1.6e-18 66.6 0.2 2.5e-18 66.0 0.2 1.2 1 0 0 1 1 1 1 Transmembrane amino acid transporter protein CPP1-like PF11833.8 ETO29550.1 - 0.0039 16.9 5.0 0.029 14.0 2.4 2.8 2 1 1 3 3 3 2 Protein CHAPERONE-LIKE PROTEIN OF POR1-like V_ATPase_I PF01496.19 ETO29552.1 - 7.8e-212 705.5 14.0 4.6e-146 487.9 11.5 2.0 1 1 1 2 2 2 2 V-type ATPase 116kDa subunit family DUF4642 PF15484.6 ETO29552.1 - 0.043 14.1 0.1 0.078 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4642) RNase_T PF00929.24 ETO29553.1 - 2.4e-24 86.8 0.4 2.8e-23 83.2 0.4 2.0 1 1 0 1 1 1 1 Exonuclease Peptidase_S64 PF08192.11 ETO29553.1 - 0.028 12.9 0.0 0.033 12.7 0.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 FoP_duplication PF13865.6 ETO29554.1 - 0.0046 17.5 2.0 0.0046 17.5 2.0 3.5 3 0 0 3 3 3 2 C-terminal duplication domain of Friend of PRMT1 WD40 PF00400.32 ETO29555.1 - 1.3e-59 196.7 19.4 6.3e-11 42.7 0.2 7.7 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29555.1 - 7.8e-22 77.4 3.8 0.001 19.3 0.0 6.5 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29555.1 - 4.1e-12 45.7 3.9 0.047 12.6 0.1 5.7 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO29555.1 - 3.2e-08 32.7 4.8 1 7.9 0.0 5.8 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29555.1 - 2.8e-06 26.9 0.4 0.54 9.5 0.1 3.4 3 0 0 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO29555.1 - 8.1e-05 21.3 0.2 0.019 13.5 0.1 3.0 3 0 0 3 3 3 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO29555.1 - 0.0021 17.1 1.3 5.7 5.8 0.0 4.1 2 2 1 4 4 4 2 Partner and localizer of BRCA2 WD40 domain PDDEXK_1 PF12705.7 ETO29555.1 - 0.022 14.7 0.1 34 4.2 0.0 3.2 3 0 0 3 3 3 0 PD-(D/E)XK nuclease superfamily PQQ PF01011.21 ETO29555.1 - 0.068 13.1 0.0 40 4.4 0.0 4.2 5 0 0 5 5 5 0 PQQ enzyme repeat Coilin_N PF15862.5 ETO29556.1 - 0.0058 16.4 4.9 0.0058 16.4 4.9 2.1 2 1 0 2 2 2 1 Coilin N-terminus AAR2 PF05282.11 ETO29556.1 - 0.42 10.0 6.3 0.52 9.7 6.3 1.2 1 0 0 1 1 1 0 AAR2 protein AAA PF00004.29 ETO29557.1 - 2.7e-44 150.8 0.0 3.4e-44 150.5 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO29557.1 - 2.1e-07 31.5 0.0 0.00036 21.0 0.0 2.2 1 1 1 2 2 2 2 AAA ATPase domain RuvB_N PF05496.12 ETO29557.1 - 2.3e-06 27.5 0.0 9.2e-06 25.5 0.0 1.9 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETO29557.1 - 2.7e-05 24.4 0.0 0.0012 19.1 0.0 2.2 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO29557.1 - 7.6e-05 22.7 0.1 0.0012 18.9 0.1 2.6 2 1 0 2 2 2 1 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ETO29557.1 - 0.00073 19.9 0.0 0.0023 18.3 0.0 1.8 2 0 0 2 2 2 1 RNA helicase AAA_2 PF07724.14 ETO29557.1 - 0.0011 19.2 0.0 0.0025 18.0 0.0 1.6 1 1 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_14 PF13173.6 ETO29557.1 - 0.0011 19.0 0.0 0.0015 18.6 0.0 1.3 1 0 0 1 1 1 1 AAA domain TIP49 PF06068.13 ETO29557.1 - 0.0013 18.0 0.0 0.002 17.4 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain IstB_IS21 PF01695.17 ETO29557.1 - 0.0016 18.2 0.0 0.0024 17.7 0.0 1.3 1 0 0 1 1 1 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO29557.1 - 0.002 17.5 0.1 0.0055 16.1 0.0 1.7 2 0 0 2 2 1 1 Magnesium chelatase, subunit ChlI TsaE PF02367.17 ETO29557.1 - 0.011 15.7 0.0 0.016 15.2 0.0 1.2 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ETO29557.1 - 0.012 15.8 0.0 0.014 15.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO29557.1 - 0.012 16.1 0.0 0.017 15.6 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETO29557.1 - 0.015 14.8 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region Sigma54_activat PF00158.26 ETO29557.1 - 0.017 14.8 0.0 0.21 11.3 0.0 2.3 1 1 0 2 2 2 0 Sigma-54 interaction domain AAA_3 PF07726.11 ETO29557.1 - 0.023 14.6 0.0 0.035 14.0 0.0 1.5 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_17 PF13207.6 ETO29557.1 - 0.025 15.0 0.0 0.038 14.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETO29557.1 - 0.03 14.0 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO29557.1 - 0.031 13.7 0.0 0.052 13.0 0.0 1.3 1 0 0 1 1 1 0 PhoH-like protein DUF815 PF05673.13 ETO29557.1 - 0.032 13.4 0.0 0.055 12.6 0.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF815) NACHT PF05729.12 ETO29557.1 - 0.05 13.5 0.5 0.37 10.7 0.0 2.3 3 0 0 3 3 3 0 NACHT domain ABC_tran PF00005.27 ETO29557.1 - 0.059 13.9 0.0 0.084 13.4 0.0 1.5 1 1 0 1 1 1 0 ABC transporter AAA_28 PF13521.6 ETO29557.1 - 0.059 13.6 0.0 0.099 12.9 0.0 1.4 1 1 0 1 1 1 0 AAA domain AAA_11 PF13086.6 ETO29557.1 - 0.064 13.0 0.0 0.089 12.6 0.0 1.1 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ETO29557.1 - 0.1 11.9 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 KaiC Parvo_NS1 PF01057.17 ETO29557.1 - 0.11 11.6 0.0 0.16 11.0 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 AAA_25 PF13481.6 ETO29557.1 - 0.13 11.9 0.0 0.23 11.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Sigma54_activ_2 PF14532.6 ETO29557.1 - 0.13 12.4 0.0 0.33 11.0 0.0 1.7 2 1 0 2 2 1 0 Sigma-54 interaction domain DUF2075 PF09848.9 ETO29557.1 - 0.19 10.9 0.0 0.27 10.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Na_trans_assoc PF06512.13 ETO29558.1 - 0.39 11.0 15.4 0.41 10.9 15.4 1.1 1 0 0 1 1 1 0 Sodium ion transport-associated Sec62 PF03839.16 ETO29558.1 - 1.7 8.1 7.6 1.9 7.9 7.6 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 BSP_II PF05432.11 ETO29558.1 - 6.3 6.4 19.3 7.8 6.1 19.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) SLC12 PF03522.15 ETO29558.1 - 9.5 5.1 8.3 10 5.0 8.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PfkB PF00294.24 ETO29559.1 - 2.8e-45 154.9 0.2 8.8e-45 153.3 0.2 1.7 1 1 0 1 1 1 1 pfkB family carbohydrate kinase SHE3 PF17078.5 ETO29560.1 - 1e-06 28.7 5.5 1e-06 28.7 5.5 2.4 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 Apolipoprotein PF01442.18 ETO29560.1 - 0.023 14.6 4.2 0.066 13.1 4.2 1.8 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain Baculo_PEP_C PF04513.12 ETO29560.1 - 0.18 11.9 0.4 0.42 10.7 0.4 1.6 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3450 PF11932.8 ETO29560.1 - 0.57 9.4 9.3 0.1 11.9 0.6 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) Glyoxalase PF00903.25 ETO29561.1 - 9e-08 32.4 0.0 1.3e-07 31.8 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_4 PF13669.6 ETO29561.1 - 0.0013 19.0 0.0 0.0021 18.3 0.0 1.5 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Rsm1 PF08600.10 ETO29562.1 - 4.6 7.5 6.1 0.61 10.3 0.7 2.4 2 0 0 2 2 2 0 Rsm1-like Acetyltransf_1 PF00583.25 ETO29563.1 - 3.4e-12 46.6 0.0 6e-12 45.8 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO29563.1 - 2.7e-09 37.1 0.1 8.6e-09 35.4 0.1 1.8 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO29563.1 - 1.5e-06 28.5 0.1 2.8e-06 27.7 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETO29563.1 - 0.03 14.4 0.0 0.084 12.9 0.0 1.8 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain LepB_GAP_N PF18172.1 ETO29564.1 - 0.0049 16.8 0.2 0.0056 16.6 0.2 1.1 1 0 0 1 1 1 1 LepB GAP domain N-terminal subdomain PRP1_N PF06424.12 ETO29564.1 - 0.45 10.9 6.1 0.56 10.6 6.1 1.1 1 0 0 1 1 1 0 PRP1 splicing factor, N-terminal O-antigen_lig PF13425.6 ETO29564.1 - 1.6 7.4 4.8 1.9 7.2 4.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein A_deaminase PF00962.22 ETO29565.1 - 1e-49 169.7 0.4 6e-39 134.3 0.1 2.2 2 0 0 2 2 2 2 Adenosine/AMP deaminase A_deaminase PF00962.22 ETO29566.1 - 7.9e-16 58.3 0.0 5.5e-15 55.5 0.0 2.1 1 1 0 1 1 1 1 Adenosine/AMP deaminase Zip PF02535.22 ETO29567.1 - 2.2 7.4 6.6 5.5 6.1 7.0 1.4 2 0 0 2 2 2 0 ZIP Zinc transporter Hydrolase_4 PF12146.8 ETO29568.1 - 5.2e-06 25.9 0.0 5.2e-06 25.9 0.0 1.2 1 0 0 1 1 1 1 Serine aminopeptidase, S33 Abhydrolase_3 PF07859.13 ETO29568.1 - 0.00059 19.7 0.0 0.00072 19.5 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_2 PF02230.16 ETO29568.1 - 0.001 18.9 0.0 0.0011 18.8 0.0 1.1 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Peptidase_S9 PF00326.21 ETO29568.1 - 0.0011 18.4 0.0 0.0013 18.2 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF2974 PF11187.8 ETO29568.1 - 0.0025 17.4 0.0 0.0031 17.1 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) Abhydrolase_5 PF12695.7 ETO29568.1 - 0.0051 16.6 0.0 0.0059 16.4 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family Esterase_phd PF10503.9 ETO29568.1 - 0.0075 15.8 0.0 0.0092 15.5 0.0 1.1 1 0 0 1 1 1 1 Esterase PHB depolymerase Abhydrolase_1 PF00561.20 ETO29568.1 - 0.013 15.1 0.0 0.029 14.0 0.0 1.6 1 1 1 2 2 2 0 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO29568.1 - 0.043 14.4 0.0 0.043 14.4 0.0 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase family AXE1 PF05448.12 ETO29568.1 - 0.049 12.3 0.0 0.059 12.0 0.0 1.1 1 0 0 1 1 1 0 Acetyl xylan esterase (AXE1) DUF3397 PF11877.8 ETO29568.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3397) UPF0227 PF05728.12 ETO29568.1 - 0.16 11.9 0.0 0.18 11.7 0.0 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) Esterase PF00756.20 ETO29568.1 - 0.23 11.1 0.0 0.29 10.8 0.0 1.1 1 0 0 1 1 1 0 Putative esterase Mucin PF01456.17 ETO29569.1 - 0.051 13.6 39.3 0.11 12.4 39.3 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF2157 PF09925.9 ETO29569.1 - 2.8 7.7 6.7 1 9.1 2.6 2.2 1 1 0 2 2 2 0 Predicted membrane protein (DUF2157) Sirohm_synth_C PF14823.6 ETO29570.1 - 0.065 12.9 1.2 0.99 9.1 0.2 2.5 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal PTH2 PF01981.16 ETO29571.1 - 0.099 12.9 0.3 0.15 12.3 0.3 1.2 1 0 0 1 1 1 0 Peptidyl-tRNA hydrolase PTH2 PTR2 PF00854.21 ETO29573.1 - 7.5e-65 219.3 0.0 3.2e-64 217.2 0.0 1.8 1 1 0 1 1 1 1 POT family MFS_1 PF07690.16 ETO29573.1 - 9.3e-09 34.7 17.5 0.00056 18.9 0.0 4.0 3 1 0 3 3 3 3 Major Facilitator Superfamily OATP PF03137.20 ETO29573.1 - 6.4e-05 21.4 0.1 6.4e-05 21.4 0.1 2.5 3 0 0 3 3 3 1 Organic Anion Transporter Polypeptide (OATP) family XRN_N PF03159.18 ETO29575.1 - 1.6e-91 306.1 1.5 2.5e-51 174.4 1.6 2.5 2 1 0 2 2 2 2 XRN 5'-3' exonuclease N-terminus XRN_M PF17846.1 ETO29575.1 - 1.3e-27 96.9 0.9 1.3e-27 96.9 0.9 2.1 2 0 0 2 2 2 1 Xrn1 helical domain Methyltransf_12 PF08242.12 ETO29575.1 - 0.00062 20.5 0.2 0.0023 18.7 0.2 2.0 1 1 0 1 1 1 1 Methyltransferase domain zf-CCHC PF00098.23 ETO29575.1 - 0.0069 16.4 1.2 0.014 15.5 1.2 1.5 1 0 0 1 1 1 1 Zinc knuckle DUF2975 PF11188.8 ETO29575.1 - 0.6 10.0 3.8 4.8 7.1 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2975) XRN_M PF17846.1 ETO29576.1 - 2.5e-73 247.5 7.7 9.6e-51 173.1 0.5 2.0 2 0 0 2 2 2 2 Xrn1 helical domain SR-25 PF10500.9 ETO29577.1 - 2.3 7.8 6.5 4.1 7.0 6.5 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein PTPlike_phytase PF14566.6 ETO29578.1 - 0.01 15.9 1.1 0.021 15.0 1.1 1.4 1 0 0 1 1 1 0 Inositol hexakisphosphate Polysacc_deac_1 PF01522.21 ETO29578.1 - 0.13 12.2 2.5 0.84 9.5 0.7 2.3 2 0 0 2 2 2 0 Polysaccharide deacetylase GTSE1_N PF15259.6 ETO29578.1 - 0.32 11.2 3.4 0.63 10.2 3.4 1.4 1 0 0 1 1 1 0 G-2 and S-phase expressed 1 DUF3271 PF11675.8 ETO29580.1 - 0.019 14.2 1.1 0.027 13.7 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3271) KinB_sensor PF16767.5 ETO29580.1 - 0.13 12.7 2.4 0.17 12.3 1.7 1.5 1 1 0 1 1 1 0 Sensor domain of alginate biosynthesis sensor protein KinB Peptidase_S49_N PF08496.10 ETO29580.1 - 0.3 11.2 2.0 0.43 10.6 2.0 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal UPF0242 PF06785.11 ETO29580.1 - 0.57 10.3 8.2 0.11 12.6 4.1 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Chisel PF15355.6 ETO29581.1 - 0.026 14.8 1.0 0.14 12.4 0.9 2.5 1 1 0 1 1 1 0 Stretch-responsive small skeletal muscle X protein, Chisel TFIIA PF03153.13 ETO29581.1 - 6 6.8 35.6 8.6 6.2 35.6 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Apis_Csd PF11671.8 ETO29581.1 - 7.2 6.6 8.9 1.5 8.8 4.6 2.0 2 0 0 2 2 2 0 Complementary sex determiner protein Sad1_UNC PF07738.13 ETO29582.1 - 3.1e-16 59.6 4.5 2e-10 40.8 0.1 2.7 1 1 1 2 2 2 2 Sad1 / UNC-like C-terminal DUF3923 PF13061.6 ETO29582.1 - 0.038 14.1 1.6 0.084 13.0 1.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3923) DUF2244 PF10003.9 ETO29582.1 - 0.082 12.6 0.1 0.31 10.7 0.0 2.0 1 1 1 2 2 2 0 Integral membrane protein (DUF2244) RskA PF10099.9 ETO29582.1 - 0.099 12.9 0.0 0.16 12.3 0.0 1.3 1 0 0 1 1 1 0 Anti-sigma-K factor rskA MAP17 PF15807.5 ETO29582.1 - 0.22 11.8 0.1 0.22 11.8 0.1 2.5 3 0 0 3 3 3 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4834 PF16118.5 ETO29582.1 - 2.7 9.0 14.9 0.17 12.9 1.3 3.7 4 0 0 4 4 4 0 Domain of unknown function (DUF4834) TPR_2 PF07719.17 ETO29583.1 - 8e-12 44.3 27.9 0.26 11.5 0.1 7.9 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO29583.1 - 3.1e-06 27.0 16.6 0.21 11.9 0.1 7.8 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO29583.1 - 6.5e-06 26.5 0.1 3 8.9 0.0 5.0 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29583.1 - 3e-05 23.6 8.2 0.31 10.7 0.1 4.9 5 0 0 5 5 5 2 TPR repeat TPR_12 PF13424.6 ETO29583.1 - 0.00053 20.2 11.8 0.51 10.7 0.0 5.8 6 1 0 6 6 6 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO29583.1 - 0.00058 20.3 0.1 9.6 6.8 0.0 4.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29583.1 - 0.00085 19.0 30.9 0.11 12.3 0.0 7.5 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO29583.1 - 0.0081 16.8 0.1 6.1 7.6 0.0 3.4 3 1 0 3 3 3 1 Tetratricopeptide repeat Defb50 PF17546.2 ETO29583.1 - 0.043 13.7 0.0 0.093 12.6 0.0 1.4 1 0 0 1 1 1 0 Beta defensin 50 TPR_17 PF13431.6 ETO29583.1 - 0.2 12.1 13.7 0.64 10.5 0.1 5.5 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29583.1 - 0.77 9.7 7.8 14 5.7 0.1 4.6 6 0 0 6 6 6 0 Tetratricopeptide repeat Mit_KHE1 PF10173.9 ETO29584.1 - 1.3 9.1 7.6 11 6.0 1.0 3.1 2 1 0 2 2 2 0 Mitochondrial K+-H+ exchange-related HOOK PF05622.12 ETO29586.1 - 0.0024 16.1 29.3 0.0037 15.5 29.3 1.3 1 0 0 1 1 1 1 HOOK protein FlxA PF14282.6 ETO29586.1 - 0.0063 16.5 17.0 0.0063 16.5 17.0 3.3 1 1 2 3 3 3 1 FlxA-like protein Viral_env_E26 PF11050.8 ETO29586.1 - 0.29 10.5 6.0 0.13 11.7 3.1 1.7 1 1 1 2 2 2 0 Virus envelope protein E26 Fib_alpha PF08702.10 ETO29586.1 - 1.2 9.3 28.8 0.24 11.6 20.5 2.2 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family ERM PF00769.19 ETO29586.1 - 3.5 7.4 34.3 6.5 6.5 33.7 1.6 1 1 0 1 1 1 0 Ezrin/radixin/moesin family Spc29 PF17082.5 ETO29586.1 - 4.6 7.0 20.4 13 5.6 20.0 1.8 1 1 0 1 1 1 0 Spindle Pole Component 29 HrpB7 PF09486.10 ETO29586.1 - 6.7 7.1 22.7 1.1e+03 -0.1 20.5 2.6 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF948 PF06103.11 ETO29586.1 - 6.8 7.0 14.4 2.8 8.3 3.8 3.3 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF948) YtxH PF12732.7 ETO29586.1 - 7.5 7.2 10.7 2.6e+03 -1.0 10.7 2.8 1 1 0 1 1 1 0 YtxH-like protein Voltage_CLC PF00654.20 ETO29587.1 - 2.1e-19 70.0 9.0 3.9e-19 69.1 8.9 1.6 1 1 0 1 1 1 1 Voltage gated chloride channel Big_5 PF13205.6 ETO29588.1 - 0.0034 18.1 0.0 0.0053 17.4 0.0 1.3 1 0 0 1 1 1 1 Bacterial Ig-like domain CDC45 PF02724.14 ETO29589.1 - 0.71 8.1 28.5 0.47 8.7 18.2 2.1 2 0 0 2 2 2 0 CDC45-like protein BSP_II PF05432.11 ETO29589.1 - 0.81 9.3 39.8 1.2 8.7 22.9 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 ETO29589.1 - 3.6 6.9 27.2 0.43 9.9 17.7 2.1 2 0 0 2 2 2 0 SDA1 YL1 PF05764.13 ETO29590.1 - 0.001 19.2 14.6 0.0012 19.1 14.6 1.1 1 0 0 1 1 1 1 YL1 nuclear protein TFIIF_alpha PF05793.12 ETO29590.1 - 0.6 8.6 19.1 0.62 8.6 19.1 1.0 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CAC1F_C PF16885.5 ETO29590.1 - 3.6 7.2 13.0 4.8 6.7 13.0 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term CDC45 PF02724.14 ETO29590.1 - 3.9 5.7 17.5 4.5 5.4 17.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Sigma70_ner PF04546.13 ETO29590.1 - 4.5 7.1 14.1 7.5 6.4 14.1 1.4 1 0 0 1 1 1 0 Sigma-70, non-essential region PI3K_1B_p101 PF10486.9 ETO29590.1 - 4.5 4.9 11.6 5 4.8 11.6 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Pox_RNA_Pol_19 PF05320.12 ETO29590.1 - 5.4 7.0 11.0 9 6.2 11.0 1.4 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit Mito_carr PF00153.27 ETO29591.1 - 3.2e-36 123.1 2.1 2.2e-12 46.7 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DnaJ-X PF14308.6 ETO29592.1 - 0.025 14.0 0.1 0.03 13.8 0.1 1.1 1 0 0 1 1 1 0 X-domain of DnaJ-containing SPX PF03105.19 ETO29593.1 - 1.5 8.6 20.9 30 4.4 20.9 2.1 1 1 0 1 1 1 0 SPX domain CSG2 PF16965.5 ETO29593.1 - 3 6.7 9.6 3.5 6.5 0.3 3.0 3 0 0 3 3 3 0 Ceramide synthase regulator Secretin_N_2 PF07655.13 ETO29593.1 - 4 8.0 67.4 1.2 9.8 13.5 4.2 4 0 0 4 4 4 0 Secretin N-terminal domain TMEM234 PF10639.9 ETO29594.1 - 8.2e-29 100.0 6.1 1.8e-28 98.9 6.1 1.6 1 0 0 1 1 1 1 Putative transmembrane family 234 EamA PF00892.20 ETO29594.1 - 0.16 12.1 13.1 0.026 14.7 8.4 2.0 2 1 0 2 2 2 0 EamA-like transporter family STT3 PF02516.14 ETO29595.1 - 1.1e-46 159.8 36.9 9.4e-44 150.1 34.2 2.2 2 0 0 2 2 2 2 Oligosaccharyl transferase STT3 subunit DUF3791 PF12668.7 ETO29595.1 - 0.054 13.6 0.1 0.28 11.3 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3791) YL1 PF05764.13 ETO29596.1 - 0.0028 17.8 27.0 0.0028 17.8 27.0 2.2 2 0 0 2 2 2 2 YL1 nuclear protein UPF0492 PF15744.5 ETO29597.1 - 0.086 12.1 8.8 0.09 12.0 8.8 1.0 1 0 0 1 1 1 0 Uncharacterized protein family UPF0492 DUF2201_N PF13203.6 ETO29597.1 - 0.21 11.1 6.6 0.23 11.0 6.6 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain Menin PF05053.13 ETO29597.1 - 1.2 7.4 6.6 1.4 7.2 6.6 1.0 1 0 0 1 1 1 0 Menin CFIA_Pcf11 PF11526.8 ETO29597.1 - 2.1 8.9 10.2 10 6.7 10.2 2.0 1 1 0 1 1 1 0 Subunit of cleavage factor IA Pcf11 Bud13 PF09736.9 ETO29597.1 - 2.9 8.3 15.3 3.7 8.0 15.3 1.1 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex GAGA_bind PF06217.12 ETO29597.1 - 3.2 7.9 11.5 4.2 7.6 11.5 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family Sec62 PF03839.16 ETO29597.1 - 3.4 7.1 10.7 3.7 7.0 10.7 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 NPR3 PF03666.13 ETO29597.1 - 4.4 6.0 11.0 4.9 5.8 11.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PP2C PF00481.21 ETO29600.1 - 0.071 12.7 0.1 0.13 11.9 0.1 1.6 1 1 0 1 1 1 0 Protein phosphatase 2C MtrB PF05440.12 ETO29601.1 - 0.041 14.3 2.6 3 8.3 0.1 3.2 4 1 0 4 4 4 0 Tetrahydromethanopterin S-methyltransferase subunit B Erp_C PF06780.11 ETO29601.1 - 0.18 11.8 2.7 0.59 10.1 2.7 1.9 1 0 0 1 1 1 0 Erp protein C-terminus Prefoldin PF02996.17 ETO29601.1 - 0.38 10.7 16.9 0.068 13.1 0.9 3.7 3 1 1 4 4 4 0 Prefoldin subunit DUF4988 PF16378.5 ETO29601.1 - 1.6 8.4 6.8 0.48 10.1 0.6 2.7 2 1 0 3 3 3 0 Domain of unknown function DASH_Dam1 PF08653.10 ETO29601.1 - 4.9 7.0 5.5 28 4.6 0.1 3.8 4 0 0 4 4 4 0 DASH complex subunit Dam1 ABC_tran PF00005.27 ETO29602.1 - 1.1e-11 45.4 0.0 1.9e-11 44.6 0.0 1.4 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO29602.1 - 6.7e-06 25.7 0.2 8.2e-06 25.4 0.2 1.1 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO29602.1 - 0.033 14.4 1.0 0.72 10.1 1.0 2.3 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit ABC_tran PF00005.27 ETO29603.1 - 9.3e-15 55.3 0.0 4.7e-14 53.1 0.0 2.1 1 1 0 1 1 1 1 ABC transporter AAA_7 PF12775.7 ETO29603.1 - 0.00023 20.7 0.0 0.0017 17.9 0.0 2.0 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_16 PF13191.6 ETO29603.1 - 0.00044 20.7 0.0 0.00079 19.8 0.0 1.5 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO29603.1 - 0.0066 16.4 0.0 0.012 15.5 0.0 1.4 1 1 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ETO29603.1 - 0.0077 16.0 0.0 0.014 15.1 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain ABC_membrane PF00664.23 ETO29603.1 - 0.015 15.0 5.4 0.024 14.3 5.4 1.4 1 0 0 1 1 1 0 ABC transporter transmembrane region AAA_22 PF13401.6 ETO29603.1 - 0.037 14.3 0.0 0.061 13.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain Macoilin PF09726.9 ETO29603.1 - 0.05 12.2 0.0 0.071 11.7 0.0 1.1 1 0 0 1 1 1 0 Macoilin family RhoGAP PF00620.27 ETO29604.1 - 6.2e-09 35.9 0.0 1.1e-08 35.1 0.0 1.3 1 0 0 1 1 1 1 RhoGAP domain Ribosomal_S25 PF03297.15 ETO29604.1 - 0.035 14.3 6.8 0.066 13.4 6.8 1.4 1 0 0 1 1 1 0 S25 ribosomal protein AA_permease_2 PF13520.6 ETO29605.1 - 8.5e-47 159.9 40.2 1.1e-46 159.6 40.2 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease PF00324.21 ETO29605.1 - 1.2e-31 109.8 36.8 1.5e-31 109.6 36.8 1.1 1 0 0 1 1 1 1 Amino acid permease DUF3087 PF11286.8 ETO29605.1 - 0.081 12.4 0.3 0.081 12.4 0.3 2.1 2 1 0 2 2 2 0 Protein of unknown function (DUF3087) F-box-like PF12937.7 ETO29608.1 - 7e-06 25.8 0.3 2.7e-05 24.0 0.3 2.1 1 0 0 1 1 1 1 F-box-like Sigma_reg_N PF13800.6 ETO29608.1 - 0.048 13.9 0.1 0.16 12.2 0.1 2.0 1 0 0 1 1 1 0 Sigma factor regulator N-terminal F-box PF00646.33 ETO29608.1 - 0.064 13.1 0.3 0.2 11.6 0.3 1.8 1 0 0 1 1 1 0 F-box domain Vesiculo_matrix PF06326.12 ETO29609.1 - 0.056 13.2 0.4 0.085 12.6 0.4 1.3 1 0 0 1 1 1 0 Vesiculovirus matrix protein EF-hand_7 PF13499.6 ETO29610.1 - 1.8e-05 25.1 4.5 0.043 14.3 0.4 2.7 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO29610.1 - 0.00012 21.8 0.8 0.082 12.9 0.1 3.9 3 0 0 3 3 3 1 EF-hand domain EF-hand_8 PF13833.6 ETO29610.1 - 0.0019 18.0 0.7 2.3 8.1 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO29610.1 - 0.003 17.0 4.3 0.47 10.1 0.1 4.5 5 0 0 5 5 5 1 EF hand PRP9_N PF16958.5 ETO29610.1 - 2.6 8.1 7.4 1.1 9.2 0.4 2.8 2 1 0 3 3 3 0 Pre-mRNA-splicing factor PRP9 N-terminus ETRAMP PF09716.10 ETO29611.1 - 0.038 14.0 0.0 1.5 8.9 0.0 3.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) PC_rep PF01851.22 ETO29611.1 - 0.11 13.0 0.3 1 9.9 0.0 3.0 2 0 0 2 2 2 0 Proteasome/cyclosome repeat Kelch_1 PF01344.25 ETO29612.1 - 9.1e-09 34.8 1.4 0.00033 20.2 0.6 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO29612.1 - 1e-07 31.6 3.6 0.0014 18.5 0.6 4.6 4 1 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO29612.1 - 2.5e-07 30.8 1.4 0.02 15.2 0.2 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO29612.1 - 4.7e-07 29.9 0.0 3.6e-05 23.9 0.0 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO29612.1 - 2.3e-05 24.3 0.4 0.011 15.8 0.2 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO29612.1 - 5.9e-05 23.0 2.3 0.23 11.5 0.9 4.0 4 0 0 4 4 4 1 Kelch motif N_Asn_amidohyd PF14736.6 ETO29612.1 - 0.086 12.0 0.1 4.4 6.4 0.0 2.3 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Aldedh PF00171.22 ETO29615.1 - 2.8e-77 260.2 0.0 3.1e-77 260.0 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family YL1 PF05764.13 ETO29617.1 - 0.24 11.5 12.4 0.34 11.0 1.6 2.3 2 0 0 2 2 2 0 YL1 nuclear protein DUF1394 PF07159.12 ETO29618.1 - 4.6e-27 95.1 0.4 5.6e-27 94.8 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Neur_chan_memb PF02932.16 ETO29620.1 - 2.6 8.0 6.0 3.3 7.7 6.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO29623.1 - 0.018 13.9 4.2 0.024 13.4 4.2 1.2 1 0 0 1 1 1 0 Presenilin SPX PF03105.19 ETO29623.1 - 0.07 13.0 16.8 0.092 12.7 16.8 1.1 1 0 0 1 1 1 0 SPX domain Lin-8 PF03353.15 ETO29623.1 - 0.084 12.4 1.8 0.12 11.9 1.6 1.4 1 1 0 1 1 1 0 Ras-mediated vulval-induction antagonist Neur_chan_memb PF02932.16 ETO29623.1 - 0.17 11.9 4.9 0.26 11.3 4.9 1.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SOG2 PF10428.9 ETO29623.1 - 0.23 10.6 16.5 0.31 10.2 16.5 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein NPR3 PF03666.13 ETO29623.1 - 0.44 9.3 8.6 0.39 9.5 2.1 2.0 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 Folate_carrier PF01770.18 ETO29623.1 - 0.66 8.7 3.2 4.3 6.0 0.2 2.0 2 0 0 2 2 2 0 Reduced folate carrier CSG2 PF16965.5 ETO29623.1 - 1 8.3 4.2 2 7.3 0.4 2.0 2 0 0 2 2 2 0 Ceramide synthase regulator Zip PF02535.22 ETO29623.1 - 1.8 7.7 7.8 0.55 9.4 0.7 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Nab6_mRNP_bdg PF10567.9 ETO29623.1 - 2.3 7.6 17.7 2 7.9 8.7 2.1 2 0 0 2 2 2 0 RNA-recognition motif DUF515 PF04415.12 ETO29623.1 - 4 5.7 22.2 5.7 5.2 22.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF4614 PF15391.6 ETO29623.1 - 8.3 6.4 15.5 2.4 8.1 10.6 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4614) Striatin PF08232.12 ETO29623.1 - 8.4 7.0 8.7 8.3 7.0 2.1 2.1 2 0 0 2 2 2 0 Striatin family WD40 PF00400.32 ETO29625.1 - 8.5e-11 42.2 4.7 7e-05 23.5 0.0 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat PD40 PF07676.12 ETO29625.1 - 0.18 11.8 1.2 0.88 9.6 0.0 2.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO29626.1 - 4.7e-13 49.4 2.2 0.0015 19.3 0.0 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat WD40_like PF17005.5 ETO29626.1 - 0.0092 15.3 0.0 0.017 14.4 0.0 1.4 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETO29626.1 - 0.029 13.4 0.0 0.21 10.5 0.0 2.2 1 1 2 3 3 3 0 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO29626.1 - 0.11 12.5 0.4 28 4.8 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO29627.1 - 1.3e-68 225.3 14.9 8.4e-10 39.1 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29627.1 - 2.3e-24 85.5 1.7 0.0025 18.1 0.0 6.4 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29627.1 - 2.2e-14 53.2 0.0 0.074 12.0 0.0 6.1 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29627.1 - 4.6e-12 45.9 0.1 0.0049 16.2 0.0 4.6 3 1 2 5 5 5 4 WD40-like domain eIF2A PF08662.11 ETO29627.1 - 7.9e-10 38.9 0.1 0.00017 21.5 0.0 3.4 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO29627.1 - 1.1e-07 30.9 5.2 0.55 8.8 0.0 5.9 2 1 4 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO29627.1 - 1.4e-06 27.1 1.0 0.0051 15.4 0.1 3.6 2 1 2 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO29627.1 - 2.7e-05 24.0 9.6 3.8 7.6 0.1 6.5 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO29627.1 - 0.0034 16.2 0.6 1.2 7.9 0.0 3.8 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Coatomer_WDAD PF04053.14 ETO29627.1 - 0.0038 16.3 0.2 0.026 13.6 0.1 2.0 1 1 1 2 2 2 2 Coatomer WD associated region NodS PF05401.11 ETO29627.1 - 0.014 15.0 0.6 1.5 8.4 0.0 3.6 4 1 1 5 5 5 0 Nodulation protein S (NodS) PALB2_WD40 PF16756.5 ETO29627.1 - 0.028 13.3 3.8 6.1 5.7 0.1 4.4 1 1 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain SBD PF17882.1 ETO29627.1 - 0.036 13.9 0.1 1.4 8.8 0.0 3.0 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain Plk4_PB1 PF18190.1 ETO29627.1 - 0.053 13.7 1.0 0.91 9.7 0.0 3.3 3 2 1 4 4 4 0 Polo-like Kinase 4 Polo Box 1 RNase_E_G PF10150.9 ETO29628.1 - 0.0013 18.2 2.7 0.0015 18.0 2.7 1.1 1 0 0 1 1 1 1 Ribonuclease E/G family LAGLIDADG_3 PF14528.6 ETO29628.1 - 0.042 14.2 0.3 0.071 13.4 0.3 1.5 1 0 0 1 1 1 0 LAGLIDADG-like domain YgbB PF02542.16 ETO29628.1 - 0.044 14.1 2.8 0.064 13.5 2.8 1.3 1 0 0 1 1 1 0 YgbB family BPL_N PF09825.9 ETO29628.1 - 0.19 10.7 2.9 0.24 10.5 2.9 1.0 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal E1-E2_ATPase PF00122.20 ETO29629.1 - 3.6e-46 156.9 8.6 3.6e-46 156.9 8.6 3.2 3 1 0 3 3 3 1 E1-E2 ATPase Hydrolase PF00702.26 ETO29629.1 - 4.5e-28 99.0 0.0 1.2e-27 97.6 0.0 1.8 2 0 0 2 2 2 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETO29629.1 - 0.013 15.3 3.4 0.049 13.4 0.0 2.6 2 0 0 2 2 2 0 haloacid dehalogenase-like hydrolase SelK_SelG PF10961.8 ETO29629.1 - 0.59 10.8 3.4 18 6.0 0.2 3.3 3 0 0 3 3 3 0 Selenoprotein SelK_SelG CrgA PF06781.12 ETO29629.1 - 2.8 8.1 8.5 8 6.6 0.1 3.7 3 0 0 3 3 3 0 Cell division protein CrgA TMEM208_SND2 PF05620.11 ETO29629.1 - 2.9 7.7 10.8 2.5 7.8 5.1 3.5 2 2 0 2 2 2 0 SRP-independent targeting protein 2/TMEM208 DUF4396 PF14342.6 ETO29629.1 - 8.8 6.7 10.1 0.11 12.9 1.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4396) Rootletin PF15035.6 ETO29630.1 - 0.00012 22.2 24.6 0.00012 22.2 24.6 5.8 2 2 1 4 4 4 1 Ciliary rootlet component, centrosome cohesion CENP-Q PF13094.6 ETO29630.1 - 0.00017 21.8 11.3 0.00017 21.8 11.3 6.5 3 1 3 6 6 6 1 CENP-Q, a CENPA-CAD centromere complex subunit KASH_CCD PF14662.6 ETO29630.1 - 0.0012 18.7 94.2 0.66 9.8 8.9 6.1 2 1 3 6 6 6 5 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 ETO29630.1 - 0.38 10.8 57.2 0.12 12.4 8.6 7.4 5 2 2 7 7 7 0 Protein of unknown function (DUF1664) GAS PF13851.6 ETO29630.1 - 0.56 9.5 99.7 0.086 12.2 18.4 6.4 2 2 3 6 6 6 0 Growth-arrest specific micro-tubule binding YabA PF06156.13 ETO29630.1 - 0.77 10.4 81.8 0.065 13.9 3.4 8.1 3 1 5 8 8 8 0 Initiation control protein YabA APG6_N PF17675.1 ETO29630.1 - 9.8 6.7 96.6 0.2 12.2 22.6 6.7 2 1 4 6 6 6 0 Apg6 coiled-coil region NLE PF08154.12 ETO29631.1 - 2e-13 50.6 0.8 3.4e-13 49.9 0.8 1.4 1 0 0 1 1 1 1 NLE (NUC135) domain UQ_con PF00179.26 ETO29632.1 - 1e-23 83.6 0.1 2.6e-14 53.1 0.1 3.0 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Mucin PF01456.17 ETO29632.1 - 0.0013 18.7 6.2 0.0013 18.7 6.2 2.0 2 0 0 2 2 2 1 Mucin-like glycoprotein ABC_tran_CTD PF16326.5 ETO29633.1 - 0.022 15.0 5.1 0.022 15.0 5.1 5.5 5 0 0 5 5 5 0 ABC transporter C-terminal domain CCDC53 PF10152.9 ETO29634.1 - 0.0022 18.4 13.9 0.0068 16.8 13.9 1.8 1 1 0 1 1 1 1 Subunit CCDC53 of WASH complex TMEM192 PF14802.6 ETO29634.1 - 0.009 15.1 0.2 0.016 14.3 0.2 1.4 1 0 0 1 1 1 1 TMEM192 family SlyX PF04102.12 ETO29634.1 - 0.083 13.5 1.8 0.17 12.5 1.8 1.5 1 0 0 1 1 1 0 SlyX Ashwin PF15323.6 ETO29634.1 - 0.14 12.1 15.5 0.18 11.8 15.5 1.1 1 0 0 1 1 1 0 Developmental protein DUF3402 PF11882.8 ETO29634.1 - 0.54 9.3 11.0 0.74 8.8 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3402) Presenilin PF01080.17 ETO29634.1 - 0.62 8.8 13.9 0.83 8.4 13.9 1.1 1 0 0 1 1 1 0 Presenilin EIIBC-GUT_N PF03612.14 ETO29634.1 - 0.93 9.2 11.6 0.047 13.4 4.5 2.0 1 1 1 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus Menin PF05053.13 ETO29634.1 - 2.3 6.5 22.2 2.8 6.2 22.2 1.0 1 0 0 1 1 1 0 Menin Siah-Interact_N PF09032.11 ETO29634.1 - 2.4 8.5 8.4 0.1 12.9 1.2 2.3 2 1 0 2 2 2 0 Siah interacting protein, N terminal O-antigen_lig PF13425.6 ETO29634.1 - 5.3 5.7 6.0 7.3 5.3 6.0 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein FAM117 PF15388.6 ETO29634.1 - 7.8 5.8 9.5 0.36 10.2 1.1 2.0 1 1 1 2 2 2 0 Protein Family FAM117 Apc15p PF05841.11 ETO29634.1 - 9.6 7.0 22.4 2.9 8.7 14.4 2.2 2 0 0 2 2 2 0 Apc15p protein NCA2 PF08637.10 ETO29636.1 - 6.5e-06 25.5 0.1 7.4e-06 25.3 0.1 1.0 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 Ser_hydrolase PF06821.13 ETO29636.1 - 0.063 13.1 0.4 0.095 12.5 0.1 1.5 1 1 0 1 1 1 0 Serine hydrolase MRAP PF15183.6 ETO29636.1 - 0.082 12.9 0.1 0.17 11.9 0.1 1.6 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Tubulin PF00091.25 ETO29637.1 - 3.4e-16 60.0 0.4 1.5e-15 57.9 0.0 2.0 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO29637.1 - 1.1e-06 28.8 0.5 2.9e-06 27.5 0.5 1.7 1 0 0 1 1 1 1 Tubulin C-terminal domain DUF1462 PF07315.11 ETO29637.1 - 0.0098 16.1 2.0 0.071 13.4 0.1 3.2 4 1 1 5 5 5 1 Protein of unknown function (DUF1462) CNOT1_CAF1_bind PF16415.5 ETO29637.1 - 0.029 13.7 4.7 0.28 10.5 0.2 2.7 2 1 1 3 3 3 0 CCR4-NOT transcription complex subunit 1 CAF1-binding domain Ank_2 PF12796.7 ETO29639.1 - 1.5e-09 38.3 0.1 4.5e-09 36.8 0.1 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO29639.1 - 2e-07 31.2 0.1 4.6e-05 23.6 0.1 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO29639.1 - 2.2e-07 31.3 0.2 1.3e-06 28.8 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO29639.1 - 1.2e-05 25.3 0.5 0.16 12.6 0.0 3.6 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ETO29639.1 - 0.0037 17.6 0.1 0.9 10.1 0.0 2.8 2 0 0 2 2 2 1 Ankyrin repeat PUL PF08324.11 ETO29639.1 - 0.023 13.9 1.8 0.043 13.1 0.3 2.1 2 0 0 2 2 2 0 PUL domain DUF3447 PF11929.8 ETO29639.1 - 0.033 14.1 1.5 1.6 8.7 0.0 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF3447) Arm PF00514.23 ETO29639.1 - 0.045 13.8 11.7 0.54 10.4 0.3 4.8 5 0 0 5 5 5 0 Armadillo/beta-catenin-like repeat zf-TRAF PF02176.18 ETO29640.1 - 1.6e-05 25.5 6.1 1.6e-05 25.5 6.1 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger KASH_CCD PF14662.6 ETO29642.1 - 0.002 18.0 4.9 0.002 18.0 4.9 3.1 3 0 0 3 3 3 1 Coiled-coil region of CCDC155 or KASH UPF0449 PF15136.6 ETO29642.1 - 0.01 16.3 0.2 0.01 16.3 0.2 3.4 3 0 0 3 3 3 0 Uncharacterised protein family UPF0449 Sec16_C PF12931.7 ETO29642.1 - 0.014 15.0 2.1 0.027 14.1 2.1 1.4 1 0 0 1 1 1 0 Sec23-binding domain of Sec16 PRKG1_interact PF15898.5 ETO29642.1 - 0.018 15.9 20.4 0.071 14.0 4.3 4.1 4 0 0 4 4 4 0 cGMP-dependent protein kinase interacting domain HisKA PF00512.25 ETO29642.1 - 0.13 12.3 2.6 0.17 11.9 0.5 2.3 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain DUF4200 PF13863.6 ETO29642.1 - 0.21 12.0 24.5 3.6 8.0 3.8 4.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4200) ABC_tran_CTD PF16326.5 ETO29642.1 - 0.25 11.6 16.3 0.82 10.0 0.2 3.6 3 1 0 3 3 3 0 ABC transporter C-terminal domain betaPIX_CC PF16523.5 ETO29642.1 - 0.26 11.2 10.1 0.09 12.6 0.8 3.2 2 1 0 3 3 3 0 betaPIX coiled coil ArAE_2_N PF10337.9 ETO29642.1 - 0.33 9.9 4.1 0.72 8.8 4.1 1.5 1 1 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal MAS20 PF02064.15 ETO29642.1 - 0.36 10.9 7.5 14 5.8 4.8 2.6 2 0 0 2 2 2 0 MAS20 protein import receptor FliD_C PF07195.12 ETO29642.1 - 0.48 9.8 8.3 1.2 8.5 0.1 2.7 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 C-terminus DivIC PF04977.15 ETO29642.1 - 0.51 10.1 19.0 0.51 10.1 2.3 4.1 4 0 0 4 4 4 0 Septum formation initiator Syntaxin-6_N PF09177.11 ETO29642.1 - 0.58 10.7 13.6 6.5 7.4 6.9 3.3 2 1 0 2 2 2 0 Syntaxin 6, N-terminal MerR-DNA-bind PF09278.11 ETO29642.1 - 0.81 10.3 9.7 7.7 7.1 0.7 3.4 3 0 0 3 3 3 0 MerR, DNA binding DUF948 PF06103.11 ETO29642.1 - 0.86 9.9 2.3 41 4.5 0.1 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF4446 PF14584.6 ETO29642.1 - 0.97 9.4 12.6 0.37 10.8 1.6 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4446) Prefoldin PF02996.17 ETO29642.1 - 1.1 9.1 9.7 1.5 8.7 0.2 3.4 3 0 0 3 3 3 0 Prefoldin subunit Jnk-SapK_ap_N PF09744.9 ETO29642.1 - 1.4 9.1 23.7 1.1 9.5 4.9 3.3 3 0 0 3 3 3 0 JNK_SAPK-associated protein-1 Fmp27_SW PF10305.9 ETO29642.1 - 4 8.2 7.7 6.4 7.6 2.2 2.6 2 0 0 2 2 2 0 RNA pol II promoter Fmp27 protein domain DUF1664 PF07889.12 ETO29642.1 - 8.9 6.4 11.9 2.9 7.9 0.6 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1664) GIT_CC PF16559.5 ETO29643.1 - 0.00049 19.9 1.0 0.0011 18.8 1.0 1.5 1 0 0 1 1 1 1 GIT coiled-coil Rho guanine nucleotide exchange factor SseC PF04888.12 ETO29643.1 - 0.019 14.6 0.1 0.026 14.1 0.1 1.2 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family WD40 PF00400.32 ETO29644.1 - 5.6e-36 121.9 14.4 1.5e-07 32.0 0.0 8.1 9 0 0 9 9 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29644.1 - 3.5e-17 62.5 0.5 0.18 12.1 0.0 7.7 2 1 6 8 8 8 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO29644.1 - 1.9e-10 40.9 0.2 0.0014 18.6 0.0 4.7 1 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO29644.1 - 4.4e-09 35.7 1.2 0.14 11.1 0.0 5.6 1 1 6 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO29644.1 - 1e-06 28.5 3.1 5.8 7.0 0.0 5.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_5 PF13854.6 ETO29644.1 - 1.9e-06 27.7 0.5 0.016 15.2 0.2 4.1 4 0 0 4 4 4 1 Kelch motif Cytochrom_D1 PF02239.16 ETO29644.1 - 0.0017 17.0 0.6 0.31 9.5 0.1 2.4 1 1 2 3 3 3 2 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO29644.1 - 0.014 15.3 0.6 2.2 8.4 0.1 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO29644.1 - 0.017 15.1 0.0 0.061 13.3 0.0 2.0 1 0 0 1 1 1 0 Galactose oxidase, central domain Nup160 PF11715.8 ETO29644.1 - 0.049 12.3 0.0 5.6 5.5 0.0 2.7 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO29644.1 - 0.057 13.7 2.8 7 7.1 0.2 3.4 3 0 0 3 3 3 0 Kelch motif Nucleoporin_N PF08801.11 ETO29644.1 - 0.062 12.0 0.8 8.8 4.9 0.1 2.8 1 1 2 3 3 3 0 Nup133 N terminal like Kelch_1 PF01344.25 ETO29644.1 - 0.13 11.9 1.0 17 5.1 0.2 2.9 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO29645.1 - 1.5e-92 300.9 56.4 7.7e-09 36.1 0.9 16.0 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29645.1 - 7.4e-19 67.8 18.7 0.23 11.8 0.1 11.8 2 1 11 13 13 13 7 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO29645.1 - 9.4e-10 38.6 0.0 1.8e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Ge1_WD40 PF16529.5 ETO29645.1 - 1e-08 34.5 6.6 0.81 8.6 0.0 8.8 3 2 4 8 8 8 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO29645.1 - 2.3e-06 27.1 3.7 6.1e-06 25.8 3.2 2.0 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) AAA_22 PF13401.6 ETO29645.1 - 5.4e-05 23.5 0.1 0.00031 21.0 0.1 2.4 1 1 0 1 1 1 1 AAA domain SGL PF08450.12 ETO29645.1 - 0.00078 19.1 0.1 0.21 11.1 0.1 3.3 3 1 0 4 4 4 1 SMP-30/Gluconolactonase/LRE-like region Str_synth PF03088.16 ETO29645.1 - 0.0023 18.0 0.7 7.4 6.8 0.0 5.7 6 1 1 7 7 7 1 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO29645.1 - 0.003 17.7 0.1 0.011 15.9 0.1 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO29645.1 - 0.0043 17.6 0.0 0.022 15.3 0.0 2.4 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO29645.1 - 0.0078 16.6 0.1 0.13 12.7 0.0 3.2 2 0 0 2 2 2 1 RNA helicase AAA_16 PF13191.6 ETO29645.1 - 0.013 15.9 0.0 0.054 13.9 0.0 2.0 1 1 0 1 1 1 0 AAA ATPase domain DUF5570 PF17731.1 ETO29645.1 - 0.023 14.8 9.3 9.2 6.4 0.1 6.6 4 2 3 7 7 6 0 Family of unknown function (DUF5570) ABC_tran PF00005.27 ETO29645.1 - 0.031 14.8 0.8 0.25 11.8 0.0 3.0 3 0 0 3 3 3 0 ABC transporter PD40 PF07676.12 ETO29645.1 - 0.036 14.0 7.6 53 3.9 0.0 6.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat AAA_5 PF07728.14 ETO29645.1 - 0.036 14.0 0.0 0.28 11.2 0.0 2.3 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TsaE PF02367.17 ETO29645.1 - 0.093 12.7 0.0 0.43 10.6 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE WD40 PF00400.32 ETO29646.1 - 2.7e-59 195.7 19.3 1.1e-09 38.7 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29646.1 - 4.7e-19 68.5 4.4 0.011 16.0 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29646.1 - 9.9e-13 48.1 0.5 0.00076 18.9 0.1 3.4 3 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO29646.1 - 4.1e-09 35.6 3.5 0.22 10.1 0.0 5.3 1 1 5 6 6 6 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO29646.1 - 1.7e-06 27.2 1.2 0.46 9.4 0.2 4.9 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF4265 PF14085.6 ETO29646.1 - 0.042 13.8 0.2 3.5 7.6 0.1 3.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4265) Esterase_phd PF10503.9 ETO29646.1 - 0.11 12.0 0.0 0.18 11.3 0.0 1.2 1 0 0 1 1 1 0 Esterase PHB depolymerase nos_propeller PF18764.1 ETO29646.1 - 0.12 12.3 0.0 7.8 6.5 0.0 3.0 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat PD40 PF07676.12 ETO29646.1 - 0.17 11.9 3.3 14 5.7 0.1 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO29646.1 - 0.19 10.6 5.0 0.96 8.3 0.1 3.8 1 1 3 4 4 4 0 Partner and localizer of BRCA2 WD40 domain MFS_1 PF07690.16 ETO29647.1 - 8e-07 28.3 0.0 8.8e-07 28.2 0.0 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily DIOX_N PF14226.6 ETO29648.1 - 1.2e-21 77.7 0.4 5.1e-21 75.6 0.4 2.0 1 1 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETO29648.1 - 1.6e-15 57.4 0.1 2.9e-15 56.6 0.1 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ank_2 PF12796.7 ETO29649.1 - 2.8e-30 104.8 0.0 1.8e-08 34.9 0.0 3.4 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO29649.1 - 6.4e-27 93.6 0.0 1.8e-08 34.8 0.0 5.2 3 1 2 5 5 5 5 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO29649.1 - 4.7e-23 78.8 0.0 2e-05 24.6 0.0 7.0 6 1 1 7 7 7 4 Ankyrin repeat Ank_5 PF13857.6 ETO29649.1 - 8.2e-23 80.2 0.0 0.00031 21.0 0.0 6.4 5 3 1 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 ETO29649.1 - 1.7e-17 63.0 0.0 0.0001 22.6 0.0 6.0 6 1 0 6 6 6 3 Ankyrin repeat Pyr_redox_2 PF07992.14 ETO29650.1 - 0.00016 21.0 0.0 0.0017 17.7 0.0 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Macoilin PF09726.9 ETO29652.1 - 0.072 11.6 18.6 0.1 11.2 18.6 1.2 1 0 0 1 1 1 0 Macoilin family RSN1_TM PF13967.6 ETO29652.1 - 0.1 12.3 0.2 0.87 9.3 0.1 2.3 2 0 0 2 2 2 0 Late exocytosis, associated with Golgi transport SPT6_acidic PF14632.6 ETO29653.1 - 0.012 16.2 9.8 0.012 16.2 9.8 5.6 4 1 2 6 6 6 0 Acidic N-terminal SPT6 SDA1 PF05285.12 ETO29653.1 - 1.1 8.6 49.7 2.4 7.5 7.0 2.2 2 0 0 2 2 2 0 SDA1 Nucleoporin_N PF08801.11 ETO29654.1 - 1.3e-27 96.6 5.4 1.5e-27 96.5 5.4 1.0 1 0 0 1 1 1 1 Nup133 N terminal like DUF463 PF04317.12 ETO29654.1 - 0.11 11.4 0.2 9.2 5.1 0.0 2.1 2 0 0 2 2 2 0 YcjX-like family, DUF463 FBA_2 PF07735.17 ETO29656.1 - 0.043 13.9 0.8 0.1 12.7 0.1 1.9 2 0 0 2 2 2 0 F-box associated G-alpha PF00503.20 ETO29657.1 - 1.4e-20 73.8 0.2 1.8e-20 73.4 0.2 1.1 1 0 0 1 1 1 1 G-protein alpha subunit RimK PF08443.11 ETO29658.1 - 5e-31 107.8 0.0 6e-31 107.5 0.0 1.1 1 0 0 1 1 1 1 RimK-like ATP-grasp domain GSH-S_ATP PF02955.16 ETO29658.1 - 3.3e-12 46.1 0.0 4.3e-12 45.8 0.0 1.1 1 0 0 1 1 1 1 Prokaryotic glutathione synthetase, ATP-grasp domain ATP-grasp_3 PF02655.14 ETO29658.1 - 0.0011 19.0 0.0 0.0017 18.4 0.0 1.2 1 0 0 1 1 1 1 ATP-grasp domain CPSase_L_D2 PF02786.17 ETO29658.1 - 0.0075 15.8 0.0 0.01 15.3 0.0 1.2 1 0 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain COBRA1 PF06209.13 ETO29658.1 - 0.19 10.6 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Cofactor of BRCA1 (COBRA1) Pkinase PF00069.25 ETO29659.1 - 5.3e-34 117.8 2.0 9.6e-34 116.9 2.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29659.1 - 2.8e-23 82.6 0.5 4.1e-23 82.0 0.5 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO29659.1 - 1.9e-06 27.4 0.3 3.7e-06 26.4 0.3 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family CDC45 PF02724.14 ETO29659.1 - 0.044 12.1 13.4 0.058 11.7 13.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO29659.1 - 0.044 11.9 9.4 0.062 11.4 9.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen APH PF01636.23 ETO29659.1 - 0.047 13.6 0.0 0.099 12.5 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family NST1 PF13945.6 ETO29659.1 - 0.23 11.5 17.6 0.39 10.8 17.6 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator PI3K_1B_p101 PF10486.9 ETO29659.1 - 0.39 8.4 12.8 0.61 7.8 12.8 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Zip PF02535.22 ETO29659.1 - 0.63 9.2 4.8 12 5.0 6.6 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Apt1 PF10351.9 ETO29659.1 - 1.4 7.7 15.1 2.1 7.1 15.1 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain YMF19 PF02326.15 ETO29659.1 - 3.6 8.4 9.6 6.3 7.7 0.2 3.5 3 1 0 3 3 3 0 Plant ATP synthase F0 WD40 PF00400.32 ETO29660.1 - 1.6e-60 199.6 9.0 2.9e-09 37.4 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29660.1 - 3.2e-22 78.6 2.7 1.2e-05 25.6 0.1 6.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29660.1 - 2.2e-12 46.6 0.5 0.059 12.3 0.0 6.3 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29660.1 - 1.1e-06 28.2 0.1 0.017 14.5 0.0 3.6 1 1 3 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO29660.1 - 9.5e-05 22.2 7.0 6.6 6.8 0.0 5.7 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO29660.1 - 0.00033 19.7 0.8 0.83 8.5 0.0 4.3 1 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Nup160 PF11715.8 ETO29660.1 - 0.0012 17.6 0.8 3.1 6.3 0.0 3.8 2 1 1 5 5 5 1 Nucleoporin Nup120/160 Me-amine-dh_H PF06433.11 ETO29660.1 - 0.0017 17.3 0.1 0.44 9.3 0.0 3.3 2 1 3 5 5 5 2 Methylamine dehydrogenase heavy chain (MADH) DUF5570 PF17731.1 ETO29660.1 - 0.0057 16.7 2.9 16 5.6 0.0 4.1 1 1 3 4 4 4 0 Family of unknown function (DUF5570) Mid2 PF04478.12 ETO29660.1 - 0.021 14.6 0.3 2.3 8.1 0.1 3.3 2 2 2 4 4 4 0 Mid2 like cell wall stress sensor DPPIV_N PF00930.21 ETO29660.1 - 0.027 13.2 0.3 15 4.2 0.0 3.6 1 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region HARP PF07443.13 ETO29660.1 - 0.053 13.2 1.9 23 4.7 0.0 3.9 4 0 0 4 4 4 0 HepA-related protein (HARP) PQQ PF01011.21 ETO29660.1 - 0.12 12.4 0.0 28 4.9 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat N-SET PF11764.8 ETO29661.1 - 0.01 16.0 0.7 0.013 15.6 0.7 1.2 1 0 0 1 1 1 0 COMPASS (Complex proteins associated with Set1p) component N Kelch_5 PF13854.6 ETO29662.1 - 1.2e-10 41.1 10.0 0.0003 20.7 0.0 4.9 5 0 0 5 5 4 3 Kelch motif Kelch_6 PF13964.6 ETO29662.1 - 1.4e-08 34.7 9.6 0.024 14.9 0.0 5.9 6 0 0 6 6 6 3 Kelch motif Kelch_1 PF01344.25 ETO29662.1 - 1.8e-07 30.6 11.7 4e-05 23.1 0.1 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO29662.1 - 7.5e-06 25.9 9.4 0.087 12.8 0.0 5.4 6 0 0 6 6 6 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29662.1 - 1.5e-05 24.8 5.7 0.0025 17.7 0.1 4.9 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO29662.1 - 0.00014 22.0 11.2 0.028 14.7 0.1 5.4 5 0 0 5 5 5 1 Galactose oxidase, central domain PT PF04886.12 ETO29662.1 - 0.00037 20.0 13.5 0.00096 18.6 13.5 1.7 1 0 0 1 1 1 1 PT repeat SpoIIIAH PF12685.7 ETO29662.1 - 0.0052 16.6 4.0 0.0084 16.0 4.0 1.2 1 0 0 1 1 1 1 SpoIIIAH-like protein 7TM_GPCR_Srw PF10324.9 ETO29662.1 - 0.0099 15.2 0.5 0.021 14.2 0.3 1.6 2 0 0 2 2 2 1 Serpentine type 7TM GPCR chemoreceptor Srw Tub_N PF16322.5 ETO29662.1 - 0.012 16.0 0.1 0.021 15.3 0.1 1.3 1 0 0 1 1 1 0 Tubby N-terminal Ac110_PIF PF07280.11 ETO29662.1 - 0.032 14.0 1.5 0.075 12.8 1.5 1.6 1 0 0 1 1 1 0 Per os infectivity factor AC110 DUF4834 PF16118.5 ETO29662.1 - 6.5 7.8 9.0 32 5.6 9.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) AAA PF00004.29 ETO29663.1 - 1.1e-91 304.1 0.0 6.1e-48 162.6 0.0 3.0 3 0 0 3 3 2 2 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO29663.1 - 5.1e-20 71.0 0.0 1.1e-08 34.8 0.0 3.2 2 0 0 2 2 2 2 AAA+ lid domain RuvB_N PF05496.12 ETO29663.1 - 3.3e-14 52.9 0.0 8.1e-07 28.9 0.0 3.2 3 1 0 3 3 2 2 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETO29663.1 - 8.4e-13 49.1 7.3 1.5e-05 25.4 0.4 4.4 3 2 1 4 4 4 2 AAA ATPase domain AAA_2 PF07724.14 ETO29663.1 - 4.1e-12 46.6 0.0 0.00017 21.8 0.0 3.4 3 0 0 3 3 2 2 AAA domain (Cdc48 subfamily) AAA_33 PF13671.6 ETO29663.1 - 4.4e-12 46.4 0.1 0.00011 22.4 0.0 3.5 3 0 0 3 3 3 2 AAA domain AAA_22 PF13401.6 ETO29663.1 - 4.1e-10 40.1 5.6 0.011 16.0 0.3 5.5 4 2 0 4 4 3 2 AAA domain IstB_IS21 PF01695.17 ETO29663.1 - 7.5e-10 38.8 0.0 0.0015 18.3 0.0 2.5 2 0 0 2 2 2 2 IstB-like ATP binding protein AAA_5 PF07728.14 ETO29663.1 - 4.4e-09 36.5 1.6 0.0043 17.0 0.1 4.1 3 2 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETO29663.1 - 2.9e-08 34.3 1.3 0.0087 16.6 0.0 3.6 3 0 0 3 3 2 2 AAA domain AAA_14 PF13173.6 ETO29663.1 - 2.2e-07 31.0 0.0 0.02 14.9 0.0 3.4 3 0 0 3 3 3 2 AAA domain Mg_chelatase PF01078.21 ETO29663.1 - 2.9e-07 30.1 0.9 0.027 13.9 0.0 2.6 2 0 0 2 2 2 2 Magnesium chelatase, subunit ChlI TIP49 PF06068.13 ETO29663.1 - 4.1e-07 29.5 0.2 0.016 14.4 0.0 2.8 2 1 0 2 2 2 2 TIP49 P-loop domain RNA_helicase PF00910.22 ETO29663.1 - 8.7e-07 29.3 0.0 0.013 15.8 0.0 2.9 2 0 0 2 2 2 2 RNA helicase TsaE PF02367.17 ETO29663.1 - 2.1e-06 27.8 0.0 0.045 13.7 0.0 2.4 2 0 0 2 2 2 2 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_28 PF13521.6 ETO29663.1 - 4.2e-06 27.1 0.0 0.11 12.8 0.0 2.6 2 0 0 2 2 2 2 AAA domain NACHT PF05729.12 ETO29663.1 - 1.5e-05 25.0 2.5 0.14 12.1 0.0 3.5 3 1 1 4 4 3 2 NACHT domain Rad17 PF03215.15 ETO29663.1 - 3.4e-05 23.9 0.0 0.069 13.1 0.0 2.7 2 0 0 2 2 2 2 Rad17 P-loop domain ATPase PF06745.13 ETO29663.1 - 5.3e-05 22.7 0.1 0.54 9.6 0.0 3.7 3 1 0 3 3 3 2 KaiC Sigma54_activ_2 PF14532.6 ETO29663.1 - 7.5e-05 22.9 0.1 0.72 10.0 0.0 3.0 3 0 0 3 3 2 2 Sigma-54 interaction domain AAA_7 PF12775.7 ETO29663.1 - 8.7e-05 22.1 0.0 0.4 10.2 0.0 2.9 2 1 0 2 2 2 2 P-loop containing dynein motor region Viral_helicase1 PF01443.18 ETO29663.1 - 0.00011 22.0 0.2 0.62 9.8 0.0 3.0 3 0 0 3 3 2 2 Viral (Superfamily 1) RNA helicase Sigma54_activat PF00158.26 ETO29663.1 - 0.00013 21.7 0.1 0.27 10.9 0.0 3.0 3 0 0 3 3 3 2 Sigma-54 interaction domain AAA_24 PF13479.6 ETO29663.1 - 0.00016 21.4 0.0 0.49 10.1 0.0 2.9 2 0 0 2 2 2 2 AAA domain NB-ARC PF00931.22 ETO29663.1 - 0.00052 19.3 0.0 0.28 10.3 0.0 2.8 2 0 0 2 2 2 1 NB-ARC domain Zeta_toxin PF06414.12 ETO29663.1 - 0.00066 19.0 1.3 0.5 9.6 0.1 3.1 3 0 0 3 3 3 2 Zeta toxin PhoH PF02562.16 ETO29663.1 - 0.00078 19.0 0.2 0.92 8.9 0.0 2.6 2 0 0 2 2 2 2 PhoH-like protein AAA_3 PF07726.11 ETO29663.1 - 0.0013 18.6 0.0 1.4 8.8 0.0 2.5 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_25 PF13481.6 ETO29663.1 - 0.0013 18.3 7.3 1.1 8.7 0.1 4.2 2 2 1 4 4 4 2 AAA domain Cytidylate_kin2 PF13189.6 ETO29663.1 - 0.0018 18.5 0.1 1.2 9.3 0.0 2.9 3 0 0 3 3 2 1 Cytidylate kinase-like family AAA_17 PF13207.6 ETO29663.1 - 0.0022 18.4 9.5 0.44 11.0 0.0 4.4 3 1 1 4 4 4 2 AAA domain DUF815 PF05673.13 ETO29663.1 - 0.0028 16.9 0.0 0.17 11.0 0.0 3.2 3 1 0 3 3 3 1 Protein of unknown function (DUF815) SRPRB PF09439.10 ETO29663.1 - 0.0044 16.5 0.9 4.6 6.6 0.0 3.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit ABC_tran PF00005.27 ETO29663.1 - 0.0069 16.9 10.0 0.29 11.7 0.0 3.7 3 2 0 4 4 2 2 ABC transporter CPT PF07931.12 ETO29663.1 - 0.0094 15.8 0.0 0.97 9.3 0.0 2.5 2 0 0 2 2 2 1 Chloramphenicol phosphotransferase-like protein AAA_19 PF13245.6 ETO29663.1 - 0.01 16.2 5.1 7.8 6.8 0.0 3.8 4 1 0 4 4 3 0 AAA domain Vps4_C PF09336.10 ETO29663.1 - 0.01 15.8 0.9 0.36 10.8 0.0 3.1 3 0 0 3 3 2 0 Vps4 C terminal oligomerisation domain TniB PF05621.11 ETO29663.1 - 0.032 13.6 0.0 3.1 7.1 0.0 3.2 3 1 0 3 3 3 0 Bacterial TniB protein AAA_29 PF13555.6 ETO29663.1 - 0.039 13.7 0.0 10 5.9 0.0 2.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain AAA_30 PF13604.6 ETO29663.1 - 0.049 13.3 0.3 8.2 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain Cytidylate_kin PF02224.18 ETO29663.1 - 0.055 13.2 0.4 11 5.6 0.0 2.7 2 0 0 2 2 2 0 Cytidylate kinase ATPase_2 PF01637.18 ETO29663.1 - 0.08 12.8 7.2 0.19 11.6 0.0 4.2 3 2 0 4 4 3 0 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 ETO29663.1 - 0.094 12.5 0.0 22 4.8 0.0 2.7 2 0 0 2 2 2 0 Ethanolamine utilisation - propanediol utilisation Hydin_ADK PF17213.3 ETO29663.1 - 0.53 10.5 0.0 0.53 10.5 0.0 4.0 3 1 0 3 3 2 0 Hydin Adenylate kinase-like domain SR-25 PF10500.9 ETO29665.1 - 0.019 14.6 11.5 0.032 13.8 11.5 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Neur_chan_memb PF02932.16 ETO29665.1 - 0.13 12.3 3.3 0.15 12.1 3.3 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DNA_pol_phi PF04931.13 ETO29665.1 - 6.8 4.7 17.6 8.8 4.3 17.6 1.2 1 0 0 1 1 1 0 DNA polymerase phi LRIF1 PF15741.5 ETO29665.1 - 7.6 4.9 10.9 8.4 4.8 10.9 1.0 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 S1 PF00575.23 ETO29667.1 - 5.2e-16 58.7 0.0 4.3e-08 33.4 0.0 2.5 2 0 0 2 2 2 2 S1 RNA binding domain F-box PF00646.33 ETO29667.1 - 0.00011 22.0 0.4 0.00022 21.0 0.4 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO29667.1 - 0.015 15.2 0.0 0.027 14.3 0.0 1.4 1 0 0 1 1 1 0 F-box-like S1_2 PF13509.6 ETO29667.1 - 0.057 13.5 0.0 8.6 6.5 0.0 3.2 3 0 0 3 3 3 0 S1 domain CDC45 PF02724.14 ETO29667.1 - 1.5 7.1 17.4 1.7 6.9 17.4 1.2 1 0 0 1 1 1 0 CDC45-like protein Hid1 PF12722.7 ETO29667.1 - 7.8 4.5 11.7 11 4.1 11.7 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SHR-BD PF06650.12 ETO29668.1 - 1.1e-10 41.3 2.4 1.4e-06 27.9 0.4 3.0 2 1 0 2 2 2 2 SHR-binding domain of vacuolar-sorting associated protein 13 UPF0561 PF10573.9 ETO29668.1 - 0.061 13.4 0.9 0.12 12.5 0.9 1.5 1 0 0 1 1 1 0 Uncharacterised protein family UPF0561 Pex24p PF06398.11 ETO29668.1 - 4.1 6.3 16.7 29 3.5 13.6 2.8 2 1 0 2 2 2 0 Integral peroxisomal membrane peroxin zf-TRAF PF02176.18 ETO29669.1 - 6.2e-07 30.0 1.8 6.2e-07 30.0 1.8 3.0 4 0 0 4 4 4 1 TRAF-type zinc finger Cathelicidins PF00666.17 ETO29669.1 - 0.22 11.8 0.2 0.22 11.8 0.2 2.5 3 1 1 4 4 4 0 Cathelicidin WD40 PF00400.32 ETO29671.1 - 1.1e-42 143.2 17.5 3.3e-07 30.9 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29671.1 - 4.2e-18 65.4 2.1 0.003 17.8 0.0 5.9 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29671.1 - 9.5e-09 34.6 0.1 0.31 10.0 0.0 5.0 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO29671.1 - 1.7e-08 34.2 3.5 0.43 10.6 0.0 5.0 5 1 0 5 5 5 3 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO29671.1 - 9.9e-08 31.7 3.8 0.011 15.1 0.3 2.9 2 1 1 3 3 3 3 WD40-like domain Coatomer_WDAD PF04053.14 ETO29671.1 - 1.8e-06 27.3 0.1 0.00098 18.3 0.0 2.0 1 1 1 2 2 2 2 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO29671.1 - 5.7e-05 21.8 0.3 0.026 13.1 0.1 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nup160 PF11715.8 ETO29671.1 - 0.00088 18.0 2.0 2.7 6.5 0.1 4.2 3 1 0 4 4 4 1 Nucleoporin Nup120/160 Me-amine-dh_H PF06433.11 ETO29671.1 - 0.0077 15.1 0.0 0.034 13.0 0.0 1.9 2 0 0 2 2 2 1 Methylamine dehydrogenase heavy chain (MADH) PALB2_WD40 PF16756.5 ETO29671.1 - 0.0084 15.1 3.8 2 7.3 0.0 4.0 2 2 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETO29671.1 - 0.044 13.5 3.4 25 4.7 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature VID27 PF08553.10 ETO29671.1 - 0.098 11.7 0.1 4.1 6.4 0.0 2.7 1 1 1 3 3 3 0 VID27 C-terminal WD40-like domain TIMELESS_C PF05029.13 ETO29672.1 - 0.0075 15.5 16.2 0.012 14.9 16.2 1.2 1 0 0 1 1 1 1 Timeless protein C terminal region Merozoite_SPAM PF07133.11 ETO29672.1 - 0.017 15.1 23.3 0.04 13.9 23.3 1.6 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Nop14 PF04147.12 ETO29672.1 - 0.025 12.8 18.9 0.041 12.1 18.9 1.2 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ETO29672.1 - 0.042 14.0 24.6 0.081 13.0 24.6 1.4 1 0 0 1 1 1 0 YL1 nuclear protein TFIIF_alpha PF05793.12 ETO29672.1 - 0.18 10.4 24.8 0.27 9.8 24.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) CDC45 PF02724.14 ETO29672.1 - 0.39 9.0 23.5 0.59 8.3 23.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Pkinase PF00069.25 ETO29673.1 - 3.6e-08 33.1 0.0 9.2e-07 28.5 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain G-patch PF01585.23 ETO29676.1 - 5.2e-10 39.0 5.6 2.2e-09 37.0 5.4 2.1 1 1 0 1 1 1 1 G-patch domain G-patch_2 PF12656.7 ETO29676.1 - 0.27 11.4 7.6 0.13 12.3 4.4 2.1 2 1 0 2 2 2 0 G-patch domain Pkinase PF00069.25 ETO29677.1 - 4.8e-55 186.8 0.0 5.8e-55 186.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29677.1 - 4.6e-23 81.8 0.0 5.5e-23 81.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO29677.1 - 0.00021 20.7 0.0 0.00027 20.4 0.0 1.3 1 0 0 1 1 1 1 Kinase-like Haspin_kinase PF12330.8 ETO29677.1 - 0.019 13.9 0.1 0.078 11.9 0.0 1.9 2 0 0 2 2 2 0 Haspin like kinase domain APH PF01636.23 ETO29677.1 - 0.061 13.2 0.0 0.084 12.8 0.0 1.2 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kdo PF06293.14 ETO29677.1 - 0.072 12.4 0.1 0.14 11.5 0.1 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Seadorna_VP7 PF07387.11 ETO29677.1 - 0.088 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 Seadornavirus VP7 GreA_GreB PF01272.19 ETO29678.1 - 0.035 14.0 0.0 0.056 13.3 0.0 1.2 1 0 0 1 1 1 0 Transcription elongation factor, GreA/GreB, C-term HEPN-like_int PF18867.1 ETO29678.1 - 0.04 13.8 0.1 0.048 13.5 0.1 1.1 1 0 0 1 1 1 0 HEPN-like integron domain Acetyltransf_1 PF00583.25 ETO29679.1 - 3.3e-15 56.4 0.0 4.2e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_7 PF13508.7 ETO29679.1 - 4.3e-12 46.3 0.0 7e-12 45.6 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO29679.1 - 6.8e-12 45.4 0.0 1.5e-11 44.3 0.0 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_9 PF13527.7 ETO29679.1 - 0.0004 20.5 0.0 0.00064 19.8 0.0 1.5 1 1 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_16 PF05301.11 ETO29679.1 - 0.0034 17.2 0.0 0.0045 16.8 0.0 1.2 1 0 0 1 1 1 1 GNAT acetyltransferase, Mec-17 Q_salvage PF10343.9 ETO29679.1 - 0.0059 16.2 0.2 0.0089 15.6 0.2 1.2 1 0 0 1 1 1 1 Potential Queuosine, Q, salvage protein family GNAT_acetyltr_2 PF13718.6 ETO29679.1 - 0.054 12.9 0.0 0.077 12.4 0.0 1.4 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Acetyltransf_4 PF13420.7 ETO29679.1 - 0.082 13.0 0.2 0.18 11.9 0.0 1.6 2 0 0 2 2 2 0 Acetyltransferase (GNAT) domain Acetyltransf_13 PF13880.6 ETO29679.1 - 0.087 12.8 0.0 0.16 12.0 0.0 1.4 1 0 0 1 1 1 0 ESCO1/2 acetyl-transferase FR47 PF08445.10 ETO29679.1 - 0.15 12.1 0.0 0.29 11.1 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Kelch_1 PF01344.25 ETO29680.1 - 7.1e-09 35.1 0.3 8.7e-06 25.2 0.1 3.3 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO29680.1 - 2.7e-08 33.8 1.7 0.017 15.4 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO29680.1 - 3.1e-07 30.3 5.0 0.0045 17.0 0.1 4.3 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO29680.1 - 1.3e-05 25.3 1.5 0.83 10.0 0.0 3.6 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29680.1 - 0.00081 19.3 1.2 0.06 13.3 0.2 3.4 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO29680.1 - 0.002 18.1 1.6 0.88 9.6 0.1 3.2 3 0 0 3 3 3 2 Kelch motif AAA_6 PF12774.7 ETO29681.1 - 1.6e-42 145.6 1.6 1e-33 116.7 0.0 2.3 2 1 0 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_16 PF13191.6 ETO29681.1 - 0.012 16.0 0.3 0.1 13.0 0.0 2.3 2 1 1 3 3 3 0 AAA ATPase domain RsgA_GTPase PF03193.16 ETO29681.1 - 0.014 15.3 0.3 0.026 14.4 0.3 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_18 PF13238.6 ETO29681.1 - 0.021 15.4 0.0 0.22 12.1 0.0 2.5 3 0 0 3 3 3 0 AAA domain Katanin_con80 PF13925.6 ETO29681.1 - 0.027 14.5 0.0 0.05 13.6 0.0 1.4 1 0 0 1 1 1 0 con80 domain of Katanin ATPase_2 PF01637.18 ETO29681.1 - 0.049 13.6 0.0 0.11 12.4 0.0 1.6 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea RNA_helicase PF00910.22 ETO29681.1 - 0.072 13.5 0.0 0.2 12.1 0.0 1.7 1 0 0 1 1 1 0 RNA helicase FlaC_arch PF05377.11 ETO29681.1 - 0.083 13.3 0.1 0.2 12.1 0.1 1.6 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) MMR_HSR1 PF01926.23 ETO29681.1 - 0.094 12.8 0.0 0.25 11.4 0.0 1.7 1 0 0 1 1 1 0 50S ribosome-binding GTPase DHC_N2 PF08393.13 ETO29682.1 - 4.6e-84 282.8 9.5 4.6e-84 282.8 9.5 1.9 3 0 0 3 3 3 1 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 ETO29682.1 - 1.6e-57 194.9 0.0 4e-57 193.7 0.0 1.6 1 0 0 1 1 1 1 Hydrolytic ATP binding site of dynein motor region AAA_24 PF13479.6 ETO29682.1 - 0.0015 18.3 0.0 0.024 14.4 0.0 2.6 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO29682.1 - 0.022 14.8 0.1 0.29 11.1 0.0 2.9 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO29682.1 - 0.09 13.2 1.8 0.8 10.1 0.2 3.1 3 2 0 3 3 3 0 AAA ATPase domain AAA PF00004.29 ETO29682.1 - 0.098 13.1 0.0 0.39 11.1 0.0 2.1 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO29682.1 - 0.11 13.0 1.0 2.2 8.8 0.0 3.1 4 0 0 4 4 4 0 AAA domain DASH_Dam1 PF08653.10 ETO29682.1 - 0.26 11.1 3.3 7 6.5 0.0 3.5 3 0 0 3 3 3 0 DASH complex subunit Dam1 ING PF12998.7 ETO29682.1 - 0.36 11.4 6.3 1.6 9.4 0.0 4.1 4 1 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding SesA PF17107.5 ETO29682.1 - 0.74 10.0 3.5 13 6.0 0.2 3.7 4 1 1 5 5 5 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Glutaredoxin2_C PF04399.13 ETO29682.1 - 0.79 9.6 3.9 22 4.9 0.2 3.6 2 1 1 3 3 3 0 Glutaredoxin 2, C terminal domain AAA_22 PF13401.6 ETO29682.1 - 0.86 9.9 3.9 0.75 10.1 0.1 2.9 3 1 0 3 3 3 0 AAA domain Cob_adeno_trans PF01923.18 ETO29682.1 - 1.6 8.9 3.7 62 3.7 0.1 3.9 3 1 1 4 4 4 0 Cobalamin adenosyltransferase MIT PF04212.18 ETO29683.1 - 0.075 13.1 3.9 1.8 8.7 0.1 3.7 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain RBFA PF02033.18 ETO29683.1 - 1.1 9.7 8.2 2.4 8.7 0.3 3.6 4 0 0 4 4 4 0 Ribosome-binding factor A Xpo1 PF08389.12 ETO29683.1 - 1.4 9.0 8.4 0.12 12.4 0.7 3.0 3 0 0 3 3 3 0 Exportin 1-like protein DHC_N1 PF08385.12 ETO29684.1 - 6.5e-14 51.5 2.8 7.3e-14 51.3 2.8 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 T3SchapCesA PF11439.8 ETO29684.1 - 0.041 14.0 0.7 0.077 13.1 0.2 1.9 2 1 0 2 2 2 0 Type III secretion system filament chaperone CesA DUF2990 PF11693.8 ETO29684.1 - 0.17 12.1 0.7 19 5.5 0.2 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF2990) Sporozoite_P67 PF05642.11 ETO29686.1 - 0.11 10.6 9.5 0.15 10.1 9.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen NOA36 PF06524.12 ETO29686.1 - 0.35 10.2 15.5 0.46 9.8 15.5 1.2 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO29686.1 - 1.2 7.2 16.2 4.1 5.4 15.2 1.9 2 0 0 2 2 2 0 DNA polymerase phi DUF2457 PF10446.9 ETO29686.1 - 1.4 8.0 22.3 1.8 7.6 22.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Pox_Ag35 PF03286.14 ETO29686.1 - 2.4 7.9 11.0 3.7 7.3 11.0 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CDC45 PF02724.14 ETO29686.1 - 3.9 5.7 14.5 4.6 5.4 14.5 1.1 1 0 0 1 1 1 0 CDC45-like protein RRN3 PF05327.11 ETO29686.1 - 9.6 4.6 10.6 16 3.9 10.6 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Kelch_6 PF13964.6 ETO29688.1 - 9.4e-10 38.4 2.7 8e-06 25.9 0.6 2.4 1 1 1 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO29688.1 - 2.5e-06 27.0 0.5 7.5e-05 22.2 0.2 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO29688.1 - 2.1e-05 24.4 0.2 0.0061 16.5 0.1 2.3 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29688.1 - 3.8e-05 23.5 0.3 0.0011 18.9 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO29688.1 - 0.00023 21.1 3.4 0.019 14.9 1.7 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO29688.1 - 0.001 19.3 0.0 0.0052 17.0 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain DUF2681 PF10883.8 ETO29689.1 - 0.35 11.3 0.0 0.35 11.3 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2681) OSTbeta PF15048.6 ETO29689.1 - 0.68 10.1 5.8 1 9.5 5.8 1.5 1 1 0 1 1 1 0 Organic solute transporter subunit beta protein Peptidase_S49_N PF08496.10 ETO29689.1 - 6.3 6.8 8.8 7.7 6.6 8.6 1.4 1 1 0 1 1 1 0 Peptidase family S49 N-terminal SIX1_SD PF16878.5 ETO29690.1 - 0.0056 17.2 0.3 0.023 15.2 0.3 2.1 1 0 0 1 1 1 1 Transcriptional regulator, SIX1, N-terminal SD domain Nop14 PF04147.12 ETO29690.1 - 0.21 9.8 44.5 0.28 9.3 36.3 2.5 2 0 0 2 2 2 0 Nop14-like family PSD1 PF07587.11 ETO29691.1 - 0.0015 18.1 0.6 0.0018 17.9 0.6 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1553) DUF4554 PF15091.6 ETO29691.1 - 0.14 11.1 1.6 0.15 10.9 1.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4554) Rrn6 PF10214.9 ETO29692.1 - 2 6.8 30.8 2.6 6.5 30.8 1.1 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor TFIIA PF03153.13 ETO29692.1 - 2.9 7.8 39.3 3.7 7.4 39.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 ETO29692.1 - 3.6 4.6 25.9 4.3 4.3 25.9 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SOG2 PF10428.9 ETO29692.1 - 4.6 6.3 32.5 7.4 5.6 32.5 1.3 1 0 0 1 1 1 0 RAM signalling pathway protein DUF3605 PF12239.8 ETO29693.1 - 6.9e-15 55.7 8.8 3.5e-12 46.9 2.1 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF3605) NYD-SP28_assoc PF14775.6 ETO29693.1 - 1.1 9.4 5.9 0.21 11.7 1.4 2.1 2 1 0 2 2 2 0 Sperm tail C-terminal domain Pkinase PF00069.25 ETO29694.1 - 1.6e-42 145.7 3.5 2.1e-36 125.7 1.7 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29694.1 - 7.1e-19 68.1 3.1 3.2e-18 66.0 0.8 2.1 1 1 1 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO29694.1 - 0.0072 15.7 0.1 0.014 14.7 0.1 1.5 1 0 0 1 1 1 1 Kinase-like DHC_N2 PF08393.13 ETO29694.1 - 0.014 14.6 0.9 2 7.5 0.3 2.2 2 0 0 2 2 2 0 Dynein heavy chain, N-terminal region 2 Pkinase_fungal PF17667.1 ETO29694.1 - 0.025 13.4 0.6 0.053 12.3 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase SAM_1 PF00536.30 ETO29696.1 - 4.7e-08 33.4 0.1 6.8e-08 32.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO29696.1 - 3.7e-07 30.1 0.1 6.2e-07 29.4 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO29696.1 - 0.00045 20.4 0.1 0.0046 17.2 0.0 2.1 1 1 1 2 2 2 1 Ste50p, sterile alpha motif Na_trans_assoc PF06512.13 ETO29696.1 - 0.016 15.5 0.3 0.016 15.5 0.3 1.2 1 0 0 1 1 1 0 Sodium ion transport-associated DNA_pol_phi PF04931.13 ETO29696.1 - 1.7 6.6 5.6 2.6 6.0 5.4 1.3 2 0 0 2 2 2 0 DNA polymerase phi FRP PF18032.1 ETO29697.1 - 0.0004 21.0 0.1 0.00041 20.9 0.1 1.1 1 0 0 1 1 1 1 Photoprotection regulator fluorescence recovery protein NUC129 PF08157.11 ETO29698.1 - 0.11 12.9 0.0 0.48 10.8 0.0 2.0 2 0 0 2 2 2 0 NUC129 domain zf-TRAF PF02176.18 ETO29699.1 - 1e-05 26.1 4.3 1e-05 26.1 4.3 2.5 3 0 0 3 3 3 1 TRAF-type zinc finger Ribosomal_L28 PF00830.19 ETO29701.1 - 0.098 12.9 19.7 1.4 9.2 1.0 3.5 1 1 2 3 3 3 0 Ribosomal L28 family zf-C2H2 PF00096.26 ETO29702.1 - 0.00025 21.4 7.6 0.0029 17.9 1.4 4.9 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO29702.1 - 0.00072 20.2 22.7 0.012 16.4 1.4 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO29702.1 - 0.0017 18.7 27.4 0.0038 17.6 1.6 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ETO29702.1 - 1 9.4 11.6 0.36 10.9 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger HypA PF01155.19 ETO29702.1 - 9.2 6.3 11.4 24 5.0 8.0 2.5 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Lung_7-TM_R PF06814.13 ETO29703.1 - 3.7e-10 39.5 9.9 3.7e-10 39.5 9.9 2.3 3 0 0 3 3 3 1 Lung seven transmembrane receptor GpcrRhopsn4 PF10192.9 ETO29703.1 - 1.4e-08 34.5 4.9 1.4e-08 34.5 4.9 2.7 4 0 0 4 4 4 1 Rhodopsin-like GPCR transmembrane domain FtsL PF04999.13 ETO29703.1 - 0.095 12.7 0.1 0.31 11.1 0.1 1.8 1 0 0 1 1 1 0 Cell division protein FtsL ELFV_dehydrog_N PF02812.18 ETO29704.1 - 1.1e-50 170.9 0.0 2e-50 170.1 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 ETO29704.1 - 4.6e-50 170.6 0.1 6.6e-50 170.1 0.1 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase 2-Hacid_dh_C PF02826.19 ETO29704.1 - 0.019 14.3 0.0 0.038 13.4 0.0 1.4 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain AdoHcyase_NAD PF00670.21 ETO29704.1 - 0.035 14.2 0.0 0.075 13.1 0.0 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain DUF3523 PF12037.8 ETO29705.1 - 4.8e-35 121.2 18.9 1.3e-31 110.0 15.9 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF3523) AAA PF00004.29 ETO29705.1 - 2e-21 76.8 0.0 4.3e-21 75.7 0.0 1.6 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO29705.1 - 3e-06 27.1 0.0 7.3e-06 25.8 0.0 1.7 1 1 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETO29705.1 - 0.0001 22.6 0.0 0.025 14.9 0.0 3.0 3 0 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ETO29705.1 - 0.00011 22.6 1.4 0.00044 20.7 0.0 2.6 2 1 0 2 2 2 1 AAA ATPase domain AAA_24 PF13479.6 ETO29705.1 - 0.0011 18.7 0.0 0.0033 17.2 0.0 1.8 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO29705.1 - 0.0046 17.0 3.0 0.013 15.5 0.1 2.9 2 2 0 2 2 2 1 AAA domain (dynein-related subfamily) Sigma54_activ_2 PF14532.6 ETO29705.1 - 0.0095 16.1 0.0 0.022 14.9 0.0 1.6 1 0 0 1 1 1 1 Sigma-54 interaction domain RNA_helicase PF00910.22 ETO29705.1 - 0.029 14.8 0.0 0.074 13.4 0.0 1.7 1 0 0 1 1 1 0 RNA helicase Mg_chelatase PF01078.21 ETO29705.1 - 0.041 13.2 0.0 0.22 10.9 0.0 2.1 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ETO29705.1 - 0.068 13.7 4.9 0.08 13.5 0.0 2.6 2 0 0 2 2 2 0 AAA domain AAA_17 PF13207.6 ETO29705.1 - 0.52 10.7 0.0 0.52 10.7 0.0 2.9 2 0 0 2 2 2 0 AAA domain AAA_11 PF13086.6 ETO29705.1 - 1.1 9.0 0.0 1.1 9.0 0.0 2.6 2 1 0 2 2 1 0 AAA domain POX PF07526.11 ETO29706.1 - 0.22 12.1 3.7 0.22 12.1 0.6 2.2 2 0 0 2 2 2 0 Associated with HOX Cwf_Cwc_15 PF04889.12 ETO29706.1 - 1.7 8.3 14.2 1.3 8.7 4.7 2.2 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein NOA36 PF06524.12 ETO29706.1 - 3.3 6.9 14.3 2.1 7.6 0.2 2.2 2 0 0 2 2 2 0 NOA36 protein Ribonuclease PF00545.20 ETO29707.1 - 0.093 13.5 0.2 0.16 12.8 0.2 1.3 1 0 0 1 1 1 0 ribonuclease WD40 PF00400.32 ETO29708.1 - 2.2e-42 142.2 21.2 3.3e-06 27.7 0.2 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29708.1 - 1.1e-13 51.2 0.1 0.004 17.4 0.0 5.7 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29708.1 - 3.6e-12 45.7 3.4 0.18 10.4 0.0 5.9 3 2 3 6 6 6 5 Nucleoporin Nup120/160 PQQ_3 PF13570.6 ETO29708.1 - 0.039 14.4 0.7 39 4.9 0.0 4.7 5 1 0 5 5 5 0 PQQ-like domain WD40 PF00400.32 ETO29709.1 - 1.2e-63 209.5 19.5 1.2e-11 44.9 0.3 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29709.1 - 4.5e-25 87.8 2.3 0.00011 22.4 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29709.1 - 2.1e-12 46.7 3.6 0.15 11.0 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO29709.1 - 1.2e-08 34.7 0.3 0.012 15.0 0.3 3.1 2 1 1 3 3 3 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO29709.1 - 2e-06 26.6 0.3 0.57 8.7 0.0 3.1 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO29709.1 - 4.9e-05 23.2 6.0 0.8 9.7 0.0 5.9 7 0 0 7 7 6 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO29709.1 - 0.0084 16.2 1.8 11 6.1 0.0 4.7 2 1 4 6 6 6 1 Family of unknown function (DUF5570) SGL PF08450.12 ETO29709.1 - 0.035 13.7 0.1 0.65 9.5 0.0 2.5 1 1 1 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region BBS2_Mid PF14783.6 ETO29709.1 - 0.095 12.7 3.7 11 6.2 0.2 4.4 3 1 1 4 4 3 0 Ciliary BBSome complex subunit 2, middle region DUF1513 PF07433.11 ETO29709.1 - 0.18 10.9 0.1 17 4.4 0.0 3.2 1 1 3 4 4 4 0 Protein of unknown function (DUF1513) Resistin PF06954.11 ETO29709.1 - 0.46 11.1 4.5 23 5.6 0.0 4.4 2 1 4 6 6 6 0 Resistin F-box-like PF12937.7 ETO29710.1 - 6.9e-05 22.7 0.1 0.00015 21.6 0.1 1.6 1 0 0 1 1 1 1 F-box-like F-box PF00646.33 ETO29710.1 - 0.0016 18.2 0.1 0.004 17.0 0.1 1.6 1 0 0 1 1 1 1 F-box domain PRANC PF09372.10 ETO29710.1 - 1.4 9.3 7.0 1.3 9.4 1.0 3.2 2 1 0 3 3 3 0 PRANC domain SAP PF02037.27 ETO29711.1 - 1.8e-08 33.9 0.4 3.6e-08 33.0 0.4 1.5 1 0 0 1 1 1 1 SAP domain CLZ PF16526.5 ETO29712.1 - 0.032 14.6 2.4 0.72 10.3 1.6 3.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Aminotran_3 PF00202.21 ETO29712.1 - 0.045 12.4 0.6 0.078 11.6 0.1 1.6 2 0 0 2 2 2 0 Aminotransferase class-III bZIP_2 PF07716.15 ETO29712.1 - 1.1 9.3 7.1 2 8.6 2.1 3.1 2 0 0 2 2 2 0 Basic region leucine zipper Pkinase PF00069.25 ETO29714.1 - 1.5e-47 162.2 0.1 1e-45 156.2 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29714.1 - 3.9e-16 59.1 0.1 1.3e-15 57.4 0.1 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase 7TM_GPCR_Srab PF10292.9 ETO29714.1 - 0.031 13.2 1.8 0.049 12.5 1.8 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR receptor class ab chemoreceptor Kinase-like PF14531.6 ETO29714.1 - 0.066 12.5 0.1 1.4 8.2 0.2 2.1 2 0 0 2 2 2 0 Kinase-like LRR_4 PF12799.7 ETO29715.1 - 0.0066 16.8 2.9 0.0066 16.8 2.9 4.6 5 0 0 5 5 5 1 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO29715.1 - 0.0091 15.7 16.0 0.019 14.7 2.8 5.0 5 0 0 5 5 5 1 Leucine rich repeat WBP-1 PF11669.8 ETO29715.1 - 0.034 14.8 0.4 0.034 14.8 0.4 2.1 1 1 1 2 2 2 0 WW domain-binding protein 1 TMEM52 PF14979.6 ETO29715.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Transmembrane 52 LRR_6 PF13516.6 ETO29715.1 - 0.39 10.9 7.3 36 4.8 0.2 5.0 5 0 0 5 5 5 0 Leucine Rich repeat LRR_1 PF00560.33 ETO29715.1 - 1.9 9.3 15.3 47 5.1 0.1 5.9 4 1 0 4 4 4 0 Leucine Rich Repeat FtsL PF04999.13 ETO29716.1 - 0.089 12.8 1.7 0.22 11.5 1.7 1.7 1 1 0 1 1 1 0 Cell division protein FtsL CAF1C_H4-bd PF12265.8 ETO29717.1 - 4.5e-23 81.3 0.2 1.5e-22 79.7 0.2 2.0 1 0 0 1 1 1 1 Histone-binding protein RBBP4 or subunit C of CAF1 complex WD40 PF00400.32 ETO29717.1 - 5.6e-22 77.6 16.3 0.00058 20.6 0.1 5.6 5 0 0 5 5 5 5 WD domain, G-beta repeat B56 PF01603.20 ETO29718.1 - 1.4e-56 192.3 28.2 5.2e-49 167.3 5.3 3.8 3 1 0 3 3 3 2 Protein phosphatase 2A regulatory B subunit (B56 family) TFIIA PF03153.13 ETO29718.1 - 3.1 7.7 61.5 0.21 11.6 28.2 3.1 3 0 0 3 3 3 0 Transcription factor IIA, alpha/beta subunit HAUS5 PF14817.6 ETO29720.1 - 0.0068 15.2 9.5 0.0068 15.2 9.5 2.0 1 1 0 2 2 2 1 HAUS augmin-like complex subunit 5 CorA PF01544.18 ETO29720.1 - 7.1 5.9 17.1 3.5 6.8 4.3 2.4 2 1 0 2 2 2 0 CorA-like Mg2+ transporter protein PA26 PF04636.13 ETO29722.1 - 4 6.3 12.1 7.9 5.3 12.1 1.5 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Pox_Ag35 PF03286.14 ETO29723.1 - 0.0034 17.2 8.1 0.0034 17.2 8.1 2.8 2 1 0 2 2 2 1 Pox virus Ag35 surface protein Tim54 PF11711.8 ETO29723.1 - 0.22 10.2 17.1 0.15 10.9 1.7 2.1 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Hira PF07569.11 ETO29723.1 - 0.24 11.1 0.0 0.24 11.1 0.0 2.5 3 0 0 3 3 3 0 TUP1-like enhancer of split Presenilin PF01080.17 ETO29723.1 - 1.8 7.2 24.9 2.4 6.8 9.6 2.1 2 0 0 2 2 2 0 Presenilin CNDH2_C PF16858.5 ETO29723.1 - 2.5 7.9 26.4 4.8 7.0 10.3 2.3 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term CDC45 PF02724.14 ETO29723.1 - 3.5 5.8 30.6 0.077 11.3 9.3 2.2 2 0 0 2 2 2 0 CDC45-like protein Vfa1 PF08432.10 ETO29723.1 - 4.8 7.5 31.5 4.6 7.5 10.2 2.5 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Band_3_cyto PF07565.13 ETO29724.1 - 0.00013 21.9 6.3 0.00019 21.4 6.3 1.3 1 0 0 1 1 1 1 Band 3 cytoplasmic domain Med3 PF11593.8 ETO29724.1 - 0.0071 15.6 15.2 0.0071 15.6 15.2 1.5 1 1 1 2 2 2 1 Mediator complex subunit 3 fungal PARM PF17061.5 ETO29724.1 - 0.025 14.7 16.7 0.031 14.4 16.7 1.1 1 0 0 1 1 1 0 PARM Dicty_REP PF05086.12 ETO29724.1 - 0.065 11.2 10.9 0.083 10.9 10.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DDHD PF02862.17 ETO29724.1 - 0.08 13.1 6.8 0.12 12.5 6.8 1.4 1 0 0 1 1 1 0 DDHD domain TFIIA PF03153.13 ETO29724.1 - 0.1 12.6 13.5 0.13 12.2 13.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit SR-25 PF10500.9 ETO29724.1 - 0.18 11.4 22.1 0.33 10.5 22.1 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein FAM60A PF15396.6 ETO29724.1 - 0.33 10.9 8.3 0.59 10.1 8.3 1.4 1 0 0 1 1 1 0 Protein Family FAM60A Macoilin PF09726.9 ETO29724.1 - 0.34 9.4 16.5 0.4 9.2 16.5 1.1 1 0 0 1 1 1 0 Macoilin family DUF3807 PF12720.7 ETO29724.1 - 0.45 10.8 12.2 0.77 10.0 12.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) DHHW PF14286.6 ETO29724.1 - 0.62 9.3 6.2 0.84 8.9 6.2 1.2 1 0 0 1 1 1 0 DHHW protein Suf PF05843.14 ETO29724.1 - 0.77 9.7 11.5 1.1 9.1 11.5 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) CCDC53 PF10152.9 ETO29724.1 - 1.1 9.7 12.1 2 8.8 12.1 1.4 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex XRN_M PF17846.1 ETO29724.1 - 1.3 7.9 7.9 1.8 7.4 7.9 1.1 1 0 0 1 1 1 0 Xrn1 helical domain Presenilin PF01080.17 ETO29724.1 - 2.4 6.9 14.7 3.1 6.5 14.7 1.1 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 ETO29724.1 - 4.1 8.1 15.3 7 7.3 15.3 1.4 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region SPX PF03105.19 ETO29724.1 - 5.3 6.9 17.9 7.9 6.3 17.9 1.2 1 0 0 1 1 1 0 SPX domain WD40 PF00400.32 ETO29725.1 - 4.3e-41 138.1 4.7 7.8e-10 39.2 0.0 6.6 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29725.1 - 2.9e-16 59.5 0.9 8.1e-06 26.1 0.0 5.1 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29725.1 - 6.2e-13 48.7 1.5 0.0003 20.2 0.0 3.0 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO29725.1 - 6.9e-09 35.1 0.8 0.02 13.9 0.0 5.3 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO29725.1 - 1.8e-07 31.2 0.3 0.00033 20.6 0.0 3.5 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO29725.1 - 8.3e-07 28.8 0.1 0.89 9.6 0.0 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Utp8 PF10395.9 ETO29725.1 - 0.00046 18.8 0.9 4.1 5.8 0.0 3.7 1 1 2 3 3 3 2 Utp8 family Nup160 PF11715.8 ETO29725.1 - 0.001 17.8 3.4 0.72 8.4 0.0 3.8 1 1 2 3 3 3 1 Nucleoporin Nup120/160 B_lectin PF01453.24 ETO29725.1 - 0.0022 18.5 0.1 2.4 8.8 0.0 2.9 2 2 0 2 2 2 2 D-mannose binding lectin Frtz PF11768.8 ETO29725.1 - 0.0022 16.4 0.6 0.094 11.0 0.0 2.2 2 0 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Nbas_N PF15492.6 ETO29725.1 - 0.012 15.0 0.2 0.32 10.3 0.1 3.0 1 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO29725.1 - 0.016 13.7 0.1 0.36 9.3 0.0 2.5 1 1 1 3 3 3 0 Cytochrome D1 heme domain Hira PF07569.11 ETO29725.1 - 0.045 13.5 1.2 5.6 6.6 0.0 3.7 3 1 1 4 4 4 0 TUP1-like enhancer of split Proteasome_A_N PF10584.9 ETO29725.1 - 0.07 12.8 2.3 22 4.8 0.1 3.6 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO29726.1 - 3.7e-38 128.8 28.3 9.7e-07 29.4 0.7 7.3 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29726.1 - 1.4e-12 47.7 2.0 0.063 13.6 0.0 5.9 3 2 1 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29726.1 - 8.9e-07 27.9 5.8 0.75 8.4 0.2 4.6 3 2 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29726.1 - 2.3e-05 23.9 14.5 0.043 13.2 0.3 4.4 2 2 0 4 4 4 2 WD40-like domain SH3_13 PF18335.1 ETO29726.1 - 0.039 13.8 4.3 0.091 12.6 0.2 3.4 4 1 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain DUF4979 PF16351.5 ETO29726.1 - 0.047 13.9 8.4 1 9.6 0.5 3.8 2 2 1 3 3 3 0 Domain of unknown function (DUF4979) DUF4221 PF13970.6 ETO29726.1 - 0.25 10.8 11.8 0.061 12.9 4.9 2.9 1 1 2 4 4 4 0 Domain of unknown function (DUF4221) WD40 PF00400.32 ETO29727.1 - 4.3e-36 122.3 34.7 4.4e-07 30.5 3.2 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29727.1 - 7.7e-13 48.6 2.4 0.012 15.9 0.0 5.5 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29727.1 - 4.5e-08 32.2 9.5 0.03 13.0 0.1 5.0 1 1 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29727.1 - 0.00014 21.3 8.3 0.028 13.7 1.1 4.0 2 2 1 3 3 3 2 WD40-like domain Ribosomal_S25 PF03297.15 ETO29729.1 - 0.16 12.2 0.1 0.16 12.2 0.1 1.8 2 0 0 2 2 2 0 S25 ribosomal protein BRO1 PF03097.18 ETO29730.1 - 2.1e-18 66.3 3.5 2.6e-18 66.0 3.5 1.0 1 0 0 1 1 1 1 BRO1-like domain DUF1413 PF07205.11 ETO29731.1 - 0.053 13.5 0.6 0.13 12.3 0.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1413) SAPS PF04499.15 ETO29732.1 - 0.24 10.2 9.4 0.27 10.0 9.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO29732.1 - 0.4 8.9 9.0 0.37 9.0 9.0 1.0 1 0 0 1 1 1 0 CDC45-like protein NOA36 PF06524.12 ETO29732.1 - 0.55 9.5 15.8 0.64 9.3 15.8 1.1 1 0 0 1 1 1 0 NOA36 protein Zip PF02535.22 ETO29732.1 - 0.81 8.8 3.3 0.86 8.8 3.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO29732.1 - 1.2 7.8 5.5 1.4 7.6 5.5 1.0 1 0 0 1 1 1 0 Presenilin DUF4834 PF16118.5 ETO29732.1 - 1.9 9.5 7.4 4.6 8.3 7.4 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) NPR3 PF03666.13 ETO29732.1 - 2.2 7.0 7.8 2 7.1 7.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF2076 PF09849.9 ETO29732.1 - 2.6 8.0 17.4 3.1 7.8 17.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DNA_pol_phi PF04931.13 ETO29732.1 - 5.1 5.1 11.4 5.5 5.0 11.4 1.1 1 0 0 1 1 1 0 DNA polymerase phi FtsJ PF01728.19 ETO29733.1 - 5.4e-07 29.9 0.0 1.6e-06 28.4 0.0 1.9 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_25 PF13649.6 ETO29733.1 - 0.078 13.7 0.1 2.3 9.0 0.0 2.9 2 1 1 3 3 3 0 Methyltransferase domain Cnd1_N PF12922.7 ETO29735.1 - 0.0094 15.8 1.0 0.62 9.9 0.2 2.2 2 0 0 2 2 2 2 non-SMC mitotic condensation complex subunit 1, N-term DUF4834 PF16118.5 ETO29735.1 - 1.1 10.2 7.3 13 6.9 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Apc15p PF05841.11 ETO29735.1 - 7.2 7.4 14.4 2.8 8.8 7.1 2.3 2 0 0 2 2 2 0 Apc15p protein Roughex PF06020.11 ETO29736.1 - 0.26 10.3 7.8 0.35 9.9 7.8 1.1 1 0 0 1 1 1 0 Drosophila roughex protein YwiC PF14256.6 ETO29736.1 - 0.44 10.9 7.0 0.6 10.4 7.0 1.2 1 0 0 1 1 1 0 YwiC-like protein DUF334 PF03904.13 ETO29737.1 - 0.0044 16.6 8.5 0.0046 16.5 8.5 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF334) Ribosomal_L21p PF00829.21 ETO29738.1 - 1.6e-13 50.7 0.3 2e-13 50.5 0.3 1.1 1 0 0 1 1 1 1 Ribosomal prokaryotic L21 protein RSRP PF17069.5 ETO29739.1 - 0.009 15.6 21.5 0.009 15.6 21.5 2.5 3 0 0 3 3 3 1 Arginine/Serine-Rich protein 1 OST-HTH PF12872.7 ETO29739.1 - 0.015 15.1 0.3 0.033 14.0 0.3 1.6 1 0 0 1 1 1 0 OST-HTH/LOTUS domain zf_CCCH_4 PF18345.1 ETO29739.1 - 1.5 8.9 4.2 5.2 7.3 0.1 3.2 3 0 0 3 3 3 0 Zinc finger domain ShK PF01549.24 ETO29739.1 - 4.1 8.0 6.9 8.6 7.0 1.4 2.5 1 1 1 2 2 2 0 ShK domain-like SNARE PF05739.19 ETO29740.1 - 1.2e-10 41.3 5.4 1.4e-10 41.0 0.8 2.7 1 1 1 2 2 2 1 SNARE domain PDZ_3 PF17815.1 ETO29740.1 - 0.043 13.7 1.0 0.072 12.9 1.0 1.4 1 0 0 1 1 1 0 PDZ domain G-alpha PF00503.20 ETO29741.1 - 2.5e-56 191.4 8.7 1.6e-47 162.4 6.9 2.0 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO29741.1 - 2.9e-05 23.6 0.8 0.0052 16.3 0.1 2.4 2 0 0 2 2 2 2 ADP-ribosylation factor family MRP-S32 PF10210.9 ETO29741.1 - 0.003 18.1 3.7 2.8 8.6 0.5 3.3 3 0 0 3 3 3 2 Mitochondrial 28S ribosomal protein S32 Erv26 PF04148.13 ETO29741.1 - 0.011 15.5 0.2 0.021 14.6 0.2 1.3 1 0 0 1 1 1 0 Transmembrane adaptor Erv26 MMR_HSR1 PF01926.23 ETO29741.1 - 0.015 15.4 0.1 0.26 11.4 0.1 2.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO29741.1 - 0.045 13.1 2.5 1.1 8.6 0.2 2.5 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region AAA_29 PF13555.6 ETO29741.1 - 0.093 12.5 0.0 0.29 10.9 0.0 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain LisH_2 PF16045.5 ETO29742.1 - 1.1e-07 30.8 0.2 1.1e-07 30.8 0.2 1.7 2 0 0 2 2 2 1 LisH UPF0242 PF06785.11 ETO29742.1 - 0.0046 17.1 12.4 0.0046 17.1 12.4 2.4 1 1 1 2 2 2 1 Uncharacterised protein family (UPF0242) N-terminus FOP_dimer PF09398.10 ETO29742.1 - 0.0084 16.3 0.5 0.03 14.6 0.0 2.3 2 0 0 2 2 2 1 FOP N terminal dimerisation domain Csm1_N PF18504.1 ETO29742.1 - 0.01 16.2 7.2 0.01 16.2 7.2 3.4 2 1 2 4 4 4 0 Csm1 N-terminal domain SHE3 PF17078.5 ETO29742.1 - 0.064 13.0 21.7 0.74 9.5 21.8 2.4 1 1 0 1 1 1 0 SWI5-dependent HO expression protein 3 DUF4407 PF14362.6 ETO29742.1 - 0.075 12.4 13.6 0.19 11.1 13.6 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) APG6_N PF17675.1 ETO29742.1 - 0.21 12.1 19.6 0.84 10.2 14.1 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF4404 PF14357.6 ETO29742.1 - 0.49 11.1 14.1 1.5 9.5 3.5 3.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4404) GCN5L1 PF06320.13 ETO29742.1 - 0.54 10.4 14.3 0.27 11.4 4.9 2.9 2 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) DUF724 PF05266.14 ETO29742.1 - 1.1 9.0 23.4 0.043 13.6 11.2 2.7 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Spectrin PF00435.21 ETO29742.1 - 5 7.7 18.4 1.2 9.6 9.5 2.8 2 1 1 3 3 3 0 Spectrin repeat Fez1 PF06818.15 ETO29742.1 - 5 7.5 24.9 16 5.8 18.1 2.2 1 1 0 2 2 2 0 Fez1 DUF2570 PF10828.8 ETO29742.1 - 5.7 6.8 19.1 0.42 10.5 1.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2570) Acetyltransf_8 PF13523.6 ETO29743.1 - 0.0078 15.9 0.8 0.016 14.9 0.8 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain NRDE-2 PF08424.10 ETO29744.1 - 0.008 15.3 0.9 0.47 9.5 0.0 2.2 1 1 0 1 1 1 1 NRDE-2, necessary for RNA interference IFT81_CH PF18383.1 ETO29746.1 - 1.3e-14 54.5 0.1 1.5e-14 54.3 0.1 1.0 1 0 0 1 1 1 1 Intraflagellar transport 81 calponin homology domain DUF483 PF04467.12 ETO29746.1 - 0.023 14.7 0.0 0.03 14.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF483) Caudo_TAP PF02413.17 ETO29748.1 - 0.12 12.5 0.9 0.17 12.1 0.7 1.4 1 1 0 1 1 1 0 Caudovirales tail fibre assembly protein, lambda gpK Serinc PF03348.15 ETO29749.1 - 1.8 7.4 5.8 0.074 12.0 0.5 1.4 2 0 0 2 2 2 0 Serine incorporator (Serinc) TPR_12 PF13424.6 ETO29751.1 - 1e-78 259.6 16.8 1.2e-18 67.1 0.7 7.5 4 3 4 8 8 8 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29751.1 - 8.6e-63 205.8 52.2 6.3e-08 32.1 0.7 9.9 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29751.1 - 1.2e-58 193.5 5.8 1.8e-06 27.6 0.1 9.6 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29751.1 - 2.9e-56 183.4 20.6 4.2e-06 26.4 0.0 10.1 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 ETO29751.1 - 1.9e-49 161.8 50.8 5.3e-06 26.2 1.0 10.5 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29751.1 - 2.5e-49 161.4 37.3 2.8e-06 27.0 0.2 10.3 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_17 PF13431.6 ETO29751.1 - 4.7e-26 89.3 16.5 0.093 13.2 0.2 10.1 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO29751.1 - 1.3e-18 66.1 0.0 0.77 10.7 0.0 9.1 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO29751.1 - 2.1e-17 62.5 16.5 0.12 13.0 0.0 10.0 10 0 0 10 10 10 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO29751.1 - 2.5e-16 60.0 0.4 0.97 10.1 0.0 8.3 5 4 2 8 8 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29751.1 - 3.9e-14 52.0 45.7 0.065 12.9 0.0 12.5 10 2 3 13 13 13 8 TPR repeat TPR_MalT PF17874.1 ETO29751.1 - 1.1e-11 44.7 0.0 8.4e-06 25.4 0.0 3.2 2 1 1 3 3 3 3 MalT-like TPR region MIT PF04212.18 ETO29751.1 - 1.9e-08 34.2 31.9 2.5 8.3 0.1 10.1 6 1 4 10 10 10 2 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO29751.1 - 2.1e-08 34.3 24.9 0.016 15.4 1.5 6.7 1 1 5 7 7 7 5 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO29751.1 - 1.7e-07 31.6 8.0 0.67 10.5 0.5 6.3 4 3 2 6 6 6 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO29751.1 - 7.8e-07 29.0 38.0 0.15 12.1 0.1 8.2 9 0 0 9 9 8 4 Tetratricopeptide repeat DUF5113 PF17140.4 ETO29751.1 - 9.2e-07 28.8 27.8 2.3 8.0 0.1 9.0 7 2 2 9 9 9 1 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETO29751.1 - 0.00014 22.4 16.1 0.68 10.7 0.9 6.4 5 1 0 5 5 5 1 Sel1 repeat HTH_Bact PF18768.1 ETO29751.1 - 0.00079 19.0 12.6 3.5 7.3 0.0 7.6 6 1 1 7 7 7 1 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO29751.1 - 0.0014 18.7 9.3 2.7 8.0 0.0 5.1 2 2 4 6 6 6 2 Protein of unknown function (DUF627) RPN7 PF10602.9 ETO29751.1 - 0.0025 17.5 18.8 0.32 10.7 0.2 5.5 1 1 4 5 5 5 2 26S proteasome subunit RPN7 DUF5475 PF17569.2 ETO29751.1 - 0.0034 17.7 2.7 1.1 9.6 0.0 3.8 2 1 2 4 4 3 1 Family of unknown function (DUF5475) NRBF2_MIT PF17169.4 ETO29751.1 - 0.018 15.2 1.4 32 4.8 0.0 4.7 4 0 0 4 4 4 0 MIT domain of nuclear receptor-binding factor 2 DUF3856 PF12968.7 ETO29751.1 - 0.037 14.1 11.5 2.7 8.0 1.9 5.1 4 1 1 5 5 5 0 Domain of Unknown Function (DUF3856) SHNi-TPR PF10516.9 ETO29751.1 - 0.049 13.1 10.7 4.3 6.9 0.1 5.9 7 0 0 7 7 6 0 SHNi-TPR Glyoxalase PF00903.25 ETO29751.1 - 0.066 13.4 3.7 1.9 8.7 0.6 3.6 3 1 0 3 3 3 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily PPR PF01535.20 ETO29751.1 - 0.16 12.3 13.5 31 5.1 0.0 7.8 9 1 1 10 10 8 0 PPR repeat SPO22 PF08631.10 ETO29751.1 - 0.18 11.3 9.8 2.3 7.6 1.6 4.0 3 1 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like Prefoldin PF02996.17 ETO29751.1 - 0.47 10.4 5.9 15 5.5 0.2 3.9 2 2 1 3 3 3 0 Prefoldin subunit DUF3450 PF11932.8 ETO29751.1 - 0.68 9.2 3.2 35 3.6 0.1 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Gaa1 PF04114.14 ETO29752.1 - 0.0012 17.9 3.4 0.0014 17.8 3.4 1.2 1 0 0 1 1 1 1 Gaa1-like, GPI transamidase component Kinesin PF00225.23 ETO29753.1 - 1.6e-17 63.4 0.0 2.2e-17 63.0 0.0 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO29753.1 - 2.4e-14 53.5 0.1 3.5e-14 53.0 0.1 1.2 1 0 0 1 1 1 1 Microtubule binding RINT1_TIP1 PF04437.13 ETO29753.1 - 0.028 13.3 0.0 0.038 12.9 0.0 1.1 1 0 0 1 1 1 0 RINT-1 / TIP-1 family AAA_23 PF13476.6 ETO29753.1 - 0.36 11.3 3.1 0.9 10.0 0.2 2.0 2 0 0 2 2 2 0 AAA domain Guanylate_cyc PF00211.20 ETO29754.1 - 1.1e-41 142.5 0.0 1.9e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain E1-E2_ATPase PF00122.20 ETO29754.1 - 0.1 12.1 3.1 2.5 7.6 0.0 2.2 2 0 0 2 2 2 0 E1-E2 ATPase Hemocyanin_C PF03723.14 ETO29754.1 - 0.12 11.6 0.0 0.58 9.5 0.0 1.9 1 1 1 2 2 2 0 Hemocyanin, ig-like domain DUF5592 PF17332.2 ETO29754.1 - 0.65 10.6 8.9 1.2 9.7 3.7 2.7 2 1 0 2 2 2 0 Family of unknown function (DUF5592) Mre11_DNA_bind PF04152.14 ETO29756.1 - 1.1e-19 71.4 0.0 1.1e-19 71.4 0.0 2.4 2 1 0 2 2 2 1 Mre11 DNA-binding presumed domain Metallophos PF00149.28 ETO29756.1 - 5.3e-12 46.7 2.9 5.3e-12 46.7 2.9 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO29756.1 - 2.2e-08 34.5 0.0 1.1e-07 32.2 0.0 2.2 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase superfamily domain CDC27 PF09507.10 ETO29757.1 - 0.015 14.7 42.1 0.022 14.2 42.1 1.3 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 TFIIF_alpha PF05793.12 ETO29757.1 - 0.032 12.8 51.9 0.045 12.4 51.9 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Mitofilin PF09731.9 ETO29757.1 - 5.7 5.6 34.4 6.7 5.4 34.4 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein DUF5448 PF17526.2 ETO29758.1 - 0.03 14.5 0.2 0.066 13.4 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5448) DUF2542 PF10808.8 ETO29760.1 - 0.029 14.9 0.6 0.029 14.9 0.6 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2542) Activin_recp PF01064.23 ETO29760.1 - 1.1 10.4 4.7 2.2 9.5 0.5 2.5 2 1 0 2 2 2 0 Activin types I and II receptor domain Pantoate_ligase PF02569.15 ETO29761.1 - 2e-78 263.3 0.0 2.6e-78 262.9 0.0 1.1 1 0 0 1 1 1 1 Pantoate-beta-alanine ligase Pantoate_transf PF02548.15 ETO29761.1 - 4.9e-43 147.4 0.0 8.8e-43 146.5 0.0 1.4 1 0 0 1 1 1 1 Ketopantoate hydroxymethyltransferase FAD_syn PF06574.12 ETO29761.1 - 0.011 15.7 0.0 0.024 14.6 0.0 1.5 1 0 0 1 1 1 0 FAD synthetase DUF2620 PF10941.8 ETO29761.1 - 0.18 11.9 0.0 0.34 11.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF2620 Ldl_recept_a PF00057.18 ETO29762.1 - 5.7e-30 103.2 64.0 1.5e-08 34.7 9.7 4.7 4 0 0 4 4 4 4 Low-density lipoprotein receptor domain class A HYR PF02494.16 ETO29762.1 - 1.1e-05 25.6 0.3 2.7e-05 24.4 0.3 1.7 1 0 0 1 1 1 1 HYR domain Peptidase_M20 PF01546.28 ETO29763.1 - 5.7e-07 29.4 0.0 9.1e-07 28.8 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 G-alpha PF00503.20 ETO29764.1 - 3.2e-51 174.6 0.2 4e-51 174.3 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO29764.1 - 9.9e-05 21.9 0.0 0.00022 20.7 0.0 1.8 1 1 0 1 1 1 1 ADP-ribosylation factor family Peptidase_M20 PF01546.28 ETO29765.1 - 6.6e-17 61.9 0.0 9.8e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 M20_dimer PF07687.14 ETO29765.1 - 3.6e-08 33.3 0.0 1.6e-07 31.2 0.0 2.0 2 0 0 2 2 2 1 Peptidase dimerisation domain TPR_1 PF00515.28 ETO29766.1 - 1.8e-29 100.3 26.4 8e-07 28.6 4.5 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO29766.1 - 8e-28 96.6 2.8 3.3e-14 52.9 0.3 4.0 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29766.1 - 9.1e-26 87.9 19.6 6.2e-06 25.9 3.0 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29766.1 - 4.2e-22 76.5 6.1 0.00067 19.5 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO29766.1 - 5.7e-20 69.8 25.1 0.0015 18.6 0.3 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29766.1 - 3.4e-18 64.9 3.9 0.00014 21.6 0.6 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO29766.1 - 1.9e-11 43.7 0.0 0.21 12.5 0.0 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO29766.1 - 1.6e-10 40.9 8.7 0.0059 17.2 1.5 5.3 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO29766.1 - 3e-06 27.8 0.0 0.21 12.3 0.0 4.5 3 2 0 4 4 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO29766.1 - 0.00012 22.1 23.3 0.002 18.2 2.0 4.2 5 0 0 5 5 5 3 Fis1 C-terminal tetratricopeptide repeat SPO22 PF08631.10 ETO29766.1 - 0.0004 20.0 5.6 0.038 13.5 0.7 3.2 3 0 0 3 3 3 1 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETO29766.1 - 0.00055 20.0 13.7 0.55 10.3 0.1 4.9 4 1 1 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO29766.1 - 0.0015 19.0 3.9 1.5 9.4 0.0 3.5 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO29766.1 - 0.01 16.2 9.6 15 6.2 0.0 5.7 5 2 1 6 6 5 0 Tetratricopeptide repeat TPR_9 PF13371.6 ETO29766.1 - 0.12 12.5 0.0 42 4.4 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat BAR_3 PF16746.5 ETO29766.1 - 0.12 12.0 5.7 0.92 9.2 0.2 2.9 2 1 1 3 3 3 0 BAR domain of APPL family DUF5113 PF17140.4 ETO29766.1 - 0.22 11.3 9.3 6.4 6.6 1.3 4.0 3 2 1 4 4 4 0 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO29766.1 - 0.23 11.7 15.9 4.3 7.6 6.4 4.5 2 2 3 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 ETO29766.1 - 0.51 10.0 12.9 2.9 7.6 3.8 3.4 2 2 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) SHNi-TPR PF10516.9 ETO29766.1 - 0.9 9.0 3.5 27 4.3 0.2 3.5 4 0 0 4 4 4 0 SHNi-TPR TPR_3 PF07720.12 ETO29766.1 - 1.1 9.3 12.2 0.12 12.4 4.6 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO29766.1 - 1.7 8.4 20.0 7.6 6.3 1.7 5.5 4 2 2 6 6 6 0 TPR repeat Sel1 PF08238.12 ETO29766.1 - 8.2 7.3 7.1 7.7 7.4 0.3 3.8 4 0 0 4 4 4 0 Sel1 repeat PSP PF04046.16 ETO29769.1 - 2.9e-13 49.4 1.2 6.5e-13 48.3 1.2 1.6 1 0 0 1 1 1 1 PSP CAF1A PF12253.8 ETO29769.1 - 0.02 15.0 0.8 0.07 13.3 0.8 1.9 1 0 0 1 1 1 0 Chromatin assembly factor 1 subunit A EAP30 PF04157.16 ETO29770.1 - 8.8e-67 224.8 0.1 1.1e-66 224.6 0.1 1.0 1 0 0 1 1 1 1 EAP30/Vps36 family CCB2_CCB4 PF11152.8 ETO29770.1 - 0.0052 16.1 0.1 0.011 15.0 0.0 1.6 2 0 0 2 2 2 1 Cofactor assembly of complex C subunit B, CCB2/CCB4 TrmB PF01978.19 ETO29770.1 - 0.027 14.4 0.0 0.062 13.2 0.0 1.6 1 0 0 1 1 1 0 Sugar-specific transcriptional regulator TrmB Virul_Fac PF10139.9 ETO29771.1 - 0.1 10.8 0.0 0.13 10.4 0.0 1.1 1 0 0 1 1 1 0 Putative bacterial virulence factor F-box PF00646.33 ETO29771.1 - 0.26 11.2 2.4 4.3 7.3 0.2 2.5 2 0 0 2 2 2 0 F-box domain Pkinase PF00069.25 ETO29772.1 - 4e-17 62.4 0.0 1.8e-10 40.7 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29772.1 - 0.021 14.1 0.0 0.042 13.1 0.0 1.4 1 0 0 1 1 1 0 Protein tyrosine kinase BicD PF09730.9 ETO29773.1 - 0.078 11.4 3.3 1.2 7.4 0.3 2.1 2 0 0 2 2 2 0 Microtubule-associated protein Bicaudal-D Acyltransf_C PF16076.5 ETO29773.1 - 0.15 12.2 1.3 0.31 11.1 1.3 1.5 1 0 0 1 1 1 0 Acyltransferase C-terminus His_Phos_1 PF00300.22 ETO29774.1 - 1.2e-07 31.7 0.1 5.5e-07 29.5 0.1 1.9 1 1 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ComFB PF10719.9 ETO29775.1 - 0.045 13.9 1.4 0.086 13.0 0.0 1.9 2 0 0 2 2 2 0 Late competence development protein ComFB UPF0730 PF15827.5 ETO29776.1 - 0.074 12.8 0.1 0.17 11.6 0.1 1.6 1 0 0 1 1 1 0 UPF0730 unknown protein family Zip PF02535.22 ETO29777.1 - 1.1e-09 37.9 2.0 3.6e-09 36.3 2.4 1.5 1 1 0 1 1 1 1 ZIP Zinc transporter Myc_target_1 PF15179.6 ETO29777.1 - 0.00065 19.7 1.3 0.019 14.9 0.0 2.3 2 1 0 2 2 2 1 Myc target protein 1 DUF5383 PF17355.2 ETO29777.1 - 0.014 15.7 0.2 0.03 14.7 0.2 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5383) DUF4834 PF16118.5 ETO29778.1 - 0.0057 17.6 2.3 0.0057 17.6 2.3 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF4834) Zip PF02535.22 ETO29778.1 - 0.28 10.4 1.7 0.33 10.1 1.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Peroxin-13_N PF04088.13 ETO29778.1 - 0.3 11.4 0.7 0.86 9.9 0.1 2.0 2 0 0 2 2 2 0 Peroxin 13, N-terminal region HCO3_cotransp PF00955.21 ETO29778.1 - 0.44 9.3 1.1 0.53 9.0 0.6 1.3 1 1 0 1 1 1 0 HCO3- transporter family Presenilin PF01080.17 ETO29778.1 - 2.1 7.0 4.3 2.7 6.6 4.3 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO29779.1 - 1e-24 87.4 2.7 1.4e-11 44.1 0.3 3.1 1 1 1 2 2 2 2 Solute carrier family 12 DUF3333 PF11812.8 ETO29779.1 - 0.014 15.6 0.5 0.021 15.0 0.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3333) Strumpellin PF10266.9 ETO29780.1 - 7.9e-62 209.3 5.9 9.2e-62 209.1 5.9 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Strumpellin PF10266.9 ETO29781.1 - 3.1e-71 240.5 2.2 3.7e-71 240.2 2.2 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin Ribosomal_L1 PF00687.21 ETO29782.1 - 1.5e-34 119.5 1.7 1.9e-34 119.2 1.7 1.1 1 0 0 1 1 1 1 Ribosomal protein L1p/L10e family WD40 PF00400.32 ETO29784.1 - 5.6e-65 213.7 19.1 2.5e-09 37.6 0.0 8.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29784.1 - 2.4e-18 66.2 3.1 0.015 15.6 0.0 8.2 3 1 6 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29784.1 - 2.4e-10 39.9 6.1 0.51 9.2 0.0 7.3 3 1 6 9 9 9 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO29784.1 - 5e-10 39.6 0.2 0.0023 17.8 0.1 3.6 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO29784.1 - 1.6e-06 27.7 2.3 0.0074 15.7 0.0 4.7 2 2 5 7 7 7 4 WD40-like domain Nup160 PF11715.8 ETO29784.1 - 5.2e-06 25.4 1.6 0.25 10.0 0.0 4.4 1 1 2 4 4 4 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO29784.1 - 1.2e-05 24.0 1.0 0.25 9.8 0.0 3.4 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO29784.1 - 0.00012 21.9 1.8 3.4 7.7 0.0 5.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Kelch_4 PF13418.6 ETO29784.1 - 0.0045 17.0 0.1 0.097 12.7 0.1 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain MRJP PF03022.16 ETO29784.1 - 0.0046 16.4 0.0 0.016 14.6 0.0 1.9 1 0 0 1 1 1 1 Major royal jelly protein Nbs1_C PF08599.10 ETO29784.1 - 0.013 15.6 0.6 0.03 14.5 0.6 1.5 1 0 0 1 1 1 0 DNA damage repair protein Nbs1 Kelch_5 PF13854.6 ETO29784.1 - 0.021 14.8 3.8 2.2 8.4 0.0 4.6 5 1 0 5 5 5 0 Kelch motif PQQ_2 PF13360.6 ETO29784.1 - 0.034 13.7 0.4 0.3 10.6 0.2 2.6 1 1 1 2 2 2 0 PQQ-like domain DUF4763 PF15960.5 ETO29784.1 - 0.045 13.1 0.7 0.073 12.4 0.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4763) Nucleoporin_N PF08801.11 ETO29784.1 - 0.061 12.1 1.0 1.6 7.4 0.3 2.7 2 1 0 2 2 2 0 Nup133 N terminal like Kelch_1 PF01344.25 ETO29784.1 - 0.39 10.3 3.6 2 8.0 0.3 3.5 4 0 0 4 4 4 0 Kelch motif Proteasome_A_N PF10584.9 ETO29784.1 - 0.57 9.9 4.2 20 5.0 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Peptidase_C97 PF05903.14 ETO29788.1 - 0.028 14.2 0.0 0.049 13.5 0.0 1.3 1 0 0 1 1 1 0 PPPDE putative peptidase domain Phage_RpbA PF10789.9 ETO29788.1 - 0.084 13.0 0.4 1.2 9.2 0.0 2.2 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA PHO4 PF01384.20 ETO29789.1 - 1.4e-35 123.0 15.6 2e-35 122.4 15.6 1.3 1 0 0 1 1 1 1 Phosphate transporter family NB PF04159.13 ETO29789.1 - 0.22 11.6 1.2 1 9.4 0.1 2.6 3 0 0 3 3 3 0 NB glycoprotein DUF4407 PF14362.6 ETO29789.1 - 7.6 5.8 6.7 15 4.8 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) DUF2108 PF09881.9 ETO29789.1 - 7.8 6.6 11.0 0.62 10.1 3.9 2.7 3 0 0 3 3 3 0 Predicted membrane protein (DUF2108) PHO4 PF01384.20 ETO29790.1 - 9.5e-46 156.4 0.4 1.2e-45 156.1 0.4 1.0 1 0 0 1 1 1 1 Phosphate transporter family NAPRTase_C PF17956.1 ETO29791.1 - 3.7e-31 107.8 4.0 2e-17 63.6 1.0 2.4 1 1 1 2 2 2 2 Nicotinate phosphoribosyltransferase C-terminal domain NAPRTase PF04095.16 ETO29791.1 - 5.1e-09 36.1 0.0 7.1e-08 32.3 0.0 2.2 1 1 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) family NAPRTase_N PF17767.1 ETO29791.1 - 6.6e-09 36.2 0.1 2.2e-08 34.5 0.0 2.0 2 0 0 2 2 2 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain APAF1_C PF17908.1 ETO29791.1 - 0.03 14.3 0.0 0.064 13.3 0.0 1.5 1 0 0 1 1 1 0 APAF-1 helical domain DUF2183 PF09949.9 ETO29792.1 - 0.009 16.3 0.2 0.029 14.7 0.2 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2183) PI3K_1B_p101 PF10486.9 ETO29794.1 - 0.0012 16.7 12.3 0.0014 16.5 12.3 1.1 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit MCM3AP_GANP PF16769.5 ETO29794.1 - 0.7 8.1 18.1 0.86 7.8 18.1 1.2 1 0 0 1 1 1 0 MCM3AP domain of GANP Nop53 PF07767.11 ETO29794.1 - 2.6 7.4 48.5 0.054 12.9 41.2 1.7 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 ETO29794.1 - 5.1 5.3 26.0 7.7 4.7 26.0 1.3 1 0 0 1 1 1 0 CDC45-like protein FH2 PF02181.23 ETO29795.1 - 6.9e-28 97.8 7.7 5.7e-22 78.3 1.1 2.1 2 0 0 2 2 2 2 Formin Homology 2 Domain FlxA PF14282.6 ETO29795.1 - 0.036 14.0 3.1 0.1 12.6 2.8 1.8 2 0 0 2 2 2 0 FlxA-like protein Muted PF14942.6 ETO29795.1 - 0.06 13.7 3.9 0.14 12.5 3.9 1.6 1 0 0 1 1 1 0 Organelle biogenesis, Muted-like protein RIC3 PF15361.6 ETO29795.1 - 0.067 13.6 1.3 0.16 12.4 1.3 1.7 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Matrilin_ccoil PF10393.9 ETO29795.1 - 0.069 13.0 0.6 0.55 10.1 0.2 2.5 3 0 0 3 3 3 0 Trimeric coiled-coil oligomerisation domain of matrilin Ax_dynein_light PF10211.9 ETO29795.1 - 0.11 12.4 3.3 0.23 11.4 3.3 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain DUF4834 PF16118.5 ETO29795.1 - 3.4 8.7 7.4 17 6.4 7.4 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Frag1 PF10277.9 ETO29797.1 - 0.16 11.5 0.2 0.2 11.2 0.2 1.1 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family Mucin PF01456.17 ETO29797.1 - 0.37 10.8 1.5 0.73 9.8 0.1 2.0 2 0 0 2 2 2 0 Mucin-like glycoprotein Papilloma_E5 PF03025.14 ETO29797.1 - 1.3 9.3 9.7 1.8 8.8 9.7 1.1 1 0 0 1 1 1 0 Papillomavirus E5 SAM_2 PF07647.17 ETO29798.1 - 2.7e-05 24.2 0.0 5.8e-05 23.1 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO29798.1 - 0.00019 21.8 0.0 0.00032 21.1 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MAP7 PF05672.11 ETO29798.1 - 0.014 15.1 19.4 0.019 14.6 19.4 1.2 1 0 0 1 1 1 0 MAP7 (E-MAP-115) family Spt20 PF12090.8 ETO29798.1 - 0.3 10.7 8.2 0.37 10.4 8.2 1.2 1 0 0 1 1 1 0 Spt20 family Plasmodium_Vir PF05795.11 ETO29798.1 - 0.41 10.0 5.5 0.16 11.4 3.4 1.4 2 0 0 2 2 2 0 Plasmodium vivax Vir protein Presenilin PF01080.17 ETO29798.1 - 2.2 7.0 4.9 2.4 6.8 4.9 1.1 1 0 0 1 1 1 0 Presenilin zf-C3HC4_3 PF13920.6 ETO29799.1 - 4.4 7.3 12.7 1.4e+02 2.4 8.8 3.5 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Rsm1 PF08600.10 ETO29799.1 - 8.3 6.6 7.1 2.9 8.1 3.0 2.2 2 1 1 3 3 3 0 Rsm1-like Pkinase PF00069.25 ETO29800.1 - 1.3e-15 57.5 0.5 1.5e-14 54.0 0.2 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29800.1 - 1e-05 25.0 0.1 0.00021 20.6 0.1 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO29801.1 - 9e-14 51.5 0.0 1.3e-13 51.0 0.0 1.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29801.1 - 4.5e-05 22.9 0.0 0.0001 21.7 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase FixQ PF05545.11 ETO29801.1 - 3.1 7.8 12.0 0.63 10.1 4.8 3.2 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Ta0938 PF11494.8 ETO29803.1 - 0.045 14.0 0.1 0.12 12.6 0.0 1.7 2 0 0 2 2 2 0 Ta0938 Gln-synt_N PF03951.19 ETO29804.1 - 8.9e-11 41.4 0.0 1.5e-10 40.6 0.0 1.3 1 0 0 1 1 1 1 Glutamine synthetase, beta-Grasp domain MMS1_N PF10433.9 ETO29805.1 - 2.8e-07 29.6 0.1 4e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term DUF4834 PF16118.5 ETO29805.1 - 5.7 8.0 5.7 2 9.4 1.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Menin PF05053.13 ETO29806.1 - 0.026 12.9 12.5 0.033 12.6 12.5 1.1 1 0 0 1 1 1 0 Menin BUD22 PF09073.10 ETO29806.1 - 0.13 11.5 21.5 0.18 11.1 21.5 1.1 1 0 0 1 1 1 0 BUD22 SLC12 PF03522.15 ETO29806.1 - 0.36 9.8 10.9 0.48 9.4 10.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 GREB1 PF15782.5 ETO29806.1 - 0.83 6.7 8.7 1 6.4 8.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Presenilin PF01080.17 ETO29806.1 - 0.98 8.1 16.0 1.5 7.5 16.0 1.3 1 0 0 1 1 1 0 Presenilin CCSAP PF15748.5 ETO29806.1 - 4 7.5 17.3 7.8 6.6 17.3 1.4 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated GET2 PF08690.10 ETO29806.1 - 5.5 6.6 16.1 8 6.0 16.1 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Peptidase_S64 PF08192.11 ETO29806.1 - 9.4 4.6 13.6 13 4.1 13.6 1.1 1 0 0 1 1 1 0 Peptidase family S64 CENP-H PF05837.12 ETO29807.1 - 0.03 14.7 4.0 0.051 14.0 4.0 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) FOG_N PF15888.5 ETO29807.1 - 0.22 11.9 3.5 0.27 11.6 3.0 1.5 1 1 0 1 1 1 0 Folded gastrulation N-terminus NOA36 PF06524.12 ETO29807.1 - 1.9 7.8 6.0 2.3 7.4 6.0 1.1 1 0 0 1 1 1 0 NOA36 protein DUF3584 PF12128.8 ETO29809.1 - 7e-05 20.6 40.5 8.5e-05 20.3 40.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF4404 PF14357.6 ETO29809.1 - 0.023 15.3 2.2 0.023 15.3 2.2 4.6 2 1 4 6 6 6 0 Domain of unknown function (DUF4404) Baculo_PEP_C PF04513.12 ETO29809.1 - 3.3 7.7 10.6 2 8.5 1.7 2.8 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF3466 PF11949.8 ETO29810.1 - 0.0019 16.9 0.5 0.002 16.9 0.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3466) DUF285 PF03382.14 ETO29810.1 - 0.0098 15.6 0.4 0.014 15.2 0.4 1.2 1 0 0 1 1 1 1 Mycoplasma protein of unknown function, DUF285 FRG1 PF06229.12 ETO29810.1 - 0.025 14.3 0.7 0.041 13.6 0.7 1.3 1 0 0 1 1 1 0 FRG1-like domain Aldedh PF00171.22 ETO29811.1 - 3.3e-25 88.5 0.3 3.7e-25 88.4 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF3047 PF11249.8 ETO29811.1 - 0.0043 16.5 0.1 0.0045 16.4 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3047) Virulence_fact PF13769.6 ETO29811.1 - 0.075 13.3 1.0 0.14 12.4 1.0 1.5 1 1 0 1 1 1 0 Virulence factor Biotin_carb_C PF02785.19 ETO29811.1 - 0.11 12.6 0.1 0.16 12.1 0.1 1.2 1 0 0 1 1 1 0 Biotin carboxylase C-terminal domain FleQ PF06490.11 ETO29811.1 - 0.13 12.6 0.0 1.4 9.3 0.0 1.9 1 1 1 2 2 2 0 Flagellar regulatory protein FleQ Sda PF08970.10 ETO29811.1 - 1.2 8.9 4.1 32 4.4 0.2 3.1 2 1 1 3 3 3 0 Sporulation inhibitor A COX16 PF14138.6 ETO29812.1 - 0.046 14.2 0.1 0.085 13.4 0.1 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase assembly protein COX16 CDV3 PF15359.6 ETO29814.1 - 0.011 16.2 1.1 0.02 15.4 1.1 1.3 1 0 0 1 1 1 0 Carnitine deficiency-associated protein 3 FAM163 PF15069.6 ETO29814.1 - 0.049 14.1 1.9 0.071 13.5 1.9 1.2 1 0 0 1 1 1 0 FAM163 family ETRAMP PF09716.10 ETO29814.1 - 0.061 13.4 0.7 0.12 12.4 0.7 1.5 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) EI24 PF07264.11 ETO29814.1 - 0.3 11.3 2.9 0.41 10.9 2.9 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) B56 PF01603.20 ETO29815.1 - 2.5e-69 234.2 0.4 3.1e-69 233.9 0.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) B56 PF01603.20 ETO29816.1 - 4.2e-28 98.5 0.4 4.9e-28 98.2 0.4 1.1 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) PH_8 PF15409.6 ETO29816.1 - 0.038 14.3 0.3 2.8 8.3 0.0 2.6 2 1 0 2 2 2 0 Pleckstrin homology domain Rogdi_lz PF10259.9 ETO29816.1 - 0.064 12.7 0.0 0.11 11.9 0.0 1.3 1 1 0 1 1 1 0 Rogdi leucine zipper containing protein RNA_pol_Rpb1_R PF05001.13 ETO29816.1 - 0.81 10.2 11.3 1.1 9.7 1.3 2.5 2 0 0 2 2 2 0 RNA polymerase Rpb1 C-terminal repeat HEAT_2 PF13646.6 ETO29818.1 - 2.9e-36 123.7 14.2 5.2e-10 39.6 1.1 6.0 1 1 6 7 7 7 7 HEAT repeats Ank_4 PF13637.6 ETO29818.1 - 4e-14 52.8 0.5 9.9e-08 32.4 0.0 3.3 1 1 2 3 3 3 2 Ankyrin repeats (many copies) HEAT PF02985.22 ETO29818.1 - 1.4e-13 49.8 7.7 0.0036 17.4 0.1 10.1 10 0 0 10 10 10 1 HEAT repeat Cnd1 PF12717.7 ETO29818.1 - 6.1e-12 45.9 11.5 0.0024 18.0 0.1 5.7 2 1 2 5 5 5 4 non-SMC mitotic condensation complex subunit 1 DUF294 PF03445.13 ETO29818.1 - 2.2e-11 43.7 0.0 1.2e-08 34.9 0.0 3.6 3 0 0 3 3 3 1 Putative nucleotidyltransferase DUF294 Ank_2 PF12796.7 ETO29818.1 - 3e-10 40.6 0.1 3.5e-09 37.1 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO29818.1 - 4.8e-09 35.7 0.1 4.5e-05 23.5 0.0 4.9 4 0 0 4 4 4 1 Ankyrin repeat Ank_5 PF13857.6 ETO29818.1 - 7.2e-08 32.6 0.2 3.8e-07 30.3 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (many copies) RTP1_C1 PF10363.9 ETO29818.1 - 3e-05 24.1 0.4 0.43 10.8 0.1 4.8 1 1 4 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO29818.1 - 0.0011 19.4 12.2 5.4 8.0 0.0 6.3 6 1 0 6 6 5 2 PBS lyase HEAT-like repeat NIT PF08376.10 ETO29818.1 - 0.0039 17.7 0.0 0.011 16.2 0.0 1.7 1 0 0 1 1 1 1 Nitrate and nitrite sensing Ank PF00023.30 ETO29818.1 - 0.0083 16.5 0.2 0.059 13.8 0.0 2.7 2 0 0 2 2 1 1 Ankyrin repeat DUF3385 PF11865.8 ETO29818.1 - 0.0092 15.9 1.1 29 4.5 0.0 5.3 3 3 2 5 5 5 0 Domain of unknown function (DUF3385) HEAT_EZ PF13513.6 ETO29818.1 - 0.01 16.3 12.8 5.1 7.7 0.1 6.8 5 2 3 8 8 7 0 HEAT-like repeat NTP_transf_2 PF01909.23 ETO29818.1 - 0.034 14.4 0.1 0.6 10.4 0.0 3.2 2 0 0 2 2 2 0 Nucleotidyltransferase domain LRR_4 PF12799.7 ETO29818.1 - 8.4 7.0 11.3 5.3 7.6 0.2 4.9 5 0 0 5 5 5 0 Leucine Rich repeats (2 copies) UBX PF00789.20 ETO29820.1 - 2.6e-08 34.0 0.1 8.2e-08 32.3 0.0 1.9 1 1 1 2 2 2 1 UBX domain PdaC PF13739.6 ETO29820.1 - 0.035 15.1 4.5 0.061 14.3 4.5 1.3 1 0 0 1 1 1 0 Deacetylase PdaC HicB PF05534.12 ETO29820.1 - 0.042 13.7 0.1 0.13 12.1 0.1 1.8 1 0 0 1 1 1 0 HicB family ALMT PF11744.8 ETO29820.1 - 0.4 9.4 8.3 0.46 9.3 8.3 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.17 ETO29820.1 - 0.69 10.0 5.3 0.75 9.9 5.3 1.1 1 0 0 1 1 1 0 DDHD domain Folliculin PF11704.8 ETO29820.1 - 1 9.2 7.0 1.3 8.9 7.0 1.1 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport Presenilin PF01080.17 ETO29820.1 - 2.2 7.0 9.1 2.4 6.9 9.1 1.0 1 0 0 1 1 1 0 Presenilin SIT PF15330.6 ETO29821.1 - 0.018 15.4 0.0 0.044 14.2 0.0 1.6 1 0 0 1 1 1 0 SHP2-interacting transmembrane adaptor protein, SIT zf-RING_14 PF17978.1 ETO29821.1 - 1 9.8 8.9 0.71 10.3 0.6 2.4 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain FtsH_ext PF06480.15 ETO29821.1 - 4.2 7.8 8.6 8.3 6.8 0.1 3.0 2 2 0 2 2 2 0 FtsH Extracellular WD40 PF00400.32 ETO29823.1 - 2e-41 139.2 31.7 1.1e-06 29.3 0.3 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO29823.1 - 2.9e-15 55.9 5.8 0.0028 16.4 0.0 5.9 1 1 4 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO29823.1 - 1.3e-11 44.6 1.6 0.14 12.4 0.0 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO29823.1 - 4.9e-07 29.4 6.9 0.0048 16.3 0.3 4.4 2 2 2 4 4 4 3 WD40-like domain CN_hydrolase PF00795.22 ETO29824.1 - 2.4e-54 184.4 0.0 3e-54 184.1 0.0 1.1 1 0 0 1 1 1 1 Carbon-nitrogen hydrolase zf-RanBP PF00641.18 ETO29825.1 - 3.6e-08 32.6 23.1 0.00021 20.5 0.9 3.6 3 0 0 3 3 3 3 Zn-finger in Ran binding protein and others DZR PF12773.7 ETO29825.1 - 0.0018 18.3 4.7 0.0018 18.3 4.7 2.9 2 1 2 4 4 4 3 Double zinc ribbon UBA PF00627.31 ETO29825.1 - 0.0018 18.1 0.1 0.0038 17.1 0.1 1.5 1 0 0 1 1 1 1 UBA/TS-N domain Vps36-NZF-N PF16988.5 ETO29825.1 - 0.14 11.6 18.2 0.87 9.0 0.9 4.3 2 1 1 3 3 3 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Mpp10 PF04006.12 ETO29825.1 - 3.8 5.8 73.3 0.0052 15.3 34.8 3.2 3 0 0 3 3 3 0 Mpp10 protein Agenet PF05641.12 ETO29826.1 - 2.8e-05 24.5 0.1 3.6e-05 24.1 0.1 1.2 1 0 0 1 1 1 1 Agenet domain SH3_1 PF00018.28 ETO29826.1 - 0.036 13.7 0.5 0.44 10.2 0.1 2.0 1 1 1 2 2 2 0 SH3 domain Intein_splicing PF14890.6 ETO29826.1 - 0.14 12.1 0.1 0.17 11.8 0.1 1.1 1 0 0 1 1 1 0 Intein splicing domain PDZ_6 PF17820.1 ETO29827.1 - 6.3e-06 25.9 0.0 1.4e-05 24.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ETO29827.1 - 0.00023 21.4 0.0 0.00064 20.0 0.0 1.7 1 0 0 1 1 1 1 PDZ domain C2 PF00168.30 ETO29827.1 - 0.022 15.1 0.0 0.056 13.7 0.0 1.7 1 0 0 1 1 1 0 C2 domain PKD_channel PF08016.12 ETO29828.1 - 0.056 12.1 0.1 0.072 11.8 0.1 1.1 1 0 0 1 1 1 0 Polycystin cation channel GYF PF02213.16 ETO29829.1 - 5.5e-18 64.4 1.0 8.9e-18 63.7 0.3 1.7 1 1 0 1 1 1 1 GYF domain GYF_2 PF14237.6 ETO29829.1 - 0.016 15.0 0.3 0.027 14.3 0.2 1.5 1 1 0 1 1 1 0 GYF domain 2 TRAM_LAG1_CLN8 PF03798.16 ETO29829.1 - 0.1 12.3 0.1 0.13 11.9 0.1 1.1 1 0 0 1 1 1 0 TLC domain VPS9 PF02204.18 ETO29831.1 - 4.8e-14 52.4 0.0 6.5e-14 52.0 0.0 1.2 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain SAM_1 PF00536.30 ETO29832.1 - 1e-10 41.9 0.6 1.6e-10 41.3 0.6 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO29832.1 - 8.2e-09 35.5 0.4 1.2e-08 34.9 0.4 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF2839 PF10999.8 ETO29832.1 - 0.2 12.0 0.2 0.47 10.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2839) IBB PF01749.20 ETO29834.1 - 2.6e-07 31.0 1.3 6.1e-07 29.8 1.3 1.6 1 1 0 1 1 1 1 Importin beta binding domain Arm PF00514.23 ETO29834.1 - 0.00019 21.4 0.1 0.14 12.2 0.0 3.0 2 1 1 3 3 3 2 Armadillo/beta-catenin-like repeat Calici_MSP PF05752.11 ETO29835.1 - 0.082 12.7 1.7 0.13 12.1 1.2 1.6 1 1 0 1 1 1 0 Calicivirus minor structural protein PNP_UDP_1 PF01048.20 ETO29837.1 - 5.4e-18 65.1 0.0 8.5e-18 64.5 0.0 1.3 1 0 0 1 1 1 1 Phosphorylase superfamily Caudo_TAP PF02413.17 ETO29837.1 - 0.00066 19.8 1.3 0.12 12.5 0.1 2.5 1 1 1 2 2 2 2 Caudovirales tail fibre assembly protein, lambda gpK RGS PF00615.19 ETO29838.1 - 0.00031 21.0 0.1 0.0006 20.1 0.1 1.5 1 0 0 1 1 1 1 Regulator of G protein signaling domain Nop53 PF07767.11 ETO29838.1 - 0.02 14.3 20.9 0.026 14.0 20.9 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC27 PF09507.10 ETO29838.1 - 0.59 9.5 24.3 0.75 9.1 24.3 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 SID-1_RNA_chan PF13965.6 ETO29838.1 - 0.67 8.3 7.9 1 7.7 7.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PAP_assoc PF03828.19 ETO29842.1 - 1.1e-12 47.9 2.3 1.5e-12 47.5 1.4 1.6 2 0 0 2 2 2 1 Cid1 family poly A polymerase tRNA_NucTransf2 PF09249.11 ETO29842.1 - 0.024 14.9 0.1 0.036 14.3 0.1 1.4 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain zf-RING_2 PF13639.6 ETO29843.1 - 6.4e-13 48.8 3.0 6.4e-13 48.8 3.0 2.0 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO29843.1 - 1.6e-10 40.7 3.8 1.6e-10 40.7 3.8 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO29843.1 - 1.1e-09 37.9 0.5 1.1e-09 37.9 0.5 2.4 2 0 0 2 2 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ETO29843.1 - 8.2e-08 32.4 6.3 3.5e-07 30.4 6.3 2.1 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO29843.1 - 2.7e-07 30.3 3.3 2.7e-07 30.3 3.3 2.5 3 0 0 3 3 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO29843.1 - 3.4e-05 23.7 1.4 3.4e-05 23.7 1.4 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO29843.1 - 4.7e-05 23.3 0.8 4.7e-05 23.3 0.8 2.8 3 1 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO29843.1 - 8.7e-05 22.3 1.8 8.7e-05 22.3 1.8 3.0 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO29843.1 - 0.0001 22.3 1.5 0.00026 21.0 1.5 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO29843.1 - 0.00084 19.2 2.1 0.003 17.4 2.0 2.0 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 DUF4834 PF16118.5 ETO29843.1 - 0.033 15.2 8.6 1.9 9.5 0.0 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) FANCL_C PF11793.8 ETO29843.1 - 0.049 13.8 3.4 0.28 11.4 3.4 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain RINGv PF12906.7 ETO29843.1 - 0.069 13.3 1.7 0.27 11.4 1.7 2.1 1 1 0 1 1 1 0 RING-variant domain Pex24p PF06398.11 ETO29843.1 - 0.63 9.0 0.0 0.63 9.0 0.0 2.5 1 1 1 3 3 3 0 Integral peroxisomal membrane peroxin zf-C3H2C3 PF17122.5 ETO29843.1 - 0.65 10.1 14.4 1.8 8.7 2.5 3.2 3 0 0 3 3 3 0 Zinc-finger Zn_ribbon_17 PF17120.5 ETO29843.1 - 1.1 8.9 7.1 0.081 12.6 1.4 2.2 2 0 0 2 2 2 0 Zinc-ribbon, C4HC2 type Pox_Ag35 PF03286.14 ETO29843.1 - 4.5 7.0 14.5 5.2 6.8 3.6 2.3 2 0 0 2 2 2 0 Pox virus Ag35 surface protein PTCB-BRCT PF12738.7 ETO29844.1 - 3.1e-08 33.4 0.1 9e-08 32.0 0.0 1.8 2 0 0 2 2 2 1 twin BRCT domain BRCT PF00533.26 ETO29844.1 - 8.3e-07 29.3 0.9 2.3e-06 27.9 0.1 2.3 2 1 0 2 2 2 1 BRCA1 C Terminus (BRCT) domain LIG3_BRCT PF16759.5 ETO29844.1 - 2.4e-05 24.5 0.1 6.7e-05 23.1 0.1 1.7 1 0 0 1 1 1 1 DNA ligase 3 BRCT domain BRCT_2 PF16589.5 ETO29844.1 - 0.029 14.8 0.1 0.029 14.8 0.1 2.6 3 1 1 4 4 4 0 BRCT domain, a BRCA1 C-terminus domain RTT107_BRCT_5 PF16770.5 ETO29844.1 - 0.03 14.2 0.2 0.085 12.7 0.0 1.8 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain NIF PF03031.18 ETO29845.1 - 1.2e-12 47.8 0.1 2.2e-12 47.0 0.1 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase DUF2608 PF11019.8 ETO29845.1 - 0.091 12.2 0.1 0.15 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2608) zf-RING_2 PF13639.6 ETO29848.1 - 3.6e-13 49.6 7.5 5.5e-13 49.0 7.5 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO29848.1 - 2.6e-10 39.9 3.3 2.6e-10 39.9 3.3 1.6 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO29848.1 - 1.7e-08 34.2 6.8 2.8e-08 33.5 6.8 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO29848.1 - 2.4e-07 30.5 5.5 4.3e-07 29.7 5.5 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO29848.1 - 3.8e-07 30.3 8.5 4.4e-06 26.9 8.5 2.2 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETO29848.1 - 1.9e-06 27.7 4.3 2.9e-06 27.0 4.3 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO29848.1 - 3.4e-06 26.9 4.2 6.1e-06 26.1 4.2 1.4 1 0 0 1 1 1 1 zinc-RING finger domain Prok-RING_4 PF14447.6 ETO29848.1 - 0.00025 20.8 4.7 0.00049 19.9 4.7 1.5 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-ANAPC11 PF12861.7 ETO29848.1 - 0.0032 17.5 5.6 0.013 15.6 4.0 2.6 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger Zn_ribbon_17 PF17120.5 ETO29848.1 - 0.0054 16.3 3.9 0.012 15.2 3.9 1.6 1 1 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_UBOX PF13445.6 ETO29848.1 - 0.014 15.4 6.6 0.029 14.4 6.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger Dicty_REP PF05086.12 ETO29848.1 - 0.023 12.7 9.1 0.03 12.3 9.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein CNDH2_C PF16858.5 ETO29848.1 - 0.038 13.9 5.1 0.047 13.6 5.1 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term zinc_ribbon_16 PF17034.5 ETO29848.1 - 0.06 13.6 3.8 0.47 10.7 1.0 2.3 1 1 1 2 2 2 0 Zinc-ribbon like family Pox_Ag35 PF03286.14 ETO29848.1 - 0.094 12.5 8.6 0.13 12.0 8.6 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PPL5 PF18168.1 ETO29848.1 - 0.17 11.2 3.9 0.21 10.9 3.9 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF2722 PF10846.8 ETO29848.1 - 0.46 9.4 9.5 0.54 9.1 9.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) zf-RING_4 PF14570.6 ETO29848.1 - 0.47 10.3 4.5 1.3 8.9 4.5 1.7 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain RINGv PF12906.7 ETO29848.1 - 0.63 10.2 3.5 1.8 8.8 3.5 1.8 1 1 0 1 1 1 0 RING-variant domain FANCL_C PF11793.8 ETO29848.1 - 0.8 9.9 4.7 3 8.1 4.7 2.0 1 1 0 1 1 1 0 FANCL C-terminal domain SDA1 PF05285.12 ETO29848.1 - 1.4 8.3 12.3 1.9 7.8 12.3 1.2 1 0 0 1 1 1 0 SDA1 DUF2457 PF10446.9 ETO29848.1 - 1.4 8.0 18.3 2.3 7.2 18.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NPR3 PF03666.13 ETO29848.1 - 1.8 7.3 6.1 2.2 7.0 6.1 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3295 PF11702.8 ETO29848.1 - 2.5 7.4 11.9 3 7.1 11.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) NOA36 PF06524.12 ETO29848.1 - 3 7.1 16.0 4.8 6.4 16.0 1.4 1 0 0 1 1 1 0 NOA36 protein zf-RING-like PF08746.11 ETO29848.1 - 3.1 8.2 6.4 0.28 11.5 1.8 1.6 2 0 0 2 2 1 0 RING-like domain Osteopontin PF00865.18 ETO29848.1 - 3.4 7.1 21.0 4.5 6.7 21.0 1.1 1 0 0 1 1 1 0 Osteopontin Nop14 PF04147.12 ETO29848.1 - 4.3 5.4 11.5 5 5.2 11.5 1.0 1 0 0 1 1 1 0 Nop14-like family MPM1 PF17234.2 ETO29849.1 - 0.037 14.3 2.4 0.087 13.1 2.3 1.6 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Neisseria_TspB PF05616.13 ETO29849.1 - 3.4 6.0 11.4 0.82 8.1 8.2 1.5 2 0 0 2 2 2 0 Neisseria meningitidis TspB protein Trypan_PARP PF05887.11 ETO29849.1 - 9.2 6.2 11.2 0.63 10.0 5.1 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) Ost5 PF05251.12 ETO29851.1 - 8e-05 22.8 0.3 0.00016 21.8 0.3 1.5 1 0 0 1 1 1 1 Oligosaccharyltransferase subunit 5 O-antigen_lig PF13425.6 ETO29851.1 - 0.049 12.4 5.8 0.062 12.1 5.8 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Glucos_trans_II PF14264.6 ETO29851.1 - 0.066 12.6 0.3 0.098 12.0 0.3 1.2 1 0 0 1 1 1 0 Glucosyl transferase GtrII NYN PF01936.18 ETO29852.1 - 1.1e-06 29.1 1.2 2.4e-06 28.1 0.2 2.0 2 0 0 2 2 2 1 NYN domain BUD22 PF09073.10 ETO29854.1 - 4.4 6.5 28.9 2.5 7.4 20.1 2.1 2 0 0 2 2 2 0 BUD22 WD40 PF00400.32 ETO29855.1 - 2.5e-34 116.7 30.1 1.2e-06 29.1 0.4 7.5 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29855.1 - 5.5e-11 42.6 6.0 0.0099 16.2 0.0 4.9 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO29855.1 - 1.5e-09 37.1 13.6 0.0045 15.7 0.2 4.9 1 1 4 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO29855.1 - 0.00023 20.6 7.6 0.19 11.0 0.9 4.1 3 1 0 4 4 4 3 WD40-like domain Endotoxin_C PF03944.14 ETO29855.1 - 1.1 9.6 6.8 0.83 10.0 0.6 2.4 2 1 0 2 2 2 0 delta endotoxin Ank_4 PF13637.6 ETO29856.1 - 2.3e-05 24.8 0.5 9.2e-05 22.9 0.2 2.3 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO29856.1 - 3.7e-05 23.8 0.3 0.00098 19.4 0.0 3.4 4 0 0 4 4 4 1 Ankyrin repeat Ank_2 PF12796.7 ETO29856.1 - 5.1e-05 23.8 0.1 0.00054 20.5 0.1 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO29856.1 - 0.00015 22.0 0.1 0.00065 19.9 0.1 2.1 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO29856.1 - 0.03 14.8 0.0 0.13 12.8 0.0 2.2 1 0 0 1 1 1 0 Ankyrin repeat HTH_Tnp_1_2 PF13022.6 ETO29856.1 - 0.66 10.1 3.6 10 6.3 0.1 3.4 3 0 0 3 3 3 0 Helix-turn-helix of insertion element transposase Mis14 PF08641.12 ETO29857.1 - 0.02 15.2 0.5 0.029 14.7 0.5 1.2 1 0 0 1 1 1 0 Kinetochore protein Mis14 like SIR2 PF02146.17 ETO29858.1 - 4.1e-07 30.1 0.0 5.3e-07 29.7 0.0 1.3 1 0 0 1 1 1 1 Sir2 family NARP1 PF12569.8 ETO29858.1 - 0.04 12.8 1.3 0.054 12.4 1.3 1.1 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Glutaredoxin PF00462.24 ETO29858.1 - 0.17 12.2 1.6 0.6 10.4 0.5 2.2 2 0 0 2 2 2 0 Glutaredoxin MMPL PF03176.15 ETO29859.1 - 7.9e-61 205.8 7.0 2.1e-30 105.8 0.8 2.4 2 1 0 2 2 2 2 MMPL family ACR_tran PF00873.19 ETO29859.1 - 0.013 13.2 10.0 0.47 8.1 6.1 2.3 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family DUF3810 PF12725.7 ETO29859.1 - 0.053 12.9 0.2 0.053 12.9 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3810) HSP20 PF00011.21 ETO29860.1 - 4.2e-20 71.8 0.3 5.6e-20 71.4 0.3 1.2 1 0 0 1 1 1 1 Hsp20/alpha crystallin family ArsA_HSP20 PF17886.1 ETO29860.1 - 8.1e-09 34.9 0.0 1.4e-08 34.1 0.0 1.4 1 1 0 1 1 1 1 HSP20-like domain found in ArsA hNIFK_binding PF12196.8 ETO29861.1 - 0.053 13.0 0.9 0.12 11.8 0.9 1.6 1 0 0 1 1 1 0 FHA Ki67 binding domain of hNIFK Flagellin_IN PF07196.13 ETO29861.1 - 0.056 13.6 0.0 0.089 13.0 0.0 1.3 1 0 0 1 1 1 0 Flagellin hook IN motif Skp1 PF01466.19 ETO29862.1 - 5.1 7.3 12.4 0.78 9.9 6.4 2.4 2 1 0 2 2 2 0 Skp1 family, dimerisation domain WD40 PF00400.32 ETO29863.1 - 1.2e-103 336.1 52.4 1e-07 32.5 0.2 15.6 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29863.1 - 3.7e-15 56.0 19.0 1.3 9.4 0.1 11.1 1 1 12 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO29863.1 - 2.5e-10 40.5 0.0 5.5e-10 39.4 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO29863.1 - 6.7e-05 22.4 2.0 0.00024 20.7 2.0 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO29863.1 - 0.00045 20.8 0.0 0.0027 18.2 0.0 2.5 1 0 0 1 1 1 1 AAA domain Str_synth PF03088.16 ETO29863.1 - 0.00093 19.3 0.3 9.8 6.4 0.0 5.2 3 1 2 5 5 5 1 Strictosidine synthase RNA_helicase PF00910.22 ETO29863.1 - 0.0014 19.0 0.7 0.22 11.9 0.0 4.1 3 0 0 3 3 3 1 RNA helicase AAA_22 PF13401.6 ETO29863.1 - 0.0025 18.1 0.0 0.015 15.6 0.0 2.4 1 0 0 1 1 1 1 AAA domain RsgA_GTPase PF03193.16 ETO29863.1 - 0.015 15.2 0.2 0.13 12.1 0.0 2.7 3 0 0 3 3 3 0 RsgA GTPase Pentapeptide_4 PF13599.6 ETO29863.1 - 0.03 14.5 1.4 0.14 12.3 1.4 2.3 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) ABC_tran PF00005.27 ETO29863.1 - 0.037 14.6 1.2 4.5 7.8 0.0 4.0 3 0 0 3 3 3 0 ABC transporter DUF2808 PF10989.8 ETO29863.1 - 0.16 12.0 4.7 0.053 13.5 0.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2808) Ras PF00071.22 ETO29864.1 - 8.3e-06 25.5 0.4 2.5e-05 23.9 0.4 1.9 1 1 0 1 1 1 1 Ras family F-box PF00646.33 ETO29864.1 - 0.00019 21.2 1.5 0.00043 20.1 1.5 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO29864.1 - 0.002 18.0 1.1 0.0041 17.0 1.1 1.5 1 0 0 1 1 1 1 F-box-like Ras PF00071.22 ETO29865.1 - 2.9e-07 30.2 0.0 4.1e-07 29.7 0.0 1.2 1 0 0 1 1 1 1 Ras family DUF3694 PF12473.8 ETO29866.1 - 0.09 13.4 0.0 0.18 12.5 0.0 1.5 1 1 0 1 1 1 0 Kinesin protein Zip PF02535.22 ETO29868.1 - 0.012 14.9 2.3 0.016 14.4 2.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO29868.1 - 0.018 16.0 3.1 0.11 13.5 1.8 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) DUF3341 PF11821.8 ETO29868.1 - 0.043 13.5 0.0 0.068 12.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) MLANA PF14991.6 ETO29868.1 - 7 7.0 6.3 0.89 9.9 0.2 2.5 2 1 1 3 3 3 0 Protein melan-A Methyltransf_21 PF05050.12 ETO29869.1 - 1.6e-08 34.8 0.1 2.9e-08 33.9 0.1 1.5 1 1 0 1 1 1 1 Methyltransferase FkbM domain DUF3810 PF12725.7 ETO29869.1 - 0.015 14.7 0.1 0.023 14.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3810) P2X_receptor PF00864.19 ETO29870.1 - 8.1e-64 216.0 0.9 3.6e-63 213.9 0.9 1.9 1 1 0 1 1 1 1 ATP P2X receptor 2OG-FeII_Oxy_3 PF13640.6 ETO29871.1 - 2.2e-10 41.3 0.5 3.6e-10 40.6 0.5 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Pox_C4_C10 PF03336.13 ETO29871.1 - 4.6e-06 26.0 0.0 2.1e-05 23.8 0.0 1.8 2 0 0 2 2 2 1 Poxvirus C4/C10 protein DUF5074 PF16819.5 ETO29872.1 - 0.13 12.3 3.4 0.28 11.3 1.0 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF5074) HIT PF01230.23 ETO29873.1 - 0.0037 18.0 0.2 0.1 13.4 0.0 2.4 2 0 0 2 2 2 1 HIT domain PRK PF00485.18 ETO29874.1 - 2.3e-09 37.3 0.1 1.2e-05 25.1 0.0 2.2 1 1 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family AAA_18 PF13238.6 ETO29874.1 - 0.00032 21.3 0.0 0.00055 20.5 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_17 PF13207.6 ETO29874.1 - 0.0013 19.2 0.3 0.015 15.7 0.3 2.2 1 1 0 1 1 1 1 AAA domain T2SSE PF00437.20 ETO29874.1 - 0.065 12.3 0.1 0.11 11.5 0.1 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein AAA_14 PF13173.6 ETO29874.1 - 0.088 12.8 0.0 0.19 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA domain DUF5300 PF17224.3 ETO29874.1 - 0.14 12.4 0.1 0.24 11.7 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5300) AAA_16 PF13191.6 ETO29874.1 - 0.15 12.5 0.0 0.21 12.0 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Mad3_BUB1_I PF08311.12 ETO29875.1 - 8.7e-33 112.9 8.5 1.4e-32 112.3 8.4 1.4 1 1 0 1 1 1 1 Mad3/BUB1 homology region 1 VPS28 PF03997.12 ETO29875.1 - 0.1 12.3 5.2 0.024 14.3 1.8 1.7 2 0 0 2 2 2 0 VPS28 protein DUF262 PF03235.14 ETO29875.1 - 0.12 12.5 5.8 0.22 11.7 5.8 1.5 1 0 0 1 1 1 0 Protein of unknown function DUF262 UvrD-helicase PF00580.21 ETO29875.1 - 2.2 7.7 9.6 4.2 6.8 9.6 1.6 1 1 0 1 1 1 0 UvrD/REP helicase N-terminal domain COG2 PF06148.11 ETO29875.1 - 5.9 7.0 8.4 0.27 11.3 0.4 2.5 2 1 1 3 3 3 0 COG (conserved oligomeric Golgi) complex component, COG2 Pox_Ag35 PF03286.14 ETO29876.1 - 0.58 9.9 38.8 0.022 14.5 7.0 3.3 3 0 0 3 3 3 0 Pox virus Ag35 surface protein Prothymosin PF03247.14 ETO29876.1 - 1.9 9.0 72.4 2.3 8.7 18.3 3.4 3 0 0 3 3 3 0 Prothymosin/parathymosin family BUD22 PF09073.10 ETO29876.1 - 2 7.7 44.2 0.59 9.4 26.2 2.2 2 0 0 2 2 2 0 BUD22 Pinin_SDK_memA PF04696.13 ETO29876.1 - 5 7.2 38.5 0.48 10.5 12.9 2.3 2 0 0 2 2 2 0 pinin/SDK/memA/ protein conserved region DUF4763 PF15960.5 ETO29876.1 - 7.4 5.8 27.7 4.1 6.6 10.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4763) Ndc1_Nup PF09531.10 ETO29876.1 - 9.3 4.8 5.5 14 4.2 5.5 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-RanBP PF00641.18 ETO29877.1 - 2.9e-05 23.3 5.0 7.2e-05 22.0 5.0 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Peptidase_S49 PF01343.18 ETO29878.1 - 3.5e-19 69.3 0.0 6.4e-19 68.4 0.0 1.4 1 0 0 1 1 1 1 Peptidase family S49 FKS1_dom1 PF14288.6 ETO29878.1 - 0.0038 17.5 0.2 0.01 16.2 0.0 1.8 2 0 0 2 2 2 1 1,3-beta-glucan synthase subunit FKS1, domain-1 DUF5531 PF17671.1 ETO29878.1 - 0.053 13.4 0.4 1.6 8.6 0.1 2.2 1 1 1 2 2 2 0 Family of unknown function (DUF5531) Saf_2TM PF18303.1 ETO29880.1 - 0.33 10.6 3.2 0.18 11.4 1.4 1.4 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain MatC_N PF07158.11 ETO29880.1 - 0.37 10.8 8.2 0.73 9.9 8.2 1.7 1 1 0 1 1 1 0 Dicarboxylate carrier protein MatC N-terminus DUF872 PF05915.12 ETO29880.1 - 2.8 8.1 5.9 7.6 6.7 0.0 2.7 1 1 2 3 3 3 0 Eukaryotic protein of unknown function (DUF872) DUF3439 PF11921.8 ETO29882.1 - 0.0036 17.2 6.4 0.095 12.7 1.0 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF3439) TFIIA PF03153.13 ETO29882.1 - 0.0043 17.1 14.5 0.0054 16.8 14.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit DUF305 PF03713.13 ETO29882.1 - 0.021 14.9 0.1 0.021 14.9 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF305) Mucin PF01456.17 ETO29882.1 - 0.38 10.7 28.3 0.62 10.1 15.7 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein OPA3 PF07047.12 ETO29882.1 - 7.5 6.3 12.4 6.9 6.5 0.3 2.7 2 1 0 2 2 2 0 Optic atrophy 3 protein (OPA3) WD40 PF00400.32 ETO29883.1 - 1.3e-11 44.8 1.2 4.6e-05 24.1 0.3 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO29883.1 - 0.002 16.8 0.1 0.014 14.1 0.1 1.8 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO29883.1 - 0.0049 17.1 0.0 3.6 8.0 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO29883.1 - 0.045 12.5 1.8 0.062 12.0 1.8 1.2 1 0 0 1 1 1 0 Nup133 N terminal like Imm57 PF15596.6 ETO29884.1 - 0.03 14.6 1.9 0.036 14.4 0.3 1.8 2 0 0 2 2 2 0 Immunity protein 57 DUF1077 PF06417.12 ETO29884.1 - 0.19 11.8 3.3 0.22 11.6 2.7 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1077) DUF4703 PF15775.5 ETO29884.1 - 0.22 11.3 0.4 0.51 10.1 0.3 1.6 1 1 1 2 2 2 0 Domain of unknown function (DUF4703) Kelch_1 PF01344.25 ETO29886.1 - 0.018 14.6 0.4 1.3 8.7 0.0 3.0 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO29886.1 - 0.045 14.1 2.9 1.9 8.9 0.0 3.6 4 0 0 4 4 4 0 Kelch motif NUDIX PF00293.28 ETO29890.1 - 2.1e-07 31.0 0.0 3.7e-06 27.0 0.0 2.4 2 0 0 2 2 2 1 NUDIX domain PTS_2-RNA PF01885.16 ETO29890.1 - 0.0032 17.5 0.0 0.0061 16.6 0.0 1.4 1 0 0 1 1 1 1 RNA 2'-phosphotransferase, Tpt1 / KptA family TMEM154 PF15102.6 ETO29890.1 - 0.013 15.4 0.9 0.013 15.4 0.9 1.9 3 0 0 3 3 3 0 TMEM154 protein family RasGEF PF00617.19 ETO29890.1 - 0.015 15.5 0.0 0.052 13.8 0.0 2.0 1 0 0 1 1 1 0 RasGEF domain zf-TRAF PF02176.18 ETO29892.1 - 1.4e-05 25.7 3.3 1.4e-05 25.7 3.3 2.8 3 0 0 3 3 3 1 TRAF-type zinc finger AvrM_N PF18247.1 ETO29892.1 - 0.25 11.3 7.6 2.1 8.3 0.2 2.6 1 1 1 2 2 2 0 Flax-rust effector AvrM N-terminal domain Exonuc_VII_L PF02601.15 ETO29892.1 - 0.39 10.2 5.7 0.45 10.0 5.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF334 PF03904.13 ETO29892.1 - 3.1 7.3 15.0 32 4.0 14.2 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF334) DUF730 PF05325.11 ETO29892.1 - 5.6 7.0 9.6 14 5.8 1.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF730) zf-C6H2 PF15801.5 ETO29892.1 - 6.1 7.2 11.4 3.2 8.1 2.6 3.5 3 1 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding DUF1664 PF07889.12 ETO29892.1 - 6.2 6.9 10.5 1.3 9.1 6.6 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) CDC45 PF02724.14 ETO29893.1 - 0.00012 20.6 17.0 0.00016 20.2 17.0 1.2 1 0 0 1 1 1 1 CDC45-like protein SDA1 PF05285.12 ETO29893.1 - 0.00023 20.7 23.2 0.00039 20.0 23.2 1.3 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO29893.1 - 0.0011 17.3 26.4 0.0015 16.9 26.4 1.1 1 0 0 1 1 1 1 Nop14-like family SpoIIP PF07454.11 ETO29893.1 - 0.0026 17.3 9.2 0.0048 16.4 9.2 1.5 1 0 0 1 1 1 1 Stage II sporulation protein P (SpoIIP) PTPRCAP PF15713.5 ETO29893.1 - 0.0026 18.1 25.6 0.0054 17.0 25.6 1.5 1 0 0 1 1 1 1 Protein tyrosine phosphatase receptor type C-associated PPP4R2 PF09184.11 ETO29893.1 - 0.017 14.7 22.1 0.04 13.5 22.1 1.6 1 0 0 1 1 1 0 PPP4R2 DDHD PF02862.17 ETO29893.1 - 0.019 15.1 1.5 0.034 14.3 1.5 1.5 1 0 0 1 1 1 0 DDHD domain PPL5 PF18168.1 ETO29893.1 - 0.024 14.0 9.9 0.045 13.1 9.9 1.4 1 0 0 1 1 1 0 Prim-pol family 5 DUF2457 PF10446.9 ETO29893.1 - 0.038 13.1 31.8 0.063 12.4 31.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) O-antigen_lig PF13425.6 ETO29893.1 - 0.05 12.4 4.1 0.084 11.6 4.1 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Paf1 PF03985.13 ETO29893.1 - 0.053 12.5 33.5 0.089 11.8 33.5 1.3 1 0 0 1 1 1 0 Paf1 Dynamin_N PF00350.23 ETO29893.1 - 0.062 13.4 2.2 0.14 12.2 2.2 1.7 1 0 0 1 1 1 0 Dynamin family CLN3 PF02487.17 ETO29893.1 - 0.071 12.2 3.5 0.14 11.2 3.5 1.4 1 0 0 1 1 1 0 CLN3 protein Hid1 PF12722.7 ETO29893.1 - 0.32 9.1 9.9 0.41 8.7 9.9 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NPR3 PF03666.13 ETO29893.1 - 0.36 9.6 11.8 0.62 8.8 11.8 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF4820 PF16091.5 ETO29893.1 - 0.49 9.7 13.3 0.86 8.9 13.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Pox_Ag35 PF03286.14 ETO29893.1 - 0.53 10.0 23.0 0.05 13.4 17.5 2.1 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Serinc PF03348.15 ETO29893.1 - 0.63 8.9 4.9 0.99 8.3 4.9 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) CPSF100_C PF13299.6 ETO29893.1 - 0.63 10.2 14.1 2 8.6 14.1 1.8 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal SLC12 PF03522.15 ETO29893.1 - 0.66 8.9 7.6 1 8.3 7.6 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Presenilin PF01080.17 ETO29893.1 - 0.82 8.4 14.3 1.3 7.7 14.3 1.2 1 0 0 1 1 1 0 Presenilin RR_TM4-6 PF06459.12 ETO29893.1 - 1.1 9.0 22.2 0.13 12.0 18.1 1.5 2 0 0 2 2 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO29893.1 - 1.2 8.2 7.8 1.8 7.7 7.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 ETO29893.1 - 1.2 8.8 10.3 2.5 7.8 10.3 1.5 1 0 0 1 1 1 0 Connexin zf-HIT PF04438.16 ETO29893.1 - 1.5 8.8 5.6 3.1 7.7 5.6 1.6 1 0 0 1 1 1 0 HIT zinc finger CSRNP_N PF16019.5 ETO29893.1 - 1.9 8.4 7.8 3.5 7.5 7.8 1.4 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF913 PF06025.12 ETO29893.1 - 2.4 7.0 10.8 4 6.3 10.8 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF4045 PF13254.6 ETO29893.1 - 2.6 7.6 11.9 4.1 6.9 11.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) ALMT PF11744.8 ETO29893.1 - 2.9 6.6 7.7 4.8 5.9 7.7 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter RAB3GAP2_C PF14656.6 ETO29893.1 - 5.9 5.0 7.0 9.6 4.3 7.0 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus STAC2_u1 PF16664.5 ETO29893.1 - 6 7.3 13.5 15 6.0 13.5 1.7 1 0 0 1 1 1 0 Unstructured on SH3 and cysteine-rich domain-containing protein 2 Neur_chan_memb PF02932.16 ETO29893.1 - 6.2 6.8 5.4 4.8 7.2 3.7 1.6 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region RP-C_C PF11800.8 ETO29893.1 - 7.8 6.5 8.8 14 5.8 8.8 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Usp PF00582.26 ETO29893.1 - 9 6.8 9.4 16 6.0 9.4 1.4 1 0 0 1 1 1 0 Universal stress protein family CobT PF06213.12 ETO29893.1 - 9.4 5.5 38.1 15 4.9 38.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF5523 PF17661.1 ETO29893.1 - 9.6 5.8 30.2 19 4.8 30.2 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5523) MDM10 PF12519.8 ETO29893.1 - 9.8 4.9 8.8 14 4.4 8.8 1.3 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 VIT1 PF01988.19 ETO29894.1 - 1.8 8.4 2.8 7.7 6.3 2.7 2.1 1 1 0 1 1 1 0 VIT family RsdA_SigD_bd PF16751.5 ETO29895.1 - 0.13 12.5 0.0 0.22 11.8 0.0 1.3 1 0 0 1 1 1 0 Anti-sigma-D factor RsdA to sigma factor binding region DUF3545 PF12065.8 ETO29896.1 - 0.0021 18.0 3.4 0.0032 17.4 0.1 2.8 2 0 0 2 2 2 1 Protein of unknown function (DUF3545) HU-DNA_bdg PF14848.6 ETO29896.1 - 0.033 14.2 2.8 0.064 13.3 0.0 2.9 3 0 0 3 3 3 0 DNA-binding domain DivIC PF04977.15 ETO29896.1 - 0.1 12.4 0.1 0.1 12.4 0.1 5.6 5 2 1 6 6 6 0 Septum formation initiator Nudix_N PF12535.8 ETO29896.1 - 0.11 12.2 5.8 2.5 7.8 0.2 3.8 3 1 0 3 3 3 0 Hydrolase of X-linked nucleoside diphosphate N terminal HALZ PF02183.18 ETO29896.1 - 0.21 11.8 0.1 0.21 11.8 0.1 4.9 5 0 0 5 5 5 0 Homeobox associated leucine zipper Pre-PUA PF17832.1 ETO29896.1 - 3.5 8.4 7.1 5.6 7.7 0.3 2.9 3 1 0 3 3 3 0 Pre-PUA-like domain TT1725 PF18324.1 ETO29896.1 - 4.1 7.6 8.3 2.8 8.1 1.0 3.4 3 1 0 3 3 3 0 Hypothetical protein TT1725 Herpes_BLRF2 PF05812.12 ETO29896.1 - 6.1 7.0 14.5 0.55 10.4 0.9 3.6 4 1 0 4 4 4 0 Herpesvirus BLRF2 protein DUF3199 PF11436.8 ETO29897.1 - 0.0008 19.4 0.1 0.002 18.2 0.1 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF3199) OmpH PF03938.14 ETO29897.1 - 0.025 14.9 6.0 0.025 14.9 6.0 3.6 2 1 0 2 2 2 0 Outer membrane protein (OmpH-like) HD_assoc PF13286.6 ETO29897.1 - 9.6 6.8 12.9 0.69 10.5 0.1 3.0 4 0 0 4 4 4 0 Phosphohydrolase-associated domain WD40 PF00400.32 ETO29898.1 - 3.1e-35 119.6 23.5 3.3e-07 30.9 0.8 6.4 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO29898.1 - 1e-07 31.1 0.7 0.093 11.4 0.0 4.3 3 2 0 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO29898.1 - 7.1e-06 26.2 0.0 0.027 14.8 0.0 4.0 4 0 0 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO29898.1 - 0.033 12.9 3.3 1.1 7.9 0.2 3.3 2 1 2 4 4 4 0 Nup133 N terminal like Adaptin_N PF01602.20 ETO29899.1 - 1.5e-34 119.5 0.6 2e-34 119.0 0.6 1.0 1 0 0 1 1 1 1 Adaptin N terminal region HEAT PF02985.22 ETO29899.1 - 0.0038 17.4 3.3 0.92 9.9 0.1 4.9 6 0 0 6 6 6 1 HEAT repeat HEAT_2 PF13646.6 ETO29899.1 - 0.13 12.7 3.1 0.58 10.6 0.1 3.3 3 3 1 4 4 4 0 HEAT repeats CtsR_C PF17727.1 ETO29899.1 - 0.19 11.9 2.5 3.9 7.7 0.1 2.7 2 0 0 2 2 2 0 CtsR C-terminal dimerization domain Dicty_REP PF05086.12 ETO29901.1 - 0.0024 16.0 0.9 0.0029 15.7 0.9 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein Mucin PF01456.17 ETO29901.1 - 3.7 7.5 8.9 4.7 7.2 3.4 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein Rap_GAP PF02145.15 ETO29902.1 - 7.9e-15 54.9 1.1 1.2e-13 51.0 0.1 2.8 2 1 0 2 2 2 1 Rap/ran-GAP SRP-alpha_N PF04086.13 ETO29903.1 - 0.92 9.4 32.4 1.2 9.1 32.4 1.1 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal Dsh_C PF12316.8 ETO29903.1 - 1.7 9.0 21.8 2.2 8.6 21.8 1.2 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal RR_TM4-6 PF06459.12 ETO29903.1 - 4.7 7.0 21.1 6.1 6.6 21.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO29903.1 - 7.8 4.6 22.0 9.5 4.4 22.0 1.2 1 0 0 1 1 1 0 CDC45-like protein CK_II_beta PF01214.18 ETO29904.1 - 1.2e-29 103.4 0.0 2.4e-29 102.4 0.0 1.4 1 1 0 1 1 1 1 Casein kinase II regulatory subunit zf-TRAF PF02176.18 ETO29905.1 - 0.00061 20.4 3.9 0.00061 20.4 3.9 2.8 2 1 0 2 2 2 1 TRAF-type zinc finger FAD_SOX PF18371.1 ETO29905.1 - 0.026 14.9 0.7 0.062 13.7 0.7 1.6 1 0 0 1 1 1 0 Flavin adenine dinucleotide (FAD)-dependent sulfhydryl oxidase Dynein_AAA_lid PF17852.1 ETO29905.1 - 0.31 11.1 4.3 0.085 12.9 0.6 2.0 2 1 1 3 3 3 0 Dynein heavy chain AAA lid domain Cyclin_C PF02984.19 ETO29907.1 - 3.6e-15 56.1 0.5 5e-15 55.6 0.5 1.2 1 0 0 1 1 1 1 Cyclin, C-terminal domain DSPc PF00782.20 ETO29908.1 - 0.0054 16.6 1.4 0.075 12.9 0.2 2.9 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain DUF2487 PF10673.9 ETO29908.1 - 0.072 13.1 0.5 0.42 10.6 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2487) Nop14 PF04147.12 ETO29909.1 - 0.0022 16.3 16.7 0.0027 16.0 16.7 1.2 1 0 0 1 1 1 1 Nop14-like family HSP70 PF00012.20 ETO29909.1 - 0.03 12.5 7.0 0.032 12.4 7.0 1.2 1 0 0 1 1 1 0 Hsp70 protein AAA_11 PF13086.6 ETO29909.1 - 0.67 9.7 8.7 1 9.1 8.7 1.3 1 0 0 1 1 1 0 AAA domain CWC25 PF12542.8 ETO29909.1 - 1 10.3 17.3 0.49 11.3 13.3 2.4 2 1 1 3 3 3 0 Pre-mRNA splicing factor Bud13 PF09736.9 ETO29909.1 - 1.4 9.3 22.2 0.56 10.6 18.3 2.1 2 1 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex Pox_Ag35 PF03286.14 ETO29909.1 - 2.8 7.7 15.1 5.3 6.8 15.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF2052 PF09747.9 ETO29909.1 - 2.9 8.0 27.0 0.67 10.0 23.1 1.8 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) CDC45 PF02724.14 ETO29909.1 - 5.9 5.1 17.1 9.3 4.4 17.1 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF740 PF05340.12 ETO29909.1 - 8.6 5.0 15.2 13 4.3 15.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF740) SLC12 PF03522.15 ETO29909.1 - 8.9 5.2 10.1 13 4.7 10.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 PA26 PF04636.13 ETO29909.1 - 9.3 5.0 10.7 13 4.6 10.7 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Sulfotransfer_1 PF00685.27 ETO29910.1 - 0.0022 17.5 0.1 0.0038 16.8 0.1 1.5 1 0 0 1 1 1 1 Sulfotransferase domain MIR PF02815.19 ETO29911.1 - 4.3e-11 43.0 1.6 1.9e-10 40.9 0.5 2.6 1 1 2 3 3 3 2 MIR domain DAGAT PF03982.13 ETO29912.1 - 0.012 14.6 2.1 0.016 14.2 0.9 1.6 2 0 0 2 2 2 0 Diacylglycerol acyltransferase DUF4834 PF16118.5 ETO29913.1 - 0.13 13.2 0.1 0.13 13.2 0.1 4.7 5 0 0 5 5 5 0 Domain of unknown function (DUF4834) ACI44 PF15270.6 ETO29913.1 - 4.9 7.4 7.4 0.37 11.0 0.7 2.7 4 0 0 4 4 4 0 Metallo-carboxypeptidase inhibitor Ribosomal_L6e PF01159.19 ETO29914.1 - 0.012 16.2 0.6 0.023 15.3 0.6 1.4 1 0 0 1 1 1 0 Ribosomal protein L6e Chordopox_A13L PF05961.11 ETO29914.1 - 0.097 12.9 0.3 1.5 9.1 0.0 2.5 2 1 0 2 2 2 0 Chordopoxvirus A13L protein Ctr PF04145.15 ETO29914.1 - 0.24 12.0 3.0 0.79 10.3 3.0 1.8 1 1 0 1 1 1 0 Ctr copper transporter family eIF3_p135 PF12807.7 ETO29914.1 - 0.29 11.1 5.1 1.2 9.2 0.2 2.1 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Pap_E4 PF02711.14 ETO29914.1 - 9.1 7.3 8.5 6.3 7.8 1.5 2.1 2 0 0 2 2 2 0 E4 protein UME PF08064.13 ETO29915.1 - 0.081 12.9 0.0 0.22 11.5 0.0 1.8 1 0 0 1 1 1 0 UME (NUC010) domain Arm PF00514.23 ETO29915.1 - 0.36 10.9 1.7 1.3 9.2 0.2 2.9 2 1 0 2 2 2 0 Armadillo/beta-catenin-like repeat TFIIF_alpha PF05793.12 ETO29916.1 - 0.024 13.2 38.8 0.027 13.1 38.8 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Nop14 PF04147.12 ETO29916.1 - 0.51 8.5 34.5 0.57 8.3 34.5 1.1 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO29916.1 - 3.5 6.9 40.4 4.7 6.5 40.4 1.2 1 0 0 1 1 1 0 SDA1 ALMT PF11744.8 ETO29916.1 - 4.6 6.0 6.4 5.2 5.8 6.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Ricin_B_lectin PF00652.22 ETO29917.1 - 4.4e-12 46.3 13.8 2.5e-07 31.0 3.3 2.4 1 1 1 2 2 2 2 Ricin-type beta-trefoil lectin domain GHD PF17834.1 ETO29917.1 - 1.3e-06 28.3 0.2 4.6e-06 26.6 0.2 2.0 1 0 0 1 1 1 1 Beta-sandwich domain in beta galactosidase BetaGal_dom4_5 PF13364.6 ETO29917.1 - 5.3e-06 27.0 7.0 0.026 15.1 0.2 3.1 3 0 0 3 3 3 2 Beta-galactosidase jelly roll domain NIF PF03031.18 ETO29918.1 - 5.1e-20 71.8 0.2 1.1e-14 54.5 0.0 2.7 2 0 0 2 2 2 2 NLI interacting factor-like phosphatase PTCB-BRCT PF12738.7 ETO29918.1 - 1.8e-07 31.0 0.0 4.6e-07 29.7 0.0 1.6 1 0 0 1 1 1 1 twin BRCT domain BRCT_2 PF16589.5 ETO29918.1 - 9.8e-07 29.1 0.0 2.9e-06 27.6 0.0 1.8 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETO29918.1 - 3.9e-06 27.2 0.1 1.4e-05 25.3 0.1 2.1 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain Peptidase_A8 PF01252.18 ETO29918.1 - 0.18 12.0 1.0 0.45 10.7 1.0 1.6 1 0 0 1 1 1 0 Signal peptidase (SPase) II Kin17_mid PF10357.9 ETO29918.1 - 0.2 11.6 3.7 3.7 7.5 0.0 3.0 2 0 0 2 2 2 0 Domain of Kin17 curved DNA-binding protein Biotin_lipoyl_2 PF13533.6 ETO29919.1 - 3.2e-06 26.9 0.0 6.7e-06 25.8 0.0 1.5 1 0 0 1 1 1 1 Biotin-lipoyl like Biotin_lipoyl PF00364.22 ETO29919.1 - 7e-05 22.6 0.1 0.00012 21.8 0.1 1.3 1 0 0 1 1 1 1 Biotin-requiring enzyme LolA PF03548.15 ETO29919.1 - 0.0063 16.2 0.4 0.012 15.3 0.4 1.5 1 0 0 1 1 1 1 Outer membrane lipoprotein carrier protein LolA AMA-1 PF02430.15 ETO29919.1 - 0.045 12.7 1.0 0.078 11.9 1.0 1.3 1 0 0 1 1 1 0 Apical membrane antigen 1 FliH PF02108.16 ETO29919.1 - 0.16 12.1 0.1 0.26 11.3 0.1 1.3 1 0 0 1 1 1 0 Flagellar assembly protein FliH DUF3255 PF11631.8 ETO29919.1 - 0.17 11.8 0.1 0.3 11.0 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3255) FlaG PF03646.15 ETO29920.1 - 0.095 12.9 1.8 0.16 12.2 1.8 1.3 1 0 0 1 1 1 0 FlaG protein DUF1722 PF08349.11 ETO29921.1 - 0.08 13.2 2.6 1 9.7 0.5 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1722) Herpes_gE PF02480.16 ETO29921.1 - 0.21 10.3 0.6 0.28 9.9 0.6 1.1 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E PP2C_C PF07830.13 ETO29921.1 - 1.2 9.6 6.8 1.8 9.1 0.0 2.7 2 0 0 2 2 2 0 Protein serine/threonine phosphatase 2C, C-terminal domain DUF740 PF05340.12 ETO29921.1 - 4.4 5.9 7.9 6.4 5.4 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF740) Orf78 PF06024.12 ETO29922.1 - 0.069 13.5 1.0 0.16 12.3 1.0 1.6 1 0 0 1 1 1 0 Orf78 (ac78) CBP4 PF07960.11 ETO29922.1 - 0.16 11.8 1.3 0.33 10.8 1.3 1.4 1 0 0 1 1 1 0 CBP4 Secretin_N_2 PF07655.13 ETO29922.1 - 1.7 9.3 10.0 4.1 8.0 10.0 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain IRK_C PF17655.1 ETO29924.1 - 1.8e-19 70.0 0.0 4.3e-19 68.8 0.0 1.6 1 0 0 1 1 1 1 Inward rectifier potassium channel C-terminal domain IRK PF01007.20 ETO29924.1 - 1.1e-05 25.2 4.6 5.8e-05 22.9 4.6 2.0 1 1 0 1 1 1 1 Inward rectifier potassium channel transmembrane domain Ion_trans_2 PF07885.16 ETO29924.1 - 1.2e-05 25.2 9.9 2.9e-05 23.9 9.9 1.7 1 0 0 1 1 1 1 Ion channel Ion_trans PF00520.31 ETO29924.1 - 0.044 13.0 7.2 0.096 11.9 7.2 1.5 1 0 0 1 1 1 0 Ion transport protein Pentapeptide PF00805.22 ETO29925.1 - 2.5e-70 231.5 52.5 1.3e-10 40.7 2.2 11.8 5 3 7 13 13 13 12 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO29925.1 - 2.2e-54 181.5 51.6 6.1e-14 51.9 6.2 7.3 1 1 3 6 6 6 6 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO29925.1 - 4.3e-34 116.4 48.9 1.6e-06 28.1 1.0 10.8 4 3 5 9 9 9 8 Pentapeptide repeats (9 copies) NPV_P10 PF05531.12 ETO29925.1 - 0.0013 19.1 1.1 0.0013 19.1 1.1 3.3 2 1 1 3 3 3 1 Nucleopolyhedrovirus P10 protein Tup_N PF08581.10 ETO29925.1 - 0.016 15.5 11.0 0.065 13.5 11.0 2.1 1 0 0 1 1 1 0 Tup N-terminal DUF3576 PF12100.8 ETO29925.1 - 0.075 13.2 0.1 0.64 10.1 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3576) Cas_DxTHG PF09455.10 ETO29925.1 - 0.14 11.7 9.9 0.25 10.9 9.9 1.5 1 0 0 1 1 1 0 CRISPR-associated (Cas) DxTHG family Scm3 PF10384.9 ETO29925.1 - 0.54 10.0 2.8 2.1 8.2 2.0 2.4 2 0 0 2 2 2 0 Centromere protein Scm3 FapA PF03961.13 ETO29925.1 - 1.1 7.8 10.7 2.4 6.7 10.7 1.6 1 0 0 1 1 1 0 Flagellar Assembly Protein A RRP36 PF06102.12 ETO29925.1 - 2.1 8.3 17.4 4.7 7.2 17.4 1.5 1 0 0 1 1 1 0 rRNA biogenesis protein RRP36 Exonuc_VII_L PF02601.15 ETO29925.1 - 2.5 7.6 14.4 0.26 10.8 8.9 2.1 2 0 0 2 2 2 0 Exonuclease VII, large subunit DivIC PF04977.15 ETO29925.1 - 4.4 7.2 14.1 3.3 7.5 3.5 2.8 1 1 1 2 2 2 0 Septum formation initiator TMPIT PF07851.13 ETO29925.1 - 7.4 5.7 20.7 0.58 9.4 10.5 3.1 3 0 0 3 3 3 0 TMPIT-like protein Cpn60_TCP1 PF00118.24 ETO29927.1 - 6.6e-43 147.1 0.1 7.7e-43 146.8 0.1 1.1 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 ETO29928.1 - 1e-84 284.9 1.2 1.3e-84 284.7 1.2 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Glucosamine_iso PF01182.20 ETO29929.1 - 6.6e-05 22.9 0.0 0.00016 21.6 0.0 1.7 1 1 0 1 1 1 1 Glucosamine-6-phosphate isomerases/6-phosphogluconolactonase TIR_3 PF18567.1 ETO29929.1 - 0.15 12.1 0.4 0.4 10.7 0.3 1.7 2 0 0 2 2 2 0 Toll/interleukin-1 receptor domain Tet_JBP PF12851.7 ETO29932.1 - 0.075 12.4 0.9 0.089 12.1 0.9 1.1 1 0 0 1 1 1 0 Oxygenase domain of the 2OGFeDO superfamily DOMON PF03351.17 ETO29935.1 - 0.00075 19.7 0.4 0.0013 18.9 0.4 1.4 1 0 0 1 1 1 1 DOMON domain PT PF04886.12 ETO29935.1 - 0.067 12.7 36.1 1.1 8.9 29.1 3.3 2 1 0 2 2 2 0 PT repeat DUF4106 PF13388.6 ETO29935.1 - 2.5 7.2 7.3 3.6 6.7 7.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4106) V-SNARE PF05008.15 ETO29936.1 - 1.3e-12 47.9 2.4 1.3e-12 47.9 2.4 2.4 2 1 0 2 2 2 1 Vesicle transport v-SNARE protein N-terminus V-SNARE_C PF12352.8 ETO29936.1 - 9.1e-10 38.7 3.5 9.1e-10 38.7 3.5 1.8 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus ZnuA PF01297.17 ETO29936.1 - 0.0012 18.3 0.3 0.0023 17.4 0.1 1.3 1 1 0 1 1 1 1 Zinc-uptake complex component A periplasmic Sec20 PF03908.13 ETO29936.1 - 0.01 15.7 0.8 0.03 14.2 0.1 2.1 2 0 0 2 2 2 0 Sec20 Prominin PF05478.11 ETO29936.1 - 0.23 9.4 4.8 1.1 7.1 0.2 2.1 1 1 1 2 2 2 0 Prominin TMPIT PF07851.13 ETO29936.1 - 0.37 10.0 10.9 1.1 8.5 2.2 2.2 1 1 1 2 2 2 0 TMPIT-like protein Jnk-SapK_ap_N PF09744.9 ETO29936.1 - 4.1 7.6 15.9 0.34 11.1 8.0 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF2207 PF09972.9 ETO29936.1 - 5.3 5.7 9.0 27 3.4 9.0 1.9 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Exonuc_VII_L PF02601.15 ETO29936.1 - 9.5 5.7 10.4 23 4.4 10.4 1.7 1 1 0 1 1 1 0 Exonuclease VII, large subunit EssA PF10661.9 ETO29938.1 - 0.017 14.9 1.1 0.057 13.3 1.1 1.9 1 0 0 1 1 1 0 WXG100 protein secretion system (Wss), protein EssA Shisa PF13908.6 ETO29938.1 - 0.06 13.6 0.8 0.3 11.3 0.4 2.2 2 1 0 2 2 2 0 Wnt and FGF inhibitory regulator DUF3112 PF11309.8 ETO29938.1 - 0.72 9.3 5.2 1.8 7.9 5.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) p450 PF00067.22 ETO29939.1 - 1.5e-31 109.6 0.0 2e-31 109.3 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 GET2 PF08690.10 ETO29940.1 - 0.0033 17.1 7.6 0.04 13.6 7.6 2.0 1 1 0 1 1 1 1 GET complex subunit GET2 Endonuc_Holl PF10107.9 ETO29940.1 - 0.14 12.0 0.1 0.14 12.0 0.1 1.9 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase BPL_N PF09825.9 ETO29940.1 - 0.2 10.7 2.3 0.27 10.3 2.3 1.1 1 0 0 1 1 1 0 Biotin-protein ligase, N terminal DUF5542 PF17696.1 ETO29940.1 - 0.21 11.7 0.0 0.21 11.7 0.0 2.3 3 0 0 3 3 3 0 Family of unknown function (DUF5542) ADH_zinc_N PF00107.26 ETO29941.1 - 1.3e-26 93.1 0.3 4.4e-26 91.4 0.1 1.9 2 1 0 2 2 2 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO29941.1 - 1.4e-07 32.6 0.0 2.2e-07 32.0 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase S6PP_C PF08472.10 ETO29941.1 - 0.0051 16.7 0.0 0.14 12.0 0.0 2.5 2 1 0 2 2 2 1 Sucrose-6-phosphate phosphohydrolase C-terminal ADH_N PF08240.12 ETO29942.1 - 2.5e-09 37.0 0.4 2e-08 34.1 0.0 2.1 2 0 0 2 2 2 1 Alcohol dehydrogenase GroES-like domain zf-RanBP PF00641.18 ETO29942.1 - 0.00019 20.6 7.9 0.00048 19.4 7.9 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Cytochrom_c3_2 PF14537.6 ETO29942.1 - 0.13 12.7 2.9 0.25 11.8 2.9 1.5 1 0 0 1 1 1 0 Cytochrome c3 YajC PF02699.15 ETO29943.1 - 0.19 11.7 1.4 0.58 10.1 1.4 1.9 1 0 0 1 1 1 0 Preprotein translocase subunit CENP-B_dimeris PF09026.10 ETO29943.1 - 2.6 8.5 16.1 4.7 7.7 7.2 2.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain WD40 PF00400.32 ETO29944.1 - 8.1e-51 168.9 9.1 1.7e-10 41.3 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29944.1 - 2.9e-18 66.0 0.1 9.5e-05 22.6 0.0 5.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29944.1 - 4.6e-10 39.0 0.0 0.021 13.8 0.0 5.0 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO29944.1 - 1.1e-08 34.8 3.4 0.12 12.4 0.0 5.6 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO29944.1 - 0.00048 20.2 0.1 21 5.2 0.0 4.2 2 1 2 4 4 4 0 Family of unknown function (DUF5570) SGL PF08450.12 ETO29944.1 - 0.00054 19.6 0.0 0.0078 15.8 0.0 2.6 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region WD40_like PF17005.5 ETO29944.1 - 0.0012 18.2 0.6 0.87 8.9 0.0 3.2 2 2 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 ETO29944.1 - 0.0024 16.6 2.5 0.19 10.3 0.0 3.5 2 2 2 4 4 4 1 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO29944.1 - 0.0032 16.6 0.0 0.35 9.9 0.0 2.4 1 1 1 2 2 2 2 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO29944.1 - 0.0078 14.8 0.1 0.99 7.9 0.0 2.9 2 1 1 3 3 3 1 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO29944.1 - 0.022 13.5 0.0 0.72 8.6 0.0 3.0 3 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Proteasome_A_N PF10584.9 ETO29944.1 - 0.065 12.9 6.1 38 4.1 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Nbas_N PF15492.6 ETO29944.1 - 0.076 12.3 0.1 0.65 9.3 0.0 2.4 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Kelch_6 PF13964.6 ETO29945.1 - 4.7e-06 26.7 2.3 0.0083 16.4 0.1 3.4 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO29945.1 - 0.00081 18.9 1.0 0.77 9.4 0.1 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO29945.1 - 0.0031 17.5 5.2 0.017 15.1 0.1 4.2 6 0 0 6 6 6 1 Kelch motif Kelch_3 PF13415.6 ETO29945.1 - 0.039 14.2 0.1 0.38 11.1 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO29945.1 - 0.12 12.4 3.5 4.8 7.3 0.1 3.5 3 0 0 3 3 3 0 Kelch motif ArsA_HSP20 PF17886.1 ETO29946.1 - 0.051 13.1 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 HSP20-like domain found in ArsA DUF3530 PF12048.8 ETO29946.1 - 0.067 12.6 0.3 0.098 12.1 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3530) TPR_12 PF13424.6 ETO29947.1 - 6e-23 80.9 0.3 1.7e-21 76.3 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO29947.1 - 2.9e-22 77.8 0.2 1.1e-08 34.6 0.1 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO29947.1 - 3.2e-17 61.2 2.7 4.1e-09 35.8 0.1 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO29947.1 - 7.3e-14 50.8 9.0 6.4e-07 29.1 0.6 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO29947.1 - 2.3e-11 43.0 6.3 1.5e-06 27.8 0.7 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO29947.1 - 5.6e-08 32.3 7.4 3.8e-05 23.5 0.2 4.2 3 1 1 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO29947.1 - 0.00022 21.7 1.5 0.073 13.7 0.1 3.2 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO29947.1 - 0.00038 20.6 1.2 0.48 10.9 0.1 3.0 2 1 0 2 2 2 2 Tetratricopeptide repeat PPR PF01535.20 ETO29947.1 - 0.001 19.2 0.1 0.66 10.4 0.0 3.2 3 0 0 3 3 3 1 PPR repeat TPR_14 PF13428.6 ETO29947.1 - 0.0013 19.3 0.0 1.8 9.6 0.0 2.9 2 1 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO29947.1 - 0.0022 17.8 2.5 0.49 10.2 0.3 2.5 2 1 0 2 2 2 2 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETO29947.1 - 0.004 16.6 0.3 0.0051 16.2 0.3 1.3 1 0 0 1 1 1 1 MalT-like TPR region TPR_16 PF13432.6 ETO29947.1 - 0.02 15.6 0.0 0.6 10.8 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETO29947.1 - 0.2 11.8 6.3 0.3 11.2 1.3 2.9 2 1 1 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO29947.1 - 1.7 8.4 13.0 0.86 9.3 0.6 3.8 3 2 2 5 5 5 0 TPR repeat TPR_3 PF07720.12 ETO29947.1 - 2.7 8.1 8.7 0.84 9.7 2.2 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat WBP-1 PF11669.8 ETO29948.1 - 0.4 11.3 14.6 0.044 14.4 3.4 2.7 1 1 1 2 2 2 0 WW domain-binding protein 1 DUF2207 PF09972.9 ETO29948.1 - 0.49 9.1 2.7 10 4.8 0.7 2.4 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) DUF1980 PF09323.10 ETO29948.1 - 0.74 9.7 3.6 1.5 8.7 3.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) MNNL PF07657.13 ETO29950.1 - 0.033 14.2 0.7 0.15 12.2 0.7 2.1 1 0 0 1 1 1 0 N terminus of Notch ligand DUF2673 PF10880.8 ETO29950.1 - 0.043 13.9 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2673) SUIM_assoc PF16619.5 ETO29951.1 - 0.1 12.7 11.6 0.28 11.3 11.6 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 Presenilin PF01080.17 ETO29951.1 - 2.8 6.6 7.3 4.3 6.0 7.3 1.2 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO29951.1 - 3 7.0 4.2 4.3 6.4 4.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DUF2967 PF11179.8 ETO29951.1 - 6.6 4.7 7.4 8.9 4.3 7.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2967) Saw1 PF11561.8 ETO29951.1 - 7.7 6.0 9.6 0.23 11.0 2.6 1.9 3 0 0 3 3 3 0 Single strand annealing-weakened 1 CCDC53 PF10152.9 ETO29952.1 - 3.8e-05 24.1 1.2 3.8e-05 24.1 1.2 2.1 2 0 0 2 2 2 1 Subunit CCDC53 of WASH complex UBA PF00627.31 ETO29953.1 - 0.00025 20.9 0.4 0.00056 19.8 0.4 1.6 1 0 0 1 1 1 1 UBA/TS-N domain PDZ_6 PF17820.1 ETO29953.1 - 0.00034 20.4 0.0 0.00068 19.4 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ETO29953.1 - 0.06 13.7 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 PDZ domain TERB2 PF15101.6 ETO29953.1 - 0.62 10.1 7.2 0.23 11.5 0.3 2.3 2 0 0 2 2 2 0 Telomere-associated protein TERB2 Tudor_4 PF18358.1 ETO29953.1 - 1.2 8.8 4.1 2.7 7.7 1.9 2.3 2 0 0 2 2 2 0 Histone methyltransferase Tudor domain JmjC PF02373.22 ETO29954.1 - 4.5e-07 30.3 0.1 4.5e-07 30.3 0.1 2.3 2 0 0 2 2 2 1 JmjC domain, hydroxylase Cupin_8 PF13621.6 ETO29954.1 - 0.00022 21.1 0.7 0.00035 20.4 0.7 1.3 1 0 0 1 1 1 1 Cupin-like domain DUF3858 PF12970.7 ETO29954.1 - 0.049 13.6 0.0 0.091 12.8 0.0 1.4 1 0 0 1 1 1 0 Domain of Unknown Function with PDB structure (DUF3858) ERAP1_C PF11838.8 ETO29955.1 - 6e-30 104.9 1.2 1.8e-29 103.3 1.2 1.6 1 1 0 1 1 1 1 ERAP1-like C-terminal domain Rax2 PF12768.7 ETO29955.1 - 0.0042 16.6 0.2 0.0082 15.6 0.2 1.5 1 0 0 1 1 1 1 Cortical protein marker for cell polarity Oxidored_q2 PF00420.24 ETO29955.1 - 0.01 15.4 0.1 0.023 14.3 0.1 1.6 1 0 0 1 1 1 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 4L DUF4577 PF15145.6 ETO29955.1 - 0.011 15.8 0.0 0.021 14.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4577) DUF1230 PF06799.11 ETO29955.1 - 0.011 15.8 0.2 0.04 14.0 0.0 2.0 2 0 0 2 2 2 0 Conserved in the green lineage and diatoms 27 LapA_dom PF06305.11 ETO29955.1 - 0.017 14.9 0.4 0.037 13.8 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain TMEM154 PF15102.6 ETO29955.1 - 0.067 13.1 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 TMEM154 protein family DUF1180 PF06679.12 ETO29955.1 - 0.2 12.1 0.0 0.28 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) PUB PF09409.10 ETO29956.1 - 4.1e-10 39.4 0.4 8.2e-10 38.5 0.4 1.4 1 0 0 1 1 1 1 PUB domain Ras PF00071.22 ETO29957.1 - 5.2e-52 175.7 1.3 1.3e-50 171.2 0.3 2.7 2 1 0 2 2 2 1 Ras family Roc PF08477.13 ETO29957.1 - 1.3e-27 96.3 0.1 5.7e-13 49.1 0.0 2.7 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO29957.1 - 1.9e-06 27.4 0.2 3.4e-05 23.4 0.2 2.1 1 1 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO29957.1 - 0.015 15.3 0.0 0.036 14.2 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO29957.1 - 0.065 13.1 0.0 1.5 8.7 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase HALZ PF02183.18 ETO29958.1 - 0.0013 18.9 4.1 0.0013 18.9 4.1 3.8 4 0 0 4 4 3 1 Homeobox associated leucine zipper Laminin_II PF06009.12 ETO29958.1 - 0.0015 18.5 3.3 0.0015 18.5 3.3 2.3 1 1 1 2 2 2 1 Laminin Domain II DUF3450 PF11932.8 ETO29958.1 - 0.0029 16.9 2.0 0.0029 16.9 2.0 2.1 1 1 1 2 2 2 1 Protein of unknown function (DUF3450) GCN5L1 PF06320.13 ETO29958.1 - 0.014 15.5 1.5 0.014 15.5 1.5 3.3 2 1 1 3 3 3 0 GCN5-like protein 1 (GCN5L1) COG2 PF06148.11 ETO29958.1 - 0.019 15.0 13.1 0.057 13.5 3.6 2.2 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 JIP_LZII PF16471.5 ETO29958.1 - 0.041 14.1 3.4 0.041 14.1 3.4 3.1 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II WXG100 PF06013.12 ETO29958.1 - 0.043 14.0 1.0 0.043 14.0 1.0 3.7 2 1 1 3 3 3 0 Proteins of 100 residues with WXG End3 PF12761.7 ETO29958.1 - 0.069 13.3 17.7 0.037 14.2 12.9 2.1 1 1 1 2 2 2 0 Actin cytoskeleton-regulatory complex protein END3 Herpes_UL51 PF04540.13 ETO29958.1 - 0.079 12.7 0.2 0.22 11.2 0.0 1.7 2 0 0 2 2 2 0 Herpesvirus UL51 protein ADPrib_exo_Tox PF03496.14 ETO29958.1 - 0.084 12.2 4.2 0.15 11.4 3.3 1.8 1 1 1 2 2 2 0 ADP-ribosyltransferase exoenzyme THOC7 PF05615.13 ETO29958.1 - 0.11 12.8 17.7 0.55 10.5 6.0 2.8 2 1 0 2 2 2 0 Tho complex subunit 7 Prominin PF05478.11 ETO29958.1 - 0.14 10.1 17.5 0.014 13.4 7.0 2.0 1 1 1 2 2 2 0 Prominin DUF724 PF05266.14 ETO29958.1 - 0.15 11.8 18.0 0.032 14.1 6.4 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) DUF4618 PF15397.6 ETO29958.1 - 0.17 11.3 22.7 0.22 10.9 22.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4618) GAS PF13851.6 ETO29958.1 - 0.24 10.7 24.0 0.051 12.9 7.1 2.6 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF1664 PF07889.12 ETO29958.1 - 0.41 10.7 13.1 0.31 11.1 4.1 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) DUF4477 PF14780.6 ETO29958.1 - 0.49 10.0 6.6 1.8 8.2 6.0 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4477) MCPsignal PF00015.21 ETO29958.1 - 0.52 10.1 6.5 0.077 12.8 2.7 1.6 2 0 0 2 2 2 0 Methyl-accepting chemotaxis protein (MCP) signalling domain FlaC_arch PF05377.11 ETO29958.1 - 0.54 10.7 12.5 3.5 8.1 0.4 4.0 3 2 1 4 4 4 0 Flagella accessory protein C (FlaC) MbeD_MobD PF04899.12 ETO29958.1 - 0.64 10.2 15.4 6.1 7.0 1.3 3.4 2 1 1 3 3 3 0 MbeD/MobD like FlxA PF14282.6 ETO29958.1 - 0.66 10.0 25.8 3.7 7.6 6.5 3.4 2 1 1 3 3 3 0 FlxA-like protein DUF4407 PF14362.6 ETO29958.1 - 0.74 9.1 14.7 0.62 9.4 2.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) Nmad5 PF18757.1 ETO29958.1 - 0.78 9.9 8.8 2 8.6 2.3 2.3 2 0 0 2 2 2 0 Nucleotide modification associated domain 5 NPV_P10 PF05531.12 ETO29958.1 - 0.97 9.9 15.6 9.3 6.8 1.2 3.7 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ZapB PF06005.12 ETO29958.1 - 1 9.8 26.5 0.2 12.1 9.5 3.4 2 1 1 3 3 3 0 Cell division protein ZapB DUF4665 PF15679.5 ETO29958.1 - 1.4 9.6 16.5 0.79 10.4 2.2 3.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4665) DASH_Dad4 PF08650.10 ETO29958.1 - 1.5 8.8 6.8 3.5 7.7 0.1 3.6 2 1 2 4 4 4 0 DASH complex subunit Dad4 Bacillus_HBL PF05791.11 ETO29958.1 - 2.2 8.1 18.2 5 6.9 14.0 2.1 1 1 1 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) Seryl_tRNA_N PF02403.22 ETO29958.1 - 2.2 8.6 17.3 15 5.9 5.2 3.3 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain Nsp1_C PF05064.13 ETO29958.1 - 2.3 8.0 19.0 7.2 6.4 5.8 3.3 2 1 1 3 3 3 0 Nsp1-like C-terminal region Prefoldin PF02996.17 ETO29958.1 - 2.5 8.0 19.1 0.15 12.0 4.1 3.8 3 2 0 3 3 3 0 Prefoldin subunit HSCB_C PF07743.13 ETO29958.1 - 3.3 8.3 14.3 9 6.9 3.8 3.0 2 1 0 2 2 2 0 HSCB C-terminal oligomerisation domain Snapin_Pallidin PF14712.6 ETO29958.1 - 3.3 8.2 22.1 2.1 8.8 1.1 3.2 2 1 1 3 3 3 0 Snapin/Pallidin DUF948 PF06103.11 ETO29958.1 - 4 7.8 14.5 7.7 6.9 4.4 3.3 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) KfrA_N PF11740.8 ETO29958.1 - 5.7 7.7 10.9 2.2 9.0 2.2 2.5 2 1 0 2 2 2 0 Plasmid replication region DNA-binding N-term Spc24 PF08286.11 ETO29958.1 - 5.8 7.2 20.5 0.17 12.1 7.1 3.1 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 LMBR1 PF04791.16 ETO29958.1 - 7.7 5.3 12.1 9.6 5.0 12.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein KCT2 PF17818.1 ETO29959.1 - 0.11 12.6 0.8 0.25 11.4 0.8 1.5 1 0 0 1 1 1 0 Keratinocyte-associated gene product Met_synt_B12 PF02965.17 ETO29960.1 - 7.4e-108 360.1 0.0 1.3e-107 359.4 0.0 1.4 1 0 0 1 1 1 1 Vitamin B12 dependent methionine synthase, activation domain Pterin_bind PF00809.22 ETO29960.1 - 1.5e-52 178.8 0.2 4.1e-52 177.3 0.1 1.8 2 0 0 2 2 2 1 Pterin binding enzyme B12-binding_2 PF02607.17 ETO29960.1 - 1.3e-23 83.2 0.0 3.9e-23 81.7 0.0 1.9 1 0 0 1 1 1 1 B12 binding domain S-methyl_trans PF02574.16 ETO29960.1 - 1.1e-21 77.8 0.0 2.3e-21 76.8 0.0 1.6 1 0 0 1 1 1 1 Homocysteine S-methyltransferase B12-binding PF02310.19 ETO29960.1 - 1.9e-15 56.9 0.0 2.9e-14 53.1 0.0 2.6 3 0 0 3 3 3 1 B12 binding domain Cupin_4 PF08007.12 ETO29962.1 - 8.5e-29 101.0 0.0 1.4e-28 100.3 0.0 1.3 1 0 0 1 1 1 1 Cupin superfamily protein CDC45 PF02724.14 ETO29963.1 - 0.11 10.8 4.7 0.11 10.8 4.7 1.1 1 0 0 1 1 1 0 CDC45-like protein SDA1 PF05285.12 ETO29963.1 - 0.13 11.7 6.9 0.13 11.7 6.9 1.2 1 0 0 1 1 1 0 SDA1 RNF220 PF15926.5 ETO29963.1 - 0.2 11.2 6.3 0.32 10.6 6.3 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 EBV-NA3 PF05009.12 ETO29963.1 - 3.3 7.2 5.8 6.2 6.3 5.8 1.5 1 0 0 1 1 1 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) PFU PF09070.11 ETO29964.1 - 0.031 14.5 0.0 0.094 13.0 0.0 1.8 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) WD40 PF00400.32 ETO29965.1 - 1.7e-05 25.5 0.0 3.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat WD40 PF00400.32 ETO29966.1 - 2.8e-31 107.1 7.9 1e-09 38.8 0.2 6.5 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29966.1 - 1.7e-14 53.9 2.2 0.00089 19.5 0.1 4.8 2 2 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO29966.1 - 5.8e-06 26.3 0.5 0.0081 16.1 0.1 3.0 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO29966.1 - 0.00015 21.6 0.0 1.5 8.9 0.0 3.3 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat LPG_synthase_TM PF03706.13 ETO29966.1 - 0.0032 17.1 0.1 0.0065 16.0 0.2 1.4 2 0 0 2 2 2 1 Lysylphosphatidylglycerol synthase TM region WD40_like PF17005.5 ETO29966.1 - 0.021 14.1 0.1 0.13 11.6 0.0 2.2 1 1 0 1 1 1 0 WD40-like domain TFIIIC_delta PF12657.7 ETO29966.1 - 0.14 12.0 0.0 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 Transcription factor IIIC subunit delta N-term CTP_transf_like PF01467.26 ETO29968.1 - 1.7e-05 25.0 0.7 0.00011 22.4 0.1 2.6 3 0 0 3 3 3 1 Cytidylyltransferase-like DUF3225 PF11533.8 ETO29968.1 - 0.11 12.2 0.1 7.7 6.3 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3225) GW PF13457.6 ETO29969.1 - 0.42 11.3 5.9 0.55 10.9 0.1 2.4 1 1 2 3 3 3 0 GW (Gly-Tryp) dipeptide domain CLIP1_ZNF PF16641.5 ETO29970.1 - 0.094 12.6 1.0 0.25 11.2 1.0 1.8 1 0 0 1 1 1 0 CLIP1 zinc knuckle UCH_1 PF13423.6 ETO29970.1 - 0.15 11.6 1.3 4.1 6.9 0.0 2.0 1 1 1 2 2 2 0 Ubiquitin carboxyl-terminal hydrolase Striatin PF08232.12 ETO29972.1 - 5.9 7.5 10.3 0.87 10.2 1.5 2.7 2 1 0 2 2 2 0 Striatin family WD40 PF00400.32 ETO29973.1 - 7.4e-60 197.5 16.9 1.4e-10 41.5 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO29973.1 - 7.9e-20 71.0 0.4 7.2e-05 23.0 0.0 6.1 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO29973.1 - 4.2e-17 62.1 1.5 3.4e-05 23.0 0.0 6.6 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO29973.1 - 3.6e-13 49.8 0.1 2.8e-05 24.1 0.0 3.8 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO29973.1 - 1.7e-08 34.1 12.7 0.012 15.5 0.1 6.5 7 0 0 7 7 6 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO29973.1 - 7.8e-08 32.0 0.0 0.00061 19.2 0.0 2.8 2 1 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO29973.1 - 3.3e-06 25.9 0.2 0.013 14.1 0.1 2.5 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO29973.1 - 0.0014 17.4 4.9 1.4 7.4 0.0 4.1 1 1 3 4 4 4 2 Nucleoporin Nup120/160 DUF1258 PF06869.12 ETO29973.1 - 0.0033 17.0 0.6 1.5 8.3 0.0 3.0 2 1 1 3 3 3 1 Protein of unknown function (DUF1258) Frtz PF11768.8 ETO29973.1 - 0.026 12.8 0.0 0.68 8.2 0.0 2.0 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz FLgD_tudor PF13861.6 ETO29973.1 - 0.032 14.5 0.1 46 4.3 0.0 3.9 4 1 0 4 4 4 0 FlgD Tudor-like domain PQQ PF01011.21 ETO29973.1 - 0.044 13.7 0.0 0.24 11.4 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat SBD PF17882.1 ETO29973.1 - 0.058 13.2 0.4 2.5 7.9 0.0 2.9 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain DUF2480 PF10652.9 ETO29973.1 - 0.06 13.3 0.1 12 5.8 0.1 3.1 2 1 1 3 3 3 0 Protein of unknown function (DUF2480) PQQ_2 PF13360.6 ETO29973.1 - 0.062 12.9 0.2 0.18 11.4 0.2 1.8 1 1 0 1 1 1 0 PQQ-like domain DUF4875 PF16175.5 ETO29973.1 - 0.085 13.0 1.7 18 5.5 0.0 3.8 3 2 2 5 5 5 0 Domain of unknown function (DUF4875) Proteasome_A_N PF10584.9 ETO29973.1 - 2.2 8.1 8.0 55 3.6 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Metallophos PF00149.28 ETO29974.1 - 1.4e-06 29.0 0.1 2.3e-06 28.3 0.0 1.4 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase PI3_PI4_kinase PF00454.27 ETO29976.1 - 3.6e-29 102.3 0.5 1.1e-15 58.1 0.3 2.6 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase Ras PF00071.22 ETO29978.1 - 2.9e-44 150.5 6.9 1.2e-31 109.5 0.2 2.1 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO29978.1 - 8.5e-19 67.9 4.9 2.9e-08 34.0 0.0 2.4 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO29978.1 - 9.2e-07 28.5 3.5 0.007 15.8 0.5 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO29978.1 - 0.00012 21.7 0.8 0.049 13.2 0.1 2.1 2 0 0 2 2 2 2 Elongation factor Tu GTP binding domain DUF3243 PF11588.8 ETO29979.1 - 0.032 14.5 1.3 15 6.0 0.0 4.1 3 2 1 5 5 5 0 Protein of unknown function (DUF3243) CYTL1 PF15153.6 ETO29979.1 - 0.19 11.7 1.3 4.1 7.4 0.3 2.7 2 0 0 2 2 2 0 Cytokine-like protein 1 UpxZ PF06603.11 ETO29979.1 - 0.87 9.9 5.5 11 6.3 0.7 2.8 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists DUF775 PF05603.12 ETO29980.1 - 0.039 13.5 4.6 0.075 12.6 4.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF775) MCD PF05292.11 ETO29980.1 - 0.1 12.2 2.0 0.19 11.3 0.6 1.9 2 0 0 2 2 2 0 Malonyl-CoA decarboxylase C-terminal domain Roughex PF06020.11 ETO29980.1 - 2.2 7.3 14.4 0.55 9.3 3.4 2.2 2 0 0 2 2 2 0 Drosophila roughex protein PH PF00169.29 ETO29980.1 - 4.6 7.8 10.6 0.26 11.8 0.7 3.1 3 0 0 3 3 3 0 PH domain PBP1_TM PF14812.6 ETO29980.1 - 5.1 7.5 10.8 13 6.2 10.8 1.7 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Pkinase PF00069.25 ETO29982.1 - 8.2e-19 68.0 0.6 1.5e-18 67.1 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29982.1 - 1.4e-05 24.6 0.0 2.2e-05 23.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO29983.1 - 6.9e-35 120.7 1.3 1.2e-34 119.9 1.3 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO29983.1 - 3e-19 69.3 0.8 5.5e-19 68.4 0.3 1.6 2 0 0 2 2 2 1 Protein tyrosine kinase PH PF00169.29 ETO29983.1 - 0.00032 21.2 0.1 0.00093 19.7 0.1 1.9 1 0 0 1 1 1 1 PH domain FTA2 PF13095.6 ETO29983.1 - 0.029 14.0 0.3 0.29 10.7 0.0 2.3 1 1 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 EF-hand_1 PF00036.32 ETO29983.1 - 0.13 11.8 0.0 0.3 10.8 0.0 1.6 1 0 0 1 1 1 0 EF hand TFIIS_C PF01096.18 ETO29983.1 - 0.18 11.7 0.2 0.18 11.7 0.2 2.0 2 0 0 2 2 2 0 Transcription factor S-II (TFIIS) Nudix_N_2 PF14803.6 ETO29983.1 - 0.21 11.5 2.0 0.28 11.1 0.1 2.2 2 0 0 2 2 2 0 Nudix N-terminal Ceramidase PF05875.12 ETO29984.1 - 2.3e-44 151.8 20.6 2.3e-44 151.8 20.6 2.3 1 1 1 2 2 2 1 Ceramidase PTPLA PF04387.14 ETO29984.1 - 0.014 15.1 0.2 0.014 15.1 0.2 2.9 3 1 0 3 3 3 0 Protein tyrosine phosphatase-like protein, PTPLA Orf78 PF06024.12 ETO29984.1 - 0.099 13.0 0.2 0.46 10.8 0.1 2.1 2 0 0 2 2 2 0 Orf78 (ac78) LAP1C PF05609.12 ETO29984.1 - 0.21 10.7 0.1 0.32 10.1 0.1 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RasGEF PF00617.19 ETO29985.1 - 3.9e-23 82.5 0.1 3.9e-23 82.5 0.1 2.1 3 0 0 3 3 3 1 RasGEF domain Bet_v_1 PF00407.19 ETO29985.1 - 0.17 11.8 2.9 1.9 8.4 0.7 2.2 2 0 0 2 2 2 0 Pathogenesis-related protein Bet v I family Radical_SAM_C PF16199.5 ETO29987.1 - 9.6e-20 70.4 0.6 2.5e-19 69.1 0.6 1.6 1 0 0 1 1 1 1 Radical_SAM C-terminal domain Radical_SAM PF04055.21 ETO29987.1 - 9.3e-18 65.2 0.2 2.7e-17 63.6 0.2 1.8 1 0 0 1 1 1 1 Radical SAM superfamily Acetyltransf_1 PF00583.25 ETO29987.1 - 4.6e-06 26.9 0.1 2.1e-05 24.7 0.0 2.1 2 0 0 2 2 2 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO29987.1 - 0.0012 18.8 0.0 0.003 17.5 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain TCTP PF00838.17 ETO29987.1 - 0.042 14.2 2.5 0.09 13.1 2.5 1.5 1 0 0 1 1 1 0 Translationally controlled tumour protein PSS PF03034.15 ETO29987.1 - 0.056 13.2 0.2 0.11 12.2 0.2 1.4 1 0 0 1 1 1 0 Phosphatidyl serine synthase GTP_EFTU_D2 PF03144.25 ETO29988.1 - 0.0013 19.1 0.1 0.003 17.9 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ETO29988.1 - 0.046 13.6 0.5 0.1 12.5 0.2 1.7 2 0 0 2 2 2 0 Elongation factor Tu domain 4 GTP_EFTU PF00009.27 ETO29989.1 - 1.9e-09 37.3 0.0 5.8e-09 35.8 0.0 1.8 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO29989.1 - 0.00091 19.3 0.2 0.0066 16.5 0.1 2.5 2 1 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 ETO29989.1 - 0.01 15.3 0.0 1.9 7.9 0.0 2.9 1 1 1 2 2 2 0 Signal recognition particle receptor beta subunit Roc PF08477.13 ETO29989.1 - 0.013 15.7 0.0 0.052 13.8 0.0 2.1 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase HTH_Bact PF18768.1 ETO29989.1 - 0.058 13.0 0.0 0.17 11.5 0.0 1.8 1 0 0 1 1 1 0 Helix-turn-helix bacterial domain AAA_16 PF13191.6 ETO29989.1 - 0.11 12.9 0.0 0.23 11.8 0.0 1.5 1 0 0 1 1 1 0 AAA ATPase domain Dynamin_N PF00350.23 ETO29989.1 - 0.55 10.3 5.3 3.7 7.6 1.1 2.8 2 1 0 2 2 2 0 Dynamin family PBP1_TM PF14812.6 ETO29989.1 - 5.4 7.5 6.5 1.3 9.5 1.7 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF2070 PF09843.9 ETO29991.1 - 2.9 6.1 19.3 0.093 11.0 11.8 1.8 2 0 0 2 2 2 0 Predicted membrane protein (DUF2070) Piwi PF02171.17 ETO29993.1 - 2.5e-12 46.7 0.0 3.2e-12 46.3 0.0 1.0 1 0 0 1 1 1 1 Piwi domain PUF PF00806.19 ETO29994.1 - 2.2e-51 168.7 4.2 1.6e-08 33.7 0.0 7.6 7 0 0 7 7 7 7 Pumilio-family RNA binding repeat CPL PF08144.11 ETO29994.1 - 0.025 15.0 0.4 3.6 7.9 0.1 3.3 2 1 1 3 3 3 0 CPL (NUC119) domain PSD4 PF07631.11 ETO29995.1 - 0.024 15.2 0.4 3 8.4 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1592) PH PF00169.29 ETO29996.1 - 3.5e-06 27.5 3.6 5.1e-06 27.0 0.1 2.4 2 0 0 2 2 2 1 PH domain LPD22 PF18834.1 ETO29996.1 - 0.0057 16.8 0.4 0.012 15.8 0.4 1.5 1 0 0 1 1 1 1 Large polyvalent protein associated domain 22 PH_17 PF18012.1 ETO29996.1 - 0.019 14.7 0.0 0.055 13.2 0.0 1.8 1 0 0 1 1 1 0 PH domain Pes-10 PF07149.11 ETO29996.1 - 0.11 11.5 11.0 0.16 11.0 11.0 1.1 1 0 0 1 1 1 0 Pes-10 Cellulose_synt PF03552.14 ETO29996.1 - 6.2 5.2 5.8 8.9 4.7 5.8 1.2 1 0 0 1 1 1 0 Cellulose synthase BBP1_C PF15272.6 ETO29997.1 - 0.0015 18.4 9.4 0.0016 18.3 9.4 1.2 1 0 0 1 1 1 1 Spindle pole body component BBP1, C-terminal DASH_Spc19 PF08287.11 ETO29997.1 - 0.0057 16.6 6.8 0.0057 16.6 6.8 2.0 1 1 1 2 2 2 1 Spc19 Vps5 PF09325.10 ETO29997.1 - 0.0062 16.1 4.2 0.0086 15.6 4.2 1.2 1 0 0 1 1 1 1 Vps5 C terminal like HRDC PF00570.23 ETO29997.1 - 0.04 13.9 0.2 0.064 13.3 0.2 1.4 1 0 0 1 1 1 0 HRDC domain DUF1664 PF07889.12 ETO29997.1 - 0.048 13.7 1.2 0.067 13.2 1.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) ERM PF00769.19 ETO29997.1 - 0.067 13.0 10.5 0.079 12.8 10.5 1.1 1 0 0 1 1 1 0 Ezrin/radixin/moesin family GPS2_interact PF15784.5 ETO29997.1 - 0.079 13.4 7.4 0.088 13.3 6.9 1.5 1 1 0 1 1 1 0 G-protein pathway suppressor 2-interacting domain Jnk-SapK_ap_N PF09744.9 ETO29997.1 - 0.089 13.0 9.3 0.11 12.8 9.3 1.2 1 0 0 1 1 1 0 JNK_SAPK-associated protein-1 Baculo_PEP_C PF04513.12 ETO29997.1 - 0.1 12.6 10.5 0.13 12.3 10.5 1.0 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Med4 PF10018.9 ETO29997.1 - 0.51 10.0 9.9 1.1 8.9 9.9 1.6 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DivIC PF04977.15 ETO29997.1 - 0.75 9.6 6.1 0.55 10.0 3.1 2.1 1 1 1 2 2 2 0 Septum formation initiator APG6_N PF17675.1 ETO29997.1 - 1.4 9.5 9.7 2 9.0 8.9 1.7 1 1 1 2 2 2 0 Apg6 coiled-coil region FliD_N PF02465.18 ETO29997.1 - 2.5 8.9 9.3 4.4 8.1 8.8 1.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus DUF4337 PF14235.6 ETO29997.1 - 2.9 8.0 5.7 1.2 9.2 3.7 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4337) DUF334 PF03904.13 ETO29997.1 - 7 6.1 17.0 0.033 13.7 6.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF334) Tim17 PF02466.19 ETO29998.1 - 4e-08 33.6 0.0 8.5e-08 32.6 0.0 1.5 2 0 0 2 2 2 1 Tim17/Tim22/Tim23/Pmp24 family LRR_6 PF13516.6 ETO29999.1 - 0.0016 18.3 1.6 2.8 8.2 0.0 4.2 4 0 0 4 4 4 1 Leucine Rich repeat LRR_8 PF13855.6 ETO29999.1 - 0.047 13.5 0.2 1.9 8.3 0.0 3.2 3 1 0 3 3 3 0 Leucine rich repeat LRR_4 PF12799.7 ETO29999.1 - 0.061 13.8 2.4 0.93 10.0 0.2 3.3 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) LRR_2 PF07723.13 ETO29999.1 - 0.077 13.7 0.3 0.61 10.8 0.0 2.6 2 0 0 2 2 2 0 Leucine Rich Repeat Rab15_effector PF15208.6 ETO29999.1 - 0.11 11.7 0.0 0.17 11.1 0.0 1.2 1 0 0 1 1 1 0 Rab15 effector Piwi PF02171.17 ETO30000.1 - 0.005 16.1 0.0 0.0068 15.7 0.0 1.1 1 0 0 1 1 1 1 Piwi domain Piwi PF02171.17 ETO30001.1 - 0.002 17.4 0.0 0.0029 16.9 0.0 1.2 1 0 0 1 1 1 1 Piwi domain RGS PF00615.19 ETO30002.1 - 1.4e-05 25.3 0.1 4.5e-05 23.7 0.1 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain AMP-binding PF00501.28 ETO30003.1 - 1.3e-34 119.5 0.1 3.6e-34 118.1 0.1 1.6 1 1 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO30003.1 - 0.00016 22.6 0.0 0.00041 21.3 0.0 1.8 1 1 0 1 1 1 1 AMP-binding enzyme C-terminal domain DUF4205 PF13898.6 ETO30004.1 - 4.7e-52 177.0 0.0 2.6e-48 164.7 0.0 3.0 2 1 0 2 2 2 2 Domain of unknown function (DUF4205) zf-RanBP PF00641.18 ETO30004.1 - 0.00056 19.2 4.3 0.0011 18.2 4.3 1.5 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Vps36-NZF-N PF16988.5 ETO30004.1 - 0.38 10.2 3.7 2.2 7.8 0.6 2.7 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain tRNA-synt_1 PF00133.22 ETO30005.1 - 2.2e-09 36.1 8.2 1.1e-06 27.2 0.0 2.8 2 1 1 3 3 3 2 tRNA synthetases class I (I, L, M and V) tRNA-synt_1g PF09334.11 ETO30005.1 - 2.6e-05 23.2 0.0 2.8e-05 23.0 0.0 1.2 1 0 0 1 1 1 1 tRNA synthetases class I (M) Peptidase_C37 PF05416.12 ETO30005.1 - 0.002 16.8 4.0 0.0026 16.4 4.0 1.0 1 0 0 1 1 1 1 Southampton virus-type processing peptidase FAM176 PF14851.6 ETO30005.1 - 0.0075 15.9 0.8 0.01 15.5 0.8 1.2 1 0 0 1 1 1 1 FAM176 family RNA_pol_Rpc4 PF05132.14 ETO30005.1 - 0.019 15.4 6.2 0.027 14.9 6.2 1.1 1 0 0 1 1 1 0 RNA polymerase III RPC4 PBP1_TM PF14812.6 ETO30005.1 - 0.079 13.3 9.5 0.12 12.7 9.5 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CobT PF06213.12 ETO30005.1 - 0.11 11.9 8.9 0.14 11.6 8.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pox_Ag35 PF03286.14 ETO30005.1 - 0.11 12.2 4.4 0.14 12.0 4.4 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RR_TM4-6 PF06459.12 ETO30005.1 - 0.31 10.8 8.7 0.38 10.5 8.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 YqfQ PF14181.6 ETO30005.1 - 0.32 11.2 5.5 0.41 10.8 5.5 1.1 1 0 0 1 1 1 0 YqfQ-like protein NPR3 PF03666.13 ETO30005.1 - 0.39 9.4 1.8 0.45 9.2 1.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 CDC45 PF02724.14 ETO30005.1 - 0.44 8.8 10.2 0.53 8.5 10.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO30005.1 - 0.56 8.9 1.4 0.64 8.7 1.4 1.1 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ETO30005.1 - 0.66 10.3 8.5 0.98 9.7 8.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF3408 PF11888.8 ETO30005.1 - 0.77 9.9 11.1 1.2 9.3 11.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3408) Connexin PF00029.19 ETO30005.1 - 1.5 8.5 5.6 2 8.1 5.6 1.1 1 0 0 1 1 1 0 Connexin Auts2 PF15336.6 ETO30005.1 - 2.1 8.4 5.4 3.1 7.9 5.4 1.2 1 0 0 1 1 1 0 Autism susceptibility gene 2 protein CENP-B_dimeris PF09026.10 ETO30005.1 - 2.2 8.7 7.7 3.8 8.0 7.7 1.3 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.11 ETO30005.1 - 2.2 6.2 7.9 2.7 5.9 7.9 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DNA_pol_phi PF04931.13 ETO30005.1 - 3.4 5.7 10.6 4 5.4 10.6 1.0 1 0 0 1 1 1 0 DNA polymerase phi TFIIF_alpha PF05793.12 ETO30005.1 - 3.5 6.1 18.5 4.4 5.8 18.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) TFB6 PF17110.5 ETO30005.1 - 3.7 7.3 5.6 5.4 6.7 5.6 1.2 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Paf1 PF03985.13 ETO30005.1 - 3.9 6.4 16.1 4.9 6.0 16.1 1.1 1 0 0 1 1 1 0 Paf1 DUF4637 PF15470.6 ETO30005.1 - 5.9 6.6 13.4 8.6 6.1 13.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) HSP90 PF00183.18 ETO30005.1 - 8.5 5.1 12.7 11 4.8 12.7 1.1 1 0 0 1 1 1 0 Hsp90 protein Fmp27 PF10344.9 ETO30005.1 - 8.8 4.3 7.3 11 4.0 7.3 1.0 1 0 0 1 1 1 0 Mitochondrial protein from FMP27 CRM1_repeat_2 PF18784.1 ETO30007.1 - 0.03 13.9 0.1 0.064 12.9 0.1 1.5 1 0 0 1 1 1 0 CRM1 / Exportin repeat 2 Rtt102p PF09510.10 ETO30007.1 - 0.72 10.1 6.4 1.8 8.8 6.4 1.6 1 0 0 1 1 1 0 Rtt102p-like transcription regulator protein zf-RING_5 PF14634.6 ETO30007.1 - 0.76 9.8 8.1 3.1 7.8 6.9 2.5 2 1 0 2 2 2 0 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETO30007.1 - 2.9 8.1 8.9 16 5.7 0.3 2.9 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING PABP PF00658.18 ETO30009.1 - 8.4e-09 35.5 0.0 1.5e-08 34.7 0.0 1.4 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain Wzy_C PF04932.15 ETO30010.1 - 0.033 13.8 1.8 0.042 13.5 0.4 1.7 2 0 0 2 2 2 0 O-Antigen ligase DUF2207 PF09972.9 ETO30010.1 - 0.23 10.2 3.4 0.29 9.8 3.4 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) DUF2614 PF11023.8 ETO30010.1 - 0.29 11.2 7.5 0.37 10.9 5.0 2.1 2 1 0 2 2 2 0 Zinc-ribbon containing domain Metallophos PF00149.28 ETO30011.1 - 2.5e-30 106.5 0.1 1.4e-29 104.1 0.1 2.0 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Aph-1 PF06105.12 ETO30012.1 - 5.8e-33 114.2 24.6 5.8e-33 114.2 24.6 1.7 2 0 0 2 2 2 1 Aph-1 protein Saf_2TM PF18303.1 ETO30014.1 - 0.0077 15.8 0.2 0.011 15.3 0.2 1.4 1 0 0 1 1 1 1 SAVED-fused 2TM effector domain DctQ PF04290.12 ETO30014.1 - 0.064 13.2 0.7 0.1 12.5 0.7 1.3 1 0 0 1 1 1 0 Tripartite ATP-independent periplasmic transporters, DctQ component ATP-synt_8 PF00895.20 ETO30016.1 - 0.037 14.5 1.0 0.037 14.5 1.0 1.8 2 0 0 2 2 2 0 ATP synthase protein 8 Pkinase PF00069.25 ETO30017.1 - 5.1e-09 35.9 0.7 7.5e-08 32.1 0.0 2.4 1 1 2 3 3 3 2 Protein kinase domain NAD_binding_4 PF07993.12 ETO30018.1 - 1.3e-52 178.6 0.0 2.2e-52 177.8 0.0 1.4 1 0 0 1 1 1 1 Male sterility protein Sterile PF03015.19 ETO30018.1 - 8.9e-10 38.7 0.7 2.4e-09 37.3 0.7 1.7 1 0 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 ETO30018.1 - 0.0011 18.0 4.2 0.076 12.0 2.6 2.9 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO30018.1 - 0.0023 17.4 0.1 0.038 13.5 0.1 2.5 2 1 0 2 2 2 1 NAD dependent epimerase/dehydratase family Polysacc_synt_2 PF02719.15 ETO30018.1 - 0.094 11.8 1.3 2.5 7.2 0.3 2.9 1 1 1 2 2 2 0 Polysaccharide biosynthesis protein GDP_Man_Dehyd PF16363.5 ETO30018.1 - 0.15 11.4 0.0 4.2 6.7 0.0 2.8 3 0 0 3 3 3 0 GDP-mannose 4,6 dehydratase RRM_1 PF00076.22 ETO30019.1 - 7.3e-07 28.9 0.0 1.5e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Papo_T_antigen PF02380.15 ETO30019.1 - 0.5 10.5 6.7 1.1 9.5 6.7 1.6 1 1 0 1 1 1 0 T-antigen specific domain Thiolase_C PF02803.18 ETO30020.1 - 0.052 13.2 0.5 0.12 12.0 0.1 1.8 2 0 0 2 2 2 0 Thiolase, C-terminal domain DUF4957 PF16318.5 ETO30021.1 - 4.1 7.3 10.6 0.44 10.5 1.3 2.8 2 1 0 3 3 3 0 Domain of unknown function (DUF4957) 7tm_3 PF00003.22 ETO30022.1 - 7.2e-22 78.3 32.3 1.4e-20 74.1 32.3 2.2 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR Ribonuclease_3 PF00636.26 ETO30023.1 - 6.1e-12 46.1 0.1 4.3e-11 43.4 0.1 2.2 1 1 0 1 1 1 1 Ribonuclease III domain Ribonucleas_3_3 PF14622.6 ETO30023.1 - 4.1e-11 43.1 0.1 8.4e-10 38.9 0.1 2.2 1 1 0 1 1 1 1 Ribonuclease-III-like Ribonuclease_3 PF00636.26 ETO30024.1 - 0.14 12.8 0.0 0.62 10.7 0.0 2.1 1 0 0 1 1 1 0 Ribonuclease III domain Inositol_P PF00459.25 ETO30025.1 - 5e-65 219.7 0.0 7e-65 219.2 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family FBPase PF00316.20 ETO30025.1 - 0.081 12.4 0.0 0.14 11.6 0.0 1.3 1 0 0 1 1 1 0 Fructose-1-6-bisphosphatase, N-terminal domain YedD PF13987.6 ETO30025.1 - 0.13 12.1 0.0 0.44 10.4 0.0 1.9 2 0 0 2 2 2 0 YedD-like protein DUF4746 PF15928.5 ETO30026.1 - 0.073 12.5 21.0 0.09 12.2 21.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Spore_coat_CotO PF14153.6 ETO30026.1 - 0.25 11.3 28.0 0.31 10.9 28.0 1.1 1 0 0 1 1 1 0 Spore coat protein CotO Menin PF05053.13 ETO30026.1 - 0.3 9.4 8.0 0.32 9.3 8.0 1.0 1 0 0 1 1 1 0 Menin RR_TM4-6 PF06459.12 ETO30026.1 - 0.32 10.8 23.8 0.37 10.6 23.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 BORG_CEP PF14957.6 ETO30026.1 - 1.7 9.8 9.0 2.3 9.4 9.0 1.3 1 0 0 1 1 1 0 Cdc42 effector Zip PF02535.22 ETO30026.1 - 2.3 7.3 14.2 2.6 7.2 14.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO30026.1 - 6.1 6.8 9.3 6.8 6.7 9.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF4569 PF15133.6 ETO30026.1 - 9.9 5.8 19.5 12 5.5 19.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4569) Glyco_hydro_3_C PF01915.22 ETO30027.1 - 0.0017 18.3 0.1 0.0023 17.9 0.1 1.2 1 0 0 1 1 1 1 Glycosyl hydrolase family 3 C-terminal domain PI3_PI4_kinase PF00454.27 ETO30028.1 - 2.7e-61 207.6 0.1 3.9e-61 207.0 0.1 1.3 1 0 0 1 1 1 1 Phosphatidylinositol 3- and 4-kinase FATC PF02260.20 ETO30028.1 - 7.3e-14 51.3 0.2 1.5e-13 50.3 0.2 1.5 1 0 0 1 1 1 1 FATC domain SNase PF00565.17 ETO30030.1 - 2e-15 57.2 2.4 9.7e-09 35.7 0.1 3.5 2 2 1 3 3 3 2 Staphylococcal nuclease homologue TUDOR PF00567.24 ETO30030.1 - 0.0045 17.0 0.2 0.013 15.5 0.0 1.9 2 0 0 2 2 2 1 Tudor domain MAM1 PF10434.9 ETO30031.1 - 0.45 10.1 5.1 0.46 10.0 3.5 1.9 1 1 1 2 2 2 0 Monopolin complex protein MAM1 Ank_2 PF12796.7 ETO30032.1 - 1e-06 29.2 0.0 2.7e-06 27.9 0.0 1.8 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO30032.1 - 0.0014 18.9 0.0 1.4 9.8 0.0 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETO30032.1 - 0.035 14.7 0.1 18 6.1 0.0 2.6 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO30032.1 - 0.24 11.8 3.0 1.3 9.4 0.0 2.9 3 0 0 3 3 3 0 Ankyrin repeats (many copies) RIO1 PF01163.22 ETO30033.1 - 0.036 13.7 2.0 0.03 13.9 0.8 1.4 1 1 0 1 1 1 0 RIO1 family XK-related PF09815.9 ETO30033.1 - 1.7 7.6 8.5 0.15 11.1 3.5 1.7 2 0 0 2 2 2 0 XK-related protein DUF2070 PF09843.9 ETO30034.1 - 8.8 4.5 12.5 10 4.2 12.5 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) LisH_2 PF16045.5 ETO30036.1 - 0.079 12.0 0.6 0.25 10.4 0.6 1.9 1 0 0 1 1 1 0 LisH EMC3_TMCO1 PF01956.16 ETO30037.1 - 1.1e-15 57.8 0.5 1.3e-15 57.5 0.5 1.1 1 0 0 1 1 1 1 Integral membrane protein EMC3/TMCO1-like mRNA_decap_C PF16741.5 ETO30037.1 - 0.4 10.0 2.2 0.82 9.0 0.3 2.3 2 0 0 2 2 2 0 mRNA-decapping enzyme C-terminus COX14 PF14880.6 ETO30037.1 - 9.7 6.1 7.2 0.31 10.9 0.6 1.9 2 0 0 2 2 2 0 Cytochrome oxidase c assembly MetallophosC PF16370.5 ETO30038.1 - 0.0078 16.5 0.1 0.019 15.2 0.0 1.7 2 0 0 2 2 2 1 C terminal of Calcineurin-like phosphoesterase Acetyltransf_19 PF18015.1 ETO30039.1 - 0.04 14.1 1.8 0.18 12.0 0.0 2.7 3 0 0 3 3 3 0 Acetyltransferase (GNAT) domain GCD14_N PF14801.6 ETO30039.1 - 0.11 12.3 0.1 0.3 10.9 0.1 1.7 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit N-term C2 PF00168.30 ETO30040.1 - 5.3e-25 87.7 0.0 8.2e-25 87.1 0.0 1.4 1 0 0 1 1 1 1 C2 domain T4_neck-protein PF11649.8 ETO30040.1 - 0.049 13.0 0.1 0.12 11.6 0.0 1.6 1 1 0 1 1 1 0 Virus neck protein MMR1 PF08505.10 ETO30041.1 - 0.003 17.9 2.5 0.0034 17.7 2.5 1.1 1 0 0 1 1 1 1 Mitochondrial Myo2 receptor-related protein LMBR1 PF04791.16 ETO30041.1 - 0.0042 16.1 2.2 0.0052 15.8 2.2 1.0 1 0 0 1 1 1 1 LMBR1-like membrane protein Zip PF02535.22 ETO30041.1 - 0.17 11.0 0.2 0.19 10.9 0.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Takusan PF04822.13 ETO30043.1 - 0.059 13.3 0.3 0.11 12.4 0.3 1.5 1 0 0 1 1 1 0 Takusan DivIC PF04977.15 ETO30044.1 - 6.3 6.7 10.6 23 4.9 0.7 3.8 3 0 0 3 3 3 0 Septum formation initiator DNase_II PF03265.15 ETO30045.1 - 4.6e-70 236.5 16.4 5.2e-70 236.3 16.4 1.0 1 0 0 1 1 1 1 Deoxyribonuclease II zf-TRAF PF02176.18 ETO30046.1 - 6.9e-06 26.7 3.4 6.9e-06 26.7 3.4 3.5 2 1 1 3 3 3 2 TRAF-type zinc finger Sina PF03145.16 ETO30046.1 - 6.3e-05 23.0 4.6 6.3e-05 23.0 4.6 2.1 2 0 0 2 2 2 1 Seven in absentia protein family GAGA PF09237.11 ETO30046.1 - 0.045 13.6 0.9 0.27 11.1 0.2 2.3 2 0 0 2 2 2 0 GAGA factor YibE_F PF07907.11 ETO30046.1 - 0.19 11.2 0.1 0.3 10.6 0.1 1.2 1 0 0 1 1 1 0 YibE/F-like protein zf-TRAF_2 PF15965.5 ETO30046.1 - 4.1 7.9 17.5 0.087 13.3 7.7 3.0 1 1 2 3 3 3 0 TRAF-like zinc-finger DUF4418 PF14387.6 ETO30047.1 - 0.075 13.2 0.1 0.15 12.3 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4418) Tubulin_C PF03953.17 ETO30048.1 - 5.2e-21 75.1 0.0 7.5e-21 74.6 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Ndc1_Nup PF09531.10 ETO30049.1 - 0.45 9.1 7.6 0.52 8.9 7.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup zf-C3HC4_3 PF13920.6 ETO30050.1 - 0.00058 19.7 11.8 0.0032 17.3 10.8 2.2 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO30050.1 - 0.051 13.5 5.1 0.17 11.8 5.1 1.9 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 ASFV_J13L PF05568.11 ETO30050.1 - 0.16 11.7 0.4 0.23 11.2 0.4 1.2 1 0 0 1 1 1 0 African swine fever virus J13L protein DUF2681 PF10883.8 ETO30050.1 - 0.24 11.8 0.2 0.24 11.8 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2681) Vpu PF00558.19 ETO30050.1 - 0.37 10.6 3.3 1.3 8.9 3.3 1.8 1 0 0 1 1 1 0 Vpu protein 60KD_IMP PF02096.20 ETO30053.1 - 8.2e-06 25.8 1.0 7.9e-05 22.6 1.0 2.1 1 1 0 1 1 1 1 60Kd inner membrane protein PH_2 PF08458.10 ETO30054.1 - 0.057 13.8 1.1 0.37 11.2 0.1 2.4 2 0 0 2 2 2 0 Plant pleckstrin homology-like region PH PF00169.29 ETO30054.1 - 0.11 13.1 0.1 0.11 13.1 0.1 2.6 2 2 0 2 2 2 0 PH domain ATAD4 PF15321.6 ETO30056.1 - 1.5 10.2 6.2 3.1 9.2 6.2 1.7 1 1 0 1 1 1 0 ATPase family AAA domain containing 4 UBA_4 PF14555.6 ETO30058.1 - 0.00061 19.6 0.1 0.0025 17.6 0.1 2.0 2 0 0 2 2 2 1 UBA-like domain GABP-alpha PF11620.8 ETO30058.1 - 0.027 14.6 0.1 0.063 13.5 0.1 1.6 1 0 0 1 1 1 0 GA-binding protein alpha chain Spore_Cse60 PF10957.8 ETO30058.1 - 0.061 13.4 1.3 0.087 12.9 0.2 1.7 2 0 0 2 2 2 0 Sporulation protein Cse60 LPD5 PF18799.1 ETO30058.1 - 0.087 13.2 1.9 0.14 12.5 1.9 1.3 1 0 0 1 1 1 0 Large polyvalent protein-associated domain 5 TAP_C PF03943.13 ETO30058.1 - 0.13 11.9 0.1 1.1 8.9 0.0 2.2 2 0 0 2 2 2 0 TAP C-terminal domain CH PF00307.31 ETO30059.1 - 1.1e-14 54.6 0.0 1.4e-14 54.2 0.0 1.2 1 0 0 1 1 1 1 Calponin homology (CH) domain CDC24 PF06395.11 ETO30059.1 - 0.0049 17.1 0.0 0.041 14.1 0.0 2.1 1 1 0 1 1 1 1 CDC24 Calponin PARG_cat PF05028.14 ETO30060.1 - 9.5e-05 21.8 0.6 0.00014 21.3 0.6 1.2 1 0 0 1 1 1 1 Poly (ADP-ribose) glycohydrolase (PARG) PARG_cat PF05028.14 ETO30061.1 - 2.3e-61 208.0 1.4 3e-36 125.4 0.3 2.2 2 0 0 2 2 2 2 Poly (ADP-ribose) glycohydrolase (PARG) AKAP_110 PF05716.13 ETO30061.1 - 0.016 13.5 0.1 0.026 12.8 0.1 1.2 1 0 0 1 1 1 0 A-kinase anchor protein 110 kDa (AKAP 110) DUF2263 PF10021.9 ETO30061.1 - 0.075 13.4 0.0 0.16 12.4 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2263) AAA_11 PF13086.6 ETO30062.1 - 7.6e-10 39.0 7.0 4.8e-09 36.4 0.1 2.2 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETO30062.1 - 0.00012 21.9 0.0 0.00019 21.2 0.0 1.3 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ETO30062.1 - 0.00032 20.7 2.6 0.046 13.7 0.0 2.4 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit AAA_19 PF13245.6 ETO30062.1 - 0.00086 19.7 0.1 0.0021 18.4 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO30062.1 - 0.0029 18.0 0.0 0.0054 17.1 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO30062.1 - 0.0048 17.2 0.2 0.016 15.5 0.1 1.9 2 0 0 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO30062.1 - 0.0056 16.7 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA PF00004.29 ETO30062.1 - 0.014 15.8 0.1 0.04 14.3 0.1 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO30062.1 - 0.023 14.2 0.8 0.069 12.6 0.1 1.9 2 0 0 2 2 2 0 P-loop containing dynein motor region NACHT PF05729.12 ETO30062.1 - 0.05 13.5 0.1 1.9 8.4 0.0 2.7 3 0 0 3 3 3 0 NACHT domain AAA_25 PF13481.6 ETO30062.1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.5 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 ETO30062.1 - 0.68 8.7 6.0 0.9 8.3 6.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Menin PF05053.13 ETO30062.1 - 2.3 6.5 9.2 3.1 6.0 9.2 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO30062.1 - 4.1 6.1 5.3 5.4 5.7 5.3 1.1 1 0 0 1 1 1 0 Presenilin MAP2_projctn PF08377.10 ETO30063.1 - 0.19 9.7 1.4 0.25 9.3 1.4 1.0 1 0 0 1 1 1 0 MAP2/Tau projection domain UBA_4 PF14555.6 ETO30064.1 - 4e-06 26.5 1.0 0.03 14.1 0.0 2.3 2 0 0 2 2 2 2 UBA-like domain LysM PF01476.20 ETO30064.1 - 0.032 14.3 0.0 0.069 13.2 0.0 1.5 1 0 0 1 1 1 0 LysM domain TAP_C PF03943.13 ETO30064.1 - 0.08 12.6 0.7 0.76 9.5 0.4 2.4 1 1 1 2 2 2 0 TAP C-terminal domain TLD PF07534.16 ETO30065.1 - 1.5e-17 64.1 2.4 1.5e-17 64.1 2.4 1.8 2 0 0 2 2 2 1 TLD BUD22 PF09073.10 ETO30065.1 - 0.00098 18.6 47.9 0.00098 18.6 47.9 2.1 2 0 0 2 2 2 1 BUD22 DUF5367 PF17329.2 ETO30066.1 - 0.061 13.4 2.3 0.087 13.0 2.3 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5367) DUF3671 PF12420.8 ETO30066.1 - 0.22 11.6 2.6 0.27 11.3 2.6 1.4 1 1 0 1 1 1 0 Protein of unknown function WD40 PF00400.32 ETO30070.1 - 9.2e-61 200.4 14.7 2.2e-09 37.8 0.1 8.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30070.1 - 3e-19 69.1 2.9 0.00023 21.4 0.1 7.5 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO30070.1 - 2e-08 33.9 17.8 0.003 16.9 0.0 6.3 7 1 0 7 7 7 3 WD40-like domain Nup160 PF11715.8 ETO30070.1 - 2.5e-07 29.7 11.0 0.23 10.0 0.0 5.6 2 1 2 6 6 6 4 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO30070.1 - 2.8e-07 30.6 10.1 0.0052 17.0 0.1 5.7 6 0 0 6 6 6 2 Kelch motif Cytochrom_D1 PF02239.16 ETO30070.1 - 2.4e-06 26.3 0.5 0.004 15.7 0.1 3.2 2 1 1 4 4 4 3 Cytochrome D1 heme domain Kelch_4 PF13418.6 ETO30070.1 - 0.0011 19.0 0.1 0.0066 16.4 0.1 2.5 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO30070.1 - 0.0046 16.9 1.1 3.7 7.7 0.2 3.8 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO30070.1 - 0.013 15.5 4.6 0.58 10.2 0.1 3.7 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO30070.1 - 0.013 15.7 0.0 0.075 13.3 0.0 2.4 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO30070.1 - 0.014 15.0 1.8 1.6 8.4 0.1 3.5 4 0 0 4 4 4 0 Kelch motif DUF5570 PF17731.1 ETO30070.1 - 0.025 14.7 0.1 14 5.8 0.0 4.0 3 1 1 4 4 4 0 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO30070.1 - 0.059 12.7 0.2 3.7 6.8 0.0 3.1 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Ricin_B_lectin PF00652.22 ETO30070.1 - 1.4 9.2 6.5 0.51 10.6 0.2 3.2 3 1 1 4 4 4 0 Ricin-type beta-trefoil lectin domain CW_binding_1 PF01473.20 ETO30070.1 - 7.9 7.0 10.3 2.1 8.8 5.5 2.9 2 0 0 2 2 1 0 Putative cell wall binding repeat DUF2489 PF10675.9 ETO30071.1 - 0.041 13.8 0.1 0.1 12.5 0.1 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2489) Ribosomal_L10 PF00466.20 ETO30072.1 - 0.0018 18.4 0.1 0.0026 17.9 0.1 1.2 1 0 0 1 1 1 1 Ribosomal protein L10 DUF1378 PF07125.11 ETO30073.1 - 0.19 11.9 0.2 0.29 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1378) DUF2951 PF11166.8 ETO30074.1 - 0.0022 18.2 5.0 0.0022 18.2 5.0 1.6 1 1 0 2 2 2 1 Protein of unknown function (DUF2951) DUF1515 PF07439.11 ETO30074.1 - 0.012 15.7 1.9 0.014 15.4 1.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) TPR_MLP1_2 PF07926.12 ETO30074.1 - 0.083 12.9 13.2 0.13 12.4 13.2 1.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein Med4 PF10018.9 ETO30074.1 - 0.22 11.2 7.8 0.22 11.2 7.5 1.2 1 1 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 DUF1664 PF07889.12 ETO30074.1 - 0.48 10.5 5.4 0.47 10.5 4.5 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) DUF948 PF06103.11 ETO30074.1 - 0.5 10.7 2.5 0.67 10.2 2.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF3573 PF12097.8 ETO30074.1 - 0.71 8.6 4.3 0.56 9.0 1.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3573) YojJ PF10372.9 ETO30074.1 - 0.91 9.7 4.9 0.77 9.9 1.5 2.2 1 1 0 1 1 1 0 Bacterial membrane-spanning protein N-terminus APG6_N PF17675.1 ETO30074.1 - 3.6 8.1 14.2 9.7 6.7 14.2 1.7 1 1 0 1 1 1 0 Apg6 coiled-coil region RabGAP-TBC PF00566.18 ETO30075.1 - 1.1e-48 165.8 3.3 1.6e-48 165.2 3.3 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain ABC2_membrane PF01061.24 ETO30076.1 - 1.4e-25 89.9 17.2 1.4e-25 89.9 17.2 1.5 2 0 0 2 2 2 1 ABC-2 type transporter PDR_CDR PF06422.12 ETO30076.1 - 0.00023 21.0 1.3 0.0005 19.9 0.1 2.3 2 0 0 2 2 2 1 CDR ABC transporter HEPN_RES_NTD1 PF18870.1 ETO30076.1 - 0.45 10.7 3.8 0.84 9.8 3.8 1.4 1 0 0 1 1 1 0 HEPN/RES N-terminal domain 1 CRCB PF02537.15 ETO30076.1 - 0.53 10.6 5.5 1.9 8.9 5.5 2.1 1 1 0 1 1 1 0 CrcB-like protein, Camphor Resistance (CrcB) ABC2_membrane_3 PF12698.7 ETO30076.1 - 2.6 7.1 25.4 1 8.4 22.3 1.9 1 1 0 1 1 1 0 ABC-2 family transporter protein IL17R_fnIII_D2 PF16578.5 ETO30077.1 - 0.017 15.7 0.5 0.081 13.5 0.2 2.2 2 0 0 2 2 2 0 Interleukin 17 receptor D G6PD_C PF02781.16 ETO30078.1 - 7.7e-102 340.4 0.0 1.2e-101 339.8 0.0 1.2 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, C-terminal domain G6PD_N PF00479.22 ETO30078.1 - 1.3e-33 117.2 0.1 2.7e-33 116.1 0.1 1.5 1 0 0 1 1 1 1 Glucose-6-phosphate dehydrogenase, NAD binding domain CPSF_A PF03178.15 ETO30080.1 - 3.1e-31 108.9 0.1 7.5e-30 104.3 0.1 2.5 2 1 0 2 2 2 1 CPSF A subunit region MMS1_N PF10433.9 ETO30081.1 - 3.6e-64 217.2 0.1 1.1e-61 209.0 0.1 2.5 1 1 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Sigma70_ner PF04546.13 ETO30081.1 - 0.0047 16.8 11.0 0.29 11.0 1.7 2.2 2 0 0 2 2 2 2 Sigma-70, non-essential region DUF468 PF04318.12 ETO30081.1 - 0.11 13.2 0.5 0.32 11.7 0.5 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF468) Exog_C PF18026.1 ETO30081.1 - 0.16 12.0 0.8 0.61 10.2 0.1 2.2 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain FAM176 PF14851.6 ETO30081.1 - 0.88 9.2 14.0 1.2 8.8 3.8 2.5 2 0 0 2 2 2 0 FAM176 family DUF4598 PF15370.6 ETO30081.1 - 5.8 7.4 13.1 8.6 6.9 3.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4598) ETRAMP PF09716.10 ETO30082.1 - 0.025 14.6 0.0 0.038 14.0 0.0 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Methyltransf_9 PF08003.11 ETO30082.1 - 0.17 10.8 1.1 0.53 9.2 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF1698) MFS_1 PF07690.16 ETO30084.1 - 6.1e-28 97.8 19.1 7.2e-28 97.5 19.1 1.0 1 0 0 1 1 1 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO30084.1 - 5.1e-12 45.4 0.7 7.7e-12 44.8 0.7 1.3 1 0 0 1 1 1 1 Sugar (and other) transporter OATP PF03137.20 ETO30084.1 - 5.8e-10 38.1 7.2 5.8e-10 38.1 7.2 3.3 1 1 2 3 3 3 2 Organic Anion Transporter Polypeptide (OATP) family MFS_4 PF06779.14 ETO30084.1 - 0.00021 20.7 3.0 0.00034 20.0 3.0 1.2 1 0 0 1 1 1 1 Uncharacterised MFS-type transporter YbfB OATP PF03137.20 ETO30085.1 - 6.5e-05 21.4 1.7 6.5e-05 21.4 1.7 2.3 2 1 0 2 2 2 1 Organic Anion Transporter Polypeptide (OATP) family BAF1_ABF1 PF04684.13 ETO30086.1 - 0.019 14.1 20.7 0.024 13.7 20.7 1.1 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor FAM199X PF15814.5 ETO30086.1 - 6.4 5.7 20.2 8.8 5.3 20.2 1.4 1 0 0 1 1 1 0 Protein family FAM199X GCP_C_terminal PF04130.13 ETO30087.1 - 8.3e-20 71.5 17.1 1.1e-19 71.0 17.1 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal Bacillus_HBL PF05791.11 ETO30087.1 - 0.0038 17.1 4.5 0.0094 15.8 1.0 2.3 1 1 1 2 2 2 2 Bacillus haemolytic enterotoxin (HBL) Bud13 PF09736.9 ETO30088.1 - 0.53 10.7 10.4 0.15 12.4 7.4 1.6 1 1 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex DUF4661 PF15576.6 ETO30088.1 - 4.8 7.0 5.5 6.1 6.7 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4661) Membralin PF09746.9 ETO30088.1 - 9.9 5.1 6.0 12 4.8 6.0 1.2 1 0 0 1 1 1 0 Tumour-associated protein DUF4539 PF15072.6 ETO30089.1 - 1.3e-07 31.5 2.0 2e-07 30.9 0.6 2.0 3 0 0 3 3 3 1 Domain of unknown function (DUF4539) TPR_12 PF13424.6 ETO30090.1 - 0.23 11.8 1.2 1.9 8.9 0.1 2.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30090.1 - 0.24 11.3 1.5 29 4.7 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Metallophos PF00149.28 ETO30091.1 - 1.3e-21 78.0 0.0 2e-21 77.4 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO30091.1 - 4.8e-18 65.3 1.4 4.8e-18 65.3 1.4 2.0 2 0 0 2 2 2 1 Serine-threonine protein phosphatase N-terminal domain Sulfatase PF00884.23 ETO30092.1 - 6.7e-20 71.7 0.0 3.8e-19 69.2 0.0 2.0 2 0 0 2 2 2 1 Sulfatase DUF229 PF02995.17 ETO30092.1 - 4.3e-08 32.2 0.0 5.7e-08 31.8 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF229) AlbA_2 PF04326.14 ETO30093.1 - 1.3e-08 35.2 1.0 2.2e-08 34.5 0.1 1.8 2 0 0 2 2 2 1 Putative DNA-binding domain Suf PF05843.14 ETO30093.1 - 0.012 15.6 0.2 0.019 15.0 0.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF3391 PF11871.8 ETO30093.1 - 0.093 13.3 1.0 0.14 12.7 1.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) Uds1 PF15456.6 ETO30093.1 - 0.38 10.9 4.8 0.15 12.2 1.5 1.9 2 0 0 2 2 2 0 Up-regulated During Septation TPR_11 PF13414.6 ETO30094.1 - 4.3e-19 67.9 8.4 3.9e-06 26.4 0.1 4.3 3 1 1 4 4 4 4 TPR repeat TPR_2 PF07719.17 ETO30094.1 - 5e-15 54.3 9.2 0.0086 16.1 0.3 4.9 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30094.1 - 4.5e-14 51.6 15.5 0.0006 19.5 0.1 5.5 5 1 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30094.1 - 6.2e-14 51.0 5.2 0.0033 17.5 0.0 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO30094.1 - 2.5e-13 49.6 0.3 0.0021 18.7 0.0 4.6 3 1 2 5 5 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO30094.1 - 3e-10 40.5 1.4 0.0038 17.7 0.7 4.0 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO30094.1 - 6e-10 39.3 3.9 4.1e-06 27.0 0.5 3.8 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO30094.1 - 1.4e-09 37.7 7.3 0.002 18.4 0.1 5.2 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO30094.1 - 1.7e-07 31.8 1.5 4.7e-05 24.0 0.0 3.6 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO30094.1 - 5.2e-06 26.1 0.9 0.64 10.2 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30094.1 - 3.4e-05 23.6 4.6 0.75 9.8 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO30094.1 - 6e-05 23.4 1.5 1.9 9.3 0.1 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat NARP1 PF12569.8 ETO30094.1 - 0.0001 21.4 2.9 0.00056 19.0 2.3 2.0 1 1 1 2 2 2 1 NMDA receptor-regulated protein 1 TPR_9 PF13371.6 ETO30094.1 - 0.00014 22.0 0.1 1.5 9.0 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO30094.1 - 0.00041 20.4 1.1 8.3 6.6 0.0 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 ETO30094.1 - 0.00099 19.1 2.9 0.087 12.9 0.1 2.6 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat SNAP PF14938.6 ETO30094.1 - 0.0014 18.1 1.0 0.023 14.1 0.5 2.4 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP Sel1 PF08238.12 ETO30094.1 - 0.0018 18.9 0.3 16 6.4 0.0 3.6 3 0 0 3 3 3 0 Sel1 repeat FAT PF02259.23 ETO30094.1 - 0.0022 17.3 3.9 0.28 10.3 0.1 2.2 1 1 1 2 2 2 2 FAT domain ANAPC3 PF12895.7 ETO30094.1 - 0.0083 16.3 6.2 0.2 11.9 1.1 2.9 2 1 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 Desmo_N PF06771.11 ETO30094.1 - 0.018 15.4 0.1 12 6.3 0.1 3.2 3 0 0 3 3 3 0 Viral Desmoplakin N-terminus SHNi-TPR PF10516.9 ETO30094.1 - 0.021 14.3 1.1 4.7 6.8 0.0 3.6 3 1 1 4 4 4 0 SHNi-TPR Arg_decarb_HB PF17810.1 ETO30094.1 - 0.077 13.3 2.1 0.64 10.3 0.7 2.5 2 0 0 2 2 2 0 Arginine decarboxylase helical bundle domain TOM20_plant PF06552.12 ETO30094.1 - 0.25 11.1 3.2 3.5 7.3 0.5 2.5 1 1 0 2 2 2 0 Plant specific mitochondrial import receptor subunit TOM20 DUF5344 PF17279.2 ETO30094.1 - 2.1 9.0 4.2 4.3 8.0 0.3 2.8 3 0 0 3 3 3 0 Family of unknown function (DUF5344) PDEase_I PF00233.19 ETO30095.1 - 1.9e-74 250.4 0.0 4.2e-74 249.3 0.0 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETO30095.1 - 0.018 15.2 0.0 0.049 13.9 0.0 1.8 1 0 0 1 1 1 0 HD domain DUF2258 PF10015.9 ETO30096.1 - 0.11 12.6 0.2 0.11 12.6 0.2 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2258) Herpes_UL74 PF07982.12 ETO30096.1 - 0.29 10.0 10.0 0.51 9.2 10.0 1.3 1 0 0 1 1 1 0 Herpes UL74 glycoproteins FSA_C PF10479.9 ETO30096.1 - 1.4 7.0 16.6 3.1 5.8 16.6 1.6 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF3736 PF12540.8 ETO30096.1 - 2.6 8.1 9.2 2.1 8.5 1.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3736) Pkinase PF00069.25 ETO30097.1 - 4.9e-36 124.5 0.0 1e-35 123.4 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30097.1 - 4.6e-27 94.9 0.0 7.7e-27 94.2 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase DUF4381 PF14316.6 ETO30099.1 - 0.01 16.1 0.4 0.017 15.4 0.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) DUF2207 PF09972.9 ETO30099.1 - 0.021 13.6 0.0 0.03 13.1 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) XhlA PF10779.9 ETO30099.1 - 0.05 13.8 0.5 0.1 12.8 0.5 1.5 1 0 0 1 1 1 0 Haemolysin XhlA FixP_N PF14715.6 ETO30099.1 - 0.45 10.3 4.6 0.61 9.9 1.2 2.3 2 0 0 2 2 2 0 N-terminal domain of cytochrome oxidase-cbb3, FixP Tetraspanin PF00335.20 ETO30100.1 - 1.3e-18 67.6 13.5 1.8e-18 67.1 13.5 1.2 1 0 0 1 1 1 1 Tetraspanin family SLAC1 PF03595.17 ETO30100.1 - 1.5e-05 24.5 6.6 8.7e-05 21.9 3.5 2.1 2 0 0 2 2 2 1 Voltage-dependent anion channel DUF2070 PF09843.9 ETO30100.1 - 0.0012 17.2 4.0 0.0012 17.2 4.0 1.4 2 0 0 2 2 2 1 Predicted membrane protein (DUF2070) PhoLip_ATPase_C PF16212.5 ETO30100.1 - 0.068 12.9 5.1 0.071 12.9 1.9 2.0 2 0 0 2 2 2 0 Phospholipid-translocating P-type ATPase C-terminal SurA_N_3 PF13624.6 ETO30100.1 - 0.42 10.4 3.3 0.45 10.3 0.8 2.2 2 0 0 2 2 2 0 SurA N-terminal domain DUF2298 PF10060.9 ETO30100.1 - 0.55 8.9 7.3 0.28 9.9 5.1 1.5 2 0 0 2 2 2 0 Uncharacterized membrane protein (DUF2298) SLATT_5 PF18160.1 ETO30100.1 - 0.67 9.2 3.9 1.9 7.8 3.9 1.7 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 DUF2207 PF09972.9 ETO30100.1 - 1.5 7.5 10.1 41 2.8 10.8 2.3 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) PAP_assoc PF03828.19 ETO30101.1 - 1.4e-07 31.6 5.8 2.8e-06 27.5 0.1 3.2 3 0 0 3 3 3 2 Cid1 family poly A polymerase tRNA_NucTransf2 PF09249.11 ETO30101.1 - 0.032 14.5 1.9 0.034 14.4 0.1 2.1 2 0 0 2 2 2 0 tRNA nucleotidyltransferase, second domain GxGYxYP_C PF14323.6 ETO30101.1 - 0.075 12.9 1.0 0.13 12.1 1.0 1.3 1 0 0 1 1 1 0 GxGYxYP putative glycoside hydrolase C-terminal domain PAP_central PF04928.17 ETO30101.1 - 0.089 11.8 2.0 0.58 9.1 1.0 2.3 2 1 0 2 2 2 0 Poly(A) polymerase central domain NTP_transf_2 PF01909.23 ETO30102.1 - 1.2e-05 25.5 0.1 3.5e-05 24.0 0.0 1.8 2 0 0 2 2 2 1 Nucleotidyltransferase domain DUF2407_C PF13373.6 ETO30106.1 - 0.00056 20.1 0.0 0.00085 19.5 0.0 1.3 1 0 0 1 1 1 1 DUF2407 C-terminal domain ubiquitin PF00240.23 ETO30106.1 - 0.1 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 Ubiquitin family CDC45 PF02724.14 ETO30108.1 - 0.0002 19.8 0.8 0.00032 19.2 0.8 1.3 1 0 0 1 1 1 1 CDC45-like protein PTPRCAP PF15713.5 ETO30108.1 - 0.018 15.3 9.0 0.045 14.0 9.0 1.6 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Folliculin PF11704.8 ETO30108.1 - 0.032 14.1 0.7 0.083 12.8 0.7 1.7 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport YajC PF02699.15 ETO30108.1 - 0.25 11.2 0.0 0.25 11.2 0.0 2.2 2 0 0 2 2 2 0 Preprotein translocase subunit Paramyxo_ncap PF00973.19 ETO30108.1 - 3.8 6.3 6.5 6.2 5.6 6.5 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Sporozoite_P67 PF05642.11 ETO30108.1 - 6 4.8 7.3 9.4 4.2 7.3 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PYST-C1 PF09690.10 ETO30109.1 - 0.0067 16.2 2.3 0.012 15.4 2.3 1.5 1 0 0 1 1 1 1 Plasmodium yoelii subtelomeric region (PYST-C1) Sec34 PF04136.15 ETO30109.1 - 0.017 15.0 3.3 0.017 15.0 3.3 1.4 1 1 0 1 1 1 0 Sec34-like family HSBP1 PF06825.12 ETO30109.1 - 0.024 14.5 6.2 0.26 11.2 5.1 2.5 1 1 1 2 2 2 0 Heat shock factor binding protein 1 DUF3245 PF11595.8 ETO30109.1 - 0.035 14.6 7.2 0.043 14.3 7.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) DUF948 PF06103.11 ETO30109.1 - 0.052 13.8 3.4 0.061 13.6 2.2 1.6 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Fmp27_WPPW PF10359.9 ETO30109.1 - 0.06 12.2 8.8 0.06 12.2 8.8 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain Ocnus PF05005.15 ETO30109.1 - 0.1 12.7 0.7 0.12 12.5 0.7 1.3 1 1 0 1 1 1 0 Janus/Ocnus family (Ocnus) Tweety PF04906.13 ETO30109.1 - 0.1 11.2 2.7 0.12 11.0 2.7 1.0 1 0 0 1 1 1 0 Tweety DUF848 PF05852.11 ETO30109.1 - 0.12 12.5 6.7 0.14 12.2 6.7 1.0 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) FlaC_arch PF05377.11 ETO30109.1 - 0.12 12.8 7.3 0.18 12.3 7.3 1.3 1 0 0 1 1 1 0 Flagella accessory protein C (FlaC) PRKCSH-like PF12999.7 ETO30109.1 - 0.14 12.0 4.8 0.16 11.8 4.8 1.1 1 0 0 1 1 1 0 Glucosidase II beta subunit-like YabA PF06156.13 ETO30109.1 - 0.17 12.5 9.0 0.21 12.2 9.0 1.2 1 0 0 1 1 1 0 Initiation control protein YabA DUF4298 PF14131.6 ETO30109.1 - 0.18 11.8 6.6 0.065 13.2 3.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4298) zf-RING_9 PF13901.6 ETO30109.1 - 0.22 11.5 2.1 0.25 11.3 2.1 1.0 1 0 0 1 1 1 0 Putative zinc-RING and/or ribbon Col_cuticle_N PF01484.17 ETO30109.1 - 0.36 10.9 0.8 0.73 9.9 0.8 1.5 1 0 0 1 1 1 0 Nematode cuticle collagen N-terminal domain Allexi_40kDa PF05549.11 ETO30109.1 - 0.48 9.9 4.0 0.58 9.6 4.0 1.0 1 0 0 1 1 1 0 Allexivirus 40kDa protein DUF1043 PF06295.12 ETO30109.1 - 0.74 9.8 8.9 0.99 9.4 8.9 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) V_ATPase_I PF01496.19 ETO30109.1 - 1.7 6.5 7.5 1.7 6.5 7.5 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Jnk-SapK_ap_N PF09744.9 ETO30110.1 - 0.00063 20.0 5.2 0.00063 20.0 5.2 3.0 3 0 0 3 3 3 1 JNK_SAPK-associated protein-1 EssA PF10661.9 ETO30110.1 - 0.00083 19.2 6.6 0.00083 19.2 6.6 2.4 2 2 0 2 2 2 1 WXG100 protein secretion system (Wss), protein EssA ADIP PF11559.8 ETO30110.1 - 0.0038 17.3 4.7 0.0038 17.3 4.7 2.7 3 0 0 3 3 3 1 Afadin- and alpha -actinin-Binding Spc24 PF08286.11 ETO30110.1 - 0.77 10.0 19.8 0.22 11.8 0.6 3.8 3 1 1 4 4 4 0 Spc24 subunit of Ndc80 Qua1 PF16274.5 ETO30110.1 - 0.99 9.3 4.8 0.34 10.8 0.7 2.5 2 1 0 2 2 2 0 Qua1 domain DUF1003 PF06210.11 ETO30110.1 - 4 7.6 8.4 0.52 10.4 3.4 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF1003) PRKG1_interact PF15898.5 ETO30110.1 - 8.4 7.4 24.6 0.4 11.6 2.2 4.0 2 1 2 4 4 4 0 cGMP-dependent protein kinase interacting domain DUF1640 PF07798.11 ETO30110.1 - 8.6 6.4 15.5 0.42 10.6 5.0 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF1640) Mucin PF01456.17 ETO30111.1 - 0.0046 17.0 8.2 0.0062 16.5 8.2 1.2 1 0 0 1 1 1 1 Mucin-like glycoprotein Dicty_REP PF05086.12 ETO30111.1 - 1.1 7.2 6.1 1.2 7.0 6.1 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Proton_antipo_C PF01010.19 ETO30111.1 - 5.2 6.6 8.5 0.49 10.0 3.3 1.9 2 0 0 2 2 2 0 NADH-dehyrogenase subunit F, TMs, (complex I) C-terminus PXA PF02194.15 ETO30112.1 - 9.1e-08 32.3 0.1 3.4e-07 30.4 0.0 1.8 2 0 0 2 2 2 1 PXA domain Nexin_C PF08628.12 ETO30113.1 - 1.6e-16 60.9 0.5 1.6e-16 60.9 0.5 3.4 3 1 0 3 3 3 1 Sorting nexin C terminal PX PF00787.24 ETO30113.1 - 5.6e-10 39.2 0.6 5.6e-10 39.2 0.6 2.6 3 0 0 3 3 3 1 PX domain MscS_porin PF12795.7 ETO30114.1 - 0.0071 15.9 10.4 0.0071 15.9 10.4 2.3 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain DUF4407 PF14362.6 ETO30114.1 - 0.16 11.3 6.2 0.24 10.7 6.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3037 PF11236.8 ETO30114.1 - 0.33 11.4 6.2 0.11 12.9 1.6 2.4 2 2 0 2 2 2 0 Protein of unknown function (DUF3037) CENP-F_leu_zip PF10473.9 ETO30114.1 - 0.63 10.1 29.6 0.58 10.2 14.6 2.6 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 MctB PF11382.8 ETO30114.1 - 0.72 9.5 6.1 0.59 9.8 0.5 2.2 2 0 0 2 2 2 0 Copper transport outer membrane protein, MctB WSD PF15613.6 ETO30114.1 - 0.79 10.2 7.4 22 5.6 7.4 2.5 1 1 0 1 1 1 0 Williams-Beuren syndrome DDT (WSD), D-TOX E motif YabA PF06156.13 ETO30114.1 - 1.3 9.7 22.6 0.1 13.3 3.3 3.1 2 1 0 2 2 2 0 Initiation control protein YabA DUF3450 PF11932.8 ETO30114.1 - 1.7 7.8 20.8 1.9 7.8 3.7 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) DivIC PF04977.15 ETO30114.1 - 2 8.3 14.5 0.21 11.4 0.6 3.6 2 1 1 3 3 3 0 Septum formation initiator LMBR1 PF04791.16 ETO30114.1 - 2.2 7.1 9.3 3 6.7 9.3 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Lebercilin PF15619.6 ETO30114.1 - 2.6 7.6 28.0 0.5 10.0 17.7 2.4 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SOGA PF11365.8 ETO30114.1 - 2.9 9.1 17.2 0.19 12.8 3.9 2.9 2 1 1 3 3 3 0 Protein SOGA TFIIA PF03153.13 ETO30114.1 - 3.2 7.6 13.4 4.1 7.3 13.4 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF763 PF05559.11 ETO30114.1 - 4.8 6.3 9.4 0.65 9.1 4.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF763) PikAIV_N PF18605.1 ETO30114.1 - 8.6 6.0 10.7 2.7 7.7 4.8 2.6 2 0 0 2 2 2 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain FtsL PF04999.13 ETO30114.1 - 9.1 6.4 10.4 2 8.5 0.3 3.0 2 1 0 2 2 2 0 Cell division protein FtsL POX PF07526.11 ETO30114.1 - 9.2 6.8 14.2 1.6 9.3 6.1 2.3 2 0 0 2 2 2 0 Associated with HOX DUF4618 PF15397.6 ETO30115.1 - 6.1e-05 22.6 5.4 7.1e-05 22.4 5.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4618) DUF1640 PF07798.11 ETO30115.1 - 0.0013 18.8 0.4 0.0016 18.6 0.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1640) CdvA PF18822.1 ETO30115.1 - 0.0017 18.2 6.3 0.002 17.9 6.3 1.1 1 0 0 1 1 1 1 CdvA-like coiled-coil domain DASH_Dad2 PF08654.10 ETO30115.1 - 0.004 17.5 2.2 0.0054 17.1 2.2 1.1 1 0 0 1 1 1 1 DASH complex subunit Dad2 DUF3713 PF12506.8 ETO30115.1 - 0.019 15.3 1.1 0.023 15.0 1.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3713) Apolipoprotein PF01442.18 ETO30115.1 - 0.033 14.0 3.3 0.04 13.8 3.3 1.0 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain 60KD_IMP PF02096.20 ETO30115.1 - 0.072 13.0 2.5 0.089 12.7 2.5 1.2 1 0 0 1 1 1 0 60Kd inner membrane protein Med21 PF11221.8 ETO30115.1 - 0.26 11.6 5.6 0.29 11.4 5.6 1.1 1 0 0 1 1 1 0 Subunit 21 of Mediator complex CHD5 PF04420.14 ETO30115.1 - 0.37 10.6 4.1 1.2 9.0 0.4 2.0 1 1 1 2 2 2 0 CHD5-like protein VPS11_C PF12451.8 ETO30115.1 - 1 9.7 3.7 0.66 10.2 1.4 1.8 1 1 1 2 2 2 0 Vacuolar protein sorting protein 11 C terminal BPS1 PF05633.11 ETO30115.1 - 1.4 7.8 5.8 0.31 10.0 2.7 1.3 1 1 0 1 1 1 0 Protein BYPASS1-related His_Phos_1 PF00300.22 ETO30116.1 - 0.00038 20.2 0.0 0.00042 20.1 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) DUF1664 PF07889.12 ETO30117.1 - 0.023 14.8 3.2 0.023 14.8 3.2 4.6 4 1 1 5 5 5 0 Protein of unknown function (DUF1664) MCPsignal PF00015.21 ETO30117.1 - 3.7 7.3 17.4 0.53 10.1 1.5 2.9 3 0 0 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain CS PF04969.16 ETO30118.1 - 3.2e-08 34.5 0.2 4.7e-08 33.9 0.2 1.3 1 0 0 1 1 1 1 CS domain Macoilin PF09726.9 ETO30118.1 - 8.6 4.8 9.9 10 4.5 9.9 1.1 1 0 0 1 1 1 0 Macoilin family EF-hand_1 PF00036.32 ETO30119.1 - 1e-18 65.4 8.2 1.1e-05 24.6 0.1 4.4 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO30119.1 - 8.3e-17 61.4 4.3 1e-09 38.7 0.3 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO30119.1 - 1.6e-14 52.5 2.5 0.00035 20.3 0.0 4.3 4 0 0 4 4 4 3 EF-hand domain CAP_GLY PF01302.25 ETO30119.1 - 4.3e-14 52.3 1.2 1e-13 51.1 1.2 1.7 1 0 0 1 1 1 1 CAP-Gly domain EF-hand_5 PF13202.6 ETO30119.1 - 5.8e-12 44.5 7.6 0.00047 19.5 0.1 4.3 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO30119.1 - 9.7e-11 41.4 3.3 2.8e-05 23.8 0.2 4.1 3 1 1 4 4 4 3 EF-hand domain pair Cbl_N2 PF02761.14 ETO30119.1 - 0.0014 19.3 6.6 0.45 11.3 0.7 2.7 3 0 0 3 3 3 2 CBL proto-oncogene N-terminus, EF hand-like domain EF-hand_10 PF14788.6 ETO30119.1 - 0.0022 17.8 1.2 0.13 12.1 0.0 2.9 3 0 0 3 3 3 1 EF hand LytR_cpsA_psr PF03816.14 ETO30119.1 - 0.024 14.8 0.0 0.041 14.0 0.0 1.4 1 0 0 1 1 1 0 Cell envelope-related transcriptional attenuator domain APP_E2 PF12925.7 ETO30119.1 - 0.036 13.8 0.7 0.058 13.1 0.0 1.6 2 0 0 2 2 2 0 E2 domain of amyloid precursor protein Hint_2 PF13403.6 ETO30119.1 - 0.041 14.2 0.1 0.084 13.2 0.1 1.4 1 0 0 1 1 1 0 Hint domain SPARC_Ca_bdg PF10591.9 ETO30119.1 - 0.048 14.0 4.8 0.61 10.4 0.1 2.9 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_11 PF08976.11 ETO30119.1 - 0.058 14.3 0.5 1.4 9.8 0.1 2.4 1 1 1 2 2 2 0 EF-hand domain C-C_Bond_Lyase PF15617.6 ETO30119.1 - 0.1 11.7 0.1 0.16 11.1 0.1 1.2 1 0 0 1 1 1 0 C-C_Bond_Lyase of the TIM-Barrel fold adh_short_C2 PF13561.6 ETO30122.1 - 2.2e-48 164.9 0.1 2.8e-48 164.5 0.1 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO30122.1 - 8.5e-48 162.4 0.5 1e-47 162.1 0.5 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO30122.1 - 1.7e-08 34.6 0.1 2.9e-08 33.9 0.1 1.3 1 0 0 1 1 1 1 KR domain 3HCDH_N PF02737.18 ETO30122.1 - 0.0052 16.7 0.2 0.0093 15.9 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Polysacc_synt_2 PF02719.15 ETO30122.1 - 0.038 13.1 0.1 0.055 12.6 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Epimerase PF01370.21 ETO30122.1 - 0.12 11.8 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family COesterase PF00135.28 ETO30124.1 - 8.9e-100 335.0 0.0 1.2e-99 334.6 0.0 1.1 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETO30124.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.6 1 1 0 1 1 1 0 alpha/beta hydrolase fold Peptidase_S9 PF00326.21 ETO30124.1 - 0.082 12.4 0.0 0.16 11.4 0.0 1.4 1 0 0 1 1 1 0 Prolyl oligopeptidase family PG_binding_1 PF01471.18 ETO30126.1 - 5.2e-20 71.4 0.1 9.4e-20 70.6 0.1 1.5 1 0 0 1 1 1 1 Putative peptidoglycan binding domain Peptidase_M10 PF00413.24 ETO30126.1 - 1.3e-07 31.6 0.0 2e-07 31.0 0.0 1.3 1 0 0 1 1 1 1 Matrixin PG_binding_2 PF08823.11 ETO30126.1 - 0.0016 18.7 0.1 0.0039 17.5 0.1 1.6 1 1 0 1 1 1 1 Putative peptidoglycan binding domain PG_binding_3 PF09374.10 ETO30126.1 - 0.0018 18.5 0.0 0.0033 17.6 0.0 1.5 1 0 0 1 1 1 1 Predicted Peptidoglycan domain Tyosinase_C PF18132.1 ETO30126.1 - 0.0031 18.2 0.0 0.0096 16.6 0.0 1.7 1 1 0 1 1 1 1 Tyosinase C-terminal domain CSN7a_helixI PF18392.1 ETO30126.1 - 0.072 13.0 0.6 0.14 12.1 0.6 1.5 1 0 0 1 1 1 0 COP9 signalosome complex subunit 7a helix I domain P53_C PF11619.8 ETO30127.1 - 0.19 11.8 0.2 0.39 10.8 0.2 1.4 1 0 0 1 1 1 0 Transcription factor P53 - C terminal domain adh_short PF00106.25 ETO30128.1 - 2.4e-19 69.5 0.0 5.3e-19 68.5 0.0 1.5 1 1 0 1 1 1 1 short chain dehydrogenase Polysacc_synt_2 PF02719.15 ETO30128.1 - 2.3e-06 27.0 0.2 4e-06 26.2 0.0 1.5 2 0 0 2 2 2 1 Polysaccharide biosynthesis protein KR PF08659.10 ETO30128.1 - 3.4e-05 23.8 0.0 5e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ETO30128.1 - 0.00016 21.3 0.0 0.00024 20.8 0.0 1.2 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Eno-Rase_NADH_b PF12242.8 ETO30128.1 - 0.0051 16.5 0.9 1.5 8.7 0.1 2.7 2 1 0 2 2 2 2 NAD(P)H binding domain of trans-2-enoyl-CoA reductase PDEase_I PF00233.19 ETO30128.1 - 0.074 12.8 0.2 0.11 12.2 0.2 1.2 1 0 0 1 1 1 0 3'5'-cyclic nucleotide phosphodiesterase Secretin_N_2 PF07655.13 ETO30129.1 - 2.1 8.9 18.7 0.93 10.1 13.8 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain Menin PF05053.13 ETO30129.1 - 2.6 6.3 5.9 4.5 5.5 5.9 1.3 1 0 0 1 1 1 0 Menin CRM1_C PF08767.11 ETO30130.1 - 0.00028 20.1 3.9 0.00032 20.0 3.9 1.2 1 0 0 1 1 1 1 CRM1 C terminal YCF90 PF17088.5 ETO30130.1 - 0.012 14.9 2.3 0.41 9.9 0.9 2.0 2 0 0 2 2 2 0 Uncharacterised protein family SirB PF04247.12 ETO30130.1 - 1.3 9.1 7.2 0.24 11.5 2.2 2.1 3 0 0 3 3 3 0 Invasion gene expression up-regulator, SirB Dynein_light PF01221.18 ETO30131.1 - 3.6e-34 116.9 1.4 3.6e-34 116.9 1.4 2.3 2 0 0 2 2 2 1 Dynein light chain type 1 Aminotran_1_2 PF00155.21 ETO30132.1 - 2.7e-27 95.9 0.5 4.8e-17 62.2 0.1 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II HydF_dimer PF18128.1 ETO30132.1 - 0.18 11.9 0.8 0.36 10.9 0.3 1.7 2 0 0 2 2 2 0 Hydrogen maturase F dimerization domain DUF493 PF04359.14 ETO30132.1 - 0.23 12.1 3.6 0.96 10.1 0.2 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF493) Pkinase PF00069.25 ETO30133.1 - 6e-20 71.7 0.0 7.7e-20 71.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30133.1 - 0.072 12.4 0.0 0.17 11.1 0.0 1.7 1 1 0 1 1 1 0 Protein tyrosine kinase Castor1_N PF18700.1 ETO30133.1 - 0.092 12.6 0.2 0.56 10.1 0.1 2.1 2 0 0 2 2 2 0 Cytosolic arginine sensor for mTORC1 subunit 1 N-terminal domain PARP PF00644.20 ETO30134.1 - 1.9e-67 226.6 0.0 3.1e-67 226.0 0.0 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain PARP_reg PF02877.14 ETO30134.1 - 7.2e-37 126.5 0.3 1.1e-36 126.0 0.3 1.3 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase, regulatory domain DUF2797 PF10977.8 ETO30134.1 - 0.09 12.7 0.1 16 5.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2797) Abhydro_lipase PF04083.16 ETO30134.1 - 0.15 11.6 0.1 0.42 10.2 0.1 1.7 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region WGR PF05406.15 ETO30135.1 - 5.5e-24 84.0 2.8 5.5e-24 84.0 2.8 3.7 3 0 0 3 3 3 2 WGR domain BRCT PF00533.26 ETO30135.1 - 1.9e-12 47.4 0.5 8.1e-12 45.4 0.5 2.2 1 0 0 1 1 1 1 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ETO30135.1 - 2.8e-10 40.5 0.3 1.2e-09 38.5 0.1 2.3 2 0 0 2 2 2 1 BRCT domain, a BRCA1 C-terminus domain MPM1 PF17234.2 ETO30135.1 - 0.0036 17.6 3.7 0.0036 17.6 3.7 3.9 4 0 0 4 4 4 1 Mitochondrial peculiar membrane protein 1 Radial_spoke PF04712.12 ETO30135.1 - 0.017 14.1 17.1 0.54 9.1 1.3 3.1 3 0 0 3 3 3 0 Radial spokehead-like protein CLN3 PF02487.17 ETO30135.1 - 0.25 10.4 4.8 0.14 11.2 0.3 2.2 2 0 0 2 2 2 0 CLN3 protein Folate_carrier PF01770.18 ETO30135.1 - 3.2 6.4 7.2 1.4 7.6 0.5 2.4 2 0 0 2 2 2 0 Reduced folate carrier BRF1 PF07741.13 ETO30135.1 - 6.8 7.1 34.8 0.14 12.5 5.2 4.3 4 0 0 4 4 4 0 Brf1-like TBP-binding domain Borrelia_orfD PF02999.14 ETO30136.1 - 0.16 12.3 1.5 1.6 9.1 0.1 2.6 2 0 0 2 2 2 0 Borrelia orf-D family tRNA-synt_2b PF00587.25 ETO30137.1 - 0.057 13.4 0.1 0.062 13.3 0.1 1.1 1 0 0 1 1 1 0 tRNA synthetase class II core domain (G, H, P, S and T) DTW PF03942.15 ETO30139.1 - 7.4e-18 65.0 0.0 7.4e-18 65.0 0.0 2.3 3 0 0 3 3 3 1 DTW domain zinc_ribbon_16 PF17034.5 ETO30139.1 - 0.017 15.3 0.7 0.041 14.1 0.4 1.8 2 0 0 2 2 2 0 Zinc-ribbon like family zf-B_box PF00643.24 ETO30139.1 - 0.12 12.6 1.7 0.27 11.4 1.7 1.7 1 0 0 1 1 1 0 B-box zinc finger DUF3984 PF13136.6 ETO30139.1 - 0.3 10.5 3.9 0.42 10.0 0.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3984) Nudix_N_2 PF14803.6 ETO30139.1 - 0.51 10.3 3.2 17 5.4 1.0 2.6 2 0 0 2 2 2 0 Nudix N-terminal Pkinase PF00069.25 ETO30142.1 - 9.5e-23 80.9 0.6 1.2e-22 80.6 0.6 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30142.1 - 6.1e-13 48.7 0.6 1.5e-12 47.3 0.6 1.5 1 1 1 2 2 2 2 Protein tyrosine kinase PQQ PF01011.21 ETO30142.1 - 0.2 11.7 0.1 4.9 7.3 0.1 2.2 2 0 0 2 2 2 0 PQQ enzyme repeat Pkinase PF00069.25 ETO30143.1 - 3.9e-36 124.8 0.0 5.3e-36 124.3 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30143.1 - 3.3e-12 46.3 0.1 2.4e-11 43.4 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Pox_ser-thr_kin PF05445.11 ETO30143.1 - 0.0059 15.6 0.2 0.19 10.7 0.1 2.1 2 0 0 2 2 2 2 Poxvirus serine/threonine protein kinase WD40 PF00400.32 ETO30146.1 - 3.6e-60 198.5 19.7 4.8e-10 39.9 0.0 7.4 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30146.1 - 1.2e-14 54.4 1.9 0.021 15.1 0.1 6.1 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30146.1 - 2.4e-13 49.7 0.3 0.033 13.2 0.0 6.5 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO30146.1 - 6.1e-09 36.0 0.8 3.3e-05 23.9 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO30146.1 - 9.2e-05 21.9 2.0 0.46 9.8 0.0 3.4 1 1 2 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO30146.1 - 0.00015 20.4 0.0 0.0025 16.4 0.0 2.3 1 1 2 3 3 3 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO30146.1 - 0.0061 15.3 8.3 5.2 5.6 0.1 4.9 1 1 2 5 5 5 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO30146.1 - 0.012 15.6 1.3 36 4.4 0.0 4.9 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO30146.1 - 0.013 15.6 0.1 0.64 10.2 0.0 3.3 4 0 0 4 4 4 0 Strictosidine synthase nos_propeller PF18764.1 ETO30146.1 - 0.014 15.3 1.1 5.5 7.0 0.1 4.3 5 1 1 6 6 6 0 Nitrous oxide reductase propeller repeat DUF5570 PF17731.1 ETO30146.1 - 0.018 15.1 0.2 3.3 7.8 0.1 3.8 2 1 2 4 4 4 0 Family of unknown function (DUF5570) HARP PF07443.13 ETO30146.1 - 0.052 13.2 0.0 5.9 6.6 0.0 3.7 4 0 0 4 4 4 0 HepA-related protein (HARP) WD40 PF00400.32 ETO30147.1 - 6.3e-67 219.9 28.0 3e-09 37.3 0.2 7.8 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30147.1 - 1.2e-15 57.6 2.8 0.00093 19.5 0.0 5.9 2 1 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30147.1 - 1.5e-08 34.0 0.4 0.073 12.0 0.0 6.2 1 1 0 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO30147.1 - 7.6e-06 26.0 7.1 0.00011 22.3 0.1 4.4 4 1 1 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO30147.1 - 3.5e-05 23.7 0.6 0.00034 20.5 1.0 2.4 2 1 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO30147.1 - 3.6e-05 23.2 0.1 0.00018 21.0 0.1 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO30147.1 - 5.8e-05 23.3 0.1 0.00028 21.1 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO30147.1 - 6.1e-05 23.0 0.1 0.0061 16.5 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain DUF1258 PF06869.12 ETO30147.1 - 0.0003 20.4 2.8 0.89 9.0 0.1 3.4 2 1 2 4 4 4 2 Protein of unknown function (DUF1258) PD40 PF07676.12 ETO30147.1 - 0.0025 17.7 0.8 1.6 8.8 0.0 4.2 5 0 0 5 5 4 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO30147.1 - 0.0033 16.4 3.2 0.037 12.9 0.0 3.3 1 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO30147.1 - 0.0049 17.0 0.3 64 3.7 0.0 4.1 2 2 2 4 4 4 0 Family of unknown function (DUF5570) Kelch_2 PF07646.15 ETO30147.1 - 0.0073 16.3 0.0 0.047 13.7 0.0 2.5 1 0 0 1 1 1 1 Kelch motif SBD PF17882.1 ETO30147.1 - 0.091 12.6 0.4 31 4.4 0.0 3.3 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain Proteasome_A_N PF10584.9 ETO30147.1 - 3.4 7.4 6.8 16 5.3 0.1 3.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF3868 PF12984.7 ETO30148.1 - 0.084 12.7 0.6 0.96 9.3 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function, B. Theta Gene description (DUF3868) EF-hand_7 PF13499.6 ETO30150.1 - 0.0065 16.9 0.5 0.021 15.2 0.5 1.9 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO30150.1 - 0.036 14.0 0.2 2 8.6 0.1 2.8 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 ETO30150.1 - 0.16 11.6 0.9 6 6.7 0.4 2.7 2 0 0 2 2 2 0 EF hand DUF1180 PF06679.12 ETO30152.1 - 0.075 13.5 0.3 0.12 12.8 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DMA PF03474.14 ETO30153.1 - 0.14 11.8 0.0 0.38 10.4 0.0 1.7 2 0 0 2 2 2 0 DMRTA motif Pkinase PF00069.25 ETO30154.1 - 4.6e-09 36.0 0.0 9.9e-09 34.9 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30154.1 - 0.00036 19.9 0.0 0.00071 18.9 0.0 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase UPF0370 PF13980.6 ETO30155.1 - 6.7 6.8 9.3 0.37 10.9 0.6 2.4 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0370) Ank_2 PF12796.7 ETO30156.1 - 3.1e-31 107.8 0.9 2e-15 57.1 0.1 3.2 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO30156.1 - 9.6e-26 89.8 1.6 3.4e-08 33.9 0.1 4.6 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO30156.1 - 3.7e-24 82.2 3.1 0.002 18.4 0.0 6.0 5 1 1 6 6 6 5 Ankyrin repeat Ank PF00023.30 ETO30156.1 - 3.8e-24 84.0 2.0 1.5e-05 25.2 0.1 5.3 4 1 1 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 ETO30156.1 - 2.9e-20 72.1 1.4 0.00023 21.4 0.0 4.5 1 1 3 4 4 4 4 Ankyrin repeats (many copies) Baculo_gp64 PF03273.13 ETO30156.1 - 0.052 12.4 0.3 0.076 11.8 0.3 1.2 1 0 0 1 1 1 0 Baculovirus gp64 envelope glycoprotein family adh_short PF00106.25 ETO30157.1 - 3.5e-44 150.6 2.1 5.6e-43 146.7 2.1 2.3 1 1 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO30157.1 - 1e-30 107.0 0.0 1.7e-16 60.5 0.0 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO30157.1 - 7.1e-06 26.0 0.0 7.8e-05 22.7 0.0 2.1 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 ETO30157.1 - 1.3e-05 25.2 0.0 0.00015 21.7 0.0 2.0 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETO30157.1 - 0.0013 18.2 0.1 0.0029 17.1 0.0 1.6 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NmrA PF05368.13 ETO30157.1 - 0.042 13.4 0.0 0.079 12.5 0.0 1.5 1 0 0 1 1 1 0 NmrA-like family YMF19 PF02326.15 ETO30157.1 - 1.6 9.5 7.3 12 6.8 0.2 2.7 2 0 0 2 2 2 0 Plant ATP synthase F0 EF-hand_1 PF00036.32 ETO30158.1 - 2.3e-18 64.3 12.7 6.1e-06 25.4 0.0 4.7 5 1 0 5 5 5 4 EF hand EF-hand_6 PF13405.6 ETO30158.1 - 7.3e-16 56.7 4.5 9.7e-05 22.0 0.1 4.5 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO30158.1 - 7.7e-16 56.8 6.6 2.3e-05 23.7 0.1 4.5 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO30158.1 - 6.1e-15 55.4 4.3 2.7e-09 37.3 0.2 3.0 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO30158.1 - 1.4e-09 37.6 2.3 0.052 13.4 0.0 4.1 4 0 0 4 4 4 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO30158.1 - 0.00078 19.4 3.5 0.12 12.3 0.0 3.3 2 1 2 4 4 4 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO30158.1 - 0.001 19.4 4.1 0.55 10.6 0.1 3.2 2 1 1 3 3 3 2 Secreted protein acidic and rich in cysteine Ca binding region DUF1617 PF07761.12 ETO30158.1 - 0.028 14.5 0.2 0.19 11.8 0.0 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1617) DNA_pol3_beta_2 PF02767.16 ETO30160.1 - 0.065 13.5 0.0 0.14 12.4 0.0 1.5 1 0 0 1 1 1 0 DNA polymerase III beta subunit, central domain Sel1 PF08238.12 ETO30161.1 - 8.8e-15 54.8 4.0 4.8e-05 23.9 0.0 4.2 4 1 0 4 4 4 3 Sel1 repeat TPR_6 PF13174.6 ETO30161.1 - 0.055 14.1 0.9 3.6 8.4 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat HIT PF01230.23 ETO30162.1 - 3.3e-24 85.5 0.0 5.9e-24 84.7 0.0 1.4 1 0 0 1 1 1 1 HIT domain DcpS_C PF11969.8 ETO30162.1 - 1.4e-09 38.4 0.0 2.7e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Ras PF00071.22 ETO30163.1 - 2.8e-37 127.8 8.0 5e-27 94.5 0.3 3.4 2 1 1 3 3 3 3 Ras family Roc PF08477.13 ETO30163.1 - 2.9e-21 75.9 5.1 5.2e-10 39.6 0.1 3.4 2 1 1 3 3 3 3 Ras of Complex, Roc, domain of DAPkinase MMR_HSR1 PF01926.23 ETO30163.1 - 0.0013 18.8 0.2 0.84 9.7 0.1 2.3 2 0 0 2 2 2 2 50S ribosome-binding GTPase Arf PF00025.21 ETO30163.1 - 0.0015 18.0 0.6 0.091 12.2 0.0 2.7 2 1 1 3 3 3 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO30163.1 - 0.042 13.2 3.2 3.3 7.0 0.1 2.8 3 1 0 3 3 3 0 Gtr1/RagA G protein conserved region adh_short PF00106.25 ETO30164.1 - 6e-26 91.1 0.1 7.9e-21 74.4 0.1 2.3 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO30164.1 - 1.6e-13 50.7 0.0 2e-08 34.1 0.0 2.3 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO30164.1 - 0.00022 21.2 0.0 0.00035 20.5 0.0 1.3 1 0 0 1 1 1 1 KR domain zf-C3HC4_3 PF13920.6 ETO30165.1 - 7.3e-10 38.6 21.3 7.3e-10 38.6 21.3 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Neur_chan_memb PF02932.16 ETO30165.1 - 0.0039 17.3 1.7 0.0062 16.6 1.7 1.2 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Prok-RING_4 PF14447.6 ETO30165.1 - 0.0044 16.9 20.2 0.0044 16.9 20.2 2.0 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 YusW PF14039.6 ETO30165.1 - 0.21 12.1 4.6 0.6 10.7 4.6 1.8 1 0 0 1 1 1 0 YusW-like protein Prp18 PF02840.15 ETO30165.1 - 6.8 6.7 7.6 1.5 8.9 0.1 2.7 2 1 1 3 3 3 0 Prp18 domain DUF713 PF05218.14 ETO30166.1 - 0.0023 17.7 5.0 0.0029 17.3 5.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF713) Multi-haem_cyto PF13447.6 ETO30166.1 - 0.0051 16.1 1.8 0.0064 15.8 1.8 1.3 1 1 0 1 1 1 1 Seven times multi-haem cytochrome CxxCH DUF2681 PF10883.8 ETO30166.1 - 0.036 14.5 4.2 0.061 13.7 4.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) CRA PF06589.11 ETO30166.1 - 0.042 13.9 12.3 2.9 8.0 12.3 2.1 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) DUF4407 PF14362.6 ETO30166.1 - 0.076 12.3 4.9 0.092 12.1 4.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CHDCT2 PF08074.11 ETO30166.1 - 0.079 13.1 1.5 0.11 12.6 1.5 1.2 1 0 0 1 1 1 0 CHDCT2 (NUC038) domain DUF4337 PF14235.6 ETO30166.1 - 0.12 12.5 3.3 0.2 11.8 3.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) GAS PF13851.6 ETO30166.1 - 0.13 11.6 12.2 0.03 13.7 7.2 1.9 2 0 0 2 2 2 0 Growth-arrest specific micro-tubule binding DUF3573 PF12097.8 ETO30166.1 - 0.18 10.6 1.3 0.18 10.6 1.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) DUF1517 PF07466.11 ETO30166.1 - 0.25 11.4 3.7 0.31 11.1 3.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF1517) MRPL52 PF18699.1 ETO30166.1 - 3.7 7.8 12.3 17 5.7 10.9 2.3 1 1 1 2 2 2 0 Mitoribosomal protein mL52 Tho2 PF11262.8 ETO30166.1 - 3.7 6.7 11.0 3.5 6.7 10.0 1.4 1 1 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Ras PF00071.22 ETO30167.1 - 0.00014 21.5 0.0 0.00023 20.8 0.0 1.4 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO30167.1 - 0.015 15.6 0.4 0.058 13.6 0.0 2.2 1 1 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase Presenilin PF01080.17 ETO30167.1 - 0.054 12.3 3.7 0.078 11.7 3.7 1.3 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 ETO30167.1 - 0.063 12.6 4.1 0.09 12.1 4.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) AAA_14 PF13173.6 ETO30167.1 - 0.16 12.0 2.2 0.25 11.4 0.0 2.3 1 1 1 2 2 2 0 AAA domain HCO3_cotransp PF00955.21 ETO30167.1 - 1.2 7.9 3.3 1.4 7.7 3.3 1.2 1 0 0 1 1 1 0 HCO3- transporter family NOA36 PF06524.12 ETO30167.1 - 5 6.4 8.9 7.3 5.8 8.9 1.2 1 0 0 1 1 1 0 NOA36 protein MAP70 PF07058.11 ETO30167.1 - 6.2 5.4 10.7 8.8 4.9 10.7 1.2 1 0 0 1 1 1 0 Microtubule-associated protein 70 DcpS_C PF11969.8 ETO30168.1 - 1.7e-12 47.8 1.1 7.2e-12 45.8 1.1 2.1 1 1 0 1 1 1 1 Scavenger mRNA decapping enzyme C-term binding Helitron_like_N PF14214.6 ETO30168.1 - 0.0081 16.4 0.0 0.024 14.9 0.0 1.8 2 0 0 2 2 2 1 Helitron helicase-like domain at N-terminus DHO_dh PF01180.21 ETO30169.1 - 3.8e-35 121.5 0.0 4.9e-35 121.2 0.0 1.1 1 0 0 1 1 1 1 Dihydroorotate dehydrogenase NMO PF03060.15 ETO30169.1 - 0.014 14.8 0.0 0.018 14.5 0.0 1.1 1 0 0 1 1 1 0 Nitronate monooxygenase SAM_1 PF00536.30 ETO30170.1 - 1.3e-12 48.0 0.2 2.1e-12 47.3 0.2 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO30170.1 - 4.6e-09 36.3 0.1 8e-09 35.5 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) bZIP_1 PF00170.21 ETO30170.1 - 0.039 14.0 2.8 0.039 14.0 2.8 2.4 2 0 0 2 2 2 0 bZIP transcription factor TFR_dimer PF04253.15 ETO30170.1 - 0.11 12.6 0.8 0.16 12.1 0.8 1.4 1 0 0 1 1 1 0 Transferrin receptor-like dimerisation domain Uso1_p115_C PF04871.13 ETO30170.1 - 0.21 11.9 12.0 0.28 11.6 12.0 1.2 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region KfrA_N PF11740.8 ETO30170.1 - 0.31 11.7 7.8 2.1 9.0 1.2 2.2 1 1 1 2 2 2 0 Plasmid replication region DNA-binding N-term DUF4472 PF14739.6 ETO30170.1 - 0.38 11.5 10.0 0.58 10.9 10.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4472) FlxA PF14282.6 ETO30170.1 - 0.47 10.5 10.1 1.6 8.7 10.1 1.8 1 1 0 1 1 1 0 FlxA-like protein OmpH PF03938.14 ETO30170.1 - 0.52 10.7 11.2 0.88 9.9 11.2 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 ETO30170.1 - 0.66 9.3 4.1 0.8 9.0 4.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ADIP PF11559.8 ETO30170.1 - 0.74 9.9 7.8 6 6.9 7.8 2.1 1 1 1 2 2 2 0 Afadin- and alpha -actinin-Binding PRKG1_interact PF15898.5 ETO30170.1 - 0.77 10.7 10.5 0.32 11.9 8.1 1.6 2 0 0 2 2 1 0 cGMP-dependent protein kinase interacting domain Cnn_1N PF07989.11 ETO30170.1 - 0.81 9.9 10.1 0.17 12.1 3.8 2.3 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 FapA PF03961.13 ETO30170.1 - 0.92 8.0 5.9 1.1 7.7 5.9 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_11 PF13086.6 ETO30170.1 - 1 9.1 5.9 1.3 8.7 5.9 1.2 1 0 0 1 1 1 0 AAA domain ZapB PF06005.12 ETO30170.1 - 1.3 9.5 12.3 0.39 11.2 9.1 1.8 2 1 0 2 2 1 0 Cell division protein ZapB Ax_dynein_light PF10211.9 ETO30170.1 - 2.8 7.9 12.2 6.8 6.6 12.2 1.7 1 1 0 1 1 1 0 Axonemal dynein light chain Swi5 PF07061.11 ETO30170.1 - 6.3 7.0 9.5 6.1 7.0 5.9 2.3 1 1 1 2 2 2 0 Swi5 CCDC-167 PF15188.6 ETO30170.1 - 8.8 6.7 10.6 4.5 7.7 2.1 2.4 1 1 1 2 2 2 0 Coiled-coil domain-containing protein 167 Spc24 PF08286.11 ETO30170.1 - 9.4 6.5 10.5 76 3.6 10.5 2.1 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 Siah-Interact_N PF09032.11 ETO30170.1 - 9.6 6.6 14.2 6.6 7.1 1.1 2.6 2 1 1 3 3 2 0 Siah interacting protein, N terminal SAM_1 PF00536.30 ETO30171.1 - 6.3e-22 77.8 4.6 1.3e-10 41.5 0.4 2.7 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO30171.1 - 1.1e-20 73.5 3.2 6.1e-11 42.3 0.2 2.8 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) Fez1 PF06818.15 ETO30171.1 - 0.0061 17.0 11.3 0.0061 17.0 11.3 4.2 3 1 1 4 4 4 1 Fez1 SAM_Ste50p PF09235.10 ETO30171.1 - 0.026 14.8 0.8 0.56 10.5 0.2 3.0 2 0 0 2 2 2 0 Ste50p, sterile alpha motif DUF3450 PF11932.8 ETO30171.1 - 1.7 7.9 53.5 0.033 13.5 3.3 4.9 4 1 1 5 5 5 0 Protein of unknown function (DUF3450) FUSC PF04632.12 ETO30171.1 - 2.4 6.6 10.5 2.5 6.5 3.8 2.3 2 0 0 2 2 2 0 Fusaric acid resistance protein family DUF745 PF05335.13 ETO30171.1 - 3.9 7.2 42.6 0.041 13.6 16.8 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF745) DUF1664 PF07889.12 ETO30171.1 - 7.7 6.6 41.9 0.61 10.1 9.5 5.6 5 2 2 7 7 7 0 Protein of unknown function (DUF1664) DUF1110 PF06533.12 ETO30171.1 - 9.5 6.1 8.2 2.2 8.2 1.9 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1110) SIR2 PF02146.17 ETO30172.1 - 1.7e-05 24.9 0.5 0.0001 22.3 0.5 2.2 1 1 0 1 1 1 1 Sir2 family DUF1843 PF08898.10 ETO30173.1 - 0.067 13.7 4.8 3.2 8.3 2.5 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1843) YabA PF06156.13 ETO30173.1 - 0.21 12.3 9.4 0.33 11.6 7.8 2.1 2 0 0 2 2 2 0 Initiation control protein YabA USP8_interact PF08941.10 ETO30173.1 - 0.36 10.6 4.8 0.54 10.0 4.8 1.3 1 0 0 1 1 1 0 USP8 interacting Vpu PF00558.19 ETO30173.1 - 2.3 8.1 0.0 2.3 8.1 0.0 2.9 2 1 1 3 3 3 0 Vpu protein V_ATPase_I PF01496.19 ETO30173.1 - 4.5 5.1 9.4 5 4.9 9.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family TMPIT PF07851.13 ETO30173.1 - 4.7 6.4 10.6 6.9 5.8 10.6 1.2 1 0 0 1 1 1 0 TMPIT-like protein CLZ PF16526.5 ETO30173.1 - 5.8 7.3 14.1 11 6.4 11.7 2.4 1 1 1 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Exonuc_VII_L PF02601.15 ETO30173.1 - 6.5 6.2 9.7 7.6 6.0 9.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Sugar_tr PF00083.24 ETO30174.1 - 5.8e-05 22.1 1.0 5.8e-05 22.1 1.0 2.1 1 1 1 2 2 2 2 Sugar (and other) transporter XRN_M PF17846.1 ETO30175.1 - 8.5e-30 104.1 16.7 7.7e-25 87.7 7.7 3.3 1 1 2 3 3 3 3 Xrn1 helical domain Macoilin PF09726.9 ETO30175.1 - 0.0013 17.4 3.6 0.0015 17.2 3.6 1.1 1 0 0 1 1 1 1 Macoilin family Presenilin PF01080.17 ETO30175.1 - 0.007 15.2 5.9 0.0095 14.7 5.9 1.1 1 0 0 1 1 1 1 Presenilin CDC45 PF02724.14 ETO30175.1 - 0.032 12.5 9.3 0.044 12.1 9.3 1.1 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO30175.1 - 0.24 10.6 2.7 0.34 10.1 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ETO30175.1 - 0.97 9.4 8.5 1.9 8.4 8.5 1.5 1 0 0 1 1 1 0 Protein Family FAM60A Mpp10 PF04006.12 ETO30175.1 - 1.4 7.2 23.4 2 6.8 23.4 1.1 1 0 0 1 1 1 0 Mpp10 protein SAE2 PF08573.10 ETO30175.1 - 1.5 9.9 7.0 3.9 8.6 7.0 1.7 1 0 0 1 1 1 0 DNA repair protein endonuclease SAE2/CtIP C-terminus RRN3 PF05327.11 ETO30175.1 - 1.9 6.9 13.4 3.2 6.2 13.4 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Ctr PF04145.15 ETO30175.1 - 2 9.0 4.8 4.3 7.9 4.8 1.5 1 1 0 1 1 1 0 Ctr copper transporter family CSG2 PF16965.5 ETO30175.1 - 3.3 6.5 5.3 5.6 5.8 5.3 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator SLC12 PF03522.15 ETO30175.1 - 4.9 6.1 16.5 6.7 5.6 15.9 1.4 2 0 0 2 2 2 0 Solute carrier family 12 Nop14 PF04147.12 ETO30175.1 - 8.3 4.5 18.7 11 4.1 18.7 1.1 1 0 0 1 1 1 0 Nop14-like family WD40 PF00400.32 ETO30176.1 - 1.7e-60 199.5 19.1 1.9e-09 37.9 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30176.1 - 1.6e-16 60.4 2.0 6.2e-06 26.4 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO30176.1 - 2.1e-14 53.5 4.6 1.3e-05 24.7 0.1 3.5 3 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO30176.1 - 4.6e-13 48.7 2.6 0.073 11.7 0.0 6.5 2 1 5 7 7 7 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO30176.1 - 2.2e-08 33.5 3.0 0.48 9.3 0.0 5.7 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO30176.1 - 0.00019 20.4 11.6 4.5 5.9 0.5 5.4 1 1 3 5 5 5 3 Nup133 N terminal like PALB2_WD40 PF16756.5 ETO30176.1 - 0.00049 19.1 0.8 3.4 6.5 0.0 3.8 1 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO30176.1 - 0.0013 17.3 1.0 0.3 9.6 0.0 2.8 1 1 1 3 3 3 2 Cytochrome D1 heme domain HARP PF07443.13 ETO30176.1 - 0.0028 17.3 0.1 1.7 8.3 0.0 3.9 4 1 1 5 5 5 1 HepA-related protein (HARP) PD40 PF07676.12 ETO30176.1 - 0.43 10.6 2.7 76 3.4 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO30177.1 - 2.2e-54 180.2 14.3 5.2e-11 42.9 0.1 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30177.1 - 1.5e-17 63.6 0.8 0.0012 19.0 0.0 5.0 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30177.1 - 7e-12 44.9 0.6 0.02 13.8 0.0 5.0 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO30177.1 - 1.1e-10 40.8 0.4 0.026 13.2 0.0 4.4 2 1 3 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO30177.1 - 1.3e-08 35.0 0.1 0.0084 16.0 0.0 3.5 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO30177.1 - 2.3e-06 27.2 0.4 0.19 11.0 0.0 3.9 3 1 1 4 4 4 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO30177.1 - 2.6e-05 22.9 1.1 0.29 9.6 0.1 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO30177.1 - 3.6e-05 23.6 6.2 1.4 8.9 0.2 5.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO30177.1 - 0.00032 20.7 0.2 2.5 8.2 0.0 3.6 4 1 0 4 4 4 2 Family of unknown function (DUF5474) SGL PF08450.12 ETO30177.1 - 0.00093 18.8 0.1 0.0092 15.6 0.0 2.5 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Nucleoporin_N PF08801.11 ETO30177.1 - 0.0024 16.7 4.1 0.27 9.9 3.9 3.2 1 1 0 1 1 1 1 Nup133 N terminal like Str_synth PF03088.16 ETO30177.1 - 0.0043 17.1 0.1 5.2 7.3 0.0 4.0 4 1 0 4 4 4 1 Strictosidine synthase Ret2_MD PF18528.1 ETO30177.1 - 0.0091 16.4 0.2 2.9 8.3 0.1 3.0 1 1 1 3 3 3 1 RNA editing 3' terminal uridylyl transferase 2 middle domain nos_propeller PF18764.1 ETO30177.1 - 0.068 13.1 0.0 25 4.9 0.0 3.5 4 0 0 4 4 4 0 Nitrous oxide reductase propeller repeat PQQ PF01011.21 ETO30177.1 - 0.089 12.8 0.0 13 5.9 0.0 3.8 4 0 0 4 4 4 0 PQQ enzyme repeat Ubiquitin_3 PF14836.6 ETO30177.1 - 0.11 12.5 0.2 4.5 7.3 0.0 2.9 2 1 1 3 3 3 0 Ubiquitin-like domain HARP PF07443.13 ETO30177.1 - 0.15 11.7 0.1 2.5 7.8 0.0 2.9 4 0 0 4 4 4 0 HepA-related protein (HARP) Biotin_lipoyl_2 PF13533.6 ETO30177.1 - 0.21 11.5 0.0 0.58 10.0 0.0 1.8 1 0 0 1 1 1 0 Biotin-lipoyl like FKBP_C PF00254.28 ETO30178.1 - 7.2e-24 83.9 0.7 6.1e-23 81.0 0.1 2.7 3 0 0 3 3 3 1 FKBP-type peptidyl-prolyl cis-trans isomerase zf-TRAF PF02176.18 ETO30178.1 - 2.6e-05 24.8 2.6 2.6e-05 24.8 2.6 2.7 2 1 0 2 2 2 1 TRAF-type zinc finger SKA1 PF07160.12 ETO30178.1 - 0.75 9.6 15.8 0.31 10.9 10.6 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 zf-C3HC4_2 PF13923.6 ETO30178.1 - 2.7 7.9 6.3 24 4.9 3.8 3.3 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FKBP_C PF00254.28 ETO30179.1 - 1.5e-26 92.5 0.3 3.7e-26 91.3 0.3 1.7 1 0 0 1 1 1 1 FKBP-type peptidyl-prolyl cis-trans isomerase NPL PF17800.1 ETO30179.1 - 1.5e-06 28.7 0.1 1.5e-06 28.7 0.1 3.1 2 2 0 2 2 2 1 Nucleoplasmin-like domain Dapper PF15268.6 ETO30179.1 - 0.46 9.3 20.6 0.55 9.0 20.6 1.1 1 0 0 1 1 1 0 Dapper SWI-SNF_Ssr4 PF08549.10 ETO30179.1 - 4.9 5.7 22.9 8 5.0 22.9 1.3 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Alba PF01918.21 ETO30180.1 - 4.3e-15 55.3 0.0 8.5e-15 54.3 0.0 1.5 1 0 0 1 1 1 1 Alba Rpp20 PF12328.8 ETO30180.1 - 0.0017 18.4 0.1 0.002 18.1 0.1 1.3 1 0 0 1 1 1 1 Rpp20 subunit of nuclear RNase MRP and P Eaf7 PF07904.13 ETO30180.1 - 0.074 13.4 0.6 0.24 11.8 0.1 1.9 1 1 1 2 2 2 0 Chromatin modification-related protein EAF7 DUF5085 PF16895.5 ETO30181.1 - 0.0027 18.0 0.8 0.0063 16.9 0.4 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF5085) Glyco_hydro_108 PF05838.12 ETO30181.1 - 0.042 14.3 0.1 0.1 13.1 0.0 1.7 2 0 0 2 2 2 0 Glycosyl hydrolase 108 DUF2981 PF11200.8 ETO30183.1 - 1.9 8.1 6.3 2.2 8.0 6.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2981) Dynamin_M PF01031.20 ETO30184.1 - 6.5e-08 32.1 0.9 1.5e-07 31.0 0.9 1.6 1 0 0 1 1 1 1 Dynamin central region GED PF02212.18 ETO30184.1 - 8.6e-07 29.0 2.0 2.3e-06 27.6 2.0 1.8 1 0 0 1 1 1 1 Dynamin GTPase effector domain Dynamin_N PF00350.23 ETO30185.1 - 7.3e-28 97.7 0.2 7.3e-28 97.7 0.2 2.6 2 1 0 2 2 2 1 Dynamin family Dynamin_M PF01031.20 ETO30185.1 - 4e-12 46.0 4.7 4e-12 46.0 4.7 2.7 2 1 1 3 3 3 1 Dynamin central region MMR_HSR1 PF01926.23 ETO30185.1 - 0.00029 20.9 0.4 0.0035 17.4 0.4 2.5 1 1 0 1 1 1 1 50S ribosome-binding GTPase DUF5636 PF18686.1 ETO30185.1 - 0.015 15.5 2.4 0.015 15.5 2.4 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5636) AAA_16 PF13191.6 ETO30185.1 - 0.031 14.7 0.1 2.9 8.2 0.0 2.3 2 0 0 2 2 2 0 AAA ATPase domain Peptidase_M75 PF09375.10 ETO30185.1 - 0.037 13.5 0.4 0.037 13.5 0.4 1.5 2 0 0 2 2 2 0 Imelysin GTP_EFTU PF00009.27 ETO30185.1 - 0.054 13.0 1.9 3.7 7.0 1.6 3.1 1 1 0 1 1 1 0 Elongation factor Tu GTP binding domain LAM_C PF12544.8 ETO30185.1 - 0.1 12.8 0.3 0.1 12.8 0.3 2.3 2 1 0 2 2 2 0 Lysine-2,3-aminomutase ABC_tran PF00005.27 ETO30185.1 - 0.11 13.0 0.1 0.11 13.0 0.1 2.0 2 1 0 2 2 2 0 ABC transporter zinc_ribbon_11 PF11682.8 ETO30185.1 - 0.21 11.6 0.5 1.3 9.1 0.0 2.5 2 1 1 3 3 3 0 Probable zinc-ribbon DUF883 PF05957.13 ETO30185.1 - 0.81 10.3 5.0 4 8.1 0.0 3.1 2 1 2 4 4 4 0 Bacterial protein of unknown function (DUF883) Exonuc_VII_L PF02601.15 ETO30185.1 - 4.9 6.6 7.8 0.18 11.3 2.2 1.5 2 0 0 2 2 2 0 Exonuclease VII, large subunit IMPDH PF00478.25 ETO30186.1 - 1.5e-83 280.7 1.1 1.8e-83 280.4 1.1 1.0 1 0 0 1 1 1 1 IMP dehydrogenase / GMP reductase domain FMN_dh PF01070.18 ETO30186.1 - 0.01 14.9 4.9 0.012 14.7 2.9 1.7 1 1 1 2 2 2 0 FMN-dependent dehydrogenase Aldolase PF01081.19 ETO30186.1 - 0.039 13.4 0.5 0.44 10.0 0.0 2.2 1 1 0 2 2 2 0 KDPG and KHG aldolase ApoO PF09769.9 ETO30187.1 - 0.017 15.1 0.0 0.023 14.6 0.0 1.3 1 0 0 1 1 1 0 Apolipoprotein O DUF948 PF06103.11 ETO30188.1 - 0.011 15.9 0.3 5 7.5 0.0 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF3802 PF12290.8 ETO30188.1 - 0.022 15.3 0.1 0.059 13.9 0.1 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3802) DUF2730 PF10805.8 ETO30188.1 - 0.058 13.5 0.6 5.2 7.2 0.0 2.5 1 1 1 3 3 3 0 Protein of unknown function (DUF2730) RasGEF PF00617.19 ETO30189.1 - 3e-34 118.8 2.7 4.6e-27 95.4 2.2 2.7 2 0 0 2 2 2 2 RasGEF domain SNX17_FERM_C PF18116.1 ETO30189.1 - 0.049 13.7 0.1 0.17 12.0 0.1 1.9 1 0 0 1 1 1 0 Sorting Nexin 17 FERM C-terminal domain AAR2 PF05282.11 ETO30189.1 - 0.21 11.0 7.5 0.18 11.1 0.1 2.7 2 0 0 2 2 2 0 AAR2 protein RasGEF_N PF00618.20 ETO30189.1 - 5.9 7.2 6.9 8.1 6.7 0.1 3.6 3 0 0 3 3 3 0 RasGEF N-terminal motif Secretin_N_2 PF07655.13 ETO30189.1 - 6 7.5 11.6 26 5.4 11.6 2.2 1 0 0 1 1 1 0 Secretin N-terminal domain TPT PF03151.16 ETO30191.1 - 9.7e-07 28.4 2.6 1.1e-06 28.2 2.6 1.1 1 0 0 1 1 1 1 Triose-phosphate Transporter family Imp-YgjV PF10688.9 ETO30191.1 - 0.0011 18.8 0.9 0.0013 18.6 0.9 1.0 1 0 0 1 1 1 1 Bacterial inner membrane protein TSC22 PF01166.18 ETO30192.1 - 1.8 8.9 7.2 0.18 12.2 1.3 2.3 2 0 0 2 2 2 0 TSC-22/dip/bun family PRKG1_interact PF15898.5 ETO30192.1 - 9.4 7.2 11.1 4.5 8.2 3.3 2.9 2 1 1 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF1428 PF07237.11 ETO30193.1 - 0.0029 17.8 0.1 0.007 16.6 0.1 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF1428) FRQ PF09421.10 ETO30194.1 - 0.028 12.5 12.6 0.041 11.9 12.6 1.2 1 0 0 1 1 1 0 Frequency clock protein Peptidase_S64 PF08192.11 ETO30194.1 - 0.51 8.8 11.8 0.68 8.4 11.8 1.1 1 0 0 1 1 1 0 Peptidase family S64 PRR18 PF15671.5 ETO30194.1 - 1.4 8.7 10.4 0.042 13.7 1.2 2.4 3 0 0 3 3 3 0 Proline-rich protein family 18 MAJIN PF15077.6 ETO30194.1 - 4.2 7.1 12.3 6.5 6.5 12.3 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein PA26 PF04636.13 ETO30194.1 - 4.4 6.1 7.5 6 5.7 7.5 1.3 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) BUD22 PF09073.10 ETO30196.1 - 0.00027 20.4 25.2 0.00027 20.4 25.2 3.9 4 1 0 4 4 4 1 BUD22 DUF4746 PF15928.5 ETO30196.1 - 0.0042 16.5 15.4 0.0042 16.5 15.4 4.3 4 1 1 5 5 5 1 Domain of unknown function (DUF4746) DUF1818 PF08848.11 ETO30196.1 - 2 8.5 7.7 5 7.2 0.0 3.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1818) MMR_HSR1 PF01926.23 ETO30197.1 - 3.3e-08 33.6 0.2 1.6e-07 31.4 0.1 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase Dynamin_N PF00350.23 ETO30197.1 - 3.3e-06 27.3 0.1 6.4e-06 26.3 0.1 1.5 1 1 0 1 1 1 1 Dynamin family RsgA_GTPase PF03193.16 ETO30197.1 - 0.01 15.7 0.2 0.6 10.0 0.0 2.4 2 0 0 2 2 2 0 RsgA GTPase Roc PF08477.13 ETO30197.1 - 0.049 13.8 0.0 0.19 11.9 0.0 2.0 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 ETO30197.1 - 0.087 12.3 0.0 0.23 11.0 0.0 1.7 2 0 0 2 2 2 0 Ferrous iron transport protein B AIG1 PF04548.16 ETO30197.1 - 0.18 11.1 1.4 2 7.7 0.1 2.8 3 1 0 3 3 3 0 AIG1 family Consortin_C PF15281.6 ETO30198.1 - 2.1 8.4 5.4 1.2 9.2 0.5 2.0 1 1 1 2 2 2 0 Consortin C-terminus Zip PF02535.22 ETO30199.1 - 0.47 9.6 2.1 0.46 9.6 2.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO30199.1 - 1.1 7.9 6.3 1.1 7.9 6.3 1.2 1 0 0 1 1 1 0 Presenilin PTPRCAP PF15713.5 ETO30199.1 - 7.5 6.8 16.7 0.33 11.2 9.7 1.9 1 1 1 2 2 2 0 Protein tyrosine phosphatase receptor type C-associated DUF3439 PF11921.8 ETO30201.1 - 0.5 10.3 10.3 1.3 9.0 10.3 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) CDC45 PF02724.14 ETO30203.1 - 0.62 8.3 12.3 0.84 7.9 12.3 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2076 PF09849.9 ETO30203.1 - 5.7 6.9 10.8 44 4.0 9.3 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) OTCace PF00185.24 ETO30204.1 - 0.016 15.3 0.5 0.028 14.5 0.5 1.4 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain IZUMO PF15005.6 ETO30204.1 - 0.084 13.4 1.0 0.12 12.9 0.1 1.6 2 0 0 2 2 2 0 Izumo sperm-egg fusion, Ig domain-associated SDA1 PF05285.12 ETO30204.1 - 0.67 9.3 25.0 0.92 8.9 25.0 1.2 1 0 0 1 1 1 0 SDA1 EF-1_beta_acid PF10587.9 ETO30204.1 - 1.5 9.3 0.1 1.5 9.3 0.1 5.2 4 0 0 4 4 4 0 Eukaryotic elongation factor 1 beta central acidic region NUDIX PF00293.28 ETO30205.1 - 3.1e-13 49.9 0.0 3.7e-13 49.6 0.0 1.1 1 0 0 1 1 1 1 NUDIX domain PDEase_I PF00233.19 ETO30206.1 - 6e-26 91.6 0.1 1e-25 90.9 0.1 1.4 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Mucin PF01456.17 ETO30206.1 - 0.03 14.3 0.1 0.051 13.6 0.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein FancD2 PF14631.6 ETO30206.1 - 0.28 8.5 3.6 0.36 8.2 3.6 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Mit_KHE1 PF10173.9 ETO30206.1 - 0.36 10.9 3.8 0.54 10.3 3.8 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related PDEase_I PF00233.19 ETO30207.1 - 1.1e-27 97.3 7.6 1.4e-26 93.7 7.6 2.3 1 1 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase YvbH_ext PF11724.8 ETO30207.1 - 2 8.8 5.0 59 4.1 0.0 3.9 3 1 1 4 4 4 0 YvbH-like oligomerisation region DUF2624 PF11116.8 ETO30208.1 - 0.041 14.8 0.0 0.14 13.1 0.0 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) RPN7 PF10602.9 ETO30209.1 - 3.9e-36 124.4 4.0 7.4e-36 123.5 4.0 1.5 1 0 0 1 1 1 1 26S proteasome subunit RPN7 PCI PF01399.27 ETO30209.1 - 4.9e-17 62.4 2.1 6.8e-17 61.9 0.6 2.0 1 1 1 2 2 2 1 PCI domain Mito_carr PF00153.27 ETO30210.1 - 1.1e-16 60.5 1.4 2e-12 46.9 0.0 3.7 2 1 1 3 3 3 2 Mitochondrial carrier protein ATP-synt_ab_N PF02874.23 ETO30212.1 - 6.3e-06 26.6 0.0 1.7e-05 25.3 0.0 1.7 2 0 0 2 2 2 1 ATP synthase alpha/beta family, beta-barrel domain HAT PF02184.16 ETO30213.1 - 2e-09 37.3 20.0 0.0039 17.1 0.1 6.6 6 1 0 6 6 6 3 HAT (Half-A-TPR) repeat Suf PF05843.14 ETO30213.1 - 3e-08 34.0 7.9 0.00028 21.0 3.0 2.4 1 1 1 2 2 2 2 Suppressor of forked protein (Suf) TPR_14 PF13428.6 ETO30213.1 - 2.1e-05 25.0 0.0 6.2 7.9 0.0 5.1 3 2 3 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO30213.1 - 0.007 16.7 0.1 0.11 12.9 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat MRP-S31 PF15433.6 ETO30213.1 - 0.023 14.4 1.0 0.24 11.0 0.3 2.1 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S31 DUF4874 PF16173.5 ETO30213.1 - 0.083 12.6 0.9 0.51 10.0 0.5 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4874) Pup_ligase PF03136.15 ETO30213.1 - 0.1 11.6 0.0 0.14 11.1 0.0 1.1 1 0 0 1 1 1 0 Pup-ligase protein BSD PF03909.17 ETO30213.1 - 0.78 9.8 5.5 5.6 7.0 3.8 3.1 2 1 1 3 3 3 0 BSD domain HAT PF02184.16 ETO30214.1 - 5e-14 51.9 26.2 0.0003 20.7 0.1 6.5 7 0 0 7 7 7 4 HAT (Half-A-TPR) repeat TPR_14 PF13428.6 ETO30214.1 - 0.00036 21.1 7.2 0.28 12.1 0.0 5.2 6 1 1 7 7 7 2 Tetratricopeptide repeat Suf PF05843.14 ETO30214.1 - 0.0047 16.9 2.5 0.0047 16.9 2.5 3.9 3 2 2 5 5 5 1 Suppressor of forked protein (Suf) TPR_9 PF13371.6 ETO30214.1 - 0.0054 16.8 1.8 0.55 10.4 0.4 2.8 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO30214.1 - 0.0095 16.4 0.1 18 5.9 0.0 3.6 3 1 1 4 4 4 1 Tetratricopeptide repeat U3_assoc_6 PF08640.11 ETO30214.1 - 0.051 13.6 16.1 0.35 11.0 0.9 4.8 3 2 2 5 5 5 0 U3 small nucleolar RNA-associated protein 6 Mad3_BUB1_I PF08311.12 ETO30214.1 - 2.3 8.2 18.5 0.25 11.3 1.0 5.0 3 2 1 4 4 4 0 Mad3/BUB1 homology region 1 TPR_6 PF13174.6 ETO30214.1 - 2.4 9.0 6.2 51 4.8 0.0 4.7 6 0 0 6 6 6 0 Tetratricopeptide repeat NRDE-2 PF08424.10 ETO30214.1 - 2.4 7.2 19.4 2.9 7.0 3.5 4.0 1 1 2 3 3 3 0 NRDE-2, necessary for RNA interference Pkinase PF00069.25 ETO30215.1 - 5.2e-13 49.0 0.9 8.2e-13 48.3 0.9 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO30216.1 - 1.7e-10 40.8 0.0 3e-07 30.1 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain HD_assoc PF13286.6 ETO30217.1 - 0.089 13.3 0.3 0.21 12.2 0.2 1.7 1 1 0 1 1 1 0 Phosphohydrolase-associated domain Complex1_LYR_2 PF13233.6 ETO30217.1 - 1.4 9.7 6.0 2.2 9.1 6.0 1.5 1 1 0 1 1 1 0 Complex1_LYR-like Fis1_TPR_C PF14853.6 ETO30218.1 - 0.00039 20.4 0.8 0.0036 17.3 0.1 2.4 2 0 0 2 2 2 1 Fis1 C-terminal tetratricopeptide repeat TPR_2 PF07719.17 ETO30218.1 - 0.0017 18.3 5.2 0.0035 17.4 0.2 3.3 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO30218.1 - 0.0026 18.0 0.3 0.017 15.4 0.0 2.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30218.1 - 0.0034 17.1 0.6 0.012 15.4 0.6 2.0 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO30218.1 - 0.0035 17.9 0.5 0.46 11.2 0.2 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30218.1 - 0.0035 17.4 2.3 0.01 16.0 0.4 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30218.1 - 0.0083 16.0 0.4 0.043 13.7 0.1 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO30219.1 - 0.16 12.7 0.1 1.8 9.4 0.0 2.3 2 0 0 2 2 2 0 Sel1 repeat Myotub-related PF06602.14 ETO30220.1 - 5.3e-44 150.6 1.8 6e-44 150.4 1.8 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Myotub-related PF06602.14 ETO30221.1 - 6.3e-72 242.4 2.3 1.2e-71 241.6 2.3 1.4 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Ion_trans PF00520.31 ETO30221.1 - 0.14 11.3 2.8 0.25 10.6 0.1 2.2 2 0 0 2 2 2 0 Ion transport protein FtsL PF04999.13 ETO30221.1 - 0.49 10.4 7.5 0.33 11.0 1.7 2.6 2 0 0 2 2 2 0 Cell division protein FtsL TMEMspv1-c74-12 PF11044.8 ETO30221.1 - 0.9 9.6 5.5 1 9.4 0.5 2.6 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Corazonin PF17308.2 ETO30221.1 - 1.5 9.2 27.6 4 7.8 10.7 2.7 2 0 0 2 2 2 0 Pro-corazonin C1_2 PF03107.16 ETO30222.1 - 2.5e-06 27.7 6.9 2.5e-06 27.7 6.9 2.4 2 0 0 2 2 2 1 C1 domain ABC_membrane_2 PF06472.15 ETO30222.1 - 0.016 14.6 0.3 0.016 14.6 0.3 1.7 2 0 0 2 2 2 0 ABC transporter transmembrane region 2 C1_1 PF00130.22 ETO30222.1 - 0.032 14.1 6.0 0.032 14.1 6.0 2.1 2 0 0 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) CTU2 PF10288.9 ETO30222.1 - 0.51 10.6 0.1 0.51 10.6 0.1 2.3 2 1 0 2 2 2 0 Cytoplasmic tRNA 2-thiolation protein 2 RNA_polI_A34 PF08208.11 ETO30224.1 - 0.0042 17.2 13.3 0.0042 17.2 13.3 1.9 1 1 1 2 2 2 1 DNA-directed RNA polymerase I subunit RPA34.5 DMP1 PF07263.11 ETO30224.1 - 0.014 14.4 2.8 0.014 14.4 2.8 2.0 2 0 0 2 2 2 0 Dentin matrix protein 1 (DMP1) GEN1_C PF18380.1 ETO30224.1 - 0.26 12.2 10.3 2 9.3 0.7 2.2 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain MID_MedPIWI PF18296.1 ETO30224.1 - 0.37 10.5 9.1 0.5 10.1 9.1 1.2 1 0 0 1 1 1 0 MID domain of medPIWI Macoilin PF09726.9 ETO30224.1 - 0.42 9.1 17.0 0.48 8.9 17.0 1.0 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 ETO30224.1 - 0.66 8.9 11.3 0.83 8.6 11.3 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PI3K_1B_p101 PF10486.9 ETO30224.1 - 0.71 7.6 12.6 0.87 7.3 12.6 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Presenilin PF01080.17 ETO30224.1 - 1.1 7.9 13.1 1.5 7.5 13.1 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ETO30224.1 - 1.8 8.3 14.2 1.5 8.5 0.3 2.2 2 0 0 2 2 2 0 FAM176 family Glyco_transf_49 PF13896.6 ETO30225.1 - 4.5e-36 124.9 7.7 1.9e-35 122.8 7.7 1.8 1 1 0 1 1 1 1 Glycosyl-transferase for dystroglycan Borrelia_orfX PF04160.12 ETO30225.1 - 0.21 11.6 2.8 1.3 9.1 1.2 2.1 2 0 0 2 2 2 0 Orf-X protein DUF2718 PF10918.8 ETO30226.1 - 2.4 8.7 8.8 0.21 12.1 3.4 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2718) NST1 PF13945.6 ETO30226.1 - 3.2 7.8 10.9 0.59 10.2 5.8 2.0 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF719 PF05334.13 ETO30226.1 - 8.1 6.6 9.4 0.23 11.7 2.8 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF719) zf-C2H2 PF00096.26 ETO30228.1 - 8.3e-05 22.8 9.6 0.0047 17.3 0.1 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ETO30228.1 - 0.0001 22.5 7.5 0.012 15.9 0.2 2.7 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-met PF12874.7 ETO30228.1 - 0.0018 18.6 8.9 0.06 13.7 2.8 2.6 2 0 0 2 2 2 2 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 ETO30228.1 - 0.0039 17.5 6.3 0.13 12.7 1.9 2.8 2 0 0 2 2 2 1 Zinc-finger double domain zf-4CXXC_R1 PF10497.9 ETO30228.1 - 0.008 16.4 4.7 0.011 15.9 4.7 1.4 1 0 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 XPA_N PF01286.18 ETO30228.1 - 0.018 15.1 1.5 0.11 12.6 0.2 2.4 2 0 0 2 2 2 0 XPA protein N-terminal zf-C2H2_4 PF13894.6 ETO30228.1 - 0.038 14.8 13.1 0.064 14.1 0.3 3.1 3 0 0 3 3 2 0 C2H2-type zinc finger CxC5 PF18718.1 ETO30228.1 - 0.039 14.0 6.2 1.3 9.1 2.4 2.2 1 1 1 2 2 2 0 CxC5 like cysteine cluster associated with KDZ transposases C1_4 PF07975.12 ETO30228.1 - 0.044 14.0 3.0 0.044 14.0 3.0 2.2 1 1 1 2 2 2 0 TFIIH C1-like domain Rsc14 PF08586.10 ETO30228.1 - 0.67 10.8 9.8 0.24 12.2 1.1 2.1 2 0 0 2 2 2 0 RSC complex, Rsc14/Ldb7 subunit zf_C2H2_ZHX PF18387.1 ETO30228.1 - 1.8 8.3 12.7 0.27 10.9 1.2 3.1 2 2 2 4 4 4 0 Zinc-fingers and homeoboxes C2H2 finger domain CpXC PF14353.6 ETO30228.1 - 2.1 8.4 8.2 2.7 8.1 4.1 2.5 1 1 2 3 3 3 0 CpXC protein Auxin_canalis PF05703.11 ETO30228.1 - 5.5 6.8 7.1 6.7 6.6 7.1 1.1 1 0 0 1 1 1 0 Auxin canalisation Ctr PF04145.15 ETO30228.1 - 7 7.3 6.2 23 5.6 6.2 1.8 1 1 0 1 1 1 0 Ctr copper transporter family SNF2_N PF00176.23 ETO30229.1 - 2e-23 82.7 0.6 5.6e-22 77.9 0.6 2.7 1 1 0 1 1 1 1 SNF2 family N-terminal domain ResIII PF04851.15 ETO30229.1 - 5.4e-11 42.8 0.0 5.4e-11 42.8 0.0 1.9 2 1 0 2 2 2 1 Type III restriction enzyme, res subunit FapA PF03961.13 ETO30230.1 - 0.12 11.0 1.5 0.15 10.7 1.5 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A RICTOR_V PF14668.6 ETO30231.1 - 5.6e-26 90.6 0.8 1.2e-22 79.9 0.1 4.2 4 0 0 4 4 4 1 Rapamycin-insensitive companion of mTOR, domain 5 RasGEF_N_2 PF14663.6 ETO30231.1 - 1.2e-20 73.9 0.8 1.1e-19 70.8 0.6 2.8 3 0 0 3 3 3 1 Rapamycin-insensitive companion of mTOR RasGEF_N domain RICTOR_M PF14666.6 ETO30231.1 - 2.1e-12 46.7 4.1 2.1e-10 40.3 0.2 4.6 5 0 0 5 5 5 1 Rapamycin-insensitive companion of mTOR, middle domain BLOC1_2 PF10046.9 ETO30232.1 - 3.6 8.0 14.9 1.6 9.1 1.0 3.9 4 0 0 4 4 4 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 CAP_GLY PF01302.25 ETO30233.1 - 1.3e-42 143.7 18.8 1.3e-17 63.6 0.3 5.0 5 0 0 5 5 5 4 CAP-Gly domain YajC PF02699.15 ETO30233.1 - 0.0024 17.7 5.3 0.059 13.3 0.2 3.5 3 0 0 3 3 3 2 Preprotein translocase subunit CAP_GLY PF01302.25 ETO30234.1 - 8.4e-41 137.8 12.7 4.5e-14 52.2 0.1 4.3 4 0 0 4 4 4 4 CAP-Gly domain CAP_GLY PF01302.25 ETO30235.1 - 1.4e-36 124.3 9.7 3e-13 49.6 0.3 3.6 4 0 0 4 4 4 3 CAP-Gly domain SspB PF04386.13 ETO30235.1 - 0.14 12.0 1.9 0.27 11.1 1.9 1.4 1 0 0 1 1 1 0 Stringent starvation protein B YajC PF02699.15 ETO30235.1 - 0.25 11.2 11.5 3.6 7.5 0.0 4.5 5 0 0 5 5 5 0 Preprotein translocase subunit CAP_GLY PF01302.25 ETO30236.1 - 6.2e-159 516.2 56.3 5e-19 68.1 0.2 11.3 11 0 0 11 11 11 11 CAP-Gly domain CooC_C PF15976.5 ETO30236.1 - 0.062 13.3 0.0 0.4 10.8 0.0 2.4 1 0 0 1 1 1 0 CS1-pili formation C-terminal SH3_13 PF18335.1 ETO30236.1 - 0.12 12.3 1.1 1.6 8.6 0.1 3.6 4 0 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain Phage_holin_2_2 PF10746.9 ETO30236.1 - 0.46 10.2 2.2 58 3.5 0.1 3.6 3 0 0 3 3 3 0 Phage holin T7 family, holin superfamily II YajC PF02699.15 ETO30236.1 - 2.7 7.9 18.7 13 5.8 0.1 7.2 8 0 0 8 8 8 0 Preprotein translocase subunit Pkinase PF00069.25 ETO30237.1 - 1.6e-27 96.5 3.3 5.8e-27 94.7 3.3 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO30237.1 - 0.00027 19.8 0.0 0.00027 19.8 0.0 2.4 2 1 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 ETO30237.1 - 0.016 14.8 0.0 0.016 14.8 0.0 2.4 3 0 0 3 3 3 0 Choline/ethanolamine kinase ERM PF00769.19 ETO30238.1 - 3.8e-06 26.9 22.3 5.6e-06 26.4 22.3 1.3 1 0 0 1 1 1 1 Ezrin/radixin/moesin family CENP-F_leu_zip PF10473.9 ETO30238.1 - 0.0026 17.8 19.4 0.0026 17.8 19.4 2.3 1 1 0 2 2 2 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc29 PF17082.5 ETO30238.1 - 0.11 12.4 21.5 0.019 14.8 9.0 2.1 1 1 1 2 2 2 0 Spindle Pole Component 29 Exonuc_VII_L PF02601.15 ETO30238.1 - 0.18 11.4 22.3 0.25 10.9 22.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit FTZ PF03867.14 ETO30238.1 - 0.58 9.6 5.4 0.79 9.2 5.4 1.3 1 0 0 1 1 1 0 Fushi tarazu (FTZ), N-terminal region DHR10 PF18595.1 ETO30238.1 - 0.92 9.6 34.5 1.3 9.1 10.6 2.7 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain HrpB7 PF09486.10 ETO30238.1 - 3.4 8.1 16.0 1.5 9.2 6.2 2.4 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) DUF3800 PF12686.7 ETO30238.1 - 4.5 7.9 5.9 13 6.4 5.9 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) FUSC PF04632.12 ETO30238.1 - 5.8 5.3 6.0 7.5 5.0 6.0 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family UPF0172 PF03665.13 ETO30238.1 - 8.1 6.4 12.0 2.8 8.0 9.4 1.6 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0172) DUF2457 PF10446.9 ETO30239.1 - 8.6 5.4 29.2 1.5 7.9 12.6 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF2457) Gpr1_Fun34_YaaH PF01184.19 ETO30240.1 - 0.44 10.1 7.6 0.65 9.6 7.6 1.2 1 0 0 1 1 1 0 GPR1/FUN34/yaaH family TGS PF02824.21 ETO30241.1 - 1.2e-10 41.3 0.0 1.8e-10 40.7 0.0 1.3 1 0 0 1 1 1 1 TGS domain SM-ATX PF14438.6 ETO30241.1 - 0.07 13.3 0.0 0.11 12.7 0.0 1.3 1 0 0 1 1 1 0 Ataxin 2 SM domain DSPc PF00782.20 ETO30242.1 - 1.6e-09 37.7 0.1 6.1e-09 35.8 0.1 2.1 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain DUF2439 PF10382.9 ETO30242.1 - 0.037 14.3 0.2 0.037 14.3 0.2 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF2439) Kelch_2 PF07646.15 ETO30245.1 - 0.00063 19.6 2.7 7.2 6.8 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO30245.1 - 0.00065 19.9 4.9 1.1 9.6 0.1 4.9 4 1 1 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO30245.1 - 0.0013 18.7 0.4 0.57 10.2 0.0 3.8 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO30245.1 - 0.0075 16.2 0.7 0.2 11.7 0.0 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO30245.1 - 0.0092 15.5 0.8 13 5.4 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Sec66 PF09802.9 ETO30248.1 - 0.042 13.4 0.0 0.073 12.6 0.0 1.4 1 0 0 1 1 1 0 Preprotein translocase subunit Sec66 DDOST_48kD PF03345.14 ETO30249.1 - 1.9e-23 83.0 1.3 9.2e-20 70.9 1.4 2.1 1 1 1 2 2 2 2 Oligosaccharyltransferase 48 kDa subunit beta IL6 PF00489.17 ETO30249.1 - 0.011 15.3 0.4 0.02 14.5 0.4 1.3 1 0 0 1 1 1 0 Interleukin-6/G-CSF/MGF family DUF4329 PF14220.6 ETO30249.1 - 0.033 14.2 0.1 0.051 13.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4329) NADH-UOR_E PF16514.5 ETO30249.1 - 0.056 13.8 0.0 0.15 12.4 0.0 1.8 1 0 0 1 1 1 0 putative NADH-ubiquinone oxidoreductase chain E MAPEG PF01124.18 ETO30250.1 - 5.4e-05 23.1 0.2 6.8e-05 22.8 0.2 1.1 1 0 0 1 1 1 1 MAPEG family DUF3446 PF11928.8 ETO30252.1 - 1.2 9.5 9.9 2.2 8.6 1.4 2.8 3 0 0 3 3 3 0 Early growth response N-terminal domain SR-25 PF10500.9 ETO30252.1 - 3.7 7.1 10.8 7.4 6.1 0.2 2.2 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein DGF-1_4 PF11024.8 ETO30253.1 - 0.1 13.4 3.2 0.19 12.5 3.2 1.4 1 0 0 1 1 1 0 Dispersed gene family protein 1 of Trypanosoma cruzi region 4 eIF-3_zeta PF05091.12 ETO30254.1 - 2.8e-32 112.4 0.4 5.4e-31 108.2 0.4 1.9 1 1 0 1 1 1 1 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) INCENP_ARK-bind PF03941.15 ETO30255.1 - 4e-12 45.9 0.2 7.6e-12 45.0 0.2 1.4 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region DUF4898 PF16239.5 ETO30256.1 - 0.00029 20.7 1.2 0.00092 19.1 1.2 1.8 1 0 0 1 1 1 1 Domain of unknown function (DUF4898) NAD_Gly3P_dh_N PF01210.23 ETO30256.1 - 0.011 15.8 2.4 2.3 8.2 0.6 2.6 2 0 0 2 2 2 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus Corazonin PF17308.2 ETO30257.1 - 1.1 9.6 11.5 2 8.8 7.5 2.3 2 0 0 2 2 2 0 Pro-corazonin Chi-conotoxin PF16981.5 ETO30257.1 - 1.9 8.8 4.1 1 9.7 0.1 2.5 3 0 0 3 3 3 0 chi-Conotoxin or t superfamily PUF PF00806.19 ETO30258.1 - 3.8e-39 130.2 15.3 1.3e-05 24.6 0.0 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat DUF2389 PF09493.10 ETO30259.1 - 0.0052 17.4 0.1 0.02 15.5 0.0 2.1 2 0 0 2 2 2 1 Tryptophan-rich protein (DUF2389) Zip PF02535.22 ETO30261.1 - 5.6e-08 32.4 4.6 5.6e-08 32.4 4.6 3.6 1 1 2 3 3 3 2 ZIP Zinc transporter DUF5381 PF17353.2 ETO30261.1 - 0.31 10.8 1.8 0.74 9.5 1.8 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5381) Peptidase_S64 PF08192.11 ETO30263.1 - 0.76 8.2 27.4 1.1 7.7 27.4 1.1 1 0 0 1 1 1 0 Peptidase family S64 NOA36 PF06524.12 ETO30263.1 - 1.3 8.3 17.7 0.8 9.0 11.8 2.1 2 0 0 2 2 2 0 NOA36 protein IR1-M PF12185.8 ETO30264.1 - 0.12 12.3 0.2 0.3 11.1 0.2 1.7 1 0 0 1 1 1 0 Nup358/RanBP2 E3 ligase domain VASt PF16016.5 ETO30265.1 - 2.6e-14 53.9 9.0 0.00013 22.4 0.2 4.1 3 1 1 4 4 4 3 VAD1 Analog of StAR-related lipid transfer domain DUF1057 PF06342.12 ETO30266.1 - 0.047 12.7 0.1 0.058 12.4 0.1 1.1 1 0 0 1 1 1 0 Alpha/beta hydrolase of unknown function (DUF1057) IQ_SEC7_PH PF16453.5 ETO30267.1 - 0.0035 17.3 0.1 0.0065 16.4 0.1 1.5 1 0 0 1 1 1 1 PH domain Folliculin PF11704.8 ETO30267.1 - 0.074 12.9 0.6 0.12 12.3 0.6 1.4 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4675 PF15720.5 ETO30267.1 - 0.13 12.0 2.8 0.09 12.6 1.1 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4675) ResIII PF04851.15 ETO30267.1 - 0.45 10.5 5.1 4.3 7.3 0.3 2.1 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit PT PF04886.12 ETO30268.1 - 0.25 10.9 7.7 0.56 9.8 7.7 1.5 1 0 0 1 1 1 0 PT repeat DBD_Tnp_Hermes PF10683.9 ETO30269.1 - 0.027 14.2 0.0 1.9 8.3 0.0 2.5 2 0 0 2 2 2 0 Hermes transposase DNA-binding domain DUF5564 PF17719.1 ETO30271.1 - 0.32 11.1 1.8 0.54 10.4 0.1 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5564) zf-TRAF PF02176.18 ETO30273.1 - 2e-05 25.2 3.8 2e-05 25.2 3.8 2.9 2 0 0 2 2 2 1 TRAF-type zinc finger Phage_HK97_TLTM PF06120.11 ETO30273.1 - 0.13 11.4 5.5 0.27 10.4 5.5 1.5 1 0 0 1 1 1 0 Tail length tape measure protein FapA PF03961.13 ETO30273.1 - 0.46 9.0 6.4 0.79 8.3 6.4 1.3 1 0 0 1 1 1 0 Flagellar Assembly Protein A V_ATPase_I PF01496.19 ETO30273.1 - 0.5 8.2 7.7 0.91 7.4 7.7 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family SAMP PF05924.11 ETO30273.1 - 0.58 9.5 2.1 2.1 7.7 2.1 2.0 1 0 0 1 1 1 0 SAMP Motif LPD1 PF18796.1 ETO30274.1 - 0.0015 18.6 1.5 0.0022 18.1 1.5 1.2 1 0 0 1 1 1 1 Large polyvalent protein-associated domain 1 Glyco_hydro_18 PF00704.28 ETO30276.1 - 2.8e-09 37.2 0.0 3.2e-09 36.9 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 18 Bee_toxin PF17454.2 ETO30276.1 - 0.019 15.0 1.0 0.019 15.0 1.0 2.7 3 0 0 3 3 3 0 Honey bee toxin UCH PF00443.29 ETO30280.1 - 1.2e-20 74.1 3.9 1.4e-20 73.9 0.2 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO30280.1 - 8e-08 32.2 0.0 8e-08 32.2 0.0 2.1 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase AIG1 PF04548.16 ETO30281.1 - 5.4e-13 48.8 0.0 5.4e-13 48.8 0.0 2.3 2 1 1 3 3 3 1 AIG1 family MMR_HSR1 PF01926.23 ETO30281.1 - 0.014 15.4 0.0 0.034 14.2 0.0 1.6 1 0 0 1 1 1 0 50S ribosome-binding GTPase cobW PF02492.19 ETO30281.1 - 0.086 12.4 0.0 0.16 11.5 0.0 1.5 1 0 0 1 1 1 0 CobW/HypB/UreG, nucleotide-binding domain MMR_HSR1_Xtn PF16897.5 ETO30281.1 - 0.28 11.2 2.4 1.3 9.1 0.1 2.4 2 0 0 2 2 2 0 C-terminal region of MMR_HSR1 domain SpoU_methylase PF00588.19 ETO30283.1 - 1.1e-24 87.2 0.0 1.3e-24 86.9 0.0 1.0 1 0 0 1 1 1 1 SpoU rRNA Methylase family SPOUT_MTase_2 PF14419.6 ETO30283.1 - 0.045 13.1 0.0 0.084 12.2 0.0 1.5 1 1 0 1 1 1 0 AF2226-like SPOUT RNA Methylase fused to THUMP FGF-BP1 PF06473.12 ETO30284.1 - 0.2 11.5 7.1 0.5 10.2 7.1 1.6 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) AIG1 PF04548.16 ETO30285.1 - 1.8e-18 66.6 0.0 1.8e-18 66.6 0.0 2.2 2 1 1 3 3 3 1 AIG1 family MMR_HSR1 PF01926.23 ETO30285.1 - 1.1e-05 25.5 0.6 5.4e-05 23.2 0.0 2.5 1 1 1 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO30285.1 - 8.8e-05 22.5 0.9 0.0016 18.4 0.0 2.7 2 0 0 2 2 2 1 RsgA GTPase GTP_EFTU PF00009.27 ETO30285.1 - 0.011 15.3 3.5 0.074 12.6 0.0 3.1 3 0 0 3 3 3 0 Elongation factor Tu GTP binding domain Mg_chelatase PF01078.21 ETO30285.1 - 0.1 12.0 0.1 2.4 7.5 0.0 2.6 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI V_ATPase_I PF01496.19 ETO30285.1 - 0.59 8.0 21.3 1.8 6.4 15.1 2.2 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family TMCO5 PF14992.6 ETO30285.1 - 0.6 9.6 29.8 0.2 11.2 22.7 2.2 2 0 0 2 2 2 0 TMCO5 family Peptidase_S46 PF10459.9 ETO30285.1 - 1.7 7.2 18.2 2.5 6.6 18.2 1.3 1 0 0 1 1 1 0 Peptidase S46 Fcf1 PF04900.12 ETO30285.1 - 2.4 8.6 5.6 4.6 7.7 1.0 2.7 2 0 0 2 2 2 0 Fcf1 GCP_C_terminal PF04130.13 ETO30286.1 - 2.9e-52 178.1 3.6 4.2e-52 177.5 3.6 1.2 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal GCP_N_terminal PF17681.1 ETO30286.1 - 6.3e-06 26.0 0.0 1.3e-05 25.0 0.0 1.5 1 0 0 1 1 1 1 Gamma tubulin complex component N-terminal Amidinotransf PF02274.17 ETO30287.1 - 0.0059 15.7 0.0 1.5 7.9 0.0 2.8 2 2 1 3 3 3 2 Amidinotransferase DUF2457 PF10446.9 ETO30288.1 - 0.0045 16.2 27.4 0.0045 16.2 27.4 2.6 1 1 2 3 3 3 1 Protein of unknown function (DUF2457) Merozoite_SPAM PF07133.11 ETO30288.1 - 0.0059 16.6 60.8 0.0059 16.6 60.8 2.0 2 0 0 2 2 2 1 Merozoite surface protein (SPAM) ResB PF05140.14 ETO30288.1 - 0.019 13.7 6.0 0.021 13.6 6.0 1.1 1 0 0 1 1 1 0 ResB-like family TFIIF_alpha PF05793.12 ETO30288.1 - 0.045 12.4 59.8 0.065 11.8 59.8 1.2 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SOBP PF15279.6 ETO30288.1 - 1.5 9.4 14.0 2.4 8.7 14.0 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein CDC45 PF02724.14 ETO30289.1 - 1.8e-07 29.9 11.3 2.3e-07 29.5 11.3 1.0 1 0 0 1 1 1 1 CDC45-like protein Nucleo_P87 PF07267.11 ETO30289.1 - 0.069 12.0 7.4 0.088 11.7 7.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Nop14 PF04147.12 ETO30289.1 - 7.3 4.7 16.4 8.7 4.4 16.4 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO30290.1 - 1.2e-51 175.8 0.2 1.6e-51 175.4 0.2 1.0 1 0 0 1 1 1 1 CDC45-like protein GMC_oxred_C PF05199.13 ETO30291.1 - 8.1e-28 97.8 0.3 1.2e-26 94.0 0.3 2.1 1 1 0 1 1 1 1 GMC oxidoreductase AA_permease PF00324.21 ETO30292.1 - 3.2e-43 148.0 27.9 4.4e-43 147.6 27.9 1.3 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETO30292.1 - 1.6e-17 63.5 30.3 2.2e-17 63.1 30.3 1.1 1 0 0 1 1 1 1 Amino acid permease Fez1 PF06818.15 ETO30293.1 - 0.0055 17.2 18.2 0.0055 17.2 18.2 4.1 1 1 3 4 4 4 2 Fez1 TrkA_N PF02254.18 ETO30293.1 - 0.0089 16.3 3.7 0.011 16.0 1.5 2.2 2 0 0 2 2 2 1 TrkA-N domain ERM PF00769.19 ETO30293.1 - 0.22 11.3 62.3 0.41 10.4 24.6 3.1 3 0 0 3 3 3 0 Ezrin/radixin/moesin family HSP20 PF00011.21 ETO30294.1 - 1.4e-13 50.9 0.1 1.4e-13 50.9 0.1 2.4 2 1 0 2 2 2 1 Hsp20/alpha crystallin family SRP19 PF01922.17 ETO30294.1 - 0.00057 20.8 5.1 0.0014 19.5 5.1 1.7 1 0 0 1 1 1 1 SRP19 protein ArsA_HSP20 PF17886.1 ETO30294.1 - 0.018 14.6 0.0 0.032 13.8 0.0 1.5 1 0 0 1 1 1 0 HSP20-like domain found in ArsA Consortin_C PF15281.6 ETO30294.1 - 0.59 10.1 0.1 0.59 10.1 0.1 3.1 1 1 2 3 3 3 0 Consortin C-terminus Dev_Cell_Death PF10539.9 ETO30298.1 - 1.3e-18 67.1 0.0 3e-18 65.9 0.0 1.6 1 0 0 1 1 1 1 Development and cell death domain Comm PF15957.5 ETO30298.1 - 0.46 10.8 2.4 1.2 9.5 0.0 3.0 2 0 0 2 2 2 0 Commissureless Flp_N PF03930.14 ETO30299.1 - 0.005 16.8 0.3 0.012 15.5 0.3 1.6 1 0 0 1 1 1 1 Recombinase Flp protein N-terminus Novirhabdo_Nv PF05554.11 ETO30301.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Viral hemorrhagic septicemia virus non-virion protein RNA_pol_3_Rpc31 PF11705.8 ETO30302.1 - 0.013 15.7 14.8 0.013 15.7 14.8 3.9 1 1 2 3 3 3 0 DNA-directed RNA polymerase III subunit Rpc31 AI-2E_transport PF01594.16 ETO30302.1 - 0.3 10.2 1.6 1.8 7.7 1.6 2.0 1 1 0 1 1 1 0 AI-2E family transporter Goodbye PF17109.5 ETO30302.1 - 0.34 11.4 0.1 0.34 11.4 0.1 4.4 3 1 2 5 5 5 0 fungal STAND N-terminal Goodbye domain FAST_2 PF08368.12 ETO30302.1 - 6.5 7.6 8.1 39 5.1 0.1 2.6 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 2 EMP70 PF02990.16 ETO30303.1 - 1.9e-56 191.8 24.3 2.5e-56 191.4 24.3 1.1 1 0 0 1 1 1 1 Endomembrane protein 70 PMSR PF01625.21 ETO30304.1 - 6.2e-44 149.9 8.7 3.2e-42 144.3 8.7 2.8 1 1 0 1 1 1 1 Peptide methionine sulfoxide reductase CENP-F_N PF10481.9 ETO30304.1 - 0.028 14.1 0.8 0.042 13.5 0.8 1.2 1 0 0 1 1 1 0 Cenp-F N-terminal domain Mob1_phocein PF03637.17 ETO30305.1 - 3.1e-27 95.7 11.6 1.4e-25 90.3 11.6 2.2 1 1 0 1 1 1 1 Mob1/phocein family Zn_ribbon_recom PF13408.6 ETO30305.1 - 0.23 12.0 4.4 3.1 8.4 1.0 2.5 2 0 0 2 2 2 0 Recombinase zinc beta ribbon domain Ank_2 PF12796.7 ETO30306.1 - 4.1e-26 91.4 2.5 3.7e-12 46.7 0.2 3.3 1 1 2 3 3 3 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO30306.1 - 9.1e-20 70.8 0.6 1.1e-07 32.3 0.0 4.5 2 1 3 5 5 5 4 Ankyrin repeats (many copies) Ank PF00023.30 ETO30306.1 - 1.1e-19 70.0 1.4 0.0015 18.9 0.3 5.6 5 0 0 5 5 5 5 Ankyrin repeat Ank_5 PF13857.6 ETO30306.1 - 7.9e-19 67.5 1.2 3e-06 27.4 0.0 4.4 3 1 1 4 4 4 3 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO30306.1 - 1.8e-18 64.7 1.3 0.0036 17.7 0.0 6.1 6 0 0 6 6 6 4 Ankyrin repeat SH3_1 PF00018.28 ETO30306.1 - 0.052 13.2 0.0 0.15 11.7 0.0 1.8 1 0 0 1 1 1 0 SH3 domain Mito_carr PF00153.27 ETO30307.1 - 8.1e-40 134.7 0.8 2e-19 69.3 0.3 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein PP2C PF00481.21 ETO30309.1 - 1.8e-40 139.2 0.2 4.8e-29 101.8 0.0 2.2 2 0 0 2 2 2 2 Protein phosphatase 2C SpoIIE PF07228.12 ETO30309.1 - 1.1e-05 25.4 0.0 0.028 14.3 0.0 2.4 2 0 0 2 2 2 2 Stage II sporulation protein E (SpoIIE) PP2C_2 PF13672.6 ETO30309.1 - 0.012 15.3 0.0 0.038 13.6 0.0 1.7 2 0 0 2 2 2 0 Protein phosphatase 2C Metallophos PF00149.28 ETO30311.1 - 1.2e-05 25.9 0.9 3.8e-05 24.3 0.7 1.9 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_C PF14008.6 ETO30311.1 - 8e-05 23.4 0.6 0.00024 21.9 0.6 1.9 1 0 0 1 1 1 1 Iron/zinc purple acid phosphatase-like protein C Adeno_knob PF00541.17 ETO30312.1 - 0.0044 16.8 1.2 0.0044 16.8 1.2 1.9 2 0 0 2 2 2 1 Adenoviral fibre protein (knob domain) SDA1 PF05285.12 ETO30312.1 - 0.95 8.8 30.4 1.4 8.3 9.0 2.3 2 0 0 2 2 2 0 SDA1 DUF5308 PF17233.2 ETO30312.1 - 1.5 9.1 9.9 8.3 6.6 0.7 2.9 2 1 0 2 2 2 0 Family of unknown function (DUF5308) SURF2 PF05477.11 ETO30312.1 - 4 7.1 25.5 1.9 8.1 7.4 2.4 2 0 0 2 2 2 0 Surfeit locus protein 2 (SURF2) Sporozoite_P67 PF05642.11 ETO30313.1 - 0.011 13.8 11.6 0.017 13.2 11.6 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Abhydrolase_2 PF02230.16 ETO30314.1 - 1.9e-05 24.6 0.0 2.9e-05 24.0 0.0 1.2 1 0 0 1 1 1 1 Phospholipase/Carboxylesterase Esterase PF00756.20 ETO30314.1 - 0.1 12.2 0.0 0.14 11.8 0.0 1.1 1 0 0 1 1 1 0 Putative esterase Hydrolase_4 PF12146.8 ETO30314.1 - 0.2 10.9 0.0 1.5 8.1 0.0 1.9 1 1 1 2 2 2 0 Serine aminopeptidase, S33 Vps39_1 PF10366.9 ETO30315.1 - 0.82 10.0 4.9 2.1 8.7 0.3 3.0 3 0 0 3 3 3 0 Vacuolar sorting protein 39 domain 1 Presenilin PF01080.17 ETO30315.1 - 2.1 7.0 7.8 3.2 6.4 7.8 1.2 1 0 0 1 1 1 0 Presenilin COX5A PF02284.16 ETO30316.1 - 0.1 12.6 0.0 0.2 11.7 0.0 1.5 1 0 0 1 1 1 0 Cytochrome c oxidase subunit Va DUF3484 PF11983.8 ETO30317.1 - 0.12 13.5 0.2 0.12 13.5 0.2 3.1 4 0 0 4 4 4 0 Membrane-attachment and polymerisation-promoting switch Pkinase PF00069.25 ETO30318.1 - 0.00015 21.2 0.0 0.00015 21.2 0.0 1.0 1 0 0 1 1 1 1 Protein kinase domain ABC1 PF03109.16 ETO30318.1 - 0.013 15.7 0.0 0.017 15.3 0.0 1.2 1 0 0 1 1 1 0 ABC1 family Pkinase_Tyr PF07714.17 ETO30318.1 - 0.03 13.6 0.0 0.03 13.6 0.0 1.1 1 0 0 1 1 1 0 Protein tyrosine kinase adh_short PF00106.25 ETO30319.1 - 1e-16 61.0 0.2 1.3e-16 60.7 0.2 1.1 1 0 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO30319.1 - 7.3e-13 48.8 0.0 9.4e-13 48.5 0.0 1.1 1 0 0 1 1 1 1 KR domain adh_short_C2 PF13561.6 ETO30319.1 - 5.9e-09 35.8 0.0 7.6e-09 35.5 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase Polysacc_synt_2 PF02719.15 ETO30319.1 - 1e-06 28.2 1.8 1.4e-06 27.7 1.8 1.2 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein NAD_binding_4 PF07993.12 ETO30319.1 - 0.0036 16.5 0.1 0.0065 15.7 0.1 1.6 1 1 0 1 1 1 1 Male sterility protein 3Beta_HSD PF01073.19 ETO30319.1 - 0.014 14.4 0.8 0.018 14.1 0.8 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO30319.1 - 0.039 13.4 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 NAD dependent epimerase/dehydratase family DUF5638 PF18688.1 ETO30319.1 - 0.043 14.1 5.7 0.085 13.2 5.7 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5638) Cas_Cas02710 PF09670.10 ETO30319.1 - 0.055 12.3 0.8 0.22 10.3 0.5 1.8 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas02710) Acetyltransf_3 PF13302.7 ETO30320.1 - 6.3e-11 43.1 0.0 7.4e-11 42.9 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_4 PF13420.7 ETO30320.1 - 2.6e-07 30.9 0.2 3e-07 30.7 0.2 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_1 PF00583.25 ETO30320.1 - 1.5e-05 25.2 0.0 1.8e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family FR47 PF08445.10 ETO30320.1 - 5.1e-05 23.2 0.0 7.1e-05 22.7 0.0 1.2 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_8 PF13523.6 ETO30320.1 - 0.0086 15.8 0.0 0.011 15.5 0.0 1.1 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO30320.1 - 0.035 14.0 0.0 0.055 13.4 0.0 1.3 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain HMG_box PF00505.19 ETO30321.1 - 0.012 16.0 0.7 0.019 15.4 0.7 1.4 1 0 0 1 1 1 0 HMG (high mobility group) box U1snRNP70_N PF12220.8 ETO30321.1 - 1.1 10.0 7.3 1.6 9.5 7.3 1.5 1 1 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Sigma70_ner PF04546.13 ETO30322.1 - 2.3 8.0 6.1 1.8 8.4 3.8 1.9 2 0 0 2 2 2 0 Sigma-70, non-essential region Kelch_2 PF07646.15 ETO30323.1 - 7.6e-08 32.0 1.6 0.043 13.8 0.0 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO30323.1 - 0.00054 20.1 2.5 2.7 8.4 0.0 4.2 3 2 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO30323.1 - 0.00075 19.0 0.8 0.21 11.2 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO30323.1 - 0.033 14.2 3.2 4 7.5 0.0 4.1 5 1 0 5 5 5 0 Kelch motif Kelch_4 PF13418.6 ETO30323.1 - 0.044 13.8 0.0 0.22 11.5 0.0 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain EF-hand_7 PF13499.6 ETO30324.1 - 4.7e-12 46.2 2.1 2.3e-07 31.1 0.1 2.2 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO30324.1 - 6.7e-07 28.8 0.1 0.0002 21.1 0.2 2.5 2 0 0 2 2 2 1 EF-hand domain EF-hand_1 PF00036.32 ETO30324.1 - 1.1e-05 24.6 0.0 0.0043 16.5 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 ETO30324.1 - 0.0018 18.1 0.5 0.081 12.8 0.6 2.3 2 0 0 2 2 2 1 EF hand SPARC_Ca_bdg PF10591.9 ETO30324.1 - 0.026 14.8 0.6 0.22 11.9 0.4 2.1 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 ETO30324.1 - 0.05 13.5 0.0 8.1 6.4 0.1 2.4 2 0 0 2 2 2 0 EF-hand domain pair DUF2205 PF10224.9 ETO30324.1 - 0.054 13.5 1.5 15 5.7 0.9 2.8 2 1 1 3 3 3 0 Short coiled-coil protein BCNT PF07572.12 ETO30324.1 - 0.055 13.5 0.2 3.6 7.7 0.4 2.5 2 0 0 2 2 2 0 Bucentaur or craniofacial development DUF3514 PF12027.8 ETO30325.1 - 0.02 14.6 0.1 0.054 13.2 0.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3514) 2-Hacid_dh PF00389.30 ETO30325.1 - 0.06 13.0 0.0 0.18 11.5 0.0 1.7 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain APOBEC_C PF05240.14 ETO30325.1 - 0.078 12.9 0.9 0.28 11.1 0.2 2.5 2 0 0 2 2 2 0 APOBEC-like C-terminal domain tRNA_lig_kinase PF08303.11 ETO30326.1 - 0.036 14.1 0.5 0.051 13.7 0.5 1.5 1 1 0 1 1 1 0 tRNA ligase kinase domain DUF294_C PF10335.9 ETO30327.1 - 0.22 11.3 1.6 4.7 7.0 1.0 3.0 2 1 0 2 2 2 0 Putative nucleotidyltransferase substrate binding domain Ank_4 PF13637.6 ETO30328.1 - 6.5e-13 48.9 0.4 7.9e-09 35.9 0.2 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO30328.1 - 2.7e-10 40.7 0.5 3.2e-08 34.0 0.1 2.4 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO30328.1 - 8.4e-09 35.0 0.2 2.9e-05 24.1 0.0 3.6 3 0 0 3 3 3 2 Ankyrin repeat DUF294 PF03445.13 ETO30328.1 - 2.4e-07 30.6 0.0 5e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 Putative nucleotidyltransferase DUF294 Ank_5 PF13857.6 ETO30328.1 - 1e-06 28.9 0.2 1.5e-05 25.2 0.1 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO30328.1 - 7.5e-05 23.0 0.1 0.0021 18.4 0.0 2.7 2 0 0 2 2 2 1 Ankyrin repeat WD40 PF00400.32 ETO30329.1 - 5.2e-63 207.5 18.5 1.3e-08 35.3 0.2 7.6 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30329.1 - 7.1e-22 77.5 4.7 0.0004 20.6 0.0 8.0 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30329.1 - 1.2e-15 57.3 0.6 0.25 10.3 0.0 8.2 2 1 6 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO30329.1 - 1.6e-05 23.8 10.9 0.1 11.2 0.2 5.6 3 1 4 7 7 7 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO30329.1 - 4.5e-05 23.3 5.2 3.3 7.8 0.0 6.1 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO30329.1 - 0.00015 20.5 0.1 0.032 12.8 0.0 2.6 2 1 0 2 2 2 2 Cytochrome D1 heme domain Kelch_5 PF13854.6 ETO30329.1 - 0.0088 16.0 2.8 2 8.5 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO30329.1 - 0.016 15.5 5.4 0.91 9.9 0.5 5.0 5 0 0 5 5 5 0 Kelch motif Nbas_N PF15492.6 ETO30329.1 - 0.036 13.4 0.7 12 5.2 0.0 3.8 2 1 3 5 5 5 0 Neuroblastoma-amplified sequence, N terminal Kelch_4 PF13418.6 ETO30329.1 - 0.042 13.9 0.0 0.21 11.6 0.0 2.3 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO30329.1 - 0.062 12.9 0.2 0.42 10.2 0.1 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO30329.1 - 0.092 12.8 1.5 8.4 6.5 0.1 3.9 4 0 0 4 4 4 0 Kelch motif Proteasome_A_N PF10584.9 ETO30329.1 - 0.19 11.4 4.5 39 4.1 0.0 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO30330.1 - 1.4e-64 212.4 16.3 2.5e-09 37.6 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30330.1 - 1.5e-18 66.9 2.6 0.00096 19.4 0.0 6.3 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30330.1 - 1.8e-12 46.9 4.7 0.11 11.5 0.0 6.3 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO30330.1 - 3.6e-11 42.9 2.4 0.005 16.2 0.0 3.5 3 1 1 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO30330.1 - 1.7e-06 27.0 5.9 0.15 10.6 0.0 5.8 1 1 4 7 7 7 2 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO30330.1 - 4.2e-05 23.6 0.7 2.7 8.2 0.1 4.7 3 2 1 5 5 5 1 Strictosidine synthase Nbas_N PF15492.6 ETO30330.1 - 0.00025 20.5 1.4 2.6 7.3 0.0 3.9 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO30330.1 - 0.0003 19.4 1.0 0.42 9.1 0.0 3.4 1 1 2 4 4 4 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO30330.1 - 0.017 15.1 0.0 17 5.6 0.0 3.5 4 0 0 4 4 4 0 PQQ enzyme repeat SBD PF17882.1 ETO30330.1 - 0.025 14.4 0.4 4.7 7.1 0.1 3.3 1 1 2 3 3 3 0 OAA-family lectin sugar binding domain ROS_MUCR PF05443.11 ETO30330.1 - 0.032 14.3 0.3 3 7.9 0.1 3.4 2 1 2 4 4 4 0 ROS/MUCR transcriptional regulator protein PLD_C PF12357.8 ETO30330.1 - 0.042 13.8 0.7 23 5.0 0.0 4.2 5 0 0 5 5 5 0 Phospholipase D C terminal Nucleoporin_N PF08801.11 ETO30330.1 - 0.049 12.4 8.1 0.15 10.8 0.1 3.2 1 1 1 3 3 3 0 Nup133 N terminal like PD40 PF07676.12 ETO30330.1 - 0.82 9.7 6.6 7.9 6.6 0.0 4.4 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Trypan_PARP PF05887.11 ETO30333.1 - 0.0082 16.1 24.6 0.0082 16.1 24.6 3.2 3 1 1 4 4 4 1 Procyclic acidic repetitive protein (PARP) SID-1_RNA_chan PF13965.6 ETO30334.1 - 0.15 10.4 3.3 0.16 10.4 3.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 UQ_con PF00179.26 ETO30335.1 - 1.3e-16 60.5 0.7 2.2e-16 59.7 0.7 1.4 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme CBF PF03914.17 ETO30336.1 - 1.4e-18 67.5 0.2 5.2e-18 65.7 0.1 2.0 2 0 0 2 2 2 1 CBF/Mak21 family NOC3p PF07540.11 ETO30336.1 - 3.1e-10 40.4 0.3 1.5e-09 38.2 0.3 2.3 1 0 0 1 1 1 1 Nucleolar complex-associated protein HEAT PF02985.22 ETO30336.1 - 0.046 14.0 0.1 9 6.9 0.0 2.7 2 0 0 2 2 2 0 HEAT repeat TLD PF07534.16 ETO30338.1 - 3.8e-13 49.9 0.4 7.5e-13 48.9 0.4 1.5 1 0 0 1 1 1 1 TLD DUF2214 PF09980.9 ETO30338.1 - 0.39 10.5 1.3 2.6 7.8 0.1 2.2 1 1 1 2 2 2 0 Predicted membrane protein (DUF2214) CLP1_P PF16575.5 ETO30340.1 - 1.4e-36 126.0 0.4 9.2e-36 123.4 0.4 2.2 1 1 0 1 1 1 1 mRNA cleavage and polyadenylation factor CLP1 P-loop CLP1_N PF16573.5 ETO30340.1 - 2.5e-19 69.3 5.5 2.5e-11 43.6 0.4 2.7 3 0 0 3 3 3 2 N-terminal beta-sandwich domain of polyadenylation factor Clp1 PF06807.14 ETO30340.1 - 1.7e-12 47.8 0.1 4.3e-12 46.5 0.1 1.8 1 1 0 1 1 1 1 Pre-mRNA cleavage complex II protein Clp1 BUD22 PF09073.10 ETO30340.1 - 0.0041 16.5 0.8 0.0068 15.8 0.8 1.2 1 0 0 1 1 1 1 BUD22 DUF3439 PF11921.8 ETO30340.1 - 0.28 11.1 6.7 0.7 9.9 6.7 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) ELMO_CED12 PF04727.13 ETO30341.1 - 3.2e-11 43.6 1.5 8.8e-11 42.2 1.5 1.7 1 0 0 1 1 1 1 ELMO/CED-12 family EF-hand_7 PF13499.6 ETO30342.1 - 2.1e-22 79.4 2.4 6.8e-13 48.9 0.5 2.4 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO30342.1 - 2.4e-21 73.6 5.4 2e-06 26.9 0.2 3.6 3 0 0 3 3 3 3 EF hand EF-hand_6 PF13405.6 ETO30342.1 - 7.5e-18 62.9 4.2 5e-06 26.0 0.0 4.1 3 1 1 4 4 4 3 EF-hand domain EF-hand_5 PF13202.6 ETO30342.1 - 9.1e-18 62.9 8.4 6.1e-06 25.5 0.2 4.1 4 0 0 4 4 4 3 EF hand EF-hand_8 PF13833.6 ETO30342.1 - 8.1e-16 57.6 6.2 2.8e-07 30.3 1.4 3.5 2 1 1 3 3 3 3 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO30342.1 - 1.5e-06 28.5 0.1 0.00035 20.9 0.0 2.3 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO30342.1 - 1.6e-06 28.0 0.4 0.01 15.8 0.1 2.2 2 0 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand DUF3349 PF11829.8 ETO30342.1 - 0.02 15.7 0.7 0.77 10.6 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3349) EF-hand_10 PF14788.6 ETO30342.1 - 0.037 13.9 0.7 1.1 9.1 0.0 2.9 3 0 0 3 3 3 0 EF hand Excalibur PF05901.11 ETO30342.1 - 0.084 13.5 0.1 5.5 7.7 0.1 2.6 2 0 0 2 2 2 0 Excalibur calcium-binding domain Syd PF07348.12 ETO30342.1 - 0.13 11.9 0.0 0.21 11.3 0.0 1.3 1 0 0 1 1 1 0 Syd protein (SUKH-2) Leucyl-specific PF14795.6 ETO30342.1 - 0.13 12.3 0.4 6.3 6.9 0.0 2.7 2 1 0 2 2 2 0 Leucine-tRNA synthetase-specific domain Presenilin PF01080.17 ETO30343.1 - 0.019 13.7 0.3 0.026 13.3 0.3 1.2 1 0 0 1 1 1 0 Presenilin DUF262 PF03235.14 ETO30343.1 - 0.021 15.0 0.7 0.021 15.0 0.7 2.1 1 1 1 2 2 2 0 Protein of unknown function DUF262 Salp15 PF12115.8 ETO30343.1 - 0.097 13.1 7.0 0.036 14.5 2.9 2.4 2 2 0 2 2 2 0 Salivary protein of 15kDa inhibits CD4+ T cell activation Peptidase_S9 PF00326.21 ETO30344.1 - 2.3e-25 89.3 0.0 2.7e-25 89.1 0.0 1.1 1 0 0 1 1 1 1 Prolyl oligopeptidase family Abhydrolase_1 PF00561.20 ETO30344.1 - 1.6e-06 28.0 0.0 0.012 15.2 0.0 2.1 1 1 1 2 2 2 2 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO30344.1 - 6.5e-06 25.6 0.0 0.0052 16.1 0.0 2.1 2 0 0 2 2 2 2 Serine aminopeptidase, S33 DLH PF01738.18 ETO30344.1 - 0.00012 21.8 0.0 0.00017 21.3 0.0 1.2 1 0 0 1 1 1 1 Dienelactone hydrolase family Abhydrolase_3 PF07859.13 ETO30344.1 - 0.00066 19.6 0.0 0.0012 18.7 0.0 1.4 1 1 0 1 1 1 1 alpha/beta hydrolase fold PhoPQ_related PF10142.9 ETO30344.1 - 0.02 13.5 0.0 0.026 13.2 0.0 1.1 1 0 0 1 1 1 0 PhoPQ-activated pathogenicity-related protein Abhydrolase_2 PF02230.16 ETO30344.1 - 0.03 14.1 0.0 1.2 8.9 0.0 2.1 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase Tannase PF07519.11 ETO30344.1 - 0.13 11.1 0.0 1.1 8.1 0.0 1.9 2 0 0 2 2 2 0 Tannase and feruloyl esterase Tubulin_C PF03953.17 ETO30345.1 - 6.2e-28 97.5 0.0 8.6e-28 97.0 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain GWT1 PF06423.12 ETO30346.1 - 0.028 14.6 0.2 0.075 13.2 0.2 1.7 1 0 0 1 1 1 0 GWT1 RsgA_GTPase PF03193.16 ETO30347.1 - 9.8e-05 22.3 0.2 0.0015 18.5 0.2 3.2 1 1 0 1 1 1 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO30347.1 - 0.00016 21.7 1.5 0.0018 18.3 0.1 3.8 2 0 0 2 2 2 1 50S ribosome-binding GTPase P-mevalo_kinase PF04275.14 ETO30347.1 - 0.0011 18.9 0.9 0.0011 18.9 0.9 3.8 5 0 0 5 5 3 1 Phosphomevalonate kinase ABC_tran PF00005.27 ETO30347.1 - 0.0041 17.7 0.0 0.0041 17.7 0.0 5.8 6 1 0 6 6 6 1 ABC transporter AAA PF00004.29 ETO30347.1 - 0.021 15.2 1.7 6 7.3 0.0 4.1 3 0 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) PB1 PF00564.24 ETO30347.1 - 0.031 14.2 0.3 0.15 12.0 0.3 2.3 1 0 0 1 1 1 0 PB1 domain T2SSE PF00437.20 ETO30347.1 - 0.034 13.2 0.0 0.088 11.9 0.0 1.7 1 0 0 1 1 1 0 Type II/IV secretion system protein TetR PF13972.6 ETO30347.1 - 0.058 13.1 0.9 0.39 10.4 0.1 3.0 2 0 0 2 2 2 0 Bacterial transcriptional repressor AAA_19 PF13245.6 ETO30347.1 - 0.095 13.0 3.3 0.089 13.1 0.3 2.8 3 1 0 3 3 2 0 AAA domain Bestrophin PF01062.21 ETO30347.1 - 0.11 11.9 0.5 0.46 9.8 0.5 2.2 1 0 0 1 1 1 0 Bestrophin, RFP-TM, chloride channel AAA_29 PF13555.6 ETO30347.1 - 0.15 11.8 0.1 0.36 10.6 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain HetR_C PF18460.1 ETO30347.1 - 0.25 11.3 2.0 3.5 7.6 0.2 3.4 2 0 0 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain Usp PF00582.26 ETO30347.1 - 0.36 11.3 2.2 0.5 10.9 0.3 2.3 2 0 0 2 2 1 0 Universal stress protein family FtsK_SpoIIIE PF01580.18 ETO30347.1 - 4.1 6.7 7.0 1.4 8.3 0.0 3.4 4 0 0 4 4 4 0 FtsK/SpoIIIE family SecA_DEAD PF07517.14 ETO30348.1 - 9.4e-11 41.5 0.7 1.3e-09 37.8 0.0 2.8 3 0 0 3 3 3 1 SecA DEAD-like domain Helicase_C PF00271.31 ETO30348.1 - 0.00011 22.6 0.1 0.00088 19.6 0.0 2.6 2 0 0 2 2 2 1 Helicase conserved C-terminal domain YqgF PF14639.6 ETO30348.1 - 0.06 13.1 1.8 1.7 8.4 0.1 2.8 2 0 0 2 2 2 0 Holliday-junction resolvase-like of SPT6 zf-4CXXC_R1 PF10497.9 ETO30348.1 - 0.084 13.1 2.1 0.23 11.7 2.1 1.7 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 Presenilin PF01080.17 ETO30349.1 - 0.0058 15.4 5.0 0.0054 15.6 5.0 1.1 1 0 0 1 1 1 1 Presenilin Trypan_PARP PF05887.11 ETO30349.1 - 0.64 10.0 9.1 1.1 9.2 9.1 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) WD40_alt PF14077.6 ETO30350.1 - 0.0038 17.1 8.0 0.044 13.7 0.3 4.9 4 1 1 5 5 5 1 Alternative WD40 repeat motif Cep57_CLD_2 PF14197.6 ETO30350.1 - 0.0046 17.0 31.2 0.53 10.4 2.3 4.5 4 0 0 4 4 4 3 Centrosome localisation domain of PPC89 TMF_TATA_bd PF12325.8 ETO30350.1 - 0.019 15.2 13.2 0.019 15.2 13.2 4.5 3 2 1 4 4 4 0 TATA element modulatory factor 1 TATA binding GRIM-19 PF06212.12 ETO30350.1 - 0.02 14.8 1.5 0.051 13.5 1.5 1.6 1 0 0 1 1 1 0 GRIM-19 protein Peptidase_C39_2 PF13529.6 ETO30350.1 - 0.53 10.8 4.3 4.2 7.9 0.2 3.1 3 0 0 3 3 3 0 Peptidase_C39 like family Shugoshin_N PF07558.11 ETO30350.1 - 1.4 8.8 17.3 0.17 11.8 0.9 4.7 5 0 0 5 5 5 0 Shugoshin N-terminal coiled-coil region AAA_13 PF13166.6 ETO30350.1 - 2.6 6.6 40.2 0.037 12.7 28.5 2.2 1 1 1 2 2 2 0 AAA domain ATG16 PF08614.11 ETO30350.1 - 4.4 7.5 39.6 0.5 10.6 14.2 3.1 1 1 2 3 3 3 0 Autophagy protein 16 (ATG16) DASH_Spc19 PF08287.11 ETO30350.1 - 6.4 6.7 36.5 0.11 12.3 9.5 3.7 1 1 3 4 4 4 0 Spc19 BclA_C PF18573.1 ETO30351.1 - 0.0011 18.9 0.0 0.0017 18.3 0.0 1.3 1 0 0 1 1 1 1 BclA C-terminal domain Laminin_G_3 PF13385.6 ETO30351.1 - 0.011 15.9 0.4 1.5 9.0 0.1 2.4 2 1 1 3 3 3 0 Concanavalin A-like lectin/glucanases superfamily WD40 PF00400.32 ETO30353.1 - 4.9e-16 58.8 9.7 0.00017 22.3 0.1 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30353.1 - 7.9e-05 22.9 0.4 4.3 7.7 0.1 3.3 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO30353.1 - 0.0033 16.2 1.8 1.5 7.4 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Trypan_PARP PF05887.11 ETO30354.1 - 1.3 9.0 23.6 0.14 12.1 4.1 3.2 2 1 1 3 3 3 0 Procyclic acidic repetitive protein (PARP) Clathrin PF00637.20 ETO30355.1 - 2.3e-83 277.2 16.3 6.7e-29 100.6 2.7 3.1 3 0 0 3 3 3 3 Region in Clathrin and VPS TPR_14 PF13428.6 ETO30355.1 - 0.00052 20.6 1.8 3.1 8.9 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat Vps8 PF12816.7 ETO30355.1 - 0.021 14.3 2.0 3.3 7.1 0.1 3.0 3 0 0 3 3 3 0 Golgi CORVET complex core vacuolar protein 8 RLAN PF14401.6 ETO30355.1 - 0.075 12.7 1.6 12 5.6 0.0 3.2 4 0 0 4 4 4 0 RimK-like ATPgrasp N-terminal domain TSC22 PF01166.18 ETO30357.1 - 0.00016 21.9 22.9 0.026 14.9 0.2 5.0 4 1 1 5 5 5 2 TSC-22/dip/bun family Asp4 PF16996.5 ETO30357.1 - 0.039 13.7 1.1 7 6.5 0.0 2.8 2 0 0 2 2 2 0 Accessory secretory protein Sec Asp4 RNA_polI_A14 PF08203.11 ETO30357.1 - 0.79 10.5 5.1 0.63 10.8 2.0 2.4 2 0 0 2 2 2 0 Yeast RNA polymerase I subunit RPA14 ZapB PF06005.12 ETO30357.1 - 6.9 7.2 39.9 1 9.9 1.6 5.0 3 1 0 3 3 3 0 Cell division protein ZapB PRKG1_interact PF15898.5 ETO30358.1 - 0.0097 16.8 50.7 0.014 16.2 14.0 3.5 2 2 1 3 3 3 2 cGMP-dependent protein kinase interacting domain Pox_A_type_inc PF04508.12 ETO30358.1 - 0.088 12.7 16.5 4.4 7.3 0.4 5.4 4 1 1 5 5 5 0 Viral A-type inclusion protein repeat BST2 PF16716.5 ETO30358.1 - 0.81 10.3 49.9 0.62 10.7 5.3 5.3 3 2 1 5 5 5 0 Bone marrow stromal antigen 2 Golgin_A5 PF09787.9 ETO30358.1 - 0.83 9.1 56.6 0.26 10.7 20.7 3.0 1 1 1 3 3 3 0 Golgin subfamily A member 5 gpW PF02831.15 ETO30358.1 - 0.97 9.4 3.1 3.3 7.7 0.1 3.3 3 0 0 3 3 3 0 gpW HPPK PF01288.20 ETO30358.1 - 1.3 9.6 7.5 0.2 12.2 1.3 2.5 2 1 0 2 2 2 0 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK) DUF3584 PF12128.8 ETO30358.1 - 3.8 4.9 50.6 0.25 8.8 27.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) NAF PF03822.14 ETO30359.1 - 0.049 13.8 0.0 0.12 12.6 0.0 1.7 1 0 0 1 1 1 0 NAF domain ORC_WH_C PF18137.1 ETO30359.1 - 4.6 7.3 18.6 3.8 7.6 4.4 3.5 3 0 0 3 3 3 0 Origin recognition complex winged helix C-terminal Pkinase PF00069.25 ETO30360.1 - 9.1e-15 54.7 3.8 1e-14 54.6 3.8 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30360.1 - 3.8e-10 39.5 2.4 4.4e-10 39.3 2.4 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase DDE_Tnp_1_3 PF13612.6 ETO30360.1 - 0.023 14.7 1.9 0.033 14.2 1.9 1.2 1 0 0 1 1 1 0 Transposase DDE domain Pyr_redox_2 PF07992.14 ETO30361.1 - 3.4e-42 144.7 0.2 4.3e-42 144.3 0.2 1.1 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETO30361.1 - 5.4e-27 94.2 0.0 2.5e-26 92.1 0.0 2.0 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ETO30361.1 - 1e-15 58.1 0.2 2.4e-15 56.9 0.2 1.7 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 3HCDH_N PF02737.18 ETO30361.1 - 2.3e-05 24.4 0.2 4.4e-05 23.4 0.2 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain Pyr_redox_3 PF13738.6 ETO30361.1 - 0.00012 21.5 0.1 0.00017 21.0 0.1 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase 2-Hacid_dh_C PF02826.19 ETO30361.1 - 0.00092 18.6 0.0 0.0019 17.6 0.0 1.5 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain K_oxygenase PF13434.6 ETO30361.1 - 0.008 15.3 0.0 0.62 9.1 0.0 2.1 1 1 0 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) ThiF PF00899.21 ETO30361.1 - 0.0088 15.4 0.0 0.024 14.0 0.0 1.6 2 0 0 2 2 2 1 ThiF family 7tm_2 PF00002.24 ETO30361.1 - 0.015 14.5 0.0 0.022 14.0 0.0 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (Secretin family) DEP PF00610.21 ETO30362.1 - 9.1e-11 41.7 0.1 1.7e-10 40.8 0.1 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) DUF4404 PF14357.6 ETO30363.1 - 0.59 10.8 4.4 12 6.6 0.8 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) MMR1 PF08505.10 ETO30364.1 - 0.037 14.3 8.5 0.049 13.9 8.5 1.1 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein Dynamin_M PF01031.20 ETO30365.1 - 1.1e-90 303.7 0.9 1.1e-90 303.7 0.9 1.9 2 0 0 2 2 2 1 Dynamin central region Dynamin_N PF00350.23 ETO30365.1 - 1.7e-29 103.0 0.4 3.1e-28 98.9 0.0 2.7 2 0 0 2 2 2 1 Dynamin family GED PF02212.18 ETO30365.1 - 9.6e-26 89.8 2.5 9.6e-26 89.8 2.5 2.0 2 0 0 2 2 2 1 Dynamin GTPase effector domain DUF2972 PF11186.8 ETO30365.1 - 0.039 13.9 0.2 0.039 13.9 0.2 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2972) TFIIA PF03153.13 ETO30365.1 - 0.061 13.3 27.3 0.13 12.3 27.3 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Macoilin PF09726.9 ETO30365.1 - 2.4 6.6 32.0 0.59 8.6 24.6 2.2 2 0 0 2 2 2 0 Macoilin family Ndc1_Nup PF09531.10 ETO30365.1 - 3.9 6.0 18.2 7.2 5.2 16.9 1.9 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup Ecl1 PF12855.7 ETO30366.1 - 0.02 16.1 1.6 0.024 15.8 1.6 1.1 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins XPG_I PF00867.18 ETO30367.1 - 5.1e-20 71.6 0.0 5.1e-20 71.6 0.0 2.9 3 1 0 3 3 3 1 XPG I-region XPG_I_2 PF12813.7 ETO30367.1 - 1.3e-05 24.9 0.0 2.7e-05 23.8 0.0 1.6 1 0 0 1 1 1 1 XPG domain containing 5_3_exonuc PF01367.20 ETO30367.1 - 0.00023 21.7 0.0 0.00069 20.2 0.0 1.8 1 0 0 1 1 1 1 5'-3' exonuclease, C-terminal SAM fold Ntox1 PF15500.6 ETO30367.1 - 0.03 14.7 0.2 0.1 12.9 0.2 2.0 1 0 0 1 1 1 0 Putative RNase-like toxin, toxin_1 HHH_5 PF14520.6 ETO30367.1 - 0.12 13.0 0.0 0.46 11.1 0.0 2.0 2 0 0 2 2 2 0 Helix-hairpin-helix domain HHH PF00633.23 ETO30367.1 - 0.15 12.0 0.0 0.44 10.5 0.0 1.9 1 0 0 1 1 1 0 Helix-hairpin-helix motif Ndr PF03096.14 ETO30368.1 - 6.3e-35 120.2 0.0 7.9e-35 119.9 0.0 1.1 1 0 0 1 1 1 1 Ndr family Abhydrolase_1 PF00561.20 ETO30368.1 - 0.00042 20.0 0.0 0.00066 19.4 0.0 1.3 1 0 0 1 1 1 1 alpha/beta hydrolase fold Ndc1_Nup PF09531.10 ETO30369.1 - 0.56 8.8 16.7 0.77 8.4 16.7 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup KASH_CCD PF14662.6 ETO30370.1 - 3.9e-05 23.6 41.8 0.0011 18.8 24.5 2.7 1 1 1 2 2 2 1 Coiled-coil region of CCDC155 or KASH DUF1664 PF07889.12 ETO30370.1 - 0.0036 17.3 25.6 0.0055 16.7 5.4 4.2 2 1 2 4 4 4 2 Protein of unknown function (DUF1664) PSII_Pbs27 PF13326.6 ETO30370.1 - 0.0044 17.3 2.5 0.34 11.2 0.1 2.5 1 1 0 2 2 2 1 Photosystem II Pbs27 DUF4686 PF15742.5 ETO30370.1 - 0.0059 15.8 38.7 0.081 12.0 12.5 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF4686) BLOC1_2 PF10046.9 ETO30370.1 - 0.0075 16.5 2.5 0.0075 16.5 2.5 4.7 2 2 2 4 4 4 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF4472 PF14739.6 ETO30370.1 - 0.009 16.7 5.2 0.009 16.7 5.2 3.9 3 1 1 4 4 4 1 Domain of unknown function (DUF4472) DUF2353 PF09789.9 ETO30370.1 - 0.014 14.7 31.7 0.18 11.1 16.7 2.4 1 1 1 2 2 2 0 Uncharacterized coiled-coil protein (DUF2353) TSC22 PF01166.18 ETO30370.1 - 0.018 15.3 23.8 0.076 13.3 0.4 5.7 4 2 1 5 5 5 0 TSC-22/dip/bun family CENP-F_leu_zip PF10473.9 ETO30370.1 - 0.038 14.0 33.2 0.56 10.2 6.0 3.4 1 1 2 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 ETO30370.1 - 0.097 12.0 35.3 0.029 13.7 14.0 3.0 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding APG6_N PF17675.1 ETO30370.1 - 0.1 13.1 28.2 0.3 11.6 7.5 3.4 1 1 1 2 2 2 0 Apg6 coiled-coil region SpoOE-like PF09388.10 ETO30370.1 - 0.11 12.4 8.5 2.2 8.2 0.1 4.2 4 1 0 4 4 3 0 Spo0E like sporulation regulatory protein HALZ PF02183.18 ETO30370.1 - 0.13 12.5 28.6 0.34 11.2 0.2 5.9 4 2 2 6 6 5 0 Homeobox associated leucine zipper YabA PF06156.13 ETO30370.1 - 0.13 12.9 32.8 0.55 10.9 6.0 4.6 1 1 3 4 4 4 0 Initiation control protein YabA Filament PF00038.21 ETO30370.1 - 0.16 11.5 29.7 4 6.9 0.7 3.3 2 2 1 3 3 3 0 Intermediate filament protein DUF3450 PF11932.8 ETO30370.1 - 0.16 11.2 28.3 0.087 12.1 7.4 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) Cortex-I_coil PF09304.10 ETO30370.1 - 0.21 11.8 25.1 2.4 8.4 8.9 3.1 2 1 0 2 2 2 0 Cortexillin I, coiled coil Spc7 PF08317.11 ETO30370.1 - 0.34 9.8 34.9 0.089 11.7 13.1 2.6 1 1 1 2 2 2 0 Spc7 kinetochore protein CALCOCO1 PF07888.11 ETO30370.1 - 0.36 9.7 26.5 0.03 13.2 19.7 2.0 1 1 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like UPF0242 PF06785.11 ETO30370.1 - 0.36 10.9 35.0 0.058 13.5 13.9 2.7 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus HJURP_C PF12347.8 ETO30370.1 - 0.38 10.8 3.1 0.29 11.2 0.2 2.3 2 0 0 2 2 1 0 Holliday junction regulator protein family C-terminal repeat PRKG1_interact PF15898.5 ETO30370.1 - 0.7 10.8 36.6 1.1 10.2 9.7 4.2 2 1 2 4 4 3 0 cGMP-dependent protein kinase interacting domain Nucleoporin_FG2 PF15967.5 ETO30370.1 - 1.6 7.2 8.3 6.4 5.2 0.1 2.4 2 1 0 2 2 2 0 Nucleoporin FG repeated region DUF948 PF06103.11 ETO30370.1 - 1.8 8.9 15.7 30 5.0 5.3 4.6 3 2 1 4 4 4 0 Bacterial protein of unknown function (DUF948) ABC_tran_CTD PF16326.5 ETO30370.1 - 2.1 8.7 0.0 2.1 8.7 0.0 4.1 2 2 2 4 4 4 0 ABC transporter C-terminal domain FlgN PF05130.12 ETO30370.1 - 2.2 8.8 24.4 0.4 11.2 8.7 3.3 2 2 1 3 3 3 0 FlgN protein CHASE3 PF05227.13 ETO30370.1 - 2.2 8.2 7.4 0.45 10.4 2.6 2.3 2 2 0 2 2 2 0 CHASE3 domain Fzo_mitofusin PF04799.13 ETO30370.1 - 2.3 7.8 25.9 0.075 12.6 5.9 3.1 1 1 1 2 2 2 0 fzo-like conserved region Jnk-SapK_ap_N PF09744.9 ETO30370.1 - 3 8.1 32.4 2.1 8.6 8.5 3.9 1 1 3 4 4 4 0 JNK_SAPK-associated protein-1 bZIP_1 PF00170.21 ETO30370.1 - 3.1 8.0 33.4 0.096 12.8 3.2 5.6 2 2 2 5 5 5 0 bZIP transcription factor DUF4140 PF13600.6 ETO30370.1 - 3.6 8.1 11.4 3.7 8.1 0.5 3.8 2 2 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) Med10 PF09748.9 ETO30370.1 - 7.7 6.5 18.1 24 4.9 6.4 3.8 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex AKNA PF12443.8 ETO30370.1 - 8 7.2 18.4 0.5 11.1 8.5 3.5 2 2 1 3 3 3 0 AT-hook-containing transcription factor BAF1_ABF1 PF04684.13 ETO30372.1 - 0.00065 18.9 16.2 0.00065 18.9 16.2 2.3 2 0 0 2 2 2 1 BAF1 / ABF1 chromatin reorganising factor Utp14 PF04615.13 ETO30372.1 - 0.17 10.4 14.5 0.25 9.9 14.5 1.3 1 0 0 1 1 1 0 Utp14 protein Plant_all_beta PF10532.9 ETO30373.1 - 0.092 13.0 4.4 1.9 8.8 1.6 2.1 2 0 0 2 2 2 0 Plant specific N-all beta domain NUDIX PF00293.28 ETO30374.1 - 2.1e-12 47.2 0.0 3.1e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 NUDIX domain Orn_Arg_deC_N PF02784.16 ETO30375.1 - 1e-42 146.2 3.1 5.4e-41 140.6 1.5 2.8 2 1 0 2 2 2 2 Pyridoxal-dependent decarboxylase, pyridoxal binding domain Orn_DAP_Arg_deC PF00278.22 ETO30375.1 - 2.9e-10 40.2 0.0 3.5e-09 36.8 0.0 2.3 1 1 0 1 1 1 1 Pyridoxal-dependent decarboxylase, C-terminal sheet domain NVEALA PF14055.6 ETO30376.1 - 0.017 15.0 0.1 0.034 14.1 0.1 1.5 1 0 0 1 1 1 0 NVEALA protein Aldedh PF00171.22 ETO30377.1 - 4.3e-38 131.0 0.0 6.1e-38 130.5 0.0 1.1 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Kelch_6 PF13964.6 ETO30379.1 - 0.00013 22.1 0.4 0.0063 16.8 0.0 3.3 4 0 0 4 4 4 1 Kelch motif Sulfotransfer_4 PF17784.1 ETO30382.1 - 5.4e-10 39.5 1.3 1.3e-09 38.2 0.7 1.9 2 0 0 2 2 2 1 Sulfotransferase domain DUF772 PF05598.11 ETO30382.1 - 0.11 12.5 0.1 0.39 10.8 0.0 1.9 2 0 0 2 2 2 0 Transposase domain (DUF772) PGM_PMM_I PF02878.16 ETO30383.1 - 4.2e-07 29.8 0.0 7.7e-07 28.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I PGM_PMM_II PF02879.16 ETO30383.1 - 0.014 16.0 0.0 0.045 14.4 0.0 2.0 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II DUF3314 PF11771.8 ETO30383.1 - 0.035 14.2 0.1 0.15 12.2 0.0 2.1 3 0 0 3 3 3 0 Protein of unknown function (DUF3314) TMEM192 PF14802.6 ETO30384.1 - 0.0076 15.4 0.9 0.0076 15.4 0.9 1.8 1 1 1 2 2 2 1 TMEM192 family Guanylate_cyc PF00211.20 ETO30385.1 - 6.1e-25 87.9 0.0 7.9e-25 87.5 0.0 1.1 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain TMEM65 PF10507.9 ETO30385.1 - 0.12 12.3 0.0 0.31 11.0 0.0 1.7 2 0 0 2 2 2 0 Transmembrane protein 65 eIF2A PF08662.11 ETO30386.1 - 9.2e-08 32.2 0.1 0.00038 20.4 0.0 2.8 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ETO30386.1 - 2.3e-07 31.4 20.0 0.0011 19.7 0.3 6.4 5 1 0 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30386.1 - 2.2e-06 27.9 1.3 0.05 13.9 0.1 4.8 2 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain TB2_DP1_HVA22 PF03134.19 ETO30386.1 - 0.11 12.4 0.2 0.11 12.4 0.2 2.3 2 0 0 2 2 2 0 TB2/DP1, HVA22 family NAT PF04768.13 ETO30387.1 - 0.046 13.4 0.1 0.071 12.8 0.1 1.3 1 0 0 1 1 1 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase Sec66 PF09802.9 ETO30388.1 - 9.9e-09 35.0 0.7 9.9e-09 35.0 0.7 1.8 2 0 0 2 2 2 1 Preprotein translocase subunit Sec66 DUF3619 PF12279.8 ETO30388.1 - 0.069 13.5 0.0 0.14 12.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3619) SUIM_assoc PF16619.5 ETO30388.1 - 0.5 10.5 2.4 5.8 7.0 0.0 2.5 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TPR_12 PF13424.6 ETO30389.1 - 0.17 12.2 3.7 4.2 7.7 0.0 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO30389.1 - 0.42 10.9 12.1 7.2 7.0 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30389.1 - 0.96 9.4 12.1 9.1 6.3 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat Clr5 PF14420.6 ETO30390.1 - 0.088 13.1 0.1 0.15 12.3 0.1 1.4 1 0 0 1 1 1 0 Clr5 domain FtsK_gamma PF09397.10 ETO30390.1 - 0.11 12.3 0.0 0.26 11.1 0.0 1.6 2 0 0 2 2 2 0 Ftsk gamma domain Apis_Csd PF11671.8 ETO30390.1 - 0.35 10.9 5.0 0.51 10.3 5.0 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein Ribosomal_L20 PF00453.18 ETO30391.1 - 0.041 14.0 0.1 0.097 12.8 0.1 1.6 1 0 0 1 1 1 0 Ribosomal protein L20 Fungal_lectin_2 PF18647.1 ETO30391.1 - 0.79 10.2 3.6 6 7.4 0.0 3.1 2 1 1 3 3 3 0 Alpha-galactosyl-binding fungal lectin Lebercilin PF15619.6 ETO30392.1 - 0.0039 16.9 4.3 0.0039 16.9 4.3 1.9 1 1 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease DegS PF05384.11 ETO30392.1 - 0.01 15.3 7.9 0.05 13.1 0.1 2.2 1 1 1 2 2 2 0 Sensor protein DegS LPP PF04728.13 ETO30392.1 - 0.017 15.5 1.0 0.19 12.1 0.1 2.3 2 0 0 2 2 2 0 Lipoprotein leucine-zipper DHR10 PF18595.1 ETO30392.1 - 0.048 13.7 8.2 1.8 8.7 0.1 2.6 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain BRE1 PF08647.11 ETO30392.1 - 0.052 13.6 0.4 0.052 13.6 0.4 2.6 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF4094 PF13334.6 ETO30392.1 - 0.069 13.6 10.1 0.14 12.6 2.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) OEP PF02321.18 ETO30392.1 - 0.069 12.9 9.0 0.027 14.3 4.2 1.9 1 1 1 2 2 2 0 Outer membrane efflux protein Wtap PF17098.5 ETO30392.1 - 0.07 13.1 7.6 0.21 11.5 7.1 1.9 1 1 1 2 2 2 0 WTAP/Mum2p family TolA_bind_tri PF16331.5 ETO30392.1 - 0.071 13.2 2.3 0.093 12.8 0.6 2.2 1 1 0 1 1 1 0 TolA binding protein trimerisation Fzo_mitofusin PF04799.13 ETO30392.1 - 0.075 12.6 9.4 0.46 10.0 5.7 2.1 2 0 0 2 2 2 0 fzo-like conserved region Baculo_PEP_C PF04513.12 ETO30392.1 - 0.11 12.5 1.2 0.15 12.1 1.2 1.3 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus DUF724 PF05266.14 ETO30392.1 - 0.11 12.3 12.8 0.03 14.2 8.5 2.1 1 1 2 3 3 3 0 Protein of unknown function (DUF724) Exonuc_VII_L PF02601.15 ETO30392.1 - 0.13 11.9 7.9 0.15 11.6 7.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Phage_GP20 PF06810.11 ETO30392.1 - 0.16 11.8 11.1 2.8 7.7 0.2 2.1 1 1 0 2 2 2 0 Phage minor structural protein GP20 Tup_N PF08581.10 ETO30392.1 - 0.32 11.3 5.0 0.73 10.2 0.3 2.5 1 1 1 2 2 2 0 Tup N-terminal V-SNARE PF05008.15 ETO30392.1 - 0.49 10.8 7.1 2.1 8.8 5.0 2.8 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus DUF2203 PF09969.9 ETO30392.1 - 0.57 10.9 4.0 7.4 7.3 0.1 2.3 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) OmpH PF03938.14 ETO30392.1 - 1.3 9.3 9.5 4.6 7.6 0.4 2.2 1 1 1 2 2 2 0 Outer membrane protein (OmpH-like) DUF4407 PF14362.6 ETO30392.1 - 3.5 6.9 10.0 12 5.2 10.0 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Glycohydro_20b2 PF14845.6 ETO30392.1 - 4.1 8.1 9.7 18 6.0 9.7 1.9 1 1 0 1 1 1 0 beta-acetyl hexosaminidase like Lectin_N PF03954.14 ETO30392.1 - 5.7 6.7 10.1 3.1 7.5 4.4 2.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain Jnk-SapK_ap_N PF09744.9 ETO30392.1 - 6.3 7.0 14.9 0.37 11.0 0.6 2.1 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 TPR_MLP1_2 PF07926.12 ETO30392.1 - 6.6 6.8 15.9 1.4 9.0 0.9 2.3 1 1 0 2 2 2 0 TPR/MLP1/MLP2-like protein YlqD PF11068.8 ETO30392.1 - 7.2 7.0 10.2 34 4.8 0.2 2.2 1 1 1 2 2 2 0 YlqD protein HAD PF12710.7 ETO30393.1 - 0.24 11.8 0.5 2.2 8.6 0.5 2.1 1 1 0 1 1 1 0 haloacid dehalogenase-like hydrolase DHC_N2 PF08393.13 ETO30394.1 - 4.6e-83 279.6 7.3 5.2e-83 279.4 7.3 1.0 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 2 AMH_N PF04709.12 ETO30394.1 - 0.025 13.5 0.1 0.042 12.8 0.1 1.3 1 0 0 1 1 1 0 Anti-Mullerian hormone, N terminal region DUF3730 PF12530.8 ETO30395.1 - 0.28 10.7 1.0 0.38 10.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3730) FliD_N PF02465.18 ETO30395.1 - 1.4 9.6 5.4 2.7 8.7 5.4 1.6 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus PAS_10 PF13596.6 ETO30396.1 - 0.031 14.9 0.0 0.09 13.4 0.0 1.8 1 1 1 2 2 2 0 PAS domain TTD PF12148.8 ETO30396.1 - 0.049 13.5 0.7 0.076 12.9 0.7 1.3 1 0 0 1 1 1 0 Tandem tudor domain within UHRF1 DZR PF12773.7 ETO30396.1 - 0.36 10.9 7.9 0.13 12.3 3.6 2.2 2 0 0 2 2 2 0 Double zinc ribbon Podoplanin PF05808.11 ETO30396.1 - 0.37 10.9 1.6 0.63 10.1 0.1 1.9 1 1 0 2 2 2 0 Podoplanin TFIIA PF03153.13 ETO30397.1 - 1.3e-05 25.4 28.6 1.3e-05 25.4 28.6 2.1 2 0 0 2 2 2 1 Transcription factor IIA, alpha/beta subunit GREB1 PF15782.5 ETO30397.1 - 0.028 11.6 18.7 0.037 11.2 18.7 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer DUF966 PF06136.13 ETO30397.1 - 0.038 13.7 17.6 0.061 13.0 17.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF966) PARM PF17061.5 ETO30397.1 - 0.33 11.0 20.5 0.6 10.2 20.5 1.4 1 0 0 1 1 1 0 PARM Mucin PF01456.17 ETO30397.1 - 0.57 10.2 18.1 1.1 9.2 18.1 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein PAT1 PF09770.9 ETO30397.1 - 5.6 5.1 34.3 10 4.2 34.3 1.4 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Ndc1_Nup PF09531.10 ETO30397.1 - 7.7 5.1 19.6 11 4.6 19.6 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Proteasome PF00227.26 ETO30398.1 - 1.5e-38 132.3 0.1 5.8e-21 74.9 0.0 3.1 3 0 0 3 3 3 3 Proteasome subunit Proteasome_A_N PF10584.9 ETO30398.1 - 2.5e-11 43.1 0.0 4.3e-11 42.3 0.0 1.4 1 0 0 1 1 1 1 Proteasome subunit A N-terminal signature Ion_trans PF00520.31 ETO30399.1 - 7.5e-15 54.8 22.1 1.3e-14 54.0 22.1 1.3 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO30399.1 - 0.19 10.4 12.9 0.16 10.6 3.7 2.4 2 0 0 2 2 2 0 Polycystin cation channel DEAD PF00270.29 ETO30400.1 - 1.4e-12 47.8 0.1 4.2e-12 46.2 0.1 1.8 1 0 0 1 1 1 1 DEAD/DEAH box helicase CDT1 PF08839.11 ETO30400.1 - 0.00017 21.9 8.1 0.00062 20.1 8.1 1.9 1 1 0 1 1 1 1 DNA replication factor CDT1 like DUF1840 PF08895.11 ETO30400.1 - 0.017 15.4 1.0 0.017 15.4 1.0 2.7 2 1 2 4 4 4 0 Domain of unknown function (DUF1840) CDC45 PF02724.14 ETO30400.1 - 0.13 10.5 9.9 0.32 9.2 9.0 1.8 2 0 0 2 2 2 0 CDC45-like protein DUF1998 PF09369.10 ETO30401.1 - 1.9e-23 83.0 0.1 5.7e-23 81.5 0.1 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF1998) Helicase_C PF00271.31 ETO30401.1 - 1.9e-10 41.1 0.0 5e-10 39.7 0.0 1.8 1 1 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO30401.1 - 3.1e-05 23.8 0.6 0.00013 21.8 0.0 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase Sad1_UNC PF07738.13 ETO30402.1 - 0.00019 21.5 0.0 0.00028 20.9 0.0 1.2 1 0 0 1 1 1 1 Sad1 / UNC-like C-terminal Sulfotransfer_2 PF03567.14 ETO30402.1 - 0.003 17.5 0.1 0.12 12.3 0.0 2.1 2 0 0 2 2 2 2 Sulfotransferase family ubiquitin PF00240.23 ETO30402.1 - 0.11 12.2 0.0 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 Ubiquitin family SR-25 PF10500.9 ETO30403.1 - 0.0012 18.5 13.8 0.0014 18.3 13.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein SRC-1 PF08832.10 ETO30403.1 - 0.055 14.5 4.6 0.1 13.7 4.6 1.5 1 0 0 1 1 1 0 Steroid receptor coactivator AF-4 PF05110.13 ETO30403.1 - 1.1 7.2 11.6 1 7.3 11.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PUB PF09409.10 ETO30404.1 - 6.7e-10 38.8 0.1 5.3e-09 35.9 0.1 2.5 2 0 0 2 2 2 1 PUB domain Methyltransf_25 PF13649.6 ETO30404.1 - 1.5e-08 35.2 0.0 3.1e-08 34.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO30404.1 - 5.9e-07 30.1 0.0 1.3e-06 28.9 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO30404.1 - 1.8e-05 25.4 0.3 5e-05 24.0 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain MTS PF05175.14 ETO30404.1 - 2.2e-05 24.0 0.0 4.8e-05 23.0 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_31 PF13847.6 ETO30404.1 - 2.4e-05 24.2 0.0 5.4e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO30404.1 - 6.7e-05 22.9 1.3 0.0002 21.4 0.0 2.1 1 1 1 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO30404.1 - 0.0003 20.6 0.0 0.00054 19.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 ETO30404.1 - 0.0053 16.3 0.0 0.018 14.5 0.0 1.8 2 0 0 2 2 2 1 CheR methyltransferase, SAM binding domain EIIBC-GUT_N PF03612.14 ETO30404.1 - 0.0088 15.8 0.3 0.017 14.8 0.3 1.5 1 0 0 1 1 1 1 Sorbitol phosphotransferase enzyme II N-terminus CMAS PF02353.20 ETO30404.1 - 0.027 13.8 0.0 0.047 13.0 0.0 1.5 1 0 0 1 1 1 0 Mycolic acid cyclopropane synthetase Ubie_methyltran PF01209.18 ETO30404.1 - 0.065 12.6 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family FAM176 PF14851.6 ETO30404.1 - 0.065 12.9 1.7 0.12 12.0 1.7 1.4 1 0 0 1 1 1 0 FAM176 family Phage_Gp23 PF10669.9 ETO30404.1 - 0.098 13.0 4.2 0.27 11.6 4.2 1.7 1 0 0 1 1 1 0 Protein gp23 (Bacteriophage A118) Pep1_7 PF17232.2 ETO30404.1 - 6.7 7.2 10.4 0.6 10.6 5.4 1.8 2 0 0 2 2 1 0 Elicitor peptide 1-7 Glycos_transf_4 PF00953.21 ETO30405.1 - 2.1e-37 128.6 10.6 2.1e-37 128.6 10.6 2.5 3 0 0 3 3 3 1 Glycosyl transferase family 4 DUF2013 PF09431.10 ETO30406.1 - 2.3e-05 24.6 0.4 4.7e-05 23.6 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF2013) Mito_carr PF00153.27 ETO30407.1 - 1.1e-29 102.2 0.1 1.2e-20 73.2 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein MaoC_dehydratas PF01575.19 ETO30407.1 - 0.073 12.6 0.1 0.13 11.9 0.1 1.3 1 0 0 1 1 1 0 MaoC like domain Metallophos PF00149.28 ETO30408.1 - 0.0013 19.3 0.0 0.0024 18.4 0.0 1.4 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos PF00149.28 ETO30409.1 - 1.1e-20 75.0 0.0 2.7e-19 70.5 0.0 2.6 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Kelch_4 PF13418.6 ETO30409.1 - 8e-14 51.4 0.3 0.0043 17.0 0.0 5.0 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO30409.1 - 8.5e-11 41.9 0.0 1e-07 32.1 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO30409.1 - 3.4e-09 36.5 0.0 0.26 11.3 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO30409.1 - 7.5e-07 29.2 0.0 0.43 10.9 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO30409.1 - 1.8e-05 24.2 0.0 0.033 13.8 0.0 3.8 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO30409.1 - 0.022 14.7 6.5 1.8 8.7 0.1 4.8 5 0 0 5 5 5 0 Kelch motif Rep_fac-A_3 PF08661.11 ETO30409.1 - 0.47 10.8 3.4 14 6.1 0.0 3.2 3 0 0 3 3 3 0 Replication factor A protein 3 Syntaxin_2 PF14523.6 ETO30410.1 - 9 6.7 10.7 1.3e+03 -0.2 10.7 2.5 1 1 0 1 1 1 0 Syntaxin-like protein Menin PF05053.13 ETO30411.1 - 1.6 7.0 5.9 1.4 7.2 5.9 1.0 1 0 0 1 1 1 0 Menin RRS1 PF04939.12 ETO30412.1 - 0.0087 15.9 1.2 0.012 15.5 0.1 1.7 2 0 0 2 2 2 1 Ribosome biogenesis regulatory protein (RRS1) WBP-1 PF11669.8 ETO30412.1 - 1.4 9.5 7.5 9.7 6.9 1.1 3.1 2 2 1 3 3 3 0 WW domain-binding protein 1 DUF4517 PF15006.6 ETO30413.1 - 4.7e-10 39.8 0.9 1.4e-09 38.3 0.9 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF4517) CDV3 PF15359.6 ETO30413.1 - 0.012 16.1 14.3 0.51 10.8 7.2 2.6 2 0 0 2 2 2 0 Carnitine deficiency-associated protein 3 DUF2052 PF09747.9 ETO30413.1 - 0.018 15.2 8.5 0.72 10.0 4.1 2.7 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) DUF2556 PF10831.8 ETO30413.1 - 0.14 12.2 0.3 1.4 8.9 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2556) Ribosomal_60s PF00428.19 ETO30413.1 - 0.44 11.2 6.7 1.3 9.7 6.7 1.7 1 0 0 1 1 1 0 60s Acidic ribosomal protein Spt5_N PF11942.8 ETO30413.1 - 2.6 9.1 18.6 0.075 14.0 8.0 2.6 2 0 0 2 2 2 0 Spt5 transcription elongation factor, acidic N-terminal PI3K_1B_p101 PF10486.9 ETO30413.1 - 5.8 4.6 13.2 6.3 4.4 6.1 2.1 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PBP1_TM PF14812.6 ETO30413.1 - 6.8 7.1 7.4 13 6.2 0.3 2.7 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CoA_transf_3 PF02515.17 ETO30414.1 - 5.4e-107 358.1 0.0 4.8e-74 249.7 0.0 2.1 2 0 0 2 2 2 2 CoA-transferase family III RhoGAP PF00620.27 ETO30416.1 - 5.5e-05 23.0 0.2 0.00023 21.0 0.2 2.0 1 1 0 1 1 1 1 RhoGAP domain Ammonium_transp PF00909.21 ETO30417.1 - 6.8e-18 64.5 1.1 7.7e-18 64.4 1.1 1.0 1 0 0 1 1 1 1 Ammonium Transporter Family Na_Pi_cotrans PF02690.15 ETO30417.1 - 0.059 13.5 1.5 0.095 12.8 1.5 1.3 1 0 0 1 1 1 0 Na+/Pi-cotransporter Ammonium_transp PF00909.21 ETO30418.1 - 1.9e-24 86.1 9.0 9.5e-24 83.8 9.0 1.8 1 1 0 1 1 1 1 Ammonium Transporter Family DUF5316 PF17247.2 ETO30418.1 - 2.6 8.1 7.3 2.2 8.3 0.1 3.3 2 1 1 3 3 3 0 Family of unknown function (DUF5316) Peptidase_C36 PF05415.11 ETO30419.1 - 0.024 14.9 0.0 0.038 14.2 0.0 1.3 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase Pkinase PF00069.25 ETO30420.1 - 0.0082 15.5 0.0 0.012 15.0 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain EI24 PF07264.11 ETO30420.1 - 0.035 14.3 1.6 0.05 13.8 1.7 1.3 1 1 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) DUF3464 PF11947.8 ETO30420.1 - 1.6 8.5 4.1 24 4.6 0.0 2.6 3 0 0 3 3 3 0 Photosynthesis affected mutant 68 PBP1_TM PF14812.6 ETO30420.1 - 3.2 8.2 11.0 5.9 7.3 11.0 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PP2C PF00481.21 ETO30421.1 - 1.5e-46 159.1 0.0 2.9e-42 145.1 0.0 2.1 1 1 0 2 2 2 2 Protein phosphatase 2C DUF2489 PF10675.9 ETO30422.1 - 0.025 14.5 7.2 0.033 14.1 7.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) ALMT PF11744.8 ETO30422.1 - 1.8 7.3 11.5 1.9 7.2 11.5 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter ORC3_N PF07034.11 ETO30422.1 - 2 7.4 8.2 2.2 7.3 8.2 1.0 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 3 N-terminus Vfa1 PF08432.10 ETO30422.1 - 4.5 7.6 22.3 4.8 7.5 22.3 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PTPlike_phytase PF14566.6 ETO30423.1 - 7.2e-19 68.4 0.4 7.9e-18 65.1 0.4 2.7 1 1 0 1 1 1 1 Inositol hexakisphosphate HTH_39 PF14090.6 ETO30423.1 - 0.051 13.3 0.0 0.14 11.9 0.0 1.7 1 0 0 1 1 1 0 Helix-turn-helix domain Pox_Ag35 PF03286.14 ETO30424.1 - 0.09 12.6 10.7 0.24 11.2 9.3 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein ALMT PF11744.8 ETO30424.1 - 0.87 8.4 9.6 1.1 8.0 9.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Zip PF02535.22 ETO30424.1 - 2.2 7.4 8.4 3 7.0 8.4 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Macoilin PF09726.9 ETO30424.1 - 2.7 6.4 14.7 3.1 6.3 14.7 1.1 1 0 0 1 1 1 0 Macoilin family RP-C_C PF11800.8 ETO30424.1 - 3.5 7.7 6.1 9.2 6.3 5.6 1.9 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF2076 PF09849.9 ETO30424.1 - 4.8 7.1 18.3 7.2 6.6 18.3 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Menin PF05053.13 ETO30424.1 - 4.9 5.4 15.6 6.8 4.9 15.6 1.2 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO30424.1 - 6.2 5.5 15.4 9.9 4.8 15.4 1.2 1 0 0 1 1 1 0 Presenilin Glyco_transf_92 PF01697.27 ETO30426.1 - 7e-10 39.0 10.8 4.7e-09 36.3 10.8 2.0 1 1 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO30426.1 - 7.1e-06 26.4 4.5 7.7e-06 26.3 2.3 2.2 1 1 1 2 2 2 1 Glycosyl transferase family 2 AP_endonuc_2 PF01261.24 ETO30427.1 - 0.0071 15.8 0.0 0.0082 15.6 0.0 1.2 1 0 0 1 1 1 1 Xylose isomerase-like TIM barrel RRM_1 PF00076.22 ETO30428.1 - 4.7e-12 45.6 1.3 4.4e-06 26.4 0.0 3.9 4 0 0 4 4 4 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DASH_Spc19 PF08287.11 ETO30428.1 - 0.042 13.7 0.0 0.07 13.0 0.0 1.3 1 0 0 1 1 1 0 Spc19 Limkain-b1 PF11608.8 ETO30428.1 - 0.097 12.8 1.9 2.3 8.4 0.1 2.9 3 1 0 3 3 3 0 Limkain b1 DUF4283 PF14111.6 ETO30428.1 - 0.12 11.9 0.0 0.42 10.1 0.0 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4283) Guanylate_cyc PF00211.20 ETO30429.1 - 8.3e-22 77.7 0.0 1.5e-21 76.9 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Bin3 PF06859.12 ETO30429.1 - 2.5 8.8 10.1 5.5 7.7 0.0 3.9 4 0 0 4 4 4 0 Bicoid-interacting protein 3 (Bin3) DUF2031 PF09592.10 ETO30430.1 - 0.00013 21.6 7.6 0.00018 21.1 7.6 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2031) Ly49 PF08391.10 ETO30430.1 - 0.0043 17.4 1.9 0.0043 17.4 1.9 2.7 2 1 0 2 2 2 1 Ly49-like protein, N-terminal region Takusan PF04822.13 ETO30430.1 - 0.015 15.2 4.1 0.015 15.2 4.1 2.8 1 1 1 2 2 2 0 Takusan Phasin PF05597.11 ETO30430.1 - 0.031 14.3 8.1 0.044 13.8 8.1 1.2 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) HSBP1 PF06825.12 ETO30430.1 - 0.04 13.8 3.0 0.089 12.7 3.0 1.6 1 0 0 1 1 1 0 Heat shock factor binding protein 1 Exonuc_VII_L PF02601.15 ETO30430.1 - 0.062 12.9 4.8 0.065 12.8 4.8 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit MIS13 PF08202.11 ETO30430.1 - 0.078 12.3 10.3 0.098 11.9 10.3 1.1 1 0 0 1 1 1 0 Mis12-Mtw1 protein family AAA_11 PF13086.6 ETO30430.1 - 0.1 12.4 6.8 0.14 11.9 6.8 1.1 1 0 0 1 1 1 0 AAA domain T4SS PF07996.11 ETO30430.1 - 0.13 12.7 7.5 0.19 12.1 7.5 1.2 1 0 0 1 1 1 0 Type IV secretion system proteins FapA PF03961.13 ETO30430.1 - 0.21 10.1 12.1 0.27 9.8 12.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DUF4407 PF14362.6 ETO30430.1 - 0.36 10.1 5.3 0.54 9.6 5.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) PP2C_C PF07830.13 ETO30430.1 - 0.51 10.8 5.1 0.59 10.6 4.0 1.8 1 1 0 1 1 1 0 Protein serine/threonine phosphatase 2C, C-terminal domain Cep57_MT_bd PF06657.13 ETO30430.1 - 0.81 10.2 14.5 0.3 11.6 1.3 2.3 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 PIN_8 PF18476.1 ETO30430.1 - 1.1 9.0 9.3 1.4 8.7 9.3 1.1 1 0 0 1 1 1 0 PIN like domain DUF5401 PF17380.2 ETO30430.1 - 1.2 7.2 9.9 1.5 6.8 9.9 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) ABC_tran_CTD PF16326.5 ETO30430.1 - 1.8 8.9 18.2 3.9 7.8 7.8 2.2 1 1 1 2 2 2 0 ABC transporter C-terminal domain Spc7 PF08317.11 ETO30430.1 - 2.6 6.9 15.9 3.6 6.4 15.9 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein DUF1461 PF07314.11 ETO30430.1 - 4 7.3 13.6 10 6.0 13.6 1.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1461) HU-CCDC81_euk_1 PF14908.6 ETO30431.1 - 0.022 14.9 0.1 0.052 13.7 0.1 1.6 1 0 0 1 1 1 0 CCDC81 eukaryotic HU domain 1 TraX PF05857.11 ETO30431.1 - 0.056 13.5 0.1 0.077 13.0 0.1 1.2 1 0 0 1 1 1 0 TraX protein 7TMR-DISM_7TM PF07695.11 ETO30432.1 - 0.0071 16.3 8.9 0.016 15.1 8.9 1.5 1 1 0 1 1 1 1 7TM diverse intracellular signalling OPT PF03169.15 ETO30432.1 - 0.062 11.9 6.6 0.081 11.5 6.6 1.1 1 0 0 1 1 1 0 OPT oligopeptide transporter protein Ni_hydr_CYTB PF01292.20 ETO30432.1 - 0.14 11.7 5.4 0.42 10.2 2.6 2.0 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 DUF2207 PF09972.9 ETO30432.1 - 3.3 6.4 4.4 4.4 6.0 3.9 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) TNFR_16_TM PF18422.1 ETO30432.1 - 8 6.5 7.4 3.2 7.8 0.1 3.2 3 0 0 3 3 3 0 Tumor necrosis factor receptor member 16 trans-membrane domain ADH_zinc_N PF00107.26 ETO30433.1 - 2.2e-21 76.2 0.0 3.4e-21 75.6 0.0 1.3 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO30433.1 - 6.8e-18 66.0 0.0 1.5e-17 64.9 0.0 1.6 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N PF08240.12 ETO30433.1 - 8.3e-07 28.9 0.0 1.6e-06 28.0 0.0 1.5 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_N_2 PF16884.5 ETO30433.1 - 0.0076 16.1 0.0 0.015 15.1 0.0 1.6 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase Ferritin_2 PF13668.6 ETO30433.1 - 0.1 12.8 0.0 0.18 12.0 0.0 1.4 1 0 0 1 1 1 0 Ferritin-like domain TrkA_N PF02254.18 ETO30433.1 - 0.11 12.8 0.1 0.2 11.9 0.1 1.4 1 0 0 1 1 1 0 TrkA-N domain 2-Hacid_dh_C PF02826.19 ETO30433.1 - 0.12 11.7 0.1 0.86 8.9 0.0 2.1 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain WD40 PF00400.32 ETO30434.1 - 4.5e-53 176.0 16.9 5.4e-12 46.0 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30434.1 - 1.9e-24 85.7 0.7 9e-06 25.9 0.0 5.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PQQ_2 PF13360.6 ETO30434.1 - 5.6e-11 42.5 6.2 6.5e-06 25.9 0.3 2.3 1 1 2 3 3 3 3 PQQ-like domain WD40_like PF17005.5 ETO30434.1 - 9.6e-11 41.5 0.1 0.0058 16.0 0.0 3.2 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO30434.1 - 1.5e-08 34.0 0.1 0.82 8.6 0.0 4.2 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO30434.1 - 1.2e-05 25.2 4.0 9.3 6.3 0.0 4.7 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO30434.1 - 0.00012 20.7 2.2 0.13 10.8 0.1 3.1 1 1 2 3 3 3 3 Cytochrome D1 heme domain Gmad1 PF10647.9 ETO30434.1 - 0.00014 21.7 0.2 0.01 15.6 0.2 2.7 1 1 0 1 1 1 1 Lipoprotein LpqB beta-propeller domain DUF5570 PF17731.1 ETO30434.1 - 0.0012 19.0 8.1 1.2 9.2 0.1 4.2 1 1 3 4 4 4 1 Family of unknown function (DUF5570) DUF4265 PF14085.6 ETO30434.1 - 0.0014 18.6 0.2 6.9 6.7 0.0 3.6 1 1 3 4 4 4 2 Domain of unknown function (DUF4265) Me-amine-dh_H PF06433.11 ETO30434.1 - 0.0084 15.0 0.0 0.66 8.8 0.0 2.4 1 1 3 4 4 4 2 Methylamine dehydrogenase heavy chain (MADH) AcetylCoA_hyd_C PF13336.6 ETO30434.1 - 0.0097 15.8 3.1 8.9 6.2 0.1 4.1 4 1 1 5 5 5 1 Acetyl-CoA hydrolase/transferase C-terminal domain Frtz PF11768.8 ETO30434.1 - 0.025 12.9 0.0 1.7 6.9 0.0 3.0 1 1 3 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz Spc29 PF17082.5 ETO30434.1 - 0.1 12.4 0.8 0.96 9.2 0.4 2.6 1 1 1 2 2 2 0 Spindle Pole Component 29 Proteasome_A_N PF10584.9 ETO30434.1 - 0.24 11.1 10.4 43 3.9 0.1 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature CSN4_RPN5_eIF3a PF18420.1 ETO30434.1 - 1.8 8.8 13.2 76 3.6 0.1 5.1 5 0 0 5 5 5 0 CSN4/RPN5/eIF3a helix turn helix domain Phage_TAC_3 PF06896.11 ETO30435.1 - 0.16 12.6 2.2 0.28 11.8 0.3 2.1 2 1 0 2 2 2 0 Phage tail assembly chaperone proteins, TAC SAM_KSR1 PF13543.6 ETO30436.1 - 0.011 15.9 0.2 0.018 15.2 0.2 1.4 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 SKG6 PF08693.10 ETO30436.1 - 0.5 9.8 2.2 0.85 9.1 2.2 1.3 1 0 0 1 1 1 0 Transmembrane alpha-helix domain SAM_1 PF00536.30 ETO30437.1 - 1.4e-08 35.0 0.0 2.6e-08 34.2 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO30437.1 - 0.0069 16.5 0.0 0.012 15.7 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO30437.1 - 0.075 13.3 0.1 0.23 11.7 0.0 1.9 2 0 0 2 2 2 0 Ste50p, sterile alpha motif RRF PF01765.19 ETO30437.1 - 0.078 12.9 0.0 0.078 12.9 0.0 2.0 3 0 0 3 3 3 0 Ribosome recycling factor SH3_1 PF00018.28 ETO30437.1 - 0.17 11.5 2.0 5.3 6.7 0.0 2.5 1 1 1 2 2 2 0 SH3 domain FAM176 PF14851.6 ETO30438.1 - 0.041 13.6 1.0 0.06 13.0 1.0 1.2 1 0 0 1 1 1 0 FAM176 family Vpu PF00558.19 ETO30438.1 - 0.33 10.7 0.9 0.62 9.9 0.9 1.4 1 0 0 1 1 1 0 Vpu protein DSHCT PF08148.12 ETO30439.1 - 0.015 15.0 0.2 0.022 14.4 0.2 1.3 1 1 0 1 1 1 0 DSHCT (NUC185) domain Dna2 PF08696.11 ETO30439.1 - 0.018 14.8 2.1 0.026 14.3 2.1 1.3 1 0 0 1 1 1 0 DNA replication factor Dna2 DUF4347 PF14252.6 ETO30439.1 - 0.072 12.9 0.0 0.097 12.5 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4347) PIG-P PF08510.12 ETO30440.1 - 6.7e-05 22.8 0.3 0.13 12.2 0.0 3.5 3 0 0 3 3 3 2 PIG-P TRP PF06011.12 ETO30440.1 - 0.0011 17.8 16.2 0.026 13.3 8.5 3.2 3 0 0 3 3 3 2 Transient receptor potential (TRP) ion channel Zip PF02535.22 ETO30440.1 - 0.0011 18.2 7.2 0.05 12.8 1.0 3.1 3 0 0 3 3 3 2 ZIP Zinc transporter PI3K_1B_p101 PF10486.9 ETO30440.1 - 0.0038 15.1 6.6 0.0084 13.9 6.6 1.5 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit DUF4834 PF16118.5 ETO30440.1 - 0.0068 17.4 0.7 0.0068 17.4 0.7 5.4 6 0 0 6 6 5 1 Domain of unknown function (DUF4834) Ctr PF04145.15 ETO30440.1 - 0.0096 16.6 6.7 10 6.7 7.3 4.0 3 1 0 3 3 3 1 Ctr copper transporter family CoA_binding_3 PF13727.6 ETO30440.1 - 0.035 14.1 0.4 0.24 11.4 0.3 2.3 2 0 0 2 2 2 0 CoA-binding domain DUF4381 PF14316.6 ETO30440.1 - 0.052 13.8 0.0 0.052 13.8 0.0 3.4 4 0 0 4 4 4 0 Domain of unknown function (DUF4381) OATP PF03137.20 ETO30440.1 - 0.068 11.5 17.3 0.046 12.0 7.2 3.8 3 1 0 3 3 3 0 Organic Anion Transporter Polypeptide (OATP) family TMEMspv1-c74-12 PF11044.8 ETO30440.1 - 0.075 13.0 0.1 0.075 13.0 0.1 3.2 3 0 0 3 3 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Menin PF05053.13 ETO30440.1 - 0.09 11.1 14.6 0.0079 14.6 5.7 2.3 2 0 0 2 2 2 0 Menin LapA_dom PF06305.11 ETO30440.1 - 0.26 11.2 2.1 0.94 9.3 0.2 2.9 2 0 0 2 2 2 0 Lipopolysaccharide assembly protein A domain SpoIIIAH PF12685.7 ETO30440.1 - 0.52 10.1 22.4 0.026 14.4 9.8 3.1 3 0 0 3 3 3 0 SpoIIIAH-like protein Neur_chan_memb PF02932.16 ETO30440.1 - 1.4 8.9 11.9 0.037 14.1 2.8 2.8 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Folliculin PF11704.8 ETO30440.1 - 3.1 7.7 7.4 2.8 7.8 4.2 2.2 2 0 0 2 2 2 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF4446 PF14584.6 ETO30440.1 - 8.8 6.3 7.1 1.1 9.2 1.1 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) MAS20 PF02064.15 ETO30440.1 - 9.9 6.3 12.7 0.12 12.4 0.3 2.8 3 0 0 3 3 2 0 MAS20 protein import receptor SAM_1 PF00536.30 ETO30441.1 - 3.4e-07 30.6 0.0 7.5e-07 29.5 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO30441.1 - 3.7e-07 30.2 0.0 7.3e-07 29.2 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) bZIP_1 PF00170.21 ETO30441.1 - 2.3 8.4 16.7 0.81 9.8 10.9 2.9 2 0 0 2 2 2 0 bZIP transcription factor DUF2681 PF10883.8 ETO30441.1 - 2.7 8.5 8.6 4.5 7.7 6.1 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) HD PF01966.22 ETO30442.1 - 6.9e-07 29.5 0.9 1.3e-06 28.6 0.9 1.4 1 0 0 1 1 1 1 HD domain DUF1247 PF06851.11 ETO30442.1 - 0.0084 16.1 1.1 0.018 15.0 0.0 1.9 1 1 1 2 2 2 1 Protein of unknown function (DUF1247) DUF4473 PF14747.6 ETO30442.1 - 0.034 14.7 1.5 0.056 14.0 0.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4473) DUF2804 PF10974.8 ETO30444.1 - 0.1 12.1 1.7 0.11 12.0 1.7 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2804) UPF0515 PF15135.6 ETO30444.1 - 0.13 11.6 0.8 0.17 11.2 0.8 1.1 1 0 0 1 1 1 0 Uncharacterised protein UPF0515 Pkinase PF00069.25 ETO30445.1 - 3.9e-70 236.2 0.3 8.3e-54 182.7 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30445.1 - 6.2e-38 130.6 0.2 3.3e-30 105.2 0.1 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase POLO_box PF00659.18 ETO30445.1 - 1.6e-24 85.8 1.8 2.8e-14 53.0 0.1 2.7 2 0 0 2 2 2 2 POLO box duplicated region Kinase-like PF14531.6 ETO30445.1 - 1.2e-05 24.8 0.1 0.047 13.0 0.0 2.8 3 0 0 3 3 3 2 Kinase-like Haspin_kinase PF12330.8 ETO30445.1 - 4.7e-05 22.5 0.7 0.00025 20.1 0.7 2.2 1 1 0 1 1 1 1 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO30445.1 - 5.6e-05 22.1 0.0 0.00011 21.1 0.0 1.5 1 0 0 1 1 1 1 Fungal protein kinase APH PF01636.23 ETO30445.1 - 0.0041 17.1 0.3 0.028 14.3 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO30445.1 - 0.087 12.2 0.3 0.14 11.5 0.3 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family RRM_1 PF00076.22 ETO30447.1 - 1.1e-17 63.6 0.0 2.2e-17 62.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO30447.1 - 0.00013 21.6 0.1 0.00023 20.7 0.1 1.5 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) WWE PF02825.20 ETO30447.1 - 0.00016 22.2 0.0 0.00037 21.0 0.0 1.6 1 0 0 1 1 1 1 WWE domain RRM_occluded PF16842.5 ETO30447.1 - 0.00021 21.1 0.0 0.00057 19.7 0.0 1.7 1 0 0 1 1 1 1 Occluded RNA-recognition motif RRM_7 PF16367.5 ETO30447.1 - 0.026 14.6 0.0 0.5 10.5 0.0 2.4 1 1 0 2 2 2 0 RNA recognition motif SPOB_ab PF14682.6 ETO30447.1 - 0.048 13.7 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal RRM_8 PF11835.8 ETO30447.1 - 0.097 12.9 0.0 0.2 11.9 0.0 1.6 1 0 0 1 1 1 0 RRM-like domain TF_Zn_Ribbon PF08271.12 ETO30449.1 - 0.01 15.3 0.2 0.01 15.3 0.2 2.9 4 1 0 4 4 4 0 TFIIB zinc-binding zf-UBR PF02207.20 ETO30449.1 - 0.019 15.1 1.6 0.12 12.6 0.5 2.6 2 1 0 2 2 2 0 Putative zinc finger in N-recognin (UBR box) HypA PF01155.19 ETO30449.1 - 0.025 14.6 1.0 0.057 13.4 1.0 1.6 1 0 0 1 1 1 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Tnp_zf-ribbon_2 PF13842.6 ETO30449.1 - 0.27 12.1 4.9 1.3 9.9 0.2 2.7 2 0 0 2 2 2 0 DDE_Tnp_1-like zinc-ribbon DZR PF12773.7 ETO30449.1 - 0.38 10.8 6.5 0.52 10.4 2.1 2.7 3 0 0 3 3 3 0 Double zinc ribbon zinc_ribbon_2 PF13240.6 ETO30449.1 - 5.3 6.9 8.8 0.36 10.6 0.8 2.8 3 0 0 3 3 3 0 zinc-ribbon domain DUF4974 PF16344.5 ETO30450.1 - 0.12 12.4 0.1 0.32 11.0 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4974) Lipase_3 PF01764.25 ETO30451.1 - 0.1 12.5 0.0 0.22 11.4 0.0 1.6 1 1 0 1 1 1 0 Lipase (class 3) YbhQ PF11076.8 ETO30452.1 - 0.019 15.0 1.4 0.019 15.0 1.4 2.5 2 0 0 2 2 2 0 Putative inner membrane protein YbhQ Tim54 PF11711.8 ETO30454.1 - 0.0016 17.3 1.6 0.0016 17.3 1.6 3.7 3 1 0 3 3 3 1 Inner membrane protein import complex subunit Tim54 Ribosomal_60s PF00428.19 ETO30454.1 - 0.31 11.6 0.1 0.31 11.6 0.1 2.7 2 0 0 2 2 2 0 60s Acidic ribosomal protein SID-1_RNA_chan PF13965.6 ETO30454.1 - 0.37 9.1 8.5 3.4 6.0 5.3 2.4 2 0 0 2 2 2 0 dsRNA-gated channel SID-1 Calc_CGRP_IAPP PF00214.19 ETO30454.1 - 0.57 10.6 0.0 0.57 10.6 0.0 2.5 2 0 0 2 2 2 0 Calcitonin / CGRP / IAPP family Rot1 PF10681.9 ETO30454.1 - 3.8 7.0 6.1 3.5 7.1 0.1 3.3 3 1 0 3 3 3 0 Chaperone for protein-folding within the ER, fungal Mitofilin PF09731.9 ETO30454.1 - 6.2 5.5 32.4 1.1 8.1 17.3 2.1 2 0 0 2 2 2 0 Mitochondrial inner membrane protein Presenilin PF01080.17 ETO30454.1 - 7.8 5.2 34.7 1.1 8.0 1.4 3.2 3 0 0 3 3 3 0 Presenilin ASH PF15780.5 ETO30455.1 - 2.5e-09 37.2 5.0 0.81 9.9 0.0 6.0 6 1 0 6 6 6 5 Abnormal spindle-like microcephaly-assoc'd, ASPM-SPD-2-Hydin Motile_Sperm PF00635.26 ETO30455.1 - 4.4e-06 26.5 8.2 0.043 13.7 0.0 4.9 5 0 0 5 5 5 2 MSP (Major sperm protein) domain TMEM131_like PF12371.8 ETO30455.1 - 0.0074 16.5 4.3 12 6.2 0.1 5.1 5 0 0 5 5 5 2 Transmembrane protein 131-like Motile_Sperm PF00635.26 ETO30456.1 - 0.088 12.7 4.5 0.79 9.6 0.1 3.6 3 0 0 3 3 3 0 MSP (Major sperm protein) domain PapD-like PF14874.6 ETO30456.1 - 0.14 12.4 0.2 11 6.2 0.1 2.9 3 0 0 3 3 3 0 Flagellar-associated PapD-like DUF1129 PF06570.11 ETO30457.1 - 0.053 13.0 1.9 0.11 11.9 1.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1129) Secretin_N_2 PF07655.13 ETO30459.1 - 0.012 16.2 3.4 0.021 15.4 3.4 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain LpqV PF17301.2 ETO30459.1 - 0.17 12.2 0.0 0.36 11.1 0.0 1.5 1 0 0 1 1 1 0 Putative lipoprotein LpqV SelP_N PF04592.14 ETO30459.1 - 0.2 11.1 1.3 0.51 9.7 0.0 2.2 3 0 0 3 3 3 0 Selenoprotein P, N terminal region PAE PF03283.13 ETO30460.1 - 3.6e-08 32.9 3.3 3.6e-08 32.9 3.3 1.5 1 1 0 1 1 1 1 Pectinacetylesterase TPR_12 PF13424.6 ETO30461.1 - 1.2e-35 121.6 10.8 7.6e-19 67.8 0.6 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30461.1 - 7.3e-20 69.9 12.7 2.6e-08 33.4 0.7 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30461.1 - 3.3e-17 61.8 0.5 2.2e-09 36.9 0.1 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO30461.1 - 3.8e-16 57.8 3.4 4.3e-06 26.4 0.1 4.6 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO30461.1 - 3.1e-15 55.0 10.2 2e-05 24.3 0.2 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30461.1 - 2e-11 43.1 13.1 3.6e-06 26.7 1.8 5.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO30461.1 - 7.3e-07 29.1 0.2 0.035 14.5 0.0 3.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO30461.1 - 2.3e-05 24.0 11.2 0.26 11.0 1.6 5.0 2 2 2 4 4 4 3 TPR repeat TPR_16 PF13432.6 ETO30461.1 - 0.00086 19.9 0.1 3.4 8.4 0.0 2.9 2 1 0 2 2 2 2 Tetratricopeptide repeat PPR PF01535.20 ETO30461.1 - 0.0074 16.5 0.9 0.12 12.6 0.0 3.3 3 0 0 3 3 2 1 PPR repeat DUF5113 PF17140.4 ETO30461.1 - 0.0085 15.9 1.3 5 6.9 0.0 2.8 3 0 0 3 3 3 2 Domain of unknown function (DUF5113) MIT PF04212.18 ETO30461.1 - 0.015 15.4 10.3 0.11 12.6 0.2 4.7 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO30461.1 - 0.022 15.4 1.8 0.63 10.8 0.1 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO30461.1 - 0.025 15.4 0.0 28 5.9 0.0 3.0 3 0 0 3 3 2 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO30461.1 - 0.053 13.5 0.1 0.26 11.2 0.1 2.2 1 1 0 1 1 1 0 Caspase domain TPR_3 PF07720.12 ETO30461.1 - 0.077 13.0 3.1 0.56 10.3 1.4 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO30461.1 - 0.23 11.7 1.8 1.5 9.1 0.4 2.7 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF4404 PF14357.6 ETO30461.1 - 1.1 9.9 0.0 1.1 9.9 0.0 2.5 3 0 0 3 3 2 0 Domain of unknown function (DUF4404) zf-C2H2 PF00096.26 ETO30463.1 - 4.1e-07 30.1 49.5 0.00086 19.6 1.1 7.3 7 0 0 7 7 7 4 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO30463.1 - 2e-05 24.8 32.8 0.12 12.8 3.3 6.6 6 0 0 6 6 6 3 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO30463.1 - 2.8e-05 24.6 54.9 0.0089 16.8 3.4 8.0 8 0 0 8 8 8 4 C2H2-type zinc finger zf-met PF12874.7 ETO30463.1 - 3.9e-05 23.9 24.1 0.0082 16.5 1.4 6.5 6 0 0 6 6 6 2 Zinc-finger of C2H2 type zf-C2H2_jaz PF12171.8 ETO30463.1 - 0.00028 21.1 26.2 0.26 11.6 2.7 6.5 6 0 0 6 6 6 2 Zinc-finger double-stranded RNA-binding zf-H2C2_5 PF13909.6 ETO30463.1 - 0.01 15.5 2.5 0.01 15.5 2.5 4.9 4 1 0 4 4 4 0 C2H2-type zinc-finger domain GAGA PF09237.11 ETO30463.1 - 0.079 12.8 7.8 0.39 10.5 0.1 3.0 3 0 0 3 3 3 0 GAGA factor DUF2841 PF11001.8 ETO30463.1 - 0.082 13.0 0.3 0.22 11.6 0.1 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2841) FOXP-CC PF16159.5 ETO30463.1 - 3 8.6 0.0 3 8.6 0.0 4.2 3 1 1 4 4 4 0 FOXP coiled-coil domain C2 PF00168.30 ETO30464.1 - 8.4e-14 51.7 0.0 6.5e-10 39.2 0.0 2.6 3 0 0 3 3 3 2 C2 domain CAS_C PF12026.8 ETO30465.1 - 4.2 7.4 7.6 0.63 10.1 2.9 1.8 2 0 0 2 2 2 0 Crk-Associated Substrate C-terminal domain MAT1 PF06391.13 ETO30466.1 - 1.1e-09 38.4 7.2 2.2e-09 37.5 7.2 1.4 1 0 0 1 1 1 1 CDK-activating kinase assembly factor MAT1 zf-C3HC4_5 PF17121.5 ETO30466.1 - 2.8e-05 23.9 8.2 0.00012 21.9 8.1 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Baculo_IE-1 PF05290.11 ETO30466.1 - 0.0022 17.9 4.4 0.0058 16.6 4.4 1.7 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) SPOR PF05036.13 ETO30466.1 - 0.069 13.5 0.1 4 7.9 0.0 2.4 1 1 1 2 2 2 0 Sporulation related domain DUF4446 PF14584.6 ETO30466.1 - 0.12 12.4 2.5 0.29 11.1 2.5 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) zf-C3HC4_3 PF13920.6 ETO30466.1 - 0.32 10.9 11.3 0.33 10.9 9.2 2.1 2 1 1 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO30466.1 - 1.1 9.7 9.9 2.5 8.5 9.9 1.7 1 0 0 1 1 1 0 Ring finger domain Rtt102p PF09510.10 ETO30466.1 - 2.3 8.4 7.5 0.97 9.6 3.2 2.2 1 1 1 2 2 2 0 Rtt102p-like transcription regulator protein Zn-ribbon_8 PF09723.10 ETO30466.1 - 5.5 7.2 7.3 0.61 10.2 0.2 2.8 2 1 0 2 2 2 0 Zinc ribbon domain CFAP91 PF14738.6 ETO30467.1 - 4.2e-16 59.4 14.8 4.2e-16 59.4 14.8 2.2 3 1 0 3 3 3 1 Cilia- and flagella-associated protein 91 SpoU_sub_bind PF08032.12 ETO30467.1 - 0.59 10.4 3.1 0.88 9.9 1.1 2.4 2 0 0 2 2 2 0 RNA 2'-O ribose methyltransferase substrate binding KMP11 PF03037.16 ETO30467.1 - 3.4 8.5 10.2 11 6.9 1.7 3.0 3 0 0 3 3 3 0 Kinetoplastid membrane protein 11 Asp PF00026.23 ETO30468.1 - 3.7e-37 128.4 1.8 5.2e-37 127.9 1.8 1.2 1 0 0 1 1 1 1 Eukaryotic aspartyl protease TAXi_N PF14543.6 ETO30468.1 - 9.5e-11 42.2 2.5 2e-10 41.2 2.5 1.6 1 0 0 1 1 1 1 Xylanase inhibitor N-terminal S_locus_glycop PF00954.20 ETO30468.1 - 0.29 11.7 5.4 0.74 10.4 5.4 1.7 1 1 0 1 1 1 0 S-locus glycoprotein domain zf-C2H2 PF00096.26 ETO30469.1 - 0.0034 17.8 0.1 0.0034 17.8 0.1 3.0 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO30469.1 - 0.47 11.0 5.8 0.29 11.6 1.4 2.6 2 0 0 2 2 2 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO30469.1 - 0.54 11.2 0.1 0.54 11.2 0.1 3.4 2 0 0 2 2 2 0 C2H2-type zinc finger zf-BED PF02892.15 ETO30469.1 - 1.3 9.1 6.0 4.8 7.3 0.3 2.6 1 1 1 2 2 2 0 BED zinc finger DUF2269 PF10027.9 ETO30470.1 - 0.019 15.0 0.9 0.031 14.4 0.9 1.3 1 0 0 1 1 1 0 Predicted integral membrane protein (DUF2269) NST1 PF13945.6 ETO30470.1 - 0.18 11.9 8.0 0.32 11.1 8.0 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF1387 PF07139.11 ETO30470.1 - 1.6 8.4 10.6 2 8.1 10.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Ist1 PF03398.14 ETO30471.1 - 0.00015 21.7 1.8 0.00022 21.2 1.3 1.6 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway Spem1 PF15670.5 ETO30471.1 - 0.13 11.8 4.2 0.48 10.0 0.7 2.1 2 0 0 2 2 2 0 Spermatid maturation protein 1 WD40 PF00400.32 ETO30474.1 - 1.3e-28 98.7 1.5 4e-10 40.1 0.2 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30474.1 - 8.3e-13 48.5 0.2 0.00027 21.2 0.0 3.0 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30474.1 - 1.3e-06 27.6 0.0 0.13 11.2 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO30474.1 - 0.00039 20.4 0.0 0.00086 19.2 0.0 1.5 1 1 0 1 1 1 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO30474.1 - 0.00045 20.1 0.1 3.6 7.6 0.0 3.3 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO30474.1 - 0.00056 18.7 0.1 1.4 7.5 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO30474.1 - 0.0018 17.6 0.0 0.003 16.9 0.0 1.4 1 1 0 1 1 1 1 WD40-like domain DUF5570 PF17731.1 ETO30474.1 - 0.0037 17.3 0.0 0.33 11.1 0.0 2.5 1 1 2 3 3 3 1 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO30474.1 - 0.015 14.4 0.1 0.019 14.1 0.1 1.1 1 0 0 1 1 1 0 Coatomer WD associated region PALB2_WD40 PF16756.5 ETO30474.1 - 0.031 13.2 0.4 0.35 9.7 0.1 2.2 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Proteasome_A_N PF10584.9 ETO30474.1 - 0.046 13.4 0.8 17 5.2 0.0 3.2 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO30476.1 - 3.5e-44 147.9 5.2 1.3e-09 38.4 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30476.1 - 4.6e-17 62.1 0.3 0.00027 21.2 0.0 4.9 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30476.1 - 1.1e-11 44.3 0.0 0.0025 16.8 0.0 4.7 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DUF5570 PF17731.1 ETO30476.1 - 6.5e-07 29.5 0.0 0.57 10.3 0.1 4.4 2 1 3 5 5 5 2 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO30476.1 - 1e-06 28.3 0.1 0.0039 16.6 0.0 2.5 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO30476.1 - 1.3e-06 28.1 0.4 3.5 7.7 0.1 4.8 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO30476.1 - 1.1e-05 24.2 0.2 0.0018 16.9 0.2 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO30476.1 - 6.6e-05 21.7 1.4 2.3 6.8 0.0 4.5 2 1 3 5 5 5 2 Nucleoporin Nup120/160 HARP PF07443.13 ETO30476.1 - 0.0005 19.6 0.0 0.73 9.5 0.0 3.2 4 0 0 4 4 4 2 HepA-related protein (HARP) Nbas_N PF15492.6 ETO30476.1 - 0.001 18.5 0.1 0.38 10.0 0.0 2.8 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO30476.1 - 0.0022 16.8 1.7 1.6 7.4 0.1 3.3 1 1 1 3 3 3 2 Nup133 N terminal like DUF1797 PF08796.10 ETO30476.1 - 0.0067 16.5 0.0 7.2 6.8 0.0 2.9 2 1 1 3 3 3 2 Protein of unknown function (DUF1797) Proteasome_A_N PF10584.9 ETO30476.1 - 0.43 10.3 4.7 7.2 6.4 0.0 3.9 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DIOX_N PF14226.6 ETO30477.1 - 7.7e-23 81.5 0.1 1.2e-22 80.9 0.1 1.3 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal 2OG-FeII_Oxy PF03171.20 ETO30477.1 - 7.1e-22 77.8 0.1 1.2e-21 77.0 0.1 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Ion_trans PF00520.31 ETO30479.1 - 3.8e-12 46.0 7.2 6.1e-12 45.3 7.2 1.3 1 0 0 1 1 1 1 Ion transport protein BTB PF00651.31 ETO30480.1 - 1.2e-18 67.3 2.1 9.2e-16 58.1 0.4 2.3 1 1 1 2 2 2 2 BTB/POZ domain phage_tail_N PF08400.10 ETO30480.1 - 0.097 12.7 0.0 0.15 12.1 0.0 1.3 1 0 0 1 1 1 0 Prophage tail fibre N-terminal Pox_Ag35 PF03286.14 ETO30481.1 - 0.02 14.7 12.0 0.026 14.3 12.0 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein AAR2 PF05282.11 ETO30481.1 - 0.021 14.2 3.5 0.025 14.0 3.5 1.1 1 0 0 1 1 1 0 AAR2 protein Corazonin PF17308.2 ETO30481.1 - 0.18 12.2 15.4 0.27 11.6 15.4 1.2 1 0 0 1 1 1 0 Pro-corazonin TCP PF03634.13 ETO30481.1 - 0.23 12.0 6.5 0.29 11.7 6.5 1.2 1 0 0 1 1 1 0 TCP family transcription factor Menin PF05053.13 ETO30481.1 - 0.34 9.2 6.3 0.39 9.0 6.3 1.2 1 0 0 1 1 1 0 Menin Zip PF02535.22 ETO30481.1 - 0.38 9.9 2.2 0.47 9.6 2.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter MRNIP PF15749.5 ETO30481.1 - 0.47 11.2 10.8 0.62 10.8 10.8 1.3 1 0 0 1 1 1 0 MRN-interacting protein GCD14 PF08704.10 ETO30481.1 - 0.81 9.3 2.9 1 9.0 2.9 1.3 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit Presenilin PF01080.17 ETO30481.1 - 1.7 7.3 6.0 2 7.1 6.0 1.1 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO30481.1 - 2.9 6.6 6.3 3.3 6.4 6.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF4834 PF16118.5 ETO30481.1 - 9.1 7.3 8.2 21 6.2 8.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) RCC1_2 PF13540.6 ETO30482.1 - 3.5e-09 36.2 4.0 2.6e-05 23.9 0.3 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO30482.1 - 0.083 13.5 1.3 0.49 11.1 0.0 2.9 3 1 0 3 3 3 0 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO30483.1 - 4e-12 45.6 7.3 9.1e-06 25.3 2.7 3.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO30483.1 - 1.5e-11 44.7 8.4 0.001 19.7 0.1 4.7 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat Hamartin PF04388.12 ETO30483.1 - 0.0048 15.6 2.3 0.0075 15.0 2.3 1.3 1 0 0 1 1 1 1 Hamartin protein Methyltransf_12 PF08242.12 ETO30483.1 - 0.015 16.0 0.4 0.036 14.8 0.4 1.8 1 0 0 1 1 1 0 Methyltransferase domain Menin PF05053.13 ETO30483.1 - 0.073 11.4 11.0 0.11 10.9 11.0 1.1 1 0 0 1 1 1 0 Menin Tim54 PF11711.8 ETO30483.1 - 1.8 7.3 8.8 3.1 6.5 8.8 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 RP-C_C PF11800.8 ETO30483.1 - 1.8 8.6 6.8 4 7.5 6.8 1.6 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF3450 PF11932.8 ETO30483.1 - 1.9 7.8 7.4 3.9 6.7 7.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) XRN_M PF17846.1 ETO30483.1 - 5.7 5.8 12.9 11 4.8 12.9 1.4 1 0 0 1 1 1 0 Xrn1 helical domain Presenilin PF01080.17 ETO30483.1 - 7.1 5.3 9.7 12 4.5 9.7 1.3 1 0 0 1 1 1 0 Presenilin MazG-like PF12643.7 ETO30484.1 - 5.6e-09 36.1 0.7 5.6e-09 36.1 0.7 2.1 2 0 0 2 2 2 1 MazG-like family SAM_1 PF00536.30 ETO30484.1 - 8.3e-09 35.8 0.3 1.9e-08 34.6 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) MazG PF03819.17 ETO30484.1 - 5.7e-07 29.6 0.1 1.3e-06 28.5 0.1 1.6 1 0 0 1 1 1 1 MazG nucleotide pyrophosphohydrolase domain SAM_2 PF07647.17 ETO30484.1 - 1.9e-05 24.7 0.2 5.5e-05 23.2 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO30484.1 - 0.038 14.2 0.6 0.083 13.1 0.0 1.8 2 0 0 2 2 2 0 Ste50p, sterile alpha motif DNA_pol_viral_C PF00336.18 ETO30484.1 - 0.13 11.6 1.8 6.7 6.0 0.6 2.1 2 0 0 2 2 2 0 DNA polymerase (viral) C-terminal domain Cytochrom_B_N_2 PF13631.6 ETO30485.1 - 0.1 12.6 0.2 0.15 12.1 0.2 1.2 1 0 0 1 1 1 0 Cytochrome b(N-terminal)/b6/petB SPC25 PF06703.11 ETO30485.1 - 0.16 11.8 6.4 17 5.2 6.4 2.3 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) GWT1 PF06423.12 ETO30485.1 - 0.22 11.6 1.2 0.31 11.2 1.2 1.3 1 0 0 1 1 1 0 GWT1 Ribosomal_L24e PF01246.20 ETO30486.1 - 1e-14 54.4 2.4 2.6e-14 53.2 2.4 1.7 1 0 0 1 1 1 1 Ribosomal protein L24e CAGE1 PF15066.6 ETO30487.1 - 0.0013 17.5 7.4 0.0017 17.1 7.4 1.1 1 0 0 1 1 1 1 Cancer-associated gene protein 1 family Biopterin_H PF00351.21 ETO30487.1 - 0.0096 15.0 0.5 0.012 14.7 0.5 1.2 1 0 0 1 1 1 1 Biopterin-dependent aromatic amino acid hydroxylase GAS PF13851.6 ETO30487.1 - 0.012 14.9 10.8 0.018 14.4 7.9 2.2 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Remorin_C PF03763.13 ETO30487.1 - 0.024 14.5 1.7 0.05 13.5 1.7 1.6 1 1 0 1 1 1 0 Remorin, C-terminal region CorA PF01544.18 ETO30487.1 - 0.03 13.6 3.2 0.11 11.8 3.4 1.7 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein Syntaxin-6_N PF09177.11 ETO30487.1 - 0.17 12.5 5.6 0.15 12.6 4.3 1.7 2 0 0 2 2 2 0 Syntaxin 6, N-terminal GvpL_GvpF PF06386.11 ETO30487.1 - 0.2 11.5 3.3 1.4 8.8 3.3 1.9 1 1 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF Phlebovirus_NSM PF07246.11 ETO30489.1 - 0.024 14.0 0.2 0.032 13.6 0.2 1.1 1 0 0 1 1 1 0 Phlebovirus nonstructural protein NS-M Lipase3_N PF03893.16 ETO30489.1 - 0.08 13.0 0.5 1.6 8.8 0.0 2.3 2 0 0 2 2 2 0 Lipase 3 N-terminal region cNMP_binding PF00027.29 ETO30490.1 - 7.9e-09 35.5 0.0 1.3e-08 34.8 0.0 1.3 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain Ion_trans PF00520.31 ETO30490.1 - 7.3e-05 22.1 1.1 0.00012 21.4 1.1 1.3 1 0 0 1 1 1 1 Ion transport protein Ion_trans_2 PF07885.16 ETO30490.1 - 0.45 10.5 6.8 0.061 13.3 2.5 1.7 2 0 0 2 2 2 0 Ion channel RSRP PF17069.5 ETO30491.1 - 0.054 13.1 13.2 0.1 12.2 13.2 1.4 1 0 0 1 1 1 0 Arginine/Serine-Rich protein 1 DUF4131 PF13567.6 ETO30492.1 - 0.0084 15.8 0.0 0.0092 15.6 0.0 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4131) PRCH PF03967.13 ETO30492.1 - 0.0088 16.3 0.0 0.013 15.8 0.0 1.3 1 0 0 1 1 1 1 Photosynthetic reaction centre, H-chain N-terminal region O-antigen_lig PF13425.6 ETO30492.1 - 0.11 11.2 6.1 0.14 10.9 6.1 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CRA PF06589.11 ETO30492.1 - 0.21 11.7 11.7 0.051 13.7 8.4 1.7 1 1 1 2 2 2 0 Circumsporozoite-related antigen (CRA) Ctr PF04145.15 ETO30492.1 - 0.23 12.1 1.3 0.34 11.5 1.3 1.4 1 1 0 1 1 1 0 Ctr copper transporter family RIO1 PF01163.22 ETO30493.1 - 4.7e-43 147.0 0.2 4.7e-43 147.0 0.2 2.5 2 1 0 2 2 2 1 RIO1 family Rio2_N PF09202.11 ETO30493.1 - 7e-22 77.5 1.5 1.1e-20 73.6 0.5 3.1 2 2 0 2 2 2 1 Rio2, N-terminal APH PF01636.23 ETO30493.1 - 5.1e-07 29.8 0.6 0.0052 16.7 0.5 2.8 1 1 1 2 2 2 2 Phosphotransferase enzyme family PIP49_C PF12260.8 ETO30493.1 - 0.027 14.1 0.1 0.027 14.1 0.1 2.2 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 Laminin_II PF06009.12 ETO30494.1 - 0.0039 17.2 10.4 0.0039 17.2 10.4 2.7 1 1 2 3 3 3 1 Laminin Domain II TMF_TATA_bd PF12325.8 ETO30494.1 - 0.038 14.2 29.5 0.2 11.9 17.5 3.2 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding ERM PF00769.19 ETO30494.1 - 0.087 12.6 27.4 0.15 11.9 27.4 1.3 1 0 0 1 1 1 0 Ezrin/radixin/moesin family ATG16 PF08614.11 ETO30494.1 - 0.32 11.2 31.4 0.16 12.2 6.2 2.5 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Lipoprotein_6 PF01441.19 ETO30494.1 - 0.44 10.5 13.1 1.8 8.6 1.3 2.9 2 1 0 2 2 2 0 Lipoprotein WXG100 PF06013.12 ETO30494.1 - 0.46 10.7 11.7 0.35 11.1 3.2 3.2 2 1 0 2 2 2 0 Proteins of 100 residues with WXG GAS PF13851.6 ETO30494.1 - 0.54 9.6 36.9 2.1 7.7 25.1 2.7 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding FapA PF03961.13 ETO30494.1 - 1.6 7.3 29.2 0.98 8.0 13.0 2.3 1 1 1 2 2 2 0 Flagellar Assembly Protein A DUF812 PF05667.11 ETO30494.1 - 1.8 7.4 32.5 0.097 11.5 18.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF812) CENP-F_leu_zip PF10473.9 ETO30494.1 - 3.6 7.6 29.0 24 5.0 11.3 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Seryl_tRNA_N PF02403.22 ETO30494.1 - 6.1 7.1 26.7 15 5.8 4.5 3.8 1 1 2 3 3 3 0 Seryl-tRNA synthetase N-terminal domain DUF641 PF04859.12 ETO30495.1 - 0.026 14.9 0.4 0.026 14.9 0.4 4.2 4 1 0 4 4 4 0 Plant protein of unknown function (DUF641) LapD_MoxY_N PF16448.5 ETO30495.1 - 0.04 13.8 0.2 0.19 11.6 0.2 2.2 1 0 0 1 1 1 0 LapD/MoxY periplasmic domain Complex1_LYR_2 PF13233.6 ETO30495.1 - 5.4 7.8 7.8 2.3 9.0 3.6 2.7 2 0 0 2 2 2 0 Complex1_LYR-like CBFD_NFYB_HMF PF00808.23 ETO30496.1 - 2.4e-12 47.0 0.3 2.4e-11 43.7 0.0 2.2 2 0 0 2 2 2 1 Histone-like transcription factor (CBF/NF-Y) and archaeal histone DUF2272 PF10030.9 ETO30497.1 - 0.049 13.4 0.0 0.058 13.2 0.0 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2272) Pkinase PF00069.25 ETO30498.1 - 5.6e-30 104.6 0.0 1.1e-26 93.9 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30498.1 - 8.5e-29 100.6 0.1 3.3e-28 98.7 0.0 1.9 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO30498.1 - 0.011 15.1 0.0 0.02 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family LSDAT_euk PF18139.1 ETO30499.1 - 0.047 13.1 0.1 0.057 12.8 0.1 1.1 1 0 0 1 1 1 0 SLOG in TRPM ArfGap PF01412.18 ETO30500.1 - 9.2e-30 103.1 0.7 1.9e-29 102.1 0.1 1.7 2 0 0 2 2 2 1 Putative GTPase activating protein for Arf Glyco_hydro_47 PF01532.20 ETO30502.1 - 1.8e-65 221.7 0.4 2e-65 221.5 0.4 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 DUF1724 PF08350.10 ETO30502.1 - 0.0086 16.2 1.3 0.33 11.1 0.1 3.1 3 1 1 4 4 4 1 Domain of unknown function (DUF1724) Glyco_hydro_47 PF01532.20 ETO30503.1 - 1.7e-64 218.4 0.0 2.3e-64 218.0 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Calpain_inhib PF00748.19 ETO30503.1 - 1.2 9.7 11.4 0.035 14.6 5.1 1.6 2 0 0 2 2 2 0 Calpain inhibitor Peptidase_S49 PF01343.18 ETO30504.1 - 8.9e-62 207.6 0.2 6.8e-40 136.5 2.2 3.3 2 1 0 2 2 2 2 Peptidase family S49 SDH_sah PF01972.16 ETO30504.1 - 0.00017 20.7 0.0 0.00082 18.5 0.0 2.0 2 0 0 2 2 2 1 Serine dehydrogenase proteinase CLP_protease PF00574.23 ETO30504.1 - 0.00038 20.4 0.5 0.0017 18.3 0.1 2.4 2 0 0 2 2 2 1 Clp protease Glutaredoxin PF00462.24 ETO30506.1 - 0.0026 17.9 0.2 0.0087 16.3 0.2 1.9 1 0 0 1 1 1 1 Glutaredoxin BLM_N PF16202.5 ETO30506.1 - 0.0094 15.1 2.0 0.013 14.6 2.0 1.1 1 0 0 1 1 1 1 N-terminal region of Bloom syndrome protein GST_N_3 PF13417.6 ETO30506.1 - 0.02 15.3 0.0 0.042 14.3 0.0 1.6 1 0 0 1 1 1 0 Glutathione S-transferase, N-terminal domain GOLD_2 PF13897.6 ETO30506.1 - 0.021 15.3 0.3 0.035 14.6 0.3 1.4 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking Pox_E8 PF03394.13 ETO30506.1 - 0.027 14.0 1.0 0.049 13.2 1.0 1.3 1 0 0 1 1 1 0 Poxvirus E8 protein GST_C PF00043.25 ETO30506.1 - 0.15 12.3 1.1 0.37 11.0 0.0 2.1 2 0 0 2 2 2 0 Glutathione S-transferase, C-terminal domain Ank_2 PF12796.7 ETO30508.1 - 3.8e-58 194.0 0.4 1.5e-13 51.2 0.0 6.2 2 2 4 6 6 6 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO30508.1 - 2e-52 174.9 7.3 6.6e-12 45.7 0.0 7.4 4 1 3 7 7 7 7 Ankyrin repeats (many copies) Ank PF00023.30 ETO30508.1 - 1.3e-50 167.7 7.2 2.4e-06 27.7 0.0 9.1 10 0 0 10 10 10 8 Ankyrin repeat Ank_3 PF13606.6 ETO30508.1 - 2.5e-45 147.2 8.5 2.4e-06 27.4 0.0 9.5 9 0 0 9 9 9 8 Ankyrin repeat Ank_5 PF13857.6 ETO30508.1 - 2.4e-39 132.9 7.7 6.2e-06 26.4 0.0 7.9 4 2 4 8 8 8 7 Ankyrin repeats (many copies) DpnII-MboI PF18742.1 ETO30509.1 - 0.055 13.1 1.9 0.17 11.5 0.6 2.3 2 1 0 2 2 2 0 REase_DpnII-MboI BACK PF07707.15 ETO30509.1 - 1.7 8.8 6.9 4.7 7.4 0.5 2.6 3 0 0 3 3 3 0 BTB And C-terminal Kelch DUF2418 PF10332.9 ETO30510.1 - 1.9 9.1 6.1 4.7 7.8 6.1 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2418) Sigma70_ner PF04546.13 ETO30511.1 - 0.0016 18.3 0.4 0.0016 18.3 0.4 3.0 3 0 0 3 3 3 1 Sigma-70, non-essential region HbrB PF08539.11 ETO30511.1 - 0.07 13.1 2.1 0.59 10.1 0.1 3.1 3 0 0 3 3 3 0 HbrB-like Tim54 PF11711.8 ETO30511.1 - 0.096 11.5 9.5 0.021 13.7 0.5 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 FAM176 PF14851.6 ETO30511.1 - 0.11 12.1 5.9 0.24 11.0 0.1 3.3 2 0 0 2 2 2 0 FAM176 family UPF0239 PF06783.11 ETO30511.1 - 0.78 10.0 0.0 0.78 10.0 0.0 3.3 3 0 0 3 3 3 0 Uncharacterised protein family (UPF0239) H_lectin PF09458.10 ETO30512.1 - 0.087 13.0 0.3 0.21 11.8 0.1 1.8 2 0 0 2 2 2 0 H-type lectin domain NEMO PF11577.8 ETO30513.1 - 0.033 14.2 0.3 0.093 12.8 0.0 1.9 2 0 0 2 2 2 0 NF-kappa-B essential modulator NEMO MARVEL PF01284.23 ETO30514.1 - 0.0005 20.1 0.1 1.4 9.0 0.0 3.3 3 0 0 3 3 3 2 Membrane-associating domain MENTAL PF10457.9 ETO30514.1 - 0.075 12.8 0.2 0.075 12.8 0.2 2.7 3 0 0 3 3 3 0 Cholesterol-capturing domain SNARE PF05739.19 ETO30514.1 - 0.17 11.9 0.1 0.17 11.9 0.1 2.0 2 0 0 2 2 2 0 SNARE domain Chordopox_G3 PF06129.12 ETO30514.1 - 0.36 11.6 0.0 0.36 11.6 0.0 3.3 3 0 0 3 3 3 0 Chordopoxvirus G3 protein GCD14 PF08704.10 ETO30514.1 - 0.67 9.6 9.6 0.66 9.6 1.8 2.2 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit WBP-1 PF11669.8 ETO30514.1 - 0.71 10.5 7.2 1.9 9.2 0.0 3.4 3 1 0 3 3 3 0 WW domain-binding protein 1 Synaptobrevin PF00957.21 ETO30514.1 - 1.7 8.5 8.4 0.73 9.7 1.1 3.3 3 0 0 3 3 3 0 Synaptobrevin CDC45 PF02724.14 ETO30515.1 - 6.5 4.9 10.4 7.2 4.8 10.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DEAD PF00270.29 ETO30516.1 - 1.3e-28 100.0 0.1 2.7e-28 98.9 0.0 1.5 2 0 0 2 2 2 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO30516.1 - 1.1e-16 61.2 0.1 7.5e-14 52.0 0.1 3.0 2 1 1 3 3 3 2 Helicase conserved C-terminal domain CMS1 PF14617.6 ETO30516.1 - 7.8e-06 25.4 0.1 3.6e-05 23.2 0.0 2.0 2 0 0 2 2 2 1 U3-containing 90S pre-ribosomal complex subunit ResIII PF04851.15 ETO30516.1 - 2.8e-05 24.2 0.0 9.6e-05 22.4 0.0 1.8 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit NIF PF03031.18 ETO30516.1 - 0.018 14.8 0.4 0.026 14.3 0.4 1.3 1 0 0 1 1 1 0 NLI interacting factor-like phosphatase RRM_1 PF00076.22 ETO30517.1 - 3.8e-05 23.4 0.4 8.7e-05 22.3 0.4 1.6 1 1 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DUF4927 PF16279.5 ETO30517.1 - 0.15 13.1 0.1 0.24 12.4 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4927) UPF0524 PF15823.5 ETO30518.1 - 0.085 12.2 1.5 0.16 11.3 0.2 2.0 2 0 0 2 2 2 0 UPF0524 of C3orf70 FtsK_gamma PF09397.10 ETO30519.1 - 0.13 12.0 0.0 6.7 6.6 0.0 2.4 2 0 0 2 2 2 0 Ftsk gamma domain DUF4202 PF13875.6 ETO30521.1 - 0.096 12.6 0.2 0.34 10.8 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4202) Macoilin PF09726.9 ETO30522.1 - 0.11 11.0 27.1 0.14 10.7 27.1 1.1 1 0 0 1 1 1 0 Macoilin family Mcp5_PH PF12814.7 ETO30523.1 - 0.012 15.7 2.8 0.025 14.7 1.5 2.2 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology Jak1_Phl PF17887.1 ETO30524.1 - 0.012 15.5 2.9 0.029 14.3 2.9 1.5 1 0 0 1 1 1 0 Jak1 pleckstrin homology-like domain DUF2207 PF09972.9 ETO30524.1 - 0.031 13.1 0.1 0.031 13.1 0.1 1.9 1 1 1 2 2 2 0 Predicted membrane protein (DUF2207) DUF4636 PF15468.6 ETO30524.1 - 0.092 12.4 0.1 0.092 12.4 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4636) PDR_CDR PF06422.12 ETO30524.1 - 0.15 12.0 0.9 0.36 10.8 0.9 1.7 1 0 0 1 1 1 0 CDR ABC transporter RcpC PF16976.5 ETO30524.1 - 0.15 12.1 0.3 0.3 11.1 0.3 1.5 1 0 0 1 1 1 0 Flp pilus assembly protein RcpC/CpaB TRP PF06011.12 ETO30524.1 - 0.26 10.0 18.4 0.15 10.7 15.7 1.8 1 1 1 2 2 2 0 Transient receptor potential (TRP) ion channel Gpr1_Fun34_YaaH PF01184.19 ETO30524.1 - 0.76 9.3 0.0 0.76 9.3 0.0 2.5 2 1 1 3 3 3 0 GPR1/FUN34/yaaH family CH PF00307.31 ETO30525.1 - 7.8e-09 35.7 0.1 1.5e-08 34.8 0.0 1.4 1 1 1 2 2 2 1 Calponin homology (CH) domain zf-RING_2 PF13639.6 ETO30526.1 - 1.7e-11 44.3 6.9 1.7e-11 44.3 6.9 2.4 3 0 0 3 3 1 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO30526.1 - 4.6e-09 36.0 8.2 4.6e-09 36.0 8.2 3.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO30526.1 - 7.6e-09 35.4 4.0 7.6e-09 35.4 4.0 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-rbx1 PF12678.7 ETO30526.1 - 3.5e-08 33.6 5.5 3.5e-08 33.6 5.5 2.4 2 0 0 2 2 2 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO30526.1 - 1.9e-07 30.8 6.7 1.9e-07 30.8 6.7 2.8 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO30526.1 - 2.3e-07 30.4 2.8 2.3e-07 30.4 2.8 2.2 2 0 0 2 2 2 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO30526.1 - 2.4e-07 30.7 4.7 2.4e-07 30.7 4.7 2.5 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO30526.1 - 4.5e-06 26.4 4.3 4.5e-06 26.4 4.3 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO30526.1 - 0.00059 19.8 2.1 0.00059 19.8 2.1 2.8 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO30526.1 - 0.0011 18.8 6.1 0.0075 16.1 6.1 2.4 1 1 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ETO30526.1 - 0.0035 16.9 3.7 0.0035 16.9 3.7 2.3 2 0 0 2 2 2 1 Zinc-ribbon, C4HC2 type AF-4 PF05110.13 ETO30526.1 - 0.0069 14.6 4.2 0.012 13.7 4.2 1.3 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Rad50_zn_hook PF04423.14 ETO30526.1 - 0.075 12.9 1.0 0.15 11.9 1.0 1.4 1 0 0 1 1 1 0 Rad50 zinc hook motif RINGv PF12906.7 ETO30526.1 - 0.18 11.9 4.4 0.84 9.8 4.4 2.3 1 0 0 1 1 1 0 RING-variant domain RNA_polI_A34 PF08208.11 ETO30526.1 - 0.22 11.6 0.1 0.22 11.6 0.1 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 FANCL_C PF11793.8 ETO30526.1 - 0.51 10.6 3.8 2.4 8.4 3.8 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain PHD PF00628.29 ETO30526.1 - 0.71 9.8 3.9 1.6 8.7 3.9 1.7 1 0 0 1 1 1 0 PHD-finger Prok-RING_1 PF14446.6 ETO30526.1 - 8.7 6.4 7.2 11 6.0 3.0 2.5 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 PH PF00169.29 ETO30527.1 - 0.00013 22.5 0.6 0.00026 21.5 0.6 1.6 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO30527.1 - 0.00033 21.0 0.7 0.00033 21.0 0.7 2.5 2 1 0 2 2 2 1 Pleckstrin homology domain SDA1 PF05285.12 ETO30527.1 - 0.003 17.0 13.8 0.003 17.0 13.8 1.5 2 0 0 2 2 2 1 SDA1 V_ATPase_I PF01496.19 ETO30527.1 - 0.14 10.0 2.4 0.17 9.8 2.4 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Nop14 PF04147.12 ETO30527.1 - 0.27 9.4 16.2 0.38 8.9 16.2 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO30527.1 - 0.49 9.1 5.8 0.64 8.7 5.8 1.3 1 0 0 1 1 1 0 Presenilin SpoIIIAH PF12685.7 ETO30527.1 - 0.53 10.1 14.0 0.25 11.2 11.0 1.8 2 0 0 2 2 2 0 SpoIIIAH-like protein CDC45 PF02724.14 ETO30527.1 - 3.1 6.0 15.3 6.6 4.9 15.3 1.5 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO30527.1 - 4.1 5.4 9.5 5.6 4.9 9.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen TFB6 PF17110.5 ETO30527.1 - 4.8 6.9 7.8 3.1 7.5 5.1 2.0 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH RNA_pol_Rpc4 PF05132.14 ETO30527.1 - 6.2 7.2 7.1 1 9.8 3.2 1.7 2 0 0 2 2 2 0 RNA polymerase III RPC4 Ank_2 PF12796.7 ETO30528.1 - 1.3e-48 163.5 14.5 3.9e-10 40.2 0.2 5.7 2 2 5 7 7 7 6 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO30528.1 - 5.6e-39 132.0 6.1 1.3e-09 38.4 0.1 8.9 5 2 4 9 9 9 7 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO30528.1 - 2.6e-27 91.9 3.5 0.045 14.3 0.0 10.3 11 0 0 11 11 11 7 Ankyrin repeat Ank_5 PF13857.6 ETO30528.1 - 4.5e-25 87.4 11.9 8.6e-09 35.5 0.3 6.6 6 1 1 7 7 7 5 Ankyrin repeats (many copies) Ank PF00023.30 ETO30528.1 - 7.3e-25 86.3 0.2 0.00033 21.0 0.0 8.0 8 0 0 8 8 8 6 Ankyrin repeat XK-related PF09815.9 ETO30529.1 - 2.2e-06 27.0 15.6 8.1e-06 25.1 15.4 2.1 1 1 0 1 1 1 1 XK-related protein AmiS_UreI PF02293.15 ETO30529.1 - 0.0099 15.9 3.9 0.0099 15.9 3.9 2.2 2 1 0 2 2 2 1 AmiS/UreI family transporter YgaB PF14182.6 ETO30529.1 - 0.12 12.8 0.1 0.2 12.0 0.1 1.3 1 0 0 1 1 1 0 YgaB-like protein UQ_con PF00179.26 ETO30530.1 - 3.5e-41 140.1 0.8 7.3e-41 139.1 0.2 1.7 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme F-box-like PF12937.7 ETO30530.1 - 2.5e-06 27.3 0.3 6.2e-06 26.0 0.2 1.7 2 0 0 2 2 2 1 F-box-like F-box PF00646.33 ETO30530.1 - 3.1e-06 26.9 0.3 7.3e-06 25.7 0.3 1.5 1 0 0 1 1 1 1 F-box domain RWD PF05773.22 ETO30530.1 - 0.063 13.6 0.0 0.089 13.1 0.0 1.4 1 0 0 1 1 1 0 RWD domain TPR_12 PF13424.6 ETO30532.1 - 3.4e-54 181.1 1.4 1.9e-14 53.7 0.0 4.5 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30532.1 - 5.2e-36 121.0 23.3 6.1e-07 29.0 0.0 6.9 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30532.1 - 8.5e-33 109.8 23.8 1.4e-05 24.9 0.7 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30532.1 - 3.4e-28 96.7 0.0 0.00052 19.8 0.0 6.6 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO30532.1 - 1e-26 91.0 2.3 7.4e-05 22.5 0.0 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO30532.1 - 7.9e-26 88.1 10.4 0.00032 20.6 0.0 7.0 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO30532.1 - 6.4e-17 60.6 5.8 0.0021 18.3 0.1 6.6 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO30532.1 - 1.7e-07 31.4 3.0 5.2 7.9 0.0 6.1 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO30532.1 - 2e-06 28.3 0.0 6.4 7.5 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO30532.1 - 6.5e-05 22.3 12.7 0.1 12.1 0.1 5.5 6 0 0 6 6 6 2 SHNi-TPR TPR_3 PF07720.12 ETO30532.1 - 0.0001 22.2 11.6 1 9.4 0.1 4.8 4 0 0 4 4 4 3 Tetratricopeptide repeat DUF5113 PF17140.4 ETO30532.1 - 0.00011 22.0 11.6 0.026 14.3 3.0 4.4 1 1 3 4 4 4 2 Domain of unknown function (DUF5113) TPR_11 PF13414.6 ETO30532.1 - 0.00033 20.3 24.7 0.27 11.0 0.1 7.3 4 3 3 7 7 7 2 TPR repeat TPR_14 PF13428.6 ETO30532.1 - 0.0004 21.0 0.0 6.2 7.9 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO30532.1 - 0.00049 20.5 0.1 1.1 9.9 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat SPO22 PF08631.10 ETO30532.1 - 0.002 17.7 8.3 0.045 13.2 0.2 3.8 4 1 0 4 4 4 1 Meiosis protein SPO22/ZIP4 like TPR_MalT PF17874.1 ETO30532.1 - 0.01 15.2 0.0 0.036 13.5 0.0 1.7 1 1 0 1 1 1 0 MalT-like TPR region MIT PF04212.18 ETO30532.1 - 0.028 14.5 14.0 3.7 7.7 1.2 4.7 3 2 2 5 5 5 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO30532.1 - 0.9 9.8 10.1 5.3 7.3 0.8 3.8 2 1 0 3 3 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Ubiq-assoc PF09145.10 ETO30532.1 - 2.9 7.9 6.8 42 4.2 0.4 4.1 3 1 0 3 3 3 0 Ubiquitin-associated PRC2_HTH_1 PF18118.1 ETO30533.1 - 0.86 10.4 8.4 1 10.2 7.5 1.6 1 1 1 2 2 2 0 Polycomb repressive complex 2 tri-helical domain ETRAMP PF09716.10 ETO30533.1 - 2.4 8.3 8.7 14 5.8 0.0 2.2 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Katanin_con80 PF13925.6 ETO30534.1 - 0.021 14.8 0.3 0.045 13.8 0.3 1.4 1 0 0 1 1 1 0 con80 domain of Katanin Use1 PF09753.9 ETO30535.1 - 4.6e-14 52.7 0.3 4.6e-14 52.7 0.3 2.4 2 0 0 2 2 2 1 Membrane fusion protein Use1 Macoilin PF09726.9 ETO30535.1 - 0.064 11.8 17.9 0.097 11.2 17.9 1.2 1 0 0 1 1 1 0 Macoilin family Peptidase_M9_N PF08453.10 ETO30535.1 - 0.079 12.7 0.1 0.079 12.7 0.1 2.9 2 1 1 3 3 3 0 Peptidase family M9 N-terminal SNARE PF05739.19 ETO30535.1 - 1.2 9.2 5.3 2.9 7.9 2.4 2.8 1 1 1 2 2 2 0 SNARE domain FAM60A PF15396.6 ETO30535.1 - 3.9 7.4 14.0 1.7 8.6 1.1 2.2 2 0 0 2 2 2 0 Protein Family FAM60A AI-2E_transport PF01594.16 ETO30535.1 - 6.2 5.9 8.1 0.69 9.0 0.3 2.1 2 0 0 2 2 2 0 AI-2E family transporter 4_1_CTD PF05902.13 ETO30535.1 - 8.2 6.6 10.3 0.31 11.1 2.0 2.6 3 0 0 3 3 3 0 4.1 protein C-terminal domain (CTD) ARA70 PF12489.8 ETO30535.1 - 8.7 6.5 17.1 0.084 13.1 7.3 2.5 3 0 0 3 3 3 0 Nuclear coactivator Mucin PF01456.17 ETO30538.1 - 0.0018 18.3 7.3 0.0018 18.3 7.3 2.6 2 1 0 2 2 2 1 Mucin-like glycoprotein SPACA9 PF15120.6 ETO30539.1 - 0.02 14.6 0.3 0.023 14.5 0.3 1.3 1 1 0 1 1 1 0 Sperm acrosome-associated protein 9 Aldedh PF00171.22 ETO30543.1 - 2.8e-31 108.5 0.0 3.6e-31 108.2 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family Aldedh PF00171.22 ETO30544.1 - 1.8e-39 135.5 0.0 2e-39 135.4 0.0 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family PHO4 PF01384.20 ETO30545.1 - 3.7 6.5 6.0 5 6.1 6.0 1.1 1 0 0 1 1 1 0 Phosphate transporter family Phasin PF05597.11 ETO30546.1 - 0.00077 19.5 14.2 0.00077 19.5 14.2 3.3 2 2 2 4 4 4 1 Poly(hydroxyalcanoate) granule associated protein (phasin) ORC5_C PF14630.6 ETO30547.1 - 0.13 11.8 2.2 0.19 11.2 2.2 1.2 1 0 0 1 1 1 0 Origin recognition complex (ORC) subunit 5 C-terminus Hist_deacetyl PF00850.19 ETO30548.1 - 1e-40 140.1 0.7 1.8e-40 139.3 0.0 1.6 2 0 0 2 2 2 1 Histone deacetylase domain CENP-B_dimeris PF09026.10 ETO30549.1 - 1.7e-05 25.1 12.2 4.9e-05 23.7 12.2 1.8 1 0 0 1 1 1 1 Centromere protein B dimerisation domain MOR2-PAG1_C PF14225.6 ETO30549.1 - 0.0071 16.2 2.3 0.014 15.2 2.3 1.4 1 0 0 1 1 1 1 Cell morphogenesis C-terminal Cwf_Cwc_15 PF04889.12 ETO30549.1 - 0.0075 16.0 10.5 0.012 15.3 10.5 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein AOX PF01786.17 ETO30549.1 - 0.016 14.8 0.4 0.039 13.6 0.4 1.6 1 0 0 1 1 1 0 Alternative oxidase CDC45 PF02724.14 ETO30549.1 - 0.038 12.3 6.5 0.059 11.7 6.5 1.2 1 0 0 1 1 1 0 CDC45-like protein RXT2_N PF08595.11 ETO30549.1 - 0.067 13.2 11.4 0.13 12.3 11.4 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal TFIIA PF03153.13 ETO30549.1 - 0.086 12.8 6.2 0.14 12.1 6.2 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit YL1 PF05764.13 ETO30549.1 - 0.22 11.6 12.9 0.37 10.9 12.9 1.3 1 0 0 1 1 1 0 YL1 nuclear protein PPP4R2 PF09184.11 ETO30549.1 - 0.24 11.0 8.6 0.44 10.1 8.6 1.4 1 0 0 1 1 1 0 PPP4R2 Nop14 PF04147.12 ETO30549.1 - 0.33 9.1 11.9 0.49 8.5 11.9 1.2 1 0 0 1 1 1 0 Nop14-like family DUF3295 PF11702.8 ETO30549.1 - 0.6 9.4 10.1 0.95 8.7 10.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3295) Pox_Ag35 PF03286.14 ETO30549.1 - 0.74 9.6 7.4 1.5 8.6 7.4 1.5 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Sporozoite_P67 PF05642.11 ETO30549.1 - 1.9 6.5 5.4 2.6 6.0 5.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SDA1 PF05285.12 ETO30549.1 - 2.1 7.7 12.2 3 7.2 12.2 1.2 1 0 0 1 1 1 0 SDA1 NOA36 PF06524.12 ETO30549.1 - 4.3 6.6 19.7 6.9 5.9 19.7 1.2 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ETO30549.1 - 5.3 6.7 7.7 12 5.5 7.7 1.6 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 ETO30549.1 - 8.7 6.6 13.6 63 3.9 13.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) Serinc PF03348.15 ETO30550.1 - 0.024 13.6 1.7 0.023 13.6 1.7 1.0 1 0 0 1 1 1 0 Serine incorporator (Serinc) DUF4834 PF16118.5 ETO30550.1 - 0.025 15.5 5.6 0.035 15.1 5.6 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Peptidase_S49_N PF08496.10 ETO30550.1 - 0.12 12.5 10.6 0.15 12.1 10.6 1.1 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PRC2_HTH_1 PF18118.1 ETO30550.1 - 0.13 13.0 7.2 0.19 12.6 7.2 1.2 1 0 0 1 1 1 0 Polycomb repressive complex 2 tri-helical domain Nucleoside_tran PF01733.18 ETO30550.1 - 0.18 11.1 1.3 0.21 10.9 1.3 1.0 1 0 0 1 1 1 0 Nucleoside transporter SieB PF14163.6 ETO30550.1 - 0.32 10.5 4.3 0.099 12.1 1.6 1.5 1 1 1 2 2 2 0 Super-infection exclusion protein B HCO3_cotransp PF00955.21 ETO30550.1 - 0.43 9.3 3.1 0.4 9.5 3.1 1.0 1 0 0 1 1 1 0 HCO3- transporter family EOS1 PF12326.8 ETO30550.1 - 0.53 10.2 2.7 0.64 9.9 2.7 1.1 1 0 0 1 1 1 0 N-glycosylation protein SelP_N PF04592.14 ETO30550.1 - 1.7 8.0 10.8 2.3 7.6 10.8 1.3 1 1 0 1 1 1 0 Selenoprotein P, N terminal region Presenilin PF01080.17 ETO30550.1 - 2.5 6.8 5.1 2.8 6.6 5.1 1.1 1 0 0 1 1 1 0 Presenilin DUF1168 PF06658.12 ETO30550.1 - 3.4 7.5 17.1 5 6.9 17.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) O-antigen_lig PF13425.6 ETO30550.1 - 5.8 5.6 7.4 6.8 5.4 7.4 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Pkinase PF00069.25 ETO30551.1 - 6.5e-06 25.7 0.0 8.5e-06 25.3 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO30552.1 - 8.6e-58 195.8 1.9 9.8e-57 192.3 1.9 2.2 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30552.1 - 1e-41 142.9 0.2 2.1e-41 141.9 0.2 1.5 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO30552.1 - 2.5e-08 33.6 0.0 4.8e-08 32.7 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO30552.1 - 4.8e-05 23.4 0.1 0.00024 21.1 0.1 1.9 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO30552.1 - 9.9e-05 21.8 0.8 9.9e-05 21.8 0.8 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO30552.1 - 0.0029 17.2 0.2 0.0029 17.2 0.2 2.0 2 1 0 2 2 2 1 Choline/ethanolamine kinase Haspin_kinase PF12330.8 ETO30552.1 - 0.0032 16.4 0.9 0.0053 15.8 0.9 1.3 1 0 0 1 1 1 1 Haspin like kinase domain SR-25 PF10500.9 ETO30552.1 - 0.0036 16.9 15.5 0.0058 16.3 15.5 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Seadorna_VP7 PF07387.11 ETO30552.1 - 0.087 11.9 0.5 0.38 9.8 0.0 1.9 2 0 0 2 2 2 0 Seadornavirus VP7 NPR3 PF03666.13 ETO30552.1 - 0.12 11.1 9.7 0.23 10.2 9.7 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF1345 PF07077.11 ETO30552.1 - 0.14 11.8 0.2 1.2 8.8 0.0 2.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1345) Presenilin PF01080.17 ETO30552.1 - 0.83 8.4 9.1 1.2 7.8 9.1 1.3 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO30552.1 - 2.8 6.1 12.7 4 5.6 12.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Tir_receptor_C PF07489.11 ETO30552.1 - 9.6 6.1 9.2 0.14 12.1 0.5 2.0 2 0 0 2 2 2 0 Translocated intimin receptor (Tir) C-terminus GPCR_chapero_1 PF11904.8 ETO30553.1 - 2.5e-33 115.8 24.1 2.1e-30 106.3 24.1 2.2 1 1 0 1 1 1 1 GPCR-chaperone YCII PF03795.14 ETO30553.1 - 0.072 13.5 0.1 0.16 12.4 0.1 1.6 1 0 0 1 1 1 0 YCII-related domain YTH PF04146.15 ETO30554.1 - 4.8e-09 36.4 0.0 4.8e-09 36.4 0.0 3.1 2 1 0 2 2 2 1 YT521-B-like domain Utp14 PF04615.13 ETO30554.1 - 7.3 5.0 40.5 9.3 4.7 40.5 1.1 1 0 0 1 1 1 0 Utp14 protein Spore_III_AB PF09548.10 ETO30555.1 - 0.0078 16.3 0.0 0.014 15.5 0.0 1.4 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) PhaP_Bmeg PF09602.10 ETO30555.1 - 0.011 15.7 0.7 0.23 11.4 0.0 2.1 2 0 0 2 2 2 0 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DSPc PF00782.20 ETO30556.1 - 6.2e-22 77.8 0.0 9.4e-22 77.3 0.0 1.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ETO30556.1 - 0.00026 21.3 0.0 0.00043 20.6 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ETO30556.1 - 0.013 15.0 0.1 0.022 14.3 0.0 1.4 1 1 0 1 1 1 0 Protein-tyrosine phosphatase DUF1877 PF08974.10 ETO30556.1 - 0.05 13.7 0.6 0.27 11.3 0.0 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF1877) Y_phosphatase3 PF13350.6 ETO30556.1 - 0.071 13.1 0.0 0.092 12.7 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family Croc_4 PF17691.1 ETO30557.1 - 0.13 12.3 0.0 0.18 11.8 0.0 1.2 1 0 0 1 1 1 0 Contingent replication of cDNA 4 TPH PF13868.6 ETO30558.1 - 0.0037 15.8 28.3 0.0037 15.8 28.3 3.1 2 1 0 2 2 2 2 Trichohyalin-plectin-homology domain Cyto_heme_lyase PF01265.17 ETO30559.1 - 2.4e-10 40.5 1.7 4.6e-10 39.6 1.7 1.4 1 1 0 1 1 1 1 Cytochrome c/c1 heme lyase ADK PF00406.22 ETO30560.1 - 3.6e-52 176.5 0.2 6.4e-52 175.7 0.2 1.4 1 1 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETO30560.1 - 1.1e-19 71.2 0.1 4.5e-19 69.2 0.0 1.8 2 0 0 2 2 2 1 AAA domain ADK_lid PF05191.14 ETO30560.1 - 1.4e-16 60.1 0.1 3.1e-16 59.0 0.1 1.6 1 0 0 1 1 1 1 Adenylate kinase, active site lid HD-ZIP_N PF04618.12 ETO30563.1 - 0.022 15.3 1.7 0.034 14.7 1.7 1.3 1 0 0 1 1 1 0 HD-ZIP protein N terminus Spt20 PF12090.8 ETO30563.1 - 0.15 11.7 14.3 0.19 11.3 14.3 1.2 1 0 0 1 1 1 0 Spt20 family RLL PF10036.9 ETO30563.1 - 0.18 11.6 6.9 11 5.8 6.5 2.0 1 1 1 2 2 2 0 RNA transcription, translation and transport factor protein Neur_chan_memb PF02932.16 ETO30563.1 - 1.1 9.3 4.3 1.4 8.9 4.3 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO30563.1 - 1.4 7.6 4.2 1.7 7.4 4.2 1.1 1 0 0 1 1 1 0 Presenilin zf-C2HC_2 PF13913.6 ETO30565.1 - 1.5e-15 56.7 7.7 1.1e-09 37.9 1.2 2.5 2 0 0 2 2 2 2 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 ETO30565.1 - 1.5e-05 25.1 0.4 0.038 14.4 0.1 2.8 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO30565.1 - 5.2e-05 23.7 4.0 0.02 15.7 0.4 2.7 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_11 PF16622.5 ETO30565.1 - 0.00026 20.7 0.3 0.0032 17.2 0.0 2.3 2 0 0 2 2 2 1 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ETO30565.1 - 0.0015 18.7 2.5 0.019 15.3 0.4 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding O-antigen_lig PF13425.6 ETO30565.1 - 0.0062 15.4 0.2 0.0062 15.4 0.2 3.6 3 1 0 3 3 2 1 O-antigen ligase like membrane protein zinc_ribbon_2 PF13240.6 ETO30565.1 - 0.052 13.3 2.3 0.53 10.1 0.1 3.0 2 0 0 2 2 2 0 zinc-ribbon domain DUF2304 PF10066.9 ETO30565.1 - 0.11 12.7 0.4 0.11 12.7 0.4 3.6 4 1 0 5 5 4 0 Uncharacterized conserved protein (DUF2304) AP_endonuc_2 PF01261.24 ETO30565.1 - 0.17 11.3 0.0 0.45 9.9 0.0 1.7 2 0 0 2 2 2 0 Xylose isomerase-like TIM barrel zf-C2H2_2 PF12756.7 ETO30565.1 - 0.17 12.2 3.8 5 7.5 1.0 3.3 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) zf-CHCC PF10276.9 ETO30565.1 - 0.21 11.6 6.1 0.19 11.8 0.4 2.3 2 0 0 2 2 2 0 Zinc-finger domain zf-H2C2_2 PF13465.6 ETO30565.1 - 0.47 11.0 4.3 4.8 7.8 0.1 2.8 2 0 0 2 2 2 0 Zinc-finger double domain zf_UBZ PF18439.1 ETO30565.1 - 0.5 10.0 1.7 11 5.7 0.3 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-C2H2_6 PF13912.6 ETO30565.1 - 0.51 10.4 6.2 0.52 10.4 1.5 2.4 2 0 0 2 2 2 0 C2H2-type zinc finger SOG2 PF10428.9 ETO30565.1 - 0.9 8.7 29.8 0.35 10.0 18.7 2.4 2 0 0 2 2 2 0 RAM signalling pathway protein HypA PF01155.19 ETO30565.1 - 1.3 9.0 6.1 15 5.6 0.4 2.4 2 0 0 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA DUF4599 PF15371.6 ETO30565.1 - 2.4 8.7 8.4 1.8 9.2 1.4 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4599) DEP PF00610.21 ETO30566.1 - 0.0026 17.8 0.0 0.012 15.7 0.0 2.0 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CENP-B_dimeris PF09026.10 ETO30566.1 - 9.8 6.6 14.5 9.7 6.7 12.2 2.2 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Sporozoite_P67 PF05642.11 ETO30566.1 - 9.9 4.1 21.8 0.42 8.7 1.5 2.3 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Nop14 PF04147.12 ETO30568.1 - 4.2e-06 25.3 5.2 5.2e-06 25.0 5.2 1.0 1 0 0 1 1 1 1 Nop14-like family RCR PF12273.8 ETO30568.1 - 0.68 10.6 6.4 0.23 12.1 0.6 2.7 2 1 0 2 2 2 0 Chitin synthesis regulation, resistance to Congo red Mannosyl_trans3 PF11051.8 ETO30569.1 - 2e-13 50.4 0.2 2.7e-13 49.9 0.2 1.2 1 0 0 1 1 1 1 Mannosyltransferase putative TPR_MLP1_2 PF07926.12 ETO30570.1 - 0.019 15.0 13.9 0.019 15.0 13.9 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Telomere_reg-2 PF10193.9 ETO30571.1 - 1.3 9.5 7.9 1.2 9.6 4.2 2.4 2 0 0 2 2 2 0 Telomere length regulation protein STAT_alpha PF01017.20 ETO30571.1 - 5.3 6.9 31.7 0.053 13.4 20.1 2.6 1 1 2 3 3 3 0 STAT protein, all-alpha domain CENP-B_dimeris PF09026.10 ETO30573.1 - 0.042 14.2 3.9 0.074 13.5 3.9 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain CD34_antigen PF06365.12 ETO30575.1 - 3.3 7.2 14.9 0.19 11.3 2.5 3.2 1 1 1 3 3 3 0 CD34/Podocalyxin family HEAT PF02985.22 ETO30577.1 - 8.4e-08 31.8 0.2 0.041 14.1 0.3 4.8 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ETO30577.1 - 0.0033 17.8 0.3 4.6 7.7 0.0 3.1 2 1 1 3 3 3 2 HEAT repeats Cnd1 PF12717.7 ETO30577.1 - 0.016 15.2 6.9 1.7 8.7 0.3 3.9 4 0 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO30577.1 - 0.029 14.9 1.6 1.7 9.3 0.0 3.5 3 0 0 3 3 3 0 Vacuolar 14 Fab1-binding region PT PF04886.12 ETO30578.1 - 3.6e-08 32.8 155.8 1.8e+04 -5.0 56.1 7.9 1 1 1 2 2 2 0 PT repeat TFIIA PF03153.13 ETO30578.1 - 1.8 8.5 14.9 2.6 8.0 14.9 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Sox_N PF12444.8 ETO30579.1 - 0.27 12.4 1.5 0.35 12.0 1.5 1.4 1 1 0 1 1 1 0 Sox developmental protein N terminal EF-hand_1 PF00036.32 ETO30580.1 - 1e-25 87.3 18.6 1.2e-08 33.9 0.9 5.0 4 1 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO30580.1 - 4.2e-25 88.0 12.1 2e-15 57.0 1.2 2.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO30580.1 - 2.9e-21 73.5 9.6 2.9e-07 29.9 0.2 4.2 3 1 1 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 ETO30580.1 - 5.8e-19 67.7 17.0 1.2e-11 44.2 1.9 4.4 2 2 2 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO30580.1 - 1.3e-15 56.1 12.7 3.5e-05 23.1 0.6 4.1 4 0 0 4 4 4 3 EF hand EF-hand_9 PF14658.6 ETO30580.1 - 4e-12 46.3 0.5 5.6e-06 26.6 0.1 2.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_14 PF17959.1 ETO30580.1 - 0.00014 22.1 3.8 0.12 12.7 0.2 2.4 1 1 1 2 2 2 2 EF-hand domain Cytochrome_CBB3 PF13442.6 ETO30580.1 - 0.00017 21.8 0.2 0.022 15.0 0.0 2.3 2 0 0 2 2 2 1 Cytochrome C oxidase, cbb3-type, subunit III EF-hand_4 PF12763.7 ETO30580.1 - 0.0003 20.7 7.9 0.0033 17.3 1.3 2.9 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand SurA_N_2 PF13623.6 ETO30580.1 - 0.00064 19.6 6.1 0.086 12.7 0.6 2.3 1 1 1 2 2 2 2 SurA N-terminal domain SPARC_Ca_bdg PF10591.9 ETO30580.1 - 0.00076 19.8 4.4 0.037 14.4 0.2 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region Caleosin PF05042.13 ETO30580.1 - 0.001 19.0 1.0 0.37 10.7 0.0 2.8 1 1 2 3 3 3 1 Caleosin related protein TerB PF05099.13 ETO30580.1 - 0.0073 16.3 1.4 0.019 14.9 0.4 1.9 1 1 2 3 3 3 1 Tellurite resistance protein TerB SurA_N_3 PF13624.6 ETO30580.1 - 0.0098 15.7 4.3 0.012 15.4 1.3 2.1 1 1 0 2 2 2 1 SurA N-terminal domain RTX_C PF08339.10 ETO30580.1 - 0.016 15.3 3.2 0.68 10.0 0.4 2.1 1 1 1 2 2 2 0 RTX C-terminal domain LEM PF03020.15 ETO30580.1 - 0.031 13.8 0.4 5.9 6.5 0.0 2.7 2 0 0 2 2 2 0 LEM domain Toprim PF01751.22 ETO30580.1 - 0.083 13.1 0.4 2.4 8.4 0.0 2.3 1 1 1 2 2 2 0 Toprim domain DUF3349 PF11829.8 ETO30580.1 - 0.088 13.6 1.0 1.9 9.3 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) Cytochrom_C PF00034.21 ETO30580.1 - 0.11 13.6 1.2 20 6.4 0.1 2.3 2 0 0 2 2 2 0 Cytochrome c DUF592 PF04574.13 ETO30580.1 - 0.12 12.1 0.6 0.28 10.9 0.5 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF592) Dockerin_1 PF00404.18 ETO30580.1 - 0.12 12.5 4.6 7.2 6.9 1.5 3.1 1 1 3 4 4 4 0 Dockerin type I domain MgtE_N PF03448.17 ETO30580.1 - 0.19 12.3 5.1 0.15 12.7 1.5 2.1 1 1 1 2 2 2 0 MgtE intracellular N domain Glycos_trans_3N PF02885.17 ETO30580.1 - 0.22 11.4 1.8 12 5.8 0.1 3.0 2 2 1 3 3 3 0 Glycosyl transferase family, helical bundle domain DUF1456 PF07308.13 ETO30580.1 - 0.33 11.3 3.8 3.2 8.2 0.2 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1456) RNA_pol_Rpb4 PF03874.16 ETO30580.1 - 0.38 11.1 3.4 1.5 9.1 0.2 2.5 2 1 0 2 2 2 0 RNA polymerase Rpb4 CMS1 PF14617.6 ETO30580.1 - 1.2 8.4 5.6 0.3 10.4 1.1 1.9 1 1 1 2 2 2 0 U3-containing 90S pre-ribosomal complex subunit DUF1690 PF07956.11 ETO30580.1 - 2.9 8.3 5.9 20 5.6 1.2 2.1 1 1 1 2 2 2 0 Protein of Unknown function (DUF1690) ribosomal_L24 PF17136.4 ETO30584.1 - 2.3e-05 24.7 0.3 0.00011 22.5 0.0 2.3 2 0 0 2 2 2 1 Ribosomal proteins 50S L24/mitochondrial 39S L24 KOW PF00467.29 ETO30584.1 - 6.6e-05 22.7 1.4 6.6e-05 22.7 1.4 2.1 2 0 0 2 2 2 1 KOW motif WD40 PF00400.32 ETO30585.1 - 3.5e-127 410.6 54.8 1.8e-08 34.9 0.0 15.6 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30585.1 - 2.9e-24 85.2 10.1 0.0094 16.2 0.1 11.6 2 2 9 12 12 12 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO30585.1 - 2.2e-10 40.4 4.7 0.13 11.6 0.1 6.5 4 2 1 6 6 6 4 WD40-like domain Ge1_WD40 PF16529.5 ETO30585.1 - 4.8e-10 38.9 10.1 1.4 7.9 0.0 10.6 3 3 9 13 13 13 2 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO30585.1 - 1.4e-08 34.9 0.0 2.9e-08 33.8 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO30585.1 - 1.4e-06 27.9 2.8 2.7e-06 26.9 2.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Nup160 PF11715.8 ETO30585.1 - 1.5e-05 23.9 29.8 2.3 6.8 0.0 10.8 4 4 9 13 13 13 4 Nucleoporin Nup120/160 Pentapeptide_4 PF13599.6 ETO30585.1 - 0.00034 20.7 0.2 0.00087 19.4 0.2 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO30585.1 - 0.0019 18.3 0.5 0.0053 16.9 0.5 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO30585.1 - 0.0035 15.9 6.3 0.72 8.3 0.0 4.8 3 1 2 5 5 5 1 Cytochrome D1 heme domain AAA_18 PF13238.6 ETO30585.1 - 0.0056 17.2 0.1 0.043 14.4 0.0 2.5 1 1 1 2 2 2 1 AAA domain DUF3294 PF07957.11 ETO30585.1 - 0.0087 15.8 1.5 0.41 10.4 0.2 2.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3294) AAA_22 PF13401.6 ETO30585.1 - 0.0094 16.2 0.0 0.037 14.3 0.0 2.0 1 1 0 1 1 1 1 AAA domain PQQ_2 PF13360.6 ETO30585.1 - 0.1 12.1 1.3 3.6 7.1 0.1 3.3 2 1 1 3 3 3 0 PQQ-like domain Gmad1 PF10647.9 ETO30585.1 - 0.29 10.8 0.7 6.6 6.4 0.1 3.2 3 1 0 3 3 3 0 Lipoprotein LpqB beta-propeller domain PD40 PF07676.12 ETO30585.1 - 4.6 7.3 13.9 91 3.2 0.1 6.8 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat Pkinase PF00069.25 ETO30586.1 - 1.9e-23 83.2 0.0 2.2e-23 83.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30586.1 - 1.9e-07 30.7 0.0 2.5e-07 30.3 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_C PF00433.24 ETO30586.1 - 4.9e-05 23.9 2.3 9.9e-05 23.0 2.3 1.5 1 0 0 1 1 1 1 Protein kinase C terminal domain VWA PF00092.28 ETO30587.1 - 2.2e-07 31.3 2.3 1.8e-05 25.1 1.1 3.0 2 1 0 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.6 ETO30587.1 - 9.6e-06 25.6 0.2 0.058 13.3 0.1 2.7 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA_2 PF13519.6 ETO30587.1 - 0.0001 22.9 1.2 0.0012 19.4 0.0 2.9 2 0 0 2 2 2 1 von Willebrand factor type A domain Glyco_transf_92 PF01697.27 ETO30588.1 - 8e-24 84.7 2.3 1.4e-23 83.9 2.3 1.3 1 0 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO30588.1 - 1.1e-06 29.1 0.0 5e-06 26.9 0.0 2.1 1 1 0 1 1 1 1 Glycosyl transferase family 2 DUF3081 PF11280.8 ETO30588.1 - 0.11 12.3 0.2 5.4 6.9 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3081) Ribosomal_S13_N PF08069.12 ETO30588.1 - 0.14 12.2 0.0 0.3 11.2 0.0 1.5 1 0 0 1 1 1 0 Ribosomal S13/S15 N-terminal domain Macoilin PF09726.9 ETO30589.1 - 0.6 8.6 9.5 0.75 8.3 9.5 1.1 1 0 0 1 1 1 0 Macoilin family BSP_II PF05432.11 ETO30589.1 - 4.7 6.8 18.1 2.2 7.9 5.4 2.2 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) WD40 PF00400.32 ETO30590.1 - 3.7e-43 144.7 18.1 7.8e-08 32.9 0.4 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30590.1 - 1.6e-10 41.2 2.2 0.28 11.5 0.0 5.5 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO30590.1 - 8.6e-10 37.9 5.9 0.15 10.7 0.0 5.2 2 2 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO30590.1 - 0.00021 20.7 2.2 0.97 8.7 0.0 4.1 2 2 2 4 4 4 2 WD40-like domain BBS2_Mid PF14783.6 ETO30590.1 - 0.0091 16.0 2.5 0.35 10.9 0.2 4.0 2 1 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region Nucleoporin_N PF08801.11 ETO30590.1 - 0.044 12.5 2.0 2.5 6.8 0.1 3.8 2 1 3 5 5 5 0 Nup133 N terminal like ProRS-C_1 PF09180.11 ETO30590.1 - 0.083 13.1 0.1 0.64 10.3 0.0 2.4 1 1 1 2 2 2 0 Prolyl-tRNA synthetase, C-terminal DUF2415 PF10313.9 ETO30590.1 - 0.22 11.5 1.6 10 6.2 0.1 3.1 3 0 0 3 3 3 0 Uncharacterised protein domain (DUF2415) Sec34 PF04136.15 ETO30590.1 - 0.76 9.6 3.7 1.1 9.1 3.7 1.2 1 0 0 1 1 1 0 Sec34-like family COX7a PF02238.15 ETO30592.1 - 2.8 8.4 5.6 37 4.8 0.1 3.7 4 0 0 4 4 4 0 Cytochrome c oxidase subunit VII BUD22 PF09073.10 ETO30594.1 - 0.027 13.8 32.3 0.028 13.8 32.3 1.0 1 0 0 1 1 1 0 BUD22 BAF1_ABF1 PF04684.13 ETO30594.1 - 0.51 9.3 22.4 0.57 9.2 22.4 1.0 1 0 0 1 1 1 0 BAF1 / ABF1 chromatin reorganising factor ATP-synt_B PF00430.18 ETO30594.1 - 0.81 9.8 11.1 1.2 9.3 11.1 1.3 1 0 0 1 1 1 0 ATP synthase B/B' CF(0) Mem_trans PF03547.18 ETO30594.1 - 6.5 5.0 4.8 6.8 5.0 4.8 1.2 1 0 0 1 1 1 0 Membrane transport protein CENP-B_dimeris PF09026.10 ETO30594.1 - 9.3 6.7 22.8 2 8.9 4.3 2.3 2 0 0 2 2 2 0 Centromere protein B dimerisation domain FancD2 PF14631.6 ETO30594.1 - 9.4 3.5 14.6 11 3.2 14.6 1.1 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease BioW PF03744.13 ETO30595.1 - 0.14 11.6 0.0 0.23 11.0 0.0 1.2 1 0 0 1 1 1 0 6-carboxyhexanoate--CoA ligase MaAIMP_sms PF16951.5 ETO30595.1 - 0.16 11.8 0.3 0.42 10.4 0.3 1.7 1 0 0 1 1 1 0 Putative methionine and alanine importer, small subunit DnaJ_C PF01556.18 ETO30596.1 - 3.4e-43 147.3 0.2 4.8e-43 146.8 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO30596.1 - 1e-11 45.0 12.4 2.7e-11 43.6 12.4 1.8 1 0 0 1 1 1 1 DnaJ central domain Vps39_2 PF10367.9 ETO30596.1 - 0.02 15.3 2.1 0.73 10.3 0.0 2.7 2 0 0 2 2 2 0 Vacuolar sorting protein 39 domain 2 SCFA_trans PF02667.14 ETO30596.1 - 0.16 10.9 1.1 0.29 10.1 1.1 1.3 1 0 0 1 1 1 0 Short chain fatty acid transporter HypA PF01155.19 ETO30596.1 - 4.9 7.2 11.4 4.1 7.4 1.1 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA PS_Dcarbxylase PF02666.15 ETO30597.1 - 4.4e-52 176.6 0.0 3.3e-51 173.7 0.0 2.2 2 0 0 2 2 2 1 Phosphatidylserine decarboxylase C2 PF00168.30 ETO30597.1 - 8.7e-30 103.1 0.2 4.7e-19 68.6 0.0 2.5 2 0 0 2 2 2 2 C2 domain EF-hand_6 PF13405.6 ETO30597.1 - 1.9e-07 30.4 0.7 0.012 15.5 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain EF-hand_1 PF00036.32 ETO30597.1 - 0.00054 19.3 1.3 0.0037 16.7 0.0 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO30597.1 - 0.035 14.6 0.8 0.087 13.3 0.8 1.7 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_8 PF13833.6 ETO30597.1 - 0.059 13.2 0.0 0.29 11.0 0.0 2.1 2 0 0 2 2 2 0 EF-hand domain pair EF-hand_5 PF13202.6 ETO30597.1 - 0.22 11.1 0.0 0.22 11.1 0.0 1.9 2 0 0 2 2 2 0 EF hand Kinesin PF00225.23 ETO30598.1 - 1.4e-18 66.9 0.1 1.4e-18 66.9 0.1 2.9 2 1 0 2 2 2 1 Kinesin motor domain FMN_dh PF01070.18 ETO30601.1 - 1.3e-110 369.7 0.4 2.3e-110 368.9 0.4 1.3 1 0 0 1 1 1 1 FMN-dependent dehydrogenase Cyt-b5 PF00173.28 ETO30601.1 - 7.1e-19 67.7 0.1 2.2e-18 66.2 0.0 1.9 2 0 0 2 2 2 1 Cytochrome b5-like Heme/Steroid binding domain Glu_synthase PF01645.17 ETO30601.1 - 1.1e-09 37.9 0.2 2e-09 37.0 0.2 1.4 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ETO30601.1 - 7.5e-07 28.5 1.2 1.2e-05 24.5 0.5 2.3 1 1 1 2 2 2 1 IMP dehydrogenase / GMP reductase domain NMO PF03060.15 ETO30601.1 - 3.5e-05 23.4 0.3 7.1e-05 22.3 0.3 1.4 1 0 0 1 1 1 1 Nitronate monooxygenase His_biosynth PF00977.21 ETO30601.1 - 0.029 13.8 0.2 0.074 12.5 0.1 1.7 1 1 0 1 1 1 0 Histidine biosynthesis protein Peptidase_C1 PF00112.23 ETO30602.1 - 7.4e-05 22.9 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 Papain family cysteine protease zf-C2H2_4 PF13894.6 ETO30602.1 - 0.0066 17.2 1.1 4.7 8.3 0.1 2.9 2 0 0 2 2 2 2 C2H2-type zinc finger zf-RING_UBOX PF13445.6 ETO30602.1 - 0.077 13.0 0.6 1.7 8.7 0.2 2.6 2 0 0 2 2 2 0 RING-type zinc-finger zf_UBZ PF18439.1 ETO30602.1 - 0.11 12.1 0.3 0.83 9.3 0.0 2.3 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger zf-Di19 PF05605.12 ETO30602.1 - 0.19 12.1 2.1 1.6 9.1 2.1 2.2 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-H2C2_2 PF13465.6 ETO30602.1 - 0.19 12.2 2.6 0.81 10.2 0.2 2.6 2 0 0 2 2 2 0 Zinc-finger double domain Zn-ribbon_8 PF09723.10 ETO30602.1 - 0.22 11.7 1.7 0.6 10.3 1.0 2.2 2 0 0 2 2 2 0 Zinc ribbon domain Cys_rich_CPCC PF14206.6 ETO30602.1 - 0.3 10.9 2.6 0.43 10.4 0.2 2.5 3 0 0 3 3 3 0 Cysteine-rich CPCC zf-C2H2 PF00096.26 ETO30602.1 - 2.1 9.0 5.4 13 6.5 0.8 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type Zn-C2H2_12 PF18112.1 ETO30602.1 - 3.1 8.4 5.0 2 9.0 0.9 2.4 2 0 0 2 2 2 0 Autophagy receptor zinc finger-C2H2 domain VWA PF00092.28 ETO30603.1 - 3.2e-07 30.8 0.0 1.2e-05 25.6 0.0 2.9 2 1 1 3 3 3 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO30603.1 - 0.00025 21.7 0.0 0.54 10.9 0.0 3.0 2 1 0 3 3 3 2 von Willebrand factor type A domain DUF1194 PF06707.11 ETO30603.1 - 0.0019 17.4 0.0 0.0048 16.1 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF1194) VWA_CoxE PF05762.14 ETO30603.1 - 0.041 13.3 0.0 5.3 6.4 0.0 2.3 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein VWA_3 PF13768.6 ETO30603.1 - 0.045 13.7 0.0 0.3 11.0 0.0 2.3 2 1 1 3 3 3 0 von Willebrand factor type A domain PilJ_C PF18223.1 ETO30603.1 - 0.15 12.6 0.0 4.2 7.9 0.0 2.8 3 0 0 3 3 3 0 Pili PilJ C-terminal domain RGS PF00615.19 ETO30604.1 - 7.9e-06 26.1 0.9 0.047 14.0 0.1 2.3 2 0 0 2 2 2 2 Regulator of G protein signaling domain Exo_endo_phos PF03372.23 ETO30607.1 - 7.3e-06 25.7 0.0 3.9e-05 23.3 0.0 1.8 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TAXi_N PF14543.6 ETO30609.1 - 1.2e-19 71.3 1.0 3e-19 69.9 1.0 1.6 1 1 0 1 1 1 1 Xylanase inhibitor N-terminal PTP_tm PF18861.1 ETO30610.1 - 0.087 12.8 0.0 0.28 11.1 0.0 1.8 1 1 1 2 2 2 0 Transmembrane domain of protein tyrosine phosphatase, receptor type J DNA_pol_D_N PF18018.1 ETO30611.1 - 2e-31 108.8 0.4 2.6e-31 108.4 0.4 1.2 1 0 0 1 1 1 1 DNA polymerase delta subunit OB-fold domain Sds3 PF08598.11 ETO30611.1 - 0.034 14.1 0.1 0.041 13.9 0.1 1.1 1 0 0 1 1 1 0 Sds3-like DUF3161 PF11362.8 ETO30612.1 - 0.018 15.0 0.1 0.36 10.8 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3161) Endonuc_Holl PF10107.9 ETO30612.1 - 0.43 10.4 2.9 0.18 11.6 0.2 1.7 2 0 0 2 2 2 0 Endonuclease related to archaeal Holliday junction resolvase DUF3262 PF11660.8 ETO30615.1 - 0.23 11.9 2.0 0.26 11.7 0.3 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3262) DUF4718 PF15842.5 ETO30616.1 - 0.043 13.6 1.3 0.055 13.3 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) DUF3713 PF12506.8 ETO30616.1 - 0.56 10.5 7.3 0.56 10.5 2.6 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3713) Jnk-SapK_ap_N PF09744.9 ETO30616.1 - 1.2 9.3 16.2 5.6 7.2 10.1 2.3 1 1 0 2 2 2 0 JNK_SAPK-associated protein-1 DUF4061 PF13270.6 ETO30616.1 - 2.4 8.5 9.5 0.35 11.2 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4061) bZIP_1 PF00170.21 ETO30616.1 - 4.7 7.4 15.8 0.58 10.3 1.4 3.1 2 1 1 3 3 3 0 bZIP transcription factor E1_dh PF00676.20 ETO30617.1 - 5.7e-52 176.5 6.2 2.3e-46 158.1 0.4 2.0 2 0 0 2 2 2 2 Dehydrogenase E1 component DUF687 PF05095.12 ETO30618.1 - 0.0066 15.0 0.1 0.0081 14.7 0.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF687) tRNA_bind_2 PF13725.6 ETO30618.1 - 0.13 12.0 0.1 0.2 11.3 0.1 1.2 1 0 0 1 1 1 0 Possible tRNA binding domain ubiquitin PF00240.23 ETO30619.1 - 2.6e-09 36.7 0.1 6e-09 35.5 0.1 1.7 2 1 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ETO30619.1 - 0.00039 20.2 0.0 0.00066 19.5 0.0 1.5 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Swi6_N PF18530.1 ETO30620.1 - 0.0037 17.4 1.4 0.0047 17.0 0.2 1.9 2 0 0 2 2 2 1 Swi6 N-terminal domain Latrophilin PF02354.16 ETO30620.1 - 0.026 13.6 0.2 0.029 13.5 0.2 1.1 1 0 0 1 1 1 0 Latrophilin Cytoplasmic C-terminal region SPG4 PF17325.2 ETO30620.1 - 0.073 14.2 3.6 0.11 13.6 3.6 1.3 1 0 0 1 1 1 0 Stationary phase protein 4 Paralemmin PF03285.15 ETO30620.1 - 1 8.8 10.5 1.4 8.4 10.5 1.1 1 0 0 1 1 1 0 Paralemmin Na_H_Exchanger PF00999.21 ETO30621.1 - 1.8e-32 112.6 7.9 2.1e-32 112.4 7.9 1.0 1 0 0 1 1 1 1 Sodium/hydrogen exchanger family DUF3273 PF11677.8 ETO30621.1 - 0.0056 16.0 1.7 0.0056 16.0 1.7 1.5 2 0 0 2 2 2 1 Protein of unknown function (DUF3273) FecCD PF01032.18 ETO30621.1 - 0.31 10.0 7.4 0.035 13.1 2.6 1.8 2 0 0 2 2 2 0 FecCD transport family EF-hand_1 PF00036.32 ETO30623.1 - 1.1e-12 46.5 6.7 8.6e-05 21.8 0.6 3.4 3 0 0 3 3 3 3 EF hand EF-hand_7 PF13499.6 ETO30623.1 - 5e-10 39.7 6.8 0.00037 20.9 3.8 3.1 2 1 1 3 3 3 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO30623.1 - 6.9e-10 38.1 1.6 0.00036 20.2 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_8 PF13833.6 ETO30623.1 - 3.2e-07 30.1 6.1 0.0011 18.7 0.1 3.2 3 0 0 3 3 3 3 EF-hand domain pair EF-hand_4 PF12763.7 ETO30623.1 - 0.0013 18.7 5.8 0.0073 16.2 0.1 2.7 1 1 2 3 3 3 1 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO30623.1 - 0.014 15.8 1.1 0.2 12.0 0.1 2.2 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO30623.1 - 0.7 9.5 8.7 0.42 10.2 1.1 3.3 3 0 0 3 3 3 0 EF hand FAD_binding_6 PF00970.24 ETO30626.1 - 9e-27 93.3 0.0 1.7e-26 92.4 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ETO30626.1 - 1e-26 93.7 0.0 4.7e-26 91.6 0.0 2.1 2 0 0 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETO30626.1 - 2.2e-08 34.4 0.0 2.6e-06 27.7 0.0 2.7 3 0 0 3 3 3 1 Ferric reductase NAD binding domain DUF4330 PF14221.6 ETO30626.1 - 0.045 14.0 0.1 0.08 13.2 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4330) Rad60-SLD PF11976.8 ETO30626.1 - 0.052 13.4 1.5 0.094 12.6 0.4 2.0 2 0 0 2 2 2 0 Ubiquitin-2 like Rad60 SUMO-like TssO PF17561.2 ETO30626.1 - 0.14 12.3 0.1 0.14 12.3 0.1 2.0 3 0 0 3 3 3 0 Type VI secretion system, TssO ODV-E18 PF10717.9 ETO30626.1 - 0.16 11.9 0.0 0.28 11.1 0.0 1.3 1 0 0 1 1 1 0 Occlusion-derived virus envelope protein ODV-E18 RhoGEF PF00621.20 ETO30627.1 - 6.4e-14 52.6 2.0 6.4e-14 52.6 2.0 1.6 2 0 0 2 2 2 1 RhoGEF domain LIM PF00412.22 ETO30628.1 - 1.8e-07 31.3 12.3 3e-06 27.4 6.2 3.6 3 1 1 4 4 3 1 LIM domain bZIP_1 PF00170.21 ETO30628.1 - 0.0029 17.7 27.5 0.096 12.8 1.2 4.5 4 0 0 4 4 4 3 bZIP transcription factor DUF2935 PF11155.8 ETO30628.1 - 0.019 15.3 0.2 1.8 8.9 0.0 2.8 1 1 1 2 2 2 0 Domain of unknown function (DUF2935) ZapB PF06005.12 ETO30628.1 - 0.034 14.6 2.3 0.034 14.6 2.3 5.3 3 1 2 5 5 5 0 Cell division protein ZapB bZIP_2 PF07716.15 ETO30628.1 - 0.096 12.8 31.4 0.13 12.4 2.0 4.6 5 0 0 5 5 5 0 Basic region leucine zipper HALZ PF02183.18 ETO30628.1 - 0.19 12.0 28.5 0.56 10.5 1.8 5.1 3 2 1 4 4 4 0 Homeobox associated leucine zipper PikAIV_N PF18605.1 ETO30628.1 - 0.28 10.8 16.1 7 6.3 0.1 4.6 4 0 0 4 4 4 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain CCDC92 PF14916.6 ETO30628.1 - 0.32 10.8 10.0 0.16 11.7 0.7 3.4 2 1 1 3 3 3 0 Coiled-coil domain of unknown function DUF484 PF04340.12 ETO30628.1 - 0.32 10.7 4.2 0.8 9.4 4.2 1.6 1 0 0 1 1 1 0 Protein of unknown function, DUF484 PRKG1_interact PF15898.5 ETO30628.1 - 0.34 11.9 34.2 0.17 12.8 0.9 4.7 4 0 0 4 4 4 0 cGMP-dependent protein kinase interacting domain DivIC PF04977.15 ETO30628.1 - 0.41 10.5 31.5 0.17 11.7 3.3 4.6 5 1 0 5 5 5 0 Septum formation initiator ATPase PF06745.13 ETO30628.1 - 0.61 9.4 6.6 0.52 9.6 4.4 1.9 1 1 1 2 2 2 0 KaiC YabA PF06156.13 ETO30628.1 - 1.3 9.7 37.6 0.51 11.0 2.0 4.9 3 1 2 5 5 5 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 ETO30628.1 - 1.3 9.1 38.3 0.075 13.1 20.4 3.1 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein NYD-SP28_assoc PF14775.6 ETO30628.1 - 1.9 8.6 22.0 0.085 13.0 2.0 4.6 3 1 1 4 4 4 0 Sperm tail C-terminal domain JIP_LZII PF16471.5 ETO30628.1 - 2.3 8.5 28.6 0.17 12.1 2.5 4.8 3 2 1 4 4 4 0 JNK-interacting protein leucine zipper II Shugoshin_N PF07558.11 ETO30628.1 - 5.8 6.9 16.5 6.5 6.7 0.5 5.1 5 1 0 5 5 5 0 Shugoshin N-terminal coiled-coil region DUF2039 PF10217.9 ETO30628.1 - 6.8 7.1 18.1 8.1 6.9 0.1 3.2 3 0 0 3 3 3 0 Uncharacterized conserved protein (DUF2039) Phage_GPO PF05929.11 ETO30628.1 - 9.4 5.8 22.8 0.17 11.4 9.6 3.1 3 1 0 3 3 3 0 Phage capsid scaffolding protein (GPO) serine peptidase Rootletin PF15035.6 ETO30628.1 - 9.9 6.1 30.8 0.098 12.7 0.7 3.5 3 1 0 3 3 3 0 Ciliary rootlet component, centrosome cohesion RhoGEF PF00621.20 ETO30629.1 - 2.3e-14 54.0 2.1 1.6e-13 51.3 0.6 2.1 2 0 0 2 2 2 1 RhoGEF domain FYVE PF01363.21 ETO30629.1 - 5.8e-05 23.2 0.8 0.00011 22.3 0.8 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH PF00169.29 ETO30629.1 - 0.0013 19.2 0.0 0.0024 18.4 0.0 1.4 1 0 0 1 1 1 1 PH domain GAT PF03127.14 ETO30630.1 - 0.00058 20.1 0.4 0.0019 18.4 0.4 1.9 1 0 0 1 1 1 1 GAT domain Mucin PF01456.17 ETO30630.1 - 0.0097 15.9 22.9 0.1 12.6 6.5 2.2 2 0 0 2 2 2 2 Mucin-like glycoprotein Macoilin PF09726.9 ETO30630.1 - 1.1 7.8 11.8 1.7 7.1 11.8 1.2 1 0 0 1 1 1 0 Macoilin family Ribosomal_L23 PF00276.20 ETO30631.1 - 8.4e-17 61.3 2.8 1.6e-15 57.2 2.8 2.0 1 1 0 1 1 1 1 Ribosomal protein L23 TusA PF01206.17 ETO30631.1 - 0.0037 17.1 0.2 0.006 16.4 0.2 1.4 1 1 0 1 1 1 1 Sulfurtransferase TusA Linker_histone PF00538.19 ETO30631.1 - 0.019 15.3 0.2 0.038 14.3 0.2 1.6 1 1 0 1 1 1 0 linker histone H1 and H5 family Helicase_C PF00271.31 ETO30632.1 - 1.6e-23 83.1 0.0 3.1e-23 82.2 0.0 1.5 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO30632.1 - 2.5e-06 27.4 0.3 5.4e-06 26.3 0.1 1.6 2 0 0 2 2 2 1 DEAD/DEAH box helicase DEAD PF00270.29 ETO30633.1 - 1.4e-05 24.9 0.1 0.00017 21.4 0.1 2.0 1 1 0 1 1 1 1 DEAD/DEAH box helicase ABC_tran PF00005.27 ETO30634.1 - 1.5e-07 32.0 0.1 0.0044 17.5 0.0 3.5 3 1 0 3 3 3 2 ABC transporter SMC_N PF02463.19 ETO30634.1 - 0.0099 15.3 0.0 0.02 14.3 0.0 1.5 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain zf-CCCH_7 PF18586.1 ETO30635.1 - 0.065 13.6 2.2 2 8.8 0.2 2.5 2 1 0 2 2 2 0 Chromatin remodeling factor Mit1 C-terminal Zn finger 1 Tli4_C PF18426.1 ETO30635.1 - 0.29 11.4 0.6 23 5.2 0.0 2.6 3 0 0 3 3 3 0 Tle cognate immunity protein 4 C-terminal domain Mucin PF01456.17 ETO30637.1 - 0.0045 17.0 1.4 0.0045 17.0 1.4 2.3 2 0 0 2 2 2 1 Mucin-like glycoprotein NPR3 PF03666.13 ETO30637.1 - 1.3 7.7 10.5 2.2 7.0 10.5 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SURF2 PF05477.11 ETO30637.1 - 2.3 7.8 9.3 4.8 6.8 9.3 1.5 1 0 0 1 1 1 0 Surfeit locus protein 2 (SURF2) Retinal PF15449.6 ETO30638.1 - 0.069 10.9 7.6 0.079 10.7 7.6 1.0 1 0 0 1 1 1 0 Retinal protein Ham1p_like PF01725.16 ETO30639.1 - 9.8e-46 156.0 0.0 1.1e-45 155.8 0.0 1.0 1 0 0 1 1 1 1 Ham1 family AA_permease PF00324.21 ETO30640.1 - 1.4e-52 178.9 31.6 6.9e-30 104.1 17.8 2.2 1 1 1 2 2 2 2 Amino acid permease AA_permease_2 PF13520.6 ETO30640.1 - 6.2e-14 51.7 34.0 1.1e-11 44.2 18.2 2.4 1 1 1 2 2 2 2 Amino acid permease SLC12 PF03522.15 ETO30640.1 - 6.2e-10 38.7 32.4 4.6e-07 29.2 32.4 3.0 1 1 0 1 1 1 1 Solute carrier family 12 Zip PF02535.22 ETO30640.1 - 5e-07 29.2 2.4 1.5e-06 27.7 2.4 1.8 1 0 0 1 1 1 1 ZIP Zinc transporter SARAF PF06682.12 ETO30640.1 - 0.00077 19.2 0.6 0.0016 18.2 0.6 1.4 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis SpoIIIAH PF12685.7 ETO30640.1 - 0.0036 17.1 7.6 0.0036 17.1 7.6 2.3 3 0 0 3 3 3 1 SpoIIIAH-like protein Connexin PF00029.19 ETO30640.1 - 0.0052 16.6 3.2 0.0052 16.6 3.2 2.3 2 0 0 2 2 1 1 Connexin SID-1_RNA_chan PF13965.6 ETO30640.1 - 0.42 9.0 12.0 0.15 10.5 5.3 2.7 2 1 0 2 2 2 0 dsRNA-gated channel SID-1 CPSF100_C PF13299.6 ETO30640.1 - 1 9.5 9.2 1.1 9.4 6.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal ETRAMP PF09716.10 ETO30640.1 - 1.1 9.4 16.7 0.65 10.1 12.4 3.0 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) RNA_pol_Rpc4 PF05132.14 ETO30640.1 - 2.8 8.4 9.7 0.99 9.8 6.1 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 OAD_gamma PF04277.13 ETO30640.1 - 7.5 7.2 7.9 2.8e+02 2.2 7.9 3.0 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Neur_chan_memb PF02932.16 ETO30640.1 - 9.4 6.2 8.7 30 4.5 5.5 2.7 2 1 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region PAF PF15715.5 ETO30640.1 - 9.4 6.8 19.7 7.6 7.1 15.6 2.3 2 0 0 2 2 2 0 PCNA-associated factor histone like domain Pkinase PF00069.25 ETO30642.1 - 1.2e-50 172.3 0.6 1.3e-48 165.7 0.0 2.7 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30642.1 - 3.9e-21 75.5 0.0 1.2e-09 37.8 0.0 2.7 1 1 1 2 2 2 2 Protein tyrosine kinase FeoB_N PF02421.18 ETO30642.1 - 0.022 14.3 0.1 0.044 13.3 0.1 1.5 1 0 0 1 1 1 0 Ferrous iron transport protein B DUF87 PF01935.17 ETO30643.1 - 0.011 15.9 0.7 0.013 15.6 0.7 1.0 1 0 0 1 1 1 0 Helicase HerA, central domain PSII_Pbs27 PF13326.6 ETO30643.1 - 0.04 14.3 0.0 0.044 14.1 0.0 1.2 1 0 0 1 1 1 0 Photosystem II Pbs27 Suppressor_APC PF11414.8 ETO30643.1 - 0.15 12.2 0.1 0.2 11.7 0.1 1.2 1 0 0 1 1 1 0 Adenomatous polyposis coli tumour suppressor protein FRB_dom PF08771.11 ETO30645.1 - 0.018 15.5 0.2 0.038 14.4 0.2 1.6 1 0 0 1 1 1 0 FKBP12-rapamycin binding domain Dicty_REP PF05086.12 ETO30646.1 - 0.00069 17.8 25.2 0.00069 17.8 25.2 3.4 2 1 1 3 3 3 1 Dictyostelium (Slime Mold) REP protein Pkinase_fungal PF17667.1 ETO30646.1 - 0.12 11.2 0.0 0.12 11.2 0.0 4.9 3 1 0 3 3 3 0 Fungal protein kinase Zip PF02535.22 ETO30647.1 - 5.3 6.2 40.6 0.57 9.4 15.7 2.5 2 1 0 2 2 2 0 ZIP Zinc transporter WD40 PF00400.32 ETO30649.1 - 2e-28 98.0 12.7 2.6e-10 40.7 0.5 4.6 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30649.1 - 1.1e-09 38.4 3.1 0.004 17.4 0.1 4.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO30649.1 - 3.1e-06 27.3 5.6 0.17 12.2 0.0 4.7 5 0 0 5 5 5 3 Kelch motif WD40_like PF17005.5 ETO30649.1 - 1.6e-05 24.4 8.6 0.00024 20.6 0.3 3.9 2 2 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO30649.1 - 4.2e-05 22.7 0.2 0.1 11.6 0.0 3.6 2 1 2 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_4 PF13418.6 ETO30649.1 - 9.6e-05 22.3 4.8 0.0051 16.8 0.1 4.2 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO30649.1 - 0.0012 19.1 0.4 0.096 13.0 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO30649.1 - 0.0085 15.7 4.2 5 6.8 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO30649.1 - 0.026 14.5 4.2 0.53 10.3 0.8 3.8 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO30650.1 - 7.8e-15 55.0 0.5 1e-05 26.1 0.0 3.1 3 0 0 3 3 3 3 WD domain, G-beta repeat WD40_like PF17005.5 ETO30650.1 - 0.0012 18.2 1.2 0.0018 17.6 1.2 1.3 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO30650.1 - 0.0059 15.3 1.0 0.017 13.8 0.1 1.9 1 1 1 2 2 2 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO30650.1 - 0.01 16.1 0.1 0.54 10.6 0.1 2.5 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Mito_carr PF00153.27 ETO30651.1 - 0.00018 21.3 2.8 0.0024 17.7 0.5 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein SSV1_ORF_D-335 PF07935.11 ETO30652.1 - 0.11 12.9 0.8 0.22 11.8 0.8 1.5 1 0 0 1 1 1 0 ORF D-335-like protein S1FA PF04689.13 ETO30652.1 - 0.39 10.9 0.0 0.39 10.9 0.0 3.5 3 1 1 4 4 4 0 DNA binding protein S1FA U79_P34 PF03064.16 ETO30653.1 - 0.075 12.4 8.9 0.086 12.2 8.9 1.2 1 0 0 1 1 1 0 HSV U79 / HCMV P34 Atg14 PF10186.9 ETO30653.1 - 0.13 11.4 8.7 0.14 11.2 8.7 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 MCU PF04678.13 ETO30653.1 - 0.16 12.1 3.9 0.24 11.5 3.9 1.4 1 0 0 1 1 1 0 Mitochondrial calcium uniporter Borrelia_P83 PF05262.11 ETO30653.1 - 0.22 10.0 10.8 0.23 9.9 10.8 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Rrn6 PF10214.9 ETO30653.1 - 0.26 9.7 7.8 0.29 9.6 7.8 1.0 1 0 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor DUF1168 PF06658.12 ETO30653.1 - 0.47 10.3 22.9 0.8 9.5 22.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1168) Vfa1 PF08432.10 ETO30653.1 - 0.49 10.7 13.2 0.7 10.2 13.2 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Exonuc_VII_L PF02601.15 ETO30653.1 - 1.2 8.7 6.5 1.2 8.6 6.5 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1682 PF07946.14 ETO30653.1 - 1.6 7.8 16.4 2 7.5 16.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) DDHD PF02862.17 ETO30653.1 - 1.8 8.7 5.2 2.1 8.5 5.2 1.2 1 0 0 1 1 1 0 DDHD domain Connexin PF00029.19 ETO30653.1 - 2.1 8.0 5.5 2.2 8.0 5.5 1.3 1 0 0 1 1 1 0 Connexin COG2 PF06148.11 ETO30653.1 - 7.6 6.6 10.6 14 5.7 10.6 1.5 1 1 0 1 1 1 0 COG (conserved oligomeric Golgi) complex component, COG2 ETRAMP PF09716.10 ETO30655.1 - 0.0021 18.0 0.0 0.0021 18.0 0.0 3.3 1 1 1 2 2 2 1 Malarial early transcribed membrane protein (ETRAMP) Mucin PF01456.17 ETO30655.1 - 0.034 14.1 11.6 0.13 12.2 11.6 2.0 1 1 0 1 1 1 0 Mucin-like glycoprotein Herpes_glycop PF01528.16 ETO30655.1 - 0.14 11.0 0.2 0.26 10.1 0.2 1.4 1 0 0 1 1 1 0 Herpesvirus glycoprotein M DUF3169 PF11368.8 ETO30655.1 - 3.8 6.9 5.3 22 4.4 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3169) DHHW PF14286.6 ETO30656.1 - 0.029 13.7 0.1 0.042 13.2 0.1 1.3 1 0 0 1 1 1 0 DHHW protein Trypan_glycop PF00913.19 ETO30656.1 - 0.077 12.3 0.2 0.1 11.8 0.2 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) AAA PF00004.29 ETO30657.1 - 2.5e-09 37.6 0.1 1.5e-05 25.5 0.0 3.5 3 1 0 3 3 3 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO30657.1 - 1.9e-07 30.8 1.9 0.0049 16.4 0.1 2.8 2 1 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO30657.1 - 6.2e-07 29.5 0.0 0.0018 18.3 0.0 3.0 2 1 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO30657.1 - 4.3e-06 27.0 0.0 0.012 15.9 0.0 2.8 2 0 0 2 2 2 2 AAA domain Rad17 PF03215.15 ETO30657.1 - 4.6e-05 23.4 3.0 1.7 8.5 0.3 3.7 3 0 0 3 3 3 2 Rad17 P-loop domain AAA_8 PF12780.7 ETO30657.1 - 4.7e-05 22.8 0.4 0.00014 21.3 0.0 2.0 2 1 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_16 PF13191.6 ETO30657.1 - 0.00018 22.0 0.9 0.1 13.0 0.0 3.7 2 1 2 4 4 4 1 AAA ATPase domain DUF815 PF05673.13 ETO30657.1 - 0.00061 19.0 0.1 0.0028 16.9 0.0 2.2 3 0 0 3 3 3 1 Protein of unknown function (DUF815) MCM PF00493.23 ETO30657.1 - 0.0016 17.6 0.1 0.27 10.3 0.0 3.0 3 0 0 3 3 3 1 MCM P-loop domain AAA_14 PF13173.6 ETO30657.1 - 0.0021 18.1 2.8 0.015 15.3 0.0 3.1 2 1 1 3 3 3 1 AAA domain ADSL_C PF10397.9 ETO30657.1 - 0.0081 16.7 0.0 0.38 11.3 0.0 2.6 2 1 0 2 2 2 1 Adenylosuccinate lyase C-terminus PduV-EutP PF10662.9 ETO30657.1 - 0.009 15.8 1.4 0.12 12.1 0.1 2.5 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation RsgA_GTPase PF03193.16 ETO30657.1 - 0.012 15.5 0.0 0.041 13.8 0.0 1.9 2 0 0 2 2 1 0 RsgA GTPase ABC_tran PF00005.27 ETO30657.1 - 0.014 16.0 4.7 0.016 15.7 0.0 3.1 4 0 0 4 4 4 0 ABC transporter TsaE PF02367.17 ETO30657.1 - 0.014 15.4 0.0 0.17 11.9 0.0 2.3 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_19 PF13245.6 ETO30657.1 - 0.018 15.3 0.2 10 6.4 0.1 2.7 2 0 0 2 2 2 0 AAA domain IstB_IS21 PF01695.17 ETO30657.1 - 0.019 14.7 0.0 0.21 11.3 0.0 2.5 2 0 0 2 2 2 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 ETO30657.1 - 0.024 14.3 0.1 0.38 10.5 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Mg_chelatase PF01078.21 ETO30657.1 - 0.038 13.4 0.4 11 5.4 0.1 2.9 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI RNA_helicase PF00910.22 ETO30657.1 - 0.054 13.9 0.0 2.7 8.4 0.0 2.9 2 0 0 2 2 2 0 RNA helicase Sigma54_activ_2 PF14532.6 ETO30657.1 - 0.1 12.7 0.2 3.7 7.7 0.0 3.1 3 1 0 3 3 3 0 Sigma-54 interaction domain AAA_25 PF13481.6 ETO30657.1 - 0.12 11.9 0.1 7.2 6.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain NACHT PF05729.12 ETO30657.1 - 0.29 11.0 3.5 1.2 9.0 0.1 3.3 3 1 0 4 4 4 0 NACHT domain Peptidase_S49_N PF08496.10 ETO30657.1 - 0.29 11.2 3.7 0.74 9.9 3.7 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal DUF4710 PF15828.5 ETO30657.1 - 0.48 10.6 4.7 1.5 9.0 4.7 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4710) Arm-DNA-bind_2 PF12167.8 ETO30657.1 - 0.99 9.4 3.4 0.8 9.7 0.5 2.3 2 1 0 2 2 2 0 Arm DNA-binding domain MAS20 PF02064.15 ETO30657.1 - 1.9 8.6 6.6 1.4 9.1 2.5 2.3 2 0 0 2 2 2 0 MAS20 protein import receptor TPP_enzyme_C PF02775.21 ETO30658.1 - 8.5e-19 67.8 0.1 1.8e-18 66.8 0.1 1.6 1 1 0 1 1 1 1 Thiamine pyrophosphate enzyme, C-terminal TPP binding domain eIF3_p135 PF12807.7 ETO30659.1 - 0.016 15.3 0.7 0.033 14.2 0.3 1.6 2 0 0 2 2 2 0 Translation initiation factor eIF3 subunit 135 Presenilin PF01080.17 ETO30659.1 - 0.22 10.3 0.5 0.23 10.2 0.5 1.2 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 ETO30659.1 - 0.79 9.8 4.6 0.56 10.2 1.9 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal DUF4834 PF16118.5 ETO30659.1 - 5 8.1 7.4 0.24 12.4 1.1 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Kelch_2 PF07646.15 ETO30660.1 - 0.013 15.5 9.5 5.9 7.0 0.1 5.3 5 1 0 5 5 5 0 Kelch motif DUF2921 PF11145.8 ETO30660.1 - 0.016 13.1 0.4 0.023 12.5 0.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2921) Kelch_6 PF13964.6 ETO30660.1 - 0.025 14.8 4.6 5.4 7.4 0.0 4.1 4 1 1 5 5 5 0 Kelch motif DUF2856 PF11043.8 ETO30661.1 - 0.032 14.4 0.0 1.7 8.8 0.0 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF2856) TK PF00265.18 ETO30662.1 - 0.088 12.7 0.2 0.32 10.8 0.0 2.0 2 0 0 2 2 2 0 Thymidine kinase CDC45 PF02724.14 ETO30663.1 - 0.16 10.3 6.7 0.18 10.1 6.7 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF5533 PF17685.1 ETO30663.1 - 0.19 12.1 2.2 0.25 11.7 2.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5533) CobU PF02283.16 ETO30663.1 - 0.46 10.0 3.5 0.45 10.1 0.1 2.0 1 1 1 2 2 2 0 Cobinamide kinase / cobinamide phosphate guanyltransferase SDA1 PF05285.12 ETO30664.1 - 0.0071 15.8 23.8 0.012 15.1 23.8 1.3 1 0 0 1 1 1 1 SDA1 AMMECR1 PF01871.17 ETO30664.1 - 0.038 13.6 0.0 0.067 12.8 0.0 1.4 1 0 0 1 1 1 0 AMMECR1 Cwf_Cwc_15 PF04889.12 ETO30664.1 - 0.083 12.6 23.9 0.13 12.0 23.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Neur_chan_memb PF02932.16 ETO30664.1 - 3.8 7.5 6.0 5 7.1 6.0 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Menin PF05053.13 ETO30664.1 - 6.6 5.0 13.1 8.1 4.7 13.1 1.1 1 0 0 1 1 1 0 Menin WD40 PF00400.32 ETO30665.1 - 8.9e-68 222.6 9.4 9.4e-11 42.1 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30665.1 - 5.2e-24 84.4 3.9 0.00023 21.4 0.1 6.8 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30665.1 - 7.6e-15 54.7 0.9 0.0041 16.1 0.0 6.4 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO30665.1 - 1.1e-10 41.4 0.3 0.029 13.7 0.0 4.0 2 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO30665.1 - 3.6e-10 39.1 5.2 0.15 10.7 0.1 5.0 2 2 3 5 5 5 5 Nucleoporin Nup120/160 PD40 PF07676.12 ETO30665.1 - 0.00058 19.7 0.7 13 5.8 0.0 5.7 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO30665.1 - 0.004 16.0 4.1 3 6.5 0.1 4.1 1 1 1 3 3 3 2 Nup133 N terminal like Nbas_N PF15492.6 ETO30665.1 - 0.0062 15.9 0.5 16 4.7 0.0 3.6 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Drf_FH3 PF06367.16 ETO30666.1 - 0.0016 18.1 1.5 0.0022 17.6 0.3 1.7 2 0 0 2 2 2 1 Diaphanous FH3 Domain DUF3863 PF12979.7 ETO30666.1 - 0.038 12.8 0.0 0.074 11.9 0.0 1.4 2 0 0 2 2 2 0 Domain of Unknown Function with PDB structure (DUF3863) Sec7 PF01369.20 ETO30666.1 - 0.055 13.1 0.3 0.092 12.4 0.3 1.6 1 1 0 1 1 1 0 Sec7 domain UBA_e1_thiolCys PF10585.9 ETO30666.1 - 0.13 12.1 0.2 0.28 11.1 0.0 1.6 2 1 0 2 2 2 0 Ubiquitin-activating enzyme active site Dicty_REP PF05086.12 ETO30669.1 - 0.07 11.1 10.5 0.12 10.4 10.5 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4611 PF15387.6 ETO30669.1 - 0.52 10.6 11.1 3.6 7.9 5.6 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ETO30669.1 - 2 8.1 8.2 7.5 6.2 3.0 2.7 2 0 0 2 2 2 0 FAM176 family DUF4407 PF14362.6 ETO30669.1 - 3.8 6.8 7.4 5.8 6.2 7.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF968 PF06147.11 ETO30670.1 - 0.1 12.8 0.7 0.32 11.2 0.2 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF968) DIE2_ALG10 PF04922.12 ETO30671.1 - 0.21 10.8 1.3 0.34 10.1 1.3 1.3 1 0 0 1 1 1 0 DIE2/ALG10 family 60KD_IMP PF02096.20 ETO30672.1 - 5.2e-09 36.2 1.3 7.4e-09 35.7 0.1 1.7 2 0 0 2 2 2 1 60Kd inner membrane protein Holin_BlyA PF05102.12 ETO30675.1 - 0.72 9.8 5.4 0.16 11.9 0.5 2.3 2 0 0 2 2 2 0 holin, BlyA family Staphostatin_A PF09022.10 ETO30676.1 - 0.21 11.5 2.2 10 6.1 0.6 2.1 1 1 1 2 2 2 0 Staphostatin A PA26 PF04636.13 ETO30677.1 - 0.007 15.3 3.9 0.0075 15.2 3.9 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) Sod_Ni PF09055.11 ETO30677.1 - 0.078 13.5 1.9 0.12 13.0 1.9 1.3 1 0 0 1 1 1 0 Nickel-containing superoxide dismutase GET2 PF08690.10 ETO30677.1 - 5.4 6.6 11.9 6.2 6.4 11.9 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 Hid1 PF12722.7 ETO30677.1 - 6.7 4.7 9.4 7.1 4.6 9.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NLRC4_HD PF17889.1 ETO30678.1 - 0.035 14.4 0.5 0.13 12.6 0.1 1.9 1 1 1 2 2 2 0 NLRC4 helical domain PhnI PF05861.12 ETO30681.1 - 0.0078 15.1 0.1 0.0082 15.0 0.1 1.0 1 0 0 1 1 1 1 Bacterial phosphonate metabolism protein (PhnI) DUF2443 PF10398.9 ETO30682.1 - 0.067 13.2 0.2 0.23 11.5 0.2 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2443) ABC_tran PF00005.27 ETO30683.1 - 0.00011 22.7 0.0 0.0016 19.0 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AAA_5 PF07728.14 ETO30683.1 - 0.00016 21.7 0.0 0.00035 20.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO30683.1 - 0.0015 18.1 0.1 0.0048 16.4 0.1 1.9 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO30683.1 - 0.0021 18.5 0.0 0.0052 17.2 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ETO30683.1 - 0.0086 16.0 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ETO30683.1 - 0.02 15.1 0.0 0.057 13.7 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO30683.1 - 0.083 13.3 0.0 0.21 12.0 0.0 1.6 1 1 0 1 1 1 0 AAA ATPase domain SecA_DEAD PF07517.14 ETO30683.1 - 0.12 11.7 0.1 0.3 10.3 0.0 1.8 1 1 1 2 2 2 0 SecA DEAD-like domain Kinesin PF00225.23 ETO30684.1 - 8.2e-60 202.5 1.0 8.2e-60 202.5 1.0 3.0 3 2 1 4 4 4 1 Kinesin motor domain adh_short_C2 PF13561.6 ETO30686.1 - 8.7e-33 113.8 4.7 9.3e-19 67.9 0.2 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase adh_short PF00106.25 ETO30686.1 - 7.7e-31 107.1 2.3 6.1e-22 78.0 0.1 2.2 2 0 0 2 2 2 2 short chain dehydrogenase KR PF08659.10 ETO30686.1 - 4.2e-05 23.5 1.4 0.00011 22.2 0.3 2.1 2 0 0 2 2 2 1 KR domain PUF PF00806.19 ETO30687.1 - 5.8e-44 145.4 19.0 2.6e-07 30.0 0.4 8.7 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat Cys_box PF17869.1 ETO30687.1 - 5.2 7.3 7.9 12 6.1 1.0 3.7 3 0 0 3 3 3 0 Anosmin cysteine rich domain BST2 PF16716.5 ETO30688.1 - 0.0019 18.8 0.4 0.0034 17.9 0.4 1.4 1 0 0 1 1 1 1 Bone marrow stromal antigen 2 CdvA PF18822.1 ETO30688.1 - 0.003 17.4 1.3 0.0054 16.5 1.3 1.3 1 0 0 1 1 1 1 CdvA-like coiled-coil domain Lebercilin PF15619.6 ETO30688.1 - 0.0065 16.2 0.7 0.0091 15.7 0.7 1.2 1 0 0 1 1 1 1 Ciliary protein causing Leber congenital amaurosis disease ZapB PF06005.12 ETO30688.1 - 0.012 16.0 3.5 0.026 15.0 3.5 1.5 1 0 0 1 1 1 0 Cell division protein ZapB TPR_MLP1_2 PF07926.12 ETO30688.1 - 0.014 15.4 0.9 0.025 14.7 0.9 1.4 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 ETO30688.1 - 0.033 14.2 1.6 1.7 8.8 1.1 2.8 2 1 1 3 3 3 0 TolA binding protein trimerisation DUF1319 PF07028.11 ETO30688.1 - 0.14 12.4 1.5 0.41 10.9 1.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) DivIC PF04977.15 ETO30688.1 - 0.18 11.6 2.7 0.47 10.3 1.3 2.2 2 0 0 2 2 2 0 Septum formation initiator Noggin PF05806.12 ETO30688.1 - 0.2 11.5 0.6 0.27 11.1 0.6 1.2 1 0 0 1 1 1 0 Noggin NIF PF03031.18 ETO30689.1 - 1.6e-09 37.7 0.2 1.9e-09 37.5 0.2 1.2 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Sec7 PF01369.20 ETO30690.1 - 2.5e-28 99.0 0.0 2.5e-28 99.0 0.0 2.6 2 0 0 2 2 2 1 Sec7 domain DUF2464 PF10240.9 ETO30690.1 - 0.00017 21.2 8.3 0.00017 21.2 8.3 5.1 5 1 0 5 5 5 1 Multivesicular body subunit 12 CTK3 PF12243.8 ETO30690.1 - 0.02 14.9 3.5 0.28 11.2 0.1 3.6 3 0 0 3 3 3 0 CTD kinase subunit gamma CTK3 Sec7_N PF12783.7 ETO30690.1 - 0.11 12.4 0.0 0.11 12.4 0.0 3.6 3 0 0 3 3 3 0 Guanine nucleotide exchange factor in Golgi transport N-terminal FYVE_2 PF02318.16 ETO30691.1 - 1.8e-05 24.9 7.4 2.8e-05 24.3 7.4 1.4 1 0 0 1 1 1 1 FYVE-type zinc finger ZZ PF00569.17 ETO30691.1 - 1 9.2 15.4 0.48 10.3 10.5 2.7 2 0 0 2 2 2 0 Zinc finger, ZZ type Tropomyosin_1 PF12718.7 ETO30692.1 - 4.6e-05 23.6 22.5 4.6e-05 23.6 22.5 2.3 2 0 0 2 2 2 1 Tropomyosin like ATG16 PF08614.11 ETO30692.1 - 0.00055 20.2 24.8 0.083 13.1 15.3 2.2 1 1 1 2 2 2 2 Autophagy protein 16 (ATG16) AAA_13 PF13166.6 ETO30692.1 - 0.00071 18.4 6.0 0.00071 18.4 6.0 1.7 2 0 0 2 2 2 1 AAA domain PHBC_N PF12551.8 ETO30692.1 - 0.0019 18.0 0.0 0.003 17.3 0.0 1.3 1 0 0 1 1 1 1 Poly-beta-hydroxybutyrate polymerase N terminal HOOK PF05622.12 ETO30692.1 - 0.0023 16.2 24.1 0.0023 16.2 24.1 1.9 2 0 0 2 2 2 1 HOOK protein TPR_MLP1_2 PF07926.12 ETO30692.1 - 0.0079 16.3 10.2 0.0079 16.3 10.2 3.2 2 1 1 3 3 3 2 TPR/MLP1/MLP2-like protein DegS PF05384.11 ETO30692.1 - 0.014 14.9 4.3 0.014 14.9 4.3 3.1 2 1 1 3 3 3 0 Sensor protein DegS Laminin_II PF06009.12 ETO30692.1 - 0.018 15.1 19.2 0.082 12.9 2.4 2.7 2 1 1 3 3 3 0 Laminin Domain II Csm1_N PF18504.1 ETO30692.1 - 0.019 15.3 8.3 0.019 15.3 8.3 4.1 2 2 3 5 5 4 0 Csm1 N-terminal domain KELK PF15796.5 ETO30692.1 - 0.029 14.8 10.4 0.029 14.8 10.4 3.2 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PMEI PF04043.15 ETO30692.1 - 0.034 14.5 9.9 0.16 12.3 9.5 2.2 1 1 0 1 1 1 0 Plant invertase/pectin methylesterase inhibitor DUF4795 PF16043.5 ETO30692.1 - 0.13 11.8 20.4 0.012 15.2 14.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4795) HetR_C PF18460.1 ETO30692.1 - 0.16 11.9 2.8 0.25 11.3 0.4 2.4 1 1 1 2 2 2 0 Heterocyst differentiation regulator C-terminal Hood domain UCR_hinge PF02320.16 ETO30692.1 - 0.17 12.1 18.9 0.32 11.2 6.3 3.6 2 1 2 4 4 4 0 Ubiquinol-cytochrome C reductase hinge protein DUF3584 PF12128.8 ETO30692.1 - 0.45 8.0 26.0 0.019 12.6 18.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3584) Fez1 PF06818.15 ETO30692.1 - 0.76 10.2 27.5 0.11 12.9 20.8 2.0 2 0 0 2 2 2 0 Fez1 Spc7 PF08317.11 ETO30692.1 - 1.7 7.5 33.2 0.45 9.4 25.4 2.7 2 1 0 2 2 2 0 Spc7 kinetochore protein IFT57 PF10498.9 ETO30692.1 - 1.7 7.5 28.3 0.13 11.2 9.2 2.7 2 1 1 3 3 3 0 Intra-flagellar transport protein 57 Terminase_4 PF05119.12 ETO30692.1 - 1.7 9.1 7.8 3.4 8.2 3.5 2.9 2 1 0 2 2 2 0 Phage terminase, small subunit EzrA PF06160.12 ETO30692.1 - 2.4 6.2 24.9 0.1 10.7 17.1 2.3 2 1 0 2 2 2 0 Septation ring formation regulator, EzrA Adaptin_binding PF10199.9 ETO30692.1 - 3.4 8.3 11.6 16 6.1 0.8 2.3 1 1 1 2 2 2 0 Alpha and gamma adaptin binding protein p34 DUF4162 PF13732.6 ETO30692.1 - 3.4 8.4 6.8 1.2 9.9 1.9 2.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4162) DUF3288 PF11691.8 ETO30692.1 - 3.4 7.8 9.7 0.53 10.4 2.6 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3288) DUF3450 PF11932.8 ETO30692.1 - 4.9 6.4 28.2 0.057 12.7 6.8 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF3450) DUF948 PF06103.11 ETO30692.1 - 6.8 7.0 9.6 56 4.1 0.1 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) SlyX PF04102.12 ETO30692.1 - 7.2 7.3 24.9 8.1 7.1 0.0 5.0 2 1 3 5 5 5 0 SlyX TMPIT PF07851.13 ETO30692.1 - 7.6 5.7 27.4 0.056 12.7 6.3 2.9 2 1 1 3 3 3 0 TMPIT-like protein UPF0242 PF06785.11 ETO30692.1 - 7.7 6.6 35.4 5.7 7.0 24.2 2.9 2 1 1 3 3 3 0 Uncharacterised protein family (UPF0242) N-terminus Uds1 PF15456.6 ETO30692.1 - 8 6.6 25.2 0.062 13.5 10.4 3.0 2 1 1 3 3 3 0 Up-regulated During Septation DSPc PF00782.20 ETO30693.1 - 4.6e-05 23.3 0.2 4.6e-05 23.3 0.2 2.1 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain RLL PF10036.9 ETO30693.1 - 0.28 11.0 7.7 0.42 10.4 7.7 1.3 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein WD40 PF00400.32 ETO30695.1 - 9.4e-61 200.3 15.3 1.4e-09 38.4 0.1 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30695.1 - 1.7e-20 73.1 1.5 0.00013 22.2 0.0 6.6 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30695.1 - 8.2e-10 38.2 1.2 0.96 8.3 0.0 6.1 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO30695.1 - 5.5e-08 32.5 3.5 0.072 12.4 0.0 4.3 3 2 2 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO30695.1 - 0.00011 21.1 1.0 5.5 5.5 0.0 4.5 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO30695.1 - 0.0031 16.3 3.6 0.16 10.7 2.0 2.5 1 1 1 2 2 2 2 Nup133 N terminal like PD40 PF07676.12 ETO30695.1 - 0.01 15.7 12.3 4.7 7.3 0.3 5.6 6 1 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO30695.1 - 0.011 15.8 0.6 17 5.5 0.0 3.9 1 1 3 4 4 4 0 Family of unknown function (DUF5570) PQQ PF01011.21 ETO30695.1 - 0.02 14.8 0.0 7 6.8 0.0 3.8 3 0 0 3 3 3 0 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETO30695.1 - 0.054 12.0 0.8 3 6.3 0.2 2.6 1 1 1 2 2 2 0 Cytochrome D1 heme domain STAS PF01740.21 ETO30696.1 - 3.3e-23 81.5 0.1 5.8e-23 80.8 0.1 1.3 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO30696.1 - 2.7e-19 69.2 0.1 4.4e-19 68.5 0.1 1.3 1 0 0 1 1 1 1 Sulfate permease family MFS_MOT1 PF16983.5 ETO30696.1 - 0.012 16.0 2.2 0.012 16.0 2.2 1.8 2 0 0 2 2 2 0 Molybdate transporter of MFS superfamily Sulfate_transp PF00916.20 ETO30697.1 - 1.8e-20 73.1 3.3 2.1e-20 72.8 3.3 1.0 1 0 0 1 1 1 1 Sulfate permease family Scm3 PF10384.9 ETO30700.1 - 0.17 11.7 0.9 0.44 10.3 0.5 1.8 2 0 0 2 2 2 0 Centromere protein Scm3 HhH-GPD PF00730.25 ETO30701.1 - 0.042 14.3 0.2 0.06 13.8 0.2 1.2 1 0 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein DUF2263 PF10021.9 ETO30702.1 - 4.7e-25 88.7 0.5 3.2e-24 86.0 0.5 2.3 1 1 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2263) PARG_cat PF05028.14 ETO30702.1 - 0.013 14.8 0.8 0.075 12.3 0.0 2.2 2 0 0 2 2 2 0 Poly (ADP-ribose) glycohydrolase (PARG) WDCP PF15390.6 ETO30702.1 - 0.27 9.6 9.3 0.014 13.9 2.1 1.9 1 1 0 2 2 2 0 WD repeat and coiled-coil-containing protein family TPR_12 PF13424.6 ETO30703.1 - 3.7e-46 155.3 1.4 2.3e-17 63.0 0.1 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30703.1 - 1.1e-34 116.9 26.5 4.8e-08 32.5 0.5 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30703.1 - 5.2e-34 113.6 31.0 8.1e-06 25.7 0.1 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30703.1 - 2.4e-31 106.7 0.1 5.3e-06 26.1 0.0 6.7 6 1 1 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO30703.1 - 4.3e-30 101.5 0.8 3.4e-05 23.6 0.0 6.4 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO30703.1 - 6.8e-26 88.3 18.0 4e-05 23.4 0.1 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO30703.1 - 8.9e-13 47.7 11.2 0.034 14.5 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO30703.1 - 4.8e-10 39.4 4.9 1.3 9.8 0.0 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO30703.1 - 1.2e-08 35.3 0.8 0.017 15.6 0.0 4.5 3 1 2 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO30703.1 - 1.3e-07 31.2 22.2 0.05 13.3 0.1 7.0 6 3 2 8 8 8 3 TPR repeat TPR_14 PF13428.6 ETO30703.1 - 2.1e-06 28.1 0.0 15 6.7 0.0 5.2 5 0 0 5 5 5 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO30703.1 - 9.4e-06 25.5 12.9 0.43 10.4 0.1 5.2 2 1 1 3 3 3 3 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO30703.1 - 3.7e-05 23.8 11.0 0.069 13.4 0.4 4.7 1 1 3 4 4 4 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF2225 PF09986.9 ETO30703.1 - 4.7e-05 23.2 8.9 0.044 13.5 2.9 3.7 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_16 PF13432.6 ETO30703.1 - 0.00013 22.6 0.0 22 5.8 0.0 4.8 5 0 0 5 5 5 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO30703.1 - 0.00013 21.5 3.5 0.34 10.4 0.2 3.4 2 2 2 4 4 4 2 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETO30703.1 - 0.001 19.1 5.2 0.33 11.1 0.0 4.6 3 2 2 5 5 5 1 MIT (microtubule interacting and transport) domain mit_SMPDase PF14724.6 ETO30703.1 - 0.0029 15.7 1.1 0.15 10.0 0.1 2.6 1 1 2 3 3 3 2 Mitochondrial-associated sphingomyelin phosphodiesterase DUF627 PF04781.12 ETO30703.1 - 0.0048 16.9 2.9 0.089 12.8 0.5 3.1 2 1 1 3 3 3 1 Protein of unknown function (DUF627) PPR PF01535.20 ETO30703.1 - 0.0058 16.8 0.2 2.5 8.5 0.0 4.3 5 0 0 5 5 5 1 PPR repeat TPR_MalT PF17874.1 ETO30703.1 - 0.011 15.2 0.0 1.9 7.8 0.0 2.1 1 1 0 2 2 2 0 MalT-like TPR region SHNi-TPR PF10516.9 ETO30703.1 - 0.097 12.1 3.5 1.4 8.4 0.1 3.9 5 0 0 5 5 5 0 SHNi-TPR TPR_3 PF07720.12 ETO30703.1 - 0.17 11.9 22.4 1.3 9.1 0.1 6.1 6 0 0 6 6 6 0 Tetratricopeptide repeat WD40 PF00400.32 ETO30705.1 - 3.8e-34 116.2 24.2 8.7e-06 26.4 0.2 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30705.1 - 5.5e-10 39.4 2.4 0.0069 16.7 0.0 5.4 3 2 3 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO30705.1 - 7.9e-09 34.7 4.8 0.18 10.4 0.1 5.0 1 1 3 5 5 5 5 Nucleoporin Nup120/160 WD40 PF00400.32 ETO30706.1 - 1.1e-57 190.6 11.3 4.1e-10 40.1 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30706.1 - 4.4e-28 97.4 0.6 0.0027 18.0 0.0 7.0 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30706.1 - 1.3e-16 60.5 0.4 0.0037 16.3 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO30706.1 - 3.8e-15 56.3 0.1 0.00039 20.3 0.0 3.6 2 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO30706.1 - 2.2e-11 43.1 4.9 0.0021 16.8 0.0 4.9 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO30706.1 - 4.3e-09 36.1 0.1 0.00052 19.4 0.0 3.2 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO30706.1 - 3.4e-06 26.8 12.6 3.6 7.6 0.2 7.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO30706.1 - 1.1e-05 24.9 2.2 1.2 8.5 0.1 4.3 1 1 2 4 4 4 3 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO30706.1 - 3.5e-05 22.5 0.1 0.24 9.9 0.0 3.1 1 1 2 4 4 4 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO30706.1 - 0.00039 19.3 4.5 0.6 8.8 0.1 3.5 2 2 2 4 4 4 2 Nup133 N terminal like RicinB_lectin_2 PF14200.6 ETO30706.1 - 0.0012 19.5 0.9 0.0078 16.9 0.3 2.5 2 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain-like PQQ PF01011.21 ETO30706.1 - 0.0057 16.5 0.0 11 6.2 0.0 4.1 4 0 0 4 4 4 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO30706.1 - 0.0087 15.0 1.0 3.6 6.4 0.0 3.1 3 1 0 3 3 3 2 Partner and localizer of BRCA2 WD40 domain NHL PF01436.21 ETO30706.1 - 0.009 16.0 0.2 2.1 8.5 0.0 3.4 3 0 0 3 3 3 1 NHL repeat Ret2_MD PF18528.1 ETO30706.1 - 0.032 14.6 0.0 6.6 7.2 0.0 3.8 2 2 2 4 4 4 0 RNA editing 3' terminal uridylyl transferase 2 middle domain DUF2431 PF10354.9 ETO30706.1 - 0.036 14.4 0.0 4.2 7.6 0.0 3.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2431) DPPIV_N PF00930.21 ETO30706.1 - 0.038 12.8 0.2 12 4.5 0.0 3.6 2 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO30706.1 - 0.12 12.5 2.4 21 5.2 0.0 3.7 2 2 1 4 4 4 0 Family of unknown function (DUF5570) Utp8 PF10395.9 ETO30706.1 - 0.17 10.4 0.4 22 3.4 0.0 3.1 2 1 2 4 4 4 0 Utp8 family DUF5438 PF17506.2 ETO30707.1 - 0.33 11.3 3.0 0.23 11.8 0.4 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5438) FAD_binding_3 PF01494.19 ETO30708.1 - 0.028 13.6 0.0 0.038 13.2 0.0 1.0 1 0 0 1 1 1 0 FAD binding domain YqgF PF14639.6 ETO30709.1 - 0.068 13.0 1.0 0.083 12.7 0.2 1.6 1 1 1 2 2 2 0 Holliday-junction resolvase-like of SPT6 DBP10CT PF08147.12 ETO30709.1 - 6.3 7.1 10.5 0.62 10.4 4.8 2.2 1 1 1 2 2 2 0 DBP10CT (NUC160) domain UPF0061 PF02696.14 ETO30710.1 - 0.053 12.3 5.0 0.063 12.0 5.0 1.1 1 0 0 1 1 1 0 Uncharacterized ACR, YdiU/UPF0061 family bZIP_1 PF00170.21 ETO30710.1 - 0.091 12.9 2.9 0.23 11.6 2.9 1.7 1 0 0 1 1 1 0 bZIP transcription factor bZIP_2 PF07716.15 ETO30710.1 - 0.31 11.1 6.2 0.065 13.3 2.4 1.8 2 0 0 2 2 2 0 Basic region leucine zipper DcpS PF05652.12 ETO30712.1 - 0.018 15.9 0.9 0.026 15.4 0.2 1.6 1 1 1 2 2 2 0 Scavenger mRNA decapping enzyme (DcpS) N-terminal CdvA PF18822.1 ETO30713.1 - 0.0037 17.1 1.8 0.0057 16.5 1.8 1.2 1 0 0 1 1 1 1 CdvA-like coiled-coil domain Myosin_TH1 PF06017.13 ETO30714.1 - 8.8e-17 61.4 3.4 1.8e-16 60.3 2.1 1.7 1 1 1 2 2 2 1 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 ETO30714.1 - 0.003 17.3 0.0 0.0055 16.4 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase PH_3 PF14593.6 ETO30714.1 - 0.022 14.9 1.4 0.022 14.9 1.4 1.8 1 1 1 2 2 2 0 PH domain Ion_trans PF00520.31 ETO30716.1 - 1.4e-36 126.0 48.1 2.6e-22 79.3 18.7 2.3 2 0 0 2 2 2 2 Ion transport protein cNMP_binding PF00027.29 ETO30716.1 - 0.0063 16.6 0.0 0.018 15.1 0.0 1.7 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain CAC1F_C PF16885.5 ETO30716.1 - 0.044 13.5 1.9 0.08 12.6 1.9 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term GRP PF07172.11 ETO30716.1 - 0.1 13.3 0.4 0.1 13.3 0.4 3.0 3 0 0 3 3 3 0 Glycine rich protein family YL1 PF05764.13 ETO30716.1 - 7.8 6.5 18.5 0.058 13.5 6.8 2.2 2 0 0 2 2 2 0 YL1 nuclear protein Atg8 PF02991.16 ETO30718.1 - 7.7e-35 119.2 0.3 9e-35 119.0 0.3 1.1 1 0 0 1 1 1 1 Autophagy protein Atg8 ubiquitin like APG12 PF04110.13 ETO30718.1 - 0.019 15.4 0.1 0.025 15.0 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-like autophagy protein Apg12 DSPc PF00782.20 ETO30719.1 - 2.1e-08 34.1 0.0 4.6e-08 32.9 0.0 1.6 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Ribosomal_L14e PF01929.17 ETO30720.1 - 1.7e-16 60.4 1.9 5.5e-16 58.8 0.1 2.4 2 0 0 2 2 2 1 Ribosomal protein L14 N6_Mtase PF02384.16 ETO30720.1 - 0.097 11.9 0.1 0.15 11.3 0.1 1.2 1 0 0 1 1 1 0 N-6 DNA Methylase LRR_4 PF12799.7 ETO30721.1 - 0.00023 21.5 23.6 0.49 10.9 0.3 7.1 5 2 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO30721.1 - 0.00052 19.8 27.5 0.14 12.3 0.1 9.4 9 1 1 10 10 10 2 Leucine Rich repeat LRR_1 PF00560.33 ETO30721.1 - 1.5 9.7 18.4 49 5.0 0.2 7.6 7 0 0 7 7 7 0 Leucine Rich Repeat Dus PF01207.17 ETO30722.1 - 9.1e-24 84.1 0.0 1.5e-23 83.4 0.0 1.5 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) His_biosynth PF00977.21 ETO30722.1 - 0.0019 17.7 0.0 0.0034 16.9 0.0 1.4 1 0 0 1 1 1 1 Histidine biosynthesis protein Dus PF01207.17 ETO30723.1 - 4.4e-35 121.3 0.0 5.8e-35 120.9 0.0 1.0 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) MTABC_N PF16185.5 ETO30723.1 - 0.015 14.8 0.7 0.021 14.3 0.7 1.2 1 0 0 1 1 1 0 Mitochondrial ABC-transporter N-terminal five TM region GHMP_kinases_N PF00288.26 ETO30724.1 - 2.6e-12 46.8 1.2 1.7e-11 44.2 1.2 2.2 2 0 0 2 2 2 1 GHMP kinases N terminal domain GHMP_kinases_C PF08544.13 ETO30724.1 - 0.0001 22.6 0.0 0.00019 21.8 0.0 1.4 1 0 0 1 1 1 1 GHMP kinases C terminal Myosin_TH1 PF06017.13 ETO30726.1 - 8.9e-12 45.1 3.5 1.1e-11 44.8 2.9 1.5 1 1 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 ETO30726.1 - 0.0015 18.2 0.0 0.0027 17.4 0.0 1.5 1 0 0 1 1 1 1 Inositol phosphatase ParG PF09274.10 ETO30726.1 - 0.046 13.9 0.0 0.085 13.0 0.0 1.4 1 0 0 1 1 1 0 ParG TPR_12 PF13424.6 ETO30727.1 - 1.7e-25 89.1 0.6 8.6e-13 48.4 0.1 2.3 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30727.1 - 2e-12 46.3 9.2 9.1e-09 34.8 1.2 3.5 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30727.1 - 5.8e-12 44.8 6.1 1.2e-05 25.1 0.6 3.3 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO30727.1 - 6.4e-10 38.4 4.6 8.2e-06 25.5 0.3 3.8 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30727.1 - 1.1e-08 34.7 0.0 0.00061 19.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO30727.1 - 1.3e-08 34.2 0.1 0.0063 16.5 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO30727.1 - 5.9e-06 25.9 7.0 0.092 12.4 0.1 4.8 4 1 1 5 5 5 2 TPR repeat TPR_17 PF13431.6 ETO30727.1 - 0.00048 20.3 4.0 0.45 11.0 1.7 3.1 2 1 0 2 2 2 2 Tetratricopeptide repeat Pilin_PilX PF11530.8 ETO30727.1 - 0.014 15.3 0.0 0.025 14.5 0.0 1.4 1 0 0 1 1 1 0 Minor type IV pilin, PilX MinC_C PF03775.16 ETO30727.1 - 0.047 13.7 0.1 0.078 13.0 0.1 1.4 1 0 0 1 1 1 0 Septum formation inhibitor MinC, C-terminal domain TPR_6 PF13174.6 ETO30727.1 - 0.1 13.3 0.0 53 4.8 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat ER PF01133.17 ETO30727.1 - 0.19 11.7 4.0 0.1 12.6 1.6 1.9 2 0 0 2 2 2 0 Enhancer of rudimentary TPD PF14811.6 ETO30728.1 - 0.0004 20.3 0.0 0.001 18.9 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function TPD sequence-motif ATP-synt_8 PF00895.20 ETO30728.1 - 0.34 11.4 3.5 0.48 10.9 1.9 2.1 1 1 1 2 2 2 0 ATP synthase protein 8 ORC_WH_C PF18137.1 ETO30728.1 - 4.1 7.5 9.0 0.35 10.9 4.0 1.6 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal DUF3379 PF11859.8 ETO30729.1 - 0.081 12.2 0.2 0.15 11.4 0.1 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3379) PP-binding PF00550.25 ETO30730.1 - 6.1e-06 26.5 0.1 0.14 12.5 0.1 2.4 2 0 0 2 2 2 2 Phosphopantetheine attachment site Pet20 PF08692.10 ETO30730.1 - 0.051 14.3 0.0 0.092 13.5 0.0 1.4 1 0 0 1 1 1 0 Mitochondrial protein Pet20 PP-binding_2 PF14573.6 ETO30730.1 - 0.072 13.3 0.4 0.84 9.9 0.1 2.2 2 0 0 2 2 2 0 Acyl-carrier Rotamase PF00639.21 ETO30731.1 - 2.5e-18 66.8 1.8 4.6e-18 66.0 0.1 2.2 1 1 1 2 2 2 1 PPIC-type PPIASE domain Rotamase_3 PF13616.6 ETO30731.1 - 1.1e-14 55.0 0.3 3e-14 53.6 0.1 1.9 1 1 0 1 1 1 1 PPIC-type PPIASE domain FHA PF00498.26 ETO30731.1 - 5.8e-13 49.0 0.1 1.5e-12 47.6 0.1 1.8 1 0 0 1 1 1 1 FHA domain Rotamase_2 PF13145.6 ETO30731.1 - 0.00052 20.8 1.2 0.0019 19.0 1.2 2.1 1 1 0 1 1 1 1 PPIC-type PPIASE domain Yop-YscD_cpl PF16697.5 ETO30731.1 - 0.00097 19.4 0.0 0.0021 18.3 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain DUF4553 PF15090.6 ETO30731.1 - 0.0029 16.7 7.3 0.004 16.2 7.3 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4553) PHD PF00628.29 ETO30732.1 - 3.7e-08 33.1 7.1 8.3e-08 32.0 7.1 1.6 1 0 0 1 1 1 1 PHD-finger PHD_4 PF16866.5 ETO30732.1 - 0.0054 16.8 7.7 0.0054 16.8 7.7 2.7 2 1 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 ETO30732.1 - 0.017 15.3 4.5 0.017 15.3 4.5 2.0 2 0 0 2 2 2 0 PHD-like zinc-binding domain Zf_RING PF16744.5 ETO30732.1 - 0.047 13.8 4.6 0.11 12.6 4.6 1.7 1 0 0 1 1 1 0 KIAA1045 RING finger C1_2 PF03107.16 ETO30732.1 - 0.15 12.4 6.2 0.12 12.7 3.2 2.2 2 0 0 2 2 2 0 C1 domain AF-4 PF05110.13 ETO30732.1 - 0.27 9.3 38.9 0.29 9.2 38.9 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Prok-RING_1 PF14446.6 ETO30732.1 - 2.8 8.0 7.2 4.7 7.2 4.8 2.3 1 1 1 2 2 2 0 Prokaryotic RING finger family 1 DUF1771 PF08590.10 ETO30734.1 - 3.9e-20 72.0 3.8 6.9e-20 71.2 3.8 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1771) Torus PF16131.5 ETO30734.1 - 2.9e-06 28.0 2.9 0.00024 21.7 0.3 3.0 1 1 1 2 2 2 1 Torus domain zf_CCCH_4 PF18345.1 ETO30734.1 - 0.00012 22.0 16.6 0.00054 19.9 6.1 3.4 3 0 0 3 3 3 2 Zinc finger domain zf-CCCH_3 PF15663.5 ETO30734.1 - 0.00024 21.3 1.5 0.00066 19.9 1.5 1.7 1 0 0 1 1 1 1 Zinc-finger containing family Smr PF01713.21 ETO30734.1 - 0.00031 21.0 0.0 0.0086 16.4 0.0 2.4 2 0 0 2 2 2 1 Smr domain zf-CCCH PF00642.24 ETO30734.1 - 0.0014 18.5 3.9 0.14 12.1 0.1 2.4 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) FTCD PF02971.14 ETO30734.1 - 0.022 14.8 0.1 0.06 13.4 0.1 1.7 1 0 0 1 1 1 0 Formiminotransferase domain zf-CCCH_2 PF14608.6 ETO30734.1 - 0.028 14.9 6.3 0.4 11.2 0.9 2.6 2 0 0 2 2 2 0 RNA-binding, Nab2-type zinc finger DUF2847 PF11009.8 ETO30734.1 - 0.056 13.3 2.8 0.06 13.2 0.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2847) PhoU PF01895.19 ETO30734.1 - 0.074 13.5 0.2 0.21 12.1 0.2 1.8 1 0 0 1 1 1 0 PhoU domain zf-CCCH_4 PF18044.1 ETO30734.1 - 0.24 11.3 7.9 2 8.3 1.2 3.2 3 0 0 3 3 3 0 CCCH-type zinc finger Viral_env_E26 PF11050.8 ETO30734.1 - 6.2 6.1 10.9 0.1 11.9 2.2 2.1 2 0 0 2 2 2 0 Virus envelope protein E26 Torus PF16131.5 ETO30735.1 - 2.3e-05 25.1 2.8 0.14 12.8 0.0 2.4 1 1 1 2 2 2 2 Torus domain zf_CCCH_4 PF18345.1 ETO30735.1 - 0.00013 21.9 6.6 0.092 12.8 2.4 3.3 2 1 0 2 2 2 2 Zinc finger domain PAM2 PF07145.15 ETO30735.1 - 0.00016 21.1 0.2 0.00042 19.8 0.2 1.8 1 0 0 1 1 1 1 Ataxin-2 C-terminal region zf-CCCH_4 PF18044.1 ETO30735.1 - 0.00033 20.4 10.1 0.0013 18.5 2.0 2.8 3 0 0 3 3 3 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ETO30735.1 - 0.0043 17.5 5.5 0.39 11.3 0.1 2.7 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf-CCCH PF00642.24 ETO30735.1 - 0.0059 16.5 3.9 0.013 15.4 1.2 2.5 2 0 0 2 2 2 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_3 PF15663.5 ETO30735.1 - 0.0071 16.5 1.2 0.018 15.3 1.2 1.7 1 0 0 1 1 1 1 Zinc-finger containing family CUE PF02845.16 ETO30735.1 - 0.035 13.8 0.0 0.078 12.7 0.0 1.6 1 0 0 1 1 1 0 CUE domain zf-C3H1 PF10650.9 ETO30735.1 - 0.28 11.0 2.0 0.26 11.0 0.5 1.8 2 0 0 2 2 2 0 Putative zinc-finger domain DUF3791 PF12668.7 ETO30736.1 - 0.0083 16.2 0.4 0.017 15.1 0.4 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3791) DUF3439 PF11921.8 ETO30736.1 - 0.68 9.9 10.2 1.6 8.7 10.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) MCC-bdg_PDZ PF10506.9 ETO30737.1 - 0.0015 18.5 3.8 0.0015 18.5 3.8 3.3 2 1 1 3 3 3 1 PDZ domain of MCC-2 bdg protein for Usher syndrome KASH_CCD PF14662.6 ETO30737.1 - 0.013 15.4 11.1 0.013 15.4 11.1 2.6 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH DUF730 PF05325.11 ETO30737.1 - 0.039 14.0 0.6 0.039 14.0 0.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF730) Atg14 PF10186.9 ETO30737.1 - 0.066 12.3 21.6 0.9 8.6 21.6 2.0 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3584 PF12128.8 ETO30737.1 - 0.19 9.2 25.3 0.25 8.8 25.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) VWD PF00094.25 ETO30737.1 - 0.43 10.8 1.9 0.41 10.9 0.4 1.7 2 0 0 2 2 2 0 von Willebrand factor type D domain LPP PF04728.13 ETO30737.1 - 0.5 10.8 8.0 8 6.9 0.4 3.6 2 1 1 3 3 3 0 Lipoprotein leucine-zipper DUF3450 PF11932.8 ETO30737.1 - 0.58 9.4 27.2 0.46 9.7 6.3 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) HALZ PF02183.18 ETO30737.1 - 0.58 10.4 16.3 9.3 6.6 0.0 4.4 3 1 1 4 4 4 0 Homeobox associated leucine zipper CENP-F_leu_zip PF10473.9 ETO30737.1 - 0.69 9.9 36.8 8.3 6.4 16.7 2.8 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF4446 PF14584.6 ETO30737.1 - 1.1 9.3 13.1 0.62 10.0 2.5 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF4446) ADIP PF11559.8 ETO30737.1 - 1.3 9.1 27.1 0.5 10.4 5.9 2.8 2 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding SHE3 PF17078.5 ETO30737.1 - 1.4 8.6 26.0 2.9 7.5 6.1 2.2 2 0 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF1664 PF07889.12 ETO30737.1 - 1.5 8.9 17.8 1.8 8.6 3.9 2.8 1 1 1 3 3 3 0 Protein of unknown function (DUF1664) GAS PF13851.6 ETO30737.1 - 1.8 7.9 32.0 0.29 10.5 24.0 2.3 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding DUF812 PF05667.11 ETO30737.1 - 2.1 7.1 33.2 0.99 8.2 24.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Fib_alpha PF08702.10 ETO30737.1 - 2.2 8.5 17.3 1.1e+02 2.9 15.1 2.6 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Noelin-1 PF12308.8 ETO30737.1 - 2.2 8.3 8.0 0.53 10.3 1.7 2.7 1 1 2 3 3 3 0 Neurogenesis glycoprotein DASH_Dam1 PF08653.10 ETO30737.1 - 2.5 8.0 6.0 13 5.7 0.2 2.9 3 0 0 3 3 3 0 DASH complex subunit Dam1 TMPIT PF07851.13 ETO30737.1 - 2.9 7.0 21.0 3 7.0 5.9 2.2 1 1 1 2 2 2 0 TMPIT-like protein YabA PF06156.13 ETO30737.1 - 3.5 8.3 29.0 15 6.3 13.8 3.4 1 1 1 2 2 2 0 Initiation control protein YabA DUF745 PF05335.13 ETO30737.1 - 4.2 7.1 20.7 0.11 12.2 13.0 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF745) Nup54 PF13874.6 ETO30737.1 - 4.5 7.4 26.3 0.24 11.5 10.5 2.9 1 1 2 3 3 3 0 Nucleoporin complex subunit 54 FUSC PF04632.12 ETO30737.1 - 7.6 4.9 6.6 9.1 4.7 6.6 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family TPP1 PF10341.9 ETO30738.1 - 0.095 12.7 0.2 0.17 11.9 0.2 1.5 1 1 0 1 1 1 0 Shelterin complex subunit, TPP1/ACD Presenilin PF01080.17 ETO30740.1 - 3.9 6.1 5.4 4.3 6.0 5.4 1.1 1 0 0 1 1 1 0 Presenilin zf-TRAF PF02176.18 ETO30741.1 - 9.2e-05 23.1 5.9 0.00018 22.2 3.7 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger Peptidase_S46 PF10459.9 ETO30741.1 - 0.042 12.5 9.4 0.063 11.9 9.4 1.1 1 0 0 1 1 1 0 Peptidase S46 LMBR1 PF04791.16 ETO30741.1 - 2 7.2 6.8 3.3 6.5 6.8 1.4 1 0 0 1 1 1 0 LMBR1-like membrane protein Kelch_6 PF13964.6 ETO30742.1 - 4.1e-05 23.7 4.0 0.97 9.8 0.1 5.0 5 1 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO30742.1 - 0.00089 19.2 0.8 2.7 8.1 0.2 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO30742.1 - 0.001 18.9 0.4 0.63 10.1 0.1 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO30742.1 - 0.002 17.7 0.4 3.6 7.2 0.0 3.7 3 0 0 3 3 3 1 Kelch motif Alpha_L_fucos PF01120.17 ETO30743.1 - 1.4e-21 77.3 1.2 1.7e-20 73.8 1.2 2.0 1 1 0 1 1 1 1 Alpha-L-fucosidase UN_NPL4 PF11543.8 ETO30744.1 - 0.00016 22.1 0.0 0.0004 20.8 0.0 1.7 1 0 0 1 1 1 1 Nuclear pore localisation protein NPL4 SR-25 PF10500.9 ETO30744.1 - 0.0097 15.5 7.4 0.0097 15.5 7.4 3.0 3 0 0 3 3 3 1 Nuclear RNA-splicing-associated protein DUF4820 PF16091.5 ETO30744.1 - 1 8.6 13.5 0.46 9.8 7.9 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4820) Zip PF02535.22 ETO30744.1 - 4.1 6.5 8.8 0.95 8.6 5.1 1.8 2 1 0 2 2 2 0 ZIP Zinc transporter CAML PF14963.6 ETO30744.1 - 5.1 7.1 9.0 0.25 11.5 2.7 2.0 3 0 0 3 3 3 0 Calcium signal-modulating cyclophilin ligand DSPc PF00782.20 ETO30745.1 - 8e-06 25.7 0.0 2.1e-05 24.3 0.0 1.6 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Menin PF05053.13 ETO30746.1 - 0.039 12.3 0.2 0.048 12.0 0.2 1.1 1 0 0 1 1 1 0 Menin DUF3365 PF11845.8 ETO30747.1 - 0.57 10.5 4.6 0.17 12.2 1.5 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3365) PBP1_TM PF14812.6 ETO30748.1 - 9 6.8 6.1 8.9 6.8 0.3 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Ion_trans PF00520.31 ETO30749.1 - 2.8e-21 75.9 59.4 1.4e-17 63.7 21.0 3.5 3 0 0 3 3 3 3 Ion transport protein DUF4834 PF16118.5 ETO30749.1 - 0.00024 22.0 0.6 0.00024 22.0 0.6 4.5 4 1 0 4 4 4 1 Domain of unknown function (DUF4834) DUF1980 PF09323.10 ETO30749.1 - 0.0022 17.9 0.8 0.0022 17.9 0.8 3.2 4 0 0 4 4 4 1 Domain of unknown function (DUF1980) EF-hand_6 PF13405.6 ETO30749.1 - 0.011 15.5 1.0 6.1 7.1 0.3 3.0 2 0 0 2 2 2 0 EF-hand domain EF-hand_1 PF00036.32 ETO30749.1 - 0.3 10.7 2.6 2.9 7.6 1.0 2.6 2 0 0 2 2 2 0 EF hand L31 PF09784.9 ETO30750.1 - 0.015 15.7 4.5 0.015 15.7 4.5 2.4 3 0 0 3 3 3 0 Mitochondrial ribosomal protein L31 DMRT-like PF15791.5 ETO30750.1 - 0.21 12.0 1.2 0.49 10.8 1.2 1.6 1 0 0 1 1 1 0 Doublesex-and mab-3-related transcription factor C1 and C2 WD40 PF00400.32 ETO30752.1 - 1.5e-36 123.7 9.5 1.3e-08 35.4 0.4 6.1 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30752.1 - 1.5e-10 41.2 3.0 0.0015 18.8 0.1 3.6 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO30752.1 - 1.9e-08 34.0 3.1 0.00014 21.3 0.4 3.0 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO30752.1 - 2.9e-07 29.8 0.4 0.031 13.2 0.0 3.2 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO30752.1 - 1.5e-06 27.2 3.3 0.1 11.2 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO30752.1 - 0.004 16.0 5.7 0.97 8.1 0.4 3.1 1 1 1 3 3 3 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO30752.1 - 0.021 13.4 0.3 0.26 9.8 0.1 2.1 1 1 0 2 2 2 0 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO30752.1 - 0.031 14.4 0.8 0.25 11.5 0.1 2.2 1 1 0 2 2 2 0 Family of unknown function (DUF5570) Evr1_Alr PF04777.13 ETO30753.1 - 7.7e-21 74.4 0.5 1.1e-20 73.9 0.5 1.3 1 0 0 1 1 1 1 Erv1 / Alr family Zn_ribbon_recom PF13408.6 ETO30753.1 - 0.011 16.2 0.1 0.024 15.2 0.0 1.6 1 1 0 1 1 1 0 Recombinase zinc beta ribbon domain GIT_SHD PF08518.11 ETO30753.1 - 0.2 11.3 0.4 0.38 10.4 0.4 1.4 1 0 0 1 1 1 0 Spa2 homology domain (SHD) of GIT ART PF01129.18 ETO30754.1 - 0.068 12.4 0.0 0.25 10.6 0.0 2.0 2 0 0 2 2 2 0 NAD:arginine ADP-ribosyltransferase PUB PF09409.10 ETO30754.1 - 0.1 12.6 3.6 0.3 11.0 0.2 3.0 2 1 0 2 2 2 0 PUB domain Lung_7-TM_R PF06814.13 ETO30755.1 - 4.2e-44 151.0 16.1 3.1e-43 148.1 16.1 1.9 1 1 0 1 1 1 1 Lung seven transmembrane receptor Myco_arth_vir_N PF09610.10 ETO30755.1 - 2.3 8.4 10.2 0.63 10.2 0.7 3.9 3 0 0 3 3 3 0 Mycoplasma virulence signal region (Myco_arth_vir_N) VKOR PF07884.14 ETO30755.1 - 7.7 6.7 15.8 2 8.6 2.2 2.7 2 1 0 2 2 2 0 Vitamin K epoxide reductase family G-alpha PF00503.20 ETO30756.1 - 3.5e-22 79.0 1.6 7.6e-22 77.9 1.6 1.6 1 1 0 1 1 1 1 G-protein alpha subunit G-alpha PF00503.20 ETO30757.1 - 3.8e-42 144.7 1.4 4.2e-42 144.6 1.4 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO30757.1 - 2.6e-10 40.0 0.1 4.3e-10 39.3 0.1 1.3 1 1 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO30757.1 - 0.045 13.1 0.2 0.058 12.7 0.2 1.1 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region RPEL PF02755.15 ETO30759.1 - 3.3e-10 39.3 79.7 0.21 11.3 0.1 20.6 25 0 0 25 25 25 11 RPEL repeat PspB PF06667.12 ETO30759.1 - 0.029 14.4 3.8 2 8.5 0.0 3.8 2 1 1 3 3 3 0 Phage shock protein B Pyridoxal_deC PF00282.19 ETO30760.1 - 7.7e-57 192.7 0.0 9.8e-47 159.4 0.0 2.5 3 0 0 3 3 3 2 Pyridoxal-dependent decarboxylase conserved domain Aminotran_1_2 PF00155.21 ETO30760.1 - 6.2e-06 25.6 0.0 1.3e-05 24.6 0.0 1.5 1 0 0 1 1 1 1 Aminotransferase class I and II SepSecS PF05889.13 ETO30760.1 - 0.00053 18.8 0.0 0.001 17.9 0.0 1.4 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Beta_elim_lyase PF01212.21 ETO30760.1 - 0.00065 19.1 0.0 0.00094 18.5 0.0 1.2 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ETO30760.1 - 0.0013 17.8 0.0 0.0041 16.1 0.0 1.8 1 1 0 1 1 1 1 Aminotransferase class-V MFS_1 PF07690.16 ETO30762.1 - 0.88 8.4 8.6 0.12 11.2 1.4 2.0 1 1 1 2 2 2 0 Major Facilitator Superfamily NTP_transf_2 PF01909.23 ETO30763.1 - 1.7e-08 34.6 0.4 4.9e-08 33.2 0.1 1.9 2 0 0 2 2 2 1 Nucleotidyltransferase domain zf_CCCH_4 PF18345.1 ETO30763.1 - 2.1e-06 27.6 11.6 0.0055 16.7 3.6 2.9 2 0 0 2 2 2 2 Zinc finger domain PAP_assoc PF03828.19 ETO30763.1 - 2.3e-06 27.7 0.7 5.2e-05 23.4 0.5 3.2 2 1 0 2 2 2 1 Cid1 family poly A polymerase zf-CCCH PF00642.24 ETO30763.1 - 0.0078 16.1 10.4 0.23 11.4 1.3 2.5 2 0 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Polbeta PF18765.1 ETO30763.1 - 0.009 16.1 0.1 0.029 14.4 0.0 1.9 2 0 0 2 2 2 1 Polymerase beta, Nucleotidyltransferase zf-CCCH_4 PF18044.1 ETO30763.1 - 0.057 13.2 9.9 0.77 9.6 2.6 2.5 2 0 0 2 2 2 0 CCCH-type zinc finger UPF0669 PF17065.5 ETO30763.1 - 0.11 12.3 0.0 0.28 10.9 0.0 1.7 1 0 0 1 1 1 0 Putative cytokine, C6ORF120 zf-CCCH_3 PF15663.5 ETO30763.1 - 0.15 12.3 3.1 0.33 11.2 0.3 2.5 2 0 0 2 2 2 0 Zinc-finger containing family GATase PF00117.28 ETO30764.1 - 1.3e-06 28.3 0.0 1.9e-06 27.8 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase class-I Peptidase_C26 PF07722.13 ETO30764.1 - 4.5e-05 23.3 0.0 0.0002 21.2 0.0 2.1 1 1 0 1 1 1 1 Peptidase C26 GATase_5 PF13507.6 ETO30764.1 - 0.0032 16.6 0.0 1.1 8.3 0.0 2.1 2 0 0 2 2 2 2 CobB/CobQ-like glutamine amidotransferase domain SNO PF01174.19 ETO30764.1 - 0.018 14.9 0.0 0.07 13.0 0.0 1.8 2 0 0 2 2 2 0 SNO glutamine amidotransferase family Molybdop_Fe4S4 PF04879.16 ETO30764.1 - 0.045 13.7 0.0 0.13 12.3 0.0 1.8 2 0 0 2 2 2 0 Molybdopterin oxidoreductase Fe4S4 domain PPR PF01535.20 ETO30765.1 - 1.8e-09 37.2 4.5 0.21 11.9 0.1 4.6 4 0 0 4 4 4 4 PPR repeat PPR_2 PF13041.6 ETO30765.1 - 9e-08 32.2 4.3 0.031 14.5 0.0 3.7 2 1 2 4 4 4 3 PPR repeat family PPR_3 PF13812.6 ETO30765.1 - 3.1e-05 23.9 0.0 0.0031 17.6 0.0 3.2 2 1 1 3 3 3 1 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO30765.1 - 0.041 13.2 0.2 2.6 7.3 0.1 2.1 1 1 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP Peptidase_M16 PF00675.20 ETO30766.1 - 1e-41 142.4 0.1 1.4e-41 142.0 0.1 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) KAsynt_C_assoc PF16197.5 ETO30766.1 - 0.011 16.2 0.3 0.067 13.6 0.1 2.2 2 0 0 2 2 2 0 Ketoacyl-synthetase C-terminal extension WD40 PF00400.32 ETO30767.1 - 1.9e-32 110.8 12.7 2.8e-07 31.1 0.2 7.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30767.1 - 4.2e-11 43.0 3.0 0.66 10.3 0.0 5.2 2 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO30767.1 - 4.8e-06 25.5 1.4 0.15 10.7 0.1 3.4 3 0 0 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO30767.1 - 0.00016 20.7 0.1 0.002 17.2 0.0 2.6 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO30767.1 - 0.00032 19.6 3.6 0.038 12.7 0.1 3.8 1 1 1 3 3 3 1 Nup133 N terminal like PQQ_2 PF13360.6 ETO30767.1 - 0.002 17.7 0.0 0.0065 16.1 0.0 1.9 2 1 0 2 2 2 1 PQQ-like domain Hira PF07569.11 ETO30767.1 - 0.043 13.5 0.1 4.7 6.9 0.0 3.5 2 1 0 2 2 2 0 TUP1-like enhancer of split U-box PF04564.15 ETO30768.1 - 1.1e-15 57.6 0.0 1.6e-15 57.0 0.0 1.3 1 0 0 1 1 1 1 U-box domain SAM_1 PF00536.30 ETO30768.1 - 1.9e-06 28.2 0.3 2.3e-05 24.7 0.2 2.1 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO30768.1 - 0.00041 20.4 0.3 0.00082 19.4 0.1 1.6 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) zf-Nse PF11789.8 ETO30768.1 - 0.027 14.3 0.0 0.05 13.4 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit RRM_1 PF00076.22 ETO30769.1 - 5.6e-24 83.7 0.1 1.6e-14 53.5 0.0 3.4 3 0 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO30769.1 - 3.5e-05 23.4 0.5 0.012 15.2 0.0 2.8 3 0 0 3 3 3 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Ribosomal_L29e PF01779.17 ETO30770.1 - 2.8e-22 78.7 7.2 6.5e-22 77.6 7.2 1.6 1 0 0 1 1 1 1 Ribosomal L29e protein family DUF382 PF04037.13 ETO30770.1 - 0.04 14.1 2.2 0.048 13.8 2.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF382) DUF3959 PF13105.6 ETO30770.1 - 0.12 11.8 2.6 0.15 11.6 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) Peptidase_M16_C PF05193.21 ETO30772.1 - 4.1e-12 46.5 0.0 6.1e-12 45.9 0.0 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain BBP2 PF07642.11 ETO30772.1 - 0.0078 15.4 0.0 0.016 14.4 0.0 1.5 2 0 0 2 2 2 1 Putative beta-barrel porin-2, OmpL-like. bbp2 Peptidase_M16_C PF05193.21 ETO30773.1 - 1.4e-12 48.1 0.1 2.1e-12 47.4 0.1 1.3 1 0 0 1 1 1 1 Peptidase M16 inactive domain Peptidase_M16 PF00675.20 ETO30773.1 - 0.079 12.9 0.0 0.22 11.5 0.0 1.7 2 0 0 2 2 2 0 Insulinase (Peptidase family M16) HJURP_C PF12347.8 ETO30773.1 - 0.23 11.5 1.2 1.8 8.7 0.3 2.2 2 0 0 2 2 2 0 Holliday junction regulator protein family C-terminal repeat Glyco_transf_20 PF00982.21 ETO30774.1 - 3.4e-99 332.7 0.1 4.6e-99 332.3 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 20 Trehalose_PPase PF02358.16 ETO30774.1 - 3.2e-26 91.9 0.0 8.1e-26 90.6 0.0 1.6 2 0 0 2 2 2 1 Trehalose-phosphatase CBS PF00571.28 ETO30775.1 - 5.5e-14 52.3 0.0 2.6e-11 43.8 0.1 2.5 2 1 0 2 2 2 2 CBS domain FAM219A PF15260.6 ETO30775.1 - 0.022 15.1 0.0 0.028 14.8 0.0 1.1 1 0 0 1 1 1 0 Protein family FAM219A Ssu72 PF04722.13 ETO30775.1 - 0.082 12.5 0.1 0.1 12.1 0.1 1.1 1 0 0 1 1 1 0 Ssu72-like protein DUF3947 PF13135.6 ETO30775.1 - 0.18 12.0 0.0 0.29 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3947) B56 PF01603.20 ETO30778.1 - 5.8e-106 354.9 7.2 7.7e-106 354.5 7.2 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Rav1p_C PF12234.8 ETO30780.1 - 1.1e-32 113.4 9.5 6.8e-24 84.2 3.0 3.5 2 1 0 2 2 2 2 RAVE protein 1 C terminal WD40 PF00400.32 ETO30780.1 - 0.0004 21.1 2.7 0.15 13.0 0.2 4.5 4 0 0 4 4 4 1 WD domain, G-beta repeat Menin PF05053.13 ETO30780.1 - 0.027 12.8 31.0 0.021 13.2 3.5 3.2 3 0 0 3 3 3 0 Menin F-box_4 PF15966.5 ETO30780.1 - 0.2 11.5 6.2 0.11 12.4 0.6 2.7 2 0 0 2 2 2 0 F-box BAF1_ABF1 PF04684.13 ETO30780.1 - 2.6 7.0 40.1 0.47 9.5 7.1 3.2 3 0 0 3 3 3 0 BAF1 / ABF1 chromatin reorganising factor CDC45 PF02724.14 ETO30781.1 - 0.0024 16.2 4.9 0.0024 16.2 4.9 2.2 2 0 0 2 2 2 1 CDC45-like protein Vfa1 PF08432.10 ETO30781.1 - 0.084 13.2 24.0 0.93 9.8 16.9 3.4 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 RNA_polI_A34 PF08208.11 ETO30781.1 - 0.68 10.0 19.4 1.9 8.5 19.4 1.7 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 MID_MedPIWI PF18296.1 ETO30781.1 - 0.77 9.5 16.2 1.1 9.0 0.2 4.1 4 0 0 4 4 4 0 MID domain of medPIWI Eapp_C PF10238.9 ETO30781.1 - 1.3 9.1 15.0 0.15 12.1 5.6 2.7 2 0 0 2 2 2 0 E2F-associated phosphoprotein ORC_WH_C PF18137.1 ETO30781.1 - 6 6.9 14.0 20 5.2 0.0 2.6 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal Guanylate_cyc PF00211.20 ETO30782.1 - 1.1e-05 25.1 0.0 2e-05 24.3 0.0 1.4 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain Choline_transpo PF04515.12 ETO30783.1 - 4.5e-75 252.8 22.0 4.5e-75 252.8 22.0 2.3 2 1 0 2 2 2 1 Plasma-membrane choline transporter ECSCR PF15820.5 ETO30783.1 - 0.06 13.2 0.1 11 5.9 0.0 2.7 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator WD40 PF00400.32 ETO30784.1 - 2e-35 120.2 20.5 1.8e-06 28.6 0.5 7.4 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30784.1 - 9.6e-12 45.0 0.3 0.027 14.7 0.0 5.1 6 0 0 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO30784.1 - 3e-07 29.5 4.6 0.014 14.1 0.2 3.6 2 1 1 4 4 4 3 Nucleoporin Nup120/160 Peptidase_C14 PF00656.22 ETO30785.1 - 2.5e-12 47.3 0.4 4.6e-12 46.4 0.4 1.4 1 1 0 1 1 1 1 Caspase domain Phage_int_SAM_4 PF13495.6 ETO30785.1 - 0.002 18.5 0.0 0.0055 17.2 0.0 1.6 1 0 0 1 1 1 1 Phage integrase, N-terminal SAM-like domain ANAPC2 PF08672.11 ETO30785.1 - 0.14 12.7 0.1 0.84 10.2 0.0 2.1 2 0 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 Kelch_5 PF13854.6 ETO30786.1 - 9.1e-05 22.4 0.6 1.2 9.2 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO30786.1 - 0.00079 19.0 7.0 0.053 13.1 0.1 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO30786.1 - 0.0016 18.6 2.3 4.2 7.8 0.3 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO30786.1 - 0.0023 17.8 5.7 1.6 8.8 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO30786.1 - 0.1 12.9 0.2 1.2 9.6 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO30786.1 - 0.17 11.9 0.1 1.4 9.0 0.0 2.6 3 0 0 3 3 3 0 Galactose oxidase, central domain PulA_N1 PF17999.1 ETO30786.1 - 2.7 8.8 5.2 9.1 7.1 0.1 3.1 3 0 0 3 3 3 0 Pullulanase N1-terminal domain DNA_pol_phi PF04931.13 ETO30788.1 - 2.7 6.0 8.0 4 5.4 8.0 1.2 1 0 0 1 1 1 0 DNA polymerase phi Mucin PF01456.17 ETO30788.1 - 2.8 7.9 22.2 5.5 7.0 22.2 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein NOA36 PF06524.12 ETO30788.1 - 3.6 6.8 5.6 1.5 8.1 3.0 1.6 2 0 0 2 2 2 0 NOA36 protein PT PF04886.12 ETO30789.1 - 0.003 17.0 17.1 0.003 17.0 17.1 2.7 2 0 0 2 2 2 2 PT repeat Ion_trans PF00520.31 ETO30790.1 - 8.5e-11 41.5 23.0 8.5e-11 41.5 23.0 2.2 2 0 0 2 2 2 1 Ion transport protein 60KD_IMP PF02096.20 ETO30790.1 - 3.1 7.7 6.4 2.2 8.2 3.5 2.3 2 1 0 2 2 2 0 60Kd inner membrane protein VPS9 PF02204.18 ETO30791.1 - 0.0048 17.1 0.0 0.012 15.9 0.0 1.7 1 0 0 1 1 1 1 Vacuolar sorting protein 9 (VPS9) domain PRD PF00874.20 ETO30791.1 - 3.3 8.1 6.9 32 4.9 0.0 3.9 2 2 2 4 4 4 0 PRD domain VWA_3 PF13768.6 ETO30792.1 - 0.013 15.5 0.0 0.033 14.1 0.0 1.7 1 0 0 1 1 1 0 von Willebrand factor type A domain Vma12 PF11712.8 ETO30793.1 - 1.7e-17 63.8 0.0 2.9e-17 63.0 0.0 1.3 1 0 0 1 1 1 1 Endoplasmic reticulum-based factor for assembly of V-ATPase DUF2207 PF09972.9 ETO30793.1 - 0.0078 15.0 0.0 0.0087 14.9 0.0 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Cation_efflux PF01545.21 ETO30793.1 - 0.056 13.2 0.1 0.075 12.8 0.1 1.1 1 0 0 1 1 1 0 Cation efflux family LapA_dom PF06305.11 ETO30793.1 - 0.77 9.6 3.5 6.4 6.7 0.0 2.6 3 0 0 3 3 3 0 Lipopolysaccharide assembly protein A domain DUF2852 PF11014.8 ETO30793.1 - 1.3 9.2 4.2 0.58 10.3 0.8 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF2852) TGT PF01702.18 ETO30794.1 - 2e-63 214.7 0.0 2.5e-63 214.4 0.0 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase TGT PF01702.18 ETO30795.1 - 3.2e-63 214.0 0.6 3.8e-63 213.8 0.6 1.0 1 0 0 1 1 1 1 Queuine tRNA-ribosyltransferase Josephin PF02099.17 ETO30796.1 - 2.5e-10 40.7 0.3 3.3e-10 40.3 0.3 1.2 1 0 0 1 1 1 1 Josephin Sulfotransfer_2 PF03567.14 ETO30798.1 - 1.9e-08 34.5 6.3 1.1e-07 32.1 2.3 2.4 2 1 0 2 2 2 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 ETO30798.1 - 2.1e-05 24.1 5.8 0.0003 20.4 2.3 3.1 2 2 1 3 3 3 2 Sulfotransferase domain IL5 PF02025.15 ETO30798.1 - 0.063 13.6 0.8 0.3 11.4 0.3 2.3 2 0 0 2 2 2 0 Interleukin 5 CDC45 PF02724.14 ETO30799.1 - 0.02 13.2 6.0 0.029 12.7 4.5 1.9 2 0 0 2 2 2 0 CDC45-like protein EF-hand_7 PF13499.6 ETO30800.1 - 0.0016 18.9 0.6 0.15 12.5 0.0 3.0 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO30800.1 - 0.01 15.3 0.0 0.25 11.0 0.0 2.7 2 0 0 2 2 2 0 EF hand EF-hand_6 PF13405.6 ETO30800.1 - 0.011 15.6 0.1 2.6 8.2 0.0 2.7 2 0 0 2 2 2 0 EF-hand domain ANXA2R PF15721.5 ETO30800.1 - 0.046 14.2 0.9 0.046 14.2 0.9 1.6 2 0 0 2 2 2 0 Annexin-2 receptor SesA PF17107.5 ETO30800.1 - 0.39 10.9 5.9 0.1 12.8 2.1 1.9 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases TBP PF00352.21 ETO30802.1 - 8.8e-21 73.7 0.2 2.4e-11 43.4 0.3 2.5 3 0 0 3 3 3 2 Transcription factor TFIID (or TATA-binding protein, TBP) MucB_RseB PF03888.14 ETO30802.1 - 0.014 14.9 0.0 0.024 14.2 0.0 1.3 1 0 0 1 1 1 0 MucB/RseB N-terminal domain G-alpha PF00503.20 ETO30803.1 - 4e-23 82.1 0.4 5.3e-23 81.7 0.4 1.1 1 0 0 1 1 1 1 G-protein alpha subunit ABC_tran PF00005.27 ETO30803.1 - 0.0016 19.0 0.3 0.0023 18.5 0.3 1.3 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 ETO30803.1 - 0.0018 18.8 0.0 0.0033 17.9 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_33 PF13671.6 ETO30803.1 - 0.11 12.7 0.0 0.17 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain Bax1-I PF01027.20 ETO30805.1 - 3.7e-27 95.5 6.0 5.8e-27 94.9 6.0 1.3 1 1 0 1 1 1 1 Inhibitor of apoptosis-promoting Bax1 CCSAP PF15748.5 ETO30806.1 - 0.86 9.7 8.1 0.82 9.8 7.4 1.3 1 1 0 1 1 1 0 Centriole, cilia and spindle-associated CLN3 PF02487.17 ETO30807.1 - 0.049 12.7 0.0 0.06 12.4 0.0 1.2 1 0 0 1 1 1 0 CLN3 protein Orf78 PF06024.12 ETO30807.1 - 0.18 12.1 3.1 3.4 8.0 0.0 2.2 2 0 0 2 2 2 0 Orf78 (ac78) DUF4692 PF15763.5 ETO30808.1 - 0.018 15.5 0.3 0.035 14.6 0.0 1.5 2 0 0 2 2 2 0 Regulator of human erythroid cell expansion (RHEX) zf-H2C2 PF09337.10 ETO30809.1 - 0.0021 18.2 0.1 0.0046 17.1 0.1 1.6 1 0 0 1 1 1 1 H2C2 zinc finger Integrase_H2C2 PF17921.1 ETO30809.1 - 0.055 13.6 0.5 0.098 12.8 0.5 1.4 1 0 0 1 1 1 0 Integrase zinc binding domain DUF4980 PF16352.5 ETO30809.1 - 0.058 13.4 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4980) Ax_dynein_light PF10211.9 ETO30810.1 - 0.0011 18.9 3.1 0.0019 18.2 3.1 1.3 1 0 0 1 1 1 1 Axonemal dynein light chain GNT-I PF03071.15 ETO30810.1 - 0.0088 14.8 0.1 0.011 14.5 0.1 1.2 1 0 0 1 1 1 1 GNT-I family Glycos_transf_2 PF00535.26 ETO30810.1 - 0.026 14.3 0.0 0.071 12.9 0.0 1.7 1 0 0 1 1 1 0 Glycosyl transferase family 2 ZapB PF06005.12 ETO30810.1 - 0.03 14.8 2.5 0.081 13.4 2.5 1.7 1 0 0 1 1 1 0 Cell division protein ZapB Semenogelin PF05474.11 ETO30810.1 - 0.053 12.1 0.7 0.072 11.6 0.7 1.1 1 0 0 1 1 1 0 Semenogelin HALZ PF02183.18 ETO30810.1 - 0.23 11.7 3.0 0.52 10.6 3.0 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper DivIC PF04977.15 ETO30810.1 - 0.24 11.2 6.0 0.18 11.6 2.8 2.2 2 0 0 2 2 2 0 Septum formation initiator GNT-I PF03071.15 ETO30811.1 - 3e-93 312.9 7.5 4e-93 312.6 7.5 1.0 1 0 0 1 1 1 1 GNT-I family NAPRTase_N PF17767.1 ETO30811.1 - 0.39 11.1 3.9 1 9.8 0.2 2.7 2 1 1 3 3 3 0 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain Ribosomal_L15e PF00827.17 ETO30813.1 - 1.6e-63 213.9 2.9 3.2e-63 212.9 2.9 1.5 1 0 0 1 1 1 1 Ribosomal L15 SANT_DAMP1_like PF16282.5 ETO30814.1 - 1.7e-21 76.2 5.9 2.4e-17 62.9 0.7 3.1 3 0 0 3 3 3 2 SANT/Myb-like domain of DAMP1 LmjF365940-deam PF14421.6 ETO30815.1 - 3e-39 134.6 0.0 4.2e-39 134.2 0.0 1.1 1 0 0 1 1 1 1 A distinct subfamily of CDD/CDA-like deaminases dCMP_cyt_deam_1 PF00383.23 ETO30815.1 - 0.013 15.4 0.1 0.21 11.5 0.0 2.2 2 0 0 2 2 2 0 Cytidine and deoxycytidylate deaminase zinc-binding region RCC1_2 PF13540.6 ETO30816.1 - 4.4e-07 29.5 1.9 0.012 15.4 0.1 3.5 3 0 0 3 3 3 2 Regulator of chromosome condensation (RCC1) repeat RCC1 PF00415.18 ETO30816.1 - 7.2e-06 26.5 6.9 3.2e-05 24.5 0.1 4.0 4 1 0 4 4 4 1 Regulator of chromosome condensation (RCC1) repeat sCache_like PF16736.5 ETO30816.1 - 0.16 12.1 3.0 0.2 11.8 0.1 2.3 2 0 0 2 2 2 0 Single Cache-like DUF2312 PF10073.9 ETO30818.1 - 0.065 12.9 4.4 0.43 10.3 0.0 3.2 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2312) NT5C PF06941.12 ETO30819.1 - 4.6e-06 26.6 0.7 1.6e-05 24.8 0.1 2.2 2 1 0 2 2 2 1 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C) HAD_2 PF13419.6 ETO30819.1 - 0.0049 17.0 0.0 0.0075 16.4 0.0 1.4 1 0 0 1 1 1 1 Haloacid dehalogenase-like hydrolase CID_GANP PF16766.5 ETO30819.1 - 0.093 12.9 0.4 0.72 10.1 0.0 2.2 2 0 0 2 2 2 0 Binding region of GANP to ENY2 NitrOD2 PF18550.1 ETO30819.1 - 0.1 12.8 0.0 0.4 10.8 0.0 1.9 2 0 0 2 2 2 0 Nitrososphaera output domain 2 zf-UBP PF02148.19 ETO30821.1 - 3.8e-13 49.6 0.4 1.2e-12 47.9 0.0 2.1 3 0 0 3 3 3 1 Zn-finger in ubiquitin-hydrolases and other protein UCH PF00443.29 ETO30821.1 - 1.3e-10 41.2 0.0 2.4e-10 40.4 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO30821.1 - 0.0099 15.5 0.3 0.014 15.0 0.3 1.3 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO30822.1 - 4.9e-21 75.4 0.1 7.9e-21 74.7 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA PF00627.31 ETO30822.1 - 1.3e-10 41.0 2.3 0.00012 21.9 0.1 2.4 2 0 0 2 2 2 2 UBA/TS-N domain UCH_1 PF13423.6 ETO30822.1 - 1.8e-09 37.7 1.6 2.6e-08 33.8 1.6 2.2 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UBA_2 PF08587.11 ETO30822.1 - 0.013 15.6 0.7 0.056 13.6 0.0 2.4 3 0 0 3 3 2 0 Ubiquitin associated domain (UBA) DUF3464 PF11947.8 ETO30822.1 - 0.065 13.0 0.5 0.13 12.0 0.5 1.5 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 DUF2956 PF11169.8 ETO30822.1 - 0.098 12.9 4.7 0.24 11.6 4.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) Hepsin-SRCR PF09272.10 ETO30822.1 - 0.12 12.9 0.1 4.6 7.8 0.0 2.4 2 0 0 2 2 2 0 Hepsin, SRCR domain Radial_spoke PF04712.12 ETO30822.1 - 0.44 9.4 7.9 0.72 8.7 7.9 1.2 1 0 0 1 1 1 0 Radial spokehead-like protein TRAP_alpha PF03896.16 ETO30822.1 - 0.46 9.6 3.0 0.6 9.3 1.7 1.8 2 0 0 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit DUF3915 PF13054.6 ETO30822.1 - 0.58 10.1 4.9 1.2 9.1 4.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) Connexin PF00029.19 ETO30822.1 - 1.1 9.0 2.9 1.9 8.2 2.9 1.4 1 0 0 1 1 1 0 Connexin AAA_23 PF13476.6 ETO30822.1 - 1.2 9.6 11.9 4.3 7.8 10.8 2.0 2 0 0 2 2 2 0 AAA domain Peptidase_S49_N PF08496.10 ETO30822.1 - 1.3 9.1 6.3 1.9 8.6 4.9 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Atrophin-1 PF03154.15 ETO30822.1 - 1.8 6.8 11.5 2.8 6.1 11.5 1.2 1 0 0 1 1 1 0 Atrophin-1 family OAD_gamma PF04277.13 ETO30822.1 - 2.3 8.9 6.7 92 3.7 5.0 2.8 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF1840 PF08895.11 ETO30822.1 - 3.8 7.9 6.2 12 6.3 4.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Vfa1 PF08432.10 ETO30822.1 - 5.2 7.4 13.8 0.4 11.0 7.5 2.1 2 1 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 EIIBC-GUT_N PF03612.14 ETO30822.1 - 6.7 6.4 7.6 4.4 7.0 4.3 2.0 2 0 0 2 2 2 0 Sorbitol phosphotransferase enzyme II N-terminus SdiA-regulated PF06977.11 ETO30824.1 - 0.084 12.1 0.1 0.096 11.9 0.1 1.1 1 0 0 1 1 1 0 SdiA-regulated MmgE_PrpD PF03972.14 ETO30825.1 - 8.8e-05 21.2 0.0 0.00011 20.9 0.0 1.1 1 0 0 1 1 1 1 MmgE/PrpD family BUD22 PF09073.10 ETO30826.1 - 0.0033 16.9 16.1 0.0042 16.5 16.1 1.2 1 0 0 1 1 1 1 BUD22 Zip PF02535.22 ETO30826.1 - 1.1 8.4 14.0 4.1e+02 -0.0 14.0 2.1 1 1 0 1 1 1 0 ZIP Zinc transporter PBP1_TM PF14812.6 ETO30826.1 - 2.4 8.6 17.8 6.2 7.3 0.7 2.5 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal CDC45 PF02724.14 ETO30826.1 - 2.6 6.2 18.9 0.46 8.7 13.2 1.9 2 0 0 2 2 2 0 CDC45-like protein DUF4746 PF15928.5 ETO30826.1 - 3.2 7.1 24.5 9.7 5.5 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) Prothymosin PF03247.14 ETO30826.1 - 3.4 8.2 33.8 3.7 8.0 22.6 2.2 2 0 0 2 2 2 0 Prothymosin/parathymosin family PNISR PF15996.5 ETO30826.1 - 9 6.5 23.6 10 6.3 0.5 2.1 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Dynein_light PF01221.18 ETO30827.1 - 7.3e-34 116.0 6.8 3.8e-33 113.6 6.8 2.0 1 1 0 1 1 1 1 Dynein light chain type 1 Pkinase PF00069.25 ETO30828.1 - 2.3e-14 53.4 0.8 3.4e-14 52.9 0.8 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30828.1 - 8.9e-10 38.3 0.4 1.3e-09 37.8 0.4 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 ETO30828.1 - 0.0013 18.9 0.1 0.0023 18.1 0.1 1.5 1 0 0 1 1 1 1 ABC1 family zinc_ribbon_2 PF13240.6 ETO30828.1 - 0.0052 16.5 0.1 0.01 15.5 0.1 1.4 1 0 0 1 1 1 1 zinc-ribbon domain zf-ribbon_3 PF13248.6 ETO30828.1 - 0.08 12.4 0.2 0.14 11.6 0.2 1.4 1 0 0 1 1 1 0 zinc-ribbon domain HIPIP PF01355.17 ETO30828.1 - 0.088 13.2 0.0 0.18 12.2 0.0 1.5 1 0 0 1 1 1 0 High potential iron-sulfur protein zf-NADH-PPase PF09297.11 ETO30828.1 - 0.11 12.2 0.1 0.2 11.4 0.1 1.3 1 0 0 1 1 1 0 NADH pyrophosphatase zinc ribbon domain DZR PF12773.7 ETO30828.1 - 0.11 12.5 0.0 0.19 11.8 0.0 1.4 1 0 0 1 1 1 0 Double zinc ribbon Nudix_N_2 PF14803.6 ETO30828.1 - 0.13 12.2 0.5 0.25 11.3 0.5 1.4 1 0 0 1 1 1 0 Nudix N-terminal CHIP_TPR_N PF18391.1 ETO30829.1 - 1 10.1 8.8 0.14 12.9 3.3 2.3 1 1 2 3 3 3 0 CHIP N-terminal tetratricopeptide repeat domain Sec6 PF06046.13 ETO30830.1 - 4.3e-06 25.4 0.2 4.3e-06 25.4 0.2 2.2 3 0 0 3 3 3 1 Exocyst complex component Sec6 DUF3767 PF12597.8 ETO30830.1 - 0.052 13.4 1.2 8.1 6.3 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3767) ILEI PF15711.5 ETO30830.1 - 0.077 13.5 1.3 0.69 10.4 0.1 3.2 3 1 0 3 3 3 0 Interleukin-like EMT inducer Afi1 PF07792.12 ETO30830.1 - 0.09 13.3 7.3 0.048 14.1 1.8 2.6 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_Rpc4 PF05132.14 ETO30830.1 - 9.5 6.6 9.1 0.32 11.4 2.4 1.9 2 0 0 2 2 2 0 RNA polymerase III RPC4 zf-RanBP PF00641.18 ETO30831.1 - 0.00027 20.2 4.3 0.00027 20.2 4.3 4.2 4 0 0 4 4 4 1 Zn-finger in Ran binding protein and others Utp14 PF04615.13 ETO30831.1 - 0.00055 18.7 27.5 0.00055 18.7 27.5 2.1 2 0 0 2 2 2 2 Utp14 protein ID PF18543.1 ETO30831.1 - 0.039 14.0 0.0 0.12 12.4 0.0 1.8 1 0 0 1 1 1 0 Intracellular delivery domain C1_2 PF03107.16 ETO30832.1 - 0.00034 20.8 5.0 0.00034 20.8 5.0 1.8 2 0 0 2 2 2 1 C1 domain ZZ PF00569.17 ETO30832.1 - 0.0044 16.8 6.7 0.009 15.8 6.7 1.6 1 0 0 1 1 1 1 Zinc finger, ZZ type PARP PF00644.20 ETO30832.1 - 0.028 14.0 0.3 0.099 12.2 0.3 1.9 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain PUF PF00806.19 ETO30833.1 - 1.1e-48 160.2 15.9 9.5e-08 31.3 0.3 8.6 8 0 0 8 8 8 8 Pumilio-family RNA binding repeat CPL PF08144.11 ETO30833.1 - 0.18 12.1 0.2 11 6.4 0.0 3.5 4 1 0 4 4 4 0 CPL (NUC119) domain Period_C PF12114.8 ETO30833.1 - 0.32 10.6 3.8 0.5 9.9 3.8 1.2 1 0 0 1 1 1 0 Period protein 2/3C-terminal region SSP160 PF06933.11 ETO30833.1 - 0.92 7.6 19.0 1.3 7.1 19.0 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 ETO30833.1 - 1.5 6.8 8.3 2.2 6.3 8.3 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Pkinase PF00069.25 ETO30835.1 - 2.2e-40 138.7 0.0 1.5e-38 132.7 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30835.1 - 1e-19 70.9 0.0 2.9e-19 69.4 0.0 1.6 1 1 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO30835.1 - 0.0021 17.5 0.0 0.0034 16.8 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_C PF00433.24 ETO30835.1 - 0.016 15.9 1.3 0.027 15.2 1.3 1.4 1 0 0 1 1 1 0 Protein kinase C terminal domain Mrr_cat_2 PF13156.6 ETO30836.1 - 0.036 14.0 5.8 2.4 8.0 3.4 2.2 2 0 0 2 2 2 0 Restriction endonuclease PH PF00169.29 ETO30836.1 - 0.21 12.1 7.5 0.13 12.8 2.7 2.1 1 1 1 2 2 2 0 PH domain SUZ PF12752.7 ETO30836.1 - 0.77 10.6 0.1 0.77 10.6 0.1 2.7 3 0 0 3 3 3 0 SUZ domain Myosin_TH1 PF06017.13 ETO30837.1 - 6.6e-18 65.1 3.0 9.2e-18 64.6 3.0 1.2 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 ETO30837.1 - 0.0023 17.6 0.3 0.0042 16.8 0.3 1.7 1 1 0 1 1 1 1 Inositol phosphatase Equine_IAV_S2 PF06502.11 ETO30838.1 - 0.055 13.5 0.5 0.3 11.2 0.1 2.1 2 0 0 2 2 2 0 Equine infectious anaemia virus S2 protein SPT_ssu-like PF11779.8 ETO30838.1 - 0.066 12.8 0.4 0.1 12.3 0.4 1.2 1 0 0 1 1 1 0 Small subunit of serine palmitoyltransferase-like SPATA3 PF15662.5 ETO30838.1 - 2.9 8.5 7.9 3.5 8.2 7.9 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 3 family PDZ_6 PF17820.1 ETO30839.1 - 3.7e-07 29.9 0.1 4.1e-05 23.4 0.0 3.0 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 ETO30839.1 - 0.00022 21.5 0.0 0.0024 18.2 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ_2 PF13180.6 ETO30839.1 - 0.0014 18.9 0.0 0.0029 17.9 0.0 1.5 1 0 0 1 1 1 1 PDZ domain SAM_1 PF00536.30 ETO30839.1 - 0.0056 17.1 0.2 0.023 15.1 0.0 2.0 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO30839.1 - 0.016 15.4 0.0 0.049 13.9 0.0 1.8 1 1 0 1 1 1 0 Ste50p, sterile alpha motif SAM_2 PF07647.17 ETO30839.1 - 0.017 15.2 0.0 0.035 14.2 0.0 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Ribosomal_S13_N PF08069.12 ETO30839.1 - 0.15 12.1 0.0 5.6 7.1 0.0 2.5 2 0 0 2 2 2 0 Ribosomal S13/S15 N-terminal domain Pro_isomerase PF00160.21 ETO30840.1 - 1.4e-12 48.2 0.0 4.7e-12 46.5 0.0 1.9 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD Kelch_6 PF13964.6 ETO30840.1 - 0.006 16.8 2.0 2.9 8.3 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO30840.1 - 0.0066 16.4 4.3 0.69 10.0 0.3 3.7 4 0 0 4 4 4 2 Kelch motif DUF5346 PF17281.2 ETO30840.1 - 0.028 14.4 3.2 0.069 13.2 3.2 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5346) Kelch_2 PF07646.15 ETO30840.1 - 0.035 14.1 0.3 12 6.1 0.0 3.3 3 0 0 3 3 3 0 Kelch motif BLOC1_2 PF10046.9 ETO30840.1 - 2.2 8.6 8.0 0.59 10.5 3.1 2.5 2 0 0 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF676 PF05057.14 ETO30841.1 - 2.3e-24 86.1 0.2 3.9e-23 82.1 0.2 2.2 1 1 0 1 1 1 1 Putative serine esterase (DUF676) Palm_thioest PF02089.15 ETO30841.1 - 0.00061 19.7 0.0 0.00099 19.0 0.0 1.5 1 0 0 1 1 1 1 Palmitoyl protein thioesterase DUF5560 PF17715.1 ETO30841.1 - 0.25 10.8 0.2 0.43 10.0 0.2 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5560) Citrate_synt PF00285.21 ETO30842.1 - 1.1e-53 182.7 0.0 2.9e-53 181.2 0.0 1.6 1 1 0 1 1 1 1 Citrate synthase, C-terminal domain SDH_sah PF01972.16 ETO30842.1 - 0.058 12.4 0.6 0.64 9.0 0.2 2.0 2 0 0 2 2 2 0 Serine dehydrogenase proteinase Citrate_synt PF00285.21 ETO30843.1 - 1.1e-37 130.0 0.1 1.4e-37 129.6 0.1 1.1 1 0 0 1 1 1 1 Citrate synthase, C-terminal domain DUF3906 PF13046.6 ETO30843.1 - 0.049 13.7 0.0 0.099 12.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) TMF_TATA_bd PF12325.8 ETO30844.1 - 0.74 10.1 18.7 0.36 11.1 6.0 3.1 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding EF-hand_7 PF13499.6 ETO30844.1 - 1.7 9.2 9.6 1.3 9.5 0.1 3.6 3 1 0 3 3 3 0 EF-hand domain pair LRR19-TM PF15176.6 ETO30844.1 - 3.7 7.6 7.1 0.3 11.1 0.4 2.7 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain PspB PF06667.12 ETO30844.1 - 9.7 6.3 7.2 3.4 7.8 0.1 3.6 2 1 1 3 3 3 0 Phage shock protein B Orf78 PF06024.12 ETO30844.1 - 9.7 6.6 15.1 3.9 7.8 0.7 3.8 4 0 0 4 4 4 0 Orf78 (ac78) Ribosomal_L28 PF00830.19 ETO30846.1 - 0.037 14.2 0.9 0.052 13.7 0.9 1.2 1 0 0 1 1 1 0 Ribosomal L28 family GAS PF13851.6 ETO30847.1 - 0.0001 21.8 54.8 0.023 14.1 27.3 2.2 1 1 1 2 2 2 2 Growth-arrest specific micro-tubule binding XhlA PF10779.9 ETO30847.1 - 0.0047 17.1 1.7 0.0047 17.1 1.7 4.6 3 2 0 4 4 4 1 Haemolysin XhlA Baculo_PEP_C PF04513.12 ETO30847.1 - 0.012 15.6 11.1 0.53 10.3 3.2 2.8 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus TMPIT PF07851.13 ETO30847.1 - 0.04 13.2 36.9 0.015 14.6 11.4 2.8 1 1 2 3 3 3 0 TMPIT-like protein IFT57 PF10498.9 ETO30847.1 - 0.051 12.5 36.6 1.2 8.0 16.4 2.4 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Laminin_II PF06009.12 ETO30847.1 - 0.1 12.6 27.0 0.028 14.4 8.3 3.8 1 1 3 4 4 4 0 Laminin Domain II DUF1664 PF07889.12 ETO30847.1 - 0.24 11.4 29.8 0.2 11.7 9.0 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 ETO30847.1 - 0.31 9.6 30.9 0.22 10.1 29.4 1.4 1 1 0 1 1 1 0 AAA domain ERM PF00769.19 ETO30847.1 - 0.35 10.7 57.3 0.18 11.6 27.1 2.0 1 1 1 2 2 2 0 Ezrin/radixin/moesin family PI_PP_I PF18363.1 ETO30847.1 - 0.53 10.5 10.5 1.4 9.2 0.6 3.3 1 1 2 3 3 3 0 Phosphoinositide phosphatase insertion domain TPR_MLP1_2 PF07926.12 ETO30847.1 - 0.59 10.2 53.8 0.39 10.8 22.7 3.8 1 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein Cep57_MT_bd PF06657.13 ETO30847.1 - 0.6 10.6 41.1 1.1 9.8 5.8 4.8 1 1 4 5 5 5 0 Centrosome microtubule-binding domain of Cep57 Phage_GP20 PF06810.11 ETO30847.1 - 0.76 9.6 42.3 0.071 12.9 15.0 3.8 1 1 2 3 3 3 0 Phage minor structural protein GP20 Prominin PF05478.11 ETO30847.1 - 0.85 7.5 29.7 0.045 11.7 16.4 2.0 1 1 1 2 2 2 0 Prominin CENP-Q PF13094.6 ETO30847.1 - 0.99 9.6 44.4 1.9 8.6 17.0 2.4 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF948 PF06103.11 ETO30847.1 - 1.3 9.3 17.3 0.051 13.8 2.2 3.7 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) Golgin_A5 PF09787.9 ETO30847.1 - 1.7 8.0 49.2 2.7 7.4 19.7 2.6 1 1 2 3 3 3 0 Golgin subfamily A member 5 TMF_TATA_bd PF12325.8 ETO30847.1 - 1.9 8.8 44.4 0.46 10.7 15.1 3.6 1 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Cep57_CLD_2 PF14197.6 ETO30847.1 - 1.9 8.6 39.8 0.14 12.3 10.8 5.8 1 1 1 3 3 3 0 Centrosome localisation domain of PPC89 DUF812 PF05667.11 ETO30847.1 - 2.4 6.9 50.8 0.39 9.5 30.0 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF812) FPP PF05911.11 ETO30847.1 - 2.5 6.2 49.7 0.24 9.6 24.4 2.0 1 1 1 2 2 2 0 Filament-like plant protein, long coiled-coil ADIP PF11559.8 ETO30847.1 - 2.8 8.0 44.5 0.5 10.4 16.2 3.2 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding KxDL PF10241.9 ETO30847.1 - 3.3 8.0 34.8 0.53 10.6 2.5 5.2 1 1 4 6 6 6 0 Uncharacterized conserved protein DUF3584 PF12128.8 ETO30847.1 - 4.6 4.6 46.5 4.9 4.5 22.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3584) BLOC1_2 PF10046.9 ETO30847.1 - 4.9 7.5 37.0 2.8 8.3 10.0 4.2 1 1 4 5 5 5 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 HSBP1 PF06825.12 ETO30847.1 - 5.6 6.9 23.1 1.5 8.8 1.1 4.8 4 1 1 5 5 5 0 Heat shock factor binding protein 1 EzrA PF06160.12 ETO30847.1 - 6.3 4.8 44.8 0.03 12.5 28.5 2.4 1 1 1 2 2 2 0 Septation ring formation regulator, EzrA Spc7 PF08317.11 ETO30847.1 - 6.4 5.6 51.0 8.4 5.2 6.7 3.2 1 1 1 2 2 2 0 Spc7 kinetochore protein Fez1 PF06818.15 ETO30847.1 - 7.4 7.0 47.0 11 6.5 21.9 2.4 1 1 1 2 2 2 0 Fez1 APG6_N PF17675.1 ETO30847.1 - 7.8 7.0 58.2 0.43 11.1 20.2 3.5 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF4515 PF14988.6 ETO30847.1 - 7.9 6.3 53.4 0.36 10.6 17.3 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4515) NPV_P10 PF05531.12 ETO30847.1 - 8.3 7.0 17.7 3.5 8.2 2.1 3.8 1 1 3 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3450 PF11932.8 ETO30847.1 - 8.6 5.6 40.3 0.19 11.0 15.0 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3450) Lebercilin PF15619.6 ETO30847.1 - 9.7 5.8 56.9 9.1 5.9 16.4 3.2 1 1 2 3 3 3 0 Ciliary protein causing Leber congenital amaurosis disease DUF4201 PF13870.6 ETO30847.1 - 9.7 5.9 52.1 5.6 6.7 19.4 3.5 1 1 2 3 3 3 0 Domain of unknown function (DUF4201) Kinesin PF00225.23 ETO30848.1 - 0.0055 15.7 0.0 0.016 14.2 0.0 1.6 1 1 0 1 1 1 1 Kinesin motor domain MFA1_2 PF17317.2 ETO30848.1 - 0.18 11.6 0.4 0.5 10.2 0.4 1.7 1 0 0 1 1 1 0 Mating hormone A-factor 1&2 DUF5340 PF17275.2 ETO30849.1 - 0.021 15.0 0.2 0.39 10.9 0.1 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5340) DUF3450 PF11932.8 ETO30849.1 - 0.051 12.9 2.0 0.1 11.9 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) TMCCDC2 PF15844.5 ETO30849.1 - 0.36 10.8 7.3 0.49 10.3 4.2 2.5 1 1 0 2 2 2 0 Transmembrane and coiled-coil domain-containing protein 2 eRF1_3 PF03465.15 ETO30849.1 - 0.37 11.3 2.0 31 5.1 0.1 3.0 2 1 0 2 2 2 0 eRF1 domain 3 PEPCK_GTP PF00821.18 ETO30850.1 - 1.5e-117 392.5 0.0 1.9e-117 392.1 0.0 1.1 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxykinase C-terminal P-loop domain PEPCK_N PF17297.2 ETO30850.1 - 6.5e-79 264.6 1.6 3.8e-43 147.6 0.1 2.9 2 1 0 2 2 2 2 Phosphoenolpyruvate carboxykinase N-terminal domain FliE PF02049.18 ETO30851.1 - 0.2 11.8 7.1 0.29 11.3 5.2 1.9 1 1 1 2 2 2 0 Flagellar hook-basal body complex protein FliE DUF1676 PF07898.13 ETO30851.1 - 0.38 10.8 5.0 0.43 10.6 5.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) Menin PF05053.13 ETO30851.1 - 1.3 7.3 12.0 1.4 7.2 12.0 1.1 1 0 0 1 1 1 0 Menin UTP15_C PF09384.10 ETO30852.1 - 1.3e-19 70.3 0.0 1.8e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 UTP15 C terminal RCC1 PF00415.18 ETO30853.1 - 1.3e-45 153.8 20.2 4.2e-09 36.9 0.1 8.1 8 1 0 8 8 8 7 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO30853.1 - 1.8e-30 104.1 28.8 1.9e-07 30.7 0.3 7.2 7 0 0 7 7 7 6 Regulator of chromosome condensation (RCC1) repeat TPR_12 PF13424.6 ETO30854.1 - 5.3e-09 36.2 2.2 9.3e-06 25.9 0.1 2.6 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30854.1 - 0.012 15.7 1.8 5.6 7.4 0.1 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30854.1 - 0.026 14.4 0.1 0.25 11.3 0.0 2.6 3 0 0 3 3 3 0 Tetratricopeptide repeat RSS_P20 PF11757.8 ETO30854.1 - 0.26 11.8 4.4 5.5 7.5 0.4 3.2 3 0 0 3 3 3 0 Suppressor of RNA silencing P21-like N-terminal domain TPR_1 PF00515.28 ETO30854.1 - 0.54 10.2 2.7 8.8 6.3 0.1 2.9 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5314 PF17241.2 ETO30854.1 - 0.6 9.7 6.0 0.26 10.9 0.1 2.5 3 0 0 3 3 3 0 Family of unknown function (DUF5314) TPR_2 PF07719.17 ETO30854.1 - 2 8.8 5.4 21 5.6 0.1 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat YEATS PF03366.16 ETO30855.1 - 2.3e-22 78.8 0.1 4.8e-22 77.7 0.1 1.6 1 0 0 1 1 1 1 YEATS family DUF936 PF06075.12 ETO30855.1 - 0.015 14.3 18.8 0.022 13.7 18.8 1.2 1 0 0 1 1 1 0 Plant protein of unknown function (DUF936) PhyH PF05721.13 ETO30856.1 - 0.0013 19.1 0.0 0.39 11.0 0.0 2.5 2 1 1 3 3 3 2 Phytanoyl-CoA dioxygenase (PhyH) Longin PF13774.6 ETO30857.1 - 9.9e-17 60.8 1.9 1.2e-16 60.5 0.6 1.9 2 0 0 2 2 2 1 Regulated-SNARE-like domain Synaptobrevin PF00957.21 ETO30857.1 - 6.3e-10 38.7 0.3 6.3e-10 38.7 0.3 2.3 2 0 0 2 2 2 1 Synaptobrevin PX PF00787.24 ETO30857.1 - 1.1e-07 31.8 0.0 3.2e-07 30.3 0.0 1.7 1 0 0 1 1 1 1 PX domain Vfa1 PF08432.10 ETO30857.1 - 0.023 15.0 17.9 0.14 12.5 17.9 2.1 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SPX PF03105.19 ETO30857.1 - 0.41 10.5 20.0 0.7 9.7 20.0 1.3 1 0 0 1 1 1 0 SPX domain Raftlin PF15250.6 ETO30857.1 - 0.46 9.2 11.6 0.78 8.4 11.6 1.3 1 0 0 1 1 1 0 Raftlin Flu_B_M2 PF04772.12 ETO30857.1 - 1.4 9.2 6.1 0.51 10.6 0.4 3.0 3 0 0 3 3 3 0 Influenza B matrix protein 2 (BM2) DUF4897 PF16238.5 ETO30857.1 - 1.6 8.6 6.7 0.068 13.0 0.7 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4897) Cytochrom_B562 PF07361.11 ETO30857.1 - 2.3 8.9 7.5 0.26 12.0 1.4 2.6 3 0 0 3 3 3 0 Cytochrome b562 Macoilin PF09726.9 ETO30857.1 - 8.6 4.8 18.4 14 4.1 18.4 1.2 1 0 0 1 1 1 0 Macoilin family DUF4381 PF14316.6 ETO30858.1 - 0.0071 16.6 0.5 0.013 15.7 0.5 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) DUF2207 PF09972.9 ETO30858.1 - 0.024 13.4 0.0 0.039 12.7 0.0 1.3 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Lipid_DES PF08557.10 ETO30858.1 - 0.052 13.1 0.0 0.098 12.2 0.0 1.4 1 0 0 1 1 1 0 Sphingolipid Delta4-desaturase (DES) XhlA PF10779.9 ETO30858.1 - 0.071 13.3 1.0 0.16 12.2 1.0 1.6 1 0 0 1 1 1 0 Haemolysin XhlA Orf78 PF06024.12 ETO30859.1 - 0.012 15.9 0.4 0.012 15.9 0.4 2.1 2 0 0 2 2 2 0 Orf78 (ac78) SDA1 PF05285.12 ETO30859.1 - 0.096 12.1 4.4 0.093 12.1 4.4 1.1 1 0 0 1 1 1 0 SDA1 BSP_II PF05432.11 ETO30859.1 - 0.39 10.4 12.3 0.49 10.0 12.3 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4637 PF15470.6 ETO30859.1 - 1.1 9.0 7.8 1.5 8.5 7.8 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Tropomyosin_1 PF12718.7 ETO30860.1 - 0.0092 16.1 13.3 0.013 15.7 2.2 2.2 2 0 0 2 2 2 1 Tropomyosin like DivIC PF04977.15 ETO30860.1 - 0.01 15.6 5.0 0.23 11.2 0.4 2.3 2 0 0 2 2 2 0 Septum formation initiator Csm1_N PF18504.1 ETO30860.1 - 0.031 14.6 15.3 0.058 13.7 3.2 2.8 2 1 1 3 3 3 0 Csm1 N-terminal domain TMF_DNA_bd PF12329.8 ETO30860.1 - 0.038 14.0 12.6 0.12 12.3 3.7 2.5 2 1 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Cnn_1N PF07989.11 ETO30860.1 - 0.038 14.1 1.1 0.038 14.1 1.1 2.6 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 CC2-LZ PF16516.5 ETO30860.1 - 0.061 13.7 8.5 1.1 9.7 0.8 2.4 2 0 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator LemA PF04011.12 ETO30860.1 - 0.15 11.9 2.2 0.29 11.0 0.6 1.9 1 1 0 2 2 2 0 LemA family NPV_P10 PF05531.12 ETO30860.1 - 0.24 11.9 4.8 3.4 8.2 0.1 2.7 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Nop25 PF09805.9 ETO30860.1 - 0.35 11.3 5.6 2.8 8.4 0.3 2.1 1 1 1 2 2 2 0 Nucleolar protein 12 (25kDa) TACC_C PF05010.14 ETO30860.1 - 0.39 10.5 13.0 0.087 12.6 3.2 2.0 1 1 1 2 2 2 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal ABC_tran_CTD PF16326.5 ETO30860.1 - 0.5 10.7 9.3 0.29 11.4 1.0 2.5 2 1 1 3 3 3 0 ABC transporter C-terminal domain DUF2408 PF10303.9 ETO30860.1 - 1.1 9.9 7.6 0.68 10.5 0.5 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2408) Exonuc_VII_S PF02609.16 ETO30860.1 - 1.3 9.1 10.0 0.59 10.2 2.4 2.5 2 0 0 2 2 2 0 Exonuclease VII small subunit KLRAQ PF10205.9 ETO30860.1 - 1.8 8.8 8.5 0.57 10.5 0.8 2.3 1 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein SlyX PF04102.12 ETO30860.1 - 2.1 9.0 7.4 7.7 7.2 0.5 2.7 2 1 0 2 2 2 0 SlyX JIP_LZII PF16471.5 ETO30860.1 - 3.2 8.0 10.5 1.7 8.9 1.0 2.8 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II bZIP_1 PF00170.21 ETO30860.1 - 6.5 6.9 11.3 21 5.3 5.4 2.3 2 0 0 2 2 2 0 bZIP transcription factor ATP-synt_G PF04718.15 ETO30862.1 - 0.005 17.6 0.0 0.0097 16.7 0.0 1.5 1 0 0 1 1 1 1 Mitochondrial ATP synthase g subunit WD40 PF00400.32 ETO30863.1 - 3.8e-22 78.2 4.5 3e-05 24.7 0.1 5.4 6 1 0 6 6 6 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO30863.1 - 4.8e-07 28.8 0.7 0.12 11.0 0.0 3.9 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO30863.1 - 5.5e-07 29.8 0.3 0.29 11.5 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C48 PF02902.19 ETO30865.1 - 1.3e-27 97.1 8.1 1.3e-27 97.1 8.1 2.2 2 1 1 3 3 3 1 Ulp1 protease family, C-terminal catalytic domain SecA_SW PF07516.13 ETO30865.1 - 0.0052 16.9 3.9 0.0082 16.2 3.9 1.3 1 0 0 1 1 1 1 SecA Wing and Scaffold domain Ribosomal_S6e PF01092.19 ETO30865.1 - 0.71 9.9 5.1 1.1 9.3 3.7 2.0 2 1 1 3 3 3 0 Ribosomal protein S6e Kelch_1 PF01344.25 ETO30866.1 - 1.6e-06 27.6 4.7 0.00013 21.5 0.3 4.9 5 0 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO30866.1 - 1.9e-06 27.7 2.4 0.13 12.3 0.2 4.8 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO30866.1 - 2.5e-06 27.6 7.6 0.17 12.2 0.2 7.0 7 0 0 7 7 7 1 Kelch motif Kelch_4 PF13418.6 ETO30866.1 - 1.3e-05 25.1 3.7 0.001 19.0 0.0 4.4 5 0 0 5 5 5 1 Galactose oxidase, central domain BBS2_N PF14781.6 ETO30866.1 - 0.083 12.8 0.1 0.42 10.5 0.1 2.2 1 0 0 1 1 1 0 Ciliary BBSome complex subunit 2, N-terminal Kelch_3 PF13415.6 ETO30866.1 - 0.23 11.8 5.0 3.4 8.1 0.0 4.9 5 0 0 5 5 5 0 Galactose oxidase, central domain PRIMA1 PF16101.5 ETO30866.1 - 2.2 8.3 6.3 0.87 9.6 3.0 2.0 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 UCH PF00443.29 ETO30867.1 - 9.1e-37 126.9 17.2 9.1e-37 126.9 17.2 3.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO30867.1 - 2.5e-17 63.5 31.5 2.4e-16 60.2 7.6 3.6 2 2 0 2 2 2 2 Ubiquitin carboxyl-terminal hydrolase Adeno_PV PF03910.13 ETO30867.1 - 1.9 7.1 5.3 27 3.3 0.0 2.6 2 0 0 2 2 2 0 Adenovirus minor core protein PV DUF3439 PF11921.8 ETO30868.1 - 0.07 13.1 3.5 0.13 12.2 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO30868.1 - 1.1 7.4 7.6 1.5 6.9 7.6 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Exo_endo_phos PF03372.23 ETO30869.1 - 1.7e-07 31.0 0.0 1.6e-06 27.9 0.0 2.5 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family TTL PF03133.15 ETO30870.1 - 3.4e-25 88.8 5.4 9.8e-24 84.0 1.6 3.2 2 2 1 3 3 3 1 Tubulin-tyrosine ligase family DUF4974 PF16344.5 ETO30870.1 - 0.0082 16.1 0.2 0.02 14.9 0.2 1.6 1 0 0 1 1 1 1 Domain of unknown function (DUF4974) ATPgrasp_YheCD PF14398.6 ETO30870.1 - 0.12 11.7 3.4 0.2 10.8 0.0 2.8 3 1 0 3 3 3 0 YheC/D like ATP-grasp Cry1Ac_D5 PF17997.1 ETO30870.1 - 0.14 12.0 0.2 0.28 11.0 0.2 1.4 1 0 0 1 1 1 0 Insecticidal delta-endotoxin CryIA(c) domain 5 Mito_carr PF00153.27 ETO30871.1 - 5.1e-34 116.1 3.6 1.9e-15 56.6 0.1 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3176 PF11374.8 ETO30871.1 - 0.023 14.9 0.0 9.7 6.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3176) Glyco_hydro_31 PF01055.26 ETO30872.1 - 3.7e-08 33.0 0.0 6.9e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 31 DUF4968 PF16338.5 ETO30872.1 - 5e-07 30.0 0.0 9.1e-07 29.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4968) Acid_phosphat_B PF03767.14 ETO30872.1 - 0.029 13.9 0.1 0.057 13.0 0.1 1.4 1 0 0 1 1 1 0 HAD superfamily, subfamily IIIB (Acid phosphatase) Cyclin_N PF00134.23 ETO30873.1 - 4.4e-10 39.4 8.2 1.5e-08 34.4 1.3 3.0 3 0 0 3 3 3 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO30873.1 - 3.1e-09 37.0 2.2 9.3e-09 35.4 0.0 2.8 3 0 0 3 3 3 1 Cyclin, C-terminal domain MutS_V PF00488.21 ETO30875.1 - 4.5e-28 98.6 0.0 5.3e-28 98.3 0.0 1.0 1 0 0 1 1 1 1 MutS domain V MutS_V PF00488.21 ETO30876.1 - 3.5e-29 102.2 0.6 5.4e-29 101.6 0.6 1.2 1 0 0 1 1 1 1 MutS domain V AAA_29 PF13555.6 ETO30876.1 - 0.017 14.9 0.0 0.03 14.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO30876.1 - 0.037 14.5 0.0 0.28 11.7 0.0 2.0 2 0 0 2 2 2 0 AAA domain MutS_III PF05192.18 ETO30876.1 - 0.045 14.0 0.0 0.064 13.5 0.0 1.3 1 0 0 1 1 1 0 MutS domain III DUF5473 PF17567.2 ETO30877.1 - 0.045 14.0 0.0 0.11 12.8 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5473) DUF3800 PF12686.7 ETO30879.1 - 0.028 15.0 0.5 3 8.5 0.5 3.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) SHE3 PF17078.5 ETO30879.1 - 2.5 7.7 58.1 0.81 9.4 6.9 3.4 1 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 FlaC_arch PF05377.11 ETO30879.1 - 3 8.3 30.7 6 7.3 1.1 6.4 4 3 2 6 6 6 0 Flagella accessory protein C (FlaC) TPR_MLP1_2 PF07926.12 ETO30880.1 - 0.0023 18.0 17.0 0.0023 18.0 17.0 5.6 3 2 2 5 5 5 1 TPR/MLP1/MLP2-like protein DUF4201 PF13870.6 ETO30880.1 - 0.0025 17.6 11.8 0.0025 17.6 11.8 4.6 4 1 1 5 5 5 1 Domain of unknown function (DUF4201) GAS PF13851.6 ETO30880.1 - 0.0031 16.9 26.5 0.0031 16.9 26.5 5.1 2 2 3 5 5 5 3 Growth-arrest specific micro-tubule binding DivIC PF04977.15 ETO30880.1 - 0.18 11.6 0.1 0.18 11.6 0.1 8.2 5 2 3 8 8 8 0 Septum formation initiator DUF3800 PF12686.7 ETO30880.1 - 1.2 9.8 5.0 2.7e+02 2.2 5.0 3.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) WD40 PF00400.32 ETO30881.1 - 7.5e-130 419.0 49.9 7.5e-10 39.2 1.3 15.1 14 1 1 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30881.1 - 2.6e-30 104.6 11.8 0.0016 18.7 0.0 12.2 2 2 11 13 13 13 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30881.1 - 1e-19 70.7 0.1 0.43 9.5 0.0 11.0 2 2 9 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO30881.1 - 2.1e-13 50.3 1.1 1.2 8.4 0.0 7.3 4 3 3 8 8 8 5 WD40-like domain Nup160 PF11715.8 ETO30881.1 - 4e-09 35.7 19.8 0.092 11.4 0.0 10.9 3 2 7 11 11 11 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO30881.1 - 6.9e-08 32.2 22.8 21 5.2 0.0 11.6 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO30881.1 - 1.5e-06 27.7 9.4 0.18 11.1 0.0 7.2 2 2 3 7 7 7 2 Neuroblastoma-amplified sequence, N terminal Pentapeptide PF00805.22 ETO30881.1 - 1.8e-05 24.3 3.3 5e-05 22.9 2.9 1.9 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO30881.1 - 0.00029 20.9 0.1 0.00092 19.3 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO30881.1 - 0.0017 17.0 8.3 2.1 6.8 0.1 5.2 1 1 3 6 6 6 2 Cytochrome D1 heme domain DUF1652 PF07865.11 ETO30881.1 - 0.0071 16.1 0.1 14 5.6 0.0 5.6 6 1 1 7 7 7 0 Protein of unknown function (DUF1652) Pentapeptide_3 PF13576.6 ETO30881.1 - 0.014 15.5 1.6 0.064 13.4 1.6 2.1 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) Mid2 PF04478.12 ETO30881.1 - 0.054 13.3 0.2 15 5.4 0.0 4.6 6 0 0 6 6 6 0 Mid2 like cell wall stress sensor DNA_alkylation PF08713.11 ETO30882.1 - 1.2e-32 113.3 0.6 3.8e-32 111.8 0.6 1.7 1 1 0 1 1 1 1 DNA alkylation repair enzyme DUF4816 PF16086.5 ETO30882.1 - 0.72 9.8 4.3 13 5.8 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4816) E2R135 PF11570.8 ETO30883.1 - 0.0041 17.4 1.0 0.005 17.1 1.0 1.3 1 1 0 1 1 1 1 Coiled-coil receptor-binding R-domain of colicin E2 Pox_A_type_inc PF04508.12 ETO30883.1 - 0.008 16.0 10.5 0.011 15.5 1.2 3.8 2 1 2 4 4 4 1 Viral A-type inclusion protein repeat Spc7 PF08317.11 ETO30883.1 - 0.01 14.7 11.5 0.013 14.5 11.5 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein Nup88 PF10168.9 ETO30883.1 - 0.011 13.6 7.8 0.013 13.3 7.8 1.0 1 0 0 1 1 1 0 Nuclear pore component PspA_IM30 PF04012.12 ETO30883.1 - 0.014 15.0 9.2 0.017 14.7 9.2 1.1 1 0 0 1 1 1 0 PspA/IM30 family FliS PF02561.14 ETO30883.1 - 0.015 15.6 3.3 0.018 15.3 3.3 1.2 1 0 0 1 1 1 0 Flagellar protein FliS SF-assemblin PF06705.11 ETO30883.1 - 0.019 14.3 7.9 0.026 13.9 7.9 1.1 1 0 0 1 1 1 0 SF-assemblin/beta giardin CALCOCO1 PF07888.11 ETO30883.1 - 0.022 13.6 12.3 0.027 13.3 12.3 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like DUF1852 PF08908.11 ETO30883.1 - 0.031 13.3 0.0 0.034 13.1 0.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF1852) Golgin_A5 PF09787.9 ETO30883.1 - 0.036 13.5 12.2 0.052 13.0 12.2 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 CENP-F_leu_zip PF10473.9 ETO30883.1 - 0.042 13.9 15.4 1.3 9.0 15.4 2.1 1 1 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 T3SSipB PF16535.5 ETO30883.1 - 0.045 14.2 2.6 1.4 9.3 0.4 2.0 1 1 1 2 2 2 0 Type III cell invasion protein SipB Ax_dynein_light PF10211.9 ETO30883.1 - 0.066 13.2 12.0 0.29 11.0 6.2 2.1 1 1 1 2 2 2 0 Axonemal dynein light chain TRAF_BIRC3_bd PF16673.5 ETO30883.1 - 0.073 12.9 1.0 0.073 12.9 1.0 2.3 2 1 1 3 3 2 0 TNF receptor-associated factor BIRC3 binding domain Phage_GP20 PF06810.11 ETO30883.1 - 0.095 12.5 7.4 0.095 12.5 3.1 1.9 1 1 1 2 2 2 0 Phage minor structural protein GP20 BST2 PF16716.5 ETO30883.1 - 0.11 13.1 11.5 0.16 12.6 6.8 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 Spc24 PF08286.11 ETO30883.1 - 0.13 12.5 9.8 0.91 9.8 5.2 2.0 1 1 0 2 2 2 0 Spc24 subunit of Ndc80 SlyX PF04102.12 ETO30883.1 - 0.16 12.6 11.8 1.2 9.8 1.0 2.1 1 1 0 2 2 2 0 SlyX DUF2730 PF10805.8 ETO30883.1 - 0.2 11.8 2.5 9.4 6.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) AAA_13 PF13166.6 ETO30883.1 - 0.21 10.2 7.5 0.5 8.9 7.5 1.6 1 1 0 1 1 1 0 AAA domain TipAS PF07739.13 ETO30883.1 - 0.25 11.9 3.3 0.48 11.0 3.3 1.6 1 1 0 1 1 1 0 TipAS antibiotic-recognition domain TPR_MLP1_2 PF07926.12 ETO30883.1 - 0.25 11.4 14.8 3.1 7.9 5.4 2.2 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF1664 PF07889.12 ETO30883.1 - 0.3 11.1 5.2 3.7 7.6 0.5 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) ApoO PF09769.9 ETO30883.1 - 0.35 10.8 1.6 0.73 9.8 0.5 1.8 1 1 1 2 2 2 0 Apolipoprotein O LIN52 PF10044.9 ETO30883.1 - 0.38 11.5 3.4 5.4 7.8 3.1 2.3 1 1 0 1 1 1 0 Retinal tissue protein FapA PF03961.13 ETO30883.1 - 0.4 9.2 9.2 0.49 8.9 9.2 1.0 1 0 0 1 1 1 0 Flagellar Assembly Protein A AAA_32 PF13654.6 ETO30883.1 - 0.44 9.3 8.3 0.52 9.0 8.3 1.1 1 0 0 1 1 1 0 AAA domain XLF PF09302.11 ETO30883.1 - 0.47 10.6 5.3 2.3 8.4 5.3 1.8 1 1 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component Ribonuc_2-5A PF06479.12 ETO30883.1 - 0.48 10.6 5.1 0.99 9.6 5.1 1.6 1 1 0 1 1 1 0 Ribonuclease 2-5A Phage_GPO PF05929.11 ETO30883.1 - 0.5 9.9 5.0 0.6 9.7 5.0 1.1 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase DUF724 PF05266.14 ETO30883.1 - 0.52 10.1 12.9 2.4 8.0 0.2 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF724) JIP_LZII PF16471.5 ETO30883.1 - 0.54 10.5 10.6 0.097 12.9 2.1 2.6 1 1 2 3 3 3 0 JNK-interacting protein leucine zipper II Exonuc_VII_L PF02601.15 ETO30883.1 - 0.72 9.4 8.2 0.77 9.3 8.2 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 ETO30883.1 - 0.76 9.1 6.8 1 8.6 6.8 1.3 1 0 0 1 1 1 0 FAM76 protein Cauli_AT PF03233.13 ETO30883.1 - 0.8 9.6 4.6 0.54 10.2 2.1 1.7 1 1 1 2 2 2 0 Aphid transmission protein Atg14 PF10186.9 ETO30883.1 - 0.82 8.7 10.6 1.1 8.2 10.6 1.3 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GlutR_dimer PF00745.20 ETO30883.1 - 0.85 10.1 8.0 1.4 9.4 7.9 1.5 1 1 0 1 1 1 0 Glutamyl-tRNAGlu reductase, dimerisation domain BRE1 PF08647.11 ETO30883.1 - 0.92 9.6 13.0 9 6.4 13.0 2.0 1 1 0 1 1 1 0 BRE1 E3 ubiquitin ligase Bcr-Abl_Oligo PF09036.10 ETO30883.1 - 1.1 9.3 5.0 1.2 9.2 2.4 2.4 1 1 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain GrpE PF01025.19 ETO30883.1 - 1.1 8.8 9.7 2.2 7.9 9.3 1.6 1 1 1 2 2 2 0 GrpE betaPIX_CC PF16523.5 ETO30883.1 - 1.1 9.1 8.8 0.44 10.4 4.9 2.0 1 1 0 2 2 2 0 betaPIX coiled coil TMPIT PF07851.13 ETO30883.1 - 1.2 8.3 5.7 1.8 7.7 5.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein DUF2203 PF09969.9 ETO30883.1 - 1.3 9.8 5.5 1.3 9.7 4.5 1.5 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) FlxA PF14282.6 ETO30883.1 - 1.4 9.0 9.6 4.1 7.5 0.9 2.1 1 1 1 2 2 2 0 FlxA-like protein Jnk-SapK_ap_N PF09744.9 ETO30883.1 - 1.4 9.1 16.1 3.9 7.7 5.5 2.0 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 Fib_alpha PF08702.10 ETO30883.1 - 1.8 8.7 6.7 2.8 8.1 6.7 1.3 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family TMF_DNA_bd PF12329.8 ETO30883.1 - 1.9 8.5 14.6 1.8 8.6 0.8 2.3 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding Asp-B-Hydro_N PF05279.11 ETO30883.1 - 2.4 8.2 7.2 2.7 8.0 7.2 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region DUF2968 PF11180.8 ETO30883.1 - 3.4 7.3 11.0 3.7 7.2 0.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2968) V_ATPase_I PF01496.19 ETO30883.1 - 3.6 5.4 6.4 3.8 5.3 6.4 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DivIC PF04977.15 ETO30883.1 - 3.7 7.4 10.2 4.8 7.0 2.9 2.4 1 1 1 2 2 2 0 Septum formation initiator OmpH PF03938.14 ETO30883.1 - 3.8 7.9 10.1 7.2 7.0 10.1 1.5 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) CENP-Q PF13094.6 ETO30883.1 - 4.1 7.6 19.5 4 7.6 10.4 2.0 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit Prefoldin_2 PF01920.20 ETO30883.1 - 4.2 7.4 12.2 9.7 6.2 4.5 2.3 1 1 0 2 2 2 0 Prefoldin subunit DUF4094 PF13334.6 ETO30883.1 - 4.5 7.7 6.8 5.8 7.4 1.9 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4094) DUF4407 PF14362.6 ETO30883.1 - 4.9 6.4 8.1 16 4.7 8.1 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4404 PF14357.6 ETO30883.1 - 5.4 7.7 11.4 0.68 10.6 5.7 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4404) Fzo_mitofusin PF04799.13 ETO30883.1 - 6.4 6.3 8.6 7.1 6.2 2.7 2.1 1 1 1 2 2 2 0 fzo-like conserved region YlqD PF11068.8 ETO30883.1 - 7.3 7.0 11.1 53 4.2 11.1 1.9 1 1 0 1 1 1 0 YlqD protein TPR_12 PF13424.6 ETO30884.1 - 8.5e-93 304.7 18.6 2.4e-20 72.6 0.1 5.1 2 1 5 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO30884.1 - 2.8e-57 189.1 0.3 1.1e-08 34.6 0.0 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO30884.1 - 2.7e-53 175.7 44.0 6.7e-11 41.5 1.6 7.1 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO30884.1 - 3.1e-39 130.1 7.6 1.4e-06 27.9 0.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO30884.1 - 3.6e-39 129.7 40.7 4.5e-09 35.8 0.7 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO30884.1 - 8.5e-37 122.3 29.1 1.1e-07 31.4 0.3 7.1 7 0 0 7 7 7 6 Tetratricopeptide repeat SNAP PF14938.6 ETO30884.1 - 1.2e-17 64.3 5.9 1.2e-09 38.0 0.3 3.2 2 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO30884.1 - 1.6e-17 62.5 23.8 0.00092 19.4 0.0 7.5 7 2 0 7 7 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO30884.1 - 9.9e-13 47.8 6.8 0.39 11.5 0.0 6.6 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO30884.1 - 2.5e-12 47.2 0.0 0.011 16.3 0.0 5.8 4 2 2 6 6 6 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO30884.1 - 2.7e-12 46.1 47.6 0.00085 19.0 1.3 10.6 7 6 6 13 13 13 5 TPR repeat TPR_14 PF13428.6 ETO30884.1 - 1.8e-09 37.6 0.0 5.2 8.2 0.0 6.3 6 1 1 7 7 6 1 Tetratricopeptide repeat MIT PF04212.18 ETO30884.1 - 3.5e-09 36.6 19.8 0.056 13.5 0.3 6.6 7 0 0 7 7 7 3 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO30884.1 - 3.1e-08 33.6 15.5 0.5 10.1 0.0 5.8 5 1 1 6 6 6 4 Domain of unknown function (DUF5113) PPR PF01535.20 ETO30884.1 - 5.4e-07 29.4 5.6 1.5 9.3 0.0 6.0 6 0 0 6 6 6 1 PPR repeat SHNi-TPR PF10516.9 ETO30884.1 - 4.4e-06 26.0 10.8 3.4 7.2 0.1 6.9 7 0 0 7 7 7 1 SHNi-TPR ANAPC3 PF12895.7 ETO30884.1 - 8.2e-06 26.0 13.0 0.05 13.8 0.8 4.3 2 1 3 5 5 5 4 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO30884.1 - 4.5e-05 23.9 1.7 0.63 10.6 0.0 4.7 4 1 1 5 5 5 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO30884.1 - 0.00057 19.7 14.1 3.1 7.5 1.2 4.0 1 1 2 3 3 3 2 Uncharacterized protein conserved in bacteria (DUF2225) DUF627 PF04781.12 ETO30884.1 - 0.0012 18.9 4.3 1.6 8.8 0.1 4.0 1 1 4 5 5 5 1 Protein of unknown function (DUF627) TPR_3 PF07720.12 ETO30884.1 - 0.0041 17.1 17.7 0.2 11.7 0.1 6.0 6 0 0 6 6 6 1 Tetratricopeptide repeat TEX29 PF15839.5 ETO30884.1 - 0.0041 17.7 0.0 1e+02 3.6 0.0 5.1 3 2 2 5 5 5 0 Testis-expressed sequence 29 protein Toxin_13 PF07822.11 ETO30884.1 - 0.0044 17.1 11.9 12 6.1 0.2 5.0 5 0 0 5 5 5 0 Neurotoxin B-IV-like protein RPN7 PF10602.9 ETO30884.1 - 0.0059 16.3 11.5 0.018 14.8 3.9 3.6 1 1 2 4 4 4 1 26S proteasome subunit RPN7 Tat PF00539.18 ETO30884.1 - 0.012 15.8 0.0 11 6.2 0.0 3.7 5 0 0 5 5 4 0 Transactivating regulatory protein (Tat) TPR_MalT PF17874.1 ETO30884.1 - 0.053 12.9 0.0 0.29 10.5 0.0 2.0 2 1 0 2 2 2 0 MalT-like TPR region HTH_Bact PF18768.1 ETO30884.1 - 0.067 12.8 7.5 25 4.6 0.0 5.7 6 0 0 6 6 6 0 Helix-turn-helix bacterial domain DUF386 PF04074.12 ETO30884.1 - 0.074 13.0 4.4 8.8 6.2 0.0 3.3 1 1 2 3 3 3 0 YhcH/YjgK/YiaL DUF520 PF04461.13 ETO30884.1 - 0.15 12.1 2.5 0.41 10.7 0.2 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF520) Cytochrom_CIII PF02085.16 ETO30884.1 - 0.33 11.3 2.5 0.92 9.9 0.4 2.5 2 1 0 3 3 2 0 Class III cytochrome C family SLT PF01464.20 ETO30884.1 - 0.62 9.7 3.2 3.5 7.3 0.1 2.6 2 0 0 2 2 2 0 Transglycosylase SLT domain NSF PF02071.20 ETO30884.1 - 1 10.4 20.8 30 6.0 0.2 7.0 7 0 0 7 7 6 0 Aromatic-di-Alanine (AdAR) repeat ATP-synt_E_2 PF08112.11 ETO30884.1 - 7.3 7.0 17.7 49 4.3 0.0 6.5 7 0 0 7 7 7 0 ATP synthase epsilon subunit Shisa PF13908.6 ETO30885.1 - 6.7e-08 33.0 0.1 6.7e-08 33.0 0.1 1.9 2 0 0 2 2 2 1 Wnt and FGF inhibitory regulator DUF2207 PF09972.9 ETO30885.1 - 0.035 12.9 0.2 0.28 9.9 0.0 2.0 2 0 0 2 2 2 0 Predicted membrane protein (DUF2207) TMEM52 PF14979.6 ETO30885.1 - 0.13 12.2 5.1 0.29 11.0 5.1 1.5 1 0 0 1 1 1 0 Transmembrane 52 WBP-1 PF11669.8 ETO30885.1 - 0.14 12.8 4.7 0.54 10.9 4.4 2.3 1 1 0 1 1 1 0 WW domain-binding protein 1 DUF4366 PF14283.6 ETO30885.1 - 0.19 11.8 10.3 0.56 10.3 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4366) DUF4407 PF14362.6 ETO30885.1 - 0.32 10.3 5.8 5.4 6.3 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Mucin PF01456.17 ETO30885.1 - 1.7 8.6 6.1 0.28 11.2 2.3 1.6 2 0 0 2 2 2 0 Mucin-like glycoprotein ETRAMP PF09716.10 ETO30885.1 - 1.9 8.6 11.3 0.4 10.8 5.2 2.8 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) EF-hand_1 PF00036.32 ETO30886.1 - 8.6e-28 93.8 12.9 3.8e-07 29.2 0.6 4.3 4 0 0 4 4 4 4 EF hand EF-hand_5 PF13202.6 ETO30886.1 - 5.2e-25 85.8 8.3 4e-06 26.1 0.1 4.3 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO30886.1 - 1.2e-22 77.8 11.2 5.2e-06 26.0 0.3 4.2 4 0 0 4 4 4 4 EF-hand domain EF-hand_7 PF13499.6 ETO30886.1 - 3.6e-22 78.6 6.7 1.2e-10 41.7 0.2 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO30886.1 - 9e-15 54.3 6.3 4.5e-05 23.2 0.4 4.3 4 0 0 4 4 4 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO30886.1 - 6.4e-11 42.6 0.3 0.00035 20.9 0.0 2.2 1 1 1 2 2 2 2 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_9 PF14658.6 ETO30886.1 - 0.017 15.4 2.7 18 5.7 0.3 3.7 3 1 0 3 3 3 0 EF-hand domain OST-HTH PF12872.7 ETO30886.1 - 0.027 14.3 0.0 3.3 7.6 0.0 2.3 2 0 0 2 2 2 0 OST-HTH/LOTUS domain EF-hand_11 PF08976.11 ETO30886.1 - 0.058 14.3 0.3 2.3 9.1 0.0 2.1 1 1 1 2 2 2 0 EF-hand domain Dockerin_1 PF00404.18 ETO30886.1 - 0.092 13.0 3.2 5.5 7.3 0.1 3.2 2 1 2 4 4 4 0 Dockerin type I domain EF-hand_10 PF14788.6 ETO30886.1 - 0.13 12.1 7.1 6.2 6.8 0.0 4.1 4 1 1 5 5 5 0 EF hand EF-hand_4 PF12763.7 ETO30886.1 - 0.28 11.2 6.2 0.64 10.0 0.1 3.1 1 1 3 4 4 4 0 Cytoskeletal-regulatory complex EF hand Tim54 PF11711.8 ETO30887.1 - 1.2 7.8 6.4 0.22 10.3 2.6 1.6 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 CLN3 PF02487.17 ETO30887.1 - 1.4 7.9 3.9 0.29 10.1 0.7 1.4 2 0 0 2 2 2 0 CLN3 protein Striatin PF08232.12 ETO30887.1 - 7.5 7.1 8.5 2.4 8.8 3.8 2.0 2 0 0 2 2 2 0 Striatin family AAA_9 PF12781.7 ETO30888.1 - 8.5e-65 217.9 0.9 3.1e-64 216.1 0.7 2.0 2 0 0 2 2 2 1 ATP-binding dynein motor region Dynein_heavy PF03028.15 ETO30888.1 - 1.7e-31 108.8 0.4 1.8e-30 105.4 0.0 2.9 3 0 0 3 3 3 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 ETO30888.1 - 2.2e-27 95.9 0.1 4.9e-27 94.7 0.1 1.6 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain MAT1 PF06391.13 ETO30888.1 - 0.27 11.0 4.0 0.56 10.0 4.0 1.5 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 PT PF04886.12 ETO30889.1 - 2e-82 270.4 541.2 7e-05 22.3 16.8 24.0 2 1 13 15 15 15 10 PT repeat TSP_1 PF00090.19 ETO30889.1 - 0.00034 20.7 9.6 0.00074 19.7 9.6 1.6 1 0 0 1 1 1 1 Thrombospondin type 1 domain IMUP PF15761.5 ETO30889.1 - 0.28 11.9 13.6 1.4 9.6 6.0 2.5 2 0 0 2 2 2 0 Immortalisation up-regulated protein Pkinase PF00069.25 ETO30890.1 - 7.6e-24 84.5 4.4 2.5e-23 82.8 4.4 1.8 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30890.1 - 2.3e-07 30.4 0.1 9.2e-07 28.4 0.1 1.9 2 0 0 2 2 2 1 Protein tyrosine kinase APH PF01636.23 ETO30890.1 - 0.002 18.1 0.5 0.42 10.5 0.0 2.2 1 1 1 2 2 2 2 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO30890.1 - 0.003 16.4 1.9 0.0082 15.0 0.2 2.0 2 0 0 2 2 2 1 Fungal protein kinase Choline_kinase PF01633.20 ETO30890.1 - 0.016 14.8 3.5 0.025 14.2 2.1 1.8 1 1 0 2 2 2 0 Choline/ethanolamine kinase EELM2 PF15863.5 ETO30891.1 - 0.012 15.7 0.8 0.018 15.1 0.8 1.3 1 0 0 1 1 1 0 Extended EGL-27 and MTA1 homology domain ASF1_hist_chap PF04729.13 ETO30892.1 - 1.6e-63 213.2 0.2 1.9e-63 213.0 0.2 1.1 1 0 0 1 1 1 1 ASF1 like histone chaperone WD40 PF00400.32 ETO30893.1 - 1.2e-41 139.9 33.5 5e-07 30.3 2.4 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30893.1 - 1.2e-10 41.5 0.5 0.035 14.4 0.0 5.0 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO30893.1 - 2.2e-08 33.2 8.8 0.098 11.3 0.1 5.9 2 2 2 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO30893.1 - 8e-06 25.4 5.2 0.13 11.5 0.1 5.2 4 1 2 6 6 6 2 WD40-like domain Nucleoporin_N PF08801.11 ETO30893.1 - 5.9 5.5 8.8 5.5 5.6 4.1 3.2 2 2 0 2 2 2 0 Nup133 N terminal like CBM-like PF14683.6 ETO30894.1 - 0.068 13.1 0.1 0.19 11.6 0.1 1.9 1 0 0 1 1 1 0 Polysaccharide lyase family 4, domain III zf-FCS PF06467.14 ETO30895.1 - 0.029 14.3 0.6 12 5.9 0.1 3.1 3 0 0 3 3 3 0 MYM-type Zinc finger with FCS sequence motif OST-HTH PF12872.7 ETO30895.1 - 0.12 12.2 0.0 24 4.8 0.0 2.8 3 0 0 3 3 3 0 OST-HTH/LOTUS domain OST-HTH PF12872.7 ETO30896.1 - 6.6e-06 25.9 1.5 1.2 9.0 0.0 5.5 6 0 0 6 6 6 2 OST-HTH/LOTUS domain CCDC168_N PF15804.5 ETO30896.1 - 0.0016 18.3 0.1 0.0048 16.8 0.1 1.7 1 0 0 1 1 1 1 Coiled-coil domain-containing protein 168 DUF3369 PF11849.8 ETO30896.1 - 0.02 15.1 0.3 0.071 13.3 0.3 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3369) Gemini_AC4_5_2 PF08464.10 ETO30896.1 - 0.062 13.2 0.6 0.22 11.5 0.6 1.9 1 0 0 1 1 1 0 Geminivirus AC4/5 conserved region Aa_trans PF01490.18 ETO30897.1 - 3.6e-14 52.3 3.7 3.6e-14 52.3 3.7 1.6 1 1 1 2 2 2 1 Transmembrane amino acid transporter protein Srg PF02118.21 ETO30899.1 - 0.049 13.3 0.1 0.063 12.9 0.1 1.1 1 0 0 1 1 1 0 Srg family chemoreceptor WD40 PF00400.32 ETO30900.1 - 1.2e-64 212.6 28.6 1.1e-09 38.7 0.1 14.4 14 1 0 14 14 14 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30900.1 - 6e-27 93.8 5.4 0.059 13.7 0.1 11.6 4 3 8 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO30900.1 - 2.2e-11 43.9 0.0 4.4e-11 43.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO30900.1 - 3.7e-08 32.9 1.0 7e-08 32.0 1.0 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Nup160 PF11715.8 ETO30900.1 - 2.4e-07 29.8 7.9 0.62 8.6 0.0 7.2 4 2 3 8 8 8 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO30900.1 - 5.3e-07 29.4 16.7 0.46 10.5 0.0 8.4 9 0 0 9 9 8 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO30900.1 - 0.00013 20.8 0.1 5.2 5.7 0.0 5.7 5 2 1 7 7 7 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region AAA_22 PF13401.6 ETO30900.1 - 0.00021 21.6 0.1 0.00096 19.4 0.1 2.1 1 1 0 1 1 1 1 AAA domain Pentapeptide_4 PF13599.6 ETO30900.1 - 0.0018 18.4 0.5 0.0092 16.1 0.2 2.4 1 1 1 2 2 2 2 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO30900.1 - 0.0042 15.7 2.7 0.33 9.4 0.0 4.5 6 1 0 6 6 6 1 Cytochrome D1 heme domain AAA_18 PF13238.6 ETO30900.1 - 0.0047 17.5 0.1 0.058 13.9 0.0 2.5 2 0 0 2 2 2 1 AAA domain Nbas_N PF15492.6 ETO30900.1 - 0.005 16.2 4.5 1.1 8.6 0.0 5.2 5 2 2 8 8 8 1 Neuroblastoma-amplified sequence, N terminal Pentapeptide_3 PF13576.6 ETO30900.1 - 0.031 14.4 0.1 0.067 13.4 0.1 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA_16 PF13191.6 ETO30900.1 - 0.038 14.4 0.0 0.11 12.8 0.0 1.8 1 1 0 1 1 1 0 AAA ATPase domain ABC_tran PF00005.27 ETO30900.1 - 0.1 13.1 0.6 0.36 11.3 0.0 2.3 2 0 0 2 2 2 0 ABC transporter Pro_3_hydrox_C PF05373.11 ETO30901.1 - 0.041 14.0 0.3 0.46 10.6 0.0 2.6 2 1 0 2 2 2 0 L-proline 3-hydroxylase, C-terminal FSA_C PF10479.9 ETO30904.1 - 0.00032 19.0 7.2 0.00042 18.6 7.2 1.2 1 0 0 1 1 1 1 Fragile site-associated protein C-terminus Bul1_C PF04426.12 ETO30904.1 - 0.03 13.8 5.6 0.014 14.8 3.4 1.5 2 0 0 2 2 2 0 Bul1 C terminus Mucin PF01456.17 ETO30904.1 - 0.055 13.5 39.1 0.093 12.7 39.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein FAM199X PF15814.5 ETO30904.1 - 0.064 12.3 1.5 0.11 11.5 1.5 1.3 1 0 0 1 1 1 0 Protein family FAM199X MGC-24 PF05283.11 ETO30904.1 - 0.22 12.0 14.4 0.54 10.7 14.4 1.6 1 0 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin DUF2057 PF09829.9 ETO30904.1 - 0.93 9.6 10.2 1.6 8.8 10.2 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2057) HSL_N PF06350.12 ETO30905.1 - 0.03 13.3 0.9 0.041 12.9 0.9 1.2 1 0 0 1 1 1 0 Hormone-sensitive lipase (HSL) N-terminus DUF4298 PF14131.6 ETO30905.1 - 0.039 13.9 1.0 0.039 13.9 1.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4298) YabA PF06156.13 ETO30905.1 - 2.9 8.6 13.5 1 10.1 4.2 2.7 1 1 0 2 2 2 0 Initiation control protein YabA DUF948 PF06103.11 ETO30905.1 - 3.2 8.1 5.9 1.7e+02 2.6 4.3 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) zf-C3HC4_4 PF15227.6 ETO30906.1 - 1.1e-07 31.9 6.7 1.1e-07 31.9 6.7 2.4 2 1 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-C3HC4 PF00097.25 ETO30906.1 - 1.6e-07 31.0 7.6 1.6e-07 31.0 7.6 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO30906.1 - 1.7e-07 31.5 7.5 1.7e-07 31.5 7.5 2.9 3 0 0 3 3 3 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO30906.1 - 2.9e-07 30.2 8.2 2.9e-07 30.2 8.2 2.4 3 0 0 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO30906.1 - 1.3e-06 28.3 5.9 1.3e-06 28.3 5.9 2.8 3 0 0 3 3 3 1 RING-type zinc-finger zf-C3HC4_3 PF13920.6 ETO30906.1 - 1.5e-06 28.0 9.9 1.5e-06 28.0 9.9 2.1 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO30906.1 - 5e-06 26.4 7.8 5e-06 26.4 7.8 2.4 2 1 0 2 2 2 1 zinc-RING finger domain Baculo_IE-1 PF05290.11 ETO30906.1 - 0.0016 18.4 5.5 0.0035 17.3 5.5 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) zf-RING_10 PF16685.5 ETO30906.1 - 0.0045 17.1 3.7 0.0045 17.1 3.7 2.3 2 0 0 2 2 2 1 zinc RING finger of MSL2 Prok-RING_4 PF14447.6 ETO30906.1 - 0.007 16.2 9.0 0.007 16.2 9.0 2.2 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_4 PF14570.6 ETO30906.1 - 0.57 10.0 5.7 2.4 8.0 5.7 2.0 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Utp14 PF04615.13 ETO30906.1 - 2.9 6.3 50.1 4.2 5.8 50.1 1.1 1 0 0 1 1 1 0 Utp14 protein zf-rbx1 PF12678.7 ETO30906.1 - 3.2 8.1 14.7 0.18 12.1 5.8 3.3 2 2 0 2 2 2 0 RING-H2 zinc finger domain CAC1F_C PF16885.5 ETO30906.1 - 4.3 6.9 19.0 7.8 6.0 19.0 1.4 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term DUF1772 PF08592.11 ETO30908.1 - 0.13 12.5 5.0 0.2 12.0 1.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) RNA_pol_Rbc25 PF08292.12 ETO30910.1 - 6.3e-16 58.8 0.1 1.1e-15 58.0 0.1 1.5 1 1 0 1 1 1 1 RNA polymerase III subunit Rpc25 SHS2_Rpb7-N PF03876.17 ETO30910.1 - 0.0032 17.8 0.2 0.016 15.6 0.2 2.1 1 1 0 1 1 1 1 SHS2 domain found in N terminus of Rpb7p/Rpc25p/MJ0397 S1 PF00575.23 ETO30910.1 - 0.0044 17.3 0.0 0.013 15.9 0.0 1.7 1 0 0 1 1 1 1 S1 RNA binding domain Luteo_coat PF00894.18 ETO30910.1 - 0.017 15.0 0.1 0.026 14.4 0.1 1.2 1 0 0 1 1 1 0 Luteovirus coat protein DIPSY PF11763.8 ETO30910.1 - 0.085 13.0 0.2 1.5 9.0 0.1 2.1 2 0 0 2 2 2 0 Cell-wall adhesin ligand-binding C-terminal DUF3488 PF11992.8 ETO30911.1 - 0.006 15.6 1.8 0.006 15.6 1.8 2.6 3 0 0 3 3 3 1 Domain of unknown function (DUF3488) 30K_MP_C_Ter PF11330.8 ETO30911.1 - 0.021 14.2 0.0 0.041 13.2 0.0 1.4 1 0 0 1 1 1 0 C-Terminal of 30K viral movement proteins tRNA-synt_1e PF01406.19 ETO30912.1 - 4.5e-45 154.3 1.9 8.1e-45 153.4 1.9 1.4 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain tRNA-synt_1c PF00749.21 ETO30912.1 - 0.00041 19.4 0.2 0.0014 17.6 0.0 1.9 1 1 1 2 2 2 1 tRNA synthetases class I (E and Q), catalytic domain BST2 PF16716.5 ETO30912.1 - 0.55 10.9 9.0 6.1 7.5 0.8 3.4 3 0 0 3 3 3 0 Bone marrow stromal antigen 2 AAA_32 PF13654.6 ETO30912.1 - 2 7.1 11.8 0.051 12.3 3.7 2.0 2 0 0 2 2 2 0 AAA domain XhlA PF10779.9 ETO30912.1 - 8.3 6.7 11.4 1 9.6 2.2 3.1 3 0 0 3 3 3 0 Haemolysin XhlA CAP_GLY PF01302.25 ETO30915.1 - 3.7e-05 23.7 0.0 0.00016 21.6 0.0 2.0 2 0 0 2 2 2 1 CAP-Gly domain O_anti_polymase PF01901.16 ETO30916.1 - 0.0047 16.2 2.0 0.006 15.9 2.0 1.2 1 0 0 1 1 1 1 Putative O-antigen polymerase Nucleoside_tran PF01733.18 ETO30916.1 - 0.07 12.5 1.6 0.077 12.4 1.6 1.0 1 0 0 1 1 1 0 Nucleoside transporter Folate_carrier PF01770.18 ETO30916.1 - 0.084 11.6 2.2 0.097 11.4 2.2 1.2 1 0 0 1 1 1 0 Reduced folate carrier OATP PF03137.20 ETO30916.1 - 0.13 10.6 4.2 0.14 10.4 4.2 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Afi1 PF07792.12 ETO30916.1 - 0.16 12.5 7.4 0.28 11.7 7.4 1.4 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 ETO30916.1 - 0.22 11.2 5.5 0.25 11.1 5.5 1.2 1 0 0 1 1 1 0 Connexin MS_channel PF00924.18 ETO30917.1 - 0.005 16.4 0.2 0.0081 15.7 0.2 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel Kelch_1 PF01344.25 ETO30917.1 - 0.34 10.5 5.9 3.9 7.1 2.3 3.7 3 1 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO30917.1 - 1.2 9.5 5.5 4.2 7.8 0.2 3.3 3 1 0 3 3 3 0 Kelch motif Myb_DNA-bind_4 PF13837.6 ETO30918.1 - 0.0083 16.5 7.8 0.44 11.0 2.3 2.6 2 1 0 2 2 2 2 Myb/SANT-like DNA-binding domain DUF5398 PF17376.2 ETO30918.1 - 0.055 14.1 2.8 0.055 14.1 2.8 2.9 2 2 1 3 3 3 0 Family of unknown function (DUF5398) SLX9 PF15341.6 ETO30918.1 - 0.065 13.6 9.6 0.11 12.9 9.6 1.4 1 1 0 1 1 1 0 Ribosome biogenesis protein SLX9 EnY2 PF10163.9 ETO30918.1 - 0.24 11.8 7.6 2.3 8.7 1.8 3.1 2 1 0 2 2 2 0 Transcription factor e(y)2 Siah-Interact_N PF09032.11 ETO30918.1 - 0.39 11.1 4.7 0.97 9.8 0.3 3.2 1 1 1 2 2 2 0 Siah interacting protein, N terminal Peptidase_U57 PF05582.12 ETO30918.1 - 1.2 8.4 5.7 0.16 11.2 1.5 1.6 1 1 1 2 2 2 0 YabG peptidase U57 Choline_transpo PF04515.12 ETO30919.1 - 4.3e-74 249.6 34.4 4.3e-74 249.6 34.4 2.0 2 0 0 2 2 2 1 Plasma-membrane choline transporter CCSAP PF15748.5 ETO30920.1 - 0.055 13.6 2.0 0.062 13.5 2.0 1.1 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated NESP55 PF06390.12 ETO30920.1 - 0.21 11.2 5.6 0.26 10.9 5.6 1.1 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) WD40 PF00400.32 ETO30921.1 - 4.6e-63 207.7 12.8 2.1e-09 37.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30921.1 - 1.1e-18 67.3 3.2 0.0023 18.2 0.1 6.0 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30921.1 - 1.7e-10 40.4 1.8 0.026 13.5 0.0 6.1 1 1 6 7 7 7 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO30921.1 - 1.1e-09 38.1 6.8 0.013 14.9 0.1 4.2 3 1 2 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO30921.1 - 2.9e-09 36.1 4.9 0.11 11.1 0.0 6.2 2 1 3 6 6 6 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO30921.1 - 9.3e-05 21.5 0.1 0.16 10.9 0.0 4.0 3 1 2 5 5 5 1 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO30921.1 - 0.00017 21.4 5.9 2.6 8.1 0.1 5.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO30921.1 - 0.00022 19.9 1.8 0.33 9.5 0.0 3.1 1 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO30921.1 - 0.00022 21.3 1.3 30 4.7 0.0 4.8 3 2 2 5 5 5 0 Family of unknown function (DUF5570) Ricin_B_lectin PF00652.22 ETO30921.1 - 0.00066 19.9 0.2 0.035 14.3 0.0 2.9 1 1 2 4 4 4 2 Ricin-type beta-trefoil lectin domain Utp8 PF10395.9 ETO30921.1 - 0.028 13.0 0.3 1.6 7.1 0.0 2.8 1 1 1 3 3 3 0 Utp8 family PQQ PF01011.21 ETO30921.1 - 0.029 14.3 0.0 89 3.3 0.0 4.5 4 0 0 4 4 4 0 PQQ enzyme repeat Frtz PF11768.8 ETO30921.1 - 0.042 12.2 0.1 0.68 8.2 0.0 2.1 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF4999 PF16390.5 ETO30921.1 - 0.047 13.9 0.7 25 5.2 0.0 4.2 5 0 0 5 5 5 0 Domain of unknown function CNH PF00780.22 ETO30921.1 - 0.059 13.0 0.0 2.7 7.5 0.0 2.4 2 0 0 2 2 2 0 CNH domain PS_Dcarbxylase PF02666.15 ETO30921.1 - 0.28 10.7 3.0 2.3 7.7 0.2 3.3 2 2 0 3 3 3 0 Phosphatidylserine decarboxylase LAP1C PF05609.12 ETO30922.1 - 0.15 11.1 32.5 3.1 6.8 28.8 2.3 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) AF-4 PF05110.13 ETO30922.1 - 5.3 5.0 61.1 0.88 7.6 5.7 2.3 2 0 0 2 2 2 0 AF-4 proto-oncoprotein Hid1 PF12722.7 ETO30922.1 - 7.3 4.6 32.7 2.2 6.3 26.7 2.2 2 0 0 2 2 2 0 High-temperature-induced dauer-formation protein PB1 PF00564.24 ETO30923.1 - 8.8e-06 25.6 0.1 9.6e-05 22.2 0.1 2.4 1 1 0 1 1 1 1 PB1 domain zf-UBP PF02148.19 ETO30924.1 - 0.058 13.7 3.1 0.17 12.2 3.1 1.8 1 0 0 1 1 1 0 Zn-finger in ubiquitin-hydrolases and other protein DUF3246 PF11596.8 ETO30924.1 - 0.085 12.3 2.7 0.19 11.1 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) PH_12 PF16457.5 ETO30925.1 - 3.8e-10 40.4 2.8 4.4e-10 40.2 0.0 2.3 2 1 0 2 2 2 1 Pleckstrin homology domain SesA PF17107.5 ETO30925.1 - 0.00055 20.1 1.0 0.0013 18.9 1.0 1.6 1 0 0 1 1 1 1 N-terminal domain on NACHT_NTPase and P-loop NTPases Pox_Rif PF03340.13 ETO30925.1 - 0.0023 16.4 1.4 0.0029 16.1 1.4 1.2 1 0 0 1 1 1 1 Poxvirus rifampicin resistance protein Occludin_ELL PF07303.13 ETO30925.1 - 0.0045 17.7 8.0 0.44 11.3 3.2 2.3 1 1 1 2 2 2 2 Occludin homology domain DUF2730 PF10805.8 ETO30925.1 - 0.014 15.4 3.0 0.015 15.4 0.9 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2730) LemA PF04011.12 ETO30925.1 - 0.03 14.2 3.1 0.05 13.4 3.1 1.4 1 1 0 1 1 1 0 LemA family PilJ PF13675.6 ETO30925.1 - 0.094 12.7 0.1 0.17 11.9 0.1 1.5 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term PCRF PF03462.18 ETO30925.1 - 0.34 10.7 5.0 0.31 10.9 3.4 1.7 1 1 1 2 2 2 0 PCRF domain DUF3644 PF12358.8 ETO30925.1 - 2.7 8.5 6.2 1.1 9.8 0.6 3.1 2 1 2 4 4 4 0 Protein of unknown function (DUF3644) PT PF04886.12 ETO30926.1 - 1.3e-21 75.8 107.5 0.00012 21.5 11.1 6.0 2 1 2 4 4 4 3 PT repeat SDF PF00375.18 ETO30927.1 - 2.3e-76 257.4 24.1 1.2e-72 245.1 15.2 2.3 1 1 0 2 2 2 2 Sodium:dicarboxylate symporter family Mpp10 PF04006.12 ETO30927.1 - 0.02 13.3 20.8 0.028 12.9 20.8 1.1 1 0 0 1 1 1 0 Mpp10 protein Ribosomal_60s PF00428.19 ETO30927.1 - 0.021 15.4 5.2 0.021 15.4 5.2 2.8 2 0 0 2 2 2 0 60s Acidic ribosomal protein DNA_pol_phi PF04931.13 ETO30927.1 - 0.038 12.1 23.3 0.054 11.6 23.3 1.2 1 0 0 1 1 1 0 DNA polymerase phi DUF4746 PF15928.5 ETO30927.1 - 0.051 13.0 12.0 0.071 12.5 12.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Nop14 PF04147.12 ETO30927.1 - 0.077 11.2 22.4 0.11 10.7 22.4 1.1 1 0 0 1 1 1 0 Nop14-like family Glycoprotein_G PF00802.19 ETO30927.1 - 0.13 11.6 0.8 0.27 10.6 0.8 1.4 1 0 0 1 1 1 0 Pneumovirus attachment glycoprotein G CobT PF06213.12 ETO30927.1 - 0.17 11.2 18.5 0.27 10.6 18.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pox_Ag35 PF03286.14 ETO30927.1 - 0.2 11.4 15.8 0.34 10.7 15.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein BSP_II PF05432.11 ETO30927.1 - 0.27 10.9 25.6 0.42 10.3 25.6 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Peptidase_M56 PF05569.11 ETO30927.1 - 0.29 10.3 3.0 0.21 10.8 0.4 2.0 2 0 0 2 2 2 0 BlaR1 peptidase M56 BUD22 PF09073.10 ETO30927.1 - 0.45 9.8 20.3 0.73 9.1 20.3 1.3 1 0 0 1 1 1 0 BUD22 CPSF100_C PF13299.6 ETO30927.1 - 0.71 10.0 4.6 1.5 9.0 4.6 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF350 PF03994.14 ETO30927.1 - 0.76 10.0 0.0 0.76 10.0 0.0 4.2 4 0 0 4 4 4 0 Domain of Unknown Function (DUF350) Zip PF02535.22 ETO30927.1 - 0.92 8.7 12.2 0.34 10.1 8.5 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter TFB6 PF17110.5 ETO30927.1 - 1.4 8.6 10.5 3 7.6 10.5 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH CNDH2_C PF16858.5 ETO30927.1 - 1.7 8.4 13.9 2.6 7.8 13.9 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RRN3 PF05327.11 ETO30927.1 - 2.3 6.6 18.6 3.5 6.1 18.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF2722 PF10846.8 ETO30927.1 - 2.4 7.0 20.2 3.9 6.3 20.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) SDA1 PF05285.12 ETO30927.1 - 3.7 6.9 27.3 5.4 6.3 27.3 1.1 1 0 0 1 1 1 0 SDA1 NPR3 PF03666.13 ETO30927.1 - 6 5.5 8.7 9.3 4.9 8.7 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 AAA PF00004.29 ETO30928.1 - 2.2e-29 102.5 0.2 4.3e-29 101.6 0.2 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO30928.1 - 8.1e-08 31.9 0.0 1.5e-07 31.1 0.0 1.5 1 0 0 1 1 1 1 AAA+ lid domain Vps4_C PF09336.10 ETO30928.1 - 1.9e-05 24.6 0.0 4.2e-05 23.4 0.0 1.6 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_2 PF07724.14 ETO30928.1 - 0.054 13.6 0.0 0.075 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain (Cdc48 subfamily) PDZ PF00595.24 ETO30929.1 - 7.2e-08 32.7 0.0 2.6e-07 30.9 0.0 2.0 1 0 0 1 1 1 1 PDZ domain FYVE PF01363.21 ETO30929.1 - 5.5e-07 29.6 12.9 1.3e-06 28.4 12.9 1.6 1 0 0 1 1 1 1 FYVE zinc finger PDZ_6 PF17820.1 ETO30929.1 - 4.3e-06 26.5 0.0 7.6e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 PDZ domain MIT PF04212.18 ETO30929.1 - 0.0038 17.2 0.1 0.0038 17.2 0.1 2.4 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain Baculo_IE-1 PF05290.11 ETO30929.1 - 0.0062 16.5 0.4 0.013 15.4 0.4 1.5 1 0 0 1 1 1 1 Baculovirus immediate-early protein (IE-0) PDZ_2 PF13180.6 ETO30929.1 - 0.0085 16.4 0.0 0.03 14.7 0.0 1.9 1 0 0 1 1 1 1 PDZ domain NtCtMGAM_N PF16863.5 ETO30929.1 - 0.079 13.2 1.3 1.7 8.8 0.0 3.0 2 1 0 2 2 2 0 N-terminal barrel of NtMGAM and CtMGAM, maltase-glucoamylase DUF2951 PF11166.8 ETO30929.1 - 1 9.6 9.9 4.1 7.7 9.9 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF2951) zf-HIT PF04438.16 ETO30929.1 - 2.5 8.0 10.8 0.2 11.6 5.9 1.7 2 0 0 2 2 2 0 HIT zinc finger zinc-ribbons_6 PF07191.12 ETO30929.1 - 3.3 7.8 10.0 0.63 10.1 3.8 2.3 1 1 1 2 2 2 0 zinc-ribbons G0-G1_switch_2 PF15103.6 ETO30929.1 - 6.9 7.1 11.1 3.1 8.3 7.1 2.6 2 0 0 2 2 2 0 G0/G1 switch protein 2 EF-hand_1 PF00036.32 ETO30931.1 - 0.00071 19.0 0.4 0.0026 17.2 0.4 2.0 1 0 0 1 1 1 1 EF hand EF-hand_5 PF13202.6 ETO30931.1 - 0.0027 17.1 0.2 0.0076 15.7 0.2 1.8 1 0 0 1 1 1 1 EF hand EF-hand_6 PF13405.6 ETO30931.1 - 0.0096 15.8 0.3 0.034 14.1 0.3 1.9 1 0 0 1 1 1 1 EF-hand domain GNAT_acetyltran PF12746.7 ETO30931.1 - 0.088 12.4 2.3 0.26 10.8 2.3 1.9 1 0 0 1 1 1 0 GNAT acetyltransferase Msap1 PF17077.5 ETO30933.1 - 0.018 14.2 0.5 0.024 13.8 0.5 1.1 1 0 0 1 1 1 0 Mitotic spindle associated protein SHE1 Ribosomal_L28e PF01778.17 ETO30935.1 - 1.1e-33 116.4 0.0 1.1e-33 116.4 0.0 3.8 3 1 1 4 4 4 2 Ribosomal L28e protein family Mak16 PF04874.14 ETO30935.1 - 1.5e-10 41.6 9.4 1.5e-10 41.6 9.4 4.2 2 2 1 3 3 3 1 Mak16 protein C-terminal region PC4 PF02229.16 ETO30935.1 - 0.15 11.7 3.8 6.8 6.4 0.0 3.1 3 0 0 3 3 3 0 Transcriptional Coactivator p15 (PC4) 6PF2K PF01591.18 ETO30938.1 - 2e-49 167.9 1.0 5.6e-27 94.5 0.0 2.2 2 0 0 2 2 2 2 6-phosphofructo-2-kinase His_Phos_1 PF00300.22 ETO30938.1 - 7.9e-34 117.0 0.0 3e-33 115.1 0.0 1.8 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) AAA_33 PF13671.6 ETO30938.1 - 0.013 15.7 0.1 0.036 14.2 0.1 1.9 1 1 0 1 1 1 0 AAA domain KTI12 PF08433.10 ETO30938.1 - 0.024 14.1 0.0 0.048 13.1 0.0 1.5 1 0 0 1 1 1 0 Chromatin associated protein KTI12 Zeta_toxin PF06414.12 ETO30938.1 - 0.052 12.8 0.0 0.098 11.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin SWIRM-assoc_1 PF16495.5 ETO30939.1 - 0.0018 18.2 1.1 0.0039 17.1 1.1 1.5 1 0 0 1 1 1 1 SWIRM-associated region 1 Cse1 PF08506.10 ETO30941.1 - 0.017 14.0 1.7 0.031 13.1 0.1 2.3 3 0 0 3 3 3 0 Cse1 MID_MedPIWI PF18296.1 ETO30941.1 - 0.036 13.9 4.3 0.48 10.2 4.4 2.4 1 1 0 1 1 1 0 MID domain of medPIWI DUF1645 PF07816.11 ETO30941.1 - 0.17 12.5 3.7 11 6.6 1.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1645) INTS5_N PF14837.6 ETO30941.1 - 0.52 9.9 6.6 0.24 11.0 0.5 3.2 4 0 0 4 4 4 0 Integrator complex subunit 5 N-terminus DUF3446 PF11928.8 ETO30941.1 - 4.7 7.6 19.5 6.7 7.1 3.4 2.7 2 0 0 2 2 2 0 Early growth response N-terminal domain SUZ PF12752.7 ETO30941.1 - 5.6 7.8 8.7 3.2 8.6 0.5 2.9 3 0 0 3 3 3 0 SUZ domain Hyccin PF09790.9 ETO30942.1 - 4.4e-12 45.7 1.7 9.3e-06 25.0 0.4 2.5 2 0 0 2 2 2 2 Hyccin ETC_C1_NDUFA5 PF04716.14 ETO30942.1 - 0.13 12.1 0.1 0.35 10.7 0.1 1.7 1 0 0 1 1 1 0 ETC complex I subunit conserved region Neur_chan_memb PF02932.16 ETO30943.1 - 5.8 6.9 6.4 6.4 6.8 6.4 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region zf-CCHC PF00098.23 ETO30945.1 - 0.0044 17.0 0.6 0.0082 16.2 0.6 1.5 1 0 0 1 1 1 1 Zinc knuckle Seryl_tRNA_N PF02403.22 ETO30945.1 - 0.081 13.2 5.1 1.4 9.1 1.4 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain CD34_antigen PF06365.12 ETO30946.1 - 5.1e-05 23.0 1.2 0.00011 21.9 0.0 2.0 2 1 1 3 3 3 1 CD34/Podocalyxin family Cadherin_C_2 PF16492.5 ETO30946.1 - 0.0022 18.7 0.0 0.006 17.3 0.0 1.9 1 0 0 1 1 1 1 Cadherin cytoplasmic C-terminal Herpes_UL73 PF03554.13 ETO30946.1 - 0.0062 16.5 0.6 0.011 15.8 0.6 1.4 1 0 0 1 1 1 1 UL73 viral envelope glycoprotein SID-1_RNA_chan PF13965.6 ETO30946.1 - 0.019 13.4 2.7 0.056 11.8 2.7 1.6 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 TMEM192 PF14802.6 ETO30946.1 - 0.026 13.6 0.1 0.037 13.1 0.1 1.2 1 0 0 1 1 1 0 TMEM192 family Hum_adeno_E3A PF05393.11 ETO30946.1 - 0.026 14.5 0.1 0.047 13.7 0.1 1.4 1 0 0 1 1 1 0 Human adenovirus early E3A glycoprotein EphA2_TM PF14575.6 ETO30946.1 - 0.028 15.3 0.0 0.11 13.3 0.0 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain MLANA PF14991.6 ETO30946.1 - 0.04 14.2 0.0 0.09 13.1 0.0 1.6 1 0 0 1 1 1 0 Protein melan-A Chordopox_A13L PF05961.11 ETO30946.1 - 0.061 13.6 2.2 0.1 12.9 0.1 2.3 2 0 0 2 2 2 0 Chordopoxvirus A13L protein TMEM52 PF14979.6 ETO30946.1 - 0.065 13.2 0.2 0.15 11.9 0.2 1.6 1 0 0 1 1 1 0 Transmembrane 52 TMEM154 PF15102.6 ETO30946.1 - 0.38 10.6 9.7 0.86 9.5 3.2 2.9 2 1 0 2 2 2 0 TMEM154 protein family Connexin PF00029.19 ETO30946.1 - 0.48 10.1 2.7 2.4 7.9 2.8 2.0 1 1 0 1 1 1 0 Connexin Kei1 PF08552.11 ETO30946.1 - 0.49 10.2 3.6 7.3 6.4 3.6 2.2 1 1 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 BSP_II PF05432.11 ETO30947.1 - 0.029 14.1 11.2 0.03 14.0 10.5 1.3 1 1 0 1 1 1 0 Bone sialoprotein II (BSP-II) Codanin-1_C PF15296.6 ETO30947.1 - 0.24 11.5 7.2 0.041 14.0 3.1 1.8 2 0 0 2 2 2 0 Codanin-1 C-terminus FAM176 PF14851.6 ETO30947.1 - 1.8 8.2 11.2 1.3 8.7 4.4 2.1 2 0 0 2 2 2 0 FAM176 family Phage_Gp23 PF10669.9 ETO30947.1 - 2.1 8.7 11.5 2.1 8.7 2.9 2.3 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) PBP1_TM PF14812.6 ETO30947.1 - 4.2 7.8 11.9 13 6.2 0.2 2.2 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal SPOUT_MTase PF02590.17 ETO30947.1 - 8.7 6.3 7.5 1.7 8.6 1.9 2.0 1 1 1 2 2 2 0 Predicted SPOUT methyltransferase Connexin PF00029.19 ETO30947.1 - 9.3 5.9 9.0 2.1 8.0 2.3 2.0 2 0 0 2 2 2 0 Connexin Cytomega_UL20A PF05984.12 ETO30948.1 - 0.28 11.5 3.2 0.24 11.7 2.1 1.4 1 1 0 1 1 1 0 Cytomegalovirus UL20A protein MAPEG PF01124.18 ETO30949.1 - 0.092 12.6 0.0 0.41 10.6 0.0 2.1 1 0 0 1 1 1 0 MAPEG family Microtub_bd PF16796.5 ETO30950.1 - 0.0065 16.4 1.7 0.012 15.6 1.7 1.5 1 0 0 1 1 1 1 Microtubule binding Rox3 PF08633.10 ETO30950.1 - 0.42 10.9 7.0 0.046 14.0 2.3 1.7 2 0 0 2 2 2 0 Rox3 mediator complex subunit DUF5316 PF17247.2 ETO30951.1 - 0.11 12.5 0.2 0.11 12.5 0.2 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5316) AAA PF00004.29 ETO30952.1 - 0.056 13.9 0.0 0.13 12.7 0.0 1.6 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) RXLR PF16810.5 ETO30953.1 - 0.0011 19.4 1.4 0.0017 18.8 1.4 1.4 1 0 0 1 1 1 1 RXLR phytopathogen effector protein, Avirulence activity LAT PF15234.6 ETO30953.1 - 0.64 9.7 8.1 0.95 9.1 8.1 1.3 1 0 0 1 1 1 0 Linker for activation of T-cells Presenilin PF01080.17 ETO30953.1 - 1.3 7.7 3.0 1.7 7.3 3.0 1.2 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO30953.1 - 2.5 6.3 9.0 3 6.0 9.0 1.1 1 0 0 1 1 1 0 CDC45-like protein Ank_2 PF12796.7 ETO30954.1 - 0.0029 18.2 0.0 0.021 15.4 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO30954.1 - 0.026 15.0 0.0 0.35 11.4 0.0 2.5 2 0 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 ETO30954.1 - 0.03 14.8 0.1 0.28 11.9 0.0 2.7 2 0 0 2 2 2 0 Ankyrin repeat HEAT PF02985.22 ETO30955.1 - 1.3e-08 34.4 0.2 0.4 11.1 0.0 8.2 10 0 0 10 10 10 1 HEAT repeat HEAT_2 PF13646.6 ETO30955.1 - 2e-08 34.5 0.0 0.0027 18.0 0.0 4.9 3 1 3 6 6 6 1 HEAT repeats HEAT_EZ PF13513.6 ETO30955.1 - 0.0054 17.2 0.0 28 5.4 0.0 5.4 5 2 1 6 6 6 0 HEAT-like repeat Spore_III_AB PF09548.10 ETO30955.1 - 0.034 14.3 16.4 0.27 11.3 1.1 4.8 2 2 3 5 5 5 0 Stage III sporulation protein AB (spore_III_AB) HEAT_PBS PF03130.16 ETO30955.1 - 0.043 14.5 0.1 2.7 8.9 0.0 4.0 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat Antiterm PF03589.13 ETO30955.1 - 3.1 8.2 5.6 92 3.5 0.0 5.4 5 3 2 7 7 7 0 Antitermination protein LuxT_C PF18285.1 ETO30955.1 - 5.3 7.6 10.3 45 4.7 0.2 5.0 4 1 1 5 5 5 0 Tetracycline repressor LuxT C-terminal domain UPF0242 PF06785.11 ETO30956.1 - 0.054 13.6 21.8 0.028 14.5 19.6 1.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Exonuc_VII_L PF02601.15 ETO30956.1 - 1.8 8.1 11.0 2.5 7.6 11.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit NRBF2 PF08961.10 ETO30956.1 - 5.3 6.6 13.1 36 3.9 12.8 2.1 1 1 0 1 1 1 0 Nuclear receptor-binding factor 2, autophagy regulator DUF4407 PF14362.6 ETO30956.1 - 8.4 5.6 10.1 11 5.2 10.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 ETO30957.1 - 0.25 11.1 6.1 0.085 12.7 3.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) AFP_2 PF18815.1 ETO30957.1 - 1.1 9.6 3.8 2.4 8.5 1.0 2.4 2 0 0 2 2 2 0 Bacterial antifreeze protein repeat Mss4 PF04421.13 ETO30957.1 - 1.2 9.3 5.8 4.1 7.6 1.2 2.3 2 0 0 2 2 2 0 Mss4 protein BSP_II PF05432.11 ETO30958.1 - 0.067 12.9 7.6 0.082 12.6 7.6 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4549 PF15082.6 ETO30958.1 - 0.58 9.9 7.0 3.1 7.6 5.4 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4549) PT PF04886.12 ETO30961.1 - 1.1e-44 149.6 168.0 2.1e+03 -1.6 1.1 7.4 2 1 0 2 2 2 0 PT repeat SKG6 PF08693.10 ETO30961.1 - 0.0011 18.4 1.0 0.0023 17.3 1.0 1.7 1 0 0 1 1 1 1 Transmembrane alpha-helix domain CwsA PF10814.8 ETO30961.1 - 0.025 14.8 0.1 0.041 14.0 0.1 1.3 1 0 0 1 1 1 0 Cell wall synthesis protein CwsA Orf78 PF06024.12 ETO30961.1 - 0.18 12.1 0.0 0.18 12.1 0.0 3.6 3 1 0 3 3 3 0 Orf78 (ac78) Glycoprotein_G PF00802.19 ETO30961.1 - 5.2 6.4 74.4 0.033 13.6 23.3 3.7 1 1 2 3 3 3 0 Pneumovirus attachment glycoprotein G Pkinase PF00069.25 ETO30964.1 - 7.5e-38 130.4 3.3 1e-26 93.9 0.2 3.1 3 0 0 3 3 3 3 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30964.1 - 2.7e-19 69.5 2.1 7.9e-13 48.3 0.6 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase DUF1266 PF06889.11 ETO30964.1 - 5.5 7.0 6.9 12 5.9 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1266) CAP_GLY PF01302.25 ETO30965.1 - 0.12 12.5 0.0 0.21 11.6 0.0 1.4 1 0 0 1 1 1 0 CAP-Gly domain 3HCDH_N PF02737.18 ETO30968.1 - 1.9e-48 164.7 6.6 1.6e-28 99.8 0.7 2.2 2 0 0 2 2 2 2 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ETO30968.1 - 4.7e-35 120.1 0.0 9.5e-35 119.1 0.0 1.5 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ETO30968.1 - 0.02 15.1 1.2 0.17 12.1 0.1 2.2 2 0 0 2 2 2 0 NAD binding domain of 6-phosphogluconate dehydrogenase F420_oxidored PF03807.17 ETO30968.1 - 0.064 13.8 5.0 0.086 13.4 2.8 2.4 2 1 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent TetR_C_25 PF17933.1 ETO30968.1 - 0.077 13.3 0.0 0.22 11.9 0.0 1.7 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain Lipoprotein_17 PF04200.12 ETO30968.1 - 0.12 12.8 0.2 0.12 12.8 0.2 2.4 2 0 0 2 2 2 0 Lipoprotein associated domain Pkinase PF00069.25 ETO30969.1 - 3e-13 49.7 0.1 1.3e-12 47.7 0.0 1.8 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30969.1 - 0.0049 16.2 0.5 0.0089 15.3 0.0 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase WD40_like PF17005.5 ETO30971.1 - 0.033 13.5 2.0 0.054 12.8 1.8 1.3 1 1 0 1 1 1 0 WD40-like domain Pkinase PF00069.25 ETO30972.1 - 2.1e-57 194.5 1.6 8.1e-36 123.7 0.8 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO30972.1 - 9.8e-27 93.9 0.9 1.7e-19 70.2 0.6 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO30972.1 - 4.1e-05 23.0 0.1 9.6e-05 21.8 0.1 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO30972.1 - 0.00061 18.8 0.0 0.0012 17.9 0.0 1.4 1 0 0 1 1 1 1 Haspin like kinase domain Kinase-like PF14531.6 ETO30972.1 - 0.00079 18.8 3.1 0.016 14.5 0.1 2.6 2 2 0 2 2 2 2 Kinase-like APH PF01636.23 ETO30972.1 - 0.017 15.1 0.0 0.061 13.2 0.0 1.8 1 1 1 2 2 2 0 Phosphotransferase enzyme family XPC-binding PF09280.11 ETO30973.1 - 7.2e-11 41.7 16.7 7.2e-11 41.7 16.7 2.3 2 0 0 2 2 2 1 XPC-binding domain STI1 PF17830.1 ETO30973.1 - 0.00019 21.3 2.4 0.00019 21.3 2.4 3.1 2 1 0 3 3 3 1 STI1 domain UBA PF00627.31 ETO30973.1 - 0.0005 19.9 0.6 0.0005 19.9 0.6 2.4 2 0 0 2 2 2 1 UBA/TS-N domain DUF2464 PF10240.9 ETO30973.1 - 0.016 14.8 0.1 0.023 14.3 0.1 1.2 1 0 0 1 1 1 0 Multivesicular body subunit 12 DUF4834 PF16118.5 ETO30973.1 - 1.2 10.1 3.8 2.1 9.3 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EF-hand_7 PF13499.6 ETO30975.1 - 2.6e-06 27.8 3.0 0.22 12.0 0.3 4.1 4 1 0 4 4 4 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO30975.1 - 1.1e-05 24.9 1.7 0.26 11.3 0.0 4.2 4 0 0 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 ETO30975.1 - 0.0031 16.9 0.1 1.2 8.9 0.0 3.8 4 0 0 4 4 4 1 EF hand EF-hand_13 PF17958.1 ETO30975.1 - 0.023 14.5 0.4 11 5.9 0.0 3.2 3 1 0 3 3 3 0 EF-hand domain EF-hand_5 PF13202.6 ETO30975.1 - 0.08 12.5 0.0 0.67 9.6 0.0 2.4 2 0 0 2 2 2 0 EF hand PH PF00169.29 ETO30976.1 - 2.4e-09 37.6 0.1 5.1e-09 36.6 0.1 1.6 1 0 0 1 1 1 1 PH domain ANAPC4_WD40 PF12894.7 ETO30977.1 - 0.0058 16.9 0.0 0.078 13.3 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO30977.1 - 0.018 15.9 4.3 4.1 8.4 0.1 4.2 5 0 0 5 5 5 0 WD domain, G-beta repeat WD40 PF00400.32 ETO30978.1 - 0.072 14.0 0.0 20 6.2 0.0 3.0 2 0 0 2 2 2 0 WD domain, G-beta repeat KOW PF00467.29 ETO30980.1 - 4.4e-15 55.0 24.6 2e-05 24.4 0.1 7.4 7 0 0 7 7 7 6 KOW motif SR-25 PF10500.9 ETO30980.1 - 0.0059 16.2 2.0 0.0059 16.2 2.0 1.7 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein CDK2AP PF09806.9 ETO30980.1 - 0.17 11.9 0.7 0.44 10.6 0.7 1.6 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein Roc PF08477.13 ETO30981.1 - 9.1e-10 38.8 0.1 1.1e-09 38.5 0.1 1.0 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO30981.1 - 1.2e-05 25.0 0.0 1.5e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 Ras family MMR_HSR1 PF01926.23 ETO30981.1 - 0.0012 18.9 0.0 0.0016 18.5 0.0 1.1 1 0 0 1 1 1 1 50S ribosome-binding GTPase malic PF00390.19 ETO30981.1 - 0.076 12.8 0.0 0.091 12.6 0.0 1.2 1 0 0 1 1 1 0 Malic enzyme, N-terminal domain Ribosomal_S13 PF00416.22 ETO30982.1 - 0.0002 21.8 5.5 0.0038 17.6 1.6 2.7 2 1 1 3 3 3 2 Ribosomal protein S13/S18 Type2_restr_D3 PF16902.5 ETO30982.1 - 0.11 12.5 0.0 0.33 10.9 0.0 1.7 1 0 0 1 1 1 0 Type-2 restriction enzyme D3 domain EF-hand_7 PF13499.6 ETO30983.1 - 4.4e-09 36.7 0.2 0.00089 19.7 0.0 3.1 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO30983.1 - 9.1e-07 28.3 4.2 0.0089 15.9 0.1 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO30983.1 - 1.1e-06 27.7 1.8 0.0081 15.6 0.1 3.9 3 0 0 3 3 3 2 EF hand EF-hand_8 PF13833.6 ETO30983.1 - 0.00037 20.3 1.0 0.0021 17.9 0.1 2.6 3 0 0 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO30983.1 - 0.0013 18.2 0.7 0.01 15.3 0.2 2.6 2 0 0 2 2 2 1 EF hand DUF2052 PF09747.9 ETO30983.1 - 0.0042 17.2 13.4 0.0042 17.2 13.4 3.9 3 1 0 3 3 3 1 Coiled-coil domain containing protein (DUF2052) DUF5069 PF16798.5 ETO30983.1 - 0.0096 16.1 1.8 0.025 14.8 0.4 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF5069) COPI_C PF06957.11 ETO30983.1 - 0.049 12.4 6.4 0.097 11.4 6.4 1.6 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus LTD PF00932.19 ETO30984.1 - 0.00024 21.4 0.0 0.00053 20.3 0.0 1.5 1 1 0 1 1 1 1 Lamin Tail Domain HALZ PF02183.18 ETO30985.1 - 0.037 14.3 0.6 0.037 14.3 0.6 12.0 11 1 1 12 12 12 0 Homeobox associated leucine zipper DUF2335 PF10097.9 ETO30987.1 - 0.15 12.0 0.4 8.5 6.4 0.0 2.1 1 1 1 2 2 2 0 Predicted membrane protein (DUF2335) CAP PF00188.26 ETO30988.1 - 2e-14 54.5 0.0 2e-14 54.5 0.0 2.6 2 1 0 2 2 2 1 Cysteine-rich secretory protein family PUB PF09409.10 ETO30988.1 - 3.8e-14 52.4 0.1 8.3e-14 51.3 0.1 1.5 1 0 0 1 1 1 1 PUB domain Secretin_N_2 PF07655.13 ETO30988.1 - 3.6 8.2 20.1 0.29 11.7 14.1 2.2 2 0 0 2 2 2 0 Secretin N-terminal domain DSPc PF00782.20 ETO30989.1 - 4.1e-24 84.9 0.5 6.4e-24 84.3 0.5 1.3 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ETO30989.1 - 0.00016 22.0 0.2 0.00031 21.0 0.2 1.5 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase PF00102.27 ETO30989.1 - 0.0031 17.1 1.0 0.028 14.0 0.1 2.1 2 1 0 2 2 2 1 Protein-tyrosine phosphatase DSPn PF14671.6 ETO30989.1 - 0.016 15.7 0.6 0.028 14.9 0.6 1.5 1 1 0 1 1 1 0 Dual specificity protein phosphatase, N-terminal half UBA_4 PF14555.6 ETO30989.1 - 0.037 13.8 0.0 0.069 13.0 0.0 1.4 1 0 0 1 1 1 0 UBA-like domain TAP_C PF03943.13 ETO30989.1 - 0.067 12.8 0.2 0.21 11.3 0.0 1.9 2 0 0 2 2 2 0 TAP C-terminal domain WD40 PF00400.32 ETO30990.1 - 9.4e-56 184.5 22.3 3.9e-10 40.2 0.1 7.1 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30990.1 - 1.1e-17 64.0 2.8 0.00041 20.6 0.1 5.0 1 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30990.1 - 1.2e-12 47.4 0.9 0.13 11.2 0.0 5.2 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO30990.1 - 0.00014 21.7 2.0 0.16 12.0 0.1 4.6 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO30990.1 - 0.011 15.9 0.7 22 5.2 0.0 4.1 4 1 1 5 5 5 0 Strictosidine synthase WD40 PF00400.32 ETO30991.1 - 2.9e-54 179.8 17.4 1.1e-08 35.6 0.0 8.1 8 0 0 8 8 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30991.1 - 1.7e-21 76.3 2.1 0.00065 20.0 0.0 7.1 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO30991.1 - 3.1e-17 62.5 3.9 0.00031 19.8 0.1 6.8 2 1 6 8 8 8 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO30991.1 - 3.3e-08 33.2 6.2 1.8 8.6 0.1 6.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO30991.1 - 3.2e-07 29.4 3.7 0.41 9.2 0.2 4.7 1 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO30991.1 - 3.6e-07 29.8 6.1 0.0079 15.6 0.4 4.8 2 2 3 5 5 5 3 WD40-like domain Kelch_6 PF13964.6 ETO30991.1 - 2.8e-05 24.2 2.0 0.52 10.7 0.1 4.8 4 1 0 4 4 4 1 Kelch motif Nbas_N PF15492.6 ETO30991.1 - 5.9e-05 22.5 2.9 0.21 10.9 0.0 3.9 1 1 4 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO30991.1 - 7.4e-05 21.4 0.9 0.34 9.4 0.2 3.8 2 1 3 5 5 5 3 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO30991.1 - 0.00012 21.9 0.5 0.29 11.2 0.1 4.1 3 0 0 3 3 3 1 Kelch motif BBS2_Mid PF14783.6 ETO30991.1 - 0.00026 21.0 1.3 0.073 13.1 0.1 4.5 3 2 1 5 5 5 1 Ciliary BBSome complex subunit 2, middle region PALB2_WD40 PF16756.5 ETO30991.1 - 0.0012 17.8 0.5 0.099 11.5 0.1 2.8 1 1 0 2 2 2 1 Partner and localizer of BRCA2 WD40 domain Kelch_1 PF01344.25 ETO30991.1 - 0.0019 17.7 3.0 0.16 11.6 0.1 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO30991.1 - 0.0031 17.5 2.5 0.74 9.9 0.0 3.5 3 0 0 3 3 2 1 Kelch motif Me-amine-dh_H PF06433.11 ETO30991.1 - 0.013 14.4 0.1 2 7.2 0.0 3.0 3 1 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) DUF5570 PF17731.1 ETO30991.1 - 0.019 15.0 3.7 10 6.2 0.0 4.5 2 1 3 5 5 5 0 Family of unknown function (DUF5570) WI12 PF07107.11 ETO30991.1 - 0.32 11.1 3.0 19 5.5 0.1 4.1 3 1 0 4 4 4 0 Wound-induced protein WI12 Proteasome_A_N PF10584.9 ETO30991.1 - 1.8 8.3 7.5 1.5e+02 2.2 0.0 5.4 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO30992.1 - 3.7e-56 185.8 24.5 3.5e-11 43.5 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO30992.1 - 2e-23 82.5 4.4 0.00014 22.1 0.1 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO30992.1 - 1.9e-10 40.6 4.3 5.5e-05 22.6 0.4 3.1 2 1 1 3 3 3 2 WD40-like domain Ge1_WD40 PF16529.5 ETO30992.1 - 3.1e-09 36.2 0.8 0.96 8.3 0.0 5.1 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO30992.1 - 7.5e-06 24.7 1.4 0.063 11.8 0.0 3.3 1 1 1 3 3 3 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO30992.1 - 0.00024 21.2 0.7 4.2 7.5 0.0 4.3 2 2 3 5 5 5 1 Family of unknown function (DUF5570) Nucleoporin_N PF08801.11 ETO30992.1 - 0.00026 19.9 10.7 0.066 11.9 1.7 3.7 1 1 2 3 3 3 2 Nup133 N terminal like Mid2 PF04478.12 ETO30992.1 - 0.0025 17.7 0.7 8.6 6.2 0.0 3.8 2 2 2 4 4 4 2 Mid2 like cell wall stress sensor PD40 PF07676.12 ETO30992.1 - 0.0096 15.8 1.3 5.6 7.0 0.1 3.9 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Resistin PF06954.11 ETO30992.1 - 0.073 13.6 1.7 13 6.4 0.2 3.5 2 2 2 4 4 4 0 Resistin DUF4999 PF16390.5 ETO30992.1 - 0.15 12.3 3.1 3 8.2 0.1 3.3 3 1 0 3 3 3 0 Domain of unknown function DUF4578 PF15147.6 ETO30993.1 - 0.48 11.3 18.4 0.32 11.9 14.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4578) DUF4678 PF15727.5 ETO30993.1 - 3.6 6.8 11.2 5.9 6.0 11.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4678) Androgen_recep PF02166.16 ETO30993.1 - 9.4 4.9 10.6 17 4.1 10.6 1.5 1 0 0 1 1 1 0 Androgen receptor DUF5531 PF17671.1 ETO30994.1 - 0.37 10.6 7.2 0.04 13.8 0.8 2.3 1 1 0 2 2 2 0 Family of unknown function (DUF5531) LMBR1 PF04791.16 ETO30995.1 - 1e-22 80.8 1.9 1e-22 80.8 1.9 2.5 3 0 0 3 3 3 2 LMBR1-like membrane protein DUF3810 PF12725.7 ETO30995.1 - 0.0091 15.4 0.0 0.0091 15.4 0.0 3.8 3 2 2 5 5 5 1 Protein of unknown function (DUF3810) SurA_N_2 PF13623.6 ETO30995.1 - 0.46 10.3 3.0 5 7.0 0.3 3.4 3 0 0 3 3 3 0 SurA N-terminal domain OAD_gamma PF04277.13 ETO30995.1 - 0.69 10.5 0.0 0.69 10.5 0.0 5.8 9 0 0 9 9 9 0 Oxaloacetate decarboxylase, gamma chain DNA_pol3_delta2 PF13177.6 ETO30996.1 - 3.8e-07 30.0 0.0 6.5e-07 29.3 0.0 1.3 1 0 0 1 1 1 1 DNA polymerase III, delta subunit DNA_pol3_delta PF06144.13 ETO30996.1 - 0.00047 20.0 0.1 0.00065 19.5 0.1 1.2 1 0 0 1 1 1 1 DNA polymerase III, delta subunit Sigma54_activ_2 PF14532.6 ETO30996.1 - 0.0071 16.5 0.5 0.016 15.3 0.1 1.7 2 0 0 2 2 2 1 Sigma-54 interaction domain AAA PF00004.29 ETO30996.1 - 0.044 14.2 0.0 0.21 12.0 0.0 1.9 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Shikimate_DH PF01488.20 ETO30997.1 - 0.057 13.5 0.5 0.081 13.0 0.5 1.2 1 0 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase MGDG_synth PF06925.11 ETO30997.1 - 0.067 13.3 2.6 0.093 12.8 0.3 2.0 1 1 0 2 2 2 0 Monogalactosyldiacylglycerol (MGDG) synthase TPR_2 PF07719.17 ETO31000.1 - 7.8e-10 38.1 9.9 0.00028 20.8 0.7 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO31000.1 - 9.7e-09 35.0 19.7 0.00022 21.4 0.7 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31000.1 - 2.3e-08 33.5 15.0 0.00019 21.1 0.6 3.6 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31000.1 - 4e-06 26.6 11.3 0.067 13.4 1.8 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO31000.1 - 7.2e-06 26.4 6.5 3.1e-05 24.4 0.9 2.3 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO31000.1 - 1.8e-05 25.1 7.4 0.16 12.7 0.0 3.7 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31000.1 - 5.9e-05 23.6 0.3 2.2 9.3 0.0 3.2 1 1 2 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO31000.1 - 0.00011 22.4 13.2 0.063 13.6 6.8 3.1 1 1 1 2 2 2 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO31000.1 - 0.0059 16.8 13.0 0.012 15.8 11.4 2.0 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETO31000.1 - 0.0066 16.6 0.5 0.16 12.1 0.0 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO31000.1 - 0.017 14.4 3.4 0.66 9.1 0.5 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31000.1 - 0.27 11.9 1.6 15 6.3 0.9 2.2 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31000.1 - 0.32 11.1 5.8 15 5.9 0.7 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31000.1 - 2.3 8.0 10.0 1.1 9.0 1.4 3.5 3 1 1 4 4 4 0 TPR repeat DUF2722 PF10846.8 ETO31001.1 - 1.1 8.1 9.6 1 8.2 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) DUF2431 PF10354.9 ETO31005.1 - 3e-26 92.7 0.0 6.4e-26 91.6 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF2431) FUSC PF04632.12 ETO31005.1 - 0.17 10.4 0.1 0.23 10.0 0.1 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family RNA_pol_Rpc4 PF05132.14 ETO31006.1 - 0.0039 17.6 5.0 0.004 17.6 5.0 1.3 1 0 0 1 1 1 1 RNA polymerase III RPC4 RR_TM4-6 PF06459.12 ETO31006.1 - 0.046 13.6 13.5 0.053 13.4 13.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO31006.1 - 0.046 12.0 9.2 0.053 11.8 9.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO31006.1 - 0.058 11.5 7.5 0.066 11.3 7.5 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SDA1 PF05285.12 ETO31006.1 - 0.078 12.4 18.2 0.097 12.1 18.2 1.1 1 0 0 1 1 1 0 SDA1 YABBY PF04690.13 ETO31006.1 - 0.079 13.5 5.2 0.11 13.0 5.2 1.3 1 0 0 1 1 1 0 YABBY protein Tim54 PF11711.8 ETO31006.1 - 0.13 11.1 9.4 0.17 10.6 9.4 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CLN3 PF02487.17 ETO31006.1 - 0.16 11.0 2.1 0.18 10.8 2.1 1.1 1 0 0 1 1 1 0 CLN3 protein V_ATPase_I PF01496.19 ETO31006.1 - 0.18 9.7 7.5 0.19 9.6 7.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CobT PF06213.12 ETO31006.1 - 0.21 11.0 12.9 0.26 10.6 12.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Connexin PF00029.19 ETO31006.1 - 0.28 10.9 5.5 0.41 10.4 5.5 1.2 1 0 0 1 1 1 0 Connexin ALMT PF11744.8 ETO31006.1 - 0.72 8.6 4.1 0.7 8.7 4.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hid1 PF12722.7 ETO31006.1 - 0.77 7.8 4.8 0.78 7.8 4.8 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein RP-C_C PF11800.8 ETO31006.1 - 0.92 9.6 5.2 1.2 9.2 5.2 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Neur_chan_memb PF02932.16 ETO31006.1 - 1.2 9.1 4.0 1.3 9.0 4.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region NPR3 PF03666.13 ETO31006.1 - 1.2 7.8 8.8 1.5 7.5 8.8 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF913 PF06025.12 ETO31006.1 - 1.7 7.5 5.1 2 7.3 5.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Membralin PF09746.9 ETO31006.1 - 1.9 7.5 3.5 2.3 7.2 3.5 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO31006.1 - 2.7 6.7 9.0 3.4 6.3 9.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4407 PF14362.6 ETO31006.1 - 2.8 7.2 4.2 3 7.1 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) RPN2_C PF18004.1 ETO31006.1 - 5.3 6.9 18.3 0.47 10.4 13.9 1.5 2 0 0 2 2 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain SpoIIP PF07454.11 ETO31006.1 - 6.6 6.1 16.2 8.6 5.7 16.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) Zip PF02535.22 ETO31006.1 - 9.2 5.4 7.5 11 5.1 7.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter OATP PF03137.20 ETO31007.1 - 8.7e-05 21.0 0.3 0.0001 20.7 0.3 1.1 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family GWT1 PF06423.12 ETO31007.1 - 0.00082 19.5 0.3 0.002 18.3 0.1 1.8 2 0 0 2 2 2 1 GWT1 Ofd1_CTDD PF10637.9 ETO31007.1 - 0.003 16.9 2.5 0.0041 16.5 2.5 1.2 1 0 0 1 1 1 1 Oxoglutarate and iron-dependent oxygenase degradation C-term NicO PF03824.16 ETO31007.1 - 0.0033 16.8 0.0 0.0046 16.3 0.0 1.1 1 0 0 1 1 1 1 High-affinity nickel-transport protein FPN1 PF06963.12 ETO31007.1 - 0.015 13.9 0.2 0.023 13.3 0.2 1.2 1 0 0 1 1 1 0 Ferroportin1 (FPN1) DUF4834 PF16118.5 ETO31007.1 - 0.02 15.9 2.9 0.16 12.9 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) OAD_gamma PF04277.13 ETO31007.1 - 0.026 15.1 1.0 0.069 13.7 1.0 1.8 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Atrophin-1 PF03154.15 ETO31007.1 - 0.13 10.5 3.5 0.18 10.1 3.5 1.1 1 0 0 1 1 1 0 Atrophin-1 family TMEM208_SND2 PF05620.11 ETO31007.1 - 0.17 11.7 7.3 0.082 12.7 4.3 2.0 1 1 1 2 2 2 0 SRP-independent targeting protein 2/TMEM208 Brr6_like_C_C PF10104.9 ETO31007.1 - 0.68 9.7 0.0 0.68 9.7 0.0 2.5 3 0 0 3 3 3 0 Di-sulfide bridge nucleocytoplasmic transport domain PCI PF01399.27 ETO31009.1 - 7.7e-15 55.3 0.4 1.8e-14 54.1 0.1 1.8 2 0 0 2 2 2 1 PCI domain CSN4_RPN5_eIF3a PF18420.1 ETO31009.1 - 0.0022 18.1 0.0 0.0057 16.8 0.0 1.7 1 0 0 1 1 1 1 CSN4/RPN5/eIF3a helix turn helix domain HTH_17 PF12728.7 ETO31009.1 - 0.14 12.3 0.0 0.33 11.2 0.0 1.5 1 0 0 1 1 1 0 Helix-turn-helix domain LAP1C PF05609.12 ETO31010.1 - 0.095 11.8 13.6 0.15 11.1 13.6 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PolyA_pol_arg_C PF12626.7 ETO31010.1 - 0.21 11.6 4.1 0.5 10.4 4.1 1.6 1 0 0 1 1 1 0 Polymerase A arginine-rich C-terminus Connexin PF00029.19 ETO31010.1 - 4.1 7.1 11.8 4.9 6.8 3.4 2.4 2 0 0 2 2 2 0 Connexin DUF4318 PF14201.6 ETO31012.1 - 0.088 13.3 0.5 0.77 10.3 0.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4318) Rootletin PF15035.6 ETO31013.1 - 0.00076 19.5 13.7 0.00076 19.5 13.7 7.6 2 1 4 6 6 6 1 Ciliary rootlet component, centrosome cohesion HiaBD2 PF15403.6 ETO31013.1 - 0.55 10.7 2.5 3.7 8.0 0.1 3.4 3 0 0 3 3 3 0 HiaBD2_N domain of Trimeric autotransporter adhesin (GIN) CENP-M PF11111.8 ETO31014.1 - 0.038 13.2 0.0 0.051 12.8 0.0 1.2 1 0 0 1 1 1 0 Centromere protein M (CENP-M) Metallophos PF00149.28 ETO31014.1 - 0.06 13.8 0.0 0.11 13.0 0.0 1.3 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase FYRC PF05965.14 ETO31015.1 - 1.2e-21 76.6 0.0 2.5e-21 75.6 0.0 1.5 1 0 0 1 1 1 1 F/Y rich C-terminus FYRN PF05964.14 ETO31015.1 - 5.3e-14 51.8 0.2 9.7e-14 50.9 0.2 1.4 1 0 0 1 1 1 1 F/Y-rich N-terminus PDCD2_C PF04194.13 ETO31016.1 - 0.31 11.1 9.8 1.4 9.0 0.8 2.9 2 1 1 3 3 3 0 Programmed cell death protein 2, C-terminal putative domain DUF2508 PF10704.9 ETO31016.1 - 0.46 10.7 3.6 0.56 10.4 0.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) CDC45 PF02724.14 ETO31017.1 - 0.00037 19.0 16.2 0.00047 18.6 16.2 1.4 1 0 0 1 1 1 1 CDC45-like protein Bromodomain PF00439.25 ETO31017.1 - 0.00057 19.9 0.1 0.0014 18.6 0.1 1.7 1 0 0 1 1 1 1 Bromodomain ATG_C PF09333.11 ETO31017.1 - 0.0089 16.3 0.1 0.028 14.8 0.1 1.8 1 0 0 1 1 1 1 Autophagy-related protein C terminal domain Bromodomain PF00439.25 ETO31018.1 - 9.7e-13 48.0 0.2 2.7e-12 46.6 0.2 1.7 1 0 0 1 1 1 1 Bromodomain Bromodomain PF00439.25 ETO31019.1 - 6.5e-05 22.9 1.2 8.6e-05 22.5 0.1 1.8 2 0 0 2 2 2 1 Bromodomain zf-B_box PF00643.24 ETO31019.1 - 0.00081 19.5 12.9 0.00081 19.5 12.9 2.6 2 1 0 2 2 2 1 B-box zinc finger zf-RING_5 PF14634.6 ETO31019.1 - 0.97 9.5 18.0 0.58 10.2 5.4 2.9 2 1 0 2 2 2 0 zinc-RING finger domain RecR PF02132.15 ETO31019.1 - 1.6 8.4 16.2 0.075 12.6 3.4 3.0 1 1 1 2 2 2 0 RecR protein zf-UDP PF14569.6 ETO31019.1 - 7.1 6.8 12.2 0.73 10.0 5.1 2.2 1 1 1 2 2 2 0 Zinc-binding RING-finger NIF PF03031.18 ETO31020.1 - 1.1e-42 145.4 0.1 1.1e-42 145.4 0.1 1.5 2 0 0 2 2 2 1 NLI interacting factor-like phosphatase Cpn60_TCP1 PF00118.24 ETO31021.1 - 1.8e-14 53.3 0.0 3.1e-14 52.5 0.0 1.4 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Cpn60_TCP1 PF00118.24 ETO31022.1 - 2.9e-17 62.5 0.0 3.2e-17 62.3 0.0 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family Ank_2 PF12796.7 ETO31023.1 - 6.4e-09 36.3 0.2 2.7e-08 34.3 0.1 2.2 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO31023.1 - 7e-08 32.6 0.3 0.00018 21.8 0.1 3.0 2 0 0 2 2 2 2 Ankyrin repeat Ank_4 PF13637.6 ETO31023.1 - 5.8e-05 23.6 0.1 0.0002 21.9 0.1 2.0 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO31023.1 - 8.1e-05 22.7 0.2 0.042 14.4 0.0 3.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO31023.1 - 0.00021 21.5 0.1 0.00048 20.4 0.1 1.7 1 0 0 1 1 1 1 Ankyrin repeats (many copies) WD40 PF00400.32 ETO31023.1 - 0.0026 18.5 4.1 0.35 11.8 1.1 4.5 3 1 0 3 3 3 1 WD domain, G-beta repeat DUF948 PF06103.11 ETO31023.1 - 0.068 13.4 0.8 0.33 11.2 0.2 2.4 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) ANAPC4_WD40 PF12894.7 ETO31023.1 - 0.069 13.4 0.0 1.4 9.2 0.0 2.8 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3507 PF12015.8 ETO31024.1 - 0.0024 17.6 2.4 0.0045 16.7 2.4 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3507) Alpha_E2_glycop PF00943.19 ETO31024.1 - 0.093 11.4 0.0 0.13 11.0 0.0 1.2 1 0 0 1 1 1 0 Alphavirus E2 glycoprotein TLD PF07534.16 ETO31027.1 - 4.3e-14 52.9 2.0 4.3e-14 52.9 2.0 1.8 2 1 0 2 2 2 1 TLD Ferlin_C PF16165.5 ETO31027.1 - 0.054 13.4 0.2 0.083 12.8 0.2 1.3 1 0 0 1 1 1 0 Ferlin C-terminus DUF4140 PF13600.6 ETO31028.1 - 0.14 12.6 0.6 0.43 11.0 0.6 1.9 1 0 0 1 1 1 0 N-terminal domain of unknown function (DUF4140) zf-met PF12874.7 ETO31030.1 - 2.4e-05 24.6 12.2 0.015 15.7 0.4 3.7 3 0 0 3 3 3 2 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ETO31030.1 - 6.9e-05 23.1 29.5 0.00012 22.3 0.9 5.2 5 0 0 5 5 5 2 Zinc finger, C2H2 type zf-C2H2_jaz PF12171.8 ETO31030.1 - 0.00017 21.8 13.6 0.024 14.9 0.1 3.8 3 0 0 3 3 3 2 Zinc-finger double-stranded RNA-binding zf-H2C2_2 PF13465.6 ETO31030.1 - 0.0013 19.1 23.6 0.01 16.2 0.9 5.1 4 1 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO31030.1 - 0.0097 16.7 32.3 0.02 15.7 0.6 5.8 5 0 0 5 5 5 3 C2H2-type zinc finger DUF896 PF05979.12 ETO31030.1 - 0.03 14.2 0.2 0.13 12.2 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF896) zf_C2H2_ZHX PF18387.1 ETO31030.1 - 0.69 9.6 0.0 0.69 9.6 0.0 4.2 5 1 0 5 5 5 0 Zinc-fingers and homeoboxes C2H2 finger domain CAF1A PF12253.8 ETO31031.1 - 0.036 14.2 0.6 0.07 13.3 0.1 1.7 2 0 0 2 2 2 0 Chromatin assembly factor 1 subunit A DUF3188 PF11384.8 ETO31031.1 - 0.063 13.0 0.4 0.11 12.2 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3188) DUF3605 PF12239.8 ETO31032.1 - 8.6e-29 100.8 4.6 1.1e-28 100.5 4.6 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3605) Baculo_LEF-11 PF06385.12 ETO31032.1 - 0.027 15.0 0.2 0.077 13.5 0.0 1.7 2 0 0 2 2 2 0 Baculovirus LEF-11 protein PUL PF08324.11 ETO31033.1 - 0.039 13.2 0.5 0.1 11.8 0.5 1.7 1 0 0 1 1 1 0 PUL domain TraI_2_C PF07515.11 ETO31036.1 - 0.053 13.5 6.1 0.047 13.6 3.8 2.0 1 1 1 2 2 2 0 Putative conjugal transfer nickase/helicase TraI C-term Pkinase PF00069.25 ETO31037.1 - 2.3e-75 253.4 0.1 3.7e-75 252.7 0.1 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31037.1 - 1.5e-46 158.8 0.0 2.6e-46 158.0 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO31037.1 - 2.9e-08 33.4 0.6 8.2e-08 31.9 0.0 1.8 2 1 0 2 2 2 1 Kinase-like RIO1 PF01163.22 ETO31037.1 - 4.9e-05 23.0 0.5 0.00018 21.2 0.7 1.9 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 ETO31037.1 - 0.0025 17.2 0.1 0.0025 17.2 0.1 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO31037.1 - 0.013 15.4 0.5 0.13 12.1 0.5 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family Cys_box PF17869.1 ETO31037.1 - 0.015 15.4 4.6 0.048 13.8 4.1 2.1 2 0 0 2 2 2 0 Anosmin cysteine rich domain TMEM173 PF15009.6 ETO31038.1 - 0.032 13.4 0.0 0.06 12.5 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 173 EF-hand_7 PF13499.6 ETO31040.1 - 8.7e-13 48.5 2.0 3.3e-05 24.2 0.1 3.5 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO31040.1 - 1.7e-12 45.9 1.9 5.1e-07 28.8 0.1 2.6 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO31040.1 - 2.1e-11 42.8 2.2 1.7e-05 24.4 0.1 2.9 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO31040.1 - 8e-10 37.8 2.9 2.1e-05 23.8 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO31040.1 - 8.5e-08 31.9 2.8 9.7e-05 22.1 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain pair p25-alpha PF05517.12 ETO31040.1 - 0.024 14.8 11.0 0.26 11.4 4.0 3.3 2 1 2 4 4 4 0 p25-alpha EF-hand_4 PF12763.7 ETO31040.1 - 0.22 11.5 4.6 14 5.7 0.3 3.3 2 2 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand EF-hand_10 PF14788.6 ETO31040.1 - 0.34 10.8 5.7 2.8 7.9 0.2 2.9 3 0 0 3 3 3 0 EF hand DUF2838 PF10998.8 ETO31041.1 - 0.22 11.8 2.8 0.28 11.4 1.6 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) Sec23_trunk PF04811.15 ETO31043.1 - 6.5e-30 104.5 0.0 4.2e-28 98.6 0.0 2.4 1 1 0 1 1 1 1 Sec23/Sec24 trunk domain Sec23_BS PF08033.12 ETO31043.1 - 3.2e-16 59.9 0.0 1.1e-15 58.2 0.0 2.0 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain zf-Sec23_Sec24 PF04810.15 ETO31043.1 - 2.1e-11 43.7 4.5 4.8e-11 42.5 4.5 1.7 1 0 0 1 1 1 1 Sec23/Sec24 zinc finger Sec23_helical PF04815.15 ETO31043.1 - 2.1e-09 37.1 0.0 5.1e-09 35.9 0.0 1.7 1 0 0 1 1 1 1 Sec23/Sec24 helical domain Secretin_N_2 PF07655.13 ETO31043.1 - 0.22 12.1 24.8 0.24 12.0 7.9 3.4 3 0 0 3 3 3 0 Secretin N-terminal domain MRNIP PF15749.5 ETO31043.1 - 1.1 10.1 10.4 6.3 7.6 0.1 3.5 3 0 0 3 3 3 0 MRN-interacting protein SR-25 PF10500.9 ETO31043.1 - 3.2 7.3 8.6 7.9 6.0 8.6 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Arf PF00025.21 ETO31044.1 - 2.2e-59 199.8 0.1 2.7e-59 199.5 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO31044.1 - 4.4e-16 59.2 0.0 5.7e-16 58.8 0.0 1.1 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ETO31044.1 - 2.6e-14 53.2 0.4 1.8e-10 40.6 0.1 2.3 1 1 1 2 2 2 2 G-protein alpha subunit Ras PF00071.22 ETO31044.1 - 9.3e-14 51.3 0.0 1.1e-13 51.1 0.0 1.1 1 0 0 1 1 1 1 Ras family Gtr1_RagA PF04670.12 ETO31044.1 - 1.5e-12 47.4 0.0 1.8e-12 47.1 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region SRPRB PF09439.10 ETO31044.1 - 3e-10 39.8 0.0 3.9e-10 39.5 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO31044.1 - 2.9e-07 30.6 0.0 4.4e-07 30.0 0.0 1.3 1 0 0 1 1 1 1 50S ribosome-binding GTPase cobW PF02492.19 ETO31044.1 - 0.012 15.3 0.4 3.8 7.1 0.0 2.1 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain SRP54 PF00448.22 ETO31044.1 - 0.021 14.4 0.0 0.072 12.7 0.0 1.8 2 0 0 2 2 2 0 SRP54-type protein, GTPase domain RsgA_GTPase PF03193.16 ETO31044.1 - 0.039 13.9 0.2 3 7.7 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase FeoB_N PF02421.18 ETO31044.1 - 0.042 13.4 0.8 0.2 11.2 0.8 1.9 1 1 0 1 1 1 0 Ferrous iron transport protein B ABC_tran PF00005.27 ETO31044.1 - 0.051 14.1 0.6 0.18 12.3 0.6 1.8 1 1 0 1 1 1 0 ABC transporter NACHT PF05729.12 ETO31044.1 - 0.062 13.2 0.0 5.3 6.9 0.0 2.1 2 0 0 2 2 2 0 NACHT domain AAA_14 PF13173.6 ETO31044.1 - 0.09 12.8 0.6 1.6 8.7 0.0 2.0 1 1 1 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO31044.1 - 0.094 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_18 PF13238.6 ETO31044.1 - 0.1 13.2 0.1 0.13 12.8 0.1 1.4 1 1 0 1 1 1 0 AAA domain Apolipoprotein PF01442.18 ETO31045.1 - 0.12 12.2 12.5 0.37 10.7 12.5 1.7 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DUF883 PF05957.13 ETO31045.1 - 0.97 10.1 6.6 7.9 7.2 0.1 2.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF883) NIF PF03031.18 ETO31046.1 - 8e-39 132.9 0.3 1.4e-38 132.1 0.3 1.4 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Spt20 PF12090.8 ETO31046.1 - 0.29 10.7 12.4 0.58 9.7 12.4 1.4 1 0 0 1 1 1 0 Spt20 family Androgen_recep PF02166.16 ETO31046.1 - 1 8.2 4.5 1.4 7.7 4.5 1.1 1 0 0 1 1 1 0 Androgen receptor Gly_transf_sug PF04488.15 ETO31047.1 - 1.1e-10 42.0 0.0 6e-10 39.6 0.0 2.3 1 0 0 1 1 1 1 Glycosyltransferase sugar-binding region containing DXD motif CPSF100_C PF13299.6 ETO31047.1 - 0.019 15.1 1.5 0.041 14.1 1.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal TcdA_TcdB PF12919.7 ETO31047.1 - 0.023 14.0 8.9 0.072 12.4 0.0 2.7 3 0 0 3 3 3 0 TcdA/TcdB catalytic glycosyltransferase domain LIM_bind PF01803.16 ETO31047.1 - 1 8.8 9.3 0.79 9.2 0.9 2.3 2 0 0 2 2 2 0 LIM-domain binding protein RRM_1 PF00076.22 ETO31048.1 - 1e-33 114.9 0.9 1.2e-18 66.7 0.0 4.5 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RBM39linker PF15519.6 ETO31048.1 - 1.6e-12 48.3 1.0 1.6e-12 48.3 1.0 2.2 2 1 0 2 2 2 1 linker between RRM2 and RRM3 domains in RBM39 protein RRM_5 PF13893.6 ETO31048.1 - 0.0041 16.7 0.1 0.012 15.2 0.1 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO31048.1 - 0.0042 16.9 0.0 0.052 13.4 0.0 2.5 3 0 0 3 3 3 1 Occluded RNA-recognition motif DUF1866 PF08952.11 ETO31048.1 - 0.078 12.8 0.0 16 5.3 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF1866) WD40 PF00400.32 ETO31049.1 - 3.3e-33 113.2 21.7 8.7e-07 29.5 2.3 7.0 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31049.1 - 9.4e-11 41.9 1.1 0.0043 17.3 0.0 5.1 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31049.1 - 2.6e-10 39.6 4.8 0.02 13.5 0.2 4.9 1 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31049.1 - 3.4e-07 29.9 6.1 0.0046 16.3 0.1 4.5 4 0 0 4 4 4 3 WD40-like domain SUKH_5 PF14567.6 ETO31049.1 - 0.12 12.1 2.5 0.38 10.5 0.4 2.7 2 1 1 3 3 3 0 SMI1-KNR4 cell-wall DNA_pol_A_exo1 PF01612.20 ETO31052.1 - 3.3e-08 33.4 0.6 9.4e-08 32.0 0.2 1.9 2 0 0 2 2 2 1 3'-5' exonuclease Myb_DNA-binding PF00249.31 ETO31053.1 - 2.1e-09 37.4 0.1 4e-09 36.5 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO31053.1 - 2.1e-05 24.7 0.0 5.1e-05 23.4 0.0 1.7 1 0 0 1 1 1 1 Myb-like DNA-binding domain DUF2207 PF09972.9 ETO31053.1 - 0.00012 21.0 0.7 0.00014 20.8 0.7 1.2 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Tmemb_9 PF05434.11 ETO31053.1 - 0.0015 18.4 9.9 0.0041 17.0 9.9 1.7 1 1 0 1 1 1 1 TMEM9 TMEM154 PF15102.6 ETO31053.1 - 0.0049 16.8 12.9 0.023 14.6 12.9 2.0 1 1 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 ETO31053.1 - 0.0056 17.0 12.2 0.0093 16.3 11.7 1.7 1 1 0 1 1 1 1 Orf78 (ac78) RIFIN PF02009.16 ETO31053.1 - 0.0056 16.6 10.8 0.0056 16.6 10.8 1.4 1 1 0 1 1 1 1 Rifin EVI2A PF05399.11 ETO31053.1 - 0.017 14.7 2.3 0.026 14.1 2.3 1.3 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) DHHC PF01529.20 ETO31053.1 - 0.033 14.3 0.1 0.064 13.4 0.1 1.5 1 0 0 1 1 1 0 DHHC palmitoyltransferase ZZ PF00569.17 ETO31053.1 - 0.049 13.5 0.9 0.079 12.8 0.9 1.4 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF4448 PF14610.6 ETO31053.1 - 0.068 12.9 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) Ammonium_transp PF00909.21 ETO31053.1 - 0.08 11.6 0.2 0.11 11.2 0.2 1.1 1 0 0 1 1 1 0 Ammonium Transporter Family Calcyon PF06387.11 ETO31053.1 - 0.14 12.1 3.7 0.18 11.8 2.2 1.7 1 1 1 2 2 2 0 D1 dopamine receptor-interacting protein (calcyon) Shisa PF13908.6 ETO31053.1 - 0.2 11.9 0.1 0.36 11.1 0.0 1.4 2 0 0 2 2 1 0 Wnt and FGF inhibitory regulator MENTAL PF10457.9 ETO31053.1 - 0.2 11.4 7.8 0.078 12.8 5.1 1.7 1 1 0 1 1 1 0 Cholesterol-capturing domain DUF1676 PF07898.13 ETO31053.1 - 0.22 11.6 7.1 0.18 11.8 4.5 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1676) DUF3377 PF11857.8 ETO31053.1 - 1.1 9.2 12.4 3.4 7.7 12.4 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3377) MMPL PF03176.15 ETO31053.1 - 2 7.3 5.3 2.8 6.8 5.3 1.1 1 0 0 1 1 1 0 MMPL family DUF3899 PF13038.6 ETO31053.1 - 3 8.4 10.3 29 5.2 10.7 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3899) Wzy_C PF04932.15 ETO31053.1 - 3.1 7.4 8.8 0.76 9.4 4.0 2.0 2 0 0 2 2 2 0 O-Antigen ligase V_ATPase_I PF01496.19 ETO31054.1 - 7.9e-241 801.4 14.3 8.9e-241 801.2 14.3 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family ANAPC2 PF08672.11 ETO31054.1 - 0.029 14.9 0.1 0.68 10.5 0.1 2.7 2 0 0 2 2 2 0 Anaphase promoting complex (APC) subunit 2 PSK_trans_fac PF07704.11 ETO31054.1 - 0.93 10.3 5.9 4.2 8.2 0.8 2.8 2 0 0 2 2 2 0 Rv0623-like transcription factor YbaB_DNA_bd PF02575.16 ETO31054.1 - 2.8 8.2 5.8 0.6 10.4 0.3 2.7 2 1 1 3 3 3 0 YbaB/EbfC DNA-binding family Snf7 PF03357.21 ETO31056.1 - 5.4e-07 29.4 7.4 6.6e-07 29.1 7.4 1.1 1 0 0 1 1 1 1 Snf7 PspA_IM30 PF04012.12 ETO31056.1 - 0.0048 16.5 1.5 0.0059 16.2 1.5 1.2 1 0 0 1 1 1 1 PspA/IM30 family Ist1 PF03398.14 ETO31056.1 - 0.0072 16.3 0.8 0.0072 16.3 0.8 1.4 2 0 0 2 2 2 1 Regulator of Vps4 activity in the MVB pathway LMBR1 PF04791.16 ETO31056.1 - 0.064 12.2 1.6 0.07 12.0 1.6 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF948 PF06103.11 ETO31056.1 - 0.097 12.9 1.5 12 6.3 0.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) SHE3 PF17078.5 ETO31057.1 - 0.0023 17.7 1.7 0.0023 17.7 1.7 1.4 2 0 0 2 2 2 1 SWI5-dependent HO expression protein 3 YlqD PF11068.8 ETO31057.1 - 0.059 13.7 4.6 0.044 14.2 3.4 1.5 1 1 0 1 1 1 0 YlqD protein RRN3 PF05327.11 ETO31058.1 - 0.00025 19.8 20.2 0.00029 19.5 20.2 1.0 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO31058.1 - 0.0021 16.3 28.1 0.0023 16.2 28.1 1.1 1 0 0 1 1 1 1 DNA polymerase phi DUF913 PF06025.12 ETO31058.1 - 0.0053 15.8 3.0 0.0054 15.8 3.0 1.0 1 0 0 1 1 1 1 Domain of Unknown Function (DUF913) Mpp10 PF04006.12 ETO31058.1 - 0.0079 14.7 18.7 0.0086 14.6 18.7 1.0 1 0 0 1 1 1 1 Mpp10 protein BSP_II PF05432.11 ETO31058.1 - 0.008 15.9 14.4 0.012 15.4 14.4 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SDA1 PF05285.12 ETO31058.1 - 0.008 15.6 18.8 0.0092 15.4 18.8 1.1 1 0 0 1 1 1 1 SDA1 Nop14 PF04147.12 ETO31058.1 - 0.021 13.1 21.8 0.023 12.9 21.8 1.1 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO31058.1 - 0.024 12.9 15.7 0.025 12.9 15.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO31058.1 - 0.024 12.7 9.4 0.027 12.6 9.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CPSF100_C PF13299.6 ETO31058.1 - 0.034 14.3 2.7 0.037 14.2 2.7 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Vfa1 PF08432.10 ETO31058.1 - 0.069 13.5 8.5 0.087 13.2 8.5 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 PDDEXK_6 PF04720.12 ETO31058.1 - 0.077 12.9 6.1 0.1 12.5 6.1 1.3 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Prp18 PF02840.15 ETO31058.1 - 0.093 12.8 0.6 0.14 12.2 0.6 1.3 1 0 0 1 1 1 0 Prp18 domain DUF2457 PF10446.9 ETO31058.1 - 0.098 11.8 38.1 0.13 11.4 38.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) D123 PF07065.14 ETO31058.1 - 0.1 11.7 8.8 0.18 11.0 8.8 1.4 1 0 0 1 1 1 0 D123 DUF2796 PF10986.8 ETO31058.1 - 0.12 12.3 8.4 0.15 12.0 8.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2796) BUD22 PF09073.10 ETO31058.1 - 0.16 11.3 18.0 0.18 11.1 18.0 1.1 1 0 0 1 1 1 0 BUD22 CDC27 PF09507.10 ETO31058.1 - 0.27 10.6 10.8 0.32 10.3 10.8 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 CobT PF06213.12 ETO31058.1 - 0.37 10.1 22.6 0.48 9.8 22.6 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CNDH2_C PF16858.5 ETO31058.1 - 0.46 10.3 11.4 0.51 10.2 11.4 1.2 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term RNA_pol_Rpc4 PF05132.14 ETO31058.1 - 0.6 10.5 3.3 0.7 10.3 3.3 1.2 1 0 0 1 1 1 0 RNA polymerase III RPC4 TRAP_alpha PF03896.16 ETO31058.1 - 0.64 9.2 11.2 0.69 9.1 11.2 1.1 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit PI3K_1B_p101 PF10486.9 ETO31058.1 - 0.72 7.6 8.6 0.78 7.4 8.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Tim54 PF11711.8 ETO31058.1 - 0.73 8.6 6.0 0.81 8.4 6.0 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO31058.1 - 0.9 8.7 2.8 0.85 8.8 2.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter GCIP PF13324.6 ETO31058.1 - 0.91 9.1 14.5 1.1 8.8 14.5 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting Afi1 PF07792.12 ETO31058.1 - 1.3 9.5 12.2 1.9 9.0 12.2 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking XAP5 PF04921.14 ETO31058.1 - 2.3 8.0 11.0 3.2 7.5 11.0 1.2 1 0 0 1 1 1 0 XAP5, circadian clock regulator Paf1 PF03985.13 ETO31058.1 - 2.5 7.0 17.7 3.2 6.6 17.7 1.1 1 0 0 1 1 1 0 Paf1 Nop25 PF09805.9 ETO31058.1 - 3.8 8.0 19.2 4.5 7.7 15.1 2.0 2 0 0 2 2 2 0 Nucleolar protein 12 (25kDa) FAM176 PF14851.6 ETO31058.1 - 3.9 7.1 22.6 90 2.7 22.6 2.1 1 1 0 1 1 1 0 FAM176 family RPN2_C PF18004.1 ETO31058.1 - 4.4 7.2 9.3 5.4 6.9 9.3 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Roughex PF06020.11 ETO31058.1 - 5.1 6.1 14.7 5.5 6.0 14.7 1.1 1 0 0 1 1 1 0 Drosophila roughex protein SGT1 PF07093.11 ETO31058.1 - 5.3 5.4 14.0 5.6 5.3 14.0 1.1 1 0 0 1 1 1 0 SGT1 protein DUF4637 PF15470.6 ETO31058.1 - 6.6 6.4 19.3 10 5.8 19.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Adeno_E1A PF02703.14 ETO31059.1 - 0.095 12.3 1.7 0.13 11.9 1.7 1.2 1 0 0 1 1 1 0 Early E1A protein Suf PF05843.14 ETO31059.1 - 0.78 9.7 4.0 0.44 10.5 2.4 1.3 1 1 0 1 1 1 0 Suppressor of forked protein (Suf) ABC_tran PF00005.27 ETO31060.1 - 5.9e-28 98.1 0.0 1.2e-27 97.0 0.0 1.6 1 0 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO31060.1 - 1.6e-08 34.7 0.1 6.9e-06 26.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain, putative AbiEii toxin, Type IV TA system DUF4162 PF13732.6 ETO31060.1 - 0.026 15.2 0.0 0.069 13.9 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4162) AAA_23 PF13476.6 ETO31060.1 - 0.026 15.0 0.5 0.053 14.0 0.5 1.4 1 0 0 1 1 1 0 AAA domain SRP54 PF00448.22 ETO31060.1 - 0.04 13.5 0.3 0.074 12.7 0.3 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain SMC_N PF02463.19 ETO31060.1 - 0.045 13.2 0.0 0.58 9.6 0.0 2.2 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO31060.1 - 0.081 13.2 0.0 0.29 11.4 0.0 2.0 1 1 0 1 1 1 0 Putative exonuclease SbcCD, C subunit AAA_15 PF13175.6 ETO31060.1 - 0.081 12.6 0.0 1 9.0 0.0 2.1 2 0 0 2 2 2 0 AAA ATPase domain AAA_29 PF13555.6 ETO31060.1 - 0.18 11.5 0.2 0.39 10.5 0.2 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC2_membrane_3 PF12698.7 ETO31061.1 - 5.5e-11 42.2 3.1 8.2e-11 41.6 3.1 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein Phage_TTP_11 PF16460.5 ETO31061.1 - 0.0072 16.2 0.4 0.01 15.6 0.4 1.2 1 0 0 1 1 1 1 Phage tail tube, TTP, lambda-like Lon_C PF05362.13 ETO31063.1 - 4.4e-64 215.8 0.0 5.6e-64 215.5 0.0 1.1 1 0 0 1 1 1 1 Lon protease (S16) C-terminal proteolytic domain ChlI PF13541.6 ETO31063.1 - 2.3e-06 27.5 0.0 3.6e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 Subunit ChlI of Mg-chelatase Actin PF00022.19 ETO31064.1 - 7.7e-54 182.9 0.0 1.2e-53 182.2 0.0 1.2 1 0 0 1 1 1 1 Actin RIFIN PF02009.16 ETO31065.1 - 0.0055 16.6 0.2 0.011 15.7 0.2 1.4 1 0 0 1 1 1 1 Rifin Ly49 PF08391.10 ETO31065.1 - 0.01 16.2 1.2 0.023 15.1 0.3 2.0 2 0 0 2 2 2 0 Ly49-like protein, N-terminal region PIRT PF15099.6 ETO31065.1 - 0.015 14.9 0.3 0.039 13.5 0.1 1.8 2 0 0 2 2 2 0 Phosphoinositide-interacting protein family TMEM154 PF15102.6 ETO31065.1 - 0.022 14.7 0.1 0.054 13.4 0.1 1.6 1 0 0 1 1 1 0 TMEM154 protein family COX2_TM PF02790.15 ETO31065.1 - 0.025 14.7 1.7 5.1 7.3 0.3 2.5 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain ASFV_J13L PF05568.11 ETO31065.1 - 0.026 14.3 0.1 0.059 13.1 0.1 1.6 1 0 0 1 1 1 0 African swine fever virus J13L protein Vpu PF00558.19 ETO31065.1 - 0.042 13.6 2.3 0.11 12.3 0.3 2.3 2 0 0 2 2 2 0 Vpu protein DUF4307 PF14155.6 ETO31065.1 - 0.079 12.8 0.1 0.16 11.8 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4307) Ninjurin PF04923.12 ETO31065.1 - 0.11 12.4 2.3 1.3 9.0 0.2 2.5 2 1 0 2 2 2 0 Ninjurin MaAIMP_sms PF16951.5 ETO31065.1 - 0.15 11.8 0.4 0.33 10.7 0.4 1.5 1 0 0 1 1 1 0 Putative methionine and alanine importer, small subunit Ac76 PF05814.11 ETO31065.1 - 2.5 8.2 6.9 4.7 7.3 0.3 3.1 3 0 0 3 3 3 0 Orf76 (Ac76) Orf78 PF06024.12 ETO31065.1 - 3.6 7.9 7.0 0.47 10.8 0.2 2.6 3 0 0 3 3 3 0 Orf78 (ac78) Glyco_hydro_2_C PF02836.17 ETO31067.1 - 1.3e-06 27.7 0.0 1.6e-06 27.4 0.0 1.3 1 0 0 1 1 1 1 Glycosyl hydrolases family 2, TIM barrel domain ANAPC2 PF08672.11 ETO31068.1 - 0.14 12.7 0.1 0.28 11.7 0.1 1.5 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 Pex2_Pex12 PF04757.14 ETO31071.1 - 0.78 9.3 4.3 0.17 11.4 0.4 1.9 2 1 0 2 2 2 0 Pex2 / Pex12 amino terminal region TFIIA PF03153.13 ETO31071.1 - 1.6 8.7 35.9 1.9 8.4 35.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MscS_TM PF12794.7 ETO31071.1 - 2.2 7.0 5.2 4.1 6.2 5.2 1.4 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF3584 PF12128.8 ETO31072.1 - 0.0023 15.6 10.5 0.0026 15.4 10.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) DUF4710 PF15828.5 ETO31072.1 - 0.044 13.9 2.0 0.044 13.9 2.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) IFT57 PF10498.9 ETO31072.1 - 0.061 12.3 9.5 0.23 10.4 10.6 1.3 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 FlxA PF14282.6 ETO31072.1 - 0.064 13.2 5.9 0.096 12.7 5.9 1.2 1 0 0 1 1 1 0 FlxA-like protein OmpH PF03938.14 ETO31072.1 - 0.26 11.6 11.4 0.48 10.8 11.4 1.4 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2252 PF10009.9 ETO31072.1 - 0.29 10.1 3.2 0.39 9.7 3.2 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) SPT16 PF08644.11 ETO31072.1 - 0.41 10.8 7.9 0.45 10.7 6.4 1.7 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) Prefoldin_2 PF01920.20 ETO31072.1 - 1.3 9.0 16.4 0.087 12.8 1.8 2.3 1 1 1 2 2 2 0 Prefoldin subunit Zn_ribbon_2 PF12674.7 ETO31072.1 - 1.7 9.4 6.5 1.9 9.2 0.2 2.6 1 1 2 3 3 3 0 Putative zinc ribbon domain DUF3293 PF11697.8 ETO31073.1 - 5.1e-18 65.3 0.1 1e-17 64.4 0.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3293) Vps36-NZF-N PF16988.5 ETO31073.1 - 0.016 14.6 0.0 0.032 13.6 0.0 1.5 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Inj_translocase PF16928.5 ETO31074.1 - 0.36 10.2 4.7 0.49 9.8 4.7 1.1 1 0 0 1 1 1 0 DNA/protein translocase of phage P22 injectosome DUF4381 PF14316.6 ETO31074.1 - 1.9 8.7 7.9 1.9 8.7 0.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Ac81 PF05820.11 ETO31074.1 - 3.9 7.0 14.9 2.7 7.5 13.4 1.5 1 1 0 1 1 1 0 Baculoviridae AC81 GAS PF13851.6 ETO31076.1 - 1.9e-44 151.4 37.9 1.9e-44 151.4 37.9 2.4 2 0 0 2 2 2 1 Growth-arrest specific micro-tubule binding DHR10 PF18595.1 ETO31076.1 - 0.016 15.3 8.3 0.016 15.3 8.3 4.5 2 1 1 4 4 4 0 Designed helical repeat protein 10 domain ZapB PF06005.12 ETO31076.1 - 0.019 15.4 8.6 0.019 15.4 8.6 4.6 3 2 1 4 4 4 0 Cell division protein ZapB HALZ PF02183.18 ETO31076.1 - 0.074 13.3 1.4 0.074 13.3 1.4 4.8 5 2 1 6 6 6 0 Homeobox associated leucine zipper KorB PF08535.10 ETO31076.1 - 0.14 12.2 5.0 1.2 9.2 0.3 2.8 2 2 0 2 2 2 0 KorB domain FUSC PF04632.12 ETO31076.1 - 0.64 8.5 3.8 0.41 9.1 1.1 1.7 1 1 1 2 2 2 0 Fusaric acid resistance protein family SHE3 PF17078.5 ETO31076.1 - 7.2 6.3 49.6 0.12 12.0 33.8 3.1 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 Hid1 PF12722.7 ETO31077.1 - 0.023 12.9 2.5 0.031 12.4 2.5 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO31077.1 - 0.031 13.0 9.6 0.047 12.5 9.6 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO31077.1 - 0.098 11.6 2.3 0.15 11.0 2.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) Ndc1_Nup PF09531.10 ETO31077.1 - 0.17 10.6 1.1 0.24 10.1 1.1 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SAPS PF04499.15 ETO31077.1 - 0.18 10.6 6.9 0.25 10.1 6.9 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein Ctr PF04145.15 ETO31077.1 - 0.18 12.4 0.3 0.46 11.1 0.3 1.7 1 0 0 1 1 1 0 Ctr copper transporter family Neur_chan_memb PF02932.16 ETO31077.1 - 0.19 11.8 2.8 0.29 11.1 2.8 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SLC12 PF03522.15 ETO31077.1 - 0.47 9.4 9.1 0.87 8.5 9.1 1.4 1 0 0 1 1 1 0 Solute carrier family 12 Zip PF02535.22 ETO31077.1 - 0.52 9.5 5.8 0.78 8.9 5.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ALMT PF11744.8 ETO31077.1 - 0.71 8.6 6.3 1.2 7.9 6.3 1.3 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF5423 PF17461.2 ETO31077.1 - 1.6 7.5 3.9 2.9 6.7 3.9 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5423) DUF3915 PF13054.6 ETO31077.1 - 2.2 8.3 5.9 7.1 6.6 5.9 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) DUF4228 PF14009.6 ETO31077.1 - 3.6 8.0 8.5 7.1 7.0 8.5 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4228) DUF2151 PF10221.9 ETO31077.1 - 8.5 4.8 15.3 14 4.2 15.3 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator Suf PF05843.14 ETO31077.1 - 9.5 6.1 12.0 1.7 8.5 8.2 1.6 2 0 0 2 2 2 0 Suppressor of forked protein (Suf) Dynamin_N PF00350.23 ETO31078.1 - 0.061 13.4 0.8 0.14 12.2 0.8 1.6 1 0 0 1 1 1 0 Dynamin family DUF908 PF06012.12 ETO31078.1 - 0.15 11.5 3.8 0.24 10.8 3.8 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Herpes_DNAp_acc PF04929.12 ETO31078.1 - 1 8.2 6.7 2 7.3 6.7 1.4 1 0 0 1 1 1 0 Herpes DNA replication accessory factor FAM176 PF14851.6 ETO31078.1 - 5.8 6.6 9.2 3.9 7.1 4.6 2.4 2 0 0 2 2 2 0 FAM176 family Orf78 PF06024.12 ETO31078.1 - 7.9 6.8 6.9 87 3.5 3.2 3.0 3 0 0 3 3 3 0 Orf78 (ac78) START PF01852.19 ETO31079.1 - 1.4e-07 31.2 0.0 2.4e-07 30.4 0.0 1.3 1 0 0 1 1 1 1 START domain Pex14_N PF04695.13 ETO31079.1 - 0.03 15.0 1.8 0.03 15.0 1.8 1.8 2 0 0 2 2 2 0 Peroxisomal membrane anchor protein (Pex14p) conserved region PPO1_KFDV PF12143.8 ETO31079.1 - 0.037 14.1 0.7 0.075 13.1 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) SUIM_assoc PF16619.5 ETO31079.1 - 0.061 13.4 11.8 0.15 12.1 11.8 1.7 1 0 0 1 1 1 0 Unstructured region C-term to UIM in Ataxin3 EPL1 PF10513.9 ETO31079.1 - 0.6 10.5 15.0 9.6 6.6 15.0 2.4 1 1 0 1 1 1 0 Enhancer of polycomb-like Spt20 PF12090.8 ETO31079.1 - 0.99 9.0 15.1 2 8.0 15.1 1.4 1 0 0 1 1 1 0 Spt20 family DUF4834 PF16118.5 ETO31079.1 - 8.2 7.5 9.0 34 5.5 9.0 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Ank_2 PF12796.7 ETO31080.1 - 3.8e-43 146.0 4.7 7.5e-16 58.5 0.4 4.2 2 1 3 5 5 5 5 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO31080.1 - 3.4e-22 78.2 0.2 1.3e-05 25.4 0.0 5.7 3 1 3 6 6 6 5 Ankyrin repeats (many copies) Ank PF00023.30 ETO31080.1 - 1.9e-20 72.3 1.0 0.0077 16.6 0.0 6.6 6 0 0 6 6 6 4 Ankyrin repeat Ank_4 PF13637.6 ETO31080.1 - 3.3e-20 72.2 0.1 3.1e-10 40.4 0.0 4.8 3 1 2 5 5 5 4 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO31080.1 - 1.8e-19 67.8 0.2 0.00034 20.8 0.0 6.2 5 0 0 5 5 5 3 Ankyrin repeat Plant_tran PF04827.14 ETO31080.1 - 0.041 13.5 0.0 0.092 12.3 0.0 1.6 1 0 0 1 1 1 0 Plant transposon protein DUF4998 PF16389.5 ETO31080.1 - 0.097 12.2 0.2 0.18 11.4 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function DLP_helical PF18709.1 ETO31081.1 - 0.00049 19.4 0.8 0.00049 19.4 0.8 1.8 2 0 0 2 2 2 1 Dynamin-like helical domain DUF3583 PF12126.8 ETO31081.1 - 0.002 17.7 1.6 0.002 17.7 1.6 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF3583) B PF02216.16 ETO31081.1 - 0.0092 16.0 0.0 0.23 11.5 0.0 2.7 3 0 0 3 3 3 1 B domain HAP1_N PF04849.13 ETO31081.1 - 0.06 12.5 10.7 0.027 13.7 5.6 2.2 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Ferlin_C PF16165.5 ETO31081.1 - 0.19 11.6 0.1 0.19 11.6 0.1 2.5 2 0 0 2 2 2 0 Ferlin C-terminus LPP PF04728.13 ETO31081.1 - 0.45 10.9 4.1 9.4 6.7 0.2 2.9 2 1 0 2 2 2 0 Lipoprotein leucine-zipper Mit_KHE1 PF10173.9 ETO31081.1 - 1 9.4 5.2 0.37 10.9 1.4 2.0 2 0 0 2 2 2 0 Mitochondrial K+-H+ exchange-related FliD_N PF02465.18 ETO31081.1 - 2.4 8.9 22.3 10 6.9 0.3 3.4 2 1 1 3 3 3 0 Flagellar hook-associated protein 2 N-terminus ARA70 PF12489.8 ETO31081.1 - 7.3 6.8 9.3 1.1 9.5 2.2 2.7 2 1 0 2 2 2 0 Nuclear coactivator Adaptin_binding PF10199.9 ETO31081.1 - 8.3 7.0 8.8 11 6.6 4.4 2.7 2 1 0 2 2 2 0 Alpha and gamma adaptin binding protein p34 Tubulin PF00091.25 ETO31082.1 - 3.3e-54 184.1 0.0 5.1e-54 183.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO31082.1 - 3.9e-26 91.7 0.0 7.2e-26 90.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO31082.1 - 0.013 14.8 0.1 0.022 14.0 0.1 1.3 1 0 0 1 1 1 0 Tubulin like DUF2976 PF11190.8 ETO31083.1 - 0.053 13.3 1.9 0.11 12.4 1.7 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2976) DUF2370 PF10176.9 ETO31083.1 - 0.06 13.0 0.2 0.11 12.1 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2370) DUF4825 PF16107.5 ETO31083.1 - 0.07 13.3 1.6 0.49 10.5 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4825) Pik1 PF11522.8 ETO31083.1 - 0.2 11.6 1.3 1.2 9.1 0.1 2.3 2 0 0 2 2 2 0 Yeast phosphatidylinositol-4-OH kinase Pik1 WD40 PF00400.32 ETO31084.1 - 5.5e-52 172.6 24.0 1.1e-09 38.7 0.1 9.1 9 0 0 9 9 9 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31084.1 - 2.8e-19 69.2 8.8 0.00044 20.5 0.1 6.0 3 2 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31084.1 - 2.3e-07 29.8 4.6 0.037 12.7 0.2 4.3 3 2 2 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO31084.1 - 5.7e-07 29.6 0.9 0.032 14.1 0.0 3.3 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO31084.1 - 8.2e-05 21.7 0.4 0.76 8.7 0.0 4.3 3 2 3 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO31084.1 - 0.0023 17.3 0.2 0.29 10.4 0.0 2.8 2 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO31084.1 - 0.019 13.5 0.0 0.1 11.1 0.0 2.2 2 1 0 2 2 2 0 Cytochrome D1 heme domain WD40_like PF17005.5 ETO31084.1 - 0.021 14.2 0.0 39 3.4 0.0 3.8 3 1 1 4 4 4 0 WD40-like domain IKI3 PF04762.12 ETO31084.1 - 0.04 11.9 0.0 0.085 10.8 0.0 1.6 1 0 0 1 1 1 0 IKI3 family NLE PF08154.12 ETO31085.1 - 8.1e-11 42.3 0.1 1.7e-10 41.3 0.1 1.5 1 0 0 1 1 1 1 NLE (NUC135) domain DUF1387 PF07139.11 ETO31085.1 - 0.31 10.7 6.8 0.38 10.5 6.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DDHD PF02862.17 ETO31086.1 - 0.046 13.9 3.2 0.062 13.4 3.2 1.3 1 0 0 1 1 1 0 DDHD domain CDC45 PF02724.14 ETO31086.1 - 0.064 11.6 5.1 0.062 11.6 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein MTP18 PF10558.9 ETO31086.1 - 0.078 12.9 1.6 0.27 11.2 1.6 2.0 1 1 0 1 1 1 0 Mitochondrial 18 KDa protein (MTP18) EI24 PF07264.11 ETO31086.1 - 0.24 11.6 0.8 0.38 11.0 0.8 1.2 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) GNAT_acetyltr_2 PF13718.6 ETO31086.1 - 0.28 10.6 3.0 0.49 9.8 3.0 1.3 1 0 0 1 1 1 0 GNAT acetyltransferase 2 Zip PF02535.22 ETO31086.1 - 0.45 9.7 2.7 0.49 9.5 2.7 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO31086.1 - 1.2 7.9 6.5 1.5 7.5 6.5 1.2 1 0 0 1 1 1 0 Presenilin DUF1980 PF09323.10 ETO31086.1 - 5.7 6.8 6.7 12 5.7 6.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) CAP_GLY PF01302.25 ETO31088.1 - 0.058 13.4 0.0 0.15 12.1 0.0 1.6 1 0 0 1 1 1 0 CAP-Gly domain Sigma70_ner PF04546.13 ETO31090.1 - 0.0013 18.6 11.0 0.0087 16.0 11.0 2.5 1 0 0 1 1 1 1 Sigma-70, non-essential region DUF2457 PF10446.9 ETO31090.1 - 0.019 14.2 25.7 0.059 12.5 25.7 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) NOA36 PF06524.12 ETO31090.1 - 0.29 10.4 23.2 1.1 8.5 23.2 1.9 1 0 0 1 1 1 0 NOA36 protein DUF1981 PF09324.10 ETO31090.1 - 1.5 8.8 5.9 2.7 7.9 0.2 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF1981) Apt1 PF10351.9 ETO31091.1 - 0.44 9.3 7.2 0.48 9.2 7.2 1.1 1 0 0 1 1 1 0 Golgi-body localisation protein domain SPX PF03105.19 ETO31091.1 - 0.46 10.4 8.9 0.52 10.2 8.9 1.1 1 0 0 1 1 1 0 SPX domain 7tm_1 PF00001.21 ETO31092.1 - 1.2e-10 41.2 14.8 0.048 13.0 0.1 6.1 1 1 5 6 6 6 5 7 transmembrane receptor (rhodopsin family) BIRC6 PF12356.8 ETO31092.1 - 0.12 11.8 5.0 1.9 7.9 0.1 3.2 3 0 0 3 3 3 0 Baculoviral IAP repeat-containing protein 6 SPRY PF00622.28 ETO31095.1 - 4.2e-27 94.7 0.2 7.5e-27 93.8 0.2 1.4 1 0 0 1 1 1 1 SPRY domain HECT PF00632.25 ETO31097.1 - 3.7e-68 230.3 0.0 4e-66 223.6 0.1 2.3 1 1 1 2 2 2 2 HECT-domain (ubiquitin-transferase) zf-RanBP PF00641.18 ETO31097.1 - 7e-05 22.1 1.6 0.00017 20.8 1.6 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others 2OG-FeII_Oxy_3 PF13640.6 ETO31098.1 - 5e-18 65.8 0.0 1.2e-17 64.6 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 ETO31098.1 - 2.4e-06 28.1 0.0 7.2e-06 26.6 0.0 1.8 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily RNF220 PF15926.5 ETO31100.1 - 0.059 13.0 1.9 0.062 12.9 1.9 1.0 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 Aldolase_II PF00596.21 ETO31101.1 - 1.3e-07 31.8 0.0 1.5e-07 31.5 0.0 1.1 1 0 0 1 1 1 1 Class II Aldolase and Adducin N-terminal domain HAP PF03866.13 ETO31101.1 - 0.025 14.6 0.0 0.03 14.3 0.0 1.1 1 0 0 1 1 1 0 Hydrophobic abundant protein (HAP) HEM4 PF02602.15 ETO31102.1 - 1.1e-16 61.0 0.0 1.3e-16 60.7 0.0 1.0 1 0 0 1 1 1 1 Uroporphyrinogen-III synthase HemD PPC PF04151.15 ETO31103.1 - 0.76 10.9 6.0 6 8.0 0.1 2.5 2 0 0 2 2 2 0 Bacterial pre-peptidase C-terminal domain Secretin_N_2 PF07655.13 ETO31103.1 - 3.7 8.2 15.8 0.055 14.0 7.2 2.1 2 0 0 2 2 2 0 Secretin N-terminal domain MIF4G PF02854.19 ETO31105.1 - 1.5e-24 86.8 6.3 4e-24 85.4 6.3 1.8 1 0 0 1 1 1 1 MIF4G domain GP120 PF00516.18 ETO31105.1 - 0.024 13.3 0.0 0.04 12.5 0.0 1.3 1 0 0 1 1 1 0 Envelope glycoprotein GP120 Methyltransf_11 PF08241.12 ETO31106.1 - 1.7e-11 44.6 0.0 3.1e-11 43.8 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO31106.1 - 2.4e-07 31.4 0.0 5e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO31106.1 - 5.2e-07 29.6 0.0 8.1e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO31106.1 - 5.1e-05 23.1 0.0 8.6e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO31106.1 - 0.0002 20.8 0.0 0.00039 19.8 0.0 1.5 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ETO31106.1 - 0.00023 21.8 0.0 0.00077 20.2 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_29 PF03141.16 ETO31106.1 - 0.028 13.0 0.0 0.04 12.5 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase DUF1869 PF08956.10 ETO31107.1 - 0.0054 16.6 0.0 0.0093 15.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF1869) Methyltr_RsmB-F PF01189.17 ETO31108.1 - 6e-11 42.4 0.0 1.2e-10 41.4 0.0 1.4 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F Amidase PF01425.21 ETO31109.1 - 4.8e-44 151.0 0.4 1.3e-24 87.1 0.6 2.5 2 1 0 2 2 2 2 Amidase Baculo_LEF-2 PF03041.14 ETO31109.1 - 0.025 14.2 0.2 0.038 13.6 0.2 1.2 1 0 0 1 1 1 0 lef-2 DUF588 PF04535.12 ETO31109.1 - 0.13 12.0 0.3 0.5 10.1 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF588) Amidase PF01425.21 ETO31110.1 - 1.9e-10 40.3 0.0 2.1e-10 40.2 0.0 1.0 1 0 0 1 1 1 1 Amidase Mlh1_C PF16413.5 ETO31111.1 - 0.062 12.7 1.0 0.078 12.3 0.3 1.5 1 1 1 2 2 2 0 DNA mismatch repair protein Mlh1 C-terminus FGE-sulfatase PF03781.16 ETO31112.1 - 5.9e-62 209.6 0.8 5.9e-62 209.6 0.8 1.4 2 0 0 2 2 2 1 Sulfatase-modifying factor enzyme 1 Dehydrin PF00257.19 ETO31113.1 - 0.056 14.0 1.3 0.073 13.6 1.3 1.2 1 0 0 1 1 1 0 Dehydrin SR-25 PF10500.9 ETO31113.1 - 0.057 13.0 5.8 0.065 12.8 5.8 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF755 PF05501.11 ETO31113.1 - 0.092 13.0 9.3 0.14 12.4 9.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF755) DUF3878 PF12994.7 ETO31113.1 - 0.15 11.5 0.3 0.19 11.2 0.3 1.0 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3878) IMUP PF15761.5 ETO31113.1 - 0.3 11.8 8.3 0.43 11.3 8.3 1.2 1 0 0 1 1 1 0 Immortalisation up-regulated protein V-set_CD47 PF08204.11 ETO31113.1 - 0.43 10.6 6.2 0.13 12.2 3.4 1.7 1 1 1 2 2 2 0 CD47 immunoglobulin-like domain AF-4 PF05110.13 ETO31113.1 - 0.43 8.6 6.5 0.49 8.4 6.5 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein PT PF04886.12 ETO31114.1 - 1e-13 50.5 178.2 5.1e-08 32.3 21.0 11.0 3 3 6 9 9 9 7 PT repeat WD40 PF00400.32 ETO31115.1 - 6.2e-29 99.6 33.1 4.5e-07 30.5 2.5 7.6 5 2 0 5 5 5 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO31115.1 - 3.3e-06 26.0 8.6 0.16 10.6 1.9 4.8 2 2 2 4 4 4 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO31115.1 - 8.4e-06 26.0 0.7 0.21 11.9 0.0 4.3 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO31115.1 - 0.005 17.5 0.2 0.005 17.5 0.2 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger FapA PF03961.13 ETO31115.1 - 0.0066 15.1 8.5 0.01 14.5 8.5 1.3 1 0 0 1 1 1 1 Flagellar Assembly Protein A DUF4407 PF14362.6 ETO31115.1 - 0.056 12.8 4.9 0.092 12.1 4.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Exonuc_VII_L PF02601.15 ETO31115.1 - 0.069 12.7 6.8 0.1 12.2 6.8 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit LMBR1 PF04791.16 ETO31115.1 - 0.53 9.1 6.9 0.75 8.6 6.9 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein OmpH PF03938.14 ETO31115.1 - 2 8.8 20.1 6.3 7.1 20.1 1.8 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF413 PF04219.12 ETO31115.1 - 2.7 8.1 8.1 2.6 8.1 2.4 2.4 1 1 1 2 2 2 0 Protein of unknown function, DUF Sarcoglycan_2 PF05510.13 ETO31116.1 - 0.042 12.6 4.6 0.045 12.5 4.6 1.0 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon DUF1043 PF06295.12 ETO31116.1 - 0.71 9.9 6.0 0.96 9.5 6.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1043) TMEM214 PF10151.9 ETO31116.1 - 1.1 7.6 8.0 1.2 7.5 8.0 1.0 1 0 0 1 1 1 0 TMEM214, C-terminal, caspase 4 activator UbiA PF01040.18 ETO31117.1 - 2.3e-38 131.9 3.9 2.3e-38 131.9 3.9 1.7 1 1 0 1 1 1 1 UbiA prenyltransferase family WD40 PF00400.32 ETO31118.1 - 4e-38 128.7 30.4 2.3e-06 28.2 1.2 7.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31118.1 - 7.7e-13 48.6 8.6 0.02 15.2 0.1 6.4 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31118.1 - 3.2e-10 39.3 15.7 0.00086 18.1 4.2 4.8 1 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31118.1 - 0.00076 18.9 22.6 0.0076 15.6 1.4 5.5 4 2 3 7 7 7 2 WD40-like domain Peptidase_C14 PF00656.22 ETO31119.1 - 1.5e-14 54.6 1.1 4.3e-14 53.1 1.1 1.7 1 1 0 1 1 1 1 Caspase domain NACHT PF05729.12 ETO31120.1 - 1.6e-05 24.9 0.0 0.006 16.5 0.0 2.6 1 1 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO31120.1 - 0.0011 19.2 0.1 0.011 16.0 0.0 2.6 2 1 1 3 3 3 1 AAA domain ABC_tran PF00005.27 ETO31120.1 - 0.0014 19.2 0.2 0.0061 17.1 0.0 2.2 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 ETO31120.1 - 0.013 16.1 6.0 0.017 15.7 0.3 3.2 2 1 1 3 3 3 0 AAA domain TsaE PF02367.17 ETO31120.1 - 0.025 14.6 0.0 0.094 12.7 0.0 1.9 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_5 PF07728.14 ETO31120.1 - 0.063 13.3 0.0 1.7 8.7 0.0 2.6 2 0 0 2 2 2 0 AAA domain (dynein-related subfamily) TniB PF05621.11 ETO31120.1 - 0.069 12.5 0.0 0.15 11.4 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein RsgA_GTPase PF03193.16 ETO31120.1 - 0.072 13.0 1.7 0.64 9.9 0.0 3.1 3 1 0 4 4 4 0 RsgA GTPase RNA_helicase PF00910.22 ETO31120.1 - 1.7 9.1 6.2 0.67 10.4 0.1 3.5 3 1 0 3 3 3 0 RNA helicase Borrelia_P83 PF05262.11 ETO31123.1 - 0.091 11.2 8.9 0.1 11.1 8.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Plasmodium_Vir PF05795.11 ETO31123.1 - 0.55 9.6 3.5 0.6 9.5 3.5 1.1 1 0 0 1 1 1 0 Plasmodium vivax Vir protein CDC27 PF09507.10 ETO31123.1 - 0.7 9.2 12.6 0.98 8.7 12.6 1.2 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 MscS_TM PF12794.7 ETO31123.1 - 3.9 6.2 8.7 5.4 5.8 8.7 1.1 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Presenilin PF01080.17 ETO31123.1 - 4 6.1 6.8 4.3 6.0 6.8 1.1 1 0 0 1 1 1 0 Presenilin zf-RING_5 PF14634.6 ETO31127.1 - 7.5e-06 25.8 3.0 7.5e-06 25.8 3.0 2.4 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_3 PF13920.6 ETO31127.1 - 4.5e-05 23.2 2.3 0.00012 21.8 2.3 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO31127.1 - 0.00017 21.5 5.8 0.00023 21.1 4.4 2.1 2 0 0 2 2 2 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO31127.1 - 0.00041 20.1 2.3 0.00041 20.1 2.3 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO31127.1 - 0.0028 17.4 3.0 0.0028 17.4 3.0 2.2 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO31127.1 - 0.003 17.9 2.9 0.003 17.9 2.9 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_4 PF15227.6 ETO31127.1 - 0.052 13.7 2.4 0.14 12.4 2.4 1.8 1 0 0 1 1 1 0 zinc finger of C3HC4-type, RING zf-RING_11 PF17123.5 ETO31127.1 - 0.14 11.9 4.4 0.19 11.5 2.6 2.2 2 0 0 2 2 2 0 RING-like zinc finger Prok-RING_4 PF14447.6 ETO31127.1 - 0.2 11.6 3.4 1.1 9.2 3.5 2.1 1 1 1 2 2 2 0 Prokaryotic RING finger family 4 DUF1676 PF07898.13 ETO31128.1 - 0.046 13.8 0.4 0.097 12.7 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1676) DUF4640 PF15480.6 ETO31130.1 - 0.14 11.8 0.3 0.19 11.5 0.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4640) ATPase PF06745.13 ETO31131.1 - 0.044 13.1 0.2 0.045 13.1 0.2 1.0 1 0 0 1 1 1 0 KaiC PPR_3 PF13812.6 ETO31133.1 - 0.07 13.2 0.7 0.15 12.1 0.2 1.8 2 0 0 2 2 2 0 Pentatricopeptide repeat domain DUF2701 PF10857.8 ETO31134.1 - 0.076 13.1 0.3 0.13 12.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2701) Cbl_N3 PF02762.14 ETO31135.1 - 0.013 15.3 0.0 0.023 14.5 0.0 1.3 1 0 0 1 1 1 0 CBL proto-oncogene N-terminus, SH2-like domain Fe-S_assembly PF04384.13 ETO31135.1 - 0.033 14.8 0.1 0.068 13.8 0.1 1.6 1 1 0 1 1 1 0 Iron-sulphur cluster assembly CDC45 PF02724.14 ETO31136.1 - 0.043 12.1 11.4 0.041 12.2 11.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Sin_N PF04801.13 ETO31136.1 - 0.14 11.3 9.7 0.15 11.2 9.7 1.1 1 0 0 1 1 1 0 Sin-like protein conserved region RNA_polI_A34 PF08208.11 ETO31136.1 - 0.4 10.7 20.3 0.57 10.2 20.3 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 Cellulose_synt PF03552.14 ETO31136.1 - 0.96 7.9 6.6 1.2 7.5 6.6 1.0 1 0 0 1 1 1 0 Cellulose synthase Presenilin PF01080.17 ETO31136.1 - 1.2 7.9 10.9 1.2 7.8 10.9 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO31136.1 - 1.8 7.5 5.9 2.1 7.2 5.9 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO31136.1 - 2.1 7.0 13.4 2.5 6.8 13.4 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SR-25 PF10500.9 ETO31136.1 - 2.3 7.8 27.6 0.95 9.0 9.6 2.2 1 1 1 2 2 2 0 Nuclear RNA-splicing-associated protein Nop14 PF04147.12 ETO31136.1 - 2.4 6.2 21.5 4.3 5.4 20.1 1.8 2 0 0 2 2 2 0 Nop14-like family SLC12 PF03522.15 ETO31136.1 - 2.6 7.0 10.6 3 6.8 10.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 LAP1C PF05609.12 ETO31136.1 - 3.5 6.6 13.2 3.9 6.4 13.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Neur_chan_memb PF02932.16 ETO31136.1 - 4.9 7.1 6.3 6 6.9 6.3 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Tim54 PF11711.8 ETO31136.1 - 9.5 4.9 12.1 13 4.4 12.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 WW PF00397.26 ETO31138.1 - 3.2e-11 43.1 3.6 6.5e-11 42.1 3.6 1.6 1 0 0 1 1 1 1 WW domain XPG_I PF00867.18 ETO31139.1 - 0.033 14.5 0.9 0.14 12.5 0.0 2.5 2 0 0 2 2 2 0 XPG I-region DUF3439 PF11921.8 ETO31139.1 - 2.5 8.1 36.3 0.21 11.5 14.0 3.3 3 1 1 4 4 4 0 Domain of unknown function (DUF3439) AMMECR1 PF01871.17 ETO31141.1 - 0.0039 16.8 0.0 0.0061 16.2 0.0 1.4 1 0 0 1 1 1 1 AMMECR1 Mito_carr PF00153.27 ETO31142.1 - 3e-33 113.6 0.2 1.2e-17 63.6 0.1 2.3 2 0 0 2 2 2 2 Mitochondrial carrier protein Folate_carrier PF01770.18 ETO31143.1 - 3.2 6.4 4.0 4.6 5.9 4.0 1.3 1 0 0 1 1 1 0 Reduced folate carrier 4HBT_2 PF13279.6 ETO31146.1 - 1e-20 74.5 0.1 1.3e-20 74.1 0.1 1.2 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 ETO31146.1 - 3.1e-05 24.2 0.0 7.4e-05 23.0 0.0 1.6 1 0 0 1 1 1 1 Thioesterase superfamily DHC_N2 PF08393.13 ETO31148.1 - 1.5e-24 86.9 1.3 1.5e-24 86.9 1.3 2.8 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 2 ELH PF02323.15 ETO31148.1 - 0.11 11.9 4.5 0.18 11.1 4.5 1.3 1 0 0 1 1 1 0 Egg-laying hormone precursor GP24_25 PF17388.2 ETO31148.1 - 0.21 11.6 0.0 0.21 11.6 0.0 2.6 3 0 0 3 3 3 0 Tail assembly gene products 24 & 25 NOA36 PF06524.12 ETO31148.1 - 3.7 6.8 13.5 0.52 9.6 9.3 1.7 2 0 0 2 2 2 0 NOA36 protein DHC_N2 PF08393.13 ETO31149.1 - 1.7e-89 300.7 9.2 1.6e-64 218.5 1.7 2.9 2 1 0 2 2 2 2 Dynein heavy chain, N-terminal region 2 AAA_6 PF12774.7 ETO31150.1 - 1.4e-125 418.6 3.4 3.9e-116 387.6 1.0 2.0 2 0 0 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_5 PF07728.14 ETO31150.1 - 0.033 14.2 0.0 0.14 12.1 0.0 2.1 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) Kelch_4 PF13418.6 ETO31151.1 - 0.00011 22.1 0.2 7.9 6.6 0.0 4.2 4 0 0 4 4 4 3 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO31151.1 - 0.033 14.2 0.7 2 8.5 0.0 3.5 4 0 0 4 4 4 0 Kelch motif DUF2817 PF10994.8 ETO31154.1 - 3.3e-37 128.7 0.5 1.7e-34 119.8 0.5 3.2 1 1 0 1 1 1 1 Protein of unknown function (DUF2817) DUF957 PF06117.11 ETO31154.1 - 0.12 11.9 0.3 0.32 10.6 0.3 1.7 1 0 0 1 1 1 0 Enterobacterial protein of unknown function (DUF957) B56 PF01603.20 ETO31155.1 - 0.2 10.6 0.2 0.2 10.6 0.2 2.0 3 0 0 3 3 3 0 Protein phosphatase 2A regulatory B subunit (B56 family) Macoilin PF09726.9 ETO31155.1 - 0.2 10.2 7.9 0.21 10.1 7.9 1.0 1 0 0 1 1 1 0 Macoilin family PGA2 PF07543.12 ETO31155.1 - 1.6 8.7 8.0 2.2 8.3 8.0 1.2 1 0 0 1 1 1 0 Protein trafficking PGA2 zf-UBR PF02207.20 ETO31156.1 - 0.18 12.0 1.1 0.64 10.2 1.1 2.0 1 0 0 1 1 1 0 Putative zinc finger in N-recognin (UBR box) Sec7_N PF12783.7 ETO31157.1 - 3.3e-05 23.8 4.2 0.00012 22.0 2.4 2.3 2 1 0 2 2 2 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Sec7 PF01369.20 ETO31158.1 - 5.6e-36 123.9 0.1 1e-35 123.1 0.1 1.4 1 0 0 1 1 1 1 Sec7 domain Ank_2 PF12796.7 ETO31160.1 - 4.1e-06 27.3 0.4 0.0048 17.5 0.1 2.4 2 1 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO31160.1 - 0.0037 17.8 0.1 0.03 14.9 0.0 2.3 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO31160.1 - 0.0058 16.9 0.6 0.017 15.5 0.1 2.1 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO31160.1 - 0.035 14.6 0.1 0.1 13.1 0.0 1.9 2 1 0 2 2 2 0 Ankyrin repeat Ank_3 PF13606.6 ETO31160.1 - 0.065 13.8 0.0 8.8 7.3 0.0 3.1 3 0 0 3 3 3 0 Ankyrin repeat HELP PF03451.14 ETO31162.1 - 2e-05 24.3 0.0 5.4e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 HELP motif GLEYA PF10528.9 ETO31163.1 - 0.087 13.3 0.2 17 6.0 0.0 2.4 2 0 0 2 2 2 0 GLEYA domain ANAPC4_WD40 PF12894.7 ETO31164.1 - 0.0027 17.9 0.0 0.073 13.4 0.0 2.9 2 1 2 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO31164.1 - 0.32 12.0 3.4 7.7 7.6 0.1 4.1 5 0 0 5 5 5 0 WD domain, G-beta repeat Thioredoxin PF00085.20 ETO31165.1 - 5.3e-46 154.8 4.4 3.8e-22 78.2 0.0 3.7 4 0 0 4 4 4 2 Thioredoxin Thioredoxin_6 PF13848.6 ETO31165.1 - 1.8e-23 83.4 8.9 2.2e-17 63.6 1.2 3.8 3 1 1 4 4 4 3 Thioredoxin-like domain Thioredoxin_2 PF13098.6 ETO31165.1 - 5.4e-14 52.6 4.6 4.8e-09 36.7 0.1 3.2 3 1 0 3 3 2 2 Thioredoxin-like domain Thioredoxin_8 PF13905.6 ETO31165.1 - 1e-12 48.2 3.9 5.7e-06 26.6 0.1 4.5 2 2 2 4 4 4 2 Thioredoxin-like Thioredoxin_7 PF13899.6 ETO31165.1 - 1e-10 41.6 0.4 9.2e-05 22.6 0.1 3.0 2 1 0 2 2 2 2 Thioredoxin-like OST3_OST6 PF04756.13 ETO31165.1 - 3.8e-10 39.6 3.8 8.2e-06 25.4 0.2 2.4 2 0 0 2 2 2 2 OST3 / OST6 family, transporter family AhpC-TSA PF00578.21 ETO31165.1 - 1.1e-07 31.8 1.3 2.3e-05 24.3 0.1 2.9 2 1 0 2 2 2 1 AhpC/TSA family ERp29_N PF07912.13 ETO31165.1 - 1.4e-07 31.7 4.8 1.3e-05 25.4 0.2 3.4 3 1 0 3 3 3 2 ERp29, N-terminal domain Thioredox_DsbH PF03190.15 ETO31165.1 - 0.00014 21.9 0.1 0.00028 20.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function, DUF255 Redoxin PF08534.10 ETO31165.1 - 0.00094 18.9 0.2 0.0053 16.5 0.0 2.1 2 0 0 2 2 2 1 Redoxin HyaE PF07449.11 ETO31165.1 - 0.007 16.3 0.0 2.2 8.3 0.0 2.6 2 0 0 2 2 2 1 Hydrogenase-1 expression protein HyaE TraF PF13728.6 ETO31165.1 - 0.019 14.8 0.1 5.3 6.8 0.0 2.8 3 0 0 3 3 3 0 F plasmid transfer operon protein Thioredoxin_9 PF14595.6 ETO31165.1 - 0.04 13.7 0.0 0.31 10.8 0.0 2.2 2 0 0 2 2 2 0 Thioredoxin Glutaredoxin PF00462.24 ETO31165.1 - 0.7 10.2 3.8 9.6 6.5 0.0 3.5 3 1 0 3 3 3 0 Glutaredoxin Baculo_PEP_C PF04513.12 ETO31166.1 - 0.0041 17.2 10.9 0.01 15.9 10.9 1.6 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 ETO31166.1 - 0.0051 16.7 4.5 0.0071 16.2 4.5 1.2 1 0 0 1 1 1 1 Apolipoprotein A1/A4/E domain HOOK PF05622.12 ETO31166.1 - 0.008 14.4 10.7 0.0093 14.2 10.7 1.0 1 0 0 1 1 1 1 HOOK protein CENP-K PF11802.8 ETO31166.1 - 0.012 15.2 11.1 0.015 14.9 10.9 1.2 1 1 0 1 1 1 0 Centromere-associated protein K TMF_DNA_bd PF12329.8 ETO31166.1 - 0.013 15.5 9.2 0.013 15.5 9.2 2.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 DNA binding DUF3584 PF12128.8 ETO31166.1 - 0.017 12.7 8.9 0.022 12.3 8.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Zw10 PF06248.13 ETO31166.1 - 0.028 13.0 7.9 0.035 12.7 7.9 1.1 1 0 0 1 1 1 0 Centromere/kinetochore Zw10 Spc7 PF08317.11 ETO31166.1 - 0.041 12.8 11.9 0.0092 14.9 7.2 1.5 1 1 0 1 1 1 0 Spc7 kinetochore protein SpoOE-like PF09388.10 ETO31166.1 - 0.052 13.5 2.3 2.1 8.3 0.1 3.1 3 0 0 3 3 3 0 Spo0E like sporulation regulatory protein TMPIT PF07851.13 ETO31166.1 - 0.061 12.6 6.5 0.079 12.2 6.5 1.3 1 0 0 1 1 1 0 TMPIT-like protein Golgin_A5 PF09787.9 ETO31166.1 - 0.064 12.7 11.2 0.086 12.3 11.2 1.1 1 0 0 1 1 1 0 Golgin subfamily A member 5 HAP1_N PF04849.13 ETO31166.1 - 0.084 12.1 9.2 0.095 11.9 9.2 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region FliJ PF02050.16 ETO31166.1 - 0.086 13.1 7.9 0.23 11.7 7.9 1.7 1 1 0 1 1 1 0 Flagellar FliJ protein UVR PF02151.19 ETO31166.1 - 0.095 12.5 3.9 12 5.8 0.2 3.5 3 0 0 3 3 3 0 UvrB/uvrC motif Atg14 PF10186.9 ETO31166.1 - 0.12 11.5 9.5 0.15 11.1 9.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Nup88 PF10168.9 ETO31166.1 - 0.13 10.1 9.2 0.15 9.9 9.2 1.0 1 0 0 1 1 1 0 Nuclear pore component DUF1732 PF08340.11 ETO31166.1 - 0.14 12.1 8.6 1.2 9.1 8.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF1732) Vps51 PF08700.11 ETO31166.1 - 0.16 12.1 8.7 0.18 11.9 4.5 2.3 1 1 1 2 2 2 0 Vps51/Vps67 SpecificRecomb PF10136.9 ETO31166.1 - 0.18 10.1 1.1 0.19 10.0 1.1 1.1 1 0 0 1 1 1 0 Site-specific recombinase IFT57 PF10498.9 ETO31166.1 - 0.19 10.7 12.4 0.27 10.2 12.4 1.2 1 0 0 1 1 1 0 Intra-flagellar transport protein 57 LMBR1 PF04791.16 ETO31166.1 - 0.2 10.5 5.2 0.22 10.4 5.2 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF4407 PF14362.6 ETO31166.1 - 0.21 10.9 4.4 0.25 10.7 4.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YtxH PF12732.7 ETO31166.1 - 0.22 12.1 4.6 0.87 10.2 4.6 2.1 1 1 0 1 1 1 0 YtxH-like protein TPR_MLP1_2 PF07926.12 ETO31166.1 - 0.23 11.5 10.4 2.1 8.4 10.3 2.2 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein TolA_bind_tri PF16331.5 ETO31166.1 - 0.24 11.5 10.1 1 9.5 4.6 2.9 1 1 2 3 3 3 0 TolA binding protein trimerisation AIP3 PF03915.13 ETO31166.1 - 0.38 9.8 13.0 0.56 9.2 13.0 1.3 1 1 0 1 1 1 0 Actin interacting protein 3 DUF724 PF05266.14 ETO31166.1 - 0.38 10.5 11.3 0.66 9.8 11.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF724) DUF1664 PF07889.12 ETO31166.1 - 0.44 10.6 12.6 1.1 9.3 7.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 ETO31166.1 - 0.47 10.7 12.2 0.11 12.7 6.1 2.0 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Seryl_tRNA_N PF02403.22 ETO31166.1 - 0.5 10.6 14.6 0.34 11.2 5.8 2.1 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain COG5 PF10392.9 ETO31166.1 - 0.54 10.4 7.8 5.4 7.2 3.6 2.1 1 1 1 2 2 2 0 Golgi transport complex subunit 5 LPP PF04728.13 ETO31166.1 - 0.55 10.7 12.2 2.2 8.7 0.4 4.0 2 1 2 4 4 4 0 Lipoprotein leucine-zipper bZIP_1 PF00170.21 ETO31166.1 - 0.56 10.3 10.4 0.1 12.7 1.6 3.1 2 1 0 2 2 2 0 bZIP transcription factor PDDEXK_6 PF04720.12 ETO31166.1 - 0.68 9.8 4.8 0.89 9.5 4.8 1.2 1 0 0 1 1 1 0 PDDEXK-like family of unknown function Matrilin_ccoil PF10393.9 ETO31166.1 - 0.75 9.7 4.4 2.9 7.8 0.9 2.8 2 1 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin Fib_alpha PF08702.10 ETO31166.1 - 0.85 9.8 14.7 2.2 8.4 14.7 1.8 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Sec34 PF04136.15 ETO31166.1 - 0.88 9.4 9.4 0.99 9.3 3.9 2.1 1 1 0 1 1 1 0 Sec34-like family DUF1690 PF07956.11 ETO31166.1 - 1.1 9.7 13.2 33 4.9 13.2 2.1 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) Prominin PF05478.11 ETO31166.1 - 1.1 7.1 9.3 1.2 7.0 9.3 1.1 1 0 0 1 1 1 0 Prominin DUF948 PF06103.11 ETO31166.1 - 1.2 9.5 7.9 16 5.8 7.9 2.3 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF948) DUF1515 PF07439.11 ETO31166.1 - 1.3 9.1 3.8 1.2 9.2 1.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) DUF5082 PF16888.5 ETO31166.1 - 1.3 9.4 15.5 4.6 7.5 15.5 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) ACCA PF03255.14 ETO31166.1 - 1.7 8.5 8.6 2.2 8.2 2.5 2.4 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit Spc24 PF08286.11 ETO31166.1 - 2.1 8.6 12.9 4.5 7.6 5.8 2.3 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 FlaC_arch PF05377.11 ETO31166.1 - 2.1 8.8 17.9 2.4 8.6 1.9 3.2 3 0 0 3 3 3 0 Flagella accessory protein C (FlaC) DUF2203 PF09969.9 ETO31166.1 - 2.5 8.9 7.4 4.2 8.1 2.0 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) HIP1_clath_bdg PF16515.5 ETO31166.1 - 2.6 8.7 11.1 3.6 8.3 8.7 2.0 1 1 1 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Tropomyosin_1 PF12718.7 ETO31166.1 - 2.7 8.1 15.3 26 4.9 15.3 2.0 1 1 0 1 1 1 0 Tropomyosin like ZapB PF06005.12 ETO31166.1 - 2.7 8.5 15.4 1.5e+02 2.9 15.4 2.6 1 1 0 1 1 1 0 Cell division protein ZapB YabA PF06156.13 ETO31166.1 - 3.5 8.3 12.2 3.6 8.3 3.8 2.3 1 1 1 2 2 2 0 Initiation control protein YabA UPF0242 PF06785.11 ETO31166.1 - 3.8 7.6 13.4 6.7 6.8 13.4 1.3 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Lectin_N PF03954.14 ETO31166.1 - 4.1 7.2 10.2 8.8 6.1 2.7 2.7 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DUF4200 PF13863.6 ETO31166.1 - 5.2 7.5 13.0 1.3 9.4 4.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) Snapin_Pallidin PF14712.6 ETO31166.1 - 7.2 7.1 13.6 3 8.3 6.0 2.2 1 1 1 2 2 2 0 Snapin/Pallidin DUF16 PF01519.16 ETO31166.1 - 9.5 6.8 15.4 34 5.0 6.5 2.4 1 1 1 2 2 2 0 Protein of unknown function DUF16 ATG16 PF08614.11 ETO31167.1 - 0.27 11.4 60.0 0.043 14.1 24.7 2.6 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) Spore_Cse60 PF10957.8 ETO31167.1 - 0.82 9.7 7.6 0.086 12.9 0.6 2.9 3 0 0 3 3 3 0 Sporulation protein Cse60 DUF1729 PF08354.10 ETO31167.1 - 1.5 7.6 13.8 0.92 8.3 11.7 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF1729) PA26 PF04636.13 ETO31169.1 - 1.1e-29 103.7 0.1 1.3e-29 103.4 0.1 1.0 1 0 0 1 1 1 1 PA26 p53-induced protein (sestrin) RSN1_TM PF13967.6 ETO31170.1 - 0.1 12.3 0.0 0.24 11.2 0.0 1.6 1 0 0 1 1 1 0 Late exocytosis, associated with Golgi transport SLC12 PF03522.15 ETO31170.1 - 0.57 9.1 13.1 1.8 7.5 7.5 2.2 2 0 0 2 2 2 0 Solute carrier family 12 Mucin PF01456.17 ETO31170.1 - 0.61 10.1 3.7 0.23 11.5 0.8 1.8 2 0 0 2 2 2 0 Mucin-like glycoprotein ETRAMP PF09716.10 ETO31170.1 - 1.3 9.1 4.5 0.3 11.2 0.3 2.1 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Peptidase_M48 PF01435.18 ETO31171.1 - 2.5e-36 125.3 0.0 3.3e-36 124.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M48 Peptidase_M56 PF05569.11 ETO31171.1 - 0.0055 15.9 0.3 0.0083 15.4 0.3 1.2 1 0 0 1 1 1 1 BlaR1 peptidase M56 SprT-like PF10263.9 ETO31171.1 - 0.044 13.6 0.2 0.069 13.0 0.2 1.3 1 0 0 1 1 1 0 SprT-like family DUF2268 PF10026.9 ETO31171.1 - 0.071 12.7 0.1 0.1 12.1 0.1 1.2 1 0 0 1 1 1 0 Predicted Zn-dependent protease (DUF2268) UQ_con PF00179.26 ETO31173.1 - 6.9e-35 119.7 1.4 3e-23 82.0 0.1 3.1 3 0 0 3 3 3 3 Ubiquitin-conjugating enzyme Methyltransf_25 PF13649.6 ETO31174.1 - 1.4e-11 45.0 0.0 1e-10 42.2 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO31174.1 - 3.5e-11 43.1 0.1 1.7e-10 40.9 0.0 2.1 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO31174.1 - 1.4e-10 41.7 0.0 1.9e-09 38.0 0.0 2.3 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO31174.1 - 9.9e-10 39.1 0.0 7.1e-09 36.3 0.0 2.2 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO31174.1 - 2.8e-07 30.5 0.0 6.2e-07 29.4 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO31174.1 - 0.0044 17.0 0.5 0.009 16.0 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_4 PF02390.17 ETO31174.1 - 0.022 14.2 0.1 0.073 12.5 0.0 1.8 2 0 0 2 2 2 0 Putative methyltransferase MTS PF05175.14 ETO31174.1 - 0.03 13.9 0.0 0.061 12.9 0.0 1.5 1 0 0 1 1 1 0 Methyltransferase small domain K1377 PF15352.6 ETO31174.1 - 0.031 12.6 0.1 0.043 12.1 0.1 1.1 1 0 0 1 1 1 0 Susceptibility to monomelic amyotrophy NodS PF05401.11 ETO31174.1 - 0.033 13.8 0.0 0.1 12.2 0.0 1.7 1 1 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_18 PF12847.7 ETO31174.1 - 0.056 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Methyltransferase domain PCMT PF01135.19 ETO31174.1 - 0.11 12.2 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TRAPPC-Trs85 PF12739.7 ETO31175.1 - 0.07 12.1 3.8 0.071 12.1 3.8 1.1 1 0 0 1 1 1 0 ER-Golgi trafficking TRAPP I complex 85 kDa subunit Zip PF02535.22 ETO31175.1 - 7.6 5.6 5.0 8 5.6 5.0 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO31175.1 - 9.7 4.8 12.2 10 4.7 12.2 1.2 1 0 0 1 1 1 0 Presenilin Ank_3 PF13606.6 ETO31176.1 - 7e-16 56.7 4.6 0.00041 20.6 0.2 4.5 4 0 0 4 4 4 4 Ankyrin repeat Ank_2 PF12796.7 ETO31176.1 - 1.7e-15 57.3 0.8 0.0002 21.9 0.1 3.2 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO31176.1 - 1.2e-13 51.0 4.0 0.00099 19.4 0.0 4.4 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO31176.1 - 1.3e-13 50.7 5.7 0.00062 20.1 0.3 4.3 4 0 0 4 4 4 3 Ankyrin repeat Ank_4 PF13637.6 ETO31176.1 - 2.6e-13 50.2 2.6 0.00093 19.7 0.1 4.3 3 1 1 4 4 4 3 Ankyrin repeats (many copies) WD40 PF00400.32 ETO31178.1 - 1.5e-21 76.2 10.4 8.4e-09 35.9 0.9 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31178.1 - 8.7e-05 22.8 0.0 0.32 11.3 0.0 3.6 2 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31178.1 - 0.0011 17.8 0.2 1.9 7.1 0.0 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF4407 PF14362.6 ETO31178.1 - 2.5 7.4 14.4 3.3 7.0 14.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4241 PF14025.6 ETO31178.1 - 6.2 7.1 8.8 0.17 12.1 0.3 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF4241) MAD PF05557.13 ETO31178.1 - 7.1 4.9 28.6 8.5 4.6 28.6 1.0 1 0 0 1 1 1 0 Mitotic checkpoint protein Kelch_1 PF01344.25 ETO31180.1 - 0.014 14.9 3.8 0.14 11.7 1.4 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO31180.1 - 0.052 13.6 4.1 1.2 9.2 0.6 3.7 3 1 1 4 4 4 0 Kelch motif SPRY PF00622.28 ETO31181.1 - 0.093 12.9 0.0 0.23 11.6 0.0 1.7 1 0 0 1 1 1 0 SPRY domain ATG16 PF08614.11 ETO31182.1 - 0.00052 20.3 28.3 0.00052 20.3 28.3 5.3 3 2 1 4 4 4 2 Autophagy protein 16 (ATG16) GAS PF13851.6 ETO31182.1 - 1.7 8.0 106.2 0.26 10.6 18.9 6.7 3 1 4 7 7 7 0 Growth-arrest specific micro-tubule binding DUF1515 PF07439.11 ETO31182.1 - 4.5 7.3 21.6 11 6.1 11.6 4.0 3 2 0 3 3 3 0 Protein of unknown function (DUF1515) Fib_alpha PF08702.10 ETO31183.1 - 0.00032 20.9 12.1 0.00049 20.3 12.1 1.2 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family TRIQK PF15168.6 ETO31183.1 - 0.0017 18.2 0.2 0.0069 16.3 0.2 1.9 2 0 0 2 2 2 1 Triple QxxK/R motif-containing protein family TMF_DNA_bd PF12329.8 ETO31183.1 - 0.0084 16.1 8.9 0.0084 16.1 8.9 2.8 1 1 2 3 3 3 1 TATA element modulatory factor 1 DNA binding Spc7 PF08317.11 ETO31183.1 - 0.012 14.5 17.8 0.018 14.0 17.8 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein FUSC PF04632.12 ETO31183.1 - 0.025 13.1 2.4 0.029 12.9 2.4 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family FliJ PF02050.16 ETO31183.1 - 0.032 14.5 19.3 0.067 13.4 19.3 1.6 1 0 0 1 1 1 0 Flagellar FliJ protein CENP-F_leu_zip PF10473.9 ETO31183.1 - 0.057 13.4 17.8 0.088 12.8 17.8 1.2 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF812 PF05667.11 ETO31183.1 - 0.069 12.0 15.5 0.083 11.8 15.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DivIC PF04977.15 ETO31183.1 - 0.088 12.6 16.3 0.053 13.3 4.3 2.9 1 1 1 2 2 2 0 Septum formation initiator DUF1027 PF06265.11 ETO31183.1 - 0.12 12.4 0.1 0.29 11.2 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1027) RAMP4 PF06624.12 ETO31183.1 - 0.17 12.0 0.1 0.17 12.0 0.1 2.9 2 1 1 3 3 3 0 Ribosome associated membrane protein RAMP4 DUF2721 PF11026.8 ETO31183.1 - 0.18 11.7 0.6 0.98 9.3 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2721) SpoIISA_toxin PF14171.6 ETO31183.1 - 0.19 11.4 4.2 0.31 10.7 4.0 1.4 1 1 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system BLOC1_2 PF10046.9 ETO31183.1 - 0.19 12.0 15.4 0.12 12.6 7.8 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 PDZ_3 PF17815.1 ETO31183.1 - 0.23 11.3 4.8 0.38 10.6 4.8 1.4 1 1 0 1 1 1 0 PDZ domain Phage_GPO PF05929.11 ETO31183.1 - 0.27 10.8 9.6 0.41 10.2 9.6 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase HIP1_clath_bdg PF16515.5 ETO31183.1 - 0.3 11.7 18.6 0.22 12.2 6.5 2.4 1 1 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Exonuc_VII_L PF02601.15 ETO31183.1 - 0.35 10.4 9.9 0.42 10.1 9.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit GAS PF13851.6 ETO31183.1 - 0.38 10.1 20.9 0.97 8.7 3.0 2.2 1 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding HIT PF01230.23 ETO31183.1 - 0.43 11.4 1.9 4.1 8.2 1.9 2.1 1 1 0 1 1 1 0 HIT domain Atg14 PF10186.9 ETO31183.1 - 0.58 9.2 16.1 0.9 8.6 15.9 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 EMP24_GP25L PF01105.24 ETO31183.1 - 1.1 9.2 9.6 3.3 7.6 9.6 1.8 1 1 0 1 1 1 0 emp24/gp25L/p24 family/GOLD DUF3837 PF12939.7 ETO31183.1 - 1.6 9.1 9.0 6 7.3 1.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF3837) DUF4407 PF14362.6 ETO31183.1 - 1.8 7.8 13.0 2.9 7.2 13.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TPR_MLP1_2 PF07926.12 ETO31183.1 - 2.6 8.1 24.5 2.5e+02 1.7 24.5 2.4 1 1 0 1 1 1 0 TPR/MLP1/MLP2-like protein BRE1 PF08647.11 ETO31183.1 - 2.8 8.1 21.3 0.77 9.9 11.6 2.4 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase DUF3573 PF12097.8 ETO31183.1 - 4.6 6.0 6.0 6.1 5.6 6.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) PRKG1_interact PF15898.5 ETO31183.1 - 5.9 7.9 18.8 0.44 11.5 12.9 2.0 2 1 0 2 2 1 0 cGMP-dependent protein kinase interacting domain DUF3972 PF13118.6 ETO31183.1 - 7.1 7.1 14.6 2.3 8.7 5.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF3972) TMPIT PF07851.13 ETO31183.1 - 8 5.6 14.1 22 4.1 14.1 1.7 1 1 0 1 1 1 0 TMPIT-like protein Cnn_1N PF07989.11 ETO31183.1 - 8.3 6.6 15.2 4.7 7.4 6.4 2.9 1 1 2 3 3 3 0 Centrosomin N-terminal motif 1 DUF1664 PF07889.12 ETO31183.1 - 8.8 6.4 11.6 2.5 8.2 4.9 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) Orf78 PF06024.12 ETO31183.1 - 9 6.7 8.8 1.2e+02 3.0 8.8 2.5 1 1 0 1 1 1 0 Orf78 (ac78) CC2-LZ PF16516.5 ETO31183.1 - 9.4 6.7 19.1 15 6.0 7.6 2.4 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PCRF PF03462.18 ETO31183.1 - 9.4 6.0 13.2 14 5.5 2.3 1.6 1 1 1 2 2 2 0 PCRF domain Pox_polyA_pol_N PF12630.7 ETO31184.1 - 0.16 12.3 10.0 0.18 12.2 0.3 3.1 2 1 1 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain Pentapeptide PF00805.22 ETO31185.1 - 5.5e-08 32.3 4.6 4.1e-07 29.5 4.4 2.0 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_3 PF13576.6 ETO31185.1 - 0.00069 19.7 0.1 0.0011 19.0 0.1 1.3 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 ETO31185.1 - 0.0011 19.1 1.7 0.066 13.4 1.2 2.3 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Tubulin PF00091.25 ETO31186.1 - 2e-60 204.4 0.2 3e-60 203.8 0.2 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO31186.1 - 4.1e-28 98.1 0.0 7e-28 97.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Kelch_6 PF13964.6 ETO31187.1 - 0.0001 22.4 0.4 0.079 13.3 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO31187.1 - 0.0013 18.3 0.1 0.48 10.1 0.0 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO31187.1 - 0.0034 17.4 0.0 0.0034 17.4 0.0 1.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO31187.1 - 0.032 14.2 0.1 1.5 8.9 0.1 2.3 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO31188.1 - 2.7e-60 198.9 19.2 2.4e-10 40.8 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31188.1 - 3.4e-28 97.8 4.6 0.00012 22.2 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31188.1 - 3.9e-16 58.9 0.2 0.036 13.0 0.0 6.0 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO31188.1 - 4.2e-16 59.1 0.4 4e-05 23.1 0.1 4.0 2 2 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO31188.1 - 4.5e-13 48.7 4.6 0.0093 14.7 0.0 5.6 1 1 5 6 6 6 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO31188.1 - 8.8e-08 31.3 8.0 0.15 10.8 0.4 5.2 1 1 4 5 5 5 5 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO31188.1 - 2.8e-07 29.4 0.1 0.00015 20.4 0.1 2.4 2 1 0 2 2 2 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO31188.1 - 3e-05 22.9 0.1 0.52 9.0 0.0 3.8 2 1 2 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO31188.1 - 6.4e-05 22.8 5.2 5.3 7.1 0.0 5.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO31188.1 - 0.0018 17.9 0.1 0.015 14.8 0.1 2.4 1 1 0 1 1 1 1 PQQ-like domain nos_propeller PF18764.1 ETO31188.1 - 0.0067 16.3 0.0 28 4.7 0.0 4.3 6 0 0 6 6 6 0 Nitrous oxide reductase propeller repeat DUF5474 PF17568.2 ETO31188.1 - 0.0073 16.3 0.8 1.2 9.3 0.0 4.0 3 1 2 5 5 5 1 Family of unknown function (DUF5474) VID27 PF08553.10 ETO31188.1 - 0.011 14.8 0.0 1.1 8.2 0.0 2.8 1 1 2 3 3 3 0 VID27 C-terminal WD40-like domain LRR_11 PF18831.1 ETO31188.1 - 0.082 12.5 0.1 0.16 11.5 0.1 1.4 1 0 0 1 1 1 0 Leucine-rich repeat WD40 PF00400.32 ETO31189.1 - 9.5e-22 76.9 15.0 2.1e-06 28.4 0.1 6.1 5 3 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31189.1 - 7e-09 35.9 0.2 0.0084 16.4 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31189.1 - 0.0001 21.1 0.4 0.19 10.3 0.1 2.9 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31189.1 - 0.00037 19.9 1.8 0.053 12.8 0.2 3.0 2 1 1 3 3 3 2 WD40-like domain CAP_GLY PF01302.25 ETO31190.1 - 7e-126 410.4 45.6 3.8e-18 65.3 1.1 10.0 10 0 0 10 10 10 9 CAP-Gly domain Hint_2 PF13403.6 ETO31190.1 - 0.00047 20.5 1.2 19 5.6 0.0 5.1 6 0 0 6 6 6 2 Hint domain YajC PF02699.15 ETO31190.1 - 0.0029 17.4 19.8 5.5 6.9 0.4 7.8 8 0 0 8 8 8 3 Preprotein translocase subunit HtaA PF04213.13 ETO31190.1 - 0.22 12.0 3.0 1.1 9.8 0.2 3.3 4 0 0 4 4 4 0 Htaa CAP_GLY PF01302.25 ETO31191.1 - 1.8e-82 271.3 26.4 6.2e-15 55.0 1.6 8.0 8 0 0 8 8 8 6 CAP-Gly domain WD40_4 PF16300.5 ETO31192.1 - 9.3e-19 67.1 0.0 1.8e-18 66.1 0.0 1.5 1 0 0 1 1 1 1 Type of WD40 repeat WD40 PF00400.32 ETO31192.1 - 4.7e-11 43.1 0.2 0.0023 18.7 0.0 3.7 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31192.1 - 2.8e-05 24.3 0.1 0.0014 18.9 0.1 2.9 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain PikAIV_N PF18605.1 ETO31192.1 - 0.056 13.0 5.1 0.16 11.5 5.1 1.8 1 0 0 1 1 1 0 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain Cupin_1 PF00190.22 ETO31192.1 - 0.092 12.4 0.0 0.17 11.5 0.0 1.4 1 0 0 1 1 1 0 Cupin PKcGMP_CC PF16808.5 ETO31192.1 - 0.12 12.2 2.3 0.16 11.8 0.1 2.1 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DivIC PF04977.15 ETO31192.1 - 0.13 12.1 0.5 0.44 10.4 0.5 1.9 1 0 0 1 1 1 0 Septum formation initiator DUF1899 PF08953.11 ETO31193.1 - 6.3e-19 67.6 0.1 1.2e-18 66.7 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) DOCK-C2 PF14429.6 ETO31194.1 - 0.089 12.6 0.0 0.11 12.3 0.0 1.2 1 0 0 1 1 1 0 C2 domain in Dock180 and Zizimin proteins Leu_zip PF15294.6 ETO31195.1 - 0.00021 20.9 8.6 0.00021 20.9 8.6 4.3 2 1 2 4 4 4 1 Leucine zipper DUF2205 PF10224.9 ETO31195.1 - 0.0024 17.8 1.3 0.0024 17.8 1.3 5.0 4 2 1 5 5 5 1 Short coiled-coil protein NAD_binding_6 PF08030.12 ETO31196.1 - 8.2e-07 29.3 0.0 2.7e-06 27.6 0.0 1.7 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ETO31196.1 - 0.0031 18.1 0.0 0.054 14.1 0.0 2.3 2 1 0 2 2 2 1 Oxidoreductase NAD-binding domain DYW_deaminase PF14432.6 ETO31197.1 - 0.074 12.9 0.9 0.17 11.7 0.2 1.9 2 0 0 2 2 2 0 DYW family of nucleic acid deaminases Methyltransf_PK PF05891.12 ETO31197.1 - 0.092 12.2 0.1 0.14 11.6 0.1 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase DUF1699 PF08004.11 ETO31197.1 - 0.24 11.1 3.4 0.26 11.0 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1699) Suf PF05843.14 ETO31198.1 - 0.87 9.5 6.4 1.5 8.8 6.4 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) EPL1 PF10513.9 ETO31198.1 - 0.93 9.9 15.8 0.23 11.8 10.1 2.2 2 0 0 2 2 2 0 Enhancer of polycomb-like GEMIN8 PF15348.6 ETO31198.1 - 1.8 8.8 12.8 2.1 8.6 0.1 2.3 2 0 0 2 2 2 0 Gemini of Cajal bodies-associated protein 8 Mpp10 PF04006.12 ETO31198.1 - 1.8 6.9 19.0 2.9 6.2 19.0 1.2 1 0 0 1 1 1 0 Mpp10 protein Mem_trans PF03547.18 ETO31199.1 - 0.012 14.1 3.0 0.013 13.9 3.0 1.0 1 0 0 1 1 1 0 Membrane transport protein DUF4318 PF14201.6 ETO31199.1 - 0.061 13.8 0.1 0.11 13.0 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4318) Mucin PF01456.17 ETO31200.1 - 1.3 9.0 23.8 0.032 14.2 16.0 2.3 3 0 0 3 3 3 0 Mucin-like glycoprotein Nop14 PF04147.12 ETO31200.1 - 6.1 4.9 52.7 0.013 13.8 35.6 2.3 2 0 0 2 2 2 0 Nop14-like family Band_7 PF01145.25 ETO31202.1 - 7.2e-18 65.2 3.4 7.2e-18 65.2 3.4 1.4 2 0 0 2 2 2 1 SPFH domain / Band 7 family Band_7_1 PF13421.6 ETO31202.1 - 0.0021 17.8 1.0 0.0035 17.1 0.4 1.7 2 0 0 2 2 2 1 SPFH domain-Band 7 family Capsule_synth PF05159.14 ETO31202.1 - 0.011 15.1 0.3 0.018 14.5 0.3 1.3 1 0 0 1 1 1 0 Capsule polysaccharide biosynthesis protein DUF4027 PF13219.6 ETO31203.1 - 0.23 11.3 3.2 0.68 9.9 3.2 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF4027) CBS PF00571.28 ETO31204.1 - 2.6e-07 31.0 0.0 2.6e-05 24.5 0.0 2.4 2 0 0 2 2 2 1 CBS domain Crust_neurohorm PF01147.17 ETO31204.1 - 0.08 12.8 0.0 0.17 11.7 0.0 1.5 1 0 0 1 1 1 0 Crustacean CHH/MIH/GIH neurohormone family Bcr-Abl_Oligo PF09036.10 ETO31204.1 - 0.16 12.0 0.5 0.72 9.9 0.2 2.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain DUF3484 PF11983.8 ETO31205.1 - 2.5 9.3 7.2 2.8 9.1 6.1 1.6 1 1 1 2 2 2 0 Membrane-attachment and polymerisation-promoting switch DnaJ PF00226.31 ETO31207.1 - 3.9e-19 68.5 2.5 8.9e-19 67.4 2.5 1.7 1 0 0 1 1 1 1 DnaJ domain RRM_1 PF00076.22 ETO31207.1 - 0.0014 18.4 0.0 0.0041 16.9 0.0 1.7 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHASE3 PF05227.13 ETO31207.1 - 0.074 13.0 5.2 0.13 12.1 5.2 1.5 1 0 0 1 1 1 0 CHASE3 domain RRM_occluded PF16842.5 ETO31207.1 - 0.09 12.6 0.0 0.24 11.3 0.0 1.7 1 0 0 1 1 1 0 Occluded RNA-recognition motif SepSecS PF05889.13 ETO31207.1 - 0.27 9.9 2.7 0.37 9.4 2.7 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Phage_GPO PF05929.11 ETO31207.1 - 0.29 10.7 5.2 0.047 13.3 0.6 1.8 1 1 1 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase Kelch_6 PF13964.6 ETO31209.1 - 6.7e-05 23.0 0.9 1.1 9.6 0.0 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO31209.1 - 0.00011 22.1 0.5 7.9 6.6 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO31209.1 - 0.0023 17.5 4.2 0.36 10.5 0.2 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO31209.1 - 0.005 16.8 2.1 6.3 6.9 0.1 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO31209.1 - 0.023 14.7 0.2 2.7 8.0 0.0 3.2 3 0 0 3 3 3 0 Galactose oxidase, central domain WD40 PF00400.32 ETO31210.1 - 5.5e-47 156.8 7.9 1.4e-11 44.7 0.1 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31210.1 - 2.7e-16 59.6 0.3 0.0043 17.3 0.0 4.7 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31210.1 - 2.6e-10 40.1 0.2 0.00028 20.3 0.0 2.2 2 0 0 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO31210.1 - 3.3e-08 33.6 0.0 0.00059 19.8 0.0 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Str_synth PF03088.16 ETO31210.1 - 2.5e-05 24.3 0.0 4.3 7.5 0.0 3.8 1 1 3 4 4 4 2 Strictosidine synthase Nup160 PF11715.8 ETO31210.1 - 2.6e-05 23.1 0.1 0.34 9.5 0.1 3.2 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO31210.1 - 3e-05 23.1 0.0 1.7 7.6 0.0 3.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Proteasome_A_N PF10584.9 ETO31210.1 - 7.2e-05 22.4 3.0 8.7 6.1 0.0 4.6 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature PD40 PF07676.12 ETO31210.1 - 0.00036 20.4 4.8 10 6.2 0.0 4.5 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO31210.1 - 0.00055 19.6 0.1 0.86 9.1 0.0 2.5 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO31210.1 - 0.0011 17.6 0.2 0.88 8.0 0.0 2.5 1 1 2 3 3 3 3 Cytochrome D1 heme domain FBD PF08387.10 ETO31210.1 - 0.01 15.7 0.0 0.7 9.8 0.0 2.5 2 0 0 2 2 2 0 FBD DUF5570 PF17731.1 ETO31210.1 - 0.01 15.9 1.7 24 5.0 0.0 3.6 2 1 2 4 4 4 0 Family of unknown function (DUF5570) AcetylCoA_hyd_C PF13336.6 ETO31210.1 - 0.01 15.8 0.5 22 4.9 0.0 3.8 3 1 1 4 4 4 0 Acetyl-CoA hydrolase/transferase C-terminal domain Ret2_MD PF18528.1 ETO31210.1 - 0.048 14.0 0.0 58 4.2 0.0 3.4 2 1 1 3 3 3 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Arylsulfotran_2 PF14269.6 ETO31210.1 - 0.048 13.0 0.4 0.086 12.2 0.3 1.3 1 1 0 1 1 1 0 Arylsulfotransferase (ASST) Me-amine-dh_H PF06433.11 ETO31210.1 - 0.054 12.4 0.0 0.64 8.8 0.0 2.4 2 1 2 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) Nucleoporin_N PF08801.11 ETO31210.1 - 0.061 12.1 2.1 9.6 4.8 0.9 3.1 1 1 1 2 2 2 0 Nup133 N terminal like Ta0938 PF11494.8 ETO31210.1 - 0.066 13.5 0.2 13 6.2 0.0 3.4 3 1 0 3 3 3 0 Ta0938 PQQ_2 PF13360.6 ETO31210.1 - 0.081 12.5 0.0 0.59 9.7 0.0 2.1 1 1 1 2 2 2 0 PQQ-like domain DDE_3 PF13358.6 ETO31211.1 - 0.067 12.9 0.2 0.079 12.7 0.2 1.3 1 0 0 1 1 1 0 DDE superfamily endonuclease IZUMO PF15005.6 ETO31215.1 - 0.061 13.8 0.4 0.26 11.8 0.4 2.2 1 0 0 1 1 1 0 Izumo sperm-egg fusion, Ig domain-associated SAM_1 PF00536.30 ETO31215.1 - 0.066 13.7 0.1 0.26 11.7 0.1 2.1 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF1977 PF09320.11 ETO31216.1 - 0.053 13.8 0.1 0.13 12.6 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1977) Img2 PF05046.14 ETO31216.1 - 0.12 12.7 0.0 0.46 10.8 0.0 2.0 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) AAA_8 PF12780.7 ETO31217.1 - 1.6e-07 31.0 0.0 5.7e-07 29.1 0.0 2.0 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 AAA PF00004.29 ETO31217.1 - 3.8e-07 30.6 0.1 9.7e-06 26.0 0.0 3.1 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) AAA_14 PF13173.6 ETO31217.1 - 3.7e-05 23.8 0.5 0.0017 18.4 0.0 3.8 4 0 0 4 4 4 1 AAA domain AAA_5 PF07728.14 ETO31217.1 - 4e-05 23.6 0.0 0.00018 21.5 0.0 2.1 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO31217.1 - 4.2e-05 24.1 0.2 0.00037 21.0 0.0 2.4 2 0 0 2 2 2 1 ABC transporter AAA_7 PF12775.7 ETO31217.1 - 0.0042 16.6 0.0 0.025 14.1 0.0 2.2 2 0 0 2 2 2 1 P-loop containing dynein motor region AAA_22 PF13401.6 ETO31217.1 - 0.0062 16.8 0.1 0.054 13.8 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO31217.1 - 0.057 13.8 0.0 0.3 11.5 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain AAA_3 PF07726.11 ETO31217.1 - 0.072 13.0 0.0 0.38 10.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) MCM PF00493.23 ETO31217.1 - 0.078 12.1 0.0 0.17 10.9 0.0 1.6 1 0 0 1 1 1 0 MCM P-loop domain RuvB_N PF05496.12 ETO31217.1 - 0.1 12.3 0.1 0.27 11.0 0.1 1.6 1 0 0 1 1 1 0 Holliday junction DNA helicase RuvB P-loop domain TsaE PF02367.17 ETO31217.1 - 0.11 12.5 0.0 0.44 10.6 0.0 2.0 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Zeta_toxin PF06414.12 ETO31217.1 - 0.13 11.5 0.0 3.2 7.0 0.0 2.4 2 0 0 2 2 2 0 Zeta toxin AAA_23 PF13476.6 ETO31217.1 - 1.5 9.2 11.7 2.1 8.8 0.1 3.1 2 1 0 2 2 2 0 AAA domain YojJ PF10372.9 ETO31218.1 - 0.11 12.6 0.5 0.72 10.0 0.0 2.2 2 0 0 2 2 2 0 Bacterial membrane-spanning protein N-terminus Ecm29 PF13001.7 ETO31220.1 - 3.5e-05 22.7 0.0 4.6e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 Proteasome stabiliser Syntaxin_2 PF14523.6 ETO31220.1 - 0.14 12.5 2.7 6.2 7.3 0.6 2.1 2 0 0 2 2 2 0 Syntaxin-like protein Cytochrom_C_asm PF01578.20 ETO31222.1 - 0.0088 15.8 11.2 0.027 14.2 11.2 1.6 1 1 0 1 1 1 1 Cytochrome C assembly protein DUF2663 PF10864.8 ETO31222.1 - 1.9 8.9 7.8 1.4 9.4 1.8 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2663) ART PF01129.18 ETO31224.1 - 0.0011 18.3 0.0 0.0024 17.2 0.0 1.6 1 0 0 1 1 1 1 NAD:arginine ADP-ribosyltransferase WD40 PF00400.32 ETO31226.1 - 1.8e-25 88.7 4.5 4.4e-09 36.8 0.2 6.1 5 1 1 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31226.1 - 1.9e-07 31.2 0.5 0.097 13.0 0.0 4.0 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31226.1 - 0.00032 20.1 1.1 0.052 12.9 0.1 2.5 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO31226.1 - 0.00073 19.5 0.0 0.0051 16.7 0.0 2.3 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nucleoporin_N PF08801.11 ETO31226.1 - 0.0023 16.8 0.1 0.95 8.1 0.0 2.1 1 1 1 2 2 2 2 Nup133 N terminal like Nup160 PF11715.8 ETO31226.1 - 0.019 13.6 0.2 0.18 10.4 0.1 2.1 1 1 1 2 2 2 0 Nucleoporin Nup120/160 PD40 PF07676.12 ETO31226.1 - 0.029 14.3 3.7 5.6 7.0 0.0 4.1 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Vint PF14623.6 ETO31226.1 - 0.062 13.1 0.1 6.5 6.5 0.0 2.8 1 1 2 3 3 3 0 Hint-domain DUF1513 PF07433.11 ETO31226.1 - 0.098 11.7 0.0 5.9 5.9 0.0 2.6 1 1 1 3 3 3 0 Protein of unknown function (DUF1513) PRK PF00485.18 ETO31227.1 - 4.7e-08 33.0 0.1 1.6e-07 31.3 0.1 1.9 1 1 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family ABC_tran PF00005.27 ETO31227.1 - 3.8e-05 24.2 0.0 9e-05 23.0 0.0 1.7 1 0 0 1 1 1 1 ABC transporter AAA_18 PF13238.6 ETO31227.1 - 0.0002 21.9 1.7 0.0007 20.2 0.2 2.6 1 1 1 2 2 2 1 AAA domain AAA_5 PF07728.14 ETO31227.1 - 0.00078 19.4 0.1 0.0048 16.9 0.0 2.2 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ETO31227.1 - 0.0019 18.1 0.0 0.0034 17.3 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_29 PF13555.6 ETO31227.1 - 0.0024 17.6 0.0 0.0046 16.7 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain NB-ARC PF00931.22 ETO31227.1 - 0.0038 16.5 0.5 0.013 14.7 0.0 2.2 3 1 0 3 3 3 1 NB-ARC domain KAP_NTPase PF07693.14 ETO31227.1 - 0.004 16.4 0.0 0.0072 15.6 0.0 1.4 1 0 0 1 1 1 1 KAP family P-loop domain AAA_16 PF13191.6 ETO31227.1 - 0.0042 17.5 0.0 0.0082 16.5 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO31227.1 - 0.0059 16.9 0.7 0.019 15.2 0.0 2.3 3 1 0 3 3 3 1 AAA domain RNA_helicase PF00910.22 ETO31227.1 - 0.0061 16.9 0.2 0.034 14.5 0.0 2.4 2 0 0 2 2 2 1 RNA helicase 6PF2K PF01591.18 ETO31227.1 - 0.007 15.7 0.7 0.012 14.9 0.1 1.7 2 0 0 2 2 2 1 6-phosphofructo-2-kinase MMR_HSR1 PF01926.23 ETO31227.1 - 0.0088 16.1 0.0 0.021 14.9 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase MeaB PF03308.16 ETO31227.1 - 0.035 13.1 0.0 0.058 12.4 0.0 1.3 1 0 0 1 1 1 0 Methylmalonyl Co-A mutase-associated GTPase MeaB NTPase_1 PF03266.15 ETO31227.1 - 0.065 13.1 0.0 0.15 12.0 0.0 1.7 1 0 0 1 1 1 0 NTPase GTP_EFTU PF00009.27 ETO31227.1 - 0.11 12.1 0.0 0.24 10.9 0.0 1.6 1 0 0 1 1 1 0 Elongation factor Tu GTP binding domain AAA_17 PF13207.6 ETO31227.1 - 0.14 12.5 0.0 8.4 6.8 0.0 2.5 2 0 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETO31227.1 - 0.23 11.9 9.0 0.021 15.3 3.3 2.1 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO31227.1 - 0.27 10.9 1.4 0.43 10.3 0.2 2.0 2 1 0 3 3 3 0 AAA domain AAA_14 PF13173.6 ETO31227.1 - 0.31 11.1 3.2 3.5 7.7 0.0 2.8 3 0 0 3 3 3 0 AAA domain Herpes_BBRF1 PF04793.12 ETO31228.1 - 0.033 13.2 0.8 0.17 10.9 0.2 2.0 2 0 0 2 2 2 0 BRRF1-like protein DUF2398 PF09661.10 ETO31228.1 - 0.26 10.5 0.0 0.41 9.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2398) Baculo_11_kDa PF06143.11 ETO31229.1 - 0.015 14.8 4.1 0.45 10.1 0.2 3.4 3 0 0 3 3 3 0 Baculovirus 11 kDa family T4_Gp59_N PF08993.10 ETO31229.1 - 0.14 12.6 2.8 0.32 11.4 1.7 2.2 2 0 0 2 2 2 0 T4 gene Gp59 loader of gp41 DNA helicase Mucin PF01456.17 ETO31229.1 - 0.15 12.1 26.8 0.54 10.3 26.8 1.9 1 0 0 1 1 1 0 Mucin-like glycoprotein Clathrin PF00637.20 ETO31230.1 - 1.2e-12 47.9 4.3 6.8e-07 29.3 0.5 3.1 3 0 0 3 3 3 2 Region in Clathrin and VPS UNC80 PF15778.5 ETO31230.1 - 0.096 12.3 0.4 0.27 10.8 0.0 1.9 2 0 0 2 2 2 0 Cation channel complex component UNC80 TINF2_N PF14973.6 ETO31231.1 - 0.71 10.2 3.7 0.61 10.4 1.5 1.9 1 1 1 2 2 2 0 TERF1-interacting nuclear factor 2 N-terminus DUF3395 PF11875.8 ETO31232.1 - 0.0058 16.5 7.7 0.39 10.6 0.1 4.5 4 2 1 5 5 5 2 Domain of unknown function (DUF3395) DUF977 PF06163.11 ETO31232.1 - 0.03 14.3 0.2 0.21 11.5 0.0 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF977) Defensin_big PF14862.6 ETO31232.1 - 0.05 13.9 0.2 26 5.2 0.0 3.9 4 0 0 4 4 4 0 Big defensin Gal_Lectin PF02140.18 ETO31232.1 - 0.58 10.6 2.4 4.3 7.8 0.1 3.4 4 0 0 4 4 4 0 Galactose binding lectin domain WD40 PF00400.32 ETO31233.1 - 1.9e-137 443.1 54.0 6.3e-09 36.3 0.1 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31233.1 - 3.4e-34 117.0 20.6 0.0024 18.2 0.1 12.9 1 1 13 14 14 14 13 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31233.1 - 3.3e-24 85.5 5.6 0.13 11.2 0.0 12.2 2 2 9 12 12 12 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO31233.1 - 3.1e-21 76.0 9.8 0.00029 20.2 0.0 8.0 4 3 3 9 9 9 6 WD40-like domain Nup160 PF11715.8 ETO31233.1 - 1.2e-14 53.8 32.0 0.47 9.0 0.0 13.3 5 3 9 14 14 14 8 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO31233.1 - 6.3e-08 32.1 0.7 1.4e-07 31.0 0.7 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) SGL PF08450.12 ETO31233.1 - 3.7e-06 26.7 3.7 0.32 10.5 0.1 5.3 1 1 1 4 4 4 2 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO31233.1 - 3.6e-05 22.5 9.8 0.25 9.9 0.1 5.8 3 2 3 7 7 7 3 Cytochrome D1 heme domain Str_synth PF03088.16 ETO31233.1 - 9.8e-05 22.4 1.7 28 4.9 0.0 7.8 8 3 3 11 11 10 0 Strictosidine synthase DUF3475 PF11961.8 ETO31233.1 - 0.00075 19.5 0.3 23 5.1 0.0 6.0 7 0 0 7 7 6 0 Domain of unknown function (DUF3475) Pentapeptide_4 PF13599.6 ETO31233.1 - 0.0011 19.1 0.4 0.0034 17.5 0.1 2.0 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) DUF5319 PF17252.2 ETO31233.1 - 0.017 15.3 0.1 38 4.6 0.0 5.4 4 2 0 6 6 6 0 Family of unknown function (DUF5319) Mid2 PF04478.12 ETO31233.1 - 0.026 14.4 6.5 12 5.8 0.1 6.6 5 3 4 9 9 9 0 Mid2 like cell wall stress sensor pRN1_helical PF13010.6 ETO31233.1 - 0.086 12.8 0.4 30 4.6 0.0 4.0 4 0 0 4 4 4 0 Primase helical domain Pentapeptide_3 PF13576.6 ETO31233.1 - 0.12 12.6 0.7 0.42 10.8 0.1 2.2 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO31233.1 - 0.28 11.2 21.1 48 4.1 0.1 8.1 9 0 0 9 9 9 0 WD40-like Beta Propeller Repeat TRAPP PF04051.16 ETO31235.1 - 0.037 13.7 0.5 0.053 13.2 0.4 1.3 1 1 0 1 1 1 0 Transport protein particle (TRAPP) component UvrB_inter PF17757.1 ETO31235.1 - 0.061 13.5 1.9 0.49 10.6 1.9 2.1 1 1 0 1 1 1 0 UvrB interaction domain Nuc_H_symport PF03825.16 ETO31236.1 - 6e-05 22.2 0.7 6e-05 22.2 0.7 1.6 1 1 0 1 1 1 1 Nucleoside H+ symporter MFS_1 PF07690.16 ETO31236.1 - 0.0021 17.0 22.4 0.052 12.5 23.1 2.2 1 1 0 1 1 1 1 Major Facilitator Superfamily TauE PF01925.19 ETO31236.1 - 0.049 13.2 13.9 0.13 11.9 14.1 1.6 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE Cation_ATPase_N PF00690.26 ETO31236.1 - 0.19 11.4 4.5 8.6 6.1 0.1 3.6 4 0 0 4 4 4 0 Cation transporter/ATPase, N-terminus DUF4231 PF14015.6 ETO31236.1 - 0.25 11.8 2.4 1.1 9.7 0.2 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4231) MFS_1_like PF12832.7 ETO31236.1 - 0.27 10.1 10.5 1.2 7.9 10.5 1.8 1 1 0 1 1 1 0 MFS_1 like family VIT1 PF01988.19 ETO31236.1 - 3.8 7.3 10.5 0.67 9.8 3.7 2.2 2 0 0 2 2 2 0 VIT family DUF4878 PF12870.7 ETO31237.1 - 0.015 15.6 4.0 0.015 15.6 4.0 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4878) CFIA_Pcf11 PF11526.8 ETO31237.1 - 0.18 12.3 11.0 0.14 12.6 1.0 2.5 2 0 0 2 2 2 0 Subunit of cleavage factor IA Pcf11 SRP9-21 PF05486.12 ETO31238.1 - 0.0037 17.6 1.1 0.0037 17.6 1.1 2.3 1 1 1 2 2 2 1 Signal recognition particle 9 kDa protein (SRP9) ResIII PF04851.15 ETO31238.1 - 0.52 10.3 6.3 0.29 11.1 3.3 2.1 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit GrpE PF01025.19 ETO31239.1 - 4.6e-38 130.5 11.5 2.4e-37 128.2 11.5 1.9 1 1 0 1 1 1 1 GrpE PRF PF06875.11 ETO31239.1 - 0.035 13.5 0.0 0.057 12.8 0.0 1.3 1 0 0 1 1 1 0 Plethodontid receptivity factor PRF B56 PF01603.20 ETO31240.1 - 3.3e-92 309.6 9.4 4.4e-92 309.2 9.4 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) Ycf70 PF17382.2 ETO31241.1 - 0.015 15.7 1.9 0.015 15.7 1.9 1.8 1 1 1 2 2 2 0 Uncharacterized Ycf70-like NfI_DNAbd_pre-N PF10524.9 ETO31241.1 - 0.029 14.2 0.1 0.064 13.1 0.1 1.6 1 0 0 1 1 1 0 Nuclear factor I protein pre-N-terminus Connexin PF00029.19 ETO31241.1 - 0.063 13.0 1.9 0.083 12.6 1.9 1.2 1 0 0 1 1 1 0 Connexin CSG2 PF16965.5 ETO31241.1 - 0.088 11.7 0.8 0.11 11.4 0.8 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator MRJP PF03022.16 ETO31242.1 - 7e-19 68.3 0.1 9.1e-19 67.9 0.1 1.1 1 0 0 1 1 1 1 Major royal jelly protein OGG_N PF07934.12 ETO31243.1 - 0.0028 17.8 0.7 0.0032 17.5 0.7 1.2 1 0 0 1 1 1 1 8-oxoguanine DNA glycosylase, N-terminal domain MscS_porin PF12795.7 ETO31243.1 - 0.0032 17.0 4.3 0.0041 16.7 4.3 1.2 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain CALCOCO1 PF07888.11 ETO31243.1 - 0.016 14.1 6.7 0.018 13.9 6.7 1.1 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like Baculo_PEP_C PF04513.12 ETO31243.1 - 0.023 14.8 0.6 0.029 14.4 0.6 1.1 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apt1 PF10351.9 ETO31243.1 - 0.037 12.9 4.4 0.04 12.8 4.4 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ribosomal_L17 PF01196.19 ETO31243.1 - 0.078 13.9 0.3 0.099 13.5 0.3 1.1 1 0 0 1 1 1 0 Ribosomal protein L17 AA_synth PF06684.11 ETO31243.1 - 0.11 12.1 0.2 0.13 11.8 0.2 1.2 1 0 0 1 1 1 0 Amino acid synthesis TolA_bind_tri PF16331.5 ETO31243.1 - 0.12 12.5 2.9 0.22 11.6 2.9 1.6 1 1 0 1 1 1 0 TolA binding protein trimerisation DUF724 PF05266.14 ETO31243.1 - 0.16 11.8 7.1 0.2 11.5 7.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF724) Spc7 PF08317.11 ETO31243.1 - 0.18 10.7 9.7 0.2 10.5 9.7 1.1 1 0 0 1 1 1 0 Spc7 kinetochore protein COMM_domain PF07258.14 ETO31243.1 - 0.25 11.5 3.8 0.29 11.3 1.7 2.0 1 1 1 2 2 2 0 COMM domain Fmp27_WPPW PF10359.9 ETO31243.1 - 0.34 9.7 7.6 0.36 9.6 7.6 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF4407 PF14362.6 ETO31243.1 - 0.7 9.2 4.5 0.77 9.0 4.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DAP PF15228.6 ETO31246.1 - 0.087 14.0 2.2 0.11 13.6 2.2 1.2 1 0 0 1 1 1 0 Death-associated protein Mito_carr PF00153.27 ETO31247.1 - 2.8e-26 91.3 0.3 2.8e-12 46.4 0.0 2.1 1 1 1 2 2 2 2 Mitochondrial carrier protein Tim17 PF02466.19 ETO31247.1 - 0.048 14.0 0.2 0.066 13.6 0.2 1.3 1 0 0 1 1 1 0 Tim17/Tim22/Tim23/Pmp24 family Mito_carr PF00153.27 ETO31248.1 - 0.044 13.7 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 Mitochondrial carrier protein XK-related PF09815.9 ETO31250.1 - 6.9e-05 22.1 0.3 0.014 14.4 0.0 2.1 2 0 0 2 2 2 2 XK-related protein DUF3169 PF11368.8 ETO31250.1 - 0.053 13.0 2.5 0.083 12.4 0.2 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3169) DUF1492 PF07374.11 ETO31251.1 - 0.081 13.1 0.1 9.3 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1492) GTP1_OBG PF01018.22 ETO31252.1 - 0.074 12.6 3.7 0.094 12.3 3.7 1.2 1 0 0 1 1 1 0 GTP1/OBG HTH_ABP1_N PF18107.1 ETO31253.1 - 0.38 10.5 4.1 1.2 8.9 0.6 2.4 2 0 0 2 2 2 0 Fission yeast centromere protein N-terminal domain WD40 PF00400.32 ETO31254.1 - 1.2e-35 120.8 24.2 8.4e-06 26.4 0.2 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31254.1 - 5.4e-10 39.4 3.3 0.33 11.3 0.1 5.3 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31254.1 - 1.9e-06 26.8 3.9 4 6.0 0.0 5.0 3 2 2 5 5 5 5 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO31254.1 - 0.0031 17.5 1.8 0.62 10.1 0.1 3.8 3 2 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region PQQ_3 PF13570.6 ETO31254.1 - 0.059 13.9 0.9 23 5.6 0.0 4.2 4 0 0 4 4 4 0 PQQ-like domain Glyco_hydro38C2 PF17677.1 ETO31255.1 - 0.046 13.8 0.2 0.14 12.3 0.1 1.9 2 0 0 2 2 2 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain WD40 PF00400.32 ETO31256.1 - 2.5e-78 256.0 45.9 2.8e-08 34.3 0.1 13.8 15 0 0 15 15 15 11 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31256.1 - 1.9e-17 63.3 21.7 0.054 13.8 0.1 11.0 2 2 9 11 11 11 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31256.1 - 8.3e-14 51.6 21.0 9.7e-05 21.8 0.6 5.5 4 1 1 5 5 5 4 WD40-like domain Plk4_PB2 PF18409.1 ETO31256.1 - 0.02 15.6 0.6 15 6.3 0.0 4.6 3 2 1 4 4 4 0 Polo-like Kinase 4 Polo Box 2 Plant_vir_prot PF01307.17 ETO31256.1 - 0.16 12.2 0.5 3.7 7.8 0.0 2.7 1 1 1 2 2 2 0 Plant viral movement protein Plk4_PB1 PF18190.1 ETO31256.1 - 0.19 11.9 3.2 0.89 9.7 0.1 3.7 4 1 0 4 4 4 0 Polo-like Kinase 4 Polo Box 1 PD40 PF07676.12 ETO31256.1 - 0.23 11.5 8.2 92 3.2 0.1 6.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Myc_N PF01056.18 ETO31258.1 - 0.026 14.5 0.3 0.042 13.8 0.3 1.3 1 0 0 1 1 1 0 Myc amino-terminal region PNISR PF15996.5 ETO31258.1 - 0.035 14.4 0.1 0.048 13.9 0.1 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PapD_N PF00345.20 ETO31258.1 - 0.055 13.4 0.1 0.088 12.7 0.1 1.3 1 0 0 1 1 1 0 Pili and flagellar-assembly chaperone, PapD N-terminal domain TFIIE-A_C PF11521.8 ETO31258.1 - 1 9.7 5.6 1.6 9.1 5.6 1.3 1 0 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha DUF3906 PF13046.6 ETO31259.1 - 0.07 13.2 0.4 0.17 12.0 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3906) Pup PF05639.11 ETO31259.1 - 0.46 11.4 4.8 0.23 12.4 0.7 2.5 2 1 1 3 3 3 0 Pup-like protein DUF220 PF02713.14 ETO31260.1 - 0.11 12.6 0.0 0.29 11.3 0.0 1.7 1 0 0 1 1 1 0 Domain of unknown function DUF220 PBP1_TM PF14812.6 ETO31262.1 - 0.036 14.4 1.5 0.036 14.4 1.5 5.8 4 1 1 5 5 5 0 Transmembrane domain of transglycosylase PBP1 at N-terminal WD40 PF00400.32 ETO31263.1 - 2.7e-27 94.5 24.1 9.1e-06 26.3 0.1 6.9 5 1 1 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31263.1 - 3.3e-07 30.5 2.5 3.5 8.0 0.0 5.4 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31263.1 - 3.8e-06 25.9 10.7 0.4 9.3 0.0 4.4 3 2 2 5 5 5 4 Nucleoporin Nup120/160 Peptidase_S10 PF00450.22 ETO31264.1 - 5.7e-22 78.7 3.0 1.3e-21 77.5 3.0 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase DUF2052 PF09747.9 ETO31264.1 - 0.00027 21.2 1.3 0.00036 20.7 1.3 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) PAC1 PF16094.5 ETO31264.1 - 0.0052 16.0 0.6 0.0081 15.4 0.6 1.3 1 0 0 1 1 1 1 Proteasome assembly chaperone 4 KBP_C PF12309.8 ETO31264.1 - 0.0093 15.5 0.2 0.0093 15.5 0.2 1.1 1 0 0 1 1 1 1 KIF-1 binding protein C terminal RNA_pol_3_Rpc31 PF11705.8 ETO31264.1 - 0.0098 16.2 10.0 0.016 15.5 10.0 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 Radial_spoke PF04712.12 ETO31264.1 - 0.013 14.5 2.2 0.016 14.2 2.2 1.1 1 0 0 1 1 1 0 Radial spokehead-like protein BUD22 PF09073.10 ETO31264.1 - 0.016 14.6 1.0 0.016 14.6 1.0 1.2 1 0 0 1 1 1 0 BUD22 PDR_assoc PF08370.11 ETO31264.1 - 0.022 14.5 0.0 0.045 13.5 0.0 1.5 1 0 0 1 1 1 0 Plant PDR ABC transporter associated RXT2_N PF08595.11 ETO31264.1 - 0.039 14.0 2.4 0.059 13.4 2.4 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 ETO31264.1 - 0.06 11.4 8.7 0.084 11.0 8.7 1.2 1 0 0 1 1 1 0 DNA polymerase phi Cas_Csa4 PF09703.10 ETO31264.1 - 0.1 11.9 0.1 3.2 7.0 0.0 2.1 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Csa4) FAM176 PF14851.6 ETO31264.1 - 0.12 12.0 4.0 0.2 11.3 4.0 1.3 1 0 0 1 1 1 0 FAM176 family Cwf_Cwc_15 PF04889.12 ETO31264.1 - 0.12 12.0 5.9 0.18 11.5 5.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Pox_Ag35 PF03286.14 ETO31264.1 - 0.14 11.9 2.4 0.18 11.6 2.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CENP-B_dimeris PF09026.10 ETO31264.1 - 0.16 12.4 18.9 0.62 10.5 18.7 1.9 1 1 1 2 2 2 0 Centromere protein B dimerisation domain Nop14 PF04147.12 ETO31264.1 - 0.16 10.1 5.6 0.18 9.9 5.6 1.1 1 0 0 1 1 1 0 Nop14-like family NOA36 PF06524.12 ETO31264.1 - 0.17 11.2 7.5 0.23 10.7 7.5 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO31264.1 - 0.2 12.0 5.4 0.37 11.2 5.4 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Sporozoite_P67 PF05642.11 ETO31264.1 - 0.4 8.7 2.2 0.52 8.3 2.2 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen WRNPLPNID PF15017.6 ETO31264.1 - 0.51 11.3 11.8 0.33 11.8 9.7 1.7 2 0 0 2 2 1 0 Putative WW-binding domain and destruction box CDC45 PF02724.14 ETO31264.1 - 0.57 8.4 4.2 0.7 8.1 4.2 1.1 1 0 0 1 1 1 0 CDC45-like protein Astro_capsid_p PF12226.8 ETO31264.1 - 0.61 9.2 6.3 0.87 8.7 6.3 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF2457 PF10446.9 ETO31264.1 - 1.4 8.0 11.8 1.9 7.5 11.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Dicty_REP PF05086.12 ETO31264.1 - 3 5.7 5.9 3.6 5.5 5.9 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4637 PF15470.6 ETO31264.1 - 4.1 7.1 8.2 6.3 6.5 8.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF3073 PF11273.8 ETO31264.1 - 8.3 7.2 8.4 20 6.0 8.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3073) WD40 PF00400.32 ETO31265.1 - 1.1e-56 187.4 20.2 1.3e-09 38.5 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31265.1 - 2.5e-22 79.0 0.3 0.0014 18.9 0.0 5.5 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31265.1 - 1.3e-20 73.6 2.9 3.1e-05 23.1 0.1 5.8 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO31265.1 - 2.8e-09 36.0 0.6 0.033 12.7 0.0 4.0 1 1 3 4 4 4 3 Cytochrome D1 heme domain WD40_like PF17005.5 ETO31265.1 - 3.5e-08 33.1 0.4 0.064 12.6 0.0 3.7 1 1 3 4 4 4 3 WD40-like domain PD40 PF07676.12 ETO31265.1 - 6.2e-07 29.2 5.9 0.16 12.0 0.1 5.8 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO31265.1 - 6.4e-07 28.4 7.7 0.74 8.4 0.0 5.4 2 1 3 5 5 5 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO31265.1 - 7.1e-05 22.3 3.1 4 6.7 0.0 4.7 1 1 4 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO31265.1 - 7.7e-05 21.6 3.5 2.2 6.9 0.0 4.1 1 1 0 4 4 4 3 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO31265.1 - 0.004 16.8 10.5 4 7.2 0.0 6.3 7 0 0 7 7 7 1 Proteasome subunit A N-terminal signature Utp8 PF10395.9 ETO31265.1 - 0.0046 15.5 0.0 1.9 6.9 0.0 2.9 1 1 2 3 3 3 2 Utp8 family Str_synth PF03088.16 ETO31265.1 - 0.0087 16.2 3.5 11 6.3 0.0 4.5 4 2 2 6 6 6 2 Strictosidine synthase DUF5570 PF17731.1 ETO31265.1 - 0.086 12.9 0.4 24 5.0 0.0 3.3 1 1 2 3 3 3 0 Family of unknown function (DUF5570) VIT1 PF01988.19 ETO31266.1 - 1.4e-26 93.7 0.0 1.8e-26 93.3 0.0 1.1 1 0 0 1 1 1 1 VIT family Spore_III_AE PF09546.10 ETO31266.1 - 0.032 13.4 0.1 0.042 13.0 0.1 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AE (spore_III_AE) DUF3357 PF11837.8 ETO31268.1 - 0.13 12.8 0.0 0.21 12.1 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3357) Swi5 PF07061.11 ETO31269.1 - 7.9e-14 51.5 6.2 4.1e-13 49.2 6.2 2.1 1 1 0 1 1 1 1 Swi5 YfhO PF09586.10 ETO31269.1 - 0.54 8.4 5.5 0.62 8.2 5.5 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO PNISR PF15996.5 ETO31270.1 - 0.31 11.3 22.8 0.054 13.8 19.2 1.6 2 0 0 2 2 2 0 Arginine/serine-rich protein PNISR Zip PF02535.22 ETO31270.1 - 0.69 9.1 4.7 1 8.5 4.7 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter DUF5523 PF17661.1 ETO31270.1 - 0.71 9.5 23.7 1.2 8.7 23.7 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5523) BUD22 PF09073.10 ETO31270.1 - 1.3 8.3 26.4 2.2 7.5 26.4 1.3 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO31270.1 - 4.7 5.9 14.5 7.1 5.3 14.5 1.3 1 0 0 1 1 1 0 Presenilin HECT PF00632.25 ETO31271.1 - 4.3e-11 42.9 0.3 6.4e-11 42.3 0.3 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) Cornifin PF02389.15 ETO31271.1 - 0.13 12.5 0.4 0.19 11.9 0.4 1.2 1 0 0 1 1 1 0 Cornifin (SPRR) family YbjQ_1 PF01906.17 ETO31271.1 - 1.1 9.9 0.0 1.1 9.9 0.0 2.8 2 1 1 3 3 3 0 Putative heavy-metal-binding Asp-B-Hydro_N PF05279.11 ETO31271.1 - 2.6 8.0 30.6 3.8 7.5 30.6 1.3 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region SOBP PF15279.6 ETO31271.1 - 4.2 7.9 4.4 5.8 7.4 4.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein Presenilin PF01080.17 ETO31271.1 - 5.4 5.7 16.7 7.9 5.1 16.7 1.3 1 0 0 1 1 1 0 Presenilin Tim54 PF11711.8 ETO31272.1 - 0.013 14.4 0.4 0.014 14.2 0.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 NPR3 PF03666.13 ETO31272.1 - 0.033 13.0 4.3 0.037 12.8 4.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Strabismus PF06638.11 ETO31272.1 - 0.098 11.3 4.9 0.13 10.9 4.9 1.2 1 0 0 1 1 1 0 Strabismus protein Zip PF02535.22 ETO31272.1 - 0.1 11.8 0.1 0.1 11.8 0.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter SR-25 PF10500.9 ETO31272.1 - 0.77 9.3 21.6 1.3 8.6 21.6 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein TFIIF_alpha PF05793.12 ETO31272.1 - 3.2 6.2 23.4 4 5.9 23.4 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF4637 PF15470.6 ETO31272.1 - 4.6 7.0 7.6 7.3 6.3 7.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Sporozoite_P67 PF05642.11 ETO31272.1 - 5.1 5.0 13.8 6.6 4.7 13.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pox_Ag35 PF03286.14 ETO31272.1 - 5.5 6.7 15.4 8 6.2 15.4 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein PI3K_1B_p101 PF10486.9 ETO31272.1 - 8.8 4.0 11.0 12 3.6 11.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit PDR_CDR PF06422.12 ETO31273.1 - 0.22 11.4 3.9 0.35 10.8 3.9 1.5 1 1 0 1 1 1 0 CDR ABC transporter DBB PF14545.6 ETO31274.1 - 0.052 13.5 0.0 0.076 12.9 0.0 1.2 1 0 0 1 1 1 0 Dof, BCAP, and BANK (DBB) motif, MAPEG PF01124.18 ETO31274.1 - 0.12 12.3 0.6 14 5.6 0.1 2.6 2 1 0 2 2 2 0 MAPEG family Pkinase PF00069.25 ETO31275.1 - 2e-18 66.7 0.3 7e-11 42.0 0.0 3.1 1 1 2 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31275.1 - 5.2e-08 32.5 0.2 2.7e-05 23.6 0.0 2.7 2 1 1 3 3 3 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO31275.1 - 0.0032 16.3 0.0 0.005 15.7 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO31275.1 - 0.011 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MukE PF04288.13 ETO31275.1 - 0.014 14.4 0.1 0.032 13.1 0.1 1.7 1 1 0 1 1 1 0 MukE-like family Pkinase PF00069.25 ETO31276.1 - 8.3e-05 22.1 0.7 0.00013 21.4 0.1 1.6 2 0 0 2 2 2 1 Protein kinase domain CtIP_N PF10482.9 ETO31277.1 - 0.0097 16.0 12.6 0.0097 16.0 12.6 2.5 1 1 2 3 3 3 1 Tumour-suppressor protein CtIP N-terminal domain Leu_zip PF15294.6 ETO31277.1 - 0.017 14.6 24.4 0.031 13.8 24.5 1.3 1 1 0 1 1 1 0 Leucine zipper FUSC PF04632.12 ETO31277.1 - 0.023 13.3 2.9 0.026 13.1 2.9 1.0 1 0 0 1 1 1 0 Fusaric acid resistance protein family ApoO PF09769.9 ETO31277.1 - 0.068 13.1 4.0 0.17 11.9 4.0 1.7 1 1 0 1 1 1 0 Apolipoprotein O Prominin PF05478.11 ETO31277.1 - 0.085 10.8 11.5 0.088 10.8 11.5 1.1 1 0 0 1 1 1 0 Prominin AAA_11 PF13086.6 ETO31277.1 - 0.34 10.6 15.5 0.54 10.0 15.5 1.3 1 0 0 1 1 1 0 AAA domain TMPIT PF07851.13 ETO31277.1 - 0.46 9.7 19.6 0.017 14.4 13.3 1.6 2 0 0 2 2 2 0 TMPIT-like protein Histidinol_dh PF00815.20 ETO31277.1 - 0.6 9.1 5.9 0.84 8.6 5.9 1.2 1 0 0 1 1 1 0 Histidinol dehydrogenase OmpH PF03938.14 ETO31277.1 - 0.6 10.4 26.4 0.05 14.0 18.8 2.0 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) MutS_III PF05192.18 ETO31277.1 - 0.78 9.9 7.7 0.95 9.7 7.7 1.2 1 0 0 1 1 1 0 MutS domain III DUF812 PF05667.11 ETO31277.1 - 1.1 8.0 24.5 1.4 7.7 24.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF4407 PF14362.6 ETO31277.1 - 1.4 8.2 14.3 2.1 7.6 14.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ATG16 PF08614.11 ETO31277.1 - 1.5 9.0 30.5 9.4 6.4 30.5 1.9 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) Fez1 PF06818.15 ETO31277.1 - 2.3 8.6 28.4 3.9 7.9 28.4 1.3 1 1 0 1 1 1 0 Fez1 Exonuc_VII_L PF02601.15 ETO31277.1 - 3.8 7.0 16.0 4.9 6.6 16.0 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit FAM76 PF16046.5 ETO31277.1 - 3.8 6.8 21.9 5.5 6.2 21.9 1.2 1 0 0 1 1 1 0 FAM76 protein RPN7 PF10602.9 ETO31277.1 - 3.9 7.2 14.0 0.78 9.4 5.9 2.6 1 1 1 2 2 2 0 26S proteasome subunit RPN7 Atg14 PF10186.9 ETO31277.1 - 4.2 6.4 24.3 8.3 5.4 24.3 1.4 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Jnk-SapK_ap_N PF09744.9 ETO31277.1 - 4.5 7.5 30.3 0.38 11.0 23.4 2.0 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 SpecificRecomb PF10136.9 ETO31277.1 - 4.8 5.4 6.6 5.3 5.2 6.6 1.1 1 0 0 1 1 1 0 Site-specific recombinase Hid1 PF12722.7 ETO31277.1 - 5.2 5.1 14.4 6.4 4.8 14.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein DUF1539 PF07560.11 ETO31277.1 - 6.6 6.8 12.0 4.1 7.5 10.1 1.6 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1539) ACCA PF03255.14 ETO31277.1 - 7.7 6.4 18.3 1.4 8.8 13.5 2.2 1 1 1 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit ZapB PF06005.12 ETO31277.1 - 7.7 7.0 37.4 1.2 9.6 6.8 3.1 2 1 1 3 3 3 0 Cell division protein ZapB DUF4200 PF13863.6 ETO31277.1 - 8.4 6.8 33.2 0.18 12.2 18.8 2.8 2 1 1 3 3 3 0 Domain of unknown function (DUF4200) Trimer_CC PF08954.11 ETO31277.1 - 9.4 5.9 17.6 1.6 8.3 6.1 2.6 2 0 0 2 2 2 0 Trimerisation motif DUF4710 PF15828.5 ETO31278.1 - 1.1 9.4 11.4 0.78 9.9 9.1 1.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4710) DUF3889 PF13028.6 ETO31279.1 - 0.031 14.2 0.1 0.067 13.1 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3889) Rep_fac_C PF08542.11 ETO31280.1 - 8.5e-16 58.1 0.0 6.3e-15 55.4 0.0 2.4 2 1 0 2 2 2 1 Replication factor C C-terminal domain AAA PF00004.29 ETO31280.1 - 2.1e-11 44.3 0.0 3.8e-11 43.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Rad17 PF03215.15 ETO31280.1 - 6.1e-07 29.5 0.0 9.8e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 Rad17 P-loop domain DNA_pol3_delta2 PF13177.6 ETO31280.1 - 5.5e-06 26.2 1.2 0.00067 19.5 1.2 3.0 1 1 0 1 1 1 1 DNA polymerase III, delta subunit AAA_16 PF13191.6 ETO31280.1 - 2.7e-05 24.6 0.0 7.3e-05 23.2 0.0 1.8 1 1 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 ETO31280.1 - 4.7e-05 22.9 0.0 9.4e-05 21.9 0.0 1.5 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_14 PF13173.6 ETO31280.1 - 4.8e-05 23.4 0.0 9.1e-05 22.5 0.0 1.5 1 0 0 1 1 1 1 AAA domain RuvB_N PF05496.12 ETO31280.1 - 0.0001 22.1 0.0 0.00024 20.9 0.0 1.7 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_22 PF13401.6 ETO31280.1 - 0.0005 20.3 0.8 0.055 13.7 0.1 2.8 1 1 1 3 3 3 1 AAA domain AAA_11 PF13086.6 ETO31280.1 - 0.0012 18.7 0.1 0.002 17.9 0.1 1.3 1 1 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETO31280.1 - 0.002 18.5 0.3 0.0084 16.5 0.3 2.0 1 1 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ETO31280.1 - 0.0046 16.7 0.0 0.0075 16.0 0.0 1.3 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase MeaB PF03308.16 ETO31280.1 - 0.0075 15.3 0.0 0.016 14.2 0.0 1.6 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB FtsK_SpoIIIE PF01580.18 ETO31280.1 - 0.012 15.0 0.0 0.019 14.3 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family TniB PF05621.11 ETO31280.1 - 0.02 14.3 0.1 0.094 12.1 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein AAA_24 PF13479.6 ETO31280.1 - 0.024 14.4 0.0 0.047 13.4 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO31280.1 - 0.025 14.3 0.0 0.11 12.2 0.0 1.9 1 1 1 2 2 2 0 AAA domain AAA_7 PF12775.7 ETO31280.1 - 0.031 13.8 0.0 0.075 12.5 0.0 1.7 1 1 0 1 1 1 0 P-loop containing dynein motor region SVM_signal PF12113.8 ETO31280.1 - 0.031 14.2 0.9 0.031 14.2 0.9 2.1 2 0 0 2 2 2 0 SVM protein signal sequence AAA_18 PF13238.6 ETO31280.1 - 0.035 14.7 0.0 0.095 13.3 0.0 1.8 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO31280.1 - 0.039 13.7 0.1 0.16 11.7 0.0 2.0 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO31280.1 - 0.042 14.4 0.1 0.1 13.1 0.1 1.7 1 1 0 1 1 1 0 ABC transporter T2SSE PF00437.20 ETO31280.1 - 0.054 12.5 0.1 0.12 11.4 0.1 1.5 1 1 0 1 1 1 0 Type II/IV secretion system protein AAA_3 PF07726.11 ETO31280.1 - 0.058 13.3 0.0 0.11 12.3 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_28 PF13521.6 ETO31280.1 - 0.093 13.0 0.0 0.16 12.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO31280.1 - 0.099 12.6 0.0 0.24 11.4 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) DUF202 PF02656.15 ETO31280.1 - 0.1 13.0 0.1 0.2 12.1 0.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF202) AAA_assoc_2 PF16193.5 ETO31280.1 - 0.11 12.9 0.0 1.6 9.1 0.0 2.4 1 1 1 2 2 2 0 AAA C-terminal domain NTPase_1 PF03266.15 ETO31280.1 - 0.11 12.4 2.4 0.12 12.2 0.1 2.4 3 1 0 3 3 1 0 NTPase RNA_helicase PF00910.22 ETO31280.1 - 0.12 12.8 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 RNA helicase AAA_23 PF13476.6 ETO31280.1 - 0.12 12.8 0.2 0.22 12.0 0.2 1.4 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 ETO31280.1 - 0.14 12.1 0.0 3.2 7.7 0.0 2.3 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit DUF2075 PF09848.9 ETO31280.1 - 0.2 10.9 0.2 1.7 7.8 0.2 2.0 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) LAP1C PF05609.12 ETO31281.1 - 0.024 13.7 21.3 0.03 13.4 21.3 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Vac7 PF12751.7 ETO31281.1 - 0.033 13.7 4.3 0.041 13.3 4.3 1.1 1 0 0 1 1 1 0 Vacuolar segregation subunit 7 DUF908 PF06012.12 ETO31281.1 - 0.1 12.0 6.3 0.13 11.6 6.3 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Neur_chan_memb PF02932.16 ETO31281.1 - 0.12 12.4 13.1 0.16 12.0 13.1 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Lin-8 PF03353.15 ETO31281.1 - 0.27 10.8 30.4 0.35 10.4 30.4 1.1 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist SLC12 PF03522.15 ETO31281.1 - 0.46 9.5 20.9 0.66 8.9 20.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 BT1 PF03092.16 ETO31281.1 - 0.51 8.5 7.8 0.78 7.9 7.7 1.4 1 1 0 1 1 1 0 BT1 family SDA1 PF05285.12 ETO31281.1 - 0.69 9.3 41.0 0.88 8.9 41.0 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO31281.1 - 1.4 7.2 37.4 1.8 6.8 37.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Raftlin PF15250.6 ETO31281.1 - 1.7 7.3 18.9 2.7 6.7 18.9 1.4 1 0 0 1 1 1 0 Raftlin LMBR1 PF04791.16 ETO31281.1 - 4.1 6.2 10.5 6.1 5.6 10.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Proteasome PF00227.26 ETO31282.1 - 1.2e-43 148.9 0.8 3e-23 82.3 0.0 3.1 3 0 0 3 3 3 3 Proteasome subunit GPI2 PF06432.11 ETO31282.1 - 0.19 11.1 5.0 0.048 13.1 1.8 1.6 2 0 0 2 2 2 0 Phosphatidylinositol N-acetylglucosaminyltransferase Wzy_C PF04932.15 ETO31283.1 - 0.051 13.2 0.4 0.069 12.8 0.4 1.3 1 0 0 1 1 1 0 O-Antigen ligase Tmemb_185A PF10269.9 ETO31283.1 - 0.056 13.1 2.3 0.083 12.6 1.8 1.4 1 1 0 1 1 1 0 Transmembrane Fragile-X-F protein PRK PF00485.18 ETO31283.1 - 0.064 13.0 0.1 0.13 12.0 0.1 1.4 1 0 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Vma12 PF11712.8 ETO31284.1 - 0.17 11.9 5.0 0.53 10.3 4.3 2.2 1 1 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase Peptidase_S49_N PF08496.10 ETO31284.1 - 0.36 10.9 11.3 9.9 6.2 9.7 2.4 2 0 0 2 2 2 0 Peptidase family S49 N-terminal STAS PF01740.21 ETO31286.1 - 1.8e-20 72.7 0.1 3e-20 72.0 0.1 1.3 1 0 0 1 1 1 1 STAS domain Sulfate_transp PF00916.20 ETO31286.1 - 4.4e-12 45.5 0.9 7e-12 44.8 0.9 1.3 1 0 0 1 1 1 1 Sulfate permease family B-block_TFIIIC PF04182.12 ETO31287.1 - 5.5e-09 36.1 0.3 1.1e-06 28.7 0.0 3.4 3 0 0 3 3 3 1 B-block binding subunit of TFIIIC z-alpha PF02295.17 ETO31287.1 - 0.0023 17.9 0.0 6.6 6.9 0.0 3.4 3 0 0 3 3 3 2 Adenosine deaminase z-alpha domain IF2_N PF04760.15 ETO31287.1 - 0.0099 15.7 1.0 0.046 13.5 0.0 2.6 4 0 0 4 4 4 1 Translation initiation factor IF-2, N-terminal region DUF3791 PF12668.7 ETO31287.1 - 0.036 14.1 0.4 0.2 11.7 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3791) Phage_int_SAM_4 PF13495.6 ETO31287.1 - 0.037 14.5 1.3 10 6.7 0.0 4.1 4 0 0 4 4 4 0 Phage integrase, N-terminal SAM-like domain DUF1573 PF07610.11 ETO31287.1 - 0.057 13.5 0.2 0.2 11.7 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1573) MarR_2 PF12802.7 ETO31287.1 - 0.12 12.3 0.0 0.44 10.5 0.0 2.0 2 0 0 2 2 2 0 MarR family CDK2AP PF09806.9 ETO31287.1 - 2.2 8.3 8.5 0.2 11.7 2.7 2.1 1 1 1 2 2 2 0 Cyclin-dependent kinase 2-associated protein Spc42p PF11544.8 ETO31288.1 - 0.012 15.6 2.9 0.012 15.6 2.9 6.2 5 1 0 5 5 5 0 Spindle pole body component Spc42p Peptidase_C12 PF01088.21 ETO31289.1 - 3.9e-39 134.6 0.2 4.5e-39 134.4 0.2 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 WD40 PF00400.32 ETO31290.1 - 1.4e-41 139.6 28.2 3.1e-07 31.0 0.1 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31290.1 - 1.6e-11 44.4 5.6 0.081 13.2 0.0 6.0 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31290.1 - 2.3e-09 36.5 3.1 0.1 11.3 0.0 5.1 4 1 1 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31290.1 - 1.4e-05 24.6 10.3 0.0057 16.0 1.9 4.5 2 2 2 4 4 4 3 WD40-like domain DUF4221 PF13970.6 ETO31290.1 - 0.0082 15.7 6.1 0.059 12.9 4.5 2.6 1 1 1 2 2 2 1 Domain of unknown function (DUF4221) Pro_racemase PF05544.11 ETO31291.1 - 2.8e-14 52.9 0.0 3.4e-14 52.6 0.0 1.0 1 0 0 1 1 1 1 Proline racemase GIT_CC PF16559.5 ETO31292.1 - 0.095 12.6 3.0 8.2 6.4 2.6 2.2 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor DUF5003 PF16394.5 ETO31292.1 - 0.11 11.7 1.9 0.14 11.3 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5003) Tmemb_cc2 PF10267.9 ETO31292.1 - 0.42 9.7 8.5 1.5 7.8 8.6 1.7 1 1 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Phage_Mu_Gam PF07352.12 ETO31292.1 - 0.73 9.7 10.8 0.73 9.7 7.5 2.1 2 1 0 2 2 2 0 Bacteriophage Mu Gam like protein RIC3 PF15361.6 ETO31292.1 - 1.7 9.0 5.5 3 8.2 5.5 1.3 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Methyltransf_16 PF10294.9 ETO31293.1 - 0.025 14.3 0.4 0.044 13.5 0.4 1.5 1 0 0 1 1 1 0 Lysine methyltransferase Ustilago_mating PF05722.12 ETO31293.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 Ustilago B locus mating-type protein DUF3091 PF11291.8 ETO31294.1 - 0.034 14.3 1.2 0.088 13.0 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3091) DUF1126 PF06565.12 ETO31295.1 - 0.1 12.5 2.8 2.1 8.2 1.0 2.6 2 1 0 2 2 2 0 DUF1126 PH-like domain bZIP_2 PF07716.15 ETO31295.1 - 0.13 12.3 0.6 0.28 11.3 0.6 1.5 1 0 0 1 1 1 0 Basic region leucine zipper Mucin PF01456.17 ETO31297.1 - 0.18 11.8 22.3 0.087 12.8 10.2 2.6 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF853 PF05872.12 ETO31297.1 - 0.2 10.2 2.1 0.27 9.8 2.1 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) DUF3439 PF11921.8 ETO31297.1 - 6.4 6.8 17.5 0.056 13.4 6.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) WD40 PF00400.32 ETO31298.1 - 1.2e-06 29.1 4.1 0.005 17.7 0.3 3.5 3 2 0 3 3 3 2 WD domain, G-beta repeat 2OG-FeII_Oxy_3 PF13640.6 ETO31301.1 - 9.8e-10 39.2 0.0 2.4e-09 38.0 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 ETO31301.1 - 2.9e-05 23.7 0.0 6.8e-05 22.5 0.0 1.7 1 1 0 1 1 1 1 Oxygenase, catalysing oxidative methylation of damaged DNA 2OG-FeII_Oxy_4 PF13661.6 ETO31301.1 - 0.073 13.7 0.0 0.28 11.8 0.0 2.0 1 1 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Ras PF00071.22 ETO31302.1 - 3.6e-28 98.2 1.3 7.3e-17 61.4 0.1 2.2 1 1 0 2 2 2 2 Ras family Roc PF08477.13 ETO31302.1 - 7.3e-24 84.3 0.5 3.4e-13 49.9 0.0 2.3 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO31302.1 - 1.7e-05 24.4 0.0 0.0069 15.9 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO31302.1 - 0.0051 16.9 0.0 1.8 8.7 0.0 2.1 2 0 0 2 2 2 2 50S ribosome-binding GTPase TniB PF05621.11 ETO31302.1 - 0.033 13.6 0.0 0.039 13.3 0.0 1.1 1 0 0 1 1 1 0 Bacterial TniB protein Gtr1_RagA PF04670.12 ETO31302.1 - 0.078 12.3 0.5 1.3 8.3 0.1 2.1 2 0 0 2 2 2 0 Gtr1/RagA G protein conserved region R3H PF01424.22 ETO31303.1 - 1.4e-08 34.6 1.4 3.4e-08 33.3 0.1 2.4 2 0 0 2 2 2 1 R3H domain DUF3437 PF11919.8 ETO31304.1 - 0.014 15.3 3.5 0.14 12.1 0.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) Sec62 PF03839.16 ETO31305.1 - 0.003 17.1 0.1 0.003 17.1 0.1 2.3 2 0 0 2 2 2 1 Translocation protein Sec62 DUF2207 PF09972.9 ETO31305.1 - 0.082 11.7 0.3 0.12 11.1 0.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Orf78 PF06024.12 ETO31305.1 - 0.53 10.6 4.8 1.3 9.4 3.3 2.4 1 1 1 2 2 2 0 Orf78 (ac78) Tyrosinase PF00264.20 ETO31305.1 - 0.73 10.1 9.1 0.63 10.3 7.4 1.7 1 1 0 1 1 1 0 Common central domain of tyrosinase TetR_C_11 PF16859.5 ETO31306.1 - 0.047 14.0 2.6 0.048 14.0 0.7 2.0 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain zf-C2HC5 PF06221.13 ETO31307.1 - 1.4e-12 47.4 8.4 2.5e-12 46.6 8.4 1.5 1 0 0 1 1 1 1 Putative zinc finger motif, C2HC5-type ASCH PF04266.14 ETO31307.1 - 9.8e-11 42.2 0.0 3.7e-10 40.3 0.0 2.0 1 0 0 1 1 1 1 ASCH domain zinc_ribbon_2 PF13240.6 ETO31307.1 - 2.9 7.7 7.0 12 5.8 7.0 2.2 1 1 0 1 1 1 0 zinc-ribbon domain ubiquitin PF00240.23 ETO31308.1 - 5e-12 45.4 0.2 8.8e-12 44.6 0.2 1.4 1 0 0 1 1 1 1 Ubiquitin family Ubiquitin_4 PF18036.1 ETO31308.1 - 1.9e-06 27.8 0.1 5.4e-06 26.4 0.0 1.7 1 1 1 2 2 2 1 Ubiquitin-like domain Rad60-SLD PF11976.8 ETO31308.1 - 3.8e-05 23.4 0.1 7.5e-05 22.5 0.1 1.4 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like TBK1_ULD PF18396.1 ETO31308.1 - 0.016 15.1 0.1 0.034 14.1 0.1 1.5 1 0 0 1 1 1 0 TANK binding kinase 1 ubiquitin-like domain Ubiquitin_2 PF14560.6 ETO31308.1 - 0.071 13.6 0.1 0.12 12.8 0.1 1.3 1 0 0 1 1 1 0 Ubiquitin-like domain Lum_binding PF00677.17 ETO31308.1 - 0.15 12.1 0.1 0.26 11.3 0.1 1.5 1 0 0 1 1 1 0 Lumazine binding domain DUF1173 PF06666.11 ETO31308.1 - 0.19 10.6 0.0 0.26 10.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1173) SLATT_5 PF18160.1 ETO31309.1 - 0.0019 17.5 0.2 0.0031 16.8 0.2 1.3 1 0 0 1 1 1 1 SMODS and SLOG-associating 2TM effector domain family 5 SpoIIM PF01944.17 ETO31309.1 - 0.0081 16.2 0.8 0.011 15.8 0.8 1.2 1 0 0 1 1 1 1 Stage II sporulation protein M FlaC_arch PF05377.11 ETO31310.1 - 2.6 8.5 17.0 0.93 9.9 0.2 4.7 4 2 2 6 6 6 0 Flagella accessory protein C (FlaC) GIT_CC PF16559.5 ETO31310.1 - 5.1 7.0 18.4 0.069 13.0 3.7 4.0 4 0 0 4 4 4 0 GIT coiled-coil Rho guanine nucleotide exchange factor MINDY_DUB PF04424.13 ETO31311.1 - 6.9e-19 68.0 0.3 1.1e-17 64.1 0.1 2.5 2 0 0 2 2 2 1 MINDY deubiquitinase Caskin-tail PF16632.5 ETO31312.1 - 0.077 13.4 1.4 3.6 8.1 0.1 3.4 2 1 0 2 2 2 0 C-terminal region of Caskin DUSP PF06337.12 ETO31313.1 - 0.0029 18.2 0.2 0.044 14.4 0.0 2.2 2 0 0 2 2 2 1 DUSP domain Ac76 PF05814.11 ETO31313.1 - 0.029 14.4 0.1 0.068 13.2 0.1 1.6 1 0 0 1 1 1 0 Orf76 (Ac76) SAM_1 PF00536.30 ETO31314.1 - 0.0041 17.5 0.1 3.4 8.2 0.0 3.0 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) NACHT PF05729.12 ETO31315.1 - 1e-16 61.3 0.0 9e-16 58.2 0.0 2.2 1 1 0 1 1 1 1 NACHT domain AAA_16 PF13191.6 ETO31315.1 - 9.4e-06 26.1 0.0 3.9e-05 24.1 0.0 2.0 3 0 0 3 3 3 1 AAA ATPase domain DUF2154 PF09922.9 ETO31315.1 - 0.00029 20.7 0.1 0.00097 19.0 0.1 1.8 1 0 0 1 1 1 1 Cell wall-active antibiotics response 4TMS YvqF AAA_22 PF13401.6 ETO31315.1 - 0.0011 19.3 0.0 0.038 14.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ETO31315.1 - 0.0012 18.1 0.0 0.037 13.2 0.0 2.7 3 0 0 3 3 3 1 NB-ARC domain DAP3 PF10236.9 ETO31315.1 - 0.0055 15.9 0.0 0.0099 15.1 0.0 1.4 1 0 0 1 1 1 1 Mitochondrial ribosomal death-associated protein 3 Torsin PF06309.11 ETO31315.1 - 0.0094 16.0 0.0 0.032 14.3 0.0 1.9 2 0 0 2 2 2 1 Torsin DUF1251 PF06856.11 ETO31315.1 - 0.11 12.3 0.2 0.32 10.7 0.0 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF1251) Cwf_Cwc_15 PF04889.12 ETO31315.1 - 0.86 9.3 17.3 0.1 12.3 7.3 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein RNA_pol_3_Rpc31 PF11705.8 ETO31315.1 - 4.5 7.5 24.2 0.033 14.4 9.8 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 MPP6 PF10175.9 ETO31315.1 - 8.2 6.9 17.5 0.063 13.8 3.4 3.1 3 0 0 3 3 3 0 M-phase phosphoprotein 6 ResIII PF04851.15 ETO31315.1 - 9.1 6.2 9.0 2.1 8.3 0.0 3.1 3 1 1 4 4 4 0 Type III restriction enzyme, res subunit DUF2457 PF10446.9 ETO31315.1 - 9.2 5.3 19.6 0.021 14.0 9.6 1.6 2 0 0 2 2 1 0 Protein of unknown function (DUF2457) NLRC4_HD2 PF17776.1 ETO31316.1 - 0.0037 17.8 0.4 0.0077 16.8 0.1 1.9 2 1 0 2 2 2 1 NLRC4 helical domain HD2 HEAT_2 PF13646.6 ETO31317.1 - 0.0024 18.2 0.0 1 9.8 0.0 2.4 2 0 0 2 2 2 2 HEAT repeats TAN PF11640.8 ETO31317.1 - 0.025 14.7 0.2 15 5.7 0.0 3.3 1 1 2 3 3 3 0 Telomere-length maintenance and DNA damage repair DUF3826 PF12875.7 ETO31317.1 - 0.12 12.5 0.1 2.6 8.1 0.1 2.7 2 1 0 2 2 2 0 Protein of unknown function (DUF3826) Ank_3 PF13606.6 ETO31318.1 - 1.8e-05 24.8 3.0 0.026 15.0 0.0 3.7 4 0 0 4 4 4 2 Ankyrin repeat Ank_2 PF12796.7 ETO31318.1 - 0.0001 22.8 0.3 0.0013 19.3 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) HEAT_2 PF13646.6 ETO31318.1 - 0.0028 18.0 0.0 0.016 15.6 0.0 2.3 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO31318.1 - 0.0034 17.5 0.0 0.031 14.5 0.0 2.7 2 0 0 2 2 2 1 HEAT repeat Ank_4 PF13637.6 ETO31318.1 - 0.0049 17.4 1.2 0.014 16.0 0.1 2.4 2 1 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO31318.1 - 0.0078 16.5 0.2 0.036 14.4 0.2 2.2 1 1 1 2 2 2 1 Ankyrin repeats (many copies) HEAT_EZ PF13513.6 ETO31318.1 - 0.015 15.8 0.0 0.047 14.2 0.0 1.9 1 0 0 1 1 1 0 HEAT-like repeat Ank PF00023.30 ETO31318.1 - 0.12 12.9 0.0 0.54 10.8 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeat Cnd1 PF12717.7 ETO31318.1 - 0.47 10.5 3.7 0.26 11.3 0.5 2.3 3 1 0 3 3 3 0 non-SMC mitotic condensation complex subunit 1 TPR_12 PF13424.6 ETO31319.1 - 7.1e-06 26.2 0.8 0.013 15.8 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31319.1 - 0.00042 20.2 0.5 0.98 9.7 0.1 2.9 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31319.1 - 0.00078 20.0 0.2 0.0015 19.1 0.2 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO31319.1 - 0.0011 19.2 0.1 0.031 14.6 0.1 3.0 3 0 0 3 3 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31319.1 - 0.0043 16.7 1.1 0.12 12.1 0.1 2.5 1 1 1 2 2 2 1 TPR repeat TPR_1 PF00515.28 ETO31319.1 - 0.0044 16.8 0.8 2.6 8.0 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat CCDC53 PF10152.9 ETO31319.1 - 0.0056 17.1 1.0 0.011 16.2 1.0 1.4 1 0 0 1 1 1 1 Subunit CCDC53 of WASH complex DUF4637 PF15470.6 ETO31319.1 - 0.07 12.9 3.0 0.14 11.9 3.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TPR_8 PF13181.6 ETO31319.1 - 0.093 13.0 0.6 7.9 7.0 0.1 3.0 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF5523 PF17661.1 ETO31319.1 - 0.12 12.1 11.3 0.29 10.8 11.3 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Zip PF02535.22 ETO31319.1 - 0.57 9.3 2.7 0.76 8.9 2.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter YqfQ PF14181.6 ETO31319.1 - 1.1 9.5 8.0 2 8.6 8.0 1.4 1 0 0 1 1 1 0 YqfQ-like protein Presenilin PF01080.17 ETO31319.1 - 1.1 8.0 5.5 1.7 7.4 5.5 1.2 1 0 0 1 1 1 0 Presenilin DDHD PF02862.17 ETO31319.1 - 1.2 9.3 9.2 1.3 9.2 8.2 1.5 1 1 0 1 1 1 0 DDHD domain TPR_2 PF07719.17 ETO31323.1 - 8.7e-23 78.6 9.0 0.0017 18.4 0.1 8.0 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31323.1 - 1.5e-19 68.9 15.0 0.001 18.8 0.0 7.2 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO31323.1 - 2.8e-17 62.7 7.2 8.9e-05 22.7 0.0 6.4 4 2 1 6 6 6 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31323.1 - 1.9e-15 56.2 0.3 0.00037 21.1 0.0 6.3 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO31323.1 - 3.5e-11 43.5 1.7 0.08 13.5 0.0 5.8 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31323.1 - 1e-10 41.0 5.5 0.1 12.9 0.0 6.5 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31323.1 - 7.1e-10 39.4 0.0 0.0064 17.1 0.0 5.1 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO31323.1 - 2.2e-08 34.2 1.7 0.088 13.5 0.3 5.1 5 0 0 5 5 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO31323.1 - 5.5e-07 29.7 18.8 0.0064 16.7 0.4 6.4 4 2 3 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_17 PF13431.6 ETO31323.1 - 3.3e-06 27.1 11.0 0.0031 17.8 0.0 6.2 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31323.1 - 1.2e-05 25.0 3.8 7.1 6.9 0.2 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat SRP_TPR_like PF17004.5 ETO31323.1 - 2.1e-05 24.5 0.6 0.0005 20.1 0.7 2.6 2 0 0 2 2 2 1 Putative TPR-like repeat Fis1_TPR_C PF14853.6 ETO31323.1 - 4e-05 23.6 0.1 1.4 9.1 0.0 4.6 5 0 0 5 5 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_10 PF13374.6 ETO31323.1 - 0.0024 17.7 0.9 11 6.1 0.0 4.5 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31323.1 - 0.0096 15.6 7.6 0.048 13.3 0.0 3.9 5 1 0 5 5 5 1 TPR repeat PPR_2 PF13041.6 ETO31324.1 - 3.8e-14 52.6 10.3 4.1e-08 33.3 0.6 4.2 2 1 2 4 4 4 4 PPR repeat family PPR PF01535.20 ETO31324.1 - 1.5e-13 50.0 7.7 0.0019 18.3 0.1 4.6 4 0 0 4 4 4 4 PPR repeat PPR_long PF17177.4 ETO31324.1 - 8.1e-12 45.0 0.1 1.3e-11 44.3 0.1 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 ETO31324.1 - 7.6e-09 35.5 4.0 2.8e-06 27.3 0.2 3.1 1 1 2 3 3 3 3 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO31324.1 - 2.8e-06 26.9 0.4 0.053 13.2 0.0 3.4 3 0 0 3 3 3 2 PPR repeat ATP13 PF12921.7 ETO31324.1 - 0.0035 17.2 1.1 0.045 13.6 0.4 2.7 1 1 1 2 2 2 1 Mitochondrial ATPase expression DUF3636 PF12331.8 ETO31324.1 - 0.035 14.0 0.1 0.081 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3636) DUF5072 PF16807.5 ETO31324.1 - 0.058 13.5 0.2 0.19 11.8 0.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF5072) zf-TRAF PF02176.18 ETO31325.1 - 3.6e-06 27.6 0.4 3.6e-06 27.6 0.4 2.7 3 1 0 3 3 3 1 TRAF-type zinc finger GCV_H PF01597.19 ETO31325.1 - 0.17 11.7 0.0 2.1 8.3 0.0 2.1 2 0 0 2 2 2 0 Glycine cleavage H-protein zf-P11 PF03854.14 ETO31325.1 - 0.94 9.2 0.1 0.94 9.2 0.1 3.1 3 0 0 3 3 3 0 P-11 zinc finger ECH_1 PF00378.20 ETO31326.1 - 3.1e-56 190.5 0.0 3.7e-56 190.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO31326.1 - 7e-26 91.5 0.0 8.7e-26 91.2 0.0 1.1 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase Epimerase_2 PF02350.19 ETO31326.1 - 0.16 10.8 0.1 0.37 9.6 0.0 1.5 2 0 0 2 2 2 0 UDP-N-acetylglucosamine 2-epimerase PTPlike_phytase PF14566.6 ETO31327.1 - 1.1e-27 97.1 0.1 1.1e-27 97.1 0.1 2.5 4 0 0 4 4 4 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ETO31327.1 - 0.0029 17.6 0.6 0.023 14.7 0.7 2.4 3 1 0 3 3 3 1 Tyrosine phosphatase family SPATA9 PF15824.5 ETO31327.1 - 0.26 10.5 1.8 0.39 10.0 0.2 2.0 2 0 0 2 2 2 0 Spermatogenesis-associated protein 9 SSP160 PF06933.11 ETO31327.1 - 2 6.5 19.7 2.9 6.0 19.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Mucin PF01456.17 ETO31327.1 - 2.9 7.9 29.1 5.4 7.0 29.1 1.3 1 0 0 1 1 1 0 Mucin-like glycoprotein 7tm_3 PF00003.22 ETO31328.1 - 1.4e-20 74.0 33.8 1.4e-20 74.0 33.8 1.3 1 1 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DDHD PF02862.17 ETO31329.1 - 0.096 12.8 8.7 0.97 9.6 8.3 2.1 2 0 0 2 2 2 0 DDHD domain DUF4746 PF15928.5 ETO31329.1 - 1.1 8.6 5.2 2 7.8 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Menin PF05053.13 ETO31329.1 - 4.2 5.6 11.2 6.4 5.0 11.2 1.2 1 0 0 1 1 1 0 Menin FA_hydroxylase PF04116.13 ETO31329.1 - 4.3 7.7 18.1 3 8.2 7.3 3.2 3 0 0 3 3 3 0 Fatty acid hydroxylase superfamily Neur_chan_memb PF02932.16 ETO31329.1 - 9.1 6.3 6.4 67 3.4 5.5 2.2 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.6 ETO31330.1 - 0.05 13.6 3.3 0.056 13.4 3.3 1.2 1 0 0 1 1 1 0 Protein Family FAM60A RMI1_N PF08585.12 ETO31330.1 - 0.93 9.2 6.7 1.4 8.6 6.7 1.2 1 0 0 1 1 1 0 RecQ mediated genome instability protein SLC12 PF03522.15 ETO31330.1 - 4 6.4 10.2 4.3 6.3 10.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PNISR PF15996.5 ETO31330.1 - 4.3 7.6 11.2 5.4 7.3 11.2 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Transket_pyr PF02779.24 ETO31331.1 - 1.8e-53 180.8 0.0 2.9e-53 180.2 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ETO31331.1 - 9.6e-51 172.5 0.2 1.3e-50 172.1 0.2 1.2 1 0 0 1 1 1 1 Dehydrogenase E1 component DUF507 PF04368.13 ETO31331.1 - 0.063 13.2 0.1 0.1 12.5 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF507) Cpn60_TCP1 PF00118.24 ETO31332.1 - 5.5e-68 229.8 5.3 3.7e-67 227.1 5.3 1.9 1 1 0 1 1 1 1 TCP-1/cpn60 chaperonin family Alk_phosphatase PF00245.20 ETO31332.1 - 0.0084 15.1 0.1 0.18 10.7 0.0 2.1 2 0 0 2 2 2 1 Alkaline phosphatase PPO1_KFDV PF12143.8 ETO31332.1 - 0.05 13.7 0.1 0.15 12.2 0.1 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF_B2219) NARP1 PF12569.8 ETO31333.1 - 1.7e-07 30.6 4.8 4e-05 22.7 0.3 2.4 2 1 0 2 2 2 2 NMDA receptor-regulated protein 1 TPR_2 PF07719.17 ETO31333.1 - 4.4e-07 29.5 4.2 0.0033 17.4 0.0 5.2 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31333.1 - 0.00012 21.6 9.8 0.098 12.4 0.6 3.8 4 0 0 4 4 4 2 TPR repeat TPR_19 PF14559.6 ETO31333.1 - 0.0006 20.3 2.7 6.1 7.4 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31333.1 - 0.00062 19.5 4.4 0.026 14.3 0.0 4.4 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31333.1 - 0.0021 18.7 0.6 26 6.0 0.0 4.7 3 2 2 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31333.1 - 0.0023 18.5 0.0 3 8.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31333.1 - 0.0039 17.3 1.2 27 5.3 0.0 4.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO31333.1 - 0.0089 16.3 0.1 0.19 12.0 0.0 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO31333.1 - 0.0091 16.6 2.8 43 5.1 0.1 4.5 4 0 0 4 4 4 0 Tetratricopeptide repeat MOR2-PAG1_C PF14225.6 ETO31333.1 - 0.01 15.7 0.4 0.037 13.9 0.3 1.9 2 0 0 2 2 2 0 Cell morphogenesis C-terminal PP2C PF00481.21 ETO31335.1 - 5.1e-32 111.5 2.4 2.6e-25 89.5 0.4 2.2 1 1 1 2 2 2 2 Protein phosphatase 2C Pox_Ag35 PF03286.14 ETO31335.1 - 0.026 14.3 9.1 0.05 13.4 9.1 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DDHD PF02862.17 ETO31335.1 - 0.042 14.0 0.2 0.054 13.7 0.2 1.2 1 0 0 1 1 1 0 DDHD domain Ferlin_C PF16165.5 ETO31335.1 - 0.065 13.2 2.9 0.14 12.1 2.9 1.5 1 0 0 1 1 1 0 Ferlin C-terminus SpoIIE PF07228.12 ETO31335.1 - 0.068 13.1 0.0 0.29 11.0 0.0 2.0 2 0 0 2 2 2 0 Stage II sporulation protein E (SpoIIE) FAM176 PF14851.6 ETO31335.1 - 0.56 9.9 4.7 1 9.0 4.7 1.4 1 0 0 1 1 1 0 FAM176 family DUF4820 PF16091.5 ETO31335.1 - 0.63 9.4 7.1 0.88 8.9 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PWWP PF00855.17 ETO31335.1 - 0.96 9.9 6.7 0.21 12.0 2.2 2.2 2 1 1 3 3 3 0 PWWP domain Presenilin PF01080.17 ETO31335.1 - 1.6 7.4 3.2 1.9 7.2 3.2 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO31335.1 - 3 6.5 7.5 4.1 6.1 7.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BTB_3 PF16017.5 ETO31337.1 - 0.1 12.7 0.0 0.18 11.9 0.0 1.4 1 0 0 1 1 1 0 BTB/POZ domain NACHT PF05729.12 ETO31338.1 - 0.004 17.1 0.1 0.0088 16.0 0.0 1.6 2 0 0 2 2 2 1 NACHT domain DUF908 PF06012.12 ETO31338.1 - 0.0098 15.3 0.0 0.011 15.2 0.0 1.2 1 0 0 1 1 1 1 Domain of Unknown Function (DUF908) NB-ARC PF00931.22 ETO31338.1 - 0.015 14.5 1.5 0.78 8.9 0.0 2.4 2 1 0 2 2 2 0 NB-ARC domain ATP-synt_E PF05680.12 ETO31338.1 - 4 7.9 6.6 4 7.9 2.4 2.2 2 0 0 2 2 2 0 ATP synthase E chain FDF PF09532.10 ETO31339.1 - 1.1 10.2 16.4 1.2 10.1 16.4 1.0 1 0 0 1 1 1 0 FDF domain Nop53 PF07767.11 ETO31341.1 - 1.9 7.8 38.3 1.9 7.8 38.3 1.0 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) CDC45 PF02724.14 ETO31341.1 - 7.4 4.7 30.5 8.2 4.6 30.5 1.0 1 0 0 1 1 1 0 CDC45-like protein DUF2052 PF09747.9 ETO31341.1 - 8.4 6.5 23.4 10 6.2 23.4 1.0 1 0 0 1 1 1 0 Coiled-coil domain containing protein (DUF2052) Acetyltransf_1 PF00583.25 ETO31342.1 - 5.4e-08 33.1 0.2 7.9e-08 32.5 0.2 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_10 PF13673.7 ETO31342.1 - 2.4e-07 30.8 0.1 4.1e-07 30.0 0.1 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO31342.1 - 1e-05 25.8 0.5 1.9e-05 25.0 0.5 1.5 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain FR47 PF08445.10 ETO31342.1 - 0.0051 16.8 0.0 0.0078 16.2 0.0 1.3 1 0 0 1 1 1 1 FR47-like protein Acetyltransf_4 PF13420.7 ETO31342.1 - 0.047 13.8 0.7 0.44 10.7 0.1 2.0 1 1 1 2 2 2 0 Acetyltransferase (GNAT) domain Adeno_E3_CR2 PF02439.15 ETO31342.1 - 1.6 8.5 8.8 2.7 7.8 8.8 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 Adaptin_N PF01602.20 ETO31343.1 - 7.5e-54 183.2 3.0 8.7e-54 182.9 3.0 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO31343.1 - 5e-19 68.9 2.4 2.9e-18 66.4 0.2 2.2 2 1 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO31343.1 - 3.8e-08 32.9 1.5 0.46 10.9 0.0 4.3 5 0 0 5 5 5 3 HEAT repeat HEAT_2 PF13646.6 ETO31343.1 - 1.8e-05 25.0 0.8 0.0008 19.8 0.2 3.1 2 1 0 3 3 3 1 HEAT repeats GUN4_N PF16416.5 ETO31343.1 - 0.0096 15.9 0.1 0.03 14.3 0.0 1.8 2 0 0 2 2 2 1 ARM-like repeat domain, GUN4-N terminal KBP_C PF12309.8 ETO31343.1 - 0.018 14.6 0.2 0.024 14.2 0.2 1.1 1 0 0 1 1 1 0 KIF-1 binding protein C terminal DUF5109 PF17134.4 ETO31343.1 - 0.018 14.9 0.2 0.076 12.9 0.1 2.1 2 1 1 3 3 3 0 Domain of unknown function (DUF5109) TIP120 PF08623.10 ETO31343.1 - 0.051 13.3 0.5 0.15 11.8 0.3 1.8 1 1 0 1 1 1 0 TATA-binding protein interacting (TIP20) NUDIX_4 PF14815.6 ETO31344.1 - 6.6e-10 39.0 0.0 1.1e-09 38.3 0.0 1.4 1 0 0 1 1 1 1 NUDIX domain HhH-GPD PF00730.25 ETO31345.1 - 2.5e-15 56.9 0.1 2.1e-06 28.1 0.0 2.7 2 0 0 2 2 2 2 HhH-GPD superfamily base excision DNA repair protein HHH PF00633.23 ETO31345.1 - 0.00015 21.4 0.0 0.00037 20.2 0.0 1.7 1 0 0 1 1 1 1 Helix-hairpin-helix motif EndIII_4Fe-2S PF10576.9 ETO31345.1 - 0.0019 18.5 5.9 0.0043 17.4 5.9 1.6 1 0 0 1 1 1 1 Iron-sulfur binding domain of endonuclease III ALMT PF11744.8 ETO31345.1 - 0.011 14.6 4.7 0.019 13.8 4.7 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF1823 PF08853.11 ETO31345.1 - 0.035 14.3 0.0 0.69 10.1 0.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1823) Whib PF02467.16 ETO31345.1 - 0.81 10.3 4.5 0.32 11.6 0.8 2.3 2 0 0 2 2 2 0 Transcription factor WhiB F_actin_cap_B PF01115.17 ETO31346.1 - 2.3e-10 40.5 0.2 4.5e-10 39.6 0.2 1.5 1 1 0 1 1 1 1 F-actin capping protein, beta subunit DUF5064 PF16703.5 ETO31347.1 - 0.017 15.6 0.1 0.21 12.1 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5064) HSBP1 PF06825.12 ETO31347.1 - 0.065 13.1 0.3 0.2 11.6 0.1 2.0 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Beta_lactamase3 PF17030.5 ETO31348.1 - 1.3e-05 24.5 0.0 1.7e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Putative beta-lactamase-like family Lactamase_B_6 PF16661.5 ETO31348.1 - 0.0026 17.2 0.0 0.0037 16.7 0.0 1.2 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily domain PI3_PI4_kinase PF00454.27 ETO31349.1 - 4.1e-09 36.6 0.0 6.6e-08 32.7 0.0 2.5 2 0 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase DUF2542 PF10808.8 ETO31349.1 - 0.17 12.4 0.2 0.17 12.4 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2542) WD40 PF00400.32 ETO31350.1 - 0.00086 20.1 2.9 1.4 9.9 0.1 3.7 3 1 0 3 3 3 2 WD domain, G-beta repeat MMR_HSR1 PF01926.23 ETO31352.1 - 3.5e-05 23.8 0.1 0.00031 20.8 0.1 2.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO31352.1 - 3.7e-05 23.7 0.8 0.00059 19.8 0.8 3.3 1 1 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ETO31352.1 - 0.0009 19.8 0.1 0.0009 19.8 0.1 3.8 3 1 0 3 3 3 1 ABC transporter AAA_29 PF13555.6 ETO31352.1 - 0.017 14.9 0.1 0.037 13.8 0.1 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF1192 PF06698.11 ETO31352.1 - 0.035 14.2 0.6 19 5.4 0.0 4.3 3 0 0 3 3 3 0 Protein of unknown function (DUF1192) Zn_protease PF05618.11 ETO31352.1 - 0.047 13.6 0.3 0.23 11.3 0.3 2.2 1 0 0 1 1 1 0 Putative ATP-dependant zinc protease T2SSE PF00437.20 ETO31352.1 - 0.065 12.3 0.1 0.19 10.7 0.1 1.8 1 0 0 1 1 1 0 Type II/IV secretion system protein SesA PF17107.5 ETO31352.1 - 1 9.5 17.0 0.64 10.2 0.5 5.6 5 0 0 5 5 5 0 N-terminal domain on NACHT_NTPase and P-loop NTPases AAA_18 PF13238.6 ETO31352.1 - 6.3 7.4 17.2 20 5.7 0.1 5.9 4 1 1 5 5 5 0 AAA domain PT PF04886.12 ETO31353.1 - 6.1e-77 252.9 312.7 6.4e-05 22.4 21.2 19.2 1 1 7 8 8 8 6 PT repeat Med31 PF05669.12 ETO31354.1 - 0.06 13.4 0.0 0.18 11.8 0.0 1.8 1 0 0 1 1 1 0 SOH1 GPS PF01825.21 ETO31355.1 - 0.0093 16.5 2.7 0.024 15.1 2.7 1.7 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif GAIN PF16489.5 ETO31355.1 - 0.035 13.5 0.4 0.085 12.3 0.4 1.6 1 0 0 1 1 1 0 GPCR-Autoproteolysis INducing (GAIN) domain DUF2207 PF09972.9 ETO31356.1 - 0.01 14.6 0.0 0.01 14.6 0.0 2.1 2 1 0 2 2 2 0 Predicted membrane protein (DUF2207) WD40 PF00400.32 ETO31357.1 - 1.7e-47 158.4 7.1 1.2e-10 41.7 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31357.1 - 2.7e-18 66.0 2.1 7.2e-05 23.0 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31357.1 - 6.1e-17 61.6 0.4 0.053 12.5 0.0 5.0 2 2 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO31357.1 - 1.3e-08 34.9 0.7 7.8e-05 22.6 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO31357.1 - 6.9e-07 29.0 1.7 0.097 12.6 0.1 4.5 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO31357.1 - 9.9e-05 21.2 5.7 3.1 6.3 0.0 5.0 2 2 3 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO31357.1 - 0.0047 15.7 4.4 0.39 9.4 0.1 3.4 2 1 2 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 ETO31357.1 - 0.0085 15.4 1.1 4 6.7 0.2 2.6 2 1 1 3 3 3 3 WD40-like domain SGL PF08450.12 ETO31357.1 - 0.014 15.0 0.1 0.81 9.2 0.0 3.1 1 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region HARP PF07443.13 ETO31357.1 - 0.022 14.4 0.1 2.3 7.9 0.0 3.6 4 0 0 4 4 4 0 HepA-related protein (HARP) UCH_1 PF13423.6 ETO31358.1 - 3.9e-06 26.7 0.0 3.9e-06 26.7 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Retinal PF15449.6 ETO31359.1 - 0.00023 19.1 35.0 0.0056 14.5 18.5 2.1 1 1 1 2 2 2 2 Retinal protein T3SchapCesA PF11439.8 ETO31359.1 - 0.12 12.6 0.1 8.1 6.7 0.0 2.4 2 0 0 2 2 2 0 Type III secretion system filament chaperone CesA Ndc1_Nup PF09531.10 ETO31359.1 - 4 6.0 8.6 4.6 5.8 8.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup ING PF12998.7 ETO31360.1 - 0.014 16.0 5.7 0.027 15.0 5.5 1.6 1 1 0 1 1 1 0 Inhibitor of growth proteins N-terminal histone-binding DUF948 PF06103.11 ETO31360.1 - 0.041 14.1 1.0 5 7.5 0.0 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Tweety PF04906.13 ETO31361.1 - 1e-05 24.4 5.0 2.3e-05 23.2 5.0 1.5 1 0 0 1 1 1 1 Tweety HSP9_HSP12 PF04119.12 ETO31361.1 - 0.084 13.3 0.1 0.18 12.2 0.1 1.6 1 0 0 1 1 1 0 Heat shock protein 9/12 LMBR1 PF04791.16 ETO31362.1 - 5.5e-46 157.5 6.7 5.5e-46 157.5 6.7 1.8 2 0 0 2 2 2 1 LMBR1-like membrane protein RAP PF08373.10 ETO31362.1 - 0.015 15.4 1.4 4.5 7.5 0.0 2.7 2 0 0 2 2 2 0 RAP domain CENP-B_dimeris PF09026.10 ETO31362.1 - 0.05 14.0 6.5 0.13 12.7 6.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain FAM176 PF14851.6 ETO31362.1 - 0.055 13.1 6.5 0.22 11.2 5.2 2.3 2 0 0 2 2 2 0 FAM176 family RXT2_N PF08595.11 ETO31362.1 - 0.061 13.4 8.9 0.17 11.9 8.9 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal Pox_Ag35 PF03286.14 ETO31362.1 - 0.48 10.2 17.5 0.071 12.9 6.6 2.5 3 0 0 3 3 3 0 Pox virus Ag35 surface protein NOA36 PF06524.12 ETO31362.1 - 0.51 9.6 11.4 0.92 8.8 11.4 1.3 1 0 0 1 1 1 0 NOA36 protein Afi1 PF07792.12 ETO31362.1 - 1.5 9.3 18.5 0.31 11.5 9.4 2.7 3 0 0 3 3 3 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FAM60A PF15396.6 ETO31362.1 - 2.9 7.8 11.1 0.71 9.8 2.1 2.4 2 0 0 2 2 2 0 Protein Family FAM60A CPSF100_C PF13299.6 ETO31362.1 - 7.9 6.6 10.1 2.1 8.5 1.6 2.8 2 1 1 3 3 3 0 Cleavage and polyadenylation factor 2 C-terminal EphA2_TM PF14575.6 ETO31363.1 - 0.00041 21.2 0.0 0.00078 20.3 0.0 1.4 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Cyto_heme_lyase PF01265.17 ETO31363.1 - 0.006 16.2 0.5 0.0078 15.8 0.5 1.1 1 0 0 1 1 1 1 Cytochrome c/c1 heme lyase WBP-1 PF11669.8 ETO31363.1 - 0.053 14.1 0.1 0.11 13.1 0.1 1.5 1 0 0 1 1 1 0 WW domain-binding protein 1 Syndecan PF01034.20 ETO31363.1 - 0.077 12.9 0.8 0.18 11.7 0.1 1.9 2 0 0 2 2 2 0 Syndecan domain ETRAMP PF09716.10 ETO31363.1 - 0.12 12.4 2.5 0.22 11.6 2.5 1.3 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) eIF3_p135 PF12807.7 ETO31364.1 - 0.063 13.3 0.1 0.083 12.9 0.1 1.2 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 Homez PF11569.8 ETO31364.1 - 0.077 12.5 0.1 0.17 11.4 0.1 1.5 1 0 0 1 1 1 0 Homeodomain leucine-zipper encoding, Homez RNA_pol_Rpb2_6 PF00562.28 ETO31366.1 - 5.1e-39 134.4 0.1 6.4e-39 134.1 0.1 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 ETO31366.1 - 1.5e-30 105.4 0.6 2.5e-30 104.7 0.6 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 SNARE PF05739.19 ETO31368.1 - 0.046 13.7 0.6 0.11 12.5 0.6 1.7 1 0 0 1 1 1 0 SNARE domain Streptin-Immun PF11083.8 ETO31368.1 - 2.4 8.6 11.2 0.33 11.4 1.5 2.8 2 1 0 2 2 2 0 Lantibiotic streptin immunity protein FlaC_arch PF05377.11 ETO31368.1 - 7.7 7.0 10.0 1.5 9.3 4.2 2.7 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) NPV_P10 PF05531.12 ETO31368.1 - 8.4 6.9 10.4 0.55 10.7 3.6 2.5 2 2 1 3 3 3 0 Nucleopolyhedrovirus P10 protein RGS PF00615.19 ETO31369.1 - 0.027 14.8 0.5 0.057 13.7 0.5 1.6 1 0 0 1 1 1 0 Regulator of G protein signaling domain RGS PF00615.19 ETO31371.1 - 0.03 14.6 0.7 4.2 7.7 0.2 2.5 2 1 0 2 2 2 0 Regulator of G protein signaling domain Zip PF02535.22 ETO31372.1 - 0.0026 17.1 0.6 0.0034 16.7 0.6 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter SelP_N PF04592.14 ETO31372.1 - 0.35 10.2 11.4 0.52 9.7 11.4 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region DUF3537 PF12056.8 ETO31372.1 - 1.4 7.6 15.6 0.24 10.2 3.9 2.9 1 1 2 3 3 3 0 Protein of unknown function (DUF3537) RNA_pol_Rpb2_6 PF00562.28 ETO31373.1 - 4.4e-90 302.6 0.0 5.9e-90 302.1 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_2 PF04561.14 ETO31373.1 - 3e-34 118.3 0.1 7.5e-34 117.0 0.1 1.7 1 1 0 1 1 1 1 RNA polymerase Rpb2, domain 2 RNA_pol_Rpb2_1 PF04563.15 ETO31373.1 - 4e-34 117.9 0.0 6.2e-34 117.3 0.0 1.2 1 0 0 1 1 1 1 RNA polymerase beta subunit RNA_pol_Rpb2_3 PF04565.16 ETO31373.1 - 2.9e-23 81.8 0.1 6.6e-23 80.7 0.1 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 RNA_pol_Rpb2_5 PF04567.17 ETO31373.1 - 8.9e-21 74.2 1.4 2.1e-20 73.0 1.4 1.7 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 5 RNA_pol_Rpb2_4 PF04566.13 ETO31373.1 - 4.4e-20 71.7 0.0 1.4e-19 70.1 0.0 2.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 4 zf-RING_2 PF13639.6 ETO31374.1 - 0.0004 20.6 12.3 0.0004 20.6 12.3 1.9 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ETO31374.1 - 0.00074 19.8 10.7 0.0015 18.7 10.7 1.6 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO31374.1 - 0.012 15.7 5.3 0.022 14.8 5.3 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ETO31374.1 - 0.029 14.1 7.9 0.029 14.1 7.9 1.9 2 0 0 2 2 2 0 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO31374.1 - 0.19 11.6 15.2 0.064 13.1 11.5 2.1 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_4 PF14570.6 ETO31374.1 - 0.56 10.0 12.6 0.22 11.3 9.4 2.1 1 1 1 2 2 2 0 RING/Ubox like zinc-binding domain Strumpellin PF10266.9 ETO31375.1 - 2.5e-52 177.9 0.2 2.9e-52 177.7 0.2 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin DUF4441 PF14536.6 ETO31375.1 - 0.14 12.4 2.5 0.32 11.2 2.3 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4441) Pkinase PF00069.25 ETO31376.1 - 2.5e-22 79.5 0.1 7.9e-19 68.0 0.0 2.3 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31376.1 - 0.00033 20.0 0.0 0.0012 18.1 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase DUF1201 PF06716.11 ETO31376.1 - 3.5 7.7 8.9 4.4 7.4 3.9 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF1201) Claudin_2 PF13903.6 ETO31377.1 - 0.12 12.1 0.2 0.19 11.5 0.2 1.3 1 0 0 1 1 1 0 PMP-22/EMP/MP20/Claudin tight junction Strumpellin PF10266.9 ETO31378.1 - 1.1e-33 116.2 0.0 1.2e-33 116.0 0.0 1.0 1 0 0 1 1 1 1 Hereditary spastic paraplegia protein strumpellin CCM2_C PF16545.5 ETO31378.1 - 0.039 14.5 0.0 0.066 13.8 0.0 1.3 1 0 0 1 1 1 0 Cerebral cavernous malformation protein, harmonin-homology EF-hand_1 PF00036.32 ETO31379.1 - 3.4e-05 23.1 0.4 3.4e-05 23.1 0.4 1.9 2 0 0 2 2 2 1 EF hand EF-hand_6 PF13405.6 ETO31379.1 - 0.00088 19.0 0.3 0.0021 17.9 0.3 1.6 1 0 0 1 1 1 1 EF-hand domain EF-hand_8 PF13833.6 ETO31379.1 - 0.0013 18.6 0.4 0.0025 17.6 0.4 1.5 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_7 PF13499.6 ETO31379.1 - 0.0023 18.3 0.2 0.0023 18.3 0.2 1.9 2 1 1 3 3 3 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO31379.1 - 0.006 16.0 0.2 0.015 14.8 0.2 1.7 1 0 0 1 1 1 1 EF hand EF-hand_4 PF12763.7 ETO31379.1 - 0.025 14.5 0.4 0.033 14.1 0.4 1.3 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Phostensin_N PF13916.6 ETO31379.1 - 0.038 14.3 0.1 0.078 13.3 0.1 1.5 1 0 0 1 1 1 0 PP1-regulatory protein, Phostensin N-terminal WD40 PF00400.32 ETO31380.1 - 9.1e-33 111.8 21.7 3.7e-05 24.4 0.3 8.2 8 1 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO31380.1 - 1.8e-06 26.9 4.6 1.5 7.3 0.0 5.0 2 2 3 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO31380.1 - 3.9e-06 27.1 2.9 0.77 10.1 0.0 5.3 5 1 1 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO31380.1 - 1.3e-05 25.7 1.4 4.9e-05 23.9 1.4 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger zf-RING-like PF08746.11 ETO31380.1 - 0.07 13.5 0.4 0.63 10.4 0.0 2.7 1 1 1 2 2 2 0 RING-like domain Exonuc_VII_L PF02601.15 ETO31380.1 - 0.23 11.0 7.5 0.34 10.5 7.5 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Gp58 PF07902.11 ETO31380.1 - 0.48 8.7 7.5 0.79 7.9 7.5 1.3 1 0 0 1 1 1 0 gp58-like protein Laminin_II PF06009.12 ETO31380.1 - 1 9.4 9.6 2.2 8.3 9.6 1.6 1 0 0 1 1 1 0 Laminin Domain II DUF730 PF05325.11 ETO31380.1 - 8.9 6.4 10.3 20 5.2 0.9 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF730) Adaptin_N PF01602.20 ETO31381.1 - 1.5e-113 380.2 12.1 1.9e-113 379.8 12.1 1.0 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO31381.1 - 2.1e-07 31.1 0.7 0.00053 20.1 0.0 3.0 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO31381.1 - 0.018 15.3 1.0 7.2 7.2 0.0 3.5 3 0 0 3 3 3 0 HEAT repeat AP3D1 PF06375.11 ETO31382.1 - 0.27 11.5 7.3 0.42 10.8 7.3 1.4 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 SR-25 PF10500.9 ETO31382.1 - 2.3 7.8 15.0 3.4 7.2 15.0 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_S49_N PF08496.10 ETO31382.1 - 2.3 8.2 8.8 3.8 7.6 8.8 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Pro_racemase PF05544.11 ETO31383.1 - 2.7e-45 154.8 0.1 8.6e-15 54.6 0.0 3.9 2 1 1 3 3 3 3 Proline racemase TSC22 PF01166.18 ETO31383.1 - 0.0038 17.5 0.6 0.0068 16.7 0.6 1.4 1 0 0 1 1 1 1 TSC-22/dip/bun family Pox_RNA_pol_35 PF03396.15 ETO31383.1 - 0.1 11.8 0.2 0.2 10.9 0.0 1.5 2 0 0 2 2 2 0 Poxvirus DNA-directed RNA polymerase, 35 kD subunit MIOX PF05153.15 ETO31384.1 - 1.8e-29 103.1 2.5 2e-29 102.9 2.5 1.1 1 0 0 1 1 1 1 Myo-inositol oxygenase Crr6 PF08847.11 ETO31384.1 - 0.1 12.2 0.0 0.13 12.0 0.0 1.2 1 0 0 1 1 1 0 Chlororespiratory reduction 6 SR-25 PF10500.9 ETO31384.1 - 1.2 8.7 8.7 1.4 8.5 8.7 1.1 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein VWA PF00092.28 ETO31385.1 - 0.00016 22.0 0.5 0.52 10.5 0.1 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain Kazal_2 PF07648.15 ETO31385.1 - 0.0011 19.0 8.1 0.0011 19.0 8.1 2.7 4 0 0 4 4 4 1 Kazal-type serine protease inhibitor domain Kazal_1 PF00050.21 ETO31385.1 - 0.0014 18.6 6.7 0.0014 18.6 6.7 3.3 4 0 0 4 4 4 1 Kazal-type serine protease inhibitor domain Rad60-SLD PF11976.8 ETO31386.1 - 0.1 12.4 0.0 0.38 10.6 0.0 2.0 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like DUF4162 PF13732.6 ETO31387.1 - 0.0073 17.0 1.0 0.0073 17.0 1.0 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4162) RasGEF_N PF00618.20 ETO31387.1 - 0.035 14.3 0.3 0.076 13.3 0.3 1.7 1 1 0 1 1 1 0 RasGEF N-terminal motif Herpes_UL87 PF03043.14 ETO31387.1 - 0.051 12.1 0.4 0.07 11.6 0.4 1.2 1 0 0 1 1 1 0 Herpesvirus UL87 family UPF0231 PF06062.11 ETO31387.1 - 0.053 13.8 3.5 0.12 12.6 3.3 1.8 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0231) RabGAP-TBC PF00566.18 ETO31388.1 - 1.3e-10 41.3 0.2 1.3e-10 41.3 0.2 2.6 4 0 0 4 4 4 1 Rab-GTPase-TBC domain DUF2833 PF11090.8 ETO31388.1 - 0.16 12.4 0.7 0.36 11.2 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2833) AF-4 PF05110.13 ETO31389.1 - 0.0036 15.5 13.5 0.0039 15.4 13.5 1.2 1 0 0 1 1 1 1 AF-4 proto-oncoprotein Presenilin PF01080.17 ETO31389.1 - 0.59 8.8 3.2 0.59 8.8 3.2 1.2 1 0 0 1 1 1 0 Presenilin Macoilin PF09726.9 ETO31389.1 - 4.5 5.7 16.1 5 5.6 16.1 1.1 1 0 0 1 1 1 0 Macoilin family Ion_trans PF00520.31 ETO31390.1 - 6.2e-09 35.5 2.2 1.1e-08 34.7 2.2 1.4 1 1 0 1 1 1 1 Ion transport protein Ion_trans PF00520.31 ETO31391.1 - 3.5e-21 75.5 3.6 4.2e-21 75.3 3.6 1.1 1 0 0 1 1 1 1 Ion transport protein SAM_2 PF07647.17 ETO31392.1 - 0.0061 16.7 0.0 0.0081 16.2 0.0 1.2 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO31392.1 - 0.13 12.7 0.0 0.19 12.2 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) WD40 PF00400.32 ETO31393.1 - 5e-11 43.0 11.7 1.1e-05 26.0 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31393.1 - 4.8e-07 30.0 1.0 0.0003 21.0 0.1 3.6 1 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO31393.1 - 8.1e-06 25.8 1.1 0.0025 17.7 0.1 2.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A CTX_RstB PF07459.11 ETO31393.1 - 0.099 12.9 0.0 0.21 11.9 0.0 1.5 1 0 0 1 1 1 0 CTX phage RstB protein DUF5436 PF17504.2 ETO31394.1 - 0.013 15.8 1.7 0.033 14.5 1.7 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5436) zf-UBR PF02207.20 ETO31395.1 - 3e-11 43.3 11.5 3e-11 43.3 11.5 4.0 3 2 0 3 3 3 1 Putative zinc finger in N-recognin (UBR box) ETRAMP PF09716.10 ETO31395.1 - 4.1 7.5 6.8 44 4.2 0.1 3.3 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Actin PF00022.19 ETO31396.1 - 6.1e-113 377.5 0.0 2.3e-112 375.6 0.0 1.7 1 1 0 1 1 1 1 Actin Peptidase_C12 PF01088.21 ETO31397.1 - 3.7e-52 177.1 0.0 6.2e-52 176.4 0.0 1.3 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase, family 1 zf-U1 PF06220.12 ETO31399.1 - 0.038 13.8 0.6 0.1 12.4 0.4 1.9 2 0 0 2 2 2 0 U1 zinc finger PMSR PF01625.21 ETO31399.1 - 0.31 11.2 1.9 0.37 11.0 0.3 1.9 2 0 0 2 2 2 0 Peptide methionine sulfoxide reductase Tubulin_C PF03953.17 ETO31400.1 - 1.1e-15 57.9 0.0 1.6e-15 57.4 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO31401.1 - 4.9e-70 235.7 0.0 6.6e-70 235.3 0.0 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_3 PF14881.6 ETO31401.1 - 0.0017 18.1 0.0 0.0022 17.7 0.0 1.3 1 0 0 1 1 1 1 Tubulin domain zf-C2H2 PF00096.26 ETO31402.1 - 4.4e-09 36.3 14.1 0.034 14.6 1.3 5.4 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO31402.1 - 5.8e-09 36.0 24.7 3.6e-08 33.5 2.0 4.2 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_6 PF13912.6 ETO31402.1 - 0.0023 17.9 14.5 0.087 12.9 0.2 3.7 3 0 0 3 3 3 3 C2H2-type zinc finger zf-BED PF02892.15 ETO31402.1 - 0.0044 17.0 1.6 0.0044 17.0 1.6 5.6 4 1 2 6 6 6 3 BED zinc finger PyrI_C PF02748.15 ETO31402.1 - 0.23 11.4 14.1 0.85 9.6 4.1 3.7 2 2 1 3 3 3 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-C2H2_4 PF13894.6 ETO31402.1 - 0.33 11.9 0.2 0.33 11.9 0.2 6.2 7 0 0 7 7 7 0 C2H2-type zinc finger zf-C2HE PF16278.5 ETO31402.1 - 2.4 8.7 10.3 19 5.8 0.2 3.8 2 1 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger HypA PF01155.19 ETO31402.1 - 9.8 6.2 11.6 20 5.2 0.5 3.3 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA SF3A2 PF16835.5 ETO31403.1 - 3.8e-33 113.7 0.1 4.9e-33 113.4 0.1 1.1 1 0 0 1 1 1 1 Pre-mRNA-splicing factor SF3a complex subunit 2 (Prp11) CactinC_cactus PF09732.9 ETO31403.1 - 0.0059 16.5 0.8 0.0085 16.0 0.8 1.4 1 1 0 1 1 1 1 Cactus-binding C-terminus of cactin protein COX6A PF02046.15 ETO31404.1 - 0.0098 16.4 5.5 0.019 15.4 5.5 1.6 1 0 0 1 1 1 1 Cytochrome c oxidase subunit VIa Peptidase_S68 PF10461.9 ETO31404.1 - 0.063 13.5 0.5 0.21 11.8 0.5 1.9 1 0 0 1 1 1 0 Peptidase S68 Spt20 PF12090.8 ETO31404.1 - 0.24 11.0 20.5 0.13 11.9 18.2 1.7 2 0 0 2 2 2 0 Spt20 family Presenilin PF01080.17 ETO31404.1 - 0.29 9.9 6.0 0.38 9.5 6.0 1.3 1 0 0 1 1 1 0 Presenilin EOS1 PF12326.8 ETO31404.1 - 0.32 10.9 3.0 0.57 10.1 3.0 1.4 1 0 0 1 1 1 0 N-glycosylation protein Neur_chan_memb PF02932.16 ETO31404.1 - 0.38 10.8 6.2 0.45 10.5 5.4 1.4 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region BRF1 PF07741.13 ETO31404.1 - 3.2 8.2 12.2 12 6.3 11.3 2.1 2 0 0 2 2 2 0 Brf1-like TBP-binding domain Androgen_recep PF02166.16 ETO31404.1 - 5.1 5.8 11.8 7.4 5.3 11.8 1.3 1 0 0 1 1 1 0 Androgen receptor ALMT PF11744.8 ETO31404.1 - 6.3 5.5 18.4 0.39 9.5 0.4 2.2 1 1 1 2 2 2 0 Aluminium activated malate transporter DEAD PF00270.29 ETO31405.1 - 3.9e-17 62.6 0.0 7.1e-09 35.7 0.0 3.0 2 1 0 3 3 3 2 DEAD/DEAH box helicase Methyltransf_31 PF13847.6 ETO31405.1 - 0.021 14.7 0.1 0.034 14.0 0.1 1.4 1 0 0 1 1 1 0 Methyltransferase domain Spc24 PF08286.11 ETO31405.1 - 0.11 12.8 1.2 0.22 11.8 1.2 1.5 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 APG6_N PF17675.1 ETO31405.1 - 0.16 12.5 5.7 0.28 11.7 5.7 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Herpes_UL6 PF01763.16 ETO31405.1 - 0.16 10.4 1.3 0.22 10.0 1.3 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like V-ATPase_C PF03223.15 ETO31405.1 - 0.27 10.6 3.0 6.5 6.0 1.3 2.5 2 1 1 3 3 3 0 V-ATPase subunit C Atg14 PF10186.9 ETO31405.1 - 0.78 8.8 4.9 1.2 8.2 4.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 NOT2_3_5 PF04153.18 ETO31407.1 - 2.2e-19 69.8 9.0 2.3e-19 69.8 7.7 1.7 1 1 0 1 1 1 1 NOT2 / NOT3 / NOT5 family THAP PF05485.12 ETO31407.1 - 0.27 12.2 3.8 3.3 8.7 1.8 2.5 2 0 0 2 2 2 0 THAP domain Pkinase PF00069.25 ETO31408.1 - 1.9e-17 63.5 0.0 1.9e-17 63.5 0.0 2.3 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31408.1 - 2.3e-05 23.8 0.0 2.3e-05 23.8 0.0 2.2 2 1 0 2 2 2 1 Protein tyrosine kinase CLN3 PF02487.17 ETO31408.1 - 0.0013 17.9 7.7 0.0013 17.9 7.7 1.7 1 1 1 2 2 2 1 CLN3 protein Lin-8 PF03353.15 ETO31408.1 - 0.0099 15.5 12.6 0.015 14.9 12.6 1.2 1 0 0 1 1 1 1 Ras-mediated vulval-induction antagonist Spt20 PF12090.8 ETO31408.1 - 0.012 15.2 26.9 0.052 13.1 26.9 1.9 1 1 0 1 1 1 0 Spt20 family DUF2961 PF11175.8 ETO31408.1 - 0.025 14.2 4.3 0.047 13.3 4.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2961) PAT1 PF09770.9 ETO31408.1 - 0.044 12.1 21.4 0.059 11.6 21.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 SLC12 PF03522.15 ETO31408.1 - 0.083 11.9 11.7 0.11 11.5 11.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SprA-related PF12118.8 ETO31408.1 - 0.21 10.7 17.6 0.39 9.8 17.6 1.4 1 0 0 1 1 1 0 SprA-related family Suf PF05843.14 ETO31408.1 - 0.64 9.9 15.2 0.97 9.4 15.2 1.3 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Presenilin PF01080.17 ETO31408.1 - 1.3 7.8 10.2 1.7 7.3 10.2 1.1 1 0 0 1 1 1 0 Presenilin Pex14_N PF04695.13 ETO31408.1 - 2.5 8.7 15.7 5.3 7.7 15.7 1.6 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region TFIIA PF03153.13 ETO31408.1 - 2.8 7.9 27.4 3.8 7.4 27.4 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Neur_chan_memb PF02932.16 ETO31408.1 - 3.6 7.6 8.4 5.5 7.0 8.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region dsDNA_bind PF01984.20 ETO31408.1 - 3.9 7.8 20.1 0.25 11.7 14.6 1.8 2 0 0 2 2 2 0 Double-stranded DNA-binding domain DUF853 PF05872.12 ETO31408.1 - 6.6 5.2 10.5 9.6 4.7 10.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) FliP PF00813.20 ETO31408.1 - 8.3 6.2 12.4 0.44 10.4 5.8 1.9 1 1 1 2 2 2 0 FliP family Med3 PF11593.8 ETO31408.1 - 8.4 5.5 25.6 12 4.9 25.6 1.1 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal Thiol_cytolys_C PF17440.2 ETO31410.1 - 0.009 16.2 0.2 0.32 11.2 0.1 2.2 2 0 0 2 2 2 2 Thiol-activated cytolysin beta sandwich domain Med3 PF11593.8 ETO31411.1 - 0.0017 17.6 2.5 0.003 16.8 2.5 1.3 1 0 0 1 1 1 1 Mediator complex subunit 3 fungal SPT6_acidic PF14632.6 ETO31411.1 - 5.1 7.8 11.9 29 5.3 11.9 2.1 1 1 0 1 1 1 0 Acidic N-terminal SPT6 DHHC PF01529.20 ETO31412.1 - 0.29 11.2 7.2 0.49 10.5 7.2 1.3 1 0 0 1 1 1 0 DHHC palmitoyltransferase IBR PF01485.21 ETO31413.1 - 8.9e-10 38.7 7.3 8.9e-10 38.7 7.3 2.1 2 0 0 2 2 2 1 IBR domain, a half RING-finger domain Rad60-SLD PF11976.8 ETO31413.1 - 0.049 13.5 0.2 0.12 12.2 0.2 1.6 1 0 0 1 1 1 0 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETO31413.1 - 0.051 13.3 0.1 0.16 11.7 0.1 1.8 2 0 0 2 2 2 0 Ubiquitin family HAND PF09110.11 ETO31414.1 - 3.3 8.5 14.7 7.6 7.3 0.4 2.3 2 0 0 2 2 2 0 HAND tRNA-synt_2d PF01409.20 ETO31415.1 - 2e-88 296.0 0.0 2.2e-88 295.9 0.0 1.0 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) tRNA_synthFbeta PF17759.1 ETO31415.1 - 1.7e-08 34.2 0.0 0.004 16.6 0.0 2.1 2 0 0 2 2 2 2 Phenylalanyl tRNA synthetase beta chain CLM domain tRNA-synt_2 PF00152.20 ETO31415.1 - 4.6e-05 22.6 0.1 0.0026 16.9 0.0 2.5 3 0 0 3 3 3 1 tRNA synthetases class II (D, K and N) tRNA-synt_2b PF00587.25 ETO31415.1 - 0.0013 18.8 0.0 0.0027 17.7 0.0 1.6 2 0 0 2 2 2 1 tRNA synthetase class II core domain (G, H, P, S and T) PheRS_DBD1 PF18552.1 ETO31416.1 - 3.1e-08 33.2 1.1 5.8e-08 32.4 0.3 1.9 2 0 0 2 2 2 1 PheRS DNA binding domain 1 TrmB PF01978.19 ETO31416.1 - 0.0018 18.1 0.0 0.0041 17.0 0.0 1.6 1 1 0 1 1 1 1 Sugar-specific transcriptional regulator TrmB FeoC PF09012.10 ETO31416.1 - 0.0034 17.4 0.0 0.0078 16.3 0.0 1.6 1 0 0 1 1 1 1 FeoC like transcriptional regulator Fe_dep_repress PF01325.19 ETO31416.1 - 0.0043 17.2 0.0 0.0095 16.1 0.0 1.6 1 0 0 1 1 1 1 Iron dependent repressor, N-terminal DNA binding domain HTH_24 PF13412.6 ETO31416.1 - 0.0054 16.3 0.0 0.0092 15.5 0.0 1.4 1 0 0 1 1 1 1 Winged helix-turn-helix DNA-binding RQC PF09382.10 ETO31416.1 - 0.006 16.4 0.0 0.016 15.0 0.0 1.7 1 0 0 1 1 1 1 RQC domain PadR PF03551.14 ETO31416.1 - 0.016 15.2 0.0 0.044 13.7 0.0 1.8 1 1 0 1 1 1 0 Transcriptional regulator PadR-like family RPA_C PF08784.11 ETO31416.1 - 0.022 15.4 0.2 0.022 15.4 0.2 1.9 2 0 0 2 2 2 0 Replication protein A C terminal DDRGK PF09756.9 ETO31416.1 - 0.025 14.2 9.8 0.059 12.9 9.8 1.7 1 1 0 1 1 1 0 DDRGK domain B-block_TFIIIC PF04182.12 ETO31416.1 - 0.026 14.7 0.9 0.076 13.2 0.9 1.8 1 1 0 1 1 1 0 B-block binding subunit of TFIIIC DUF4349 PF14257.6 ETO31416.1 - 0.039 13.4 1.0 0.45 9.9 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) GntR PF00392.21 ETO31416.1 - 0.09 12.4 0.0 0.16 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial regulatory proteins, gntR family PheRS_DBD3 PF18553.1 ETO31416.1 - 0.1 12.9 1.1 0.33 11.3 0.0 2.3 2 0 0 2 2 2 0 PheRS DNA binding domain 3 TMEM119 PF15724.5 ETO31416.1 - 1.6 8.8 5.9 5.6 6.9 5.9 2.0 1 1 0 1 1 1 0 TMEM119 family DUF5318 PF17249.2 ETO31418.1 - 0.02 14.6 0.6 1.9 8.3 0.1 2.6 2 0 0 2 2 2 0 Family of unknown function (DUF5318) zf-Di19 PF05605.12 ETO31418.1 - 0.059 13.7 1.6 0.14 12.4 0.2 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF1178 PF06676.11 ETO31418.1 - 0.24 11.8 0.2 0.24 11.8 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1178) ODV-E18 PF10717.9 ETO31418.1 - 3.7 7.5 4.7 5 7.1 3.6 1.7 2 0 0 2 2 2 0 Occlusion-derived virus envelope protein ODV-E18 ECSCR PF15820.5 ETO31418.1 - 9.5 6.1 7.2 9.9 6.1 3.8 2.5 2 0 0 2 2 2 0 Endothelial cell-specific chemotaxis regulator zf-RanBP PF00641.18 ETO31419.1 - 0.0096 15.2 5.4 0.0096 15.2 5.4 2.5 3 0 0 3 3 3 1 Zn-finger in Ran binding protein and others Cyclin PF08613.11 ETO31419.1 - 1 9.7 4.4 15 6.0 4.4 2.6 1 1 0 1 1 1 0 Cyclin Annexin PF00191.20 ETO31421.1 - 7.6e-26 90.0 13.4 1.3e-06 28.3 0.1 5.5 5 0 0 5 5 5 5 Annexin COG6 PF06419.11 ETO31422.1 - 3.2e-38 131.4 0.0 4e-38 131.1 0.0 1.0 1 0 0 1 1 1 1 Conserved oligomeric complex COG6 RRN3 PF05327.11 ETO31422.1 - 0.0021 16.7 0.4 0.0028 16.3 0.4 1.1 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 Secretin_N_2 PF07655.13 ETO31422.1 - 0.02 15.4 6.7 0.041 14.4 6.7 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Pox_Ag35 PF03286.14 ETO31422.1 - 0.033 14.0 0.3 0.045 13.5 0.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Menin PF05053.13 ETO31422.1 - 0.4 9.0 3.1 0.52 8.6 3.1 1.1 1 0 0 1 1 1 0 Menin DUF4637 PF15470.6 ETO31422.1 - 3.8 7.2 5.6 3.5 7.3 2.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Armet PF10208.9 ETO31423.1 - 0.0041 17.1 0.1 0.028 14.3 0.0 2.0 2 0 0 2 2 2 1 Degradation arginine-rich protein for mis-folding PHZA_PHZB PF03284.13 ETO31423.1 - 0.07 12.8 0.1 0.13 11.9 0.1 1.4 1 0 0 1 1 1 0 Phenazine biosynthesis protein A/B Lectin_leg-like PF03388.13 ETO31424.1 - 0.0051 16.2 0.5 0.0051 16.2 0.5 1.8 2 0 0 2 2 2 1 Legume-like lectin family Corona_NS3b PF03053.14 ETO31424.1 - 0.065 13.0 0.1 0.1 12.4 0.1 1.3 1 0 0 1 1 1 0 ORF3b coronavirus protein Rpr2 PF04032.16 ETO31425.1 - 0.00075 19.7 0.1 0.00075 19.7 0.1 2.2 2 1 0 2 2 2 1 RNAse P Rpr2/Rpp21/SNM1 subunit domain HisKA PF00512.25 ETO31425.1 - 0.054 13.5 0.0 3.8 7.6 0.0 2.4 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain ArfGap PF01412.18 ETO31425.1 - 0.31 11.1 3.3 0.31 11.1 0.9 2.2 2 1 0 2 2 2 0 Putative GTPase activating protein for Arf Copine PF07002.16 ETO31426.1 - 3.6e-36 124.7 0.1 5.1e-36 124.2 0.1 1.2 1 0 0 1 1 1 1 Copine C2 PF00168.30 ETO31426.1 - 8.7e-26 90.2 0.5 8.7e-12 45.3 0.0 2.5 2 0 0 2 2 2 2 C2 domain WW PF00397.26 ETO31427.1 - 1.6e-12 47.3 3.0 1.6e-12 47.3 3.0 2.6 3 0 0 3 3 3 1 WW domain Copine PF07002.16 ETO31427.1 - 4.8e-12 45.8 0.0 1e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Copine VCX_VCY PF15231.6 ETO31427.1 - 0.04 14.6 3.8 0.04 14.6 3.8 3.5 2 2 1 3 3 3 0 Variable charge X/Y family EIF4E-T PF10477.9 ETO31427.1 - 0.2 10.4 36.4 0.24 10.2 36.4 1.1 1 0 0 1 1 1 0 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E CttA_N PF18244.1 ETO31428.1 - 0.15 12.5 0.5 0.31 11.5 0.3 1.8 1 1 0 1 1 1 0 Cellulose-binding protein CttA N-terminal domain SDA1 PF05285.12 ETO31429.1 - 0.004 16.7 16.6 0.0044 16.5 16.6 1.1 1 0 0 1 1 1 1 SDA1 CLN3 PF02487.17 ETO31429.1 - 0.055 12.5 2.4 0.066 12.2 2.4 1.2 1 0 0 1 1 1 0 CLN3 protein eIF3_subunit PF08597.10 ETO31429.1 - 0.056 13.3 19.1 0.075 12.9 19.1 1.3 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Nop14 PF04147.12 ETO31429.1 - 0.064 11.5 19.4 0.076 11.2 19.4 1.1 1 0 0 1 1 1 0 Nop14-like family RNA_polI_A34 PF08208.11 ETO31429.1 - 0.13 12.3 16.6 0.19 11.8 16.6 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 NESP55 PF06390.12 ETO31429.1 - 0.23 11.0 10.1 0.33 10.5 10.1 1.3 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Trypan_PARP PF05887.11 ETO31429.1 - 0.32 11.0 14.7 0.6 10.1 14.7 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) ALMT PF11744.8 ETO31429.1 - 0.43 9.4 7.7 0.55 9.0 7.7 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.17 ETO31429.1 - 0.47 10.6 4.5 0.55 10.3 4.5 1.2 1 0 0 1 1 1 0 DDHD domain RP-C_C PF11800.8 ETO31429.1 - 0.54 10.3 4.9 0.62 10.1 4.9 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Neur_chan_memb PF02932.16 ETO31429.1 - 1 9.4 5.2 1.2 9.1 5.2 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO31429.1 - 1 8.5 4.9 1.1 8.4 4.9 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO31429.1 - 2.2 6.9 12.0 2.6 6.7 12.0 1.1 1 0 0 1 1 1 0 Presenilin RRN3 PF05327.11 ETO31429.1 - 2.3 6.7 12.1 2.7 6.5 12.1 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Paf1 PF03985.13 ETO31429.1 - 2.3 7.1 22.2 3.2 6.6 22.2 1.2 1 0 0 1 1 1 0 Paf1 PPL5 PF18168.1 ETO31429.1 - 2.4 7.4 8.0 2.9 7.1 8.0 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF4820 PF16091.5 ETO31429.1 - 4.9 6.4 9.9 8.6 5.7 9.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) NPR3 PF03666.13 ETO31429.1 - 6.7 5.4 11.4 8.4 5.1 11.4 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Coilin_N PF15862.5 ETO31429.1 - 8.3 6.2 15.7 15 5.4 14.4 2.1 2 0 0 2 2 2 0 Coilin N-terminus PTPRCAP PF15713.5 ETO31429.1 - 9.9 6.4 25.2 16 5.8 25.2 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated N1221 PF07923.13 ETO31430.1 - 0.047 12.9 0.1 0.052 12.7 0.1 1.2 1 0 0 1 1 1 0 N1221-like protein Ribosomal_L36e PF01158.18 ETO31431.1 - 1.8e-16 60.1 9.1 4.9e-14 52.3 7.9 2.4 1 1 0 1 1 1 1 Ribosomal protein L36e 4HB_MCP_1 PF12729.7 ETO31431.1 - 0.0055 16.3 0.5 0.0085 15.7 0.3 1.4 1 1 0 1 1 1 1 Four helix bundle sensory module for signal transduction SRP_TPR_like PF17004.5 ETO31431.1 - 0.031 14.3 2.3 0.06 13.4 2.3 1.6 1 1 0 1 1 1 0 Putative TPR-like repeat DUF4606 PF15379.6 ETO31431.1 - 0.065 13.5 5.0 0.11 12.8 5.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) Pkinase_Tyr PF07714.17 ETO31434.1 - 2.8e-50 171.0 0.0 3.9e-50 170.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO31434.1 - 1.6e-32 113.0 0.0 2.9e-32 112.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_fungal PF17667.1 ETO31434.1 - 0.00025 20.0 0.1 0.0009 18.1 0.0 1.7 2 0 0 2 2 2 1 Fungal protein kinase Kdo PF06293.14 ETO31434.1 - 0.068 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family WWE PF02825.20 ETO31435.1 - 2.2e-05 25.0 2.9 6e-05 23.6 0.3 2.5 2 0 0 2 2 2 1 WWE domain Ion_trans PF00520.31 ETO31435.1 - 0.00011 21.5 0.0 0.00082 18.7 0.0 2.1 2 0 0 2 2 2 1 Ion transport protein ATP-grasp_5 PF13549.6 ETO31435.1 - 0.18 11.3 0.2 0.32 10.4 0.0 1.5 2 0 0 2 2 2 0 ATP-grasp domain Thioredoxin_8 PF13905.6 ETO31435.1 - 0.82 10.0 10.6 0.7 10.3 1.2 3.1 3 1 0 3 3 3 0 Thioredoxin-like FeoB_Cyto PF17910.1 ETO31435.1 - 0.93 10.1 8.2 1 10.0 1.6 2.6 2 1 0 2 2 2 0 FeoB cytosolic helical domain ACR_tran PF00873.19 ETO31435.1 - 0.98 7.0 2.1 13 3.3 0.6 2.0 2 0 0 2 2 2 0 AcrB/AcrD/AcrF family PDR_assoc PF08370.11 ETO31435.1 - 1.2 8.9 3.4 8.2 6.3 1.0 2.5 2 0 0 2 2 2 0 Plant PDR ABC transporter associated DUF3347 PF11827.8 ETO31435.1 - 2.3 8.4 10.6 0.15 12.2 0.4 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3347) Stevor PF17410.2 ETO31436.1 - 0.061 12.9 1.2 0.22 11.1 0.2 1.9 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame Helitron_like_N PF14214.6 ETO31436.1 - 0.14 12.4 0.5 0.36 11.0 0.1 1.8 2 1 0 2 2 2 0 Helitron helicase-like domain at N-terminus HA2 PF04408.23 ETO31437.1 - 2.5e-21 76.0 0.0 2.5e-21 76.0 0.0 3.2 2 1 0 2 2 1 1 Helicase associated domain (HA2) OB_NTP_bind PF07717.16 ETO31437.1 - 1.4e-13 51.0 0.0 3.6e-13 49.7 0.0 1.7 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold Helicase_C PF00271.31 ETO31437.1 - 4.1e-08 33.5 0.1 2.1e-07 31.3 0.0 2.3 2 0 0 2 2 2 1 Helicase conserved C-terminal domain AAA_22 PF13401.6 ETO31437.1 - 9.3e-05 22.7 0.0 0.00025 21.3 0.0 1.7 1 0 0 1 1 1 1 AAA domain S1 PF00575.23 ETO31437.1 - 0.00051 20.3 2.5 0.0018 18.6 2.5 2.0 1 1 0 1 1 1 1 S1 RNA binding domain DEAD PF00270.29 ETO31437.1 - 0.00092 19.0 0.1 0.0026 17.5 0.1 1.7 1 1 0 1 1 1 1 DEAD/DEAH box helicase T2SSE PF00437.20 ETO31437.1 - 0.0014 17.8 0.0 0.0036 16.4 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein AAA_19 PF13245.6 ETO31437.1 - 0.0078 16.6 0.0 0.02 15.2 0.0 1.7 1 0 0 1 1 1 1 AAA domain AAA_30 PF13604.6 ETO31437.1 - 0.023 14.4 0.0 0.046 13.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO31437.1 - 0.052 13.0 0.1 0.12 11.8 0.1 1.5 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 ETO31437.1 - 0.2 12.2 2.2 2.2 8.8 0.4 3.3 2 1 0 2 2 2 0 ABC transporter VIT1 PF01988.19 ETO31438.1 - 0.067 13.1 0.1 19 5.1 1.8 2.6 2 0 0 2 2 2 0 VIT family NB PF04159.13 ETO31438.1 - 0.14 12.2 1.2 0.46 10.5 1.2 1.8 1 0 0 1 1 1 0 NB glycoprotein CDC45 PF02724.14 ETO31438.1 - 0.64 8.3 11.1 0.92 7.7 11.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Spt5_N PF11942.8 ETO31438.1 - 1.7 9.7 11.7 3.8 8.6 11.7 1.5 1 0 0 1 1 1 0 Spt5 transcription elongation factor, acidic N-terminal GCIP PF13324.6 ETO31438.1 - 2 8.0 5.7 3.1 7.3 5.7 1.2 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting RRN3 PF05327.11 ETO31438.1 - 4.1 5.8 5.8 6.7 5.1 5.8 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Abhydrolase_6 PF12697.7 ETO31439.1 - 2.2e-07 31.7 0.1 4e-07 30.9 0.1 1.6 1 1 0 1 1 1 1 Alpha/beta hydrolase family Abhydrolase_1 PF00561.20 ETO31439.1 - 3.3e-07 30.2 0.8 7.7e-07 29.0 0.8 1.9 1 1 0 1 1 1 1 alpha/beta hydrolase fold Hydrolase_4 PF12146.8 ETO31439.1 - 0.0047 16.2 0.0 0.009 15.3 0.0 1.5 1 0 0 1 1 1 1 Serine aminopeptidase, S33 PH PF00169.29 ETO31440.1 - 2.2e-10 41.0 0.2 2.2e-10 41.0 0.2 4.0 3 1 0 3 3 3 1 PH domain Mcp5_PH PF12814.7 ETO31440.1 - 0.071 13.2 0.4 0.071 13.2 0.4 2.6 2 0 0 2 2 2 0 Meiotic cell cortex C-terminal pleckstrin homology PH_8 PF15409.6 ETO31440.1 - 0.67 10.3 5.1 0.3 11.4 0.2 3.0 2 1 0 2 2 2 0 Pleckstrin homology domain DUF4094 PF13334.6 ETO31440.1 - 2.9 8.4 7.4 12 6.4 2.0 3.1 2 1 0 3 3 3 0 Domain of unknown function (DUF4094) S36_mt PF10937.8 ETO31440.1 - 6.7 8.3 6.2 62 5.2 0.1 3.3 2 1 1 3 3 3 0 Ribosomal protein S36, mitochondrial PHR PF08005.12 ETO31441.1 - 0.45 11.2 4.4 0.98 10.1 4.4 1.7 1 1 0 1 1 1 0 PHR domain Zap1_zf2 PF18217.1 ETO31441.1 - 0.69 10.0 6.2 0.32 11.0 3.5 1.9 2 0 0 2 2 2 0 Zap1 zinc finger 2 KASH_CCD PF14662.6 ETO31442.1 - 4.1e-05 23.5 27.4 0.03 14.2 4.2 3.0 1 1 2 3 3 3 3 Coiled-coil region of CCDC155 or KASH SlyX PF04102.12 ETO31442.1 - 0.011 16.3 0.1 0.011 16.3 0.1 3.5 3 1 1 4 4 4 0 SlyX Shugoshin_N PF07558.11 ETO31442.1 - 0.012 15.4 3.6 11 6.0 0.2 4.1 2 1 1 3 3 3 0 Shugoshin N-terminal coiled-coil region TMF_DNA_bd PF12329.8 ETO31442.1 - 0.013 15.5 11.2 0.013 15.5 11.2 3.6 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF724 PF05266.14 ETO31442.1 - 0.018 14.9 22.4 0.064 13.1 6.3 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF724) Telomere_reg-2 PF10193.9 ETO31442.1 - 0.038 14.4 0.4 0.1 13.1 0.2 1.8 1 1 0 1 1 1 0 Telomere length regulation protein Lebercilin PF15619.6 ETO31442.1 - 0.088 12.5 30.5 0.024 14.3 19.4 2.2 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease SHE3 PF17078.5 ETO31442.1 - 0.18 11.5 21.1 6.7 6.4 18.7 2.8 1 1 1 2 2 2 0 SWI5-dependent HO expression protein 3 DUF2205 PF10224.9 ETO31442.1 - 0.37 10.8 14.1 1.5 8.9 1.3 3.7 1 1 3 4 4 4 0 Short coiled-coil protein DUF1672 PF07901.11 ETO31442.1 - 0.46 9.8 5.3 0.81 9.0 5.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1672) MAD PF05557.13 ETO31442.1 - 0.73 8.1 28.0 1.5 7.1 28.0 1.8 1 1 0 1 1 1 0 Mitotic checkpoint protein HALZ PF02183.18 ETO31442.1 - 0.8 10.0 20.1 2.8 8.3 0.3 4.8 4 1 0 4 4 4 0 Homeobox associated leucine zipper ERM PF00769.19 ETO31442.1 - 0.92 9.3 33.8 0.024 14.5 7.7 2.6 1 1 0 2 2 2 0 Ezrin/radixin/moesin family Ly49 PF08391.10 ETO31442.1 - 1 9.8 13.0 0.69 10.3 1.3 2.6 1 1 2 3 3 3 0 Ly49-like protein, N-terminal region Mod_r PF07200.13 ETO31442.1 - 2.2 8.4 25.6 0.19 11.8 12.0 2.2 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein HIP1_clath_bdg PF16515.5 ETO31442.1 - 2.5 8.8 21.0 6.9 7.3 0.6 3.1 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Fez1 PF06818.15 ETO31442.1 - 3.3 8.1 24.8 0.14 12.6 3.1 2.6 1 1 1 2 2 2 0 Fez1 Herpes_UL25 PF01499.16 ETO31442.1 - 3.4 6.1 12.5 0.056 12.0 4.9 1.6 1 1 1 2 2 2 0 Herpesvirus UL25 family DUF1664 PF07889.12 ETO31442.1 - 4.1 7.5 11.1 7.3 6.7 1.1 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF1664) AAA_13 PF13166.6 ETO31442.1 - 4.4 5.8 21.9 5.3 5.6 21.9 1.0 1 0 0 1 1 1 0 AAA domain Cep57_CLD_2 PF14197.6 ETO31442.1 - 5.2 7.2 28.6 2.5 8.3 3.8 5.0 1 1 2 4 4 4 0 Centrosome localisation domain of PPC89 TPR_MLP1_2 PF07926.12 ETO31442.1 - 5.7 7.0 33.2 2.2 8.3 20.5 2.9 1 1 2 3 3 3 0 TPR/MLP1/MLP2-like protein Yuri_gagarin PF15934.5 ETO31442.1 - 7.7 6.3 18.6 10 5.9 18.6 1.0 1 0 0 1 1 1 0 Yuri gagarin FAM76 PF16046.5 ETO31442.1 - 8.1 5.7 18.9 1.3 8.4 12.8 2.0 1 1 1 2 2 2 0 FAM76 protein LRR_6 PF13516.6 ETO31443.1 - 8.2e-09 34.8 0.3 0.0026 17.7 0.0 4.2 4 0 0 4 4 4 3 Leucine Rich repeat LRR_1 PF00560.33 ETO31443.1 - 0.096 13.3 0.2 28 5.8 0.1 3.4 3 0 0 3 3 3 0 Leucine Rich Repeat Caskin-Pro-rich PF16907.5 ETO31444.1 - 0.12 12.9 0.4 0.65 10.5 0.4 2.0 2 0 0 2 2 2 0 Proline rich region of Caskin proteins Phi-29_GP16_7 PF06720.11 ETO31445.1 - 0.073 12.9 0.4 0.23 11.3 0.4 1.7 2 0 0 2 2 2 0 Bacteriophage phi-29 early protein GP16.7 Kelch_5 PF13854.6 ETO31446.1 - 0.021 14.8 0.1 0.13 12.3 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO31447.1 - 5.8e-10 38.6 0.6 1.3e-07 31.1 0.8 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO31447.1 - 4.1e-07 30.1 1.0 0.00014 22.0 0.2 2.2 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO31447.1 - 2.2e-06 27.5 0.1 0.00023 21.1 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO31447.1 - 0.00048 20.4 0.0 0.0012 19.1 0.0 1.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO31447.1 - 0.00053 19.9 0.5 0.082 12.9 0.4 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO31447.1 - 0.0032 17.4 3.4 0.011 15.7 1.7 2.1 2 0 0 2 2 2 1 Kelch motif DUF2072 PF09845.9 ETO31447.1 - 0.043 14.1 3.1 0.062 13.6 3.1 1.2 1 0 0 1 1 1 0 Zn-ribbon containing protein PRKG1_interact PF15898.5 ETO31447.1 - 0.57 11.1 9.1 0.82 10.6 9.1 1.1 1 0 0 1 1 1 0 cGMP-dependent protein kinase interacting domain TFR_dimer PF04253.15 ETO31447.1 - 1.8 8.7 5.1 2.9 8.0 4.4 1.6 1 1 1 2 2 2 0 Transferrin receptor-like dimerisation domain Comm PF15957.5 ETO31448.1 - 0.033 14.5 0.1 0.04 14.3 0.1 1.2 1 0 0 1 1 1 0 Commissureless Drc1-Sld2 PF11719.8 ETO31448.1 - 0.1 12.1 4.3 0.13 11.8 4.3 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein PT PF04886.12 ETO31448.1 - 0.78 9.3 7.0 0.25 10.9 3.1 2.0 2 0 0 2 2 2 0 PT repeat Ivy PF08816.11 ETO31452.1 - 0.018 15.2 1.4 0.035 14.3 1.3 1.6 1 1 0 1 1 1 0 Inhibitor of vertebrate lysozyme (Ivy) CAF1 PF04857.20 ETO31452.1 - 0.041 13.1 0.2 0.062 12.5 0.2 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Ras PF00071.22 ETO31454.1 - 2.2e-24 85.9 0.7 3e-24 85.4 0.7 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO31454.1 - 2.4e-07 31.0 0.3 6e-07 29.7 0.3 1.7 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RTTN_N PF14726.6 ETO31454.1 - 0.12 13.1 0.1 0.2 12.4 0.1 1.4 1 0 0 1 1 1 0 Rotatin, an armadillo repeat protein, centriole functioning DUF4312 PF14189.6 ETO31455.1 - 0.024 14.6 4.4 0.088 12.8 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4312) PatG_D PF18047.1 ETO31456.1 - 0.42 11.1 5.8 0.12 12.8 1.3 2.5 2 1 0 2 2 2 0 PatG Domain COX14 PF14880.6 ETO31457.1 - 0.014 15.2 0.2 0.055 13.3 0.0 2.1 3 0 0 3 3 3 0 Cytochrome oxidase c assembly UAA PF08449.11 ETO31457.1 - 0.022 14.0 0.7 0.022 14.0 0.7 1.5 2 0 0 2 2 2 0 UAA transporter family EamA PF00892.20 ETO31457.1 - 0.027 14.6 6.2 0.027 14.6 6.2 1.9 2 0 0 2 2 2 0 EamA-like transporter family TPT PF03151.16 ETO31457.1 - 0.2 10.9 3.2 0.072 12.4 0.8 1.4 2 0 0 2 2 2 0 Triose-phosphate Transporter family UCH PF00443.29 ETO31458.1 - 4e-14 52.7 4.0 9.4e-14 51.5 0.1 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO31458.1 - 1e-06 28.6 0.2 1.9e-06 27.7 0.2 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Dpoe2NT PF12213.8 ETO31458.1 - 0.84 10.0 2.9 3.6 7.9 0.0 3.1 3 0 0 3 3 3 0 DNA polymerases epsilon N terminal EF-G-binding_N PF07299.11 ETO31458.1 - 2 9.0 5.6 7.4 7.2 0.1 3.4 4 0 0 4 4 4 0 Elongation factor G-binding protein, N-terminal UCH PF00443.29 ETO31459.1 - 3.3e-23 82.5 0.3 3.3e-23 82.5 0.3 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO31459.1 - 1e-15 58.2 4.2 1e-15 58.2 4.2 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF3367 PF11847.8 ETO31459.1 - 0.52 8.1 2.7 0.73 7.6 2.7 1.1 1 0 0 1 1 1 0 Alpha-(1->3)-arabinofuranosyltransferase NYAP_C PF15452.6 ETO31460.1 - 0.0049 16.8 0.2 0.0069 16.3 0.2 1.1 1 0 0 1 1 1 1 Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter Coat_F PF07875.12 ETO31461.1 - 0.035 14.4 0.0 0.09 13.0 0.0 1.7 1 0 0 1 1 1 0 Coat F domain LodA_N PF17990.1 ETO31461.1 - 0.11 12.4 0.0 0.16 11.8 0.0 1.3 1 0 0 1 1 1 0 L-Lysine epsilon oxidase N-terminal Microtub_bd PF16796.5 ETO31462.1 - 6.2e-23 81.4 1.4 6.2e-23 81.4 1.4 2.7 2 1 0 2 2 2 1 Microtubule binding Kinesin PF00225.23 ETO31462.1 - 3.7e-10 39.2 0.4 3.7e-10 39.2 0.4 2.2 2 1 1 3 3 3 1 Kinesin motor domain Nucleotid_trans PF03407.16 ETO31463.1 - 3.4e-13 50.1 0.1 4.9e-13 49.6 0.1 1.2 1 0 0 1 1 1 1 Nucleotide-diphospho-sugar transferase ENTH PF01417.20 ETO31466.1 - 1.4e-05 25.2 0.0 2.1e-05 24.6 0.0 1.3 1 0 0 1 1 1 1 ENTH domain zinc_ribbon_10 PF10058.9 ETO31467.1 - 0.098 12.4 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Rieske PF00355.26 ETO31468.1 - 7.4e-11 41.8 0.8 1.2e-10 41.1 0.8 1.4 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 ETO31468.1 - 0.0008 19.8 0.0 0.0036 17.8 0.0 2.1 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region DUF563 PF04577.14 ETO31469.1 - 7.3e-26 91.6 1.7 9.7e-26 91.2 0.4 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF563) DUF4683 PF15735.5 ETO31470.1 - 0.15 11.7 7.1 0.19 11.3 7.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4683) AAA PF00004.29 ETO31471.1 - 0.021 15.2 0.2 0.062 13.7 0.0 2.0 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO31471.1 - 0.035 14.4 0.1 0.14 12.5 0.0 2.1 1 1 0 1 1 1 0 AAA domain AAA_5 PF07728.14 ETO31471.1 - 0.038 14.0 0.1 0.15 12.1 0.1 2.0 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) ClpB_D2-small PF10431.9 ETO31471.1 - 2.8 8.1 6.3 7.7 6.6 0.1 3.5 4 0 0 4 4 4 0 C-terminal, D2-small domain, of ClpB protein DUF4746 PF15928.5 ETO31472.1 - 0.013 14.9 5.2 0.016 14.7 5.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF3435 PF11917.8 ETO31472.1 - 0.076 11.9 3.6 0.084 11.8 3.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) PI3K_P85_iSH2 PF16454.5 ETO31473.1 - 0.058 13.0 8.6 0.12 12.0 8.6 1.5 1 1 0 1 1 1 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain DASH_Spc19 PF08287.11 ETO31473.1 - 0.066 13.1 10.0 0.093 12.6 10.0 1.1 1 0 0 1 1 1 0 Spc19 CRR7 PF12095.8 ETO31473.1 - 0.096 13.1 1.7 0.33 11.4 1.5 2.0 1 1 1 2 2 2 0 Protein CHLORORESPIRATORY REDUCTION 7 CENP-K PF11802.8 ETO31473.1 - 0.099 12.2 8.4 0.1 12.1 8.4 1.1 1 0 0 1 1 1 0 Centromere-associated protein K CENP-O PF09496.10 ETO31473.1 - 0.12 12.3 1.8 0.14 12.2 1.8 1.1 1 0 0 1 1 1 0 Cenp-O kinetochore centromere component DUF2205 PF10224.9 ETO31473.1 - 0.39 10.8 7.1 0.24 11.4 5.3 1.7 1 1 1 2 2 2 0 Short coiled-coil protein YabA PF06156.13 ETO31473.1 - 0.56 10.9 5.9 0.78 10.4 5.9 1.3 1 0 0 1 1 1 0 Initiation control protein YabA Rho_Binding PF08912.11 ETO31473.1 - 0.98 10.3 14.4 0.14 13.0 8.7 2.1 1 1 1 2 2 2 0 Rho Binding BST2 PF16716.5 ETO31473.1 - 8.6 7.0 11.8 4.5 7.9 5.7 2.0 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 WD40 PF00400.32 ETO31476.1 - 5.1e-62 204.3 23.9 2.7e-11 43.8 0.3 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31476.1 - 5.9e-20 71.4 7.4 2.2e-05 24.7 0.0 6.6 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31476.1 - 4.4e-11 42.7 2.5 0.002 17.5 0.2 3.9 2 1 2 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO31476.1 - 1.2e-09 37.6 0.6 0.094 11.7 0.0 5.1 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO31476.1 - 1.2e-08 34.1 6.2 0.46 9.1 0.1 5.7 2 1 4 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO31476.1 - 0.0051 16.7 3.7 0.54 10.3 0.0 3.9 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO31476.1 - 0.015 15.4 0.2 1.2 9.2 0.0 3.5 3 1 1 4 4 4 0 Family of unknown function (DUF5570) Pneumo_NS1 PF03438.13 ETO31476.1 - 0.05 13.7 0.0 0.27 11.4 0.0 2.3 2 0 0 2 2 2 0 Pneumovirus NS1 protein DUF2415 PF10313.9 ETO31476.1 - 0.08 12.9 0.0 7.3 6.6 0.0 2.9 2 0 0 2 2 2 0 Uncharacterised protein domain (DUF2415) RVT_thumb PF06817.14 ETO31476.1 - 0.091 12.6 0.3 0.64 9.9 0.1 2.2 2 0 0 2 2 2 0 Reverse transcriptase thumb domain Prot_ATP_ID_OB PF16450.5 ETO31476.1 - 0.14 12.2 0.4 9.4 6.3 0.0 3.5 4 1 0 4 4 4 0 Proteasomal ATPase OB C-terminal domain NHL PF01436.21 ETO31476.1 - 0.16 12.1 2.1 26 5.1 0.0 3.5 4 0 0 4 4 4 0 NHL repeat SPRY PF00622.28 ETO31477.1 - 2.4e-05 24.4 0.0 3.6e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain DnaJ PF00226.31 ETO31478.1 - 1.1e-10 41.5 1.1 2.4e-10 40.4 1.1 1.6 1 0 0 1 1 1 1 DnaJ domain CorA PF01544.18 ETO31478.1 - 0.56 9.5 5.7 1.2 8.4 0.9 2.1 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF3439 PF11921.8 ETO31478.1 - 2.5 8.1 7.2 0.77 9.7 4.3 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) SelR PF01641.18 ETO31481.1 - 8.2e-31 106.6 0.5 1e-30 106.3 0.5 1.2 1 0 0 1 1 1 1 SelR domain FA_hydroxylase PF04116.13 ETO31482.1 - 5.6e-12 46.2 15.5 5.6e-12 46.2 15.5 1.7 2 0 0 2 2 2 1 Fatty acid hydroxylase superfamily Thioredoxin PF00085.20 ETO31483.1 - 2.6e-07 30.5 0.0 5.2e-07 29.6 0.0 1.5 1 0 0 1 1 1 1 Thioredoxin Orf78 PF06024.12 ETO31485.1 - 0.087 13.1 2.7 0.17 12.2 2.7 1.5 1 0 0 1 1 1 0 Orf78 (ac78) 2-Hacid_dh PF00389.30 ETO31486.1 - 0.0011 18.7 0.0 0.0038 16.9 0.0 1.8 2 0 0 2 2 2 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain Tau95_N PF17682.1 ETO31487.1 - 0.71 10.1 7.4 0.3 11.3 1.2 2.3 2 0 0 2 2 2 0 Tau95 Triple barrel domain PDEase_I PF00233.19 ETO31489.1 - 9.2e-15 55.0 0.0 1.1e-14 54.8 0.0 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase FAM176 PF14851.6 ETO31490.1 - 0.0092 15.7 0.1 0.0092 15.7 0.1 2.4 2 1 0 2 2 2 1 FAM176 family Sporozoite_P67 PF05642.11 ETO31490.1 - 0.033 12.3 4.2 0.065 11.3 4.2 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Zip PF02535.22 ETO31490.1 - 0.066 12.4 0.0 0.066 12.4 0.0 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter AP-5_subunit_s1 PF15001.6 ETO31490.1 - 0.11 12.5 2.0 1.4 8.9 0.2 2.2 2 0 0 2 2 2 0 AP-5 complex subunit sigma-1 DUF4834 PF16118.5 ETO31490.1 - 0.13 13.2 3.2 3.5 8.6 0.0 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) Vfa1 PF08432.10 ETO31490.1 - 0.14 12.5 16.7 1.2 9.4 2.3 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Dsh_C PF12316.8 ETO31490.1 - 0.2 12.0 6.1 1.1 9.6 0.3 2.1 2 0 0 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal Ctr PF04145.15 ETO31490.1 - 0.28 11.8 1.1 1.3 9.7 0.0 2.2 2 1 0 2 2 2 0 Ctr copper transporter family CDC45 PF02724.14 ETO31490.1 - 0.48 8.6 13.2 0.088 11.1 5.6 2.0 2 0 0 2 2 2 0 CDC45-like protein RasGEF_N PF00618.20 ETO31490.1 - 1.1 9.6 9.4 0.46 10.7 2.9 2.4 1 1 1 2 2 2 0 RasGEF N-terminal motif Peptidase_S49_N PF08496.10 ETO31490.1 - 7.5 6.6 10.0 3.4 7.7 1.5 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal EI24 PF07264.11 ETO31491.1 - 1.5 9.0 9.0 1.4 9.1 9.0 1.1 1 0 0 1 1 1 0 Etoposide-induced protein 2.4 (EI24) Pex24p PF06398.11 ETO31491.1 - 5.7 5.8 7.5 5.5 5.9 7.5 1.2 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin DUF3458_C PF17432.2 ETO31492.1 - 1e-70 238.6 0.0 1.1e-68 232.0 0.0 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats Peptidase_M1 PF01433.20 ETO31492.1 - 2.8e-47 161.1 1.2 1.2e-27 96.9 0.0 2.5 2 0 0 2 2 2 2 Peptidase family M1 domain DUF3458 PF11940.8 ETO31492.1 - 5.1e-20 71.7 0.2 4e-18 65.6 0.0 3.3 2 1 0 2 2 2 1 Domain of unknown function (DUF3458) Ig-like fold zf-CCCH PF00642.24 ETO31493.1 - 2.7e-05 23.9 5.5 4.2e-05 23.4 5.5 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) Osmo_CC PF08946.10 ETO31493.1 - 0.036 14.3 1.6 0.08 13.2 1.2 1.7 2 0 0 2 2 2 0 Osmosensory transporter coiled coil PI3K_P85_iSH2 PF16454.5 ETO31493.1 - 0.041 13.5 2.2 2.4 7.7 0.4 2.2 2 0 0 2 2 2 0 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain zf_CCCH_4 PF18345.1 ETO31493.1 - 0.044 13.9 7.9 0.072 13.2 7.9 1.4 1 0 0 1 1 1 0 Zinc finger domain BAR_3 PF16746.5 ETO31493.1 - 0.17 11.5 1.3 0.4 10.4 0.2 1.9 2 0 0 2 2 2 0 BAR domain of APPL family WD40 PF00400.32 ETO31494.1 - 2.8e-22 78.6 16.3 1.5e-07 31.9 0.0 8.2 8 0 0 8 8 8 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31494.1 - 1.1e-13 51.3 0.2 0.0023 18.2 0.0 5.2 2 2 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31494.1 - 3.3e-06 26.3 0.2 1.3 7.9 0.0 4.2 4 1 1 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO31494.1 - 0.0039 17.1 0.0 7.5 6.6 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO31494.1 - 0.005 16.2 0.7 0.04 13.2 0.0 2.6 3 0 0 3 3 3 1 WD40-like domain Nbas_N PF15492.6 ETO31494.1 - 0.023 14.0 0.7 12 5.2 0.1 3.2 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Utp12 PF04003.12 ETO31495.1 - 7e-18 64.9 0.4 1.1e-17 64.3 0.4 1.3 1 0 0 1 1 1 1 Dip2/Utp12 Family DFRP_C PF16543.5 ETO31496.1 - 2.4e-08 34.4 8.1 2.4e-08 34.4 8.1 5.5 1 1 4 5 5 5 1 DRG Family Regulatory Proteins, Tma46 Alpha_Helical PF18489.1 ETO31496.1 - 0.4 10.9 8.0 0.85 9.8 2.6 3.0 2 2 0 2 2 2 0 Alpha helical domain Hydrolase_like PF13242.6 ETO31497.1 - 0.0058 16.7 0.0 0.01 15.9 0.0 1.3 1 0 0 1 1 1 1 HAD-hyrolase-like zf-TRAF PF02176.18 ETO31498.1 - 0.00061 20.4 4.6 0.00061 20.4 4.6 3.0 2 0 0 2 2 2 1 TRAF-type zinc finger HSP70 PF00012.20 ETO31499.1 - 6.1e-27 94.1 0.0 8.1e-27 93.7 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein CspB_prodomain PF18425.1 ETO31499.1 - 0.013 15.5 0.0 0.031 14.3 0.0 1.6 1 0 0 1 1 1 0 Csp protease B prodomain Transpeptidase PF00905.22 ETO31499.1 - 0.025 13.8 0.1 0.037 13.2 0.1 1.2 1 0 0 1 1 1 0 Penicillin binding protein transpeptidase domain DNA_pol_A PF00476.20 ETO31499.1 - 0.069 12.2 0.0 0.097 11.7 0.0 1.2 1 0 0 1 1 1 0 DNA polymerase family A CAP_GLY PF01302.25 ETO31501.1 - 2.2e-69 229.4 15.5 3.1e-18 65.6 0.4 4.4 4 0 0 4 4 4 4 CAP-Gly domain MitMem_reg PF13012.6 ETO31501.1 - 0.24 11.8 1.0 0.41 11.1 1.0 1.3 1 0 0 1 1 1 0 Maintenance of mitochondrial structure and function zf-GRF PF06839.12 ETO31501.1 - 0.37 10.9 5.0 5.8 7.1 0.3 2.6 2 0 0 2 2 2 0 GRF zinc finger WD40 PF00400.32 ETO31502.1 - 1.9e-66 218.4 18.9 1.6e-11 44.5 0.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31502.1 - 1.8e-19 69.8 5.4 0.017 15.4 0.0 6.5 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31502.1 - 5.2e-14 51.9 0.8 0.0077 15.2 0.0 6.1 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO31502.1 - 7.4e-11 41.9 1.4 0.00082 18.8 0.0 3.4 3 0 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO31502.1 - 3.8e-07 29.1 11.3 0.17 10.5 0.0 5.8 2 1 4 6 6 6 5 Nucleoporin Nup120/160 Asp_decarbox PF02261.16 ETO31502.1 - 0.0052 16.7 0.1 0.96 9.4 0.0 2.9 3 1 0 3 3 3 1 Aspartate decarboxylase SBD PF17882.1 ETO31502.1 - 0.048 13.5 1.7 5.2 6.9 0.2 3.6 1 1 2 3 3 3 0 OAA-family lectin sugar binding domain PD40 PF07676.12 ETO31502.1 - 0.11 12.4 2.4 7.7 6.6 0.0 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Complex1_LYR PF05347.15 ETO31503.1 - 1.8e-06 27.9 0.4 1.8e-06 27.9 0.4 1.9 2 0 0 2 2 2 1 Complex 1 protein (LYR family) Clathrin_H_link PF13838.6 ETO31503.1 - 0.0037 17.1 0.0 0.0071 16.2 0.0 1.4 1 0 0 1 1 1 1 Clathrin-H-link Complex1_LYR_2 PF13233.6 ETO31503.1 - 0.26 12.0 4.8 1.8 9.4 4.8 2.1 1 1 0 1 1 1 0 Complex1_LYR-like Kelch_4 PF13418.6 ETO31504.1 - 0.00018 21.4 2.2 0.011 15.7 0.1 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO31504.1 - 0.001 19.0 7.7 0.36 10.9 0.8 4.2 3 1 1 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO31504.1 - 0.0012 19.0 5.2 1.1 9.6 0.0 4.6 4 1 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO31504.1 - 0.026 14.1 3.5 0.97 9.1 0.4 3.9 4 0 0 4 4 4 0 Kelch motif TPR_12 PF13424.6 ETO31506.1 - 5.7e-87 286.1 7.3 4.3e-19 68.6 0.0 7.1 5 1 2 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31506.1 - 2.4e-62 204.4 54.9 8.2e-09 34.9 0.6 10.7 10 1 0 10 10 10 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO31506.1 - 5.4e-61 200.9 4.8 4.2e-07 29.6 0.0 10.9 11 0 0 11 11 10 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31506.1 - 7.3e-57 185.3 11.8 1.8e-06 27.5 0.0 10.9 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31506.1 - 4.9e-52 169.8 56.7 8.4e-07 28.7 1.2 12.0 13 0 0 13 13 13 10 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31506.1 - 9e-47 153.5 39.6 1.4e-06 27.9 0.1 10.7 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31506.1 - 1.3e-23 82.3 39.4 0.0026 17.4 1.0 12.5 11 2 2 13 13 13 7 TPR repeat SNAP PF14938.6 ETO31506.1 - 3.9e-18 65.9 17.3 1.1e-07 31.6 3.1 3.8 1 1 2 3 3 3 3 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO31506.1 - 9.3e-16 57.0 17.1 0.2 12.1 0.1 10.9 9 2 1 10 10 10 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31506.1 - 4.4e-15 55.1 0.0 8.4 7.5 0.0 10.0 9 2 2 11 11 9 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO31506.1 - 5.8e-14 51.7 11.5 0.88 10.4 0.1 9.5 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO31506.1 - 3.1e-13 49.4 25.1 0.0041 17.1 0.3 7.5 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO31506.1 - 5.4e-13 49.0 0.0 0.00039 19.9 0.0 3.8 1 1 3 4 4 4 3 MalT-like TPR region TPR_16 PF13432.6 ETO31506.1 - 9.8e-13 48.5 0.0 0.027 15.1 0.0 7.0 5 2 1 6 6 6 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO31506.1 - 3e-09 36.9 20.0 0.0087 15.8 0.6 5.7 1 1 2 3 3 3 3 Uncharacterized protein conserved in bacteria (DUF2225) SHNi-TPR PF10516.9 ETO31506.1 - 9.7e-08 31.3 4.4 0.22 11.0 0.0 6.9 9 0 0 9 9 9 2 SHNi-TPR DUF5113 PF17140.4 ETO31506.1 - 1.4e-06 28.3 27.1 2 8.2 0.5 9.1 7 2 2 9 9 9 2 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO31506.1 - 0.00037 20.9 5.1 0.75 10.4 0.0 5.4 3 1 4 7 7 6 1 Tetratricopeptide repeat Sel1 PF08238.12 ETO31506.1 - 0.0025 18.4 15.2 43 5.0 0.0 7.4 7 0 0 7 7 6 0 Sel1 repeat DUF4810 PF16068.5 ETO31506.1 - 0.0067 17.0 9.8 23 5.6 0.0 6.9 6 1 2 8 8 7 0 Domain of unknown function (DUF4810) ANAPC3 PF12895.7 ETO31506.1 - 0.013 15.7 18.9 0.023 14.9 2.3 6.0 3 2 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO31506.1 - 0.014 15.5 38.8 2.2 8.4 0.2 9.3 8 2 2 10 10 9 0 MIT (microtubule interacting and transport) domain RPN7 PF10602.9 ETO31506.1 - 0.026 14.2 21.9 0.86 9.3 1.8 5.8 2 1 2 5 5 5 0 26S proteasome subunit RPN7 PPR PF01535.20 ETO31506.1 - 0.04 14.2 23.4 2.8 8.4 0.5 8.4 10 0 0 10 10 8 0 PPR repeat OEP PF02321.18 ETO31506.1 - 0.089 12.6 0.1 1.1 9.0 0.2 2.8 2 1 0 2 2 2 0 Outer membrane efflux protein DUF627 PF04781.12 ETO31506.1 - 0.27 11.3 17.0 0.74 9.9 0.1 6.0 5 2 2 7 7 5 0 Protein of unknown function (DUF627) TPR_12 PF13424.6 ETO31507.1 - 5e-58 193.3 8.7 1.4e-18 67.0 0.1 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO31507.1 - 4.6e-42 140.8 0.2 1.8e-06 27.6 0.0 7.5 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31507.1 - 2.8e-39 130.3 8.6 1.5e-06 27.8 0.0 7.4 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31507.1 - 4.8e-32 108.5 51.9 3.4e-08 33.0 0.8 8.2 8 1 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31507.1 - 5.2e-28 94.9 54.5 4.3e-05 23.4 0.8 8.5 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31507.1 - 1.3e-26 90.5 37.2 0.00035 20.5 0.3 8.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31507.1 - 1.6e-10 40.5 31.0 0.022 14.5 0.7 9.1 9 1 1 10 10 10 4 TPR repeat TPR_6 PF13174.6 ETO31507.1 - 3e-09 36.9 13.2 4.7 8.1 0.0 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31507.1 - 1.6e-07 31.6 0.3 16 6.6 0.0 6.5 6 0 0 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31507.1 - 4.4e-07 30.4 0.5 11 6.8 0.0 5.7 5 2 0 5 5 5 0 Tetratricopeptide repeat MIT PF04212.18 ETO31507.1 - 2.1e-06 27.7 28.1 0.089 12.9 0.2 6.7 5 2 2 7 7 6 3 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETO31507.1 - 4.2e-05 23.1 0.0 0.05 13.0 0.0 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_17 PF13431.6 ETO31507.1 - 4.2e-05 23.6 22.1 0.038 14.4 0.1 8.5 5 2 2 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO31507.1 - 0.00034 20.0 0.7 6.4 6.3 0.1 4.7 4 0 0 4 4 4 1 SHNi-TPR TPR_19 PF14559.6 ETO31507.1 - 0.0015 19.0 4.5 3.3 8.3 0.0 5.3 4 2 2 6 6 6 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO31507.1 - 0.0015 18.3 22.6 0.13 12.0 2.8 5.4 1 1 3 4 4 4 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_9 PF13371.6 ETO31507.1 - 0.0049 17.0 0.0 7 6.9 0.0 3.4 4 0 0 4 4 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO31507.1 - 0.015 15.3 21.3 2.4 8.3 0.2 6.6 6 1 0 6 6 6 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO31507.1 - 0.02 14.7 26.8 0.89 9.3 0.1 6.9 6 2 2 8 8 8 0 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO31507.1 - 0.05 13.8 15.9 2.1 8.6 6.9 4.4 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 Rab3-GTPase_cat PF13890.6 ETO31507.1 - 0.077 12.6 1.3 0.14 11.8 1.3 1.3 1 0 0 1 1 1 0 Rab3 GTPase-activating protein catalytic subunit DUF1643 PF07799.12 ETO31507.1 - 0.27 11.4 5.8 1.1 9.5 2.9 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1643) DUF3856 PF12968.7 ETO31507.1 - 0.31 11.1 4.5 3.1 7.8 0.3 3.6 3 1 1 4 4 3 0 Domain of Unknown Function (DUF3856) DUF627 PF04781.12 ETO31507.1 - 0.58 10.2 6.4 4.3 7.4 0.1 4.2 3 2 0 3 3 3 0 Protein of unknown function (DUF627) Sel1 PF08238.12 ETO31507.1 - 0.59 10.9 12.6 30 5.5 0.1 5.8 6 0 0 6 6 5 0 Sel1 repeat HTH_Bact PF18768.1 ETO31507.1 - 0.62 9.7 10.6 29 4.3 0.1 5.7 6 0 0 6 6 6 0 Helix-turn-helix bacterial domain ERG4_ERG24 PF01222.17 ETO31508.1 - 2.2e-87 293.6 19.8 2.6e-87 293.4 19.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ETO31508.1 - 4.7 6.6 15.8 33 3.9 15.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) LRR_8 PF13855.6 ETO31509.1 - 5.2e-05 22.9 14.1 0.00092 18.9 4.2 3.5 2 1 2 4 4 4 3 Leucine rich repeat LRR_4 PF12799.7 ETO31509.1 - 0.0025 18.2 13.9 0.22 12.0 0.4 3.5 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) DUF4283 PF14111.6 ETO31509.1 - 0.094 12.2 0.5 0.27 10.8 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4283) LRR_1 PF00560.33 ETO31509.1 - 0.26 12.0 14.6 19 6.3 0.5 6.0 5 1 1 6 6 6 0 Leucine Rich Repeat DUF1772 PF08592.11 ETO31510.1 - 8 6.8 8.8 3.1 8.1 3.1 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF1772) Bap31 PF05529.12 ETO31511.1 - 0.089 12.7 2.5 3.9 7.3 0.1 2.4 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region Topoisom_bac PF01131.20 ETO31512.1 - 1.3e-97 327.4 0.0 1.5e-97 327.3 0.0 1.0 1 0 0 1 1 1 1 DNA topoisomerase WD40 PF00400.32 ETO31513.1 - 2.5e-55 183.2 18.3 4.4e-09 36.8 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31513.1 - 2.1e-15 56.8 1.6 0.00054 20.2 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31513.1 - 1.6e-13 50.3 0.1 0.052 12.5 0.0 5.8 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO31513.1 - 4.4e-08 33.2 0.5 0.11 12.3 0.0 3.6 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A HARP PF07443.13 ETO31513.1 - 1e-05 25.1 0.0 4.1 7.1 0.0 4.7 4 0 0 4 4 4 1 HepA-related protein (HARP) Nup160 PF11715.8 ETO31513.1 - 9.7e-05 21.2 5.6 3.2 6.3 0.1 4.8 3 2 2 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO31513.1 - 0.00097 17.8 0.1 2.7 6.4 0.0 3.4 1 1 4 5 5 5 3 Cytochrome D1 heme domain VID27 PF08553.10 ETO31513.1 - 0.045 12.8 0.0 0.13 11.3 0.0 1.6 1 1 0 1 1 1 0 VID27 C-terminal WD40-like domain Str_synth PF03088.16 ETO31513.1 - 0.052 13.7 0.4 4 7.6 0.0 3.5 2 1 2 4 4 4 0 Strictosidine synthase Peptidase_C14 PF00656.22 ETO31514.1 - 1.2e-07 32.0 0.3 2e-07 31.3 0.3 1.3 1 0 0 1 1 1 1 Caspase domain zf-TRAF PF02176.18 ETO31514.1 - 0.0034 18.0 0.7 0.0034 18.0 0.7 2.4 2 1 0 2 2 2 1 TRAF-type zinc finger zf-C3HC4_2 PF13923.6 ETO31514.1 - 0.61 10.0 6.2 3.4 7.6 2.5 3.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) KRTAP PF11759.8 ETO31515.1 - 7 7.3 40.8 45 4.7 40.8 2.1 1 1 0 1 1 1 0 Keratin-associated matrix Lyase_8_N PF08124.11 ETO31516.1 - 0.0036 16.3 4.7 0.0045 16.0 4.2 1.3 1 1 0 1 1 1 1 Polysaccharide lyase family 8, N terminal alpha-helical domain BLOC1_2 PF10046.9 ETO31516.1 - 0.007 16.6 5.0 0.01 16.1 3.7 1.8 1 1 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Herpes_UL17 PF04559.12 ETO31516.1 - 0.057 12.2 0.0 0.11 11.3 0.0 1.5 1 1 0 1 1 1 0 Herpesvirus UL17 protein PPR_long PF17177.4 ETO31517.1 - 5.4e-06 25.9 0.5 1.2e-05 24.7 0.5 1.5 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_3 PF13812.6 ETO31517.1 - 1.9e-05 24.7 2.1 2.9e-05 24.1 0.0 2.5 3 0 0 3 3 3 1 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO31517.1 - 0.0024 18.0 8.1 0.037 14.2 0.2 5.1 5 1 1 6 6 6 2 PPR repeat family PPR PF01535.20 ETO31517.1 - 0.0071 16.5 5.5 42 4.7 0.0 5.4 5 0 0 5 5 5 0 PPR repeat MIEAP PF16026.5 ETO31517.1 - 0.045 14.0 1.9 9.5 6.4 0.0 2.7 2 0 0 2 2 2 0 Mitochondria-eating protein DUF3585 PF12130.8 ETO31517.1 - 3.7 7.7 7.5 0.16 12.1 0.4 2.3 3 0 0 3 3 3 0 Bivalent Mical/EHBP Rab binding domain Mito_carr PF00153.27 ETO31518.1 - 3e-49 164.9 1.5 7.2e-16 57.9 0.0 3.2 3 0 0 3 3 3 3 Mitochondrial carrier protein DUF3770 PF12603.8 ETO31518.1 - 0.016 14.7 0.3 0.024 14.2 0.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3770) Corazonin PF17308.2 ETO31518.1 - 0.019 15.3 7.9 0.038 14.4 7.9 1.4 1 0 0 1 1 1 0 Pro-corazonin TauE PF01925.19 ETO31518.1 - 0.14 11.8 3.2 0.18 11.4 0.0 2.4 2 1 0 2 2 2 0 Sulfite exporter TauE/SafE zf-RVT PF13966.6 ETO31519.1 - 0.033 14.9 0.5 0.081 13.6 0.5 1.8 1 1 0 1 1 1 0 zinc-binding in reverse transcriptase Mitofilin PF09731.9 ETO31520.1 - 0.016 14.1 17.1 0.023 13.6 17.1 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Calpain_inhib PF00748.19 ETO31520.1 - 0.093 13.2 3.8 0.19 12.2 3.8 1.5 1 0 0 1 1 1 0 Calpain inhibitor GIDA_assoc PF13932.6 ETO31520.1 - 0.25 11.5 12.6 0.42 10.8 12.6 1.3 1 0 0 1 1 1 0 GidA associated domain WXG100 PF06013.12 ETO31520.1 - 0.41 10.9 5.7 5.7 7.3 2.7 2.4 1 1 1 2 2 2 0 Proteins of 100 residues with WXG V_ATPase_I PF01496.19 ETO31520.1 - 0.8 7.6 8.2 1.1 7.0 8.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Tsi6 PF18660.1 ETO31520.1 - 0.95 9.6 5.6 0.18 11.9 1.3 2.0 3 0 0 3 3 3 0 Tsi6 Exonuc_VII_L PF02601.15 ETO31520.1 - 1.2 8.6 9.5 1.7 8.1 9.5 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mit_KHE1 PF10173.9 ETO31520.1 - 3.7 7.6 10.8 1.2e+02 2.6 11.7 2.5 2 1 0 2 2 2 0 Mitochondrial K+-H+ exchange-related MEIOC PF15189.6 ETO31520.1 - 4.1 7.0 12.6 0.3 10.7 1.1 2.5 2 1 1 3 3 3 0 Meiosis-specific coiled-coil domain-containing protein MEIOC Fib_alpha PF08702.10 ETO31520.1 - 4.3 7.5 17.8 9.2 6.4 17.8 1.5 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family DUF4541 PF15074.6 ETO31520.1 - 4.3 8.0 5.8 22 5.8 2.1 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF4541) COG5 PF10392.9 ETO31520.1 - 4.9 7.3 10.9 0.37 11.0 2.9 2.7 2 1 1 3 3 3 0 Golgi transport complex subunit 5 UPF0449 PF15136.6 ETO31520.1 - 7.7 7.1 13.8 7.9 7.0 1.9 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 LMBR1 PF04791.16 ETO31520.1 - 7.7 5.3 9.1 11 4.8 9.1 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 ETO31522.1 - 2.7e-46 154.6 15.3 2.3e-07 31.4 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31522.1 - 1.4e-23 83.0 2.5 0.00083 19.6 0.0 6.1 1 1 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31522.1 - 2e-13 50.3 0.9 8.1e-07 28.7 0.0 3.5 1 1 2 3 3 3 2 WD40-like domain eIF2A PF08662.11 ETO31522.1 - 1e-09 38.6 1.6 6.1e-07 29.5 0.2 3.4 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO31522.1 - 2.2e-09 36.8 0.1 1.1 8.1 0.0 5.5 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO31522.1 - 1.8e-08 34.1 6.4 0.0021 17.9 0.0 5.7 6 0 0 6 6 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO31522.1 - 2.5e-07 29.7 0.4 0.25 10.0 0.1 4.6 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO31522.1 - 0.00011 20.8 0.2 0.025 13.1 0.0 2.5 1 1 2 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO31522.1 - 0.00017 21.7 0.8 4.4 7.4 0.0 4.3 2 2 1 4 4 4 2 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO31522.1 - 0.00027 20.1 1.7 0.05 12.6 0.3 2.3 1 1 1 2 2 2 2 Coatomer WD associated region PQQ_2 PF13360.6 ETO31522.1 - 0.00095 18.8 0.0 0.0039 16.8 0.0 1.9 1 1 0 1 1 1 1 PQQ-like domain Nucleoporin_N PF08801.11 ETO31522.1 - 0.001 17.9 6.7 0.62 8.7 0.3 4.1 1 1 2 3 3 3 2 Nup133 N terminal like DUF4988 PF16378.5 ETO31522.1 - 0.0013 18.4 0.3 4.3 7.0 0.0 3.4 2 1 0 3 3 3 2 Domain of unknown function DPPIV_N PF00930.21 ETO31522.1 - 0.0035 16.2 0.1 0.32 9.7 0.0 2.9 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Frtz PF11768.8 ETO31522.1 - 0.042 12.2 0.0 6.7 4.9 0.0 2.4 3 0 0 3 3 3 0 WD repeat-containing and planar cell polarity effector protein Fritz VID27 PF08553.10 ETO31522.1 - 0.05 12.7 0.2 1.4 7.9 0.1 2.4 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain IKI3 PF04762.12 ETO31522.1 - 0.056 11.4 0.0 0.45 8.4 0.0 2.1 1 1 1 3 3 3 0 IKI3 family Utp8 PF10395.9 ETO31522.1 - 0.13 10.8 0.4 2.1 6.7 0.0 2.3 1 1 1 2 2 2 0 Utp8 family DUF2963 PF11178.8 ETO31522.1 - 0.84 9.4 7.7 29 4.4 1.0 5.0 4 1 1 5 5 5 0 Protein of unknown function (DUF2963) WD40 PF00400.32 ETO31523.1 - 2.1e-44 148.6 22.8 3.9e-07 30.7 0.1 8.7 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31523.1 - 1.1e-11 44.9 0.0 0.032 14.5 0.1 5.4 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31523.1 - 6.2e-08 31.7 3.5 0.071 11.7 0.0 4.7 2 1 3 5 5 5 4 Nucleoporin Nup120/160 MFS_1 PF07690.16 ETO31524.1 - 3.2e-21 75.6 31.8 1.9e-11 43.5 11.6 2.5 2 0 0 2 2 2 2 Major Facilitator Superfamily DUF3943 PF13084.6 ETO31524.1 - 0.045 13.6 0.4 0.75 9.7 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3943) Blt1 PF12754.7 ETO31524.1 - 0.16 12.3 0.0 0.3 11.4 0.0 1.4 1 0 0 1 1 1 0 Blt1 N-terminal domain HCO3_cotransp PF00955.21 ETO31528.1 - 1 8.1 8.8 1.5 7.6 8.8 1.3 1 0 0 1 1 1 0 HCO3- transporter family Utp14 PF04615.13 ETO31528.1 - 5.4 5.5 24.7 6.4 5.2 24.7 1.1 1 0 0 1 1 1 0 Utp14 protein Trypan_PARP PF05887.11 ETO31529.1 - 4.8 7.2 8.6 9.9 6.2 8.6 1.5 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Hydrolase_3 PF08282.12 ETO31530.1 - 0.0025 17.6 8.2 0.0031 17.3 8.2 1.1 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase HDA2-3 PF11496.8 ETO31530.1 - 0.046 12.9 4.0 0.052 12.7 4.0 1.1 1 0 0 1 1 1 0 Class II histone deacetylase complex subunits 2 and 3 RasGEF_N PF00618.20 ETO31531.1 - 0.089 13.0 0.1 1.7 9.0 0.0 2.4 2 0 0 2 2 2 0 RasGEF N-terminal motif CobT PF06213.12 ETO31531.1 - 0.12 11.8 3.9 0.17 11.3 3.9 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CENP-B_dimeris PF09026.10 ETO31531.1 - 0.26 11.7 8.6 0.46 10.9 8.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain zf-RING_2 PF13639.6 ETO31533.1 - 6.6e-13 48.8 4.2 1.1e-12 48.1 4.2 1.4 1 0 0 1 1 1 1 Ring finger domain zf-RING_11 PF17123.5 ETO31533.1 - 4e-10 39.2 2.6 4e-10 39.2 2.6 1.8 2 0 0 2 2 1 1 RING-like zinc finger zf-C3HC4_2 PF13923.6 ETO31533.1 - 7.3e-10 38.5 4.3 1.3e-09 37.8 4.3 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO31533.1 - 4.6e-08 33.2 4.1 1.2e-07 31.9 4.1 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO31533.1 - 6.3e-08 32.4 2.4 1.1e-07 31.6 2.4 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO31533.1 - 4.2e-06 26.6 2.5 6.9e-06 25.9 2.5 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO31533.1 - 5.9e-05 23.0 5.3 0.00013 21.9 0.8 2.6 2 0 0 2 2 2 1 RING-type zinc-finger zf-ANAPC11 PF12861.7 ETO31533.1 - 7.3e-05 22.7 2.3 0.00012 22.0 2.3 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_3 PF13920.6 ETO31533.1 - 0.00033 20.4 1.1 0.00053 19.8 1.1 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) PHD PF00628.29 ETO31533.1 - 0.0029 17.5 2.8 0.0054 16.6 2.8 1.5 1 0 0 1 1 1 1 PHD-finger Zn_ribbon_17 PF17120.5 ETO31533.1 - 0.0079 15.8 2.8 0.013 15.1 2.8 1.3 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type BUD22 PF09073.10 ETO31533.1 - 0.039 13.3 6.6 0.05 13.0 6.6 1.1 1 0 0 1 1 1 0 BUD22 RINGv PF12906.7 ETO31533.1 - 0.044 13.9 2.1 0.1 12.7 2.1 1.7 1 1 0 1 1 1 0 RING-variant domain PAP1 PF08601.10 ETO31533.1 - 0.044 13.5 11.0 0.053 13.2 11.0 1.0 1 0 0 1 1 1 0 Transcription factor PAP1 zf-RING-like PF08746.11 ETO31533.1 - 0.059 13.7 1.8 0.1 12.9 1.8 1.4 1 0 0 1 1 1 0 RING-like domain Mem_trans PF03547.18 ETO31533.1 - 0.083 11.3 1.4 0.089 11.2 1.4 1.1 1 0 0 1 1 1 0 Membrane transport protein Prok-RING_4 PF14447.6 ETO31533.1 - 0.09 12.7 4.2 0.25 11.2 4.3 1.8 1 1 0 1 1 1 0 Prokaryotic RING finger family 4 Herpes_pp85 PF04637.12 ETO31533.1 - 0.13 10.7 8.1 0.18 10.2 8.1 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) zf-RING_4 PF14570.6 ETO31533.1 - 0.14 11.9 1.9 0.26 11.1 1.9 1.4 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain zf-C3HC4_4 PF15227.6 ETO31533.1 - 0.15 12.3 2.5 0.37 11.0 2.5 1.7 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING TerB_C PF15615.6 ETO31533.1 - 0.2 12.0 2.9 0.24 11.7 2.3 1.4 1 1 0 1 1 1 0 TerB-C domain Macoilin PF09726.9 ETO31533.1 - 0.37 9.3 10.4 0.43 9.1 10.4 1.0 1 0 0 1 1 1 0 Macoilin family FANCL_C PF11793.8 ETO31533.1 - 0.73 10.1 4.9 5.1 7.4 4.9 2.2 1 1 0 1 1 1 0 FANCL C-terminal domain ORC3_N PF07034.11 ETO31535.1 - 3.1e-14 52.8 24.2 0.0013 17.9 3.2 4.2 3 1 1 4 4 4 4 Origin recognition complex (ORC) subunit 3 N-terminus DUF4446 PF14584.6 ETO31535.1 - 0.11 12.5 4.9 0.48 10.4 1.9 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) MSC PF09402.10 ETO31535.1 - 1.1 8.7 4.7 0.58 9.5 1.5 2.1 2 0 0 2 2 2 0 Man1-Src1p-C-terminal domain Peptidase_S49_N PF08496.10 ETO31535.1 - 5.1 7.1 8.9 2.5 8.2 1.1 2.7 2 1 0 2 2 2 0 Peptidase family S49 N-terminal EphA2_TM PF14575.6 ETO31535.1 - 8.8 7.3 6.4 2.8 8.9 0.1 3.0 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain DUF5331 PF17265.2 ETO31536.1 - 0.039 13.7 0.3 0.039 13.7 0.3 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5331) RRT14 PF17075.5 ETO31536.1 - 3.5 7.7 25.6 5.7 7.0 25.7 1.3 1 1 0 1 1 1 0 Regular of rDNA transcription protein 14 YmgB PF10798.8 ETO31537.1 - 1.7 8.5 11.9 5.4 6.9 2.6 3.7 3 0 0 3 3 3 0 Biofilm development protein YmgB/AriR TMF_TATA_bd PF12325.8 ETO31537.1 - 1.7 8.9 23.5 0.28 11.4 14.1 3.1 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding DUF745 PF05335.13 ETO31537.1 - 7.7 6.2 11.2 5.4 6.7 0.3 2.8 2 1 1 3 3 3 0 Protein of unknown function (DUF745) CSRNP_N PF16019.5 ETO31538.1 - 9.7 6.0 9.8 3.3 7.6 5.9 2.0 1 1 1 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus NST1 PF13945.6 ETO31539.1 - 1.1 9.3 16.1 1.6 8.8 16.1 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Menin PF05053.13 ETO31539.1 - 1.3 7.3 8.6 1.6 7.0 8.6 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO31539.1 - 3.6 6.3 6.2 4.7 5.9 6.2 1.1 1 0 0 1 1 1 0 Presenilin Secretin_N_2 PF07655.13 ETO31539.1 - 3.6 8.2 23.3 1.1 9.8 13.6 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain zf-B_box PF00643.24 ETO31540.1 - 0.33 11.1 2.9 4.4 7.5 0.1 2.9 2 1 1 3 3 3 0 B-box zinc finger RasGEF PF00617.19 ETO31542.1 - 4.8e-30 105.1 0.3 6.7e-30 104.6 0.3 1.3 1 0 0 1 1 1 1 RasGEF domain Vps51 PF08700.11 ETO31542.1 - 0.23 11.5 1.2 0.54 10.4 0.1 2.2 2 1 0 2 2 2 0 Vps51/Vps67 Metallophos PF00149.28 ETO31543.1 - 1.8e-25 90.7 0.0 2.6e-25 90.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO31543.1 - 0.027 14.7 0.0 0.038 14.2 0.0 1.2 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain U-box PF04564.15 ETO31544.1 - 1.7e-12 47.3 0.1 7.8e-12 45.2 0.0 2.2 2 0 0 2 2 2 1 U-box domain zf-Nse PF11789.8 ETO31544.1 - 3.5e-05 23.5 0.0 8.2e-05 22.4 0.0 1.5 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit MMR_HSR1 PF01926.23 ETO31544.1 - 0.00011 22.3 0.0 0.0003 20.8 0.0 1.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase zf-RING_UBOX PF13445.6 ETO31544.1 - 0.00013 21.9 0.0 0.00036 20.5 0.0 1.8 1 0 0 1 1 1 1 RING-type zinc-finger ABC_tran PF00005.27 ETO31544.1 - 0.0034 17.9 0.0 0.013 16.0 0.0 2.0 1 0 0 1 1 1 1 ABC transporter zf-C3HC4_4 PF15227.6 ETO31544.1 - 0.0048 17.0 0.0 0.013 15.6 0.0 1.8 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING RsgA_GTPase PF03193.16 ETO31544.1 - 0.0077 16.2 0.0 0.017 15.0 0.0 1.5 1 0 0 1 1 1 1 RsgA GTPase AAA_14 PF13173.6 ETO31544.1 - 0.054 13.5 0.0 0.19 11.8 0.0 1.9 1 0 0 1 1 1 0 AAA domain YopD PF05844.12 ETO31544.1 - 0.055 12.5 2.3 0.073 12.1 1.3 1.6 2 0 0 2 2 2 0 YopD protein DUF4748 PF15932.5 ETO31544.1 - 0.28 11.0 1.0 1 9.2 1.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4748) DUF1932 PF09130.11 ETO31545.1 - 0.2 11.7 0.0 0.37 10.8 0.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1932) Myosin_head PF00063.21 ETO31546.1 - 9.1e-19 67.1 0.0 9.1e-19 67.1 0.0 1.9 2 0 0 2 2 2 1 Myosin head (motor domain) Myosin_head PF00063.21 ETO31547.1 - 8.5e-79 265.5 1.3 1e-78 265.2 1.3 1.0 1 0 0 1 1 1 1 Myosin head (motor domain) PH PF00169.29 ETO31550.1 - 4.4e-09 36.8 1.9 1.3e-06 28.9 0.0 3.2 3 0 0 3 3 3 1 PH domain PH_2 PF08458.10 ETO31550.1 - 8.6e-06 26.1 1.4 4.7e-05 23.7 0.1 2.9 3 0 0 3 3 3 1 Plant pleckstrin homology-like region PX PF00787.24 ETO31550.1 - 4.6e-05 23.4 0.1 4.6e-05 23.4 0.1 2.4 3 0 0 3 3 3 1 PX domain PH_8 PF15409.6 ETO31550.1 - 0.012 15.8 0.2 0.14 12.4 0.0 2.8 2 1 0 2 2 2 0 Pleckstrin homology domain MCC-bdg_PDZ PF10506.9 ETO31550.1 - 0.24 11.5 21.4 0.45 10.5 0.9 3.9 4 0 0 4 4 4 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF4407 PF14362.6 ETO31550.1 - 1.1 8.5 22.8 2.3 7.5 13.2 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) DUF4164 PF13747.6 ETO31550.1 - 2.3 8.6 17.2 0.25 11.6 9.3 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) HrpB7 PF09486.10 ETO31550.1 - 4 7.8 19.0 0.81 10.1 9.8 2.2 1 1 1 2 2 2 0 Bacterial type III secretion protein (HrpB7) Prominin PF05478.11 ETO31550.1 - 4.7 5.0 15.2 8.9 4.1 15.2 1.4 1 0 0 1 1 1 0 Prominin CwfJ_C_1 PF04677.15 ETO31551.1 - 9e-29 99.8 0.0 1.9e-28 98.8 0.0 1.5 1 0 0 1 1 1 1 Protein similar to CwfJ C-terminus 1 CwfJ_C_2 PF04676.14 ETO31551.1 - 3e-13 50.5 0.0 1.4e-12 48.3 0.0 2.2 2 0 0 2 2 2 1 Protein similar to CwfJ C-terminus 2 zf-CCHC_2 PF13696.6 ETO31551.1 - 1e-05 25.2 5.2 2.6e-05 23.9 5.2 1.7 1 0 0 1 1 1 1 Zinc knuckle zf-CCHC PF00098.23 ETO31551.1 - 4.3e-05 23.4 1.8 0.00013 21.8 1.8 1.9 1 0 0 1 1 1 1 Zinc knuckle MutS_IV PF05190.18 ETO31551.1 - 0.05 13.9 1.0 0.15 12.4 1.0 1.8 1 0 0 1 1 1 0 MutS family domain IV zf-CCHC_3 PF13917.6 ETO31551.1 - 0.064 13.2 0.2 0.15 12.0 0.2 1.6 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_4 PF14392.6 ETO31551.1 - 0.33 10.7 3.6 0.66 9.8 0.8 2.4 2 0 0 2 2 2 0 Zinc knuckle VWA_3 PF13768.6 ETO31552.1 - 0.028 14.4 0.0 0.13 12.2 0.0 2.2 2 0 0 2 2 2 0 von Willebrand factor type A domain AAA PF00004.29 ETO31553.1 - 1.7e-42 145.0 0.0 3.9e-42 143.8 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_lid_3 PF17862.1 ETO31553.1 - 3.2e-13 49.3 0.0 6.8e-13 48.2 0.0 1.6 1 0 0 1 1 1 1 AAA+ lid domain Prot_ATP_ID_OB PF16450.5 ETO31553.1 - 2e-09 37.2 0.1 4.9e-09 36.0 0.1 1.7 1 0 0 1 1 1 1 Proteasomal ATPase OB C-terminal domain AAA_5 PF07728.14 ETO31553.1 - 1e-06 28.8 0.1 3.2e-05 23.9 0.1 2.6 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO31553.1 - 2.2e-06 28.2 0.0 0.00086 19.7 0.0 2.9 2 1 0 3 3 3 1 AAA ATPase domain AAA_2 PF07724.14 ETO31553.1 - 2.3e-06 27.9 0.0 7.2e-06 26.2 0.0 1.9 2 0 0 2 2 1 1 AAA domain (Cdc48 subfamily) RuvB_N PF05496.12 ETO31553.1 - 4e-06 26.7 0.0 1e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain DUF815 PF05673.13 ETO31553.1 - 0.00038 19.7 0.0 0.00081 18.6 0.0 1.6 1 0 0 1 1 1 1 Protein of unknown function (DUF815) AAA_22 PF13401.6 ETO31553.1 - 0.00091 19.5 0.9 0.013 15.8 0.0 2.8 2 1 1 3 3 3 1 AAA domain IstB_IS21 PF01695.17 ETO31553.1 - 0.001 18.9 0.1 0.0082 15.9 0.0 2.3 2 0 0 2 2 2 1 IstB-like ATP binding protein AAA_18 PF13238.6 ETO31553.1 - 0.002 18.7 0.0 0.01 16.4 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETO31553.1 - 0.0029 17.1 0.0 0.0072 15.9 0.0 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA_3 PF07726.11 ETO31553.1 - 0.0032 17.3 0.1 0.0099 15.7 0.0 1.8 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ETO31553.1 - 0.0051 16.2 0.1 0.01 15.2 0.1 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO31553.1 - 0.0052 16.5 0.0 0.032 13.9 0.0 2.3 1 1 0 1 1 1 1 Sigma-54 interaction domain TsaE PF02367.17 ETO31553.1 - 0.0054 16.7 0.0 0.0096 15.9 0.0 1.4 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETO31553.1 - 0.0059 17.0 0.0 0.013 15.8 0.0 1.6 1 0 0 1 1 1 1 RNA helicase Parvo_NS1 PF01057.17 ETO31553.1 - 0.0062 15.7 0.0 0.013 14.6 0.0 1.4 1 0 0 1 1 1 1 Parvovirus non-structural protein NS1 TIP49 PF06068.13 ETO31553.1 - 0.0076 15.5 0.0 0.024 13.8 0.0 1.8 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_24 PF13479.6 ETO31553.1 - 0.008 15.9 0.0 0.022 14.5 0.0 1.7 1 1 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETO31553.1 - 0.03 14.5 0.0 0.067 13.4 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO31553.1 - 0.039 14.1 0.0 0.087 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain PhoH PF02562.16 ETO31553.1 - 0.04 13.4 0.0 0.085 12.3 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein eIF-1a PF01176.19 ETO31553.1 - 0.057 13.2 0.1 0.12 12.2 0.1 1.5 1 0 0 1 1 1 0 Translation initiation factor 1A / IF-1 AAA_14 PF13173.6 ETO31553.1 - 0.068 13.2 0.0 0.16 12.0 0.0 1.6 1 0 0 1 1 1 0 AAA domain PIF1 PF05970.14 ETO31553.1 - 0.093 11.9 0.0 0.15 11.2 0.0 1.3 1 0 0 1 1 1 0 PIF1-like helicase AAA_11 PF13086.6 ETO31553.1 - 0.094 12.5 0.2 0.28 10.9 0.0 1.9 2 0 0 2 2 2 0 AAA domain AAA_25 PF13481.6 ETO31553.1 - 0.099 12.2 0.0 0.27 10.8 0.0 1.6 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ETO31553.1 - 0.1 11.9 1.9 0.19 11.0 0.0 2.2 3 0 0 3 3 2 0 KaiC Prot_ATP_OB_N PF17758.1 ETO31553.1 - 0.18 11.5 0.1 0.45 10.2 0.0 1.7 2 0 0 2 2 1 0 Proteasomal ATPase OB N-terminal domain WD40 PF00400.32 ETO31555.1 - 4.2e-13 49.6 8.3 8.5e-07 29.6 1.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31555.1 - 0.099 13.0 0.1 2.9 8.2 0.0 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain UCH PF00443.29 ETO31556.1 - 1.6e-72 244.1 3.2 1.4e-70 237.7 0.1 3.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUSP PF06337.12 ETO31556.1 - 3.9e-06 27.4 0.1 3.9e-06 27.4 0.1 3.5 3 0 0 3 3 1 1 DUSP domain Afi1 PF07792.12 ETO31556.1 - 0.0038 17.7 2.9 0.0038 17.7 2.9 3.0 3 0 0 3 3 3 1 Docking domain of Afi1 for Arf3 in vesicle trafficking Tim54 PF11711.8 ETO31556.1 - 0.0067 15.3 12.6 0.24 10.1 7.3 2.4 2 0 0 2 2 2 2 Inner membrane protein import complex subunit Tim54 RP-C_C PF11800.8 ETO31556.1 - 0.032 14.3 13.1 0.22 11.6 0.8 3.3 3 0 0 3 3 3 0 Replication protein C C-terminal region SpoIIP PF07454.11 ETO31556.1 - 0.054 12.9 17.0 0.056 12.9 4.9 2.4 2 0 0 2 2 2 0 Stage II sporulation protein P (SpoIIP) Folate_carrier PF01770.18 ETO31556.1 - 0.5 9.0 10.2 0.11 11.2 2.5 2.3 2 0 0 2 2 2 0 Reduced folate carrier Zip PF02535.22 ETO31556.1 - 0.78 8.9 12.1 0.6 9.3 1.2 2.3 2 0 0 2 2 2 0 ZIP Zinc transporter Gti1_Pac2 PF09729.9 ETO31556.1 - 1.2 9.2 23.6 0.72 9.9 7.3 2.8 3 0 0 3 3 3 0 Gti1/Pac2 family PBP_sp32 PF07222.12 ETO31556.1 - 2.3 7.6 13.5 0.027 13.9 5.1 2.0 2 0 0 2 2 2 0 Proacrosin binding protein sp32 Ctr PF04145.15 ETO31556.1 - 6 7.5 9.9 0.88 10.2 0.6 2.8 2 0 0 2 2 2 0 Ctr copper transporter family RNA_pol_Rpc4 PF05132.14 ETO31556.1 - 7.5 7.0 17.9 1.7 9.1 6.5 2.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 Connexin PF00029.19 ETO31556.1 - 7.7 6.2 15.8 0.12 12.1 5.4 2.4 2 0 0 2 2 2 0 Connexin DUF4834 PF16118.5 ETO31556.1 - 7.9 7.5 25.2 0.093 13.7 3.3 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) Pox_Ag35 PF03286.14 ETO31556.1 - 9.4 6.0 31.0 0.19 11.5 12.1 2.6 2 0 0 2 2 2 0 Pox virus Ag35 surface protein RPA43_OB PF17875.1 ETO31556.1 - 9.8 6.8 12.5 1.2 9.8 0.6 3.5 3 0 0 3 3 3 0 RPA43 OB domain in RNA Pol I Mad3_BUB1_I PF08311.12 ETO31557.1 - 0.0013 18.7 1.4 0.0036 17.3 0.6 2.0 1 1 1 2 2 2 1 Mad3/BUB1 homology region 1 MutS_II PF05188.17 ETO31557.1 - 0.072 13.4 0.0 0.39 11.0 0.0 2.2 2 0 0 2 2 2 0 MutS domain II DUF3194 PF11419.8 ETO31557.1 - 0.14 12.5 0.0 0.52 10.7 0.0 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3194) MMR_HSR1_Xtn PF16897.5 ETO31558.1 - 0.0046 16.9 1.5 0.73 9.9 0.2 2.2 2 0 0 2 2 2 2 C-terminal region of MMR_HSR1 domain DUF1319 PF07028.11 ETO31558.1 - 0.058 13.6 0.4 0.35 11.1 0.1 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF1319) PHA-1 PF06542.11 ETO31560.1 - 0.029 13.2 0.1 0.032 13.1 0.1 1.1 1 0 0 1 1 1 0 Regulator protein PHA-1 Atg14 PF10186.9 ETO31562.1 - 0.002 17.3 4.7 0.0028 16.8 4.7 1.1 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 Bap31_Bap29_C PF18035.1 ETO31562.1 - 0.01 15.8 0.8 0.027 14.5 0.8 1.7 1 0 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain Apolipoprotein PF01442.18 ETO31562.1 - 0.013 15.3 5.6 0.024 14.5 5.6 1.4 1 0 0 1 1 1 0 Apolipoprotein A1/A4/E domain TMF_TATA_bd PF12325.8 ETO31562.1 - 0.015 15.5 6.1 0.16 12.2 6.1 2.2 1 1 0 1 1 1 0 TATA element modulatory factor 1 TATA binding FAM76 PF16046.5 ETO31562.1 - 0.019 14.3 7.8 0.025 13.9 7.8 1.1 1 0 0 1 1 1 0 FAM76 protein KxDL PF10241.9 ETO31562.1 - 0.021 15.1 1.1 0.021 15.1 1.1 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein FlaC_arch PF05377.11 ETO31562.1 - 0.027 14.8 4.6 0.099 13.0 0.3 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) HIT PF01230.23 ETO31562.1 - 0.029 15.1 0.7 21 5.9 0.0 2.9 3 0 0 3 3 3 0 HIT domain SAM_3 PF18016.1 ETO31562.1 - 0.038 13.8 0.1 0.18 11.6 0.0 2.2 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO31562.1 - 0.038 14.1 2.2 3.1 8.0 0.1 2.8 2 1 1 3 3 3 0 SAM domain (Sterile alpha motif) kleA_kleC PF17383.2 ETO31562.1 - 0.041 14.2 0.5 0.1 13.0 0.3 1.8 1 1 0 1 1 1 0 Uncharacterized KorC regulated protein A Syntaxin_2 PF14523.6 ETO31562.1 - 0.23 11.9 9.0 0.28 11.6 7.6 1.9 1 1 0 1 1 1 0 Syntaxin-like protein YtxH PF12732.7 ETO31562.1 - 0.24 12.0 5.0 2.7 8.6 0.8 2.9 3 0 0 3 3 3 0 YtxH-like protein GrpE PF01025.19 ETO31562.1 - 0.25 11.0 4.9 0.46 10.1 4.9 1.4 1 0 0 1 1 1 0 GrpE ALMT PF11744.8 ETO31562.1 - 0.34 9.7 4.1 0.41 9.4 4.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Synaptobrevin PF00957.21 ETO31562.1 - 0.6 9.9 4.8 2.5 8.0 3.0 2.6 1 1 1 2 2 2 0 Synaptobrevin Ank PF00023.30 ETO31563.1 - 0.00078 19.8 0.1 0.44 11.1 0.0 3.4 3 0 0 3 3 3 1 Ankyrin repeat DUF3671 PF12420.8 ETO31563.1 - 0.0088 16.1 2.1 0.036 14.2 1.0 2.2 2 0 0 2 2 2 1 Protein of unknown function Ycf70 PF17382.2 ETO31563.1 - 0.11 12.9 0.9 8.9 6.8 0.0 2.6 2 0 0 2 2 2 0 Uncharacterized Ycf70-like FixQ PF05545.11 ETO31563.1 - 0.15 12.0 0.1 0.15 12.0 0.1 2.5 3 0 0 3 3 3 0 Cbb3-type cytochrome oxidase component FixQ Ank_2 PF12796.7 ETO31563.1 - 0.17 12.5 0.0 4.5 7.9 0.0 2.5 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) DUF4279 PF14106.6 ETO31564.1 - 0.043 14.0 0.1 1 9.6 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4279) MTS_N PF08468.11 ETO31564.1 - 0.073 13.1 0.9 4.3 7.4 0.0 3.0 3 0 0 3 3 3 0 Methyltransferase small domain N-terminal Transgly PF00912.22 ETO31565.1 - 0.027 13.9 1.6 0.044 13.2 1.6 1.3 1 0 0 1 1 1 0 Transglycosylase Phage_antitermQ PF06530.12 ETO31565.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.5 1 0 0 1 1 1 0 Phage antitermination protein Q CDC45 PF02724.14 ETO31565.1 - 2.7 6.2 26.1 0.93 7.7 18.1 2.0 2 0 0 2 2 2 0 CDC45-like protein BSP_II PF05432.11 ETO31565.1 - 3 7.5 30.1 0.039 13.7 20.0 2.1 2 0 0 2 2 2 0 Bone sialoprotein II (BSP-II) PHD PF00628.29 ETO31566.1 - 1.8e-06 27.7 2.7 6.8e-06 25.9 2.7 1.9 1 0 0 1 1 1 1 PHD-finger WAPL PF07814.13 ETO31566.1 - 9.2e-06 24.7 1.1 9.2e-06 24.7 1.1 1.5 2 0 0 2 2 2 1 Wings apart-like protein regulation of heterochromatin zf-HC5HC2H_2 PF13832.6 ETO31566.1 - 0.0047 17.1 3.7 0.017 15.2 2.7 2.3 1 1 1 2 2 2 1 PHD-zinc-finger like domain PHD_2 PF13831.6 ETO31566.1 - 0.0069 15.9 0.6 0.017 14.7 0.0 1.9 2 0 0 2 2 2 1 PHD-finger Zn_ribbon_17 PF17120.5 ETO31566.1 - 0.053 13.1 1.6 0.11 12.1 1.6 1.5 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type VWA_N2 PF16164.5 ETO31566.1 - 0.091 12.9 4.7 0.25 11.5 0.7 2.7 2 0 0 2 2 2 0 VWA N-terminal C1_2 PF03107.16 ETO31566.1 - 0.13 12.6 3.4 0.29 11.5 3.4 1.6 1 0 0 1 1 1 0 C1 domain zf-RING_11 PF17123.5 ETO31566.1 - 0.74 9.6 6.9 1.6 8.6 6.9 1.6 1 0 0 1 1 1 0 RING-like zinc finger zf-rbx1 PF12678.7 ETO31566.1 - 1 9.7 5.7 0.41 11.0 2.3 2.1 2 0 0 2 2 2 0 RING-H2 zinc finger domain zf-PHD-like PF15446.6 ETO31566.1 - 1.9 8.1 9.2 0.11 12.1 1.7 2.6 3 0 0 3 3 3 0 PHD/FYVE-zinc-finger like domain NACHT PF05729.12 ETO31567.1 - 3.3e-08 33.6 0.0 7e-08 32.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain ABC_tran PF00005.27 ETO31567.1 - 0.011 16.3 0.1 0.011 16.3 0.1 2.9 3 0 0 3 3 3 0 ABC transporter RNA_helicase PF00910.22 ETO31567.1 - 0.023 15.1 0.7 0.11 12.9 0.1 2.7 2 1 0 2 2 2 0 RNA helicase AAA_22 PF13401.6 ETO31567.1 - 0.042 14.1 2.8 0.05 13.9 0.1 2.7 3 1 0 3 3 3 0 AAA domain DUF4727 PF15856.5 ETO31567.1 - 0.065 12.8 0.1 0.17 11.4 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4727) DR2241 PF18069.1 ETO31568.1 - 0.14 12.0 0.8 0.42 10.5 0.8 1.8 1 0 0 1 1 1 0 DR2241 stabilising domain Xin PF08043.12 ETO31569.1 - 0.22 11.2 1.3 5.8 6.7 0.0 2.9 3 0 0 3 3 3 0 Xin repeat TMEM215 PF15746.5 ETO31570.1 - 0.023 14.1 1.2 0.031 13.7 1.2 1.2 1 0 0 1 1 1 0 TMEM215 family Zn_ribbon_SprT PF17283.2 ETO31570.1 - 0.043 13.7 0.8 0.13 12.1 0.8 1.9 1 0 0 1 1 1 0 SprT-like zinc ribbon domain zf-H2C2_2 PF13465.6 ETO31570.1 - 8.8 7.0 7.0 32 5.2 0.5 2.4 1 1 1 2 2 2 0 Zinc-finger double domain TraB PF01963.17 ETO31571.1 - 3.7e-06 27.0 0.1 5.3e-06 26.5 0.1 1.2 1 0 0 1 1 1 1 TraB family Oscp1 PF10188.9 ETO31571.1 - 0.034 14.3 0.1 0.072 13.2 0.1 1.5 1 1 0 1 1 1 0 Organic solute transport protein 1 Pox_polyA_pol_N PF12630.7 ETO31571.1 - 3.6 8.0 12.9 0.42 11.0 5.6 2.6 2 1 1 3 3 3 0 Poxvirus poly(A) polymerase N-terminal domain Lebercilin PF15619.6 ETO31572.1 - 0.031 13.9 15.5 0.04 13.6 15.5 1.0 1 0 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease Pkinase PF00069.25 ETO31573.1 - 3.7e-55 187.1 0.0 6e-55 186.5 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31573.1 - 3e-29 102.1 0.0 4.8e-29 101.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO31573.1 - 0.00013 21.4 0.0 0.00034 20.0 0.0 1.6 1 1 1 2 2 2 1 Kinase-like RIO1 PF01163.22 ETO31573.1 - 0.0032 17.1 3.5 0.038 13.6 0.2 2.3 2 0 0 2 2 2 2 RIO1 family ASCH PF04266.14 ETO31573.1 - 0.0055 17.3 0.4 4.6 7.9 0.0 2.3 2 0 0 2 2 2 2 ASCH domain PRT_C PF08372.10 ETO31575.1 - 0.12 12.1 0.8 0.22 11.2 0.8 1.3 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal Shugoshin_N PF07558.11 ETO31577.1 - 0.0041 17.0 9.7 0.014 15.2 9.7 2.0 1 0 0 1 1 1 1 Shugoshin N-terminal coiled-coil region APG6_N PF17675.1 ETO31577.1 - 0.0064 17.0 25.9 0.0068 16.9 11.6 2.2 1 1 1 2 2 2 1 Apg6 coiled-coil region RasGAP_C PF03836.15 ETO31577.1 - 0.0098 16.0 19.7 0.019 15.1 6.3 2.2 2 0 0 2 2 2 1 RasGAP C-terminus DUF4140 PF13600.6 ETO31577.1 - 0.01 16.2 10.0 0.53 10.8 2.1 2.3 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) Leu_zip PF15294.6 ETO31577.1 - 0.011 15.2 25.0 0.021 14.3 11.2 2.1 1 1 0 2 2 2 0 Leucine zipper TTR-52 PF01060.23 ETO31577.1 - 0.021 15.5 0.6 1.3 9.8 0.1 2.8 3 0 0 3 3 3 0 Transthyretin-like family DivIC PF04977.15 ETO31577.1 - 0.024 14.4 7.7 0.024 14.4 7.7 3.0 2 1 0 2 2 2 0 Septum formation initiator TPR_MLP1_2 PF07926.12 ETO31577.1 - 0.072 13.2 26.9 0.46 10.5 22.4 2.3 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein BRE1 PF08647.11 ETO31577.1 - 0.086 12.9 26.2 0.27 11.3 8.8 3.0 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase BST2 PF16716.5 ETO31577.1 - 0.12 13.0 24.5 0.076 13.6 4.3 2.6 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 Fis1_TPR_C PF14853.6 ETO31577.1 - 0.13 12.3 0.1 0.13 12.3 0.1 2.9 3 0 0 3 3 2 0 Fis1 C-terminal tetratricopeptide repeat Jnk-SapK_ap_N PF09744.9 ETO31577.1 - 0.14 12.3 27.4 0.56 10.4 9.9 2.9 1 1 2 3 3 3 0 JNK_SAPK-associated protein-1 Fez1 PF06818.15 ETO31577.1 - 0.18 12.3 20.7 0.41 11.1 20.4 1.8 1 1 0 1 1 1 0 Fez1 TMF_TATA_bd PF12325.8 ETO31577.1 - 0.35 11.1 21.3 1.4 9.2 6.5 2.8 2 1 0 3 3 3 0 TATA element modulatory factor 1 TATA binding FlxA PF14282.6 ETO31577.1 - 0.46 10.5 27.7 0.081 12.9 11.2 2.6 2 1 0 2 2 2 0 FlxA-like protein Prefoldin PF02996.17 ETO31577.1 - 0.5 10.3 14.8 0.53 10.2 4.2 2.8 2 0 0 2 2 2 0 Prefoldin subunit Cep57_MT_bd PF06657.13 ETO31577.1 - 0.52 10.8 11.5 3.2 8.2 4.1 3.1 2 1 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 Lebercilin PF15619.6 ETO31577.1 - 0.53 9.9 27.1 0.44 10.2 9.9 2.3 1 1 1 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease bZIP_1 PF00170.21 ETO31577.1 - 0.55 10.4 15.4 0.11 12.6 7.5 3.0 2 1 1 3 3 3 0 bZIP transcription factor HALZ PF02183.18 ETO31577.1 - 0.61 10.3 14.6 0.4 11.0 2.2 3.7 2 2 2 4 4 4 0 Homeobox associated leucine zipper Spc7 PF08317.11 ETO31577.1 - 0.71 8.7 26.2 1.4 7.8 9.1 2.1 1 1 0 2 2 2 0 Spc7 kinetochore protein APC_N_CC PF16689.5 ETO31577.1 - 0.88 9.7 14.3 0.28 11.3 6.0 3.6 3 1 0 3 3 2 0 Coiled-coil N-terminus of APC, dimerisation domain ADIP PF11559.8 ETO31577.1 - 1.1 9.3 27.5 1.5 8.9 6.7 2.5 1 1 0 2 2 2 0 Afadin- and alpha -actinin-Binding CENP-F_leu_zip PF10473.9 ETO31577.1 - 1.2 9.2 24.6 0.17 11.9 11.2 2.4 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF1664 PF07889.12 ETO31577.1 - 1.5 8.9 15.4 3.6 7.7 3.5 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF4472 PF14739.6 ETO31577.1 - 1.5 9.6 22.7 7.4 7.4 10.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) HrpB7 PF09486.10 ETO31577.1 - 1.5 9.1 13.0 0.12 12.7 4.2 2.3 1 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) DUF2205 PF10224.9 ETO31577.1 - 2.2 8.4 14.5 7.8 6.6 1.5 3.1 2 1 0 2 2 2 0 Short coiled-coil protein Enkurin PF13864.6 ETO31577.1 - 2.2 8.8 17.1 0.84 10.1 9.5 2.5 1 1 1 2 2 2 0 Calmodulin-binding KASH_CCD PF14662.6 ETO31577.1 - 2.6 7.8 30.3 0.85 9.4 16.2 2.2 1 1 1 2 2 2 0 Coiled-coil region of CCDC155 or KASH JIP_LZII PF16471.5 ETO31577.1 - 2.7 8.2 14.7 0.2 11.9 5.0 2.9 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II WXG100 PF06013.12 ETO31577.1 - 3.2 8.1 14.2 5.8 7.2 3.4 3.2 3 1 0 3 3 2 0 Proteins of 100 residues with WXG DUF3450 PF11932.8 ETO31577.1 - 3.3 6.9 25.1 0.18 11.1 10.3 2.2 1 1 0 2 2 2 0 Protein of unknown function (DUF3450) DUF4795 PF16043.5 ETO31577.1 - 3.5 7.2 24.3 3.7 7.1 13.5 2.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4795) Snapin_Pallidin PF14712.6 ETO31577.1 - 3.6 8.1 21.4 3.9 7.9 6.4 3.1 2 1 0 2 2 2 0 Snapin/Pallidin Rootletin PF15035.6 ETO31577.1 - 3.8 7.5 23.8 6.1 6.8 23.8 1.4 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion FAA_hydro_N_2 PF18288.1 ETO31577.1 - 4.4 7.8 5.7 6.9 7.2 0.2 2.6 3 0 0 3 3 2 0 Fumarylacetoacetase N-terminal domain 2 CENP-H PF05837.12 ETO31577.1 - 4.7 7.6 20.3 0.89 10.0 6.5 2.6 2 1 0 2 2 2 0 Centromere protein H (CENP-H) Cytochrom_C_2 PF01322.20 ETO31577.1 - 5 8.0 9.6 0.72 10.8 2.1 2.2 1 1 1 2 2 2 0 Cytochrome C' DUF4407 PF14362.6 ETO31577.1 - 5.2 6.3 16.1 7.7 5.8 16.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF724 PF05266.14 ETO31577.1 - 5.7 6.7 19.4 3.3 7.5 4.9 2.3 1 1 0 2 2 2 0 Protein of unknown function (DUF724) DUF4239 PF14023.6 ETO31577.1 - 6.3 6.5 8.7 1.4 8.6 4.5 1.9 1 1 0 2 2 2 0 Protein of unknown function (DUF4239) Spc24 PF08286.11 ETO31577.1 - 6.9 7.0 23.9 0.76 10.0 8.8 3.2 2 1 1 3 3 3 0 Spc24 subunit of Ndc80 YabA PF06156.13 ETO31577.1 - 7 7.4 20.7 4.1 8.1 6.5 2.7 1 1 1 2 2 2 0 Initiation control protein YabA Cnn_1N PF07989.11 ETO31577.1 - 7.9 6.7 22.4 2.8 8.2 6.2 4.1 1 1 1 3 3 3 0 Centrosomin N-terminal motif 1 MAD PF05557.13 ETO31578.1 - 2.6e-14 52.6 4.1 1.5e-12 46.7 3.2 2.0 2 0 0 2 2 2 2 Mitotic checkpoint protein TolA_bind_tri PF16331.5 ETO31578.1 - 0.0009 19.3 0.5 1.1 9.4 0.0 2.4 1 1 1 2 2 2 2 TolA binding protein trimerisation HOOK PF05622.12 ETO31578.1 - 0.001 17.4 1.9 0.0014 16.9 1.9 1.2 1 0 0 1 1 1 1 HOOK protein FlxA PF14282.6 ETO31578.1 - 0.0011 19.0 0.8 0.0024 17.8 0.8 1.6 1 0 0 1 1 1 1 FlxA-like protein Fez1 PF06818.15 ETO31578.1 - 0.0011 19.5 2.1 0.0014 19.1 2.1 1.2 1 0 0 1 1 1 1 Fez1 TPR_MLP1_2 PF07926.12 ETO31578.1 - 0.0024 17.9 2.3 0.0046 17.0 2.3 1.5 1 0 0 1 1 1 1 TPR/MLP1/MLP2-like protein DUF2408 PF10303.9 ETO31578.1 - 0.0068 17.0 3.7 0.0074 16.9 2.8 1.5 2 0 0 2 2 1 1 Protein of unknown function (DUF2408) bZIP_1 PF00170.21 ETO31578.1 - 0.009 16.1 0.6 0.009 16.1 0.6 3.0 3 1 0 3 3 2 1 bZIP transcription factor DUF2353 PF09789.9 ETO31578.1 - 0.023 14.1 0.3 0.023 14.1 0.3 2.5 1 1 2 3 3 3 0 Uncharacterized coiled-coil protein (DUF2353) TBCA PF02970.16 ETO31578.1 - 0.049 14.0 2.1 0.37 11.2 1.9 2.3 1 1 0 1 1 1 0 Tubulin binding cofactor A PilJ PF13675.6 ETO31578.1 - 0.095 12.7 0.1 0.35 10.9 0.1 2.0 2 0 0 2 2 2 0 Type IV pili methyl-accepting chemotaxis transducer N-term Csm1_N PF18504.1 ETO31578.1 - 0.1 12.9 5.5 0.83 10.0 0.3 3.1 2 1 0 2 2 2 0 Csm1 N-terminal domain Erp_C PF06780.11 ETO31578.1 - 0.12 12.4 4.7 0.2 11.6 3.7 1.7 1 1 1 2 2 2 0 Erp protein C-terminus APC_N_CC PF16689.5 ETO31578.1 - 0.18 11.9 8.5 5.8 7.1 0.4 3.3 3 0 0 3 3 3 0 Coiled-coil N-terminus of APC, dimerisation domain HMMR_C PF15908.5 ETO31578.1 - 0.18 12.1 9.4 2.3 8.5 0.5 2.3 1 1 1 2 2 2 0 Hyaluronan mediated motility receptor C-terminal ADIP PF11559.8 ETO31578.1 - 0.19 11.8 5.3 0.32 11.1 5.3 1.3 1 0 0 1 1 1 0 Afadin- and alpha -actinin-Binding Rootletin PF15035.6 ETO31578.1 - 0.19 11.7 4.9 3.7 7.5 4.9 2.5 1 1 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion SOGA PF11365.8 ETO31578.1 - 0.25 12.5 3.8 0.5 11.5 0.4 2.5 1 1 1 2 2 2 0 Protein SOGA Spc24 PF08286.11 ETO31578.1 - 0.25 11.6 7.3 0.15 12.3 1.4 2.5 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 JIP_LZII PF16471.5 ETO31578.1 - 0.26 11.5 4.7 0.4 10.9 0.1 2.7 3 0 0 3 3 3 0 JNK-interacting protein leucine zipper II bZIP_2 PF07716.15 ETO31578.1 - 0.31 11.1 4.6 1.4 9.0 0.1 3.2 3 0 0 3 3 3 0 Basic region leucine zipper Atg14 PF10186.9 ETO31578.1 - 0.39 9.7 5.8 0.53 9.3 5.8 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 GAS PF13851.6 ETO31578.1 - 0.77 9.1 9.9 1.4 8.2 9.9 1.5 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding Cnn_1N PF07989.11 ETO31578.1 - 3.7 7.8 10.7 4.1 7.6 0.4 2.9 2 1 1 3 3 3 0 Centrosomin N-terminal motif 1 WD40 PF00400.32 ETO31580.1 - 3.1e-25 88.0 15.3 4.9e-09 36.7 0.6 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31580.1 - 2.6e-09 37.3 0.2 0.0058 16.9 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31580.1 - 7.3e-06 24.9 1.7 0.0044 15.7 0.7 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 SR-25 PF10500.9 ETO31581.1 - 1.9 8.1 37.5 1.3 8.5 17.6 2.1 1 1 0 2 2 2 0 Nuclear RNA-splicing-associated protein Pkinase PF00069.25 ETO31583.1 - 3.9e-06 26.4 0.0 6.3e-06 25.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain DUF2205 PF10224.9 ETO31583.1 - 0.95 9.5 6.0 0.31 11.0 1.4 2.2 2 0 0 2 2 2 0 Short coiled-coil protein Pkinase PF00069.25 ETO31584.1 - 5.9e-18 65.2 0.2 6.5e-18 65.0 0.2 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31584.1 - 3.1e-13 49.6 0.1 3.3e-13 49.5 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase SmpB PF01668.18 ETO31584.1 - 0.024 14.5 1.8 0.032 14.1 1.8 1.1 1 0 0 1 1 1 0 SmpB protein DNA_methylase PF00145.17 ETO31585.1 - 2.1e-39 135.8 0.0 3.3e-39 135.2 0.0 1.3 1 1 0 1 1 1 1 C-5 cytosine-specific DNA methylase Piwi PF02171.17 ETO31586.1 - 7.5e-30 104.2 0.9 1.1e-24 87.2 0.9 2.3 2 1 0 2 2 2 2 Piwi domain CSG2 PF16965.5 ETO31586.1 - 0.23 10.3 1.7 0.32 9.9 1.7 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator ORC_WH_C PF18137.1 ETO31586.1 - 0.3 11.2 6.9 2.1 8.4 1.5 2.2 2 0 0 2 2 2 0 Origin recognition complex winged helix C-terminal SAP18 PF06487.12 ETO31586.1 - 2.1 8.5 5.1 15 5.7 5.1 2.1 1 1 0 1 1 1 0 Sin3 associated polypeptide p18 (SAP18) zf-C2H2_3rep PF18868.1 ETO31586.1 - 3.5 8.3 7.5 5.4 7.7 0.5 2.4 1 1 1 2 2 2 0 Zinc finger C2H2-type, 3 repeats Presenilin PF01080.17 ETO31586.1 - 4.2 6.0 7.6 6 5.5 7.6 1.1 1 0 0 1 1 1 0 Presenilin Coilin_N PF15862.5 ETO31586.1 - 6.5 6.6 16.4 3.9 7.3 5.9 2.2 2 0 0 2 2 2 0 Coilin N-terminus Phosphoesterase PF04185.14 ETO31587.1 - 6e-49 167.1 0.0 6.9e-48 163.6 0.0 2.1 1 1 0 1 1 1 1 Phosphoesterase family RGS PF00615.19 ETO31588.1 - 0.024 14.9 0.3 0.26 11.5 0.3 2.5 1 1 0 1 1 1 0 Regulator of G protein signaling domain Caveolin PF01146.17 ETO31588.1 - 0.9 9.5 5.5 2 8.4 5.5 1.5 1 0 0 1 1 1 0 Caveolin ParBc_2 PF08857.11 ETO31589.1 - 2e-42 145.1 0.2 3.3e-42 144.4 0.2 1.4 1 0 0 1 1 1 1 Putative ParB-like nuclease RRM_1 PF00076.22 ETO31590.1 - 1.2e-23 82.7 0.2 4.6e-14 52.0 0.1 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO31590.1 - 4.9e-05 23.2 0.5 0.0075 16.2 0.1 2.4 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif DUF4651 PF15513.6 ETO31590.1 - 4.9e-05 23.1 0.1 0.7 9.8 0.0 3.3 2 1 1 3 3 3 2 Domain of unknown function (DUF4651) PHM7_cyt PF14703.6 ETO31590.1 - 0.00047 20.4 3.9 0.54 10.5 2.2 3.4 2 1 0 2 2 2 2 Cytosolic domain of 10TM putative phosphate transporter Phage_TAC_13 PF16459.5 ETO31590.1 - 0.0038 17.6 0.0 1.2 9.6 0.0 2.5 2 1 0 2 2 2 2 Phage tail assembly chaperone, TAC DUF1699 PF08004.11 ETO31590.1 - 0.033 13.9 0.1 8.3 6.1 0.0 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF1699) TFIIB PF00382.19 ETO31592.1 - 4.8e-22 77.8 0.0 1.2e-10 41.2 0.0 2.4 2 0 0 2 2 2 2 Transcription factor TFIIB repeat TFIIB_C_1 PF18542.1 ETO31592.1 - 0.0011 18.9 0.2 0.3 11.1 0.0 2.5 2 0 0 2 2 2 2 Transcription factor IIB C-terminal module 1 HOIP-UBA PF16678.5 ETO31592.1 - 0.048 13.7 0.8 1.9 8.5 0.1 2.7 2 1 1 3 3 3 0 HOIP UBA domain pair DotA PF11388.8 ETO31592.1 - 0.071 13.3 0.9 0.34 11.2 0.1 2.3 3 0 0 3 3 3 0 Phagosome trafficking protein DotA RB_B PF01857.20 ETO31592.1 - 0.12 12.4 0.9 0.28 11.2 0.8 1.6 1 1 0 1 1 1 0 Retinoblastoma-associated protein B domain FancD2 PF14631.6 ETO31593.1 - 0.0047 14.4 7.3 0.0061 14.0 7.3 1.1 1 0 0 1 1 1 1 Fanconi anaemia protein FancD2 nuclease DUF4820 PF16091.5 ETO31593.1 - 0.062 12.7 5.2 0.086 12.2 5.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4746 PF15928.5 ETO31593.1 - 0.16 11.3 7.2 0.21 10.9 7.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) RNA_pol_Rpc4 PF05132.14 ETO31593.1 - 0.23 11.9 7.1 0.36 11.3 7.1 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Presenilin PF01080.17 ETO31593.1 - 0.48 9.1 4.9 0.58 8.9 4.9 1.2 1 0 0 1 1 1 0 Presenilin TFIIF_alpha PF05793.12 ETO31593.1 - 0.51 8.9 28.3 0.73 8.4 28.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) DUF913 PF06025.12 ETO31593.1 - 0.65 8.9 3.4 0.69 8.8 3.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) NPR3 PF03666.13 ETO31593.1 - 0.72 8.6 14.4 0.98 8.1 14.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 DUF3827 PF12877.7 ETO31593.1 - 1.8 6.8 10.5 2.5 6.4 10.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Vfa1 PF08432.10 ETO31593.1 - 2.7 8.3 18.1 6 7.2 18.1 1.6 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Rtf2 PF04641.12 ETO31593.1 - 3 7.1 17.5 5 6.4 17.5 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger NARP1 PF12569.8 ETO31593.1 - 3.1 6.6 14.0 4.5 6.1 14.0 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CCDC106 PF15794.5 ETO31593.1 - 3.5 7.3 18.4 1.1 9.0 15.7 1.4 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 TLD PF07534.16 ETO31594.1 - 1.4e-17 64.2 2.0 2.2e-17 63.6 2.0 1.2 1 0 0 1 1 1 1 TLD HSP70 PF00012.20 ETO31595.1 - 0.012 13.8 0.3 0.11 10.6 0.0 1.9 1 1 1 2 2 2 0 Hsp70 protein zf-CCCH_3 PF15663.5 ETO31595.1 - 0.11 12.7 0.0 0.16 12.2 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger containing family Kelch_6 PF13964.6 ETO31596.1 - 2.4e-07 30.8 2.4 0.79 10.1 0.3 4.5 5 0 0 5 5 5 3 Kelch motif Kelch_2 PF07646.15 ETO31596.1 - 4.3e-07 29.7 3.9 0.0083 16.1 0.8 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO31596.1 - 1.5e-05 24.9 0.1 0.00052 20.0 0.1 3.1 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO31596.1 - 1.6e-05 24.4 0.9 0.028 14.0 0.3 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO31596.1 - 0.0014 18.6 3.0 1.8 8.7 0.0 4.2 4 0 0 4 4 4 1 Kelch motif N_Asn_amidohyd PF14736.6 ETO31596.1 - 0.083 12.0 0.1 2.7 7.1 0.1 2.1 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Peptidase_M48 PF01435.18 ETO31597.1 - 1.1e-14 54.6 0.0 1.9e-14 53.9 0.0 1.4 1 0 0 1 1 1 1 Peptidase family M48 TAF4 PF05236.14 ETO31598.1 - 0.014 15.2 13.6 0.02 14.7 13.6 1.2 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Zip PF02535.22 ETO31598.1 - 0.02 14.1 10.8 0.022 14.0 10.8 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter RNase_H2_suC PF08615.11 ETO31598.1 - 0.15 12.3 13.9 5.7 7.1 13.9 2.0 1 1 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) Merozoite_SPAM PF07133.11 ETO31598.1 - 0.25 11.3 28.2 0.36 10.8 28.2 1.2 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) Pkinase_fungal PF17667.1 ETO31598.1 - 0.3 9.8 8.1 0.36 9.6 8.1 1.1 1 0 0 1 1 1 0 Fungal protein kinase TFIIA PF03153.13 ETO31598.1 - 0.4 10.6 25.2 0.47 10.4 25.2 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF4746 PF15928.5 ETO31598.1 - 0.53 9.7 20.2 0.73 9.2 20.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DDHD PF02862.17 ETO31598.1 - 0.6 10.2 9.0 0.91 9.6 9.0 1.4 1 0 0 1 1 1 0 DDHD domain DUF913 PF06025.12 ETO31598.1 - 0.63 9.0 8.3 0.69 8.8 8.3 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) LAP1C PF05609.12 ETO31598.1 - 1.2 8.2 18.5 1.3 8.0 18.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Lin-8 PF03353.15 ETO31598.1 - 1.4 8.4 21.2 1.8 8.1 21.2 1.2 1 0 0 1 1 1 0 Ras-mediated vulval-induction antagonist OATP PF03137.20 ETO31598.1 - 1.5 7.0 3.5 1.8 6.7 3.5 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family O-antigen_lig PF13425.6 ETO31598.1 - 2.1 7.0 10.0 2.3 6.9 10.0 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Pex14_N PF04695.13 ETO31598.1 - 2.3 8.9 16.0 2.8 8.6 16.0 1.2 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Ndc1_Nup PF09531.10 ETO31598.1 - 2.3 6.8 13.1 2.8 6.5 13.1 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SLC12 PF03522.15 ETO31598.1 - 2.9 6.8 17.2 3.4 6.6 17.2 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PepSY_TM PF03929.16 ETO31598.1 - 3 7.4 4.7 3.4 7.3 4.7 1.1 1 0 0 1 1 1 0 PepSY-associated TM region Fungal_trans_2 PF11951.8 ETO31598.1 - 3.6 6.3 12.4 3.8 6.2 7.2 2.0 1 1 1 2 2 2 0 Fungal specific transcription factor domain ALMT PF11744.8 ETO31598.1 - 4.5 6.0 12.6 5.1 5.8 12.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter CLN3 PF02487.17 ETO31598.1 - 4.5 6.2 10.2 5 6.1 10.2 1.2 1 0 0 1 1 1 0 CLN3 protein CDC45 PF02724.14 ETO31598.1 - 6.1 5.0 21.3 7.1 4.8 21.3 1.0 1 0 0 1 1 1 0 CDC45-like protein Pinin_SDK_memA PF04696.13 ETO31598.1 - 6.4 6.9 31.5 1.3 9.1 21.5 2.2 1 1 1 2 2 2 0 pinin/SDK/memA/ protein conserved region PAT1 PF09770.9 ETO31598.1 - 6.7 4.8 22.4 7.9 4.6 22.4 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Otopetrin PF03189.13 ETO31598.1 - 7.1 5.3 7.8 7.2 5.3 7.8 1.1 1 0 0 1 1 1 0 Otopetrin SID-1_RNA_chan PF13965.6 ETO31598.1 - 7.2 4.9 7.9 9.6 4.5 7.9 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 V_ATPase_I PF01496.19 ETO31598.1 - 7.9 4.2 16.1 8.9 4.1 16.1 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Membralin PF09746.9 ETO31598.1 - 8.9 5.2 14.8 11 5.0 14.8 1.0 1 0 0 1 1 1 0 Tumour-associated protein Neur_chan_memb PF02932.16 ETO31598.1 - 9.5 6.2 15.1 11 5.9 15.1 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO31598.1 - 10 4.8 21.8 12 4.6 21.8 1.1 1 0 0 1 1 1 0 Presenilin POPLD PF08170.12 ETO31599.1 - 0.078 13.3 0.3 0.078 13.3 0.3 1.6 2 0 0 2 2 2 0 POPLD (NUC188) domain DUF2197 PF09963.9 ETO31601.1 - 0.04 14.2 0.0 0.11 12.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2197) MerR-DNA-bind PF09278.11 ETO31602.1 - 0.29 11.7 5.1 1.7 9.2 0.3 2.5 2 0 0 2 2 2 0 MerR, DNA binding HTH_44 PF14641.6 ETO31603.1 - 4.3e-11 43.3 3.1 1.4e-10 41.6 3.1 2.0 1 0 0 1 1 1 1 Helix-turn-helix DNA-binding domain of SPT6 Pkinase PF00069.25 ETO31604.1 - 5.2e-17 62.1 0.3 3.6e-11 42.9 0.2 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31604.1 - 3.4e-08 33.1 0.2 3.3e-06 26.6 0.1 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO31604.1 - 0.00026 20.4 0.1 0.00046 19.6 0.1 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO31604.1 - 0.0083 14.9 0.0 0.016 14.0 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase Choline_kinase PF01633.20 ETO31604.1 - 0.084 12.4 1.5 0.14 11.7 1.5 1.4 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ETO31604.1 - 0.11 12.4 0.1 0.19 11.6 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family SSP160 PF06933.11 ETO31604.1 - 0.25 9.5 8.5 0.47 8.6 8.5 1.3 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Haspin_kinase PF12330.8 ETO31604.1 - 0.88 8.4 4.7 0.17 10.8 0.4 1.9 2 0 0 2 2 2 0 Haspin like kinase domain Peptidase_C14 PF00656.22 ETO31606.1 - 3.3e-14 53.4 1.3 7e-14 52.4 1.3 1.5 1 1 0 1 1 1 1 Caspase domain NblA PF04485.12 ETO31606.1 - 0.00061 20.1 0.3 0.00061 20.1 0.3 2.0 2 0 0 2 2 2 1 Phycobilisome degradation protein nblA Phage_int_SAM_4 PF13495.6 ETO31606.1 - 0.083 13.4 0.3 0.35 11.4 0.2 2.1 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain WD40 PF00400.32 ETO31607.1 - 2.2e-35 120.0 24.9 9.8e-07 29.4 0.6 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31607.1 - 1.6e-09 37.9 2.8 0.17 12.2 0.0 5.7 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31607.1 - 4.2e-07 29.0 9.6 0.0044 15.7 0.2 5.5 2 2 3 6 6 6 5 Nucleoporin Nup120/160 Peptidase_C9 PF01707.16 ETO31607.1 - 0.05 13.2 0.7 8.5 5.9 0.1 4.0 4 1 1 5 5 5 0 Peptidase family C9 WD40 PF00400.32 ETO31609.1 - 2.2e-34 116.9 33.1 3.6e-06 27.6 0.0 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31609.1 - 1.3e-09 38.2 2.3 0.0058 16.9 0.0 6.2 6 1 1 7 7 7 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31609.1 - 1e-06 27.7 8.6 0.34 9.5 0.0 4.6 1 1 3 5 5 5 4 Nucleoporin Nup120/160 UpxZ PF06603.11 ETO31609.1 - 0.088 13.1 0.2 25 5.2 0.0 2.7 2 0 0 2 2 2 0 UpxZ family of transcription anti-terminator antagonists WD40 PF00400.32 ETO31610.1 - 1.3e-32 111.3 31.6 1.1e-06 29.2 0.2 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO31610.1 - 1.1e-09 37.6 7.2 0.24 10.0 0.1 5.0 3 2 1 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO31610.1 - 1.2e-07 31.9 3.7 0.84 10.0 0.4 4.5 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain MS_channel PF00924.18 ETO31611.1 - 0.026 14.0 0.4 0.041 13.4 0.4 1.3 1 0 0 1 1 1 0 Mechanosensitive ion channel DUF4286 PF14114.6 ETO31611.1 - 0.26 11.8 3.5 0.48 10.9 0.2 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4286) La PF05383.17 ETO31612.1 - 2.8e-17 62.5 0.0 6.2e-17 61.4 0.0 1.6 1 0 0 1 1 1 1 La domain RRM_1 PF00076.22 ETO31612.1 - 3.3e-07 30.0 0.0 0.0033 17.2 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO31612.1 - 0.0082 16.0 0.0 0.091 12.6 0.0 2.4 2 0 0 2 2 2 1 Occluded RNA-recognition motif DOMON PF03351.17 ETO31614.1 - 0.00013 22.2 0.5 0.00026 21.2 0.5 1.5 1 1 0 1 1 1 1 DOMON domain Ion_trans PF00520.31 ETO31616.1 - 1.4e-23 83.4 1.5 1.9e-23 83.0 1.5 1.2 1 0 0 1 1 1 1 Ion transport protein DUF3671 PF12420.8 ETO31616.1 - 0.96 9.5 5.0 2.5 8.2 0.9 2.5 2 0 0 2 2 2 0 Protein of unknown function Pkinase PF00069.25 ETO31617.1 - 8.9e-09 35.1 0.0 1.1e-08 34.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31617.1 - 0.00072 18.9 0.0 0.00085 18.7 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase DUF1947 PF09183.10 ETO31617.1 - 0.036 14.3 0.2 0.06 13.6 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF1947) Pkinase PF00069.25 ETO31618.1 - 1.3e-45 155.8 0.1 3.8e-45 154.3 0.1 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31618.1 - 1.8e-30 106.1 0.1 3.6e-30 105.1 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO31618.1 - 0.00064 19.1 0.0 0.0012 18.2 0.0 1.5 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO31618.1 - 0.12 12.2 0.1 0.76 9.6 0.0 2.1 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF2569 PF10754.9 ETO31619.1 - 0.022 15.2 0.1 0.043 14.3 0.1 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2569) DpnI PF06044.12 ETO31619.1 - 0.046 13.4 1.0 0.34 10.5 1.0 2.1 1 1 1 2 2 2 0 Dam-replacing family O-antigen_lig PF13425.6 ETO31619.1 - 0.049 12.4 0.3 0.076 11.8 0.3 1.2 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Adeno_E3_CR2 PF02439.15 ETO31619.1 - 0.16 11.7 0.2 0.29 10.9 0.2 1.4 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 TMEMspv1-c74-12 PF11044.8 ETO31619.1 - 0.5 10.4 4.8 0.15 12.0 1.2 1.9 2 0 0 2 2 2 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein Serinc PF03348.15 ETO31619.1 - 0.69 8.8 4.4 7.8 5.3 4.4 2.0 1 1 0 1 1 1 0 Serine incorporator (Serinc) Ank_2 PF12796.7 ETO31621.1 - 1.3e-09 38.5 1.6 1.2e-05 25.8 0.1 3.5 3 0 0 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO31621.1 - 1.1e-06 28.5 0.7 0.15 12.7 0.0 4.7 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO31621.1 - 0.001 19.6 0.6 0.099 13.3 0.2 3.3 3 0 0 3 3 3 1 Ankyrin repeats (many copies) SUIM_assoc PF16619.5 ETO31621.1 - 0.0047 17.0 1.9 0.019 15.0 1.9 2.1 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Ank PF00023.30 ETO31621.1 - 0.0087 16.5 0.8 6.5 7.4 0.1 4.3 4 0 0 4 4 4 1 Ankyrin repeat DHH PF01368.20 ETO31621.1 - 0.025 14.8 0.0 1.1 9.5 0.0 2.5 2 1 0 2 2 2 0 DHH family DUF4845 PF16137.5 ETO31621.1 - 0.081 13.8 0.8 0.3 12.0 0.6 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4845) Dala_Dala_lig_N PF01820.21 ETO31621.1 - 0.4 11.2 1.6 1 9.9 0.1 2.6 2 1 0 2 2 2 0 D-ala D-ala ligase N-terminus Pan_kinase PF03309.14 ETO31621.1 - 4.3 7.1 6.4 13 5.5 6.4 1.8 1 1 0 1 1 1 0 Type III pantothenate kinase PIP5K PF01504.18 ETO31622.1 - 5.4e-32 111.1 0.4 1e-31 110.2 0.0 1.6 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase Tubulin PF00091.25 ETO31623.1 - 6.9e-35 121.0 0.0 1e-34 120.5 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO31623.1 - 9.1e-35 119.6 0.0 1.5e-34 118.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO31623.1 - 0.15 11.3 0.0 0.22 10.6 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Cpn60_TCP1 PF00118.24 ETO31624.1 - 5e-131 437.7 6.1 5e-113 378.3 4.3 2.0 2 0 0 2 2 2 2 TCP-1/cpn60 chaperonin family DUF4354 PF14263.6 ETO31624.1 - 0.012 15.4 0.5 1.6 8.6 0.0 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4354) LacAB_rpiB PF02502.18 ETO31624.1 - 0.067 13.2 0.2 0.2 11.6 0.2 1.8 1 0 0 1 1 1 0 Ribose/Galactose Isomerase WD40 PF00400.32 ETO31625.1 - 5.1e-07 30.3 1.7 7.3e-06 26.6 0.1 2.6 3 0 0 3 3 3 1 WD domain, G-beta repeat DUF4982 PF16355.5 ETO31625.1 - 0.13 12.3 0.0 0.27 11.2 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4982) Kelch_4 PF13418.6 ETO31626.1 - 1.6e-06 28.0 0.1 4.8e-05 23.3 0.1 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO31626.1 - 7.2e-06 25.5 1.2 1.5e-05 24.5 1.2 1.6 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 ETO31626.1 - 0.0046 16.9 2.3 0.018 15.0 0.5 2.6 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO31626.1 - 0.0058 16.9 0.6 0.044 14.1 0.1 2.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO31626.1 - 0.12 12.3 3.2 0.76 9.8 0.8 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO31627.1 - 0.0016 18.4 1.5 0.061 13.3 0.4 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO31627.1 - 0.0056 16.7 3.1 0.37 10.8 0.1 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO31627.1 - 0.061 12.9 3.6 0.094 12.3 1.1 2.7 2 1 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO31627.1 - 0.18 11.9 0.1 0.99 9.5 0.2 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain Ribosomal_S20p PF01649.18 ETO31629.1 - 0.0094 16.6 0.7 0.0094 16.6 0.7 2.1 3 0 0 3 3 3 1 Ribosomal protein S20 EMC3_TMCO1 PF01956.16 ETO31629.1 - 0.13 12.0 4.2 0.26 11.0 4.2 1.6 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like RPEL PF02755.15 ETO31632.1 - 0.004 16.8 0.3 2.3 8.0 0.0 3.3 2 0 0 2 2 2 2 RPEL repeat FAM184 PF15665.5 ETO31632.1 - 1.1 9.1 67.4 0.042 13.6 15.3 4.4 2 1 2 4 4 4 0 Family with sequence similarity 184, A and B Rab5-bind PF09311.11 ETO31632.1 - 1.1 8.5 59.7 0.043 13.2 44.0 2.5 1 1 1 2 2 2 0 Rabaptin-like protein DnaJ PF00226.31 ETO31633.1 - 2.5e-25 88.4 1.4 4.3e-25 87.6 1.4 1.4 1 0 0 1 1 1 1 DnaJ domain DnaJ_C PF01556.18 ETO31633.1 - 8.3e-25 87.6 0.2 1.1e-24 87.2 0.2 1.2 1 0 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO31633.1 - 1.4e-15 57.4 15.1 2.3e-15 56.7 15.1 1.4 1 0 0 1 1 1 1 DnaJ central domain Anti-TRAP PF15777.5 ETO31633.1 - 6.1e-06 26.1 11.8 0.00027 20.9 0.7 2.4 1 1 1 2 2 2 2 Tryptophan RNA-binding attenuator protein inhibitory protein DUF5351 PF17302.2 ETO31633.1 - 0.069 13.4 18.6 2.7 8.3 0.4 4.3 4 0 0 4 4 4 0 Family of unknown function (DUF5351) A2L_zn_ribbon PF08792.10 ETO31633.1 - 0.31 10.8 11.1 3 7.7 0.1 3.5 2 1 1 3 3 3 0 A2L zinc ribbon domain HypA PF01155.19 ETO31633.1 - 0.47 10.5 9.0 0.54 10.3 0.6 2.4 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf_C2H2_10 PF18414.1 ETO31633.1 - 0.69 9.5 3.1 14 5.3 0.3 2.5 2 0 0 2 2 2 0 C2H2 type zinc-finger PADR1 PF08063.12 ETO31633.1 - 0.92 9.3 5.9 7.6 6.4 3.0 2.4 2 0 0 2 2 2 0 PADR1 (NUC008) domain zf-C4_Topoisom PF01396.19 ETO31633.1 - 1 9.2 5.4 22 5.0 0.1 2.6 2 0 0 2 2 2 0 Topoisomerase DNA binding C4 zinc finger TackOD1 PF18551.1 ETO31633.1 - 1.1 8.9 7.2 2.6 7.7 1.1 2.3 1 1 1 2 2 2 0 Thaumarchaeal output domain 1 zinc_ribbon_9 PF14369.6 ETO31633.1 - 5.4 7.4 15.5 12 6.3 4.1 4.1 3 1 1 4 4 4 0 zinc-ribbon I-EGF_1 PF18372.1 ETO31633.1 - 5.5 7.2 9.5 52 4.1 0.1 2.9 2 1 1 3 3 3 0 Integrin beta epidermal growth factor like domain 1 Zn_Tnp_IS1595 PF12760.7 ETO31633.1 - 5.8 7.0 9.5 20 5.3 6.1 2.6 1 1 1 2 2 2 0 Transposase zinc-ribbon domain DZR PF12773.7 ETO31633.1 - 6 7.0 8.6 22 5.2 8.6 1.9 1 1 0 1 1 1 0 Double zinc ribbon zf-RING_10 PF16685.5 ETO31633.1 - 6.1 7.1 6.6 22 5.2 2.1 2.3 1 1 1 2 2 2 0 zinc RING finger of MSL2 DUF1356 PF07092.12 ETO31633.1 - 9 5.5 7.6 6.1 6.0 0.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1356) SDA1 PF05285.12 ETO31634.1 - 5.6e-05 22.7 9.3 8.2e-05 22.2 9.3 1.2 1 0 0 1 1 1 1 SDA1 BUD22 PF09073.10 ETO31634.1 - 7.1e-05 22.3 9.5 0.0001 21.8 9.5 1.2 1 0 0 1 1 1 1 BUD22 Pkinase PF00069.25 ETO31634.1 - 7.4e-05 22.2 0.0 0.00014 21.3 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain CDC45 PF02724.14 ETO31634.1 - 0.22 9.7 11.6 0.33 9.2 11.6 1.3 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO31634.1 - 2.5 6.2 23.4 4.4 5.4 23.4 1.3 1 0 0 1 1 1 0 Nop14-like family Macoilin PF09726.9 ETO31634.1 - 3.9 5.9 9.8 5.3 5.5 9.8 1.1 1 0 0 1 1 1 0 Macoilin family TolA_bind_tri PF16331.5 ETO31636.1 - 0.001 19.1 4.1 0.001 19.1 4.1 2.2 2 0 0 2 2 2 1 TolA binding protein trimerisation TPR_MLP1_2 PF07926.12 ETO31636.1 - 0.0037 17.3 6.2 0.0037 17.3 6.2 2.2 2 0 0 2 2 2 1 TPR/MLP1/MLP2-like protein MscS_porin PF12795.7 ETO31636.1 - 0.0037 16.8 3.8 0.0037 16.8 3.8 2.0 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain FliJ PF02050.16 ETO31636.1 - 0.0038 17.4 0.9 0.0038 17.4 0.9 2.3 2 0 0 2 2 2 1 Flagellar FliJ protein Bap31_Bap29_C PF18035.1 ETO31636.1 - 0.0043 17.0 8.0 0.0043 17.0 8.0 3.0 2 1 0 2 2 1 1 Bap31/Bap29 cytoplasmic coiled-coil domain ERM PF00769.19 ETO31636.1 - 0.0044 16.9 5.1 0.021 14.6 1.4 2.1 2 0 0 2 2 2 1 Ezrin/radixin/moesin family CC2-LZ PF16516.5 ETO31636.1 - 0.0047 17.3 4.4 0.42 11.0 0.8 2.3 2 0 0 2 2 2 1 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator COG2 PF06148.11 ETO31636.1 - 0.0051 16.9 0.6 0.26 11.4 0.1 2.2 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 FPP PF05911.11 ETO31636.1 - 0.0095 14.2 1.3 0.0095 14.2 1.3 1.7 2 0 0 2 2 2 1 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 ETO31636.1 - 0.011 14.6 2.1 0.011 14.6 2.1 2.1 2 0 0 2 2 2 0 Spc7 kinetochore protein Bacillus_HBL PF05791.11 ETO31636.1 - 0.011 15.5 0.9 0.011 15.5 0.9 2.3 2 1 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ZapB PF06005.12 ETO31636.1 - 0.013 16.0 16.6 0.37 11.3 4.1 2.3 2 0 0 2 2 2 0 Cell division protein ZapB DUF4200 PF13863.6 ETO31636.1 - 0.013 15.9 13.1 0.081 13.3 4.0 2.9 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) COG5 PF10392.9 ETO31636.1 - 0.017 15.3 2.3 0.07 13.3 0.2 2.2 2 0 0 2 2 2 0 Golgi transport complex subunit 5 HMMR_N PF15905.5 ETO31636.1 - 0.017 14.6 8.6 0.028 13.9 2.6 2.1 2 0 0 2 2 2 0 Hyaluronan mediated motility receptor N-terminal Exonuc_VII_L PF02601.15 ETO31636.1 - 0.017 14.7 1.1 0.023 14.3 1.1 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DLP_helical PF18709.1 ETO31636.1 - 0.019 14.2 2.4 0.15 11.2 0.5 2.0 2 0 0 2 2 2 0 Dynamin-like helical domain DUF948 PF06103.11 ETO31636.1 - 0.019 15.2 2.6 4.4 7.6 0.0 2.3 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Lectin_N PF03954.14 ETO31636.1 - 0.021 14.6 1.3 0.021 14.6 1.3 2.0 2 0 0 2 2 2 0 Hepatic lectin, N-terminal domain PRKG1_interact PF15898.5 ETO31636.1 - 0.021 15.7 7.7 0.027 15.4 1.8 2.3 2 0 0 2 2 2 0 cGMP-dependent protein kinase interacting domain CENP-F_leu_zip PF10473.9 ETO31636.1 - 0.027 14.5 4.0 0.027 14.5 4.0 2.2 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 Spc24 PF08286.11 ETO31636.1 - 0.031 14.5 2.1 0.031 14.5 2.1 2.3 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 DUF4140 PF13600.6 ETO31636.1 - 0.031 14.7 1.9 0.46 11.0 0.9 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) DHR10 PF18595.1 ETO31636.1 - 0.033 14.2 6.2 0.033 14.2 6.2 2.1 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Swi5 PF07061.11 ETO31636.1 - 0.036 14.2 7.0 0.36 11.0 3.8 2.4 2 0 0 2 2 2 0 Swi5 Prefoldin_2 PF01920.20 ETO31636.1 - 0.036 14.0 7.1 0.036 14.0 7.1 2.4 2 0 0 2 2 2 0 Prefoldin subunit ADIP PF11559.8 ETO31636.1 - 0.037 14.1 3.2 0.037 14.1 3.2 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding TMF_TATA_bd PF12325.8 ETO31636.1 - 0.037 14.2 7.4 0.065 13.4 1.0 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Csm1_N PF18504.1 ETO31636.1 - 0.038 14.3 5.8 0.038 14.3 5.8 2.3 2 0 0 2 2 2 0 Csm1 N-terminal domain FlaC_arch PF05377.11 ETO31636.1 - 0.038 14.4 8.6 0.046 14.1 1.9 2.6 2 0 0 2 2 2 0 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ETO31636.1 - 0.039 14.0 3.3 0.44 10.6 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 ETO31636.1 - 0.039 13.0 1.0 0.11 11.6 1.0 1.7 1 1 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF3908 PF13048.6 ETO31636.1 - 0.04 14.2 12.3 0.33 11.2 0.2 3.0 2 2 1 3 3 3 0 Protein of unknown function (DUF3908) HIP1_clath_bdg PF16515.5 ETO31636.1 - 0.041 14.5 11.9 0.045 14.4 4.0 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 THOC7 PF05615.13 ETO31636.1 - 0.044 14.1 4.8 0.11 12.8 1.9 2.2 2 0 0 2 2 2 0 Tho complex subunit 7 OmpH PF03938.14 ETO31636.1 - 0.046 14.1 12.1 0.17 12.2 12.1 1.8 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) DUF2730 PF10805.8 ETO31636.1 - 0.051 13.7 1.3 0.25 11.4 0.7 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) APG6_N PF17675.1 ETO31636.1 - 0.054 14.0 13.2 0.063 13.8 4.3 2.4 2 1 0 2 2 2 0 Apg6 coiled-coil region DUF641 PF04859.12 ETO31636.1 - 0.057 13.8 1.3 0.057 13.8 1.3 2.3 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) WXG100 PF06013.12 ETO31636.1 - 0.079 13.2 3.8 0.21 11.8 0.9 2.1 2 0 0 2 2 2 0 Proteins of 100 residues with WXG DivIC PF04977.15 ETO31636.1 - 0.081 12.7 9.9 0.87 9.4 0.4 2.9 2 0 0 2 2 2 0 Septum formation initiator PEP-utilisers_N PF05524.13 ETO31636.1 - 0.091 12.9 1.4 1.4 9.1 0.2 2.2 2 0 0 2 2 2 0 PEP-utilising enzyme, N-terminal KxDL PF10241.9 ETO31636.1 - 0.091 13.0 10.1 0.54 10.6 3.0 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein Nas2_N PF18265.1 ETO31636.1 - 0.097 12.6 1.8 9.7 6.2 0.3 2.5 2 0 0 2 2 2 0 Nas2 N_terminal domain GrpE PF01025.19 ETO31636.1 - 0.11 12.1 8.0 0.18 11.5 2.3 2.1 2 0 0 2 2 2 0 GrpE V-SNARE PF05008.15 ETO31636.1 - 0.14 12.6 10.0 0.33 11.3 1.2 2.4 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus Golgin_A5 PF09787.9 ETO31636.1 - 0.15 11.5 8.8 0.059 12.8 2.3 2.1 2 0 0 2 2 2 0 Golgin subfamily A member 5 COMM_domain PF07258.14 ETO31636.1 - 0.19 11.9 10.8 0.6 10.3 2.6 2.4 2 0 0 2 2 2 0 COMM domain WEMBL PF05701.11 ETO31636.1 - 0.19 10.4 9.0 0.041 12.6 1.4 2.0 2 0 0 2 2 2 0 Weak chloroplast movement under blue light DUF4201 PF13870.6 ETO31636.1 - 0.21 11.3 14.1 0.084 12.6 4.6 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) DUF5082 PF16888.5 ETO31636.1 - 0.24 11.7 6.0 0.22 11.8 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) HSCB_C PF07743.13 ETO31636.1 - 0.26 11.8 6.1 3.5 8.2 0.2 2.3 2 0 0 2 2 2 0 HSCB C-terminal oligomerisation domain DegS PF05384.11 ETO31636.1 - 0.27 10.7 6.9 0.37 10.3 1.4 2.2 2 0 0 2 2 2 0 Sensor protein DegS P4Ha_N PF08336.11 ETO31636.1 - 0.28 11.2 5.6 0.44 10.5 0.8 2.3 2 0 0 2 2 2 0 Prolyl 4-Hydroxylase alpha-subunit, N-terminal region FliD_N PF02465.18 ETO31636.1 - 0.29 11.9 4.1 0.49 11.1 0.9 2.3 2 0 0 2 2 2 0 Flagellar hook-associated protein 2 N-terminus Seryl_tRNA_N PF02403.22 ETO31636.1 - 0.3 11.3 6.4 1.2 9.4 0.4 2.4 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain Tropomyosin_1 PF12718.7 ETO31636.1 - 0.3 11.2 11.0 0.085 13.0 1.9 2.3 2 0 0 2 2 2 0 Tropomyosin like HemX PF04375.14 ETO31636.1 - 0.35 10.1 5.2 0.34 10.1 2.3 1.9 2 0 0 2 2 2 0 HemX, putative uroporphyrinogen-III C-methyltransferase Syntaxin-6_N PF09177.11 ETO31636.1 - 0.35 11.5 6.5 0.72 10.4 2.3 2.2 1 1 1 2 2 2 0 Syntaxin 6, N-terminal UPF0449 PF15136.6 ETO31636.1 - 0.35 11.3 10.5 2.8 8.5 2.2 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 Snapin_Pallidin PF14712.6 ETO31636.1 - 0.38 11.2 9.5 0.097 13.1 4.0 2.2 2 0 0 2 2 2 0 Snapin/Pallidin LapA_dom PF06305.11 ETO31636.1 - 0.4 10.5 0.1 0.4 10.5 0.1 2.9 2 1 0 2 2 2 0 Lipopolysaccharide assembly protein A domain LRRFIP PF09738.9 ETO31636.1 - 0.42 10.0 8.1 0.75 9.2 2.0 2.1 2 0 0 2 2 2 0 LRRFIP family Prefoldin PF02996.17 ETO31636.1 - 0.45 10.4 11.9 0.11 12.4 4.5 2.5 2 0 0 2 2 2 0 Prefoldin subunit DUF4349 PF14257.6 ETO31636.1 - 0.55 9.7 4.9 0.5 9.8 1.4 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Sec2p PF06428.11 ETO31636.1 - 0.56 10.2 12.8 0.14 12.2 4.2 2.4 2 0 0 2 2 2 0 GDP/GTP exchange factor Sec2p YabA PF06156.13 ETO31636.1 - 0.72 10.5 6.4 1.2 9.8 2.0 2.3 2 0 0 2 2 2 0 Initiation control protein YabA SKA1 PF07160.12 ETO31636.1 - 0.74 9.6 6.7 0.12 12.2 1.1 2.0 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 1 CALCOCO1 PF07888.11 ETO31636.1 - 0.81 8.5 7.9 0.086 11.7 1.2 2.0 2 0 0 2 2 2 0 Calcium binding and coiled-coil domain (CALCOCO1) like CEP63 PF17045.5 ETO31636.1 - 0.98 9.3 11.1 0.11 12.4 3.9 2.0 2 0 0 2 2 2 0 Centrosomal protein of 63 kDa Fez1 PF06818.15 ETO31636.1 - 1 9.8 11.0 12 6.2 11.0 2.3 1 1 0 1 1 1 0 Fez1 DUF2681 PF10883.8 ETO31636.1 - 1 9.8 8.5 2.1 8.8 0.2 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF2681) Fib_alpha PF08702.10 ETO31636.1 - 1.1 9.4 6.2 0.85 9.8 1.8 2.1 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 ETO31636.1 - 1.1 8.5 6.1 5.4 6.3 6.5 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) LPP PF04728.13 ETO31636.1 - 1.2 9.6 5.1 0.3 11.5 0.9 2.1 2 0 0 2 2 1 0 Lipoprotein leucine-zipper Nup88 PF10168.9 ETO31636.1 - 1.2 6.8 8.9 0.11 10.2 2.9 1.8 2 0 0 2 2 2 0 Nuclear pore component PYRIN PF02758.16 ETO31636.1 - 1.3 9.3 11.6 1.3 9.2 2.8 3.0 2 1 0 2 2 2 0 PAAD/DAPIN/Pyrin domain Laminin_II PF06009.12 ETO31636.1 - 1.5 8.9 6.0 0.38 10.8 1.9 1.9 2 0 0 2 2 2 0 Laminin Domain II betaPIX_CC PF16523.5 ETO31636.1 - 1.8 8.4 9.9 4.1 7.3 0.7 2.5 2 0 0 2 2 2 0 betaPIX coiled coil CLZ PF16526.5 ETO31636.1 - 1.8 8.9 10.5 0.077 13.4 2.8 2.2 2 0 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Filament PF00038.21 ETO31636.1 - 1.9 8.0 12.4 4.6 6.7 12.4 1.6 1 1 0 1 1 1 0 Intermediate filament protein IFT57 PF10498.9 ETO31636.1 - 2 7.3 10.7 0.98 8.3 3.0 2.1 2 0 0 2 2 2 0 Intra-flagellar transport protein 57 Sas10_Utp3 PF04000.15 ETO31636.1 - 2 9.1 6.6 1.8 9.2 2.9 2.3 2 0 0 2 2 2 0 Sas10/Utp3/C1D family Uso1_p115_C PF04871.13 ETO31636.1 - 2.3 8.6 12.8 1.8 8.9 4.5 2.3 2 0 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region SOAR PF16533.5 ETO31636.1 - 2.3 8.2 7.9 4.2 7.4 3.5 2.4 2 0 0 2 2 2 0 STIM1 Orai1-activating region DUF5320 PF17253.2 ETO31636.1 - 2.9 9.0 5.9 3.8 8.6 1.3 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5320) FlxA PF14282.6 ETO31636.1 - 3.5 7.7 12.9 0.42 10.6 4.5 2.2 2 0 0 2 2 2 0 FlxA-like protein DUF4094 PF13334.6 ETO31636.1 - 3.8 8.0 7.4 1.9 9.0 2.0 2.8 3 0 0 3 3 2 0 Domain of unknown function (DUF4094) Wtap PF17098.5 ETO31636.1 - 3.8 7.4 12.4 11 5.9 5.9 2.7 2 1 0 2 2 2 0 WTAP/Mum2p family Phage_GP20 PF06810.11 ETO31636.1 - 4.1 7.2 16.1 0.053 13.3 4.1 2.4 3 0 0 3 3 2 0 Phage minor structural protein GP20 BicD PF09730.9 ETO31636.1 - 4.3 5.6 11.3 0.17 10.3 4.3 1.8 2 0 0 2 2 2 0 Microtubule-associated protein Bicaudal-D DASH_Duo1 PF08651.10 ETO31636.1 - 4.4 7.1 10.1 15 5.5 3.9 2.9 2 1 0 2 2 2 0 DASH complex subunit Duo1 YlqD PF11068.8 ETO31636.1 - 4.4 7.7 13.5 1.9 8.9 5.8 2.3 2 1 0 2 2 2 0 YlqD protein DUF1043 PF06295.12 ETO31636.1 - 4.5 7.3 10.3 15 5.6 0.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1043) Med4 PF10018.9 ETO31636.1 - 5.1 6.7 7.3 14 5.3 0.4 2.1 2 0 0 2 2 2 0 Vitamin-D-receptor interacting Mediator subunit 4 OEP PF02321.18 ETO31636.1 - 6.2 6.6 9.2 0.51 10.1 3.8 1.7 2 0 0 2 2 1 0 Outer membrane efflux protein bZIP_1 PF00170.21 ETO31636.1 - 6.2 7.0 13.6 0.72 10.0 1.3 2.7 2 1 0 2 2 2 0 bZIP transcription factor DUF812 PF05667.11 ETO31636.1 - 6.8 5.5 13.1 0.37 9.6 4.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF812) Rx_N PF18052.1 ETO31636.1 - 8.5 6.7 7.4 7.5 6.9 1.2 2.8 2 1 0 2 2 2 0 Rx N-terminal domain ABC_tran_CTD PF16326.5 ETO31636.1 - 9 6.6 13.8 6 7.2 4.1 2.5 2 0 0 2 2 2 0 ABC transporter C-terminal domain Adaptin_N PF01602.20 ETO31638.1 - 1.1e-106 357.6 12.9 1.6e-106 357.0 12.9 1.1 1 0 0 1 1 1 1 Adaptin N terminal region Cnd1 PF12717.7 ETO31638.1 - 2e-46 158.0 13.4 3.6e-46 157.2 0.1 3.8 3 1 0 3 3 3 2 non-SMC mitotic condensation complex subunit 1 B2-adapt-app_C PF09066.10 ETO31638.1 - 3.3e-12 46.5 7.4 4.6e-10 39.6 2.1 3.1 2 1 1 3 3 3 2 Beta2-adaptin appendage, C-terminal sub-domain HEAT_2 PF13646.6 ETO31638.1 - 4.7e-12 46.1 0.1 1.7e-05 25.1 0.0 5.0 3 1 1 5 5 5 2 HEAT repeats HEAT PF02985.22 ETO31638.1 - 6.3e-06 26.0 3.6 0.47 10.8 0.0 5.9 6 1 0 6 6 6 1 HEAT repeat RTP1_C1 PF10363.9 ETO31638.1 - 7.4e-05 22.9 2.9 0.17 12.1 0.0 4.2 2 1 1 3 3 3 2 Required for nuclear transport of RNA pol II C-terminus 1 RIX1 PF08167.12 ETO31638.1 - 0.014 15.2 1.6 4 7.1 0.3 2.8 3 0 0 3 3 3 0 rRNA processing/ribosome biogenesis Macoilin PF09726.9 ETO31638.1 - 0.025 13.2 7.6 0.043 12.4 7.6 1.3 1 0 0 1 1 1 0 Macoilin family SoPB_HTH PF18090.1 ETO31638.1 - 0.034 14.3 0.1 6.9 6.9 0.0 2.9 3 0 0 3 3 3 0 Centromere-binding protein HTH domain HEAT_EZ PF13513.6 ETO31638.1 - 0.037 14.5 0.1 11 6.6 0.0 4.9 6 1 0 6 6 6 0 HEAT-like repeat DUF1308 PF07000.11 ETO31638.1 - 0.086 12.8 1.3 15 5.5 0.2 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1308) Arm PF00514.23 ETO31638.1 - 0.089 12.9 0.4 20 5.4 0.0 3.7 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat FANCI_S2 PF14676.6 ETO31638.1 - 5.3 7.3 7.0 41 4.4 1.5 3.7 2 1 2 4 4 4 0 FANCI solenoid 2 WD40 PF00400.32 ETO31639.1 - 1.1e-20 73.5 15.3 3.4e-09 37.2 0.0 5.3 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31639.1 - 7.8e-09 35.7 7.7 0.013 15.7 0.0 5.5 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31639.1 - 0.00091 18.0 7.1 0.0012 17.6 3.5 3.1 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO31639.1 - 0.014 13.9 3.2 1.8 7.0 0.1 3.0 2 1 1 3 3 3 0 Cytochrome D1 heme domain DUF2167 PF09935.9 ETO31640.1 - 1.7 7.8 4.0 0.56 9.3 0.6 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2167) AMPK1_CBM PF16561.5 ETO31641.1 - 0.00011 22.3 0.1 0.00027 21.1 0.1 1.6 1 0 0 1 1 1 1 Glycogen recognition site of AMP-activated protein kinase U3_snoRNA_assoc PF08297.11 ETO31641.1 - 0.069 13.9 1.9 0.069 13.9 1.9 2.4 3 0 0 3 3 3 0 U3 snoRNA associated LZ_Tnp_IS66 PF13007.7 ETO31641.1 - 1.1 10.1 7.8 8.8 7.2 0.0 2.4 1 1 1 2 2 2 0 Transposase C of IS166 homeodomain Kinesin PF00225.23 ETO31642.1 - 5.2e-95 318.2 0.0 5.2e-95 318.2 0.0 2.7 3 0 0 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ETO31642.1 - 6.1e-46 156.1 0.0 6.1e-46 156.1 0.0 3.0 3 0 0 3 3 3 1 Microtubule binding BRE1 PF08647.11 ETO31642.1 - 0.001 19.1 7.3 0.001 19.1 7.3 9.1 5 2 2 9 9 9 1 BRE1 E3 ubiquitin ligase DUF5542 PF17696.1 ETO31642.1 - 0.1 12.8 2.9 0.11 12.6 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5542) Spc7 PF08317.11 ETO31642.1 - 0.25 10.2 126.9 0.026 13.4 24.5 6.4 3 1 4 7 7 7 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 ETO31642.1 - 1.4 8.3 120.3 0.014 14.8 23.7 5.4 1 1 2 4 4 4 0 Golgin subfamily A member 5 Acyltransferase PF01553.21 ETO31643.1 - 0.0097 15.5 0.1 1.6 8.3 0.1 2.2 2 0 0 2 2 2 2 Acyltransferase Tail_VII PF17091.5 ETO31643.1 - 0.025 14.4 0.0 0.061 13.2 0.0 1.6 1 0 0 1 1 1 0 Inovirus G7P protein Aldedh PF00171.22 ETO31645.1 - 1.8e-24 86.1 0.0 6.6e-12 44.7 0.0 3.2 2 1 1 3 3 3 3 Aldehyde dehydrogenase family NRN1 PF15056.6 ETO31645.1 - 0.042 13.9 0.2 0.042 13.9 0.2 2.1 2 0 0 2 2 2 0 Neuritin protein family NAPRTase_C PF17956.1 ETO31645.1 - 0.16 12.4 2.6 1.4 9.3 0.1 3.1 3 0 0 3 3 3 0 Nicotinate phosphoribosyltransferase C-terminal domain Desulfoferrod_N PF06397.12 ETO31646.1 - 0.14 11.8 1.0 0.29 10.8 1.0 1.5 1 0 0 1 1 1 0 Desulfoferrodoxin, N-terminal domain WD40 PF00400.32 ETO31647.1 - 0.074 13.9 0.2 1.6 9.7 0.7 2.9 2 1 0 2 2 2 0 WD domain, G-beta repeat Guanylate_cyc PF00211.20 ETO31648.1 - 1.5e-12 47.6 0.0 2.3e-12 46.9 0.0 1.3 1 0 0 1 1 1 1 Adenylate and Guanylate cyclase catalytic domain IL3Ra_N PF18611.1 ETO31649.1 - 0.056 13.4 0.7 0.056 13.4 0.7 1.9 2 0 0 2 2 2 0 IL-3 receptor alpha chain N-terminal domain PMM PF03332.13 ETO31650.1 - 0.065 13.0 0.5 0.084 12.6 0.5 1.3 1 1 0 1 1 1 0 Eukaryotic phosphomannomutase FtsJ PF01728.19 ETO31650.1 - 0.092 12.9 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 FtsJ-like methyltransferase WD40 PF00400.32 ETO31651.1 - 3.8e-59 195.2 16.1 4.7e-09 36.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31651.1 - 5.2e-20 71.5 2.9 0.0086 16.4 0.0 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31651.1 - 3e-16 59.3 2.6 0.01 14.8 0.1 6.3 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO31651.1 - 3.7e-10 40.0 0.1 5.4e-05 23.2 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO31651.1 - 6e-08 32.4 3.4 0.92 9.5 0.1 6.0 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO31651.1 - 1.7e-05 23.7 9.5 1.2 7.7 0.0 5.8 1 1 5 6 6 6 2 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO31651.1 - 3.4e-05 23.9 0.1 4.8 7.4 0.0 4.2 4 1 0 4 4 4 2 Strictosidine synthase Surfac_D-trimer PF09006.11 ETO31651.1 - 0.00011 22.0 0.0 4 7.4 0.0 4.3 4 0 0 4 4 4 1 Lung surfactant protein D coiled-coil trimerisation Coatomer_WDAD PF04053.14 ETO31651.1 - 0.00014 21.0 1.4 0.43 9.6 0.1 2.7 1 1 2 3 3 3 2 Coatomer WD associated region Proteasome_A_N PF10584.9 ETO31651.1 - 0.00034 20.2 5.8 2.8 7.7 0.0 5.6 6 0 0 6 6 6 1 Proteasome subunit A N-terminal signature PQQ_2 PF13360.6 ETO31651.1 - 0.00091 18.9 0.6 0.088 12.4 0.1 2.6 2 2 0 2 2 2 1 PQQ-like domain DPPIV_N PF00930.21 ETO31651.1 - 0.0016 17.3 0.0 0.4 9.4 0.0 3.1 1 1 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region WD40_like PF17005.5 ETO31651.1 - 0.0018 17.6 1.8 5.8 6.1 0.0 3.1 1 1 1 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 ETO31651.1 - 0.002 16.9 3.2 1.9 7.1 0.1 4.1 1 1 2 3 3 3 2 Nup133 N terminal like Utp8 PF10395.9 ETO31651.1 - 0.0079 14.8 0.3 1.1 7.6 0.1 2.4 1 1 0 2 2 2 2 Utp8 family Gmad1 PF10647.9 ETO31651.1 - 0.0089 15.8 0.0 0.26 11.0 0.0 2.8 2 1 1 3 3 3 1 Lipoprotein LpqB beta-propeller domain DUF4999 PF16390.5 ETO31651.1 - 0.042 14.1 1.3 25 5.2 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function DUF5570 PF17731.1 ETO31651.1 - 0.042 13.9 0.4 5.7 7.1 0.0 3.3 1 1 4 5 5 5 0 Family of unknown function (DUF5570) Ret2_MD PF18528.1 ETO31651.1 - 0.055 13.9 0.1 26 5.3 0.0 3.5 4 1 0 5 5 4 0 RNA editing 3' terminal uridylyl transferase 2 middle domain Cytochrom_D1 PF02239.16 ETO31651.1 - 0.057 11.9 0.8 1.3 7.5 0.0 2.6 1 1 0 2 2 2 0 Cytochrome D1 heme domain DUF1854 PF08909.11 ETO31651.1 - 0.15 11.9 0.3 2.6 7.8 0.0 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF1854) Kelch_1 PF01344.25 ETO31652.1 - 6.1e-06 25.7 3.1 0.029 13.9 0.6 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO31652.1 - 2.8e-05 23.9 1.7 1.5 8.9 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO31652.1 - 0.0001 22.2 0.3 0.053 13.5 0.0 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO31652.1 - 0.00011 22.3 0.4 4.7 7.7 0.0 4.3 5 1 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO31652.1 - 0.00054 19.9 0.3 24 5.1 0.1 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO31652.1 - 0.0076 16.5 0.0 0.076 13.3 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Staphopain_pro PF14731.6 ETO31653.1 - 0.0063 16.5 0.7 0.014 15.4 0.7 1.5 1 0 0 1 1 1 1 Staphopain proregion LptD PF04453.14 ETO31653.1 - 0.019 14.2 4.6 0.025 13.8 4.6 1.1 1 0 0 1 1 1 0 LPS transport system D T2SSJ PF11612.8 ETO31653.1 - 0.025 14.8 0.0 0.033 14.4 0.0 1.1 1 0 0 1 1 1 0 Type II secretion system (T2SS), protein J WD40 PF00400.32 ETO31654.1 - 0.0025 18.6 8.8 0.12 13.3 0.0 4.6 5 0 0 5 5 5 2 WD domain, G-beta repeat Filament PF00038.21 ETO31654.1 - 0.0028 17.3 21.3 0.0028 17.3 21.3 6.2 4 2 2 6 6 6 1 Intermediate filament protein Seryl_tRNA_N PF02403.22 ETO31654.1 - 0.0093 16.2 17.5 0.0093 16.2 17.5 8.8 5 2 5 10 10 10 1 Seryl-tRNA synthetase N-terminal domain AAA_5 PF07728.14 ETO31657.1 - 1.8e-10 40.9 0.0 6.6e-08 32.6 0.0 3.0 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO31657.1 - 3e-10 39.9 0.0 1.2e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA PF00004.29 ETO31657.1 - 3.8e-08 33.8 0.0 2.5e-05 24.7 0.0 2.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO31657.1 - 1.5e-05 25.3 0.0 0.0028 17.9 0.0 2.6 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO31657.1 - 0.00017 22.1 0.1 0.00068 20.2 0.0 2.1 2 0 0 2 2 1 1 ABC transporter AAA_8 PF12780.7 ETO31657.1 - 0.00018 20.9 0.0 0.00052 19.4 0.0 1.8 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_16 PF13191.6 ETO31657.1 - 0.00024 21.6 0.0 0.0017 18.7 0.0 2.2 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO31657.1 - 0.00041 20.3 0.1 0.0009 19.2 0.1 1.6 1 0 0 1 1 1 1 RsgA GTPase AAA_14 PF13173.6 ETO31657.1 - 0.001 19.1 0.0 0.0038 17.3 0.0 2.0 1 0 0 1 1 1 1 AAA domain Viral_helicase1 PF01443.18 ETO31657.1 - 0.0012 18.6 0.0 0.0032 17.2 0.0 1.7 1 0 0 1 1 1 1 Viral (Superfamily 1) RNA helicase Mg_chelatase PF01078.21 ETO31657.1 - 0.0028 17.1 0.1 2 7.7 0.0 3.1 3 0 0 3 3 3 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ETO31657.1 - 0.0028 16.8 0.0 0.0065 15.7 0.0 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF815) MCM PF00493.23 ETO31657.1 - 0.0049 16.0 0.1 0.99 8.5 0.0 3.1 3 1 0 3 3 3 1 MCM P-loop domain PduV-EutP PF10662.9 ETO31657.1 - 0.0056 16.4 0.3 0.035 13.8 0.1 2.1 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation Rad17 PF03215.15 ETO31657.1 - 0.0084 16.0 2.8 0.039 13.9 0.5 2.9 3 2 0 3 3 2 1 Rad17 P-loop domain AAA_2 PF07724.14 ETO31657.1 - 0.0087 16.2 0.0 0.026 14.6 0.0 1.8 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) RNA_helicase PF00910.22 ETO31657.1 - 0.017 15.5 0.2 0.86 10.0 0.1 3.4 3 1 0 3 3 3 0 RNA helicase TsaE PF02367.17 ETO31657.1 - 0.025 14.6 2.6 0.04 13.9 0.0 2.6 3 0 0 3 3 3 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_24 PF13479.6 ETO31657.1 - 0.029 14.1 0.0 0.087 12.5 0.0 1.8 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 ETO31657.1 - 0.037 13.7 0.0 0.68 9.6 0.0 2.7 3 0 0 3 3 3 0 Sigma-54 interaction domain NACHT PF05729.12 ETO31657.1 - 0.049 13.5 0.1 0.36 10.7 0.0 2.4 3 0 0 3 3 3 0 NACHT domain AAA_19 PF13245.6 ETO31657.1 - 0.05 13.9 2.0 2.2 8.6 0.1 3.2 2 1 1 3 3 3 0 AAA domain AAA_3 PF07726.11 ETO31657.1 - 0.055 13.3 0.1 7.3 6.5 0.0 3.3 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) IstB_IS21 PF01695.17 ETO31657.1 - 0.067 12.9 0.0 0.49 10.1 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 ETO31657.1 - 0.11 13.1 0.8 0.4 11.2 0.0 2.4 3 0 0 3 3 2 0 AAA domain Peptidase_C69 PF03577.15 ETO31657.1 - 0.11 11.4 0.1 0.17 10.8 0.1 1.2 1 0 0 1 1 1 0 Peptidase family C69 Sigma54_activ_2 PF14532.6 ETO31657.1 - 0.12 12.5 0.0 1.4 9.0 0.0 2.3 2 0 0 2 2 2 0 Sigma-54 interaction domain AAA_25 PF13481.6 ETO31657.1 - 0.16 11.5 0.1 4.1 6.9 0.0 2.4 2 0 0 2 2 2 0 AAA domain BAF1_ABF1 PF04684.13 ETO31660.1 - 0.0017 17.5 11.9 0.002 17.3 11.9 1.0 1 0 0 1 1 1 1 BAF1 / ABF1 chromatin reorganising factor Menin PF05053.13 ETO31660.1 - 0.16 10.3 8.0 0.19 10.0 8.0 1.0 1 0 0 1 1 1 0 Menin NST1 PF13945.6 ETO31660.1 - 2.5 8.1 13.4 4 7.5 13.4 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator NPR3 PF03666.13 ETO31660.1 - 9.3 4.9 7.9 12 4.6 7.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 OppC_N PF12911.7 ETO31661.1 - 1.3 9.1 4.2 13 5.9 0.3 2.8 2 0 0 2 2 2 0 N-terminal TM domain of oligopeptide transport permease C VWA PF00092.28 ETO31662.1 - 0.012 15.9 0.0 0.018 15.3 0.0 1.2 1 0 0 1 1 1 0 von Willebrand factor type A domain Gly-zipper_Omp PF13488.6 ETO31663.1 - 6.4e-28 96.5 69.5 1.1e-05 25.3 3.8 7.8 1 1 5 6 6 6 6 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO31663.1 - 3.9e-14 52.1 36.3 0.23 11.2 1.5 7.5 1 1 2 3 3 3 3 YMGG-like Gly-zipper Rick_17kDa_Anti PF05433.15 ETO31663.1 - 0.0021 17.9 67.2 0.14 12.0 6.0 9.2 1 1 5 6 6 6 3 Glycine zipper 2TM domain DUF456 PF04306.13 ETO31663.1 - 0.027 14.8 109.7 9.3 6.5 14.0 7.5 1 1 3 4 4 4 0 Protein of unknown function (DUF456) TM_helix PF05552.12 ETO31663.1 - 0.065 13.2 33.4 0.48 10.4 0.7 7.8 1 1 3 4 4 4 0 Conserved TM helix Gly-zipper_OmpA PF13436.6 ETO31663.1 - 0.29 11.0 53.9 6.9e+03 -3.1 14.3 7.1 1 1 1 2 2 2 0 Glycine-zipper domain EFTUD2 PF16004.5 ETO31664.1 - 0.016 15.8 7.4 0.024 15.2 7.4 1.5 1 1 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Menin PF05053.13 ETO31664.1 - 0.039 12.3 5.9 0.042 12.2 5.9 1.0 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO31664.1 - 0.79 8.4 2.5 0.84 8.3 2.5 1.0 1 0 0 1 1 1 0 Presenilin Malic_M PF03949.15 ETO31666.1 - 1.4e-46 158.9 0.0 1.6e-46 158.7 0.0 1.0 1 0 0 1 1 1 1 Malic enzyme, NAD binding domain DUF1002 PF06207.11 ETO31667.1 - 0.53 9.8 14.9 0.62 9.6 14.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1002) Pannexin_like PF12534.8 ETO31667.1 - 0.94 8.5 11.4 1.2 8.2 11.4 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 NPR3 PF03666.13 ETO31667.1 - 3.5 6.3 12.2 3.6 6.3 12.2 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 BIRC6 PF12356.8 ETO31667.1 - 3.9 6.9 6.9 5.2 6.4 6.9 1.3 1 0 0 1 1 1 0 Baculoviral IAP repeat-containing protein 6 DUF2252 PF10009.9 ETO31667.1 - 5.9 5.8 9.2 7.1 5.6 9.2 1.0 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) TERB2 PF15101.6 ETO31667.1 - 6.7 6.7 16.7 8.1 6.4 16.7 1.1 1 0 0 1 1 1 0 Telomere-associated protein TERB2 CDC45 PF02724.14 ETO31667.1 - 7.7 4.7 15.5 7.9 4.6 15.5 1.0 1 0 0 1 1 1 0 CDC45-like protein Zip PF02535.22 ETO31667.1 - 8.9 5.4 7.3 8.3 5.5 7.3 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETO31669.1 - 5.9e-45 150.4 17.8 3.3e-09 37.2 0.2 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31669.1 - 1.1e-19 70.5 3.2 0.0012 19.0 0.0 6.4 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31669.1 - 9.8e-13 47.7 7.4 0.036 13.0 0.1 6.6 2 1 5 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO31669.1 - 0.00032 20.5 6.5 2.3 8.3 0.0 4.8 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO31669.1 - 0.38 10.9 3.2 11 6.2 0.3 3.8 3 1 1 5 5 5 0 Family of unknown function (DUF5570) Kinesin PF00225.23 ETO31672.1 - 1.6e-56 191.7 0.1 1.6e-56 191.7 0.1 1.7 2 0 0 2 2 2 1 Kinesin motor domain COMM_domain PF07258.14 ETO31672.1 - 0.013 15.6 11.7 0.12 12.5 1.4 3.6 4 0 0 4 4 4 0 COMM domain Herpes_BLRF2 PF05812.12 ETO31672.1 - 0.031 14.4 1.1 0.031 14.4 1.1 2.5 3 1 1 4 4 4 0 Herpesvirus BLRF2 protein UPF0242 PF06785.11 ETO31672.1 - 0.032 14.3 0.6 0.032 14.3 0.6 2.2 2 1 0 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus EIF_2_alpha PF07541.12 ETO31672.1 - 0.09 12.9 0.7 0.3 11.2 0.4 2.0 2 0 0 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit DUF4600 PF15372.6 ETO31672.1 - 0.11 12.9 6.3 0.38 11.2 1.9 3.4 3 1 1 4 4 4 0 Domain of unknown function (DUF4600) TSC22 PF01166.18 ETO31672.1 - 3.4 8.1 7.0 14 6.1 0.5 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family ADP_ribosyl_GH PF03747.14 ETO31673.1 - 1.1e-18 68.0 0.1 1.5e-18 67.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylglycohydrolase Kinesin PF00225.23 ETO31674.1 - 5.3e-10 38.7 0.0 7.7e-10 38.2 0.0 1.2 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO31674.1 - 4.9e-07 29.8 0.1 7.3e-07 29.2 0.1 1.2 1 0 0 1 1 1 1 Microtubule binding SmpA_OmlA PF04355.13 ETO31674.1 - 0.0076 16.0 0.0 0.011 15.5 0.0 1.3 1 0 0 1 1 1 1 SmpA / OmlA family SAP18 PF06487.12 ETO31675.1 - 1.9e-30 105.9 0.0 1.9e-30 105.9 0.0 1.4 2 0 0 2 2 2 1 Sin3 associated polypeptide p18 (SAP18) FAM27 PF15832.5 ETO31675.1 - 0.0045 17.5 3.2 0.0083 16.6 3.2 1.4 1 0 0 1 1 1 1 FAM27 D and E protein family CAP59_mtransfer PF11735.8 ETO31677.1 - 0.034 13.8 0.1 0.042 13.5 0.1 1.1 1 0 0 1 1 1 0 Cryptococcal mannosyltransferase 1 MFS_1 PF07690.16 ETO31678.1 - 1.1e-05 24.6 7.6 1.1e-05 24.6 7.6 2.8 1 1 0 2 2 2 1 Major Facilitator Superfamily TRI12 PF06609.13 ETO31678.1 - 0.0001 20.9 1.6 0.0001 20.9 1.6 1.8 2 0 0 2 2 2 1 Fungal trichothecene efflux pump (TRI12) MFS_3 PF05977.13 ETO31678.1 - 0.023 13.1 0.5 0.023 13.1 0.5 1.9 2 0 0 2 2 2 0 Transmembrane secretion effector Insulin_TMD PF17870.1 ETO31678.1 - 1.6 8.9 0.0 1.6 8.9 0.0 4.0 5 0 0 5 5 5 0 Insulin receptor trans-membrane segment DUF4407 PF14362.6 ETO31680.1 - 0.76 9.1 23.7 1.3 8.4 23.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) ABC2_membrane_2 PF12679.7 ETO31680.1 - 1.1 8.4 2.9 1.4 8.1 2.9 1.3 1 0 0 1 1 1 0 ABC-2 family transporter protein CNDH2_C PF16858.5 ETO31680.1 - 3 7.6 30.9 2.1 8.1 28.7 1.8 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Paramyxo_ncap PF00973.19 ETO31681.1 - 0.74 8.7 3.2 0.83 8.5 3.2 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein ALMT PF11744.8 ETO31681.1 - 0.84 8.4 3.1 0.96 8.2 3.1 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Patatin PF01734.22 ETO31682.1 - 6.6e-06 26.4 0.0 1.3e-05 25.5 0.0 1.5 1 0 0 1 1 1 1 Patatin-like phospholipase DUF3336 PF11815.8 ETO31683.1 - 6.9e-49 165.1 4.6 1.2e-48 164.4 4.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3336) Secretin_N_2 PF07655.13 ETO31683.1 - 0.83 10.2 11.1 1.6 9.3 11.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain APG12 PF04110.13 ETO31684.1 - 3.5e-21 75.4 1.6 8.8e-19 67.7 1.6 2.5 1 1 0 1 1 1 1 Ubiquitin-like autophagy protein Apg12 DUF4471 PF14740.6 ETO31684.1 - 0.14 11.3 1.2 0.16 11.1 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) Ank_2 PF12796.7 ETO31685.1 - 2.6e-30 104.8 7.3 8.7e-13 48.7 0.2 3.3 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO31685.1 - 2.6e-25 88.4 0.5 2.9e-08 34.1 0.0 4.2 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ank PF00023.30 ETO31685.1 - 1.3e-21 76.0 0.0 2.3e-06 27.8 0.0 6.2 6 0 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 ETO31685.1 - 3.7e-21 73.0 0.4 0.00013 22.1 0.0 6.6 6 0 0 6 6 6 5 Ankyrin repeat Ank_5 PF13857.6 ETO31685.1 - 9.4e-21 73.6 1.0 5.5e-09 36.1 0.0 4.6 2 1 3 5 5 5 5 Ankyrin repeats (many copies) Ribosomal_S6 PF01250.17 ETO31685.1 - 0.0035 17.6 0.0 0.59 10.4 0.0 2.8 2 1 1 3 3 3 1 Ribosomal protein S6 Ysc84 PF04366.12 ETO31686.1 - 4e-25 88.0 1.0 1.4e-17 63.6 1.1 2.2 2 0 0 2 2 2 2 Las17-binding protein actin regulator Tmpp129 PF10272.9 ETO31687.1 - 0.046 13.0 0.5 3.1 7.0 0.0 2.1 1 1 1 2 2 2 0 Putative transmembrane protein precursor WD40 PF00400.32 ETO31688.1 - 7e-65 213.4 18.9 2.7e-09 37.5 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31688.1 - 3.6e-16 59.2 8.6 0.00075 19.7 0.1 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31688.1 - 4.3e-13 49.3 18.3 2.5e-05 23.8 1.0 3.3 3 0 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO31688.1 - 9.7e-10 37.7 7.2 0.077 11.6 0.0 5.4 2 1 3 6 6 6 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO31688.1 - 0.00029 19.5 0.2 0.095 11.2 0.0 2.7 1 1 1 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO31688.1 - 0.022 14.7 0.0 63 3.7 0.0 4.9 6 0 0 6 6 6 0 PQQ enzyme repeat Me-amine-dh_H PF06433.11 ETO31688.1 - 0.031 13.1 0.1 0.69 8.7 0.0 2.8 2 2 3 5 5 5 0 Methylamine dehydrogenase heavy chain (MADH) WD40 PF00400.32 ETO31689.1 - 6e-45 150.3 23.6 6.7e-07 29.9 1.1 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31689.1 - 2.4e-10 40.6 5.0 0.0037 17.5 0.1 5.6 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO31689.1 - 8e-09 36.1 3.2 4.6e-08 33.6 3.2 2.5 1 0 0 1 1 1 1 TRAF-type zinc finger Ank_5 PF13857.6 ETO31692.1 - 0.0022 18.3 0.0 1.3 9.5 0.0 2.4 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO31692.1 - 0.0048 17.5 0.0 0.5 11.0 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO31692.1 - 0.0067 17.0 0.0 0.013 16.0 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Dicty_REP PF05086.12 ETO31692.1 - 5.1 5.0 8.4 7 4.5 8.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein FSA_C PF10479.9 ETO31692.1 - 6.9 4.7 11.3 9.9 4.1 11.3 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Kelch_1 PF01344.25 ETO31693.1 - 0.012 15.1 0.3 1.1 9.0 0.0 2.5 2 1 0 2 2 2 0 Kelch motif N_Asn_amidohyd PF14736.6 ETO31693.1 - 0.034 13.3 0.0 0.054 12.7 0.0 1.3 1 1 0 1 1 1 0 Protein N-terminal asparagine amidohydrolase WD40 PF00400.32 ETO31694.1 - 5.8e-36 121.9 22.9 5.8e-07 30.1 0.4 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31694.1 - 1.9e-11 44.1 3.1 0.17 12.2 0.1 6.0 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31694.1 - 8.6e-10 37.9 6.7 0.025 13.2 0.2 4.4 2 2 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31694.1 - 1.5e-05 24.5 10.3 0.011 15.1 1.6 4.2 2 2 2 4 4 4 2 WD40-like domain SH3_13 PF18335.1 ETO31694.1 - 0.35 10.7 4.0 4.2 7.3 0.0 3.7 3 1 0 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain WbqC PF08889.11 ETO31695.1 - 0.0033 17.4 1.5 0.0043 17.0 1.5 1.2 1 0 0 1 1 1 1 WbqC-like protein family DUF1689 PF07954.11 ETO31695.1 - 0.0045 17.4 0.8 0.0051 17.2 0.8 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1689) PI3K_1B_p101 PF10486.9 ETO31696.1 - 5.3 4.7 28.0 6.8 4.3 28.0 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit LMBR1 PF04791.16 ETO31696.1 - 6.1 5.6 10.8 7.9 5.3 10.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Peptidase_M14 PF00246.24 ETO31697.1 - 2.4e-08 34.1 0.7 3.1e-08 33.8 0.7 1.2 1 0 0 1 1 1 1 Zinc carboxypeptidase Tetraspanin PF00335.20 ETO31697.1 - 0.039 13.7 0.2 0.039 13.7 0.2 2.1 2 0 0 2 2 2 0 Tetraspanin family Abhydrolase_1 PF00561.20 ETO31699.1 - 0.00013 21.7 0.2 0.056 13.1 0.0 2.4 2 0 0 2 2 2 2 alpha/beta hydrolase fold zf-RanBP PF00641.18 ETO31699.1 - 0.0016 17.7 8.0 0.0042 16.4 8.0 1.7 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others Guanylate_kin PF00625.21 ETO31699.1 - 0.09 12.5 0.1 0.21 11.2 0.1 1.6 1 0 0 1 1 1 0 Guanylate kinase PDEase_I PF00233.19 ETO31700.1 - 2e-32 112.9 0.1 2.9e-32 112.3 0.1 1.1 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Sad1_UNC PF07738.13 ETO31702.1 - 0.066 13.2 0.0 0.32 11.0 0.0 2.0 2 0 0 2 2 2 0 Sad1 / UNC-like C-terminal Pkinase PF00069.25 ETO31703.1 - 5.3e-63 212.8 0.4 4.5e-46 157.4 0.1 2.6 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31703.1 - 3e-40 138.1 0.0 1.9e-33 115.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO31703.1 - 5.9e-07 29.1 0.0 0.00053 19.4 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Haspin_kinase PF12330.8 ETO31703.1 - 0.00096 18.2 0.2 0.00096 18.2 0.2 2.2 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ETO31703.1 - 0.012 14.9 0.1 0.029 13.7 0.1 1.6 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family MIG-14_Wnt-bd PF06664.12 ETO31703.1 - 0.02 14.2 1.0 0.041 13.1 1.0 1.4 1 0 0 1 1 1 0 Wnt-binding factor required for Wnt secretion Pkinase_fungal PF17667.1 ETO31703.1 - 0.024 13.4 0.0 0.024 13.4 0.0 2.3 2 1 0 2 2 2 0 Fungal protein kinase DUF5383 PF17355.2 ETO31704.1 - 8.9 6.7 9.0 9.7 6.6 0.3 3.3 3 0 0 3 3 3 0 Family of unknown function (DUF5383) PIP5K PF01504.18 ETO31705.1 - 3.5e-75 252.8 0.2 7.6e-75 251.7 0.2 1.5 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase PTPlike_phytase PF14566.6 ETO31707.1 - 3e-09 37.2 1.3 1.1e-08 35.4 0.0 2.1 2 0 0 2 2 2 1 Inositol hexakisphosphate ESP PF16590.5 ETO31707.1 - 0.06 13.6 0.3 0.32 11.3 0.2 2.2 2 0 0 2 2 2 0 Exocrine gland-secreting peptide 3-PAP PF12578.8 ETO31707.1 - 0.06 13.1 0.5 0.25 11.1 0.3 2.1 2 0 0 2 2 2 0 Myotubularin-associated protein MMACHC PF16690.5 ETO31708.1 - 3.1e-12 46.6 1.0 1.7e-10 40.9 0.4 2.7 2 1 0 2 2 2 2 Methylmalonic aciduria and homocystinuria type C family MetJ PF01340.20 ETO31709.1 - 0.0084 16.1 0.1 0.026 14.5 0.0 1.9 2 1 0 2 2 2 1 Met Apo-repressor, MetJ DXP_synthase_N PF13292.6 ETO31709.1 - 0.015 14.6 1.1 0.018 14.3 0.4 1.5 1 1 1 2 2 2 0 1-deoxy-D-xylulose-5-phosphate synthase RNA_polI_A34 PF08208.11 ETO31711.1 - 6.3 6.8 34.1 5.6 7.0 24.6 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 TPR_1 PF00515.28 ETO31712.1 - 1.5e-12 46.8 2.0 0.0012 18.6 0.0 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31712.1 - 2.4e-11 42.8 7.3 3.4e-05 23.6 0.2 5.5 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO31712.1 - 2.2e-10 40.2 5.3 0.56 10.7 0.2 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31712.1 - 7.4e-10 38.8 0.4 0.062 14.1 0.0 4.6 2 2 2 4 4 4 3 Tetratricopeptide repeat TPR_19 PF14559.6 ETO31712.1 - 1.9e-09 37.9 0.4 0.0013 19.2 0.0 3.6 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31712.1 - 5e-09 35.7 0.0 0.0033 17.1 0.0 4.0 3 1 1 4 4 3 3 TPR repeat TPR_12 PF13424.6 ETO31712.1 - 1.5e-08 34.8 9.8 3.4e-06 27.2 0.6 3.9 3 1 2 5 5 5 2 Tetratricopeptide repeat SAM_2 PF07647.17 ETO31712.1 - 3e-08 33.7 0.2 1.5e-05 25.0 0.0 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) TPR_8 PF13181.6 ETO31712.1 - 8.4e-08 31.9 0.6 0.011 15.8 0.0 5.3 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO31712.1 - 8.4e-07 29.1 3.5 0.0051 17.0 1.5 2.9 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETO31712.1 - 4.1e-06 26.9 0.5 0.017 15.3 0.0 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31712.1 - 1.1e-05 25.9 0.1 0.019 15.6 0.0 3.9 2 2 1 4 4 4 1 Tetratricopeptide repeat SAM_1 PF00536.30 ETO31712.1 - 1.2e-05 25.7 0.1 0.018 15.5 0.0 2.6 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) TPR_6 PF13174.6 ETO31712.1 - 3.4e-05 24.2 1.1 1.7 9.4 0.0 4.9 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO31712.1 - 0.013 15.0 2.1 0.13 11.6 0.2 2.3 2 0 0 2 2 2 0 MalT-like TPR region Ras PF00071.22 ETO31713.1 - 9.4e-15 54.6 0.3 1.2e-14 54.3 0.3 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO31713.1 - 9e-05 22.7 0.0 0.00015 22.0 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO31713.1 - 0.00017 21.5 0.1 0.00019 21.4 0.1 1.2 1 0 0 1 1 1 1 RsgA GTPase RabGAP-TBC PF00566.18 ETO31714.1 - 4.4e-05 23.2 1.6 6.3e-05 22.7 1.6 1.3 1 0 0 1 1 1 1 Rab-GTPase-TBC domain OTOS PF15182.6 ETO31714.1 - 0.01 15.7 0.8 0.02 14.8 0.2 1.9 2 0 0 2 2 2 0 Otospiralin TMEM238 PF15125.6 ETO31714.1 - 0.034 14.4 0.1 0.19 11.9 0.2 2.2 2 0 0 2 2 2 0 TMEM238 protein family DUF2625 PF10946.8 ETO31714.1 - 0.13 11.3 0.1 0.22 10.6 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function DUF2625 RP-C_C PF11800.8 ETO31716.1 - 8.8 6.4 6.9 1.4 9.0 2.9 1.6 2 0 0 2 2 2 0 Replication protein C C-terminal region DUF5513 PF17632.2 ETO31717.1 - 0.0063 16.9 1.2 0.0078 16.6 0.1 1.7 2 0 0 2 2 2 1 Family of unknown function (DUF5513) DUF5412 PF17428.2 ETO31717.1 - 0.16 11.8 0.2 0.16 11.8 0.2 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5412) Hydrolase_4 PF12146.8 ETO31719.1 - 1.4e-13 50.7 0.0 1.1e-06 28.1 0.0 2.4 2 0 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO31719.1 - 1.7e-06 27.9 0.2 0.0041 16.8 0.1 2.6 3 0 0 3 3 3 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO31719.1 - 3.3e-05 24.6 0.0 0.00021 22.0 0.0 2.0 1 1 0 1 1 1 1 Alpha/beta hydrolase family DLH PF01738.18 ETO31719.1 - 0.012 15.2 0.0 0.5 9.9 0.0 2.3 2 0 0 2 2 2 0 Dienelactone hydrolase family UPF0227 PF05728.12 ETO31719.1 - 0.08 12.9 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0227) NACHT PF05729.12 ETO31721.1 - 0.01 15.7 0.0 0.025 14.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain EF-hand_1 PF00036.32 ETO31722.1 - 3.4e-14 51.2 1.2 1.6e-07 30.4 0.1 2.5 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO31722.1 - 1.9e-11 42.9 0.6 3.3e-05 23.5 0.1 2.6 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO31722.1 - 3.8e-11 43.3 0.2 4.7e-05 23.7 0.1 2.7 3 0 0 3 3 2 2 EF-hand domain pair EF-hand_8 PF13833.6 ETO31722.1 - 5e-10 39.1 0.9 3.7e-05 23.5 0.1 3.0 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO31722.1 - 6e-09 35.0 2.2 0.00025 20.4 0.4 2.6 2 0 0 2 2 2 2 EF hand EF-hand_10 PF14788.6 ETO31722.1 - 0.0046 16.8 0.9 0.2 11.6 0.0 2.6 2 0 0 2 2 2 1 EF hand EF-hand_4 PF12763.7 ETO31722.1 - 0.0089 16.0 0.8 0.28 11.2 0.1 2.8 2 1 1 3 3 3 1 Cytoskeletal-regulatory complex EF hand SAS-6_N PF16531.5 ETO31722.1 - 0.064 13.8 0.8 0.17 12.5 0.8 1.7 1 0 0 1 1 1 0 Centriolar protein SAS N-terminal DUF2633 PF11119.8 ETO31722.1 - 0.37 10.7 0.1 0.37 10.7 0.1 3.3 5 0 0 5 5 2 0 Protein of unknown function (DUF2633) SPARC_Ca_bdg PF10591.9 ETO31722.1 - 0.99 9.8 11.2 6.2 7.2 0.0 3.5 3 1 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region DUF2666 PF10869.8 ETO31722.1 - 7.3 6.8 9.7 0.085 13.1 1.0 2.3 3 0 0 3 3 3 0 Protein of unknown function (DUF2666) WD40 PF00400.32 ETO31723.1 - 1.9e-50 167.7 20.3 6.7e-10 39.4 0.2 7.2 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31723.1 - 4.4e-16 59.0 3.3 0.0001 22.5 0.2 4.6 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31723.1 - 4.5e-13 48.9 1.7 0.067 12.1 0.0 6.6 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO31723.1 - 1.1e-09 38.5 1.9 0.00072 19.5 0.1 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO31723.1 - 1.3e-05 24.0 1.5 0.00086 17.9 0.2 2.9 1 1 1 3 3 3 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO31723.1 - 2e-05 24.1 0.6 0.7 9.2 0.4 3.3 2 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO31723.1 - 0.012 15.5 9.9 6 6.9 0.0 6.4 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat FLgD_tudor PF13861.6 ETO31723.1 - 0.14 12.4 0.1 0.94 9.8 0.0 2.4 4 0 0 4 4 4 0 FlgD Tudor-like domain Proteasome_A_N PF10584.9 ETO31723.1 - 0.22 11.2 4.6 37 4.1 0.0 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature ImmE5 PF11480.8 ETO31723.1 - 0.27 11.7 1.5 15 6.2 0.0 3.3 2 2 1 3 3 3 0 Colicin-E5 Imm protein TRM PF02005.16 ETO31724.1 - 3.9e-16 59.2 0.0 1.2e-14 54.3 0.0 2.1 1 1 0 1 1 1 1 N2,N2-dimethylguanosine tRNA methyltransferase zf-CCCH PF00642.24 ETO31724.1 - 0.00017 21.4 7.2 0.0003 20.6 7.2 1.4 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO31724.1 - 0.0012 18.8 10.5 0.0012 18.8 10.5 2.0 2 0 0 2 2 2 1 Zinc finger domain zf-CCCH_4 PF18044.1 ETO31724.1 - 0.0029 17.4 6.4 0.0029 17.4 6.4 2.2 2 0 0 2 2 2 1 CCCH-type zinc finger Torus PF16131.5 ETO31724.1 - 0.007 17.0 1.3 0.007 17.0 1.3 2.7 3 0 0 3 3 3 1 Torus domain DDHD PF02862.17 ETO31724.1 - 0.011 15.8 0.6 0.12 12.5 0.1 2.0 2 0 0 2 2 2 0 DDHD domain Secretin_N_2 PF07655.13 ETO31724.1 - 3.9 8.1 29.7 2.2 8.9 9.6 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain Transposase_31 PF04754.12 ETO31726.1 - 6.1e-43 146.8 0.2 8.4e-43 146.4 0.2 1.1 1 0 0 1 1 1 1 Putative transposase, YhgA-like DDE_Tnp_1_3 PF13612.6 ETO31726.1 - 3.8e-25 88.7 0.1 7.6e-25 87.7 0.1 1.4 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_1 PF01609.21 ETO31726.1 - 0.0064 16.2 0.0 0.012 15.3 0.0 1.3 1 0 0 1 1 1 1 Transposase DDE domain DDE_Tnp_IS1595 PF12762.7 ETO31727.1 - 2.6e-24 86.0 0.1 7.6e-24 84.5 0.1 1.8 1 1 0 1 1 1 1 ISXO2-like transposase domain Zn_Tnp_IS1595 PF12760.7 ETO31727.1 - 3.4e-05 23.7 8.0 3.4e-05 23.7 8.0 1.8 2 0 0 2 2 2 1 Transposase zinc-ribbon domain Sigma70_r4_2 PF08281.12 ETO31727.1 - 0.0057 16.3 0.0 0.01 15.5 0.0 1.5 1 0 0 1 1 1 1 Sigma-70, region 4 zinc_ribbon_12 PF11331.8 ETO31727.1 - 0.8 9.6 4.0 2.6 7.9 0.9 2.5 1 1 1 2 2 2 0 Probable zinc-ribbon domain zf-H2C2_2 PF13465.6 ETO31727.1 - 0.81 10.2 5.1 0.76 10.3 2.5 2.2 2 0 0 2 2 2 0 Zinc-finger double domain TPR_2 PF07719.17 ETO31728.1 - 0.00053 19.9 0.5 0.073 13.2 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31728.1 - 0.043 13.6 1.0 0.33 10.9 0.2 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO31728.1 - 0.046 14.1 0.1 0.12 12.9 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_21 PF09976.9 ETO31728.1 - 0.052 13.3 0.0 0.087 12.5 0.0 1.3 1 0 0 1 1 1 0 Tetratricopeptide repeat-like domain TPR_16 PF13432.6 ETO31728.1 - 0.095 13.4 0.0 0.18 12.5 0.0 1.4 1 0 0 1 1 1 0 Tetratricopeptide repeat tRNA_anti-codon PF01336.25 ETO31728.1 - 0.15 12.1 0.5 0.55 10.3 0.2 2.1 2 0 0 2 2 2 0 OB-fold nucleic acid binding domain LysM PF01476.20 ETO31729.1 - 9.6e-28 96.0 6.7 6.2e-13 48.6 0.1 4.3 4 0 0 4 4 4 2 LysM domain SecA_DEAD PF07517.14 ETO31729.1 - 1.2e-27 97.0 0.0 2.8e-27 95.7 0.0 1.7 1 0 0 1 1 1 1 SecA DEAD-like domain DUF4225 PF13988.6 ETO31729.1 - 0.0019 17.8 0.4 0.0059 16.2 0.4 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF4225) GPW_gp25 PF04965.14 ETO31729.1 - 0.0085 15.8 0.2 6.1 6.7 0.0 3.5 3 0 0 3 3 3 1 Gene 25-like lysozyme SecA_PP_bind PF01043.20 ETO31729.1 - 0.026 15.2 0.4 0.28 11.8 0.0 3.0 2 0 0 2 2 2 0 SecA preprotein cross-linking domain Herpes_V23 PF01802.17 ETO31730.1 - 0.097 12.1 0.0 0.16 11.4 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus VP23 like capsid protein EF-hand_4 PF12763.7 ETO31730.1 - 0.11 12.5 4.0 4.1 7.4 0.8 2.5 2 0 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand HMw1_D2 PF18254.1 ETO31730.1 - 0.17 12.3 0.4 0.39 11.1 0.4 1.6 1 0 0 1 1 1 0 HMW1 domain 2 Abi_2 PF07751.11 ETO31730.1 - 2.4 8.4 12.9 13 6.0 10.1 2.7 1 1 1 2 2 2 0 Abi-like protein MRNIP PF15749.5 ETO31730.1 - 3.8 8.3 11.7 0.24 12.1 2.9 2.5 3 0 0 3 3 3 0 MRN-interacting protein FAA_hydro_N_2 PF18288.1 ETO31731.1 - 0.089 13.2 0.4 0.3 11.6 0.4 1.9 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal domain 2 WD40 PF00400.32 ETO31733.1 - 5.4e-50 166.3 9.0 4.5e-09 36.8 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31733.1 - 3.7e-20 72.0 0.3 0.0013 18.9 0.0 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31733.1 - 3e-11 42.9 0.1 0.0033 16.5 0.0 4.4 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO31733.1 - 1.1e-08 34.8 2.7 0.021 14.7 0.0 5.3 6 0 0 6 6 6 3 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO31733.1 - 7.3e-06 26.0 0.0 0.00018 21.4 0.0 2.5 1 1 1 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO31733.1 - 7.7e-05 21.5 3.7 0.15 10.7 0.1 3.7 1 1 3 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31733.1 - 0.019 14.3 0.0 1.3 8.3 0.0 2.4 2 0 0 2 2 2 0 WD40-like domain Cytochrom_D1 PF02239.16 ETO31733.1 - 0.02 13.4 0.1 8.3 4.8 0.0 3.0 1 1 2 3 3 3 0 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO31733.1 - 0.026 13.9 0.5 3.3 7.0 0.0 3.3 2 1 2 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO31733.1 - 0.98 9.2 11.9 45 3.8 0.1 5.8 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature B56 PF01603.20 ETO31734.1 - 1.7e-12 47.1 0.2 3e-12 46.2 0.2 1.4 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) DUF3945 PF13101.6 ETO31735.1 - 0.017 14.8 0.0 0.046 13.4 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3945) DUF3449 PF11931.8 ETO31737.1 - 9.9e-60 201.5 2.1 9.9e-60 201.5 2.1 2.5 3 0 0 3 3 3 1 Domain of unknown function (DUF3449) SF3A3 PF16837.5 ETO31737.1 - 3.1e-16 59.6 2.5 7.5e-16 58.4 1.0 2.5 2 1 0 2 2 2 1 Pre-mRNA-splicing factor SF3A3, of SF3a complex, Prp9 zf-C2H2_jaz PF12171.8 ETO31737.1 - 9e-06 25.8 2.0 0.0008 19.6 0.6 2.7 2 0 0 2 2 2 1 Zinc-finger double-stranded RNA-binding SF3a60_bindingd PF12108.8 ETO31737.1 - 0.0087 15.9 0.2 0.0087 15.9 0.2 2.6 3 0 0 3 3 3 1 Splicing factor SF3a60 binding domain zf-met PF12874.7 ETO31737.1 - 0.012 16.0 0.1 0.76 10.3 0.3 2.6 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-C2H2 PF00096.26 ETO31737.1 - 0.019 15.4 2.7 3.7 8.2 0.2 2.8 2 0 0 2 2 2 0 Zinc finger, C2H2 type RNA_pol_Rpb1_3 PF04983.18 ETO31737.1 - 0.11 12.5 0.4 0.26 11.2 0.4 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb1, domain 3 zf-C2H2_4 PF13894.6 ETO31737.1 - 1 10.4 7.0 10 7.2 0.1 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger DUF2892 PF11127.8 ETO31738.1 - 0.45 10.6 5.2 0.16 12.0 1.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2892) Sec7 PF01369.20 ETO31740.1 - 1.8e-45 154.8 6.6 4.1e-45 153.7 6.6 1.6 1 0 0 1 1 1 1 Sec7 domain Sec7_N PF12783.7 ETO31740.1 - 3.3e-32 111.6 3.6 3.3e-32 111.6 3.6 3.2 3 1 1 4 4 4 1 Guanine nucleotide exchange factor in Golgi transport N-terminal Rep_trans PF02486.19 ETO31741.1 - 0.0025 17.6 0.7 0.0032 17.2 0.7 1.1 1 0 0 1 1 1 1 Replication initiation factor RPN2_C PF18004.1 ETO31744.1 - 9.8e-17 61.3 6.5 1.3e-16 60.9 6.5 1.2 1 0 0 1 1 1 1 26S proteasome regulatory subunit RPN2 C-terminal domain Sec62 PF03839.16 ETO31744.1 - 0.35 10.3 3.8 0.43 10.1 3.8 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Ank_2 PF12796.7 ETO31745.1 - 1.4e-11 44.8 1.6 7e-07 29.8 0.0 3.0 2 1 1 3 3 3 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO31745.1 - 1.4e-05 25.0 0.1 0.64 10.8 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ETO31745.1 - 0.00073 19.9 0.2 6.1 7.5 0.0 4.1 4 0 0 4 4 4 2 Ankyrin repeat Ank_4 PF13637.6 ETO31745.1 - 0.0073 16.9 0.2 9.4 7.0 0.0 3.2 3 0 0 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO31745.1 - 0.036 14.4 0.0 5.9 7.3 0.1 3.3 2 1 1 3 3 3 0 Ankyrin repeats (many copies) AAA PF00004.29 ETO31745.1 - 0.17 12.3 1.6 0.45 10.9 1.6 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Not3 PF04065.15 ETO31746.1 - 0.035 13.5 4.4 0.065 12.7 4.4 1.4 1 0 0 1 1 1 0 Not1 N-terminal domain, CCR4-Not complex component HU-CCDC81_bac_2 PF18175.1 ETO31746.1 - 0.15 11.9 1.4 19 5.2 0.2 2.8 2 0 0 2 2 2 0 CCDC81-like prokaryotic HU domain 2 Phage_antitermQ PF06530.12 ETO31748.1 - 0.021 14.7 0.1 0.045 13.6 0.1 1.6 1 0 0 1 1 1 0 Phage antitermination protein Q M11L PF11099.8 ETO31748.1 - 0.038 14.3 1.6 0.091 13.0 1.6 1.6 1 0 0 1 1 1 0 Apoptosis regulator M11L like FliP PF00813.20 ETO31749.1 - 0.07 13.0 0.2 0.12 12.2 0.1 1.4 1 1 0 1 1 1 0 FliP family PRP4 PF08799.11 ETO31752.1 - 2.1e-12 46.4 0.8 2.1e-12 46.4 0.8 2.2 2 0 0 2 2 2 1 pre-mRNA processing factor 4 (PRP4) like KinB_sensor PF16767.5 ETO31752.1 - 0.047 14.2 5.4 5.9 7.4 0.0 3.0 2 1 1 3 3 3 0 Sensor domain of alginate biosynthesis sensor protein KinB Synaptonemal_3 PF15191.6 ETO31752.1 - 0.38 10.6 2.9 23 4.8 0.1 3.1 3 0 0 3 3 3 0 Synaptonemal complex central element protein 3 Spc42p PF11544.8 ETO31752.1 - 1.7 8.7 6.7 0.53 10.3 3.2 2.1 2 1 0 2 2 2 0 Spindle pole body component Spc42p GAS PF13851.6 ETO31752.1 - 3.7 6.9 16.2 2.3 7.5 2.2 2.8 2 1 0 2 2 2 0 Growth-arrest specific micro-tubule binding Bac_small_YrzI PF09501.10 ETO31752.1 - 7.6 6.8 6.7 0.88 9.8 1.4 2.2 2 0 0 2 2 2 0 Probable sporulation protein (Bac_small_yrzI) Beta_helix_2 PF18835.1 ETO31753.1 - 0.059 13.1 0.0 0.16 11.7 0.0 1.7 1 0 0 1 1 1 0 Beta helix repeat of Inulin fructotransferase Ank_4 PF13637.6 ETO31754.1 - 9.1e-06 26.1 0.8 0.065 13.8 0.0 3.9 3 0 0 3 3 3 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO31754.1 - 0.03 14.9 0.2 0.1 13.2 0.1 1.9 1 1 0 1 1 1 0 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO31754.1 - 0.032 14.6 0.3 0.38 11.1 0.0 2.8 2 1 1 3 3 3 0 Ankyrin repeats (many copies) Hexapep_loop PF18776.1 ETO31754.1 - 2.2 8.0 4.7 2.4 7.9 0.1 2.5 2 0 0 2 2 2 0 Hexapeptide repeat including loop XK-related PF09815.9 ETO31754.1 - 2.2 7.3 48.2 0.096 11.7 36.5 3.4 2 1 0 2 2 2 0 XK-related protein CPSase_L_D3 PF02787.19 ETO31755.1 - 1.1 9.6 9.7 4.6 7.6 9.7 2.0 1 1 0 1 1 1 0 Carbamoyl-phosphate synthetase large chain, oligomerisation domain K_trans PF02705.16 ETO31755.1 - 1.2 7.5 2.8 1.3 7.4 2.8 1.2 1 0 0 1 1 1 0 K+ potassium transporter Lactamase_B PF00753.27 ETO31756.1 - 1.1e-05 25.6 0.0 1.7e-05 24.9 0.0 1.4 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETO31756.1 - 0.00037 20.1 0.0 0.00061 19.4 0.0 1.4 1 0 0 1 1 1 1 Beta-lactamase superfamily domain Spc24 PF08286.11 ETO31757.1 - 0.016 15.5 7.8 0.2 11.9 1.8 2.4 1 1 1 2 2 2 0 Spc24 subunit of Ndc80 Phage_GP20 PF06810.11 ETO31757.1 - 0.042 13.7 8.9 0.058 13.2 8.9 1.2 1 0 0 1 1 1 0 Phage minor structural protein GP20 CENP-F_leu_zip PF10473.9 ETO31757.1 - 0.061 13.3 13.7 0.09 12.8 13.7 1.3 1 0 0 1 1 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TMF_TATA_bd PF12325.8 ETO31757.1 - 0.25 11.6 11.5 0.71 10.1 2.8 2.2 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding TPR_MLP1_2 PF07926.12 ETO31757.1 - 0.28 11.2 11.9 2.5 8.2 9.8 2.1 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4472 PF14739.6 ETO31757.1 - 0.37 11.5 13.4 1.7 9.4 12.6 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4472) APG6_N PF17675.1 ETO31757.1 - 0.65 10.5 16.7 3.5 8.2 5.5 2.1 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF724 PF05266.14 ETO31757.1 - 0.75 9.6 13.3 20 5.0 13.3 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Fungal_trans_2 PF11951.8 ETO31757.1 - 0.79 8.5 4.4 0.54 9.0 1.1 1.8 1 1 0 2 2 2 0 Fungal specific transcription factor domain DUF4407 PF14362.6 ETO31757.1 - 1.2 8.4 8.7 1.5 8.1 8.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GPS2_interact PF15784.5 ETO31757.1 - 1.5 9.3 17.5 0.22 12.0 4.2 2.9 1 1 2 3 3 3 0 G-protein pathway suppressor 2-interacting domain YlqD PF11068.8 ETO31757.1 - 2.8 8.3 13.7 1.2 9.5 3.1 2.2 1 1 1 2 2 2 0 YlqD protein zf-HC5HC2H_2 PF13832.6 ETO31758.1 - 1.9e-05 24.7 8.8 2.4e-05 24.4 4.7 2.6 2 0 0 2 2 2 1 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO31758.1 - 3.6e-05 23.9 7.4 3.6e-05 23.9 7.4 2.5 2 0 0 2 2 2 1 PHD-like zinc-binding domain WD40 PF00400.32 ETO31759.1 - 0.017 16.0 12.8 0.64 11.0 0.6 4.3 5 0 0 5 5 5 0 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31759.1 - 0.028 14.7 0.2 0.66 10.3 0.0 2.7 1 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain KH_1 PF00013.29 ETO31760.1 - 5e-12 45.5 1.3 6.9e-12 45.0 1.3 1.2 1 0 0 1 1 1 1 KH domain KH_4 PF13083.6 ETO31760.1 - 0.0012 18.7 0.8 0.0025 17.7 0.5 1.7 1 1 0 1 1 1 1 KH domain KH_2 PF07650.17 ETO31760.1 - 0.0028 17.4 1.7 0.0051 16.6 1.4 1.5 1 1 0 1 1 1 1 KH domain KH_1 PF00013.29 ETO31761.1 - 6.5e-07 29.1 1.1 5.4e-06 26.1 0.1 2.3 2 0 0 2 2 2 1 KH domain KH_4 PF13083.6 ETO31761.1 - 0.00024 20.9 0.0 0.00072 19.4 0.0 1.7 1 0 0 1 1 1 1 KH domain KH_2 PF07650.17 ETO31761.1 - 0.15 11.9 0.1 0.15 11.9 0.1 2.3 2 1 0 2 2 2 0 KH domain Sulfotransfer_3 PF13469.6 ETO31762.1 - 0.00012 22.5 0.7 0.0015 19.0 0.2 2.8 2 1 0 2 2 2 1 Sulfotransferase family POTRA_1 PF08478.10 ETO31762.1 - 0.099 13.0 0.0 0.39 11.1 0.0 2.0 1 0 0 1 1 1 0 POTRA domain, FtsQ-type PCI PF01399.27 ETO31762.1 - 0.41 11.2 8.1 1.7 9.2 0.9 3.2 4 0 0 4 4 4 0 PCI domain DUF3939 PF13075.6 ETO31763.1 - 0.021 14.9 1.8 0.082 12.9 0.2 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3939) SNF2_N PF00176.23 ETO31766.1 - 3.5e-28 98.4 0.0 4.1e-28 98.1 0.0 1.0 1 0 0 1 1 1 1 SNF2 family N-terminal domain RdRP_3 PF00998.23 ETO31766.1 - 0.078 11.7 0.0 0.093 11.4 0.0 1.1 1 0 0 1 1 1 0 Viral RNA dependent RNA polymerase DNA_pol_E_B PF04042.16 ETO31767.1 - 5.5e-32 110.8 0.0 7e-32 110.5 0.0 1.2 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B DUF4275 PF14101.6 ETO31768.1 - 0.071 13.2 0.1 0.11 12.6 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4275) NOA36 PF06524.12 ETO31768.1 - 0.089 12.1 9.2 0.13 11.5 9.2 1.3 1 0 0 1 1 1 0 NOA36 protein FAM60A PF15396.6 ETO31768.1 - 0.96 9.4 6.5 1.3 9.0 6.5 1.2 1 0 0 1 1 1 0 Protein Family FAM60A PNISR PF15996.5 ETO31768.1 - 1.3 9.2 6.2 2 8.7 6.2 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR CYTH PF01928.21 ETO31769.1 - 8e-11 42.2 0.2 1.1e-10 41.7 0.2 1.2 1 0 0 1 1 1 1 CYTH domain DUF3474 PF11960.8 ETO31769.1 - 0.042 14.0 0.3 2.7 8.2 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3474) PhoQ_Sensor PF08918.10 ETO31771.1 - 0.15 11.9 0.1 0.15 11.9 0.1 1.4 2 0 0 2 2 2 0 PhoQ Sensor TetR_C_23 PF17931.1 ETO31771.1 - 0.51 10.5 6.0 0.19 11.8 0.8 2.1 1 1 1 2 2 2 0 Tetracyclin repressor-like, C-terminal domain RCR PF12273.8 ETO31772.1 - 0.28 11.8 1.6 0.66 10.6 1.4 1.9 1 1 1 2 2 2 0 Chitin synthesis regulation, resistance to Congo red DUF3826 PF12875.7 ETO31773.1 - 9e-05 22.7 0.9 0.00013 22.2 0.9 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3826) APOBEC_N PF08210.11 ETO31773.1 - 0.0092 15.9 0.3 0.012 15.5 0.3 1.3 1 0 0 1 1 1 1 APOBEC-like N-terminal domain Exo_endo_phos PF03372.23 ETO31775.1 - 1.1e-06 28.4 0.0 1.3e-06 28.1 0.0 1.1 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ephrin_rec_like PF07699.13 ETO31775.1 - 0.061 13.1 0.3 7.2 6.5 0.1 2.4 2 0 0 2 2 2 0 Putative ephrin-receptor like Tim54 PF11711.8 ETO31776.1 - 0.58 8.9 0.0 0.58 8.9 0.0 3.9 2 1 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 ELMO_CED12 PF04727.13 ETO31777.1 - 1.4e-35 123.0 0.5 1.4e-35 123.0 0.5 1.9 2 0 0 2 2 2 1 ELMO/CED-12 family DUF1943 PF09172.11 ETO31778.1 - 0.0062 15.8 1.4 0.0062 15.8 1.4 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF1943) LEA_2 PF03168.13 ETO31778.1 - 0.025 15.1 5.5 0.093 13.3 5.5 1.9 1 1 0 1 1 1 0 Late embryogenesis abundant protein Bactofilin PF04519.13 ETO31778.1 - 1.2 9.4 10.4 1.3 9.3 8.4 1.9 1 1 0 1 1 1 0 Polymer-forming cytoskeletal TFIIA PF03153.13 ETO31778.1 - 1.3 9.0 16.3 1.6 8.6 16.3 1.2 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit AF-4 PF05110.13 ETO31778.1 - 4.3 5.3 19.4 4.6 5.2 19.4 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein Pheromone PF08015.11 ETO31779.1 - 4.7 8.3 7.0 16 6.6 0.0 2.6 2 1 0 2 2 2 0 Fungal mating-type pheromone RabGAP-TBC PF00566.18 ETO31781.1 - 0.0041 16.8 0.0 0.0043 16.7 0.0 1.2 1 0 0 1 1 1 1 Rab-GTPase-TBC domain Choline_sulf_C PF12411.8 ETO31783.1 - 0.1 12.4 0.1 0.24 11.2 0.1 1.5 1 0 0 1 1 1 0 Choline sulfatase enzyme C terminal zf-TRAF PF02176.18 ETO31785.1 - 3.5e-06 27.6 5.7 3.5e-06 27.6 5.7 2.5 2 0 0 2 2 2 1 TRAF-type zinc finger MAP17 PF15807.5 ETO31785.1 - 1.8 8.8 11.6 0.13 12.5 1.4 2.5 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 WD40 PF00400.32 ETO31786.1 - 0.025 15.4 0.2 0.025 15.4 0.2 2.7 1 1 1 2 2 2 0 WD domain, G-beta repeat BRCA-2_OB1 PF09103.10 ETO31786.1 - 0.083 12.8 0.0 0.17 11.8 0.0 1.4 1 0 0 1 1 1 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 1 DnaJ PF00226.31 ETO31787.1 - 4e-12 46.1 6.3 0.00065 19.8 0.8 4.3 2 2 2 4 4 4 3 DnaJ domain RPT PF13446.6 ETO31787.1 - 0.14 12.1 0.2 7.4 6.6 0.0 2.5 2 0 0 2 2 2 0 A repeated domain in UCH-protein DUF2508 PF10704.9 ETO31791.1 - 0.031 14.4 7.2 1 9.6 0.4 3.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2508) ZZ PF00569.17 ETO31792.1 - 0.0045 16.8 7.9 0.024 14.5 7.9 2.3 1 1 0 1 1 1 1 Zinc finger, ZZ type CUE PF02845.16 ETO31792.1 - 0.012 15.3 0.0 0.021 14.5 0.0 1.4 1 0 0 1 1 1 0 CUE domain BBS2_C PF14782.6 ETO31792.1 - 0.35 9.6 7.5 0.037 12.8 1.0 2.0 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, C-terminal tRNA_synt_1c_R2 PF04557.15 ETO31792.1 - 0.49 11.4 21.2 0.29 12.1 11.5 2.4 2 0 0 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 Prok-RING_1 PF14446.6 ETO31792.1 - 0.82 9.6 10.0 0.6 10.1 5.0 2.6 2 0 0 2 2 2 0 Prokaryotic RING finger family 1 Pkinase PF00069.25 ETO31793.1 - 3.6e-63 213.4 0.0 7e-63 212.5 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31793.1 - 6.3e-25 87.9 0.0 5.2e-24 84.9 0.0 2.0 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO31793.1 - 0.00094 18.6 0.0 0.0015 17.9 0.0 1.4 1 0 0 1 1 1 1 Kinase-like APH PF01636.23 ETO31793.1 - 0.0029 17.6 0.0 0.061 13.2 0.0 2.2 1 1 0 2 2 2 1 Phosphotransferase enzyme family cNMP_binding PF00027.29 ETO31793.1 - 0.067 13.3 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 Cyclic nucleotide-binding domain RNA_pol_3_Rpc31 PF11705.8 ETO31793.1 - 0.12 12.7 17.8 0.04 14.2 15.1 1.6 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 SR-25 PF10500.9 ETO31793.1 - 0.2 11.3 12.9 0.43 10.1 12.9 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4452 PF14618.6 ETO31793.1 - 0.39 10.6 5.1 0.94 9.3 5.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4452) Presenilin PF01080.17 ETO31793.1 - 0.86 8.3 6.0 1.3 7.7 6.0 1.2 1 0 0 1 1 1 0 Presenilin UPF0524 PF15823.5 ETO31793.1 - 7.2 5.9 8.7 17 4.7 8.7 1.5 1 0 0 1 1 1 0 UPF0524 of C3orf70 cNMP_binding PF00027.29 ETO31794.1 - 7.1e-11 42.0 0.0 2.1e-08 34.1 0.0 2.1 1 1 0 1 1 1 1 Cyclic nucleotide-binding domain MdcE PF06833.11 ETO31794.1 - 0.11 12.0 0.0 0.19 11.2 0.0 1.4 1 1 0 1 1 1 0 Malonate decarboxylase gamma subunit (MdcE) Cg6151-P PF10233.9 ETO31795.1 - 0.3 11.4 7.4 0.098 13.0 3.6 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein CG6151-P WD40 PF00400.32 ETO31796.1 - 7.4e-27 93.1 15.2 2.9e-07 31.1 1.3 6.0 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31796.1 - 1.2e-09 38.3 1.2 0.085 13.2 0.0 4.6 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31796.1 - 1.4e-07 31.2 11.1 0.0004 19.8 2.6 4.0 2 2 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO31796.1 - 1.7e-07 30.3 4.1 0.0077 14.9 0.4 3.3 1 1 1 3 3 3 3 Nucleoporin Nup120/160 ERO1 PF04137.15 ETO31797.1 - 3e-54 184.6 0.3 6.4e-54 183.5 0.3 1.4 1 1 0 1 1 1 1 Endoplasmic Reticulum Oxidoreductin 1 (ERO1) EMP24_GP25L PF01105.24 ETO31798.1 - 1.3e-26 93.7 2.7 6.6e-26 91.4 2.7 1.9 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ApoO PF09769.9 ETO31798.1 - 0.16 11.9 0.1 0.35 10.8 0.0 1.6 2 0 0 2 2 2 0 Apolipoprotein O DUF2730 PF10805.8 ETO31798.1 - 0.19 11.8 1.0 2.7 8.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) WD40 PF00400.32 ETO31799.1 - 7.6e-14 51.9 4.0 4.3e-09 36.9 0.7 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31799.1 - 1.8e-06 28.2 0.9 0.08 13.2 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Sof1 PF04158.14 ETO31799.1 - 4.2e-06 27.0 8.3 1.4e-05 25.2 8.3 1.9 1 1 0 1 1 1 1 Sof1-like domain YajC PF02699.15 ETO31799.1 - 0.25 11.2 7.5 1.8 8.5 0.5 2.8 2 1 0 2 2 2 0 Preprotein translocase subunit YMF19 PF02326.15 ETO31799.1 - 3.7 8.4 7.1 11 6.9 7.1 1.8 1 1 0 1 1 1 0 Plant ATP synthase F0 WD40 PF00400.32 ETO31801.1 - 1.9e-35 120.2 28.9 9.2e-07 29.5 0.1 7.5 6 2 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO31801.1 - 1.7e-12 46.8 2.4 0.03 13.0 0.0 5.1 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO31801.1 - 3e-10 40.3 0.5 1.1 9.7 0.0 6.1 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31801.1 - 2.2e-06 27.2 3.5 0.0004 19.8 0.2 3.3 2 1 1 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 ETO31801.1 - 0.0013 17.5 3.4 0.15 10.8 0.0 4.0 3 1 1 4 4 4 1 Nup133 N terminal like WD40 PF00400.32 ETO31803.1 - 2.7e-26 91.3 18.9 1.5e-05 25.6 0.7 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31803.1 - 7.6e-11 42.2 2.2 0.0078 16.5 0.0 5.7 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31803.1 - 1e-07 31.0 7.3 0.0021 16.8 0.1 4.9 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Rootletin PF15035.6 ETO31805.1 - 0.035 14.1 0.1 0.062 13.3 0.1 1.4 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion Apt1 PF10351.9 ETO31807.1 - 2.1e-07 30.2 11.6 0.00012 21.1 5.8 3.1 2 1 1 3 3 3 2 Golgi-body localisation protein domain Solute_trans_a PF03619.16 ETO31809.1 - 3.4e-09 36.6 3.7 4.3e-09 36.3 3.2 1.4 1 1 0 1 1 1 1 Organic solute transporter Ostalpha Polysacc_synt_3 PF13440.6 ETO31809.1 - 0.0048 16.2 1.0 0.0067 15.7 1.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein DUF5381 PF17353.2 ETO31809.1 - 0.069 12.9 2.0 0.071 12.9 0.1 1.8 2 0 0 2 2 2 0 Family of unknown function (DUF5381) Wzy_C PF04932.15 ETO31809.1 - 0.17 11.5 3.1 1.2 8.7 3.1 2.0 1 1 0 1 1 1 0 O-Antigen ligase EptA_B_N PF08019.12 ETO31809.1 - 0.31 10.9 4.2 0.3 11.0 0.3 2.0 2 0 0 2 2 2 0 Phosphoethanolamine transferase EptA/EptB DHHC PF01529.20 ETO31809.1 - 0.71 10.0 7.4 37 4.4 7.2 2.2 1 1 0 1 1 1 0 DHHC palmitoyltransferase DUF3810 PF12725.7 ETO31809.1 - 1.6 8.0 4.3 0.47 9.8 0.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF3810) Voltage_CLC PF00654.20 ETO31811.1 - 8.4e-58 196.3 25.4 1.2e-57 195.8 21.4 2.6 2 1 0 2 2 2 1 Voltage gated chloride channel ThiS PF02597.20 ETO31811.1 - 8.4 7.1 6.0 1.9 9.2 0.2 2.6 2 0 0 2 2 2 0 ThiS family STAT_bind PF02864.15 ETO31812.1 - 0.0072 16.9 0.7 0.0092 16.5 0.7 1.2 1 0 0 1 1 1 1 STAT protein, DNA binding domain Glyco_transf_8 PF01501.20 ETO31812.1 - 0.01 15.4 1.2 0.011 15.3 1.2 1.1 1 0 0 1 1 1 1 Glycosyl transferase family 8 Myosin_head PF00063.21 ETO31813.1 - 4.2e-20 71.6 0.2 3.6e-16 58.6 0.1 2.0 2 0 0 2 2 2 2 Myosin head (motor domain) 3HCDH_N PF02737.18 ETO31814.1 - 6.2e-60 202.2 0.3 7.9e-60 201.8 0.3 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain 3HCDH PF00725.22 ETO31814.1 - 3.4e-18 66.1 0.0 8.3e-18 64.8 0.0 1.7 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain NAD_binding_2 PF03446.15 ETO31814.1 - 0.00088 19.5 0.5 0.0025 18.0 0.2 2.0 2 1 0 2 2 2 1 NAD binding domain of 6-phosphogluconate dehydrogenase Phage_int_SAM_3 PF14659.6 ETO31814.1 - 0.028 14.7 0.7 1.3 9.3 0.1 2.5 1 1 1 2 2 2 0 Phage integrase, N-terminal SAM-like domain F420_oxidored PF03807.17 ETO31814.1 - 0.049 14.2 0.5 0.13 12.8 0.1 2.0 2 0 0 2 2 2 0 NADP oxidoreductase coenzyme F420-dependent NAD_binding_7 PF13241.6 ETO31814.1 - 0.11 12.9 0.1 0.36 11.3 0.0 1.8 2 0 0 2 2 2 0 Putative NAD(P)-binding Bac_rhamnosid_N PF08531.10 ETO31814.1 - 0.17 11.7 0.0 0.32 10.8 0.0 1.4 1 0 0 1 1 1 0 Alpha-L-rhamnosidase N-terminal domain DUF4191 PF13829.6 ETO31815.1 - 3.9 6.8 5.6 1.5 8.1 1.5 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF4191) CAP_C PF08603.11 ETO31816.1 - 6.9e-08 32.3 5.1 1.6e-07 31.0 5.1 1.6 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal TBCC PF07986.12 ETO31816.1 - 0.0028 17.4 4.6 0.0066 16.2 4.6 1.7 1 0 0 1 1 1 1 Tubulin binding cofactor C FGF-BP1 PF06473.12 ETO31816.1 - 0.02 14.8 7.0 0.031 14.1 7.0 1.3 1 0 0 1 1 1 0 FGF binding protein 1 (FGF-BP1) Zip PF02535.22 ETO31816.1 - 0.81 8.8 5.7 1.1 8.5 5.7 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Mitofilin PF09731.9 ETO31816.1 - 2.4 6.9 14.1 3.1 6.5 14.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Peptidase_M20 PF01546.28 ETO31817.1 - 4.4e-08 33.1 0.0 4.6e-08 33.0 0.0 1.0 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Sel1 PF08238.12 ETO31818.1 - 1.3e-20 73.4 26.4 2e-05 25.1 0.3 9.6 10 0 0 10 10 10 4 Sel1 repeat TPR_16 PF13432.6 ETO31818.1 - 0.018 15.7 4.3 0.42 11.3 0.7 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Proteasom_Rpn13 PF04683.13 ETO31818.1 - 0.026 15.1 0.4 0.079 13.5 0.2 2.0 2 0 0 2 2 2 0 Proteasome complex subunit Rpn13 ubiquitin receptor ShK PF01549.24 ETO31818.1 - 0.1 13.2 8.3 0.26 11.9 8.3 1.8 1 0 0 1 1 1 0 ShK domain-like CCDC24 PF15669.5 ETO31818.1 - 0.14 12.0 8.1 0.37 10.6 8.1 1.7 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 24 family DUF2072 PF09845.9 ETO31818.1 - 0.49 10.6 0.0 0.49 10.6 0.0 2.6 3 0 0 3 3 3 0 Zn-ribbon containing protein DUF4698 PF15769.5 ETO31818.1 - 1.8 7.5 9.5 3.8 6.5 9.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) Imm32 PF15566.6 ETO31820.1 - 0.0029 17.4 0.1 0.0052 16.6 0.1 1.3 1 0 0 1 1 1 1 Immunity protein 32 Herpes_UL92 PF03048.14 ETO31820.1 - 0.021 14.6 0.7 0.024 14.4 0.7 1.0 1 0 0 1 1 1 0 UL92 family IPPT PF01715.17 ETO31821.1 - 1.2e-43 149.6 3.4 8.8e-43 146.7 0.9 2.7 2 1 0 2 2 2 1 IPP transferase zf-C2H2_jaz PF12171.8 ETO31821.1 - 7.1e-05 23.0 3.1 0.00024 21.3 3.1 2.0 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2_2 PF12756.7 ETO31821.1 - 0.0048 17.2 2.0 0.014 15.7 2.0 1.9 1 0 0 1 1 1 1 C2H2 type zinc-finger (2 copies) RNA_helicase PF00910.22 ETO31821.1 - 0.014 15.8 4.5 13 6.2 0.2 4.1 4 0 0 4 4 4 0 RNA helicase AAA_33 PF13671.6 ETO31821.1 - 0.023 14.9 1.8 2.7 8.2 0.0 3.6 3 1 1 4 4 4 0 AAA domain AAA_18 PF13238.6 ETO31821.1 - 0.041 14.4 1.9 0.27 11.8 0.0 3.0 3 0 0 3 3 3 0 AAA domain PyocinActivator PF11112.8 ETO31821.1 - 0.062 13.4 0.4 0.18 11.9 0.0 2.0 2 0 0 2 2 2 0 Pyocin activator protein PrtN IncD PF17628.2 ETO31821.1 - 0.28 10.9 0.8 2.2 8.1 0.1 2.2 2 0 0 2 2 2 0 Inclusion membrane protein D zf-met PF12874.7 ETO31821.1 - 3.6 8.1 6.8 25 5.4 6.8 2.5 1 1 0 1 1 1 0 Zinc-finger of C2H2 type Hist_deacetyl PF00850.19 ETO31822.1 - 4.3e-47 161.1 5.8 2.1e-34 119.4 0.1 2.8 3 0 0 3 3 3 2 Histone deacetylase domain MFS_2 PF13347.6 ETO31822.1 - 0.013 14.1 0.3 0.022 13.3 0.3 1.3 1 0 0 1 1 1 0 MFS/sugar transport protein AgrB PF04647.15 ETO31822.1 - 0.23 10.8 4.2 0.075 12.3 0.3 2.0 2 0 0 2 2 2 0 Accessory gene regulator B FUSC_2 PF13515.6 ETO31822.1 - 1.1 9.3 3.6 0.4 10.8 0.2 1.9 2 0 0 2 2 2 0 Fusaric acid resistance protein-like DUF1104 PF06518.11 ETO31823.1 - 0.013 15.9 0.2 0.013 15.9 0.2 4.6 5 0 0 5 5 5 0 Protein of unknown function (DUF1104) SAWADEE PF16719.5 ETO31823.1 - 0.023 14.7 0.2 0.066 13.2 0.2 1.7 1 0 0 1 1 1 0 SAWADEE domain TetR_C_22 PF17928.1 ETO31823.1 - 0.028 14.7 1.5 6.3 7.2 0.1 2.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TetR_C_15 PF17918.1 ETO31823.1 - 0.3 11.8 7.2 58 4.5 0.0 4.3 4 1 0 4 4 4 0 Tetracyclin repressor-like, C-terminal domain Speriolin_C PF15059.6 ETO31823.1 - 0.55 10.3 9.7 0.88 9.7 1.5 3.8 4 0 0 4 4 4 0 Speriolin C-terminus RsbRD_N PF14361.6 ETO31823.1 - 0.58 10.9 4.0 1.8 9.3 0.0 3.7 3 0 0 3 3 3 0 RsbT co-antagonist protein rsbRD N-terminal domain DUF1043 PF06295.12 ETO31823.1 - 5.4 7.0 7.5 1 9.4 0.1 3.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1043) DUF87 PF01935.17 ETO31823.1 - 8.8 6.4 9.5 18 5.3 0.5 3.7 4 0 0 4 4 4 0 Helicase HerA, central domain 7TMR-HDED PF07697.11 ETO31823.1 - 9.1 6.3 12.7 1.6 8.8 0.1 3.9 4 0 0 4 4 4 0 7TM-HD extracellular SNF2_N PF00176.23 ETO31825.1 - 6.7e-47 159.9 3.4 6.7e-47 159.9 3.4 2.2 2 0 0 2 2 2 1 SNF2 family N-terminal domain Helicase_C PF00271.31 ETO31825.1 - 6e-19 68.4 0.0 2.3e-18 66.5 0.0 2.1 1 0 0 1 1 1 1 Helicase conserved C-terminal domain Chromo PF00385.24 ETO31825.1 - 8.8e-10 38.3 8.4 7.4e-05 22.6 3.6 4.0 2 1 0 2 2 2 2 Chromo (CHRromatin Organisation MOdifier) domain DEAD PF00270.29 ETO31825.1 - 5.3e-08 32.8 0.1 5.8e-07 29.4 0.1 2.5 1 1 0 1 1 1 1 DEAD/DEAH box helicase RNA_capsid PF03035.14 ETO31825.1 - 1 9.3 0.0 1 9.3 0.0 3.4 4 1 0 4 4 4 0 Calicivirus putative RNA polymerase/capsid protein Peptidase_C14 PF00656.22 ETO31826.1 - 5.5e-11 42.9 0.4 1.7e-10 41.3 0.4 1.8 1 0 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO31826.1 - 1.9e-05 24.5 1.5 0.64 10.1 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO31826.1 - 0.00011 21.7 1.3 0.005 16.4 0.1 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO31826.1 - 0.0012 18.7 6.3 0.0084 16.1 0.3 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO31826.1 - 0.0021 18.3 4.4 1.6 9.1 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO31826.1 - 0.0037 17.2 0.0 0.0037 17.2 0.0 2.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Sigma54_activ_2 PF14532.6 ETO31826.1 - 0.8 9.8 0.0 0.8 9.8 0.0 2.4 3 0 0 3 3 3 0 Sigma-54 interaction domain WD40 PF00400.32 ETO31827.1 - 5.9e-40 134.5 27.8 4e-07 30.6 0.2 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31827.1 - 1.7e-13 50.7 3.4 0.0057 16.9 0.0 5.3 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31827.1 - 2.4e-08 33.1 11.3 0.01 14.5 0.2 5.8 2 2 3 6 6 6 5 Nucleoporin Nup120/160 W_rich_C PF07483.11 ETO31827.1 - 0.74 10.0 5.7 16 5.7 0.1 3.1 3 1 0 3 3 3 0 Tryptophan-rich Synechocystis species C-terminal domain MmgE_PrpD PF03972.14 ETO31828.1 - 0.26 9.8 4.2 0.051 12.1 0.9 1.4 2 0 0 2 2 2 0 MmgE/PrpD family WD40 PF00400.32 ETO31829.1 - 4.4e-38 128.6 32.8 4.5e-07 30.5 0.6 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31829.1 - 9.5e-16 57.9 5.7 0.0043 17.3 0.1 5.6 5 1 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31829.1 - 9.2e-13 47.7 12.0 0.007 15.1 0.2 5.8 1 1 5 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31829.1 - 1e-05 25.1 7.6 0.0079 15.6 0.3 4.1 2 2 1 3 3 3 3 WD40-like domain Nucleoporin_N PF08801.11 ETO31829.1 - 0.00022 20.1 11.0 0.62 8.7 0.1 5.1 2 2 2 4 4 4 2 Nup133 N terminal like Ac76 PF05814.11 ETO31829.1 - 0.17 11.9 3.4 0.41 10.7 3.4 1.6 1 0 0 1 1 1 0 Orf76 (Ac76) WD40 PF00400.32 ETO31830.1 - 3e-39 132.3 29.9 5e-07 30.3 0.3 8.2 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31830.1 - 6e-11 42.5 3.3 0.21 11.9 0.0 5.4 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31830.1 - 5.9e-09 35.1 6.1 0.11 11.1 0.0 4.9 2 2 3 5 5 5 4 Nucleoporin Nup120/160 Peptidase_C6 PF00851.18 ETO31830.1 - 0.032 13.2 2.5 0.035 13.0 1.1 1.8 2 0 0 2 2 2 0 Helper component proteinase DIM1 PF02966.16 ETO31830.1 - 0.12 12.1 0.8 0.3 10.9 0.3 1.9 2 0 0 2 2 2 0 Mitosis protein DIM1 DUF658 PF04936.12 ETO31830.1 - 0.31 10.8 0.8 0.74 9.5 0.2 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF658) Secretin_N_2 PF07655.13 ETO31831.1 - 0.079 13.5 6.1 0.19 12.3 6.1 1.7 1 0 0 1 1 1 0 Secretin N-terminal domain Striatin PF08232.12 ETO31831.1 - 0.096 13.3 1.6 0.41 11.2 1.0 2.1 2 0 0 2 2 2 0 Striatin family Porph_ging PF09697.10 ETO31831.1 - 0.11 13.0 0.6 2.4 8.8 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (Porph_ging) Cwf_Cwc_15 PF04889.12 ETO31831.1 - 2.2 7.9 20.3 0.04 13.6 8.5 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein TFB6 PF17110.5 ETO31831.1 - 3.1 7.5 12.6 1.3 8.7 3.7 2.4 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH CAP_GLY PF01302.25 ETO31832.1 - 7.7e-08 32.2 1.4 1.6e-07 31.2 0.1 2.1 2 1 0 2 2 2 1 CAP-Gly domain DUF4094 PF13334.6 ETO31833.1 - 0.21 12.0 1.6 0.33 11.4 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) MPM1 PF17234.2 ETO31836.1 - 6.9 6.9 18.7 46 4.2 0.0 2.9 2 0 0 2 2 2 0 Mitochondrial peculiar membrane protein 1 Secretin_N_2 PF07655.13 ETO31837.1 - 0.24 12.0 11.1 0.87 10.2 11.1 2.0 1 0 0 1 1 1 0 Secretin N-terminal domain Bud13 PF09736.9 ETO31838.1 - 8.2e-26 91.1 36.3 7.1e-17 62.1 11.4 5.6 2 2 2 4 4 4 2 Pre-mRNA-splicing factor of RES complex ABC2_membrane_3 PF12698.7 ETO31839.1 - 0.0049 16.0 1.0 0.0079 15.3 1.0 1.4 1 0 0 1 1 1 1 ABC-2 family transporter protein LAP1C PF05609.12 ETO31839.1 - 0.052 12.6 17.1 0.012 14.8 13.2 1.8 2 0 0 2 2 2 0 Lamina-associated polypeptide 1C (LAP1C) DUF3439 PF11921.8 ETO31839.1 - 0.33 10.9 4.8 0.28 11.2 2.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) PDEase_I PF00233.19 ETO31840.1 - 2.7e-31 109.1 0.0 3.5e-31 108.8 0.0 1.0 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase AWS PF17907.1 ETO31842.1 - 0.015 15.3 0.5 0.032 14.2 0.5 1.5 1 0 0 1 1 1 0 AWS domain Ion_trans PF00520.31 ETO31843.1 - 2.1e-10 40.3 29.8 2.1e-10 40.3 29.8 2.2 2 0 0 2 2 2 1 Ion transport protein BatD PF13584.6 ETO31844.1 - 0.0039 16.1 0.3 0.0086 14.9 0.3 1.5 1 1 0 1 1 1 1 Oxygen tolerance DUF1673 PF07895.11 ETO31844.1 - 0.0051 16.6 8.4 0.0066 16.2 8.4 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1673) Na_trans_assoc PF06512.13 ETO31844.1 - 1 9.6 6.2 3.5 7.9 1.0 2.0 2 0 0 2 2 2 0 Sodium ion transport-associated PP2C PF00481.21 ETO31845.1 - 2e-16 60.4 0.0 4.4e-13 49.5 0.0 2.4 2 1 0 2 2 2 2 Protein phosphatase 2C zf-TRAF_2 PF15965.5 ETO31846.1 - 9.5 6.8 11.9 5.6 7.5 7.6 2.4 2 1 1 3 3 3 0 TRAF-like zinc-finger Actin PF00022.19 ETO31847.1 - 2.1e-19 69.5 0.0 2.9e-19 69.0 0.0 1.2 1 0 0 1 1 1 1 Actin Actin PF00022.19 ETO31848.1 - 1.5e-47 162.2 0.0 2.1e-47 161.6 0.0 1.2 1 0 0 1 1 1 1 Actin MreB_Mbl PF06723.13 ETO31848.1 - 0.12 11.2 0.0 0.13 11.0 0.0 1.3 1 0 0 1 1 1 0 MreB/Mbl protein Alpha_adaptin_C PF02296.16 ETO31849.1 - 6.7e-15 55.3 0.0 1.8e-14 53.9 0.0 1.8 1 0 0 1 1 1 1 Alpha adaptin AP2, C-terminal domain Alpha_adaptinC2 PF02883.20 ETO31849.1 - 5e-13 49.3 2.0 5e-13 49.3 2.0 2.2 4 0 0 4 4 4 1 Adaptin C-terminal domain B2-adapt-app_C PF09066.10 ETO31849.1 - 0.00028 20.9 0.1 0.0025 17.9 0.0 2.5 2 1 0 2 2 2 1 Beta2-adaptin appendage, C-terminal sub-domain Coatomer_g_Cpla PF16381.5 ETO31849.1 - 0.00056 20.0 0.0 0.001 19.2 0.0 1.4 1 0 0 1 1 1 1 Coatomer subunit gamma-1 C-terminal appendage platform Coatomer_b_Cpla PF14806.6 ETO31849.1 - 0.0016 18.4 0.0 0.0059 16.6 0.0 1.9 2 0 0 2 2 2 1 Coatomer beta subunit appendage platform AP4E_app_platf PF14807.6 ETO31849.1 - 0.0016 18.7 0.0 0.0072 16.7 0.0 2.1 2 1 0 2 2 2 1 Adaptin AP4 complex epsilon appendage platform FixG_C PF11614.8 ETO31849.1 - 0.064 13.5 1.3 0.97 9.7 0.1 2.5 2 0 0 2 2 2 0 IG-like fold at C-terminal of FixG, putative oxidoreductase DUF167 PF02594.16 ETO31849.1 - 0.1 12.7 0.1 0.35 11.0 0.1 1.9 1 0 0 1 1 1 0 Uncharacterised ACR, YggU family COG1872 DUF3447 PF11929.8 ETO31850.1 - 0.00057 19.8 0.7 0.0026 17.7 0.0 2.4 2 0 0 2 2 2 1 Domain of unknown function (DUF3447) Rad50_zn_hook PF04423.14 ETO31850.1 - 0.023 14.5 0.5 0.096 12.5 0.5 2.1 1 0 0 1 1 1 0 Rad50 zinc hook motif TPR_12 PF13424.6 ETO31851.1 - 7.5e-24 83.8 0.1 1.9e-10 40.9 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO31851.1 - 2e-17 62.4 0.0 0.0044 16.9 0.0 4.4 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31851.1 - 8.4e-16 56.7 9.0 0.00051 19.9 0.1 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31851.1 - 1.5e-14 53.1 19.7 0.00016 21.4 2.3 4.9 4 1 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31851.1 - 1.8e-13 49.5 1.1 7e-07 28.8 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31851.1 - 3.6e-13 48.6 18.0 3.8e-06 26.7 0.2 4.7 5 0 0 5 5 4 3 Tetratricopeptide repeat MIT PF04212.18 ETO31851.1 - 4.6e-05 23.4 9.0 1.5 8.9 0.0 5.1 5 0 0 5 5 5 2 MIT (microtubule interacting and transport) domain TPR_6 PF13174.6 ETO31851.1 - 0.00064 20.2 3.0 0.6 10.9 0.0 3.6 4 0 0 4 4 3 1 Tetratricopeptide repeat SNAP PF14938.6 ETO31851.1 - 0.00087 18.8 0.1 0.0018 17.8 0.1 1.6 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO31851.1 - 0.0011 19.2 2.2 0.41 11.1 0.0 4.1 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31851.1 - 0.0052 17.5 0.0 5.8 8.0 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat CSF-1 PF05337.11 ETO31851.1 - 0.013 15.6 0.1 0.051 13.7 0.1 2.1 1 0 0 1 1 1 0 Macrophage colony stimulating factor-1 (CSF-1) TPR_11 PF13414.6 ETO31851.1 - 0.071 12.8 0.6 0.071 12.8 0.6 5.0 5 2 2 7 7 7 0 TPR repeat TPR_16 PF13432.6 ETO31851.1 - 0.11 13.2 0.0 37 5.1 0.0 3.4 2 2 0 2 2 2 0 Tetratricopeptide repeat DUF4337 PF14235.6 ETO31851.1 - 0.17 12.0 4.1 0.065 13.3 1.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4337) Sel1 PF08238.12 ETO31851.1 - 0.22 12.3 3.5 41 5.1 0.1 4.2 4 0 0 4 4 4 0 Sel1 repeat DUF5113 PF17140.4 ETO31851.1 - 0.35 10.7 4.6 52 3.6 0.1 3.8 2 1 1 4 4 4 0 Domain of unknown function (DUF5113) Rhomboid PF01694.22 ETO31852.1 - 6.2e-24 84.7 10.5 6.2e-24 84.7 10.5 1.4 2 0 0 2 2 2 1 Rhomboid family DUF1751 PF08551.10 ETO31852.1 - 3.7e-05 24.2 0.6 3.7e-05 24.2 0.6 2.1 3 0 0 3 3 3 1 Eukaryotic integral membrane protein (DUF1751) HPP PF04982.13 ETO31852.1 - 1.2 9.3 5.9 11 6.2 0.5 2.7 3 0 0 3 3 3 0 HPP family PCNA_C PF02747.15 ETO31853.1 - 4.2e-48 162.7 0.0 2e-47 160.6 0.0 1.8 2 0 0 2 2 2 1 Proliferating cell nuclear antigen, C-terminal domain PCNA_N PF00705.18 ETO31853.1 - 8.9e-45 151.5 1.9 1.4e-44 150.9 1.9 1.3 1 0 0 1 1 1 1 Proliferating cell nuclear antigen, N-terminal domain Rad1 PF02144.16 ETO31853.1 - 4.6e-07 29.2 0.2 6.7e-06 25.4 0.2 2.4 1 1 0 1 1 1 1 Repair protein Rad1/Rec1/Rad17 Rad9 PF04139.13 ETO31853.1 - 0.00073 19.1 0.1 0.00087 18.8 0.1 1.2 1 0 0 1 1 1 1 Rad9 Hus1 PF04005.12 ETO31853.1 - 0.055 12.6 0.0 7.3 5.6 0.0 2.2 2 0 0 2 2 2 0 Hus1-like protein UPF0715 PF17094.5 ETO31854.1 - 0.0086 16.6 0.2 0.018 15.6 0.2 1.5 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0715) MBOAT PF03062.19 ETO31854.1 - 0.011 15.1 0.1 0.013 14.9 0.1 1.3 1 0 0 1 1 1 0 MBOAT, membrane-bound O-acyltransferase family PT PF04886.12 ETO31855.1 - 1e-10 40.9 76.3 1.2e-05 24.7 21.2 5.7 4 2 1 5 5 5 3 PT repeat LTD PF00932.19 ETO31855.1 - 0.00042 20.7 0.6 0.00042 20.7 0.6 2.4 2 0 0 2 2 2 1 Lamin Tail Domain Glycoprotein_G PF00802.19 ETO31855.1 - 0.14 11.5 38.8 0.17 11.2 9.5 2.9 3 0 0 3 3 3 0 Pneumovirus attachment glycoprotein G DUF4381 PF14316.6 ETO31855.1 - 0.2 11.9 0.1 0.4 10.9 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4381) Pkinase PF00069.25 ETO31856.1 - 6.3e-62 209.3 0.0 1e-60 205.4 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31856.1 - 1.6e-22 80.1 0.0 2.4e-22 79.5 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Reprolysin_5 PF13688.6 ETO31857.1 - 2.3e-09 37.7 0.3 6.1e-09 36.3 0.3 1.7 1 0 0 1 1 1 1 Metallo-peptidase family M12 Reprolysin_2 PF13574.6 ETO31857.1 - 4.6e-07 29.9 0.3 1e-06 28.8 0.3 1.6 1 0 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Hemopexin PF00045.19 ETO31857.1 - 6.6e-06 26.0 5.2 0.17 11.9 0.0 4.5 4 0 0 4 4 4 2 Hemopexin Reprolysin_4 PF13583.6 ETO31857.1 - 5.9e-05 22.8 3.8 0.00076 19.2 3.8 2.6 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like Reprolysin_3 PF13582.6 ETO31857.1 - 0.00077 20.0 0.2 0.0028 18.2 0.2 2.0 1 1 0 1 1 1 1 Metallo-peptidase family M12B Reprolysin-like DUF4668 PF15701.5 ETO31857.1 - 4.1 7.2 9.5 1.3 8.9 1.9 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4668) HTH_48 PF17906.1 ETO31858.1 - 0.045 13.9 0.1 0.12 12.5 0.1 1.7 1 0 0 1 1 1 0 HTH domain in Mos1 transposase Menin PF05053.13 ETO31859.1 - 0.97 7.7 5.6 1.3 7.3 5.6 1.1 1 0 0 1 1 1 0 Menin Ion_trans_2 PF07885.16 ETO31860.1 - 3.1e-11 43.1 16.5 1.8e-10 40.6 1.0 3.7 3 1 1 4 4 4 2 Ion channel Cation_ATPase_C PF00689.21 ETO31860.1 - 0.02 14.6 6.4 1.2 8.8 6.4 2.2 1 1 0 1 1 1 0 Cation transporting ATPase, C-terminus FAM176 PF14851.6 ETO31860.1 - 0.089 12.5 0.0 0.18 11.5 0.0 1.4 1 0 0 1 1 1 0 FAM176 family FA_desaturase PF00487.24 ETO31860.1 - 0.29 10.9 3.7 0.18 11.6 1.1 1.8 1 1 1 2 2 2 0 Fatty acid desaturase LapA_dom PF06305.11 ETO31860.1 - 3.1 7.7 8.4 12 5.8 0.0 3.4 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Exo_endo_phos PF03372.23 ETO31861.1 - 0.013 15.1 0.0 0.014 14.9 0.0 1.2 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos PF03372.23 ETO31862.1 - 0.028 13.9 0.0 0.057 12.9 0.0 1.5 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Phage_Mu_Gam PF07352.12 ETO31863.1 - 0.00066 19.6 5.0 0.00066 19.6 5.0 2.6 1 1 0 2 2 2 1 Bacteriophage Mu Gam like protein HIP1_clath_bdg PF16515.5 ETO31863.1 - 0.00076 20.1 9.1 0.00076 20.1 9.1 2.6 3 0 0 3 3 3 1 Clathrin-binding domain of Huntingtin-interacting protein 1 OmpH PF03938.14 ETO31863.1 - 0.013 15.8 22.8 0.029 14.7 7.8 2.3 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Mononeg_mRNAcap PF14318.6 ETO31863.1 - 0.027 13.7 1.5 0.042 13.1 1.5 1.3 1 0 0 1 1 1 0 Mononegavirales mRNA-capping region V DUF4200 PF13863.6 ETO31863.1 - 1 9.8 28.9 3.2 8.2 3.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4200) TMF_TATA_bd PF12325.8 ETO31863.1 - 1.7 8.9 20.3 4.9 7.4 8.1 3.4 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding ApoO PF09769.9 ETO31863.1 - 2.3 8.2 4.8 3.1 7.8 0.5 2.4 2 0 0 2 2 2 0 Apolipoprotein O DUF4407 PF14362.6 ETO31863.1 - 2.7 7.3 13.2 4.1 6.7 13.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) HECT PF00632.25 ETO31864.1 - 5.4e-67 226.4 0.0 3.4e-65 220.5 0.0 2.3 1 1 0 2 2 2 2 HECT-domain (ubiquitin-transferase) Glyco_transf_92 PF01697.27 ETO31868.1 - 4.3e-06 26.6 11.6 5e-05 23.1 11.6 2.4 1 1 0 1 1 1 1 Glycosyltransferase family 92 Glyco_tranf_2_4 PF13704.6 ETO31868.1 - 0.00021 21.7 5.1 0.00021 21.7 5.1 2.3 2 0 0 2 2 2 1 Glycosyl transferase family 2 APG6_N PF17675.1 ETO31869.1 - 0.32 11.5 10.1 0.63 10.6 10.1 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region KELK PF15796.5 ETO31869.1 - 0.83 10.2 7.0 2.7 8.5 7.0 1.9 1 1 0 1 1 1 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase WW PF00397.26 ETO31871.1 - 4.5e-26 90.6 18.0 6e-07 29.4 1.5 4.4 4 0 0 4 4 4 4 WW domain DUF4585 PF15232.6 ETO31871.1 - 0.77 9.9 5.5 53 4.0 1.7 4.1 3 1 0 3 3 3 0 Domain of unknown function (DUF4585) SOG2 PF10428.9 ETO31871.1 - 1.4 8.0 7.1 1.7 7.8 7.1 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ndc1_Nup PF09531.10 ETO31871.1 - 3.1 6.4 5.2 3 6.4 5.2 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup MAP1B_neuraxin PF00414.17 ETO31871.1 - 3.3 7.4 7.8 6.2 6.5 1.1 3.2 3 0 0 3 3 3 0 Neuraxin and MAP1B repeat Sulfotransfer_1 PF00685.27 ETO31872.1 - 0.00035 20.1 4.0 0.0011 18.5 3.9 1.9 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_2 PF03567.14 ETO31872.1 - 0.0033 17.4 1.1 0.0078 16.1 0.9 1.9 2 1 0 2 2 2 1 Sulfotransferase family Sulfotransfer_3 PF13469.6 ETO31872.1 - 0.034 14.5 0.2 0.34 11.2 0.1 2.6 2 1 0 2 2 2 0 Sulfotransferase family DAO PF01266.24 ETO31873.1 - 1.7e-11 44.3 0.4 1.5e-10 41.2 0.4 2.1 1 1 0 1 1 1 1 FAD dependent oxidoreductase NAD_binding_8 PF13450.6 ETO31873.1 - 1.4e-10 41.3 0.2 3.8e-10 39.9 0.2 1.8 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Amino_oxidase PF01593.24 ETO31873.1 - 2.2e-09 37.2 0.1 3.3e-08 33.2 0.0 2.7 2 1 0 2 2 2 1 Flavin containing amine oxidoreductase FAD_oxidored PF12831.7 ETO31873.1 - 1e-06 28.4 0.0 2.4e-06 27.2 0.0 1.7 1 0 0 1 1 1 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETO31873.1 - 1.3e-06 27.8 0.1 2.5e-06 26.9 0.1 1.4 1 0 0 1 1 1 1 Thi4 family FAD_binding_2 PF00890.24 ETO31873.1 - 1.2e-05 24.7 4.7 7.5e-05 22.0 0.8 2.7 3 0 0 3 3 3 1 FAD binding domain Pyr_redox PF00070.27 ETO31873.1 - 1.2e-05 25.8 0.5 8.1e-05 23.1 0.2 2.2 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_2 PF07992.14 ETO31873.1 - 1.7e-05 24.2 0.1 0.00018 20.8 0.0 2.4 3 0 0 3 3 3 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETO31873.1 - 6.9e-05 22.1 0.1 0.0015 17.7 0.1 2.1 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ETO31873.1 - 0.00014 21.2 0.2 0.00028 20.3 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ETO31873.1 - 0.00076 18.3 0.2 0.0013 17.6 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox_3 PF13738.6 ETO31873.1 - 0.015 14.6 0.6 0.026 13.8 0.6 1.3 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Trp_halogenase PF04820.14 ETO31873.1 - 0.015 14.1 0.0 0.023 13.6 0.0 1.2 1 0 0 1 1 1 0 Tryptophan halogenase 2-Hacid_dh_C PF02826.19 ETO31873.1 - 0.076 12.4 0.1 2.9 7.2 0.0 2.2 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain MCRA PF06100.11 ETO31873.1 - 0.15 10.8 0.0 0.32 9.7 0.0 1.5 1 0 0 1 1 1 0 MCRA family Lycopene_cycl PF05834.12 ETO31873.1 - 0.16 11.0 0.5 0.3 10.1 0.5 1.4 1 0 0 1 1 1 0 Lycopene cyclase protein Exo_endo_phos PF03372.23 ETO31874.1 - 0.0089 15.6 0.0 0.012 15.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family MCM PF00493.23 ETO31875.1 - 5.5e-98 326.5 0.0 8.2e-98 326.0 0.0 1.3 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETO31875.1 - 7.6e-36 122.7 0.1 1.8e-35 121.5 0.1 1.6 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETO31875.1 - 2.6e-27 95.1 0.3 6.9e-26 90.5 0.1 2.6 2 0 0 2 2 2 1 MCM AAA-lid domain MCM_N PF14551.6 ETO31875.1 - 7.1e-11 42.6 2.5 5e-07 30.3 0.2 3.2 3 0 0 3 3 3 2 MCM N-terminal domain Mg_chelatase PF01078.21 ETO31875.1 - 6e-08 32.3 0.0 4.6e-07 29.4 0.0 2.3 1 1 0 2 2 2 1 Magnesium chelatase, subunit ChlI MCM2_N PF12619.8 ETO31875.1 - 4.6e-05 23.7 2.5 4.6e-05 23.7 2.5 2.9 4 0 0 4 4 4 1 Mini-chromosome maintenance protein 2 AAA_5 PF07728.14 ETO31875.1 - 5.4e-05 23.2 0.0 0.00012 22.1 0.0 1.7 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_3 PF07726.11 ETO31875.1 - 0.00054 19.8 0.0 0.0024 17.8 0.0 2.1 2 1 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETO31875.1 - 0.0058 16.3 0.1 1.5 8.5 0.0 2.3 2 0 0 2 2 2 2 Sigma-54 interaction domain AAA_lid_2 PF17863.1 ETO31875.1 - 0.11 12.4 0.0 0.34 10.8 0.0 1.8 1 0 0 1 1 1 0 AAA lid domain Zn-ribbon_8 PF09723.10 ETO31875.1 - 0.12 12.5 0.6 0.33 11.1 0.6 1.7 1 0 0 1 1 1 0 Zinc ribbon domain TPR_1 PF00515.28 ETO31876.1 - 0.028 14.2 0.1 0.32 10.9 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO31876.1 - 0.058 13.7 0.0 0.085 13.2 0.0 1.2 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31876.1 - 0.063 13.5 0.2 0.16 12.2 0.1 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat PUB PF09409.10 ETO31877.1 - 0.0013 18.6 1.2 0.0037 17.2 0.2 2.3 2 0 0 2 2 2 1 PUB domain ApoC-I PF04691.12 ETO31877.1 - 0.031 14.2 0.5 0.095 12.6 0.5 1.8 1 0 0 1 1 1 0 Apolipoprotein C-I (ApoC-1) SAP PF02037.27 ETO31878.1 - 0.094 12.5 0.6 0.15 11.9 0.6 1.3 1 0 0 1 1 1 0 SAP domain Sulfotransfer_1 PF00685.27 ETO31880.1 - 1e-34 120.2 4.1 6.7e-18 65.1 0.3 2.3 2 0 0 2 2 2 2 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO31880.1 - 0.0012 19.3 0.0 1.2 9.5 0.0 3.2 2 1 0 2 2 2 2 Sulfotransferase family BRD4_CDT PF17105.5 ETO31881.1 - 0.75 9.4 5.6 1.9 8.1 5.6 1.7 1 0 0 1 1 1 0 C-terminal domain of bromodomain protein 4 Solute_trans_a PF03619.16 ETO31882.1 - 8.2e-68 228.8 19.4 1e-67 228.4 19.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha NESP55 PF06390.12 ETO31882.1 - 0.6 9.7 6.5 0.89 9.1 6.5 1.2 1 0 0 1 1 1 0 Neuroendocrine-specific golgi protein P55 (NESP55) Peptidase_C25_C PF03785.14 ETO31883.1 - 0.21 11.5 2.0 0.21 11.4 0.4 1.9 2 0 0 2 2 2 0 Peptidase family C25, C terminal ig-like domain DUF3817 PF12823.7 ETO31883.1 - 0.23 12.3 4.7 0.9 10.4 4.7 2.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3817) SH3_1 PF00018.28 ETO31886.1 - 2.9e-15 55.6 0.3 5.1e-15 54.8 0.3 1.4 1 0 0 1 1 1 1 SH3 domain VHP PF02209.19 ETO31886.1 - 2.1e-14 53.3 1.8 4.2e-14 52.3 1.8 1.6 1 0 0 1 1 1 1 Villin headpiece domain SH3_9 PF14604.6 ETO31886.1 - 2.8e-11 43.1 0.0 6.5e-11 41.9 0.0 1.6 2 0 0 2 2 2 1 Variant SH3 domain SH3_2 PF07653.17 ETO31886.1 - 2.9e-11 42.9 0.0 5.5e-11 42.0 0.0 1.5 1 0 0 1 1 1 1 Variant SH3 domain FerI PF08151.12 ETO31886.1 - 2.7 8.2 4.0 3.1 8.0 0.0 2.9 3 1 0 3 3 3 0 FerI (NUC094) domain RhoGEF PF00621.20 ETO31887.1 - 4.1e-12 46.7 2.8 5.3e-12 46.3 2.8 1.1 1 0 0 1 1 1 1 RhoGEF domain EpsG PF14897.6 ETO31887.1 - 0.0018 17.6 5.9 0.0021 17.4 5.9 1.1 1 0 0 1 1 1 1 EpsG family SpoIISA_toxin PF14171.6 ETO31887.1 - 0.12 12.0 6.9 0.16 11.6 0.1 2.1 2 0 0 2 2 2 0 Toxin SpoIISA, type II toxin-antitoxin system UPF0160 PF03690.13 ETO31888.1 - 9.8e-32 110.8 0.0 1.1e-31 110.7 0.0 1.0 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0160) WD40 PF00400.32 ETO31889.1 - 5.9e-61 201.0 15.4 2.3e-10 40.9 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31889.1 - 5.2e-21 74.7 3.6 6.6e-06 26.3 0.2 5.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31889.1 - 1.2e-09 37.6 1.0 0.012 14.6 0.2 5.3 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO31889.1 - 8e-09 35.2 1.8 0.0036 16.7 0.0 3.3 1 1 3 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO31889.1 - 4.1e-08 33.3 0.3 1.1e-05 25.5 0.0 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO31889.1 - 1.9e-07 30.0 1.9 0.00058 18.5 0.0 3.1 1 1 2 3 3 3 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO31889.1 - 5.9e-06 25.3 5.5 0.06 12.1 0.0 3.4 1 1 2 3 3 3 3 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO31889.1 - 0.00036 19.7 1.1 0.003 16.7 0.4 2.0 1 1 1 2 2 2 1 Coatomer WD associated region DUF5570 PF17731.1 ETO31889.1 - 0.0014 18.8 1.4 3.8 7.6 0.1 3.9 2 1 3 5 5 5 2 Family of unknown function (DUF5570) DPPIV_N PF00930.21 ETO31889.1 - 0.0035 16.1 0.0 10 4.8 0.0 3.8 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9_N PF02897.15 ETO31889.1 - 0.0087 14.9 0.7 8.7 5.0 0.0 3.3 2 1 1 3 3 3 2 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF5497 PF17601.2 ETO31889.1 - 0.066 13.5 0.1 0.77 10.1 0.0 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5497) B_lectin PF01453.24 ETO31889.1 - 0.1 13.1 1.6 0.36 11.4 0.2 2.5 3 1 0 3 3 2 0 D-mannose binding lectin PD40 PF07676.12 ETO31889.1 - 0.11 12.4 0.6 32 4.6 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat MIase PF02426.16 ETO31889.1 - 0.17 12.1 0.3 52 4.1 0.0 3.8 5 0 0 5 5 4 0 Muconolactone delta-isomerase Proteasome_A_N PF10584.9 ETO31889.1 - 0.23 11.2 0.9 19 5.0 0.0 3.5 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF1751 PF08551.10 ETO31890.1 - 0.96 10.1 14.0 0.08 13.5 5.0 3.1 3 1 0 3 3 3 0 Eukaryotic integral membrane protein (DUF1751) eIF-3c_N PF05470.12 ETO31891.1 - 2e-45 155.2 2.8 2e-45 155.2 2.8 1.3 2 0 0 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus PCI PF01399.27 ETO31891.1 - 2.7e-07 31.0 0.1 7.4e-07 29.6 0.1 1.7 1 0 0 1 1 1 1 PCI domain ANAPC3 PF12895.7 ETO31891.1 - 0.00042 20.5 0.1 0.19 12.0 0.1 2.6 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 Staphostatin_A PF09022.10 ETO31891.1 - 0.018 14.9 0.1 0.88 9.5 0.0 2.9 3 0 0 3 3 3 0 Staphostatin A Solute_trans_a PF03619.16 ETO31892.1 - 5.7e-44 150.6 6.4 7.3e-44 150.3 6.4 1.1 1 0 0 1 1 1 1 Organic solute transporter Ostalpha DUF3123 PF11321.8 ETO31894.1 - 0.035 14.8 5.5 0.56 10.9 1.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) SOG2 PF10428.9 ETO31894.1 - 9.3 5.3 15.3 11 5.0 15.3 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SieB PF14163.6 ETO31895.1 - 0.46 10.0 5.2 0.31 10.5 2.5 2.2 2 1 1 3 3 3 0 Super-infection exclusion protein B SOBP PF15279.6 ETO31895.1 - 2.1 8.9 19.4 2.8 8.5 19.4 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein DUF4386 PF14329.6 ETO31897.1 - 0.00082 19.3 1.5 0.00098 19.0 1.5 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4386) Atthog PF18800.1 ETO31897.1 - 0.022 14.7 3.5 0.025 14.5 3.5 1.1 1 0 0 1 1 1 0 Attenuator of Hedgehog DUF3377 PF11857.8 ETO31897.1 - 0.24 11.3 2.2 2.8 7.9 0.6 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3377) WD40 PF00400.32 ETO31901.1 - 1.2e-07 32.2 0.3 2.5e-05 24.9 0.2 3.2 2 2 0 2 2 2 1 WD domain, G-beta repeat CLIP1_ZNF PF16641.5 ETO31901.1 - 0.038 13.9 3.8 0.038 13.9 3.8 2.2 2 0 0 2 2 2 0 CLIP1 zinc knuckle BBS2_Mid PF14783.6 ETO31901.1 - 0.077 13.0 0.1 13 5.9 0.1 2.9 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region Peptidase_C14 PF00656.22 ETO31902.1 - 2.7e-06 27.5 0.5 8.3e-06 25.9 0.5 1.8 1 1 0 1 1 1 1 Caspase domain PrpR_N PF06506.11 ETO31903.1 - 0.069 12.7 0.2 0.5 9.9 0.0 2.2 2 0 0 2 2 2 0 Propionate catabolism activator GNVR PF13807.6 ETO31903.1 - 0.2 11.6 0.7 0.67 9.9 0.0 2.2 2 0 0 2 2 2 0 G-rich domain on putative tyrosine kinase Spherulin4 PF12138.8 ETO31903.1 - 2.4 7.8 9.4 0.35 10.5 2.6 2.2 2 0 0 2 2 2 0 Spherulation-specific family 4 FKBP_C PF00254.28 ETO31904.1 - 8e-26 90.2 0.1 1.4e-22 79.8 0.1 2.2 2 0 0 2 2 2 2 FKBP-type peptidyl-prolyl cis-trans isomerase Amidase_2 PF01510.25 ETO31905.1 - 0.078 13.4 0.3 0.81 10.2 0.0 2.5 2 2 0 2 2 2 0 N-acetylmuramoyl-L-alanine amidase BSP_II PF05432.11 ETO31906.1 - 1.6 8.3 28.3 2.1 8.0 28.3 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) DUF4228 PF14009.6 ETO31906.1 - 7.4 6.9 12.8 1.7 9.0 0.7 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4228) WD40 PF00400.32 ETO31907.1 - 8.4e-60 197.3 26.4 5.3e-10 39.7 1.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31907.1 - 8.4e-22 77.3 6.3 0.0035 17.6 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31907.1 - 1.1e-11 44.2 6.8 0.054 12.4 0.0 6.0 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO31907.1 - 5.9e-11 42.2 1.3 0.015 14.7 0.1 3.7 2 1 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO31907.1 - 1.8e-07 30.2 10.4 1.1 7.8 0.1 5.9 1 1 5 6 6 6 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO31907.1 - 4.1e-05 22.5 11.7 0.13 10.9 0.2 4.6 1 1 3 4 4 4 3 Nup133 N terminal like DUF5046 PF16465.5 ETO31907.1 - 0.0024 17.4 0.0 0.0074 15.8 0.0 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF5046) Cytochrom_D1 PF02239.16 ETO31907.1 - 0.013 14.0 5.5 0.33 9.4 0.1 2.9 1 1 2 3 3 3 0 Cytochrome D1 heme domain Peptidase_S9_N PF02897.15 ETO31907.1 - 0.38 9.5 2.9 1.8 7.3 0.1 3.0 2 2 1 4 4 4 0 Prolyl oligopeptidase, N-terminal beta-propeller domain DUF5570 PF17731.1 ETO31907.1 - 2.2 8.4 9.1 8.9 6.4 0.1 4.1 1 1 4 5 5 5 0 Family of unknown function (DUF5570) TPR_12 PF13424.6 ETO31908.1 - 4.1e-37 126.3 10.1 3.7e-11 43.2 0.0 4.1 2 2 3 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO31908.1 - 3e-18 65.1 5.0 2.6e-05 23.9 0.1 6.3 7 0 0 7 7 7 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31908.1 - 7.1e-18 63.2 9.9 1.1e-06 28.3 0.1 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31908.1 - 1.3e-16 59.6 19.6 3.9e-09 35.9 0.5 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31908.1 - 1.9e-14 52.6 23.3 3.5e-07 29.9 1.3 6.5 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31908.1 - 4.9e-12 45.0 3.2 8.3e-05 22.3 0.0 4.8 5 0 0 5 5 5 3 Tetratricopeptide repeat DUF2225 PF09986.9 ETO31908.1 - 0.00026 20.8 3.8 0.012 15.4 0.3 2.7 1 1 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_6 PF13174.6 ETO31908.1 - 0.00095 19.7 1.3 1.5 9.6 0.1 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO31908.1 - 0.0015 19.2 0.0 8.9 7.4 0.0 3.7 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31908.1 - 0.0044 16.7 1.0 0.0044 16.7 1.0 5.3 5 2 1 6 6 6 1 TPR repeat MIT PF04212.18 ETO31908.1 - 0.019 15.1 8.0 31 4.7 0.0 5.2 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO31908.1 - 0.054 13.9 8.0 0.72 10.4 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat NSF PF02071.20 ETO31908.1 - 2.9 9.0 8.4 26 6.2 1.8 4.6 4 0 0 4 4 3 0 Aromatic-di-Alanine (AdAR) repeat SAM_2 PF07647.17 ETO31909.1 - 0.00014 21.9 0.0 0.00028 20.9 0.0 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_3 PF18016.1 ETO31909.1 - 0.011 15.6 0.0 0.018 14.8 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) Mito_carr PF00153.27 ETO31910.1 - 3.3e-32 110.3 0.1 1.4e-16 60.2 0.0 2.1 2 0 0 2 2 2 2 Mitochondrial carrier protein TauE PF01925.19 ETO31910.1 - 0.19 11.3 1.4 0.34 10.5 0.3 1.7 1 1 0 1 1 1 0 Sulfite exporter TauE/SafE Peptidase_C14 PF00656.22 ETO31911.1 - 5.4e-05 23.3 0.1 6.5e-05 23.0 0.1 1.2 1 0 0 1 1 1 1 Caspase domain NTF-like PF14540.6 ETO31911.1 - 0.059 13.1 0.2 0.08 12.7 0.2 1.1 1 0 0 1 1 1 0 Nucleotidyltransferase-like Kelch_6 PF13964.6 ETO31912.1 - 0.0031 17.8 0.2 1.3 9.4 0.1 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO31912.1 - 0.01 15.4 0.1 0.2 11.2 0.0 2.9 3 0 0 3 3 3 0 Kelch motif Kelch_4 PF13418.6 ETO31912.1 - 0.022 14.8 0.1 0.11 12.5 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO31912.1 - 0.028 14.7 0.1 0.34 11.2 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO31912.1 - 0.15 12.1 0.1 7 6.8 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETO31912.1 - 0.86 9.7 4.4 0.3 11.1 0.2 2.5 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO31913.1 - 0.055 14.4 4.4 0.37 11.7 1.0 2.7 2 1 0 2 2 2 0 WD domain, G-beta repeat PBP_sp32 PF07222.12 ETO31913.1 - 0.18 11.2 1.7 0.29 10.5 1.7 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 WRNPLPNID PF15017.6 ETO31913.1 - 1.7 9.6 12.3 1.3 10.0 10.2 1.9 2 0 0 2 2 2 0 Putative WW-binding domain and destruction box FAM176 PF14851.6 ETO31913.1 - 5.8 6.6 7.0 9.3 5.9 7.0 1.4 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO31913.1 - 6.8 5.9 14.3 0.93 8.8 10.8 1.4 2 0 0 2 2 2 0 NOA36 protein La PF05383.17 ETO31914.1 - 8e-18 64.3 0.8 1.7e-17 63.2 0.8 1.6 1 0 0 1 1 1 1 La domain PTPS PF01242.19 ETO31914.1 - 0.062 13.3 0.2 0.1 12.6 0.2 1.5 1 1 0 1 1 1 0 6-pyruvoyl tetrahydropterin synthase RP-C_C PF11800.8 ETO31914.1 - 2 8.5 8.1 3 7.9 8.1 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region LtrA PF06772.11 ETO31916.1 - 1.6e-08 34.2 11.9 2e-08 33.8 11.9 1.1 1 0 0 1 1 1 1 Bacterial low temperature requirement A protein (LtrA) Plasmodium_Vir PF05795.11 ETO31917.1 - 0.00011 21.8 3.4 0.00014 21.5 3.4 1.1 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF2207 PF09972.9 ETO31917.1 - 0.00011 21.1 0.1 0.00014 20.8 0.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) Tim54 PF11711.8 ETO31917.1 - 0.00064 18.6 2.3 0.00075 18.4 2.3 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF2457 PF10446.9 ETO31917.1 - 0.0036 16.5 15.1 0.0043 16.2 15.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) TFIIF_alpha PF05793.12 ETO31917.1 - 0.008 14.8 25.8 0.01 14.5 25.8 1.0 1 0 0 1 1 1 1 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Cwf_Cwc_15 PF04889.12 ETO31917.1 - 0.059 13.1 18.1 0.075 12.8 18.1 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DDHD PF02862.17 ETO31917.1 - 0.061 13.5 3.3 0.074 13.2 3.3 1.2 1 0 0 1 1 1 0 DDHD domain Strabismus PF06638.11 ETO31917.1 - 0.066 11.9 2.8 0.085 11.5 2.8 1.2 1 0 0 1 1 1 0 Strabismus protein AF-4 PF05110.13 ETO31917.1 - 0.08 11.0 13.6 0.094 10.8 13.6 1.0 1 0 0 1 1 1 0 AF-4 proto-oncoprotein AAA_11 PF13086.6 ETO31917.1 - 0.19 11.5 11.5 0.23 11.2 11.5 1.1 1 0 0 1 1 1 0 AAA domain SLC12 PF03522.15 ETO31917.1 - 0.27 10.2 10.4 0.32 10.0 10.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 PPL5 PF18168.1 ETO31917.1 - 0.28 10.5 11.2 0.36 10.1 11.2 1.1 1 0 0 1 1 1 0 Prim-pol family 5 DUF4746 PF15928.5 ETO31917.1 - 0.32 10.4 12.3 0.37 10.2 12.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Jak1_Phl PF17887.1 ETO31917.1 - 0.36 10.8 14.3 0.68 9.9 10.0 2.0 1 1 1 2 2 2 0 Jak1 pleckstrin homology-like domain NPR3 PF03666.13 ETO31917.1 - 0.38 9.5 12.4 0.46 9.2 12.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Nop14 PF04147.12 ETO31917.1 - 0.65 8.1 17.7 0.71 8.0 17.7 1.0 1 0 0 1 1 1 0 Nop14-like family Paf1 PF03985.13 ETO31917.1 - 0.71 8.8 20.6 0.82 8.6 20.6 1.1 1 0 0 1 1 1 0 Paf1 Vfa1 PF08432.10 ETO31917.1 - 1.5 9.1 17.4 2 8.7 17.4 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 RNA_pol_Rpc4 PF05132.14 ETO31917.1 - 2 8.8 10.2 2.8 8.3 10.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 NARP1 PF12569.8 ETO31917.1 - 2 7.2 14.5 2.4 7.0 14.5 1.0 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 RP-C_C PF11800.8 ETO31917.1 - 2.2 8.3 6.3 2.8 8.0 6.3 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region Trypan_PARP PF05887.11 ETO31917.1 - 3 7.8 7.6 4.8 7.2 7.6 1.4 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) DUF4820 PF16091.5 ETO31917.1 - 4.8 6.5 13.5 9 5.6 13.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) CDC45 PF02724.14 ETO31917.1 - 5.9 5.1 17.2 7.1 4.8 17.2 1.1 1 0 0 1 1 1 0 CDC45-like protein PTPRCAP PF15713.5 ETO31917.1 - 6.7 7.0 19.4 9.1 6.6 19.4 1.1 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated DUF2370 PF10176.9 ETO31917.1 - 9.2 5.8 8.2 15 5.2 8.2 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2370) zf-PARP PF00645.18 ETO31918.1 - 0.034 15.0 2.7 0.056 14.3 0.1 2.2 1 1 1 2 2 2 0 Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region WD40 PF00400.32 ETO31920.1 - 1.9e-13 50.6 5.2 2.4e-06 28.2 0.7 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31920.1 - 2.8e-07 30.8 0.3 0.066 13.5 0.0 3.9 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31920.1 - 0.075 11.7 2.0 0.92 8.1 0.1 2.8 2 1 0 2 2 2 0 Nucleoporin Nup120/160 HAGH_C PF16123.5 ETO31920.1 - 0.12 12.9 0.0 6.1 7.4 0.0 2.3 2 0 0 2 2 2 0 Hydroxyacylglutathione hydrolase C-terminus WD40 PF00400.32 ETO31921.1 - 4.7e-34 115.8 28.2 8.1e-06 26.5 2.3 8.0 7 2 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31921.1 - 1.4e-12 47.7 2.7 0.0059 16.9 0.1 5.3 4 1 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31921.1 - 1.5e-11 43.7 8.5 0.0012 17.5 0.2 4.3 2 1 1 4 4 4 4 Nucleoporin Nup120/160 DUF5096 PF17019.5 ETO31921.1 - 0.011 15.5 0.8 0.16 11.8 0.7 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5096) AAA_14 PF13173.6 ETO31921.1 - 0.097 12.7 0.3 0.29 11.2 0.3 1.8 1 0 0 1 1 1 0 AAA domain WD40 PF00400.32 ETO31922.1 - 1.3e-22 79.6 15.9 1.7e-07 31.8 0.6 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO31922.1 - 2.4e-06 26.5 0.7 0.0032 16.2 0.1 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO31922.1 - 5e-06 26.7 0.1 0.099 13.0 0.0 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO31922.1 - 0.0012 18.2 0.5 0.0096 15.3 0.3 2.1 2 0 0 2 2 2 1 WD40-like domain W_rich_C PF07483.11 ETO31922.1 - 0.019 15.1 0.4 0.039 14.1 0.4 1.5 1 0 0 1 1 1 0 Tryptophan-rich Synechocystis species C-terminal domain DUF4221 PF13970.6 ETO31922.1 - 0.02 14.5 4.2 0.032 13.8 4.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4221) UNC-93 PF05978.16 ETO31922.1 - 0.04 13.6 1.6 0.19 11.4 1.1 2.1 2 0 0 2 2 2 0 Ion channel regulatory protein UNC-93 NPR2 PF06218.11 ETO31922.1 - 0.14 10.9 2.9 0.19 10.5 2.9 1.0 1 0 0 1 1 1 0 Nitrogen permease regulator 2 DIM1 PF02966.16 ETO31922.1 - 6.1 6.6 5.9 12 5.7 0.4 2.2 1 1 1 2 2 2 0 Mitosis protein DIM1 HEAT PF02985.22 ETO31923.1 - 0.0035 17.5 0.1 1.8 9.0 0.0 3.8 4 0 0 4 4 4 1 HEAT repeat RIX1 PF08167.12 ETO31923.1 - 0.0049 16.6 1.2 0.012 15.4 1.2 1.6 1 1 0 1 1 1 1 rRNA processing/ribosome biogenesis CTK3 PF12243.8 ETO31923.1 - 0.0066 16.4 0.1 0.098 12.7 0.1 2.1 2 0 0 2 2 2 1 CTD kinase subunit gamma CTK3 AAA PF00004.29 ETO31923.1 - 0.016 15.7 0.3 0.032 14.6 0.3 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DnaB PF00772.21 ETO31923.1 - 0.018 15.1 0.3 0.4 10.8 0.1 2.3 2 1 0 2 2 2 0 DnaB-like helicase N terminal domain RTP1_C1 PF10363.9 ETO31923.1 - 0.024 14.8 0.2 11 6.2 0.0 3.3 2 1 1 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Sec62 PF03839.16 ETO31924.1 - 0.046 13.2 0.4 0.061 12.8 0.4 1.1 1 0 0 1 1 1 0 Translocation protein Sec62 Bcl-2_BAD PF10514.9 ETO31924.1 - 0.067 13.7 0.0 0.09 13.2 0.0 1.2 1 0 0 1 1 1 0 Pro-apoptotic Bcl-2 protein, BAD DUF3292 PF11696.8 ETO31924.1 - 0.09 11.1 2.6 0.12 10.8 2.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3292) MAP17 PF15807.5 ETO31924.1 - 1.2 9.4 4.5 1.7 8.9 4.5 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Atrophin-1 PF03154.15 ETO31924.1 - 1.3 7.2 4.1 1.6 6.9 4.1 1.0 1 0 0 1 1 1 0 Atrophin-1 family Nucleoside_tran PF01733.18 ETO31929.1 - 0.0045 16.4 0.1 0.0067 15.9 0.1 1.3 1 0 0 1 1 1 1 Nucleoside transporter DUF1754 PF08555.10 ETO31929.1 - 3.3 8.6 11.1 0.15 12.9 1.8 2.2 2 0 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Acetyltransf_CG PF14542.6 ETO31930.1 - 1.4e-12 47.6 0.1 1.9e-12 47.1 0.1 1.2 1 0 0 1 1 1 1 GCN5-related N-acetyl-transferase Acetyltransf_1 PF00583.25 ETO31930.1 - 0.013 15.8 0.0 0.017 15.4 0.0 1.2 1 0 0 1 1 1 0 Acetyltransferase (GNAT) family FR47 PF08445.10 ETO31930.1 - 0.025 14.5 0.0 0.038 13.9 0.0 1.4 1 0 0 1 1 1 0 FR47-like protein Acetyltransf_3 PF13302.7 ETO31930.1 - 0.087 13.5 0.0 0.11 13.2 0.0 1.1 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO31930.1 - 0.12 12.8 0.0 0.16 12.4 0.0 1.4 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain SAM_2 PF07647.17 ETO31931.1 - 3.1e-10 40.0 0.3 7e-10 38.9 0.3 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO31931.1 - 4.7e-08 33.3 0.5 8.4e-08 32.6 0.5 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SlyX PF04102.12 ETO31931.1 - 0.00084 19.9 9.5 0.0016 19.0 4.2 2.9 2 1 1 3 3 3 1 SlyX bZIP_1 PF00170.21 ETO31931.1 - 0.028 14.5 4.1 0.028 14.5 4.1 2.5 3 0 0 3 3 3 0 bZIP transcription factor Bacillus_HBL PF05791.11 ETO31931.1 - 0.076 12.8 3.9 0.41 10.5 2.1 2.3 2 0 0 2 2 2 0 Bacillus haemolytic enterotoxin (HBL) ALMT PF11744.8 ETO31931.1 - 0.22 10.3 6.6 0.055 12.3 3.6 1.5 2 0 0 2 2 2 0 Aluminium activated malate transporter FapA PF03961.13 ETO31931.1 - 0.25 9.9 7.7 5.2 5.6 6.7 2.1 1 1 1 2 2 2 0 Flagellar Assembly Protein A Allexi_40kDa PF05549.11 ETO31931.1 - 0.35 10.4 5.1 0.11 12.0 2.5 1.5 2 0 0 2 2 2 0 Allexivirus 40kDa protein FTO_NTD PF12933.7 ETO31931.1 - 0.44 9.8 3.9 0.14 11.4 1.3 1.5 2 0 0 2 2 2 0 FTO catalytic domain SHE3 PF17078.5 ETO31931.1 - 0.5 10.0 11.9 0.055 13.2 7.0 1.9 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 Fib_alpha PF08702.10 ETO31931.1 - 0.69 10.1 9.5 0.46 10.7 4.1 2.8 2 1 1 3 3 3 0 Fibrinogen alpha/beta chain family EMC3_TMCO1 PF01956.16 ETO31931.1 - 0.94 9.2 3.0 1.9 8.2 3.0 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like DUF16 PF01519.16 ETO31931.1 - 1.1 9.8 8.3 4.9 7.7 6.6 2.7 2 1 0 2 2 2 0 Protein of unknown function DUF16 Holin_BhlA PF10960.8 ETO31931.1 - 1.2 9.2 5.0 0.62 10.1 1.8 2.1 2 0 0 2 2 2 0 BhlA holin family BORCS8 PF10167.9 ETO31931.1 - 1.4 8.9 5.6 1.8 8.5 2.7 2.2 2 0 0 2 2 2 0 BLOC-1-related complex sub-unit 8 XhlA PF10779.9 ETO31931.1 - 2.1 8.6 4.6 1.2 9.4 1.8 2.0 2 0 0 2 2 2 0 Haemolysin XhlA Prefoldin PF02996.17 ETO31931.1 - 3.3 7.6 10.1 0.54 10.2 3.3 2.7 2 1 1 3 3 3 0 Prefoldin subunit DivIC PF04977.15 ETO31931.1 - 4.6 7.1 7.1 1.1 9.1 3.3 2.0 2 1 0 2 2 2 0 Septum formation initiator Exonuc_VII_L PF02601.15 ETO31931.1 - 4.8 6.6 12.3 38 3.7 12.3 2.0 1 1 0 1 1 1 0 Exonuclease VII, large subunit PRIMA1 PF16101.5 ETO31932.1 - 4.7 7.3 15.3 0.4 10.7 9.9 2.1 2 0 0 2 2 2 0 Proline-rich membrane anchor 1 GlcNAc PF11397.8 ETO31933.1 - 1.9e-17 63.8 0.4 6.8e-13 48.8 0.2 2.1 1 1 1 2 2 2 2 Glycosyltransferase (GlcNAc) KBP_C PF12309.8 ETO31934.1 - 0.84 9.1 6.5 1.1 8.7 6.5 1.2 1 0 0 1 1 1 0 KIF-1 binding protein C terminal ETRAMP PF09716.10 ETO31934.1 - 1.2 9.3 2.9 2.3 8.4 2.9 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) BUD22 PF09073.10 ETO31934.1 - 3.9 6.7 26.2 4.7 6.4 26.2 1.1 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO31934.1 - 4.6 5.9 9.8 6 5.5 9.8 1.3 1 0 0 1 1 1 0 Presenilin PNISR PF15996.5 ETO31934.1 - 4.8 7.4 18.9 7.3 6.8 18.9 1.3 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR Phage_TAC_13 PF16459.5 ETO31935.1 - 0.1 13.1 0.0 0.21 12.1 0.0 1.6 2 0 0 2 2 2 0 Phage tail assembly chaperone, TAC Kinesin PF00225.23 ETO31937.1 - 1.9e-29 102.7 0.1 1.9e-29 102.7 0.1 2.0 2 0 0 2 2 2 1 Kinesin motor domain CENP-H PF05837.12 ETO31937.1 - 6.9 7.1 12.2 2.6 8.5 8.6 2.1 3 0 0 3 3 3 0 Centromere protein H (CENP-H) ATP-synt_D PF01813.17 ETO31939.1 - 3e-24 85.9 0.2 4.5e-24 85.4 0.2 1.2 1 0 0 1 1 1 1 ATP synthase subunit D Methyltransf_11 PF08241.12 ETO31941.1 - 2.7e-15 56.8 0.0 6e-15 55.7 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO31941.1 - 3.8e-15 56.4 0.1 8.5e-15 55.2 0.1 1.6 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO31941.1 - 3.5e-13 49.6 0.9 1.7e-12 47.4 0.9 2.1 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO31941.1 - 1.1e-12 48.1 0.1 2.1e-12 47.2 0.1 1.5 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO31941.1 - 3e-09 37.5 0.1 9.3e-09 35.9 0.1 1.9 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO31941.1 - 2e-08 33.9 0.1 3.5e-08 33.1 0.1 1.4 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family MetW PF07021.12 ETO31941.1 - 7.6e-08 32.2 0.2 1.4e-07 31.3 0.2 1.4 1 0 0 1 1 1 1 Methionine biosynthesis protein MetW DREV PF05219.12 ETO31941.1 - 0.00078 18.6 0.1 0.0013 17.9 0.1 1.3 1 0 0 1 1 1 1 DREV methyltransferase Methyltransf_29 PF03141.16 ETO31941.1 - 0.011 14.3 0.1 0.011 14.3 0.1 2.5 3 0 0 3 3 3 0 Putative S-adenosyl-L-methionine-dependent methyltransferase MTS PF05175.14 ETO31941.1 - 0.013 15.1 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 Methyltransferase small domain NodS PF05401.11 ETO31941.1 - 0.039 13.6 0.0 0.074 12.7 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein S (NodS) Methyltransf_32 PF13679.6 ETO31941.1 - 0.11 12.5 0.1 0.11 12.5 0.1 2.6 1 1 0 2 2 2 0 Methyltransferase domain DEAD PF00270.29 ETO31942.1 - 7.3e-13 48.7 0.1 1.5e-12 47.6 0.1 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase Helicase_C PF00271.31 ETO31942.1 - 2.1e-12 47.3 0.0 1e-11 45.2 0.0 2.2 2 0 0 2 2 2 1 Helicase conserved C-terminal domain RQC PF09382.10 ETO31942.1 - 2.3e-08 33.8 1.4 6.5e-08 32.4 0.4 2.1 2 0 0 2 2 2 1 RQC domain RecQ_Zn_bind PF16124.5 ETO31942.1 - 9.1e-08 32.7 8.0 3.4e-07 30.9 8.0 2.1 1 0 0 1 1 1 1 RecQ zinc-binding 4HB_MCP_1 PF12729.7 ETO31943.1 - 0.0091 15.6 0.0 0.021 14.4 0.0 1.6 1 0 0 1 1 1 1 Four helix bundle sensory module for signal transduction Pox_A21 PF05323.12 ETO31943.1 - 0.13 12.8 2.8 5.4 7.6 0.1 3.2 2 1 1 3 3 3 0 Poxvirus A21 Protein GPS PF01825.21 ETO31944.1 - 4.1e-09 36.8 7.0 3.6e-08 33.8 7.0 2.8 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif DUF2847 PF11009.8 ETO31945.1 - 0.085 12.8 0.2 0.085 12.8 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2847) ResIII PF04851.15 ETO31946.1 - 3.8e-07 30.3 0.0 6.1e-07 29.6 0.0 1.3 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit DEAD_2 PF06733.15 ETO31946.1 - 0.0003 20.4 4.7 0.016 14.8 0.1 2.7 3 0 0 3 3 3 2 DEAD_2 DEAD PF00270.29 ETO31946.1 - 0.00067 19.5 0.0 0.00097 18.9 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase DUF853 PF05872.12 ETO31946.1 - 0.011 14.3 0.0 0.016 13.8 0.0 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) AAA_11 PF13086.6 ETO31946.1 - 0.015 15.1 0.0 0.019 14.7 0.0 1.2 1 0 0 1 1 1 0 AAA domain vWF_A PF12450.8 ETO31946.1 - 0.069 13.1 0.4 0.21 11.5 0.1 1.9 2 0 0 2 2 2 0 von Willebrand factor Exog_C PF18026.1 ETO31946.1 - 0.09 12.9 0.1 0.24 11.5 0.0 1.7 2 0 0 2 2 2 0 Endo/exonuclease (EXOG) C-terminal domain AAA_19 PF13245.6 ETO31946.1 - 0.098 13.0 0.0 0.14 12.5 0.0 1.2 1 0 0 1 1 1 0 AAA domain Rx_N PF18052.1 ETO31946.1 - 0.12 12.7 0.0 0.18 12.1 0.0 1.2 1 0 0 1 1 1 0 Rx N-terminal domain DUF262 PF03235.14 ETO31948.1 - 1.6 8.8 12.5 1.8 8.7 12.5 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF262 Caldesmon PF02029.15 ETO31948.1 - 2.6 6.7 46.3 2.9 6.6 46.3 1.0 1 0 0 1 1 1 0 Caldesmon Nop14 PF04147.12 ETO31948.1 - 3.2 5.8 56.7 3.8 5.6 56.7 1.2 1 0 0 1 1 1 0 Nop14-like family YL1 PF05764.13 ETO31948.1 - 8.1 6.5 53.5 13 5.8 53.5 1.3 1 0 0 1 1 1 0 YL1 nuclear protein CCSAP PF15748.5 ETO31948.1 - 9.4 6.3 30.7 13 5.9 30.7 1.2 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated NPL PF17800.1 ETO31949.1 - 1.2e-06 29.0 0.0 4.9e-06 27.0 0.0 2.0 1 1 0 1 1 1 1 Nucleoplasmin-like domain YL1 PF05764.13 ETO31949.1 - 3.6e-05 24.0 5.4 3.7e-05 24.0 5.4 1.1 1 0 0 1 1 1 1 YL1 nuclear protein Ank_4 PF13637.6 ETO31950.1 - 7.7e-10 39.1 0.2 1.1e-06 29.1 0.0 2.0 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO31950.1 - 1.3e-08 34.9 0.0 4.2e-08 33.3 0.0 1.9 1 1 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO31950.1 - 1.5e-07 31.9 0.0 2.3e-07 31.3 0.0 1.3 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO31950.1 - 1.6e-07 31.1 0.0 0.0018 18.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank PF00023.30 ETO31950.1 - 0.00068 20.0 0.0 0.62 10.6 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat DUF2634 PF10934.8 ETO31950.1 - 0.082 13.0 0.5 0.24 11.5 0.2 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF2634) zf-HC2 PF13490.6 ETO31950.1 - 0.15 12.4 0.2 0.37 11.1 0.2 1.8 1 1 0 1 1 1 0 Putative zinc-finger Cwf_Cwc_15 PF04889.12 ETO31952.1 - 1.4 8.5 17.0 0.1 12.3 11.8 1.7 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein DUF3682 PF12446.8 ETO31952.1 - 6.1 7.3 15.7 14 6.2 15.7 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) 2OG-FeII_Oxy_3 PF13640.6 ETO31953.1 - 1.1e-06 29.4 0.0 1.1e-05 26.3 0.0 2.1 1 1 1 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ETO31953.1 - 0.00096 19.6 0.0 0.0017 18.8 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Dna2 PF08696.11 ETO31953.1 - 0.49 10.2 4.1 6.1 6.6 0.5 2.5 1 1 0 2 2 2 0 DNA replication factor Dna2 TPR_1 PF00515.28 ETO31954.1 - 1e-15 56.7 10.9 1.5e-08 34.0 1.7 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31954.1 - 1e-13 50.2 5.2 1.6e-07 30.9 0.4 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31954.1 - 2.7e-12 45.8 0.9 3.2e-05 23.7 0.1 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO31954.1 - 1.5e-11 44.4 2.2 8.5e-11 42.0 2.2 1.8 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31954.1 - 2.5e-09 36.6 7.4 7.1e-06 25.8 1.5 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO31954.1 - 1.1e-08 34.6 6.2 0.00019 21.2 0.3 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31954.1 - 1.3e-07 31.1 13.7 1.2e-05 24.9 1.5 3.6 3 1 1 4 4 4 3 TPR repeat TPR_6 PF13174.6 ETO31954.1 - 3.9e-07 30.3 0.1 0.016 15.8 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31954.1 - 1.8e-06 28.4 0.0 1.2e-05 25.9 0.0 1.9 1 1 0 1 1 1 1 Tetratricopeptide repeat RPN7 PF10602.9 ETO31954.1 - 4.3e-06 26.6 1.0 0.0017 18.1 0.4 2.0 1 1 1 2 2 2 2 26S proteasome subunit RPN7 SNAP PF14938.6 ETO31954.1 - 2.6e-05 23.8 1.8 4.8e-05 22.9 1.8 1.5 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO31954.1 - 6.2e-05 23.1 8.2 0.027 14.8 0.3 3.4 2 1 0 3 3 3 2 Tetratricopeptide repeat TPR_5 PF12688.7 ETO31954.1 - 0.00043 20.5 0.0 0.0017 18.6 0.0 1.8 1 1 0 1 1 1 1 Tetratrico peptide repeat TPR_14 PF13428.6 ETO31954.1 - 0.0011 19.6 0.0 1 10.4 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETO31954.1 - 0.0077 16.0 0.3 1.8 8.3 0.0 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat-like domain TPR_MalT PF17874.1 ETO31954.1 - 0.015 14.7 0.0 0.017 14.5 0.0 1.0 1 0 0 1 1 1 0 MalT-like TPR region ANAPC3 PF12895.7 ETO31954.1 - 0.026 14.7 2.0 0.078 13.2 0.8 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO31954.1 - 0.028 14.5 4.8 2.2 8.4 0.3 2.2 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO31954.1 - 0.029 14.6 1.5 6.7 7.2 0.3 2.3 2 0 0 2 2 2 0 PPR repeat TPR_19 PF14559.6 ETO31954.1 - 0.097 13.2 0.4 6.9 7.3 0.0 2.2 1 1 2 3 3 2 0 Tetratricopeptide repeat NSF PF02071.20 ETO31954.1 - 0.24 12.3 3.8 7 7.9 0.1 3.0 3 0 0 3 3 2 0 Aromatic-di-Alanine (AdAR) repeat Sda PF08970.10 ETO31954.1 - 2.5 7.9 4.5 9.6 6.0 0.0 2.9 2 2 2 4 4 4 0 Sporulation inhibitor A Pkinase PF00069.25 ETO31955.1 - 4.6e-37 127.8 0.0 5.1e-25 88.3 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31955.1 - 3.3e-24 85.6 0.0 4.7e-17 62.1 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase SelP_N PF04592.14 ETO31955.1 - 0.21 11.0 12.7 0.33 10.3 12.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region Zip PF02535.22 ETO31955.1 - 0.23 10.6 2.8 0.27 10.4 2.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter ATP11 PF06644.11 ETO31956.1 - 1.3e-10 41.6 0.3 1.6e-10 41.3 0.3 1.1 1 0 0 1 1 1 1 ATP11 protein WD40 PF00400.32 ETO31957.1 - 7.7e-51 169.0 3.2 1.3e-10 41.7 0.0 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31957.1 - 1.3e-22 79.9 0.1 0.00029 21.1 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO31957.1 - 1.8e-11 44.3 0.0 3.4e-07 30.3 0.0 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO31957.1 - 2.9e-11 42.9 0.0 0.081 11.9 0.0 4.9 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO31957.1 - 1.8e-08 33.5 0.6 0.77 8.3 0.0 4.2 2 1 1 4 4 4 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO31957.1 - 3.4e-06 26.8 3.9 2.5 8.1 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO31957.1 - 0.00011 20.9 0.0 0.014 14.0 0.0 2.4 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO31957.1 - 0.00028 21.0 0.2 12 6.0 0.0 4.6 2 2 3 5 5 5 1 Family of unknown function (DUF5570) WD40_like PF17005.5 ETO31957.1 - 0.00031 20.2 0.0 1.5 8.0 0.0 3.6 1 1 3 4 4 4 2 WD40-like domain Proteasome_A_N PF10584.9 ETO31957.1 - 0.00043 19.9 1.9 26 4.6 0.0 5.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Nbas_N PF15492.6 ETO31957.1 - 0.0005 19.5 0.8 0.82 8.9 0.0 3.7 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Coatomer_WDAD PF04053.14 ETO31957.1 - 0.0025 17.0 0.0 0.049 12.7 0.0 2.5 1 1 2 3 3 3 2 Coatomer WD associated region Me-amine-dh_H PF06433.11 ETO31957.1 - 0.029 13.2 0.0 0.075 11.9 0.0 1.7 1 0 0 1 1 1 0 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 ETO31957.1 - 0.054 13.1 0.0 0.11 12.0 0.0 1.6 1 1 0 1 1 1 0 PQQ-like domain adh_short PF00106.25 ETO31959.1 - 1.2e-46 158.7 0.2 1.3e-46 158.5 0.2 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO31959.1 - 3.3e-33 115.2 0.1 3.7e-33 115.0 0.1 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO31959.1 - 9.3e-12 45.2 0.0 1.2e-11 44.9 0.0 1.1 1 0 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETO31959.1 - 8.6e-05 22.5 0.0 0.00018 21.4 0.0 1.5 1 1 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETO31959.1 - 0.00067 19.2 0.0 0.007 15.9 0.0 2.2 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family WD40 PF00400.32 ETO31961.1 - 2.4e-35 120.0 22.9 1.6e-05 25.5 1.1 6.9 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31961.1 - 2e-11 44.0 3.4 0.0009 19.5 0.0 5.2 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31961.1 - 2.3e-07 29.9 7.9 0.0048 15.6 0.1 4.8 2 2 3 5 5 5 4 Nucleoporin Nup120/160 W_rich_C PF07483.11 ETO31961.1 - 0.25 11.5 3.2 0.39 10.9 0.3 2.7 2 1 0 2 2 2 0 Tryptophan-rich Synechocystis species C-terminal domain DUF5570 PF17731.1 ETO31961.1 - 0.41 10.8 1.3 34 4.5 0.1 3.0 2 1 1 3 3 3 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO31962.1 - 6e-36 121.8 25.6 1.9e-07 31.6 0.4 8.0 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31962.1 - 1.4e-10 41.4 2.6 0.022 15.0 0.0 5.4 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31962.1 - 2.2e-08 33.2 12.4 0.00037 19.3 2.3 5.0 2 2 0 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO31964.1 - 1.6e-38 129.9 29.4 2.3e-07 31.4 0.6 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31964.1 - 6.2e-09 36.0 1.1 0.11 12.8 0.0 5.3 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31964.1 - 6.3e-08 31.7 5.2 0.094 11.3 0.3 5.5 1 1 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO31964.1 - 8.9e-06 25.2 4.1 0.00053 19.4 0.3 3.8 2 2 1 4 4 4 1 WD40-like domain SH3_13 PF18335.1 ETO31964.1 - 0.23 11.3 1.3 1.8 8.5 0.1 2.9 4 0 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain WD40 PF00400.32 ETO31965.1 - 1.9e-44 148.7 32.8 1.1e-07 32.4 0.1 7.4 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31965.1 - 6e-12 45.7 4.7 0.0067 16.7 0.1 5.3 3 1 2 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31965.1 - 1e-07 31.0 6.2 0.37 9.4 0.1 5.4 2 1 3 5 5 5 4 Nucleoporin Nup120/160 Kelch_5 PF13854.6 ETO31966.1 - 7.4e-06 25.8 2.2 0.46 10.5 0.0 4.6 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO31966.1 - 0.001 19.0 1.2 3.7 7.7 0.0 3.9 3 1 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO31966.1 - 0.024 14.9 0.6 26 5.3 0.0 3.7 3 0 0 3 3 3 0 Kelch motif Kelch_1 PF01344.25 ETO31966.1 - 0.045 13.3 2.0 6.7 6.4 0.5 2.8 2 1 0 2 2 2 0 Kelch motif Pkinase PF00069.25 ETO31967.1 - 6.6e-14 51.9 0.2 9.2e-14 51.4 0.2 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31967.1 - 1.2e-06 28.0 0.2 1.6e-06 27.6 0.2 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO31968.1 - 1.7e-23 83.3 0.2 8.3e-23 81.1 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO31968.1 - 7.9e-09 35.2 0.0 1.2e-07 31.3 0.0 2.4 1 1 0 1 1 1 1 Protein tyrosine kinase KA1 PF02149.19 ETO31968.1 - 0.00087 19.0 0.1 0.0034 17.1 0.1 2.0 1 1 0 1 1 1 1 Kinase associated domain 1 DUF812 PF05667.11 ETO31968.1 - 0.84 8.4 5.2 0.43 9.4 0.1 2.4 2 1 1 3 3 3 0 Protein of unknown function (DUF812) Choline_transpo PF04515.12 ETO31969.1 - 1.5e-62 211.7 26.7 1.5e-62 211.7 26.7 1.7 2 0 0 2 2 2 1 Plasma-membrane choline transporter Iron_permease PF04120.12 ETO31969.1 - 0.00046 20.0 0.0 0.001 18.9 0.0 1.6 1 0 0 1 1 1 1 Low affinity iron permease FixH PF05751.11 ETO31969.1 - 0.003 17.6 0.0 0.01 15.9 0.0 1.9 1 0 0 1 1 1 1 FixH SpoIIM PF01944.17 ETO31970.1 - 0.4 10.7 1.4 4.1 7.4 1.6 2.0 1 1 1 2 2 2 0 Stage II sporulation protein M OATP PF03137.20 ETO31970.1 - 0.63 8.2 5.3 0.73 8.1 5.3 1.2 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Presenilin PF01080.17 ETO31970.1 - 1.4 7.6 3.1 1.5 7.5 3.1 1.1 1 0 0 1 1 1 0 Presenilin SET PF00856.28 ETO31971.1 - 2.4e-22 80.1 0.7 2.4e-22 80.1 0.7 3.1 2 2 0 2 2 2 1 SET domain DUF4746 PF15928.5 ETO31972.1 - 1 8.7 13.3 1.1 8.6 13.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CDC45 PF02724.14 ETO31972.1 - 2.4 6.4 11.6 2.2 6.4 11.6 1.1 1 0 0 1 1 1 0 CDC45-like protein CobT PF06213.12 ETO31972.1 - 4.5 6.6 15.4 5.5 6.3 15.4 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT NOA36 PF06524.12 ETO31972.1 - 6.1 6.1 15.8 7 5.9 15.8 1.2 1 0 0 1 1 1 0 NOA36 protein ANAPC4_WD40 PF12894.7 ETO31974.1 - 1e-08 35.4 0.4 0.0059 16.9 0.1 3.6 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO31974.1 - 2.4e-07 31.3 7.4 0.044 14.7 0.0 5.2 5 1 0 5 5 5 2 WD domain, G-beta repeat PQQ PF01011.21 ETO31974.1 - 0.0038 17.1 0.0 0.51 10.4 0.0 3.3 3 0 0 3 3 3 1 PQQ enzyme repeat IKI3 PF04762.12 ETO31974.1 - 0.0071 14.4 0.1 0.12 10.3 0.0 2.0 1 1 1 2 2 2 2 IKI3 family TFIIIC_delta PF12657.7 ETO31974.1 - 0.069 13.1 0.1 0.58 10.1 0.0 2.4 2 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Ge1_WD40 PF16529.5 ETO31974.1 - 0.091 11.7 0.1 0.35 9.8 0.0 2.0 2 1 0 2 2 2 0 WD40 region of Ge1, enhancer of mRNA-decapping protein Peptidase_C12 PF01088.21 ETO31975.1 - 4.5e-50 170.3 0.0 4.5e-50 170.3 0.0 1.4 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase, family 1 SNARE_assoc PF09335.11 ETO31976.1 - 2.2e-09 37.8 4.9 2.2e-09 37.8 4.9 1.9 2 1 0 2 2 2 1 SNARE associated Golgi protein UQ_con PF00179.26 ETO31979.1 - 2.6e-28 98.4 0.5 5.1e-28 97.5 0.4 1.7 1 1 0 1 1 1 1 Ubiquitin-conjugating enzyme SAPS PF04499.15 ETO31979.1 - 0.11 11.2 10.1 0.096 11.5 10.1 1.1 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein CDC45 PF02724.14 ETO31979.1 - 0.27 9.5 26.8 0.41 8.9 26.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Trypan_PARP PF05887.11 ETO31979.1 - 0.37 10.8 8.6 0.54 10.2 8.6 1.3 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Nop14 PF04147.12 ETO31979.1 - 0.61 8.2 24.1 0.77 7.9 24.1 1.2 1 0 0 1 1 1 0 Nop14-like family RNA_pol_Rpc4 PF05132.14 ETO31979.1 - 0.62 10.5 14.2 0.28 11.6 11.9 1.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 Atrophin-1 PF03154.15 ETO31979.1 - 0.92 7.7 14.9 1.4 7.1 14.9 1.4 1 0 0 1 1 1 0 Atrophin-1 family Presenilin PF01080.17 ETO31979.1 - 0.93 8.2 15.5 1.2 7.9 15.5 1.2 1 0 0 1 1 1 0 Presenilin Cytomega_UL84 PF06284.11 ETO31979.1 - 1.1 7.7 6.9 1.1 7.7 6.9 1.2 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Rrn6 PF10214.9 ETO31979.1 - 1.1 7.6 21.6 1.4 7.3 21.7 1.2 1 1 0 1 1 1 0 RNA polymerase I-specific transcription-initiation factor Merozoite_SPAM PF07133.11 ETO31979.1 - 1.8 8.5 34.0 2.8 7.9 34.0 1.3 1 0 0 1 1 1 0 Merozoite surface protein (SPAM) RNA_polI_A34 PF08208.11 ETO31979.1 - 2 8.5 28.1 0.27 11.3 21.5 2.0 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 eIF-3c_N PF05470.12 ETO31979.1 - 2.2 6.5 16.8 3 6.0 16.8 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus NOA36 PF06524.12 ETO31979.1 - 2.2 7.5 16.4 3.3 7.0 16.4 1.3 1 0 0 1 1 1 0 NOA36 protein DDHD PF02862.17 ETO31979.1 - 2.6 8.2 10.0 2.6 8.2 9.2 1.5 2 0 0 2 2 2 0 DDHD domain Zip PF02535.22 ETO31979.1 - 3.1 6.9 12.3 4 6.6 12.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Vfa1 PF08432.10 ETO31979.1 - 4.1 7.7 26.0 1.1 9.5 22.4 1.8 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF913 PF06025.12 ETO31979.1 - 4.1 6.3 12.0 5.5 5.9 12.0 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) DUF1168 PF06658.12 ETO31979.1 - 6.3 6.6 33.8 0.12 12.2 25.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1168) NARP1 PF12569.8 ETO31979.1 - 6.6 5.5 19.3 8.9 5.1 19.3 1.3 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 Hid1 PF12722.7 ETO31979.1 - 7.3 4.6 14.7 8.2 4.4 14.7 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein HxlR PF01638.17 ETO31981.1 - 0.013 15.4 0.1 0.049 13.5 0.0 1.9 2 1 0 2 2 2 0 HxlR-like helix-turn-helix DUF3937 PF13073.6 ETO31981.1 - 0.043 13.9 0.0 0.19 11.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3937) Polysacc_deac_2 PF04748.13 ETO31981.1 - 0.16 11.1 0.0 0.2 10.8 0.0 1.1 1 0 0 1 1 1 0 Divergent polysaccharide deacetylase Cul7 PF11515.8 ETO31982.1 - 0.016 15.4 0.5 0.069 13.5 0.0 1.9 2 0 0 2 2 2 0 Mouse development and cellular proliferation protein Cullin-7 RPA43_OB PF17875.1 ETO31983.1 - 0.17 12.5 4.7 0.25 11.9 4.7 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Presenilin PF01080.17 ETO31983.1 - 8.7 5.0 5.2 9.7 4.8 5.2 1.1 1 0 0 1 1 1 0 Presenilin Choline_sulf_C PF12411.8 ETO31984.1 - 0.028 14.2 0.1 0.13 12.1 0.1 2.0 2 0 0 2 2 2 0 Choline sulfatase enzyme C terminal MOR2-PAG1_C PF14225.6 ETO31986.1 - 8.2e-08 32.4 0.0 1.5e-07 31.5 0.0 1.4 1 0 0 1 1 1 1 Cell morphogenesis C-terminal WD40 PF00400.32 ETO31987.1 - 6.1e-30 102.8 23.6 7e-06 26.7 0.9 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31987.1 - 2.1e-13 50.4 0.2 0.0099 16.2 0.0 5.6 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO31987.1 - 9.5e-08 31.1 4.4 0.0022 16.7 1.0 4.2 2 2 2 4 4 4 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO31988.1 - 4.1e-37 125.5 26.0 1.5e-06 28.8 1.0 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO31988.1 - 8.4e-12 44.5 5.2 0.0023 16.7 0.0 5.2 2 2 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO31988.1 - 6.8e-09 35.9 1.1 0.013 15.8 0.0 4.6 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO31988.1 - 0.0078 15.0 10.5 1 8.0 6.5 3.7 2 1 0 2 2 2 2 Nup133 N terminal like SMC_N PF02463.19 ETO31989.1 - 0.11 11.9 0.0 0.19 11.2 0.0 1.3 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain DUF4808 PF16066.5 ETO31990.1 - 0.095 13.3 0.1 0.24 12.0 0.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4808) TipAS PF07739.13 ETO31991.1 - 0.082 13.5 0.3 0.44 11.1 0.1 2.2 2 0 0 2 2 2 0 TipAS antibiotic-recognition domain UPA_2 PF17809.1 ETO31991.1 - 0.1 12.4 0.0 0.2 11.5 0.0 1.4 1 0 0 1 1 1 0 UPA domain TPR_12 PF13424.6 ETO31993.1 - 2.7e-32 110.9 0.2 1e-13 51.3 0.1 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO31993.1 - 2.7e-24 84.3 0.4 2.1e-08 33.8 0.0 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO31993.1 - 8e-17 60.0 1.0 0.00026 20.8 0.0 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO31993.1 - 2.3e-16 58.5 10.0 0.00021 21.2 0.4 4.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO31993.1 - 3e-14 52.1 17.0 9e-05 22.1 0.6 4.3 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO31993.1 - 4.2e-14 51.5 17.3 2.1e-05 24.4 0.6 4.7 4 1 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO31993.1 - 1e-09 38.1 2.3 0.011 16.0 0.0 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO31993.1 - 2e-07 31.6 0.2 0.00095 19.8 0.0 3.3 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO31993.1 - 2.6e-07 31.0 0.4 0.0071 16.8 0.1 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO31993.1 - 1.3e-05 24.8 12.2 0.037 13.7 0.1 4.8 4 1 1 5 5 5 2 TPR repeat TPR_MalT PF17874.1 ETO31993.1 - 2.6e-05 23.8 0.0 0.15 11.4 0.0 1.9 1 1 1 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 ETO31993.1 - 2.7e-05 24.6 0.0 0.51 11.3 0.0 3.7 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO31993.1 - 5.2e-05 23.1 2.8 0.26 11.1 0.1 3.6 2 1 2 4 4 4 1 Domain of unknown function (DUF5113) PPR PF01535.20 ETO31993.1 - 0.00019 21.5 5.2 1.1 9.7 0.0 4.4 4 0 0 4 4 4 1 PPR repeat TPR_6 PF13174.6 ETO31993.1 - 0.00046 20.6 2.4 10 7.0 0.1 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_21 PF09976.9 ETO31993.1 - 0.0029 17.4 1.8 0.03 14.1 0.0 2.7 2 1 1 3 3 3 1 Tetratricopeptide repeat-like domain HTH_Bact PF18768.1 ETO31993.1 - 0.025 14.1 2.9 7.6 6.2 0.1 4.2 4 1 1 5 5 5 0 Helix-turn-helix bacterial domain Vta1_C PF18097.1 ETO31993.1 - 0.044 13.5 0.2 1.8 8.4 0.0 2.7 2 0 0 2 2 2 0 Vta1 C-terminal domain APG6 PF04111.12 ETO31993.1 - 0.049 13.6 0.2 1.3 8.9 0.1 2.1 1 1 1 2 2 2 0 Apg6 BARA domain MIT PF04212.18 ETO31993.1 - 0.085 12.9 4.1 10 6.3 0.1 3.7 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO31993.1 - 0.099 12.9 3.0 3.2 8.0 0.1 2.8 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO31993.1 - 0.12 11.9 3.3 3.4 7.2 0.1 3.8 4 1 0 4 4 4 0 SHNi-TPR Clr5 PF14420.6 ETO31993.1 - 0.16 12.3 0.9 0.29 11.4 0.9 1.5 1 0 0 1 1 1 0 Clr5 domain TPR_3 PF07720.12 ETO31993.1 - 0.63 10.1 5.6 36 4.5 0.0 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat WD40 PF00400.32 ETO31994.1 - 1.6e-35 120.5 7.7 6.7e-10 39.4 0.1 6.6 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31994.1 - 3.1e-17 62.6 0.9 0.026 14.8 0.0 7.1 2 1 5 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO31994.1 - 2.3e-11 43.2 0.7 0.0041 16.1 0.0 3.9 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO31994.1 - 0.00015 21.6 0.0 7.5 6.6 0.0 4.3 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Kelch_6 PF13964.6 ETO31994.1 - 0.00039 20.6 3.5 0.3 11.5 0.3 5.3 5 0 0 5 5 5 1 Kelch motif SGL PF08450.12 ETO31994.1 - 0.0073 15.9 0.5 0.14 11.7 0.1 2.8 2 1 1 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Kelch_4 PF13418.6 ETO31994.1 - 0.019 15.0 0.7 0.71 9.9 0.0 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO31994.1 - 0.02 14.9 4.8 0.87 9.6 0.8 4.7 6 0 0 6 6 6 0 Kelch motif Kelch_3 PF13415.6 ETO31994.1 - 0.042 14.2 2.2 14 6.1 0.0 4.0 5 0 0 5 5 5 0 Galactose oxidase, central domain DUF5570 PF17731.1 ETO31994.1 - 0.11 12.6 0.2 9.5 6.3 0.0 3.2 1 1 2 3 3 3 0 Family of unknown function (DUF5570) Kelch_1 PF01344.25 ETO31994.1 - 0.16 11.5 1.9 0.41 10.3 0.4 2.6 3 0 0 3 3 3 0 Kelch motif Proteasome_A_N PF10584.9 ETO31994.1 - 0.98 9.2 7.3 30 4.4 0.0 4.6 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO31995.1 - 3.2e-55 182.8 13.0 2.3e-09 37.7 0.7 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31995.1 - 5.8e-24 84.2 1.7 0.0013 18.9 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO31995.1 - 1.5e-11 44.5 0.1 0.00059 19.8 0.0 3.2 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO31995.1 - 4.3e-10 39.1 0.0 0.82 8.6 0.0 5.5 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO31995.1 - 1.2e-09 38.0 0.6 0.0013 18.2 0.0 3.5 1 1 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO31995.1 - 5.7e-06 25.3 1.7 1.3 7.6 0.0 4.8 2 2 3 5 5 5 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO31995.1 - 6.5e-05 23.0 1.9 5.3 7.2 0.0 4.4 2 1 3 5 5 5 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO31995.1 - 0.0002 20.0 1.8 0.33 9.4 0.3 3.3 1 1 5 6 6 6 5 Cytochrome D1 heme domain PQQ PF01011.21 ETO31995.1 - 0.00033 20.4 0.0 0.48 10.5 0.0 4.0 4 0 0 4 4 4 1 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO31995.1 - 0.011 14.6 0.2 9.5 5.0 0.0 3.6 4 1 0 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO31995.1 - 0.015 15.2 9.7 30 4.7 0.2 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat MCRS_N PF13325.6 ETO31995.1 - 0.038 14.0 0.1 0.07 13.1 0.1 1.4 1 0 0 1 1 1 0 N-terminal region of micro-spherule protein HPS6 PF15702.5 ETO31995.1 - 0.067 11.2 0.0 1.1 7.1 0.0 2.6 2 1 1 3 3 3 0 Hermansky-Pudlak syndrome 6 protein VirE1 PF12189.8 ETO31995.1 - 0.08 13.1 0.0 0.28 11.3 0.0 1.9 1 0 0 1 1 1 0 Single-strand DNA-binding protein WD40 PF00400.32 ETO31996.1 - 2.1e-10 41.0 8.6 0.011 16.5 0.2 5.3 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO31996.1 - 0.0044 17.3 0.1 0.074 13.4 0.0 2.4 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4501 PF14946.6 ETO31996.1 - 0.13 12.4 0.0 0.21 11.6 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4501) DUF1189 PF06691.11 ETO31997.1 - 0.001 18.7 0.1 0.0028 17.2 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF1189) DUF1823 PF08853.11 ETO31997.1 - 0.019 15.2 0.8 0.042 14.0 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF1823) DOCK-C2 PF14429.6 ETO31998.1 - 8.6e-22 77.9 0.4 2.3e-21 76.5 0.4 1.8 1 0 0 1 1 1 1 C2 domain in Dock180 and Zizimin proteins DOCK_N PF16172.5 ETO31998.1 - 5e-21 75.1 0.0 1.4e-20 73.5 0.0 1.7 2 0 0 2 2 2 1 DOCK N-terminus DHR-2 PF06920.13 ETO31998.1 - 1.3e-10 40.6 3.2 2.8e-08 32.9 3.6 2.9 2 1 0 2 2 2 1 Dock homology region 2 Aida_C2 PF14186.6 ETO31998.1 - 0.019 14.6 0.2 0.11 12.1 0.0 2.3 2 0 0 2 2 2 0 Cytoskeletal adhesion APG6_N PF17675.1 ETO31999.1 - 0.0032 18.0 5.9 0.014 15.9 5.9 2.1 1 0 0 1 1 1 1 Apg6 coiled-coil region DUF501 PF04417.12 ETO31999.1 - 0.11 12.3 1.7 0.83 9.5 2.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF501) DUF755 PF05501.11 ETO31999.1 - 0.53 10.6 5.4 1.8 8.8 5.4 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF755) XhlA PF10779.9 ETO31999.1 - 1.9 8.8 4.6 62 3.9 4.6 3.2 3 0 0 3 3 3 0 Haemolysin XhlA MOR2-PAG1_C PF14225.6 ETO32000.1 - 5.4e-10 39.6 0.4 2.6e-08 34.1 0.0 2.9 3 0 0 3 3 3 1 Cell morphogenesis C-terminal MOR2-PAG1_mid PF14228.6 ETO32000.1 - 7.2e-05 20.6 0.4 0.07 10.8 0.1 2.1 2 0 0 2 2 2 2 Cell morphogenesis central region PUL PF08324.11 ETO32000.1 - 0.16 11.2 3.4 0.37 10.0 3.4 1.5 1 0 0 1 1 1 0 PUL domain DUF5617 PF18493.1 ETO32004.1 - 0.00059 19.9 0.2 0.0014 18.7 0.1 1.6 1 1 0 1 1 1 1 Domain of unknown function (DUF5617) BC10 PF06726.12 ETO32005.1 - 1 9.6 0.0 1 9.6 0.0 2.3 2 0 0 2 2 2 0 Bladder cancer-related protein BC10 NS3_envE PF02723.14 ETO32005.1 - 1.9 8.6 9.2 3.5 7.8 9.2 1.4 1 0 0 1 1 1 0 Non-structural protein NS3/Small envelope protein E Orf78 PF06024.12 ETO32006.1 - 0.0058 16.9 3.3 0.0068 16.7 1.9 1.8 2 0 0 2 2 2 1 Orf78 (ac78) SNARE PF05739.19 ETO32006.1 - 0.013 15.4 4.3 0.029 14.4 4.3 1.6 1 0 0 1 1 1 0 SNARE domain ETRAMP PF09716.10 ETO32006.1 - 0.015 15.3 0.1 0.032 14.3 0.1 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) EVI2A PF05399.11 ETO32006.1 - 0.03 13.9 0.1 0.038 13.6 0.1 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Synaptobrevin PF00957.21 ETO32006.1 - 0.037 13.8 3.2 0.037 13.8 3.2 2.1 2 0 0 2 2 2 0 Synaptobrevin Plasmodium_Vir PF05795.11 ETO32006.1 - 0.038 13.4 0.2 0.047 13.1 0.2 1.3 1 0 0 1 1 1 0 Plasmodium vivax Vir protein TMEM154 PF15102.6 ETO32006.1 - 0.075 12.9 7.9 0.099 12.5 7.6 1.4 1 1 0 1 1 1 0 TMEM154 protein family RIFIN PF02009.16 ETO32006.1 - 0.25 11.2 7.7 0.19 11.6 6.1 1.5 1 1 1 2 2 2 0 Rifin Pox_EPC_I2-L1 PF12575.8 ETO32006.1 - 0.38 11.0 2.2 0.78 10.0 2.2 1.5 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 LRRC37AB_C PF14914.6 ETO32006.1 - 0.61 10.0 4.7 0.23 11.3 1.9 1.7 2 0 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain DUF5383 PF17355.2 ETO32006.1 - 0.64 10.4 4.4 0.26 11.6 0.7 2.1 3 0 0 3 3 3 0 Family of unknown function (DUF5383) RRS1 PF04939.12 ETO32007.1 - 8.9 6.1 7.2 29 4.5 2.7 2.4 1 1 1 2 2 2 0 Ribosome biogenesis regulatory protein (RRS1) GatB_Yqey PF02637.18 ETO32010.1 - 0.018 14.9 0.0 0.043 13.7 0.0 1.6 1 0 0 1 1 1 0 GatB domain PHA-1 PF06542.11 ETO32011.1 - 0.029 13.2 0.1 0.032 13.1 0.1 1.1 1 0 0 1 1 1 0 Regulator protein PHA-1 RT_RNaseH PF17917.1 ETO32012.1 - 0.38 11.1 4.6 4.6 7.6 0.5 2.4 2 0 0 2 2 2 0 RNase H-like domain found in reverse transcriptase zf-H2C2_2 PF13465.6 ETO32015.1 - 1.4e-12 47.5 23.2 2.2e-06 27.8 2.3 4.7 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETO32015.1 - 7.6e-08 32.4 30.2 0.017 15.5 2.5 4.7 4 0 0 4 4 4 4 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO32015.1 - 3.4e-06 27.4 34.3 0.017 15.9 2.4 5.2 5 0 0 5 5 5 3 C2H2-type zinc finger HypA PF01155.19 ETO32015.1 - 0.076 13.0 7.8 1.8 8.6 0.3 3.1 2 1 1 3 3 3 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA zf-C2H2_3rep PF18868.1 ETO32015.1 - 0.13 12.9 14.0 1.5 9.5 0.6 4.2 1 1 3 5 5 5 0 Zinc finger C2H2-type, 3 repeats PyrI_C PF02748.15 ETO32015.1 - 0.26 11.2 12.6 1.5 8.8 0.2 4.2 3 1 1 4 4 4 0 Aspartate carbamoyltransferase regulatory chain, metal binding domain zf-CHCC PF10276.9 ETO32015.1 - 0.43 10.7 4.0 14 5.8 0.6 2.6 2 0 0 2 2 2 0 Zinc-finger domain DUF4187 PF13821.6 ETO32015.1 - 0.84 9.5 12.8 3.6 7.4 1.9 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4187) zf-C2HE PF16278.5 ETO32015.1 - 8.5 6.9 20.5 1.8 9.1 5.7 3.9 2 2 2 4 4 4 0 C2HE / C2H2 / C2HC zinc-binding finger FAM76 PF16046.5 ETO32016.1 - 0.086 12.2 6.4 0.098 12.0 6.4 1.1 1 0 0 1 1 1 0 FAM76 protein Kelch_5 PF13854.6 ETO32017.1 - 0.025 14.6 7.2 0.27 11.3 2.3 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_2 PF07646.15 ETO32017.1 - 0.28 11.2 2.0 4.1 7.5 0.2 3.0 3 0 0 3 3 3 0 Kelch motif Ovate PF04844.13 ETO32017.1 - 0.34 10.9 1.6 3 7.9 0.0 2.7 3 0 0 3 3 3 0 Transcriptional repressor, ovate Kelch_1 PF01344.25 ETO32017.1 - 1.8 8.2 4.6 0.93 9.1 1.5 2.1 2 0 0 2 2 2 0 Kelch motif WD40 PF00400.32 ETO32018.1 - 1.3e-63 209.4 11.8 1.7e-09 38.1 0.0 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32018.1 - 2.8e-19 69.2 2.9 0.022 15.0 0.0 6.4 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32018.1 - 2.2e-11 43.7 1.8 0.00023 20.6 0.0 3.4 2 1 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO32018.1 - 1.8e-10 40.3 0.2 0.18 10.7 0.0 4.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32018.1 - 1.2e-08 34.1 2.3 0.48 9.0 0.0 4.8 1 1 4 5 5 5 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO32018.1 - 8.3e-06 25.6 1.0 20 5.3 0.0 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO32018.1 - 0.00036 20.6 1.1 2.7 8.1 0.1 4.5 1 1 4 5 5 5 1 Family of unknown function (DUF5570) DUF4221 PF13970.6 ETO32018.1 - 0.0011 18.6 1.1 1.1 8.8 0.0 3.1 1 1 2 3 3 3 2 Domain of unknown function (DUF4221) PALB2_WD40 PF16756.5 ETO32018.1 - 0.0044 16.0 4.2 0.58 9.0 0.0 4.3 1 1 4 5 5 5 1 Partner and localizer of BRCA2 WD40 domain Cytochrom_D1 PF02239.16 ETO32018.1 - 0.0045 15.6 0.5 0.82 8.1 0.1 2.3 1 1 0 2 2 2 2 Cytochrome D1 heme domain HARP PF07443.13 ETO32018.1 - 0.011 15.4 2.4 6.3 6.5 0.0 4.8 5 1 1 6 6 6 0 HepA-related protein (HARP) NHL PF01436.21 ETO32018.1 - 0.036 14.1 0.0 28 5.0 0.0 3.9 4 0 0 4 4 4 0 NHL repeat DUF5497 PF17601.2 ETO32018.1 - 0.038 14.3 0.0 0.84 10.0 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5497) DUF1258 PF06869.12 ETO32018.1 - 0.043 13.3 1.1 0.16 11.5 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1258) DUF1264 PF06884.11 ETO32018.1 - 0.061 12.9 0.4 16 5.0 0.1 3.5 3 1 1 4 4 4 0 Protein of unknown function (DUF1264) PQQ PF01011.21 ETO32018.1 - 0.063 13.2 0.0 95 3.2 0.0 4.3 4 0 0 4 4 4 0 PQQ enzyme repeat MRJP PF03022.16 ETO32018.1 - 0.17 11.2 1.8 6.5 6.0 0.0 2.8 2 1 0 2 2 2 0 Major royal jelly protein Proteasome_A_N PF10584.9 ETO32018.1 - 0.61 9.8 7.9 5.8 6.7 0.0 4.7 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature PTR2 PF00854.21 ETO32019.1 - 0.076 11.8 0.0 0.094 11.5 0.0 1.2 1 0 0 1 1 1 0 POT family WD40 PF00400.32 ETO32020.1 - 0.00058 20.6 0.5 0.18 12.7 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32020.1 - 0.032 14.5 0.0 0.059 13.7 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO32021.1 - 1e-39 133.8 14.1 1.3e-09 38.5 0.2 6.3 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32021.1 - 2.4e-07 31.0 1.9 2.8 8.3 0.0 5.0 2 1 2 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32021.1 - 0.0054 16.1 9.0 0.012 15.0 0.7 3.6 2 2 0 4 4 4 1 WD40-like domain RicinB_lectin_2 PF14200.6 ETO32022.1 - 2.5e-15 56.9 3.3 3.8e-14 53.2 1.6 2.9 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Ricin_B_lectin PF00652.22 ETO32022.1 - 0.0012 19.1 3.0 0.0013 19.0 1.3 1.8 1 1 0 1 1 1 1 Ricin-type beta-trefoil lectin domain Agglutinin PF07468.11 ETO32022.1 - 0.11 12.7 2.5 0.098 12.9 1.1 1.6 2 0 0 2 2 2 0 Agglutinin domain Hemopexin PF00045.19 ETO32024.1 - 5.7e-05 23.0 5.8 5.7e-05 23.0 5.8 2.8 3 1 0 3 3 3 1 Hemopexin PT PF04886.12 ETO32024.1 - 0.0037 16.8 9.7 0.0037 16.8 9.7 1.8 2 0 0 2 2 2 1 PT repeat Presenilin PF01080.17 ETO32025.1 - 4.4 6.0 7.8 10 4.8 7.8 1.6 1 0 0 1 1 1 0 Presenilin CagX PF03524.15 ETO32026.1 - 0.0053 16.5 2.9 0.0061 16.3 2.9 1.2 1 0 0 1 1 1 1 Conjugal transfer protein DUF4803 PF16061.5 ETO32026.1 - 0.02 14.3 7.9 0.022 14.2 7.9 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4803) DUF3340 PF11818.8 ETO32026.1 - 0.17 12.0 10.1 0.19 11.9 10.1 1.1 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) OATP PF03137.20 ETO32026.1 - 0.43 8.8 4.1 0.52 8.5 4.1 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family DUF3043 PF11241.8 ETO32026.1 - 0.82 9.7 10.0 1.2 9.2 10.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3043) Presenilin PF01080.17 ETO32026.1 - 2 7.1 4.3 1.9 7.2 4.3 1.1 1 0 0 1 1 1 0 Presenilin Connexin PF00029.19 ETO32026.1 - 3.8 7.2 7.7 4.1 7.1 7.7 1.2 1 0 0 1 1 1 0 Connexin O-antigen_lig PF13425.6 ETO32026.1 - 9.2 4.9 7.2 9.6 4.9 7.2 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein CitMHS PF03600.16 ETO32029.1 - 0.023 13.9 10.8 0.047 12.9 10.8 1.4 1 1 0 1 1 1 0 Citrate transporter TFIIF_alpha PF05793.12 ETO32029.1 - 1.2 7.7 11.5 1.6 7.3 11.5 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) RNase_H PF00075.24 ETO32030.1 - 1.4e-11 44.7 0.0 3e-11 43.7 0.0 1.5 1 0 0 1 1 1 1 RNase H RVT_3 PF13456.6 ETO32030.1 - 0.0002 21.2 0.0 0.033 14.0 0.0 2.3 2 0 0 2 2 2 2 Reverse transcriptase-like BBP1_C PF15272.6 ETO32032.1 - 0.091 12.6 0.6 0.13 12.1 0.6 1.2 1 0 0 1 1 1 0 Spindle pole body component BBP1, C-terminal G-alpha PF00503.20 ETO32033.1 - 1.5e-81 274.3 2.6 1.9e-81 274.0 2.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO32033.1 - 1.4e-10 40.9 1.2 2e-07 30.6 0.1 3.0 2 2 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO32033.1 - 0.0025 17.2 0.4 0.4 10.0 0.0 2.6 2 0 0 2 2 2 1 Gtr1/RagA G protein conserved region AAA_16 PF13191.6 ETO32033.1 - 0.0048 17.3 0.0 0.0077 16.6 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Roc PF08477.13 ETO32033.1 - 0.0063 16.7 0.1 1.5 9.1 0.1 2.4 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase SMC_N PF02463.19 ETO32033.1 - 0.014 14.8 0.1 0.024 14.1 0.1 1.4 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ETO32033.1 - 0.021 14.9 0.0 8.3 6.5 0.0 2.6 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_21 PF13304.6 ETO32033.1 - 0.028 14.3 0.1 0.056 13.2 0.1 1.6 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system ABC_tran PF00005.27 ETO32033.1 - 0.033 14.7 0.3 0.064 13.8 0.3 1.5 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ETO32033.1 - 0.037 13.8 0.0 0.087 12.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_33 PF13671.6 ETO32033.1 - 0.059 13.5 0.0 0.35 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain Mg_chelatase PF01078.21 ETO32033.1 - 0.059 12.7 0.0 0.13 11.7 0.0 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 ETO32033.1 - 0.066 12.6 0.0 0.13 11.6 0.0 1.4 1 0 0 1 1 1 0 FtsK/SpoIIIE family RsgA_GTPase PF03193.16 ETO32033.1 - 0.15 11.9 0.0 5.3 6.9 0.0 2.3 2 0 0 2 2 2 0 RsgA GTPase SBDS PF01172.18 ETO32034.1 - 2.8e-18 65.8 0.1 3.6e-18 65.4 0.1 1.2 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein Castor_Poll_mid PF06241.12 ETO32034.1 - 0.047 13.7 0.1 6.7 6.7 0.0 2.1 1 1 1 2 2 2 0 Castor and Pollux, part of voltage-gated ion channel AIG1 PF04548.16 ETO32035.1 - 4.1e-05 23.0 0.3 0.00028 20.3 0.1 2.4 1 1 0 1 1 1 1 AIG1 family Septin PF00735.18 ETO32035.1 - 0.0005 19.4 0.1 0.0012 18.1 0.1 1.7 1 0 0 1 1 1 1 Septin T2SSE PF00437.20 ETO32035.1 - 0.005 15.9 0.8 0.022 13.8 0.1 2.2 2 1 0 2 2 2 1 Type II/IV secretion system protein ABC_tran PF00005.27 ETO32035.1 - 0.0072 16.8 0.7 0.021 15.3 0.1 2.2 2 0 0 2 2 2 1 ABC transporter DUF4600 PF15372.6 ETO32035.1 - 0.017 15.5 0.1 0.017 15.5 0.1 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4600) V-SNARE PF05008.15 ETO32035.1 - 0.036 14.4 1.4 0.29 11.5 0.2 2.9 2 0 0 2 2 2 0 Vesicle transport v-SNARE protein N-terminus CLZ PF16526.5 ETO32035.1 - 0.041 14.2 0.5 0.041 14.2 0.5 3.1 4 0 0 4 4 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF5082 PF16888.5 ETO32035.1 - 0.05 13.9 0.6 0.05 13.9 0.6 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5082) AAA PF00004.29 ETO32035.1 - 0.06 13.8 0.1 3.4 8.1 0.0 3.4 2 1 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) TsaE PF02367.17 ETO32035.1 - 0.095 12.7 0.0 0.26 11.3 0.0 1.7 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Med9 PF07544.13 ETO32035.1 - 0.11 12.6 5.1 3.8 7.7 0.2 2.9 2 0 0 2 2 2 0 RNA polymerase II transcription mediator complex subunit 9 Matrilin_ccoil PF10393.9 ETO32035.1 - 1.3 8.9 7.9 2.9 7.8 0.9 3.0 2 0 0 2 2 2 0 Trimeric coiled-coil oligomerisation domain of matrilin GCN5L1 PF06320.13 ETO32035.1 - 6.7 6.9 7.7 0.28 11.3 0.2 2.6 3 0 0 3 3 3 0 GCN5-like protein 1 (GCN5L1) DUF1284 PF06935.11 ETO32035.1 - 6.7 7.2 12.8 0.26 11.8 0.2 4.0 5 0 0 5 5 4 0 Protein of unknown function (DUF1284) ABC_tran PF00005.27 ETO32037.1 - 7.7e-08 32.9 0.1 7.7e-08 32.9 0.1 1.9 2 1 0 2 2 2 1 ABC transporter RsgA_GTPase PF03193.16 ETO32037.1 - 0.012 15.5 0.1 0.021 14.7 0.1 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ETO32037.1 - 0.069 12.9 0.5 0.14 11.9 0.5 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AFT PF08731.11 ETO32037.1 - 0.094 13.1 4.6 0.14 12.5 4.6 1.2 1 0 0 1 1 1 0 Transcription factor AFT EBV-NA3 PF05009.12 ETO32038.1 - 0.67 9.4 3.9 3 7.3 1.7 2.3 2 0 0 2 2 2 0 Epstein-Barr virus nuclear antigen 3 (EBNA-3) LRR_4 PF12799.7 ETO32039.1 - 4.5e-07 30.1 34.4 0.036 14.5 0.7 6.3 6 1 0 6 6 6 4 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO32039.1 - 1.9e-06 27.5 34.0 2.7e-05 23.8 4.4 5.8 4 2 3 7 7 7 2 Leucine rich repeat LRR_1 PF00560.33 ETO32039.1 - 0.87 10.4 23.8 1.3 9.9 0.0 8.3 8 1 0 8 8 8 0 Leucine Rich Repeat LRR_6 PF13516.6 ETO32039.1 - 5.1 7.4 14.8 9.5 6.6 0.8 4.8 4 0 0 4 4 4 0 Leucine Rich repeat WD40 PF00400.32 ETO32040.1 - 1.3e-35 120.8 29.0 4.3e-06 27.4 2.1 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32040.1 - 1.9e-08 34.5 2.6 1.7 9.0 0.0 5.9 3 1 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32040.1 - 9e-06 24.6 4.3 0.23 10.0 0.3 4.2 1 1 2 4 4 4 3 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO32040.1 - 0.056 13.3 3.2 3 7.7 0.1 3.3 4 0 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain PsbL PF02419.17 ETO32043.1 - 0.9 9.6 0.0 0.9 9.6 0.0 3.2 4 0 0 4 4 4 0 PsbL protein zf-PHD-like PF15446.6 ETO32044.1 - 0.003 17.2 1.2 0.005 16.5 1.2 1.4 1 0 0 1 1 1 1 PHD/FYVE-zinc-finger like domain Zf_RING PF16744.5 ETO32044.1 - 0.015 15.4 1.1 0.023 14.8 0.2 1.8 2 0 0 2 2 2 0 KIAA1045 RING finger zf-C2H2_4 PF13894.6 ETO32044.1 - 0.065 14.1 4.7 1.2 10.2 0.3 2.7 2 0 0 2 2 2 0 C2H2-type zinc finger zf-C2HC_2 PF13913.6 ETO32044.1 - 0.08 12.9 0.1 0.08 12.9 0.1 1.8 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-C2H2 PF00096.26 ETO32044.1 - 0.34 11.4 0.3 0.34 11.4 0.3 2.4 2 0 0 2 2 2 0 Zinc finger, C2H2 type Bystin PF05291.11 ETO32046.1 - 8.2e-84 281.3 5.8 2.1e-54 184.8 1.2 2.4 2 0 0 2 2 2 2 Bystin EcKinase PF02958.20 ETO32048.1 - 0.005 16.2 0.2 0.0072 15.7 0.1 1.5 1 1 0 1 1 1 1 Ecdysteroid kinase RPW8 PF05659.11 ETO32048.1 - 0.071 12.8 0.3 0.071 12.8 0.3 2.1 2 0 0 2 2 2 0 Arabidopsis broad-spectrum mildew resistance protein RPW8 OSCP PF00213.18 ETO32048.1 - 0.26 11.4 4.4 0.12 12.4 0.4 2.1 1 1 1 2 2 2 0 ATP synthase delta (OSCP) subunit His_Phos_2 PF00328.22 ETO32049.1 - 9.1e-11 41.7 0.0 1.3e-10 41.2 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 2) DUF1295 PF06966.12 ETO32050.1 - 2.8e-31 108.8 17.2 2.8e-31 108.8 17.2 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ETO32050.1 - 0.0098 16.3 1.0 0.029 14.8 0.1 2.2 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO32050.1 - 0.04 14.3 3.3 0.049 14.0 0.5 2.6 2 1 1 3 3 3 0 Phospholipid methyltransferase Kinesin PF00225.23 ETO32051.1 - 8.5e-93 310.9 0.4 9.9e-50 169.3 0.8 3.3 2 2 1 3 3 3 2 Kinesin motor domain Microtub_bd PF16796.5 ETO32051.1 - 2.5e-28 98.9 0.0 2.5e-28 98.9 0.0 2.6 2 1 0 2 2 2 1 Microtubule binding DUF4349 PF14257.6 ETO32051.1 - 2.1 7.7 9.1 6.9 6.1 2.8 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) DUF3372 PF11852.8 ETO32053.1 - 7.8e-06 25.5 2.0 1.5e-05 24.5 2.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF3372) RCC1 PF00415.18 ETO32053.1 - 0.0024 18.4 0.0 2.2 9.0 0.0 2.4 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat C1_2 PF03107.16 ETO32053.1 - 0.18 12.1 0.9 0.5 10.7 0.9 1.7 1 0 0 1 1 1 0 C1 domain DUF148 PF02520.17 ETO32055.1 - 0.008 16.3 1.0 0.024 14.8 0.6 1.9 2 0 0 2 2 2 1 Domain of unknown function DUF148 CNDH2_M PF16869.5 ETO32055.1 - 0.27 11.9 3.5 0.53 11.0 3.5 1.4 1 0 0 1 1 1 0 PF16858 PRAP PF15314.6 ETO32055.1 - 0.48 10.9 3.4 1.5 9.4 0.0 3.2 3 1 0 3 3 3 0 Proline-rich acidic protein 1, pregnancy-specific uterine DUF2011 PF09428.10 ETO32056.1 - 0.096 12.9 0.5 0.17 12.1 0.5 1.5 1 0 0 1 1 1 0 Fungal protein of unknown function (DUF2011) BTB_2 PF02214.22 ETO32057.1 - 9.2e-06 25.9 0.3 0.00013 22.3 0.1 2.3 2 0 0 2 2 2 1 BTB/POZ domain Peptidase_C14 PF00656.22 ETO32058.1 - 4.1e-09 36.8 2.3 2e-08 34.5 2.3 2.1 1 1 0 1 1 1 1 Caspase domain DUF5387 PF17361.2 ETO32058.1 - 0.053 13.2 1.4 0.18 11.4 0.0 2.3 2 0 0 2 2 2 0 Family of unknown function (DUF5387) RdDM_RDM1 PF09187.10 ETO32058.1 - 0.1 12.7 0.3 0.23 11.6 0.3 1.6 1 0 0 1 1 1 0 RNA-directed DNA methylation 1 Kelch_2 PF07646.15 ETO32058.1 - 0.28 11.2 0.9 14 5.8 0.0 3.3 3 0 0 3 3 3 0 Kelch motif ZapB PF06005.12 ETO32060.1 - 0.0064 16.9 6.9 0.0064 16.9 6.9 5.3 4 1 1 5 5 5 1 Cell division protein ZapB COG5 PF10392.9 ETO32060.1 - 0.012 15.8 5.0 0.012 15.8 5.0 3.9 3 1 1 4 4 4 0 Golgi transport complex subunit 5 CEP63 PF17045.5 ETO32060.1 - 0.12 12.2 53.2 1.9 8.3 28.7 3.6 1 1 2 3 3 3 0 Centrosomal protein of 63 kDa Spc7 PF08317.11 ETO32060.1 - 0.16 10.9 44.4 0.028 13.3 8.3 2.4 1 1 0 2 2 2 0 Spc7 kinetochore protein Rootletin PF15035.6 ETO32060.1 - 3 7.8 44.9 0.27 11.2 12.1 2.8 1 1 1 3 3 3 0 Ciliary rootlet component, centrosome cohesion Bcr-Abl_Oligo PF09036.10 ETO32060.1 - 3.4 7.7 12.3 0.1 12.6 2.9 3.1 3 1 0 3 3 3 0 Bcr-Abl oncoprotein oligomerisation domain DUF1664 PF07889.12 ETO32060.1 - 8.1 6.5 25.0 3.4 7.7 0.8 4.2 2 2 4 6 6 6 0 Protein of unknown function (DUF1664) V_ATPase_I PF01496.19 ETO32063.1 - 5.3 4.8 7.1 0.38 8.6 0.3 2.0 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family EphA2_TM PF14575.6 ETO32063.1 - 5.6 7.9 10.9 0.57 11.1 1.6 3.1 2 1 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain DUF4288 PF14119.6 ETO32064.1 - 0.14 12.6 2.5 0.2 12.1 2.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4288) MDM10 PF12519.8 ETO32064.1 - 7 5.4 10.3 8.4 5.1 10.3 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 RICTOR_M PF14666.6 ETO32065.1 - 0.0083 15.9 3.5 0.67 9.8 0.1 3.0 4 0 0 4 4 4 2 Rapamycin-insensitive companion of mTOR, middle domain zinc-ribbon_6 PF10005.9 ETO32065.1 - 0.46 11.2 4.4 3.5 8.4 1.1 2.5 2 0 0 2 2 2 0 zinc-ribbon domain L_lac_phage_MSP PF06488.11 ETO32066.1 - 0.014 14.7 0.0 0.02 14.2 0.0 1.2 1 0 0 1 1 1 0 Phage tail tube protein CAP_GLY PF01302.25 ETO32066.1 - 0.17 11.9 0.1 0.4 10.7 0.1 1.6 1 0 0 1 1 1 0 CAP-Gly domain FlaC_arch PF05377.11 ETO32067.1 - 0.0069 16.8 0.6 0.0069 16.8 0.6 4.1 4 0 0 4 4 4 2 Flagella accessory protein C (FlaC) DUF1664 PF07889.12 ETO32067.1 - 0.43 10.6 15.1 1.3 9.1 0.3 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) FGGY_C PF02782.16 ETO32070.1 - 2e-40 138.6 0.0 2.9e-40 138.1 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ETO32070.1 - 1.1e-11 44.8 0.0 2.9e-11 43.4 0.0 1.7 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain FUN14 PF04930.15 ETO32070.1 - 0.089 13.2 0.2 2.4 8.6 0.2 2.6 1 1 0 1 1 1 0 FUN14 family UCH PF00443.29 ETO32071.1 - 1.4e-28 100.2 1.5 2.6e-28 99.2 0.0 2.3 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF3408 PF11888.8 ETO32071.1 - 0.0089 16.2 0.7 0.0089 16.2 0.7 3.2 3 0 0 3 3 3 1 Protein of unknown function (DUF3408) UCH_1 PF13423.6 ETO32071.1 - 0.33 10.5 9.1 3 7.3 0.0 3.4 3 1 0 3 3 3 0 Ubiquitin carboxyl-terminal hydrolase Nucleo_P87 PF07267.11 ETO32071.1 - 0.42 9.4 14.4 0.83 8.4 14.4 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 FancD2 PF14631.6 ETO32071.1 - 1.5 6.1 7.6 2.5 5.4 7.6 1.3 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease Band_3_cyto PF07565.13 ETO32071.1 - 7.2 6.3 7.5 2.5 7.8 3.7 2.2 2 0 0 2 2 2 0 Band 3 cytoplasmic domain zf-4CXXC_R1 PF10497.9 ETO32073.1 - 0.00011 22.4 20.4 0.0034 17.6 20.4 2.3 1 1 0 1 1 1 1 Zinc-finger domain of monoamine-oxidase A repressor R1 CENP-B_dimeris PF09026.10 ETO32074.1 - 0.015 15.6 0.9 2.3 8.7 0.4 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain PHD_3 PF13922.6 ETO32074.1 - 0.029 14.7 7.5 0.091 13.2 1.0 2.9 3 0 0 3 3 3 0 PHD domain of transcriptional enhancer, Asx Phage_G PF02306.15 ETO32074.1 - 0.065 13.0 0.1 0.098 12.4 0.1 1.2 1 0 0 1 1 1 0 Major spike protein (G protein) DNA_ligase_ZBD PF03119.16 ETO32074.1 - 1.1 9.4 0.0 1.1 9.4 0.0 2.9 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain Metallophos PF00149.28 ETO32075.1 - 1.6e-08 35.3 0.9 6.3e-08 33.4 0.1 2.1 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase AOX PF01786.17 ETO32075.1 - 0.01 15.5 0.1 0.98 9.0 0.2 2.3 2 0 0 2 2 2 0 Alternative oxidase CEBP_ZZ PF16366.5 ETO32075.1 - 0.57 10.5 8.4 0.29 11.4 0.4 3.0 2 0 0 2 2 2 0 Cytoplasmic polyadenylation element-binding protein ZZ domain CH PF00307.31 ETO32076.1 - 5.1e-30 103.9 0.4 1.8e-13 50.6 0.0 6.0 5 1 0 5 5 5 4 Calponin homology (CH) domain CAMSAP_CH PF11971.8 ETO32076.1 - 0.0029 17.4 0.0 0.14 12.0 0.0 2.9 2 0 0 2 2 2 1 CAMSAP CH domain CHASE3 PF05227.13 ETO32076.1 - 1.8 8.5 7.6 0.89 9.5 0.6 2.5 2 0 0 2 2 2 0 CHASE3 domain Pkinase PF00069.25 ETO32077.1 - 8.9e-46 156.4 0.0 1.1e-45 156.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32077.1 - 2.2e-16 59.9 0.0 4.3e-16 59.0 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Alpha-mann_mid PF09261.11 ETO32078.1 - 6.6e-14 51.8 0.0 1.4e-13 50.8 0.0 1.5 1 0 0 1 1 1 1 Alpha mannosidase middle domain Glyco_hydro_38N PF01074.22 ETO32078.1 - 4e-13 49.4 0.2 5.6e-13 48.9 0.2 1.2 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 N-terminal domain APG17 PF04108.12 ETO32079.1 - 5.1e-07 29.1 0.0 5.1e-07 29.1 0.0 2.2 3 0 0 3 3 3 1 Autophagy protein Apg17 DUF2381 PF09544.10 ETO32079.1 - 0.17 11.4 1.4 2 7.9 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2381) DUF4337 PF14235.6 ETO32079.1 - 0.73 9.9 3.8 1.3 9.1 3.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) fn3 PF00041.21 ETO32080.1 - 8.5e-12 45.3 3.1 9.2e-07 29.1 0.7 3.1 2 1 0 2 2 2 2 Fibronectin type III domain DUF2369 PF10179.9 ETO32080.1 - 0.00036 20.9 0.3 0.0064 16.8 0.0 2.7 3 0 0 3 3 3 1 Uncharacterised conserved protein (DUF2369) Pur_ac_phosph_N PF16656.5 ETO32080.1 - 0.051 14.2 2.7 9.9 6.8 0.0 3.1 2 2 1 3 3 3 0 Purple acid Phosphatase, N-terminal domain Interfer-bind PF09294.10 ETO32080.1 - 0.79 10.1 5.7 3.3 8.1 0.2 3.2 4 0 0 4 4 4 0 Interferon-alpha/beta receptor, fibronectin type III Dynactin_p22 PF07426.11 ETO32081.1 - 1.4e-14 54.3 7.5 2.2e-14 53.6 7.5 1.2 1 0 0 1 1 1 1 Dynactin subunit p22 ABC_tran_CTD PF16326.5 ETO32081.1 - 0.00021 21.5 2.2 0.00021 21.5 2.2 2.4 1 1 1 2 2 2 1 ABC transporter C-terminal domain DASH_Dad2 PF08654.10 ETO32081.1 - 0.018 15.4 0.0 0.062 13.7 0.0 1.8 1 0 0 1 1 1 0 DASH complex subunit Dad2 LOH1CR12 PF10158.9 ETO32081.1 - 0.018 15.0 1.4 0.05 13.6 1.4 1.7 1 0 0 1 1 1 0 Tumour suppressor protein DUF5344 PF17279.2 ETO32081.1 - 0.027 15.0 2.8 0.027 15.0 2.8 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5344) DUF4200 PF13863.6 ETO32081.1 - 0.061 13.7 9.1 0.17 12.3 9.1 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) CCDC-167 PF15188.6 ETO32081.1 - 0.11 12.9 6.1 0.44 10.9 6.1 2.0 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 167 NPV_P10 PF05531.12 ETO32081.1 - 0.13 12.7 0.5 0.13 12.7 0.5 2.3 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein BMFP PF04380.13 ETO32081.1 - 0.22 12.0 5.1 0.84 10.2 5.1 2.0 1 1 0 1 1 1 0 Membrane fusogenic activity Sec34 PF04136.15 ETO32081.1 - 0.24 11.3 8.3 0.067 13.1 4.1 2.1 2 1 0 2 2 2 0 Sec34-like family M11L PF11099.8 ETO32082.1 - 0.04 14.2 0.7 1.7 8.9 0.0 2.2 2 0 0 2 2 2 0 Apoptosis regulator M11L like WD40 PF00400.32 ETO32083.1 - 8.5e-134 431.5 60.1 1e-09 38.8 0.1 14.8 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32083.1 - 1.1e-52 176.3 5.7 8e-05 22.9 0.0 13.6 1 1 12 13 13 13 12 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32083.1 - 1.6e-27 96.7 6.8 0.0015 17.9 0.0 8.5 1 1 5 7 7 7 6 WD40-like domain Ge1_WD40 PF16529.5 ETO32083.1 - 5.7e-17 61.7 13.3 0.46 9.4 0.5 11.7 2 1 9 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32083.1 - 5.1e-14 51.8 14.6 0.26 9.9 0.0 9.2 2 2 7 9 9 9 6 Nucleoporin Nup120/160 NACHT PF05729.12 ETO32083.1 - 1.1e-08 35.2 0.0 2.1e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain PD40 PF07676.12 ETO32083.1 - 1.1e-08 34.8 10.2 17 5.5 0.0 11.1 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO32083.1 - 5.6e-06 26.4 11.3 16 5.6 0.1 9.8 6 4 1 8 8 8 0 Ciliary BBSome complex subunit 2, middle region Pentapeptide PF00805.22 ETO32083.1 - 5e-05 22.8 1.2 0.00015 21.3 1.3 1.8 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) Gmad1 PF10647.9 ETO32083.1 - 5.5e-05 23.0 0.7 0.76 9.5 0.1 5.3 2 2 1 4 4 4 1 Lipoprotein LpqB beta-propeller domain DUF5570 PF17731.1 ETO32083.1 - 0.001 19.2 21.5 0.93 9.6 0.1 8.9 2 2 5 9 9 9 1 Family of unknown function (DUF5570) TolB_N PF04052.13 ETO32083.1 - 0.0084 16.3 0.2 1.2e+02 2.9 0.0 6.3 8 0 0 8 8 7 0 TolB amino-terminal domain HARP PF07443.13 ETO32083.1 - 0.029 14.0 0.0 23 4.7 0.0 3.8 3 0 0 3 3 3 0 HepA-related protein (HARP) Pentapeptide_4 PF13599.6 ETO32083.1 - 0.035 14.3 0.1 0.11 12.7 0.1 1.9 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO32083.1 - 0.16 12.2 0.9 2.3 8.5 0.9 2.8 1 1 0 1 1 1 0 AAA domain GCV_T_C PF08669.11 ETO32083.1 - 0.29 11.1 4.4 35 4.4 0.0 4.9 6 0 0 6 6 6 0 Glycine cleavage T-protein C-terminal barrel domain DDE_3 PF13358.6 ETO32084.1 - 1.2e-21 77.0 0.2 1.2e-21 77.0 0.2 1.7 2 0 0 2 2 2 1 DDE superfamily endonuclease HTH_Tnp_Tc3_2 PF01498.18 ETO32084.1 - 1.4e-12 47.7 6.1 1.4e-12 47.7 6.1 2.2 2 0 0 2 2 2 1 Transposase ATG27 PF09451.10 ETO32085.1 - 1.3e-05 25.2 1.2 2.9e-05 24.1 1.1 1.7 1 1 0 1 1 1 1 Autophagy-related protein 27 Man-6-P_recep PF02157.15 ETO32085.1 - 0.0023 17.1 1.1 0.0039 16.3 0.0 1.8 2 0 0 2 2 2 1 Mannose-6-phosphate receptor GAPT PF11770.8 ETO32085.1 - 0.16 11.8 0.5 0.31 10.9 0.5 1.4 1 0 0 1 1 1 0 GRB2-binding adapter (GAPT) MARVEL PF01284.23 ETO32085.1 - 0.29 11.1 2.6 0.76 9.8 0.2 2.4 2 1 0 3 3 3 0 Membrane-associating domain Orthoreo_P10 PF07204.11 ETO32085.1 - 0.45 10.5 4.6 0.17 11.9 1.3 2.1 2 1 0 2 2 2 0 Orthoreovirus membrane fusion protein p10 Colipase_C PF02740.14 ETO32085.1 - 3.8 7.8 9.2 3.3 8.0 4.2 2.4 2 0 0 2 2 2 0 Colipase, C-terminal domain UCH PF00443.29 ETO32088.1 - 1.9e-13 50.5 0.1 5.1e-13 49.1 0.0 1.6 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Kelch_5 PF13854.6 ETO32089.1 - 6.5e-06 26.0 0.5 1.1 9.3 0.1 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO32089.1 - 2.1e-05 24.6 1.9 0.048 14.0 0.1 3.8 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO32089.1 - 0.0024 17.4 1.4 0.74 9.4 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO32089.1 - 0.0034 17.6 4.8 0.031 14.6 0.0 4.2 6 0 0 6 6 6 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO32089.1 - 0.0038 17.2 1.9 0.046 13.7 0.0 3.4 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO32089.1 - 0.027 14.5 1.2 5 7.3 0.0 4.2 5 0 0 5 5 5 0 Kelch motif EAF PF09816.9 ETO32089.1 - 0.087 13.2 0.1 0.98 9.9 0.0 2.3 2 0 0 2 2 2 0 RNA polymerase II transcription elongation factor Apc13p PF05839.11 ETO32089.1 - 0.17 12.1 0.1 0.17 12.1 0.1 1.9 2 0 0 2 2 2 0 Apc13p protein EF-hand_1 PF00036.32 ETO32090.1 - 2.2e-23 80.0 9.5 6e-09 34.8 0.2 4.5 4 0 0 4 4 4 3 EF hand EF-hand_7 PF13499.6 ETO32090.1 - 1.4e-21 76.7 5.0 8.1e-12 45.4 0.7 2.2 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO32090.1 - 1.9e-21 74.1 5.8 1.4e-08 34.0 0.1 4.5 4 0 0 4 4 4 3 EF-hand domain EF-hand_8 PF13833.6 ETO32090.1 - 1e-16 60.5 9.2 2.5e-06 27.2 0.3 4.1 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_9 PF14658.6 ETO32090.1 - 4.8e-14 52.4 0.1 2.8e-07 30.8 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_5 PF13202.6 ETO32090.1 - 1.8e-09 36.7 12.9 7.3e-05 22.1 0.2 4.5 5 0 0 5 5 5 3 EF hand Caleosin PF05042.13 ETO32090.1 - 0.00017 21.6 0.6 2 8.3 0.0 3.7 1 1 3 4 4 4 1 Caleosin related protein EF-hand_4 PF12763.7 ETO32090.1 - 0.00044 20.1 2.1 0.91 9.5 1.5 2.5 2 1 0 2 2 2 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 ETO32090.1 - 0.0061 16.9 0.8 2.3 8.7 0.1 3.1 2 2 0 2 2 2 1 EF-hand domain Toprim_2 PF13155.6 ETO32090.1 - 0.014 15.8 2.8 2.6 8.5 0.3 3.0 1 1 1 2 2 2 0 Toprim-like EAP30 PF04157.16 ETO32090.1 - 0.018 14.3 1.9 2.3 7.5 0.0 2.3 1 1 1 2 2 2 0 EAP30/Vps36 family TRCF PF03461.15 ETO32090.1 - 0.02 15.2 0.7 0.25 11.7 0.2 2.3 1 1 1 2 2 2 0 TRCF domain Gp-FAR-1 PF05823.12 ETO32090.1 - 0.021 15.2 3.2 0.057 13.8 0.1 2.6 1 1 1 3 3 3 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) PH PF00169.29 ETO32091.1 - 0.00018 22.0 14.1 0.015 15.8 0.2 3.8 3 1 1 4 4 4 2 PH domain Connexin PF00029.19 ETO32091.1 - 1.1 8.9 6.8 3.6 7.3 0.2 2.9 2 0 0 2 2 2 0 Connexin CPP1-like PF11833.8 ETO32091.1 - 3.4 7.3 5.6 1.4 8.6 2.4 1.9 2 0 0 2 2 2 0 Protein CHAPERONE-LIKE PROTEIN OF POR1-like CiPC PF15800.5 ETO32092.1 - 4.4e-05 23.4 0.9 4.4e-05 23.4 0.9 2.2 2 0 0 2 2 2 1 Clock interacting protein circadian NAF PF03822.14 ETO32092.1 - 0.00065 19.8 0.5 0.0015 18.6 0.0 1.9 2 0 0 2 2 2 1 NAF domain BSP_II PF05432.11 ETO32093.1 - 0.0088 15.8 28.5 0.014 15.1 28.5 1.3 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) Pkinase PF00069.25 ETO32093.1 - 0.014 14.8 0.0 0.028 13.8 0.0 1.5 1 0 0 1 1 1 0 Protein kinase domain DUF3915 PF13054.6 ETO32093.1 - 0.1 12.6 0.3 0.1 12.6 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) Nop14 PF04147.12 ETO32093.1 - 0.17 10.1 23.6 0.21 9.7 23.6 1.3 1 0 0 1 1 1 0 Nop14-like family PI3K_1B_p101 PF10486.9 ETO32093.1 - 0.75 7.5 17.2 0.44 8.3 15.5 1.4 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit NOA36 PF06524.12 ETO32093.1 - 1.7 7.9 19.7 0.45 9.8 15.8 1.9 2 0 0 2 2 2 0 NOA36 protein GREB1 PF15782.5 ETO32093.1 - 2.9 4.9 14.0 3.4 4.7 14.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Usp PF00582.26 ETO32093.1 - 6.8 7.2 9.2 22 5.6 3.8 2.4 2 0 0 2 2 2 0 Universal stress protein family Microtub_bd PF16796.5 ETO32094.1 - 4.8e-11 42.8 5.8 4.8e-11 42.8 5.8 2.6 1 1 1 2 2 2 1 Microtubule binding THOC7 PF05615.13 ETO32094.1 - 0.0093 16.2 1.9 0.0093 16.2 1.9 2.3 3 0 0 3 3 3 1 Tho complex subunit 7 NuiA PF07924.11 ETO32094.1 - 6.6 7.2 8.6 0.74 10.2 0.8 2.8 2 1 1 3 3 3 0 Nuclease A inhibitor-like protein DUF4834 PF16118.5 ETO32096.1 - 0.06 14.3 0.1 0.06 14.3 0.1 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) DUF2884 PF11101.8 ETO32098.1 - 0.031 13.8 0.5 0.046 13.2 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2884) DUF3948 PF13134.6 ETO32100.1 - 0.1 12.3 0.0 0.19 11.4 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3948) PDEase_I PF00233.19 ETO32101.1 - 1.1e-37 130.1 0.0 1.5e-37 129.6 0.0 1.2 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase Sigma70_ner PF04546.13 ETO32101.1 - 0.45 10.4 1.9 0.59 10.0 1.9 1.1 1 0 0 1 1 1 0 Sigma-70, non-essential region LSR PF05624.14 ETO32102.1 - 0.26 11.3 3.0 0.24 11.4 0.8 2.2 2 0 0 2 2 2 0 Lipolysis stimulated receptor (LSR) WD40 PF00400.32 ETO32103.1 - 0.0045 17.8 0.4 0.87 10.6 0.0 2.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Copper-fist PF00649.18 ETO32103.1 - 0.035 13.6 0.0 3.5 7.2 0.0 2.5 2 0 0 2 2 2 0 Copper fist DNA binding domain DUF2407 PF10302.9 ETO32103.1 - 0.067 13.8 0.4 1.3 9.7 0.3 2.3 1 1 0 1 1 1 0 DUF2407 ubiquitin-like domain DUF3316 PF11777.8 ETO32103.1 - 0.098 12.7 1.7 0.14 12.3 0.6 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF3316) Ribosomal_L2_C PF03947.18 ETO32104.1 - 1.1e-43 148.4 6.2 1.6e-43 147.9 6.2 1.2 1 0 0 1 1 1 1 Ribosomal Proteins L2, C-terminal domain LMBR1 PF04791.16 ETO32105.1 - 3.7e-11 42.6 0.0 4.4e-11 42.4 0.0 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein AA_permease_C PF13906.6 ETO32105.1 - 0.03 14.4 3.2 0.03 14.4 3.2 1.6 2 0 0 2 2 2 0 C-terminus of AA_permease ATP11 PF06644.11 ETO32106.1 - 0.12 12.1 0.1 0.12 12.1 0.1 3.8 1 1 2 3 3 3 0 ATP11 protein IGFL PF14653.6 ETO32108.1 - 0.1 12.6 0.3 0.22 11.5 0.3 1.5 1 0 0 1 1 1 0 Insulin growth factor-like family Lipase_GDSL_2 PF13472.6 ETO32109.1 - 1.6e-05 25.3 0.0 2.2e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Lipase_GDSL PF00657.22 ETO32109.1 - 0.00043 20.3 0.1 0.00064 19.7 0.1 1.3 1 1 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase CRAL_TRIO_2 PF13716.6 ETO32109.1 - 0.095 12.9 0.0 0.12 12.5 0.0 1.4 1 0 0 1 1 1 0 Divergent CRAL/TRIO domain Synuclein PF01387.17 ETO32110.1 - 0.17 12.1 0.1 0.26 11.5 0.1 1.5 1 1 0 1 1 1 0 Synuclein EOS1 PF12326.8 ETO32111.1 - 0.059 13.3 0.8 0.075 13.0 0.3 1.6 2 0 0 2 2 2 0 N-glycosylation protein CENP-B_dimeris PF09026.10 ETO32112.1 - 0.019 15.3 2.6 0.036 14.5 2.6 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain PIP49_N PF14875.6 ETO32112.1 - 0.12 12.3 1.2 0.21 11.5 1.2 1.4 1 0 0 1 1 1 0 N-term cysteine-rich ER, FAM69 Hus1 PF04005.12 ETO32114.1 - 0.045 12.9 0.3 0.061 12.4 0.3 1.1 1 0 0 1 1 1 0 Hus1-like protein DUF5624 PF18538.1 ETO32117.1 - 1.2 9.2 3.8 5.3 7.2 0.6 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF5624) WD40 PF00400.32 ETO32118.1 - 7e-42 140.6 29.8 1.1e-07 32.4 0.5 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32118.1 - 1.8e-16 60.2 1.2 0.12 12.7 0.0 6.6 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32118.1 - 6.1e-12 45.0 5.1 0.046 12.4 0.0 5.3 3 1 2 5 5 5 5 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO32118.1 - 0.011 15.8 0.4 0.3 11.2 0.1 3.4 4 0 0 4 4 4 0 Ciliary BBSome complex subunit 2, middle region CobU PF02283.16 ETO32118.1 - 1.8 8.1 7.0 3.8 7.1 7.0 1.4 1 0 0 1 1 1 0 Cobinamide kinase / cobinamide phosphate guanyltransferase WD40 PF00400.32 ETO32119.1 - 1.9e-39 132.9 30.7 2.5e-07 31.3 2.1 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32119.1 - 2.7e-12 46.8 2.0 0.13 12.6 0.0 6.2 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32119.1 - 2e-08 33.3 17.0 0.0033 16.1 1.9 5.7 2 1 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32119.1 - 0.0037 16.7 21.6 0.0047 16.3 2.1 5.0 3 2 3 6 6 6 2 WD40-like domain DUF1664 PF07889.12 ETO32119.1 - 0.11 12.5 4.1 0.21 11.6 4.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1664) Atg14 PF10186.9 ETO32119.1 - 0.27 10.3 9.0 0.42 9.6 9.0 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 ETO32119.1 - 2.9 8.4 18.3 1.8 9.1 6.9 2.4 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF2232 PF09991.9 ETO32119.1 - 3.2 6.8 4.6 4.6 6.3 4.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2232) DUF4199 PF13858.6 ETO32119.1 - 5.2 7.4 7.1 9.6 6.6 7.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) MutS_V PF00488.21 ETO32120.1 - 9.8e-29 100.7 0.0 1.2e-28 100.5 0.0 1.0 1 0 0 1 1 1 1 MutS domain V B56 PF01603.20 ETO32121.1 - 2e-130 435.5 9.7 2.6e-130 435.1 9.7 1.2 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) WD40 PF00400.32 ETO32122.1 - 0.036 14.9 0.4 0.091 13.7 0.2 1.8 2 0 0 2 2 2 0 WD domain, G-beta repeat Zn-C2H2_12 PF18112.1 ETO32123.1 - 0.011 16.2 0.5 0.026 15.0 0.5 1.6 1 0 0 1 1 1 0 Autophagy receptor zinc finger-C2H2 domain PP2C PF00481.21 ETO32124.1 - 4.3e-51 174.0 0.1 4.7e-51 173.9 0.1 1.0 1 0 0 1 1 1 1 Protein phosphatase 2C PP2C_2 PF13672.6 ETO32124.1 - 3.3e-05 23.6 0.1 8.1e-05 22.4 0.1 1.6 1 1 0 1 1 1 1 Protein phosphatase 2C DUF2624 PF11116.8 ETO32124.1 - 0.073 14.0 0.1 0.17 12.8 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2624) PUB PF09409.10 ETO32125.1 - 6.9e-18 64.4 0.3 6.9e-18 64.4 0.3 1.5 2 0 0 2 2 2 1 PUB domain FliD_C PF07195.12 ETO32125.1 - 0.024 14.1 0.1 0.032 13.6 0.1 1.2 1 0 0 1 1 1 0 Flagellar hook-associated protein 2 C-terminus Flavi_NS4B PF01349.17 ETO32125.1 - 0.079 12.3 0.0 0.1 12.0 0.0 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4B BRCT_2 PF16589.5 ETO32126.1 - 0.066 13.6 0.7 0.1 13.0 0.7 1.7 1 1 0 1 1 1 0 BRCT domain, a BRCA1 C-terminus domain Myb_DNA-binding PF00249.31 ETO32127.1 - 0.0044 17.2 0.4 0.01 16.0 0.4 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO32127.1 - 0.018 15.3 0.6 0.056 13.7 0.6 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain Het-C PF07217.11 ETO32127.1 - 0.02 13.5 0.2 0.02 13.5 0.2 1.6 2 0 0 2 2 2 0 Heterokaryon incompatibility protein Het-C CelTOS PF18659.1 ETO32127.1 - 0.038 14.4 3.3 0.098 13.1 3.3 1.7 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites Myb_DNA-bind_2 PF08914.11 ETO32127.1 - 0.12 12.6 1.6 0.16 12.2 0.1 2.0 2 0 0 2 2 2 0 Rap1 Myb domain Pkinase PF00069.25 ETO32128.1 - 8.2e-43 146.7 0.0 1.2e-42 146.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain EF-hand_1 PF00036.32 ETO32128.1 - 2.5e-21 73.6 7.3 3.7e-05 23.0 0.0 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO32128.1 - 2.6e-18 66.2 12.3 1.8e-08 34.7 0.5 4.3 4 1 0 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO32128.1 - 1.5e-16 58.9 8.5 0.00037 20.2 0.0 4.7 4 0 0 4 4 4 4 EF-hand domain EF-hand_5 PF13202.6 ETO32128.1 - 5.4e-16 57.3 8.4 5.6e-05 22.5 0.2 4.5 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO32128.1 - 7e-14 51.4 5.4 0.0008 19.2 0.0 4.7 3 1 1 4 4 4 4 EF-hand domain pair Pkinase_Tyr PF07714.17 ETO32128.1 - 1.2e-13 51.0 0.0 2e-13 50.2 0.0 1.4 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_4 PF12763.7 ETO32128.1 - 0.0001 22.2 2.1 0.57 10.2 0.0 3.1 2 1 1 3 3 3 2 Cytoskeletal-regulatory complex EF hand EF-hand_14 PF17959.1 ETO32128.1 - 0.26 11.6 3.1 3.2 8.2 0.6 3.1 2 1 1 3 3 3 0 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO32128.1 - 0.28 11.5 11.4 0.32 11.3 0.7 3.2 4 0 0 4 4 4 0 Secreted protein acidic and rich in cysteine Ca binding region CAP_GLY PF01302.25 ETO32129.1 - 6.1e-32 109.5 5.2 1.3e-17 63.5 1.5 2.4 2 0 0 2 2 2 2 CAP-Gly domain Pkinase PF00069.25 ETO32129.1 - 0.0021 17.5 0.2 0.0021 17.5 0.2 1.6 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32129.1 - 0.083 12.2 0.1 0.14 11.5 0.1 1.2 1 0 0 1 1 1 0 Protein tyrosine kinase CDC45 PF02724.14 ETO32130.1 - 0.31 9.3 13.8 0.37 9.0 13.8 1.0 1 0 0 1 1 1 0 CDC45-like protein Kelch_6 PF13964.6 ETO32131.1 - 0.021 15.1 0.1 0.26 11.7 0.0 2.5 2 0 0 2 2 2 0 Kelch motif EFG_IV PF03764.18 ETO32132.1 - 4.8e-11 42.5 0.0 7.2e-11 41.9 0.0 1.2 1 0 0 1 1 1 1 Elongation factor G, domain IV Ribosomal_S30 PF04758.14 ETO32132.1 - 0.044 14.0 0.6 0.084 13.1 0.6 1.4 1 0 0 1 1 1 0 Ribosomal protein S30 Kelch_1 PF01344.25 ETO32133.1 - 1.1e-08 34.5 1.5 9.5e-05 21.9 0.2 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO32133.1 - 6e-05 22.9 6.4 0.021 14.8 0.3 5.0 6 0 0 6 6 6 1 Kelch motif Kelch_2 PF07646.15 ETO32133.1 - 0.0029 17.5 4.1 0.52 10.4 0.3 4.7 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO32133.1 - 0.021 15.1 0.1 0.21 11.9 0.0 2.7 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO32133.1 - 0.061 13.4 0.7 0.56 10.3 0.1 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO32133.1 - 0.1 13.0 5.5 8.3 6.9 0.6 4.2 4 0 0 4 4 4 0 Kelch motif Copper-bind PF00127.20 ETO32133.1 - 0.12 12.8 0.8 0.53 10.8 0.1 2.1 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family NACHT PF05729.12 ETO32135.1 - 2.1e-05 24.5 0.0 3.8e-05 23.7 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO32135.1 - 0.00049 19.4 0.3 0.00097 18.4 0.1 1.6 1 1 1 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 ETO32135.1 - 0.0027 18.1 0.0 0.0079 16.6 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain Torsin PF06309.11 ETO32135.1 - 0.0071 16.5 0.0 0.013 15.6 0.0 1.4 1 0 0 1 1 1 1 Torsin AAA_22 PF13401.6 ETO32135.1 - 0.02 15.2 0.0 0.039 14.2 0.0 1.5 1 0 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO32135.1 - 0.021 15.2 0.2 0.27 11.6 0.0 2.4 2 1 1 3 3 3 0 RNA helicase DAP3 PF10236.9 ETO32135.1 - 0.024 13.8 0.0 0.039 13.1 0.0 1.3 1 0 0 1 1 1 0 Mitochondrial ribosomal death-associated protein 3 Sigma54_activat PF00158.26 ETO32135.1 - 0.059 13.1 0.0 0.083 12.6 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_30 PF13604.6 ETO32135.1 - 0.13 12.0 0.1 0.31 10.7 0.1 1.6 1 1 1 2 2 2 0 AAA domain DUF2095 PF09868.9 ETO32138.1 - 0.023 14.7 0.0 0.036 14.1 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2095) DUF4407 PF14362.6 ETO32138.1 - 1 8.7 6.7 1 8.6 6.7 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Neisseria_TspB PF05616.13 ETO32139.1 - 0.032 12.7 7.8 0.044 12.3 7.8 1.3 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein HA2 PF04408.23 ETO32140.1 - 1.7e-22 79.7 0.0 3.6e-22 78.7 0.0 1.6 1 0 0 1 1 1 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETO32140.1 - 5.1e-14 52.6 0.1 1.5e-13 51.0 0.1 1.8 1 0 0 1 1 1 1 Helicase conserved C-terminal domain OB_NTP_bind PF07717.16 ETO32140.1 - 2.5e-08 34.1 0.0 7.3e-08 32.7 0.0 1.8 1 0 0 1 1 1 1 Oligonucleotide/oligosaccharide-binding (OB)-fold AAA_22 PF13401.6 ETO32140.1 - 0.0011 19.3 0.0 0.0035 17.6 0.0 1.9 1 0 0 1 1 1 1 AAA domain ResIII PF04851.15 ETO32140.1 - 0.0026 17.8 0.5 1.2 9.1 0.0 2.4 1 1 1 2 2 2 2 Type III restriction enzyme, res subunit T2SSE PF00437.20 ETO32140.1 - 0.003 16.7 0.0 0.0059 15.7 0.0 1.4 1 0 0 1 1 1 1 Type II/IV secretion system protein cobW PF02492.19 ETO32140.1 - 0.0033 17.0 0.2 0.018 14.6 0.0 2.1 2 0 0 2 2 2 1 CobW/HypB/UreG, nucleotide-binding domain TniB PF05621.11 ETO32140.1 - 0.0051 16.2 0.1 0.0096 15.3 0.1 1.3 1 0 0 1 1 1 1 Bacterial TniB protein ATPase PF06745.13 ETO32140.1 - 0.013 14.9 0.0 0.024 14.0 0.0 1.4 1 0 0 1 1 1 0 KaiC DEAD PF00270.29 ETO32140.1 - 0.017 14.9 2.3 1.8 8.3 0.1 2.5 1 1 1 2 2 2 0 DEAD/DEAH box helicase TrwB_AAD_bind PF10412.9 ETO32140.1 - 0.02 13.8 0.2 0.69 8.8 0.0 2.6 3 0 0 3 3 3 0 Type IV secretion-system coupling protein DNA-binding domain AAA_23 PF13476.6 ETO32140.1 - 0.038 14.5 0.1 0.11 13.0 0.1 1.7 1 1 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO32140.1 - 0.052 12.9 0.0 0.13 11.6 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family PhoH PF02562.16 ETO32140.1 - 0.068 12.6 0.3 0.4 10.1 0.3 2.1 1 1 0 1 1 1 0 PhoH-like protein SRPRB PF09439.10 ETO32140.1 - 0.075 12.5 0.4 8.6 5.8 0.0 2.7 3 0 0 3 3 3 0 Signal recognition particle receptor beta subunit AAA_7 PF12775.7 ETO32140.1 - 0.083 12.4 0.0 0.16 11.5 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_29 PF13555.6 ETO32140.1 - 0.11 12.3 0.1 0.32 10.8 0.0 1.8 2 0 0 2 2 2 0 P-loop containing region of AAA domain SRP54 PF00448.22 ETO32140.1 - 0.12 12.0 0.0 0.23 11.1 0.0 1.5 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain WD40 PF00400.32 ETO32141.1 - 2.8e-35 119.7 30.0 5.4e-07 30.2 0.5 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32141.1 - 7.6e-11 42.2 0.3 0.038 14.3 0.0 4.8 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32141.1 - 1.1e-08 34.2 6.9 0.031 12.9 0.1 4.4 2 1 1 3 3 3 3 Nucleoporin Nup120/160 DUF851 PF05867.11 ETO32141.1 - 0.054 13.0 0.0 0.095 12.2 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF851) Cwf_Cwc_15 PF04889.12 ETO32142.1 - 0.37 10.5 3.2 0.42 10.3 3.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein eRF1_2 PF03464.15 ETO32143.1 - 2.5e-16 60.2 0.0 5.5e-16 59.1 0.0 1.6 1 0 0 1 1 1 1 eRF1 domain 2 eRF1_1 PF03463.15 ETO32143.1 - 1.1e-13 51.3 0.0 1.8e-13 50.6 0.0 1.3 1 0 0 1 1 1 1 eRF1 domain 1 Ribosomal_S15 PF00312.22 ETO32143.1 - 0.034 14.3 0.2 0.081 13.1 0.2 1.6 1 0 0 1 1 1 0 Ribosomal protein S15 TPR_1 PF00515.28 ETO32144.1 - 0.0024 17.6 0.7 0.0058 16.4 0.7 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32144.1 - 0.25 11.6 0.2 0.25 11.6 0.2 2.0 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ETO32145.1 - 1.1e-22 79.8 11.0 3.1e-08 34.1 1.1 4.4 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO32145.1 - 1.2e-06 27.6 1.6 0.024 13.3 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32145.1 - 8.4e-06 26.0 0.2 0.01 16.1 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO32145.1 - 0.067 11.9 2.1 0.13 10.9 2.1 1.4 1 1 0 1 1 1 0 Nup133 N terminal like Kelch_1 PF01344.25 ETO32146.1 - 1.3e-07 31.1 1.5 0.00019 21.0 0.4 3.0 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO32146.1 - 1.5e-06 27.9 6.6 0.011 15.7 0.2 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO32146.1 - 4.4e-05 23.6 3.0 1.2 9.5 0.4 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO32146.1 - 0.00084 19.3 1.8 3.7 7.6 0.4 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO32146.1 - 0.0011 19.0 0.0 0.13 12.3 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO32146.1 - 0.17 12.2 0.5 21 5.6 0.0 3.9 5 0 0 5 5 5 0 Galactose oxidase, central domain WD40 PF00400.32 ETO32148.1 - 1.9e-64 212.0 18.1 4.5e-10 40.0 0.5 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32148.1 - 6.4e-23 80.9 0.6 0.00016 21.9 0.0 6.7 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32148.1 - 2.3e-20 72.8 1.0 0.015 14.3 0.0 7.0 1 1 6 7 7 7 7 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO32148.1 - 6.7e-13 48.9 0.0 3.1e-05 23.9 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO32148.1 - 3e-11 43.2 1.5 0.00015 21.2 0.1 3.3 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO32148.1 - 2.5e-07 29.7 5.2 0.65 8.6 0.3 5.5 1 1 4 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO32148.1 - 6.7e-05 21.6 2.6 0.27 9.7 0.5 3.0 2 1 2 4 4 4 4 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO32148.1 - 0.00011 21.9 0.2 0.00067 19.3 0.2 2.1 2 1 0 2 2 2 1 PQQ-like domain DUF5570 PF17731.1 ETO32148.1 - 0.00025 21.1 2.6 5.2 7.2 0.0 4.7 1 1 4 5 5 5 1 Family of unknown function (DUF5570) Coatomer_WDAD PF04053.14 ETO32148.1 - 0.00032 19.9 0.5 0.47 9.4 0.0 2.5 1 1 1 2 2 2 2 Coatomer WD associated region PD40 PF07676.12 ETO32148.1 - 0.0049 16.8 15.9 2.1 8.4 0.1 6.2 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO32148.1 - 0.029 14.3 0.0 3.7 7.7 0.0 3.5 3 0 0 3 3 3 0 PQQ enzyme repeat SBD PF17882.1 ETO32148.1 - 0.17 11.7 1.2 84 3.0 0.1 3.8 3 1 2 5 5 5 0 OAA-family lectin sugar binding domain Condensin2nSMC PF12422.8 ETO32149.1 - 0.0082 16.3 2.0 0.0099 16.1 2.0 1.1 1 0 0 1 1 1 1 Condensin II non structural maintenance of chromosomes subunit RPA_interact_N PF14766.6 ETO32149.1 - 0.12 12.1 0.0 0.21 11.2 0.0 1.4 1 0 0 1 1 1 0 Replication protein A interacting N-terminal Myb_DNA-binding PF00249.31 ETO32151.1 - 1.3e-09 38.1 0.0 2.5e-09 37.2 0.0 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_7 PF15963.5 ETO32151.1 - 1.8e-05 24.6 1.5 3.7e-05 23.5 0.1 2.2 1 1 1 2 2 2 1 Myb DNA-binding like TMEM154 PF15102.6 ETO32151.1 - 3.4e-05 23.8 9.3 6.7e-05 22.8 5.5 2.9 3 0 0 3 3 3 1 TMEM154 protein family Orf78 PF06024.12 ETO32151.1 - 0.00029 21.1 1.5 0.00029 21.1 1.5 4.3 4 0 0 4 4 3 1 Orf78 (ac78) RIFIN PF02009.16 ETO32151.1 - 0.0033 17.4 2.1 0.0033 17.4 2.1 3.7 3 1 1 4 4 2 1 Rifin DAG1 PF05454.11 ETO32151.1 - 0.0093 15.4 0.3 0.019 14.3 0.3 1.5 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) Myb_DNA-bind_6 PF13921.6 ETO32151.1 - 0.012 15.9 0.0 0.028 14.7 0.0 1.6 1 0 0 1 1 1 0 Myb-like DNA-binding domain DUF5383 PF17355.2 ETO32151.1 - 0.013 15.9 0.1 0.013 15.9 0.1 3.3 4 1 1 5 5 3 0 Family of unknown function (DUF5383) Tmemb_9 PF05434.11 ETO32151.1 - 0.025 14.5 0.5 0.025 14.5 0.5 4.1 4 1 0 4 4 3 0 TMEM9 AA_permease_2 PF13520.6 ETO32151.1 - 0.028 13.2 10.7 0.37 9.6 3.3 2.3 3 0 0 3 3 3 0 Amino acid permease EVI2A PF05399.11 ETO32151.1 - 0.04 13.5 0.3 0.04 13.5 0.3 2.5 3 0 0 3 3 2 0 Ectropic viral integration site 2A protein (EVI2A) DUF2207 PF09972.9 ETO32151.1 - 0.064 12.0 12.0 0.1 11.3 0.9 2.8 3 0 0 3 3 3 0 Predicted membrane protein (DUF2207) DUF5305 PF17231.2 ETO32151.1 - 0.065 12.6 4.6 0.65 9.4 2.5 3.0 3 0 0 3 3 3 0 Family of unknown function (DUF5305) DUF4191 PF13829.6 ETO32151.1 - 0.089 12.1 1.2 0.14 11.5 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) SARAF PF06682.12 ETO32151.1 - 0.13 11.9 1.5 5.4 6.6 0.3 2.7 3 0 0 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis Shisa PF13908.6 ETO32151.1 - 0.4 10.9 11.1 0.14 12.4 2.8 3.0 3 0 0 3 3 3 0 Wnt and FGF inhibitory regulator MMPL PF03176.15 ETO32151.1 - 2.2 7.1 5.8 0.37 9.7 2.0 1.6 2 0 0 2 2 2 0 MMPL family Protocadherin PF08374.11 ETO32151.1 - 5.2 7.0 16.6 0.84 9.6 3.8 2.4 2 0 0 2 2 2 0 Protocadherin Baculo_11_kDa PF06143.11 ETO32151.1 - 5.3 6.7 19.6 4.3 7.0 7.5 3.5 3 0 0 3 3 3 0 Baculovirus 11 kDa family PRIMA1 PF16101.5 ETO32151.1 - 8.7 6.4 10.0 3 7.9 2.7 2.9 2 1 0 2 2 2 0 Proline-rich membrane anchor 1 RNA_binding PF01877.17 ETO32153.1 - 0.16 12.3 2.7 0.33 11.2 0.8 2.1 2 0 0 2 2 2 0 RNA binding HMG_box_5 PF14887.6 ETO32153.1 - 0.84 9.6 6.5 10 6.2 0.1 3.2 3 0 0 3 3 3 0 HMG (high mobility group) box 5 ING PF12998.7 ETO32153.1 - 1.2 9.8 6.4 0.77 10.4 3.6 2.2 2 1 0 2 2 2 0 Inhibitor of growth proteins N-terminal histone-binding TTL PF03133.15 ETO32154.1 - 5.9e-97 324.3 0.5 7.5e-97 324.0 0.5 1.1 1 0 0 1 1 1 1 Tubulin-tyrosine ligase family ATPgrasp_YheCD PF14398.6 ETO32154.1 - 1.2e-07 31.2 0.1 1.2e-05 24.7 0.0 2.5 2 1 1 3 3 3 2 YheC/D like ATP-grasp ATPgrasp_ST PF14397.6 ETO32154.1 - 0.00013 21.4 0.0 0.0032 16.8 0.0 2.2 2 0 0 2 2 2 1 Sugar-transfer associated ATP-grasp CUE PF02845.16 ETO32156.1 - 0.0028 17.3 0.2 0.0028 17.3 0.2 1.9 2 0 0 2 2 2 1 CUE domain PUB PF09409.10 ETO32156.1 - 0.14 12.1 1.7 0.72 9.8 1.7 2.2 1 1 0 1 1 1 0 PUB domain Rho_Binding PF08912.11 ETO32157.1 - 1.4 9.8 7.7 3.3 8.6 0.2 4.1 4 0 0 4 4 4 0 Rho Binding Med9 PF07544.13 ETO32157.1 - 7.1 6.8 9.2 0.53 10.4 0.2 3.2 3 0 0 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 adh_short PF00106.25 ETO32158.1 - 4.6e-22 78.4 0.3 5.5e-22 78.2 0.3 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO32158.1 - 1e-16 61.2 0.2 1.3e-16 60.9 0.2 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO32158.1 - 1.6e-05 24.9 0.6 3.9e-05 23.7 0.6 1.5 1 1 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO32158.1 - 0.027 13.6 0.1 0.031 13.4 0.1 1.2 1 0 0 1 1 1 0 Polysaccharide biosynthesis protein Methyltransf_25 PF13649.6 ETO32158.1 - 0.047 14.4 0.0 0.078 13.7 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain Sacchrp_dh_NADP PF03435.18 ETO32158.1 - 0.075 13.3 0.2 0.1 12.8 0.2 1.2 1 0 0 1 1 1 0 Saccharopine dehydrogenase NADP binding domain SAM_KSR1 PF13543.6 ETO32158.1 - 0.74 10.0 2.6 1.2 9.3 0.4 2.3 2 1 1 3 3 3 0 SAM like domain present in kinase suppressor RAS 1 His_Phos_1 PF00300.22 ETO32160.1 - 2.8e-34 118.5 0.0 9e-26 90.8 0.0 2.1 1 1 1 2 2 2 2 Histidine phosphatase superfamily (branch 1) Kelch_4 PF13418.6 ETO32161.1 - 0.00014 21.8 0.5 0.0028 17.6 0.2 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO32161.1 - 0.0017 18.3 0.9 3 7.9 0.8 4.2 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO32161.1 - 0.0034 17.0 0.8 6 6.5 0.0 3.7 4 0 0 4 4 4 2 Kelch motif CCDC32 PF14989.6 ETO32161.1 - 0.077 13.0 1.3 2.5 8.1 0.0 2.3 2 0 0 2 2 2 0 Coiled-coil domain containing 32 SNARE_assoc PF09335.11 ETO32163.1 - 5.3e-09 36.6 2.3 4.5e-08 33.6 1.4 2.3 2 1 0 2 2 2 1 SNARE associated Golgi protein Sigma_reg_N PF13800.6 ETO32163.1 - 0.018 15.3 0.2 0.043 14.1 0.2 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal Peptidase_M50B PF13398.6 ETO32163.1 - 0.058 13.0 4.9 0.083 12.5 4.9 1.3 1 0 0 1 1 1 0 Peptidase M50B-like Insulin_TMD PF17870.1 ETO32163.1 - 0.077 13.1 1.1 0.17 12.0 1.1 1.5 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF4834 PF16118.5 ETO32163.1 - 1.7 9.7 5.1 0.86 10.6 1.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO32164.1 - 2.6e-50 167.3 29.0 7.3e-08 33.0 0.0 11.7 11 0 0 11 11 11 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32164.1 - 1.6e-23 82.8 8.8 0.025 14.9 0.0 10.7 7 2 3 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32164.1 - 1.5e-08 33.8 13.5 0.0096 14.6 0.1 5.9 2 2 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32164.1 - 7.8e-06 25.4 8.1 3.9e-05 23.1 0.8 6.3 4 3 1 5 5 5 2 WD40-like domain Ge1_WD40 PF16529.5 ETO32164.1 - 2.2e-05 23.6 12.4 0.055 12.4 0.0 6.4 3 2 4 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO32164.1 - 2.2e-05 24.2 0.0 0.71 9.9 0.0 3.8 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat SBD PF17882.1 ETO32164.1 - 0.025 14.4 1.9 14 5.5 0.1 3.6 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain Proteasome_A_N PF10584.9 ETO32164.1 - 1.1 9.1 3.4 59 3.5 0.0 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO32164.1 - 1.7 8.7 11.7 6.2 6.9 0.0 4.9 4 1 2 6 6 6 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO32165.1 - 8.2e-36 121.4 29.0 2.1e-05 25.2 0.6 7.7 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32165.1 - 4.5e-08 33.3 1.5 1.6 9.1 0.0 5.6 4 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32165.1 - 5.9e-05 21.9 6.6 0.19 10.4 0.9 4.8 2 2 1 3 3 3 2 Nucleoporin Nup120/160 UCH PF00443.29 ETO32169.1 - 1.1e-24 87.3 1.6 1.1e-24 87.3 1.6 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase OmpH PF03938.14 ETO32169.1 - 0.0017 18.7 17.2 0.015 15.6 14.0 2.3 2 1 0 2 2 2 1 Outer membrane protein (OmpH-like) UCH_1 PF13423.6 ETO32169.1 - 0.0065 16.1 0.3 0.0065 16.1 0.3 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Spc24 PF08286.11 ETO32169.1 - 0.021 15.1 6.0 0.021 15.1 6.0 1.8 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 Guanylate_cyc PF00211.20 ETO32169.1 - 0.14 11.8 0.0 0.3 10.7 0.0 1.4 1 0 0 1 1 1 0 Adenylate and Guanylate cyclase catalytic domain LMBR1 PF04791.16 ETO32169.1 - 0.31 9.9 4.7 0.35 9.7 4.7 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Xpo1 PF08389.12 ETO32169.1 - 1.3 9.1 7.0 0.2 11.7 0.3 2.4 1 1 1 2 2 2 0 Exportin 1-like protein DUF4191 PF13829.6 ETO32169.1 - 4.5 6.5 6.0 1.4 8.2 3.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4191) EMC3_TMCO1 PF01956.16 ETO32169.1 - 8.1 6.1 8.0 12 5.6 8.0 1.4 1 1 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like EMP24_GP25L PF01105.24 ETO32169.1 - 8.5 6.3 9.0 29 4.5 5.4 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD zf-RING_2 PF13639.6 ETO32170.1 - 8.6e-06 26.0 2.6 8.6e-06 26.0 2.6 2.0 2 0 0 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ETO32170.1 - 0.00093 19.4 2.3 0.0026 18.0 2.3 1.8 1 0 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_3 PF13920.6 ETO32170.1 - 0.004 17.0 1.2 0.004 17.0 1.2 1.7 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO32170.1 - 0.0059 16.5 2.8 0.0059 16.5 2.8 2.0 2 0 0 2 2 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO32170.1 - 0.0085 16.0 3.5 0.0085 16.0 3.5 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ETO32170.1 - 0.0094 16.0 1.2 0.022 14.8 1.2 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-RING_11 PF17123.5 ETO32170.1 - 0.047 13.4 2.8 0.26 11.1 2.8 2.3 1 1 0 1 1 1 0 RING-like zinc finger Csm1_N PF18504.1 ETO32170.1 - 0.048 14.0 3.7 0.072 13.4 0.2 2.4 2 0 0 2 2 2 0 Csm1 N-terminal domain Cys_rich_KTR PF14205.6 ETO32170.1 - 0.099 12.5 1.4 0.25 11.2 1.4 1.6 1 0 0 1 1 1 0 Cysteine-rich KTR zf-C3H2C3 PF17122.5 ETO32170.1 - 0.16 12.0 5.1 2.4 8.3 5.1 2.4 1 1 0 1 1 1 0 Zinc-finger PfUIS3 PF11567.8 ETO32170.1 - 0.75 10.2 4.7 0.43 11.0 2.0 2.0 2 0 0 2 2 2 0 Plasmodium falciparum UIS3 membrane protein zf-C3HC4_2 PF13923.6 ETO32170.1 - 5.9 6.8 9.1 0.43 10.5 3.0 2.3 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO32171.1 - 8.6e-09 35.6 10.0 8.6e-09 35.6 10.0 1.8 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO32171.1 - 1.4e-06 28.0 5.1 1.4e-06 28.0 5.1 2.4 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO32171.1 - 4.6e-06 26.4 6.8 4.6e-06 26.4 6.8 2.0 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO32171.1 - 7e-06 25.7 7.4 7e-06 25.7 7.4 2.4 3 0 0 3 3 3 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO32171.1 - 5.1e-05 23.2 5.0 5.1e-05 23.2 5.0 2.6 2 0 0 2 2 2 1 RING-type zinc-finger PHD PF00628.29 ETO32171.1 - 0.0001 22.1 5.9 0.0001 22.1 5.9 2.2 2 0 0 2 2 2 1 PHD-finger zf-rbx1 PF12678.7 ETO32171.1 - 0.0015 18.8 10.2 0.0015 18.8 10.2 2.4 2 1 0 2 2 2 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETO32171.1 - 0.0053 16.7 8.7 0.012 15.6 7.2 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETO32171.1 - 0.014 15.6 5.8 0.014 15.6 5.8 2.3 1 1 1 2 2 1 0 zinc finger of C3HC4-type, RING Zn-ribbon_8 PF09723.10 ETO32171.1 - 0.05 13.7 0.7 0.05 13.7 0.7 2.4 3 0 0 3 3 3 0 Zinc ribbon domain zf-ANAPC11 PF12861.7 ETO32171.1 - 0.12 12.4 10.3 0.055 13.5 7.0 2.1 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 11 RING-H2 finger PHD_4 PF16866.5 ETO32171.1 - 0.48 10.6 9.4 1.7 8.8 7.7 2.7 2 1 0 2 2 2 0 PHD-finger zf-MIZ PF02891.20 ETO32171.1 - 0.63 9.8 7.3 2.2 8.1 7.4 1.9 1 1 1 2 2 2 0 MIZ/SP-RING zinc finger zf-HC5HC2H PF13771.6 ETO32171.1 - 1.3 9.3 11.3 0.3 11.4 5.6 2.3 1 1 1 2 2 2 0 PHD-like zinc-binding domain Zn_ribbon_17 PF17120.5 ETO32171.1 - 3.6 7.3 14.4 9.5 5.9 14.4 1.8 1 1 0 1 1 1 0 Zinc-ribbon, C4HC2 type CLN3 PF02487.17 ETO32174.1 - 1.6e-25 90.0 11.1 1.9e-25 89.8 11.1 1.0 1 0 0 1 1 1 1 CLN3 protein WD40 PF00400.32 ETO32176.1 - 6.7e-19 67.9 20.6 7.6e-06 26.6 0.5 6.8 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32176.1 - 9e-06 25.9 1.7 1.2 9.5 0.0 4.7 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain BRCT PF00533.26 ETO32176.1 - 0.025 15.0 1.6 0.58 10.6 0.1 2.7 2 0 0 2 2 2 0 BRCA1 C Terminus (BRCT) domain WD40 PF00400.32 ETO32177.1 - 1.2e-67 222.1 20.3 2.2e-10 41.0 0.6 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32177.1 - 6.8e-17 61.5 2.1 0.0073 16.6 0.0 6.2 1 1 6 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32177.1 - 6.3e-13 48.4 0.1 0.52 9.2 0.0 6.0 2 2 4 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO32177.1 - 1.7e-12 47.7 0.2 7.2e-06 26.0 0.0 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO32177.1 - 1.8e-07 30.8 0.0 0.019 14.3 0.0 4.1 3 1 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO32177.1 - 5.4e-05 22.0 7.7 1.2 7.7 0.0 4.9 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO32177.1 - 0.00016 20.3 0.3 0.28 9.7 0.0 3.0 1 1 3 4 4 4 3 Cytochrome D1 heme domain Str_synth PF03088.16 ETO32177.1 - 0.00049 20.2 0.0 10 6.3 0.0 4.4 4 3 0 4 4 4 2 Strictosidine synthase PD40 PF07676.12 ETO32177.1 - 0.013 15.4 10.5 9.1 6.4 0.0 5.3 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO32177.1 - 0.56 9.9 13.1 3.1 7.6 0.0 5.0 4 1 1 5 5 5 0 Proteasome subunit A N-terminal signature Ribosomal_L27_C PF18471.1 ETO32178.1 - 0.00012 21.6 2.1 0.00016 21.2 1.4 1.6 1 1 1 2 2 2 1 Ribosomal L27 protein C-terminal domain SAM_1 PF00536.30 ETO32179.1 - 2.1e-06 28.0 0.2 7.7e-06 26.3 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO32179.1 - 0.00048 20.2 0.2 0.0018 18.3 0.1 1.9 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SDA1 PF05285.12 ETO32179.1 - 0.21 11.0 14.8 0.24 10.8 14.8 1.1 1 0 0 1 1 1 0 SDA1 MDFI PF15316.6 ETO32179.1 - 0.96 9.5 2.5 2.1 8.4 2.5 1.6 1 0 0 1 1 1 0 MyoD family inhibitor Ank_2 PF12796.7 ETO32180.1 - 0.0023 18.5 1.7 0.011 16.3 0.2 2.7 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) CENP-B_dimeris PF09026.10 ETO32180.1 - 0.04 14.3 7.2 0.12 12.8 0.2 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Peptidase_M16 PF00675.20 ETO32181.1 - 4e-27 95.0 0.3 5.6e-27 94.6 0.3 1.2 1 0 0 1 1 1 1 Insulinase (Peptidase family M16) Peptidase_M16_M PF16187.5 ETO32182.1 - 2.2e-46 158.4 2.0 2.2e-46 158.4 2.0 1.6 2 0 0 2 2 2 1 Middle or third domain of peptidase_M16 Peptidase_M16_C PF05193.21 ETO32182.1 - 6.6e-20 71.9 0.3 9.4e-09 35.5 0.1 3.2 3 0 0 3 3 3 2 Peptidase M16 inactive domain Hormone_1 PF00103.20 ETO32182.1 - 0.018 14.8 0.0 0.046 13.5 0.0 1.6 1 0 0 1 1 1 0 Somatotropin hormone family SNARE PF05739.19 ETO32182.1 - 0.26 11.3 3.3 0.16 12.0 1.1 1.8 2 0 0 2 2 2 0 SNARE domain WD40 PF00400.32 ETO32183.1 - 1e-38 130.6 31.7 6.5e-06 26.8 0.6 8.6 8 2 0 8 8 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO32183.1 - 2.6e-11 42.9 0.5 0.31 9.6 0.0 5.7 3 2 3 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32183.1 - 1e-09 38.6 2.5 0.046 14.0 0.0 6.7 5 2 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO32183.1 - 4.8e-06 27.2 5.5 4.8e-06 27.2 5.5 2.9 3 0 0 3 3 3 1 TRAF-type zinc finger MIR PF02815.19 ETO32183.1 - 0.00059 19.7 1.5 0.78 9.6 0.0 3.5 2 1 0 3 3 3 1 MIR domain WD40_like PF17005.5 ETO32183.1 - 0.076 12.3 10.5 1.8 7.8 0.1 4.9 4 2 1 6 6 6 0 WD40-like domain PQQ_3 PF13570.6 ETO32183.1 - 0.2 12.2 2.0 10 6.7 0.1 4.1 4 1 1 5 5 5 0 PQQ-like domain DUF5082 PF16888.5 ETO32183.1 - 0.34 11.2 15.5 0.42 10.9 11.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF5082) FapA PF03961.13 ETO32183.1 - 1.2 7.6 9.5 1.9 7.0 9.5 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A TSC22 PF01166.18 ETO32183.1 - 1.6 9.1 14.4 0.21 11.9 2.0 3.3 4 0 0 4 4 4 0 TSC-22/dip/bun family PTPlike_phytase PF14566.6 ETO32183.1 - 2 8.5 5.2 5.4 7.1 5.2 1.7 1 0 0 1 1 1 0 Inositol hexakisphosphate Jnk-SapK_ap_N PF09744.9 ETO32183.1 - 3.1 8.0 18.3 0.25 11.6 12.8 1.8 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 CENP-F_leu_zip PF10473.9 ETO32183.1 - 7.3 6.6 22.0 1.3 9.1 15.6 2.6 2 0 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 AAA_33 PF13671.6 ETO32184.1 - 7.1e-07 29.5 0.1 2.3e-06 27.9 0.1 1.8 1 0 0 1 1 1 1 AAA domain DUF334 PF03904.13 ETO32184.1 - 1.5 8.3 6.9 3 7.3 6.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF334) SH3_3 PF08239.11 ETO32185.1 - 0.058 13.7 0.0 0.12 12.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial SH3 domain SR-25 PF10500.9 ETO32187.1 - 0.00057 19.6 4.8 0.00064 19.4 4.8 1.2 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Phage_pRha PF09669.10 ETO32187.1 - 0.035 14.6 0.1 0.14 12.7 0.0 1.8 1 1 1 2 2 2 0 Phage regulatory protein Rha (Phage_pRha) IMUP PF15761.5 ETO32187.1 - 0.039 14.7 4.2 0.068 13.9 4.2 1.4 1 0 0 1 1 1 0 Immortalisation up-regulated protein PPP5 PF08321.12 ETO32187.1 - 0.49 10.7 3.9 0.61 10.4 0.7 2.3 1 1 1 2 2 2 0 PPP5 TPR repeat region WD40 PF00400.32 ETO32188.1 - 2.9e-27 94.3 34.3 4.8e-07 30.4 0.2 7.3 7 1 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32188.1 - 9.1e-09 35.5 0.7 0.0037 17.5 0.0 4.7 4 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32188.1 - 7.6e-05 21.5 6.8 3.3 6.2 0.0 5.4 1 1 2 5 5 5 4 Nucleoporin Nup120/160 EFG_IV PF03764.18 ETO32189.1 - 1.4e-22 79.8 0.0 2.7e-22 78.8 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_C PF00679.24 ETO32189.1 - 5.9e-16 58.3 0.0 1e-15 57.5 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_II PF14492.6 ETO32189.1 - 2e-09 37.4 0.0 3.8e-09 36.5 0.0 1.3 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ETO32189.1 - 0.00034 20.9 0.0 0.0017 18.7 0.0 2.2 1 1 0 1 1 1 1 Elongation factor Tu domain 2 WD40 PF00400.32 ETO32190.1 - 2.1e-49 164.4 18.3 1.7e-08 34.9 0.1 8.8 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32190.1 - 1.5e-15 57.2 4.5 0.011 16.0 0.0 8.2 3 1 6 9 9 8 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32190.1 - 1.4e-10 41.0 9.5 0.0036 16.7 0.0 5.2 5 1 1 6 6 6 3 WD40-like domain eIF2A PF08662.11 ETO32190.1 - 3.2e-10 40.2 0.8 0.00022 21.2 0.0 3.9 2 1 2 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO32190.1 - 3.2e-08 32.9 2.8 0.16 10.9 0.1 5.4 3 2 2 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_5 PF13854.6 ETO32190.1 - 4e-07 29.9 1.4 0.55 10.3 0.0 4.9 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO32190.1 - 3e-06 27.3 5.4 0.15 12.4 0.2 5.4 4 1 1 5 5 4 2 Kelch motif Kelch_3 PF13415.6 ETO32190.1 - 9e-06 25.8 0.1 0.019 15.2 0.0 3.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Nbas_N PF15492.6 ETO32190.1 - 0.0001 21.8 2.1 0.67 9.2 0.0 4.2 5 0 0 5 5 5 2 Neuroblastoma-amplified sequence, N terminal Kelch_2 PF07646.15 ETO32190.1 - 0.00025 20.9 3.9 0.44 10.6 0.4 4.3 5 0 0 5 5 4 2 Kelch motif PD40 PF07676.12 ETO32190.1 - 0.00036 20.4 2.4 7.1 6.7 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Kelch_4 PF13418.6 ETO32190.1 - 0.001 19.0 3.1 1 9.4 0.1 3.8 4 0 0 4 4 3 2 Galactose oxidase, central domain Cytochrom_D1 PF02239.16 ETO32190.1 - 0.0011 17.6 0.6 2 6.9 0.0 3.2 2 1 1 3 3 3 2 Cytochrome D1 heme domain Kelch_1 PF01344.25 ETO32190.1 - 0.0026 17.3 5.3 1.5 8.5 0.2 3.7 4 0 0 4 4 4 2 Kelch motif BBS2_Mid PF14783.6 ETO32190.1 - 0.051 13.6 0.3 5.8 7.0 0.1 3.6 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region Ank_4 PF13637.6 ETO32191.1 - 0.064 13.9 0.2 2.3 8.9 0.3 2.3 1 1 1 2 2 2 0 Ankyrin repeats (many copies) DUF3464 PF11947.8 ETO32191.1 - 0.13 12.0 0.0 0.35 10.6 0.0 1.7 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 RVT_1 PF00078.27 ETO32192.1 - 0.0092 15.5 0.3 0.24 10.9 0.3 2.2 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) BPL_C PF02237.17 ETO32193.1 - 0.025 14.5 0.0 0.034 14.1 0.0 1.2 1 0 0 1 1 1 0 Biotin protein ligase C terminal domain Hyr1 PF15789.5 ETO32193.1 - 0.077 12.6 0.2 0.13 11.8 0.2 1.6 1 1 0 1 1 1 0 Hyphally regulated cell wall GPI-anchored protein 1 Mak16 PF04874.14 ETO32195.1 - 0.049 14.2 0.1 0.083 13.5 0.1 1.3 1 0 0 1 1 1 0 Mak16 protein C-terminal region DUF1515 PF07439.11 ETO32196.1 - 0.19 11.7 0.2 0.7 9.9 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) YadA_anchor PF03895.15 ETO32196.1 - 1 9.5 3.5 2.1 8.5 3.5 1.5 1 0 0 1 1 1 0 YadA-like membrane anchor domain YcgL PF05166.13 ETO32198.1 - 0.8 10.1 5.1 4.9 7.6 3.7 2.7 2 1 0 2 2 2 0 YcgL domain ADK PF00406.22 ETO32199.1 - 2.2e-07 31.1 0.7 4.9e-07 30.0 0.4 1.7 2 0 0 2 2 2 1 Adenylate kinase MMR_HSR1 PF01926.23 ETO32199.1 - 0.0041 17.2 0.0 0.011 15.8 0.0 1.7 1 0 0 1 1 1 1 50S ribosome-binding GTPase AAA_18 PF13238.6 ETO32199.1 - 0.011 16.2 0.1 0.028 15.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ETO32199.1 - 0.049 14.1 0.5 0.14 12.5 0.1 2.0 2 0 0 2 2 2 0 AAA domain FeoB_N PF02421.18 ETO32199.1 - 0.07 12.7 0.0 0.22 11.0 0.0 1.9 2 0 0 2 2 2 0 Ferrous iron transport protein B ATP_bind_1 PF03029.17 ETO32199.1 - 0.083 12.7 0.3 11 5.8 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein UBX PF00789.20 ETO32200.1 - 2.1e-10 40.7 0.0 4.1e-10 39.7 0.0 1.5 1 0 0 1 1 1 1 UBX domain CLASP_N PF12348.8 ETO32200.1 - 0.05 13.2 0.1 0.086 12.4 0.1 1.3 1 0 0 1 1 1 0 CLASP N terminal Acetyltransf_3 PF13302.7 ETO32201.1 - 3.8e-20 73.0 0.0 5.7e-20 72.4 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain KOW PF00467.29 ETO32202.1 - 0.082 12.9 1.7 0.082 12.9 1.7 2.2 2 1 0 2 2 2 0 KOW motif SNARE PF05739.19 ETO32205.1 - 0.00047 20.1 0.0 0.0013 18.6 0.0 1.8 1 0 0 1 1 1 1 SNARE domain DUF1397 PF07165.11 ETO32205.1 - 1.5 8.2 9.1 0.38 10.2 3.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF1397) CENP-H PF05837.12 ETO32205.1 - 4.2 7.8 6.6 0.45 10.9 1.5 2.0 2 0 0 2 2 2 0 Centromere protein H (CENP-H) Peptidase_C97 PF05903.14 ETO32206.1 - 2.7e-05 24.0 0.1 3.4e-05 23.7 0.1 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain QH-AmDH_gamma PF08992.11 ETO32206.1 - 0.026 14.5 0.0 0.072 13.1 0.0 1.8 1 1 0 1 1 1 0 Quinohemoprotein amine dehydrogenase, gamma subunit Glyco_hydro_47 PF01532.20 ETO32208.1 - 8.1e-46 156.9 0.3 1e-45 156.5 0.3 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Glyco_hydro_47 PF01532.20 ETO32209.1 - 1.3e-18 67.1 0.1 1.4e-18 67.1 0.1 1.0 1 0 0 1 1 1 1 Glycosyl hydrolase family 47 Ras PF00071.22 ETO32210.1 - 1.8e-45 154.5 0.1 2.4e-45 154.0 0.1 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO32210.1 - 4.6e-21 75.3 0.0 7.3e-21 74.6 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO32210.1 - 2e-07 30.6 0.0 3e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO32210.1 - 0.0005 19.7 0.0 0.00077 19.0 0.0 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain dUTPase_2 PF08761.11 ETO32211.1 - 0.023 14.8 0.4 0.029 14.5 0.4 1.2 1 0 0 1 1 1 0 dUTPase DUF678 PF05077.12 ETO32213.1 - 0.16 12.1 0.6 0.36 11.0 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF678) BLOC1_2 PF10046.9 ETO32214.1 - 0.0066 16.7 14.8 0.043 14.1 5.3 2.9 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF724 PF05266.14 ETO32214.1 - 0.015 15.1 7.1 0.015 15.1 7.1 2.6 3 1 1 4 4 4 0 Protein of unknown function (DUF724) DUF3450 PF11932.8 ETO32214.1 - 0.019 14.3 4.0 0.044 13.1 4.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF641 PF04859.12 ETO32214.1 - 0.024 15.0 5.1 0.024 15.0 5.1 2.5 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) Cep57_MT_bd PF06657.13 ETO32214.1 - 0.058 13.8 4.3 0.42 11.1 4.3 2.5 1 1 1 2 2 2 0 Centrosome microtubule-binding domain of Cep57 TFIIA PF03153.13 ETO32214.1 - 0.077 13.0 20.8 0.1 12.6 20.8 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit ACCA PF03255.14 ETO32214.1 - 0.17 11.8 7.2 0.49 10.3 5.0 2.4 2 0 0 2 2 2 0 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit DUF1664 PF07889.12 ETO32214.1 - 0.18 11.9 14.1 0.091 12.8 2.2 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF2203 PF09969.9 ETO32214.1 - 0.26 12.0 5.8 0.38 11.5 4.1 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) SlyX PF04102.12 ETO32214.1 - 0.28 11.8 6.6 1.4 9.6 6.5 2.3 1 1 0 1 1 1 0 SlyX DivIC PF04977.15 ETO32214.1 - 0.29 10.9 12.0 3.7 7.4 1.8 3.0 1 1 1 2 2 2 0 Septum formation initiator Csm2_III-A PF03750.13 ETO32214.1 - 0.46 11.3 6.8 0.19 12.6 3.6 2.1 2 0 0 2 2 2 0 Csm2 Type III-A NPV_P10 PF05531.12 ETO32214.1 - 0.66 10.5 10.6 8 7.0 10.6 2.4 1 1 0 1 1 1 0 Nucleopolyhedrovirus P10 protein DUF948 PF06103.11 ETO32214.1 - 0.93 9.8 4.0 2.2 8.6 4.0 1.7 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) Peptidase_C3 PF00548.20 ETO32214.1 - 0.94 9.4 6.8 0.1 12.6 1.4 2.1 2 0 0 2 2 2 0 3C cysteine protease (picornain 3C) DUF4407 PF14362.6 ETO32214.1 - 0.99 8.7 10.4 1.7 7.9 10.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) TMPIT PF07851.13 ETO32214.1 - 9 5.4 14.8 0.13 11.4 6.0 2.2 2 0 0 2 2 2 0 TMPIT-like protein RasGAP_C PF03836.15 ETO32215.1 - 2e-06 28.0 6.6 2e-06 28.0 6.6 2.2 1 1 1 2 2 2 1 RasGAP C-terminus SpoIIIAH PF12685.7 ETO32215.1 - 0.025 14.4 2.4 0.025 14.4 2.4 1.7 2 0 0 2 2 2 0 SpoIIIAH-like protein WD40 PF00400.32 ETO32216.1 - 1e-27 95.8 15.2 5.2e-06 27.1 0.1 7.3 7 2 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO32216.1 - 3e-12 46.0 4.8 0.00012 20.9 0.2 3.2 2 1 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32216.1 - 5.2e-08 33.1 0.8 4.3 7.7 0.0 5.4 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain YqzE PF14038.6 ETO32217.1 - 0.0052 16.8 0.8 0.011 15.8 0.8 1.4 1 0 0 1 1 1 1 YqzE-like protein DUF3931 PF13082.6 ETO32219.1 - 3 8.1 4.6 9.5 6.5 0.0 2.5 3 0 0 3 3 3 0 Protein of unknown function (DUF3931) PrmA PF06325.13 ETO32220.1 - 1.3e-05 24.8 0.9 0.0072 15.8 0.2 2.2 2 0 0 2 2 2 2 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_18 PF12847.7 ETO32220.1 - 9e-05 22.4 0.5 0.0037 17.2 0.2 2.2 2 0 0 2 2 2 1 Methyltransferase domain PRMT5 PF05185.16 ETO32220.1 - 0.00055 19.8 2.5 0.0012 18.7 2.5 1.6 1 1 0 1 1 1 1 PRMT5 arginine-N-methyltransferase TrmK PF04816.12 ETO32220.1 - 0.0017 17.9 0.8 0.0055 16.3 0.2 2.0 1 1 1 2 2 2 1 tRNA (adenine(22)-N(1))-methyltransferase Met_10 PF02475.16 ETO32220.1 - 0.022 14.5 0.2 0.33 10.7 0.1 2.4 2 0 0 2 2 2 0 Met-10+ like-protein DUF4731 PF15875.5 ETO32220.1 - 0.14 12.3 0.1 0.56 10.4 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4731) Methyltransf_31 PF13847.6 ETO32220.1 - 0.17 11.7 0.4 0.69 9.7 0.4 1.8 1 1 0 1 1 1 0 Methyltransferase domain TPR_12 PF13424.6 ETO32221.1 - 2.2e-36 124.0 5.8 2.7e-12 46.8 0.2 3.7 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32221.1 - 1.1e-21 75.9 0.6 1.5e-06 27.9 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32221.1 - 1.6e-18 65.3 1.4 0.00025 20.9 0.0 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32221.1 - 2.8e-15 55.4 18.7 0.00048 19.8 1.1 5.7 4 2 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32221.1 - 5.5e-13 48.0 10.7 0.0024 18.0 0.1 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32221.1 - 1.2e-12 46.9 13.9 0.0032 17.5 0.1 5.2 6 1 0 6 6 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32221.1 - 1.5e-08 34.1 16.9 0.16 11.7 0.1 6.2 3 2 2 5 5 5 4 TPR repeat TPR_6 PF13174.6 ETO32221.1 - 2.4e-05 24.7 2.5 1 10.2 0.1 4.3 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO32221.1 - 0.00046 20.8 0.0 41 5.4 0.0 4.6 4 1 0 5 5 4 0 Tetratricopeptide repeat SNAP PF14938.6 ETO32221.1 - 0.00053 19.5 0.5 0.0022 17.5 0.0 2.1 2 1 0 2 2 2 1 Soluble NSF attachment protein, SNAP TPR_17 PF13431.6 ETO32221.1 - 0.0051 17.1 8.8 4.6 7.9 0.5 4.3 2 1 1 3 3 3 2 Tetratricopeptide repeat Bactofilin PF04519.13 ETO32221.1 - 0.1 12.9 1.2 0.13 12.6 0.3 1.6 2 0 0 2 2 2 0 Polymer-forming cytoskeletal TPR_16 PF13432.6 ETO32221.1 - 0.19 12.4 0.0 13 6.5 0.0 3.2 3 1 0 3 3 2 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO32222.1 - 1.1e-08 35.3 0.3 3.6e-08 33.7 0.3 1.8 1 1 0 1 1 1 1 Caspase domain SH2_2 PF14633.6 ETO32222.1 - 0.002 17.6 1.0 0.2 11.0 0.2 2.3 1 1 1 2 2 2 2 SH2 domain tRNA-synt_2 PF00152.20 ETO32224.1 - 5e-60 203.2 0.1 5.9e-60 203.0 0.1 1.0 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2d PF01409.20 ETO32224.1 - 9.9e-09 35.0 0.1 0.00053 19.5 0.0 2.2 2 0 0 2 2 2 2 tRNA synthetases class II core domain (F) LRR_4 PF12799.7 ETO32226.1 - 5.4e-05 23.5 2.4 0.27 11.7 0.1 3.8 4 0 0 4 4 4 2 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO32226.1 - 0.0013 18.7 3.6 0.41 10.8 0.1 3.5 4 0 0 4 4 4 2 Leucine Rich repeat FANCF PF11107.8 ETO32226.1 - 0.013 14.7 0.6 3.3 6.8 0.1 2.1 2 0 0 2 2 2 0 Fanconi anemia group F protein (FANCF) LRR_1 PF00560.33 ETO32226.1 - 0.016 15.6 0.8 77 4.5 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_6 PF13516.6 ETO32227.1 - 8.4e-11 41.0 17.1 0.017 15.1 0.2 5.5 5 0 0 5 5 5 5 Leucine Rich repeat DUF1664 PF07889.12 ETO32228.1 - 0.025 14.6 5.3 0.59 10.2 1.0 2.5 2 1 0 2 2 2 0 Protein of unknown function (DUF1664) COG2 PF06148.11 ETO32228.1 - 0.33 11.0 5.3 0.21 11.6 1.1 2.1 2 0 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 SKA2 PF16740.5 ETO32228.1 - 0.52 10.1 11.6 0.65 9.8 0.2 2.9 2 1 1 3 3 3 0 Spindle and kinetochore-associated protein 2 Med21 PF11221.8 ETO32228.1 - 1.2 9.3 7.5 0.49 10.6 1.3 2.3 2 0 0 2 2 2 0 Subunit 21 of Mediator complex G10 PF01125.17 ETO32228.1 - 1.9 8.2 11.2 0.56 10.0 0.8 2.5 2 1 0 2 2 2 0 G10 protein DivIC PF04977.15 ETO32228.1 - 2 8.3 10.1 0.15 11.9 0.4 2.7 3 0 0 3 3 3 0 Septum formation initiator MtrG PF04210.13 ETO32228.1 - 2.5 8.0 4.3 10 6.0 0.3 2.7 2 0 0 2 2 2 0 Tetrahydromethanopterin S-methyltransferase, subunit G DUF1943 PF09172.11 ETO32228.1 - 2.8 7.1 10.2 0.073 12.3 2.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1943) Seryl_tRNA_N PF02403.22 ETO32228.1 - 2.8 8.2 14.6 1.3 9.2 1.5 2.4 2 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FUN14 PF04930.15 ETO32228.1 - 3.6 8.1 5.6 1.5 9.3 0.4 2.2 1 1 1 2 2 2 0 FUN14 family Citrate_bind PF16114.5 ETO32229.1 - 1.8e-85 284.9 0.0 3.1e-85 284.2 0.0 1.4 1 0 0 1 1 1 1 ATP citrate lyase citrate-binding ATP-grasp_2 PF08442.10 ETO32229.1 - 9.9e-07 28.5 0.1 0.0098 15.5 0.0 2.3 1 1 1 2 2 2 2 ATP-grasp domain Ligase_CoA PF00549.19 ETO32230.1 - 6.4e-07 29.3 0.0 1.2e-06 28.4 0.0 1.4 1 0 0 1 1 1 1 CoA-ligase CoA_binding PF02629.19 ETO32230.1 - 7.4e-06 26.6 0.7 1.7e-05 25.4 0.0 2.0 3 0 0 3 3 3 1 CoA binding domain Succ_CoA_lig PF13607.6 ETO32230.1 - 0.035 13.9 0.0 0.18 11.6 0.0 1.9 2 0 0 2 2 2 0 Succinyl-CoA ligase like flavodoxin domain Citrate_synt PF00285.21 ETO32231.1 - 1e-18 67.6 0.0 6.3e-16 58.4 0.0 2.8 1 1 1 2 2 2 2 Citrate synthase, C-terminal domain PCI PF01399.27 ETO32232.1 - 0.0023 18.4 2.6 0.0049 17.4 0.4 2.4 2 1 0 2 2 2 1 PCI domain Nif11 PF07862.11 ETO32232.1 - 0.1 12.9 0.4 0.22 11.9 0.4 1.5 1 0 0 1 1 1 0 Nif11 domain Fe-S_assembly PF04384.13 ETO32233.1 - 0.06 14.0 0.7 0.06 14.0 0.7 1.9 2 0 0 2 2 2 0 Iron-sulphur cluster assembly DUF4751 PF15942.5 ETO32233.1 - 0.11 12.5 0.4 14 5.6 0.0 2.2 1 1 0 2 2 2 0 Domain of unknown function (DUF4751) BAF PF02961.14 ETO32234.1 - 0.031 14.7 0.2 0.086 13.3 0.1 1.8 1 1 0 1 1 1 0 Barrier to autointegration factor DUF1160 PF06648.11 ETO32234.1 - 0.12 12.4 8.6 2 8.4 0.1 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1160) Cnd1 PF12717.7 ETO32234.1 - 0.65 10.0 8.2 0.19 11.8 2.3 2.0 1 1 1 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Caenor_Her-1 PF09232.10 ETO32235.1 - 1.8 8.7 8.1 0.42 10.7 3.5 2.2 2 1 1 3 3 3 0 Caenorhabditis elegans Her-1 Kelch_1 PF01344.25 ETO32236.1 - 6e-09 35.3 0.8 0.034 13.7 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO32236.1 - 5e-06 26.6 0.4 0.7 10.3 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO32236.1 - 0.00029 20.7 1.1 2.3 8.4 0.1 4.7 4 1 1 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO32236.1 - 0.00045 20.1 2.7 4.4 7.4 0.1 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 ETO32236.1 - 0.0016 18.4 0.0 1.6 8.8 0.0 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO32236.1 - 0.082 13.2 0.1 32 4.9 0.0 3.6 4 0 0 4 4 4 0 Galactose oxidase, central domain GF_recep_IV PF14843.6 ETO32236.1 - 1.8 8.4 7.8 0.15 11.9 1.8 2.1 2 0 0 2 2 2 0 Growth factor receptor domain IV Miff PF05644.11 ETO32239.1 - 2.1 7.9 13.2 0.23 11.1 2.0 2.9 3 1 0 3 3 3 0 Mitochondrial and peroxisomal fission factor Mff Sec23_trunk PF04811.15 ETO32240.1 - 4.5e-09 36.2 0.0 5.4e-09 36.0 0.0 1.0 1 0 0 1 1 1 1 Sec23/Sec24 trunk domain WD40 PF00400.32 ETO32243.1 - 2.2e-09 37.8 0.0 5.6e-06 27.0 0.0 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO32243.1 - 1.4e-06 27.8 4.9 0.0026 17.4 0.3 2.2 1 1 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO32243.1 - 0.0014 18.7 0.1 0.0024 18.0 0.1 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Ge1_WD40 PF16529.5 ETO32243.1 - 0.0049 15.9 0.0 0.0053 15.8 0.0 1.2 1 0 0 1 1 1 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO32243.1 - 0.027 14.8 0.0 0.035 14.4 0.0 1.2 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide_3 PF13576.6 ETO32243.1 - 0.031 14.4 3.2 0.042 14.0 0.5 2.3 2 1 1 3 3 3 0 Pentapeptide repeats (9 copies) Kinesin PF00225.23 ETO32244.1 - 1.5e-64 218.1 3.8 4e-40 137.8 0.1 2.2 1 1 1 2 2 2 2 Kinesin motor domain Microtub_bd PF16796.5 ETO32244.1 - 2.2e-18 66.7 0.8 3.2e-18 66.1 0.1 1.6 2 0 0 2 2 2 1 Microtubule binding zf-TRAF PF02176.18 ETO32245.1 - 5.2e-13 49.5 24.7 8.6e-10 39.2 6.7 3.4 2 1 1 3 3 3 3 TRAF-type zinc finger EbsA PF17255.2 ETO32245.1 - 0.012 16.0 1.8 0.021 15.2 1.8 1.3 1 0 0 1 1 1 0 EbsA-like protein zf-TRAF_2 PF15965.5 ETO32245.1 - 0.027 14.9 19.9 1.1 9.8 6.1 3.4 2 2 0 2 2 2 0 TRAF-like zinc-finger DUF3996 PF13161.6 ETO32245.1 - 0.038 13.7 0.7 0.061 13.0 0.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3996) LAP1C PF05609.12 ETO32246.1 - 0.28 10.2 21.6 0.34 10.0 21.6 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Caldesmon PF02029.15 ETO32246.1 - 0.93 8.2 33.0 1.3 7.7 33.0 1.1 1 0 0 1 1 1 0 Caldesmon BUD22 PF09073.10 ETO32246.1 - 3.8 6.7 32.6 5.4 6.2 32.6 1.3 1 0 0 1 1 1 0 BUD22 cNMP_binding PF00027.29 ETO32248.1 - 7.8e-06 25.9 0.0 1.7e-05 24.8 0.0 1.6 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain TRM13 PF05206.14 ETO32248.1 - 0.0082 15.7 0.4 0.013 15.1 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase TRM13 DUF4512 PF14975.6 ETO32248.1 - 0.23 12.2 0.7 2.2 9.1 0.1 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4512) RPEL PF02755.15 ETO32249.1 - 6.1e-05 22.6 1.3 0.11 12.2 0.9 2.5 2 0 0 2 2 2 2 RPEL repeat DUF1825 PF08855.10 ETO32249.1 - 0.14 12.0 2.0 1.4 8.9 0.1 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1825) HR1 PF02185.16 ETO32249.1 - 3.5 7.8 13.9 14 5.9 8.6 3.1 2 1 0 2 2 2 0 Hr1 repeat MRP-S26 PF14943.6 ETO32249.1 - 4.3 7.2 18.0 0.16 11.9 8.7 2.2 2 0 0 2 2 2 0 Mitochondrial ribosome subunit S26 DUF572 PF04502.13 ETO32250.1 - 0.81 9.3 10.8 0.3 10.7 4.9 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF572) PCI PF01399.27 ETO32253.1 - 3.4e-06 27.5 2.4 0.21 12.1 0.0 3.3 3 0 0 3 3 3 2 PCI domain DUF4193 PF13834.6 ETO32253.1 - 0.018 15.5 0.2 1.9 9.0 0.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4193) TPR_2 PF07719.17 ETO32253.1 - 0.17 12.1 0.1 0.43 10.8 0.1 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Lactamase_B_2 PF12706.7 ETO32255.1 - 2.5e-11 43.5 0.3 0.00021 20.9 0.0 3.0 2 1 1 3 3 3 2 Beta-lactamase superfamily domain Lactamase_B PF00753.27 ETO32255.1 - 2.6e-05 24.3 0.1 3.5e-05 23.9 0.1 1.3 1 0 0 1 1 1 1 Metallo-beta-lactamase superfamily Lactamase_B_4 PF13691.6 ETO32255.1 - 0.00088 18.9 0.0 0.0016 18.1 0.0 1.4 1 0 0 1 1 1 1 tRNase Z endonuclease HP0268 PF18618.1 ETO32258.1 - 0.018 15.5 2.5 0.048 14.1 2.5 1.7 1 0 0 1 1 1 0 HP0268 NYD-SP28_assoc PF14775.6 ETO32259.1 - 0.13 12.4 0.1 0.21 11.7 0.1 1.4 1 0 0 1 1 1 0 Sperm tail C-terminal domain Herpes_UL6 PF01763.16 ETO32260.1 - 0.063 11.8 3.1 0.09 11.3 3.1 1.2 1 0 0 1 1 1 0 Herpesvirus UL6 like Tropomyosin_1 PF12718.7 ETO32260.1 - 0.067 13.3 2.5 0.17 12.0 2.5 1.7 1 0 0 1 1 1 0 Tropomyosin like Macoilin PF09726.9 ETO32260.1 - 0.36 9.3 16.9 0.41 9.1 16.9 1.1 1 0 0 1 1 1 0 Macoilin family Hamartin PF04388.12 ETO32260.1 - 0.87 8.2 15.5 1 8.0 15.5 1.0 1 0 0 1 1 1 0 Hamartin protein SOBP PF15279.6 ETO32260.1 - 8.4 6.9 13.9 10 6.6 13.9 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein G-alpha PF00503.20 ETO32261.1 - 3.2e-11 43.0 0.6 4.6e-11 42.5 0.6 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Rad17 PF03215.15 ETO32261.1 - 0.00015 21.7 0.4 0.00025 21.0 0.4 1.3 1 0 0 1 1 1 1 Rad17 P-loop domain NB-ARC PF00931.22 ETO32261.1 - 0.0019 17.4 0.2 0.0027 16.9 0.2 1.2 1 0 0 1 1 1 1 NB-ARC domain NCA2 PF08637.10 ETO32261.1 - 0.0061 15.8 0.0 0.0089 15.2 0.0 1.1 1 0 0 1 1 1 1 ATP synthase regulation protein NCA2 MtlR PF05068.12 ETO32261.1 - 0.017 15.1 0.4 0.033 14.2 0.4 1.4 1 0 0 1 1 1 0 Mannitol repressor DUF4735 PF15882.5 ETO32261.1 - 0.033 13.6 0.8 0.033 13.6 0.8 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4735) DUF2834 PF11196.8 ETO32261.1 - 0.056 13.8 0.2 0.11 12.8 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2834) ETRAMP PF09716.10 ETO32261.1 - 0.26 11.4 5.2 0.076 13.1 1.7 2.1 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Pkinase PF00069.25 ETO32262.1 - 6.9e-39 133.8 0.0 4.5e-36 124.6 0.0 2.2 1 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32262.1 - 2.1e-12 46.9 0.0 3.6e-11 42.8 0.0 2.2 1 1 0 1 1 1 1 Protein tyrosine kinase Miff PF05644.11 ETO32262.1 - 0.83 9.2 2.7 1.5 8.4 2.7 1.4 1 0 0 1 1 1 0 Mitochondrial and peroxisomal fission factor Mff Glyco_transf_49 PF13896.6 ETO32264.1 - 0.08 12.3 0.2 0.11 11.8 0.2 1.2 1 0 0 1 1 1 0 Glycosyl-transferase for dystroglycan Peptidase_S49_N PF08496.10 ETO32264.1 - 2 8.5 11.7 2.4 8.2 10.1 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Noggin PF05806.12 ETO32264.1 - 4.7 7.1 6.9 7.8 6.4 6.9 1.3 1 0 0 1 1 1 0 Noggin YMF19 PF02326.15 ETO32264.1 - 7.1 7.5 6.1 21 6.0 6.1 1.9 1 1 0 1 1 1 0 Plant ATP synthase F0 NAD_binding_2 PF03446.15 ETO32265.1 - 1.8e-31 109.5 0.1 7.6e-31 107.4 0.1 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_binding_11 PF14833.6 ETO32265.1 - 1.5e-28 99.5 0.2 2.1e-23 82.9 0.0 2.3 2 0 0 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase AIRS PF00586.24 ETO32265.1 - 0.045 14.4 0.2 0.17 12.6 0.1 2.0 2 0 0 2 2 2 0 AIR synthase related protein, N-terminal domain Ribosomal_L7Ae PF01248.26 ETO32267.1 - 0.0087 15.8 0.1 0.69 9.7 0.0 2.5 3 0 0 3 3 3 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family Auto_anti-p27 PF06677.12 ETO32267.1 - 0.14 12.3 0.5 0.27 11.4 0.5 1.5 1 0 0 1 1 1 0 Sjogren's syndrome/scleroderma autoantigen 1 (Autoantigen p27) DUF4407 PF14362.6 ETO32267.1 - 3.9 6.7 7.2 6 6.1 7.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MutS_V PF00488.21 ETO32268.1 - 2.9e-29 102.5 0.8 4.1e-29 102.0 0.8 1.2 1 0 0 1 1 1 1 MutS domain V AAA_29 PF13555.6 ETO32268.1 - 0.0091 15.7 0.0 0.016 15.0 0.0 1.3 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO32268.1 - 0.12 12.9 0.1 0.21 12.1 0.1 1.3 1 0 0 1 1 1 0 AAA domain CIAPIN1 PF05093.13 ETO32269.1 - 0.023 15.2 0.3 4.6 7.8 0.1 2.5 2 0 0 2 2 2 0 Cytokine-induced anti-apoptosis inhibitor 1, Fe-S biogenesis DUF3349 PF11829.8 ETO32269.1 - 0.041 14.6 0.2 2.9 8.7 0.0 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF3349) FPL PF09758.9 ETO32269.1 - 0.077 13.0 1.7 6.3 6.8 0.2 3.1 1 1 2 3 3 3 0 Uncharacterised conserved protein Synaptonemal_3 PF15191.6 ETO32269.1 - 0.086 12.6 1.5 0.52 10.1 0.4 2.6 2 1 0 2 2 2 0 Synaptonemal complex central element protein 3 PYST-C1 PF09690.10 ETO32269.1 - 0.098 12.4 1.7 0.37 10.6 1.7 2.0 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) DUF769 PF05590.11 ETO32270.1 - 0.014 14.8 0.8 0.019 14.4 0.8 1.1 1 0 0 1 1 1 0 Xylella fastidiosa protein of unknown function (DUF769) WD40 PF00400.32 ETO32271.1 - 1.4e-35 120.7 27.8 8.9e-07 29.5 0.7 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32271.1 - 7e-16 58.3 0.8 0.00093 19.5 0.0 6.0 5 1 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32271.1 - 8.8e-07 27.9 7.9 0.28 9.8 0.2 5.4 1 1 6 7 7 7 4 Nucleoporin Nup120/160 Pkinase PF00069.25 ETO32272.1 - 2.2e-28 99.3 0.1 2.4e-27 95.9 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32272.1 - 8.2e-15 54.8 0.0 9.1e-09 35.0 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO32272.1 - 0.026 13.9 0.0 0.049 13.0 0.0 1.4 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO32272.1 - 0.029 14.3 0.0 0.043 13.7 0.0 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family Pkinase_fungal PF17667.1 ETO32272.1 - 0.067 11.9 0.1 0.13 11.1 0.0 1.4 1 1 0 1 1 1 0 Fungal protein kinase zf-MIZ PF02891.20 ETO32273.1 - 1.9e-15 56.3 1.8 4.9e-15 55.0 1.8 1.7 1 0 0 1 1 1 1 MIZ/SP-RING zinc finger C1_2 PF03107.16 ETO32273.1 - 3.5 8.0 7.5 18 5.7 0.2 2.7 2 0 0 2 2 2 0 C1 domain Myotub-related PF06602.14 ETO32275.1 - 7.3e-34 117.2 2.7 1.8e-24 86.4 2.1 2.1 1 1 1 2 2 2 2 Myotubularin-like phosphatase domain Nucleocapsid-N PF11030.8 ETO32275.1 - 2.3 8.2 20.5 3.5 7.5 20.5 1.2 1 0 0 1 1 1 0 Nucleocapsid protein N ERM PF00769.19 ETO32275.1 - 4.5 7.0 9.7 6.8 6.4 9.7 1.2 1 0 0 1 1 1 0 Ezrin/radixin/moesin family E1-E2_ATPase PF00122.20 ETO32276.1 - 0.07 12.7 1.5 5.3 6.5 0.0 2.1 1 1 1 2 2 2 0 E1-E2 ATPase TMEM247 PF15444.6 ETO32276.1 - 0.19 11.8 3.0 0.34 10.9 3.0 1.4 1 0 0 1 1 1 0 Transmembrane protein 247 Borrelia_P83 PF05262.11 ETO32277.1 - 0.00021 20.0 4.0 0.00021 20.0 4.0 2.0 1 1 1 2 2 2 1 Borrelia P83/100 protein DUF5338 PF17273.2 ETO32279.1 - 0.02 15.0 0.9 0.039 14.0 0.9 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5338) INCENP_ARK-bind PF03941.15 ETO32280.1 - 1.6e-14 53.6 0.1 4.7e-14 52.1 0.1 1.9 1 0 0 1 1 1 1 Inner centromere protein, ARK binding region Laminin_G_3 PF13385.6 ETO32281.1 - 4.9e-15 56.0 0.3 1.5e-14 54.4 0.3 1.9 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily DUF4983 PF16356.5 ETO32281.1 - 0.032 15.0 0.1 0.76 10.6 0.0 3.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4983) Gemini_AL2 PF01440.16 ETO32283.1 - 0.019 15.4 0.0 0.048 14.1 0.0 1.6 1 0 0 1 1 1 0 Geminivirus AL2 protein CRA PF06589.11 ETO32283.1 - 0.16 12.0 6.9 0.084 13.0 4.5 1.9 1 1 1 2 2 2 0 Circumsporozoite-related antigen (CRA) ETRAMP PF09716.10 ETO32283.1 - 6.5 6.9 8.2 0.47 10.5 1.5 2.5 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Tim44 PF04280.15 ETO32284.1 - 7.8e-17 61.7 0.1 8.8e-17 61.6 0.1 1.0 1 0 0 1 1 1 1 Tim44-like domain DUF3291 PF11695.8 ETO32285.1 - 0.041 13.5 0.3 0.041 13.5 0.3 1.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3291) DUF3398 PF11878.8 ETO32285.1 - 0.096 13.1 1.8 0.26 11.8 1.8 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF3398) DUF1564 PF07600.11 ETO32286.1 - 0.026 14.2 0.3 0.049 13.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1564) WD40 PF00400.32 ETO32291.1 - 7.7e-15 55.0 0.2 1.6e-05 25.6 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat PI3_PI4_kinase PF00454.27 ETO32291.1 - 6.4e-09 36.0 6.2 1.7e-05 24.7 0.5 3.1 2 1 1 4 4 4 2 Phosphatidylinositol 3- and 4-kinase ANAPC4_WD40 PF12894.7 ETO32291.1 - 0.00014 22.1 0.0 0.026 14.8 0.0 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO32292.1 - 1.4e-20 73.2 4.2 6.6e-05 23.6 0.0 4.8 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO32292.1 - 2.6e-05 23.1 1.3 0.94 8.0 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32292.1 - 9.2e-05 22.7 0.5 0.36 11.2 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain LydB PF16084.5 ETO32292.1 - 0.0031 17.4 0.1 0.034 14.0 0.0 2.1 1 1 1 2 2 2 1 LydA-holin antagonist WD40_like PF17005.5 ETO32292.1 - 0.0033 16.8 1.0 0.039 13.3 0.1 2.2 1 1 1 2 2 2 2 WD40-like domain BBS2_Mid PF14783.6 ETO32292.1 - 0.0097 15.9 0.8 0.066 13.3 0.1 2.3 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region SH3_13 PF18335.1 ETO32292.1 - 0.024 14.5 0.3 0.18 11.7 0.0 2.4 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain Ricin_B_lectin PF00652.22 ETO32292.1 - 0.046 14.0 1.3 0.18 12.1 0.1 2.2 1 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain DUF4979 PF16351.5 ETO32292.1 - 0.1 12.8 2.2 12 6.0 0.1 2.9 1 1 1 3 3 3 0 Domain of unknown function (DUF4979) COX5B PF01215.19 ETO32292.1 - 0.15 11.8 0.1 1 9.0 0.0 2.1 2 0 0 2 2 2 0 Cytochrome c oxidase subunit Vb Skp1 PF01466.19 ETO32293.1 - 0.051 13.7 0.1 2 8.6 0.0 2.3 2 0 0 2 2 2 0 Skp1 family, dimerisation domain zf-TRAF PF02176.18 ETO32294.1 - 2.8e-06 27.9 9.8 6.3e-06 26.8 8.6 2.4 1 1 0 1 1 1 1 TRAF-type zinc finger VWA_2 PF13519.6 ETO32295.1 - 1.1e-10 42.1 0.0 2.7e-10 40.8 0.0 1.6 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA PF00092.28 ETO32295.1 - 1.1e-07 32.3 0.0 1.4e-05 25.4 0.0 2.8 1 1 1 2 2 2 2 von Willebrand factor type A domain VWA_3 PF13768.6 ETO32295.1 - 0.017 15.1 0.1 0.052 13.5 0.1 1.8 1 1 0 1 1 1 0 von Willebrand factor type A domain Glyco_hydro_49 PF03718.13 ETO32295.1 - 0.18 11.8 1.1 0.7 9.9 0.1 2.3 2 0 0 2 2 2 0 Glycosyl hydrolase family 49 WW_FCH_linker PF16623.5 ETO32296.1 - 0.52 11.1 0.1 0.52 11.1 0.1 2.7 3 0 0 3 3 3 0 Unstructured linker region between on GAS7 protein adh_short PF00106.25 ETO32297.1 - 4.7e-28 98.0 0.7 2e-18 66.6 0.3 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO32297.1 - 2.1e-18 66.8 0.0 1.9e-10 40.7 0.1 3.1 3 0 0 3 3 3 3 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO32297.1 - 0.0018 18.2 0.0 0.0065 16.4 0.0 1.9 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO32297.1 - 0.095 12.1 0.0 0.23 10.9 0.0 1.6 2 0 0 2 2 2 0 NAD dependent epimerase/dehydratase family Mito_carr PF00153.27 ETO32298.1 - 1.8e-11 43.8 0.4 6.4e-06 26.0 0.0 3.4 2 1 1 3 3 3 2 Mitochondrial carrier protein Alginate_exp PF13372.6 ETO32301.1 - 0.022 13.5 0.0 0.026 13.3 0.0 1.1 1 0 0 1 1 1 0 Alginate export DUF2325 PF10087.9 ETO32301.1 - 0.072 13.2 2.3 2.4 8.3 0.0 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2325) DASH_Dam1 PF08653.10 ETO32301.1 - 0.1 12.4 1.0 2 8.3 0.1 2.5 2 1 0 2 2 2 0 DASH complex subunit Dam1 SAM_1 PF00536.30 ETO32302.1 - 0.027 14.9 0.1 0.075 13.5 0.1 1.8 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) V_ATPase_I PF01496.19 ETO32302.1 - 2.4 6.0 7.6 0.41 8.5 1.3 2.1 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family EFG_C PF00679.24 ETO32304.1 - 5.1e-21 74.5 0.0 9.5e-21 73.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor G C-terminus EFG_IV PF03764.18 ETO32304.1 - 2.3e-18 66.1 0.0 3.8e-18 65.4 0.0 1.4 1 0 0 1 1 1 1 Elongation factor G, domain IV EFG_II PF14492.6 ETO32304.1 - 1.3e-06 28.4 0.0 2.4e-06 27.5 0.0 1.4 1 0 0 1 1 1 1 Elongation Factor G, domain II GTP_EFTU_D2 PF03144.25 ETO32304.1 - 9.9e-05 22.7 0.0 0.00047 20.5 0.0 2.1 1 1 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 ETO32305.1 - 1.7e-22 79.9 0.0 2.1e-22 79.6 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain DUF2528 PF10800.8 ETO32305.1 - 0.13 12.9 0.0 0.22 12.1 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2528) DAHP_synth_1 PF00793.20 ETO32305.1 - 0.21 10.4 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 DAHP synthetase I family Pkinase PF00069.25 ETO32306.1 - 1.5e-42 145.8 0.6 2e-41 142.1 0.6 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32306.1 - 5e-33 114.5 0.7 7.6e-33 113.9 0.7 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO32306.1 - 0.00097 18.0 2.7 0.001 18.0 1.0 1.9 2 1 0 2 2 2 1 Fungal protein kinase ANAPC15 PF15243.6 ETO32306.1 - 0.33 11.4 4.9 0.34 11.3 1.9 2.1 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 15 SBDS PF01172.18 ETO32309.1 - 1.3e-18 66.8 0.7 1.6e-18 66.5 0.7 1.1 1 0 0 1 1 1 1 Shwachman-Bodian-Diamond syndrome (SBDS) protein ECF_trnsprt PF12822.7 ETO32310.1 - 0.0015 18.6 5.1 1.3 9.1 2.9 2.8 3 0 0 3 3 3 2 ECF transporter, substrate-specific component DUF5472 PF17566.2 ETO32310.1 - 0.09 12.8 0.9 0.77 9.8 0.1 2.7 2 0 0 2 2 2 0 Family of unknown function (DUF5472) LSM14 PF12701.7 ETO32310.1 - 0.12 12.5 0.0 0.39 10.8 0.0 1.8 1 0 0 1 1 1 0 Scd6-like Sm domain DHHC PF01529.20 ETO32310.1 - 0.82 9.8 15.1 2.9 8.0 2.4 3.2 3 0 0 3 3 3 0 DHHC palmitoyltransferase DUF2569 PF10754.9 ETO32310.1 - 3.2 8.2 13.4 1.4 9.3 2.0 3.4 3 1 0 3 3 3 0 Protein of unknown function (DUF2569) LMBR1 PF04791.16 ETO32310.1 - 4.5 6.1 12.8 0.96 8.3 2.9 2.4 2 1 0 2 2 2 0 LMBR1-like membrane protein TPR_12 PF13424.6 ETO32311.1 - 9e-37 125.2 16.0 6.1e-12 45.7 0.7 4.1 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32311.1 - 9.2e-18 63.5 2.4 0.0083 16.0 0.0 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32311.1 - 1.3e-14 53.2 21.6 9e-05 22.1 1.4 5.7 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32311.1 - 2.3e-11 42.9 4.0 0.039 14.0 0.1 5.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32311.1 - 1.5e-08 34.1 15.6 0.014 15.6 0.3 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32311.1 - 3.7e-08 32.9 18.9 0.0003 20.7 0.8 5.1 5 1 0 5 5 5 3 Tetratricopeptide repeat SNAP PF14938.6 ETO32311.1 - 1.7e-06 27.7 3.5 2e-06 27.4 1.6 1.8 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO32311.1 - 0.0044 17.6 7.3 0.13 13.0 0.1 4.1 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32311.1 - 0.0045 16.6 10.8 6.4 6.6 1.7 5.9 5 1 1 6 6 6 1 TPR repeat DUF5113 PF17140.4 ETO32311.1 - 0.0062 16.4 9.5 7.2 6.4 0.1 4.3 2 2 2 4 4 4 2 Domain of unknown function (DUF5113) MIT PF04212.18 ETO32311.1 - 0.013 15.5 6.8 5.3 7.2 0.1 4.0 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO32311.1 - 0.64 9.7 7.1 2.4 7.8 1.4 2.4 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_3 PF07720.12 ETO32311.1 - 1.4 9.0 5.0 14 5.8 1.1 2.9 3 0 0 3 3 3 0 Tetratricopeptide repeat zf-TRAF PF02176.18 ETO32312.1 - 5.8e-05 23.7 0.5 5.8e-05 23.7 0.5 3.1 3 1 1 4 4 4 1 TRAF-type zinc finger LMBR1 PF04791.16 ETO32312.1 - 0.042 12.8 2.1 0.043 12.7 2.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Jnk-SapK_ap_N PF09744.9 ETO32312.1 - 0.068 13.4 14.4 1.4 9.1 12.6 2.2 2 0 0 2 2 2 0 JNK_SAPK-associated protein-1 Tho2 PF11262.8 ETO32312.1 - 0.07 12.3 9.8 0.11 11.7 9.8 1.2 1 0 0 1 1 1 0 Transcription factor/nuclear export subunit protein 2 Arena_nucleocap PF00843.17 ETO32312.1 - 0.1 11.5 3.3 0.15 10.9 3.3 1.2 1 0 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain ExsD PF16806.5 ETO32312.1 - 0.11 12.3 7.6 0.19 11.6 7.6 1.3 1 0 0 1 1 1 0 Antiactivator protein ExsD DUF2207 PF09972.9 ETO32312.1 - 0.87 8.3 5.0 1.2 7.9 5.0 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Sulfatase PF00884.23 ETO32313.1 - 1.3e-07 31.4 0.0 3.4e-06 26.7 0.0 2.6 2 1 0 2 2 2 1 Sulfatase DUF4976 PF16347.5 ETO32313.1 - 0.00022 21.4 0.0 0.044 14.0 0.1 2.4 2 0 0 2 2 2 2 Domain of unknown function (DUF4976) SecE PF00584.20 ETO32313.1 - 0.12 12.3 0.0 0.23 11.4 0.0 1.5 1 0 0 1 1 1 0 SecE/Sec61-gamma subunits of protein translocation complex DNA_pol_E_B PF04042.16 ETO32314.1 - 2.8e-16 59.5 0.0 3.7e-16 59.1 0.0 1.1 1 0 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Filament PF00038.21 ETO32315.1 - 0.0044 16.6 123.6 0.0059 16.2 6.3 5.9 4 1 1 5 5 5 3 Intermediate filament protein TPR_MLP1_2 PF07926.12 ETO32315.1 - 0.006 16.6 11.1 0.006 16.6 11.1 9.5 5 3 5 10 10 10 2 TPR/MLP1/MLP2-like protein GAS PF13851.6 ETO32315.1 - 0.0067 15.8 34.4 0.0067 15.8 34.4 7.5 4 2 2 6 6 6 2 Growth-arrest specific micro-tubule binding HJURP_C PF12347.8 ETO32315.1 - 0.0067 16.4 0.3 0.0067 16.4 0.3 4.1 4 1 1 5 5 5 1 Holliday junction regulator protein family C-terminal repeat Rootletin PF15035.6 ETO32315.1 - 0.0089 16.1 21.2 0.0089 16.1 21.2 6.8 2 1 2 5 5 5 1 Ciliary rootlet component, centrosome cohesion EzrA PF06160.12 ETO32315.1 - 0.2 9.8 122.5 0.16 10.1 44.4 4.4 3 2 0 4 4 4 0 Septation ring formation regulator, EzrA DUF4407 PF14362.6 ETO32315.1 - 0.2 11.0 98.4 0.037 13.4 5.4 5.9 1 1 5 6 6 6 0 Domain of unknown function (DUF4407) Mce4_CUP1 PF11887.8 ETO32315.1 - 1.5 8.2 36.3 0.079 12.4 1.6 4.9 4 1 1 5 5 5 0 Cholesterol uptake porter CUP1 of Mce4, putative ISG65-75 PF11727.8 ETO32317.1 - 0.0037 16.6 0.5 0.0037 16.6 0.5 1.5 2 0 0 2 2 2 1 Invariant surface glycoprotein Cyclin_N PF00134.23 ETO32318.1 - 4.1e-12 46.0 3.4 1e-09 38.2 1.0 2.5 2 0 0 2 2 2 2 Cyclin, N-terminal domain Cyclin_C PF02984.19 ETO32318.1 - 2.9e-09 37.0 3.8 1.3e-08 34.9 0.2 2.9 3 0 0 3 3 3 1 Cyclin, C-terminal domain GOLD_2 PF13897.6 ETO32318.1 - 0.1 13.1 0.0 0.22 12.0 0.0 1.5 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking DUF4685 PF15737.5 ETO32318.1 - 1.4 9.4 4.4 1.7 9.1 0.6 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4685) NAD_kinase PF01513.21 ETO32319.1 - 4.4e-13 49.1 0.0 8.8e-13 48.1 0.0 1.5 1 1 0 1 1 1 1 ATP-NAD kinase DAGK_cat PF00781.24 ETO32319.1 - 0.0063 16.1 0.1 0.0085 15.7 0.1 1.4 1 1 0 1 1 1 1 Diacylglycerol kinase catalytic domain PS_pyruv_trans PF04230.13 ETO32319.1 - 0.13 12.2 0.0 0.17 11.8 0.0 1.2 1 0 0 1 1 1 0 Polysaccharide pyruvyl transferase CitMHS PF03600.16 ETO32321.1 - 0.0028 16.9 3.0 0.54 9.4 2.7 2.3 2 0 0 2 2 2 2 Citrate transporter PsbI PF02532.14 ETO32321.1 - 0.058 13.4 0.3 0.38 10.7 0.3 2.5 1 0 0 1 1 1 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) DZR PF12773.7 ETO32321.1 - 9 6.4 13.5 55 3.9 13.8 2.0 1 1 1 2 2 2 0 Double zinc ribbon RGS PF00615.19 ETO32322.1 - 0.0046 17.2 1.2 0.034 14.4 0.2 2.4 2 0 0 2 2 2 1 Regulator of G protein signaling domain Colicin_K PF17500.2 ETO32322.1 - 0.18 12.4 5.0 12 6.5 0.1 3.3 1 1 1 2 2 2 0 Colicin-K DUF4229 PF14012.6 ETO32322.1 - 0.61 10.2 7.9 4.6 7.4 2.5 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF4229) RGS PF00615.19 ETO32323.1 - 0.064 13.5 0.2 0.064 13.5 0.2 2.5 2 1 0 2 2 2 0 Regulator of G protein signaling domain Adaptin_binding PF10199.9 ETO32324.1 - 0.0013 19.4 11.2 0.0039 17.8 11.2 1.9 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 YkuD_2 PF13645.6 ETO32324.1 - 0.023 14.1 1.8 0.042 13.3 1.8 1.5 1 0 0 1 1 1 0 L,D-transpeptidase catalytic domain Sigma70_r4_2 PF08281.12 ETO32324.1 - 0.21 11.3 3.1 4.7 7.0 0.5 2.5 1 1 1 2 2 2 0 Sigma-70, region 4 RR_TM4-6 PF06459.12 ETO32324.1 - 0.25 11.2 12.1 0.34 10.7 12.1 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 eIF-3_zeta PF05091.12 ETO32324.1 - 1.2 8.0 17.5 1.6 7.7 17.5 1.1 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3) SOBP PF15279.6 ETO32324.1 - 1.3 9.5 34.5 1.9 9.0 34.5 1.2 1 0 0 1 1 1 0 Sine oculis-binding protein PAT1 PF09770.9 ETO32324.1 - 1.4 7.1 39.3 1.6 6.9 39.3 1.0 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 ALMT PF11744.8 ETO32324.1 - 2.3 7.0 10.2 2.8 6.7 10.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Exonuc_VII_L PF02601.15 ETO32324.1 - 8.2 5.9 16.9 11 5.4 16.9 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit CSG2 PF16965.5 ETO32324.1 - 9 5.1 12.7 11 4.8 11.9 1.5 1 1 0 1 1 1 0 Ceramide synthase regulator GAS PF13851.6 ETO32328.1 - 0.0056 16.1 25.3 0.0056 16.1 25.3 1.9 1 1 1 2 2 2 1 Growth-arrest specific micro-tubule binding Hemerythrin PF01814.23 ETO32328.1 - 0.039 14.6 8.2 0.061 13.9 8.2 1.3 1 0 0 1 1 1 0 Hemerythrin HHE cation binding domain DUF4164 PF13747.6 ETO32328.1 - 0.17 12.2 17.1 0.089 13.1 5.3 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4164) Fib_alpha PF08702.10 ETO32328.1 - 0.56 10.4 18.7 0.34 11.1 2.1 2.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Spc7 PF08317.11 ETO32328.1 - 0.84 8.5 29.3 0.072 12.0 7.5 2.0 1 1 1 2 2 2 0 Spc7 kinetochore protein GlcNAc-1_reg PF18440.1 ETO32328.1 - 0.91 9.8 9.3 0.17 12.1 2.9 2.4 1 1 2 3 3 3 0 Putative GlcNAc-1 phosphotransferase regulatory domain NPV_P10 PF05531.12 ETO32328.1 - 1.5 9.3 13.0 1 9.9 4.6 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein FliD_N PF02465.18 ETO32328.1 - 1.8 9.3 11.7 0.46 11.2 0.5 2.4 1 1 1 2 2 2 0 Flagellar hook-associated protein 2 N-terminus THOC7 PF05615.13 ETO32328.1 - 2.2 8.6 22.8 3.6 7.9 8.1 2.2 1 1 1 2 2 2 0 Tho complex subunit 7 DUF4407 PF14362.6 ETO32328.1 - 2.2 7.5 13.4 3.1 7.1 13.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KR PF08659.10 ETO32328.1 - 2.3 8.1 3.9 1.4 8.8 0.8 1.9 1 1 1 2 2 2 0 KR domain SYCE1 PF15233.6 ETO32328.1 - 2.5 8.2 28.7 0.49 10.4 23.8 1.9 1 1 1 2 2 2 0 Synaptonemal complex central element protein 1 V_ATPase_I PF01496.19 ETO32328.1 - 3.3 5.5 18.0 4.9 5.0 18.0 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HD_3 PF13023.6 ETO32328.1 - 3.7 7.5 14.7 60 3.5 14.7 2.0 1 1 0 1 1 1 0 HD domain DUF4337 PF14235.6 ETO32328.1 - 5.4 7.1 20.0 0.29 11.2 7.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4337) Exonuc_VII_L PF02601.15 ETO32328.1 - 5.8 6.4 16.4 7.2 6.1 16.4 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit BRE1 PF08647.11 ETO32328.1 - 6.2 7.0 29.1 0.12 12.5 17.1 2.2 1 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase Arena_nucleocap PF00843.17 ETO32328.1 - 6.6 5.5 10.2 10 4.9 10.2 1.3 1 1 0 1 1 1 0 Arenavirus nucleocapsid N-terminal domain Csm1_N PF18504.1 ETO32328.1 - 8.2 6.8 29.4 0.09 13.1 3.9 3.9 1 1 3 4 4 4 0 Csm1 N-terminal domain Allexi_40kDa PF05549.11 ETO32329.1 - 0.0083 15.7 0.9 0.011 15.2 0.1 1.6 2 0 0 2 2 2 1 Allexivirus 40kDa protein RE_Alw26IDE PF09665.10 ETO32329.1 - 0.046 12.9 0.0 0.066 12.4 0.0 1.1 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) DUF2630 PF10944.8 ETO32329.1 - 0.15 12.5 1.9 0.43 11.1 0.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2630) DUF515 PF04415.12 ETO32329.1 - 5.5 5.3 6.0 3.9 5.8 4.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF515) Tmemb_170 PF10190.9 ETO32330.1 - 0.16 12.4 1.6 0.19 12.1 0.5 1.7 2 0 0 2 2 2 0 Putative transmembrane protein 170 zf-C3HC4 PF00097.25 ETO32331.1 - 0.15 12.0 1.0 0.42 10.5 1.0 1.8 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF1644 PF07800.12 ETO32331.1 - 0.17 12.0 2.7 0.33 11.0 0.3 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1644) Lipoxygenase PF00305.19 ETO32332.1 - 1.8e-05 23.4 0.0 6.8e-05 21.5 0.0 1.7 2 0 0 2 2 2 1 Lipoxygenase RXT2_N PF08595.11 ETO32332.1 - 0.59 10.2 3.1 1 9.3 3.1 1.4 1 0 0 1 1 1 0 RXT2-like, N-terminal zf-C2H2_6 PF13912.6 ETO32334.1 - 1.4e-07 31.3 1.6 2.7e-07 30.4 1.6 1.5 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_4 PF13894.6 ETO32334.1 - 0.0003 21.4 0.9 0.00078 20.1 0.9 1.7 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2_jaz PF12171.8 ETO32334.1 - 0.0016 18.7 0.0 0.0039 17.4 0.0 1.7 1 0 0 1 1 1 1 Zinc-finger double-stranded RNA-binding zf-C2H2 PF00096.26 ETO32334.1 - 0.0027 18.1 1.0 0.007 16.8 1.0 1.8 1 0 0 1 1 1 1 Zinc finger, C2H2 type FYDLN_acid PF09538.10 ETO32334.1 - 0.027 15.1 0.5 0.078 13.7 0.5 1.8 1 1 0 1 1 1 0 Protein of unknown function (FYDLN_acid) zf-H2C2_2 PF13465.6 ETO32334.1 - 0.028 14.8 0.6 0.075 13.5 0.6 1.7 1 0 0 1 1 1 0 Zinc-finger double domain zf-C2HC_2 PF13913.6 ETO32334.1 - 0.1 12.5 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 zinc-finger of a C2HC-type Tox-SHH PF15652.6 ETO32334.1 - 1.6 9.7 5.0 0.57 11.2 0.2 2.6 2 1 1 3 3 3 0 HNH/Endo VII superfamily toxin with a SHH signature B PF02216.16 ETO32336.1 - 0.036 14.1 3.7 0.12 12.4 0.5 2.5 2 0 0 2 2 2 0 B domain zf-RanBP PF00641.18 ETO32337.1 - 9.4e-11 40.8 9.9 4.9e-08 32.2 0.9 2.8 2 0 0 2 2 2 2 Zn-finger in Ran binding protein and others SOBP PF15279.6 ETO32337.1 - 0.012 16.2 15.3 0.012 16.2 15.3 2.5 3 0 0 3 3 3 0 Sine oculis-binding protein PHD_4 PF16866.5 ETO32337.1 - 0.62 10.2 6.1 7.4 6.7 0.2 3.4 3 0 0 3 3 3 0 PHD-finger Cytochrom_c3_2 PF14537.6 ETO32337.1 - 0.63 10.6 5.4 22 5.6 2.1 3.0 2 0 0 2 2 2 0 Cytochrome c3 PAP_central PF04928.17 ETO32338.1 - 2.7e-32 111.7 1.0 5.9e-30 104.1 0.7 2.2 2 0 0 2 2 2 2 Poly(A) polymerase central domain NTP_transf_2 PF01909.23 ETO32338.1 - 2.2e-05 24.6 0.0 4.6e-05 23.6 0.0 1.5 1 0 0 1 1 1 1 Nucleotidyltransferase domain DUF1097 PF06496.11 ETO32338.1 - 0.034 14.3 0.4 0.055 13.6 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1097) PAX PF00292.18 ETO32338.1 - 0.13 12.2 0.0 0.23 11.4 0.0 1.4 1 0 0 1 1 1 0 'Paired box' domain HNF_C PF09354.10 ETO32339.1 - 0.008 17.2 0.0 0.018 16.1 0.0 1.6 1 0 0 1 1 1 1 HNF3 C-terminal domain WD40 PF00400.32 ETO32340.1 - 3.7e-12 46.5 2.0 0.00014 22.5 0.0 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat NanE PF04131.14 ETO32341.1 - 0.081 12.1 0.0 0.15 11.2 0.0 1.5 2 0 0 2 2 2 0 Putative N-acetylmannosamine-6-phosphate epimerase Med7 PF05983.11 ETO32342.1 - 0.058 13.5 0.2 0.077 13.1 0.2 1.1 1 0 0 1 1 1 0 MED7 protein DUF3527 PF12043.8 ETO32342.1 - 0.1 12.1 0.1 0.12 12.0 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3527) NB-ARC PF00931.22 ETO32344.1 - 5.3e-06 25.8 0.5 0.002 17.3 0.0 2.1 2 0 0 2 2 2 2 NB-ARC domain NACHT PF05729.12 ETO32344.1 - 6.8e-05 22.8 0.0 0.00015 21.8 0.0 1.6 2 0 0 2 2 2 1 NACHT domain AAA_16 PF13191.6 ETO32344.1 - 0.0006 20.2 0.0 0.059 13.7 0.0 2.1 2 0 0 2 2 2 1 AAA ATPase domain PRK PF00485.18 ETO32344.1 - 0.012 15.4 0.1 0.48 10.1 0.0 2.1 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 ETO32344.1 - 0.013 15.8 0.3 0.41 10.9 0.0 2.1 1 1 1 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO32344.1 - 0.033 14.6 0.2 2 8.9 0.0 2.5 2 1 0 2 2 2 0 RNA helicase SMC_N PF02463.19 ETO32344.1 - 0.046 13.1 0.1 0.09 12.2 0.1 1.6 1 1 0 1 1 1 0 RecF/RecN/SMC N terminal domain Mg_chelatase PF01078.21 ETO32344.1 - 0.12 11.8 0.0 0.35 10.2 0.0 1.7 2 0 0 2 2 2 0 Magnesium chelatase, subunit ChlI RCC1 PF00415.18 ETO32346.1 - 3e-20 72.6 4.4 2e-07 31.5 0.1 4.5 4 0 0 4 4 4 3 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO32346.1 - 2.7e-09 36.6 20.3 2.6e-05 23.9 2.2 3.7 4 0 0 4 4 4 2 Regulator of chromosome condensation (RCC1) repeat DEP PF00610.21 ETO32346.1 - 2.6e-05 24.2 0.0 9.3e-05 22.4 0.0 2.0 1 1 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Secretin_N_2 PF07655.13 ETO32346.1 - 1.4 9.6 13.7 3.2 8.4 13.7 1.6 1 0 0 1 1 1 0 Secretin N-terminal domain DUF4834 PF16118.5 ETO32346.1 - 9.3 7.3 7.4 2.6 9.1 2.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Mucin PF01456.17 ETO32349.1 - 7.5 6.5 7.4 16 5.5 7.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein PRMT5 PF05185.16 ETO32351.1 - 6.6e-53 179.1 0.0 1.1e-52 178.3 0.0 1.3 1 0 0 1 1 1 1 PRMT5 arginine-N-methyltransferase PRMT5_C PF17286.2 ETO32351.1 - 3.6e-43 147.5 3.4 7.4e-43 146.5 3.4 1.5 1 0 0 1 1 1 1 PRMT5 oligomerisation domain PRMT5_TIM PF17285.2 ETO32351.1 - 6.3e-18 64.9 0.1 3.2e-12 46.2 0.0 2.6 2 0 0 2 2 2 2 PRMT5 TIM barrel domain BRF1 PF07741.13 ETO32351.1 - 4.1 7.8 12.4 1.9 8.9 8.1 2.2 2 0 0 2 2 2 0 Brf1-like TBP-binding domain FAM176 PF14851.6 ETO32351.1 - 4.8 6.8 9.8 12 5.6 5.2 2.2 2 0 0 2 2 2 0 FAM176 family Herpes_PAP PF03325.13 ETO32352.1 - 0.11 12.1 3.4 0.21 11.2 3.4 1.4 1 0 0 1 1 1 0 Herpesvirus polymerase accessory protein Vma12 PF11712.8 ETO32352.1 - 1.2 9.2 6.7 0.13 12.3 0.6 2.5 2 0 0 2 2 2 0 Endoplasmic reticulum-based factor for assembly of V-ATPase NAD_binding_11 PF14833.6 ETO32354.1 - 1.1e-32 112.9 0.0 5.6e-22 78.3 0.0 2.3 1 1 1 2 2 2 2 NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase NAD_binding_2 PF03446.15 ETO32354.1 - 1.1e-22 80.9 0.5 5.5e-22 78.6 0.5 1.9 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase Cadherin_tail PF15974.5 ETO32354.1 - 0.18 12.2 0.4 0.34 11.2 0.4 1.5 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region F-box-like PF12937.7 ETO32355.1 - 0.041 13.8 0.1 0.3 11.0 0.0 2.2 2 0 0 2 2 2 0 F-box-like Egg_lysin PF01303.17 ETO32355.1 - 0.082 13.1 0.1 0.22 11.7 0.2 1.7 2 0 0 2 2 2 0 Egg lysin (Sperm-lysin) HSCB_C PF07743.13 ETO32357.1 - 0.24 11.9 4.0 0.38 11.3 0.5 3.0 3 0 0 3 3 3 0 HSCB C-terminal oligomerisation domain Sigma70_ner PF04546.13 ETO32357.1 - 2.2 8.1 8.6 0.2 11.5 1.8 2.3 2 1 0 2 2 2 0 Sigma-70, non-essential region PHD PF00628.29 ETO32358.1 - 8.8e-08 31.9 6.7 3.3e-07 30.1 6.7 2.0 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETO32358.1 - 9.9e-06 25.0 7.1 1.5e-05 24.5 3.2 2.4 2 0 0 2 2 2 1 PHD-finger FANCL_C PF11793.8 ETO32358.1 - 0.0043 17.2 2.2 0.0095 16.1 2.2 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_2 PF13639.6 ETO32358.1 - 0.52 10.7 5.6 0.98 9.8 5.6 1.4 1 0 0 1 1 1 0 Ring finger domain Kelch_6 PF13964.6 ETO32360.1 - 1.3e-08 34.8 3.0 0.0016 18.7 0.1 4.4 4 1 1 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO32360.1 - 2.1e-07 30.8 1.6 4.2e-06 26.7 0.0 3.4 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO32360.1 - 8.2e-06 25.7 2.6 0.33 11.0 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO32360.1 - 1.2e-05 25.5 0.1 0.0058 16.9 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO32360.1 - 0.00014 21.4 0.1 0.23 11.1 0.0 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO32360.1 - 0.0049 16.8 5.8 0.48 10.5 0.1 4.0 5 0 0 5 5 5 2 Kelch motif N_Asn_amidohyd PF14736.6 ETO32360.1 - 0.015 14.5 0.1 0.71 9.0 0.0 2.1 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Fil_haemagg_2 PF13332.6 ETO32361.1 - 2.9e-11 43.8 78.1 0.0007 19.8 5.3 9.6 3 2 4 8 8 8 5 Hemagglutinin repeat TRADD_N PF09034.10 ETO32361.1 - 0.71 9.9 12.4 0.76 9.9 0.5 3.9 3 0 0 3 3 3 0 TRADD, N-terminal domain Phage_spike PF18715.1 ETO32361.1 - 0.98 9.5 5.4 0.43 10.7 0.8 3.0 2 0 0 2 2 2 0 Phage spike trimer FAM76 PF16046.5 ETO32362.1 - 0.12 11.7 10.2 0.17 11.2 10.2 1.2 1 0 0 1 1 1 0 FAM76 protein Atg14 PF10186.9 ETO32362.1 - 0.2 10.7 12.5 0.25 10.4 12.5 1.0 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Peptidase_S49_N PF08496.10 ETO32364.1 - 0.00062 19.9 15.1 0.00077 19.6 15.1 1.0 1 0 0 1 1 1 1 Peptidase family S49 N-terminal MAP17 PF15807.5 ETO32364.1 - 0.0052 17.0 8.9 0.0066 16.7 8.9 1.1 1 0 0 1 1 1 1 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Connexin PF00029.19 ETO32364.1 - 0.065 13.0 4.4 0.083 12.6 4.4 1.1 1 0 0 1 1 1 0 Connexin SID-1_RNA_chan PF13965.6 ETO32364.1 - 0.12 10.8 2.7 0.12 10.7 2.7 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 KAP PF05804.12 ETO32364.1 - 0.15 10.2 10.3 0.17 10.0 10.3 1.0 1 0 0 1 1 1 0 Kinesin-associated protein (KAP) CLN3 PF02487.17 ETO32364.1 - 0.22 10.6 2.3 0.23 10.4 2.3 1.0 1 0 0 1 1 1 0 CLN3 protein EOS1 PF12326.8 ETO32364.1 - 0.26 11.2 0.9 0.29 11.0 0.9 1.1 1 0 0 1 1 1 0 N-glycosylation protein Zip PF02535.22 ETO32364.1 - 0.26 10.5 1.0 0.28 10.3 1.0 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter O-antigen_lig PF13425.6 ETO32364.1 - 0.34 9.6 7.6 0.4 9.4 7.6 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ureide_permease PF07168.11 ETO32364.1 - 0.74 8.5 2.6 0.84 8.3 2.6 1.1 1 0 0 1 1 1 0 Ureide permease HCO3_cotransp PF00955.21 ETO32364.1 - 1.1 8.0 3.5 1.3 7.8 3.5 1.0 1 0 0 1 1 1 0 HCO3- transporter family AP3D1 PF06375.11 ETO32364.1 - 2.1 8.6 18.1 2.7 8.2 18.1 1.2 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 O_anti_polymase PF01901.16 ETO32364.1 - 2.4 7.3 4.2 3.6 6.8 4.2 1.3 1 1 0 1 1 1 0 Putative O-antigen polymerase KGK PF08872.10 ETO32364.1 - 5.6 7.5 16.7 2.4 8.7 1.2 2.1 1 1 1 2 2 2 0 KGK domain ACPS PF01648.20 ETO32365.1 - 1.4e-15 57.4 0.1 2.1e-15 56.8 0.1 1.5 1 1 0 1 1 1 1 4'-phosphopantetheinyl transferase superfamily Cdc13_OB4_dimer PF18233.1 ETO32365.1 - 0.14 12.3 0.5 4.1 7.6 0.0 2.1 2 0 0 2 2 2 0 Cdc13 OB4 dimerization domain DUF1768 PF08719.11 ETO32366.1 - 1.3e-10 41.8 2.6 1.7e-10 41.4 2.6 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF1768) Na_Ca_ex PF01699.24 ETO32368.1 - 1.2e-20 74.0 34.0 8.8e-18 64.7 16.5 2.8 2 2 0 2 2 2 2 Sodium/calcium exchanger protein Zip PF02535.22 ETO32368.1 - 2.2e-05 23.9 5.0 4e-05 23.0 5.0 1.4 1 0 0 1 1 1 1 ZIP Zinc transporter DUF1120 PF06551.12 ETO32368.1 - 0.038 14.1 0.0 0.088 13.0 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1120) Connexin PF00029.19 ETO32368.1 - 0.052 13.3 0.1 0.11 12.2 0.1 1.6 1 0 0 1 1 1 0 Connexin TRAP_alpha PF03896.16 ETO32368.1 - 0.12 11.5 0.4 0.18 11.0 0.4 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF2457 PF10446.9 ETO32368.1 - 0.45 9.6 9.6 0.62 9.1 9.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DNA_pol_phi PF04931.13 ETO32368.1 - 0.83 7.7 6.9 1.1 7.2 6.9 1.1 1 0 0 1 1 1 0 DNA polymerase phi DUF2946 PF11162.8 ETO32368.1 - 1.9 9.2 3.8 12 6.6 3.8 2.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2946) Orf78 PF06024.12 ETO32368.1 - 3.6 7.9 0.0 3.6 7.9 0.0 3.4 4 0 0 4 4 4 0 Orf78 (ac78) NPR3 PF03666.13 ETO32368.1 - 9.6 4.9 6.3 14 4.3 6.3 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 WD40 PF00400.32 ETO32370.1 - 4.7e-15 55.7 1.4 8.8e-06 26.4 0.1 6.1 6 1 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32370.1 - 7.2e-06 26.2 0.0 0.69 10.3 0.0 4.4 2 1 3 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO32370.1 - 0.035 12.9 0.7 0.41 9.3 0.4 2.5 2 1 0 3 3 3 0 Nup133 N terminal like His_Phos_1 PF00300.22 ETO32371.1 - 5.9e-12 45.7 0.2 1.4e-10 41.2 0.2 2.1 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) DUF2660 PF10859.8 ETO32371.1 - 0.063 13.8 1.8 0.15 12.6 0.3 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2660) Hexokinase_1 PF00349.21 ETO32372.1 - 0.01 15.8 0.0 0.012 15.5 0.0 1.1 1 0 0 1 1 1 0 Hexokinase TauE PF01925.19 ETO32373.1 - 6.9e-16 58.6 15.7 1.1e-15 57.9 14.1 1.8 2 0 0 2 2 2 1 Sulfite exporter TauE/SafE TraL PF07178.11 ETO32373.1 - 9.2 6.8 9.0 9.8 6.7 0.1 3.5 4 0 0 4 4 4 0 TraL protein LINES_C PF14695.6 ETO32374.1 - 5.8e-16 57.6 0.3 1.7e-15 56.1 0.3 1.8 1 0 0 1 1 1 1 Lines C-terminus LINES_N PF14694.6 ETO32374.1 - 2.9e-10 40.2 1.6 2.9e-10 40.2 1.6 2.1 2 0 0 2 2 2 1 Lines N-terminus TspO_MBR PF03073.15 ETO32375.1 - 0.0041 17.2 4.7 0.0053 16.8 4.7 1.1 1 0 0 1 1 1 1 TspO/MBR family NAP PF00956.18 ETO32375.1 - 0.015 14.5 0.7 0.019 14.2 0.7 1.1 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) DUF2207 PF09972.9 ETO32375.1 - 0.066 12.0 0.0 0.074 11.8 0.0 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) GOLD_2 PF13897.6 ETO32375.1 - 1.7 9.2 5.5 0.86 10.1 3.4 1.6 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking TMEM151 PF14857.6 ETO32376.1 - 8.2e-15 54.7 0.1 1.1e-14 54.2 0.1 1.1 1 0 0 1 1 1 1 TMEM151 family DEDD_Tnp_IS110 PF01548.17 ETO32377.1 - 0.1 12.5 0.0 0.14 12.0 0.0 1.1 1 0 0 1 1 1 0 Transposase FixQ PF05545.11 ETO32377.1 - 0.41 10.6 1.8 0.77 9.8 1.8 1.5 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ Pkinase PF00069.25 ETO32378.1 - 2.4e-63 214.0 7.4 3e-59 200.5 0.8 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32378.1 - 2.2e-38 132.0 0.1 2.5e-35 122.0 0.1 2.4 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO32378.1 - 1.5e-06 27.3 0.3 1.5e-06 27.3 0.3 2.9 2 1 1 3 3 3 1 Fungal protein kinase Kdo PF06293.14 ETO32378.1 - 0.006 16.0 1.4 0.011 15.1 0.7 1.7 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETO32378.1 - 0.022 14.3 0.5 0.022 14.3 0.5 2.1 2 0 0 2 2 2 0 RIO1 family BSP_II PF05432.11 ETO32378.1 - 0.43 10.2 33.4 0.74 9.5 11.8 3.2 3 0 0 3 3 3 0 Bone sialoprotein II (BSP-II) Tim54 PF11711.8 ETO32378.1 - 4.8 5.9 14.7 0.29 9.9 4.0 2.2 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 FAM176 PF14851.6 ETO32378.1 - 7 6.3 14.1 5.5 6.7 7.5 2.9 2 0 0 2 2 2 0 FAM176 family Anoctamin PF04547.12 ETO32379.1 - 2.1e-44 152.1 0.0 2.5e-44 151.9 0.0 1.0 1 0 0 1 1 1 1 Calcium-activated chloride channel Anoctamin PF04547.12 ETO32380.1 - 3e-48 164.8 11.2 4.3e-48 164.3 11.2 1.2 1 0 0 1 1 1 1 Calcium-activated chloride channel FTO_CTD PF12934.7 ETO32381.1 - 0.013 15.3 2.0 0.013 15.3 2.0 1.9 1 1 1 2 2 2 0 FTO C-terminal domain FlaC_arch PF05377.11 ETO32381.1 - 0.065 13.6 1.0 0.065 13.6 1.0 3.8 2 2 2 4 4 4 0 Flagella accessory protein C (FlaC) APG6_N PF17675.1 ETO32381.1 - 0.22 12.0 27.3 1.1 9.8 9.5 2.2 2 0 0 2 2 2 0 Apg6 coiled-coil region DUF1493 PF07377.12 ETO32381.1 - 0.63 10.5 5.6 0.39 11.2 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1493) CENP-F_leu_zip PF10473.9 ETO32381.1 - 1.1 9.3 29.4 6.1 6.9 10.1 3.4 1 1 0 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF2570 PF10828.8 ETO32381.1 - 6 6.7 21.2 0.058 13.2 3.1 3.5 1 1 3 4 4 4 0 Protein of unknown function (DUF2570) Cep57_CLD_2 PF14197.6 ETO32381.1 - 7.3 6.8 18.6 1 9.5 6.4 3.3 3 0 0 3 3 3 0 Centrosome localisation domain of PPC89 Nnf1 PF03980.14 ETO32381.1 - 7.4 7.0 20.9 0.59 10.5 6.2 3.6 2 2 0 2 2 2 0 Nnf1 ProQ PF04352.13 ETO32382.1 - 0.0092 15.9 3.5 0.012 15.5 0.4 2.7 2 0 0 2 2 2 1 ProQ/FINO family DUF5339 PF17274.2 ETO32382.1 - 0.07 14.0 1.9 0.07 14.0 1.9 5.7 4 2 1 5 5 5 0 Family of unknown function (DUF5339) PseudoU_synth_1 PF01416.20 ETO32383.1 - 8.2e-07 29.5 0.1 4.9e-06 27.0 0.0 2.2 2 0 0 2 2 2 1 tRNA pseudouridine synthase Apis_Csd PF11671.8 ETO32383.1 - 0.92 9.5 22.4 0.088 12.8 16.3 2.4 1 1 0 2 2 2 0 Complementary sex determiner protein YqzH PF14164.6 ETO32383.1 - 2.1 8.5 4.8 57 3.9 0.1 3.9 3 1 1 4 4 4 0 YqzH-like protein PCMT PF01135.19 ETO32385.1 - 0.09 12.5 0.1 0.17 11.6 0.0 1.5 2 0 0 2 2 2 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) WD40 PF00400.32 ETO32388.1 - 2.3e-35 120.0 15.2 7e-09 36.2 0.2 9.5 10 0 0 10 10 9 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32388.1 - 4.5e-10 39.7 1.0 0.0013 18.9 0.0 5.8 3 1 5 8 8 7 2 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO32388.1 - 2e-06 27.5 1.2 11 6.1 0.1 6.0 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO32388.1 - 5e-06 25.3 0.0 0.031 12.8 0.0 3.6 2 1 2 4 4 4 3 Cytochrome D1 heme domain Ge1_WD40 PF16529.5 ETO32388.1 - 1.1e-05 24.6 7.7 0.31 9.9 0.0 5.5 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO32388.1 - 2.5e-05 24.4 1.1 0.0024 18.1 0.2 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO32388.1 - 0.00017 21.5 0.1 0.00065 19.7 0.1 2.0 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO32388.1 - 0.0011 18.5 1.2 0.0024 17.4 0.3 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO32388.1 - 0.055 13.5 1.0 1.9 8.6 0.4 2.9 2 0 0 2 2 2 0 Kelch motif DUF4988 PF16378.5 ETO32388.1 - 0.16 11.7 6.5 1.9 8.1 0.1 3.6 3 1 0 3 3 3 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO32388.1 - 1.7 8.4 8.8 53 3.6 0.2 4.6 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Pox_Ag35 PF03286.14 ETO32390.1 - 0.034 13.9 7.3 0.048 13.5 7.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein FAM60A PF15396.6 ETO32390.1 - 0.052 13.5 4.7 0.069 13.1 4.7 1.1 1 0 0 1 1 1 0 Protein Family FAM60A CDK5_activator PF03261.15 ETO32390.1 - 0.061 12.9 4.2 0.072 12.6 4.2 1.0 1 0 0 1 1 1 0 Cyclin-dependent kinase 5 activator protein Vfa1 PF08432.10 ETO32390.1 - 0.19 12.1 10.2 0.25 11.7 10.2 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 NOA36 PF06524.12 ETO32390.1 - 0.29 10.4 7.8 0.43 9.9 7.8 1.2 1 0 0 1 1 1 0 NOA36 protein SLC12 PF03522.15 ETO32390.1 - 0.5 9.3 5.5 0.61 9.1 5.5 1.1 1 0 0 1 1 1 0 Solute carrier family 12 DUF4746 PF15928.5 ETO32390.1 - 2 7.8 9.7 2.9 7.3 9.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Paramyxo_ncap PF00973.19 ETO32390.1 - 3.2 6.5 5.8 3.6 6.4 5.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein T3SSipB PF16535.5 ETO32391.1 - 0.064 13.7 8.6 0.097 13.1 8.6 1.2 1 0 0 1 1 1 0 Type III cell invasion protein SipB DUF812 PF05667.11 ETO32391.1 - 0.1 11.4 18.9 0.14 11.0 18.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF641 PF04859.12 ETO32391.1 - 0.15 12.4 14.5 0.29 11.4 14.5 1.5 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) V_ATPase_I PF01496.19 ETO32391.1 - 0.2 9.5 5.8 0.21 9.5 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family BST2 PF16716.5 ETO32391.1 - 0.45 11.1 12.8 0.58 10.8 11.1 2.1 1 1 1 2 2 2 0 Bone marrow stromal antigen 2 LMBR1 PF04791.16 ETO32391.1 - 0.86 8.4 3.3 1.2 8.0 3.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein APG6_N PF17675.1 ETO32391.1 - 1.4 9.4 16.6 2.3 8.7 16.6 1.4 1 0 0 1 1 1 0 Apg6 coiled-coil region Exonuc_VII_L PF02601.15 ETO32391.1 - 2.8 7.4 8.7 3.7 7.0 8.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF1387 PF07139.11 ETO32391.1 - 3.8 7.1 19.4 5.6 6.6 19.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Atg14 PF10186.9 ETO32391.1 - 4.5 6.3 11.9 5.8 5.9 11.9 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF4407 PF14362.6 ETO32391.1 - 4.6 6.5 10.9 6.6 6.0 10.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Macoilin PF09726.9 ETO32391.1 - 6 5.3 11.7 8.5 4.8 11.7 1.3 1 0 0 1 1 1 0 Macoilin family FapA PF03961.13 ETO32391.1 - 8.2 4.9 11.7 12 4.3 11.7 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A OmpH PF03938.14 ETO32391.1 - 9.4 6.6 18.7 19 5.6 18.7 1.6 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) WD40 PF00400.32 ETO32392.1 - 2.5e-44 148.4 26.4 6.6e-08 33.1 1.9 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32392.1 - 8.8e-14 51.6 0.3 0.0027 18.0 0.0 5.9 5 2 2 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32392.1 - 2.5e-08 33.0 6.2 0.089 11.4 0.1 4.7 3 1 0 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32392.1 - 0.0041 16.5 12.3 0.55 9.5 0.1 5.0 3 2 4 7 7 7 4 WD40-like domain Metallophos PF00149.28 ETO32393.1 - 1.2e-22 81.4 0.0 1.6e-22 81.0 0.0 1.1 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase STPPase_N PF16891.5 ETO32393.1 - 2.1e-20 72.9 1.1 4.1e-20 71.9 1.1 1.5 1 0 0 1 1 1 1 Serine-threonine protein phosphatase N-terminal domain Flavoprotein PF02441.19 ETO32394.1 - 6.1e-38 130.0 0.1 2.6e-37 128.0 0.1 1.8 1 1 0 1 1 1 1 Flavoprotein CAP_GLY PF01302.25 ETO32395.1 - 1.6e-34 117.7 12.3 6.6e-14 51.7 0.1 3.4 3 0 0 3 3 3 3 CAP-Gly domain YajC PF02699.15 ETO32395.1 - 0.048 13.6 0.4 0.16 11.8 0.1 2.0 2 0 0 2 2 2 0 Preprotein translocase subunit CAP_GLY PF01302.25 ETO32396.1 - 4.9e-20 71.3 0.5 4.9e-20 71.3 0.5 1.8 2 0 0 2 2 2 1 CAP-Gly domain RPEL PF02755.15 ETO32396.1 - 0.00012 21.6 0.7 0.00012 21.6 0.7 2.0 2 0 0 2 2 2 1 RPEL repeat Mucin PF01456.17 ETO32397.1 - 1.4 8.9 35.5 0.065 13.2 28.3 2.2 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF1387 PF07139.11 ETO32397.1 - 3.2 7.4 12.7 6.2 6.5 12.7 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) Helicase_C PF00271.31 ETO32398.1 - 0.00073 19.9 0.2 0.017 15.5 0.0 2.8 2 0 0 2 2 2 1 Helicase conserved C-terminal domain VWA_2 PF13519.6 ETO32398.1 - 0.015 15.9 0.0 0.033 14.8 0.0 1.6 1 0 0 1 1 1 0 von Willebrand factor type A domain Peptidase_C14 PF00656.22 ETO32399.1 - 2e-10 41.1 0.4 3.3e-10 40.3 0.4 1.3 1 1 0 1 1 1 1 Caspase domain Tetraspanin PF00335.20 ETO32399.1 - 0.026 14.2 0.3 0.041 13.6 0.2 1.4 1 1 0 1 1 1 0 Tetraspanin family LIN52 PF10044.9 ETO32400.1 - 0.29 11.8 7.9 39 5.0 0.4 4.2 2 1 3 5 5 5 0 Retinal tissue protein TAF PF02969.17 ETO32402.1 - 3.9e-07 30.1 0.3 1.4e-06 28.4 0.0 2.0 2 0 0 2 2 2 1 TATA box binding protein associated factor (TAF) Ras PF00071.22 ETO32403.1 - 1.6e-45 154.6 0.1 4.5e-45 153.2 0.1 1.7 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO32403.1 - 6.9e-24 84.4 0.1 2.1e-23 82.8 0.1 1.9 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase GTP_EFTU PF00009.27 ETO32403.1 - 1.1e-05 25.1 0.1 4.6e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Arf PF00025.21 ETO32403.1 - 2.8e-05 23.6 3.5 3.5e-05 23.3 1.6 2.2 1 1 1 2 2 2 1 ADP-ribosylation factor family LptF_LptG PF03739.14 ETO32403.1 - 0.023 13.6 0.3 0.023 13.6 0.3 1.8 2 0 0 2 2 2 0 Lipopolysaccharide export system permease LptF/LptG Med30 PF11315.8 ETO32403.1 - 0.87 9.8 6.0 0.67 10.1 1.8 2.8 3 0 0 3 3 3 0 Mediator complex subunit 30 SesA PF17107.5 ETO32403.1 - 2.3 8.5 4.9 12 6.1 1.3 3.4 3 1 0 3 3 3 0 N-terminal domain on NACHT_NTPase and P-loop NTPases PABP PF00658.18 ETO32405.1 - 9.3e-07 29.0 0.0 1.5e-06 28.3 0.0 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain RRM_1 PF00076.22 ETO32406.1 - 4.9e-16 58.3 0.1 2e-06 27.5 0.0 3.4 2 1 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO32406.1 - 2.1e-07 30.8 0.0 0.00023 21.1 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif Phospholip_A2_3 PF09056.11 ETO32406.1 - 0.0046 17.6 0.4 0.018 15.7 0.4 2.0 1 0 0 1 1 1 1 Prokaryotic phospholipase A2 GFA PF04828.14 ETO32406.1 - 0.094 13.1 0.4 0.38 11.1 0.1 2.1 2 0 0 2 2 2 0 Glutathione-dependent formaldehyde-activating enzyme Pribosyltran PF00156.27 ETO32407.1 - 8.8e-10 38.3 0.0 1.6e-09 37.5 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosyl transferase domain Pribosyl_synth PF14572.6 ETO32407.1 - 2e-05 24.7 0.0 2.5e-05 24.4 0.0 1.2 1 0 0 1 1 1 1 Phosphoribosyl synthetase-associated domain HSBP1 PF06825.12 ETO32408.1 - 0.42 10.5 5.5 0.12 12.3 1.5 2.3 2 0 0 2 2 2 0 Heat shock factor binding protein 1 Corazonin PF17308.2 ETO32412.1 - 0.0037 17.6 11.9 0.0037 17.6 11.9 3.3 3 0 0 3 3 3 1 Pro-corazonin CENP-B_dimeris PF09026.10 ETO32412.1 - 0.96 9.9 19.0 0.35 11.3 6.4 2.9 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Vps26 PF03643.15 ETO32414.1 - 5.1e-104 347.1 2.3 6.1e-104 346.9 2.3 1.0 1 0 0 1 1 1 1 Vacuolar protein sorting-associated protein 26 Arrestin_C PF02752.22 ETO32414.1 - 0.00017 22.1 1.3 0.11 13.0 0.0 2.3 2 0 0 2 2 2 2 Arrestin (or S-antigen), C-terminal domain Arrestin_N PF00339.29 ETO32414.1 - 0.0018 18.3 0.5 1.1 9.3 0.0 3.2 2 1 1 3 3 3 2 Arrestin (or S-antigen), N-terminal domain TFIIA PF03153.13 ETO32415.1 - 1.4 8.8 11.9 1.5 8.8 11.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF11 PF01345.18 ETO32415.1 - 2 8.8 10.8 8.1 6.8 10.8 2.0 1 1 0 1 1 1 0 Domain of unknown function DUF11 SAYSvFN PF10260.9 ETO32416.1 - 4.2e-21 74.6 2.1 6.4e-21 74.1 2.1 1.3 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) SEC-C PF02810.15 ETO32416.1 - 0.00019 21.3 8.5 0.00029 20.7 8.5 1.3 1 0 0 1 1 1 1 SEC-C motif TarH PF02203.15 ETO32417.1 - 0.029 14.3 0.5 8.8 6.2 0.2 2.3 2 0 0 2 2 2 0 Tar ligand binding domain homologue Pectate_lyase_3 PF12708.7 ETO32418.1 - 0.076 12.8 0.0 0.13 12.1 0.0 1.4 1 0 0 1 1 1 0 Pectate lyase superfamily protein ATP-synt_ab PF00006.25 ETO32419.1 - 5.8e-07 29.4 0.1 7.8e-07 29.0 0.1 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Rtf2 PF04641.12 ETO32419.1 - 0.063 12.6 0.0 0.092 12.1 0.0 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger SNARE_assoc PF09335.11 ETO32420.1 - 0.008 16.7 0.9 0.008 16.7 0.9 2.7 3 0 0 3 3 3 1 SNARE associated Golgi protein ATP-synt_ab PF00006.25 ETO32421.1 - 1.2e-46 159.0 0.0 1.1e-45 155.9 0.0 2.0 1 1 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain zf-C2H2 PF00096.26 ETO32422.1 - 1.6e-07 31.4 26.0 0.00027 21.2 1.2 4.0 4 0 0 4 4 4 2 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO32422.1 - 4.1e-05 23.8 16.7 0.0014 19.0 0.1 4.1 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO32422.1 - 7.2e-05 23.3 22.4 0.044 14.6 0.7 4.1 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 ETO32422.1 - 0.0029 18.0 0.2 0.0029 18.0 0.2 3.6 3 1 0 3 3 3 1 Zinc-finger of C2H2 type zf-C2H2_2 PF12756.7 ETO32422.1 - 0.0085 16.4 12.1 0.089 13.1 0.2 3.3 2 1 0 2 2 2 1 C2H2 type zinc-finger (2 copies) LMBR1 PF04791.16 ETO32422.1 - 0.028 13.4 0.5 0.028 13.4 0.5 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein Sec62 PF03839.16 ETO32422.1 - 0.071 12.6 1.0 0.12 11.9 1.0 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 zf-C2H2_jaz PF12171.8 ETO32422.1 - 0.077 13.3 12.2 0.3 11.4 0.0 3.3 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zinc_ribbon_15 PF17032.5 ETO32422.1 - 0.078 13.7 1.0 0.078 13.7 1.0 3.2 2 2 1 3 3 2 0 zinc-ribbon family DDHD PF02862.17 ETO32422.1 - 0.17 12.0 8.7 1.6 8.8 3.0 2.2 2 0 0 2 2 2 0 DDHD domain Corona_nucleoca PF00937.18 ETO32422.1 - 0.49 9.4 15.6 0.75 8.8 15.6 1.2 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein zf-H2C2_5 PF13909.6 ETO32422.1 - 0.57 10.0 18.4 0.15 11.8 1.6 3.4 4 0 0 4 4 4 0 C2H2-type zinc-finger domain zf-C2H2_8 PF15909.5 ETO32422.1 - 0.92 9.8 8.6 1.8 8.9 2.7 2.5 1 1 1 2 2 2 0 C2H2-type zinc ribbon PHD PF00628.29 ETO32422.1 - 1.6 8.7 7.2 4.4 7.3 3.2 2.7 2 0 0 2 2 2 0 PHD-finger Dsh_C PF12316.8 ETO32422.1 - 2.2 8.6 10.4 2 8.8 8.5 1.8 1 1 1 2 2 2 0 Segment polarity protein dishevelled (Dsh) C terminal zf-BED PF02892.15 ETO32422.1 - 3.9 7.6 17.0 3.6 7.7 3.1 3.1 1 1 2 3 3 3 0 BED zinc finger PRP38_assoc PF12871.7 ETO32422.1 - 5 7.8 27.7 0.52 10.9 21.7 2.3 3 0 0 3 3 3 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term NPR3 PF03666.13 ETO32422.1 - 5.6 5.6 14.7 8.2 5.1 14.7 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 fn3 PF00041.21 ETO32424.1 - 0.0063 16.8 0.5 0.068 13.5 0.0 2.3 2 0 0 2 2 2 1 Fibronectin type III domain fn3_4 PF16794.5 ETO32424.1 - 0.066 13.1 0.2 0.22 11.5 0.0 2.0 2 0 0 2 2 2 0 Fibronectin-III type domain Svf1 PF08622.10 ETO32424.1 - 0.094 12.8 3.7 0.44 10.6 0.1 2.4 2 0 0 2 2 2 0 Svf1-like N-terminal lipocalin domain Dis3l2_C_term PF17877.1 ETO32424.1 - 0.1 12.9 0.9 0.29 11.5 0.0 2.1 2 0 0 2 2 2 0 DIS3-like exonuclease 2 C terminal DUF3945 PF13101.6 ETO32424.1 - 0.1 12.3 0.0 0.27 11.0 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3945) T6PP_N PF18572.1 ETO32425.1 - 0.037 13.9 1.6 0.059 13.2 1.3 1.6 2 0 0 2 2 2 0 Trehalose-6-phosphate phosphatase N-terminal helical bundle domain Flp_N PF03930.14 ETO32425.1 - 0.09 12.8 0.9 0.09 12.8 0.9 2.6 2 1 1 3 3 3 0 Recombinase Flp protein N-terminus WD40 PF00400.32 ETO32426.1 - 4.6e-38 128.5 23.5 2.8e-06 27.9 0.9 7.2 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO32426.1 - 4.9e-14 51.9 5.4 0.0025 16.6 0.1 5.0 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32426.1 - 1.7e-11 44.2 0.3 0.18 12.1 0.0 5.8 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32426.1 - 2.8e-05 23.6 8.6 0.66 9.2 0.2 4.9 2 2 2 5 5 5 4 WD40-like domain EamA PF00892.20 ETO32427.1 - 0.00013 22.1 1.3 0.00013 22.1 1.3 4.0 4 1 0 4 4 4 2 EamA-like transporter family BatD PF13584.6 ETO32427.1 - 0.078 11.8 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Oxygen tolerance Kelch_2 PF07646.15 ETO32428.1 - 0.0014 18.5 1.4 12 6.1 0.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO32428.1 - 0.03 14.6 3.7 5.1 7.5 0.0 4.1 5 0 0 5 5 5 0 Kelch motif Kelch_2 PF07646.15 ETO32429.1 - 0.0021 17.9 0.1 2.2 8.4 0.1 3.9 4 0 0 4 4 4 2 Kelch motif PUB PF09409.10 ETO32430.1 - 0.00097 19.0 0.0 0.0022 17.9 0.0 1.6 1 0 0 1 1 1 1 PUB domain MscS_TM PF12794.7 ETO32430.1 - 3.6 6.4 5.9 3.5 6.4 5.1 1.3 1 1 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 EMC3_TMCO1 PF01956.16 ETO32430.1 - 3.7 7.3 5.0 6.3 6.5 5.0 1.4 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like Pkinase PF00069.25 ETO32431.1 - 2.7e-47 161.3 0.0 8.1e-47 159.8 0.0 1.7 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32431.1 - 1.4e-16 60.5 0.0 6.1e-16 58.5 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO32431.1 - 0.00042 19.7 0.0 0.00086 18.7 0.0 1.5 1 1 0 1 1 1 1 Kinase-like VP4_haemagglut PF00426.18 ETO32432.1 - 0.00081 19.6 1.4 0.0028 17.9 1.3 1.8 2 0 0 2 2 2 1 Outer Capsid protein VP4 (Hemagglutinin) Concanavalin-like domain DUF3853 PF12964.7 ETO32432.1 - 0.058 13.6 0.2 0.23 11.7 0.0 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF3853) KMP11 PF03037.16 ETO32432.1 - 2.5 9.0 7.9 7 7.5 0.4 2.8 2 1 0 2 2 2 0 Kinetoplastid membrane protein 11 AstE_AspA PF04952.14 ETO32433.1 - 4.6e-43 147.4 0.0 6.9e-43 146.8 0.0 1.2 1 0 0 1 1 1 1 Succinylglutamate desuccinylase / Aspartoacylase family TMF_DNA_bd PF12329.8 ETO32433.1 - 0.0088 16.0 3.6 0.041 13.9 1.1 2.8 2 0 0 2 2 2 1 TATA element modulatory factor 1 DNA binding DUF4947 PF16305.5 ETO32433.1 - 0.038 14.0 0.5 0.038 14.0 0.5 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4947) FAM117 PF15388.6 ETO32433.1 - 0.25 10.8 0.0 0.25 10.8 0.0 2.4 2 0 0 2 2 2 0 Protein Family FAM117 Draxin PF15550.6 ETO32433.1 - 0.46 10.3 3.6 0.84 9.5 3.6 1.4 1 0 0 1 1 1 0 Draxin NACHT PF05729.12 ETO32434.1 - 7.5e-08 32.5 0.0 2.3e-07 30.9 0.0 1.8 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 ETO32434.1 - 4e-05 22.9 0.0 0.00013 21.2 0.0 1.8 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO32434.1 - 0.00088 19.6 0.0 0.0028 17.9 0.0 2.0 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO32434.1 - 0.0022 18.4 0.9 0.12 12.8 0.1 3.3 2 1 0 2 2 2 1 AAA ATPase domain KAP_NTPase PF07693.14 ETO32434.1 - 0.0072 15.6 0.0 0.017 14.3 0.0 1.6 1 0 0 1 1 1 1 KAP family P-loop domain AAA PF00004.29 ETO32434.1 - 0.0074 16.7 0.0 0.027 14.9 0.0 2.0 1 1 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) OTCace_N PF02729.21 ETO32434.1 - 0.011 15.7 0.0 0.025 14.6 0.0 1.5 1 0 0 1 1 1 0 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain IstB_IS21 PF01695.17 ETO32434.1 - 0.021 14.6 0.0 3.1 7.5 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_25 PF13481.6 ETO32434.1 - 0.089 12.4 0.1 2 8.0 0.0 2.2 2 0 0 2 2 2 0 AAA domain CEND1 PF15677.5 ETO32434.1 - 0.28 11.7 1.3 0.68 10.5 1.3 1.5 1 0 0 1 1 1 0 Cell cycle exit and neuronal differentiation protein 1 Smg8_Smg9 PF10220.9 ETO32434.1 - 0.93 7.7 13.7 8.2 4.6 0.1 2.1 2 0 0 2 2 2 0 Smg8_Smg9 CDC45 PF02724.14 ETO32434.1 - 1.6 6.9 18.4 3.2 5.9 18.4 1.4 1 0 0 1 1 1 0 CDC45-like protein Ribosomal_60s PF00428.19 ETO32434.1 - 6.5 7.4 12.7 0.042 14.5 3.4 2.1 2 0 0 2 2 1 0 60s Acidic ribosomal protein PDEase_I PF00233.19 ETO32435.1 - 6.2e-62 209.4 6.1 1.5e-61 208.2 6.1 1.6 1 0 0 1 1 1 1 3'5'-cyclic nucleotide phosphodiesterase GAF PF01590.26 ETO32435.1 - 3.3e-18 66.6 1.1 7.7e-07 29.8 0.1 3.6 3 0 0 3 3 3 3 GAF domain GAF_2 PF13185.6 ETO32435.1 - 7.5e-17 61.9 0.2 1.8e-07 31.5 0.0 4.6 3 2 0 3 3 3 3 GAF domain GAF_3 PF13492.6 ETO32435.1 - 5.2e-08 33.3 0.1 0.0011 19.3 0.0 4.0 4 0 0 4 4 4 2 GAF domain dCache_1 PF02743.18 ETO32435.1 - 0.00039 20.3 0.6 0.22 11.3 0.1 2.6 2 0 0 2 2 2 2 Cache domain HD PF01966.22 ETO32435.1 - 0.028 14.7 0.1 0.11 12.8 0.1 2.0 1 0 0 1 1 1 0 HD domain sCache_3_2 PF17203.4 ETO32435.1 - 0.035 14.2 0.6 9.6 6.3 0.0 3.8 4 0 0 4 4 4 0 Single cache domain 3 DUF496 PF04363.12 ETO32435.1 - 0.052 13.6 7.4 7.8 6.6 0.3 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF496) SpoVT_C PF15714.5 ETO32435.1 - 0.064 13.3 0.0 0.49 10.5 0.0 2.6 2 0 0 2 2 2 0 Stage V sporulation protein T C-terminal, transcription factor PYST-C1 PF09690.10 ETO32435.1 - 0.32 10.8 2.1 1.1 9.1 2.1 1.9 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) PT PF04886.12 ETO32436.1 - 2.7e-13 49.2 208.8 2.9e+02 1.1 14.6 9.1 1 1 2 3 3 3 0 PT repeat TMEM154 PF15102.6 ETO32436.1 - 0.0098 15.8 1.2 0.0098 15.8 1.2 3.6 2 2 3 5 5 5 1 TMEM154 protein family Orf78 PF06024.12 ETO32436.1 - 0.11 12.8 0.2 0.22 11.8 0.2 1.5 1 0 0 1 1 1 0 Orf78 (ac78) DUF2341 PF10102.9 ETO32436.1 - 1.6 9.4 3.9 2.7 8.6 1.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF2341) DUF913 PF06025.12 ETO32437.1 - 0.053 12.5 0.1 0.055 12.4 0.1 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) WD40 PF00400.32 ETO32438.1 - 5e-20 71.5 19.0 3.7e-06 27.5 0.1 6.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32438.1 - 5.1e-06 26.7 0.0 0.031 14.6 0.0 3.7 2 2 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32438.1 - 0.00025 19.9 4.1 2.7 6.5 0.4 3.9 2 2 2 4 4 4 3 Nucleoporin Nup120/160 NST1 PF13945.6 ETO32438.1 - 2.1 8.4 12.7 3.1 7.9 12.7 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator Menin PF05053.13 ETO32438.1 - 2.7 6.2 9.5 3.7 5.8 9.5 1.1 1 0 0 1 1 1 0 Menin DUF2076 PF09849.9 ETO32438.1 - 4.8 7.1 11.4 6.7 6.7 11.4 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) TPR_12 PF13424.6 ETO32439.1 - 1.2e-54 182.5 14.8 3.1e-15 56.2 2.4 4.9 4 1 2 6 6 6 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32439.1 - 2.2e-32 110.0 1.7 7e-05 22.6 0.1 6.4 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32439.1 - 2e-31 105.7 12.9 4.6e-05 23.2 0.0 7.2 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32439.1 - 1.5e-28 97.4 38.2 1.6e-05 24.5 0.1 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32439.1 - 1.2e-21 75.0 38.3 5e-05 23.2 1.0 7.8 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32439.1 - 3.9e-21 73.4 31.2 0.0012 18.8 0.5 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_17 PF13431.6 ETO32439.1 - 8.8e-11 41.4 2.6 0.84 10.2 0.2 6.5 5 1 1 6 6 6 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO32439.1 - 5.1e-08 32.7 0.0 0.0011 18.5 0.0 2.2 1 1 1 2 2 2 2 MalT-like TPR region TPR_6 PF13174.6 ETO32439.1 - 2.1e-06 28.0 0.7 16 6.4 0.0 6.4 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO32439.1 - 2.9e-06 27.6 0.1 33 5.7 0.0 6.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32439.1 - 8.1e-06 25.4 26.9 0.029 14.0 0.2 7.3 7 2 2 9 9 9 3 TPR repeat TPR_16 PF13432.6 ETO32439.1 - 9.8e-05 22.9 0.0 7.2 7.4 0.0 5.3 3 3 1 5 5 5 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO32439.1 - 0.0001 22.8 0.4 12 6.5 0.0 5.1 5 1 1 6 6 5 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO32439.1 - 0.00015 21.7 15.1 1.9 8.3 0.2 6.0 5 1 1 6 6 6 3 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 ETO32439.1 - 0.00057 19.3 11.3 1.2 8.6 0.0 5.1 5 0 0 5 5 5 2 SHNi-TPR Phage_Treg PF04761.12 ETO32439.1 - 0.02 14.9 7.1 1.1 9.4 0.2 4.8 5 0 0 5 5 5 0 Lactococcus bacteriophage putative transcription regulator DUF45 PF01863.17 ETO32439.1 - 0.042 13.9 1.4 0.91 9.5 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF45 DUF627 PF04781.12 ETO32439.1 - 0.4 10.7 5.7 1.8 8.6 0.5 3.7 3 1 1 4 4 4 0 Protein of unknown function (DUF627) HTH_Bact PF18768.1 ETO32439.1 - 0.41 10.3 21.8 9.1 6.0 2.4 6.8 6 1 0 6 6 6 0 Helix-turn-helix bacterial domain DUF4810 PF16068.5 ETO32439.1 - 0.79 10.3 8.8 24 5.6 0.0 4.8 4 1 1 6 6 5 0 Domain of unknown function (DUF4810) TPR_12 PF13424.6 ETO32440.1 - 3.3e-63 209.9 4.3 5.3e-15 55.5 0.1 6.1 4 2 1 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32440.1 - 5.5e-40 134.2 0.0 0.00017 21.3 0.1 9.3 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32440.1 - 7.8e-40 133.1 37.0 3.2e-05 23.6 3.6 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32440.1 - 1.1e-37 125.3 10.7 0.00034 20.4 0.0 9.1 9 0 0 9 9 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32440.1 - 2.6e-31 105.2 30.6 0.00012 21.9 0.0 10.2 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32440.1 - 9.4e-30 100.3 41.6 1.4e-05 24.9 0.2 9.7 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO32440.1 - 3e-15 56.4 0.0 2.2e-09 37.1 0.0 2.2 2 0 0 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 ETO32440.1 - 1.8e-14 54.1 0.0 0.67 10.6 0.0 8.3 6 2 1 8 8 8 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO32440.1 - 6.7e-14 51.2 2.3 0.34 11.4 0.1 8.3 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO32440.1 - 3e-13 49.4 0.0 6.2 7.9 0.0 8.5 9 0 0 9 9 8 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO32440.1 - 2.9e-11 43.8 0.1 6.2e-11 42.7 0.1 1.5 1 0 0 1 1 1 1 Caspase domain TPR_6 PF13174.6 ETO32440.1 - 8.3e-09 35.5 8.1 18 6.2 0.0 7.9 8 0 0 8 8 6 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32440.1 - 6.1e-08 32.2 27.3 0.25 11.0 0.0 8.5 10 0 0 10 10 8 3 TPR repeat DUF5113 PF17140.4 ETO32440.1 - 7.7e-07 29.0 9.9 4 7.2 0.1 6.6 6 1 1 7 7 7 2 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO32440.1 - 1.3e-05 25.6 4.2 3.2 8.3 0.0 6.0 5 2 2 7 7 6 1 Tetratricopeptide repeat TPR_21 PF09976.9 ETO32440.1 - 0.0015 18.3 3.8 0.17 11.6 0.0 3.3 4 0 0 4 4 3 1 Tetratricopeptide repeat-like domain DUF3856 PF12968.7 ETO32440.1 - 0.0031 17.6 5.4 0.4 10.8 0.8 3.9 2 2 1 4 4 4 1 Domain of Unknown Function (DUF3856) MIT PF04212.18 ETO32440.1 - 0.0092 16.0 20.8 1.3 9.1 0.1 6.8 7 0 0 7 7 7 2 MIT (microtubule interacting and transport) domain OrfA PF17495.2 ETO32440.1 - 0.019 15.1 0.3 20 5.4 0.0 4.2 2 1 2 4 4 4 0 Vpr-like OrfA ANAPC3 PF12895.7 ETO32440.1 - 0.034 14.4 17.5 0.79 10.0 4.2 5.7 4 2 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF627 PF04781.12 ETO32440.1 - 0.042 13.9 9.2 15 5.7 0.4 5.4 4 1 2 6 6 6 0 Protein of unknown function (DUF627) Mob_Pre PF01076.19 ETO32440.1 - 0.056 13.3 14.6 0.31 10.8 0.6 4.1 3 2 1 4 4 4 0 Plasmid recombination enzyme SHNi-TPR PF10516.9 ETO32440.1 - 0.067 12.7 0.1 0.067 12.7 0.1 4.8 6 0 0 6 6 6 0 SHNi-TPR RPN7 PF10602.9 ETO32440.1 - 0.11 12.3 15.3 5.4 6.7 1.8 5.4 2 1 3 5 5 5 0 26S proteasome subunit RPN7 TPR_3 PF07720.12 ETO32440.1 - 0.11 12.5 11.9 5.8 7.0 1.7 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF4810 PF16068.5 ETO32440.1 - 0.53 10.9 7.7 37 4.9 0.7 4.6 3 1 1 4 4 4 0 Domain of unknown function (DUF4810) DUF1955 PF09205.10 ETO32440.1 - 0.6 9.8 6.7 2.4 7.9 0.0 3.6 3 1 1 4 4 4 0 Domain of unknown function (DUF1955) HEPN PF05168.14 ETO32440.1 - 0.85 9.8 8.5 12 6.1 0.1 4.6 4 2 0 4 4 4 0 HEPN domain WD40 PF00400.32 ETO32443.1 - 4.3e-37 125.5 29.3 2.1e-06 28.3 0.3 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32443.1 - 9.1e-13 48.3 3.5 0.041 14.2 0.1 5.8 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32443.1 - 2.4e-08 33.1 7.2 0.051 12.2 0.0 5.5 3 3 2 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO32443.1 - 0.16 10.7 8.4 0.21 10.3 5.3 2.7 2 1 0 2 2 2 0 Nup133 N terminal like SprB PF13573.6 ETO32443.1 - 5.9 6.7 7.3 1.6 8.6 0.3 3.0 3 0 0 3 3 3 0 SprB repeat Thermopsin PF05317.11 ETO32444.1 - 0.01 15.3 0.2 0.018 14.5 0.1 1.4 1 1 0 1 1 1 0 Thermopsin OTU PF02338.19 ETO32445.1 - 7.5e-07 29.7 0.1 4.3e-06 27.3 0.0 2.2 2 0 0 2 2 2 1 OTU-like cysteine protease ubiquitin PF00240.23 ETO32445.1 - 0.0031 17.2 0.1 0.0094 15.7 0.1 1.9 1 1 0 1 1 1 1 Ubiquitin family zf-C2H2_2 PF12756.7 ETO32445.1 - 0.0058 16.9 0.4 0.048 14.0 0.1 2.4 3 0 0 3 3 3 1 C2H2 type zinc-finger (2 copies) DUF4710 PF15828.5 ETO32445.1 - 0.19 11.9 4.0 14 5.9 1.4 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4710) Pkinase PF00069.25 ETO32446.1 - 3.2e-42 144.7 0.0 7.3e-42 143.6 0.0 1.5 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32446.1 - 2.7e-29 102.3 0.0 3.5e-29 101.9 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO32446.1 - 0.0003 20.2 0.0 0.00078 18.8 0.0 1.6 1 1 0 1 1 1 1 Kinase-like Seadorna_VP7 PF07387.11 ETO32446.1 - 0.0029 16.7 0.2 0.043 12.9 0.0 2.4 3 0 0 3 3 3 1 Seadornavirus VP7 APH PF01636.23 ETO32446.1 - 0.0066 16.4 0.2 0.012 15.6 0.0 1.7 2 0 0 2 2 2 1 Phosphotransferase enzyme family Pox_ser-thr_kin PF05445.11 ETO32446.1 - 0.15 11.0 0.0 0.23 10.4 0.0 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase Pkinase_fungal PF17667.1 ETO32446.1 - 0.18 10.5 0.0 0.26 10.0 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Orf78 PF06024.12 ETO32447.1 - 1.7 9.0 0.0 1.7 9.0 0.0 5.2 6 1 0 6 6 6 0 Orf78 (ac78) JmjC PF02373.22 ETO32448.1 - 2.2e-34 118.3 2.6 6.1e-33 113.7 0.2 2.5 3 0 0 3 3 3 2 JmjC domain, hydroxylase PLU-1 PF08429.11 ETO32449.1 - 1.9e-11 43.8 13.7 1.1e-05 24.8 0.4 3.7 1 1 2 3 3 3 3 PLU-1-like protein Dynein_heavy PF03028.15 ETO32449.1 - 0.071 13.2 0.5 0.8 9.8 0.1 2.9 2 0 0 2 2 2 0 Dynein heavy chain region D6 P-loop domain Med9 PF07544.13 ETO32449.1 - 0.39 10.8 3.8 0.46 10.6 0.1 3.1 4 0 0 4 4 4 0 RNA polymerase II transcription mediator complex subunit 9 PDE4_UCR PF18100.1 ETO32450.1 - 0.0041 17.8 0.1 0.0041 17.8 0.1 2.9 2 1 1 3 3 3 1 Phosphodiesterase 4 upstream conserved regions (UCR) FAM76 PF16046.5 ETO32450.1 - 0.87 8.9 15.8 1.1 8.5 4.1 2.4 2 0 0 2 2 2 0 FAM76 protein DUF5308 PF17233.2 ETO32450.1 - 1 9.6 7.5 3.8 7.7 1.9 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5308) SLC12 PF03522.15 ETO32450.1 - 1.4 7.9 19.9 2.7 6.9 4.7 2.2 2 0 0 2 2 2 0 Solute carrier family 12 CPSF100_C PF13299.6 ETO32450.1 - 1.5 9.0 14.6 6.8 6.9 0.9 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal NST1 PF13945.6 ETO32450.1 - 6.4 6.8 53.4 0.22 11.6 19.0 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator Striatin PF08232.12 ETO32450.1 - 8.6 6.9 18.6 0.23 12.0 2.5 2.8 2 1 0 2 2 2 0 Striatin family Connexin PF00029.19 ETO32450.1 - 9.2 5.9 12.5 59 3.3 0.2 3.1 3 0 0 3 3 3 0 Connexin Adaptin_N PF01602.20 ETO32451.1 - 1.4e-22 80.0 0.4 1.7e-22 79.7 0.4 1.0 1 0 0 1 1 1 1 Adaptin N terminal region MecA PF05389.12 ETO32453.1 - 0.62 9.6 3.7 1.8 8.2 3.4 1.8 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) VDE PF07137.11 ETO32455.1 - 0.022 14.3 1.0 0.21 11.1 0.0 2.1 1 1 1 2 2 2 0 VDE lipocalin domain NACHT PF05729.12 ETO32456.1 - 8.3e-10 38.8 0.0 1.7e-09 37.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO32456.1 - 2e-05 25.2 0.0 0.0075 16.8 0.0 2.7 2 0 0 2 2 2 1 AAA domain RelA_SpoT PF04607.17 ETO32456.1 - 0.00016 21.9 2.2 0.00022 21.5 0.2 2.2 3 0 0 3 3 3 1 Region found in RelA / SpoT proteins AAA_22 PF13401.6 ETO32456.1 - 0.0016 18.7 0.2 0.033 14.5 0.0 3.0 3 1 0 3 3 3 1 AAA domain AAA_16 PF13191.6 ETO32456.1 - 0.0029 18.0 0.1 0.23 11.8 0.0 3.0 2 1 0 2 2 2 1 AAA ATPase domain ORF6C PF10552.9 ETO32456.1 - 0.0068 16.5 2.4 0.026 14.6 0.3 2.6 1 1 1 2 2 2 1 ORF6C domain RNA_helicase PF00910.22 ETO32456.1 - 0.011 16.1 1.1 0.15 12.4 0.1 2.9 2 1 0 2 2 2 0 RNA helicase ATP_bind_2 PF03668.15 ETO32456.1 - 0.02 14.2 0.0 0.13 11.5 0.0 2.1 2 0 0 2 2 2 0 P-loop ATPase protein family Pox_A32 PF04665.12 ETO32456.1 - 0.026 14.0 0.9 0.079 12.4 0.0 2.3 3 0 0 3 3 3 0 Poxvirus A32 protein AAA_24 PF13479.6 ETO32456.1 - 0.078 12.7 0.0 0.16 11.7 0.0 1.5 1 0 0 1 1 1 0 AAA domain TsaE PF02367.17 ETO32456.1 - 0.14 12.2 0.0 0.72 9.9 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_30 PF13604.6 ETO32456.1 - 0.2 11.4 0.0 0.69 9.6 0.0 1.8 2 0 0 2 2 2 0 AAA domain Caskin-tail PF16632.5 ETO32457.1 - 0.056 13.9 0.3 0.59 10.6 0.0 2.4 2 0 0 2 2 2 0 C-terminal region of Caskin Apo-CIII PF05778.12 ETO32457.1 - 0.15 11.7 0.0 0.31 10.7 0.0 1.5 1 0 0 1 1 1 0 Apolipoprotein CIII (Apo-CIII) WD40 PF00400.32 ETO32458.1 - 3e-42 141.8 5.7 3.2e-09 37.2 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32458.1 - 1.2e-20 73.6 0.4 0.00058 20.1 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32458.1 - 4.2e-10 39.1 0.2 0.84 8.5 0.0 4.7 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32458.1 - 3.2e-09 36.5 0.1 0.00045 19.6 0.1 2.1 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO32458.1 - 8.7e-08 32.3 0.1 0.0053 16.7 0.0 2.9 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO32458.1 - 1.8e-06 27.7 3.1 3.1 7.8 0.0 4.7 5 0 0 5 5 5 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO32458.1 - 3e-06 26.2 0.8 0.13 10.9 0.0 3.8 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO32458.1 - 9.1e-05 21.2 0.1 0.0061 15.1 0.0 1.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO32458.1 - 0.00062 18.6 0.7 1.4 7.6 0.0 3.5 1 1 2 3 3 3 3 Nup133 N terminal like PQQ_2 PF13360.6 ETO32458.1 - 0.0052 16.4 0.6 0.3 10.6 0.1 2.3 1 1 1 2 2 2 1 PQQ-like domain PQQ PF01011.21 ETO32458.1 - 0.046 13.7 0.0 0.66 10.0 0.1 2.7 3 0 0 3 3 3 0 PQQ enzyme repeat DUF4988 PF16378.5 ETO32458.1 - 0.11 12.1 0.2 3.4 7.3 0.1 2.5 2 1 1 3 3 3 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO32458.1 - 1.2 8.9 4.9 46 3.8 0.1 4.1 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature mRNA_cap_enzyme PF01331.19 ETO32460.1 - 6.7e-07 29.3 0.1 1.6e-06 28.1 0.0 1.6 2 0 0 2 2 2 1 mRNA capping enzyme, catalytic domain Methyltransf_12 PF08242.12 ETO32460.1 - 0.64 10.8 6.1 0.9 10.3 6.0 1.4 1 1 0 1 1 1 0 Methyltransferase domain Rep_fac-A_C PF08646.10 ETO32461.1 - 2e-30 105.5 0.3 2.6e-30 105.1 0.3 1.1 1 0 0 1 1 1 1 Replication factor-A C terminal domain bacHORMA_1 PF18138.1 ETO32461.1 - 0.044 13.7 0.1 0.13 12.1 0.1 1.7 2 0 0 2 2 2 0 Bacterial HORMA domain family 1 PTEN_C2 PF10409.9 ETO32461.1 - 0.048 13.4 0.2 0.11 12.2 0.1 1.5 1 1 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein Arm PF00514.23 ETO32462.1 - 0.0037 17.3 0.0 0.41 10.8 0.0 2.3 2 0 0 2 2 2 2 Armadillo/beta-catenin-like repeat DDE_3 PF13358.6 ETO32462.1 - 0.02 14.7 0.8 0.026 14.3 0.6 1.5 1 1 0 1 1 1 0 DDE superfamily endonuclease AHD PF17793.1 ETO32462.1 - 0.1 12.4 2.2 14 5.6 0.1 3.4 3 1 1 4 4 4 0 ANC1 homology domain (AHD) WD40 PF00400.32 ETO32463.1 - 6.5e-38 128.1 25.3 1.6e-08 35.1 0.2 7.2 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32463.1 - 8.6e-12 45.2 2.9 0.024 14.9 0.0 5.8 3 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32463.1 - 1.2e-11 44.0 4.8 0.028 13.1 0.2 5.8 1 1 5 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32463.1 - 1.1e-05 24.9 4.2 0.0011 18.4 0.2 3.4 2 2 3 5 5 5 3 WD40-like domain Nucleoporin_N PF08801.11 ETO32463.1 - 0.0038 16.0 11.8 0.21 10.3 0.2 4.9 1 1 0 2 2 2 2 Nup133 N terminal like NinE PF05322.11 ETO32463.1 - 0.12 12.2 6.3 46 4.0 0.0 5.0 5 0 0 5 5 5 0 NINE Protein Kelch_4 PF13418.6 ETO32464.1 - 9.3e-05 22.4 1.4 0.00025 21.0 0.3 2.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO32464.1 - 0.00033 20.8 3.2 0.082 13.2 0.2 3.6 4 0 0 4 4 4 2 Kelch motif DUF3310 PF11753.8 ETO32464.1 - 0.016 15.4 2.1 0.017 15.3 0.1 2.1 2 0 0 2 2 2 0 Protein of unknwon function (DUF3310) Kelch_1 PF01344.25 ETO32464.1 - 0.095 12.3 2.7 1.8 8.2 0.3 3.4 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO32464.1 - 0.23 11.8 1.0 3.4 8.1 0.1 3.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO32464.1 - 1.7 8.7 5.9 2.4 8.2 0.6 3.4 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO32464.1 - 2.6 8.2 9.6 15 5.7 0.3 4.0 5 1 0 5 5 5 0 Kelch motif Kelch_1 PF01344.25 ETO32465.1 - 4.9e-06 26.0 0.3 5.4e-05 22.7 0.4 2.3 2 0 0 2 2 2 1 Kelch motif DSPc PF00782.20 ETO32465.1 - 0.0003 20.6 8.6 0.00031 20.6 0.0 3.1 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Kelch_6 PF13964.6 ETO32465.1 - 0.00098 19.3 0.8 0.0092 16.2 0.2 2.6 1 1 1 2 2 2 1 Kelch motif Y_phosphatase3 PF13350.6 ETO32465.1 - 0.0018 18.3 0.1 0.0045 17.0 0.1 1.7 1 0 0 1 1 1 1 Tyrosine phosphatase family Kelch_4 PF13418.6 ETO32465.1 - 0.0042 17.1 0.9 0.012 15.7 0.2 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO32465.1 - 0.0049 16.8 0.3 0.58 10.2 0.4 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO32465.1 - 0.07 13.4 0.0 0.43 10.9 0.0 2.4 1 0 0 1 1 1 0 Galactose oxidase, central domain DUF2371 PF10177.9 ETO32465.1 - 0.27 11.4 1.9 9.4 6.4 0.1 3.0 3 0 0 3 3 3 0 Uncharacterised conserved protein (DUF2371) PTPlike_phytase PF14566.6 ETO32465.1 - 0.28 11.3 2.2 0.34 11.0 0.0 2.2 2 0 0 2 2 2 0 Inositol hexakisphosphate DUF2052 PF09747.9 ETO32465.1 - 1.4 9.1 8.4 16 5.6 4.7 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) EF-hand_8 PF13833.6 ETO32466.1 - 3.3e-06 26.8 1.2 0.036 13.9 0.0 2.7 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO32466.1 - 3.5e-06 26.2 0.0 0.015 14.8 0.0 2.3 2 0 0 2 2 2 2 EF hand EF-hand_6 PF13405.6 ETO32466.1 - 7.1e-05 22.4 0.1 0.37 10.8 0.0 2.4 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO32466.1 - 9.3e-05 22.8 0.4 0.00045 20.6 0.3 2.2 1 1 1 2 2 2 2 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO32466.1 - 0.0021 18.3 0.2 0.003 17.9 0.2 1.3 1 0 0 1 1 1 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_5 PF13202.6 ETO32466.1 - 0.0064 16.0 0.2 4.7 6.9 0.2 2.6 2 0 0 2 2 2 2 EF hand IncFII_repA PF02387.15 ETO32466.1 - 0.024 13.9 0.2 0.029 13.6 0.2 1.2 1 0 0 1 1 1 0 IncFII RepA protein family DUF3006 PF11213.8 ETO32466.1 - 0.08 13.2 0.6 0.14 12.4 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3006) DUF1420 PF07220.11 ETO32466.1 - 0.12 10.9 0.5 0.14 10.7 0.5 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1420) Protocadherin PF08374.11 ETO32467.1 - 0.00048 20.2 0.9 0.31 11.0 0.1 2.4 2 0 0 2 2 2 2 Protocadherin EphA2_TM PF14575.6 ETO32467.1 - 1.5 9.7 6.1 83 4.2 0.7 4.1 5 0 0 5 5 5 0 Ephrin type-A receptor 2 transmembrane domain LST1 PF05083.13 ETO32467.1 - 6.1 7.2 5.7 24 5.3 0.5 2.8 2 0 0 2 2 2 0 LST-1 protein G-alpha PF00503.20 ETO32468.1 - 8.5e-17 61.3 0.6 3.8e-10 39.5 0.1 2.1 2 0 0 2 2 2 2 G-protein alpha subunit AfsA PF03756.13 ETO32468.1 - 0.089 12.8 0.0 0.13 12.3 0.0 1.2 1 0 0 1 1 1 0 A-factor biosynthesis hotdog domain WD40 PF00400.32 ETO32469.1 - 6.6e-07 29.9 7.9 0.00074 20.3 0.6 4.3 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32469.1 - 0.021 15.1 0.3 0.021 15.1 0.3 2.3 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain SBDS PF01172.18 ETO32469.1 - 0.084 13.0 0.3 0.18 11.9 0.3 1.6 1 0 0 1 1 1 0 Shwachman-Bodian-Diamond syndrome (SBDS) protein TRAM_LAG1_CLN8 PF03798.16 ETO32471.1 - 4e-07 30.0 14.2 4e-07 30.0 14.2 1.7 2 0 0 2 2 2 1 TLC domain EpoR_lig-bind PF09067.10 ETO32472.1 - 1.7 8.9 8.1 0.27 11.5 3.5 2.1 2 1 0 2 2 2 0 Erythropoietin receptor, ligand binding zf-RING_2 PF13639.6 ETO32473.1 - 6.5e-07 29.6 4.9 9.5e-07 29.1 4.9 1.3 1 0 0 1 1 1 1 Ring finger domain zf-RING_UBOX PF13445.6 ETO32473.1 - 3.3e-05 23.8 5.0 5.4e-05 23.1 5.0 1.4 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4_2 PF13923.6 ETO32473.1 - 0.00065 19.5 1.8 0.0013 18.5 1.8 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) FANCL_C PF11793.8 ETO32473.1 - 0.0016 18.6 2.1 0.0035 17.5 2.1 1.6 1 0 0 1 1 1 1 FANCL C-terminal domain zf-C3HC4 PF00097.25 ETO32473.1 - 0.0036 17.1 2.4 0.0072 16.2 2.4 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-rbx1 PF12678.7 ETO32473.1 - 0.014 15.7 6.3 0.05 13.9 6.3 2.0 1 1 0 1 1 1 0 RING-H2 zinc finger domain zf-ANAPC11 PF12861.7 ETO32473.1 - 0.031 14.3 1.2 0.051 13.6 1.2 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger RINGv PF12906.7 ETO32473.1 - 0.034 14.3 4.1 0.073 13.2 4.1 1.6 1 0 0 1 1 1 0 RING-variant domain RP-C_C PF11800.8 ETO32473.1 - 0.048 13.8 0.2 0.049 13.7 0.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region zf-C3HC4_4 PF15227.6 ETO32473.1 - 0.05 13.8 1.1 0.11 12.7 1.1 1.6 1 1 0 1 1 1 0 zinc finger of C3HC4-type, RING Prok-RING_1 PF14446.6 ETO32473.1 - 0.058 13.3 1.9 0.12 12.3 1.9 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 zf-RING_11 PF17123.5 ETO32473.1 - 0.094 12.5 7.6 0.15 11.8 7.6 1.4 1 0 0 1 1 1 0 RING-like zinc finger Stevor PF17410.2 ETO32473.1 - 0.16 11.5 10.2 0.3 10.6 9.8 1.5 1 1 1 2 2 2 0 Subtelomeric Variable Open Reading frame Corazonin PF17308.2 ETO32473.1 - 0.16 12.3 9.6 0.24 11.8 9.6 1.3 1 0 0 1 1 1 0 Pro-corazonin Apis_Csd PF11671.8 ETO32473.1 - 2.9 7.9 17.6 4.7 7.2 17.6 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein UPF0715 PF17094.5 ETO32474.1 - 0.012 16.2 0.1 0.035 14.7 0.1 1.8 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0715) CCDC24 PF15669.5 ETO32474.1 - 0.39 10.5 3.6 0.8 9.5 3.6 1.6 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 24 family EST1 PF10374.9 ETO32474.1 - 0.61 10.7 7.6 1.7 9.2 5.9 2.3 1 1 1 2 2 2 0 Telomerase activating protein Est1 Tubulin_C PF03953.17 ETO32475.1 - 7.1e-25 87.6 0.0 1.7e-24 86.4 0.0 1.6 2 0 0 2 2 2 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO32475.1 - 5.1e-10 39.9 0.0 8.1e-10 39.2 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Kelch_1 PF01344.25 ETO32476.1 - 3e-06 26.7 0.2 0.0021 17.6 0.0 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO32476.1 - 6.7e-06 26.2 0.8 0.5 10.7 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO32476.1 - 2.9e-05 24.0 0.1 0.012 15.6 0.0 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO32476.1 - 0.00036 20.7 0.0 0.5 10.7 0.0 3.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO32476.1 - 0.012 15.6 0.4 1.3 9.1 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO32476.1 - 0.023 14.7 0.7 0.55 10.3 0.1 3.4 4 0 0 4 4 4 0 Kelch motif MPP6 PF10175.9 ETO32477.1 - 0.00069 20.1 33.6 0.0049 17.4 32.7 2.3 1 1 1 2 2 2 1 M-phase phosphoprotein 6 Utp14 PF04615.13 ETO32477.1 - 0.014 14.0 28.6 0.018 13.6 28.6 1.0 1 0 0 1 1 1 0 Utp14 protein UPF0227 PF05728.12 ETO32477.1 - 0.82 9.6 3.6 0.36 10.7 0.6 1.8 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0227) DUF572 PF04502.13 ETO32477.1 - 1.2 8.6 27.2 1.4 8.4 27.2 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF572) Neur_chan_memb PF02932.16 ETO32477.1 - 2.7 8.0 12.9 4.4 7.3 12.9 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CAP_C PF08603.11 ETO32478.1 - 7.8e-11 41.8 0.4 1.2e-10 41.2 0.4 1.3 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) C terminal WD40 PF00400.32 ETO32480.1 - 7.9e-38 127.8 34.1 5.8e-07 30.1 0.6 8.4 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32480.1 - 3.2e-17 62.6 0.5 0.0067 16.7 0.0 5.8 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32480.1 - 2.6e-06 26.4 8.8 0.088 11.4 0.1 4.7 3 2 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32480.1 - 0.0034 16.8 0.7 8.4 5.6 0.1 4.5 3 1 1 5 5 5 1 WD40-like domain Herpes_UL6 PF01763.16 ETO32480.1 - 0.1 11.1 2.7 0.14 10.6 2.7 1.1 1 0 0 1 1 1 0 Herpesvirus UL6 like HMMR_N PF15905.5 ETO32480.1 - 0.17 11.3 8.6 0.16 11.4 7.8 1.4 1 1 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF4201 PF13870.6 ETO32480.1 - 0.22 11.2 7.5 0.35 10.6 7.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 ETO32480.1 - 0.28 10.5 1.2 0.41 10.0 1.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CCDC14 PF15254.6 ETO32480.1 - 0.8 8.3 12.4 0.12 11.0 6.7 1.9 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 14 SR-25 PF10500.9 ETO32480.1 - 2.5 7.7 9.4 4.9 6.7 9.4 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Peptidase_M18 PF02127.15 ETO32481.1 - 2.1e-14 53.2 0.0 2.2e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 Aminopeptidase I zinc metalloprotease (M18) Tubulin_C PF03953.17 ETO32482.1 - 9.8e-42 142.1 0.1 1.7e-41 141.3 0.1 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO32482.1 - 1.3e-17 64.7 2.1 6.6e-17 62.3 0.9 2.5 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_2 PF13809.6 ETO32482.1 - 0.0037 16.5 0.0 0.0073 15.5 0.0 1.4 1 0 0 1 1 1 1 Tubulin like 2-Hacid_dh PF00389.30 ETO32482.1 - 0.084 12.5 0.1 0.18 11.4 0.0 1.5 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain EXOSC1 PF10447.9 ETO32483.1 - 5.2e-11 43.1 0.4 3e-07 31.0 0.0 2.7 2 1 1 3 3 3 2 Exosome component EXOSC1/CSL4 ECR1_N PF14382.6 ETO32483.1 - 1.3e-05 24.9 0.0 2.7e-05 23.9 0.0 1.6 1 0 0 1 1 1 1 Exosome complex exonuclease RRP4 N-terminal region RL11D PF11088.8 ETO32483.1 - 0.015 15.6 0.7 0.029 14.7 0.7 1.5 1 1 0 1 1 1 0 Glycoprotein encoding membrane proteins RL5A and RL6 PH PF00169.29 ETO32484.1 - 3.1e-12 46.9 9.4 7.3e-06 26.4 0.1 4.1 4 0 0 4 4 4 3 PH domain PH_11 PF15413.6 ETO32484.1 - 5e-06 26.9 10.0 1.5e-05 25.3 0.1 3.9 4 0 0 4 4 4 1 Pleckstrin homology domain PH_8 PF15409.6 ETO32484.1 - 0.0092 16.2 10.1 0.03 14.6 0.1 3.6 4 0 0 4 4 4 2 Pleckstrin homology domain DUF4731 PF15875.5 ETO32484.1 - 0.057 13.6 1.0 8.7 6.6 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF4731) Acp26Ab PF05777.12 ETO32485.1 - 0.025 15.2 0.0 0.049 14.3 0.0 1.4 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) Spc7 PF08317.11 ETO32486.1 - 0.00025 20.1 25.0 0.00025 20.1 25.0 1.8 1 1 1 2 2 2 1 Spc7 kinetochore protein MscS_porin PF12795.7 ETO32486.1 - 0.00029 20.5 19.2 0.00042 19.9 19.2 1.1 1 0 0 1 1 1 1 Mechanosensitive ion channel porin domain HMMR_C PF15908.5 ETO32486.1 - 0.0021 18.3 24.1 0.0032 17.8 21.0 2.3 1 1 1 2 2 2 1 Hyaluronan mediated motility receptor C-terminal DUF2894 PF11445.8 ETO32486.1 - 0.011 16.3 4.0 0.029 14.8 4.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF2894) AAA_13 PF13166.6 ETO32486.1 - 0.027 13.2 23.8 0.03 13.0 23.8 1.1 1 0 0 1 1 1 0 AAA domain DUF2968 PF11180.8 ETO32486.1 - 0.11 12.1 13.2 0.16 11.6 5.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) Glutaredoxin2_C PF04399.13 ETO32486.1 - 0.18 11.7 3.5 0.1 12.5 1.1 1.9 1 1 1 2 2 2 0 Glutaredoxin 2, C terminal domain APG6_N PF17675.1 ETO32486.1 - 0.2 12.2 31.7 1.8 9.1 15.8 2.9 1 1 2 3 3 3 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 ETO32486.1 - 0.26 12.2 32.6 0.51 11.3 12.4 3.0 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF4349 PF14257.6 ETO32486.1 - 0.39 10.1 7.1 3.1 7.2 0.8 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4349) TPR_MLP1_2 PF07926.12 ETO32486.1 - 0.68 10.0 32.3 12 6.0 21.4 2.7 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein DUF4407 PF14362.6 ETO32486.1 - 0.97 8.7 15.2 0.23 10.8 9.4 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF4407) KfrA_N PF11740.8 ETO32486.1 - 1.2 9.8 8.6 2.4 8.9 0.6 2.3 2 0 0 2 2 2 0 Plasmid replication region DNA-binding N-term DALR_2 PF09190.11 ETO32486.1 - 2.3 8.8 4.9 7.8 7.1 0.2 3.1 3 0 0 3 3 3 0 DALR domain DHquinase_II PF01220.19 ETO32486.1 - 3 7.5 6.2 3.4 7.3 1.1 2.4 1 1 1 2 2 2 0 Dehydroquinase class II DUF2400 PF09674.10 ETO32486.1 - 3.4 7.6 10.2 7.1 6.6 10.2 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF2400) Tweety PF04906.13 ETO32486.1 - 3.8 6.1 6.4 2.2 6.9 4.5 1.5 1 1 0 1 1 1 0 Tweety Methyltransf_29 PF03141.16 ETO32486.1 - 4 5.9 10.3 5 5.6 10.3 1.2 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase Prefoldin_2 PF01920.20 ETO32486.1 - 4.7 7.2 36.8 0.069 13.1 7.2 4.2 3 1 1 4 4 4 0 Prefoldin subunit DUF5344 PF17279.2 ETO32486.1 - 5.1 7.8 24.1 1.2 9.7 4.1 3.8 2 1 2 4 4 4 0 Family of unknown function (DUF5344) Flavi_NS4B PF01349.17 ETO32487.1 - 0.015 14.7 0.0 0.017 14.6 0.0 1.2 1 0 0 1 1 1 0 Flavivirus non-structural protein NS4B WD40 PF00400.32 ETO32490.1 - 2e-13 50.6 1.2 2.7e-07 31.1 0.1 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32490.1 - 1.7e-07 31.4 0.2 0.0046 17.2 0.1 2.7 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Pentapeptide_3 PF13576.6 ETO32490.1 - 0.01 16.0 0.1 0.018 15.2 0.1 1.4 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 ETO32490.1 - 0.028 14.1 0.3 0.29 10.8 0.3 2.2 1 1 0 1 1 1 0 Pentapeptide repeats (8 copies) DNA_ligase_OB PF03120.16 ETO32490.1 - 0.047 13.6 0.0 0.1 12.5 0.0 1.5 1 0 0 1 1 1 0 NAD-dependent DNA ligase OB-fold domain XPC-binding PF09280.11 ETO32491.1 - 0.025 14.3 0.3 0.073 12.8 0.1 1.8 2 0 0 2 2 2 0 XPC-binding domain DUF3194 PF11419.8 ETO32491.1 - 0.14 12.5 0.3 0.14 12.5 0.3 3.0 2 1 0 2 2 2 0 Protein of unknown function (DUF3194) Fib_alpha PF08702.10 ETO32491.1 - 0.21 11.8 5.9 0.25 11.5 4.3 1.9 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Na_Ca_ex PF01699.24 ETO32492.1 - 6.8e-16 58.6 18.8 6.8e-16 58.6 18.8 2.9 3 0 0 3 3 3 1 Sodium/calcium exchanger protein MPP6 PF10175.9 ETO32492.1 - 0.042 14.4 1.6 0.061 13.8 1.6 1.1 1 0 0 1 1 1 0 M-phase phosphoprotein 6 Iron_permease PF04120.12 ETO32492.1 - 0.98 9.2 3.5 2.6 7.8 3.5 1.8 1 0 0 1 1 1 0 Low affinity iron permease DUF4131 PF13567.6 ETO32492.1 - 3.9 7.1 10.4 20 4.8 4.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Ribosom_S12_S23 PF00164.25 ETO32493.1 - 1.1e-14 54.0 0.5 1.7e-14 53.4 0.5 1.3 1 0 0 1 1 1 1 Ribosomal protein S12/S23 DUF4798 PF16055.5 ETO32493.1 - 2.8 8.2 5.5 0.35 11.1 0.9 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4798) WD40 PF00400.32 ETO32495.1 - 1.6e-21 76.2 4.6 2e-10 41.1 0.4 2.8 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32495.1 - 1.7e-08 34.7 0.0 0.0028 17.9 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32495.1 - 1.3e-06 27.6 0.1 0.0055 15.7 0.0 2.4 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32495.1 - 0.00048 19.5 0.0 0.0011 18.4 0.0 1.5 2 0 0 2 2 2 1 WD40-like domain PD40 PF07676.12 ETO32495.1 - 0.002 18.0 0.1 0.74 9.8 0.0 2.5 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO32495.1 - 0.042 12.5 0.1 0.57 8.7 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 NCBP3 PF10309.9 ETO32495.1 - 0.062 13.2 0.7 0.14 12.0 0.7 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 WD40 PF00400.32 ETO32496.1 - 3.7e-17 62.4 4.2 4.8e-05 24.1 0.0 3.9 3 2 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32496.1 - 4.3e-05 23.7 0.1 4.5 7.6 0.0 3.1 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32496.1 - 0.0003 19.6 0.0 0.65 8.6 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO32496.1 - 0.0085 16.3 1.1 3 8.1 0.1 3.0 1 1 2 3 3 3 1 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO32497.1 - 6.4e-07 30.0 2.0 5.7e-06 27.0 0.5 2.7 2 2 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO32497.1 - 0.0076 14.9 0.1 0.0087 14.8 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 MFS_1 PF07690.16 ETO32498.1 - 2.2e-06 26.9 19.5 3.1e-05 23.1 17.5 2.0 1 1 1 2 2 2 2 Major Facilitator Superfamily Presenilin PF01080.17 ETO32499.1 - 0.085 11.6 1.0 0.099 11.4 1.0 1.1 1 0 0 1 1 1 0 Presenilin DUF4158 PF13700.6 ETO32499.1 - 0.12 12.1 0.0 0.18 11.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4158) DUF724 PF05266.14 ETO32499.1 - 4.5 7.1 10.4 9.8 5.9 10.4 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF724) Par3_HAL_N_term PF12053.8 ETO32499.1 - 5.1 7.4 7.3 20 5.5 0.9 2.3 2 0 0 2 2 2 0 N-terminal of Par3 and HAL proteins Nipped-B_C PF12830.7 ETO32500.1 - 1.2e-12 48.2 3.7 1.3e-12 48.1 1.1 2.6 2 0 0 2 2 2 1 Sister chromatid cohesion C-terminus Cohesin_HEAT PF12765.7 ETO32500.1 - 1e-07 32.1 2.7 4.9e-06 26.7 0.5 3.4 4 0 0 4 4 4 1 HEAT repeat associated with sister chromatid cohesion PHD PF00628.29 ETO32500.1 - 6.5e-05 22.7 11.6 0.00023 21.0 11.6 2.1 1 0 0 1 1 1 1 PHD-finger HEAT PF02985.22 ETO32500.1 - 0.017 15.4 0.7 5.3 7.6 0.0 5.1 5 0 0 5 5 5 0 HEAT repeat Prok-RING_1 PF14446.6 ETO32500.1 - 0.092 12.7 3.7 0.34 10.9 3.7 1.9 1 0 0 1 1 1 0 Prokaryotic RING finger family 1 OrfB_Zn_ribbon PF07282.11 ETO32500.1 - 0.11 12.4 1.5 0.53 10.3 1.5 2.2 1 0 0 1 1 1 0 Putative transposase DNA-binding domain PHD_2 PF13831.6 ETO32500.1 - 7.2 6.3 12.9 0.16 11.6 5.7 2.1 2 0 0 2 2 2 0 PHD-finger RLL PF10036.9 ETO32501.1 - 0.053 13.4 8.1 0.08 12.8 8.1 1.3 1 0 0 1 1 1 0 RNA transcription, translation and transport factor protein Anoctamin PF04547.12 ETO32502.1 - 1.3e-31 109.9 1.8 1.6e-31 109.6 1.8 1.1 1 0 0 1 1 1 1 Calcium-activated chloride channel Pox_E10 PF04805.12 ETO32502.1 - 0.054 13.4 1.3 0.76 9.7 0.1 2.7 2 0 0 2 2 2 0 E10-like protein conserved region DUF2175 PF09943.9 ETO32502.1 - 1.3 9.3 5.8 2.2 8.6 5.8 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2175) SecA_DEAD PF07517.14 ETO32503.1 - 5.2e-06 26.0 0.6 1.8e-05 24.2 0.0 2.2 2 0 0 2 2 2 1 SecA DEAD-like domain Pyr_redox_2 PF07992.14 ETO32503.1 - 0.069 12.4 0.5 0.29 10.3 0.0 2.2 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase UPF0449 PF15136.6 ETO32503.1 - 4.1 7.9 7.8 2.6 8.5 4.2 2.8 2 1 0 2 2 2 0 Uncharacterised protein family UPF0449 Anoctamin PF04547.12 ETO32504.1 - 8.9e-46 156.6 22.6 2.2e-45 155.4 22.6 1.6 1 1 0 1 1 1 1 Calcium-activated chloride channel DUF5408 PF17402.2 ETO32504.1 - 0.024 14.5 2.3 1.1 9.2 0.5 2.8 2 0 0 2 2 2 0 Family of unknown function (DUF5408) DUF2975 PF11188.8 ETO32504.1 - 0.05 13.5 0.1 0.05 13.5 0.1 2.9 3 2 0 3 3 3 0 Protein of unknown function (DUF2975) Ni_hydr_CYTB PF01292.20 ETO32504.1 - 0.25 10.9 5.7 0.25 10.9 1.4 2.3 1 1 0 2 2 2 0 Prokaryotic cytochrome b561 PH PF00169.29 ETO32505.1 - 4.2e-11 43.3 0.9 9.4e-11 42.2 0.2 1.8 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO32505.1 - 0.0066 16.7 3.2 0.05 13.9 3.2 2.2 1 1 0 1 1 1 1 Pleckstrin homology domain Cyclin_N2 PF16500.5 ETO32505.1 - 0.016 16.0 0.4 0.022 15.5 0.4 1.2 1 0 0 1 1 1 0 N-terminal region of cyclin_N Pes-10 PF07149.11 ETO32508.1 - 0.00052 19.2 3.4 0.00057 19.1 3.4 1.2 1 0 0 1 1 1 1 Pes-10 Astro_capsid_p PF12226.8 ETO32508.1 - 0.079 12.1 4.8 0.14 11.3 4.8 1.3 1 0 0 1 1 1 0 Turkey astrovirus capsid protein NHase_beta PF02211.15 ETO32508.1 - 0.093 12.7 0.0 0.14 12.2 0.0 1.2 1 0 0 1 1 1 0 Nitrile hydratase beta subunit MFS_1 PF07690.16 ETO32509.1 - 1.5e-11 43.8 2.8 4.7e-11 42.2 3.0 1.6 1 1 1 2 2 2 1 Major Facilitator Superfamily Sugar_tr PF00083.24 ETO32509.1 - 1.7e-06 27.2 3.4 1.7e-06 27.2 3.4 1.7 1 1 1 2 2 2 1 Sugar (and other) transporter Nucleoside_tran PF01733.18 ETO32509.1 - 0.00059 19.3 0.6 0.076 12.4 0.1 2.1 1 1 1 2 2 2 2 Nucleoside transporter DUF2633 PF11119.8 ETO32509.1 - 0.11 12.4 0.3 0.49 10.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2633) SpoVR PF04293.13 ETO32509.1 - 0.24 10.1 2.6 0.32 9.6 2.6 1.2 1 0 0 1 1 1 0 SpoVR like protein ABC_tran PF00005.27 ETO32510.1 - 2.6e-11 44.2 0.0 3e-11 44.0 0.0 1.0 1 0 0 1 1 1 1 ABC transporter Wzz PF02706.15 ETO32513.1 - 0.12 12.7 0.8 1.7 9.0 0.1 2.4 2 0 0 2 2 2 0 Chain length determinant protein FH2 PF02181.23 ETO32514.1 - 1.2e-29 103.6 14.1 7.9e-29 100.9 14.1 2.3 1 1 0 1 1 1 1 Formin Homology 2 Domain bZIP_1 PF00170.21 ETO32514.1 - 0.03 14.4 1.6 0.19 11.9 1.6 2.4 1 0 0 1 1 1 0 bZIP transcription factor DUF2935 PF11155.8 ETO32514.1 - 0.12 12.7 5.0 21 5.5 0.0 4.2 5 0 0 5 5 5 0 Domain of unknown function (DUF2935) DDE_Tnp_IS1595 PF12762.7 ETO32514.1 - 1 9.3 3.9 0.38 10.8 0.3 2.2 3 0 0 3 3 3 0 ISXO2-like transposase domain Cnn_1N PF07989.11 ETO32514.1 - 5.3 7.3 11.0 0.39 10.9 0.3 4.5 4 0 0 4 4 4 0 Centrosomin N-terminal motif 1 PPR PF01535.20 ETO32516.1 - 0.0031 17.6 0.2 4.7 7.7 0.1 3.8 3 0 0 3 3 3 1 PPR repeat zf-Tim10_DDP PF02953.15 ETO32516.1 - 0.037 13.7 0.5 0.12 12.0 0.5 1.8 1 0 0 1 1 1 0 Tim10/DDP family zinc finger PPR_3 PF13812.6 ETO32516.1 - 0.097 12.8 0.1 0.6 10.2 0.1 2.4 1 1 0 1 1 1 0 Pentatricopeptide repeat domain IRK PF01007.20 ETO32516.1 - 4.4 7.1 9.3 0.27 11.1 0.5 3.0 3 1 1 4 4 4 0 Inward rectifier potassium channel transmembrane domain PPR_2 PF13041.6 ETO32517.1 - 1.5e-10 41.1 0.2 8.6e-08 32.3 0.0 3.1 2 1 0 2 2 2 2 PPR repeat family PPR_3 PF13812.6 ETO32517.1 - 4.2e-05 23.5 1.3 0.00012 22.1 0.1 2.4 4 0 0 4 4 4 1 Pentatricopeptide repeat domain PPR PF01535.20 ETO32517.1 - 0.0037 17.4 0.1 0.045 14.0 0.0 2.6 2 0 0 2 2 2 1 PPR repeat PPR_1 PF12854.7 ETO32517.1 - 0.015 15.0 0.1 0.64 9.8 0.0 2.7 3 0 0 3 3 3 0 PPR repeat DUF2115 PF09888.9 ETO32517.1 - 0.058 13.9 0.5 0.94 10.0 0.1 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2115) WD40 PF00400.32 ETO32518.1 - 1.1e-09 38.7 5.8 3 8.9 0.0 6.6 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32518.1 - 2.6e-09 37.3 0.1 0.02 15.2 0.0 4.9 1 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Cytochrom_D1 PF02239.16 ETO32518.1 - 4.8e-06 25.4 0.2 0.027 13.0 0.1 2.5 2 0 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO32518.1 - 0.017 15.0 3.1 0.62 10.1 0.1 4.1 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF1963 PF09234.10 ETO32518.1 - 0.8 10.1 7.8 1.6 9.1 7.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) TRAP-gamma PF07074.12 ETO32520.1 - 0.049 13.2 1.3 0.067 12.8 1.3 1.3 1 0 0 1 1 1 0 Translocon-associated protein, gamma subunit (TRAP-gamma) WD40 PF00400.32 ETO32521.1 - 2e-51 170.8 8.5 5.8e-11 42.8 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32521.1 - 9.4e-21 73.9 2.5 3.1e-05 24.2 0.1 6.2 2 1 4 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32521.1 - 1.7e-14 53.5 0.4 0.027 13.4 0.0 6.7 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32521.1 - 6e-08 31.8 4.1 0.29 9.7 0.0 5.2 2 1 1 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32521.1 - 2.7e-05 23.7 1.3 0.052 12.9 0.5 3.0 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO32521.1 - 5.7e-05 22.9 1.9 5.8 7.0 0.0 5.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO32521.1 - 0.00035 20.6 0.4 10 6.2 0.0 4.2 3 2 1 5 5 5 1 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO32521.1 - 0.0031 16.5 0.0 1.6 7.6 0.0 3.5 4 0 0 4 4 4 1 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 ETO32521.1 - 0.0052 16.4 0.0 0.025 14.2 0.0 1.9 1 1 0 1 1 1 1 PQQ-like domain Cytochrom_D1 PF02239.16 ETO32521.1 - 0.0053 15.3 0.0 3.1 6.2 0.0 3.3 2 1 2 4 4 4 1 Cytochrome D1 heme domain Mid2 PF04478.12 ETO32521.1 - 0.01 15.7 1.8 4.3 7.1 0.1 4.3 2 2 3 5 5 5 0 Mid2 like cell wall stress sensor PALB2_WD40 PF16756.5 ETO32521.1 - 0.022 13.7 0.5 3.3 6.5 0.0 3.3 4 1 1 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Str_synth PF03088.16 ETO32521.1 - 0.028 14.5 0.3 20 5.4 0.0 3.9 5 0 0 5 5 5 0 Strictosidine synthase DUF4988 PF16378.5 ETO32521.1 - 0.078 12.6 0.1 20 4.8 0.0 3.2 1 1 1 3 3 3 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO32521.1 - 0.39 10.4 5.1 14 5.5 0.1 4.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Ras PF00071.22 ETO32522.1 - 3e-59 199.2 0.1 4.7e-59 198.6 0.1 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO32522.1 - 9.9e-33 112.9 0.1 2.6e-32 111.6 0.0 1.7 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO32522.1 - 4.1e-13 49.2 0.0 5.8e-13 48.7 0.0 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO32522.1 - 4.3e-06 26.7 0.0 0.012 15.5 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase GTP_EFTU PF00009.27 ETO32522.1 - 4.2e-05 23.2 0.1 0.00074 19.1 0.0 2.3 2 1 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO32522.1 - 0.00011 21.7 0.0 0.00021 20.8 0.0 1.5 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO32522.1 - 0.00014 21.9 0.0 0.00041 20.4 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO32522.1 - 0.13 12.8 0.2 0.18 12.3 0.2 1.7 1 1 0 1 1 1 0 ABC transporter Fibrinogen_BP PF08017.11 ETO32523.1 - 0.04 12.4 0.3 0.054 11.9 0.3 1.3 1 0 0 1 1 1 0 Fibrinogen binding protein DUF1664 PF07889.12 ETO32524.1 - 0.028 14.5 6.0 0.096 12.7 2.7 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DotA PF11388.8 ETO32524.1 - 0.049 13.8 0.2 0.091 13.0 0.2 1.4 1 0 0 1 1 1 0 Phagosome trafficking protein DotA Imm30 PF15565.6 ETO32524.1 - 0.052 13.6 4.8 0.8 9.8 0.4 3.1 1 1 1 2 2 2 0 Immunity protein 30 zf-C4H2 PF10146.9 ETO32524.1 - 0.1 12.9 6.5 0.19 12.0 6.5 1.5 1 0 0 1 1 1 0 Zinc finger-containing protein USP8_interact PF08941.10 ETO32524.1 - 0.12 12.2 3.3 1 9.1 0.2 2.0 1 1 1 2 2 2 0 USP8 interacting DUF2570 PF10828.8 ETO32524.1 - 0.49 10.2 5.6 0.42 10.5 1.6 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2570) DUF5584 PF17822.1 ETO32525.1 - 0.11 12.0 0.3 8.3 5.8 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5584) DUF745 PF05335.13 ETO32526.1 - 0.0073 16.0 11.4 0.0073 16.0 11.4 11.2 6 4 5 11 11 11 2 Protein of unknown function (DUF745) ABC2_membrane_2 PF12679.7 ETO32526.1 - 0.14 11.4 0.2 0.54 9.5 0.2 2.0 1 0 0 1 1 1 0 ABC-2 family transporter protein Mce4_CUP1 PF11887.8 ETO32526.1 - 1.4 8.3 6.8 2.6 7.4 4.4 2.9 2 0 0 2 2 2 0 Cholesterol uptake porter CUP1 of Mce4, putative WD40 PF00400.32 ETO32527.1 - 1.2e-10 41.7 11.4 0.029 15.2 0.2 7.0 7 0 0 7 7 7 3 WD domain, G-beta repeat eIF-3c_N PF05470.12 ETO32527.1 - 1.4e-06 27.0 0.0 1e-05 24.1 0.0 2.1 1 1 1 2 2 2 1 Eukaryotic translation initiation factor 3 subunit 8 N-terminus ANAPC4_WD40 PF12894.7 ETO32527.1 - 3.7e-05 23.9 0.1 0.64 10.4 0.2 4.7 4 1 1 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain PQQ_3 PF13570.6 ETO32527.1 - 0.2 12.2 0.1 6.5 7.4 0.0 3.1 3 0 0 3 3 3 0 PQQ-like domain NACHT PF05729.12 ETO32528.1 - 1e-18 67.8 0.0 4.6e-18 65.7 0.0 2.0 1 1 0 1 1 1 1 NACHT domain DUF87 PF01935.17 ETO32528.1 - 0.0011 19.1 0.9 0.042 14.0 0.0 2.8 3 0 0 3 3 3 1 Helicase HerA, central domain NB-ARC PF00931.22 ETO32528.1 - 0.0082 15.4 0.0 0.033 13.4 0.0 2.1 1 1 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO32528.1 - 0.013 15.8 0.0 0.042 14.1 0.0 1.9 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO32528.1 - 0.045 14.1 0.0 0.24 11.8 0.0 2.2 2 0 0 2 2 2 0 AAA ATPase domain RR_TM4-6 PF06459.12 ETO32529.1 - 1.5 8.6 27.9 0.081 12.7 19.2 2.2 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 Nop14 PF04147.12 ETO32529.1 - 1.5 7.0 39.1 0.027 12.7 31.7 1.7 2 0 0 2 2 2 0 Nop14-like family Spt5_N PF11942.8 ETO32529.1 - 1.8 9.6 40.3 0.082 13.9 29.6 3.1 3 0 0 3 3 3 0 Spt5 transcription elongation factor, acidic N-terminal TAF4 PF05236.14 ETO32529.1 - 3.4 7.3 19.6 0.045 13.5 9.3 2.1 2 0 0 2 2 2 0 Transcription initiation factor TFIID component TAF4 family CAP_GLY PF01302.25 ETO32530.1 - 0.006 16.6 0.1 0.011 15.7 0.0 1.5 2 0 0 2 2 2 1 CAP-Gly domain COX8 PF02285.15 ETO32532.1 - 0.19 11.7 0.1 0.46 10.4 0.1 1.6 1 0 0 1 1 1 0 Cytochrome oxidase c subunit VIII TMEM18 PF14770.6 ETO32532.1 - 0.5 10.4 4.3 0.22 11.5 1.7 1.7 2 0 0 2 2 2 0 Transmembrane protein 18 TMP PF05017.14 ETO32533.1 - 0.61 10.9 2.3 67 4.9 0.1 3.9 3 0 0 3 3 3 0 TMP repeat DUF4838 PF16126.5 ETO32534.1 - 0.049 13.0 2.8 0.083 12.3 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4838) Presenilin PF01080.17 ETO32536.1 - 0.0028 16.5 0.0 0.0028 16.5 0.0 3.1 2 1 1 3 3 3 2 Presenilin Innate_immun PF12782.7 ETO32536.1 - 0.23 10.9 6.6 0.59 9.6 6.6 1.6 1 0 0 1 1 1 0 Invertebrate innate immunity transcript family F-box PF00646.33 ETO32537.1 - 9.3e-05 22.2 0.2 0.00018 21.3 0.2 1.5 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO32537.1 - 0.00011 22.0 0.1 0.00019 21.3 0.1 1.3 1 0 0 1 1 1 1 F-box-like F-box_4 PF15966.5 ETO32537.1 - 0.0031 17.4 0.1 0.005 16.7 0.1 1.4 1 0 0 1 1 1 1 F-box TPR_12 PF13424.6 ETO32538.1 - 1.1e-40 137.8 8.9 3.1e-18 65.9 0.4 3.4 1 1 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32538.1 - 1.7e-35 119.9 0.2 1e-08 34.7 0.0 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32538.1 - 3.4e-29 98.7 6.2 8.7e-07 28.5 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32538.1 - 7.1e-29 98.4 26.8 5.3e-09 35.5 1.9 5.4 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32538.1 - 4.3e-24 82.6 22.1 5.3e-08 32.4 1.6 5.3 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32538.1 - 1.2e-18 65.6 27.0 3e-05 23.9 1.2 5.2 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO32538.1 - 1.2e-09 38.2 11.0 0.018 15.6 0.2 5.2 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO32538.1 - 5.7e-09 36.1 0.1 0.23 12.4 0.0 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO32538.1 - 7.5e-08 32.2 7.5 0.058 13.8 0.0 5.1 5 1 0 5 5 4 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO32538.1 - 1.1e-07 32.4 0.0 0.00019 22.0 0.1 4.0 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO32538.1 - 1.8e-06 27.8 15.5 0.00031 20.6 1.8 3.8 4 0 0 4 4 3 2 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO32538.1 - 6.7e-06 25.5 1.0 0.23 10.9 0.0 4.1 4 0 0 4 4 4 2 SHNi-TPR DUF2225 PF09986.9 ETO32538.1 - 0.00013 21.7 14.0 0.00066 19.5 2.7 2.4 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETO32538.1 - 0.00014 21.4 26.9 0.002 17.8 1.2 5.9 7 1 1 8 8 8 2 TPR repeat SPO22 PF08631.10 ETO32538.1 - 0.00061 19.4 8.7 0.21 11.0 0.2 3.3 3 1 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like TPR_MalT PF17874.1 ETO32538.1 - 0.0011 18.4 0.0 0.0016 17.9 0.0 1.2 1 0 0 1 1 1 1 MalT-like TPR region PPR PF01535.20 ETO32538.1 - 0.0017 18.5 2.8 39 4.8 0.0 5.1 5 0 0 5 5 5 0 PPR repeat ANAPC3 PF12895.7 ETO32538.1 - 0.017 15.3 15.1 0.059 13.6 1.7 4.3 2 1 2 5 5 5 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO32538.1 - 0.024 14.7 14.4 0.13 12.3 0.2 4.9 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO32538.1 - 0.026 15.0 0.3 2.7 8.6 0.0 2.7 3 0 0 3 3 2 0 Tetratricopeptide repeat Glyoxalase PF00903.25 ETO32538.1 - 0.25 11.5 1.2 2.8 8.1 0.1 2.5 2 1 1 3 3 2 0 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily HTH_Bact PF18768.1 ETO32538.1 - 0.5 10.0 6.0 27 4.4 0.0 4.5 4 1 0 4 4 4 0 Helix-turn-helix bacterial domain Inhibitor_I29 PF08246.12 ETO32538.1 - 0.74 10.3 10.0 0.8 10.2 1.4 3.6 3 1 0 3 3 3 0 Cathepsin propeptide inhibitor domain (I29) Fis1_TPR_C PF14853.6 ETO32538.1 - 0.75 9.9 16.6 0.67 10.1 1.1 4.0 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat TraN PF06986.11 ETO32539.1 - 0.028 14.1 0.2 0.038 13.7 0.2 1.1 1 0 0 1 1 1 0 Type-1V conjugative transfer system mating pair stabilisation SYCE1 PF15233.6 ETO32539.1 - 0.072 13.1 0.3 0.072 13.1 0.3 1.8 2 0 0 2 2 2 0 Synaptonemal complex central element protein 1 Pox_Ag35 PF03286.14 ETO32539.1 - 0.2 11.5 7.1 0.28 10.9 7.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Mito_fiss_reg PF05308.11 ETO32539.1 - 0.35 10.9 7.0 0.53 10.3 7.0 1.3 1 0 0 1 1 1 0 Mitochondrial fission regulator HR1 PF02185.16 ETO32539.1 - 0.48 10.6 6.2 7.7 6.7 1.5 2.2 2 0 0 2 2 2 0 Hr1 repeat FmiP_Thoc5 PF09766.9 ETO32540.1 - 0.00019 20.8 4.3 0.00024 20.5 4.3 1.2 1 0 0 1 1 1 1 Fms-interacting protein/Thoc5 DUF2254 PF10011.9 ETO32540.1 - 0.04 12.7 0.9 0.064 12.1 0.9 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2254) CobT PF06213.12 ETO32540.1 - 0.059 12.7 8.3 0.08 12.3 8.3 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT ORC_WH_C PF18137.1 ETO32540.1 - 0.38 10.8 6.8 0.65 10.1 6.8 1.3 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Trypan_PARP PF05887.11 ETO32540.1 - 0.38 10.7 7.8 0.55 10.2 7.8 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) MIF4G_like_2 PF09090.11 ETO32540.1 - 0.89 9.0 11.5 1.5 8.3 11.5 1.5 1 1 0 1 1 1 0 MIF4G like NOA36 PF06524.12 ETO32540.1 - 1.7 7.9 9.4 2.3 7.4 9.4 1.2 1 0 0 1 1 1 0 NOA36 protein VSP PF03302.13 ETO32541.1 - 0.024 13.5 0.3 0.032 13.1 0.3 1.1 1 0 0 1 1 1 0 Giardia variant-specific surface protein Prominin PF05478.11 ETO32541.1 - 0.089 10.7 0.0 0.11 10.5 0.0 1.0 1 0 0 1 1 1 0 Prominin WD40 PF00400.32 ETO32542.1 - 7.2e-122 393.8 56.5 9.4e-12 45.3 0.1 16.0 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32542.1 - 2.5e-30 104.6 20.7 0.034 14.4 0.0 14.0 3 2 11 15 15 15 10 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32542.1 - 1.3e-16 60.8 15.4 1.4e-05 24.6 0.5 7.7 3 2 3 7 7 7 5 WD40-like domain Ge1_WD40 PF16529.5 ETO32542.1 - 3.2e-16 59.2 17.2 0.13 11.2 0.0 11.0 2 1 8 11 11 11 7 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32542.1 - 6.6e-12 44.9 26.2 0.079 11.6 0.2 11.3 1 1 6 10 10 10 5 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO32542.1 - 4e-06 26.3 1.3 9.9e-06 25.1 1.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DPPIV_N PF00930.21 ETO32542.1 - 2.3e-05 23.3 1.1 0.21 10.3 0.0 5.5 3 3 3 6 6 6 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Pentapeptide_4 PF13599.6 ETO32542.1 - 0.00083 19.5 0.2 0.003 17.7 0.2 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Str_synth PF03088.16 ETO32542.1 - 0.00085 19.4 0.3 4.4 7.5 0.0 5.7 6 2 2 8 8 8 1 Strictosidine synthase Pentapeptide_3 PF13576.6 ETO32542.1 - 0.0068 16.5 0.1 0.016 15.3 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Tagatose_6_P_K PF08013.11 ETO32542.1 - 0.17 10.5 0.9 9.7 4.7 0.0 2.8 3 0 0 3 3 3 0 Tagatose 6 phosphate kinase PKD PF00801.20 ETO32542.1 - 0.22 11.4 1.0 1.1e+02 2.7 0.0 4.7 6 0 0 6 6 6 0 PKD domain PD40 PF07676.12 ETO32542.1 - 1.2 9.1 18.1 69 3.5 0.2 7.5 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat DUF2434 PF10361.9 ETO32546.1 - 0.15 11.0 0.5 0.16 10.9 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2434) WD40 PF00400.32 ETO32547.1 - 1.3e-27 95.5 11.9 1.1e-06 29.3 0.3 5.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32547.1 - 4e-06 27.0 0.1 0.044 14.1 0.0 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32547.1 - 8e-06 24.8 0.6 0.0027 16.4 0.2 3.2 1 1 2 3 3 3 2 Nucleoporin Nup120/160 fn3_PAP PF17808.1 ETO32547.1 - 0.1 12.7 0.5 0.71 10.0 0.2 2.2 2 0 0 2 2 2 0 Fn3-like domain from Purple Acid Phosphatase SWI-SNF_Ssr4 PF08549.10 ETO32548.1 - 0.14 10.8 19.9 0.16 10.6 19.9 1.0 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) LAP1C PF05609.12 ETO32548.1 - 0.38 9.8 19.0 0.44 9.6 19.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Presenilin PF01080.17 ETO32548.1 - 0.74 8.5 16.9 1.1 7.9 16.9 1.4 1 0 0 1 1 1 0 Presenilin GREB1 PF15782.5 ETO32548.1 - 2.1 5.3 15.5 2.2 5.3 15.5 1.1 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Neur_chan_memb PF02932.16 ETO32548.1 - 3.4 7.7 9.2 5.1 7.1 9.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Raftlin PF15250.6 ETO32548.1 - 5.4 5.7 14.6 6.5 5.4 14.6 1.1 1 0 0 1 1 1 0 Raftlin TPR_17 PF13431.6 ETO32549.1 - 7.3e-08 32.3 2.2 0.041 14.3 0.2 3.4 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32549.1 - 3.4e-05 23.4 0.9 0.024 14.3 0.0 3.6 4 0 0 4 4 4 1 TPR repeat TPR_14 PF13428.6 ETO32549.1 - 0.00015 22.3 0.4 0.11 13.3 0.1 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32549.1 - 0.00037 20.2 10.1 1 9.3 0.1 5.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32549.1 - 0.0012 18.8 7.6 1.6 9.0 0.5 4.9 3 2 0 3 3 3 2 Tetratricopeptide repeat FAT PF02259.23 ETO32549.1 - 0.042 13.1 0.2 0.048 12.9 0.2 1.2 1 0 0 1 1 1 0 FAT domain TPR_19 PF14559.6 ETO32549.1 - 0.09 13.3 0.2 12 6.5 0.1 2.4 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32549.1 - 0.25 11.6 1.9 30 5.2 0.2 3.5 3 1 0 3 3 3 0 Tetratricopeptide repeat adh_short PF00106.25 ETO32550.1 - 3.6e-41 140.8 0.3 4.1e-41 140.6 0.3 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO32550.1 - 6.6e-31 107.7 0.0 7.4e-31 107.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO32550.1 - 5.2e-06 26.5 0.0 8.1e-06 25.9 0.0 1.5 1 1 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO32550.1 - 0.066 12.7 0.0 0.16 11.4 0.0 1.8 1 1 1 2 2 2 0 NAD dependent epimerase/dehydratase family DUF3221 PF11518.8 ETO32551.1 - 2.6 8.5 7.3 15 6.1 4.3 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3221) Choline_kinase PF01633.20 ETO32552.1 - 0.00029 20.5 0.1 0.00055 19.6 0.1 1.4 1 0 0 1 1 1 1 Choline/ethanolamine kinase Choline_kinase PF01633.20 ETO32553.1 - 9.2e-26 90.7 6.9 9.2e-26 90.7 6.9 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase APH PF01636.23 ETO32553.1 - 8.8e-05 22.5 0.5 0.00012 22.1 0.5 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family Pkinase PF00069.25 ETO32553.1 - 0.01 15.2 0.5 0.017 14.5 0.5 1.4 1 0 0 1 1 1 0 Protein kinase domain TPR_14 PF13428.6 ETO32555.1 - 0.00019 22.0 1.5 4 8.5 0.0 4.5 1 1 4 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32555.1 - 0.00037 20.1 3.1 1.3 8.7 0.0 3.9 4 0 0 4 4 4 1 TPR repeat TPR_12 PF13424.6 ETO32555.1 - 0.00069 19.9 9.2 0.24 11.7 0.1 4.5 4 2 1 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32555.1 - 0.0013 18.8 4.6 0.81 10.1 0.0 3.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_19 PF14559.6 ETO32555.1 - 0.0016 18.9 5.3 2.3 8.8 0.0 3.9 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32555.1 - 0.004 16.9 9.3 0.59 10.0 0.3 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32555.1 - 0.0049 16.9 16.9 1.7 9.0 0.1 5.4 6 0 0 6 6 6 3 Tetratricopeptide repeat CobT PF06213.12 ETO32555.1 - 0.018 14.5 18.4 0.035 13.5 18.4 1.6 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT TPR_16 PF13432.6 ETO32555.1 - 0.019 15.6 0.2 22 5.8 0.0 3.3 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32555.1 - 0.022 14.7 0.7 9.7 6.5 0.0 3.8 3 0 0 3 3 3 0 Tetratricopeptide repeat FERM_N_2 PF18038.1 ETO32555.1 - 0.091 13.6 0.8 28 5.6 0.2 2.8 2 0 0 2 2 2 0 FERM N-terminal domain TPR_9 PF13371.6 ETO32555.1 - 0.39 10.9 1.8 5 7.3 0.0 3.1 4 0 0 4 4 3 0 Tetratricopeptide repeat RRN3 PF05327.11 ETO32555.1 - 0.69 8.4 16.0 1.2 7.6 16.0 1.5 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 RR_TM4-6 PF06459.12 ETO32555.1 - 0.85 9.4 17.1 0.27 11.0 10.4 2.3 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 ANAPC3 PF12895.7 ETO32555.1 - 0.87 9.9 9.3 57 4.0 9.3 3.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 Zip PF02535.22 ETO32555.1 - 1.1 8.4 12.3 1.2 8.3 6.8 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter NOA36 PF06524.12 ETO32555.1 - 1.4 8.1 28.8 2.8 7.2 28.8 1.5 1 0 0 1 1 1 0 NOA36 protein Nop14 PF04147.12 ETO32555.1 - 1.5 6.9 35.3 0.17 10.0 30.3 1.8 2 0 0 2 2 2 0 Nop14-like family Astro_capsid_p PF12226.8 ETO32555.1 - 1.8 7.6 29.5 0.04 13.1 22.3 1.8 1 1 1 2 2 2 0 Turkey astrovirus capsid protein CPSF100_C PF13299.6 ETO32555.1 - 2.2 8.4 9.2 0.63 10.2 4.9 2.3 3 0 0 3 3 2 0 Cleavage and polyadenylation factor 2 C-terminal DUF1980 PF09323.10 ETO32555.1 - 5.5 6.9 9.3 1.6 8.6 0.3 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF1980) DUF913 PF06025.12 ETO32555.1 - 6.7 5.6 10.1 1.3 7.9 5.7 1.8 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) COPI_C PF06957.11 ETO32555.1 - 8.9 4.9 17.2 20 3.8 17.2 1.5 1 0 0 1 1 1 0 Coatomer (COPI) alpha subunit C-terminus cNMP_binding PF00027.29 ETO32557.1 - 1.1e-29 102.3 0.5 1e-08 35.1 0.0 4.3 4 0 0 4 4 4 4 Cyclic nucleotide-binding domain FAM176 PF14851.6 ETO32557.1 - 0.2 11.3 11.7 0.24 11.0 1.0 3.4 3 1 0 3 3 3 0 FAM176 family CPSF100_C PF13299.6 ETO32557.1 - 0.47 10.6 5.0 1.7 8.8 0.3 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RNase_H2_suC PF08615.11 ETO32557.1 - 0.58 10.3 3.5 0.67 10.1 0.0 2.3 1 1 1 2 2 2 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) PBP1_TM PF14812.6 ETO32557.1 - 5 7.6 10.1 0.63 10.5 0.6 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal RNB PF00773.19 ETO32558.1 - 2.3e-20 73.2 0.5 3e-20 72.8 0.5 1.1 1 0 0 1 1 1 1 RNB domain ECSIT_C PF14784.6 ETO32559.1 - 0.024 15.0 1.6 0.03 14.6 0.4 1.8 1 1 1 2 2 2 0 C-terminal domain of the ECSIT protein RGS12_us1 PF16613.5 ETO32559.1 - 0.066 13.5 0.6 0.086 13.2 0.6 1.3 1 0 0 1 1 1 0 Unstructured region of RGS12 Cation_ATPase PF13246.6 ETO32559.1 - 1 9.5 5.9 4.4 7.5 4.3 2.5 2 1 0 2 2 2 0 Cation transport ATPase (P-type) CNOT1_HEAT_N PF16419.5 ETO32560.1 - 0.033 13.9 0.5 0.035 13.8 0.5 1.1 1 0 0 1 1 1 0 CCR4-NOT transcription complex subunit 1 HEAT repeat RasGEF_N PF00618.20 ETO32560.1 - 0.23 11.7 1.8 1.6 9.0 0.3 2.4 1 1 2 3 3 3 0 RasGEF N-terminal motif ASCH PF04266.14 ETO32561.1 - 1.7e-05 25.3 0.9 7.8e-05 23.2 0.0 2.2 2 1 0 2 2 2 1 ASCH domain OHCU_decarbox PF09349.10 ETO32561.1 - 0.072 13.6 0.0 0.19 12.2 0.0 1.7 1 0 0 1 1 1 0 OHCU decarboxylase SpoVIF PF14069.6 ETO32562.1 - 0.098 12.4 0.3 0.14 11.9 0.3 1.2 1 0 0 1 1 1 0 Stage VI sporulation protein F AIRC PF00731.20 ETO32562.1 - 0.15 11.6 0.0 0.2 11.2 0.0 1.1 1 0 0 1 1 1 0 AIR carboxylase DUF2207 PF09972.9 ETO32562.1 - 0.32 9.7 2.2 0.36 9.5 2.2 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) 2TM PF13239.6 ETO32562.1 - 3.5 8.0 6.5 0.58 10.5 2.5 1.8 2 0 0 2 2 2 0 2TM domain DRMBL PF07522.14 ETO32563.1 - 3.2e-15 56.3 0.4 3.2e-15 56.3 0.4 2.2 2 0 0 2 2 2 1 DNA repair metallo-beta-lactamase YL1 PF05764.13 ETO32563.1 - 0.0039 17.3 3.8 0.0039 17.3 3.8 2.3 2 0 0 2 2 2 1 YL1 nuclear protein RMMBL PF07521.12 ETO32563.1 - 0.025 14.5 0.2 0.085 12.8 0.0 2.0 2 0 0 2 2 2 0 Zn-dependent metallo-hydrolase RNA specificity domain CENP-B_dimeris PF09026.10 ETO32563.1 - 0.11 12.9 16.5 0.27 11.7 16.5 1.6 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BUD22 PF09073.10 ETO32563.1 - 0.97 8.7 16.2 0.036 13.4 3.4 2.2 2 0 0 2 2 2 0 BUD22 CvfB_WH PF17783.1 ETO32566.1 - 2.7e-11 43.1 0.0 6.6e-11 41.9 0.0 1.7 1 0 0 1 1 1 1 CvfB-like winged helix domain Menin PF05053.13 ETO32566.1 - 0.084 11.2 6.5 0.11 10.8 6.5 1.2 1 0 0 1 1 1 0 Menin FlaG PF03646.15 ETO32566.1 - 1.7 8.9 11.0 1.3 9.3 0.0 3.0 2 0 0 2 2 2 0 FlaG protein Methyltransf_12 PF08242.12 ETO32566.1 - 2.8 8.8 6.1 0.91 10.3 1.8 2.3 2 0 0 2 2 2 0 Methyltransferase domain Secretin_N_2 PF07655.13 ETO32566.1 - 8.1 7.1 13.1 0.54 10.8 7.5 1.9 2 0 0 2 2 2 0 Secretin N-terminal domain Presenilin PF01080.17 ETO32566.1 - 9.1 4.9 5.8 14 4.3 5.8 1.3 1 0 0 1 1 1 0 Presenilin MT-A70 PF05063.14 ETO32567.1 - 3.2e-07 30.4 2.8 1.2e-05 25.4 2.8 2.1 1 1 0 1 1 1 1 MT-A70 ATP1G1_PLM_MAT8 PF02038.16 ETO32567.1 - 0.23 10.9 1.4 0.5 9.8 1.4 1.6 1 0 0 1 1 1 0 ATP1G1/PLM/MAT8 family Peptidase_M99_m PF17130.4 ETO32569.1 - 0.13 12.3 0.4 0.4 10.6 0.2 1.9 2 0 0 2 2 2 0 beta-barrel domain of carboxypeptidase M99 TLD PF07534.16 ETO32571.1 - 2.1e-06 28.0 0.1 6.6e-05 23.2 0.1 2.5 2 0 0 2 2 2 2 TLD Acyl_CoA_thio PF02551.15 ETO32572.1 - 0.01 15.7 2.0 0.015 15.2 2.0 1.4 1 1 0 1 1 1 0 Acyl-CoA thioesterase DUF5409 PF17421.2 ETO32572.1 - 0.14 12.9 9.5 0.068 13.9 5.3 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5409) RNase_H2-Ydr279 PF09468.10 ETO32573.1 - 1.3e-14 54.7 0.8 2.2e-14 54.0 0.6 1.5 1 1 0 1 1 1 1 Ydr279p protein family (RNase H2 complex component) wHTH domain Ydr279_N PF17745.1 ETO32573.1 - 2.5e-09 37.2 0.0 5.1e-09 36.3 0.0 1.6 1 0 0 1 1 1 1 Ydr279p protein triple barrel domain SurA_N_2 PF13623.6 ETO32573.1 - 0.056 13.3 0.2 0.097 12.5 0.2 1.4 1 0 0 1 1 1 0 SurA N-terminal domain CAMSAP_CKK PF08683.11 ETO32573.1 - 0.1 12.8 0.0 0.28 11.3 0.0 1.8 1 0 0 1 1 1 0 Microtubule-binding calmodulin-regulated spectrin-associated DUF211 PF02680.14 ETO32575.1 - 1.9 8.7 9.6 0.38 10.9 0.4 2.9 2 1 1 3 3 3 0 Uncharacterized ArCR, COG1888 FtsJ PF01728.19 ETO32576.1 - 2.4e-13 50.6 0.2 3.3e-13 50.1 0.2 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase DUF5010 PF16402.5 ETO32576.1 - 0.0015 17.4 0.7 0.0021 16.9 0.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5010) Zf_RING PF16744.5 ETO32576.1 - 0.11 12.7 0.1 0.22 11.7 0.1 1.5 1 0 0 1 1 1 0 KIAA1045 RING finger FRB_dom PF08771.11 ETO32576.1 - 3.6 8.1 5.9 1.4 9.4 0.8 2.5 2 1 1 3 3 3 0 FKBP12-rapamycin binding domain tRNA_anti-codon PF01336.25 ETO32577.1 - 1.7e-07 31.1 0.0 3.2e-07 30.2 0.0 1.4 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain YccF PF03733.13 ETO32577.1 - 0.00012 22.7 10.3 0.00022 21.9 10.3 1.5 1 0 0 1 1 1 1 Inner membrane component domain GABP-alpha PF11620.8 ETO32578.1 - 0.063 13.5 2.3 0.32 11.2 0.3 2.8 2 0 0 2 2 2 0 GA-binding protein alpha chain CitG PF01874.16 ETO32579.1 - 0.22 11.1 0.8 3.9 7.0 0.1 2.4 2 0 0 2 2 2 0 ATP:dephospho-CoA triphosphoribosyl transferase CS PF04969.16 ETO32580.1 - 2.1e-15 57.5 2.3 4.2e-15 56.5 2.3 1.5 1 0 0 1 1 1 1 CS domain zf-RanBP PF00641.18 ETO32581.1 - 0.00036 19.8 2.1 0.00036 19.8 2.1 2.2 2 0 0 2 2 2 1 Zn-finger in Ran binding protein and others DUF2616 PF11077.8 ETO32581.1 - 0.017 14.8 2.3 0.036 13.8 1.9 1.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2616) Vps36-NZF-N PF16988.5 ETO32581.1 - 0.017 14.5 1.8 0.15 11.5 1.2 2.5 2 0 0 2 2 2 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain Vpu PF00558.19 ETO32581.1 - 0.77 9.6 2.6 1.4 8.7 2.6 1.4 1 0 0 1 1 1 0 Vpu protein Cas_CXXC_CXXC PF09706.10 ETO32581.1 - 1.6 9.0 6.4 2 8.7 0.0 3.1 3 1 1 4 4 4 0 CRISPR-associated protein (Cas_CXXC_CXXC) DZR PF12773.7 ETO32581.1 - 1.7 8.7 5.8 15 5.7 6.1 2.1 1 1 1 2 2 2 0 Double zinc ribbon Pkinase PF00069.25 ETO32582.1 - 6.9e-05 22.3 0.0 8.5e-05 22.0 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ETO32583.1 - 4.7e-07 30.4 1.8 0.033 15.1 0.2 2.9 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO32583.1 - 0.00032 19.5 0.1 0.17 10.5 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32583.1 - 0.022 15.0 0.0 2.9 8.3 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain RicinB_lectin_2 PF14200.6 ETO32583.1 - 0.039 14.7 0.1 0.26 12.0 0.1 1.9 1 1 0 1 1 1 0 Ricin-type beta-trefoil lectin domain-like Kelch_1 PF01344.25 ETO32584.1 - 2.1e-09 36.8 0.3 2.9e-07 29.9 0.5 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO32584.1 - 1.3e-06 28.5 0.8 0.00037 20.7 0.1 2.5 1 1 1 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO32584.1 - 2.3e-06 27.5 0.1 0.00014 21.8 0.0 2.4 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO32584.1 - 0.00053 20.2 0.0 0.0037 17.5 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO32584.1 - 0.00074 19.4 0.3 0.091 12.8 0.3 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO32584.1 - 0.0089 16.0 2.8 0.061 13.3 0.9 2.9 3 0 0 3 3 3 1 Kelch motif DUF5117 PF17148.4 ETO32584.1 - 0.038 13.9 0.1 0.064 13.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5117) DUF5342 PF17277.2 ETO32584.1 - 0.045 14.1 0.2 0.045 14.1 0.2 2.1 2 0 0 2 2 2 0 Family of unknown function (DUF5342) WD40 PF00400.32 ETO32585.1 - 1.6e-30 104.6 0.5 1e-09 38.8 0.1 4.8 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32585.1 - 2.9e-09 37.1 0.4 0.0012 19.1 0.1 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32585.1 - 1.8e-06 27.2 0.2 0.06 12.3 0.0 3.5 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO32585.1 - 1.9e-05 24.7 0.9 0.0011 18.9 0.1 2.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO32585.1 - 4.9e-05 23.1 0.1 0.64 10.0 0.0 4.1 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO32585.1 - 5.9e-05 22.5 1.5 0.004 16.5 0.1 2.1 1 1 1 2 2 2 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO32585.1 - 9.9e-05 21.6 1.9 0.00014 21.1 1.9 1.3 1 0 0 1 1 1 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO32585.1 - 0.0008 18.0 0.2 0.0075 14.8 0.1 2.1 1 1 1 2 2 2 2 Cytochrome D1 heme domain SGL PF08450.12 ETO32585.1 - 0.0017 18.0 0.1 0.0034 17.0 0.1 1.4 1 1 0 1 1 1 1 SMP-30/Gluconolactonase/LRE-like region DUF2711 PF10924.8 ETO32585.1 - 0.0034 17.0 0.1 0.0059 16.2 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF2711) B_lectin PF01453.24 ETO32585.1 - 0.026 15.1 3.1 1 9.9 0.1 2.9 1 1 3 4 4 4 0 D-mannose binding lectin ArlS_N PF18719.1 ETO32585.1 - 0.058 13.6 4.7 0.13 12.5 2.0 2.8 1 1 2 3 3 3 0 ArlS sensor domain Flagellin_C PF00700.21 ETO32586.1 - 0.048 14.0 0.7 0.082 13.3 0.7 1.5 1 1 0 1 1 1 0 Bacterial flagellin C-terminal helical region Spc7 PF08317.11 ETO32586.1 - 0.05 12.5 14.6 0.056 12.3 14.6 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein Fez1 PF06818.15 ETO32586.1 - 0.054 13.9 12.6 0.064 13.7 12.6 1.1 1 0 0 1 1 1 0 Fez1 SLD3 PF08639.10 ETO32586.1 - 0.099 11.4 9.4 0.11 11.2 9.4 1.0 1 0 0 1 1 1 0 DNA replication regulator SLD3 DUF1818 PF08848.11 ETO32586.1 - 0.13 12.4 2.6 0.15 12.2 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1818) Exonuc_VII_L PF02601.15 ETO32586.1 - 0.25 10.9 6.4 0.29 10.7 6.4 1.0 1 0 0 1 1 1 0 Exonuclease VII, large subunit MPS2 PF17060.5 ETO32586.1 - 0.26 10.5 7.5 0.28 10.4 7.5 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 IpaC_SipC PF09599.10 ETO32586.1 - 0.37 10.3 7.3 0.43 10.0 7.3 1.0 1 0 0 1 1 1 0 Salmonella-Shigella invasin protein C (IpaC_SipC) Macoilin PF09726.9 ETO32586.1 - 1.1 7.7 13.5 1.2 7.6 13.5 1.0 1 0 0 1 1 1 0 Macoilin family FOXP-CC PF16159.5 ETO32586.1 - 1.3 9.7 7.3 0.46 11.2 2.7 2.1 2 0 0 2 2 2 0 FOXP coiled-coil domain PEARLI-4 PF05278.12 ETO32586.1 - 3 7.3 15.7 4.4 6.8 15.7 1.4 1 1 0 1 1 1 0 Arabidopsis phospholipase-like protein (PEARLI 4) V_ATPase_I PF01496.19 ETO32586.1 - 3.4 5.5 7.7 3.8 5.3 7.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Borrelia_P83 PF05262.11 ETO32586.1 - 3.7 5.9 14.5 4.5 5.6 14.5 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein FliD_N PF02465.18 ETO32586.1 - 9.2 7.0 8.7 36 5.2 8.6 1.8 1 1 0 1 1 1 0 Flagellar hook-associated protein 2 N-terminus ABC_tran PF00005.27 ETO32587.1 - 4.6e-08 33.7 0.0 5.6e-08 33.4 0.0 1.0 1 0 0 1 1 1 1 ABC transporter RraB PF06877.11 ETO32588.1 - 0.076 13.7 0.6 0.091 13.5 0.6 1.1 1 0 0 1 1 1 0 Regulator of ribonuclease activity B WD40 PF00400.32 ETO32589.1 - 1.1e-15 57.7 13.8 3.4e-07 30.8 0.6 4.5 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32589.1 - 4.7e-05 23.6 1.5 1.2 9.5 0.0 3.3 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32589.1 - 0.0066 15.1 3.3 0.81 8.3 0.1 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Secretin_N_2 PF07655.13 ETO32590.1 - 3.3 8.3 10.0 5.5 7.6 10.0 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain DUF3196 PF11428.8 ETO32591.1 - 0.077 12.5 0.1 0.097 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3196) RRM_1 PF00076.22 ETO32592.1 - 1.9e-16 59.7 0.1 1e-14 54.1 0.0 3.0 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DIL PF01843.19 ETO32593.1 - 1e-10 41.8 2.8 1.4e-10 41.4 0.4 2.4 2 0 0 2 2 2 1 DIL domain WD40 PF00400.32 ETO32594.1 - 9.9e-56 184.4 21.1 1.2e-09 38.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32594.1 - 1.4e-16 60.5 2.0 0.027 14.8 0.1 6.0 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32594.1 - 1.2e-09 38.0 2.6 0.0021 17.4 0.1 3.3 2 1 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO32594.1 - 2e-09 36.9 0.4 0.45 9.4 0.0 5.3 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32594.1 - 3.7e-06 25.9 1.1 0.11 11.1 0.0 3.6 2 2 1 3 3 3 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO32594.1 - 9.2e-05 22.3 2.7 16 5.6 0.0 5.9 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO32594.1 - 0.00026 19.6 0.2 0.04 12.5 0.1 2.5 2 1 0 2 2 2 1 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO32594.1 - 0.00068 18.5 0.1 0.068 11.9 0.0 3.6 2 2 1 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5570 PF17731.1 ETO32594.1 - 0.001 19.2 0.3 4.3 7.4 0.0 3.9 2 2 2 4 4 4 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO32594.1 - 0.0015 18.2 0.0 0.0072 15.9 0.0 2.1 1 1 1 2 2 2 1 PQQ-like domain Nucleoporin_N PF08801.11 ETO32594.1 - 0.0053 15.6 6.2 0.26 10.0 0.1 3.5 1 1 1 2 2 2 1 Nup133 N terminal like PQQ PF01011.21 ETO32594.1 - 0.013 15.4 0.1 8.5 6.5 0.0 4.1 5 0 0 5 5 5 0 PQQ enzyme repeat Frtz PF11768.8 ETO32594.1 - 0.021 13.2 0.0 1.9 6.7 0.0 2.3 1 1 1 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 ETO32594.1 - 0.03 13.4 1.8 1.9 7.5 0.2 2.8 1 1 0 2 2 2 0 Coatomer WD associated region HPS6 PF15702.5 ETO32594.1 - 0.039 11.9 0.0 7.9 4.3 0.0 3.2 1 1 3 4 4 4 0 Hermansky-Pudlak syndrome 6 protein Ret2_MD PF18528.1 ETO32594.1 - 0.079 13.4 0.2 6.2 7.3 0.0 3.2 3 1 0 3 3 3 0 RNA editing 3' terminal uridylyl transferase 2 middle domain DUF371 PF04027.13 ETO32594.1 - 2.3 8.2 4.3 13 5.8 0.1 3.7 2 2 0 3 3 3 0 Domain of unknown function (DUF371) Proteasome_A_N PF10584.9 ETO32594.1 - 6.4 6.6 7.6 61 3.4 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WWE PF02825.20 ETO32597.1 - 3.8e-13 49.8 4.8 1.3e-06 28.9 0.3 2.8 3 0 0 3 3 3 2 WWE domain zf-C3HC4_3 PF13920.6 ETO32597.1 - 2.6e-07 30.4 13.7 3.6e-06 26.7 9.1 2.3 2 0 0 2 2 2 2 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO32597.1 - 5.4e-07 29.5 7.3 1.3e-06 28.3 7.3 1.8 1 0 0 1 1 1 1 RING-type zinc-finger zf-C3HC4 PF00097.25 ETO32597.1 - 2.1e-05 24.3 12.5 0.00011 22.0 12.5 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO32597.1 - 0.00013 21.7 9.4 0.00013 21.7 9.4 2.1 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_4 PF15227.6 ETO32597.1 - 0.00039 20.5 15.4 0.00065 19.8 9.3 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_2 PF13639.6 ETO32597.1 - 0.00099 19.4 16.0 0.01 16.2 16.0 2.3 1 1 0 1 1 1 1 Ring finger domain Prok-RING_4 PF14447.6 ETO32597.1 - 0.0036 17.1 14.1 0.087 12.7 8.7 2.6 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf-RING_5 PF14634.6 ETO32597.1 - 0.0039 17.1 12.8 0.028 14.4 12.5 2.5 1 1 1 2 2 2 1 zinc-RING finger domain zf-RING_11 PF17123.5 ETO32597.1 - 0.0045 16.7 9.6 0.028 14.2 10.1 2.1 1 1 1 2 2 2 1 RING-like zinc finger zf-XS PF03470.14 ETO32597.1 - 3.8 7.8 7.6 11 6.4 1.3 2.8 2 0 0 2 2 2 0 XS zinc finger domain zf-C3HC4_3 PF13920.6 ETO32598.1 - 2.4e-07 30.5 8.9 4.4e-07 29.7 8.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO32598.1 - 0.00098 19.4 9.1 0.0019 18.5 9.1 1.5 1 0 0 1 1 1 1 Ring finger domain zf-C3HC4 PF00097.25 ETO32598.1 - 0.0035 17.2 9.4 0.009 15.9 9.4 1.7 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) BUD22 PF09073.10 ETO32598.1 - 0.005 16.2 30.5 0.0068 15.8 30.5 1.2 1 0 0 1 1 1 1 BUD22 DUF2457 PF10446.9 ETO32598.1 - 0.012 14.8 39.1 0.016 14.4 39.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) zf-RING_5 PF14634.6 ETO32598.1 - 0.064 13.2 12.2 0.13 12.3 12.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain TFIIF_alpha PF05793.12 ETO32598.1 - 0.14 10.7 41.3 0.19 10.3 41.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) LAP1C PF05609.12 ETO32598.1 - 0.68 9.0 18.0 0.87 8.6 18.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) zf-RING_11 PF17123.5 ETO32598.1 - 1.7 8.5 6.6 0.26 11.1 0.3 2.5 2 0 0 2 2 2 0 RING-like zinc finger Nop14 PF04147.12 ETO32598.1 - 3.8 5.6 40.8 5.4 5.1 40.8 1.1 1 0 0 1 1 1 0 Nop14-like family CPSase_L_D2 PF02786.17 ETO32600.1 - 9e-09 35.1 0.0 4.4e-08 32.9 0.0 1.9 1 1 0 1 1 1 1 Carbamoyl-phosphate synthase L chain, ATP binding domain ATP-grasp_4 PF13535.6 ETO32600.1 - 1.4e-07 31.2 0.0 1.2e-06 28.2 0.0 2.2 1 1 0 1 1 1 1 ATP-grasp domain Nop14 PF04147.12 ETO32600.1 - 6.5e-05 21.4 19.8 0.00011 20.6 19.8 1.3 1 0 0 1 1 1 1 Nop14-like family ATP-grasp_3 PF02655.14 ETO32600.1 - 0.00022 21.3 0.0 0.00091 19.3 0.0 2.0 1 1 0 1 1 1 1 ATP-grasp domain ATPgrasp_Ter PF15632.6 ETO32600.1 - 0.0013 18.5 0.0 0.35 10.6 0.0 2.5 2 0 0 2 2 2 1 ATP-grasp in the biosynthetic pathway with Ter operon GARS_A PF01071.19 ETO32600.1 - 0.0013 18.5 0.0 0.0025 17.6 0.0 1.4 1 0 0 1 1 1 1 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain Astro_capsid_p PF12226.8 ETO32600.1 - 0.025 13.8 9.6 0.044 12.9 9.6 1.5 1 0 0 1 1 1 0 Turkey astrovirus capsid protein SDA1 PF05285.12 ETO32600.1 - 0.11 11.9 25.8 0.23 10.9 25.8 1.5 1 0 0 1 1 1 0 SDA1 Dala_Dala_lig_C PF07478.13 ETO32600.1 - 0.13 11.8 0.0 0.31 10.5 0.0 1.6 1 0 0 1 1 1 0 D-ala D-ala ligase C-terminus CDC45 PF02724.14 ETO32600.1 - 0.75 8.0 20.5 1.2 7.3 20.5 1.2 1 0 0 1 1 1 0 CDC45-like protein YL1 PF05764.13 ETO32600.1 - 3.2 7.8 27.1 0.73 9.9 23.4 1.7 2 0 0 2 2 2 0 YL1 nuclear protein RRN3 PF05327.11 ETO32600.1 - 4 5.9 20.2 0.25 9.9 14.7 1.7 2 0 0 2 2 2 0 RNA polymerase I specific transcription initiation factor RRN3 VWA_2 PF13519.6 ETO32601.1 - 8e-18 65.1 0.0 2.6e-17 63.4 0.0 1.9 1 0 0 1 1 1 1 von Willebrand factor type A domain Ssl1 PF04056.14 ETO32601.1 - 1.4e-05 25.0 0.1 2.7e-05 24.1 0.1 1.4 1 0 0 1 1 1 1 Ssl1-like VWA PF00092.28 ETO32601.1 - 0.0013 19.0 0.1 0.0023 18.2 0.1 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain UIM PF02809.20 ETO32601.1 - 0.021 14.7 8.7 0.46 10.5 1.6 2.7 2 0 0 2 2 2 0 Ubiquitin interaction motif TAF4 PF05236.14 ETO32602.1 - 0.035 13.9 8.0 0.041 13.6 8.0 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family DUF4662 PF15578.6 ETO32602.1 - 0.058 13.2 8.1 0.069 12.9 8.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4662) DUF2947 PF11163.8 ETO32603.1 - 0.023 14.6 0.1 0.035 14.0 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2947) WD40 PF00400.32 ETO32604.1 - 2.5e-33 113.5 17.0 3.5e-08 34.0 0.6 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32604.1 - 4.4e-13 49.3 0.0 0.0067 16.7 0.0 6.0 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32604.1 - 6.4e-06 25.4 1.2 0.27 10.2 0.2 4.6 2 2 3 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32604.1 - 1.5e-05 24.5 0.0 0.00011 21.6 0.0 2.3 2 0 0 2 2 2 1 WD40-like domain eIF2A PF08662.11 ETO32604.1 - 0.0094 15.8 0.6 1.5 8.6 0.2 3.0 1 1 0 2 2 2 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO32604.1 - 0.01 14.5 0.2 0.15 10.7 0.1 2.3 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Rav1p_C PF12234.8 ETO32605.1 - 6.6e-53 180.1 6.5 1.4e-52 179.0 6.5 1.4 1 0 0 1 1 1 1 RAVE protein 1 C terminal WD40 PF00400.32 ETO32605.1 - 0.0038 18.0 15.9 0.47 11.4 0.1 7.2 9 0 0 9 9 9 3 WD domain, G-beta repeat HSP20 PF00011.21 ETO32606.1 - 0.097 12.8 0.1 0.18 11.9 0.1 1.4 1 0 0 1 1 1 0 Hsp20/alpha crystallin family Sec5 PF15469.6 ETO32607.1 - 9.2e-18 64.7 8.5 1.7e-17 63.9 8.5 1.4 1 0 0 1 1 1 1 Exocyst complex component Sec5 Vps51 PF08700.11 ETO32607.1 - 5.9e-16 58.3 3.1 5.9e-16 58.3 3.1 3.0 3 1 1 4 4 4 1 Vps51/Vps67 Dor1 PF04124.12 ETO32607.1 - 2.4e-10 39.6 12.6 3.8e-10 39.0 12.6 1.2 1 0 0 1 1 1 1 Dor1-like family Zw10 PF06248.13 ETO32607.1 - 2.1e-06 26.6 7.2 3.3e-06 26.0 7.2 1.2 1 0 0 1 1 1 1 Centromere/kinetochore Zw10 Vps54_N PF10475.9 ETO32607.1 - 2.2e-06 27.2 8.0 4.2e-06 26.2 8.0 1.3 1 0 0 1 1 1 1 Vacuolar-sorting protein 54, of GARP complex COG2 PF06148.11 ETO32607.1 - 6e-06 26.4 3.4 7.6e-06 26.1 1.0 2.1 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 COG5 PF10392.9 ETO32607.1 - 5.5e-05 23.4 0.5 5.5e-05 23.4 0.5 2.7 2 1 0 2 2 2 1 Golgi transport complex subunit 5 Vps53_N PF04100.12 ETO32607.1 - 0.00031 19.8 7.5 0.00048 19.2 7.5 1.2 1 0 0 1 1 1 1 Vps53-like, N-terminal XhlA PF10779.9 ETO32607.1 - 0.042 14.1 0.8 0.042 14.1 0.8 2.2 3 0 0 3 3 2 0 Haemolysin XhlA DUF948 PF06103.11 ETO32607.1 - 0.56 10.5 2.2 1.4 9.2 0.7 2.5 2 1 0 2 2 2 0 Bacterial protein of unknown function (DUF948) Laminin_II PF06009.12 ETO32607.1 - 0.61 10.1 6.1 0.15 12.1 1.5 2.3 2 1 0 2 2 2 0 Laminin Domain II Fzo_mitofusin PF04799.13 ETO32608.1 - 0.026 14.1 7.6 0.055 13.0 7.6 1.6 1 0 0 1 1 1 0 fzo-like conserved region Hema_HEFG PF02710.14 ETO32608.1 - 0.085 13.1 0.0 0.15 12.2 0.0 1.4 1 0 0 1 1 1 0 Hemagglutinin domain of haemagglutinin-esterase-fusion glycoprotein NTP_transf_2 PF01909.23 ETO32608.1 - 0.11 12.7 1.8 0.18 12.1 0.1 2.2 2 2 1 3 3 3 0 Nucleotidyltransferase domain DHR10 PF18595.1 ETO32608.1 - 1.2 9.2 16.0 0.12 12.4 10.1 2.3 2 0 0 2 2 2 0 Designed helical repeat protein 10 domain Seryl_tRNA_N PF02403.22 ETO32608.1 - 1.5 9.1 20.2 0.063 13.5 9.7 3.0 2 1 1 3 3 3 0 Seryl-tRNA synthetase N-terminal domain FlaC_arch PF05377.11 ETO32608.1 - 6.3 7.3 10.7 23 5.5 6.6 3.4 1 1 3 4 4 4 0 Flagella accessory protein C (FlaC) A_deaminase PF00962.22 ETO32609.1 - 1.8e-06 27.5 0.0 2.5e-06 27.1 0.0 1.2 1 0 0 1 1 1 1 Adenosine/AMP deaminase PI3K_1B_p101 PF10486.9 ETO32609.1 - 0.015 13.1 0.1 0.027 12.3 0.0 1.4 1 1 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Ras PF00071.22 ETO32611.1 - 1e-51 174.8 5.2 7e-45 152.5 1.7 2.4 1 1 1 2 2 2 2 Ras family Roc PF08477.13 ETO32611.1 - 1.2e-27 96.5 4.5 1.3e-21 77.0 0.4 3.1 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO32611.1 - 5.9e-10 38.9 1.6 1.7e-08 34.1 0.4 2.4 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO32611.1 - 5.1e-07 29.4 0.1 6.8e-07 29.0 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain RNF220 PF15926.5 ETO32611.1 - 0.02 14.5 0.1 0.057 13.0 0.0 1.7 2 0 0 2 2 2 0 E3 ubiquitin-protein ligase RNF220 DUF3584 PF12128.8 ETO32613.1 - 0.00048 17.8 3.5 0.00057 17.6 3.5 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) KASH_CCD PF14662.6 ETO32613.1 - 0.0054 16.6 5.4 0.0067 16.3 5.4 1.1 1 0 0 1 1 1 1 Coiled-coil region of CCDC155 or KASH HALZ PF02183.18 ETO32613.1 - 0.026 14.7 3.4 0.026 14.7 3.4 2.6 3 0 0 3 3 3 0 Homeobox associated leucine zipper TolA_bind_tri PF16331.5 ETO32614.1 - 0.00023 21.2 1.4 0.00031 20.8 1.4 1.3 1 0 0 1 1 1 1 TolA binding protein trimerisation ZapD PF07072.11 ETO32614.1 - 0.0016 18.3 4.1 0.0017 18.1 4.1 1.0 1 0 0 1 1 1 1 Cell division protein CAS_CSE1 PF03378.15 ETO32614.1 - 0.012 14.2 1.8 0.012 14.1 1.8 1.0 1 0 0 1 1 1 0 CAS/CSE protein, C-terminus UPF0242 PF06785.11 ETO32614.1 - 0.046 13.8 7.4 0.056 13.5 7.4 1.1 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF16 PF01519.16 ETO32614.1 - 0.19 12.3 8.5 0.23 12.0 8.5 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF16 WD40 PF00400.32 ETO32615.1 - 8.1e-11 42.3 5.5 0.011 16.6 0.3 5.0 5 0 0 5 5 5 3 WD domain, G-beta repeat Leu_zip PF15294.6 ETO32615.1 - 1.2 8.6 34.4 3.4 7.1 0.0 2.9 2 1 0 2 2 2 0 Leucine zipper ADIP PF11559.8 ETO32615.1 - 1.5 8.9 36.9 0.66 10.0 17.5 3.1 1 1 2 3 3 3 0 Afadin- and alpha -actinin-Binding RP-C PF03428.13 ETO32615.1 - 3.4 7.3 8.5 1.1 8.9 1.2 2.4 2 0 0 2 2 2 0 Replication protein C N-terminal domain Prominin PF05478.11 ETO32615.1 - 7.4 4.4 14.8 11 3.8 14.8 1.2 1 0 0 1 1 1 0 Prominin Vip3A_N PF12495.8 ETO32615.1 - 8 6.3 7.8 2.3 8.1 0.5 2.5 2 1 1 3 3 3 0 Vegetative insecticide protein 3A N terminal Bac_RepA_C PF18008.1 ETO32616.1 - 0.13 12.6 0.4 0.13 12.6 0.4 2.1 2 1 1 3 3 3 0 Replication initiator protein A C-terminal domain WD40 PF00400.32 ETO32617.1 - 3.4e-14 53.0 10.4 5.3e-05 23.9 0.1 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat Ion_trans PF00520.31 ETO32618.1 - 3.4e-28 98.5 17.8 3.9e-28 98.3 17.8 1.0 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO32618.1 - 6.3e-06 25.1 10.7 0.0044 15.8 1.6 2.1 1 1 1 2 2 2 2 Polycystin cation channel PNTB PF02233.16 ETO32620.1 - 1.9e-183 610.6 24.8 2.5e-182 606.9 19.4 2.1 2 0 0 2 2 2 2 NAD(P) transhydrogenase beta subunit AlaDh_PNT_C PF01262.21 ETO32620.1 - 1.8e-75 252.9 0.1 3.8e-75 251.8 0.1 1.6 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain AlaDh_PNT_N PF05222.15 ETO32620.1 - 2.6e-43 147.6 0.0 4.8e-43 146.7 0.0 1.5 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, N-terminal domain PNTB_4TM PF12769.7 ETO32620.1 - 4.2e-31 107.3 2.6 4.2e-31 107.3 2.6 3.6 3 1 1 4 4 4 1 4TM region of pyridine nucleotide transhydrogenase, mitoch 2-Hacid_dh_C PF02826.19 ETO32620.1 - 0.0018 17.7 0.2 0.48 9.8 0.0 3.4 3 0 0 3 3 3 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Pyr_redox_2 PF07992.14 ETO32620.1 - 0.044 13.0 0.8 0.087 12.0 0.2 1.7 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Pkinase PF00069.25 ETO32621.1 - 2.1e-42 145.3 0.5 6.2e-31 107.7 0.5 2.3 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32621.1 - 1.7e-16 60.3 1.7 2.5e-13 49.9 0.2 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO32621.1 - 1.7e-05 24.3 0.4 0.0014 18.0 0.1 2.2 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ETO32621.1 - 7.5e-05 21.7 0.0 0.0001 21.2 0.0 1.4 1 1 0 1 1 1 1 Fungal protein kinase Pox_ser-thr_kin PF05445.11 ETO32621.1 - 0.00039 19.5 0.1 0.00062 18.9 0.1 1.3 1 0 0 1 1 1 1 Poxvirus serine/threonine protein kinase Nudc_N PF14050.6 ETO32621.1 - 1 9.4 4.5 14 5.8 0.4 2.9 2 0 0 2 2 2 0 N-terminal conserved domain of Nudc. PIP5K PF01504.18 ETO32622.1 - 3.5e-22 78.9 0.3 4e-22 78.7 0.3 1.0 1 0 0 1 1 1 1 Phosphatidylinositol-4-phosphate 5-Kinase DUF3246 PF11596.8 ETO32622.1 - 0.19 11.2 0.1 0.22 10.9 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3246) PIP5K PF01504.18 ETO32623.1 - 7.8e-30 104.0 2.0 1.1e-29 103.5 0.2 1.8 2 0 0 2 2 2 1 Phosphatidylinositol-4-phosphate 5-Kinase EZH2_N PF18601.1 ETO32623.1 - 0.049 14.0 0.7 0.092 13.1 0.7 1.4 1 0 0 1 1 1 0 EZH2 N-terminal domain Nop14 PF04147.12 ETO32624.1 - 0.012 13.9 7.8 0.014 13.7 7.8 1.1 1 0 0 1 1 1 0 Nop14-like family DNA_pol_phi PF04931.13 ETO32624.1 - 0.023 12.8 12.6 0.028 12.5 12.6 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO32624.1 - 0.11 10.8 6.7 0.13 10.6 6.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Sporozoite_P67 PF05642.11 ETO32624.1 - 0.4 8.7 6.4 0.51 8.4 6.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.6 ETO32624.1 - 0.62 9.7 2.9 1.4 8.6 2.9 1.7 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO32624.1 - 0.65 9.3 16.4 1.1 8.6 16.4 1.3 1 0 0 1 1 1 0 NOA36 protein Osteopontin PF00865.18 ETO32624.1 - 0.79 9.2 17.5 1.3 8.5 17.5 1.3 1 0 0 1 1 1 0 Osteopontin RRN3 PF05327.11 ETO32624.1 - 2.7 6.4 8.0 3.3 6.1 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DUF4637 PF15470.6 ETO32624.1 - 9.9 5.9 7.3 19 4.9 7.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF2207 PF09972.9 ETO32625.1 - 0.31 9.8 7.6 0.36 9.5 7.6 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Herpes_LMP1 PF05297.11 ETO32625.1 - 8.7 5.4 9.6 10 5.2 9.6 1.2 1 0 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Sdh_cyt PF01127.22 ETO32626.1 - 0.028 14.5 0.1 0.032 14.3 0.1 1.1 1 0 0 1 1 1 0 Succinate dehydrogenase/Fumarate reductase transmembrane subunit LYRIC PF15686.5 ETO32626.1 - 0.66 9.5 2.2 0.82 9.2 2.2 1.1 1 0 0 1 1 1 0 Lysine-rich CEACAM1 co-isolated protein family DivIC PF04977.15 ETO32627.1 - 0.00066 19.4 8.7 0.00066 19.4 8.7 2.5 3 0 0 3 3 3 1 Septum formation initiator Peroxin-13_N PF04088.13 ETO32627.1 - 0.0052 17.1 11.8 0.18 12.1 0.0 2.9 1 1 2 3 3 3 2 Peroxin 13, N-terminal region YqfD PF06898.11 ETO32627.1 - 0.0069 15.3 3.0 0.01 14.7 3.0 1.1 1 0 0 1 1 1 1 Putative stage IV sporulation protein YqfD PgaD PF13994.6 ETO32627.1 - 0.02 14.9 1.9 0.046 13.8 1.9 1.5 1 0 0 1 1 1 0 PgaD-like protein Monooxygenase_B PF04744.12 ETO32627.1 - 0.022 13.6 1.7 0.03 13.2 1.7 1.2 1 0 0 1 1 1 0 Monooxygenase subunit B protein NicO PF03824.16 ETO32627.1 - 0.089 12.1 2.1 0.35 10.2 0.3 2.1 1 1 1 2 2 2 0 High-affinity nickel-transport protein PigN PF04987.14 ETO32627.1 - 0.12 11.3 4.1 0.22 10.3 4.1 1.4 1 0 0 1 1 1 0 Phosphatidylinositolglycan class N (PIG-N) PSCyt3 PF07627.11 ETO32627.1 - 0.29 11.4 5.8 0.11 12.7 0.7 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF1588) Activator_LAG-3 PF11498.8 ETO32627.1 - 0.45 9.4 34.6 0.49 9.3 34.6 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 DUF4140 PF13600.6 ETO32627.1 - 0.63 10.5 8.2 0.35 11.3 2.6 2.2 2 0 0 2 2 2 0 N-terminal domain of unknown function (DUF4140) PspB PF06667.12 ETO32627.1 - 1.5 8.9 10.1 0.11 12.6 4.8 1.9 2 1 0 2 2 2 0 Phage shock protein B DUF4330 PF14221.6 ETO32627.1 - 1.7 8.8 6.9 2.9 8.1 6.9 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4330) Folliculin PF11704.8 ETO32627.1 - 3.4 7.5 12.0 37 4.1 12.0 2.0 1 1 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport DUF3040 PF11239.8 ETO32628.1 - 0.1 12.9 0.1 0.17 12.1 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3040) ABC2_membrane PF01061.24 ETO32628.1 - 0.23 10.8 7.4 0.42 10.0 7.4 1.3 1 0 0 1 1 1 0 ABC-2 type transporter DUF4577 PF15145.6 ETO32630.1 - 0.0021 18.1 0.1 0.0038 17.3 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) Lipase_3 PF01764.25 ETO32632.1 - 6.3e-17 61.8 0.0 1.2e-16 60.9 0.0 1.4 1 0 0 1 1 1 1 Lipase (class 3) Presenilin PF01080.17 ETO32633.1 - 3 6.5 10.6 4.5 5.9 10.6 1.2 1 0 0 1 1 1 0 Presenilin POP1 PF06978.11 ETO32633.1 - 5.1 7.0 13.2 11 5.9 13.2 1.7 1 1 0 1 1 1 0 Ribonucleases P/MRP protein subunit POP1 EF-hand_1 PF00036.32 ETO32635.1 - 9.1e-14 49.9 0.7 5.7e-06 25.5 0.2 2.8 2 0 0 2 2 2 2 EF hand EF-hand_7 PF13499.6 ETO32635.1 - 1.8e-11 44.3 4.1 3.7e-11 43.3 1.7 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO32635.1 - 1.3e-10 40.3 1.2 0.00013 21.6 0.0 3.4 4 1 0 4 4 4 2 EF-hand domain EF-hand_5 PF13202.6 ETO32635.1 - 1.8e-07 30.4 1.3 0.0056 16.1 0.0 2.4 2 0 0 2 2 2 2 EF hand EF-hand_8 PF13833.6 ETO32635.1 - 4.1e-06 26.5 3.9 0.00011 22.0 0.2 3.2 4 0 0 4 4 4 1 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO32635.1 - 0.0013 19.0 1.8 0.0024 18.2 1.0 1.8 2 0 0 2 2 2 1 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_4 PF12763.7 ETO32635.1 - 0.022 14.7 0.1 0.036 14.0 0.1 1.4 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand Pkinase PF00069.25 ETO32636.1 - 1.3e-43 149.3 3.9 9.8e-25 87.4 3.4 3.5 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32636.1 - 2.4e-16 59.8 3.1 5.4e-11 42.3 2.8 3.1 2 1 0 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ETO32636.1 - 4e-06 26.9 2.7 1.3e-05 25.2 0.0 2.4 3 0 0 3 3 3 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO32636.1 - 0.00021 20.7 0.8 0.0003 20.2 0.1 1.6 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Choline_kinase PF01633.20 ETO32636.1 - 0.00084 19.0 1.5 0.0011 18.6 0.2 1.8 2 0 0 2 2 2 1 Choline/ethanolamine kinase Kinase-like PF14531.6 ETO32636.1 - 0.001 18.4 0.5 0.95 8.7 0.0 2.5 3 0 0 3 3 3 2 Kinase-like RIO1 PF01163.22 ETO32636.1 - 0.0055 16.3 1.8 0.0057 16.3 0.1 1.8 2 0 0 2 2 2 1 RIO1 family YrbL-PhoP_reg PF10707.9 ETO32636.1 - 0.038 13.5 0.1 0.038 13.5 0.1 2.1 2 1 0 2 2 2 0 PhoP regulatory network protein YrbL FTA2 PF13095.6 ETO32636.1 - 0.043 13.4 0.7 2.2 7.8 0.1 2.5 2 0 0 2 2 2 0 Kinetochore Sim4 complex subunit FTA2 DUF4642 PF15484.6 ETO32637.1 - 0.00024 21.4 3.7 0.00039 20.7 3.7 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4642) DUF2052 PF09747.9 ETO32637.1 - 0.001 19.3 2.5 0.0013 18.9 2.5 1.2 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) DUF3824 PF12868.7 ETO32637.1 - 0.0013 19.4 3.4 0.0018 18.9 3.4 1.2 1 0 0 1 1 1 1 Domain of unknwon function (DUF3824) PI3K_1B_p101 PF10486.9 ETO32637.1 - 0.0071 14.2 0.9 0.0086 13.9 0.9 1.0 1 0 0 1 1 1 1 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Cas_Csy4 PF09618.10 ETO32637.1 - 0.01 16.0 0.5 0.013 15.7 0.5 1.2 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) ORC6 PF05460.13 ETO32637.1 - 0.019 14.3 5.5 0.024 13.9 5.5 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) SDA1 PF05285.12 ETO32637.1 - 0.025 14.0 6.9 0.032 13.7 6.9 1.1 1 0 0 1 1 1 0 SDA1 FAM176 PF14851.6 ETO32637.1 - 0.037 13.7 3.7 0.057 13.1 3.7 1.3 1 0 0 1 1 1 0 FAM176 family Dzip-like_N PF13815.6 ETO32637.1 - 0.066 13.2 4.9 0.11 12.5 4.9 1.3 1 0 0 1 1 1 0 Iguana/Dzip1-like DAZ-interacting protein N-terminal LRRC37AB_C PF14914.6 ETO32637.1 - 0.076 12.9 2.5 0.12 12.3 2.5 1.2 1 0 0 1 1 1 0 LRRC37A/B like protein 1 C-terminal domain DUF3886 PF13025.6 ETO32637.1 - 0.089 13.0 16.3 0.16 12.2 16.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3886) Cytomega_UL84 PF06284.11 ETO32637.1 - 0.096 11.1 0.1 0.1 11.1 0.1 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein CDC45 PF02724.14 ETO32637.1 - 0.1 10.8 2.4 0.11 10.8 2.4 1.1 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO32637.1 - 0.13 10.3 4.7 0.17 9.9 4.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Presenilin PF01080.17 ETO32637.1 - 0.67 8.7 2.0 0.76 8.5 2.0 1.2 1 0 0 1 1 1 0 Presenilin CMS1 PF14617.6 ETO32637.1 - 0.98 8.7 3.6 1.4 8.2 3.6 1.2 1 0 0 1 1 1 0 U3-containing 90S pre-ribosomal complex subunit Hydin_ADK PF17213.3 ETO32638.1 - 0.059 13.6 0.7 0.059 13.6 0.7 2.1 2 0 0 2 2 2 0 Hydin Adenylate kinase-like domain NST1 PF13945.6 ETO32638.1 - 0.16 12.1 37.7 0.11 12.5 30.5 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator Dapper PF15268.6 ETO32638.1 - 0.91 8.3 24.5 1.1 8.0 24.5 1.0 1 0 0 1 1 1 0 Dapper ASD2 PF08687.11 ETO32638.1 - 2.4 7.6 16.6 2.5 7.6 15.4 1.5 1 1 0 1 1 1 0 Apx/Shroom domain ASD2 SAA PF00277.18 ETO32639.1 - 0.091 13.2 0.0 0.14 12.7 0.0 1.3 1 0 0 1 1 1 0 Serum amyloid A protein PDR_CDR PF06422.12 ETO32640.1 - 0.34 10.9 2.3 15 5.6 0.2 2.4 2 0 0 2 2 2 0 CDR ABC transporter DeoRC PF00455.22 ETO32641.1 - 0.014 15.4 0.1 6.4 6.7 0.0 2.3 2 0 0 2 2 2 0 DeoR C terminal sensor domain DUF3301 PF11743.8 ETO32641.1 - 0.11 12.1 0.2 0.51 10.1 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3301) DNA_pol_A_exo1 PF01612.20 ETO32642.1 - 1.7e-19 70.2 0.0 2.7e-19 69.6 0.0 1.3 1 0 0 1 1 1 1 3'-5' exonuclease PelG PF16933.5 ETO32643.1 - 0.18 10.6 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Putative exopolysaccharide Exporter (EPS-E) ORC_WH_C PF18137.1 ETO32645.1 - 3.1 7.9 10.7 4.7 7.3 10.7 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal Presenilin PF01080.17 ETO32645.1 - 7.2 5.3 6.4 7.4 5.2 6.4 1.1 1 0 0 1 1 1 0 Presenilin Serine_rich PF08824.10 ETO32646.1 - 0.051 13.6 0.2 0.11 12.5 0.0 1.5 2 0 0 2 2 2 0 Serine rich protein interaction domain YojJ PF10372.9 ETO32647.1 - 0.001 19.1 0.2 0.19 11.8 0.0 2.6 2 0 0 2 2 2 2 Bacterial membrane-spanning protein N-terminus AAA_9 PF12781.7 ETO32647.1 - 0.0058 15.8 0.5 0.009 15.2 0.0 1.5 2 0 0 2 2 2 1 ATP-binding dynein motor region Calici_coat_C PF08435.11 ETO32647.1 - 0.078 12.5 0.0 0.098 12.2 0.0 1.2 1 0 0 1 1 1 0 Calicivirus coat protein C-terminal Mem_trans PF03547.18 ETO32648.1 - 0.44 8.9 1.9 0.49 8.7 1.9 1.1 1 0 0 1 1 1 0 Membrane transport protein DUF4266 PF14086.6 ETO32648.1 - 0.5 11.4 0.3 0.5 11.4 0.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4266) TP53IP5 PF15331.6 ETO32648.1 - 2.6 8.1 8.9 3 7.9 8.9 1.0 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 Pkinase PF00069.25 ETO32649.1 - 3.7e-37 128.1 0.0 2.2e-31 109.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO32649.1 - 1.2e-22 80.4 0.0 1.3e-20 73.8 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO32649.1 - 0.0038 16.6 0.0 0.67 9.2 0.0 2.4 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ETO32649.1 - 0.013 15.4 0.2 0.029 14.3 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family MOSC_N PF03476.16 ETO32651.1 - 0.029 14.3 1.1 0.037 13.9 0.5 1.5 1 1 1 2 2 2 0 MOSC N-terminal beta barrel domain Lon_C PF05362.13 ETO32651.1 - 0.13 11.8 0.0 0.19 11.2 0.0 1.2 1 0 0 1 1 1 0 Lon protease (S16) C-terminal proteolytic domain MAP17 PF15807.5 ETO32651.1 - 0.41 10.9 6.6 0.19 11.9 4.5 1.5 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 adh_short PF00106.25 ETO32654.1 - 5.8e-45 153.2 0.0 8.1e-45 152.7 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO32654.1 - 6.7e-31 107.6 0.0 1.7e-30 106.3 0.0 1.5 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO32654.1 - 1.3e-13 51.3 0.1 1.8e-13 50.8 0.1 1.2 1 0 0 1 1 1 1 KR domain FixQ PF05545.11 ETO32654.1 - 1.6 8.8 4.6 2.2 8.3 0.2 2.5 2 0 0 2 2 2 0 Cbb3-type cytochrome oxidase component FixQ DUF1282 PF06930.12 ETO32655.1 - 0.016 15.0 3.3 0.033 14.0 3.3 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1282) rRNA_processing PF08524.11 ETO32656.1 - 0.12 12.4 2.9 0.21 11.6 2.9 1.3 1 0 0 1 1 1 0 rRNA processing RP-C_C PF11800.8 ETO32656.1 - 0.14 12.2 2.5 0.22 11.6 2.5 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region NST1 PF13945.6 ETO32656.1 - 6 6.9 20.9 11 6.1 20.9 1.4 1 0 0 1 1 1 0 Salt tolerance down-regulator DUF736 PF05284.12 ETO32657.1 - 0.042 13.7 0.0 0.09 12.7 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF736) DUF493 PF04359.14 ETO32658.1 - 0.0032 18.0 0.8 1.4 9.6 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF493) Kinesin PF00225.23 ETO32660.1 - 4.3e-13 48.9 1.6 8.4e-13 47.9 1.6 1.5 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO32660.1 - 1.7e-07 31.3 0.9 1.7e-07 31.3 0.9 2.1 2 1 0 2 2 2 1 Microtubule binding Sulfatase PF00884.23 ETO32661.1 - 1.3e-53 182.4 4.0 2.6e-53 181.5 4.0 1.5 1 1 0 1 1 1 1 Sulfatase Phosphodiest PF01663.22 ETO32661.1 - 0.0037 16.9 0.3 0.033 13.8 0.0 2.3 2 1 0 2 2 2 1 Type I phosphodiesterase / nucleotide pyrophosphatase Sulfatase_C PF14707.6 ETO32661.1 - 0.036 14.8 0.0 0.16 12.7 0.0 2.1 2 0 0 2 2 2 0 C-terminal region of aryl-sulfatase DUF4407 PF14362.6 ETO32661.1 - 0.21 10.9 0.2 0.4 10.0 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4834 PF16118.5 ETO32661.1 - 0.4 11.7 3.0 19 6.3 0.3 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CALM_bind PF16025.5 ETO32661.1 - 1.2 9.6 6.3 2.9 8.4 6.3 1.6 1 0 0 1 1 1 0 Calcium-dependent calmodulin binding Peroxin-13_N PF04088.13 ETO32661.1 - 3.2 8.0 5.5 25 5.1 1.1 2.3 2 0 0 2 2 2 0 Peroxin 13, N-terminal region zf-CCCH PF00642.24 ETO32662.1 - 2.2e-07 30.6 4.4 3.3e-07 30.0 4.4 1.3 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO32662.1 - 0.0054 16.7 6.5 0.012 15.7 6.5 1.6 1 0 0 1 1 1 1 Zinc finger domain Transpos_assoc PF13963.6 ETO32663.1 - 0.0024 18.2 1.3 0.0076 16.5 0.6 2.2 2 0 0 2 2 2 1 Transposase-associated domain PPP4R2 PF09184.11 ETO32663.1 - 1.1 8.8 12.0 0.047 13.3 4.5 2.0 2 0 0 2 2 2 0 PPP4R2 DUF4187 PF13821.6 ETO32664.1 - 0.01 15.6 0.0 0.024 14.4 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4187) V_ATPase_I PF01496.19 ETO32665.1 - 5.2e-34 117.3 4.2 5.8e-34 117.2 4.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family MscS_porin PF12795.7 ETO32665.1 - 0.003 17.1 1.5 0.003 17.1 1.5 1.5 2 0 0 2 2 2 1 Mechanosensitive ion channel porin domain Angiomotin_C PF12240.8 ETO32665.1 - 0.017 14.7 4.0 1.8 8.1 0.1 2.9 3 0 0 3 3 3 0 Angiomotin C terminal DUF3287 PF11690.8 ETO32665.1 - 0.083 12.6 6.5 2.9 7.6 0.0 4.0 4 1 0 4 4 4 0 Protein of unknown function (DUF3287) DUF4315 PF14193.6 ETO32665.1 - 0.11 12.5 6.6 0.74 9.9 1.0 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) Vir_act_alpha_C PF10400.9 ETO32665.1 - 0.49 11.1 4.6 37 5.1 0.0 3.3 3 0 0 3 3 3 0 Virulence activator alpha C-term DUF4200 PF13863.6 ETO32665.1 - 6.8 7.1 10.9 0.22 11.9 4.2 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) Actin PF00022.19 ETO32667.1 - 6.8e-45 153.4 0.0 8e-39 133.4 0.0 2.0 2 0 0 2 2 2 2 Actin Actin PF00022.19 ETO32668.1 - 9.9e-18 63.9 0.0 1.2e-17 63.7 0.0 1.0 1 0 0 1 1 1 1 Actin Peptidase_C48 PF02902.19 ETO32673.1 - 9.6e-29 100.8 0.9 9.6e-29 100.8 0.9 2.1 2 0 0 2 2 2 1 Ulp1 protease family, C-terminal catalytic domain Peptidase_C57 PF03290.13 ETO32673.1 - 0.0063 15.3 6.6 0.043 12.5 0.6 2.3 1 1 1 2 2 2 2 Vaccinia virus I7 processing peptidase GCR1_C PF12550.8 ETO32673.1 - 0.026 14.8 2.6 0.026 14.8 2.6 2.5 2 1 0 2 2 2 0 Transcriptional activator of glycolytic enzymes DUF4672 PF15716.5 ETO32673.1 - 0.51 9.9 3.5 0.99 9.0 3.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4672) DUF4890 PF16231.5 ETO32674.1 - 0.1 13.1 0.1 0.1 13.1 0.1 2.4 2 1 1 3 3 3 0 Domain of unknown function (DUF4890) YscO PF07321.12 ETO32674.1 - 0.2 11.6 4.3 0.14 12.1 0.5 2.1 2 0 0 2 2 2 0 Type III secretion protein YscO ALMT PF11744.8 ETO32674.1 - 2.3 6.9 6.2 3.3 6.4 6.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter HMG_box PF00505.19 ETO32674.1 - 3.2 8.2 5.3 0.99 9.9 0.6 2.3 2 0 0 2 2 2 0 HMG (high mobility group) box TP_methylase PF00590.20 ETO32675.1 - 0.26 11.2 0.0 0.32 10.9 0.0 1.1 1 0 0 1 1 1 0 Tetrapyrrole (Corrin/Porphyrin) Methylases Telomere_Sde2_2 PF13297.6 ETO32678.1 - 2.9e-23 81.3 0.1 5.1e-23 80.5 0.1 1.4 1 0 0 1 1 1 1 Telomere stability C-terminal GPS PF01825.21 ETO32679.1 - 0.026 15.1 0.0 0.054 14.0 0.0 1.6 1 0 0 1 1 1 0 GPCR proteolysis site, GPS, motif DUF2457 PF10446.9 ETO32680.1 - 0.035 13.2 12.8 0.046 12.9 12.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Menin PF05053.13 ETO32680.1 - 0.049 12.0 6.0 0.057 11.8 6.0 1.1 1 0 0 1 1 1 0 Menin CPSF100_C PF13299.6 ETO32680.1 - 0.074 13.2 0.5 0.097 12.9 0.5 1.1 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Zip PF02535.22 ETO32680.1 - 0.078 12.2 0.5 0.1 11.8 0.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO32680.1 - 0.12 11.1 2.1 0.18 10.6 2.1 1.2 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ETO32680.1 - 0.22 11.2 1.8 0.33 10.6 1.8 1.3 1 0 0 1 1 1 0 FAM176 family PDCD2_C PF04194.13 ETO32680.1 - 0.27 11.3 3.8 0.4 10.7 3.8 1.2 1 0 0 1 1 1 0 Programmed cell death protein 2, C-terminal putative domain NST1 PF13945.6 ETO32680.1 - 0.32 11.1 21.3 0.061 13.4 17.9 1.4 2 0 0 2 2 2 0 Salt tolerance down-regulator DUF2076 PF09849.9 ETO32680.1 - 1.1 9.3 11.6 1.4 8.9 11.6 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RasGEF PF00617.19 ETO32681.1 - 1.8e-11 44.6 0.3 6.3e-11 42.8 0.0 1.8 1 1 0 2 2 2 1 RasGEF domain Asp PF00026.23 ETO32682.1 - 9.7e-06 25.2 0.0 9.7e-06 25.2 0.0 2.7 2 1 0 2 2 2 1 Eukaryotic aspartyl protease RseC_MucC PF04246.12 ETO32682.1 - 0.079 12.9 0.2 2.9 7.9 0.0 2.3 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Kelch_1 PF01344.25 ETO32683.1 - 1.1e-11 44.1 10.2 0.049 13.2 0.2 6.5 6 2 0 6 6 6 5 Kelch motif Kelch_6 PF13964.6 ETO32683.1 - 5e-10 39.3 3.9 0.012 15.8 0.1 5.5 5 1 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ETO32683.1 - 7.4e-07 29.0 1.5 0.012 15.6 0.2 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO32683.1 - 0.00066 19.6 3.7 1.7 8.7 0.0 5.2 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO32683.1 - 0.0018 18.5 7.6 1.5 9.2 0.0 4.4 4 1 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO32683.1 - 0.0083 16.1 3.4 2.7 8.1 0.5 4.4 4 1 0 4 4 4 1 Kelch motif PQQ_3 PF13570.6 ETO32683.1 - 0.29 11.7 1.3 37 5.0 0.1 3.0 2 0 0 2 2 2 0 PQQ-like domain TLD PF07534.16 ETO32684.1 - 2.2e-08 34.4 0.3 6.5e-08 32.9 0.3 1.8 1 0 0 1 1 1 1 TLD fn3 PF00041.21 ETO32684.1 - 0.0039 17.5 0.2 0.016 15.6 0.1 2.1 2 0 0 2 2 2 1 Fibronectin type III domain ApoLp-III PF07464.11 ETO32684.1 - 0.0043 17.2 5.5 0.0092 16.1 5.5 1.5 1 0 0 1 1 1 1 Apolipophorin-III precursor (apoLp-III) CARD PF00619.21 ETO32684.1 - 0.031 14.3 0.5 0.031 14.3 0.5 2.0 2 0 0 2 2 2 0 Caspase recruitment domain Baculo_PEP_C PF04513.12 ETO32684.1 - 0.13 12.3 1.2 0.25 11.4 1.2 1.4 1 0 0 1 1 1 0 Baculovirus polyhedron envelope protein, PEP, C terminus Apolipoprotein PF01442.18 ETO32684.1 - 0.18 11.6 8.7 0.37 10.6 8.7 1.4 1 1 0 1 1 1 0 Apolipoprotein A1/A4/E domain DNA_topoisoIV PF00521.20 ETO32684.1 - 0.2 10.5 6.9 0.34 9.7 6.9 1.3 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A DUF1759 PF03564.15 ETO32684.1 - 0.51 10.3 5.2 0.62 10.0 0.4 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1759) Exonuc_VII_L PF02601.15 ETO32684.1 - 0.87 9.1 5.6 1.4 8.4 5.6 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit NPV_P10 PF05531.12 ETO32684.1 - 1.2 9.7 3.5 8.2 7.0 1.3 2.5 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein SOAR PF16533.5 ETO32684.1 - 1.4 8.9 13.9 0.15 12.0 8.2 2.2 2 0 0 2 2 2 0 STIM1 Orai1-activating region BLOC1_2 PF10046.9 ETO32684.1 - 2 8.8 10.6 0.8 10.0 3.1 2.5 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Sulfotransfer_1 PF00685.27 ETO32686.1 - 2.4e-23 83.0 0.9 3.1e-23 82.6 0.9 1.1 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO32686.1 - 2.6e-06 28.0 0.1 3.8e-06 27.4 0.1 1.2 1 0 0 1 1 1 1 Sulfotransferase family DUF281 PF03436.13 ETO32686.1 - 0.81 10.1 5.0 0.45 11.0 0.6 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF281) Sulfotransfer_1 PF00685.27 ETO32687.1 - 5.4e-16 58.9 0.1 6.3e-16 58.7 0.1 1.0 1 0 0 1 1 1 1 Sulfotransferase domain RasGEF_N_2 PF14663.6 ETO32687.1 - 0.13 12.7 0.0 0.17 12.3 0.0 1.3 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Kelch_1 PF01344.25 ETO32688.1 - 1.8e-11 43.4 2.0 0.00029 20.3 0.2 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_6 PF13964.6 ETO32688.1 - 4.1e-09 36.4 7.3 0.022 15.0 0.2 4.4 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETO32688.1 - 1.2e-07 31.6 0.0 0.00077 19.4 0.0 3.2 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO32688.1 - 4.9e-06 26.4 3.6 0.17 11.9 0.3 4.6 6 0 0 6 6 6 3 Kelch motif Kelch_2 PF07646.15 ETO32688.1 - 9.3e-06 25.4 5.1 0.065 13.2 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO32688.1 - 0.0036 17.5 0.1 1.1 9.6 0.0 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain WD40 PF00400.32 ETO32689.1 - 1.7e-126 408.4 32.4 1e-08 35.6 0.0 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32689.1 - 1.9e-32 111.4 18.3 0.0027 18.0 0.0 13.0 1 1 11 14 14 14 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32689.1 - 8.3e-20 71.0 5.7 0.28 10.1 0.0 11.9 2 2 10 13 13 13 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32689.1 - 2.2e-15 56.8 12.8 0.0067 15.8 0.3 8.4 2 2 7 10 10 10 5 WD40-like domain Nup160 PF11715.8 ETO32689.1 - 7.1e-15 54.6 34.5 0.76 8.3 0.1 14.2 2 2 10 15 15 15 9 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO32689.1 - 3.9e-07 29.7 13.0 3.8 6.8 0.0 8.9 3 3 5 8 8 8 2 Neuroblastoma-amplified sequence, N terminal Pentapeptide PF00805.22 ETO32689.1 - 4.2e-07 29.5 2.4 1.5e-06 27.8 2.2 1.9 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO32689.1 - 0.00013 22.1 0.6 0.00071 19.7 0.1 2.5 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) PQQ_2 PF13360.6 ETO32689.1 - 0.0011 18.6 4.0 1.3 8.5 0.0 3.9 2 2 1 4 4 4 2 PQQ-like domain Pentapeptide_3 PF13576.6 ETO32689.1 - 0.0037 17.4 0.3 0.019 15.1 0.2 2.2 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) DUF1652 PF07865.11 ETO32689.1 - 0.0076 16.0 0.1 7.4 6.5 0.0 5.0 5 1 1 6 6 6 1 Protein of unknown function (DUF1652) DUF1513 PF07433.11 ETO32689.1 - 0.011 14.8 0.1 0.49 9.4 0.0 3.6 4 1 1 5 5 5 0 Protein of unknown function (DUF1513) Cytochrom_D1 PF02239.16 ETO32689.1 - 0.014 13.9 4.5 2.8 6.4 0.1 5.2 3 3 2 7 7 7 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO32689.1 - 0.16 12.0 18.7 7.7 6.6 0.2 7.7 10 0 0 10 10 10 0 WD40-like Beta Propeller Repeat Cupin_8 PF13621.6 ETO32690.1 - 4.1e-14 52.9 4.7 4.1e-14 52.9 4.7 2.0 2 1 0 2 2 2 1 Cupin-like domain Cupin_4 PF08007.12 ETO32690.1 - 0.00086 18.9 0.8 0.0019 17.7 0.8 1.9 1 1 0 1 1 1 1 Cupin superfamily protein GPI PF06560.11 ETO32690.1 - 0.011 15.0 0.1 0.024 13.9 0.1 1.5 1 0 0 1 1 1 0 Glucose-6-phosphate isomerase (GPI) JmjC PF02373.22 ETO32690.1 - 0.028 14.9 4.1 0.062 13.7 1.2 2.7 2 0 0 2 2 2 0 JmjC domain, hydroxylase GramPos_pilinD1 PF16555.5 ETO32690.1 - 5.2 7.2 7.5 0.65 10.2 2.0 2.1 2 0 0 2 2 2 0 Gram-positive pilin subunit D1, N-terminal domain ParcG PF10274.9 ETO32691.1 - 7.5e-08 32.7 1.0 0.0021 18.2 0.1 2.9 2 1 1 3 3 3 2 Parkin co-regulated protein DUF3385 PF11865.8 ETO32691.1 - 7.4e-05 22.7 3.0 0.0013 18.6 0.1 3.7 3 2 0 3 3 3 1 Domain of unknown function (DUF3385) HEAT PF02985.22 ETO32691.1 - 0.00053 20.0 0.0 0.19 12.0 0.0 3.9 3 0 0 3 3 3 1 HEAT repeat MMS19_C PF12460.8 ETO32691.1 - 0.00055 19.2 7.4 0.32 10.0 0.4 3.6 2 1 2 4 4 4 2 RNAPII transcription regulator C-terminal Cnd1 PF12717.7 ETO32691.1 - 0.002 18.2 0.7 0.016 15.2 0.2 2.5 2 0 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 IFRD PF05004.13 ETO32691.1 - 0.0027 16.9 8.3 0.75 8.8 0.1 3.7 3 1 1 4 4 4 3 Interferon-related developmental regulator (IFRD) Phage_int_SAM_5 PF13102.6 ETO32691.1 - 0.0028 18.0 0.3 11 6.4 0.0 4.2 4 1 0 4 4 4 1 Phage integrase SAM-like domain DCB PF16213.5 ETO32691.1 - 0.0044 16.7 4.8 0.0047 16.6 1.6 2.5 3 0 0 3 3 3 1 Dimerisation and cyclophilin-binding domain of Mon2 HEAT_EZ PF13513.6 ETO32691.1 - 0.0098 16.4 0.0 1.4 9.5 0.0 3.7 4 0 0 4 4 4 1 HEAT-like repeat Ipi1_N PF12333.8 ETO32691.1 - 0.047 14.3 6.1 3.3 8.3 0.6 3.7 3 1 1 4 4 3 0 Rix1 complex component involved in 60S ribosome maturation UME PF08064.13 ETO32691.1 - 0.092 12.7 2.2 2.7 8.0 0.0 3.7 3 1 1 4 4 4 0 UME (NUC010) domain HEAT_2 PF13646.6 ETO32691.1 - 0.096 13.1 0.0 4.5 7.7 0.0 3.3 3 1 0 3 3 3 0 HEAT repeats NUC173 PF08161.12 ETO32691.1 - 0.099 12.3 1.8 11 5.6 0.1 3.8 3 2 0 4 4 4 0 NUC173 domain FIT1_2 PF17357.2 ETO32691.1 - 0.24 11.5 3.0 0.51 10.5 3.0 1.4 1 0 0 1 1 1 0 Facilitor Of iron transport 1 and 2 V-ATPase_H_C PF11698.8 ETO32691.1 - 0.36 10.9 2.8 2.3 8.3 0.4 3.1 3 0 0 3 3 3 0 V-ATPase subunit H PolyA_pol_RNAbd PF12627.7 ETO32693.1 - 0.26 11.1 0.8 0.43 10.4 0.1 1.7 2 0 0 2 2 2 0 Probable RNA and SrmB- binding site of polymerase A zf-C2H2_7 PF15269.6 ETO32694.1 - 1.3 9.2 8.5 3.7 7.7 0.6 2.7 2 1 1 3 3 3 0 Zinc-finger WD40 PF00400.32 ETO32695.1 - 9.2e-07 29.5 1.1 0.00024 21.9 0.4 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat MRP-S32 PF10210.9 ETO32697.1 - 0.059 13.9 0.4 0.13 12.8 0.1 1.7 2 0 0 2 2 2 0 Mitochondrial 28S ribosomal protein S32 WD40 PF00400.32 ETO32698.1 - 6e-18 64.9 3.3 1.7e-05 25.4 0.3 4.6 5 0 0 5 5 5 4 WD domain, G-beta repeat WD40_like PF17005.5 ETO32698.1 - 2.1e-05 24.0 2.6 2.1e-05 24.0 2.6 1.9 2 0 0 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO32698.1 - 6.5e-05 23.2 1.4 0.017 15.4 0.3 3.0 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO32699.1 - 3.9e-33 113.0 21.0 6e-07 30.1 0.7 7.1 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32699.1 - 1.8e-08 34.6 3.2 0.0089 16.3 0.0 5.0 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32699.1 - 3.2e-08 32.7 7.7 0.016 13.9 0.9 5.0 3 3 1 4 4 4 3 Nucleoporin Nup120/160 CEL_III_C PF18054.1 ETO32700.1 - 3.4 7.7 7.3 1.4 9.0 3.2 2.0 1 1 1 2 2 2 0 CEL-III C-terminal B56 PF01603.20 ETO32701.1 - 6.8e-76 255.9 8.0 6.8e-76 255.9 8.0 1.8 2 0 0 2 2 2 1 Protein phosphatase 2A regulatory B subunit (B56 family) CAP_GLY PF01302.25 ETO32702.1 - 1.3e-15 57.1 0.6 3.8e-15 55.6 0.6 1.8 1 0 0 1 1 1 1 CAP-Gly domain YL1 PF05764.13 ETO32702.1 - 0.43 10.6 47.1 0.021 14.9 32.5 2.5 2 0 0 2 2 2 0 YL1 nuclear protein Ribonuc_L-PSP PF01042.21 ETO32703.1 - 7.5e-40 135.7 0.1 1.1e-39 135.2 0.1 1.2 1 0 0 1 1 1 1 Endoribonuclease L-PSP PGM_PMM_II PF02879.16 ETO32703.1 - 0.13 12.9 0.1 0.25 12.0 0.1 1.5 1 1 0 1 1 1 0 Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II Menin PF05053.13 ETO32704.1 - 0.028 12.8 0.1 0.028 12.8 0.1 1.9 2 0 0 2 2 2 0 Menin RIFIN PF02009.16 ETO32704.1 - 0.59 10.0 9.5 0.072 13.0 2.9 2.2 1 1 1 2 2 2 0 Rifin Tristanin_u2 PF16638.5 ETO32704.1 - 2.6 8.9 10.8 3.1 8.6 1.8 2.5 2 0 0 2 2 2 0 Unstructured region on methyltransferase between zinc-fingers FAM176 PF14851.6 ETO32704.1 - 2.8 7.6 5.7 7.4 6.2 2.6 2.5 2 0 0 2 2 2 0 FAM176 family TRAM_LAG1_CLN8 PF03798.16 ETO32705.1 - 0.00064 19.5 1.8 0.0013 18.5 1.8 1.5 1 0 0 1 1 1 1 TLC domain SID-1_RNA_chan PF13965.6 ETO32705.1 - 0.062 11.7 0.8 0.081 11.3 0.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF2347 PF09804.9 ETO32705.1 - 0.19 11.3 6.8 0.23 11.0 5.8 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2347) Presenilin PF01080.17 ETO32705.1 - 2.7 6.6 9.4 3.9 6.2 9.4 1.1 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO32705.1 - 3.3 7.7 5.5 18 5.3 4.1 2.0 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region Rota_VP2 PF05087.12 ETO32705.1 - 3.5 5.6 8.2 4.6 5.3 8.2 1.0 1 0 0 1 1 1 0 Rotavirus VP2 protein SLATT_5 PF18160.1 ETO32705.1 - 5.8 6.2 7.4 12 5.2 7.4 1.5 1 0 0 1 1 1 0 SMODS and SLOG-associating 2TM effector domain family 5 CDC45 PF02724.14 ETO32708.1 - 0.085 11.1 12.4 0.098 10.9 12.4 1.0 1 0 0 1 1 1 0 CDC45-like protein DNA_pol_phi PF04931.13 ETO32708.1 - 4.4 5.3 10.3 5.7 4.9 10.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi CENP-B_dimeris PF09026.10 ETO32708.1 - 6.1 7.3 11.4 12 6.3 11.4 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Neur_chan_memb PF02932.16 ETO32708.1 - 6.6 6.7 7.2 9.8 6.1 7.2 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region YL1 PF05764.13 ETO32709.1 - 0.0016 18.6 25.3 0.0019 18.4 25.3 1.1 1 0 0 1 1 1 1 YL1 nuclear protein Nop14 PF04147.12 ETO32709.1 - 0.12 10.6 19.4 0.14 10.3 19.4 1.0 1 0 0 1 1 1 0 Nop14-like family CDC45 PF02724.14 ETO32709.1 - 0.14 10.4 24.6 0.19 10.0 24.6 1.1 1 0 0 1 1 1 0 CDC45-like protein CLN3 PF02487.17 ETO32709.1 - 0.28 10.2 1.4 0.34 9.9 1.4 1.2 1 0 0 1 1 1 0 CLN3 protein RR_TM4-6 PF06459.12 ETO32709.1 - 1.6 8.5 12.2 2.8 7.7 12.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Neur_chan_memb PF02932.16 ETO32709.1 - 2.3 8.2 7.4 3.3 7.7 7.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Ran_BP1 PF00638.18 ETO32710.1 - 0.0011 19.2 1.3 0.012 15.8 0.2 2.6 2 1 0 2 2 2 1 RanBP1 domain Menin PF05053.13 ETO32710.1 - 0.34 9.2 8.0 0.37 9.1 8.0 1.2 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO32710.1 - 6.5 7.4 14.7 3.1 8.4 11.4 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain ArfGap PF01412.18 ETO32712.1 - 4.4e-31 107.4 2.2 4.7e-31 107.3 0.1 1.8 1 1 1 2 2 2 1 Putative GTPase activating protein for Arf Glyco_trans_4_4 PF13579.6 ETO32712.1 - 0.19 12.2 0.0 0.22 11.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyl transferase 4-like domain Keratin_2_head PF16208.5 ETO32713.1 - 1.4 9.1 6.3 0.54 10.4 2.9 1.8 2 0 0 2 2 2 0 Keratin type II head DUF5126 PF17166.4 ETO32715.1 - 0.026 14.4 0.1 0.058 13.3 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF5126) SYCP2_ARLD PF18581.1 ETO32715.1 - 0.14 12.2 0.8 0.24 11.4 0.1 1.7 2 0 0 2 2 2 0 Synaptonemal complex 2 armadillo-repeat-like domain MJ1316 PF04457.12 ETO32717.1 - 2.2e-08 34.7 0.2 4.6e-08 33.7 0.2 1.6 1 0 0 1 1 1 1 MJ1316 RNA cyclic group end recognition domain PhyH PF05721.13 ETO32717.1 - 0.0056 17.0 0.0 0.034 14.4 0.0 2.1 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) HSP70 PF00012.20 ETO32718.1 - 1e-18 66.9 0.0 2.6e-11 42.4 0.0 2.0 1 1 1 2 2 2 2 Hsp70 protein MreB_Mbl PF06723.13 ETO32718.1 - 5.8e-06 25.4 0.0 0.019 13.8 0.0 2.1 2 0 0 2 2 2 2 MreB/Mbl protein PsbT PF01405.17 ETO32720.1 - 2.4 8.0 8.2 5.4 6.9 8.2 1.6 1 0 0 1 1 1 0 Photosystem II reaction centre T protein RIBIOP_C PF04950.12 ETO32721.1 - 0.017 14.6 1.9 0.025 14.0 1.9 1.1 1 0 0 1 1 1 0 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal Flavokinase PF01687.17 ETO32721.1 - 0.032 14.5 0.3 0.086 13.2 0.2 1.8 2 0 0 2 2 2 0 Riboflavin kinase Aldo_ket_red PF00248.21 ETO32723.1 - 6.6e-22 78.0 0.1 2.2e-19 69.8 0.1 2.9 1 1 0 1 1 1 1 Aldo/keto reductase family AAA_11 PF13086.6 ETO32726.1 - 0.57 9.9 14.1 0.57 9.9 14.1 1.2 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 ETO32726.1 - 2 7.1 8.7 2.2 6.9 8.7 1.0 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO32726.1 - 5.1 5.8 11.0 5.9 5.6 11.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 ETO32726.1 - 5.5 5.1 14.7 5.6 5.1 14.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF272 PF03312.15 ETO32727.1 - 0.032 14.5 0.5 0.055 13.7 0.5 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF272) MMR_HSR1 PF01926.23 ETO32728.1 - 9.5e-07 28.9 0.1 1.4e-06 28.4 0.1 1.4 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO32728.1 - 0.0064 16.4 0.9 0.011 15.6 0.1 1.8 2 0 0 2 2 2 1 RsgA GTPase AIG1 PF04548.16 ETO32728.1 - 0.031 13.6 0.1 0.044 13.1 0.1 1.3 1 0 0 1 1 1 0 AIG1 family AAA_7 PF12775.7 ETO32728.1 - 0.1 12.1 0.4 0.18 11.3 0.1 1.5 2 0 0 2 2 2 0 P-loop containing dynein motor region Alginate_lyase PF05426.12 ETO32728.1 - 0.13 11.8 0.1 0.13 11.8 0.1 1.6 2 0 0 2 2 2 0 Alginate lyase ABC_tran PF00005.27 ETO32728.1 - 0.14 12.6 0.3 0.32 11.5 0.2 1.6 1 1 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 ETO32728.1 - 0.17 12.3 0.3 0.33 11.3 0.2 1.8 2 1 0 2 2 2 0 AAA ATPase domain MIT PF04212.18 ETO32732.1 - 2.4e-16 59.5 5.4 1.7e-15 56.8 5.4 2.2 1 1 0 1 1 1 1 MIT (microtubule interacting and transport) domain Tim29 PF10171.9 ETO32732.1 - 0.11 11.9 0.3 3.6 7.0 0.0 2.0 2 0 0 2 2 2 0 Translocase of the Inner Mitochondrial membrane 29 WRNPLPNID PF15017.6 ETO32732.1 - 1 10.3 6.2 1.7 9.6 6.2 1.3 1 0 0 1 1 1 0 Putative WW-binding domain and destruction box AAA PF00004.29 ETO32733.1 - 2.2e-36 125.2 0.1 1.2e-34 119.5 0.0 2.6 2 1 0 2 2 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ETO32733.1 - 1.4e-21 76.3 0.1 3.8e-21 74.8 0.1 1.8 1 0 0 1 1 1 1 Vps4 C terminal oligomerisation domain AAA_22 PF13401.6 ETO32733.1 - 3.7e-07 30.5 0.0 9.8e-07 29.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO32733.1 - 1.8e-05 25.2 0.1 0.00021 21.7 0.1 2.3 1 1 0 1 1 1 1 AAA ATPase domain TIP49 PF06068.13 ETO32733.1 - 0.00013 21.3 0.0 0.00034 19.9 0.0 1.7 2 0 0 2 2 2 1 TIP49 P-loop domain IstB_IS21 PF01695.17 ETO32733.1 - 0.0002 21.1 0.0 0.00042 20.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein AAA_5 PF07728.14 ETO32733.1 - 0.00027 21.0 0.0 0.0024 17.9 0.0 2.4 1 1 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_2 PF07724.14 ETO32733.1 - 0.00055 20.1 0.0 0.0012 19.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_18 PF13238.6 ETO32733.1 - 0.00087 19.8 0.0 0.0031 18.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain IBN_N PF03810.19 ETO32733.1 - 0.00092 19.1 0.9 0.0026 17.6 0.9 1.8 1 0 0 1 1 1 1 Importin-beta N-terminal domain RNA_helicase PF00910.22 ETO32733.1 - 0.00096 19.5 0.2 0.0088 16.4 0.0 2.5 2 0 0 2 2 2 1 RNA helicase ATPase_2 PF01637.18 ETO32733.1 - 0.0017 18.3 0.0 0.0047 16.9 0.0 1.8 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea RuvB_N PF05496.12 ETO32733.1 - 0.0023 17.7 0.0 0.011 15.5 0.0 2.0 2 0 0 2 2 2 1 Holliday junction DNA helicase RuvB P-loop domain AAA_33 PF13671.6 ETO32733.1 - 0.0024 18.1 0.0 0.0047 17.1 0.0 1.5 1 0 0 1 1 1 1 AAA domain Mg_chelatase PF01078.21 ETO32733.1 - 0.0032 16.9 0.0 0.0063 15.9 0.0 1.4 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF815 PF05673.13 ETO32733.1 - 0.0057 15.9 0.1 0.014 14.6 0.0 1.6 2 0 0 2 2 2 1 Protein of unknown function (DUF815) TniB PF05621.11 ETO32733.1 - 0.0085 15.5 0.0 0.019 14.4 0.0 1.5 1 0 0 1 1 1 1 Bacterial TniB protein DUF2075 PF09848.9 ETO32733.1 - 0.011 15.0 0.0 0.023 14.0 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Sigma54_activat PF00158.26 ETO32733.1 - 0.017 14.9 0.1 0.049 13.3 0.1 1.8 1 1 0 1 1 1 0 Sigma-54 interaction domain NACHT PF05729.12 ETO32733.1 - 0.02 14.8 0.0 0.067 13.1 0.0 2.0 1 1 0 1 1 1 0 NACHT domain AAA_24 PF13479.6 ETO32733.1 - 0.02 14.6 0.9 0.034 13.9 0.0 1.9 2 1 0 2 2 1 0 AAA domain Torsin PF06309.11 ETO32733.1 - 0.036 14.2 0.0 0.076 13.1 0.0 1.5 1 0 0 1 1 1 0 Torsin Cas_Csm6 PF09659.10 ETO32733.1 - 0.06 12.1 0.4 0.1 11.4 0.4 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csm6) AAA_7 PF12775.7 ETO32733.1 - 0.067 12.7 0.0 0.35 10.3 0.0 2.0 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 ETO32733.1 - 0.07 12.6 0.0 0.14 11.6 0.0 1.4 1 0 0 1 1 1 0 PhoH-like protein AAA_25 PF13481.6 ETO32733.1 - 0.074 12.6 0.0 0.75 9.3 0.0 2.1 2 0 0 2 2 2 0 AAA domain AAA_21 PF13304.6 ETO32733.1 - 0.075 12.8 0.1 28 4.4 0.0 3.2 3 0 0 3 3 3 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_14 PF13173.6 ETO32733.1 - 0.086 12.9 0.0 0.5 10.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ETO32733.1 - 0.097 13.1 0.0 0.25 11.8 0.0 1.8 1 0 0 1 1 1 0 AAA domain Cse1 PF08506.10 ETO32734.1 - 2.7e-05 23.2 0.1 4.8e-05 22.4 0.1 1.3 1 0 0 1 1 1 1 Cse1 DUF4105 PF13387.6 ETO32734.1 - 0.081 12.6 0.1 0.15 11.6 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4105) CAP_GLY PF01302.25 ETO32736.1 - 0.00082 19.3 0.1 0.02 14.9 0.0 2.6 2 0 0 2 2 2 1 CAP-Gly domain PTSIIB_sorb PF03830.15 ETO32736.1 - 0.022 14.9 0.7 0.037 14.3 0.7 1.2 1 0 0 1 1 1 0 PTS system sorbose subfamily IIB component PepSY_TM_like_2 PF16357.5 ETO32736.1 - 0.091 12.7 0.0 0.14 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative PepSY_TM-like ABC_tran PF00005.27 ETO32737.1 - 5.2e-06 27.0 0.0 9.7e-05 22.9 0.0 2.1 2 0 0 2 2 2 1 ABC transporter AAA_5 PF07728.14 ETO32737.1 - 3.5e-05 23.8 0.0 6.4e-05 23.0 0.0 1.4 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO32737.1 - 0.00066 19.2 0.1 0.0012 18.4 0.1 1.6 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO32737.1 - 0.00095 19.6 0.0 0.0024 18.3 0.0 1.7 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RsgA_GTPase PF03193.16 ETO32737.1 - 0.0037 17.2 0.0 0.0053 16.7 0.0 1.4 1 1 0 1 1 1 1 RsgA GTPase AAA_22 PF13401.6 ETO32737.1 - 0.0048 17.2 0.0 0.0094 16.2 0.0 1.6 1 0 0 1 1 1 1 AAA domain DUF4317 PF14199.6 ETO32737.1 - 0.0067 15.6 0.7 0.0098 15.1 0.7 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF4317) ATPase_2 PF01637.18 ETO32737.1 - 0.007 16.3 1.0 0.12 12.3 0.1 2.4 2 1 1 3 3 3 1 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ETO32737.1 - 0.0077 16.3 0.0 0.021 14.9 0.0 1.7 2 0 0 2 2 2 1 AAA domain NACHT PF05729.12 ETO32737.1 - 0.034 14.1 0.0 0.22 11.4 0.0 2.1 2 0 0 2 2 2 0 NACHT domain ATP-synt_ab PF00006.25 ETO32737.1 - 0.051 13.2 0.0 0.077 12.6 0.0 1.3 1 0 0 1 1 1 0 ATP synthase alpha/beta family, nucleotide-binding domain RNA_helicase PF00910.22 ETO32737.1 - 0.069 13.6 0.1 0.14 12.5 0.1 1.8 1 1 0 1 1 1 0 RNA helicase AAA_16 PF13191.6 ETO32737.1 - 0.076 13.4 0.0 0.13 12.6 0.0 1.5 1 1 0 1 1 1 0 AAA ATPase domain TsaE PF02367.17 ETO32737.1 - 0.08 12.9 0.0 0.14 12.2 0.0 1.4 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activat PF00158.26 ETO32737.1 - 0.12 12.0 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Sigma-54 interaction domain Rhodanese PF00581.20 ETO32738.1 - 9.1e-06 26.2 0.2 1.4e-05 25.6 0.2 1.3 1 0 0 1 1 1 1 Rhodanese-like domain zf-CSL PF05207.13 ETO32739.1 - 0.06 13.1 0.0 0.077 12.7 0.0 1.4 1 0 0 1 1 1 0 CSL zinc finger RNA_polI_A34 PF08208.11 ETO32739.1 - 0.44 10.6 16.1 0.58 10.2 16.1 1.2 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 DUF3527 PF12043.8 ETO32739.1 - 6.1 6.3 13.6 9 5.8 13.6 1.2 1 1 0 1 1 1 0 Domain of unknown function (DUF3527) Myotub-related PF06602.14 ETO32742.1 - 3.5e-120 401.2 0.7 4.1e-120 400.9 0.7 1.1 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Y_phosphatase PF00102.27 ETO32742.1 - 4.5e-05 23.1 0.1 0.00017 21.2 0.0 1.9 2 0 0 2 2 2 1 Protein-tyrosine phosphatase DSPc PF00782.20 ETO32742.1 - 7.9e-05 22.5 1.8 9.5e-05 22.2 0.3 1.8 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO32742.1 - 0.0011 19.0 0.1 0.0019 18.2 0.1 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ETO32742.1 - 0.0023 17.5 0.8 0.022 14.4 0.0 2.6 3 0 0 3 3 3 1 Tyrosine phosphatase family NHR2 PF08788.11 ETO32742.1 - 1.6 8.5 9.0 32 4.4 0.1 3.6 2 1 1 3 3 3 0 NHR2 domain like WD40 PF00400.32 ETO32743.1 - 5.4e-22 77.7 12.3 3e-06 27.8 0.0 5.3 5 1 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32743.1 - 2.5e-09 37.3 0.1 0.22 11.9 0.0 4.1 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32743.1 - 5.2e-08 32.0 0.3 0.015 14.0 0.0 3.5 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32743.1 - 8.9e-05 22.0 0.4 0.0087 15.4 0.0 2.8 1 1 2 3 3 3 2 WD40-like domain SH3_13 PF18335.1 ETO32743.1 - 0.077 12.8 0.0 2.1 8.2 0.0 2.4 2 0 0 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain RVT_1 PF00078.27 ETO32744.1 - 6.3e-19 68.4 0.0 1.1e-18 67.6 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) EGF PF00008.27 ETO32745.1 - 0.0014 18.8 6.4 0.0014 18.8 6.4 2.7 4 0 0 4 4 4 1 EGF-like domain hEGF PF12661.7 ETO32745.1 - 0.025 15.2 4.6 0.025 15.2 4.6 3.9 4 0 0 4 4 4 0 Human growth factor-like EGF Ras PF00071.22 ETO32746.1 - 5.1e-12 45.7 0.1 4e-07 29.8 0.1 2.5 2 0 0 2 2 2 2 Ras family PH PF00169.29 ETO32746.1 - 1.1e-09 38.7 0.6 3.6e-09 37.1 0.1 2.2 2 0 0 2 2 2 1 PH domain C2 PF00168.30 ETO32746.1 - 4.4e-08 33.3 0.0 1.4e-07 31.8 0.0 1.9 1 0 0 1 1 1 1 C2 domain PH_11 PF15413.6 ETO32746.1 - 0.00013 22.4 2.1 0.00013 22.4 2.1 3.2 2 1 0 2 2 2 1 Pleckstrin homology domain PH_13 PF16652.5 ETO32746.1 - 0.0076 16.1 0.0 0.027 14.3 0.0 1.9 1 0 0 1 1 1 1 Pleckstrin homology domain Roc PF08477.13 ETO32746.1 - 0.058 13.6 0.2 0.3 11.3 0.0 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase Cyc-maltodext_N PF09087.11 ETO32746.1 - 0.13 12.5 0.6 0.42 10.9 0.6 1.8 1 0 0 1 1 1 0 Cyclomaltodextrinase, N-terminal PS_Dcarbxylase PF02666.15 ETO32747.1 - 3.4e-14 52.9 0.0 5.4e-14 52.2 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylserine decarboxylase Phasin PF05597.11 ETO32748.1 - 0.11 12.5 0.9 0.14 12.2 0.9 1.1 1 0 0 1 1 1 0 Poly(hydroxyalcanoate) granule associated protein (phasin) MGS PF02142.22 ETO32751.1 - 2e-13 50.3 0.0 2.7e-13 49.9 0.0 1.2 1 0 0 1 1 1 1 MGS-like domain SepSecS PF05889.13 ETO32751.1 - 0.00093 18.0 0.0 0.0011 17.7 0.0 1.1 1 0 0 1 1 1 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS GPS PF01825.21 ETO32754.1 - 5.7e-10 39.6 2.7 1e-09 38.8 2.7 1.4 1 0 0 1 1 1 1 GPCR proteolysis site, GPS, motif Focal_AT PF03623.13 ETO32755.1 - 0.079 13.0 9.3 0.039 13.9 6.0 2.0 2 0 0 2 2 2 0 Focal adhesion targeting region Nup54 PF13874.6 ETO32755.1 - 0.21 11.7 16.7 0.23 11.6 6.0 3.1 2 1 1 3 3 3 0 Nucleoporin complex subunit 54 NPV_P10 PF05531.12 ETO32755.1 - 1.1 9.8 7.1 4.2 7.9 1.6 3.0 1 1 1 2 2 2 0 Nucleopolyhedrovirus P10 protein Baculo_PEP_C PF04513.12 ETO32755.1 - 1.5 8.8 10.4 1.6 8.8 4.2 3.3 3 1 0 3 3 3 0 Baculovirus polyhedron envelope protein, PEP, C terminus Pox_Ag35 PF03286.14 ETO32756.1 - 0.022 14.6 8.3 0.038 13.8 8.3 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Zip PF02535.22 ETO32756.1 - 4.9 6.3 4.7 8.1 5.6 4.7 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter SKG6 PF08693.10 ETO32757.1 - 5.9e-08 32.0 1.9 5.9e-08 32.0 1.9 2.2 2 0 0 2 2 2 1 Transmembrane alpha-helix domain GAPT PF11770.8 ETO32757.1 - 0.007 16.2 0.7 0.019 14.8 0.0 2.0 2 0 0 2 2 2 1 GRB2-binding adapter (GAPT) MAP17 PF15807.5 ETO32757.1 - 0.015 15.5 0.0 0.036 14.3 0.0 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 SHR3_chaperone PF08229.11 ETO32757.1 - 0.029 13.4 0.0 0.085 11.8 0.0 1.8 2 0 0 2 2 2 0 ER membrane protein SH3 CD34_antigen PF06365.12 ETO32757.1 - 0.079 12.5 0.0 0.15 11.6 0.0 1.4 1 0 0 1 1 1 0 CD34/Podocalyxin family DUF4448 PF14610.6 ETO32757.1 - 0.13 12.0 0.4 0.28 10.9 0.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4448) MLANA PF14991.6 ETO32757.1 - 0.13 12.5 0.0 0.32 11.3 0.0 1.7 1 0 0 1 1 1 0 Protein melan-A RRM_1 PF00076.22 ETO32758.1 - 1.5e-05 24.7 0.0 5.2e-05 23.0 0.0 1.9 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CHASE7 PF17151.4 ETO32758.1 - 0.16 11.6 5.9 0.79 9.3 2.1 2.2 2 0 0 2 2 2 0 Periplasmic sensor domain WD40 PF00400.32 ETO32759.1 - 1e-55 184.4 20.9 2.2e-09 37.8 0.1 8.3 9 0 0 9 9 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32759.1 - 8.5e-20 70.9 1.0 0.0034 17.6 0.0 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32759.1 - 1.1e-13 50.8 0.1 0.09 11.7 0.0 6.3 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32759.1 - 3e-11 43.2 3.0 0.0045 16.3 0.0 5.0 3 1 2 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO32759.1 - 6e-07 28.5 4.4 0.028 13.1 0.0 4.4 2 2 2 4 4 4 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO32759.1 - 5.1e-05 22.0 0.2 0.0051 15.4 0.0 2.9 1 1 2 3 3 3 1 Cytochrome D1 heme domain DUF727 PF05303.12 ETO32759.1 - 0.00021 21.3 0.4 1 9.5 0.0 4.4 3 1 1 4 4 4 1 Protein of unknown function (DUF727) DUF1797 PF08796.10 ETO32759.1 - 0.0027 17.7 0.0 1.2 9.3 0.0 3.5 3 0 0 3 3 3 1 Protein of unknown function (DUF1797) PD40 PF07676.12 ETO32759.1 - 0.018 15.0 4.7 24 5.0 0.1 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Kelch_1 PF01344.25 ETO32759.1 - 0.033 13.8 5.1 18 5.0 0.0 4.9 5 0 0 5 5 5 0 Kelch motif Kelch_4 PF13418.6 ETO32759.1 - 0.057 13.4 0.2 0.56 10.3 0.1 2.8 3 0 0 3 3 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO32759.1 - 0.069 13.5 5.9 11 6.5 0.0 5.3 7 0 0 7 7 7 0 Kelch motif Kelch_5 PF13854.6 ETO32759.1 - 0.14 12.1 2.8 5 7.2 0.0 3.4 3 0 0 3 3 3 0 Kelch motif Plk4_PB1 PF18190.1 ETO32759.1 - 1.9 8.7 4.8 40 4.4 0.0 4.3 4 1 1 5 5 5 0 Polo-like Kinase 4 Polo Box 1 SRAP PF02586.14 ETO32760.1 - 6.7e-54 182.7 0.2 9.8e-54 182.2 0.2 1.2 1 0 0 1 1 1 1 SOS response associated peptidase (SRAP) Metallophos PF00149.28 ETO32761.1 - 8.9e-05 23.1 0.0 0.00024 21.7 0.0 1.8 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase Cnd1 PF12717.7 ETO32762.1 - 1e-05 25.6 1.1 0.032 14.3 0.2 2.2 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 HEAT PF02985.22 ETO32762.1 - 0.00026 21.0 0.2 0.0052 16.9 0.0 3.0 2 1 0 2 2 2 1 HEAT repeat Spore_III_AB PF09548.10 ETO32762.1 - 0.0028 17.8 0.2 0.0034 17.5 0.2 1.1 1 0 0 1 1 1 1 Stage III sporulation protein AB (spore_III_AB) TIP120 PF08623.10 ETO32762.1 - 0.013 15.3 1.2 0.31 10.8 1.2 2.2 1 1 0 1 1 1 0 TATA-binding protein interacting (TIP20) Condensin2nSMC PF12422.8 ETO32762.1 - 0.013 15.7 0.1 0.031 14.5 0.1 1.6 1 1 0 1 1 1 0 Condensin II non structural maintenance of chromosomes subunit FANCI_S1 PF14675.6 ETO32762.1 - 0.023 14.3 0.5 0.031 13.9 0.5 1.1 1 0 0 1 1 1 0 FANCI solenoid 1 Gcn1_N PF12074.8 ETO32762.1 - 0.043 13.1 0.0 0.05 12.9 0.0 1.0 1 0 0 1 1 1 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DUF1759 PF03564.15 ETO32762.1 - 0.077 12.9 0.2 0.1 12.6 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1759) Peptidase_M3 PF01432.20 ETO32763.1 - 4.6e-38 131.6 0.1 5.1e-38 131.5 0.1 1.0 1 0 0 1 1 1 1 Peptidase family M3 Peptidase_M3 PF01432.20 ETO32764.1 - 1.3e-09 37.9 0.1 1.8e-09 37.4 0.1 1.2 1 0 0 1 1 1 1 Peptidase family M3 DEP PF00610.21 ETO32765.1 - 1.5e-17 63.4 0.0 2.2e-17 62.9 0.0 1.3 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) ETRAMP PF09716.10 ETO32767.1 - 0.19 11.8 3.4 0.58 10.3 3.4 1.8 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Tetraspanin PF00335.20 ETO32769.1 - 0.088 12.5 0.1 0.23 11.1 0.1 1.8 1 0 0 1 1 1 0 Tetraspanin family DUF4834 PF16118.5 ETO32769.1 - 0.81 10.7 0.0 0.81 10.7 0.0 4.9 4 2 0 4 4 4 0 Domain of unknown function (DUF4834) Herpes_US9 PF06072.11 ETO32769.1 - 0.87 9.5 3.1 0.73 9.7 0.5 2.2 2 0 0 2 2 2 0 Alphaherpesvirus tegument protein US9 WD40 PF00400.32 ETO32770.1 - 1.5e-31 107.9 8.7 3.2e-09 37.3 0.2 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32770.1 - 3.5e-12 46.5 0.8 0.0011 19.3 0.0 3.5 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32770.1 - 4.7e-06 26.2 1.3 6.2e-05 22.5 1.3 2.0 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO32770.1 - 7.6e-05 21.6 1.1 0.18 10.4 0.3 2.4 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO32770.1 - 0.00014 20.9 2.7 0.64 8.9 0.1 3.7 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO32770.1 - 0.00074 18.4 1.5 0.16 10.7 0.4 2.4 1 1 1 2 2 2 2 Nup133 N terminal like TFIIIC_delta PF12657.7 ETO32770.1 - 0.034 14.1 0.6 0.11 12.5 0.0 1.8 1 1 0 2 2 2 0 Transcription factor IIIC subunit delta N-term Cytochrom_D1 PF02239.16 ETO32770.1 - 0.037 12.6 0.1 0.45 9.0 0.0 1.9 1 1 1 2 2 2 0 Cytochrome D1 heme domain PQQ PF01011.21 ETO32770.1 - 0.039 13.9 0.0 15 5.7 0.0 3.1 3 0 0 3 3 3 0 PQQ enzyme repeat MucBP_2 PF17965.1 ETO32770.1 - 0.16 12.6 0.0 1.5 9.4 0.0 2.3 1 1 1 2 2 2 0 Mucin binding domain Ricin_B_lectin PF00652.22 ETO32770.1 - 0.2 11.9 4.3 0.44 10.8 1.4 2.2 1 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain Coat_X PF07552.11 ETO32770.1 - 3.2 7.7 5.3 5.9 6.8 0.1 3.1 4 0 0 4 4 4 0 Spore Coat Protein X and V domain HJURP_mid PF12346.8 ETO32771.1 - 0.011 16.1 4.0 0.013 15.9 4.0 1.2 1 0 0 1 1 1 0 Holliday junction recognition protein-associated repeat DUF5095 PF17016.5 ETO32771.1 - 0.13 12.0 7.5 0.16 11.6 7.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF5095) DUF2868 PF11067.8 ETO32771.1 - 0.51 9.8 2.0 0.52 9.8 2.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2868) LIM_bind PF01803.16 ETO32771.1 - 2.1 7.8 7.1 2.8 7.4 7.1 1.1 1 0 0 1 1 1 0 LIM-domain binding protein Tim54 PF11711.8 ETO32771.1 - 2.6 6.7 10.7 2.6 6.7 10.7 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Trypan_PARP PF05887.11 ETO32771.1 - 6.8 6.7 12.9 9.4 6.2 12.9 1.1 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) Peptidase_M24 PF00557.24 ETO32772.1 - 1.8e-40 138.9 0.1 2.2e-40 138.6 0.1 1.1 1 0 0 1 1 1 1 Metallopeptidase family M24 DivIC PF04977.15 ETO32773.1 - 0.0055 16.4 0.6 0.0055 16.4 0.6 2.8 1 1 1 2 2 2 1 Septum formation initiator TIR PF01582.20 ETO32773.1 - 0.017 14.9 0.7 0.027 14.3 0.7 1.3 1 0 0 1 1 1 0 TIR domain Tropomyosin PF00261.20 ETO32773.1 - 0.021 14.2 11.6 0.029 13.8 11.6 1.1 1 0 0 1 1 1 0 Tropomyosin DUF1206 PF06724.11 ETO32773.1 - 0.03 14.4 2.3 2.1 8.5 0.1 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF1206) DUF4618 PF15397.6 ETO32773.1 - 0.041 13.3 8.8 0.72 9.2 9.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4618) DUF5388 PF17363.2 ETO32773.1 - 0.093 12.9 3.5 3.7 7.8 0.4 2.9 2 1 1 3 3 3 0 Family of unknown function (DUF5388) tRNA_synt_1c_R2 PF04557.15 ETO32773.1 - 0.12 13.4 1.3 0.17 12.9 0.5 1.7 1 1 1 2 2 2 0 Glutaminyl-tRNA synthetase, non-specific RNA binding region part 2 TMF_TATA_bd PF12325.8 ETO32773.1 - 0.14 12.4 12.0 0.052 13.8 8.9 1.7 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Spc7 PF08317.11 ETO32773.1 - 0.33 9.8 12.3 0.53 9.1 12.2 1.4 1 1 0 1 1 1 0 Spc7 kinetochore protein DUF2203 PF09969.9 ETO32773.1 - 1 10.1 6.7 0.57 10.9 2.7 2.1 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) H-kinase_dim PF02895.14 ETO32773.1 - 2 8.9 5.7 3.2e+02 1.8 5.7 2.8 1 1 0 1 1 1 0 Signal transducing histidine kinase, homodimeric domain TMPIT PF07851.13 ETO32773.1 - 3.8 6.7 6.3 5.4 6.2 6.3 1.3 1 0 0 1 1 1 0 TMPIT-like protein ZapB PF06005.12 ETO32773.1 - 7.5 7.1 18.7 0.24 11.9 3.8 3.0 1 1 2 3 3 3 0 Cell division protein ZapB DUF2870 PF11069.8 ETO32774.1 - 0.18 12.2 1.4 0.35 11.3 1.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2870) Orf78 PF06024.12 ETO32775.1 - 0.0075 16.6 5.0 0.018 15.3 5.0 1.6 1 0 0 1 1 1 1 Orf78 (ac78) SARAF PF06682.12 ETO32775.1 - 0.019 14.6 0.0 0.031 13.9 0.0 1.2 1 0 0 1 1 1 0 SOCE-associated regulatory factor of calcium homoeostasis TMEM154 PF15102.6 ETO32775.1 - 0.02 14.8 3.2 0.037 14.0 3.2 1.4 1 0 0 1 1 1 0 TMEM154 protein family MFAP1 PF06991.11 ETO32776.1 - 0.023 14.6 3.4 0.024 14.5 3.4 1.1 1 0 0 1 1 1 0 Microfibril-associated/Pre-mRNA processing Med14 PF08638.11 ETO32777.1 - 2.1e-14 53.4 0.1 3.9e-11 42.7 0.0 2.2 2 0 0 2 2 2 2 Mediator complex subunit MED14 Coilin_N PF15862.5 ETO32777.1 - 0.00017 21.4 2.3 0.00017 21.4 2.3 2.8 3 0 0 3 3 3 1 Coilin N-terminus Peptidase_S49_N PF08496.10 ETO32777.1 - 0.077 13.1 8.8 0.24 11.4 6.7 2.2 2 0 0 2 2 2 0 Peptidase family S49 N-terminal BPL_N PF09825.9 ETO32777.1 - 0.16 11.0 0.0 0.16 11.0 0.0 2.1 2 0 0 2 2 2 0 Biotin-protein ligase, N terminal DUF4834 PF16118.5 ETO32777.1 - 0.32 12.0 7.2 0.58 11.2 5.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) RNA_pol_Rpc4 PF05132.14 ETO32777.1 - 0.37 11.2 7.1 0.04 14.3 2.9 1.6 2 0 0 2 2 2 0 RNA polymerase III RPC4 Connexin PF00029.19 ETO32777.1 - 0.53 10.0 6.2 1.1 9.0 6.0 1.7 2 0 0 2 2 2 0 Connexin Presenilin PF01080.17 ETO32777.1 - 1.1 7.9 8.5 1.9 7.1 8.5 1.4 1 0 0 1 1 1 0 Presenilin Neur_chan_memb PF02932.16 ETO32777.1 - 2 8.4 4.4 2.8 8.0 4.4 1.3 1 1 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Insulin_TMD PF17870.1 ETO32778.1 - 4.5 7.4 5.9 6.3 6.9 4.5 2.1 1 1 0 1 1 1 0 Insulin receptor trans-membrane segment GCP_N_terminal PF17681.1 ETO32779.1 - 1.3e-35 123.6 0.5 2.3e-34 119.4 0.5 2.1 1 1 0 1 1 1 1 Gamma tubulin complex component N-terminal SKA1 PF07160.12 ETO32779.1 - 0.017 15.0 1.1 0.027 14.3 1.1 1.4 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 DUF3586 PF12131.8 ETO32779.1 - 3.8 7.8 7.0 8.1 6.7 0.8 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3586) PK_C PF02887.16 ETO32782.1 - 4.6e-23 81.7 1.1 9.6e-23 80.6 1.1 1.6 1 0 0 1 1 1 1 Pyruvate kinase, alpha/beta domain SR-25 PF10500.9 ETO32782.1 - 0.0019 17.8 11.6 0.0019 17.8 11.6 2.5 2 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein RAB3GAP2_C PF14656.6 ETO32782.1 - 0.033 12.4 5.0 0.067 11.4 5.0 1.4 1 0 0 1 1 1 0 Rab3 GTPase-activating protein regulatory subunit C-terminus Sigma_reg_N PF13800.6 ETO32782.1 - 0.086 13.1 0.6 0.28 11.5 0.6 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal USP19_linker PF16602.5 ETO32782.1 - 0.38 11.3 4.5 0.28 11.8 1.2 2.4 3 0 0 3 3 3 0 Linker region of USP19 deubiquitinase Conotoxin PF02950.17 ETO32782.1 - 2.2 9.3 12.8 6.5 7.9 0.0 3.6 3 0 0 3 3 3 0 Conotoxin DUF4820 PF16091.5 ETO32782.1 - 2.9 7.2 14.3 0.16 11.3 8.5 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4820) Cation_ATPase PF13246.6 ETO32783.1 - 4.1e-09 36.4 1.0 1.2e-08 34.9 1.0 2.0 1 1 0 1 1 1 1 Cation transport ATPase (P-type) CDC45 PF02724.14 ETO32783.1 - 7.5e-05 21.2 9.0 7.5e-05 21.2 9.0 2.5 1 1 1 2 2 2 1 CDC45-like protein BUD22 PF09073.10 ETO32783.1 - 0.00042 19.8 30.1 0.0007 19.0 30.1 1.4 1 0 0 1 1 1 1 BUD22 Nop14 PF04147.12 ETO32783.1 - 0.32 9.2 44.6 0.52 8.5 44.6 1.3 1 0 0 1 1 1 0 Nop14-like family MRAP PF15183.6 ETO32783.1 - 0.35 10.8 2.7 6.8 6.7 0.2 2.7 2 0 0 2 2 2 0 Melanocortin-2 receptor accessory protein family Erv26 PF04148.13 ETO32783.1 - 5.2 6.8 9.9 0.05 13.4 1.5 1.9 2 0 0 2 2 2 0 Transmembrane adaptor Erv26 MbeD_MobD PF04899.12 ETO32784.1 - 0.0055 16.8 0.7 0.35 11.0 0.1 2.5 2 0 0 2 2 2 1 MbeD/MobD like GrpE PF01025.19 ETO32784.1 - 0.73 9.5 9.3 3.3 7.4 0.4 2.3 2 0 0 2 2 2 0 GrpE Uso1_p115_C PF04871.13 ETO32784.1 - 2.3 8.6 5.1 8.7 6.7 1.8 2.1 1 1 1 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region DUF2157 PF09925.9 ETO32785.1 - 6.8e-05 22.7 0.1 8.8e-05 22.3 0.1 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2157) DUF373 PF04123.13 ETO32785.1 - 0.0054 16.2 1.6 0.0071 15.8 1.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF373) MgtE PF01769.16 ETO32785.1 - 0.021 15.2 2.5 0.25 11.7 0.6 2.1 2 0 0 2 2 2 0 Divalent cation transporter PMP22_Claudin PF00822.20 ETO32785.1 - 0.033 14.0 0.5 0.033 14.0 0.5 1.8 1 1 1 2 2 2 0 PMP-22/EMP/MP20/Claudin family DUF4293 PF14126.6 ETO32785.1 - 0.068 13.4 3.6 1.2 9.4 0.8 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) Phage_holin_3_6 PF07332.11 ETO32785.1 - 0.2 11.7 2.6 0.16 12.1 0.9 1.6 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III DUF3784 PF12650.7 ETO32785.1 - 0.38 11.0 12.6 0.055 13.7 1.9 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3784) DUF2207 PF09972.9 ETO32785.1 - 0.4 9.4 4.4 0.65 8.7 4.4 1.6 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) MerC PF03203.14 ETO32785.1 - 1.6 9.2 8.4 0.38 11.2 0.5 2.1 2 0 0 2 2 2 0 MerC mercury resistance protein DUF3671 PF12420.8 ETO32785.1 - 4 7.5 6.9 4.5 7.4 0.3 2.3 1 1 1 2 2 2 0 Protein of unknown function DUF4064 PF13273.6 ETO32785.1 - 5.3 7.4 11.2 4.6 7.6 7.0 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF4064) SDP_N PF12278.8 ETO32786.1 - 9.8 6.3 12.6 2.6 8.2 1.5 3.1 2 0 0 2 2 2 0 Sex determination protein N terminal RCC1 PF00415.18 ETO32787.1 - 6e-18 65.2 8.9 0.00022 21.8 0.0 5.3 5 0 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO32787.1 - 1.2e-12 47.2 14.7 7.1e-07 28.9 1.1 5.3 5 0 0 5 5 5 2 Regulator of chromosome condensation (RCC1) repeat WD40 PF00400.32 ETO32788.1 - 0.0043 17.9 0.5 0.0043 17.9 0.5 2.2 2 1 0 2 2 2 1 WD domain, G-beta repeat PUD PF03714.14 ETO32788.1 - 0.024 15.5 0.2 2.2 9.2 0.1 2.0 1 1 1 2 2 2 0 Bacterial pullanase-associated domain Peptidase_C14 PF00656.22 ETO32789.1 - 1.5e-09 38.1 0.3 2.7e-09 37.4 0.3 1.4 1 1 0 1 1 1 1 Caspase domain WD40 PF00400.32 ETO32790.1 - 9.9e-33 111.7 21.1 1.9e-07 31.7 0.1 6.8 6 2 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32790.1 - 2.1e-09 37.5 0.6 0.042 14.2 0.0 4.6 3 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32790.1 - 2.2e-09 36.5 5.2 0.2 10.3 0.0 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 DUF3915 PF13054.6 ETO32790.1 - 0.027 14.4 1.2 0.14 12.1 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) CUE PF02845.16 ETO32793.1 - 4.2e-09 35.9 0.4 4.4e-06 26.3 0.1 2.8 2 0 0 2 2 2 2 CUE domain DUF515 PF04415.12 ETO32793.1 - 1.3 7.3 8.8 3.5 5.9 6.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF515) SPOC PF07744.13 ETO32794.1 - 9.9e-05 22.3 0.1 0.00014 21.8 0.1 1.2 1 0 0 1 1 1 1 SPOC domain Atrophin-1 PF03154.15 ETO32794.1 - 0.004 15.5 0.9 0.0046 15.3 0.9 1.0 1 0 0 1 1 1 1 Atrophin-1 family Tim54 PF11711.8 ETO32794.1 - 0.0083 15.0 1.2 0.0089 14.9 1.2 1.1 1 0 0 1 1 1 1 Inner membrane protein import complex subunit Tim54 DUF3915 PF13054.6 ETO32794.1 - 0.5 10.4 2.3 0.76 9.8 2.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) SR-25 PF10500.9 ETO32794.1 - 0.6 9.7 11.1 0.96 9.0 11.1 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein OAD_gamma PF04277.13 ETO32794.1 - 0.64 10.6 4.8 1.1 9.8 4.8 1.4 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain DUF3464 PF11947.8 ETO32794.1 - 2.8 7.7 5.1 3.9 7.2 5.1 1.2 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 Kelch_6 PF13964.6 ETO32795.1 - 1.4e-05 25.2 3.4 0.013 15.8 0.1 3.4 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO32795.1 - 2e-05 24.4 3.8 0.052 13.5 1.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO32795.1 - 2.6e-05 23.7 2.9 0.14 11.8 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO32795.1 - 0.00035 20.8 0.0 0.91 9.9 0.0 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO32795.1 - 0.0086 16.0 3.8 0.28 11.2 0.0 3.6 4 0 0 4 4 4 1 Kelch motif PSP94 PF05825.11 ETO32795.1 - 0.033 14.7 4.9 1.1 9.8 0.3 2.8 2 0 0 2 2 2 0 Beta-microseminoprotein (PSP-94) Kelch_4 PF13418.6 ETO32795.1 - 0.11 12.5 0.5 32 4.6 0.4 3.1 2 1 0 2 2 2 0 Galactose oxidase, central domain Tmemb_cc2 PF10267.9 ETO32795.1 - 0.14 11.3 4.8 0.2 10.8 4.8 1.1 1 0 0 1 1 1 0 Predicted transmembrane and coiled-coil 2 protein Bcr-Abl_Oligo PF09036.10 ETO32795.1 - 0.15 12.1 1.5 0.32 11.0 1.5 1.5 1 0 0 1 1 1 0 Bcr-Abl oncoprotein oligomerisation domain IMD PF08397.11 ETO32795.1 - 2.8 7.3 7.4 4.7 6.5 7.4 1.3 1 0 0 1 1 1 0 IRSp53/MIM homology domain WD40 PF00400.32 ETO32796.1 - 4.7e-58 191.8 14.1 1.1e-08 35.6 0.0 7.6 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32796.1 - 4.5e-14 52.5 2.7 8.2e-05 22.8 0.0 5.5 1 1 4 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32796.1 - 1e-08 34.5 0.1 0.068 12.1 0.0 5.5 2 2 4 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32796.1 - 5.1e-06 26.0 3.8 0.00096 18.6 0.0 3.3 2 1 2 4 4 4 2 WD40-like domain eIF2A PF08662.11 ETO32796.1 - 4.6e-05 23.4 0.4 0.13 12.1 0.0 3.3 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO32796.1 - 0.0049 15.6 5.2 1.9 7.1 0.1 4.3 2 1 2 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO32796.1 - 0.011 15.6 2.8 22 5.1 0.0 4.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO32796.1 - 0.012 14.6 3.4 0.61 9.0 0.0 3.8 2 1 1 4 4 4 0 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 ETO32796.1 - 0.012 15.2 0.2 0.3 10.6 0.2 2.6 2 1 0 2 2 2 0 PQQ-like domain Lant_dehydr_N PF04738.13 ETO32796.1 - 0.02 13.0 0.0 0.026 12.6 0.0 1.1 1 0 0 1 1 1 0 Lantibiotic dehydratase, N terminus Nbas_N PF15492.6 ETO32796.1 - 0.038 13.3 0.7 1.1 8.5 0.1 2.5 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal WD40 PF00400.32 ETO32797.1 - 3.2e-47 157.5 14.1 4e-10 40.1 0.0 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32797.1 - 7.7e-18 64.6 1.2 0.0018 18.6 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32797.1 - 1.4e-13 50.6 2.2 0.062 12.3 0.0 6.1 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32797.1 - 1.1e-05 24.3 1.2 0.13 10.9 0.1 3.9 1 1 1 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32797.1 - 2.4e-05 23.8 5.6 0.046 13.0 0.0 3.0 2 1 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO32797.1 - 9.2e-05 21.1 0.0 0.021 13.4 0.0 3.0 1 1 2 3 3 3 3 Cytochrome D1 heme domain DUF4988 PF16378.5 ETO32797.1 - 0.048 13.3 0.1 0.17 11.5 0.1 2.0 1 1 0 1 1 1 0 Domain of unknown function PD40 PF07676.12 ETO32797.1 - 0.098 12.6 6.5 24 5.0 0.1 4.7 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO32797.1 - 1.3 8.8 6.7 5 6.9 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Kelch_6 PF13964.6 ETO32798.1 - 0.11 12.8 4.5 1.6 9.1 0.1 4.2 5 0 0 5 5 5 0 Kelch motif Agouti PF05039.12 ETO32799.1 - 1.8 9.3 6.7 1.9 9.3 6.7 1.1 1 0 0 1 1 1 0 Agouti protein AP3D1 PF06375.11 ETO32799.1 - 2.7 8.2 16.9 2.7 8.2 16.9 1.0 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 AAA PF00004.29 ETO32802.1 - 1.8e-09 38.1 6.4 0.0038 17.7 6.2 3.2 2 1 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO32802.1 - 7.3e-09 36.0 0.1 0.0024 18.1 0.0 2.6 2 0 0 2 2 2 2 AAA domain AAA_5 PF07728.14 ETO32802.1 - 3.5e-08 33.6 1.6 0.0037 17.3 0.8 3.7 3 1 0 3 3 2 2 AAA domain (dynein-related subfamily) AAA_7 PF12775.7 ETO32802.1 - 1.6e-07 31.0 0.0 0.00067 19.2 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region ATPase_2 PF01637.18 ETO32802.1 - 1.8e-07 31.4 8.3 3.3e-06 27.2 1.5 3.1 3 0 0 3 3 3 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO32802.1 - 3e-06 27.7 0.1 0.00047 20.6 0.0 2.9 2 1 1 3 3 3 1 AAA ATPase domain ABC_tran PF00005.27 ETO32802.1 - 5.2e-06 27.0 1.7 1.7e-05 25.3 0.2 2.6 3 0 0 3 3 2 1 ABC transporter RsgA_GTPase PF03193.16 ETO32802.1 - 2.3e-05 24.4 0.2 2.3e-05 24.4 0.2 2.8 4 0 0 4 4 2 1 RsgA GTPase AAA_8 PF12780.7 ETO32802.1 - 0.00011 21.6 1.2 0.00047 19.6 1.2 2.1 1 1 0 1 1 1 1 P-loop containing dynein motor region D4 AAA_2 PF07724.14 ETO32802.1 - 0.00028 21.0 1.0 0.0096 16.1 0.8 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ETO32802.1 - 0.00072 18.8 0.0 0.0024 17.1 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF815) PduV-EutP PF10662.9 ETO32802.1 - 0.0016 18.2 0.1 0.023 14.4 0.1 2.3 2 0 0 2 2 2 1 Ethanolamine utilisation - propanediol utilisation MCM PF00493.23 ETO32802.1 - 0.0027 16.8 0.3 0.71 8.9 0.1 2.9 3 0 0 3 3 3 1 MCM P-loop domain AAA_14 PF13173.6 ETO32802.1 - 0.0054 16.8 9.5 6.9 6.7 4.0 4.3 4 1 0 4 4 2 0 AAA domain IstB_IS21 PF01695.17 ETO32802.1 - 0.0084 15.9 0.2 1.2 8.8 0.0 3.2 2 1 0 2 2 2 1 IstB-like ATP binding protein Mg_chelatase PF01078.21 ETO32802.1 - 0.0084 15.5 0.5 3 7.2 0.0 3.4 4 0 0 4 4 3 1 Magnesium chelatase, subunit ChlI CobA_CobO_BtuR PF02572.15 ETO32802.1 - 0.0092 16.2 1.5 0.31 11.3 0.8 2.6 2 0 0 2 2 2 1 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP AAA_24 PF13479.6 ETO32802.1 - 0.012 15.4 1.6 0.02 14.6 0.3 2.2 2 0 0 2 2 1 0 AAA domain AAA_18 PF13238.6 ETO32802.1 - 0.018 15.6 0.4 0.089 13.3 0.5 2.2 2 0 0 2 2 1 0 AAA domain Sigma54_activat PF00158.26 ETO32802.1 - 0.019 14.6 0.1 0.83 9.3 0.0 3.2 4 0 0 4 4 3 0 Sigma-54 interaction domain AAA_28 PF13521.6 ETO32802.1 - 0.02 15.1 3.6 0.37 11.0 2.9 3.0 2 1 0 2 2 2 0 AAA domain Viral_helicase1 PF01443.18 ETO32802.1 - 0.021 14.6 0.2 1.3 8.8 0.1 2.6 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase RNA_helicase PF00910.22 ETO32802.1 - 0.04 14.3 0.0 1.4 9.4 0.0 2.9 2 0 0 2 2 2 0 RNA helicase AAA_3 PF07726.11 ETO32802.1 - 0.05 13.5 0.0 5.9 6.8 0.0 3.4 3 1 0 3 3 3 0 ATPase family associated with various cellular activities (AAA) Imm30 PF15565.6 ETO32802.1 - 0.054 13.6 4.3 3.8 7.6 0.2 3.1 3 0 0 3 3 2 0 Immunity protein 30 NACHT PF05729.12 ETO32802.1 - 0.057 13.3 0.1 0.41 10.6 0.1 2.3 2 0 0 2 2 2 0 NACHT domain AAA_30 PF13604.6 ETO32802.1 - 0.066 12.9 0.0 15 5.3 0.0 2.7 2 1 0 2 2 2 0 AAA domain TsaE PF02367.17 ETO32802.1 - 0.072 13.1 0.0 0.072 13.1 0.0 2.9 4 0 0 4 4 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Sigma54_activ_2 PF14532.6 ETO32802.1 - 0.072 13.2 0.0 1.5 8.9 0.0 2.5 2 0 0 2 2 2 0 Sigma-54 interaction domain DUF2252 PF10009.9 ETO32802.1 - 0.084 11.9 0.1 0.15 11.1 0.1 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2252) Rad17 PF03215.15 ETO32802.1 - 0.11 12.3 0.3 0.11 12.3 0.3 3.2 3 1 0 4 4 4 0 Rad17 P-loop domain Ras PF00071.22 ETO32802.1 - 0.13 11.8 1.6 4.2 6.9 0.1 2.8 2 0 0 2 2 2 0 Ras family AAA_25 PF13481.6 ETO32802.1 - 0.18 11.4 0.0 4.6 6.8 0.0 2.7 3 0 0 3 3 3 0 AAA domain AAA_19 PF13245.6 ETO32802.1 - 0.35 11.2 6.9 3.4 8.0 2.3 3.4 2 2 0 2 2 2 0 AAA domain Sec62 PF03839.16 ETO32802.1 - 1.6 8.2 9.7 2 7.9 1.9 2.4 2 0 0 2 2 2 0 Translocation protein Sec62 ResIII PF04851.15 ETO32802.1 - 4.8 7.1 11.8 2.1 8.3 7.1 2.7 1 1 1 2 2 2 0 Type III restriction enzyme, res subunit Colicin PF01024.19 ETO32802.1 - 6.5 6.6 7.7 50 3.7 5.2 3.0 3 0 0 3 3 3 0 Colicin pore forming domain M16C_assoc PF08367.11 ETO32802.1 - 8.2 5.5 9.7 18 4.3 9.7 1.5 1 0 0 1 1 1 0 Peptidase M16C associated ERG2_Sigma1R PF04622.12 ETO32805.1 - 0.0013 18.1 1.1 0.21 10.9 0.1 2.6 2 0 0 2 2 2 2 ERG2 and Sigma1 receptor like protein Vert_HS_TF PF06546.11 ETO32805.1 - 0.0025 17.5 0.6 0.0025 17.5 0.6 2.5 3 0 0 3 3 3 1 Vertebrate heat shock transcription factor HMG-CoA_red PF00368.18 ETO32805.1 - 0.047 12.7 0.2 0.12 11.4 0.2 1.6 1 0 0 1 1 1 0 Hydroxymethylglutaryl-coenzyme A reductase Orf78 PF06024.12 ETO32805.1 - 0.12 12.7 9.5 0.21 11.9 1.9 3.1 2 1 0 2 2 2 0 Orf78 (ac78) Presenilin PF01080.17 ETO32805.1 - 0.3 9.8 6.4 1.7 7.4 1.3 2.5 2 0 0 2 2 2 0 Presenilin PID_2 PF14719.6 ETO32806.1 - 0.0071 16.2 0.9 0.0071 16.2 0.9 2.1 2 0 0 2 2 2 1 Phosphotyrosine interaction domain (PTB/PID) YjcB PF15940.5 ETO32806.1 - 0.093 12.9 0.5 0.49 10.6 0.0 2.1 2 0 0 2 2 2 0 Family of unknown function FlpD PF02662.16 ETO32806.1 - 0.096 12.7 0.4 0.25 11.3 0.0 1.8 2 0 0 2 2 2 0 Methyl-viologen-reducing hydrogenase, delta subunit OAD_gamma PF04277.13 ETO32806.1 - 0.12 13.0 1.1 0.27 11.8 1.1 1.7 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Kelch_1 PF01344.25 ETO32807.1 - 3.3e-08 33.0 2.3 5e-06 26.0 0.4 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO32807.1 - 6.8e-08 32.5 1.7 0.044 14.1 0.2 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO32807.1 - 6e-07 29.2 2.4 0.014 15.4 0.3 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO32807.1 - 5.2e-05 23.1 7.2 0.0053 16.7 1.6 4.4 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO32807.1 - 9.1e-05 22.6 0.1 0.0014 18.8 0.1 2.9 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO32807.1 - 0.0065 16.4 0.1 0.05 13.6 0.1 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain Mit_KHE1 PF10173.9 ETO32809.1 - 0.031 14.4 0.0 0.041 14.0 0.0 1.2 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Ipi1_N PF12333.8 ETO32810.1 - 0.0053 17.3 3.3 0.013 16.1 0.6 2.3 2 0 0 2 2 2 1 Rix1 complex component involved in 60S ribosome maturation SPX PF03105.19 ETO32810.1 - 0.03 14.3 2.9 0.036 14.0 2.9 1.1 1 0 0 1 1 1 0 SPX domain DUF3446 PF11928.8 ETO32810.1 - 0.053 13.8 13.7 1.8 8.9 0.5 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain Peptidase_S49_N PF08496.10 ETO32811.1 - 0.46 10.5 2.8 0.71 9.9 2.8 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PI3Ka PF00613.20 ETO32812.1 - 2.3e-47 160.8 2.6 4.3e-47 159.9 2.6 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) PI3_PI4_kinase PF00454.27 ETO32812.1 - 6e-40 137.6 2.2 4.6e-38 131.5 0.1 3.0 2 1 0 2 2 2 1 Phosphatidylinositol 3- and 4-kinase PI3K_C2 PF00792.24 ETO32812.1 - 4.3e-11 42.9 0.1 1.2e-10 41.5 0.1 1.9 1 1 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ETO32812.1 - 7.7e-11 42.1 1.3 2.3e-10 40.6 0.0 2.4 2 0 0 2 2 2 1 PI3-kinase family, ras-binding domain DUF4293 PF14126.6 ETO32813.1 - 0.0014 18.9 0.4 0.0018 18.5 0.4 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4293) NEMP PF10225.9 ETO32813.1 - 0.0052 16.5 1.1 0.006 16.3 1.1 1.1 1 0 0 1 1 1 1 NEMP family Got1 PF04178.12 ETO32813.1 - 0.03 14.7 0.4 0.057 13.8 0.4 1.4 1 0 0 1 1 1 0 Got1/Sft2-like family WD40 PF00400.32 ETO32814.1 - 2.2e-56 186.5 18.5 9.5e-09 35.8 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32814.1 - 1e-22 80.2 1.2 0.00089 19.5 0.0 5.8 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32814.1 - 1.1e-12 47.5 0.1 0.015 14.2 0.0 5.3 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32814.1 - 2.1e-11 43.7 0.1 0.0024 17.3 0.0 3.6 2 1 2 4 4 4 4 WD40-like domain eIF2A PF08662.11 ETO32814.1 - 1.1e-09 38.5 0.2 0.00025 21.0 0.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO32814.1 - 3.1e-09 36.1 5.6 0.38 9.3 0.1 6.0 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO32814.1 - 1.2e-06 27.3 0.1 0.00034 19.3 0.0 2.4 1 1 2 3 3 3 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO32814.1 - 5.6e-06 26.0 0.0 0.0043 16.9 0.1 3.7 3 0 0 3 3 3 1 PQQ enzyme repeat DUF5570 PF17731.1 ETO32814.1 - 1.2e-05 25.4 1.9 9.3 6.4 0.0 5.0 2 2 3 5 5 5 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO32814.1 - 0.00051 19.9 2.8 7.9 6.5 0.0 4.2 5 0 0 5 5 4 1 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO32814.1 - 0.00054 20.0 0.2 0.073 13.1 0.0 3.2 2 1 0 3 3 3 1 Family of unknown function (DUF5474) Nucleoporin_N PF08801.11 ETO32814.1 - 0.0012 17.6 5.4 3.1 6.4 0.0 5.3 1 1 4 5 5 5 1 Nup133 N terminal like Nbas_N PF15492.6 ETO32814.1 - 0.0017 17.7 0.3 0.25 10.7 0.1 2.8 1 1 1 2 2 2 1 Neuroblastoma-amplified sequence, N terminal VID27 PF08553.10 ETO32814.1 - 0.0065 15.6 0.1 0.24 10.4 0.0 2.4 2 1 0 3 3 3 1 VID27 C-terminal WD40-like domain Resistin PF06954.11 ETO32814.1 - 0.012 16.1 0.7 21 5.8 0.1 4.0 2 1 2 4 4 4 0 Resistin Phage_CI_repr PF07022.13 ETO32814.1 - 0.031 14.3 0.0 1.1 9.4 0.0 2.5 2 0 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain ArlS_N PF18719.1 ETO32814.1 - 0.065 13.4 0.2 2.5 8.3 0.0 2.9 4 0 0 4 4 3 0 ArlS sensor domain Utp8 PF10395.9 ETO32814.1 - 0.17 10.3 0.0 1.6 7.1 0.0 2.2 1 1 0 1 1 1 0 Utp8 family DUF4999 PF16390.5 ETO32814.1 - 1 9.6 3.1 1.2e+02 3.0 0.0 4.3 5 0 0 5 5 4 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO32814.1 - 3.7 7.3 8.8 25 4.7 0.2 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Exostosin PF03016.15 ETO32816.1 - 7.9e-06 25.3 0.0 2.9e-05 23.4 0.0 1.8 1 1 0 2 2 2 1 Exostosin family Kelch_6 PF13964.6 ETO32817.1 - 2e-05 24.7 9.4 0.21 11.9 0.2 4.8 6 0 0 6 6 6 2 Kelch motif Kelch_2 PF07646.15 ETO32817.1 - 0.0052 16.7 5.1 15 5.8 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO32817.1 - 0.026 14.1 4.0 0.37 10.4 0.0 3.8 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO32817.1 - 0.042 13.9 6.8 1.5 8.9 0.0 4.3 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO32818.1 - 7.7e-52 172.1 13.4 1.5e-09 38.3 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32818.1 - 1.9e-23 82.6 3.3 3.3e-06 27.3 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32818.1 - 4.7e-19 68.8 3.9 1e-05 25.0 0.0 3.1 1 1 2 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO32818.1 - 4.5e-16 58.7 1.6 0.00039 19.5 0.0 5.2 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO32818.1 - 2.4e-09 36.4 0.3 0.34 9.5 0.0 5.1 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO32818.1 - 3.5e-07 29.3 6.8 0.085 11.6 0.5 4.6 1 1 4 5 5 5 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO32818.1 - 1.7e-05 23.6 0.2 0.01 14.4 0.1 2.4 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO32818.1 - 0.00038 19.9 1.5 0.17 11.2 0.1 3.1 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO32818.1 - 0.0012 18.8 4.2 1.1 9.3 0.0 4.8 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO32818.1 - 0.0027 17.4 2.5 1.8 8.3 0.2 4.1 3 0 0 3 3 3 1 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO32818.1 - 0.0088 15.9 0.0 7.5 6.7 0.0 4.4 5 0 0 5 5 5 1 PQQ enzyme repeat Utp8 PF10395.9 ETO32818.1 - 0.024 13.1 0.1 0.12 10.9 0.0 1.9 1 1 0 1 1 1 0 Utp8 family Med21 PF11221.8 ETO32822.1 - 0.0025 18.1 2.4 0.0025 18.1 2.4 1.8 2 0 0 2 2 2 1 Subunit 21 of Mediator complex ETRAMP PF09716.10 ETO32822.1 - 8 6.6 16.2 4.4 7.4 6.0 2.9 2 1 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO32823.1 - 3.1e-08 34.1 0.3 4.7e-07 30.4 0.1 3.0 2 0 0 2 2 2 1 WD domain, G-beta repeat Kelch_6 PF13964.6 ETO32823.1 - 1.9e-05 24.8 3.9 0.12 12.7 0.3 4.4 3 2 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO32823.1 - 3.3e-05 23.4 0.3 0.32 10.6 0.1 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO32823.1 - 0.00049 20.1 0.0 0.17 11.9 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO32823.1 - 0.00079 19.4 1.7 0.68 10.0 0.3 3.9 4 0 0 4 4 4 1 Kelch motif ANAPC4_WD40 PF12894.7 ETO32823.1 - 0.0017 18.6 0.1 0.053 13.8 0.0 2.8 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Kelch_2 PF07646.15 ETO32823.1 - 0.0019 18.1 2.3 4.1 7.5 0.0 4.4 4 1 0 4 4 4 2 Kelch motif PCMT PF01135.19 ETO32826.1 - 6.6e-29 101.2 4.0 2.3e-20 73.2 0.0 3.1 2 1 0 2 2 2 2 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) TMEM71 PF15121.6 ETO32826.1 - 0.026 14.2 0.0 0.053 13.2 0.0 1.5 1 0 0 1 1 1 0 TMEM71 protein family Fer4_22 PF17179.4 ETO32827.1 - 0.14 13.0 0.1 0.51 11.2 0.0 1.8 1 1 1 2 2 2 0 4Fe-4S dicluster domain zf-C2H2_4 PF13894.6 ETO32828.1 - 0.00047 20.8 0.5 0.0033 18.1 0.5 2.6 1 0 0 1 1 1 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO32828.1 - 0.00089 19.6 0.4 0.0039 17.6 0.4 2.2 1 0 0 1 1 1 1 Zinc finger, C2H2 type zf-H2C2_2 PF13465.6 ETO32828.1 - 0.15 12.6 0.3 0.15 12.6 0.3 2.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-Di19 PF05605.12 ETO32828.1 - 1 9.7 5.3 0.29 11.4 1.0 2.3 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding DUF2981 PF11200.8 ETO32828.1 - 7.2 6.3 19.7 1 9.0 4.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2981) DnaJ PF00226.31 ETO32829.1 - 6.4e-21 74.2 4.3 4.4e-14 52.4 0.3 2.6 2 0 0 2 2 2 2 DnaJ domain DnaJ_C PF01556.18 ETO32829.1 - 9e-16 58.3 0.0 1.1e-14 54.8 0.0 2.4 1 1 0 1 1 1 1 DnaJ C terminal domain DnaJ_CXXCXGXG PF00684.19 ETO32829.1 - 5.8e-11 42.6 20.1 1.1e-10 41.7 20.1 1.5 1 0 0 1 1 1 1 DnaJ central domain 7TM_GPCR_Srh PF10318.9 ETO32829.1 - 0.0096 15.0 6.4 0.015 14.3 6.4 1.2 1 0 0 1 1 1 1 Serpentine type 7TM GPCR chemoreceptor Srh ETRAMP PF09716.10 ETO32829.1 - 0.17 12.0 11.0 0.54 10.4 0.7 3.3 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Anti-TRAP PF15777.5 ETO32829.1 - 0.23 11.5 16.0 0.15 12.0 3.8 2.5 1 1 1 2 2 2 0 Tryptophan RNA-binding attenuator protein inhibitory protein GWT1 PF06423.12 ETO32829.1 - 1.3 9.1 6.1 3.3 7.8 5.2 2.1 1 1 0 1 1 1 0 GWT1 HypA PF01155.19 ETO32829.1 - 3.1 7.8 12.3 2.1 8.4 2.9 2.6 1 1 1 2 2 2 0 Hydrogenase/urease nickel incorporation, metallochaperone, hypA Rhodanese PF00581.20 ETO32830.1 - 6.5e-14 52.3 1.7 9.8e-09 35.7 0.0 2.2 2 0 0 2 2 2 2 Rhodanese-like domain DUF2917 PF11142.8 ETO32830.1 - 0.1 12.0 0.0 0.17 11.3 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2917) Peptidase_A8 PF01252.18 ETO32831.1 - 0.011 15.9 6.0 0.054 13.7 1.8 2.4 1 1 0 2 2 2 0 Signal peptidase (SPase) II Striatin PF08232.12 ETO32832.1 - 2.6 8.6 15.5 1.7 9.2 0.4 3.4 3 0 0 3 3 3 0 Striatin family Presenilin PF01080.17 ETO32832.1 - 8 5.1 13.1 2.8 6.6 4.4 2.4 2 0 0 2 2 2 0 Presenilin V_ATPase_I PF01496.19 ETO32834.1 - 2.2e-11 42.5 0.4 2.6e-11 42.2 0.2 1.2 1 1 0 1 1 1 1 V-type ATPase 116kDa subunit family Aminopep PF10023.9 ETO32834.1 - 0.029 13.8 0.0 0.033 13.6 0.0 1.1 1 0 0 1 1 1 0 Putative aminopeptidase Filo_VP35 PF02097.15 ETO32834.1 - 0.041 12.9 0.0 0.047 12.8 0.0 1.1 1 0 0 1 1 1 0 Filoviridae VP35 FAD_binding_9 PF08021.11 ETO32834.1 - 0.12 12.5 0.0 0.22 11.7 0.0 1.4 1 1 0 1 1 1 0 Siderophore-interacting FAD-binding domain DUF3302 PF11742.8 ETO32834.1 - 0.2 11.8 0.0 0.29 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3302) ADH_zinc_N_2 PF13602.6 ETO32835.1 - 0.00035 21.6 0.0 0.0072 17.4 0.0 2.2 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_N_2 PF16884.5 ETO32835.1 - 0.0029 17.5 0.0 0.0053 16.6 0.0 1.5 1 0 0 1 1 1 1 N-terminal domain of oxidoreductase RGS PF00615.19 ETO32836.1 - 3.6e-08 33.7 2.2 3.6e-08 33.7 2.2 2.1 2 0 0 2 2 2 1 Regulator of G protein signaling domain RhoGEF PF00621.20 ETO32838.1 - 7.3e-21 75.2 0.0 1.3e-20 74.4 0.0 1.4 1 0 0 1 1 1 1 RhoGEF domain BUD22 PF09073.10 ETO32839.1 - 0.86 8.9 32.6 1.2 8.3 32.6 1.3 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO32840.1 - 3.9 6.1 25.5 3.7 6.2 5.8 2.2 2 0 0 2 2 2 0 Presenilin Inhibitor_I71 PF12628.7 ETO32840.1 - 6.8 6.5 29.7 0.47 10.3 12.6 2.9 3 0 0 3 3 3 0 Falstatin, cysteine peptidase inhibitor DUF1732 PF08340.11 ETO32841.1 - 0.025 14.6 0.1 0.084 12.9 0.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF1732) Mak10 PF04112.13 ETO32842.1 - 0.00025 20.6 8.3 0.0099 15.4 0.0 4.1 4 1 0 4 4 4 2 Mak10 subunit, NatC N(alpha)-terminal acetyltransferase Comm PF15957.5 ETO32842.1 - 0.022 15.1 1.8 0.035 14.5 0.2 2.1 2 0 0 2 2 2 0 Commissureless Kei1 PF08552.11 ETO32842.1 - 0.14 12.0 6.9 0.8 9.6 0.0 2.5 1 1 1 2 2 2 0 Inositolphosphorylceramide synthase subunit Kei1 DUF2681 PF10883.8 ETO32842.1 - 0.33 11.4 0.0 0.33 11.4 0.0 3.3 3 1 1 4 4 4 0 Protein of unknown function (DUF2681) BT1 PF03092.16 ETO32842.1 - 1 7.5 3.8 8.1 4.5 1.0 2.2 2 0 0 2 2 2 0 BT1 family SID-1_RNA_chan PF13965.6 ETO32842.1 - 4.5 5.5 10.7 1.3e+02 0.7 10.8 2.2 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Vfa1 PF08432.10 ETO32842.1 - 5.1 7.4 32.7 0.035 14.4 19.1 2.9 3 0 0 3 3 3 0 AAA-ATPase Vps4-associated protein 1 Melibiase_2 PF16499.5 ETO32843.1 - 3.9e-33 114.8 1.2 8.5e-33 113.7 1.2 1.4 1 1 0 1 1 1 1 Alpha galactosidase A Tubulin_C PF03953.17 ETO32844.1 - 9.3e-23 80.8 0.1 1.5e-22 80.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin PF00091.25 ETO32844.1 - 0.0051 17.0 0.0 0.0092 16.2 0.0 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain MRJP PF03022.16 ETO32845.1 - 7.5e-47 160.1 1.1 1e-46 159.6 1.1 1.1 1 0 0 1 1 1 1 Major royal jelly protein Reg_prop PF07494.11 ETO32845.1 - 3 8.4 5.4 2.8 8.4 0.0 3.1 3 0 0 3 3 3 0 Two component regulator propeller Macoilin PF09726.9 ETO32846.1 - 0.77 8.2 5.2 0.84 8.1 5.2 1.1 1 0 0 1 1 1 0 Macoilin family IMUP PF15761.5 ETO32846.1 - 0.88 10.3 10.1 7.5 7.3 0.4 2.5 1 1 1 2 2 2 0 Immortalisation up-regulated protein MRP-S32 PF10210.9 ETO32847.1 - 0.27 11.8 0.1 0.27 11.8 0.1 3.5 2 1 0 3 3 3 0 Mitochondrial 28S ribosomal protein S32 TPR_12 PF13424.6 ETO32848.1 - 3.8e-07 30.3 0.1 0.5 10.7 0.1 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32848.1 - 7.8e-05 22.5 3.9 1.4 9.2 0.1 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32848.1 - 0.00015 21.7 0.6 11 6.6 0.0 5.2 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32848.1 - 0.0041 16.8 2.2 22 4.8 0.1 4.1 4 1 1 5 5 5 0 TPR repeat ANAPC3 PF12895.7 ETO32848.1 - 0.007 16.6 5.0 4.9 7.4 0.1 4.5 3 1 1 4 4 4 1 Anaphase-promoting complex, cyclosome, subunit 3 DUF2052 PF09747.9 ETO32848.1 - 0.035 14.3 11.3 0.26 11.4 0.6 2.4 2 0 0 2 2 2 0 Coiled-coil domain containing protein (DUF2052) TPR_1 PF00515.28 ETO32848.1 - 0.035 13.9 5.8 12 6.0 0.4 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat RNA_pol_Rpc4 PF05132.14 ETO32848.1 - 0.045 14.2 7.2 1.4 9.4 1.7 2.4 2 0 0 2 2 2 0 RNA polymerase III RPC4 TPR_14 PF13428.6 ETO32848.1 - 0.078 13.8 0.0 51 5.1 0.0 3.6 4 0 0 4 4 3 0 Tetratricopeptide repeat Connexin PF00029.19 ETO32848.1 - 0.12 12.1 9.1 0.4 10.4 2.4 2.4 2 0 0 2 2 2 0 Connexin Striatin PF08232.12 ETO32848.1 - 0.47 11.0 16.2 0.17 12.5 5.0 3.2 4 0 0 4 4 4 0 Striatin family Tim54 PF11711.8 ETO32848.1 - 1.8 7.3 11.7 4 6.1 3.2 2.4 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 Ctr PF04145.15 ETO32848.1 - 2.4 8.8 4.7 15 6.2 4.7 2.5 1 1 0 1 1 1 0 Ctr copper transporter family SpoIIP PF07454.11 ETO32848.1 - 3.8 6.9 14.9 1 8.8 2.3 2.6 3 0 0 3 3 3 0 Stage II sporulation protein P (SpoIIP) Aminotran_3 PF00202.21 ETO32849.1 - 1e-35 123.2 0.0 1.3e-35 122.9 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-III Beta_elim_lyase PF01212.21 ETO32849.1 - 0.00077 18.8 0.0 0.001 18.4 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase Aminotran_5 PF00266.19 ETO32849.1 - 0.036 13.0 0.4 0.058 12.3 0.4 1.3 1 1 0 1 1 1 0 Aminotransferase class-V NUC130_3NT PF08158.12 ETO32849.1 - 0.18 12.1 2.5 2 8.8 0.1 3.2 3 1 1 4 4 4 0 NUC130/3NT domain Fe-S_biosyn PF01521.20 ETO32850.1 - 3.7e-12 46.4 1.7 4.1e-12 46.3 1.7 1.0 1 0 0 1 1 1 1 Iron-sulphur cluster biosynthesis RGS PF00615.19 ETO32852.1 - 0.0085 16.4 6.2 1.8 8.8 0.1 3.6 3 1 1 4 4 4 2 Regulator of G protein signaling domain NCKAP5 PF15246.6 ETO32852.1 - 3.2 7.3 15.7 0.042 13.5 8.2 1.7 2 0 0 2 2 2 0 Nck-associated protein 5, Peripheral clock protein FmiP_Thoc5 PF09766.9 ETO32853.1 - 5.9e-13 48.8 12.2 1.5e-12 47.5 0.2 2.2 1 1 1 2 2 2 2 Fms-interacting protein/Thoc5 AIP3 PF03915.13 ETO32853.1 - 0.00044 19.5 3.3 0.00056 19.1 3.3 1.2 1 0 0 1 1 1 1 Actin interacting protein 3 HrpE PF06188.12 ETO32853.1 - 0.047 13.6 2.4 0.091 12.6 2.4 1.5 1 1 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E CLN3 PF02487.17 ETO32853.1 - 0.66 9.0 1.7 0.69 8.9 1.7 1.1 1 0 0 1 1 1 0 CLN3 protein FmiP_Thoc5 PF09766.9 ETO32854.1 - 0.00029 20.3 39.1 0.42 9.9 26.7 3.4 1 1 1 2 2 2 2 Fms-interacting protein/Thoc5 FAM75 PF14650.6 ETO32854.1 - 0.011 15.3 17.9 0.011 15.3 17.9 3.1 3 1 1 4 4 4 0 FAM75 family C2 PF00168.30 ETO32856.1 - 0.0078 16.5 0.0 0.088 13.1 0.0 2.4 2 0 0 2 2 2 1 C2 domain WD40 PF00400.32 ETO32858.1 - 1e-25 89.5 27.2 7e-05 23.5 0.1 7.6 6 3 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32858.1 - 1.2e-06 28.7 2.1 0.52 10.6 0.0 5.1 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32858.1 - 1.6e-05 23.7 7.9 0.053 12.2 0.1 4.3 2 2 0 5 5 5 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO32859.1 - 2.6e-57 189.5 15.2 1.4e-09 38.4 0.2 8.0 8 0 0 8 8 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32859.1 - 1.2e-27 96.0 1.0 0.00028 21.1 0.0 7.1 2 1 5 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32859.1 - 6.3e-16 58.6 4.1 2.5e-05 23.7 0.1 4.7 2 2 2 5 5 5 3 WD40-like domain Ge1_WD40 PF16529.5 ETO32859.1 - 4.8e-15 55.3 0.2 0.037 13.0 0.0 6.3 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO32859.1 - 1.8e-09 36.6 1.9 9.5e-05 21.1 0.2 3.9 1 1 3 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO32859.1 - 4e-08 33.0 10.4 0.83 9.7 0.0 6.9 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO32859.1 - 9.1e-07 27.9 1.2 1.3 7.5 0.1 5.7 1 1 2 5 5 5 1 Nucleoporin Nup120/160 Kelch_5 PF13854.6 ETO32859.1 - 1.1e-06 28.4 11.0 0.0028 17.6 0.6 5.5 5 1 1 6 6 6 2 Kelch motif Kelch_1 PF01344.25 ETO32859.1 - 1.6e-05 24.4 0.3 0.014 15.0 0.3 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO32859.1 - 0.00036 20.7 11.0 0.17 12.2 0.2 6.8 7 1 1 8 8 8 1 Kelch motif Nbas_N PF15492.6 ETO32859.1 - 0.00094 18.6 0.4 0.79 9.0 0.0 3.4 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO32859.1 - 0.0011 17.8 0.3 3.3 6.4 0.0 3.8 1 1 2 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nucleoporin_N PF08801.11 ETO32859.1 - 0.0037 16.1 3.7 5.2 5.7 0.3 4.0 1 1 1 3 3 3 1 Nup133 N terminal like Kelch_2 PF07646.15 ETO32859.1 - 0.0042 17.0 4.2 5.4 7.2 0.0 5.1 5 0 0 5 5 4 2 Kelch motif DUF5474 PF17568.2 ETO32859.1 - 0.005 16.9 0.3 6.8 6.8 0.0 3.5 3 0 0 3 3 2 1 Family of unknown function (DUF5474) Ricin_B_lectin PF00652.22 ETO32859.1 - 0.0059 16.9 1.0 1.3 9.3 0.3 3.1 2 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain MRJP PF03022.16 ETO32859.1 - 0.0073 15.7 0.0 0.22 10.8 0.0 2.3 2 0 0 2 2 2 1 Major royal jelly protein PQQ PF01011.21 ETO32859.1 - 0.034 14.1 0.0 26 5.0 0.0 3.9 3 0 0 3 3 3 0 PQQ enzyme repeat Kelch_3 PF13415.6 ETO32859.1 - 0.036 14.4 1.8 0.86 10.0 0.1 3.5 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO32859.1 - 0.13 12.3 0.4 1.5 8.9 0.4 2.9 1 0 0 1 1 1 0 Galactose oxidase, central domain DKNYY PF13644.6 ETO32859.1 - 0.14 12.9 4.2 2.2 9.0 5.3 2.2 1 1 1 2 2 2 0 DKNYY family DUF1943 PF09172.11 ETO32860.1 - 0.041 13.1 0.0 0.38 10.0 0.9 2.0 2 1 0 2 2 2 0 Domain of unknown function (DUF1943) Renin_r PF07850.14 ETO32862.1 - 0.2 12.3 0.9 0.55 10.9 0.9 1.9 1 1 0 1 1 1 0 Renin receptor-like protein RNA_pol_Rpb1_7 PF04990.12 ETO32862.1 - 0.92 9.5 6.5 2 8.4 6.5 1.5 1 1 0 1 1 1 0 RNA polymerase Rpb1, domain 7 AAA_9 PF12781.7 ETO32863.1 - 0.00054 19.2 0.2 0.00087 18.5 0.1 1.4 1 1 0 1 1 1 1 ATP-binding dynein motor region Peroxin-22 PF12827.7 ETO32863.1 - 0.18 11.8 1.0 1.2 9.1 0.1 2.4 1 1 2 3 3 3 0 Peroxisomal biogenesis protein family TB2_DP1_HVA22 PF03134.19 ETO32864.1 - 2.9e-08 33.5 2.6 2.9e-08 33.5 1.4 1.6 1 1 0 1 1 1 1 TB2/DP1, HVA22 family PABP PF00658.18 ETO32865.1 - 6.6e-07 29.4 0.1 1e-06 28.8 0.1 1.3 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain DUF5389 PF17364.2 ETO32865.1 - 0.02 14.9 0.1 0.041 13.9 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5389) AAA PF00004.29 ETO32866.1 - 4.4e-35 121.0 0.0 5.3e-35 120.7 0.0 1.1 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_2 PF07724.14 ETO32866.1 - 1.5e-08 35.0 0.0 2.3e-08 34.4 0.0 1.2 1 0 0 1 1 1 1 AAA domain (Cdc48 subfamily) AAA_22 PF13401.6 ETO32866.1 - 2.8e-06 27.6 0.1 0.068 13.4 0.0 2.1 1 1 1 2 2 2 2 AAA domain AAA_5 PF07728.14 ETO32866.1 - 8.1e-05 22.6 0.1 0.00073 19.5 0.1 2.4 1 1 1 2 2 2 1 AAA domain (dynein-related subfamily) AAA_16 PF13191.6 ETO32866.1 - 0.00026 21.4 0.1 0.0014 19.1 0.2 1.9 1 1 0 1 1 1 1 AAA ATPase domain RuvB_N PF05496.12 ETO32866.1 - 0.00033 20.4 0.0 0.00072 19.3 0.0 1.6 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain Mg_chelatase PF01078.21 ETO32866.1 - 0.00036 20.0 0.0 0.00049 19.5 0.0 1.2 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI DUF2075 PF09848.9 ETO32866.1 - 0.0017 17.7 0.3 0.016 14.5 0.3 1.9 1 1 0 1 1 1 1 Uncharacterized conserved protein (DUF2075) TIP49 PF06068.13 ETO32866.1 - 0.0028 16.9 0.0 0.0033 16.7 0.0 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain ABC_tran PF00005.27 ETO32866.1 - 0.0037 17.8 0.0 0.0046 17.5 0.0 1.2 1 0 0 1 1 1 1 ABC transporter AAA_33 PF13671.6 ETO32866.1 - 0.0043 17.2 0.0 0.0059 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_3 PF07726.11 ETO32866.1 - 0.0052 16.7 0.0 0.0082 16.0 0.0 1.3 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ETO32866.1 - 0.0062 16.9 0.0 0.012 16.0 0.0 1.5 1 1 0 1 1 1 1 RNA helicase AAA_7 PF12775.7 ETO32866.1 - 0.0084 15.6 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_18 PF13238.6 ETO32866.1 - 0.01 16.4 0.0 0.014 15.9 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_24 PF13479.6 ETO32866.1 - 0.011 15.4 0.0 0.02 14.6 0.0 1.3 1 1 0 1 1 1 0 AAA domain ResIII PF04851.15 ETO32866.1 - 0.012 15.6 0.1 0.029 14.4 0.1 1.6 1 1 0 1 1 1 0 Type III restriction enzyme, res subunit TsaE PF02367.17 ETO32866.1 - 0.027 14.5 0.0 0.044 13.8 0.0 1.3 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_11 PF13086.6 ETO32866.1 - 0.028 14.2 0.1 0.047 13.5 0.1 1.3 1 1 0 1 1 1 0 AAA domain Viral_helicase1 PF01443.18 ETO32866.1 - 0.029 14.1 0.0 0.042 13.6 0.0 1.2 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase NACHT PF05729.12 ETO32866.1 - 0.054 13.4 0.1 0.42 10.5 0.0 2.0 2 0 0 2 2 2 0 NACHT domain NB-ARC PF00931.22 ETO32866.1 - 0.08 12.1 0.0 0.098 11.8 0.0 1.3 1 0 0 1 1 1 0 NB-ARC domain Rad17 PF03215.15 ETO32866.1 - 0.09 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 Rad17 P-loop domain ATPase PF06745.13 ETO32866.1 - 0.11 11.8 0.0 0.49 9.7 0.0 1.8 2 0 0 2 2 2 0 KaiC AAA_28 PF13521.6 ETO32866.1 - 0.12 12.7 0.0 0.21 11.8 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO32866.1 - 0.12 12.0 0.0 0.19 11.5 0.0 1.4 1 1 0 1 1 1 0 AAA domain DNA_pol3_delta2 PF13177.6 ETO32866.1 - 0.13 12.0 0.0 0.83 9.4 0.0 2.1 1 1 0 1 1 1 0 DNA polymerase III, delta subunit Parvo_NS1 PF01057.17 ETO32866.1 - 0.14 11.3 0.0 0.21 10.7 0.0 1.2 1 0 0 1 1 1 0 Parvovirus non-structural protein NS1 IstB_IS21 PF01695.17 ETO32866.1 - 0.15 11.8 0.0 0.32 10.7 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activat PF00158.26 ETO32866.1 - 0.16 11.7 0.0 0.28 10.9 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 ETO32866.1 - 0.16 12.0 0.0 0.25 11.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain ANAPC15 PF15243.6 ETO32868.1 - 0.03 14.7 15.2 0.065 13.6 15.2 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 RR_TM4-6 PF06459.12 ETO32868.1 - 0.6 9.9 16.4 0.8 9.5 16.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CSRNP_N PF16019.5 ETO32868.1 - 0.71 9.8 9.8 0.97 9.3 9.8 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PBP1_TM PF14812.6 ETO32868.1 - 1 9.8 19.5 2.4 8.6 19.5 1.8 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Mit_KHE1 PF10173.9 ETO32868.1 - 1.2 9.2 6.4 2 8.5 6.4 1.5 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related CENP-B_dimeris PF09026.10 ETO32868.1 - 1.9 8.9 10.7 3.3 8.1 10.7 1.5 1 0 0 1 1 1 0 Centromere protein B dimerisation domain Pox_Ag35 PF03286.14 ETO32868.1 - 2.6 7.8 20.2 3.5 7.4 19.5 1.5 1 1 0 1 1 1 0 Pox virus Ag35 surface protein Membralin PF09746.9 ETO32868.1 - 4.1 6.3 10.4 4.8 6.1 10.4 1.1 1 0 0 1 1 1 0 Tumour-associated protein DDHD PF02862.17 ETO32868.1 - 7.2 6.7 8.9 8.2 6.5 8.9 1.1 1 0 0 1 1 1 0 DDHD domain FAM176 PF14851.6 ETO32868.1 - 7.7 6.2 16.3 9 5.9 15.6 1.5 1 1 0 1 1 1 0 FAM176 family ubiquitin PF00240.23 ETO32869.1 - 1.6e-09 37.4 0.1 5.4e-09 35.7 0.1 2.0 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO32869.1 - 0.0023 17.7 0.0 0.0083 15.9 0.0 2.0 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like Kelch_6 PF13964.6 ETO32870.1 - 2.8e-06 27.4 2.0 1.5 9.2 0.0 4.4 3 1 1 4 4 4 3 Kelch motif Kelch_4 PF13418.6 ETO32870.1 - 0.00036 20.5 0.0 0.0055 16.7 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO32870.1 - 0.00038 20.0 0.3 0.07 12.7 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO32870.1 - 0.00058 19.7 1.8 0.14 12.2 0.1 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO32870.1 - 0.0013 18.7 3.1 2.9 8.0 0.5 5.1 6 0 0 6 6 6 1 Kelch motif HRDC PF00570.23 ETO32871.1 - 0.11 12.5 0.1 0.24 11.4 0.0 1.5 2 0 0 2 2 2 0 HRDC domain WD40 PF00400.32 ETO32872.1 - 8.8e-20 70.7 11.5 6.2e-06 26.8 0.3 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO32872.1 - 1.8e-05 23.6 2.4 0.03 13.0 0.2 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO32872.1 - 3.4e-05 24.0 0.1 0.15 12.4 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO32873.1 - 2.6e-36 123.0 3.8 1e-11 45.2 0.0 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32873.1 - 5.5e-17 61.8 0.1 2.3e-06 27.8 0.0 3.3 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO32873.1 - 1.1e-09 38.4 0.0 9.8e-06 25.6 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO32873.1 - 9.6e-09 34.6 0.0 0.0005 19.1 0.0 3.0 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32873.1 - 2.2e-08 33.8 0.2 0.011 15.1 0.1 2.8 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO32873.1 - 5.3e-06 25.4 0.0 0.047 12.3 0.0 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO32873.1 - 1.6e-05 24.7 0.2 0.062 13.2 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO32873.1 - 0.00026 19.8 0.6 0.13 11.0 0.0 2.2 1 1 1 2 2 2 2 Nup133 N terminal like Peptidase_S9_N PF02897.15 ETO32873.1 - 0.0011 17.8 0.6 0.0024 16.7 0.6 1.6 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Cytochrom_D1 PF02239.16 ETO32873.1 - 0.002 16.7 0.9 0.011 14.3 0.1 1.9 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nop10p PF04135.12 ETO32873.1 - 0.0074 16.3 0.4 0.99 9.5 0.1 2.4 2 0 0 2 2 2 1 Nucleolar RNA-binding protein, Nop10p family Nbas_N PF15492.6 ETO32873.1 - 0.017 14.5 0.1 4 6.7 0.0 2.3 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO32873.1 - 0.041 14.0 0.0 0.31 11.2 0.0 2.2 2 1 0 2 2 2 0 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO32873.1 - 0.069 12.7 0.0 0.34 10.5 0.0 1.8 1 1 0 1 1 1 0 PQQ-like domain DUF2375 PF09558.10 ETO32873.1 - 0.15 12.1 0.0 1 9.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2375) Big_3_5 PF16640.5 ETO32873.1 - 0.24 11.6 0.0 19 5.5 0.0 2.4 2 1 0 2 2 2 0 Bacterial Ig-like domain (group 3) OPA3 PF07047.12 ETO32874.1 - 4.1e-16 58.9 0.8 4.1e-15 55.6 0.0 2.3 1 1 0 2 2 2 1 Optic atrophy 3 protein (OPA3) Folate_carrier PF01770.18 ETO32874.1 - 0.16 10.7 3.6 0.2 10.4 2.4 1.6 1 1 1 2 2 2 0 Reduced folate carrier UCR_UQCRX_QCR9 PF05365.12 ETO32875.1 - 6.4e-08 32.4 1.6 1.7e-07 31.1 1.6 1.6 1 0 0 1 1 1 1 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like DUF2877 PF11392.8 ETO32876.1 - 0.4 11.4 2.4 0.69 10.6 0.1 2.5 3 1 0 3 3 3 0 Protein of unknown function (DUF2877) Abhydrolase_1 PF00561.20 ETO32877.1 - 0.00014 21.6 0.0 0.00017 21.4 0.0 1.2 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO32877.1 - 0.0025 18.4 0.0 0.003 18.2 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family PsaX PF08078.12 ETO32877.1 - 0.09 12.8 2.6 0.19 11.7 2.6 1.5 1 0 0 1 1 1 0 PsaX family Zeta_toxin PF06414.12 ETO32878.1 - 0.0084 15.4 0.4 0.056 12.7 0.4 2.2 1 1 0 1 1 1 1 Zeta toxin DUF5383 PF17355.2 ETO32878.1 - 4.1 7.8 8.3 5.6 7.4 7.0 1.9 1 1 0 1 1 1 0 Family of unknown function (DUF5383) RNA_pol_A_CTD PF03118.15 ETO32880.1 - 0.021 14.6 0.1 0.03 14.1 0.1 1.3 1 0 0 1 1 1 0 Bacterial RNA polymerase, alpha chain C terminal domain DUF3944 PF13099.6 ETO32880.1 - 0.024 14.5 0.2 0.049 13.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3944) AIG1 PF04548.16 ETO32881.1 - 9.1e-09 35.0 0.0 9.1e-09 35.0 0.0 2.6 3 0 0 3 3 3 1 AIG1 family Pox_A32 PF04665.12 ETO32881.1 - 0.00045 19.8 2.6 0.00046 19.7 0.2 2.2 2 0 0 2 2 2 1 Poxvirus A32 protein FtsK_SpoIIIE PF01580.18 ETO32881.1 - 0.00063 19.2 1.0 0.00092 18.6 0.1 1.7 2 0 0 2 2 2 1 FtsK/SpoIIIE family GTP_EFTU PF00009.27 ETO32881.1 - 0.0023 17.5 0.6 0.039 13.5 0.0 2.5 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain T2SSE PF00437.20 ETO32881.1 - 0.0024 17.0 0.0 0.0068 15.5 0.0 1.7 1 0 0 1 1 1 1 Type II/IV secretion system protein Roc PF08477.13 ETO32881.1 - 0.0044 17.2 1.9 0.0065 16.7 0.1 2.3 2 0 0 2 2 1 1 Ras of Complex, Roc, domain of DAPkinase TrwB_AAD_bind PF10412.9 ETO32881.1 - 0.0046 15.9 0.1 0.02 13.8 0.0 2.0 2 0 0 2 2 2 1 Type IV secretion-system coupling protein DNA-binding domain SMC_N PF02463.19 ETO32881.1 - 0.0053 16.2 0.1 0.015 14.7 0.1 1.8 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain NACHT PF05729.12 ETO32881.1 - 0.0074 16.2 0.0 0.018 14.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_24 PF13479.6 ETO32881.1 - 0.008 15.9 0.8 0.079 12.7 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO32881.1 - 0.0087 16.3 0.0 0.039 14.2 0.0 2.2 1 0 0 1 1 1 1 AAA domain cobW PF02492.19 ETO32881.1 - 0.01 15.4 0.0 0.14 11.7 0.0 2.4 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain ABC_tran PF00005.27 ETO32881.1 - 0.013 16.0 0.2 0.082 13.4 0.0 2.4 2 0 0 2 2 2 0 ABC transporter AAA_16 PF13191.6 ETO32881.1 - 0.013 15.9 0.0 0.043 14.2 0.0 1.9 2 0 0 2 2 1 0 AAA ATPase domain AAA_29 PF13555.6 ETO32881.1 - 0.016 14.9 0.0 0.036 13.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_7 PF12775.7 ETO32881.1 - 0.021 14.3 0.0 0.049 13.1 0.0 1.6 1 0 0 1 1 1 0 P-loop containing dynein motor region PduV-EutP PF10662.9 ETO32881.1 - 0.021 14.5 0.0 0.064 13.0 0.0 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 ETO32881.1 - 0.025 14.9 0.0 0.062 13.6 0.0 2.0 1 1 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETO32881.1 - 0.069 13.2 0.1 0.069 13.2 0.1 3.2 3 2 1 4 4 3 0 50S ribosome-binding GTPase RNA_helicase PF00910.22 ETO32881.1 - 0.084 13.3 0.1 0.084 13.3 0.1 2.9 3 1 1 4 4 4 0 RNA helicase ATP_bind_1 PF03029.17 ETO32881.1 - 0.095 12.5 2.0 0.13 12.0 0.0 2.3 3 0 0 3 3 3 0 Conserved hypothetical ATP binding protein DUF87 PF01935.17 ETO32881.1 - 0.2 11.7 0.0 0.2 11.7 0.0 4.2 3 1 0 3 3 3 0 Helicase HerA, central domain DRE2_N PF16803.5 ETO32881.1 - 0.24 11.7 5.5 2.2 8.6 0.9 3.6 3 1 1 4 4 3 0 Fe-S cluster assembly protein DRE2 N-terminus Dynamin_N PF00350.23 ETO32881.1 - 0.55 10.3 0.0 0.55 10.3 0.0 4.4 4 1 0 4 4 4 0 Dynamin family ResIII PF04851.15 ETO32881.1 - 2.8 7.9 14.2 0.051 13.6 1.5 3.2 2 1 1 3 3 3 0 Type III restriction enzyme, res subunit RabGAP-TBC PF00566.18 ETO32882.1 - 4.8e-43 147.3 3.7 4.8e-43 147.3 3.7 2.7 3 1 0 3 3 3 1 Rab-GTPase-TBC domain Transferase PF02458.15 ETO32882.1 - 0.0056 15.4 1.0 0.0083 14.8 1.0 1.2 1 0 0 1 1 1 1 Transferase family DUF4807 PF16065.5 ETO32882.1 - 0.075 12.7 0.7 3.8 7.2 0.3 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4807) DUF4681 PF15732.5 ETO32882.1 - 0.1 12.9 6.3 0.11 12.8 5.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4681) DUF5394 PF17372.2 ETO32882.1 - 2.3 7.7 8.2 4.2 6.9 7.8 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5394) WD40 PF00400.32 ETO32883.1 - 1.1e-31 108.4 5.3 9.1e-09 35.8 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32883.1 - 2.8e-13 50.0 0.2 0.0012 19.1 0.0 3.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32883.1 - 1.7e-06 27.0 0.1 0.42 9.2 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO32883.1 - 6.4e-06 25.4 0.0 0.36 9.8 0.0 3.1 2 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO32883.1 - 0.0011 18.9 0.0 0.055 13.3 0.0 2.3 1 1 1 2 2 2 1 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO32883.1 - 0.0033 17.3 0.3 7.9 6.5 0.0 3.8 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO32883.1 - 0.0074 15.1 1.3 0.07 11.9 1.4 2.1 1 1 1 2 2 2 2 Nup133 N terminal like WD40_like PF17005.5 ETO32883.1 - 0.011 15.0 0.1 0.79 9.0 0.0 2.6 2 1 1 3 3 3 0 WD40-like domain Nbas_N PF15492.6 ETO32883.1 - 0.014 14.8 0.1 3.4 6.9 0.0 2.7 2 1 1 3 3 3 0 Neuroblastoma-amplified sequence, N terminal HARP PF07443.13 ETO32883.1 - 0.087 12.5 0.2 0.57 9.9 0.0 2.4 3 0 0 3 3 3 0 HepA-related protein (HARP) Cytochrom_D1 PF02239.16 ETO32883.1 - 0.099 11.2 0.0 0.3 9.5 0.0 1.7 2 0 0 2 2 2 0 Cytochrome D1 heme domain WD40 PF00400.32 ETO32884.1 - 4.6e-64 210.8 13.0 1.1e-09 38.7 0.1 8.7 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32884.1 - 4.1e-23 81.5 0.7 0.0093 16.2 0.0 7.2 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32884.1 - 7.4e-13 48.1 1.4 0.027 13.4 0.0 6.5 1 1 6 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO32884.1 - 2.2e-10 40.7 0.0 4.3e-10 39.8 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Nup160 PF11715.8 ETO32884.1 - 6.3e-10 38.3 2.7 0.0045 15.7 0.1 5.3 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO32884.1 - 6.9e-07 28.8 1.9 1.9e-06 27.4 1.9 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) WD40_like PF17005.5 ETO32884.1 - 3.3e-06 26.7 1.1 0.01 15.2 0.1 3.2 1 1 1 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO32884.1 - 1.4e-05 23.8 1.0 0.081 11.4 0.1 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO32884.1 - 7.5e-05 22.6 0.2 3.6 7.6 0.0 4.5 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO32884.1 - 0.00011 21.0 9.2 0.53 9.0 1.0 4.8 2 1 3 5 5 5 2 Nup133 N terminal like AAA_18 PF13238.6 ETO32884.1 - 0.003 18.1 0.0 0.023 15.2 0.0 2.5 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO32884.1 - 0.0089 16.3 0.0 0.045 14.0 0.0 2.2 1 1 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO32884.1 - 0.01 16.2 0.1 0.06 13.7 0.0 2.3 2 1 0 2 2 2 0 AAA ATPase domain Pentapeptide_4 PF13599.6 ETO32884.1 - 0.011 15.9 0.0 0.038 14.2 0.0 1.9 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) AAA PF00004.29 ETO32884.1 - 0.048 14.1 0.1 0.28 11.6 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ETO32884.1 - 0.084 13.3 0.0 0.31 11.4 0.0 2.1 1 0 0 1 1 1 0 RNA helicase Proteasome_A_N PF10584.9 ETO32884.1 - 0.11 12.2 4.6 7.4 6.4 0.1 4.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO32884.1 - 0.14 12.2 0.0 2.7 8.1 0.0 3.0 3 0 0 3 3 3 0 PQQ enzyme repeat AI-2E_transport PF01594.16 ETO32885.1 - 0.0073 15.5 0.1 0.009 15.2 0.1 1.1 1 0 0 1 1 1 1 AI-2E family transporter HTH_34 PF13601.6 ETO32885.1 - 0.0097 16.1 0.2 1.7 8.9 0.0 2.6 3 0 0 3 3 3 1 Winged helix DNA-binding domain Smoothelin PF12510.8 ETO32885.1 - 0.019 15.0 0.1 0.035 14.2 0.1 1.5 1 0 0 1 1 1 0 Smoothelin cytoskeleton protein RTX_C PF08339.10 ETO32885.1 - 0.033 14.3 0.2 0.038 14.0 0.2 1.2 1 0 0 1 1 1 0 RTX C-terminal domain CUE PF02845.16 ETO32885.1 - 0.04 13.6 0.0 0.091 12.5 0.0 1.6 1 0 0 1 1 1 0 CUE domain TruB_N PF01509.18 ETO32885.1 - 0.1 12.9 0.0 0.14 12.5 0.0 1.1 1 0 0 1 1 1 0 TruB family pseudouridylate synthase (N terminal domain) Flavi_NS2B PF01002.19 ETO32885.1 - 0.14 12.0 1.3 1.8 8.4 0.4 2.1 1 1 0 2 2 2 0 Flavivirus non-structural protein NS2B T2SSF PF00482.23 ETO32885.1 - 0.17 11.8 0.6 0.72 9.8 0.6 1.9 1 1 0 1 1 1 0 Type II secretion system (T2SS), protein F WD40 PF00400.32 ETO32886.1 - 1.2e-40 136.7 24.3 9.6e-08 32.6 0.2 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32886.1 - 5e-11 42.8 0.7 0.0078 16.5 0.0 5.2 5 2 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32886.1 - 8.5e-09 34.6 3.6 0.19 10.4 0.0 5.4 2 2 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO32886.1 - 8.9e-06 25.2 9.1 0.001 18.5 1.7 4.3 2 2 3 5 5 5 2 WD40-like domain zf-TRAF PF02176.18 ETO32887.1 - 4e-05 24.2 7.7 4e-05 24.2 7.7 2.8 2 1 0 2 2 2 1 TRAF-type zinc finger HALZ PF02183.18 ETO32887.1 - 0.014 15.6 3.4 0.034 14.4 3.4 1.6 1 0 0 1 1 1 0 Homeobox associated leucine zipper Fzo_mitofusin PF04799.13 ETO32887.1 - 0.15 11.6 2.7 2.9 7.4 0.0 2.1 2 0 0 2 2 2 0 fzo-like conserved region Sina PF03145.16 ETO32887.1 - 0.21 11.5 8.5 0.34 10.8 6.2 2.4 1 1 2 3 3 3 0 Seven in absentia protein family PTCB-BRCT PF12738.7 ETO32891.1 - 8.2e-39 131.4 19.6 5.2e-12 45.5 1.3 5.4 5 0 0 5 5 5 4 twin BRCT domain BRCT PF00533.26 ETO32891.1 - 9.9e-29 99.6 25.3 3.3e-11 43.4 0.1 7.5 8 1 1 9 9 9 4 BRCA1 C Terminus (BRCT) domain BRCT_2 PF16589.5 ETO32891.1 - 5.7e-18 65.1 16.9 0.0047 17.3 0.2 7.7 8 1 0 8 8 8 6 BRCT domain, a BRCA1 C-terminus domain LIG3_BRCT PF16759.5 ETO32891.1 - 3.8e-15 55.9 8.7 2.8e-06 27.5 0.0 5.7 5 0 0 5 5 5 3 DNA ligase 3 BRCT domain RTT107_BRCT_5 PF16770.5 ETO32891.1 - 1.1e-10 41.2 5.5 0.00099 19.0 0.1 6.4 7 0 0 7 7 7 3 Regulator of Ty1 transposition protein 107 BRCT domain BRCT_3 PF18428.1 ETO32891.1 - 3.2e-08 33.5 7.8 0.0036 17.3 0.1 6.1 5 1 0 5 5 5 2 BRCA1 C Terminus (BRCT) domain Vwaint PF14624.6 ETO32892.1 - 0.11 12.6 0.1 0.19 11.9 0.1 1.5 1 0 0 1 1 1 0 VWA / Hh protein intein-like WD40 PF00400.32 ETO32893.1 - 0.00058 20.6 0.3 0.9 10.5 0.0 3.3 2 1 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO32893.1 - 0.02 13.6 0.0 0.025 13.2 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Bac_A_amyl_C PF18612.1 ETO32893.1 - 0.037 13.8 0.3 0.11 12.3 0.2 1.9 1 1 0 1 1 1 0 Bacterial Alpha amylase C-terminal domain PAZ_siRNAbind PF12212.8 ETO32894.1 - 0.091 12.6 0.0 0.18 11.6 0.0 1.4 1 0 0 1 1 1 0 PAZ domain zf-TRAF PF02176.18 ETO32895.1 - 0.0002 22.0 0.2 0.0002 22.0 0.2 3.7 4 1 1 5 5 5 1 TRAF-type zinc finger zf-C3HC4_4 PF15227.6 ETO32895.1 - 0.0012 19.0 7.2 0.0012 19.0 7.2 2.5 2 0 0 2 2 2 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ETO32895.1 - 0.0052 16.8 6.7 0.0052 16.8 6.7 2.4 2 0 0 2 2 2 1 RING-type zinc-finger zf-RING_14 PF17978.1 ETO32895.1 - 0.13 12.7 7.0 0.15 12.5 3.1 2.7 2 0 0 2 2 2 0 RING/Ubox like zinc-binding domain zf-RING_6 PF14835.6 ETO32895.1 - 0.19 11.6 4.1 0.17 11.8 1.8 2.2 2 0 0 2 2 2 0 zf-RING of BARD1-type protein zf-RING_2 PF13639.6 ETO32895.1 - 1.3 9.4 15.5 0.19 12.1 7.5 3.5 3 0 0 3 3 3 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO32895.1 - 5.2 7.0 15.5 0.39 10.6 6.5 3.5 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Kelch_1 PF01344.25 ETO32897.1 - 3.1e-05 23.5 5.1 0.11 12.1 0.0 4.0 4 1 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO32897.1 - 3.5e-05 23.6 0.7 0.077 13.0 0.1 3.1 2 1 1 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO32897.1 - 0.00032 20.6 0.0 0.0015 18.5 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO32897.1 - 0.00038 20.6 0.1 0.16 12.3 0.0 2.5 2 0 0 2 2 2 2 Kelch motif adh_short PF00106.25 ETO32898.1 - 1.9e-09 37.2 0.0 3.8e-09 36.3 0.0 1.4 1 0 0 1 1 1 1 short chain dehydrogenase Pribosyltran PF00156.27 ETO32899.1 - 2.4e-28 98.6 0.1 3.7e-28 98.0 0.1 1.2 1 0 0 1 1 1 1 Phosphoribosyl transferase domain UPRTase PF14681.6 ETO32899.1 - 0.0055 16.2 0.0 0.0079 15.7 0.0 1.2 1 0 0 1 1 1 1 Uracil phosphoribosyltransferase PRTase_2 PF15609.6 ETO32899.1 - 0.066 12.7 0.1 0.18 11.3 0.1 1.6 1 1 0 1 1 1 0 Phosphoribosyl transferase Citrate_synt PF00285.21 ETO32900.1 - 4.2e-50 170.8 0.5 7.2e-50 170.1 0.1 1.5 2 0 0 2 2 2 1 Citrate synthase, C-terminal domain MCM_OB PF17207.3 ETO32900.1 - 0.027 14.3 2.3 0.12 12.2 0.0 2.1 1 1 1 2 2 2 0 MCM OB domain Citrate_synt PF00285.21 ETO32901.1 - 2.9e-29 102.3 0.0 2.3e-17 63.1 0.0 2.1 2 0 0 2 2 2 2 Citrate synthase, C-terminal domain TPT PF03151.16 ETO32902.1 - 1.6e-24 86.8 17.8 2.3e-23 83.0 17.8 1.9 1 1 0 1 1 1 1 Triose-phosphate Transporter family EamA PF00892.20 ETO32902.1 - 2.8e-08 34.0 11.3 0.004 17.3 0.0 3.2 3 0 0 3 3 3 3 EamA-like transporter family UAA PF08449.11 ETO32902.1 - 0.0017 17.7 17.9 0.0039 16.5 17.9 1.7 1 1 0 1 1 1 1 UAA transporter family TMEM234 PF10639.9 ETO32902.1 - 0.0043 17.1 2.0 0.01 15.9 0.4 2.3 2 0 0 2 2 2 1 Putative transmembrane family 234 DUF5336 PF17270.2 ETO32902.1 - 0.0065 16.1 0.8 0.033 13.8 0.1 2.5 2 1 0 2 2 2 1 Family of unknown function (DUF5336) DUF5367 PF17329.2 ETO32902.1 - 0.0088 16.1 0.3 0.0088 16.1 0.3 2.9 3 1 0 3 3 3 1 Family of unknown function (DUF5367) Cyt_bd_oxida_II PF02322.15 ETO32902.1 - 0.075 12.4 14.6 0.38 10.1 0.4 2.1 2 0 0 2 2 2 0 Cytochrome bd terminal oxidase subunit II DUF4514 PF14986.6 ETO32902.1 - 0.08 12.9 1.8 0.087 12.8 0.3 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4514) Adap_comp_sub PF00928.21 ETO32903.1 - 6.8e-06 25.6 0.1 1.4e-05 24.6 0.0 1.6 2 0 0 2 2 2 1 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETO32903.1 - 0.029 14.3 0.1 2.8 7.8 0.1 2.3 2 0 0 2 2 2 0 Clathrin adaptor complex small chain RGS PF00615.19 ETO32904.1 - 1e-05 25.8 0.1 9.1e-05 22.7 0.1 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain PSII_Pbs31 PF18240.1 ETO32904.1 - 0.041 14.3 0.0 0.083 13.3 0.0 1.4 1 0 0 1 1 1 0 Photosystem II Psb31 protein EVI2A PF05399.11 ETO32906.1 - 0.0017 18.0 3.0 0.0017 18.0 3.0 2.4 2 0 0 2 2 2 1 Ectropic viral integration site 2A protein (EVI2A) DUF5383 PF17355.2 ETO32906.1 - 0.0027 18.1 0.8 0.0027 18.1 0.8 4.3 3 1 1 4 4 4 1 Family of unknown function (DUF5383) Utp14 PF04615.13 ETO32906.1 - 0.06 11.9 23.0 0.088 11.4 23.0 1.2 1 0 0 1 1 1 0 Utp14 protein BUD22 PF09073.10 ETO32906.1 - 0.08 12.3 22.2 0.12 11.7 22.2 1.3 1 0 0 1 1 1 0 BUD22 Gemini_mov PF01708.16 ETO32906.1 - 0.21 11.4 2.2 2.7 7.8 0.0 2.9 3 0 0 3 3 3 0 Geminivirus putative movement protein YL1 PF05764.13 ETO32906.1 - 1.7 8.7 32.1 2 8.5 10.6 2.2 2 0 0 2 2 2 0 YL1 nuclear protein Shisa PF13908.6 ETO32906.1 - 2.4 8.4 10.3 1.7 8.8 0.0 3.2 2 1 1 3 3 3 0 Wnt and FGF inhibitory regulator DUF4407 PF14362.6 ETO32906.1 - 4.2 6.6 6.3 6.8 5.9 6.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Tim54 PF11711.8 ETO32906.1 - 4.8 5.9 14.2 0.53 9.0 5.8 2.3 2 0 0 2 2 2 0 Inner membrane protein import complex subunit Tim54 SLC35F PF06027.12 ETO32906.1 - 8.4 5.8 8.7 6.2 6.2 4.0 2.1 2 0 0 2 2 2 0 Solute carrier family 35 CDC45 PF02724.14 ETO32906.1 - 9 4.4 29.6 2.5 6.3 5.9 2.1 2 0 0 2 2 2 0 CDC45-like protein KleE PF17394.2 ETO32907.1 - 0.01 16.1 0.2 0.023 14.9 0.0 1.6 2 0 0 2 2 2 0 Uncharacterized KleE stable inheritance protein Yos1 PF08571.10 ETO32909.1 - 0.11 12.7 0.1 0.11 12.7 0.1 1.7 2 0 0 2 2 2 0 Yos1-like Ion_trans PF00520.31 ETO32910.1 - 0.0041 16.4 0.4 0.0064 15.7 0.4 1.2 1 0 0 1 1 1 1 Ion transport protein PAP1 PF08601.10 ETO32910.1 - 0.0085 15.9 3.9 0.0085 15.9 3.9 3.3 2 1 1 3 3 3 1 Transcription factor PAP1 CSG2 PF16965.5 ETO32910.1 - 0.015 14.2 0.7 0.015 14.2 0.7 2.6 2 1 0 2 2 2 0 Ceramide synthase regulator V_ATPase_I PF01496.19 ETO32910.1 - 0.025 12.5 0.1 0.025 12.5 0.1 2.6 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Connexin PF00029.19 ETO32910.1 - 0.11 12.2 0.2 0.11 12.2 0.2 3.1 3 1 0 3 3 3 0 Connexin OATP PF03137.20 ETO32910.1 - 7.6 4.7 5.6 0.72 8.1 0.3 1.9 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family Methyltransf_32 PF13679.6 ETO32911.1 - 1.8e-06 28.0 1.9 3.2e-06 27.2 1.9 1.4 1 0 0 1 1 1 1 Methyltransferase domain DC_STAMP PF07782.13 ETO32911.1 - 0.0012 18.7 2.7 0.0014 18.5 2.7 1.1 1 0 0 1 1 1 1 DC-STAMP-like protein MTS PF05175.14 ETO32912.1 - 0.012 15.2 0.0 0.021 14.4 0.0 1.4 1 1 0 1 1 1 0 Methyltransferase small domain YihI PF04220.12 ETO32912.1 - 0.029 14.1 0.8 0.04 13.7 0.8 1.2 1 0 0 1 1 1 0 Der GTPase activator (YihI) Methyltransf_32 PF13679.6 ETO32912.1 - 0.033 14.2 0.2 0.055 13.5 0.0 1.5 2 0 0 2 2 2 0 Methyltransferase domain DAO PF01266.24 ETO32913.1 - 9.9e-14 51.7 0.0 1.1e-13 51.5 0.0 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Pyr_redox_2 PF07992.14 ETO32913.1 - 0.003 16.8 0.0 0.0056 15.9 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase HI0933_like PF03486.14 ETO32913.1 - 0.1 11.3 0.0 0.15 10.7 0.0 1.2 1 0 0 1 1 1 0 HI0933-like protein FAD_binding_3 PF01494.19 ETO32913.1 - 0.19 10.9 0.0 0.25 10.5 0.0 1.2 1 0 0 1 1 1 0 FAD binding domain Menin PF05053.13 ETO32914.1 - 0.3 9.4 7.9 0.43 8.9 7.9 1.1 1 0 0 1 1 1 0 Menin IF4E PF01652.18 ETO32915.1 - 6.7e-41 139.7 1.0 8.4e-41 139.4 1.0 1.1 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E Trefoil PF00088.18 ETO32916.1 - 9.1e-13 47.9 9.3 1.8e-12 46.9 9.3 1.5 1 0 0 1 1 1 1 Trefoil (P-type) domain Glyco_hydro_15 PF00723.21 ETO32916.1 - 2e-06 26.8 0.0 2.8e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Glycosyl hydrolases family 15 RGS PF00615.19 ETO32917.1 - 7.5e-10 39.1 0.6 1.7e-09 38.0 0.6 1.6 1 0 0 1 1 1 1 Regulator of G protein signaling domain STAT_int PF02865.17 ETO32917.1 - 0.012 16.1 0.5 0.028 14.9 0.1 1.9 2 0 0 2 2 2 0 STAT protein, protein interaction domain CPSase_L_D2 PF02786.17 ETO32917.1 - 0.15 11.5 0.1 0.27 10.7 0.1 1.3 1 0 0 1 1 1 0 Carbamoyl-phosphate synthase L chain, ATP binding domain VWA PF00092.28 ETO32919.1 - 4.5e-08 33.5 0.6 8.1e-08 32.7 0.6 1.4 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_2 PF13519.6 ETO32919.1 - 2.8e-05 24.7 0.0 3.9e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 von Willebrand factor type A domain DER1 PF04511.15 ETO32919.1 - 0.014 15.3 1.1 0.026 14.5 1.1 1.4 1 0 0 1 1 1 0 Der1-like family DUF2985 PF11204.8 ETO32919.1 - 0.038 14.1 0.1 0.089 13.0 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2985) SpoIIIAH PF12685.7 ETO32920.1 - 0.0063 16.4 0.9 0.0063 16.4 0.9 2.2 2 0 0 2 2 2 1 SpoIIIAH-like protein ShK PF01549.24 ETO32920.1 - 0.076 13.6 9.3 0.18 12.3 9.3 1.7 1 0 0 1 1 1 0 ShK domain-like TFIIA PF03153.13 ETO32921.1 - 0.025 14.6 19.5 0.033 14.2 19.5 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DUF373 PF04123.13 ETO32921.1 - 0.034 13.6 2.5 0.047 13.1 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF373) DUF3784 PF12650.7 ETO32921.1 - 0.038 14.2 6.7 0.98 9.7 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) Sin_N PF04801.13 ETO32921.1 - 0.19 10.9 17.2 0.78 8.9 0.0 2.1 2 0 0 2 2 2 0 Sin-like protein conserved region DUF1218 PF06749.12 ETO32921.1 - 0.5 10.9 4.3 6.7 7.3 3.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF1218) Sigma_reg_N PF13800.6 ETO32921.1 - 6.6 7.1 10.9 1.6 9.1 4.1 2.8 3 0 0 3 3 3 0 Sigma factor regulator N-terminal RRM_1 PF00076.22 ETO32922.1 - 3.5e-19 68.4 0.0 7.6e-19 67.3 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO32922.1 - 0.0022 18.0 0.0 0.0058 16.6 0.0 1.7 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ETO32922.1 - 0.01 16.0 0.1 0.061 13.4 0.0 2.2 2 1 0 2 2 2 0 RNA recognition motif RRM_occluded PF16842.5 ETO32922.1 - 0.012 15.4 0.0 0.027 14.3 0.0 1.6 1 0 0 1 1 1 0 Occluded RNA-recognition motif RRM_5 PF13893.6 ETO32922.1 - 0.016 14.8 0.0 0.028 14.0 0.0 1.4 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO32922.1 - 0.023 14.7 0.3 0.29 11.2 0.0 2.3 2 0 0 2 2 2 0 RNA binding motif zf-C3HC4_3 PF13920.6 ETO32923.1 - 2 8.3 10.3 0.78 9.7 2.2 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO32923.1 - 2.1 8.3 6.6 0.62 10.0 2.7 2.2 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) SPX PF03105.19 ETO32924.1 - 5.6e-09 36.4 32.3 5.6e-09 36.4 32.3 2.4 1 1 1 2 2 2 1 SPX domain EGF PF00008.27 ETO32927.1 - 0.029 14.7 0.6 0.029 14.7 0.6 2.3 2 0 0 2 2 2 0 EGF-like domain PHD PF00628.29 ETO32928.1 - 1.2e-11 44.3 20.9 1.6e-08 34.3 4.4 2.9 2 0 0 2 2 2 2 PHD-finger C1_1 PF00130.22 ETO32928.1 - 0.0064 16.3 4.3 0.0064 16.3 4.3 3.6 3 1 0 3 3 3 1 Phorbol esters/diacylglycerol binding domain (C1 domain) DUF2155 PF09923.9 ETO32928.1 - 0.019 15.2 0.0 0.048 13.9 0.0 1.6 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2155) zf-HC5HC2H_2 PF13832.6 ETO32928.1 - 0.059 13.5 22.4 0.023 14.8 9.1 2.9 1 1 0 2 2 2 0 PHD-zinc-finger like domain zf-HC5HC2H PF13771.6 ETO32928.1 - 0.18 12.1 22.6 0.11 12.7 9.6 2.9 1 1 2 3 3 3 0 PHD-like zinc-binding domain zf-MIZ PF02891.20 ETO32928.1 - 0.25 11.1 10.5 1.2 9.0 2.7 3.0 2 1 0 2 2 2 0 MIZ/SP-RING zinc finger FANCL_C PF11793.8 ETO32928.1 - 2 8.7 29.1 0.57 10.4 6.6 4.5 3 1 2 5 5 5 0 FANCL C-terminal domain WD40 PF00400.32 ETO32929.1 - 1.8e-36 123.5 48.0 1e-06 29.4 0.1 10.6 7 5 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32929.1 - 1.2e-13 51.2 0.2 0.0028 17.9 0.0 6.0 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32929.1 - 2.8e-09 36.2 21.9 0.047 12.3 0.2 6.2 1 1 4 6 6 6 6 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO32929.1 - 0.0075 16.9 0.9 0.044 14.5 0.9 2.4 1 0 0 1 1 1 1 TRAF-type zinc finger DUF4407 PF14362.6 ETO32929.1 - 0.056 12.8 1.2 0.13 11.6 1.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Laminin_II PF06009.12 ETO32929.1 - 0.2 11.6 4.9 0.46 10.5 4.9 1.5 1 0 0 1 1 1 0 Laminin Domain II CAC1F_C PF16885.5 ETO32930.1 - 1.4 8.5 11.6 1.7 8.2 11.6 1.3 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term p450 PF00067.22 ETO32933.1 - 8.9e-14 51.1 0.0 1.2e-13 50.7 0.0 1.1 1 0 0 1 1 1 1 Cytochrome P450 Minor_capsid_1 PF10665.9 ETO32933.1 - 0.076 13.2 0.0 12 6.2 0.0 2.3 2 0 0 2 2 2 0 Minor capsid protein LRRC37AB_C PF14914.6 ETO32936.1 - 4.3 7.2 11.6 0.21 11.5 2.5 2.5 3 0 0 3 3 3 0 LRRC37A/B like protein 1 C-terminal domain 3HCDH PF00725.22 ETO32937.1 - 1.1e-17 64.5 0.0 2.7e-17 63.2 0.0 1.7 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain 3HCDH_N PF02737.18 ETO32938.1 - 3e-22 79.4 0.0 3.9e-22 79.0 0.0 1.1 1 0 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ETO32938.1 - 0.00013 21.6 0.0 0.00015 21.4 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ETO32938.1 - 0.00027 20.3 0.0 0.00036 19.9 0.0 1.3 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain Ldh_1_N PF00056.23 ETO32938.1 - 0.00038 20.5 0.0 0.00059 20.0 0.0 1.3 1 0 0 1 1 1 1 lactate/malate dehydrogenase, NAD binding domain AlaDh_PNT_C PF01262.21 ETO32938.1 - 0.0017 17.7 0.0 0.0018 17.6 0.0 1.2 1 0 0 1 1 1 1 Alanine dehydrogenase/PNT, C-terminal domain ApbA PF02558.16 ETO32938.1 - 0.0059 16.3 0.1 0.017 14.7 0.0 1.6 1 1 1 2 2 2 1 Ketopantoate reductase PanE/ApbA NAD_binding_2 PF03446.15 ETO32938.1 - 0.0093 16.1 0.0 0.013 15.7 0.0 1.5 1 1 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase adh_short PF00106.25 ETO32938.1 - 0.011 15.2 0.0 0.018 14.5 0.0 1.5 1 1 0 1 1 1 0 short chain dehydrogenase NAD_Gly3P_dh_N PF01210.23 ETO32938.1 - 0.017 15.1 0.1 0.034 14.1 0.1 1.5 1 1 0 1 1 1 0 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus UPF0146 PF03686.13 ETO32938.1 - 0.16 11.9 0.0 0.25 11.2 0.0 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0146) DUF349 PF03993.12 ETO32938.1 - 0.4 11.0 4.4 12 6.3 0.5 2.3 1 1 1 2 2 2 0 Domain of Unknown Function (DUF349) PUL PF08324.11 ETO32939.1 - 4e-08 32.8 7.4 1.7e-07 30.8 1.1 2.4 2 1 0 2 2 2 2 PUL domain DUF2845 PF11006.8 ETO32939.1 - 0.13 12.3 0.0 0.4 10.8 0.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2845) SAM_1 PF00536.30 ETO32940.1 - 0.0063 16.9 0.0 0.013 15.9 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RskA PF10099.9 ETO32940.1 - 0.06 13.7 1.4 0.16 12.3 1.4 1.6 1 0 0 1 1 1 0 Anti-sigma-K factor rskA Cadherin_C_2 PF16492.5 ETO32940.1 - 0.15 12.8 0.0 0.15 12.8 0.0 4.4 4 1 0 4 4 4 0 Cadherin cytoplasmic C-terminal Sec6 PF06046.13 ETO32941.1 - 1.2e-40 139.5 21.1 1.4e-40 139.2 21.1 1.1 1 0 0 1 1 1 1 Exocyst complex component Sec6 TaqI_C PF12950.7 ETO32941.1 - 0.016 15.3 0.6 0.12 12.4 0.4 2.5 2 1 0 2 2 2 0 TaqI-like C-terminal specificity domain kleA_kleC PF17383.2 ETO32941.1 - 0.11 12.8 0.3 0.83 10.0 0.1 2.3 2 0 0 2 2 2 0 Uncharacterized KorC regulated protein A V-SNARE_C PF12352.8 ETO32941.1 - 0.14 12.5 0.2 0.3 11.4 0.2 1.5 1 0 0 1 1 1 0 Snare region anchored in the vesicle membrane C-terminus Menin PF05053.13 ETO32942.1 - 0.01 14.2 3.3 0.013 13.9 3.3 1.2 1 0 0 1 1 1 0 Menin PDGF_N PF04692.13 ETO32942.1 - 0.18 12.6 1.2 0.37 11.6 0.1 2.1 3 0 0 3 3 3 0 Platelet-derived growth factor, N terminal region Secretin_N_2 PF07655.13 ETO32942.1 - 5.9 7.5 15.9 4.4 7.9 13.6 2.0 2 0 0 2 2 2 0 Secretin N-terminal domain RasGEF_N PF00618.20 ETO32944.1 - 0.00067 19.9 0.1 0.0018 18.4 0.1 1.7 1 0 0 1 1 1 1 RasGEF N-terminal motif WD40 PF00400.32 ETO32946.1 - 2.9e-41 138.6 28.1 3.3e-08 34.0 1.2 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32946.1 - 3.3e-13 49.7 6.1 0.091 13.1 0.0 6.3 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32946.1 - 3.3e-12 45.9 3.8 0.073 11.7 0.0 5.9 3 1 1 5 5 5 4 Nucleoporin Nup120/160 Mito_fiss_reg PF05308.11 ETO32946.1 - 0.0022 18.1 1.8 0.0036 17.4 1.8 1.2 1 0 0 1 1 1 1 Mitochondrial fission regulator KLRAQ PF10205.9 ETO32946.1 - 0.0088 16.3 3.3 0.0088 16.3 3.3 2.5 1 1 0 2 2 2 1 Predicted coiled-coil domain-containing protein TPD52 PF04201.15 ETO32946.1 - 0.59 9.7 6.1 0.55 9.8 4.6 1.7 1 1 0 1 1 1 0 Tumour protein D52 family TPR_12 PF13424.6 ETO32948.1 - 5.8e-19 68.2 1.2 1.3e-14 54.3 0.6 2.1 1 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32948.1 - 8.9e-16 57.0 10.4 3.4e-09 36.1 1.1 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32948.1 - 1.9e-15 56.1 1.1 2.5e-09 36.7 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32948.1 - 1.2e-13 50.0 0.6 0.00013 21.7 0.1 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32948.1 - 1.7e-12 46.5 7.1 3.1e-06 26.9 0.3 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32948.1 - 1.7e-09 37.1 8.0 9.7e-05 22.2 0.5 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat SNAP PF14938.6 ETO32948.1 - 1.5e-07 31.1 1.3 2.1e-07 30.7 1.3 1.2 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO32948.1 - 2.1e-06 27.7 4.2 0.089 12.9 0.0 3.2 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO32948.1 - 7.6e-05 22.5 4.6 0.00021 21.1 4.3 1.7 1 1 1 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETO32948.1 - 0.00013 21.5 11.7 0.0022 17.7 0.4 3.6 3 2 2 5 5 5 2 TPR repeat TPR_17 PF13431.6 ETO32948.1 - 0.00028 21.1 4.2 0.23 11.9 1.1 3.4 2 2 1 3 3 3 2 Tetratricopeptide repeat DUF5113 PF17140.4 ETO32948.1 - 0.00088 19.1 4.0 0.00088 19.1 4.0 2.3 1 1 2 3 3 3 1 Domain of unknown function (DUF5113) TPR_14 PF13428.6 ETO32948.1 - 0.0026 18.4 0.0 11 7.2 0.0 3.2 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO32948.1 - 0.0027 18.2 0.4 4.5 8.1 0.0 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat DUF3856 PF12968.7 ETO32948.1 - 0.03 14.4 0.1 0.04 14.0 0.1 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF3856) TPR_MalT PF17874.1 ETO32948.1 - 0.031 13.7 0.2 0.033 13.6 0.2 1.1 1 0 0 1 1 1 0 MalT-like TPR region RPN7 PF10602.9 ETO32948.1 - 0.036 13.8 2.4 4.1 7.1 0.1 2.4 1 1 1 2 2 2 0 26S proteasome subunit RPN7 TEX29 PF15839.5 ETO32948.1 - 0.048 14.3 0.1 13 6.5 0.0 2.5 1 1 1 2 2 2 0 Testis-expressed sequence 29 protein Formyl_trans_C PF02911.18 ETO32948.1 - 0.069 13.4 0.0 0.12 12.6 0.0 1.4 1 0 0 1 1 1 0 Formyl transferase, C-terminal domain ANAPC3 PF12895.7 ETO32948.1 - 0.1 12.8 7.0 0.43 10.8 3.9 2.2 1 1 1 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 SHNi-TPR PF10516.9 ETO32948.1 - 0.1 12.0 0.0 1.9 8.0 0.0 2.2 2 0 0 2 2 2 0 SHNi-TPR MotB_plug PF13677.6 ETO32948.1 - 0.12 12.0 0.5 0.74 9.5 0.1 2.1 2 0 0 2 2 2 0 Membrane MotB of proton-channel complex MotA/MotB NSF PF02071.20 ETO32948.1 - 0.27 12.1 13.0 1.9 9.6 0.3 4.2 3 0 0 3 3 3 0 Aromatic-di-Alanine (AdAR) repeat TPR_12 PF13424.6 ETO32949.1 - 4.6e-23 81.3 0.2 4.7e-12 46.0 0.1 2.3 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO32949.1 - 9.8e-14 50.5 9.2 6.3e-08 32.1 3.0 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO32949.1 - 1.3e-13 50.3 0.0 1.1e-07 31.5 0.0 3.3 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO32949.1 - 1e-11 44.0 4.4 3.9e-06 26.5 1.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO32949.1 - 4.7e-08 32.5 0.0 3.3e-06 26.7 0.0 3.1 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO32949.1 - 6.1e-08 32.3 9.7 0.00024 21.1 1.8 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO32949.1 - 2.1e-07 30.5 1.7 0.016 14.9 0.6 3.4 3 0 0 3 3 3 2 TPR repeat TPR_17 PF13431.6 ETO32949.1 - 0.00019 21.5 1.3 0.33 11.4 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat MIT PF04212.18 ETO32949.1 - 0.0015 18.6 0.3 0.017 15.2 0.1 2.5 2 0 0 2 2 2 1 MIT (microtubule interacting and transport) domain SNAP PF14938.6 ETO32949.1 - 0.0019 17.7 0.3 0.0032 16.9 0.3 1.3 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP TPR_19 PF14559.6 ETO32949.1 - 0.011 16.3 0.0 0.026 15.0 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO32949.1 - 0.069 13.8 0.6 0.41 11.4 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO32949.1 - 0.14 12.2 0.3 0.14 12.2 0.3 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat WD40 PF00400.32 ETO32950.1 - 7.9e-59 194.3 25.9 1.6e-08 35.1 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO32950.1 - 9.5e-13 47.8 1.2 0.019 14.0 0.0 6.2 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO32950.1 - 2.8e-10 40.3 1.4 0.4 11.0 0.1 5.3 1 1 5 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32950.1 - 2.8e-09 36.8 3.1 0.019 14.3 0.1 4.0 2 2 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO32950.1 - 4.1e-09 35.6 8.2 0.8 8.3 0.0 6.4 1 1 6 7 7 7 5 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO32950.1 - 4.2e-06 26.8 0.1 4.2 7.6 0.0 4.3 3 1 0 4 4 4 2 Strictosidine synthase Nbas_N PF15492.6 ETO32950.1 - 2.9e-05 23.5 5.7 0.035 13.4 0.4 4.4 2 2 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO32950.1 - 0.00063 19.6 8.6 7.1 6.7 0.1 5.1 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Plk4_PB1 PF18190.1 ETO32950.1 - 0.17 12.1 4.5 3.6 7.8 0.1 3.8 3 1 1 5 5 5 0 Polo-like Kinase 4 Polo Box 1 Cytochrom_D1 PF02239.16 ETO32950.1 - 0.26 9.8 2.1 2 6.9 0.2 2.6 2 1 1 3 3 3 0 Cytochrome D1 heme domain Pex14_N PF04695.13 ETO32951.1 - 0.00091 19.9 4.8 0.0011 19.6 4.8 1.1 1 0 0 1 1 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region Dicty_REP PF05086.12 ETO32951.1 - 0.037 12.0 10.5 0.041 11.9 10.5 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein AUDH_Cupin PF18637.1 ETO32951.1 - 0.043 13.8 3.8 0.058 13.4 3.8 1.1 1 0 0 1 1 1 0 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain DUF999 PF06198.11 ETO32951.1 - 0.071 13.1 0.9 0.09 12.8 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF999) Med3 PF11593.8 ETO32951.1 - 0.12 11.5 12.9 0.15 11.2 12.9 1.0 1 0 0 1 1 1 0 Mediator complex subunit 3 fungal CDC45 PF02724.14 ETO32951.1 - 0.18 10.1 9.7 0.22 9.8 9.7 1.0 1 0 0 1 1 1 0 CDC45-like protein Complex1_LYR_2 PF13233.6 ETO32951.1 - 0.74 10.6 7.8 76 4.2 7.8 2.4 1 1 0 1 1 1 0 Complex1_LYR-like DNA_pol_delta_4 PF04081.13 ETO32951.1 - 2 8.7 11.7 3.3 8.0 11.7 1.5 1 1 0 1 1 1 0 DNA polymerase delta, subunit 4 DUF4612 PF15389.6 ETO32951.1 - 2 9.5 10.9 5.5 8.1 10.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4612) Presenilin PF01080.17 ETO32951.1 - 2.7 6.7 7.7 2.9 6.6 7.7 1.1 1 0 0 1 1 1 0 Presenilin DUF2681 PF10883.8 ETO32952.1 - 5.1 7.6 6.8 9.1 6.8 6.8 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2681) Sulfotransfer_4 PF17784.1 ETO32953.1 - 1.3e-18 67.6 0.0 2.9e-18 66.5 0.0 1.6 1 1 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO32953.1 - 0.00048 20.6 0.3 0.64 10.4 0.0 2.4 1 1 0 2 2 2 2 Sulfotransferase family PAP_assoc PF03828.19 ETO32955.1 - 1e-15 57.6 0.6 5.3e-15 55.4 0.1 2.2 2 0 0 2 2 2 1 Cid1 family poly A polymerase tRNA_NucTransf2 PF09249.11 ETO32955.1 - 0.0045 17.2 0.0 0.54 10.5 0.0 2.6 1 1 0 1 1 1 1 tRNA nucleotidyltransferase, second domain Apis_Csd PF11671.8 ETO32955.1 - 4.2 7.4 10.9 13 5.7 5.5 3.3 3 1 1 4 4 4 0 Complementary sex determiner protein DHC_N1 PF08385.12 ETO32956.1 - 0.0077 14.9 0.4 0.011 14.4 0.4 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Syntaxin_2 PF14523.6 ETO32956.1 - 0.074 13.4 0.1 0.074 13.4 0.1 2.5 3 0 0 3 3 3 0 Syntaxin-like protein MAP70 PF07058.11 ETO32956.1 - 7.2 5.2 5.3 10 4.7 5.3 1.1 1 0 0 1 1 1 0 Microtubule-associated protein 70 DEAD PF00270.29 ETO32957.1 - 2e-40 138.4 0.0 3.3e-40 137.7 0.0 1.3 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO32957.1 - 3.4e-07 30.4 0.0 9.2e-07 29.0 0.0 1.6 2 0 0 2 2 2 1 Type III restriction enzyme, res subunit CMS1 PF14617.6 ETO32957.1 - 0.00027 20.4 0.0 0.00048 19.5 0.0 1.3 1 0 0 1 1 1 1 U3-containing 90S pre-ribosomal complex subunit SecA_DEAD PF07517.14 ETO32957.1 - 0.018 14.3 0.0 0.036 13.4 0.0 1.4 1 0 0 1 1 1 0 SecA DEAD-like domain DUF5580 PF17743.1 ETO32958.1 - 0.069 11.7 1.5 0.096 11.2 1.5 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5580) bZIP_1 PF00170.21 ETO32959.1 - 0.022 14.8 1.0 0.051 13.7 1.0 1.6 1 0 0 1 1 1 0 bZIP transcription factor ZZ PF00569.17 ETO32960.1 - 3.8e-13 49.0 7.3 3.8e-13 49.0 7.3 3.0 3 0 0 3 3 3 2 Zinc finger, ZZ type Hormone_4 PF00220.17 ETO32961.1 - 0.052 13.5 0.5 0.13 12.3 0.5 1.7 1 0 0 1 1 1 0 Neurohypophysial hormones, N-terminal Domain ATP-synt_ab PF00006.25 ETO32962.1 - 3.8e-49 167.2 0.0 5e-49 166.8 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain ATP-synt_ab_N PF02874.23 ETO32963.1 - 7.5e-16 58.4 0.2 1.3e-15 57.6 0.2 1.4 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain ATP-synt_ab PF00006.25 ETO32963.1 - 9.2e-07 28.7 0.0 1.4e-06 28.1 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, nucleotide-binding domain Pro_sub2 PF18513.1 ETO32966.1 - 0.027 14.6 1.3 0.068 13.4 1.3 1.7 1 0 0 1 1 1 0 Prodomain subtilisin 2 WD40_alt PF14077.6 ETO32966.1 - 0.047 13.6 0.4 0.52 10.2 0.1 2.3 2 0 0 2 2 2 0 Alternative WD40 repeat motif CENP-N PF05238.13 ETO32968.1 - 0.04 13.2 3.5 0.049 12.9 3.5 1.3 1 0 0 1 1 1 0 Kinetochore protein CHL4 like Arabino_trans_C PF14896.6 ETO32968.1 - 0.18 10.8 5.7 0.18 10.7 4.4 1.7 2 0 0 2 2 2 0 EmbC C-terminal domain RR_TM4-6 PF06459.12 ETO32968.1 - 1.2 8.9 11.7 2 8.2 11.7 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AFT PF08731.11 ETO32968.1 - 2 8.9 7.2 2.2 8.7 5.3 1.9 2 0 0 2 2 2 0 Transcription factor AFT Connexin PF00029.19 ETO32968.1 - 7.8 6.2 7.5 15 5.2 7.5 1.4 1 0 0 1 1 1 0 Connexin Kelch_1 PF01344.25 ETO32969.1 - 3.1e-07 29.9 0.2 0.00078 19.0 0.2 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO32969.1 - 7.6e-06 25.7 0.2 0.017 15.1 0.1 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO32969.1 - 1.2e-05 25.2 0.0 0.025 14.6 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO32969.1 - 2.8e-05 24.2 0.1 0.13 12.6 0.1 2.8 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO32969.1 - 0.0086 16.0 0.3 3.9 7.6 0.2 2.5 2 0 0 2 2 2 2 Kelch motif WD40 PF00400.32 ETO32970.1 - 8.2e-41 137.2 8.5 2.3e-10 40.9 0.1 4.0 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32970.1 - 1.8e-18 66.6 0.4 3.2e-05 24.1 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO32970.1 - 1.9e-10 40.2 0.1 0.035 13.1 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO32970.1 - 4.8e-08 32.7 1.1 0.00021 20.8 0.1 2.7 1 1 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO32970.1 - 3.1e-07 29.4 0.3 0.13 10.9 0.0 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO32970.1 - 8.4e-07 29.0 0.2 0.0065 16.4 0.1 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO32970.1 - 6.1e-05 22.8 1.1 5.1 7.2 0.0 4.1 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO32970.1 - 0.0028 17.7 0.2 0.29 11.2 0.1 2.6 1 1 2 3 3 3 1 Family of unknown function (DUF5474) DUF5570 PF17731.1 ETO32970.1 - 0.0092 16.1 0.3 3.5 7.7 0.0 2.8 1 1 2 3 3 3 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO32970.1 - 0.015 14.6 0.1 0.081 12.2 0.1 2.0 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ETO32970.1 - 0.057 12.3 0.9 2.6 6.9 0.0 2.7 2 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF4221 PF13970.6 ETO32970.1 - 0.059 12.9 0.2 1.7 8.1 0.0 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Phage_CI_repr PF07022.13 ETO32970.1 - 0.076 13.1 0.2 1.9 8.7 0.2 2.2 2 1 0 2 2 2 0 Bacteriophage CI repressor helix-turn-helix domain Cytochrom_D1 PF02239.16 ETO32970.1 - 0.11 10.9 0.0 1.3 7.5 0.0 2.0 1 1 1 2 2 2 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO32970.1 - 0.88 9.3 2.6 38 4.1 0.1 3.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO32971.1 - 1.8e-05 25.4 3.3 7.2e-05 23.5 3.3 2.1 2 1 0 2 2 2 1 WD domain, G-beta repeat Ank_2 PF12796.7 ETO32972.1 - 0.021 15.4 0.0 1.2 9.7 0.0 3.0 2 1 0 2 2 2 0 Ankyrin repeats (3 copies) TMEM208_SND2 PF05620.11 ETO32973.1 - 0.059 13.1 1.0 0.083 12.7 0.1 1.6 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 WD40 PF00400.32 ETO32974.1 - 8.5e-46 153.0 28.9 2.1e-07 31.5 0.3 8.0 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32974.1 - 3.8e-12 46.4 1.1 0.048 14.0 0.1 5.5 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO32974.1 - 3.5e-07 29.2 4.6 3.3 6.2 0.0 5.8 1 1 4 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO32974.1 - 3e-05 24.0 3.7 0.044 13.7 0.2 3.5 2 2 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A zf-TRAF PF02176.18 ETO32974.1 - 5.3e-05 23.8 2.2 5.3e-05 23.8 2.2 2.5 3 0 0 3 3 3 1 TRAF-type zinc finger WD40_like PF17005.5 ETO32974.1 - 0.0011 18.3 1.1 1.7 7.9 0.0 3.8 3 1 0 4 4 4 2 WD40-like domain zf-C2H2_6 PF13912.6 ETO32974.1 - 0.0056 16.6 0.3 0.43 10.6 0.0 2.9 2 0 0 2 2 2 1 C2H2-type zinc finger Exonuc_VII_L PF02601.15 ETO32974.1 - 0.85 9.1 9.3 1.3 8.5 9.3 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit WD40 PF00400.32 ETO32975.1 - 1.5e-69 228.2 14.8 4.2e-10 40.0 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO32975.1 - 3.9e-28 97.6 5.1 0.00043 20.5 0.1 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO32975.1 - 5.4e-14 52.2 5.1 0.00013 21.4 0.5 4.6 2 1 3 5 5 5 4 WD40-like domain Ge1_WD40 PF16529.5 ETO32975.1 - 7e-14 51.5 1.1 0.0013 17.7 0.0 6.2 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO32975.1 - 3.7e-13 49.8 4.7 3.5e-05 23.8 0.3 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO32975.1 - 1.4e-07 30.6 5.3 0.078 11.6 0.2 5.0 1 1 4 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO32975.1 - 3.2e-06 25.9 0.3 0.0042 15.7 0.1 2.6 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO32975.1 - 1.2e-05 25.3 3.0 11 6.2 0.0 5.4 1 1 5 6 6 6 1 Family of unknown function (DUF5570) VID27 PF08553.10 ETO32975.1 - 0.00018 20.7 1.0 0.0011 18.1 0.3 2.3 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO32975.1 - 0.00044 20.1 7.0 2.6 8.1 0.1 6.0 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO32975.1 - 0.00091 18.2 3.9 1.2 8.0 0.0 4.7 1 1 3 5 5 5 2 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO32975.1 - 0.0036 16.7 0.4 1.9 7.7 0.0 3.5 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DUF4999 PF16390.5 ETO32975.1 - 0.022 15.0 5.3 18 5.6 0.0 4.7 5 1 0 5 5 5 0 Domain of unknown function RicinB_lectin_2 PF14200.6 ETO32975.1 - 0.072 13.8 3.3 1.2 9.9 0.2 2.7 2 1 0 2 2 2 0 Ricin-type beta-trefoil lectin domain-like Proteasome_A_N PF10584.9 ETO32975.1 - 6.1 6.6 6.4 34 4.3 0.0 4.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature RST PF12174.8 ETO32976.1 - 0.46 10.4 0.0 0.46 10.4 0.0 2.9 4 0 0 4 4 4 0 RCD1-SRO-TAF4 (RST) plant domain Na_Ca_ex PF01699.24 ETO32978.1 - 3.5e-11 43.3 5.5 4.2e-11 43.0 5.5 1.1 1 0 0 1 1 1 1 Sodium/calcium exchanger protein Lipase_bact_N PF12262.8 ETO32978.1 - 0.077 12.3 0.0 0.086 12.2 0.0 1.1 1 0 0 1 1 1 0 Bacterial virulence factor lipase N-terminal Iron_permease PF04120.12 ETO32978.1 - 0.49 10.2 5.7 0.68 9.7 5.2 1.5 1 1 0 1 1 1 0 Low affinity iron permease RNase_PH_C PF03725.15 ETO32979.1 - 9.4e-11 41.6 0.0 1.8e-10 40.7 0.0 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 2 DUF2838 PF10998.8 ETO32980.1 - 1.1e-32 112.6 8.2 1.1e-32 112.6 8.2 2.1 2 1 1 3 3 3 1 Protein of unknown function (DUF2838) Kelch_6 PF13964.6 ETO32981.1 - 2.5e-07 30.7 0.8 0.082 13.2 0.0 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO32981.1 - 1.2e-06 28.0 0.4 0.0028 17.2 0.0 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO32981.1 - 5.7e-06 26.2 1.7 2.2 8.4 0.0 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO32981.1 - 5.4e-05 23.0 1.6 0.44 10.6 0.0 4.8 6 0 0 6 6 6 2 Kelch motif Kelch_4 PF13418.6 ETO32981.1 - 7.5e-05 22.7 0.1 0.00071 19.5 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO32981.1 - 0.00024 21.3 0.1 0.17 12.2 0.0 4.2 6 0 0 6 6 6 1 Galactose oxidase, central domain DUF5128 PF17170.4 ETO32981.1 - 0.0045 16.2 0.4 0.0045 16.2 0.4 1.6 2 0 0 2 2 2 1 6-bladed beta-propeller EF-hand_7 PF13499.6 ETO32982.1 - 1.5e-06 28.5 3.8 1.3e-05 25.6 0.1 2.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO32982.1 - 1.7e-06 27.5 3.7 0.26 11.3 0.0 4.1 3 1 1 4 4 4 2 EF-hand domain EF-hand_1 PF00036.32 ETO32982.1 - 2.4e-05 23.6 2.7 1.5 8.5 0.0 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ETO32982.1 - 0.036 13.9 0.8 2.9 7.8 0.1 2.5 2 1 0 2 2 2 0 EF-hand domain pair DUF1281 PF06924.11 ETO32982.1 - 0.045 13.3 0.0 0.06 12.9 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1281) EF-hand_14 PF17959.1 ETO32982.1 - 0.058 13.8 1.6 0.68 10.3 0.2 2.5 1 1 1 2 2 2 0 EF-hand domain SPC25 PF06703.11 ETO32982.1 - 0.08 12.7 0.2 0.11 12.3 0.2 1.2 1 0 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) RPT PF13446.6 ETO32982.1 - 0.085 12.8 0.3 0.2 11.6 0.0 1.9 2 1 0 2 2 2 0 A repeated domain in UCH-protein GPHH PF16905.5 ETO32982.1 - 0.16 11.8 0.0 22 4.9 0.0 2.4 2 0 0 2 2 2 0 Voltage-dependent L-type calcium channel, IQ-associated Peptidase_C14 PF00656.22 ETO32983.1 - 1.3e-14 54.7 1.7 2.6e-14 53.8 0.4 2.2 2 0 0 2 2 2 1 Caspase domain Kelch_1 PF01344.25 ETO32983.1 - 2.3e-07 30.3 1.8 0.00098 18.7 0.1 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO32983.1 - 1.2e-06 28.3 0.3 0.065 13.3 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO32983.1 - 0.12 12.4 5.5 3.7 7.7 0.1 4.1 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO32984.1 - 0.089 13.7 0.0 0.089 13.7 0.0 4.9 6 0 0 6 6 6 0 WD domain, G-beta repeat Clathrin PF00637.20 ETO32986.1 - 1.7e-13 50.6 5.6 1.1e-12 48.0 1.0 3.1 2 1 1 3 3 3 1 Region in Clathrin and VPS PPR_2 PF13041.6 ETO32986.1 - 0.026 14.7 0.1 16 5.7 0.0 4.1 4 0 0 4 4 4 0 PPR repeat family PPR PF01535.20 ETO32986.1 - 0.095 13.0 0.3 1e+02 3.5 0.0 4.1 4 0 0 4 4 4 0 PPR repeat TPR_19 PF14559.6 ETO32986.1 - 0.11 13.0 0.1 4.2 7.9 0.0 3.2 4 0 0 4 4 4 0 Tetratricopeptide repeat MA3 PF02847.17 ETO32986.1 - 0.8 9.7 0.0 0.8 9.7 0.0 3.4 5 0 0 5 5 5 0 MA3 domain PBP1_TM PF14812.6 ETO32986.1 - 0.92 9.9 8.3 3.6 8.0 8.3 2.0 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Glyco_hydro_30 PF02055.16 ETO32987.1 - 9.4e-28 97.2 0.1 1.2e-27 96.8 0.1 1.1 1 0 0 1 1 1 1 Glycosyl hydrolase family 30 TIM-barrel domain Glyco_hydro_30C PF17189.4 ETO32987.1 - 1.1e-05 25.6 0.4 3.5e-05 23.9 0.4 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 30 beta sandwich domain BRCT_2 PF16589.5 ETO32988.1 - 8.1e-09 35.8 0.1 1.6e-08 34.9 0.1 1.5 1 0 0 1 1 1 1 BRCT domain, a BRCA1 C-terminus domain BRCT PF00533.26 ETO32988.1 - 0.01 16.2 0.1 0.023 15.0 0.1 1.7 1 1 0 1 1 1 0 BRCA1 C Terminus (BRCT) domain Pox_H7 PF04787.12 ETO32988.1 - 0.051 14.1 0.1 0.074 13.6 0.1 1.2 1 0 0 1 1 1 0 Late protein H7 Cofilin_ADF PF00241.20 ETO32989.1 - 4.7e-05 23.2 1.3 0.0021 17.9 1.3 2.4 1 1 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein LRR_9 PF14580.6 ETO32990.1 - 6e-10 38.9 3.6 3.3e-09 36.5 3.5 2.0 1 1 0 1 1 1 1 Leucine-rich repeat LRR_4 PF12799.7 ETO32990.1 - 7.1e-08 32.6 6.7 5.3e-05 23.5 1.1 2.9 2 1 1 3 3 3 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO32990.1 - 6.3e-06 25.9 3.4 0.0011 18.7 0.1 3.0 2 1 1 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 ETO32990.1 - 3.8 7.8 6.9 31 5.0 0.0 3.8 5 0 0 5 5 5 0 Leucine Rich repeat Ribosomal_L18A PF01775.17 ETO32991.1 - 1.4e-42 144.6 0.8 2.2e-42 144.0 0.5 1.5 1 1 0 1 1 1 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A Thioredoxin PF00085.20 ETO32993.1 - 1.4e-25 89.3 5.0 9.6e-13 48.0 0.2 2.7 2 1 0 3 3 3 2 Thioredoxin Thioredoxin_7 PF13899.6 ETO32993.1 - 5.5e-08 32.9 0.5 0.0042 17.2 0.1 2.6 2 0 0 2 2 2 2 Thioredoxin-like Thioredoxin_2 PF13098.6 ETO32993.1 - 7.6e-06 26.3 1.9 0.059 13.8 0.1 2.8 2 1 0 2 2 2 2 Thioredoxin-like domain AhpC-TSA PF00578.21 ETO32993.1 - 1.6e-05 24.8 0.9 0.0026 17.7 0.2 2.5 2 0 0 2 2 2 2 AhpC/TSA family DDE_Tnp_1_2 PF13586.6 ETO32993.1 - 0.014 15.8 0.2 0.47 10.8 0.0 2.7 3 0 0 3 3 3 0 Transposase DDE domain RPA_C PF08784.11 ETO32993.1 - 0.027 15.1 0.2 0.052 14.2 0.2 1.5 1 0 0 1 1 1 0 Replication protein A C terminal Thioredoxin_8 PF13905.6 ETO32993.1 - 0.048 14.0 2.8 10 6.5 0.1 3.1 3 1 0 3 3 3 0 Thioredoxin-like Redoxin PF08534.10 ETO32993.1 - 0.1 12.3 0.1 0.81 9.4 0.0 2.4 2 0 0 2 2 2 0 Redoxin SM-ATX PF14438.6 ETO32995.1 - 0.14 12.3 0.7 3.1 8.0 0.1 2.5 2 0 0 2 2 2 0 Ataxin 2 SM domain RGS_DHEX PF18148.1 ETO32995.1 - 0.17 12.0 0.1 0.17 12.0 0.1 3.5 3 2 2 5 5 5 0 Regulator of G-protein signalling DHEX domain OrsD PF12013.8 ETO32996.1 - 0.0036 17.7 0.2 0.0054 17.2 0.2 1.3 1 0 0 1 1 1 1 Orsellinic acid/F9775 biosynthesis cluster protein D G-alpha PF00503.20 ETO32997.1 - 2.7e-37 128.8 0.7 3e-37 128.6 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO32997.1 - 0.069 12.6 0.0 0.11 12.0 0.0 1.2 1 0 0 1 1 1 0 ADP-ribosylation factor family SLC12 PF03522.15 ETO32998.1 - 5.8e-32 111.3 6.1 2.4e-21 76.3 0.0 2.5 2 1 1 3 3 3 2 Solute carrier family 12 Cadherin_C_2 PF16492.5 ETO32998.1 - 0.092 13.5 0.1 0.43 11.4 0.1 2.3 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal SHR-BD PF06650.12 ETO32999.1 - 2e-09 37.3 0.7 7.6e-09 35.3 0.1 1.9 1 1 1 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 AAA_9 PF12781.7 ETO33001.1 - 7.1e-77 257.5 9.5 5.5e-49 166.3 2.9 3.7 4 0 0 4 4 4 3 ATP-binding dynein motor region Dynein_C PF18199.1 ETO33001.1 - 1.3e-75 254.4 0.0 3.2e-75 253.2 0.0 1.6 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain AAA_lid_11 PF18198.1 ETO33001.1 - 2.1e-52 177.2 0.0 4.2e-52 176.3 0.0 1.5 1 0 0 1 1 1 1 Dynein heavy chain AAA lid domain Dynein_heavy PF03028.15 ETO33001.1 - 3.1e-50 169.2 0.1 2.6e-45 153.3 0.1 3.2 3 1 0 3 3 3 2 Dynein heavy chain region D6 P-loop domain AAA_8 PF12780.7 ETO33002.1 - 1.4e-99 332.7 8.6 1.9e-80 269.9 0.0 3.7 4 0 0 4 4 4 2 P-loop containing dynein motor region D4 AAA_7 PF12775.7 ETO33002.1 - 2.4e-68 229.2 0.0 5.5e-68 228.0 0.0 1.7 1 0 0 1 1 1 1 P-loop containing dynein motor region MT PF12777.7 ETO33002.1 - 3.7e-51 174.2 8.3 6.4e-51 173.4 8.3 1.3 1 0 0 1 1 1 1 Microtubule-binding stalk of dynein motor Dynein_AAA_lid PF17852.1 ETO33002.1 - 7.2e-39 132.8 1.1 2.7e-38 131.0 0.2 2.6 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA_lid_1 PF17857.1 ETO33002.1 - 1.1e-21 76.9 0.1 4.9e-21 74.8 0.1 2.2 1 0 0 1 1 1 1 AAA+ lid domain AAA_5 PF07728.14 ETO33002.1 - 2e-11 44.1 0.0 3.8e-09 36.7 0.0 2.8 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) Herpes_U30 PF04523.13 ETO33002.1 - 0.00095 17.2 0.4 0.0022 16.0 0.4 1.5 1 0 0 1 1 1 1 Herpes virus tegument protein U30 DHR10 PF18595.1 ETO33002.1 - 0.0034 17.4 6.3 0.0034 17.4 6.3 3.5 2 1 1 3 3 3 1 Designed helical repeat protein 10 domain Sigma54_activat PF00158.26 ETO33002.1 - 0.004 16.9 0.0 0.015 15.0 0.0 2.0 2 0 0 2 2 1 1 Sigma-54 interaction domain T2SSE PF00437.20 ETO33002.1 - 0.01 14.9 0.0 0.033 13.3 0.0 1.8 2 0 0 2 2 2 0 Type II/IV secretion system protein DUF815 PF05673.13 ETO33002.1 - 0.025 13.7 0.0 0.72 9.0 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF815) ERM PF00769.19 ETO33002.1 - 0.035 13.9 15.6 0.48 10.2 6.7 2.6 2 0 0 2 2 2 0 Ezrin/radixin/moesin family COG2 PF06148.11 ETO33002.1 - 0.039 14.0 14.0 0.17 12.0 1.4 3.5 2 1 0 2 2 2 0 COG (conserved oligomeric Golgi) complex component, COG2 AAA PF00004.29 ETO33002.1 - 0.044 14.2 0.0 1.5 9.2 0.0 3.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO33002.1 - 0.055 13.8 0.0 0.35 11.1 0.0 2.4 1 0 0 1 1 1 0 AAA domain ResIII PF04851.15 ETO33002.1 - 0.087 12.8 0.1 0.087 12.8 0.1 3.1 4 0 0 4 4 3 0 Type III restriction enzyme, res subunit DUF724 PF05266.14 ETO33002.1 - 0.11 12.3 12.1 3.6 7.4 0.2 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF724) CCDC144C PF14915.6 ETO33002.1 - 0.13 11.4 20.4 0.15 11.1 2.8 2.4 2 0 0 2 2 2 0 CCDC144C protein coiled-coil region SesA PF17107.5 ETO33002.1 - 0.19 11.9 7.0 0.57 10.4 0.1 3.4 2 0 0 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases Spc7 PF08317.11 ETO33002.1 - 0.21 10.4 17.1 0.17 10.7 0.8 2.4 2 0 0 2 2 2 0 Spc7 kinetochore protein Bul1_C PF04426.12 ETO33002.1 - 0.31 10.4 7.3 0.083 12.3 2.3 2.4 2 0 0 2 2 2 0 Bul1 C terminus Tropomyosin PF00261.20 ETO33002.1 - 0.4 10.0 24.0 0.2 11.0 5.1 2.9 2 0 0 2 2 2 0 Tropomyosin Fez1 PF06818.15 ETO33002.1 - 0.99 9.8 17.0 0.54 10.7 4.1 3.5 4 0 0 4 4 3 0 Fez1 Phage_HK97_TLTM PF06120.11 ETO33002.1 - 1.1 8.3 11.8 1.6 7.9 0.1 2.3 2 0 0 2 2 2 0 Tail length tape measure protein Exonuc_VII_L PF02601.15 ETO33002.1 - 1.3 8.6 14.8 1.7 8.1 0.5 2.7 3 0 0 3 3 3 0 Exonuclease VII, large subunit AAA_16 PF13191.6 ETO33002.1 - 1.3 9.4 0.0 1.3 9.4 0.0 3.6 5 1 1 6 6 3 0 AAA ATPase domain Cob_adeno_trans PF01923.18 ETO33002.1 - 2.1 8.4 9.2 10 6.2 2.1 3.4 4 0 0 4 4 3 0 Cobalamin adenosyltransferase Golgin_A5 PF09787.9 ETO33002.1 - 4.2 6.7 16.9 2.1 7.8 0.7 2.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 Fib_alpha PF08702.10 ETO33002.1 - 5.8 7.1 8.4 23 5.2 2.5 3.2 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family DUF4407 PF14362.6 ETO33002.1 - 6.1 6.1 12.3 2.1 7.6 0.6 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) Lebercilin PF15619.6 ETO33002.1 - 7.4 6.2 20.9 2 8.1 3.2 2.6 2 0 0 2 2 2 0 Ciliary protein causing Leber congenital amaurosis disease NPV_P10 PF05531.12 ETO33002.1 - 8.1 7.0 6.9 29 5.2 1.2 3.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein ATG16 PF08614.11 ETO33002.1 - 8.1 6.6 26.2 0.92 9.7 7.0 2.9 3 0 0 3 3 2 0 Autophagy protein 16 (ATG16) TPR_MLP1_2 PF07926.12 ETO33002.1 - 9.3 6.3 25.7 0.045 13.8 1.8 3.2 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein COesterase PF00135.28 ETO33003.1 - 1.5e-58 199.0 2.1 1e-56 192.9 2.1 2.2 1 1 0 1 1 1 1 Carboxylesterase family PhyH PF05721.13 ETO33004.1 - 5.6e-08 33.3 0.0 1.1e-07 32.3 0.0 1.6 1 1 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) DUF1479 PF07350.12 ETO33004.1 - 6e-08 31.9 0.5 7.4e-05 21.7 0.1 2.7 1 1 0 2 2 2 2 Protein of unknown function (DUF1479) Elongin_A PF06881.11 ETO33004.1 - 0.28 11.7 9.6 0.71 10.4 9.6 1.6 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A DUF4407 PF14362.6 ETO33004.1 - 0.85 8.9 3.3 1.2 8.4 3.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4065 PF13274.6 ETO33004.1 - 1.1 10.2 7.0 1.2 10.1 4.5 2.4 2 1 0 2 2 2 0 Protein of unknown function (DUF4065) Band_3_cyto PF07565.13 ETO33004.1 - 1.1 9.0 4.9 1.7 8.4 4.9 1.3 1 0 0 1 1 1 0 Band 3 cytoplasmic domain MDFI PF15316.6 ETO33004.1 - 3.8 7.6 6.3 6.5 6.8 6.3 1.3 1 0 0 1 1 1 0 MyoD family inhibitor Pro_isomerase PF00160.21 ETO33005.1 - 1.8e-14 54.3 0.0 2.7e-14 53.8 0.0 1.2 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD GIT_SHD PF08518.11 ETO33005.1 - 0.19 11.4 0.6 23 4.7 0.0 2.6 2 0 0 2 2 2 0 Spa2 homology domain (SHD) of GIT G-alpha PF00503.20 ETO33006.1 - 3.8e-09 36.2 0.1 4.1e-09 36.1 0.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit RsgA_GTPase PF03193.16 ETO33006.1 - 5.3e-05 23.2 0.0 5.8e-05 23.1 0.0 1.2 1 0 0 1 1 1 1 RsgA GTPase ABC_tran PF00005.27 ETO33006.1 - 0.0005 20.6 0.1 0.00065 20.2 0.1 1.4 1 1 0 1 1 1 1 ABC transporter Rad17 PF03215.15 ETO33006.1 - 0.00055 19.9 0.0 0.00074 19.5 0.0 1.2 1 0 0 1 1 1 1 Rad17 P-loop domain RNA_helicase PF00910.22 ETO33006.1 - 0.00056 20.3 0.0 0.00079 19.8 0.0 1.3 1 0 0 1 1 1 1 RNA helicase AAA_16 PF13191.6 ETO33006.1 - 0.00091 19.7 0.0 0.0011 19.4 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain PduV-EutP PF10662.9 ETO33006.1 - 0.0027 17.5 0.2 0.0098 15.6 0.1 1.8 1 1 1 2 2 2 1 Ethanolamine utilisation - propanediol utilisation AAA_18 PF13238.6 ETO33006.1 - 0.0028 18.2 0.0 0.0039 17.7 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETO33006.1 - 0.0036 17.5 0.0 0.0049 17.1 0.0 1.3 1 0 0 1 1 1 1 AAA domain NB-ARC PF00931.22 ETO33006.1 - 0.0067 15.6 0.1 0.0087 15.3 0.1 1.3 1 1 0 1 1 1 1 NB-ARC domain AAA_7 PF12775.7 ETO33006.1 - 0.0098 15.4 0.0 0.015 14.9 0.0 1.5 1 1 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO33006.1 - 0.011 16.1 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Roc PF08477.13 ETO33006.1 - 0.013 15.7 0.0 0.018 15.2 0.0 1.3 1 0 0 1 1 1 0 Ras of Complex, Roc, domain of DAPkinase DUF815 PF05673.13 ETO33006.1 - 0.024 13.8 0.0 0.027 13.7 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF815) AAA_22 PF13401.6 ETO33006.1 - 0.029 14.6 0.1 0.047 14.0 0.1 1.4 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ETO33006.1 - 0.034 14.0 0.0 0.036 14.0 0.0 1.2 1 0 0 1 1 1 0 ATPase domain predominantly from Archaea Mg_chelatase PF01078.21 ETO33006.1 - 0.043 13.2 0.0 0.067 12.6 0.0 1.3 1 1 0 1 1 1 0 Magnesium chelatase, subunit ChlI NACHT PF05729.12 ETO33006.1 - 0.045 13.7 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 NACHT domain AAA_29 PF13555.6 ETO33006.1 - 0.048 13.4 0.1 0.077 12.8 0.1 1.3 1 0 0 1 1 1 0 P-loop containing region of AAA domain SRPRB PF09439.10 ETO33006.1 - 0.048 13.1 0.1 0.06 12.8 0.1 1.4 1 1 0 1 1 1 0 Signal recognition particle receptor beta subunit AAA_33 PF13671.6 ETO33006.1 - 0.063 13.4 0.0 0.08 13.1 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO33006.1 - 0.068 13.7 0.2 0.098 13.1 0.2 1.4 1 1 0 1 1 1 0 AAA domain AAA_PrkA PF08298.11 ETO33006.1 - 0.085 11.8 0.0 0.12 11.3 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain AAA_5 PF07728.14 ETO33006.1 - 0.096 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) MCM PF00493.23 ETO33006.1 - 0.097 11.8 0.0 0.14 11.2 0.0 1.3 1 0 0 1 1 1 0 MCM P-loop domain PRK PF00485.18 ETO33006.1 - 0.14 11.9 0.0 0.2 11.3 0.0 1.3 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family Zeta_toxin PF06414.12 ETO33006.1 - 0.14 11.4 0.0 0.22 10.8 0.0 1.2 1 0 0 1 1 1 0 Zeta toxin WD40 PF00400.32 ETO33007.1 - 7e-40 134.3 25.6 1.9e-06 28.5 0.6 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33007.1 - 7.1e-12 45.5 0.5 3 8.2 0.0 6.1 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33007.1 - 2.4e-09 36.4 5.6 0.68 8.5 0.0 6.0 2 2 3 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33007.1 - 1.4e-05 24.6 4.7 0.018 14.4 0.1 4.2 2 2 2 4 4 4 3 WD40-like domain WD40 PF00400.32 ETO33008.1 - 3.1e-43 144.9 34.0 3.8e-08 33.9 1.1 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33008.1 - 1.1e-12 48.1 4.3 0.018 15.3 0.0 6.0 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33008.1 - 4.7e-11 42.0 6.9 0.01 14.5 0.1 5.4 4 2 0 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33008.1 - 4.7e-05 22.8 4.1 0.69 9.2 0.6 4.6 2 2 3 5 5 5 3 WD40-like domain SH3_13 PF18335.1 ETO33008.1 - 0.0029 17.4 0.2 0.035 13.9 0.1 2.5 3 0 0 3 3 3 1 ATP-dependent RecD-like DNA helicase SH3 domain WD40 PF00400.32 ETO33009.1 - 1.3e-06 29.0 6.7 0.013 16.3 0.1 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 ETO33010.1 - 2e-18 66.4 21.4 2.1e-05 25.2 0.6 5.8 5 2 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33010.1 - 6.1e-05 23.2 1.4 0.23 11.8 0.0 4.1 2 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33010.1 - 0.00035 19.3 4.3 0.38 9.3 0.1 3.3 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO33011.1 - 1.8e-14 53.9 2.0 4.2e-05 24.2 0.0 4.0 3 2 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33011.1 - 0.0072 15.0 0.1 0.1 11.2 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 SprB PF13573.6 ETO33011.1 - 0.98 9.2 4.9 6.3 6.7 0.4 2.8 2 1 0 2 2 2 0 SprB repeat Ank_5 PF13857.6 ETO33012.1 - 0.011 16.1 1.4 0.37 11.2 0.0 3.2 3 1 1 4 4 4 0 Ankyrin repeats (many copies) FRG PF08867.11 ETO33012.1 - 0.017 16.1 4.4 0.08 13.9 0.4 2.3 2 0 0 2 2 2 0 FRG domain RGI_lyase PF18370.1 ETO33012.1 - 0.023 15.0 1.1 3 8.2 0.1 3.2 1 1 1 2 2 2 0 Rhamnogalacturonan I lyases beta-sheet domain DUF4611 PF15387.6 ETO33012.1 - 5 7.4 16.7 0.43 10.8 0.5 2.9 3 1 0 3 3 3 0 Domain of unknown function (DUF4611) BTB PF00651.31 ETO33013.1 - 2.3e-15 56.8 0.1 3.8e-15 56.1 0.1 1.3 1 1 0 1 1 1 1 BTB/POZ domain DRIM PF07539.12 ETO33013.1 - 0.0083 14.5 0.0 0.011 14.0 0.0 1.2 1 0 0 1 1 1 1 Down-regulated in metastasis DUF2487 PF10673.9 ETO33013.1 - 0.11 12.5 0.0 0.18 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2487) VWD PF00094.25 ETO33014.1 - 5.9e-07 29.9 2.5 1.9e-06 28.2 2.5 1.9 1 1 0 1 1 1 1 von Willebrand factor type D domain EGF PF00008.27 ETO33014.1 - 0.0019 18.5 5.3 0.0019 18.5 5.3 3.2 3 0 0 3 3 3 1 EGF-like domain hEGF PF12661.7 ETO33014.1 - 0.012 16.2 3.3 0.012 16.2 3.3 3.5 3 0 0 3 3 3 0 Human growth factor-like EGF LKAAEAR PF15478.6 ETO33019.1 - 0.073 13.3 0.6 0.2 11.9 0.6 1.7 1 0 0 1 1 1 0 Family of unknown function with LKAAEAR motif CopK PF11525.8 ETO33019.1 - 0.13 11.9 2.0 0.3 10.8 2.0 1.6 1 0 0 1 1 1 0 Copper resistance protein K Zip PF02535.22 ETO33019.1 - 0.57 9.4 1.5 0.93 8.6 1.5 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Menin PF05053.13 ETO33019.1 - 8.8 4.5 13.7 0.78 8.0 8.1 1.8 2 0 0 2 2 2 0 Menin DEP PF00610.21 ETO33020.1 - 3.6e-15 55.8 0.3 6.1e-15 55.0 0.3 1.4 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) PSD4 PF07631.11 ETO33022.1 - 0.087 13.4 0.5 0.14 12.7 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1592) SLIDE PF09111.10 ETO33022.1 - 0.18 11.8 4.8 0.15 12.1 3.5 1.5 1 1 0 1 1 1 0 SLIDE Toxin_18 PF08087.11 ETO33023.1 - 0.12 12.3 0.1 0.32 11.0 0.1 1.6 1 0 0 1 1 1 0 Conotoxin O-superfamily DUF4604 PF15377.6 ETO33023.1 - 0.14 12.6 26.6 0.27 11.7 26.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4604) YL1 PF05764.13 ETO33023.1 - 0.19 11.8 25.7 0.32 11.1 25.7 1.3 1 0 0 1 1 1 0 YL1 nuclear protein DUF3439 PF11921.8 ETO33023.1 - 0.91 9.5 6.6 4.4 7.3 5.7 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) CDC45 PF02724.14 ETO33023.1 - 3.8 5.7 15.4 4.5 5.4 15.4 1.1 1 0 0 1 1 1 0 CDC45-like protein XRN_M PF17846.1 ETO33023.1 - 7 5.5 14.0 8.9 5.1 14.0 1.2 1 0 0 1 1 1 0 Xrn1 helical domain Ku_C PF03730.14 ETO33023.1 - 8.5 7.2 19.8 3.9 8.2 9.4 2.6 2 0 0 2 2 2 0 Ku70/Ku80 C-terminal arm U-box PF04564.15 ETO33024.1 - 1.8e-18 66.5 2.3 1.2e-17 63.8 0.1 3.1 2 0 0 2 2 2 1 U-box domain zf-NOSIP PF15906.5 ETO33024.1 - 0.017 15.2 1.7 0.021 14.9 0.0 2.1 3 0 0 3 3 3 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETO33024.1 - 0.055 13.3 0.3 0.055 13.3 0.3 2.2 2 0 0 2 2 2 0 Zinc-finger of the MIZ type in Nse subunit OAD_gamma PF04277.13 ETO33024.1 - 1.8 9.2 0.0 1.8 9.2 0.0 4.3 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain TPR_12 PF13424.6 ETO33025.1 - 8.3e-49 163.8 2.6 4.6e-15 55.7 0.1 4.5 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33025.1 - 2.7e-34 116.1 0.9 5.6e-09 35.6 0.5 6.7 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33025.1 - 1.3e-30 103.9 32.4 4.4e-06 26.3 1.2 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33025.1 - 5.4e-29 98.1 4.7 2.7e-05 23.9 0.1 6.7 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33025.1 - 3e-23 80.1 24.5 0.00042 20.3 0.5 6.8 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33025.1 - 8.8e-22 75.4 25.6 7.6e-05 22.5 0.1 6.9 7 0 0 7 7 6 6 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33025.1 - 1.3e-08 35.0 4.6 0.051 14.2 0.0 5.7 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33025.1 - 1.5e-07 31.0 20.9 0.077 12.7 0.1 6.5 5 2 2 7 7 7 3 TPR repeat TPR_17 PF13431.6 ETO33025.1 - 1.9e-05 24.7 13.3 0.19 12.2 0.4 5.8 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO33025.1 - 6e-05 22.6 0.1 0.042 13.2 0.1 2.8 1 1 2 3 3 3 1 MalT-like TPR region TPR_14 PF13428.6 ETO33025.1 - 0.00014 22.3 0.1 56 5.0 0.1 5.7 5 1 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33025.1 - 0.00043 20.9 0.2 7.7 7.3 0.0 4.7 4 1 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO33025.1 - 0.00084 18.7 0.9 0.046 13.2 0.1 3.7 4 0 0 4 4 4 1 SHNi-TPR TPR_3 PF07720.12 ETO33025.1 - 0.0033 17.4 17.7 0.25 11.4 0.1 5.5 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO33025.1 - 0.052 14.1 0.2 8.3 7.0 0.0 3.5 4 0 0 4 4 3 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO33025.1 - 0.14 11.6 6.0 2 7.8 0.2 3.5 3 0 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like PPR PF01535.20 ETO33025.1 - 0.98 9.8 2.9 2.3e+02 2.4 0.0 4.6 4 0 0 4 4 4 0 PPR repeat MIT PF04212.18 ETO33025.1 - 7.6 6.7 10.5 73 3.5 0.0 4.8 4 1 1 5 5 5 0 MIT (microtubule interacting and transport) domain PUB PF09409.10 ETO33027.1 - 0.056 13.4 1.5 0.12 12.3 0.1 2.4 2 1 0 2 2 2 0 PUB domain CW_binding_1 PF01473.20 ETO33027.1 - 0.72 10.3 3.9 1.2 9.6 1.1 2.9 2 0 0 2 2 2 0 Putative cell wall binding repeat MHC_II_alpha PF00993.20 ETO33028.1 - 0.052 13.2 0.1 0.14 11.9 0.1 1.7 2 0 0 2 2 2 0 Class II histocompatibility antigen, alpha domain Zip PF02535.22 ETO33030.1 - 0.18 11.0 1.0 0.18 11.0 1.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter ADH_zinc_N_2 PF13602.6 ETO33031.1 - 6.1e-16 59.7 0.0 3.7e-15 57.2 0.0 2.0 1 1 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N PF00107.26 ETO33031.1 - 1.7e-12 47.4 0.1 8.2e-12 45.2 0.1 1.9 2 0 0 2 2 2 1 Zinc-binding dehydrogenase Peptidase_S28 PF05577.12 ETO33032.1 - 5.8e-18 64.9 0.7 7.6e-18 64.5 0.7 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S28 PF05577.12 ETO33033.1 - 2.7e-23 82.5 0.3 5.3e-23 81.5 0.3 1.5 1 1 0 1 1 1 1 Serine carboxypeptidase S28 Peptidase_S37 PF05576.11 ETO33033.1 - 0.2 10.3 2.2 1.8 7.1 0.0 2.1 2 0 0 2 2 2 0 PS-10 peptidase S37 FixQ PF05545.11 ETO33034.1 - 0.12 12.4 7.3 0.31 11.0 7.3 1.7 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ DUF4834 PF16118.5 ETO33035.1 - 0.0046 17.9 0.9 0.0046 17.9 0.9 2.1 2 1 0 2 2 2 1 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO33035.1 - 0.017 13.9 1.4 0.019 13.7 1.4 1.1 1 0 0 1 1 1 0 Presenilin SID-1_RNA_chan PF13965.6 ETO33035.1 - 0.045 12.2 3.6 0.051 12.0 3.6 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 FHIPEP PF00771.20 ETO33035.1 - 0.063 11.7 0.2 0.069 11.6 0.2 1.1 1 0 0 1 1 1 0 FHIPEP family G0-G1_switch_2 PF15103.6 ETO33035.1 - 0.063 13.7 1.5 0.063 13.7 1.5 1.7 2 0 0 2 2 2 0 G0/G1 switch protein 2 Zip PF02535.22 ETO33035.1 - 0.066 12.4 0.3 0.069 12.4 0.3 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Neur_chan_memb PF02932.16 ETO33035.1 - 0.072 13.1 4.7 0.08 13.0 4.7 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region TMEM208_SND2 PF05620.11 ETO33035.1 - 0.12 12.1 6.9 0.13 12.1 5.9 1.6 1 1 0 1 1 1 0 SRP-independent targeting protein 2/TMEM208 OATP PF03137.20 ETO33035.1 - 0.13 10.5 8.4 0.028 12.7 5.2 1.4 1 1 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family RIC3 PF15361.6 ETO33035.1 - 0.16 12.3 10.1 1.8 8.9 10.1 2.3 1 1 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Mog1 PF04603.12 ETO33035.1 - 1 9.7 4.3 12 6.2 0.0 2.1 2 0 0 2 2 2 0 Ran-interacting Mog1 protein CLN3 PF02487.17 ETO33035.1 - 1.5 7.8 7.1 0.28 10.2 2.1 1.8 1 1 1 2 2 2 0 CLN3 protein DUF3464 PF11947.8 ETO33035.1 - 1.8 8.3 10.1 0.24 11.2 4.8 2.0 2 0 0 2 2 2 0 Photosynthesis affected mutant 68 Ureide_permease PF07168.11 ETO33035.1 - 2 7.0 4.1 0.57 8.9 1.2 1.5 1 1 1 2 2 2 0 Ureide permease Connexin PF00029.19 ETO33035.1 - 3.3 7.4 10.8 0.81 9.4 7.5 1.6 1 1 1 2 2 2 0 Connexin Ctr PF04145.15 ETO33035.1 - 3.4 8.3 5.3 5.7 7.5 5.3 1.6 1 1 0 1 1 1 0 Ctr copper transporter family DUF2681 PF10883.8 ETO33035.1 - 4.4 7.8 15.2 0.57 10.6 7.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) EphA2_TM PF14575.6 ETO33035.1 - 4.5 8.2 5.6 0.88 10.5 1.3 2.0 2 0 0 2 2 2 0 Ephrin type-A receptor 2 transmembrane domain AIF_C PF14721.6 ETO33035.1 - 5.6 7.3 9.8 7.8 6.9 6.1 2.0 2 0 0 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term DUF4639 PF15479.6 ETO33036.1 - 4.3 6.2 6.0 4.5 6.1 6.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) Pkinase PF00069.25 ETO33037.1 - 1.1e-70 238.1 0.8 1.6e-63 214.5 0.0 2.1 1 1 1 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33037.1 - 5e-37 127.6 0.3 1.6e-33 116.1 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase APH PF01636.23 ETO33037.1 - 0.0021 18.0 0.1 0.0062 16.5 0.2 1.6 1 1 0 1 1 1 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO33037.1 - 0.0068 15.8 0.2 0.012 14.9 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF3715 PF12509.8 ETO33038.1 - 0.016 15.2 1.3 0.024 14.6 1.3 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3715) Syntaxin PF00804.25 ETO33039.1 - 8.5e-13 48.4 8.5 8.5e-13 48.4 8.5 1.3 2 0 0 2 2 2 1 Syntaxin SNARE PF05739.19 ETO33039.1 - 4.6e-10 39.3 3.7 8.8e-10 38.4 0.3 2.4 2 0 0 2 2 2 1 SNARE domain HBM PF16591.5 ETO33039.1 - 0.0032 16.9 4.7 0.0032 16.9 4.7 2.1 2 0 0 2 2 2 1 Helical bimodular sensor domain DASH_Dam1 PF08653.10 ETO33039.1 - 0.0082 15.9 0.3 5.5 6.9 0.1 2.6 2 0 0 2 2 2 2 DASH complex subunit Dam1 DUF1877 PF08974.10 ETO33039.1 - 0.011 15.9 0.5 0.011 15.9 0.5 1.9 2 1 1 3 3 3 0 Domain of unknown function (DUF1877) DUF4757 PF15949.5 ETO33039.1 - 0.015 15.7 0.4 0.015 15.7 0.4 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4757) DUF4349 PF14257.6 ETO33039.1 - 0.016 14.7 1.6 0.016 14.7 1.6 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4349) Spectrin PF00435.21 ETO33039.1 - 0.059 13.9 6.0 2.4 8.7 0.3 2.9 2 1 0 2 2 2 0 Spectrin repeat Mod_r PF07200.13 ETO33039.1 - 0.2 11.7 9.5 1.5 8.9 4.2 3.2 2 2 0 2 2 2 0 Modifier of rudimentary (Mod(r)) protein Laminin_II PF06009.12 ETO33039.1 - 0.87 9.6 12.3 9 6.3 0.1 3.2 2 1 1 3 3 3 0 Laminin Domain II eIF3_N PF09440.10 ETO33039.1 - 6.4 7.2 10.2 9 6.7 1.6 2.9 2 2 0 2 2 2 0 eIF3 subunit 6 N terminal domain PhyH PF05721.13 ETO33040.1 - 4e-05 24.0 0.2 9e-05 22.8 0.0 1.7 2 0 0 2 2 2 1 Phytanoyl-CoA dioxygenase (PhyH) AraC_binding PF02311.19 ETO33040.1 - 0.12 12.3 0.0 0.16 11.9 0.0 1.2 1 0 0 1 1 1 0 AraC-like ligand binding domain FGF PF00167.18 ETO33041.1 - 1.4e-05 25.2 1.2 0.031 14.4 0.1 2.6 2 1 0 2 2 2 2 Fibroblast growth factor RicinB_lectin_2 PF14200.6 ETO33041.1 - 0.003 18.3 0.9 0.028 15.2 0.0 2.4 3 0 0 3 3 3 1 Ricin-type beta-trefoil lectin domain-like Fascin PF06268.13 ETO33041.1 - 0.0038 17.4 0.0 0.0087 16.3 0.0 1.7 1 0 0 1 1 1 1 Fascin domain NKAIN PF05640.14 ETO33042.1 - 0.016 14.4 8.1 0.025 13.8 8.1 1.3 1 0 0 1 1 1 0 Na,K-Atpase Interacting protein FAD_binding_8 PF08022.12 ETO33043.1 - 8.9e-26 90.1 0.0 1.6e-25 89.3 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain Ferric_reduct PF01794.19 ETO33043.1 - 2.6e-15 56.7 11.8 5.9e-15 55.5 11.8 1.7 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_6 PF00970.24 ETO33043.1 - 0.1 13.0 0.0 0.22 11.9 0.0 1.6 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain MreB_Mbl PF06723.13 ETO33044.1 - 0.073 11.9 0.0 0.1 11.4 0.0 1.1 1 0 0 1 1 1 0 MreB/Mbl protein MTTB PF06253.11 ETO33044.1 - 0.082 10.9 0.1 0.13 10.2 0.1 1.4 1 1 0 1 1 1 0 Trimethylamine methyltransferase (MTTB) Peptidase_C80 PF11713.8 ETO33044.1 - 2 8.6 5.3 3.7 7.8 0.0 3.0 2 2 0 3 3 3 0 Peptidase C80 family Kelch_6 PF13964.6 ETO33045.1 - 0.00049 20.3 3.3 0.044 14.1 0.0 4.2 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO33045.1 - 0.0094 15.5 0.1 14 5.4 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO33045.1 - 0.03 14.3 5.1 5 7.3 0.0 3.8 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO33046.1 - 1.1e-58 193.7 13.2 1e-09 38.8 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33046.1 - 8.1e-20 70.9 0.3 0.00069 19.9 0.0 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33046.1 - 4.5e-12 45.6 2.2 0.073 12.0 0.0 5.8 2 2 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33046.1 - 5.4e-10 39.1 1.3 0.0089 15.4 0.1 3.4 4 0 0 4 4 4 3 WD40-like domain PD40 PF07676.12 ETO33046.1 - 5.5e-08 32.5 5.1 0.84 9.7 0.2 6.2 7 0 0 7 7 7 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO33046.1 - 3.1e-07 29.4 2.7 0.0032 16.2 0.1 4.0 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO33046.1 - 3e-06 26.8 0.7 0.0051 16.2 0.0 3.2 1 1 2 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO33046.1 - 0.0014 17.2 0.1 3.3 6.2 0.0 2.9 1 1 2 3 3 3 1 Cytochrome D1 heme domain DUF5474 PF17568.2 ETO33046.1 - 0.0028 17.7 0.0 1.7 8.8 0.0 3.5 2 1 1 3 3 3 1 Family of unknown function (DUF5474) DUF5570 PF17731.1 ETO33046.1 - 0.011 15.8 0.7 0.57 10.3 0.0 3.2 1 1 3 4 4 4 0 Family of unknown function (DUF5570) SGL PF08450.12 ETO33046.1 - 0.02 14.5 0.3 7.8 6.0 0.0 3.1 1 1 2 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region PQQ_2 PF13360.6 ETO33046.1 - 0.038 13.6 0.2 0.09 12.3 0.1 1.7 1 1 0 1 1 1 0 PQQ-like domain TRAP-delta PF05404.12 ETO33046.1 - 0.043 13.3 0.0 0.074 12.6 0.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein, delta subunit precursor (TRAP-delta) Plk4_PB1 PF18190.1 ETO33046.1 - 0.084 13.0 0.5 35 4.6 0.0 3.3 2 1 1 3 3 3 0 Polo-like Kinase 4 Polo Box 1 WD40 PF00400.32 ETO33048.1 - 9.7e-32 108.5 21.0 7e-06 26.7 0.6 6.6 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33048.1 - 3.2e-08 33.7 1.3 0.0038 17.5 0.0 4.2 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33048.1 - 2.3e-06 27.1 3.7 0.38 10.0 0.0 4.3 3 2 1 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO33048.1 - 3.2e-06 26.1 3.0 0.069 11.8 0.2 3.9 1 1 3 4 4 4 2 Nucleoporin Nup120/160 Surfac_D-trimer PF09006.11 ETO33049.1 - 0.97 9.4 5.2 0.38 10.7 0.9 2.4 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation LPP PF04728.13 ETO33049.1 - 2.7 8.5 13.9 5.6 7.4 0.6 4.2 3 1 0 3 3 3 0 Lipoprotein leucine-zipper DUF1515 PF07439.11 ETO33049.1 - 3.4 7.7 6.8 1 9.4 1.9 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) TMEM43 PF07787.12 ETO33050.1 - 7e-08 32.2 0.3 2.3e-07 30.5 0.3 1.9 1 0 0 1 1 1 1 Transmembrane protein 43 TPR_12 PF13424.6 ETO33050.1 - 0.00012 22.3 0.2 0.00024 21.3 0.2 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TMEM43 PF07787.12 ETO33051.1 - 7.5e-08 32.1 0.9 2.4e-07 30.4 1.4 1.5 1 1 0 1 1 1 1 Transmembrane protein 43 BSP_II PF05432.11 ETO33051.1 - 0.094 12.4 17.5 0.14 11.9 17.5 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Mntp PF02659.15 ETO33051.1 - 0.15 11.8 0.0 0.4 10.4 0.0 1.7 2 0 0 2 2 2 0 Putative manganese efflux pump CDC45 PF02724.14 ETO33051.1 - 1.1 7.5 11.9 1.5 7.0 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein SPOUT_MTase PF02590.17 ETO33051.1 - 2.4 8.1 4.6 4.3 7.3 4.6 1.4 1 0 0 1 1 1 0 Predicted SPOUT methyltransferase S_100 PF01023.19 ETO33052.1 - 0.027 14.2 0.0 0.61 9.8 0.0 2.4 2 0 0 2 2 2 0 S-100/ICaBP type calcium binding domain Med30 PF11315.8 ETO33052.1 - 0.55 10.4 4.8 2.1 8.6 2.2 2.3 2 0 0 2 2 2 0 Mediator complex subunit 30 DUF2555 PF10742.9 ETO33054.1 - 0.03 14.1 0.1 0.22 11.4 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2555) Kinesin PF00225.23 ETO33057.1 - 0.0025 16.8 1.3 0.0054 15.7 1.3 1.5 1 1 0 1 1 1 1 Kinesin motor domain MIT PF04212.18 ETO33058.1 - 1.3e-09 38.0 2.7 2.4e-09 37.1 2.7 1.5 1 0 0 1 1 1 1 MIT (microtubule interacting and transport) domain AAA PF00004.29 ETO33058.1 - 0.0025 18.2 0.1 0.0068 16.8 0.1 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase PF01078.21 ETO33058.1 - 0.032 13.6 0.1 0.077 12.4 0.1 1.6 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI IstB_IS21 PF01695.17 ETO33058.1 - 0.077 12.7 0.0 0.15 11.8 0.0 1.4 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_5 PF07728.14 ETO33058.1 - 0.12 12.4 0.0 0.34 10.9 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) Use1 PF09753.9 ETO33058.1 - 0.14 11.9 5.3 0.16 11.6 5.3 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 Enkurin PF13864.6 ETO33058.1 - 0.85 10.1 5.2 0.2 12.1 1.8 1.7 2 0 0 2 2 2 0 Calmodulin-binding Pkinase PF00069.25 ETO33059.1 - 5.2e-53 180.1 0.0 2.2e-52 178.0 0.0 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33059.1 - 1.1e-25 90.5 0.0 4.8e-25 88.3 0.0 1.9 1 1 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO33059.1 - 1.2e-24 83.9 10.3 2.2e-06 26.8 0.0 4.6 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO33059.1 - 6.6e-24 84.2 9.6 5.4e-12 46.0 1.3 2.9 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO33059.1 - 8.8e-19 65.8 5.0 2.4e-06 27.0 0.0 5.1 5 0 0 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ETO33059.1 - 4.1e-18 64.0 11.3 2.7e-07 29.8 0.2 4.6 4 0 0 4 4 4 4 EF hand EF-hand_8 PF13833.6 ETO33059.1 - 1.1e-12 47.6 10.1 4.3e-06 26.5 0.5 4.5 2 1 2 4 4 4 4 EF-hand domain pair SPARC_Ca_bdg PF10591.9 ETO33059.1 - 1.1e-08 35.4 5.6 0.00083 19.7 0.3 3.6 1 1 2 3 3 3 3 Secreted protein acidic and rich in cysteine Ca binding region Kdo PF06293.14 ETO33059.1 - 5.4e-07 29.2 0.0 1.1e-06 28.1 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO33059.1 - 0.00013 22.0 0.0 0.018 15.0 0.0 2.4 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO33059.1 - 0.0011 18.3 0.2 0.0088 15.4 0.0 2.4 2 1 0 2 2 2 1 Kinase-like EF-hand_9 PF14658.6 ETO33059.1 - 0.0046 17.2 0.3 0.067 13.5 0.1 2.7 2 1 0 2 2 2 1 EF-hand domain YrbL-PhoP_reg PF10707.9 ETO33059.1 - 0.0061 16.1 0.0 0.019 14.5 0.0 1.8 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL VCBS PF13517.6 ETO33059.1 - 0.074 13.6 0.4 8.7 7.0 0.2 2.8 2 0 0 2 2 2 0 Repeat domain in Vibrio, Colwellia, Bradyrhizobium and Shewanella PABP PF00658.18 ETO33060.1 - 0.0037 17.4 0.0 0.0065 16.6 0.0 1.4 1 0 0 1 1 1 1 Poly-adenylate binding protein, unique domain zf-TRAF PF02176.18 ETO33062.1 - 1.9e-06 28.5 7.0 7.6e-06 26.5 7.0 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger XRN_M PF17846.1 ETO33062.1 - 0.0026 16.8 10.7 0.004 16.2 10.7 1.2 1 0 0 1 1 1 1 Xrn1 helical domain Ribosomal_S14 PF00253.21 ETO33062.1 - 0.11 12.2 0.0 0.22 11.3 0.0 1.4 1 0 0 1 1 1 0 Ribosomal protein S14p/S29e Exonuc_VII_L PF02601.15 ETO33062.1 - 0.12 11.9 7.7 0.16 11.5 7.7 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit CPSF100_C PF13299.6 ETO33062.1 - 0.5 10.5 8.4 0.78 9.9 8.4 1.2 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4781 PF16013.5 ETO33062.1 - 1.7 7.4 7.0 2.8 6.7 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4781) DUF3112 PF11309.8 ETO33062.1 - 3.8 6.9 7.2 1.3e+02 1.8 7.2 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF3112) Csm1_N PF18504.1 ETO33062.1 - 5.2 7.5 24.8 1.6 9.2 7.8 2.7 1 1 1 2 2 2 0 Csm1 N-terminal domain DUF4407 PF14362.6 ETO33062.1 - 8 5.7 9.3 12 5.1 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FAM91_C PF14648.6 ETO33063.1 - 0.024 13.5 1.8 0.065 12.1 0.0 2.0 2 0 0 2 2 2 0 FAM91 C-terminus PVL_ORF50 PF07768.11 ETO33063.1 - 0.12 12.7 2.7 0.22 11.8 2.7 1.4 1 0 0 1 1 1 0 PVL ORF-50-like family SEEEED PF14797.6 ETO33063.1 - 0.17 12.1 7.3 0.3 11.2 7.3 1.4 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex Apis_Csd PF11671.8 ETO33063.1 - 0.65 10.0 8.8 1.3 9.0 8.8 1.4 1 0 0 1 1 1 0 Complementary sex determiner protein DHC_N2 PF08393.13 ETO33065.1 - 2.3e-11 43.4 6.9 2.3e-11 43.4 6.9 2.8 2 1 1 3 3 3 1 Dynein heavy chain, N-terminal region 2 Cas9_C PF18525.1 ETO33065.1 - 0.07 13.3 1.5 0.65 10.2 0.1 3.2 2 1 1 3 3 3 0 Cas9 C-terminal domain FAD_oxidored PF12831.7 ETO33065.1 - 0.11 11.8 1.8 0.16 11.2 1.8 1.4 1 0 0 1 1 1 0 FAD dependent oxidoreductase CCM2_C PF16545.5 ETO33065.1 - 3.9 8.1 8.9 0.32 11.5 0.3 3.4 3 1 0 3 3 3 0 Cerebral cavernous malformation protein, harmonin-homology Glyco_transf_92 PF01697.27 ETO33066.1 - 0.015 15.0 0.0 0.016 14.9 0.0 1.1 1 0 0 1 1 1 0 Glycosyltransferase family 92 Glyco_transf_25 PF01755.17 ETO33067.1 - 0.00048 20.0 0.5 0.038 13.9 0.1 2.4 2 0 0 2 2 2 2 Glycosyltransferase family 25 (LPS biosynthesis protein) WD40 PF00400.32 ETO33068.1 - 6.8e-17 61.5 13.4 8.3e-07 29.6 0.3 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33068.1 - 1.2e-05 24.2 0.1 0.02 13.6 0.0 3.0 3 0 0 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33068.1 - 1.3e-05 25.4 0.2 1.4 9.2 0.0 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Cerato-platanin PF07249.12 ETO33068.1 - 0.053 13.6 1.0 0.053 13.6 1.0 1.8 2 0 0 2 2 2 0 Cerato-platanin WD40 PF00400.32 ETO33069.1 - 7.1e-18 64.6 6.5 4.3e-06 27.3 0.4 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33069.1 - 1.2e-05 24.2 0.5 0.0061 15.3 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33069.1 - 0.0033 16.8 1.1 0.018 14.4 1.1 1.8 1 1 0 1 1 1 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO33069.1 - 0.013 15.8 0.1 0.21 11.9 0.0 2.4 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain PSI PF01437.25 ETO33069.1 - 0.044 14.3 2.0 0.13 12.8 2.0 1.8 1 1 0 1 1 1 0 Plexin repeat DUF4221 PF13970.6 ETO33069.1 - 0.34 10.4 4.0 0.83 9.1 0.1 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Serinc PF03348.15 ETO33070.1 - 0.03 13.3 1.5 0.061 12.2 1.5 1.5 1 0 0 1 1 1 0 Serine incorporator (Serinc) O-antigen_lig PF13425.6 ETO33070.1 - 0.058 12.2 0.8 0.1 11.4 0.8 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DUF733 PF05306.11 ETO33070.1 - 1.6 9.1 11.1 1.7 9.0 3.4 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF733) ETRAMP PF09716.10 ETO33070.1 - 6.5 6.9 9.6 0.96 9.6 4.2 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) WD40 PF00400.32 ETO33071.1 - 3.1e-12 46.8 7.1 5.5e-07 30.2 0.7 2.3 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO33071.1 - 0.0019 16.9 0.6 0.18 10.4 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 VWA_2 PF13519.6 ETO33072.1 - 0.00082 20.0 0.1 0.014 16.0 0.0 2.3 2 1 0 2 2 2 1 von Willebrand factor type A domain VWA PF00092.28 ETO33072.1 - 0.0025 18.1 0.1 0.13 12.5 0.0 2.3 2 1 0 2 2 2 1 von Willebrand factor type A domain MarR PF01047.22 ETO33072.1 - 0.052 13.5 0.0 0.64 10.0 0.0 2.4 2 0 0 2 2 2 0 MarR family VWA_3 PF13768.6 ETO33072.1 - 0.19 11.7 0.0 1 9.2 0.0 2.0 2 0 0 2 2 2 0 von Willebrand factor type A domain SPRY PF00622.28 ETO33073.1 - 4.7e-27 94.5 4.3 8.3e-15 55.0 1.6 2.3 2 0 0 2 2 2 2 SPRY domain Neuralized PF07177.12 ETO33073.1 - 7e-05 22.9 0.0 0.29 11.1 0.0 2.5 2 0 0 2 2 2 2 Neuralized CFAP91 PF14738.6 ETO33073.1 - 0.17 12.0 0.1 0.34 11.0 0.1 1.4 1 0 0 1 1 1 0 Cilia- and flagella-associated protein 91 Ras PF00071.22 ETO33074.1 - 2.4e-25 89.0 0.7 2.8e-25 88.8 0.7 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO33074.1 - 2.2e-05 24.6 0.3 3.7e-05 23.9 0.3 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO33074.1 - 0.012 15.1 0.2 0.018 14.5 0.2 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family Aminotran_1_2 PF00155.21 ETO33075.1 - 7.3e-19 68.2 0.0 9.8e-19 67.7 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Beta_elim_lyase PF01212.21 ETO33075.1 - 4.5e-05 22.9 0.0 7.9e-05 22.1 0.0 1.4 1 0 0 1 1 1 1 Beta-eliminating lyase Cys_Met_Meta_PP PF01053.20 ETO33075.1 - 0.019 13.5 0.1 0.04 12.4 0.0 1.4 2 0 0 2 2 2 0 Cys/Met metabolism PLP-dependent enzyme SR-25 PF10500.9 ETO33075.1 - 0.39 10.3 12.8 0.7 9.5 12.8 1.5 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 ETO33075.1 - 8.6 4.7 8.7 14 4.0 8.7 1.3 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) FAD_binding_6 PF00970.24 ETO33076.1 - 1.9e-09 37.7 0.0 5.2e-06 26.7 0.0 2.9 3 0 0 3 3 3 2 Oxidoreductase FAD-binding domain NAD_binding_1 PF00175.21 ETO33076.1 - 2.3e-09 37.8 0.0 9.5e-09 35.9 0.0 2.0 1 1 1 2 2 2 1 Oxidoreductase NAD-binding domain NAD_binding_6 PF08030.12 ETO33076.1 - 0.00095 19.3 0.0 0.0015 18.7 0.0 1.5 1 0 0 1 1 1 1 Ferric reductase NAD binding domain DUF1275 PF06912.11 ETO33079.1 - 0.0013 18.7 0.5 0.0019 18.1 0.5 1.3 1 1 0 1 1 1 1 Protein of unknown function (DUF1275) LptF_LptG PF03739.14 ETO33079.1 - 0.0023 16.8 1.5 0.0034 16.3 1.5 1.2 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG Orf78 PF06024.12 ETO33079.1 - 0.0092 16.3 1.1 0.018 15.3 0.5 1.9 1 1 1 2 2 2 1 Orf78 (ac78) DUF5589 PF17672.1 ETO33079.1 - 0.23 11.4 5.5 0.29 11.1 4.5 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5589) Bromodomain PF00439.25 ETO33080.1 - 1.1e-15 57.4 0.0 2.6e-15 56.2 0.0 1.6 1 0 0 1 1 1 1 Bromodomain T3SS_ATPase_C PF18269.1 ETO33080.1 - 0.0023 17.8 0.1 0.0059 16.4 0.1 1.7 1 0 0 1 1 1 1 T3SS EscN ATPase C-terminal domain DUF2987 PF11205.8 ETO33081.1 - 0.0097 15.8 0.5 0.013 15.4 0.5 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2987) ZZ PF00569.17 ETO33082.1 - 0.00094 18.9 1.7 0.00094 18.9 1.7 1.7 2 0 0 2 2 2 1 Zinc finger, ZZ type DUF4706 PF15797.5 ETO33083.1 - 0.071 13.6 0.5 0.16 12.5 0.1 1.8 2 1 0 2 2 2 0 Domain of unknown function (DUF4706) WD40 PF00400.32 ETO33084.1 - 2.3e-32 110.5 5.5 1.5e-07 32.0 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33084.1 - 5.3e-16 58.7 3.5 0.00033 20.9 0.0 6.1 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33084.1 - 1.6e-08 33.9 1.2 0.066 12.2 0.0 4.5 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33084.1 - 1.9e-07 30.2 2.1 0.13 10.8 0.0 4.0 3 1 1 4 4 4 4 Nucleoporin Nup120/160 Utp8 PF10395.9 ETO33084.1 - 6.1e-07 28.3 2.2 0.0043 15.6 0.1 3.1 2 1 1 3 3 3 3 Utp8 family WD40_like PF17005.5 ETO33084.1 - 3e-05 23.5 6.0 0.055 12.8 0.1 3.4 2 2 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO33084.1 - 0.00015 20.4 0.6 0.027 13.0 0.0 2.5 1 1 0 2 2 2 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO33084.1 - 0.022 14.7 0.0 34 4.6 0.0 4.4 5 0 0 5 5 5 0 PQQ enzyme repeat WD40 PF00400.32 ETO33085.1 - 4.8e-49 163.3 9.7 3.2e-10 40.4 0.1 6.1 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33085.1 - 1.9e-19 69.7 1.0 0.00016 21.9 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO33085.1 - 8.9e-07 29.0 0.6 3.5e-05 23.8 0.2 2.8 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO33085.1 - 1.1e-06 27.9 0.3 3 6.7 0.0 5.2 1 1 4 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33085.1 - 7.1e-05 21.6 6.3 0.41 9.2 0.3 4.5 2 1 3 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33085.1 - 0.00024 20.5 3.9 0.11 11.8 0.8 3.0 2 1 1 3 3 3 2 WD40-like domain Coatomer_WDAD PF04053.14 ETO33085.1 - 0.0019 17.3 1.2 0.012 14.7 0.3 2.3 1 1 0 2 2 2 1 Coatomer WD associated region PD40 PF07676.12 ETO33085.1 - 0.0056 16.6 1.9 13 5.9 0.0 5.0 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO33085.1 - 0.011 14.3 1.1 2.3 6.7 0.1 2.5 1 1 0 2 2 2 0 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO33085.1 - 0.038 13.6 0.3 0.84 9.2 0.1 2.5 1 1 1 2 2 2 0 PQQ-like domain DUF4988 PF16378.5 ETO33085.1 - 0.061 13.0 0.5 19 4.8 0.0 3.1 2 1 1 3 3 3 0 Domain of unknown function Lactonase PF10282.9 ETO33085.1 - 0.07 12.4 1.4 14 4.8 0.0 3.4 2 1 2 4 4 4 0 Lactonase, 7-bladed beta-propeller DUF1513 PF07433.11 ETO33085.1 - 0.072 12.2 0.0 9.7 5.2 0.0 3.3 1 1 3 4 4 4 0 Protein of unknown function (DUF1513) WD40 PF00400.32 ETO33086.1 - 2.9e-31 107.0 11.3 5.4e-06 27.0 0.4 6.4 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO33086.1 - 1.1e-08 34.2 2.0 0.12 11.0 0.1 4.2 1 1 1 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33086.1 - 1.3e-08 35.0 1.2 0.024 14.9 0.0 4.8 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain S10_plectin PF03501.15 ETO33087.1 - 0.016 15.2 0.1 0.039 14.0 0.1 1.6 1 0 0 1 1 1 0 Plectin/S10 domain WD40 PF00400.32 ETO33088.1 - 1.1e-35 121.0 26.5 1.2e-06 29.1 0.6 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33088.1 - 2e-13 50.5 2.3 0.01 16.1 0.0 5.7 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33088.1 - 3.9e-08 32.4 15.1 0.023 13.4 0.2 5.4 3 3 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33088.1 - 1.4e-06 27.9 7.8 0.00083 18.8 1.4 4.5 2 2 4 6 6 6 2 WD40-like domain TPR_12 PF13424.6 ETO33089.1 - 5.3e-13 49.1 0.0 1.7e-06 28.2 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33089.1 - 1.2e-08 34.6 0.0 0.0019 18.0 0.0 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33089.1 - 2.2e-07 30.4 0.1 0.019 15.0 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33089.1 - 7.4e-07 28.9 2.7 0.016 15.3 0.3 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33089.1 - 1.3e-05 24.8 7.5 0.017 15.0 0.4 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33089.1 - 0.0044 17.0 3.9 0.02 15.0 0.2 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33089.1 - 0.15 11.7 1.2 0.74 9.5 1.2 2.2 1 0 0 1 1 1 0 TPR repeat MIT PF04212.18 ETO33089.1 - 0.19 11.8 6.7 0.23 11.6 0.2 3.3 3 1 1 4 4 4 0 MIT (microtubule interacting and transport) domain Sugar_tr PF00083.24 ETO33091.1 - 4.9e-12 45.4 5.9 6.2e-12 45.1 5.9 1.1 1 0 0 1 1 1 1 Sugar (and other) transporter MFS_1 PF07690.16 ETO33091.1 - 8.1e-07 28.3 6.3 1e-06 27.9 6.3 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily Ac76 PF05814.11 ETO33091.1 - 0.96 9.5 0.0 0.96 9.5 0.0 2.5 3 0 0 3 3 3 0 Orf76 (Ac76) FPL PF09758.9 ETO33092.1 - 1.4e-47 161.4 12.5 2.7e-47 160.5 12.5 1.4 1 0 0 1 1 1 1 Uncharacterised conserved protein CCDC106 PF15794.5 ETO33092.1 - 0.33 10.6 3.4 0.49 10.1 3.4 1.2 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 Herpes_capsid PF06112.11 ETO33092.1 - 4.3 7.4 20.2 8 6.5 20.2 1.3 1 0 0 1 1 1 0 Gammaherpesvirus capsid protein Shisa PF13908.6 ETO33093.1 - 0.00064 20.0 0.2 0.00064 20.0 0.2 3.2 3 0 0 3 3 3 2 Wnt and FGF inhibitory regulator Sporozoite_P67 PF05642.11 ETO33093.1 - 0.77 7.8 14.7 0.53 8.3 5.5 2.2 2 0 0 2 2 2 0 Sporozoite P67 surface antigen Glyco_hydro_1 PF00232.18 ETO33094.1 - 0.065 11.6 0.7 0.068 11.6 0.7 1.0 1 0 0 1 1 1 0 Glycosyl hydrolase family 1 Apis_Csd PF11671.8 ETO33094.1 - 0.17 11.9 2.5 0.22 11.5 2.5 1.2 1 0 0 1 1 1 0 Complementary sex determiner protein Methyltransf_12 PF08242.12 ETO33094.1 - 0.21 12.4 1.9 0.22 12.3 1.2 1.5 1 1 1 2 2 2 0 Methyltransferase domain Arm PF00514.23 ETO33095.1 - 0.0047 16.9 0.2 12 6.1 0.0 3.9 3 1 0 4 4 4 2 Armadillo/beta-catenin-like repeat RTTN_N PF14726.6 ETO33095.1 - 0.013 16.3 0.2 1.1 10.1 0.1 2.3 2 1 0 2 2 2 0 Rotatin, an armadillo repeat protein, centriole functioning Mcm10 PF09332.11 ETO33097.1 - 0.055 12.9 6.7 0.062 12.7 6.7 1.0 1 0 0 1 1 1 0 Mcm10 replication factor DUF515 PF04415.12 ETO33098.1 - 0.042 12.2 4.4 0.051 12.0 4.4 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF515) PBP1_TM PF14812.6 ETO33099.1 - 0.015 15.7 8.1 0.018 15.4 8.1 1.1 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal DUF4637 PF15470.6 ETO33099.1 - 0.64 9.7 5.5 0.71 9.6 5.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) TRAP_alpha PF03896.16 ETO33099.1 - 1.3 8.2 5.3 1.3 8.2 5.3 1.0 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Zip PF02535.22 ETO33100.1 - 0.26 10.5 4.5 0.29 10.3 4.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter EOS1 PF12326.8 ETO33100.1 - 0.31 11.0 8.4 0.78 9.6 8.4 1.7 1 1 0 1 1 1 0 N-glycosylation protein Membralin PF09746.9 ETO33100.1 - 3.3 6.6 6.8 3.9 6.4 6.8 1.1 1 0 0 1 1 1 0 Tumour-associated protein Presenilin PF01080.17 ETO33100.1 - 6.5 5.4 12.7 7.3 5.2 12.7 1.0 1 0 0 1 1 1 0 Presenilin MGDG_synth PF06925.11 ETO33101.1 - 0.041 14.0 0.0 0.07 13.2 0.0 1.4 1 0 0 1 1 1 0 Monogalactosyldiacylglycerol (MGDG) synthase C2 PF00168.30 ETO33103.1 - 1.9e-09 37.8 0.0 3.3e-09 37.0 0.0 1.3 1 0 0 1 1 1 1 C2 domain 2OG-FeII_Oxy_3 PF13640.6 ETO33104.1 - 3.8e-12 46.9 0.0 8.7e-12 45.8 0.0 1.6 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy_4 PF13661.6 ETO33104.1 - 0.013 16.1 0.1 0.14 12.9 0.0 2.4 2 0 0 2 2 2 0 2OG-Fe(II) oxygenase superfamily Abhydrolase_1 PF00561.20 ETO33105.1 - 1.1e-05 25.2 0.0 1.4e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO33105.1 - 0.0004 21.1 0.0 0.00047 20.8 0.0 1.1 1 0 0 1 1 1 1 Alpha/beta hydrolase family EHN PF06441.12 ETO33105.1 - 0.037 14.4 0.0 0.41 11.0 0.0 2.2 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Whirly PF08536.11 ETO33105.1 - 0.18 11.6 0.0 0.3 10.9 0.0 1.3 1 0 0 1 1 1 0 Whirly transcription factor Kelch_6 PF13964.6 ETO33106.1 - 1.8e-08 34.3 0.5 0.036 14.4 0.1 4.4 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO33106.1 - 6.1e-07 28.9 0.4 6.1e-05 22.5 0.1 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO33106.1 - 8.5e-07 28.7 4.1 0.00075 19.4 0.1 4.9 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO33106.1 - 5.8e-06 26.2 0.3 0.00094 19.2 0.1 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO33106.1 - 6.4e-05 23.1 0.6 0.0027 18.0 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO33106.1 - 0.00036 20.5 4.8 0.038 14.0 0.1 4.7 6 0 0 6 6 6 1 Kelch motif Oxysterol_BP PF01237.18 ETO33107.1 - 2.9 6.6 10.5 0.1 11.4 2.5 2.1 1 1 1 2 2 2 0 Oxysterol-binding protein Methyltransf_11 PF08241.12 ETO33108.1 - 1.2e-15 58.0 0.1 4.3e-15 56.1 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO33108.1 - 2.3e-14 53.9 0.1 6.8e-14 52.3 0.0 1.8 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO33108.1 - 3.8e-11 43.6 0.0 8e-11 42.6 0.0 1.5 1 0 0 1 1 1 1 Methyltransferase domain MetW PF07021.12 ETO33108.1 - 7.2e-11 42.0 0.2 1.4e-10 41.1 0.2 1.5 1 1 0 1 1 1 1 Methionine biosynthesis protein MetW Methyltransf_23 PF13489.6 ETO33108.1 - 8e-11 42.0 0.1 1.2e-10 41.5 0.1 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO33108.1 - 1e-09 38.3 1.2 1.6e-09 37.7 1.2 1.4 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO33108.1 - 6e-07 29.0 0.2 4.1e-06 26.3 0.2 2.1 1 1 0 1 1 1 1 ubiE/COQ5 methyltransferase family DREV PF05219.12 ETO33108.1 - 0.00059 19.0 0.1 0.0017 17.5 0.0 1.7 2 0 0 2 2 2 1 DREV methyltransferase Methyltransf_32 PF13679.6 ETO33108.1 - 0.00086 19.3 0.0 0.0017 18.3 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ETO33108.1 - 0.008 16.3 0.0 0.014 15.5 0.0 1.4 1 1 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 ETO33108.1 - 0.0093 15.5 0.0 0.016 14.7 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase small domain AviRa PF11599.8 ETO33108.1 - 0.029 13.8 0.2 0.067 12.6 0.2 1.4 1 1 0 1 1 1 0 RRNA methyltransferase AviRa Pox_MCEL PF03291.16 ETO33108.1 - 0.029 13.5 0.2 0.054 12.6 0.2 1.4 1 0 0 1 1 1 0 mRNA capping enzyme RrnaAD PF00398.20 ETO33108.1 - 0.055 12.5 0.0 0.13 11.3 0.0 1.4 1 1 0 1 1 1 0 Ribosomal RNA adenine dimethylase Mrr_cat PF04471.12 ETO33109.1 - 2.7e-19 69.3 0.0 5.6e-19 68.3 0.0 1.5 1 0 0 1 1 1 1 Restriction endonuclease Mrr_cat_2 PF13156.6 ETO33109.1 - 3.1e-07 30.3 0.2 1.3e-06 28.3 0.0 2.1 2 0 0 2 2 2 1 Restriction endonuclease Myb_DNA-binding PF00249.31 ETO33109.1 - 0.00036 20.7 2.4 0.00077 19.6 2.4 1.6 1 0 0 1 1 1 1 Myb-like DNA-binding domain Myb_DNA-bind_6 PF13921.6 ETO33109.1 - 0.013 15.7 3.7 0.042 14.1 3.7 1.9 1 0 0 1 1 1 0 Myb-like DNA-binding domain SANT_DAMP1_like PF16282.5 ETO33109.1 - 0.063 13.5 0.5 0.063 13.5 0.5 2.8 3 0 0 3 3 3 0 SANT/Myb-like domain of DAMP1 DUF573 PF04504.14 ETO33109.1 - 0.36 11.5 10.4 6.1 7.6 2.4 3.3 3 0 0 3 3 3 0 Protein of unknown function, DUF573 Exonuc_VII_L PF02601.15 ETO33109.1 - 1.7 8.2 7.5 4.5 6.8 0.2 2.6 3 0 0 3 3 3 0 Exonuclease VII, large subunit Pkinase PF00069.25 ETO33110.1 - 5.8e-12 45.5 0.0 1.2e-11 44.5 0.0 1.6 1 0 0 1 1 1 1 Protein kinase domain RGS PF00615.19 ETO33110.1 - 3.5e-08 33.7 0.7 0.0008 19.7 0.0 3.2 3 0 0 3 3 3 2 Regulator of G protein signaling domain Pkinase_Tyr PF07714.17 ETO33110.1 - 0.068 12.4 0.2 0.16 11.2 0.1 1.7 2 0 0 2 2 2 0 Protein tyrosine kinase TFCD_C PF12612.8 ETO33111.1 - 0.062 13.1 0.0 0.14 12.0 0.0 1.5 2 0 0 2 2 2 0 Tubulin folding cofactor D C terminal RRN3 PF05327.11 ETO33112.1 - 0.06 11.9 7.1 0.1 11.1 7.1 1.3 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 Cwf_Cwc_15 PF04889.12 ETO33112.1 - 1 9.1 8.2 1.6 8.4 8.2 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein Kelch_2 PF07646.15 ETO33113.1 - 1.3e-07 31.3 2.7 0.00033 20.5 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO33113.1 - 3.2e-07 29.8 3.9 0.0029 17.2 0.4 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO33113.1 - 3.5e-07 30.1 6.5 1.1 9.4 0.3 5.6 6 0 0 6 6 6 3 Kelch motif Kelch_4 PF13418.6 ETO33113.1 - 7.2e-07 29.1 1.3 0.0039 17.2 0.0 4.3 5 0 0 5 5 5 2 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33113.1 - 8e-06 26.0 5.1 0.83 10.0 0.2 5.1 4 1 1 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO33113.1 - 0.0047 17.2 0.8 17 5.9 0.0 4.8 6 0 0 6 6 6 1 Galactose oxidase, central domain NCBP3 PF10309.9 ETO33113.1 - 0.19 11.6 0.9 0.43 10.5 0.9 1.6 1 0 0 1 1 1 0 Nuclear cap-binding protein subunit 3 zf-AD PF07776.15 ETO33114.1 - 0.1 12.8 1.9 0.32 11.3 0.2 2.7 2 0 0 2 2 2 0 Zinc-finger associated domain (zf-AD) EST1 PF10374.9 ETO33114.1 - 3.5 8.3 7.7 3.8 8.1 0.1 2.7 2 1 1 3 3 3 0 Telomerase activating protein Est1 Kelch_1 PF01344.25 ETO33116.1 - 1.4e-09 37.4 1.5 1.7e-06 27.5 0.4 4.1 4 1 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO33116.1 - 2.7e-08 33.6 0.0 0.01 15.8 0.2 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO33116.1 - 2.3e-06 27.7 3.0 0.75 10.2 0.3 3.8 3 1 1 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO33116.1 - 3e-05 23.8 1.1 0.11 12.5 0.2 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_3 PF13415.6 ETO33116.1 - 0.001 19.3 0.1 0.037 14.3 0.1 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO33116.1 - 0.004 17.1 0.1 0.55 10.3 0.1 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain Copper-bind PF00127.20 ETO33116.1 - 0.013 15.9 0.4 0.039 14.4 0.1 1.9 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family WD40 PF00400.32 ETO33117.1 - 3.6e-06 27.6 7.4 0.003 18.4 0.3 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat TPR_19 PF14559.6 ETO33118.1 - 1.1e-06 29.0 15.9 0.0035 17.8 3.8 3.9 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33118.1 - 9.1e-06 25.4 12.3 1 9.7 0.1 5.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_15 PF13429.6 ETO33118.1 - 3.8e-05 23.0 5.5 0.048 12.9 2.1 2.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33118.1 - 4.9e-05 23.8 11.6 1.1 10.2 0.2 5.6 3 2 3 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33118.1 - 0.00093 18.9 8.1 0.8 9.6 0.0 4.4 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33118.1 - 0.0062 16.2 1.6 1.2 8.9 0.0 3.9 5 0 0 5 5 5 1 TPR repeat TPR_12 PF13424.6 ETO33118.1 - 0.021 15.1 11.3 5.1 7.5 0.4 4.0 2 1 2 4 4 4 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33118.1 - 0.025 14.8 2.3 40 4.8 0.0 4.6 5 0 0 5 5 5 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33118.1 - 0.03 15.0 7.5 11 6.7 0.1 4.8 4 1 0 5 5 5 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO33118.1 - 0.045 13.8 4.6 0.23 11.5 0.7 3.2 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat TPR_20 PF14561.6 ETO33118.1 - 1.1 9.6 9.1 1.7 9.1 0.6 3.4 1 1 1 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO33119.1 - 5.2e-21 74.6 14.8 1.2e-06 29.1 1.9 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33119.1 - 1.6e-07 30.4 0.2 0.083 11.5 0.0 3.2 3 0 0 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33119.1 - 2.4e-05 24.5 0.0 0.47 10.8 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain NinG PF05766.12 ETO33119.1 - 7.5 6.4 7.2 1.5 8.7 0.5 2.4 2 1 1 3 3 3 0 Bacteriophage Lambda NinG protein zf-RING_5 PF14634.6 ETO33120.1 - 1.6 8.7 11.5 0.3 11.1 6.3 2.3 2 0 0 2 2 2 0 zinc-RING finger domain Menin PF05053.13 ETO33121.1 - 0.16 10.3 2.3 0.21 9.9 2.3 1.1 1 0 0 1 1 1 0 Menin ERG4_ERG24 PF01222.17 ETO33122.1 - 3.1e-14 52.6 0.9 3.7e-14 52.3 0.9 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family Kelch_6 PF13964.6 ETO33124.1 - 6.9e-07 29.3 4.4 0.5 10.7 0.0 4.5 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ETO33124.1 - 0.0002 21.5 0.7 0.035 14.4 0.0 4.3 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO33124.1 - 0.0023 17.8 8.9 0.025 14.5 0.1 5.0 6 1 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO33124.1 - 0.0055 16.3 5.6 0.013 15.0 0.0 4.2 5 1 0 5 5 5 1 Kelch motif Kelch_5 PF13854.6 ETO33124.1 - 0.025 14.6 6.1 7.2 6.7 0.1 4.7 5 0 0 5 5 5 0 Kelch motif efThoc1 PF11957.8 ETO33128.1 - 1.1e-16 60.6 3.0 1.6e-16 60.1 3.0 1.1 1 0 0 1 1 1 1 THO complex subunit 1 transcription elongation factor efThoc1 PF11957.8 ETO33129.1 - 4.8e-08 32.1 0.9 6.7e-08 31.6 0.8 1.5 1 1 0 1 1 1 1 THO complex subunit 1 transcription elongation factor Lebercilin PF15619.6 ETO33130.1 - 0.0076 15.9 9.9 0.0076 15.9 9.9 2.1 2 0 0 2 2 2 1 Ciliary protein causing Leber congenital amaurosis disease DUF3800 PF12686.7 ETO33130.1 - 0.045 14.4 0.8 0.16 12.6 0.8 2.3 1 1 0 1 1 1 0 Protein of unknown function (DUF3800) SseC PF04888.12 ETO33130.1 - 0.061 12.9 7.8 0.1 12.2 7.8 1.3 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family Chordopox_A13L PF05961.11 ETO33130.1 - 0.11 12.8 0.1 0.11 12.8 0.1 2.6 2 0 0 2 2 1 0 Chordopoxvirus A13L protein DUF1759 PF03564.15 ETO33130.1 - 0.22 11.5 8.9 0.056 13.4 5.3 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1759) DUF2203 PF09969.9 ETO33130.1 - 0.37 11.5 3.9 1.2 9.8 3.9 1.9 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF4407 PF14362.6 ETO33130.1 - 0.56 9.5 4.8 1 8.6 4.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) MRPL52 PF18699.1 ETO33130.1 - 0.59 10.4 6.7 3 8.1 6.7 2.3 1 0 0 1 1 1 0 Mitoribosomal protein mL52 TACC_C PF05010.14 ETO33130.1 - 0.78 9.5 23.4 0.019 14.8 10.7 3.1 1 1 2 3 3 3 0 Transforming acidic coiled-coil-containing protein (TACC), C-terminal XLF PF09302.11 ETO33130.1 - 1.3 9.1 10.1 3.7 7.7 10.1 1.7 1 1 0 1 1 1 0 XLF-Cernunnos, XRcc4-like factor, NHEJ component TolA_bind_tri PF16331.5 ETO33130.1 - 1.8 8.7 6.9 20 5.4 0.1 3.1 2 1 0 2 2 2 0 TolA binding protein trimerisation SlyX PF04102.12 ETO33130.1 - 8.9 7.0 7.6 11 6.8 1.7 3.7 4 0 0 4 4 4 0 SlyX Snapin_Pallidin PF14712.6 ETO33131.1 - 9.3e-11 42.0 5.7 1.9e-07 31.4 0.8 2.3 1 1 1 2 2 2 2 Snapin/Pallidin SHE3 PF17078.5 ETO33131.1 - 0.0063 16.3 4.8 0.0078 16.0 4.8 1.2 1 0 0 1 1 1 1 SWI5-dependent HO expression protein 3 GCP_C_terminal PF04130.13 ETO33131.1 - 0.0064 16.0 1.0 0.0073 15.8 1.0 1.1 1 0 0 1 1 1 1 Gamma tubulin complex component C-terminal DUF305 PF03713.13 ETO33131.1 - 0.0084 16.3 0.3 0.013 15.6 0.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF305) PRONE PF03759.13 ETO33131.1 - 0.012 14.5 1.6 0.014 14.2 1.6 1.0 1 0 0 1 1 1 0 PRONE (Plant-specific Rop nucleotide exchanger) DUF3543 PF12063.8 ETO33131.1 - 0.013 14.9 1.7 0.021 14.2 1.7 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3543) DUF4411 PF14367.6 ETO33131.1 - 0.032 14.1 0.9 0.04 13.8 0.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4411) Mit_ribos_Mrp51 PF11709.8 ETO33131.1 - 0.033 13.8 3.7 0.038 13.6 3.7 1.2 1 0 0 1 1 1 0 Mitochondrial ribosomal protein subunit MPP6 PF10175.9 ETO33131.1 - 0.059 13.9 9.2 0.071 13.6 9.2 1.1 1 0 0 1 1 1 0 M-phase phosphoprotein 6 DUF4407 PF14362.6 ETO33131.1 - 0.086 12.2 6.9 0.11 11.9 6.9 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Anoctamin PF04547.12 ETO33131.1 - 0.1 11.4 1.0 0.13 11.0 1.0 1.2 1 0 0 1 1 1 0 Calcium-activated chloride channel Mit_KHE1 PF10173.9 ETO33131.1 - 0.14 12.2 1.2 0.18 11.9 1.2 1.3 1 0 0 1 1 1 0 Mitochondrial K+-H+ exchange-related Hamartin PF04388.12 ETO33131.1 - 0.18 10.4 4.6 0.21 10.2 4.6 1.1 1 0 0 1 1 1 0 Hamartin protein ArAE_2_N PF10337.9 ETO33131.1 - 0.19 10.7 2.8 0.23 10.4 2.8 1.1 1 0 0 1 1 1 0 Putative ER transporter, 6TM, N-terminal DUF1840 PF08895.11 ETO33131.1 - 0.62 10.4 4.7 0.2 12.0 2.0 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1840) Noelin-1 PF12308.8 ETO33131.1 - 1 9.3 6.0 7.7 6.6 0.4 2.2 1 1 1 2 2 2 0 Neurogenesis glycoprotein DUF16 PF01519.16 ETO33131.1 - 1.5 9.4 10.1 2.5 8.6 9.6 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 Mod_r PF07200.13 ETO33131.1 - 1.7 8.7 14.8 0.49 10.5 9.5 2.0 1 1 1 2 2 2 0 Modifier of rudimentary (Mod(r)) protein POX PF07526.11 ETO33131.1 - 2.9 8.5 9.5 7.5 7.1 3.0 2.4 2 1 1 3 3 3 0 Associated with HOX Seryl_tRNA_N PF02403.22 ETO33131.1 - 4.3 7.6 14.3 1.2 9.4 8.5 2.2 1 1 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain FadA PF09403.10 ETO33131.1 - 7.9 7.0 18.5 27 5.3 10.0 2.9 2 1 1 3 3 3 0 Adhesion protein FadA RNA_pol_Rpb8 PF03870.15 ETO33132.1 - 3.8e-46 156.7 0.5 4.3e-46 156.6 0.5 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 ETO33132.1 - 0.0014 18.6 1.2 0.02 14.9 0.1 2.0 1 1 1 2 2 2 1 DNA-directed RNA polymerase, subunit G TOBE PF03459.17 ETO33132.1 - 0.076 13.3 0.0 0.15 12.3 0.0 1.5 1 0 0 1 1 1 0 TOBE domain WD40 PF00400.32 ETO33135.1 - 5.5e-09 36.5 9.7 5.8e-07 30.1 0.8 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33135.1 - 0.0041 17.4 0.0 0.018 15.4 0.0 2.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33135.1 - 0.0045 16.4 0.5 0.0045 16.4 0.5 2.4 2 0 0 2 2 2 1 WD40-like domain Yopt PF09467.10 ETO33135.1 - 0.054 13.6 0.9 0.46 10.6 0.3 2.5 2 0 0 2 2 2 0 Hypothetical protein Yopt ADIP PF11559.8 ETO33136.1 - 0.0062 16.6 1.4 0.0064 16.6 1.4 1.0 1 0 0 1 1 1 1 Afadin- and alpha -actinin-Binding CPSF_A PF03178.15 ETO33137.1 - 1.1e-14 54.6 0.0 3.7e-14 52.8 0.0 1.8 1 1 0 1 1 1 1 CPSF A subunit region MMS1_N PF10433.9 ETO33139.1 - 1.3e-26 93.3 0.8 2.3e-26 92.5 0.8 1.3 1 0 0 1 1 1 1 Mono-functional DNA-alkylating methyl methanesulfonate N-term Mif2_N PF15624.6 ETO33139.1 - 0.65 10.7 5.9 1.6 9.4 2.1 2.5 2 0 0 2 2 2 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal WD40 PF00400.32 ETO33142.1 - 2.7e-31 107.1 3.0 1.7e-07 31.8 0.0 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33142.1 - 5.2e-09 36.3 0.2 0.026 14.8 0.0 3.9 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33142.1 - 1.4e-05 23.9 0.2 0.0024 16.6 0.0 2.2 2 0 0 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO33142.1 - 0.00061 19.7 0.0 0.0052 16.7 0.0 2.0 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO33142.1 - 0.002 17.5 0.2 0.0028 17.0 0.2 1.4 1 0 0 1 1 1 1 WD40-like domain Ge1_WD40 PF16529.5 ETO33142.1 - 0.01 14.9 0.6 0.41 9.5 0.1 2.7 1 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40 PF00400.32 ETO33143.1 - 0.0019 19.0 0.2 0.0077 17.1 0.1 2.1 2 0 0 2 2 2 1 WD domain, G-beta repeat Kelch_3 PF13415.6 ETO33143.1 - 0.032 14.5 0.0 0.16 12.3 0.0 2.1 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33143.1 - 0.065 13.6 0.1 15 6.1 0.0 2.9 2 0 0 2 2 2 0 Kelch motif Vasculin PF15337.6 ETO33144.1 - 0.026 15.4 3.2 0.041 14.7 3.2 1.3 1 0 0 1 1 1 0 Vascular protein family Vasculin-like 1 MMADHC PF10229.9 ETO33144.1 - 0.031 14.0 1.1 0.037 13.8 1.1 1.1 1 0 0 1 1 1 0 Methylmalonic aciduria and homocystinuria type D protein FidL_like PF15941.5 ETO33144.1 - 0.068 13.6 2.0 0.098 13.1 2.0 1.3 1 0 0 1 1 1 0 FidL-like putative membrane protein S4 PF01479.25 ETO33145.1 - 0.36 10.6 2.2 7.8 6.3 0.1 2.4 2 0 0 2 2 2 0 S4 domain TMEM144 PF07857.12 ETO33145.1 - 2.5 7.0 3.5 5.5 5.8 3.5 1.6 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters PUD1_2 PF18457.1 ETO33147.1 - 1.7e-10 41.1 2.3 2.1e-07 31.1 3.0 2.6 1 1 1 2 2 2 2 Up-Regulated in long-lived daf-2 DUF346 PF03984.13 ETO33147.1 - 0.15 11.8 1.4 1.1 9.0 0.3 2.4 2 0 0 2 2 2 0 Repeat of unknown function (DUF346) G-alpha PF00503.20 ETO33148.1 - 2.1e-36 125.8 6.0 2.4e-36 125.6 6.0 1.0 1 0 0 1 1 1 1 G-protein alpha subunit MMS19_C PF12460.8 ETO33148.1 - 0.023 13.8 0.1 0.025 13.7 0.1 1.1 1 0 0 1 1 1 0 RNAPII transcription regulator C-terminal Glyco_hydro_53 PF07745.13 ETO33148.1 - 0.031 13.3 0.6 0.037 13.0 0.6 1.1 1 0 0 1 1 1 0 Glycosyl hydrolase family 53 Pik1 PF11522.8 ETO33148.1 - 0.1 12.6 0.3 0.27 11.2 0.3 1.7 1 0 0 1 1 1 0 Yeast phosphatidylinositol-4-OH kinase Pik1 WD40 PF00400.32 ETO33149.1 - 3.9e-50 166.7 12.9 8.8e-10 39.0 0.1 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33149.1 - 5.8e-24 84.2 1.1 0.00026 21.2 0.0 5.0 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33149.1 - 6.9e-16 58.1 0.1 0.0074 15.3 0.0 4.9 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33149.1 - 3.7e-14 52.8 0.0 0.0008 18.8 0.0 3.0 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO33149.1 - 1.7e-12 46.8 1.5 0.017 13.8 0.0 4.9 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO33149.1 - 3e-06 27.0 6.4 2.8 8.0 0.0 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO33149.1 - 5.7e-05 22.0 0.1 1.8 7.2 0.1 3.6 1 1 2 4 4 4 3 Dipeptidyl peptidase IV (DPP IV) N-terminal region Cytochrom_D1 PF02239.16 ETO33149.1 - 0.00018 20.2 0.1 0.0035 15.9 0.0 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO33149.1 - 0.0002 20.3 6.1 0.11 11.2 0.7 4.1 1 1 3 4 4 4 2 Nup133 N terminal like DUF5570 PF17731.1 ETO33149.1 - 0.00027 21.0 1.7 3.4 7.8 0.1 4.1 1 1 4 5 5 5 1 Family of unknown function (DUF5570) VID27 PF08553.10 ETO33149.1 - 0.00044 19.4 0.0 0.065 12.3 0.0 2.4 1 1 2 3 3 3 1 VID27 C-terminal WD40-like domain PQQ_2 PF13360.6 ETO33149.1 - 0.00088 18.9 0.2 0.0026 17.4 0.2 1.8 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 ETO33149.1 - 0.0033 17.3 0.0 1.1 9.3 0.1 3.8 3 1 0 3 3 3 1 PQQ enzyme repeat DUF1797 PF08796.10 ETO33149.1 - 0.0092 16.0 0.0 0.32 11.1 0.0 2.9 3 0 0 3 3 3 1 Protein of unknown function (DUF1797) DUF5122 PF17164.4 ETO33149.1 - 0.016 15.5 0.6 11 6.4 0.0 3.8 4 0 0 4 4 4 0 Domain of unknown function (DUF5122) beta-propeller Proteasome_A_N PF10584.9 ETO33149.1 - 3.7 7.3 13.1 28 4.5 0.0 5.2 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO33150.1 - 4e-12 46.4 3.4 2.6e-05 24.9 0.1 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO33150.1 - 0.0032 16.2 0.3 1.5 7.4 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Spc24 PF08286.11 ETO33150.1 - 0.0067 16.7 0.9 0.013 15.7 0.9 1.6 1 0 0 1 1 1 1 Spc24 subunit of Ndc80 Phage_GPO PF05929.11 ETO33150.1 - 0.15 11.6 1.9 2.5 7.6 3.7 1.8 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase WD40_like PF17005.5 ETO33150.1 - 0.24 10.7 8.4 0.075 12.4 0.9 2.4 2 1 1 3 3 3 0 WD40-like domain SMI1_KNR4 PF09346.10 ETO33150.1 - 0.48 10.8 4.0 1.6 9.1 4.0 1.9 1 1 0 1 1 1 0 SMI1 / KNR4 family (SUKH-1) RED_C PF07807.11 ETO33150.1 - 1.6 9.2 7.4 15 6.1 0.0 2.8 3 0 0 3 3 3 0 RED-like protein C-terminal region WD40 PF00400.32 ETO33151.1 - 6.1e-54 178.8 16.1 2.8e-09 37.4 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33151.1 - 3.3e-20 72.2 2.5 0.009 16.3 0.0 6.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33151.1 - 1.8e-09 37.0 1.0 0.33 9.9 0.0 5.8 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33151.1 - 9.4e-09 34.4 4.4 0.12 11.0 0.0 5.3 1 1 2 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO33151.1 - 1.8e-06 27.7 2.6 0.99 9.4 0.1 4.6 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO33151.1 - 7.2e-06 25.5 0.8 0.038 13.3 0.0 3.0 2 1 1 3 3 3 2 WD40-like domain Ubiquitin_3 PF14836.6 ETO33151.1 - 0.0085 16.1 0.0 5.9 7.0 0.0 3.4 2 1 1 3 3 3 1 Ubiquitin-like domain DUF4988 PF16378.5 ETO33151.1 - 0.024 14.3 0.5 12 5.5 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function Cytochrom_D1 PF02239.16 ETO33151.1 - 0.048 12.2 0.1 2 6.9 0.0 2.7 1 1 1 3 3 3 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO33151.1 - 0.47 10.2 1.2 77 3.1 0.0 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO33152.1 - 7.4e-54 178.5 26.2 3.3e-09 37.2 0.5 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33152.1 - 8e-23 80.6 4.8 0.0022 18.2 0.2 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33152.1 - 2.3e-10 39.9 0.6 0.012 14.6 0.0 5.7 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO33152.1 - 2e-08 33.9 3.4 0.12 12.3 0.1 5.2 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO33152.1 - 7.3e-08 31.5 1.4 0.59 8.7 0.0 4.6 3 1 2 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO33152.1 - 4.3e-07 30.0 1.7 0.0014 18.6 0.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO33152.1 - 6.8e-06 25.6 6.0 0.91 8.8 0.0 4.6 1 1 2 4 4 4 4 WD40-like domain DUF5570 PF17731.1 ETO33152.1 - 5.8e-05 23.2 1.7 17 5.5 0.0 4.9 1 1 4 5 5 5 2 Family of unknown function (DUF5570) WD40 PF00400.32 ETO33153.1 - 2.6e-22 78.7 16.6 2.5e-07 31.3 1.3 5.2 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33153.1 - 5e-10 39.6 0.8 0.0082 16.4 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33153.1 - 0.0016 17.2 3.8 0.23 10.1 1.0 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 RecO_N_2 PF13114.6 ETO33153.1 - 0.038 13.7 0.0 0.34 10.6 0.0 2.5 2 0 0 2 2 2 0 RecO N terminal CspB_prodomain PF18425.1 ETO33153.1 - 0.15 12.1 1.3 0.23 11.5 0.3 1.8 2 0 0 2 2 2 0 Csp protease B prodomain Kelch_6 PF13964.6 ETO33154.1 - 3.3e-07 30.4 5.3 0.0016 18.6 0.0 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO33154.1 - 1.7e-06 27.8 4.2 0.054 13.5 0.0 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO33154.1 - 1.5e-05 24.5 0.1 0.03 13.9 0.0 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO33154.1 - 0.00015 21.7 2.6 0.03 14.3 0.0 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO33154.1 - 0.0059 16.9 0.0 0.13 12.6 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO33154.1 - 0.016 15.2 0.0 0.09 12.8 0.0 2.3 2 0 0 2 2 2 0 Galactose oxidase, central domain RTX_C PF08339.10 ETO33156.1 - 0.037 14.1 1.7 0.039 14.0 1.7 1.1 1 0 0 1 1 1 0 RTX C-terminal domain DUF508 PF04370.12 ETO33156.1 - 0.046 13.5 0.1 0.048 13.4 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF508) WD40 PF00400.32 ETO33157.1 - 4.3e-10 40.0 3.4 4.6e-06 27.3 1.0 3.1 2 0 0 2 2 2 2 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO33157.1 - 0.00022 21.8 2.3 0.00022 21.8 2.3 2.4 2 1 0 2 2 2 1 TRAF-type zinc finger Nup160 PF11715.8 ETO33157.1 - 0.00049 18.9 0.1 0.00074 18.3 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33157.1 - 0.052 13.9 0.0 0.17 12.2 0.0 1.8 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain Golgin_A5 PF09787.9 ETO33157.1 - 0.69 9.3 16.8 1.2 8.5 16.8 1.3 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF3371 PF11851.8 ETO33157.1 - 0.79 10.8 6.5 0.57 11.3 3.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3371) RNase_H PF00075.24 ETO33158.1 - 1.6e-19 70.5 0.0 2.9e-19 69.7 0.0 1.4 1 0 0 1 1 1 1 RNase H zf-RVT PF13966.6 ETO33158.1 - 0.0004 21.0 0.2 0.0012 19.5 0.2 1.8 1 0 0 1 1 1 1 zinc-binding in reverse transcriptase RVT_3 PF13456.6 ETO33158.1 - 0.021 14.6 0.0 0.047 13.5 0.0 1.7 1 0 0 1 1 1 0 Reverse transcriptase-like CENP-P PF13096.6 ETO33158.1 - 0.085 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 CENP-A-nucleosome distal (CAD) centromere subunit, CENP-P His_Phos_1 PF00300.22 ETO33160.1 - 2.2e-10 40.6 1.2 6.9e-08 32.4 0.5 2.4 2 1 0 2 2 2 2 Histidine phosphatase superfamily (branch 1) FliD_N PF02465.18 ETO33161.1 - 3.3 8.5 22.5 0.045 14.4 13.6 2.5 3 0 0 3 3 3 0 Flagellar hook-associated protein 2 N-terminus zf-CCHC_4 PF14392.6 ETO33161.1 - 5.1 6.9 10.6 7.2 6.4 1.3 2.8 2 0 0 2 2 2 0 Zinc knuckle RVT_1 PF00078.27 ETO33162.1 - 1.6e-41 142.3 0.1 2.7e-41 141.5 0.1 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Laminin_G_3 PF13385.6 ETO33165.1 - 0.00094 19.3 0.8 0.022 14.9 0.8 2.2 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily ArsP_1 PF03773.13 ETO33165.1 - 0.015 14.5 0.1 0.023 13.9 0.1 1.3 1 0 0 1 1 1 0 Predicted permease adh_short PF00106.25 ETO33166.1 - 0.00019 20.9 0.0 0.00024 20.6 0.0 1.1 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO33166.1 - 0.00092 18.8 0.0 0.0011 18.6 0.0 1.1 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase LRR_6 PF13516.6 ETO33167.1 - 3.2e-14 51.7 0.6 2.7e-05 23.8 0.0 4.8 4 0 0 4 4 4 2 Leucine Rich repeat adh_short PF00106.25 ETO33167.1 - 2.9e-09 36.7 0.0 7.5e-09 35.3 0.0 1.7 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO33167.1 - 0.0049 16.4 0.0 0.017 14.7 0.0 1.8 2 0 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase Utp14 PF04615.13 ETO33167.1 - 0.12 10.9 27.0 0.19 10.3 27.0 1.2 1 0 0 1 1 1 0 Utp14 protein NPR3 PF03666.13 ETO33167.1 - 6.6 5.4 25.8 1.5 7.5 9.3 2.2 2 0 0 2 2 2 0 Nitrogen Permease regulator of amino acid transport activity 3 CHAT PF12770.7 ETO33170.1 - 1.2e-06 28.1 0.7 3.9e-06 26.5 0.7 1.9 1 1 0 1 1 1 1 CHAT domain NB-ARC PF00931.22 ETO33170.1 - 0.0011 18.3 0.3 0.1 11.7 0.0 3.1 3 0 0 3 3 3 1 NB-ARC domain Peptidase_C14 PF00656.22 ETO33170.1 - 0.0044 17.0 0.1 0.0044 17.0 0.1 1.9 2 0 0 2 2 2 1 Caspase domain NACHT PF05729.12 ETO33170.1 - 0.0063 16.5 0.0 0.046 13.6 0.0 2.4 2 0 0 2 2 2 1 NACHT domain AAA PF00004.29 ETO33170.1 - 0.018 15.4 2.8 0.12 12.9 0.0 3.5 4 1 1 5 5 5 0 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO33170.1 - 0.084 13.3 0.0 0.084 13.3 0.0 3.1 4 1 0 4 4 4 0 AAA ATPase domain ABC_tran PF00005.27 ETO33170.1 - 4.3 7.9 0.0 4.3 7.9 0.0 2.8 2 0 0 2 2 2 0 ABC transporter DUF4828 PF16110.5 ETO33172.1 - 0.69 10.4 3.8 1.4 9.4 0.2 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4828) HIP1_clath_bdg PF16515.5 ETO33172.1 - 1.9 9.2 9.7 1.1 9.9 1.3 2.6 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 RGS PF00615.19 ETO33175.1 - 0.022 15.0 0.1 0.049 13.9 0.1 1.7 1 0 0 1 1 1 0 Regulator of G protein signaling domain Cwf_Cwc_15 PF04889.12 ETO33175.1 - 4.4 7.0 10.8 2.8 7.6 3.7 2.4 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein UPA PF17217.3 ETO33176.1 - 0.016 15.1 0.1 0.019 14.9 0.1 1.0 1 0 0 1 1 1 0 UPA domain AGH PF17558.2 ETO33176.1 - 0.066 13.4 0.0 0.086 13.0 0.0 1.1 1 0 0 1 1 1 0 Androgenic gland hormone SRTM1 PF15872.5 ETO33179.1 - 0.14 12.3 6.5 0.1 12.8 3.1 2.3 2 1 1 3 3 3 0 Serine-rich and transmembrane domain-containing protein 1 Zip PF02535.22 ETO33180.1 - 0.082 12.1 0.1 0.089 12.0 0.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter MFS_2 PF13347.6 ETO33180.1 - 0.28 9.7 0.1 0.37 9.3 0.1 1.2 1 0 0 1 1 1 0 MFS/sugar transport protein SelR PF01641.18 ETO33181.1 - 4.1e-38 130.2 0.0 5.4e-38 129.8 0.0 1.1 1 0 0 1 1 1 1 SelR domain Spermine_synth PF01564.17 ETO33182.1 - 6.9e-35 120.2 0.0 1.1e-34 119.6 0.0 1.2 1 0 0 1 1 1 1 Spermine/spermidine synthase domain Spermine_synt_N PF17284.2 ETO33182.1 - 1e-12 47.7 0.0 2e-12 46.8 0.0 1.5 1 0 0 1 1 1 1 Spermidine synthase tetramerisation domain Methyltransf_30 PF05430.11 ETO33182.1 - 0.0036 17.2 0.0 0.008 16.1 0.0 1.6 1 0 0 1 1 1 1 S-adenosyl-L-methionine-dependent methyltransferase Cloacin_immun PF03513.14 ETO33182.1 - 0.027 14.8 0.0 0.069 13.5 0.0 1.6 1 0 0 1 1 1 0 Cloacin immunity protein KIX PF02172.16 ETO33182.1 - 0.056 13.7 0.1 11 6.4 0.0 2.6 2 0 0 2 2 2 0 KIX domain Methyltransf_25 PF13649.6 ETO33182.1 - 0.17 12.6 0.0 0.33 11.7 0.0 1.4 1 0 0 1 1 1 0 Methyltransferase domain COMM_domain PF07258.14 ETO33184.1 - 2.7e-10 40.2 0.0 7.5e-10 38.8 0.0 1.8 1 0 0 1 1 1 1 COMM domain TPR_2 PF07719.17 ETO33185.1 - 8.3e-23 78.6 20.8 8.4e-05 22.4 0.1 8.3 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_19 PF14559.6 ETO33185.1 - 1.2e-16 60.9 13.2 4.3e-06 27.1 0.6 6.5 5 1 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33185.1 - 2e-16 59.0 20.4 0.00067 19.4 0.1 7.4 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33185.1 - 1.3e-15 56.8 3.0 0.13 13.2 0.1 7.6 5 2 3 8 8 8 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33185.1 - 7.7e-14 50.7 16.3 0.044 14.0 0.1 8.1 8 0 0 8 8 7 5 Tetratricopeptide repeat TPR_12 PF13424.6 ETO33185.1 - 1.6e-13 50.7 15.9 0.00016 21.9 0.2 7.6 5 3 4 9 9 9 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33185.1 - 3.6e-12 45.4 1.0 0.014 15.3 0.0 5.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33185.1 - 6e-12 45.1 12.0 0.39 11.2 0.1 7.5 8 0 0 8 8 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33185.1 - 5.1e-08 33.0 11.4 0.78 10.5 0.1 7.6 8 0 0 8 8 7 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33185.1 - 5.8e-08 33.3 0.0 0.00015 22.4 0.0 4.0 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33185.1 - 1.2e-07 31.4 6.4 2 8.4 0.0 5.7 5 0 0 5 5 5 3 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO33185.1 - 1.5e-06 28.3 18.4 0.012 15.8 5.3 6.0 3 2 2 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_11 PF13414.6 ETO33185.1 - 0.00013 21.5 14.6 0.81 9.4 0.0 6.8 7 0 0 7 7 7 1 TPR repeat ANAPC8 PF04049.13 ETO33185.1 - 0.011 15.8 0.1 0.011 15.8 0.1 3.0 3 0 0 3 3 2 0 Anaphase promoting complex subunit 8 / Cdc23 TPR_4 PF07721.14 ETO33185.1 - 0.021 15.4 0.2 0.97 10.3 0.1 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat PPR PF01535.20 ETO33185.1 - 0.21 11.9 1.3 40 4.8 0.0 4.3 4 0 0 4 4 4 0 PPR repeat Fis1_TPR_C PF14853.6 ETO33185.1 - 0.46 10.6 7.2 6 7.0 0.0 4.4 4 0 0 4 4 3 0 Fis1 C-terminal tetratricopeptide repeat Exonuc_VII_L PF02601.15 ETO33185.1 - 3.4 7.1 11.3 0.69 9.4 6.9 2.2 2 0 0 2 2 2 0 Exonuclease VII, large subunit Aldo_ket_red PF00248.21 ETO33186.1 - 0.012 14.8 0.0 0.014 14.6 0.0 1.1 1 0 0 1 1 1 0 Aldo/keto reductase family MurB_C PF02873.16 ETO33186.1 - 0.086 12.9 0.0 0.14 12.2 0.0 1.3 1 0 0 1 1 1 0 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain Ribosomal_L15e PF00827.17 ETO33188.1 - 1.3e-56 191.4 11.5 2.5e-54 183.9 11.5 2.2 1 1 0 1 1 1 1 Ribosomal L15 Oxidored_molyb PF00174.19 ETO33189.1 - 9e-42 142.6 0.0 1.6e-41 141.7 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase molybdopterin binding domain Mo-co_dimer PF03404.16 ETO33189.1 - 2.9e-23 82.4 0.1 6.1e-23 81.4 0.1 1.5 1 0 0 1 1 1 1 Mo-co oxidoreductase dimerisation domain Cyt-b5 PF00173.28 ETO33189.1 - 6.1e-10 39.1 0.1 1.1e-07 31.9 0.0 2.7 2 0 0 2 2 2 2 Cytochrome b5-like Heme/Steroid binding domain BNR PF02012.20 ETO33189.1 - 0.39 10.9 2.7 0.96 9.7 0.1 3.2 3 0 0 3 3 3 0 BNR/Asp-box repeat p25-alpha PF05517.12 ETO33190.1 - 0.08 13.1 6.9 0.082 13.1 6.9 1.0 1 0 0 1 1 1 0 p25-alpha GDPD PF03009.17 ETO33190.1 - 0.15 11.8 3.0 0.15 11.8 3.0 1.0 1 0 0 1 1 1 0 Glycerophosphoryl diester phosphodiesterase family DUF4061 PF13270.6 ETO33190.1 - 0.31 11.4 6.8 0.34 11.3 6.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4061) Fmp27_WPPW PF10359.9 ETO33190.1 - 0.46 9.3 8.9 0.49 9.2 8.9 1.0 1 0 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF1764 PF08576.10 ETO33190.1 - 5.4 8.0 8.9 6.6 7.7 8.9 1.2 1 0 0 1 1 1 0 Eukaryotic protein of unknown function (DUF1764) Atg8 PF02991.16 ETO33191.1 - 0.02 15.1 0.0 5.5 7.2 0.0 2.4 2 0 0 2 2 2 0 Autophagy protein Atg8 ubiquitin like Coilin_N PF15862.5 ETO33191.1 - 0.022 14.5 3.1 0.047 13.5 3.1 1.4 1 0 0 1 1 1 0 Coilin N-terminus DUF1676 PF07898.13 ETO33191.1 - 0.28 11.2 2.3 0.38 10.8 1.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) RRM_1 PF00076.22 ETO33192.1 - 1.7e-11 43.7 0.1 2.5e-11 43.2 0.1 1.2 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO33192.1 - 0.0037 17.3 0.0 0.0051 16.8 0.0 1.2 1 0 0 1 1 1 1 RNA binding motif RRM_occluded PF16842.5 ETO33192.1 - 0.013 15.4 0.1 0.018 14.9 0.1 1.3 1 0 0 1 1 1 0 Occluded RNA-recognition motif Surfac_D-trimer PF09006.11 ETO33192.1 - 0.1 12.5 2.2 10 6.1 0.8 2.2 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation RRM_7 PF16367.5 ETO33192.1 - 0.12 12.5 0.0 0.68 10.1 0.0 1.9 1 1 1 2 2 2 0 RNA recognition motif WD40 PF00400.32 ETO33193.1 - 3.7e-49 163.6 23.8 8.4e-09 35.9 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33193.1 - 3.7e-21 75.2 5.4 0.0013 19.0 0.0 5.9 2 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33193.1 - 1.5e-08 34.0 0.5 0.59 9.0 0.0 4.6 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33193.1 - 2.7e-08 33.5 11.8 0.0029 17.0 0.1 4.1 2 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO33193.1 - 0.00038 19.2 2.3 1.3 7.6 0.1 3.6 1 1 2 4 4 4 2 Nucleoporin Nup120/160 PQQ PF01011.21 ETO33193.1 - 0.001 18.9 0.0 0.2 11.7 0.0 3.6 4 0 0 4 4 4 1 PQQ enzyme repeat Nbas_N PF15492.6 ETO33193.1 - 0.0044 16.4 0.8 4.5 6.5 0.0 3.4 2 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO33193.1 - 0.12 12.4 0.3 26 4.9 0.0 3.3 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat zf-C3HC4_3 PF13920.6 ETO33194.1 - 4.9e-07 29.5 16.2 4.9e-07 29.5 16.2 1.9 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) SAM_2 PF07647.17 ETO33194.1 - 0.00044 20.3 0.8 0.0025 17.9 0.1 2.7 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO33194.1 - 0.0098 16.3 0.1 0.0098 16.3 0.1 2.6 2 0 0 2 2 1 1 SAM domain (Sterile alpha motif) APG6_N PF17675.1 ETO33194.1 - 0.016 15.8 5.8 0.016 15.8 5.8 4.5 5 0 0 5 5 5 0 Apg6 coiled-coil region Suppressor_APC PF11414.8 ETO33194.1 - 0.056 13.5 3.4 0.12 12.4 0.5 2.9 2 0 0 2 2 2 0 Adenomatous polyposis coli tumour suppressor protein Tctex-1 PF03645.13 ETO33194.1 - 0.075 13.3 0.1 0.34 11.2 0.1 2.1 1 0 0 1 1 1 0 Tctex-1 family NPV_P10 PF05531.12 ETO33194.1 - 1.1 9.7 6.7 0.6 10.6 1.1 3.2 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein zf-C3HC4 PF00097.25 ETO33194.1 - 1.6 8.7 18.1 5.9 6.8 18.1 2.1 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Lzipper-MIP1 PF14389.6 ETO33194.1 - 2.3 8.6 9.2 0.1 12.9 2.2 2.5 2 0 0 2 2 1 0 Leucine-zipper of ternary complex factor MIP1 FlxA PF14282.6 ETO33194.1 - 3.5 7.7 14.3 0.3 11.1 4.3 3.2 2 0 0 2 2 2 0 FlxA-like protein DUF2968 PF11180.8 ETO33194.1 - 7.2 6.2 10.8 0.06 13.0 1.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2968) zf-TRAF PF02176.18 ETO33195.1 - 0.0027 18.4 1.2 0.0027 18.4 1.2 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger UPF0556 PF10572.9 ETO33195.1 - 0.015 14.7 0.3 0.026 14.0 0.3 1.4 1 0 0 1 1 1 0 Uncharacterised protein family UPF0556 TetR_C_24 PF17932.1 ETO33195.1 - 0.04 14.2 0.1 0.069 13.4 0.1 1.4 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain WD40 PF00400.32 ETO33196.1 - 5e-13 49.3 10.8 1.7e-05 25.4 0.0 3.8 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33196.1 - 0.0075 15.0 2.5 6.4 5.3 0.1 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO33197.1 - 2.2e-15 56.8 4.3 0.019 15.8 0.2 6.8 6 1 1 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33197.1 - 2.8e-12 46.8 1.6 0.16 12.3 0.0 7.4 3 1 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO33197.1 - 3.3e-08 33.7 0.4 0.0078 16.1 0.0 3.0 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO33197.1 - 9.8e-07 28.6 0.1 0.53 10.3 0.0 6.0 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO33197.1 - 8.1e-06 25.1 0.4 0.0021 17.2 0.2 2.7 1 1 1 2 2 2 2 Coatomer WD associated region Nucleoporin_N PF08801.11 ETO33197.1 - 0.00016 20.6 0.9 1.7 7.3 0.0 3.8 3 2 0 3 3 3 3 Nup133 N terminal like PQQ_2 PF13360.6 ETO33197.1 - 0.00031 20.4 0.0 0.0028 17.3 0.0 2.4 2 1 0 2 2 2 1 PQQ-like domain DPPIV_N PF00930.21 ETO33197.1 - 0.0017 17.2 0.7 14 4.3 0.0 4.0 2 1 2 4 4 4 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO33197.1 - 0.0017 18.2 0.0 0.42 10.6 0.0 3.8 3 0 0 3 3 3 1 PQQ enzyme repeat Chibby PF14645.6 ETO33197.1 - 0.81 10.1 4.8 1.7 9.1 3.7 2.0 1 1 1 2 2 2 0 Chibby family DUF3915 PF13054.6 ETO33200.1 - 1.1 9.3 34.3 47 4.0 0.1 3.2 2 1 0 2 2 2 0 Protein of unknown function (DUF3915) RSB_motif PF16294.5 ETO33200.1 - 2.6 8.3 25.5 1.2 9.4 19.2 2.4 2 0 0 2 2 2 0 RNSP1-SAP18 binding (RSB) motif Afi1 PF07792.12 ETO33200.1 - 4.4 7.8 11.0 22 5.6 6.9 2.1 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking RXT2_N PF08595.11 ETO33200.1 - 8.8 6.3 14.6 18 5.3 0.1 2.1 2 0 0 2 2 2 0 RXT2-like, N-terminal SGT1 PF07093.11 ETO33201.1 - 0.093 11.2 16.5 0.13 10.6 16.5 1.2 1 0 0 1 1 1 0 SGT1 protein Paramyxo_ncap PF00973.19 ETO33201.1 - 1.1 8.1 9.3 1.5 7.7 9.3 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein Nop14 PF04147.12 ETO33201.1 - 1.5 6.9 24.1 2 6.5 24.1 1.1 1 0 0 1 1 1 0 Nop14-like family GEMIN8 PF15348.6 ETO33201.1 - 3.9 7.7 15.4 6.1 7.1 15.4 1.4 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 DUF365 PF04033.12 ETO33202.1 - 0.21 11.9 1.6 28 5.1 0.0 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF365) Orf78 PF06024.12 ETO33203.1 - 0.0033 17.7 5.1 0.34 11.2 0.5 3.0 3 0 0 3 3 3 2 Orf78 (ac78) TRAP_beta PF05753.14 ETO33203.1 - 0.068 12.6 0.0 0.12 11.8 0.0 1.3 1 0 0 1 1 1 0 Translocon-associated protein beta (TRAPB) DUF4522 PF15022.6 ETO33203.1 - 0.11 12.8 0.3 0.17 12.1 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4522) Ank_3 PF13606.6 ETO33204.1 - 1.5e-15 55.7 0.0 1e-05 25.5 0.0 3.9 3 0 0 3 3 3 3 Ankyrin repeat Ank_2 PF12796.7 ETO33204.1 - 1e-14 54.9 0.0 6.2e-12 45.9 0.0 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO33204.1 - 5.2e-13 49.2 0.2 0.00069 20.1 0.0 3.6 3 0 0 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO33204.1 - 4.9e-12 45.7 0.3 6e-05 23.3 0.1 3.7 3 0 0 3 3 3 3 Ankyrin repeat Ank_5 PF13857.6 ETO33204.1 - 5.6e-07 29.7 0.2 4.2e-05 23.7 0.1 5.1 4 1 0 5 5 5 3 Ankyrin repeats (many copies) TFIIA PF03153.13 ETO33204.1 - 0.07 13.1 49.9 0.0097 15.9 40.7 2.1 2 0 0 2 2 2 0 Transcription factor IIA, alpha/beta subunit WD40 PF00400.32 ETO33205.1 - 5.6e-05 23.8 0.4 0.00019 22.2 0.4 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat PRP38_assoc PF12871.7 ETO33206.1 - 5.1 7.8 19.5 0.11 13.2 12.5 1.8 2 0 0 2 2 2 0 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Ribosomal_L18p PF00861.22 ETO33207.1 - 0.063 13.6 0.6 0.98 9.8 0.0 2.4 2 0 0 2 2 2 0 Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast Lustrin_cystein PF14625.6 ETO33207.1 - 0.11 12.9 0.0 0.29 11.5 0.0 1.7 1 0 0 1 1 1 0 Lustrin, cysteine-rich repeated domain BTB PF00651.31 ETO33208.1 - 7.8e-08 32.5 0.2 2.2e-07 31.1 0.2 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ETO33208.1 - 6.2e-07 29.5 0.6 6.2e-07 29.5 0.6 3.0 3 1 0 3 3 3 1 BTB And C-terminal Kelch MlaC PF05494.12 ETO33208.1 - 0.00087 19.1 0.1 0.002 17.9 0.1 1.5 1 0 0 1 1 1 1 MlaC protein CRPV_capsid PF08762.10 ETO33210.1 - 0.16 11.6 0.0 0.25 11.0 0.0 1.3 1 0 0 1 1 1 0 CRPV capsid protein like Dpy-30 PF05186.13 ETO33211.1 - 1.1e-09 37.9 0.0 2.2e-09 36.9 0.0 1.4 1 0 0 1 1 1 1 Dpy-30 motif DUF2203 PF09969.9 ETO33211.1 - 0.12 13.1 4.0 0.25 12.1 4.0 1.4 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) DUF4606 PF15379.6 ETO33212.1 - 0.12 12.6 0.1 0.19 12.0 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4606) Pkinase PF00069.25 ETO33214.1 - 3.2e-27 95.5 9.3 8.2e-23 81.1 0.3 3.1 2 1 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33214.1 - 8.2e-20 71.2 2.0 4.4e-14 52.4 0.0 3.4 2 1 1 3 3 3 2 Protein tyrosine kinase Kdo PF06293.14 ETO33214.1 - 0.00012 21.5 0.0 0.00044 19.7 0.0 1.8 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family Haspin_kinase PF12330.8 ETO33214.1 - 0.026 13.5 21.2 0.0043 16.0 15.1 2.7 1 1 1 2 2 2 0 Haspin like kinase domain Kinase-like PF14531.6 ETO33214.1 - 0.038 13.3 0.1 0.075 12.3 0.1 1.4 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO33214.1 - 0.061 13.2 0.0 0.15 11.9 0.0 1.6 2 0 0 2 2 2 0 Phosphotransferase enzyme family Exo5 PF09810.9 ETO33214.1 - 0.88 9.0 10.9 0.011 15.3 1.5 2.3 1 1 2 3 3 3 0 Exonuclease V - a 5' deoxyribonuclease AAR2 PF05282.11 ETO33214.1 - 2.4 7.5 10.1 6.7 6.0 10.1 1.9 1 1 0 1 1 1 0 AAR2 protein Methyltransf_12 PF08242.12 ETO33214.1 - 3.5 8.4 15.8 0.5 11.1 0.8 2.6 1 1 1 2 2 2 0 Methyltransferase domain Connexin PF00029.19 ETO33214.1 - 6.7 6.4 11.1 0.21 11.3 1.2 2.5 2 1 1 3 3 3 0 Connexin Kelch_6 PF13964.6 ETO33215.1 - 6.7e-05 23.0 3.8 0.18 12.1 0.0 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO33215.1 - 0.00023 21.0 2.9 0.043 13.8 0.1 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO33215.1 - 0.00031 20.3 3.0 0.012 15.2 0.2 3.3 3 1 0 3 3 3 1 Kelch motif Glyoxal_oxid_N PF07250.11 ETO33215.1 - 0.0011 18.3 0.5 0.0085 15.3 0.1 2.3 2 1 0 2 2 2 1 Glyoxal oxidase N-terminus Kelch_5 PF13854.6 ETO33215.1 - 0.0089 16.0 4.0 5.1 7.2 0.6 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO33215.1 - 0.16 12.0 0.0 0.6 10.2 0.0 2.0 1 0 0 1 1 1 0 Galactose oxidase, central domain LamB PF02264.15 ETO33216.1 - 0.01 15.8 0.2 0.014 15.3 0.2 1.2 1 0 0 1 1 1 1 LamB porin Fer2_3 PF13085.6 ETO33216.1 - 0.12 12.4 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 2Fe-2S iron-sulfur cluster binding domain Linker_histone PF00538.19 ETO33217.1 - 0.015 15.6 0.2 0.025 14.9 0.2 1.3 1 0 0 1 1 1 0 linker histone H1 and H5 family UCH PF00443.29 ETO33219.1 - 2.1e-70 237.2 0.0 4.6e-69 232.8 0.0 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase Tudor-knot PF11717.8 ETO33219.1 - 0.037 13.9 0.1 0.12 12.3 0.1 1.9 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain DUF4154 PF13689.6 ETO33219.1 - 0.046 14.0 0.1 0.13 12.5 0.1 1.7 1 0 0 1 1 1 0 YfiR/HmsC-like Aldedh PF00171.22 ETO33220.1 - 3.6e-36 124.7 0.4 1.2e-20 73.5 0.1 2.0 2 0 0 2 2 2 2 Aldehyde dehydrogenase family Cellulase PF00150.18 ETO33220.1 - 0.028 13.9 0.0 0.056 12.9 0.0 1.4 1 0 0 1 1 1 0 Cellulase (glycosyl hydrolase family 5) Viral_protease PF08715.10 ETO33220.1 - 0.047 13.0 0.5 0.07 12.5 0.5 1.2 1 0 0 1 1 1 0 Papain like viral protease BLOC1_2 PF10046.9 ETO33221.1 - 0.22 11.8 7.2 7.7 6.9 1.9 3.9 2 1 1 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 DUF3837 PF12939.7 ETO33221.1 - 1.4 9.3 6.1 0.65 10.4 0.6 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF3837) Syndecan PF01034.20 ETO33222.1 - 0.00022 21.1 1.3 0.00044 20.1 1.3 1.4 1 0 0 1 1 1 1 Syndecan domain MOR2-PAG1_N PF14222.6 ETO33222.1 - 0.0025 16.8 0.1 0.01 14.8 0.0 1.8 1 1 1 2 2 2 1 Cell morphogenesis N-terminal SAM_2 PF07647.17 ETO33222.1 - 0.0052 16.9 0.1 0.0097 16.0 0.1 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Cadherin_C_2 PF16492.5 ETO33222.1 - 0.014 16.1 0.0 0.029 15.1 0.0 1.5 1 0 0 1 1 1 0 Cadherin cytoplasmic C-terminal Shisa PF13908.6 ETO33222.1 - 0.04 14.2 0.1 0.065 13.5 0.1 1.5 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator NECFESHC PF16621.5 ETO33222.1 - 0.078 13.0 1.2 0.63 10.0 0.1 2.3 2 0 0 2 2 2 0 SH3 terminal domain of 2nd SH3 on Neutrophil cytosol factor 1 SAM_1 PF00536.30 ETO33222.1 - 0.089 13.2 0.1 0.2 12.1 0.1 1.6 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF5412 PF17428.2 ETO33222.1 - 0.089 12.6 0.0 0.2 11.5 0.0 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5412) Pkinase PF00069.25 ETO33223.1 - 4.8e-40 137.6 0.0 1.4e-25 90.2 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33223.1 - 3.1e-22 79.1 0.0 1.3e-18 67.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO33223.1 - 1.6e-05 23.9 0.0 1.8e-05 23.7 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase Kdo PF06293.14 ETO33223.1 - 0.0023 17.3 0.0 0.0039 16.6 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO33223.1 - 0.0027 17.1 0.0 0.45 9.8 0.0 2.1 2 0 0 2 2 2 2 Kinase-like APH PF01636.23 ETO33223.1 - 0.0063 16.5 0.0 0.01 15.8 0.0 1.3 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO33223.1 - 0.05 13.2 0.1 0.088 12.4 0.1 1.5 1 0 0 1 1 1 0 RIO1 family DUF2076 PF09849.9 ETO33223.1 - 1.2 9.1 6.5 1.8 8.6 6.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) EF-hand_1 PF00036.32 ETO33225.1 - 1.5e-07 30.4 9.1 0.00068 19.0 0.3 3.6 3 0 0 3 3 3 2 EF hand EF-hand_6 PF13405.6 ETO33225.1 - 3e-07 29.8 2.4 0.019 14.9 0.1 3.2 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO33225.1 - 2.6e-06 27.2 3.2 0.034 14.0 0.1 2.8 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_7 PF13499.6 ETO33225.1 - 2.3e-05 24.8 11.4 0.0034 17.8 0.7 3.6 2 2 2 4 4 4 4 EF-hand domain pair EF-hand_5 PF13202.6 ETO33225.1 - 4.4e-05 22.8 13.5 0.00013 21.3 0.7 3.7 4 0 0 4 4 4 2 EF hand Caleosin PF05042.13 ETO33225.1 - 0.013 15.4 0.2 0.59 10.0 0.1 2.3 2 0 0 2 2 2 0 Caleosin related protein EF-hand_4 PF12763.7 ETO33225.1 - 0.013 15.4 7.5 0.22 11.5 0.7 3.2 3 1 1 4 4 4 0 Cytoskeletal-regulatory complex EF hand GAGA_bind PF06217.12 ETO33225.1 - 0.023 15.0 7.5 0.03 14.6 7.5 1.1 1 0 0 1 1 1 0 GAGA binding protein-like family DDHD PF02862.17 ETO33225.1 - 0.13 12.4 5.7 0.2 11.8 5.7 1.3 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO33225.1 - 3.8 6.2 7.9 4.3 6.0 7.9 1.2 1 0 0 1 1 1 0 Presenilin ALMT PF11744.8 ETO33225.1 - 7.1 5.3 11.6 8.7 5.1 11.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter Myc_N PF01056.18 ETO33226.1 - 0.00027 20.9 3.6 0.00033 20.7 3.6 1.2 1 0 0 1 1 1 1 Myc amino-terminal region CNDH2_C PF16858.5 ETO33226.1 - 0.00052 20.0 4.4 0.00056 19.9 4.4 1.2 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term RXT2_N PF08595.11 ETO33226.1 - 0.0023 18.0 10.7 0.0042 17.1 10.7 1.4 1 0 0 1 1 1 1 RXT2-like, N-terminal SID-1_RNA_chan PF13965.6 ETO33226.1 - 0.0041 15.6 1.4 0.0051 15.3 1.4 1.2 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Cwf_Cwc_15 PF04889.12 ETO33226.1 - 0.0043 16.8 13.6 0.0071 16.1 13.6 1.3 1 0 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein NARP1 PF12569.8 ETO33226.1 - 0.0083 15.1 8.6 0.011 14.7 8.6 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 FYDLN_acid PF09538.10 ETO33226.1 - 0.013 16.2 10.4 0.022 15.5 10.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Slu7 PF11708.8 ETO33226.1 - 0.017 14.9 9.9 0.024 14.4 9.9 1.2 1 0 0 1 1 1 0 Pre-mRNA splicing Prp18-interacting factor DUF1168 PF06658.12 ETO33226.1 - 0.018 14.9 18.1 0.028 14.2 18.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) DAG_kinase_N PF14513.6 ETO33226.1 - 0.019 15.2 3.8 0.029 14.6 3.8 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus FAM176 PF14851.6 ETO33226.1 - 0.028 14.1 6.5 0.06 13.0 6.5 1.6 1 0 0 1 1 1 0 FAM176 family BT1 PF03092.16 ETO33226.1 - 0.028 12.6 1.5 0.033 12.4 1.5 1.2 1 0 0 1 1 1 0 BT1 family Strabismus PF06638.11 ETO33226.1 - 0.047 12.3 3.0 0.063 11.9 3.0 1.1 1 0 0 1 1 1 0 Strabismus protein PPL5 PF18168.1 ETO33226.1 - 0.056 12.7 7.8 0.076 12.3 7.8 1.1 1 0 0 1 1 1 0 Prim-pol family 5 ETRAMP PF09716.10 ETO33226.1 - 0.059 13.4 0.0 0.19 11.8 0.0 1.9 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Astro_capsid_p PF12226.8 ETO33226.1 - 0.064 12.4 8.4 0.091 11.9 8.4 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DUF4746 PF15928.5 ETO33226.1 - 0.065 12.6 12.2 0.09 12.2 12.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) PIG-S PF10510.9 ETO33226.1 - 0.066 12.0 2.5 0.084 11.7 2.5 1.1 1 0 0 1 1 1 0 Phosphatidylinositol-glycan biosynthesis class S protein EF-hand_7 PF13499.6 ETO33226.1 - 0.067 13.6 5.0 0.3 11.6 0.1 3.1 2 1 1 3 3 3 0 EF-hand domain pair Neur_chan_memb PF02932.16 ETO33226.1 - 0.071 13.2 0.4 0.094 12.8 0.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Asp-B-Hydro_N PF05279.11 ETO33226.1 - 0.15 12.1 11.5 0.18 11.9 11.5 1.2 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region Connexin PF00029.19 ETO33226.1 - 0.15 11.8 2.4 0.25 11.1 2.4 1.6 1 0 0 1 1 1 0 Connexin DUF688 PF05097.12 ETO33226.1 - 0.19 10.8 8.2 0.26 10.4 8.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF688) DNA_pol_phi PF04931.13 ETO33226.1 - 0.21 9.7 12.1 0.29 9.2 12.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi NOA36 PF06524.12 ETO33226.1 - 0.22 10.8 9.3 0.32 10.3 9.3 1.2 1 0 0 1 1 1 0 NOA36 protein NusG_II PF07009.11 ETO33226.1 - 0.27 11.5 0.2 0.27 11.5 0.2 2.3 2 0 0 2 2 2 0 NusG domain II Pox_Ag35 PF03286.14 ETO33226.1 - 0.3 10.8 13.8 0.47 10.2 13.8 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SelP_N PF04592.14 ETO33226.1 - 0.32 10.4 7.8 0.48 9.8 7.8 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region RNA_pol_3_Rpc31 PF11705.8 ETO33226.1 - 0.55 10.4 18.8 0.94 9.7 18.8 1.3 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Importin_rep_6 PF18829.1 ETO33226.1 - 0.57 10.3 8.3 0.13 12.4 4.6 1.9 2 0 0 2 2 2 0 Importin repeat 6 Afi1 PF07792.12 ETO33226.1 - 0.59 10.6 10.6 1.2 9.6 10.6 1.5 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking OAD_gamma PF04277.13 ETO33226.1 - 1.1 9.9 10.1 2.8 8.6 2.5 2.4 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain PBP_sp32 PF07222.12 ETO33226.1 - 1.1 8.7 10.9 1.7 8.1 10.9 1.3 1 0 0 1 1 1 0 Proacrosin binding protein sp32 DUF3464 PF11947.8 ETO33226.1 - 1.3 8.8 5.8 2.1 8.1 5.8 1.4 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 PAF PF15715.5 ETO33226.1 - 1.5 9.4 10.9 2.6 8.6 10.9 1.4 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Prothymosin PF03247.14 ETO33226.1 - 2.1 8.8 24.4 0.1 13.0 17.5 1.9 2 0 0 2 2 2 0 Prothymosin/parathymosin family DUF2076 PF09849.9 ETO33226.1 - 3.3 7.7 7.6 5.5 7.0 7.6 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) DUF2500 PF10694.9 ETO33226.1 - 3.4 8.2 8.4 13 6.3 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2500) Iwr1 PF08574.10 ETO33226.1 - 3.7 8.6 18.8 13 6.9 18.8 2.0 1 1 0 1 1 1 0 Transcription factor Iwr1 Zip PF02535.22 ETO33226.1 - 4.2 6.5 5.9 6.6 5.8 5.9 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter PBP1_TM PF14812.6 ETO33226.1 - 7.9 6.9 21.5 30 5.1 21.4 2.0 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Spore_III_AB PF09548.10 ETO33228.1 - 5.3 7.1 12.0 4 7.5 1.6 2.9 2 1 1 3 3 3 0 Stage III sporulation protein AB (spore_III_AB) HEAT PF02985.22 ETO33229.1 - 1.8e-29 99.2 32.0 0.064 13.6 0.0 19.1 21 0 0 21 21 20 6 HEAT repeat HEAT_2 PF13646.6 ETO33229.1 - 1.5e-27 95.8 3.2 0.00037 20.8 0.0 13.9 8 4 6 14 14 14 7 HEAT repeats HEAT_EZ PF13513.6 ETO33229.1 - 1.9e-26 92.1 8.5 0.0081 16.6 0.0 14.9 13 3 3 16 16 14 5 HEAT-like repeat CLASP_N PF12348.8 ETO33229.1 - 5.7e-17 62.1 5.3 0.02 14.4 0.1 8.9 6 3 3 9 9 9 5 CLASP N terminal Vac14_Fab1_bd PF12755.7 ETO33229.1 - 1.9e-16 60.4 1.3 3.4 8.3 0.0 11.9 12 3 3 15 15 13 3 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETO33229.1 - 4.9e-14 52.7 19.5 0.0058 16.7 0.0 10.8 8 2 2 10 10 10 4 non-SMC mitotic condensation complex subunit 1 DUF3385 PF11865.8 ETO33229.1 - 8.7e-07 29.0 10.9 3.5 7.5 0.0 9.1 7 1 0 8 8 8 1 Domain of unknown function (DUF3385) UME PF08064.13 ETO33229.1 - 0.023 14.6 21.0 0.13 12.2 0.0 8.1 10 2 1 11 11 11 0 UME (NUC010) domain RTP1_C1 PF10363.9 ETO33229.1 - 0.027 14.6 0.4 1.7e+02 2.4 0.0 6.1 6 0 0 6 6 6 0 Required for nuclear transport of RNA pol II C-terminus 1 Cohesin_HEAT PF12765.7 ETO33229.1 - 0.035 14.4 4.3 6.5 7.2 0.0 5.5 4 1 0 4 4 4 0 HEAT repeat associated with sister chromatid cohesion NUC173 PF08161.12 ETO33229.1 - 0.049 13.3 0.0 0.66 9.6 0.0 3.2 1 0 0 1 1 1 0 NUC173 domain Arm PF00514.23 ETO33229.1 - 0.11 12.6 8.6 10 6.3 0.1 7.2 11 0 0 11 11 10 0 Armadillo/beta-catenin-like repeat DUF3446 PF11928.8 ETO33229.1 - 0.98 9.8 13.6 3.4 8.0 13.6 1.9 1 0 0 1 1 1 0 Early growth response N-terminal domain Spt20 PF12090.8 ETO33229.1 - 1.4 8.5 6.5 1.2 8.7 0.5 2.7 2 0 0 2 2 2 0 Spt20 family zf-TRAF PF02176.18 ETO33230.1 - 4.2e-06 27.3 3.0 4.2e-06 27.3 3.0 2.4 2 1 1 3 3 3 1 TRAF-type zinc finger DUF2205 PF10224.9 ETO33230.1 - 0.13 12.2 0.0 0.31 11.1 0.0 1.6 1 0 0 1 1 1 0 Short coiled-coil protein Peptidase_C14 PF00656.22 ETO33231.1 - 2.1e-16 60.6 0.9 3.1e-16 60.1 0.9 1.2 1 0 0 1 1 1 1 Caspase domain UCH PF00443.29 ETO33231.1 - 0.016 14.7 0.4 0.019 14.4 0.4 1.4 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolase WD40 PF00400.32 ETO33232.1 - 4.9e-123 397.4 56.4 3.3e-09 37.2 0.3 16.3 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33232.1 - 1.2e-28 99.2 18.2 0.13 12.6 0.0 13.4 1 1 14 15 15 15 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33232.1 - 1.4e-18 67.0 9.4 0.16 10.9 0.0 12.0 1 1 13 14 14 14 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33232.1 - 2.9e-18 66.2 27.0 0.00096 18.6 0.2 9.0 1 1 7 9 9 9 6 WD40-like domain DUF5046 PF16465.5 ETO33232.1 - 1.1e-08 34.9 0.2 0.2 11.1 0.0 5.1 2 2 1 4 4 4 3 Domain of unknown function (DUF5046) Pentapeptide PF00805.22 ETO33232.1 - 3.3e-07 29.8 0.6 7.5e-07 28.7 0.6 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) SGL PF08450.12 ETO33232.1 - 8.6e-05 22.2 1.1 0.77 9.3 0.1 4.4 2 2 0 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO33232.1 - 0.00015 20.5 11.7 0.038 12.5 0.2 5.1 4 2 1 6 6 6 2 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETO33232.1 - 0.00042 20.4 0.1 0.0012 18.9 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Str_synth PF03088.16 ETO33232.1 - 0.0016 18.5 2.1 13 5.9 0.0 6.3 7 1 1 8 8 8 0 Strictosidine synthase DUF4909 PF16253.5 ETO33232.1 - 0.0034 17.2 0.0 13 5.7 0.0 4.5 3 1 0 4 4 4 0 Domain of unknown function (DUF4909) PD40 PF07676.12 ETO33232.1 - 0.0036 17.2 20.5 10 6.2 0.0 8.9 11 0 0 11 11 11 1 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO33232.1 - 0.004 17.3 0.3 0.011 15.8 0.3 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) WD40_3 PF15911.5 ETO33232.1 - 0.08 13.0 0.1 1.8 8.6 0.0 3.4 3 0 0 3 3 3 0 WD domain, G-beta repeat Resistin PF06954.11 ETO33232.1 - 0.28 11.7 2.7 20 5.8 0.0 4.6 4 2 0 5 5 5 0 Resistin NACHT PF05729.12 ETO33233.1 - 5.2e-06 26.5 0.0 0.016 15.1 0.0 2.6 1 1 1 2 2 2 2 NACHT domain ABC_tran PF00005.27 ETO33233.1 - 0.0043 17.6 0.0 0.026 15.0 0.0 2.3 2 0 0 2 2 2 1 ABC transporter AAA_18 PF13238.6 ETO33233.1 - 0.0057 17.2 2.9 0.016 15.8 0.2 3.0 2 1 1 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO33233.1 - 0.0088 16.3 1.1 0.069 13.4 0.1 2.7 2 1 1 3 3 3 1 AAA domain RelA_SpoT PF04607.17 ETO33233.1 - 0.015 15.6 0.4 0.015 15.6 0.4 2.8 3 0 0 3 3 3 0 Region found in RelA / SpoT proteins RNA_helicase PF00910.22 ETO33233.1 - 0.039 14.3 1.1 0.18 12.2 0.0 2.7 3 0 0 3 3 3 0 RNA helicase TsaE PF02367.17 ETO33233.1 - 0.045 13.8 0.1 0.19 11.7 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETO33233.1 - 0.091 13.1 0.1 0.33 11.3 0.1 1.9 1 1 1 2 2 2 0 AAA ATPase domain RsgA_GTPase PF03193.16 ETO33233.1 - 0.11 12.4 0.0 0.4 10.6 0.0 2.0 1 0 0 1 1 1 0 RsgA GTPase ATPase PF06745.13 ETO33233.1 - 0.11 11.9 1.2 1.7 7.9 0.0 2.8 3 0 0 3 3 3 0 KaiC AAA_30 PF13604.6 ETO33233.1 - 0.11 12.2 0.0 0.22 11.2 0.0 1.4 1 0 0 1 1 1 0 AAA domain SLATT_5 PF18160.1 ETO33233.1 - 5.6 6.3 9.2 1 8.6 0.3 2.9 3 0 0 3 3 3 0 SMODS and SLOG-associating 2TM effector domain family 5 TUDOR PF00567.24 ETO33234.1 - 7.9e-10 38.8 0.1 1.4e-09 38.0 0.1 1.6 1 1 0 1 1 1 1 Tudor domain SMN PF06003.12 ETO33234.1 - 0.00093 18.5 0.1 0.0012 18.2 0.1 1.3 1 0 0 1 1 1 1 Survival motor neuron protein (SMN) ParB PF08775.10 ETO33234.1 - 0.098 13.1 0.3 0.098 13.1 0.3 2.0 3 0 0 3 3 3 0 ParB family RabGAP-TBC PF00566.18 ETO33235.1 - 8.7e-08 32.1 6.9 8.7e-08 32.1 6.9 2.1 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Glycos_transf_2 PF00535.26 ETO33236.1 - 0.003 17.4 0.0 0.0063 16.3 0.0 1.6 1 0 0 1 1 1 1 Glycosyl transferase family 2 MMS19_N PF14500.6 ETO33236.1 - 0.0083 15.7 0.1 0.59 9.7 0.0 3.0 3 1 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II UCH PF00443.29 ETO33237.1 - 3.5e-18 66.0 2.9 2e-17 63.5 2.6 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase zf-TRAF PF02176.18 ETO33237.1 - 1.3e-07 32.2 6.8 3.4e-07 30.9 1.0 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO33237.1 - 0.014 15.8 1.7 0.014 15.8 1.7 2.2 1 1 1 2 2 2 0 TRAF-like zinc-finger TAF1_subA PF14929.6 ETO33237.1 - 7.9 5.8 12.5 0.6 9.5 6.8 1.8 2 1 0 2 2 2 0 TAF RNA Polymerase I subunit A MBOAT PF03062.19 ETO33238.1 - 0.0037 16.7 0.6 0.0047 16.3 0.6 1.2 1 0 0 1 1 1 1 MBOAT, membrane-bound O-acyltransferase family Viral_Beta_CD PF04530.12 ETO33239.1 - 0.021 15.1 0.2 0.049 13.9 0.2 1.7 1 0 0 1 1 1 0 Viral Beta C/D like family NuiA PF07924.11 ETO33239.1 - 0.24 11.8 2.4 0.3 11.5 1.1 1.8 1 1 0 1 1 1 0 Nuclease A inhibitor-like protein THOC7 PF05615.13 ETO33239.1 - 0.83 9.9 4.4 0.58 10.4 0.8 2.1 2 0 0 2 2 2 0 Tho complex subunit 7 TPR_12 PF13424.6 ETO33240.1 - 1.2e-26 92.8 3.9 1.5e-08 34.8 0.0 4.6 3 2 2 5 5 5 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33240.1 - 9.9e-12 44.0 8.8 0.015 15.3 0.3 5.7 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33240.1 - 2.1e-10 40.0 12.9 0.001 18.8 0.0 6.5 7 1 0 7 7 7 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33240.1 - 3.6e-07 29.8 0.1 1.2 9.2 0.0 5.9 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33240.1 - 4.3e-07 29.6 12.7 0.011 15.9 0.0 5.7 7 0 0 7 7 6 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33240.1 - 7.8e-05 22.4 1.1 9.2 6.6 0.0 5.1 5 0 0 5 5 5 1 Tetratricopeptide repeat SNAP PF14938.6 ETO33240.1 - 9.5e-05 22.0 11.1 0.053 12.9 3.0 3.2 2 1 1 3 3 3 2 Soluble NSF attachment protein, SNAP SHNi-TPR PF10516.9 ETO33240.1 - 0.0004 19.8 0.1 0.23 10.9 0.0 3.7 4 0 0 4 4 4 1 SHNi-TPR SLT PF01464.20 ETO33240.1 - 0.0011 18.6 2.1 0.0016 18.1 0.3 2.0 2 0 0 2 2 2 1 Transglycosylase SLT domain TPR_6 PF13174.6 ETO33240.1 - 0.0012 19.3 3.2 51 4.8 0.0 5.3 6 0 0 6 6 5 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO33240.1 - 0.0014 18.1 0.1 0.014 14.8 0.0 2.0 1 1 1 2 2 2 1 MalT-like TPR region SPO22 PF08631.10 ETO33240.1 - 0.025 14.1 0.8 0.57 9.6 0.8 2.2 1 1 0 1 1 1 0 Meiosis protein SPO22/ZIP4 like TPR_14 PF13428.6 ETO33240.1 - 0.028 15.2 0.0 29 5.8 0.0 3.7 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33240.1 - 0.038 13.7 3.4 1.6 8.5 0.6 4.1 4 0 0 4 4 4 0 TPR repeat Sel1 PF08238.12 ETO33240.1 - 0.13 13.0 0.0 0.53 11.0 0.0 2.1 1 0 0 1 1 1 0 Sel1 repeat SecA_DEAD PF07517.14 ETO33241.1 - 9.3e-08 31.7 0.0 9.3e-08 31.7 0.0 4.9 4 1 1 5 5 5 1 SecA DEAD-like domain Helicase_C PF00271.31 ETO33241.1 - 0.0076 16.6 5.3 0.022 15.1 0.0 4.5 4 1 0 4 4 4 1 Helicase conserved C-terminal domain DUF3369 PF11849.8 ETO33241.1 - 0.085 13.1 4.7 0.63 10.2 0.3 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3369) DUF1108 PF06531.11 ETO33241.1 - 0.4 11.0 10.7 2.8 8.3 0.3 4.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1108) Helicase_C PF00271.31 ETO33242.1 - 4.6e-05 23.7 2.0 9e-05 22.8 0.1 2.5 3 0 0 3 3 3 1 Helicase conserved C-terminal domain CFAP91 PF14738.6 ETO33242.1 - 0.19 11.8 2.1 0.48 10.5 0.7 2.2 2 0 0 2 2 2 0 Cilia- and flagella-associated protein 91 SecA_DEAD PF07517.14 ETO33243.1 - 2.7e-07 30.2 0.0 2.7e-07 30.2 0.0 4.2 3 1 0 3 3 3 1 SecA DEAD-like domain AAA_19 PF13245.6 ETO33243.1 - 0.0034 17.7 0.5 0.026 14.8 0.1 2.9 2 0 0 2 2 2 1 AAA domain MMR_HSR1 PF01926.23 ETO33243.1 - 0.0045 17.0 4.8 0.0064 16.6 0.0 3.8 3 0 0 3 3 3 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO33243.1 - 0.0051 17.3 0.0 0.0051 17.3 0.0 5.0 3 1 0 3 3 3 1 ABC transporter RsgA_GTPase PF03193.16 ETO33243.1 - 0.0099 15.8 0.0 0.0099 15.8 0.0 4.1 3 0 0 3 3 3 1 RsgA GTPase AAA_29 PF13555.6 ETO33243.1 - 0.065 13.0 0.0 0.22 11.3 0.0 1.9 1 0 0 1 1 1 0 P-loop containing region of AAA domain ZZ PF00569.17 ETO33243.1 - 0.066 13.0 0.4 0.19 11.6 0.4 1.7 1 0 0 1 1 1 0 Zinc finger, ZZ type DUF4841 PF16129.5 ETO33243.1 - 0.1 12.9 0.0 0.56 10.5 0.0 2.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4841) AAA_22 PF13401.6 ETO33243.1 - 2.9 8.2 7.4 1.7 8.9 0.0 4.2 5 0 0 5 5 5 0 AAA domain PI_PP_I PF18363.1 ETO33243.1 - 6.3 7.0 8.2 15 5.8 0.0 6.2 5 0 0 5 5 5 0 Phosphoinositide phosphatase insertion domain VWA_2 PF13519.6 ETO33244.1 - 4e-06 27.4 0.0 1.1e-05 26.1 0.0 1.7 1 0 0 1 1 1 1 von Willebrand factor type A domain VWA_3 PF13768.6 ETO33244.1 - 0.019 14.9 0.1 2.5 8.0 0.1 2.9 1 1 0 1 1 1 0 von Willebrand factor type A domain Alpha-2-MRAP_N PF06400.11 ETO33244.1 - 0.038 14.0 0.5 0.085 12.9 0.5 1.7 1 0 0 1 1 1 0 Alpha-2-macroglobulin RAP, N-terminal domain AviRa PF11599.8 ETO33244.1 - 0.085 12.3 0.1 0.15 11.5 0.1 1.3 1 0 0 1 1 1 0 RRNA methyltransferase AviRa VWA_CoxE PF05762.14 ETO33244.1 - 0.1 12.0 0.0 3.3 7.0 0.0 2.1 2 0 0 2 2 2 0 VWA domain containing CoxE-like protein DUF2208 PF09973.9 ETO33245.1 - 0.036 13.7 5.1 0.054 13.1 5.1 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) U-box PF04564.15 ETO33246.1 - 1.8e-19 69.7 0.1 1.8e-19 69.7 0.1 2.2 3 0 0 3 3 3 1 U-box domain zf-NOSIP PF15906.5 ETO33246.1 - 4.1e-05 23.6 0.0 7.6e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETO33246.1 - 6.1e-05 22.7 0.0 0.00015 21.5 0.0 1.6 1 0 0 1 1 1 1 Zinc-finger of the MIZ type in Nse subunit IPK PF03770.16 ETO33246.1 - 0.0016 18.3 0.2 0.79 9.5 0.1 2.3 2 0 0 2 2 2 2 Inositol polyphosphate kinase HABP4_PAI-RBP1 PF04774.15 ETO33246.1 - 0.025 15.4 1.6 0.042 14.7 1.6 1.4 1 0 0 1 1 1 0 Hyaluronan / mRNA binding family DUF3764 PF12594.8 ETO33246.1 - 0.031 14.3 0.0 8.7 6.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3764) zf-RING_UBOX PF13445.6 ETO33246.1 - 0.15 12.1 0.0 0.35 10.9 0.0 1.7 1 0 0 1 1 1 0 RING-type zinc-finger Methyltransf_12 PF08242.12 ETO33246.1 - 0.16 12.7 1.2 0.4 11.4 1.2 1.7 1 0 0 1 1 1 0 Methyltransferase domain YfhO PF09586.10 ETO33246.1 - 4.1 5.5 12.0 5.3 5.1 12.0 1.1 1 0 0 1 1 1 0 Bacterial membrane protein YfhO PBP PF01161.20 ETO33247.1 - 2.1e-11 44.2 0.0 2.9e-11 43.8 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylethanolamine-binding protein Hist_deacetyl PF00850.19 ETO33248.1 - 2.1e-19 70.1 0.0 3.2e-19 69.6 0.0 1.2 1 0 0 1 1 1 1 Histone deacetylase domain DUF4918 PF16265.5 ETO33249.1 - 0.003 17.1 1.2 0.003 17.1 1.2 2.0 1 1 1 2 2 2 1 Domain of unknown function (DUF4918) Fas_alpha_ACP PF18325.1 ETO33250.1 - 0.16 12.3 0.1 2.2 8.6 0.0 2.6 3 0 0 3 3 3 0 Fatty acid synthase subunit alpha Acyl carrier domain UCH_1 PF13423.6 ETO33251.1 - 6.6e-11 42.4 0.1 1.3e-10 41.4 0.1 1.5 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH PF00443.29 ETO33251.1 - 2.6e-10 40.2 0.3 6.5e-10 38.9 0.3 1.7 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase BcsB PF03170.13 ETO33252.1 - 0.089 11.1 1.4 0.096 11.0 1.4 1.0 1 0 0 1 1 1 0 Bacterial cellulose synthase subunit LAMTOR5 PF16672.5 ETO33252.1 - 0.1 12.5 0.3 0.15 12.0 0.3 1.2 1 0 0 1 1 1 0 Ragulator complex protein LAMTOR5 WD40 PF00400.32 ETO33254.1 - 1.8e-12 47.6 5.5 0.0013 19.5 0.2 5.5 5 1 0 5 5 5 3 WD domain, G-beta repeat Endonuc_subdom PF09062.10 ETO33254.1 - 0.26 12.1 2.9 0.37 11.6 0.2 2.5 2 1 1 3 3 3 0 PI-PfuI Endonuclease subdomain WD40 PF00400.32 ETO33255.1 - 0.00066 20.4 0.1 0.25 12.3 0.0 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 ETO33256.1 - 6.2e-48 159.8 13.6 1.1e-09 38.7 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33256.1 - 1.7e-20 73.1 6.2 0.00073 19.8 0.1 6.5 2 1 4 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO33256.1 - 2.1e-12 47.3 0.9 3.6e-05 23.7 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO33256.1 - 5.4e-12 45.3 3.0 0.024 13.6 0.1 6.1 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33256.1 - 3.2e-11 42.6 2.1 0.00014 20.6 0.7 3.3 2 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33256.1 - 7e-08 32.1 9.9 0.0048 16.3 0.2 3.4 2 1 1 3 3 3 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO33256.1 - 2.5e-07 29.6 1.4 0.0034 16.0 0.1 2.7 1 1 0 2 2 2 2 Cytochrome D1 heme domain PQQ PF01011.21 ETO33256.1 - 1.2e-05 25.0 0.0 0.56 10.2 0.0 3.8 3 0 0 3 3 3 2 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO33256.1 - 2.8e-05 23.2 2.1 0.055 12.4 0.1 3.7 2 2 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain DPPIV_N PF00930.21 ETO33256.1 - 0.00075 18.3 0.2 0.17 10.6 0.0 3.3 1 1 2 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Str_synth PF03088.16 ETO33256.1 - 0.0028 17.7 0.2 9.3 6.5 0.0 3.8 3 1 0 3 3 3 1 Strictosidine synthase DUF5570 PF17731.1 ETO33256.1 - 0.0059 16.7 0.2 6.4 6.9 0.0 3.7 2 2 2 4 4 4 1 Family of unknown function (DUF5570) Frtz PF11768.8 ETO33256.1 - 0.0071 14.7 0.1 0.034 12.5 0.1 2.0 2 1 0 2 2 2 1 WD repeat-containing and planar cell polarity effector protein Fritz Fibrillarin_2 PF10113.9 ETO33256.1 - 0.022 13.4 0.6 0.032 12.9 0.6 1.2 1 0 0 1 1 1 0 Fibrillarin-like archaeal protein PD40 PF07676.12 ETO33256.1 - 0.027 14.4 9.2 13 5.8 0.1 5.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat V_ATPase_I PF01496.19 ETO33257.1 - 1.4 6.8 17.0 1.7 6.5 17.0 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family HEPN_Toprim_N PF18871.1 ETO33257.1 - 2.2 8.2 9.5 0.4 10.6 4.1 1.9 1 1 1 2 2 2 0 HEPN/Toprim N-terminal domain 1 Sas10_Utp3 PF04000.15 ETO33257.1 - 3 8.6 6.2 3.2 8.4 0.7 2.8 2 0 0 2 2 2 0 Sas10/Utp3/C1D family CCDC84 PF14968.6 ETO33257.1 - 3.9 7.0 12.6 5.6 6.5 12.6 1.1 1 0 0 1 1 1 0 Coiled coil protein 84 Exonuc_VII_L PF02601.15 ETO33257.1 - 4.4 6.8 12.9 5.5 6.5 12.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit Mod_r PF07200.13 ETO33257.1 - 7.2 6.7 22.4 11 6.1 22.4 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DDHD PF02862.17 ETO33257.1 - 8.7 6.4 9.6 17 5.5 9.7 1.4 1 1 0 1 1 1 0 DDHD domain WD40 PF00400.32 ETO33258.1 - 2.6e-14 53.4 11.1 8.1e-07 29.6 0.3 4.5 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33258.1 - 0.00042 19.1 1.1 0.14 10.7 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33258.1 - 0.0039 17.5 0.1 0.13 12.6 0.0 2.6 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain YpsA PF06908.11 ETO33258.1 - 0.046 13.7 0.3 0.076 13.0 0.3 1.4 1 0 0 1 1 1 0 YspA SLOG family Kelch_6 PF13964.6 ETO33259.1 - 0.015 15.5 0.1 15 6.1 0.0 4.1 5 0 0 5 5 5 0 Kelch motif RhoGAP-FF1 PF16512.5 ETO33259.1 - 0.029 15.0 0.6 0.071 13.8 0.6 1.6 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain Sporozoite_P67 PF05642.11 ETO33260.1 - 1.8 6.6 8.8 2.4 6.1 8.8 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen ALMT PF11744.8 ETO33260.1 - 2.3 7.0 15.2 0.25 10.1 10.5 1.6 2 0 0 2 2 2 0 Aluminium activated malate transporter DUF2228 PF10228.9 ETO33260.1 - 4.3 7.0 11.6 2.3 7.9 6.6 2.2 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) GCD14 PF08704.10 ETO33260.1 - 6.4 6.4 10.1 1.2 8.7 5.8 1.9 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit RBFA PF02033.18 ETO33262.1 - 0.091 13.2 2.4 1 9.8 0.4 2.6 1 1 1 2 2 2 0 Ribosome-binding factor A PUB PF09409.10 ETO33264.1 - 0.0018 18.2 0.6 0.0018 18.2 0.6 2.4 1 1 1 2 2 2 1 PUB domain CW_binding_1 PF01473.20 ETO33264.1 - 0.097 13.0 1.7 0.097 13.0 1.7 2.6 3 0 0 3 3 3 0 Putative cell wall binding repeat Staphopain_pro PF14731.6 ETO33264.1 - 0.75 9.8 7.9 0.33 10.9 1.1 2.3 2 0 0 2 2 2 0 Staphopain proregion RRM_1 PF00076.22 ETO33265.1 - 3.3e-15 55.7 0.3 1.4e-14 53.6 0.1 2.1 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO33265.1 - 0.0012 18.7 0.4 0.0044 17.0 0.1 1.9 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_7 PF16367.5 ETO33265.1 - 0.01 15.9 0.5 0.023 14.8 0.1 1.7 1 1 1 2 2 2 0 RNA recognition motif RRM_5 PF13893.6 ETO33265.1 - 0.017 14.7 0.0 0.021 14.4 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO33265.1 - 0.025 14.4 0.0 0.046 13.6 0.0 1.4 1 0 0 1 1 1 0 Occluded RNA-recognition motif Corazonin PF17308.2 ETO33265.1 - 0.082 13.3 3.8 0.11 12.9 3.8 1.2 1 0 0 1 1 1 0 Pro-corazonin Cellulose_synt PF03552.14 ETO33265.1 - 0.14 10.6 2.5 0.15 10.5 2.5 1.0 1 0 0 1 1 1 0 Cellulose synthase Connexin PF00029.19 ETO33265.1 - 0.21 11.3 2.2 0.25 11.1 2.2 1.1 1 0 0 1 1 1 0 Connexin Smg4_UPF3 PF03467.15 ETO33265.1 - 1.6 8.7 14.1 12 5.8 0.1 2.1 1 1 1 2 2 2 0 Smg-4/UPF3 family OATP PF03137.20 ETO33265.1 - 1.9 6.7 3.5 2.3 6.4 3.5 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Med7 PF05983.11 ETO33266.1 - 9.4e-07 29.1 17.1 1.8e-05 24.9 6.9 2.5 1 1 1 2 2 2 2 MED7 protein ACP_syn_III_C PF08541.10 ETO33266.1 - 0.059 13.5 0.8 3.6 7.8 0.1 2.2 2 0 0 2 2 2 0 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal YlbD_coat PF14071.6 ETO33266.1 - 0.13 12.5 3.0 0.21 11.9 2.7 1.5 1 1 0 1 1 1 0 Putative coat protein Spt5-NGN PF03439.13 ETO33267.1 - 1.5e-09 37.6 0.0 3.3e-09 36.5 0.0 1.6 1 0 0 1 1 1 1 Early transcription elongation factor of RNA pol II, NGN section SARAF PF06682.12 ETO33267.1 - 0.0082 15.8 0.5 0.011 15.4 0.5 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis UCH_C PF18031.1 ETO33267.1 - 0.14 12.1 3.6 0.47 10.4 3.6 1.9 1 0 0 1 1 1 0 Ubiquitin carboxyl-terminal hydrolases Mucin PF01456.17 ETO33267.1 - 0.33 11.0 8.3 3.5 7.6 8.4 2.1 1 1 0 1 1 1 0 Mucin-like glycoprotein WD40 PF00400.32 ETO33268.1 - 2.3e-42 142.2 26.6 3e-08 34.2 0.1 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33268.1 - 1.6e-15 57.1 0.7 0.014 15.6 0.0 5.8 6 1 0 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33268.1 - 7.5e-07 28.2 3.9 1.6 7.3 0.0 5.7 3 2 3 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33268.1 - 2.4e-06 27.1 1.4 0.8 9.0 0.0 4.5 1 1 4 5 5 5 2 WD40-like domain Img2 PF05046.14 ETO33270.1 - 0.033 14.5 0.0 0.084 13.2 0.0 1.7 1 0 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) PPR PF01535.20 ETO33271.1 - 5.6e-09 35.7 6.3 0.00025 21.1 0.1 4.0 4 0 0 4 4 4 3 PPR repeat PPR_2 PF13041.6 ETO33271.1 - 1.3e-08 34.8 6.5 0.0011 19.1 0.0 4.8 5 0 0 5 5 5 2 PPR repeat family PPR_1 PF12854.7 ETO33271.1 - 0.00055 19.6 0.1 0.031 14.0 0.0 3.1 3 0 0 3 3 3 1 PPR repeat DUF1838 PF08894.11 ETO33271.1 - 0.022 14.5 1.7 0.067 12.9 1.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1838) PPR_3 PF13812.6 ETO33271.1 - 0.029 14.4 1.1 0.54 10.4 0.1 3.3 3 1 1 4 4 4 0 Pentatricopeptide repeat domain CAMSAP_CC1 PF17095.5 ETO33271.1 - 1.2 9.0 6.7 0.42 10.5 3.0 2.1 2 0 0 2 2 2 0 Spectrin-binding region of Ca2+-Calmodulin VWA_3 PF13768.6 ETO33272.1 - 0.03 14.3 0.0 0.33 10.9 0.0 2.1 1 1 0 1 1 1 0 von Willebrand factor type A domain SPATA19 PF15212.6 ETO33272.1 - 0.051 13.8 0.0 0.075 13.2 0.0 1.3 1 0 0 1 1 1 0 Spermatogenesis-associated protein 19, mitochondrial BORA_N PF15280.6 ETO33272.1 - 0.059 13.0 0.0 0.074 12.7 0.0 1.1 1 0 0 1 1 1 0 Protein aurora borealis N-terminus MoeA_N PF03453.17 ETO33274.1 - 1.5e-24 86.6 0.1 1.8e-24 86.3 0.1 1.1 1 0 0 1 1 1 1 MoeA N-terminal region (domain I and II) Glyco_hydro_47 PF01532.20 ETO33275.1 - 3.1e-94 316.5 6.3 5.7e-94 315.6 6.3 1.4 1 1 0 1 1 1 1 Glycosyl hydrolase family 47 WD40 PF00400.32 ETO33280.1 - 4.7e-07 30.4 3.6 1.3e-05 25.8 0.5 3.1 2 2 0 2 2 2 1 WD domain, G-beta repeat Utp8 PF10395.9 ETO33280.1 - 0.1 11.1 0.0 0.1 11.1 0.0 1.0 1 0 0 1 1 1 0 Utp8 family SDA1 PF05285.12 ETO33281.1 - 0.23 10.8 22.4 0.27 10.6 22.4 1.1 1 0 0 1 1 1 0 SDA1 BUD22 PF09073.10 ETO33281.1 - 0.62 9.3 19.6 0.72 9.1 19.6 1.1 1 0 0 1 1 1 0 BUD22 Nop14 PF04147.12 ETO33281.1 - 1.7 6.8 23.9 2.1 6.5 23.9 1.1 1 0 0 1 1 1 0 Nop14-like family PPP4R2 PF09184.11 ETO33281.1 - 7.8 6.0 25.0 13 5.3 25.0 1.4 1 0 0 1 1 1 0 PPP4R2 WD40 PF00400.32 ETO33282.1 - 5.3e-32 109.4 22.5 8.3e-07 29.6 0.9 7.4 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33282.1 - 2.7e-13 50.0 2.5 0.0043 17.3 0.0 5.8 5 2 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33282.1 - 4.8e-12 45.3 3.3 0.023 13.4 0.0 5.8 1 1 4 6 6 6 5 Nucleoporin Nup120/160 Tuberin PF03542.16 ETO33283.1 - 0.036 13.2 0.0 0.045 12.9 0.0 1.1 1 0 0 1 1 1 0 Tuberin Amidase PF01425.21 ETO33284.1 - 5e-12 45.5 0.0 4.6e-10 39.0 0.0 2.0 2 0 0 2 2 2 2 Amidase TPR_2 PF07719.17 ETO33285.1 - 1.4e-15 56.0 4.5 0.00053 19.9 0.1 5.2 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33285.1 - 2.7e-14 52.3 15.2 7.4e-07 28.7 0.2 5.3 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33285.1 - 1.2e-10 40.7 13.1 0.00019 21.4 0.1 5.6 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33285.1 - 5.8e-09 35.7 7.7 0.014 15.7 0.0 5.3 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33285.1 - 3.5e-07 29.8 9.0 0.0025 17.5 1.1 4.1 3 1 1 4 4 4 2 TPR repeat TPR_16 PF13432.6 ETO33285.1 - 5.9e-07 30.0 0.0 0.0011 19.6 0.0 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO33285.1 - 0.00011 22.6 3.7 0.016 15.7 0.1 3.6 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33285.1 - 0.00013 22.5 0.1 1.6 9.7 0.0 4.2 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33285.1 - 0.00085 19.2 0.4 0.85 9.8 0.0 3.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO33285.1 - 0.0012 19.1 3.0 0.33 11.3 0.6 4.4 2 1 3 5 5 5 2 Tetratricopeptide repeat TPR_20 PF14561.6 ETO33285.1 - 0.0072 16.6 1.6 0.48 10.8 0.7 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_15 PF13429.6 ETO33285.1 - 0.0091 15.2 0.1 0.027 13.7 0.1 1.8 2 0 0 2 2 2 1 Tetratricopeptide repeat BTAD PF03704.17 ETO33285.1 - 0.0097 16.3 0.0 0.028 14.8 0.0 1.8 1 0 0 1 1 1 1 Bacterial transcriptional activator domain TPR_6 PF13174.6 ETO33285.1 - 0.02 15.5 0.0 53 4.8 0.0 4.8 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF627 PF04781.12 ETO33285.1 - 0.027 14.5 0.4 0.094 12.7 0.4 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF627) MIT PF04212.18 ETO33285.1 - 0.028 14.5 4.3 2.3 8.3 1.7 3.8 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Macoilin PF09726.9 ETO33285.1 - 0.058 12.0 12.3 0.083 11.4 12.3 1.3 1 0 0 1 1 1 0 Macoilin family TPR_9 PF13371.6 ETO33285.1 - 0.095 12.9 0.0 4.1 7.6 0.0 3.0 3 1 1 4 4 3 0 Tetratricopeptide repeat ERG4_ERG24 PF01222.17 ETO33286.1 - 6.7e-77 259.1 20.8 7.9e-77 258.8 20.8 1.0 1 0 0 1 1 1 1 Ergosterol biosynthesis ERG4/ERG24 family DUF1295 PF06966.12 ETO33286.1 - 2.1e-07 30.7 3.3 3.2e-07 30.1 3.3 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ETO33286.1 - 0.0039 17.6 0.0 0.0095 16.3 0.0 1.7 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF4293 PF14126.6 ETO33286.1 - 0.19 12.0 2.5 0.55 10.5 2.4 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4293) Ribosomal_L22e PF01776.17 ETO33287.1 - 0.24 11.8 4.4 0.11 12.9 2.2 1.7 2 0 0 2 2 2 0 Ribosomal L22e protein family DUF494 PF04361.13 ETO33288.1 - 0.02 14.8 0.2 0.029 14.3 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF494) Vpu PF00558.19 ETO33288.1 - 0.021 14.6 0.2 0.039 13.7 0.2 1.4 1 0 0 1 1 1 0 Vpu protein polyprenyl_synt PF00348.17 ETO33288.1 - 0.12 11.4 1.0 0.22 10.5 0.5 1.5 1 1 0 1 1 1 0 Polyprenyl synthetase WD40 PF00400.32 ETO33289.1 - 1.7e-06 28.6 0.1 0.12 13.2 0.0 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33289.1 - 1.6e-05 25.1 0.2 0.0042 17.4 0.1 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain ATE_C PF04377.15 ETO33289.1 - 0.037 14.6 0.0 0.049 14.3 0.0 1.3 1 0 0 1 1 1 0 Arginine-tRNA-protein transferase, C terminus FAM199X PF15814.5 ETO33290.1 - 0.0068 15.5 12.7 0.008 15.3 12.7 1.0 1 0 0 1 1 1 1 Protein family FAM199X CDK2AP PF09806.9 ETO33290.1 - 0.012 15.7 13.0 0.013 15.6 13.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase 2-associated protein PI3K_1B_p101 PF10486.9 ETO33290.1 - 0.092 10.5 17.3 0.1 10.4 17.3 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit ICAP-1_inte_bdg PF10480.9 ETO33290.1 - 0.12 12.4 8.9 0.16 12.0 8.9 1.1 1 0 0 1 1 1 0 Beta-1 integrin binding protein SR-25 PF10500.9 ETO33290.1 - 0.13 11.9 28.9 2.4 7.7 28.9 2.0 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein DUF4698 PF15769.5 ETO33290.1 - 0.34 9.9 11.0 0.38 9.7 11.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4698) DUF2457 PF10446.9 ETO33290.1 - 0.41 9.7 14.9 0.47 9.6 14.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) SMYLE_N PF18615.1 ETO33290.1 - 0.65 9.5 10.8 0.75 9.3 10.8 1.1 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain ASD2 PF08687.11 ETO33290.1 - 0.71 9.4 13.1 0.9 9.0 13.1 1.1 1 0 0 1 1 1 0 Apx/Shroom domain ASD2 Menin PF05053.13 ETO33290.1 - 0.94 7.8 14.1 1.2 7.4 14.1 1.3 1 0 0 1 1 1 0 Menin NST1 PF13945.6 ETO33290.1 - 1 9.4 21.0 1.2 9.2 21.0 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator TFIIF_alpha PF05793.12 ETO33290.1 - 4.8 5.7 20.3 5.2 5.5 20.3 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) Corona_nucleoca PF00937.18 ETO33290.1 - 5.4 5.9 14.8 6.3 5.7 14.8 1.1 1 0 0 1 1 1 0 Coronavirus nucleocapsid protein Sporozoite_P67 PF05642.11 ETO33290.1 - 5.8 4.9 17.5 6.4 4.7 17.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen SWI-SNF_Ssr4 PF08549.10 ETO33290.1 - 7.6 5.0 13.5 8.1 4.9 13.5 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Apt1 PF10351.9 ETO33290.1 - 7.9 5.2 22.5 9 5.0 22.5 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain Peptidase_S64 PF08192.11 ETO33290.1 - 8.9 4.7 18.0 10 4.5 18.0 1.0 1 0 0 1 1 1 0 Peptidase family S64 PRP21_like_P PF12230.8 ETO33291.1 - 2e-24 86.7 11.3 2e-13 50.7 1.1 2.7 1 1 1 2 2 2 2 Pre-mRNA splicing factor PRP21 like protein MID_MedPIWI PF18296.1 ETO33291.1 - 0.007 16.2 6.6 0.79 9.5 2.9 2.2 2 0 0 2 2 2 2 MID domain of medPIWI DUF3439 PF11921.8 ETO33291.1 - 0.02 14.8 3.4 0.045 13.7 3.4 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Mucin PF01456.17 ETO33291.1 - 0.24 11.4 11.8 0.52 10.3 11.8 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF4834 PF16118.5 ETO33291.1 - 2.5 9.1 11.7 2.6 9.0 4.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Rootletin PF15035.6 ETO33292.1 - 0.00018 21.6 3.6 0.0003 20.9 3.6 1.2 1 0 0 1 1 1 1 Ciliary rootlet component, centrosome cohesion PikAIV_N PF18605.1 ETO33292.1 - 0.0047 16.5 4.6 0.0048 16.5 0.4 2.7 2 1 1 3 3 3 1 Narbonolide/10-deoxymethynolide synthase PikA4 N-terminal domain HALZ PF02183.18 ETO33292.1 - 0.095 12.9 0.6 0.47 10.7 0.2 2.0 2 0 0 2 2 2 0 Homeobox associated leucine zipper YabA PF06156.13 ETO33292.1 - 0.2 12.3 1.6 0.32 11.6 1.6 1.5 1 0 0 1 1 1 0 Initiation control protein YabA CENP-H PF05837.12 ETO33292.1 - 0.27 11.7 4.1 0.49 10.8 4.1 1.4 1 0 0 1 1 1 0 Centromere protein H (CENP-H) Macoilin PF09726.9 ETO33292.1 - 2.9 6.3 6.1 3.7 6.0 6.1 1.1 1 0 0 1 1 1 0 Macoilin family TMEM154 PF15102.6 ETO33293.1 - 0.0001 22.2 0.2 0.00014 21.8 0.2 1.2 1 0 0 1 1 1 1 TMEM154 protein family SKG6 PF08693.10 ETO33293.1 - 0.00036 19.9 3.1 0.00066 19.0 3.1 1.4 1 0 0 1 1 1 1 Transmembrane alpha-helix domain DAG1 PF05454.11 ETO33293.1 - 0.0017 17.8 0.1 0.002 17.5 0.1 1.2 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) DUF4448 PF14610.6 ETO33293.1 - 0.0033 17.2 0.0 0.0043 16.9 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF4448) CD34_antigen PF06365.12 ETO33293.1 - 0.0038 16.8 0.0 0.0041 16.7 0.0 1.2 1 0 0 1 1 1 1 CD34/Podocalyxin family DUF1180 PF06679.12 ETO33293.1 - 0.0061 17.0 0.1 0.0071 16.8 0.1 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1180) EphA2_TM PF14575.6 ETO33293.1 - 0.0085 16.9 0.1 0.02 15.8 0.1 1.6 1 0 0 1 1 1 1 Ephrin type-A receptor 2 transmembrane domain Adeno_E3_CR2 PF02439.15 ETO33293.1 - 0.011 15.5 0.5 0.018 14.8 0.5 1.3 1 0 0 1 1 1 0 Adenovirus E3 region protein CR2 COX6C PF02937.15 ETO33293.1 - 0.016 15.3 0.1 0.05 13.7 0.0 1.8 2 0 0 2 2 2 0 Cytochrome c oxidase subunit VIc DUF2615 PF11027.8 ETO33293.1 - 0.017 15.2 0.1 0.15 12.2 0.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2615) DUF4381 PF14316.6 ETO33293.1 - 0.031 14.5 0.0 0.066 13.4 0.0 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4381) Orf78 PF06024.12 ETO33293.1 - 0.032 14.5 0.0 0.048 14.0 0.0 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DUF4366 PF14283.6 ETO33293.1 - 0.04 14.0 0.0 0.064 13.3 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4366) Peptidase_M56 PF05569.11 ETO33293.1 - 0.051 12.8 0.1 0.067 12.4 0.1 1.2 1 0 0 1 1 1 0 BlaR1 peptidase M56 TMEM51 PF15345.6 ETO33293.1 - 0.053 13.4 0.1 0.069 13.0 0.1 1.2 1 0 0 1 1 1 0 Transmembrane protein 51 DUF4231 PF14015.6 ETO33293.1 - 0.053 14.0 0.0 0.079 13.4 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4231) Antimicrobial_7 PF08102.11 ETO33293.1 - 0.093 13.0 0.0 0.25 11.6 0.0 1.7 1 0 0 1 1 1 0 Scorpion antimicrobial peptide Insulin_TMD PF17870.1 ETO33293.1 - 0.1 12.7 0.2 0.25 11.5 0.2 1.6 1 0 0 1 1 1 0 Insulin receptor trans-membrane segment DUF443 PF04276.12 ETO33293.1 - 0.12 12.2 0.1 0.16 11.8 0.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF443) ETRAMP PF09716.10 ETO33293.1 - 0.24 11.5 4.1 0.11 12.6 1.3 1.7 1 1 1 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) Ctr PF04145.15 ETO33294.1 - 0.78 10.4 4.7 0.43 11.2 0.3 2.1 2 0 0 2 2 2 0 Ctr copper transporter family SNAP PF14938.6 ETO33295.1 - 2.1e-16 60.2 3.7 2.2e-16 60.1 3.7 1.0 1 0 0 1 1 1 1 Soluble NSF attachment protein, SNAP PPR_2 PF13041.6 ETO33295.1 - 0.00046 20.3 0.1 0.0015 18.7 0.0 1.8 3 0 0 3 3 3 1 PPR repeat family MIT PF04212.18 ETO33295.1 - 0.01 15.9 1.0 3.1 7.9 0.3 2.8 1 1 1 2 2 2 0 MIT (microtubule interacting and transport) domain NSF PF02071.20 ETO33295.1 - 0.022 15.4 2.9 3.3 8.9 0.1 4.1 4 1 0 4 4 4 0 Aromatic-di-Alanine (AdAR) repeat TPR_2 PF07719.17 ETO33295.1 - 0.075 13.2 3.4 13 6.2 0.1 3.6 2 2 2 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33295.1 - 0.1 12.4 2.7 18 5.4 0.1 3.4 3 1 1 4 4 4 0 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO33296.1 - 1.3e-08 35.2 4.3 2.4e-08 34.2 1.8 2.1 1 1 0 2 2 2 1 Caspase domain YqzH PF14164.6 ETO33296.1 - 0.017 15.2 3.6 1.4 9.0 0.1 3.9 3 1 0 3 3 3 0 YqzH-like protein Kelch_4 PF13418.6 ETO33296.1 - 0.13 12.3 0.9 4.6 7.3 0.0 2.9 2 1 1 3 3 3 0 Galactose oxidase, central domain DUF3853 PF12964.7 ETO33297.1 - 0.098 12.8 0.7 0.18 12.0 0.0 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF3853) SIR2 PF02146.17 ETO33297.1 - 0.13 12.2 0.3 0.13 12.2 0.3 2.0 2 0 0 2 2 2 0 Sir2 family Pal1 PF08316.11 ETO33297.1 - 5.5 7.7 7.1 1 10.1 0.7 2.2 1 1 1 2 2 2 0 Pal1 cell morphology protein Ank_4 PF13637.6 ETO33298.1 - 4.2e-07 30.4 0.3 0.0019 18.8 0.0 3.4 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO33298.1 - 2.2e-06 28.2 0.1 1.7e-05 25.3 0.0 2.3 2 1 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO33298.1 - 0.00019 21.6 0.4 1.2 9.9 0.1 3.1 3 0 0 3 3 3 2 Ankyrin repeat Ank PF00023.30 ETO33298.1 - 0.00023 21.5 0.1 0.0031 17.9 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO33298.1 - 0.025 14.9 2.5 0.065 13.6 0.1 2.8 3 1 0 3 3 3 0 Ankyrin repeats (many copies) Rtf2 PF04641.12 ETO33298.1 - 3.5 6.9 11.3 5.2 6.3 11.3 1.3 1 0 0 1 1 1 0 Rtf2 RING-finger RabGAP-TBC PF00566.18 ETO33299.1 - 0.15 11.6 1.8 0.17 11.5 1.8 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain Elongin_A PF06881.11 ETO33299.1 - 0.16 12.5 4.0 0.18 12.3 4.0 1.1 1 0 0 1 1 1 0 RNA polymerase II transcription factor SIII (Elongin) subunit A FAM163 PF15069.6 ETO33299.1 - 0.32 11.4 2.0 0.39 11.2 2.0 1.1 1 0 0 1 1 1 0 FAM163 family DUF3409 PF11889.8 ETO33300.1 - 0.11 12.5 0.2 0.2 11.6 0.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF3409) Spore_III_AF PF09581.10 ETO33301.1 - 0.012 15.6 1.3 0.012 15.6 1.3 1.1 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) PH_4 PF15404.6 ETO33301.1 - 0.044 13.6 2.6 0.048 13.5 2.6 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain TMEM215 PF15746.5 ETO33301.1 - 0.13 11.7 2.4 0.17 11.3 2.4 1.1 1 0 0 1 1 1 0 TMEM215 family Tau95_N PF17682.1 ETO33301.1 - 0.15 12.3 2.7 0.21 11.8 2.7 1.2 1 0 0 1 1 1 0 Tau95 Triple barrel domain Presenilin PF01080.17 ETO33301.1 - 2.3 6.9 3.0 2 7.1 3.0 1.0 1 0 0 1 1 1 0 Presenilin MscS_TM PF12794.7 ETO33301.1 - 4.1 6.2 4.0 4.7 6.0 4.0 1.0 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Kelch_4 PF13418.6 ETO33303.1 - 4.3e-05 23.4 0.1 0.0015 18.5 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO33303.1 - 6.8e-05 22.7 1.1 0.071 13.1 0.1 3.4 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO33303.1 - 0.00057 19.4 0.3 0.017 14.7 0.1 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO33303.1 - 0.0013 18.9 1.1 0.13 12.6 0.1 3.4 3 1 1 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO33303.1 - 0.055 13.5 4.5 0.5 10.4 0.2 3.4 4 0 0 4 4 4 0 Kelch motif Peptidase_M24_C PF16188.5 ETO33303.1 - 0.12 12.5 1.3 0.62 10.2 0.0 2.7 3 0 0 3 3 3 0 C-terminal region of peptidase_M24 WD40 PF00400.32 ETO33304.1 - 3e-31 107.0 25.5 1.2e-05 25.9 0.6 7.6 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO33304.1 - 6.5e-13 48.2 4.2 0.0046 15.7 0.0 5.1 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33304.1 - 4.7e-10 39.6 6.6 1.4 9.3 0.0 6.3 6 1 1 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO33304.1 - 6.5e-05 22.9 2.6 0.27 11.3 0.1 4.7 2 2 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF2730 PF10805.8 ETO33304.1 - 0.28 11.3 4.0 0.51 10.5 4.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2730) HIP1_clath_bdg PF16515.5 ETO33304.1 - 0.32 11.6 10.3 10 6.8 9.6 2.4 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 Phage_HK97_TLTM PF06120.11 ETO33304.1 - 1.4 8.1 9.1 2 7.5 9.1 1.2 1 0 0 1 1 1 0 Tail length tape measure protein DUF4407 PF14362.6 ETO33304.1 - 2.5 7.4 4.9 3.5 6.9 4.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF723 PF05265.13 ETO33305.1 - 0.13 12.2 1.2 0.17 11.8 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF723) zf-C3HC4_2 PF13923.6 ETO33305.1 - 0.44 10.4 6.2 1.8 8.5 3.4 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) AMP-binding PF00501.28 ETO33306.1 - 2.8e-38 131.6 0.0 3.8e-38 131.2 0.0 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO33306.1 - 0.00071 20.5 0.0 0.0024 18.8 0.0 2.0 1 1 1 2 2 2 1 AMP-binding enzyme C-terminal domain DnaI_N PF07319.11 ETO33306.1 - 0.26 12.0 1.2 1.4 9.6 1.2 2.1 1 1 0 1 1 1 0 Primosomal protein DnaI N-terminus Ribosomal_L3 PF00297.22 ETO33307.1 - 0.00082 18.4 2.4 0.00091 18.3 0.0 1.9 2 0 0 2 2 2 1 Ribosomal protein L3 SpoIIIAH PF12685.7 ETO33307.1 - 0.0045 16.9 3.0 0.0056 16.5 3.0 1.1 1 0 0 1 1 1 1 SpoIIIAH-like protein Sec62 PF03839.16 ETO33307.1 - 0.027 14.0 5.8 0.032 13.7 5.8 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 RR_TM4-6 PF06459.12 ETO33307.1 - 0.044 13.6 12.5 0.055 13.3 12.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO33307.1 - 0.11 11.2 3.2 0.12 11.1 3.2 1.1 1 0 0 1 1 1 0 Presenilin CDC45 PF02724.14 ETO33307.1 - 6.8 4.9 11.0 7.9 4.6 11.0 1.0 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO33308.1 - 8.6e-57 187.8 21.5 9.1e-11 42.2 0.0 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33308.1 - 4.4e-20 71.8 2.6 0.0006 20.1 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33308.1 - 8.5e-12 44.7 1.7 0.065 12.2 0.0 5.8 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33308.1 - 4e-11 42.8 1.0 0.0027 17.1 0.1 3.4 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO33308.1 - 3.6e-09 35.8 4.5 0.42 9.2 0.3 5.8 1 1 5 6 6 6 4 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO33308.1 - 1.4e-08 34.8 0.3 0.0092 15.9 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Cytochrom_D1 PF02239.16 ETO33308.1 - 5.2e-05 21.9 0.9 0.017 13.7 0.1 2.8 1 1 3 4 4 4 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO33308.1 - 0.00065 19.6 4.8 8.6 6.4 0.1 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat TolB_N PF04052.13 ETO33308.1 - 0.022 14.9 0.2 45 4.3 0.0 4.4 5 0 0 5 5 5 0 TolB amino-terminal domain HPS6 PF15702.5 ETO33308.1 - 0.034 12.2 0.0 1.1 7.2 0.0 2.8 2 1 2 4 4 4 0 Hermansky-Pudlak syndrome 6 protein PQQ PF01011.21 ETO33308.1 - 0.044 13.7 0.0 41 4.3 0.0 3.9 4 0 0 4 4 4 0 PQQ enzyme repeat Mid2 PF04478.12 ETO33308.1 - 0.047 13.5 3.8 55 3.6 0.1 4.4 4 1 0 4 4 4 0 Mid2 like cell wall stress sensor Proteasome_A_N PF10584.9 ETO33308.1 - 2.2 8.0 7.4 35 4.2 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature TPR_12 PF13424.6 ETO33309.1 - 1.5e-21 76.4 0.1 6.4e-12 45.6 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33309.1 - 2.9e-14 52.2 14.5 7.3e-08 31.9 0.3 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33309.1 - 9.8e-13 47.2 1.7 1.3e-06 28.0 0.0 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33309.1 - 1.2e-10 40.6 7.9 0.00015 21.6 0.0 4.4 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33309.1 - 4.1e-09 35.9 13.2 0.00015 21.7 0.1 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33309.1 - 6.1e-09 35.5 0.0 5.6e-05 22.9 0.0 4.1 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO33309.1 - 5.1e-06 26.1 0.0 2.1e-05 24.1 0.0 1.6 1 1 1 2 2 2 2 MalT-like TPR region TPR_11 PF13414.6 ETO33309.1 - 1.7e-05 24.4 8.4 0.0066 16.1 0.0 4.4 3 1 1 4 4 4 1 TPR repeat TPR_6 PF13174.6 ETO33309.1 - 7.8e-05 23.1 0.5 2.2 9.1 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat SNAP PF14938.6 ETO33309.1 - 0.00018 21.0 3.7 0.0011 18.5 1.0 2.2 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 ETO33309.1 - 0.00028 20.7 2.8 0.19 11.4 0.2 2.6 1 1 1 2 2 2 2 26S proteasome subunit RPN7 TPR_17 PF13431.6 ETO33309.1 - 0.0012 19.1 0.6 0.15 12.5 0.1 3.0 2 0 0 2 2 2 1 Tetratricopeptide repeat MIT PF04212.18 ETO33309.1 - 0.0012 18.8 3.0 0.89 9.7 0.2 3.4 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO33309.1 - 0.027 14.2 5.4 0.17 11.6 0.7 2.6 1 1 1 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 ETO33309.1 - 0.22 12.1 0.5 13 6.4 0.0 3.1 2 1 1 3 3 3 0 Tetratricopeptide repeat PPR_long PF17177.4 ETO33309.1 - 0.5 9.7 3.0 0.78 9.1 1.1 2.1 2 1 0 3 3 3 0 Pentacotripeptide-repeat region of PRORP TPR_3 PF07720.12 ETO33309.1 - 1.5 8.9 0.0 1.5 8.9 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat Prominin PF05478.11 ETO33312.1 - 0.0034 15.4 7.1 0.0067 14.4 7.1 1.4 1 0 0 1 1 1 1 Prominin Senescence PF06911.12 ETO33312.1 - 0.053 13.8 6.0 1.4 9.2 1.4 2.3 1 1 1 2 2 2 0 Senescence-associated protein FANCI_S2 PF14676.6 ETO33312.1 - 0.089 13.1 0.4 0.2 12.0 0.4 1.5 1 0 0 1 1 1 0 FANCI solenoid 2 DUF948 PF06103.11 ETO33312.1 - 0.17 12.1 20.0 0.1 12.9 8.9 3.0 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF885 PF05960.11 ETO33312.1 - 0.22 11.1 6.2 0.44 10.1 6.2 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF885) DASH_Duo1 PF08651.10 ETO33312.1 - 0.3 10.9 7.0 0.85 9.4 0.9 2.8 2 1 0 2 2 2 0 DASH complex subunit Duo1 AF-4 PF05110.13 ETO33312.1 - 0.36 8.9 21.7 0.54 8.3 21.7 1.2 1 0 0 1 1 1 0 AF-4 proto-oncoprotein TMP_2 PF06791.13 ETO33312.1 - 2.3 7.9 4.3 3.4 7.3 0.7 2.2 1 1 1 2 2 2 0 Prophage tail length tape measure protein HisKA_3 PF07730.13 ETO33312.1 - 2.6 8.6 5.6 2.8 8.5 0.3 3.3 1 1 2 3 3 3 0 Histidine kinase Tweety PF04906.13 ETO33312.1 - 3.3 6.3 9.4 1.8 7.2 4.6 2.3 1 1 1 2 2 2 0 Tweety DUF883 PF05957.13 ETO33312.1 - 4.8 7.9 14.8 3.2 8.4 6.4 3.0 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF883) Goodbye PF17109.5 ETO33312.1 - 5.6 7.4 7.3 8.4 6.9 0.4 3.1 2 1 0 3 3 3 0 fungal STAND N-terminal Goodbye domain Laminin_II PF06009.12 ETO33312.1 - 9.5 6.2 16.9 62 3.6 16.4 2.4 1 1 0 1 1 1 0 Laminin Domain II ABC_tran PF00005.27 ETO33313.1 - 3.3e-25 89.2 0.6 1.4e-24 87.2 0.0 2.3 2 1 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ETO33313.1 - 1e-06 28.4 0.8 2.7e-05 23.7 0.8 2.2 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain AAA_25 PF13481.6 ETO33313.1 - 4.1e-05 23.3 0.0 0.053 13.1 0.0 2.3 2 0 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ETO33313.1 - 8e-05 22.6 1.6 8.6e-05 22.5 0.1 1.8 2 1 0 2 2 2 1 RsgA GTPase AAA_22 PF13401.6 ETO33313.1 - 0.0013 19.0 3.1 0.049 13.9 3.1 2.6 1 1 0 1 1 1 1 AAA domain AAA_29 PF13555.6 ETO33313.1 - 0.0014 18.4 0.1 0.0033 17.1 0.1 1.6 1 0 0 1 1 1 1 P-loop containing region of AAA domain NTPase_1 PF03266.15 ETO33313.1 - 0.0027 17.6 0.8 1.7 8.6 0.1 2.5 2 1 0 2 2 2 2 NTPase AAA_7 PF12775.7 ETO33313.1 - 0.0049 16.4 0.1 0.0099 15.4 0.1 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO33313.1 - 0.0056 17.1 1.1 0.37 11.2 0.0 3.0 3 0 0 3 3 3 1 ATPase family associated with various cellular activities (AAA) SbcCD_C PF13558.6 ETO33313.1 - 0.0072 16.5 0.8 0.07 13.4 0.8 2.4 1 1 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_30 PF13604.6 ETO33313.1 - 0.011 15.4 3.8 0.19 11.4 3.8 2.3 1 1 0 1 1 1 0 AAA domain AAA_21 PF13304.6 ETO33313.1 - 0.012 15.4 0.1 0.03 14.1 0.0 1.7 2 0 0 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system AAA_16 PF13191.6 ETO33313.1 - 0.018 15.4 2.1 0.12 12.8 2.1 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_5 PF07728.14 ETO33313.1 - 0.021 14.8 0.0 0.27 11.2 0.0 2.7 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) IstB_IS21 PF01695.17 ETO33313.1 - 0.029 14.1 0.1 0.92 9.2 0.0 2.4 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_18 PF13238.6 ETO33313.1 - 0.048 14.2 0.8 0.29 11.7 0.0 2.6 3 0 0 3 3 3 0 AAA domain MMR_HSR1 PF01926.23 ETO33313.1 - 0.074 13.1 0.5 0.27 11.3 0.0 2.2 2 1 0 2 2 2 0 50S ribosome-binding GTPase AAA_33 PF13671.6 ETO33313.1 - 0.08 13.1 3.2 0.18 11.9 0.3 2.5 2 1 0 2 2 2 0 AAA domain LAGLIDADG_WhiA PF14527.6 ETO33313.1 - 0.088 12.9 0.1 0.21 11.7 0.1 1.7 1 0 0 1 1 1 0 WhiA LAGLIDADG-like domain AAA_24 PF13479.6 ETO33313.1 - 0.092 12.5 1.4 0.19 11.5 0.1 2.1 2 1 1 3 3 3 0 AAA domain NACHT PF05729.12 ETO33313.1 - 0.23 11.3 1.8 0.44 10.5 0.3 2.0 2 0 0 2 2 2 0 NACHT domain AAA_23 PF13476.6 ETO33313.1 - 6.3 7.2 10.6 92 3.4 10.2 2.5 1 1 0 1 1 1 0 AAA domain WD40 PF00400.32 ETO33314.1 - 1.7e-23 82.5 19.8 6.6e-06 26.8 0.3 4.8 4 1 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO33314.1 - 6.3e-07 28.4 1.2 0.35 9.5 0.0 3.5 2 2 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33314.1 - 7.1e-06 26.2 0.1 0.081 13.2 0.0 3.6 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Raftlin PF15250.6 ETO33315.1 - 0.09 11.5 9.7 0.092 11.5 9.7 1.0 1 0 0 1 1 1 0 Raftlin EPL1 PF10513.9 ETO33315.1 - 0.45 10.9 11.5 0.54 10.6 11.5 1.1 1 0 0 1 1 1 0 Enhancer of polycomb-like Dsh_C PF12316.8 ETO33315.1 - 1.4 9.2 9.4 1.6 9.1 9.4 1.0 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CCSAP PF15748.5 ETO33315.1 - 2.1 8.5 17.7 2.3 8.3 17.7 1.0 1 0 0 1 1 1 0 Centriole, cilia and spindle-associated Tim54 PF11711.8 ETO33315.1 - 3.7 6.2 16.2 4.2 6.1 16.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Presenilin PF01080.17 ETO33315.1 - 3.9 6.2 12.9 4 6.1 12.9 1.1 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO33315.1 - 4.6 6.2 10.3 4.6 6.2 10.3 1.0 1 0 0 1 1 1 0 Solute carrier family 12 RR_TM4-6 PF06459.12 ETO33315.1 - 4.9 6.9 17.4 5.2 6.8 17.4 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TMPIT PF07851.13 ETO33315.1 - 7 5.8 5.9 8 5.6 5.9 1.0 1 0 0 1 1 1 0 TMPIT-like protein ALMT PF11744.8 ETO33315.1 - 8.8 5.0 8.2 10 4.8 8.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Pkinase PF00069.25 ETO33317.1 - 5.5e-60 203.0 0.0 7.9e-60 202.4 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33317.1 - 5.6e-22 78.3 0.0 2e-21 76.5 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO33317.1 - 8.5e-05 22.0 0.0 1.3 8.2 0.0 3.1 2 1 0 3 3 3 2 Kinase-like WD40 PF00400.32 ETO33318.1 - 2e-40 136.0 22.5 1.9e-06 28.5 0.8 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33318.1 - 3.1e-13 49.8 2.1 0.0068 16.7 0.0 5.8 4 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33318.1 - 1.9e-12 46.6 6.4 0.0091 14.7 0.0 5.6 2 2 4 6 6 6 6 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO33318.1 - 0.00066 18.5 8.1 0.0035 16.1 3.6 3.6 1 1 1 2 2 2 1 Nup133 N terminal like DUF851 PF05867.11 ETO33318.1 - 0.15 11.6 0.0 10 5.5 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF851) WD40 PF00400.32 ETO33319.1 - 2.2e-12 47.3 13.9 0.00076 20.2 0.4 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat PADR1 PF08063.12 ETO33319.1 - 0.033 14.0 1.8 2.2 8.1 0.1 2.5 2 0 0 2 2 2 0 PADR1 (NUC008) domain TPR_7 PF13176.6 ETO33322.1 - 3.2e-23 80.0 1.1 7.4e-08 31.9 0.1 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_12 PF13424.6 ETO33322.1 - 3.7e-23 81.6 1.2 3.1e-16 59.4 0.1 2.5 3 0 0 3 3 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33322.1 - 3.5e-21 73.6 18.7 9.6e-08 31.7 1.2 3.5 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33322.1 - 4.7e-21 73.7 22.6 2.2e-08 33.5 3.1 3.6 4 0 0 4 4 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33322.1 - 8.2e-21 73.2 1.5 8.9e-07 28.6 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33322.1 - 5.2e-17 60.5 12.8 8.7e-06 25.5 0.6 3.4 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33322.1 - 2.6e-06 27.7 1.8 0.027 15.1 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33322.1 - 8.8e-06 26.3 0.0 0.03 15.0 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33322.1 - 3.5e-05 24.3 0.1 0.78 10.7 0.0 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33322.1 - 0.00011 22.3 11.0 0.23 11.9 0.3 5.0 5 1 0 5 5 5 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO33322.1 - 0.00025 20.9 4.0 0.004 16.9 0.2 2.4 1 1 1 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) SNAP PF14938.6 ETO33322.1 - 0.00025 20.6 2.8 0.00075 19.0 2.8 1.7 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP ATP-synt_E_2 PF08112.11 ETO33322.1 - 0.011 15.9 9.4 0.43 10.9 1.2 3.8 3 0 0 3 3 3 0 ATP synthase epsilon subunit ANAPC3 PF12895.7 ETO33322.1 - 0.015 15.5 3.0 1.5 9.1 0.1 2.6 2 0 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO33322.1 - 0.018 14.8 4.5 3.8 7.3 0.5 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO33322.1 - 0.024 14.6 7.7 0.089 12.8 0.6 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat OEP PF02321.18 ETO33322.1 - 0.033 14.0 0.1 4.9 6.9 0.2 2.4 2 0 0 2 2 2 0 Outer membrane efflux protein SHNi-TPR PF10516.9 ETO33322.1 - 0.089 12.3 1.5 0.57 9.7 0.1 2.6 3 0 0 3 3 3 0 SHNi-TPR TPR_11 PF13414.6 ETO33322.1 - 0.094 12.4 18.2 2 8.2 0.9 4.9 3 2 2 5 5 5 0 TPR repeat MIT PF04212.18 ETO33322.1 - 0.11 12.5 12.7 4.1 7.6 1.2 3.4 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain Sel1 PF08238.12 ETO33322.1 - 0.27 12.0 11.6 3 8.7 0.2 4.1 3 2 0 3 3 3 0 Sel1 repeat DUF4810 PF16068.5 ETO33322.1 - 2.3 8.8 6.2 4.4 7.9 1.3 3.1 2 1 1 3 3 3 0 Domain of unknown function (DUF4810) WD40 PF00400.32 ETO33323.1 - 1.1e-26 92.5 14.4 1.7e-05 25.5 0.0 6.4 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33323.1 - 2.8e-08 33.9 0.9 3.7 7.9 0.0 5.0 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33323.1 - 7.9e-05 21.5 5.8 0.64 8.6 0.3 4.4 2 2 2 5 5 5 4 Nucleoporin Nup120/160 VPS13 PF16908.5 ETO33325.1 - 1.8e-07 31.2 1.0 5e-07 29.8 1.0 1.8 1 1 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal MFS_4 PF06779.14 ETO33325.1 - 0.13 11.5 0.1 0.18 11.1 0.1 1.1 1 0 0 1 1 1 0 Uncharacterised MFS-type transporter YbfB SOBP PF15279.6 ETO33325.1 - 3.3 8.2 11.5 4.7 7.7 11.5 1.1 1 0 0 1 1 1 0 Sine oculis-binding protein DUF515 PF04415.12 ETO33325.1 - 4.7 5.5 11.1 7.7 4.8 11.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF515) THOC7 PF05615.13 ETO33326.1 - 2e-08 34.6 11.4 2e-08 34.6 11.4 1.9 1 1 1 2 2 2 1 Tho complex subunit 7 zf-C4H2 PF10146.9 ETO33326.1 - 0.02 15.2 14.3 0.03 14.6 14.3 1.3 1 0 0 1 1 1 0 Zinc finger-containing protein DUF1664 PF07889.12 ETO33326.1 - 6.9 6.7 9.5 1.1 9.3 1.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) LRR_4 PF12799.7 ETO33328.1 - 0.0029 18.0 13.0 0.21 12.1 0.2 4.5 3 2 3 6 6 6 5 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO33328.1 - 0.04 13.7 8.4 0.47 10.3 0.2 3.5 2 1 1 3 3 3 0 Leucine rich repeat SMN PF06003.12 ETO33328.1 - 2.7 7.2 6.7 5.4 6.2 0.0 2.2 2 0 0 2 2 2 0 Survival motor neuron protein (SMN) ubiquitin PF00240.23 ETO33329.1 - 3.5e-32 110.0 5.1 3.4e-15 55.5 0.2 4.1 4 0 0 4 4 4 4 Ubiquitin family Rad60-SLD PF11976.8 ETO33329.1 - 1.1e-10 41.2 2.3 6e-06 26.0 0.1 3.0 4 0 0 4 4 4 2 Ubiquitin-2 like Rad60 SUMO-like Rad10 PF03834.14 ETO33329.1 - 0.028 14.4 0.7 0.067 13.2 0.5 1.7 1 1 0 1 1 1 0 Binding domain of DNA repair protein Ercc1 (rad10/Swi10) Ubiquitin_5 PF18037.1 ETO33329.1 - 0.066 13.6 0.7 0.34 11.3 0.1 2.3 1 1 1 2 2 2 0 Ubiquitin-like domain DUF2407 PF10302.9 ETO33329.1 - 0.067 13.7 0.4 0.17 12.5 0.1 2.0 2 1 0 2 2 2 0 DUF2407 ubiquitin-like domain PDGLE PF13190.6 ETO33329.1 - 0.5 10.3 2.3 7.1 6.6 0.1 3.0 2 1 1 3 3 3 0 PDGLE domain TPR_12 PF13424.6 ETO33330.1 - 7.8e-65 215.1 1.6 1.5e-19 70.0 0.0 4.6 4 1 1 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33330.1 - 9e-45 148.7 34.5 4.6e-08 32.6 0.3 7.9 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33330.1 - 3.3e-41 138.0 0.0 2.7e-09 36.6 0.0 7.3 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33330.1 - 5e-41 135.5 32.7 1.2e-08 34.5 0.2 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33330.1 - 2.4e-40 133.6 1.6 3.1e-06 26.8 0.0 7.3 7 0 0 7 7 7 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33330.1 - 4.6e-33 110.6 19.9 2.3e-05 24.1 0.1 8.0 8 0 0 8 8 8 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33330.1 - 1.6e-11 43.7 30.7 0.0036 16.9 0.3 8.3 7 3 2 9 9 9 5 TPR repeat TPR_17 PF13431.6 ETO33330.1 - 4.3e-11 42.4 12.7 0.17 12.3 0.0 7.9 9 1 1 10 10 8 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33330.1 - 5.7e-10 39.2 2.6 2.3 9.0 0.0 7.1 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33330.1 - 8.3e-10 38.7 0.0 9.3 7.4 0.0 6.9 8 0 0 8 8 6 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO33330.1 - 9.3e-08 32.0 13.2 0.29 11.0 0.1 6.1 4 2 2 6 6 6 1 Domain of unknown function (DUF5113) MIT PF04212.18 ETO33330.1 - 9.8e-08 32.0 16.8 0.53 10.4 0.2 6.4 4 1 2 6 6 6 3 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO33330.1 - 3.1e-07 30.3 9.5 0.016 14.9 0.3 4.8 1 1 4 5 5 5 3 Uncharacterized protein conserved in bacteria (DUF2225) Sel1 PF08238.12 ETO33330.1 - 1.5e-06 28.7 4.2 0.65 10.8 0.0 5.7 6 0 0 6 6 5 1 Sel1 repeat TPR_3 PF07720.12 ETO33330.1 - 1.7e-06 27.9 15.4 0.01 15.8 0.1 6.7 7 0 0 7 7 7 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO33330.1 - 8.5e-06 25.4 0.0 0.017 14.5 0.0 2.4 1 1 1 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 ETO33330.1 - 1.7e-05 25.3 0.0 13 6.6 0.0 5.4 5 2 0 5 5 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO33330.1 - 8e-05 22.0 1.7 6.4 6.3 0.1 5.2 5 0 0 5 5 5 1 SHNi-TPR RPN7 PF10602.9 ETO33330.1 - 0.00071 19.3 9.3 1.7 8.3 0.1 4.1 1 1 3 4 4 4 2 26S proteasome subunit RPN7 mit_SMPDase PF14724.6 ETO33330.1 - 0.0017 16.4 0.2 0.17 9.9 0.1 2.1 1 1 1 2 2 2 2 Mitochondrial-associated sphingomyelin phosphodiesterase DUF3856 PF12968.7 ETO33330.1 - 0.0044 17.1 1.4 3.4 7.7 0.1 3.8 2 2 1 4 4 4 1 Domain of Unknown Function (DUF3856) DUF627 PF04781.12 ETO33330.1 - 0.012 15.6 6.0 0.26 11.3 0.1 3.8 4 1 0 4 4 3 0 Protein of unknown function (DUF627) SPO22 PF08631.10 ETO33330.1 - 0.041 13.4 3.4 19 4.7 0.1 3.4 2 1 1 3 3 3 0 Meiosis protein SPO22/ZIP4 like NRBF2_MIT PF17169.4 ETO33330.1 - 0.059 13.6 2.0 5.6 7.3 0.0 4.2 5 0 0 5 5 4 0 MIT domain of nuclear receptor-binding factor 2 NSF PF02071.20 ETO33330.1 - 0.27 12.1 13.0 1.5e+02 3.9 0.1 6.8 6 0 0 6 6 6 0 Aromatic-di-Alanine (AdAR) repeat PPR PF01535.20 ETO33330.1 - 1.1 9.7 9.3 59 4.2 0.1 5.7 6 0 0 6 6 6 0 PPR repeat DUF1460 PF07313.12 ETO33331.1 - 0.013 14.9 7.9 0.53 9.6 0.6 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF1460) WD40 PF00400.32 ETO33332.1 - 9e-67 219.4 22.0 7.4e-11 42.4 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33332.1 - 2.3e-26 91.9 2.4 0.0021 18.3 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33332.1 - 1.9e-16 59.9 1.3 0.01 14.8 0.0 6.3 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33332.1 - 3.1e-11 43.2 1.2 0.00013 21.4 0.0 4.9 1 1 4 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO33332.1 - 6.3e-08 31.7 4.6 0.089 11.4 0.0 5.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO33332.1 - 8.4e-08 32.3 6.2 1.9 8.6 0.0 5.9 2 2 4 6 6 6 2 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO33332.1 - 2.4e-06 26.3 4.5 0.068 11.7 0.0 3.3 1 1 3 4 4 4 4 Cytochrome D1 heme domain PD40 PF07676.12 ETO33332.1 - 1.1e-05 25.2 7.7 9.9 6.2 0.1 6.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO33332.1 - 0.00036 19.4 9.2 0.58 8.8 0.0 4.1 1 1 2 4 4 4 3 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO33332.1 - 0.00075 18.7 1.3 0.23 10.5 0.0 2.2 1 1 1 2 2 2 2 Coatomer WD associated region PALB2_WD40 PF16756.5 ETO33332.1 - 0.0011 18.0 1.0 0.11 11.4 0.1 3.5 2 1 2 4 4 4 1 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO33332.1 - 0.0021 17.5 1.6 2.4 7.4 0.1 3.5 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Utp8 PF10395.9 ETO33332.1 - 0.0026 16.4 0.1 0.99 7.8 0.0 2.3 1 1 0 2 2 2 2 Utp8 family OapA PF04225.12 ETO33332.1 - 0.0062 16.6 0.1 3.8 7.7 0.0 3.1 2 1 1 3 3 3 1 Opacity-associated protein A LysM-like domain ArlS_N PF18719.1 ETO33332.1 - 0.016 15.4 0.2 26 5.0 0.0 4.0 1 1 3 5 5 5 0 ArlS sensor domain DPPIV_N PF00930.21 ETO33332.1 - 0.026 13.3 0.0 9.7 4.8 0.0 3.4 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Big_7 PF17957.1 ETO33332.1 - 0.029 15.1 1.4 1.6 9.6 0.0 3.6 3 1 1 4 4 4 0 Bacterial Ig domain Alpha-amyl_C PF09071.10 ETO33332.1 - 0.1 12.5 0.6 0.49 10.3 0.5 2.1 2 0 0 2 2 2 0 Alpha-amylase, C terminal SBD PF17882.1 ETO33332.1 - 0.13 12.0 0.8 30 4.4 0.0 3.9 1 1 1 3 3 3 0 OAA-family lectin sugar binding domain Proteasome_A_N PF10584.9 ETO33332.1 - 0.65 9.7 8.1 42 3.9 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature FlaC_arch PF05377.11 ETO33333.1 - 0.01 16.2 8.4 0.018 15.4 7.5 1.8 1 1 1 2 2 2 0 Flagella accessory protein C (FlaC) Lipoprotein_20 PF13942.6 ETO33333.1 - 0.47 10.3 7.7 0.57 10.1 7.7 1.1 1 0 0 1 1 1 0 YfhG lipoprotein TPR_2 PF07719.17 ETO33334.1 - 0.0088 16.1 0.6 0.62 10.3 0.0 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat ELFV_dehydrog PF00208.21 ETO33335.1 - 6.5e-80 268.4 1.2 7.6e-80 268.1 1.2 1.0 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ETO33335.1 - 2.7e-22 79.0 0.0 7.4e-22 77.6 0.0 1.8 2 0 0 2 2 2 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain O-antigen_lig PF13425.6 ETO33336.1 - 0.1 11.4 6.4 0.14 10.9 6.4 1.3 1 1 0 1 1 1 0 O-antigen ligase like membrane protein DUF4598 PF15370.6 ETO33336.1 - 0.1 13.1 0.2 0.1 13.1 0.2 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4598) DUF2615 PF11027.8 ETO33336.1 - 0.53 10.4 2.8 0.59 10.3 0.1 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF2615) Podoplanin PF05808.11 ETO33336.1 - 0.77 9.9 3.8 1.2 9.2 3.8 1.3 1 0 0 1 1 1 0 Podoplanin DUF4834 PF16118.5 ETO33337.1 - 0.0023 18.8 4.2 0.14 13.1 0.3 2.5 2 0 0 2 2 2 2 Domain of unknown function (DUF4834) DUF1289 PF06945.13 ETO33338.1 - 0.11 12.3 0.2 0.37 10.6 0.2 1.9 1 0 0 1 1 1 0 Protein of unknown function (DUF1289) DUF1284 PF06935.11 ETO33338.1 - 6 7.4 5.7 3.6 8.1 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1284) Peptidase_C101 PF16218.5 ETO33339.1 - 0.012 14.9 1.4 0.018 14.3 1.4 1.3 1 0 0 1 1 1 0 Peptidase family C101 YtxH PF12732.7 ETO33341.1 - 0.034 14.7 0.4 0.13 12.8 0.2 2.1 2 1 0 2 2 2 0 YtxH-like protein DUF1690 PF07956.11 ETO33341.1 - 0.043 14.2 9.0 0.082 13.3 9.0 1.6 1 1 0 1 1 1 0 Protein of Unknown function (DUF1690) Endotoxin_N PF03945.14 ETO33341.1 - 0.12 12.1 4.3 3.8 7.2 4.3 2.3 1 1 0 1 1 1 0 delta endotoxin, N-terminal domain Nnf1 PF03980.14 ETO33341.1 - 0.26 11.7 8.4 0.84 10.0 0.3 3.1 3 0 0 3 3 3 0 Nnf1 Fib_alpha PF08702.10 ETO33341.1 - 3.5 7.8 12.3 7 6.8 8.2 2.5 1 1 1 2 2 2 0 Fibrinogen alpha/beta chain family UCH PF00443.29 ETO33342.1 - 1.7e-09 37.6 1.4 1.7e-09 37.6 1.4 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase ESM4 PF15952.5 ETO33342.1 - 0.041 14.3 1.0 0.068 13.6 1.0 1.4 1 0 0 1 1 1 0 Enhancer of split M4 family DUF2582 PF10771.9 ETO33342.1 - 0.078 13.1 0.5 0.17 12.1 0.1 2.0 2 1 0 2 2 2 0 Winged helix-turn-helix domain (DUF2582) Takusan PF04822.13 ETO33342.1 - 0.12 12.3 2.4 5.1 7.1 0.7 2.3 2 0 0 2 2 2 0 Takusan BORCS7 PF16088.5 ETO33343.1 - 0.18 12.1 4.6 0.13 12.5 1.5 2.3 2 1 0 2 2 2 0 BLOC-1-related complex sub-unit 7 DUF2228 PF10228.9 ETO33343.1 - 0.72 9.5 8.2 3.8 7.2 3.8 2.3 2 0 0 2 2 2 0 Uncharacterised conserved protein (DUF2228) Plant_NMP1 PF06694.11 ETO33344.1 - 0.024 13.8 1.4 0.024 13.8 1.4 1.0 1 0 0 1 1 1 0 Plant nuclear matrix protein 1 (NMP1) Ribonuc_P_40 PF08584.11 ETO33346.1 - 0.0053 16.1 0.6 0.0062 15.8 0.6 1.1 1 0 0 1 1 1 1 Ribonuclease P 40kDa (Rpp40) subunit Esterase PF00756.20 ETO33348.1 - 1.7e-18 67.2 0.0 2.2e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Putative esterase DUF4176 PF13780.6 ETO33348.1 - 0.08 13.0 0.3 0.15 12.1 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4176) ADH_N PF08240.12 ETO33350.1 - 1e-20 73.6 0.5 3.1e-19 68.9 0.5 2.4 1 1 0 1 1 1 1 Alcohol dehydrogenase GroES-like domain ADH_zinc_N PF00107.26 ETO33350.1 - 0.0015 18.5 0.0 0.0033 17.4 0.0 1.6 1 0 0 1 1 1 1 Zinc-binding dehydrogenase EFP PF01132.20 ETO33350.1 - 0.018 15.1 0.0 0.034 14.2 0.0 1.4 1 0 0 1 1 1 0 Elongation factor P (EF-P) OB domain ADH_N_2 PF16884.5 ETO33350.1 - 0.072 13.0 0.0 0.14 12.1 0.0 1.5 1 1 0 1 1 1 0 N-terminal domain of oxidoreductase 2-Hacid_dh_C PF02826.19 ETO33350.1 - 0.23 10.8 0.5 0.39 10.1 0.5 1.3 1 0 0 1 1 1 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain CLLAC PF15675.5 ETO33350.1 - 4.6 6.9 6.2 3.6 7.2 3.3 2.0 2 0 0 2 2 2 0 CLLAC-motif containing domain ADH_zinc_N PF00107.26 ETO33351.1 - 3.5e-13 49.7 0.0 4.4e-13 49.3 0.0 1.1 1 0 0 1 1 1 1 Zinc-binding dehydrogenase ADH_zinc_N_2 PF13602.6 ETO33351.1 - 0.00034 21.7 0.0 0.00046 21.2 0.0 1.2 1 0 0 1 1 1 1 Zinc-binding dehydrogenase TruD PF01142.18 ETO33352.1 - 7.4e-44 150.2 3.4 9.3e-43 146.6 2.3 2.3 2 0 0 2 2 2 2 tRNA pseudouridine synthase D (TruD) CENP-B_dimeris PF09026.10 ETO33352.1 - 3.1 8.2 30.0 0.32 11.4 0.1 4.7 4 1 0 4 4 4 0 Centromere protein B dimerisation domain EcKinase PF02958.20 ETO33353.1 - 3.1e-07 30.0 2.0 6.5e-06 25.7 2.0 2.5 1 1 0 1 1 1 1 Ecdysteroid kinase DUF1679 PF07914.11 ETO33353.1 - 1.1e-06 27.8 1.6 5.7e-06 25.5 1.5 1.9 1 1 0 1 1 1 1 Protein of unknown function (DUF1679) APH PF01636.23 ETO33353.1 - 0.0015 18.5 0.0 0.02 14.8 0.0 2.2 1 1 0 1 1 1 1 Phosphotransferase enzyme family Sirohm_synth_C PF14823.6 ETO33353.1 - 0.066 12.9 2.2 0.096 12.3 1.0 1.9 2 0 0 2 2 2 0 Sirohaem biosynthesis protein C-terminal WD40 PF00400.32 ETO33355.1 - 5.8e-59 194.7 28.4 1.1e-07 32.4 0.8 8.9 9 0 0 9 9 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33355.1 - 5.4e-23 81.1 3.6 0.00039 20.7 0.0 7.5 2 1 6 8 8 8 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33355.1 - 1.8e-14 53.8 6.5 0.00039 19.8 0.0 5.2 4 1 2 6 6 6 4 WD40-like domain Ge1_WD40 PF16529.5 ETO33355.1 - 1.9e-12 46.8 0.9 0.14 11.1 0.3 5.8 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33355.1 - 1.1e-08 34.2 4.7 0.37 9.4 0.1 6.1 1 1 5 6 6 6 3 Nucleoporin Nup120/160 Kelch_6 PF13964.6 ETO33355.1 - 7.4e-07 29.2 0.2 0.36 11.2 0.1 5.1 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO33355.1 - 1.3e-06 28.1 0.4 0.035 14.1 0.0 4.9 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO33355.1 - 2e-06 27.3 1.3 0.00072 19.1 0.2 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO33355.1 - 6.5e-06 26.1 2.1 0.00033 20.6 0.0 3.6 2 1 1 3 3 3 1 Galactose oxidase, central domain Cytochrom_D1 PF02239.16 ETO33355.1 - 7.5e-05 21.4 0.3 0.0069 15.0 0.1 3.1 1 1 4 5 5 5 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO33355.1 - 0.00029 20.7 2.4 2.1 8.4 0.0 4.0 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat Kelch_3 PF13415.6 ETO33355.1 - 0.0049 17.1 0.0 0.072 13.4 0.0 3.0 2 0 0 2 2 2 1 Galactose oxidase, central domain PQQ PF01011.21 ETO33355.1 - 0.026 14.4 0.0 45 4.2 0.0 4.1 4 0 0 4 4 4 0 PQQ enzyme repeat DUF5570 PF17731.1 ETO33355.1 - 0.031 14.4 1.4 17 5.5 0.0 4.5 2 1 3 5 5 5 0 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO33355.1 - 0.039 13.3 1.0 3.7 6.8 0.0 3.2 1 1 0 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF5046 PF16465.5 ETO33355.1 - 0.051 13.0 0.0 0.72 9.3 0.0 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF5046) Kelch_5 PF13854.6 ETO33355.1 - 0.1 12.6 0.9 1.6 8.8 0.0 3.4 4 0 0 4 4 3 0 Kelch motif Proteasome_A_N PF10584.9 ETO33355.1 - 6.3 6.6 6.5 13 5.6 0.0 3.2 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO33356.1 - 1.3e-11 44.8 7.9 1.6e-06 28.7 2.3 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO33356.1 - 0.00078 18.3 0.6 0.0014 17.4 0.5 1.5 1 1 0 1 1 1 1 Nup133 N terminal like WD40_like PF17005.5 ETO33356.1 - 0.0027 17.1 0.3 0.021 14.1 0.3 1.9 1 1 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO33356.1 - 0.008 14.9 1.0 1.2 7.7 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Pkinase PF00069.25 ETO33357.1 - 2.1e-46 158.5 0.3 1.3e-39 136.1 0.0 2.5 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33357.1 - 1.4e-21 77.0 0.1 6.1e-21 74.9 0.0 2.0 2 1 0 2 2 2 1 Protein tyrosine kinase Kdo PF06293.14 ETO33357.1 - 0.0006 19.2 1.6 0.00082 18.8 0.1 1.9 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family KA1 PF02149.19 ETO33357.1 - 0.00078 19.2 0.1 0.0029 17.4 0.1 2.0 1 1 0 1 1 1 1 Kinase associated domain 1 Kinase-like PF14531.6 ETO33357.1 - 0.0011 18.3 0.0 0.0037 16.6 0.0 1.8 2 0 0 2 2 2 1 Kinase-like ABC_membrane PF00664.23 ETO33358.1 - 4.3e-20 72.5 4.6 4.3e-20 72.5 4.6 3.0 3 0 0 3 3 3 2 ABC transporter transmembrane region DUF445 PF04286.12 ETO33358.1 - 0.02 14.7 1.5 0.04 13.7 0.0 2.1 2 1 1 3 3 3 0 Protein of unknown function (DUF445) CSN7a_helixI PF18392.1 ETO33358.1 - 0.41 10.6 3.9 7.3 6.6 0.6 2.6 2 0 0 2 2 2 0 COP9 signalosome complex subunit 7a helix I domain Ank_2 PF12796.7 ETO33359.1 - 8.4e-44 148.1 7.1 7.3e-14 52.1 0.0 5.4 2 2 2 5 5 5 5 Ankyrin repeats (3 copies) Ank PF00023.30 ETO33359.1 - 3.4e-35 119.0 6.4 8e-05 22.9 0.1 8.6 9 0 0 9 9 9 7 Ankyrin repeat Ank_3 PF13606.6 ETO33359.1 - 3.1e-32 107.0 8.3 4.9e-05 23.4 0.0 9.1 9 0 0 9 9 9 7 Ankyrin repeat Ank_4 PF13637.6 ETO33359.1 - 7.4e-30 102.9 3.7 3.1e-06 27.6 0.1 8.0 4 1 4 8 8 8 7 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO33359.1 - 3.7e-28 97.2 1.2 8.5e-06 26.0 0.0 6.6 4 2 3 7 7 7 7 Ankyrin repeats (many copies) AAA_lid_1 PF17857.1 ETO33359.1 - 0.091 13.0 0.2 2.2 8.5 0.0 2.4 2 0 0 2 2 2 0 AAA+ lid domain PI3_PI4_kinase PF00454.27 ETO33361.1 - 8.5e-26 91.3 2.2 1.7e-21 77.2 0.5 3.2 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase ABM PF03992.16 ETO33362.1 - 9.7e-18 64.1 0.3 1.8e-17 63.2 0.0 1.6 2 0 0 2 2 2 1 Antibiotic biosynthesis monooxygenase DUF4286 PF14114.6 ETO33362.1 - 0.085 13.4 0.3 0.085 13.4 0.3 2.5 2 1 0 2 2 2 0 Domain of unknown function (DUF4286) zf_Hakai PF18408.1 ETO33362.1 - 0.92 9.3 5.4 4.9 7.0 0.1 3.3 3 0 0 3 3 3 0 C2H2 Hakai zinc finger domain F-box PF00646.33 ETO33363.1 - 0.0073 16.2 0.0 0.016 15.1 0.0 1.6 1 0 0 1 1 1 1 F-box domain F-box-like PF12937.7 ETO33363.1 - 0.0089 15.9 0.0 0.021 14.7 0.0 1.6 1 0 0 1 1 1 1 F-box-like Peptidase_S49_N PF08496.10 ETO33364.1 - 0.092 12.8 6.1 0.1 12.6 6.1 1.2 1 0 0 1 1 1 0 Peptidase family S49 N-terminal WD40 PF00400.32 ETO33365.1 - 1.8e-44 148.8 35.1 3.5e-06 27.6 0.2 8.3 8 0 0 8 8 8 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33365.1 - 8.3e-14 51.7 1.9 0.0024 18.1 0.0 6.0 5 2 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33365.1 - 3.4e-07 29.3 6.6 0.0046 15.7 0.2 4.8 2 1 3 5 5 5 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO33365.1 - 5.1e-05 23.9 2.7 5.1e-05 23.9 2.7 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger WD40_like PF17005.5 ETO33365.1 - 0.00013 21.4 0.4 0.043 13.1 0.1 3.2 2 1 0 3 3 3 2 WD40-like domain Fzo_mitofusin PF04799.13 ETO33365.1 - 0.037 13.6 2.9 0.069 12.7 2.9 1.3 1 0 0 1 1 1 0 fzo-like conserved region zf-TRAF_2 PF15965.5 ETO33365.1 - 0.074 13.5 2.3 0.31 11.5 2.3 2.1 1 0 0 1 1 1 0 TRAF-like zinc-finger MCM PF00493.23 ETO33366.1 - 1.2e-95 318.9 0.1 2.3e-95 317.9 0.1 1.4 1 0 0 1 1 1 1 MCM P-loop domain MCM_OB PF17207.3 ETO33366.1 - 9e-36 122.5 0.1 1.6e-35 121.7 0.1 1.4 1 0 0 1 1 1 1 MCM OB domain MCM_lid PF17855.1 ETO33366.1 - 3.4e-26 91.5 1.8 8.1e-26 90.3 1.8 1.7 1 0 0 1 1 1 1 MCM AAA-lid domain MCM_N PF14551.6 ETO33366.1 - 1.4e-16 61.0 0.7 9.1e-15 55.1 0.1 2.5 2 0 0 2 2 2 1 MCM N-terminal domain Mg_chelatase PF01078.21 ETO33366.1 - 2.5e-06 27.0 0.0 1.5e-05 24.5 0.0 2.2 2 0 0 2 2 2 1 Magnesium chelatase, subunit ChlI AAA_3 PF07726.11 ETO33366.1 - 0.0037 17.1 0.0 0.009 15.9 0.0 1.7 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Mg_chelatase_C PF13335.6 ETO33366.1 - 0.02 15.5 0.3 0.02 15.5 0.3 2.8 4 0 0 4 4 4 0 Magnesium chelatase, subunit ChlI C-terminal AAA_5 PF07728.14 ETO33366.1 - 0.031 14.3 0.0 0.076 13.0 0.0 1.7 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) AAA_lid_5 PF17865.1 ETO33366.1 - 0.16 12.1 0.2 1.4 9.0 0.1 2.3 1 1 1 2 2 2 0 Midasin AAA lid domain ABC_tran PF00005.27 ETO33367.1 - 9.4e-15 55.3 1.4 9e-14 52.2 0.0 2.1 2 0 0 2 2 2 1 ABC transporter 60KD_IMP PF02096.20 ETO33368.1 - 0.029 14.3 0.0 0.058 13.3 0.0 1.5 1 0 0 1 1 1 0 60Kd inner membrane protein MscS_TM PF12794.7 ETO33368.1 - 0.092 11.6 0.0 0.13 11.1 0.0 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Dynein_C PF18199.1 ETO33369.1 - 4.4e-07 29.4 0.5 5.6e-07 29.1 0.5 1.2 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain DUF2201_N PF13203.6 ETO33369.1 - 0.059 13.0 0.0 0.07 12.7 0.0 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain TauD PF02668.16 ETO33370.1 - 2.4e-35 122.7 0.0 3e-35 122.3 0.0 1.1 1 0 0 1 1 1 1 Taurine catabolism dioxygenase TauD, TfdA family KCT2 PF17818.1 ETO33371.1 - 0.0022 18.2 3.8 0.0044 17.2 3.8 1.4 1 1 0 1 1 1 1 Keratinocyte-associated gene product SOG2 PF10428.9 ETO33371.1 - 0.0074 15.6 1.4 0.0091 15.2 1.4 1.0 1 0 0 1 1 1 1 RAM signalling pathway protein Dak2 PF02734.17 ETO33371.1 - 0.13 12.2 0.4 0.16 11.8 0.4 1.2 1 0 0 1 1 1 0 DAK2 domain Utp21 PF04192.12 ETO33371.1 - 0.14 11.6 8.7 0.064 12.8 6.1 1.5 1 1 1 2 2 2 0 Utp21 specific WD40 associated putative domain SlyX PF04102.12 ETO33371.1 - 0.32 11.6 6.6 1.2 9.8 6.8 1.8 1 1 1 2 2 2 0 SlyX DUF4407 PF14362.6 ETO33371.1 - 0.48 9.7 5.9 0.54 9.6 5.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF3552 PF12072.8 ETO33371.1 - 0.7 9.3 14.9 0.87 9.0 14.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3552) DUF5531 PF17671.1 ETO33371.1 - 0.86 9.5 8.1 1.4 8.8 8.1 1.4 1 1 0 1 1 1 0 Family of unknown function (DUF5531) OmpH PF03938.14 ETO33371.1 - 1.7 9.0 13.0 1 9.7 11.7 1.3 1 1 0 1 1 1 0 Outer membrane protein (OmpH-like) Vfa1 PF08432.10 ETO33371.1 - 1.8 8.9 15.1 2.2 8.6 15.1 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SpoIIIAH PF12685.7 ETO33371.1 - 2.4 8.0 15.0 3.1 7.6 15.0 1.1 1 0 0 1 1 1 0 SpoIIIAH-like protein LAMTOR PF15454.6 ETO33371.1 - 2.8 8.6 9.5 0.29 11.8 1.1 2.4 1 1 1 2 2 2 0 Late endosomal/lysosomal adaptor and MAPK and MTOR activator CLN3 PF02487.17 ETO33371.1 - 3.8 6.4 4.4 4.5 6.2 4.4 1.1 1 0 0 1 1 1 0 CLN3 protein DUF1387 PF07139.11 ETO33371.1 - 4.3 7.0 16.0 5.8 6.5 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) HSP70 PF00012.20 ETO33371.1 - 5.7 5.0 12.1 6.5 4.8 12.1 1.0 1 0 0 1 1 1 0 Hsp70 protein Afi1 PF07792.12 ETO33371.1 - 8.4 6.9 13.7 32 5.0 13.7 1.8 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking FSH1 PF03959.13 ETO33372.1 - 2.8e-44 151.3 0.0 3.2e-44 151.1 0.0 1.0 1 0 0 1 1 1 1 Serine hydrolase (FSH1) Hydrolase_4 PF12146.8 ETO33372.1 - 0.047 12.9 0.0 6.3 6.0 0.0 2.7 2 1 1 3 3 3 0 Serine aminopeptidase, S33 Palm_thioest PF02089.15 ETO33372.1 - 0.086 12.7 0.0 0.12 12.2 0.0 1.2 1 0 0 1 1 1 0 Palmitoyl protein thioesterase Abhydrolase_1 PF00561.20 ETO33372.1 - 0.11 12.1 0.1 2.4 7.7 0.0 2.2 1 1 0 2 2 2 0 alpha/beta hydrolase fold Pro_isomerase PF00160.21 ETO33375.1 - 2.4e-42 144.9 0.2 2.9e-42 144.6 0.2 1.0 1 0 0 1 1 1 1 Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD ABC_tran_CTD PF16326.5 ETO33376.1 - 0.00034 20.8 8.2 0.00034 20.8 8.2 2.5 1 1 1 2 2 2 1 ABC transporter C-terminal domain MRP-S27 PF10037.9 ETO33376.1 - 0.0034 16.3 11.1 0.0052 15.7 11.1 1.2 1 0 0 1 1 1 1 Mitochondrial 28S ribosomal protein S27 FapA PF03961.13 ETO33376.1 - 0.031 12.9 5.7 0.058 12.0 5.7 1.4 1 0 0 1 1 1 0 Flagellar Assembly Protein A Dna2 PF08696.11 ETO33376.1 - 0.088 12.6 8.5 0.14 11.9 8.5 1.4 1 0 0 1 1 1 0 DNA replication factor Dna2 AAA_23 PF13476.6 ETO33376.1 - 0.48 10.9 10.8 1.1 9.8 10.8 1.6 1 0 0 1 1 1 0 AAA domain DUF406 PF04175.12 ETO33376.1 - 0.64 10.5 5.1 2.1 8.9 5.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF406) LMBR1 PF04791.16 ETO33376.1 - 0.82 8.5 7.4 1.6 7.6 7.4 1.5 1 0 0 1 1 1 0 LMBR1-like membrane protein V_ATPase_I PF01496.19 ETO33376.1 - 1.8 6.4 13.7 3 5.7 13.7 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Asparaginase_2 PF01112.18 ETO33376.1 - 2.8 6.9 6.9 5.8 5.8 6.9 1.5 1 0 0 1 1 1 0 Asparaginase Exonuc_VII_L PF02601.15 ETO33376.1 - 2.9 7.4 18.5 0.18 11.3 13.3 1.6 2 0 0 2 2 2 0 Exonuclease VII, large subunit PhoQ_Sensor PF08918.10 ETO33376.1 - 3.1 7.6 7.8 14 5.5 0.0 2.8 2 0 0 2 2 2 0 PhoQ Sensor SOGA PF11365.8 ETO33376.1 - 6.1 8.0 15.2 5 8.3 10.1 2.6 1 1 1 2 2 2 0 Protein SOGA MAS20 PF02064.15 ETO33376.1 - 6.2 6.9 13.3 2.4 8.3 9.7 2.1 1 1 0 1 1 1 0 MAS20 protein import receptor HEAT PF02985.22 ETO33377.1 - 4.1e-05 23.5 0.6 0.14 12.5 0.0 4.5 5 0 0 5 5 5 2 HEAT repeat HEAT_2 PF13646.6 ETO33377.1 - 0.00072 19.9 0.0 3.1 8.3 0.0 3.1 3 0 0 3 3 3 2 HEAT repeats HEAT_EZ PF13513.6 ETO33377.1 - 0.0068 16.9 0.0 12 6.6 0.0 4.0 5 0 0 5 5 5 1 HEAT-like repeat NACHT PF05729.12 ETO33378.1 - 8.6e-08 32.3 0.0 2.3e-07 30.9 0.0 1.7 1 0 0 1 1 1 1 NACHT domain NLRC4_HD2 PF17776.1 ETO33378.1 - 0.014 15.9 0.1 0.051 14.1 0.0 2.1 2 0 0 2 2 2 0 NLRC4 helical domain HD2 FACT-Spt16_Nlob PF14826.6 ETO33378.1 - 0.075 12.8 0.1 0.35 10.7 0.0 2.0 2 0 0 2 2 2 0 FACT complex subunit SPT16 N-terminal lobe domain Sarcoglycan_2 PF05510.13 ETO33379.1 - 0.0068 15.2 0.4 0.0072 15.1 0.4 1.0 1 0 0 1 1 1 1 Sarcoglycan alpha/epsilon DUF2937 PF11157.8 ETO33379.1 - 0.014 15.2 0.2 0.016 14.9 0.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) RNB PF00773.19 ETO33380.1 - 8.3e-66 222.5 1.0 1.2e-65 222.0 1.0 1.2 1 0 0 1 1 1 1 RNB domain Ribosomal_S19 PF00203.21 ETO33381.1 - 2.9e-27 94.4 1.1 5.5e-27 93.5 1.1 1.5 1 0 0 1 1 1 1 Ribosomal protein S19 Exo84_C PF16528.5 ETO33382.1 - 7.2e-15 55.3 10.7 1.2e-11 44.8 0.4 4.3 4 1 0 4 4 4 2 Exocyst component 84 C-terminal Vps51 PF08700.11 ETO33382.1 - 3.3e-06 27.1 0.0 2e-05 24.6 0.0 2.4 1 0 0 1 1 1 1 Vps51/Vps67 COG2 PF06148.11 ETO33382.1 - 9.6e-05 22.5 0.5 0.0018 18.4 0.2 2.6 2 0 0 2 2 2 1 COG (conserved oligomeric Golgi) complex component, COG2 DUF3899 PF13038.6 ETO33382.1 - 1.1 9.8 6.6 6.7 7.3 0.3 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) MFS_1 PF07690.16 ETO33383.1 - 3.6e-17 62.3 25.4 3.6e-17 62.3 25.4 2.7 2 1 1 3 3 3 3 Major Facilitator Superfamily Kinocilin PF15033.6 ETO33383.1 - 0.55 9.9 2.0 0.92 9.2 0.1 2.1 2 0 0 2 2 2 0 Kinocilin protein 2OG-FeII_Oxy_3 PF13640.6 ETO33384.1 - 8.8e-08 32.9 0.0 1.7e-07 32.0 0.0 1.4 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Oxygenase-NA PF09859.9 ETO33384.1 - 0.0022 17.5 0.0 0.0036 16.8 0.0 1.4 1 1 0 1 1 1 1 Oxygenase, catalysing oxidative methylation of damaged DNA MBT PF02820.18 ETO33385.1 - 0.0071 16.7 0.5 0.017 15.5 0.1 1.8 2 0 0 2 2 2 1 mbt repeat Agenet PF05641.12 ETO33385.1 - 0.0076 16.7 0.3 0.016 15.7 0.3 1.5 1 0 0 1 1 1 1 Agenet domain Rpr2 PF04032.16 ETO33385.1 - 0.032 14.5 0.3 0.081 13.2 0.3 1.8 1 0 0 1 1 1 0 RNAse P Rpr2/Rpp21/SNM1 subunit domain CBS PF00571.28 ETO33386.1 - 1.7e-06 28.4 0.1 0.011 16.2 0.0 2.6 2 0 0 2 2 2 2 CBS domain Voltage_CLC PF00654.20 ETO33386.1 - 0.001 18.4 3.0 0.0014 18.0 3.0 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel DUF3682 PF12446.8 ETO33386.1 - 1.4 9.4 6.9 3 8.3 6.9 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3682) TPR_12 PF13424.6 ETO33387.1 - 1.4e-83 275.2 14.1 4.2e-20 71.8 0.1 6.5 3 2 3 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33387.1 - 1.1e-75 247.7 0.9 1.8e-11 43.5 0.0 9.5 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33387.1 - 5e-58 190.7 51.0 1.2e-08 34.4 0.3 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33387.1 - 4.1e-54 176.7 20.9 7.5e-09 35.0 0.0 9.6 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33387.1 - 1.5e-45 149.6 58.8 1.6e-08 34.1 0.7 9.7 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33387.1 - 2.2e-42 139.8 37.5 9.3e-07 28.5 0.1 9.7 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33387.1 - 1.1e-27 94.4 11.1 0.0063 16.8 0.0 10.1 9 0 0 9 9 9 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33387.1 - 3e-14 53.4 0.0 0.087 13.5 0.0 7.4 6 2 1 7 7 7 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33387.1 - 2.2e-13 49.8 0.0 0.16 12.9 0.0 7.8 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO33387.1 - 7e-13 48.7 0.0 0.00063 19.2 0.0 3.3 1 1 2 3 3 3 3 MalT-like TPR region TPR_6 PF13174.6 ETO33387.1 - 5.8e-12 45.4 15.1 0.073 13.7 0.3 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33387.1 - 1.5e-11 43.8 42.8 0.0014 18.2 0.7 10.2 9 1 2 11 11 10 5 TPR repeat DUF5113 PF17140.4 ETO33387.1 - 5.2e-08 32.9 25.4 1.6 8.5 0.1 9.4 10 0 0 10 10 10 2 Domain of unknown function (DUF5113) PPR PF01535.20 ETO33387.1 - 3.5e-05 23.8 27.3 0.075 13.3 0.1 9.1 9 0 0 9 9 9 1 PPR repeat ANAPC3 PF12895.7 ETO33387.1 - 6.4e-05 23.1 23.7 0.9 9.8 0.1 6.8 1 1 7 8 8 8 4 Anaphase-promoting complex, cyclosome, subunit 3 Peptidase_C14 PF00656.22 ETO33387.1 - 0.0001 22.4 0.1 0.00031 20.8 0.1 1.7 1 1 0 1 1 1 1 Caspase domain TPR_19 PF14559.6 ETO33387.1 - 0.00072 20.0 4.3 1.9 9.0 0.0 5.4 3 2 4 7 7 7 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO33387.1 - 0.0044 17.0 39.5 0.047 13.7 0.4 8.3 9 0 0 9 9 9 3 Tetratricopeptide repeat AhpC-TSA PF00578.21 ETO33387.1 - 0.0075 16.2 0.2 0.032 14.1 0.2 2.1 1 0 0 1 1 1 1 AhpC/TSA family DUF4810 PF16068.5 ETO33387.1 - 0.009 16.5 17.0 6.9 7.3 0.3 6.6 2 1 5 7 7 7 1 Domain of unknown function (DUF4810) TPR_21 PF09976.9 ETO33387.1 - 0.016 14.9 5.9 0.47 10.1 0.2 4.2 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain Alpha-amylase_N PF02903.14 ETO33387.1 - 0.65 10.2 8.9 0.44 10.7 0.3 4.3 2 2 3 5 5 5 0 Alpha amylase, N-terminal ig-like domain Kelch_4 PF13418.6 ETO33388.1 - 0.026 14.5 0.9 0.17 11.9 0.0 2.9 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO33388.1 - 0.071 13.1 0.4 4.8 7.3 0.1 2.8 2 0 0 2 2 2 0 Kelch motif TPR_1 PF00515.28 ETO33389.1 - 1.6e-06 27.7 3.0 3.2e-05 23.6 0.2 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33389.1 - 6.5e-06 25.9 0.1 0.0049 16.9 0.1 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33389.1 - 6.6e-06 25.9 0.7 3.6e-05 23.7 0.3 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO33389.1 - 1.3e-05 25.4 0.3 3.1e-05 24.2 0.0 1.8 2 0 0 2 2 1 1 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO33389.1 - 1.4e-05 25.2 2.9 4.9e-05 23.4 2.8 2.1 1 1 0 1 1 1 1 Caspase domain TPR_7 PF13176.6 ETO33389.1 - 1.4e-05 24.7 0.0 0.00023 20.9 0.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33389.1 - 0.0012 18.7 0.0 0.019 14.9 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO33389.1 - 0.032 14.2 10.9 0.48 10.5 0.0 3.3 4 0 0 4 4 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33389.1 - 0.04 13.6 2.6 0.042 13.5 0.6 2.1 2 0 0 2 2 2 0 TPR repeat TPR_6 PF13174.6 ETO33389.1 - 0.047 14.3 0.1 0.43 11.3 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat PPR PF01535.20 ETO33389.1 - 0.28 11.5 1.0 11 6.5 0.0 3.5 3 0 0 3 3 3 0 PPR repeat FDX-ACB PF03147.14 ETO33390.1 - 0.059 13.8 0.0 0.12 12.7 0.0 1.5 1 0 0 1 1 1 0 Ferredoxin-fold anticodon binding domain DNA_pol_phi PF04931.13 ETO33391.1 - 1.2 7.2 6.6 1.9 6.5 6.6 1.3 1 0 0 1 1 1 0 DNA polymerase phi DUF2457 PF10446.9 ETO33391.1 - 1.4 8.0 8.4 2.9 6.9 8.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Sporozoite_P67 PF05642.11 ETO33391.1 - 1.6 6.7 5.3 2.4 6.1 5.3 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Pkinase PF00069.25 ETO33392.1 - 1.7e-11 44.0 0.0 1.9e-11 43.8 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33392.1 - 8.8e-05 21.9 0.0 0.00012 21.4 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Oberon_cc PF16312.5 ETO33393.1 - 0.2 11.6 0.7 0.43 10.5 0.1 1.8 2 0 0 2 2 2 0 Coiled-coil region of Oberon Asn_synthase PF00733.21 ETO33394.1 - 2.1e-36 126.3 0.0 2.7e-36 126.0 0.0 1.2 1 0 0 1 1 1 1 Asparagine synthase GATase_7 PF13537.6 ETO33394.1 - 1.3e-30 105.8 0.0 2.8e-30 104.8 0.0 1.6 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_6 PF13522.6 ETO33394.1 - 7.2e-24 84.5 0.0 1.4e-23 83.6 0.0 1.4 1 0 0 1 1 1 1 Glutamine amidotransferase domain DUF3700 PF12481.8 ETO33394.1 - 4.3e-12 46.0 0.3 4.1e-11 42.8 0.0 2.4 2 1 1 3 3 3 1 Aluminium induced protein QueC PF06508.13 ETO33394.1 - 0.0042 16.6 0.0 0.008 15.7 0.0 1.4 1 0 0 1 1 1 1 Queuosine biosynthesis protein QueC tRNA_Me_trans PF03054.16 ETO33394.1 - 0.11 11.2 0.0 0.21 10.3 0.0 1.4 1 0 0 1 1 1 0 tRNA methyl transferase NACHT PF05729.12 ETO33395.1 - 3.9e-07 30.1 0.0 8.5e-07 29.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO33395.1 - 0.0089 16.3 0.0 0.099 12.9 0.0 2.3 2 1 0 2 2 2 1 AAA domain AAA_16 PF13191.6 ETO33395.1 - 0.017 15.5 0.0 0.082 13.3 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain NB-ARC PF00931.22 ETO33395.1 - 0.024 13.9 0.0 0.024 13.9 0.0 2.5 2 2 1 3 3 3 0 NB-ARC domain FtsK_SpoIIIE PF01580.18 ETO33395.1 - 0.084 12.2 0.0 0.21 10.9 0.0 1.6 2 0 0 2 2 2 0 FtsK/SpoIIIE family PCC_BT PF18140.1 ETO33395.1 - 0.19 12.1 2.8 0.12 12.7 0.5 1.7 2 0 0 2 2 2 0 Propionyl-coenzyme A carboxylase BT domain DUF87 PF01935.17 ETO33395.1 - 0.38 10.8 5.3 0.92 9.6 0.0 2.5 2 1 0 2 2 2 0 Helicase HerA, central domain ABC_tran PF00005.27 ETO33395.1 - 0.42 11.1 4.3 0.52 10.8 0.0 2.7 1 1 1 2 2 2 0 ABC transporter RNA_helicase PF00910.22 ETO33395.1 - 1.4 9.4 5.4 1.8 9.0 0.1 3.2 1 1 2 3 3 3 0 RNA helicase BUD22 PF09073.10 ETO33397.1 - 0.04 13.3 19.3 0.06 12.7 19.3 1.2 1 0 0 1 1 1 0 BUD22 Presenilin PF01080.17 ETO33397.1 - 2.6 6.7 13.6 0.43 9.3 2.9 2.1 2 0 0 2 2 2 0 Presenilin PGA2 PF07543.12 ETO33397.1 - 4.5 7.2 20.8 0.2 11.6 9.4 2.3 2 0 0 2 2 2 0 Protein trafficking PGA2 HSP90 PF00183.18 ETO33398.1 - 1.8e-217 723.4 29.7 3.9e-217 722.2 29.7 1.5 1 1 0 1 1 1 1 Hsp90 protein DUF1987 PF09345.10 ETO33398.1 - 0.29 10.8 4.0 2.9 7.6 1.2 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1987) DJ-1_PfpI PF01965.24 ETO33399.1 - 2.5e-29 102.2 0.4 3.1e-29 101.9 0.4 1.1 1 0 0 1 1 1 1 DJ-1/PfpI family DUF4505 PF14956.6 ETO33400.1 - 0.089 12.5 0.0 0.14 11.9 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4505) TPT PF03151.16 ETO33400.1 - 0.75 9.1 11.8 0.033 13.5 2.6 2.4 2 1 0 2 2 2 0 Triose-phosphate Transporter family DUF2070 PF09843.9 ETO33400.1 - 5.1 5.3 13.7 0.81 7.9 9.5 1.6 1 1 1 2 2 2 0 Predicted membrane protein (DUF2070) Cullin PF00888.22 ETO33401.1 - 9.3e-15 54.3 3.2 4.3e-08 32.2 1.3 2.4 1 1 1 2 2 2 2 Cullin family Phage-A118_gp45 PF10653.9 ETO33401.1 - 0.0028 17.7 0.5 0.01 15.8 0.1 2.1 2 0 0 2 2 2 1 Protein gp45 of Bacteriophage A118 Sld3_N PF18523.1 ETO33401.1 - 0.0066 16.6 1.7 0.021 14.9 1.6 1.9 1 1 0 1 1 1 1 Sld3 N-terminal domain ANAPC2 PF08672.11 ETO33401.1 - 0.047 14.2 0.8 0.13 12.8 0.8 1.7 1 0 0 1 1 1 0 Anaphase promoting complex (APC) subunit 2 TBPIP PF07106.13 ETO33401.1 - 0.099 12.6 0.1 0.3 11.0 0.1 1.9 1 0 0 1 1 1 0 TBPIP/Hop2 winged helix domain DNA_pol_phi PF04931.13 ETO33401.1 - 9.1 4.2 16.3 1.3 7.0 9.1 2.3 2 0 0 2 2 2 0 DNA polymerase phi Suf PF05843.14 ETO33402.1 - 0.15 12.0 4.0 0.33 10.9 4.0 1.5 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Neur_chan_memb PF02932.16 ETO33402.1 - 0.66 10.0 10.4 0.042 13.9 1.8 2.5 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region Pex14_N PF04695.13 ETO33402.1 - 0.73 10.5 9.0 2.4 8.8 9.0 1.9 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region Striatin PF08232.12 ETO33402.1 - 1.3 9.6 10.5 0.21 12.2 4.5 2.4 2 0 0 2 2 2 0 Striatin family Serpin PF00079.20 ETO33403.1 - 2.5e-13 50.1 0.0 3e-13 49.8 0.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) Serpin PF00079.20 ETO33404.1 - 4.3e-13 49.3 2.0 5e-13 49.1 2.0 1.1 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) DDHD PF02862.17 ETO33404.1 - 0.011 15.9 0.1 0.02 15.0 0.1 1.4 1 1 0 1 1 1 0 DDHD domain FAM176 PF14851.6 ETO33404.1 - 0.077 12.7 3.0 0.12 12.0 3.0 1.5 1 0 0 1 1 1 0 FAM176 family Tim54 PF11711.8 ETO33404.1 - 0.089 11.6 3.2 0.12 11.1 3.2 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 DUF913 PF06025.12 ETO33404.1 - 0.092 11.7 2.0 0.12 11.3 2.0 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 ETO33404.1 - 0.12 10.6 5.3 0.14 10.4 5.3 1.1 1 0 0 1 1 1 0 CDC45-like protein TRAP_alpha PF03896.16 ETO33404.1 - 0.26 10.5 5.5 0.38 9.9 5.5 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF4337 PF14235.6 ETO33404.1 - 0.46 10.6 2.2 0.8 9.8 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) Vfa1 PF08432.10 ETO33404.1 - 0.53 10.6 11.6 0.39 11.0 6.9 2.2 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 DUF4820 PF16091.5 ETO33404.1 - 0.62 9.4 4.5 1.1 8.6 4.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) DUF4637 PF15470.6 ETO33404.1 - 1.7 8.3 9.7 2.7 7.7 9.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CobT PF06213.12 ETO33404.1 - 2 7.8 13.4 3.1 7.1 13.4 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2203 PF09969.9 ETO33404.1 - 3.3 8.5 7.7 8.3 7.2 4.6 2.1 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF5399 PF17377.2 ETO33404.1 - 4.9 7.0 8.4 2.5 7.9 0.0 2.4 2 0 0 2 2 2 0 Family of unknown function (DUF5399) Kelch_1 PF01344.25 ETO33405.1 - 7e-06 25.5 1.6 0.00023 20.7 0.0 2.8 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO33405.1 - 0.00034 20.8 0.3 0.001 19.3 0.0 2.0 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO33405.1 - 0.0005 20.0 0.2 0.0022 18.0 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33405.1 - 0.00055 20.1 1.9 0.00084 19.5 0.0 2.3 3 0 0 3 3 3 1 Kelch motif DUF4667 PF15700.5 ETO33405.1 - 0.066 13.3 17.3 0.11 12.6 16.4 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF4667) DUF515 PF04415.12 ETO33405.1 - 0.38 9.1 9.0 0.63 8.4 9.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF515) DUF3446 PF11928.8 ETO33405.1 - 1.9 8.9 22.3 0.07 13.4 14.7 2.4 3 0 0 3 3 3 0 Early growth response N-terminal domain WD40 PF00400.32 ETO33406.1 - 2.4e-05 25.0 4.4 0.00015 22.5 0.5 3.3 3 1 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO33406.1 - 0.0014 17.4 0.0 0.0014 17.4 0.0 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ATP-synt_8 PF00895.20 ETO33407.1 - 0.091 13.2 3.0 0.26 11.8 3.0 1.8 1 0 0 1 1 1 0 ATP synthase protein 8 7TM_GPCR_Srw PF10324.9 ETO33407.1 - 0.096 11.9 0.0 0.16 11.2 0.0 1.3 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srw LRR_4 PF12799.7 ETO33408.1 - 3.4e-08 33.6 11.9 0.0014 18.9 0.4 3.7 3 1 0 3 3 3 3 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO33408.1 - 8.9e-05 22.2 14.4 0.00021 21.0 0.1 4.1 4 1 1 5 5 5 2 Leucine rich repeat LRR_6 PF13516.6 ETO33408.1 - 0.023 14.7 1.7 2.1 8.6 0.2 2.7 2 0 0 2 2 2 0 Leucine Rich repeat LRR_1 PF00560.33 ETO33408.1 - 0.26 12.0 14.1 2.6 8.9 0.1 5.7 4 3 1 5 5 5 0 Leucine Rich Repeat LRR_4 PF12799.7 ETO33409.1 - 0.048 14.1 1.9 8 7.0 0.1 3.6 3 1 0 3 3 3 0 Leucine Rich repeats (2 copies) TPR_14 PF13428.6 ETO33411.1 - 8.9e-08 32.3 0.1 0.2 12.6 0.0 3.9 2 1 2 4 4 4 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33411.1 - 9.3e-07 28.5 0.7 0.17 12.1 0.0 4.4 4 1 0 4 4 4 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33411.1 - 2.4e-06 27.5 5.5 0.034 14.5 0.2 3.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO33411.1 - 3.8e-06 27.3 0.0 0.16 12.5 0.0 3.0 2 2 1 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33411.1 - 1.8e-05 24.3 0.9 0.0047 16.7 0.1 3.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33411.1 - 3.1e-05 23.6 0.3 0.027 14.2 0.1 3.3 2 1 1 3 3 3 1 TPR repeat TPR_9 PF13371.6 ETO33411.1 - 0.00012 22.1 0.1 0.0016 18.6 0.5 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO33411.1 - 0.00013 21.9 1.7 0.0066 16.5 0.0 3.0 3 0 0 3 3 3 1 Fis1 C-terminal tetratricopeptide repeat TPR_7 PF13176.6 ETO33411.1 - 0.006 16.5 0.3 4.3 7.6 0.0 3.5 3 0 0 3 3 3 1 Tetratricopeptide repeat HrpB1_HrpK PF09613.10 ETO33411.1 - 0.01 15.5 0.1 0.34 10.5 0.0 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB1_HrpK) TPR_6 PF13174.6 ETO33411.1 - 0.014 16.0 1.0 3.7 8.4 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33411.1 - 0.02 15.5 0.0 2.5 8.8 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat SPESP1 PF15754.5 ETO33411.1 - 0.058 12.6 0.3 0.081 12.1 0.3 1.2 1 0 0 1 1 1 0 Sperm equatorial segment protein 1 TPR_12 PF13424.6 ETO33411.1 - 0.11 12.8 3.0 1.7 9.0 1.9 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO33411.1 - 0.27 11.5 5.9 0.78 10.0 0.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 CDC45 PF02724.14 ETO33412.1 - 1.4 7.1 15.6 0.21 9.8 12.2 1.3 1 1 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ETO33412.1 - 2.9 6.2 8.0 0.56 8.5 4.7 1.4 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 MADF_DNA_bdg PF10545.9 ETO33412.1 - 3.7 7.9 9.5 3.6 8.0 7.5 2.2 1 1 1 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like 7tm_3 PF00003.22 ETO33415.1 - 0.0019 18.0 9.7 0.0019 18.0 9.7 1.4 2 0 0 2 2 2 1 7 transmembrane sweet-taste receptor of 3 GCPR zf-RING_UBOX PF13445.6 ETO33416.1 - 0.001 19.0 0.1 0.002 18.1 0.1 1.5 1 0 0 1 1 1 1 RING-type zinc-finger zf-RING_5 PF14634.6 ETO33416.1 - 0.012 15.6 0.2 0.025 14.6 0.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO33416.1 - 0.024 14.5 0.3 0.059 13.3 0.3 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO33416.1 - 0.031 14.1 0.4 0.062 13.2 0.4 1.5 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO33416.1 - 0.059 13.2 0.8 0.11 12.4 0.8 1.4 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 Ion_trans PF00520.31 ETO33417.1 - 2.2e-15 56.6 8.3 2.2e-15 56.6 8.3 2.1 2 1 0 2 2 2 1 Ion transport protein PKD_channel PF08016.12 ETO33417.1 - 1.6e-08 33.6 7.5 3.9e-08 32.4 7.5 1.6 1 1 0 1 1 1 1 Polycystin cation channel DUF2157 PF09925.9 ETO33417.1 - 0.12 12.1 4.1 1.8 8.3 4.1 2.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2157) TraP PF07296.11 ETO33417.1 - 0.62 9.2 3.4 0.39 9.9 0.2 2.2 2 0 0 2 2 2 0 TraP protein DUF4653 PF15546.6 ETO33419.1 - 0.5 9.9 0.1 0.5 9.9 0.1 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF4653) tRNA-synt_2d PF01409.20 ETO33420.1 - 1.1e-16 61.1 0.0 2.1e-16 60.2 0.0 1.5 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) FDX-ACB PF03147.14 ETO33420.1 - 1.5e-13 51.0 0.0 3.1e-13 50.0 0.0 1.4 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain MIT_C PF16565.5 ETO33421.1 - 0.031 14.2 0.3 0.046 13.7 0.3 1.2 1 0 0 1 1 1 0 Phospholipase D-like domain at C-terminus of MIT Drf_FH1 PF06346.12 ETO33422.1 - 0.0072 16.1 0.8 0.011 15.4 0.8 1.2 1 0 0 1 1 1 1 Formin Homology Region 1 PIG-F PF06699.11 ETO33422.1 - 0.037 14.2 0.0 0.053 13.7 0.0 1.2 1 0 0 1 1 1 0 GPI biosynthesis protein family Pig-F Kelch_6 PF13964.6 ETO33424.1 - 9.9e-10 38.4 0.4 0.00015 21.9 0.2 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO33424.1 - 0.00086 19.2 0.1 0.28 11.2 0.1 3.6 5 0 0 5 5 5 1 Kelch motif Kelch_3 PF13415.6 ETO33424.1 - 0.0036 17.5 0.7 0.11 12.8 0.0 3.3 3 0 0 3 3 3 1 Galactose oxidase, central domain WD40 PF00400.32 ETO33425.1 - 7.6e-57 188.0 16.9 3.9e-09 37.0 0.0 7.0 7 0 0 7 7 7 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO33425.1 - 1.1e-12 47.6 0.1 0.029 13.4 0.0 5.6 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO33425.1 - 5.6e-12 45.8 2.7 0.0083 16.4 0.0 5.7 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO33425.1 - 0.00016 21.5 0.5 4.1 7.5 0.0 5.2 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO33425.1 - 0.0028 17.1 0.0 1.6 8.0 0.0 3.3 3 1 1 4 4 4 1 WD40-like domain DPPIV_N PF00930.21 ETO33425.1 - 0.0031 16.3 0.2 0.43 9.3 0.0 3.4 1 1 2 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nup160 PF11715.8 ETO33425.1 - 0.0053 15.5 3.6 5 5.7 0.1 4.5 2 1 2 5 5 5 1 Nucleoporin Nup120/160 VID27 PF08553.10 ETO33425.1 - 0.028 13.5 0.0 1.2 8.1 0.0 2.4 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain Proteasome_A_N PF10584.9 ETO33425.1 - 0.029 14.0 3.0 25 4.7 0.0 4.7 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature NHL PF01436.21 ETO33425.1 - 0.098 12.7 0.3 38 4.6 0.0 3.7 4 0 0 4 4 4 0 NHL repeat WD40 PF00400.32 ETO33426.1 - 2.5e-28 97.8 33.1 2.9e-05 24.7 0.4 8.1 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33426.1 - 2.2e-08 34.3 2.2 0.28 11.5 0.1 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33426.1 - 1e-05 24.4 6.4 0.088 11.4 0.1 4.5 2 2 3 5 5 5 3 Nucleoporin Nup120/160 Kelch_2 PF07646.15 ETO33426.1 - 4.4 7.4 7.0 9.4 6.4 0.1 4.1 5 0 0 5 5 5 0 Kelch motif CAP_GLY PF01302.25 ETO33429.1 - 7.1e-19 67.6 0.3 2.1e-18 66.1 0.3 1.8 1 0 0 1 1 1 1 CAP-Gly domain WD40 PF00400.32 ETO33431.1 - 2.4e-51 170.6 13.3 6.1e-08 33.2 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33431.1 - 2.9e-11 43.5 3.8 0.019 15.3 0.0 5.7 1 1 5 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33431.1 - 6.1e-11 41.9 0.3 1.9 7.4 0.0 5.9 2 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33431.1 - 2.8e-05 23.6 4.2 0.042 13.2 0.8 3.1 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO33431.1 - 7.8e-05 21.5 5.9 1.3 7.5 0.1 5.2 2 1 4 6 6 6 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO33431.1 - 0.00027 19.6 0.4 0.016 13.7 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO33431.1 - 0.0023 17.3 0.4 5.7 6.2 0.1 3.6 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal PALB2_WD40 PF16756.5 ETO33431.1 - 0.0057 15.6 3.1 0.092 11.7 0.1 3.1 1 1 1 2 2 2 1 Partner and localizer of BRCA2 WD40 domain VID27 PF08553.10 ETO33431.1 - 0.0063 15.6 0.1 0.11 11.5 0.0 2.3 2 1 0 2 2 2 1 VID27 C-terminal WD40-like domain Vac_Fusion PF02346.16 ETO33431.1 - 0.014 15.0 0.2 11 5.7 0.0 4.1 5 0 0 5 5 5 0 Chordopoxvirus multifunctional envelope protein A27 Invas_SpaK PF03519.14 ETO33431.1 - 0.025 14.7 8.6 0.96 9.6 0.1 3.7 4 0 0 4 4 4 0 Invasion protein B family NodS PF05401.11 ETO33431.1 - 0.025 14.2 0.2 3.1 7.4 0.0 2.9 2 1 0 2 2 2 0 Nodulation protein S (NodS) SBD PF17882.1 ETO33431.1 - 0.086 12.7 0.1 17 5.3 0.0 2.8 2 1 1 3 3 3 0 OAA-family lectin sugar binding domain HARP PF07443.13 ETO33431.1 - 0.091 12.4 0.1 3.7 7.3 0.0 3.5 5 0 0 5 5 5 0 HepA-related protein (HARP) Nucleoporin_N PF08801.11 ETO33431.1 - 0.56 8.9 9.0 2.8 6.6 4.4 3.2 1 1 0 2 2 2 0 Nup133 N terminal like PD40 PF07676.12 ETO33431.1 - 1.2 9.2 4.3 21 5.2 0.0 4.0 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Ras PF00071.22 ETO33432.1 - 6.8e-33 113.5 0.1 1.4e-32 112.6 0.0 1.5 1 1 1 2 2 2 1 Ras family Roc PF08477.13 ETO33432.1 - 2.5e-17 63.2 0.2 2.5e-17 63.2 0.2 1.5 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO33432.1 - 1.4e-07 31.1 0.1 2e-07 30.6 0.1 1.2 1 0 0 1 1 1 1 ADP-ribosylation factor family AAA_15 PF13175.6 ETO33432.1 - 0.0016 18.2 0.0 0.0026 17.6 0.0 1.3 1 1 0 1 1 1 1 AAA ATPase domain FeoB_N PF02421.18 ETO33432.1 - 0.0037 16.8 0.1 0.013 15.0 0.1 1.8 1 1 0 1 1 1 1 Ferrous iron transport protein B TniB PF05621.11 ETO33432.1 - 0.019 14.4 0.0 0.036 13.5 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein MMR_HSR1 PF01926.23 ETO33432.1 - 0.023 14.8 0.2 0.066 13.3 0.2 2.0 1 1 0 1 1 1 0 50S ribosome-binding GTPase PHB_acc PF05233.13 ETO33432.1 - 0.071 13.1 0.1 0.14 12.2 0.1 1.5 1 0 0 1 1 1 0 PHB accumulation regulatory domain DEAD PF00270.29 ETO33433.1 - 4.1e-19 69.0 0.0 9.7e-19 67.8 0.0 1.6 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO33433.1 - 0.00012 22.2 0.1 0.00041 20.4 0.1 2.1 1 1 0 1 1 1 1 Type III restriction enzyme, res subunit AAA_22 PF13401.6 ETO33433.1 - 0.0087 16.3 0.0 0.038 14.3 0.0 2.1 2 1 0 2 2 2 1 AAA domain T2SSE PF00437.20 ETO33433.1 - 0.031 13.3 0.0 0.051 12.6 0.0 1.3 1 0 0 1 1 1 0 Type II/IV secretion system protein DUF1631 PF07793.11 ETO33433.1 - 0.041 12.3 0.2 0.085 11.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1631) Lipoprotein_X PF03305.13 ETO33433.1 - 0.053 13.3 0.9 2.4 7.9 0.2 2.2 2 0 0 2 2 2 0 Mycoplasma MG185/MG260 protein ATPase_2 PF01637.18 ETO33433.1 - 0.094 12.6 2.5 0.14 12.0 0.1 2.2 1 1 1 2 2 2 0 ATPase domain predominantly from Archaea KTI12 PF08433.10 ETO33433.1 - 0.13 11.7 3.6 0.88 9.0 1.1 2.2 1 1 0 2 2 2 0 Chromatin associated protein KTI12 2TM PF13239.6 ETO33435.1 - 7.9 6.9 9.5 4.2 7.7 1.3 2.3 2 1 0 2 2 2 0 2TM domain ABC_tran PF00005.27 ETO33436.1 - 1.4e-19 71.0 0.1 2.3e-19 70.3 0.1 1.3 1 0 0 1 1 1 1 ABC transporter SMC_N PF02463.19 ETO33436.1 - 6.8e-06 25.7 0.3 9.2e-06 25.2 0.3 1.2 1 0 0 1 1 1 1 RecF/RecN/SMC N terminal domain NTPase_1 PF03266.15 ETO33436.1 - 0.015 15.2 0.3 0.021 14.7 0.3 1.3 1 0 0 1 1 1 0 NTPase OstA_2 PF13100.6 ETO33436.1 - 0.029 14.0 0.2 0.84 9.2 0.2 2.2 2 0 0 2 2 2 0 OstA-like protein SbcCD_C PF13558.6 ETO33436.1 - 0.029 14.6 3.5 0.21 11.8 1.1 2.7 2 1 0 2 2 2 0 Putative exonuclease SbcCD, C subunit RepB-RCR_reg PF10723.9 ETO33436.1 - 0.11 12.4 0.1 0.44 10.5 0.0 2.1 2 0 0 2 2 2 0 Replication regulatory protein RepB DUF1764 PF08576.10 ETO33438.1 - 0.0048 17.8 0.8 0.0099 16.8 0.8 1.4 1 0 0 1 1 1 1 Eukaryotic protein of unknown function (DUF1764) WD40 PF00400.32 ETO33439.1 - 0.00021 22.0 0.4 0.045 14.6 0.1 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33439.1 - 0.00056 20.2 0.0 0.22 11.9 0.0 2.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Alpha_kinase PF02816.18 ETO33442.1 - 5.3e-10 39.7 3.5 5.3e-10 39.7 3.5 2.7 2 1 0 2 2 2 1 Alpha-kinase family LRR_4 PF12799.7 ETO33442.1 - 3.4e-07 30.5 17.5 0.003 18.0 3.2 4.6 4 0 0 4 4 4 3 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ETO33442.1 - 4.7e-06 26.2 4.2 0.051 13.1 1.0 3.3 3 0 0 3 3 3 2 Leucine-rich repeat LRR_8 PF13855.6 ETO33442.1 - 3.5e-05 23.5 9.3 0.00033 20.4 1.4 3.8 3 0 0 3 3 3 2 Leucine rich repeat Orf78 PF06024.12 ETO33442.1 - 0.22 11.9 0.0 0.22 11.9 0.0 3.2 4 0 0 4 4 4 0 Orf78 (ac78) Exo_endo_phos_2 PF14529.6 ETO33443.1 - 9.6e-05 22.2 0.2 0.00014 21.7 0.2 1.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase Peptidase_C36 PF05415.11 ETO33443.1 - 0.11 12.7 0.0 0.17 12.1 0.0 1.3 1 0 0 1 1 1 0 Beet necrotic yellow vein furovirus-type papain-like endopeptidase WD40 PF00400.32 ETO33444.1 - 2.6e-15 56.5 20.7 6.4e-06 26.8 0.1 6.2 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33444.1 - 3.3e-05 24.1 0.2 0.019 15.3 0.0 3.1 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DAGAT PF03982.13 ETO33445.1 - 0.053 12.4 0.1 0.073 12.0 0.1 1.2 1 0 0 1 1 1 0 Diacylglycerol acyltransferase RNA_polI_A34 PF08208.11 ETO33445.1 - 0.61 10.1 16.3 0.74 9.9 16.3 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase I subunit RPA34.5 BRF1 PF07741.13 ETO33445.1 - 1 9.7 18.7 7.1 7.0 18.7 1.9 1 1 0 1 1 1 0 Brf1-like TBP-binding domain WD40 PF00400.32 ETO33446.1 - 9.9e-14 51.5 12.2 0.012 16.4 0.1 5.4 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33446.1 - 0.00014 22.1 1.1 1.6 9.1 0.1 3.9 2 2 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain LisH PF08513.11 ETO33447.1 - 3.6e-05 23.5 0.4 6.7e-05 22.7 0.4 1.5 1 0 0 1 1 1 1 LisH TINF2_N PF14973.6 ETO33447.1 - 0.0032 17.8 0.5 0.0032 17.8 0.5 1.6 2 0 0 2 2 2 1 TERF1-interacting nuclear factor 2 N-terminus Peptidase_M23_N PF18421.1 ETO33447.1 - 0.032 14.1 0.0 0.072 13.0 0.0 1.5 1 0 0 1 1 1 0 Peptidase family M23 N-terminal domain Cu2_monoox_C PF03712.15 ETO33447.1 - 0.064 12.8 0.4 0.24 10.9 0.1 2.0 1 1 0 2 2 2 0 Copper type II ascorbate-dependent monooxygenase, C-terminal domain DUF898 PF05987.13 ETO33448.1 - 0.06 12.4 4.5 0.09 11.8 4.5 1.2 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF898) PNISR PF15996.5 ETO33449.1 - 2 8.7 12.3 2.5 8.3 12.3 1.2 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR PPL5 PF18168.1 ETO33449.1 - 2.3 7.5 9.9 2.5 7.3 9.9 1.0 1 0 0 1 1 1 0 Prim-pol family 5 FAM76 PF16046.5 ETO33449.1 - 2.9 7.2 12.2 3.5 6.9 12.2 1.0 1 0 0 1 1 1 0 FAM76 protein SLC12 PF03522.15 ETO33449.1 - 7.5 5.4 11.0 8.4 5.3 11.0 1.0 1 0 0 1 1 1 0 Solute carrier family 12 PPP4R2 PF09184.11 ETO33449.1 - 9.5 5.7 23.0 11 5.5 23.0 1.1 1 0 0 1 1 1 0 PPP4R2 SAM_2 PF07647.17 ETO33450.1 - 0.055 13.6 0.0 0.075 13.2 0.0 1.2 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) HSP90 PF00183.18 ETO33451.1 - 1.3e-39 136.5 8.0 7.9e-35 120.7 2.8 2.2 2 0 0 2 2 2 2 Hsp90 protein Methyltr_RsmB-F PF01189.17 ETO33451.1 - 0.003 17.2 0.0 0.0073 16.0 0.0 1.6 1 0 0 1 1 1 1 16S rRNA methyltransferase RsmB/F zinc_ribbon_15 PF17032.5 ETO33451.1 - 0.36 11.6 8.6 0.35 11.7 5.7 2.5 1 1 1 2 2 2 0 zinc-ribbon family T_Ag_DNA_bind PF02217.16 ETO33452.1 - 0.039 14.6 0.0 0.26 11.9 0.0 2.0 1 1 1 2 2 2 0 Origin of replication binding protein FlaG PF03646.15 ETO33452.1 - 0.045 13.9 0.7 0.075 13.2 0.7 1.3 1 0 0 1 1 1 0 FlaG protein TF_Zn_Ribbon PF08271.12 ETO33453.1 - 0.015 14.8 1.9 0.015 14.8 1.9 2.1 2 0 0 2 2 2 0 TFIIB zinc-binding ZZ PF00569.17 ETO33453.1 - 0.02 14.7 4.7 0.048 13.5 4.7 1.6 1 0 0 1 1 1 0 Zinc finger, ZZ type zf-ribbon_3 PF13248.6 ETO33453.1 - 0.22 11.0 8.1 0.038 13.4 3.4 2.0 2 0 0 2 2 2 0 zinc-ribbon domain Rubredoxin_2 PF18073.1 ETO33453.1 - 1.6 8.5 12.2 4 7.2 6.5 2.4 2 0 0 2 2 2 0 Rubredoxin metal binding domain TPR_12 PF13424.6 ETO33455.1 - 1.8e-29 101.9 11.9 8.8e-12 45.1 0.4 4.3 2 1 2 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33455.1 - 5.4e-15 54.7 2.3 0.0017 18.1 0.0 5.4 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33455.1 - 1.1e-10 40.8 25.9 0.011 15.6 0.4 6.0 5 1 0 5 5 5 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33455.1 - 9.6e-10 37.9 23.9 0.0015 18.6 0.3 6.3 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33455.1 - 3.5e-09 36.1 3.7 0.41 10.8 0.1 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33455.1 - 5e-09 35.6 19.4 0.061 13.5 0.1 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33455.1 - 0.00029 21.3 8.3 0.46 11.2 0.0 4.6 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33455.1 - 0.00045 20.8 0.8 42 5.3 0.0 4.9 4 1 1 5 5 5 0 Tetratricopeptide repeat DUF2225 PF09986.9 ETO33455.1 - 0.012 15.4 10.1 0.029 14.1 1.7 2.8 1 1 2 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_17 PF13431.6 ETO33455.1 - 0.046 14.1 0.7 1.9 9.0 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33455.1 - 0.51 11.0 1.3 51 4.6 0.0 3.4 4 0 0 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO33455.1 - 0.69 10.7 7.6 1.7 9.5 0.2 3.6 3 0 0 3 3 3 0 Sel1 repeat MIT PF04212.18 ETO33455.1 - 5.5 7.1 13.6 20 5.3 0.1 4.9 5 0 0 5 5 5 0 MIT (microtubule interacting and transport) domain WD40 PF00400.32 ETO33456.1 - 3.1e-18 65.8 10.1 2.4e-06 28.2 0.5 3.9 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33456.1 - 0.00016 21.9 0.5 0.5 10.7 0.0 3.5 2 2 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33456.1 - 0.0011 17.7 0.8 0.58 8.7 0.0 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 PUB PF09409.10 ETO33457.1 - 0.031 14.2 1.0 0.031 14.2 1.0 3.0 2 2 0 2 2 2 0 PUB domain TPR_12 PF13424.6 ETO33459.1 - 1.2e-06 28.7 0.2 2.2e-06 27.9 0.2 1.4 1 0 0 1 1 1 1 Tetratricopeptide repeat Lge1 PF11488.8 ETO33459.1 - 0.14 12.3 2.2 10 6.4 0.7 3.4 3 0 0 3 3 3 0 Transcriptional regulatory protein LGE1 TPR_10 PF13374.6 ETO33459.1 - 0.53 10.2 1.7 1.9 8.5 0.1 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat DndB PF14072.6 ETO33460.1 - 0.032 13.5 0.4 0.039 13.2 0.4 1.2 1 0 0 1 1 1 0 DNA-sulfur modification-associated SCRG1 PF15224.6 ETO33461.1 - 0.097 12.8 0.7 1.4 9.1 0.3 2.5 2 1 1 3 3 3 0 Scrapie-responsive protein 1 LMBR1 PF04791.16 ETO33462.1 - 5.3 5.8 11.8 6.8 5.5 11.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein WD40 PF00400.32 ETO33464.1 - 4.9e-46 153.8 21.0 3.8e-07 30.7 0.2 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33464.1 - 8e-13 48.5 0.2 0.00037 20.7 0.0 5.4 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33464.1 - 4.3e-06 25.7 6.4 0.24 10.0 0.2 5.1 2 1 4 6 6 6 4 Nucleoporin Nup120/160 CCDC144C PF14915.6 ETO33464.1 - 0.024 13.8 3.1 0.034 13.3 3.1 1.1 1 0 0 1 1 1 0 CCDC144C protein coiled-coil region C2 PF00168.30 ETO33466.1 - 6.1e-06 26.5 0.0 1.3e-05 25.4 0.0 1.6 1 0 0 1 1 1 1 C2 domain IBR PF01485.21 ETO33467.1 - 9.5e-19 67.4 38.6 2.4e-12 46.9 13.2 3.9 4 0 0 4 4 4 2 IBR domain, a half RING-finger domain zf-C3HC4_3 PF13920.6 ETO33467.1 - 0.0085 15.9 23.4 0.03 14.2 0.5 5.3 4 0 0 4 4 4 2 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO33467.1 - 0.14 12.1 0.1 0.14 12.1 0.1 5.6 5 1 0 5 5 5 0 Zinc finger, C3HC4 type (RING finger) KxDL PF10241.9 ETO33467.1 - 0.26 11.6 4.4 0.17 12.2 0.6 2.5 2 1 0 2 2 2 0 Uncharacterized conserved protein zf-RING_11 PF17123.5 ETO33467.1 - 8.9 6.2 10.3 0.25 11.1 1.0 3.4 3 0 0 3 3 3 0 RING-like zinc finger Tetraspanin PF00335.20 ETO33468.1 - 0.12 12.1 5.4 0.28 10.9 5.4 1.6 1 1 0 1 1 1 0 Tetraspanin family WD40 PF00400.32 ETO33469.1 - 9.7e-33 111.7 24.8 7.3e-08 33.0 0.4 8.5 8 1 0 8 8 8 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO33469.1 - 4.3e-09 35.6 8.8 0.02 13.6 0.0 5.5 2 1 4 7 7 7 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33469.1 - 3.2e-08 33.8 0.7 0.76 10.1 0.0 5.6 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO33469.1 - 2.7e-07 31.2 2.1 2.7e-07 31.2 2.1 2.9 2 0 0 2 2 2 1 TRAF-type zinc finger MAGSP PF03082.14 ETO33469.1 - 0.049 13.2 5.7 0.089 12.4 5.7 1.4 1 0 0 1 1 1 0 Male accessory gland secretory protein WD40_like PF17005.5 ETO33469.1 - 0.066 12.5 0.2 0.066 12.5 0.2 4.0 3 1 1 4 4 4 0 WD40-like domain FAA_hydrolase_N PF09298.11 ETO33469.1 - 0.42 10.8 1.7 0.92 9.7 1.7 1.5 1 0 0 1 1 1 0 Fumarylacetoacetase N-terminal DUF641 PF04859.12 ETO33469.1 - 0.99 9.7 13.0 0.27 11.6 9.8 1.8 2 0 0 2 2 2 0 Plant protein of unknown function (DUF641) Golgin_A5 PF09787.9 ETO33469.1 - 1.3 8.4 20.0 0.24 10.8 16.3 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 YscO-like PF16789.5 ETO33469.1 - 8.5 6.4 21.9 6.1 6.9 17.5 2.3 1 1 1 2 2 2 0 YscO-like protein DTC PF18102.1 ETO33470.1 - 5.3e-46 156.1 0.0 1e-45 155.1 0.0 1.5 1 0 0 1 1 1 1 Deltex C-terminal domain Atrophin-1 PF03154.15 ETO33471.1 - 3.5e-08 32.3 10.2 5.3e-08 31.7 10.2 1.3 1 0 0 1 1 1 1 Atrophin-1 family zf-BED PF02892.15 ETO33471.1 - 0.21 11.6 0.2 0.41 10.7 0.2 1.5 1 0 0 1 1 1 0 BED zinc finger Cas_Csy4 PF09618.10 ETO33471.1 - 0.31 11.1 9.6 0.56 10.3 9.6 1.3 1 0 0 1 1 1 0 CRISPR-associated protein (Cas_Csy4) O-antigen_lig PF13425.6 ETO33471.1 - 3.4 6.3 6.3 5.2 5.7 6.3 1.4 1 0 0 1 1 1 0 O-antigen ligase like membrane protein V_ATPase_I PF01496.19 ETO33471.1 - 4.2 5.2 13.9 0.33 8.8 9.6 1.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Golgin_A5 PF09787.9 ETO33471.1 - 6.7 6.1 28.6 0.65 9.4 24.0 1.5 2 0 0 2 2 2 0 Golgin subfamily A member 5 AAA_23 PF13476.6 ETO33471.1 - 6.7 7.2 22.8 2.6 8.5 16.9 2.1 2 0 0 2 2 2 0 AAA domain MCLC PF05934.11 ETO33472.1 - 5.5 5.6 6.9 6 5.5 6.9 1.0 1 0 0 1 1 1 0 Mid-1-related chloride channel (MCLC) WD40 PF00400.32 ETO33474.1 - 7.8e-24 83.5 22.7 9.6e-08 32.6 0.6 6.5 5 2 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33474.1 - 3.8e-10 39.9 0.5 0.0002 21.6 0.0 4.1 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33474.1 - 5.7e-10 38.5 0.7 0.0045 15.7 0.0 3.9 1 1 2 4 4 4 4 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO33474.1 - 0.049 13.9 0.1 0.96 9.7 0.0 2.6 2 1 1 3 3 3 0 Domain of unknown function (DUF4979) Lipase_3 PF01764.25 ETO33475.1 - 1.7e-18 66.8 0.0 4.4e-18 65.5 0.0 1.7 1 0 0 1 1 1 1 Lipase (class 3) Abhydrolase_3 PF07859.13 ETO33475.1 - 0.01 15.7 0.0 0.024 14.5 0.0 1.6 1 0 0 1 1 1 0 alpha/beta hydrolase fold PGAP1 PF07819.13 ETO33475.1 - 0.064 13.0 0.0 0.15 11.8 0.0 1.6 1 0 0 1 1 1 0 PGAP1-like protein Abhydrolase_2 PF02230.16 ETO33475.1 - 0.068 13.0 0.5 0.12 12.2 0.0 1.5 2 0 0 2 2 2 0 Phospholipase/Carboxylesterase DUF4294 PF14127.6 ETO33475.1 - 0.44 10.5 0.1 0.44 10.5 0.1 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4294) RPN2_C PF18004.1 ETO33476.1 - 5.9e-40 136.8 9.5 5.9e-40 136.8 9.5 1.5 2 0 0 2 2 2 1 26S proteasome regulatory subunit RPN2 C-terminal domain Vfa1 PF08432.10 ETO33476.1 - 8.2 6.7 13.0 17 5.7 13.0 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sec62 PF03839.16 ETO33476.1 - 8.8 5.8 6.4 18 4.7 6.4 1.6 1 0 0 1 1 1 0 Translocation protein Sec62 Tropomyosin_1 PF12718.7 ETO33477.1 - 0.0011 19.1 10.5 0.0018 18.5 10.5 1.3 1 0 0 1 1 1 1 Tropomyosin like YscO PF07321.12 ETO33477.1 - 0.0023 17.9 2.3 0.08 12.9 1.6 2.2 2 0 0 2 2 2 1 Type III secretion protein YscO SlyX PF04102.12 ETO33477.1 - 0.019 15.6 3.1 0.063 13.9 3.1 1.9 1 0 0 1 1 1 0 SlyX DUF2852 PF11014.8 ETO33477.1 - 0.1 12.8 0.6 0.19 11.9 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2852) Med4 PF10018.9 ETO33477.1 - 0.1 12.3 5.7 0.16 11.7 5.7 1.3 1 0 0 1 1 1 0 Vitamin-D-receptor interacting Mediator subunit 4 YqzL PF14006.6 ETO33477.1 - 0.12 12.7 0.2 0.51 10.7 0.0 2.2 2 0 0 2 2 2 0 YqzL-like protein DUF4122 PF13498.6 ETO33477.1 - 0.13 12.0 3.9 0.19 11.4 3.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4122) Striatin PF08232.12 ETO33477.1 - 0.14 12.8 5.9 0.19 12.3 5.9 1.3 1 0 0 1 1 1 0 Striatin family CSRNP_N PF16019.5 ETO33477.1 - 0.33 10.8 4.7 0.61 10.0 4.7 1.3 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus LMBR1 PF04791.16 ETO33477.1 - 0.46 9.3 6.1 0.53 9.1 6.1 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Rop-like PF05082.13 ETO33477.1 - 0.72 9.7 4.5 0.18 11.6 0.7 1.9 2 0 0 2 2 2 0 Rop-like Exonuc_VII_L PF02601.15 ETO33477.1 - 0.78 9.3 8.2 0.86 9.1 8.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Ank_2 PF12796.7 ETO33479.1 - 0.0012 19.4 0.0 0.22 12.2 0.0 3.2 2 1 1 3 3 3 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO33479.1 - 0.0022 18.3 0.2 3.3 8.6 0.0 4.1 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO33479.1 - 0.0026 18.3 0.1 1 10.0 0.0 2.9 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO33479.1 - 0.017 15.6 0.1 9.3 6.9 0.0 2.8 2 0 0 2 2 2 0 Ankyrin repeat Ank_5 PF13857.6 ETO33479.1 - 0.018 15.3 0.0 7.8 7.0 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) TetR_C_23 PF17931.1 ETO33479.1 - 0.68 10.1 4.8 0.31 11.2 2.0 1.8 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain FliT PF05400.13 ETO33479.1 - 9.8 7.1 13.8 6.3 7.7 4.4 2.5 2 0 0 2 2 2 0 Flagellar protein FliT RNF220 PF15926.5 ETO33480.1 - 0.019 14.6 0.6 0.022 14.4 0.6 1.2 1 0 0 1 1 1 0 E3 ubiquitin-protein ligase RNF220 DUF3290 PF11694.8 ETO33480.1 - 0.06 13.3 2.8 0.069 13.1 2.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3290) Pkinase PF00069.25 ETO33481.1 - 2.2e-45 155.1 0.0 2.6e-41 141.7 0.0 2.1 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33481.1 - 2.5e-20 72.8 0.0 5.2e-20 71.8 0.0 1.4 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO33481.1 - 0.00098 18.5 0.0 0.0015 17.9 0.0 1.2 1 0 0 1 1 1 1 Kinase-like Pkinase_fungal PF17667.1 ETO33481.1 - 0.011 14.5 0.0 0.014 14.2 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase PAE PF03283.13 ETO33482.1 - 1.4e-10 40.8 0.1 1.9e-10 40.4 0.1 1.1 1 0 0 1 1 1 1 Pectinacetylesterase Coilin_N PF15862.5 ETO33483.1 - 2.2e-05 24.3 3.8 2.2e-05 24.3 3.8 2.4 1 1 1 2 2 2 1 Coilin N-terminus RR_TM4-6 PF06459.12 ETO33483.1 - 0.063 13.1 20.3 0.079 12.8 20.3 1.3 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Hid1 PF12722.7 ETO33483.1 - 0.21 9.7 14.1 0.21 9.7 14.1 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein SID-1_RNA_chan PF13965.6 ETO33483.1 - 0.31 9.4 7.3 0.34 9.3 7.3 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MMR1 PF08505.10 ETO33483.1 - 0.45 10.8 21.7 0.59 10.4 21.7 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein AAA_11 PF13086.6 ETO33483.1 - 1.5 8.5 16.7 2.2 8.0 16.7 1.4 1 0 0 1 1 1 0 AAA domain ALMT PF11744.8 ETO33483.1 - 1.7 7.4 18.6 2 7.2 18.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Activator_LAG-3 PF11498.8 ETO33483.1 - 1.9 7.3 28.3 2.4 7.1 28.3 1.1 1 0 0 1 1 1 0 Transcriptional activator LAG-3 MAJIN PF15077.6 ETO33483.1 - 2 8.1 14.4 2.7 7.7 14.4 1.2 1 0 0 1 1 1 0 Membrane-anchored junction protein SLC12 PF03522.15 ETO33483.1 - 3.8 6.4 24.4 4.7 6.1 24.4 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Neur_chan_memb PF02932.16 ETO33483.1 - 4 7.4 11.9 5.6 7.0 11.9 1.4 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Cellulose_synt PF03552.14 ETO33483.1 - 5.1 5.5 8.3 5.7 5.3 8.3 1.2 1 0 0 1 1 1 0 Cellulose synthase CobT PF06213.12 ETO33483.1 - 5.8 6.2 29.7 9.1 5.6 29.7 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT CAF-1_p150 PF11600.8 ETO33483.1 - 6.2 6.5 38.5 9.4 5.9 38.5 1.2 1 0 0 1 1 1 0 Chromatin assembly factor 1 complex p150 subunit, N-terminal LicD PF04991.13 ETO33483.1 - 7.5 6.6 22.5 19 5.3 22.4 1.7 1 1 0 1 1 1 0 LicD family WD40 PF00400.32 ETO33484.1 - 1.1e-53 178.0 24.2 8e-09 36.0 0.1 8.1 8 0 0 8 8 8 8 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO33484.1 - 2.1e-08 33.5 0.1 0.93 8.4 0.0 5.8 2 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO33484.1 - 6.9e-08 32.7 2.0 3.1 8.2 0.0 5.8 1 1 6 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33484.1 - 5.6e-06 25.3 11.0 0.078 11.6 0.0 5.9 2 2 2 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33484.1 - 3.9e-05 23.1 3.1 0.53 9.6 0.0 3.4 2 1 2 4 4 4 3 WD40-like domain PD40 PF07676.12 ETO33484.1 - 0.0014 18.5 4.4 6.7 6.8 0.1 4.4 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat DUF1652 PF07865.11 ETO33484.1 - 0.0039 17.0 0.1 9.4 6.1 0.0 3.8 4 1 1 5 5 5 2 Protein of unknown function (DUF1652) Mid2 PF04478.12 ETO33484.1 - 0.062 13.1 0.0 6.9 6.5 0.0 2.6 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor PQQ_2 PF13360.6 ETO33484.1 - 0.11 12.0 0.0 6.9 6.2 0.0 2.4 1 1 1 2 2 2 0 PQQ-like domain RabGAP-TBC PF00566.18 ETO33484.1 - 0.23 11.1 1.3 28 4.3 0.0 3.9 5 0 0 5 5 5 0 Rab-GTPase-TBC domain DUF4999 PF16390.5 ETO33484.1 - 0.33 11.2 7.6 5.1 7.4 0.1 4.6 4 1 1 5 5 5 0 Domain of unknown function WD40 PF00400.32 ETO33485.1 - 5.2e-28 96.7 3.3 3e-07 31.0 0.3 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat Pentapeptide PF00805.22 ETO33485.1 - 4.7e-09 35.7 3.0 8.6e-09 34.9 3.0 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) ANAPC4_WD40 PF12894.7 ETO33485.1 - 8.2e-09 35.6 0.7 0.0052 17.0 0.0 3.6 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33485.1 - 3.1e-06 26.4 0.5 0.14 11.1 0.0 3.5 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide_4 PF13599.6 ETO33485.1 - 0.00018 21.6 0.1 0.0005 20.2 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO33485.1 - 0.00036 20.6 0.7 0.00077 19.6 0.7 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) WD40_like PF17005.5 ETO33485.1 - 0.015 14.6 3.4 0.26 10.6 0.0 2.8 3 0 0 3 3 3 0 WD40-like domain CUE PF02845.16 ETO33486.1 - 0.0029 17.3 0.1 0.011 15.4 0.1 2.0 2 0 0 2 2 2 1 CUE domain SR-25 PF10500.9 ETO33486.1 - 1 8.9 13.6 2.1 7.9 13.6 1.4 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein AgrB PF04647.15 ETO33488.1 - 0.037 13.3 6.1 0.062 12.6 6.1 1.5 1 1 0 1 1 1 0 Accessory gene regulator B PBP1_TM PF14812.6 ETO33488.1 - 0.24 11.8 0.8 0.35 11.3 0.1 1.6 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal zf-Sec23_Sec24 PF04810.15 ETO33488.1 - 0.3 11.2 3.3 7.4 6.7 0.4 2.4 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger ZapB PF06005.12 ETO33489.1 - 0.00088 19.7 1.4 0.00088 19.7 1.4 4.2 3 1 1 4 4 4 1 Cell division protein ZapB ADIP PF11559.8 ETO33489.1 - 0.0063 16.6 20.4 0.23 11.5 11.1 3.2 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding TPR_MLP1_2 PF07926.12 ETO33489.1 - 0.027 14.5 11.8 0.092 12.8 11.8 2.0 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein HrpB7 PF09486.10 ETO33489.1 - 0.1 13.0 1.3 0.99 9.8 0.1 2.3 2 0 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) SlyX PF04102.12 ETO33489.1 - 0.96 10.1 4.6 7.5 7.2 0.4 3.4 1 1 1 3 3 3 0 SlyX DUF4164 PF13747.6 ETO33489.1 - 1.1 9.5 6.5 0.28 11.5 2.2 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4164) TMF_TATA_bd PF12325.8 ETO33489.1 - 7.8 6.8 22.5 2.1 8.6 8.5 3.3 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding ING PF12998.7 ETO33489.1 - 7.8 7.1 17.8 0.12 13.0 4.8 3.7 4 0 0 4 4 4 0 Inhibitor of growth proteins N-terminal histone-binding bZIP_1 PF00170.21 ETO33489.1 - 9.3 6.4 20.0 3.8 7.7 0.9 5.0 3 1 1 4 4 4 0 bZIP transcription factor CSN5_C PF18323.1 ETO33491.1 - 0.0072 17.2 1.9 0.0072 17.2 1.9 1.9 2 1 0 2 2 2 1 Cop9 signalosome subunit 5 C-terminal domain DUF5101 PF17031.5 ETO33491.1 - 0.26 11.4 13.1 0.17 12.0 7.7 2.5 1 1 2 3 3 3 0 Domain of unknown function (DUF5101) CC2-LZ PF16516.5 ETO33491.1 - 1.1 9.6 10.5 0.13 12.7 5.4 2.0 2 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator L_protein_N PF15518.6 ETO33492.1 - 0.15 12.0 0.0 0.23 11.3 0.0 1.3 1 0 0 1 1 1 0 L protein N-terminus YfbU PF03887.14 ETO33493.1 - 0.048 13.7 1.1 2 8.4 0.6 2.9 2 1 0 2 2 2 0 YfbU domain SPATA1_C PF15743.5 ETO33493.1 - 0.097 12.7 2.0 0.19 11.8 2.0 1.4 1 0 0 1 1 1 0 Spermatogenesis-associated C-terminus CUE PF02845.16 ETO33494.1 - 0.063 13.0 0.1 0.17 11.6 0.1 1.8 1 0 0 1 1 1 0 CUE domain CW_binding_1 PF01473.20 ETO33494.1 - 0.072 13.5 6.7 0.062 13.6 3.5 2.6 2 0 0 2 2 2 0 Putative cell wall binding repeat PufQ PF05398.11 ETO33496.1 - 0.14 12.3 4.1 4.8 7.4 0.2 2.7 2 0 0 2 2 2 0 PufQ cytochrome subunit DUF3439 PF11921.8 ETO33496.1 - 0.27 11.2 6.0 0.96 9.4 5.4 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF3439) WD40 PF00400.32 ETO33497.1 - 6.8e-33 112.2 28.7 5.8e-08 33.3 0.3 7.5 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33497.1 - 6.8e-10 39.1 1.9 3.8 7.9 0.0 6.6 5 1 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33497.1 - 4.3e-09 35.6 1.7 0.094 11.3 0.0 5.4 3 3 2 6 6 6 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO33497.1 - 0.14 10.9 6.9 2.5 6.8 2.1 3.4 1 1 1 2 2 2 0 Nup133 N terminal like DUF3119 PF11317.8 ETO33498.1 - 0.048 14.0 0.7 0.063 13.6 0.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3119) WD40 PF00400.32 ETO33499.1 - 6e-08 33.2 1.5 2.6 9.0 0.1 6.0 7 0 0 7 7 7 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33499.1 - 9.2e-05 22.7 0.0 0.035 14.4 0.0 3.1 2 1 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4192 PF13830.6 ETO33499.1 - 0.035 14.2 0.2 0.052 13.6 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4192) V-ATPase_G PF03179.15 ETO33499.1 - 2.9 8.4 12.0 0.3 11.6 6.2 2.2 2 0 0 2 2 2 0 Vacuolar (H+)-ATPase G subunit TPR_12 PF13424.6 ETO33500.1 - 7e-24 83.9 6.2 7.8e-08 32.5 0.4 3.7 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33500.1 - 6e-18 63.5 9.3 3e-05 23.7 0.1 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33500.1 - 7.2e-16 57.5 0.5 2.6e-05 24.0 0.0 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33500.1 - 2.6e-14 52.3 26.9 9e-05 22.1 1.8 6.0 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33500.1 - 1e-13 50.3 16.3 0.00019 21.4 0.4 5.5 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33500.1 - 7.2e-11 41.3 21.2 0.012 15.7 0.6 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33500.1 - 0.00059 20.5 4.6 2.8 9.0 0.1 5.0 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33500.1 - 0.013 16.1 5.5 5.8 7.8 0.1 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat MIT PF04212.18 ETO33500.1 - 0.019 15.0 10.4 3.5 7.7 0.2 4.4 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain DUF2225 PF09986.9 ETO33500.1 - 0.027 14.2 12.4 0.57 9.9 1.2 3.3 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_11 PF13414.6 ETO33500.1 - 0.035 13.8 19.7 0.22 11.3 0.3 5.6 5 2 2 7 7 7 0 TPR repeat TPR_17 PF13431.6 ETO33500.1 - 0.051 14.0 4.4 0.15 12.5 0.0 3.6 3 1 1 4 4 4 0 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO33500.1 - 0.054 12.9 0.1 2.2 7.8 0.0 2.8 2 0 0 2 2 2 0 SHNi-TPR DUF4142 PF13628.6 ETO33500.1 - 0.069 13.4 0.2 0.18 12.0 0.2 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4142) TPR_19 PF14559.6 ETO33500.1 - 0.19 12.3 1.3 1.4 9.5 0.1 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat Kelch_1 PF01344.25 ETO33501.1 - 1.2e-08 34.4 3.1 7.6e-06 25.4 0.4 3.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO33501.1 - 6.5e-08 32.2 4.0 1.8e-05 24.5 0.2 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO33501.1 - 1.6e-07 31.2 3.2 2.1e-06 27.6 0.2 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33501.1 - 4.5e-07 29.9 0.5 0.056 13.7 0.2 4.0 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO33501.1 - 1e-06 28.8 1.0 7.3e-06 26.1 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO33501.1 - 6.5e-05 22.8 5.5 0.01 15.8 0.2 4.0 5 0 0 5 5 5 2 Kelch motif DUF2615 PF11027.8 ETO33501.1 - 0.045 13.9 7.9 0.96 9.6 0.2 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF2615) DUF1676 PF07898.13 ETO33501.1 - 0.31 11.1 3.5 0.35 10.9 1.5 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) Orf78 PF06024.12 ETO33501.1 - 9.9 6.5 7.4 8.2 6.8 1.0 2.3 2 0 0 2 2 2 0 Orf78 (ac78) Plasmo_rep PF12135.8 ETO33503.1 - 0.15 11.6 2.8 0.74 9.4 0.3 2.6 1 1 0 2 2 2 0 Plasmodium repeat family Mucin PF01456.17 ETO33503.1 - 0.88 9.6 9.4 0.099 12.6 4.9 1.7 2 0 0 2 2 2 0 Mucin-like glycoprotein GREB1 PF15782.5 ETO33503.1 - 1.5 5.9 14.0 2.2 5.3 14.0 1.2 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SRP-alpha_N PF04086.13 ETO33503.1 - 9.2 6.1 23.3 0.19 11.6 13.2 2.1 2 0 0 2 2 2 0 Signal recognition particle, alpha subunit, N-terminal WD40 PF00400.32 ETO33505.1 - 6.7e-55 181.8 15.5 3.1e-09 37.3 0.1 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33505.1 - 1.9e-18 66.6 0.4 1.7e-05 25.0 0.0 5.1 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33505.1 - 2.9e-15 56.1 0.4 0.018 14.0 0.0 6.0 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33505.1 - 0.00027 19.7 4.6 0.62 8.6 0.0 4.6 3 1 2 5 5 5 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33505.1 - 0.0024 17.3 0.2 1.1 8.5 0.0 3.1 1 1 0 2 2 2 2 WD40-like domain HARP PF07443.13 ETO33505.1 - 0.0025 17.4 0.3 4.4 7.0 0.0 3.4 3 0 0 3 3 3 2 HepA-related protein (HARP) Cytochrom_D1 PF02239.16 ETO33505.1 - 0.051 12.1 2.0 4 5.9 0.1 3.2 3 1 0 4 4 4 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO33505.1 - 5.3 7.1 6.5 2.2 8.3 0.2 3.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Noggin PF05806.12 ETO33506.1 - 0.19 11.6 0.0 0.27 11.1 0.0 1.3 1 0 0 1 1 1 0 Noggin Parvo_coat PF00740.18 ETO33507.1 - 0.048 12.3 1.7 0.05 12.3 1.7 1.0 1 0 0 1 1 1 0 Parvovirus coat protein VP2 DUF3399 PF11879.8 ETO33508.1 - 3.1 8.2 7.4 0.2 12.0 1.8 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3399) Mito_carr PF00153.27 ETO33509.1 - 0.0077 16.1 7.1 1.2 9.1 0.0 3.8 4 2 1 5 5 5 2 Mitochondrial carrier protein N-glycanase_C PF09113.10 ETO33509.1 - 0.02 14.7 0.0 0.035 13.9 0.0 1.5 1 0 0 1 1 1 0 Peptide-N-glycosidase F, C terminal TPR_12 PF13424.6 ETO33511.1 - 6.9e-27 93.6 2.6 1.2e-11 44.8 0.2 2.9 1 1 3 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33511.1 - 1.2e-14 53.4 9.5 2.1e-06 27.3 0.2 3.8 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33511.1 - 1.5e-14 52.9 5.8 1.1e-05 25.1 0.3 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33511.1 - 3.2e-14 51.9 13.4 1.2e-05 25.1 0.5 4.2 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33511.1 - 7e-13 48.0 0.0 0.0002 21.1 0.0 4.4 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33511.1 - 6.5e-11 41.5 0.2 0.001 18.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO33511.1 - 2.3e-06 27.5 3.9 5.3e-06 26.3 1.7 2.4 1 1 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) MIT PF04212.18 ETO33511.1 - 0.00012 22.0 12.0 0.21 11.7 0.0 4.3 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_11 PF13414.6 ETO33511.1 - 0.00023 20.8 8.4 0.079 12.7 0.1 3.7 3 1 1 4 4 4 2 TPR repeat TPR_17 PF13431.6 ETO33511.1 - 0.0015 18.8 2.3 2 9.0 0.2 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33511.1 - 0.0018 19.0 0.0 0.85 10.6 0.0 3.1 2 1 1 3 3 2 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO33511.1 - 0.018 15.7 0.0 9.2 7.0 0.0 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33511.1 - 0.029 15.0 4.2 2.3 9.0 0.2 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO33512.1 - 2.4e-38 129.4 25.4 1.6e-07 31.9 1.2 7.3 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO33512.1 - 5.5e-12 45.1 5.8 2.9e-06 26.2 0.2 4.8 2 2 3 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33512.1 - 3e-11 43.5 3.6 0.017 15.4 0.0 5.5 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO33512.1 - 0.019 14.5 0.5 0.26 10.8 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4221) PALB2_WD40 PF16756.5 ETO33512.1 - 0.024 13.6 2.1 5.3 5.9 0.0 3.6 2 1 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF4979 PF16351.5 ETO33512.1 - 0.026 14.8 1.7 55 3.9 0.1 4.2 1 1 2 4 4 4 0 Domain of unknown function (DUF4979) RhoGAP-FF1 PF16512.5 ETO33513.1 - 0.033 14.9 0.2 0.072 13.8 0.2 1.5 1 0 0 1 1 1 0 p190-A and -B Rho GAPs FF domain DUF5389 PF17364.2 ETO33514.1 - 0.014 15.4 0.1 0.04 14.0 0.1 1.7 1 0 0 1 1 1 0 Family of unknown function (DUF5389) Cid2 PF09774.9 ETO33515.1 - 0.13 12.6 10.0 0.19 12.1 10.0 1.2 1 0 0 1 1 1 0 Caffeine-induced death protein 2 GEMIN8 PF15348.6 ETO33515.1 - 0.25 11.6 9.9 0.35 11.1 9.9 1.2 1 0 0 1 1 1 0 Gemini of Cajal bodies-associated protein 8 FAM176 PF14851.6 ETO33515.1 - 4.4 7.0 9.9 6.5 6.4 9.9 1.2 1 0 0 1 1 1 0 FAM176 family Neur_chan_memb PF02932.16 ETO33515.1 - 8 6.4 5.9 9.5 6.2 5.9 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Sec23_BS PF08033.12 ETO33516.1 - 7e-05 23.5 0.5 0.00021 22.0 0.5 1.8 1 0 0 1 1 1 1 Sec23/Sec24 beta-sandwich domain PDEase_I PF00233.19 ETO33517.1 - 2.2e-71 240.4 2.3 5.6e-71 239.0 0.0 2.5 2 2 0 2 2 2 1 3'5'-cyclic nucleotide phosphodiesterase HD PF01966.22 ETO33517.1 - 0.14 12.4 0.0 0.29 11.3 0.0 1.5 1 0 0 1 1 1 0 HD domain FSA_C PF10479.9 ETO33517.1 - 0.78 7.8 7.8 1.4 6.9 7.8 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus DUF5305 PF17231.2 ETO33517.1 - 1.6 8.1 8.6 3.3 7.0 8.6 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5305) WD40 PF00400.32 ETO33521.1 - 4e-91 296.5 57.7 1.3e-07 32.1 0.0 15.3 16 0 0 16 16 15 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33521.1 - 1.7e-21 76.3 14.2 0.037 14.3 0.1 9.6 2 2 7 10 10 10 6 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO33521.1 - 1.8e-09 37.8 0.0 3.9e-09 36.6 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO33521.1 - 2.6e-06 27.0 1.6 5.2e-06 26.0 1.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO33521.1 - 0.0011 19.1 0.2 0.0034 17.5 0.2 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO33521.1 - 0.0013 19.3 0.0 0.02 15.5 0.0 2.9 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO33521.1 - 0.0086 16.4 0.0 0.037 14.3 0.0 2.1 1 0 0 1 1 1 1 AAA domain Nbas_N PF15492.6 ETO33521.1 - 0.019 14.3 12.2 2.8 7.2 0.1 6.2 2 2 4 7 7 7 0 Neuroblastoma-amplified sequence, N terminal Ubiquitin_3 PF14836.6 ETO33521.1 - 0.023 14.6 2.1 3.2 7.8 0.0 5.3 5 1 0 5 5 4 0 Ubiquitin-like domain Pentapeptide_3 PF13576.6 ETO33521.1 - 0.03 14.5 0.6 0.066 13.4 0.6 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) ABC_tran PF00005.27 ETO33521.1 - 0.088 13.3 0.1 0.38 11.3 0.1 2.2 1 0 0 1 1 1 0 ABC transporter RNA_helicase PF00910.22 ETO33521.1 - 0.11 12.8 1.9 0.96 9.9 0.0 3.6 3 1 0 3 3 3 0 RNA helicase PD40 PF07676.12 ETO33521.1 - 1.4 8.9 11.5 14 5.8 0.0 6.0 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat DUF3475 PF11961.8 ETO33521.1 - 7.2 6.8 8.4 51 4.1 0.1 5.0 6 0 0 6 6 6 0 Domain of unknown function (DUF3475) Mannosyl_trans3 PF11051.8 ETO33522.1 - 2.6e-13 49.9 0.4 2.6e-13 49.9 0.4 2.2 2 1 0 2 2 2 1 Mannosyltransferase putative NACHT PF05729.12 ETO33523.1 - 5.7e-07 29.6 0.0 9.5e-07 28.9 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO33523.1 - 0.0017 17.6 1.2 0.013 14.7 0.0 2.1 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 ETO33523.1 - 0.0077 16.6 0.0 0.02 15.3 0.0 1.6 2 0 0 2 2 2 1 AAA ATPase domain Aspzincin_M35 PF14521.6 ETO33523.1 - 0.021 15.4 0.1 0.035 14.7 0.1 1.4 1 0 0 1 1 1 0 Lysine-specific metallo-endopeptidase SMBP PF16785.5 ETO33523.1 - 0.033 14.4 2.6 0.058 13.6 2.6 1.3 1 0 0 1 1 1 0 Small metal-binding protein MDM10 PF12519.8 ETO33523.1 - 1 8.2 8.5 5.1 5.9 0.0 2.1 2 0 0 2 2 2 0 Mitochondrial distribution and morphology protein 10 Z1 PF10593.9 ETO33523.1 - 1.6 8.2 11.2 5.6 6.4 11.2 1.9 1 1 0 1 1 1 0 Z1 domain ELMO_CED12 PF04727.13 ETO33526.1 - 1.8e-32 112.9 0.6 3.1e-32 112.1 0.1 1.7 2 0 0 2 2 2 1 ELMO/CED-12 family Piwi PF02171.17 ETO33529.1 - 5.1e-17 62.1 0.0 8.8e-17 61.3 0.0 1.3 1 0 0 1 1 1 1 Piwi domain DDHD PF02862.17 ETO33529.1 - 0.013 15.7 4.7 0.025 14.7 4.7 1.4 1 0 0 1 1 1 0 DDHD domain AAR2 PF05282.11 ETO33529.1 - 0.054 12.9 4.3 0.073 12.5 4.3 1.2 1 0 0 1 1 1 0 AAR2 protein RP-C_C PF11800.8 ETO33529.1 - 0.72 9.9 3.7 1.3 9.1 3.7 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region DUF4820 PF16091.5 ETO33529.1 - 1.1 8.6 5.2 2.1 7.7 5.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) FYDLN_acid PF09538.10 ETO33529.1 - 6.7 7.4 14.1 24 5.7 9.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (FYDLN_acid) WD40 PF00400.32 ETO33530.1 - 2.6e-22 78.7 3.1 9.1e-06 26.3 0.8 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33530.1 - 0.00032 20.9 0.1 0.00085 19.6 0.1 1.9 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain PRESAN PF09687.10 ETO33530.1 - 0.047 14.3 0.1 0.079 13.5 0.1 1.3 1 0 0 1 1 1 0 Plasmodium RESA N-terminal CNDH2_C PF16858.5 ETO33531.1 - 0.0047 16.8 9.6 0.0061 16.5 9.6 1.1 1 0 0 1 1 1 1 Condensin II complex subunit CAP-H2 or CNDH2, C-term BORCS6 PF10157.9 ETO33531.1 - 0.059 13.6 5.1 0.079 13.2 5.1 1.3 1 1 0 1 1 1 0 BLOC-1-related complex sub-unit 6 DUF2457 PF10446.9 ETO33531.1 - 2.3 7.3 16.3 3.6 6.6 16.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) CENP-B_dimeris PF09026.10 ETO33531.1 - 8.6 6.8 17.4 0.81 10.1 13.0 1.6 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Zip PF02535.22 ETO33532.1 - 0.13 11.5 4.9 0.24 10.6 4.9 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter GCN5L1 PF06320.13 ETO33533.1 - 1.8e-28 99.0 7.0 2.5e-28 98.5 7.0 1.2 1 0 0 1 1 1 1 GCN5-like protein 1 (GCN5L1) FAA_hydrolase_N PF09298.11 ETO33533.1 - 0.037 14.2 2.9 0.067 13.4 2.9 1.6 1 1 0 1 1 1 0 Fumarylacetoacetase N-terminal OmpH PF03938.14 ETO33533.1 - 0.046 14.1 12.8 0.36 11.2 4.6 2.1 2 0 0 2 2 2 0 Outer membrane protein (OmpH-like) Pro_3_hydrox_C PF05373.11 ETO33533.1 - 0.077 13.1 0.3 0.77 9.9 0.3 2.2 1 1 0 1 1 1 0 L-proline 3-hydroxylase, C-terminal TFR_dimer PF04253.15 ETO33533.1 - 0.16 12.1 3.2 0.35 11.0 0.8 2.1 2 1 0 2 2 2 0 Transferrin receptor-like dimerisation domain Spc7 PF08317.11 ETO33533.1 - 0.18 10.7 12.6 0.22 10.4 12.6 1.0 1 0 0 1 1 1 0 Spc7 kinetochore protein PAPS_reduct PF01507.19 ETO33533.1 - 0.19 11.7 2.0 0.15 12.1 0.6 1.5 1 1 1 2 2 2 0 Phosphoadenosine phosphosulfate reductase family DUF4953 PF16313.5 ETO33533.1 - 0.26 10.5 4.2 0.32 10.2 4.2 1.1 1 0 0 1 1 1 0 Met-zincin Seryl_tRNA_N PF02403.22 ETO33533.1 - 0.96 9.7 8.4 3 8.1 2.3 2.2 2 0 0 2 2 2 0 Seryl-tRNA synthetase N-terminal domain NPV_P10 PF05531.12 ETO33533.1 - 1.2 9.7 5.7 1.3 9.5 1.8 2.6 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein CREPT PF16566.5 ETO33533.1 - 1.6 8.9 8.2 2.8 8.1 1.1 2.4 1 1 2 3 3 3 0 Cell-cycle alteration and expression-elevated protein in tumour DUF948 PF06103.11 ETO33533.1 - 2.3 8.5 6.0 9.6 6.5 2.7 2.3 1 1 1 2 2 2 0 Bacterial protein of unknown function (DUF948) Prefoldin PF02996.17 ETO33533.1 - 6.3 6.7 13.9 1.4 8.9 0.7 3.0 2 1 1 3 3 3 0 Prefoldin subunit UQ_con PF00179.26 ETO33534.1 - 6.1e-49 165.3 0.0 7.7e-49 164.9 0.0 1.1 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO33534.1 - 5.2e-07 29.4 0.0 9e-07 28.7 0.0 1.5 1 1 0 1 1 1 1 Prokaryotic E2 family B RGS-like PF09128.11 ETO33534.1 - 0.0043 16.8 0.8 1.5 8.5 0.1 2.1 2 0 0 2 2 2 2 Regulator of G protein signalling-like domain UEV PF05743.13 ETO33534.1 - 0.019 14.8 0.0 0.032 14.1 0.0 1.4 1 0 0 1 1 1 0 UEV domain RWD PF05773.22 ETO33534.1 - 0.056 13.7 0.0 0.12 12.6 0.0 1.6 2 0 0 2 2 2 0 RWD domain Di19_C PF14571.6 ETO33534.1 - 0.072 13.6 0.1 0.11 13.0 0.1 1.3 1 0 0 1 1 1 0 Stress-induced protein Di19, C-terminal Exo_endo_phos PF03372.23 ETO33535.1 - 0.00095 18.7 0.0 0.0015 18.1 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Ras PF00071.22 ETO33537.1 - 0.02 14.5 0.2 0.032 13.8 0.2 1.3 1 0 0 1 1 1 0 Ras family LRIF1 PF15741.5 ETO33537.1 - 0.023 13.3 1.2 0.031 12.8 1.2 1.1 1 0 0 1 1 1 0 Ligand-dependent nuclear receptor-interacting factor 1 Peptidase_S9 PF00326.21 ETO33540.1 - 0.00013 21.5 0.1 0.00021 20.8 0.1 1.2 1 0 0 1 1 1 1 Prolyl oligopeptidase family DUF202 PF02656.15 ETO33541.1 - 1.3e-08 35.2 2.1 1.3e-08 35.2 2.1 1.7 2 0 0 2 2 2 1 Domain of unknown function (DUF202) VTC PF09359.10 ETO33541.1 - 0.001 18.5 0.0 0.0017 17.8 0.0 1.4 1 0 0 1 1 1 1 VTC domain DUF2628 PF10947.8 ETO33541.1 - 0.12 12.7 4.0 0.18 12.2 4.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2628) WD40 PF00400.32 ETO33542.1 - 1.1e-41 140.0 18.6 4.5e-07 30.4 0.0 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33542.1 - 1.8e-15 57.0 0.7 0.00035 20.8 0.0 5.8 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO33542.1 - 2.3e-12 47.2 0.6 0.0048 16.8 0.1 3.3 1 1 1 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO33542.1 - 3.3e-10 39.5 0.8 0.27 10.1 0.0 5.4 1 1 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33542.1 - 1e-05 24.4 12.5 0.085 11.5 0.1 4.7 2 2 3 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO33542.1 - 1.1e-05 24.1 0.1 0.04 12.4 0.1 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO33542.1 - 4.3e-05 23.3 3.4 2.7 8.0 0.0 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Me-amine-dh_H PF06433.11 ETO33542.1 - 0.0023 16.9 0.0 0.3 9.9 0.0 2.6 2 1 1 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) BBS2_Mid PF14783.6 ETO33542.1 - 0.0041 17.1 1.1 2.9 8.0 0.0 4.3 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 ETO33542.1 - 0.0087 15.4 0.7 6.7 6.0 0.1 3.8 2 2 1 4 4 4 1 Neuroblastoma-amplified sequence, N terminal VEFS-Box PF09733.9 ETO33542.1 - 0.034 14.0 0.1 3.2 7.5 0.0 2.7 2 0 0 2 2 2 0 VEFS-Box of polycomb protein MerR_1 PF13411.6 ETO33542.1 - 0.21 11.7 0.6 11 6.2 0.1 3.6 4 0 0 4 4 4 0 MerR HTH family regulatory protein Proteasome_A_N PF10584.9 ETO33542.1 - 0.29 10.8 3.6 23 4.8 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PALB2_WD40 PF16756.5 ETO33542.1 - 1.2 8.0 7.1 3.9 6.3 0.1 3.8 3 2 1 5 5 5 0 Partner and localizer of BRCA2 WD40 domain WD40 PF00400.32 ETO33545.1 - 1.1e-67 222.3 18.9 2.2e-11 44.1 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33545.1 - 3e-24 85.1 1.1 0.0017 18.6 0.0 6.4 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33545.1 - 2e-15 56.6 0.7 0.017 14.1 0.0 6.4 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33545.1 - 2.8e-09 36.7 6.6 0.002 17.5 0.2 3.9 1 1 4 5 5 5 5 WD40-like domain Cytochrom_D1 PF02239.16 ETO33545.1 - 8.8e-06 24.5 3.5 0.25 9.8 0.0 3.2 1 1 3 4 4 4 4 Cytochrome D1 heme domain PD40 PF07676.12 ETO33545.1 - 2.7e-05 24.0 9.2 3.9 7.5 0.1 6.7 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat SGL PF08450.12 ETO33545.1 - 0.0012 18.5 0.7 0.029 14.0 0.0 2.9 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region Coatomer_WDAD PF04053.14 ETO33545.1 - 0.0012 18.0 8.3 0.0054 15.8 1.0 2.9 2 1 2 4 4 4 1 Coatomer WD associated region DUF4999 PF16390.5 ETO33545.1 - 0.002 18.3 4.8 25 5.2 0.1 4.7 5 0 0 5 5 4 0 Domain of unknown function DUF5449 PF17528.2 ETO33545.1 - 0.011 15.5 2.0 6.1 6.6 0.0 4.1 1 1 3 4 4 4 0 Family of unknown function (DUF5449) SBD PF17882.1 ETO33545.1 - 0.017 15.0 0.7 5.1 7.0 0.0 3.9 1 1 3 4 4 4 0 OAA-family lectin sugar binding domain DUF4221 PF13970.6 ETO33545.1 - 0.02 14.4 1.5 0.35 10.4 0.1 3.1 1 1 2 4 4 4 0 Domain of unknown function (DUF4221) PQQ PF01011.21 ETO33545.1 - 0.024 14.6 0.0 27 4.9 0.0 3.6 3 0 0 3 3 3 0 PQQ enzyme repeat NHL PF01436.21 ETO33545.1 - 0.064 13.3 0.2 61 3.9 0.0 3.7 3 0 0 3 3 3 0 NHL repeat TraK PF06586.11 ETO33545.1 - 0.22 11.2 0.7 4.9 6.8 0.0 2.7 2 1 1 3 3 3 0 TraK protein Rota_NS6 PF04866.12 ETO33546.1 - 0.0057 16.9 0.3 0.046 13.9 0.1 2.6 2 0 0 2 2 2 1 Rotavirus non-structural protein 6 DUF2833 PF11090.8 ETO33547.1 - 0.034 14.5 0.2 0.076 13.4 0.2 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2833) Urocanase PF01175.18 ETO33548.1 - 0.031 13.9 0.1 0.042 13.5 0.1 1.1 1 0 0 1 1 1 0 Urocanase Rossmann-like domain G-gamma PF00631.22 ETO33548.1 - 0.1 12.6 0.1 0.19 11.8 0.1 1.4 1 0 0 1 1 1 0 GGL domain Peptidase_M1_N PF17900.1 ETO33549.1 - 1.6e-36 126.2 0.3 1.3e-35 123.3 0.3 2.0 1 1 0 1 1 1 1 Peptidase M1 N-terminal domain Coilin_N PF15862.5 ETO33550.1 - 1.6e-05 24.7 0.0 4.2e-05 23.4 0.0 1.8 1 1 0 1 1 1 1 Coilin N-terminus Peroxin-13_N PF04088.13 ETO33550.1 - 0.0085 16.4 2.6 0.0089 16.3 0.6 2.1 2 0 0 2 2 2 1 Peroxin 13, N-terminal region Striatin PF08232.12 ETO33550.1 - 0.49 11.0 13.9 2.4 8.7 8.7 2.3 2 0 0 2 2 2 0 Striatin family RNA_pol_Rpc4 PF05132.14 ETO33550.1 - 0.83 10.1 10.3 0.29 11.6 5.2 2.1 2 0 0 2 2 2 0 RNA polymerase III RPC4 CCDC106 PF15794.5 ETO33550.1 - 0.94 9.1 15.6 0.12 12.1 9.0 2.1 2 0 0 2 2 2 0 Coiled-coil domain-containing protein 106 Gti1_Pac2 PF09729.9 ETO33550.1 - 1.3 9.1 12.7 0.21 11.6 5.1 2.1 2 0 0 2 2 2 0 Gti1/Pac2 family Eapp_C PF10238.9 ETO33550.1 - 3.3 7.8 12.8 21 5.2 8.1 2.6 2 1 0 2 2 2 0 E2F-associated phosphoprotein RP-C_C PF11800.8 ETO33550.1 - 4 7.5 6.8 8.6 6.4 6.8 1.5 1 0 0 1 1 1 0 Replication protein C C-terminal region MMU163 PF17119.5 ETO33550.1 - 6.2 5.9 8.5 16 4.6 8.5 1.6 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis NST1 PF13945.6 ETO33550.1 - 9.4 6.3 30.1 0.64 10.1 21.4 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator Ax_dynein_light PF10211.9 ETO33552.1 - 1.4e-08 34.9 11.9 1.9e-08 34.5 11.9 1.1 1 0 0 1 1 1 1 Axonemal dynein light chain AAA_11 PF13086.6 ETO33552.1 - 0.0035 17.2 5.2 0.004 17.0 5.2 1.1 1 0 0 1 1 1 1 AAA domain DUF4320 PF14208.6 ETO33552.1 - 0.099 12.7 3.7 1.5 8.9 0.4 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4320) RasGAP_C PF03836.15 ETO33552.1 - 1.9 8.6 13.1 4 7.6 0.4 2.9 1 1 1 2 2 2 0 RasGAP C-terminus Mit_KHE1 PF10173.9 ETO33552.1 - 3.4 7.7 6.8 3.2 7.8 5.4 1.7 1 1 0 1 1 1 0 Mitochondrial K+-H+ exchange-related OxoGdeHyase_C PF16870.5 ETO33553.1 - 1.4e-45 154.7 0.0 1.6e-45 154.5 0.0 1.0 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal Peptidase_C97 PF05903.14 ETO33555.1 - 5.4e-15 55.5 0.5 7.7e-15 55.0 0.5 1.2 1 0 0 1 1 1 1 PPPDE putative peptidase domain DUF778 PF05608.12 ETO33555.1 - 0.031 14.7 0.4 0.05 14.0 0.2 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF778) LRAT PF04970.13 ETO33555.1 - 0.11 12.8 0.6 0.53 10.6 0.1 2.2 2 1 1 3 3 3 0 Lecithin retinol acyltransferase TPR_12 PF13424.6 ETO33557.1 - 4.9e-32 110.1 0.1 1.3e-14 54.2 0.0 3.2 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33557.1 - 2.5e-26 90.3 16.6 8.9e-08 31.6 1.4 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33557.1 - 1.1e-21 76.0 0.0 1.8e-05 24.4 0.0 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33557.1 - 1.6e-20 71.5 9.9 2.2e-06 27.3 0.7 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33557.1 - 3e-20 70.7 0.4 0.00015 21.6 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33557.1 - 6.5e-18 63.4 18.6 1.9e-06 27.6 1.2 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33557.1 - 1.6e-07 31.5 6.0 0.011 16.3 0.2 4.5 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33557.1 - 3.5e-06 26.6 15.3 0.11 12.2 0.3 5.4 4 1 1 5 5 5 3 TPR repeat TPR_17 PF13431.6 ETO33557.1 - 1.7e-05 24.9 2.0 7 7.3 0.0 4.8 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33557.1 - 0.0011 19.6 0.0 18 6.5 0.0 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO33557.1 - 0.0012 18.9 6.4 0.48 10.5 0.0 3.4 3 0 0 3 3 3 2 Fis1 C-terminal tetratricopeptide repeat TPR_16 PF13432.6 ETO33557.1 - 0.0012 19.4 0.2 10 6.8 0.0 3.6 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO33557.1 - 0.0024 18.3 0.1 0.9 10.1 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO33557.1 - 0.0056 16.5 6.4 0.18 11.6 0.3 3.2 2 2 1 3 3 3 2 Domain of unknown function (DUF5113) SPO22 PF08631.10 ETO33557.1 - 0.012 15.2 4.5 0.16 11.4 0.2 3.2 3 1 0 4 4 4 0 Meiosis protein SPO22/ZIP4 like ANAPC3 PF12895.7 ETO33557.1 - 0.034 14.3 5.5 1.4 9.2 0.3 3.4 2 2 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 Coiled-coil_56 PF09813.9 ETO33557.1 - 0.035 14.2 0.1 0.089 12.8 0.1 1.6 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 56 MIT PF04212.18 ETO33557.1 - 0.12 12.5 4.3 9.2 6.4 0.1 3.6 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain PPR PF01535.20 ETO33557.1 - 0.16 12.3 1.7 3.9 7.9 0.1 3.3 3 0 0 3 3 3 0 PPR repeat Sel1 PF08238.12 ETO33557.1 - 0.73 10.6 4.6 0.81 10.5 0.1 3.0 3 0 0 3 3 2 0 Sel1 repeat Spuma_A9PTase PF03539.14 ETO33559.1 - 0.0082 16.3 0.9 0.016 15.4 0.9 1.5 1 0 0 1 1 1 1 Spumavirus aspartic protease (A9) Kelch_1 PF01344.25 ETO33560.1 - 4e-05 23.1 0.1 0.00037 20.0 0.1 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO33560.1 - 0.00016 21.5 1.9 0.072 13.1 0.2 3.9 4 1 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO33560.1 - 0.00019 21.4 3.6 0.0009 19.2 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33560.1 - 0.00048 20.3 0.3 1.8 9.0 0.1 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO33560.1 - 0.0016 18.4 0.9 0.47 10.5 0.4 4.1 5 0 0 5 5 5 1 Kelch motif PUB PF09409.10 ETO33561.1 - 0.011 15.7 0.0 0.035 14.0 0.0 1.8 1 0 0 1 1 1 0 PUB domain NOA36 PF06524.12 ETO33561.1 - 1.1 8.5 8.7 2.2 7.5 8.7 1.4 1 0 0 1 1 1 0 NOA36 protein bZIP_C PF12498.8 ETO33563.1 - 0.053 14.5 0.8 2.5 9.1 0.0 2.4 2 0 0 2 2 2 0 Basic leucine-zipper C terminal BUD22 PF09073.10 ETO33563.1 - 0.41 9.9 7.2 0.69 9.2 7.2 1.3 1 0 0 1 1 1 0 BUD22 MCM6_C PF18263.1 ETO33563.1 - 5.8 7.2 11.5 0.64 10.3 4.3 2.3 2 0 0 2 2 2 0 MCM6 C-terminal winged-helix domain CLASP_N PF12348.8 ETO33565.1 - 0.00014 21.5 0.2 0.00019 21.0 0.2 1.3 1 0 0 1 1 1 1 CLASP N terminal Adaptin_N PF01602.20 ETO33565.1 - 0.011 14.4 0.2 0.018 13.6 0.1 1.3 1 1 0 1 1 1 0 Adaptin N terminal region APG17 PF04108.12 ETO33565.1 - 0.02 14.0 0.2 0.023 13.8 0.2 1.0 1 0 0 1 1 1 0 Autophagy protein Apg17 TPR_12 PF13424.6 ETO33566.1 - 3.5e-32 110.5 1.4 3.5e-11 43.2 0.0 4.3 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33566.1 - 4.7e-23 79.5 6.4 0.00015 21.6 0.0 5.5 5 0 0 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33566.1 - 6e-22 76.5 25.3 6e-06 25.8 1.0 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33566.1 - 1.8e-20 71.4 29.5 0.0005 20.1 0.6 6.9 6 1 0 6 6 6 6 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33566.1 - 2.8e-18 64.5 22.0 0.00069 19.5 0.0 6.5 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33566.1 - 1.1e-17 63.2 0.2 0.013 15.3 0.0 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33566.1 - 1.2e-09 38.2 7.9 0.34 11.6 0.0 6.1 6 0 0 6 6 6 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33566.1 - 8.8e-05 23.0 0.0 1.7 9.7 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat MIT PF04212.18 ETO33566.1 - 0.00089 19.3 5.6 1.1 9.4 0.1 4.4 3 1 1 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 ETO33566.1 - 0.0045 17.6 0.2 12 6.6 0.0 4.3 5 0 0 5 5 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO33566.1 - 0.098 12.9 11.3 0.12 12.7 2.3 3.6 3 1 0 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 DiSB-ORF2_chro PF16506.5 ETO33566.1 - 0.17 11.9 1.0 0.4 10.7 0.1 2.1 2 0 0 2 2 2 0 Putative virion glycoprotein of insect viruses Fis1_TPR_C PF14853.6 ETO33566.1 - 0.33 11.1 0.1 0.33 11.1 0.1 3.7 4 0 0 4 4 4 0 Fis1 C-terminal tetratricopeptide repeat SPO22 PF08631.10 ETO33566.1 - 2.1 7.8 7.4 1.1 8.6 1.4 2.7 2 1 0 2 2 2 0 Meiosis protein SPO22/ZIP4 like WD40 PF00400.32 ETO33568.1 - 2.6e-10 40.7 5.6 6.4e-09 36.3 0.3 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat 2OG-FeII_Oxy_2 PF13532.6 ETO33570.1 - 1.7e-26 93.6 0.0 1.3e-24 87.5 0.0 2.4 1 1 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily DUF5530 PF17670.1 ETO33570.1 - 0.31 10.8 3.8 2.8 7.7 3.4 2.5 1 1 0 1 1 1 0 Family of unknown function (DUF5530) DUF3522 PF12036.8 ETO33571.1 - 1.1e-43 149.8 5.2 1.3e-43 149.5 5.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3522) Ceramidase PF05875.12 ETO33571.1 - 0.026 13.9 11.2 0.79 9.1 9.9 2.1 1 1 1 2 2 2 0 Ceramidase alpha-hel2 PF14456.6 ETO33572.1 - 0.00064 19.1 1.0 0.00079 18.8 1.0 1.1 1 0 0 1 1 1 1 Alpha-helical domain 2 Radical_SAM_N PF08497.10 ETO33572.1 - 7.3 5.7 7.2 5.5 6.1 6.0 1.4 1 1 0 1 1 1 0 Radical SAM N-terminal GvpK PF05121.12 ETO33576.1 - 0.0074 16.3 0.4 0.0074 16.3 0.4 1.8 2 1 0 2 2 2 1 Gas vesicle protein K Gp-FAR-1 PF05823.12 ETO33576.1 - 0.0081 16.5 4.5 0.013 15.8 4.5 1.3 1 0 0 1 1 1 1 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Clathrin_lg_ch PF01086.17 ETO33576.1 - 0.039 14.0 10.6 0.05 13.6 10.6 1.3 1 0 0 1 1 1 0 Clathrin light chain DUF4758 PF15950.5 ETO33576.1 - 0.067 13.5 0.9 0.087 13.2 0.9 1.2 1 0 0 1 1 1 0 Putative sperm flagellar membrane protein TSC22 PF01166.18 ETO33576.1 - 0.072 13.4 0.3 0.072 13.4 0.3 2.5 2 1 1 3 3 3 0 TSC-22/dip/bun family DUF5300 PF17224.3 ETO33576.1 - 0.073 13.3 1.0 0.1 12.9 0.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF5300) ING PF12998.7 ETO33576.1 - 0.31 11.7 11.0 0.038 14.6 4.7 2.3 1 1 2 3 3 3 0 Inhibitor of growth proteins N-terminal histone-binding RNase_H2-Ydr279 PF09468.10 ETO33576.1 - 0.69 10.1 8.5 1.4 9.1 8.5 1.5 1 1 0 1 1 1 0 Ydr279p protein family (RNase H2 complex component) wHTH domain Glyco_hydro_4C PF11975.8 ETO33576.1 - 1.1 9.2 4.9 1.3 9.1 4.9 1.1 1 0 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain GrpE PF01025.19 ETO33576.1 - 1.3 8.7 13.1 3 7.5 13.0 1.5 1 1 0 1 1 1 0 GrpE FapA PF03961.13 ETO33576.1 - 1.6 7.3 12.1 1.8 7.1 12.1 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A DIT1_PvcA PF05141.12 ETO33576.1 - 1.8 7.9 10.6 10 5.5 10.6 1.8 1 1 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein K-box PF01486.17 ETO33577.1 - 0.007 16.5 0.6 0.44 10.7 0.1 2.4 2 0 0 2 2 2 2 K-box region PGP_phosphatase PF09419.10 ETO33577.1 - 0.13 11.9 2.2 0.12 11.9 0.8 1.7 1 1 1 2 2 2 0 Mitochondrial PGP phosphatase PT PF04886.12 ETO33578.1 - 4.4e-21 74.1 147.8 2.4 7.8 21.4 8.3 1 1 3 4 4 4 2 PT repeat TSP_1 PF00090.19 ETO33578.1 - 5.4e-06 26.5 10.6 1.6e-05 25.1 10.6 1.9 1 0 0 1 1 1 1 Thrombospondin type 1 domain Folliculin PF11704.8 ETO33579.1 - 0.86 9.5 8.0 1.2 9.0 8.0 1.3 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport PI3K_1B_p101 PF10486.9 ETO33579.1 - 1 7.1 12.9 1.2 6.8 12.9 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Roughex PF06020.11 ETO33579.1 - 1.4 7.9 10.4 1.6 7.7 10.4 1.1 1 0 0 1 1 1 0 Drosophila roughex protein CAC1F_C PF16885.5 ETO33579.1 - 1.9 8.1 9.3 2.3 7.8 9.3 1.0 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Med26_C PF15693.5 ETO33579.1 - 1.9 8.6 14.1 2.9 8.0 14.1 1.3 1 0 0 1 1 1 0 Mediator complex subunit 26 C-terminal DUF2151 PF10221.9 ETO33579.1 - 5.3 5.5 19.4 6.2 5.3 19.4 1.1 1 0 0 1 1 1 0 Cell cycle and development regulator WD40 PF00400.32 ETO33580.1 - 5.7e-35 118.7 18.7 0.00012 22.8 0.0 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO33580.1 - 5.1e-05 22.4 1.0 0.05 12.6 0.0 4.1 1 1 3 4 4 4 1 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO33580.1 - 0.0007 19.8 2.4 3.3 8.1 0.1 4.7 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Cas1_AcylT PF07779.12 ETO33580.1 - 0.049 12.5 0.1 0.077 11.9 0.1 1.3 1 0 0 1 1 1 0 10 TM Acyl Transferase domain found in Cas1p Myotub-related PF06602.14 ETO33581.1 - 2.5e-63 214.1 2.3 2.5e-63 214.1 2.3 1.6 2 0 0 2 2 2 1 Myotubularin-like phosphatase domain GRAM PF02893.20 ETO33581.1 - 0.032 14.1 0.1 0.08 12.8 0.1 1.7 1 0 0 1 1 1 0 GRAM domain Myotub-related PF06602.14 ETO33582.1 - 8.6e-44 149.9 1.2 1.2e-43 149.4 1.2 1.2 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain 3-PAP PF12578.8 ETO33582.1 - 1.9e-05 24.4 0.3 2.5e-05 24.0 0.3 1.4 1 0 0 1 1 1 1 Myotubularin-associated protein Dynein_heavy PF03028.15 ETO33582.1 - 0.038 14.1 0.1 0.052 13.6 0.1 1.4 1 0 0 1 1 1 0 Dynein heavy chain region D6 P-loop domain LRR_8 PF13855.6 ETO33583.1 - 8.4e-06 25.5 18.0 0.00051 19.7 2.1 4.5 2 2 2 4 4 4 3 Leucine rich repeat LRR_1 PF00560.33 ETO33583.1 - 1.1 10.1 14.6 28 5.8 0.1 6.7 6 0 0 6 6 6 0 Leucine Rich Repeat ABC_ATPase PF09818.9 ETO33584.1 - 1.4e-115 386.7 3.7 1.9e-81 274.2 0.6 2.9 2 1 0 2 2 2 2 Predicted ATPase of the ABC class AAA_23 PF13476.6 ETO33584.1 - 0.0095 16.4 0.4 0.0095 16.4 0.4 3.3 3 1 0 3 3 3 1 AAA domain SOR PF07682.11 ETO33585.1 - 0.053 12.4 1.0 0.086 11.7 1.0 1.2 1 0 0 1 1 1 0 Sulphur oxygenase reductase DUF4275 PF14101.6 ETO33585.1 - 6.9 6.8 12.7 0.09 12.9 4.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4275) gag-asp_proteas PF13975.6 ETO33587.1 - 0.032 14.8 0.0 0.1 13.2 0.0 1.9 2 0 0 2 2 2 0 gag-polyprotein putative aspartyl protease DUF4296 PF14129.6 ETO33588.1 - 0.0062 17.1 4.7 0.0062 17.1 4.7 2.0 2 0 0 2 2 2 1 Domain of unknown function (DUF4296) SOGA PF11365.8 ETO33588.1 - 0.4 11.8 7.3 0.62 11.2 4.8 2.4 1 1 1 2 2 2 0 Protein SOGA FapA PF03961.13 ETO33588.1 - 2.9 6.4 11.5 3.8 6.0 11.5 1.2 1 1 0 1 1 1 0 Flagellar Assembly Protein A Bud13 PF09736.9 ETO33589.1 - 0.028 14.8 3.8 0.035 14.5 3.8 1.3 1 0 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex zf-CCCH PF00642.24 ETO33591.1 - 1.1e-08 34.8 5.3 2.3e-08 33.7 5.3 1.6 1 0 0 1 1 1 1 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf_CCCH_4 PF18345.1 ETO33591.1 - 1.6e-06 28.0 3.9 2.9e-06 27.1 3.9 1.5 1 0 0 1 1 1 1 Zinc finger domain zf-CCCH_4 PF18044.1 ETO33591.1 - 0.0011 18.8 3.6 0.0019 18.0 3.6 1.4 1 0 0 1 1 1 1 CCCH-type zinc finger Torus PF16131.5 ETO33591.1 - 0.7 10.6 6.1 0.96 10.2 4.0 2.5 2 1 0 2 2 2 0 Torus domain WWE PF02825.20 ETO33592.1 - 0.0031 18.1 0.1 0.007 16.9 0.1 1.6 1 1 0 1 1 1 1 WWE domain Ceramidase PF05875.12 ETO33593.1 - 1.4e-31 109.9 23.7 1.8e-31 109.6 23.7 1.1 1 0 0 1 1 1 1 Ceramidase DUF1314 PF07013.11 ETO33594.1 - 0.015 15.2 0.3 0.027 14.3 0.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1314) Claudin_3 PF06653.11 ETO33594.1 - 0.57 10.1 10.9 1.2 9.1 1.4 2.9 3 0 0 3 3 3 0 Tight junction protein, Claudin-like SGP PF17228.2 ETO33594.1 - 2.6 9.0 4.1 22 5.9 0.1 2.8 3 0 0 3 3 3 0 Sulphur globule protein MGC-24 PF05283.11 ETO33595.1 - 2.3 8.7 11.1 3.7 8.0 11.1 1.3 1 1 0 1 1 1 0 Multi-glycosylated core protein 24 (MGC-24), sialomucin NADPH_Ox PF08414.10 ETO33596.1 - 0.013 15.8 2.3 0.017 15.4 2.1 1.4 1 1 0 1 1 1 0 Respiratory burst NADPH oxidase Codanin-1_C PF15296.6 ETO33596.1 - 0.15 12.1 4.7 0.087 12.9 2.7 1.6 1 1 0 1 1 1 0 Codanin-1 C-terminus Mpv17_PMP22 PF04117.12 ETO33598.1 - 1e-15 57.7 1.0 1e-15 57.7 1.0 1.8 2 0 0 2 2 2 1 Mpv17 / PMP22 family DcpS_C PF11969.8 ETO33599.1 - 6.1e-17 62.1 1.5 1.2e-16 61.2 0.3 2.2 2 0 0 2 2 2 1 Scavenger mRNA decapping enzyme C-term binding zf-C2HE PF16278.5 ETO33599.1 - 3.5e-13 49.8 1.3 1.2e-12 48.1 1.3 2.0 1 0 0 1 1 1 1 C2HE / C2H2 / C2HC zinc-binding finger HIT PF01230.23 ETO33599.1 - 1.9e-08 34.9 0.0 4.8e-08 33.6 0.0 1.7 1 0 0 1 1 1 1 HIT domain DUF3276 PF11680.8 ETO33599.1 - 0.0087 16.2 0.9 0.025 14.7 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF3276) DUF726 PF05277.12 ETO33600.1 - 2.5e-90 302.9 10.8 2e-37 128.9 0.1 3.1 3 0 0 3 3 3 3 Protein of unknown function (DUF726) Zip PF02535.22 ETO33600.1 - 0.02 14.1 0.2 0.02 14.1 0.2 4.0 3 1 0 3 3 3 0 ZIP Zinc transporter CMV_1a PF12467.8 ETO33600.1 - 0.027 14.8 3.1 0.036 14.4 0.6 2.2 2 0 0 2 2 2 0 Cucumber mosaic virus 1a protein family CDC45 PF02724.14 ETO33600.1 - 0.24 9.7 50.4 0.14 10.5 19.0 3.2 3 0 0 3 3 3 0 CDC45-like protein SDA1 PF05285.12 ETO33600.1 - 0.61 9.5 74.4 2.1 7.7 25.7 3.1 3 0 0 3 3 3 0 SDA1 SAPS PF04499.15 ETO33600.1 - 1.7 7.3 39.4 0.33 9.7 13.4 3.4 3 0 0 3 3 3 0 SIT4 phosphatase-associated protein Kelch_6 PF13964.6 ETO33601.1 - 1.4e-08 34.7 2.5 2.1e-05 24.7 0.0 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO33601.1 - 2.3e-06 27.1 1.1 6.8e-05 22.4 0.0 3.5 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO33601.1 - 9.6e-06 25.5 1.9 5.7e-05 23.0 0.0 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO33601.1 - 0.00012 22.3 0.2 0.016 15.5 0.0 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO33601.1 - 0.00064 19.6 0.4 0.0086 16.1 0.3 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO33601.1 - 0.11 12.5 1.2 1.7 8.8 0.0 3.4 3 2 0 3 3 3 0 Kelch motif DNA_pol_E_B PF04042.16 ETO33602.1 - 1.3e-21 77.0 1.7 2.4e-21 76.0 1.7 1.5 1 1 0 1 1 1 1 DNA polymerase alpha/epsilon subunit B Pol_alpha_B_N PF08418.10 ETO33602.1 - 0.16 11.9 1.9 0.13 12.2 0.3 1.6 2 0 0 2 2 2 0 DNA polymerase alpha subunit B N-terminal Calpain_III PF01067.22 ETO33603.1 - 0.019 15.2 0.6 0.048 13.9 0.6 1.7 1 1 0 1 1 1 0 Calpain large subunit, domain III WD40 PF00400.32 ETO33604.1 - 4.3e-12 46.3 0.9 2e-05 25.2 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO33604.1 - 0.0026 16.5 0.2 0.39 9.3 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33604.1 - 0.0057 16.9 0.1 0.089 13.1 0.0 2.1 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Marek_SORF3 PF07153.11 ETO33604.1 - 0.066 12.5 0.1 0.17 11.2 0.0 1.6 1 1 1 2 2 2 0 Marek's disease-like virus SORF3 protein BBS2_Mid PF14783.6 ETO33604.1 - 0.081 13.0 0.5 1 9.4 0.3 2.4 1 1 1 2 2 2 0 Ciliary BBSome complex subunit 2, middle region DUF2457 PF10446.9 ETO33605.1 - 0.27 10.3 16.1 0.38 9.9 16.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) DUF2076 PF09849.9 ETO33605.1 - 0.41 10.7 9.5 0.57 10.2 9.5 1.2 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Secretin_N_2 PF07655.13 ETO33605.1 - 0.58 10.7 8.6 1.3 9.6 8.6 1.5 1 0 0 1 1 1 0 Secretin N-terminal domain Copper-bind PF00127.20 ETO33606.1 - 0.036 14.5 0.3 0.12 12.9 0.0 2.0 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family Kelch_5 PF13854.6 ETO33606.1 - 0.066 13.2 0.2 10 6.2 0.0 3.2 3 0 0 3 3 3 0 Kelch motif Colicin_V PF02674.16 ETO33607.1 - 0.0081 16.1 2.5 0.012 15.6 2.5 1.2 1 0 0 1 1 1 1 Colicin V production protein SPRY PF00622.28 ETO33608.1 - 7.6e-06 26.0 0.1 1.2e-05 25.4 0.1 1.3 1 1 0 1 1 1 1 SPRY domain AMP-binding PF00501.28 ETO33609.1 - 6.7e-15 54.6 0.4 8.9e-10 37.7 0.0 2.6 3 0 0 3 3 3 2 AMP-binding enzyme TraS PF10624.9 ETO33609.1 - 0.034 14.1 1.2 0.038 13.9 0.1 1.7 2 0 0 2 2 2 0 Plasmid conjugative transfer entry exclusion protein TraS AMP-binding PF00501.28 ETO33610.1 - 1.7e-11 43.4 0.1 2.4e-11 42.9 0.1 1.1 1 0 0 1 1 1 1 AMP-binding enzyme AMP-binding_C PF13193.6 ETO33610.1 - 0.00015 22.7 0.0 0.00046 21.1 0.0 1.8 2 0 0 2 2 2 1 AMP-binding enzyme C-terminal domain WD40 PF00400.32 ETO33611.1 - 6.5e-87 283.1 37.0 6.7e-11 42.6 0.1 10.8 11 0 0 11 11 11 10 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33611.1 - 6.2e-38 129.0 5.6 0.00045 20.5 0.0 9.7 1 1 9 10 10 10 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33611.1 - 9.9e-24 83.9 3.1 0.00048 19.2 0.0 9.1 1 1 9 10 10 10 7 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO33611.1 - 1.7e-17 64.0 0.4 0.0012 18.8 0.0 5.6 1 1 4 5 5 5 4 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO33611.1 - 2.7e-12 46.3 9.1 0.035 14.0 0.0 8.9 10 0 0 10 10 10 3 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO33611.1 - 6.1e-12 44.8 1.6 0.0045 15.6 0.1 5.2 1 1 6 7 7 7 5 Cytochrome D1 heme domain WD40_like PF17005.5 ETO33611.1 - 2.3e-11 43.6 0.3 0.036 13.4 0.0 5.1 1 1 3 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO33611.1 - 8.4e-09 34.6 16.3 0.31 9.7 0.1 7.1 1 1 5 7 7 7 4 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO33611.1 - 1.2e-08 34.5 1.2 8.7e-05 21.7 0.7 3.3 1 1 1 3 3 3 2 Coatomer WD associated region DUF5570 PF17731.1 ETO33611.1 - 7.3e-07 29.3 13.0 1.7 8.8 0.0 8.1 1 1 8 10 10 10 1 Family of unknown function (DUF5570) Me-amine-dh_H PF06433.11 ETO33611.1 - 3.8e-06 26.0 0.1 0.11 11.4 0.0 3.9 2 1 3 5 5 5 3 Methylamine dehydrogenase heavy chain (MADH) Nucleoporin_N PF08801.11 ETO33611.1 - 1.4e-05 24.0 13.6 0.22 10.2 0.1 5.4 2 2 3 5 5 5 3 Nup133 N terminal like PQQ PF01011.21 ETO33611.1 - 3.1e-05 23.7 0.0 5.3 7.2 0.0 5.6 6 0 0 6 6 6 1 PQQ enzyme repeat VID27 PF08553.10 ETO33611.1 - 0.0027 16.8 0.2 1 8.3 0.0 3.3 1 1 2 4 4 4 1 VID27 C-terminal WD40-like domain Utp8 PF10395.9 ETO33611.1 - 0.0095 14.5 0.2 17 3.7 0.0 3.7 1 1 2 4 4 4 0 Utp8 family HPS6 PF15702.5 ETO33611.1 - 0.011 13.8 0.0 21 2.9 0.0 4.5 2 2 2 5 5 5 0 Hermansky-Pudlak syndrome 6 protein DUF1854 PF08909.11 ETO33611.1 - 0.077 12.8 2.3 6.5 6.6 0.1 4.3 3 2 3 6 6 6 0 Domain of unknown function (DUF1854) Methyltransf_3 PF01596.17 ETO33611.1 - 0.15 11.2 0.0 5.5 6.1 0.0 3.2 2 2 2 4 4 4 0 O-methyltransferase Proteasome_A_N PF10584.9 ETO33611.1 - 2.6 7.8 26.5 11 5.8 0.0 8.1 9 0 0 9 9 8 0 Proteasome subunit A N-terminal signature DUF4999 PF16390.5 ETO33611.1 - 3.3 8.0 4.4 1.4e+02 2.8 0.0 4.2 5 0 0 5 5 4 0 Domain of unknown function WD40 PF00400.32 ETO33612.1 - 2.4e-07 31.3 0.6 7.5e-07 29.8 0.3 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat NACHT PF05729.12 ETO33612.1 - 1.1e-06 28.7 0.0 3.1e-06 27.2 0.0 1.8 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO33612.1 - 9.3e-06 25.2 1.0 2.8e-05 23.6 1.0 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO33612.1 - 0.0014 18.7 0.0 0.0037 17.4 0.0 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO33612.1 - 0.015 15.4 0.4 0.05 13.8 0.4 1.9 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) ABC_tran PF00005.27 ETO33612.1 - 0.018 15.6 0.1 1 9.9 0.0 3.3 2 1 0 2 2 2 0 ABC transporter AAA_18 PF13238.6 ETO33612.1 - 0.021 15.4 0.0 0.13 12.8 0.0 2.5 1 0 0 1 1 1 0 AAA domain ANAPC4_WD40 PF12894.7 ETO33612.1 - 0.026 14.8 0.0 0.11 12.8 0.0 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain AAA_22 PF13401.6 ETO33612.1 - 0.11 12.7 0.6 0.88 9.8 0.0 2.8 3 1 0 3 3 3 0 AAA domain UPF0231 PF06062.11 ETO33612.1 - 8 6.8 15.0 1.7 9.0 0.8 4.6 4 1 1 5 5 5 0 Uncharacterised protein family (UPF0231) SAM_1 PF00536.30 ETO33613.1 - 0.027 14.9 0.0 0.056 13.9 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO33613.1 - 0.1 12.8 0.2 0.26 11.4 0.0 1.7 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) SPRY PF00622.28 ETO33615.1 - 1.2e-26 93.2 0.2 1.2e-26 93.2 0.2 2.1 2 0 0 2 2 2 1 SPRY domain WD40 PF00400.32 ETO33616.1 - 3.2e-06 27.8 1.1 0.0018 19.0 0.4 2.5 2 1 0 2 2 2 2 WD domain, G-beta repeat Ig_6 PF18452.1 ETO33616.1 - 0.085 12.4 0.4 0.16 11.6 0.2 1.5 1 1 0 1 1 1 0 Immunoglobulin domain WD40 PF00400.32 ETO33617.1 - 7.3e-11 42.5 5.5 2.7e-06 28.0 1.3 3.3 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33617.1 - 0.0083 16.4 0.2 5.9 7.3 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33617.1 - 0.014 14.1 0.7 2.1 6.9 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33617.1 - 0.043 13.1 0.1 0.054 12.8 0.1 1.3 1 0 0 1 1 1 0 WD40-like domain zf-RING_2 PF13639.6 ETO33618.1 - 0.036 14.4 2.2 0.13 12.6 1.0 2.4 1 1 1 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO33618.1 - 0.79 9.6 8.3 0.29 11.0 3.4 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO33618.1 - 2.3 8.6 6.1 24 5.3 6.1 2.7 1 1 0 1 1 1 0 RING-like domain WD40 PF00400.32 ETO33619.1 - 1.9e-21 75.9 12.6 2.7e-07 31.2 0.1 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33619.1 - 6.1e-08 32.9 0.7 0.045 14.1 0.0 3.6 3 1 1 4 4 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33619.1 - 2.8e-06 26.9 12.2 0.0011 18.3 0.7 3.5 2 2 1 3 3 3 1 WD40-like domain Nup160 PF11715.8 ETO33619.1 - 5.5e-06 25.3 7.9 0.011 14.4 1.2 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Cast PF10174.9 ETO33619.1 - 0.002 16.5 21.5 0.0025 16.1 21.5 1.1 1 0 0 1 1 1 1 RIM-binding protein of the cytomatrix active zone Lebercilin PF15619.6 ETO33619.1 - 0.0048 16.6 30.0 0.18 11.4 10.0 2.5 2 1 1 3 3 3 2 Ciliary protein causing Leber congenital amaurosis disease DUF4164 PF13747.6 ETO33619.1 - 0.0099 16.1 3.0 0.0099 16.1 3.0 2.7 1 1 0 2 2 2 1 Domain of unknown function (DUF4164) Ax_dynein_light PF10211.9 ETO33619.1 - 0.011 15.8 13.6 0.011 15.8 13.6 3.0 1 1 2 3 3 3 0 Axonemal dynein light chain Fez1 PF06818.15 ETO33619.1 - 0.028 14.9 21.0 0.057 13.9 21.0 1.5 1 0 0 1 1 1 0 Fez1 HalX PF08663.10 ETO33619.1 - 0.11 12.9 3.8 20 5.6 0.6 3.2 1 1 1 3 3 3 0 HalX domain CtIP_N PF10482.9 ETO33619.1 - 0.16 12.0 22.2 0.068 13.2 19.5 1.7 1 1 0 1 1 1 0 Tumour-suppressor protein CtIP N-terminal domain TMF_TATA_bd PF12325.8 ETO33619.1 - 0.18 12.0 22.1 0.12 12.6 5.6 2.4 1 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding ATG16 PF08614.11 ETO33619.1 - 0.26 11.5 21.2 0.027 14.7 14.7 2.1 1 1 1 2 2 2 0 Autophagy protein 16 (ATG16) CALCOCO1 PF07888.11 ETO33619.1 - 0.59 8.9 18.0 0.95 8.2 18.0 1.2 1 0 0 1 1 1 0 Calcium binding and coiled-coil domain (CALCOCO1) like APG6_N PF17675.1 ETO33619.1 - 0.61 10.6 28.9 0.047 14.2 16.2 2.5 2 1 1 3 3 2 0 Apg6 coiled-coil region MAD PF05557.13 ETO33619.1 - 0.62 8.4 25.3 0.82 8.0 25.3 1.1 1 0 0 1 1 1 0 Mitotic checkpoint protein LPP PF04728.13 ETO33619.1 - 0.64 10.5 13.3 9.3 6.7 0.4 4.1 2 1 1 3 3 3 0 Lipoprotein leucine-zipper Cytochrom_B562 PF07361.11 ETO33619.1 - 1 10.0 13.6 0.55 10.9 9.2 2.3 1 1 1 2 2 2 0 Cytochrome b562 DUF1664 PF07889.12 ETO33619.1 - 1.3 9.0 17.7 5.5 7.0 3.2 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) DUF3584 PF12128.8 ETO33619.1 - 1.5 6.3 22.1 1.9 5.9 22.1 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TPR_MLP1_2 PF07926.12 ETO33619.1 - 1.6 8.8 23.7 0.22 11.6 6.6 2.6 1 1 1 2 2 2 0 TPR/MLP1/MLP2-like protein FAM76 PF16046.5 ETO33619.1 - 1.8 7.8 26.3 0.021 14.2 12.2 2.4 1 1 1 2 2 1 0 FAM76 protein Csm1_N PF18504.1 ETO33619.1 - 1.9 8.9 23.3 1.2 9.5 6.7 3.7 1 1 4 5 5 5 0 Csm1 N-terminal domain DUF2203 PF09969.9 ETO33619.1 - 2 9.1 14.0 0.79 10.5 7.5 2.6 2 1 1 3 3 2 0 Uncharacterized conserved protein (DUF2203) Golgin_A5 PF09787.9 ETO33619.1 - 3.1 7.2 24.5 5.9 6.3 24.5 1.4 1 0 0 1 1 1 0 Golgin subfamily A member 5 Tropomyosin_1 PF12718.7 ETO33619.1 - 3.7 7.7 29.4 0.073 13.2 6.5 2.4 1 1 1 2 2 2 0 Tropomyosin like BRE1 PF08647.11 ETO33619.1 - 4 7.6 30.3 0.094 12.8 9.8 2.5 1 1 1 2 2 2 0 BRE1 E3 ubiquitin ligase HsbA PF12296.8 ETO33619.1 - 4.2 7.8 8.5 0.28 11.6 0.4 2.8 4 0 0 4 4 2 0 Hydrophobic surface binding protein A Syntaxin_2 PF14523.6 ETO33619.1 - 4.6 7.7 35.2 7.3 7.0 12.9 3.4 2 1 1 3 3 3 0 Syntaxin-like protein Baculo_PEP_C PF04513.12 ETO33619.1 - 5.4 7.0 19.2 3.9 7.5 15.2 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus CC2-LZ PF16516.5 ETO33619.1 - 6.5 7.2 23.8 0.052 13.9 7.3 2.8 1 1 0 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator LMBR1 PF04791.16 ETO33619.1 - 6.9 5.5 18.3 10 4.9 18.3 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein YabA PF06156.13 ETO33619.1 - 7 7.3 22.9 9.8 6.9 10.8 2.9 1 1 1 2 2 2 0 Initiation control protein YabA DUF4407 PF14362.6 ETO33619.1 - 7 5.9 17.9 26 4.0 17.9 1.8 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Vps51 PF08700.11 ETO33619.1 - 7.2 6.8 18.4 0.54 10.4 1.8 3.8 3 1 0 3 3 3 0 Vps51/Vps67 Jnk-SapK_ap_N PF09744.9 ETO33619.1 - 7.6 6.7 28.1 0.66 10.2 13.0 2.5 2 1 1 3 3 2 0 JNK_SAPK-associated protein-1 CENP-H PF05837.12 ETO33619.1 - 7.7 7.0 27.8 1.2 9.6 7.4 2.3 1 1 1 2 2 2 0 Centromere protein H (CENP-H) HMMR_N PF15905.5 ETO33619.1 - 7.7 5.9 30.0 13 5.2 30.0 1.4 1 0 0 1 1 1 0 Hyaluronan mediated motility receptor N-terminal DUF1515 PF07439.11 ETO33619.1 - 7.9 6.5 7.1 6.5 6.8 0.8 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1515) PRKG1_interact PF15898.5 ETO33619.1 - 9.1 7.2 22.7 3 8.8 6.0 2.7 1 1 1 2 2 2 0 cGMP-dependent protein kinase interacting domain Mis14 PF08641.12 ETO33619.1 - 9.5 6.5 17.7 4.4 7.6 5.2 2.7 2 1 0 2 2 2 0 Kinetochore protein Mis14 like Cation_efflux PF01545.21 ETO33620.1 - 0.00014 21.6 8.5 0.00022 21.0 8.5 1.4 1 1 0 1 1 1 1 Cation efflux family DUF3611 PF12263.8 ETO33620.1 - 0.018 14.9 3.9 0.018 14.9 3.9 1.8 1 1 1 2 2 2 0 Protein of unknown function (DUF3611) DUF202 PF02656.15 ETO33620.1 - 5.6 7.5 6.1 0.77 10.2 0.9 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF202) RRM_1 PF00076.22 ETO33621.1 - 1.4e-19 69.6 0.0 3e-19 68.6 0.0 1.6 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO33621.1 - 0.00082 19.3 0.0 0.0025 17.8 0.0 1.8 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ETO33621.1 - 0.0046 16.8 0.0 0.01 15.7 0.0 1.6 1 1 0 1 1 1 1 Occluded RNA-recognition motif RRM_3 PF08777.11 ETO33621.1 - 0.0054 16.8 0.2 0.11 12.5 0.0 2.2 2 0 0 2 2 2 1 RNA binding motif RRM_7 PF16367.5 ETO33621.1 - 0.0092 16.1 0.0 0.025 14.7 0.0 1.7 1 1 0 1 1 1 1 RNA recognition motif RRM_5 PF13893.6 ETO33621.1 - 0.015 14.9 0.0 0.023 14.3 0.0 1.3 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) MFS_1 PF07690.16 ETO33622.1 - 2.2e-12 46.6 14.4 3.3e-12 46.0 14.4 1.2 1 0 0 1 1 1 1 Major Facilitator Superfamily DUF3481 PF11980.8 ETO33622.1 - 0.017 14.8 0.7 0.046 13.4 0.3 1.9 1 1 0 1 1 1 0 C-terminal domain of neuropilin glycoprotein Pam17 PF08566.10 ETO33622.1 - 0.25 11.2 0.4 0.49 10.2 0.3 1.4 1 1 0 1 1 1 0 Mitochondrial import protein Pam17 DUF3040 PF11239.8 ETO33622.1 - 3.5 8.0 11.0 4.5 7.6 1.4 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) MFS_1_like PF12832.7 ETO33622.1 - 9.1 5.0 20.8 1.4 7.7 13.5 2.1 1 1 1 2 2 2 0 MFS_1 like family CBP_BcsR PF10945.8 ETO33624.1 - 0.17 11.4 0.4 1.7 8.2 0.1 2.3 2 0 0 2 2 2 0 Cellulose biosynthesis protein BcsR CDC45 PF02724.14 ETO33625.1 - 0.15 10.3 4.1 0.22 9.8 4.1 1.1 1 0 0 1 1 1 0 CDC45-like protein CspB_prodomain PF18425.1 ETO33625.1 - 0.23 11.5 0.1 0.23 11.5 0.1 1.9 2 0 0 2 2 2 0 Csp protease B prodomain DUF4834 PF16118.5 ETO33625.1 - 1.2 10.2 4.6 12 6.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) DENN PF02141.21 ETO33627.1 - 1.5e-22 80.4 3.0 2e-22 80.0 3.0 1.1 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 ETO33627.1 - 0.0013 19.4 0.0 0.0038 17.9 0.0 1.9 1 0 0 1 1 1 1 uDENN domain PDZ PF00595.24 ETO33628.1 - 1.5e-05 25.2 0.0 2.5e-05 24.5 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO33628.1 - 0.0021 18.3 0.0 0.0034 17.7 0.0 1.3 1 0 0 1 1 1 1 PDZ domain Orf78 PF06024.12 ETO33628.1 - 0.075 13.3 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Orf78 (ac78) DUF2946 PF11162.8 ETO33628.1 - 0.12 13.0 0.2 0.18 12.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2946) CoxIIa PF08113.11 ETO33628.1 - 0.49 10.3 4.9 0.73 9.7 4.9 1.2 1 0 0 1 1 1 0 Cytochrome c oxidase subunit IIa family SelP_N PF04592.14 ETO33628.1 - 1.2 8.5 10.7 1.8 7.9 10.7 1.2 1 0 0 1 1 1 0 Selenoprotein P, N terminal region ANAPC4_WD40 PF12894.7 ETO33629.1 - 3e-09 37.0 3.4 0.00013 22.2 0.1 5.8 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO33629.1 - 3.6e-08 33.9 9.3 0.21 12.5 0.0 7.6 7 2 0 7 7 7 2 WD domain, G-beta repeat DUF5122 PF17164.4 ETO33629.1 - 0.007 16.6 3.1 0.7 10.2 0.1 3.8 4 0 0 4 4 4 1 Domain of unknown function (DUF5122) beta-propeller PQQ PF01011.21 ETO33629.1 - 0.02 14.8 0.0 0.1 12.6 0.0 2.3 2 0 0 2 2 2 0 PQQ enzyme repeat SGL PF08450.12 ETO33629.1 - 0.022 14.3 0.2 0.93 9.0 0.1 3.1 3 0 0 3 3 3 0 SMP-30/Gluconolactonase/LRE-like region ROQ_II PF18386.1 ETO33629.1 - 0.037 13.9 0.0 0.083 12.7 0.0 1.5 1 0 0 1 1 1 0 Roquin II domain MAPEG PF01124.18 ETO33631.1 - 0.018 15.0 0.0 0.018 15.0 0.0 2.1 3 0 0 3 3 3 0 MAPEG family WD40 PF00400.32 ETO33632.1 - 1.7e-19 69.8 4.5 4.5e-06 27.3 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33632.1 - 4e-07 29.1 0.9 0.019 13.7 0.1 2.9 1 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33632.1 - 8.1e-05 22.8 0.1 1 9.7 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF641 PF04859.12 ETO33632.1 - 1.2 9.5 3.7 1.9 8.9 3.7 1.3 1 0 0 1 1 1 0 Plant protein of unknown function (DUF641) WD40 PF00400.32 ETO33633.1 - 8e-122 393.6 40.6 2.6e-11 43.9 0.0 12.5 12 0 0 12 12 12 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33633.1 - 8.5e-38 128.5 4.6 0.00081 19.6 0.0 11.9 2 2 10 12 12 12 10 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33633.1 - 7.1e-23 81.4 6.3 0.00026 20.4 0.0 7.7 6 2 2 8 8 8 6 WD40-like domain Ge1_WD40 PF16529.5 ETO33633.1 - 1e-20 74.0 1.4 0.13 11.2 0.0 11.2 1 1 11 12 12 12 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO33633.1 - 8e-11 41.6 6.8 3.9 7.5 0.0 9.2 10 0 0 10 10 10 2 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO33633.1 - 1.7e-08 34.3 1.0 0.13 11.8 0.2 4.6 2 1 1 4 4 4 4 PQQ-like domain Cytochrom_D1 PF02239.16 ETO33633.1 - 0.0003 19.4 5.4 3.8 5.9 0.1 5.0 3 3 3 6 6 6 2 Cytochrome D1 heme domain Pentapeptide PF00805.22 ETO33633.1 - 0.00072 19.1 4.2 0.002 17.7 2.9 2.1 1 1 1 2 2 2 2 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO33633.1 - 0.027 14.6 1.2 0.086 13.0 0.9 2.0 2 0 0 2 2 1 0 Pentapeptide repeats (9 copies) DUF3379 PF11859.8 ETO33633.1 - 0.032 13.6 0.8 0.34 10.2 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3379) PQQ PF01011.21 ETO33633.1 - 0.076 13.0 0.0 52 4.0 0.0 4.7 4 0 0 4 4 4 0 PQQ enzyme repeat Proteasome_A_N PF10584.9 ETO33633.1 - 0.1 12.3 10.3 1.2e+02 2.4 0.0 7.0 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature DUF1652 PF07865.11 ETO33633.1 - 0.14 12.0 0.0 97 2.9 0.0 4.4 3 1 1 4 4 4 0 Protein of unknown function (DUF1652) dsrm PF00035.26 ETO33633.1 - 0.22 12.2 0.8 2.2e+02 2.6 0.0 5.0 7 0 0 7 7 4 0 Double-stranded RNA binding motif Pneumo_M2 PF07380.11 ETO33633.1 - 8.8 6.7 10.4 2.2 8.6 0.5 3.3 2 1 0 3 3 3 0 Pneumovirus M2 protein RUN PF02759.19 ETO33634.1 - 7.2e-08 32.5 0.1 7.2e-08 32.5 0.1 1.9 2 0 0 2 2 2 1 RUN domain CENP-B_dimeris PF09026.10 ETO33635.1 - 0.036 14.4 0.4 0.036 14.4 0.4 2.2 1 1 1 2 2 2 0 Centromere protein B dimerisation domain Serinc PF03348.15 ETO33635.1 - 0.096 11.6 0.6 0.1 11.5 0.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) WD40 PF00400.32 ETO33636.1 - 1.2e-35 120.8 23.9 9.5e-06 26.3 2.2 7.1 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33636.1 - 1.1e-14 54.5 1.3 0.0047 17.2 0.0 5.5 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33636.1 - 1.2e-11 44.0 3.2 0.014 14.0 0.0 5.0 2 2 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33636.1 - 1.4e-05 24.6 5.4 0.057 12.7 0.1 5.0 2 2 4 6 6 6 2 WD40-like domain Nucleoporin_N PF08801.11 ETO33636.1 - 0.0016 17.2 5.4 0.023 13.5 2.4 3.0 1 1 0 2 2 2 1 Nup133 N terminal like PQQ PF01011.21 ETO33636.1 - 0.087 12.8 0.0 0.71 9.9 0.0 2.6 3 0 0 3 3 3 0 PQQ enzyme repeat DUF4949 PF16307.5 ETO33636.1 - 0.095 12.8 0.2 0.29 11.3 0.2 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF4949) DUF851 PF05867.11 ETO33636.1 - 0.11 12.0 0.0 14 5.1 0.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF851) DUF4979 PF16351.5 ETO33636.1 - 0.12 12.6 2.1 5.9 7.1 0.1 3.4 2 1 2 4 4 4 0 Domain of unknown function (DUF4979) PQQ_3 PF13570.6 ETO33636.1 - 0.15 12.6 0.1 14 6.3 0.1 3.4 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.32 ETO33637.1 - 2.6e-34 116.7 35.7 2.4e-06 28.1 1.3 7.8 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO33637.1 - 2.9e-12 46.0 9.9 0.031 12.9 0.1 6.0 1 1 4 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33637.1 - 3.6e-09 36.8 1.7 0.17 12.2 0.0 5.8 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain DUF5570 PF17731.1 ETO33637.1 - 7.3 6.7 8.2 8 6.6 0.2 3.5 2 2 1 4 4 4 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO33638.1 - 1.6e-36 123.7 28.4 9.7e-07 29.4 1.3 7.3 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33638.1 - 7.1e-08 32.6 0.5 0.01 16.1 0.0 5.2 5 1 0 5 5 5 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33638.1 - 8.9e-08 31.2 3.8 0.21 10.2 0.0 4.5 2 2 1 4 4 4 4 Nucleoporin Nup120/160 WD40 PF00400.32 ETO33639.1 - 8.3e-35 118.2 18.9 1.4e-08 35.2 3.1 7.5 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33639.1 - 4.3e-11 43.0 0.7 0.0019 18.5 0.0 5.6 5 1 0 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33639.1 - 1.9e-07 30.2 4.9 0.14 10.8 0.2 4.9 2 2 2 5 5 5 4 Nucleoporin Nup120/160 PQQ_3 PF13570.6 ETO33639.1 - 0.15 12.6 1.7 9.4 6.9 0.3 3.7 4 0 0 4 4 4 0 PQQ-like domain Acetyltransf_1 PF00583.25 ETO33640.1 - 0.00035 20.8 0.0 0.00051 20.3 0.0 1.3 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ETO33640.1 - 0.013 15.6 0.0 0.021 14.9 0.0 1.6 1 1 0 1 1 1 0 Acetyltransferase (GNAT) domain EbsA PF17255.2 ETO33640.1 - 0.023 15.0 0.2 0.038 14.3 0.2 1.3 1 0 0 1 1 1 0 EbsA-like protein Acetyltransf_7 PF13508.7 ETO33640.1 - 0.09 13.2 0.0 0.22 12.0 0.0 1.7 1 0 0 1 1 1 0 Acetyltransferase (GNAT) domain WD40 PF00400.32 ETO33641.1 - 3.1e-21 75.3 12.4 6.4e-05 23.7 0.0 5.3 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33641.1 - 2.3e-05 24.6 0.9 0.99 9.8 0.0 3.9 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33641.1 - 6.9e-05 21.7 0.9 2.8 6.5 0.0 3.5 1 1 1 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33641.1 - 0.00054 19.4 0.2 0.81 9.0 0.1 2.8 2 1 1 3 3 3 3 WD40-like domain DUF1422 PF07226.11 ETO33642.1 - 0.089 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1422) Arm PF00514.23 ETO33643.1 - 0.029 14.4 0.9 7.9 6.7 0.0 3.5 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat PH_2 PF08458.10 ETO33643.1 - 0.22 11.9 3.2 0.4 11.1 0.1 3.1 3 0 0 3 3 3 0 Plant pleckstrin homology-like region PhoQ_Sensor PF08918.10 ETO33643.1 - 0.24 11.2 3.0 0.79 9.5 3.0 1.9 1 0 0 1 1 1 0 PhoQ Sensor WD40 PF00400.32 ETO33644.1 - 4.2e-44 147.6 25.8 6.9e-08 33.0 0.7 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33644.1 - 3.2e-13 49.8 4.5 0.027 14.8 0.0 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33644.1 - 1.1e-07 31.0 12.7 0.0015 17.3 3.0 4.8 1 1 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33644.1 - 2.2e-07 30.5 17.4 0.00046 19.6 1.4 5.4 1 1 3 5 5 5 3 WD40-like domain S-l_SbsC_C PF18316.1 ETO33644.1 - 0.045 14.3 1.0 0.72 10.4 0.3 2.4 2 0 0 2 2 2 0 S-layer protein SbsC C-terminal domain DUF1541 PF07563.11 ETO33644.1 - 0.16 11.8 0.4 10 6.1 0.1 3.5 4 0 0 4 4 4 0 Protein of unknown function (DUF1541) SAM_1 PF00536.30 ETO33645.1 - 0.027 14.9 0.0 0.052 14.0 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO33645.1 - 0.049 13.7 0.0 0.1 12.7 0.0 1.5 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) MOR2-PAG1_N PF14222.6 ETO33645.1 - 0.095 11.6 0.1 0.14 11.1 0.1 1.2 1 0 0 1 1 1 0 Cell morphogenesis N-terminal ALF PF03752.13 ETO33645.1 - 0.12 12.3 0.4 3 7.9 0.1 3.0 4 0 0 4 4 4 0 Short repeats of unknown function DUF2968 PF11180.8 ETO33646.1 - 1.1 8.9 7.8 2 8.0 7.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF2968) YL1 PF05764.13 ETO33647.1 - 0.083 13.0 26.5 0.05 13.7 9.9 2.1 2 0 0 2 2 2 0 YL1 nuclear protein PI3K_1B_p101 PF10486.9 ETO33647.1 - 1.9 6.2 11.7 0.005 14.7 1.8 1.6 2 0 0 2 2 2 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit RNA_polI_A34 PF08208.11 ETO33647.1 - 2.2 8.3 20.9 0.32 11.0 4.9 2.4 2 0 0 2 2 2 0 DNA-directed RNA polymerase I subunit RPA34.5 Vfa1 PF08432.10 ETO33647.1 - 5.8 7.2 23.7 0.9 9.8 6.8 2.3 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Nucleo_P87 PF07267.11 ETO33647.1 - 9.4 4.9 16.7 14 4.4 16.7 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 Ribonuc_2-5A PF06479.12 ETO33648.1 - 0.017 15.3 5.1 0.32 11.2 1.5 2.7 2 1 0 2 2 2 0 Ribonuclease 2-5A DUF3144 PF11342.8 ETO33648.1 - 0.036 14.3 3.4 1.5 9.1 0.1 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3144) DUF4485 PF14846.6 ETO33648.1 - 0.095 12.8 2.9 3.2 7.9 0.1 3.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4485) HEAT PF02985.22 ETO33648.1 - 0.11 12.8 0.5 1.1 9.7 0.0 2.7 3 0 0 3 3 3 0 HEAT repeat Anticodon_1 PF08264.13 ETO33648.1 - 0.54 10.2 5.0 2.8 7.9 0.6 2.8 3 0 0 3 3 3 0 Anticodon-binding domain of tRNA HEAT_2 PF13646.6 ETO33649.1 - 0.00062 20.1 0.0 1.2 9.5 0.0 3.0 3 0 0 3 3 3 1 HEAT repeats HEAT PF02985.22 ETO33649.1 - 0.012 15.8 0.3 62 4.2 0.0 4.0 4 0 0 4 4 4 0 HEAT repeat FPL PF09758.9 ETO33649.1 - 0.014 15.4 3.0 2.1 8.4 2.8 3.0 1 1 1 2 2 2 0 Uncharacterised conserved protein MMS19_N PF14500.6 ETO33649.1 - 0.034 13.7 0.7 0.072 12.7 0.6 1.7 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II MazG PF03819.17 ETO33649.1 - 0.045 13.9 1.1 6.5 7.0 0.1 3.1 3 0 0 3 3 3 0 MazG nucleotide pyrophosphohydrolase domain EAL PF00563.20 ETO33649.1 - 0.052 13.1 0.6 0.083 12.4 0.6 1.4 1 1 0 1 1 1 0 EAL domain ENTH PF01417.20 ETO33649.1 - 0.058 13.5 5.4 0.16 12.1 1.8 2.2 2 0 0 2 2 2 0 ENTH domain DUF1421 PF07223.11 ETO33649.1 - 0.068 13.0 1.7 0.07 13.0 0.1 1.8 2 0 0 2 2 2 0 UBA-like domain (DUF1421) MMS19_C PF12460.8 ETO33649.1 - 0.095 11.8 3.9 0.25 10.4 3.2 1.7 1 1 1 2 2 2 0 RNAPII transcription regulator C-terminal TAP42 PF04177.12 ETO33649.1 - 0.13 11.4 6.3 0.053 12.6 4.2 1.4 1 1 0 1 1 1 0 TAP42-like family IPK PF03770.16 ETO33649.1 - 0.14 12.0 3.2 0.25 11.2 3.1 1.5 1 1 0 1 1 1 0 Inositol polyphosphate kinase Anticodon_1 PF08264.13 ETO33649.1 - 0.37 10.8 4.0 2.5 8.0 0.1 2.9 2 2 0 2 2 2 0 Anticodon-binding domain of tRNA MA3 PF02847.17 ETO33649.1 - 0.57 10.2 5.5 1.5 8.8 3.1 2.8 1 1 1 3 3 3 0 MA3 domain Mob1_phocein PF03637.17 ETO33649.1 - 1.6 8.7 8.4 0.99 9.4 4.0 2.0 1 1 1 2 2 2 0 Mob1/phocein family DivIC PF04977.15 ETO33650.1 - 1.2 8.9 9.7 4.1 7.2 9.7 1.8 1 1 0 1 1 1 0 Septum formation initiator DUF5340 PF17275.2 ETO33650.1 - 4.7 7.4 6.9 2.4 8.4 4.7 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5340) Filament PF00038.21 ETO33653.1 - 0.002 17.8 26.1 0.0025 17.4 26.1 1.0 1 0 0 1 1 1 1 Intermediate filament protein FPP PF05911.11 ETO33653.1 - 0.0023 16.2 21.6 0.0027 16.0 21.6 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 ETO33653.1 - 0.008 15.1 18.9 0.008 15.1 18.9 2.1 1 1 1 2 2 2 1 Spc7 kinetochore protein PgaD PF13994.6 ETO33653.1 - 0.2 11.7 0.2 0.2 11.7 0.2 2.8 4 0 0 4 4 4 0 PgaD-like protein UPF0242 PF06785.11 ETO33653.1 - 3.6 7.7 34.2 6.3 6.9 14.6 2.3 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Atg14 PF10186.9 ETO33653.1 - 7.8 5.5 25.1 0.18 10.9 16.6 1.9 1 1 1 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 WD40 PF00400.32 ETO33654.1 - 3.1e-23 81.6 8.7 0.00012 22.8 0.1 5.7 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33654.1 - 7.2e-12 45.4 0.4 0.01 16.1 0.0 4.2 2 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33654.1 - 4.7e-06 26.1 11.1 0.017 14.5 1.3 3.4 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO33654.1 - 1.8e-05 23.6 2.6 0.051 12.2 0.1 3.5 1 1 2 3 3 3 3 Nucleoporin Nup120/160 HSP70 PF00012.20 ETO33655.1 - 1.4e-16 59.8 5.9 2.6e-10 39.2 3.3 2.0 1 1 1 2 2 2 2 Hsp70 protein EspB PF05802.11 ETO33655.1 - 0.0037 17.3 2.0 0.0037 17.3 2.0 1.5 2 0 0 2 2 2 1 Enterobacterial EspB protein Filament PF00038.21 ETO33655.1 - 0.01 15.4 0.8 0.013 15.1 0.8 1.1 1 0 0 1 1 1 0 Intermediate filament protein EF-hand_6 PF13405.6 ETO33656.1 - 1.4e-07 30.8 1.7 0.00023 20.8 0.1 3.0 2 0 0 2 2 2 2 EF-hand domain EF-hand_7 PF13499.6 ETO33656.1 - 1.3e-06 28.8 2.1 3.3e-05 24.2 0.3 2.7 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO33656.1 - 1.3e-06 27.5 0.2 8.5e-05 21.8 0.1 2.6 2 0 0 2 2 2 1 EF hand EF-hand_5 PF13202.6 ETO33656.1 - 0.001 18.4 0.7 0.0034 16.8 0.2 2.1 2 0 0 2 2 2 1 EF hand EF-hand_8 PF13833.6 ETO33656.1 - 0.0014 18.4 0.1 0.018 14.9 0.1 2.3 2 0 0 2 2 2 1 EF-hand domain pair DUF3037 PF11236.8 ETO33657.1 - 0.078 13.4 0.0 0.4 11.1 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF3037) p450 PF00067.22 ETO33658.1 - 1.2e-39 136.4 0.0 1.5e-39 136.1 0.0 1.0 1 0 0 1 1 1 1 Cytochrome P450 Y_phosphatase2 PF03162.13 ETO33659.1 - 0.019 14.6 0.2 0.02 14.5 0.2 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family LRR_4 PF12799.7 ETO33660.1 - 1.4e-05 25.4 5.0 1.4e-05 25.4 5.0 3.6 3 1 1 4 4 4 2 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO33660.1 - 4.8e-05 23.0 8.0 0.034 13.9 0.1 3.2 3 0 0 3 3 3 2 Leucine rich repeat LRR_9 PF14580.6 ETO33660.1 - 0.0021 17.6 5.4 0.0057 16.2 1.6 2.6 1 1 1 2 2 2 1 Leucine-rich repeat LRR_1 PF00560.33 ETO33660.1 - 0.0035 17.7 1.4 2.1 9.2 0.2 3.5 2 0 0 2 2 2 1 Leucine Rich Repeat TSNR_N PF04705.12 ETO33660.1 - 0.14 12.2 0.0 0.36 10.9 0.0 1.6 1 0 0 1 1 1 0 Thiostrepton-resistance methylase, N terminus LRR_6 PF13516.6 ETO33660.1 - 0.18 11.9 4.0 7.3 6.9 0.3 2.8 2 0 0 2 2 2 0 Leucine Rich repeat SAMP PF05924.11 ETO33660.1 - 2.1 7.8 4.1 3.9 6.9 4.1 1.4 1 0 0 1 1 1 0 SAMP Motif dCMP_cyt_deam_1 PF00383.23 ETO33661.1 - 2.9e-27 94.5 0.0 5.6e-27 93.6 0.0 1.5 1 1 0 1 1 1 1 Cytidine and deoxycytidylate deaminase zinc-binding region MafB19-deam PF14437.6 ETO33661.1 - 1.2e-14 54.2 0.0 1.6e-14 53.9 0.0 1.1 1 0 0 1 1 1 1 MafB19-like deaminase SNAD4 PF18750.1 ETO33661.1 - 0.063 13.4 0.1 0.11 12.7 0.1 1.4 1 0 0 1 1 1 0 Secreted Novel AID/APOBEC-like Deaminase 4 APOBEC3 PF18771.1 ETO33661.1 - 0.089 12.9 0.2 0.21 11.7 0.1 1.7 2 0 0 2 2 2 0 APOBEC3 CAP_GLY PF01302.25 ETO33662.1 - 2.9e-05 24.0 0.3 5e-05 23.2 0.3 1.4 1 0 0 1 1 1 1 CAP-Gly domain DUF3754 PF12576.8 ETO33663.1 - 2.9e-11 43.5 0.0 6e-11 42.4 0.0 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF3754) Nup160 PF11715.8 ETO33663.1 - 0.0074 15.0 0.2 0.16 10.6 0.1 2.2 2 0 0 2 2 2 1 Nucleoporin Nup120/160 WD40 PF00400.32 ETO33663.1 - 0.016 16.1 0.3 0.058 14.3 0.3 2.0 1 0 0 1 1 1 0 WD domain, G-beta repeat DUF3435 PF11917.8 ETO33663.1 - 0.057 12.3 0.0 0.084 11.8 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3435) WD40 PF00400.32 ETO33664.1 - 7.7e-24 83.5 7.9 3.2e-07 30.9 0.4 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO33664.1 - 2.5e-08 33.1 2.1 0.0012 17.6 0.1 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33664.1 - 5.8e-08 32.9 0.0 0.025 14.9 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33664.1 - 0.00023 20.6 1.6 0.0057 16.0 0.2 2.2 1 1 1 2 2 2 1 WD40-like domain DUF4221 PF13970.6 ETO33664.1 - 0.01 15.5 4.1 0.092 12.3 0.4 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Arena_nucleocap PF00843.17 ETO33664.1 - 0.073 12.0 0.2 5.5 5.8 0.0 2.6 3 0 0 3 3 3 0 Arenavirus nucleocapsid N-terminal domain APO_RNA-bind PF05634.11 ETO33665.1 - 0.13 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 APO RNA-binding Ank_2 PF12796.7 ETO33666.1 - 1.4e-11 44.8 0.3 9.1e-07 29.4 0.2 2.1 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO33666.1 - 2.4e-09 37.5 0.1 1.4e-05 25.5 0.0 2.2 2 0 0 2 2 2 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO33666.1 - 4.2e-09 36.5 0.2 9.9e-07 28.9 0.1 2.2 1 1 1 2 2 2 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO33666.1 - 0.00038 20.7 0.2 2.5 8.9 0.0 3.5 4 0 0 4 4 4 2 Ankyrin repeat Ank PF00023.30 ETO33666.1 - 0.00051 20.4 0.1 0.058 13.9 0.0 3.1 4 0 0 4 4 4 1 Ankyrin repeat PhoU_div PF01865.16 ETO33666.1 - 0.083 12.2 0.1 0.1 11.9 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function DUF47 Spore_III_AF PF09581.10 ETO33667.1 - 0.12 12.4 0.0 0.17 11.9 0.0 1.2 1 0 0 1 1 1 0 Stage III sporulation protein AF (Spore_III_AF) MerC PF03203.14 ETO33667.1 - 2.3 8.7 11.1 11 6.6 4.6 3.6 2 2 1 3 3 3 0 MerC mercury resistance protein Mito_carr PF00153.27 ETO33668.1 - 1.1e-25 89.4 0.0 1.3e-17 63.5 0.0 2.0 2 0 0 2 2 2 2 Mitochondrial carrier protein Glycophorin_A PF01102.18 ETO33668.1 - 0.016 15.5 0.0 0.024 14.9 0.0 1.3 1 0 0 1 1 1 0 Glycophorin A SIN1_PH PF16979.5 ETO33669.1 - 0.088 13.1 0.0 0.37 11.1 0.0 1.9 1 1 0 1 1 1 0 SAPK-interacting protein 1 (Sin1), Pleckstrin-homology Bromodomain PF00439.25 ETO33670.1 - 4.1e-18 65.2 0.0 9.2e-18 64.1 0.0 1.6 1 0 0 1 1 1 1 Bromodomain DUF1631 PF07793.11 ETO33670.1 - 0.0019 16.7 0.2 0.0031 16.0 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF1631) Glyoxalase PF00903.25 ETO33671.1 - 1.1e-08 35.3 0.1 5.1e-08 33.2 0.1 2.0 1 1 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_2 PF12681.7 ETO33671.1 - 2.6e-05 24.1 0.0 5.1e-05 23.2 0.0 1.4 1 0 0 1 1 1 1 Glyoxalase-like domain Glyoxalase_4 PF13669.6 ETO33671.1 - 0.0035 17.6 0.0 0.0054 17.0 0.0 1.3 1 0 0 1 1 1 1 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily Glyoxalase_3 PF13468.6 ETO33671.1 - 0.032 14.4 0.0 0.044 13.9 0.0 1.5 1 1 0 1 1 1 0 Glyoxalase-like domain OST-HTH PF12872.7 ETO33672.1 - 4.4e-06 26.4 0.4 8.6e-05 22.3 0.0 2.7 3 1 0 3 3 3 1 OST-HTH/LOTUS domain PgdA_N PF18627.1 ETO33673.1 - 0.12 12.0 3.3 0.22 11.1 0.2 2.1 2 0 0 2 2 2 0 Peptidoglycan GlcNAc deacetylase N-terminal domain Inhibitor_I24 PF10465.9 ETO33675.1 - 0.023 14.7 0.2 0.03 14.3 0.1 1.3 1 1 0 1 1 1 0 PinA peptidase inhibitor TAF1_subA PF14929.6 ETO33675.1 - 0.029 13.8 0.6 0.032 13.6 0.6 1.0 1 0 0 1 1 1 0 TAF RNA Polymerase I subunit A DUF3268 PF11672.8 ETO33675.1 - 0.074 13.4 0.2 0.95 9.8 0.1 2.0 2 0 0 2 2 2 0 zinc-finger-containing domain DUF5320 PF17253.2 ETO33676.1 - 0.018 16.1 0.8 0.051 14.6 0.8 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5320) U-box PF04564.15 ETO33676.1 - 0.12 12.6 0.0 0.4 10.9 0.0 1.9 1 0 0 1 1 1 0 U-box domain DB PF01682.19 ETO33676.1 - 0.5 10.7 5.6 0.36 11.2 3.0 2.1 2 0 0 2 2 2 0 DB module WD40 PF00400.32 ETO33677.1 - 8.4e-10 39.1 3.6 0.00034 21.4 0.0 5.0 4 1 1 5 5 5 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33677.1 - 1.7e-07 31.4 0.0 0.13 12.5 0.0 3.8 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33677.1 - 0.0027 16.7 0.0 0.025 13.5 0.0 2.4 2 1 1 3 3 3 1 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO33677.1 - 0.022 14.7 0.0 1.3 8.9 0.0 2.8 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A Coatomer_WDAD PF04053.14 ETO33677.1 - 0.1 11.6 0.0 4.5 6.2 0.0 2.1 2 0 0 2 2 2 0 Coatomer WD associated region RAB3GAP2_N PF14655.6 ETO33677.1 - 0.11 11.7 0.0 4.6 6.4 0.0 2.3 2 0 0 2 2 2 0 Rab3 GTPase-activating protein regulatory subunit N-terminus ANAPC4_WD40 PF12894.7 ETO33678.1 - 0.0014 18.9 0.0 0.0039 17.5 0.0 1.7 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO33678.1 - 0.025 15.5 0.2 0.025 15.5 0.2 2.3 2 1 0 2 2 2 0 WD domain, G-beta repeat Carbam_trans_C PF16861.5 ETO33679.1 - 0.025 14.2 1.3 0.065 12.8 0.2 1.8 1 1 1 2 2 2 0 Carbamoyltransferase C-terminus Phage_Coat_A PF05357.13 ETO33679.1 - 0.045 13.6 0.8 8.9 6.2 0.1 2.1 2 0 0 2 2 2 0 Phage Coat Protein A UPF0242 PF06785.11 ETO33680.1 - 0.016 15.3 10.5 0.016 15.3 10.5 2.2 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0242) N-terminus Fe-ADH PF00465.19 ETO33680.1 - 0.06 12.2 0.6 0.083 11.7 0.6 1.2 1 0 0 1 1 1 0 Iron-containing alcohol dehydrogenase DBD_Tnp_Mut PF03108.15 ETO33680.1 - 0.098 12.7 3.1 0.24 11.4 3.1 1.6 1 0 0 1 1 1 0 MuDR family transposase Rieske_3 PF18465.1 ETO33680.1 - 0.43 10.9 4.3 0.25 11.6 1.2 2.1 1 1 2 3 3 3 0 Rieske 3Fe-4S LCM PF04072.14 ETO33681.1 - 3e-16 59.9 0.0 4.5e-16 59.3 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase Glyco_hydro_67N PF03648.14 ETO33682.1 - 0.083 13.2 0.9 0.26 11.6 0.9 1.9 1 0 0 1 1 1 0 Glycosyl hydrolase family 67 N-terminus SAM_1 PF00536.30 ETO33683.1 - 4.4e-09 36.6 0.5 8.8e-09 35.7 0.5 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO33683.1 - 5.7e-09 36.0 0.2 1.5e-08 34.6 0.2 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO33683.1 - 0.0096 15.9 0.1 0.039 13.9 0.1 2.1 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain Spore_YhaL PF14147.6 ETO33683.1 - 0.73 9.6 0.1 0.73 9.6 0.1 2.9 3 0 0 3 3 3 0 Sporulation protein YhaL Trypan_glycop PF00913.19 ETO33683.1 - 1.4 8.1 13.6 1.2 8.3 11.8 1.7 1 1 1 2 2 2 0 Trypanosome variant surface glycoprotein (A-type) DUF3584 PF12128.8 ETO33683.1 - 1.9 5.9 35.8 2.6 5.5 35.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Kinesin PF00225.23 ETO33684.1 - 1.8e-102 342.7 1.6 1.8e-102 342.7 1.6 1.7 2 1 0 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO33684.1 - 2e-22 79.7 0.5 4.3e-22 78.7 0.5 1.6 1 0 0 1 1 1 1 Microtubule binding CAMSAP_CH PF11971.8 ETO33684.1 - 0.031 14.1 0.0 0.075 12.9 0.0 1.6 1 0 0 1 1 1 0 CAMSAP CH domain Sld7_N PF18636.1 ETO33684.1 - 0.062 13.6 0.1 0.45 10.9 0.0 2.3 2 0 0 2 2 2 0 Mitochondrial morphogenesis protein SLD7 N-terminal domain HIP1_clath_bdg PF16515.5 ETO33684.1 - 0.98 10.1 5.7 0.61 10.7 2.1 2.5 2 0 0 2 2 2 0 Clathrin-binding domain of Huntingtin-interacting protein 1 4HBT_2 PF13279.6 ETO33685.1 - 2.2e-19 70.2 0.5 3.1e-19 69.7 0.5 1.1 1 0 0 1 1 1 1 Thioesterase-like superfamily 4HBT PF03061.22 ETO33685.1 - 0.00017 21.8 0.0 0.0003 21.1 0.0 1.3 1 0 0 1 1 1 1 Thioesterase superfamily Acyl-ACP_TE PF01643.17 ETO33685.1 - 1.2 8.3 6.0 29 3.8 6.0 2.1 1 1 0 1 1 1 0 Acyl-ACP thioesterase NAAA-beta PF15508.6 ETO33686.1 - 6.8e-11 42.3 2.8 8.6e-11 42.0 0.4 2.6 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.18 ETO33686.1 - 0.00042 20.1 0.0 0.00092 18.9 0.0 1.6 1 0 0 1 1 1 1 Linear amide C-N hydrolases, choloylglycine hydrolase family s48_45 PF07422.13 ETO33686.1 - 0.064 13.8 0.0 0.35 11.5 0.0 2.3 1 0 0 1 1 1 0 Sexual stage antigen s48/45 domain CENP-F_leu_zip PF10473.9 ETO33686.1 - 8.2 6.5 37.7 56 3.8 28.2 2.6 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ORF6C PF10552.9 ETO33687.1 - 0.24 11.5 6.8 0.27 11.4 0.2 2.7 3 0 0 3 3 3 0 ORF6C domain ROS_MUCR PF05443.11 ETO33688.1 - 0.021 14.9 4.3 0.052 13.6 1.1 2.3 1 1 0 2 2 2 0 ROS/MUCR transcriptional regulator protein FlxA PF14282.6 ETO33688.1 - 0.36 10.8 41.9 0.12 12.4 12.3 2.4 1 1 1 2 2 2 0 FlxA-like protein TMPIT PF07851.13 ETO33688.1 - 0.9 8.7 14.2 1.6 7.9 14.2 1.4 1 0 0 1 1 1 0 TMPIT-like protein DUF3332 PF11810.8 ETO33688.1 - 0.91 9.1 10.4 1.8 8.1 10.4 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3332) Pro-rich_19 PF15455.6 ETO33688.1 - 1 8.5 3.8 0.37 9.9 0.1 2.0 3 0 0 3 3 3 0 Proline-rich 19 V_ATPase_I PF01496.19 ETO33688.1 - 2.5 5.9 15.5 3.3 5.5 15.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4407 PF14362.6 ETO33688.1 - 3.9 6.7 12.5 5.9 6.2 12.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF2615 PF11027.8 ETO33689.1 - 0.0048 17.0 1.5 2.1 8.5 0.0 3.5 4 0 0 4 4 4 1 Protein of unknown function (DUF2615) ISN1 PF06437.11 ETO33689.1 - 0.0057 15.6 0.8 0.0092 14.9 0.8 1.3 1 0 0 1 1 1 1 IMP-specific 5'-nucleotidase Peptidase_S49_N PF08496.10 ETO33689.1 - 0.34 11.0 1.6 1.1 9.3 1.6 1.8 1 0 0 1 1 1 0 Peptidase family S49 N-terminal EMC1_C PF07774.13 ETO33689.1 - 0.59 9.8 7.2 1.9 8.1 1.8 2.5 2 0 0 2 2 2 0 ER membrane protein complex subunit 1, C-terminal Chordopox_G3 PF06129.12 ETO33689.1 - 0.71 10.6 3.5 2.4 8.9 0.2 3.1 2 0 0 2 2 2 0 Chordopoxvirus G3 protein NPCC PF08058.11 ETO33689.1 - 0.97 9.5 3.3 0.94 9.5 0.2 2.6 2 1 0 2 2 2 0 Nuclear pore complex component Neur_chan_memb PF02932.16 ETO33689.1 - 2.1 8.3 4.8 14 5.6 0.1 3.2 3 0 0 3 3 3 0 Neurotransmitter-gated ion-channel transmembrane region HemY_N PF07219.13 ETO33689.1 - 2.2 8.5 6.4 0.42 10.8 0.1 3.1 3 0 0 3 3 3 0 HemY protein N-terminus OppC_N PF12911.7 ETO33689.1 - 5.4 7.1 7.3 61 3.7 0.0 4.4 4 0 0 4 4 4 0 N-terminal TM domain of oligopeptide transport permease C DEP PF00610.21 ETO33691.1 - 3.4e-06 27.0 0.0 6.7e-06 26.1 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) CotJA PF11007.8 ETO33691.1 - 0.32 10.9 1.1 1.8 8.5 0.0 2.6 3 0 0 3 3 3 0 Spore coat associated protein JA (CotJA) AP3D1 PF06375.11 ETO33691.1 - 0.6 10.3 7.1 0.99 9.6 7.1 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 TLP-20 PF06088.11 ETO33692.1 - 0.014 15.3 5.4 0.024 14.5 5.4 1.3 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) CPSF100_C PF13299.6 ETO33692.1 - 0.068 13.4 1.6 0.1 12.8 1.6 1.3 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal DUF4834 PF16118.5 ETO33692.1 - 0.072 14.1 4.0 0.13 13.3 4.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) SAM_1 PF00536.30 ETO33692.1 - 0.13 12.7 0.0 0.5 10.9 0.0 1.8 2 0 0 2 2 2 0 SAM domain (Sterile alpha motif) DUF913 PF06025.12 ETO33692.1 - 0.18 10.7 2.4 0.26 10.2 2.4 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RPN2_C PF18004.1 ETO33692.1 - 0.32 10.9 9.4 0.44 10.4 9.4 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Presenilin PF01080.17 ETO33692.1 - 0.37 9.5 4.3 0.43 9.3 4.3 1.1 1 0 0 1 1 1 0 Presenilin CRA PF06589.11 ETO33692.1 - 0.37 10.9 7.1 0.64 10.1 7.1 1.3 1 0 0 1 1 1 0 Circumsporozoite-related antigen (CRA) Zip PF02535.22 ETO33692.1 - 0.51 9.5 2.5 0.62 9.2 2.5 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter CobT PF06213.12 ETO33692.1 - 0.7 9.2 8.1 0.95 8.8 8.1 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4614 PF15391.6 ETO33692.1 - 1 9.3 9.5 1.4 8.8 9.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) NPR3 PF03666.13 ETO33692.1 - 1.9 7.2 8.5 2.4 6.8 8.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 FAM176 PF14851.6 ETO33692.1 - 1.9 8.1 6.3 3.1 7.4 6.3 1.4 1 0 0 1 1 1 0 FAM176 family AIF_C PF14721.6 ETO33692.1 - 3.9 7.9 6.5 5.9 7.3 6.5 1.3 1 0 0 1 1 1 0 Apoptosis-inducing factor, mitochondrion-associated, C-term Voltage_CLC PF00654.20 ETO33693.1 - 0.12 11.6 0.0 0.15 11.3 0.0 1.2 1 0 0 1 1 1 0 Voltage gated chloride channel Zip PF02535.22 ETO33693.1 - 0.12 11.5 0.4 0.23 10.6 0.3 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter GWT1 PF06423.12 ETO33693.1 - 0.16 12.1 6.4 0.35 11.0 5.1 2.1 2 0 0 2 2 2 0 GWT1 SPATA19 PF15212.6 ETO33693.1 - 0.18 12.1 4.6 1.4 9.2 2.0 2.7 2 1 1 3 3 3 0 Spermatogenesis-associated protein 19, mitochondrial OAD_gamma PF04277.13 ETO33693.1 - 0.18 12.4 5.6 51 4.6 0.3 4.1 4 0 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain Tubulin PF00091.25 ETO33694.1 - 7.9e-62 209.0 0.1 1.3e-61 208.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO33694.1 - 3.9e-28 98.2 0.2 8.4e-28 97.1 0.0 1.7 2 0 0 2 2 2 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO33694.1 - 2.1e-05 24.8 0.0 5e-05 23.6 0.0 1.6 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_3 PF14881.6 ETO33694.1 - 0.0011 18.7 0.0 0.002 17.8 0.0 1.5 1 0 0 1 1 1 1 Tubulin domain Tubulin_2 PF13809.6 ETO33694.1 - 0.0066 15.7 0.0 0.011 14.9 0.0 1.3 1 0 0 1 1 1 1 Tubulin like Melibiase_2 PF16499.5 ETO33695.1 - 1.9e-70 237.3 3.1 2.9e-70 236.7 3.1 1.3 1 0 0 1 1 1 1 Alpha galactosidase A Melibiase_C PF17801.1 ETO33695.1 - 7.3e-18 64.4 0.5 2.9e-17 62.5 0.4 2.0 1 1 1 2 2 2 1 Alpha galactosidase C-terminal beta sandwich domain Melibiase PF02065.18 ETO33695.1 - 0.00033 19.7 0.1 0.00088 18.3 0.0 1.6 2 0 0 2 2 2 1 Melibiase Melibiase_2_C PF17450.2 ETO33695.1 - 0.043 14.1 0.0 0.084 13.1 0.0 1.4 1 0 0 1 1 1 0 Alpha galactosidase A C-terminal beta sandwich domain Raffinose_syn PF05691.12 ETO33695.1 - 0.067 11.0 0.2 0.097 10.4 0.2 1.1 1 0 0 1 1 1 0 Raffinose synthase or seed imbibition protein Sip1 ACBP PF00887.19 ETO33697.1 - 9.1e-14 51.5 0.5 2.1e-13 50.3 0.1 1.9 2 1 0 2 2 2 1 Acyl CoA binding protein EF-hand_6 PF13405.6 ETO33698.1 - 1.1e-07 31.2 3.6 0.0038 17.0 0.1 3.6 3 0 0 3 3 3 3 EF-hand domain EF-hand_7 PF13499.6 ETO33698.1 - 3e-05 24.4 4.1 0.00025 21.4 1.2 2.5 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_1 PF00036.32 ETO33698.1 - 5.3e-05 22.5 5.2 0.0013 18.1 0.0 3.8 4 0 0 4 4 4 1 EF hand EF-hand_5 PF13202.6 ETO33698.1 - 0.00042 19.7 5.0 0.0033 16.8 0.1 3.6 4 0 0 4 4 4 1 EF hand EF-hand_8 PF13833.6 ETO33698.1 - 0.019 14.8 1.7 0.043 13.7 0.1 2.5 3 0 0 3 3 3 0 EF-hand domain pair Eno-Rase_FAD_bd PF07055.12 ETO33698.1 - 0.086 13.3 2.3 2.9 8.4 0.2 2.5 2 0 0 2 2 2 0 Enoyl reductase FAD binding domain Pes-10 PF07149.11 ETO33698.1 - 0.16 11.0 6.2 0.39 9.7 6.2 1.6 1 1 0 1 1 1 0 Pes-10 Tudor-knot PF11717.8 ETO33699.1 - 8.3e-05 22.4 2.0 0.00046 20.0 2.0 2.3 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain Amelogenin PF02948.15 ETO33699.1 - 0.072 13.7 13.8 0.047 14.3 11.9 1.6 1 1 0 1 1 1 0 Amelogenin DUF2838 PF10998.8 ETO33700.1 - 0.03 14.6 1.5 0.03 14.6 1.5 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF2838) TPR_MalT PF17874.1 ETO33700.1 - 0.039 13.3 1.5 0.89 8.9 0.3 2.2 2 0 0 2 2 2 0 MalT-like TPR region PH PF00169.29 ETO33703.1 - 2.2e-05 24.9 2.1 0.00012 22.5 2.2 2.3 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO33703.1 - 0.0047 17.2 0.0 0.013 15.7 0.0 1.8 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO33703.1 - 0.031 14.7 13.3 0.43 11.0 13.3 2.8 1 1 0 1 1 1 0 Pleckstrin homology domain GREB1 PF15782.5 ETO33703.1 - 0.45 7.6 14.7 0.55 7.3 14.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer MG4 PF17789.1 ETO33703.1 - 0.72 10.0 5.9 1.9 8.7 0.0 2.7 3 0 0 3 3 3 0 Macroglobulin domain MG4 DUF4407 PF14362.6 ETO33703.1 - 1.8 7.9 6.1 2.3 7.5 6.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Membralin PF09746.9 ETO33703.1 - 2.8 6.9 8.5 3.5 6.6 8.5 1.3 1 0 0 1 1 1 0 Tumour-associated protein LRR_6 PF13516.6 ETO33704.1 - 0.0047 16.9 0.0 0.19 11.9 0.0 3.1 3 0 0 3 3 3 1 Leucine Rich repeat ALIX_LYPXL_bnd PF13949.6 ETO33705.1 - 1.4e-38 132.9 9.6 8.5e-24 84.4 4.0 3.1 3 1 1 4 4 4 2 ALIX V-shaped domain binding to HIV DUF3951 PF13131.6 ETO33705.1 - 0.032 14.4 0.7 0.069 13.4 0.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3951) FTO_CTD PF12934.7 ETO33705.1 - 0.073 12.8 0.4 0.27 11.0 0.4 2.0 1 0 0 1 1 1 0 FTO C-terminal domain ParE_toxin PF05016.15 ETO33705.1 - 0.13 12.9 0.5 14 6.4 0.1 2.7 2 0 0 2 2 2 0 ParE toxin of type II toxin-antitoxin system, parDE KELK PF15796.5 ETO33705.1 - 0.35 11.4 15.2 1.1 9.7 2.5 4.5 3 1 1 4 4 4 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase Laminin_II PF06009.12 ETO33705.1 - 0.35 10.9 6.8 0.11 12.5 0.8 2.9 2 1 1 3 3 3 0 Laminin Domain II DUF883 PF05957.13 ETO33705.1 - 0.6 10.8 5.6 0.76 10.4 0.9 3.2 2 1 3 5 5 5 0 Bacterial protein of unknown function (DUF883) YtxH PF12732.7 ETO33705.1 - 6.7 7.3 9.1 3.3 8.3 0.1 3.8 3 1 0 3 3 3 0 YtxH-like protein Zip PF02535.22 ETO33706.1 - 0.00017 20.9 9.0 0.0054 16.0 9.0 2.2 1 1 0 1 1 1 1 ZIP Zinc transporter Roughex PF06020.11 ETO33706.1 - 0.054 12.6 21.7 0.081 12.0 21.7 1.4 1 0 0 1 1 1 0 Drosophila roughex protein CDC45 PF02724.14 ETO33706.1 - 0.24 9.6 22.1 0.34 9.2 22.1 1.2 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ETO33706.1 - 1.8 6.8 9.2 3 6.2 9.2 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Nop14 PF04147.12 ETO33706.1 - 2.6 6.1 33.4 3.6 5.7 33.4 1.1 1 0 0 1 1 1 0 Nop14-like family RskA PF10099.9 ETO33706.1 - 4 7.7 13.7 32 4.8 13.5 2.2 1 1 0 1 1 1 0 Anti-sigma-K factor rskA Hid1 PF12722.7 ETO33706.1 - 7 4.6 20.5 9.6 4.2 20.5 1.2 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein WD40 PF00400.32 ETO33707.1 - 4.9e-40 134.8 23.7 1.9e-06 28.5 1.1 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33707.1 - 7.3e-15 55.0 1.1 0.017 15.4 0.0 5.5 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33707.1 - 1.2e-07 31.3 7.0 0.0023 17.3 0.3 4.9 2 2 2 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO33707.1 - 2.3e-07 29.9 3.8 0.024 13.3 0.7 4.7 3 1 0 4 4 4 4 Nucleoporin Nup120/160 Peptidase_C14 PF00656.22 ETO33708.1 - 5.7e-09 36.3 3.7 1.7e-08 34.7 2.1 2.3 2 1 0 2 2 2 1 Caspase domain Suc_Fer-like PF06999.12 ETO33708.1 - 0.054 13.3 1.7 0.22 11.4 0.7 2.6 2 1 0 2 2 2 0 Sucrase/ferredoxin-like WD40 PF00400.32 ETO33711.1 - 1.6e-20 73.0 11.0 8.9e-05 23.2 0.0 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO33711.1 - 1e-06 27.7 1.4 0.4 9.3 0.0 3.6 2 2 1 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33711.1 - 0.00014 22.1 0.1 8.3 6.8 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Kelch_1 PF01344.25 ETO33714.1 - 7.8e-06 25.4 0.3 3.7e-05 23.2 0.2 2.0 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO33714.1 - 4.5e-05 23.3 0.2 0.072 13.1 0.3 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO33714.1 - 9.6e-05 22.3 2.0 0.014 15.4 0.2 2.8 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO33714.1 - 0.0053 16.7 0.0 0.013 15.5 0.0 1.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO33714.1 - 0.02 15.2 0.0 0.031 14.6 0.0 1.3 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33714.1 - 0.026 14.8 1.9 0.16 12.3 1.0 2.2 1 1 1 2 2 2 0 Kelch motif DcpS_C PF11969.8 ETO33714.1 - 0.076 13.5 0.0 0.11 13.0 0.0 1.2 1 0 0 1 1 1 0 Scavenger mRNA decapping enzyme C-term binding NCBP3 PF10309.9 ETO33714.1 - 0.26 11.2 1.6 0.64 9.9 1.6 1.8 1 1 0 1 1 1 0 Nuclear cap-binding protein subunit 3 E7R PF17467.2 ETO33715.1 - 0.077 13.2 1.2 8.2 6.7 0.2 2.3 1 1 1 2 2 2 0 Viral Protein E7 WD40 PF00400.32 ETO33716.1 - 2.5e-16 59.7 12.6 2.1e-06 28.4 0.7 4.5 5 0 0 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33716.1 - 0.00086 19.6 0.1 0.51 10.7 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Secretin_N_2 PF07655.13 ETO33717.1 - 0.017 15.7 9.1 0.032 14.8 9.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain BatD PF13584.6 ETO33717.1 - 0.058 12.2 0.2 1.2 7.9 0.0 2.1 2 0 0 2 2 2 0 Oxygen tolerance Orf78 PF06024.12 ETO33717.1 - 0.073 13.4 0.6 0.073 13.4 0.6 3.8 3 1 1 4 4 4 0 Orf78 (ac78) Menin PF05053.13 ETO33717.1 - 1.3 7.3 5.6 1.9 6.8 5.6 1.1 1 0 0 1 1 1 0 Menin O-FucT PF10250.9 ETO33720.1 - 0.00074 19.3 0.0 0.0021 17.9 0.0 1.6 1 1 0 1 1 1 1 GDP-fucose protein O-fucosyltransferase Peripla_BP_7 PF18610.1 ETO33721.1 - 0.017 15.2 0.7 2.4 8.4 0.0 2.3 2 0 0 2 2 2 0 Periplasmic binding protein domain Spc24 PF08286.11 ETO33722.1 - 0.021 15.0 1.6 0.077 13.2 1.6 2.0 1 0 0 1 1 1 0 Spc24 subunit of Ndc80 DivIC PF04977.15 ETO33722.1 - 0.19 11.5 2.4 0.55 10.0 2.4 1.8 1 0 0 1 1 1 0 Septum formation initiator WD40 PF00400.32 ETO33723.1 - 0.015 16.1 0.3 0.028 15.3 0.3 1.4 1 0 0 1 1 1 0 WD domain, G-beta repeat WD40 PF00400.32 ETO33724.1 - 1.5e-44 149.1 17.5 7.7e-09 36.1 0.1 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33724.1 - 5.2e-16 58.7 2.3 0.033 14.5 0.0 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33724.1 - 1.1e-09 38.1 4.6 0.0033 16.8 0.0 3.9 3 1 1 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO33724.1 - 1.2e-09 37.6 1.3 0.0078 15.2 0.0 5.0 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33724.1 - 7.7e-08 31.4 2.8 0.22 10.1 0.2 4.4 3 2 2 5 5 5 3 Nucleoporin Nup120/160 Kelch_1 PF01344.25 ETO33724.1 - 2.2e-06 27.2 2.3 0.00052 19.5 0.3 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO33724.1 - 0.00041 20.3 0.7 0.91 9.6 0.4 4.7 5 0 0 5 5 5 1 Kelch motif Cytochrom_D1 PF02239.16 ETO33724.1 - 0.0009 17.9 1.3 0.078 11.5 0.0 3.3 1 1 2 4 4 4 2 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO33724.1 - 0.00095 19.0 3.9 1.1 9.3 0.1 5.3 6 0 0 6 6 6 1 Kelch motif Kelch_6 PF13964.6 ETO33724.1 - 0.0011 19.2 1.4 67 4.0 0.0 5.0 4 0 0 4 4 4 0 Kelch motif Kelch_4 PF13418.6 ETO33724.1 - 0.0014 18.6 0.3 0.34 11.0 0.1 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain VID27 PF08553.10 ETO33724.1 - 0.046 12.8 0.0 0.087 11.9 0.0 1.5 1 0 0 1 1 1 0 VID27 C-terminal WD40-like domain DNA_pol3_delta PF06144.13 ETO33724.1 - 0.073 12.8 0.0 0.19 11.5 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase III, delta subunit Kelch_3 PF13415.6 ETO33724.1 - 0.097 13.0 0.2 6.3 7.2 0.1 3.7 5 0 0 5 5 5 0 Galactose oxidase, central domain PD40 PF07676.12 ETO33724.1 - 4.5 7.3 8.9 17 5.5 0.1 3.9 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO33725.1 - 9.6e-34 114.9 28.6 3.7e-06 27.5 1.0 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33725.1 - 1.8e-13 50.6 1.6 0.0046 17.2 0.0 5.7 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33725.1 - 3.2e-06 26.7 11.4 0.025 13.9 2.7 4.6 2 2 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO33725.1 - 3.5e-06 26.0 9.5 0.19 10.3 0.1 5.0 1 1 4 5 5 5 4 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO33725.1 - 0.41 10.2 7.2 0.35 10.4 4.2 2.4 1 1 0 2 2 2 0 Domain of unknown function (DUF4221) DUF848 PF05852.11 ETO33726.1 - 0.026 14.7 4.1 0.026 14.7 4.1 2.5 1 1 1 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) Cys_knot PF00007.22 ETO33726.1 - 3.7 7.9 12.3 0.42 10.9 5.3 2.4 2 1 1 3 3 3 0 Cystine-knot domain NACHT PF05729.12 ETO33727.1 - 1.2e-12 48.1 0.0 4.7e-12 46.1 0.0 2.1 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO33727.1 - 0.0043 16.3 0.1 0.02 14.1 0.1 2.3 1 1 0 1 1 1 1 NB-ARC domain Mg_chelatase PF01078.21 ETO33727.1 - 0.0074 15.7 0.0 0.013 14.9 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI AAA_16 PF13191.6 ETO33727.1 - 0.037 14.4 0.0 0.13 12.7 0.0 1.9 2 0 0 2 2 2 0 AAA ATPase domain DUF992 PF06186.11 ETO33727.1 - 0.042 13.7 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF992) AAA_22 PF13401.6 ETO33727.1 - 0.07 13.4 0.0 0.55 10.5 0.0 2.4 1 1 0 1 1 1 0 AAA domain Synaptobrevin PF00957.21 ETO33728.1 - 0.32 10.8 3.2 0.23 11.2 0.6 1.9 2 0 0 2 2 2 0 Synaptobrevin WD40 PF00400.32 ETO33729.1 - 1.3e-17 63.8 15.7 5.2e-07 30.3 2.6 4.7 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33729.1 - 7.2e-05 23.0 0.4 4.9 7.5 0.2 3.8 2 2 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33729.1 - 0.00089 18.0 0.2 0.45 9.1 0.1 2.5 1 1 1 3 3 3 2 Nucleoporin Nup120/160 Carboxyl_trans PF01039.22 ETO33731.1 - 2.8e-22 79.0 0.0 3.4e-22 78.7 0.0 1.1 1 0 0 1 1 1 1 Carboxyl transferase domain Ank_2 PF12796.7 ETO33732.1 - 9.3e-09 35.8 7.7 0.00014 22.3 1.4 2.8 1 1 2 3 3 3 3 Ankyrin repeats (3 copies) Ank_4 PF13637.6 ETO33732.1 - 7.3e-06 26.4 0.4 1.7 9.3 0.0 4.1 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO33732.1 - 1.1e-05 25.6 1.1 0.27 11.6 0.0 3.8 3 2 1 4 4 4 2 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO33732.1 - 0.00022 21.4 2.5 7.2 7.5 0.0 4.3 4 0 0 4 4 4 2 Ankyrin repeat CENP-B_dimeris PF09026.10 ETO33732.1 - 0.0086 16.5 1.0 0.016 15.6 1.0 1.5 1 0 0 1 1 1 1 Centromere protein B dimerisation domain Methyltransf_12 PF08242.12 ETO33732.1 - 0.0092 16.7 0.3 0.082 13.7 0.1 2.3 2 0 0 2 2 2 1 Methyltransferase domain PhoQ_Sensor PF08918.10 ETO33732.1 - 0.033 14.1 0.6 0.7 9.7 0.0 2.4 1 1 2 3 3 3 0 PhoQ Sensor RXT2_N PF08595.11 ETO33732.1 - 0.044 13.8 1.8 0.068 13.2 1.8 1.3 1 0 0 1 1 1 0 RXT2-like, N-terminal Thioredoxin_5 PF13743.6 ETO33732.1 - 0.061 13.0 0.4 1.2 8.8 0.1 2.3 2 1 0 2 2 2 0 Thioredoxin FAM176 PF14851.6 ETO33732.1 - 0.062 13.0 0.2 0.088 12.5 0.2 1.2 1 0 0 1 1 1 0 FAM176 family DUF5614 PF18474.1 ETO33732.1 - 0.11 11.9 0.9 3.7 6.8 0.4 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5614) DUF2457 PF10446.9 ETO33732.1 - 0.24 10.5 3.2 0.32 10.1 3.2 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Ank PF00023.30 ETO33732.1 - 0.36 11.4 3.5 16 6.2 0.0 3.6 3 0 0 3 3 3 0 Ankyrin repeat PYST-C1 PF09690.10 ETO33732.1 - 0.43 10.3 13.7 1.1 9.0 13.7 1.7 1 0 0 1 1 1 0 Plasmodium yoelii subtelomeric region (PYST-C1) BTP PF05232.12 ETO33734.1 - 0.2 11.7 0.1 0.2 11.7 0.1 3.2 3 0 0 3 3 3 0 Chlorhexidine efflux transporter Ni_hydr_CYTB PF01292.20 ETO33734.1 - 2.7 7.6 10.1 0.12 11.9 2.9 2.1 1 1 0 2 2 2 0 Prokaryotic cytochrome b561 GOLD_2 PF13897.6 ETO33735.1 - 0.51 10.8 4.7 1.4 9.5 4.7 1.8 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking CobT PF06213.12 ETO33735.1 - 4.1 6.7 18.8 8.1 5.7 18.8 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Pex14_N PF04695.13 ETO33735.1 - 7.8 7.1 12.8 16 6.1 12.8 1.5 1 0 0 1 1 1 0 Peroxisomal membrane anchor protein (Pex14p) conserved region WD40 PF00400.32 ETO33738.1 - 8.6e-39 130.8 31.1 6.2e-07 30.0 1.5 8.2 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33738.1 - 1e-10 41.8 4.1 1.5 9.2 0.0 6.3 5 2 2 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33738.1 - 9.9e-10 37.7 8.2 0.0059 15.3 0.2 4.4 2 1 1 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33738.1 - 6.4e-08 32.3 8.3 0.1 11.9 0.2 4.9 2 2 3 5 5 5 4 WD40-like domain DUF2208 PF09973.9 ETO33740.1 - 0.0015 18.2 3.1 0.0022 17.6 3.1 1.3 1 0 0 1 1 1 1 Predicted membrane protein (DUF2208) Mit_ribos_Mrp51 PF11709.8 ETO33740.1 - 0.4 10.2 10.0 0.72 9.4 10.0 1.4 1 1 0 1 1 1 0 Mitochondrial ribosomal protein subunit FlaC_arch PF05377.11 ETO33740.1 - 4.1 7.9 11.6 1.1 9.7 1.4 2.8 2 1 1 3 3 3 0 Flagella accessory protein C (FlaC) DUF1993 PF09351.10 ETO33742.1 - 0.0057 16.8 1.8 0.023 14.9 1.8 2.0 1 0 0 1 1 1 1 Domain of unknown function (DUF1993) DUF2180 PF09947.9 ETO33743.1 - 0.0038 17.2 2.5 0.0038 17.2 2.5 1.8 1 1 0 1 1 1 1 Uncharacterized protein conserved in archaea (DUF2180) C1_2 PF03107.16 ETO33743.1 - 0.028 14.8 0.1 0.028 14.8 0.1 1.7 2 0 0 2 2 2 0 C1 domain DUF5641 PF18701.1 ETO33743.1 - 0.051 13.7 0.0 0.077 13.2 0.0 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5641) ZZ PF00569.17 ETO33743.1 - 0.23 11.3 5.2 1.4 8.8 5.2 2.2 1 1 0 1 1 1 0 Zinc finger, ZZ type DZR PF12773.7 ETO33743.1 - 0.41 10.7 4.3 0.21 11.6 1.5 1.9 2 0 0 2 2 2 0 Double zinc ribbon zf-Di19 PF05605.12 ETO33743.1 - 0.66 10.3 5.3 0.38 11.1 2.9 1.9 2 0 0 2 2 2 0 Drought induced 19 protein (Di19), zinc-binding Alpha_kinase PF02816.18 ETO33744.1 - 1.2e-48 165.7 0.4 3.5e-48 164.2 0.1 1.9 2 0 0 2 2 2 1 Alpha-kinase family AMP-binding PF00501.28 ETO33745.1 - 1.9e-31 109.1 0.0 3.7e-19 68.6 0.0 2.2 2 0 0 2 2 2 2 AMP-binding enzyme AMP-binding_C PF13193.6 ETO33745.1 - 6.1e-12 46.3 0.0 1.4e-11 45.2 0.0 1.6 1 0 0 1 1 1 1 AMP-binding enzyme C-terminal domain AMP-binding PF00501.28 ETO33746.1 - 3e-36 124.9 0.0 3.3e-36 124.8 0.0 1.0 1 0 0 1 1 1 1 AMP-binding enzyme Alpha_kinase PF02816.18 ETO33747.1 - 3.2e-39 135.0 0.1 2.5e-38 132.1 0.1 2.1 2 0 0 2 2 2 1 Alpha-kinase family FtsJ PF01728.19 ETO33748.1 - 7.6e-55 185.7 0.2 1e-54 185.4 0.2 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase Ribosomal_S17 PF00366.20 ETO33751.1 - 4e-17 62.1 0.0 1.2e-16 60.5 0.0 1.9 1 0 0 1 1 1 1 Ribosomal protein S17 DUF1411 PF07199.11 ETO33751.1 - 0.11 12.2 1.6 0.13 11.9 0.7 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1411) PfkB PF00294.24 ETO33752.1 - 2.6e-13 50.0 1.2 5.6e-12 45.6 1.2 2.0 1 1 0 1 1 1 1 pfkB family carbohydrate kinase PfkB PF00294.24 ETO33753.1 - 7e-12 45.3 0.0 7.8e-12 45.1 0.0 1.2 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Helicase_PWI PF18149.1 ETO33755.1 - 0.043 14.0 1.4 5.7 7.2 0.1 2.2 2 0 0 2 2 2 0 N-terminal helicase PWI domain Syntaxin_2 PF14523.6 ETO33756.1 - 0.00038 20.8 7.6 0.00079 19.8 2.1 2.5 1 1 1 2 2 2 1 Syntaxin-like protein Mitofilin PF09731.9 ETO33756.1 - 0.0022 16.9 7.2 0.0029 16.6 7.2 1.1 1 0 0 1 1 1 1 Mitochondrial inner membrane protein TMF_TATA_bd PF12325.8 ETO33756.1 - 0.0025 18.0 6.1 0.041 14.1 6.1 2.3 1 1 0 1 1 1 1 TATA element modulatory factor 1 TATA binding Bap31_Bap29_C PF18035.1 ETO33756.1 - 0.014 15.4 2.3 0.014 15.4 0.4 2.0 2 0 0 2 2 2 0 Bap31/Bap29 cytoplasmic coiled-coil domain DUF935 PF06074.12 ETO33756.1 - 0.021 13.6 4.1 0.027 13.2 4.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF935) SAM_KSR1 PF13543.6 ETO33756.1 - 0.059 13.5 3.7 4.5 7.4 0.0 2.7 2 1 0 2 2 2 0 SAM like domain present in kinase suppressor RAS 1 GET2 PF08690.10 ETO33756.1 - 0.13 11.9 12.4 0.17 11.5 12.4 1.1 1 0 0 1 1 1 0 GET complex subunit GET2 CdvA PF18822.1 ETO33756.1 - 0.25 11.2 5.2 0.31 10.9 3.6 1.9 1 1 1 2 2 2 0 CdvA-like coiled-coil domain Hamartin PF04388.12 ETO33756.1 - 0.27 9.9 10.9 0.32 9.6 10.9 1.1 1 0 0 1 1 1 0 Hamartin protein FAM76 PF16046.5 ETO33756.1 - 0.54 9.6 6.8 0.71 9.2 6.8 1.1 1 0 0 1 1 1 0 FAM76 protein V_ATPase_I PF01496.19 ETO33756.1 - 0.61 7.9 4.2 0.84 7.5 4.2 1.2 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CENP-H PF05837.12 ETO33756.1 - 0.73 10.3 6.8 1.8 9.0 6.8 1.7 1 0 0 1 1 1 0 Centromere protein H (CENP-H) C2 PF00168.30 ETO33757.1 - 1.9e-24 85.9 0.1 5.8e-24 84.4 0.1 1.9 1 0 0 1 1 1 1 C2 domain Lectin_N PF03954.14 ETO33757.1 - 0.0086 15.8 0.6 0.0086 15.8 0.6 2.2 2 0 0 2 2 2 1 Hepatic lectin, N-terminal domain DUF1664 PF07889.12 ETO33757.1 - 0.047 13.7 1.3 0.047 13.7 1.3 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF1664) DUF4407 PF14362.6 ETO33757.1 - 0.21 10.9 12.7 0.33 10.2 12.6 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Macoilin PF09726.9 ETO33757.1 - 0.24 9.9 19.9 2.5 6.6 19.9 2.0 1 1 0 1 1 1 0 Macoilin family APG6_N PF17675.1 ETO33757.1 - 0.29 11.7 19.1 1.4 9.5 1.0 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region BRE1 PF08647.11 ETO33757.1 - 0.47 10.6 20.3 0.76 9.9 0.3 3.1 2 1 0 2 2 2 0 BRE1 E3 ubiquitin ligase SseC PF04888.12 ETO33757.1 - 0.67 9.5 5.0 0.93 9.0 5.0 1.1 1 0 0 1 1 1 0 Secretion system effector C (SseC) like family DivIC PF04977.15 ETO33757.1 - 0.74 9.6 24.8 0.041 13.7 2.5 3.8 1 1 1 3 3 3 0 Septum formation initiator Cauli_AT PF03233.13 ETO33757.1 - 0.83 9.6 14.7 1.1 9.1 0.3 2.6 2 0 0 2 2 2 0 Aphid transmission protein TMF_TATA_bd PF12325.8 ETO33757.1 - 1.1 9.6 20.0 3 8.1 2.8 2.6 2 1 0 2 2 2 0 TATA element modulatory factor 1 TATA binding Tho2 PF11262.8 ETO33757.1 - 1.2 8.2 17.7 0.52 9.5 2.1 2.3 1 1 1 2 2 2 0 Transcription factor/nuclear export subunit protein 2 DUF4618 PF15397.6 ETO33757.1 - 1.3 8.3 19.3 0.024 14.1 3.7 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4618) TolA_bind_tri PF16331.5 ETO33757.1 - 1.5 8.9 14.4 0.76 9.9 4.2 3.5 2 2 0 2 2 2 0 TolA binding protein trimerisation UPF0449 PF15136.6 ETO33757.1 - 1.6 9.3 10.7 0.2 12.1 1.1 2.5 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 IFT20 PF14931.6 ETO33757.1 - 2.4 8.4 21.2 2.4 8.3 0.5 3.1 2 1 0 3 3 3 0 Intraflagellar transport complex B, subunit 20 DUF4200 PF13863.6 ETO33757.1 - 3.3 8.1 23.0 1.6 9.1 14.2 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF848 PF05852.11 ETO33757.1 - 7.3 6.7 15.8 4.1 7.5 7.2 2.5 2 0 0 2 2 2 0 Gammaherpesvirus protein of unknown function (DUF848) WD40 PF00400.32 ETO33758.1 - 7.2e-19 67.8 17.5 1.1e-07 32.4 2.8 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33758.1 - 1.5e-08 34.8 0.2 0.076 13.3 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33758.1 - 2.5e-08 33.1 1.0 0.17 10.5 0.1 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33758.1 - 0.0021 17.4 2.9 0.14 11.5 1.9 2.7 1 1 1 2 2 2 2 WD40-like domain GH101_N PF17995.1 ETO33758.1 - 0.037 13.7 3.4 0.054 13.1 3.4 1.2 1 0 0 1 1 1 0 Endo-alpha-N-acetylgalactosaminidase N-terminal Kelch_2 PF07646.15 ETO33759.1 - 0.00012 21.9 2.7 0.25 11.4 0.1 4.6 5 1 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO33759.1 - 0.00022 21.2 0.7 0.004 17.1 0.0 2.8 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO33759.1 - 0.00065 19.2 0.3 0.0089 15.6 0.1 2.8 3 0 0 3 3 3 1 Kelch motif TLD PF07534.16 ETO33759.1 - 0.029 14.6 1.0 0.065 13.5 0.2 2.1 1 1 1 2 2 2 0 TLD Kelch_5 PF13854.6 ETO33759.1 - 0.059 13.4 0.2 2.8 8.0 0.1 3.2 3 0 0 3 3 3 0 Kelch motif FDX-ACB PF03147.14 ETO33760.1 - 1.9e-22 79.5 0.2 2.6e-22 79.1 0.2 1.2 1 0 0 1 1 1 1 Ferredoxin-fold anticodon binding domain tRNA-synt_2d PF01409.20 ETO33760.1 - 1.9e-12 47.2 0.0 3.9e-12 46.2 0.0 1.5 2 0 0 2 2 2 1 tRNA synthetases class II core domain (F) DUF3811 PF11656.8 ETO33760.1 - 0.12 12.8 0.0 0.19 12.1 0.0 1.3 1 0 0 1 1 1 0 YjbD family (DUF3811) Sulfotransfer_2 PF03567.14 ETO33761.1 - 0.0021 18.0 2.7 0.0024 17.8 2.7 1.0 1 0 0 1 1 1 1 Sulfotransferase family N6_N4_Mtase PF01555.18 ETO33761.1 - 0.16 11.6 9.0 0.17 11.6 9.0 1.1 1 0 0 1 1 1 0 DNA methylase HHH_9 PF17674.1 ETO33761.1 - 0.73 10.8 4.3 0.3 12.0 1.1 1.8 1 1 1 2 2 2 0 HHH domain O-antigen_lig PF13425.6 ETO33761.1 - 7.7 5.2 9.4 8.3 5.1 9.4 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein KASH_CCD PF14662.6 ETO33762.1 - 5e-05 23.2 8.7 0.0014 18.4 4.7 2.1 2 0 0 2 2 2 2 Coiled-coil region of CCDC155 or KASH Tropomyosin_1 PF12718.7 ETO33762.1 - 0.0029 17.7 4.6 0.0029 17.7 4.6 2.2 2 0 0 2 2 2 1 Tropomyosin like Cnn_1N PF07989.11 ETO33762.1 - 0.02 15.0 2.9 0.02 15.0 2.9 2.5 2 0 0 2 2 2 0 Centrosomin N-terminal motif 1 DUF496 PF04363.12 ETO33762.1 - 0.021 14.8 1.0 0.021 14.8 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF496) Lzipper-MIP1 PF14389.6 ETO33762.1 - 0.022 15.0 0.5 0.022 15.0 0.5 2.6 3 0 0 3 3 3 0 Leucine-zipper of ternary complex factor MIP1 SesA PF17107.5 ETO33762.1 - 0.053 13.7 0.3 0.095 12.9 0.3 1.4 1 0 0 1 1 1 0 N-terminal domain on NACHT_NTPase and P-loop NTPases EMP24_GP25L PF01105.24 ETO33762.1 - 0.078 12.9 4.5 1.6 8.6 0.1 2.1 2 0 0 2 2 2 0 emp24/gp25L/p24 family/GOLD DUF724 PF05266.14 ETO33762.1 - 0.13 12.1 8.7 0.91 9.3 1.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF724) Cep57_CLD PF14073.6 ETO33762.1 - 0.13 12.3 7.8 0.36 10.8 2.5 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of Cep57 Snapin_Pallidin PF14712.6 ETO33762.1 - 0.22 11.9 9.5 0.11 12.9 3.2 2.2 2 0 0 2 2 2 0 Snapin/Pallidin DUF4407 PF14362.6 ETO33762.1 - 0.25 10.6 1.4 0.32 10.3 1.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Fmp27_WPPW PF10359.9 ETO33762.1 - 0.37 9.6 5.3 0.16 10.8 3.1 1.3 1 1 0 1 1 1 0 RNA pol II promoter Fmp27 protein domain DUF2681 PF10883.8 ETO33762.1 - 0.59 10.6 5.5 2.8 8.4 1.5 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) ZapB PF06005.12 ETO33762.1 - 1.4 9.4 12.3 1.2 9.6 5.6 2.4 2 0 0 2 2 2 0 Cell division protein ZapB Csm1_N PF18504.1 ETO33762.1 - 2.3 8.6 9.2 8 6.9 0.5 2.8 2 1 1 3 3 3 0 Csm1 N-terminal domain KLRAQ PF10205.9 ETO33762.1 - 3.2 8.0 9.5 0.51 10.6 4.0 2.0 1 1 0 2 2 2 0 Predicted coiled-coil domain-containing protein TMF_DNA_bd PF12329.8 ETO33762.1 - 3.5 7.7 14.9 4.9 7.2 6.0 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding BST2 PF16716.5 ETO33762.1 - 6.5 7.4 9.3 0.66 10.6 3.7 2.0 2 0 0 2 2 2 0 Bone marrow stromal antigen 2 SUIM_assoc PF16619.5 ETO33763.1 - 0.0039 17.2 11.3 16 5.7 13.2 4.1 3 2 0 3 3 3 2 Unstructured region C-term to UIM in Ataxin3 RsgA_GTPase PF03193.16 ETO33764.1 - 0.00047 20.1 0.7 0.00047 20.1 0.7 3.8 3 1 0 3 3 3 1 RsgA GTPase ABC_tran PF00005.27 ETO33764.1 - 0.00056 20.4 0.0 0.00056 20.4 0.0 3.8 2 1 0 2 2 2 1 ABC transporter MMR_HSR1 PF01926.23 ETO33764.1 - 0.00096 19.2 0.1 0.009 16.1 0.1 2.8 1 0 0 1 1 1 1 50S ribosome-binding GTPase DUF5617 PF18493.1 ETO33764.1 - 0.015 15.4 1.8 0.078 13.1 0.2 3.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5617) AAA_29 PF13555.6 ETO33764.1 - 0.019 14.7 0.1 0.061 13.1 0.1 1.8 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO33764.1 - 0.069 13.4 0.2 0.89 9.8 0.0 3.1 2 0 0 2 2 2 0 AAA domain K_channel_TID PF07941.11 ETO33764.1 - 0.11 13.0 1.0 0.25 11.8 1.0 1.6 1 0 0 1 1 1 0 Potassium channel Kv1.4 tandem inactivation domain DUF4813 PF16072.5 ETO33764.1 - 0.18 11.5 2.5 0.27 10.9 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4813) DUF3439 PF11921.8 ETO33764.1 - 1.4 8.9 9.4 4.3 7.3 9.4 1.8 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AJAP1_PANP_C PF15298.6 ETO33764.1 - 3.5 7.8 10.8 3.5 7.8 7.6 2.4 2 0 0 2 2 2 0 AJAP1/PANP C-terminus V-SNARE_C PF12352.8 ETO33765.1 - 1.3e-07 31.8 0.4 1.3e-07 31.8 0.4 1.9 2 0 0 2 2 2 1 Snare region anchored in the vesicle membrane C-terminus Sec20 PF03908.13 ETO33765.1 - 0.0022 17.9 0.5 0.0035 17.2 0.2 1.5 1 1 0 1 1 1 1 Sec20 ArfA PF03889.13 ETO33765.1 - 0.11 12.0 0.3 0.47 10.0 0.0 2.0 2 0 0 2 2 2 0 Alternative ribosome-rescue factor A HEAT PF02985.22 ETO33766.1 - 2.3e-32 108.2 14.8 0.00025 21.0 0.0 11.2 11 0 0 11 11 11 7 HEAT repeat HEAT_2 PF13646.6 ETO33766.1 - 2.3e-26 92.0 4.1 2.8e-09 37.2 0.1 6.7 4 1 4 8 8 8 5 HEAT repeats Cnd1 PF12717.7 ETO33766.1 - 8.8e-13 48.6 12.5 0.0067 16.5 0.0 7.0 2 1 3 7 7 7 4 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO33766.1 - 6e-11 42.6 4.4 1.6e-05 25.3 0.0 6.1 7 0 0 7 7 6 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO33766.1 - 1.1e-09 38.7 0.8 0.048 14.3 0.0 6.4 3 1 4 7 7 7 3 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO33766.1 - 2.2e-07 30.7 5.4 0.16 11.5 0.0 4.7 2 1 2 4 4 4 3 CLASP N terminal Adaptin_N PF01602.20 ETO33766.1 - 2.8e-06 26.2 12.9 0.017 13.7 0.9 4.9 2 1 2 4 4 4 2 Adaptin N terminal region Cohesin_HEAT PF12765.7 ETO33766.1 - 0.00047 20.4 0.9 1.6 9.1 0.0 4.3 4 0 0 4 4 4 2 HEAT repeat associated with sister chromatid cohesion TAF6_C PF07571.13 ETO33766.1 - 0.0021 18.3 0.2 0.37 11.1 0.0 3.9 3 1 1 4 4 4 1 TAF6 C-terminal HEAT repeat domain DUF4042 PF13251.6 ETO33766.1 - 0.0053 16.5 3.1 2 8.1 0.0 4.0 4 1 1 5 5 5 2 Domain of unknown function (DUF4042) Arm PF00514.23 ETO33766.1 - 0.018 15.0 0.3 2 8.6 0.0 4.0 4 0 0 4 4 4 0 Armadillo/beta-catenin-like repeat RasGEF_N_2 PF14663.6 ETO33766.1 - 0.023 15.1 3.2 24 5.4 0.0 4.8 5 0 0 5 5 5 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Nop52 PF05997.12 ETO33766.1 - 0.062 13.1 0.3 23 4.7 0.0 3.5 3 0 0 3 3 3 0 Nucleolar protein,Nop52 DUF445 PF04286.12 ETO33766.1 - 0.22 11.3 6.4 1.8 8.3 3.5 2.5 1 1 1 2 2 2 0 Protein of unknown function (DUF445) Polyoma_agno PF01736.16 ETO33767.1 - 0.012 15.3 0.1 0.025 14.3 0.1 1.5 1 0 0 1 1 1 0 Polyomavirus agnoprotein Orf78 PF06024.12 ETO33768.1 - 0.0037 17.5 7.1 0.0047 17.2 7.1 1.2 1 0 0 1 1 1 1 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO33768.1 - 0.0094 16.5 6.4 0.012 16.1 6.4 1.2 1 0 0 1 1 1 1 Secretin N-terminal domain DUF4611 PF15387.6 ETO33768.1 - 0.022 14.9 0.2 0.027 14.7 0.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Presenilin PF01080.17 ETO33768.1 - 0.033 13.0 2.0 0.04 12.7 2.0 1.1 1 0 0 1 1 1 0 Presenilin Peroxin-13_N PF04088.13 ETO33768.1 - 0.043 14.1 0.4 0.056 13.7 0.4 1.2 1 0 0 1 1 1 0 Peroxin 13, N-terminal region UPF0239 PF06783.11 ETO33768.1 - 0.22 11.8 0.1 0.22 11.8 0.1 1.5 1 1 1 2 2 2 0 Uncharacterised protein family (UPF0239) Corazonin PF17308.2 ETO33768.1 - 0.42 11.0 10.4 0.53 10.6 10.4 1.1 1 0 0 1 1 1 0 Pro-corazonin ETRAMP PF09716.10 ETO33768.1 - 5.6 7.1 14.7 8.5 6.5 14.7 1.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) Plant_vir_prot PF01307.17 ETO33768.1 - 8.6 6.6 6.9 20 5.5 6.6 1.8 1 1 0 1 1 1 0 Plant viral movement protein Peptidase_M49 PF03571.15 ETO33769.1 - 2.5e-09 36.0 0.2 7.7e-09 34.5 0.1 1.7 1 1 1 2 2 2 1 Peptidase family M49 ELO PF01151.18 ETO33770.1 - 2e-16 60.3 9.3 1.4e-15 57.6 9.0 2.4 1 1 1 2 2 2 1 GNS1/SUR4 family DUF2569 PF10754.9 ETO33770.1 - 0.44 11.0 9.8 0.5 10.8 2.5 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF2569) MIEAP PF16026.5 ETO33771.1 - 5.4e-08 33.3 0.6 1.2e-07 32.1 0.6 1.6 1 0 0 1 1 1 1 Mitochondria-eating protein SpoIIID PF12116.8 ETO33771.1 - 0.045 13.9 0.2 3.9 7.6 0.0 2.8 2 0 0 2 2 2 0 Stage III sporulation protein D ERM PF00769.19 ETO33772.1 - 4.9e-05 23.3 14.9 4.9e-05 23.3 14.9 1.5 2 0 0 2 2 2 1 Ezrin/radixin/moesin family LMBR1 PF04791.16 ETO33772.1 - 0.0011 18.0 13.1 0.0013 17.8 13.1 1.1 1 0 0 1 1 1 1 LMBR1-like membrane protein HOOK PF05622.12 ETO33772.1 - 0.018 13.2 24.8 0.041 12.0 24.8 1.6 1 1 0 1 1 1 0 HOOK protein DUF2551 PF10826.8 ETO33772.1 - 0.019 15.2 0.5 0.049 13.9 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF2551) Pox_A_type_inc PF04508.12 ETO33772.1 - 0.021 14.6 0.3 1.7 8.7 0.0 2.8 2 0 0 2 2 2 0 Viral A-type inclusion protein repeat MPS2 PF17060.5 ETO33772.1 - 0.022 14.0 15.3 0.027 13.8 15.3 1.1 1 0 0 1 1 1 0 Monopolar spindle protein 2 TPR_MLP1_2 PF07926.12 ETO33772.1 - 0.025 14.7 8.1 0.025 14.7 8.1 3.8 2 1 0 3 3 3 0 TPR/MLP1/MLP2-like protein Jnk-SapK_ap_N PF09744.9 ETO33772.1 - 0.031 14.5 19.3 0.04 14.1 2.6 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF2684 PF10885.8 ETO33772.1 - 0.032 14.4 0.1 0.08 13.1 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF2684) Mt_ATP-synt_D PF05873.12 ETO33772.1 - 0.21 11.4 13.5 0.54 10.1 5.2 2.4 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) HrpB7 PF09486.10 ETO33772.1 - 0.22 11.9 17.4 10 6.5 16.9 2.4 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) FlaC_arch PF05377.11 ETO33772.1 - 0.27 11.7 8.1 1.4 9.4 1.4 3.7 2 2 1 3 3 3 0 Flagella accessory protein C (FlaC) MAD PF05557.13 ETO33772.1 - 0.39 9.0 27.3 0.78 8.0 27.3 1.4 1 0 0 1 1 1 0 Mitotic checkpoint protein XhlA PF10779.9 ETO33772.1 - 0.4 10.9 5.7 2.4 8.4 0.3 2.8 2 0 0 2 2 2 0 Haemolysin XhlA APG6_N PF17675.1 ETO33772.1 - 0.43 11.1 19.7 13 6.4 18.0 2.2 2 1 0 2 2 2 0 Apg6 coiled-coil region LRRFIP PF09738.9 ETO33772.1 - 0.52 9.7 22.6 5.5 6.4 22.4 2.3 1 1 0 1 1 1 0 LRRFIP family DUF3584 PF12128.8 ETO33772.1 - 0.62 7.5 21.7 0.99 6.8 21.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) TFIIA PF03153.13 ETO33772.1 - 1.6 8.7 17.9 1.8 8.5 17.9 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit V_ATPase_I PF01496.19 ETO33772.1 - 2.7 5.8 18.4 1.2 7.0 16.2 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family APG17 PF04108.12 ETO33772.1 - 3 6.8 18.9 0.046 12.8 6.8 2.5 2 1 1 3 3 3 0 Autophagy protein Apg17 IFT57 PF10498.9 ETO33772.1 - 3.4 6.5 23.6 2 7.3 6.4 2.3 1 1 0 2 2 2 0 Intra-flagellar transport protein 57 Fib_alpha PF08702.10 ETO33772.1 - 4.2 7.6 22.6 9 6.5 21.1 2.3 1 1 0 1 1 1 0 Fibrinogen alpha/beta chain family Peptidase_S46 PF10459.9 ETO33772.1 - 5.3 5.5 16.7 7 5.2 16.7 1.0 1 0 0 1 1 1 0 Peptidase S46 DLP_helical PF18709.1 ETO33772.1 - 6.3 5.9 19.7 3.9 6.6 8.5 2.4 1 1 0 2 2 2 0 Dynamin-like helical domain DUF3138 PF11336.8 ETO33772.1 - 6.5 5.2 6.4 10 4.6 6.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3138) TRAF_BIRC3_bd PF16673.5 ETO33772.1 - 7.9 6.4 11.0 0.42 10.4 2.1 3.1 2 1 1 3 3 3 0 TNF receptor-associated factor BIRC3 binding domain ABC2_membrane_3 PF12698.7 ETO33773.1 - 0.0046 16.1 1.2 0.0055 15.9 1.2 1.2 1 0 0 1 1 1 1 ABC-2 family transporter protein DUF2207 PF09972.9 ETO33773.1 - 0.0088 14.9 0.5 0.0092 14.8 0.5 1.1 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) vMSA PF00695.19 ETO33773.1 - 0.12 11.5 0.3 0.15 11.1 0.3 1.1 1 0 0 1 1 1 0 Major surface antigen from hepadnavirus Ribosomal_S25 PF03297.15 ETO33773.1 - 0.13 12.4 0.8 3.1 8.1 0.0 2.8 2 1 0 3 3 3 0 S25 ribosomal protein WD40 PF00400.32 ETO33775.1 - 1.9e-35 120.2 26.9 1.7e-05 25.5 0.1 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33775.1 - 2.8e-12 46.7 1.4 0.086 13.1 0.0 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33775.1 - 1.5e-08 33.8 4.1 0.2 10.3 0.1 4.4 3 2 1 4 4 4 4 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO33775.1 - 0.0053 15.6 9.0 0.022 13.5 0.2 4.0 1 1 1 4 4 4 1 Nup133 N terminal like Kelch_6 PF13964.6 ETO33775.1 - 0.26 11.7 10.4 27 5.3 0.3 5.4 5 1 0 5 5 5 0 Kelch motif AAA_12 PF13087.6 ETO33776.1 - 2.6e-11 43.5 0.6 3.3e-10 39.9 0.0 2.6 1 1 1 2 2 2 1 AAA domain Viral_helicase1 PF01443.18 ETO33776.1 - 0.074 12.8 0.8 0.13 12.0 0.1 1.7 2 0 0 2 2 2 0 Viral (Superfamily 1) RNA helicase Suf PF05843.14 ETO33777.1 - 7.4 6.5 16.4 8.6 6.2 16.4 1.1 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) Raftlin PF15250.6 ETO33778.1 - 0.093 11.5 2.2 0.11 11.3 2.2 1.1 1 0 0 1 1 1 0 Raftlin Dsh_C PF12316.8 ETO33778.1 - 0.13 12.7 1.8 0.16 12.4 1.8 1.1 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal Menin PF05053.13 ETO33778.1 - 0.62 8.4 7.2 0.68 8.2 7.2 1.1 1 0 0 1 1 1 0 Menin RbpA PF13397.6 ETO33778.1 - 0.68 10.6 4.3 2.2 8.9 0.4 2.2 1 1 1 2 2 2 0 RNA polymerase-binding protein Ribosomal_L6e PF01159.19 ETO33778.1 - 0.72 10.4 6.0 2.1 8.9 4.4 2.2 1 1 1 2 2 2 0 Ribosomal protein L6e DUF3807 PF12720.7 ETO33778.1 - 4.2 7.6 11.2 6.2 7.0 11.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3807) GREB1 PF15782.5 ETO33778.1 - 4.6 4.2 7.3 4.8 4.2 7.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer VPS13_mid_rpt PF16910.5 ETO33782.1 - 3.6e-12 46.2 1.2 4.3e-10 39.4 2.2 2.6 2 1 0 2 2 2 2 Repeating coiled region of VPS13 WD40 PF00400.32 ETO33783.1 - 1.7e-09 38.1 2.5 0.0011 19.7 0.3 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat VIT1 PF01988.19 ETO33784.1 - 4.1e-55 187.0 0.1 4.1e-55 187.0 0.1 1.9 2 0 0 2 2 2 1 VIT family LrgB PF04172.16 ETO33784.1 - 0.02 14.5 1.0 0.044 13.3 1.0 1.5 1 0 0 1 1 1 0 LrgB-like family 2OG-FeII_Oxy_3 PF13640.6 ETO33788.1 - 4e-12 46.9 0.0 1.4e-11 45.1 0.0 2.0 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily 2OG-FeII_Oxy PF03171.20 ETO33788.1 - 0.0043 17.5 0.1 0.028 14.9 0.0 2.5 3 0 0 3 3 3 1 2OG-Fe(II) oxygenase superfamily VHL PF01847.16 ETO33788.1 - 0.091 12.7 0.1 0.28 11.1 0.1 1.8 1 0 0 1 1 1 0 VHL beta domain 2OG-FeII_Oxy_4 PF13661.6 ETO33788.1 - 0.095 13.4 0.0 0.21 12.2 0.0 1.6 1 0 0 1 1 1 0 2OG-Fe(II) oxygenase superfamily Utp11 PF03998.13 ETO33789.1 - 1.3e-10 41.7 8.8 1.5e-10 41.5 8.8 1.0 1 0 0 1 1 1 1 Utp11 protein CNRIP1 PF15043.6 ETO33790.1 - 0.085 12.4 0.1 0.2 11.2 0.0 1.7 2 0 0 2 2 2 0 CB1 cannabinoid receptor-interacting protein 1 PUB PF09409.10 ETO33791.1 - 1.9e-05 24.5 0.4 4e-05 23.5 0.4 1.5 1 0 0 1 1 1 1 PUB domain VID27_PH PF17747.1 ETO33791.1 - 0.03 14.6 1.3 0.16 12.3 0.1 2.6 2 0 0 2 2 2 0 VID27 PH-like domain Sec2p PF06428.11 ETO33792.1 - 0.0063 16.5 2.5 0.0063 16.5 2.5 2.0 2 0 0 2 2 2 1 GDP/GTP exchange factor Sec2p MCC-bdg_PDZ PF10506.9 ETO33792.1 - 0.027 14.5 0.6 0.057 13.4 0.6 1.5 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome SOGA PF11365.8 ETO33792.1 - 0.079 14.1 6.2 0.1 13.7 5.8 1.4 1 1 0 1 1 1 0 Protein SOGA DUF3450 PF11932.8 ETO33792.1 - 0.26 10.6 9.0 0.31 10.3 8.5 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3450) CemA PF03040.14 ETO33792.1 - 0.47 10.4 3.1 0.55 10.1 3.1 1.1 1 0 0 1 1 1 0 CemA family DUF641 PF04859.12 ETO33792.1 - 1.9 8.8 8.3 7.6 6.9 8.3 1.9 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) SPX PF03105.19 ETO33793.1 - 2.2e-11 44.3 5.3 6.8e-11 42.7 5.4 1.6 1 1 0 1 1 1 1 SPX domain DNApol_Exo PF18136.1 ETO33793.1 - 0.023 13.8 0.6 0.035 13.3 0.6 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain DUF2229 PF09989.9 ETO33793.1 - 0.35 10.5 6.5 0.1 12.3 2.7 1.7 1 1 1 2 2 2 0 CoA enzyme activase uncharacterised domain (DUF2229) WD40 PF00400.32 ETO33794.1 - 5.5e-155 498.6 47.2 1.7e-10 41.3 0.1 16.3 16 0 0 16 16 16 16 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO33794.1 - 1.4e-41 142.6 0.2 0.024 13.6 0.0 15.7 1 1 15 16 16 16 13 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO33794.1 - 2e-37 127.4 12.8 0.018 15.3 0.0 14.8 1 1 14 15 15 15 10 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO33794.1 - 3.9e-17 61.7 27.8 1.9 8.5 0.0 14.4 14 0 0 14 14 14 3 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO33794.1 - 1.9e-13 50.3 1.5 2.4 8.3 0.0 10.9 7 3 6 13 13 13 1 Strictosidine synthase Nup160 PF11715.8 ETO33794.1 - 5.8e-12 45.0 31.3 0.74 8.4 0.0 13.3 4 4 9 15 15 15 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33794.1 - 9.4e-12 44.9 8.7 0.024 14.0 0.1 7.3 3 2 5 9 9 9 4 WD40-like domain SGL PF08450.12 ETO33794.1 - 3.9e-10 39.7 3.4 0.045 13.3 0.0 6.4 1 1 4 6 6 6 2 SMP-30/Gluconolactonase/LRE-like region Cytochrom_D1 PF02239.16 ETO33794.1 - 1.7e-09 36.7 8.5 0.23 9.9 0.0 7.0 1 1 5 8 8 8 4 Cytochrome D1 heme domain DUF1258 PF06869.12 ETO33794.1 - 1.3e-07 31.4 0.8 0.08 12.4 0.0 6.1 5 1 2 7 7 7 2 Protein of unknown function (DUF1258) POLO_box PF00659.18 ETO33794.1 - 9.1e-07 29.0 7.4 28 5.0 0.0 10.1 10 3 1 11 11 11 0 POLO box duplicated region DUF5570 PF17731.1 ETO33794.1 - 6.3e-06 26.3 11.8 27 4.9 0.1 10.3 4 4 8 13 13 13 0 Family of unknown function (DUF5570) DUF3475 PF11961.8 ETO33794.1 - 0.0027 17.8 0.8 15 5.8 0.0 5.0 6 0 0 6 6 5 0 Domain of unknown function (DUF3475) DUF3509 PF12021.8 ETO33794.1 - 0.0032 17.2 0.1 50 3.7 0.0 4.9 4 1 1 5 5 5 0 Protein of unknown function (DUF3509) VID27 PF08553.10 ETO33794.1 - 0.0045 16.1 1.7 22 3.9 0.0 5.3 3 3 3 7 7 7 0 VID27 C-terminal WD40-like domain Resistin PF06954.11 ETO33794.1 - 0.024 15.2 1.7 50 4.5 0.0 6.2 8 2 2 10 10 6 0 Resistin DUF5319 PF17252.2 ETO33794.1 - 0.043 14.1 0.0 56 4.0 0.0 4.9 4 2 4 8 8 7 0 Family of unknown function (DUF5319) Erf4 PF10256.9 ETO33794.1 - 0.045 13.9 0.1 14 5.8 0.0 4.2 4 1 1 5 5 5 0 Golgin subfamily A member 7/ERF4 family Peptidase_C69 PF03577.15 ETO33794.1 - 2.7 6.8 5.4 47 2.7 0.0 4.8 6 0 0 6 6 6 0 Peptidase family C69 TraE PF05309.11 ETO33795.1 - 0.032 13.6 0.1 0.049 13.0 0.1 1.3 1 0 0 1 1 1 0 TraE protein WD40 PF00400.32 ETO33796.1 - 4.3e-35 119.1 8.1 1e-07 32.5 0.0 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33796.1 - 6.6e-15 55.2 0.4 0.0051 17.1 0.0 5.3 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33796.1 - 8.2e-11 41.4 0.1 0.24 10.3 0.0 4.9 2 2 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33796.1 - 1.2e-06 28.1 0.4 0.00039 19.8 0.1 2.5 1 1 0 2 2 2 2 WD40-like domain Cytochrom_D1 PF02239.16 ETO33796.1 - 9e-06 24.5 0.2 0.027 13.0 0.0 2.3 2 0 0 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO33796.1 - 1.1e-05 24.4 7.7 0.02 13.5 0.1 4.0 2 2 2 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO33796.1 - 0.00089 19.1 1.7 2.7 8.0 0.0 4.7 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO33796.1 - 0.0048 16.9 2.0 1.8 8.6 0.0 3.9 3 1 0 3 3 3 1 Ciliary BBSome complex subunit 2, middle region VID27 PF08553.10 ETO33796.1 - 0.0066 15.5 0.4 1.3 8.0 0.0 2.3 2 0 0 2 2 2 2 VID27 C-terminal WD40-like domain Nbas_N PF15492.6 ETO33796.1 - 0.015 14.6 0.2 3.2 7.0 0.0 3.2 3 1 1 4 4 4 0 Neuroblastoma-amplified sequence, N terminal Me-amine-dh_H PF06433.11 ETO33796.1 - 0.017 14.0 0.0 0.075 11.9 0.0 2.0 2 0 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) Mid2 PF04478.12 ETO33796.1 - 0.19 11.5 2.5 1.5 8.6 0.1 3.4 1 1 2 3 3 3 0 Mid2 like cell wall stress sensor DUF2689 PF10894.8 ETO33797.1 - 0.83 9.5 3.8 5.8 6.8 0.3 2.8 2 0 0 2 2 2 0 Protein of unknown function (DUF2689) Chlam_PMP PF02415.17 ETO33798.1 - 3.5 8.3 28.7 0.3 11.6 0.4 8.5 9 0 0 9 9 9 0 Chlamydia polymorphic membrane protein (Chlamydia_PMP) repeat SUIM_assoc PF16619.5 ETO33798.1 - 3.8 7.7 8.5 0.37 10.9 3.0 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 Pkinase PF00069.25 ETO33799.1 - 8.6e-58 195.8 0.4 6.9e-52 176.4 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33799.1 - 1.5e-28 99.8 0.1 5.2e-26 91.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kinase-like PF14531.6 ETO33799.1 - 0.002 17.5 0.0 0.03 13.7 0.0 2.2 2 0 0 2 2 2 1 Kinase-like KA1 PF02149.19 ETO33799.1 - 0.0089 15.8 0.1 0.018 14.9 0.1 1.4 1 0 0 1 1 1 1 Kinase associated domain 1 Haspin_kinase PF12330.8 ETO33799.1 - 0.015 14.2 0.0 0.023 13.6 0.0 1.3 1 0 0 1 1 1 0 Haspin like kinase domain Pkinase_fungal PF17667.1 ETO33799.1 - 0.03 13.1 0.6 0.077 11.7 0.0 1.8 2 0 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 ETO33799.1 - 0.032 13.8 0.1 0.073 12.6 0.1 1.5 1 0 0 1 1 1 0 Choline/ethanolamine kinase APH PF01636.23 ETO33799.1 - 0.048 13.6 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Phosphotransferase enzyme family WD40 PF00400.32 ETO33803.1 - 3.6e-26 90.9 13.8 6.3e-07 30.0 1.2 5.2 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33803.1 - 1.2e-08 35.1 0.5 0.02 15.2 0.0 4.2 4 0 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain DUF4979 PF16351.5 ETO33803.1 - 0.00099 19.4 5.2 0.28 11.4 0.1 3.6 1 1 2 4 4 4 2 Domain of unknown function (DUF4979) Nup160 PF11715.8 ETO33803.1 - 0.0016 17.2 1.5 3.3 6.3 0.1 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 PUB PF09409.10 ETO33804.1 - 6.9e-05 22.7 2.8 0.00024 21.0 2.8 1.8 1 1 0 1 1 1 1 PUB domain CW_binding_1 PF01473.20 ETO33804.1 - 0.31 11.4 5.3 1.1 9.7 5.3 2.0 1 0 0 1 1 1 0 Putative cell wall binding repeat SDA1 PF05285.12 ETO33807.1 - 0.0013 18.2 11.4 0.0013 18.2 11.4 1.4 2 0 0 2 2 2 1 SDA1 BUD22 PF09073.10 ETO33807.1 - 0.0039 16.6 9.9 0.0039 16.6 9.9 1.5 2 0 0 2 2 2 1 BUD22 CDC45 PF02724.14 ETO33807.1 - 0.027 12.8 10.6 0.038 12.3 10.6 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF2151 PF10221.9 ETO33807.1 - 0.064 11.8 6.3 0.1 11.2 6.3 1.2 1 0 0 1 1 1 0 Cell cycle and development regulator GCIP PF13324.6 ETO33807.1 - 0.12 11.9 9.3 0.2 11.2 9.3 1.3 1 0 0 1 1 1 0 Grap2 and cyclin-D-interacting DUF3123 PF11321.8 ETO33807.1 - 0.23 12.1 1.7 1.3 9.7 0.0 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3123) RXT2_N PF08595.11 ETO33807.1 - 0.39 10.7 12.0 0.89 9.6 12.0 1.6 1 0 0 1 1 1 0 RXT2-like, N-terminal PI3K_1B_p101 PF10486.9 ETO33807.1 - 0.47 8.2 4.3 0.6 7.8 4.3 1.2 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Zip PF02535.22 ETO33807.1 - 0.73 9.0 4.5 1.3 8.2 4.5 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter Nop14 PF04147.12 ETO33807.1 - 3.1 5.9 22.7 5.3 5.1 22.7 1.3 1 0 0 1 1 1 0 Nop14-like family DUF4407 PF14362.6 ETO33807.1 - 4.6 6.5 5.0 8.7 5.6 5.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Kelch_6 PF13964.6 ETO33808.1 - 0.00067 19.9 2.0 0.94 9.9 0.0 3.8 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO33808.1 - 0.013 15.0 0.1 13 5.5 0.0 3.3 3 0 0 3 3 3 0 Kelch motif DKNYY PF13644.6 ETO33808.1 - 0.014 16.2 3.4 0.014 16.2 3.4 1.6 2 0 0 2 2 2 0 DKNYY family ANT PF03374.14 ETO33809.1 - 0.05 13.9 2.2 0.14 12.5 0.2 2.3 2 0 0 2 2 2 0 Phage antirepressor protein KilAC domain Nucleoporin_N PF08801.11 ETO33810.1 - 4.3e-31 108.1 0.2 1e-25 90.4 0.2 2.0 1 1 1 2 2 2 2 Nup133 N terminal like NodA PF02474.15 ETO33810.1 - 0.07 12.8 0.0 0.13 11.9 0.0 1.4 1 0 0 1 1 1 0 Nodulation protein A (NodA) Tubulin PF00091.25 ETO33811.1 - 7.8e-63 212.2 0.1 1.4e-62 211.4 0.1 1.4 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO33811.1 - 1.7e-36 125.1 0.0 2.8e-36 124.4 0.0 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO33811.1 - 0.044 13.0 0.0 0.077 12.2 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Ribosomal_L13 PF00572.18 ETO33812.1 - 1e-37 129.1 0.1 1.9e-37 128.3 0.1 1.5 1 1 0 1 1 1 1 Ribosomal protein L13 CLASP_N PF12348.8 ETO33814.1 - 0.013 15.1 0.1 0.019 14.5 0.1 1.2 1 0 0 1 1 1 0 CLASP N terminal DUF4834 PF16118.5 ETO33815.1 - 0.00077 20.4 1.7 0.011 16.7 1.7 2.1 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) DUF5527 PF17665.1 ETO33815.1 - 0.0044 16.6 0.0 0.0083 15.7 0.0 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5527) Zip PF02535.22 ETO33815.1 - 0.012 14.8 0.1 0.017 14.4 0.1 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Nucleoside_tran PF01733.18 ETO33815.1 - 0.021 14.2 0.1 0.033 13.6 0.1 1.5 1 1 0 1 1 1 0 Nucleoside transporter Cadherin_C_2 PF16492.5 ETO33815.1 - 0.026 15.3 0.0 0.037 14.8 0.0 1.4 1 1 0 1 1 1 0 Cadherin cytoplasmic C-terminal SID-1_RNA_chan PF13965.6 ETO33815.1 - 0.036 12.5 0.4 0.049 12.0 0.4 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Comm PF15957.5 ETO33815.1 - 0.045 14.1 0.3 0.065 13.6 0.4 1.4 1 1 0 1 1 1 0 Commissureless FAM176 PF14851.6 ETO33815.1 - 0.078 12.6 0.2 0.078 12.6 0.2 2.1 1 1 1 2 2 2 0 FAM176 family Ctr PF04145.15 ETO33815.1 - 0.095 13.3 0.1 0.15 12.6 0.1 1.3 1 1 0 1 1 1 0 Ctr copper transporter family SpoIIIAH PF12685.7 ETO33815.1 - 0.32 10.8 10.0 2.3 8.0 10.0 1.9 1 1 0 1 1 1 0 SpoIIIAH-like protein OAD_gamma PF04277.13 ETO33815.1 - 1.7 9.3 4.8 13 6.4 4.8 2.3 1 1 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain TRAP_alpha PF03896.16 ETO33815.1 - 9 5.4 10.9 1 8.5 4.6 2.0 1 1 1 2 2 2 0 Translocon-associated protein (TRAP), alpha subunit WD40 PF00400.32 ETO33816.1 - 3.5e-20 71.9 9.5 0.00063 20.5 0.0 6.8 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33816.1 - 0.0013 18.9 1.4 24 5.3 0.0 4.6 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33816.1 - 0.062 11.9 0.0 3.2 6.3 0.0 2.6 3 0 0 3 3 3 0 Nucleoporin Nup120/160 Rav1p_C PF12234.8 ETO33816.1 - 0.081 11.3 0.1 0.14 10.6 0.1 1.3 1 0 0 1 1 1 0 RAVE protein 1 C terminal DUF3145 PF11343.8 ETO33817.1 - 0.1 12.2 0.1 0.16 11.6 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3145) OATP PF03137.20 ETO33817.1 - 0.13 10.5 6.5 1.2 7.4 0.2 2.0 2 0 0 2 2 2 0 Organic Anion Transporter Polypeptide (OATP) family DUF1943 PF09172.11 ETO33817.1 - 0.28 10.4 8.8 1 8.5 6.4 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF1943) Conotoxin PF02950.17 ETO33817.1 - 1.2 10.2 4.5 9.4 7.3 0.1 2.5 2 0 0 2 2 2 0 Conotoxin Peptidase_S49_N PF08496.10 ETO33817.1 - 4.2 7.4 10.7 8.4 6.4 5.3 2.3 2 0 0 2 2 2 0 Peptidase family S49 N-terminal Josephin PF02099.17 ETO33818.1 - 7e-07 29.5 1.1 2.4e-06 27.7 0.0 2.5 3 0 0 3 3 3 1 Josephin RAP80_UIM PF18282.1 ETO33818.1 - 0.7 9.7 5.7 1.8 8.4 0.2 2.8 3 0 0 3 3 3 0 RAP80 N-terminal ubiquitin interaction motif THAP PF05485.12 ETO33822.1 - 0.057 14.4 0.5 0.057 14.4 0.5 3.6 4 0 0 4 4 4 0 THAP domain TPR_2 PF07719.17 ETO33823.1 - 1.7e-11 43.3 1.8 0.0037 17.3 0.1 3.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33823.1 - 5.9e-11 41.7 7.3 1.2e-05 24.9 0.0 3.8 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33823.1 - 9.7e-09 35.0 0.4 0.034 14.5 0.0 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33823.1 - 0.0003 20.8 1.1 0.61 10.4 0.1 3.0 3 0 0 3 3 3 2 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO33823.1 - 0.00045 20.2 1.5 15 5.8 0.0 4.0 4 0 0 4 4 4 2 Fis1 C-terminal tetratricopeptide repeat TPR_19 PF14559.6 ETO33823.1 - 0.0027 18.2 0.0 0.86 10.2 0.0 3.0 2 1 1 3 3 3 1 Tetratricopeptide repeat DUF3808 PF10300.9 ETO33823.1 - 0.015 14.0 0.4 0.018 13.8 0.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) TPR_11 PF13414.6 ETO33823.1 - 1.3 8.8 4.9 23 4.8 0.1 4.1 4 2 1 5 5 5 0 TPR repeat CAP_GLY PF01302.25 ETO33824.1 - 2.6e-165 536.7 50.7 1.2e-18 66.9 0.9 12.5 12 0 0 12 12 12 12 CAP-Gly domain YajC PF02699.15 ETO33824.1 - 0.0012 18.7 31.0 0.57 10.1 0.1 11.0 12 0 0 12 12 12 2 Preprotein translocase subunit Amidase_6 PF12671.7 ETO33824.1 - 0.0052 16.9 3.4 0.064 13.4 0.1 3.3 4 0 0 4 4 4 1 Putative amidase domain Hint_2 PF13403.6 ETO33824.1 - 0.032 14.5 8.8 36 4.6 0.0 7.2 9 0 0 9 9 9 0 Hint domain MS_channel PF00924.18 ETO33824.1 - 3.3 7.2 6.8 6.5 6.2 0.1 3.7 4 0 0 4 4 4 0 Mechanosensitive ion channel WD40 PF00400.32 ETO33825.1 - 2.6e-53 176.8 22.7 6.6e-09 36.3 1.1 7.1 6 1 1 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33825.1 - 4.2e-19 68.6 0.9 0.00043 20.5 0.0 6.0 1 1 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33825.1 - 2.1e-14 53.3 0.8 0.22 10.4 0.0 6.9 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO33825.1 - 1.1e-08 35.2 1.3 0.0085 16.0 0.0 3.8 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO33825.1 - 1.1e-08 34.2 8.2 0.056 12.1 0.0 5.2 1 1 5 6 6 6 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33825.1 - 4.4e-06 26.2 0.7 0.061 12.7 0.1 2.7 1 1 2 3 3 3 3 WD40-like domain Coatomer_WDAD PF04053.14 ETO33825.1 - 5.5e-05 22.4 0.8 0.00011 21.5 0.9 1.5 1 1 0 1 1 1 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO33825.1 - 0.00018 20.2 0.2 0.048 12.2 0.0 2.8 1 1 1 2 2 2 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO33825.1 - 0.0013 18.8 0.7 0.39 10.8 0.0 3.7 2 1 2 4 4 4 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO33825.1 - 0.0089 15.9 9.9 12 6.0 0.0 5.6 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO33825.1 - 0.009 15.0 1.8 1.1 8.1 0.1 3.6 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain Str_synth PF03088.16 ETO33825.1 - 0.044 13.9 2.0 6.1 7.0 0.0 4.2 5 1 1 6 6 6 0 Strictosidine synthase Proteasome_A_N PF10584.9 ETO33825.1 - 0.21 11.3 8.3 8 6.2 0.0 4.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Kelch_4 PF13418.6 ETO33826.1 - 8e-05 22.6 5.3 0.00011 22.2 0.5 2.4 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO33826.1 - 0.00023 21.3 4.1 0.015 15.6 0.3 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO33826.1 - 0.0039 17.1 4.1 0.049 13.6 0.8 2.6 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO33826.1 - 0.056 13.0 1.6 1.6 8.4 0.0 2.8 3 0 0 3 3 3 0 Kelch motif Kelch_3 PF13415.6 ETO33826.1 - 0.58 10.5 3.3 1 9.7 0.1 2.2 1 1 1 2 2 2 0 Galactose oxidase, central domain zf-C3HC4_2 PF13923.6 ETO33827.1 - 0.12 12.2 0.8 0.29 11.0 0.8 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_L6e_N PF03868.15 ETO33829.1 - 7.7 6.8 7.8 1.8 8.9 0.1 3.1 3 0 0 3 3 3 0 Ribosomal protein L6, N-terminal domain Ish1 PF10281.9 ETO33829.1 - 9 6.7 7.9 1e+02 3.3 0.0 5.1 6 1 0 6 6 6 0 Putative stress-responsive nuclear envelope protein DUF2670 PF10875.8 ETO33830.1 - 0.11 12.7 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2670) AnmK PF03702.14 ETO33830.1 - 0.23 10.5 0.0 0.29 10.2 0.0 1.1 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase Hydrolase_4 PF12146.8 ETO33831.1 - 2.6e-45 154.6 2.0 1.5e-27 96.4 0.0 2.1 1 1 0 2 2 2 2 Serine aminopeptidase, S33 Abhydrolase_1 PF00561.20 ETO33831.1 - 2.7e-09 37.0 2.4 0.0015 18.2 1.9 2.2 2 0 0 2 2 2 2 alpha/beta hydrolase fold Abhydrolase_6 PF12697.7 ETO33831.1 - 3.9e-06 27.6 0.0 8.8e-06 26.5 0.0 1.5 1 1 0 1 1 1 1 Alpha/beta hydrolase family Peptidase_S15 PF02129.18 ETO33831.1 - 0.00054 19.6 0.0 0.79 9.3 0.0 2.2 2 0 0 2 2 2 2 X-Pro dipeptidyl-peptidase (S15 family) Peptidase_S9 PF00326.21 ETO33831.1 - 0.00098 18.6 0.5 0.025 14.1 0.0 2.2 2 0 0 2 2 2 1 Prolyl oligopeptidase family FSH1 PF03959.13 ETO33831.1 - 0.0079 15.9 0.0 0.014 15.1 0.0 1.3 1 0 0 1 1 1 1 Serine hydrolase (FSH1) DLH PF01738.18 ETO33831.1 - 0.037 13.6 0.0 0.14 11.7 0.0 1.8 2 0 0 2 2 2 0 Dienelactone hydrolase family zf-MYND PF01753.18 ETO33832.1 - 6.7e-10 38.9 21.0 1.1e-09 38.2 21.0 1.4 1 0 0 1 1 1 1 MYND finger zf-HIT PF04438.16 ETO33832.1 - 0.38 10.7 13.5 0.89 9.5 13.5 1.7 1 0 0 1 1 1 0 HIT zinc finger Gln-synt_C-ter PF18318.1 ETO33835.1 - 0.0088 15.9 1.3 0.015 15.2 1.3 1.3 1 0 0 1 1 1 1 Glutamine synthetase C-terminal domain SWI-SNF_Ssr4 PF08549.10 ETO33835.1 - 0.027 13.1 1.1 0.033 12.8 1.1 1.1 1 0 0 1 1 1 0 Fungal domain of unknown function (DUF1750) Herpes_DNAp_acc PF04929.12 ETO33835.1 - 4.9 6.0 9.4 6.4 5.6 9.4 1.1 1 0 0 1 1 1 0 Herpes DNA replication accessory factor DUF3439 PF11921.8 ETO33836.1 - 0.00062 19.7 7.0 0.0013 18.7 7.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF3439) SSP160 PF06933.11 ETO33836.1 - 0.012 13.8 9.3 0.016 13.4 9.3 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 FSA_C PF10479.9 ETO33836.1 - 0.018 13.2 4.6 0.025 12.7 4.6 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus PCI PF01399.27 ETO33836.1 - 0.028 14.9 0.7 0.087 13.3 0.0 2.1 2 1 0 2 2 2 0 PCI domain TPR_2 PF07719.17 ETO33836.1 - 0.045 13.9 0.5 0.59 10.4 0.0 3.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF4805 PF16063.5 ETO33836.1 - 0.48 9.7 4.2 0.92 8.8 4.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4805) Sporozoite_P67 PF05642.11 ETO33836.1 - 0.55 8.3 6.9 0.78 7.7 6.9 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen DUF4512 PF14975.6 ETO33836.1 - 2.3 9.1 4.3 4.3 8.2 4.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) NST1 PF13945.6 ETO33836.1 - 9.4 6.3 9.7 16 5.5 9.7 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator TRM PF02005.16 ETO33837.1 - 6.2e-19 68.4 0.4 1.4e-17 64.0 0.2 2.1 2 0 0 2 2 2 1 N2,N2-dimethylguanosine tRNA methyltransferase DUF5523 PF17661.1 ETO33837.1 - 0.00057 19.7 8.3 0.00077 19.2 8.3 1.1 1 0 0 1 1 1 1 Family of unknown function (DUF5523) NARP1 PF12569.8 ETO33837.1 - 0.0018 17.3 5.9 0.0023 16.9 5.9 1.1 1 0 0 1 1 1 1 NMDA receptor-regulated protein 1 AP3D1 PF06375.11 ETO33837.1 - 0.0038 17.5 9.8 0.0053 17.0 9.8 1.2 1 0 0 1 1 1 1 AP-3 complex subunit delta-1 Connexin PF00029.19 ETO33837.1 - 0.0069 16.2 2.9 0.014 15.2 2.9 1.5 1 0 0 1 1 1 1 Connexin PPL5 PF18168.1 ETO33837.1 - 0.033 13.5 4.7 0.047 13.0 4.7 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF3464 PF11947.8 ETO33837.1 - 0.043 13.6 0.8 0.063 13.0 0.8 1.3 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 TRAP_alpha PF03896.16 ETO33837.1 - 0.057 12.6 0.1 0.082 12.1 0.1 1.2 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit DUF913 PF06025.12 ETO33837.1 - 0.061 12.3 0.2 0.075 12.0 0.2 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 ETO33837.1 - 0.066 11.5 3.2 0.079 11.2 3.2 1.1 1 0 0 1 1 1 0 CDC45-like protein DDHD PF02862.17 ETO33837.1 - 0.089 12.9 0.2 0.094 12.9 0.2 1.2 1 0 0 1 1 1 0 DDHD domain Presenilin PF01080.17 ETO33837.1 - 0.14 10.9 2.0 0.21 10.3 2.0 1.3 1 0 0 1 1 1 0 Presenilin Peptidase_S49_N PF08496.10 ETO33837.1 - 0.17 11.9 4.3 0.27 11.3 4.3 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PHC2_SAM_assoc PF16616.5 ETO33837.1 - 0.39 11.6 7.2 0.72 10.7 7.2 1.4 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 V_ATPase_I PF01496.19 ETO33837.1 - 0.42 8.5 5.9 0.71 7.7 5.9 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF4820 PF16091.5 ETO33837.1 - 0.54 9.6 6.3 0.85 8.9 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) FAM176 PF14851.6 ETO33837.1 - 0.56 9.9 7.9 0.91 9.2 7.9 1.3 1 0 0 1 1 1 0 FAM176 family Afi1 PF07792.12 ETO33837.1 - 0.68 10.4 8.5 1.1 9.7 8.5 1.3 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Nucleo_P87 PF07267.11 ETO33837.1 - 0.9 8.3 6.4 1.2 7.9 6.4 1.1 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 DUF1943 PF09172.11 ETO33837.1 - 1.3 8.2 6.7 2 7.6 6.7 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1943) Sec62 PF03839.16 ETO33837.1 - 1.4 8.4 8.8 2.3 7.7 8.8 1.3 1 0 0 1 1 1 0 Translocation protein Sec62 Paramyxo_ncap PF00973.19 ETO33837.1 - 2.2 7.1 3.8 2.9 6.7 3.8 1.1 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein DUF2956 PF11169.8 ETO33837.1 - 3.1 8.0 10.4 6 7.1 10.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2956) RNA_pol_Rpc4 PF05132.14 ETO33837.1 - 3.7 8.0 7.2 6.3 7.2 7.2 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 zf-CHY PF05495.12 ETO33837.1 - 4.6 7.8 11.9 0.3 11.6 3.9 2.4 2 1 0 2 2 2 0 CHY zinc finger Pox_Ag35 PF03286.14 ETO33837.1 - 4.9 6.9 12.8 7.2 6.4 12.8 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein SHR3_chaperone PF08229.11 ETO33837.1 - 7.3 5.5 8.3 77 2.2 8.3 2.3 1 1 0 1 1 1 0 ER membrane protein SH3 RNA_pol_Rpc4 PF05132.14 ETO33838.1 - 0.00096 19.6 4.0 0.00099 19.6 4.0 1.1 1 0 0 1 1 1 1 RNA polymerase III RPC4 Afi1 PF07792.12 ETO33838.1 - 0.0079 16.7 5.2 0.0079 16.7 5.2 1.1 1 0 0 1 1 1 1 Docking domain of Afi1 for Arf3 in vesicle trafficking SID-1_RNA_chan PF13965.6 ETO33838.1 - 0.11 10.9 0.2 0.1 11.0 0.2 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Connexin PF00029.19 ETO33838.1 - 0.26 11.0 5.9 0.26 11.0 5.9 1.2 1 0 0 1 1 1 0 Connexin Zip PF02535.22 ETO33838.1 - 0.29 10.3 5.4 0.3 10.3 5.4 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter DUF913 PF06025.12 ETO33838.1 - 0.34 9.8 6.6 0.36 9.7 6.6 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CSG2 PF16965.5 ETO33838.1 - 0.57 9.1 0.8 0.61 9.0 0.8 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator OATP PF03137.20 ETO33838.1 - 1.2 7.4 2.4 1.2 7.3 2.4 1.1 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family V_ATPase_I PF01496.19 ETO33838.1 - 1.2 6.9 12.6 1.4 6.7 12.6 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family CLN3 PF02487.17 ETO33838.1 - 2.9 6.8 4.2 3.1 6.8 4.2 1.1 1 0 0 1 1 1 0 CLN3 protein Vfa1 PF08432.10 ETO33838.1 - 5.4 7.3 25.4 6.7 7.0 25.4 1.1 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Cons_hypoth698 PF03601.14 ETO33839.1 - 0.021 13.7 0.0 0.031 13.2 0.0 1.3 1 0 0 1 1 1 0 Conserved hypothetical protein 698 Kelch_6 PF13964.6 ETO33840.1 - 5.8e-09 35.9 0.2 0.31 11.4 0.1 4.2 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO33840.1 - 2.3e-08 33.7 0.2 0.0086 16.0 0.0 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO33840.1 - 2.5e-07 30.2 0.5 0.03 13.9 0.0 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO33840.1 - 3.7e-07 30.0 3.8 1.6 8.8 0.1 5.0 5 0 0 5 5 5 3 Kelch motif Kelch_4 PF13418.6 ETO33840.1 - 3.9e-07 30.0 0.0 0.00016 21.6 0.0 2.8 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO33840.1 - 0.053 13.8 0.1 21 5.5 0.0 4.2 5 0 0 5 5 5 0 Galactose oxidase, central domain Hph PF13694.6 ETO33840.1 - 0.057 13.7 0.3 0.11 12.8 0.3 1.4 1 0 0 1 1 1 0 Sec63/Sec62 complex-interacting family Hexapep_2 PF14602.6 ETO33840.1 - 0.22 11.3 1.0 0.5 10.2 1.0 1.6 1 0 0 1 1 1 0 Hexapeptide repeat of succinyl-transferase DUF4175 PF13779.6 ETO33841.1 - 0.072 11.0 5.0 0.1 10.5 5.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) DUF4639 PF15479.6 ETO33841.1 - 0.12 11.3 1.9 0.17 10.8 1.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4639) Ctr PF04145.15 ETO33841.1 - 0.22 12.1 1.1 0.62 10.7 1.1 1.7 1 0 0 1 1 1 0 Ctr copper transporter family Zip PF02535.22 ETO33841.1 - 0.36 10.0 3.4 0.5 9.5 3.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO33841.1 - 2.1 7.0 7.6 3.3 6.4 7.6 1.3 1 0 0 1 1 1 0 Presenilin HAD_2 PF13419.6 ETO33842.1 - 0.00013 22.1 0.0 0.00029 21.0 0.0 1.5 1 1 0 1 1 1 1 Haloacid dehalogenase-like hydrolase Hydrolase_like PF13242.6 ETO33842.1 - 0.0031 17.5 0.0 0.0054 16.8 0.0 1.4 1 0 0 1 1 1 1 HAD-hyrolase-like UPF0270 PF06794.12 ETO33842.1 - 0.093 12.8 0.0 0.12 12.4 0.0 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0270) BSMAP PF12280.8 ETO33843.1 - 1.6 8.9 9.6 0.07 13.3 2.3 2.2 1 1 1 2 2 2 0 Brain specific membrane anchored protein DUF4833 PF16117.5 ETO33844.1 - 1.4e-42 145.0 0.7 1.8e-42 144.6 0.7 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4833) Rhomboid PF01694.22 ETO33845.1 - 0.0087 16.1 10.3 0.02 14.9 3.9 2.2 1 1 1 2 2 2 2 Rhomboid family MgtC PF02308.16 ETO33845.1 - 4.2 7.7 12.1 0.62 10.4 0.5 2.8 2 1 1 3 3 3 0 MgtC family BBP1_N PF15271.6 ETO33846.1 - 0.089 13.6 1.7 1.9 9.3 0.1 2.9 3 0 0 3 3 3 0 Spindle pole body component BBP1, Mps2-binding protein RHD3 PF05879.12 ETO33847.1 - 0.0006 18.1 0.1 0.00095 17.4 0.1 1.3 1 0 0 1 1 1 1 Root hair defective 3 GTP-binding protein (RHD3) TetR_C_5 PF08360.11 ETO33847.1 - 0.012 15.8 0.1 0.032 14.4 0.1 1.8 1 0 0 1 1 1 0 QacR-like protein, C-terminal region DUF2689 PF10894.8 ETO33847.1 - 0.089 12.6 0.1 0.4 10.5 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2689) WD40 PF00400.32 ETO33848.1 - 5.2e-47 156.9 14.2 3.1e-09 37.3 0.2 6.9 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33848.1 - 1.2e-21 76.8 4.6 0.0023 18.2 0.0 7.6 2 1 4 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33848.1 - 4.1e-12 45.7 3.0 0.19 10.7 0.0 6.3 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33848.1 - 2e-06 27.4 2.3 0.028 13.8 0.1 3.8 2 2 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO33848.1 - 8e-06 24.8 4.3 0.01 14.5 2.0 4.3 1 1 1 2 2 2 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO33848.1 - 0.00038 19.1 0.4 0.021 13.4 0.0 2.5 1 1 0 2 2 2 1 Cytochrome D1 heme domain GTP-bdg_M PF16360.5 ETO33848.1 - 0.036 14.6 0.5 0.11 13.1 0.5 1.8 2 0 0 2 2 2 0 GTP-binding GTPase Middle Region PD40 PF07676.12 ETO33848.1 - 0.083 12.9 1.3 1e+02 3.0 0.0 4.6 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO33848.1 - 0.2 11.4 3.5 16 5.3 0.0 4.0 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature DUF5570 PF17731.1 ETO33848.1 - 0.29 11.2 2.9 14 5.8 0.0 4.1 2 1 4 6 6 6 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO33849.1 - 2.7e-55 183.1 9.2 2.4e-10 40.8 0.3 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33849.1 - 8.9e-24 83.6 0.7 0.0018 18.5 0.0 6.3 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33849.1 - 2.2e-09 36.7 0.4 0.032 13.2 0.0 5.1 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO33849.1 - 4.4e-09 36.5 0.1 7.2e-06 26.0 0.0 3.8 2 1 2 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO33849.1 - 7e-07 28.3 0.5 0.098 11.3 0.0 4.1 1 1 1 4 4 4 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO33849.1 - 1.2e-06 28.2 4.6 0.71 9.9 0.1 5.5 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO33849.1 - 1.5e-05 24.5 1.0 0.11 11.8 0.0 3.7 1 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO33849.1 - 2.1e-05 23.3 0.4 0.015 13.9 0.0 3.2 2 1 1 3 3 3 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO33849.1 - 0.0001 22.4 0.9 3.6 7.7 0.0 4.8 2 1 3 5 5 5 1 Family of unknown function (DUF5570) nos_propeller PF18764.1 ETO33849.1 - 0.0021 17.9 0.1 5 7.1 0.0 3.6 4 0 0 4 4 4 1 Nitrous oxide reductase propeller repeat DUF5122 PF17164.4 ETO33849.1 - 0.15 12.4 0.4 31 5.0 0.0 3.5 4 0 0 4 4 3 0 Domain of unknown function (DUF5122) beta-propeller Proteasome_A_N PF10584.9 ETO33849.1 - 0.33 10.7 2.2 48 3.8 0.3 3.8 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF4746 PF15928.5 ETO33853.1 - 0.045 13.2 7.9 0.06 12.8 7.9 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) WDCP PF15390.6 ETO33853.1 - 0.75 8.1 9.1 0.92 7.8 9.1 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family ALMT PF11744.8 ETO33853.1 - 2.5 6.9 7.6 2.8 6.7 7.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter Hydin_ADK PF17213.3 ETO33853.1 - 7.9 6.7 7.7 11 6.2 7.7 1.3 1 0 0 1 1 1 0 Hydin Adenylate kinase-like domain Presenilin PF01080.17 ETO33853.1 - 8.3 5.1 6.5 9.4 4.9 6.5 1.1 1 0 0 1 1 1 0 Presenilin N6-adenineMlase PF10237.9 ETO33854.1 - 2.2e-33 115.4 4.1 2.8e-33 115.0 4.1 1.1 1 0 0 1 1 1 1 Probable N6-adenine methyltransferase AAA PF00004.29 ETO33855.1 - 2.7e-06 27.9 0.1 5.6e-06 26.8 0.1 1.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA PF00004.29 ETO33856.1 - 1.7e-14 54.4 0.0 3.1e-14 53.5 0.0 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_16 PF13191.6 ETO33856.1 - 3.7e-06 27.4 0.0 6e-06 26.8 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO33856.1 - 4.6e-06 27.0 0.0 9.2e-06 26.0 0.0 1.5 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO33856.1 - 8.6e-06 26.3 0.0 2.2e-05 25.0 0.0 1.7 2 0 0 2 2 1 1 AAA domain RNA_helicase PF00910.22 ETO33856.1 - 0.00033 21.0 0.0 0.00078 19.8 0.0 1.7 1 0 0 1 1 1 1 RNA helicase NACHT PF05729.12 ETO33856.1 - 0.00077 19.4 0.1 0.0044 16.9 0.0 2.1 1 1 0 2 2 2 1 NACHT domain AAA_33 PF13671.6 ETO33856.1 - 0.00089 19.4 0.0 0.0017 18.6 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_28 PF13521.6 ETO33856.1 - 0.0009 19.5 0.0 0.0016 18.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETO33856.1 - 0.0011 18.8 0.0 0.0024 17.7 0.0 1.6 1 0 0 1 1 1 1 AAA domain IstB_IS21 PF01695.17 ETO33856.1 - 0.0011 18.7 0.0 0.0017 18.1 0.0 1.4 1 0 0 1 1 1 1 IstB-like ATP binding protein TsaE PF02367.17 ETO33856.1 - 0.0014 18.7 0.0 0.0029 17.6 0.0 1.6 1 0 0 1 1 1 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_3 PF07726.11 ETO33856.1 - 0.002 18.0 0.0 0.052 13.4 0.0 2.2 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) RuvB_N PF05496.12 ETO33856.1 - 0.0021 17.9 0.0 0.004 16.9 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_30 PF13604.6 ETO33856.1 - 0.0028 17.4 0.0 0.0043 16.8 0.0 1.3 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO33856.1 - 0.0038 17.2 0.0 0.0086 16.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) DUF815 PF05673.13 ETO33856.1 - 0.0047 16.1 0.0 0.0092 15.2 0.0 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) TIP49 PF06068.13 ETO33856.1 - 0.0053 16.0 0.0 0.0083 15.4 0.0 1.3 1 0 0 1 1 1 1 TIP49 P-loop domain AAA_7 PF12775.7 ETO33856.1 - 0.0054 16.3 0.1 0.019 14.5 0.0 1.8 2 0 0 2 2 2 1 P-loop containing dynein motor region Cytidylate_kin PF02224.18 ETO33856.1 - 0.0062 16.3 0.0 0.019 14.7 0.0 1.8 2 0 0 2 2 2 1 Cytidylate kinase AAA_13 PF13166.6 ETO33856.1 - 0.012 14.3 0.0 0.017 13.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain MMR_HSR1 PF01926.23 ETO33856.1 - 0.013 15.6 0.1 0.29 11.2 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_24 PF13479.6 ETO33856.1 - 0.015 15.1 0.0 0.025 14.3 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF2075 PF09848.9 ETO33856.1 - 0.015 14.5 0.0 0.023 13.9 0.0 1.2 1 0 0 1 1 1 0 Uncharacterized conserved protein (DUF2075) Rad17 PF03215.15 ETO33856.1 - 0.021 14.8 0.0 0.039 13.9 0.0 1.5 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_25 PF13481.6 ETO33856.1 - 0.023 14.3 0.0 0.038 13.6 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_17 PF13207.6 ETO33856.1 - 0.027 14.9 0.0 0.099 13.1 0.0 2.1 2 0 0 2 2 2 0 AAA domain PhoH PF02562.16 ETO33856.1 - 0.029 13.8 0.0 0.061 12.8 0.0 1.5 1 0 0 1 1 1 0 PhoH-like protein ABC_tran PF00005.27 ETO33856.1 - 0.033 14.7 0.0 0.065 13.7 0.0 1.7 1 0 0 1 1 1 0 ABC transporter Mg_chelatase PF01078.21 ETO33856.1 - 0.036 13.4 0.0 0.059 12.7 0.0 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_19 PF13245.6 ETO33856.1 - 0.039 14.3 0.0 0.089 13.1 0.0 1.6 1 0 0 1 1 1 0 AAA domain AAA_14 PF13173.6 ETO33856.1 - 0.039 14.0 0.0 0.087 12.9 0.0 1.6 1 0 0 1 1 1 0 AAA domain DnaB_C PF03796.15 ETO33856.1 - 0.039 13.3 0.0 0.083 12.2 0.0 1.5 2 0 0 2 2 1 0 DnaB-like helicase C terminal domain PduV-EutP PF10662.9 ETO33856.1 - 0.048 13.4 0.0 0.11 12.2 0.0 1.6 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation NB-ARC PF00931.22 ETO33856.1 - 0.048 12.8 0.0 0.097 11.8 0.0 1.6 1 0 0 1 1 1 0 NB-ARC domain Sigma54_activat PF00158.26 ETO33856.1 - 0.092 12.5 0.0 0.15 11.8 0.0 1.3 1 0 0 1 1 1 0 Sigma-54 interaction domain CPT PF07931.12 ETO33856.1 - 0.11 12.3 0.0 0.18 11.6 0.0 1.3 1 0 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein RsgA_GTPase PF03193.16 ETO33856.1 - 0.12 12.3 0.0 0.24 11.3 0.0 1.5 1 0 0 1 1 1 0 RsgA GTPase ADK PF00406.22 ETO33856.1 - 0.17 12.0 0.1 8.6 6.5 0.0 2.3 2 0 0 2 2 2 0 Adenylate kinase FKBP_N PF01346.18 ETO33857.1 - 2.7e-07 31.4 0.1 4.5e-07 30.7 0.1 1.3 1 0 0 1 1 1 1 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase Drc1-Sld2 PF11719.8 ETO33858.1 - 0.00086 19.0 4.3 0.00086 19.0 4.3 1.6 2 0 0 2 2 2 1 DNA replication and checkpoint protein CDC45 PF02724.14 ETO33858.1 - 0.049 11.9 5.1 0.066 11.5 5.1 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop53 PF07767.11 ETO33858.1 - 0.29 10.5 13.3 0.39 10.0 13.3 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) HAND PF09110.11 ETO33858.1 - 0.47 11.2 12.4 1.1 10.1 12.4 1.5 1 0 0 1 1 1 0 HAND RR_TM4-6 PF06459.12 ETO33858.1 - 1.4 8.7 10.6 2.1 8.1 10.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4637 PF15470.6 ETO33858.1 - 4.1 7.1 11.3 7.9 6.2 11.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Actin PF00022.19 ETO33859.1 - 1.5e-38 132.5 0.0 1.8e-38 132.2 0.0 1.1 1 0 0 1 1 1 1 Actin Actin PF00022.19 ETO33860.1 - 1.8e-27 96.0 0.0 4.6e-27 94.7 0.0 1.6 1 1 0 1 1 1 1 Actin EcsB PF05975.12 ETO33861.1 - 0.0008 18.4 2.1 0.0008 18.4 2.1 2.2 3 0 0 3 3 3 1 Bacterial ABC transporter protein EcsB Sterile PF03015.19 ETO33862.1 - 0.06 13.6 0.1 0.28 11.4 0.0 2.0 2 0 0 2 2 2 0 Male sterility protein PI3K_C2 PF00792.24 ETO33863.1 - 1.9e-11 44.1 0.0 3.3e-11 43.3 0.0 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase C2 PI3K_rbd PF00794.18 ETO33863.1 - 2e-11 44.0 0.1 4.6e-11 42.8 0.1 1.6 1 0 0 1 1 1 1 PI3-kinase family, ras-binding domain PI3Ka PF00613.20 ETO33864.1 - 7.1e-47 159.2 3.7 1.2e-46 158.5 3.7 1.4 1 0 0 1 1 1 1 Phosphoinositide 3-kinase family, accessory domain (PIK domain) Glyco_hydro_4C PF11975.8 ETO33864.1 - 0.17 12.0 0.1 0.29 11.2 0.1 1.3 1 1 0 1 1 1 0 Family 4 glycosyl hydrolase C-terminal domain PI3_PI4_kinase PF00454.27 ETO33865.1 - 3.2e-33 115.6 0.2 5.2e-27 95.3 0.1 2.0 1 1 1 2 2 2 2 Phosphatidylinositol 3- and 4-kinase SUKH-3 PF14433.6 ETO33865.1 - 0.037 14.5 0.0 0.049 14.1 0.0 1.2 1 0 0 1 1 1 0 SUKH-3 immunity protein DUF4135 PF13575.6 ETO33865.1 - 0.066 12.5 0.0 0.077 12.3 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4135) DUF5644 PF18712.1 ETO33866.1 - 0.012 15.6 1.0 0.026 14.5 0.1 2.0 2 0 0 2 2 2 0 Family of unknown function (DUF5644) LLC1 PF14945.6 ETO33867.1 - 0.027 15.0 1.1 0.08 13.5 0.1 2.2 1 1 1 2 2 2 0 Normal lung function maintenance, Low in Lung Cancer 1 protein OAD_gamma PF04277.13 ETO33868.1 - 0.0078 16.8 0.0 0.011 16.3 0.0 1.2 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain WBP-1 PF11669.8 ETO33868.1 - 0.044 14.4 1.4 0.076 13.7 0.8 1.6 2 0 0 2 2 2 0 WW domain-binding protein 1 ETRAMP PF09716.10 ETO33868.1 - 0.081 13.0 1.8 0.15 12.2 1.8 1.4 1 0 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) TMEM52 PF14979.6 ETO33868.1 - 0.091 12.7 0.9 0.14 12.1 0.9 1.2 1 0 0 1 1 1 0 Transmembrane 52 5_3_exonuc PF01367.20 ETO33868.1 - 0.099 13.3 0.0 0.16 12.6 0.0 1.4 1 0 0 1 1 1 0 5'-3' exonuclease, C-terminal SAM fold Mucin PF01456.17 ETO33868.1 - 0.13 12.2 0.1 0.18 11.8 0.1 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein XPG_N PF00752.17 ETO33869.1 - 2.1e-20 73.1 0.0 6.1e-20 71.6 0.0 1.8 2 0 0 2 2 2 1 XPG N-terminal domain XPG_I PF00867.18 ETO33869.1 - 2.7e-18 66.1 0.1 1.9e-17 63.4 0.0 2.3 2 1 0 2 2 2 1 XPG I-region XPG_I_2 PF12813.7 ETO33869.1 - 2e-07 30.7 0.0 4.4e-07 29.6 0.0 1.5 1 1 0 1 1 1 1 XPG domain containing TPR_2 PF07719.17 ETO33869.1 - 0.0023 17.9 0.0 0.0056 16.7 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33869.1 - 0.0031 17.6 0.1 0.0031 17.6 0.1 2.7 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33869.1 - 0.012 16.2 0.1 0.04 14.5 0.1 1.8 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33869.1 - 0.023 14.5 0.0 0.076 12.9 0.0 2.0 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33869.1 - 0.065 13.3 0.0 0.14 12.2 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO33869.1 - 0.066 14.1 0.0 0.16 12.8 0.0 1.7 1 0 0 1 1 1 0 Tetratricopeptide repeat Pkinase PF00069.25 ETO33875.1 - 3.4e-08 33.2 0.3 5.8e-08 32.4 0.3 1.3 1 0 0 1 1 1 1 Protein kinase domain PH PF00169.29 ETO33875.1 - 2.3e-07 31.3 0.1 3.8e-07 30.6 0.1 1.4 1 0 0 1 1 1 1 PH domain Pkinase_Tyr PF07714.17 ETO33875.1 - 0.00014 21.3 0.1 0.0002 20.7 0.1 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PH_11 PF15413.6 ETO33875.1 - 0.17 12.4 1.2 0.37 11.2 0.3 2.3 2 1 0 2 2 2 0 Pleckstrin homology domain NACHT PF05729.12 ETO33876.1 - 4.8e-10 39.6 0.0 2.5e-09 37.3 0.0 2.2 3 0 0 3 3 3 1 NACHT domain cPLA2_C2 PF18695.1 ETO33876.1 - 0.00029 20.8 1.0 0.0015 18.5 0.0 2.4 2 0 0 2 2 2 1 Cytosolic phospholipases A2 C2-domain AAA_18 PF13238.6 ETO33876.1 - 0.001 19.6 0.0 0.0053 17.3 0.0 2.3 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO33876.1 - 0.0016 18.7 0.0 0.0055 17.0 0.0 2.0 1 0 0 1 1 1 1 AAA domain DAP3 PF10236.9 ETO33876.1 - 0.0041 16.4 1.4 0.69 9.0 0.2 3.3 3 0 0 3 3 3 1 Mitochondrial ribosomal death-associated protein 3 TniB PF05621.11 ETO33876.1 - 0.017 14.5 0.1 0.037 13.4 0.1 1.5 1 0 0 1 1 1 0 Bacterial TniB protein ATP_bind_2 PF03668.15 ETO33876.1 - 0.023 14.0 0.0 0.045 13.0 0.0 1.5 1 0 0 1 1 1 0 P-loop ATPase protein family RNA_helicase PF00910.22 ETO33876.1 - 0.023 15.1 1.3 0.17 12.3 0.0 3.1 3 1 0 3 3 3 0 RNA helicase ABC_tran PF00005.27 ETO33876.1 - 0.036 14.6 0.1 4.3 7.8 0.0 2.9 2 0 0 2 2 2 0 ABC transporter MCR_gamma PF02240.16 ETO33876.1 - 0.052 12.8 0.2 0.099 11.9 0.2 1.5 1 0 0 1 1 1 0 Methyl-coenzyme M reductase gamma subunit UCH PF00443.29 ETO33877.1 - 8.3e-11 41.9 0.5 2.2e-10 40.5 0.5 1.8 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase Dicty_REP PF05086.12 ETO33877.1 - 0.056 11.4 8.6 0.092 10.7 8.6 1.3 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Tir_receptor_C PF07489.11 ETO33877.1 - 0.39 10.6 3.4 0.76 9.7 3.4 1.4 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus NAM-associated PF14303.6 ETO33877.1 - 1.1 9.9 11.0 0.18 12.5 6.7 1.8 2 0 0 2 2 2 0 No apical meristem-associated C-terminal domain DUF4647 PF15504.6 ETO33879.1 - 0.0071 15.5 8.3 0.011 14.9 8.3 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4647) NPR3 PF03666.13 ETO33879.1 - 0.036 12.9 9.6 0.052 12.3 9.6 1.3 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO33879.1 - 0.05 12.4 11.1 0.063 12.0 11.1 1.1 1 0 0 1 1 1 0 Presenilin FAM60A PF15396.6 ETO33879.1 - 0.9 9.5 10.2 1.3 9.0 10.2 1.3 1 0 0 1 1 1 0 Protein Family FAM60A SLC12 PF03522.15 ETO33879.1 - 1.2 8.0 13.1 1.6 7.7 13.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 RVT_1 PF00078.27 ETO33881.1 - 9e-07 28.6 0.6 0.00014 21.5 0.0 2.2 2 0 0 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) TssC PF17541.2 ETO33881.1 - 0.1 11.4 0.0 0.15 10.8 0.0 1.2 1 0 0 1 1 1 0 Type VI secretion system, TssC, VipB NACHT PF05729.12 ETO33882.1 - 1.8e-18 67.0 0.0 7.9e-18 64.9 0.0 2.3 1 0 0 1 1 1 1 NACHT domain HEAT PF02985.22 ETO33882.1 - 8.3e-13 47.4 0.1 0.59 10.5 0.0 8.5 9 0 0 9 9 9 2 HEAT repeat RTP1_C1 PF10363.9 ETO33882.1 - 9.9e-07 28.9 19.5 0.48 10.6 0.4 7.4 6 0 0 6 6 6 2 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_2 PF13646.6 ETO33882.1 - 7.3e-06 26.3 0.0 0.0053 17.1 0.0 5.2 5 2 1 7 7 7 1 HEAT repeats Ank_3 PF13606.6 ETO33882.1 - 1.9e-05 24.7 0.1 0.00029 21.0 0.0 3.2 2 0 0 2 2 2 1 Ankyrin repeat Ank_5 PF13857.6 ETO33882.1 - 3.4e-05 24.0 0.1 0.00012 22.3 0.1 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO33882.1 - 5.4e-05 23.6 0.6 0.0006 20.3 0.3 3.1 2 0 0 2 2 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO33882.1 - 8.9e-05 23.0 0.7 0.0084 16.7 0.0 3.7 3 0 0 3 3 2 1 Ankyrin repeats (3 copies) HEAT_EZ PF13513.6 ETO33882.1 - 0.00045 20.7 0.0 5.6 7.6 0.0 5.2 4 1 1 5 5 5 1 HEAT-like repeat Ank PF00023.30 ETO33882.1 - 0.02 15.4 0.1 0.25 11.9 0.0 2.9 3 0 0 3 3 2 0 Ankyrin repeat AAA_16 PF13191.6 ETO33882.1 - 0.036 14.5 0.0 0.31 11.4 0.0 2.7 2 1 0 2 2 2 0 AAA ATPase domain HTH_40 PF14493.6 ETO33882.1 - 0.038 14.5 1.4 13 6.3 0.0 5.1 4 0 0 4 4 3 0 Helix-turn-helix domain Cytochrom_C PF00034.21 ETO33882.1 - 0.052 14.7 0.1 65 4.8 0.0 4.5 4 0 0 4 4 3 0 Cytochrome c NLRC4_HD2 PF17776.1 ETO33882.1 - 0.053 14.1 0.0 0.053 14.1 0.0 7.1 6 4 4 10 10 8 0 NLRC4 helical domain HD2 AAA_22 PF13401.6 ETO33882.1 - 0.41 10.9 6.4 0.47 10.7 0.0 4.5 5 0 0 5 5 4 0 AAA domain BP28CT PF08146.12 ETO33882.1 - 7.3 6.4 27.9 3.6 7.4 0.2 7.7 5 3 1 6 6 6 0 BP28CT (NUC211) domain Cys_box PF17869.1 ETO33883.1 - 0.11 12.6 4.1 0.18 12.0 4.1 1.3 1 0 0 1 1 1 0 Anosmin cysteine rich domain Leuk-A4-hydro_C PF09127.11 ETO33883.1 - 0.14 12.2 6.9 0.22 11.6 0.5 2.7 1 1 2 3 3 3 0 Leukotriene A4 hydrolase, C-terminal DUF2113 PF09886.9 ETO33884.1 - 0.062 12.6 0.1 0.08 12.3 0.1 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in archaea (DUF2113) DUF1214 PF06742.11 ETO33885.1 - 0.037 14.4 1.4 0.049 14.1 1.4 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1214) TPR_12 PF13424.6 ETO33887.1 - 9.1e-57 189.3 7.8 2.8e-17 62.7 1.2 6.2 3 1 2 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO33887.1 - 2.9e-38 128.7 2.8 8.3e-06 25.5 0.1 8.7 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO33887.1 - 8.9e-32 106.8 16.5 0.00053 19.8 0.1 9.4 10 0 0 10 10 9 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO33887.1 - 3.4e-31 105.8 33.0 4.4e-06 26.3 1.0 9.9 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO33887.1 - 8.2e-28 94.3 35.7 1e-05 25.4 1.0 9.6 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO33887.1 - 3.9e-27 92.1 26.1 3.4e-05 23.6 0.1 9.5 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO33887.1 - 3.6e-14 52.9 0.0 5.8e-07 29.2 0.0 2.3 1 1 1 2 2 2 2 MalT-like TPR region TPR_14 PF13428.6 ETO33887.1 - 8.8e-12 44.8 0.1 0.96 10.4 0.0 7.3 9 0 0 9 9 7 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO33887.1 - 2.3e-11 43.3 3.8 4.6 7.8 0.0 8.0 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO33887.1 - 1.7e-09 37.7 8.7 0.23 12.2 0.1 6.6 6 0 0 6 6 5 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO33887.1 - 7.5e-08 32.8 4.6 1.5 9.4 0.1 6.3 6 1 1 7 7 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO33887.1 - 9.1e-08 31.7 22.2 0.066 12.9 0.3 7.6 8 0 0 8 8 7 2 TPR repeat TPR_21 PF09976.9 ETO33887.1 - 2.3e-05 24.2 3.5 0.033 13.9 0.0 3.3 3 1 0 3 3 3 2 Tetratricopeptide repeat-like domain TPR_16 PF13432.6 ETO33887.1 - 3e-05 24.6 0.0 9.6 6.9 0.0 5.6 7 0 0 7 7 6 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO33887.1 - 9.9e-05 22.2 10.9 1.7 8.4 0.1 6.4 4 1 3 7 7 7 1 Domain of unknown function (DUF5113) MIT PF04212.18 ETO33887.1 - 0.00022 21.2 20.1 2.1 8.4 0.1 6.3 6 1 0 6 6 5 3 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO33887.1 - 0.00046 20.1 10.1 0.23 11.5 0.2 4.2 3 0 0 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO33887.1 - 0.015 14.8 12.6 0.13 11.8 0.1 6.4 7 0 0 7 7 7 0 SHNi-TPR RPN7 PF10602.9 ETO33887.1 - 0.045 13.4 15.9 1.7 8.3 1.3 4.2 3 2 1 4 4 4 0 26S proteasome subunit RPN7 Fis1_TPR_C PF14853.6 ETO33887.1 - 0.093 12.8 10.3 1.4 9.1 0.5 4.9 4 1 1 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat DUF2225 PF09986.9 ETO33887.1 - 0.48 10.1 14.9 4.7 6.9 2.1 4.3 1 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) PPR PF01535.20 ETO33887.1 - 0.54 10.6 10.7 13 6.3 0.0 6.3 8 0 0 8 8 7 0 PPR repeat HTH_Bact PF18768.1 ETO33887.1 - 4.7 6.9 9.8 89 2.8 0.1 5.8 6 2 1 7 7 7 0 Helix-turn-helix bacterial domain Conotoxin PF02950.17 ETO33888.1 - 0.043 14.8 0.7 0.21 12.6 0.0 2.4 3 0 0 3 3 3 0 Conotoxin Nucleoside_tran PF01733.18 ETO33888.1 - 0.24 10.7 3.8 0.21 11.0 2.0 1.4 1 1 0 1 1 1 0 Nucleoside transporter WD40 PF00400.32 ETO33890.1 - 3.8e-39 132.0 18.2 2.9e-06 27.9 0.1 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33890.1 - 8.2e-10 38.9 0.5 0.078 13.3 0.0 4.8 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33890.1 - 1.4e-06 27.3 7.1 0.0047 15.6 0.9 3.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33890.1 - 6.5e-06 25.7 5.6 0.00068 19.0 0.5 3.8 3 1 1 4 4 4 2 WD40-like domain DUF1541 PF07563.11 ETO33890.1 - 0.009 15.9 1.0 5.7 6.9 0.1 3.1 3 0 0 3 3 3 2 Protein of unknown function (DUF1541) WD40 PF00400.32 ETO33891.1 - 3.2e-53 176.5 19.2 7e-10 39.3 0.1 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33891.1 - 4.8e-19 68.4 0.4 0.0015 18.8 0.0 5.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO33891.1 - 2e-11 44.1 0.6 2.2e-05 24.4 0.0 3.0 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO33891.1 - 6.1e-10 38.6 0.4 0.15 11.0 0.0 5.6 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33891.1 - 9e-09 35.1 0.4 0.0006 19.2 0.1 3.3 2 2 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO33891.1 - 1.7e-08 33.6 6.3 0.075 11.7 0.0 5.3 3 2 3 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO33891.1 - 1.6e-05 23.6 0.2 0.00023 19.8 0.1 1.9 1 1 0 2 2 2 1 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO33891.1 - 0.0001 21.2 4.5 0.46 9.2 0.0 4.0 1 1 2 4 4 4 2 Nup133 N terminal like PD40 PF07676.12 ETO33891.1 - 0.00014 21.7 1.7 4.3 7.4 0.0 5.1 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO33891.1 - 0.0003 20.0 0.2 0.14 11.2 0.1 2.6 1 1 2 3 3 3 2 Coatomer WD associated region DUF4221 PF13970.6 ETO33891.1 - 0.0055 16.3 0.3 0.25 10.8 0.0 3.0 1 1 3 4 4 4 1 Domain of unknown function (DUF4221) DPPIV_N PF00930.21 ETO33891.1 - 0.036 12.8 0.0 7.7 5.2 0.0 3.1 1 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region HPS3_N PF14761.6 ETO33891.1 - 0.065 12.8 0.0 0.16 11.5 0.0 1.8 2 0 0 2 2 2 0 Hermansky-Pudlak syndrome 3 B3_4 PF03483.17 ETO33891.1 - 0.085 12.5 0.0 0.17 11.5 0.0 1.5 1 0 0 1 1 1 0 B3/4 domain DUF1513 PF07433.11 ETO33891.1 - 0.18 10.8 0.1 8.4 5.4 0.0 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1513) DUF4261 PF14080.6 ETO33891.1 - 0.63 10.2 2.0 74 3.6 1.3 3.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4261) FHA PF00498.26 ETO33892.1 - 0.0032 17.8 0.0 0.0071 16.7 0.0 1.6 2 0 0 2 2 2 1 FHA domain Dfp1_Him1_M PF08630.10 ETO33892.1 - 0.024 14.8 1.1 0.076 13.2 0.0 1.9 1 1 1 2 2 2 0 Dfp1/Him1, central region tRNA_anti-like PF12869.7 ETO33892.1 - 0.033 13.8 0.1 0.052 13.2 0.1 1.3 1 0 0 1 1 1 0 tRNA_anti-like WD40_like PF17005.5 ETO33892.1 - 0.044 13.1 0.0 0.053 12.8 0.0 1.1 1 0 0 1 1 1 0 WD40-like domain eIF-4B PF06273.11 ETO33892.1 - 0.046 12.8 1.5 0.06 12.4 1.5 1.1 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B Dicty_REP PF05086.12 ETO33892.1 - 0.1 10.6 2.4 0.13 10.2 2.4 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TraF PF13728.6 ETO33892.1 - 0.14 12.0 3.0 0.23 11.3 3.0 1.3 1 0 0 1 1 1 0 F plasmid transfer operon protein Jak1_Phl PF17887.1 ETO33893.1 - 0.23 11.4 8.3 0.75 9.8 3.9 2.3 2 0 0 2 2 2 0 Jak1 pleckstrin homology-like domain Peptidase_S49_N PF08496.10 ETO33893.1 - 1.4 9.0 6.4 3.1 7.8 6.4 1.7 1 0 0 1 1 1 0 Peptidase family S49 N-terminal VWA_3 PF13768.6 ETO33894.1 - 0.00014 21.9 0.0 0.002 18.1 0.0 2.6 3 0 0 3 3 3 1 von Willebrand factor type A domain Helicase_C PF00271.31 ETO33894.1 - 0.00041 20.7 1.1 0.005 17.2 0.1 3.0 3 1 0 3 3 3 1 Helicase conserved C-terminal domain VWA PF00092.28 ETO33894.1 - 0.0029 17.9 0.1 0.014 15.6 0.0 2.0 2 1 0 2 2 2 1 von Willebrand factor type A domain DUF1330 PF07045.11 ETO33894.1 - 0.12 12.7 0.1 0.46 10.9 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1330) VWA_2 PF13519.6 ETO33894.1 - 0.13 13.0 0.0 0.45 11.2 0.0 2.0 2 1 0 2 2 2 0 von Willebrand factor type A domain Hph PF13694.6 ETO33895.1 - 0.0097 16.2 0.5 0.015 15.6 0.5 1.3 1 0 0 1 1 1 1 Sec63/Sec62 complex-interacting family Beach PF02138.18 ETO33896.1 - 1.9e-105 352.2 0.5 1.9e-105 352.2 0.5 1.9 2 0 0 2 2 2 1 Beige/BEACH domain FYVE PF01363.21 ETO33896.1 - 3.4e-18 65.6 8.9 3.4e-18 65.6 8.9 1.8 2 0 0 2 2 2 1 FYVE zinc finger WD40 PF00400.32 ETO33896.1 - 7.3e-11 42.4 16.9 1.5e-07 31.9 0.1 5.5 5 1 0 5 5 5 2 WD domain, G-beta repeat PH_BEACH PF14844.6 ETO33896.1 - 2.8e-09 37.0 0.2 2.8e-09 37.0 0.2 2.4 2 0 0 2 2 2 1 PH domain associated with Beige/BEACH ANAPC4_WD40 PF12894.7 ETO33896.1 - 6.5e-05 23.2 1.2 0.006 16.9 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IBR PF01485.21 ETO33896.1 - 0.00087 19.5 7.6 0.0023 18.1 7.6 1.7 1 0 0 1 1 1 1 IBR domain, a half RING-finger domain FYVE_2 PF02318.16 ETO33896.1 - 0.74 10.0 5.6 2.7 8.3 5.6 1.9 1 0 0 1 1 1 0 FYVE-type zinc finger Ribosomal_S27e PF01667.17 ETO33896.1 - 4.1 7.2 8.5 1.3e+02 2.4 8.2 3.2 3 0 0 3 3 3 0 Ribosomal protein S27 zf-RING_5 PF14634.6 ETO33896.1 - 7.7 6.6 10.2 18 5.4 10.2 1.7 1 0 0 1 1 1 0 zinc-RING finger domain Baculo_gp64 PF03273.13 ETO33897.1 - 0.009 14.9 0.4 0.013 14.3 0.4 1.2 1 0 0 1 1 1 1 Baculovirus gp64 envelope glycoprotein family MotY_N PF18393.1 ETO33897.1 - 3.9 7.6 7.5 0.68 10.1 0.3 2.9 3 0 0 3 3 3 0 MotY N-terminal domain DUF2222 PF09984.9 ETO33898.1 - 0.024 14.5 1.2 0.038 13.9 1.2 1.3 1 0 0 1 1 1 0 Uncharacterised signal transduction histidine kinase domain (DUF2222) DUF2721 PF11026.8 ETO33898.1 - 0.77 9.7 9.8 0.21 11.5 4.4 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2721) Far-17a_AIG1 PF04750.14 ETO33899.1 - 6.2e-08 32.2 7.4 9.2e-08 31.6 7.4 1.2 1 0 0 1 1 1 1 FAR-17a/AIG1-like protein Bap31 PF05529.12 ETO33899.1 - 0.021 14.7 0.2 9.2 6.1 0.0 2.5 2 0 0 2 2 2 0 Bap31/Bap29 transmembrane region TMEM192 PF14802.6 ETO33899.1 - 0.17 11.0 3.5 0.28 10.2 3.5 1.3 1 0 0 1 1 1 0 TMEM192 family SR-25 PF10500.9 ETO33900.1 - 0.0053 16.4 6.2 0.0053 16.4 6.2 3.2 2 1 1 3 3 3 1 Nuclear RNA-splicing-associated protein Adap_comp_sub PF00928.21 ETO33901.1 - 3.8e-46 157.6 0.1 4.8e-46 157.3 0.1 1.1 1 0 0 1 1 1 1 Adaptor complexes medium subunit family S1FA PF04689.13 ETO33901.1 - 0.019 15.1 0.1 0.042 14.0 0.1 1.5 1 0 0 1 1 1 0 DNA binding protein S1FA FANCM-MHF_bd PF16783.5 ETO33902.1 - 6 7.0 10.3 3.1 7.9 0.2 2.9 2 1 0 2 2 2 0 FANCM to MHF binding domain Crr6 PF08847.11 ETO33904.1 - 0.016 14.9 0.2 0.05 13.3 0.1 1.9 1 1 0 1 1 1 0 Chlororespiratory reduction 6 SpvB PF03534.13 ETO33904.1 - 0.052 12.7 2.0 0.077 12.2 2.0 1.2 1 0 0 1 1 1 0 Salmonella virulence plasmid 65kDa B protein DUF1093 PF06486.11 ETO33904.1 - 0.54 11.0 5.5 0.1 13.3 1.9 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1093) Macoilin PF09726.9 ETO33905.1 - 1.3 7.5 33.5 1.1 7.7 32.6 1.4 1 1 0 1 1 1 0 Macoilin family WD40 PF00400.32 ETO33906.1 - 3.5e-37 125.8 10.6 2.7e-07 31.1 0.0 5.1 4 1 1 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33906.1 - 8.9e-10 38.7 1.4 0.032 14.5 0.0 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33906.1 - 2.5e-08 33.3 0.3 0.05 12.6 0.0 4.5 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO33906.1 - 1.4e-05 24.0 3.0 0.42 9.2 0.1 4.0 1 1 1 4 4 4 3 Nucleoporin Nup120/160 SGL PF08450.12 ETO33906.1 - 0.0024 17.5 0.0 0.22 11.1 0.0 3.0 1 1 2 3 3 3 1 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 ETO33906.1 - 0.03 14.3 8.0 1.9 8.5 0.0 4.2 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat AlphaC_N PF08829.10 ETO33906.1 - 0.083 12.9 0.0 0.18 11.8 0.0 1.7 1 1 1 2 2 2 0 Alpha C protein N terminal Proteasome_A_N PF10584.9 ETO33906.1 - 1.8 8.3 4.1 38 4.1 0.1 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO33907.1 - 1.3e-39 133.5 15.7 1.6e-10 41.4 0.1 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33907.1 - 7.6e-10 39.0 3.4 0.041 14.2 0.1 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33907.1 - 2.6e-07 29.7 1.6 0.065 11.9 0.0 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33907.1 - 2.8e-05 23.6 0.4 0.012 14.9 0.1 2.7 1 1 3 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO33907.1 - 4.6e-05 22.5 0.2 4.6 6.1 0.0 3.9 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein POLO_box PF00659.18 ETO33907.1 - 0.0056 16.8 0.1 2.1 8.6 0.0 3.3 3 1 0 3 3 3 1 POLO box duplicated region Nucleoporin_N PF08801.11 ETO33907.1 - 0.014 14.1 6.6 0.46 9.2 0.8 3.1 1 1 1 3 3 3 0 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO33907.1 - 0.035 12.6 0.3 0.75 8.3 0.1 2.2 1 1 0 2 2 2 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO33907.1 - 0.04 12.8 0.0 3.3 6.5 0.0 2.7 2 1 1 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) Str_synth PF03088.16 ETO33907.1 - 0.05 13.7 0.0 0.13 12.4 0.0 1.8 1 1 0 1 1 1 0 Strictosidine synthase PBP1_TM PF14812.6 ETO33908.1 - 0.07 13.5 5.6 0.11 12.9 5.1 1.6 1 1 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Cwf_Cwc_15 PF04889.12 ETO33908.1 - 0.4 10.4 8.4 0.55 9.9 8.4 1.2 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein TFIIA PF03153.13 ETO33908.1 - 1.6 8.6 11.1 2.7 7.9 11.1 1.4 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit DNA_pol_phi PF04931.13 ETO33908.1 - 5.6 4.9 6.7 7.3 4.6 6.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi TAF4 PF05236.14 ETO33909.1 - 0.07 12.9 1.3 0.14 11.9 1.3 1.6 1 1 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family WD40 PF00400.32 ETO33910.1 - 3.1e-56 186.1 17.6 2.2e-09 37.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33910.1 - 3.4e-17 62.5 4.6 0.24 11.7 0.1 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO33910.1 - 8e-11 42.2 1.8 0.00012 22.0 0.1 3.3 1 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO33910.1 - 1.6e-10 40.3 5.0 0.09 11.4 0.0 5.1 1 1 3 5 5 5 4 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO33910.1 - 4.1e-10 39.1 4.1 0.81 8.6 0.0 6.0 1 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33910.1 - 4.3e-08 32.8 8.6 0.0062 15.9 0.6 3.5 1 1 3 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO33910.1 - 7.9e-08 31.2 3.7 0.0058 15.2 0.3 3.8 1 1 3 4 4 4 2 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO33910.1 - 0.00069 18.8 6.2 0.098 11.7 0.4 3.1 1 1 2 3 3 3 3 Coatomer WD associated region Str_synth PF03088.16 ETO33910.1 - 0.0014 18.7 1.6 8.6 6.6 0.0 4.4 3 3 2 5 5 5 1 Strictosidine synthase Mid2 PF04478.12 ETO33910.1 - 0.0019 18.0 0.6 11 5.9 0.0 3.7 2 1 1 4 4 4 0 Mid2 like cell wall stress sensor DUF5570 PF17731.1 ETO33910.1 - 0.0027 17.8 0.4 7.8 6.6 0.1 4.2 1 1 2 5 5 5 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO33910.1 - 0.0033 16.8 0.9 0.5 9.7 0.1 2.9 1 1 2 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO33910.1 - 0.0037 17.2 7.5 0.48 10.4 0.0 5.0 6 1 0 6 6 6 1 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO33910.1 - 0.0038 16.3 0.2 0.045 12.8 0.1 2.4 1 1 1 2 2 2 2 VID27 C-terminal WD40-like domain Me-amine-dh_H PF06433.11 ETO33910.1 - 0.027 13.3 0.1 0.87 8.4 0.0 2.8 2 1 1 4 4 4 0 Methylamine dehydrogenase heavy chain (MADH) RabGAP-TBC PF00566.18 ETO33910.1 - 0.029 14.0 0.2 69 3.0 0.0 4.1 5 0 0 5 5 5 0 Rab-GTPase-TBC domain DUF2194 PF09960.9 ETO33910.1 - 0.049 12.0 0.9 0.27 9.5 0.1 2.0 2 0 0 2 2 2 0 Uncharacterised protein conserved in bacteria (DUF2194) PQQ_2 PF13360.6 ETO33910.1 - 0.062 12.9 0.0 0.26 10.9 0.0 2.0 1 1 0 1 1 1 0 PQQ-like domain DPPIV_N PF00930.21 ETO33910.1 - 0.1 11.3 1.0 6.6 5.4 0.0 3.0 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Plk4_PB1 PF18190.1 ETO33910.1 - 0.21 11.8 2.3 31 4.8 0.1 3.6 3 1 1 4 4 4 0 Polo-like Kinase 4 Polo Box 1 PilJ PF13675.6 ETO33911.1 - 0.039 14.0 0.0 0.056 13.5 0.0 1.3 1 0 0 1 1 1 0 Type IV pili methyl-accepting chemotaxis transducer N-term WD40 PF00400.32 ETO33912.1 - 3.6e-55 182.7 13.6 1.2e-08 35.4 0.0 7.6 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33912.1 - 1.8e-19 69.8 1.0 0.04 14.2 0.0 7.2 2 2 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33912.1 - 2.8e-12 46.3 3.7 0.38 9.7 0.0 6.9 2 1 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO33912.1 - 3e-09 36.6 4.9 0.13 11.6 0.0 5.2 2 2 3 5 5 5 4 WD40-like domain Nup160 PF11715.8 ETO33912.1 - 1.2e-06 27.5 3.7 1.6 7.3 0.1 5.1 2 2 3 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO33912.1 - 0.0026 16.4 0.1 0.56 8.7 0.0 2.9 1 1 2 3 3 3 3 Cytochrome D1 heme domain PQQ PF01011.21 ETO33912.1 - 0.0059 16.5 0.0 19 5.4 0.0 4.5 4 0 0 4 4 4 0 PQQ enzyme repeat RAB3GAP2_N PF14655.6 ETO33912.1 - 0.0077 15.5 0.1 0.071 12.4 0.0 2.4 2 0 0 2 2 2 1 Rab3 GTPase-activating protein regulatory subunit N-terminus DUF1797 PF08796.10 ETO33912.1 - 0.063 13.4 0.0 7.3 6.8 0.0 3.1 3 0 0 3 3 3 0 Protein of unknown function (DUF1797) Kelch_2 PF07646.15 ETO33912.1 - 0.17 11.9 0.8 7.6 6.7 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Proteasome_A_N PF10584.9 ETO33912.1 - 0.21 11.3 3.2 9.2 6.0 0.0 4.1 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature PD40 PF07676.12 ETO33912.1 - 0.31 11.0 10.8 13 5.9 0.3 4.4 5 0 0 5 5 4 0 WD40-like Beta Propeller Repeat Spore_YpjB PF09577.10 ETO33913.1 - 0.021 14.6 0.5 0.026 14.3 0.5 1.1 1 0 0 1 1 1 0 Sporulation protein YpjB (SpoYpjB) LRS4 PF10422.9 ETO33913.1 - 0.1 12.2 7.5 0.16 11.5 7.5 1.2 1 0 0 1 1 1 0 Monopolin complex subunit LRS4 WD40 PF00400.32 ETO33916.1 - 3.9e-48 160.4 17.4 9.8e-11 42.0 0.4 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33916.1 - 5.5e-14 52.2 1.4 0.34 11.2 0.1 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33916.1 - 6.2e-13 48.4 1.6 0.00021 20.4 0.1 4.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO33916.1 - 2.5e-06 26.3 0.4 0.0073 14.9 0.0 2.9 3 0 0 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO33916.1 - 6.5e-06 25.1 3.5 0.3 9.7 0.5 4.2 1 1 3 5 5 5 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO33916.1 - 0.00038 19.3 2.9 0.23 10.2 0.1 3.6 1 1 3 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 ETO33916.1 - 0.0063 15.9 0.8 0.036 13.4 0.2 2.3 1 1 1 2 2 2 1 WD40-like domain PD40 PF07676.12 ETO33916.1 - 0.027 14.4 6.6 4.9 7.2 0.0 5.1 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat HSP70 PF00012.20 ETO33917.1 - 7.2e-07 27.8 0.1 0.0023 16.2 0.0 2.3 2 1 0 2 2 2 2 Hsp70 protein WD40 PF00400.32 ETO33918.1 - 7.2e-38 127.9 31.5 5.2e-07 30.3 0.1 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO33918.1 - 5.9e-10 38.4 7.9 0.00019 20.2 1.0 4.6 2 2 2 5 5 5 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33918.1 - 1.3e-08 35.0 1.0 1.1 9.7 0.0 5.3 3 2 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO33918.1 - 0.084 11.6 6.1 0.28 9.9 2.1 3.3 1 1 1 3 3 3 0 Nup133 N terminal like WD40 PF00400.32 ETO33919.1 - 7.1e-35 118.4 23.6 8.1e-06 26.5 0.6 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO33919.1 - 8.4e-09 34.6 3.2 0.054 12.1 0.1 4.0 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO33919.1 - 1.2e-07 32.0 2.5 0.039 14.3 0.0 5.5 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33919.1 - 8.9e-06 25.2 6.0 0.025 13.9 0.4 4.2 2 2 1 4 4 4 2 WD40-like domain GPR_Gpa2_C PF11970.8 ETO33919.1 - 0.19 11.8 2.4 0.39 10.8 2.4 1.5 1 0 0 1 1 1 0 G protein-coupled glucose receptor regulating Gpa2 C-term NFACT-C PF11923.8 ETO33920.1 - 0.0098 15.8 0.2 0.013 15.4 0.2 1.3 1 0 0 1 1 1 1 NFACT protein C-terminal domain DUF3456 PF11938.8 ETO33920.1 - 0.012 16.2 1.1 0.016 15.7 1.1 1.2 1 0 0 1 1 1 0 TLR4 regulator and MIR-interacting MSAP tRNA_SAD PF07973.14 ETO33922.1 - 1.2e-07 31.7 0.9 3.4e-07 30.3 0.9 1.8 1 1 0 1 1 1 1 Threonyl and Alanyl tRNA synthetase second additional domain RWD PF05773.22 ETO33922.1 - 0.084 13.2 0.0 0.18 12.1 0.0 1.6 1 0 0 1 1 1 0 RWD domain Peptidase_S74 PF13884.6 ETO33923.1 - 0.07 13.5 0.3 0.11 12.8 0.3 1.4 1 0 0 1 1 1 0 Chaperone of endosialidase DUF2457 PF10446.9 ETO33924.1 - 0.59 9.2 38.4 0.062 12.5 27.5 2.0 1 1 0 2 2 2 0 Protein of unknown function (DUF2457) RGS PF00615.19 ETO33925.1 - 1.3e-07 31.9 0.1 0.0046 17.2 0.1 2.7 2 0 0 2 2 2 2 Regulator of G protein signaling domain DUF3438 PF11920.8 ETO33925.1 - 0.058 12.6 0.6 0.13 11.5 0.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3438) BSP_II PF05432.11 ETO33925.1 - 0.061 13.0 16.3 0.12 12.1 16.3 1.4 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Nairovirus_M PF07948.11 ETO33925.1 - 0.12 10.6 1.3 0.18 10.0 1.3 1.2 1 0 0 1 1 1 0 Nairovirus M polyprotein-like CSG2 PF16965.5 ETO33925.1 - 0.14 11.0 0.7 0.32 9.9 0.7 1.5 1 0 0 1 1 1 0 Ceramide synthase regulator Serinc PF03348.15 ETO33925.1 - 0.25 10.3 0.4 0.51 9.2 0.2 1.6 2 0 0 2 2 2 0 Serine incorporator (Serinc) Zip PF02535.22 ETO33925.1 - 0.47 9.6 3.5 0.42 9.8 1.0 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter Ureide_permease PF07168.11 ETO33925.1 - 0.54 8.9 2.7 1.3 7.6 2.7 1.6 1 0 0 1 1 1 0 Ureide permease LRR19-TM PF15176.6 ETO33925.1 - 0.78 9.8 4.7 1.5 8.9 0.1 2.7 2 0 0 2 2 2 0 Leucine-rich repeat family 19 TM domain Presenilin PF01080.17 ETO33925.1 - 2 7.1 8.8 0.64 8.7 4.2 2.1 2 0 0 2 2 2 0 Presenilin SID-1_RNA_chan PF13965.6 ETO33925.1 - 4.4 5.6 5.0 0.58 8.5 0.5 1.8 3 0 0 3 3 3 0 dsRNA-gated channel SID-1 DUF4834 PF16118.5 ETO33925.1 - 7.7 7.6 9.1 2.8 9.0 3.4 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) SR-25 PF10500.9 ETO33926.1 - 0.00042 20.0 2.3 0.00057 19.6 2.3 1.3 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 ETO33926.1 - 0.015 13.6 7.7 0.017 13.5 7.7 1.0 1 0 0 1 1 1 0 CDC45-like protein BUD22 PF09073.10 ETO33926.1 - 0.018 14.4 11.1 0.022 14.1 11.1 1.1 1 0 0 1 1 1 0 BUD22 DUF4598 PF15370.6 ETO33926.1 - 0.046 14.2 7.1 0.077 13.5 7.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4598) TRAP_alpha PF03896.16 ETO33926.1 - 0.38 9.9 4.5 0.48 9.6 4.5 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit NOA36 PF06524.12 ETO33926.1 - 1.2 8.4 13.6 2 7.7 13.6 1.4 1 0 0 1 1 1 0 NOA36 protein Presenilin PF01080.17 ETO33926.1 - 6.9 5.3 6.2 6.8 5.3 6.2 1.1 1 0 0 1 1 1 0 Presenilin F-box PF00646.33 ETO33927.1 - 0.0032 17.3 0.2 0.0094 15.8 0.0 1.9 2 0 0 2 2 2 1 F-box domain FliG_N PF14842.6 ETO33927.1 - 0.018 15.6 0.1 0.042 14.4 0.1 1.6 1 0 0 1 1 1 0 FliG N-terminal domain F-box-like PF12937.7 ETO33927.1 - 0.028 14.3 0.0 0.06 13.3 0.0 1.6 1 0 0 1 1 1 0 F-box-like MecA_N PF05223.11 ETO33927.1 - 0.065 13.5 0.0 0.27 11.5 0.0 1.8 2 0 0 2 2 2 0 NTF2-like N-terminal transpeptidase domain HrpJ PF07201.11 ETO33927.1 - 1 9.6 4.7 0.15 12.4 0.7 1.6 2 0 0 2 2 2 0 HrpJ-like domain Pkinase PF00069.25 ETO33928.1 - 7.5e-05 22.2 0.0 0.00016 21.2 0.0 1.5 1 0 0 1 1 1 1 Protein kinase domain Pkinase PF00069.25 ETO33929.1 - 2.3e-31 109.1 0.2 6.9e-19 68.2 0.0 3.1 3 0 0 3 3 3 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO33929.1 - 7.2e-26 91.0 0.0 3.8e-17 62.4 0.0 2.8 3 0 0 3 3 3 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO33929.1 - 7.9e-05 21.8 0.1 0.00019 20.5 0.0 1.6 2 0 0 2 2 2 1 Haspin like kinase domain Kinase-like PF14531.6 ETO33929.1 - 0.008 15.5 0.1 0.82 8.9 0.0 2.3 2 0 0 2 2 2 2 Kinase-like Pkinase_fungal PF17667.1 ETO33929.1 - 0.046 12.5 0.0 0.077 11.8 0.0 1.3 1 0 0 1 1 1 0 Fungal protein kinase Kdo PF06293.14 ETO33929.1 - 0.096 12.0 2.5 0.062 12.6 0.6 1.6 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO33929.1 - 0.25 11.2 0.1 0.43 10.5 0.1 1.3 1 0 0 1 1 1 0 Phosphotransferase enzyme family VWA_3 PF13768.6 ETO33931.1 - 0.0033 17.4 0.0 1.9 8.4 0.0 2.2 2 0 0 2 2 2 2 von Willebrand factor type A domain VWA PF00092.28 ETO33931.1 - 0.05 13.8 0.1 0.34 11.1 0.1 1.9 1 1 0 1 1 1 0 von Willebrand factor type A domain Med25_VWA PF11265.8 ETO33931.1 - 0.057 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A WD40 PF00400.32 ETO33932.1 - 1.1e-37 127.3 24.3 2.1e-06 28.3 0.1 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33932.1 - 6.8e-13 48.7 1.6 0.035 14.4 0.0 5.9 4 1 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO33932.1 - 7.9e-11 41.3 7.8 0.081 11.6 0.0 6.0 1 1 4 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33932.1 - 1.5e-07 31.0 7.5 0.0006 19.2 0.3 3.9 2 2 1 4 4 4 2 WD40-like domain WD40 PF00400.32 ETO33936.1 - 7.8e-22 77.2 10.3 1.1e-07 32.4 0.4 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33936.1 - 4.3e-06 26.9 0.0 0.049 13.9 0.0 2.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO33936.1 - 0.00034 20.0 0.8 0.012 15.0 0.3 2.1 2 0 0 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO33936.1 - 0.0018 17.0 0.7 1.3 7.6 0.1 3.0 1 1 1 3 3 3 2 Nucleoporin Nup120/160 E_raikovi_mat PF06360.11 ETO33936.1 - 0.0064 16.9 1.4 0.078 13.4 0.2 2.7 3 0 0 3 3 3 1 Euplotes raikovi mating pheromone DUF1840 PF08895.11 ETO33937.1 - 0.12 12.7 3.4 0.19 12.1 3.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) DUF4446 PF14584.6 ETO33937.1 - 0.18 11.8 5.0 0.31 11.0 5.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4446) WD40 PF00400.32 ETO33938.1 - 2.4e-41 138.9 20.0 4.7e-09 36.7 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33938.1 - 2.4e-13 50.2 0.5 0.0095 16.2 0.0 5.0 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33938.1 - 2.1e-07 30.3 2.9 0.42 9.5 0.2 5.4 1 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO33938.1 - 5.2e-06 26.5 0.0 0.00055 19.9 0.0 2.7 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO33938.1 - 2.6e-05 23.1 5.0 0.084 11.5 0.1 3.7 2 1 2 5 5 5 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33938.1 - 3.5e-05 23.3 1.8 0.018 14.4 0.0 3.3 2 1 0 3 3 3 1 WD40-like domain PQQ_2 PF13360.6 ETO33938.1 - 0.00027 20.6 0.0 0.0014 18.3 0.0 2.0 1 1 0 1 1 1 1 PQQ-like domain BBS2_Mid PF14783.6 ETO33938.1 - 0.1 12.6 0.3 18 5.4 0.0 3.8 3 1 0 3 3 3 0 Ciliary BBSome complex subunit 2, middle region DPPIV_N PF00930.21 ETO33938.1 - 0.11 11.2 0.2 10 4.8 0.0 2.7 1 1 2 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Frtz PF11768.8 ETO33938.1 - 0.18 10.0 2.0 0.46 8.7 0.1 2.5 3 1 1 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz Ntox5 PF15543.6 ETO33941.1 - 0.061 13.2 0.5 0.073 12.9 0.5 1.1 1 0 0 1 1 1 0 Bacterial toxin 5 zf-TRAF PF02176.18 ETO33942.1 - 3.7e-07 30.7 3.9 1.3e-06 29.0 3.9 2.0 1 0 0 1 1 1 1 TRAF-type zinc finger zf-TRAF_2 PF15965.5 ETO33942.1 - 0.056 13.9 6.5 0.14 12.7 1.2 2.4 1 1 1 2 2 2 0 TRAF-like zinc-finger DUF4407 PF14362.6 ETO33942.1 - 0.25 10.6 7.2 0.34 10.2 7.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) SAB PF04382.13 ETO33942.1 - 0.3 11.2 6.6 0.06 13.4 2.3 2.1 2 0 0 2 2 2 0 SAB domain CT47 PF15623.6 ETO33942.1 - 1 9.1 6.2 1.9 8.2 6.2 1.4 1 0 0 1 1 1 0 Cancer/testis gene family 47 CAP_N PF01213.19 ETO33943.1 - 6.9e-15 55.3 0.2 6.4e-14 52.2 0.0 1.9 2 0 0 2 2 2 1 Adenylate cyclase associated (CAP) N terminal NPA PF16469.5 ETO33943.1 - 1.4 9.5 6.0 8 7.1 4.8 2.6 1 1 1 2 2 2 0 Nematode polyprotein allergen ABA-1 Apis_Csd PF11671.8 ETO33944.1 - 0.041 13.9 9.4 0.53 10.3 8.8 2.1 2 0 0 2 2 2 0 Complementary sex determiner protein Menin PF05053.13 ETO33944.1 - 0.18 10.2 1.3 0.2 10.0 1.3 1.1 1 0 0 1 1 1 0 Menin Orf78 PF06024.12 ETO33944.1 - 1.8 8.9 5.4 3.4 8.0 5.4 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Secretin_N_2 PF07655.13 ETO33944.1 - 2.3 8.8 11.1 4.8 7.8 11.1 1.4 1 0 0 1 1 1 0 Secretin N-terminal domain Ras PF00071.22 ETO33945.1 - 1.6e-35 122.1 3.1 1.1e-25 90.1 0.2 2.6 3 0 0 3 3 3 2 Ras family Roc PF08477.13 ETO33945.1 - 1.7e-18 66.9 0.1 9.1e-08 32.3 0.0 2.8 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO33945.1 - 1.6e-10 40.8 6.5 8.1e-07 28.7 0.1 3.1 3 0 0 3 3 3 2 ADP-ribosylation factor family YqaH PF17448.2 ETO33945.1 - 0.0022 18.3 0.2 0.0045 17.3 0.2 1.5 1 0 0 1 1 1 1 Uncharacterized YqaH-like TsaE PF02367.17 ETO33945.1 - 0.073 13.1 0.3 0.26 11.3 0.0 1.9 1 1 1 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Cortexin PF11057.8 ETO33945.1 - 0.078 12.8 1.7 0.22 11.4 1.7 1.7 1 0 0 1 1 1 0 Cortexin of kidney Exo_endo_phos PF03372.23 ETO33946.1 - 1.3e-05 24.8 1.3 0.0001 21.9 1.3 2.2 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Exo_endo_phos_2 PF14529.6 ETO33946.1 - 0.018 14.9 1.8 0.059 13.2 1.8 1.9 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase FAA_hydrolase_N PF09298.11 ETO33948.1 - 1.9e-21 76.3 0.0 2.4e-21 75.9 0.0 1.1 1 0 0 1 1 1 1 Fumarylacetoacetase N-terminal Tmemb_18A PF09771.9 ETO33952.1 - 0.75 10.2 6.4 0.57 10.6 0.9 3.2 2 1 1 3 3 3 0 Transmembrane protein 188 Neur_chan_memb PF02932.16 ETO33953.1 - 0.0089 16.1 0.4 0.014 15.4 0.4 1.4 1 0 0 1 1 1 1 Neurotransmitter-gated ion-channel transmembrane region Presenilin PF01080.17 ETO33953.1 - 0.04 12.7 4.0 0.059 12.1 4.0 1.4 1 0 0 1 1 1 0 Presenilin RabGAP-TBC PF00566.18 ETO33953.1 - 0.051 13.2 10.1 2 8.0 0.0 3.5 3 0 0 3 3 3 0 Rab-GTPase-TBC domain Menin PF05053.13 ETO33953.1 - 1.5 7.1 13.5 2.1 6.6 13.5 1.2 1 0 0 1 1 1 0 Menin ALMT PF11744.8 ETO33953.1 - 4.5 6.0 6.9 6.8 5.4 6.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter NST1 PF13945.6 ETO33953.1 - 4.6 7.3 23.4 13 5.9 23.4 1.8 1 0 0 1 1 1 0 Salt tolerance down-regulator HEAT PF02985.22 ETO33955.1 - 7.3e-15 53.8 0.1 0.028 14.6 0.0 6.3 6 0 0 6 6 6 3 HEAT repeat HEAT_2 PF13646.6 ETO33955.1 - 2.4e-11 43.9 0.0 0.00092 19.6 0.0 3.5 3 1 1 4 4 3 3 HEAT repeats HEAT_EZ PF13513.6 ETO33955.1 - 1.4e-05 25.4 0.0 0.19 12.3 0.0 2.7 2 0 0 2 2 2 2 HEAT-like repeat Cnd1 PF12717.7 ETO33955.1 - 5.2e-05 23.4 12.9 0.16 12.0 0.7 3.9 2 2 1 3 3 3 3 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 ETO33955.1 - 0.00017 21.2 0.9 0.0048 16.5 0.1 2.7 1 1 2 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II IFRD PF05004.13 ETO33955.1 - 0.00029 20.0 0.9 0.02 14.0 0.1 2.6 2 1 1 3 3 3 1 Interferon-related developmental regulator (IFRD) CLASP_N PF12348.8 ETO33955.1 - 0.00033 20.3 3.5 0.053 13.1 0.9 2.8 1 1 0 2 2 2 2 CLASP N terminal Dopey_N PF04118.14 ETO33955.1 - 0.0025 17.0 9.4 0.042 13.0 0.2 3.3 1 1 3 4 4 4 2 Dopey, N-terminal N_Asn_amidohyd PF14736.6 ETO33955.1 - 0.0029 16.8 1.7 0.015 14.5 0.1 2.3 2 0 0 2 2 2 1 Protein N-terminal asparagine amidohydrolase DUF2222 PF09984.9 ETO33955.1 - 0.009 15.9 0.3 2.3 8.1 0.2 2.6 2 0 0 2 2 2 1 Uncharacterised signal transduction histidine kinase domain (DUF2222) MMS19_C PF12460.8 ETO33955.1 - 0.0093 15.1 1.7 0.0093 15.1 1.7 2.3 1 1 0 2 2 2 1 RNAPII transcription regulator C-terminal TIP120 PF08623.10 ETO33955.1 - 0.011 15.5 6.7 1.1 9.1 0.0 4.0 2 2 2 4 4 4 0 TATA-binding protein interacting (TIP20) SAC3_GANP PF03399.16 ETO33955.1 - 0.017 14.5 3.1 0.14 11.5 0.2 3.2 2 2 2 4 4 4 0 SAC3/GANP family Gcn1_N PF12074.8 ETO33955.1 - 0.021 14.1 0.0 0.97 8.7 0.0 2.2 2 0 0 2 2 2 0 Generalcontrol nonderepressible 1 (Gcn1) N-terminal DUF1539 PF07560.11 ETO33955.1 - 0.057 13.5 2.5 0.2 11.7 0.8 2.4 2 0 0 2 2 2 0 Domain of Unknown Function (DUF1539) ThiI PF02568.14 ETO33955.1 - 0.11 12.0 0.2 0.51 9.9 0.2 2.0 2 0 0 2 2 2 0 Thiamine biosynthesis protein (ThiI) HEAT_PBS PF03130.16 ETO33955.1 - 0.13 13.1 0.0 51 5.0 0.0 3.9 4 0 0 4 4 4 0 PBS lyase HEAT-like repeat UPF0147 PF03685.13 ETO33955.1 - 1.3 9.1 3.8 55 3.9 0.0 4.1 2 2 4 6 6 6 0 Uncharacterised protein family (UPF0147) CCDC-167 PF15188.6 ETO33955.1 - 1.6 9.1 7.4 15 6.0 0.1 4.2 3 3 0 3 3 3 0 Coiled-coil domain-containing protein 167 NLE PF08154.12 ETO33955.1 - 1.9 9.1 7.4 13 6.4 0.2 4.4 3 2 3 6 6 4 0 NLE (NUC135) domain Myc_N PF01056.18 ETO33956.1 - 0.31 10.9 8.4 0.31 10.9 8.4 1.0 1 0 0 1 1 1 0 Myc amino-terminal region Dynactin_p62 PF05502.13 ETO33956.1 - 1.9 7.2 10.9 1.9 7.1 10.9 1.0 1 0 0 1 1 1 0 Dynactin p62 family DUF4181 PF13789.6 ETO33957.1 - 2.9 8.2 17.7 2.6 8.3 0.2 3.4 3 0 0 3 3 3 0 Domain of unknown function (DUF4181) DUF3195 PF11424.8 ETO33958.1 - 0.013 15.6 0.4 0.042 13.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3195) Papo_T_antigen PF02380.15 ETO33958.1 - 2.2 8.5 8.0 0.14 12.3 1.2 2.3 3 0 0 3 3 3 0 T-antigen specific domain Cnd1 PF12717.7 ETO33960.1 - 0.069 13.2 0.3 0.069 13.2 0.3 2.1 1 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 DS PF01916.17 ETO33960.1 - 0.088 12.0 0.1 0.18 11.0 0.1 1.5 1 0 0 1 1 1 0 Deoxyhypusine synthase RAC_head PF16717.5 ETO33960.1 - 0.089 13.8 4.7 6 7.9 0.4 3.2 3 0 0 3 3 3 0 Ribosome-associated complex head domain SMN PF06003.12 ETO33961.1 - 0.24 10.6 11.1 0.26 10.5 11.1 1.2 1 0 0 1 1 1 0 Survival motor neuron protein (SMN) Phage_Gp23 PF10669.9 ETO33962.1 - 0.0004 20.7 2.5 0.00049 20.4 2.5 1.1 1 0 0 1 1 1 1 Protein gp23 (Bacteriophage A118) DUF4834 PF16118.5 ETO33962.1 - 0.0023 18.9 3.8 0.0052 17.7 3.8 1.7 1 1 0 1 1 1 1 Domain of unknown function (DUF4834) FPN1 PF06963.12 ETO33962.1 - 0.012 14.2 0.3 0.014 14.0 0.3 1.0 1 0 0 1 1 1 0 Ferroportin1 (FPN1) YMF19 PF02326.15 ETO33962.1 - 0.022 15.5 5.6 0.032 15.0 5.1 1.7 1 1 0 1 1 1 0 Plant ATP synthase F0 7tm_1 PF00001.21 ETO33962.1 - 0.026 13.8 0.9 0.025 13.9 0.9 1.1 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) YebO PF13974.6 ETO33962.1 - 1.8 8.7 5.9 8.8 6.5 2.2 2.4 2 1 0 2 2 2 0 YebO-like protein ETRAMP PF09716.10 ETO33962.1 - 3.1 7.9 9.4 4.6 7.4 8.8 1.7 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) RGS PF00615.19 ETO33964.1 - 1.3e-05 25.4 0.0 3.8e-05 23.9 0.0 1.8 1 0 0 1 1 1 1 Regulator of G protein signaling domain NAD_binding_5 PF07994.12 ETO33965.1 - 5.5e-135 449.9 0.0 6.5e-135 449.6 0.0 1.1 1 0 0 1 1 1 1 Myo-inositol-1-phosphate synthase Inos-1-P_synth PF01658.17 ETO33965.1 - 8.2e-46 154.8 0.3 8.2e-46 154.8 0.3 1.9 2 0 0 2 2 2 1 Myo-inositol-1-phosphate synthase Tetraspanin PF00335.20 ETO33965.1 - 0.056 13.1 0.4 0.056 13.1 0.4 2.1 2 1 0 2 2 2 0 Tetraspanin family DUF3290 PF11694.8 ETO33965.1 - 0.18 11.8 2.0 0.17 11.8 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3290) PPR_2 PF13041.6 ETO33967.1 - 4.4e-17 62.0 11.4 1.3e-07 31.7 0.1 5.9 5 1 2 7 7 7 4 PPR repeat family PPR PF01535.20 ETO33967.1 - 4.7e-17 61.0 1.9 0.0045 17.1 0.0 4.9 4 0 0 4 4 4 4 PPR repeat PPR_1 PF12854.7 ETO33967.1 - 1.6e-12 46.9 3.1 0.0022 17.7 0.0 4.5 4 0 0 4 4 4 4 PPR repeat PPR_3 PF13812.6 ETO33967.1 - 2.4e-07 30.7 5.6 8e-05 22.6 0.4 5.2 5 1 2 7 7 7 3 Pentatricopeptide repeat domain PPR_long PF17177.4 ETO33967.1 - 3.7e-06 26.5 0.6 1.2e-05 24.8 0.6 1.9 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO33967.1 - 0.0011 18.8 0.9 0.018 14.9 0.0 3.3 2 1 1 3 3 3 1 Mitochondrial ATPase expression Peptidase_M24_C PF16188.5 ETO33967.1 - 0.088 12.9 0.6 0.33 11.0 0.1 2.3 2 0 0 2 2 2 0 C-terminal region of peptidase_M24 Adeno_52K PF03052.15 ETO33967.1 - 0.16 11.4 2.0 1.5 8.2 0.0 2.3 2 0 0 2 2 2 0 Adenoviral protein L1 52/55-kDa LAGLIDADG_WhiA PF14527.6 ETO33967.1 - 1.9 8.6 6.0 7.5 6.7 0.1 2.9 3 0 0 3 3 3 0 WhiA LAGLIDADG-like domain CAF1 PF04857.20 ETO33968.1 - 5.7e-15 55.3 15.2 1.1e-08 34.6 0.0 3.8 2 1 0 3 3 3 2 CAF1 family ribonuclease CPSF100_C PF13299.6 ETO33968.1 - 0.26 11.4 7.4 1.6 8.9 0.8 2.3 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal RPA43_OB PF17875.1 ETO33968.1 - 0.31 11.7 11.6 1.6 9.4 0.4 2.4 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I DUF5308 PF17233.2 ETO33968.1 - 0.32 11.2 4.8 4.4 7.5 0.8 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5308) RNA_pol_Rpc4 PF05132.14 ETO33968.1 - 0.38 11.2 9.5 3.4 8.1 2.8 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 CLN3 PF02487.17 ETO33968.1 - 0.4 9.7 3.7 1.8 7.5 0.4 2.1 2 0 0 2 2 2 0 CLN3 protein GNAT_acetyltr_2 PF13718.6 ETO33968.1 - 0.44 9.9 10.5 0.78 9.1 1.6 2.4 2 0 0 2 2 2 0 GNAT acetyltransferase 2 Zip PF02535.22 ETO33968.1 - 0.68 9.1 8.6 3.2 6.9 0.8 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter Presenilin PF01080.17 ETO33968.1 - 0.88 8.3 12.8 1.2 7.8 2.3 2.1 2 0 0 2 2 2 0 Presenilin Secretin_N_2 PF07655.13 ETO33968.1 - 0.95 10.1 22.0 0.55 10.8 13.6 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain POX PF07526.11 ETO33968.1 - 1.8 9.1 12.8 2.1 8.9 1.2 2.3 2 0 0 2 2 2 0 Associated with HOX Peroxin-13_N PF04088.13 ETO33968.1 - 3.3 8.0 5.2 6.4 7.0 0.2 2.5 2 0 0 2 2 2 0 Peroxin 13, N-terminal region NST1 PF13945.6 ETO33968.1 - 3.4 7.7 27.5 0.11 12.6 10.8 2.4 2 0 0 2 2 2 0 Salt tolerance down-regulator Methyltransf_32 PF13679.6 ETO33968.1 - 5.5 7.0 12.0 0.79 9.7 1.8 2.8 3 0 0 3 3 3 0 Methyltransferase domain CAF1 PF04857.20 ETO33969.1 - 3.6e-15 56.0 1.0 3.6e-15 56.0 1.0 1.8 2 1 0 2 2 2 1 CAF1 family ribonuclease PNPase PF03726.14 ETO33969.1 - 0.16 12.5 0.4 0.46 11.0 0.4 1.7 1 0 0 1 1 1 0 Polyribonucleotide nucleotidyltransferase, RNA binding domain Methyltrn_RNA_4 PF09936.9 ETO33970.1 - 0.08 12.8 0.2 0.16 11.8 0.2 1.4 1 0 0 1 1 1 0 SAM-dependent RNA methyltransferase TACC_C PF05010.14 ETO33971.1 - 0.0011 18.8 11.2 0.084 12.7 4.4 2.5 1 1 1 2 2 2 2 Transforming acidic coiled-coil-containing protein (TACC), C-terminal DUF641 PF04859.12 ETO33971.1 - 0.0016 18.7 3.8 0.0016 18.7 3.8 2.0 2 0 0 2 2 2 1 Plant protein of unknown function (DUF641) DUF5082 PF16888.5 ETO33971.1 - 0.0067 16.7 12.9 0.012 15.8 12.9 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF5082) DUF5390 PF17365.2 ETO33971.1 - 0.012 15.9 0.1 0.022 15.0 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5390) TSC22 PF01166.18 ETO33971.1 - 0.014 15.7 5.8 0.69 10.3 0.7 2.7 2 0 0 2 2 2 0 TSC-22/dip/bun family NPV_P10 PF05531.12 ETO33971.1 - 0.017 15.6 4.0 0.017 15.6 4.0 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein bZIP_1 PF00170.21 ETO33971.1 - 0.03 14.4 8.4 0.94 9.6 1.0 2.7 2 0 0 2 2 2 0 bZIP transcription factor Snapin_Pallidin PF14712.6 ETO33971.1 - 0.031 14.7 4.3 0.031 14.7 4.3 2.1 1 1 1 2 2 2 0 Snapin/Pallidin PKcGMP_CC PF16808.5 ETO33971.1 - 0.059 13.2 0.1 0.059 13.2 0.1 3.2 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4407 PF14362.6 ETO33971.1 - 0.083 12.2 4.2 0.11 11.8 4.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DUF4050 PF13259.6 ETO33971.1 - 0.21 11.9 1.8 0.29 11.4 1.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF4050) TMF_DNA_bd PF12329.8 ETO33971.1 - 0.25 11.4 16.9 0.7 9.9 7.0 2.4 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding Tropomyosin_1 PF12718.7 ETO33971.1 - 0.26 11.4 15.1 7.2 6.8 15.3 2.1 1 1 1 2 2 2 0 Tropomyosin like DUF4145 PF13643.6 ETO33971.1 - 0.33 11.1 4.4 2.1 8.5 0.3 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4145) BST2 PF16716.5 ETO33971.1 - 1.2 9.7 12.5 0.27 11.9 4.9 2.5 2 1 0 2 2 2 0 Bone marrow stromal antigen 2 DivIC PF04977.15 ETO33971.1 - 1.3 8.8 11.6 2 8.2 4.3 2.5 2 0 0 2 2 2 0 Septum formation initiator CENP-F_leu_zip PF10473.9 ETO33971.1 - 1.4 8.9 16.0 3.1 7.8 10.6 2.2 1 1 1 2 2 2 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ABC_tran_CTD PF16326.5 ETO33971.1 - 1.8 8.8 8.6 82 3.6 8.4 2.8 1 1 0 1 1 1 0 ABC transporter C-terminal domain CHD5 PF04420.14 ETO33971.1 - 2.5 8.0 5.7 2.2 8.1 2.1 2.1 2 0 0 2 2 2 0 CHD5-like protein Mt_ATP-synt_D PF05873.12 ETO33971.1 - 2.7 7.8 9.8 7 6.5 0.2 2.1 1 1 1 2 2 2 0 ATP synthase D chain, mitochondrial (ATP5H) TSNAXIP1_N PF15739.5 ETO33971.1 - 3.8 7.9 11.9 3.1 8.2 7.2 2.4 2 1 0 2 2 2 0 Translin-associated factor X-interacting N-terminus WD40 PF00400.32 ETO33972.1 - 5.3e-09 36.6 6.6 1.1e-07 32.5 0.1 4.1 4 0 0 4 4 4 1 WD domain, G-beta repeat DUF484 PF04340.12 ETO33972.1 - 0.1 12.3 0.3 0.2 11.3 0.3 1.4 1 0 0 1 1 1 0 Protein of unknown function, DUF484 DUF4820 PF16091.5 ETO33972.1 - 0.4 10.0 9.4 0.55 9.5 9.0 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4820) CagX PF03524.15 ETO33972.1 - 0.88 9.2 3.9 0.84 9.3 0.2 2.3 2 0 0 2 2 2 0 Conjugal transfer protein EIIBC-GUT_N PF03612.14 ETO33972.1 - 4 7.1 9.8 4.3 7.0 3.6 2.7 3 0 0 3 3 3 0 Sorbitol phosphotransferase enzyme II N-terminus POPLD PF08170.12 ETO33973.1 - 0.05 14.0 0.8 0.18 12.2 0.0 2.3 2 0 0 2 2 2 0 POPLD (NUC188) domain Cytochrom_B561 PF03188.16 ETO33974.1 - 9.3e-05 22.6 15.7 0.00044 20.4 15.7 1.9 1 1 0 1 1 1 1 Eukaryotic cytochrome b561 Mg_trans_NIPA PF05653.14 ETO33975.1 - 0.041 13.0 0.1 0.06 12.4 0.1 1.1 1 0 0 1 1 1 0 Magnesium transporter NIPA DUF3439 PF11921.8 ETO33976.1 - 3.6 7.6 7.6 4.9 7.1 3.7 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF3439) DUF3232 PF11554.8 ETO33977.1 - 0.037 14.4 0.2 0.083 13.3 0.1 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF3232) zf-TRAF PF02176.18 ETO33978.1 - 0.014 16.1 1.2 0.05 14.3 0.0 2.5 2 0 0 2 2 2 0 TRAF-type zinc finger DUF723 PF05265.13 ETO33978.1 - 0.11 12.4 1.7 12 5.9 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF723) zf-C3HC4_2 PF13923.6 ETO33978.1 - 0.22 11.4 7.4 1.3 8.9 4.3 3.4 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO33978.1 - 3.6 8.0 8.0 2.1 8.8 3.1 3.0 2 1 1 3 3 3 0 Ring finger domain Peptidase_C14 PF00656.22 ETO33979.1 - 0.0029 17.6 0.0 0.016 15.2 0.0 1.9 1 1 0 1 1 1 1 Caspase domain DUF3052 PF11253.8 ETO33981.1 - 0.03 14.3 0.4 0.054 13.4 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3052) Phasin PF05597.11 ETO33982.1 - 0.08 13.0 3.5 1.6 8.7 1.5 2.8 1 1 2 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF2115 PF09888.9 ETO33982.1 - 1.9 9.0 8.0 6.9 7.2 0.2 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in archaea (DUF2115) Nop14 PF04147.12 ETO33983.1 - 0.00018 19.9 68.2 0.00018 19.9 68.2 1.8 2 0 0 2 2 2 1 Nop14-like family LAP1C PF05609.12 ETO33983.1 - 0.83 8.7 20.8 1.1 8.2 20.8 1.2 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) WD40 PF00400.32 ETO33985.1 - 3.8e-32 109.8 10.5 6.4e-10 39.5 0.1 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO33985.1 - 2e-14 53.6 0.4 7.6e-06 26.1 0.1 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO33985.1 - 4.1e-07 29.3 0.0 0.0044 16.0 0.0 3.0 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO33985.1 - 4.4e-07 30.0 0.1 4.6e-05 23.4 0.0 1.8 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO33985.1 - 2e-05 23.5 1.0 0.26 9.9 0.1 3.3 1 1 2 4 4 4 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO33985.1 - 3.6e-05 23.2 0.3 0.22 10.8 0.1 2.4 1 1 1 2 2 2 2 WD40-like domain DUF5474 PF17568.2 ETO33985.1 - 0.00054 20.0 0.1 0.63 10.1 0.0 2.7 1 1 1 3 3 3 2 Family of unknown function (DUF5474) PALB2_WD40 PF16756.5 ETO33985.1 - 0.0057 15.6 1.4 0.93 8.4 0.0 3.0 1 1 1 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO33985.1 - 0.056 13.5 0.8 2.7 8.1 0.1 2.7 1 1 2 3 3 3 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO33985.1 - 0.069 13.1 0.0 5.1 7.2 0.0 2.6 2 0 0 2 2 2 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO33985.1 - 0.079 11.7 3.0 4.7 5.9 0.6 3.0 1 1 1 2 2 2 0 Nup133 N terminal like DUF4072 PF13284.6 ETO33985.1 - 0.2 12.1 0.0 0.99 9.9 0.0 2.2 3 0 0 3 3 3 0 Domain of unknown function (DUF4072) DUF4999 PF16390.5 ETO33985.1 - 1.7 8.9 3.9 53 4.1 0.2 3.1 2 1 1 3 3 3 0 Domain of unknown function GOLD_2 PF13897.6 ETO33986.1 - 0.05 14.1 1.0 0.079 13.5 0.2 1.8 1 1 1 2 2 2 0 Golgi-dynamics membrane-trafficking COX14 PF14880.6 ETO33988.1 - 0.15 11.9 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Cytochrome oxidase c assembly Orf78 PF06024.12 ETO33988.1 - 0.6 10.4 2.4 5.1 7.4 0.1 2.6 3 0 0 3 3 3 0 Orf78 (ac78) Cgr1 PF03879.14 ETO33990.1 - 2 8.8 13.1 0.37 11.2 8.5 2.2 2 0 0 2 2 2 0 Cgr1 family AP_endonuc_2_N PF07582.12 ETO33991.1 - 0.14 11.9 0.0 0.25 11.1 0.0 1.4 1 0 0 1 1 1 0 AP endonuclease family 2 C terminus NACHT PF05729.12 ETO33993.1 - 1.3e-12 48.0 0.0 6.8e-11 42.4 0.0 2.2 1 1 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO33993.1 - 2.4e-05 23.7 0.4 0.00078 18.7 0.2 2.7 2 1 1 3 3 3 1 NB-ARC domain AAA_16 PF13191.6 ETO33993.1 - 0.0015 18.9 0.0 0.012 16.0 0.0 2.0 1 1 0 2 2 2 1 AAA ATPase domain RNA_helicase PF00910.22 ETO33993.1 - 0.0068 16.8 2.9 0.074 13.4 0.1 2.6 2 1 0 2 2 2 1 RNA helicase ATPase PF06745.13 ETO33993.1 - 0.017 14.5 0.1 0.051 12.9 0.1 1.8 1 1 0 1 1 1 0 KaiC AAA PF00004.29 ETO33993.1 - 0.02 15.3 0.0 0.037 14.5 0.0 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO33993.1 - 0.047 13.2 0.2 0.15 11.5 0.0 1.8 2 0 0 2 2 2 0 P-loop containing dynein motor region AAA_22 PF13401.6 ETO33993.1 - 0.1 12.9 0.1 0.37 11.1 0.1 2.1 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO33993.1 - 0.14 11.8 0.1 0.92 9.2 0.0 2.0 1 1 1 2 2 2 0 AAA domain Ribosomal_L6 PF00347.23 ETO33994.1 - 8.5e-13 48.8 0.7 5.9e-05 23.7 0.0 3.4 2 1 0 2 2 2 2 Ribosomal protein L6 CAP_GLY PF01302.25 ETO33996.1 - 1.9e-07 31.0 2.5 0.075 13.1 0.1 3.4 1 1 2 3 3 3 3 CAP-Gly domain DUF2452 PF10504.9 ETO33997.1 - 0.67 9.4 7.1 1.4 8.4 4.7 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2452) DUF4200 PF13863.6 ETO33997.1 - 0.9 10.0 14.1 0.17 12.3 9.4 2.2 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) DUF1676 PF07898.13 ETO33998.1 - 3.4e-06 27.2 8.2 4e-06 27.0 8.2 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1676) DUF2615 PF11027.8 ETO33998.1 - 0.014 15.6 1.3 0.017 15.2 1.3 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) HlyD_2 PF12700.7 ETO33998.1 - 3.8 6.1 10.6 4.8 5.8 10.6 1.1 1 0 0 1 1 1 0 HlyD family secretion protein HEAT PF02985.22 ETO33999.1 - 0.013 15.7 0.1 1.7 9.2 0.1 2.5 2 0 0 2 2 2 0 HEAT repeat HEAT PF02985.22 ETO34000.1 - 0.024 14.9 0.1 0.15 12.4 0.0 2.3 2 0 0 2 2 2 0 HEAT repeat KilA-N PF04383.13 ETO34001.1 - 0.0055 16.5 0.1 0.0061 16.4 0.1 1.2 1 0 0 1 1 1 1 KilA-N domain SPT16 PF08644.11 ETO34005.1 - 7.1e-46 156.1 0.0 7.1e-46 156.1 0.0 3.5 4 0 0 4 4 4 1 FACT complex subunit (SPT16/CDC68) FACT-Spt16_Nlob PF14826.6 ETO34005.1 - 2.4e-29 102.2 0.2 2.4e-29 102.2 0.2 2.6 2 0 0 2 2 2 1 FACT complex subunit SPT16 N-terminal lobe domain Peptidase_M24 PF00557.24 ETO34005.1 - 1.2e-24 87.2 0.0 2.4e-24 86.2 0.0 1.5 1 0 0 1 1 1 1 Metallopeptidase family M24 Rtt106 PF08512.12 ETO34005.1 - 1.9e-16 60.2 0.0 7.8e-16 58.3 0.0 2.1 1 0 0 1 1 1 1 Histone chaperone Rttp106-like Cwf_Cwc_15 PF04889.12 ETO34005.1 - 0.00052 19.8 34.3 0.00052 19.8 34.3 2.6 2 0 0 2 2 2 2 Cwf15/Cwc15 cell cycle control protein BUD22 PF09073.10 ETO34005.1 - 4.7 6.4 57.8 0.038 13.3 31.4 2.5 2 0 0 2 2 2 0 BUD22 SPRY PF00622.28 ETO34007.1 - 5.5e-05 23.3 0.0 8.4e-05 22.7 0.0 1.3 1 0 0 1 1 1 1 SPRY domain DUF190 PF02641.15 ETO34008.1 - 0.08 13.3 0.0 0.14 12.5 0.0 1.3 1 0 0 1 1 1 0 Uncharacterized ACR, COG1993 OB_NTP_bind PF07717.16 ETO34009.1 - 5.3e-22 78.0 0.0 1.6e-21 76.4 0.0 1.8 2 0 0 2 2 2 1 Oligonucleotide/oligosaccharide-binding (OB)-fold HA2 PF04408.23 ETO34009.1 - 9.4e-19 67.7 0.3 3.7e-18 65.8 0.0 2.2 2 0 0 2 2 2 1 Helicase associated domain (HA2) Helicase_C PF00271.31 ETO34009.1 - 3.4e-14 53.1 0.0 1e-13 51.6 0.0 1.9 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO34009.1 - 8e-08 32.2 0.1 4.5e-07 29.8 0.1 2.2 2 1 0 2 2 2 1 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO34009.1 - 3.8e-05 24.0 0.6 0.00027 21.2 0.0 2.4 2 0 0 2 2 2 1 AAA domain AAA_19 PF13245.6 ETO34009.1 - 0.0018 18.6 0.0 0.0056 17.0 0.0 1.8 1 0 0 1 1 1 1 AAA domain Flavi_DEAD PF07652.14 ETO34009.1 - 0.058 13.4 0.0 0.12 12.3 0.0 1.5 1 0 0 1 1 1 0 Flavivirus DEAD domain ResIII PF04851.15 ETO34009.1 - 0.16 11.9 2.2 10 6.1 0.1 3.1 2 1 0 3 3 3 0 Type III restriction enzyme, res subunit UPF0184 PF03670.13 ETO34009.1 - 0.18 12.2 0.5 0.39 11.1 0.5 1.5 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0184) AA_permease PF00324.21 ETO34010.1 - 4.4e-14 51.9 16.0 5.5e-14 51.6 16.0 1.1 1 0 0 1 1 1 1 Amino acid permease HALZ PF02183.18 ETO34010.1 - 2.9e-05 24.2 0.2 4.7e-05 23.5 0.2 1.3 1 0 0 1 1 1 1 Homeobox associated leucine zipper DUF2207 PF09972.9 ETO34010.1 - 0.0022 16.9 0.2 0.0028 16.5 0.1 1.3 1 1 0 1 1 1 1 Predicted membrane protein (DUF2207) Taxilin PF09728.9 ETO34010.1 - 0.045 12.9 1.2 0.056 12.6 1.2 1.0 1 0 0 1 1 1 0 Myosin-like coiled-coil protein AA_permease_2 PF13520.6 ETO34010.1 - 0.12 11.1 15.7 0.15 10.8 15.7 1.1 1 0 0 1 1 1 0 Amino acid permease Bap31_Bap29_C PF18035.1 ETO34010.1 - 0.21 11.6 3.9 2.7 8.1 3.9 2.3 1 1 0 1 1 1 0 Bap31/Bap29 cytoplasmic coiled-coil domain bZIP_1 PF00170.21 ETO34010.1 - 0.24 11.5 0.1 0.41 10.8 0.1 1.3 1 0 0 1 1 1 0 bZIP transcription factor PUF PF00806.19 ETO34011.1 - 2e-29 99.6 11.2 3.2e-06 26.5 0.1 6.4 6 0 0 6 6 6 6 Pumilio-family RNA binding repeat Importin_rep_3 PF18806.1 ETO34011.1 - 0.09 12.8 0.0 22 5.2 0.0 2.9 3 0 0 3 3 3 0 Importin 13 repeat RNA_pol_Rpb1_5 PF04998.17 ETO34012.1 - 2.9e-47 161.3 14.6 1.3e-44 152.6 14.6 2.9 1 1 0 1 1 1 1 RNA polymerase Rpb1, domain 5 Ndc1_Nup PF09531.10 ETO34012.1 - 0.29 9.8 7.0 0.42 9.2 7.0 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup LAP1C PF05609.12 ETO34012.1 - 0.36 9.9 27.2 0.68 9.0 27.2 1.4 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Nop14 PF04147.12 ETO34012.1 - 0.48 8.6 35.7 0.76 7.9 35.7 1.3 1 0 0 1 1 1 0 Nop14-like family GREB1 PF15782.5 ETO34012.1 - 0.72 6.9 20.0 0.93 6.5 20.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer SDA1 PF05285.12 ETO34012.1 - 7.9 5.8 45.0 20 4.5 45.0 1.6 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpb1_5 PF04998.17 ETO34013.1 - 7e-31 107.6 0.0 1e-30 107.1 0.0 1.3 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 5 RNA_pol_Rpb1_4 PF05000.17 ETO34013.1 - 8.7e-22 77.1 0.0 2.6e-21 75.6 0.0 1.9 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 4 RNA_pol_Rpb1_3 PF04983.18 ETO34013.1 - 1.8e-11 44.2 0.0 6.3e-11 42.4 0.0 1.9 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 RNA_pol_Rpb1_2 PF00623.20 ETO34014.1 - 5.3e-42 143.9 0.2 7.3e-42 143.4 0.2 1.2 1 0 0 1 1 1 1 RNA polymerase Rpb1, domain 2 RNA_pol_Rpb1_3 PF04983.18 ETO34014.1 - 6.6e-19 68.4 0.0 1.6e-18 67.2 0.0 1.6 2 0 0 2 2 2 1 RNA polymerase Rpb1, domain 3 zf-RING_5 PF14634.6 ETO34016.1 - 0.078 13.0 0.7 0.078 13.0 0.7 2.8 2 0 0 2 2 2 0 zinc-RING finger domain Atrophin-1 PF03154.15 ETO34018.1 - 2.1 6.5 18.5 0.6 8.3 14.1 2.1 2 0 0 2 2 2 0 Atrophin-1 family EF-hand_14 PF17959.1 ETO34019.1 - 0.11 12.8 1.7 0.74 10.2 0.3 3.0 2 0 0 2 2 2 0 EF-hand domain Topoisom_bac PF01131.20 ETO34020.1 - 7.4e-89 298.6 0.1 2e-88 297.2 0.1 1.6 1 1 0 1 1 1 1 DNA topoisomerase Toprim PF01751.22 ETO34020.1 - 1.1e-13 51.2 0.0 3.5e-12 46.5 0.0 2.5 2 0 0 2 2 2 1 Toprim domain Peptidase_C14 PF00656.22 ETO34021.1 - 1e-09 38.7 3.6 8.5e-09 35.7 3.6 2.1 1 1 0 1 1 1 1 Caspase domain Kelch_5 PF13854.6 ETO34022.1 - 6.7e-06 26.0 0.5 0.0019 18.2 0.2 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_3 PF13415.6 ETO34022.1 - 0.0023 18.2 0.0 0.0043 17.3 0.0 1.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO34022.1 - 0.0094 15.9 0.0 0.33 11.0 0.1 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO34022.1 - 0.032 14.5 0.8 0.087 13.1 0.1 1.9 1 1 1 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO34022.1 - 0.035 14.1 0.2 2.4 8.3 0.1 2.5 2 0 0 2 2 2 0 Kelch motif Kelch_1 PF01344.25 ETO34022.1 - 0.14 11.7 0.0 0.71 9.5 0.1 2.1 2 0 0 2 2 2 0 Kelch motif SOR_SNZ PF01680.17 ETO34023.1 - 6.7e-103 342.9 3.6 9.3e-103 342.4 3.6 1.2 1 0 0 1 1 1 1 SOR/SNZ family ThiG PF05690.14 ETO34023.1 - 3.6e-09 36.3 4.6 3.8e-07 29.7 0.3 2.4 1 1 1 3 3 3 2 Thiazole biosynthesis protein ThiG NMO PF03060.15 ETO34023.1 - 9.7e-06 25.2 3.1 0.005 16.3 0.1 2.3 2 0 0 2 2 2 2 Nitronate monooxygenase Dus PF01207.17 ETO34023.1 - 0.0004 19.6 0.2 0.67 9.0 0.0 2.5 2 1 0 2 2 2 2 Dihydrouridine synthase (Dus) NanE PF04131.14 ETO34023.1 - 0.00098 18.4 0.7 0.019 14.1 0.0 2.6 2 1 0 2 2 2 1 Putative N-acetylmannosamine-6-phosphate epimerase His_biosynth PF00977.21 ETO34023.1 - 0.0018 17.8 0.2 0.0097 15.4 0.0 1.9 2 0 0 2 2 2 1 Histidine biosynthesis protein FMN_dh PF01070.18 ETO34023.1 - 0.0026 16.9 0.6 0.017 14.2 0.0 2.4 3 0 0 3 3 3 1 FMN-dependent dehydrogenase Glu_synthase PF01645.17 ETO34023.1 - 0.0057 15.8 0.0 0.0099 15.0 0.0 1.3 1 0 0 1 1 1 1 Conserved region in glutamate synthase IMPDH PF00478.25 ETO34023.1 - 0.026 13.5 0.1 0.047 12.7 0.1 1.4 1 0 0 1 1 1 0 IMP dehydrogenase / GMP reductase domain ETF PF01012.21 ETO34023.1 - 0.039 13.9 0.3 0.99 9.3 0.1 2.4 2 0 0 2 2 2 0 Electron transfer flavoprotein domain IGPS PF00218.21 ETO34023.1 - 0.055 12.6 0.2 1.1 8.3 0.0 2.4 2 1 0 2 2 2 0 Indole-3-glycerol phosphate synthase DHO_dh PF01180.21 ETO34023.1 - 0.067 12.4 0.0 0.16 11.2 0.0 1.6 2 0 0 2 2 2 0 Dihydroorotate dehydrogenase TetR_C_27 PF17935.1 ETO34023.1 - 0.11 12.5 0.0 1.1 9.3 0.0 2.2 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain DUF2608 PF11019.8 ETO34024.1 - 9.4e-08 31.8 3.9 9.4e-08 31.8 3.9 2.8 1 1 1 2 2 2 1 Protein of unknown function (DUF2608) RRM_1 PF00076.22 ETO34025.1 - 1.3e-09 37.7 2.0 4e-09 36.1 0.1 2.5 3 0 0 3 3 3 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) EMP24_GP25L PF01105.24 ETO34027.1 - 3.7e-10 40.0 0.3 4.7e-10 39.7 0.3 1.0 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD ArlS_N PF18719.1 ETO34027.1 - 0.012 15.8 0.6 0.018 15.3 0.1 1.5 2 0 0 2 2 2 0 ArlS sensor domain DUF4624 PF15417.6 ETO34027.1 - 0.028 14.2 0.1 0.04 13.7 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4624) DUF3244 PF11589.8 ETO34027.1 - 0.029 14.4 0.2 0.05 13.7 0.2 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF3244) GH97_N PF14508.6 ETO34028.1 - 0.0036 16.8 0.1 0.004 16.7 0.1 1.1 1 0 0 1 1 1 1 Glycosyl-hydrolase 97 N-terminal DUF3023 PF11224.8 ETO34028.1 - 0.063 13.1 0.2 0.072 12.9 0.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3023) NACHT PF05729.12 ETO34029.1 - 0.0036 17.2 0.0 0.0049 16.8 0.0 1.1 1 0 0 1 1 1 1 NACHT domain EF-hand_1 PF00036.32 ETO34029.1 - 0.4 10.3 4.4 0.18 11.4 1.5 2.0 2 0 0 2 2 2 0 EF hand NACHT PF05729.12 ETO34030.1 - 0.0002 21.3 0.0 0.00049 20.1 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO34030.1 - 0.0021 18.6 2.0 0.043 14.4 0.0 2.9 3 0 0 3 3 3 1 AAA domain AAA_22 PF13401.6 ETO34030.1 - 0.0022 18.3 0.0 0.0052 17.1 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_5 PF07728.14 ETO34030.1 - 0.011 15.8 0.1 0.27 11.2 0.0 2.7 3 0 0 3 3 3 0 AAA domain (dynein-related subfamily) RsgA_GTPase PF03193.16 ETO34030.1 - 0.02 14.8 0.0 0.031 14.2 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase RNA_helicase PF00910.22 ETO34030.1 - 0.025 15.0 0.0 0.07 13.5 0.0 1.8 1 0 0 1 1 1 0 RNA helicase Zeta_toxin PF06414.12 ETO34030.1 - 0.031 13.6 0.0 0.054 12.8 0.0 1.3 1 0 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.26 ETO34030.1 - 0.031 14.0 0.0 0.16 11.7 0.0 1.9 2 0 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 ETO34030.1 - 0.031 14.3 0.0 0.14 12.2 0.0 1.9 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETO34030.1 - 0.11 12.9 0.0 0.35 11.2 0.0 1.8 2 0 0 2 2 2 0 AAA ATPase domain RRM_1 PF00076.22 ETO34031.1 - 0.0017 18.2 0.0 0.44 10.4 0.0 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRP7 PF12923.7 ETO34031.1 - 0.013 15.6 6.3 0.013 15.6 6.3 1.9 2 0 0 2 2 2 0 Ribosomal RNA-processing protein 7 (RRP7) C-terminal domain Kelch_1 PF01344.25 ETO34032.1 - 0.00021 20.8 0.2 0.0012 18.4 0.1 2.0 2 0 0 2 2 2 1 Kelch motif FOXP-CC PF16159.5 ETO34033.1 - 0.00083 19.9 0.6 0.0022 18.6 0.6 1.7 1 0 0 1 1 1 1 FOXP coiled-coil domain zf-H2C2_2 PF13465.6 ETO34033.1 - 0.1 13.0 0.8 0.1 13.0 0.8 3.4 3 0 0 3 3 3 0 Zinc-finger double domain zf-C2H2_4 PF13894.6 ETO34033.1 - 0.13 13.2 16.0 0.36 11.8 4.8 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO34033.1 - 0.53 10.9 14.7 0.15 12.6 1.1 2.7 2 0 0 2 2 2 0 Zinc finger, C2H2 type DUF3361 PF11841.8 ETO34034.1 - 1.8 8.5 7.8 3.1 7.7 4.2 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF3361) zf-LYAR PF08790.11 ETO34035.1 - 0.084 12.8 0.6 0.084 12.8 0.6 2.1 2 0 0 2 2 2 0 LYAR-type C2HC zinc finger Kelch_2 PF07646.15 ETO34037.1 - 0.0015 18.4 8.3 7.3 6.7 0.1 5.0 3 1 1 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO34037.1 - 0.0058 16.9 6.0 0.6 10.5 0.0 4.3 4 1 1 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO34037.1 - 0.0084 16.1 1.2 6.7 6.8 0.1 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain PGBA_N PF15436.6 ETO34037.1 - 0.013 15.2 0.2 0.023 14.3 0.2 1.4 1 0 0 1 1 1 0 Plasminogen-binding protein pgbA N-terminal DKNYY PF13644.6 ETO34037.1 - 0.038 14.8 2.5 0.086 13.6 2.5 1.6 1 1 0 1 1 1 0 DKNYY family Kelch_5 PF13854.6 ETO34037.1 - 0.14 12.2 9.6 1.1 9.4 0.0 4.2 4 1 1 5 5 5 0 Kelch motif Kelch_1 PF01344.25 ETO34037.1 - 0.14 11.7 3.2 12 5.6 0.1 4.2 4 1 0 4 4 4 0 Kelch motif SOG2 PF10428.9 ETO34041.1 - 7 5.7 18.0 42 3.2 18.8 1.7 2 0 0 2 2 2 0 RAM signalling pathway protein NAD_binding_10 PF13460.6 ETO34043.1 - 1.2e-07 31.8 0.0 1.7e-07 31.3 0.0 1.2 1 0 0 1 1 1 1 NAD(P)H-binding Epimerase PF01370.21 ETO34043.1 - 5.6e-07 29.3 0.0 9.9e-07 28.5 0.0 1.5 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family adh_short PF00106.25 ETO34043.1 - 0.00036 20.0 0.0 0.00053 19.5 0.0 1.2 1 0 0 1 1 1 1 short chain dehydrogenase 3Beta_HSD PF01073.19 ETO34043.1 - 0.00044 19.4 0.0 0.00056 19.0 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family RmlD_sub_bind PF04321.17 ETO34043.1 - 0.0015 17.7 0.0 0.0022 17.1 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain GDP_Man_Dehyd PF16363.5 ETO34043.1 - 0.0069 15.8 0.0 0.012 15.1 0.0 1.3 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NmrA PF05368.13 ETO34043.1 - 0.0098 15.5 0.0 0.023 14.2 0.0 1.7 1 1 0 1 1 1 1 NmrA-like family 3HCDH_N PF02737.18 ETO34043.1 - 0.027 14.3 0.0 0.041 13.8 0.0 1.2 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain KR PF08659.10 ETO34043.1 - 0.042 13.8 0.0 0.071 13.0 0.0 1.3 1 0 0 1 1 1 0 KR domain DUF2937 PF11157.8 ETO34044.1 - 0.082 12.6 0.6 0.16 11.7 0.6 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2937) BEX PF04538.12 ETO34044.1 - 0.21 12.2 4.2 5.1 7.7 0.4 2.3 2 0 0 2 2 2 0 Brain expressed X-linked like family SAC3_GANP PF03399.16 ETO34044.1 - 1.5 8.1 7.0 4.1 6.7 3.3 2.5 2 1 0 2 2 2 0 SAC3/GANP family Aldedh PF00171.22 ETO34045.1 - 6e-68 229.4 0.3 7.3e-68 229.1 0.3 1.0 1 0 0 1 1 1 1 Aldehyde dehydrogenase family DUF4149 PF13664.6 ETO34046.1 - 0.39 11.1 0.1 0.39 11.1 0.1 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4149) RmlD_sub_bind PF04321.17 ETO34047.1 - 5.5e-14 51.9 0.0 1.8e-12 47.0 0.0 2.1 2 0 0 2 2 2 2 RmlD substrate binding domain Epimerase PF01370.21 ETO34047.1 - 1.3e-05 24.8 0.0 2e-05 24.2 0.0 1.3 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETO34047.1 - 0.13 11.5 0.0 0.51 9.5 0.0 1.7 1 1 1 2 2 2 0 Male sterility protein Epimerase PF01370.21 ETO34048.1 - 0.00023 20.7 0.1 0.0012 18.4 0.0 1.9 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family NAD_binding_4 PF07993.12 ETO34048.1 - 0.03 13.5 0.0 0.057 12.6 0.0 1.4 1 0 0 1 1 1 0 Male sterility protein GDP_Man_Dehyd PF16363.5 ETO34048.1 - 0.04 13.3 1.3 0.073 12.5 0.3 1.8 1 1 1 2 2 2 0 GDP-mannose 4,6 dehydratase Semialdhyde_dh PF01118.24 ETO34048.1 - 0.094 13.2 0.0 0.24 11.8 0.0 1.7 2 0 0 2 2 2 0 Semialdehyde dehydrogenase, NAD binding domain G-alpha PF00503.20 ETO34049.1 - 2.3e-16 59.9 2.1 2.8e-16 59.7 2.1 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Rad17 PF03215.15 ETO34049.1 - 0.001 19.0 0.8 0.0012 18.7 0.8 1.0 1 0 0 1 1 1 1 Rad17 P-loop domain MMR_HSR1 PF01926.23 ETO34049.1 - 0.012 15.7 0.1 0.021 14.9 0.1 1.8 1 1 0 1 1 1 0 50S ribosome-binding GTPase Arf PF00025.21 ETO34049.1 - 0.012 15.0 0.0 0.025 14.0 0.0 1.5 1 0 0 1 1 1 0 ADP-ribosylation factor family Roc PF08477.13 ETO34049.1 - 0.023 14.9 0.4 0.04 14.1 0.0 1.7 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase FeoB_N PF02421.18 ETO34049.1 - 0.028 14.0 0.2 0.39 10.2 0.0 2.2 2 0 0 2 2 2 0 Ferrous iron transport protein B AAA_24 PF13479.6 ETO34049.1 - 0.05 13.3 0.0 0.064 13.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO34049.1 - 0.071 12.5 0.0 0.11 11.8 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family MMPL PF03176.15 ETO34051.1 - 1.2e-56 192.1 7.3 2.7e-28 98.9 0.0 2.4 2 1 0 2 2 2 2 MMPL family ACR_tran PF00873.19 ETO34051.1 - 1.1 6.9 12.2 0.063 10.9 2.8 2.5 3 0 0 3 3 3 0 AcrB/AcrD/AcrF family RseC_MucC PF04246.12 ETO34051.1 - 1.6 8.7 11.3 0.13 12.3 1.9 3.1 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC TolA_bind_tri PF16331.5 ETO34053.1 - 1.1 9.4 7.4 2.9 8.0 0.9 2.4 1 1 1 2 2 2 0 TolA binding protein trimerisation Csm1_N PF18504.1 ETO34053.1 - 6.2 7.2 10.4 12 6.3 1.5 3.4 2 1 1 3 3 3 0 Csm1 N-terminal domain DUF4834 PF16118.5 ETO34055.1 - 0.019 15.9 1.5 0.019 15.9 1.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) TFIIA PF03153.13 ETO34055.1 - 4.6 7.1 14.5 5.7 6.8 14.5 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Presenilin PF01080.17 ETO34057.1 - 8.3 5.1 12.3 11 4.7 12.3 1.2 1 0 0 1 1 1 0 Presenilin RGS PF00615.19 ETO34058.1 - 5.5e-08 33.1 2.7 7.7e-08 32.6 2.7 1.1 1 0 0 1 1 1 1 Regulator of G protein signaling domain Lipase_GDSL_3 PF14606.6 ETO34058.1 - 0.13 12.4 0.3 0.18 11.9 0.3 1.2 1 0 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase family FAM193_C PF15914.5 ETO34060.1 - 0.039 13.7 1.1 0.76 9.6 0.4 2.5 2 0 0 2 2 2 0 FAM193 family C-terminal Tubulin PF00091.25 ETO34061.1 - 2.4e-59 200.8 0.1 3.3e-59 200.4 0.1 1.2 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO34061.1 - 1.3e-32 112.6 0.0 2.3e-32 111.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO34061.1 - 0.021 14.0 0.0 0.037 13.2 0.0 1.3 1 0 0 1 1 1 0 Tubulin like TPR_12 PF13424.6 ETO34063.1 - 5.1e-139 452.9 26.0 2.3e-19 69.5 0.5 9.9 6 2 3 10 10 10 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34063.1 - 2.1e-112 362.8 115.8 1.7e-10 40.3 2.0 16.2 16 0 0 16 16 16 14 Tetratricopeptide repeat TPR_10 PF13374.6 ETO34063.1 - 1.8e-103 336.0 16.3 8.3e-10 38.2 0.0 16.0 16 0 0 16 16 16 14 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34063.1 - 7.1e-94 300.6 80.0 2.7e-08 33.3 0.3 16.2 16 0 0 16 16 16 13 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34063.1 - 8.7e-93 296.9 112.0 1.4e-07 31.1 3.1 16.0 16 0 0 16 16 16 15 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34063.1 - 1.6e-89 287.6 36.6 1.6e-08 34.0 0.2 15.8 16 0 0 16 16 16 14 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34063.1 - 3.9e-40 133.4 44.8 0.0059 16.9 0.1 16.4 15 2 0 15 15 15 11 Tetratricopeptide repeat TPR_16 PF13432.6 ETO34063.1 - 4.8e-35 119.9 0.0 0.00059 20.4 0.0 12.5 7 4 5 13 13 13 8 Tetratricopeptide repeat TPR_6 PF13174.6 ETO34063.1 - 4.5e-33 111.7 23.4 0.042 14.5 0.1 14.7 16 0 0 16 16 14 7 Tetratricopeptide repeat TPR_14 PF13428.6 ETO34063.1 - 1.5e-30 103.2 0.0 0.12 13.2 0.0 13.9 13 2 2 15 15 14 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO34063.1 - 2.8e-26 90.9 131.7 6.7e-05 22.5 1.8 21.8 13 10 11 24 24 24 11 TPR repeat TPR_MalT PF17874.1 ETO34063.1 - 1.4e-18 67.4 0.0 0.0044 16.5 0.0 5.1 2 2 3 5 5 5 5 MalT-like TPR region TPR_3 PF07720.12 ETO34063.1 - 7.7e-14 51.3 69.2 0.06 13.4 0.3 14.1 14 0 0 14 14 14 6 Tetratricopeptide repeat DUF4810 PF16068.5 ETO34063.1 - 1.2e-13 51.4 27.4 1.3 9.6 0.0 12.0 10 2 1 12 12 11 2 Domain of unknown function (DUF4810) MIT PF04212.18 ETO34063.1 - 3.1e-13 49.6 70.5 0.15 12.2 0.5 14.3 14 1 1 15 15 15 8 MIT (microtubule interacting and transport) domain DUF5113 PF17140.4 ETO34063.1 - 1.9e-12 47.3 59.7 0.032 14.0 0.1 13.4 12 2 2 14 14 14 6 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO34063.1 - 5e-12 46.1 12.8 0.1 13.1 0.1 8.4 6 2 5 11 11 9 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO34063.1 - 5.1e-11 41.8 18.7 2.6 7.6 0.0 11.7 14 0 0 14 14 14 3 SHNi-TPR RPN7 PF10602.9 ETO34063.1 - 9.9e-11 41.6 37.2 0.0022 17.7 0.5 8.7 1 1 8 9 9 9 5 26S proteasome subunit RPN7 TPR_9 PF13371.6 ETO34063.1 - 4.3e-10 39.6 0.0 0.0015 18.6 0.0 6.3 6 2 1 7 7 7 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO34063.1 - 5.5e-09 36.1 45.9 0.011 16.0 2.2 9.2 2 2 9 12 12 12 7 Anaphase-promoting complex, cyclosome, subunit 3 PPR PF01535.20 ETO34063.1 - 2.6e-08 33.6 47.9 0.17 12.2 0.3 12.5 15 0 0 15 15 12 4 PPR repeat Sel1 PF08238.12 ETO34063.1 - 5.9e-06 26.8 40.5 1.7 9.4 0.1 14.0 14 2 0 14 14 14 1 Sel1 repeat KH_4 PF13083.6 ETO34063.1 - 0.00077 19.3 0.2 12 5.9 0.0 5.6 3 3 3 6 6 6 0 KH domain TPR_21 PF09976.9 ETO34063.1 - 0.023 14.4 9.0 26 4.5 0.0 6.3 4 2 2 6 6 6 0 Tetratricopeptide repeat-like domain Mob_Pre PF01076.19 ETO34063.1 - 0.049 13.4 34.7 0.12 12.2 1.4 7.0 1 1 8 9 9 9 0 Plasmid recombination enzyme Fis1_TPR_C PF14853.6 ETO34063.1 - 0.099 12.7 60.5 1.9 8.6 0.2 12.1 13 0 0 13 13 13 0 Fis1 C-terminal tetratricopeptide repeat Pep3_Vps18 PF05131.14 ETO34063.1 - 0.13 12.1 11.8 22 4.8 0.0 7.1 8 0 0 8 8 8 0 Pep3/Vps18/deep orange family DUF627 PF04781.12 ETO34063.1 - 4 7.5 22.2 5.3 7.1 0.1 7.2 8 3 1 9 9 7 0 Protein of unknown function (DUF627) SPO22 PF08631.10 ETO34063.1 - 8.9 5.7 33.6 20 4.6 0.2 9.2 7 4 3 12 12 12 0 Meiosis protein SPO22/ZIP4 like Hydantoinase_B PF02538.14 ETO34064.1 - 1.8e-18 66.3 0.8 2e-18 66.1 0.2 1.3 2 0 0 2 2 2 1 Hydantoinase B/oxoprolinase Hydantoinase_B PF02538.14 ETO34065.1 - 1.2e-136 456.2 0.1 1.4e-136 455.9 0.1 1.0 1 0 0 1 1 1 1 Hydantoinase B/oxoprolinase DUF496 PF04363.12 ETO34065.1 - 0.11 12.6 1.0 0.31 11.1 1.0 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF496) WD40 PF00400.32 ETO34066.1 - 6.3e-05 23.7 1.1 6.3e-05 23.7 1.1 2.4 2 2 0 2 2 2 1 WD domain, G-beta repeat DUF4882 PF16223.5 ETO34066.1 - 0.051 12.8 0.1 0.058 12.6 0.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4882) DAGK_acc PF00609.19 ETO34067.1 - 7e-35 120.7 0.0 2e-34 119.3 0.0 1.8 1 0 0 1 1 1 1 Diacylglycerol kinase accessory domain DAGK_cat PF00781.24 ETO34067.1 - 3.1e-15 55.9 0.0 9.7e-15 54.3 0.0 1.8 1 0 0 1 1 1 1 Diacylglycerol kinase catalytic domain GET2 PF08690.10 ETO34068.1 - 1.8 8.2 8.2 1.9 8.1 8.2 1.0 1 0 0 1 1 1 0 GET complex subunit GET2 Pannexin_like PF12534.8 ETO34068.1 - 9 5.3 6.2 9.5 5.2 6.2 1.0 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 RRS1 PF04939.12 ETO34069.1 - 2e-30 105.8 3.5 2.3e-30 105.6 3.5 1.1 1 0 0 1 1 1 1 Ribosome biogenesis regulatory protein (RRS1) Tsg PF04668.12 ETO34074.1 - 0.037 14.7 0.5 0.062 14.0 0.5 1.3 1 0 0 1 1 1 0 Twisted gastrulation (Tsg) protein conserved region UCR_UQCRX_QCR9 PF05365.12 ETO34074.1 - 1 9.4 4.6 0.42 10.6 0.7 2.3 3 0 0 3 3 3 0 Ubiquinol-cytochrome C reductase, UQCRX/QCR9 like WBS_methylT PF12589.8 ETO34075.1 - 0.089 13.6 2.7 0.21 12.4 0.1 2.4 3 0 0 3 3 3 0 Methyltransferase involved in Williams-Beuren syndrome DNA_pol_A PF00476.20 ETO34076.1 - 3.5e-65 220.5 4.4 3.6e-63 213.9 4.4 2.8 1 1 0 1 1 1 1 DNA polymerase family A Get5_C PF18514.1 ETO34076.1 - 0.045 13.5 0.6 9.2 6.1 0.0 3.8 4 0 0 4 4 4 0 Get5 C-terminal domain LdpA_C PF12617.8 ETO34076.1 - 0.1 12.2 0.0 15 5.1 0.0 2.3 2 0 0 2 2 2 0 Iron-Sulfur binding protein C terminal Lipase_GDSL_2 PF13472.6 ETO34077.1 - 1.4e-06 28.9 0.0 2.3e-06 28.1 0.0 1.3 1 0 0 1 1 1 1 GDSL-like Lipase/Acylhydrolase family Phi-29_GP3 PF05435.11 ETO34077.1 - 0.011 15.2 0.2 0.02 14.4 0.2 1.4 1 0 0 1 1 1 0 Phi-29 DNA terminal protein GP3 Pox_mRNA-cap PF03341.13 ETO34077.1 - 0.032 13.5 0.9 0.049 12.9 0.1 1.6 2 0 0 2 2 2 0 Poxvirus mRNA capping enzyme, small subunit Lipase_GDSL PF00657.22 ETO34077.1 - 0.06 13.3 0.5 0.13 12.3 0.5 1.6 1 1 0 1 1 1 0 GDSL-like Lipase/Acylhydrolase Pkinase PF00069.25 ETO34078.1 - 6.2e-80 268.4 0.0 1e-79 267.6 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34078.1 - 3.5e-39 134.7 0.0 5.5e-39 134.0 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase APH PF01636.23 ETO34078.1 - 1.1e-05 25.5 0.1 0.00054 20.0 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kdo PF06293.14 ETO34078.1 - 4.8e-05 22.8 0.4 0.00015 21.2 0.2 1.7 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO34078.1 - 0.0034 16.2 11.7 0.059 12.1 11.8 2.6 1 1 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO34078.1 - 0.015 14.6 0.1 0.084 12.2 0.1 2.4 1 1 0 1 1 1 0 Kinase-like SUR7 PF06687.12 ETO34078.1 - 0.041 13.5 0.1 1.6 8.3 0.0 2.3 2 0 0 2 2 2 0 SUR7/PalI family Imm8 PF15586.6 ETO34078.1 - 0.096 12.7 0.3 0.2 11.7 0.3 1.5 1 0 0 1 1 1 0 Immunity protein 8 Mucin PF01456.17 ETO34078.1 - 0.14 12.2 8.9 0.25 11.3 8.9 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein MARVEL PF01284.23 ETO34078.1 - 0.28 11.2 2.8 1 9.3 0.9 2.5 3 0 0 3 3 3 0 Membrane-associating domain HSP70 PF00012.20 ETO34080.1 - 1.2e-32 112.9 0.1 3e-32 111.6 0.1 1.5 1 1 0 1 1 1 1 Hsp70 protein Actin PF00022.19 ETO34080.1 - 0.00049 18.8 0.0 0.00073 18.2 0.0 1.2 1 0 0 1 1 1 1 Actin BcrAD_BadFG PF01869.20 ETO34080.1 - 0.015 14.8 0.0 0.022 14.3 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family MreB_Mbl PF06723.13 ETO34080.1 - 0.061 12.1 0.1 0.11 11.2 0.1 1.4 1 1 0 1 1 1 0 MreB/Mbl protein AnmK PF03702.14 ETO34080.1 - 0.15 11.1 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Anhydro-N-acetylmuramic acid kinase zf-C2H2_assoc PF16606.5 ETO34082.1 - 0.065 13.5 3.7 0.18 12.1 0.4 2.7 2 0 0 2 2 2 0 Unstructured conserved, between two C2H2-type zinc-fingers FSA_C PF10479.9 ETO34082.1 - 2.2 6.3 4.9 3.4 5.7 4.9 1.2 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus Acyl-CoA_dh_1 PF00441.24 ETO34083.1 - 3.5e-12 46.8 1.0 4.1e-12 46.5 1.0 1.0 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain ALS_ss_C PF10369.9 ETO34083.1 - 0.069 13.4 0.0 11 6.3 0.0 2.2 1 1 1 2 2 2 0 Small subunit of acetolactate synthase Tubulin PF00091.25 ETO34084.1 - 3.4e-58 197.1 0.2 2.4e-57 194.3 0.0 2.2 2 1 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO34084.1 - 1.3e-29 102.9 0.1 2.3e-29 102.1 0.1 1.3 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO34084.1 - 0.021 14.0 0.0 0.033 13.4 0.0 1.3 1 0 0 1 1 1 0 Tubulin like KH_7 PF17214.3 ETO34084.1 - 0.058 13.4 0.1 3.3 7.8 0.0 2.6 2 0 0 2 2 2 0 KH domain Acyl-CoA_dh_1 PF00441.24 ETO34085.1 - 4.9e-11 43.1 0.0 7.6e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Acyl-CoA dehydrogenase, C-terminal domain SMC_N PF02463.19 ETO34086.1 - 1.5e-28 99.7 83.9 2.2e-22 79.6 0.1 3.0 2 1 0 2 2 2 2 RecF/RecN/SMC N terminal domain SMC_hinge PF06470.13 ETO34086.1 - 1.9e-27 95.9 0.4 6.7e-27 94.1 0.0 2.3 2 0 0 2 2 1 1 SMC proteins Flexible Hinge Domain AAA_21 PF13304.6 ETO34086.1 - 2.5e-12 47.2 6.4 2.9e-07 30.6 0.0 3.7 4 1 0 4 4 4 2 AAA domain, putative AbiEii toxin, Type IV TA system AAA_15 PF13175.6 ETO34086.1 - 1.8e-11 44.4 19.0 1.8e-11 44.4 19.0 5.0 2 2 2 4 4 2 1 AAA ATPase domain AAA_29 PF13555.6 ETO34086.1 - 1.6e-05 24.6 0.0 4.4e-05 23.1 0.0 1.8 1 0 0 1 1 1 1 P-loop containing region of AAA domain SbcCD_C PF13558.6 ETO34086.1 - 0.00021 21.4 0.0 0.00071 19.8 0.0 2.0 1 0 0 1 1 1 1 Putative exonuclease SbcCD, C subunit AAA_23 PF13476.6 ETO34086.1 - 0.00041 20.9 44.8 0.00041 20.9 44.8 8.6 2 2 3 5 5 2 1 AAA domain DASH_Spc34 PF08657.10 ETO34086.1 - 0.0044 16.8 6.0 0.0044 16.8 6.0 7.1 4 2 2 6 6 2 1 DASH complex subunit Spc34 ABC_tran PF00005.27 ETO34086.1 - 0.25 11.9 0.0 0.25 11.9 0.0 6.4 3 2 0 3 3 1 0 ABC transporter AAA_27 PF13514.6 ETO34086.1 - 0.28 10.7 0.0 0.28 10.7 0.0 7.5 6 2 1 8 8 7 0 AAA domain DEAD PF00270.29 ETO34086.1 - 0.49 10.1 7.3 1.2 8.9 0.1 4.2 3 1 0 3 3 3 0 DEAD/DEAH box helicase AAA_22 PF13401.6 ETO34086.1 - 0.59 10.4 7.5 13 6.1 0.0 4.9 5 0 0 5 5 5 0 AAA domain TAP42 PF04177.12 ETO34087.1 - 0.019 14.1 5.7 0.36 9.9 2.4 2.1 2 0 0 2 2 2 0 TAP42-like family Brix PF04427.18 ETO34087.1 - 2.7 8.1 9.1 3.7 7.6 9.1 1.3 1 0 0 1 1 1 0 Brix domain DUF5054 PF16477.5 ETO34088.1 - 1.7e-27 97.0 0.0 4e-27 95.7 0.0 1.5 1 1 0 1 1 1 1 Domain of unknown function (DUF5054) DUF5576 PF17739.1 ETO34089.1 - 0.093 12.8 0.1 0.24 11.5 0.0 1.7 2 0 0 2 2 2 0 Family of unknown function (DUF5576) BCDHK_Adom3 PF10436.9 ETO34089.1 - 0.19 11.6 1.9 1.3 8.9 1.4 2.0 1 1 0 2 2 2 0 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase Tubulin_C PF03953.17 ETO34090.1 - 4.8e-12 46.2 0.1 1.3e-07 31.8 0.0 2.2 1 1 1 2 2 2 2 Tubulin C-terminal domain Lactonase PF10282.9 ETO34091.1 - 5.7e-11 42.3 0.0 6.4e-11 42.1 0.0 1.0 1 0 0 1 1 1 1 Lactonase, 7-bladed beta-propeller DUF1295 PF06966.12 ETO34092.1 - 3.7e-31 108.5 9.8 3.7e-31 108.5 9.8 2.0 2 0 0 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ETO34092.1 - 0.00021 21.7 0.6 0.0011 19.3 0.1 2.5 2 0 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO34092.1 - 0.023 15.1 1.0 0.023 15.1 1.0 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase CDT1_C PF16679.5 ETO34094.1 - 4.2e-06 27.1 3.8 4.2e-06 27.1 3.8 2.4 2 1 0 2 2 2 1 DNA replication factor Cdt1 C-terminal domain PmrD PF11183.8 ETO34094.1 - 0.0068 16.5 0.6 0.018 15.1 0.6 1.7 1 0 0 1 1 1 1 Polymyxin resistance protein PmrD R3H-assoc PF13902.6 ETO34094.1 - 0.054 13.9 0.1 0.13 12.7 0.1 1.7 1 0 0 1 1 1 0 R3H-associated N-terminal domain RNA_pol_Rpb8 PF03870.15 ETO34095.1 - 7.3e-46 155.8 0.5 8.8e-46 155.6 0.5 1.1 1 0 0 1 1 1 1 RNA polymerase Rpb8 RNA_pol_RpbG PF16992.5 ETO34095.1 - 0.0019 18.2 1.3 0.025 14.6 0.1 2.2 1 1 0 2 2 2 1 DNA-directed RNA polymerase, subunit G TOBE PF03459.17 ETO34095.1 - 0.092 13.1 0.0 0.18 12.1 0.0 1.5 1 0 0 1 1 1 0 TOBE domain Amidase PF01425.21 ETO34096.1 - 1.7e-34 119.6 0.0 6e-23 81.5 0.0 2.0 2 0 0 2 2 2 2 Amidase Kelch_4 PF13418.6 ETO34097.1 - 0.0047 16.9 0.2 0.73 9.9 0.1 3.1 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO34097.1 - 0.043 13.8 2.2 9 6.5 0.2 3.8 4 0 0 4 4 4 0 Kelch motif zf-C2H2 PF00096.26 ETO34098.1 - 5.7e-11 42.2 26.8 9.8e-05 22.6 1.5 3.6 3 0 0 3 3 3 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO34098.1 - 8.5e-08 32.4 27.1 0.0036 18.0 1.0 3.8 4 0 0 4 4 3 3 C2H2-type zinc finger zf-met PF12874.7 ETO34098.1 - 7.6e-07 29.3 17.5 0.018 15.5 1.2 3.5 3 0 0 3 3 3 3 Zinc-finger of C2H2 type zf-H2C2_2 PF13465.6 ETO34098.1 - 2.1e-05 24.7 25.9 0.01 16.2 4.5 4.6 4 0 0 4 4 4 3 Zinc-finger double domain zf-C2H2_11 PF16622.5 ETO34098.1 - 0.0014 18.3 2.4 0.0014 18.3 2.4 3.3 3 0 0 3 3 3 1 zinc-finger C2H2-type zf-C2H2_jaz PF12171.8 ETO34098.1 - 0.11 12.8 0.8 0.11 12.8 0.8 3.6 3 0 0 3 3 3 0 Zinc-finger double-stranded RNA-binding zf-C2H2_3rep PF18868.1 ETO34098.1 - 0.13 13.0 12.5 5 7.8 1.0 3.0 1 1 2 3 3 3 0 Zinc finger C2H2-type, 3 repeats zf-C2H2_8 PF15909.5 ETO34098.1 - 0.27 11.6 14.7 2.8 8.3 3.9 2.4 1 1 1 2 2 2 0 C2H2-type zinc ribbon zinc_ribbon_5 PF13719.6 ETO34098.1 - 0.41 10.4 8.8 3.1 7.6 0.8 2.7 2 0 0 2 2 2 0 zinc-ribbon domain zf_C2H2_ZHX PF18387.1 ETO34098.1 - 0.57 9.9 0.1 0.57 9.9 0.1 3.2 1 1 2 3 3 3 0 Zinc-fingers and homeoboxes C2H2 finger domain zf-C2H2_2 PF12756.7 ETO34098.1 - 1.3 9.4 25.7 0.45 10.9 2.2 3.6 2 1 2 4 4 4 0 C2H2 type zinc-finger (2 copies) Zn_Tnp_IS1595 PF12760.7 ETO34098.1 - 2.1 8.4 10.9 13 5.8 0.4 2.8 2 1 0 2 2 2 0 Transposase zinc-ribbon domain zf_UBZ PF18439.1 ETO34098.1 - 2.4 7.8 12.3 3.7 7.2 1.5 3.6 3 0 0 3 3 3 0 Ubiquitin-Binding Zinc Finger zf-LYAR PF08790.11 ETO34098.1 - 7.4 6.6 16.1 1.7 8.6 1.3 3.4 3 0 0 3 3 3 0 LYAR-type C2HC zinc finger zf-MYST PF17772.1 ETO34098.1 - 9.7 5.9 15.6 2.6 7.7 2.2 3.5 2 1 1 3 3 3 0 MYST family zinc finger domain G0-G1_switch_2 PF15103.6 ETO34099.1 - 0.0084 16.5 0.9 0.017 15.5 0.3 1.7 2 0 0 2 2 2 1 G0/G1 switch protein 2 Med12-LCEWAV PF12145.8 ETO34099.1 - 0.38 9.6 6.5 0.079 11.8 3.2 1.4 2 0 0 2 2 2 0 Eukaryotic Mediator 12 subunit domain ABC_tran_CTD PF16326.5 ETO34100.1 - 0.0074 16.5 11.3 0.076 13.3 4.6 2.8 2 1 0 2 2 2 2 ABC transporter C-terminal domain FapA PF03961.13 ETO34100.1 - 0.19 10.3 5.4 0.15 10.6 4.3 1.3 1 1 0 1 1 1 0 Flagellar Assembly Protein A LMBR1 PF04791.16 ETO34100.1 - 0.2 10.5 2.4 0.23 10.3 2.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Exonuc_VII_L PF02601.15 ETO34100.1 - 0.22 11.1 5.0 0.27 10.8 5.0 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF4407 PF14362.6 ETO34100.1 - 0.45 9.8 2.6 0.79 9.0 2.3 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spore_III_AB PF09548.10 ETO34100.1 - 0.9 9.6 9.5 4 7.5 2.1 2.1 2 0 0 2 2 2 0 Stage III sporulation protein AB (spore_III_AB) Macro PF01661.21 ETO34101.1 - 2.8e-28 98.3 0.3 4.6e-28 97.6 0.3 1.4 1 0 0 1 1 1 1 Macro domain 7TM_GPCR_Srd PF10317.9 ETO34102.1 - 0.031 13.5 0.9 0.06 12.5 0.9 1.4 1 0 0 1 1 1 0 Serpentine type 7TM GPCR chemoreceptor Srd PTR2 PF00854.21 ETO34102.1 - 0.07 11.9 0.4 0.12 11.2 0.4 1.3 1 0 0 1 1 1 0 POT family O-ag_pol_Wzy PF14296.6 ETO34102.1 - 0.41 9.2 3.3 7.1 5.2 0.1 2.2 2 0 0 2 2 2 0 O-antigen polysaccharide polymerase Wzy Arrestin_C PF02752.22 ETO34102.1 - 0.42 11.1 4.2 0.22 12.0 1.7 1.8 2 0 0 2 2 2 0 Arrestin (or S-antigen), C-terminal domain DUF4264 PF14084.6 ETO34103.1 - 0.17 11.5 4.0 0.16 11.6 1.0 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF4264) ERM PF00769.19 ETO34104.1 - 0.0011 18.8 22.2 0.0028 17.5 22.2 1.6 1 0 0 1 1 1 1 Ezrin/radixin/moesin family Macoilin PF09726.9 ETO34104.1 - 0.0037 15.9 28.3 0.0042 15.7 28.3 1.0 1 0 0 1 1 1 1 Macoilin family BRE1 PF08647.11 ETO34104.1 - 0.0057 16.7 13.8 0.0057 16.7 13.8 3.5 1 1 3 4 4 4 1 BRE1 E3 ubiquitin ligase ATG16 PF08614.11 ETO34104.1 - 0.033 14.4 26.2 0.13 12.5 25.9 2.1 1 1 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF1664 PF07889.12 ETO34104.1 - 0.15 12.1 20.7 0.19 11.7 9.4 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) TMF_TATA_bd PF12325.8 ETO34104.1 - 0.3 11.3 28.9 0.34 11.2 11.7 2.9 2 1 1 3 3 3 0 TATA element modulatory factor 1 TATA binding Phage_GP20 PF06810.11 ETO34104.1 - 0.68 9.7 36.6 0.15 11.9 20.2 3.3 1 1 1 2 2 2 0 Phage minor structural protein GP20 DegS PF05384.11 ETO34104.1 - 2.2 7.7 28.7 4.9 6.6 20.6 2.5 1 1 1 2 2 2 0 Sensor protein DegS Fez1 PF06818.15 ETO34104.1 - 3 8.2 34.6 0.98 9.8 28.1 2.6 1 1 2 3 3 3 0 Fez1 HIP1_clath_bdg PF16515.5 ETO34104.1 - 6.5 7.4 33.0 0.071 13.7 7.2 3.6 1 1 2 3 3 3 0 Clathrin-binding domain of Huntingtin-interacting protein 1 CENP-H PF05837.12 ETO34104.1 - 8.6 6.8 31.1 0.43 11.0 10.5 3.3 1 1 2 3 3 3 0 Centromere protein H (CENP-H) DUF2961 PF11175.8 ETO34105.1 - 7.1e-20 71.7 0.1 1.7e-19 70.4 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF2961) TPR_2 PF07719.17 ETO34106.1 - 0.00024 20.9 0.9 0.041 14.0 1.0 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34106.1 - 0.0029 17.9 0.8 0.24 11.9 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO34106.1 - 0.014 15.7 0.1 0.033 14.5 0.1 1.6 1 1 0 1 1 1 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO34106.1 - 0.016 15.7 0.1 0.085 13.4 0.0 2.0 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34106.1 - 0.02 15.1 0.2 3.8 8.0 0.0 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34106.1 - 0.026 14.3 0.2 0.092 12.6 0.6 1.8 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_C2 PF00648.21 ETO34107.1 - 5.1e-31 107.8 0.0 9.9e-31 106.9 0.0 1.4 1 1 0 1 1 1 1 Calpain family cysteine protease PsbI PF02532.14 ETO34107.1 - 0.5 10.3 8.2 0.2 11.6 5.4 1.8 2 0 0 2 2 2 0 Photosystem II reaction centre I protein (PSII 4.8 kDa protein) EMP24_GP25L PF01105.24 ETO34108.1 - 2.1e-15 57.2 6.4 2.1e-15 57.2 6.4 1.7 1 1 1 2 2 2 1 emp24/gp25L/p24 family/GOLD FYVE PF01363.21 ETO34109.1 - 3.8 7.7 6.5 25 5.1 2.2 2.8 2 1 0 2 2 2 0 FYVE zinc finger DUF3825 PF12873.7 ETO34110.1 - 0.00099 18.6 2.0 1.3 8.4 0.0 3.5 4 0 0 4 4 4 2 Domain of unknown function (DUF3825) UvsY PF11056.8 ETO34110.1 - 0.1 12.9 0.7 1.6 9.1 0.2 2.7 2 0 0 2 2 2 0 Recombination, repair and ssDNA binding protein UvsY Sulfatase PF00884.23 ETO34111.1 - 4e-18 65.9 0.0 2.9e-17 63.0 0.0 1.9 2 0 0 2 2 2 1 Sulfatase Sulfatase_C PF14707.6 ETO34111.1 - 6.5e-16 59.2 7.3 3.4e-15 56.9 7.3 2.2 2 1 0 2 2 2 1 C-terminal region of aryl-sulfatase Phosphodiest PF01663.22 ETO34111.1 - 1.7e-05 24.6 0.0 3.5e-05 23.6 0.0 1.4 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase DUF1501 PF07394.12 ETO34111.1 - 0.041 12.9 0.0 0.062 12.4 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) DSPc PF00782.20 ETO34112.1 - 1.1e-24 86.7 0.4 1.5e-24 86.3 0.4 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain zf-Di19 PF05605.12 ETO34112.1 - 1.3e-05 25.4 1.0 3.2e-05 24.1 1.0 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding Y_phosphatase PF00102.27 ETO34112.1 - 0.0027 17.3 0.0 0.003 17.2 0.0 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase Init_tRNA_PT PF04179.12 ETO34112.1 - 0.0077 16.5 0.0 0.012 15.9 0.0 1.4 1 0 0 1 1 1 1 Rit1 DUSP-like domain Y_phosphatase2 PF03162.13 ETO34112.1 - 0.0084 15.7 0.5 0.02 14.5 0.3 1.7 1 1 1 2 2 2 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ETO34112.1 - 0.019 14.9 0.0 0.027 14.5 0.0 1.2 1 0 0 1 1 1 0 Tyrosine phosphatase family CDKN3 PF05706.12 ETO34112.1 - 0.021 14.5 0.0 0.03 14.0 0.0 1.2 1 0 0 1 1 1 0 Cyclin-dependent kinase inhibitor 3 (CDKN3) zf-C2H2_4 PF13894.6 ETO34112.1 - 2 9.5 6.0 0.33 11.9 1.1 2.3 2 0 0 2 2 2 0 C2H2-type zinc finger CXCXC PF03128.14 ETO34113.1 - 0.024 15.0 0.5 0.071 13.6 0.5 1.8 1 0 0 1 1 1 0 CXCXC repeat PH_10 PF15411.6 ETO34113.1 - 0.045 14.0 0.1 0.089 13.1 0.1 1.5 1 0 0 1 1 1 0 Pleckstrin homology domain PPR PF01535.20 ETO34116.1 - 3.2e-14 52.1 9.0 0.00046 20.2 0.2 4.9 5 0 0 5 5 5 4 PPR repeat PPR_2 PF13041.6 ETO34116.1 - 1e-08 35.2 15.6 0.0043 17.2 0.1 5.3 5 1 1 6 6 6 3 PPR repeat family PPR_1 PF12854.7 ETO34116.1 - 3.2e-08 33.1 4.7 0.028 14.1 0.0 3.5 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.6 ETO34116.1 - 2.9e-06 27.3 8.8 0.0059 16.6 0.1 5.0 3 1 2 5 5 5 3 Pentatricopeptide repeat domain ATP13 PF12921.7 ETO34116.1 - 0.0069 16.2 0.3 0.0069 16.2 0.3 2.9 3 1 1 4 4 4 1 Mitochondrial ATPase expression Peptidase_S9_N PF02897.15 ETO34117.1 - 2.4e-13 49.7 0.0 3.6e-07 29.3 0.0 2.0 2 0 0 2 2 2 2 Prolyl oligopeptidase, N-terminal beta-propeller domain WD40 PF00400.32 ETO34119.1 - 0.0013 19.5 0.4 0.0013 19.5 0.4 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO34120.1 - 8e-07 29.7 7.2 6.4e-06 26.8 2.9 3.1 3 0 0 3 3 3 1 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO34120.1 - 0.00018 22.1 7.1 0.00018 22.1 7.1 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger PUB PF09409.10 ETO34121.1 - 0.02 14.8 6.4 0.02 14.8 6.4 2.9 3 1 0 3 3 3 0 PUB domain Histidinol_dh PF00815.20 ETO34123.1 - 0.011 14.8 1.5 0.019 14.0 1.5 1.3 1 0 0 1 1 1 0 Histidinol dehydrogenase DIT1_PvcA PF05141.12 ETO34123.1 - 0.013 15.0 2.3 0.023 14.2 2.3 1.4 1 0 0 1 1 1 0 Pyoverdine/dityrosine biosynthesis protein DUF3583 PF12126.8 ETO34123.1 - 0.016 14.7 3.2 0.027 14.0 3.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3583) SprA-related PF12118.8 ETO34123.1 - 0.026 13.7 6.5 0.041 13.0 6.5 1.2 1 0 0 1 1 1 0 SprA-related family HalX PF08663.10 ETO34123.1 - 0.028 14.7 0.6 0.028 14.7 0.6 1.7 2 0 0 2 2 2 0 HalX domain DUF1908 PF08926.11 ETO34123.1 - 1.7 7.7 8.5 0.32 10.0 4.3 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF1908) N_BRCA1_IG PF16158.5 ETO34124.1 - 7.4e-12 45.9 0.0 1.7e-11 44.7 0.0 1.6 1 0 0 1 1 1 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 ETO34124.1 - 4e-11 42.5 3.7 1e-10 41.2 3.7 1.8 1 0 0 1 1 1 1 Zinc finger, ZZ type Syntaxin-18_N PF10496.9 ETO34125.1 - 0.38 11.0 0.1 0.38 11.0 0.1 3.0 2 1 1 3 3 3 0 SNARE-complex protein Syntaxin-18 N-terminus DUF1779 PF08680.10 ETO34125.1 - 1.6 8.9 5.3 0.38 10.9 0.4 2.0 2 0 0 2 2 2 0 TATA-box binding RhoGAP PF00620.27 ETO34126.1 - 2.3e-18 66.5 0.5 5.5e-18 65.2 0.5 1.7 1 0 0 1 1 1 1 RhoGAP domain Pterin_4a PF01329.19 ETO34127.1 - 0.12 12.5 0.1 0.43 10.8 0.1 1.9 1 0 0 1 1 1 0 Pterin 4 alpha carbinolamine dehydratase XRN1_D1 PF18332.1 ETO34127.1 - 0.13 12.0 0.5 4.1 7.1 0.0 2.3 2 0 0 2 2 2 0 Exoribonuclease Xrn1 D1 domain Arf PF00025.21 ETO34128.1 - 2.9e-24 85.5 0.7 4.5e-12 45.8 0.1 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family G-alpha PF00503.20 ETO34128.1 - 0.056 12.6 0.0 0.075 12.2 0.0 1.4 1 1 0 1 1 1 0 G-protein alpha subunit RPN2_C PF18004.1 ETO34130.1 - 0.17 11.8 17.1 0.17 11.8 17.1 1.0 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain Ctr PF04145.15 ETO34130.1 - 0.27 11.8 1.4 0.28 11.8 1.4 1.0 1 0 0 1 1 1 0 Ctr copper transporter family DUF4834 PF16118.5 ETO34130.1 - 2.9 8.9 11.0 3.7 8.6 11.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) MCM_bind PF09739.9 ETO34130.1 - 5.7 5.3 15.1 5.7 5.3 15.1 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Neisseria_TspB PF05616.13 ETO34131.1 - 0.026 13.0 11.2 0.036 12.6 11.2 1.2 1 0 0 1 1 1 0 Neisseria meningitidis TspB protein PSI_PsaH PF03244.14 ETO34131.1 - 0.081 12.4 0.2 0.22 11.0 0.2 1.7 1 0 0 1 1 1 0 Photosystem I reaction centre subunit VI Kinesin PF00225.23 ETO34132.1 - 3.1e-92 309.1 0.2 3.1e-92 309.1 0.2 2.7 2 2 1 3 3 3 1 Kinesin motor domain Microtub_bd PF16796.5 ETO34132.1 - 1.2e-52 177.8 0.5 1.2e-52 177.8 0.5 2.3 2 1 0 2 2 2 1 Microtubule binding Trimer_CC PF08954.11 ETO34132.1 - 0.38 10.4 7.0 0.35 10.5 1.2 2.8 2 0 0 2 2 2 0 Trimerisation motif AAA_22 PF13401.6 ETO34132.1 - 0.93 9.8 0.0 0.93 9.8 0.0 3.5 3 2 0 3 3 3 0 AAA domain EF-hand_2 PF09068.11 ETO34132.1 - 5.5 7.2 7.7 3.2 7.9 4.7 2.1 2 0 0 2 2 2 0 EF hand USP8_interact PF08941.10 ETO34132.1 - 5.9 6.7 19.5 0.21 11.4 6.5 2.7 2 0 0 2 2 2 0 USP8 interacting Herpes_UL92 PF03048.14 ETO34133.1 - 0.00021 21.2 4.3 0.00026 20.8 4.3 1.1 1 0 0 1 1 1 1 UL92 family ATPase_2 PF01637.18 ETO34133.1 - 0.00052 20.0 7.3 0.00075 19.5 7.3 1.3 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea DUF5098 PF17023.5 ETO34133.1 - 0.00053 19.1 8.9 0.00067 18.7 8.9 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF5098) ATP-synt_B PF00430.18 ETO34133.1 - 0.0035 17.4 6.4 0.007 16.5 6.4 1.5 1 0 0 1 1 1 1 ATP synthase B/B' CF(0) Fib_alpha PF08702.10 ETO34133.1 - 0.0038 17.4 12.2 0.0058 16.8 12.2 1.3 1 0 0 1 1 1 1 Fibrinogen alpha/beta chain family FliT PF05400.13 ETO34133.1 - 0.0084 16.9 1.2 0.017 15.9 1.2 1.6 1 0 0 1 1 1 1 Flagellar protein FliT UPF0242 PF06785.11 ETO34133.1 - 0.012 15.7 12.5 0.019 15.1 12.5 1.3 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF2935 PF11155.8 ETO34133.1 - 0.014 15.7 4.8 0.024 15.0 4.8 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF2935) GBP_C PF02841.14 ETO34133.1 - 0.015 14.7 15.1 0.02 14.3 15.1 1.2 1 0 0 1 1 1 0 Guanylate-binding protein, C-terminal domain Seryl_tRNA_N PF02403.22 ETO34133.1 - 0.018 15.3 18.9 0.024 14.8 18.4 1.5 1 1 0 1 1 1 0 Seryl-tRNA synthetase N-terminal domain Atg14 PF10186.9 ETO34133.1 - 0.025 13.7 8.6 0.032 13.3 8.6 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 DUF812 PF05667.11 ETO34133.1 - 0.034 13.0 17.0 0.041 12.8 17.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF883 PF05957.13 ETO34133.1 - 0.059 14.0 3.5 0.13 12.8 3.2 1.7 1 1 0 1 1 1 0 Bacterial protein of unknown function (DUF883) LUC7 PF03194.15 ETO34133.1 - 0.063 12.9 8.4 0.083 12.5 8.4 1.2 1 0 0 1 1 1 0 LUC7 N_terminus CRIC_ras_sig PF10534.9 ETO34133.1 - 0.066 13.4 1.2 0.29 11.3 1.2 2.0 1 1 0 1 1 1 0 Connector enhancer of kinase suppressor of ras MMPL PF03176.15 ETO34133.1 - 0.076 11.9 0.7 0.13 11.2 0.7 1.3 1 0 0 1 1 1 0 MMPL family FmdE PF02663.14 ETO34133.1 - 0.11 12.5 5.1 0.19 11.8 5.1 1.4 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Tai4 PF16695.5 ETO34133.1 - 0.19 12.3 1.8 0.77 10.3 0.4 2.1 1 1 1 2 2 2 0 Type VI secretion system (T6SS), amidase immunity protein DUF5593 PF18007.1 ETO34133.1 - 0.28 11.9 1.9 0.64 10.7 0.9 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF5593) LCIB_C_CA PF18599.1 ETO34133.1 - 0.35 10.1 2.7 0.38 10.0 2.7 1.2 1 0 0 1 1 1 0 Limiting CO2-inducible proteins B/C beta carbonyic anhydrases PIN_12 PF16289.5 ETO34133.1 - 0.37 11.3 11.3 0.49 10.9 11.3 1.2 1 0 0 1 1 1 0 PIN domain Prominin PF05478.11 ETO34133.1 - 0.5 8.2 10.3 0.73 7.7 9.6 1.3 1 1 0 1 1 1 0 Prominin CAF1 PF04857.20 ETO34133.1 - 0.53 9.4 5.3 0.56 9.3 5.3 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Caldesmon PF02029.15 ETO34133.1 - 0.57 8.9 17.2 0.75 8.5 17.2 1.1 1 0 0 1 1 1 0 Caldesmon DUF1515 PF07439.11 ETO34133.1 - 0.73 9.9 5.5 0.91 9.6 4.8 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF1515) APG6_N PF17675.1 ETO34133.1 - 1.1 9.8 17.2 1.8 9.1 17.2 1.5 1 1 0 1 1 1 0 Apg6 coiled-coil region LMBR1 PF04791.16 ETO34133.1 - 1.2 8.0 5.4 1.2 7.9 5.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Gp-FAR-1 PF05823.12 ETO34133.1 - 1.2 9.4 15.6 2.8 8.3 15.6 1.6 1 1 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) HIP1_clath_bdg PF16515.5 ETO34133.1 - 1.3 9.7 14.9 0.76 10.4 12.8 1.7 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 DUF1002 PF06207.11 ETO34133.1 - 2.1 7.8 13.6 2.6 7.5 0.5 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) DUF2229 PF09989.9 ETO34133.1 - 2.9 7.5 8.0 3.7 7.1 7.8 1.4 1 1 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) Ax_dynein_light PF10211.9 ETO34133.1 - 4 7.3 17.2 5.2 7.0 16.6 1.5 1 1 0 1 1 1 0 Axonemal dynein light chain AAA_23 PF13476.6 ETO34133.1 - 6 7.3 16.9 8.7 6.8 16.9 1.2 1 0 0 1 1 1 0 AAA domain YtxH PF12732.7 ETO34133.1 - 9.7 6.8 12.0 26 5.5 12.0 2.0 1 1 0 1 1 1 0 YtxH-like protein Acetyltransf_1 PF00583.25 ETO34134.1 - 1.8e-05 25.0 0.2 4e-05 23.8 0.2 1.6 1 1 0 1 1 1 1 Acetyltransferase (GNAT) family Acetyltransf_9 PF13527.7 ETO34134.1 - 0.0027 17.8 0.0 0.23 11.5 0.0 2.2 2 0 0 2 2 2 1 Acetyltransferase (GNAT) domain Acetyltransf_7 PF13508.7 ETO34134.1 - 0.0055 17.1 0.0 0.011 16.1 0.0 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_10 PF13673.7 ETO34134.1 - 0.0058 16.6 0.0 0.011 15.7 0.0 1.4 1 0 0 1 1 1 1 Acetyltransferase (GNAT) domain Acetyltransf_15 PF17013.5 ETO34134.1 - 0.066 12.7 0.2 0.11 11.9 0.1 1.5 1 1 0 1 1 1 0 Putative acetyl-transferase BET PF17035.5 ETO34136.1 - 3.7e-13 49.4 0.7 8e-13 48.4 0.7 1.6 1 0 0 1 1 1 1 Bromodomain extra-terminal - transcription regulation Cut8 PF08559.10 ETO34136.1 - 0.065 12.8 0.5 0.096 12.3 0.2 1.4 1 1 0 1 1 1 0 Cut8, nuclear proteasome tether protein Folate_carrier PF01770.18 ETO34137.1 - 0.027 13.2 2.6 0.036 12.8 2.6 1.2 1 0 0 1 1 1 0 Reduced folate carrier EFTUD2 PF16004.5 ETO34137.1 - 0.068 13.8 2.6 0.11 13.1 2.6 1.3 1 0 0 1 1 1 0 116 kDa U5 small nuclear ribonucleoprotein component N-terminus Ribonuc_2-5A PF06479.12 ETO34137.1 - 0.43 10.8 5.8 0.42 10.8 4.2 1.7 2 0 0 2 2 2 0 Ribonuclease 2-5A Cyclin_N PF00134.23 ETO34138.1 - 6.4e-14 51.8 0.6 1.1e-13 51.0 0.6 1.4 1 1 0 1 1 1 1 Cyclin, N-terminal domain TFIIB PF00382.19 ETO34138.1 - 0.0041 17.1 0.0 0.0073 16.3 0.0 1.3 1 0 0 1 1 1 1 Transcription factor TFIIB repeat NOD PF06816.13 ETO34138.1 - 0.14 11.8 0.1 0.29 10.8 0.1 1.5 1 0 0 1 1 1 0 NOTCH protein Kinase-PolyVal PF18762.1 ETO34141.1 - 0.025 14.5 1.3 0.031 14.2 1.3 1.2 1 0 0 1 1 1 0 Serine/Threonine/Tyrosine Kinase found in polyvalent proteins UCH PF00443.29 ETO34143.1 - 8.1e-45 153.3 2.3 8.1e-45 153.3 2.3 1.8 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO34143.1 - 2.1e-08 34.2 12.7 2.1e-08 34.2 12.7 2.6 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase ubiquitin PF00240.23 ETO34143.1 - 9.1e-08 31.8 0.5 2.4e-07 30.4 0.5 1.8 1 0 0 1 1 1 1 Ubiquitin family TBK1_ULD PF18396.1 ETO34143.1 - 0.0013 18.7 0.0 0.0029 17.5 0.0 1.5 1 0 0 1 1 1 1 TANK binding kinase 1 ubiquitin-like domain CDC45 PF02724.14 ETO34143.1 - 0.056 11.7 8.1 0.099 10.9 8.1 1.5 1 0 0 1 1 1 0 CDC45-like protein CNDH2_C PF16858.5 ETO34143.1 - 0.43 10.4 19.9 0.055 13.3 10.4 2.4 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term PTPRCAP PF15713.5 ETO34143.1 - 6.5 7.0 11.7 24 5.2 11.7 1.9 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated Vhr1 PF04001.13 ETO34146.1 - 0.02 15.2 1.1 0.058 13.7 0.5 2.1 1 1 0 2 2 2 0 Transcription factor Vhr1 DUF2207 PF09972.9 ETO34146.1 - 5.5 5.6 8.9 18 3.9 8.9 1.8 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Macoilin PF09726.9 ETO34147.1 - 1.4 7.4 13.6 5.7 5.4 13.6 1.7 1 1 0 1 1 1 0 Macoilin family DivIC PF04977.15 ETO34147.1 - 6.4 6.6 9.5 8.6 6.2 2.7 2.6 2 0 0 2 2 2 0 Septum formation initiator DUF4201 PF13870.6 ETO34148.1 - 3.2e-19 69.3 31.1 3.2e-19 69.3 31.1 3.2 2 2 0 2 2 2 1 Domain of unknown function (DUF4201) DUF3417 PF11897.8 ETO34149.1 - 0.048 14.1 0.0 0.13 12.8 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3417) TFIIA PF03153.13 ETO34149.1 - 0.53 10.2 12.7 0.8 9.6 12.7 1.3 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Pox_Ag35 PF03286.14 ETO34151.1 - 0.056 13.2 0.1 0.071 12.9 0.1 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF3482 PF11981.8 ETO34152.1 - 0.01 15.3 0.4 0.01 15.2 0.4 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) Hexapep PF00132.24 ETO34153.1 - 0.0016 18.1 20.6 0.0073 16.0 2.4 4.4 5 0 0 5 5 5 2 Bacterial transferase hexapeptide (six repeats) Hexapep_2 PF14602.6 ETO34153.1 - 0.031 14.0 8.0 0.87 9.4 2.8 2.6 2 1 0 2 2 2 0 Hexapeptide repeat of succinyl-transferase Rib_recp_KP_reg PF05104.12 ETO34153.1 - 0.21 12.7 8.2 0.37 11.8 8.2 1.3 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region PHD PF00628.29 ETO34154.1 - 9.8e-09 35.0 10.4 1.9e-08 34.1 10.4 1.5 1 0 0 1 1 1 1 PHD-finger VSG_B PF13206.6 ETO34154.1 - 3.6e-05 23.2 5.7 5e-05 22.7 5.7 1.1 1 0 0 1 1 1 1 Trypanosomal VSG domain PHD_4 PF16866.5 ETO34154.1 - 0.43 10.7 7.0 1.2 9.2 7.0 1.8 1 0 0 1 1 1 0 PHD-finger DEP PF00610.21 ETO34155.1 - 9.1e-18 64.1 0.2 2e-17 63.0 0.2 1.6 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) WD40 PF00400.32 ETO34156.1 - 3.1e-32 110.1 26.2 2.6e-06 28.1 1.4 7.3 6 1 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO34156.1 - 1.3e-10 40.5 0.9 0.082 11.5 0.3 5.1 3 1 2 5 5 5 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34156.1 - 8.2e-10 38.9 3.2 0.098 13.0 0.0 6.3 5 1 2 7 7 7 2 Anaphase-promoting complex subunit 4 WD40 domain SH3_2 PF07653.17 ETO34156.1 - 0.12 12.0 0.2 0.78 9.5 0.1 2.3 2 0 0 2 2 2 0 Variant SH3 domain ZapB PF06005.12 ETO34156.1 - 6.8 7.2 21.6 8.5 6.9 7.3 2.6 1 1 1 2 2 2 0 Cell division protein ZapB DUF1189 PF06691.11 ETO34156.1 - 7.7 6.0 5.9 13 5.3 5.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1189) Phage_connect_1 PF05135.13 ETO34158.1 - 0.038 14.5 0.1 0.11 13.1 0.1 1.8 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein DHR10 PF18595.1 ETO34158.1 - 0.11 12.5 0.5 6.8 6.8 0.0 2.6 2 1 0 2 2 2 0 Designed helical repeat protein 10 domain DUF2312 PF10073.9 ETO34160.1 - 0.13 12.0 0.0 0.25 11.0 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2312) DUF1295 PF06966.12 ETO34162.1 - 7.1e-30 104.3 19.4 7.1e-30 104.3 19.4 1.7 1 1 1 2 2 2 1 Protein of unknown function (DUF1295) ICMT PF04140.14 ETO34162.1 - 0.001 19.4 3.0 0.0013 19.2 0.4 2.6 2 1 0 2 2 2 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO34162.1 - 0.021 15.2 1.8 0.021 15.2 1.8 2.2 2 0 0 2 2 2 0 Phospholipid methyltransferase V_ATPase_I PF01496.19 ETO34163.1 - 6.2e-249 828.2 11.2 7e-249 828.0 11.2 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family LRR19-TM PF15176.6 ETO34163.1 - 0.0029 17.6 0.0 0.016 15.2 0.1 2.3 2 0 0 2 2 2 1 Leucine-rich repeat family 19 TM domain Tmemb_9 PF05434.11 ETO34163.1 - 0.12 12.3 0.2 0.12 12.3 0.2 2.6 2 0 0 2 2 2 0 TMEM9 DUF4315 PF14193.6 ETO34163.1 - 2.9 7.9 7.7 4.6 7.3 1.3 2.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) PI3K_1B_p101 PF10486.9 ETO34165.1 - 1 7.1 4.7 1.2 6.9 4.7 1.0 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit CDC45 PF02724.14 ETO34167.1 - 0.037 12.3 10.8 0.23 9.7 1.7 2.3 2 0 0 2 2 2 0 CDC45-like protein Zip PF02535.22 ETO34167.1 - 1 8.5 5.4 3.1 6.9 0.9 2.4 2 0 0 2 2 2 0 ZIP Zinc transporter RR_TM4-6 PF06459.12 ETO34167.1 - 1.6 8.5 16.8 4.2 7.1 2.9 2.5 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF2201_N PF13203.6 ETO34167.1 - 4.3 6.8 11.1 2.7 7.5 1.1 2.4 2 0 0 2 2 2 0 Putative metallopeptidase domain MgtE PF01769.16 ETO34169.1 - 1.8 8.9 8.8 3.4 8.1 3.1 2.3 2 0 0 2 2 2 0 Divalent cation transporter FUSC_2 PF13515.6 ETO34169.1 - 2 8.6 13.3 2 8.6 3.4 2.5 2 1 0 2 2 2 0 Fusaric acid resistance protein-like TPR_2 PF07719.17 ETO34170.1 - 2e-05 24.4 2.2 2.1e-05 24.2 0.2 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34170.1 - 3.5e-05 23.4 0.3 7.8e-05 22.3 0.3 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO34170.1 - 0.011 16.5 0.6 0.041 14.7 0.0 2.3 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34170.1 - 0.014 15.5 0.1 0.014 15.5 0.1 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat G10 PF01125.17 ETO34170.1 - 0.12 12.2 2.3 0.65 9.7 0.3 2.3 2 0 0 2 2 2 0 G10 protein Csm1_N PF18504.1 ETO34170.1 - 4.3 7.7 7.8 0.68 10.3 1.8 2.7 3 0 0 3 3 3 0 Csm1 N-terminal domain Kinase-PPPase PF03618.14 ETO34171.1 - 0.00079 19.3 0.6 0.0075 16.1 0.3 2.2 2 0 0 2 2 2 1 Kinase/pyrophosphorylase MCPsignal PF00015.21 ETO34171.1 - 0.058 13.2 1.0 0.11 12.3 1.0 1.5 1 0 0 1 1 1 0 Methyl-accepting chemotaxis protein (MCP) signalling domain RRM_7 PF16367.5 ETO34171.1 - 0.14 12.3 0.4 19 5.5 0.1 2.8 2 0 0 2 2 2 0 RNA recognition motif SWIRM-assoc_1 PF16495.5 ETO34172.1 - 4.8e-10 39.3 5.5 4.8e-10 39.3 5.5 2.0 2 0 0 2 2 2 1 SWIRM-associated region 1 Myb_DNA-binding PF00249.31 ETO34172.1 - 0.003 17.7 0.1 0.0066 16.6 0.1 1.5 1 0 0 1 1 1 1 Myb-like DNA-binding domain Vps54_N PF10475.9 ETO34172.1 - 0.091 12.0 3.9 0.044 13.1 1.5 1.6 2 0 0 2 2 2 0 Vacuolar-sorting protein 54, of GARP complex ATP-synt_E PF05680.12 ETO34172.1 - 0.53 10.6 5.7 0.3 11.5 0.5 2.4 2 0 0 2 2 2 0 ATP synthase E chain SWIRM PF04433.17 ETO34173.1 - 0.00052 20.3 0.3 0.0016 18.7 0.1 1.9 2 0 0 2 2 2 1 SWIRM domain Adaptin_binding PF10199.9 ETO34174.1 - 0.022 15.4 0.1 0.041 14.5 0.1 1.5 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 SURF6 PF04935.12 ETO34174.1 - 0.97 9.2 5.3 0.24 11.2 1.0 1.9 2 0 0 2 2 2 0 Surfeit locus protein 6 Nckap1 PF09735.9 ETO34175.1 - 0.069 11.1 0.0 0.069 11.1 0.0 1.1 1 0 0 1 1 1 0 Membrane-associated apoptosis protein CRAL_TRIO PF00650.20 ETO34176.1 - 1.8e-09 37.5 1.5 1.2e-08 34.8 1.4 2.2 1 1 0 1 1 1 1 CRAL/TRIO domain CRAL_TRIO_2 PF13716.6 ETO34176.1 - 0.14 12.3 6.8 0.14 12.3 2.9 2.4 2 0 0 2 2 2 0 Divergent CRAL/TRIO domain XPC-binding PF09280.11 ETO34177.1 - 0.00014 21.5 23.1 0.017 14.8 7.7 2.5 2 0 0 2 2 2 2 XPC-binding domain STI1 PF17830.1 ETO34177.1 - 0.00021 21.2 17.3 0.0083 16.0 4.3 2.8 2 0 0 2 2 2 2 STI1 domain SOG2 PF10428.9 ETO34177.1 - 0.0046 16.2 35.1 0.0055 16.0 35.1 1.2 1 0 0 1 1 1 1 RAM signalling pathway protein GerD PF17898.1 ETO34177.1 - 0.014 15.3 1.1 0.014 15.3 1.1 2.5 2 0 0 2 2 2 0 Spore germination GerD central core domain TMEM232 PF15877.5 ETO34177.1 - 0.029 13.4 0.0 0.053 12.5 0.0 1.4 1 0 0 1 1 1 0 Transmembrane protein family 232 Utp14 PF04615.13 ETO34177.1 - 0.043 12.4 10.8 0.049 12.2 10.8 1.0 1 0 0 1 1 1 0 Utp14 protein HAP1_N PF04849.13 ETO34177.1 - 0.077 12.2 0.1 0.077 12.2 0.1 1.6 2 0 0 2 2 2 0 HAP1 N-terminal conserved region SPX PF03105.19 ETO34177.1 - 3.9 7.3 31.3 5.6 6.8 31.3 1.2 1 0 0 1 1 1 0 SPX domain DUF572 PF04502.13 ETO34177.1 - 4.5 6.8 18.6 6 6.4 18.6 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF572) Med13_C PF06333.12 ETO34177.1 - 4.6 6.4 29.1 7.7 5.7 29.1 1.4 1 0 0 1 1 1 0 Mediator complex subunit 13 C-terminal domain Med24_N PF11277.8 ETO34177.1 - 6.1 4.7 11.3 2.3 6.1 8.8 1.5 1 1 0 1 1 1 0 Mediator complex subunit 24 N-terminal DUF725 PF05267.12 ETO34178.1 - 0.83 9.7 10.7 0.088 12.8 2.7 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF725) ApoO PF09769.9 ETO34178.1 - 2.5 8.1 5.3 4 7.4 1.9 2.5 2 0 0 2 2 2 0 Apolipoprotein O DUF883 PF05957.13 ETO34178.1 - 3.2 8.4 6.7 1.1 9.9 2.8 2.2 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Kinesin PF00225.23 ETO34179.1 - 1.5e-37 129.3 0.2 1.9e-37 129.0 0.2 1.1 1 0 0 1 1 1 1 Kinesin motor domain HSP70 PF00012.20 ETO34179.1 - 0.092 10.9 0.0 0.15 10.3 0.0 1.3 1 0 0 1 1 1 0 Hsp70 protein DUF4208 PF13907.6 ETO34179.1 - 0.11 12.9 0.5 8.4 6.9 0.1 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4208) Lung_7-TM_R PF06814.13 ETO34180.1 - 3e-31 108.8 15.3 4.3e-31 108.3 15.3 1.2 1 0 0 1 1 1 1 Lung seven transmembrane receptor Spo7 PF03907.13 ETO34180.1 - 0.014 14.9 2.9 0.026 14.0 2.9 1.4 1 0 0 1 1 1 0 Spo7-like protein Osteopontin PF00865.18 ETO34180.1 - 2.2 7.7 20.1 3.1 7.2 20.1 1.1 1 0 0 1 1 1 0 Osteopontin Lung_7-TM_R PF06814.13 ETO34181.1 - 5.1e-11 42.4 0.9 6.2e-11 42.1 0.9 1.1 1 0 0 1 1 1 1 Lung seven transmembrane receptor Herpes_US9 PF06072.11 ETO34181.1 - 0.0059 16.5 0.0 0.013 15.4 0.0 1.5 1 0 0 1 1 1 1 Alphaherpesvirus tegument protein US9 AAA_33 PF13671.6 ETO34182.1 - 1.6e-05 25.1 0.1 3.9e-05 23.8 0.1 1.7 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO34182.1 - 0.012 16.2 2.4 0.038 14.6 2.4 2.0 1 1 0 1 1 1 0 AAA domain NACHT PF05729.12 ETO34182.1 - 0.052 13.5 0.1 0.13 12.2 0.1 1.7 1 0 0 1 1 1 0 NACHT domain AAA PF00004.29 ETO34182.1 - 0.091 13.2 0.2 0.35 11.3 0.0 2.0 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Tim54 PF11711.8 ETO34182.1 - 0.25 10.1 4.5 0.37 9.5 4.5 1.3 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Zip PF02535.22 ETO34182.1 - 0.28 10.3 2.8 0.38 9.9 2.8 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Connexin PF00029.19 ETO34182.1 - 0.3 10.8 3.2 0.49 10.1 3.2 1.3 1 0 0 1 1 1 0 Connexin Dsh_C PF12316.8 ETO34182.1 - 0.61 10.4 3.2 1.2 9.5 3.2 1.4 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal CPSF100_C PF13299.6 ETO34182.1 - 0.63 10.2 6.5 1.6 8.9 6.5 1.7 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_Rpc4 PF05132.14 ETO34182.1 - 1.7 9.1 7.6 3.6 8.0 7.6 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 EIIBC-GUT_N PF03612.14 ETO34182.1 - 2.2 8.0 6.4 3.9 7.2 6.4 1.3 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus Presenilin PF01080.17 ETO34182.1 - 4.9 5.8 7.8 6.7 5.4 7.8 1.2 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO34185.1 - 7e-68 222.9 23.6 4.1e-11 43.3 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34185.1 - 3.6e-21 75.3 5.9 0.00039 20.6 0.1 6.5 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34185.1 - 3.2e-10 39.8 10.1 0.00055 19.3 0.5 3.7 3 1 0 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO34185.1 - 5.8e-09 35.1 8.1 0.21 10.2 0.2 5.6 2 2 2 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO34185.1 - 7.3e-08 31.3 0.1 0.005 15.4 0.0 2.3 1 1 1 2 2 2 2 Cytochrome D1 heme domain VID27 PF08553.10 ETO34185.1 - 0.00031 19.9 1.1 0.043 12.9 0.1 3.3 1 1 3 4 4 4 2 VID27 C-terminal WD40-like domain NHL PF01436.21 ETO34185.1 - 0.0057 16.6 0.6 30 4.9 0.0 4.4 5 0 0 5 5 5 0 NHL repeat SBD PF17882.1 ETO34185.1 - 0.018 14.9 0.0 1.3 8.8 0.0 2.6 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain Str_synth PF03088.16 ETO34185.1 - 0.022 14.9 2.8 1.1 9.4 0.0 4.1 3 2 0 5 5 5 0 Strictosidine synthase Me-amine-dh_H PF06433.11 ETO34185.1 - 0.067 12.1 0.4 2.6 6.8 0.1 2.5 3 0 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) IBP39 PF11422.8 ETO34185.1 - 0.13 12.0 3.8 0.29 10.9 2.5 2.2 2 1 1 3 3 3 0 Initiator binding protein 39 kDa PD40 PF07676.12 ETO34185.1 - 0.32 11.0 6.9 49 4.0 0.0 5.4 6 1 0 6 6 6 0 WD40-like Beta Propeller Repeat GTP_EFTU PF00009.27 ETO34186.1 - 1.7e-32 112.5 0.1 2.6e-32 112.0 0.1 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain GTP_EFTU_D3 PF03143.17 ETO34186.1 - 1.9e-12 47.4 0.0 6.5e-12 45.7 0.0 1.9 1 0 0 1 1 1 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETO34186.1 - 1.8e-07 31.4 0.1 4.4e-07 30.2 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU_D4 PF14578.6 ETO34186.1 - 2.8e-05 23.9 0.1 6.3e-05 22.8 0.1 1.7 1 0 0 1 1 1 1 Elongation factor Tu domain 4 Arf PF00025.21 ETO34186.1 - 0.034 13.6 1.1 2.4 7.6 0.0 3.1 2 1 0 3 3 3 0 ADP-ribosylation factor family Kelch_6 PF13964.6 ETO34187.1 - 5.8e-05 23.2 0.7 1.8 9.0 0.0 4.7 3 1 1 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO34187.1 - 0.029 14.4 1.5 4.3 7.4 0.0 4.1 5 0 0 5 5 5 0 Kelch motif N_Asn_amidohyd PF14736.6 ETO34187.1 - 0.074 12.2 0.0 0.55 9.3 0.0 2.1 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase WD40 PF00400.32 ETO34188.1 - 1.5e-20 73.1 17.8 9.2e-07 29.5 2.4 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO34188.1 - 2.8e-06 26.3 2.5 0.0065 15.2 0.2 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34188.1 - 3.4e-06 27.2 0.3 0.08 13.3 0.0 2.5 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34188.1 - 0.00015 21.2 1.5 0.0044 16.4 0.7 2.3 1 1 1 2 2 2 2 WD40-like domain FUR PF01475.19 ETO34188.1 - 1.8 8.7 7.6 1 9.5 0.8 2.9 3 0 0 3 3 3 0 Ferric uptake regulator family Kinesin PF00225.23 ETO34189.1 - 1e-25 90.4 0.1 1.2e-25 90.1 0.1 1.1 1 0 0 1 1 1 1 Kinesin motor domain Microtub_bd PF16796.5 ETO34189.1 - 2.5e-17 63.2 0.1 6.1e-17 61.9 0.0 1.6 2 0 0 2 2 2 1 Microtubule binding CENP-B_dimeris PF09026.10 ETO34189.1 - 0.0077 16.6 2.8 0.014 15.8 2.8 1.4 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DUF4611 PF15387.6 ETO34189.1 - 0.091 13.0 2.8 0.15 12.3 2.8 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ETO34189.1 - 0.096 12.3 0.9 0.16 11.6 0.9 1.3 1 0 0 1 1 1 0 FAM176 family NOA36 PF06524.12 ETO34189.1 - 0.16 11.3 3.7 0.24 10.7 3.7 1.3 1 0 0 1 1 1 0 NOA36 protein Inositol_P PF00459.25 ETO34190.1 - 3.2e-15 56.4 0.0 4.3e-15 56.0 0.0 1.2 1 0 0 1 1 1 1 Inositol monophosphatase family Pox_polyA_pol_C PF12629.7 ETO34190.1 - 0.085 12.7 0.1 0.21 11.4 0.1 1.6 1 0 0 1 1 1 0 Poxvirus poly(A) polymerase C-terminal domain Glutaredoxin PF00462.24 ETO34191.1 - 1.6e-32 111.5 0.0 3.5e-15 56.0 0.0 3.4 3 0 0 3 3 3 2 Glutaredoxin Thioredoxin PF00085.20 ETO34191.1 - 2.1e-15 56.5 0.0 9.7e-15 54.4 0.0 2.1 2 0 0 2 2 2 1 Thioredoxin Thioredoxin_8 PF13905.6 ETO34191.1 - 1e-05 25.8 0.5 0.055 13.8 0.0 3.9 3 1 1 4 4 4 2 Thioredoxin-like Thioredoxin_2 PF13098.6 ETO34191.1 - 0.00066 20.1 0.3 0.039 14.4 0.0 3.4 3 1 0 3 3 3 1 Thioredoxin-like domain OST3_OST6 PF04756.13 ETO34191.1 - 0.0011 18.4 2.1 0.0039 16.6 0.0 2.2 2 0 0 2 2 2 1 OST3 / OST6 family, transporter family DUF656 PF04920.12 ETO34191.1 - 0.0019 18.1 0.0 0.44 10.5 0.0 2.3 2 0 0 2 2 2 2 Family of unknown function (DUF656) GST_N_3 PF13417.6 ETO34191.1 - 0.0059 17.0 0.0 5.9 7.4 0.0 2.6 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain HyaE PF07449.11 ETO34191.1 - 0.024 14.6 0.1 2.6 8.1 0.0 3.6 3 2 0 4 4 4 0 Hydrogenase-1 expression protein HyaE GN3L_Grn1 PF08701.11 ETO34191.1 - 0.045 13.8 0.8 0.11 12.6 0.8 1.6 1 0 0 1 1 1 0 GNL3L/Grn1 putative GTPase Endonuclease_5 PF04493.14 ETO34192.1 - 0.042 13.5 0.0 0.075 12.7 0.0 1.5 1 1 0 1 1 1 0 Endonuclease V G10 PF01125.17 ETO34192.1 - 0.18 11.6 1.4 0.56 10.0 0.1 1.9 1 1 1 2 2 2 0 G10 protein Crystall PF00030.19 ETO34193.1 - 0.079 13.2 0.0 7.2 6.9 0.0 2.9 2 0 0 2 2 2 0 Beta/Gamma crystallin WD40 PF00400.32 ETO34194.1 - 6.6e-53 175.5 20.6 1.8e-08 34.9 0.1 8.8 8 1 1 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34194.1 - 7.3e-16 58.2 4.7 0.00032 20.9 0.0 6.8 1 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34194.1 - 2e-05 24.1 12.1 0.004 16.5 0.3 3.5 1 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO34194.1 - 0.00032 20.6 12.8 0.33 10.9 0.1 6.5 9 0 0 9 9 9 2 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO34194.1 - 0.00044 19.7 2.2 0.32 10.3 0.0 4.6 1 1 2 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Mid2 PF04478.12 ETO34194.1 - 0.0026 17.6 1.2 3.3 7.5 0.1 3.8 3 1 1 4 4 4 1 Mid2 like cell wall stress sensor DUF4988 PF16378.5 ETO34194.1 - 0.0085 15.8 2.3 7.4 6.2 0.1 4.0 2 2 1 4 4 4 2 Domain of unknown function PQQ_2 PF13360.6 ETO34194.1 - 0.0094 15.5 0.0 0.17 11.4 0.0 2.6 1 1 1 2 2 2 2 PQQ-like domain DUF3475 PF11961.8 ETO34194.1 - 0.012 15.6 0.5 8.6 6.5 0.0 3.9 3 0 0 3 3 3 0 Domain of unknown function (DUF3475) CppA_N PF14506.6 ETO34194.1 - 0.16 12.0 0.0 1.4 9.0 0.0 2.5 4 0 0 4 4 4 0 CppA N-terminal WD40 PF00400.32 ETO34195.1 - 7.5e-129 415.9 55.8 3.4e-09 37.2 0.2 16.6 17 0 0 17 17 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34195.1 - 1.5e-35 121.3 18.2 0.00053 20.2 0.0 13.0 2 2 11 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34195.1 - 1.6e-20 73.3 2.9 0.093 11.7 0.0 12.0 2 2 8 12 12 12 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34195.1 - 1.9e-15 57.0 18.3 1.6e-05 24.4 0.1 7.4 4 3 4 8 8 8 6 WD40-like domain Nup160 PF11715.8 ETO34195.1 - 6e-12 45.0 27.7 0.56 8.8 0.0 12.3 2 2 10 12 12 12 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO34195.1 - 1.4e-07 31.3 11.4 6.7 6.8 0.0 8.9 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO34195.1 - 1.7e-07 31.2 0.9 6.4 7.0 0.0 7.3 6 2 0 7 7 7 2 Strictosidine synthase Pentapeptide PF00805.22 ETO34195.1 - 3.2e-07 29.9 1.8 6.9e-07 28.8 1.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Cytochrom_D1 PF02239.16 ETO34195.1 - 4.4e-07 28.8 6.9 0.0012 17.4 0.1 5.4 2 2 2 5 5 5 1 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETO34195.1 - 1.7e-05 24.9 0.4 5e-05 23.4 0.4 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PQQ_2 PF13360.6 ETO34195.1 - 3.9e-05 23.4 0.2 0.037 13.6 0.1 3.3 1 1 0 2 2 2 1 PQQ-like domain Mid2 PF04478.12 ETO34195.1 - 5.6e-05 23.0 7.8 9.1 6.1 0.0 6.9 5 2 2 7 7 6 1 Mid2 like cell wall stress sensor Pentapeptide_3 PF13576.6 ETO34195.1 - 0.0094 16.1 0.6 0.0094 16.1 0.6 2.1 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO34195.1 - 0.03 14.4 1.3 8.8 6.5 0.0 4.8 6 0 0 6 6 5 0 Domain of unknown function (DUF3475) DUF5570 PF17731.1 ETO34195.1 - 1 9.5 14.4 7.6 6.6 0.1 7.2 4 4 4 8 8 8 0 Family of unknown function (DUF5570) TPR_12 PF13424.6 ETO34196.1 - 4.4e-25 87.8 6.9 3.3e-09 36.9 0.5 4.7 3 2 1 5 5 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34196.1 - 2e-23 81.2 30.5 3.5e-06 26.6 1.9 6.2 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34196.1 - 5.5e-22 76.1 18.4 6.3e-05 22.8 0.3 6.2 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO34196.1 - 6.4e-16 57.7 0.2 0.00055 19.7 0.1 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34196.1 - 1e-15 56.5 6.7 0.0018 18.1 0.1 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34196.1 - 2.1e-15 55.6 30.5 0.00023 21.1 0.8 6.3 6 0 0 6 6 6 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO34196.1 - 1e-07 32.1 8.0 0.12 13.1 0.1 5.8 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34196.1 - 1.4e-06 28.2 9.2 2.2 8.8 0.2 6.3 6 0 0 6 6 6 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO34196.1 - 8.2e-06 26.2 0.0 9 7.4 0.1 5.3 5 1 1 6 6 6 0 Tetratricopeptide repeat TPR_16 PF13432.6 ETO34196.1 - 1.9e-05 25.2 0.0 0.45 11.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO34196.1 - 0.00016 21.8 13.7 0.023 14.9 4.6 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO34196.1 - 0.0017 18.8 0.2 0.66 10.5 0.1 3.8 3 1 1 4 4 4 1 Tetratricopeptide repeat DUF4810 PF16068.5 ETO34196.1 - 0.0031 18.0 3.3 44 4.7 0.0 5.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4810) TPR_11 PF13414.6 ETO34196.1 - 0.0049 16.5 26.3 0.98 9.2 0.1 7.2 7 1 1 8 8 8 3 TPR repeat MIT PF04212.18 ETO34196.1 - 0.0072 16.4 6.5 3.7 7.7 0.1 4.3 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETO34196.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.2 1 0 0 1 1 1 0 MalT-like TPR region SPO22 PF08631.10 ETO34196.1 - 0.032 13.7 6.4 0.3 10.5 0.0 3.2 1 1 2 3 3 3 0 Meiosis protein SPO22/ZIP4 like SRP_TPR_like PF17004.5 ETO34196.1 - 0.062 13.3 7.7 0.083 12.9 5.3 2.5 1 1 1 2 2 2 0 Putative TPR-like repeat Sel1 PF08238.12 ETO34196.1 - 0.25 12.1 15.0 1.8 9.4 0.2 5.9 5 2 0 5 5 5 0 Sel1 repeat HTH_Bact PF18768.1 ETO34196.1 - 1.7 8.3 16.3 3.4 7.3 0.1 4.9 6 0 0 6 6 6 0 Helix-turn-helix bacterial domain RVT_1 PF00078.27 ETO34197.1 - 3.9e-13 49.4 0.7 2.8e-06 27.0 0.0 3.4 2 1 1 3 3 3 3 Reverse transcriptase (RNA-dependent DNA polymerase) Topoisom_I PF01028.20 ETO34200.1 - 1.7e-90 302.4 7.9 1.7e-90 302.4 7.9 2.0 2 0 0 2 2 2 1 Eukaryotic DNA topoisomerase I, catalytic core Topoisom_I_N PF02919.15 ETO34200.1 - 4.4e-85 284.5 4.3 4.4e-85 284.5 4.3 3.6 3 1 2 5 5 5 1 Eukaryotic DNA topoisomerase I, DNA binding fragment Topo_C_assoc PF14370.6 ETO34200.1 - 1e-32 111.8 0.8 1e-32 111.8 0.8 2.3 2 0 0 2 2 2 1 C-terminal topoisomerase domain P_gingi_FimA PF06321.11 ETO34200.1 - 0.063 13.4 0.0 0.16 12.1 0.0 1.6 1 0 0 1 1 1 0 Major fimbrial subunit protein (FimA) Cep57_CLD_2 PF14197.6 ETO34200.1 - 1.2 9.3 7.9 2 8.6 2.9 2.9 2 1 0 2 2 2 0 Centrosome localisation domain of PPC89 PIN_5 PF08745.11 ETO34200.1 - 1.6 8.1 6.7 0.25 10.8 0.2 2.7 3 1 0 3 3 3 0 PINc domain ribonuclease DUF4407 PF14362.6 ETO34200.1 - 1.7 8.0 9.8 0.69 9.2 2.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4407) Afi1 PF07792.12 ETO34201.1 - 0.077 13.5 5.0 0.092 13.2 5.0 1.1 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking Connexin PF00029.19 ETO34201.1 - 0.082 12.7 2.2 0.086 12.6 2.2 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO34201.1 - 0.79 8.4 3.3 0.78 8.4 3.3 1.1 1 0 0 1 1 1 0 Presenilin OAD_gamma PF04277.13 ETO34201.1 - 8.7 7.0 6.7 7.1 7.3 4.8 1.9 1 1 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain WD40 PF00400.32 ETO34203.1 - 3.7e-41 138.3 24.1 2.5e-06 28.1 0.3 8.1 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34203.1 - 3.2e-13 49.8 1.5 0.016 15.5 0.0 6.0 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34203.1 - 7.6e-11 41.4 8.8 0.0074 15.0 0.1 5.1 1 1 2 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34203.1 - 4e-06 26.4 3.1 1.9 7.7 0.0 4.1 2 2 1 4 4 4 3 WD40-like domain Nucleoporin_N PF08801.11 ETO34203.1 - 8.8e-05 21.4 8.1 0.09 11.5 0.3 4.7 2 2 2 5 5 5 3 Nup133 N terminal like Thioredoxin_11 PF18078.1 ETO34203.1 - 0.034 14.3 0.5 12 6.0 0.0 2.6 2 0 0 2 2 2 0 Thioredoxin-like SNTX domain U-box PF04564.15 ETO34204.1 - 3.3e-09 36.8 0.0 1e-08 35.2 0.0 1.9 1 1 0 1 1 1 1 U-box domain APOBEC_N PF08210.11 ETO34204.1 - 0.049 13.5 0.6 0.063 13.2 0.6 1.1 1 0 0 1 1 1 0 APOBEC-like N-terminal domain Imm44 PF15571.6 ETO34205.1 - 0.015 15.5 1.4 0.015 15.5 1.4 1.6 2 0 0 2 2 2 0 Immunity protein 44 ANAPC4_WD40 PF12894.7 ETO34206.1 - 3.5e-08 33.6 0.5 0.54 10.6 0.2 4.9 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO34206.1 - 7.5e-07 28.9 2.2 0.022 14.7 0.0 5.3 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO34206.1 - 1.3e-05 25.8 0.0 0.17 12.8 0.0 5.1 5 0 0 5 5 5 1 WD domain, G-beta repeat WD40 PF00400.32 ETO34207.1 - 7.7e-108 349.4 45.8 4.3e-10 40.0 0.2 15.8 15 1 0 15 15 15 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34207.1 - 6.5e-29 100.1 12.3 0.023 15.0 0.0 11.3 2 1 8 10 10 10 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34207.1 - 3.1e-21 75.7 6.0 0.0013 17.8 0.0 11.4 1 1 8 11 11 11 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34207.1 - 4.9e-14 52.4 7.5 0.045 13.1 0.1 7.2 5 1 1 7 7 7 5 WD40-like domain NACHT PF05729.12 ETO34207.1 - 1.5e-09 38.0 0.0 2.6e-09 37.2 0.0 1.4 1 0 0 1 1 1 1 NACHT domain PQQ_2 PF13360.6 ETO34207.1 - 0.00075 19.1 0.3 0.01 15.5 0.1 2.7 3 1 0 3 3 3 1 PQQ-like domain AAA_18 PF13238.6 ETO34207.1 - 0.0008 20.0 0.1 0.0068 16.9 0.1 2.8 1 0 0 1 1 1 1 AAA domain RNA_helicase PF00910.22 ETO34207.1 - 0.019 15.3 0.0 1.1 9.7 0.0 3.2 2 0 0 2 2 2 0 RNA helicase PD40 PF07676.12 ETO34207.1 - 0.041 13.8 27.7 34 4.5 0.1 10.6 12 0 0 12 12 12 0 WD40-like Beta Propeller Repeat AAA PF00004.29 ETO34207.1 - 0.095 13.1 0.0 0.24 11.8 0.0 1.7 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO34207.1 - 0.12 12.7 0.5 0.55 10.5 0.1 2.4 2 1 0 2 2 1 0 AAA domain Inhibitor_I53 PF11714.8 ETO34207.1 - 0.15 12.3 0.1 0.4 10.9 0.1 1.6 1 0 0 1 1 1 0 Thrombin inhibitor Madanin Fibrinogen_aC PF12160.8 ETO34207.1 - 0.33 10.8 3.8 10 6.0 0.2 3.7 3 1 0 3 3 3 0 Fibrinogen alpha C domain Kelch_5 PF13854.6 ETO34208.1 - 0.0057 16.6 0.0 2.6 8.1 0.0 3.1 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO34208.1 - 0.0083 16.4 0.1 0.084 13.2 0.1 2.7 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO34208.1 - 0.086 12.8 0.4 1.4 9.0 0.0 2.9 3 1 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO34209.1 - 2.6e-59 195.8 16.9 6.8e-09 36.2 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34209.1 - 2.8e-27 94.8 3.3 0.0014 18.9 0.1 7.1 1 1 6 7 7 7 7 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34209.1 - 3e-16 59.6 2.0 0.00021 20.7 0.0 4.4 1 1 3 4 4 4 4 WD40-like domain Ge1_WD40 PF16529.5 ETO34209.1 - 4.4e-15 55.5 0.1 0.005 15.8 0.0 6.4 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO34209.1 - 2.7e-09 36.2 3.1 0.15 10.7 0.0 5.9 1 1 4 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO34209.1 - 7.8e-07 28.9 3.6 13 5.9 0.0 6.1 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO34209.1 - 5.8e-06 25.3 8.1 0.03 13.1 0.4 4.7 1 1 4 5 5 5 2 Nup133 N terminal like DUF5570 PF17731.1 ETO34209.1 - 1.2e-05 25.4 1.4 12 6.0 0.0 5.2 1 1 5 6 6 6 0 Family of unknown function (DUF5570) PQQ PF01011.21 ETO34209.1 - 5.5e-05 22.9 0.0 5 7.2 0.0 4.9 5 0 0 5 5 5 1 PQQ enzyme repeat Ricin_B_lectin PF00652.22 ETO34209.1 - 9.9e-05 22.6 1.5 0.39 11.0 2.0 3.3 1 1 1 3 3 3 1 Ricin-type beta-trefoil lectin domain Cytochrom_D1 PF02239.16 ETO34209.1 - 0.00013 20.7 0.9 0.0037 15.8 0.0 2.6 1 1 0 3 3 3 1 Cytochrome D1 heme domain PQQ_2 PF13360.6 ETO34209.1 - 0.00022 20.9 0.2 0.0073 15.9 0.2 2.8 1 1 0 1 1 1 1 PQQ-like domain Nbas_N PF15492.6 ETO34209.1 - 0.00023 20.6 0.5 0.23 10.8 0.0 3.7 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal DUF5449 PF17528.2 ETO34209.1 - 0.013 15.2 1.9 2.9 7.6 0.0 3.7 2 2 1 3 3 3 0 Family of unknown function (DUF5449) DUF1797 PF08796.10 ETO34209.1 - 0.018 15.1 0.0 9.8 6.3 0.0 3.3 2 2 1 3 3 3 0 Protein of unknown function (DUF1797) Proteasome_A_N PF10584.9 ETO34209.1 - 0.019 14.6 7.9 28 4.5 0.0 6.2 7 0 0 7 7 7 0 Proteasome subunit A N-terminal signature VID27 PF08553.10 ETO34209.1 - 0.04 13.0 0.0 0.21 10.6 0.0 2.1 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain Resistin PF06954.11 ETO34209.1 - 0.11 13.0 1.4 78 3.9 0.0 3.9 2 1 2 4 4 4 0 Resistin NHL PF01436.21 ETO34209.1 - 0.26 11.4 7.2 6.2 7.0 0.0 4.5 5 0 0 5 5 4 0 NHL repeat WD40 PF00400.32 ETO34210.1 - 7.7e-09 36.1 8.9 8.5e-05 23.3 0.7 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat Kelch_2 PF07646.15 ETO34211.1 - 0.00086 19.2 4.1 0.67 10.0 0.3 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO34211.1 - 0.0011 18.9 1.5 11 6.2 0.0 4.9 6 0 0 6 6 6 2 Kelch motif Kelch_1 PF01344.25 ETO34211.1 - 0.0011 18.4 4.0 0.22 11.2 0.1 4.7 5 1 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO34211.1 - 0.024 14.6 0.1 0.35 10.9 0.0 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain WD40 PF00400.32 ETO34212.1 - 9.2e-23 80.1 18.7 3.6e-05 24.4 0.4 6.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34212.1 - 7.8e-08 32.5 2.6 0.29 11.5 0.2 5.3 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34212.1 - 1.7e-07 30.3 8.7 0.00065 18.5 2.4 4.5 1 1 2 4 4 4 4 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO34212.1 - 0.0042 16.7 0.5 0.0042 16.7 0.5 2.3 2 1 0 2 2 2 1 Domain of unknown function (DUF4221) WD40 PF00400.32 ETO34214.1 - 9.7e-23 80.0 13.6 1.3e-05 25.9 0.4 5.6 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34214.1 - 6.2e-10 39.3 0.5 0.0019 18.5 0.0 3.5 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34214.1 - 8.2e-09 34.6 1.5 0.021 13.5 0.1 3.3 1 1 1 3 3 3 3 Nucleoporin Nup120/160 PQQ_3 PF13570.6 ETO34214.1 - 0.096 13.2 1.2 76 4.0 0.0 3.3 3 0 0 3 3 3 0 PQQ-like domain Kelch_5 PF13854.6 ETO34215.1 - 2.8e-05 24.0 0.2 0.036 14.1 0.1 2.3 2 0 0 2 2 2 2 Kelch motif Kelch_6 PF13964.6 ETO34215.1 - 0.013 15.8 0.2 0.43 10.9 0.0 2.3 2 0 0 2 2 2 0 Kelch motif GF_recep_IV PF14843.6 ETO34215.1 - 0.013 15.3 0.4 0.015 15.1 0.4 1.1 1 0 0 1 1 1 0 Growth factor receptor domain IV Kelch_2 PF07646.15 ETO34215.1 - 0.081 12.9 0.2 1.1 9.3 0.1 2.3 2 0 0 2 2 2 0 Kelch motif APG6_N PF17675.1 ETO34216.1 - 4.1 7.9 36.7 0.18 12.3 4.3 3.4 1 1 1 3 3 3 0 Apg6 coiled-coil region FXMRP1_C_core PF12235.8 ETO34216.1 - 8 7.1 12.6 0.2 12.3 3.3 2.8 2 1 1 3 3 3 0 Fragile X-related 1 protein core C terminal Kinesin PF00225.23 ETO34218.1 - 1.1e-23 83.7 2.7 1.1e-23 83.7 2.7 1.8 2 0 0 2 2 2 1 Kinesin motor domain RVT_1 PF00078.27 ETO34218.1 - 2.4e-13 50.1 0.0 5.6e-10 39.1 0.0 2.9 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Microtub_bd PF16796.5 ETO34218.1 - 2e-11 44.0 1.2 5.5e-11 42.6 1.2 1.8 1 0 0 1 1 1 1 Microtubule binding zf-BED PF02892.15 ETO34218.1 - 0.0017 18.3 0.2 0.0065 16.5 0.2 2.0 1 0 0 1 1 1 1 BED zinc finger Mu-like_Com PF10122.9 ETO34218.1 - 0.15 11.5 0.2 0.36 10.3 0.2 1.6 1 0 0 1 1 1 0 Mu-like prophage protein Com MMS1_N PF10433.9 ETO34219.1 - 0.065 11.8 0.0 0.1 11.2 0.0 1.3 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term 7tm_1 PF00001.21 ETO34220.1 - 0.045 13.1 0.3 0.067 12.5 0.3 1.4 1 0 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Mito_carr PF00153.27 ETO34221.1 - 1.7e-38 130.4 6.5 1.6e-14 53.5 0.1 4.2 4 0 0 4 4 4 4 Mitochondrial carrier protein Ank_3 PF13606.6 ETO34223.1 - 1.2e-05 25.3 0.9 0.00015 21.9 0.1 2.7 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETO34223.1 - 1.9e-05 24.9 0.0 3e-05 24.2 0.0 1.4 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO34223.1 - 0.0016 19.0 0.1 0.0032 18.0 0.0 1.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO34223.1 - 0.0056 17.1 0.4 0.015 15.8 0.0 1.9 2 1 0 2 2 2 1 Ankyrin repeat Herpes_U34 PF04541.13 ETO34223.1 - 0.11 11.8 0.0 0.13 11.5 0.0 1.2 1 0 0 1 1 1 0 Herpesvirus virion protein U34 WD40 PF00400.32 ETO34226.1 - 0.0023 18.7 2.3 0.3 12.0 0.1 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat Sporozoite_P67 PF05642.11 ETO34227.1 - 0.0044 15.2 0.6 0.0046 15.1 0.6 1.0 1 0 0 1 1 1 1 Sporozoite P67 surface antigen FAM176 PF14851.6 ETO34227.1 - 0.0058 16.3 1.8 0.0069 16.1 1.8 1.1 1 0 0 1 1 1 1 FAM176 family DUF2154 PF09922.9 ETO34227.1 - 0.099 12.5 0.5 0.15 12.0 0.5 1.3 1 1 0 1 1 1 0 Cell wall-active antibiotics response 4TMS YvqF Protocadherin PF08374.11 ETO34227.1 - 0.15 12.0 5.4 0.16 11.9 5.4 1.1 1 0 0 1 1 1 0 Protocadherin Kelch_6 PF13964.6 ETO34228.1 - 0.00038 20.6 4.3 0.017 15.4 0.2 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO34228.1 - 0.00067 19.6 0.4 0.0096 15.9 0.1 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO34228.1 - 0.0054 16.3 0.1 0.11 12.1 0.0 2.9 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO34228.1 - 0.088 12.8 0.2 0.41 10.7 0.2 2.3 1 0 0 1 1 1 0 Kelch motif Kelch_2 PF07646.15 ETO34228.1 - 0.1 12.6 4.9 0.59 10.2 0.1 3.6 3 1 1 4 4 4 0 Kelch motif WD40 PF00400.32 ETO34229.1 - 0.002 18.9 2.6 1.2 10.1 0.1 2.9 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO34229.1 - 0.014 14.7 0.1 0.22 10.8 0.0 2.1 2 0 0 2 2 2 0 WD40-like domain ANAPC4_WD40 PF12894.7 ETO34229.1 - 0.023 15.0 0.0 1 9.7 0.0 2.4 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Kinesin PF00225.23 ETO34230.1 - 0.011 14.7 0.0 0.013 14.5 0.0 1.1 1 0 0 1 1 1 0 Kinesin motor domain Toluene_X PF03349.16 ETO34232.1 - 0.053 12.1 0.1 0.09 11.3 0.1 1.3 1 0 0 1 1 1 0 Outer membrane protein transport protein (OMPP1/FadL/TodX) DUF3502 PF12010.8 ETO34234.1 - 0.0058 17.3 0.3 0.0083 16.8 0.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF3502) DUF778 PF05608.12 ETO34234.1 - 0.027 14.8 0.0 0.033 14.6 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF778) zf-piccolo PF05715.13 ETO34234.1 - 0.083 13.0 0.3 0.22 11.7 0.0 1.8 2 0 0 2 2 2 0 Piccolo Zn-finger YvfG PF09628.10 ETO34235.1 - 0.051 13.9 0.2 0.082 13.3 0.2 1.4 1 1 0 1 1 1 0 YvfG protein CxC1 PF18802.1 ETO34236.1 - 0.011 15.9 2.1 0.093 12.9 0.6 2.5 2 1 0 2 2 2 0 CxC1 like cysteine cluster associated with KDZ transposases G-alpha PF00503.20 ETO34237.1 - 7.1e-30 104.4 0.7 8.9e-30 104.0 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO34237.1 - 6.9e-05 22.4 0.3 0.00014 21.4 0.3 1.4 1 1 0 1 1 1 1 ADP-ribosylation factor family zf-RanBP PF00641.18 ETO34238.1 - 2.1e-06 26.9 1.8 4.7e-06 25.8 1.8 1.6 1 0 0 1 1 1 1 Zn-finger in Ran binding protein and others SR-25 PF10500.9 ETO34238.1 - 0.0073 15.9 21.8 0.0073 15.9 21.8 3.1 1 1 0 2 2 2 1 Nuclear RNA-splicing-associated protein Vps36-NZF-N PF16988.5 ETO34238.1 - 0.11 11.9 1.2 0.41 10.1 1.2 2.0 1 0 0 1 1 1 0 Vacuolar protein sorting 36 NZF-N zinc-finger domain V_ATPase_I PF01496.19 ETO34238.1 - 5.1 4.9 20.8 2.4 6.0 12.8 2.3 2 0 0 2 2 2 0 V-type ATPase 116kDa subunit family Ion_trans PF00520.31 ETO34239.1 - 7.2e-38 130.2 14.5 1e-37 129.7 14.5 1.2 1 0 0 1 1 1 1 Ion transport protein PKD_channel PF08016.12 ETO34239.1 - 7.4e-06 24.9 10.5 1.7e-05 23.7 10.6 1.5 1 1 0 1 1 1 1 Polycystin cation channel GPHH PF16905.5 ETO34239.1 - 0.0003 20.5 0.2 0.004 16.9 0.0 2.3 2 0 0 2 2 2 1 Voltage-dependent L-type calcium channel, IQ-associated OHA PF14418.6 ETO34239.1 - 0.12 12.2 0.0 0.26 11.1 0.0 1.5 1 0 0 1 1 1 0 OST-HTH Associated domain DUF2189 PF09955.9 ETO34239.1 - 0.19 12.0 4.9 0.31 11.3 2.3 2.2 1 1 1 2 2 2 0 Predicted integral membrane protein (DUF2189) WD40 PF00400.32 ETO34240.1 - 2.5e-08 34.4 0.9 4.7e-07 30.4 0.1 2.5 2 1 0 2 2 2 1 WD domain, G-beta repeat Beta_helix PF13229.6 ETO34240.1 - 0.014 15.2 2.3 0.02 14.8 2.3 1.2 1 0 0 1 1 1 0 Right handed beta helix region WD40 PF00400.32 ETO34241.1 - 4e-60 198.3 20.5 3.7e-09 37.0 0.5 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34241.1 - 1.6e-25 89.2 2.4 0.0039 17.5 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34241.1 - 1.5e-14 54.0 3.0 0.00016 21.1 0.1 3.5 2 1 1 3 3 3 3 WD40-like domain eIF2A PF08662.11 ETO34241.1 - 1.6e-11 44.5 0.3 0.0004 20.3 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO34241.1 - 5.5e-09 35.4 0.1 0.94 8.4 0.0 5.6 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO34241.1 - 3.1e-07 29.3 1.4 0.16 10.4 0.1 3.1 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO34241.1 - 6.6e-07 29.1 1.3 3.3 7.8 0.0 6.0 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO34241.1 - 1.8e-06 26.9 1.8 1.6 7.3 0.0 5.0 2 2 1 5 5 5 1 Nucleoporin Nup120/160 DUF5046 PF16465.5 ETO34241.1 - 7.3e-05 22.3 0.0 0.048 13.1 0.0 2.7 1 1 2 3 3 3 2 Domain of unknown function (DUF5046) DUF5570 PF17731.1 ETO34241.1 - 0.00026 21.1 0.6 3.4 7.8 0.0 4.3 3 2 1 4 4 4 1 Family of unknown function (DUF5570) PQQ PF01011.21 ETO34241.1 - 0.0004 20.2 0.0 12 6.0 0.0 4.8 5 0 0 5 5 5 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO34241.1 - 0.00043 19.1 7.6 0.092 11.5 1.1 4.5 1 1 2 4 4 4 1 Nup133 N terminal like PALB2_WD40 PF16756.5 ETO34241.1 - 0.0013 17.7 0.7 0.63 8.9 0.1 4.1 3 2 2 5 5 5 1 Partner and localizer of BRCA2 WD40 domain PQQ_2 PF13360.6 ETO34241.1 - 0.0024 17.5 0.3 0.1 12.2 0.1 2.9 1 1 1 2 2 2 1 PQQ-like domain DUF5449 PF17528.2 ETO34241.1 - 0.0047 16.7 0.1 0.22 11.3 0.0 2.8 1 1 1 3 3 3 1 Family of unknown function (DUF5449) HPS6 PF15702.5 ETO34241.1 - 0.043 11.8 0.0 1.4 6.8 0.0 3.2 3 1 2 5 5 5 0 Hermansky-Pudlak syndrome 6 protein Proteasome_A_N PF10584.9 ETO34241.1 - 0.044 13.5 4.1 14 5.5 0.0 3.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Phage_CI_repr PF07022.13 ETO34241.1 - 0.076 13.1 0.0 5.7 7.1 0.0 2.9 3 0 0 3 3 3 0 Bacteriophage CI repressor helix-turn-helix domain Prot_ATP_ID_OB PF16450.5 ETO34241.1 - 0.095 12.7 0.4 19 5.3 0.0 3.6 3 1 0 3 3 3 0 Proteasomal ATPase OB C-terminal domain DUF5122 PF17164.4 ETO34241.1 - 0.15 12.4 3.9 32 4.9 0.0 4.6 5 0 0 5 5 5 0 Domain of unknown function (DUF5122) beta-propeller WD40 PF00400.32 ETO34242.1 - 3.7e-39 132.0 22.3 7.3e-07 29.8 1.5 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34242.1 - 5.6e-14 52.2 4.0 0.077 13.3 0.0 6.7 6 2 1 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34242.1 - 2.9e-12 46.1 7.0 0.0062 15.2 0.1 5.5 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34242.1 - 5.5e-09 35.8 3.9 4.2e-05 23.0 0.2 4.7 3 2 1 4 4 4 2 WD40-like domain fn3_PAP PF17808.1 ETO34242.1 - 0.013 15.6 0.3 11 6.2 0.0 4.0 2 1 2 4 4 4 0 Fn3-like domain from Purple Acid Phosphatase Cu-oxidase_2 PF07731.14 ETO34242.1 - 0.029 14.1 0.0 0.061 13.1 0.0 1.5 1 0 0 1 1 1 0 Multicopper oxidase Golgin_A5 PF09787.9 ETO34242.1 - 1.7 8.1 16.4 2.5 7.5 16.4 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 DUF3584 PF12128.8 ETO34242.1 - 7.4 3.9 16.4 10 3.5 16.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3584) Zip PF02535.22 ETO34243.1 - 0.055 12.7 0.2 0.06 12.6 0.2 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter OAD_gamma PF04277.13 ETO34243.1 - 0.057 14.0 1.8 0.47 11.1 0.0 2.3 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain DUF4093 PF13331.6 ETO34243.1 - 0.079 13.4 0.1 0.12 12.8 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4093) Spo7 PF03907.13 ETO34243.1 - 0.089 12.3 0.7 0.14 11.7 0.7 1.2 1 0 0 1 1 1 0 Spo7-like protein Ctr PF04145.15 ETO34243.1 - 0.12 13.0 0.3 0.17 12.5 0.3 1.3 1 1 0 1 1 1 0 Ctr copper transporter family Secretin_N_2 PF07655.13 ETO34244.1 - 0.0017 18.9 5.4 0.0022 18.5 5.4 1.3 1 0 0 1 1 1 1 Secretin N-terminal domain DUF5389 PF17364.2 ETO34244.1 - 0.0073 16.3 0.1 0.016 15.3 0.1 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5389) Orf78 PF06024.12 ETO34244.1 - 0.019 15.3 1.3 0.024 14.9 1.3 1.2 1 0 0 1 1 1 0 Orf78 (ac78) STT3 PF02516.14 ETO34244.1 - 0.041 12.8 0.2 0.045 12.7 0.2 1.0 1 0 0 1 1 1 0 Oligosaccharyl transferase STT3 subunit Peroxin-13_N PF04088.13 ETO34244.1 - 0.083 13.2 0.2 0.096 13.0 0.2 1.1 1 0 0 1 1 1 0 Peroxin 13, N-terminal region DUF4834 PF16118.5 ETO34244.1 - 0.098 13.6 1.3 0.15 13.1 1.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FAM221 PF14753.6 ETO34245.1 - 0.026 14.1 6.9 0.038 13.5 6.4 1.6 1 1 0 1 1 1 0 Protein FAM221A/B DUF4551 PF15087.6 ETO34245.1 - 7.4 5.3 16.0 8.5 5.1 16.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) HPIH PF13323.6 ETO34247.1 - 0.091 12.6 1.8 0.16 11.8 0.4 2.0 1 1 1 2 2 2 0 N-terminal domain with HPIH motif ComS PF17584.2 ETO34248.1 - 0.096 12.2 0.6 6.3 6.4 0.0 2.5 2 0 0 2 2 2 0 Bacillus competence protein S Poxvirus_B22R PF04395.12 ETO34249.1 - 0.027 14.0 6.2 0.049 13.2 6.2 1.4 1 0 0 1 1 1 0 Poxvirus B22R protein EbsA PF17255.2 ETO34249.1 - 1.1 9.6 4.4 4.2 7.7 0.0 2.7 3 0 0 3 3 3 0 EbsA-like protein YtpI PF14007.6 ETO34249.1 - 2.2 8.5 9.5 3.8 7.7 0.2 3.3 3 0 0 3 3 3 0 YtpI-like protein Cys_knot PF00007.22 ETO34249.1 - 2.6 8.4 9.7 3.3 8.1 0.2 2.7 2 1 0 2 2 2 0 Cystine-knot domain DUF4574 PF15141.6 ETO34250.1 - 0.086 12.8 0.2 0.13 12.2 0.2 1.3 1 0 0 1 1 1 0 Ubiquinol-cytochrome-c reductase complex assembly factor 3 DUF443 PF04276.12 ETO34250.1 - 0.14 11.9 4.0 0.083 12.7 2.4 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF443) EphA2_TM PF14575.6 ETO34250.1 - 0.88 10.5 3.6 2.4 9.1 3.6 1.7 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DnaJ PF00226.31 ETO34251.1 - 0.031 14.4 2.0 0.031 14.4 2.0 1.8 2 0 0 2 2 2 0 DnaJ domain TBCA PF02970.16 ETO34252.1 - 0.003 17.8 0.0 0.0096 16.2 0.0 1.9 1 1 0 1 1 1 1 Tubulin binding cofactor A HAD_SAK_2 PF18143.1 ETO34252.1 - 0.007 16.7 0.3 0.021 15.2 0.2 1.8 1 1 0 1 1 1 1 HAD domain in Swiss Army Knife RNA repair proteins His_kinase PF06580.13 ETO34252.1 - 0.049 14.0 0.2 0.21 11.9 0.2 2.1 1 0 0 1 1 1 0 Histidine kinase TLD PF07534.16 ETO34253.1 - 1.5e-07 31.7 0.3 3e-07 30.7 0.3 1.6 1 0 0 1 1 1 1 TLD Amidase_2 PF01510.25 ETO34254.1 - 0.018 15.5 0.5 0.024 15.1 0.5 1.3 1 0 0 1 1 1 0 N-acetylmuramoyl-L-alanine amidase DUF2393 PF09624.10 ETO34254.1 - 0.038 14.0 1.3 0.038 14.0 1.3 1.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2393) MRF_C1 PF13887.6 ETO34254.1 - 0.085 12.0 0.2 0.22 10.7 0.2 1.7 1 0 0 1 1 1 0 Myelin gene regulatory factor -C-terminal domain 1 FAM76 PF16046.5 ETO34254.1 - 3.3 7.0 17.0 1.5 8.1 14.8 1.5 1 1 1 2 2 2 0 FAM76 protein Myc_N PF01056.18 ETO34255.1 - 0.13 12.1 10.8 0.18 11.7 10.8 1.1 1 0 0 1 1 1 0 Myc amino-terminal region Peptidase_M24 PF00557.24 ETO34256.1 - 1.6e-20 73.7 0.0 8.2e-12 45.2 0.0 2.3 2 0 0 2 2 2 2 Metallopeptidase family M24 AMP_N PF05195.16 ETO34256.1 - 2e-17 63.1 0.0 3.4e-17 62.3 0.0 1.3 1 0 0 1 1 1 1 Aminopeptidase P, N-terminal domain NUC153 PF08159.12 ETO34258.1 - 2.2e-08 33.7 1.4 5e-08 32.6 1.4 1.6 1 0 0 1 1 1 1 NUC153 domain ANAPC4_WD40 PF12894.7 ETO34258.1 - 0.012 15.9 0.0 0.032 14.5 0.0 1.7 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO34258.1 - 0.02 15.8 3.5 0.46 11.4 0.3 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat MHB PF16525.5 ETO34258.1 - 0.095 13.0 0.0 0.25 11.6 0.0 1.6 1 0 0 1 1 1 0 Haemophore, haem-binding DAPDH_C PF16654.5 ETO34258.1 - 0.18 11.6 1.2 0.73 9.7 0.0 2.3 2 0 0 2 2 2 0 Diaminopimelic acid dehydrogenase C-terminal domain Macoilin PF09726.9 ETO34259.1 - 1.8 7.0 25.7 2.3 6.7 25.7 1.3 1 0 0 1 1 1 0 Macoilin family Podoplanin PF05808.11 ETO34259.1 - 8.5 6.5 12.5 11 6.1 10.6 2.2 1 1 1 2 2 2 0 Podoplanin Peptidase_M24 PF00557.24 ETO34260.1 - 0.0037 17.0 0.0 0.0052 16.5 0.0 1.2 1 0 0 1 1 1 1 Metallopeptidase family M24 Med25_VWA PF11265.8 ETO34262.1 - 0.056 13.2 0.0 0.1 12.4 0.0 1.3 1 0 0 1 1 1 0 Mediator complex subunit 25 von Willebrand factor type A Rubella_E2 PF05749.11 ETO34263.1 - 4.9 6.5 11.0 0.93 8.9 5.6 2.6 2 0 0 2 2 2 0 Rubella membrane glycoprotein E2 WD40_3 PF15911.5 ETO34264.1 - 3.4e-10 39.8 0.1 1e-08 35.0 0.1 2.8 1 1 0 1 1 1 1 WD domain, G-beta repeat DUF2039 PF10217.9 ETO34264.1 - 0.0023 18.3 0.4 0.0076 16.6 0.4 1.9 1 0 0 1 1 1 1 Uncharacterized conserved protein (DUF2039) TPR_MalT PF17874.1 ETO34264.1 - 0.0045 16.4 0.5 0.0074 15.7 0.5 1.2 1 0 0 1 1 1 1 MalT-like TPR region MIT PF04212.18 ETO34264.1 - 0.025 14.7 0.2 0.076 13.1 0.2 1.8 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 ETO34264.1 - 0.23 11.8 2.4 8.9 6.7 0.3 2.8 2 1 0 2 2 2 0 Tetratricopeptide repeat NHL PF01436.21 ETO34264.1 - 0.44 10.7 2.1 0.66 10.1 0.1 2.4 2 0 0 2 2 2 0 NHL repeat TPR_7 PF13176.6 ETO34264.1 - 0.52 10.5 2.2 3.3 7.9 0.1 2.9 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34264.1 - 0.62 10.0 6.2 0.41 10.6 0.6 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34264.1 - 1 9.7 8.3 0.23 11.6 0.3 3.5 4 0 0 4 4 4 0 Tetratricopeptide repeat ANAPC4_WD40 PF12894.7 ETO34265.1 - 5.1e-06 26.7 0.4 0.011 16.0 0.0 3.2 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain CHU_C PF13585.6 ETO34265.1 - 0.071 13.2 0.8 0.22 11.6 0.0 2.2 2 0 0 2 2 2 0 C-terminal domain of CHU protein family FlgD_ig PF13860.6 ETO34265.1 - 0.17 11.8 0.0 0.64 9.9 0.0 1.8 2 0 0 2 2 2 0 FlgD Ig-like domain EMP24_GP25L PF01105.24 ETO34266.1 - 7.7e-25 87.9 0.5 1.2e-24 87.2 0.2 1.4 1 1 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DAAD PF18752.1 ETO34267.1 - 0.0031 17.4 1.9 0.0045 16.9 1.9 1.2 1 0 0 1 1 1 1 Dictyosteliid AID/APOBEC-like Deaminase DUF913 PF06025.12 ETO34267.1 - 0.15 11.0 2.4 0.26 10.2 2.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) RGS PF00615.19 ETO34267.1 - 1.1 9.5 4.7 3.2 8.1 0.2 2.9 2 1 0 2 2 2 0 Regulator of G protein signaling domain tRNA-synt_2 PF00152.20 ETO34268.1 - 1.6e-55 188.4 0.2 2e-55 188.1 0.2 1.1 1 0 0 1 1 1 1 tRNA synthetases class II (D, K and N) tRNA-synt_2 PF00152.20 ETO34269.1 - 3.8e-11 42.6 11.2 2.8e-10 39.8 0.6 2.6 2 1 1 3 3 3 2 tRNA synthetases class II (D, K and N) tRNA_anti-codon PF01336.25 ETO34269.1 - 1.4e-09 37.8 0.0 2.9e-09 36.8 0.0 1.5 1 0 0 1 1 1 1 OB-fold nucleic acid binding domain tRNA_anti-like PF12869.7 ETO34269.1 - 0.0029 17.2 0.0 0.16 11.6 0.0 2.3 2 0 0 2 2 2 1 tRNA_anti-like ANAPC3 PF12895.7 ETO34271.1 - 0.0075 16.5 0.0 1 9.6 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 SLC12 PF03522.15 ETO34272.1 - 0.029 13.4 0.1 0.032 13.3 0.1 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Kelch_6 PF13964.6 ETO34273.1 - 3.9e-07 30.1 0.3 0.0081 16.4 0.1 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_2 PF07646.15 ETO34273.1 - 5.7e-06 26.1 0.1 0.002 18.0 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_4 PF13418.6 ETO34273.1 - 1.2e-05 25.2 0.1 0.01 15.8 0.1 2.4 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO34273.1 - 6.2e-05 22.5 0.2 0.0046 16.5 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO34273.1 - 0.097 12.7 0.2 3.7 7.7 0.2 2.4 2 0 0 2 2 2 0 Kelch motif Herpes_UL3 PF03369.13 ETO34273.1 - 0.14 12.7 0.2 0.25 11.9 0.2 1.3 1 0 0 1 1 1 0 Herpesvirus UL3 protein XPA_C PF05181.12 ETO34273.1 - 0.16 12.0 1.7 0.31 11.0 1.7 1.5 1 0 0 1 1 1 0 XPA protein C-terminus WD40 PF00400.32 ETO34275.1 - 2.1e-44 148.6 12.0 1.2e-09 38.6 0.3 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34275.1 - 2.1e-15 56.8 1.0 0.015 15.6 0.0 4.7 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34275.1 - 3.7e-07 29.8 7.8 0.0013 18.2 0.4 3.6 2 2 2 4 4 4 2 WD40-like domain Ge1_WD40 PF16529.5 ETO34275.1 - 1.8e-06 27.1 1.8 0.64 8.9 0.0 4.3 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO34275.1 - 0.00027 19.6 0.6 0.00076 18.1 0.0 2.1 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO34275.1 - 0.00028 19.7 0.5 0.87 8.1 0.1 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO34275.1 - 0.0012 17.7 6.9 0.0057 15.4 1.9 2.8 1 1 2 3 3 3 1 Nup133 N terminal like PD40 PF07676.12 ETO34275.1 - 0.0019 18.1 0.3 8.5 6.5 0.0 3.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Thioredoxin_2 PF13098.6 ETO34275.1 - 0.071 13.6 0.1 0.35 11.4 0.1 2.0 2 0 0 2 2 2 0 Thioredoxin-like domain Proteasome_A_N PF10584.9 ETO34275.1 - 0.31 10.7 2.4 16 5.3 0.2 2.9 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature Ras PF00071.22 ETO34276.1 - 3.5e-22 78.7 1.0 6.5e-22 77.8 1.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO34276.1 - 2.8e-08 34.0 0.1 5.3e-08 33.1 0.1 1.5 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase DLIC PF05783.11 ETO34276.1 - 0.0029 16.5 0.3 0.0041 16.0 0.3 1.2 1 0 0 1 1 1 1 Dynein light intermediate chain (DLIC) Arf PF00025.21 ETO34276.1 - 0.02 14.3 0.1 0.032 13.7 0.1 1.3 1 0 0 1 1 1 0 ADP-ribosylation factor family OKR_DC_1_N PF03709.15 ETO34276.1 - 0.023 15.0 0.0 0.051 13.9 0.0 1.6 1 1 0 1 1 1 0 Orn/Lys/Arg decarboxylase, N-terminal domain Metallophos PF00149.28 ETO34281.1 - 0.00072 20.1 8.2 0.0046 17.5 8.2 2.1 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Phi_1 PF04674.12 ETO34284.1 - 0.17 11.1 0.9 0.2 10.9 0.9 1.1 1 0 0 1 1 1 0 Phosphate-induced protein 1 conserved region Kelch_6 PF13964.6 ETO34285.1 - 1.4e-08 34.7 4.8 0.0037 17.5 0.6 4.0 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO34285.1 - 6.7e-07 28.8 1.3 5.8e-05 22.6 0.2 3.4 3 0 0 3 3 3 1 Kelch motif Kelch_5 PF13854.6 ETO34285.1 - 9.6e-07 28.7 2.6 0.11 12.5 1.0 4.4 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO34285.1 - 1.6e-06 27.8 2.7 0.0021 18.0 0.2 4.3 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO34285.1 - 2.7e-06 27.3 0.2 5.2e-05 23.2 0.1 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO34285.1 - 0.0072 16.6 0.1 0.065 13.6 0.0 2.7 4 0 0 4 4 4 1 Galactose oxidase, central domain GLE1 PF07817.13 ETO34286.1 - 0.38 9.9 5.9 0.29 10.3 2.5 2.2 2 1 0 2 2 2 0 GLE1-like protein WD40 PF00400.32 ETO34287.1 - 1e-116 377.5 44.9 3.4e-10 40.4 0.1 15.3 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34287.1 - 5.6e-20 71.4 13.1 0.2 12.0 0.1 10.2 1 1 8 9 9 9 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34287.1 - 9.7e-12 44.8 22.4 0.017 14.5 0.8 7.6 2 2 3 7 7 7 5 WD40-like domain NACHT PF05729.12 ETO34287.1 - 1.1e-08 35.2 0.0 2.2e-08 34.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Cytochrom_D1 PF02239.16 ETO34287.1 - 2.1e-06 26.5 3.0 0.17 10.4 0.0 5.2 5 1 1 6 6 6 2 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETO34287.1 - 5.5e-06 26.5 0.6 1.8e-05 24.8 0.6 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide PF00805.22 ETO34287.1 - 6.4e-06 25.7 3.6 2e-05 24.1 3.6 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO34287.1 - 1.3e-05 25.2 0.1 3.2 7.9 0.0 6.2 6 2 1 7 7 7 1 Strictosidine synthase AAA_22 PF13401.6 ETO34287.1 - 0.0002 21.6 0.0 0.00064 20.0 0.0 1.9 1 0 0 1 1 1 1 AAA domain PD40 PF07676.12 ETO34287.1 - 0.00042 20.2 7.6 51 4.0 0.0 7.8 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO34287.1 - 0.00057 20.0 0.5 4.3 7.4 0.0 5.2 4 3 1 5 5 5 1 Family of unknown function (DUF5570) HARP PF07443.13 ETO34287.1 - 0.0011 18.6 1.9 17 5.1 0.0 5.9 6 0 0 6 6 6 0 HepA-related protein (HARP) Pentapeptide_3 PF13576.6 ETO34287.1 - 0.0013 18.8 0.1 0.0036 17.4 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO34287.1 - 0.0021 18.6 0.9 0.039 14.5 0.0 3.0 2 0 0 2 2 2 1 AAA domain bPH_4 PF06713.11 ETO34287.1 - 0.012 15.6 0.3 0.14 12.3 0.3 3.0 1 0 0 1 1 1 0 Bacterial PH domain ATP_bind_2 PF03668.15 ETO34287.1 - 0.039 13.3 0.0 0.071 12.4 0.0 1.4 1 0 0 1 1 1 0 P-loop ATPase protein family AAA PF00004.29 ETO34287.1 - 0.044 14.2 0.2 1.1 9.7 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) RNA_helicase PF00910.22 ETO34287.1 - 0.21 12.0 3.5 0.63 10.5 0.1 3.6 3 1 0 3 3 2 0 RNA helicase Flavokinase PF01687.17 ETO34288.1 - 2e-26 92.4 0.0 1.2e-25 89.9 0.0 1.9 1 1 0 1 1 1 1 Riboflavin kinase zf-RING_5 PF14634.6 ETO34289.1 - 0.0065 16.4 14.9 0.011 15.7 14.9 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-RING_2 PF13639.6 ETO34289.1 - 0.034 14.5 14.4 0.058 13.7 14.4 1.4 1 0 0 1 1 1 0 Ring finger domain zf-C3HC4 PF00097.25 ETO34289.1 - 0.035 14.0 15.4 0.061 13.2 15.4 1.4 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) DUF3496 PF12001.8 ETO34289.1 - 0.09 13.2 1.9 0.27 11.6 1.9 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3496) Cep57_CLD_2 PF14197.6 ETO34289.1 - 0.12 12.4 2.4 0.33 11.1 1.4 2.1 2 0 0 2 2 2 0 Centrosome localisation domain of PPC89 Zn_ribbon_17 PF17120.5 ETO34289.1 - 0.13 11.9 10.2 0.22 11.2 10.2 1.3 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type Prok-RING_4 PF14447.6 ETO34289.1 - 0.77 9.7 12.4 1.6 8.7 12.4 1.5 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 AnmK PF03702.14 ETO34290.1 - 5e-48 164.0 0.0 1.7e-31 109.7 0.0 2.1 2 0 0 2 2 2 2 Anhydro-N-acetylmuramic acid kinase NOG1_N PF17835.1 ETO34290.1 - 0.058 13.4 0.7 0.12 12.3 0.7 1.5 1 0 0 1 1 1 0 NOG1 N-terminal helical domain DUF4349 PF14257.6 ETO34290.1 - 0.087 12.3 0.4 0.14 11.6 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4349) Arf PF00025.21 ETO34291.1 - 4.3e-55 185.8 0.1 4.8e-55 185.7 0.1 1.0 1 0 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ETO34291.1 - 6.7e-11 42.0 0.0 7.4e-11 41.9 0.0 1.0 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO34291.1 - 7e-08 32.7 0.0 1e-07 32.2 0.0 1.2 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase G-alpha PF00503.20 ETO34291.1 - 3.1e-07 29.9 0.1 4.6e-07 29.3 0.1 1.3 1 1 0 1 1 1 1 G-protein alpha subunit Gtr1_RagA PF04670.12 ETO34291.1 - 8.8e-06 25.2 0.0 1.1e-05 24.9 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO34291.1 - 0.00011 21.8 0.0 0.00013 21.5 0.0 1.1 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain SRPRB PF09439.10 ETO34291.1 - 0.00013 21.5 0.0 0.00015 21.3 0.0 1.1 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit MMR_HSR1 PF01926.23 ETO34291.1 - 0.031 14.3 0.0 0.049 13.7 0.0 1.3 1 0 0 1 1 1 0 50S ribosome-binding GTPase PRKG1_interact PF15898.5 ETO34293.1 - 0.0093 16.9 4.3 0.0093 16.9 4.3 3.5 3 0 0 3 3 3 2 cGMP-dependent protein kinase interacting domain TruB_C_2 PF16198.5 ETO34293.1 - 0.33 11.1 2.1 0.81 9.9 0.1 2.7 2 1 0 2 2 2 0 tRNA pseudouridylate synthase B C-terminal domain TSC22 PF01166.18 ETO34293.1 - 7 7.1 23.0 5 7.5 0.1 5.3 4 2 1 5 5 5 0 TSC-22/dip/bun family C2-C2_1 PF11618.8 ETO34294.1 - 0.0022 18.1 0.0 0.0047 17.0 0.0 1.6 1 0 0 1 1 1 1 First C2 domain of RPGR-interacting protein 1 CPBP PF02517.16 ETO34295.1 - 6.2e-16 58.5 1.9 6.2e-16 58.5 1.9 2.5 2 1 0 2 2 2 1 CPBP intramembrane metalloprotease DUF543 PF04418.12 ETO34295.1 - 0.1 12.6 0.1 0.46 10.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF543) SSrecog PF03531.14 ETO34299.1 - 0.19 11.7 2.2 0.62 10.0 0.8 2.3 2 0 0 2 2 2 0 Structure-specific recognition protein (SSRP1) EcsC PF12787.7 ETO34299.1 - 0.25 11.0 1.5 0.35 10.5 0.4 1.6 1 1 0 1 1 1 0 EcsC protein family Peptidase_S49_N PF08496.10 ETO34299.1 - 0.37 10.8 2.4 0.61 10.1 2.4 1.3 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PPR_3 PF13812.6 ETO34300.1 - 1.8e-13 50.4 1.3 1.3e-05 25.2 0.0 3.6 2 2 1 3 3 3 3 Pentatricopeptide repeat domain PPR PF01535.20 ETO34300.1 - 1.9e-11 43.4 0.4 7.8e-06 25.8 0.1 2.8 3 0 0 3 3 3 2 PPR repeat PPR_2 PF13041.6 ETO34300.1 - 2.4e-11 43.7 1.0 2.3e-09 37.3 0.3 2.9 2 1 1 3 3 3 2 PPR repeat family PPR_1 PF12854.7 ETO34300.1 - 7.6e-10 38.3 0.3 3.1e-05 23.6 0.0 2.8 3 0 0 3 3 3 2 PPR repeat ATP13 PF12921.7 ETO34300.1 - 0.00083 19.2 0.4 0.0019 18.0 0.4 1.6 1 1 0 1 1 1 1 Mitochondrial ATPase expression PPR_long PF17177.4 ETO34300.1 - 0.019 14.4 0.0 0.031 13.6 0.0 1.4 1 0 0 1 1 1 0 Pentacotripeptide-repeat region of PRORP WD40 PF00400.32 ETO34301.1 - 1.9e-05 25.3 5.7 0.00014 22.6 0.6 3.5 3 1 1 4 4 4 1 WD domain, G-beta repeat DUF4221 PF13970.6 ETO34301.1 - 0.0012 18.5 0.6 0.0015 18.2 0.6 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) WD40 PF00400.32 ETO34302.1 - 9.8e-23 80.0 9.9 5.5e-08 33.3 0.6 3.7 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO34302.1 - 8.3e-05 21.4 0.3 1.2 7.7 0.0 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34302.1 - 0.00056 20.2 0.0 0.32 11.3 0.0 2.6 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain PRANC PF09372.10 ETO34303.1 - 0.018 15.3 4.0 0.018 15.3 4.0 2.0 2 1 1 3 3 3 0 PRANC domain Pentapeptide PF00805.22 ETO34305.1 - 0.001 18.6 0.5 0.016 14.8 0.1 2.5 2 0 0 2 2 2 1 Pentapeptide repeats (8 copies) LRR_4 PF12799.7 ETO34305.1 - 0.01 16.2 5.4 0.42 11.1 0.3 3.6 2 1 1 3 3 3 0 Leucine Rich repeats (2 copies) LRR_6 PF13516.6 ETO34305.1 - 0.026 14.6 2.1 33 4.9 0.1 4.2 4 0 0 4 4 4 0 Leucine Rich repeat PUB PF09409.10 ETO34306.1 - 4.3e-08 33.0 0.0 3e-07 30.3 0.0 2.2 2 0 0 2 2 2 1 PUB domain UCH PF00443.29 ETO34308.1 - 7e-11 42.1 4.0 1.4e-09 37.9 2.0 2.8 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO34308.1 - 0.0092 15.6 2.3 0.019 14.6 0.1 2.2 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PHtD_u1 PF16645.5 ETO34308.1 - 2.1 8.9 4.7 25 5.4 2.8 2.4 2 0 0 2 2 2 0 Unstructured region on Pneumococcal histidine triad protein Rad17 PF03215.15 ETO34309.1 - 0.014 15.4 0.6 0.036 14.0 0.6 1.8 1 0 0 1 1 1 0 Rad17 P-loop domain FliL PF03748.14 ETO34310.1 - 0.054 14.1 0.3 0.25 11.9 0.3 2.1 1 1 0 1 1 1 0 Flagellar basal body-associated protein FliL Fungal_KA1 PF16797.5 ETO34310.1 - 0.054 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Fungal kinase associated-1 domain WD40 PF00400.32 ETO34311.1 - 8.8e-128 412.5 52.7 4.2e-09 36.9 0.0 16.5 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34311.1 - 1e-28 99.4 16.4 0.0062 16.8 0.0 12.1 2 2 11 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34311.1 - 1.8e-21 76.5 2.1 0.44 9.4 0.0 11.7 3 3 9 13 13 13 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34311.1 - 1.6e-14 54.0 7.1 0.00051 19.5 0.0 7.6 3 2 3 8 8 8 5 WD40-like domain Nup160 PF11715.8 ETO34311.1 - 3.4e-10 39.2 29.1 0.8 8.3 0.1 12.5 2 2 7 12 12 12 4 Nucleoporin Nup120/160 NACHT PF05729.12 ETO34311.1 - 1.2e-08 35.0 0.0 2.4e-08 34.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO34311.1 - 3.6e-07 29.7 2.8 7.5e-07 28.7 2.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO34311.1 - 0.00018 21.3 12.4 41 4.3 0.1 7.8 7 0 0 7 7 7 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO34311.1 - 0.00097 17.8 5.3 3.4 6.1 0.1 5.4 3 2 3 6 6 6 1 Cytochrome D1 heme domain AAA_22 PF13401.6 ETO34311.1 - 0.0013 19.0 0.0 0.0038 17.5 0.0 1.8 1 0 0 1 1 1 1 AAA domain Pentapeptide_4 PF13599.6 ETO34311.1 - 0.0044 17.2 0.7 0.017 15.3 0.7 2.0 1 1 0 1 1 1 1 Pentapeptide repeats (9 copies) Gmad1 PF10647.9 ETO34311.1 - 0.013 15.2 1.5 2.5 7.8 0.1 3.7 4 1 0 4 4 4 0 Lipoprotein LpqB beta-propeller domain AAA_18 PF13238.6 ETO34311.1 - 0.014 16.0 0.0 0.063 13.8 0.0 2.2 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ETO34311.1 - 0.015 15.7 0.0 0.34 11.3 0.0 2.5 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) DUF5570 PF17731.1 ETO34311.1 - 0.068 13.3 13.4 27 4.9 2.0 7.2 4 2 1 5 5 5 0 Family of unknown function (DUF5570) Pentapeptide_3 PF13576.6 ETO34311.1 - 0.081 13.1 0.0 0.18 12.0 0.0 1.5 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) BLUF PF04940.12 ETO34311.1 - 0.1 12.7 2.4 19 5.5 0.0 5.5 7 0 0 7 7 6 0 Sensors of blue-light using FAD RNA_helicase PF00910.22 ETO34311.1 - 0.51 10.7 4.7 1.7 9.1 0.1 3.8 3 1 0 3 3 3 0 RNA helicase Surfac_D-trimer PF09006.11 ETO34311.1 - 2.4 8.1 3.9 42 4.1 0.2 3.9 3 0 0 3 3 2 0 Lung surfactant protein D coiled-coil trimerisation DUF4718 PF15842.5 ETO34312.1 - 0.3 10.9 2.1 0.38 10.5 2.1 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4718) WD40 PF00400.32 ETO34313.1 - 1.8e-32 110.9 37.9 1.7e-06 28.6 0.4 7.9 8 1 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34313.1 - 7.2e-12 45.5 2.9 0.032 14.5 0.0 6.3 4 2 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34313.1 - 1e-09 37.6 7.4 0.001 17.9 0.1 5.5 3 2 2 5 5 5 4 Nucleoporin Nup120/160 TPR_12 PF13424.6 ETO34317.1 - 1.8e-60 201.1 8.7 1.4e-13 50.9 0.2 6.6 2 1 3 7 7 7 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34317.1 - 1.5e-38 129.1 39.7 3.1e-05 23.6 0.2 10.3 10 0 0 10 10 10 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO34317.1 - 9.9e-38 127.0 0.1 7.7e-05 22.4 0.1 9.2 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34317.1 - 8.7e-36 119.3 8.2 0.0011 18.8 0.0 9.4 9 0 0 9 9 9 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34317.1 - 1.8e-30 102.6 31.9 9.5e-05 22.2 0.2 10.3 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34317.1 - 2e-27 93.0 40.6 8.6e-06 25.6 0.8 9.7 9 0 0 9 9 9 7 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO34317.1 - 2.1e-14 54.1 0.9 4.8e-14 52.9 0.9 1.5 1 0 0 1 1 1 1 Caspase domain TPR_MalT PF17874.1 ETO34317.1 - 9.1e-14 51.6 0.0 1.2e-07 31.4 0.0 2.8 3 1 0 3 3 3 2 MalT-like TPR region TPR_17 PF13431.6 ETO34317.1 - 3.6e-13 48.9 7.8 0.51 10.8 0.1 8.9 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO34317.1 - 1.5e-12 48.0 0.0 1.6 9.4 0.0 7.4 6 1 1 7 7 7 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO34317.1 - 1.6e-09 37.8 0.0 3.2 8.8 0.0 7.3 8 0 0 8 8 6 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO34317.1 - 8.7e-08 31.7 22.7 1.3 8.8 0.0 8.6 8 1 1 9 9 9 4 TPR repeat TPR_6 PF13174.6 ETO34317.1 - 1.4e-07 31.7 4.2 17 6.3 0.0 7.3 7 0 0 7 7 6 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO34317.1 - 2.4e-06 28.0 3.7 0.92 10.1 0.0 5.6 5 1 1 6 6 6 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO34317.1 - 7.8e-06 25.8 10.6 2.1 8.1 0.2 6.9 6 1 2 8 8 8 1 Domain of unknown function (DUF5113) TPR_21 PF09976.9 ETO34317.1 - 0.00066 19.4 2.2 0.64 9.7 0.0 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat-like domain TPR_3 PF07720.12 ETO34317.1 - 0.0057 16.6 7.1 5.8 7.0 0.1 5.1 4 0 0 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO34317.1 - 0.011 15.1 0.2 0.011 15.1 0.2 4.6 6 0 0 6 6 5 0 SHNi-TPR ANAPC3 PF12895.7 ETO34317.1 - 0.038 14.2 15.8 5.6 7.3 3.6 5.7 4 1 2 6 6 6 0 Anaphase-promoting complex, cyclosome, subunit 3 Ten1_2 PF15490.6 ETO34317.1 - 0.039 13.7 0.0 28 4.5 0.0 3.5 3 0 0 3 3 3 0 Telomere-capping, CST complex subunit OrfA PF17495.2 ETO34317.1 - 0.098 12.8 0.7 55 4.0 0.0 4.4 2 2 3 5 5 5 0 Vpr-like OrfA MIT PF04212.18 ETO34317.1 - 0.11 12.5 22.0 1.8 8.7 0.6 7.0 6 1 1 7 7 7 0 MIT (microtubule interacting and transport) domain DUF627 PF04781.12 ETO34317.1 - 0.36 10.9 8.3 3.9 7.5 1.9 4.6 3 1 2 5 5 4 0 Protein of unknown function (DUF627) HEPN PF05168.14 ETO34317.1 - 2.9 8.0 7.0 29 4.8 0.0 4.1 4 0 0 4 4 4 0 HEPN domain RPN7 PF10602.9 ETO34317.1 - 4 7.1 17.8 14 5.3 0.9 5.5 2 1 2 5 5 5 0 26S proteasome subunit RPN7 Claudin_2 PF13903.6 ETO34318.1 - 0.0049 16.7 1.2 0.0065 16.2 1.2 1.2 1 0 0 1 1 1 1 PMP-22/EMP/MP20/Claudin tight junction Phage_NinH PF06322.11 ETO34318.1 - 0.0051 16.7 0.1 0.0088 15.9 0.1 1.4 1 0 0 1 1 1 1 Phage NinH protein Sarcoglycan_2 PF05510.13 ETO34320.1 - 0.013 14.3 0.2 0.021 13.6 0.2 1.2 1 0 0 1 1 1 0 Sarcoglycan alpha/epsilon Acp26Ab PF05777.12 ETO34320.1 - 0.037 14.7 0.4 0.12 13.0 0.4 1.8 1 0 0 1 1 1 0 Drosophila accessory gland-specific peptide 26Ab (Acp26Ab) DUF1899 PF08953.11 ETO34321.1 - 4.1e-13 49.0 0.1 7.8e-13 48.1 0.1 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF1899) WD40 PF00400.32 ETO34321.1 - 1.7e-11 44.4 0.2 7.7e-06 26.5 0.0 3.4 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34321.1 - 0.00036 20.8 0.0 0.24 11.7 0.0 2.5 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Crystall_2 PF09076.10 ETO34321.1 - 0.00069 19.5 0.2 0.58 10.1 0.0 2.4 2 0 0 2 2 2 2 Beta/Gamma crystallin TGBp3 PF02495.17 ETO34321.1 - 0.046 13.4 0.1 0.1 12.3 0.1 1.5 1 0 0 1 1 1 0 Triple gene block 3 Ank_2 PF12796.7 ETO34322.1 - 0.15 12.6 0.0 0.87 10.2 0.0 2.0 2 0 0 2 2 2 0 Ankyrin repeats (3 copies) Tubulin PF00091.25 ETO34326.1 - 4.5e-54 183.6 0.5 9.6e-54 182.6 0.5 1.5 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO34326.1 - 3.9e-16 59.3 0.2 6.8e-16 58.6 0.2 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Misat_Tub_SegII PF10644.9 ETO34326.1 - 2.7e-06 27.7 0.1 5.1e-06 26.8 0.1 1.5 1 0 0 1 1 1 1 Misato Segment II tubulin-like domain Tubulin_2 PF13809.6 ETO34326.1 - 0.014 14.6 0.0 0.026 13.7 0.0 1.4 1 0 0 1 1 1 0 Tubulin like Dna2 PF08696.11 ETO34327.1 - 1.3e-16 61.0 2.7 5.4e-16 59.0 0.1 2.4 1 1 1 2 2 2 1 DNA replication factor Dna2 WD40 PF00400.32 ETO34328.1 - 1e-43 146.4 24.9 6.3e-07 30.0 1.5 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO34328.1 - 5e-14 51.9 8.4 0.0014 17.4 0.3 5.9 1 1 4 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34328.1 - 2.3e-13 50.3 1.8 0.0083 16.4 0.0 5.9 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO34328.1 - 8.1e-07 28.1 9.7 8.8e-05 21.4 1.3 4.1 1 1 2 3 3 3 2 Nup133 N terminal like SAM_1 PF00536.30 ETO34330.1 - 1.2e-12 48.1 0.2 1.5e-12 47.8 0.2 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO34330.1 - 9.4e-12 44.9 0.1 1.2e-11 44.6 0.1 1.1 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) YlbE PF14003.6 ETO34330.1 - 0.00059 20.2 1.9 0.19 12.2 0.7 2.4 2 0 0 2 2 2 2 YlbE-like protein SAM_PNT PF02198.16 ETO34330.1 - 0.0032 17.4 1.1 0.0067 16.4 1.1 1.7 1 1 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_KSR1 PF13543.6 ETO34330.1 - 0.028 14.6 0.3 0.034 14.3 0.3 1.1 1 0 0 1 1 1 0 SAM like domain present in kinase suppressor RAS 1 DUF3964 PF13107.6 ETO34330.1 - 0.04 14.3 0.1 0.052 14.0 0.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3964) DUF3012 PF11216.8 ETO34330.1 - 1.1 9.4 4.0 7.2 6.7 0.2 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3012) SAM_1 PF00536.30 ETO34331.1 - 9.1e-06 26.0 0.4 2.7e-05 24.5 0.4 1.9 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO34331.1 - 0.045 13.9 0.0 0.13 12.4 0.0 1.7 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) CorA PF01544.18 ETO34331.1 - 0.17 11.2 6.1 0.066 12.5 0.7 2.2 2 0 0 2 2 2 0 CorA-like Mg2+ transporter protein DUF2785 PF10978.8 ETO34331.1 - 0.9 9.3 5.1 0.14 11.9 0.4 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2785) WD40 PF00400.32 ETO34333.1 - 6.7e-23 80.5 10.7 6.3e-07 30.0 0.1 4.7 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO34333.1 - 7.4e-06 24.9 0.8 0.037 12.7 0.0 2.9 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34333.1 - 1.5e-05 24.5 0.2 0.015 14.7 0.1 2.4 2 1 0 2 2 2 2 WD40-like domain ANAPC4_WD40 PF12894.7 ETO34333.1 - 2.1e-05 24.8 0.1 0.1 12.9 0.0 2.7 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4979 PF16351.5 ETO34333.1 - 0.066 13.4 4.7 7.6 6.7 0.3 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF4979) Kinesin PF00225.23 ETO34334.1 - 3.5e-17 62.4 0.1 3.5e-17 62.4 0.1 3.2 2 1 0 2 2 2 1 Kinesin motor domain TPR_12 PF13424.6 ETO34335.1 - 1.3e-91 300.9 12.8 1.1e-16 60.8 0.0 8.2 6 2 2 8 8 8 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO34335.1 - 3.4e-64 211.1 9.5 2.3e-06 27.3 0.0 13.9 13 1 1 14 14 14 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34335.1 - 1.6e-63 208.1 81.6 1.6e-08 34.0 0.8 14.6 14 1 0 14 14 14 12 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34335.1 - 5.9e-58 188.3 78.2 4.2e-07 29.7 0.7 14.4 14 0 0 14 14 14 12 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34335.1 - 2.9e-57 186.6 28.1 8.2e-09 34.9 0.1 13.4 12 1 1 13 13 13 11 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34335.1 - 3.5e-49 161.0 57.4 2.4e-06 27.2 0.2 14.3 14 0 0 14 14 14 12 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34335.1 - 3.3e-21 74.1 27.7 0.001 19.3 0.7 12.9 14 1 0 14 14 12 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO34335.1 - 1.2e-16 59.9 0.1 10 7.3 0.0 12.5 12 2 2 14 14 14 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO34335.1 - 8.1e-15 54.2 55.5 9.9e-06 25.1 0.4 13.2 14 2 2 16 16 15 5 TPR repeat TPR_6 PF13174.6 ETO34335.1 - 3.9e-14 52.3 12.6 1.5 9.6 0.1 10.8 13 0 0 13 13 9 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO34335.1 - 6e-14 52.4 0.0 0.79 10.4 0.0 8.6 8 3 2 10 10 9 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO34335.1 - 9.8e-13 48.2 0.0 0.0002 20.9 0.0 3.5 2 1 1 3 3 3 3 MalT-like TPR region SNAP PF14938.6 ETO34335.1 - 2.7e-12 46.7 16.7 8.7e-06 25.4 0.2 5.0 2 1 2 5 5 5 3 Soluble NSF attachment protein, SNAP DUF5113 PF17140.4 ETO34335.1 - 3.8e-10 39.8 33.1 2.6 7.8 0.0 10.6 9 2 2 11 11 11 5 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO34335.1 - 2.9e-05 24.5 2.3 1.3 9.6 0.0 6.6 5 3 2 7 7 7 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO34335.1 - 0.00023 20.6 14.5 0.71 9.4 0.0 8.0 8 0 0 8 8 8 1 SHNi-TPR ANAPC3 PF12895.7 ETO34335.1 - 0.00082 19.6 19.5 0.21 11.8 0.3 7.6 5 2 3 8 8 8 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF5475 PF17569.2 ETO34335.1 - 0.004 17.4 0.2 2.4 8.5 0.0 4.0 2 2 2 4 4 4 1 Family of unknown function (DUF5475) PPR PF01535.20 ETO34335.1 - 0.012 15.8 0.2 0.012 15.8 0.2 7.6 8 0 0 8 8 6 0 PPR repeat pPIWI_RE_REase PF18154.1 ETO34335.1 - 0.015 15.2 0.2 41 4.2 0.0 4.3 4 0 0 4 4 4 0 REase associating with pPIWI_RE POR PF01558.18 ETO34335.1 - 0.082 13.0 0.9 16 5.5 0.1 3.6 2 1 1 3 3 3 0 Pyruvate ferredoxin/flavodoxin oxidoreductase TPR_9 PF13371.6 ETO34335.1 - 0.087 13.0 0.1 49 4.2 0.0 3.9 3 1 0 3 3 3 0 Tetratricopeptide repeat DrsE PF02635.15 ETO34335.1 - 0.13 12.6 1.5 20 5.6 0.0 3.9 4 0 0 4 4 4 0 DsrE/DsrF-like family TPR_21 PF09976.9 ETO34335.1 - 0.24 11.1 6.1 3.2 7.4 0.0 4.5 5 1 0 6 6 4 0 Tetratricopeptide repeat-like domain Sel1 PF08238.12 ETO34335.1 - 0.33 11.7 27.9 6.5 7.6 0.1 9.4 9 1 1 10 10 10 0 Sel1 repeat MIT PF04212.18 ETO34335.1 - 0.56 10.3 42.8 3 8.0 1.5 9.3 9 1 2 11 11 9 0 MIT (microtubule interacting and transport) domain PPR_2 PF13041.6 ETO34335.1 - 0.6 10.4 8.3 2.2 8.5 0.1 4.3 3 0 0 3 3 3 0 PPR repeat family DUF4810 PF16068.5 ETO34335.1 - 1.4 9.5 13.7 11 6.6 0.1 6.5 5 4 3 8 8 7 0 Domain of unknown function (DUF4810) TPR_3 PF07720.12 ETO34335.1 - 2.6 8.2 28.3 0.58 10.2 0.5 7.2 7 0 0 7 7 7 0 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO34335.1 - 8.5 6.1 17.3 54 3.5 0.8 7.3 7 1 0 7 7 7 0 Helix-turn-helix bacterial domain WD40 PF00400.32 ETO34336.1 - 7.2e-40 134.3 25.2 1.4e-06 28.9 0.5 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34336.1 - 1e-12 48.2 6.1 0.029 14.7 0.0 6.0 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34336.1 - 2.4e-09 36.4 10.1 0.66 8.5 0.1 5.9 2 2 3 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34336.1 - 2.1e-07 30.6 7.0 0.0046 16.3 0.3 4.5 3 1 0 4 4 4 3 WD40-like domain TetM_leader PF08076.11 ETO34336.1 - 0.097 12.5 2.5 6.9 6.6 0.2 3.6 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide Peptidase_C14 PF00656.22 ETO34337.1 - 8.9e-09 35.7 0.3 4.6e-08 33.3 0.3 1.8 1 1 0 1 1 1 1 Caspase domain zf-TRAF PF02176.18 ETO34338.1 - 8.4e-06 26.4 3.2 8.4e-06 26.4 3.2 3.1 2 1 1 3 3 3 1 TRAF-type zinc finger GTP-bdg_N PF13167.6 ETO34338.1 - 0.03 15.0 0.4 7.1 7.4 0.0 2.7 3 0 0 3 3 3 0 GTP-binding GTPase N-terminal WD40 PF00400.32 ETO34340.1 - 7.5e-35 118.4 30.8 1.2e-06 29.1 0.2 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34340.1 - 2.4e-10 40.6 1.7 0.063 13.6 0.0 4.8 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34340.1 - 6.1e-10 38.4 8.2 0.18 10.4 0.3 5.1 3 2 2 5 5 5 5 Nucleoporin Nup120/160 Exo_endo_phos_2 PF14529.6 ETO34341.1 - 4.5e-11 42.6 0.3 1.8e-10 40.7 0.1 2.1 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase Exo_endo_phos PF03372.23 ETO34341.1 - 0.00079 19.0 0.0 0.0013 18.3 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family SMYLE_N PF18615.1 ETO34342.1 - 0.1 12.1 6.5 0.11 12.0 6.5 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF1770 PF08589.10 ETO34342.1 - 5.4 8.0 9.4 2.4 9.2 2.1 2.2 1 1 1 2 2 2 0 Fungal protein of unknown function (DUF1770) WD40 PF00400.32 ETO34343.1 - 3.1e-52 173.4 16.2 8.5e-10 39.1 0.2 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34343.1 - 3e-23 81.9 0.5 0.0029 17.9 0.0 7.1 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34343.1 - 7.5e-13 48.1 1.0 0.0045 16.0 0.0 6.2 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO34343.1 - 1.3e-06 27.4 0.2 0.15 10.6 0.0 3.8 2 2 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34343.1 - 4e-06 26.4 0.1 0.02 14.3 0.0 3.3 2 1 1 4 4 4 3 WD40-like domain Nbas_N PF15492.6 ETO34343.1 - 0.00018 21.0 0.3 0.08 12.3 0.1 3.2 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO34343.1 - 0.00025 19.7 0.0 0.022 13.3 0.0 2.6 1 1 2 3 3 3 1 Cytochrome D1 heme domain Coatomer_WDAD PF04053.14 ETO34343.1 - 0.00031 19.9 0.1 0.0049 16.0 0.1 2.4 1 1 1 2 2 2 1 Coatomer WD associated region DPPIV_N PF00930.21 ETO34343.1 - 0.0015 17.3 0.3 0.54 9.0 0.0 4.1 2 2 3 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO34343.1 - 0.0019 18.1 7.8 5.4 7.1 0.0 5.5 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat VID27 PF08553.10 ETO34343.1 - 0.0025 16.9 0.0 0.033 13.2 0.0 2.3 1 1 0 2 2 2 1 VID27 C-terminal WD40-like domain DUF2963 PF11178.8 ETO34343.1 - 0.0048 16.6 0.5 0.2 11.4 0.0 3.8 4 0 0 4 4 4 1 Protein of unknown function (DUF2963) DUF1854 PF08909.11 ETO34343.1 - 0.033 14.0 0.1 8.5 6.2 0.0 3.3 3 2 1 4 4 4 0 Domain of unknown function (DUF1854) PQQ_2 PF13360.6 ETO34343.1 - 0.064 12.8 0.0 0.83 9.2 0.0 2.4 1 1 0 1 1 1 0 PQQ-like domain SPDY PF03771.16 ETO34343.1 - 0.23 11.4 0.3 1.2 9.1 0.0 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF317) RVT_1 PF00078.27 ETO34344.1 - 2.1e-11 43.8 0.0 3.7e-11 43.0 0.0 1.4 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF5638 PF18688.1 ETO34344.1 - 0.09 13.1 4.3 0.15 12.4 4.3 1.5 1 0 0 1 1 1 0 Family of unknown function (DUF5638) EMC3_TMCO1 PF01956.16 ETO34344.1 - 0.22 11.3 0.9 0.44 10.3 0.9 1.5 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like ESCRT-II PF05871.12 ETO34347.1 - 0.039 14.2 1.2 0.54 10.5 0.4 2.4 2 0 0 2 2 2 0 ESCRT-II complex subunit TRIQK PF15168.6 ETO34347.1 - 0.065 13.1 0.2 0.17 11.8 0.2 1.6 1 0 0 1 1 1 0 Triple QxxK/R motif-containing protein family Mucin PF01456.17 ETO34347.1 - 1.6 8.7 12.0 3.4 7.7 12.0 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein NST1 PF13945.6 ETO34347.1 - 3.4 7.7 23.3 4.9 7.2 15.7 2.5 2 1 0 2 2 2 0 Salt tolerance down-regulator DUF600 PF04634.12 ETO34349.1 - 0.014 15.5 2.8 0.014 15.5 2.8 2.0 2 0 0 2 2 2 0 Protein of unknown function, DUF600 DUF402 PF04167.13 ETO34349.1 - 0.065 13.4 0.4 0.13 12.5 0.4 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF402) SurA_N_3 PF13624.6 ETO34349.1 - 1.3 8.8 11.1 0.61 9.9 7.9 2.0 1 1 1 2 2 2 0 SurA N-terminal domain DUF4337 PF14235.6 ETO34350.1 - 0.12 12.5 2.6 0.15 12.1 2.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) FAM76 PF16046.5 ETO34350.1 - 0.18 11.1 6.2 0.2 11.0 6.2 1.1 1 0 0 1 1 1 0 FAM76 protein CBS PF00571.28 ETO34351.1 - 8.7e-07 29.3 0.0 4.8e-05 23.7 0.0 2.3 2 0 0 2 2 2 1 CBS domain OTCace PF00185.24 ETO34351.1 - 0.00052 20.1 0.0 0.00073 19.7 0.0 1.2 1 0 0 1 1 1 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain zf-TRAF PF02176.18 ETO34352.1 - 1.2e-05 25.9 4.5 1.2e-05 25.9 4.5 2.6 1 1 0 1 1 1 1 TRAF-type zinc finger zf-RING-like PF08746.11 ETO34352.1 - 0.16 12.3 2.9 0.19 12.0 0.2 2.6 2 0 0 2 2 2 0 RING-like domain SlyX PF04102.12 ETO34352.1 - 0.37 11.4 7.3 0.59 10.8 0.1 2.6 2 0 0 2 2 2 0 SlyX WD40 PF00400.32 ETO34353.1 - 1.3e-26 92.3 16.3 3.6e-06 27.6 0.0 5.9 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34353.1 - 1.2e-10 41.5 0.2 0.0028 17.9 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO34353.1 - 0.00044 20.2 0.1 0.12 12.3 0.0 3.0 3 2 1 4 4 4 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO34353.1 - 0.0015 17.9 0.4 0.042 13.2 0.8 2.9 1 1 2 3 3 3 1 WD40-like domain Cytochrom_D1 PF02239.16 ETO34353.1 - 0.027 13.0 0.0 0.23 10.0 0.0 2.0 2 0 0 2 2 2 0 Cytochrome D1 heme domain GSDH PF07995.11 ETO34353.1 - 0.16 11.3 0.0 0.25 10.6 0.0 1.2 1 0 0 1 1 1 0 Glucose / Sorbosone dehydrogenase GST_C_3 PF14497.6 ETO34354.1 - 1.4e-13 50.9 1.0 4.1e-13 49.4 0.1 2.3 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain GST_N PF02798.20 ETO34354.1 - 8.6e-10 38.8 0.0 1.8e-09 37.8 0.0 1.6 1 0 0 1 1 1 1 Glutathione S-transferase, N-terminal domain GST_C PF00043.25 ETO34354.1 - 2.5e-06 27.6 1.0 4.8e-06 26.7 0.1 2.0 2 0 0 2 2 2 1 Glutathione S-transferase, C-terminal domain DUF5401 PF17380.2 ETO34354.1 - 0.019 13.1 7.1 0.027 12.6 7.1 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5401) EPL1 PF10513.9 ETO34355.1 - 0.048 14.1 9.7 0.082 13.3 9.7 1.3 1 0 0 1 1 1 0 Enhancer of polycomb-like Zip PF02535.22 ETO34355.1 - 0.083 12.1 3.8 0.12 11.6 3.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO34355.1 - 0.09 11.5 2.3 0.1 11.3 2.3 1.2 1 0 0 1 1 1 0 Presenilin DUF4820 PF16091.5 ETO34355.1 - 1.1 8.6 3.5 1.5 8.1 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) HCO3_cotransp PF00955.21 ETO34355.1 - 1.7 7.4 4.3 2.4 6.9 4.3 1.2 1 0 0 1 1 1 0 HCO3- transporter family NST1 PF13945.6 ETO34355.1 - 2.4 8.2 20.9 4 7.5 20.9 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Apc15p PF05841.11 ETO34355.1 - 5.6 7.8 15.9 10 6.9 15.9 1.5 1 0 0 1 1 1 0 Apc15p protein Menin PF05053.13 ETO34355.1 - 5.6 5.2 11.5 7.4 4.8 11.5 1.1 1 0 0 1 1 1 0 Menin DUF4834 PF16118.5 ETO34355.1 - 6.5 7.8 6.2 23 6.0 6.2 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) EVI2A PF05399.11 ETO34355.1 - 10 5.7 14.8 15 5.1 14.8 1.2 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) WD40 PF00400.32 ETO34356.1 - 4.3e-38 128.6 21.3 6.1e-07 30.0 0.9 7.6 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34356.1 - 2.3e-12 47.0 1.3 0.03 14.6 0.0 5.4 4 2 1 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34356.1 - 4.4e-06 25.6 4.9 0.35 9.5 0.5 4.4 2 2 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34356.1 - 6.9e-06 25.6 5.2 0.069 12.5 0.1 3.6 3 1 1 4 4 4 2 WD40-like domain DUF3931 PF13082.6 ETO34356.1 - 0.036 14.2 2.3 8.8 6.6 0.0 3.3 3 0 0 3 3 3 0 Protein of unknown function (DUF3931) DUF3391 PF11871.8 ETO34357.1 - 1.1 9.8 5.6 1.7 9.2 5.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3391) FAM176 PF14851.6 ETO34357.1 - 1.7 8.3 6.9 3 7.5 6.9 1.3 1 0 0 1 1 1 0 FAM176 family Pyr_redox_2 PF07992.14 ETO34358.1 - 0.00035 19.9 0.0 0.00058 19.2 0.0 1.3 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase RabGAP-TBC PF00566.18 ETO34359.1 - 6.6e-06 25.9 4.3 6.6e-06 25.9 4.3 3.4 3 1 0 3 3 3 1 Rab-GTPase-TBC domain Mucin PF01456.17 ETO34359.1 - 0.19 11.7 25.8 1 9.3 26.1 2.1 2 0 0 2 2 2 0 Mucin-like glycoprotein DUF3169 PF11368.8 ETO34359.1 - 0.41 10.1 0.0 0.41 10.1 0.0 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF3169) TRAP_alpha PF03896.16 ETO34359.1 - 0.5 9.5 10.0 1.1 8.4 10.0 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit SOG2 PF10428.9 ETO34359.1 - 0.65 9.1 17.6 0.93 8.6 17.6 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein SSP160 PF06933.11 ETO34359.1 - 1 7.4 19.4 1.5 6.9 19.4 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Utp14 PF04615.13 ETO34359.1 - 5.1 5.5 31.8 8.7 4.8 31.8 1.2 1 0 0 1 1 1 0 Utp14 protein TLD PF07534.16 ETO34360.1 - 1.2e-15 57.9 2.2 1.2e-15 57.9 2.2 2.0 3 0 0 3 3 3 1 TLD Rep_fac-A_C PF08646.10 ETO34361.1 - 6.6e-15 55.1 0.0 2.2e-14 53.4 0.0 1.8 2 0 0 2 2 2 1 Replication factor-A C terminal domain REPA_OB_2 PF16900.5 ETO34361.1 - 5.4e-12 45.5 0.0 1.4e-11 44.1 0.0 1.7 1 0 0 1 1 1 1 Replication protein A OB domain tRNA_anti-codon PF01336.25 ETO34361.1 - 0.05 13.6 0.0 0.19 11.7 0.0 2.0 2 1 0 2 2 2 0 OB-fold nucleic acid binding domain WD40 PF00400.32 ETO34362.1 - 1.8e-08 34.9 6.0 0.029 15.2 0.2 4.5 3 1 1 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34362.1 - 0.012 15.8 0.0 1.1 9.6 0.0 2.5 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain COX2_TM PF02790.15 ETO34362.1 - 1.5 9.0 6.8 4.5 7.5 1.7 2.7 2 1 1 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane domain DUF2116 PF09889.9 ETO34362.1 - 6.9 6.7 8.6 20 5.2 1.5 2.6 2 0 0 2 2 2 0 Uncharacterized protein containing a Zn-ribbon (DUF2116) AOC_like PF18678.1 ETO34364.1 - 0.19 11.3 0.0 0.24 11.0 0.0 1.2 1 0 0 1 1 1 0 Allene oxide cyclase barrel like domain Clathrin PF00637.20 ETO34365.1 - 1.5e-07 31.4 0.0 3.2e-05 23.8 0.1 2.6 2 0 0 2 2 2 2 Region in Clathrin and VPS 60KD_IMP PF02096.20 ETO34365.1 - 0.0054 16.7 0.3 0.01 15.8 0.3 1.5 1 0 0 1 1 1 1 60Kd inner membrane protein Rad60-SLD PF11976.8 ETO34367.1 - 0.00026 20.8 0.0 0.00066 19.5 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin-2 like Rad60 SUMO-like ubiquitin PF00240.23 ETO34367.1 - 0.0072 16.1 0.0 0.013 15.2 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin family MBT PF02820.18 ETO34368.1 - 0.00024 21.4 0.1 0.0016 18.8 0.0 2.1 2 0 0 2 2 2 1 mbt repeat Tudor-knot PF11717.8 ETO34368.1 - 0.072 13.0 0.7 0.19 11.6 0.7 1.7 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain PAP_assoc PF03828.19 ETO34369.1 - 6.6e-13 48.7 0.3 3.5e-12 46.4 0.3 2.4 1 0 0 1 1 1 1 Cid1 family poly A polymerase SRTM1 PF15872.5 ETO34369.1 - 0.022 14.9 0.0 0.096 12.8 0.0 2.0 2 0 0 2 2 2 0 Serine-rich and transmembrane domain-containing protein 1 Nrap_D2 PF17403.2 ETO34369.1 - 0.053 13.3 1.2 0.96 9.2 0.0 3.0 3 0 0 3 3 3 0 Nrap protein PAP/OAS-like domain Menin PF05053.13 ETO34369.1 - 9.6 4.4 10.6 14 3.8 10.6 1.2 1 0 0 1 1 1 0 Menin CNOT11 PF10155.9 ETO34370.1 - 4.3e-39 133.5 4.7 4.3e-39 133.5 4.7 1.5 2 0 0 2 2 2 1 CCR4-NOT transcription complex subunit 11 MAPKK1_Int PF08923.10 ETO34371.1 - 2.9e-16 59.4 1.0 3.7e-16 59.0 1.0 1.1 1 0 0 1 1 1 1 Mitogen-activated protein kinase kinase 1 interacting Phageshock_PspD PF09584.10 ETO34371.1 - 0.17 12.0 0.1 0.28 11.3 0.1 1.3 1 0 0 1 1 1 0 Phage shock protein PspD (Phageshock_PspD) ETRAMP PF09716.10 ETO34372.1 - 0.18 11.9 0.1 0.18 11.9 0.1 2.7 2 2 1 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) ESSS PF10183.9 ETO34372.1 - 0.4 10.9 1.9 0.49 10.6 0.2 2.0 2 0 0 2 2 2 0 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I) GET2 PF08690.10 ETO34372.1 - 3.6 7.2 5.0 34 4.0 4.5 2.2 1 1 0 1 1 1 0 GET complex subunit GET2 Orf78 PF06024.12 ETO34373.1 - 0.016 15.5 0.5 0.023 15.0 0.5 1.3 1 0 0 1 1 1 0 Orf78 (ac78) DHHC PF01529.20 ETO34375.1 - 2.4e-09 37.4 4.7 3.1e-09 37.1 4.7 1.1 1 0 0 1 1 1 1 DHHC palmitoyltransferase Glyco_transf_25 PF01755.17 ETO34376.1 - 0.0078 16.1 0.1 0.0084 16.0 0.1 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 25 (LPS biosynthesis protein) HLH PF00010.26 ETO34376.1 - 0.049 13.6 0.0 0.13 12.3 0.0 1.7 1 1 0 1 1 1 0 Helix-loop-helix DNA-binding domain Cytokin-bind PF09265.10 ETO34376.1 - 0.075 12.4 0.5 0.098 12.0 0.5 1.3 1 0 0 1 1 1 0 Cytokinin dehydrogenase 1, FAD and cytokinin binding MRP-L28 PF09812.9 ETO34377.1 - 0.012 15.7 0.2 0.025 14.7 0.0 1.6 2 0 0 2 2 2 0 Mitochondrial ribosomal protein L28 WD40 PF00400.32 ETO34378.1 - 7.4e-17 61.4 1.3 4.6e-09 36.7 0.2 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO34378.1 - 0.00015 20.9 0.0 0.16 10.9 0.0 2.6 2 1 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO34378.1 - 0.0076 16.5 0.0 0.05 13.9 0.0 2.2 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO34378.1 - 0.0082 16.1 0.1 9.6 6.3 0.1 3.3 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat DUF3291 PF11695.8 ETO34378.1 - 0.059 13.0 0.0 0.079 12.6 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF3291) DUF3261 PF11659.8 ETO34378.1 - 0.098 12.5 0.0 1.5 8.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3261) CCDC-167 PF15188.6 ETO34379.1 - 0.0016 18.7 6.8 0.0016 18.7 6.8 1.6 2 0 0 2 2 2 1 Coiled-coil domain-containing protein 167 NAP PF00956.18 ETO34379.1 - 0.032 13.4 4.9 0.041 13.0 4.9 1.2 1 0 0 1 1 1 0 Nucleosome assembly protein (NAP) CortBP2 PF09727.9 ETO34379.1 - 0.16 11.8 15.7 0.057 13.3 12.6 1.7 2 0 0 2 2 2 0 Cortactin-binding protein-2 Atg14 PF10186.9 ETO34379.1 - 0.24 10.5 12.5 0.37 9.8 12.5 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Seryl_tRNA_N PF02403.22 ETO34379.1 - 2.9 8.2 9.4 12 6.1 6.9 2.3 1 1 1 2 2 2 0 Seryl-tRNA synthetase N-terminal domain ZapB PF06005.12 ETO34379.1 - 9.6 6.7 21.6 2.3e+03 -0.9 0.2 3.1 2 1 0 2 2 2 0 Cell division protein ZapB DUF5359 PF17313.2 ETO34380.1 - 0.11 12.6 0.1 0.19 11.7 0.1 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5359) LRR_4 PF12799.7 ETO34381.1 - 0.018 15.5 4.3 2.6 8.6 0.1 4.4 4 1 1 5 5 5 0 Leucine Rich repeats (2 copies) DUF383 PF04063.14 ETO34381.1 - 0.062 13.0 0.6 0.099 12.3 0.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF383) LRR_1 PF00560.33 ETO34381.1 - 0.73 10.6 7.4 1.2e+02 3.9 0.1 5.3 4 1 0 4 4 4 0 Leucine Rich Repeat RT_RNaseH_2 PF17919.1 ETO34382.1 - 3.2e-18 65.6 1.6 4e-13 49.3 0.0 2.7 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase RT_RNaseH PF17917.1 ETO34382.1 - 1.5e-11 44.5 1.2 1.2e-07 31.9 0.5 2.6 1 1 1 2 2 2 2 RNase H-like domain found in reverse transcriptase SAP30_Sin3_bdg PF13867.6 ETO34382.1 - 0.019 15.3 0.1 0.066 13.6 0.1 1.9 1 0 0 1 1 1 0 Sin3 binding region of histone deacetylase complex subunit SAP30 DUF5343 PF17278.2 ETO34382.1 - 0.019 15.0 0.4 0.019 15.0 0.4 2.4 3 1 0 3 3 3 0 Family of unknown function (DUF5343) Integrase_H2C2 PF17921.1 ETO34382.1 - 0.026 14.6 0.2 0.054 13.6 0.2 1.6 1 0 0 1 1 1 0 Integrase zinc binding domain CAP_GLY PF01302.25 ETO34383.1 - 3.4e-16 59.0 0.3 6.6e-16 58.1 0.3 1.5 1 0 0 1 1 1 1 CAP-Gly domain DHDPS PF00701.22 ETO34384.1 - 2.6e-15 55.9 0.0 4.3e-15 55.2 0.0 1.3 1 1 0 1 1 1 1 Dihydrodipicolinate synthetase family D123 PF07065.14 ETO34385.1 - 0.0028 16.8 2.3 0.0041 16.3 2.3 1.2 1 0 0 1 1 1 1 D123 Neur_chan_memb PF02932.16 ETO34385.1 - 0.019 15.0 1.3 0.025 14.7 1.3 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region DUF2400 PF09674.10 ETO34385.1 - 0.043 13.8 1.0 0.061 13.3 1.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) Presenilin PF01080.17 ETO34385.1 - 0.046 12.5 4.8 0.06 12.1 4.8 1.1 1 0 0 1 1 1 0 Presenilin PIN_8 PF18476.1 ETO34385.1 - 0.16 11.8 6.3 0.22 11.4 6.3 1.2 1 0 0 1 1 1 0 PIN like domain DUF4175 PF13779.6 ETO34385.1 - 0.25 9.2 11.2 0.31 8.9 11.2 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Holin_BhlA PF10960.8 ETO34385.1 - 1.6 8.7 10.6 3.8 7.6 0.1 2.6 2 1 0 2 2 2 0 BhlA holin family BLM10_mid PF16507.5 ETO34386.1 - 7.5e-05 21.6 3.9 0.065 11.9 3.9 3.0 1 1 0 1 1 1 1 Proteasome-substrate-size regulator, mid region DUF3069 PF11269.8 ETO34386.1 - 0.12 12.6 0.4 0.19 12.0 0.4 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3069) HEAT_2 PF13646.6 ETO34387.1 - 0.00019 21.7 0.0 0.0024 18.2 0.0 2.4 2 1 0 2 2 2 1 HEAT repeats HEAT PF02985.22 ETO34387.1 - 0.00045 20.2 0.0 0.0072 16.5 0.0 2.9 3 0 0 3 3 3 1 HEAT repeat CLASP_N PF12348.8 ETO34387.1 - 0.00059 19.5 1.2 0.0016 18.1 0.4 1.9 2 0 0 2 2 2 1 CLASP N terminal DUF1758 PF05585.12 ETO34387.1 - 0.00083 19.2 0.2 0.0016 18.3 0.2 1.5 1 0 0 1 1 1 1 Putative peptidase (DUF1758) DNA_alkylation PF08713.11 ETO34387.1 - 0.0013 18.5 1.4 0.027 14.2 0.6 2.1 1 1 1 2 2 2 1 DNA alkylation repair enzyme HEAT_EZ PF13513.6 ETO34387.1 - 0.0016 18.9 0.0 1.4 9.5 0.0 3.3 2 1 2 4 4 4 1 HEAT-like repeat Cnd1 PF12717.7 ETO34387.1 - 0.0017 18.4 4.6 0.039 14.0 0.3 2.3 1 1 1 2 2 2 2 non-SMC mitotic condensation complex subunit 1 DUF3050 PF11251.8 ETO34387.1 - 0.0073 16.0 1.2 0.015 14.9 0.7 1.9 2 1 0 2 2 2 1 Protein of unknown function (DUF3050) Med23 PF11573.8 ETO34387.1 - 0.011 13.4 1.9 0.052 11.2 0.0 2.0 1 1 1 2 2 2 0 Mediator complex subunit 23 N_Asn_amidohyd PF14736.6 ETO34387.1 - 0.015 14.5 0.8 0.098 11.8 0.1 2.0 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase MA3 PF02847.17 ETO34387.1 - 0.043 13.8 2.3 0.28 11.2 0.3 2.5 1 1 1 2 2 2 0 MA3 domain RTP1_C1 PF10363.9 ETO34387.1 - 0.074 13.2 0.9 0.39 10.9 0.3 2.6 1 1 1 2 2 2 0 Required for nuclear transport of RNA pol II C-terminus 1 DUF445 PF04286.12 ETO34387.1 - 0.11 12.3 2.2 0.32 10.8 2.2 1.7 1 1 0 1 1 1 0 Protein of unknown function (DUF445) RNA_binding PF01877.17 ETO34387.1 - 0.11 12.8 5.5 0.11 12.7 1.6 2.7 2 1 1 3 3 3 0 RNA binding Vac14_Fig4_bd PF11916.8 ETO34387.1 - 0.15 11.7 1.4 0.2 11.3 0.4 1.8 2 1 0 2 2 2 0 Vacuolar protein 14 C-terminal Fig4p binding DUF4710 PF15828.5 ETO34387.1 - 0.25 11.5 2.0 2.8 8.1 0.0 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4710) CENP-F_leu_zip PF10473.9 ETO34389.1 - 0.00027 21.0 19.3 0.00027 21.0 19.3 5.6 2 1 1 4 4 4 2 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 GAS PF13851.6 ETO34389.1 - 0.00057 19.3 131.3 0.045 13.1 20.2 7.0 1 1 5 6 6 6 4 Growth-arrest specific micro-tubule binding CEP63 PF17045.5 ETO34389.1 - 0.0014 18.6 37.3 0.0014 18.6 37.3 4.8 1 1 1 3 3 2 1 Centrosomal protein of 63 kDa DUF948 PF06103.11 ETO34389.1 - 0.0023 18.2 54.6 0.071 13.4 0.9 7.5 4 2 4 8 8 8 5 Bacterial protein of unknown function (DUF948) Tropomyosin_1 PF12718.7 ETO34389.1 - 0.012 15.8 39.2 0.012 15.8 39.2 6.5 2 1 3 5 5 5 0 Tropomyosin like BLOC1_2 PF10046.9 ETO34389.1 - 0.016 15.5 10.2 0.016 15.5 10.2 8.8 3 3 5 8 8 8 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 TolA_bind_tri PF16331.5 ETO34389.1 - 0.021 14.9 2.7 0.021 14.9 2.7 9.7 4 3 5 9 9 9 0 TolA binding protein trimerisation AAA_13 PF13166.6 ETO34389.1 - 0.075 11.7 94.8 0.026 13.2 35.9 3.3 1 1 2 3 3 3 0 AAA domain Fez1 PF06818.15 ETO34389.1 - 0.55 10.7 111.2 0.31 11.5 22.8 4.9 1 1 3 4 4 4 0 Fez1 Spc7 PF08317.11 ETO34389.1 - 0.8 8.5 125.6 0.4 9.5 38.4 5.9 1 1 6 7 7 7 0 Spc7 kinetochore protein HMMR_N PF15905.5 ETO34389.1 - 2 7.8 133.3 1.4 8.4 37.3 5.4 1 1 3 4 4 4 0 Hyaluronan mediated motility receptor N-terminal DUF812 PF05667.11 ETO34389.1 - 4.2 6.1 121.0 1.4 7.7 23.1 4.4 1 1 2 4 4 4 0 Protein of unknown function (DUF812) Trans_reg_C PF00486.28 ETO34392.1 - 0.061 13.4 0.8 0.31 11.2 0.0 2.2 1 1 1 2 2 2 0 Transcriptional regulatory protein, C terminal Transcrip_reg PF01709.20 ETO34392.1 - 0.35 10.3 9.9 0.44 9.9 9.9 1.1 1 0 0 1 1 1 0 Transcriptional regulator Ribosomal_L37 PF08561.10 ETO34393.1 - 0.0011 19.5 0.3 0.0011 19.5 0.3 2.6 2 1 0 2 2 2 1 Mitochondrial ribosomal protein L37 Trypan_glycop PF00913.19 ETO34393.1 - 1.1 8.4 3.9 1.7 7.8 3.9 1.2 1 0 0 1 1 1 0 Trypanosome variant surface glycoprotein (A-type) Med7 PF05983.11 ETO34393.1 - 5 7.2 9.3 77 3.3 9.3 2.2 1 1 0 1 1 1 0 MED7 protein Ribosomal_S2 PF00318.20 ETO34394.1 - 4.1e-50 170.0 0.0 1.3e-49 168.4 0.0 1.8 1 1 0 1 1 1 1 Ribosomal protein S2 Dynamin_N PF00350.23 ETO34395.1 - 0.0022 18.1 0.9 0.0022 18.1 0.9 3.3 3 1 0 3 3 3 1 Dynamin family Rot1 PF10681.9 ETO34396.1 - 0.031 13.8 2.8 0.034 13.7 2.8 1.1 1 0 0 1 1 1 0 Chaperone for protein-folding within the ER, fungal Ntox1 PF15500.6 ETO34396.1 - 0.064 13.6 3.6 0.4 11.0 0.1 2.2 2 1 0 2 2 2 0 Putative RNase-like toxin, toxin_1 Acetyltransf_11 PF13720.6 ETO34396.1 - 1.4 9.4 4.4 1 9.8 1.5 2.0 2 0 0 2 2 2 0 Udp N-acetylglucosamine O-acyltransferase; Domain 2 Kelch_4 PF13418.6 ETO34397.1 - 8.1e-06 25.7 1.2 0.00015 21.7 0.1 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO34397.1 - 8.7e-05 22.7 5.6 0.0018 18.5 0.3 3.4 2 1 1 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO34397.1 - 0.0072 16.3 5.4 0.047 13.7 1.2 3.3 2 1 1 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO34397.1 - 0.077 12.6 2.2 3.2 7.4 0.1 3.1 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO34398.1 - 2.5e-33 113.6 6.7 2.2e-10 40.9 0.3 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34398.1 - 2.2e-11 43.9 0.1 0.0015 18.8 0.0 4.1 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34398.1 - 4.4e-08 32.5 0.1 0.12 11.3 0.0 4.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34398.1 - 1.4e-05 24.6 1.1 0.0052 16.2 0.1 2.8 2 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO34398.1 - 1.5e-05 23.8 0.2 0.052 12.2 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO34398.1 - 0.00017 20.3 0.0 0.0035 15.9 0.0 2.1 1 1 1 2 2 2 1 Cytochrome D1 heme domain SH3_12 PF18129.1 ETO34398.1 - 0.0018 18.3 0.1 0.0052 16.9 0.0 1.8 2 0 0 2 2 2 1 Xrn1 SH3-like domain PD40 PF07676.12 ETO34398.1 - 0.004 17.0 3.4 7.8 6.6 0.0 4.0 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO34398.1 - 0.038 14.1 0.0 0.26 11.4 0.0 2.2 2 1 1 3 3 3 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO34398.1 - 0.18 11.5 2.3 5.5 6.8 0.0 3.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature HSP70 PF00012.20 ETO34399.1 - 5.6e-218 725.0 6.3 7.7e-218 724.5 6.3 1.2 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO34399.1 - 1.3e-12 47.2 0.0 2e-12 46.6 0.0 1.2 1 0 0 1 1 1 1 MreB/Mbl protein MnmE_helical PF12631.7 ETO34399.1 - 0.0029 17.8 0.0 0.023 14.9 0.0 2.2 1 1 1 2 2 2 1 MnmE helical domain Hydantoinase_A PF01968.18 ETO34399.1 - 0.036 13.3 0.5 0.15 11.3 0.1 2.0 2 0 0 2 2 2 0 Hydantoinase/oxoprolinase NPV_P10 PF05531.12 ETO34399.1 - 0.88 10.1 6.0 1.1 9.8 0.2 3.2 3 0 0 3 3 3 0 Nucleopolyhedrovirus P10 protein NACHT PF05729.12 ETO34400.1 - 1.8e-16 60.5 0.0 4.2e-16 59.3 0.0 1.7 2 0 0 2 2 2 1 NACHT domain NB-ARC PF00931.22 ETO34400.1 - 0.00086 18.6 0.2 0.00086 18.6 0.2 2.6 3 0 0 3 3 3 1 NB-ARC domain AAA_22 PF13401.6 ETO34400.1 - 0.0039 17.5 0.6 0.12 12.6 0.1 2.9 2 1 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO34400.1 - 0.027 15.0 0.0 0.12 12.9 0.0 2.1 2 0 0 2 2 2 0 ABC transporter SMC_N PF02463.19 ETO34400.1 - 0.032 13.7 0.0 0.15 11.5 0.0 2.1 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain AAA_16 PF13191.6 ETO34400.1 - 0.071 13.5 0.0 0.16 12.3 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ETO34400.1 - 0.073 12.4 0.0 0.18 11.1 0.0 1.6 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_18 PF13238.6 ETO34400.1 - 0.074 13.6 0.0 0.074 13.6 0.0 3.0 2 2 2 4 4 4 0 AAA domain AAA_25 PF13481.6 ETO34400.1 - 0.085 12.4 0.0 0.36 10.4 0.0 2.2 1 1 0 1 1 1 0 AAA domain AAA_30 PF13604.6 ETO34400.1 - 0.091 12.5 0.0 0.17 11.6 0.0 1.4 1 0 0 1 1 1 0 AAA domain DUF87 PF01935.17 ETO34400.1 - 0.27 11.3 3.6 0.37 10.9 0.0 2.5 2 1 0 2 2 2 0 Helicase HerA, central domain HEAT PF02985.22 ETO34401.1 - 1.8e-19 68.1 3.0 2.8 8.5 0.1 11.4 12 0 0 12 12 12 5 HEAT repeat HEAT_2 PF13646.6 ETO34401.1 - 2.5e-12 47.0 0.0 0.00027 21.2 0.0 6.7 3 2 4 8 8 8 1 HEAT repeats HEAT_EZ PF13513.6 ETO34401.1 - 6.6e-11 42.5 0.0 0.38 11.3 0.0 8.2 8 3 2 10 10 9 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO34401.1 - 9.7e-07 29.3 7.4 0.044 14.4 0.2 5.0 3 1 1 4 4 4 2 Vacuolar 14 Fab1-binding region Cnd1 PF12717.7 ETO34401.1 - 1.2e-06 28.7 12.3 0.00017 21.7 1.1 4.5 3 1 1 4 4 4 2 non-SMC mitotic condensation complex subunit 1 Ank_3 PF13606.6 ETO34401.1 - 0.00029 21.0 0.1 0.036 14.6 0.0 3.8 3 0 0 3 3 3 1 Ankyrin repeat RTP1_C1 PF10363.9 ETO34401.1 - 0.0006 20.0 0.0 0.6 10.3 0.0 4.7 5 0 0 5 5 5 1 Required for nuclear transport of RNA pol II C-terminus 1 Ank_2 PF12796.7 ETO34401.1 - 0.00099 19.6 0.0 0.008 16.7 0.0 2.6 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) DUF4393 PF14337.6 ETO34401.1 - 0.0086 15.9 10.5 0.055 13.3 0.1 4.4 5 0 0 5 5 5 2 Domain of unknown function (DUF4393) Ank_5 PF13857.6 ETO34401.1 - 0.01 16.1 0.0 0.037 14.4 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeats (many copies) Ank PF00023.30 ETO34401.1 - 0.046 14.2 0.0 0.17 12.4 0.0 2.1 1 0 0 1 1 1 0 Ankyrin repeat Condensin2nSMC PF12422.8 ETO34401.1 - 0.3 11.2 2.5 6.5 6.9 0.1 4.1 3 1 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit HEAT_PBS PF03130.16 ETO34401.1 - 0.53 11.1 2.2 1.9e+02 3.2 0.0 5.5 6 0 0 6 6 6 0 PBS lyase HEAT-like repeat DUF1104 PF06518.11 ETO34402.1 - 0.00067 20.0 1.8 0.0066 16.8 0.0 2.6 2 1 0 2 2 2 1 Protein of unknown function (DUF1104) TetR_C_22 PF17928.1 ETO34402.1 - 0.028 14.7 1.0 10 6.5 0.1 3.0 2 1 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TetR_C_31 PF17940.1 ETO34402.1 - 0.036 14.3 0.1 0.088 13.0 0.1 1.6 1 0 0 1 1 1 0 Tetracyclin repressor-like, C-terminal domain TetR_C_15 PF17918.1 ETO34402.1 - 0.11 13.2 4.9 29 5.5 0.2 4.3 3 2 1 4 4 4 0 Tetracyclin repressor-like, C-terminal domain DUF370 PF04025.12 ETO34403.1 - 0.099 12.8 0.3 17 5.6 0.0 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF370) Myb_DNA-bind_6 PF13921.6 ETO34404.1 - 1.5e-09 37.9 0.8 3.6e-05 23.9 0.1 2.6 2 0 0 2 2 2 2 Myb-like DNA-binding domain Myb_DNA-binding PF00249.31 ETO34404.1 - 2.6e-06 27.5 0.2 0.00091 19.4 0.3 2.8 3 0 0 3 3 3 2 Myb-like DNA-binding domain zf-TRAF PF02176.18 ETO34405.1 - 6.9e-05 23.5 2.9 6.9e-05 23.5 2.9 2.9 2 1 0 2 2 2 1 TRAF-type zinc finger V-ATPase_G PF03179.15 ETO34405.1 - 0.07 13.7 8.6 0.11 13.0 7.4 2.1 1 1 0 1 1 1 0 Vacuolar (H+)-ATPase G subunit Exonuc_VII_L PF02601.15 ETO34405.1 - 0.17 11.4 5.2 0.2 11.2 5.2 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit Med26_C PF15693.5 ETO34405.1 - 0.4 10.8 11.9 0.099 12.8 7.5 1.9 2 0 0 2 2 2 0 Mediator complex subunit 26 C-terminal DUF4407 PF14362.6 ETO34405.1 - 0.59 9.4 4.0 0.9 8.8 4.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Gp58 PF07902.11 ETO34405.1 - 0.74 8.0 8.2 0.2 9.9 5.5 1.3 2 0 0 2 2 2 0 gp58-like protein WD40 PF00400.32 ETO34406.1 - 3.1e-10 40.5 6.7 0.00018 22.2 0.1 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat EBA-175_VI PF11556.8 ETO34407.1 - 0.016 15.5 1.2 0.023 15.0 1.2 1.3 1 0 0 1 1 1 0 Erythrocyte binding antigen 175 LPD28 PF18843.1 ETO34407.1 - 0.089 12.4 0.0 0.29 10.8 0.0 1.8 1 1 0 2 2 2 0 Large polyvalent protein associated domain 28 zf-C3HC4_2 PF13923.6 ETO34407.1 - 2.2 8.2 7.5 9.7 6.1 4.9 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) CAP_GLY PF01302.25 ETO34408.1 - 2.3e-09 37.1 0.0 3.8e-09 36.4 0.0 1.3 1 0 0 1 1 1 1 CAP-Gly domain YajC PF02699.15 ETO34408.1 - 0.093 12.6 1.0 0.19 11.6 0.0 1.9 2 0 0 2 2 2 0 Preprotein translocase subunit DUF247 PF03140.15 ETO34409.1 - 0.0069 15.6 0.8 0.01 15.1 0.8 1.2 1 0 0 1 1 1 1 Plant protein of unknown function WD40 PF00400.32 ETO34410.1 - 8.4e-07 29.6 1.0 0.0081 17.0 0.2 2.2 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40_like PF17005.5 ETO34410.1 - 0.024 13.9 0.2 0.086 12.2 0.2 1.8 1 1 0 1 1 1 0 WD40-like domain ANAPC4_WD40 PF12894.7 ETO34410.1 - 0.028 14.7 0.0 0.22 11.8 0.0 1.9 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Rota_VP4_MID PF17477.2 ETO34410.1 - 0.099 12.0 0.0 0.1 12.0 0.0 1.1 1 0 0 1 1 1 0 Rotavirus VP4 membrane interaction domain CSD PF00313.22 ETO34411.1 - 0.00029 20.6 0.8 0.63 9.9 0.0 3.0 2 1 0 2 2 2 2 'Cold-shock' DNA-binding domain CCDC106 PF15794.5 ETO34412.1 - 0.0036 17.1 8.0 0.0036 17.1 8.0 3.1 3 2 2 5 5 5 1 Coiled-coil domain-containing protein 106 DivIC PF04977.15 ETO34412.1 - 0.015 15.1 4.5 0.015 15.1 4.5 3.4 2 2 1 3 3 3 0 Septum formation initiator DUF3972 PF13118.6 ETO34412.1 - 0.98 9.9 16.6 0.05 14.0 7.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3972) zf-C3HC4_3 PF13920.6 ETO34413.1 - 1e-11 44.5 12.5 1.6e-11 43.9 12.5 1.3 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO34413.1 - 3.5e-05 23.6 12.6 6.5e-05 22.7 12.6 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO34413.1 - 0.0043 17.4 15.1 0.0087 16.4 15.1 1.6 1 0 0 1 1 1 1 Ring finger domain zf-RING_5 PF14634.6 ETO34413.1 - 0.031 14.2 14.1 0.056 13.4 14.1 1.5 1 0 0 1 1 1 0 zinc-RING finger domain zf-C3HC4 PF00097.25 ETO34413.1 - 0.16 11.8 16.7 0.35 10.8 16.7 1.6 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) WD40 PF00400.32 ETO34414.1 - 9.7e-08 32.6 4.3 2.6e-05 24.9 0.4 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO34414.1 - 0.0014 17.4 0.1 0.0016 17.2 0.1 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34414.1 - 0.0029 17.9 0.2 0.0082 16.4 0.1 1.7 1 1 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO34415.1 - 6.4e-102 330.6 49.5 1.4e-08 35.2 0.1 16.7 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34415.1 - 4e-27 94.3 16.5 0.03 14.6 0.0 13.7 3 2 11 14 14 14 9 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO34415.1 - 4.4e-09 36.5 0.0 8.9e-09 35.5 0.0 1.6 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO34415.1 - 2.7e-06 26.9 3.2 5.7e-06 25.9 3.2 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) AAA_22 PF13401.6 ETO34415.1 - 0.0016 18.7 0.0 0.0068 16.7 0.0 2.1 1 0 0 1 1 1 1 AAA domain Pentapeptide_4 PF13599.6 ETO34415.1 - 0.004 17.3 0.8 0.012 15.8 0.8 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO34415.1 - 0.016 15.8 1.9 0.061 13.9 0.0 3.2 3 0 0 3 3 3 0 AAA domain Cytochrom_D1 PF02239.16 ETO34415.1 - 0.017 13.6 4.6 7.7 4.9 0.1 5.0 4 3 2 6 6 6 0 Cytochrome D1 heme domain RNA_helicase PF00910.22 ETO34415.1 - 0.044 14.2 0.3 0.31 11.4 0.0 2.8 2 0 0 2 2 1 0 RNA helicase AAA PF00004.29 ETO34415.1 - 0.072 13.5 0.0 0.99 9.8 0.0 2.7 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Sigma54_activat PF00158.26 ETO34415.1 - 0.081 12.6 0.0 0.22 11.2 0.0 1.7 1 0 0 1 1 1 0 Sigma-54 interaction domain Pentapeptide_3 PF13576.6 ETO34415.1 - 0.41 10.8 1.7 0.61 10.3 0.1 2.1 2 0 0 2 2 2 0 Pentapeptide repeats (9 copies) ABC_tran PF00005.27 ETO34415.1 - 0.47 11.0 2.6 4.6 7.8 0.0 3.8 4 0 0 4 4 4 0 ABC transporter PD40 PF07676.12 ETO34415.1 - 0.87 9.6 18.4 59 3.8 0.0 9.2 12 0 0 12 12 11 0 WD40-like Beta Propeller Repeat VbhA PF18495.1 ETO34416.1 - 0.00031 20.5 0.0 0.00061 19.6 0.0 1.4 1 0 0 1 1 1 1 Antitoxin VbhA PP_kinase_C PF13090.6 ETO34416.1 - 0.2 11.1 0.2 0.58 9.6 0.0 1.7 2 0 0 2 2 2 0 Polyphosphate kinase C-terminal domain 2 DUF3439 PF11921.8 ETO34416.1 - 0.24 11.4 9.8 0.51 10.3 9.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) BAP PF06639.11 ETO34416.1 - 0.72 10.2 5.7 1.6 9.2 5.7 1.5 1 0 0 1 1 1 0 Basal layer antifungal peptide (BAP) Gly-zipper_YMGG PF13441.6 ETO34416.1 - 1.3 8.8 14.8 2.7 7.8 4.7 2.7 2 0 0 2 2 2 0 YMGG-like Gly-zipper Gly-zipper_Omp PF13488.6 ETO34416.1 - 2 8.5 18.6 10 6.2 17.6 2.4 1 1 1 2 2 2 0 Glycine zipper SSP160 PF06933.11 ETO34416.1 - 2 6.5 14.3 3.9 5.6 14.3 1.4 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 PNISR PF15996.5 ETO34417.1 - 0.21 11.8 8.5 0.25 11.6 8.5 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR DUF4551 PF15087.6 ETO34417.1 - 1.7 7.4 4.3 1.7 7.4 4.3 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Macoilin PF09726.9 ETO34417.1 - 5 5.6 9.5 5 5.6 9.5 1.0 1 0 0 1 1 1 0 Macoilin family TetM_leader PF08076.11 ETO34419.1 - 0.098 12.5 0.6 0.28 11.0 0.6 1.8 1 0 0 1 1 1 0 Tetracycline resistance determinant leader peptide ubiquitin PF00240.23 ETO34421.1 - 0.0017 18.1 0.0 0.004 16.9 0.0 1.6 1 0 0 1 1 1 1 Ubiquitin family Sde2_N_Ubi PF13019.6 ETO34421.1 - 0.11 12.3 0.4 0.81 9.5 0.0 2.1 2 0 0 2 2 2 0 Silencing defective 2 N-terminal ubiquitin domain Cytomega_TRL10 PF06084.11 ETO34421.1 - 0.13 12.2 0.0 0.39 10.7 0.0 1.7 2 0 0 2 2 2 0 Cytomegalovirus TRL10 protein Proteasome PF00227.26 ETO34422.1 - 1.9e-12 47.0 0.1 1.8e-11 43.9 0.1 1.9 1 1 0 1 1 1 1 Proteasome subunit P5CR_dimer PF14748.6 ETO34422.1 - 0.045 14.0 0.0 0.068 13.4 0.0 1.3 1 0 0 1 1 1 0 Pyrroline-5-carboxylate reductase dimerisation Ribosomal_S2 PF00318.20 ETO34423.1 - 2.7e-06 26.8 0.0 3.6e-06 26.4 0.0 1.2 1 0 0 1 1 1 1 Ribosomal protein S2 40S_SA_C PF16122.5 ETO34423.1 - 1.6 10.2 7.6 0.91 10.9 6.0 1.6 2 0 0 2 2 2 0 40S ribosomal protein SA C-terminus FGGY_C PF02782.16 ETO34426.1 - 5.2e-21 75.3 0.0 7.7e-21 74.7 0.0 1.3 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, C-terminal domain FGGY_N PF00370.21 ETO34427.1 - 9.6e-10 38.4 0.0 9.6e-07 28.6 0.0 2.5 3 0 0 3 3 3 2 FGGY family of carbohydrate kinases, N-terminal domain Pkinase PF00069.25 ETO34429.1 - 5.1e-65 219.5 0.0 8.7e-65 218.7 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34429.1 - 6.5e-24 84.6 0.0 9.5e-24 84.1 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO34429.1 - 1.3e-17 61.9 8.7 2.1e-06 26.9 0.1 4.7 3 1 1 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO34429.1 - 1.1e-13 51.5 11.0 1.5e-08 35.0 3.1 4.1 2 1 1 3 3 3 2 EF-hand domain pair EF-hand_6 PF13405.6 ETO34429.1 - 1.3e-11 43.4 15.4 0.0026 17.6 0.1 5.1 4 1 1 5 5 5 4 EF-hand domain EF-hand_5 PF13202.6 ETO34429.1 - 1.9e-10 39.7 5.5 0.0027 17.1 0.1 4.0 3 0 0 3 3 3 3 EF hand EF-hand_8 PF13833.6 ETO34429.1 - 5.3e-08 32.6 5.7 0.0088 15.9 0.2 4.5 4 0 0 4 4 4 3 EF-hand domain pair APH PF01636.23 ETO34429.1 - 3.6e-05 23.8 0.1 7.6e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO34429.1 - 0.00013 21.6 0.5 0.00032 20.4 0.5 1.6 1 0 0 1 1 1 1 RIO1 family YrbL-PhoP_reg PF10707.9 ETO34429.1 - 0.0099 15.4 0.0 0.027 14.0 0.0 1.7 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Pkinase_fungal PF17667.1 ETO34429.1 - 0.015 14.1 0.3 0.042 12.6 0.0 1.7 2 1 0 2 2 2 0 Fungal protein kinase Choline_kinase PF01633.20 ETO34429.1 - 0.02 14.5 0.4 0.044 13.3 0.0 1.7 2 0 0 2 2 2 0 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 ETO34429.1 - 0.029 13.3 0.2 0.029 13.3 0.2 1.9 2 0 0 2 2 2 0 Poxvirus serine/threonine protein kinase EF-hand_4 PF12763.7 ETO34429.1 - 0.067 13.1 0.1 0.19 11.7 0.1 1.7 1 0 0 1 1 1 0 Cytoskeletal-regulatory complex EF hand SPARC_Ca_bdg PF10591.9 ETO34429.1 - 0.18 12.2 3.9 0.71 10.2 0.1 3.0 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region NACHT PF05729.12 ETO34430.1 - 9.7e-08 32.1 0.0 1.5e-07 31.5 0.0 1.3 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO34430.1 - 0.0021 17.3 0.4 0.0071 15.6 0.0 1.8 2 0 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 ETO34430.1 - 0.0086 16.5 0.0 0.024 15.0 0.0 1.7 2 0 0 2 2 2 1 AAA ATPase domain Torsin PF06309.11 ETO34430.1 - 0.013 15.6 0.1 0.023 14.8 0.1 1.4 1 0 0 1 1 1 0 Torsin SMC_N PF02463.19 ETO34430.1 - 0.017 14.6 1.8 0.038 13.4 0.1 2.0 2 0 0 2 2 2 0 RecF/RecN/SMC N terminal domain PRK PF00485.18 ETO34430.1 - 0.039 13.7 0.5 9.1 6.0 0.0 2.2 2 0 0 2 2 2 0 Phosphoribulokinase / Uridine kinase family AAA_22 PF13401.6 ETO34430.1 - 0.085 13.1 0.0 0.22 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain DUF87 PF01935.17 ETO34430.1 - 1 9.4 0.1 1 9.4 0.1 2.1 1 1 1 2 2 2 0 Helicase HerA, central domain Methyltransf_29 PF03141.16 ETO34431.1 - 0.052 12.1 0.0 0.056 12.0 0.0 1.1 1 0 0 1 1 1 0 Putative S-adenosyl-L-methionine-dependent methyltransferase HEAT PF02985.22 ETO34432.1 - 8.9e-05 22.4 0.1 0.014 15.6 0.0 3.6 4 0 0 4 4 4 1 HEAT repeat CLASP_N PF12348.8 ETO34432.1 - 0.00061 19.4 0.7 0.0074 15.9 0.0 2.6 3 1 0 3 3 3 1 CLASP N terminal HEAT_EZ PF13513.6 ETO34432.1 - 0.0023 18.4 0.0 0.26 11.9 0.0 3.0 2 1 0 2 2 2 1 HEAT-like repeat Cnd1 PF12717.7 ETO34432.1 - 0.03 14.4 0.1 4.2 7.4 0.0 2.5 2 1 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO34432.1 - 0.03 14.9 0.9 1.9 9.1 0.0 2.9 2 1 2 4 4 4 0 Vacuolar 14 Fab1-binding region RTP1_C1 PF10363.9 ETO34432.1 - 0.046 13.9 0.0 0.19 11.9 0.0 2.2 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 HEAT_PBS PF03130.16 ETO34432.1 - 0.09 13.5 0.0 82 4.3 0.0 3.6 3 0 0 3 3 3 0 PBS lyase HEAT-like repeat DB PF01682.19 ETO34432.1 - 0.17 12.2 1.8 5 7.5 0.1 2.6 1 1 1 2 2 2 0 DB module zf-RING_2 PF13639.6 ETO34434.1 - 0.11 12.8 0.4 0.11 12.8 0.4 2.9 2 2 0 2 2 2 0 Ring finger domain Stevor PF17410.2 ETO34436.1 - 0.0045 16.6 0.0 0.0045 16.6 0.0 2.2 2 0 0 2 2 2 1 Subtelomeric Variable Open Reading frame Pex14_N PF04695.13 ETO34436.1 - 0.0066 17.1 1.3 0.0066 17.1 1.3 1.9 2 0 0 2 2 1 1 Peroxisomal membrane anchor protein (Pex14p) conserved region DUF4381 PF14316.6 ETO34436.1 - 0.0098 16.1 0.0 0.02 15.1 0.0 1.4 1 0 0 1 1 1 1 Domain of unknown function (DUF4381) Saf_2TM PF18303.1 ETO34436.1 - 0.01 15.5 1.8 0.034 13.7 0.0 2.3 2 0 0 2 2 2 0 SAVED-fused 2TM effector domain TMIE PF16038.5 ETO34436.1 - 0.013 15.3 0.1 0.048 13.5 0.1 2.0 1 0 0 1 1 1 0 TMIE protein MFS_1 PF07690.16 ETO34436.1 - 0.019 13.9 0.0 0.064 12.2 0.0 1.7 1 1 0 1 1 1 0 Major Facilitator Superfamily LapA_dom PF06305.11 ETO34436.1 - 0.02 14.7 0.5 0.046 13.5 0.5 1.5 1 0 0 1 1 1 0 Lipopolysaccharide assembly protein A domain SARAF PF06682.12 ETO34436.1 - 0.023 14.4 1.2 0.091 12.4 0.1 2.2 2 0 0 2 2 2 0 SOCE-associated regulatory factor of calcium homoeostasis SP_C-Propep PF08999.10 ETO34436.1 - 0.026 14.3 0.1 0.078 12.8 0.1 1.8 1 0 0 1 1 1 0 Surfactant protein C, N terminal propeptide EphA2_TM PF14575.6 ETO34436.1 - 0.049 14.5 2.8 0.05 14.5 0.0 2.5 3 0 0 3 3 1 0 Ephrin type-A receptor 2 transmembrane domain SIT PF15330.6 ETO34436.1 - 0.089 13.2 0.2 0.089 13.2 0.2 2.3 2 1 0 2 2 1 0 SHP2-interacting transmembrane adaptor protein, SIT DUF2615 PF11027.8 ETO34436.1 - 1.7 8.8 0.0 1.7 8.8 0.0 3.8 4 1 0 4 4 3 0 Protein of unknown function (DUF2615) DUF3139 PF11337.8 ETO34436.1 - 1.9 9.2 4.4 3.4 8.4 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) Pex24p PF06398.11 ETO34436.1 - 3.3 6.6 9.3 3.5 6.5 6.2 2.3 1 1 1 2 2 2 0 Integral peroxisomal membrane peroxin SNARE PF05739.19 ETO34436.1 - 8.4 6.5 7.6 0.9 9.6 0.2 2.9 3 0 0 3 3 3 0 SNARE domain Sugar_tr PF00083.24 ETO34437.1 - 3.9e-12 45.8 3.3 2.2e-05 23.5 1.1 2.3 2 0 0 2 2 2 2 Sugar (and other) transporter MFS_1 PF07690.16 ETO34437.1 - 5.7e-11 41.9 12.7 6.3e-08 31.9 4.9 2.1 2 0 0 2 2 2 2 Major Facilitator Superfamily SelK_SelG PF10961.8 ETO34437.1 - 0.0014 19.2 0.1 0.0037 17.8 0.1 1.7 1 0 0 1 1 1 1 Selenoprotein SelK_SelG Ac76 PF05814.11 ETO34437.1 - 0.0093 15.9 0.0 0.023 14.7 0.0 1.6 1 0 0 1 1 1 1 Orf76 (Ac76) DUF4064 PF13273.6 ETO34437.1 - 0.02 15.2 1.8 0.02 15.2 1.8 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF4064) Sigma_reg_N PF13800.6 ETO34437.1 - 0.021 15.1 0.1 0.021 15.1 0.1 2.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal ETRAMP PF09716.10 ETO34437.1 - 1.6 8.9 5.7 0.84 9.7 0.6 2.6 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF1738 PF08401.11 ETO34438.1 - 0.078 13.1 0.9 0.14 12.2 0.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1738) An_peroxidase PF03098.15 ETO34440.1 - 1.8e-51 175.3 0.6 1e-34 120.0 0.0 3.0 2 1 1 3 3 3 3 Animal haem peroxidase DOMON PF03351.17 ETO34441.1 - 3.9e-15 56.2 0.1 6.5e-15 55.5 0.1 1.4 1 0 0 1 1 1 1 DOMON domain An_peroxidase PF03098.15 ETO34441.1 - 3.8e-12 45.6 0.0 4.9e-12 45.2 0.0 1.1 1 0 0 1 1 1 1 Animal haem peroxidase MatE PF01554.18 ETO34441.1 - 0.037 13.7 0.8 0.037 13.7 0.8 2.1 2 0 0 2 2 2 0 MatE Trep_Strep PF09605.10 ETO34441.1 - 0.17 11.9 3.5 0.17 11.8 0.7 2.3 2 0 0 2 2 2 0 Hypothetical bacterial integral membrane protein (Trep_Strep) zf-CCHC_3 PF13917.6 ETO34442.1 - 2.3e-08 33.8 8.9 5.6e-08 32.6 8.9 1.6 1 0 0 1 1 1 1 Zinc knuckle Macoilin PF09726.9 ETO34442.1 - 0.012 14.2 26.6 0.015 13.9 26.6 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 ETO34442.1 - 1.5 5.9 22.6 1.7 5.7 22.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer ALMT PF11744.8 ETO34442.1 - 2.3 7.0 18.9 3 6.6 18.9 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter LMBR1 PF04791.16 ETO34442.1 - 6.4 5.6 10.3 8.9 5.1 10.3 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein F-box-like PF12937.7 ETO34444.1 - 0.019 14.9 0.0 0.032 14.1 0.0 1.3 1 0 0 1 1 1 0 F-box-like CAP_N PF01213.19 ETO34444.1 - 0.049 13.1 1.1 0.097 12.1 1.1 1.5 1 0 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal PRIMA1 PF16101.5 ETO34444.1 - 0.46 10.5 3.1 1.1 9.3 3.1 1.6 1 0 0 1 1 1 0 Proline-rich membrane anchor 1 DUF3682 PF12446.8 ETO34444.1 - 5.4 7.5 12.7 6.1 7.3 4.9 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3682) ECH_1 PF00378.20 ETO34445.1 - 6.8e-33 114.0 0.0 7.7e-33 113.8 0.0 1.0 1 0 0 1 1 1 1 Enoyl-CoA hydratase/isomerase ECH_2 PF16113.5 ETO34445.1 - 8.3e-09 35.4 0.0 1.4e-08 34.6 0.0 1.3 1 1 0 1 1 1 1 Enoyl-CoA hydratase/isomerase BBP2_2 PF10082.9 ETO34446.1 - 0.38 9.6 8.9 0.38 9.6 8.9 1.0 1 0 0 1 1 1 0 Putative beta-barrel porin 2 RRM_1 PF00076.22 ETO34447.1 - 1.4e-16 60.0 0.0 2.4e-16 59.3 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_5 PF13893.6 ETO34447.1 - 0.055 13.1 0.1 0.099 12.2 0.1 1.5 1 0 0 1 1 1 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) CoaE PF01121.20 ETO34448.1 - 8.2e-26 90.8 0.9 5e-25 88.2 0.9 1.9 1 1 0 1 1 1 1 Dephospho-CoA kinase AAA_18 PF13238.6 ETO34448.1 - 0.00015 22.3 2.3 0.00051 20.6 1.6 2.2 1 1 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO34448.1 - 0.0061 16.8 0.1 0.012 15.9 0.1 1.5 1 0 0 1 1 1 1 AAA domain AAA_13 PF13166.6 ETO34448.1 - 0.008 14.9 6.6 0.13 10.9 0.1 2.3 2 1 0 2 2 2 2 AAA domain OAF PF14941.6 ETO34448.1 - 0.0095 15.4 0.8 0.013 14.9 0.0 1.6 2 0 0 2 2 2 1 Transcriptional regulator, Out at first ABC_tran PF00005.27 ETO34448.1 - 0.015 15.8 2.8 0.028 14.9 2.8 1.8 1 1 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ETO34448.1 - 0.016 15.4 0.1 0.06 13.5 0.0 1.9 2 0 0 2 2 2 0 AAA domain GTP_EFTU PF00009.27 ETO34448.1 - 0.018 14.6 0.3 0.018 14.6 0.3 2.1 2 1 0 2 2 2 0 Elongation factor Tu GTP binding domain dNK PF01712.19 ETO34448.1 - 0.024 14.5 2.0 0.027 14.4 0.1 1.9 2 1 0 2 2 2 0 Deoxynucleoside kinase ATP_bind_1 PF03029.17 ETO34448.1 - 0.045 13.5 0.1 0.1 12.3 0.1 1.7 1 1 0 1 1 1 0 Conserved hypothetical ATP binding protein AAA_28 PF13521.6 ETO34448.1 - 0.059 13.6 0.3 0.12 12.7 0.1 1.8 1 1 0 1 1 1 0 AAA domain BOP1NT PF08145.12 ETO34448.1 - 0.11 12.4 0.2 0.11 12.4 0.2 1.8 2 0 0 2 2 2 0 BOP1NT (NUC169) domain T2SSE PF00437.20 ETO34448.1 - 0.11 11.5 1.6 4 6.4 0.0 2.7 3 0 0 3 3 3 0 Type II/IV secretion system protein AAA_17 PF13207.6 ETO34448.1 - 0.2 12.1 1.7 0.31 11.5 0.1 2.1 2 1 0 2 2 2 0 AAA domain G0-G1_switch_2 PF15103.6 ETO34449.1 - 4.6 7.7 8.1 5.1 7.6 8.1 1.0 1 0 0 1 1 1 0 G0/G1 switch protein 2 Pkinase PF00069.25 ETO34450.1 - 4.8e-32 111.4 0.0 5.9e-32 111.1 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34450.1 - 0.00014 21.2 0.1 0.00024 20.5 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO34450.1 - 0.00032 19.6 0.0 0.00045 19.1 0.0 1.1 1 0 0 1 1 1 1 Fungal protein kinase IPK PF03770.16 ETO34450.1 - 0.0094 15.8 1.4 0.015 15.2 1.4 1.2 1 0 0 1 1 1 1 Inositol polyphosphate kinase CRM1_repeat_2 PF18784.1 ETO34450.1 - 0.12 12.0 2.6 0.25 11.0 2.6 1.4 1 0 0 1 1 1 0 CRM1 / Exportin repeat 2 PH PF00169.29 ETO34451.1 - 1.3e-07 32.1 0.5 1.3e-07 32.1 0.5 2.0 2 0 0 2 2 2 1 PH domain Zip PF02535.22 ETO34451.1 - 0.055 12.7 0.2 0.08 12.1 0.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4834 PF16118.5 ETO34451.1 - 0.11 13.4 2.8 0.37 11.8 2.8 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) FAM60A PF15396.6 ETO34451.1 - 0.9 9.5 10.6 0.65 10.0 4.6 2.1 2 0 0 2 2 2 0 Protein Family FAM60A PB1 PF00564.24 ETO34452.1 - 0.094 12.7 0.0 0.13 12.2 0.0 1.3 1 0 0 1 1 1 0 PB1 domain Myc_N PF01056.18 ETO34453.1 - 5.9 6.7 14.8 0.3 10.9 4.2 2.6 3 0 0 3 3 3 0 Myc amino-terminal region HEAT PF02985.22 ETO34455.1 - 7.2e-08 32.0 0.8 0.68 10.4 0.0 6.5 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 ETO34455.1 - 5.1e-07 30.0 0.3 0.045 14.2 0.0 5.1 4 2 2 6 6 6 2 HEAT repeats Ank_5 PF13857.6 ETO34455.1 - 0.0065 16.8 0.0 0.019 15.2 0.0 1.9 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Cnd1 PF12717.7 ETO34455.1 - 0.011 15.8 4.9 0.011 15.8 4.9 5.1 3 2 0 4 4 4 0 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO34455.1 - 0.015 15.8 0.1 0.59 10.7 0.0 3.9 6 1 1 7 7 7 0 HEAT-like repeat N_Asn_amidohyd PF14736.6 ETO34455.1 - 0.042 13.0 2.4 0.28 10.3 0.3 2.9 2 1 1 3 3 3 0 Protein N-terminal asparagine amidohydrolase Ank_3 PF13606.6 ETO34455.1 - 0.047 14.2 0.0 0.41 11.4 0.0 2.8 1 0 0 1 1 1 0 Ankyrin repeat Ank_2 PF12796.7 ETO34455.1 - 0.077 13.6 0.1 1.1 9.9 0.0 3.0 3 0 0 3 3 3 0 Ankyrin repeats (3 copies) DUF5071 PF16804.5 ETO34455.1 - 1.4 9.2 12.4 0.17 12.2 0.5 3.9 3 1 1 4 4 4 0 Domain of unknown function (DUF5071) OSTMP1 PF09777.9 ETO34456.1 - 0.013 14.9 0.9 0.015 14.7 0.9 1.1 1 0 0 1 1 1 0 Osteopetrosis-associated transmembrane protein 1 precursor PMR5N PF14416.6 ETO34456.1 - 0.036 14.4 0.4 0.082 13.2 0.0 1.7 2 1 1 3 3 3 0 PMR5 N terminal Domain GRASP55_65 PF04495.14 ETO34457.1 - 0.17 12.2 0.1 1 9.7 0.0 2.0 2 1 0 2 2 2 0 GRASP55/65 PDZ-like domain PigN PF04987.14 ETO34459.1 - 0.0023 16.9 0.0 0.004 16.1 0.0 1.3 1 0 0 1 1 1 1 Phosphatidylinositolglycan class N (PIG-N) DUF2207 PF09972.9 ETO34459.1 - 0.018 13.8 0.0 0.031 13.1 0.0 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) 7tm_1 PF00001.21 ETO34459.1 - 0.043 13.1 0.3 0.075 12.3 0.4 1.5 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) EssA PF10661.9 ETO34459.1 - 0.045 13.6 0.1 0.045 13.6 0.1 2.2 2 1 0 2 2 2 0 WXG100 protein secretion system (Wss), protein EssA TMEM132D_C PF15706.5 ETO34459.1 - 0.086 12.6 0.2 0.52 10.1 0.1 2.3 2 0 0 2 2 2 0 Mature oligodendrocyte transmembrane protein, TMEM132D, C-term Syndecan PF01034.20 ETO34459.1 - 0.34 10.9 2.7 0.99 9.4 2.7 1.8 1 0 0 1 1 1 0 Syndecan domain EphA2_TM PF14575.6 ETO34459.1 - 0.51 11.2 4.5 0.5 11.3 0.8 2.7 3 0 0 3 3 3 0 Ephrin type-A receptor 2 transmembrane domain PAP2 PF01569.21 ETO34460.1 - 6e-05 22.8 1.4 6e-05 22.8 1.4 2.5 3 0 0 3 3 3 1 PAP2 superfamily Transposase_24 PF03004.14 ETO34460.1 - 0.015 15.4 0.5 0.029 14.5 0.5 1.4 1 0 0 1 1 1 0 Plant transposase (Ptta/En/Spm family) RRN3 PF05327.11 ETO34461.1 - 8.9e-05 21.2 2.1 9.5e-05 21.1 2.1 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 DUF2207 PF09972.9 ETO34461.1 - 0.00074 18.4 0.4 0.00085 18.2 0.4 1.0 1 0 0 1 1 1 1 Predicted membrane protein (DUF2207) EVI2A PF05399.11 ETO34461.1 - 0.0094 15.6 1.1 0.017 14.7 1.1 1.5 1 0 0 1 1 1 1 Ectropic viral integration site 2A protein (EVI2A) NPR3 PF03666.13 ETO34461.1 - 0.014 14.2 0.9 0.014 14.2 0.9 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 MDFI PF15316.6 ETO34461.1 - 0.075 13.1 3.7 0.12 12.5 3.7 1.3 1 0 0 1 1 1 0 MyoD family inhibitor DUF443 PF04276.12 ETO34461.1 - 0.12 12.2 4.3 0.15 11.8 3.9 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF443) TRIQK PF15168.6 ETO34461.1 - 0.21 11.5 1.2 0.93 9.4 0.3 2.4 2 0 0 2 2 2 0 Triple QxxK/R motif-containing protein family DUF2417 PF10329.9 ETO34461.1 - 0.49 9.8 7.4 0.75 9.2 7.2 1.5 1 1 0 1 1 1 0 Region of unknown function (DUF2417) FAM76 PF16046.5 ETO34461.1 - 7.6 5.8 14.7 16 4.8 14.1 1.7 2 0 0 2 2 2 0 FAM76 protein DUF2956 PF11169.8 ETO34461.1 - 8.6 6.6 12.7 67 3.7 0.0 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF2956) LRR_8 PF13855.6 ETO34462.1 - 4.7e-07 29.5 0.6 4.7e-07 29.5 0.6 3.6 4 1 0 4 4 4 1 Leucine rich repeat LRR_4 PF12799.7 ETO34462.1 - 1.1e-05 25.7 7.5 0.00057 20.2 0.5 5.2 3 1 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO34462.1 - 0.0038 17.6 7.0 8.4 7.4 0.1 6.1 5 0 0 5 5 5 1 Leucine Rich Repeat UPF0139 PF03669.13 ETO34462.1 - 3.5 7.5 6.6 7.7 6.5 1.4 2.7 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0139) LRR_6 PF13516.6 ETO34462.1 - 6.4 7.1 6.1 10 6.4 0.1 3.7 3 0 0 3 3 3 0 Leucine Rich repeat mTERF PF02536.14 ETO34464.1 - 0.015 14.2 4.3 0.041 12.8 1.7 2.2 2 1 0 2 2 2 0 mTERF FAM76 PF16046.5 ETO34464.1 - 0.11 11.9 1.2 0.14 11.5 1.2 1.1 1 0 0 1 1 1 0 FAM76 protein SH3_4 PF06347.13 ETO34466.1 - 0.22 11.4 0.0 0.39 10.6 0.0 1.3 1 0 0 1 1 1 0 Bacterial SH3 domain Dicty_CAR PF05462.11 ETO34467.1 - 5.1e-14 52.1 16.0 6e-13 48.6 10.1 2.1 2 0 0 2 2 2 2 Slime mold cyclic AMP receptor 7tm_2 PF00002.24 ETO34467.1 - 1.9e-10 40.4 19.2 1e-09 38.0 10.0 2.4 3 0 0 3 3 3 2 7 transmembrane receptor (Secretin family) 7tm_1 PF00001.21 ETO34467.1 - 0.017 14.4 11.5 0.73 9.1 11.5 2.1 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Frizzled PF01534.17 ETO34467.1 - 1.4 7.8 15.2 0.29 10.1 10.0 2.0 1 1 1 2 2 2 0 Frizzled/Smoothened family membrane region Shadoo PF14999.6 ETO34468.1 - 0.17 12.0 0.0 0.33 11.1 0.0 1.4 1 0 0 1 1 1 0 Shadow of prion protein, neuroprotective WD40 PF00400.32 ETO34469.1 - 1.1e-34 117.9 25.8 7.4e-07 29.8 0.3 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34469.1 - 1e-12 48.2 2.4 0.024 14.9 0.0 5.1 2 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34469.1 - 1.1e-10 40.9 4.5 0.0016 17.2 0.9 4.5 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34469.1 - 2.1e-05 24.0 6.8 0.2 11.0 0.0 4.9 2 2 4 6 6 6 3 WD40-like domain DUF5570 PF17731.1 ETO34469.1 - 0.057 13.5 0.7 4.7 7.3 0.1 2.8 2 1 1 3 3 3 0 Family of unknown function (DUF5570) Ricin_B_lectin PF00652.22 ETO34470.1 - 0.033 14.4 0.1 0.048 13.9 0.1 1.3 1 0 0 1 1 1 0 Ricin-type beta-trefoil lectin domain DUF4524 PF15025.6 ETO34470.1 - 0.086 12.6 0.2 0.14 11.9 0.2 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4524) DUF3808 PF10300.9 ETO34471.1 - 0.065 12.0 0.9 0.079 11.7 0.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3808) CRA PF06589.11 ETO34471.1 - 4.4 7.4 13.2 4.2e+02 1.0 13.2 2.3 1 1 0 1 1 1 0 Circumsporozoite-related antigen (CRA) G-alpha PF00503.20 ETO34472.1 - 1e-24 87.4 4.2 2e-17 63.4 0.9 2.1 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO34472.1 - 0.0089 15.5 0.2 0.12 11.8 0.1 2.3 2 0 0 2 2 2 1 ADP-ribosylation factor family DUF3671 PF12420.8 ETO34472.1 - 0.016 15.2 1.0 0.033 14.3 1.0 1.5 1 0 0 1 1 1 0 Protein of unknown function Virul_fac_BrkB PF03631.15 ETO34472.1 - 0.023 14.3 3.7 0.034 13.8 3.7 1.2 1 0 0 1 1 1 0 Virulence factor BrkB S4 PF01479.25 ETO34474.1 - 0.35 10.6 2.2 0.78 9.5 0.0 2.8 4 0 0 4 4 4 0 S4 domain WD40 PF00400.32 ETO34475.1 - 4.5e-39 131.7 28.7 1.3e-06 29.0 0.6 7.7 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34475.1 - 1.5e-07 31.6 3.8 0.054 13.8 0.0 5.6 4 2 2 6 6 6 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34475.1 - 1.7e-07 30.3 6.4 0.16 10.6 0.1 5.0 2 1 1 5 5 5 4 Nucleoporin Nup120/160 DUF1030 PF06270.11 ETO34475.1 - 3.2 7.6 5.1 1.5 8.6 0.4 2.7 3 0 0 3 3 3 0 Protein of unknown function (DUF1030) Spb1_C PF07780.12 ETO34476.1 - 0.055 13.1 1.6 0.073 12.7 1.6 1.2 1 0 0 1 1 1 0 Spb1 C-terminal domain KASH_CCD PF14662.6 ETO34477.1 - 4.3e-05 23.4 6.9 0.26 11.1 1.4 3.3 1 1 2 3 3 3 2 Coiled-coil region of CCDC155 or KASH GAS PF13851.6 ETO34477.1 - 0.03 13.7 0.4 0.03 13.7 0.4 2.9 3 1 1 4 4 4 0 Growth-arrest specific micro-tubule binding UPF0242 PF06785.11 ETO34477.1 - 0.059 13.5 6.0 0.15 12.1 6.0 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus MAD PF05557.13 ETO34477.1 - 0.15 10.4 9.5 0.35 9.2 6.9 2.0 2 0 0 2 2 2 0 Mitotic checkpoint protein CENP-F_leu_zip PF10473.9 ETO34477.1 - 0.24 11.4 10.4 0.054 13.5 6.3 2.1 3 1 0 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 DUF5595 PF18077.1 ETO34477.1 - 0.74 9.9 4.8 1.3 9.2 0.4 2.9 2 1 1 3 3 3 0 Domain of unknown function (DUF5595) Muted PF14942.6 ETO34477.1 - 0.76 10.1 8.3 7.4 6.9 0.6 3.0 2 1 1 3 3 3 0 Organelle biogenesis, Muted-like protein APG6_N PF17675.1 ETO34477.1 - 0.81 10.2 10.9 0.066 13.7 5.0 2.2 3 0 0 3 3 3 0 Apg6 coiled-coil region Sec5 PF15469.6 ETO34477.1 - 1.4 8.7 8.6 12 5.7 0.2 3.6 3 1 1 4 4 4 0 Exocyst complex component Sec5 PRKG1_interact PF15898.5 ETO34477.1 - 3 8.8 12.7 1.3 10.0 7.1 2.9 3 1 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF2205 PF10224.9 ETO34477.1 - 3.3 7.8 10.1 0.33 11.0 3.8 2.6 3 1 0 3 3 3 0 Short coiled-coil protein TMF_TATA_bd PF12325.8 ETO34477.1 - 6.2 7.1 11.7 1.6 8.9 0.6 3.3 3 1 1 4 4 4 0 TATA element modulatory factor 1 TATA binding TMF_DNA_bd PF12329.8 ETO34477.1 - 9.5 6.3 14.2 0.11 12.4 4.3 2.6 2 1 1 3 3 3 0 TATA element modulatory factor 1 DNA binding Arf PF00025.21 ETO34478.1 - 9.4e-25 87.1 0.8 8.8e-24 83.9 0.8 2.0 1 1 0 1 1 1 1 ADP-ribosylation factor family Ras PF00071.22 ETO34478.1 - 2.4e-08 33.7 0.2 3.2e-07 30.1 0.2 2.3 1 1 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 ETO34478.1 - 1.8e-05 24.7 0.5 0.061 13.2 0.1 2.2 2 0 0 2 2 2 2 RsgA GTPase ABC_tran PF00005.27 ETO34478.1 - 0.00013 22.5 0.0 0.00049 20.6 0.0 1.7 1 1 0 1 1 1 1 ABC transporter MMR_HSR1 PF01926.23 ETO34478.1 - 0.00025 21.1 0.1 0.00053 20.0 0.1 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase SRPRB PF09439.10 ETO34478.1 - 0.00029 20.3 0.8 0.0048 16.4 0.8 2.1 1 1 0 1 1 1 1 Signal recognition particle receptor beta subunit Roc PF08477.13 ETO34478.1 - 0.00078 19.7 0.2 0.0071 16.6 0.2 2.1 1 1 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase AAA_22 PF13401.6 ETO34478.1 - 0.0023 18.2 0.0 0.0032 17.7 0.0 1.2 1 0 0 1 1 1 1 AAA domain NACHT PF05729.12 ETO34478.1 - 0.028 14.4 2.0 0.35 10.8 2.0 2.0 1 1 0 1 1 1 0 NACHT domain ATP_bind_1 PF03029.17 ETO34478.1 - 0.065 13.0 0.5 2.8 7.6 0.1 2.2 2 0 0 2 2 2 0 Conserved hypothetical ATP binding protein G-alpha PF00503.20 ETO34478.1 - 0.079 12.1 6.6 1.2 8.2 0.1 2.8 1 1 2 3 3 3 0 G-protein alpha subunit AAA_18 PF13238.6 ETO34478.1 - 0.087 13.4 0.1 0.13 12.8 0.1 1.5 1 1 0 1 1 1 0 AAA domain AAA_29 PF13555.6 ETO34478.1 - 0.096 12.4 0.0 0.2 11.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO34478.1 - 0.12 12.9 2.3 1.4 9.4 2.3 2.1 1 1 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO34478.1 - 0.18 11.9 0.2 0.27 11.4 0.2 1.5 1 1 0 1 1 1 0 AAA domain FAST_1 PF06743.15 ETO34479.1 - 0.11 12.4 0.2 0.68 9.9 0.0 2.4 2 0 0 2 2 2 0 FAST kinase-like protein, subdomain 1 AAA_6 PF12774.7 ETO34480.1 - 2.5e-39 135.2 0.3 2.1e-19 69.6 0.4 2.2 1 1 1 2 2 2 2 Hydrolytic ATP binding site of dynein motor region AAA_5 PF07728.14 ETO34480.1 - 3.2e-13 49.9 0.0 7.8e-13 48.6 0.0 1.7 2 0 0 2 2 2 1 AAA domain (dynein-related subfamily) AAA_18 PF13238.6 ETO34480.1 - 0.0065 17.0 0.1 0.17 12.4 0.0 2.7 3 2 0 3 3 3 1 AAA domain AAA_29 PF13555.6 ETO34480.1 - 0.014 15.1 0.0 0.041 13.6 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain HMG_box_5 PF14887.6 ETO34480.1 - 0.038 14.0 0.4 0.08 12.9 0.4 1.5 1 0 0 1 1 1 0 HMG (high mobility group) box 5 DUF3987 PF13148.6 ETO34480.1 - 0.041 12.9 0.0 0.071 12.1 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) ABC_tran PF00005.27 ETO34480.1 - 0.069 13.7 0.1 0.27 11.7 0.0 1.9 2 1 0 2 2 2 0 ABC transporter DUF4108 PF13390.6 ETO34481.1 - 0.22 11.4 4.9 2.3 8.2 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4108) BP28CT PF08146.12 ETO34483.1 - 0.0049 16.7 1.7 0.0095 15.8 0.4 1.9 1 1 0 2 2 2 1 BP28CT (NUC211) domain PhzC-PhzF PF02567.16 ETO34484.1 - 6.6e-20 71.7 0.0 6.7e-20 71.7 0.0 1.0 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein Prok-RING_4 PF14447.6 ETO34485.1 - 0.061 13.2 0.6 0.061 13.2 0.6 6.7 7 2 1 8 8 8 0 Prokaryotic RING finger family 4 CDC45 PF02724.14 ETO34485.1 - 0.26 9.5 3.6 0.44 8.8 3.6 1.3 1 0 0 1 1 1 0 CDC45-like protein DUF2722 PF10846.8 ETO34485.1 - 0.26 10.2 7.8 1.4 7.8 0.6 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2722) Ferlin_C PF16165.5 ETO34485.1 - 0.71 9.8 6.9 18 5.3 4.7 2.4 2 0 0 2 2 2 0 Ferlin C-terminus Sporozoite_P67 PF05642.11 ETO34485.1 - 9.9 4.1 5.4 14 3.6 5.4 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PDZ_6 PF17820.1 ETO34488.1 - 0.0047 16.7 0.0 0.0088 15.9 0.0 1.4 1 0 0 1 1 1 1 PDZ domain Presenilin PF01080.17 ETO34488.1 - 0.9 8.2 5.1 1.1 7.9 5.1 1.1 1 0 0 1 1 1 0 Presenilin HSP70 PF00012.20 ETO34489.1 - 7.1e-27 93.8 0.0 1.2e-26 93.2 0.0 1.3 1 0 0 1 1 1 1 Hsp70 protein 2-Hacid_dh_C PF02826.19 ETO34490.1 - 4.6e-50 169.5 0.0 8.8e-50 168.5 0.0 1.4 1 0 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 2-Hacid_dh PF00389.30 ETO34490.1 - 4e-26 91.3 0.0 1e-25 89.9 0.0 1.7 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain NAD_binding_2 PF03446.15 ETO34490.1 - 0.00031 21.0 0.1 0.0007 19.8 0.1 1.6 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase XdhC_C PF13478.6 ETO34490.1 - 0.0075 16.8 0.0 0.44 11.0 0.0 2.6 3 0 0 3 3 3 1 XdhC Rossmann domain AdoHcyase_NAD PF00670.21 ETO34490.1 - 0.011 15.8 0.1 0.023 14.8 0.1 1.5 1 0 0 1 1 1 0 S-adenosyl-L-homocysteine hydrolase, NAD binding domain UBA_3 PF09288.10 ETO34490.1 - 0.045 13.6 0.0 0.12 12.2 0.0 1.7 1 0 0 1 1 1 0 Fungal ubiquitin-associated domain Peptidase_S41_N PF11918.8 ETO34490.1 - 0.097 12.9 0.0 0.2 11.9 0.0 1.5 1 0 0 1 1 1 0 N-terminal domain of Peptidase_S41 in eukaryotic IRBP UDPG_MGDP_dh_N PF03721.14 ETO34490.1 - 0.89 9.1 3.5 3.9 7.0 0.8 2.9 1 1 2 3 3 3 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain FAM209 PF15206.6 ETO34491.1 - 0.042 13.6 2.5 0.072 12.9 1.4 1.8 2 0 0 2 2 2 0 FAM209 family Ras PF00071.22 ETO34493.1 - 1.2e-13 51.0 3.2 6.2e-05 22.6 0.0 3.9 3 1 0 3 3 3 3 Ras family Roc PF08477.13 ETO34493.1 - 4.7e-07 30.0 0.1 0.00011 22.4 0.0 3.5 3 0 0 3 3 3 1 Ras of Complex, Roc, domain of DAPkinase RsgA_GTPase PF03193.16 ETO34493.1 - 0.0068 16.3 0.4 0.15 11.9 0.0 2.8 3 0 0 3 3 3 1 RsgA GTPase Menin PF05053.13 ETO34493.1 - 1.9 6.8 16.8 0.5 8.7 12.4 2.1 2 0 0 2 2 2 0 Menin FANCI_S1-cap PF14674.6 ETO34495.1 - 0.024 14.7 0.0 0.059 13.5 0.0 1.6 1 0 0 1 1 1 0 FANCI solenoid 1 cap DUF4119 PF13494.6 ETO34495.1 - 0.34 11.1 4.9 0.86 9.8 4.9 1.8 1 1 0 1 1 1 0 Domain of unknown function, B. Theta Gene description (DUF4119) Mpp10 PF04006.12 ETO34496.1 - 0.058 11.8 13.0 0.062 11.7 13.0 1.0 1 0 0 1 1 1 0 Mpp10 protein BDV_M PF16520.5 ETO34497.1 - 0.018 15.4 0.2 8.2 6.9 0.0 2.3 2 0 0 2 2 2 0 ssRNA-binding matrix protein of Bornaviridae CPT PF07931.12 ETO34497.1 - 0.17 11.7 0.0 0.29 11.0 0.0 1.6 1 1 0 1 1 1 0 Chloramphenicol phosphotransferase-like protein TPR_11 PF13414.6 ETO34498.1 - 1.6e-12 46.9 9.1 9.3e-08 31.6 0.1 3.5 2 1 1 3 3 3 3 TPR repeat TPR_2 PF07719.17 ETO34498.1 - 9.2e-11 41.0 2.5 0.00041 20.2 0.3 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34498.1 - 6.8e-10 38.3 5.9 0.0014 18.4 0.7 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34498.1 - 1.3e-08 34.7 5.1 0.0017 18.6 0.1 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat SGTA_dimer PF16546.5 ETO34498.1 - 4.4e-07 29.6 1.0 1.1e-06 28.3 0.0 2.2 2 0 0 2 2 2 1 Homodimerisation domain of SGTA TPR_16 PF13432.6 ETO34498.1 - 9.7e-06 26.1 0.4 0.0023 18.5 0.3 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO34498.1 - 1.8e-05 25.2 0.3 0.079 13.8 0.1 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO34498.1 - 7.5e-05 23.2 0.8 0.019 15.4 0.3 3.2 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO34498.1 - 0.00044 20.5 2.4 0.049 13.9 1.1 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat GerD PF17898.1 ETO34498.1 - 0.0014 18.5 3.3 0.0014 18.5 3.3 2.2 2 0 0 2 2 2 1 Spore germination GerD central core domain MIT PF04212.18 ETO34498.1 - 0.0059 16.6 5.9 5.4 7.2 0.5 4.4 4 1 0 4 4 4 1 MIT (microtubule interacting and transport) domain STI1 PF17830.1 ETO34498.1 - 0.0073 16.2 15.9 0.11 12.5 14.6 2.7 1 1 1 2 2 2 1 STI1 domain TPR_8 PF13181.6 ETO34498.1 - 0.015 15.5 2.9 0.13 12.5 0.1 3.2 3 0 0 3 3 2 0 Tetratricopeptide repeat XPC-binding PF09280.11 ETO34498.1 - 0.061 13.1 10.2 0.073 12.8 8.3 2.2 2 0 0 2 2 2 0 XPC-binding domain TrbL PF04610.14 ETO34498.1 - 0.067 12.9 0.9 0.13 12.0 0.9 1.3 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein Dicty_REP PF05086.12 ETO34498.1 - 0.18 9.8 4.8 0.25 9.3 4.8 1.2 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein TPR_10 PF13374.6 ETO34498.1 - 0.29 11.1 1.7 0.62 10.0 0.6 2.2 3 0 0 3 3 1 0 Tetratricopeptide repeat FSA_C PF10479.9 ETO34498.1 - 0.39 8.8 5.8 0.58 8.2 5.8 1.1 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TPR_6 PF13174.6 ETO34498.1 - 0.53 11.0 3.4 1.2 9.9 1.1 2.8 2 0 0 2 2 2 0 Tetratricopeptide repeat ComX PF05952.12 ETO34498.1 - 1.6 8.7 6.7 6.9 6.7 3.8 2.5 1 1 1 2 2 2 0 Bacillus competence pheromone ComX Nas2_N PF18265.1 ETO34499.1 - 1.1e-25 89.3 0.1 2e-25 88.5 0.1 1.4 1 0 0 1 1 1 1 Nas2 N_terminal domain PDZ_6 PF17820.1 ETO34499.1 - 4.9e-08 32.7 0.0 9.3e-08 31.8 0.0 1.5 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO34499.1 - 3.7e-05 24.0 0.1 9.3e-05 22.7 0.1 1.7 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ETO34499.1 - 0.023 15.0 0.0 0.05 14.0 0.0 1.6 1 0 0 1 1 1 0 PDZ domain ZapB PF06005.12 ETO34499.1 - 0.18 12.3 0.4 0.18 12.3 0.4 2.5 3 0 0 3 3 3 0 Cell division protein ZapB BCDHK_Adom3 PF10436.9 ETO34500.1 - 4e-29 101.5 0.0 5.1e-29 101.2 0.0 1.1 1 0 0 1 1 1 1 Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase DUF1489 PF07370.11 ETO34501.1 - 0.16 11.7 0.0 0.22 11.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1489) DUF1644 PF07800.12 ETO34502.1 - 0.39 10.8 12.0 13 5.8 11.1 2.8 1 1 0 1 1 1 0 Protein of unknown function (DUF1644) WD40 PF00400.32 ETO34503.1 - 1.1e-06 29.3 0.4 1.1e-06 29.3 0.4 3.2 3 2 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34503.1 - 0.024 14.9 0.1 4.7 7.6 0.0 2.2 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34503.1 - 0.05 12.3 0.8 0.14 10.8 0.2 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 RabGAP-TBC PF00566.18 ETO34504.1 - 7.7e-17 61.7 2.1 1.7e-16 60.6 0.0 2.3 2 0 0 2 2 2 1 Rab-GTPase-TBC domain Phage_Gp23 PF10669.9 ETO34504.1 - 0.12 12.7 4.4 0.26 11.6 0.8 2.3 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) YafQ_toxin PF15738.5 ETO34504.1 - 0.16 12.3 1.4 0.4 11.0 0.1 2.1 2 0 0 2 2 2 0 Bacterial toxin of type II toxin-antitoxin system, YafQ DUF4834 PF16118.5 ETO34505.1 - 0.0048 17.8 3.4 2.1 9.4 0.0 3.7 2 1 1 3 3 3 2 Domain of unknown function (DUF4834) PI3_PI4_kinase PF00454.27 ETO34506.1 - 9.8e-09 35.4 0.5 3.2e-05 23.9 0.0 2.6 2 2 1 3 3 3 2 Phosphatidylinositol 3- and 4-kinase ACP_PD PF04336.12 ETO34506.1 - 0.065 13.7 2.1 0.068 13.6 0.3 2.0 2 0 0 2 2 2 0 Acyl carrier protein phosphodiesterase Hid1 PF12722.7 ETO34508.1 - 0.0014 16.8 25.7 0.0024 16.1 25.7 1.3 1 0 0 1 1 1 1 High-temperature-induced dauer-formation protein HBS1_N PF08938.10 ETO34509.1 - 0.02 15.2 0.2 0.039 14.3 0.2 1.4 1 0 0 1 1 1 0 HBS1 N-terminus Cwf_Cwc_15 PF04889.12 ETO34510.1 - 5.3e-40 137.7 21.4 1.8e-39 136.0 21.4 1.7 1 1 0 1 1 1 1 Cwf15/Cwc15 cell cycle control protein SAGA-Tad1 PF12767.7 ETO34510.1 - 0.037 13.7 5.7 0.044 13.5 5.7 1.2 1 0 0 1 1 1 0 Transcriptional regulator of RNA polII, SAGA, subunit PGA2 PF07543.12 ETO34510.1 - 0.27 11.2 15.8 0.48 10.4 15.8 1.4 1 1 0 1 1 1 0 Protein trafficking PGA2 Presenilin PF01080.17 ETO34510.1 - 9.2 4.9 7.5 12 4.6 7.5 1.1 1 0 0 1 1 1 0 Presenilin Skp1 PF01466.19 ETO34511.1 - 3.6e-26 91.0 0.2 3.6e-26 91.0 0.2 2.6 4 0 0 4 4 4 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETO34511.1 - 3.1e-14 52.9 0.0 6.4e-14 51.9 0.0 1.5 1 0 0 1 1 1 1 Skp1 family, tetramerisation domain BTB PF00651.31 ETO34511.1 - 3e-06 27.4 0.1 3.1e-05 24.1 0.0 2.2 2 0 0 2 2 2 1 BTB/POZ domain Myb_DNA-binding PF00249.31 ETO34511.1 - 0.091 13.0 0.1 2.2 8.5 0.0 2.5 2 0 0 2 2 2 0 Myb-like DNA-binding domain Ribosomal_L6 PF00347.23 ETO34512.1 - 0.00049 20.7 0.0 0.0014 19.2 0.0 1.8 2 0 0 2 2 2 1 Ribosomal protein L6 DUF3991 PF13154.6 ETO34512.1 - 0.072 13.5 0.2 1.3 9.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3991) WD40 PF00400.32 ETO34513.1 - 1.4e-38 130.2 20.5 9.2e-10 39.0 0.2 7.0 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34513.1 - 4.1e-17 62.2 6.0 0.016 15.5 0.0 6.0 2 2 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34513.1 - 4.5e-09 35.7 1.5 0.0065 15.5 0.1 4.7 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34513.1 - 3.2e-06 26.7 9.0 0.0014 18.0 0.3 3.2 1 1 4 5 5 5 5 WD40-like domain Nup160 PF11715.8 ETO34513.1 - 2.4e-05 23.2 5.1 0.17 10.5 0.1 3.4 1 1 1 3 3 3 3 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO34513.1 - 0.0012 17.8 7.6 0.075 11.9 0.1 3.6 2 1 2 4 4 4 2 Partner and localizer of BRCA2 WD40 domain PQQ PF01011.21 ETO34513.1 - 0.0016 18.3 0.0 13 5.9 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat Coatomer_WDAD PF04053.14 ETO34513.1 - 0.0039 16.3 4.5 0.06 12.4 0.4 2.6 1 1 1 2 2 2 2 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO34513.1 - 0.01 14.4 0.8 1.6 7.2 0.0 2.7 1 1 3 4 4 4 0 Cytochrome D1 heme domain DUF1652 PF07865.11 ETO34513.1 - 0.031 14.1 0.0 0.32 10.8 0.0 2.6 3 0 0 3 3 3 0 Protein of unknown function (DUF1652) SGL PF08450.12 ETO34513.1 - 0.034 13.7 0.1 0.12 11.9 0.0 1.9 1 1 0 1 1 1 0 SMP-30/Gluconolactonase/LRE-like region NHL PF01436.21 ETO34513.1 - 0.045 13.8 2.1 1e+02 3.2 0.0 5.1 5 0 0 5 5 5 0 NHL repeat Resistin PF06954.11 ETO34513.1 - 0.1 13.2 4.8 22 5.7 0.1 3.4 2 1 1 3 3 3 0 Resistin Utp8 PF10395.9 ETO34513.1 - 0.59 8.6 4.7 1.6 7.1 0.3 3.0 1 1 2 4 4 4 0 Utp8 family MiaE PF06175.11 ETO34515.1 - 0.0018 18.0 0.1 0.0021 17.7 0.1 1.2 1 0 0 1 1 1 1 tRNA-(MS[2]IO[6]A)-hydroxylase (MiaE) DUF2666 PF10869.8 ETO34515.1 - 0.049 13.8 5.7 1.5 9.0 0.2 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF2666) RRM_1 PF00076.22 ETO34516.1 - 0.013 15.3 0.3 1.5 8.7 0.0 3.0 2 1 1 3 3 3 0 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) DnaJ PF00226.31 ETO34516.1 - 0.06 13.5 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 DnaJ domain DSPc PF00782.20 ETO34517.1 - 1.4e-07 31.4 1.8 0.00018 21.3 0.2 2.4 2 0 0 2 2 2 2 Dual specificity phosphatase, catalytic domain DUF2552 PF10827.8 ETO34518.1 - 0.047 13.9 0.0 0.094 12.9 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2552) Tweety PF04906.13 ETO34518.1 - 0.051 12.2 0.0 0.063 11.9 0.0 1.0 1 0 0 1 1 1 0 Tweety WD40 PF00400.32 ETO34519.1 - 4e-64 211.0 14.5 5e-10 39.8 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34519.1 - 4e-29 100.8 1.3 2.6e-05 24.4 0.0 6.4 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34519.1 - 9.4e-16 58.0 3.4 6.8e-05 22.3 0.0 4.0 1 1 3 4 4 4 3 WD40-like domain Ge1_WD40 PF16529.5 ETO34519.1 - 6.5e-13 48.3 0.1 0.016 14.2 0.0 5.7 1 1 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO34519.1 - 8.4e-11 42.1 0.1 6.5e-05 22.9 0.0 3.1 1 1 3 4 4 4 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO34519.1 - 3e-08 32.8 0.0 0.82 8.2 0.0 4.5 3 2 1 4 4 4 3 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO34519.1 - 3.1e-06 27.3 1.2 1.6 8.8 0.0 4.4 3 1 2 5 5 5 2 Family of unknown function (DUF5570) PD40 PF07676.12 ETO34519.1 - 1.1e-05 25.2 5.5 3 7.9 0.0 5.7 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO34519.1 - 4.3e-05 23.2 0.0 4.1 7.5 0.1 5.3 6 0 0 6 6 6 2 PQQ enzyme repeat PQQ_2 PF13360.6 ETO34519.1 - 0.00052 19.7 0.0 0.11 12.0 0.0 3.0 1 1 0 1 1 1 1 PQQ-like domain BBS2_Mid PF14783.6 ETO34519.1 - 0.0023 17.9 2.9 0.82 9.7 0.0 4.5 2 2 3 5 5 5 1 Ciliary BBSome complex subunit 2, middle region Cytochrom_D1 PF02239.16 ETO34519.1 - 0.01 14.4 0.3 5.4 5.4 0.0 3.0 1 1 3 4 4 4 0 Cytochrome D1 heme domain Me-amine-dh_H PF06433.11 ETO34519.1 - 0.013 14.3 0.0 2.5 6.9 0.0 2.9 3 0 0 3 3 3 0 Methylamine dehydrogenase heavy chain (MADH) Colicin_Ia PF11504.8 ETO34519.1 - 1.2 9.3 4.2 1.9e+02 2.3 0.0 4.6 6 0 0 6 6 5 0 Colicin Ia Proteasome_A_N PF10584.9 ETO34519.1 - 6.5 6.5 5.9 7.1 6.4 0.0 3.1 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature DUF3490 PF11995.8 ETO34520.1 - 0.019 14.8 1.6 0.024 14.5 1.4 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF3490) Cdc13_OB2 PF18691.1 ETO34521.1 - 0.00067 19.7 7.7 0.0016 18.4 4.3 2.2 1 1 1 2 2 2 1 Cell division control protein 13, OB2 domain RE_SacI PF09566.10 ETO34521.1 - 0.0079 16.0 2.0 0.019 14.8 2.0 1.6 1 1 0 1 1 1 1 SacI restriction endonuclease DUF4738 PF15889.5 ETO34521.1 - 0.034 14.0 0.8 0.062 13.1 0.4 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4738) Pkinase PF00069.25 ETO34522.1 - 3.9e-24 85.5 0.0 4.7e-24 85.2 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34522.1 - 1.5e-10 40.8 0.0 2e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO34522.1 - 0.038 12.7 0.0 0.049 12.4 0.0 1.1 1 0 0 1 1 1 0 Fungal protein kinase Dis3l2_C_term PF17877.1 ETO34522.1 - 0.17 12.2 0.1 1.4 9.3 0.0 2.1 2 0 0 2 2 2 0 DIS3-like exonuclease 2 C terminal Kdo PF06293.14 ETO34522.1 - 0.35 10.2 0.8 0.49 9.7 0.8 1.2 1 0 0 1 1 1 0 Lipopolysaccharide kinase (Kdo/WaaP) family Complex1_LYR PF05347.15 ETO34524.1 - 0.021 14.9 0.3 0.036 14.1 0.3 1.4 1 0 0 1 1 1 0 Complex 1 protein (LYR family) DUF4199 PF13858.6 ETO34524.1 - 0.1 13.0 4.2 0.54 10.7 0.5 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF4199) FHA PF00498.26 ETO34525.1 - 1.2e-14 54.3 0.1 3.2e-14 53.0 0.1 1.8 1 0 0 1 1 1 1 FHA domain Yop-YscD_cpl PF16697.5 ETO34525.1 - 3.6e-13 49.6 0.0 7.9e-13 48.5 0.0 1.5 1 0 0 1 1 1 1 Inner membrane component of T3SS, cytoplasmic domain RGS PF00615.19 ETO34525.1 - 5.6e-08 33.1 8.9 2e-07 31.3 8.9 1.9 1 1 0 1 1 1 1 Regulator of G protein signaling domain DEK_C PF08766.11 ETO34525.1 - 0.032 14.1 1.1 3.6 7.6 0.2 3.0 2 0 0 2 2 2 0 DEK C terminal domain Trp_repressor PF01371.19 ETO34525.1 - 0.069 13.3 0.7 4.7 7.4 0.0 3.1 3 0 0 3 3 3 0 Trp repressor protein ResIII PF04851.15 ETO34525.1 - 0.076 13.0 0.2 0.076 13.0 0.2 2.5 1 1 2 3 3 3 0 Type III restriction enzyme, res subunit WD40 PF00400.32 ETO34526.1 - 4.7e-57 188.6 18.5 2.2e-07 31.4 0.2 8.4 8 0 0 8 8 8 8 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34526.1 - 1.3e-15 57.5 4.8 0.042 14.1 0.0 6.5 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34526.1 - 6.8e-09 35.1 4.9 0.13 11.2 0.0 5.8 2 1 3 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO34526.1 - 1.7e-08 34.0 2.4 3.7e-08 32.9 2.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) WD40_like PF17005.5 ETO34526.1 - 4.5e-05 22.9 16.2 0.012 14.9 0.4 4.5 3 1 2 5 5 5 4 WD40-like domain Pentapeptide_4 PF13599.6 ETO34526.1 - 5e-05 23.4 0.1 0.00016 21.8 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO34526.1 - 0.00043 20.4 0.1 0.0011 19.0 0.1 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO34526.1 - 0.00075 18.1 0.5 0.077 11.5 0.2 2.7 2 1 1 3 3 3 1 Cytochrome D1 heme domain Str_synth PF03088.16 ETO34526.1 - 0.0018 18.4 0.8 21 5.3 0.0 4.9 4 1 1 5 5 5 0 Strictosidine synthase DUF3475 PF11961.8 ETO34526.1 - 0.17 12.0 0.6 14 5.8 0.0 3.6 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) WD40 PF00400.32 ETO34527.1 - 1.7e-09 38.1 2.9 0.00093 20.0 0.0 3.6 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34527.1 - 0.00014 22.1 0.0 0.27 11.6 0.0 3.4 1 1 3 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34527.1 - 0.0002 20.4 0.7 0.28 10.1 0.0 2.9 2 2 0 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO34527.1 - 0.00081 18.8 0.9 0.5 9.7 0.1 2.2 1 1 0 2 2 2 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO34527.1 - 0.0038 17.1 2.3 3.4 7.7 0.0 3.6 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO34527.1 - 0.035 13.7 0.0 0.32 10.5 0.0 2.0 1 1 1 2 2 2 0 PQQ-like domain DUF2256 PF10013.9 ETO34528.1 - 0.52 10.5 3.0 0.98 9.6 0.5 2.3 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2256) EIIBC-GUT_N PF03612.14 ETO34532.1 - 0.72 9.6 3.1 0.91 9.2 3.1 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus WD40 PF00400.32 ETO34533.1 - 2.3e-34 116.8 22.6 8.8e-06 26.4 0.5 6.8 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34533.1 - 5.3e-11 42.7 1.1 0.04 14.2 0.0 6.2 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34533.1 - 7.7e-08 31.4 4.9 1.1 7.8 0.0 5.2 2 2 3 5 5 5 4 Nucleoporin Nup120/160 U-box PF04564.15 ETO34534.1 - 1.1e-10 41.5 0.7 5.1e-10 39.4 0.1 2.6 2 1 0 2 2 2 1 U-box domain Ac76 PF05814.11 ETO34534.1 - 2.3 8.3 7.7 0.17 11.9 1.9 2.1 2 0 0 2 2 2 0 Orf76 (Ac76) Cbl_N2 PF02761.14 ETO34534.1 - 2.9 8.7 7.6 1.2 9.9 1.1 2.9 2 0 0 2 2 2 0 CBL proto-oncogene N-terminus, EF hand-like domain PulA_N1 PF17999.1 ETO34535.1 - 0.18 12.6 4.4 1.8 9.4 0.2 3.4 3 0 0 3 3 3 0 Pullulanase N1-terminal domain Pkinase PF00069.25 ETO34536.1 - 1.9e-21 76.7 0.0 2.2e-21 76.4 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34536.1 - 4.3e-07 29.5 0.0 4.7e-07 29.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Borrelia_P83 PF05262.11 ETO34536.1 - 0.16 10.5 0.0 0.19 10.2 0.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein zf-C3HC4_3 PF13920.6 ETO34538.1 - 0.0051 16.6 8.5 0.0051 16.6 8.5 3.2 4 1 1 5 5 5 1 Zinc finger, C3HC4 type (RING finger) Tudor-knot PF11717.8 ETO34538.1 - 0.02 14.8 0.5 0.059 13.3 0.5 1.8 1 0 0 1 1 1 0 RNA binding activity-knot of a chromodomain GTP_EFTU_D3 PF03143.17 ETO34539.1 - 1.1e-11 45.0 0.1 2.8e-11 43.7 0.0 1.6 2 0 0 2 2 2 1 Elongation factor Tu C-terminal domain GTP_EFTU_D2 PF03144.25 ETO34539.1 - 6.2e-06 26.5 0.1 1e-05 25.8 0.1 1.3 1 0 0 1 1 1 1 Elongation factor Tu domain 2 GTP_EFTU PF00009.27 ETO34539.1 - 0.0074 15.8 0.0 0.008 15.7 0.0 1.2 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Myosin_TH1 PF06017.13 ETO34540.1 - 2.8e-17 63.0 4.6 3.9e-17 62.5 4.6 1.2 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding hSac2 PF12456.8 ETO34540.1 - 0.0022 17.7 0.2 0.0022 17.7 0.2 1.8 2 0 0 2 2 2 1 Inositol phosphatase HPD PF05044.12 ETO34540.1 - 0.098 12.5 3.1 0.1 12.5 0.5 2.2 3 1 0 3 3 3 0 Homeo-prospero domain DUF4247 PF14042.6 ETO34540.1 - 0.11 13.2 0.1 0.14 12.9 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4247) RabGAP-TBC PF00566.18 ETO34542.1 - 3.4e-31 108.6 18.7 2.7e-19 69.7 2.5 3.9 3 1 0 3 3 3 2 Rab-GTPase-TBC domain Pkinase PF00069.25 ETO34543.1 - 2.4e-28 99.2 0.2 2e-27 96.2 0.0 1.9 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34543.1 - 1.8e-11 43.9 0.0 7.8e-11 41.7 0.0 1.8 1 1 0 1 1 1 1 Protein tyrosine kinase RIO1 PF01163.22 ETO34543.1 - 0.0006 19.5 0.3 0.0011 18.6 0.1 1.5 2 0 0 2 2 2 1 RIO1 family Kdo PF06293.14 ETO34543.1 - 0.00068 19.1 0.0 0.0014 18.1 0.0 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO34543.1 - 0.0052 16.7 0.0 0.012 15.5 0.0 1.6 1 1 1 2 2 2 1 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO34543.1 - 0.0059 16.0 0.0 0.012 15.0 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Adipogenin PF15202.6 ETO34543.1 - 1.3 9.2 5.3 2.7 8.1 5.3 1.5 1 0 0 1 1 1 0 Adipogenin MitMem_reg PF13012.6 ETO34544.1 - 0.055 13.9 7.3 2.8 8.4 0.1 2.4 1 1 1 2 2 2 0 Maintenance of mitochondrial structure and function CUE PF02845.16 ETO34544.1 - 0.099 12.4 0.1 0.3 10.8 0.1 1.9 1 0 0 1 1 1 0 CUE domain DUF4874 PF16173.5 ETO34544.1 - 0.12 12.1 5.2 1.5 8.4 2.7 2.6 2 0 0 2 2 2 0 Domain of unknown function (DUF4874) HisKA PF00512.25 ETO34545.1 - 0.032 14.2 0.6 0.12 12.4 0.2 2.0 2 0 0 2 2 2 0 His Kinase A (phospho-acceptor) domain YlbE PF14003.6 ETO34545.1 - 6.5 7.3 7.5 70 4.0 1.3 4.0 3 1 0 3 3 3 0 YlbE-like protein WD40 PF00400.32 ETO34546.1 - 3.6e-07 30.8 7.4 2e-05 25.2 1.0 3.4 3 2 0 3 3 3 2 WD domain, G-beta repeat ICMT PF04140.14 ETO34546.1 - 0.0043 17.4 0.4 0.0081 16.6 0.4 1.4 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family DUF2196 PF09962.9 ETO34547.1 - 0.052 13.5 0.0 0.1 12.6 0.0 1.6 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2196) zf-C4H2 PF10146.9 ETO34547.1 - 1.3 9.3 13.0 1.4 9.1 12.5 1.2 1 1 0 1 1 1 0 Zinc finger-containing protein STAT_int PF02865.17 ETO34548.1 - 0.033 14.6 2.7 0.1 13.1 2.7 1.8 1 0 0 1 1 1 0 STAT protein, protein interaction domain CREPT PF16566.5 ETO34548.1 - 0.16 12.1 7.0 0.48 10.6 7.0 1.7 1 0 0 1 1 1 0 Cell-cycle alteration and expression-elevated protein in tumour Occludin_ELL PF07303.13 ETO34548.1 - 0.81 10.4 8.0 2.3 9.0 8.0 1.7 1 0 0 1 1 1 0 Occludin homology domain 14-3-3 PF00244.20 ETO34549.1 - 2.6e-59 200.4 8.2 3.9e-59 199.9 8.2 1.3 1 0 0 1 1 1 1 14-3-3 protein YL1 PF05764.13 ETO34549.1 - 0.0035 17.5 5.9 0.0055 16.8 5.9 1.3 1 0 0 1 1 1 1 YL1 nuclear protein TLP-20 PF06088.11 ETO34549.1 - 0.025 14.5 0.3 0.044 13.7 0.3 1.5 1 0 0 1 1 1 0 Nucleopolyhedrovirus telokin-like protein-20 (TLP20) Sigma70_ner PF04546.13 ETO34549.1 - 0.035 14.0 6.5 0.055 13.3 2.7 2.2 2 0 0 2 2 2 0 Sigma-70, non-essential region CelTOS PF18659.1 ETO34549.1 - 0.048 14.1 0.0 0.12 12.8 0.0 1.6 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites DNA_pol_phi PF04931.13 ETO34549.1 - 4.7 5.2 16.4 3.1 5.8 14.0 1.8 2 1 0 2 2 2 0 DNA polymerase phi DUF4637 PF15470.6 ETO34549.1 - 5 6.8 8.7 10 5.8 8.7 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) DUF5090 PF17009.5 ETO34550.1 - 0.15 12.0 9.4 0.25 11.3 9.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF5090) G-patch_2 PF12656.7 ETO34552.1 - 0.00011 22.1 1.3 0.00019 21.4 0.5 1.7 2 0 0 2 2 2 1 G-patch domain FtsK_alpha PF17854.1 ETO34554.1 - 0.21 11.7 1.1 0.42 10.8 0.2 2.1 2 1 0 2 2 2 0 FtsK alpha domain SSP160 PF06933.11 ETO34558.1 - 1.1 7.4 14.1 1.5 6.9 14.1 1.1 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Secretin_N_2 PF07655.13 ETO34558.1 - 1.2 9.8 19.6 1.1 9.8 16.6 2.6 2 0 0 2 2 2 0 Secretin N-terminal domain DUF3446 PF11928.8 ETO34558.1 - 3.4 8.0 22.7 1.2 9.4 18.4 2.4 2 0 0 2 2 2 0 Early growth response N-terminal domain Chorion_2 PF03964.15 ETO34558.1 - 5.3 7.9 13.7 0.49 11.3 8.3 2.0 2 0 0 2 2 2 0 Chorion family 2 dDENN PF03455.19 ETO34559.1 - 0.00094 19.1 0.1 0.0017 18.3 0.1 1.5 1 0 0 1 1 1 1 dDENN domain Cation_ATPase_C PF00689.21 ETO34560.1 - 4.2e-43 147.2 8.5 4.2e-43 147.2 8.5 1.4 2 0 0 2 2 2 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETO34560.1 - 0.00095 19.5 0.0 0.0016 18.8 0.0 1.3 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETO34560.1 - 0.008 16.0 0.4 0.012 15.4 0.4 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase WD40 PF00400.32 ETO34561.1 - 2.8e-39 132.4 22.9 2.3e-05 25.1 0.2 7.9 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34561.1 - 6.6e-13 48.8 4.9 0.012 15.8 0.1 5.9 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34561.1 - 2.1e-09 36.6 11.2 0.042 12.5 0.2 5.9 1 1 4 5 5 5 5 Nucleoporin Nup120/160 HARP PF07443.13 ETO34561.1 - 0.011 15.4 1.8 6.8 6.4 0.0 4.9 6 0 0 6 6 6 0 HepA-related protein (HARP) Peptidase_C9 PF01707.16 ETO34561.1 - 0.022 14.3 0.6 3.2 7.3 0.0 3.6 3 2 0 3 3 3 0 Peptidase family C9 AAA PF00004.29 ETO34562.1 - 2.1e-21 76.7 0.2 3.5e-21 76.0 0.2 1.4 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) Vps4_C PF09336.10 ETO34562.1 - 3e-08 33.6 0.1 9.7e-08 31.9 0.0 1.9 2 0 0 2 2 2 1 Vps4 C terminal oligomerisation domain AAA_lid_3 PF17862.1 ETO34562.1 - 7.4e-08 32.1 0.0 4.3e-07 29.6 0.0 2.1 2 0 0 2 2 2 1 AAA+ lid domain PELOTA_1 PF15608.6 ETO34562.1 - 0.15 12.0 0.1 5.5 7.0 0.0 2.3 2 0 0 2 2 2 0 PELOTA RNA binding domain Bin3 PF06859.12 ETO34564.1 - 0.42 11.3 5.4 0.52 11.0 5.4 1.1 1 0 0 1 1 1 0 Bicoid-interacting protein 3 (Bin3) ANTH PF07651.16 ETO34567.1 - 0.0019 17.3 0.9 0.002 17.2 0.9 1.0 1 0 0 1 1 1 1 ANTH domain DUF4834 PF16118.5 ETO34567.1 - 0.0038 18.2 0.9 0.005 17.8 0.9 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Cadherin_C_2 PF16492.5 ETO34567.1 - 0.0064 17.2 0.5 0.0095 16.7 0.4 1.3 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal OSTbeta PF15048.6 ETO34567.1 - 0.0085 16.2 1.4 0.01 16.0 1.4 1.1 1 0 0 1 1 1 1 Organic solute transporter subunit beta protein S_4TM PF18159.1 ETO34567.1 - 0.011 15.0 1.0 0.012 14.9 1.0 1.0 1 0 0 1 1 1 0 SMODS-associating 4TM effector domain OATP PF03137.20 ETO34567.1 - 0.013 13.8 0.1 0.014 13.7 0.1 1.0 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family TMEM51 PF15345.6 ETO34567.1 - 0.03 14.2 0.0 0.035 13.9 0.0 1.0 1 0 0 1 1 1 0 Transmembrane protein 51 Pex2_Pex12 PF04757.14 ETO34567.1 - 0.034 13.7 0.4 0.045 13.3 0.4 1.2 1 0 0 1 1 1 0 Pex2 / Pex12 amino terminal region Folate_carrier PF01770.18 ETO34567.1 - 0.036 12.8 0.6 0.037 12.8 0.6 1.0 1 0 0 1 1 1 0 Reduced folate carrier O-antigen_lig PF13425.6 ETO34567.1 - 0.046 12.5 2.3 0.047 12.5 2.3 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein Ion_trans PF00520.31 ETO34567.1 - 0.055 12.7 1.8 0.067 12.4 1.8 1.2 1 0 0 1 1 1 0 Ion transport protein RIC3 PF15361.6 ETO34567.1 - 0.058 13.8 0.3 0.083 13.3 0.3 1.2 1 0 0 1 1 1 0 Resistance to inhibitors of cholinesterase homologue 3 Ctr PF04145.15 ETO34567.1 - 0.065 13.9 0.2 0.075 13.7 0.2 1.1 1 0 0 1 1 1 0 Ctr copper transporter family CSG2 PF16965.5 ETO34567.1 - 0.093 11.7 1.0 0.09 11.7 1.0 1.0 1 0 0 1 1 1 0 Ceramide synthase regulator Tmem26 PF09772.9 ETO34567.1 - 0.11 11.8 0.1 0.13 11.6 0.1 1.1 1 0 0 1 1 1 0 Transmembrane protein 26 Zip PF02535.22 ETO34567.1 - 0.13 11.4 0.1 0.14 11.3 0.1 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter WBP-1 PF11669.8 ETO34567.1 - 0.15 12.8 0.0 0.17 12.5 0.0 1.1 1 0 0 1 1 1 0 WW domain-binding protein 1 Menin PF05053.13 ETO34567.1 - 0.19 10.0 5.9 0.19 10.1 5.9 1.0 1 0 0 1 1 1 0 Menin Secretin_N_2 PF07655.13 ETO34567.1 - 0.42 11.2 13.9 0.56 10.8 13.9 1.2 1 0 0 1 1 1 0 Secretin N-terminal domain ATP-synt_8 PF00895.20 ETO34567.1 - 2.7 8.5 5.5 12 6.4 5.5 2.0 1 1 0 1 1 1 0 ATP synthase protein 8 ETRAMP PF09716.10 ETO34567.1 - 5.1 7.2 12.3 8.7 6.5 12.3 1.5 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) DUF2971 PF11185.8 ETO34568.1 - 0.00088 20.4 0.2 0.00088 20.4 0.2 3.0 2 1 0 2 2 2 1 Protein of unknown function (DUF2971) EcoR124_C PF12008.8 ETO34569.1 - 6.7e-67 225.9 18.8 6.7e-67 225.9 18.8 4.3 5 1 0 5 5 5 1 Type I restriction and modification enzyme - subunit R C terminal HSDR_N PF04313.14 ETO34569.1 - 9.8e-43 146.4 11.2 9.8e-43 146.4 11.2 2.7 2 0 0 2 2 2 1 Type I restriction enzyme R protein N terminus (HSDR_N) SWI2_SNF2 PF18766.1 ETO34569.1 - 1.5e-41 142.5 2.1 1.5e-41 142.5 2.1 2.1 2 0 0 2 2 2 1 SWI2/SNF2 ATPase ResIII PF04851.15 ETO34569.1 - 3.9e-19 69.3 1.6 3.9e-19 69.3 1.6 4.5 4 1 0 4 4 4 1 Type III restriction enzyme, res subunit DEAD PF00270.29 ETO34569.1 - 3.2e-06 27.0 0.1 1e-05 25.4 0.0 1.9 2 0 0 2 2 2 1 DEAD/DEAH box helicase HHH_4 PF14490.6 ETO34569.1 - 0.025 14.6 1.6 8.7 6.4 0.1 3.2 3 0 0 3 3 3 0 Helix-hairpin-helix containing domain FBA_2 PF07735.17 ETO34569.1 - 0.15 12.2 3.3 1 9.5 3.3 2.6 1 0 0 1 1 1 0 F-box associated N6_Mtase PF02384.16 ETO34570.1 - 1.1e-90 304.1 5.6 1.3e-45 156.0 0.1 2.8 2 1 1 3 3 3 2 N-6 DNA Methylase Virulence_RhuM PF13310.6 ETO34570.1 - 1.3e-89 299.8 14.8 7.7e-89 297.3 14.8 2.1 1 1 0 1 1 1 1 Virulence protein RhuM family Methylase_S PF01420.19 ETO34570.1 - 2e-19 70.4 1.1 2e-19 70.4 1.1 2.2 2 0 0 2 2 2 1 Type I restriction modification DNA specificity domain Methyltransf_31 PF13847.6 ETO34570.1 - 0.0018 18.1 1.0 0.006 16.4 0.0 2.4 3 0 0 3 3 3 1 Methyltransferase domain AviRa PF11599.8 ETO34570.1 - 0.036 13.5 0.0 0.35 10.3 0.0 2.4 2 0 0 2 2 2 0 RRNA methyltransferase AviRa UPF0020 PF01170.18 ETO34570.1 - 0.11 12.2 0.3 1.5 8.5 0.0 2.7 3 0 0 3 3 3 0 Putative RNA methylase family UPF0020 DUF4238 PF14022.6 ETO34571.1 - 7.2e-12 45.4 7.1 1.3e-11 44.5 7.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF4238) DUF5621 PF18532.1 ETO34571.1 - 0.12 12.2 10.0 1.2 9.0 0.1 3.0 1 1 1 3 3 3 0 Domain of unknown function (DUF5621) FtsJ PF01728.19 ETO34572.1 - 9.8e-55 185.4 0.0 1.2e-54 185.1 0.0 1.1 1 0 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 ETO34572.1 - 0.0002 21.2 0.7 0.029 14.2 0.0 2.6 3 0 0 3 3 3 2 Methyltransferase domain Methyltransf_23 PF13489.6 ETO34572.1 - 0.0011 18.8 0.0 0.0015 18.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO34572.1 - 0.013 16.2 0.0 0.057 14.1 0.0 2.2 1 1 0 1 1 1 0 Methyltransferase domain ARL2_Bind_BART PF11527.8 ETO34574.1 - 0.98 9.5 5.6 8.4 6.5 0.0 3.9 3 1 0 4 4 4 0 The ARF-like 2 binding protein BART Cas_Csy4 PF09618.10 ETO34575.1 - 5.9e-47 160.2 0.4 9.3e-47 159.5 0.4 1.3 1 0 0 1 1 1 1 CRISPR-associated protein (Cas_Csy4) AARP2CN PF08142.12 ETO34576.1 - 0.028 14.5 0.2 3.4 7.8 0.0 2.4 2 0 0 2 2 2 0 AARP2CN (NUC121) domain MecA_N PF05223.11 ETO34576.1 - 0.036 14.3 0.0 0.1 12.9 0.0 1.8 1 0 0 1 1 1 0 NTF2-like N-terminal transpeptidase domain DEAD PF00270.29 ETO34577.1 - 1.2e-08 34.9 0.1 3e-08 33.6 0.1 1.7 1 0 0 1 1 1 1 DEAD/DEAH box helicase ResIII PF04851.15 ETO34577.1 - 1.8e-08 34.6 0.2 1.8e-08 34.6 0.2 3.0 3 0 0 3 3 3 1 Type III restriction enzyme, res subunit HD_6 PF18019.1 ETO34577.1 - 6.4e-06 26.4 0.4 1.4e-05 25.3 0.4 1.5 1 0 0 1 1 1 1 HD domain Helicase_C PF00271.31 ETO34577.1 - 0.00083 19.7 0.8 0.0043 17.4 0.0 2.7 3 0 0 3 3 2 1 Helicase conserved C-terminal domain Erf4 PF10256.9 ETO34577.1 - 0.0051 16.9 1.0 9.8 6.3 0.0 4.1 4 0 0 4 4 4 1 Golgin subfamily A member 7/ERF4 family SNF2_N PF00176.23 ETO34577.1 - 0.0061 15.3 0.0 0.017 13.9 0.0 1.6 1 1 0 1 1 1 1 SNF2 family N-terminal domain PhoH PF02562.16 ETO34577.1 - 0.013 15.0 0.1 0.052 13.0 0.0 2.0 2 0 0 2 2 2 0 PhoH-like protein ATPase_2 PF01637.18 ETO34577.1 - 0.052 13.5 0.1 0.052 13.5 0.1 2.5 3 0 0 3 3 3 0 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO34577.1 - 0.064 13.6 0.0 0.21 12.0 0.0 1.9 1 1 0 1 1 1 0 AAA ATPase domain NACHT PF05729.12 ETO34577.1 - 0.14 12.1 0.0 0.39 10.6 0.0 1.9 1 1 0 1 1 1 0 NACHT domain AAA PF00004.29 ETO34577.1 - 0.15 12.4 0.1 0.86 10.0 0.1 2.4 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) SF-assemblin PF06705.11 ETO34577.1 - 1.7 7.9 10.9 0.4 10.0 1.4 3.1 3 0 0 3 3 3 0 SF-assemblin/beta giardin DUF2400 PF09674.10 ETO34577.1 - 2.4 8.1 7.0 13 5.7 0.3 3.5 2 2 1 3 3 3 0 Protein of unknown function (DUF2400) Zip PF02535.22 ETO34578.1 - 0.00024 20.4 0.4 0.00028 20.2 0.4 1.0 1 0 0 1 1 1 1 ZIP Zinc transporter UPF0242 PF06785.11 ETO34578.1 - 0.0031 17.6 1.4 0.0037 17.4 1.4 1.1 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus SID-1_RNA_chan PF13965.6 ETO34578.1 - 0.0053 15.2 1.4 0.006 15.1 1.4 1.0 1 0 0 1 1 1 1 dsRNA-gated channel SID-1 Ctr PF04145.15 ETO34578.1 - 0.0055 17.3 1.4 0.0074 16.9 1.4 1.4 1 0 0 1 1 1 1 Ctr copper transporter family Tmemb_9 PF05434.11 ETO34578.1 - 0.011 15.6 2.2 0.014 15.3 1.6 1.5 1 1 0 1 1 1 0 TMEM9 Connexin PF00029.19 ETO34578.1 - 0.039 13.7 0.5 0.049 13.4 0.5 1.2 1 0 0 1 1 1 0 Connexin Menin PF05053.13 ETO34578.1 - 0.11 10.9 10.6 0.12 10.7 10.6 1.1 1 0 0 1 1 1 0 Menin Folate_carrier PF01770.18 ETO34578.1 - 0.27 9.9 2.2 0.37 9.5 2.2 1.3 1 0 0 1 1 1 0 Reduced folate carrier NST1 PF13945.6 ETO34578.1 - 2.5 8.2 22.4 3.3 7.8 22.4 1.1 1 0 0 1 1 1 0 Salt tolerance down-regulator MDFI PF15316.6 ETO34578.1 - 3.6 7.7 7.2 5 7.2 7.2 1.2 1 0 0 1 1 1 0 MyoD family inhibitor Apc15p PF05841.11 ETO34578.1 - 7.6 7.4 16.6 11 6.8 16.6 1.2 1 0 0 1 1 1 0 Apc15p protein ALMT PF11744.8 ETO34578.1 - 9.8 4.9 9.6 12 4.6 9.6 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF600 PF04634.12 ETO34579.1 - 0.0045 17.0 2.0 0.0049 16.9 2.0 1.1 1 0 0 1 1 1 1 Protein of unknown function, DUF600 Gamma_PGA_hydro PF05908.11 ETO34579.1 - 0.035 13.5 0.1 0.038 13.4 0.1 1.1 1 0 0 1 1 1 0 Poly-gamma-glutamate hydrolase Kelch_1 PF01344.25 ETO34580.1 - 9e-05 22.0 2.4 0.017 14.7 0.6 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_2 PF07646.15 ETO34580.1 - 0.00028 20.7 5.5 0.6 10.2 0.8 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO34580.1 - 0.00063 19.7 5.6 0.4 10.7 1.6 3.9 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO34580.1 - 0.0035 17.3 0.5 0.037 14.0 0.6 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO34580.1 - 0.004 17.4 3.0 3.1 8.2 0.0 3.8 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO34580.1 - 0.048 14.0 0.7 0.32 11.3 0.3 2.7 4 0 0 4 4 4 0 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO34580.1 - 0.12 11.5 0.4 0.65 9.1 0.2 2.0 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase SPRY PF00622.28 ETO34581.1 - 3.5e-07 30.3 0.0 6e-07 29.6 0.0 1.4 1 0 0 1 1 1 1 SPRY domain YPEB PF14620.6 ETO34581.1 - 0.029 13.7 0.7 0.044 13.1 0.7 1.3 1 1 0 1 1 1 0 YpeB sporulation WD40 PF00400.32 ETO34582.1 - 3e-07 31.0 1.0 0.0024 18.7 0.0 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34582.1 - 0.033 14.5 0.1 0.87 9.9 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain D123 PF07065.14 ETO34583.1 - 2.8e-10 39.9 10.7 1.5e-08 34.2 0.1 3.2 1 1 1 3 3 3 3 D123 MIF4G_like PF09088.11 ETO34583.1 - 0.058 13.2 0.0 0.13 12.0 0.0 1.7 1 0 0 1 1 1 0 MIF4G like TIP49 PF06068.13 ETO34584.1 - 2.6e-35 122.3 0.9 3.4e-35 121.9 0.9 1.1 1 0 0 1 1 1 1 TIP49 P-loop domain SAP18 PF06487.12 ETO34585.1 - 1.1 9.4 8.1 0.74 10.0 0.3 2.8 2 0 0 2 2 2 0 Sin3 associated polypeptide p18 (SAP18) Nucleoside_tran PF01733.18 ETO34585.1 - 3.4 6.9 5.8 3 7.1 0.3 2.2 2 0 0 2 2 2 0 Nucleoside transporter Pkinase PF00069.25 ETO34586.1 - 2.3e-29 102.5 0.1 1.5e-28 99.9 0.1 2.0 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34586.1 - 9e-23 80.9 0.0 6.3e-19 68.3 0.0 2.1 2 0 0 2 2 2 2 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO34586.1 - 6.7e-06 25.3 0.2 5.9e-05 22.2 0.1 2.0 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ETO34586.1 - 0.043 13.2 0.2 0.25 10.7 0.1 2.0 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO34586.1 - 0.096 12.6 0.0 0.31 10.9 0.0 1.7 2 0 0 2 2 2 0 Phosphotransferase enzyme family ALMT PF11744.8 ETO34587.1 - 0.021 13.7 2.4 0.024 13.5 2.4 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter IL34 PF15036.6 ETO34587.1 - 0.044 13.8 0.6 0.072 13.1 0.6 1.6 1 1 0 1 1 1 0 Interleukin 34 DUF4200 PF13863.6 ETO34587.1 - 0.17 12.3 10.5 0.26 11.7 10.5 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) PhnA_Zn_Ribbon PF08274.12 ETO34587.1 - 0.19 11.7 1.5 0.28 11.2 0.4 1.9 2 0 0 2 2 2 0 PhnA Zinc-Ribbon SWIB PF02201.18 ETO34587.1 - 7.4 6.5 10.0 0.97 9.4 3.0 2.7 2 1 0 2 2 2 0 SWIB/MDM2 domain Kelch_1 PF01344.25 ETO34588.1 - 4.3e-05 23.0 0.8 0.015 14.8 0.0 3.5 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO34588.1 - 5.5e-05 23.1 1.1 0.003 17.5 0.0 3.5 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO34588.1 - 0.00061 20.0 0.0 0.0099 16.1 0.0 2.8 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO34588.1 - 0.035 14.4 5.2 1 9.7 0.0 4.1 4 1 1 5 5 5 0 Kelch motif PUB PF09409.10 ETO34589.1 - 0.32 11.0 6.9 0.088 12.8 2.2 2.6 2 1 0 2 2 2 0 PUB domain WD40 PF00400.32 ETO34591.1 - 6.6e-38 128.0 32.7 5e-07 30.3 0.2 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34591.1 - 5.8e-09 36.1 4.6 0.058 13.7 0.0 5.6 4 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34591.1 - 6.8e-08 31.6 9.3 0.013 14.2 0.2 4.4 1 1 3 4 4 4 4 Nucleoporin Nup120/160 Read-through PF16814.5 ETO34591.1 - 0.35 10.7 5.8 0.22 11.3 0.2 2.4 2 1 0 2 2 2 0 Read-through domain NACHT PF05729.12 ETO34593.1 - 4.4e-09 36.5 0.0 1e-08 35.3 0.0 1.7 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO34593.1 - 0.00011 22.5 0.2 0.0014 18.9 0.1 2.9 2 1 0 2 2 2 1 AAA domain AAA PF00004.29 ETO34593.1 - 0.0029 18.0 0.3 0.028 14.8 0.0 2.6 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO34593.1 - 0.003 18.1 0.0 0.003 18.1 0.0 3.5 4 0 0 4 4 4 1 AAA domain ATP_bind_2 PF03668.15 ETO34593.1 - 0.0061 15.9 0.0 3.4 6.9 0.0 2.7 2 0 0 2 2 2 2 P-loop ATPase protein family TsaE PF02367.17 ETO34593.1 - 0.0071 16.3 0.1 0.027 14.4 0.0 2.0 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_33 PF13671.6 ETO34593.1 - 0.067 13.4 0.0 0.25 11.5 0.0 2.0 2 0 0 2 2 2 0 AAA domain RNA_helicase PF00910.22 ETO34593.1 - 0.95 9.9 5.0 2 8.8 0.1 3.7 3 1 0 3 3 3 0 RNA helicase ATP-synt_ab_N PF02874.23 ETO34594.1 - 9e-06 26.1 0.0 1.4e-05 25.5 0.0 1.2 1 0 0 1 1 1 1 ATP synthase alpha/beta family, beta-barrel domain A2L_zn_ribbon PF08792.10 ETO34595.1 - 0.075 12.8 1.7 0.2 11.4 0.1 2.4 3 0 0 3 3 3 0 A2L zinc ribbon domain Tat PF00539.18 ETO34595.1 - 0.091 12.9 0.3 1 9.6 0.1 2.2 2 0 0 2 2 2 0 Transactivating regulatory protein (Tat) DNA_ligase_ZBD PF03119.16 ETO34595.1 - 0.26 11.3 1.4 14 5.8 0.1 2.6 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain WD40 PF00400.32 ETO34597.1 - 6.5e-57 188.2 12.8 3.2e-09 37.3 0.1 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34597.1 - 3e-23 81.9 0.6 0.00094 19.4 0.0 6.0 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34597.1 - 1.7e-12 47.0 0.3 0.065 12.2 0.0 5.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34597.1 - 1.9e-11 43.9 0.0 0.00021 20.7 0.0 3.4 1 1 2 4 4 4 2 WD40-like domain eIF2A PF08662.11 ETO34597.1 - 8.7e-11 42.1 0.1 0.0095 15.8 0.0 3.3 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO34597.1 - 3.4e-09 36.4 1.3 0.05 13.6 0.0 6.5 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO34597.1 - 6.9e-09 34.9 3.6 0.0051 15.5 0.0 5.4 3 2 3 6 6 6 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO34597.1 - 3.7e-06 26.2 0.2 8e-05 21.9 0.1 2.5 1 1 1 2 2 2 2 Coatomer WD associated region Nbas_N PF15492.6 ETO34597.1 - 9.8e-05 21.8 1.2 6.8 5.9 0.0 4.1 1 1 3 4 4 4 2 Neuroblastoma-amplified sequence, N terminal DUF5570 PF17731.1 ETO34597.1 - 0.00033 20.7 1.3 4.9 7.3 0.0 4.9 3 2 3 6 6 6 1 Family of unknown function (DUF5570) PQQ_2 PF13360.6 ETO34597.1 - 0.0012 18.5 0.5 0.011 15.3 0.4 2.3 1 1 0 1 1 1 1 PQQ-like domain PQQ PF01011.21 ETO34597.1 - 0.0017 18.2 0.1 5.9 7.0 0.0 4.4 4 0 0 4 4 4 1 PQQ enzyme repeat Cytochrom_D1 PF02239.16 ETO34597.1 - 0.012 14.2 0.3 5.6 5.4 0.0 2.7 1 1 1 3 3 3 0 Cytochrome D1 heme domain Proteasome_A_N PF10584.9 ETO34597.1 - 2.2 8.0 6.6 8 6.2 0.0 4.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature eIF3_p135 PF12807.7 ETO34599.1 - 0.0094 16.0 3.2 0.013 15.6 3.1 1.4 1 1 0 1 1 1 1 Translation initiation factor eIF3 subunit 135 ZapB PF06005.12 ETO34600.1 - 0.0062 17.0 5.2 0.0062 17.0 5.2 6.7 2 1 2 5 5 5 3 Cell division protein ZapB HALZ PF02183.18 ETO34601.1 - 0.0073 16.5 2.0 0.0073 16.5 2.0 1.9 2 0 0 2 2 2 1 Homeobox associated leucine zipper FtsL PF04999.13 ETO34601.1 - 0.025 14.6 2.5 0.94 9.5 2.0 2.2 2 0 0 2 2 2 0 Cell division protein FtsL Atg14 PF10186.9 ETO34601.1 - 0.21 10.7 4.5 0.24 10.4 4.5 1.1 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 YabA PF06156.13 ETO34601.1 - 4.1 8.1 9.7 1.5 9.5 6.4 2.1 2 1 0 2 2 2 0 Initiation control protein YabA LPP PF04728.13 ETO34601.1 - 5.1 7.6 7.5 9.8 6.7 2.7 2.6 2 1 0 2 2 2 0 Lipoprotein leucine-zipper DUF3446 PF11928.8 ETO34604.1 - 0.027 14.8 14.8 0.46 10.8 4.1 2.6 2 0 0 2 2 2 0 Early growth response N-terminal domain KH_1 PF00013.29 ETO34604.1 - 0.12 12.3 0.0 0.32 10.9 0.0 1.7 1 0 0 1 1 1 0 KH domain CDC48_N PF02359.18 ETO34604.1 - 0.22 11.7 0.9 0.77 10.0 0.1 2.3 3 0 0 3 3 3 0 Cell division protein 48 (CDC48), N-terminal domain DUF2847 PF11009.8 ETO34605.1 - 0.37 10.7 3.8 0.42 10.5 0.1 2.7 2 1 1 3 3 3 0 Protein of unknown function (DUF2847) RRM_1 PF00076.22 ETO34606.1 - 3e-33 113.4 0.1 8.7e-17 60.7 0.0 4.2 3 1 0 3 3 3 3 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_occluded PF16842.5 ETO34606.1 - 2.4e-05 24.1 0.0 0.22 11.4 0.0 3.3 3 1 0 3 3 3 2 Occluded RNA-recognition motif RRM_9 PF18444.1 ETO34606.1 - 0.012 15.5 0.0 0.043 13.7 0.0 1.9 2 0 0 2 2 2 0 RNA recognition motif RRM_7 PF16367.5 ETO34606.1 - 0.016 15.3 0.0 0.074 13.2 0.0 2.1 2 0 0 2 2 2 0 RNA recognition motif LMBR1 PF04791.16 ETO34606.1 - 0.43 9.4 2.0 0.64 8.9 2.0 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein PIG-F PF06699.11 ETO34607.1 - 1.4e-13 51.4 1.7 1.6e-13 51.2 1.7 1.1 1 0 0 1 1 1 1 GPI biosynthesis protein family Pig-F LrgB PF04172.16 ETO34607.1 - 0.14 11.7 0.9 0.18 11.3 0.9 1.2 1 0 0 1 1 1 0 LrgB-like family Dicty_REP PF05086.12 ETO34608.1 - 0.24 9.3 3.7 0.27 9.2 3.7 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein RhoGEF PF00621.20 ETO34609.1 - 5.3e-21 75.7 2.9 6e-21 75.5 2.9 1.0 1 0 0 1 1 1 1 RhoGEF domain DUF1493 PF07377.12 ETO34609.1 - 0.017 15.6 1.8 0.031 14.7 1.8 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF1493) IMD PF08397.11 ETO34609.1 - 0.32 10.3 3.3 0.25 10.7 0.7 1.9 1 1 0 2 2 2 0 IRSp53/MIM homology domain UBA PF00627.31 ETO34611.1 - 0.00019 21.3 0.0 0.00035 20.4 0.0 1.5 1 0 0 1 1 1 1 UBA/TS-N domain SR-25 PF10500.9 ETO34611.1 - 0.76 9.4 18.5 1.2 8.6 18.5 1.2 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein CDC45 PF02724.14 ETO34611.1 - 0.77 8.0 10.7 0.97 7.6 10.7 1.1 1 0 0 1 1 1 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO34611.1 - 1.8 8.3 13.1 11 5.7 12.8 2.1 2 0 0 2 2 2 0 Ryanodine Receptor TM 4-6 DUF4637 PF15470.6 ETO34611.1 - 1.8 8.2 10.6 1.5 8.6 7.8 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4637) Vfa1 PF08432.10 ETO34611.1 - 2.4 8.5 15.7 4 7.7 15.7 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Sec62 PF03839.16 ETO34611.1 - 2.5 7.6 6.4 4 6.9 6.4 1.4 1 0 0 1 1 1 0 Translocation protein Sec62 Presenilin PF01080.17 ETO34611.1 - 4.9 5.8 5.5 6.4 5.4 5.5 1.2 1 0 0 1 1 1 0 Presenilin AP3D1 PF06375.11 ETO34611.1 - 4.9 7.4 20.8 8.7 6.6 20.8 1.3 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 VitD-bind_III PF09164.10 ETO34614.1 - 0.13 12.3 1.2 0.2 11.7 1.2 1.3 1 0 0 1 1 1 0 Vitamin D binding protein, domain III Rrn6 PF10214.9 ETO34618.1 - 0.36 9.3 9.4 0.11 11.0 5.8 1.7 2 0 0 2 2 2 0 RNA polymerase I-specific transcription-initiation factor Presenilin PF01080.17 ETO34618.1 - 0.67 8.7 10.8 0.86 8.3 10.8 1.2 1 0 0 1 1 1 0 Presenilin SLC12 PF03522.15 ETO34618.1 - 1.3 8.0 9.1 1.9 7.4 9.1 1.3 1 0 0 1 1 1 0 Solute carrier family 12 DUF3915 PF13054.6 ETO34618.1 - 3.3 7.7 9.2 2.5 8.1 0.1 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3915) DSPn PF14671.6 ETO34620.1 - 2.2e-34 118.9 10.2 8.4e-34 117.0 6.0 3.5 3 2 1 4 4 4 1 Dual specificity protein phosphatase, N-terminal half DSPc PF00782.20 ETO34620.1 - 3.2e-14 52.9 0.1 1.7e-13 50.5 0.0 2.2 2 0 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO34620.1 - 0.00024 20.8 0.0 0.00024 20.8 0.0 2.1 3 0 0 3 3 3 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETO34620.1 - 0.0059 16.7 0.0 0.017 15.2 0.0 1.8 1 0 0 1 1 1 1 Inositol hexakisphosphate DUF3579 PF12112.8 ETO34620.1 - 0.14 12.7 0.4 1.6 9.3 0.2 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3579) G-alpha PF00503.20 ETO34621.1 - 1.9e-59 201.6 10.2 9.3e-59 199.4 10.2 2.0 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO34621.1 - 3.3e-12 46.2 1.9 4e-06 26.4 0.1 2.9 2 1 1 3 3 3 2 ADP-ribosylation factor family UPF0515 PF15135.6 ETO34621.1 - 0.042 13.2 0.1 0.042 13.2 0.1 1.7 2 0 0 2 2 2 0 Uncharacterised protein UPF0515 AAA_18 PF13238.6 ETO34621.1 - 0.05 14.2 1.0 0.17 12.4 0.0 2.4 2 1 0 2 2 2 0 AAA domain Roc PF08477.13 ETO34621.1 - 0.2 11.9 2.7 7.1 6.9 0.1 3.1 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase COesterase PF00135.28 ETO34622.1 - 3e-83 280.4 10.7 2.9e-46 158.4 6.9 3.0 2 1 0 2 2 2 2 Carboxylesterase family WD40 PF00400.32 ETO34623.1 - 0.00024 21.8 0.3 0.0011 19.7 0.1 2.1 2 1 0 2 2 2 1 WD domain, G-beta repeat p450 PF00067.22 ETO34625.1 - 3.4e-26 92.0 0.1 6.5e-26 91.1 0.1 1.4 1 1 0 1 1 1 1 Cytochrome P450 p450 PF00067.22 ETO34626.1 - 1.2e-09 37.5 1.6 6.6e-08 31.7 2.1 1.9 1 1 1 2 2 2 2 Cytochrome P450 Bul1_N PF04425.12 ETO34626.1 - 0.077 11.7 0.1 0.077 11.7 0.1 1.6 2 0 0 2 2 2 0 Bul1 N terminus WD40 PF00400.32 ETO34628.1 - 1.1e-35 121.0 23.4 1.1e-05 26.1 0.1 7.5 7 3 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO34628.1 - 1.1e-11 44.2 3.5 0.0022 16.8 0.1 4.4 1 1 3 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34628.1 - 1.1e-10 41.6 0.5 0.0087 16.3 0.0 5.1 4 2 2 6 6 6 2 Anaphase-promoting complex subunit 4 WD40 domain VEFS-Box PF09733.9 ETO34628.1 - 0.12 12.2 1.5 0.23 11.3 0.8 1.8 2 0 0 2 2 2 0 VEFS-Box of polycomb protein WD40 PF00400.32 ETO34629.1 - 7.3e-21 74.1 9.3 1.9e-06 28.5 0.8 4.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34629.1 - 1.1e-08 35.2 0.1 0.0036 17.6 0.0 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34629.1 - 1.2e-06 27.5 1.3 0.37 9.4 0.0 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34629.1 - 0.00037 19.9 1.5 0.04 13.2 0.9 2.6 1 1 2 3 3 3 1 WD40-like domain BBS2_Mid PF14783.6 ETO34629.1 - 0.0051 16.8 0.2 0.26 11.3 0.3 2.4 1 1 1 2 2 2 1 Ciliary BBSome complex subunit 2, middle region DUF4221 PF13970.6 ETO34629.1 - 0.019 14.5 0.5 0.26 10.8 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) Kelch_6 PF13964.6 ETO34629.1 - 0.1 12.9 1.6 7.6 7.0 0.0 3.0 3 0 0 3 3 3 0 Kelch motif ATP-sulfurylase PF01747.17 ETO34631.1 - 1.4e-76 256.7 0.1 3.6e-76 255.4 0.1 1.7 1 1 0 1 1 1 1 ATP-sulfurylase APS_kinase PF01583.20 ETO34631.1 - 2.4e-51 173.8 0.0 5.3e-51 172.6 0.0 1.6 2 0 0 2 2 2 1 Adenylylsulphate kinase PUA_2 PF14306.6 ETO34631.1 - 1.3e-40 138.7 0.0 2.1e-40 138.0 0.0 1.3 1 0 0 1 1 1 1 PUA-like domain AAA_18 PF13238.6 ETO34631.1 - 2.3e-05 25.0 0.0 0.00049 20.7 0.0 2.8 3 0 0 3 3 2 1 AAA domain AAA_33 PF13671.6 ETO34631.1 - 5.6e-05 23.3 0.0 0.00012 22.3 0.0 1.4 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ETO34631.1 - 0.00044 19.6 0.0 0.001 18.4 0.0 1.6 1 0 0 1 1 1 1 Zeta toxin AAA_29 PF13555.6 ETO34631.1 - 0.00054 19.7 0.0 0.0012 18.6 0.0 1.5 1 0 0 1 1 1 1 P-loop containing region of AAA domain CbiA PF01656.23 ETO34631.1 - 0.0013 18.8 0.0 0.0022 18.1 0.0 1.4 1 0 0 1 1 1 1 CobQ/CobB/MinD/ParA nucleotide binding domain KTI12 PF08433.10 ETO34631.1 - 0.0027 17.2 0.0 0.0038 16.7 0.0 1.2 1 0 0 1 1 1 1 Chromatin associated protein KTI12 ABC_tran PF00005.27 ETO34631.1 - 0.0051 17.3 0.0 0.011 16.3 0.0 1.5 1 0 0 1 1 1 1 ABC transporter MeaB PF03308.16 ETO34631.1 - 0.0061 15.6 0.0 0.01 14.8 0.0 1.3 1 0 0 1 1 1 1 Methylmalonyl Co-A mutase-associated GTPase MeaB AAA_16 PF13191.6 ETO34631.1 - 0.0077 16.6 0.0 0.014 15.8 0.0 1.4 1 0 0 1 1 1 1 AAA ATPase domain Sigma54_activat PF00158.26 ETO34631.1 - 0.0077 15.9 0.0 0.013 15.2 0.0 1.3 1 0 0 1 1 1 1 Sigma-54 interaction domain AAA_17 PF13207.6 ETO34631.1 - 0.013 16.0 0.0 0.033 14.6 0.0 1.7 1 0 0 1 1 1 0 AAA domain AAA_22 PF13401.6 ETO34631.1 - 0.018 15.3 0.0 0.053 13.8 0.0 1.8 1 1 0 1 1 1 0 AAA domain G-alpha PF00503.20 ETO34631.1 - 0.024 13.8 0.0 0.038 13.1 0.0 1.2 1 0 0 1 1 1 0 G-protein alpha subunit RsgA_GTPase PF03193.16 ETO34631.1 - 0.029 14.3 0.0 0.055 13.4 0.0 1.3 1 0 0 1 1 1 0 RsgA GTPase AAA_30 PF13604.6 ETO34631.1 - 0.058 13.1 0.0 0.098 12.4 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO34631.1 - 0.065 13.7 0.0 0.12 12.9 0.0 1.4 1 0 0 1 1 1 0 AAA domain AAA_28 PF13521.6 ETO34631.1 - 0.073 13.3 0.0 0.21 11.8 0.0 1.7 2 0 0 2 2 2 0 AAA domain Thymidylate_kin PF02223.17 ETO34631.1 - 0.13 11.9 0.0 0.53 9.9 0.0 1.9 2 0 0 2 2 2 0 Thymidylate kinase T2SSE PF00437.20 ETO34631.1 - 0.14 11.2 0.0 0.35 9.9 0.0 1.5 2 0 0 2 2 2 0 Type II/IV secretion system protein SRP54 PF00448.22 ETO34631.1 - 0.15 11.7 0.0 0.25 10.9 0.0 1.2 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain WD40 PF00400.32 ETO34632.1 - 1e-44 149.6 25.8 3.2e-07 30.9 1.0 8.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34632.1 - 2e-15 56.9 1.4 0.0006 20.1 0.0 6.2 6 1 1 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34632.1 - 1.3e-12 47.2 4.4 0.012 14.2 0.0 5.5 2 2 3 5 5 5 5 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO34632.1 - 1.1e-05 26.0 3.2 1.1e-05 26.0 3.2 3.9 4 0 0 4 4 4 1 TRAF-type zinc finger WBS_methylT PF12589.8 ETO34632.1 - 0.32 11.8 6.3 1.4 9.7 4.0 2.5 2 0 0 2 2 2 0 Methyltransferase involved in Williams-Beuren syndrome TPR_12 PF13424.6 ETO34633.1 - 0.0018 18.5 0.0 0.0036 17.6 0.0 1.5 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34633.1 - 0.0046 16.7 1.8 2.3 8.2 1.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat WD40 PF00400.32 ETO34634.1 - 4.8e-36 122.1 23.4 2.1e-07 31.5 0.3 7.8 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34634.1 - 2.5e-15 56.5 4.4 0.018 15.3 0.0 6.1 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34634.1 - 3.9e-10 39.0 5.6 0.004 15.9 0.1 4.2 1 1 3 4 4 4 4 Nucleoporin Nup120/160 CHZ PF09649.10 ETO34634.1 - 1.9 8.1 4.4 2.8 7.5 0.8 2.5 2 0 0 2 2 2 0 Histone chaperone domain CHZ WD40 PF00400.32 ETO34635.1 - 1.6e-12 47.7 6.8 9.1e-07 29.5 0.3 3.2 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34635.1 - 0.00016 21.9 0.0 0.0093 16.2 0.0 2.2 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain CutA1 PF03091.15 ETO34637.1 - 0.075 12.9 2.3 0.37 10.7 1.1 2.1 2 0 0 2 2 2 0 CutA1 divalent ion tolerance protein RP-C_C PF11800.8 ETO34638.1 - 0.024 14.7 5.7 0.028 14.5 5.7 1.0 1 0 0 1 1 1 0 Replication protein C C-terminal region TRM13 PF05206.14 ETO34638.1 - 0.026 14.0 3.6 0.031 13.8 3.6 1.2 1 0 0 1 1 1 0 Methyltransferase TRM13 DUF1117 PF06547.12 ETO34638.1 - 0.2 12.2 0.4 0.25 11.9 0.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1117) V_ATPase_I PF01496.19 ETO34638.1 - 0.35 8.7 8.7 0.4 8.5 8.7 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DDHD PF02862.17 ETO34638.1 - 0.42 10.7 4.8 0.47 10.6 4.8 1.1 1 0 0 1 1 1 0 DDHD domain SID-1_RNA_chan PF13965.6 ETO34638.1 - 0.5 8.7 2.3 0.59 8.5 2.3 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 ALMT PF11744.8 ETO34638.1 - 0.65 8.8 9.6 0.74 8.6 9.6 1.0 1 0 0 1 1 1 0 Aluminium activated malate transporter Presenilin PF01080.17 ETO34638.1 - 2.6 6.7 5.6 2.6 6.7 5.6 1.1 1 0 0 1 1 1 0 Presenilin RelA_SpoT PF04607.17 ETO34639.1 - 0.0016 18.7 2.7 0.0018 18.6 0.9 2.0 2 0 0 2 2 2 1 Region found in RelA / SpoT proteins DUF5126 PF17166.4 ETO34639.1 - 0.053 13.4 0.5 0.14 12.1 0.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5126) NACHT PF05729.12 ETO34640.1 - 5.3e-10 39.5 0.0 1.2e-09 38.3 0.0 1.6 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO34640.1 - 0.0096 16.5 0.1 0.037 14.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain RNA_helicase PF00910.22 ETO34640.1 - 0.014 15.8 2.3 0.036 14.4 0.1 2.8 2 1 0 3 3 3 0 RNA helicase AAA_22 PF13401.6 ETO34640.1 - 0.021 15.1 0.0 0.062 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain Sigma_1s PF02454.16 ETO34640.1 - 0.18 11.8 2.4 1.7 8.7 0.2 2.7 2 0 0 2 2 2 0 Sigma 1s protein DUF3763 PF12592.8 ETO34640.1 - 0.4 10.8 2.9 10 6.3 0.4 3.0 3 0 0 3 3 3 0 Protein of unknown function (DUF3763) CbiA PF01656.23 ETO34640.1 - 6 6.9 6.3 16 5.5 0.0 3.5 3 2 1 4 4 4 0 CobQ/CobB/MinD/ParA nucleotide binding domain WD40 PF00400.32 ETO34644.1 - 2.3e-54 180.1 19.8 1.7e-10 41.3 0.3 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34644.1 - 3e-26 91.5 2.6 8e-06 26.1 0.0 5.4 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34644.1 - 1.2e-11 44.2 2.5 0.02 13.9 0.1 6.0 1 1 6 7 7 7 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO34644.1 - 4.7e-09 35.9 0.5 5 7.2 0.0 7.2 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO34644.1 - 9.2e-08 31.8 1.2 0.0084 15.5 0.1 3.9 2 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO34644.1 - 3e-05 22.9 3.7 2.2 6.8 0.0 5.0 3 2 2 5 5 5 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO34644.1 - 0.0011 17.5 2.2 0.17 10.4 0.1 3.1 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO34644.1 - 0.0053 16.1 2.6 1.2 8.4 0.0 3.6 1 1 2 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO34644.1 - 0.023 13.5 6.7 0.98 8.1 0.4 4.0 1 1 2 4 4 4 0 Nup133 N terminal like Str_synth PF03088.16 ETO34644.1 - 0.057 13.5 0.1 7.6 6.7 0.0 3.2 2 1 1 3 3 3 0 Strictosidine synthase PUB PF09409.10 ETO34646.1 - 0.13 12.2 2.4 1.4 8.9 2.4 2.5 1 1 0 1 1 1 0 PUB domain Sin3_corepress PF08295.12 ETO34647.1 - 0.005 16.9 0.5 1.4 9.0 0.1 2.2 2 0 0 2 2 2 2 Sin3 family co-repressor DKNYY PF13644.6 ETO34647.1 - 0.033 14.9 2.4 0.46 11.3 0.9 2.2 1 1 1 2 2 2 0 DKNYY family RVT_1 PF00078.27 ETO34648.1 - 4.5e-37 127.7 0.7 4.5e-37 127.7 0.7 2.0 2 0 0 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 ETO34648.1 - 0.031 13.8 0.0 0.06 12.8 0.0 1.5 1 0 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family ZFYVE21_C PF16696.5 ETO34648.1 - 0.041 13.7 0.0 1.1 9.1 0.0 2.8 2 0 0 2 2 2 0 Zinc finger FYVE domain-containing protein 21 C-terminus SAP PF02037.27 ETO34648.1 - 0.13 12.0 0.0 1.9 8.3 0.0 2.6 2 0 0 2 2 2 0 SAP domain PCI PF01399.27 ETO34648.1 - 7 7.2 8.3 13 6.3 0.1 3.9 4 0 0 4 4 4 0 PCI domain zf-C2H2_9 PF16293.5 ETO34649.1 - 0.019 14.8 0.1 0.083 12.8 0.1 2.1 1 0 0 1 1 1 0 C2H2 type zinc-finger (1 copy) MCC-bdg_PDZ PF10506.9 ETO34649.1 - 0.13 12.3 2.5 0.34 11.0 2.5 1.7 1 0 0 1 1 1 0 PDZ domain of MCC-2 bdg protein for Usher syndrome Pro_CA PF00484.19 ETO34650.1 - 0.0013 19.0 0.0 0.0023 18.3 0.0 1.3 1 0 0 1 1 1 1 Carbonic anhydrase Glyco_hydro_20 PF00728.22 ETO34651.1 - 1.9e-20 73.6 4.0 1.4e-19 70.8 4.0 1.9 1 1 0 1 1 1 1 Glycosyl hydrolase family 20, catalytic domain FWWh PF14922.6 ETO34652.1 - 2.3e-06 27.6 6.0 0.0081 16.1 0.1 2.8 1 1 0 2 2 2 2 Protein of unknown function Taxilin PF09728.9 ETO34654.1 - 0.056 12.6 2.0 0.071 12.3 2.0 1.2 1 0 0 1 1 1 0 Myosin-like coiled-coil protein zf-C3HC4_2 PF13923.6 ETO34654.1 - 0.074 12.9 0.1 0.2 11.5 0.1 1.7 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Actin PF00022.19 ETO34656.1 - 2.4e-83 280.0 0.0 1.1e-82 277.9 0.0 1.8 1 1 0 1 1 1 1 Actin Yippee-Mis18 PF03226.14 ETO34657.1 - 5e-11 42.8 1.3 1.6e-10 41.1 1.3 1.9 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly ERM PF00769.19 ETO34657.1 - 2.3e-05 24.3 16.4 3.3e-05 23.8 16.4 1.1 1 0 0 1 1 1 1 Ezrin/radixin/moesin family FAM76 PF16046.5 ETO34657.1 - 0.00012 21.5 12.4 0.00012 21.5 12.4 2.3 1 1 1 2 2 1 1 FAM76 protein Spc7 PF08317.11 ETO34657.1 - 0.00018 20.5 14.7 0.00027 19.9 14.7 1.2 1 0 0 1 1 1 1 Spc7 kinetochore protein UPF0242 PF06785.11 ETO34657.1 - 0.00063 19.9 12.8 0.0012 19.0 12.8 1.4 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus DUF3450 PF11932.8 ETO34657.1 - 0.001 18.4 13.9 0.0017 17.7 13.9 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF3584 PF12128.8 ETO34657.1 - 0.001 16.7 9.1 0.0012 16.5 9.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF3584) Filament PF00038.21 ETO34657.1 - 0.0013 18.3 13.0 0.0022 17.6 13.0 1.2 1 0 0 1 1 1 1 Intermediate filament protein FapA PF03961.13 ETO34657.1 - 0.0014 17.3 11.4 0.0019 16.9 11.4 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A HAUS5 PF14817.6 ETO34657.1 - 0.0016 17.3 7.2 0.0019 17.0 7.2 1.0 1 0 0 1 1 1 1 HAUS augmin-like complex subunit 5 DivIC PF04977.15 ETO34657.1 - 0.0018 18.0 13.8 0.092 12.5 0.3 2.3 1 1 1 2 2 2 2 Septum formation initiator OmpH PF03938.14 ETO34657.1 - 0.0036 17.6 12.5 0.0074 16.6 12.5 1.5 1 0 0 1 1 1 1 Outer membrane protein (OmpH-like) zf-C4H2 PF10146.9 ETO34657.1 - 0.0039 17.5 11.8 0.0062 16.9 11.8 1.3 1 0 0 1 1 1 1 Zinc finger-containing protein BRE1 PF08647.11 ETO34657.1 - 0.0086 16.1 18.7 0.0086 16.1 18.7 1.8 2 0 0 2 2 1 1 BRE1 E3 ubiquitin ligase Hamartin PF04388.12 ETO34657.1 - 0.01 14.6 14.5 0.011 14.4 14.5 1.1 1 0 0 1 1 1 0 Hamartin protein DUF724 PF05266.14 ETO34657.1 - 0.011 15.5 17.3 0.011 15.5 17.3 1.5 2 0 0 2 2 1 0 Protein of unknown function (DUF724) V_ATPase_I PF01496.19 ETO34657.1 - 0.014 13.4 10.2 0.015 13.2 10.2 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Seryl_tRNA_N PF02403.22 ETO34657.1 - 0.016 15.4 11.7 0.016 15.4 11.7 2.0 2 0 0 2 2 1 0 Seryl-tRNA synthetase N-terminal domain DUF2353 PF09789.9 ETO34657.1 - 0.024 14.0 16.3 0.029 13.7 15.9 1.3 1 1 0 1 1 1 0 Uncharacterized coiled-coil protein (DUF2353) TPR_MLP1_2 PF07926.12 ETO34657.1 - 0.032 14.3 17.7 0.096 12.8 17.7 1.8 1 0 0 1 1 1 0 TPR/MLP1/MLP2-like protein DUF4200 PF13863.6 ETO34657.1 - 0.074 13.4 15.9 0.17 12.3 15.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) Laminin_II PF06009.12 ETO34657.1 - 0.078 13.0 11.4 0.18 11.8 11.4 1.5 1 0 0 1 1 1 0 Laminin Domain II THOC7 PF05615.13 ETO34657.1 - 0.08 13.2 11.4 0.18 12.1 11.4 1.5 1 0 0 1 1 1 0 Tho complex subunit 7 Phos_pyr_kin PF08543.12 ETO34657.1 - 0.096 12.0 2.7 0.13 11.6 2.7 1.3 1 0 0 1 1 1 0 Phosphomethylpyrimidine kinase CCDC85 PF10226.9 ETO34657.1 - 0.099 12.3 10.2 0.15 11.7 10.2 1.2 1 0 0 1 1 1 0 CCDC85 family NUDE_C PF04880.13 ETO34657.1 - 0.13 12.7 17.4 0.13 12.7 16.0 1.8 1 1 0 1 1 1 0 NUDE protein, C-terminal conserved region zf-HYPF PF07503.12 ETO34657.1 - 0.13 12.0 1.2 5.7 6.8 0.0 2.3 2 0 0 2 2 2 0 HypF finger GFA PF04828.14 ETO34657.1 - 0.14 12.5 6.4 2.5 8.5 0.3 3.3 2 1 1 3 3 3 0 Glutathione-dependent formaldehyde-activating enzyme PGA_cap PF09587.10 ETO34657.1 - 0.15 11.5 3.5 0.16 11.4 2.7 1.4 1 1 0 1 1 1 0 Bacterial capsule synthesis protein PGA_cap JIP_LZII PF16471.5 ETO34657.1 - 0.16 12.1 20.0 0.37 11.0 2.3 3.4 2 1 1 3 3 3 0 JNK-interacting protein leucine zipper II GAS PF13851.6 ETO34657.1 - 0.18 11.1 24.2 0.19 11.0 14.1 2.2 1 1 1 2 2 2 0 Growth-arrest specific micro-tubule binding TEX13 PF15186.6 ETO34657.1 - 0.19 11.4 11.6 0.34 10.6 11.6 1.4 1 0 0 1 1 1 0 Testis-expressed sequence 13 protein family Fez1 PF06818.15 ETO34657.1 - 0.24 11.8 21.5 0.41 11.1 21.5 1.4 1 1 0 1 1 1 0 Fez1 AAA_13 PF13166.6 ETO34657.1 - 0.29 9.7 17.2 0.035 12.8 12.8 1.5 1 1 0 1 1 1 0 AAA domain Exonuc_VII_L PF02601.15 ETO34657.1 - 0.36 10.4 7.3 0.5 9.9 7.3 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Lebercilin PF15619.6 ETO34657.1 - 0.44 10.2 21.6 2.3 7.8 21.7 1.9 1 1 0 1 1 1 0 Ciliary protein causing Leber congenital amaurosis disease DUF4618 PF15397.6 ETO34657.1 - 0.46 9.9 17.7 12 5.2 17.8 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF4618) LMBR1 PF04791.16 ETO34657.1 - 0.52 9.2 8.1 0.65 8.8 8.1 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein IFT57 PF10498.9 ETO34657.1 - 0.53 9.2 19.5 0.076 12.0 15.3 1.6 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 Tweety PF04906.13 ETO34657.1 - 0.57 8.8 4.8 0.89 8.2 4.8 1.2 1 0 0 1 1 1 0 Tweety APG6_N PF17675.1 ETO34657.1 - 0.58 10.7 28.4 0.43 11.1 24.3 2.3 2 1 0 2 2 1 0 Apg6 coiled-coil region DUF4140 PF13600.6 ETO34657.1 - 0.59 10.6 11.3 1.7 9.2 0.7 2.6 1 1 1 2 2 2 0 N-terminal domain of unknown function (DUF4140) CENP-Q PF13094.6 ETO34657.1 - 0.6 10.3 18.9 1.1 9.5 18.9 1.4 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF1664 PF07889.12 ETO34657.1 - 0.6 10.1 11.0 2.9 8.0 11.0 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Ax_dynein_light PF10211.9 ETO34657.1 - 0.65 9.9 15.9 1.3 8.9 15.9 1.5 1 0 0 1 1 1 0 Axonemal dynein light chain ZapB PF06005.12 ETO34657.1 - 0.79 10.2 24.4 2 8.9 10.2 2.3 1 1 1 2 2 2 0 Cell division protein ZapB DUF4763 PF15960.5 ETO34657.1 - 0.8 9.0 18.4 0.35 10.2 13.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4763) HIP1_clath_bdg PF16515.5 ETO34657.1 - 0.84 10.3 23.3 0.59 10.8 21.2 1.9 1 1 0 1 1 1 0 Clathrin-binding domain of Huntingtin-interacting protein 1 YabA PF06156.13 ETO34657.1 - 0.92 10.2 17.7 0.58 10.8 9.8 2.4 1 1 1 2 2 2 0 Initiation control protein YabA DivIVA PF05103.13 ETO34657.1 - 1.1 9.4 14.4 2.1 8.4 14.4 1.5 1 0 0 1 1 1 0 DivIVA protein Prefoldin_2 PF01920.20 ETO34657.1 - 1.1 9.3 21.8 5.5 7.0 4.0 2.5 1 1 1 2 2 2 0 Prefoldin subunit 5_nucleotid PF05761.14 ETO34657.1 - 1.2 8.0 9.2 1.6 7.5 9.2 1.3 1 0 0 1 1 1 0 5' nucleotidase family Cep57_CLD_2 PF14197.6 ETO34657.1 - 1.3 9.2 18.1 8.7 6.5 1.3 2.4 1 1 1 2 2 2 0 Centrosome localisation domain of PPC89 DUF641 PF04859.12 ETO34657.1 - 1.4 9.3 15.0 0.082 13.2 5.9 2.3 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) CorA PF01544.18 ETO34657.1 - 1.4 8.2 4.9 1.3 8.3 1.0 1.9 1 1 1 2 2 2 0 CorA-like Mg2+ transporter protein DUF4315 PF14193.6 ETO34657.1 - 1.6 8.8 18.1 3.2 7.8 8.0 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4315) bZIP_1 PF00170.21 ETO34657.1 - 2.1 8.5 20.4 2.6 8.2 8.6 2.9 1 1 1 2 2 2 0 bZIP transcription factor Tup_N PF08581.10 ETO34657.1 - 2.2 8.6 13.5 0.59 10.5 7.5 2.4 1 1 1 2 2 2 0 Tup N-terminal DUF2730 PF10805.8 ETO34657.1 - 2.2 8.4 11.4 1.7 8.8 8.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) KfrA_N PF11740.8 ETO34657.1 - 2.4 8.9 13.3 5 7.8 13.3 1.5 1 1 0 1 1 1 0 Plasmid replication region DNA-binding N-term MMPL PF03176.15 ETO34657.1 - 2.6 6.9 3.7 3.3 6.5 3.7 1.2 1 0 0 1 1 1 0 MMPL family DUF812 PF05667.11 ETO34657.1 - 2.7 6.8 24.6 0.48 9.2 20.9 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF812) CENP-F_leu_zip PF10473.9 ETO34657.1 - 2.7 8.0 26.0 2.8 7.9 23.9 2.2 2 1 0 2 2 1 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 TolA_bind_tri PF16331.5 ETO34657.1 - 2.8 8.1 12.9 5.4 7.2 8.6 2.5 1 1 1 2 2 2 0 TolA binding protein trimerisation TMF_TATA_bd PF12325.8 ETO34657.1 - 3.2 8.0 22.7 0.46 10.7 11.3 2.5 1 1 1 2 2 2 0 TATA element modulatory factor 1 TATA binding Presenilin PF01080.17 ETO34657.1 - 3.3 6.4 11.3 4.7 5.9 11.3 1.3 1 0 0 1 1 1 0 Presenilin DUF4201 PF13870.6 ETO34657.1 - 3.9 7.2 20.9 2.3 7.9 17.6 2.1 2 1 0 2 2 1 0 Domain of unknown function (DUF4201) DUF4407 PF14362.6 ETO34657.1 - 5.7 6.2 11.9 12 5.2 11.9 1.5 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) DUF730 PF05325.11 ETO34657.1 - 5.8 7.0 10.2 6.1 6.9 5.4 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF730) ATG16 PF08614.11 ETO34657.1 - 5.9 7.1 28.9 0.079 13.2 19.5 2.0 1 1 0 2 2 2 0 Autophagy protein 16 (ATG16) HAUS6_N PF14661.6 ETO34657.1 - 6.3 6.3 17.0 9.8 5.7 17.0 1.4 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 6 N-terminus Occludin_ELL PF07303.13 ETO34657.1 - 6.5 7.5 11.6 33 5.3 11.3 2.1 1 1 1 2 2 2 0 Occludin homology domain DUF4298 PF14131.6 ETO34657.1 - 6.5 6.8 11.1 3.5 7.7 1.6 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4298) DUF2968 PF11180.8 ETO34657.1 - 6.6 6.3 14.8 8.7 5.9 8.0 2.1 1 1 0 2 2 2 0 Protein of unknown function (DUF2968) Golgin_A5 PF09787.9 ETO34657.1 - 8.3 5.8 22.9 29 4.0 22.8 1.8 1 1 0 1 1 1 0 Golgin subfamily A member 5 DUF16 PF01519.16 ETO34657.1 - 8.9 6.9 13.3 68 4.0 13.3 2.1 1 1 0 1 1 1 0 Protein of unknown function DUF16 ELO PF01151.18 ETO34658.1 - 1.3e-20 74.0 19.5 3.2e-18 66.2 17.7 2.8 1 1 1 2 2 2 1 GNS1/SUR4 family CBS PF00571.28 ETO34659.1 - 0.016 15.7 0.0 0.069 13.6 0.0 2.0 1 1 0 1 1 1 0 CBS domain Mitofilin PF09731.9 ETO34660.1 - 0.1 11.4 25.8 0.13 11.1 25.8 1.2 1 0 0 1 1 1 0 Mitochondrial inner membrane protein CDC27 PF09507.10 ETO34660.1 - 0.15 11.5 38.0 0.2 11.0 38.0 1.1 1 0 0 1 1 1 0 DNA polymerase subunit Cdc27 Glyco_transf_41 PF13844.6 ETO34660.1 - 0.2 10.1 5.7 0.31 9.4 5.7 1.3 1 0 0 1 1 1 0 Glycosyl transferase family 41 SLC12 PF03522.15 ETO34660.1 - 1.3 8.0 20.8 1.9 7.4 20.8 1.3 1 0 0 1 1 1 0 Solute carrier family 12 Coilin_N PF15862.5 ETO34660.1 - 2.6 7.9 30.2 0.013 15.3 7.4 2.4 1 1 1 2 2 2 0 Coilin N-terminus Med19 PF10278.9 ETO34660.1 - 3.1 7.7 39.8 0.062 13.2 16.0 2.2 2 0 0 2 2 2 0 Mediator of RNA pol II transcription subunit 19 Peptidase_S49_N PF08496.10 ETO34660.1 - 3.4 7.7 30.8 3.2 7.8 9.4 3.3 3 0 0 3 3 3 0 Peptidase family S49 N-terminal SOBP PF15279.6 ETO34660.1 - 7.6 7.0 17.8 16 6.0 17.8 1.4 1 0 0 1 1 1 0 Sine oculis-binding protein WD40 PF00400.32 ETO34661.1 - 7.4e-17 61.4 0.1 2.4e-06 28.1 0.0 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO34661.1 - 0.0091 14.7 0.2 1.8 7.1 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 KicB PF03882.14 ETO34663.1 - 0.11 12.8 0.1 20 5.4 0.0 2.5 1 1 2 3 3 3 0 MukF winged-helix domain CLASP_N PF12348.8 ETO34664.1 - 0.00023 20.8 0.5 0.00044 19.9 0.4 1.5 1 1 0 1 1 1 1 CLASP N terminal HEAT PF02985.22 ETO34664.1 - 0.0082 16.3 0.0 0.081 13.2 0.0 2.5 2 0 0 2 2 2 1 HEAT repeat RICTOR_N PF14664.6 ETO34664.1 - 0.018 14.1 3.2 0.075 12.0 3.2 1.8 1 1 0 1 1 1 0 Rapamycin-insensitive companion of mTOR, N-term RTP1_C1 PF10363.9 ETO34664.1 - 0.054 13.7 0.3 0.53 10.5 0.3 2.1 1 1 0 1 1 1 0 Required for nuclear transport of RNA pol II C-terminus 1 WD40 PF00400.32 ETO34665.1 - 8.6e-32 108.7 8.3 3.9e-10 40.2 0.2 7.1 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34665.1 - 1.6e-13 50.8 0.1 0.012 15.9 0.0 5.7 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34665.1 - 1.1e-11 44.3 0.2 0.0013 17.8 0.1 5.4 2 2 3 5 5 5 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO34665.1 - 6.9e-05 21.5 0.1 0.7 8.4 0.0 3.4 1 1 3 4 4 4 3 Cytochrome D1 heme domain Frtz PF11768.8 ETO34665.1 - 0.00017 20.1 0.2 1.2 7.4 0.0 3.8 2 1 2 4 4 4 2 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO34665.1 - 0.0005 19.9 7.5 14 5.8 0.0 5.6 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat BBS2_Mid PF14783.6 ETO34665.1 - 0.012 15.6 1.1 14 5.8 0.0 3.5 3 1 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Plk4_PB1 PF18190.1 ETO34665.1 - 0.19 11.9 1.6 3.2 8.0 0.1 3.2 3 1 1 4 4 4 0 Polo-like Kinase 4 Polo Box 1 G-alpha PF00503.20 ETO34666.1 - 5.9e-31 107.9 1.7 7.1e-31 107.7 1.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit RRM_4 PF10598.9 ETO34666.1 - 0.064 13.6 0.4 0.11 12.9 0.4 1.4 1 0 0 1 1 1 0 RNA recognition motif of the spliceosomal PrP8 G-alpha PF00503.20 ETO34667.1 - 2.9e-58 197.7 2.3 1.5e-57 195.4 2.3 1.8 1 1 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO34667.1 - 3.3e-11 42.9 0.8 7.1e-08 32.1 0.2 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO34667.1 - 0.0014 18.9 1.7 0.74 10.1 0.0 2.7 2 1 1 3 3 3 2 Ras of Complex, Roc, domain of DAPkinase POX PF07526.11 ETO34667.1 - 0.21 12.2 0.8 0.41 11.2 0.8 1.5 1 1 0 1 1 1 0 Associated with HOX TPR_10 PF13374.6 ETO34668.1 - 5.6e-15 54.7 0.0 2.3e-10 40.0 0.0 3.7 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO34668.1 - 1.2e-14 54.3 0.0 1.1e-11 44.9 0.1 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34668.1 - 2.9e-13 48.9 2.0 7.1e-09 35.2 0.5 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34668.1 - 1.4e-12 46.7 0.0 1.3e-08 34.3 0.0 2.7 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34668.1 - 1.1e-11 44.0 1.1 2.4e-10 39.8 0.7 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34668.1 - 8.3e-11 41.2 0.4 1.4e-07 31.1 0.2 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO34668.1 - 3.8e-07 29.7 1.1 0.0024 17.5 0.1 3.3 2 1 1 3 3 3 2 TPR repeat TPR_6 PF13174.6 ETO34668.1 - 6.6e-06 26.4 0.0 0.15 12.8 0.0 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34668.1 - 1.2e-05 25.4 0.1 0.00034 20.8 0.1 2.5 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO34668.1 - 0.00067 19.6 0.1 0.0013 18.6 0.1 1.5 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO34668.1 - 0.015 15.9 0.0 0.19 12.4 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat MIT PF04212.18 ETO34668.1 - 0.033 14.2 1.8 0.042 13.9 0.4 1.9 2 1 0 2 2 2 0 MIT (microtubule interacting and transport) domain HNH_4 PF13395.6 ETO34668.1 - 0.075 13.0 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 HNH endonuclease WD40 PF00400.32 ETO34669.1 - 2.3e-08 34.5 1.6 0.00051 20.8 0.0 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat Secretin_N_2 PF07655.13 ETO34669.1 - 0.051 14.1 19.5 0.34 11.5 5.0 3.7 3 0 0 3 3 3 0 Secretin N-terminal domain ETRAMP PF09716.10 ETO34669.1 - 0.11 12.6 10.5 0.85 9.7 0.2 3.7 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) Sec62 PF03839.16 ETO34669.1 - 3.1 7.3 8.8 1 8.9 0.3 2.8 3 0 0 3 3 3 0 Translocation protein Sec62 DUF3573 PF12097.8 ETO34670.1 - 0.023 13.5 1.6 0.024 13.5 0.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) CENP-H PF05837.12 ETO34670.1 - 0.71 10.3 6.6 0.43 11.0 3.5 2.2 1 1 1 2 2 2 0 Centromere protein H (CENP-H) DUF4611 PF15387.6 ETO34670.1 - 1 9.6 5.9 2.7 8.3 5.9 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) WD40 PF00400.32 ETO34671.1 - 3.7e-34 116.2 13.3 7.5e-09 36.1 0.4 5.1 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34671.1 - 6.9e-17 61.5 1.2 0.00099 19.4 0.2 4.1 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO34671.1 - 1.2e-08 34.6 3.5 0.073 13.0 0.0 4.2 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO34671.1 - 4.4e-08 33.2 0.2 0.00023 21.1 0.1 2.0 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO34671.1 - 2.5e-07 30.0 0.0 0.0047 15.9 0.0 3.7 1 1 3 4 4 4 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34671.1 - 6.1e-05 22.5 0.8 0.26 10.6 0.0 2.9 1 1 1 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO34671.1 - 0.00021 20.1 0.7 0.48 9.0 0.0 2.5 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO34671.1 - 0.0015 18.6 0.1 7.8 6.6 0.0 3.0 1 1 2 3 3 3 2 Family of unknown function (DUF5570) DUF2963 PF11178.8 ETO34671.1 - 0.11 12.2 0.0 86 3.0 0.0 4.2 3 1 1 4 4 4 0 Protein of unknown function (DUF2963) FtsX PF02687.21 ETO34673.1 - 1.9e-11 44.3 4.8 1.9e-11 44.3 4.8 2.2 2 0 0 2 2 2 1 FtsX-like permease family LptF_LptG PF03739.14 ETO34673.1 - 0.00033 19.6 3.3 0.00033 19.6 3.3 2.0 2 0 0 2 2 2 1 Lipopolysaccharide export system permease LptF/LptG Pkinase PF00069.25 ETO34675.1 - 5.3e-05 22.7 0.2 8.1e-05 22.1 0.0 1.4 2 0 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34675.1 - 0.0092 15.3 1.0 0.011 15.1 0.0 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Endonuc_Holl PF10107.9 ETO34675.1 - 0.13 12.1 3.2 0.31 10.9 3.2 1.7 1 1 0 1 1 1 0 Endonuclease related to archaeal Holliday junction resolvase Pkinase PF00069.25 ETO34676.1 - 1.7e-31 109.6 0.6 6.2e-22 78.2 0.4 3.0 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34676.1 - 5.1e-12 45.6 0.1 8.1e-10 38.4 0.1 2.4 2 1 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO34676.1 - 4.4e-06 26.2 0.1 6.4e-06 25.7 0.1 1.2 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Kinase-like PF14531.6 ETO34676.1 - 1.6e-05 24.4 0.0 0.031 13.6 0.0 2.2 2 0 0 2 2 2 2 Kinase-like RIO1 PF01163.22 ETO34676.1 - 0.0071 16.0 0.1 0.015 14.9 0.2 1.5 2 0 0 2 2 2 1 RIO1 family APH PF01636.23 ETO34676.1 - 0.0084 16.1 0.0 0.012 15.6 0.0 1.5 1 0 0 1 1 1 1 Phosphotransferase enzyme family Haspin_kinase PF12330.8 ETO34676.1 - 0.011 14.7 0.1 0.014 14.3 0.1 1.2 1 0 0 1 1 1 0 Haspin like kinase domain PIP49_C PF12260.8 ETO34676.1 - 0.052 13.2 0.3 0.17 11.5 0.2 1.8 2 0 0 2 2 2 0 Protein-kinase domain of FAM69 Pox_ser-thr_kin PF05445.11 ETO34676.1 - 0.055 12.4 1.7 1.7 7.5 0.1 2.8 2 1 1 3 3 3 0 Poxvirus serine/threonine protein kinase TryThrA_C PF12319.8 ETO34677.1 - 0.15 11.6 11.9 0.31 10.5 10.7 2.0 1 1 1 2 2 2 0 Tryptophan-Threonine-rich plasmodium antigen C terminal RNase_H PF00075.24 ETO34681.1 - 5.8e-06 26.5 0.1 0.0043 17.2 0.0 3.0 2 1 1 3 3 3 2 RNase H Ion_trans_N PF08412.10 ETO34682.1 - 0.0069 16.0 0.4 0.38 10.4 0.4 2.4 2 0 0 2 2 2 2 Ion transport protein N-terminal NAT PF04768.13 ETO34682.1 - 0.12 12.0 1.4 0.38 10.4 0.1 2.2 2 1 0 2 2 2 0 NAT, N-acetyltransferase, of N-acetylglutamate synthase BsuBI_PstI_RE PF06616.11 ETO34683.1 - 0.092 12.0 0.1 0.18 11.1 0.1 1.5 1 0 0 1 1 1 0 BsuBI/PstI restriction endonuclease domain DUF5577 PF17740.1 ETO34683.1 - 0.097 12.3 0.2 0.13 11.9 0.2 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5577) TRAF6_Z2 PF18048.1 ETO34684.1 - 0.4 10.8 2.9 1 9.5 2.9 1.7 1 0 0 1 1 1 0 TNF receptor-associated factor 6 zinc finger 2 HEAT PF02985.22 ETO34686.1 - 5e-16 57.4 0.5 0.0032 17.6 0.0 9.1 8 0 0 8 8 8 2 HEAT repeat HEAT_2 PF13646.6 ETO34686.1 - 4.8e-11 42.9 0.0 1.6 9.2 0.0 6.1 4 1 0 5 5 5 1 HEAT repeats HEAT_EZ PF13513.6 ETO34686.1 - 2e-09 37.7 0.0 1 10.0 0.0 7.0 6 1 1 7 7 7 1 HEAT-like repeat Cnd1 PF12717.7 ETO34686.1 - 5.9e-09 36.2 31.8 0.00066 19.8 2.4 8.0 2 1 5 7 7 7 4 non-SMC mitotic condensation complex subunit 1 Ank_3 PF13606.6 ETO34686.1 - 1.7e-08 34.1 0.3 0.00016 21.9 0.1 4.4 4 0 0 4 4 2 1 Ankyrin repeat Ank_2 PF12796.7 ETO34686.1 - 6e-08 33.2 0.1 8.8e-07 29.4 0.0 3.2 2 0 0 2 2 1 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO34686.1 - 2.4e-06 27.7 0.1 2e-05 24.8 0.1 2.7 2 1 1 3 3 3 1 Ankyrin repeats (many copies) RTP1_C1 PF10363.9 ETO34686.1 - 5.9e-06 26.4 10.2 3.5 7.8 0.0 7.0 3 3 2 6 6 6 1 Required for nuclear transport of RNA pol II C-terminus 1 Ank_4 PF13637.6 ETO34686.1 - 9.3e-05 22.9 0.3 0.00066 20.2 0.2 2.7 3 0 0 3 3 1 1 Ankyrin repeats (many copies) Ank PF00023.30 ETO34686.1 - 0.00027 21.2 0.0 0.003 17.9 0.0 2.9 2 0 0 2 2 2 1 Ankyrin repeat Vac14_Fab1_bd PF12755.7 ETO34686.1 - 0.0049 17.4 23.9 2.1 9.0 0.0 8.3 5 2 1 8 8 8 1 Vacuolar 14 Fab1-binding region NLE PF08154.12 ETO34686.1 - 0.03 14.9 2.5 11 6.6 0.2 5.1 5 0 0 5 5 4 0 NLE (NUC135) domain Arm-DNA-bind_2 PF12167.8 ETO34686.1 - 0.078 12.9 0.1 31 4.6 0.0 3.1 2 0 0 2 2 2 0 Arm DNA-binding domain UME PF08064.13 ETO34686.1 - 0.079 12.9 0.0 3.6 7.6 0.0 3.8 3 1 0 3 3 3 0 UME (NUC010) domain DNA_pol_E_B PF04042.16 ETO34686.1 - 0.082 12.2 0.0 0.22 10.9 0.0 1.7 1 0 0 1 1 1 0 DNA polymerase alpha/epsilon subunit B GP3_package PF16677.5 ETO34686.1 - 0.24 11.5 1.8 4.3 7.5 0.1 3.4 2 1 1 3 3 3 0 DNA-packaging protein gp3 TIP120 PF08623.10 ETO34686.1 - 0.29 10.9 25.8 1.8 8.3 0.0 7.4 5 2 4 9 9 9 0 TATA-binding protein interacting (TIP20) Spore_IV_A PF09547.10 ETO34686.1 - 0.44 9.4 5.8 0.046 12.7 0.6 2.0 2 0 0 2 2 2 0 Stage IV sporulation protein A (spore_IV_A) Symplekin_C PF12295.8 ETO34686.1 - 0.76 9.8 6.4 9.2 6.3 0.0 4.6 3 2 1 4 4 4 0 Symplekin tight junction protein C terminal Spore_Cse60 PF10957.8 ETO34686.1 - 5.6 7.1 19.5 4.4 7.4 0.2 6.4 6 0 0 6 6 6 0 Sporulation protein Cse60 Kelch_1 PF01344.25 ETO34687.1 - 2.8e-06 26.8 2.2 0.00037 20.0 0.3 3.7 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO34687.1 - 0.002 18.1 0.1 0.26 11.3 0.0 3.4 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO34687.1 - 0.027 14.8 0.8 0.17 12.2 0.0 2.8 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO34687.1 - 0.16 12.0 5.1 0.29 11.2 0.3 3.7 4 1 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO34687.1 - 0.42 10.7 2.1 1.2 9.2 0.3 2.7 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO34688.1 - 1.8e-23 82.3 11.2 1.8e-07 31.7 1.4 3.6 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO34688.1 - 6.9e-09 34.9 3.1 0.0079 14.9 0.2 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34688.1 - 1.3e-08 35.0 0.3 0.0067 16.7 0.1 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34688.1 - 1.9e-05 24.2 0.7 0.0007 19.0 0.4 2.7 1 1 1 2 2 2 1 WD40-like domain HEAT PF02985.22 ETO34689.1 - 8.5e-25 84.7 0.0 0.0013 18.8 0.0 8.2 8 0 0 8 8 8 5 HEAT repeat HEAT_2 PF13646.6 ETO34689.1 - 1.1e-16 61.0 0.0 9.8e-07 29.1 0.0 4.5 1 1 5 6 6 6 4 HEAT repeats RTP1_C1 PF10363.9 ETO34689.1 - 2.9e-11 43.5 0.3 0.0068 16.6 0.0 3.7 1 1 2 3 3 3 3 Required for nuclear transport of RNA pol II C-terminus 1 CLASP_N PF12348.8 ETO34689.1 - 4.4e-10 39.5 3.9 1.2e-05 25.0 0.6 2.8 2 1 1 3 3 3 2 CLASP N terminal Cnd1 PF12717.7 ETO34689.1 - 4.6e-10 39.8 15.5 1.5e-05 25.1 0.3 4.1 1 1 2 3 3 3 2 non-SMC mitotic condensation complex subunit 1 HEAT_EZ PF13513.6 ETO34689.1 - 4.3e-08 33.5 0.0 0.084 13.4 0.0 4.6 4 1 1 5 5 5 2 HEAT-like repeat Vac14_Fab1_bd PF12755.7 ETO34689.1 - 3.5e-07 30.7 5.2 0.2 12.3 0.0 5.1 1 1 5 6 6 6 3 Vacuolar 14 Fab1-binding region TIP120 PF08623.10 ETO34689.1 - 6.7e-06 26.0 9.4 0.87 9.3 0.1 5.3 1 1 5 6 6 6 3 TATA-binding protein interacting (TIP20) Condensin2nSMC PF12422.8 ETO34689.1 - 0.0017 18.6 0.7 0.13 12.4 0.0 3.1 2 1 1 3 3 3 1 Condensin II non structural maintenance of chromosomes subunit V-ATPase_H_N PF03224.14 ETO34689.1 - 0.0035 16.7 3.6 0.084 12.1 0.7 2.6 1 1 1 2 2 2 1 V-ATPase subunit H HEAT_PBS PF03130.16 ETO34689.1 - 0.0038 17.8 0.0 10 7.1 0.0 4.7 5 0 0 5 5 4 0 PBS lyase HEAT-like repeat Spore_III_AB PF09548.10 ETO34689.1 - 0.0051 16.9 4.0 0.062 13.4 0.7 3.1 2 1 1 3 3 3 1 Stage III sporulation protein AB (spore_III_AB) TAN PF11640.8 ETO34689.1 - 0.0067 16.6 4.3 0.022 14.9 1.7 3.2 1 1 1 2 2 2 2 Telomere-length maintenance and DNA damage repair DUF4428 PF14471.6 ETO34689.1 - 0.016 15.1 9.8 0.48 10.4 0.6 3.3 2 1 1 3 3 3 0 Domain of unknown function (DUF4428) Arm-DNA-bind_2 PF12167.8 ETO34689.1 - 0.032 14.1 0.0 11 6.0 0.0 4.1 4 0 0 4 4 4 0 Arm DNA-binding domain Spore_Cse60 PF10957.8 ETO34689.1 - 0.81 9.7 6.6 56 3.9 0.0 4.4 4 0 0 4 4 4 0 Sporulation protein Cse60 gag_pre-integrs PF13976.6 ETO34689.1 - 1.2 9.0 8.0 16 5.5 0.1 4.0 4 0 0 4 4 4 0 GAG-pre-integrase domain Prp18 PF02840.15 ETO34689.1 - 9 6.3 7.5 9.6 6.3 0.1 3.4 4 1 0 4 4 4 0 Prp18 domain Ribosomal_L3 PF00297.22 ETO34691.1 - 2.5e-97 326.2 9.1 2.5e-97 326.2 9.1 3.1 2 1 0 2 2 2 1 Ribosomal protein L3 SpoIIIAH PF12685.7 ETO34691.1 - 0.001 18.9 1.3 0.002 18.0 1.3 1.4 1 0 0 1 1 1 1 SpoIIIAH-like protein DUF4834 PF16118.5 ETO34691.1 - 0.053 14.5 3.9 0.11 13.4 1.9 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) RR_TM4-6 PF06459.12 ETO34691.1 - 0.28 11.0 13.5 0.68 9.7 13.5 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Presenilin PF01080.17 ETO34691.1 - 8.5 5.0 7.1 15 4.2 7.1 1.3 1 0 0 1 1 1 0 Presenilin Kelch_5 PF13854.6 ETO34692.1 - 0.032 14.2 0.0 3 7.9 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Utp12 PF04003.12 ETO34693.1 - 1e-06 29.0 3.3 2.3e-06 27.9 3.3 1.6 1 0 0 1 1 1 1 Dip2/Utp12 Family CLTH PF10607.9 ETO34694.1 - 1.9e-15 57.0 8.0 6.3e-15 55.3 8.0 1.9 1 0 0 1 1 1 1 CTLH/CRA C-terminal to LisH motif domain Beach PF02138.18 ETO34695.1 - 1e-114 382.6 0.1 1.8e-114 381.8 0.1 1.4 1 0 0 1 1 1 1 Beige/BEACH domain FYVE PF01363.21 ETO34695.1 - 2.4e-19 69.2 9.1 4.5e-19 68.4 9.1 1.5 1 0 0 1 1 1 1 FYVE zinc finger PH_BEACH PF14844.6 ETO34695.1 - 1.2e-13 51.0 0.0 2.6e-13 49.9 0.0 1.7 1 0 0 1 1 1 1 PH domain associated with Beige/BEACH WD40 PF00400.32 ETO34695.1 - 2.2e-09 37.8 4.2 5.4e-07 30.2 0.1 4.2 3 1 0 3 3 3 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34695.1 - 2.5e-05 24.5 0.2 0.00089 19.5 0.1 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain IBR PF01485.21 ETO34695.1 - 0.014 15.6 7.5 0.04 14.2 7.5 1.7 1 0 0 1 1 1 0 IBR domain, a half RING-finger domain Ribosomal_S27e PF01667.17 ETO34695.1 - 0.063 13.0 4.5 6.5 6.5 0.0 2.7 2 0 0 2 2 2 0 Ribosomal protein S27 FYVE_2 PF02318.16 ETO34695.1 - 0.11 12.7 6.6 0.32 11.2 6.6 1.7 1 0 0 1 1 1 0 FYVE-type zinc finger zf-RING_5 PF14634.6 ETO34695.1 - 3.7 7.6 10.2 7.3 6.6 10.2 1.5 1 0 0 1 1 1 0 zinc-RING finger domain G-alpha PF00503.20 ETO34697.1 - 1.7e-53 182.1 8.0 4.8e-42 144.4 2.3 2.0 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO34697.1 - 2.5e-06 27.1 0.2 0.0087 15.5 0.1 2.5 2 0 0 2 2 2 2 ADP-ribosylation factor family Rad17 PF03215.15 ETO34697.1 - 0.00088 19.2 0.1 0.0025 17.7 0.0 1.8 2 0 0 2 2 2 1 Rad17 P-loop domain Roc PF08477.13 ETO34697.1 - 0.032 14.4 0.1 0.62 10.3 0.0 2.4 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase TniB PF05621.11 ETO34697.1 - 0.058 12.8 0.0 0.13 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein ABC_tran PF00005.27 ETO34697.1 - 0.22 12.1 0.3 0.37 11.3 0.3 1.5 1 1 0 1 1 1 0 ABC transporter AAA_29 PF13555.6 ETO34697.1 - 0.24 11.2 0.4 0.58 9.9 0.4 1.7 1 1 0 1 1 1 0 P-loop containing region of AAA domain WD40 PF00400.32 ETO34699.1 - 4.6e-14 52.6 11.3 1.3e-06 29.0 1.1 3.8 3 2 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34699.1 - 0.0012 19.0 0.5 1.6 9.1 0.1 2.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34699.1 - 0.003 16.3 0.1 0.019 13.7 0.1 1.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO34699.1 - 0.037 12.6 0.0 0.049 12.2 0.0 1.1 1 0 0 1 1 1 0 Cytochrome D1 heme domain TPR_12 PF13424.6 ETO34700.1 - 2.6e-34 117.3 1.4 3.7e-16 59.2 0.0 4.3 1 1 4 5 5 5 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO34700.1 - 7.2e-25 86.1 0.0 1.6e-07 30.9 0.0 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34700.1 - 8.8e-15 53.8 17.4 1e-06 28.3 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34700.1 - 6.3e-12 44.7 18.6 7.9e-05 22.6 0.1 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34700.1 - 1.9e-11 43.2 8.2 0.0013 18.6 0.0 4.7 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34700.1 - 5.4e-11 41.7 0.5 0.71 10.0 0.0 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO34700.1 - 4.6e-06 26.6 1.2 0.15 12.5 0.0 4.0 4 0 0 4 4 3 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO34700.1 - 0.024 14.0 0.0 0.036 13.4 0.0 1.4 1 1 0 1 1 1 0 MalT-like TPR region HDV_ag PF01517.18 ETO34700.1 - 0.054 13.3 0.4 0.4 10.4 0.1 2.0 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen ILEI PF15711.5 ETO34700.1 - 0.13 12.8 0.0 5.8 7.5 0.0 2.6 2 1 0 2 2 2 0 Interleukin-like EMT inducer TPR_6 PF13174.6 ETO34700.1 - 0.21 12.3 0.6 21 6.0 0.2 3.7 4 2 0 4 4 4 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO34700.1 - 2.4 7.9 7.3 37 4.1 0.1 4.2 4 1 1 5 5 5 0 TPR repeat WD40 PF00400.32 ETO34701.1 - 9.4e-40 133.9 25.5 5.6e-08 33.3 0.7 7.0 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34701.1 - 2.1e-12 47.2 0.7 0.12 12.7 0.0 5.8 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34701.1 - 4.3e-12 45.5 2.8 0.0088 14.7 0.1 4.4 2 2 2 4 4 4 4 Nucleoporin Nup120/160 TetM_leader PF08076.11 ETO34701.1 - 0.13 12.0 1.9 4.7 7.1 0.1 3.1 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide HrpE PF06188.12 ETO34702.1 - 0.043 13.7 0.3 0.076 12.9 0.3 1.3 1 0 0 1 1 1 0 HrpE/YscL/FliH and V-type ATPase subunit E DUF3375 PF11855.8 ETO34702.1 - 0.095 11.6 0.0 0.12 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3375) DUF1773 PF08593.10 ETO34702.1 - 0.11 13.5 0.5 0.71 11.0 0.5 2.5 1 1 0 1 1 1 0 Domain of unknown function DivIVA PF05103.13 ETO34702.1 - 0.32 11.1 3.6 0.56 10.3 3.6 1.3 1 0 0 1 1 1 0 DivIVA protein Leu_zip PF15294.6 ETO34703.1 - 0.00058 19.5 1.3 0.00069 19.2 1.3 1.2 1 0 0 1 1 1 1 Leucine zipper SAM_1 PF00536.30 ETO34703.1 - 0.0011 19.3 0.6 0.0032 17.9 0.6 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Phage_GP20 PF06810.11 ETO34703.1 - 0.0014 18.4 1.3 0.0014 18.4 1.3 1.6 2 0 0 2 2 2 1 Phage minor structural protein GP20 NEMO PF11577.8 ETO34703.1 - 0.0016 18.4 2.0 0.0033 17.4 2.0 1.5 1 0 0 1 1 1 1 NF-kappa-B essential modulator NEMO DivIVA PF05103.13 ETO34703.1 - 0.0048 17.0 1.6 0.0048 17.0 1.6 1.7 2 0 0 2 2 2 1 DivIVA protein DUF3226 PF11536.8 ETO34703.1 - 0.0074 16.0 0.1 0.0096 15.6 0.1 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF3226) PepSY PF03413.19 ETO34703.1 - 0.012 16.2 1.0 0.025 15.2 1.0 1.5 1 0 0 1 1 1 0 Peptidase propeptide and YPEB domain Sec34 PF04136.15 ETO34703.1 - 0.013 15.3 0.5 0.047 13.6 0.1 1.9 2 0 0 2 2 2 0 Sec34-like family Snf7 PF03357.21 ETO34703.1 - 0.024 14.2 1.8 0.024 14.2 1.8 1.5 2 0 0 2 2 2 0 Snf7 SopE_GEF PF07487.13 ETO34703.1 - 0.025 14.7 0.0 0.058 13.5 0.0 1.6 1 1 0 1 1 1 0 SopE GEF domain DUF2229 PF09989.9 ETO34703.1 - 0.033 13.8 0.1 0.038 13.6 0.1 1.2 1 0 0 1 1 1 0 CoA enzyme activase uncharacterised domain (DUF2229) NAD_binding_5 PF07994.12 ETO34703.1 - 0.06 12.7 0.7 0.077 12.4 0.3 1.4 2 0 0 2 2 2 0 Myo-inositol-1-phosphate synthase IFP_35_N PF07334.13 ETO34703.1 - 0.11 12.5 5.1 0.25 11.4 5.1 1.6 1 0 0 1 1 1 0 Interferon-induced 35 kDa protein (IFP 35) N-terminus UPF0242 PF06785.11 ETO34703.1 - 1.8 8.6 6.8 2.7 8.1 6.8 1.4 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus Speriolin_N PF15058.6 ETO34703.1 - 3.6 7.6 4.5 5.3 7.1 1.7 2.2 2 1 0 2 2 2 0 Speriolin N terminus SAM_1 PF00536.30 ETO34704.1 - 1.1e-08 35.3 1.7 2.6e-08 34.2 0.3 2.4 2 0 0 2 2 2 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO34704.1 - 1.4e-08 34.7 0.2 3.8e-08 33.3 0.2 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) DUF3792 PF12670.7 ETO34704.1 - 0.19 11.9 0.0 0.31 11.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3792) Wyosine_form PF08608.12 ETO34704.1 - 0.88 10.0 3.8 4.8 7.6 0.2 3.0 2 1 1 3 3 3 0 Wyosine base formation N2227 PF07942.12 ETO34704.1 - 1.6 7.8 9.7 2.7 7.1 0.1 3.2 2 1 1 3 3 3 0 N2227-like protein ARGLU PF15346.6 ETO34704.1 - 1.8 8.4 38.7 0.14 12.1 0.4 3.3 2 1 0 3 3 3 0 Arginine and glutamate-rich 1 ERM PF00769.19 ETO34706.1 - 0.00057 19.8 6.3 0.00057 19.8 6.3 2.7 3 0 0 3 3 3 1 Ezrin/radixin/moesin family Toxin_R_bind_C PF07951.12 ETO34706.1 - 0.03 14.0 1.6 0.19 11.4 0.0 2.5 2 0 0 2 2 2 0 Clostridium neurotoxin, C-terminal receptor binding DUF1515 PF07439.11 ETO34706.1 - 0.1 12.6 0.6 0.25 11.4 0.6 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1515) DivIC PF04977.15 ETO34706.1 - 1.9 8.3 4.7 1.6 8.5 2.2 2.3 2 0 0 2 2 2 0 Septum formation initiator Csm1_N PF18504.1 ETO34706.1 - 3.3 8.1 10.9 0.24 11.8 1.1 3.5 3 0 0 3 3 3 0 Csm1 N-terminal domain CAP PF00188.26 ETO34707.1 - 4.3e-11 43.7 9.1 4.3e-11 43.7 9.1 2.7 2 1 1 3 3 3 1 Cysteine-rich secretory protein family TMEM154 PF15102.6 ETO34707.1 - 0.16 11.9 0.0 0.16 11.9 0.0 2.6 2 1 0 2 2 2 0 TMEM154 protein family Pox_EPC_I2-L1 PF12575.8 ETO34707.1 - 0.16 12.2 0.0 0.42 10.9 0.0 1.6 1 0 0 1 1 1 0 Poxvirus entry protein complex L1 and I2 WBP-1 PF11669.8 ETO34707.1 - 0.19 12.4 0.1 0.19 12.4 0.1 2.3 2 0 0 2 2 2 0 WW domain-binding protein 1 RF-1 PF00472.20 ETO34708.1 - 8.4e-17 61.2 1.0 1.1e-16 60.9 0.3 1.5 1 1 1 2 2 2 1 RF-1 domain FKBP_C PF00254.28 ETO34708.1 - 0.0082 16.4 0.1 0.12 12.7 0.0 2.2 2 0 0 2 2 2 1 FKBP-type peptidyl-prolyl cis-trans isomerase DDE_Tnp_2 PF04693.12 ETO34708.1 - 0.13 11.4 4.0 0.7 9.1 0.7 2.4 2 1 1 3 3 3 0 Archaeal putative transposase ISC1217 Ly49 PF08391.10 ETO34709.1 - 0.03 14.7 4.0 0.047 14.0 4.0 1.3 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region YMF19 PF02326.15 ETO34709.1 - 0.041 14.7 3.5 0.041 14.7 3.5 2.3 1 1 1 2 2 2 0 Plant ATP synthase F0 YflT PF11181.8 ETO34710.1 - 1.8 9.1 9.9 0.44 11.1 3.4 2.8 2 1 1 3 3 3 0 Heat induced stress protein YflT Gal_Lectin PF02140.18 ETO34712.1 - 7.7e-17 61.5 1.9 1.7e-16 60.4 1.9 1.6 1 0 0 1 1 1 1 Galactose binding lectin domain Glyco_hydro_39 PF01229.17 ETO34712.1 - 0.00014 20.7 1.1 0.00025 19.8 1.1 1.4 1 0 0 1 1 1 1 Glycosyl hydrolases family 39 HEAT PF02985.22 ETO34713.1 - 2.5e-08 33.5 0.1 6.7e-06 25.9 0.0 3.5 3 0 0 3 3 3 1 HEAT repeat HEAT_EZ PF13513.6 ETO34713.1 - 7.1e-08 32.8 0.0 1.7e-06 28.4 0.0 3.3 4 0 0 4 4 4 1 HEAT-like repeat Adaptin_N PF01602.20 ETO34713.1 - 0.00018 20.2 1.4 0.0085 14.7 0.0 2.7 3 0 0 3 3 3 2 Adaptin N terminal region Cnd1 PF12717.7 ETO34713.1 - 0.0024 17.9 1.3 0.026 14.6 0.0 3.0 3 1 0 3 3 3 1 non-SMC mitotic condensation complex subunit 1 HEAT_2 PF13646.6 ETO34713.1 - 0.022 15.2 0.0 0.12 12.7 0.0 2.3 1 1 0 1 1 1 0 HEAT repeats Arm PF00514.23 ETO34713.1 - 0.026 14.6 0.1 0.27 11.3 0.0 3.0 3 0 0 3 3 3 0 Armadillo/beta-catenin-like repeat RIH_assoc PF08454.11 ETO34713.1 - 0.062 13.1 7.1 1.6 8.6 0.1 4.0 2 2 0 2 2 2 0 RyR and IP3R Homology associated DUF1798 PF08807.10 ETO34713.1 - 0.085 13.0 0.6 0.23 11.6 0.2 1.9 2 0 0 2 2 2 0 Bacterial domain of unknown function (DUF1798) SLT_2 PF13406.6 ETO34713.1 - 0.15 11.3 0.3 0.27 10.4 0.3 1.3 1 0 0 1 1 1 0 Transglycosylase SLT domain Orf78 PF06024.12 ETO34714.1 - 0.0076 16.5 0.2 0.015 15.6 0.2 1.4 1 0 0 1 1 1 1 Orf78 (ac78) DUF3236 PF11576.8 ETO34714.1 - 0.013 15.2 0.2 0.021 14.5 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3236) RIFIN PF02009.16 ETO34714.1 - 0.03 14.2 0.4 0.041 13.8 0.4 1.2 1 0 0 1 1 1 0 Rifin COX2_TM PF02790.15 ETO34714.1 - 0.031 14.4 1.3 0.047 13.8 0.6 1.8 2 0 0 2 2 2 0 Cytochrome C oxidase subunit II, transmembrane domain DUF5385 PF17359.2 ETO34714.1 - 0.12 11.9 0.8 0.19 11.3 0.8 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5385) Synaptobrevin PF00957.21 ETO34714.1 - 0.51 10.2 5.6 1.1 9.1 2.0 2.4 2 0 0 2 2 2 0 Synaptobrevin WD40 PF00400.32 ETO34715.1 - 6.8e-25 86.9 3.8 4.6e-08 33.6 0.5 4.1 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO34715.1 - 6.9e-06 25.0 0.2 0.02 13.6 0.0 2.6 1 1 2 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34715.1 - 5.5e-05 23.4 0.1 2.3 8.6 0.0 3.1 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Mid2 PF04478.12 ETO34715.1 - 0.00038 20.3 0.6 0.0016 18.3 0.1 2.0 2 0 0 2 2 2 1 Mid2 like cell wall stress sensor WD40_like PF17005.5 ETO34715.1 - 0.0013 18.2 1.3 0.04 13.2 0.0 2.1 1 1 0 2 2 2 1 WD40-like domain DUF5626 PF18540.1 ETO34715.1 - 0.018 15.6 1.1 0.23 12.0 1.1 2.1 1 1 0 1 1 1 0 Domain of unknown function (DUF5626) HARP PF07443.13 ETO34715.1 - 0.027 14.1 0.8 0.37 10.4 0.0 2.7 3 0 0 3 3 3 0 HepA-related protein (HARP) nos_propeller PF18764.1 ETO34715.1 - 0.069 13.1 0.0 24 4.9 0.0 3.1 3 0 0 3 3 3 0 Nitrous oxide reductase propeller repeat PD40 PF07676.12 ETO34715.1 - 0.1 12.6 0.1 41 4.3 0.0 3.1 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO34715.1 - 0.22 11.6 3.0 1.2 9.3 0.1 2.7 2 1 1 3 3 3 0 Family of unknown function (DUF5474) zf-RING_2 PF13639.6 ETO34716.1 - 0.019 15.3 1.6 0.075 13.4 0.8 2.4 1 1 1 2 2 2 0 Ring finger domain zf-C3HC4_2 PF13923.6 ETO34716.1 - 3.3 7.6 10.0 0.3 11.0 3.0 2.8 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO34716.1 - 3.6 8.0 8.4 8 6.9 0.8 2.8 2 1 1 3 3 3 0 RING-like domain WD40 PF00400.32 ETO34717.1 - 7.9e-08 32.9 2.2 1.6e-07 31.9 2.2 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat DUF603 PF04645.12 ETO34717.1 - 0.048 13.4 9.9 0.025 14.3 7.0 1.9 1 1 1 2 2 2 0 Protein of unknown function, DUF603 DUF4407 PF14362.6 ETO34717.1 - 0.084 12.2 5.4 0.12 11.7 5.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) EOS1 PF12326.8 ETO34717.1 - 0.71 9.8 2.6 1.2 9.1 2.6 1.4 1 0 0 1 1 1 0 N-glycosylation protein Golgin_A5 PF09787.9 ETO34717.1 - 2.3 7.6 25.4 0.084 12.3 16.9 2.0 2 0 0 2 2 2 0 Golgin subfamily A member 5 DUF3573 PF12097.8 ETO34717.1 - 6.6 5.4 13.3 4.4 6.0 12.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3573) Vfa1 PF08432.10 ETO34717.1 - 7.6 6.8 18.5 16 5.8 18.5 1.5 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 TRAM_LAG1_CLN8 PF03798.16 ETO34718.1 - 9.9e-10 38.5 6.3 2.8e-09 37.0 6.3 1.7 1 1 0 1 1 1 1 TLC domain EF-hand_7 PF13499.6 ETO34720.1 - 3.4e-16 59.4 10.3 1.8e-14 53.9 3.8 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO34720.1 - 1.4e-12 46.2 10.4 1.3e-05 24.4 1.6 4.0 4 0 0 4 4 4 3 EF hand EF-hand_6 PF13405.6 ETO34720.1 - 1.8e-11 43.0 8.5 0.00015 21.4 0.1 4.2 5 0 0 5 5 5 3 EF-hand domain EF-hand_8 PF13833.6 ETO34720.1 - 2e-09 37.1 6.5 2.1e-09 37.1 1.0 2.9 3 1 1 4 4 4 2 EF-hand domain pair EF-hand_9 PF14658.6 ETO34720.1 - 4.8e-08 33.2 0.4 2.1e-07 31.1 0.1 2.0 2 0 0 2 2 2 1 EF-hand domain EF-hand_5 PF13202.6 ETO34720.1 - 1.6e-05 24.2 5.0 0.0088 15.5 0.9 3.0 3 0 0 3 3 3 2 EF hand EF-hand_14 PF17959.1 ETO34720.1 - 0.046 14.1 1.1 0.11 12.9 0.4 1.9 2 0 0 2 2 2 0 EF-hand domain DUF4834 PF16118.5 ETO34720.1 - 0.11 13.5 4.1 2.1 9.3 0.2 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) 7tm_1 PF00001.21 ETO34721.1 - 0.85 8.9 11.3 0.41 9.9 8.0 2.1 1 1 0 1 1 1 0 7 transmembrane receptor (rhodopsin family) Jagunal PF07086.12 ETO34721.1 - 0.85 9.7 5.9 0.3 11.1 2.0 2.1 1 1 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis Orthoreo_P10 PF07204.11 ETO34721.1 - 0.96 9.4 4.5 9.2 6.3 0.2 2.9 3 1 0 3 3 3 0 Orthoreovirus membrane fusion protein p10 B56 PF01603.20 ETO34722.1 - 8.9e-94 314.8 19.8 1e-92 311.3 19.8 2.5 1 1 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) TRP PF06011.12 ETO34722.1 - 0.11 11.2 1.6 0.5 9.0 0.3 2.1 2 0 0 2 2 2 0 Transient receptor potential (TRP) ion channel 2OG-FeII_Oxy PF03171.20 ETO34724.1 - 1.5e-05 25.4 0.1 4.1e-05 24.0 0.1 1.7 2 0 0 2 2 2 1 2OG-Fe(II) oxygenase superfamily DIOX_N PF14226.6 ETO34724.1 - 0.00021 22.0 0.1 0.00047 20.9 0.1 1.5 1 0 0 1 1 1 1 non-haem dioxygenase in morphine synthesis N-terminal RRM_1 PF00076.22 ETO34725.1 - 4.6e-15 55.2 1.1 1.9e-14 53.2 0.1 2.2 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO34725.1 - 0.021 14.8 0.1 0.043 13.8 0.1 1.5 1 0 0 1 1 1 0 Nup53/35/40-type RNA recognition motif DUF4820 PF16091.5 ETO34725.1 - 0.029 13.7 0.0 0.037 13.4 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) EcoRI_methylase PF13651.6 ETO34726.1 - 0.00015 21.1 6.5 0.00019 20.8 6.5 1.1 1 0 0 1 1 1 1 Adenine-specific methyltransferase EcoRI DUF2072 PF09845.9 ETO34726.1 - 0.011 16.0 1.4 0.011 16.0 1.4 1.3 2 0 0 2 2 2 0 Zn-ribbon containing protein Rsc14 PF08586.10 ETO34726.1 - 0.21 12.4 4.4 1.1 10.0 4.4 2.0 1 1 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Beta-lactamase PF00144.24 ETO34728.1 - 2.4e-33 115.8 0.0 3.2e-33 115.4 0.0 1.0 1 0 0 1 1 1 1 Beta-lactamase Peptidase_S11 PF00768.20 ETO34728.1 - 0.0011 18.4 0.0 0.0049 16.3 0.0 1.9 2 0 0 2 2 2 1 D-alanyl-D-alanine carboxypeptidase Beta-lactamase2 PF13354.6 ETO34728.1 - 0.18 11.4 0.0 5.9 6.4 0.0 2.2 2 0 0 2 2 2 0 Beta-lactamase enzyme family WD40 PF00400.32 ETO34730.1 - 6.9e-14 52.0 6.4 3.9e-08 33.8 0.7 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO34730.1 - 1.8e-05 23.6 0.5 0.013 14.2 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34730.1 - 0.0071 15.7 1.1 0.0071 15.7 1.1 1.8 2 1 0 2 2 2 1 WD40-like domain HARP PF07443.13 ETO34730.1 - 0.091 12.4 2.1 2.7 7.7 0.1 2.7 3 0 0 3 3 3 0 HepA-related protein (HARP) WD40 PF00400.32 ETO34731.1 - 1.3e-117 380.3 56.7 9.9e-10 38.9 0.9 16.0 14 2 1 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34731.1 - 6.2e-37 125.8 16.9 0.0025 18.1 0.0 13.1 1 1 13 14 14 14 12 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34731.1 - 3.8e-20 72.4 18.5 0.00025 20.5 0.2 7.6 3 1 4 8 8 8 7 WD40-like domain Ge1_WD40 PF16529.5 ETO34731.1 - 1.9e-17 63.2 1.0 0.93 8.4 0.0 10.8 1 1 7 9 9 9 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO34731.1 - 1.1e-06 28.1 2.3 2.8e-06 26.8 2.3 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) NACHT PF05729.12 ETO34731.1 - 2.1e-05 24.5 0.0 4.6e-05 23.4 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide_4 PF13599.6 ETO34731.1 - 9.2e-05 22.5 0.6 0.00034 20.7 0.6 2.0 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO34731.1 - 0.0014 18.8 0.9 0.0039 17.3 0.9 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO34731.1 - 0.0042 17.0 14.7 29 4.7 0.0 8.5 10 0 0 10 10 9 0 WD40-like Beta Propeller Repeat TolB_N PF04052.13 ETO34731.1 - 0.0069 16.5 0.1 70 3.7 0.0 6.4 8 0 0 8 8 8 0 TolB amino-terminal domain DUF5570 PF17731.1 ETO34731.1 - 0.01 15.9 11.4 1.7 8.8 0.1 6.7 5 3 1 6 6 6 0 Family of unknown function (DUF5570) AAA_18 PF13238.6 ETO34731.1 - 0.02 15.5 0.4 0.1 13.1 0.0 2.4 2 0 0 2 2 2 0 AAA domain WD40 PF00400.32 ETO34732.1 - 1.9e-11 44.3 4.9 3.1e-06 27.8 0.3 2.7 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO34732.1 - 0.00017 20.4 0.8 0.15 10.7 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO34732.1 - 0.00047 19.8 4.6 0.0022 17.6 4.6 1.8 1 1 0 1 1 1 1 Domain of unknown function (DUF4221) ANAPC4_WD40 PF12894.7 ETO34732.1 - 0.0028 17.9 0.1 0.024 14.9 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain MFAP1 PF06991.11 ETO34733.1 - 5.9e-41 140.7 32.5 5.9e-41 140.7 32.5 4.4 2 1 1 3 3 3 1 Microfibril-associated/Pre-mRNA processing PRP38_assoc PF12871.7 ETO34733.1 - 0.0094 16.5 29.8 0.0094 16.5 29.8 7.1 3 1 2 6 6 6 1 Pre-mRNA-splicing factor 38-associated hydrophilic C-term Kelch_3 PF13415.6 ETO34734.1 - 2.5e-05 24.4 0.2 0.0011 19.1 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO34734.1 - 3.3e-05 24.0 1.4 0.044 14.1 0.1 3.8 3 1 1 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO34734.1 - 7.5e-05 22.7 0.1 0.41 10.7 0.0 4.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO34734.1 - 0.00071 19.5 0.1 0.55 10.3 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO34734.1 - 0.019 14.5 1.3 0.21 11.2 0.0 3.1 3 0 0 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETO34734.1 - 0.024 14.6 1.7 0.41 10.7 0.6 3.3 4 0 0 4 4 4 0 Kelch motif Peptidase_C14 PF00656.22 ETO34735.1 - 3e-10 40.5 0.7 4.1e-10 40.0 0.7 1.2 1 0 0 1 1 1 1 Caspase domain DUF1366 PF07104.11 ETO34735.1 - 0.052 13.3 0.0 0.12 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1366) Phtf-FEM1B_bdg PF12129.8 ETO34735.1 - 0.082 12.7 0.0 2.3 8.1 0.0 2.3 2 0 0 2 2 2 0 Male germ-cell putative homeodomain transcription factor DnaJ PF00226.31 ETO34736.1 - 1e-22 80.0 1.5 1.4e-22 79.5 1.5 1.2 1 0 0 1 1 1 1 DnaJ domain Tubulin PF00091.25 ETO34736.1 - 5.6 7.1 11.0 3.7 7.7 0.1 2.2 1 1 1 2 2 2 0 Tubulin/FtsZ family, GTPase domain DHC_N1 PF08385.12 ETO34737.1 - 2.4e-31 109.0 15.4 3.2e-31 108.6 15.4 1.2 1 0 0 1 1 1 1 Dynein heavy chain, N-terminal region 1 Resolvase PF00239.21 ETO34737.1 - 0.005 17.0 0.8 0.005 17.0 0.8 3.0 3 0 0 3 3 3 1 Resolvase, N terminal domain zf-RING_9 PF13901.6 ETO34737.1 - 0.23 11.4 6.6 0.57 10.1 3.2 2.5 2 0 0 2 2 2 0 Putative zinc-RING and/or ribbon PCRF PF03462.18 ETO34737.1 - 0.61 9.9 10.6 0.37 10.6 3.8 2.6 2 0 0 2 2 2 0 PCRF domain DUF2779 PF11074.8 ETO34737.1 - 0.66 10.5 3.3 1.1 9.7 0.3 2.9 3 1 0 3 3 3 0 Domain of unknown function(DUF2779) WD40 PF00400.32 ETO34738.1 - 1.1e-10 41.9 2.9 3.8e-07 30.7 0.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34738.1 - 0.024 14.9 0.0 0.035 14.4 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO34739.1 - 2.2e-06 28.2 0.8 2.2e-06 28.2 0.8 2.5 3 0 0 3 3 3 1 TRAF-type zinc finger Nodulin_late PF07127.11 ETO34740.1 - 0.36 11.2 3.3 0.43 10.9 0.1 2.3 2 0 0 2 2 2 0 Late nodulin protein PUB PF09409.10 ETO34741.1 - 0.0016 18.3 2.1 0.022 14.7 2.1 2.5 1 1 0 1 1 1 1 PUB domain Rgp1 PF08737.10 ETO34742.1 - 0.031 13.5 4.3 0.056 12.6 4.3 1.3 1 1 0 1 1 1 0 Rgp1 DUF4576 PF15144.6 ETO34742.1 - 0.19 11.6 0.6 0.29 11.0 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4576) 14-3-3 PF00244.20 ETO34742.1 - 0.2 11.2 4.4 0.28 10.7 4.4 1.1 1 0 0 1 1 1 0 14-3-3 protein Rad54_N PF08658.10 ETO34742.1 - 0.25 11.5 3.1 0.38 10.9 3.1 1.2 1 0 0 1 1 1 0 Rad54 N terminal DUF4407 PF14362.6 ETO34742.1 - 2.2 7.5 3.5 2.7 7.3 3.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Spore_GerAC PF05504.11 ETO34742.1 - 5.7 7.1 11.6 6.2 7.0 10.5 1.5 1 1 1 2 2 2 0 Spore germination B3/ GerAC like, C-terminal BRI3BP PF14965.6 ETO34743.1 - 0.041 13.4 0.3 0.058 12.9 0.3 1.2 1 0 0 1 1 1 0 Negative regulator of p53/TP53 ALMT PF11744.8 ETO34744.1 - 0.0099 14.8 3.4 0.012 14.4 3.4 1.0 1 0 0 1 1 1 1 Aluminium activated malate transporter Presenilin PF01080.17 ETO34744.1 - 1.8 7.2 3.6 2.3 6.9 3.6 1.1 1 0 0 1 1 1 0 Presenilin Prp18 PF02840.15 ETO34744.1 - 3 7.9 7.0 36 4.4 4.0 2.2 2 0 0 2 2 2 0 Prp18 domain WD40 PF00400.32 ETO34745.1 - 3.1e-37 125.9 23.7 1.6e-06 28.7 0.6 8.0 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO34745.1 - 5.6e-12 45.1 4.3 0.57 8.8 0.0 5.9 2 2 3 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34745.1 - 2.4e-09 37.4 2.3 0.89 9.9 0.0 5.6 2 2 2 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO34745.1 - 0.00019 21.4 3.4 3.8 7.6 0.2 4.3 3 2 0 3 3 3 3 Ciliary BBSome complex subunit 2, middle region SBP56 PF05694.11 ETO34745.1 - 0.02 13.7 0.1 1.9 7.2 0.1 2.3 2 0 0 2 2 2 0 56kDa selenium binding protein (SBP56) Nucleoporin_N PF08801.11 ETO34745.1 - 0.022 13.5 5.8 0.75 8.5 0.1 3.8 3 1 0 3 3 3 0 Nup133 N terminal like HEAT PF02985.22 ETO34746.1 - 8.7e-29 97.1 8.3 0.0053 16.9 0.0 9.6 9 0 0 9 9 9 8 HEAT repeat HEAT_2 PF13646.6 ETO34746.1 - 1.1e-18 67.4 1.9 8.4e-06 26.1 0.1 5.9 3 1 3 6 6 6 3 HEAT repeats Cnd1 PF12717.7 ETO34746.1 - 2.8e-09 37.2 3.2 0.037 14.1 0.0 5.5 2 1 3 6 6 6 3 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO34746.1 - 8.8e-08 32.6 0.0 0.3 11.7 0.0 4.4 2 1 2 4 4 4 3 Vacuolar 14 Fab1-binding region Adaptin_N PF01602.20 ETO34746.1 - 0.00013 20.7 3.0 0.42 9.1 0.0 3.8 1 1 2 3 3 3 3 Adaptin N terminal region HEAT_EZ PF13513.6 ETO34746.1 - 0.00016 22.1 0.3 0.033 14.7 0.0 4.3 6 0 0 6 6 6 1 HEAT-like repeat CLASP_N PF12348.8 ETO34746.1 - 0.00032 20.3 4.3 9.4 5.7 0.1 5.3 3 2 2 5 5 5 2 CLASP N terminal Cohesin_HEAT PF12765.7 ETO34746.1 - 0.011 16.0 2.3 1.1 9.7 0.0 4.1 5 0 0 5 5 5 0 HEAT repeat associated with sister chromatid cohesion RasGEF_N_2 PF14663.6 ETO34746.1 - 0.13 12.7 0.0 13 6.3 0.0 3.2 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Cytadhesin_P30 PF07271.11 ETO34747.1 - 0.016 14.8 0.1 0.027 14.0 0.1 1.3 1 0 0 1 1 1 0 Cytadhesin P30/P32 WD40 PF00400.32 ETO34748.1 - 8.7e-36 121.3 19.4 4.8e-06 27.2 0.5 7.3 6 0 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO34748.1 - 6.9e-16 58.0 6.4 0.01 14.5 0.1 6.4 1 1 5 6 6 6 6 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34748.1 - 8.4e-11 42.0 2.2 0.005 17.1 0.1 5.8 2 2 3 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO34748.1 - 2.1e-07 31.5 1.3 2.1e-07 31.5 1.3 2.5 2 1 0 2 2 2 1 TRAF-type zinc finger DUF1541 PF07563.11 ETO34748.1 - 0.21 11.5 0.2 1.2e+02 2.7 0.0 3.9 5 0 0 5 5 5 0 Protein of unknown function (DUF1541) TPR_12 PF13424.6 ETO34750.1 - 0.00048 20.4 0.0 0.035 14.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34750.1 - 0.0062 16.6 1.0 0.032 14.4 0.5 2.3 2 0 0 2 2 2 1 Tetratricopeptide repeat DASH_Dam1 PF08653.10 ETO34750.1 - 0.047 13.5 0.0 0.11 12.3 0.0 1.6 1 0 0 1 1 1 0 DASH complex subunit Dam1 TPR_1 PF00515.28 ETO34750.1 - 0.16 11.9 0.8 0.87 9.5 0.6 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat 7tm_3 PF00003.22 ETO34751.1 - 0.00044 20.1 1.1 0.00069 19.4 1.1 1.3 1 0 0 1 1 1 1 7 transmembrane sweet-taste receptor of 3 GCPR DUF4864 PF16156.5 ETO34752.1 - 6.9e-06 26.7 0.0 1.3e-05 25.8 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4864) F-box PF00646.33 ETO34752.1 - 1.1e-05 25.2 1.7 1.1e-05 25.2 1.7 1.9 2 0 0 2 2 2 1 F-box domain F-box-like PF12937.7 ETO34752.1 - 7.1e-05 22.6 1.8 0.00014 21.7 1.8 1.5 1 0 0 1 1 1 1 F-box-like LRR_4 PF12799.7 ETO34752.1 - 0.045 14.2 0.9 0.11 13.0 0.1 2.0 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) dDENN PF03455.19 ETO34754.1 - 0.39 10.8 4.2 0.88 9.6 0.2 2.4 1 1 1 2 2 2 0 dDENN domain DUF92 PF01940.16 ETO34755.1 - 2e-40 138.7 9.4 1.5e-39 135.8 9.4 1.9 1 1 0 1 1 1 1 Integral membrane protein DUF92 AUDH_Cupin PF18637.1 ETO34756.1 - 0.041 13.9 0.6 0.072 13.1 0.6 1.5 1 0 0 1 1 1 0 Aldos-2-ulose dehydratase/isomerase (AUDH) Cupin domain Sigma_reg_N PF13800.6 ETO34756.1 - 0.11 12.8 0.3 0.23 11.8 0.3 1.5 1 1 0 1 1 1 0 Sigma factor regulator N-terminal Methyltransf_21 PF05050.12 ETO34757.1 - 2.4e-06 27.7 0.3 7.2e-06 26.1 0.3 1.9 1 1 0 1 1 1 1 Methyltransferase FkbM domain CHORD PF04968.12 ETO34757.1 - 0.097 13.4 0.3 0.23 12.2 0.3 1.6 1 0 0 1 1 1 0 CHORD ELH PF02323.15 ETO34758.1 - 0.0072 15.7 4.0 0.013 14.9 4.0 1.4 1 0 0 1 1 1 1 Egg-laying hormone precursor PWWP PF00855.17 ETO34759.1 - 1.2e-07 32.0 1.2 0.0019 18.5 0.1 3.5 3 0 0 3 3 3 2 PWWP domain Phospholip_B PF04916.13 ETO34760.1 - 4.7e-15 55.2 3.2 7.7e-15 54.5 3.2 1.3 1 1 0 1 1 1 1 Phospholipase B Phage_holin_2_2 PF10746.9 ETO34760.1 - 0.1 12.3 0.6 0.28 10.9 0.2 1.8 2 0 0 2 2 2 0 Phage holin T7 family, holin superfamily II NAD_kinase PF01513.21 ETO34761.1 - 3.3e-39 134.9 0.2 6.4e-39 133.9 0.1 1.5 2 0 0 2 2 2 1 ATP-NAD kinase WD40 PF00400.32 ETO34762.1 - 2.1e-28 98.0 14.9 1.8e-06 28.5 0.5 6.6 6 1 0 6 6 6 5 WD domain, G-beta repeat WD40_like PF17005.5 ETO34762.1 - 4.5e-06 26.2 2.7 0.1 11.9 0.1 3.5 2 1 1 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 ETO34762.1 - 8.7e-06 26.0 0.2 0.43 10.9 0.0 4.3 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34762.1 - 0.00016 20.5 4.2 0.8 8.3 0.0 3.9 2 2 3 5 5 5 3 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO34762.1 - 0.032 14.5 2.0 2 8.6 0.5 2.5 1 1 1 2 2 2 0 Domain of unknown function (DUF4979) Ricin_B_lectin PF00652.22 ETO34762.1 - 3.9 7.7 7.5 4.4 7.6 2.6 2.4 2 0 0 2 2 2 0 Ricin-type beta-trefoil lectin domain PBP1_TM PF14812.6 ETO34763.1 - 2 8.8 11.6 8.5 6.8 5.5 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal PPR_2 PF13041.6 ETO34765.1 - 0.088 13.0 0.0 0.33 11.2 0.0 2.1 1 0 0 1 1 1 0 PPR repeat family Dus PF01207.17 ETO34766.1 - 3.5e-35 121.6 0.1 4.1e-35 121.4 0.1 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) Dus PF01207.17 ETO34767.1 - 7.7e-15 54.8 0.0 1.1e-14 54.3 0.0 1.2 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) TrwC PF08751.11 ETO34767.1 - 0.22 11.0 0.0 0.39 10.2 0.0 1.2 1 1 0 1 1 1 0 TrwC relaxase DUF4658 PF15555.6 ETO34768.1 - 0.1 12.7 0.3 0.23 11.6 0.3 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4658) Ank_2 PF12796.7 ETO34769.1 - 5.3e-05 23.7 0.1 0.058 14.0 0.0 2.0 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO34769.1 - 0.0048 17.3 0.0 0.35 11.6 0.0 2.4 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO34769.1 - 0.0078 16.8 0.1 2.9 8.6 0.0 2.6 2 1 1 3 3 3 2 Ankyrin repeats (many copies) Ank PF00023.30 ETO34769.1 - 0.09 13.3 0.0 1.1 9.8 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeat CAP_GLY PF01302.25 ETO34771.1 - 4.3e-14 52.3 1.5 9.8e-09 35.1 0.6 2.6 2 0 0 2 2 2 2 CAP-Gly domain S-AdoMet_synt_M PF02772.16 ETO34771.1 - 0.52 10.6 3.5 0.29 11.4 0.9 1.9 2 0 0 2 2 2 0 S-adenosylmethionine synthetase, central domain WD40 PF00400.32 ETO34772.1 - 8.7e-12 45.4 2.1 1.3e-07 32.2 0.8 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Serpin PF00079.20 ETO34773.1 - 3.6e-26 92.3 5.5 4.3e-26 92.1 5.5 1.0 1 0 0 1 1 1 1 Serpin (serine protease inhibitor) SLED PF12140.8 ETO34773.1 - 0.14 12.6 0.7 0.29 11.7 0.6 1.5 1 1 0 1 1 1 0 SLED domain Caps_synth_CapC PF14102.6 ETO34774.1 - 0.022 15.1 0.2 1.2 9.6 0.1 2.4 2 0 0 2 2 2 0 Capsule biosynthesis CapC PDZ_6 PF17820.1 ETO34774.1 - 0.035 14.0 0.0 0.082 12.8 0.0 1.6 1 0 0 1 1 1 0 PDZ domain PDZ_2 PF13180.6 ETO34774.1 - 0.059 13.7 0.5 0.21 11.9 0.0 2.2 2 0 0 2 2 2 0 PDZ domain PDZ PF00595.24 ETO34774.1 - 0.089 13.2 0.0 0.21 11.9 0.0 1.6 1 0 0 1 1 1 0 PDZ domain DUF3089 PF11288.8 ETO34775.1 - 6.8e-11 42.1 0.0 8.7e-11 41.7 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3089) DUF3089 PF11288.8 ETO34776.1 - 5.6e-18 65.2 0.1 9.7e-18 64.4 0.1 1.4 1 1 0 1 1 1 1 Protein of unknown function (DUF3089) DDHD PF02862.17 ETO34777.1 - 0.32 11.1 3.5 0.47 10.6 3.5 1.3 1 0 0 1 1 1 0 DDHD domain DUF3959 PF13105.6 ETO34777.1 - 0.54 9.7 1.7 0.84 9.1 1.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) DUF1387 PF07139.11 ETO34780.1 - 0.88 9.2 20.8 1 9.1 20.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) DUF4614 PF15391.6 ETO34780.1 - 7.7 6.5 10.5 5 7.1 9.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4614) Hep_59 PF07052.11 ETO34783.1 - 0.39 11.5 5.4 3.5 8.4 2.5 2.9 3 0 0 3 3 3 0 Hepatocellular carcinoma-associated antigen 59 FAF PF11250.8 ETO34784.1 - 1.5 9.1 5.1 9 6.6 0.6 2.7 2 0 0 2 2 2 0 Fantastic Four meristem regulator Tmemb_161AB PF10268.9 ETO34785.1 - 0.051 12.2 0.9 0.088 11.4 0.9 1.3 1 0 0 1 1 1 0 Predicted transmembrane protein 161AB YlqD PF11068.8 ETO34786.1 - 0.003 17.9 7.4 0.0047 17.3 7.4 1.3 1 0 0 1 1 1 1 YlqD protein FapA PF03961.13 ETO34786.1 - 0.0093 14.6 5.4 0.011 14.4 5.4 1.2 1 0 0 1 1 1 1 Flagellar Assembly Protein A APG6_N PF17675.1 ETO34786.1 - 0.012 16.2 7.2 0.02 15.4 7.2 1.3 1 0 0 1 1 1 0 Apg6 coiled-coil region FMO-like PF00743.19 ETO34786.1 - 0.017 13.5 0.0 0.026 13.0 0.0 1.3 1 0 0 1 1 1 0 Flavin-binding monooxygenase-like Snf7 PF03357.21 ETO34786.1 - 0.026 14.1 7.4 0.04 13.5 7.4 1.3 1 0 0 1 1 1 0 Snf7 V-set_CD47 PF08204.11 ETO34786.1 - 0.038 14.0 2.3 0.26 11.3 2.3 2.1 1 1 0 1 1 1 0 CD47 immunoglobulin-like domain IPK PF03770.16 ETO34786.1 - 0.69 9.7 8.8 0.65 9.8 2.0 2.1 1 1 1 2 2 2 0 Inositol polyphosphate kinase PriA_C PF18074.1 ETO34786.1 - 0.97 10.3 3.2 0.64 10.9 0.6 2.0 2 1 1 3 3 3 0 Primosomal protein N C-terminal domain CemA PF03040.14 ETO34786.1 - 2.5 8.0 7.3 19 5.1 4.7 2.2 1 1 1 2 2 2 0 CemA family Spc24 PF08286.11 ETO34786.1 - 3.3 8.0 8.9 9 6.6 8.9 1.8 1 1 0 1 1 1 0 Spc24 subunit of Ndc80 cNMP_binding PF00027.29 ETO34788.1 - 1e-34 118.4 0.1 1.8e-18 66.4 0.1 2.6 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Pkinase PF00069.25 ETO34788.1 - 1.9e-29 102.8 0.0 5.5e-29 101.3 0.0 1.8 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34788.1 - 8.7e-08 31.8 0.0 1.7e-07 30.8 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Cupin_2 PF07883.11 ETO34788.1 - 0.32 10.8 0.9 1.1 9.1 0.2 2.0 2 0 0 2 2 2 0 Cupin domain Senescence_reg PF04520.13 ETO34788.1 - 2.5 8.9 11.9 1.8 9.4 4.6 2.8 2 0 0 2 2 2 0 Senescence regulator CPSF100_C PF13299.6 ETO34788.1 - 6.7 6.9 9.7 17 5.5 0.6 2.8 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal Pkinase PF00069.25 ETO34789.1 - 1e-20 74.3 0.0 1.2e-20 74.0 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34789.1 - 3e-06 26.7 0.0 3.9e-06 26.4 0.0 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO34789.1 - 0.0019 17.6 0.0 0.0024 17.3 0.0 1.1 1 0 0 1 1 1 1 Kinase-like Kelch_6 PF13964.6 ETO34790.1 - 2.9e-05 24.2 5.0 1.5 9.2 0.2 4.6 4 1 1 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO34790.1 - 0.00022 21.1 5.0 0.02 14.9 0.3 4.5 4 1 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO34790.1 - 0.0015 18.1 0.3 0.0015 18.1 0.3 3.7 5 1 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO34790.1 - 0.0094 15.9 0.0 0.057 13.4 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO34790.1 - 0.0097 16.2 0.0 0.39 11.1 0.0 3.6 6 0 0 6 6 6 1 Galactose oxidase, central domain WD40 PF00400.32 ETO34791.1 - 9e-51 168.8 7.1 1.8e-09 38.0 0.4 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34791.1 - 4.6e-14 52.5 0.0 0.018 15.3 0.0 5.9 2 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34791.1 - 2.3e-09 36.7 0.9 0.13 11.2 0.0 5.7 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34791.1 - 1e-05 25.1 0.6 0.18 11.1 0.1 3.0 2 1 1 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO34791.1 - 2.4e-05 24.1 3.6 11 6.1 0.0 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO34791.1 - 6.8e-05 22.3 0.2 0.32 10.3 0.0 3.1 2 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Nup160 PF11715.8 ETO34791.1 - 0.00019 20.3 0.4 9.7 4.7 0.0 4.4 1 1 3 5 5 5 1 Nucleoporin Nup120/160 DUF2431 PF10354.9 ETO34791.1 - 0.017 15.4 0.0 6.9 6.9 0.0 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2431) Cytochrom_D1 PF02239.16 ETO34791.1 - 0.017 13.7 0.1 7 5.1 0.0 2.9 3 0 0 3 3 3 0 Cytochrome D1 heme domain BBS2_Mid PF14783.6 ETO34791.1 - 0.051 13.6 1.1 27 4.8 0.1 3.8 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, middle region MID_MedPIWI PF18296.1 ETO34792.1 - 0.19 11.5 13.0 1.5 8.5 5.6 2.2 2 0 0 2 2 2 0 MID domain of medPIWI RNA_pol_Rpc4 PF05132.14 ETO34792.1 - 5.2 7.5 9.6 2 8.9 3.1 2.3 2 0 0 2 2 2 0 RNA polymerase III RPC4 RP-C_C PF11800.8 ETO34792.1 - 6.3 6.8 10.1 0.66 10.0 4.1 2.0 2 0 0 2 2 2 0 Replication protein C C-terminal region CLN3 PF02487.17 ETO34792.1 - 6.3 5.7 7.8 1.7 7.6 2.7 2.2 3 0 0 3 3 3 0 CLN3 protein DUF61 PF01886.16 ETO34793.1 - 0.046 13.8 0.6 0.33 11.0 0.2 2.3 2 1 0 2 2 2 0 Protein of unknown function DUF61 Sirohm_synth_M PF14824.6 ETO34794.1 - 0.068 12.6 0.0 0.21 11.1 0.0 1.8 1 0 0 1 1 1 0 Sirohaem biosynthesis protein central FAM216B PF15107.6 ETO34794.1 - 0.096 12.6 0.2 1.1 9.2 0.0 2.2 2 0 0 2 2 2 0 FAM216B protein family Hid1 PF12722.7 ETO34794.1 - 0.39 8.8 7.0 0.45 8.6 7.0 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Presenilin PF01080.17 ETO34794.1 - 3.6 6.3 5.5 4.2 6.0 5.5 1.2 1 0 0 1 1 1 0 Presenilin Ribophorin_II PF05817.14 ETO34796.1 - 1.6e-06 27.0 1.0 1.6e-06 27.0 1.0 1.6 2 0 0 2 2 2 1 Oligosaccharyltransferase subunit Ribophorin II ESP PF16590.5 ETO34796.1 - 0.00068 19.8 0.3 0.0021 18.3 0.3 1.8 1 0 0 1 1 1 1 Exocrine gland-secreting peptide Kelch_6 PF13964.6 ETO34797.1 - 1e-06 28.8 2.6 0.46 10.8 0.1 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO34797.1 - 2.8e-06 27.1 4.0 0.013 15.4 0.2 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO34797.1 - 8.2e-06 25.3 1.9 0.016 14.8 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO34797.1 - 0.00056 19.9 0.2 0.014 15.4 0.0 3.4 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO34797.1 - 0.0016 18.4 7.2 0.95 9.5 0.2 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO34797.1 - 0.0019 18.4 0.2 0.034 14.5 0.0 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain DUF4509 PF14970.6 ETO34799.1 - 0.11 12.4 0.0 0.13 12.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4509) PI3K_C2 PF00792.24 ETO34801.1 - 2e-06 27.8 0.1 0.0033 17.3 0.1 2.9 2 0 0 2 2 2 2 Phosphoinositide 3-kinase C2 DUF4121 PF13497.6 ETO34801.1 - 0.0035 16.6 2.6 0.22 10.7 0.2 2.3 2 0 0 2 2 2 2 Domain of unknown function (DUF4121) IL4Ra_N PF09238.10 ETO34801.1 - 0.019 15.3 0.1 0.055 13.8 0.1 1.9 1 0 0 1 1 1 0 Interleukin-4 receptor alpha chain, N-terminal PI3K_rbd PF00794.18 ETO34801.1 - 0.041 14.1 0.0 0.14 12.3 0.0 1.9 1 0 0 1 1 1 0 PI3-kinase family, ras-binding domain RasGEF PF00617.19 ETO34802.1 - 1.2e-22 80.9 1.8 1.2e-22 80.9 1.8 1.7 2 1 0 2 2 2 1 RasGEF domain WD40 PF00400.32 ETO34803.1 - 9.8e-55 181.3 19.4 1.6e-09 38.2 0.0 8.5 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34803.1 - 2.1e-19 69.6 1.1 0.0078 16.5 0.1 6.9 1 1 8 9 9 9 5 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO34803.1 - 3.1e-14 52.5 8.4 0.045 13.7 0.0 6.9 7 0 0 7 7 7 5 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO34803.1 - 3.8e-11 42.5 1.4 0.046 12.7 0.2 5.4 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO34803.1 - 1.1e-06 27.6 5.1 0.47 9.0 0.1 5.4 2 2 2 5 5 5 2 Nucleoporin Nup120/160 Coatomer_WDAD PF04053.14 ETO34803.1 - 3.6e-05 23.0 0.1 0.00034 19.8 0.0 2.1 1 1 1 2 2 2 1 Coatomer WD associated region WD40_like PF17005.5 ETO34803.1 - 4e-05 23.1 4.2 1.4 8.2 0.1 4.4 2 2 3 5 5 5 2 WD40-like domain Nbas_N PF15492.6 ETO34803.1 - 4.2e-05 23.0 3.0 0.84 8.9 0.0 4.3 2 1 3 5 5 5 2 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO34803.1 - 0.0027 17.3 0.0 0.043 13.4 0.0 2.6 1 1 2 3 3 3 1 PQQ-like domain DPPIV_N PF00930.21 ETO34803.1 - 0.0067 15.2 0.0 25 3.5 0.0 4.7 2 1 2 5 5 5 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Str_synth PF03088.16 ETO34803.1 - 0.0094 16.1 0.0 11 6.2 0.0 3.6 3 1 0 3 3 3 1 Strictosidine synthase DUF4265 PF14085.6 ETO34803.1 - 0.012 15.6 0.2 6.8 6.7 0.0 3.6 4 1 1 5 5 5 0 Domain of unknown function (DUF4265) Mid2 PF04478.12 ETO34803.1 - 0.013 15.4 0.4 8.3 6.2 0.0 2.9 2 2 0 2 2 2 0 Mid2 like cell wall stress sensor Cauli_AT PF03233.13 ETO34804.1 - 0.41 10.6 5.3 0.58 10.1 5.3 1.2 1 0 0 1 1 1 0 Aphid transmission protein Pet127 PF08634.10 ETO34805.1 - 0.067 12.6 0.0 0.079 12.4 0.0 1.1 1 0 0 1 1 1 0 Mitochondrial protein Pet127 Pkinase PF00069.25 ETO34807.1 - 5.5e-30 104.6 4.5 3.7e-15 56.0 0.1 2.3 1 1 1 2 2 2 2 Protein kinase domain cNMP_binding PF00027.29 ETO34807.1 - 1.3e-18 66.8 0.4 5.3e-18 64.9 0.0 2.1 2 0 0 2 2 2 1 Cyclic nucleotide-binding domain Pkinase_Tyr PF07714.17 ETO34807.1 - 1.1e-11 44.6 1.3 3.3e-07 29.8 0.0 2.3 1 1 1 2 2 2 2 Protein tyrosine kinase cNMP_binding PF00027.29 ETO34808.1 - 8.3e-41 138.0 0.3 7.5e-24 83.6 0.1 2.4 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain Cupin_2 PF07883.11 ETO34808.1 - 0.0029 17.3 0.4 0.019 14.7 0.0 2.2 2 0 0 2 2 2 1 Cupin domain Cupin_3 PF05899.12 ETO34808.1 - 0.22 11.2 0.6 1 9.1 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF861) WD40 PF00400.32 ETO34809.1 - 4.9e-14 52.5 0.8 2.1e-08 34.7 0.0 3.6 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34809.1 - 6.7e-05 23.1 0.3 0.049 13.9 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34809.1 - 0.00037 19.3 1.7 0.077 11.6 0.0 2.5 1 1 1 2 2 2 2 Nucleoporin Nup120/160 PQQ_2 PF13360.6 ETO34809.1 - 0.017 14.7 0.0 0.024 14.2 0.0 1.2 1 0 0 1 1 1 0 PQQ-like domain SIS PF01380.22 ETO34810.1 - 0.04 13.8 1.5 0.067 13.0 0.4 1.8 2 0 0 2 2 2 0 SIS domain DUF5525 PF17663.1 ETO34810.1 - 0.58 8.2 5.8 0.82 7.7 5.8 1.2 1 0 0 1 1 1 0 Family of unknown function (DUF5525) CLASP_N PF12348.8 ETO34811.1 - 0.13 11.8 5.3 1.2 8.7 0.2 3.3 3 0 0 3 3 3 0 CLASP N terminal Vac14_Fab1_bd PF12755.7 ETO34811.1 - 0.33 11.6 0.0 0.33 11.6 0.0 3.3 4 0 0 4 4 4 0 Vacuolar 14 Fab1-binding region Aa_trans PF01490.18 ETO34813.1 - 8.5e-48 163.0 20.0 6.2e-47 160.2 20.0 1.9 1 1 0 1 1 1 1 Transmembrane amino acid transporter protein DUF3593 PF12159.8 ETO34813.1 - 0.048 13.7 0.4 0.048 13.7 0.4 2.9 2 1 1 3 3 3 0 Protein of unknown function (DUF3593) MORN PF02493.20 ETO34814.1 - 8e-26 88.4 27.2 7.8e-09 34.9 1.6 6.7 7 0 0 7 7 7 5 MORN repeat DpaA_N PF16924.5 ETO34815.1 - 0.045 13.8 0.4 0.064 13.3 0.4 1.4 1 0 0 1 1 1 0 Dipicolinate synthase subunit A N-terminal domain DUF1168 PF06658.12 ETO34815.1 - 0.41 10.5 11.3 0.57 10.0 11.3 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1168) Peptidase_S49_N PF08496.10 ETO34815.1 - 3.9 7.5 9.4 0.23 11.5 3.0 1.9 2 0 0 2 2 2 0 Peptidase family S49 N-terminal RTC PF01137.21 ETO34817.1 - 5.2e-29 101.0 0.0 6.6e-29 100.7 0.0 1.1 1 0 0 1 1 1 1 RNA 3'-terminal phosphate cyclase AdoMetDC_leader PF08132.11 ETO34817.1 - 0.00031 20.6 0.0 0.00059 19.7 0.0 1.4 1 0 0 1 1 1 1 S-adenosyl-l-methionine decarboxylase leader peptide FXMRP1_C_core PF12235.8 ETO34817.1 - 0.0041 17.8 1.8 0.0053 17.4 1.8 1.3 1 0 0 1 1 1 1 Fragile X-related 1 protein core C terminal Complex1_LYR PF05347.15 ETO34818.1 - 1.7e-09 37.6 5.2 3.8e-09 36.4 5.2 1.7 1 0 0 1 1 1 1 Complex 1 protein (LYR family) Complex1_LYR_2 PF13233.6 ETO34818.1 - 0.00034 21.3 3.2 0.00078 20.1 3.2 1.6 1 0 0 1 1 1 1 Complex1_LYR-like DUF1891 PF09004.10 ETO34818.1 - 0.00063 19.3 0.1 0.0013 18.3 0.1 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF1891) Complex1_LYR_1 PF13232.6 ETO34818.1 - 0.021 15.4 0.3 0.041 14.5 0.3 1.5 1 0 0 1 1 1 0 Complex1_LYR-like Pkinase PF00069.25 ETO34819.1 - 5.9e-42 143.9 2.8 1.7e-41 142.3 0.1 2.5 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34819.1 - 3.2e-14 52.8 0.0 6.4e-14 51.9 0.0 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO34819.1 - 4.7e-05 22.3 1.3 0.00013 20.8 0.9 1.9 1 1 0 1 1 1 1 Fungal protein kinase FTA2 PF13095.6 ETO34819.1 - 0.00014 21.5 1.0 0.42 10.2 0.1 2.6 2 1 0 2 2 2 2 Kinetochore Sim4 complex subunit FTA2 APH PF01636.23 ETO34819.1 - 0.00077 19.5 0.0 0.41 10.5 0.0 2.2 2 0 0 2 2 2 2 Phosphotransferase enzyme family Kdo PF06293.14 ETO34819.1 - 0.0013 18.1 0.2 0.0026 17.2 0.2 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family G-alpha PF00503.20 ETO34819.1 - 0.0072 15.5 1.3 0.0099 15.1 1.3 1.2 1 0 0 1 1 1 1 G-protein alpha subunit RNA_pol_Rpb5_C PF01191.19 ETO34819.1 - 0.03 14.2 0.2 0.081 12.8 0.2 1.7 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain Ago_N_1 PF18351.1 ETO34819.1 - 0.67 10.4 3.8 2.9 8.4 0.2 3.0 2 1 1 3 3 3 0 Fungal Argonaute N-terminal domain XhlA PF10779.9 ETO34820.1 - 0.11 12.7 4.1 13 6.0 3.3 2.3 2 0 0 2 2 2 0 Haemolysin XhlA MitMem_reg PF13012.6 ETO34821.1 - 0.18 12.2 1.9 0.85 10.1 0.3 2.5 2 1 0 2 2 2 0 Maintenance of mitochondrial structure and function NBP1 PF08537.10 ETO34821.1 - 0.26 10.7 5.1 0.059 12.8 1.6 1.6 2 0 0 2 2 2 0 Fungal Nap binding protein NBP1 MetOD2 PF18548.1 ETO34821.1 - 6.9 6.9 7.3 5.8 7.1 0.3 3.6 4 0 0 4 4 4 0 Metanogen output domain 2 Voltage_CLC PF00654.20 ETO34822.1 - 1.6e-32 113.1 9.1 1.9e-32 112.9 9.1 1.0 1 0 0 1 1 1 1 Voltage gated chloride channel Gly-zipper_Omp PF13488.6 ETO34822.1 - 0.05 13.6 2.7 0.05 13.6 2.7 2.0 2 0 0 2 2 2 0 Glycine zipper Gly-zipper_YMGG PF13441.6 ETO34822.1 - 1.4 8.8 7.6 0.63 9.8 5.0 1.7 2 0 0 2 2 2 0 YMGG-like Gly-zipper Romo1 PF10247.9 ETO34822.1 - 1.5 9.3 6.8 4.4 7.7 1.2 3.1 3 0 0 3 3 3 0 Reactive mitochondrial oxygen species modulator 1 DUF3037 PF11236.8 ETO34823.1 - 0.054 13.9 0.0 0.11 13.0 0.0 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3037) MIP-T3 PF10243.9 ETO34824.1 - 3.2e-31 107.6 0.1 6.1e-31 106.7 0.1 1.4 1 0 0 1 1 1 1 Microtubule-binding protein MIP-T3 CH-like domain Vfa1 PF08432.10 ETO34824.1 - 0.0043 17.4 6.2 0.0067 16.8 6.2 1.3 1 0 0 1 1 1 1 AAA-ATPase Vps4-associated protein 1 Inovirus_Gp2 PF11726.8 ETO34824.1 - 0.067 13.1 0.2 0.11 12.4 0.2 1.4 1 0 0 1 1 1 0 Inovirus Gp2 CLN3 PF02487.17 ETO34824.1 - 0.25 10.4 0.8 0.31 10.0 0.8 1.2 1 0 0 1 1 1 0 CLN3 protein DUF3899 PF13038.6 ETO34824.1 - 1.1 9.8 5.4 5.8 7.5 5.2 2.3 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) MIP-T3_C PF17749.1 ETO34825.1 - 2.7e-17 63.2 14.6 3e-17 63.0 14.1 1.3 1 1 0 1 1 1 1 Microtubule-binding protein MIP-T3 C-terminal region LAGLIDADG_WhiA PF14527.6 ETO34825.1 - 0.44 10.7 4.0 0.27 11.4 1.7 1.9 2 0 0 2 2 2 0 WhiA LAGLIDADG-like domain eIF-4B PF06273.11 ETO34825.1 - 1.3 8.0 5.1 2.4 7.1 5.1 1.3 1 0 0 1 1 1 0 Plant specific eukaryotic initiation factor 4B TPR_12 PF13424.6 ETO34827.1 - 3.6e-18 65.6 0.4 6.6e-10 39.1 0.1 2.5 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO34827.1 - 5e-10 38.7 1.1 0.0022 17.9 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO34827.1 - 3.1e-09 36.4 0.1 0.00021 21.0 0.0 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO34827.1 - 4.1e-09 35.9 10.2 1.7e-06 27.6 2.8 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO34827.1 - 5.9e-09 35.4 8.0 1.8e-05 24.5 1.3 3.6 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO34827.1 - 2.1e-08 33.8 10.5 6.6e-05 22.8 2.0 3.9 3 0 0 3 3 3 3 Tetratricopeptide repeat MIT PF04212.18 ETO34827.1 - 0.014 15.4 0.4 0.062 13.4 0.4 2.1 1 0 0 1 1 1 0 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO34827.1 - 0.03 15.1 0.1 1 10.3 0.0 3.0 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO34827.1 - 0.058 14.1 2.8 1.6 9.5 0.4 3.5 3 0 0 3 3 3 0 Tetratricopeptide repeat ParG PF09274.10 ETO34827.1 - 0.072 13.2 0.1 0.17 12.0 0.1 1.6 1 0 0 1 1 1 0 ParG TPR_11 PF13414.6 ETO34827.1 - 0.079 12.7 4.4 6 6.6 2.0 3.7 3 0 0 3 3 3 0 TPR repeat Fis1_TPR_C PF14853.6 ETO34827.1 - 0.66 10.1 2.7 2.4 8.3 0.1 2.8 3 0 0 3 3 3 0 Fis1 C-terminal tetratricopeptide repeat Pkinase PF00069.25 ETO34828.1 - 1.4e-36 126.3 0.4 1.8e-36 125.8 0.4 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO34828.1 - 6.8e-24 84.5 0.1 9e-24 84.2 0.1 1.1 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO34828.1 - 0.0003 20.2 0.1 0.00048 19.5 0.1 1.4 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO34828.1 - 0.00046 20.2 1.7 0.0012 18.8 1.5 1.4 1 1 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO34828.1 - 0.016 14.8 0.3 0.024 14.3 0.3 1.3 1 0 0 1 1 1 0 RIO1 family YrbL-PhoP_reg PF10707.9 ETO34828.1 - 0.037 13.5 0.1 0.07 12.7 0.1 1.4 1 0 0 1 1 1 0 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 ETO34828.1 - 0.063 12.9 0.4 0.093 12.3 0.4 1.3 1 0 0 1 1 1 0 Choline/ethanolamine kinase Kelch_1 PF01344.25 ETO34829.1 - 4.9e-06 26.0 1.4 0.00027 20.5 0.8 3.5 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO34829.1 - 7.1e-06 25.8 1.8 0.03 14.3 0.1 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO34829.1 - 2.9e-05 24.2 1.3 7.8 6.9 0.2 4.6 3 1 1 4 4 4 3 Kelch motif Kelch_3 PF13415.6 ETO34829.1 - 0.003 17.8 0.5 0.042 14.1 0.0 3.2 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO34829.1 - 0.0033 17.4 0.0 0.026 14.5 0.0 2.5 2 0 0 2 2 2 1 Galactose oxidase, central domain DUF4084 PF13321.6 ETO34829.1 - 0.0076 15.8 1.3 0.012 15.2 1.3 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4084) Kelch_5 PF13854.6 ETO34829.1 - 0.073 13.1 6.7 5.5 7.1 1.0 4.3 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO34830.1 - 1.5e-23 82.6 19.8 0.0001 23.0 1.3 7.5 8 0 0 8 8 8 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO34830.1 - 5.8e-07 28.5 5.3 0.092 11.4 0.0 4.4 2 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34830.1 - 6.2e-07 29.6 4.7 1.1 9.6 0.0 5.7 5 2 2 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain DUF5570 PF17731.1 ETO34830.1 - 0.072 13.2 0.7 9 6.4 0.1 2.7 3 0 0 3 3 3 0 Family of unknown function (DUF5570) WD40 PF00400.32 ETO34832.1 - 9.3e-18 64.3 10.8 1.8e-05 25.4 0.0 4.5 4 2 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34832.1 - 2.1e-05 24.7 0.6 0.36 11.2 0.1 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34832.1 - 2.7e-05 23.0 1.3 0.19 10.3 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34832.1 - 0.00036 20.0 1.9 0.047 13.0 0.3 2.8 1 1 2 3 3 3 2 WD40-like domain LydB PF16084.5 ETO34832.1 - 0.093 12.5 0.4 0.42 10.4 0.1 1.9 1 1 1 2 2 2 0 LydA-holin antagonist DUF1581 PF07619.11 ETO34833.1 - 0.016 15.4 0.0 0.03 14.5 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1581) RNA_pol_Rpb5_C PF01191.19 ETO34835.1 - 0.026 14.4 0.0 0.066 13.1 0.0 1.6 1 0 0 1 1 1 0 RNA polymerase Rpb5, C-terminal domain WD40 PF00400.32 ETO34837.1 - 1.3e-05 25.9 0.7 0.00012 22.8 0.0 2.6 3 0 0 3 3 3 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO34837.1 - 0.045 12.4 0.2 0.17 10.5 0.1 1.7 1 1 1 2 2 2 0 Nucleoporin Nup120/160 CNDH2_C PF16858.5 ETO34839.1 - 0.021 14.7 0.2 0.23 11.3 0.1 2.0 2 0 0 2 2 2 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Lipocalin PF00061.23 ETO34839.1 - 0.11 12.7 0.0 0.25 11.6 0.0 1.5 2 0 0 2 2 2 0 Lipocalin / cytosolic fatty-acid binding protein family UCH PF00443.29 ETO34840.1 - 9.2e-26 90.9 0.0 9.6e-26 90.8 0.0 1.0 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO34840.1 - 0.0023 17.6 0.0 0.0024 17.5 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase PPR_2 PF13041.6 ETO34841.1 - 3.3e-09 36.8 0.2 8.8e-06 25.8 0.1 2.6 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETO34841.1 - 3.9e-05 23.6 1.1 0.0013 18.9 0.1 3.3 3 0 0 3 3 3 1 PPR repeat PPR_1 PF12854.7 ETO34841.1 - 0.00056 19.5 0.0 0.0016 18.1 0.0 1.7 1 0 0 1 1 1 1 PPR repeat ATP13 PF12921.7 ETO34841.1 - 0.006 16.4 0.5 0.067 13.0 0.0 2.9 2 1 0 2 2 2 1 Mitochondrial ATPase expression Ras PF00071.22 ETO34843.1 - 1e-35 122.7 0.6 2.4e-25 89.0 0.4 2.2 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO34843.1 - 1.6e-30 105.8 2.1 6e-20 71.7 1.5 2.3 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO34843.1 - 7.1e-13 48.4 0.2 1.6e-09 37.4 0.3 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO34843.1 - 0.00032 20.1 0.2 0.0006 19.2 0.2 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Peptidase_U57 PF05582.12 ETO34843.1 - 0.004 16.5 3.2 0.004 16.5 3.2 1.4 1 1 1 2 2 2 1 YabG peptidase U57 Terminase_6 PF03237.15 ETO34843.1 - 0.018 14.7 0.0 0.044 13.4 0.0 1.6 2 0 0 2 2 2 0 Terminase-like family Dynamin_N PF00350.23 ETO34843.1 - 0.026 14.6 2.6 0.12 12.5 2.6 2.1 1 1 0 1 1 1 0 Dynamin family FAM60A PF15396.6 ETO34843.1 - 0.082 12.9 7.9 0.12 12.4 7.9 1.2 1 0 0 1 1 1 0 Protein Family FAM60A Apis_Csd PF11671.8 ETO34843.1 - 0.17 11.9 8.6 0.3 11.1 8.6 1.5 1 0 0 1 1 1 0 Complementary sex determiner protein MCM_bind PF09739.9 ETO34843.1 - 0.25 9.7 8.8 0.29 9.5 8.8 1.1 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor NPR3 PF03666.13 ETO34843.1 - 0.29 9.9 9.8 0.32 9.7 9.8 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 HECT PF00632.25 ETO34844.1 - 6.6e-94 314.8 0.9 9.5e-94 314.3 0.9 1.2 1 0 0 1 1 1 1 HECT-domain (ubiquitin-transferase) TIR_3 PF18567.1 ETO34845.1 - 0.014 15.4 0.7 0.022 14.8 0.7 1.4 1 0 0 1 1 1 0 Toll/interleukin-1 receptor domain YMF19 PF02326.15 ETO34845.1 - 1.1 10.0 9.9 9.3 7.1 9.9 2.2 1 1 0 1 1 1 0 Plant ATP synthase F0 PEPcase_2 PF14010.6 ETO34846.1 - 0.029 12.9 0.5 0.033 12.7 0.5 1.1 1 0 0 1 1 1 0 Phosphoenolpyruvate carboxylase Clusterin PF01093.17 ETO34846.1 - 0.16 11.0 0.1 0.21 10.6 0.1 1.1 1 0 0 1 1 1 0 Clusterin Peptidase_M20 PF01546.28 ETO34847.1 - 1e-05 25.3 0.0 1.4e-05 24.9 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M20/M25/M40 Peptidase_M28 PF04389.17 ETO34847.1 - 0.0041 16.8 0.1 0.0072 16.0 0.1 1.4 1 0 0 1 1 1 1 Peptidase family M28 M20_dimer PF07687.14 ETO34847.1 - 0.041 13.8 0.0 0.082 12.8 0.0 1.4 1 0 0 1 1 1 0 Peptidase dimerisation domain Presenilin PF01080.17 ETO34848.1 - 0.14 10.9 5.3 0.2 10.4 5.3 1.3 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO34848.1 - 0.27 10.0 8.3 0.35 9.6 8.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Zip PF02535.22 ETO34848.1 - 1.2 8.2 5.8 1.5 7.9 5.8 1.3 1 0 0 1 1 1 0 ZIP Zinc transporter Folate_carrier PF01770.18 ETO34848.1 - 2.6 6.7 3.6 3.7 6.2 3.6 1.3 1 0 0 1 1 1 0 Reduced folate carrier CSRNP_N PF16019.5 ETO34849.1 - 8.7 6.2 10.2 1.1 9.2 1.0 2.3 2 0 0 2 2 2 0 Cysteine/serine-rich nuclear protein N-terminus RVT_1 PF00078.27 ETO34850.1 - 1.9e-12 47.2 0.2 1.2e-11 44.6 0.2 2.0 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DSPc PF00782.20 ETO34851.1 - 2e-13 50.3 0.0 2.5e-13 50.0 0.0 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO34851.1 - 1.3e-05 24.9 0.1 2.7e-05 23.8 0.0 1.5 1 1 1 2 2 2 1 Protein-tyrosine phosphatase PTPlike_phytase PF14566.6 ETO34851.1 - 0.00024 21.2 0.0 0.00032 20.9 0.0 1.1 1 0 0 1 1 1 1 Inositol hexakisphosphate Y_phosphatase3 PF13350.6 ETO34851.1 - 0.053 13.5 0.1 0.064 13.2 0.1 1.1 1 0 0 1 1 1 0 Tyrosine phosphatase family Y_phosphatase2 PF03162.13 ETO34851.1 - 0.055 13.0 0.1 0.079 12.5 0.1 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family DUF442 PF04273.13 ETO34851.1 - 0.096 12.8 0.0 0.16 12.1 0.0 1.3 1 0 0 1 1 1 0 Putative phosphatase (DUF442) Ank_2 PF12796.7 ETO34853.1 - 8.5e-11 42.3 0.0 1.7e-10 41.4 0.0 1.5 1 0 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO34853.1 - 1.2e-10 40.7 0.1 4.3e-05 23.6 0.0 2.9 3 0 0 3 3 3 2 Ankyrin repeat Ank_4 PF13637.6 ETO34853.1 - 2.8e-09 37.3 1.9 5.8e-05 23.6 0.1 3.3 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO34853.1 - 3.3e-09 36.8 0.0 0.00022 21.5 0.0 2.6 2 0 0 2 2 2 2 Ankyrin repeat Ank_5 PF13857.6 ETO34853.1 - 4.3e-07 30.1 0.2 0.0029 17.9 0.0 2.6 1 1 1 2 2 2 2 Ankyrin repeats (many copies) U3snoRNP10 PF12397.8 ETO34853.1 - 0.15 12.4 0.4 0.28 11.5 0.4 1.4 1 0 0 1 1 1 0 U3 small nucleolar RNA-associated protein 10 WD40 PF00400.32 ETO34854.1 - 8e-52 172.1 6.7 4.3e-09 36.8 0.0 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34854.1 - 6.6e-20 71.2 1.7 0.00073 19.8 0.0 6.6 1 1 6 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34854.1 - 9.6e-15 54.4 1.6 0.02 13.9 0.0 6.4 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO34854.1 - 0.0001 22.1 2.5 7.6 6.6 0.0 5.5 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ETO34854.1 - 0.004 17.0 0.0 0.087 12.6 0.0 2.4 2 1 0 2 2 2 1 Lipoprotein LpqB beta-propeller domain Nup160 PF11715.8 ETO34854.1 - 0.0098 14.6 8.2 1.9 7.0 0.2 5.1 1 1 4 6 6 6 1 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO34854.1 - 0.013 14.1 0.1 11 4.4 0.0 3.1 2 1 2 4 4 4 0 Cytochrome D1 heme domain Mid2 PF04478.12 ETO34854.1 - 0.033 14.0 7.5 0.14 11.9 4.7 2.9 3 1 0 3 3 3 0 Mid2 like cell wall stress sensor VID27 PF08553.10 ETO34854.1 - 0.047 12.8 0.2 1.1 8.3 0.0 2.4 2 1 0 2 2 2 0 VID27 C-terminal WD40-like domain Chordopox_A13L PF05961.11 ETO34854.1 - 0.2 11.9 4.3 0.43 10.9 3.3 1.9 2 0 0 2 2 2 0 Chordopoxvirus A13L protein p450 PF00067.22 ETO34855.1 - 2.1e-08 33.4 0.5 2.4e-08 33.1 0.5 1.0 1 0 0 1 1 1 1 Cytochrome P450 RRM_1 PF00076.22 ETO34857.1 - 2.3e-09 36.9 0.0 3.6e-09 36.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO34858.1 - 8.9e-07 28.6 0.0 1.9e-06 27.6 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO34858.1 - 0.019 15.1 0.0 0.14 12.3 0.0 2.4 2 0 0 2 2 2 0 RNA recognition motif RNA_bind PF08675.11 ETO34858.1 - 0.11 12.6 0.0 0.29 11.2 0.0 1.7 1 0 0 1 1 1 0 RNA binding domain Ras PF00071.22 ETO34859.1 - 2.2e-28 98.9 0.0 3.3e-28 98.3 0.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO34859.1 - 5.2e-13 49.3 0.0 1.2e-12 48.1 0.0 1.6 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO34859.1 - 0.0013 18.2 0.0 0.13 11.7 0.0 2.2 2 0 0 2 2 2 2 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO34859.1 - 0.0029 17.5 0.0 1.3 8.9 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase ATPase_2 PF01637.18 ETO34859.1 - 0.0096 15.9 0.0 0.018 15.0 0.0 1.4 1 0 0 1 1 1 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO34859.1 - 0.016 15.6 0.0 0.035 14.5 0.0 1.5 2 0 0 2 2 2 0 AAA ATPase domain Septin PF00735.18 ETO34859.1 - 0.054 12.8 0.3 0.17 11.2 0.0 1.9 3 0 0 3 3 3 0 Septin WD40 PF00400.32 ETO34860.1 - 1.5e-62 206.0 17.8 2.9e-10 40.5 0.1 8.6 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34860.1 - 8.1e-16 58.1 2.6 0.031 14.6 0.0 6.6 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34860.1 - 2.5e-13 49.7 0.8 0.009 15.0 0.0 6.3 2 2 4 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_5 PF13854.6 ETO34860.1 - 1.2e-05 25.2 3.2 0.057 13.4 0.0 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO34860.1 - 1.9e-05 24.4 2.9 0.047 13.7 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO34860.1 - 2.2e-05 24.5 2.5 0.028 14.7 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO34860.1 - 0.00027 20.4 0.7 0.44 10.2 0.0 3.6 4 0 0 4 4 4 2 Kelch motif DUF4999 PF16390.5 ETO34860.1 - 0.002 18.4 5.3 1.6 9.0 0.2 5.0 5 0 0 5 5 5 1 Domain of unknown function Kelch_4 PF13418.6 ETO34860.1 - 0.004 17.1 0.0 0.74 9.9 0.0 3.1 2 0 0 2 2 2 1 Galactose oxidase, central domain DUF1258 PF06869.12 ETO34860.1 - 0.0059 16.1 0.3 2.2 7.7 0.0 2.5 2 0 0 2 2 2 2 Protein of unknown function (DUF1258) SdiA-regulated PF06977.11 ETO34860.1 - 0.067 12.4 0.0 0.35 10.1 0.0 2.1 2 0 0 2 2 2 0 SdiA-regulated Cytochrom_D1 PF02239.16 ETO34860.1 - 0.14 10.6 1.5 2.6 6.5 0.1 2.8 2 1 2 4 4 4 0 Cytochrome D1 heme domain WD40 PF00400.32 ETO34861.1 - 6.6e-43 143.9 28.6 4.6e-07 30.4 0.1 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34861.1 - 3.3e-16 59.4 1.5 0.03 14.6 0.1 5.8 5 1 0 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO34861.1 - 0.00017 22.2 2.1 0.00017 22.2 2.1 2.7 4 0 0 4 4 4 1 TRAF-type zinc finger KASH_CCD PF14662.6 ETO34861.1 - 0.14 12.0 23.3 0.28 11.0 23.3 1.4 1 0 0 1 1 1 0 Coiled-coil region of CCDC155 or KASH Spc24 PF08286.11 ETO34861.1 - 0.34 11.2 12.0 0.076 13.3 4.0 2.7 2 0 0 2 2 2 0 Spc24 subunit of Ndc80 IQ_SEC7_PH PF16453.5 ETO34864.1 - 0.01 15.8 0.1 0.021 14.8 0.1 1.6 1 0 0 1 1 1 0 PH domain Stealth_CR4 PF17103.5 ETO34865.1 - 0.027 14.4 0.5 0.2 11.6 0.0 2.4 2 0 0 2 2 2 0 Stealth protein CR4, conserved region 4 zf-CCCH PF00642.24 ETO34866.1 - 3.9e-08 33.0 17.8 3.2e-07 30.1 4.4 2.9 2 1 0 2 2 2 2 Zinc finger C-x8-C-x5-C-x3-H type (and similar) zf-CCCH_4 PF18044.1 ETO34866.1 - 7.9e-07 28.7 9.1 0.00027 20.6 2.9 2.4 2 0 0 2 2 2 2 CCCH-type zinc finger zf-CCCH_2 PF14608.6 ETO34866.1 - 1e-05 25.8 6.2 0.022 15.3 1.2 2.5 2 0 0 2 2 2 2 RNA-binding, Nab2-type zinc finger zf_CCCH_4 PF18345.1 ETO34866.1 - 1.6e-05 24.8 13.5 0.00095 19.1 5.7 2.5 2 0 0 2 2 2 2 Zinc finger domain Dapper PF15268.6 ETO34866.1 - 0.38 9.5 24.9 0.47 9.2 24.9 1.1 1 0 0 1 1 1 0 Dapper Raftlin PF15250.6 ETO34866.1 - 0.68 8.6 17.9 1 8.0 17.9 1.3 1 0 0 1 1 1 0 Raftlin Transformer PF06495.11 ETO34868.1 - 0.17 12.0 1.0 0.3 11.1 0.1 1.9 2 0 0 2 2 2 0 Fruit fly transformer protein AF-4 PF05110.13 ETO34868.1 - 0.4 8.7 26.9 0.28 9.2 8.6 3.0 3 0 0 3 3 3 0 AF-4 proto-oncoprotein WD40 PF00400.32 ETO34870.1 - 1.9e-103 335.5 45.2 6.6e-08 33.1 0.0 15.3 15 0 0 15 15 15 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34870.1 - 1.9e-29 101.8 20.6 0.015 15.6 0.0 12.0 1 1 13 14 14 14 12 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34870.1 - 4.5e-21 75.2 6.6 0.0013 17.8 0.0 10.4 2 2 6 10 10 10 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34870.1 - 1.4e-15 57.4 17.3 4.4e-06 26.2 0.0 7.5 6 2 1 7 7 7 4 WD40-like domain Nup160 PF11715.8 ETO34870.1 - 5.8e-14 51.6 28.4 0.76 8.3 0.1 12.5 2 2 9 12 12 12 6 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO34870.1 - 4.2e-08 32.7 2.0 8.5e-08 31.7 2.0 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Str_synth PF03088.16 ETO34870.1 - 0.00011 22.3 0.2 11 6.2 0.0 6.1 5 2 2 7 7 6 0 Strictosidine synthase Pentapeptide_4 PF13599.6 ETO34870.1 - 0.00013 22.1 0.1 0.0003 20.9 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO34870.1 - 0.00021 20.0 10.2 0.38 9.2 0.1 5.1 2 1 2 6 6 6 2 Cytochrome D1 heme domain Mid2 PF04478.12 ETO34870.1 - 0.0008 19.3 5.1 1.2 9.0 0.0 5.9 6 0 0 6 6 6 1 Mid2 like cell wall stress sensor DUF3475 PF11961.8 ETO34870.1 - 0.0017 18.4 2.6 0.88 9.7 0.1 5.1 6 0 0 6 6 6 1 Domain of unknown function (DUF3475) Malectin_like PF12819.7 ETO34870.1 - 0.0017 17.6 3.1 0.95 8.6 0.1 4.8 5 1 0 5 5 5 1 Malectin-like domain Pentapeptide_3 PF13576.6 ETO34870.1 - 0.0029 17.7 0.6 0.0029 17.7 0.6 2.2 2 0 0 2 2 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO34870.1 - 0.039 13.9 17.8 6.8 6.8 0.0 7.4 8 0 0 8 8 8 0 WD40-like Beta Propeller Repeat SoxZ PF08770.11 ETO34870.1 - 0.052 13.3 0.7 6.9 6.5 0.0 4.3 6 0 0 6 6 5 0 Sulphur oxidation protein SoxZ RE_XamI PF09572.10 ETO34870.1 - 0.12 12.0 0.0 5.1 6.7 0.0 3.5 4 0 0 4 4 4 0 XamI restriction endonuclease Proteasome_A_N PF10584.9 ETO34870.1 - 7.9 6.3 5.7 90 2.9 0.1 4.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Kelch_5 PF13854.6 ETO34871.1 - 0.018 15.0 2.3 1.5 8.9 0.0 3.0 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO34872.1 - 1.1e-50 168.5 16.3 3.1e-09 37.3 0.5 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34872.1 - 5.3e-24 84.3 1.5 1.2e-05 25.5 0.0 5.3 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34872.1 - 9.1e-15 54.4 0.6 0.068 12.1 0.0 5.9 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO34872.1 - 6.4e-14 52.3 0.4 1.6e-07 31.4 0.2 3.0 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO34872.1 - 1.9e-05 23.5 9.5 0.72 8.4 0.3 4.9 1 1 5 6 6 6 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34872.1 - 0.00034 20.1 0.6 0.48 9.7 0.1 2.5 2 1 0 2 2 2 2 WD40-like domain SGL PF08450.12 ETO34872.1 - 0.0024 17.5 0.1 0.019 14.5 0.0 2.3 1 1 1 2 2 2 1 SMP-30/Gluconolactonase/LRE-like region Nbas_N PF15492.6 ETO34872.1 - 0.0077 15.6 3.1 0.83 8.9 0.1 3.1 1 1 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO34872.1 - 0.009 15.9 4.3 18 5.4 0.0 4.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO34872.1 - 0.015 14.2 4.6 0.37 9.6 0.2 3.4 2 2 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Exo_endo_phos PF03372.23 ETO34875.1 - 0.0001 21.9 0.0 0.00016 21.2 0.0 1.4 1 0 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family Rsc14 PF08586.10 ETO34875.1 - 0.21 12.4 1.2 0.5 11.2 1.2 1.7 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit Renin_r PF07850.14 ETO34875.1 - 0.22 12.1 2.6 2.3 8.9 0.8 2.5 2 1 0 2 2 2 0 Renin receptor-like protein Trypan_PARP PF05887.11 ETO34875.1 - 6.7 6.7 7.2 11 6.0 7.2 1.2 1 0 0 1 1 1 0 Procyclic acidic repetitive protein (PARP) C2 PF00168.30 ETO34876.1 - 4.6e-07 30.1 0.0 8e-07 29.3 0.0 1.4 1 0 0 1 1 1 1 C2 domain CENP-B_dimeris PF09026.10 ETO34876.1 - 0.027 14.9 1.5 0.027 14.9 1.5 1.7 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Hid1 PF12722.7 ETO34876.1 - 0.086 11.0 7.4 0.11 10.6 7.4 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein EVI2A PF05399.11 ETO34876.1 - 0.55 9.8 9.2 0.89 9.1 9.2 1.4 1 0 0 1 1 1 0 Ectropic viral integration site 2A protein (EVI2A) Ndc1_Nup PF09531.10 ETO34876.1 - 1.5 7.4 6.6 1.7 7.2 6.6 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Presenilin PF01080.17 ETO34876.1 - 3.9 6.2 9.6 5.4 5.7 9.6 1.3 1 0 0 1 1 1 0 Presenilin Pap_E4 PF02711.14 ETO34876.1 - 5.9 7.9 11.7 19 6.3 4.3 2.4 2 0 0 2 2 2 0 E4 protein WD40 PF00400.32 ETO34877.1 - 6.5e-130 419.2 51.9 3.8e-09 37.0 0.8 16.6 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34877.1 - 9.6e-32 109.1 16.3 0.0011 19.2 0.0 12.9 1 1 13 14 14 14 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34877.1 - 1.1e-17 64.0 9.7 0.01 14.9 0.0 12.8 2 1 13 15 15 15 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34877.1 - 5.3e-14 52.2 25.6 0.0064 15.9 0.3 7.6 7 2 1 8 8 8 6 WD40-like domain Nup160 PF11715.8 ETO34877.1 - 1.3e-13 50.4 33.1 0.1 11.3 0.8 14.3 2 2 11 14 14 14 7 Nucleoporin Nup120/160 NACHT PF05729.12 ETO34877.1 - 3.2e-09 36.9 0.0 6.5e-09 35.9 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO34877.1 - 1.1e-07 31.4 2.6 2.4e-07 30.3 2.6 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO34877.1 - 1.1e-06 28.4 9.5 4.5 7.3 0.1 8.3 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO34877.1 - 0.00016 21.8 2.5 0.00048 20.2 2.5 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_22 PF13401.6 ETO34877.1 - 0.00021 21.6 0.1 0.001 19.4 0.1 2.2 1 1 0 1 1 1 1 AAA domain Mid2 PF04478.12 ETO34877.1 - 0.00025 20.9 5.8 7.6 6.4 0.0 6.8 4 2 1 6 6 6 1 Mid2 like cell wall stress sensor DUF3475 PF11961.8 ETO34877.1 - 0.00086 19.3 2.6 14 5.9 0.0 6.6 7 0 0 7 7 7 0 Domain of unknown function (DUF3475) AAA_18 PF13238.6 ETO34877.1 - 0.0027 18.3 0.0 0.0027 18.3 0.0 3.2 4 0 0 4 4 3 1 AAA domain Pentapeptide_3 PF13576.6 ETO34877.1 - 0.0032 17.6 1.4 0.0097 16.1 1.4 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA PF00004.29 ETO34877.1 - 0.005 17.3 0.1 0.18 12.2 0.0 2.5 2 0 0 2 2 2 1 ATPase family associated with various cellular activities (AAA) DUF1938 PF09153.10 ETO34877.1 - 0.027 14.6 0.4 19 5.4 0.0 4.2 4 0 0 4 4 4 0 Domain of unknown function (DUF1938) RsgA_GTPase PF03193.16 ETO34877.1 - 0.031 14.2 0.2 0.14 12.0 0.0 2.2 2 0 0 2 2 2 0 RsgA GTPase ABC_tran PF00005.27 ETO34877.1 - 0.088 13.3 0.8 0.37 11.3 0.0 2.5 2 0 0 2 2 2 0 ABC transporter Kelch_3 PF13415.6 ETO34878.1 - 1.1e-06 28.8 0.2 0.52 10.7 0.0 4.0 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO34878.1 - 4.1e-05 23.1 1.4 0.1 12.2 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO34878.1 - 0.00076 19.4 0.6 1 9.4 0.2 2.9 3 0 0 3 3 3 2 Kelch motif DUF1699 PF08004.11 ETO34878.1 - 0.0008 19.1 0.5 0.0016 18.1 0.0 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF1699) Kelch_6 PF13964.6 ETO34878.1 - 0.0018 18.5 0.8 0.79 10.1 0.1 3.5 2 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO34878.1 - 0.0079 16.2 0.2 0.79 9.8 0.0 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain BET PF17035.5 ETO34878.1 - 0.032 14.4 0.5 0.075 13.2 0.5 1.5 1 0 0 1 1 1 0 Bromodomain extra-terminal - transcription regulation WD40 PF00400.32 ETO34879.1 - 1.8e-21 76.0 3.1 2.1e-06 28.3 0.2 5.4 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34879.1 - 4.8e-10 39.6 0.3 0.075 13.3 0.0 4.8 1 1 4 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34879.1 - 4.1e-07 29.0 2.9 0.021 13.5 0.2 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34879.1 - 1.2e-05 24.8 5.5 0.0031 16.9 1.6 2.2 1 1 1 2 2 2 2 WD40-like domain DPPIV_N PF00930.21 ETO34879.1 - 0.00032 19.6 0.2 0.38 9.5 0.0 2.6 1 1 2 3 3 3 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PD40 PF07676.12 ETO34879.1 - 0.2 11.6 10.1 19 5.3 0.0 4.8 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO34880.1 - 4.6e-39 131.7 29.2 4.9e-06 27.2 0.3 8.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34880.1 - 1e-13 51.4 4.2 0.0041 17.4 0.0 5.5 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34880.1 - 2.8e-10 39.5 11.9 0.028 13.1 0.1 5.1 2 2 1 5 5 5 5 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO34880.1 - 0.00093 19.8 3.2 0.00093 19.8 3.2 2.8 3 0 0 3 3 3 1 TRAF-type zinc finger MyTH4 PF00784.17 ETO34880.1 - 0.29 11.6 4.5 0.65 10.5 0.7 2.6 2 1 0 2 2 2 0 MyTH4 domain DUF5305 PF17231.2 ETO34882.1 - 0.00078 18.9 3.2 0.0017 17.8 3.2 1.5 1 0 0 1 1 1 1 Family of unknown function (DUF5305) DUF1390 PF07150.11 ETO34882.1 - 0.065 12.9 0.1 0.065 12.9 0.1 2.2 3 0 0 3 3 3 0 Protein of unknown function (DUF1390) fn3 PF00041.21 ETO34882.1 - 0.095 13.1 4.7 0.13 12.6 0.5 3.3 2 1 1 3 3 3 0 Fibronectin type III domain Glycophorin_A PF01102.18 ETO34882.1 - 0.11 12.7 2.0 2.2 8.5 0.3 2.6 2 0 0 2 2 2 0 Glycophorin A DUF997 PF06196.12 ETO34882.1 - 0.21 11.6 0.1 0.21 11.6 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF997) G_glu_transpept PF01019.21 ETO34883.1 - 9e-34 117.1 0.0 1.1e-33 116.8 0.0 1.0 1 0 0 1 1 1 1 Gamma-glutamyltranspeptidase Dynein_C PF18199.1 ETO34884.1 - 6.3e-44 150.4 0.1 1.1e-43 149.7 0.1 1.4 1 0 0 1 1 1 1 Dynein heavy chain C-terminal domain Dynein_heavy PF03028.15 ETO34884.1 - 8.8e-30 103.2 0.0 3.5e-29 101.3 0.0 2.0 2 0 0 2 2 2 1 Dynein heavy chain region D6 P-loop domain AAA_lid_11 PF18198.1 ETO34884.1 - 1e-27 97.0 0.0 3.7e-27 95.1 0.1 2.0 2 0 0 2 2 2 1 Dynein heavy chain AAA lid domain Myb_Cef PF11831.8 ETO34885.1 - 0.0015 18.1 0.0 0.0021 17.7 0.0 1.1 1 0 0 1 1 1 1 pre-mRNA splicing factor component DUF3772 PF12607.8 ETO34885.1 - 0.14 12.0 2.0 0.21 11.4 2.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3772) Phage_int_SAM_4 PF13495.6 ETO34886.1 - 0.066 13.7 0.5 0.12 12.8 0.5 1.5 1 1 0 1 1 1 0 Phage integrase, N-terminal SAM-like domain Peptidase_C14 PF00656.22 ETO34886.1 - 0.093 12.7 0.1 0.14 12.1 0.1 1.1 1 0 0 1 1 1 0 Caspase domain Suc_Fer-like PF06999.12 ETO34886.1 - 0.15 11.9 0.1 0.18 11.6 0.1 1.2 1 0 0 1 1 1 0 Sucrase/ferredoxin-like Ank_2 PF12796.7 ETO34887.1 - 9.8e-22 77.3 4.9 5.6e-12 46.1 0.4 3.3 2 1 1 3 3 3 3 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO34887.1 - 5.1e-19 68.1 1.0 3.1e-09 36.9 0.0 4.2 4 0 0 4 4 4 2 Ankyrin repeats (many copies) Ank_4 PF13637.6 ETO34887.1 - 7.9e-17 61.4 1.0 0.00035 21.1 0.0 5.7 4 1 2 6 6 6 4 Ankyrin repeats (many copies) Ank PF00023.30 ETO34887.1 - 2.6e-14 52.9 0.0 0.0022 18.4 0.0 6.3 6 1 0 6 6 6 4 Ankyrin repeat Ank_3 PF13606.6 ETO34887.1 - 1.8e-10 40.1 4.4 0.082 13.5 0.0 6.2 6 0 0 6 6 6 3 Ankyrin repeat Kelch_6 PF13964.6 ETO34888.1 - 0.15 12.4 0.1 0.77 10.1 0.0 2.2 3 0 0 3 3 3 0 Kelch motif Kelch_6 PF13964.6 ETO34889.1 - 1.6e-05 25.0 0.7 0.00033 20.8 0.1 2.5 1 1 1 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO34889.1 - 0.0001 22.2 2.5 0.0011 18.9 0.0 2.6 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO34889.1 - 0.00055 19.5 0.1 0.0038 16.8 0.0 2.1 2 0 0 2 2 2 1 Kelch motif Kelch_3 PF13415.6 ETO34889.1 - 0.0056 16.9 0.0 0.024 14.9 0.0 2.1 2 0 0 2 2 2 1 Galactose oxidase, central domain FapA PF03961.13 ETO34889.1 - 0.011 14.4 5.8 0.013 14.2 5.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Kelch_5 PF13854.6 ETO34889.1 - 0.058 13.4 0.5 0.67 10.0 0.2 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_2 PF07646.15 ETO34889.1 - 0.1 12.6 0.3 2.8 8.1 0.1 2.6 2 0 0 2 2 2 0 Kelch motif Presenilin PF01080.17 ETO34891.1 - 0.59 8.8 3.7 0.79 8.4 3.7 1.1 1 0 0 1 1 1 0 Presenilin FAM176 PF14851.6 ETO34891.1 - 1.2 8.8 7.1 2.1 8.0 7.1 1.3 1 0 0 1 1 1 0 FAM176 family OSTbeta PF15048.6 ETO34891.1 - 9.8 6.3 11.5 0.31 11.2 3.0 2.1 1 1 1 2 2 2 0 Organic solute transporter subunit beta protein Kelch_1 PF01344.25 ETO34892.1 - 1.5e-05 24.4 3.7 0.021 14.4 0.6 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO34892.1 - 2e-05 24.3 6.9 0.0063 16.4 0.4 4.4 5 1 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO34892.1 - 0.00098 19.3 4.7 9.7 6.6 0.6 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_3 PF13415.6 ETO34892.1 - 0.0093 16.2 0.2 0.24 11.7 0.0 3.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO34892.1 - 0.033 14.2 3.5 0.3 11.1 0.1 3.2 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO34892.1 - 0.052 13.6 11.7 1.8 8.7 0.0 4.6 6 0 0 6 6 6 0 Kelch motif PsiE PF06146.12 ETO34893.1 - 0.64 10.4 2.3 0.72 10.3 0.5 1.9 2 0 0 2 2 2 0 Phosphate-starvation-inducible E Cupredoxin_1 PF13473.6 ETO34894.1 - 0.41 10.8 2.2 2.9 8.1 0.2 2.5 1 1 1 2 2 2 0 Cupredoxin-like domain CLASP_N PF12348.8 ETO34895.1 - 2.2e-06 27.4 0.1 2.7e-06 27.1 0.1 1.1 1 0 0 1 1 1 1 CLASP N terminal Tagatose_6_P_K PF08013.11 ETO34895.1 - 0.17 10.5 0.1 2.4 6.8 0.0 1.9 1 1 1 2 2 2 0 Tagatose 6 phosphate kinase CLASP_N PF12348.8 ETO34896.1 - 2.5e-10 40.3 3.3 0.0003 20.4 0.3 2.6 2 1 0 2 2 2 2 CLASP N terminal PH PF00169.29 ETO34897.1 - 8.7e-08 32.6 5.9 2.1e-06 28.2 0.6 3.6 3 1 0 3 3 3 1 PH domain SAM_1 PF00536.30 ETO34897.1 - 3.3e-07 30.7 0.1 6.3e-07 29.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO34897.1 - 9.3e-06 25.7 0.1 1.8e-05 24.7 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_PNT PF02198.16 ETO34897.1 - 0.002 18.0 0.2 0.004 17.1 0.2 1.5 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain PH_3 PF14593.6 ETO34897.1 - 0.0066 16.5 0.1 0.026 14.6 0.0 2.0 2 0 0 2 2 2 1 PH domain NADH_dehy_S2_C PF06444.11 ETO34897.1 - 0.7 10.5 3.4 2 9.0 3.4 1.7 1 0 0 1 1 1 0 NADH dehydrogenase subunit 2 C-terminus Aa_trans PF01490.18 ETO34898.1 - 3e-06 26.2 3.0 3e-06 26.2 3.0 1.8 2 0 0 2 2 2 1 Transmembrane amino acid transporter protein Trp_Tyr_perm PF03222.13 ETO34898.1 - 3.1e-05 23.2 0.6 4.8e-05 22.6 0.6 1.2 1 0 0 1 1 1 1 Tryptophan/tyrosine permease family Presenilin PF01080.17 ETO34899.1 - 0.39 9.4 4.2 0.46 9.2 4.2 1.1 1 0 0 1 1 1 0 Presenilin DUF5365 PF17326.2 ETO34900.1 - 0.17 12.3 2.4 0.3 11.5 0.5 2.2 2 0 0 2 2 2 0 Family of unknown function (DUF5365) R3H PF01424.22 ETO34906.1 - 0.043 13.8 0.0 0.11 12.5 0.0 1.7 1 0 0 1 1 1 0 R3H domain U-box PF04564.15 ETO34908.1 - 1.8e-10 40.8 0.6 7.9e-10 38.8 0.0 2.5 2 1 0 2 2 2 1 U-box domain Kelch_4 PF13418.6 ETO34908.1 - 0.00013 21.9 0.1 0.00062 19.7 0.0 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO34908.1 - 0.00044 20.4 0.1 0.011 15.9 0.1 2.8 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO34908.1 - 0.00044 19.8 0.3 0.0028 17.2 0.1 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO34908.1 - 0.088 13.1 0.1 0.36 11.2 0.0 2.1 3 0 0 3 3 3 0 Galactose oxidase, central domain DASH_Dad3 PF08656.10 ETO34908.1 - 0.2 11.8 2.2 23 5.2 0.4 3.0 2 0 0 2 2 2 0 DASH complex subunit Dad3 Kelch_5 PF13854.6 ETO34908.1 - 0.24 11.4 1.6 2.5 8.2 0.7 2.7 3 0 0 3 3 3 0 Kelch motif HEAT PF02985.22 ETO34909.1 - 2.1e-13 49.3 0.5 0.0089 16.2 0.0 6.5 7 0 0 7 7 5 2 HEAT repeat HEAT_2 PF13646.6 ETO34909.1 - 5.1e-09 36.4 0.0 0.047 14.1 0.0 4.3 3 2 2 5 5 5 3 HEAT repeats RTP1_C1 PF10363.9 ETO34909.1 - 5.4e-08 33.0 2.9 0.03 14.5 0.0 4.8 1 1 4 5 5 5 2 Required for nuclear transport of RNA pol II C-terminus 1 TIP120 PF08623.10 ETO34909.1 - 5.9e-06 26.1 10.2 0.17 11.7 0.0 5.0 3 2 2 5 5 5 2 TATA-binding protein interacting (TIP20) MMS19_N PF14500.6 ETO34909.1 - 3.5e-05 23.5 3.3 0.0031 17.1 0.6 3.9 1 1 1 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Cnd1 PF12717.7 ETO34909.1 - 0.00047 20.2 15.1 0.39 10.8 0.0 4.8 1 1 4 5 5 5 2 non-SMC mitotic condensation complex subunit 1 Vac14_Fab1_bd PF12755.7 ETO34909.1 - 0.0014 19.1 7.2 1 10.0 0.1 5.0 3 2 2 5 5 5 1 Vacuolar 14 Fab1-binding region BRCA-2_OB3 PF09104.10 ETO34909.1 - 0.0038 16.9 2.3 0.068 12.8 0.3 3.4 4 0 0 4 4 4 1 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 HEAT_EZ PF13513.6 ETO34909.1 - 0.0096 16.4 0.0 1.8 9.2 0.0 3.1 3 0 0 3 3 3 1 HEAT-like repeat IPK PF03770.16 ETO34909.1 - 0.049 13.5 3.8 0.11 12.3 0.1 3.0 3 1 0 3 3 3 0 Inositol polyphosphate kinase LapD_MoxY_N PF16448.5 ETO34909.1 - 0.077 12.9 0.1 1.2 9.0 0.0 2.3 2 0 0 2 2 2 0 LapD/MoxY periplasmic domain DNA_pol3_gamma3 PF12169.8 ETO34909.1 - 0.1 12.5 0.0 8 6.4 0.0 3.4 3 1 0 3 3 3 0 DNA polymerase III subunits gamma and tau domain III DUF3944 PF13099.6 ETO34909.1 - 0.13 12.2 2.9 6.6 6.7 0.0 4.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3944) CCDC-167 PF15188.6 ETO34909.1 - 0.38 11.1 4.4 28 5.1 0.1 3.8 3 0 0 3 3 3 0 Coiled-coil domain-containing protein 167 DUF2670 PF10875.8 ETO34909.1 - 0.89 9.7 4.7 8.9 6.4 0.2 3.5 3 0 0 3 3 3 0 Protein of unknown function (DUF2670) LuxT_C PF18285.1 ETO34909.1 - 1.4 9.5 7.3 3.6 8.2 0.3 4.3 5 0 0 5 5 5 0 Tetracycline repressor LuxT C-terminal domain DUF2543 PF10820.8 ETO34909.1 - 1.8 8.8 6.3 24 5.2 0.0 4.1 5 1 0 5 5 5 0 Protein of unknown function (DUF2543) ANAPC4_WD40 PF12894.7 ETO34911.1 - 0.005 17.1 0.0 0.18 12.1 0.0 2.4 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO34911.1 - 0.0068 16.3 0.2 3 7.9 0.0 2.6 2 0 0 2 2 2 2 WD40-like Beta Propeller Repeat N6_Mtase PF02384.16 ETO34912.1 - 9e-32 110.6 0.3 1.3e-30 106.7 0.3 2.0 1 1 0 1 1 1 1 N-6 DNA Methylase Methyltransf_31 PF13847.6 ETO34912.1 - 0.00033 20.5 0.0 0.0005 19.9 0.0 1.5 1 1 0 1 1 1 1 Methyltransferase domain UPF0020 PF01170.18 ETO34912.1 - 0.00033 20.4 0.0 0.001 18.8 0.0 1.8 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Eco57I PF07669.11 ETO34912.1 - 0.00059 20.3 0.2 0.0019 18.7 0.2 1.9 1 1 0 1 1 1 1 Eco57I restriction-modification methylase MTS PF05175.14 ETO34912.1 - 0.0014 18.2 0.0 0.005 16.4 0.0 2.0 1 1 0 1 1 1 1 Methyltransferase small domain PHB_acc_N PF07879.11 ETO34913.1 - 2.2e-26 91.7 3.4 4.9e-26 90.6 3.4 1.6 1 0 0 1 1 1 1 PHB/PHA accumulation regulator DNA-binding domain PHB_acc PF05233.13 ETO34913.1 - 1.1e-12 47.8 0.7 2.9e-12 46.4 0.1 2.2 3 0 0 3 3 3 1 PHB accumulation regulatory domain Proteasome PF00227.26 ETO34913.1 - 1.4e-09 37.7 0.0 7.7e-09 35.3 0.0 2.1 2 1 0 2 2 2 1 Proteasome subunit Pribosyltran PF00156.27 ETO34913.1 - 0.00076 19.0 0.0 0.0017 17.9 0.0 1.5 1 0 0 1 1 1 1 Phosphoribosyl transferase domain FF PF01846.19 ETO34913.1 - 0.084 13.1 0.5 0.54 10.5 0.2 2.5 3 0 0 3 3 3 0 FF domain TPK_catalytic PF04263.16 ETO34914.1 - 1.7e-09 37.8 0.2 4e-09 36.6 0.2 1.6 1 0 0 1 1 1 1 Thiamin pyrophosphokinase, catalytic domain PGAP1 PF07819.13 ETO34914.1 - 5.3e-05 23.0 0.0 0.0033 17.2 0.0 2.9 3 0 0 3 3 3 1 PGAP1-like protein PhaC_N PF07167.13 ETO34914.1 - 0.00016 21.4 0.4 0.00036 20.2 0.2 1.8 2 0 0 2 2 2 1 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus DUF3141 PF11339.8 ETO34914.1 - 0.0027 16.2 0.2 0.0083 14.6 0.1 1.7 2 0 0 2 2 2 1 Protein of unknown function (DUF3141) Abhydrolase_1 PF00561.20 ETO34914.1 - 0.0074 16.0 0.0 0.021 14.5 0.0 1.7 1 1 0 1 1 1 1 alpha/beta hydrolase fold FTH PF01827.27 ETO34914.1 - 0.0095 15.7 2.6 0.023 14.5 0.4 2.6 3 0 0 3 3 3 1 FTH domain TPK_B1_binding PF04265.14 ETO34914.1 - 0.042 13.6 0.0 0.11 12.3 0.0 1.7 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, vitamin B1 binding domain Hydrolase_4 PF12146.8 ETO34914.1 - 0.046 13.0 0.0 0.088 12.1 0.0 1.4 1 0 0 1 1 1 0 Serine aminopeptidase, S33 DLH PF01738.18 ETO34914.1 - 0.063 12.8 0.0 0.16 11.5 0.0 1.6 1 0 0 1 1 1 0 Dienelactone hydrolase family Esterase PF00756.20 ETO34914.1 - 0.064 12.9 0.0 0.1 12.2 0.0 1.2 1 0 0 1 1 1 0 Putative esterase OMP_b-brl PF13505.6 ETO34915.1 - 1.7e-11 44.6 1.4 1.7e-11 44.6 1.4 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain OMP_b-brl_2 PF13568.6 ETO34915.1 - 0.0011 19.0 2.7 0.0081 16.2 2.7 1.9 1 1 0 1 1 1 1 Outer membrane protein beta-barrel domain CsiV PF10972.8 ETO34915.1 - 0.086 12.5 0.0 0.11 12.2 0.0 1.1 1 0 0 1 1 1 0 Peptidoglycan-binding protein, CsiV OMP_b-brl PF13505.6 ETO34916.1 - 2.8e-13 50.4 1.6 3.3e-13 50.1 1.6 1.1 1 0 0 1 1 1 1 Outer membrane protein beta-barrel domain DUF4177 PF13783.6 ETO34916.1 - 0.032 14.5 0.0 0.19 12.1 0.0 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4177) Rep_3 PF01051.21 ETO34917.1 - 0.0024 17.7 0.4 0.0024 17.7 0.4 1.6 2 0 0 2 2 2 1 Initiator Replication protein UDPG_MGDP_dh_N PF03721.14 ETO34918.1 - 9.3e-27 93.8 0.5 1.2e-26 93.4 0.5 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh PF00984.19 ETO34918.1 - 5.3e-16 58.6 0.0 1.3e-15 57.4 0.0 1.7 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, central domain Glycos_transf_1 PF00534.20 ETO34919.1 - 5.6e-22 78.1 0.0 9.8e-22 77.3 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_4 PF13692.6 ETO34919.1 - 2.7e-14 53.7 0.0 4.9e-14 52.9 0.0 1.3 1 0 0 1 1 1 1 Glycosyl transferases group 1 Glyco_trans_1_2 PF13524.6 ETO34919.1 - 0.033 14.6 0.0 0.069 13.5 0.0 1.5 1 0 0 1 1 1 0 Glycosyl transferases group 1 Glyco_transf_20 PF00982.21 ETO34919.1 - 0.033 12.8 0.0 0.062 12.0 0.0 1.3 1 0 0 1 1 1 0 Glycosyltransferase family 20 SIS PF01380.22 ETO34920.1 - 6.9e-53 178.0 0.5 1.1e-28 99.8 0.2 2.7 3 0 0 3 3 3 2 SIS domain GATase_6 PF13522.6 ETO34920.1 - 1.7e-10 41.2 0.0 3e-10 40.4 0.0 1.3 1 0 0 1 1 1 1 Glutamine amidotransferase domain GATase_7 PF13537.6 ETO34920.1 - 3.2e-10 40.0 0.0 9.6e-10 38.4 0.0 1.8 1 0 0 1 1 1 1 Glutamine amidotransferase domain SIS_2 PF13580.6 ETO34920.1 - 0.058 13.4 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 SIS domain DUF240 PF03086.14 ETO34923.1 - 0.067 13.1 0.6 1.7 8.6 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF240) DnaJ PF00226.31 ETO34925.1 - 0.00093 19.3 0.0 0.0017 18.4 0.0 1.5 1 0 0 1 1 1 1 DnaJ domain Pam16 PF03656.13 ETO34925.1 - 0.0047 16.9 0.0 0.0065 16.5 0.0 1.2 1 0 0 1 1 1 1 Pam16 OAD_gamma PF04277.13 ETO34925.1 - 6.5 7.4 6.2 13 6.4 6.2 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Tubulin_C PF03953.17 ETO34926.1 - 3.3e-12 46.7 0.1 4.7e-12 46.2 0.1 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain VanZ PF04892.12 ETO34927.1 - 0.022 15.4 0.5 0.036 14.7 0.5 1.4 1 0 0 1 1 1 0 VanZ like family OAD_gamma PF04277.13 ETO34927.1 - 0.058 14.0 0.0 0.12 13.0 0.0 1.5 1 0 0 1 1 1 0 Oxaloacetate decarboxylase, gamma chain Zip PF02535.22 ETO34927.1 - 0.59 9.3 2.2 1.1 8.4 2.2 1.5 1 1 0 1 1 1 0 ZIP Zinc transporter WD40 PF00400.32 ETO34928.1 - 4.3e-15 55.9 1.2 9.6e-06 26.3 0.0 3.9 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34928.1 - 9e-05 22.7 0.3 0.13 12.6 0.0 2.8 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34928.1 - 0.00055 18.7 0.5 0.24 10.0 0.0 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 BofC_C PF08955.10 ETO34928.1 - 0.034 14.2 0.1 16 5.6 0.0 2.9 2 1 1 3 3 3 0 BofC C-terminal domain SGS PF05002.15 ETO34929.1 - 9.6e-28 96.1 4.7 2.1e-27 95.0 4.7 1.6 1 0 0 1 1 1 1 SGS domain CS PF04969.16 ETO34929.1 - 5e-09 37.0 0.6 5e-09 37.0 0.6 1.8 3 0 0 3 3 3 1 CS domain IHHNV_capsid PF16530.5 ETO34929.1 - 0.074 12.2 0.0 0.097 11.8 0.0 1.2 1 0 0 1 1 1 0 Infectious hypodermal and haematopoietic necrosis virus, capsid Jak1_Phl PF17887.1 ETO34929.1 - 0.37 10.8 0.0 0.37 10.8 0.0 2.3 2 1 0 2 2 2 0 Jak1 pleckstrin homology-like domain Arf PF00025.21 ETO34930.1 - 4.3e-75 251.0 0.1 5.1e-75 250.7 0.1 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family Roc PF08477.13 ETO34930.1 - 1.2e-13 51.3 0.0 1.9e-13 50.7 0.0 1.3 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Ras PF00071.22 ETO34930.1 - 1.6e-12 47.3 0.0 1.9e-12 47.0 0.0 1.1 1 0 0 1 1 1 1 Ras family SRPRB PF09439.10 ETO34930.1 - 2.1e-12 46.9 0.0 2.7e-12 46.5 0.0 1.2 1 0 0 1 1 1 1 Signal recognition particle receptor beta subunit G-alpha PF00503.20 ETO34930.1 - 5.3e-11 42.3 1.0 4.7e-08 32.6 0.1 2.4 1 1 1 2 2 2 2 G-protein alpha subunit Gtr1_RagA PF04670.12 ETO34930.1 - 2.3e-08 33.7 0.0 2.8e-08 33.4 0.0 1.1 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO34930.1 - 4.6e-05 23.5 0.2 9e-05 22.5 0.2 1.6 1 1 0 1 1 1 1 50S ribosome-binding GTPase 6PF2K PF01591.18 ETO34930.1 - 0.029 13.7 0.1 0.05 12.9 0.1 1.3 1 0 0 1 1 1 0 6-phosphofructo-2-kinase AAA_33 PF13671.6 ETO34930.1 - 0.12 12.5 0.3 0.23 11.6 0.3 1.7 1 1 0 1 1 1 0 AAA domain RsgA_GTPase PF03193.16 ETO34930.1 - 0.13 12.1 0.2 1.6 8.6 0.0 2.1 2 0 0 2 2 2 0 RsgA GTPase cobW PF02492.19 ETO34930.1 - 0.15 11.6 0.3 0.97 9.0 0.0 1.9 2 0 0 2 2 2 0 CobW/HypB/UreG, nucleotide-binding domain zf-RING_11 PF17123.5 ETO34931.1 - 3e-10 39.7 3.5 1e-09 37.9 3.5 2.0 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ETO34931.1 - 8.3e-08 32.4 5.3 8.3e-08 32.4 5.3 2.4 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO34931.1 - 0.00028 20.7 1.4 0.0008 19.2 1.4 1.8 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO34931.1 - 0.0021 18.0 1.7 0.0021 18.0 1.7 2.2 2 0 0 2 2 2 1 RING-type zinc-finger Zip PF02535.22 ETO34931.1 - 0.0027 17.0 0.0 0.0044 16.3 0.0 1.3 1 0 0 1 1 1 1 ZIP Zinc transporter Folate_carrier PF01770.18 ETO34931.1 - 0.0036 16.1 0.0 0.0059 15.4 0.0 1.3 1 0 0 1 1 1 1 Reduced folate carrier zf-rbx1 PF12678.7 ETO34931.1 - 1.3 9.4 8.6 0.1 12.9 3.0 2.2 2 1 0 2 2 2 0 RING-H2 zinc finger domain Beta_helix PF13229.6 ETO34932.1 - 0.007 16.2 16.3 0.007 16.2 16.3 6.1 2 2 2 5 5 5 3 Right handed beta helix region GHL15 PF14885.6 ETO34932.1 - 0.022 14.7 0.0 0.045 13.7 0.0 1.5 1 0 0 1 1 1 0 Hypothetical glycosyl hydrolase family 15 PT PF04886.12 ETO34933.1 - 4.2e-37 125.4 129.3 0.0028 17.1 14.0 8.5 1 1 2 3 3 3 2 PT repeat NACHT PF05729.12 ETO34934.1 - 2.1e-08 34.2 0.0 4.8e-08 33.1 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO34934.1 - 0.0026 18.3 0.0 0.046 14.3 0.0 2.7 2 0 0 2 2 2 1 AAA domain AAA_22 PF13401.6 ETO34934.1 - 0.016 15.4 0.0 0.044 14.1 0.0 1.8 1 0 0 1 1 1 0 AAA domain Com_YlbF PF06133.11 ETO34935.1 - 0.037 14.6 1.8 0.037 14.6 1.8 2.4 2 1 0 2 2 2 0 Control of competence regulator ComK, YlbF/YmcA zf-Mss51 PF13824.6 ETO34935.1 - 0.1 12.7 0.0 0.2 11.8 0.0 1.8 1 0 0 1 1 1 0 Zinc-finger of mitochondrial splicing suppressor 51 RNF220 PF15926.5 ETO34936.1 - 7.7e-06 25.7 13.9 0.0058 16.3 0.9 3.3 2 1 0 3 3 3 2 E3 ubiquitin-protein ligase RNF220 zf-WRNIP1_ubi PF18279.1 ETO34936.1 - 3.3e-05 24.2 11.4 0.35 11.6 0.9 3.5 3 0 0 3 3 3 3 Werner helicase-interacting protein 1 ubiquitin-binding domain zf-TRAF PF02176.18 ETO34936.1 - 0.00048 20.7 11.8 0.1 13.3 1.4 3.3 3 0 0 3 3 3 1 TRAF-type zinc finger Prok-RING_4 PF14447.6 ETO34936.1 - 0.0027 17.5 3.3 7 6.6 0.1 3.5 3 0 0 3 3 3 2 Prokaryotic RING finger family 4 zf_UBZ PF18439.1 ETO34936.1 - 0.0055 16.3 8.6 0.52 10.0 0.0 4.1 4 0 0 4 4 4 1 Ubiquitin-Binding Zinc Finger zf-ribbon_3 PF13248.6 ETO34936.1 - 0.008 15.6 3.4 1.2 8.6 0.1 3.4 3 0 0 3 3 3 1 zinc-ribbon domain zf-Di19 PF05605.12 ETO34936.1 - 0.018 15.4 10.2 3.2 8.1 1.1 3.4 3 0 0 3 3 3 0 Drought induced 19 protein (Di19), zinc-binding Sfi1_C PF10638.9 ETO34936.1 - 0.071 13.9 0.2 0.26 12.1 0.1 2.0 1 1 0 1 1 1 0 Spindle body associated protein C-terminus zf-C6H2 PF15801.5 ETO34936.1 - 0.12 12.7 5.5 9.9 6.6 0.1 3.4 3 0 0 3 3 3 0 zf-MYND-like zinc finger, mRNA-binding DNA_ligase_ZBD PF03119.16 ETO34936.1 - 0.16 12.0 3.2 24 5.1 0.0 3.3 3 0 0 3 3 3 0 NAD-dependent DNA ligase C4 zinc finger domain zf-C3HC4_3 PF13920.6 ETO34936.1 - 0.19 11.6 5.4 20 5.1 0.1 3.4 3 0 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) Ribosomal_L32p PF01783.23 ETO34936.1 - 0.27 11.5 1.3 0.73 10.1 0.1 2.3 2 0 0 2 2 2 0 Ribosomal L32p protein family Sgf11 PF08209.11 ETO34936.1 - 0.42 10.2 5.9 3.1 7.4 0.1 3.4 3 1 0 3 3 3 0 Sgf11 (transcriptional regulation protein) YacG PF03884.14 ETO34936.1 - 0.48 10.2 6.2 15 5.4 0.2 3.4 3 0 0 3 3 3 0 DNA gyrase inhibitor YacG TRAF6_Z2 PF18048.1 ETO34936.1 - 0.93 9.6 11.7 0.23 11.6 2.2 3.4 3 0 0 3 3 3 0 TNF receptor-associated factor 6 zinc finger 2 RPA_interact_C PF14768.6 ETO34936.1 - 1.2 9.7 9.7 22 5.7 0.1 3.7 2 1 0 3 3 3 0 Replication protein A interacting C-terminal zf-C2H2_9 PF16293.5 ETO34936.1 - 3.1 7.7 8.0 40 4.2 0.3 3.4 3 0 0 3 3 3 0 C2H2 type zinc-finger (1 copy) zf-RING_5 PF14634.6 ETO34936.1 - 5.1 7.1 6.4 61 3.7 0.1 3.4 3 0 0 3 3 3 0 zinc-RING finger domain NACHT PF05729.12 ETO34937.1 - 2.8e-20 72.9 0.0 4.8e-20 72.1 0.0 1.4 1 0 0 1 1 1 1 NACHT domain NB-ARC PF00931.22 ETO34937.1 - 1.7e-06 27.4 2.9 6.4e-06 25.5 1.0 2.5 1 1 0 2 2 2 1 NB-ARC domain AAA_16 PF13191.6 ETO34937.1 - 0.011 16.2 0.0 0.063 13.7 0.0 2.2 1 1 0 1 1 1 0 AAA ATPase domain AAA_22 PF13401.6 ETO34937.1 - 0.045 14.0 0.0 0.37 11.1 0.0 2.3 1 1 0 1 1 1 0 AAA domain RNA_helicase PF00910.22 ETO34937.1 - 0.065 13.6 0.1 1.3 9.4 0.0 2.6 2 0 0 2 2 2 0 RNA helicase AAA_7 PF12775.7 ETO34937.1 - 0.086 12.4 0.1 0.67 9.4 0.0 2.2 2 0 0 2 2 2 0 P-loop containing dynein motor region PhoH PF02562.16 ETO34937.1 - 0.12 11.8 0.0 3.1 7.2 0.0 2.2 2 0 0 2 2 2 0 PhoH-like protein PC_rep PF01851.22 ETO34938.1 - 5.5e-08 32.8 3.3 4.5e-05 23.7 0.0 4.2 4 1 0 4 4 4 2 Proteasome/cyclosome repeat Adaptin_N PF01602.20 ETO34938.1 - 0.18 10.3 0.0 0.29 9.6 0.0 1.2 1 0 0 1 1 1 0 Adaptin N terminal region THOC7 PF05615.13 ETO34939.1 - 0.038 14.3 2.8 0.12 12.7 1.7 2.0 1 1 1 2 2 2 0 Tho complex subunit 7 DUF2203 PF09969.9 ETO34939.1 - 0.059 14.1 1.0 0.15 12.8 0.6 1.9 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) GrpE PF01025.19 ETO34939.1 - 0.08 12.6 3.3 0.11 12.1 3.3 1.1 1 0 0 1 1 1 0 GrpE DUF155 PF02582.14 ETO34939.1 - 0.087 12.9 2.6 0.15 12.2 2.6 1.3 1 0 0 1 1 1 0 Uncharacterised ACR, YagE family COG1723 ZapB PF06005.12 ETO34939.1 - 1.1 9.8 6.3 0.29 11.6 2.2 2.1 2 1 1 3 3 3 0 Cell division protein ZapB SAM_2 PF07647.17 ETO34940.1 - 0.042 14.0 0.0 0.069 13.3 0.0 1.3 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DUF4296 PF14129.6 ETO34940.1 - 0.048 14.3 1.6 0.094 13.3 1.6 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4296) ORC6 PF05460.13 ETO34940.1 - 0.25 10.6 14.2 0.27 10.5 14.2 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) PhoLip_ATPase_C PF16212.5 ETO34941.1 - 4.7e-78 262.4 25.6 4.7e-78 262.4 25.6 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Cation_ATPase PF13246.6 ETO34941.1 - 1.7e-11 44.1 0.2 1.4e-10 41.1 0.1 2.4 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO34941.1 - 7.9e-11 42.6 0.8 0.0025 18.1 0.1 3.3 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Hydrolase_3 PF08282.12 ETO34941.1 - 0.0046 16.7 5.4 0.0064 16.3 0.4 2.9 2 1 0 2 2 2 1 haloacid dehalogenase-like hydrolase E1-E2_ATPase PF00122.20 ETO34942.1 - 0.0016 18.0 0.0 0.0022 17.6 0.0 1.2 1 0 0 1 1 1 1 E1-E2 ATPase WD40 PF00400.32 ETO34943.1 - 1.1e-22 79.9 12.8 6.9e-07 29.9 0.8 5.8 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34943.1 - 8.8e-09 35.6 0.6 0.021 15.1 0.0 3.8 3 1 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO34943.1 - 5e-06 25.4 2.2 0.23 10.0 0.1 3.8 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34943.1 - 8.5e-05 22.0 12.9 0.018 14.3 0.3 4.0 2 1 2 4 4 4 3 WD40-like domain PX PF00787.24 ETO34944.1 - 1e-06 28.7 0.4 2.3e-06 27.5 0.4 1.6 1 1 0 1 1 1 1 PX domain Presenilin PF01080.17 ETO34945.1 - 0.069 11.9 13.1 0.097 11.4 13.1 1.3 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO34945.1 - 0.42 9.8 8.1 0.51 9.5 8.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO34945.1 - 3.3 5.9 25.5 4.4 5.5 25.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Nop14 PF04147.12 ETO34945.1 - 3.9 5.6 27.4 4.9 5.3 27.4 1.1 1 0 0 1 1 1 0 Nop14-like family PNISR PF15996.5 ETO34945.1 - 4.2 7.6 26.0 5.9 7.1 26.0 1.1 1 0 0 1 1 1 0 Arginine/serine-rich protein PNISR RP-C_C PF11800.8 ETO34945.1 - 6.1 6.9 10.5 11 6.0 10.5 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region MCM_bind PF09739.9 ETO34945.1 - 6.5 5.1 16.9 11 4.3 16.9 1.4 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Suf PF05843.14 ETO34945.1 - 7.1 6.5 14.3 10 6.0 14.3 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) DUF2151 PF10221.9 ETO34945.1 - 8.4 4.8 20.4 2.3 6.7 17.4 1.5 2 0 0 2 2 2 0 Cell cycle and development regulator Pullulanase_Ins PF18494.1 ETO34947.1 - 0.021 15.3 0.6 0.62 10.6 0.1 3.0 2 0 0 2 2 2 0 Pullulanase Ins domain UBA PF00627.31 ETO34949.1 - 1.5e-14 53.6 0.8 3.7e-06 26.7 0.0 2.9 2 0 0 2 2 2 2 UBA/TS-N domain HOIP-UBA PF16678.5 ETO34949.1 - 2.6e-05 24.3 2.4 2.6e-05 24.3 2.4 1.9 1 1 1 2 2 2 1 HOIP UBA domain pair UBA_4 PF14555.6 ETO34949.1 - 0.0032 17.2 0.0 0.023 14.5 0.0 2.2 2 0 0 2 2 2 1 UBA-like domain XRN_M PF17846.1 ETO34949.1 - 0.033 13.1 8.1 0.057 12.4 8.1 1.3 1 0 0 1 1 1 0 Xrn1 helical domain BT1 PF03092.16 ETO34949.1 - 0.068 11.4 4.5 0.096 10.9 4.5 1.2 1 0 0 1 1 1 0 BT1 family PhoU PF01895.19 ETO34949.1 - 0.95 10.0 9.2 5.6 7.5 0.5 3.4 2 1 1 3 3 3 0 PhoU domain Fzo_mitofusin PF04799.13 ETO34949.1 - 1.3 8.6 6.3 1 8.9 4.6 1.6 1 1 1 2 2 2 0 fzo-like conserved region DDHD PF02862.17 ETO34949.1 - 5.5 7.1 8.3 7.1 6.7 8.3 1.2 1 0 0 1 1 1 0 DDHD domain RR_TM4-6 PF06459.12 ETO34949.1 - 5.7 6.7 16.6 7.5 6.3 16.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 WD40 PF00400.32 ETO34951.1 - 6.6e-39 131.2 8.7 1.5e-10 41.5 0.1 5.7 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34951.1 - 3.9e-14 52.7 1.1 0.00082 19.6 0.0 4.2 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34951.1 - 9.4e-14 51.1 0.4 0.0016 17.5 0.1 4.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 ETO34951.1 - 0.0021 16.9 0.6 0.47 9.1 0.0 2.6 1 1 0 2 2 2 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region Nucleoporin_N PF08801.11 ETO34951.1 - 0.0042 15.9 4.3 0.061 12.1 0.4 2.8 1 1 1 3 3 3 1 Nup133 N terminal like DUF5570 PF17731.1 ETO34951.1 - 0.005 16.9 4.1 5.6 7.1 0.1 3.8 1 1 3 4 4 4 2 Family of unknown function (DUF5570) PD40 PF07676.12 ETO34951.1 - 0.026 14.5 0.3 7.3 6.7 0.0 3.0 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ETO34951.1 - 0.028 14.2 2.1 15 5.2 0.0 2.6 1 1 0 1 1 1 0 Lipoprotein LpqB beta-propeller domain SBD PF17882.1 ETO34951.1 - 0.045 13.6 0.8 3.1 7.6 0.3 3.1 1 1 1 2 2 2 0 OAA-family lectin sugar binding domain Proteasome_A_N PF10584.9 ETO34951.1 - 0.67 9.7 2.5 36 4.2 0.0 3.9 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature RhoGEF PF00621.20 ETO34952.1 - 1.6e-05 25.2 10.4 0.0003 21.1 4.4 2.5 2 1 0 2 2 2 1 RhoGEF domain Borrelia_P83 PF05262.11 ETO34952.1 - 0.00025 19.7 10.7 0.00029 19.5 10.7 1.2 1 0 0 1 1 1 1 Borrelia P83/100 protein Draxin PF15550.6 ETO34952.1 - 0.035 14.0 4.7 0.039 13.8 4.7 1.1 1 0 0 1 1 1 0 Draxin Macoilin PF09726.9 ETO34952.1 - 1.1 7.8 11.4 1.1 7.8 11.4 1.0 1 0 0 1 1 1 0 Macoilin family CDC45 PF02724.14 ETO34952.1 - 1.1 7.5 14.1 1.3 7.2 14.1 1.0 1 0 0 1 1 1 0 CDC45-like protein VSG_B PF13206.6 ETO34952.1 - 1.7 7.8 9.1 2 7.6 9.1 1.1 1 0 0 1 1 1 0 Trypanosomal VSG domain ALMT PF11744.8 ETO34952.1 - 1.8 7.3 4.5 2.3 7.0 4.5 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 ETO34952.1 - 3 7.6 12.5 3.9 7.2 12.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 AAA_11 PF13086.6 ETO34952.1 - 3.4 7.4 7.7 4 7.2 7.7 1.1 1 0 0 1 1 1 0 AAA domain Presenilin PF01080.17 ETO34952.1 - 4.1 6.1 4.8 4.1 6.1 4.8 1.1 1 0 0 1 1 1 0 Presenilin FmdE PF02663.14 ETO34952.1 - 7.9 6.5 8.1 13 5.8 8.1 1.3 1 0 0 1 1 1 0 FmdE, Molybdenum formylmethanofuran dehydrogenase operon Kelch_6 PF13964.6 ETO34953.1 - 6.9e-07 29.3 0.4 0.93 9.9 0.0 3.9 3 0 0 3 3 3 3 Kelch motif Kelch_5 PF13854.6 ETO34953.1 - 1.4e-06 28.2 1.5 0.022 14.7 0.8 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO34953.1 - 0.00049 19.6 0.8 0.0074 15.9 0.1 3.1 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO34953.1 - 0.00061 19.8 0.2 0.12 12.4 0.1 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO34953.1 - 0.057 12.6 0.1 0.31 10.2 0.0 2.0 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase WD40 PF00400.32 ETO34954.1 - 7.6e-66 216.5 17.5 1.1e-11 45.1 0.7 6.8 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34954.1 - 2.1e-25 88.8 2.6 0.00012 22.3 0.0 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34954.1 - 1e-14 54.3 0.1 0.0018 17.3 0.0 5.7 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO34954.1 - 2.9e-09 36.7 0.2 0.0032 16.9 0.4 3.9 1 1 3 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO34954.1 - 3.3e-08 32.6 2.1 0.51 8.9 0.0 5.6 3 2 3 6 6 6 3 Nucleoporin Nup120/160 PD40 PF07676.12 ETO34954.1 - 1.8e-05 24.5 0.9 10 6.2 0.0 5.6 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO34954.1 - 3.2e-05 24.0 4.2 6.8 6.8 0.0 5.5 1 1 5 6 6 6 1 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO34954.1 - 6.7e-05 22.4 2.1 2.2 7.5 0.0 4.5 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal BBS2_Mid PF14783.6 ETO34954.1 - 0.0002 21.4 2.5 2.7 8.1 0.0 4.8 3 2 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DPPIV_N PF00930.21 ETO34954.1 - 0.00029 19.7 0.0 1.8 7.3 0.0 3.9 1 1 3 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ PF01011.21 ETO34954.1 - 0.0015 18.4 0.0 26 5.0 0.0 4.9 5 0 0 5 5 5 0 PQQ enzyme repeat Nucleoporin_N PF08801.11 ETO34954.1 - 0.0044 15.8 2.6 3.7 6.2 0.5 4.5 1 1 3 4 4 4 1 Nup133 N terminal like IKI3 PF04762.12 ETO34954.1 - 0.0046 15.0 0.0 0.0087 14.1 0.0 1.5 1 1 0 1 1 1 1 IKI3 family HARP PF07443.13 ETO34954.1 - 0.012 15.2 0.1 3.8 7.2 0.0 3.6 3 0 0 3 3 3 0 HepA-related protein (HARP) DHFR_2 PF06442.11 ETO34954.1 - 0.014 15.2 0.0 1.5 8.7 0.0 3.1 4 0 0 4 4 4 0 R67 dihydrofolate reductase Pectate_lyase22 PF14583.6 ETO34954.1 - 0.015 14.0 0.0 0.032 12.9 0.0 1.5 1 0 0 1 1 1 0 Oligogalacturonate lyase Proteasome_A_N PF10584.9 ETO34954.1 - 0.015 15.0 1.6 47 3.8 0.0 5.1 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF1797 PF08796.10 ETO34954.1 - 0.028 14.5 0.0 7.2 6.8 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) NHL PF01436.21 ETO34954.1 - 0.036 14.1 0.1 1.1 9.4 0.0 3.4 4 0 0 4 4 4 0 NHL repeat Frtz PF11768.8 ETO34954.1 - 0.084 11.2 0.0 0.29 9.4 0.0 1.9 2 1 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz DUF727 PF05303.12 ETO34954.1 - 0.097 12.7 0.0 4.4 7.4 0.0 2.9 2 2 1 3 3 3 0 Protein of unknown function (DUF727) DUF2255 PF10012.9 ETO34954.1 - 0.13 12.4 0.3 1.5 9.0 0.3 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2255) WD40 PF00400.32 ETO34956.1 - 1.6e-08 35.1 0.3 1.2e-07 32.3 0.4 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat UpxZ PF06603.11 ETO34956.1 - 0.061 13.6 0.0 0.08 13.2 0.0 1.2 1 0 0 1 1 1 0 UpxZ family of transcription anti-terminator antagonists PDZ_6 PF17820.1 ETO34957.1 - 7.1e-07 29.0 0.0 9e-06 25.4 0.0 2.8 4 0 0 4 4 4 1 PDZ domain SAM_1 PF00536.30 ETO34957.1 - 1.8e-06 28.3 0.0 3.7e-06 27.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO34957.1 - 1.3e-05 25.2 0.0 3e-05 24.0 0.0 1.7 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) PDZ_2 PF13180.6 ETO34957.1 - 0.00024 21.4 0.5 0.0011 19.2 0.0 2.3 3 0 0 3 3 3 1 PDZ domain PDZ PF00595.24 ETO34957.1 - 0.00048 20.4 0.1 0.0016 18.7 0.0 2.0 2 0 0 2 2 2 1 PDZ domain RNA_pol_3_Rpc31 PF11705.8 ETO34958.1 - 0.0089 16.3 9.8 0.014 15.6 9.8 1.3 1 0 0 1 1 1 1 DNA-directed RNA polymerase III subunit Rpc31 FAM176 PF14851.6 ETO34958.1 - 0.1 12.3 12.3 2.4 7.8 0.0 2.5 2 1 0 2 2 2 0 FAM176 family Nop14 PF04147.12 ETO34958.1 - 0.18 10.0 11.5 0.22 9.7 11.5 1.1 1 0 0 1 1 1 0 Nop14-like family Nucleo_P87 PF07267.11 ETO34958.1 - 0.31 9.8 3.0 0.33 9.8 3.0 1.2 1 0 0 1 1 1 0 Nucleopolyhedrovirus capsid protein P87 NOA36 PF06524.12 ETO34958.1 - 0.32 10.3 10.3 0.43 9.8 10.3 1.2 1 0 0 1 1 1 0 NOA36 protein PPP4R2 PF09184.11 ETO34958.1 - 0.35 10.4 9.8 0.39 10.3 9.8 1.1 1 0 0 1 1 1 0 PPP4R2 FYDLN_acid PF09538.10 ETO34958.1 - 0.86 10.3 12.4 1.5 9.6 12.4 1.3 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) Serinc PF03348.15 ETO34958.1 - 0.9 8.4 2.6 1.8 7.4 2.6 1.5 1 1 0 1 1 1 0 Serine incorporator (Serinc) Pox_Ag35 PF03286.14 ETO34958.1 - 1 9.1 12.6 1.6 8.5 12.6 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein RPN2_C PF18004.1 ETO34958.1 - 1.5 8.7 9.0 2.3 8.1 9.0 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain DNA_pol_phi PF04931.13 ETO34958.1 - 1.5 6.8 16.3 1.9 6.5 16.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO34958.1 - 6.6 4.9 13.7 8.6 4.5 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein DUF4820 PF16091.5 ETO34958.1 - 8.3 5.7 6.9 12 5.2 6.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) WD40 PF00400.32 ETO34959.1 - 4.5e-103 334.3 23.9 4.5e-09 36.8 0.0 12.3 12 0 0 12 12 12 12 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34959.1 - 5.1e-27 94.0 6.5 0.1 12.9 0.0 11.4 1 1 11 12 12 12 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34959.1 - 1.6e-23 83.2 3.7 0.54 9.2 0.0 10.5 1 1 9 10 10 10 10 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO34959.1 - 4.3e-13 48.8 16.6 0.58 8.7 0.0 9.6 2 2 5 9 9 9 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO34959.1 - 3.8e-10 39.6 0.0 1 8.6 0.0 5.9 2 2 2 6 6 6 4 WD40-like domain Str_synth PF03088.16 ETO34959.1 - 1.5e-06 28.3 0.1 20 5.4 0.0 7.5 7 2 2 9 9 9 0 Strictosidine synthase Nbas_N PF15492.6 ETO34959.1 - 4.7e-05 22.9 4.0 3.4 6.9 0.0 5.5 3 1 2 6 6 6 2 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO34959.1 - 9.6e-05 21.3 0.1 0.72 8.5 0.0 5.5 2 1 3 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF4072 PF13284.6 ETO34959.1 - 0.00036 20.9 0.0 13 6.3 0.0 6.7 9 0 0 9 9 9 1 Domain of unknown function (DUF4072) PD40 PF07676.12 ETO34959.1 - 0.00039 20.3 15.4 29 4.8 0.1 8.3 9 0 0 9 9 8 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO34959.1 - 0.001 17.9 14.3 0.035 12.9 0.4 6.2 2 2 3 6 6 6 1 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO34959.1 - 0.0014 17.3 3.1 0.9 8.0 0.2 4.6 1 1 4 7 7 7 2 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO34959.1 - 0.0049 15.8 5.9 0.81 8.5 0.0 5.2 3 2 1 6 6 6 1 Partner and localizer of BRCA2 WD40 domain Pectate_lyase22 PF14583.6 ETO34959.1 - 0.01 14.5 0.0 0.97 8.0 0.0 3.1 2 2 2 4 4 4 0 Oligogalacturonate lyase IL3Ra_N PF18611.1 ETO34960.1 - 0.0017 18.3 0.8 0.0029 17.6 0.8 1.4 1 0 0 1 1 1 1 IL-3 receptor alpha chain N-terminal domain PPR PF01535.20 ETO34961.1 - 1.8e-12 46.6 2.9 0.012 15.9 0.0 4.9 4 0 0 4 4 4 4 PPR repeat PPR_2 PF13041.6 ETO34961.1 - 5e-12 45.8 13.2 2.1e-07 31.0 0.2 5.0 4 1 2 6 6 6 4 PPR repeat family PPR_3 PF13812.6 ETO34961.1 - 1.5e-08 34.6 2.2 0.0058 16.7 0.0 4.4 2 1 2 4 4 4 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO34961.1 - 8.2e-07 28.6 2.3 0.0068 16.1 0.0 3.5 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 ETO34961.1 - 0.0059 16.0 0.4 0.017 14.5 0.4 1.7 1 1 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP DUF3636 PF12331.8 ETO34961.1 - 0.22 11.4 1.5 0.33 10.8 0.4 1.8 2 0 0 2 2 2 0 Protein of unknown function (DUF3636) Q_salvage PF10343.9 ETO34962.1 - 4.2e-12 46.2 3.0 7.3e-12 45.5 1.1 2.0 2 0 0 2 2 2 1 Potential Queuosine, Q, salvage protein family DRMBL PF07522.14 ETO34962.1 - 0.013 15.7 0.0 0.06 13.5 0.0 2.1 1 1 1 2 2 2 0 DNA repair metallo-beta-lactamase SH2_2 PF14633.6 ETO34963.1 - 1e-71 240.8 1.2 1.2e-71 240.6 1.2 1.1 1 0 0 1 1 1 1 SH2 domain SH2 PF00017.24 ETO34963.1 - 0.017 15.2 0.0 0.11 12.6 0.0 2.1 2 0 0 2 2 2 0 SH2 domain S1 PF00575.23 ETO34964.1 - 0.00054 20.3 0.0 0.0013 19.0 0.0 1.7 1 1 0 1 1 1 1 S1 RNA binding domain Phospholip_A2_2 PF05826.12 ETO34964.1 - 0.049 13.9 4.8 8.9 6.6 0.0 2.2 2 0 0 2 2 2 0 Phospholipase A2 Nitrate_red_del PF02613.15 ETO34964.1 - 0.11 12.5 0.0 0.53 10.3 0.0 1.8 2 0 0 2 2 2 0 Nitrate reductase delta subunit Cys_rich_VLP PF14194.6 ETO34965.1 - 0.013 15.6 0.2 0.038 14.1 0.2 1.8 1 0 0 1 1 1 0 Cysteine-rich VLP WD40 PF00400.32 ETO34966.1 - 4.4e-21 74.8 1.6 4.2e-09 36.9 0.1 3.4 2 1 0 2 2 2 2 WD domain, G-beta repeat Kelch_1 PF01344.25 ETO34966.1 - 2e-09 36.9 2.3 2.8e-06 26.8 0.2 3.3 3 0 0 3 3 3 2 Kelch motif ANAPC4_WD40 PF12894.7 ETO34966.1 - 2.3e-06 27.8 0.0 0.0099 16.2 0.0 3.8 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_5 PF13854.6 ETO34966.1 - 5.7e-06 26.2 7.9 0.2 11.7 0.1 4.4 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ETO34966.1 - 6.8e-06 26.2 6.4 0.35 11.2 0.2 3.8 3 0 0 3 3 3 3 Kelch motif Kelch_4 PF13418.6 ETO34966.1 - 0.00013 21.9 0.4 0.77 9.8 0.1 2.7 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO34966.1 - 0.0051 16.7 2.2 0.88 9.7 0.1 3.9 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO34966.1 - 0.0054 17.0 0.2 0.052 13.8 0.0 2.5 3 0 0 3 3 3 1 Galactose oxidase, central domain WIYLD PF10440.9 ETO34967.1 - 0.016 15.0 0.8 0.031 14.1 0.2 1.8 2 0 0 2 2 2 0 Ubiquitin-binding WIYLD domain PUF PF00806.19 ETO34968.1 - 1.6e-41 137.6 14.2 2.5e-06 26.9 0.1 7.8 8 0 0 8 8 8 7 Pumilio-family RNA binding repeat Presenilin PF01080.17 ETO34968.1 - 0.27 9.9 7.7 0.5 9.1 7.7 1.3 1 0 0 1 1 1 0 Presenilin WD40 PF00400.32 ETO34969.1 - 2.8e-25 88.1 8.3 5.1e-05 24.0 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34969.1 - 4.2e-07 30.2 1.6 0.011 16.0 0.4 3.9 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO34969.1 - 2.3e-06 27.2 6.2 0.00013 21.4 1.8 2.2 1 1 1 2 2 2 2 WD40-like domain eIF2A PF08662.11 ETO34969.1 - 1.1e-05 25.5 1.0 0.064 13.1 0.2 2.3 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO34969.1 - 7.3e-05 21.6 8.0 0.14 10.8 0.1 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO34969.1 - 0.0011 17.5 0.4 0.043 12.4 0.1 2.0 2 0 0 2 2 2 1 Cytochrome D1 heme domain Caudo_bapla_RBP PF08931.10 ETO34969.1 - 0.027 13.9 0.4 0.11 11.9 0.2 1.8 1 1 1 2 2 2 0 Receptor-binding protein of phage tail base-plate Siphoviridae, head ACI44 PF15270.6 ETO34969.1 - 0.028 14.6 0.2 2.5 8.3 0.0 2.5 2 0 0 2 2 2 0 Metallo-carboxypeptidase inhibitor BBS2_Mid PF14783.6 ETO34969.1 - 0.61 10.1 5.3 18 5.4 0.0 4.1 2 2 3 5 5 5 0 Ciliary BBSome complex subunit 2, middle region RhoGAP PF00620.27 ETO34970.1 - 0.037 13.8 0.2 0.066 13.0 0.2 1.4 1 0 0 1 1 1 0 RhoGAP domain WD40 PF00400.32 ETO34971.1 - 1.8e-37 126.6 27.9 4.3e-07 30.5 1.6 7.8 7 3 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO34971.1 - 4.2e-11 42.2 7.3 0.0015 17.3 0.0 5.5 2 2 4 6 6 6 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34971.1 - 1.5e-10 41.2 1.6 0.057 13.7 0.0 5.2 3 1 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain DUF998 PF06197.13 ETO34972.1 - 0.0054 16.4 11.5 0.23 11.0 0.1 2.5 2 1 0 2 2 2 2 Protein of unknown function (DUF998) DPM3 PF08285.11 ETO34972.1 - 6.3 7.1 6.5 2.5 8.4 0.9 2.6 2 0 0 2 2 2 0 Dolichol-phosphate mannosyltransferase subunit 3 (DPM3) DUF872 PF05915.12 ETO34972.1 - 7.1 6.8 8.0 0.31 11.2 1.0 2.3 2 1 1 3 3 3 0 Eukaryotic protein of unknown function (DUF872) HTH_23 PF13384.6 ETO34973.1 - 0.01 15.6 0.0 0.018 14.8 0.0 1.3 1 0 0 1 1 1 0 Homeodomain-like domain Terminase_5 PF06056.12 ETO34973.1 - 0.017 15.0 0.1 0.038 13.9 0.1 1.5 1 0 0 1 1 1 0 Putative ATPase subunit of terminase (gpP-like) zf-C6H2 PF15801.5 ETO34973.1 - 0.13 12.6 0.6 0.13 12.6 0.6 3.0 2 1 2 4 4 4 0 zf-MYND-like zinc finger, mRNA-binding Utp21 PF04192.12 ETO34974.1 - 0.011 15.2 6.7 0.012 15.1 6.7 1.0 1 0 0 1 1 1 0 Utp21 specific WD40 associated putative domain GOLD_2 PF13897.6 ETO34974.1 - 0.93 10.0 6.9 0.97 9.9 6.9 1.2 1 0 0 1 1 1 0 Golgi-dynamics membrane-trafficking FAM176 PF14851.6 ETO34974.1 - 1.1 8.9 13.5 1.2 8.8 13.5 1.1 1 0 0 1 1 1 0 FAM176 family RNase_H2_suC PF08615.11 ETO34974.1 - 1.6 8.9 9.2 1.9 8.7 9.2 1.1 1 0 0 1 1 1 0 Ribonuclease H2 non-catalytic subunit (Ylr154p-like) VEFS-Box PF09733.9 ETO34974.1 - 1.9 8.3 12.3 2.3 8.0 12.3 1.2 1 0 0 1 1 1 0 VEFS-Box of polycomb protein DUF4637 PF15470.6 ETO34974.1 - 3.6 7.3 11.8 4 7.1 11.8 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) MDM10 PF12519.8 ETO34974.1 - 4.7 6.0 12.6 4.5 6.0 12.6 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 DNA_pol_phi PF04931.13 ETO34974.1 - 9.5 4.2 18.7 9.6 4.2 18.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi Vps51 PF08700.11 ETO34976.1 - 0.002 18.2 1.0 0.002 18.2 1.0 2.5 2 2 0 2 2 2 1 Vps51/Vps67 COG5 PF10392.9 ETO34976.1 - 0.041 14.0 1.8 0.041 14.0 1.8 3.3 2 2 1 3 3 3 0 Golgi transport complex subunit 5 DotD PF16816.5 ETO34976.1 - 0.07 13.1 0.0 0.15 12.0 0.0 1.5 1 0 0 1 1 1 0 DotD protein FadA PF09403.10 ETO34976.1 - 0.08 13.4 2.1 0.19 12.2 2.1 1.7 1 0 0 1 1 1 0 Adhesion protein FadA z-alpha PF02295.17 ETO34976.1 - 0.27 11.3 1.6 0.35 10.9 0.3 2.0 2 0 0 2 2 2 0 Adenosine deaminase z-alpha domain Med9 PF07544.13 ETO34976.1 - 2.9 8.0 7.2 2.7 8.1 1.3 2.7 2 1 1 3 3 3 0 RNA polymerase II transcription mediator complex subunit 9 Rsm22 PF09243.10 ETO34978.1 - 1.7e-21 76.7 0.1 3.4e-17 62.6 0.0 3.1 2 1 0 2 2 2 2 Mitochondrial small ribosomal subunit Rsm22 DDE_Tnp_ISAZ013 PF07592.11 ETO34978.1 - 0.032 13.2 0.2 0.067 12.2 0.2 1.5 1 0 0 1 1 1 0 Rhodopirellula transposase DDE domain Get5_C PF18514.1 ETO34979.1 - 0.047 13.4 0.9 0.11 12.2 0.9 1.7 1 0 0 1 1 1 0 Get5 C-terminal domain SDA1 PF05285.12 ETO34981.1 - 0.93 8.9 29.7 0.18 11.2 19.1 2.8 2 0 0 2 2 2 0 SDA1 RPN2_C PF18004.1 ETO34981.1 - 4.5 7.2 28.1 0.027 14.4 13.3 3.2 3 0 0 3 3 3 0 26S proteasome regulatory subunit RPN2 C-terminal domain Rsc14 PF08586.10 ETO34981.1 - 5 8.0 12.2 3.5 8.5 2.3 3.4 3 0 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit TMEM51 PF15345.6 ETO34981.1 - 6.1 6.6 7.7 1.6 8.5 3.5 2.1 2 0 0 2 2 2 0 Transmembrane protein 51 VIR_N PF15912.5 ETO34981.1 - 9.3 5.8 10.2 22 4.5 10.2 1.6 1 0 0 1 1 1 0 Virilizer, N-terminal Zip PF02535.22 ETO34981.1 - 9.4 5.3 5.7 5.5 6.1 2.6 2.0 2 0 0 2 2 2 0 ZIP Zinc transporter PH PF00169.29 ETO34984.1 - 5.4e-16 59.0 1.4 2e-15 57.1 1.4 2.1 1 0 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO34984.1 - 8.6e-08 32.4 0.3 2e-07 31.2 0.3 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO34984.1 - 4.8e-07 30.1 7.5 0.00029 21.2 3.3 3.9 2 2 0 2 2 2 1 Pleckstrin homology domain PH_2 PF08458.10 ETO34984.1 - 0.026 14.9 0.6 0.026 14.9 0.6 2.6 2 1 0 2 2 2 0 Plant pleckstrin homology-like region CBM26 PF16738.5 ETO34985.1 - 0.082 13.2 0.3 0.17 12.2 0.0 1.7 2 0 0 2 2 2 0 Starch-binding module 26 DUF3566 PF12089.8 ETO34987.1 - 4.1 7.8 8.1 15 6.0 8.1 1.8 1 1 0 1 1 1 0 Transmembrane domain of unknown function (DUF3566) PUB PF09409.10 ETO34988.1 - 0.019 14.9 0.3 0.051 13.5 0.3 1.9 1 1 0 1 1 1 0 PUB domain TetR_N PF00440.23 ETO34988.1 - 0.086 12.6 0.6 0.3 10.9 0.1 2.0 2 0 0 2 2 2 0 Bacterial regulatory proteins, tetR family HSDR_N_2 PF13588.6 ETO34989.1 - 0.0061 16.5 0.2 0.007 16.4 0.2 1.2 1 0 0 1 1 1 1 Type I restriction enzyme R protein N terminus (HSDR_N) WD40 PF00400.32 ETO34990.1 - 1.6e-27 95.2 14.6 2.8e-08 34.3 0.9 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO34990.1 - 6.2e-09 35.0 0.3 0.008 14.9 0.5 3.2 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO34990.1 - 1.1e-08 35.3 0.1 0.0029 17.9 0.0 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO34990.1 - 0.00045 20.2 0.0 0.072 13.1 0.0 2.2 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ETO34990.1 - 0.0022 17.4 0.7 0.21 10.9 0.5 2.7 1 1 2 3 3 3 1 WD40-like domain Sulfatase PF00884.23 ETO34991.1 - 2.9e-05 23.6 0.0 3.7e-05 23.3 0.0 1.2 1 0 0 1 1 1 1 Sulfatase COesterase PF00135.28 ETO34992.1 - 3.9e-40 138.2 0.2 5.4e-40 137.7 0.2 1.2 1 0 0 1 1 1 1 Carboxylesterase family Abhydrolase_3 PF07859.13 ETO34992.1 - 0.0094 15.8 0.4 0.019 14.8 0.4 1.5 1 0 0 1 1 1 1 alpha/beta hydrolase fold COLFI PF01410.18 ETO34993.1 - 0.11 11.8 0.4 0.14 11.4 0.4 1.2 1 0 0 1 1 1 0 Fibrillar collagen C-terminal domain YbaJ PF10757.9 ETO34993.1 - 2 9.0 7.4 1.1 9.8 3.6 2.3 1 1 2 3 3 3 0 Biofilm formation regulator YbaJ PH PF00169.29 ETO34994.1 - 7.5e-05 23.2 1.0 0.00097 19.6 0.1 3.0 2 0 0 2 2 2 1 PH domain Ras PF00071.22 ETO34994.1 - 0.00037 20.1 0.1 0.0022 17.6 0.0 2.1 2 0 0 2 2 2 1 Ras family Mid2 PF04478.12 ETO34994.1 - 0.86 9.4 4.2 11 5.9 0.5 3.1 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor Voltage_CLC PF00654.20 ETO34995.1 - 1.8e-57 195.2 10.8 2.6e-57 194.7 10.8 1.2 1 0 0 1 1 1 1 Voltage gated chloride channel CBS PF00571.28 ETO34995.1 - 3.4e-08 33.8 0.0 0.0023 18.3 0.0 2.7 2 1 0 2 2 2 2 CBS domain Voltage_CLC PF00654.20 ETO34996.1 - 8.9e-27 94.3 5.9 1.8e-26 93.3 4.8 1.8 2 0 0 2 2 2 1 Voltage gated chloride channel Exo_endo_phos_2 PF14529.6 ETO34998.1 - 1.1e-10 41.4 1.2 2e-10 40.6 1.2 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase Nanovirus_C8 PF05629.11 ETO34998.1 - 0.014 15.5 0.2 0.12 12.5 0.0 2.0 1 1 1 2 2 2 0 Nanovirus component 8 (C8) protein C_LFY_FLO PF17538.2 ETO34998.1 - 0.067 12.7 0.1 0.11 12.0 0.1 1.4 1 0 0 1 1 1 0 DNA Binding Domain (C-terminal) Leafy/Floricaula WD40 PF00400.32 ETO34999.1 - 5.5e-49 163.1 9.5 9.5e-09 35.8 0.3 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO34999.1 - 2.2e-19 69.5 0.6 0.013 15.7 0.0 6.9 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO34999.1 - 4.7e-12 45.5 3.0 0.11 11.4 0.0 6.5 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO34999.1 - 6.1e-10 39.3 0.3 0.052 13.4 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO34999.1 - 9.4e-07 28.6 2.5 1.5 8.9 0.0 4.7 4 0 0 4 4 4 3 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO34999.1 - 0.00016 20.4 1.1 0.078 11.6 0.0 3.5 1 1 2 3 3 3 1 Nucleoporin Nup120/160 dCache_1 PF02743.18 ETO34999.1 - 0.0018 18.1 0.6 0.0056 16.5 0.3 2.0 2 0 0 2 2 2 1 Cache domain PQQ_2 PF13360.6 ETO34999.1 - 0.0026 17.4 0.5 0.016 14.8 0.5 2.1 1 1 0 1 1 1 1 PQQ-like domain Pik1 PF11522.8 ETO35000.1 - 0.00033 20.5 0.2 0.0026 17.7 0.0 2.4 2 0 0 2 2 2 1 Yeast phosphatidylinositol-4-OH kinase Pik1 Mso1_Sec1_bdg PF14475.6 ETO35000.1 - 0.068 12.8 0.1 0.16 11.6 0.1 1.6 1 0 0 1 1 1 0 Sec1-binding region of Mso1 PPR_3 PF13812.6 ETO35001.1 - 0.0054 16.8 0.3 0.014 15.4 0.1 1.8 1 1 1 2 2 2 1 Pentatricopeptide repeat domain EIF_2_alpha PF07541.12 ETO35001.1 - 0.046 13.8 0.1 0.055 13.6 0.1 1.3 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 2 alpha subunit Motilin_ghrelin PF04644.12 ETO35001.1 - 0.047 13.5 2.3 0.14 11.9 2.3 1.8 1 0 0 1 1 1 0 Motilin/ghrelin WD40 PF00400.32 ETO35002.1 - 3.4e-05 24.5 0.4 0.0028 18.4 0.2 2.8 2 0 0 2 2 2 1 WD domain, G-beta repeat AvrB_AvrC PF05394.11 ETO35002.1 - 0.058 12.6 0.1 0.062 12.5 0.1 1.1 1 0 0 1 1 1 0 Avirulence protein WD40 PF00400.32 ETO35003.1 - 2.6e-22 78.7 13.3 3.7e-07 30.7 0.5 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35003.1 - 8.1e-06 26.1 0.7 0.25 11.6 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35003.1 - 0.00011 21.0 0.3 0.1 11.2 0.0 2.7 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF2334 PF10096.9 ETO35004.1 - 0.16 11.6 0.0 0.25 10.9 0.0 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2334) Inositol_P PF00459.25 ETO35005.1 - 5.5e-13 49.1 0.1 6e-09 35.8 0.0 2.5 2 1 1 3 3 3 2 Inositol monophosphatase family WD40 PF00400.32 ETO35006.1 - 6.3e-34 115.5 28.2 1.6e-06 28.7 0.2 8.3 7 1 0 7 7 7 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO35006.1 - 4.1e-09 35.6 3.8 0.003 16.3 0.1 4.0 1 1 2 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35006.1 - 1e-08 35.3 1.8 0.075 13.3 0.0 5.6 3 2 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO35006.1 - 5.5e-07 30.2 3.1 2.1e-06 28.3 3.1 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger WD40_like PF17005.5 ETO35006.1 - 1e-05 25.1 1.4 0.084 12.2 0.1 3.5 2 1 1 3 3 3 2 WD40-like domain PQQ_3 PF13570.6 ETO35006.1 - 0.02 15.3 0.1 5.1 7.7 0.0 3.5 3 1 0 3 3 3 0 PQQ-like domain PQQ_2 PF13360.6 ETO35006.1 - 0.028 14.0 0.1 0.05 13.2 0.1 1.4 1 0 0 1 1 1 0 PQQ-like domain TSC22 PF01166.18 ETO35006.1 - 0.047 14.0 4.7 0.082 13.2 0.4 3.1 2 1 1 3 3 3 0 TSC-22/dip/bun family PQQ PF01011.21 ETO35006.1 - 0.1 12.6 0.2 1.1 9.3 0.1 2.5 2 0 0 2 2 2 0 PQQ enzyme repeat DUF4717 PF15838.5 ETO35006.1 - 0.26 11.3 0.0 0.26 11.3 0.0 2.6 4 0 0 4 4 3 0 Domain of unknown function (DUF4717) SprB PF13573.6 ETO35006.1 - 1.1 9.1 13.9 0.82 9.5 0.5 3.8 3 0 0 3 3 3 0 SprB repeat Acetone_carb_G PF08882.11 ETO35007.1 - 0.047 13.8 1.1 0.1 12.8 1.1 1.6 1 0 0 1 1 1 0 Acetone carboxylase gamma subunit DCA16 PF15349.6 ETO35007.1 - 0.059 12.9 0.6 0.094 12.3 0.6 1.3 1 0 0 1 1 1 0 DDB1- and CUL4-associated factor 16 WD40 PF00400.32 ETO35008.1 - 2.6e-34 116.7 34.6 3.4e-06 27.7 7.7 7.6 7 3 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35008.1 - 1.2e-11 44.8 0.6 0.57 10.5 0.0 5.9 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35008.1 - 3.1e-11 42.6 0.7 0.021 13.5 0.1 5.0 3 2 2 5 5 5 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO35008.1 - 2.4e-05 23.3 2.4 0.062 12.0 0.0 3.4 2 2 1 4 4 4 2 Nup133 N terminal like WD40_like PF17005.5 ETO35008.1 - 0.00019 20.9 2.6 0.38 10.0 0.0 4.1 3 2 0 3 3 3 2 WD40-like domain RicinB_lectin_2 PF14200.6 ETO35008.1 - 0.011 16.5 0.5 2.8 8.7 0.1 3.5 2 2 1 4 4 4 0 Ricin-type beta-trefoil lectin domain-like DUF4178 PF13785.6 ETO35008.1 - 0.09 12.9 0.0 13 5.9 0.0 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF4178) WD40 PF00400.32 ETO35009.1 - 1.1e-36 124.2 25.9 4.9e-07 30.4 0.8 7.2 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO35009.1 - 8.8e-12 44.4 6.1 0.00035 19.4 1.9 5.1 1 1 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35009.1 - 1.8e-09 37.8 0.6 0.37 11.1 0.0 5.4 5 1 1 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain BBS2_Mid PF14783.6 ETO35009.1 - 0.00026 21.0 0.2 0.15 12.1 0.0 4.0 4 0 0 4 4 4 1 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO35010.1 - 4.9e-33 112.6 32.4 6.9e-07 29.9 0.4 8.1 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35010.1 - 4.2e-09 36.6 0.2 0.0041 17.4 0.0 4.8 4 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35010.1 - 7.3e-07 28.2 3.8 0.021 13.5 0.1 4.2 2 2 3 5 5 5 3 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO35010.1 - 0.00015 22.4 3.6 0.0006 20.4 3.6 2.1 1 0 0 1 1 1 1 TRAF-type zinc finger Wzy_C PF04932.15 ETO35010.1 - 0.25 11.0 1.0 1.1 8.8 0.0 2.2 2 0 0 2 2 2 0 O-Antigen ligase HEAT PF02985.22 ETO35013.1 - 2.4e-12 46.0 2.7 0.0097 16.1 0.0 7.4 8 0 0 8 8 7 2 HEAT repeat HEAT_2 PF13646.6 ETO35013.1 - 6.7e-07 29.6 0.0 0.03 14.7 0.0 4.0 3 1 1 4 4 4 2 HEAT repeats Cnd1 PF12717.7 ETO35013.1 - 0.00029 20.9 20.0 0.006 16.6 0.8 4.7 1 1 3 4 4 4 3 non-SMC mitotic condensation complex subunit 1 MMS19_N PF14500.6 ETO35013.1 - 0.0013 18.4 2.7 0.014 15.0 0.1 3.3 2 2 0 3 3 3 1 Dos2-interacting transcription regulator of RNA-Pol-II Activator-TraM PF11657.8 ETO35013.1 - 0.005 16.7 0.3 0.014 15.3 0.3 1.7 1 0 0 1 1 1 1 Transcriptional activator TraM HEAT_EZ PF13513.6 ETO35013.1 - 0.012 16.1 0.0 9.4 6.9 0.0 3.7 4 0 0 4 4 4 0 HEAT-like repeat FGase PF05013.12 ETO35013.1 - 0.043 14.0 0.0 0.065 13.4 0.0 1.2 1 0 0 1 1 1 0 N-formylglutamate amidohydrolase MOR2-PAG1_C PF14225.6 ETO35013.1 - 0.062 13.2 2.6 0.94 9.3 0.3 3.1 2 1 1 3 3 3 0 Cell morphogenesis C-terminal Condensin2nSMC PF12422.8 ETO35013.1 - 0.074 13.2 5.3 3.3 7.9 0.2 3.5 3 1 0 3 3 3 0 Condensin II non structural maintenance of chromosomes subunit Anticodon_1 PF08264.13 ETO35013.1 - 0.09 12.7 0.9 0.36 10.8 0.0 2.6 2 1 1 3 3 3 0 Anticodon-binding domain of tRNA SirA PF10747.9 ETO35013.1 - 0.11 12.8 16.0 0.17 12.2 0.1 4.8 4 1 2 6 6 6 0 Sporulation inhibitor of replication protein SirA DUF4487 PF14868.6 ETO35013.1 - 0.12 11.2 8.2 0.68 8.7 0.1 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF4487) SAC3_GANP PF03399.16 ETO35013.1 - 0.18 11.1 8.0 0.17 11.2 0.2 3.3 3 2 1 4 4 4 0 SAC3/GANP family UPF0147 PF03685.13 ETO35013.1 - 1.6 8.8 4.1 5.9 7.0 0.2 3.5 3 1 1 4 4 4 0 Uncharacterised protein family (UPF0147) HSP70 PF00012.20 ETO35013.1 - 2 6.5 6.0 0.55 8.3 0.4 2.5 2 1 1 3 3 3 0 Hsp70 protein CLZ PF16526.5 ETO35014.1 - 0.034 14.5 0.5 0.79 10.1 0.0 2.3 1 1 0 2 2 2 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels DUF1015 PF06245.11 ETO35014.1 - 0.15 10.9 0.0 0.16 10.8 0.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1015) DUF5071 PF16804.5 ETO35015.1 - 0.0083 16.4 0.4 0.011 16.0 0.4 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF5071) WD40 PF00400.32 ETO35016.1 - 9.5e-143 459.8 61.5 1.3e-10 41.7 0.1 14.2 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35016.1 - 1.2e-48 163.3 0.9 0.00079 19.7 0.0 14.1 1 1 13 14 14 14 13 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35016.1 - 6.9e-32 111.0 0.0 0.00053 19.4 0.0 8.3 4 3 4 8 8 8 8 WD40-like domain Ge1_WD40 PF16529.5 ETO35016.1 - 1.9e-23 83.0 2.6 2.3 7.1 0.0 13.2 1 1 13 14 14 14 7 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO35016.1 - 3.5e-16 58.7 17.4 12 5.9 0.1 13.1 13 0 0 13 13 13 0 WD40-like Beta Propeller Repeat PQQ_2 PF13360.6 ETO35016.1 - 9.2e-14 51.6 2.9 0.0093 15.6 0.1 5.5 2 2 1 3 3 3 3 PQQ-like domain Nup160 PF11715.8 ETO35016.1 - 1.4e-09 37.2 15.5 2.5 6.7 0.0 10.3 3 3 7 11 11 11 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO35016.1 - 1.1e-07 30.8 4.1 0.23 9.9 0.1 5.5 3 1 1 5 5 5 1 Cytochrome D1 heme domain DUF727 PF05303.12 ETO35016.1 - 1.8e-07 31.2 0.0 2.1 8.5 0.0 8.6 3 3 8 11 11 11 1 Protein of unknown function (DUF727) Frtz PF11768.8 ETO35016.1 - 3.2e-07 29.0 0.0 2.5 6.3 0.0 7.0 5 2 3 8 8 8 2 WD repeat-containing and planar cell polarity effector protein Fritz Me-amine-dh_H PF06433.11 ETO35016.1 - 1.3e-06 27.6 0.0 1.5 7.6 0.0 4.9 3 1 2 5 5 5 2 Methylamine dehydrogenase heavy chain (MADH) Pentapeptide PF00805.22 ETO35016.1 - 9.7e-06 25.1 2.3 1.9e-05 24.2 2.3 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO35016.1 - 0.0015 18.6 0.1 0.0039 17.3 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PQQ PF01011.21 ETO35016.1 - 0.0016 18.3 0.0 1.2e+02 2.9 0.0 6.8 8 0 0 8 8 8 0 PQQ enzyme repeat TolB_N PF04052.13 ETO35016.1 - 0.0048 17.1 0.1 38 4.5 0.0 6.5 10 0 0 10 10 9 0 TolB amino-terminal domain DPPIV_N PF00930.21 ETO35016.1 - 0.0049 15.7 2.3 47 2.6 0.0 7.2 6 3 3 9 9 9 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Mid2 PF04478.12 ETO35016.1 - 0.0053 16.6 0.1 2 8.3 0.0 3.9 4 1 0 4 4 3 1 Mid2 like cell wall stress sensor Pentapeptide_3 PF13576.6 ETO35016.1 - 0.048 13.8 0.1 0.12 12.6 0.1 1.6 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) Proteasome_A_N PF10584.9 ETO35016.1 - 0.086 12.5 35.1 58 3.5 0.0 12.2 13 0 0 13 13 13 0 Proteasome subunit A N-terminal signature DUF3475 PF11961.8 ETO35016.1 - 0.15 12.1 0.1 58 3.9 0.0 4.1 4 0 0 4 4 3 0 Domain of unknown function (DUF3475) WD40 PF00400.32 ETO35017.1 - 1.1e-09 38.7 2.3 0.00054 20.7 0.3 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35017.1 - 0.00014 20.7 1.1 0.041 12.5 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35017.1 - 0.0014 18.8 0.1 0.67 10.3 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain TrbL PF04610.14 ETO35017.1 - 0.18 11.6 0.2 0.29 10.9 0.2 1.2 1 0 0 1 1 1 0 TrbL/VirB6 plasmid conjugal transfer protein WD40 PF00400.32 ETO35018.1 - 2.8e-41 138.7 23.0 2.8e-07 31.1 0.4 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35018.1 - 6.1e-18 64.9 0.1 0.00066 19.9 0.0 6.4 5 1 1 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35018.1 - 2.9e-17 62.5 3.4 0.00018 20.3 0.0 5.4 1 1 4 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35018.1 - 4.2e-05 23.0 0.7 0.33 10.2 0.0 4.4 2 2 2 4 4 4 2 WD40-like domain SH3_13 PF18335.1 ETO35018.1 - 8.2e-05 22.4 3.7 0.078 12.8 0.0 3.7 4 0 0 4 4 4 1 ATP-dependent RecD-like DNA helicase SH3 domain DUF851 PF05867.11 ETO35018.1 - 0.0042 16.6 0.1 4.6 6.6 0.0 3.3 2 1 2 4 4 4 2 Protein of unknown function (DUF851) PQQ_3 PF13570.6 ETO35018.1 - 0.039 14.5 0.4 61 4.3 0.0 4.6 5 0 0 5 5 5 0 PQQ-like domain DUF5060 PF16586.5 ETO35018.1 - 0.19 12.1 1.1 52 4.3 0.0 4.0 4 1 0 4 4 4 0 Domain of unknown function (DUF5060) 3Beta_HSD PF01073.19 ETO35019.1 - 0.028 13.5 0.7 0.045 12.7 0.7 1.2 1 0 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family LAP1C PF05609.12 ETO35019.1 - 0.11 11.6 12.1 0.17 10.9 12.1 1.3 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Enolase_C PF00113.22 ETO35021.1 - 3.2e-08 33.2 0.4 3.8e-08 32.9 0.4 1.1 1 0 0 1 1 1 1 Enolase, C-terminal TIM barrel domain GIDA PF01134.22 ETO35021.1 - 0.024 13.7 0.2 0.04 13.0 0.2 1.3 1 0 0 1 1 1 0 Glucose inhibited division protein A Enolase_N PF03952.16 ETO35022.1 - 0.07 13.3 0.5 0.07 13.3 0.5 2.0 2 1 0 2 2 2 0 Enolase, N-terminal domain DUF2353 PF09789.9 ETO35023.1 - 0.00077 18.9 23.4 0.00077 18.9 23.4 3.2 2 2 1 3 3 3 1 Uncharacterized coiled-coil protein (DUF2353) PASTA PF03793.19 ETO35023.1 - 0.021 14.7 1.1 0.35 10.8 0.2 3.0 2 1 0 2 2 2 0 PASTA domain Shugoshin_N PF07558.11 ETO35023.1 - 0.15 12.0 4.4 3.9 7.4 0.9 3.2 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region ACP_PD PF04336.12 ETO35023.1 - 0.41 11.1 5.7 0.21 12.0 0.5 2.9 2 1 0 2 2 2 0 Acyl carrier protein phosphodiesterase FAA_hydro_N_2 PF18288.1 ETO35023.1 - 3.3 8.2 7.4 0.98 9.9 1.9 2.8 2 1 1 3 3 3 0 Fumarylacetoacetase N-terminal domain 2 MCC-bdg_PDZ PF10506.9 ETO35023.1 - 4.3 7.4 12.4 0.18 11.8 2.0 3.8 2 2 1 3 3 3 0 PDZ domain of MCC-2 bdg protein for Usher syndrome DUF812 PF05667.11 ETO35023.1 - 4.5 6.0 46.1 7.9 5.2 19.1 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF812) Ribonuc_red_sm PF00268.21 ETO35024.1 - 0.042 13.3 5.3 0.043 13.3 4.4 1.4 1 1 0 1 1 1 0 Ribonucleotide reductase, small chain DNA_topoisoIV PF00521.20 ETO35024.1 - 0.5 9.2 6.8 0.53 9.1 6.8 1.0 1 0 0 1 1 1 0 DNA gyrase/topoisomerase IV, subunit A Nop53 PF07767.11 ETO35025.1 - 4.5 6.6 22.0 4.8 6.5 22.0 1.1 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) TPR_12 PF13424.6 ETO35027.1 - 1.6e-95 313.5 12.4 1.2e-20 73.5 0.2 6.7 1 1 4 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35027.1 - 5.7e-72 235.9 0.0 1e-10 41.1 0.0 9.1 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35027.1 - 1.7e-57 189.0 50.5 3.5e-10 39.3 2.3 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35027.1 - 4.2e-57 186.1 0.4 7.8e-08 31.8 0.0 8.7 9 0 0 9 9 8 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35027.1 - 1.4e-47 156.0 51.2 2.2e-09 36.8 2.4 9.7 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35027.1 - 1.9e-43 143.0 30.8 3.1e-07 30.0 0.6 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35027.1 - 1.2e-26 91.2 16.6 0.00064 19.9 0.0 9.0 8 0 0 8 8 8 5 Tetratricopeptide repeat TPR_16 PF13432.6 ETO35027.1 - 1.1e-22 80.4 0.0 0.0076 16.9 0.0 8.2 5 2 4 9 9 8 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO35027.1 - 4.9e-15 54.9 0.0 0.17 12.8 0.0 8.6 5 1 3 8 8 8 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35027.1 - 9.5e-13 47.6 46.2 0.0015 18.2 2.6 10.1 7 3 4 11 11 10 5 TPR repeat TPR_3 PF07720.12 ETO35027.1 - 9.9e-12 44.6 22.5 0.21 11.6 0.6 7.8 7 0 0 7 7 7 5 Tetratricopeptide repeat SNAP PF14938.6 ETO35027.1 - 2.1e-11 43.8 12.6 6.3e-05 22.5 0.0 4.6 2 2 1 4 4 4 2 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO35027.1 - 4.2e-11 42.7 12.2 0.45 11.2 0.1 8.3 9 0 0 9 9 8 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO35027.1 - 5.4e-11 42.4 0.0 8.9e-07 28.6 0.0 2.9 1 1 2 3 3 3 3 MalT-like TPR region DUF5113 PF17140.4 ETO35027.1 - 1.6e-10 41.0 24.5 0.53 10.1 0.1 7.9 6 1 1 7 7 7 5 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO35027.1 - 7.5e-09 36.0 1.1 0.045 14.3 0.0 5.5 4 2 2 6 6 6 1 Tetratricopeptide repeat PPR PF01535.20 ETO35027.1 - 6.2e-07 29.2 20.1 0.16 12.2 0.1 8.8 10 0 0 10 10 8 2 PPR repeat TPR_21 PF09976.9 ETO35027.1 - 2.2e-05 24.2 4.6 0.00076 19.2 0.2 3.5 2 1 0 3 3 3 1 Tetratricopeptide repeat-like domain OrfA PF17495.2 ETO35027.1 - 0.00025 21.2 0.2 31 4.8 0.0 5.7 2 1 5 7 7 7 0 Vpr-like OrfA SPO22 PF08631.10 ETO35027.1 - 0.00025 20.6 3.1 0.65 9.4 1.2 3.3 3 0 0 3 3 3 2 Meiosis protein SPO22/ZIP4 like MIT PF04212.18 ETO35027.1 - 0.00038 20.5 33.8 0.33 11.0 0.8 8.8 9 0 0 9 9 9 1 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO35027.1 - 0.0031 16.9 1.4 14 5.2 0.0 5.5 7 0 0 7 7 6 0 SHNi-TPR Peptidase_C14 PF00656.22 ETO35027.1 - 0.0033 17.4 2.4 0.017 15.1 2.4 2.0 1 1 0 1 1 1 1 Caspase domain ANAPC3 PF12895.7 ETO35027.1 - 0.0072 16.5 20.1 0.22 11.8 4.6 5.9 2 2 4 6 6 6 2 Anaphase-promoting complex, cyclosome, subunit 3 MCM6_C PF18263.1 ETO35027.1 - 0.015 15.5 0.5 0.49 10.7 0.1 3.1 3 0 0 3 3 2 0 MCM6 C-terminal winged-helix domain DUF627 PF04781.12 ETO35027.1 - 0.03 14.3 10.5 6.7 6.8 0.0 5.5 4 1 1 5 5 5 0 Protein of unknown function (DUF627) RPN7 PF10602.9 ETO35027.1 - 0.046 13.4 19.2 12 5.5 0.1 6.7 2 2 2 6 6 6 0 26S proteasome subunit RPN7 DUF3856 PF12968.7 ETO35027.1 - 0.056 13.5 2.1 47 4.0 0.0 3.9 1 1 1 3 3 3 0 Domain of Unknown Function (DUF3856) HDV_ag PF01517.18 ETO35027.1 - 0.2 11.4 0.3 0.92 9.3 0.1 2.1 2 0 0 2 2 2 0 Hepatitis delta virus delta antigen Mob_Pre PF01076.19 ETO35027.1 - 0.94 9.3 11.0 0.87 9.4 0.7 4.0 3 1 1 4 4 4 0 Plasmid recombination enzyme DUF4810 PF16068.5 ETO35027.1 - 3.5 8.2 15.3 32 5.2 0.0 6.1 4 2 4 8 8 7 0 Domain of unknown function (DUF4810) Pep3_Vps18 PF05131.14 ETO35027.1 - 5.9 6.7 9.8 7.2 6.4 0.3 4.6 4 1 1 5 5 4 0 Pep3/Vps18/deep orange family HTH_Bact PF18768.1 ETO35027.1 - 7.1 6.3 12.2 26 4.5 0.2 5.3 5 1 0 5 5 4 0 Helix-turn-helix bacterial domain WD40 PF00400.32 ETO35028.1 - 4.8e-13 49.3 0.7 7.5e-05 23.4 0.0 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35028.1 - 0.0016 18.7 0.1 2.2 8.6 0.1 2.6 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain CagE_TrbE_VirB PF03135.14 ETO35030.1 - 0.088 12.9 0.0 0.093 12.8 0.0 1.1 1 0 0 1 1 1 0 CagE, TrbE, VirB family, component of type IV transporter system Capsid_NCLDV PF04451.12 ETO35031.1 - 0.23 11.3 1.3 3 7.6 0.1 2.1 2 0 0 2 2 2 0 Large eukaryotic DNA virus major capsid protein Spt20 PF12090.8 ETO35033.1 - 0.00017 21.3 0.4 0.00021 21.0 0.4 1.1 1 0 0 1 1 1 1 Spt20 family TPR_MalT PF17874.1 ETO35033.1 - 0.00033 20.1 0.3 0.018 14.4 0.1 2.1 2 0 0 2 2 2 1 MalT-like TPR region PBP1_TM PF14812.6 ETO35033.1 - 0.0011 19.3 0.3 0.0011 19.3 0.3 1.9 2 0 0 2 2 2 1 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO35033.1 - 0.028 13.8 2.6 0.03 13.6 2.6 1.1 1 0 0 1 1 1 0 NOA36 protein Colicin_immun PF09204.10 ETO35033.1 - 0.035 14.6 0.7 0.064 13.8 0.7 1.5 1 0 0 1 1 1 0 Bacterial self-protective colicin-like immunity FAM176 PF14851.6 ETO35033.1 - 0.081 12.6 0.4 0.13 12.0 0.4 1.3 1 0 0 1 1 1 0 FAM176 family DUF4611 PF15387.6 ETO35033.1 - 0.19 12.0 4.8 0.38 11.0 4.8 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sporozoite_P67 PF05642.11 ETO35033.1 - 0.69 7.9 4.8 0.84 7.6 4.8 1.0 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Orf78 PF06024.12 ETO35034.1 - 0.15 12.4 11.6 0.053 13.8 2.7 3.2 2 1 1 3 3 3 0 Orf78 (ac78) ER_lumen_recept PF00810.18 ETO35034.1 - 1.6 9.6 6.4 6.8 7.5 0.6 2.5 2 0 0 2 2 2 0 ER lumen protein retaining receptor MADF_DNA_bdg PF10545.9 ETO35035.1 - 0.13 12.6 0.1 1.2 9.5 0.1 2.0 2 0 0 2 2 2 0 Alcohol dehydrogenase transcription factor Myb/SANT-like PARP PF00644.20 ETO35036.1 - 8.7e-13 48.3 1.1 2.1e-12 47.0 1.1 1.7 1 1 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Exotox-A_cataly PF09009.10 ETO35036.1 - 0.05 13.3 0.1 2 8.1 0.1 2.7 3 0 0 3 3 3 0 Exotoxin A catalytic EVE PF01878.18 ETO35037.1 - 0.0017 18.4 0.0 0.0069 16.4 0.0 2.2 1 1 0 1 1 1 1 EVE domain Gly-zipper_YMGG PF13441.6 ETO35039.1 - 0.013 15.2 11.9 0.036 13.8 11.9 1.8 1 0 0 1 1 1 0 YMGG-like Gly-zipper Gly-zipper_OmpA PF13436.6 ETO35039.1 - 0.025 14.4 11.0 0.064 13.1 11.0 1.6 1 0 0 1 1 1 0 Glycine-zipper domain DUF456 PF04306.13 ETO35039.1 - 0.087 13.1 3.3 0.16 12.3 3.3 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF456) NSP2_assoc PF14758.6 ETO35039.1 - 0.097 13.0 0.0 0.22 11.8 0.0 1.6 1 0 0 1 1 1 0 Non-essential region of nsp2 of arterivirus polyprotein Bacteriocin_IIc PF10439.9 ETO35039.1 - 0.29 11.3 14.3 0.72 10.0 14.3 1.7 1 0 0 1 1 1 0 Bacteriocin class II with double-glycine leader peptide Rick_17kDa_Anti PF05433.15 ETO35039.1 - 0.66 9.9 15.4 1.4 8.9 5.3 2.0 1 1 1 2 2 2 0 Glycine zipper 2TM domain Gly-zipper_Omp PF13488.6 ETO35039.1 - 9.4 6.3 19.7 51 4.0 19.3 2.4 1 1 0 1 1 1 0 Glycine zipper WD40 PF00400.32 ETO35040.1 - 5.1e-16 58.8 17.7 1.2e-06 29.1 0.4 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35040.1 - 1.1e-05 25.6 0.5 0.045 14.1 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35040.1 - 3.5e-05 22.6 2.8 0.04 12.6 0.4 2.4 1 1 0 2 2 2 2 Nucleoporin Nup120/160 Transketolase_C PF02780.20 ETO35041.1 - 2.7e-40 137.1 0.0 6.1e-40 136.0 0.0 1.5 2 0 0 2 2 2 1 Transketolase, C-terminal domain WD40 PF00400.32 ETO35042.1 - 5.9e-13 49.1 5.7 8e-06 26.5 0.9 2.7 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35042.1 - 0.0059 16.9 0.7 0.052 13.9 0.0 2.9 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain zf-BED PF02892.15 ETO35042.1 - 0.15 12.1 6.5 0.5 10.4 0.4 3.8 3 0 0 3 3 3 0 BED zinc finger zf-C3HC4_3 PF13920.6 ETO35042.1 - 0.35 10.8 3.1 1.9 8.4 3.1 2.3 1 1 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) YscO-like PF16789.5 ETO35042.1 - 0.41 10.7 25.1 0.079 13.0 12.0 3.1 2 1 1 3 3 3 0 YscO-like protein SRP19 PF01922.17 ETO35043.1 - 0.17 12.8 0.0 0.22 12.5 0.0 1.1 1 0 0 1 1 1 0 SRP19 protein WD40 PF00400.32 ETO35044.1 - 6.6e-31 105.9 29.2 2.4e-06 28.2 1.7 6.4 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35044.1 - 2e-11 44.0 1.6 0.023 15.0 0.0 4.2 4 0 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35044.1 - 2.4e-07 29.8 3.3 0.028 13.1 0.0 3.7 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35044.1 - 6.3e-05 22.5 5.1 0.042 13.2 0.5 3.9 2 2 0 3 3 3 3 WD40-like domain WD40 PF00400.32 ETO35045.1 - 9e-20 70.7 2.8 4.1e-07 30.6 0.0 3.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35045.1 - 5.2e-11 42.7 0.5 0.0055 17.0 0.0 3.9 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35045.1 - 2.6e-08 33.5 0.9 0.00046 19.6 0.5 2.1 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETO35045.1 - 2.4e-07 30.0 0.1 0.0014 17.7 0.0 2.9 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO35045.1 - 0.022 13.4 0.4 0.21 10.2 0.4 2.4 1 1 0 1 1 1 0 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO35045.1 - 0.034 14.2 0.1 0.55 10.3 0.0 2.7 1 1 2 3 3 3 0 Ciliary BBSome complex subunit 2, middle region VID27 PF08553.10 ETO35045.1 - 0.055 12.5 0.1 0.59 9.1 0.0 1.9 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain PQQ_2 PF13360.6 ETO35045.1 - 0.073 12.6 0.0 0.17 11.4 0.0 1.6 1 1 1 2 2 2 0 PQQ-like domain RsgA_GTPase PF03193.16 ETO35046.1 - 6.7e-06 26.1 2.7 7.1e-05 22.8 0.0 2.5 3 0 0 3 3 2 1 RsgA GTPase PPV_E1_C PF00519.17 ETO35046.1 - 5.6e-05 22.2 0.3 0.21 10.4 0.0 2.2 2 0 0 2 2 2 2 Papillomavirus helicase DUF815 PF05673.13 ETO35046.1 - 0.00011 21.5 0.1 0.00024 20.3 0.1 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF815) MMR_HSR1 PF01926.23 ETO35046.1 - 0.00038 20.5 3.6 0.0015 18.6 0.7 2.9 2 1 0 2 2 2 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO35046.1 - 0.0042 17.6 0.0 0.0042 17.6 0.0 2.3 2 1 0 2 2 1 1 ABC transporter RNA_helicase PF00910.22 ETO35046.1 - 0.011 16.1 0.2 0.011 16.1 0.2 2.8 2 2 1 3 3 3 0 RNA helicase AAA_PrkA PF08298.11 ETO35046.1 - 0.011 14.6 0.0 0.021 13.8 0.0 1.4 1 1 0 1 1 1 0 PrkA AAA domain HNOBA PF07701.14 ETO35046.1 - 0.012 15.1 0.6 0.017 14.5 0.6 1.3 1 0 0 1 1 1 0 Heme NO binding associated PhoH PF02562.16 ETO35046.1 - 0.015 14.7 0.1 0.027 13.9 0.1 1.4 1 0 0 1 1 1 0 PhoH-like protein T2SSE PF00437.20 ETO35046.1 - 0.032 13.3 0.0 0.042 12.9 0.0 1.2 1 0 0 1 1 1 0 Type II/IV secretion system protein CoA_trans PF01144.23 ETO35046.1 - 0.039 13.4 0.0 0.056 12.8 0.0 1.3 1 0 0 1 1 1 0 Coenzyme A transferase AAA_19 PF13245.6 ETO35046.1 - 0.039 14.3 0.1 0.078 13.3 0.1 1.6 1 0 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETO35046.1 - 0.042 13.6 0.0 0.091 12.5 0.0 1.5 1 0 0 1 1 1 0 IstB-like ATP binding protein AAA_7 PF12775.7 ETO35046.1 - 0.051 13.1 0.0 0.11 12.0 0.0 1.5 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_28 PF13521.6 ETO35046.1 - 0.052 13.8 0.1 0.14 12.4 0.0 1.8 2 0 0 2 2 1 0 AAA domain FAM176 PF14851.6 ETO35046.1 - 0.06 13.0 6.5 0.15 11.7 6.5 1.7 1 0 0 1 1 1 0 FAM176 family Sporozoite_P67 PF05642.11 ETO35046.1 - 0.068 11.2 4.6 0.082 11.0 4.6 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen AAA_29 PF13555.6 ETO35046.1 - 0.072 12.8 0.0 0.15 11.9 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain LRAT PF04970.13 ETO35046.1 - 0.22 11.8 1.6 0.58 10.5 1.1 2.0 2 0 0 2 2 2 0 Lecithin retinol acyltransferase DNA_pol_phi PF04931.13 ETO35046.1 - 2.5 6.1 20.3 3.6 5.6 20.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi U1snRNP70_N PF12220.8 ETO35046.1 - 5.7 7.7 10.5 20 5.9 10.5 2.0 1 1 0 1 1 1 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal DUF2076 PF09849.9 ETO35046.1 - 5.8 6.9 12.1 8.9 6.3 12.1 1.3 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Dynamin_N PF00350.23 ETO35046.1 - 5.9 6.9 13.5 11 6.1 0.4 3.5 3 1 1 4 4 4 0 Dynamin family RsgA_GTPase PF03193.16 ETO35047.1 - 6.6e-05 22.9 4.8 0.00014 21.8 0.7 3.6 2 2 1 3 3 3 1 RsgA GTPase MMR_HSR1 PF01926.23 ETO35047.1 - 9.1e-05 22.5 0.1 0.00087 19.4 0.1 2.9 1 0 0 1 1 1 1 50S ribosome-binding GTPase ABC_tran PF00005.27 ETO35047.1 - 0.00013 22.5 0.1 0.00013 22.5 0.1 4.3 4 1 0 4 4 4 1 ABC transporter AAA_19 PF13245.6 ETO35047.1 - 0.01 16.2 0.2 0.042 14.2 0.2 2.3 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETO35047.1 - 0.051 13.3 0.1 0.17 11.6 0.1 1.9 1 0 0 1 1 1 0 IstB-like ATP binding protein Zeta_toxin PF06414.12 ETO35047.1 - 0.08 12.2 3.7 0.085 12.1 0.1 2.9 3 1 1 4 4 4 0 Zeta toxin RNA_helicase PF00910.22 ETO35047.1 - 0.083 13.3 1.5 1.6 9.1 0.0 3.8 4 0 0 4 4 4 0 RNA helicase AAA_29 PF13555.6 ETO35047.1 - 0.14 11.9 0.0 0.32 10.8 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sec20 PF03908.13 ETO35047.1 - 0.52 10.3 2.9 7.9 6.5 0.2 4.3 2 1 0 2 2 2 0 Sec20 Ank_2 PF12796.7 ETO35048.1 - 0.00016 22.2 1.1 0.00036 21.1 0.7 1.5 1 1 0 1 1 1 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO35048.1 - 0.096 13.3 1.1 0.4 11.4 0.1 2.4 3 0 0 3 3 3 0 Ankyrin repeat Kelch_1 PF01344.25 ETO35050.1 - 2.2e-07 30.4 1.2 0.00092 18.7 0.1 3.7 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO35050.1 - 1.1e-05 25.2 4.8 0.0065 16.4 0.2 4.2 4 1 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO35050.1 - 7.6e-05 22.9 3.7 0.81 10.1 0.1 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO35050.1 - 0.0019 18.5 0.2 0.48 10.8 0.0 4.1 5 0 0 5 5 5 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35050.1 - 0.0074 16.3 6.3 0.23 11.5 0.2 4.2 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO35050.1 - 0.017 15.2 2.5 0.088 12.8 0.1 2.7 2 1 1 3 3 3 0 Galactose oxidase, central domain Imm2 PF14426.6 ETO35053.1 - 0.17 12.0 0.3 0.33 11.0 0.3 1.5 1 0 0 1 1 1 0 Immunity protein Imm2 WD40 PF00400.32 ETO35054.1 - 4.9e-14 52.5 2.2 3.5e-08 34.0 0.0 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat Morc6_S5 PF17942.1 ETO35054.1 - 0.01 15.9 1.9 0.017 15.2 1.7 1.5 1 1 0 1 1 1 0 Morc6 ribosomal protein S5 domain 2-like WD40 PF00400.32 ETO35055.1 - 1.1e-35 121.0 19.1 4.1e-05 24.2 0.5 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO35055.1 - 4.9e-10 38.7 5.7 0.12 11.0 0.1 4.6 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35055.1 - 1.1e-09 38.4 1.0 0.14 12.4 0.1 5.7 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain zf-TRAF PF02176.18 ETO35055.1 - 0.0003 21.4 2.3 0.0003 21.4 2.3 2.4 2 0 0 2 2 2 1 TRAF-type zinc finger Tau95 PF09734.9 ETO35055.1 - 1.4 9.8 4.8 1.9 9.3 3.9 1.7 2 0 0 2 2 2 0 RNA polymerase III transcription factor (TF)IIIC subunit HTH domain OAD_gamma PF04277.13 ETO35055.1 - 1.8 9.2 4.6 19 5.9 0.2 2.5 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain Speriolin_C PF15059.6 ETO35057.1 - 0.03 14.4 0.0 0.084 13.0 0.0 1.7 2 0 0 2 2 2 0 Speriolin C-terminus WD40 PF00400.32 ETO35058.1 - 9e-41 137.1 14.3 7.4e-08 32.9 0.0 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35058.1 - 5.1e-10 39.5 2.7 0.6 10.5 0.1 5.1 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35058.1 - 5.5e-09 35.4 0.1 0.00054 19.0 0.0 3.3 2 1 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO35058.1 - 1.2e-07 30.8 8.8 0.74 8.4 0.0 5.8 4 2 2 6 6 6 5 Nucleoporin Nup120/160 SGL PF08450.12 ETO35058.1 - 0.017 14.7 0.4 0.79 9.2 0.1 2.6 2 1 0 2 2 2 0 SMP-30/Gluconolactonase/LRE-like region DUF5570 PF17731.1 ETO35058.1 - 0.046 13.8 1.7 22 5.1 0.0 3.9 2 1 2 4 4 4 0 Family of unknown function (DUF5570) Pkinase PF00069.25 ETO35060.1 - 2.4e-60 204.1 0.0 3.6e-60 203.6 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35060.1 - 4.1e-22 78.7 0.1 8.2e-22 77.7 0.1 1.4 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase_fungal PF17667.1 ETO35060.1 - 4.3e-06 25.8 0.0 7.4e-06 25.0 0.0 1.2 1 0 0 1 1 1 1 Fungal protein kinase Kinase-like PF14531.6 ETO35060.1 - 0.024 13.9 0.2 0.038 13.3 0.2 1.2 1 0 0 1 1 1 0 Kinase-like APH PF01636.23 ETO35060.1 - 0.047 13.6 0.0 0.089 12.7 0.0 1.5 1 0 0 1 1 1 0 Phosphotransferase enzyme family DUF2538 PF10804.8 ETO35060.1 - 0.3 10.8 2.3 4.6 7.0 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF2538) p450 PF00067.22 ETO35061.1 - 6.1e-31 107.7 13.5 1e-15 57.4 0.4 3.0 2 1 0 2 2 2 2 Cytochrome P450 DUF1870 PF08965.10 ETO35061.1 - 0.025 14.6 0.4 1.6 8.8 0.0 3.2 3 0 0 3 3 3 0 Domain of unknown function (DUF1870) Noggin PF05806.12 ETO35061.1 - 0.54 10.2 1.8 3.8 7.4 0.9 2.6 2 1 0 2 2 2 0 Noggin WD40 PF00400.32 ETO35062.1 - 5.6e-15 55.5 11.7 0.0007 20.4 2.1 4.6 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35062.1 - 1.9e-07 31.3 0.1 0.062 13.6 0.0 3.0 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35062.1 - 1.2e-05 24.2 0.6 0.26 9.9 0.0 3.0 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35062.1 - 0.0081 15.5 1.3 0.32 10.3 0.1 2.7 1 1 2 3 3 3 1 WD40-like domain HARP PF07443.13 ETO35062.1 - 0.026 14.2 0.0 2.5 7.8 0.0 2.5 2 0 0 2 2 2 0 HepA-related protein (HARP) SprA-related PF12118.8 ETO35063.1 - 0.0049 16.1 22.2 0.012 14.7 22.2 1.7 1 0 0 1 1 1 1 SprA-related family CPSF100_C PF13299.6 ETO35063.1 - 0.0054 16.9 5.6 0.0054 16.9 5.6 2.4 3 0 0 3 3 3 1 Cleavage and polyadenylation factor 2 C-terminal SpoIIP PF07454.11 ETO35063.1 - 0.0073 15.8 7.7 0.0073 15.8 7.7 2.2 3 0 0 3 3 3 1 Stage II sporulation protein P (SpoIIP) Activator_LAG-3 PF11498.8 ETO35063.1 - 0.0083 15.1 41.2 0.014 14.4 41.2 1.3 1 0 0 1 1 1 1 Transcriptional activator LAG-3 Serinc PF03348.15 ETO35063.1 - 0.052 12.5 2.1 0.085 11.8 2.1 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) TFIIA PF03153.13 ETO35063.1 - 0.27 11.2 50.5 0.52 10.3 50.5 1.6 1 1 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit CLN3 PF02487.17 ETO35063.1 - 0.31 10.1 6.1 0.6 9.1 6.1 1.4 1 0 0 1 1 1 0 CLN3 protein SID-1_RNA_chan PF13965.6 ETO35063.1 - 0.43 8.9 1.5 0.62 8.4 1.5 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4407 PF14362.6 ETO35063.1 - 0.45 9.8 12.0 0.8 9.0 12.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) FHIPEP PF00771.20 ETO35063.1 - 0.53 8.7 3.5 0.71 8.3 3.5 1.1 1 0 0 1 1 1 0 FHIPEP family Peptidase_U57 PF05582.12 ETO35063.1 - 0.83 8.9 5.8 1.7 7.8 5.8 1.4 1 0 0 1 1 1 0 YabG peptidase U57 Membralin PF09746.9 ETO35063.1 - 1.1 8.2 4.7 1.8 7.5 4.7 1.3 1 0 0 1 1 1 0 Tumour-associated protein DUF1980 PF09323.10 ETO35063.1 - 2.5 8.0 7.2 5.7 6.8 7.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1980) LMBR1 PF04791.16 ETO35063.1 - 5.6 5.8 5.5 7.8 5.3 5.5 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein Het-C PF07217.11 ETO35063.1 - 5.7 5.3 7.5 8.2 4.8 7.5 1.1 1 0 0 1 1 1 0 Heterokaryon incompatibility protein Het-C MecA PF05389.12 ETO35063.1 - 6.8 6.3 12.3 0.19 11.4 5.2 1.9 2 0 0 2 2 2 0 Negative regulator of genetic competence (MecA) SpaA PF17802.1 ETO35064.1 - 0.099 13.0 3.0 0.13 12.6 0.1 2.7 4 0 0 4 4 4 0 Prealbumin-like fold domain Cdh1_DBD_1 PF18196.1 ETO35066.1 - 0.79 10.0 4.5 0.85 9.9 3.0 1.8 1 1 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 DUF423 PF04241.15 ETO35067.1 - 0.78 10.0 5.1 0.36 11.0 1.6 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF423) DUF3328 PF11807.8 ETO35067.1 - 2.5 7.8 4.1 0.62 9.8 0.8 1.6 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) E3_UbLigase_R4 PF13764.6 ETO35068.1 - 3.9e-74 250.3 5.1 4.6e-72 243.4 5.1 2.5 1 1 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 FAM167 PF11652.8 ETO35068.1 - 0.06 13.8 3.7 0.074 13.5 1.1 2.5 3 0 0 3 3 3 0 FAM167 DZR PF12773.7 ETO35068.1 - 0.11 12.6 3.0 13 5.9 0.2 3.5 2 1 1 3 3 3 0 Double zinc ribbon E3_UbLigase_R4 PF13764.6 ETO35069.1 - 1e-45 156.3 4.3 2.5e-45 155.0 4.3 1.6 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 RICTOR_M PF14666.6 ETO35069.1 - 0.037 13.8 4.8 1.7 8.5 0.0 3.4 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR, middle domain ANAPC15 PF15243.6 ETO35069.1 - 0.17 12.3 2.7 0.6 10.5 2.7 2.0 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 DUF1840 PF08895.11 ETO35069.1 - 0.65 10.3 4.2 23 5.4 5.1 2.7 2 0 0 2 2 2 0 Domain of unknown function (DUF1840) Chorion_2 PF03964.15 ETO35069.1 - 1.4 9.8 8.4 0.62 10.9 3.2 2.5 2 0 0 2 2 2 0 Chorion family 2 FAM199X PF15814.5 ETO35069.1 - 8.4 5.4 12.1 0.41 9.7 6.1 1.8 2 0 0 2 2 2 0 Protein family FAM199X PEN-2 PF10251.9 ETO35073.1 - 0.062 13.7 1.0 0.062 13.7 1.0 1.8 1 1 1 2 2 2 0 Presenilin enhancer-2 subunit of gamma secretase Snf7 PF03357.21 ETO35074.1 - 6.1e-25 87.8 32.6 6.9e-22 77.9 14.0 2.2 1 1 1 2 2 2 2 Snf7 Laminin_II PF06009.12 ETO35074.1 - 0.0021 18.1 7.1 0.043 13.8 0.8 2.3 2 0 0 2 2 2 2 Laminin Domain II Citrate_ly_lig PF08218.11 ETO35074.1 - 0.0021 17.7 0.7 0.01 15.5 0.0 2.3 2 1 1 3 3 3 1 Citrate lyase ligase C-terminal domain DUF948 PF06103.11 ETO35074.1 - 0.059 13.6 6.2 1.1 9.5 0.7 2.4 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF948) DUF4407 PF14362.6 ETO35074.1 - 0.081 12.3 6.3 0.11 11.8 6.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) NPV_P10 PF05531.12 ETO35074.1 - 0.15 12.6 7.0 1.8 9.1 1.4 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FlaC_arch PF05377.11 ETO35074.1 - 0.35 11.3 7.3 9.4 6.7 1.4 3.6 3 1 1 4 4 4 0 Flagella accessory protein C (FlaC) Halogen_Hydrol PF10112.9 ETO35074.1 - 0.7 9.9 9.2 0.13 12.2 1.5 2.2 2 0 0 2 2 2 0 5-bromo-4-chloroindolyl phosphate hydrolysis protein FlxA PF14282.6 ETO35074.1 - 1 9.4 11.4 0.46 10.5 4.1 2.5 2 0 0 2 2 2 0 FlxA-like protein COG5 PF10392.9 ETO35074.1 - 1.2 9.3 6.2 2.6 8.2 0.4 2.3 2 0 0 2 2 2 0 Golgi transport complex subunit 5 YabA PF06156.13 ETO35074.1 - 3.5 8.3 7.6 11 6.8 0.3 2.7 2 1 0 2 2 2 0 Initiation control protein YabA Nup88 PF10168.9 ETO35074.1 - 4.1 5.1 14.6 0.19 9.5 6.0 2.0 1 1 1 2 2 2 0 Nuclear pore component PIEZO PF15917.5 ETO35074.1 - 7.9 5.9 11.2 2.1 7.8 4.5 2.2 2 0 0 2 2 2 0 Piezo Prefoldin_2 PF01920.20 ETO35074.1 - 9.3 6.3 18.1 2 8.4 6.5 3.3 2 1 1 3 3 3 0 Prefoldin subunit DUF4467 PF14729.6 ETO35075.1 - 0.34 11.3 9.7 2.2 8.7 4.6 2.5 1 1 1 2 2 2 0 Domain of unknown function with cystatin-like fold (DUF4467) ELMO_CED12 PF04727.13 ETO35076.1 - 6e-06 26.5 1.3 1.1e-05 25.6 0.2 2.0 2 0 0 2 2 2 1 ELMO/CED-12 family DUF1754 PF08555.10 ETO35076.1 - 0.012 16.4 6.5 0.012 16.4 6.5 2.0 2 1 0 2 2 2 0 Eukaryotic family of unknown function (DUF1754) Rib_recp_KP_reg PF05104.12 ETO35076.1 - 2.8 9.0 14.0 4.5 8.3 14.0 1.3 1 0 0 1 1 1 0 Ribosome receptor lysine/proline rich region Rtf2 PF04641.12 ETO35076.1 - 6 6.2 9.6 0.74 9.1 4.9 1.8 2 0 0 2 2 2 0 Rtf2 RING-finger Kelch_1 PF01344.25 ETO35077.1 - 3e-06 26.7 0.9 0.053 13.1 0.4 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_6 PF13964.6 ETO35077.1 - 1.1e-05 25.6 0.9 0.8 10.1 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO35077.1 - 0.0013 18.7 4.4 2.1 8.4 0.0 4.3 4 1 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO35077.1 - 1.4 9.0 8.0 7.6 6.6 0.7 3.6 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO35078.1 - 1.5e-16 60.5 5.2 1.9e-09 38.0 0.5 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35078.1 - 9.5e-06 24.5 0.4 0.011 14.4 0.0 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO35079.1 - 4e-07 30.6 11.3 2.9e-05 24.7 1.9 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 ETO35080.1 - 3.4e-17 62.5 3.9 1.8e-06 28.5 0.3 3.9 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35080.1 - 1.1e-06 27.7 0.7 0.32 9.6 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35080.1 - 6.9e-06 26.3 0.2 0.029 14.7 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35080.1 - 0.00062 19.2 0.5 0.026 13.9 0.0 2.0 1 1 0 2 2 2 2 WD40-like domain zf-SNAP50_C PF12251.8 ETO35081.1 - 2.6e-57 193.7 9.1 3.1e-57 193.5 9.1 1.0 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal zf-Dof PF02701.15 ETO35081.1 - 0.00026 21.1 5.2 0.00053 20.1 5.2 1.5 1 0 0 1 1 1 1 Dof domain, zinc finger DCAF15_WD40 PF14939.6 ETO35081.1 - 0.005 16.5 0.3 0.0061 16.2 0.3 1.1 1 0 0 1 1 1 1 DDB1-and CUL4-substrate receptor 15, WD repeat C2 PF00168.30 ETO35082.1 - 2.4e-22 79.2 0.0 4.8e-22 78.2 0.0 1.5 1 0 0 1 1 1 1 C2 domain FPP PF05911.11 ETO35082.1 - 0.00047 18.5 16.1 0.00059 18.2 16.1 1.1 1 0 0 1 1 1 1 Filament-like plant protein, long coiled-coil Spc7 PF08317.11 ETO35082.1 - 0.026 13.4 25.1 0.037 12.9 25.1 1.2 1 0 0 1 1 1 0 Spc7 kinetochore protein Golgin_A5 PF09787.9 ETO35082.1 - 0.027 13.9 21.9 0.041 13.4 21.9 1.2 1 0 0 1 1 1 0 Golgin subfamily A member 5 LptF_LptG PF03739.14 ETO35082.1 - 0.84 8.4 7.5 1.2 7.9 6.9 1.4 1 1 0 1 1 1 0 Lipopolysaccharide export system permease LptF/LptG HrpB7 PF09486.10 ETO35082.1 - 0.95 9.8 14.5 2.2 8.7 5.3 2.7 3 0 0 3 3 3 0 Bacterial type III secretion protein (HrpB7) DivIC PF04977.15 ETO35082.1 - 1.5 8.6 36.0 0.17 11.7 3.3 4.4 2 2 2 4 4 4 0 Septum formation initiator AAA_13 PF13166.6 ETO35082.1 - 1.5 7.3 21.2 2 6.9 21.2 1.1 1 0 0 1 1 1 0 AAA domain ADIP PF11559.8 ETO35082.1 - 1.7 8.7 29.8 1.9 8.6 8.8 2.3 2 0 0 2 2 2 0 Afadin- and alpha -actinin-Binding Exonuc_VII_L PF02601.15 ETO35082.1 - 9 5.8 14.4 14 5.2 14.4 1.3 1 0 0 1 1 1 0 Exonuclease VII, large subunit Gaa1 PF04114.14 ETO35083.1 - 9.1e-24 84.3 9.3 4.5e-23 82.0 9.3 2.1 1 1 0 1 1 1 1 Gaa1-like, GPI transamidase component PEN-2 PF10251.9 ETO35083.1 - 0.039 14.4 0.0 0.039 14.4 0.0 3.0 3 0 0 3 3 3 0 Presenilin enhancer-2 subunit of gamma secretase Ac76 PF05814.11 ETO35083.1 - 1.8 8.6 10.4 6.8 6.8 0.0 3.5 3 0 0 3 3 3 0 Orf76 (Ac76) YqzH PF14164.6 ETO35084.1 - 0.0084 16.2 0.4 0.033 14.3 0.4 2.0 1 0 0 1 1 1 1 YqzH-like protein Neur_chan_memb PF02932.16 ETO35084.1 - 6.4 6.7 7.5 8 6.4 7.5 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region SPRY PF00622.28 ETO35086.1 - 9.7e-05 22.5 0.0 0.00014 21.9 0.0 1.3 1 0 0 1 1 1 1 SPRY domain SAM_2 PF07647.17 ETO35088.1 - 0.009 16.1 0.3 0.02 15.0 0.3 1.6 1 1 0 1 1 1 1 SAM domain (Sterile alpha motif) TraA PF05513.11 ETO35088.1 - 0.02 15.2 0.0 0.034 14.5 0.0 1.4 1 1 1 2 2 2 0 TraA WD40 PF00400.32 ETO35090.1 - 1e-22 80.0 11.4 8.5e-09 35.9 0.1 6.5 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35090.1 - 1.8e-17 63.4 3.3 0.00045 20.5 0.1 5.4 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO35090.1 - 2.8e-07 30.6 1.1 0.012 15.5 0.0 3.1 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A AAA_22 PF13401.6 ETO35090.1 - 4.5e-05 23.8 0.0 0.00029 21.1 0.0 2.2 1 1 1 2 2 2 1 AAA domain SGL PF08450.12 ETO35090.1 - 0.00092 18.9 0.2 0.76 9.3 0.0 2.9 1 1 1 2 2 2 2 SMP-30/Gluconolactonase/LRE-like region WD40_like PF17005.5 ETO35090.1 - 0.0037 16.6 2.6 0.022 14.1 0.0 2.9 3 0 0 3 3 3 1 WD40-like domain ATPase_2 PF01637.18 ETO35090.1 - 0.0052 16.7 0.9 0.0052 16.7 0.9 2.7 2 1 0 2 2 2 1 ATPase domain predominantly from Archaea PduV-EutP PF10662.9 ETO35090.1 - 0.016 15.0 0.0 0.043 13.6 0.0 1.8 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation PD40 PF07676.12 ETO35090.1 - 0.02 14.8 0.0 21 5.2 0.0 3.6 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat TsaE PF02367.17 ETO35090.1 - 0.021 14.8 0.0 0.05 13.6 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE RNA_helicase PF00910.22 ETO35090.1 - 0.021 15.2 0.2 0.11 12.9 0.0 2.4 2 0 0 2 2 1 0 RNA helicase Kinesin PF00225.23 ETO35090.1 - 0.021 13.8 1.1 0.038 12.9 0.1 1.9 2 0 0 2 2 2 0 Kinesin motor domain ABC_tran PF00005.27 ETO35090.1 - 0.047 14.2 0.0 0.49 10.9 0.0 2.8 3 0 0 3 3 3 0 ABC transporter AAA_18 PF13238.6 ETO35090.1 - 0.061 13.9 0.1 0.29 11.7 0.0 2.3 2 0 0 2 2 2 0 AAA domain PQQ_2 PF13360.6 ETO35090.1 - 0.067 12.8 0.1 2.3 7.7 0.0 2.2 1 1 1 2 2 2 0 PQQ-like domain AAA_16 PF13191.6 ETO35090.1 - 0.18 12.2 0.0 1.8 8.9 0.0 2.4 2 0 0 2 2 2 0 AAA ATPase domain Roc PF08477.13 ETO35090.1 - 1.5 9.1 4.8 4.9 7.4 0.0 4.0 5 0 0 5 5 5 0 Ras of Complex, Roc, domain of DAPkinase TPR_12 PF13424.6 ETO35091.1 - 2.4e-19 69.4 4.6 1.5e-13 50.8 0.2 3.4 1 1 1 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35091.1 - 1.5e-12 47.0 4.0 2.4e-05 24.1 0.0 4.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35091.1 - 3.1e-10 39.4 6.7 0.00041 20.0 2.8 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35091.1 - 1.4e-09 37.3 1.1 0.00019 21.2 0.0 3.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35091.1 - 6.3e-06 25.9 2.7 0.0075 16.3 0.9 3.0 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35091.1 - 3.6e-05 23.6 13.7 0.0044 17.1 1.1 4.7 5 0 0 5 5 5 2 Tetratricopeptide repeat UPF0047 PF01894.17 ETO35091.1 - 0.08 13.1 0.5 0.28 11.3 0.5 2.0 1 0 0 1 1 1 0 Uncharacterised protein family UPF0047 TPR_11 PF13414.6 ETO35091.1 - 0.34 10.6 6.6 5.1 6.9 0.4 3.8 2 2 2 4 4 4 0 TPR repeat TPR_17 PF13431.6 ETO35091.1 - 0.71 10.4 4.3 2.5 8.7 0.2 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat Myotub-related PF06602.14 ETO35093.1 - 1e-73 248.3 1.4 1.2e-73 248.1 1.4 1.0 1 0 0 1 1 1 1 Myotubularin-like phosphatase domain Nop16 PF09420.10 ETO35094.1 - 1.8e-12 47.8 14.4 5.4e-12 46.2 14.4 1.9 1 1 0 1 1 1 1 Ribosome biogenesis protein Nop16 Pilus_CpaD PF09476.10 ETO35094.1 - 0.03 14.0 0.1 0.042 13.6 0.1 1.2 1 0 0 1 1 1 0 Pilus biogenesis CpaD protein (pilus_cpaD) Sec62 PF03839.16 ETO35094.1 - 0.053 13.0 5.9 0.079 12.5 5.9 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 UCH PF00443.29 ETO35095.1 - 1.1e-28 100.5 0.2 1.1e-28 100.5 0.2 2.5 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO35095.1 - 1.2e-17 64.5 0.1 1.2e-17 64.5 0.1 2.1 2 1 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase PapG_N PF03627.13 ETO35095.1 - 0.014 15.1 0.1 0.033 13.8 0.1 1.6 1 0 0 1 1 1 0 PapG carbohydrate binding domain Peptidase_C98 PF15499.6 ETO35095.1 - 0.018 14.5 3.8 0.15 11.5 0.1 3.0 2 1 1 3 3 3 0 Ubiquitin-specific peptidase-like, SUMO isopeptidase MAP17 PF15807.5 ETO35097.1 - 0.12 12.6 7.6 0.29 11.4 7.6 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Bromodomain PF00439.25 ETO35098.1 - 0.0017 18.4 0.1 0.0039 17.2 0.1 1.6 1 0 0 1 1 1 1 Bromodomain Kre28 PF17097.5 ETO35099.1 - 0.00032 19.8 3.5 0.00035 19.6 3.5 1.0 1 0 0 1 1 1 1 Spindle pole body component Relaxase PF03432.14 ETO35099.1 - 0.01 15.5 2.2 0.012 15.3 2.2 1.0 1 0 0 1 1 1 0 Relaxase/Mobilisation nuclease domain VTC PF09359.10 ETO35099.1 - 0.028 13.8 5.0 0.3 10.5 2.7 2.0 2 0 0 2 2 2 0 VTC domain SpoIISA_toxin PF14171.6 ETO35099.1 - 0.028 14.1 0.6 0.032 13.9 0.6 1.1 1 0 0 1 1 1 0 Toxin SpoIISA, type II toxin-antitoxin system Rsc14 PF08586.10 ETO35099.1 - 0.063 14.1 0.6 0.1 13.4 0.6 1.4 1 0 0 1 1 1 0 RSC complex, Rsc14/Ldb7 subunit RVT_1 PF00078.27 ETO35101.1 - 0.022 14.3 0.1 0.031 13.8 0.1 1.2 1 0 0 1 1 1 0 Reverse transcriptase (RNA-dependent DNA polymerase) LRR_4 PF12799.7 ETO35102.1 - 0.053 14.0 0.9 0.31 11.5 0.3 2.5 2 0 0 2 2 2 0 Leucine Rich repeats (2 copies) Ank_5 PF13857.6 ETO35103.1 - 0.00013 22.2 0.0 0.00057 20.1 0.0 2.0 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO35103.1 - 0.012 16.0 0.2 0.059 13.9 0.0 2.2 2 0 0 2 2 2 0 Ankyrin repeat Ank PF00023.30 ETO35103.1 - 0.11 13.0 0.0 0.44 11.1 0.0 2.0 1 0 0 1 1 1 0 Ankyrin repeat cNMP_binding PF00027.29 ETO35106.1 - 0.00019 21.4 0.0 0.00041 20.4 0.0 1.5 1 0 0 1 1 1 1 Cyclic nucleotide-binding domain DUF489 PF04356.12 ETO35106.1 - 3 7.8 9.0 0.4 10.7 4.2 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF489) WD40 PF00400.32 ETO35107.1 - 2.1e-34 117.0 28.9 5.8e-08 33.3 0.2 6.7 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35107.1 - 7.9e-10 38.9 2.0 0.63 10.4 0.0 4.8 3 2 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35107.1 - 3.1e-07 29.4 5.9 0.57 8.8 0.2 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 CENP-N PF05238.13 ETO35109.1 - 0.04 13.2 0.8 0.048 13.0 0.8 1.1 1 0 0 1 1 1 0 Kinetochore protein CHL4 like AsmA_2 PF13502.6 ETO35109.1 - 0.04 13.4 0.0 0.048 13.2 0.0 1.1 1 0 0 1 1 1 0 AsmA-like C-terminal region RelE PF06296.12 ETO35110.1 - 0.0019 18.3 2.1 0.35 11.0 0.3 3.3 2 0 0 2 2 2 2 RelE toxin of RelE / RelB toxin-antitoxin system MscS_TM PF12794.7 ETO35110.1 - 0.12 11.3 0.2 0.19 10.6 0.2 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 DUF2087 PF09860.9 ETO35110.1 - 0.19 11.9 2.6 1.6 8.9 0.2 3.0 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2087) DUF956 PF06115.11 ETO35110.1 - 0.19 11.4 8.5 0.44 10.3 0.2 4.0 3 0 0 3 3 3 0 Domain of unknown function (DUF956) Lipoprotein_15 PF03640.15 ETO35112.1 - 0.23 11.1 0.5 0.5 10.0 0.5 1.5 1 0 0 1 1 1 0 Secreted repeat of unknown function PH_BEACH PF14844.6 ETO35112.1 - 0.61 10.2 4.5 0.67 10.1 0.2 2.7 2 1 0 2 2 2 0 PH domain associated with Beige/BEACH WD40 PF00400.32 ETO35114.1 - 2.1e-28 98.0 11.2 8.4e-07 29.6 0.2 6.1 5 2 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35114.1 - 9.6e-08 32.2 0.3 0.46 10.8 0.0 4.1 3 1 0 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35114.1 - 0.00011 21.0 4.6 2.3 6.8 0.1 4.2 2 1 2 5 5 5 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO35114.1 - 0.0081 16.1 1.0 0.16 11.8 0.1 2.8 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A MIR PF02815.19 ETO35114.1 - 0.1 12.4 0.7 5.9 6.7 0.0 2.8 1 1 2 3 3 3 0 MIR domain WD40 PF00400.32 ETO35115.1 - 3.3e-25 87.9 11.9 4.9e-07 30.3 0.8 4.9 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35115.1 - 1.5e-08 34.8 0.1 0.066 13.5 0.0 3.6 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35115.1 - 3.3e-07 29.3 1.1 0.57 8.8 0.1 4.0 3 1 0 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35115.1 - 4.5e-05 22.9 3.3 0.15 11.4 0.1 3.7 2 1 2 4 4 4 3 WD40-like domain DUF383 PF04063.14 ETO35116.1 - 0.038 13.7 0.1 0.051 13.2 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF383) RICTOR_V PF14668.6 ETO35116.1 - 0.2 11.9 1.4 10 6.5 0.1 2.5 2 0 0 2 2 2 0 Rapamycin-insensitive companion of mTOR, domain 5 RPA_C PF08784.11 ETO35118.1 - 0.0014 19.3 0.2 0.0017 19.0 0.2 1.2 1 0 0 1 1 1 1 Replication protein A C terminal Proteasome PF00227.26 ETO35119.1 - 1.8e-15 56.9 0.0 5.2e-15 55.4 0.0 1.7 1 1 0 1 1 1 1 Proteasome subunit WD40 PF00400.32 ETO35120.1 - 1e-37 127.5 16.5 4.2e-06 27.4 0.1 7.0 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35120.1 - 1.3e-11 44.6 4.3 0.0015 18.8 0.0 5.8 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35120.1 - 8.7e-09 34.5 7.1 0.035 12.8 0.2 4.6 1 1 3 5 5 5 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO35120.1 - 0.007 16.4 6.3 2.4 8.2 1.1 4.4 2 1 2 4 4 4 2 Ciliary BBSome complex subunit 2, middle region DUF678 PF05077.12 ETO35120.1 - 2.4 8.4 5.4 32 4.7 0.1 3.7 4 0 0 4 4 4 0 Protein of unknown function (DUF678) WD40 PF00400.32 ETO35121.1 - 0.022 15.6 0.1 0.073 14.0 0.1 1.9 1 1 0 1 1 1 0 WD domain, G-beta repeat WD40 PF00400.32 ETO35122.1 - 1.4e-05 25.8 1.4 3.1 8.8 0.2 4.1 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35122.1 - 0.1 12.9 0.0 0.87 9.9 0.0 2.3 1 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO35123.1 - 9.2e-51 168.7 17.5 4.7e-09 36.7 0.1 8.7 8 0 0 8 8 8 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35123.1 - 2.3e-20 72.7 1.0 0.0056 16.9 0.0 6.7 2 1 5 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35123.1 - 2e-12 46.7 0.7 0.031 13.3 0.0 5.2 2 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO35123.1 - 1.3e-08 34.8 2.4 0.00083 19.6 0.3 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO35123.1 - 5.3e-07 29.6 0.2 8.2e-06 25.7 0.2 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Nup160 PF11715.8 ETO35123.1 - 5.8e-07 28.5 0.9 0.55 8.8 0.0 5.3 2 1 2 5 5 5 2 Nucleoporin Nup120/160 Kelch_2 PF07646.15 ETO35123.1 - 0.00021 21.1 3.2 0.014 15.4 0.4 4.8 5 0 0 5 5 5 1 Kelch motif Nbas_N PF15492.6 ETO35123.1 - 0.00096 18.6 0.6 0.026 13.9 0.0 3.3 4 1 1 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Kelch_1 PF01344.25 ETO35123.1 - 0.0015 18.1 0.5 0.027 14.1 0.6 2.9 3 0 0 3 3 3 1 Kelch motif Cytochrom_D1 PF02239.16 ETO35123.1 - 0.0019 16.8 0.1 0.55 8.7 0.0 2.5 2 0 0 2 2 2 2 Cytochrome D1 heme domain Kelch_5 PF13854.6 ETO35123.1 - 0.0024 17.8 1.7 18 5.4 0.4 4.1 4 0 0 4 4 4 0 Kelch motif PD40 PF07676.12 ETO35123.1 - 0.0055 16.6 8.9 5.8 7.0 0.1 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Kelch_3 PF13415.6 ETO35123.1 - 0.078 13.3 0.1 0.67 10.3 0.1 2.7 4 0 0 4 4 3 0 Galactose oxidase, central domain SPRY PF00622.28 ETO35124.1 - 0.026 14.6 0.9 10 6.3 0.1 3.2 1 1 2 3 3 3 0 SPRY domain SKG6 PF08693.10 ETO35124.1 - 0.49 9.8 6.7 0.28 10.6 0.9 2.3 2 0 0 2 2 2 0 Transmembrane alpha-helix domain WD40 PF00400.32 ETO35125.1 - 3e-12 46.8 2.1 0.00059 20.6 0.7 3.8 3 2 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35125.1 - 0.00064 18.5 0.3 0.14 10.7 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF4979 PF16351.5 ETO35125.1 - 0.00075 19.8 0.1 0.0033 17.7 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF4979) Transket_pyr PF02779.24 ETO35126.1 - 1.4e-57 194.3 0.0 5.7e-57 192.3 0.0 1.9 1 1 0 1 1 1 1 Transketolase, pyrimidine binding domain E1_dh PF00676.20 ETO35126.1 - 6e-54 183.0 0.0 1.1e-53 182.2 0.0 1.3 1 0 0 1 1 1 1 Dehydrogenase E1 component OxoGdeHyase_C PF16870.5 ETO35126.1 - 1.5e-20 73.4 0.0 2.9e-20 72.5 0.0 1.4 1 0 0 1 1 1 1 2-oxoglutarate dehydrogenase C-terminal WD40 PF00400.32 ETO35127.1 - 2.1e-13 50.5 6.8 2.8e-06 27.9 0.3 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35127.1 - 0.0001 21.2 1.3 0.16 10.6 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35127.1 - 0.0065 16.7 0.2 0.13 12.6 0.0 2.3 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Endotoxin_C PF03944.14 ETO35127.1 - 0.1 12.9 0.5 0.17 12.2 0.5 1.3 1 0 0 1 1 1 0 delta endotoxin WD40 PF00400.32 ETO35128.1 - 1.8e-41 139.3 26.5 3.6e-06 27.6 0.5 7.9 7 2 0 7 7 7 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO35128.1 - 4.4e-13 48.7 6.5 0.087 11.4 0.1 6.0 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35128.1 - 1.6e-12 47.6 1.2 0.078 13.3 0.0 6.0 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ras PF00071.22 ETO35129.1 - 1.6e-36 125.4 0.0 2.5e-36 124.7 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO35129.1 - 3.6e-22 78.8 0.0 9.4e-22 77.5 0.0 1.7 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO35129.1 - 4.4e-11 42.5 0.0 7.7e-11 41.8 0.0 1.4 1 0 0 1 1 1 1 ADP-ribosylation factor family Gtr1_RagA PF04670.12 ETO35129.1 - 1.9e-06 27.4 0.0 3.1e-06 26.7 0.0 1.4 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region GTP_EFTU PF00009.27 ETO35129.1 - 4.2e-06 26.4 0.0 7.5e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO35129.1 - 9.8e-05 22.4 0.0 0.00019 21.5 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO35129.1 - 0.00015 21.7 0.0 0.011 15.6 0.0 2.3 2 0 0 2 2 2 1 RsgA GTPase AAA_24 PF13479.6 ETO35129.1 - 0.17 11.6 0.0 0.33 10.6 0.0 1.5 1 1 0 1 1 1 0 AAA domain Band_7 PF01145.25 ETO35130.1 - 0.16 12.0 0.0 12 5.8 0.0 2.2 2 0 0 2 2 2 0 SPFH domain / Band 7 family Clat_adaptor_s PF01217.20 ETO35131.1 - 3.4e-27 95.1 12.4 5.3e-19 68.6 4.0 2.4 1 1 1 2 2 2 2 Clathrin adaptor complex small chain HOOK PF05622.12 ETO35132.1 - 9.9e-05 20.7 0.9 0.00011 20.6 0.9 1.0 1 0 0 1 1 1 1 HOOK protein DUF3450 PF11932.8 ETO35132.1 - 0.00054 19.3 0.2 0.00072 18.9 0.2 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3450) DUF3294 PF07957.11 ETO35132.1 - 0.011 15.5 0.5 0.017 14.8 0.5 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3294) Vps53_N PF04100.12 ETO35132.1 - 0.015 14.3 0.7 0.019 13.9 0.7 1.1 1 0 0 1 1 1 0 Vps53-like, N-terminal Tropomyosin_1 PF12718.7 ETO35132.1 - 0.025 14.7 1.3 0.038 14.2 1.3 1.3 1 0 0 1 1 1 0 Tropomyosin like Rop-like PF05082.13 ETO35132.1 - 0.046 13.5 0.1 0.093 12.6 0.1 1.5 1 0 0 1 1 1 0 Rop-like DUF4482 PF14818.6 ETO35132.1 - 0.07 14.0 2.3 0.11 13.4 2.3 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4482) MctB PF11382.8 ETO35132.1 - 0.077 12.7 0.2 0.11 12.2 0.2 1.1 1 0 0 1 1 1 0 Copper transport outer membrane protein, MctB Uso1_p115_C PF04871.13 ETO35132.1 - 0.083 13.3 2.3 0.16 12.4 2.3 1.4 1 0 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region BBS2_N PF14781.6 ETO35133.1 - 0.0059 16.5 0.0 1.2 9.1 0.0 2.4 2 0 0 2 2 2 2 Ciliary BBSome complex subunit 2, N-terminal CNH PF00780.22 ETO35133.1 - 0.041 13.5 0.0 0.099 12.2 0.0 1.6 2 0 0 2 2 2 0 CNH domain PQQ_3 PF13570.6 ETO35133.1 - 0.056 14.0 1.4 1.4 9.5 0.0 3.0 4 0 0 4 4 4 0 PQQ-like domain WD40 PF00400.32 ETO35134.1 - 7.9e-61 200.6 18.3 1.9e-10 41.2 0.2 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35134.1 - 1e-27 96.3 0.5 0.00047 20.4 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35134.1 - 4.8e-16 58.6 3.3 0.012 14.6 0.0 6.8 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO35134.1 - 1.1e-13 51.5 0.5 9.6e-05 22.3 0.1 4.0 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO35134.1 - 1.7e-08 34.2 4.0 0.00033 20.1 0.1 3.7 1 1 3 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO35134.1 - 1.1e-07 30.9 6.5 0.71 8.4 0.1 5.2 1 1 4 5 5 5 4 Nucleoporin Nup120/160 PALB2_WD40 PF16756.5 ETO35134.1 - 1.5e-05 24.1 4.3 0.79 8.6 0.0 4.7 1 1 4 5 5 5 2 Partner and localizer of BRCA2 WD40 domain PD40 PF07676.12 ETO35134.1 - 5.5e-05 23.0 18.4 0.32 11.0 0.2 6.3 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO35134.1 - 9.6e-05 22.5 2.6 1.9 8.6 0.0 4.8 1 1 4 5 5 5 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO35134.1 - 0.00013 20.6 1.9 0.049 12.2 0.1 2.5 1 1 0 2 2 2 2 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO35134.1 - 0.00021 20.7 0.8 2.6 7.3 0.0 3.8 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal Str_synth PF03088.16 ETO35134.1 - 0.0029 17.7 0.8 12 6.1 0.0 4.5 4 1 1 5 5 5 0 Strictosidine synthase Resistin PF06954.11 ETO35134.1 - 0.021 15.3 0.1 74 4.0 0.0 4.0 3 1 1 4 4 4 0 Resistin PQQ PF01011.21 ETO35134.1 - 0.027 14.4 0.0 58 3.9 0.0 4.5 5 0 0 5 5 5 0 PQQ enzyme repeat EcoRI PF02963.16 ETO35134.1 - 0.042 12.8 0.2 19 4.2 0.0 3.1 2 1 1 3 3 3 0 Restriction endonuclease EcoRI Proteasome_A_N PF10584.9 ETO35134.1 - 1.5 8.5 16.2 4 7.2 0.2 5.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature SpoIIIAH PF12685.7 ETO35135.1 - 9.1e-06 25.6 0.3 0.00084 19.2 0.3 2.3 2 0 0 2 2 2 1 SpoIIIAH-like protein CLN3 PF02487.17 ETO35135.1 - 0.0038 16.3 1.1 0.0053 15.9 0.5 1.6 2 0 0 2 2 2 1 CLN3 protein O-antigen_lig PF13425.6 ETO35135.1 - 0.0057 15.5 4.5 0.0057 15.5 4.5 1.5 1 1 0 1 1 1 1 O-antigen ligase like membrane protein V_ATPase_I PF01496.19 ETO35135.1 - 0.015 13.3 5.9 0.011 13.7 4.3 1.5 1 1 1 2 2 2 0 V-type ATPase 116kDa subunit family SPC25 PF06703.11 ETO35135.1 - 0.022 14.5 2.5 0.033 14.0 1.9 1.6 1 1 0 1 1 1 0 Microsomal signal peptidase 25 kDa subunit (SPC25) NPR3 PF03666.13 ETO35135.1 - 0.037 12.8 11.2 0.068 12.0 11.2 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ureide_permease PF07168.11 ETO35135.1 - 0.049 12.4 0.2 0.099 11.4 0.2 1.6 2 0 0 2 2 2 0 Ureide permease Ctr PF04145.15 ETO35135.1 - 0.049 14.2 7.2 2.8 8.6 4.0 2.9 2 1 1 3 3 3 0 Ctr copper transporter family Mem_trans PF03547.18 ETO35135.1 - 0.14 10.5 0.1 0.2 10.0 0.1 1.3 1 0 0 1 1 1 0 Membrane transport protein FAM176 PF14851.6 ETO35135.1 - 0.27 10.9 10.7 12 5.5 0.0 3.4 2 1 1 3 3 3 0 FAM176 family Voltage_CLC PF00654.20 ETO35135.1 - 0.38 9.9 2.2 2 7.6 2.2 1.9 1 1 0 1 1 1 0 Voltage gated chloride channel CSG2 PF16965.5 ETO35135.1 - 0.44 9.4 10.9 0.58 9.1 7.3 2.4 2 1 1 3 3 3 0 Ceramide synthase regulator CDC45 PF02724.14 ETO35135.1 - 0.58 8.4 17.8 0.022 13.1 11.9 1.5 2 0 0 2 2 2 0 CDC45-like protein RR_TM4-6 PF06459.12 ETO35135.1 - 0.92 9.3 14.2 1.7 8.4 14.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Nucleoside_tran PF01733.18 ETO35135.1 - 1 8.6 5.6 17 4.7 5.5 2.3 1 1 0 1 1 1 0 Nucleoside transporter ALMT PF11744.8 ETO35135.1 - 1.2 7.9 8.5 2.2 7.0 8.5 1.4 1 0 0 1 1 1 0 Aluminium activated malate transporter LAP1C PF05609.12 ETO35135.1 - 1.3 8.0 12.1 3.1 6.8 12.0 1.6 1 1 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Zip PF02535.22 ETO35135.1 - 1.4 8.0 13.2 4.6 6.4 12.4 2.2 1 1 0 1 1 1 0 ZIP Zinc transporter AAA_11 PF13086.6 ETO35135.1 - 3.6 7.3 11.1 6.4 6.5 11.1 1.3 1 0 0 1 1 1 0 AAA domain DAG_kinase_N PF14513.6 ETO35135.1 - 9.2 6.4 11.3 1.1 9.4 6.8 1.7 2 0 0 2 2 2 0 Diacylglycerol kinase N-terminus WD40 PF00400.32 ETO35136.1 - 3.1e-56 186.0 13.3 3.6e-09 37.1 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35136.1 - 6.4e-21 74.5 6.5 0.0014 18.8 0.1 6.1 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35136.1 - 2.4e-14 53.1 1.5 0.0041 16.1 0.1 6.0 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35136.1 - 8.2e-12 45.1 0.5 0.0024 17.2 0.0 3.2 2 1 1 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO35136.1 - 1.1e-09 37.6 4.5 0.052 12.2 0.4 5.7 1 1 3 4 4 4 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO35136.1 - 4.9e-09 36.4 0.8 0.0046 16.9 0.0 3.6 1 1 3 4 4 4 3 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 ETO35136.1 - 6.7e-06 25.9 0.8 0.1 12.1 0.0 2.3 2 0 0 2 2 2 2 PQQ-like domain Cytochrom_D1 PF02239.16 ETO35136.1 - 2.1e-05 23.2 1.4 0.038 12.5 0.0 3.4 1 1 2 4 4 4 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO35136.1 - 8.7e-05 22.6 3.8 2 8.6 0.0 5.1 1 1 4 6 6 6 2 Family of unknown function (DUF5570) Nbas_N PF15492.6 ETO35136.1 - 0.00017 21.0 1.2 0.35 10.2 0.0 3.3 1 1 1 3 3 3 2 Neuroblastoma-amplified sequence, N terminal PQQ PF01011.21 ETO35136.1 - 0.00039 20.2 0.0 15 5.7 0.0 5.1 6 0 0 6 6 6 0 PQQ enzyme repeat PALB2_WD40 PF16756.5 ETO35136.1 - 0.0008 18.4 3.8 3.2 6.6 0.1 4.6 1 1 5 6 6 6 1 Partner and localizer of BRCA2 WD40 domain Me-amine-dh_H PF06433.11 ETO35136.1 - 0.0018 17.2 0.7 4.5 6.0 0.0 3.2 2 2 0 3 3 3 2 Methylamine dehydrogenase heavy chain (MADH) PD40 PF07676.12 ETO35136.1 - 0.002 18.0 3.8 10 6.2 0.2 4.8 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF285 PF03382.14 ETO35136.1 - 0.15 11.8 2.4 5.6 6.8 0.2 3.2 3 2 0 3 3 3 0 Mycoplasma protein of unknown function, DUF285 HPS6 PF15702.5 ETO35136.1 - 0.17 9.8 0.0 5.1 5.0 0.0 2.9 1 1 3 4 4 4 0 Hermansky-Pudlak syndrome 6 protein PH PF00169.29 ETO35137.1 - 3.9e-17 62.7 0.4 9e-17 61.5 0.2 1.6 2 0 0 2 2 2 1 PH domain PH_3 PF14593.6 ETO35137.1 - 0.00059 19.9 0.0 0.001 19.1 0.0 1.3 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO35137.1 - 0.00083 19.8 4.3 0.091 13.2 4.3 2.5 1 1 0 1 1 1 1 Pleckstrin homology domain PH_8 PF15409.6 ETO35137.1 - 0.0071 16.6 0.3 0.013 15.7 0.3 1.5 1 0 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 ETO35137.1 - 0.052 13.9 0.0 0.12 12.8 0.0 1.7 1 1 0 1 1 1 0 Plant pleckstrin homology-like region HGTP_anticodon PF03129.20 ETO35138.1 - 7.1e-12 45.3 0.2 3.6e-11 43.0 0.0 2.4 3 0 0 3 3 3 1 Anticodon binding domain tRNA-synt_2b PF00587.25 ETO35138.1 - 9e-09 35.5 0.0 3.3e-08 33.7 0.0 2.1 1 1 0 1 1 1 1 tRNA synthetase class II core domain (G, H, P, S and T) NPV_P10 PF05531.12 ETO35138.1 - 0.17 12.4 1.0 1.3 9.6 1.3 2.3 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Kelch_2 PF07646.15 ETO35139.1 - 0.0032 17.4 5.1 20 5.3 0.0 4.8 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ETO35139.1 - 0.072 13.4 4.0 3.9 7.9 0.0 3.9 4 0 0 4 4 4 0 Kelch motif Kelch_5 PF13854.6 ETO35139.1 - 1.4 9.0 8.7 3.2 7.8 0.5 4.3 5 0 0 5 5 5 0 Kelch motif WD40 PF00400.32 ETO35140.1 - 1.1e-43 146.3 10.8 1.6e-10 41.4 0.0 6.1 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35140.1 - 7.6e-20 71.0 0.3 0.00036 20.8 0.0 5.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35140.1 - 2.6e-14 52.9 0.2 0.0012 17.9 0.0 5.2 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO35140.1 - 1.2e-10 41.7 0.1 8.6e-05 22.5 0.0 2.6 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A PD40 PF07676.12 ETO35140.1 - 8.3e-10 38.3 5.2 3.4 7.7 0.0 6.3 6 0 0 6 6 6 4 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO35140.1 - 1.3e-08 34.5 0.0 0.00036 20.0 0.0 2.9 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO35140.1 - 9.9e-07 27.8 0.9 0.17 10.5 0.1 4.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO35140.1 - 1e-06 27.6 0.1 0.0033 16.0 0.0 3.1 1 1 1 3 3 3 2 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO35140.1 - 2.6e-05 23.2 4.5 0.14 10.9 0.0 4.2 1 1 4 5 5 5 2 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO35140.1 - 0.00029 20.4 5.8 21 4.9 0.0 5.5 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DPPIV_N PF00930.21 ETO35140.1 - 0.0004 19.3 0.0 3.3 6.4 0.0 3.9 1 1 4 5 5 5 2 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_2 PF13360.6 ETO35140.1 - 0.0018 17.9 0.1 0.022 14.3 0.1 2.4 1 1 0 1 1 1 1 PQQ-like domain DUF5570 PF17731.1 ETO35140.1 - 0.0031 17.6 0.6 12 6.0 0.0 3.6 1 1 3 4 4 4 0 Family of unknown function (DUF5570) Utp8 PF10395.9 ETO35140.1 - 0.017 13.7 0.1 1.1 7.6 0.0 2.1 1 1 1 2 2 2 0 Utp8 family PQQ PF01011.21 ETO35140.1 - 0.027 14.4 0.0 8.9 6.4 0.0 3.4 3 0 0 3 3 3 0 PQQ enzyme repeat UN_NPL4 PF11543.8 ETO35140.1 - 0.052 14.0 0.5 2.4 8.7 0.0 3.2 3 1 0 3 3 3 0 Nuclear pore localisation protein NPL4 WD40 PF00400.32 ETO35141.1 - 2.1e-11 44.2 0.6 2e-05 25.2 0.2 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35141.1 - 0.0042 15.8 0.1 0.26 9.9 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO35141.1 - 0.012 15.5 0.6 1.4 8.8 0.1 2.4 1 1 1 2 2 2 0 Eukaryotic translation initiation factor eIF2A STATa_Ig PF18214.1 ETO35141.1 - 0.079 13.0 0.0 0.13 12.2 0.0 1.4 1 0 0 1 1 1 0 STATa Immunoglobulin-like domain DUF1357 PF07094.11 ETO35143.1 - 0.047 13.8 0.0 0.057 13.5 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1357) TMEM215 PF15746.5 ETO35144.1 - 0.0061 16.0 0.5 0.0082 15.6 0.5 1.1 1 0 0 1 1 1 1 TMEM215 family PPR_3 PF13812.6 ETO35144.1 - 0.039 14.0 1.0 0.09 12.9 1.0 1.7 1 1 0 1 1 1 0 Pentatricopeptide repeat domain CAP_GLY PF01302.25 ETO35145.1 - 1.6e-12 47.2 0.6 2.7e-12 46.5 0.6 1.4 1 0 0 1 1 1 1 CAP-Gly domain PA26 PF04636.13 ETO35147.1 - 0.35 9.7 2.7 0.34 9.8 2.7 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Menin PF05053.13 ETO35147.1 - 0.53 8.6 8.0 0.55 8.5 8.0 1.1 1 0 0 1 1 1 0 Menin Presenilin PF01080.17 ETO35147.1 - 4.4 6.0 6.0 4.7 5.9 6.0 1.2 1 0 0 1 1 1 0 Presenilin KMP11 PF03037.16 ETO35148.1 - 0.16 12.8 0.8 0.32 11.8 0.4 1.7 1 1 1 2 2 2 0 Kinetoplastid membrane protein 11 Mannosyl_trans2 PF04188.13 ETO35150.1 - 0.038 13.3 0.0 0.065 12.5 0.0 1.3 1 0 0 1 1 1 0 Mannosyltransferase (PIG-V) PH_10 PF15411.6 ETO35150.1 - 0.073 13.3 0.8 0.2 11.9 0.0 2.1 2 0 0 2 2 2 0 Pleckstrin homology domain ORF6N PF10543.9 ETO35150.1 - 0.8 10.0 3.9 2.8 8.2 0.8 2.5 2 0 0 2 2 2 0 ORF6N domain Roughex PF06020.11 ETO35151.1 - 0.14 11.3 6.2 0.18 10.9 6.2 1.1 1 0 0 1 1 1 0 Drosophila roughex protein UPF0242 PF06785.11 ETO35153.1 - 0.0006 20.0 10.1 0.0009 19.4 10.1 1.2 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0242) N-terminus WD40 PF00400.32 ETO35153.1 - 0.0014 19.5 0.2 0.27 12.2 0.0 2.5 2 0 0 2 2 2 1 WD domain, G-beta repeat Atg14 PF10186.9 ETO35153.1 - 0.027 13.6 4.7 0.035 13.2 4.7 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Hanta_nucleocap PF00846.18 ETO35153.1 - 0.073 11.5 2.9 0.1 11.1 2.9 1.1 1 0 0 1 1 1 0 Hantavirus nucleocapsid protein CENP-Q PF13094.6 ETO35153.1 - 0.12 12.5 5.1 0.33 11.1 5.1 1.7 1 1 0 1 1 1 0 CENP-Q, a CENPA-CAD centromere complex subunit KELK PF15796.5 ETO35153.1 - 3.4 8.2 12.6 1.2 9.6 8.2 2.4 2 1 1 3 3 3 0 KELK-motif containing domain of MRCK Ser/Thr protein kinase PI_PP_I PF18363.1 ETO35153.1 - 9.7 6.4 10.4 6.2 7.1 5.5 3.0 2 1 2 4 4 4 0 Phosphoinositide phosphatase insertion domain USP7_ICP0_bdg PF12436.8 ETO35154.1 - 0.046 13.0 0.2 0.054 12.8 0.2 1.1 1 0 0 1 1 1 0 ICP0-binding domain of Ubiquitin-specific protease 7 Kelch_6 PF13964.6 ETO35155.1 - 6.3e-06 26.3 2.1 1.8 9.0 0.1 4.6 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO35155.1 - 9.8e-06 25.4 1.2 3 8.0 0.1 4.9 4 1 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO35155.1 - 1.6e-05 24.4 5.3 0.0011 18.5 0.1 4.0 5 0 0 5 5 5 1 Kelch motif Kelch_4 PF13418.6 ETO35155.1 - 0.0031 17.5 0.0 0.26 11.3 0.0 3.6 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35155.1 - 0.025 14.6 1.9 1 9.4 0.3 4.0 5 0 0 5 5 5 0 Kelch motif Kelch_5 PF13854.6 ETO35156.1 - 0.00014 21.8 2.3 1.5 8.9 0.0 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO35156.1 - 0.0063 16.8 1.3 1.2 9.5 0.0 3.9 4 0 0 4 4 4 1 Kelch motif Cupin_2 PF07883.11 ETO35157.1 - 2.6e-11 43.1 0.1 6.7e-11 41.7 0.1 1.7 1 1 0 1 1 1 1 Cupin domain Cupin_1 PF00190.22 ETO35157.1 - 1.4e-07 31.2 0.0 2.1e-07 30.6 0.0 1.3 1 0 0 1 1 1 1 Cupin Cupin_8 PF13621.6 ETO35157.1 - 0.014 15.1 1.0 0.032 14.0 0.7 1.5 1 1 1 2 2 2 0 Cupin-like domain Ectoine_synth PF06339.12 ETO35157.1 - 0.028 14.6 0.1 0.037 14.2 0.1 1.2 1 0 0 1 1 1 0 Ectoine synthase Helicase_RecD PF05127.14 ETO35157.1 - 0.22 11.4 0.0 0.25 11.2 0.0 1.1 1 0 0 1 1 1 0 Helicase FAIM1 PF06905.13 ETO35158.1 - 0.034 13.8 0.0 0.052 13.3 0.0 1.2 1 0 0 1 1 1 0 Fas apoptotic inhibitory molecule (FAIM1) Mis12 PF05859.12 ETO35158.1 - 0.068 13.2 0.8 0.86 9.7 0.8 2.4 1 1 0 1 1 1 0 Mis12 protein Exo84_C PF16528.5 ETO35159.1 - 0.00077 19.3 0.0 0.0018 18.1 0.0 1.6 1 0 0 1 1 1 1 Exocyst component 84 C-terminal Peptidase_S49_N PF08496.10 ETO35159.1 - 0.0031 17.6 4.6 0.0072 16.4 4.6 1.7 1 0 0 1 1 1 1 Peptidase family S49 N-terminal Mem_trans PF03547.18 ETO35159.1 - 0.0078 14.6 0.4 0.0087 14.5 0.4 1.3 1 0 0 1 1 1 1 Membrane transport protein Bap31 PF05529.12 ETO35159.1 - 0.0082 16.0 1.8 0.16 11.8 0.1 2.5 2 0 0 2 2 2 1 Bap31/Bap29 transmembrane region NEMP PF10225.9 ETO35159.1 - 0.023 14.4 2.3 2.8 7.5 0.3 2.3 2 0 0 2 2 2 0 NEMP family Shisa PF13908.6 ETO35159.1 - 0.088 13.0 1.5 0.16 12.2 1.5 1.4 1 0 0 1 1 1 0 Wnt and FGF inhibitory regulator MAP17 PF15807.5 ETO35159.1 - 0.17 12.1 2.6 0.37 11.0 2.6 1.6 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 DUF4834 PF16118.5 ETO35159.1 - 0.9 10.5 6.0 3.2 8.8 6.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) WD40 PF00400.32 ETO35160.1 - 0.057 14.3 0.5 0.31 12.0 0.0 2.2 2 0 0 2 2 2 0 WD domain, G-beta repeat 2OG-FeII_Oxy_2 PF13532.6 ETO35163.1 - 1.4e-17 64.5 0.0 1.7e-17 64.3 0.0 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily CPDase PF07823.11 ETO35164.1 - 1.4e-07 31.4 0.1 1.1e-06 28.5 0.1 2.3 1 1 1 2 2 2 1 Cyclic phosphodiesterase-like protein Methyltransf_12 PF08242.12 ETO35164.1 - 0.0097 16.6 2.4 2.9 8.7 0.7 2.4 2 0 0 2 2 2 2 Methyltransferase domain 2_5_RNA_ligase2 PF13563.6 ETO35164.1 - 0.052 13.5 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 2'-5' RNA ligase superfamily MscS_TM PF12794.7 ETO35164.1 - 0.19 10.5 0.6 0.28 10.0 0.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 FAM176 PF14851.6 ETO35164.1 - 0.2 11.3 6.3 0.5 10.0 1.6 2.4 2 0 0 2 2 2 0 FAM176 family CENP-B_dimeris PF09026.10 ETO35164.1 - 0.32 11.4 12.8 0.22 11.9 1.6 2.5 2 0 0 2 2 2 0 Centromere protein B dimerisation domain Apis_Csd PF11671.8 ETO35164.1 - 5.6 7.0 14.3 6.4 6.8 2.1 2.4 2 0 0 2 2 2 0 Complementary sex determiner protein PBP1_TM PF14812.6 ETO35164.1 - 8.3 6.9 14.6 2.9 8.3 5.1 2.4 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal FA_desaturase PF00487.24 ETO35165.1 - 4.9e-25 88.8 18.5 7.6e-25 88.2 18.5 1.2 1 0 0 1 1 1 1 Fatty acid desaturase DLIC PF05783.11 ETO35166.1 - 0.00014 20.8 0.2 0.00024 20.1 0.0 1.4 2 0 0 2 2 2 1 Dynein light intermediate chain (DLIC) DUF5542 PF17696.1 ETO35166.1 - 0.12 12.5 1.6 0.4 10.8 1.6 1.8 1 0 0 1 1 1 0 Family of unknown function (DUF5542) WD40 PF00400.32 ETO35167.1 - 3.6e-22 78.2 12.5 5.7e-07 30.1 0.4 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35167.1 - 1.9e-07 30.2 0.7 0.082 11.5 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35167.1 - 1e-06 28.9 0.0 0.12 12.7 0.0 3.1 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35167.1 - 8.3e-06 25.3 1.3 0.00086 18.7 0.2 2.7 1 1 1 2 2 2 2 WD40-like domain TPR_12 PF13424.6 ETO35168.1 - 1.8e-63 210.8 9.6 1.6e-20 73.2 0.2 5.9 4 2 2 6 6 6 5 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35168.1 - 3.5e-62 204.7 0.0 7.7e-11 41.5 0.0 7.5 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35168.1 - 1.3e-51 168.9 5.1 1.8e-07 30.7 0.0 7.4 7 0 0 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35168.1 - 6.7e-48 158.6 50.9 1.3e-09 37.4 1.8 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35168.1 - 3.1e-44 145.6 32.3 2.5e-07 30.3 0.4 8.0 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35168.1 - 3.2e-41 136.1 50.8 4.9e-08 32.6 1.6 7.7 8 0 0 8 8 7 7 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35168.1 - 2e-23 81.0 11.8 0.0062 16.8 0.2 8.0 7 1 0 7 7 7 5 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35168.1 - 4.6e-14 52.0 12.2 0.026 15.1 0.6 7.8 8 0 0 8 8 7 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35168.1 - 9.6e-14 50.8 42.8 0.018 14.7 1.5 10.3 8 3 3 11 11 11 5 TPR repeat TPR_16 PF13432.6 ETO35168.1 - 5.4e-13 49.3 0.0 0.27 11.9 0.0 6.9 7 1 0 7 7 6 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO35168.1 - 1.2e-12 47.8 0.0 4e-05 23.2 0.0 2.7 1 1 3 4 4 4 3 MalT-like TPR region TPR_14 PF13428.6 ETO35168.1 - 3.6e-12 46.0 0.0 1.1 10.3 0.0 6.5 7 1 1 8 8 6 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO35168.1 - 4.1e-11 42.6 34.0 0.0049 16.8 0.2 7.7 8 0 0 8 8 8 4 Tetratricopeptide repeat DUF5113 PF17140.4 ETO35168.1 - 2.8e-08 33.7 23.8 0.39 10.5 0.4 6.1 4 2 2 6 6 6 5 Domain of unknown function (DUF5113) PPR PF01535.20 ETO35168.1 - 1.3e-07 31.4 25.9 0.17 12.2 0.3 7.9 8 0 0 8 8 7 2 PPR repeat ANAPC3 PF12895.7 ETO35168.1 - 1.1e-06 28.7 22.3 0.004 17.3 0.9 5.6 2 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_19 PF14559.6 ETO35168.1 - 3.8e-06 27.3 4.8 0.24 11.9 0.0 4.9 5 2 1 6 6 5 2 Tetratricopeptide repeat Mob_Pre PF01076.19 ETO35168.1 - 3.9e-06 26.8 15.3 0.019 14.8 0.2 3.9 2 1 2 4 4 4 3 Plasmid recombination enzyme RPN7 PF10602.9 ETO35168.1 - 3.8e-05 23.4 17.6 0.052 13.3 2.4 5.2 1 1 1 4 4 4 2 26S proteasome subunit RPN7 DUF2225 PF09986.9 ETO35168.1 - 0.00025 20.8 19.2 0.074 12.8 1.2 4.5 2 1 3 5 5 5 2 Uncharacterized protein conserved in bacteria (DUF2225) HTH_Bact PF18768.1 ETO35168.1 - 0.0014 18.2 12.3 11 5.7 0.1 6.5 6 1 0 6 6 6 0 Helix-turn-helix bacterial domain YecM PF06185.12 ETO35168.1 - 0.0018 18.0 2.3 14 5.3 0.1 4.7 1 1 4 5 5 5 0 YecM protein OrfA PF17495.2 ETO35168.1 - 0.0023 18.1 0.1 4.5 7.5 0.0 4.5 1 1 5 6 6 6 1 Vpr-like OrfA MIT PF04212.18 ETO35168.1 - 0.003 17.6 31.0 0.53 10.4 0.4 6.6 7 0 0 7 7 6 3 MIT (microtubule interacting and transport) domain TPR_21 PF09976.9 ETO35168.1 - 0.0093 15.7 6.0 0.067 12.9 0.0 4.1 2 2 2 4 4 4 1 Tetratricopeptide repeat-like domain Sel1 PF08238.12 ETO35168.1 - 0.029 15.1 19.5 12 6.7 0.1 7.0 6 2 0 6 6 6 0 Sel1 repeat DUF4810 PF16068.5 ETO35168.1 - 0.057 14.0 9.8 12 6.6 0.3 5.4 6 1 0 6 6 5 0 Domain of unknown function (DUF4810) DUF627 PF04781.12 ETO35168.1 - 0.078 13.0 8.5 4.2 7.4 1.6 4.9 3 1 2 5 5 5 0 Protein of unknown function (DUF627) SERTA PF06031.13 ETO35168.1 - 0.14 11.9 0.2 78 3.1 0.1 3.5 3 0 0 3 3 3 0 SERTA motif OEP PF02321.18 ETO35168.1 - 0.17 11.7 3.7 3.1 7.6 0.1 3.2 2 1 0 3 3 3 0 Outer membrane efflux protein DUF3450 PF11932.8 ETO35168.1 - 0.21 10.9 5.9 16 4.7 0.1 4.0 1 1 3 4 4 4 0 Protein of unknown function (DUF3450) SPO22 PF08631.10 ETO35168.1 - 0.39 10.2 9.1 0.71 9.3 0.1 3.3 3 1 0 3 3 3 0 Meiosis protein SPO22/ZIP4 like FATC PF02260.20 ETO35168.1 - 0.69 9.8 4.8 1.3e+02 2.6 0.2 4.9 6 0 0 6 6 5 0 FATC domain SHNi-TPR PF10516.9 ETO35168.1 - 0.87 9.1 12.1 6.1 6.4 0.0 5.4 8 0 0 8 8 7 0 SHNi-TPR Peripla_BP_7 PF18610.1 ETO35168.1 - 1.9 8.7 8.3 31 4.8 0.4 4.2 1 1 3 4 4 4 0 Periplasmic binding protein domain Tim54 PF11711.8 ETO35171.1 - 0.011 14.5 0.9 0.013 14.3 0.9 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 eIF3_p135 PF12807.7 ETO35171.1 - 0.16 12.0 1.9 0.19 11.7 1.2 1.5 1 1 0 1 1 1 0 Translation initiation factor eIF3 subunit 135 WD40 PF00400.32 ETO35173.1 - 7.6e-59 194.3 19.6 1.2e-10 41.7 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35173.1 - 8.9e-24 83.6 0.8 0.0057 16.9 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35173.1 - 3.6e-09 36.0 3.2 0.42 9.5 0.0 5.5 1 1 4 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO35173.1 - 8e-08 31.4 1.5 0.012 14.3 0.1 3.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35173.1 - 1e-07 31.6 7.1 0.022 14.1 0.1 3.7 1 1 2 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO35173.1 - 1.8e-07 30.9 7.2 0.94 9.5 0.1 6.3 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO35173.1 - 2.3e-07 29.7 0.6 0.098 11.2 0.0 3.1 1 1 1 3 3 3 3 Cytochrome D1 heme domain Nbas_N PF15492.6 ETO35173.1 - 3.7e-06 26.5 2.7 1 8.6 0.0 4.9 3 1 2 5 5 5 2 Neuroblastoma-amplified sequence, N terminal PQQ_2 PF13360.6 ETO35173.1 - 5.2e-05 22.9 0.3 0.18 11.3 0.0 3.3 1 1 0 2 2 2 1 PQQ-like domain Me-amine-dh_H PF06433.11 ETO35173.1 - 5.3e-05 22.2 0.0 0.068 12.0 0.0 3.1 1 1 1 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) PQQ PF01011.21 ETO35173.1 - 6.4e-05 22.7 0.0 9.8 6.3 0.0 5.7 7 0 0 7 7 7 1 PQQ enzyme repeat Utp8 PF10395.9 ETO35173.1 - 0.0016 17.0 0.4 0.24 9.9 0.0 2.9 1 1 2 3 3 3 1 Utp8 family DUF1513 PF07433.11 ETO35173.1 - 0.0029 16.8 0.1 1.6 7.7 0.0 3.0 2 1 1 3 3 3 2 Protein of unknown function (DUF1513) Coatomer_WDAD PF04053.14 ETO35173.1 - 0.0091 15.1 4.6 0.2 10.7 0.8 2.9 1 1 0 2 2 2 1 Coatomer WD associated region DPPIV_N PF00930.21 ETO35173.1 - 0.016 14.0 0.1 7.7 5.2 0.0 3.4 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF2963 PF11178.8 ETO35173.1 - 0.024 14.4 6.3 2.8 7.7 0.1 5.3 4 1 2 6 6 6 0 Protein of unknown function (DUF2963) Proteasome_A_N PF10584.9 ETO35173.1 - 0.18 11.5 5.0 16 5.3 0.1 4.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature ADD_ATRX PF17981.1 ETO35174.1 - 0.12 12.3 0.1 0.23 11.4 0.1 1.4 1 0 0 1 1 1 0 Cysteine Rich ADD domain EF-hand_1 PF00036.32 ETO35176.1 - 2.1 8.1 6.0 0.34 10.5 1.5 2.1 2 0 0 2 2 2 0 EF hand CH PF00307.31 ETO35178.1 - 1.8e-12 47.4 0.0 8.1e-08 32.4 0.0 2.3 2 0 0 2 2 2 2 Calponin homology (CH) domain Amidohydro_2 PF04909.14 ETO35179.1 - 2.9e-19 70.0 0.0 3.5e-19 69.7 0.0 1.1 1 0 0 1 1 1 1 Amidohydrolase WD40 PF00400.32 ETO35180.1 - 5.3e-22 77.7 17.5 4.2e-07 30.5 0.1 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35180.1 - 4.7e-07 30.0 0.0 0.023 15.0 0.0 2.3 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35180.1 - 1.5e-05 23.9 1.6 0.19 10.3 0.1 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35180.1 - 0.0012 18.3 1.6 0.0071 15.7 1.3 2.0 1 1 1 2 2 2 1 WD40-like domain DUF4221 PF13970.6 ETO35180.1 - 0.037 13.6 4.3 0.25 10.8 4.2 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) TPR_12 PF13424.6 ETO35181.1 - 2.7e-54 181.4 4.0 1.3e-14 54.2 0.1 4.3 2 1 3 5 5 5 5 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35181.1 - 3e-28 96.4 22.4 6.3e-08 32.1 0.9 6.7 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35181.1 - 3.3e-27 93.6 0.0 2.7e-06 27.0 0.1 6.5 6 0 0 6 6 6 6 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35181.1 - 2.1e-26 89.9 0.1 7e-06 25.7 0.0 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35181.1 - 6.6e-21 72.7 25.2 1.2e-05 25.1 0.0 7.3 7 0 0 7 7 7 5 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35181.1 - 2.5e-20 70.9 12.9 0.00019 21.3 0.5 6.6 7 0 0 7 7 7 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35181.1 - 2.7e-07 30.1 12.6 0.12 12.0 1.2 5.5 5 1 1 6 6 6 3 TPR repeat TPR_14 PF13428.6 ETO35181.1 - 1.9e-06 28.2 0.0 2.9 8.9 0.0 4.8 5 0 0 5 5 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35181.1 - 1.7e-05 24.9 6.0 0.012 15.9 0.0 4.8 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35181.1 - 9.4e-05 22.8 2.3 0.48 11.2 0.1 5.3 6 0 0 6 6 5 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO35181.1 - 0.00038 19.9 0.0 0.002 17.5 0.0 2.0 1 1 1 2 2 2 2 MalT-like TPR region TPR_16 PF13432.6 ETO35181.1 - 0.00078 20.0 0.0 5 7.9 0.0 4.7 5 1 1 6 6 5 1 Tetratricopeptide repeat Fer4_12 PF13353.6 ETO35181.1 - 0.0028 17.9 3.5 0.015 15.6 0.7 2.5 1 1 1 2 2 2 1 4Fe-4S single cluster domain MIT PF04212.18 ETO35181.1 - 0.0028 17.7 8.5 0.22 11.6 0.2 4.0 4 0 0 4 4 4 2 MIT (microtubule interacting and transport) domain DUF2428 PF10350.9 ETO35181.1 - 0.0045 16.3 0.5 0.021 14.1 0.0 2.1 2 0 0 2 2 2 1 Putative death-receptor fusion protein (DUF2428) DUF5113 PF17140.4 ETO35181.1 - 0.049 13.4 11.4 2.6 7.8 0.3 4.1 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) PPR PF01535.20 ETO35181.1 - 0.48 10.8 11.0 8.4 6.9 0.1 5.4 5 0 0 5 5 4 0 PPR repeat PA PF02225.22 ETO35182.1 - 0.0032 17.4 0.0 0.0036 17.3 0.0 1.2 1 0 0 1 1 1 1 PA domain NRIP1_repr_2 PF15688.5 ETO35182.1 - 0.052 13.4 0.0 0.069 13.0 0.0 1.1 1 0 0 1 1 1 0 Nuclear receptor-interacting protein 1 repression 2 DUF3922 PF13059.6 ETO35182.1 - 0.11 12.9 0.0 0.2 12.1 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3992) Cys_knot PF00007.22 ETO35183.1 - 0.0088 16.3 4.6 0.011 16.0 4.6 1.3 1 0 0 1 1 1 1 Cystine-knot domain WD40 PF00400.32 ETO35184.1 - 1.2e-14 54.4 9.9 3.7e-05 24.4 0.3 3.4 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35184.1 - 0.0019 16.9 0.4 0.0046 15.7 0.0 1.7 1 1 0 2 2 2 1 Nucleoporin Nup120/160 WD40 PF00400.32 ETO35185.1 - 2.8e-101 328.6 56.2 2.8e-09 37.5 0.4 16.4 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35185.1 - 3.9e-29 100.8 14.6 0.0065 16.8 0.0 11.5 3 2 10 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35185.1 - 3.4e-22 79.1 20.4 1.7e-06 27.6 0.2 6.2 4 2 1 6 6 6 5 WD40-like domain Ge1_WD40 PF16529.5 ETO35185.1 - 1.9e-18 66.5 9.7 0.0011 18.0 0.0 9.3 3 3 3 8 8 8 6 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO35185.1 - 1.3e-07 31.2 1.0 2.7e-07 30.1 1.0 1.4 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO35185.1 - 6.6e-05 23.0 0.1 0.00016 21.7 0.1 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_3 PF13576.6 ETO35185.1 - 0.0017 18.4 0.6 0.005 17.0 0.6 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF727 PF05303.12 ETO35185.1 - 0.0019 18.3 4.8 19 5.4 0.3 5.9 5 1 1 6 6 6 0 Protein of unknown function (DUF727) PD40 PF07676.12 ETO35185.1 - 0.0063 16.4 9.6 18 5.4 0.0 6.8 8 0 0 8 8 7 0 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO35185.1 - 0.054 12.0 4.0 9.8 4.6 0.0 4.3 3 1 1 5 5 5 0 Cytochrome D1 heme domain DUF3475 PF11961.8 ETO35185.1 - 0.067 13.3 2.3 14 5.8 0.0 4.8 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) Corona_NS8 PF12093.8 ETO35185.1 - 0.11 13.1 0.0 6.6 7.3 0.0 3.1 2 0 0 2 2 2 0 Coronavirus NS8 protein PQQ_2 PF13360.6 ETO35185.1 - 0.3 10.6 2.6 41 3.6 0.3 3.8 2 1 2 4 4 4 0 PQQ-like domain Pneumo_M2 PF07380.11 ETO35185.1 - 3.2 8.1 6.0 1.3 9.4 1.0 2.9 3 0 0 3 3 2 0 Pneumovirus M2 protein Kelch_6 PF13964.6 ETO35186.1 - 0.011 16.0 4.5 2.8 8.4 0.9 2.6 2 0 0 2 2 2 0 Kelch motif Kelch_4 PF13418.6 ETO35186.1 - 0.26 11.3 4.2 0.37 10.8 0.6 2.3 1 1 1 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35186.1 - 0.46 10.5 5.6 2.4 8.2 2.9 2.4 2 0 0 2 2 2 0 Kelch motif Kelch_6 PF13964.6 ETO35187.1 - 2.1e-05 24.7 8.4 0.022 15.0 0.2 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO35187.1 - 0.00046 20.1 10.1 0.00094 19.2 0.1 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO35187.1 - 0.00048 19.7 5.9 0.066 12.8 0.1 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO35187.1 - 0.017 15.1 0.1 0.017 15.1 0.1 3.6 4 0 0 4 4 4 0 Kelch motif DUF1236 PF06823.12 ETO35187.1 - 0.058 13.3 0.0 0.13 12.2 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF1236) Kelch_3 PF13415.6 ETO35187.1 - 0.72 10.2 2.6 18 5.8 0.0 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain Peptidase_M23 PF01551.22 ETO35188.1 - 1.3e-15 57.4 0.4 3.5e-15 56.0 0.1 1.9 2 0 0 2 2 2 1 Peptidase family M23 RRM_1 PF00076.22 ETO35188.1 - 0.0073 16.1 0.6 0.018 14.9 0.0 2.0 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Zip PF02535.22 ETO35188.1 - 0.089 12.0 6.0 0.18 11.0 6.0 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter RnfC_N PF13375.6 ETO35188.1 - 0.092 12.7 0.0 2.1 8.4 0.0 2.5 2 0 0 2 2 2 0 RnfC Barrel sandwich hybrid domain RR_TM4-6 PF06459.12 ETO35188.1 - 0.54 10.0 7.0 1.4 8.6 7.0 1.6 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO35188.1 - 0.64 8.2 6.5 1.2 7.3 6.5 1.4 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ETO35188.1 - 5 5.8 13.4 11 4.7 13.4 1.4 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO35188.1 - 8.4 5.0 10.3 15 4.2 9.1 1.9 2 0 0 2 2 2 0 Presenilin fn3 PF00041.21 ETO35189.1 - 0.012 16.0 0.5 0.063 13.6 0.1 2.3 2 1 0 2 2 2 0 Fibronectin type III domain PixA PF12306.8 ETO35190.1 - 0.15 12.2 1.9 1.8 8.7 0.1 2.0 2 0 0 2 2 2 0 Inclusion body protein Spt20 PF12090.8 ETO35191.1 - 0.01 15.5 4.2 0.012 15.2 4.2 1.2 1 0 0 1 1 1 0 Spt20 family NOA36 PF06524.12 ETO35191.1 - 0.054 12.8 8.9 0.077 12.3 8.9 1.2 1 0 0 1 1 1 0 NOA36 protein DUF2722 PF10846.8 ETO35191.1 - 0.22 10.4 7.9 0.26 10.2 7.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) CDC45 PF02724.14 ETO35191.1 - 0.32 9.2 8.5 0.39 9.0 8.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Sigma70_r1_1 PF03979.14 ETO35191.1 - 5 7.3 13.2 8.5 6.5 13.2 1.3 1 0 0 1 1 1 0 Sigma-70 factor, region 1.1 Sporozoite_P67 PF05642.11 ETO35191.1 - 7.5 4.5 6.5 9.8 4.1 6.5 1.1 1 0 0 1 1 1 0 Sporozoite P67 surface antigen GET2 PF08690.10 ETO35192.1 - 0.0027 17.4 1.1 0.0034 17.1 1.1 1.1 1 0 0 1 1 1 1 GET complex subunit GET2 SR-25 PF10500.9 ETO35192.1 - 0.0097 15.5 6.8 0.013 15.1 6.8 1.1 1 0 0 1 1 1 1 Nuclear RNA-splicing-associated protein Borrelia_P83 PF05262.11 ETO35192.1 - 0.01 14.4 4.9 0.012 14.1 4.9 1.0 1 0 0 1 1 1 0 Borrelia P83/100 protein Tir_receptor_C PF07489.11 ETO35192.1 - 0.038 14.0 6.6 0.056 13.4 6.6 1.2 1 0 0 1 1 1 0 Translocated intimin receptor (Tir) C-terminus Ephrin_lbd PF01404.19 ETO35192.1 - 0.063 13.3 3.2 0.093 12.8 3.2 1.3 1 0 0 1 1 1 0 Ephrin receptor ligand binding domain DUF4599 PF15371.6 ETO35193.1 - 0.51 10.9 2.2 1 10.0 2.2 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4599) HMGL-like PF00682.19 ETO35194.1 - 8.5e-35 120.6 0.1 1e-34 120.3 0.1 1.0 1 0 0 1 1 1 1 HMGL-like PUB PF09409.10 ETO35196.1 - 0.00046 20.1 0.1 0.0012 18.8 0.1 1.7 1 0 0 1 1 1 1 PUB domain WD40 PF00400.32 ETO35197.1 - 2.5e-29 100.9 3.9 2.5e-09 37.6 0.1 4.3 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35197.1 - 7.9e-12 45.3 0.3 0.009 16.3 0.0 4.3 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35197.1 - 6.1e-10 38.6 0.0 0.0052 15.8 0.0 3.6 1 1 2 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO35197.1 - 6.9e-06 26.2 7.7 0.0076 16.5 0.6 5.1 6 0 0 6 6 5 2 Kelch motif Kelch_1 PF01344.25 ETO35197.1 - 7.2e-06 25.5 1.0 0.071 12.7 0.5 3.6 3 0 0 3 3 3 1 Kelch motif PD40 PF07676.12 ETO35197.1 - 5e-05 23.1 0.8 1.2 9.1 0.1 3.5 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Kelch_2 PF07646.15 ETO35197.1 - 7.1e-05 22.6 1.8 0.093 12.7 0.3 3.9 3 0 0 3 3 3 1 Kelch motif Cytochrom_D1 PF02239.16 ETO35197.1 - 0.00096 17.8 0.1 0.0025 16.4 0.1 1.7 1 1 0 1 1 1 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO35197.1 - 0.001 17.9 0.7 1.5 7.3 0.0 3.2 1 1 2 3 3 3 2 Nucleoporin Nup120/160 Kelch_4 PF13418.6 ETO35197.1 - 0.0017 18.3 0.6 0.0076 16.2 0.1 2.3 2 0 0 2 2 2 1 Galactose oxidase, central domain PQQ PF01011.21 ETO35197.1 - 0.0094 15.8 1.1 0.048 13.6 0.1 2.5 2 0 0 2 2 2 1 PQQ enzyme repeat DPPIV_N PF00930.21 ETO35197.1 - 0.022 13.6 0.0 0.73 8.5 0.0 2.7 2 1 1 3 3 3 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Kelch_3 PF13415.6 ETO35197.1 - 0.024 14.9 0.1 0.89 9.9 0.0 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35197.1 - 0.032 14.2 9.9 0.5 10.4 0.8 4.0 4 0 0 4 4 4 0 Kelch motif ArlS_N PF18719.1 ETO35197.1 - 0.24 11.6 1.9 1.7 8.9 0.0 3.1 3 1 0 3 3 3 0 ArlS sensor domain Sulfotransfer_2 PF03567.14 ETO35198.1 - 9.8e-12 45.3 1.2 1.7e-11 44.5 1.2 1.3 1 0 0 1 1 1 1 Sulfotransferase family Lzipper-MIP1 PF14389.6 ETO35199.1 - 0.0007 19.8 13.6 0.026 14.8 1.2 3.9 3 1 0 3 3 3 2 Leucine-zipper of ternary complex factor MIP1 TPR_MLP1_2 PF07926.12 ETO35199.1 - 0.0012 18.9 6.1 0.0012 18.9 6.1 3.9 3 1 0 3 3 2 1 TPR/MLP1/MLP2-like protein DUF2935 PF11155.8 ETO35199.1 - 0.025 14.9 6.2 1.3 9.4 1.1 3.3 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) DUF4051 PF13260.6 ETO35199.1 - 0.026 14.2 0.0 0.062 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF4051) DUF4140 PF13600.6 ETO35199.1 - 0.029 14.8 8.3 0.1 13.0 0.0 3.9 3 1 0 3 3 3 0 N-terminal domain of unknown function (DUF4140) Prp19 PF08606.11 ETO35199.1 - 0.081 12.9 4.2 1.2 9.2 0.8 3.6 2 1 0 2 2 2 0 Prp19/Pso4-like DUF1192 PF06698.11 ETO35199.1 - 0.3 11.2 3.1 6.2 6.9 0.2 3.2 3 0 0 3 3 2 0 Protein of unknown function (DUF1192) DASH_Dam1 PF08653.10 ETO35199.1 - 0.39 10.5 14.3 4.1 7.3 0.1 4.5 5 0 0 5 5 5 0 DASH complex subunit Dam1 AIP3 PF03915.13 ETO35199.1 - 0.6 9.1 25.1 4.2 6.3 14.1 2.4 1 1 1 2 2 2 0 Actin interacting protein 3 TSC22 PF01166.18 ETO35199.1 - 0.72 10.2 13.8 0.11 12.9 1.8 3.8 2 1 1 3 3 3 0 TSC-22/dip/bun family FlaC_arch PF05377.11 ETO35199.1 - 0.88 10.0 15.5 7 7.1 0.3 4.4 3 2 2 5 5 5 0 Flagella accessory protein C (FlaC) BMFP PF04380.13 ETO35199.1 - 1.1 9.8 11.9 0.8 10.2 1.1 4.2 4 1 0 4 4 4 0 Membrane fusogenic activity Fez1 PF06818.15 ETO35199.1 - 1.4 9.3 30.1 1 9.7 15.2 2.7 2 1 1 3 3 3 0 Fez1 CODH_A_N PF18537.1 ETO35199.1 - 1.8 8.7 4.4 20 5.3 0.2 3.7 3 1 0 3 3 3 0 Carbon monoxide dehydrogenase subunit alpha N-terminal domain DUF641 PF04859.12 ETO35199.1 - 1.8 8.9 17.1 0.059 13.7 2.7 2.9 2 1 1 3 3 3 0 Plant protein of unknown function (DUF641) PhoU PF01895.19 ETO35199.1 - 2.9 8.4 5.4 1.4 9.4 2.1 2.2 2 0 0 2 2 2 0 PhoU domain Spc7 PF08317.11 ETO35199.1 - 3.1 6.6 32.8 0.031 13.2 6.6 3.3 2 1 2 4 4 4 0 Spc7 kinetochore protein FliT PF05400.13 ETO35199.1 - 4.4 8.2 13.2 2.8 8.8 0.7 3.9 3 1 1 4 4 4 0 Flagellar protein FliT APG6_N PF17675.1 ETO35199.1 - 6.7 7.3 31.2 0.43 11.1 5.1 3.7 1 1 1 3 3 2 0 Apg6 coiled-coil region DUF4407 PF14362.6 ETO35199.1 - 8.1 5.7 18.4 4.7e+02 -0.1 18.5 2.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) Spore_II_R PF09551.10 ETO35200.1 - 0.75 10.3 10.5 0.92 10.0 0.6 2.6 3 0 0 3 3 3 0 Stage II sporulation protein R (spore_II_R) Sec16 PF12932.7 ETO35200.1 - 1.6 9.3 5.1 25 5.5 0.5 2.7 2 0 0 2 2 2 0 Vesicle coat trafficking protein Sec16 mid-region FKS1_dom1 PF14288.6 ETO35200.1 - 6.6 7.1 6.3 6.3 7.1 0.0 2.8 2 1 0 3 3 3 0 1,3-beta-glucan synthase subunit FKS1, domain-1 PQ-loop PF04193.14 ETO35201.1 - 2.6e-26 91.1 18.0 2.5e-15 56.0 4.8 3.2 3 0 0 3 3 3 2 PQ loop repeat Gly-zipper_Omp PF13488.6 ETO35202.1 - 1.3e-07 31.5 84.0 0.0067 16.4 0.7 6.9 1 1 3 4 4 4 3 Glycine zipper Rick_17kDa_Anti PF05433.15 ETO35202.1 - 0.0067 16.3 20.4 0.0067 16.3 20.4 7.0 2 1 2 4 4 4 2 Glycine zipper 2TM domain NAAA-beta PF15508.6 ETO35202.1 - 0.049 13.9 0.2 11 6.5 0.0 3.9 2 2 1 3 3 3 0 beta subunit of N-acylethanolamine-hydrolyzing acid amidase Gly-zipper_YMGG PF13441.6 ETO35202.1 - 0.079 12.7 67.6 63 3.4 0.4 6.5 1 1 2 3 3 3 0 YMGG-like Gly-zipper DUF1048 PF06304.11 ETO35202.1 - 0.12 12.8 1.2 8.6 6.9 0.1 2.4 1 1 1 2 2 2 0 Protein of unknown function (DUF1048) PB1 PF00564.24 ETO35203.1 - 0.0045 16.9 0.0 0.014 15.3 0.0 1.8 2 0 0 2 2 2 1 PB1 domain MIR PF02815.19 ETO35203.1 - 0.024 14.5 0.6 0.091 12.6 0.4 2.0 1 1 0 1 1 1 0 MIR domain Pkinase PF00069.25 ETO35205.1 - 3.6e-48 164.2 0.2 7.5e-47 159.9 0.2 2.3 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35205.1 - 1.6e-29 103.0 0.1 1.1e-28 100.3 0.1 2.1 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO35205.1 - 3.5e-05 23.3 0.0 6.2e-05 22.5 0.0 1.4 1 0 0 1 1 1 1 Kinase-like PIP49_C PF12260.8 ETO35205.1 - 0.024 14.3 0.0 0.06 13.0 0.0 1.6 1 0 0 1 1 1 0 Protein-kinase domain of FAM69 BLYB PF05289.11 ETO35205.1 - 0.24 11.6 6.3 0.52 10.5 0.2 3.0 3 0 0 3 3 3 0 Borrelia hemolysin accessory protein PPR_2 PF13041.6 ETO35207.1 - 3.4e-08 33.5 0.5 0.0001 22.4 0.0 2.9 2 0 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETO35207.1 - 6e-05 23.0 5.9 0.27 11.6 0.2 4.0 4 0 0 4 4 4 2 PPR repeat PPR_3 PF13812.6 ETO35207.1 - 0.0018 18.3 0.6 13 6.0 0.0 3.7 1 1 2 3 3 3 2 Pentatricopeptide repeat domain PPR_1 PF12854.7 ETO35207.1 - 0.049 13.3 0.0 1.1 9.1 0.0 2.8 2 0 0 2 2 2 0 PPR repeat WD40 PF00400.32 ETO35210.1 - 4.2e-26 90.7 17.1 1e-06 29.3 0.9 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35210.1 - 2.5e-12 46.9 0.3 0.015 15.6 0.0 4.0 3 1 1 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35210.1 - 4.8e-06 25.5 6.1 0.0089 14.7 1.5 3.6 1 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35210.1 - 0.0013 18.1 4.5 0.1 11.9 1.2 3.0 1 1 0 2 2 2 2 WD40-like domain TPR_12 PF13424.6 ETO35211.1 - 2.4e-106 348.1 9.1 1.4e-22 79.8 0.0 6.1 2 2 5 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35211.1 - 1.1e-58 193.6 0.0 1.6e-09 37.3 0.0 9.0 8 1 1 9 9 9 6 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35211.1 - 3.4e-58 191.2 43.1 1e-09 37.8 1.5 9.2 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35211.1 - 4.6e-55 179.7 5.4 7.2e-09 35.1 0.1 9.0 9 0 0 9 9 9 6 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35211.1 - 1.2e-49 162.4 44.5 4e-08 32.8 0.3 8.9 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35211.1 - 9.2e-48 156.6 30.9 2.6e-08 33.4 0.2 9.2 8 1 1 9 9 9 8 Tetratricopeptide repeat TPR_16 PF13432.6 ETO35211.1 - 6.6e-20 71.5 0.0 0.0034 18.0 0.0 6.5 3 2 2 6 6 5 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO35211.1 - 6.8e-19 66.9 0.0 0.1 13.5 0.0 7.6 4 2 4 8 8 8 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35211.1 - 8.7e-19 66.9 6.4 0.28 11.9 0.0 8.3 9 0 0 9 9 8 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35211.1 - 2.9e-17 61.7 20.8 0.014 15.8 0.0 9.3 9 2 0 9 9 8 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35211.1 - 5.1e-17 61.3 54.2 0.00014 21.4 0.3 11.8 8 5 4 12 12 12 8 TPR repeat DUF5113 PF17140.4 ETO35211.1 - 2e-11 44.0 13.2 0.1 12.4 0.5 6.3 6 0 0 6 6 6 4 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO35211.1 - 1.2e-08 34.8 20.3 1.5 8.9 0.2 7.3 7 0 0 7 7 7 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO35211.1 - 1.5e-08 35.0 1.0 0.42 11.2 0.0 4.0 5 1 0 5 5 3 3 Tetratricopeptide repeat PPR PF01535.20 ETO35211.1 - 1.1e-07 31.6 19.1 0.23 11.8 0.1 7.4 8 0 0 8 8 7 2 PPR repeat TPR_9 PF13371.6 ETO35211.1 - 1.1e-07 31.9 0.0 0.084 13.0 0.0 4.2 3 2 1 4 4 4 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO35211.1 - 5.6e-07 29.7 12.1 0.08 13.2 0.2 4.8 2 2 4 6 6 6 3 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO35211.1 - 7.9e-07 29.1 33.9 1.6 8.8 0.3 8.5 8 1 1 9 9 9 3 MIT (microtubule interacting and transport) domain DUF4810 PF16068.5 ETO35211.1 - 7.3e-06 26.4 7.1 2.2 8.9 0.0 5.8 5 2 0 5 5 5 2 Domain of unknown function (DUF4810) TPR_MalT PF17874.1 ETO35211.1 - 3.1e-05 23.5 0.0 0.0054 16.1 0.0 3.0 1 1 2 3 3 3 1 MalT-like TPR region Sel1 PF08238.12 ETO35211.1 - 0.00016 22.3 17.2 11 6.8 0.7 7.7 7 1 0 7 7 7 0 Sel1 repeat RPN7 PF10602.9 ETO35211.1 - 0.0031 17.2 15.1 3.1 7.5 0.1 5.4 3 2 1 5 5 5 1 26S proteasome subunit RPN7 DUF627 PF04781.12 ETO35211.1 - 0.015 15.3 5.5 69 3.5 0.0 4.9 3 1 2 5 5 5 0 Protein of unknown function (DUF627) SHNi-TPR PF10516.9 ETO35211.1 - 0.019 14.4 11.1 9 5.9 0.1 6.1 7 0 0 7 7 6 0 SHNi-TPR SPO22 PF08631.10 ETO35211.1 - 0.058 12.9 14.1 0.9 9.0 0.2 4.8 2 1 2 5 5 5 0 Meiosis protein SPO22/ZIP4 like HisG PF01634.18 ETO35211.1 - 0.068 13.1 0.7 6.1 6.8 0.1 3.0 1 1 2 3 3 3 0 ATP phosphoribosyltransferase FATC PF02260.20 ETO35211.1 - 0.083 12.7 0.0 22 5.0 0.0 3.2 3 0 0 3 3 3 0 FATC domain Pep3_Vps18 PF05131.14 ETO35211.1 - 0.1 12.4 4.3 51 3.7 0.0 4.5 5 0 0 5 5 4 0 Pep3/Vps18/deep orange family GvpK PF05121.12 ETO35211.1 - 0.11 12.6 0.1 11 6.2 0.0 3.3 3 1 0 3 3 3 0 Gas vesicle protein K MerR_1 PF13411.6 ETO35211.1 - 0.24 11.5 5.7 2.7 8.1 0.2 3.9 4 0 0 4 4 4 0 MerR HTH family regulatory protein Clathrin PF00637.20 ETO35211.1 - 0.25 11.2 16.5 24 4.8 0.2 5.8 3 2 0 5 5 5 0 Region in Clathrin and VPS DUF5475 PF17569.2 ETO35211.1 - 0.41 11.0 3.7 16 5.9 0.0 4.3 6 0 0 6 6 3 0 Family of unknown function (DUF5475) PHM7_cyt PF14703.6 ETO35211.1 - 1.2 9.4 12.8 0.72 10.1 1.9 2.9 1 1 2 3 3 3 0 Cytosolic domain of 10TM putative phosphate transporter BAR_3 PF16746.5 ETO35211.1 - 1.8 8.2 14.0 4.9 6.8 0.4 4.9 4 1 0 5 5 5 0 BAR domain of APPL family PKK PF12474.8 ETO35211.1 - 6.4 6.9 7.3 22 5.2 0.1 4.2 3 1 1 4 4 4 0 Polo kinase kinase Ras PF00071.22 ETO35213.1 - 7e-48 162.3 1.0 1e-47 161.7 1.0 1.2 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO35213.1 - 7.1e-25 87.6 0.2 2.2e-24 85.9 0.1 1.9 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO35213.1 - 2.1e-10 40.3 0.2 2.9e-10 39.9 0.2 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family Phage_integrase PF00589.22 ETO35213.1 - 0.0029 17.4 1.6 0.0068 16.2 0.2 1.9 2 0 0 2 2 2 1 Phage integrase family zinc_ribbon_9 PF14369.6 ETO35214.1 - 0.054 13.7 0.1 0.11 12.8 0.1 1.5 1 0 0 1 1 1 0 zinc-ribbon Pectate_lyase_3 PF12708.7 ETO35216.1 - 0.00036 20.4 0.9 0.00036 20.4 0.9 2.5 3 0 0 3 3 3 1 Pectate lyase superfamily protein DUF4509 PF14970.6 ETO35217.1 - 0.12 12.2 1.5 2.6 7.9 0.0 2.1 1 1 0 2 2 2 0 Domain of unknown function (DUF4509) Ins134_P3_kin PF05770.11 ETO35219.1 - 0.12 11.8 0.1 0.17 11.4 0.1 1.2 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain Peptidase_C14 PF00656.22 ETO35222.1 - 1.4e-16 61.2 0.2 2.6e-16 60.3 0.2 1.4 1 0 0 1 1 1 1 Caspase domain MCM PF00493.23 ETO35222.1 - 0.034 13.2 0.0 0.061 12.4 0.0 1.5 1 0 0 1 1 1 0 MCM P-loop domain Copper-bind PF00127.20 ETO35222.1 - 0.11 13.0 0.2 11 6.6 0.0 2.3 2 0 0 2 2 2 0 Copper binding proteins, plastocyanin/azurin family AAA_assoc_C PF09821.9 ETO35222.1 - 0.32 11.5 3.2 0.58 10.7 0.8 2.6 3 0 0 3 3 3 0 C-terminal AAA-associated domain DUF4033 PF13225.6 ETO35223.1 - 0.00066 19.6 7.2 0.3 11.1 0.1 2.6 2 1 0 2 2 2 2 Domain of unknown function (DUF4033) FF PF01846.19 ETO35224.1 - 0.01 16.0 0.3 4.1 7.7 0.1 2.7 2 0 0 2 2 2 0 FF domain FbpA PF05833.11 ETO35224.1 - 1.9 7.2 11.1 0.39 9.4 7.3 1.7 2 0 0 2 2 2 0 Fibronectin-binding protein A N-terminus (FbpA) DUF1500 PF07389.12 ETO35225.1 - 0.0036 17.3 2.3 0.021 14.9 0.1 2.3 2 0 0 2 2 2 1 Protein of unknown function (DUF1500) HDAC4_Gln PF12203.8 ETO35225.1 - 0.19 11.9 5.0 0.5 10.6 5.0 1.7 1 0 0 1 1 1 0 Glutamine rich N terminal domain of histone deacetylase 4 Cys_knot PF00007.22 ETO35226.1 - 0.035 14.4 5.4 0.039 14.2 5.4 1.2 1 0 0 1 1 1 0 Cystine-knot domain Mss4 PF04421.13 ETO35226.1 - 0.04 14.1 1.1 0.054 13.6 1.1 1.4 1 1 0 1 1 1 0 Mss4 protein WD40 PF00400.32 ETO35227.1 - 1e-15 57.8 8.1 9.6e-06 26.3 0.1 4.0 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35227.1 - 0.00011 22.4 0.0 0.96 9.8 0.0 3.1 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain DUF5046 PF16465.5 ETO35227.1 - 0.009 15.5 0.0 0.014 14.9 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF5046) Nup160 PF11715.8 ETO35227.1 - 0.029 13.0 0.3 8.7 4.8 0.1 2.9 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Bet_v_1 PF00407.19 ETO35227.1 - 0.11 12.4 0.5 9.7 6.1 0.0 2.9 3 0 0 3 3 3 0 Pathogenesis-related protein Bet v I family WD40 PF00400.32 ETO35228.1 - 3e-24 84.8 15.6 3.7e-05 24.4 3.1 5.6 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO35228.1 - 7.1e-08 31.5 2.0 0.24 10.0 0.0 3.7 1 1 2 4 4 4 4 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35228.1 - 2.6e-07 30.8 0.5 0.96 9.8 0.0 4.1 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO35230.1 - 4.2e-24 84.3 12.7 1.7e-07 31.8 0.0 4.5 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35230.1 - 2.7e-08 32.9 1.9 0.0055 15.4 0.1 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35230.1 - 3.3e-08 33.7 0.0 0.0043 17.3 0.0 2.9 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain CpXC PF14353.6 ETO35231.1 - 0.00054 20.0 1.8 0.00068 19.7 1.8 1.1 1 0 0 1 1 1 1 CpXC protein AAA_30 PF13604.6 ETO35232.1 - 9.9e-39 133.0 0.5 9.9e-39 133.0 0.5 1.6 2 0 0 2 2 2 1 AAA domain TrwC PF08751.11 ETO35232.1 - 1.4e-09 37.9 0.8 2.6e-09 37.0 0.8 1.4 1 0 0 1 1 1 1 TrwC relaxase AAA_19 PF13245.6 ETO35232.1 - 1.6e-09 38.2 0.5 3.9e-09 37.0 0.5 1.6 1 0 0 1 1 1 1 AAA domain ABC_tran PF00005.27 ETO35232.1 - 6.2e-05 23.5 4.1 0.071 13.6 0.3 2.7 1 1 1 2 2 2 2 ABC transporter AAA_22 PF13401.6 ETO35232.1 - 0.00069 19.9 0.6 0.0023 18.2 0.6 1.9 1 1 0 1 1 1 1 AAA domain AAA_11 PF13086.6 ETO35232.1 - 0.0027 17.6 1.9 0.39 10.5 0.0 2.9 3 1 0 3 3 3 2 AAA domain NTPase_1 PF03266.15 ETO35232.1 - 0.046 13.6 1.5 2.6 7.9 0.3 2.5 2 0 0 2 2 2 0 NTPase AAA PF00004.29 ETO35232.1 - 0.068 13.6 0.1 0.21 12.0 0.1 1.9 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_29 PF13555.6 ETO35232.1 - 0.13 12.0 1.2 4.8 7.0 0.3 2.5 2 0 0 2 2 2 0 P-loop containing region of AAA domain ResIII PF04851.15 ETO35232.1 - 4.4 7.3 5.4 2.7 8.0 1.2 2.5 2 2 0 2 2 2 0 Type III restriction enzyme, res subunit TPR_12 PF13424.6 ETO35233.1 - 5.4e-59 196.4 8.7 5.6e-21 74.6 0.2 4.4 2 1 3 5 5 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35233.1 - 3.8e-32 109.3 1.3 3.8e-09 36.1 0.0 4.9 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35233.1 - 3.2e-23 80.0 1.7 6.3e-07 29.0 0.0 4.0 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35233.1 - 1.3e-22 78.6 11.7 1.7e-07 30.8 0.2 5.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35233.1 - 4.8e-14 51.3 16.9 1.7e-05 24.7 0.5 5.1 5 0 0 5 5 3 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35233.1 - 7.3e-11 41.3 10.9 5.7e-05 22.9 0.1 5.3 5 0 0 5 5 4 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35233.1 - 2.7e-09 36.8 7.6 0.067 13.6 0.1 5.4 5 0 0 5 5 5 3 Tetratricopeptide repeat Lipase_3 PF01764.25 ETO35233.1 - 2.4e-05 24.2 0.0 0.0001 22.2 0.0 2.0 2 0 0 2 2 2 1 Lipase (class 3) TPR_16 PF13432.6 ETO35233.1 - 3.7e-05 24.3 0.0 0.086 13.5 0.0 3.7 1 1 2 3 3 3 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO35233.1 - 4.4e-05 22.9 0.6 0.32 10.5 0.0 4.1 3 0 0 3 3 3 1 SHNi-TPR DUF2974 PF11187.8 ETO35233.1 - 0.00024 20.8 0.1 0.00072 19.2 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2974) TPR_14 PF13428.6 ETO35233.1 - 0.00029 21.4 0.0 32 5.7 0.0 5.1 5 0 0 5 5 4 0 Tetratricopeptide repeat DUF4404 PF14357.6 ETO35233.1 - 0.00036 21.1 1.3 20 5.9 0.0 5.8 4 1 1 6 6 5 0 Domain of unknown function (DUF4404) NB-ARC PF00931.22 ETO35233.1 - 0.0013 17.9 0.0 0.0028 16.9 0.0 1.4 1 0 0 1 1 1 1 NB-ARC domain AAA_22 PF13401.6 ETO35233.1 - 0.0015 18.8 0.2 0.028 14.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain ABC_tran PF00005.27 ETO35233.1 - 0.0041 17.6 0.0 0.017 15.7 0.0 2.1 1 0 0 1 1 1 1 ABC transporter HCR PF07111.12 ETO35233.1 - 0.0053 14.9 0.1 0.0083 14.3 0.1 1.2 1 0 0 1 1 1 1 Alpha helical coiled-coil rod protein (HCR) TPR_6 PF13174.6 ETO35233.1 - 0.0092 16.6 4.5 3.9 8.3 0.0 5.6 6 0 0 6 6 5 1 Tetratricopeptide repeat CbiA PF01656.23 ETO35233.1 - 0.017 15.2 0.0 0.059 13.4 0.0 1.9 1 0 0 1 1 1 0 CobQ/CobB/MinD/ParA nucleotide binding domain IstB_IS21 PF01695.17 ETO35233.1 - 0.053 13.3 0.3 0.23 11.2 0.0 2.2 2 0 0 2 2 2 0 IstB-like ATP binding protein AAA_16 PF13191.6 ETO35233.1 - 0.076 13.4 0.1 0.31 11.4 0.0 2.0 2 0 0 2 2 2 0 AAA ATPase domain ATPase PF06745.13 ETO35233.1 - 0.079 12.3 0.0 0.16 11.3 0.0 1.5 1 0 0 1 1 1 0 KaiC CAP PF00188.26 ETO35233.1 - 0.098 13.5 0.0 0.33 11.8 0.0 1.9 2 0 0 2 2 1 0 Cysteine-rich secretory protein family MIT PF04212.18 ETO35233.1 - 0.15 12.1 12.1 0.16 12.0 0.4 4.3 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain Fis1_TPR_C PF14853.6 ETO35233.1 - 1.1 9.4 10.6 37 4.5 0.1 5.3 6 0 0 6 6 5 0 Fis1 C-terminal tetratricopeptide repeat TPR_11 PF13414.6 ETO35233.1 - 1.5 8.6 8.5 18 5.1 0.1 4.8 4 1 1 5 5 5 0 TPR repeat WD40 PF00400.32 ETO35234.1 - 2.9e-37 126.0 27.7 1.8e-06 28.5 1.4 7.0 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35234.1 - 1.3e-10 41.5 0.1 0.0035 17.6 0.0 4.7 4 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35234.1 - 3e-09 36.1 5.4 0.15 10.7 0.0 4.9 1 1 3 4 4 4 4 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO35234.1 - 0.008 15.8 2.4 0.0091 15.6 1.0 1.9 1 1 1 2 2 2 1 Domain of unknown function (DUF4221) Epimerase PF01370.21 ETO35235.1 - 8.2e-25 87.7 0.0 1.8e-24 86.5 0.0 1.5 1 1 0 1 1 1 1 NAD dependent epimerase/dehydratase family 3Beta_HSD PF01073.19 ETO35235.1 - 2.2e-20 72.8 0.0 3.3e-20 72.2 0.0 1.3 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family NAD_binding_10 PF13460.6 ETO35235.1 - 3.9e-14 53.0 0.0 7e-14 52.1 0.0 1.4 1 0 0 1 1 1 1 NAD(P)H-binding GDP_Man_Dehyd PF16363.5 ETO35235.1 - 5.7e-13 49.0 0.0 1.3e-12 47.8 0.0 1.6 1 1 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ETO35235.1 - 2e-10 40.3 0.0 1.2e-08 34.5 0.0 2.1 1 1 0 1 1 1 1 Male sterility protein NmrA PF05368.13 ETO35235.1 - 7.9e-09 35.4 0.0 1.9e-08 34.1 0.0 1.6 2 0 0 2 2 2 1 NmrA-like family adh_short PF00106.25 ETO35235.1 - 2.3e-06 27.2 0.0 5e-06 26.1 0.0 1.6 1 1 0 1 1 1 1 short chain dehydrogenase KR PF08659.10 ETO35235.1 - 3.9e-05 23.6 0.0 8.2e-05 22.6 0.0 1.4 1 0 0 1 1 1 1 KR domain Polysacc_synt_2 PF02719.15 ETO35235.1 - 0.00013 21.2 0.0 0.00027 20.2 0.0 1.5 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein adh_short_C2 PF13561.6 ETO35235.1 - 0.00083 19.0 0.0 0.0013 18.4 0.0 1.3 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase RmlD_sub_bind PF04321.17 ETO35235.1 - 0.00095 18.3 0.0 0.0015 17.7 0.0 1.3 1 0 0 1 1 1 1 RmlD substrate binding domain MEA1 PF06910.11 ETO35236.1 - 0.063 13.9 0.5 9.4 6.9 0.1 2.6 2 0 0 2 2 2 0 Male enhanced antigen 1 (MEA1) DUF3987 PF13148.6 ETO35237.1 - 0.69 8.9 2.7 1.6 7.7 2.7 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) DUF4408 PF14364.6 ETO35238.1 - 0.33 10.7 3.6 0.82 9.5 3.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4408) Glycoprot_B_PH2 PF17417.2 ETO35239.1 - 0.0095 16.2 0.6 0.3 11.4 0.5 2.5 2 0 0 2 2 2 1 Herpesvirus Glycoprotein B PH-like domain DUF4883 PF16224.5 ETO35239.1 - 0.12 12.6 0.9 0.29 11.4 0.6 1.8 2 0 0 2 2 2 0 DOmain of unknown function (DUF4883) DUF4566 PF15130.6 ETO35241.1 - 0.012 15.0 1.2 0.015 14.8 1.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4566) AlgF PF11182.8 ETO35241.1 - 0.046 13.5 0.4 0.052 13.3 0.4 1.1 1 0 0 1 1 1 0 Alginate O-acetyl transferase AlgF DUF1754 PF08555.10 ETO35241.1 - 0.68 10.8 15.0 3.2 8.6 15.0 1.9 1 1 0 1 1 1 0 Eukaryotic family of unknown function (DUF1754) AP3D1 PF06375.11 ETO35241.1 - 1.5 9.1 10.9 1.9 8.7 10.9 1.1 1 0 0 1 1 1 0 AP-3 complex subunit delta-1 SH3_13 PF18335.1 ETO35241.1 - 2.7 7.9 9.7 2.7 7.9 8.1 1.8 1 1 1 2 2 2 0 ATP-dependent RecD-like DNA helicase SH3 domain Kelch_2 PF07646.15 ETO35242.1 - 4e-08 32.9 1.3 0.013 15.5 0.4 4.5 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO35242.1 - 6.7e-08 32.6 1.2 0.00073 19.7 0.2 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO35242.1 - 4.2e-07 29.5 1.1 0.0044 16.6 0.4 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO35242.1 - 4.6e-05 23.3 6.9 0.0034 17.4 0.8 4.5 6 0 0 6 6 6 1 Kelch motif Kelch_4 PF13418.6 ETO35242.1 - 0.00026 20.9 0.2 0.49 10.4 0.0 3.0 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO35242.1 - 0.00068 19.9 0.3 0.083 13.2 0.0 3.8 5 0 0 5 5 5 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO35242.1 - 0.014 14.6 0.1 3.8 6.6 0.0 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase PH PF00169.29 ETO35243.1 - 0.00038 20.9 0.7 0.0015 19.0 0.2 2.3 2 0 0 2 2 2 1 PH domain DUF4798 PF16055.5 ETO35243.1 - 0.022 15.0 1.4 0.022 15.0 1.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4798) Tox-PLDMTX PF15645.6 ETO35243.1 - 0.038 14.3 0.3 0.2 11.9 0.0 2.3 3 0 0 3 3 3 0 Dermonecrotoxin of the Papain-like fold Med15 PF09606.10 ETO35244.1 - 0.01 14.6 31.0 0.012 14.3 31.0 1.1 1 0 0 1 1 1 1 ARC105 or Med15 subunit of Mediator complex non-fungal HSD3 PF15244.6 ETO35244.1 - 0.02 14.4 6.6 0.022 14.3 6.6 1.1 1 0 0 1 1 1 0 Spermatogenesis-associated protein 7, or HSD3 HtaA PF04213.13 ETO35244.1 - 0.057 13.9 3.8 0.076 13.5 3.8 1.2 1 0 0 1 1 1 0 Htaa TFIIA PF03153.13 ETO35244.1 - 0.065 13.2 23.5 0.071 13.1 23.5 1.0 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit Cdh1_DBD_1 PF18196.1 ETO35244.1 - 0.079 13.3 6.4 0.12 12.7 6.4 1.2 1 0 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Adaptin_binding PF10199.9 ETO35244.1 - 0.22 12.1 9.1 0.36 11.4 9.1 1.3 1 0 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 Metalloenzyme PF01676.18 ETO35244.1 - 0.49 9.7 2.1 0.27 10.6 0.4 1.4 2 0 0 2 2 2 0 Metalloenzyme superfamily FAM60A PF15396.6 ETO35244.1 - 0.83 9.6 8.7 1.1 9.3 8.7 1.2 1 0 0 1 1 1 0 Protein Family FAM60A eIF3g PF12353.8 ETO35244.1 - 1.6 9.1 10.7 2.3 8.6 10.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit G CCDC53 PF10152.9 ETO35244.1 - 3.5 8.0 13.3 4.9 7.6 13.3 1.2 1 0 0 1 1 1 0 Subunit CCDC53 of WASH complex DDHD PF02862.17 ETO35244.1 - 6.8 6.8 9.6 8.7 6.4 9.6 1.1 1 0 0 1 1 1 0 DDHD domain Tubulin PF00091.25 ETO35245.1 - 0.012 15.8 0.1 0.021 15.0 0.1 1.5 1 1 0 1 1 1 0 Tubulin/FtsZ family, GTPase domain UL141 PF16758.5 ETO35245.1 - 0.12 12.1 0.0 0.25 11.0 0.0 1.5 1 1 0 1 1 1 0 Herpes-like virus membrane glycoprotein UL141 FH2 PF02181.23 ETO35246.1 - 3.7e-06 26.3 0.2 3.7e-06 26.3 0.2 1.9 1 1 1 2 2 2 1 Formin Homology 2 Domain CHAD PF05235.14 ETO35246.1 - 0.00074 19.6 0.7 0.0011 19.0 0.7 1.3 1 0 0 1 1 1 1 CHAD domain SesA PF17107.5 ETO35246.1 - 0.013 15.7 0.7 0.24 11.6 0.7 2.1 1 1 1 2 2 2 0 N-terminal domain on NACHT_NTPase and P-loop NTPases CorA PF01544.18 ETO35246.1 - 0.031 13.6 0.9 0.034 13.5 0.9 1.2 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein Rx_N PF18052.1 ETO35246.1 - 0.059 13.6 2.9 0.49 10.7 0.9 2.7 1 1 2 3 3 3 0 Rx N-terminal domain DUF3047 PF11249.8 ETO35246.1 - 0.073 12.5 0.1 0.15 11.5 0.0 1.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3047) Folliculin PF11704.8 ETO35246.1 - 0.15 11.9 1.3 0.2 11.5 1.3 1.2 1 0 0 1 1 1 0 Vesicle coat protein involved in Golgi to plasma membrane transport TMPIT PF07851.13 ETO35246.1 - 0.47 9.7 4.7 0.67 9.1 4.7 1.2 1 0 0 1 1 1 0 TMPIT-like protein FH2 PF02181.23 ETO35247.1 - 5.1e-70 236.5 5.3 5.1e-70 236.5 5.3 2.2 2 0 0 2 2 2 2 Formin Homology 2 Domain CCDC53 PF10152.9 ETO35247.1 - 2e-15 57.5 14.1 7.9e-08 32.9 5.7 3.2 4 1 0 4 4 4 2 Subunit CCDC53 of WASH complex Allexi_40kDa PF05549.11 ETO35247.1 - 0.077 12.5 4.4 0.046 13.2 1.8 1.9 2 0 0 2 2 2 0 Allexivirus 40kDa protein YfhD PF14151.6 ETO35247.1 - 1.5 9.0 5.6 2.4 8.3 0.0 3.5 3 0 0 3 3 3 0 YfhD-like protein Flagellin_N PF00669.20 ETO35249.1 - 0.067 13.3 1.8 0.1 12.7 0.3 2.1 2 0 0 2 2 2 0 Bacterial flagellin N-terminal helical region XPC-binding PF09280.11 ETO35249.1 - 0.079 12.7 4.9 2.3 8.0 0.0 3.8 3 1 0 3 3 3 0 XPC-binding domain DUF1993 PF09351.10 ETO35249.1 - 0.35 11.0 2.6 1.5 8.9 0.0 2.7 2 1 1 3 3 3 0 Domain of unknown function (DUF1993) Anti-adapt_IraP PF10796.9 ETO35249.1 - 1.8 9.2 7.1 2 9.0 0.1 3.6 4 0 0 4 4 4 0 Sigma-S stabilisation anti-adaptor protein DUF4365 PF14280.6 ETO35250.1 - 0.043 13.8 0.1 0.097 12.6 0.1 1.6 1 1 0 2 2 2 0 Domain of unknown function (DUF4365) p31comet PF06581.12 ETO35251.1 - 0.013 14.6 1.4 0.018 14.2 1.4 1.2 1 0 0 1 1 1 0 Mad1 and Cdc20-bound-Mad2 binding HrpB2 PF09487.10 ETO35251.1 - 0.21 12.0 4.0 6.9 7.1 0.2 2.8 2 1 1 3 3 3 0 Bacterial type III secretion protein (HrpB2) DUF4407 PF14362.6 ETO35251.1 - 0.42 9.9 16.3 0.57 9.5 16.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Virul_Fac PF10139.9 ETO35251.1 - 1.7 6.8 13.7 2.1 6.4 13.7 1.0 1 0 0 1 1 1 0 Putative bacterial virulence factor PNP_UDP_1 PF01048.20 ETO35252.1 - 1.9e-27 96.1 0.0 2.5e-27 95.6 0.0 1.1 1 0 0 1 1 1 1 Phosphorylase superfamily NUP PF06516.11 ETO35252.1 - 0.13 11.4 0.0 0.19 11.0 0.0 1.2 1 0 0 1 1 1 0 Purine nucleoside permease (NUP) Kelch_1 PF01344.25 ETO35253.1 - 1.4e-07 30.9 0.3 7.3e-06 25.5 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO35253.1 - 2.9e-06 27.4 1.2 0.016 15.5 0.2 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO35253.1 - 5.1e-05 23.2 0.1 0.0013 18.7 0.1 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO35253.1 - 0.00053 20.2 0.1 0.016 15.5 0.0 3.3 4 0 0 4 4 4 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO35253.1 - 0.013 14.7 0.0 2.8 7.0 0.0 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Kelch_5 PF13854.6 ETO35253.1 - 0.025 14.6 4.6 4 7.5 0.7 4.4 5 0 0 5 5 5 0 Kelch motif DUF2272 PF10030.9 ETO35253.1 - 0.091 12.5 0.0 0.31 10.8 0.0 1.7 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_2 PF07646.15 ETO35253.1 - 2 8.5 10.1 12 6.1 0.0 4.1 5 1 0 5 5 5 0 Kelch motif CUE PF02845.16 ETO35254.1 - 0.0029 17.3 0.0 0.0061 16.2 0.0 1.6 1 0 0 1 1 1 1 CUE domain DUF5531 PF17671.1 ETO35254.1 - 0.04 13.8 1.1 0.098 12.5 1.1 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5531) WD40 PF00400.32 ETO35255.1 - 1.1e-26 92.5 20.3 8.1e-07 29.6 0.4 6.0 6 1 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35255.1 - 1.9e-07 31.3 0.9 0.63 10.4 0.0 4.6 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Peptidase_C6 PF00851.18 ETO35255.1 - 0.0072 15.3 2.2 0.012 14.5 1.5 1.6 1 1 0 1 1 1 1 Helper component proteinase Aph-1 PF06105.12 ETO35255.1 - 0.29 10.5 3.4 0.5 9.7 1.1 2.2 2 0 0 2 2 2 0 Aph-1 protein fn3_PAP PF17808.1 ETO35255.1 - 1.2 9.3 7.4 5 7.3 0.1 2.9 3 0 0 3 3 3 0 Fn3-like domain from Purple Acid Phosphatase DUF4512 PF14975.6 ETO35256.1 - 0.012 16.4 0.1 0.028 15.2 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4512) ECSCR PF15820.5 ETO35256.1 - 0.016 15.0 0.9 0.043 13.6 0.1 2.1 1 1 1 2 2 2 0 Endothelial cell-specific chemotaxis regulator Shisa PF13908.6 ETO35256.1 - 0.14 12.4 2.7 0.28 11.4 2.2 1.7 1 1 0 1 1 1 0 Wnt and FGF inhibitory regulator DUF4834 PF16118.5 ETO35256.1 - 0.16 13.0 1.1 0.5 11.4 1.1 1.9 1 1 0 1 1 1 0 Domain of unknown function (DUF4834) Band_7 PF01145.25 ETO35257.1 - 1.5e-07 31.6 3.8 1.5e-07 31.6 3.1 1.5 1 1 0 1 1 1 1 SPFH domain / Band 7 family DUF1465 PF07323.12 ETO35257.1 - 0.018 14.9 0.9 0.027 14.3 0.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1465) Peptidase_S66 PF02016.15 ETO35257.1 - 0.049 13.7 0.6 0.098 12.8 0.5 1.6 1 1 0 1 1 1 0 LD-carboxypeptidase N-terminal domain ANAPC15 PF15243.6 ETO35257.1 - 0.062 13.7 0.6 0.1 13.0 0.6 1.3 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 15 ASD2 PF08687.11 ETO35258.1 - 0.025 14.1 11.4 0.033 13.7 4.8 2.1 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Ecl1 PF12855.7 ETO35258.1 - 0.063 14.4 14.6 0.086 14.0 14.6 1.2 1 0 0 1 1 1 0 ECL1/2/3 zinc binding proteins SSP160 PF06933.11 ETO35258.1 - 0.16 10.1 9.7 0.23 9.6 9.7 1.2 1 0 0 1 1 1 0 Special lobe-specific silk protein SSP160 Apt1 PF10351.9 ETO35258.1 - 0.26 10.1 15.2 0.37 9.6 15.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain Ndc1_Nup PF09531.10 ETO35258.1 - 0.3 9.7 7.2 0.39 9.4 7.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup SOG2 PF10428.9 ETO35258.1 - 1.1 8.3 15.1 1.6 7.9 15.1 1.2 1 0 0 1 1 1 0 RAM signalling pathway protein Methyltransf_32 PF13679.6 ETO35258.1 - 1.4 8.9 6.6 0.3 11.1 1.3 2.0 2 0 0 2 2 2 0 Methyltransferase domain Peptidase_S64 PF08192.11 ETO35258.1 - 1.6 7.1 12.3 2.1 6.7 12.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 DUF4604 PF15377.6 ETO35258.1 - 3.3 8.1 19.1 3.1 8.2 14.0 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4604) DUF4551 PF15087.6 ETO35258.1 - 5.7 5.6 12.6 7.6 5.2 12.6 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) Annexin PF00191.20 ETO35259.1 - 8.7e-19 67.4 2.6 2.4e-11 43.5 0.1 3.3 3 0 0 3 3 3 2 Annexin Hemagglutinin PF00509.18 ETO35259.1 - 0.18 10.2 0.0 0.32 9.3 0.0 1.3 1 0 0 1 1 1 0 Haemagglutinin YqzL PF14006.6 ETO35259.1 - 0.65 10.4 2.2 2 8.9 0.0 2.9 2 0 0 2 2 2 0 YqzL-like protein Glyco_hydro_38C PF07748.13 ETO35260.1 - 1.7e-21 77.3 0.0 4.1e-21 76.1 0.0 1.6 1 0 0 1 1 1 1 Glycosyl hydrolases family 38 C-terminal domain Glyco_hydro38C2 PF17677.1 ETO35260.1 - 0.12 12.5 0.0 0.3 11.2 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolases family 38 C-terminal beta sandwich domain H_lectin PF09458.10 ETO35260.1 - 0.32 11.2 7.0 0.11 12.7 2.3 2.7 2 0 0 2 2 2 0 H-type lectin domain zf-H2C2_2 PF13465.6 ETO35261.1 - 9.3e-07 29.0 13.7 0.003 17.9 0.1 5.0 4 0 0 4 4 4 2 Zinc-finger double domain zf-C2H2 PF00096.26 ETO35261.1 - 2e-06 27.9 22.1 0.0055 17.1 0.8 4.3 4 0 0 4 4 4 3 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO35261.1 - 0.00025 21.6 18.7 0.079 13.8 0.7 4.5 4 0 0 4 4 4 3 C2H2-type zinc finger zf-met PF12874.7 ETO35261.1 - 0.0036 17.6 4.4 0.0075 16.6 0.2 2.7 2 0 0 2 2 2 1 Zinc-finger of C2H2 type FOXP-CC PF16159.5 ETO35261.1 - 0.024 15.2 0.6 0.089 13.4 0.6 1.9 1 0 0 1 1 1 0 FOXP coiled-coil domain zf-Sec23_Sec24 PF04810.15 ETO35261.1 - 0.062 13.4 2.9 0.94 9.6 0.3 3.3 2 0 0 2 2 2 0 Sec23/Sec24 zinc finger LIM PF00412.22 ETO35261.1 - 0.11 12.8 5.1 5 7.4 0.6 3.1 2 0 0 2 2 2 0 LIM domain zf-C2H2_8 PF15909.5 ETO35261.1 - 0.55 10.6 5.3 15 6.0 0.4 2.9 1 1 1 2 2 2 0 C2H2-type zinc ribbon zf-C2H2_jaz PF12171.8 ETO35261.1 - 1 9.7 14.2 0.34 11.3 0.7 3.9 3 1 1 4 4 4 0 Zinc-finger double-stranded RNA-binding zf-C2H2_6 PF13912.6 ETO35261.1 - 2.4 8.2 7.7 0.25 11.4 0.4 2.9 3 0 0 3 3 3 0 C2H2-type zinc finger Ribonuc_red_lgC PF02867.15 ETO35262.1 - 2e-135 452.3 0.2 1.1e-72 245.3 0.0 3.4 2 1 1 3 3 3 3 Ribonucleotide reductase, barrel domain Ribonuc_red_lgN PF00317.21 ETO35262.1 - 2.2e-21 75.6 0.0 4.4e-21 74.7 0.0 1.5 1 0 0 1 1 1 1 Ribonucleotide reductase, all-alpha domain ATP-cone PF03477.16 ETO35262.1 - 4.9e-15 55.9 0.0 1e-14 54.9 0.0 1.6 1 0 0 1 1 1 1 ATP cone domain DNA_topoisoIV PF00521.20 ETO35265.1 - 9.1e-91 304.9 3.1 9.1e-91 304.9 3.1 3.5 2 2 1 3 3 3 1 DNA gyrase/topoisomerase IV, subunit A TOPRIM_C PF16898.5 ETO35265.1 - 5.2e-40 136.7 9.1 5.2e-40 136.7 9.1 2.7 2 0 0 2 2 2 1 C-terminal associated domain of TOPRIM DNA_gyraseB PF00204.25 ETO35265.1 - 2.2e-15 56.6 1.7 8.2e-15 54.7 1.7 2.0 1 0 0 1 1 1 1 DNA gyrase B HATPase_c PF02518.26 ETO35265.1 - 2.2e-11 44.2 0.1 6.3e-11 42.8 0.1 1.9 1 0 0 1 1 1 1 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase Toprim PF01751.22 ETO35265.1 - 1.8e-07 31.3 0.0 1.8e-07 31.3 0.0 3.0 4 0 0 4 4 4 1 Toprim domain SapB_1 PF05184.15 ETO35265.1 - 0.18 11.9 1.8 18 5.5 0.0 3.8 3 0 0 3 3 3 0 Saposin-like type B, region 1 Actin PF00022.19 ETO35266.1 - 4e-08 32.3 0.0 4.8e-08 32.0 0.0 1.1 1 0 0 1 1 1 1 Actin GTP_EFTU_D4 PF14578.6 ETO35266.1 - 0.0038 17.1 0.1 0.039 13.8 0.0 2.1 2 0 0 2 2 2 1 Elongation factor Tu domain 4 PUB PF09409.10 ETO35268.1 - 0.37 10.8 3.4 1.7 8.6 1.4 2.6 2 1 0 2 2 2 0 PUB domain Kelch_2 PF07646.15 ETO35269.1 - 0.061 13.3 0.0 0.18 11.9 0.0 1.8 1 0 0 1 1 1 0 Kelch motif SPATA6 PF14909.6 ETO35269.1 - 0.097 12.8 1.2 18 5.5 0.1 2.5 2 0 0 2 2 2 0 Spermatogenesis-assoc protein 6 Anophelin PF10731.9 ETO35269.1 - 0.14 12.0 0.2 0.42 10.5 0.2 1.8 1 0 0 1 1 1 0 Thrombin inhibitor from mosquito DUF2457 PF10446.9 ETO35270.1 - 0.0012 18.1 20.7 0.0017 17.6 20.7 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) Nop14 PF04147.12 ETO35270.1 - 0.13 10.5 26.1 0.18 10.0 26.1 1.2 1 0 0 1 1 1 0 Nop14-like family DUF2730 PF10805.8 ETO35270.1 - 0.28 11.3 2.5 0.28 11.3 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF2730) NOA36 PF06524.12 ETO35270.1 - 0.79 9.0 21.8 0.046 13.1 16.6 1.6 2 0 0 2 2 2 0 NOA36 protein DNA_pol_phi PF04931.13 ETO35270.1 - 0.86 7.6 26.4 1.3 7.0 26.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi CDC45 PF02724.14 ETO35270.1 - 1.2 7.3 24.5 1.7 6.8 24.5 1.1 1 0 0 1 1 1 0 CDC45-like protein SID-1_RNA_chan PF13965.6 ETO35270.1 - 2.5 6.4 6.0 3.1 6.1 6.0 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DNA_ligase_A_N PF04675.14 ETO35270.1 - 2.7 8.3 8.6 0.78 10.0 5.0 1.9 3 0 0 3 3 3 0 DNA ligase N terminus LAP1C PF05609.12 ETO35270.1 - 3.2 6.7 20.4 4.7 6.2 20.4 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) Gti1_Pac2 PF09729.9 ETO35270.1 - 3.5 7.7 16.6 6.8 6.8 16.6 1.5 1 0 0 1 1 1 0 Gti1/Pac2 family Roughex PF06020.11 ETO35270.1 - 6.2 5.8 13.8 9.6 5.2 13.8 1.2 1 0 0 1 1 1 0 Drosophila roughex protein DUF202 PF02656.15 ETO35271.1 - 0.00067 20.1 0.3 0.0013 19.1 0.3 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF202) DUF2533 PF10752.9 ETO35272.1 - 1.2 9.6 5.4 9.2 6.8 0.4 3.0 1 1 2 3 3 3 0 Protein of unknown function (DUF2533) WD40 PF00400.32 ETO35274.1 - 2.7e-06 28.0 4.4 0.0022 18.8 0.3 3.8 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35274.1 - 0.0092 14.7 0.5 1.9 7.0 0.1 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 DUF4888 PF16229.5 ETO35274.1 - 0.029 14.3 0.4 0.041 13.8 0.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4888) AAA_22 PF13401.6 ETO35275.1 - 0.012 15.9 0.2 0.04 14.2 0.1 2.0 1 1 1 2 2 2 0 AAA domain Zeta_toxin PF06414.12 ETO35275.1 - 0.026 13.8 0.0 0.048 12.9 0.0 1.4 1 0 0 1 1 1 0 Zeta toxin TsaE PF02367.17 ETO35275.1 - 0.061 13.3 0.1 0.46 10.5 0.0 2.1 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE NACHT PF05729.12 ETO35275.1 - 0.09 12.7 0.0 0.21 11.5 0.0 1.7 1 0 0 1 1 1 0 NACHT domain RsgA_GTPase PF03193.16 ETO35275.1 - 0.12 12.3 0.0 0.19 11.6 0.0 1.4 1 0 0 1 1 1 0 RsgA GTPase AAA_29 PF13555.6 ETO35275.1 - 0.13 12.0 0.0 0.26 11.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_18 PF13238.6 ETO35275.1 - 0.18 12.3 1.5 0.34 11.5 0.0 2.2 3 0 0 3 3 3 0 AAA domain zf-Mss51 PF13824.6 ETO35276.1 - 0.015 15.4 1.4 0.028 14.5 0.4 1.9 1 1 1 2 2 2 0 Zinc-finger of mitochondrial splicing suppressor 51 DNA_ligase_ZBD PF03119.16 ETO35276.1 - 0.028 14.4 1.4 1 9.4 0.1 2.4 2 0 0 2 2 2 0 NAD-dependent DNA ligase C4 zinc finger domain bZIP_C PF12498.8 ETO35276.1 - 0.075 14.0 0.0 0.14 13.1 0.0 1.4 1 0 0 1 1 1 0 Basic leucine-zipper C terminal Pombe_5TM PF09437.10 ETO35278.1 - 0.4 10.3 10.9 0.033 13.9 2.2 2.7 2 1 1 3 3 3 0 Pombe specific 5TM protein WD40 PF00400.32 ETO35279.1 - 0.095 13.6 0.1 0.33 11.9 0.0 1.9 2 0 0 2 2 2 0 WD domain, G-beta repeat zf-C2H2_7 PF15269.6 ETO35280.1 - 0.18 11.9 2.6 12 6.1 0.6 2.7 1 1 1 2 2 2 0 Zinc-finger WD40 PF00400.32 ETO35283.1 - 4.4e-12 46.3 7.9 0.00012 22.8 0.1 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35283.1 - 0.0028 17.9 0.0 0.41 11.0 0.0 2.6 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35283.1 - 0.0039 16.6 9.8 0.014 14.7 2.0 2.3 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO35283.1 - 0.074 11.7 1.5 3.1 6.3 0.0 2.8 2 1 0 3 3 3 0 Nucleoporin Nup120/160 Acyl_transf_1 PF00698.21 ETO35283.1 - 0.094 12.2 0.0 0.15 11.5 0.0 1.3 1 1 0 1 1 1 0 Acyl transferase domain WD40 PF00400.32 ETO35285.1 - 2.9e-64 211.5 21.6 7.5e-09 36.1 0.0 7.5 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35285.1 - 9.2e-28 96.4 3.8 7.4e-08 32.6 0.1 6.1 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35285.1 - 7.1e-17 61.4 0.6 0.00087 18.3 0.0 6.2 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35285.1 - 4.3e-14 52.5 1.0 0.0011 18.3 0.0 4.3 1 1 3 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO35285.1 - 5e-09 35.3 4.2 0.52 8.9 0.1 5.3 2 1 3 5 5 5 4 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO35285.1 - 8.1e-07 27.9 0.3 0.00071 18.2 0.1 2.6 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO35285.1 - 1.8e-06 27.7 3.5 5.5 7.1 0.0 6.2 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO35285.1 - 0.0026 16.5 8.3 0.49 9.1 0.1 4.7 1 1 3 4 4 4 2 Nup133 N terminal like VID27 PF08553.10 ETO35285.1 - 0.004 16.3 0.0 0.13 11.3 0.0 2.7 2 1 1 3 3 3 1 VID27 C-terminal WD40-like domain DUF727 PF05303.12 ETO35285.1 - 0.0068 16.5 0.9 9.8 6.3 0.0 3.6 3 1 0 4 4 3 1 Protein of unknown function (DUF727) DPPIV_N PF00930.21 ETO35285.1 - 0.0073 15.1 0.1 11 4.6 0.0 3.9 1 1 3 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region BBS2_Mid PF14783.6 ETO35285.1 - 0.032 14.3 2.1 19 5.3 0.0 4.9 4 2 1 5 5 5 0 Ciliary BBSome complex subunit 2, middle region Nbas_N PF15492.6 ETO35285.1 - 0.033 13.5 0.6 12 5.1 0.0 3.2 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DUF4072 PF13284.6 ETO35285.1 - 0.18 12.3 0.0 39 4.8 0.0 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4072) Proteasome_A_N PF10584.9 ETO35285.1 - 0.2 11.4 2.0 1e+02 2.7 0.0 4.3 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature PDEase_I PF00233.19 ETO35286.1 - 1.3e-42 146.2 0.0 4.6e-40 137.8 0.0 2.6 2 0 0 2 2 2 2 3'5'-cyclic nucleotide phosphodiesterase Methyltransf_32 PF13679.6 ETO35286.1 - 0.0099 15.9 1.3 0.0099 15.9 1.3 1.8 2 0 0 2 2 2 1 Methyltransferase domain DUF2057 PF09829.9 ETO35286.1 - 0.39 10.8 11.8 0.19 11.9 1.7 2.5 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2057) FSA_C PF10479.9 ETO35286.1 - 0.47 8.5 15.8 0.13 10.4 5.6 2.1 2 0 0 2 2 2 0 Fragile site-associated protein C-terminus DUF4050 PF13259.6 ETO35286.1 - 0.58 10.4 7.4 1.1 9.5 0.5 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) RNA_pol_Rpc4 PF05132.14 ETO35286.1 - 1.3 9.4 6.2 2.4 8.6 0.1 2.6 3 0 0 3 3 3 0 RNA polymerase III RPC4 Striatin PF08232.12 ETO35286.1 - 1.8 9.1 10.9 1.1 9.8 1.9 2.4 2 0 0 2 2 2 0 Striatin family Kinesin_assoc PF16183.5 ETO35286.1 - 1.8 8.6 8.1 9.2 6.4 2.8 2.4 2 0 0 2 2 2 0 Kinesin-associated Alpha_GJ PF03229.13 ETO35286.1 - 1.9 9.1 17.7 2.1 8.9 6.4 2.5 2 0 0 2 2 2 0 Alphavirus glycoprotein J Presenilin PF01080.17 ETO35286.1 - 3.5 6.3 7.5 2.7 6.7 1.4 2.2 2 0 0 2 2 2 0 Presenilin ASD2 PF08687.11 ETO35286.1 - 6.1 6.3 9.2 13 5.2 3.6 2.2 2 0 0 2 2 2 0 Apx/Shroom domain ASD2 Apolipoprotein PF01442.18 ETO35287.1 - 0.0057 16.6 30.7 0.1 12.5 9.6 2.5 2 1 0 2 2 2 2 Apolipoprotein A1/A4/E domain TolA_bind_tri PF16331.5 ETO35287.1 - 0.021 14.9 5.6 0.021 14.9 5.6 5.1 4 2 1 5 5 4 0 TolA binding protein trimerisation DUF4407 PF14362.6 ETO35287.1 - 0.029 13.7 31.5 0.37 10.1 4.4 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 ETO35287.1 - 0.037 14.4 4.1 0.037 14.4 4.1 5.7 3 3 3 6 6 6 0 Flagella accessory protein C (FlaC) DUF1640 PF07798.11 ETO35287.1 - 0.57 10.2 48.6 1.5 8.8 1.9 3.6 1 1 3 4 4 4 0 Protein of unknown function (DUF1640) Baculo_PEP_C PF04513.12 ETO35287.1 - 0.93 9.5 19.3 0.9 9.6 2.0 4.0 2 1 2 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus Golgin_A5 PF09787.9 ETO35287.1 - 1.2 8.5 57.1 0.013 15.0 25.0 2.8 1 1 2 3 3 3 0 Golgin subfamily A member 5 ECH_1 PF00378.20 ETO35287.1 - 2.5 7.3 13.2 0.41 9.9 3.8 2.7 2 1 0 2 2 2 0 Enoyl-CoA hydratase/isomerase Phasin PF05597.11 ETO35287.1 - 5.5 7.0 22.6 0.24 11.4 4.9 4.0 2 1 1 3 3 3 0 Poly(hydroxyalcanoate) granule associated protein (phasin) IMPa_helical PF18642.1 ETO35287.1 - 5.9 7.4 17.7 0.99 9.8 3.0 3.9 2 2 1 4 4 4 0 Immunomodulating metalloprotease helical domain GvpL_GvpF PF06386.11 ETO35287.1 - 7 6.5 23.4 6 6.7 6.3 2.6 1 1 2 3 3 3 0 Gas vesicle synthesis protein GvpL/GvpF Paramyxo_ncap PF00973.19 ETO35288.1 - 3 6.7 10.6 4.4 6.1 10.6 1.2 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein PhaP_Bmeg PF09602.10 ETO35289.1 - 0.0007 19.6 3.8 0.00087 19.3 3.8 1.1 1 0 0 1 1 1 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) DUF1803 PF08820.10 ETO35289.1 - 0.017 15.1 1.5 0.022 14.8 1.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1803) Rota_NSP4 PF01452.16 ETO35289.1 - 0.02 14.5 2.6 0.023 14.4 2.1 1.3 1 1 0 1 1 1 0 Rotavirus non structural protein WD40 PF00400.32 ETO35290.1 - 1.3e-30 104.9 21.0 3.1e-07 31.0 0.4 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35290.1 - 5e-09 36.3 2.4 0.31 11.4 0.0 5.4 3 1 2 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain TMP_2 PF06791.13 ETO35290.1 - 0.059 13.0 0.2 0.19 11.4 0.0 1.8 1 1 0 1 1 1 0 Prophage tail length tape measure protein FAM76 PF16046.5 ETO35290.1 - 0.069 12.5 32.5 0.24 10.7 32.5 1.9 1 1 0 1 1 1 0 FAM76 protein zf-RING_2 PF13639.6 ETO35290.1 - 0.12 12.7 0.6 0.59 10.5 0.6 2.3 1 1 0 1 1 1 0 Ring finger domain DUF4407 PF14362.6 ETO35290.1 - 0.13 11.6 9.3 0.21 10.9 9.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) YjcZ PF13990.6 ETO35290.1 - 0.14 11.6 7.2 0.22 10.9 7.2 1.2 1 0 0 1 1 1 0 YjcZ-like protein CC2-LZ PF16516.5 ETO35290.1 - 0.14 12.6 17.6 0.062 13.7 13.5 2.6 1 1 1 2 2 2 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator DUF848 PF05852.11 ETO35290.1 - 0.18 11.9 15.1 0.31 11.1 10.9 2.6 1 1 2 3 3 3 0 Gammaherpesvirus protein of unknown function (DUF848) Baculo_PEP_C PF04513.12 ETO35290.1 - 1.4 9.0 18.0 0.11 12.6 7.4 2.4 1 1 1 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus YabA PF06156.13 ETO35290.1 - 4.8 7.9 21.9 0.32 11.7 7.0 3.1 2 1 1 3 3 2 0 Initiation control protein YabA CENP-H PF05837.12 ETO35290.1 - 4.9 7.6 23.0 2 8.9 10.9 3.2 1 1 2 3 3 3 0 Centromere protein H (CENP-H) Tropomyosin_1 PF12718.7 ETO35290.1 - 6.6 6.9 23.0 0.43 10.7 14.5 2.9 1 1 2 3 3 3 0 Tropomyosin like Laminin_II PF06009.12 ETO35290.1 - 9.6 6.2 16.2 14 5.7 4.1 2.3 1 1 1 2 2 2 0 Laminin Domain II eRF1_1 PF03463.15 ETO35291.1 - 1.4e-05 25.1 0.3 2.2e-05 24.4 0.3 1.4 1 0 0 1 1 1 1 eRF1 domain 1 Agarase_CBM PF17992.1 ETO35291.1 - 0.016 14.8 0.3 2.7 7.5 0.2 2.2 1 1 1 2 2 2 0 Agarase CBM like domain Snf7 PF03357.21 ETO35292.1 - 4.6e-23 81.7 14.0 4.6e-23 81.7 14.0 2.1 2 0 0 2 2 2 1 Snf7 HisKA PF00512.25 ETO35292.1 - 0.29 11.2 2.6 0.54 10.3 1.2 2.2 1 1 1 2 2 2 0 His Kinase A (phospho-acceptor) domain RhoGAP PF00620.27 ETO35294.1 - 5.6e-07 29.5 2.2 3.9e-05 23.5 2.2 2.6 1 1 0 1 1 1 1 RhoGAP domain Cwf_Cwc_15 PF04889.12 ETO35294.1 - 0.0011 18.8 5.2 0.0011 18.8 5.2 3.2 3 0 0 3 3 3 2 Cwf15/Cwc15 cell cycle control protein DUF1754 PF08555.10 ETO35294.1 - 0.007 17.1 5.1 0.007 17.1 5.1 3.6 4 0 0 4 4 4 1 Eukaryotic family of unknown function (DUF1754) RXT2_N PF08595.11 ETO35294.1 - 2.2 8.3 28.9 0.87 9.6 3.1 3.5 3 0 0 3 3 3 0 RXT2-like, N-terminal Sigma70_ner PF04546.13 ETO35294.1 - 8.4 6.2 20.9 0.72 9.7 1.0 3.4 2 1 1 3 3 3 0 Sigma-70, non-essential region Holin_BhlA PF10960.8 ETO35295.1 - 0.013 15.5 0.4 0.043 13.8 0.0 2.0 1 1 1 2 2 2 0 BhlA holin family DUF3784 PF12650.7 ETO35295.1 - 0.14 12.4 5.4 0.37 11.0 0.3 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF3784) WD40 PF00400.32 ETO35296.1 - 3.2e-05 24.6 0.7 0.00045 21.0 0.0 2.9 3 0 0 3 3 3 1 WD domain, G-beta repeat Y_phosphatase PF00102.27 ETO35297.1 - 1.1e-10 41.4 0.1 1.7e-10 40.8 0.1 1.2 1 0 0 1 1 1 1 Protein-tyrosine phosphatase DSPc PF00782.20 ETO35297.1 - 6.5e-08 32.5 0.0 1.2e-07 31.6 0.0 1.4 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain CDKN3 PF05706.12 ETO35297.1 - 0.00078 19.2 0.1 0.0015 18.2 0.1 1.5 1 0 0 1 1 1 1 Cyclin-dependent kinase inhibitor 3 (CDKN3) Y_phosphatase2 PF03162.13 ETO35297.1 - 0.0012 18.4 0.1 0.0019 17.8 0.1 1.3 1 0 0 1 1 1 1 Tyrosine phosphatase family Y_phosphatase3 PF13350.6 ETO35297.1 - 0.013 15.5 0.0 0.02 14.9 0.0 1.3 1 0 0 1 1 1 0 Tyrosine phosphatase family PTPlike_phytase PF14566.6 ETO35297.1 - 0.014 15.5 0.0 0.021 14.9 0.0 1.3 1 0 0 1 1 1 0 Inositol hexakisphosphate UQ_con PF00179.26 ETO35298.1 - 4.2e-32 110.7 0.5 1.2e-31 109.3 0.0 1.8 2 0 0 2 2 2 1 Ubiquitin-conjugating enzyme PET117 PF15786.5 ETO35298.1 - 0.031 14.5 1.8 0.06 13.6 1.8 1.5 1 0 0 1 1 1 0 PET assembly of cytochrome c oxidase, mitochondrial Ins145_P3_rec PF08709.11 ETO35298.1 - 0.075 12.2 0.8 0.11 11.6 0.8 1.3 1 0 0 1 1 1 0 Inositol 1,4,5-trisphosphate/ryanodine receptor Kei1 PF08552.11 ETO35298.1 - 0.19 11.6 0.8 0.27 11.1 0.8 1.1 1 0 0 1 1 1 0 Inositolphosphorylceramide synthase subunit Kei1 Folate_carrier PF01770.18 ETO35298.1 - 0.6 8.8 1.4 0.8 8.4 1.4 1.1 1 0 0 1 1 1 0 Reduced folate carrier O-antigen_lig PF13425.6 ETO35298.1 - 5.3 5.7 4.8 6.9 5.3 4.8 1.1 1 0 0 1 1 1 0 O-antigen ligase like membrane protein DEP PF00610.21 ETO35299.1 - 3.2e-06 27.1 0.4 1.2e-05 25.3 0.0 2.1 2 0 0 2 2 2 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Csc2 PF18320.1 ETO35299.1 - 0.0055 15.7 0.4 0.0092 15.0 0.4 1.3 1 0 0 1 1 1 1 Csc2 Crispr SepSecS PF05889.13 ETO35300.1 - 1.9e-13 49.9 0.0 4.4e-13 48.7 0.0 1.5 2 0 0 2 2 2 1 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Rad21_Rec8_N PF04825.13 ETO35300.1 - 0.068 13.3 0.1 0.14 12.4 0.1 1.5 2 0 0 2 2 2 0 N terminus of Rad21 / Rec8 like protein ProRS-C_2 PF09181.10 ETO35300.1 - 0.19 11.8 2.5 1 9.5 0.3 2.3 2 0 0 2 2 2 0 Prolyl-tRNA synthetase, C-terminal ART PF01129.18 ETO35303.1 - 0.00022 20.6 1.0 0.00022 20.6 1.0 2.0 2 0 0 2 2 2 1 NAD:arginine ADP-ribosyltransferase PUB PF09409.10 ETO35304.1 - 7.2e-06 25.8 0.7 3.1e-05 23.8 0.3 2.3 2 0 0 2 2 2 1 PUB domain DUF2175 PF09943.9 ETO35305.1 - 0.053 13.8 0.1 3.1 8.2 0.0 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2175) DUF3768 PF12599.8 ETO35306.1 - 0.045 13.8 0.4 3.6 7.6 0.2 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3768) PUB PF09409.10 ETO35307.1 - 0.057 13.4 2.4 0.11 12.5 1.6 2.0 1 1 0 1 1 1 0 PUB domain Gly_radical PF01228.21 ETO35308.1 - 0.098 13.2 0.1 0.098 13.2 0.1 1.1 1 0 0 1 1 1 0 Glycine radical DUF4524 PF15025.6 ETO35309.1 - 5.1e-07 29.5 0.0 1e-06 28.5 0.0 1.5 1 0 0 1 1 1 1 Domain of unknown function (DUF4524) POLO_box PF00659.18 ETO35309.1 - 0.026 14.7 0.5 3.6 7.9 0.1 2.7 2 0 0 2 2 2 0 POLO box duplicated region Tubulin PF00091.25 ETO35310.1 - 1.1e-29 104.0 0.0 4.8e-29 102.0 0.0 1.8 2 0 0 2 2 2 1 Tubulin/FtsZ family, GTPase domain RTC4 PF14474.6 ETO35310.1 - 0.021 15.0 0.1 3.1 8.0 0.0 2.4 2 0 0 2 2 2 0 RTC4-like domain SSPI PF14098.6 ETO35310.1 - 0.17 12.1 3.0 0.59 10.3 0.7 2.5 2 0 0 2 2 2 0 Small, acid-soluble spore protein I DUF2552 PF10827.8 ETO35312.1 - 0.074 13.2 0.0 5 7.4 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2552) Tim54 PF11711.8 ETO35314.1 - 0.075 11.8 9.6 0.1 11.4 9.6 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 CNDH2_C PF16858.5 ETO35314.1 - 3.9 7.3 19.6 5.2 6.9 19.6 1.1 1 0 0 1 1 1 0 Condensin II complex subunit CAP-H2 or CNDH2, C-term Nop14 PF04147.12 ETO35314.1 - 6.9 4.7 33.1 7.6 4.6 33.1 1.0 1 0 0 1 1 1 0 Nop14-like family SDA1 PF05285.12 ETO35314.1 - 7.5 5.9 31.4 9.9 5.5 31.4 1.2 1 0 0 1 1 1 0 SDA1 DNA_pol_phi PF04931.13 ETO35314.1 - 8.4 4.4 30.2 11 4.0 30.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ETO35317.1 - 2.4e-24 85.1 15.8 1.4e-06 28.9 0.6 5.8 4 2 1 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35317.1 - 1.7e-08 34.7 0.3 0.00066 19.9 0.0 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35317.1 - 0.00013 20.8 0.0 2.9 6.4 0.0 3.1 3 0 0 3 3 3 3 Nucleoporin Nup120/160 DUF1968 PF09291.10 ETO35318.1 - 0.39 10.8 6.9 0.065 13.3 1.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF1968) PRP1_N PF06424.12 ETO35318.1 - 0.8 10.1 4.4 2.2 8.7 0.0 2.7 2 1 1 3 3 3 0 PRP1 splicing factor, N-terminal TipAS PF07739.13 ETO35318.1 - 2.3 8.8 6.2 0.48 11.0 1.9 2.2 2 1 0 2 2 2 0 TipAS antibiotic-recognition domain Bud13 PF09736.9 ETO35318.1 - 7.1 7.0 10.3 54 4.2 10.3 2.2 1 1 0 1 1 1 0 Pre-mRNA-splicing factor of RES complex Couple_hipA PF13657.6 ETO35319.1 - 5.5e-08 33.4 0.0 1.5e-07 31.9 0.0 1.8 1 0 0 1 1 1 1 HipA N-terminal domain HTH_3 PF01381.22 ETO35319.1 - 3.2e-06 27.1 0.0 9.3e-06 25.6 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix HTH_19 PF12844.7 ETO35319.1 - 2e-05 24.5 0.3 0.00057 19.8 0.0 3.2 3 0 0 3 3 3 1 Helix-turn-helix domain HTH_37 PF13744.6 ETO35319.1 - 9.2e-05 22.3 0.0 0.00031 20.6 0.0 1.9 1 0 0 1 1 1 1 Helix-turn-helix domain HTH_31 PF13560.6 ETO35319.1 - 0.00074 19.8 0.0 0.0013 19.0 0.0 1.3 1 0 0 1 1 1 1 Helix-turn-helix domain MqsA_antitoxin PF15731.5 ETO35319.1 - 0.0023 18.1 0.0 0.016 15.3 0.0 2.3 2 0 0 2 2 2 1 Antitoxin component of bacterial toxin-antitoxin system, MqsA HTH_25 PF13413.6 ETO35319.1 - 0.028 14.3 0.0 0.094 12.6 0.0 1.9 1 1 0 1 1 1 0 Helix-turn-helix domain 2OG-FeII_Oxy_3 PF13640.6 ETO35320.1 - 0.0052 17.7 0.0 0.0083 17.0 0.0 1.3 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily Adeno_100 PF02438.16 ETO35320.1 - 0.015 13.5 0.0 0.019 13.2 0.0 1.1 1 0 0 1 1 1 0 Late 100kD protein TPR_12 PF13424.6 ETO35322.1 - 4.9e-17 62.0 1.4 2.5e-10 40.5 0.1 2.0 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35322.1 - 2.2e-08 33.6 9.6 0.00048 19.8 0.3 2.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35322.1 - 5.2e-07 29.3 0.0 0.0008 19.2 0.0 2.3 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35322.1 - 7.3e-07 28.8 3.7 0.015 15.4 0.8 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35322.1 - 2.2e-06 27.3 0.2 0.043 13.8 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35322.1 - 6.2e-05 22.9 10.1 0.014 15.6 0.5 2.7 3 0 0 3 3 3 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO35322.1 - 0.0019 18.4 0.8 0.0027 17.9 0.8 1.3 1 0 0 1 1 1 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO35322.1 - 0.02 14.9 5.4 0.49 10.5 1.4 2.3 2 0 0 2 2 2 0 Tetratricopeptide repeat Fucose_iso_N2 PF07882.12 ETO35322.1 - 0.068 12.7 0.2 0.14 11.7 0.1 1.6 1 1 1 2 2 2 0 L-fucose isomerase, second N-terminal domain TPR_16 PF13432.6 ETO35322.1 - 0.076 13.7 0.0 2 9.1 0.0 2.1 1 1 1 2 2 2 0 Tetratricopeptide repeat Pep3_Vps18 PF05131.14 ETO35322.1 - 0.078 12.8 0.8 3.1 7.6 0.2 2.1 1 1 1 2 2 2 0 Pep3/Vps18/deep orange family TPR_17 PF13431.6 ETO35322.1 - 0.088 13.2 3.5 0.93 10.0 2.4 2.7 2 1 0 2 2 2 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35322.1 - 0.57 9.9 4.9 9.7 6.0 0.2 2.7 3 1 0 3 3 3 0 TPR repeat Laminin_G_3 PF13385.6 ETO35324.1 - 1.8e-12 47.6 0.0 3.8e-12 46.6 0.0 1.5 1 0 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Laminin_G_2 PF02210.24 ETO35324.1 - 0.0052 17.4 0.1 0.021 15.4 0.0 2.0 2 0 0 2 2 2 1 Laminin G domain DUF3782 PF12644.7 ETO35325.1 - 0.11 12.6 0.2 0.61 10.3 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF3782) RNB PF00773.19 ETO35326.1 - 1.2e-17 64.3 0.0 2.4e-17 63.3 0.0 1.5 1 0 0 1 1 1 1 RNB domain OB_Dis3 PF17849.1 ETO35326.1 - 4.9e-06 26.5 0.0 9.1e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 Dis3-like cold-shock domain 2 (CSD2) DUF4246 PF14033.6 ETO35327.1 - 3e-08 33.2 0.2 0.00027 20.2 0.1 2.0 1 1 1 2 2 2 2 Protein of unknown function (DUF4246) Beta_helix PF13229.6 ETO35330.1 - 2e-05 24.5 4.0 0.00051 19.9 1.1 2.3 2 0 0 2 2 2 2 Right handed beta helix region PPR_2 PF13041.6 ETO35331.1 - 4.8e-14 52.3 2.5 6.9e-10 39.0 0.3 3.4 2 1 1 3 3 3 3 PPR repeat family PPR_1 PF12854.7 ETO35331.1 - 1.3e-12 47.2 2.2 3.2e-06 26.7 0.0 3.3 3 0 0 3 3 3 3 PPR repeat PPR_3 PF13812.6 ETO35331.1 - 2.5e-12 46.7 1.9 7e-05 22.8 0.0 3.4 2 1 1 3 3 3 3 Pentatricopeptide repeat domain PPR PF01535.20 ETO35331.1 - 8.4e-12 44.5 0.9 9.9e-06 25.5 0.0 3.0 3 0 0 3 3 3 2 PPR repeat PPR_long PF17177.4 ETO35331.1 - 3.1e-06 26.7 0.0 4.3e-06 26.2 0.0 1.3 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP ATP13 PF12921.7 ETO35331.1 - 0.021 14.7 0.3 0.044 13.6 0.3 1.6 1 1 0 1 1 1 0 Mitochondrial ATPase expression Secretin_N_2 PF07655.13 ETO35332.1 - 0.047 14.2 12.7 2.6 8.6 8.7 2.4 2 0 0 2 2 2 0 Secretin N-terminal domain RPOL_N PF14700.6 ETO35332.1 - 0.21 11.0 0.0 0.21 11.0 0.0 2.2 2 0 0 2 2 2 0 DNA-directed RNA polymerase N-terminal PDDEXK_6 PF04720.12 ETO35332.1 - 5.5 6.9 13.8 20 5.0 8.8 2.2 2 0 0 2 2 2 0 PDDEXK-like family of unknown function Apis_Csd PF11671.8 ETO35332.1 - 7.3 6.6 28.2 2.4 8.2 5.9 2.6 2 0 0 2 2 2 0 Complementary sex determiner protein DHC_N1 PF08385.12 ETO35333.1 - 3.6e-14 52.3 1.4 3.6e-14 52.3 1.4 2.1 2 0 0 2 2 2 1 Dynein heavy chain, N-terminal region 1 DUF3657 PF12394.8 ETO35333.1 - 1.4 9.5 3.9 44 4.7 0.9 3.7 4 0 0 4 4 4 0 Protein FAM135 CAP59_mtransfer PF11735.8 ETO35333.1 - 1.7 8.3 6.4 1.8 8.2 3.5 2.2 1 1 0 2 2 2 0 Cryptococcal mannosyltransferase 1 Presenilin PF01080.17 ETO35333.1 - 2.3 6.9 11.3 4.3 6.0 11.3 1.4 1 0 0 1 1 1 0 Presenilin DUF2203 PF09969.9 ETO35333.1 - 6.1 7.6 16.4 1.5 9.6 6.1 3.3 2 1 0 3 3 3 0 Uncharacterized conserved protein (DUF2203) EMC3_TMCO1 PF01956.16 ETO35333.1 - 6.7 6.4 11.6 6.5 6.5 5.0 2.5 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like Vps39_2 PF10367.9 ETO35333.1 - 9.2 6.8 12.2 8.2 6.9 5.8 3.1 2 1 1 3 3 3 0 Vacuolar sorting protein 39 domain 2 DUF1917 PF08939.10 ETO35333.1 - 9.4 6.0 18.7 0.23 11.3 2.2 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF1917) DHC_N1 PF08385.12 ETO35334.1 - 7.2e-41 140.5 8.4 7.2e-41 140.5 8.4 3.2 3 1 1 4 4 4 1 Dynein heavy chain, N-terminal region 1 DHC_N2 PF08393.13 ETO35334.1 - 7.6e-09 35.2 1.6 7.6e-09 35.2 1.6 4.7 4 2 0 4 4 4 1 Dynein heavy chain, N-terminal region 2 RPW8 PF05659.11 ETO35334.1 - 0.00073 19.2 13.3 0.062 13.0 1.0 5.2 4 0 0 4 4 4 2 Arabidopsis broad-spectrum mildew resistance protein RPW8 SAM_PNT PF02198.16 ETO35334.1 - 0.016 15.2 0.2 0.055 13.4 0.2 2.0 1 0 0 1 1 1 0 Sterile alpha motif (SAM)/Pointed domain DUF4259 PF14078.6 ETO35334.1 - 2.4 8.9 10.0 8.4 7.2 0.1 3.9 4 0 0 4 4 4 0 Domain of unknown function (DUF4259) MbeD_MobD PF04899.12 ETO35334.1 - 3.6 7.8 5.9 6.8 6.9 0.1 4.3 3 1 1 4 4 4 0 MbeD/MobD like AAA_6 PF12774.7 ETO35335.1 - 1.4e-112 375.9 0.1 5.3e-79 265.6 0.0 4.6 3 1 1 4 4 4 2 Hydrolytic ATP binding site of dynein motor region DHC_N2 PF08393.13 ETO35335.1 - 5e-78 262.9 7.4 5e-78 262.9 7.4 1.9 2 0 0 2 2 1 1 Dynein heavy chain, N-terminal region 2 AAA_8 PF12780.7 ETO35335.1 - 8.7e-45 153.1 0.0 1.4e-43 149.1 0.1 2.9 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 AAA_7 PF12775.7 ETO35335.1 - 1.1e-41 142.4 0.0 3.6e-34 117.9 0.0 5.0 5 0 0 5 5 5 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO35335.1 - 2.4e-30 105.3 0.0 4e-12 46.3 0.0 5.6 4 1 0 4 4 4 4 AAA domain (dynein-related subfamily) Dynein_AAA_lid PF17852.1 ETO35335.1 - 8.4e-17 61.5 0.2 4.3e-16 59.2 0.0 2.5 2 0 0 2 2 1 1 Dynein heavy chain AAA lid domain AAA PF00004.29 ETO35335.1 - 3.3e-15 56.7 0.0 0.012 16.0 0.0 5.8 5 1 0 5 5 4 3 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO35335.1 - 8.2e-14 52.0 0.0 0.002 18.4 0.0 5.6 5 0 0 5 5 4 3 AAA domain AAA_16 PF13191.6 ETO35335.1 - 1.7e-11 44.8 0.1 0.55 10.6 0.0 4.9 4 0 0 4 4 4 4 AAA ATPase domain AAA_33 PF13671.6 ETO35335.1 - 2.4e-10 40.7 0.1 0.027 14.6 0.0 4.9 4 0 0 4 4 4 3 AAA domain AAA_18 PF13238.6 ETO35335.1 - 8.7e-09 36.0 0.0 1.4 9.5 0.0 5.5 4 0 0 4 4 4 1 AAA domain IstB_IS21 PF01695.17 ETO35335.1 - 3.5e-07 30.1 0.3 0.046 13.5 0.0 4.5 4 0 0 4 4 4 2 IstB-like ATP binding protein ABC_tran PF00005.27 ETO35335.1 - 1.6e-06 28.7 0.8 1.3 9.5 0.0 4.8 5 0 0 5 5 4 2 ABC transporter RNA_helicase PF00910.22 ETO35335.1 - 5.7e-06 26.7 0.0 3 8.3 0.0 4.7 4 0 0 4 4 4 1 RNA helicase AAA_30 PF13604.6 ETO35335.1 - 8.5e-06 25.6 0.2 2.6 7.7 0.0 4.3 4 0 0 4 4 4 1 AAA domain AAA_29 PF13555.6 ETO35335.1 - 9.5e-06 25.3 0.1 2.8 7.7 0.0 4.1 3 0 0 3 3 3 1 P-loop containing region of AAA domain T2SSE PF00437.20 ETO35335.1 - 1.2e-05 24.6 0.3 0.018 14.1 0.0 3.6 4 0 0 4 4 3 1 Type II/IV secretion system protein RsgA_GTPase PF03193.16 ETO35335.1 - 2.2e-05 24.4 0.0 2.1 8.2 0.0 3.6 3 0 0 3 3 3 1 RsgA GTPase FtsK_SpoIIIE PF01580.18 ETO35335.1 - 6.1e-05 22.5 0.0 0.12 11.7 0.0 3.4 3 0 0 3 3 3 1 FtsK/SpoIIIE family AAA_25 PF13481.6 ETO35335.1 - 7.3e-05 22.4 0.4 0.1 12.1 0.0 4.5 4 1 0 4 4 4 1 AAA domain Mg_chelatase PF01078.21 ETO35335.1 - 0.00017 21.1 0.4 0.99 8.8 0.0 4.7 5 0 0 5 5 5 1 Magnesium chelatase, subunit ChlI Sigma54_activat PF00158.26 ETO35335.1 - 0.00018 21.3 0.0 8.2 6.1 0.0 3.7 3 0 0 3 3 3 0 Sigma-54 interaction domain Guanylate_kin PF00625.21 ETO35335.1 - 0.00023 20.9 0.1 0.024 14.3 0.0 3.2 3 0 0 3 3 3 1 Guanylate kinase AAA_24 PF13479.6 ETO35335.1 - 0.00064 19.5 0.0 14 5.4 0.0 4.7 4 0 0 4 4 4 0 AAA domain AAA_28 PF13521.6 ETO35335.1 - 0.00093 19.5 0.0 58 3.9 0.0 5.0 4 0 0 4 4 4 0 AAA domain AAA_19 PF13245.6 ETO35335.1 - 0.00096 19.5 1.1 0.85 9.9 0.0 4.4 5 0 0 5 5 4 1 AAA domain AAA_14 PF13173.6 ETO35335.1 - 0.0022 18.1 0.0 1.1 9.3 0.0 3.7 4 0 0 4 4 3 1 AAA domain Sigma54_activ_2 PF14532.6 ETO35335.1 - 0.0035 17.4 0.0 5.9 7.0 0.0 4.1 4 0 0 4 4 3 0 Sigma-54 interaction domain RuvB_N PF05496.12 ETO35335.1 - 0.0039 17.0 0.0 29 4.4 0.0 3.8 3 0 0 3 3 3 0 Holliday junction DNA helicase RuvB P-loop domain Rad17 PF03215.15 ETO35335.1 - 0.014 15.4 0.0 8.2 6.3 0.0 4.2 4 0 0 4 4 4 0 Rad17 P-loop domain Zeta_toxin PF06414.12 ETO35335.1 - 0.022 14.1 0.0 1.3 8.3 0.0 3.1 3 0 0 3 3 3 0 Zeta toxin Rsd_AlgQ PF04353.13 ETO35335.1 - 0.03 14.3 0.3 1 9.3 0.1 3.4 3 0 0 3 3 3 0 Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ AAA_11 PF13086.6 ETO35335.1 - 0.031 14.1 1.3 2.8 7.6 0.0 3.8 4 0 0 4 4 4 0 AAA domain NACHT PF05729.12 ETO35335.1 - 0.038 13.9 0.2 8.9 6.2 0.0 4.4 4 0 0 4 4 4 0 NACHT domain Gtr1_RagA PF04670.12 ETO35335.1 - 0.065 12.6 0.0 12 5.2 0.0 3.8 4 0 0 4 4 4 0 Gtr1/RagA G protein conserved region Roc PF08477.13 ETO35335.1 - 0.091 13.0 0.2 31 4.8 0.0 4.2 4 0 0 4 4 3 0 Ras of Complex, Roc, domain of DAPkinase Serpin PF00079.20 ETO35337.1 - 1.3e-22 80.6 1.0 1.3e-21 77.4 1.0 1.9 1 1 0 1 1 1 1 Serpin (serine protease inhibitor) DUF3139 PF11337.8 ETO35337.1 - 0.088 13.5 0.4 0.2 12.4 0.4 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3139) DDE_Tnp_1_2 PF13586.6 ETO35337.1 - 0.095 13.1 1.2 11 6.5 0.0 2.5 2 0 0 2 2 2 0 Transposase DDE domain DUF4337 PF14235.6 ETO35337.1 - 0.32 11.1 1.1 0.6 10.2 1.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4337) MRNIP PF15749.5 ETO35337.1 - 0.34 11.7 4.9 0.27 12.0 2.1 2.2 2 0 0 2 2 2 0 MRN-interacting protein DUF1840 PF08895.11 ETO35337.1 - 0.41 11.0 2.5 0.8 10.1 2.5 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1840) SPARC_Ca_bdg PF10591.9 ETO35337.1 - 0.61 10.4 5.1 10 6.5 0.9 3.1 3 0 0 3 3 3 0 Secreted protein acidic and rich in cysteine Ca binding region WD40 PF00400.32 ETO35339.1 - 1.1e-24 86.2 22.7 8.3e-06 26.5 0.5 6.5 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35339.1 - 5.5e-06 26.6 0.5 0.4 11.0 0.0 4.5 4 1 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35339.1 - 0.00066 18.4 8.7 0.0024 16.6 0.4 3.0 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF2603 PF10788.9 ETO35339.1 - 0.095 12.7 0.1 0.72 9.9 0.1 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2603) TetM_leader PF08076.11 ETO35339.1 - 7.4 6.5 6.1 3.5 7.5 0.2 3.4 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide DUF1201 PF06716.11 ETO35341.1 - 0.03 14.3 6.0 0.03 14.3 6.0 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1201) Holin_BhlA PF10960.8 ETO35341.1 - 0.14 12.2 2.0 0.16 11.9 0.0 2.1 2 0 0 2 2 2 0 BhlA holin family DUF4834 PF16118.5 ETO35341.1 - 0.28 12.2 0.0 0.28 12.2 0.0 3.2 3 1 0 3 3 3 0 Domain of unknown function (DUF4834) PBP1_TM PF14812.6 ETO35342.1 - 0.15 12.5 0.3 0.3 11.5 0.3 1.4 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal S_locus_glycop PF00954.20 ETO35342.1 - 1.8 9.1 8.7 0.98 10.0 3.6 2.9 3 0 0 3 3 3 0 S-locus glycoprotein domain adh_short PF00106.25 ETO35344.1 - 2.1e-42 144.8 2.6 3.3e-21 75.6 2.3 2.1 2 0 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO35344.1 - 1.4e-29 103.3 0.1 3.5e-16 59.5 0.1 2.1 2 0 0 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO35344.1 - 3.7e-06 27.0 0.0 8.9e-06 25.7 0.0 1.5 2 0 0 2 2 2 1 KR domain NAD_binding_10 PF13460.6 ETO35344.1 - 6.8e-06 26.1 0.0 0.018 14.9 0.0 2.1 2 0 0 2 2 2 2 NAD(P)H-binding Epimerase PF01370.21 ETO35344.1 - 0.0051 16.3 0.1 0.016 14.7 0.0 1.9 3 0 0 3 3 3 1 NAD dependent epimerase/dehydratase family 7TM_GPCR_Srt PF10321.9 ETO35344.1 - 0.024 13.6 0.9 0.026 13.5 0.1 1.4 2 0 0 2 2 2 0 Serpentine type 7TM GPCR chemoreceptor Srt DUF1959 PF09218.10 ETO35344.1 - 0.029 14.5 0.1 0.11 12.7 0.0 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF1959) PIG-F PF06699.11 ETO35344.1 - 0.092 12.9 0.4 0.17 12.1 0.1 1.6 2 0 0 2 2 2 0 GPI biosynthesis protein family Pig-F CDC45 PF02724.14 ETO35345.1 - 0.53 8.5 6.1 0.63 8.3 6.1 1.0 1 0 0 1 1 1 0 CDC45-like protein WD40 PF00400.32 ETO35346.1 - 4.3e-13 49.5 17.4 4.6e-06 27.3 4.2 4.4 3 2 1 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35346.1 - 0.00036 20.8 0.3 0.18 12.1 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35346.1 - 0.00049 18.9 0.7 0.61 8.7 0.0 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO35347.1 - 9.7e-62 203.5 15.9 3.2e-09 37.3 0.7 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35347.1 - 6.3e-21 74.5 3.3 0.0037 17.5 0.1 6.8 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35347.1 - 1.3e-12 47.4 4.7 0.6 9.0 0.0 6.9 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35347.1 - 3.6e-09 36.4 3.4 0.0076 15.6 0.1 4.2 3 2 1 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO35347.1 - 1e-07 31.0 4.8 0.87 8.2 0.2 5.6 3 1 3 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO35347.1 - 8.7e-05 21.2 2.6 0.38 9.2 0.1 3.2 1 1 1 3 3 3 2 Cytochrome D1 heme domain Str_synth PF03088.16 ETO35347.1 - 0.00013 22.0 0.6 2.7 8.2 0.0 4.9 3 1 2 5 5 5 1 Strictosidine synthase Nucleoporin_N PF08801.11 ETO35347.1 - 0.00084 18.2 5.2 1.3 7.7 0.0 4.1 2 1 2 4 4 4 2 Nup133 N terminal like PD40 PF07676.12 ETO35347.1 - 0.0032 17.4 4.2 17 5.5 0.0 4.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO35347.1 - 0.014 14.4 3.5 0.78 8.7 0.1 3.1 1 1 0 3 3 3 0 Coatomer WD associated region DUF5570 PF17731.1 ETO35347.1 - 0.022 14.9 4.3 3.1 7.9 0.6 3.5 2 2 2 5 5 5 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO35347.1 - 0.085 12.6 4.0 4.4 7.1 0.0 4.1 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature Coat_X PF07552.11 ETO35347.1 - 2.4 8.0 6.6 1 9.2 0.1 2.9 3 0 0 3 3 3 0 Spore Coat Protein X and V domain GST_N_3 PF13417.6 ETO35349.1 - 0.00033 21.0 0.0 0.2 12.1 0.0 2.5 2 0 0 2 2 2 2 Glutathione S-transferase, N-terminal domain GST_N_2 PF13409.6 ETO35349.1 - 0.0031 17.8 0.2 0.071 13.4 0.2 2.5 1 1 0 1 1 1 1 Glutathione S-transferase, N-terminal domain AAA_16 PF13191.6 ETO35351.1 - 1.5e-06 28.7 0.0 2e-06 28.3 0.0 1.2 1 0 0 1 1 1 1 AAA ATPase domain AAA_22 PF13401.6 ETO35351.1 - 0.0007 19.9 0.0 0.0013 19.0 0.0 1.4 2 0 0 2 2 2 1 AAA domain DUF815 PF05673.13 ETO35351.1 - 0.0028 16.9 0.0 0.0032 16.7 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF815) FtsK_SpoIIIE PF01580.18 ETO35351.1 - 0.012 15.0 0.0 0.015 14.6 0.0 1.1 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_29 PF13555.6 ETO35351.1 - 0.025 14.3 0.0 0.05 13.4 0.0 1.5 1 0 0 1 1 1 0 P-loop containing region of AAA domain Sigma54_activat PF00158.26 ETO35351.1 - 0.028 14.2 0.0 0.035 13.8 0.0 1.2 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA PF00004.29 ETO35351.1 - 0.049 14.1 0.0 0.07 13.6 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) NACHT PF05729.12 ETO35351.1 - 0.071 13.0 0.0 0.11 12.4 0.0 1.4 1 0 0 1 1 1 0 NACHT domain NTPase_1 PF03266.15 ETO35351.1 - 0.087 12.7 0.0 0.12 12.3 0.0 1.2 1 0 0 1 1 1 0 NTPase AAA_14 PF13173.6 ETO35351.1 - 0.11 12.5 0.0 0.16 12.0 0.0 1.3 1 0 0 1 1 1 0 AAA domain AAA_7 PF12775.7 ETO35351.1 - 0.13 11.7 0.0 0.17 11.4 0.0 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region TIP49 PF06068.13 ETO35351.1 - 0.17 11.1 0.0 0.21 10.8 0.0 1.1 1 0 0 1 1 1 0 TIP49 P-loop domain SH2 PF00017.24 ETO35352.1 - 9.6e-08 32.0 0.0 2.8e-07 30.5 0.0 1.7 1 0 0 1 1 1 1 SH2 domain DUF4264 PF14084.6 ETO35352.1 - 0.013 15.2 0.2 0.024 14.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF4264) NACHT PF05729.12 ETO35352.1 - 0.021 14.8 0.0 0.034 14.0 0.0 1.3 1 0 0 1 1 1 0 NACHT domain CTK3 PF12243.8 ETO35352.1 - 0.091 12.8 0.2 0.17 11.9 0.2 1.4 1 0 0 1 1 1 0 CTD kinase subunit gamma CTK3 Peptidase_S49_N PF08496.10 ETO35353.1 - 0.015 15.4 2.0 0.015 15.3 2.0 1.0 1 0 0 1 1 1 0 Peptidase family S49 N-terminal TMEMspv1-c74-12 PF11044.8 ETO35353.1 - 0.39 10.7 7.4 0.55 10.3 7.4 1.2 1 0 0 1 1 1 0 Plectrovirus spv1-c74 ORF 12 transmembrane protein COPIIcoated_ERV PF07970.12 ETO35354.1 - 2.9e-58 197.3 1.5 3.3e-58 197.2 1.5 1.0 1 0 0 1 1 1 1 Endoplasmic reticulum vesicle transporter CENP-B_dimeris PF09026.10 ETO35356.1 - 0.54 10.7 7.1 1 9.8 7.1 1.4 1 0 0 1 1 1 0 Centromere protein B dimerisation domain DUF1115 PF06544.12 ETO35356.1 - 1.1 9.4 6.5 2.2 8.4 6.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1115) FAM176 PF14851.6 ETO35356.1 - 1.4 8.6 7.3 0.26 10.9 3.7 1.7 2 0 0 2 2 2 0 FAM176 family Conotoxin PF02950.17 ETO35356.1 - 2.6 9.1 7.3 45 5.2 0.1 2.7 2 0 0 2 2 2 0 Conotoxin Sporozoite_P67 PF05642.11 ETO35356.1 - 7.3 4.5 9.5 10 4.0 9.5 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen VIR_N PF15912.5 ETO35356.1 - 8.9 5.8 12.3 12 5.4 12.3 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal Tubulin PF00091.25 ETO35357.1 - 7.8e-50 169.8 0.1 2.3e-47 161.7 0.1 2.0 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Lipase_3 PF01764.25 ETO35357.1 - 0.0093 15.8 0.0 0.013 15.4 0.0 1.2 1 0 0 1 1 1 1 Lipase (class 3) Tubulin_2 PF13809.6 ETO35357.1 - 0.17 11.0 0.0 0.24 10.5 0.0 1.2 1 0 0 1 1 1 0 Tubulin like Tubulin_C PF03953.17 ETO35358.1 - 2.4e-28 98.8 0.0 3.7e-28 98.2 0.0 1.2 1 0 0 1 1 1 1 Tubulin C-terminal domain Peptidase_S10 PF00450.22 ETO35359.1 - 3.7e-20 72.7 0.1 3.9e-20 72.7 0.1 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase LuxS PF02664.15 ETO35359.1 - 0.12 12.0 0.0 0.41 10.3 0.0 1.8 2 0 0 2 2 2 0 S-Ribosylhomocysteinase (LuxS) Tubulin PF00091.25 ETO35360.1 - 2.8e-41 141.9 0.0 4.1e-41 141.3 0.0 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO35360.1 - 6.2e-31 107.2 0.0 1.1e-30 106.4 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain Tubulin_2 PF13809.6 ETO35360.1 - 0.0067 15.7 0.0 0.012 14.8 0.0 1.4 1 0 0 1 1 1 1 Tubulin like PIEZO PF15917.5 ETO35363.1 - 0.048 13.2 1.1 0.044 13.3 1.1 1.1 1 0 0 1 1 1 0 Piezo WD40 PF00400.32 ETO35364.1 - 4.5e-25 87.4 4.7 1.2e-06 29.2 0.0 4.5 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35364.1 - 1.5e-05 25.2 0.1 0.33 11.3 0.0 2.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35364.1 - 2.1e-05 23.4 0.5 0.17 10.5 0.0 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35364.1 - 0.0025 17.2 0.5 0.83 8.9 0.1 2.8 2 1 0 2 2 2 2 WD40-like domain GSIII_N PF12437.8 ETO35365.1 - 0.085 12.5 1.1 0.096 12.3 1.1 1.1 1 0 0 1 1 1 0 Glutamine synthetase type III N terminal WD40 PF00400.32 ETO35366.1 - 6.8e-11 42.6 15.2 3.2e-06 27.8 0.7 5.0 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35366.1 - 2.3e-08 34.2 1.9 0.00052 20.3 0.1 3.4 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO35366.1 - 3.1e-05 24.0 0.4 0.59 10.0 0.0 3.4 1 1 2 3 3 3 2 Eukaryotic translation initiation factor eIF2A WD40 PF00400.32 ETO35368.1 - 2.8e-15 56.4 3.5 2.6e-07 31.2 0.2 3.5 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35368.1 - 1.5e-06 28.4 0.6 0.011 16.1 0.1 2.4 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35368.1 - 0.0085 15.4 4.0 0.58 9.4 0.2 2.8 2 1 0 3 3 3 2 WD40-like domain PQQ_3 PF13570.6 ETO35368.1 - 0.078 13.5 0.1 11 6.7 0.1 2.5 2 1 0 2 2 2 0 PQQ-like domain GAS PF13851.6 ETO35368.1 - 0.1 11.9 4.8 0.14 11.5 4.8 1.1 1 0 0 1 1 1 0 Growth-arrest specific micro-tubule binding DUF4239 PF14023.6 ETO35368.1 - 0.17 11.6 0.0 0.2 11.3 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4239) vATP-synt_E PF01991.18 ETO35368.1 - 0.34 10.3 4.1 0.48 9.8 4.1 1.1 1 0 0 1 1 1 0 ATP synthase (E/31 kDa) subunit Proteasome PF00227.26 ETO35369.1 - 9.1e-05 22.0 0.3 0.00018 21.1 0.3 1.5 1 0 0 1 1 1 1 Proteasome subunit RRM_1 PF00076.22 ETO35370.1 - 1.1e-14 54.0 0.4 8.4e-14 51.2 0.1 2.5 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_7 PF16367.5 ETO35370.1 - 0.045 13.9 0.6 0.44 10.7 0.0 2.9 2 2 0 2 2 2 0 RNA recognition motif Sgf11 PF08209.11 ETO35371.1 - 0.071 12.7 0.3 0.15 11.7 0.3 1.5 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) WD40 PF00400.32 ETO35372.1 - 1.8e-06 28.6 1.3 1.8e-06 28.6 1.3 2.7 3 0 0 3 3 3 1 WD domain, G-beta repeat SelK_SelG PF10961.8 ETO35372.1 - 0.81 10.3 8.1 3.8 8.2 2.9 2.4 2 0 0 2 2 2 0 Selenoprotein SelK_SelG WD40 PF00400.32 ETO35373.1 - 1.9e-26 91.7 10.7 2.2e-07 31.4 0.4 4.8 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35373.1 - 2.5e-10 40.5 0.1 0.0069 16.7 0.0 4.0 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35373.1 - 5.1e-10 38.6 1.4 0.044 12.4 0.0 4.0 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35373.1 - 1.1e-05 24.9 1.2 0.01 15.2 0.2 2.9 2 1 1 3 3 3 2 WD40-like domain DUF4979 PF16351.5 ETO35373.1 - 0.093 13.0 4.0 4.4 7.5 0.9 3.1 1 1 2 3 3 3 0 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO35376.1 - 0.00081 20.2 0.2 0.0018 19.1 0.2 1.7 2 0 0 2 2 2 1 WD domain, G-beta repeat WD40 PF00400.32 ETO35377.1 - 2.6e-08 34.4 5.7 1.1e-05 26.0 1.1 3.4 3 1 0 3 3 3 2 WD domain, G-beta repeat zf-TRAF PF02176.18 ETO35378.1 - 6.5e-05 23.5 5.1 6.5e-05 23.5 5.1 2.5 3 0 0 3 3 3 1 TRAF-type zinc finger Cep57_CLD_2 PF14197.6 ETO35378.1 - 0.0035 17.4 1.2 0.0035 17.4 1.2 3.2 1 1 1 2 2 2 1 Centrosome localisation domain of PPC89 TSNAXIP1_N PF15739.5 ETO35378.1 - 0.01 16.2 4.8 0.01 16.2 4.8 2.8 1 1 1 2 2 2 1 Translin-associated factor X-interacting N-terminus Hemocyanin_C PF03723.14 ETO35378.1 - 0.017 14.5 7.5 0.027 13.8 7.5 1.3 1 0 0 1 1 1 0 Hemocyanin, ig-like domain DUF4407 PF14362.6 ETO35378.1 - 0.035 13.5 6.4 0.047 13.0 6.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Atg14 PF10186.9 ETO35378.1 - 0.11 11.6 21.1 0.017 14.3 16.7 1.9 2 0 0 2 2 2 0 Vacuolar sorting 38 and autophagy-related subunit 14 GCD14 PF08704.10 ETO35378.1 - 0.69 9.5 9.6 1.2 8.8 9.6 1.5 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit DUF724 PF05266.14 ETO35378.1 - 2.1 8.1 30.2 0.06 13.2 18.8 2.6 2 1 1 3 3 3 0 Protein of unknown function (DUF724) CC2-LZ PF16516.5 ETO35378.1 - 2.8 8.4 27.4 2 8.8 5.8 3.4 2 1 1 3 3 3 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator TMF_DNA_bd PF12329.8 ETO35378.1 - 4.1 7.5 34.7 0.74 9.9 22.4 3.5 1 1 2 3 3 3 0 TATA element modulatory factor 1 DNA binding DUF641 PF04859.12 ETO35378.1 - 4.2 7.7 19.9 5.6 7.3 5.3 2.7 1 1 1 2 2 2 0 Plant protein of unknown function (DUF641) WD40 PF00400.32 ETO35379.1 - 3.5e-05 24.5 0.3 3.5e-05 24.5 0.3 2.4 2 2 0 2 2 2 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO35379.1 - 0.022 13.4 0.0 0.023 13.3 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Borrelia_P83 PF05262.11 ETO35379.1 - 0.091 11.2 0.0 0.11 11.0 0.0 1.1 1 0 0 1 1 1 0 Borrelia P83/100 protein TPR_12 PF13424.6 ETO35380.1 - 2e-29 101.7 5.4 1.3e-14 54.3 0.4 3.2 3 0 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35380.1 - 1.2e-20 72.7 1.0 5.1e-05 23.0 0.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35380.1 - 2.4e-19 67.9 5.1 9.4e-06 25.3 0.5 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35380.1 - 2.8e-19 68.0 18.1 1.5e-06 27.8 0.6 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35380.1 - 3e-17 61.3 13.5 4.6e-05 23.3 1.0 5.1 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35380.1 - 1.3e-16 59.3 12.9 1.4e-06 28.0 0.4 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35380.1 - 1.3e-09 37.6 9.4 0.00044 19.9 0.3 5.1 4 1 1 5 5 5 2 TPR repeat TPR_17 PF13431.6 ETO35380.1 - 8.6e-08 32.0 4.6 0.046 14.1 0.2 4.7 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO35380.1 - 3e-07 30.7 0.1 0.19 12.6 0.0 4.2 4 0 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO35380.1 - 9.4e-06 25.6 6.8 0.16 12.1 0.0 4.2 2 1 1 4 4 4 2 MIT (microtubule interacting and transport) domain TPR_MalT PF17874.1 ETO35380.1 - 1.6e-05 24.4 0.8 0.00024 20.6 0.0 2.4 2 1 0 2 2 2 1 MalT-like TPR region TPR_16 PF13432.6 ETO35380.1 - 0.0002 21.9 0.0 0.098 13.3 0.0 2.7 2 1 0 2 2 2 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO35380.1 - 0.0027 17.9 9.2 0.14 12.4 0.9 3.3 2 1 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO35380.1 - 0.0028 17.5 12.7 0.0032 17.3 1.0 3.8 2 1 3 5 5 5 1 Domain of unknown function (DUF5113) SHNi-TPR PF10516.9 ETO35380.1 - 0.031 13.7 0.1 4.3 6.9 0.0 3.0 3 0 0 3 3 3 0 SHNi-TPR TPR_6 PF13174.6 ETO35380.1 - 0.037 14.7 1.9 13 6.6 0.0 4.2 4 0 0 4 4 3 0 Tetratricopeptide repeat WD40 PF00400.32 ETO35381.1 - 2.3e-51 170.7 19.7 5.7e-09 36.5 0.0 9.0 9 0 0 9 9 9 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35381.1 - 1.3e-14 54.3 4.1 0.069 13.5 0.0 7.5 3 3 4 7 7 7 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35381.1 - 7.1e-11 41.6 0.9 0.18 10.7 0.0 5.3 2 2 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO35381.1 - 5.8e-08 31.7 0.3 1.7e-06 26.9 0.1 2.8 3 0 0 3 3 3 1 Cytochrome D1 heme domain Kelch_2 PF07646.15 ETO35381.1 - 1e-05 25.3 0.9 0.21 11.6 0.0 4.5 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO35381.1 - 0.00025 21.2 0.0 0.0014 18.8 0.0 2.4 1 0 0 1 1 1 1 Galactose oxidase, central domain Nup160 PF11715.8 ETO35381.1 - 0.0015 17.2 5.3 1.5 7.4 0.0 4.0 1 1 2 4 4 4 2 Nucleoporin Nup120/160 Kelch_5 PF13854.6 ETO35381.1 - 0.0017 18.3 6.6 0.34 11.0 0.0 4.6 5 0 0 5 5 5 1 Kelch motif Nucleoporin_N PF08801.11 ETO35381.1 - 0.0018 17.1 12.8 0.57 8.9 0.0 5.0 3 1 4 7 7 7 2 Nup133 N terminal like Kelch_4 PF13418.6 ETO35381.1 - 0.0079 16.2 0.8 0.48 10.5 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO35381.1 - 0.0094 15.5 1.8 1.2 8.8 0.1 3.6 3 0 0 3 3 3 1 Kelch motif FRG1 PF06229.12 ETO35381.1 - 0.16 11.7 0.6 0.3 10.8 0.6 1.4 1 0 0 1 1 1 0 FRG1-like domain PD40 PF07676.12 ETO35381.1 - 0.2 11.6 1.1 77 3.4 0.1 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF5122 PF17164.4 ETO35381.1 - 0.25 11.7 1.2 0.96 9.8 0.0 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller Metallophos PF00149.28 ETO35383.1 - 8e-06 26.5 0.0 2e-05 25.2 0.0 1.7 2 0 0 2 2 2 1 Calcineurin-like phosphoesterase WD40 PF00400.32 ETO35386.1 - 1.1e-10 41.8 0.9 3.8e-08 33.9 0.9 2.4 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35386.1 - 1.9e-05 23.5 0.1 2e-05 23.5 0.1 1.0 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35386.1 - 0.00037 20.7 0.0 0.00047 20.4 0.0 1.1 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain DUF4221 PF13970.6 ETO35386.1 - 0.016 14.8 0.6 0.019 14.6 0.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4221) TbpB_A PF17484.2 ETO35387.1 - 1.4 9.7 11.0 3 8.6 11.0 1.6 1 1 0 1 1 1 0 N-Lobe handle Tf-binding protein B Plant_tran PF04827.14 ETO35388.1 - 0.012 15.2 0.5 0.014 15.0 0.5 1.1 1 0 0 1 1 1 0 Plant transposon protein Cue1_U7BR PF18499.1 ETO35388.1 - 0.057 13.5 3.3 0.34 11.0 0.1 2.6 2 1 0 2 2 2 0 Ubc7p-binding region of Cue1 WD40 PF00400.32 ETO35389.1 - 7e-20 71.0 19.8 5.3e-06 27.1 2.2 5.8 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35389.1 - 9.4e-07 29.0 0.2 0.085 13.2 0.0 4.1 3 1 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35389.1 - 0.00015 20.5 6.8 0.12 10.9 0.1 4.6 1 1 4 5 5 5 3 Nucleoporin Nup120/160 Iron_permease PF04120.12 ETO35390.1 - 0.024 14.4 3.4 0.057 13.2 3.4 1.6 1 0 0 1 1 1 0 Low affinity iron permease ExbD PF02472.16 ETO35390.1 - 0.027 14.7 2.0 0.049 13.8 1.1 1.8 1 1 1 2 2 2 0 Biopolymer transport protein ExbD/TolR CLN3 PF02487.17 ETO35390.1 - 0.063 12.3 1.6 0.094 11.7 1.6 1.2 1 0 0 1 1 1 0 CLN3 protein Acetone_carb_G PF08882.11 ETO35390.1 - 0.11 12.6 1.4 0.28 11.4 1.4 1.7 1 1 0 1 1 1 0 Acetone carboxylase gamma subunit DUF262 PF03235.14 ETO35390.1 - 0.6 10.2 10.1 0.75 9.9 0.9 2.2 2 0 0 2 2 2 0 Protein of unknown function DUF262 Afi1 PF07792.12 ETO35390.1 - 2.2 8.8 11.2 0.65 10.5 7.2 2.0 1 1 1 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2681 PF10883.8 ETO35390.1 - 3.7 8.0 11.9 1.7 9.1 8.7 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF2681) Ras PF00071.22 ETO35391.1 - 8.1e-46 155.6 5.6 1.1e-42 145.4 5.0 3.4 2 1 0 2 2 2 1 Ras family Roc PF08477.13 ETO35391.1 - 4.4e-32 110.8 0.7 4.5e-31 107.5 0.2 2.6 2 1 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO35391.1 - 9.2e-16 57.8 3.2 2.9e-15 56.1 1.2 2.5 2 1 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO35391.1 - 9.9e-07 28.5 2.4 4.8e-06 26.2 2.4 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO35391.1 - 8.9e-05 21.9 0.1 8.9e-05 21.9 0.1 2.0 1 1 1 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO35391.1 - 0.0021 18.1 0.0 0.011 15.8 0.0 2.2 2 1 0 2 2 2 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO35391.1 - 0.027 14.4 2.6 4.6 7.1 0.0 2.8 2 1 1 3 3 3 0 RsgA GTPase TniB PF05621.11 ETO35391.1 - 0.032 13.7 0.0 0.069 12.6 0.0 1.5 1 0 0 1 1 1 0 Bacterial TniB protein AAA_16 PF13191.6 ETO35391.1 - 0.095 13.1 0.0 0.25 11.7 0.0 1.7 2 0 0 2 2 2 0 AAA ATPase domain zf-C2H2 PF00096.26 ETO35392.1 - 4.4e-09 36.3 10.9 6.6e-05 23.2 2.4 2.7 2 0 0 2 2 2 2 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO35392.1 - 1.4e-08 34.8 8.1 0.001 19.7 1.1 3.1 2 0 0 2 2 2 2 C2H2-type zinc finger zf-C2H2_6 PF13912.6 ETO35392.1 - 0.00024 21.0 4.2 0.0065 16.4 0.5 2.5 2 0 0 2 2 2 2 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO35392.1 - 0.00051 20.4 14.8 0.017 15.5 3.8 3.8 3 1 0 3 3 3 2 Zinc-finger double domain zf-C2H2_jaz PF12171.8 ETO35392.1 - 0.01 16.1 4.6 0.32 11.3 0.7 2.6 2 0 0 2 2 2 2 Zinc-finger double-stranded RNA-binding zf-C2H2_11 PF16622.5 ETO35392.1 - 0.023 14.4 3.5 0.097 12.4 0.4 2.7 2 0 0 2 2 2 0 zinc-finger C2H2-type Zn-ribbon_8 PF09723.10 ETO35392.1 - 0.037 14.1 2.8 0.037 14.1 2.8 1.9 2 0 0 2 2 2 0 Zinc ribbon domain zf-Di19 PF05605.12 ETO35392.1 - 0.15 12.4 4.8 3.5 8.0 4.8 2.7 1 1 0 1 1 1 0 Drought induced 19 protein (Di19), zinc-binding zf-C2HC_2 PF13913.6 ETO35392.1 - 0.17 11.8 0.3 0.17 11.8 0.3 2.4 2 0 0 2 2 2 0 zinc-finger of a C2HC-type zf-met PF12874.7 ETO35392.1 - 1 9.9 4.8 1.8 9.1 0.3 2.8 3 0 0 3 3 3 0 Zinc-finger of C2H2 type Cpn60_TCP1 PF00118.24 ETO35394.1 - 4e-39 134.6 1.9 4.9e-39 134.3 1.9 1.0 1 0 0 1 1 1 1 TCP-1/cpn60 chaperonin family TrmE_N PF10396.9 ETO35394.1 - 0.084 13.2 0.1 7.3 6.9 0.0 2.6 2 1 0 2 2 2 0 GTP-binding protein TrmE N-terminus VGPC1_C PF16799.5 ETO35394.1 - 0.12 12.3 0.8 2 8.4 0.1 2.3 2 0 0 2 2 2 0 C-terminal membrane-localisation domain of ion-channel, VCN1 BRCA-2_OB3 PF09104.10 ETO35394.1 - 0.15 11.7 0.1 6.2 6.5 0.0 2.7 2 1 1 3 3 3 0 BRCA2, oligonucleotide/oligosaccharide-binding, domain 3 GTP-bdg_M PF16360.5 ETO35394.1 - 0.2 12.3 2.1 0.5 11.0 0.7 2.1 1 1 1 2 2 2 0 GTP-binding GTPase Middle Region Ank_2 PF12796.7 ETO35395.1 - 0.025 15.2 0.0 0.035 14.7 0.0 1.2 1 0 0 1 1 1 0 Ankyrin repeats (3 copies) Neur_chan_memb PF02932.16 ETO35396.1 - 0.17 11.9 11.4 0.24 11.4 11.4 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region PAT1 PF09770.9 ETO35396.1 - 0.32 9.2 26.4 0.31 9.3 26.4 1.1 1 0 0 1 1 1 0 Topoisomerase II-associated protein PAT1 Trypan_PARP PF05887.11 ETO35396.1 - 0.34 10.9 6.7 0.035 14.1 2.2 1.6 1 1 1 2 2 2 0 Procyclic acidic repetitive protein (PARP) Hid1 PF12722.7 ETO35396.1 - 2.2 6.3 15.2 2.5 6.1 15.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Borrelia_P83 PF05262.11 ETO35396.1 - 2.6 6.4 17.8 2.8 6.3 17.8 1.2 1 0 0 1 1 1 0 Borrelia P83/100 protein Menin PF05053.13 ETO35396.1 - 4.7 5.4 12.1 5.7 5.2 12.1 1.1 1 0 0 1 1 1 0 Menin SRP-alpha_N PF04086.13 ETO35396.1 - 5.4 6.8 21.8 7.2 6.4 21.8 1.2 1 1 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal DUF4131 PF13567.6 ETO35397.1 - 5 6.8 11.9 0.6 9.7 1.8 3.1 3 0 0 3 3 3 0 Domain of unknown function (DUF4131) Gpi1 PF05024.15 ETO35398.1 - 6.2e-33 114.4 6.6 6.2e-33 114.4 6.6 2.1 2 0 0 2 2 2 1 N-acetylglucosaminyl transferase component (Gpi1) Pkinase_Tyr PF07714.17 ETO35399.1 - 1.3e-05 24.7 0.0 1.9e-05 24.1 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO35399.1 - 0.0001 21.8 0.0 0.00017 21.1 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ETO35401.1 - 1.1e-09 38.7 7.2 0.0035 18.2 0.4 5.9 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35401.1 - 0.0031 17.8 0.1 14 6.0 0.1 4.2 4 0 0 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain PH PF00169.29 ETO35402.1 - 8.6e-05 23.0 0.0 0.00032 21.2 0.0 2.0 1 0 0 1 1 1 1 PH domain RhoGEF PF00621.20 ETO35402.1 - 0.00058 20.2 0.4 0.0034 17.6 0.1 2.0 2 0 0 2 2 2 1 RhoGEF domain SAG PF04092.13 ETO35405.1 - 0.011 16.5 2.1 0.014 16.2 2.1 1.2 1 0 0 1 1 1 0 SRS domain Dexa_ind PF15198.6 ETO35405.1 - 1.2 9.2 3.2 0.97 9.6 1.9 1.6 1 1 0 1 1 1 0 Dexamethasone-induced WD40 PF00400.32 ETO35407.1 - 0.00042 21.1 0.2 0.0032 18.3 0.2 2.3 2 1 0 2 2 2 1 WD domain, G-beta repeat Ground-like PF04155.18 ETO35408.1 - 0.087 13.5 2.8 0.18 12.5 2.8 1.5 1 1 0 1 1 1 0 Ground-like domain Cys_rich_VLP PF14194.6 ETO35408.1 - 0.15 12.2 5.0 0.17 12.0 0.6 2.3 2 0 0 2 2 2 0 Cysteine-rich VLP WD40 PF00400.32 ETO35409.1 - 9.3e-124 399.7 57.7 7.2e-11 42.5 0.6 16.3 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35409.1 - 2.7e-31 107.7 20.0 0.0074 16.6 0.0 13.4 2 2 13 15 15 15 12 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35409.1 - 2.6e-21 76.0 6.9 0.0062 15.5 0.0 12.2 1 1 11 14 14 14 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35409.1 - 6.1e-13 48.8 24.9 0.0023 17.3 0.0 7.6 6 3 2 8 8 8 5 WD40-like domain Pentapeptide PF00805.22 ETO35409.1 - 1.6e-07 30.8 1.8 3.5e-07 29.7 1.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Me-amine-dh_H PF06433.11 ETO35409.1 - 3.5e-06 26.1 0.2 0.51 9.1 0.0 4.8 3 1 0 5 5 5 1 Methylamine dehydrogenase heavy chain (MADH) PQQ_2 PF13360.6 ETO35409.1 - 5.3e-06 26.2 0.4 0.02 14.5 0.1 3.7 1 1 1 2 2 2 2 PQQ-like domain Mid2 PF04478.12 ETO35409.1 - 5.5e-06 26.3 4.8 4.8 7.0 0.1 7.0 5 2 1 7 7 7 1 Mid2 like cell wall stress sensor HARP PF07443.13 ETO35409.1 - 1.4e-05 24.6 1.1 13 5.5 0.0 7.4 9 0 0 9 9 9 0 HepA-related protein (HARP) PD40 PF07676.12 ETO35409.1 - 1.7e-05 24.6 11.1 0.99 9.4 0.0 8.5 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO35409.1 - 4.7e-05 23.5 0.4 0.00011 22.2 0.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Str_synth PF03088.16 ETO35409.1 - 0.00016 21.8 0.1 34 4.6 0.0 6.2 5 2 1 6 6 6 0 Strictosidine synthase DUF727 PF05303.12 ETO35409.1 - 0.00058 19.9 10.6 13 5.9 0.0 9.0 5 4 5 10 10 10 0 Protein of unknown function (DUF727) Pentapeptide_3 PF13576.6 ETO35409.1 - 0.0021 18.1 0.6 0.0056 16.8 0.6 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO35409.1 - 0.0042 15.7 8.2 0.059 11.9 0.3 4.3 2 1 3 5 5 5 1 Cytochrome D1 heme domain DUF3475 PF11961.8 ETO35409.1 - 0.032 14.3 1.4 2.1e+02 2.1 0.0 5.7 6 0 0 6 6 6 0 Domain of unknown function (DUF3475) DUF1938 PF09153.10 ETO35409.1 - 0.14 12.2 1.2 25 5.0 0.1 3.8 4 0 0 4 4 3 0 Domain of unknown function (DUF1938) E2F_CC-MB PF16421.5 ETO35410.1 - 0.084 13.2 1.5 1.3 9.5 0.9 2.2 1 1 1 2 2 2 0 E2F transcription factor CC-MB domain DUF2721 PF11026.8 ETO35410.1 - 1.3 9.0 8.7 1.6 8.6 0.6 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF2721) ELFV_dehydrog PF00208.21 ETO35411.1 - 1.5e-21 77.3 0.3 2.1e-21 76.8 0.3 1.2 1 0 0 1 1 1 1 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase RuvC_III PF18541.1 ETO35411.1 - 0.076 12.9 0.4 0.15 12.0 0.1 1.5 2 0 0 2 2 2 0 RuvC endonuclease subdomain 3 WHEP-TRS PF00458.20 ETO35412.1 - 0.059 13.5 2.2 0.37 11.0 0.2 2.5 2 0 0 2 2 2 0 WHEP-TRS domain DUF2281 PF10047.9 ETO35413.1 - 0.098 13.4 3.6 0.2 12.4 3.6 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2281) ORC6 PF05460.13 ETO35415.1 - 0.047 12.9 2.0 0.066 12.5 2.0 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) CNDH2_M PF16869.5 ETO35415.1 - 0.053 14.2 0.1 0.053 14.2 0.1 2.1 2 1 0 2 2 2 0 PF16858 ABC_tran PF00005.27 ETO35416.1 - 6.7e-08 33.1 0.0 1.4e-07 32.1 0.0 1.5 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ETO35416.1 - 0.13 11.7 0.0 0.19 11.1 0.0 1.2 1 0 0 1 1 1 0 RecF/RecN/SMC N terminal domain Aminotran_5 PF00266.19 ETO35417.1 - 2.4e-14 53.1 0.0 1.7e-13 50.3 0.0 1.9 1 1 0 1 1 1 1 Aminotransferase class-V Chromo_2 PF18704.1 ETO35421.1 - 0.0055 17.0 0.3 0.014 15.6 0.3 1.7 1 0 0 1 1 1 1 Chromatin organization modifier domain 2 MutS_IV PF05190.18 ETO35422.1 - 4.3e-06 27.0 0.0 1.6e-05 25.1 0.0 2.0 2 0 0 2 2 2 1 MutS family domain IV MutS_III PF05192.18 ETO35422.1 - 0.00011 22.5 0.0 0.00019 21.7 0.0 1.4 1 1 0 1 1 1 1 MutS domain III MnmE_helical PF12631.7 ETO35422.1 - 0.013 15.7 0.1 0.02 15.0 0.1 1.3 1 0 0 1 1 1 0 MnmE helical domain MutS_V PF00488.21 ETO35423.1 - 7.1e-80 267.5 0.1 9.3e-80 267.1 0.1 1.1 1 0 0 1 1 1 1 MutS domain V AAA_27 PF13514.6 ETO35423.1 - 0.015 14.9 0.0 0.044 13.4 0.0 1.7 2 0 0 2 2 2 0 AAA domain Kinesin PF00225.23 ETO35424.1 - 2.9e-12 46.2 1.0 3.3e-12 46.0 0.6 1.4 1 1 1 2 2 2 1 Kinesin motor domain Microtub_bd PF16796.5 ETO35424.1 - 0.0004 20.4 0.1 0.0004 20.4 0.1 1.5 2 0 0 2 2 2 1 Microtubule binding UPF0121 PF03661.13 ETO35426.1 - 0.001 18.5 0.1 0.0017 17.8 0.1 1.3 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) DUF3959 PF13105.6 ETO35426.1 - 0.02 14.4 0.2 0.042 13.3 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3959) MutS_III PF05192.18 ETO35427.1 - 2.6e-17 63.7 0.7 2.3e-16 60.6 0.0 2.3 2 1 0 2 2 2 1 MutS domain III MutS_II PF05188.17 ETO35427.1 - 4.8e-07 30.1 0.1 8.4e-07 29.3 0.1 1.4 1 0 0 1 1 1 1 MutS domain II MutS_I PF01624.20 ETO35427.1 - 1.8e-05 24.9 0.3 0.00012 22.3 0.0 2.3 2 1 0 2 2 2 1 MutS domain I UPF0121 PF03661.13 ETO35427.1 - 0.0029 17.0 0.4 0.0075 15.7 0.4 1.7 1 0 0 1 1 1 1 Uncharacterised protein family (UPF0121) Fea1 PF07692.11 ETO35427.1 - 0.043 12.9 0.1 0.074 12.1 0.1 1.3 1 0 0 1 1 1 0 Low iron-inducible periplasmic protein DUF4790 PF16037.5 ETO35427.1 - 0.068 13.6 2.6 0.17 12.3 2.6 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4790) WD40 PF00400.32 ETO35428.1 - 7e-68 222.9 30.4 6.8e-09 36.2 0.1 10.2 10 0 0 10 10 10 9 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35428.1 - 1.1e-23 83.3 6.4 0.015 15.6 0.0 7.8 1 1 8 9 9 9 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35428.1 - 2.5e-17 63.2 9.8 6.5e-05 22.4 0.0 4.6 2 2 2 4 4 4 4 WD40-like domain Nup160 PF11715.8 ETO35428.1 - 1.8e-13 50.0 11.5 0.49 9.0 0.0 8.8 1 1 6 9 9 9 5 Nucleoporin Nup120/160 Ge1_WD40 PF16529.5 ETO35428.1 - 3.8e-12 45.8 3.7 0.016 14.2 0.5 6.5 1 1 2 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nbas_N PF15492.6 ETO35428.1 - 2.9e-05 23.5 8.1 0.39 10.0 0.1 5.6 2 2 3 7 7 7 2 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO35428.1 - 0.00014 21.7 7.5 14 5.7 0.2 6.4 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat DPPIV_N PF00930.21 ETO35428.1 - 0.00052 18.9 1.1 0.057 12.2 0.1 3.5 3 2 1 5 5 5 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region PQQ_2 PF13360.6 ETO35428.1 - 0.00095 18.8 0.0 0.76 9.3 0.0 3.2 1 1 1 2 2 2 2 PQQ-like domain Mid2 PF04478.12 ETO35428.1 - 0.0028 17.5 1.4 3.2 7.6 0.1 3.5 2 1 1 3 3 3 2 Mid2 like cell wall stress sensor Utp8 PF10395.9 ETO35428.1 - 0.0063 15.1 3.5 0.023 13.2 0.3 2.7 1 1 1 2 2 2 1 Utp8 family DUF4988 PF16378.5 ETO35428.1 - 0.0065 16.2 0.5 12 5.5 0.0 3.9 3 3 1 4 4 4 1 Domain of unknown function HARP PF07443.13 ETO35428.1 - 0.011 15.4 0.1 3.1 7.5 0.0 3.5 4 0 0 4 4 4 0 HepA-related protein (HARP) CNH PF00780.22 ETO35428.1 - 0.033 13.8 0.2 0.45 10.1 0.0 2.7 3 1 0 3 3 3 0 CNH domain YqaJ PF09588.10 ETO35428.1 - 0.36 11.0 1.3 18 5.5 1.2 3.1 1 1 0 1 1 1 0 YqaJ-like viral recombinase domain CRIM PF16978.5 ETO35429.1 - 0.0035 17.5 0.1 0.0066 16.6 0.1 1.5 1 0 0 1 1 1 1 SAPK-interacting protein 1 (Sin1), middle CRIM domain SAVED PF18145.1 ETO35429.1 - 0.044 13.6 0.0 0.12 12.2 0.0 1.7 2 0 0 2 2 2 0 SMODS-associated and fused to various effectors sensor domain WD40 PF00400.32 ETO35430.1 - 1.3e-19 70.2 13.1 4.5e-05 24.1 0.4 4.6 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35430.1 - 2.9e-05 24.3 0.1 0.019 15.2 0.0 3.0 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35430.1 - 0.0015 17.3 0.8 1.6 7.3 0.0 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40 PF00400.32 ETO35431.1 - 3.8e-17 62.3 12.7 3e-06 27.8 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35431.1 - 4.5e-08 33.3 0.9 0.0065 16.8 0.0 3.3 3 2 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35431.1 - 9.1e-07 28.5 3.5 0.00077 18.9 0.9 3.1 1 1 2 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO35431.1 - 2.2e-05 23.3 1.7 0.41 9.2 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 DUF4770 PF15994.5 ETO35432.1 - 0.047 13.9 3.0 0.09 13.0 3.0 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) Eapp_C PF10238.9 ETO35432.1 - 0.14 12.3 0.1 0.14 12.3 0.1 1.7 2 0 0 2 2 2 0 E2F-associated phosphoprotein WD40 PF00400.32 ETO35433.1 - 1.1e-42 143.2 26.5 1.6e-06 28.7 0.1 7.1 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35433.1 - 8.8e-14 51.6 2.7 0.0034 17.6 0.0 5.8 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35433.1 - 8e-11 41.3 7.9 0.026 13.2 0.3 5.4 1 1 3 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35433.1 - 4.2e-07 29.6 8.0 0.014 14.8 0.6 4.2 3 2 2 5 5 5 3 WD40-like domain DUF1541 PF07563.11 ETO35433.1 - 0.11 12.5 0.0 62 3.6 0.0 3.4 3 0 0 3 3 3 0 Protein of unknown function (DUF1541) PQQ_3 PF13570.6 ETO35433.1 - 0.16 12.5 0.2 1.5e+02 3.0 0.0 4.3 6 0 0 6 6 6 0 PQQ-like domain WD40 PF00400.32 ETO35434.1 - 7.2e-11 42.5 3.5 6e-05 23.7 0.1 3.3 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35434.1 - 0.011 14.4 0.1 2.2 6.8 0.0 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 WD40 PF00400.32 ETO35435.1 - 1e-39 133.8 28.8 2.6e-08 34.4 0.1 7.8 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35435.1 - 8.8e-13 48.4 2.3 0.007 16.6 0.0 6.2 6 1 0 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35435.1 - 3.6e-11 42.4 10.4 0.064 11.9 0.1 6.0 1 1 4 6 6 6 6 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35435.1 - 4.5e-06 26.2 11.6 0.005 16.2 1.0 5.1 2 2 3 6 6 6 3 WD40-like domain SNAPc_SNAP43 PF09808.9 ETO35435.1 - 0.014 15.3 0.1 0.029 14.3 0.1 1.5 1 0 0 1 1 1 0 Small nuclear RNA activating complex (SNAPc), subunit SNAP43 DUF4703 PF15775.5 ETO35435.1 - 0.16 11.8 0.0 0.49 10.2 0.0 1.7 2 0 0 2 2 2 0 Domain of unknown function (DUF4703) WD40 PF00400.32 ETO35436.1 - 4.9e-23 81.0 15.5 1.9e-07 31.7 2.4 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35436.1 - 3.8e-07 30.3 0.0 0.024 14.9 0.1 3.2 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35436.1 - 3.7e-06 25.9 0.4 0.27 9.8 0.1 3.2 1 1 2 3 3 3 3 Nucleoporin Nup120/160 TolA_bind_tri PF16331.5 ETO35436.1 - 0.55 10.4 6.7 0.1 12.7 0.8 2.3 1 1 1 2 2 2 0 TolA binding protein trimerisation Drc1-Sld2 PF11719.8 ETO35436.1 - 1.4 8.4 11.0 2.1 7.8 11.0 1.1 1 0 0 1 1 1 0 DNA replication and checkpoint protein WD40 PF00400.32 ETO35438.1 - 1.1e-40 136.8 19.5 7.1e-07 29.8 1.4 6.7 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35438.1 - 6e-11 42.5 1.5 0.057 13.7 0.0 5.3 5 1 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35438.1 - 9.8e-09 34.4 6.3 0.034 12.8 0.1 4.8 2 1 0 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35438.1 - 0.00056 19.3 4.0 0.034 13.5 0.2 3.7 3 1 0 3 3 3 1 WD40-like domain PALB2_WD40 PF16756.5 ETO35438.1 - 0.019 13.9 0.0 0.47 9.3 0.0 2.5 3 0 0 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Kelch_1 PF01344.25 ETO35439.1 - 1.9e-05 24.2 0.1 0.0042 16.6 0.0 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO35439.1 - 0.0055 16.9 0.1 6.4 7.2 0.0 3.2 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO35439.1 - 0.0078 16.2 0.0 0.15 12.0 0.0 3.1 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35439.1 - 0.018 15.0 2.5 0.98 9.5 0.1 3.5 4 0 0 4 4 4 0 Kelch motif Kelch_2 PF07646.15 ETO35439.1 - 0.031 14.3 1.7 3.1 7.9 0.0 3.7 4 0 0 4 4 4 0 Kelch motif zf-C2H2_10 PF16588.5 ETO35439.1 - 0.2 11.4 3.0 1.1 9.1 0.5 2.8 2 0 0 2 2 2 0 C2H2 zinc-finger FANCI_S1 PF14675.6 ETO35440.1 - 0.00044 19.9 0.3 0.00054 19.6 0.3 1.1 1 0 0 1 1 1 1 FANCI solenoid 1 Cnd1_N PF12922.7 ETO35440.1 - 0.52 10.1 3.1 0.24 11.3 0.6 1.7 2 0 0 2 2 2 0 non-SMC mitotic condensation complex subunit 1, N-term Pkinase PF00069.25 ETO35441.1 - 0.0099 15.3 0.8 0.012 15.0 0.1 1.5 2 0 0 2 2 2 1 Protein kinase domain SET PF00856.28 ETO35442.1 - 4.7e-05 23.8 0.0 0.00015 22.2 0.0 1.9 1 1 0 1 1 1 1 SET domain Pkinase PF00069.25 ETO35443.1 - 9.1e-60 202.2 0.0 1.4e-59 201.6 0.0 1.3 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35443.1 - 5.5e-23 81.6 0.0 9.6e-23 80.8 0.0 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EF-hand_1 PF00036.32 ETO35443.1 - 1.3e-16 58.8 6.8 2e-05 23.8 0.1 4.7 4 0 0 4 4 4 4 EF hand EF-hand_7 PF13499.6 ETO35443.1 - 1.8e-14 53.9 10.0 5.2e-08 33.2 3.3 3.4 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_6 PF13405.6 ETO35443.1 - 5.1e-10 38.5 13.4 0.055 13.4 0.2 5.2 5 0 0 5 5 5 4 EF-hand domain EF-hand_8 PF13833.6 ETO35443.1 - 7.8e-10 38.5 4.8 0.054 13.4 0.1 4.9 3 1 1 4 4 4 3 EF-hand domain pair EF-hand_5 PF13202.6 ETO35443.1 - 9.7e-09 34.3 5.7 0.0026 17.2 0.1 4.0 3 0 0 3 3 3 3 EF hand APH PF01636.23 ETO35443.1 - 8.5e-06 25.9 0.1 1.6e-05 25.0 0.1 1.4 1 0 0 1 1 1 1 Phosphotransferase enzyme family RIO1 PF01163.22 ETO35443.1 - 0.00015 21.4 0.2 0.00015 21.4 0.2 1.7 2 0 0 2 2 2 1 RIO1 family Pkinase_fungal PF17667.1 ETO35443.1 - 0.0016 17.3 0.6 0.016 14.0 0.0 2.1 2 0 0 2 2 2 1 Fungal protein kinase YrbL-PhoP_reg PF10707.9 ETO35443.1 - 0.002 17.6 0.0 0.0042 16.6 0.0 1.4 1 0 0 1 1 1 1 PhoP regulatory network protein YrbL Choline_kinase PF01633.20 ETO35443.1 - 0.0035 17.0 0.0 0.0088 15.7 0.0 1.6 1 0 0 1 1 1 1 Choline/ethanolamine kinase Pox_ser-thr_kin PF05445.11 ETO35443.1 - 0.022 13.8 0.3 0.038 13.0 0.3 1.3 1 0 0 1 1 1 0 Poxvirus serine/threonine protein kinase EF-hand_4 PF12763.7 ETO35443.1 - 0.034 14.1 1.0 0.31 11.0 0.2 2.3 1 1 0 2 2 2 0 Cytoskeletal-regulatory complex EF hand IMUP PF15761.5 ETO35443.1 - 0.15 12.8 8.0 0.29 11.8 8.0 1.5 1 0 0 1 1 1 0 Immortalisation up-regulated protein SPARC_Ca_bdg PF10591.9 ETO35443.1 - 0.18 12.1 4.7 3.2 8.1 0.1 3.2 1 1 1 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region CCDC106 PF15794.5 ETO35443.1 - 1.5 8.5 7.2 2.5 7.8 7.2 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 106 SR-25 PF10500.9 ETO35443.1 - 2.7 7.5 24.4 4 7.0 23.6 1.6 1 1 0 1 1 1 0 Nuclear RNA-splicing-associated protein Amidohydro_2 PF04909.14 ETO35444.1 - 6.8e-14 52.3 0.0 1.1e-13 51.6 0.0 1.4 1 0 0 1 1 1 1 Amidohydrolase TatD_DNase PF01026.21 ETO35444.1 - 0.14 11.5 0.0 0.62 9.4 0.0 1.9 2 0 0 2 2 2 0 TatD related DNase NB PF04159.13 ETO35444.1 - 0.29 11.2 3.9 0.8 9.8 3.9 1.7 1 0 0 1 1 1 0 NB glycoprotein DUF3139 PF11337.8 ETO35444.1 - 5.1 7.8 9.1 43 4.9 0.2 3.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) RabGAP-TBC PF00566.18 ETO35445.1 - 4.5e-42 144.1 1.0 4.5e-42 144.1 1.0 3.7 3 1 0 3 3 3 2 Rab-GTPase-TBC domain RCC1 PF00415.18 ETO35445.1 - 8.8e-13 48.7 2.0 7.7e-09 36.0 0.3 2.6 2 0 0 2 2 2 2 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO35445.1 - 2.6e-09 36.6 7.3 4.8e-09 35.8 3.9 2.4 2 0 0 2 2 2 1 Regulator of chromosome condensation (RCC1) repeat Presenilin PF01080.17 ETO35445.1 - 2.7 6.7 10.3 4.6 5.9 10.3 1.3 1 0 0 1 1 1 0 Presenilin Menin PF05053.13 ETO35445.1 - 4.6 5.5 12.2 8.4 4.6 12.2 1.3 1 0 0 1 1 1 0 Menin Sporozoite_P67 PF05642.11 ETO35445.1 - 8.1 4.4 14.1 15 3.5 14.1 1.4 1 0 0 1 1 1 0 Sporozoite P67 surface antigen PRA1 PF03208.19 ETO35446.1 - 2.9e-05 23.7 5.1 3.6e-05 23.4 5.1 1.1 1 0 0 1 1 1 1 PRA1 family protein NhaB PF06450.12 ETO35446.1 - 0.00055 18.9 0.7 0.00067 18.6 0.7 1.0 1 0 0 1 1 1 1 Bacterial Na+/H+ antiporter B (NhaB) DUF3341 PF11821.8 ETO35446.1 - 0.11 12.1 2.7 0.15 11.7 2.7 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF3341) Glyco_transf_22 PF03901.17 ETO35446.1 - 0.46 9.6 5.1 0.58 9.3 5.1 1.1 1 0 0 1 1 1 0 Alg9-like mannosyltransferase family UbiA PF01040.18 ETO35446.1 - 2.4 7.4 11.7 50 3.1 13.4 1.7 1 1 0 1 1 1 0 UbiA prenyltransferase family Promethin PF16015.5 ETO35446.1 - 6.5 6.7 15.1 0.61 10.0 5.5 2.1 2 0 0 2 2 2 0 Promethin Herpes_LMP1 PF05297.11 ETO35446.1 - 9.4 5.3 10.6 3.4 6.8 8.4 1.4 1 1 0 1 1 1 0 Herpesvirus latent membrane protein 1 (LMP1) Kelch_5 PF13854.6 ETO35448.1 - 6.2e-10 38.8 3.2 0.058 13.4 0.1 5.4 5 0 0 5 5 5 3 Kelch motif Kelch_6 PF13964.6 ETO35448.1 - 3.7e-09 36.5 4.1 0.055 13.8 0.0 4.6 4 1 1 5 5 5 3 Kelch motif Kelch_1 PF01344.25 ETO35448.1 - 6.6e-08 32.0 1.6 0.1 12.2 0.0 3.7 3 0 0 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ETO35448.1 - 6.5e-07 29.1 7.5 0.00059 19.7 0.1 4.4 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO35448.1 - 6e-05 23.0 1.7 0.0068 16.4 0.0 3.0 3 0 0 3 3 3 2 Galactose oxidase, central domain WD40 PF00400.32 ETO35449.1 - 1.4e-20 73.2 6.1 5.4e-08 33.4 0.0 6.1 7 1 0 7 7 7 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35449.1 - 4.8e-11 42.8 0.1 0.017 15.4 0.0 5.0 1 1 4 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35449.1 - 8.4e-06 25.0 0.0 0.012 14.6 0.0 3.0 1 1 1 2 2 2 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35449.1 - 8.4e-06 25.3 0.9 0.00087 18.7 0.1 2.7 3 0 0 3 3 3 1 WD40-like domain PD40 PF07676.12 ETO35449.1 - 1.8e-05 24.6 2.0 1.3 9.1 0.0 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO35449.1 - 0.00048 20.1 0.1 1.9 8.4 0.0 3.8 2 1 2 4 4 4 1 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO35449.1 - 0.0025 16.5 0.2 1.7 7.2 0.0 3.0 2 1 1 3 3 3 2 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO35449.1 - 0.027 13.2 0.9 2.8 6.6 0.1 2.5 1 1 1 2 2 2 0 Nup133 N terminal like DUF5570 PF17731.1 ETO35449.1 - 0.086 12.9 0.0 27 4.9 0.0 3.4 3 1 1 4 4 4 0 Family of unknown function (DUF5570) Proteasome_A_N PF10584.9 ETO35449.1 - 2.3 8.0 6.8 5.7 6.7 0.0 3.9 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DnaJ PF00226.31 ETO35450.1 - 4.4e-15 55.6 1.0 6.2e-15 55.1 1.0 1.2 1 0 0 1 1 1 1 DnaJ domain CUE PF02845.16 ETO35451.1 - 0.0045 16.7 0.1 0.012 15.3 0.1 1.7 1 0 0 1 1 1 1 CUE domain PUB PF09409.10 ETO35451.1 - 0.035 14.0 1.8 0.19 11.7 0.3 2.9 1 1 2 3 3 3 0 PUB domain PCI PF01399.27 ETO35451.1 - 0.31 11.6 3.1 0.49 10.9 0.8 2.4 1 1 1 2 2 2 0 PCI domain Kelch_5 PF13854.6 ETO35452.1 - 0.17 11.9 0.0 22 5.1 0.0 2.4 2 0 0 2 2 2 0 Kelch motif Copper-bind PF00127.20 ETO35452.1 - 0.48 10.9 2.4 0.67 10.4 0.3 2.0 1 1 1 2 2 2 0 Copper binding proteins, plastocyanin/azurin family DS PF01916.17 ETO35453.1 - 0.046 13.0 0.1 0.064 12.5 0.1 1.1 1 0 0 1 1 1 0 Deoxyhypusine synthase TPR_12 PF13424.6 ETO35454.1 - 1.8e-14 53.8 0.0 4.9e-06 26.8 0.0 2.1 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35454.1 - 9e-06 25.4 0.0 0.0071 16.2 0.0 2.5 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35454.1 - 1.9e-05 24.3 0.0 0.56 10.4 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35454.1 - 6.3e-05 22.6 0.7 0.36 10.7 0.1 3.2 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35454.1 - 0.0068 16.5 3.6 0.032 14.5 1.6 2.9 3 1 1 4 4 4 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO35454.1 - 0.018 14.5 0.1 0.23 10.9 0.1 2.1 2 0 0 2 2 2 0 SHNi-TPR TPR_11 PF13414.6 ETO35454.1 - 0.052 13.2 0.1 3.5 7.4 0.0 2.3 2 0 0 2 2 2 0 TPR repeat TPR_2 PF07719.17 ETO35454.1 - 0.058 13.5 0.5 3.2 8.1 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Kelch_4 PF13418.6 ETO35456.1 - 6.5e-05 22.9 0.0 0.013 15.5 0.0 2.2 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO35456.1 - 0.00028 20.7 0.6 0.41 10.7 0.1 2.5 2 0 0 2 2 2 2 Kelch motif Kelch_1 PF01344.25 ETO35456.1 - 0.0003 20.3 0.1 0.0032 17.0 0.1 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO35456.1 - 0.0058 16.9 0.0 2.2 8.7 0.0 2.4 2 0 0 2 2 2 2 Kelch motif Kelch_5 PF13854.6 ETO35456.1 - 0.072 13.1 0.0 0.81 9.7 0.0 2.3 2 0 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO35456.1 - 0.17 12.2 0.0 1.2 9.6 0.0 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain WD40 PF00400.32 ETO35457.1 - 0.00033 21.4 0.2 0.0013 19.5 0.2 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF2126 PF09899.9 ETO35458.1 - 0.0035 15.5 0.8 0.0041 15.3 0.8 1.0 1 0 0 1 1 1 1 Putative amidoligase enzyme (DUF2126) Presenilin PF01080.17 ETO35458.1 - 0.0042 15.9 0.7 0.0049 15.7 0.7 1.2 1 0 0 1 1 1 1 Presenilin CLN3 PF02487.17 ETO35458.1 - 0.007 15.5 1.6 0.0089 15.1 1.6 1.3 1 0 0 1 1 1 1 CLN3 protein Zip PF02535.22 ETO35458.1 - 0.0077 15.5 0.7 0.0089 15.3 0.7 1.1 1 0 0 1 1 1 1 ZIP Zinc transporter LAP1C PF05609.12 ETO35458.1 - 0.021 13.9 5.2 0.027 13.6 5.2 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SID-1_RNA_chan PF13965.6 ETO35458.1 - 0.089 11.2 4.8 0.11 10.8 4.8 1.1 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 MDFI PF15316.6 ETO35458.1 - 0.15 12.1 2.1 0.22 11.6 2.1 1.2 1 0 0 1 1 1 0 MyoD family inhibitor RPN2_C PF18004.1 ETO35458.1 - 0.16 11.8 21.4 0.23 11.3 21.4 1.2 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NPR3 PF03666.13 ETO35458.1 - 0.56 8.9 12.0 0.71 8.6 12.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 ALMT PF11744.8 ETO35458.1 - 0.75 8.6 9.3 0.98 8.2 9.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter RR_TM4-6 PF06459.12 ETO35458.1 - 0.85 9.4 14.8 1.2 8.9 14.8 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Peroxin-13_N PF04088.13 ETO35458.1 - 2.1 8.6 14.5 36 4.6 14.5 2.2 1 1 0 1 1 1 0 Peroxin 13, N-terminal region Connexin PF00029.19 ETO35458.1 - 3.5 7.3 17.3 2.6e+02 1.2 17.2 2.1 1 1 0 1 1 1 0 Connexin Ly49 PF08391.10 ETO35458.1 - 3.8 7.9 16.7 8.4 6.8 16.7 1.6 1 0 0 1 1 1 0 Ly49-like protein, N-terminal region Cation_ATPase_C PF00689.21 ETO35459.1 - 1.9e-40 138.5 6.9 3.3e-40 137.7 6.9 1.4 1 0 0 1 1 1 1 Cation transporting ATPase, C-terminus Hydrolase PF00702.26 ETO35459.1 - 9.3e-19 68.5 0.0 1e-16 61.9 0.0 2.8 1 1 0 1 1 1 1 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO35459.1 - 2.1e-13 50.2 0.0 4.8e-13 49.0 0.0 1.6 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETO35459.1 - 0.00021 21.1 1.8 0.023 14.4 0.8 2.3 2 0 0 2 2 2 2 haloacid dehalogenase-like hydrolase Methyltransf_31 PF13847.6 ETO35460.1 - 1.6e-24 86.4 0.0 4.5e-24 85.0 0.0 1.6 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO35460.1 - 8.9e-13 48.8 0.0 2.4e-12 47.4 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO35460.1 - 7.4e-10 39.3 0.0 1.7e-09 38.2 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO35460.1 - 4e-08 32.9 0.0 6.4e-08 32.2 0.0 1.2 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_23 PF13489.6 ETO35460.1 - 5.6e-07 29.5 0.0 7.9e-07 29.1 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO35460.1 - 1.8e-06 28.6 0.0 4e-06 27.5 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain PCMT PF01135.19 ETO35460.1 - 2.3e-05 24.3 0.1 4.2e-05 23.4 0.1 1.4 1 0 0 1 1 1 1 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) FtsJ PF01728.19 ETO35460.1 - 0.0021 18.2 0.0 0.0053 16.9 0.0 1.7 2 0 0 2 2 2 1 FtsJ-like methyltransferase PrmA PF06325.13 ETO35460.1 - 0.0062 16.0 0.0 0.011 15.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) DOT1 PF08123.13 ETO35460.1 - 0.021 14.3 0.2 0.048 13.2 0.1 1.6 2 0 0 2 2 2 0 Histone methylation protein DOT1 Methyltransf_32 PF13679.6 ETO35460.1 - 0.027 14.5 0.1 0.098 12.6 0.0 1.8 2 0 0 2 2 2 0 Methyltransferase domain Methyltransf_8 PF05148.15 ETO35460.1 - 0.084 12.7 0.1 1.5 8.6 0.0 2.1 2 0 0 2 2 2 0 Hypothetical methyltransferase PDR_CDR PF06422.12 ETO35461.1 - 0.013 15.3 0.1 0.035 14.0 0.0 1.7 2 0 0 2 2 2 0 CDR ABC transporter ABC2_membrane PF01061.24 ETO35461.1 - 0.015 14.7 0.3 0.015 14.7 0.3 2.9 3 0 0 3 3 3 0 ABC-2 type transporter WD40 PF00400.32 ETO35462.1 - 1.8e-36 123.5 18.6 6.8e-08 33.1 0.0 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35462.1 - 3.1e-09 37.0 3.4 0.01 16.1 0.5 5.1 1 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35462.1 - 4.4e-08 32.5 1.3 0.76 8.7 0.0 5.0 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35462.1 - 3.4e-06 26.6 0.1 0.00073 18.9 0.1 2.6 2 1 1 3 3 3 2 WD40-like domain PQQ_2 PF13360.6 ETO35462.1 - 0.00014 21.6 2.3 0.01 15.5 2.3 2.4 1 1 0 1 1 1 1 PQQ-like domain Nup160 PF11715.8 ETO35462.1 - 0.00041 19.1 5.9 0.0023 16.7 0.1 3.5 2 2 1 3 3 3 1 Nucleoporin Nup120/160 PQQ PF01011.21 ETO35462.1 - 0.012 15.5 2.5 1.3 9.1 0.2 3.6 4 0 0 4 4 4 0 PQQ enzyme repeat DUF4875 PF16175.5 ETO35462.1 - 0.053 13.7 0.8 3.5 7.8 0.1 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4875) PDCD2_C PF04194.13 ETO35463.1 - 5.9e-28 98.1 17.4 1.9e-21 77.0 11.6 3.1 1 1 1 2 2 2 2 Programmed cell death protein 2, C-terminal putative domain DUF4215 PF13948.6 ETO35463.1 - 0.14 12.7 0.4 0.14 12.7 0.4 4.0 5 0 0 5 5 5 0 Domain of unknown function (DUF4215) Presenilin PF01080.17 ETO35463.1 - 2.2 6.9 4.9 3.1 6.5 4.9 1.1 1 0 0 1 1 1 0 Presenilin GEN1_C PF18380.1 ETO35463.1 - 7.6 7.5 7.8 0.63 11.0 1.4 2.0 2 0 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain Transket_pyr PF02779.24 ETO35464.1 - 4.9e-37 127.3 0.0 7.5e-37 126.7 0.0 1.2 1 0 0 1 1 1 1 Transketolase, pyrimidine binding domain Transketolase_N PF00456.21 ETO35464.1 - 1.9e-15 56.7 0.0 2.9e-15 56.1 0.0 1.3 1 0 0 1 1 1 1 Transketolase, thiamine diphosphate binding domain Transketolase_C PF02780.20 ETO35464.1 - 0.0008 19.3 0.0 0.0021 18.0 0.0 1.7 1 1 0 1 1 1 1 Transketolase, C-terminal domain TMEM43 PF07787.12 ETO35465.1 - 0.045 13.1 0.0 0.045 13.1 0.0 2.0 3 0 0 3 3 3 0 Transmembrane protein 43 WD40 PF00400.32 ETO35466.1 - 3.2e-22 78.4 7.3 1.1e-07 32.4 0.2 4.6 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35466.1 - 6.1e-06 26.4 0.1 0.029 14.6 0.0 2.8 1 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35466.1 - 0.00017 20.4 1.4 0.15 10.7 0.1 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF5530 PF17670.1 ETO35466.1 - 0.023 14.5 0.0 0.77 9.5 0.0 2.3 2 1 0 2 2 2 0 Family of unknown function (DUF5530) Med22 PF06179.12 ETO35467.1 - 0.022 15.0 0.0 0.022 15.0 0.0 2.0 3 0 0 3 3 3 0 Surfeit locus protein 5 subunit 22 of Mediator complex Antirestrict PF03230.13 ETO35467.1 - 0.037 14.1 0.1 3.5 7.7 0.0 2.7 2 0 0 2 2 2 0 Antirestriction protein Mg296 PF09644.10 ETO35467.1 - 0.038 14.1 5.8 0.11 12.6 3.4 2.3 1 1 1 2 2 2 0 Mg296 protein A2M_recep PF07677.14 ETO35467.1 - 0.042 14.5 0.5 0.11 13.2 0.5 1.7 1 0 0 1 1 1 0 A-macroglobulin receptor binding domain NACHT PF05729.12 ETO35468.1 - 4.8e-20 72.1 0.0 3.7e-18 66.0 0.0 3.5 3 0 0 3 3 3 1 NACHT domain HEAT PF02985.22 ETO35468.1 - 8.3e-10 38.1 0.1 0.64 10.4 0.0 7.5 7 0 0 7 7 7 1 HEAT repeat HEAT_2 PF13646.6 ETO35468.1 - 2.7e-08 34.1 0.0 0.0016 18.8 0.0 5.1 4 2 2 6 6 6 2 HEAT repeats NB-ARC PF00931.22 ETO35468.1 - 9.3e-05 21.7 0.3 0.0004 19.6 0.3 2.2 1 0 0 1 1 1 1 NB-ARC domain HEAT_EZ PF13513.6 ETO35468.1 - 0.0031 18.0 0.0 3.8 8.1 0.0 4.3 4 1 1 5 5 5 1 HEAT-like repeat ThiS-like PF14453.6 ETO35468.1 - 0.03 14.4 0.3 1.4 9.0 0.0 3.7 3 0 0 3 3 3 0 ThiS-like ubiquitin AAA_16 PF13191.6 ETO35468.1 - 0.033 14.6 0.0 0.19 12.1 0.0 2.3 3 0 0 3 3 2 0 AAA ATPase domain SRP54_N PF02881.19 ETO35468.1 - 0.035 14.3 4.4 0.56 10.5 1.2 3.1 2 0 0 2 2 2 0 SRP54-type protein, helical bundle domain Ank_2 PF12796.7 ETO35468.1 - 0.051 14.2 1.5 2.8 8.6 0.0 4.6 4 1 0 4 4 4 0 Ankyrin repeats (3 copies) BAG PF02179.16 ETO35468.1 - 0.076 13.5 1.2 5.2 7.6 0.3 3.5 2 0 0 2 2 2 0 BAG domain Ank_3 PF13606.6 ETO35468.1 - 0.14 12.8 0.4 5.2 8.0 0.0 3.9 3 0 0 3 3 2 0 Ankyrin repeat RTP1_C1 PF10363.9 ETO35468.1 - 0.54 10.5 12.6 0.52 10.5 0.4 4.6 3 2 0 3 3 3 0 Required for nuclear transport of RNA pol II C-terminus 1 Vac14_Fab1_bd PF12755.7 ETO35468.1 - 0.64 10.6 7.2 0.75 10.4 0.1 4.5 4 2 0 4 4 3 0 Vacuolar 14 Fab1-binding region NLRC4_HD2 PF17776.1 ETO35468.1 - 0.89 10.1 7.6 0.87 10.1 0.0 4.2 3 1 0 3 3 3 0 NLRC4 helical domain HD2 DUF5071 PF16804.5 ETO35468.1 - 4.5 7.6 15.2 3.2 8.1 0.4 5.5 4 1 1 5 5 5 0 Domain of unknown function (DUF5071) Lig_chan PF00060.26 ETO35470.1 - 0.07 13.0 0.5 0.15 11.9 0.5 1.5 1 0 0 1 1 1 0 Ligand-gated ion channel WD40 PF00400.32 ETO35471.1 - 0.0086 16.9 0.0 0.018 15.9 0.0 1.5 1 0 0 1 1 1 1 WD domain, G-beta repeat PfUIS3 PF11567.8 ETO35471.1 - 0.019 15.3 1.7 0.073 13.4 0.2 2.1 1 1 1 2 2 2 0 Plasmodium falciparum UIS3 membrane protein Phage_int_SAM_4 PF13495.6 ETO35471.1 - 0.027 14.9 0.9 0.027 14.9 0.9 1.7 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain DUF2247 PF10004.9 ETO35472.1 - 0.0028 17.5 0.1 0.0065 16.3 0.1 1.6 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2247) YceD PF02620.17 ETO35472.1 - 0.1 12.7 0.1 0.1 12.7 0.1 2.6 3 0 0 3 3 3 0 Large ribosomal RNA subunit accumulation protein YceD Kelch_1 PF01344.25 ETO35473.1 - 1.1e-05 24.9 0.3 0.00031 20.3 0.2 2.3 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO35473.1 - 0.0013 18.6 0.5 0.077 13.0 0.2 2.5 2 0 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO35473.1 - 0.0017 18.3 0.1 0.026 14.5 0.0 2.2 1 1 1 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO35473.1 - 0.0053 17.0 2.0 0.16 12.4 0.2 2.5 1 1 1 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO35473.1 - 0.2 11.7 2.2 2.3 8.3 0.4 2.4 2 0 0 2 2 2 0 Kelch motif PE-PPE PF08237.11 ETO35474.1 - 0.063 12.8 0.0 0.16 11.5 0.0 1.5 1 1 1 2 2 2 0 PE-PPE domain DUF520 PF04461.13 ETO35474.1 - 0.07 13.2 0.5 0.086 13.0 0.5 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF520) RRM_1 PF00076.22 ETO35476.1 - 5.4e-08 32.5 0.0 9.6e-08 31.7 0.0 1.4 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) FlxA PF14282.6 ETO35477.1 - 1.5 8.9 21.1 0.12 12.4 5.2 3.3 2 1 1 3 3 3 0 FlxA-like protein Tubulin PF00091.25 ETO35478.1 - 4e-13 50.0 0.1 6.4e-13 49.3 0.1 1.3 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO35478.1 - 6.9e-06 26.2 0.0 1.3e-05 25.3 0.0 1.4 1 0 0 1 1 1 1 Tubulin C-terminal domain PDZ_6 PF17820.1 ETO35479.1 - 1.1e-07 31.6 0.0 1.6e-07 31.1 0.0 1.3 1 0 0 1 1 1 1 PDZ domain PDZ PF00595.24 ETO35479.1 - 4.6e-06 26.9 0.0 7.7e-06 26.2 0.0 1.4 1 0 0 1 1 1 1 PDZ domain PDZ_2 PF13180.6 ETO35479.1 - 1.6e-05 25.1 0.0 2.2e-05 24.7 0.0 1.2 1 0 0 1 1 1 1 PDZ domain Pkinase PF00069.25 ETO35480.1 - 0.00034 20.1 2.2 0.00064 19.2 2.2 1.5 1 1 0 1 1 1 1 Protein kinase domain DUF4446 PF14584.6 ETO35482.1 - 0.0072 16.3 3.7 0.0072 16.3 3.7 7.8 5 3 6 11 11 11 3 Protein of unknown function (DUF4446) zf-C5HC2 PF02928.16 ETO35482.1 - 0.034 14.5 0.6 0.097 13.1 0.6 1.8 1 0 0 1 1 1 0 C5HC2 zinc finger Baculo_PEP_C PF04513.12 ETO35482.1 - 0.037 14.1 0.5 0.037 14.1 0.5 5.8 3 2 1 5 5 5 0 Baculovirus polyhedron envelope protein, PEP, C terminus FUSC PF04632.12 ETO35482.1 - 1.1 7.7 10.9 0.091 11.3 0.3 2.9 1 1 3 4 4 4 0 Fusaric acid resistance protein family TolA_bind_tri PF16331.5 ETO35483.1 - 0.38 10.8 12.3 8.8 6.5 0.6 5.0 3 1 2 5 5 5 0 TolA binding protein trimerisation Baculo_PEP_C PF04513.12 ETO35483.1 - 0.58 10.2 7.0 2.6 8.1 0.2 3.4 1 1 3 4 4 4 0 Baculovirus polyhedron envelope protein, PEP, C terminus LSM PF01423.22 ETO35484.1 - 9.6e-06 25.2 0.2 2e-05 24.2 0.2 1.6 1 0 0 1 1 1 1 LSM domain Ras PF00071.22 ETO35486.1 - 1.4e-54 184.0 2.2 2.6e-35 121.4 0.2 2.1 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO35486.1 - 3.1e-30 104.9 1.1 6.5e-15 55.4 0.1 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO35486.1 - 2.5e-11 43.3 0.6 1.2e-07 31.4 0.0 2.1 2 0 0 2 2 2 2 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO35486.1 - 1.3e-06 28.1 0.2 2.6e-06 27.1 0.2 1.5 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO35486.1 - 0.00051 20.1 0.0 0.00091 19.3 0.0 1.6 1 0 0 1 1 1 1 50S ribosome-binding GTPase RsgA_GTPase PF03193.16 ETO35486.1 - 0.0018 18.2 0.1 0.1 12.5 0.0 2.4 2 0 0 2 2 2 1 RsgA GTPase AAA_7 PF12775.7 ETO35486.1 - 0.016 14.7 0.3 0.035 13.6 0.0 1.7 2 0 0 2 2 2 0 P-loop containing dynein motor region Hpr_kinase_C PF07475.12 ETO35486.1 - 0.022 14.3 0.1 4.1 6.9 0.0 2.6 3 0 0 3 3 3 0 HPr Serine kinase C-terminal domain AAA_22 PF13401.6 ETO35486.1 - 0.026 14.8 0.4 0.079 13.2 0.2 2.2 1 1 1 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO35486.1 - 0.048 13.4 0.0 0.12 12.1 0.0 1.7 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_16 PF13191.6 ETO35486.1 - 0.08 13.3 0.1 0.14 12.5 0.0 1.6 2 1 0 2 2 2 0 AAA ATPase domain TniB PF05621.11 ETO35486.1 - 0.085 12.2 0.2 0.66 9.3 0.0 2.0 2 0 0 2 2 2 0 Bacterial TniB protein ABC_tran PF00005.27 ETO35486.1 - 0.15 12.6 1.3 0.31 11.6 1.3 1.9 1 1 0 1 1 1 0 ABC transporter DUF2514 PF10721.9 ETO35487.1 - 3.5 7.6 7.6 20 5.2 0.1 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF2514) PXT1 PF15214.6 ETO35487.1 - 9.4 6.7 6.2 20 5.6 0.2 3.3 3 1 1 4 4 4 0 Peroxisomal testis-specific protein 1 ACR_tran PF00873.19 ETO35488.1 - 0.41 8.2 1.8 0.62 7.6 1.8 1.3 1 0 0 1 1 1 0 AcrB/AcrD/AcrF family IL15 PF02372.15 ETO35488.1 - 3 7.8 8.6 0.65 10.0 1.5 2.5 1 1 1 2 2 2 0 Interleukin 15 LAP1C PF05609.12 ETO35490.1 - 0.011 14.9 10.9 0.014 14.6 10.9 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PA26 PF04636.13 ETO35490.1 - 0.019 13.9 4.5 0.025 13.5 4.5 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) GREB1 PF15782.5 ETO35490.1 - 0.17 9.0 10.7 0.21 8.7 10.7 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer EMC3_TMCO1 PF01956.16 ETO35490.1 - 1.6 8.4 8.8 0.12 12.1 0.6 2.2 2 0 0 2 2 2 0 Integral membrane protein EMC3/TMCO1-like TraF PF13728.6 ETO35490.1 - 2.2 8.1 6.9 4.1 7.2 6.9 1.6 1 1 0 1 1 1 0 F plasmid transfer operon protein SpoIIIAH PF12685.7 ETO35490.1 - 3.3 7.5 10.2 6.3 6.6 10.2 1.4 1 0 0 1 1 1 0 SpoIIIAH-like protein ABC_export PF16962.5 ETO35491.1 - 0.0018 16.8 0.2 0.0018 16.8 0.2 1.2 1 0 0 1 1 1 1 Putative ABC exporter CDC45 PF02724.14 ETO35491.1 - 0.025 12.9 5.4 0.025 12.9 5.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO35491.1 - 0.043 12.6 5.6 0.046 12.5 5.6 1.1 1 0 0 1 1 1 0 Presenilin SelP_N PF04592.14 ETO35491.1 - 0.093 12.1 5.3 0.11 11.9 5.3 1.1 1 0 0 1 1 1 0 Selenoprotein P, N terminal region NPR3 PF03666.13 ETO35491.1 - 0.099 11.4 9.4 0.12 11.1 9.4 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Ctr PF04145.15 ETO35491.1 - 0.22 12.2 1.3 0.31 11.6 1.3 1.3 1 0 0 1 1 1 0 Ctr copper transporter family CPSF100_C PF13299.6 ETO35491.1 - 0.79 9.9 7.6 1.2 9.3 7.6 1.4 1 1 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 ETO35491.1 - 1.1 8.2 3.5 1.3 8.0 3.5 1.1 1 0 0 1 1 1 0 CLN3 protein Connexin PF00029.19 ETO35491.1 - 2.8 7.6 8.4 4.6 6.9 8.4 1.4 1 1 0 1 1 1 0 Connexin TB2_DP1_HVA22 PF03134.19 ETO35492.1 - 0.24 11.3 10.4 0.29 11.1 2.5 2.5 3 0 0 3 3 3 0 TB2/DP1, HVA22 family AAA_5 PF07728.14 ETO35493.1 - 0.0031 17.5 0.3 0.015 15.3 0.0 2.4 3 0 0 3 3 3 1 AAA domain (dynein-related subfamily) Rad17 PF03215.15 ETO35493.1 - 0.024 14.6 0.0 0.041 13.8 0.0 1.4 1 0 0 1 1 1 0 Rad17 P-loop domain AAA_22 PF13401.6 ETO35493.1 - 0.069 13.4 0.5 0.68 10.2 0.0 2.4 1 1 1 2 2 2 0 AAA domain AAA PF00004.29 ETO35493.1 - 0.13 12.7 0.0 0.88 10.0 0.0 2.2 2 0 0 2 2 2 0 ATPase family associated with various cellular activities (AAA) Tubulin PF00091.25 ETO35494.1 - 1.2e-50 172.5 0.0 1.5e-50 172.1 0.0 1.1 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Lipase_3 PF01764.25 ETO35494.1 - 0.033 14.1 0.0 0.057 13.3 0.0 1.4 1 0 0 1 1 1 0 Lipase (class 3) Pkinase PF00069.25 ETO35497.1 - 2.6e-23 82.8 0.1 3.1e-23 82.5 0.1 1.0 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35497.1 - 5.5e-11 42.2 0.1 6.4e-11 42.0 0.1 1.0 1 0 0 1 1 1 1 Protein tyrosine kinase Ldi PF18566.1 ETO35498.1 - 3.4e-09 36.6 0.4 8.3e-09 35.4 0.4 1.7 1 0 0 1 1 1 1 Linalool dehydratase/isomerase DUF1963 PF09234.10 ETO35498.1 - 0.017 15.6 0.3 0.034 14.6 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1963) NST1 PF13945.6 ETO35498.1 - 0.78 9.8 9.5 3.8 7.6 0.8 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator SprT-like PF10263.9 ETO35499.1 - 0.00021 21.1 0.1 0.00059 19.7 0.1 1.8 1 0 0 1 1 1 1 SprT-like family BPL_LplA_LipB PF03099.19 ETO35500.1 - 0.0019 18.1 0.0 0.04 13.8 0.0 2.4 1 1 0 1 1 1 1 Biotin/lipoate A/B protein ligase family OTCace PF00185.24 ETO35501.1 - 1.3e-39 135.8 0.4 3.2e-39 134.5 0.0 1.9 2 0 0 2 2 2 1 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain AA_kinase PF00696.28 ETO35501.1 - 3.6e-28 98.8 0.2 5.9e-28 98.1 0.2 1.4 1 0 0 1 1 1 1 Amino acid kinase family DUF3328 PF11807.8 ETO35502.1 - 0.47 10.2 1.9 0.55 10.0 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) Jiraiya PF15038.6 ETO35504.1 - 0.13 11.7 0.8 0.19 11.2 0.8 1.3 1 0 0 1 1 1 0 Jiraiya VWC PF00093.18 ETO35505.1 - 5.1 7.5 12.2 0.17 12.3 4.8 2.3 2 1 0 2 2 2 0 von Willebrand factor type C domain zf-HC5HC2H_2 PF13832.6 ETO35507.1 - 6.9e-13 48.7 18.4 4.3e-08 33.3 11.5 3.6 2 1 1 3 3 3 2 PHD-zinc-finger like domain PHD_2 PF13831.6 ETO35507.1 - 4.6e-09 35.7 2.1 4.6e-09 35.7 2.1 2.5 2 0 0 2 2 2 1 PHD-finger zf-HC5HC2H PF13771.6 ETO35507.1 - 2.2e-08 34.3 21.6 0.00014 22.0 4.1 4.2 3 1 0 4 4 4 3 PHD-like zinc-binding domain PHD PF00628.29 ETO35507.1 - 1.8e-05 24.5 6.2 1.8e-05 24.5 6.2 3.4 4 0 0 4 4 4 2 PHD-finger TIM PF00121.18 ETO35508.1 - 6.9e-79 264.7 0.8 1.5e-78 263.5 0.8 1.5 1 1 0 1 1 1 1 Triosephosphate isomerase baeRF_family6 PF18848.1 ETO35508.1 - 0.14 12.6 0.0 0.23 11.8 0.0 1.3 1 0 0 1 1 1 0 Bacterial archaeo-eukaryotic release factor family 6 PUF PF00806.19 ETO35509.1 - 4.7e-24 82.7 5.3 0.0001 21.8 0.0 6.6 6 0 0 6 6 6 5 Pumilio-family RNA binding repeat CPL PF08144.11 ETO35509.1 - 0.0013 19.1 1.5 0.93 9.8 0.2 4.3 3 2 0 3 3 3 1 CPL (NUC119) domain Ribosomal_S6 PF01250.17 ETO35509.1 - 0.041 14.1 2.6 25 5.2 0.0 4.4 5 0 0 5 5 5 0 Ribosomal protein S6 IF4E PF01652.18 ETO35510.1 - 2.9e-05 23.9 1.5 7.7e-05 22.5 1.5 1.7 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF2142 PF09913.9 ETO35510.1 - 0.029 13.2 0.2 0.069 12.0 0.2 1.5 1 0 0 1 1 1 0 Predicted membrane protein (DUF2142) RGS PF00615.19 ETO35510.1 - 0.04 14.2 1.5 0.094 13.0 0.3 2.2 2 0 0 2 2 2 0 Regulator of G protein signaling domain Zn_ribbon_17 PF17120.5 ETO35510.1 - 0.1 12.3 0.7 0.27 10.9 0.7 1.7 1 0 0 1 1 1 0 Zinc-ribbon, C4HC2 type DUF3122 PF11320.8 ETO35511.1 - 0.07 13.2 1.6 0.56 10.3 0.4 2.4 2 0 0 2 2 2 0 Protein of unknown function (DUF3122) F420_oxidored PF03807.17 ETO35512.1 - 9.7e-20 71.0 0.8 3.9e-19 69.0 0.8 1.8 1 1 0 1 1 1 1 NADP oxidoreductase coenzyme F420-dependent NAD_binding_2 PF03446.15 ETO35512.1 - 6.2e-07 29.7 0.0 1e-06 29.0 0.0 1.3 1 0 0 1 1 1 1 NAD binding domain of 6-phosphogluconate dehydrogenase NAD_Gly3P_dh_N PF01210.23 ETO35512.1 - 7e-07 29.3 0.0 9.1e-07 29.0 0.0 1.3 1 0 0 1 1 1 1 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus ApbA PF02558.16 ETO35512.1 - 3.4e-05 23.5 0.1 4.7e-05 23.1 0.1 1.2 1 0 0 1 1 1 1 Ketopantoate reductase PanE/ApbA Rossmann-like PF10727.9 ETO35512.1 - 8e-05 22.5 1.2 0.012 15.5 0.1 2.1 1 1 1 2 2 2 2 Rossmann-like domain IlvN PF07991.12 ETO35512.1 - 0.00027 20.6 0.4 0.0035 16.9 0.4 2.0 1 1 0 1 1 1 1 Acetohydroxy acid isomeroreductase, NADPH-binding domain 2-Hacid_dh_C PF02826.19 ETO35512.1 - 0.00042 19.7 0.3 0.0016 17.8 0.3 1.9 1 1 0 1 1 1 1 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain 3HCDH_N PF02737.18 ETO35512.1 - 0.00077 19.4 0.4 0.0014 18.5 0.4 1.5 1 1 0 1 1 1 1 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ETO35512.1 - 0.00085 19.7 0.1 0.0012 19.2 0.1 1.1 1 0 0 1 1 1 1 Putative NAD(P)-binding PDH PF02153.17 ETO35512.1 - 0.00099 18.2 0.2 0.015 14.3 0.1 2.0 1 1 1 2 2 2 1 Prephenate dehydrogenase UDPG_MGDP_dh_N PF03721.14 ETO35512.1 - 0.0027 17.3 0.4 0.0087 15.6 0.4 1.8 1 1 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain UDPG_MGDP_dh_C PF03720.15 ETO35512.1 - 0.0089 16.4 0.0 0.011 16.1 0.0 1.2 1 0 0 1 1 1 1 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain NmrA PF05368.13 ETO35512.1 - 0.033 13.8 0.2 0.045 13.3 0.2 1.2 1 0 0 1 1 1 0 NmrA-like family TrkA_N PF02254.18 ETO35512.1 - 0.093 13.0 0.0 1.1 9.5 0.0 2.1 2 0 0 2 2 2 0 TrkA-N domain Shikimate_DH PF01488.20 ETO35512.1 - 0.12 12.4 0.1 0.95 9.5 0.1 2.0 1 1 0 1 1 1 0 Shikimate / quinate 5-dehydrogenase Staph_opine_DH PF10100.9 ETO35512.1 - 0.17 10.5 0.0 0.22 10.1 0.0 1.1 1 0 0 1 1 1 0 Staphylopine dehydrogenase LacAB_rpiB PF02502.18 ETO35513.1 - 0.1 12.6 0.4 0.18 11.8 0.4 1.4 1 1 0 1 1 1 0 Ribose/Galactose Isomerase adh_short PF00106.25 ETO35514.1 - 1.6e-25 89.8 0.0 1e-22 80.5 0.0 3.6 3 1 0 3 3 3 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO35514.1 - 1.6e-13 50.7 0.0 1.4e-10 41.1 0.0 3.2 2 1 0 2 2 2 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO35514.1 - 1.4e-09 38.1 0.0 6.3e-09 36.0 0.0 1.9 2 0 0 2 2 2 1 KR domain Epimerase PF01370.21 ETO35514.1 - 0.00036 20.1 0.0 0.0042 16.6 0.0 2.1 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family Nrap_D3 PF17404.2 ETO35515.1 - 1e-13 51.7 3.5 4.8e-13 49.5 0.1 2.5 2 0 0 2 2 2 1 Nrap protein domain 3 Nrap_D5 PF17406.2 ETO35515.1 - 2.5e-10 40.4 0.0 8.5e-10 38.6 0.0 1.9 1 0 0 1 1 1 1 Nrap protein PAP/OAS1-like domain 5 Nrap_D4 PF17405.2 ETO35515.1 - 3.6e-10 39.6 0.1 8.8e-10 38.3 0.1 1.6 1 0 0 1 1 1 1 Nrap protein nucleotidyltransferase domain 4 DUF3446 PF11928.8 ETO35515.1 - 0.083 13.2 19.0 0.32 11.3 1.9 3.7 3 0 0 3 3 3 0 Early growth response N-terminal domain SMYLE_N PF18615.1 ETO35518.1 - 0.11 12.1 1.8 0.13 11.8 1.8 1.0 1 0 0 1 1 1 0 Short myomegalin-like EB1 binding proteins, N-terminal domain DUF498 PF04430.14 ETO35520.1 - 0.084 13.0 0.0 0.1 12.6 0.0 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF498/DUF598) p450 PF00067.22 ETO35521.1 - 4e-54 184.1 2.4 2.7e-53 181.4 0.5 2.0 2 0 0 2 2 2 1 Cytochrome P450 TRP PF06011.12 ETO35521.1 - 0.047 12.4 0.5 0.072 11.8 0.5 1.2 1 0 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF3413 PF11893.8 ETO35521.1 - 0.09 11.9 0.6 0.15 11.2 0.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3413) SLATT_4 PF18186.1 ETO35521.1 - 0.12 12.0 0.2 3.2 7.4 0.1 2.4 2 0 0 2 2 2 0 SMODS and SLOG-associating 2TM effector domain family 4 G-alpha PF00503.20 ETO35522.1 - 3.5e-71 240.2 7.5 3.4e-64 217.3 3.5 2.0 2 0 0 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO35522.1 - 2.8e-08 33.4 0.3 0.00017 21.1 0.0 2.3 2 0 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO35522.1 - 0.041 14.0 0.1 3.5 7.7 0.0 2.4 2 0 0 2 2 2 0 50S ribosome-binding GTPase AAA_18 PF13238.6 ETO35522.1 - 0.068 13.7 0.0 0.46 11.0 0.0 2.3 2 0 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO35522.1 - 0.069 12.9 0.6 0.31 10.8 0.5 2.1 1 1 0 1 1 1 0 P-loop containing region of AAA domain Roc PF08477.13 ETO35522.1 - 0.083 13.1 1.1 1.6 9.0 0.1 2.6 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase ABC_tran PF00005.27 ETO35522.1 - 0.19 12.2 0.4 0.58 10.7 0.4 1.7 1 1 0 1 1 1 0 ABC transporter AAA_21 PF13304.6 ETO35522.1 - 0.19 11.5 1.3 0.71 9.6 1.3 2.0 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system Gtr1_RagA PF04670.12 ETO35522.1 - 0.87 8.9 4.3 9.1 5.5 0.1 2.5 2 1 0 2 2 2 0 Gtr1/RagA G protein conserved region FATC PF02260.20 ETO35523.1 - 0.069 13.0 0.0 0.19 11.6 0.0 1.8 1 0 0 1 1 1 0 FATC domain Sulfotransfer_3 PF13469.6 ETO35524.1 - 9.5e-15 55.6 2.1 4.6e-12 46.8 0.1 2.7 3 0 0 3 3 3 2 Sulfotransferase family Sulfotransfer_1 PF00685.27 ETO35524.1 - 0.0013 18.3 3.2 0.0038 16.8 3.2 1.8 1 1 0 1 1 1 1 Sulfotransferase domain RNA_pol_I_A49 PF06870.12 ETO35525.1 - 0.00033 19.7 0.0 0.00059 18.8 0.0 1.4 1 0 0 1 1 1 1 A49-like RNA polymerase I associated factor Mss4 PF04421.13 ETO35525.1 - 0.0042 17.2 0.1 0.0042 17.2 0.1 2.8 4 0 0 4 4 4 1 Mss4 protein RGS PF00615.19 ETO35526.1 - 0.00014 22.1 0.2 0.00014 22.1 0.2 2.2 3 0 0 3 3 3 1 Regulator of G protein signaling domain Protoglobin PF11563.8 ETO35526.1 - 0.06 13.2 0.1 0.13 12.2 0.1 1.5 1 0 0 1 1 1 0 Protoglobin RhoGAP PF00620.27 ETO35527.1 - 2.6e-11 43.5 0.0 3.6e-11 43.1 0.0 1.1 1 0 0 1 1 1 1 RhoGAP domain PBD PF00786.28 ETO35527.1 - 0.02 15.2 0.1 0.072 13.5 0.0 2.1 2 1 0 2 2 2 0 P21-Rho-binding domain SCFA_trans PF02667.14 ETO35528.1 - 1.3 7.9 5.2 1 8.3 3.6 1.5 1 1 1 2 2 2 0 Short chain fatty acid transporter MDM10 PF12519.8 ETO35530.1 - 0.17 10.7 3.2 0.18 10.6 3.2 1.0 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 NPR3 PF03666.13 ETO35530.1 - 0.99 8.1 8.3 0.95 8.2 8.3 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Connexin PF00029.19 ETO35530.1 - 1 9.1 5.5 1 9.1 5.5 1.2 1 0 0 1 1 1 0 Connexin TAF4 PF05236.14 ETO35530.1 - 1.7 8.3 13.2 1.9 8.2 13.2 1.1 1 0 0 1 1 1 0 Transcription initiation factor TFIID component TAF4 family Exo_endo_phos_2 PF14529.6 ETO35534.1 - 9.1e-06 25.5 2.4 1.7e-05 24.7 0.7 2.0 1 1 0 2 2 2 1 Endonuclease-reverse transcriptase RNase_H PF00075.24 ETO35534.1 - 0.0086 16.3 0.0 0.028 14.6 0.0 1.7 2 0 0 2 2 2 1 RNase H Exo_endo_phos PF03372.23 ETO35534.1 - 0.12 11.9 0.3 0.16 11.5 0.2 1.4 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family Ntox21 PF15526.6 ETO35535.1 - 0.024 15.0 0.6 0.28 11.5 0.3 2.2 2 0 0 2 2 2 0 Novel toxin 21 zf-RING_9 PF13901.6 ETO35536.1 - 8.1e-12 45.5 6.1 1.3e-09 38.4 1.0 3.3 2 1 0 3 3 3 2 Putative zinc-RING and/or ribbon FYVE PF01363.21 ETO35536.1 - 5 7.3 9.3 37 4.5 3.9 3.4 2 2 1 3 3 3 0 FYVE zinc finger PARP PF00644.20 ETO35537.1 - 4.2e-12 46.1 0.2 4.2e-12 46.1 0.2 2.2 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain BUD22 PF09073.10 ETO35537.1 - 0.00057 19.3 5.6 0.00057 19.3 5.6 2.2 2 0 0 2 2 2 1 BUD22 RNA_pol_3_Rpc31 PF11705.8 ETO35537.1 - 4.4 7.5 25.7 1.9 8.7 17.5 2.5 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 NAD_binding_8 PF13450.6 ETO35538.1 - 1.7e-12 47.4 1.1 2.7e-12 46.7 1.1 1.3 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETO35538.1 - 5.2e-09 35.7 0.2 6.5e-09 35.4 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain DAO PF01266.24 ETO35538.1 - 2e-06 27.6 0.3 2.5e-06 27.3 0.3 1.1 1 0 0 1 1 1 1 FAD dependent oxidoreductase FAD_oxidored PF12831.7 ETO35538.1 - 3.8e-06 26.5 0.1 5.5e-06 26.0 0.1 1.2 1 0 0 1 1 1 1 FAD dependent oxidoreductase Amino_oxidase PF01593.24 ETO35538.1 - 4.3e-06 26.3 0.1 5.2e-06 26.0 0.1 1.1 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Pyr_redox_2 PF07992.14 ETO35538.1 - 1.4e-05 24.5 0.2 3e-05 23.4 0.1 1.3 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Thi4 PF01946.17 ETO35538.1 - 5.2e-05 22.6 0.1 6e-05 22.4 0.1 1.1 1 0 0 1 1 1 1 Thi4 family HI0933_like PF03486.14 ETO35538.1 - 0.00011 21.1 0.1 0.00014 20.7 0.1 1.2 1 0 0 1 1 1 1 HI0933-like protein Pyr_redox PF00070.27 ETO35538.1 - 0.00024 21.6 0.1 0.00051 20.6 0.1 1.6 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO35538.1 - 0.0015 17.8 0.2 0.002 17.5 0.2 1.2 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase GIDA PF01134.22 ETO35538.1 - 0.0017 17.5 0.2 0.0024 17.0 0.2 1.2 1 0 0 1 1 1 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ETO35538.1 - 0.0033 16.7 0.2 0.0045 16.3 0.2 1.1 1 0 0 1 1 1 1 FAD binding domain MCRA PF06100.11 ETO35538.1 - 0.039 12.8 0.4 0.085 11.6 0.1 1.6 1 1 1 2 2 2 0 MCRA family AlaDh_PNT_C PF01262.21 ETO35538.1 - 0.043 13.1 0.0 0.056 12.7 0.0 1.2 1 0 0 1 1 1 0 Alanine dehydrogenase/PNT, C-terminal domain Lycopene_cycl PF05834.12 ETO35538.1 - 0.14 11.2 0.1 0.18 10.8 0.1 1.1 1 0 0 1 1 1 0 Lycopene cyclase protein GDI PF00996.18 ETO35538.1 - 0.15 10.6 0.1 0.21 10.0 0.1 1.2 1 0 0 1 1 1 0 GDP dissociation inhibitor Pkinase PF00069.25 ETO35540.1 - 4e-47 160.8 0.1 5e-47 160.5 0.1 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35540.1 - 1.1e-21 77.3 0.0 1.4e-21 77.0 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Kdo PF06293.14 ETO35540.1 - 0.00014 21.2 0.0 0.00024 20.5 0.0 1.3 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO35540.1 - 0.025 14.5 0.0 0.039 13.9 0.0 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Kinase-like PF14531.6 ETO35540.1 - 0.036 13.4 0.0 0.053 12.8 0.0 1.2 1 0 0 1 1 1 0 Kinase-like FTA2 PF13095.6 ETO35540.1 - 0.037 13.7 0.0 0.053 13.1 0.0 1.3 1 0 0 1 1 1 0 Kinetochore Sim4 complex subunit FTA2 Haspin_kinase PF12330.8 ETO35540.1 - 0.065 12.2 0.1 0.2 10.6 0.0 1.6 1 1 0 1 1 1 0 Haspin like kinase domain PRT_C PF08372.10 ETO35541.1 - 0.064 13.0 0.0 0.12 12.1 0.0 1.4 1 0 0 1 1 1 0 Plant phosphoribosyltransferase C-terminal ATP-synt_DE_N PF02823.16 ETO35542.1 - 5.7e-12 45.4 0.0 8.1e-12 44.9 0.0 1.2 1 0 0 1 1 1 1 ATP synthase, Delta/Epsilon chain, beta-sandwich domain Peptidase_C54 PF03416.19 ETO35543.1 - 6.8e-31 107.7 0.2 1.5e-30 106.6 0.2 1.6 1 0 0 1 1 1 1 Peptidase family C54 PTPRCAP PF15713.5 ETO35543.1 - 0.0018 18.6 28.1 0.028 14.7 13.3 2.4 2 0 0 2 2 2 2 Protein tyrosine phosphatase receptor type C-associated CDC45 PF02724.14 ETO35543.1 - 0.0021 16.4 30.6 0.043 12.1 13.9 2.1 2 0 0 2 2 2 2 CDC45-like protein BSP_II PF05432.11 ETO35543.1 - 0.0034 17.1 15.4 0.0034 17.1 15.4 2.6 3 0 0 3 3 3 1 Bone sialoprotein II (BSP-II) DUF2457 PF10446.9 ETO35543.1 - 0.0089 15.2 14.7 0.0089 15.2 14.7 2.8 3 1 0 3 3 3 1 Protein of unknown function (DUF2457) Mpp10 PF04006.12 ETO35543.1 - 0.023 13.2 28.6 0.11 10.9 10.4 2.2 2 0 0 2 2 2 0 Mpp10 protein SDA1 PF05285.12 ETO35543.1 - 0.029 13.8 29.7 0.5 9.7 9.8 2.3 2 0 0 2 2 2 0 SDA1 Nop14 PF04147.12 ETO35543.1 - 0.37 9.0 32.2 0.097 10.9 9.0 2.1 2 0 0 2 2 2 0 Nop14-like family Apt1 PF10351.9 ETO35543.1 - 2.9 6.6 24.1 0.38 9.6 8.2 2.3 2 0 0 2 2 2 0 Golgi-body localisation protein domain Presenilin PF01080.17 ETO35543.1 - 8.5 5.0 26.9 1.3 7.8 10.9 2.3 2 0 0 2 2 2 0 Presenilin DZR PF12773.7 ETO35544.1 - 5.2e-08 32.8 25.3 0.12 12.4 0.3 5.5 3 1 2 5 5 5 5 Double zinc ribbon zf-GRF PF06839.12 ETO35544.1 - 8.1e-07 29.0 11.1 3.1 8.0 0.0 6.0 5 0 0 5 5 5 2 GRF zinc finger DUF4428 PF14471.6 ETO35544.1 - 1.4e-06 28.1 14.7 0.26 11.3 0.4 5.3 5 0 0 5 5 5 4 Domain of unknown function (DUF4428) Mcm10 PF09332.11 ETO35544.1 - 2.8e-05 23.7 22.4 0.0034 16.9 0.1 5.0 5 0 0 5 5 5 3 Mcm10 replication factor zf_UBZ PF18439.1 ETO35544.1 - 6.6e-05 22.4 22.3 3.2 7.4 0.2 6.7 7 0 0 7 7 7 4 Ubiquitin-Binding Zinc Finger Sgf11 PF08209.11 ETO35544.1 - 9.8e-05 21.8 30.3 0.36 10.4 0.3 6.7 7 0 0 7 7 7 4 Sgf11 (transcriptional regulation protein) Zn_Tnp_IS91 PF14319.6 ETO35544.1 - 0.00014 21.8 32.6 0.35 10.9 0.8 5.2 2 1 1 5 5 5 4 Transposase zinc-binding domain MafB19-deam PF14437.6 ETO35544.1 - 0.0028 17.4 0.7 3.5 7.4 0.0 4.0 4 0 0 4 4 4 1 MafB19-like deaminase DUF3797 PF12677.7 ETO35544.1 - 0.004 17.0 18.6 10 6.1 0.0 5.7 5 0 0 5 5 5 0 Domain of unknown function (DUF3797) DUF730 PF05325.11 ETO35544.1 - 0.055 13.5 8.4 21 5.2 0.0 4.7 4 1 0 4 4 4 0 Protein of unknown function (DUF730) zf-C3HC4_3 PF13920.6 ETO35544.1 - 0.12 12.3 30.7 0.26 11.2 0.2 7.2 9 0 0 9 9 7 0 Zinc finger, C3HC4 type (RING finger) Me-amine-dh_L PF02975.14 ETO35544.1 - 0.14 12.6 36.6 1.7 9.2 1.6 5.4 2 2 3 5 5 5 0 Methylamine dehydrogenase, L chain CpXC PF14353.6 ETO35544.1 - 0.17 12.0 17.8 3.6 7.6 0.1 5.7 4 2 0 5 5 5 0 CpXC protein Mut7-C PF01927.16 ETO35544.1 - 0.21 11.7 30.3 0.82 9.8 0.2 5.9 1 1 4 5 5 5 0 Mut7-C RNAse domain ComFB PF10719.9 ETO35544.1 - 0.28 11.3 1.7 2.3e+02 2.0 0.0 4.6 5 1 0 5 5 5 0 Late competence development protein ComFB zf_Rg PF17915.1 ETO35544.1 - 0.99 8.9 18.4 1.4 8.4 0.1 5.2 5 0 0 5 5 5 0 Reverse gyrase zinc finger Ribosomal_S27e PF01667.17 ETO35544.1 - 1.3 8.8 20.1 5 6.9 0.6 5.2 5 0 0 5 5 5 0 Ribosomal protein S27 Prok-RING_4 PF14447.6 ETO35544.1 - 1.3 8.9 18.8 9 6.2 1.0 6.2 6 1 0 6 6 6 0 Prokaryotic RING finger family 4 Cys_rich_KTR PF14205.6 ETO35544.1 - 1.8 8.4 17.4 44 4.0 0.1 5.7 5 0 0 5 5 5 0 Cysteine-rich KTR DnaJ_CXXCXGXG PF00684.19 ETO35544.1 - 1.9 8.9 27.8 16 5.9 7.3 5.3 2 2 2 4 4 4 0 DnaJ central domain Acetone_carb_G PF08882.11 ETO35544.1 - 2.1 8.5 6.3 3.1 8.0 0.2 3.8 5 0 0 5 5 5 0 Acetone carboxylase gamma subunit zf_C2H2_10 PF18414.1 ETO35544.1 - 2.2 7.9 28.9 8.9 6.0 0.4 5.4 5 0 0 5 5 5 0 C2H2 type zinc-finger ADD_DNMT3 PF17980.1 ETO35544.1 - 4 7.5 18.4 41 4.3 0.2 5.6 5 1 0 5 5 5 0 Cysteine rich ADD domain in DNMT3 TF_Zn_Ribbon PF08271.12 ETO35544.1 - 6.2 6.4 34.0 3.9 7.1 0.4 6.6 6 2 0 6 6 6 0 TFIIB zinc-binding Sgf11 PF08209.11 ETO35545.1 - 0.031 13.8 0.1 0.057 13.0 0.1 1.4 1 0 0 1 1 1 0 Sgf11 (transcriptional regulation protein) TPR_12 PF13424.6 ETO35546.1 - 8.3e-21 74.1 0.1 2e-10 40.8 0.0 3.3 2 1 1 3 3 3 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35546.1 - 3.8e-14 51.8 6.0 7.4e-06 25.6 0.1 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35546.1 - 9.7e-10 37.8 0.1 0.0084 16.1 0.0 4.0 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35546.1 - 4.1e-09 35.9 2.1 0.016 15.3 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35546.1 - 1.7e-08 34.0 6.0 0.022 14.9 0.1 4.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35546.1 - 1.3e-06 28.0 0.0 0.096 12.6 0.0 4.1 4 0 0 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO35546.1 - 1.9e-06 27.8 1.9 0.032 14.3 0.3 3.6 3 0 0 3 3 3 2 MIT (microtubule interacting and transport) domain Peptidase_C14 PF00656.22 ETO35546.1 - 7.7e-06 26.0 2.8 4.1e-05 23.6 0.9 2.2 1 1 1 2 2 2 1 Caspase domain TPR_6 PF13174.6 ETO35546.1 - 0.0086 16.7 0.2 1.5 9.6 0.1 3.4 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO35546.1 - 0.057 14.3 0.0 26 6.0 0.0 3.3 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO35546.1 - 0.058 13.2 5.1 0.11 12.3 0.7 3.0 3 1 1 4 4 4 0 Domain of unknown function (DUF5113) TPR_3 PF07720.12 ETO35546.1 - 0.58 10.2 6.4 5.2 7.2 0.1 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF5523 PF17661.1 ETO35547.1 - 0.021 14.5 8.2 0.024 14.3 8.2 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF5523) Pox_Ag35 PF03286.14 ETO35547.1 - 0.041 13.7 7.7 0.046 13.5 7.7 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Orf78 PF06024.12 ETO35547.1 - 0.085 13.2 3.4 0.13 12.6 3.1 1.4 1 1 0 1 1 1 0 Orf78 (ac78) DUF2407_C PF13373.6 ETO35547.1 - 0.087 13.0 1.0 0.2 11.9 0.5 1.8 1 1 1 2 2 2 0 DUF2407 C-terminal domain DUF913 PF06025.12 ETO35547.1 - 0.098 11.6 2.1 0.11 11.4 2.1 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) CDC45 PF02724.14 ETO35547.1 - 0.13 10.6 9.4 0.15 10.3 9.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Connexin PF00029.19 ETO35547.1 - 0.15 11.8 2.1 0.19 11.5 2.1 1.2 1 0 0 1 1 1 0 Connexin RPA43_OB PF17875.1 ETO35547.1 - 0.19 12.4 2.5 0.27 11.9 2.5 1.2 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I Zip PF02535.22 ETO35547.1 - 0.23 10.7 2.1 0.25 10.5 2.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter PTPRCAP PF15713.5 ETO35547.1 - 0.4 11.0 9.4 0.67 10.2 9.4 1.3 1 0 0 1 1 1 0 Protein tyrosine phosphatase receptor type C-associated CSG2 PF16965.5 ETO35547.1 - 0.47 9.3 2.0 0.54 9.1 2.0 1.1 1 0 0 1 1 1 0 Ceramide synthase regulator Presenilin PF01080.17 ETO35547.1 - 0.73 8.5 3.2 0.82 8.4 3.2 1.1 1 0 0 1 1 1 0 Presenilin NOA36 PF06524.12 ETO35547.1 - 0.88 8.8 12.6 1.1 8.5 12.6 1.1 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ETO35547.1 - 1.6 8.3 7.0 2.5 7.7 7.0 1.4 1 0 0 1 1 1 0 FAM176 family Actin PF00022.19 ETO35548.1 - 7.9e-15 54.4 0.0 8.3e-15 54.3 0.0 1.0 1 0 0 1 1 1 1 Actin WD40 PF00400.32 ETO35549.1 - 1.2e-33 114.5 23.3 5e-07 30.3 0.1 6.7 6 1 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35549.1 - 1.3e-08 35.0 1.1 0.0075 16.5 0.0 4.7 3 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35549.1 - 1.9e-07 30.1 4.6 0.49 9.0 0.1 4.6 1 1 3 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO35549.1 - 0.012 15.7 1.7 18 5.4 0.2 4.7 3 2 1 4 4 4 0 Ciliary BBSome complex subunit 2, middle region Methyltransf_23 PF13489.6 ETO35551.1 - 0.0018 18.2 0.0 0.0027 17.5 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO35551.1 - 0.009 16.7 0.3 0.13 12.9 0.3 2.5 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO35551.1 - 0.02 15.7 0.0 0.053 14.3 0.0 1.8 1 1 0 1 1 1 0 Methyltransferase domain Ubie_methyltran PF01209.18 ETO35551.1 - 0.022 14.1 0.0 0.038 13.3 0.0 1.3 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family FtsJ PF01728.19 ETO35551.1 - 0.031 14.4 0.0 0.071 13.2 0.0 1.5 1 1 0 1 1 1 0 FtsJ-like methyltransferase Methyltransf_31 PF13847.6 ETO35551.1 - 0.077 12.8 0.4 2.6 7.8 0.0 2.6 3 0 0 3 3 3 0 Methyltransferase domain SAM_2 PF07647.17 ETO35552.1 - 1.8e-10 40.7 2.5 1.1e-07 31.9 0.4 2.9 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO35552.1 - 2.9e-10 40.4 4.0 2.5e-07 31.0 0.2 2.5 2 0 0 2 2 2 2 SAM domain (Sterile alpha motif) TMEM208_SND2 PF05620.11 ETO35552.1 - 0.032 14.0 0.0 0.032 14.0 0.0 2.5 3 0 0 3 3 3 0 SRP-independent targeting protein 2/TMEM208 SR-25 PF10500.9 ETO35552.1 - 3.2 7.3 14.7 0.14 11.7 8.3 2.0 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein ANAPC3 PF12895.7 ETO35553.1 - 0.0001 22.5 0.6 0.023 14.9 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETO35553.1 - 0.00016 21.5 1.4 0.022 14.9 0.1 2.8 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35553.1 - 0.0011 18.9 0.0 0.06 13.4 0.0 2.4 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35553.1 - 0.0013 18.6 0.3 0.0045 16.8 0.0 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_12 PF13424.6 ETO35553.1 - 0.035 14.4 0.6 0.15 12.4 0.0 2.1 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_19 PF14559.6 ETO35553.1 - 0.086 13.4 0.0 1.8 9.2 0.0 2.2 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35553.1 - 0.18 11.7 2.7 0.23 11.3 0.1 2.4 3 0 0 3 3 3 0 Tetratricopeptide repeat Kinesin PF00225.23 ETO35554.1 - 3.3e-49 167.6 5.2 7.8e-25 87.5 0.4 2.5 2 0 0 2 2 2 2 Kinesin motor domain DUF1156 PF06634.12 ETO35554.1 - 0.098 12.8 0.1 0.28 11.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF1156) PNISR PF15996.5 ETO35556.1 - 0.0047 17.2 4.3 0.0068 16.7 4.3 1.1 1 0 0 1 1 1 1 Arginine/serine-rich protein PNISR Sec62 PF03839.16 ETO35556.1 - 0.16 11.4 5.8 3.3 7.2 2.3 2.6 2 0 0 2 2 2 0 Translocation protein Sec62 CDC45 PF02724.14 ETO35556.1 - 0.27 9.5 8.4 0.39 8.9 8.4 1.1 1 0 0 1 1 1 0 CDC45-like protein Renin_r PF07850.14 ETO35556.1 - 2.3 8.9 0.0 2.3 8.9 0.0 4.3 5 0 0 5 5 5 0 Renin receptor-like protein LRR_8 PF13855.6 ETO35557.1 - 1.7e-07 30.9 13.1 2e-05 24.2 0.8 4.5 2 2 3 5 5 5 3 Leucine rich repeat LRR_4 PF12799.7 ETO35557.1 - 0.00029 21.2 1.8 0.00029 21.2 1.8 3.2 2 1 1 3 3 3 1 Leucine Rich repeats (2 copies) LRR_9 PF14580.6 ETO35557.1 - 0.0025 17.3 4.4 0.0083 15.6 0.6 2.5 1 1 2 3 3 3 2 Leucine-rich repeat PIH1 PF08190.12 ETO35557.1 - 0.056 12.9 0.2 0.11 12.0 0.2 1.4 1 0 0 1 1 1 0 PIH1 N-terminal domain Moulting_cycle PF04870.16 ETO35558.1 - 0.0014 18.0 3.0 0.0021 17.4 3.0 1.2 1 0 0 1 1 1 1 Moulting cycle V-SNARE PF05008.15 ETO35558.1 - 0.0071 16.7 0.9 0.015 15.6 0.9 1.6 1 0 0 1 1 1 1 Vesicle transport v-SNARE protein N-terminus Use1 PF09753.9 ETO35558.1 - 0.02 14.6 3.5 0.026 14.2 3.5 1.1 1 0 0 1 1 1 0 Membrane fusion protein Use1 DUF2489 PF10675.9 ETO35558.1 - 0.022 14.7 0.2 0.051 13.5 0.2 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF2489) Kre28 PF17097.5 ETO35558.1 - 0.044 12.7 6.7 0.051 12.5 6.7 1.2 1 0 0 1 1 1 0 Spindle pole body component KxDL PF10241.9 ETO35558.1 - 0.099 12.9 0.7 0.099 12.9 0.7 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein Mod_r PF07200.13 ETO35558.1 - 0.19 11.9 5.1 0.24 11.5 5.1 1.3 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein Uso1_p115_C PF04871.13 ETO35558.1 - 0.36 11.2 4.9 1.2 9.5 3.4 2.3 1 1 0 1 1 1 0 Uso1 / p115 like vesicle tethering protein, C terminal region Rtf2 PF04641.12 ETO35561.1 - 0.0035 16.8 7.1 0.0047 16.3 7.1 1.1 1 0 0 1 1 1 1 Rtf2 RING-finger Phage_connect_1 PF05135.13 ETO35561.1 - 0.054 14.0 0.3 0.1 13.1 0.3 1.5 1 0 0 1 1 1 0 Phage gp6-like head-tail connector protein Ferlin_C PF16165.5 ETO35561.1 - 1.5 8.7 5.8 7.7 6.4 1.2 2.2 2 0 0 2 2 2 0 Ferlin C-terminus WD40 PF00400.32 ETO35563.1 - 5.2e-65 213.8 26.9 6.9e-10 39.4 0.3 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35563.1 - 7.3e-24 83.9 6.6 7.6e-05 22.9 0.1 6.9 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35563.1 - 9e-15 54.4 0.1 0.07 12.1 0.0 6.1 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35563.1 - 2.2e-10 40.4 0.2 0.0093 15.3 0.0 4.2 1 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO35563.1 - 6.6e-10 38.2 3.9 0.51 8.9 0.0 5.7 1 1 3 6 6 6 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO35563.1 - 4e-08 33.0 6.9 0.39 10.7 0.0 6.3 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO35563.1 - 1.8e-07 31.3 1.3 5.3 7.2 0.0 5.0 1 1 4 5 5 5 3 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO35563.1 - 1.9e-06 26.7 0.7 0.00088 17.9 0.0 2.9 1 1 2 3 3 3 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO35563.1 - 0.00041 19.2 0.1 0.065 12.0 0.0 3.2 1 1 2 3 3 3 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Peptidase_S9_N PF02897.15 ETO35563.1 - 0.00061 18.7 0.7 0.0022 16.9 0.7 2.0 1 1 0 1 1 1 1 Prolyl oligopeptidase, N-terminal beta-propeller domain Proteasome_A_N PF10584.9 ETO35563.1 - 0.0052 16.4 3.0 34 4.3 0.0 5.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature PQQ PF01011.21 ETO35563.1 - 0.0099 15.8 0.0 38 4.4 0.0 4.8 5 0 0 5 5 5 0 PQQ enzyme repeat Nbas_N PF15492.6 ETO35563.1 - 0.01 15.2 2.1 3.8 6.8 0.1 3.5 1 1 3 4 4 4 0 Neuroblastoma-amplified sequence, N terminal DUF4265 PF14085.6 ETO35563.1 - 0.067 13.2 0.2 2.2 8.3 0.0 3.2 3 2 1 4 4 4 0 Domain of unknown function (DUF4265) NHL PF01436.21 ETO35563.1 - 0.17 12.0 1.0 1.5 9.0 0.1 3.1 3 0 0 3 3 2 0 NHL repeat CoA_trans PF01144.23 ETO35564.1 - 1.6e-36 125.8 0.0 2e-36 125.4 0.0 1.1 1 0 0 1 1 1 1 Coenzyme A transferase 7TMR-DISM_7TM PF07695.11 ETO35564.1 - 0.0072 16.2 0.2 0.012 15.5 0.2 1.2 1 0 0 1 1 1 1 7TM diverse intracellular signalling AcetylCoA_hyd_C PF13336.6 ETO35564.1 - 0.012 15.6 0.1 0.02 14.8 0.1 1.3 1 0 0 1 1 1 0 Acetyl-CoA hydrolase/transferase C-terminal domain CoA_trans PF01144.23 ETO35565.1 - 2.4e-52 177.5 0.2 1.5e-51 174.9 0.2 1.9 1 1 0 1 1 1 1 Coenzyme A transferase PNK3P PF08645.11 ETO35567.1 - 0.1 12.3 0.3 0.2 11.4 0.3 1.4 1 0 0 1 1 1 0 Polynucleotide kinase 3 phosphatase zf-CCHC PF00098.23 ETO35568.1 - 0.22 11.6 5.6 0.23 11.6 0.1 2.7 2 0 0 2 2 2 0 Zinc knuckle PPR_3 PF13812.6 ETO35571.1 - 9.5e-05 22.4 1.0 1.2 9.3 0.0 4.2 4 1 0 4 4 4 2 Pentatricopeptide repeat domain PPR PF01535.20 ETO35571.1 - 0.011 16.0 0.3 26 5.4 0.0 3.8 4 0 0 4 4 4 0 PPR repeat PPR_2 PF13041.6 ETO35571.1 - 0.013 15.7 0.1 0.21 11.8 0.1 3.0 2 1 0 2 2 2 0 PPR repeat family SHNi-TPR PF10516.9 ETO35571.1 - 0.043 13.3 0.5 0.15 11.6 0.1 2.1 2 0 0 2 2 2 0 SHNi-TPR PPR_1 PF12854.7 ETO35571.1 - 0.047 13.4 7.0 7.8 6.3 0.1 4.7 5 0 0 5 5 5 0 PPR repeat PPR_2 PF13041.6 ETO35572.1 - 9.8e-06 25.7 0.1 0.17 12.1 0.0 2.8 2 1 0 2 2 2 2 PPR repeat family PPR PF01535.20 ETO35572.1 - 0.0054 16.9 4.8 0.46 10.9 0.0 3.6 4 0 0 4 4 4 2 PPR repeat Abhydrolase_3 PF07859.13 ETO35573.1 - 4.4e-17 62.6 0.0 2.8e-16 60.0 0.0 2.1 1 1 0 1 1 1 1 alpha/beta hydrolase fold Say1_Mug180 PF10340.9 ETO35573.1 - 4.9e-08 32.2 4.1 1e-07 31.2 0.5 2.1 2 0 0 2 2 2 1 Steryl acetyl hydrolase COesterase PF00135.28 ETO35573.1 - 0.036 13.0 0.1 6.2 5.6 0.0 2.1 2 0 0 2 2 2 0 Carboxylesterase family DHHC PF01529.20 ETO35573.1 - 1.1 9.4 6.3 0.2 11.7 0.5 2.2 2 0 0 2 2 2 0 DHHC palmitoyltransferase Beach PF02138.18 ETO35574.1 - 1.5e-60 205.0 2.6 1.9e-58 198.1 0.1 2.2 2 0 0 2 2 2 2 Beige/BEACH domain WD40 PF00400.32 ETO35574.1 - 1.4e-11 44.8 17.3 1.8e-07 31.7 0.3 5.1 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35574.1 - 0.00034 20.8 1.1 0.1 12.9 0.1 3.3 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain FTCD_C PF04961.12 ETO35575.1 - 0.021 14.6 0.4 0.036 13.8 0.3 1.4 1 1 0 1 1 1 0 Formiminotransferase-cyclodeaminase Nop14 PF04147.12 ETO35576.1 - 0.00013 20.4 12.6 0.00019 19.9 12.6 1.2 1 0 0 1 1 1 1 Nop14-like family CDC45 PF02724.14 ETO35576.1 - 0.00014 20.4 8.4 0.00015 20.2 8.4 1.1 1 0 0 1 1 1 1 CDC45-like protein Afi1 PF07792.12 ETO35576.1 - 0.0076 16.7 3.3 0.0076 16.7 3.3 1.8 2 1 0 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking RNA_pol_3_Rpc31 PF11705.8 ETO35576.1 - 0.017 15.4 10.5 0.017 15.4 10.5 2.0 2 1 0 2 2 1 0 DNA-directed RNA polymerase III subunit Rpc31 Med7 PF05983.11 ETO35576.1 - 0.042 13.9 0.4 0.07 13.2 0.4 1.3 1 0 0 1 1 1 0 MED7 protein YL1 PF05764.13 ETO35576.1 - 0.086 12.9 20.4 0.16 12.1 20.4 1.4 1 1 0 1 1 1 0 YL1 nuclear protein DUF4611 PF15387.6 ETO35576.1 - 0.09 13.0 10.2 0.29 11.4 10.2 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Sigma70_ner PF04546.13 ETO35576.1 - 0.13 12.1 9.3 0.29 11.0 9.3 1.6 1 0 0 1 1 1 0 Sigma-70, non-essential region DUF2722 PF10846.8 ETO35576.1 - 0.27 10.1 6.0 0.36 9.7 6.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2722) RXT2_N PF08595.11 ETO35576.1 - 0.28 11.2 8.8 0.67 10.0 8.8 1.7 1 0 0 1 1 1 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 ETO35576.1 - 0.6 8.2 19.9 0.96 7.5 19.9 1.3 1 0 0 1 1 1 0 DNA polymerase phi RRN3 PF05327.11 ETO35576.1 - 0.77 8.2 9.6 1.1 7.7 9.6 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 TRAP_alpha PF03896.16 ETO35576.1 - 0.78 8.9 4.6 1.6 7.8 4.6 1.6 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit Nop53 PF07767.11 ETO35576.1 - 1.1 8.6 12.6 0.41 10.0 9.9 1.6 2 0 0 2 2 2 0 Nop53 (60S ribosomal biogenesis) eIF-3c_N PF05470.12 ETO35576.1 - 2 6.7 9.0 2.6 6.2 9.0 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus SIR4_SID PF16991.5 ETO35576.1 - 2.1 8.4 7.5 5.1 7.1 7.5 1.6 1 0 0 1 1 1 0 Sir4 SID domain Sporozoite_P67 PF05642.11 ETO35576.1 - 3.9 5.4 6.4 6.1 4.8 6.4 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen CobT PF06213.12 ETO35576.1 - 4.1 6.7 12.4 6.1 6.2 12.4 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF4637 PF15470.6 ETO35576.1 - 6.6 6.4 12.1 14 5.4 12.1 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) Pes-10 PF07149.11 ETO35576.1 - 7.3 5.5 12.8 11 5.0 12.8 1.2 1 0 0 1 1 1 0 Pes-10 DUF1298 PF06974.13 ETO35577.1 - 0.0029 17.5 0.0 0.011 15.7 0.0 1.9 2 0 0 2 2 2 1 Protein of unknown function (DUF1298) Phage_sheath_1C PF17482.2 ETO35577.1 - 0.024 14.6 0.4 1.1 9.3 0.1 2.8 2 2 0 2 2 2 0 Phage tail sheath C-terminal domain Rad17 PF03215.15 ETO35579.1 - 2.6e-08 34.0 0.1 6.1e-05 23.0 0.0 3.2 3 0 0 3 3 3 1 Rad17 P-loop domain AAA PF00004.29 ETO35579.1 - 2.8e-07 31.0 0.0 7.7e-07 29.6 0.0 1.8 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_18 PF13238.6 ETO35579.1 - 2.1e-05 25.1 0.3 9.1e-05 23.0 0.0 2.3 2 1 0 2 2 2 1 AAA domain RuvB_N PF05496.12 ETO35579.1 - 7.8e-05 22.5 0.0 0.00015 21.5 0.0 1.4 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETO35579.1 - 0.0002 21.8 0.0 0.00057 20.3 0.0 1.7 1 0 0 1 1 1 1 AAA ATPase domain Zeta_toxin PF06414.12 ETO35579.1 - 0.0018 17.6 0.0 0.0031 16.8 0.0 1.4 1 0 0 1 1 1 1 Zeta toxin AAA_5 PF07728.14 ETO35579.1 - 0.0029 17.6 0.0 0.0094 15.9 0.0 1.9 1 0 0 1 1 1 1 AAA domain (dynein-related subfamily) AAA_28 PF13521.6 ETO35579.1 - 0.003 17.8 0.0 0.014 15.6 0.0 2.2 2 0 0 2 2 2 1 AAA domain AAA_33 PF13671.6 ETO35579.1 - 0.0045 17.1 0.0 0.01 16.0 0.0 1.6 1 0 0 1 1 1 1 AAA domain AAA_25 PF13481.6 ETO35579.1 - 0.008 15.8 0.0 0.016 14.8 0.0 1.5 1 0 0 1 1 1 1 AAA domain TsaE PF02367.17 ETO35579.1 - 0.011 15.7 0.0 0.022 14.7 0.0 1.5 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE SKI PF01202.22 ETO35579.1 - 0.012 15.8 0.0 0.74 9.9 0.0 2.7 2 0 0 2 2 2 0 Shikimate kinase AAA_17 PF13207.6 ETO35579.1 - 0.014 15.9 0.2 0.064 13.7 0.0 2.2 2 0 0 2 2 1 0 AAA domain NACHT PF05729.12 ETO35579.1 - 0.017 15.1 0.0 0.042 13.8 0.0 1.7 1 0 0 1 1 1 0 NACHT domain RNA_helicase PF00910.22 ETO35579.1 - 0.017 15.5 0.0 0.072 13.5 0.0 2.1 1 0 0 1 1 1 0 RNA helicase NTPase_1 PF03266.15 ETO35579.1 - 0.019 14.9 0.1 0.076 12.9 0.0 2.0 2 0 0 2 2 2 0 NTPase AAA_24 PF13479.6 ETO35579.1 - 0.041 13.6 0.2 0.29 10.8 0.0 2.4 3 0 0 3 3 3 0 AAA domain TIP49 PF06068.13 ETO35579.1 - 0.042 13.1 0.0 0.087 12.0 0.0 1.5 1 0 0 1 1 1 0 TIP49 P-loop domain Mg_chelatase PF01078.21 ETO35579.1 - 0.054 12.9 0.0 0.11 11.8 0.0 1.5 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI Ribosomal_L32p PF01783.23 ETO35579.1 - 0.055 13.7 0.3 0.25 11.6 0.3 2.1 1 0 0 1 1 1 0 Ribosomal L32p protein family ABC_tran PF00005.27 ETO35579.1 - 0.074 13.6 0.0 0.074 13.6 0.0 2.5 3 1 0 3 3 3 0 ABC transporter ATPase PF06745.13 ETO35579.1 - 0.077 12.3 0.1 0.77 9.1 0.0 2.1 2 0 0 2 2 2 0 KaiC AAA_22 PF13401.6 ETO35579.1 - 0.09 13.0 0.0 0.27 11.5 0.0 1.8 1 0 0 1 1 1 0 AAA domain AAA_23 PF13476.6 ETO35579.1 - 0.14 12.6 0.0 0.14 12.6 0.0 2.9 2 1 0 2 2 1 0 AAA domain AAA_29 PF13555.6 ETO35579.1 - 0.15 11.8 0.0 0.35 10.6 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF3545 PF12065.8 ETO35579.1 - 0.19 11.8 0.2 0.19 11.8 0.2 2.8 3 0 0 3 3 3 0 Protein of unknown function (DUF3545) AAA_11 PF13086.6 ETO35579.1 - 0.28 10.9 0.1 0.28 10.9 0.1 2.9 1 1 1 2 2 1 0 AAA domain PEX11 PF05648.14 ETO35579.1 - 0.73 9.2 3.0 1.3 8.4 1.4 2.1 1 1 1 2 2 2 0 Peroxisomal biogenesis factor 11 (PEX11) RFC1 PF08519.12 ETO35580.1 - 0.0068 16.6 0.3 0.082 13.1 0.0 2.7 2 1 0 2 2 2 1 Replication factor RFC1 C terminal domain AAA PF00004.29 ETO35580.1 - 0.044 14.2 0.0 0.13 12.7 0.0 1.8 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) Chorein_N PF12624.7 ETO35581.1 - 7.8e-08 32.4 1.8 1.3e-07 31.7 1.8 1.7 1 1 0 1 1 1 1 N-terminal region of Chorein or VPS13 NOA36 PF06524.12 ETO35581.1 - 0.15 11.4 5.6 0.17 11.2 5.6 1.1 1 0 0 1 1 1 0 NOA36 protein PBP1_TM PF14812.6 ETO35581.1 - 0.34 11.3 8.2 0.48 10.8 8.2 1.3 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Yippee-Mis18 PF03226.14 ETO35582.1 - 1.4e-12 47.7 4.9 3.5e-12 46.4 4.9 1.7 1 0 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly BUD22 PF09073.10 ETO35582.1 - 2.5 7.4 75.4 0.38 10.1 36.4 2.1 2 0 0 2 2 2 0 BUD22 WD40 PF00400.32 ETO35583.1 - 2.3e-08 34.5 0.3 0.0032 18.3 0.0 3.8 4 1 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35583.1 - 0.00035 20.8 0.2 0.44 10.9 0.0 3.3 1 1 3 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Rad51 PF08423.11 ETO35584.1 - 1.6e-28 99.6 0.0 3e-13 49.6 0.0 2.1 1 1 0 2 2 2 2 Rad51 DnaB_C PF03796.15 ETO35584.1 - 2.2e-05 23.9 0.1 0.00029 20.2 0.1 2.2 1 1 0 1 1 1 1 DnaB-like helicase C terminal domain ATPase PF06745.13 ETO35584.1 - 7.5e-05 22.2 1.2 0.00018 20.9 0.1 2.1 2 1 1 3 3 3 1 KaiC AAA_25 PF13481.6 ETO35584.1 - 9.6e-05 22.0 0.0 0.00036 20.2 0.0 2.0 1 1 0 1 1 1 1 AAA domain PSY3 PF16836.5 ETO35584.1 - 0.016 14.7 1.1 0.028 14.0 0.9 1.5 1 1 0 1 1 1 0 Shu complex component Psy3, DNA-binding description AAA_33 PF13671.6 ETO35584.1 - 0.026 14.7 0.0 0.053 13.7 0.0 1.6 1 0 0 1 1 1 0 AAA domain RecA PF00154.21 ETO35584.1 - 0.091 12.2 0.1 0.29 10.5 0.0 1.7 2 0 0 2 2 2 0 recA bacterial DNA recombination protein DUF682 PF05081.12 ETO35584.1 - 0.11 12.2 2.7 0.18 11.5 2.7 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF682) Leader_CPA1 PF08252.11 ETO35584.1 - 0.16 11.4 0.1 0.16 11.4 0.1 2.0 2 0 0 2 2 2 0 arg-2/CPA1 leader peptide AAA_22 PF13401.6 ETO35584.1 - 0.19 12.0 0.7 4.3 7.6 0.7 2.7 1 1 0 1 1 1 0 AAA domain Cor1 PF04803.12 ETO35584.1 - 0.37 11.0 4.5 7.2 6.8 0.2 2.9 2 1 1 3 3 3 0 Cor1/Xlr/Xmr conserved region DUF3458_C PF17432.2 ETO35585.1 - 1.5e-65 221.7 0.0 1.9e-65 221.4 0.0 1.1 1 0 0 1 1 1 1 Domain of unknown function (DUF3458_C) ARM repeats U-box PF04564.15 ETO35587.1 - 3.5e-14 52.7 0.1 5.8e-14 52.0 0.1 1.4 1 0 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO35587.1 - 0.013 15.7 0.0 0.024 14.7 0.0 1.4 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein zf-Nse PF11789.8 ETO35587.1 - 0.014 15.2 0.0 0.035 13.9 0.0 1.6 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-TRAF PF02176.18 ETO35588.1 - 7.5e-06 26.5 2.4 1.1e-05 26.0 0.8 2.2 2 0 0 2 2 2 1 TRAF-type zinc finger zf-MIZ PF02891.20 ETO35588.1 - 2.3 8.0 9.3 0.68 9.7 3.5 3.0 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger ThiF PF00899.21 ETO35590.1 - 1.4e-19 70.5 0.0 2e-19 69.9 0.0 1.4 1 1 0 1 1 1 1 ThiF family E2_bind PF08825.10 ETO35590.1 - 1e-12 48.0 0.0 1.9e-12 47.1 0.0 1.4 1 0 0 1 1 1 1 E2 binding domain UAE_UbL PF14732.6 ETO35590.1 - 0.0019 18.7 0.0 0.0036 17.9 0.0 1.4 1 0 0 1 1 1 1 Ubiquitin/SUMO-activating enzyme ubiquitin-like domain WD40 PF00400.32 ETO35591.1 - 6.3e-06 26.8 0.3 1.8e-05 25.4 0.3 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat Nup160 PF11715.8 ETO35591.1 - 0.00029 19.6 0.1 0.00034 19.4 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35591.1 - 0.03 14.6 0.1 0.059 13.7 0.0 1.6 1 1 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain ApoLp-III PF07464.11 ETO35592.1 - 0.019 15.0 16.8 0.084 13.0 0.2 2.9 3 0 0 3 3 3 0 Apolipophorin-III precursor (apoLp-III) DUF1330 PF07045.11 ETO35592.1 - 0.069 13.5 0.7 0.66 10.4 0.0 2.8 3 0 0 3 3 3 0 Domain of unknown function (DUF1330) DUF3810 PF12725.7 ETO35593.1 - 0.012 14.9 3.7 0.019 14.3 3.7 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF3810) TMEM223 PF14640.6 ETO35593.1 - 0.41 10.8 3.8 0.12 12.5 0.8 1.6 2 0 0 2 2 2 0 Transmembrane protein 223 HIRAN PF08797.11 ETO35594.1 - 7.2e-07 29.1 0.0 1.6e-06 28.0 0.0 1.6 1 0 0 1 1 1 1 HIRAN domain End3 PF12761.7 ETO35594.1 - 0.062 13.5 6.3 0.12 12.6 6.3 1.4 1 0 0 1 1 1 0 Actin cytoskeleton-regulatory complex protein END3 DUF3888 PF13027.6 ETO35594.1 - 0.2 12.1 4.3 2.5 8.6 4.4 2.5 1 1 0 1 1 1 0 Protein of unknown function (DUF3888) TFIID_20kDa PF03847.13 ETO35595.1 - 0.053 14.0 0.1 0.053 14.0 0.1 2.7 2 0 0 2 2 2 0 Transcription initiation factor TFIID subunit A Stork_head PF10264.9 ETO35595.1 - 0.1 12.8 0.9 0.3 11.3 0.1 2.2 2 0 0 2 2 2 0 Winged helix Storkhead-box1 domain DUF2052 PF09747.9 ETO35597.1 - 0.002 18.3 15.3 0.0024 18.0 15.3 1.0 1 0 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) Tankyrase_bdg_C PF15327.6 ETO35597.1 - 0.043 14.3 10.4 0.049 14.1 10.4 1.0 1 0 0 1 1 1 0 Tankyrase binding protein C terminal domain RR_TM4-6 PF06459.12 ETO35597.1 - 0.049 13.4 15.7 0.056 13.3 15.7 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Zip PF02535.22 ETO35597.1 - 0.057 12.6 7.5 0.061 12.5 7.5 1.0 1 0 0 1 1 1 0 ZIP Zinc transporter RP-C_C PF11800.8 ETO35597.1 - 0.13 12.4 10.2 0.15 12.1 10.2 1.1 1 0 0 1 1 1 0 Replication protein C C-terminal region Rtf2 PF04641.12 ETO35597.1 - 0.22 10.8 16.7 0.22 10.8 16.7 1.1 1 0 0 1 1 1 0 Rtf2 RING-finger TRAP_alpha PF03896.16 ETO35597.1 - 0.23 10.6 6.9 0.26 10.4 6.9 1.3 1 0 0 1 1 1 0 Translocon-associated protein (TRAP), alpha subunit RNA_pol_Rpc4 PF05132.14 ETO35597.1 - 0.25 11.8 11.6 0.37 11.2 11.6 1.3 1 0 0 1 1 1 0 RNA polymerase III RPC4 DUF913 PF06025.12 ETO35597.1 - 0.25 10.3 9.3 0.29 10.1 9.3 1.0 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) EOS1 PF12326.8 ETO35597.1 - 0.28 11.1 4.5 0.33 10.9 4.5 1.1 1 0 0 1 1 1 0 N-glycosylation protein V_ATPase_I PF01496.19 ETO35597.1 - 0.29 9.0 11.0 0.3 9.0 11.0 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Presenilin PF01080.17 ETO35597.1 - 0.36 9.5 15.9 0.41 9.3 15.9 1.0 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO35597.1 - 0.37 9.5 16.9 0.42 9.3 16.9 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 PBP1_TM PF14812.6 ETO35597.1 - 0.48 10.8 12.9 0.77 10.2 12.9 1.2 1 0 0 1 1 1 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Vfa1 PF08432.10 ETO35597.1 - 0.59 10.4 19.8 0.8 10.0 19.8 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 DUF2201_N PF13203.6 ETO35597.1 - 0.75 9.3 6.7 0.82 9.2 6.7 1.1 1 0 0 1 1 1 0 Putative metallopeptidase domain FancD2 PF14631.6 ETO35597.1 - 0.76 7.1 11.2 0.81 7.0 11.2 1.0 1 0 0 1 1 1 0 Fanconi anaemia protein FancD2 nuclease PPP4R2 PF09184.11 ETO35597.1 - 0.78 9.3 20.2 0.86 9.1 20.2 1.0 1 0 0 1 1 1 0 PPP4R2 Paf1 PF03985.13 ETO35597.1 - 0.79 8.7 22.8 0.91 8.5 22.8 1.0 1 0 0 1 1 1 0 Paf1 PPL5 PF18168.1 ETO35597.1 - 0.81 8.9 11.3 1 8.6 11.3 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Tim54 PF11711.8 ETO35597.1 - 0.83 8.4 14.9 0.97 8.2 14.9 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 XRN_M PF17846.1 ETO35597.1 - 0.85 8.5 13.3 0.91 8.4 13.3 1.0 1 0 0 1 1 1 0 Xrn1 helical domain DUF4746 PF15928.5 ETO35597.1 - 0.87 9.0 16.5 1 8.8 16.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Serinc PF03348.15 ETO35597.1 - 1.2 8.0 6.6 1.3 7.8 6.6 1.1 1 0 0 1 1 1 0 Serine incorporator (Serinc) SpoIIP PF07454.11 ETO35597.1 - 1.2 8.5 16.2 1.4 8.3 16.2 1.1 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) CDC45 PF02724.14 ETO35597.1 - 1.3 7.2 15.7 1.6 6.9 15.7 1.2 1 0 0 1 1 1 0 CDC45-like protein Pox_Ag35 PF03286.14 ETO35597.1 - 1.3 8.7 20.3 1.6 8.4 20.3 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein DUF789 PF05623.12 ETO35597.1 - 1.5 8.5 8.9 1.7 8.2 8.9 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF789) DDHD PF02862.17 ETO35597.1 - 1.6 8.8 9.5 2 8.5 9.5 1.1 1 0 0 1 1 1 0 DDHD domain CLN3 PF02487.17 ETO35597.1 - 1.7 7.6 6.6 1.8 7.6 6.6 1.1 1 0 0 1 1 1 0 CLN3 protein MMU163 PF17119.5 ETO35597.1 - 1.8 7.6 7.8 2.1 7.5 7.8 1.1 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis FAM60A PF15396.6 ETO35597.1 - 1.9 8.5 13.4 2.1 8.3 13.4 1.0 1 0 0 1 1 1 0 Protein Family FAM60A DDRGK PF09756.9 ETO35597.1 - 1.9 8.0 26.5 2.4 7.7 26.5 1.1 1 0 0 1 1 1 0 DDRGK domain SLC12 PF03522.15 ETO35597.1 - 2 7.4 13.7 2.2 7.2 13.7 1.1 1 0 0 1 1 1 0 Solute carrier family 12 MCM_bind PF09739.9 ETO35597.1 - 2.1 6.7 13.0 2.3 6.6 13.0 1.0 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor DUF2151 PF10221.9 ETO35597.1 - 2.3 6.7 12.5 2.4 6.7 12.5 1.0 1 0 0 1 1 1 0 Cell cycle and development regulator DUF5427 PF10310.9 ETO35597.1 - 2.7 6.8 18.9 3.1 6.7 18.9 1.0 1 0 0 1 1 1 0 Family of unknown function (DUF5427) CRT10 PF08728.10 ETO35597.1 - 3.1 5.9 8.6 3.2 5.8 8.6 1.0 1 0 0 1 1 1 0 CRT10 CobT PF06213.12 ETO35597.1 - 3.3 7.0 18.5 3.7 6.9 18.5 1.1 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Hid1 PF12722.7 ETO35597.1 - 3.3 5.7 11.8 3.7 5.5 11.8 1.0 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein NOA36 PF06524.12 ETO35597.1 - 3.3 7.0 16.4 3.6 6.8 16.4 1.0 1 0 0 1 1 1 0 NOA36 protein Gti1_Pac2 PF09729.9 ETO35597.1 - 3.5 7.7 12.5 4.1 7.4 12.5 1.1 1 0 0 1 1 1 0 Gti1/Pac2 family DUF4820 PF16091.5 ETO35597.1 - 3.7 6.9 11.3 5.2 6.4 11.3 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Neur_chan_memb PF02932.16 ETO35597.1 - 3.7 7.5 7.5 4.1 7.4 7.5 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region RPN2_C PF18004.1 ETO35597.1 - 3.7 7.4 23.5 5.4 6.9 23.5 1.3 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain AAA_11 PF13086.6 ETO35597.1 - 3.9 7.2 13.2 4.4 7.0 13.2 1.1 1 0 0 1 1 1 0 AAA domain Cellulose_synt PF03552.14 ETO35597.1 - 5.2 5.4 8.7 5.6 5.3 8.7 1.0 1 0 0 1 1 1 0 Cellulose synthase SID-1_RNA_chan PF13965.6 ETO35597.1 - 5.2 5.3 7.9 5.8 5.2 7.9 1.0 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 PA26 PF04636.13 ETO35597.1 - 5.5 5.8 11.5 6 5.7 11.5 1.0 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) DUF4407 PF14362.6 ETO35597.1 - 6 6.1 10.5 6.9 5.9 10.5 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) DNA_pol_phi PF04931.13 ETO35597.1 - 6.1 4.8 19.2 7.6 4.5 19.2 1.0 1 0 0 1 1 1 0 DNA polymerase phi CSG2 PF16965.5 ETO35597.1 - 7.1 5.5 5.3 7.9 5.3 5.3 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator PAF PF15715.5 ETO35597.1 - 7.2 7.2 21.3 8.6 7.0 21.3 1.1 1 0 0 1 1 1 0 PCNA-associated factor histone like domain Paramyxo_ncap PF00973.19 ETO35597.1 - 7.5 5.3 9.3 8.3 5.2 9.3 1.0 1 0 0 1 1 1 0 Paramyxovirus nucleocapsid protein SAPS PF04499.15 ETO35597.1 - 7.8 5.2 15.4 9.1 4.9 15.4 1.0 1 0 0 1 1 1 0 SIT4 phosphatase-associated protein GCD14 PF08704.10 ETO35597.1 - 8.7 5.9 7.7 10 5.7 7.7 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit PBP_sp32 PF07222.12 ETO35597.1 - 8.9 5.7 16.4 11 5.4 16.4 1.1 1 0 0 1 1 1 0 Proacrosin binding protein sp32 Sterol-sensing PF12349.8 ETO35598.1 - 2.4e-22 79.4 1.6 4.2e-22 78.6 1.6 1.3 1 0 0 1 1 1 1 Sterol-sensing domain of SREBP cleavage-activation Patched PF02460.18 ETO35598.1 - 8.2e-22 77.1 0.3 1.1e-21 76.6 0.3 1.1 1 0 0 1 1 1 1 Patched family Patched PF02460.18 ETO35599.1 - 6.1e-13 47.8 12.5 8.2e-13 47.3 12.5 1.1 1 0 0 1 1 1 1 Patched family HRM PF02793.22 ETO35599.1 - 0.022 15.1 1.1 0.022 15.1 1.1 4.5 4 2 1 5 5 5 0 Hormone receptor domain CDC45 PF02724.14 ETO35600.1 - 0.00034 19.1 0.1 0.00049 18.5 0.1 1.2 1 0 0 1 1 1 1 CDC45-like protein NPR3 PF03666.13 ETO35600.1 - 0.037 12.8 1.8 0.074 11.8 1.8 1.5 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 RNA_pol_Rpc4 PF05132.14 ETO35600.1 - 0.46 10.9 1.6 1 9.8 1.6 1.5 1 0 0 1 1 1 0 RNA polymerase III RPC4 Nop14 PF04147.12 ETO35600.1 - 0.68 8.1 8.0 1 7.5 8.0 1.1 1 0 0 1 1 1 0 Nop14-like family Kelch_4 PF13418.6 ETO35601.1 - 8e-05 22.6 0.1 0.058 13.4 0.1 2.5 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO35601.1 - 0.0019 17.8 1.0 0.026 14.1 0.6 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO35601.1 - 0.0026 17.7 0.1 2.5 8.2 0.0 2.9 2 0 0 2 2 2 2 Kelch motif N_Asn_amidohyd PF14736.6 ETO35601.1 - 0.053 12.7 0.1 0.19 10.9 0.0 1.9 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase IL3Ra_N PF18611.1 ETO35601.1 - 0.067 13.2 1.1 0.14 12.2 1.1 1.5 1 0 0 1 1 1 0 IL-3 receptor alpha chain N-terminal domain Kelch_6 PF13964.6 ETO35601.1 - 0.13 12.6 0.8 23 5.5 0.0 2.6 1 1 1 2 2 2 0 Kelch motif Cas_Cmr5 PF09701.10 ETO35603.1 - 0.011 16.1 0.4 0.15 12.4 0.0 2.1 1 1 1 2 2 2 0 CRISPR-associated protein (Cas_Cmr5) Glyco_hydro_8 PF01270.17 ETO35603.1 - 0.072 11.9 0.0 0.094 11.5 0.0 1.1 1 0 0 1 1 1 0 Glycosyl hydrolases family 8 CAT PF00302.18 ETO35603.1 - 0.11 12.4 4.9 0.65 9.9 2.1 2.1 2 0 0 2 2 2 0 Chloramphenicol acetyltransferase TANGO2 PF05742.12 ETO35604.1 - 0.012 15.7 0.9 0.012 15.7 0.9 1.1 1 0 0 1 1 1 0 Transport and Golgi organisation 2 S_100 PF01023.19 ETO35604.1 - 0.097 12.4 3.3 0.19 11.5 3.3 1.4 1 0 0 1 1 1 0 S-100/ICaBP type calcium binding domain GTP_EFTU PF00009.27 ETO35605.1 - 8.8e-20 71.1 0.1 1.7e-13 50.6 0.0 2.0 1 1 1 2 2 2 2 Elongation factor Tu GTP binding domain MMR_HSR1 PF01926.23 ETO35605.1 - 0.049 13.7 0.1 0.29 11.2 0.1 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase CENP-B_dimeris PF09026.10 ETO35606.1 - 0.00017 21.9 3.3 0.00021 21.6 3.3 1.2 1 0 0 1 1 1 1 Centromere protein B dimerisation domain DNA_pol_phi PF04931.13 ETO35606.1 - 0.0059 14.8 1.4 0.0073 14.5 1.4 1.1 1 0 0 1 1 1 1 DNA polymerase phi PBP1_TM PF14812.6 ETO35606.1 - 0.0069 16.7 3.7 0.0093 16.3 3.7 1.4 1 0 0 1 1 1 1 Transmembrane domain of transglycosylase PBP1 at N-terminal NOA36 PF06524.12 ETO35606.1 - 0.052 12.9 6.6 0.056 12.8 6.6 1.1 1 0 0 1 1 1 0 NOA36 protein FAM176 PF14851.6 ETO35606.1 - 0.088 12.5 0.3 0.11 12.1 0.3 1.2 1 0 0 1 1 1 0 FAM176 family RXT2_N PF08595.11 ETO35606.1 - 0.1 12.7 1.6 0.11 12.5 1.6 1.2 1 0 0 1 1 1 0 RXT2-like, N-terminal Cwf_Cwc_15 PF04889.12 ETO35606.1 - 0.14 11.9 7.3 0.15 11.8 7.3 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF2457 PF10446.9 ETO35606.1 - 0.44 9.6 9.4 0.52 9.4 9.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) MitMem_reg PF13012.6 ETO35607.1 - 3.2e-13 50.1 0.1 5.6e-13 49.3 0.1 1.4 1 0 0 1 1 1 1 Maintenance of mitochondrial structure and function JAB PF01398.21 ETO35607.1 - 3.2e-11 43.2 0.0 9.2e-11 41.8 0.0 1.8 1 1 0 1 1 1 1 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PUB PF09409.10 ETO35608.1 - 0.005 16.8 0.6 0.019 14.9 0.6 2.0 1 1 0 1 1 1 1 PUB domain AAA_24 PF13479.6 ETO35608.1 - 0.056 13.2 0.1 0.092 12.5 0.1 1.4 1 0 0 1 1 1 0 AAA domain EF1G PF00647.19 ETO35608.1 - 0.4 10.7 4.4 0.3 11.1 1.7 2.1 1 1 1 2 2 2 0 Elongation factor 1 gamma, conserved domain CW_binding_1 PF01473.20 ETO35608.1 - 0.64 10.5 6.5 0.18 12.2 3.0 2.0 2 0 0 2 2 2 0 Putative cell wall binding repeat Ras PF00071.22 ETO35609.1 - 1.2e-43 148.6 6.3 2e-31 108.8 1.6 2.6 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ETO35609.1 - 2.6e-20 72.8 6.4 5.2e-11 42.8 2.8 2.8 2 1 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO35609.1 - 1.3e-06 28.0 1.4 0.00019 21.0 0.4 2.4 2 1 0 2 2 2 2 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO35609.1 - 0.0011 19.1 0.8 0.011 15.8 0.8 2.2 1 1 0 1 1 1 1 50S ribosome-binding GTPase Vma12 PF11712.8 ETO35610.1 - 0.022 14.8 2.8 0.031 14.3 2.8 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum-based factor for assembly of V-ATPase RNA_pol_Rpc82 PF05645.13 ETO35610.1 - 0.033 13.9 8.0 0.041 13.6 8.0 1.1 1 0 0 1 1 1 0 RNA polymerase III subunit RPC82 DUF1691 PF07950.11 ETO35610.1 - 0.22 12.3 0.7 2.2 9.0 0.7 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1691) CLP_protease PF00574.23 ETO35610.1 - 0.61 9.9 3.5 0.95 9.3 3.5 1.3 1 0 0 1 1 1 0 Clp protease Renin_r PF07850.14 ETO35610.1 - 0.64 10.7 3.4 0.76 10.4 2.6 1.6 1 1 0 1 1 1 0 Renin receptor-like protein Presenilin PF01080.17 ETO35610.1 - 3.5 6.3 5.2 3.8 6.2 5.2 1.2 1 0 0 1 1 1 0 Presenilin G-alpha PF00503.20 ETO35612.1 - 2.6e-32 112.3 5.6 2.9e-32 112.2 5.6 1.0 1 0 0 1 1 1 1 G-protein alpha subunit PI3K_P85_iSH2 PF16454.5 ETO35612.1 - 0.0058 16.2 0.9 0.0071 16.0 0.9 1.1 1 0 0 1 1 1 1 Phosphatidylinositol 3-kinase regulatory subunit P85 inter-SH2 domain Arf PF00025.21 ETO35612.1 - 0.036 13.5 0.2 0.083 12.3 0.2 1.6 1 1 0 1 1 1 0 ADP-ribosylation factor family NACHT PF05729.12 ETO35613.1 - 6.4e-09 35.9 0.0 1.3e-08 35.0 0.0 1.5 1 0 0 1 1 1 1 NACHT domain AAA_22 PF13401.6 ETO35613.1 - 0.00036 20.8 0.3 0.0015 18.8 0.1 2.1 2 1 0 2 2 2 1 AAA domain AAA_18 PF13238.6 ETO35613.1 - 0.0011 19.5 0.1 0.0049 17.4 0.0 2.1 1 1 1 2 2 2 1 AAA domain PRK PF00485.18 ETO35613.1 - 0.0082 15.9 0.0 0.014 15.2 0.0 1.4 1 0 0 1 1 1 1 Phosphoribulokinase / Uridine kinase family RNA_helicase PF00910.22 ETO35613.1 - 0.015 15.7 0.7 0.094 13.1 0.1 2.5 2 1 1 3 3 3 0 RNA helicase TsaE PF02367.17 ETO35613.1 - 0.033 14.2 0.0 0.15 12.1 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_16 PF13191.6 ETO35613.1 - 0.052 13.9 0.1 0.52 10.7 0.0 2.4 1 1 1 2 2 2 0 AAA ATPase domain AAA PF00004.29 ETO35613.1 - 0.056 13.9 0.0 0.12 12.9 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) ATPase PF06745.13 ETO35613.1 - 0.12 11.7 0.1 0.34 10.2 0.1 1.8 1 1 0 1 1 1 0 KaiC ABC_tran PF00005.27 ETO35613.1 - 0.17 12.4 0.3 0.43 11.1 0.1 1.9 2 1 0 2 2 2 0 ABC transporter WD40 PF00400.32 ETO35615.1 - 1.8e-100 326.0 36.1 4.5e-09 36.8 0.0 15.5 14 1 1 15 15 15 13 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35615.1 - 3.3e-25 88.2 12.0 0.0028 17.9 0.0 11.7 3 1 10 13 13 13 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35615.1 - 3.5e-18 65.7 6.3 0.3 10.0 0.0 10.6 1 1 8 11 11 11 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35615.1 - 5e-12 45.7 18.9 0.0011 18.3 0.5 7.0 1 1 4 7 7 7 4 WD40-like domain Nbas_N PF15492.6 ETO35615.1 - 1.3e-07 31.2 12.0 0.14 11.4 0.2 6.5 3 2 3 6 6 6 4 Neuroblastoma-amplified sequence, N terminal Pentapeptide PF00805.22 ETO35615.1 - 9.3e-07 28.4 1.6 2.1e-06 27.3 1.6 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Pentapeptide_4 PF13599.6 ETO35615.1 - 7.6e-05 22.8 0.4 0.00021 21.4 0.4 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF5570 PF17731.1 ETO35615.1 - 0.0024 17.9 4.3 7.9 6.6 0.1 5.9 4 2 3 7 7 7 1 Family of unknown function (DUF5570) POLO_box PF00659.18 ETO35615.1 - 0.0046 17.1 8.7 10 6.4 0.0 7.2 7 2 1 8 8 7 1 POLO box duplicated region Pentapeptide_3 PF13576.6 ETO35615.1 - 0.0058 16.8 0.4 0.0058 16.8 0.4 2.1 2 0 0 2 2 2 1 Pentapeptide repeats (9 copies) Cytochrom_D1 PF02239.16 ETO35615.1 - 0.014 14.0 4.1 1.1 7.7 0.0 3.9 4 1 2 6 6 6 0 Cytochrome D1 heme domain DUF5071 PF16804.5 ETO35616.1 - 0.15 12.3 0.2 0.3 11.3 0.1 1.4 2 0 0 2 2 2 0 Domain of unknown function (DUF5071) C2 PF00168.30 ETO35618.1 - 5.8e-14 52.2 2.9 9.1e-09 35.6 0.1 3.6 3 1 1 4 4 4 2 C2 domain FerI PF08151.12 ETO35618.1 - 3.7e-05 23.7 0.0 7.8e-05 22.7 0.0 1.5 1 0 0 1 1 1 1 FerI (NUC094) domain Ycf1 PF05758.12 ETO35619.1 - 0.097 10.5 2.8 0.098 10.5 2.8 1.0 1 0 0 1 1 1 0 Ycf1 Connexin PF00029.19 ETO35619.1 - 0.2 11.4 2.8 0.2 11.4 2.8 1.1 1 0 0 1 1 1 0 Connexin TFIIE-A_C PF11521.8 ETO35619.1 - 0.42 11.0 6.8 0.55 10.6 6.8 1.3 1 1 0 1 1 1 0 C-terminal general transcription factor TFIIE alpha Presenilin PF01080.17 ETO35619.1 - 0.96 8.1 2.5 0.89 8.2 2.5 1.0 1 0 0 1 1 1 0 Presenilin DUF3464 PF11947.8 ETO35619.1 - 5.3 6.8 5.8 6.5 6.5 5.8 1.1 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 IU_nuc_hydro PF01156.19 ETO35620.1 - 4.1e-13 49.6 0.0 4.7e-13 49.4 0.0 1.1 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase IU_nuc_hydro PF01156.19 ETO35621.1 - 9.6e-22 77.9 0.0 1.1e-21 77.7 0.0 1.0 1 0 0 1 1 1 1 Inosine-uridine preferring nucleoside hydrolase Adap_comp_sub PF00928.21 ETO35622.1 - 1.4e-10 41.0 0.1 3.6e-09 36.4 0.0 2.0 1 1 1 2 2 2 2 Adaptor complexes medium subunit family Clat_adaptor_s PF01217.20 ETO35623.1 - 0.11 12.4 0.8 0.2 11.6 0.8 1.5 1 1 0 1 1 1 0 Clathrin adaptor complex small chain SpoIIIAH PF12685.7 ETO35623.1 - 7.6 6.3 12.8 0.44 10.3 5.6 2.2 3 0 0 3 3 3 0 SpoIIIAH-like protein GNT-I PF03071.15 ETO35624.1 - 9.5e-06 24.6 0.1 1.2e-05 24.3 0.1 1.1 1 0 0 1 1 1 1 GNT-I family Glycos_transf_2 PF00535.26 ETO35624.1 - 0.005 16.7 0.1 0.0082 16.0 0.1 1.4 1 0 0 1 1 1 1 Glycosyl transferase family 2 Glyco_tranf_2_3 PF13641.6 ETO35624.1 - 0.12 12.2 0.0 0.16 11.8 0.0 1.2 1 0 0 1 1 1 0 Glycosyltransferase like family 2 FA_desaturase PF00487.24 ETO35624.1 - 0.17 11.7 0.0 0.33 10.8 0.0 1.4 1 0 0 1 1 1 0 Fatty acid desaturase GNT-I PF03071.15 ETO35625.1 - 2.7e-23 82.4 0.6 3.9e-23 81.9 0.6 1.1 1 0 0 1 1 1 1 GNT-I family Glyco_transf_18 PF15024.6 ETO35625.1 - 0.0028 16.3 5.7 0.0038 15.9 5.7 1.2 1 0 0 1 1 1 1 Glycosyltransferase family 18 WD40 PF00400.32 ETO35626.1 - 1.1e-16 60.9 11.8 2.6e-05 24.9 0.9 4.4 4 3 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35626.1 - 0.011 14.4 0.4 0.26 9.9 0.2 2.5 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Kelch_1 PF01344.25 ETO35627.1 - 9e-05 22.0 0.1 0.00039 19.9 0.1 2.0 2 0 0 2 2 2 1 Kelch motif WASH_WAHD PF11945.8 ETO35627.1 - 0.054 13.0 0.0 0.054 13.0 0.0 1.1 1 0 0 1 1 1 0 WAHD domain of WASH complex Kelch_3 PF13415.6 ETO35627.1 - 0.087 13.1 0.1 0.2 12.0 0.1 1.6 1 0 0 1 1 1 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35627.1 - 0.38 10.8 3.3 0.34 11.0 1.3 2.0 2 1 0 2 2 2 0 Kelch motif Ribosomal_L9_C PF03948.14 ETO35628.1 - 0.13 12.8 0.1 23 5.5 0.0 3.1 3 0 0 3 3 3 0 Ribosomal protein L9, C-terminal domain HemX PF04375.14 ETO35629.1 - 0.017 14.5 0.4 0.021 14.1 0.4 1.2 1 0 0 1 1 1 0 HemX, putative uroporphyrinogen-III C-methyltransferase DapB_N PF01113.20 ETO35629.1 - 0.076 13.1 0.0 0.44 10.7 0.0 2.1 2 0 0 2 2 2 0 Dihydrodipicolinate reductase, N-terminus Heme_oxygenase PF01126.20 ETO35632.1 - 0.04 13.7 0.1 0.098 12.4 0.1 1.6 1 0 0 1 1 1 0 Heme oxygenase AAA PF00004.29 ETO35633.1 - 4.3e-09 36.9 0.0 0.00037 20.9 0.0 3.2 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO35633.1 - 2.2e-08 33.8 0.0 0.00022 20.8 0.0 2.7 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO35633.1 - 1.1e-06 28.7 0.0 0.0084 16.1 0.0 4.5 4 1 0 4 4 4 1 AAA domain (dynein-related subfamily) ABC_tran PF00005.27 ETO35633.1 - 1.5e-06 28.7 0.0 1.3e-05 25.7 0.0 2.5 2 0 0 2 2 2 1 ABC transporter AAA_22 PF13401.6 ETO35633.1 - 5.7e-06 26.6 0.0 0.16 12.3 0.0 3.3 2 0 0 2 2 2 2 AAA domain AAA_8 PF12780.7 ETO35633.1 - 7.2e-05 22.2 0.0 0.00059 19.2 0.0 2.4 2 0 0 2 2 2 1 P-loop containing dynein motor region D4 AAA_16 PF13191.6 ETO35633.1 - 0.00014 22.3 0.0 0.023 15.1 0.0 3.1 2 0 0 2 2 2 1 AAA ATPase domain RsgA_GTPase PF03193.16 ETO35633.1 - 0.00044 20.2 0.0 0.0057 16.6 0.0 2.7 3 0 0 3 3 3 1 RsgA GTPase AAA_21 PF13304.6 ETO35633.1 - 0.0008 19.3 0.0 0.3 10.8 0.0 2.6 2 0 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system MCM PF00493.23 ETO35633.1 - 0.0046 16.1 0.1 0.76 8.8 0.0 2.7 3 0 0 3 3 3 1 MCM P-loop domain Sigma54_activ_2 PF14532.6 ETO35633.1 - 0.0096 16.0 0.0 0.83 9.8 0.0 2.6 2 0 0 2 2 2 1 Sigma-54 interaction domain Sigma54_activat PF00158.26 ETO35633.1 - 0.028 14.1 0.0 0.86 9.3 0.0 2.6 2 0 0 2 2 2 0 Sigma-54 interaction domain TsaE PF02367.17 ETO35633.1 - 0.053 13.5 0.0 0.26 11.3 0.0 2.0 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE PduV-EutP PF10662.9 ETO35633.1 - 0.071 12.9 0.3 0.29 10.9 0.1 2.2 3 0 0 3 3 3 0 Ethanolamine utilisation - propanediol utilisation AAA_19 PF13245.6 ETO35633.1 - 0.12 12.7 2.2 11 6.3 0.2 3.8 2 2 0 2 2 2 0 AAA domain AAA_23 PF13476.6 ETO35633.1 - 0.17 12.4 0.0 0.17 12.4 0.0 3.3 4 0 0 4 4 3 0 AAA domain Mg_chelatase PF01078.21 ETO35633.1 - 0.2 11.0 0.1 13 5.0 0.0 3.2 3 0 0 3 3 3 0 Magnesium chelatase, subunit ChlI Nop14 PF04147.12 ETO35634.1 - 0.57 8.3 12.4 0.71 8.0 12.4 1.1 1 0 0 1 1 1 0 Nop14-like family ISG65-75 PF11727.8 ETO35634.1 - 2.8 7.1 10.7 4.6 6.4 10.7 1.2 1 0 0 1 1 1 0 Invariant surface glycoprotein DUF5082 PF16888.5 ETO35635.1 - 0.00012 22.3 15.2 0.00012 22.3 15.2 2.4 1 1 1 2 2 2 1 Domain of unknown function (DUF5082) SAB PF04382.13 ETO35635.1 - 0.031 14.4 1.5 0.097 12.8 1.5 1.9 1 0 0 1 1 1 0 SAB domain bZIP_1 PF00170.21 ETO35635.1 - 1.3 9.2 28.3 0.23 11.6 4.7 4.5 4 1 0 4 4 4 0 bZIP transcription factor TMPIT PF07851.13 ETO35635.1 - 1.4 8.1 21.9 2.7 7.1 1.3 2.3 2 0 0 2 2 2 0 TMPIT-like protein DUF641 PF04859.12 ETO35635.1 - 2 8.8 16.3 0.25 11.7 10.4 2.3 1 1 0 2 2 2 0 Plant protein of unknown function (DUF641) Jnk-SapK_ap_N PF09744.9 ETO35635.1 - 2.1 8.6 25.1 1.9 8.7 18.9 2.3 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 PACT_coil_coil PF10495.9 ETO35635.1 - 2.1 9.0 5.6 1.5 9.5 0.3 3.0 2 1 2 4 4 4 0 Pericentrin-AKAP-450 domain of centrosomal targeting protein Spc7 PF08317.11 ETO35635.1 - 3.3 6.5 31.7 3 6.6 1.9 2.3 1 1 1 2 2 2 0 Spc7 kinetochore protein DUF2802 PF10975.8 ETO35635.1 - 5.1 7.3 10.3 12 6.1 0.2 3.3 3 1 0 3 3 3 0 Protein of unknown function (DUF2802) Cut12 PF11500.8 ETO35635.1 - 5.5 6.9 17.3 0.064 13.2 7.4 2.8 2 1 1 3 3 3 0 Spindle pole body formation-associated protein APG6_N PF17675.1 ETO35635.1 - 7.4 7.1 25.6 1.6e+02 2.8 0.7 3.2 1 1 1 2 2 2 0 Apg6 coiled-coil region DUF2206 PF09971.9 ETO35636.1 - 0.095 11.4 0.5 0.11 11.2 0.5 1.1 1 0 0 1 1 1 0 Predicted membrane protein (DUF2206) Cytochrom_C1 PF02167.15 ETO35637.1 - 3.4e-28 98.9 0.0 4.5e-28 98.5 0.0 1.1 1 0 0 1 1 1 1 Cytochrome C1 family Cytochrome_CBB3 PF13442.6 ETO35637.1 - 0.00032 21.0 0.1 0.00048 20.4 0.1 1.5 1 1 0 1 1 1 1 Cytochrome C oxidase, cbb3-type, subunit III Cytochrom_C PF00034.21 ETO35637.1 - 0.02 16.0 0.3 0.04 15.1 0.1 1.5 1 1 0 1 1 1 0 Cytochrome c MyTH4 PF00784.17 ETO35637.1 - 0.044 14.3 0.0 0.068 13.7 0.0 1.2 1 0 0 1 1 1 0 MyTH4 domain DivIC PF04977.15 ETO35639.1 - 0.0087 15.8 2.7 0.0087 15.8 2.7 2.4 2 1 1 3 3 3 1 Septum formation initiator WD40 PF00400.32 ETO35640.1 - 4.4e-19 68.5 4.5 3.9e-08 33.8 0.1 5.2 6 0 0 6 6 6 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35640.1 - 1.1e-07 32.0 0.2 0.019 15.3 0.1 3.3 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_2 PF07646.15 ETO35640.1 - 7.7e-06 25.7 3.6 0.058 13.4 0.1 4.8 5 0 0 5 5 5 1 Kelch motif Ge1_WD40 PF16529.5 ETO35640.1 - 0.0005 19.1 0.1 0.013 14.5 0.0 2.3 1 1 1 2 2 2 1 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_5 PF13854.6 ETO35640.1 - 0.0012 18.8 0.0 12 6.0 0.0 4.6 4 0 0 4 4 4 1 Kelch motif Kelch_1 PF01344.25 ETO35640.1 - 0.0029 17.1 1.3 2.3 7.8 0.1 4.3 4 0 0 4 4 4 1 Kelch motif Cytochrom_D1 PF02239.16 ETO35640.1 - 0.011 14.3 0.1 0.02 13.4 0.1 1.5 1 0 0 1 1 1 0 Cytochrome D1 heme domain DUF2272 PF10030.9 ETO35640.1 - 0.024 14.4 0.2 1.5 8.5 0.0 2.8 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_3 PF13415.6 ETO35640.1 - 0.069 13.5 0.2 7.5 7.0 0.0 3.8 4 0 0 4 4 4 0 Galactose oxidase, central domain DUF1797 PF08796.10 ETO35640.1 - 0.11 12.5 0.3 1.3 9.1 0.0 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1797) Kelch_4 PF13418.6 ETO35640.1 - 0.54 10.3 7.8 15 5.7 0.1 4.3 5 0 0 5 5 4 0 Galactose oxidase, central domain DUF2605 PF10792.9 ETO35642.1 - 0.0038 17.1 2.3 2.3 8.2 0.2 3.2 2 0 0 2 2 2 2 Protein of unknown function (DUF2605) CENP-B_dimeris PF09026.10 ETO35642.1 - 4.4 7.8 8.5 13 6.2 8.5 1.7 1 0 0 1 1 1 0 Centromere protein B dimerisation domain BLOC1_2 PF10046.9 ETO35643.1 - 2.1e-23 82.4 4.8 2.1e-23 82.4 4.8 2.1 1 1 1 2 2 2 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 Connexin PF00029.19 ETO35643.1 - 0.05 13.4 0.9 0.065 13.0 0.9 1.1 1 0 0 1 1 1 0 Connexin Presenilin PF01080.17 ETO35643.1 - 0.26 10.0 3.4 0.28 9.9 3.4 1.2 1 0 0 1 1 1 0 Presenilin CLZ PF16526.5 ETO35643.1 - 1.2 9.5 6.7 4.6 7.7 1.8 2.7 1 1 2 3 3 3 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels Adaptin_binding PF10199.9 ETO35643.1 - 1.4 9.5 9.1 13 6.4 9.1 2.1 1 1 0 1 1 1 0 Alpha and gamma adaptin binding protein p34 DUF952 PF06108.12 ETO35644.1 - 0.041 13.9 0.0 0.2 11.7 0.0 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF952) F-box PF00646.33 ETO35644.1 - 0.094 12.6 0.0 0.31 11.0 0.0 1.9 1 0 0 1 1 1 0 F-box domain DUF4611 PF15387.6 ETO35644.1 - 0.41 10.9 4.7 1.1 9.5 4.7 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF4611) Orf78 PF06024.12 ETO35644.1 - 5.5 7.4 6.9 18 5.7 6.9 1.9 1 0 0 1 1 1 0 Orf78 (ac78) TFB6 PF17110.5 ETO35644.1 - 7.1 6.3 6.4 18 5.1 6.4 1.6 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH Helicase_C PF00271.31 ETO35645.1 - 1.5e-25 89.7 1.8 3.2e-25 88.6 0.0 2.5 4 0 0 4 4 4 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO35645.1 - 7.8e-19 68.1 0.0 1.5e-14 54.2 0.0 2.6 2 0 0 2 2 2 2 DEAD/DEAH box helicase ResIII PF04851.15 ETO35645.1 - 0.00061 19.8 0.1 0.0018 18.3 0.1 1.9 1 0 0 1 1 1 1 Type III restriction enzyme, res subunit Helicase_C_2 PF13307.6 ETO35645.1 - 0.0027 17.9 0.5 0.0077 16.4 0.0 2.0 2 0 0 2 2 2 1 Helicase C-terminal domain Peptidase_S49_N PF08496.10 ETO35645.1 - 0.15 12.1 0.3 0.33 11.0 0.3 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal PfkB PF00294.24 ETO35646.1 - 1.5e-36 126.2 0.0 2e-36 125.9 0.0 1.0 1 0 0 1 1 1 1 pfkB family carbohydrate kinase Phos_pyr_kin PF08543.12 ETO35646.1 - 4.5e-05 23.0 0.0 0.00012 21.6 0.0 1.6 2 0 0 2 2 2 1 Phosphomethylpyrimidine kinase Peptidase_C1_2 PF03051.15 ETO35647.1 - 7.2e-104 348.0 2.0 6.3e-79 265.8 0.2 2.0 2 0 0 2 2 2 2 Peptidase C1-like family DUF3450 PF11932.8 ETO35649.1 - 0.16 11.2 9.3 0.3 10.3 9.3 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3450) DUF4094 PF13334.6 ETO35649.1 - 1.1 9.8 8.9 1.1 9.7 5.8 2.7 1 1 1 2 2 2 0 Domain of unknown function (DUF4094) DUF2570 PF10828.8 ETO35649.1 - 1.1 9.1 16.4 0.64 9.9 13.4 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2570) Prefoldin PF02996.17 ETO35649.1 - 2 8.4 12.9 0.092 12.7 3.5 2.9 3 0 0 3 3 3 0 Prefoldin subunit Kelch_6 PF13964.6 ETO35650.1 - 9.1e-06 25.8 1.3 1.1 9.7 0.0 4.0 2 1 1 3 3 3 3 Kelch motif Kelch_5 PF13854.6 ETO35650.1 - 9.7e-05 22.3 6.9 0.12 12.4 1.2 4.5 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO35650.1 - 0.011 15.3 4.8 0.037 13.6 0.5 3.3 3 1 1 4 4 4 0 Kelch motif RL10P_insert PF17777.1 ETO35651.1 - 0.027 14.5 0.1 2.8 8.0 0.0 2.1 1 1 0 2 2 2 0 Insertion domain in 60S ribosomal protein L10P WD40 PF00400.32 ETO35652.1 - 5.8e-11 42.8 6.1 4.2e-08 33.7 0.8 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35652.1 - 0.0012 17.6 0.1 0.0015 17.2 0.1 1.2 1 0 0 1 1 1 1 Nucleoporin Nup120/160 NhaB PF06450.12 ETO35652.1 - 0.0034 16.3 6.0 0.0039 16.1 6.0 1.1 1 0 0 1 1 1 1 Bacterial Na+/H+ antiporter B (NhaB) ANAPC4_WD40 PF12894.7 ETO35652.1 - 0.03 14.6 0.0 0.057 13.7 0.0 1.4 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain DUF3169 PF11368.8 ETO35653.1 - 0.033 13.7 0.4 0.033 13.7 0.4 2.6 1 1 2 3 3 3 0 Protein of unknown function (DUF3169) MG4 PF17789.1 ETO35653.1 - 2.6 8.2 7.9 2.5 8.3 0.7 2.4 1 1 1 2 2 2 0 Macroglobulin domain MG4 Kelch_1 PF01344.25 ETO35654.1 - 5.6e-05 22.6 2.6 0.00013 21.5 0.4 2.5 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO35654.1 - 0.00013 21.9 0.1 0.00079 19.4 0.1 2.2 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO35654.1 - 0.0023 17.8 1.0 0.011 15.7 0.2 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_3 PF13415.6 ETO35654.1 - 0.008 16.4 0.1 0.019 15.3 0.1 1.6 1 0 0 1 1 1 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO35654.1 - 0.046 13.7 1.1 0.43 10.6 0.5 2.3 2 0 0 2 2 2 0 Kelch motif PUB PF09409.10 ETO35655.1 - 0.017 15.0 0.9 0.12 12.3 0.9 2.2 1 1 0 1 1 1 0 PUB domain WD40 PF00400.32 ETO35657.1 - 9.5e-54 178.2 14.9 3.8e-10 40.2 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35657.1 - 8.6e-20 70.8 3.3 0.0016 18.7 0.0 6.5 1 1 6 7 7 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35657.1 - 3e-12 46.1 0.1 0.04 12.9 0.0 5.3 2 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35657.1 - 2.6e-08 33.6 1.5 0.00014 21.3 0.0 3.3 2 1 2 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO35657.1 - 3.2e-06 25.9 0.2 0.0056 15.2 0.1 3.2 2 1 1 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO35657.1 - 3.9e-05 22.5 8.7 0.51 8.9 0.0 5.2 2 2 2 5 5 5 2 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO35657.1 - 0.00044 20.3 0.9 1.9 8.6 0.1 3.8 2 1 2 4 4 4 2 Family of unknown function (DUF5570) Str_synth PF03088.16 ETO35657.1 - 0.0011 19.1 0.3 1.8 8.7 0.0 4.6 2 2 3 5 5 5 1 Strictosidine synthase Nucleoporin_N PF08801.11 ETO35657.1 - 0.0048 15.7 7.8 2 7.1 0.2 4.4 1 1 4 6 6 6 2 Nup133 N terminal like VID27 PF08553.10 ETO35657.1 - 0.019 14.0 0.2 2.7 7.0 0.0 2.2 1 1 1 2 2 2 0 VID27 C-terminal WD40-like domain PD40 PF07676.12 ETO35657.1 - 0.39 10.7 3.7 12 6.0 0.0 3.8 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO35657.1 - 0.54 10.0 1.9 8.2 6.2 0.1 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature SET_assoc PF11767.8 ETO35658.1 - 0.23 11.1 3.3 1.6 8.4 0.3 3.1 3 0 0 3 3 3 0 Histone lysine methyltransferase SET associated Cys_rich_VLP PF14194.6 ETO35659.1 - 0.014 15.5 0.4 0.057 13.5 0.2 1.9 2 0 0 2 2 2 0 Cysteine-rich VLP NapE PF06796.11 ETO35662.1 - 0.075 12.6 0.0 0.19 11.3 0.0 1.7 1 0 0 1 1 1 0 Periplasmic nitrate reductase protein NapE OTOS PF15182.6 ETO35664.1 - 0.0042 17.0 0.2 0.0075 16.2 0.2 1.4 1 1 0 1 1 1 1 Otospiralin BST2 PF16716.5 ETO35665.1 - 5.1e-05 23.8 3.1 5.1e-05 23.8 3.1 9.8 8 3 4 13 13 13 2 Bone marrow stromal antigen 2 SH3_15 PF18346.1 ETO35665.1 - 0.01 16.1 2.6 0.023 15.0 0.1 3.0 3 0 0 3 3 3 0 Mind bomb SH3 repeat domain Glyco_hydro_67C PF07477.12 ETO35665.1 - 0.04 13.5 0.2 0.04 13.5 0.2 3.4 4 0 0 4 4 4 0 Glycosyl hydrolase family 67 C-terminus DUF2959 PF11172.8 ETO35666.1 - 0.014 15.6 2.0 0.025 14.7 2.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2959) Remorin_C PF03763.13 ETO35666.1 - 0.062 13.2 0.2 0.062 13.2 0.2 1.6 2 0 0 2 2 2 0 Remorin, C-terminal region KIF1B PF12423.8 ETO35666.1 - 0.32 11.5 1.4 0.68 10.4 1.4 1.6 1 0 0 1 1 1 0 Kinesin protein 1B NUDIX_2 PF13869.6 ETO35667.1 - 3.7e-67 225.6 0.0 3.7e-67 225.6 0.0 1.8 2 0 0 2 2 2 1 Nucleotide hydrolase DUF4834 PF16118.5 ETO35667.1 - 1.8 9.6 9.6 3.2 8.8 9.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4834) Presenilin PF01080.17 ETO35667.1 - 8.2 5.1 6.8 11 4.7 6.8 1.1 1 0 0 1 1 1 0 Presenilin NIF PF03031.18 ETO35668.1 - 1.9e-14 53.7 0.8 4.1e-14 52.6 0.8 1.5 1 0 0 1 1 1 1 NLI interacting factor-like phosphatase Acid_PPase PF12689.7 ETO35668.1 - 0.017 15.0 0.2 0.017 15.0 0.2 2.2 2 0 0 2 2 2 0 Acid Phosphatase KAR PF15222.6 ETO35668.1 - 0.031 14.5 2.1 0.077 13.3 0.6 2.4 1 1 1 2 2 2 0 Kidney androgen-regulated DUF1682 PF07946.14 ETO35668.1 - 9.5 5.3 19.0 18 4.4 19.0 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) WD40 PF00400.32 ETO35670.1 - 3.8e-05 24.4 11.0 0.033 15.0 0.1 5.6 5 1 0 5 5 5 2 WD domain, G-beta repeat Exo_endo_phos PF03372.23 ETO35671.1 - 5.5e-06 26.1 0.1 1.4e-05 24.7 0.1 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family FrhB_FdhB_C PF04432.13 ETO35671.1 - 0.069 13.0 0.1 0.16 11.8 0.1 1.6 1 0 0 1 1 1 0 Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus EF-hand_6 PF13405.6 ETO35672.1 - 0.0024 17.6 4.1 0.45 10.6 0.3 4.0 4 1 0 4 4 4 1 EF-hand domain EF-hand_7 PF13499.6 ETO35672.1 - 0.0033 17.8 5.8 0.33 11.4 0.5 3.0 2 2 1 3 3 3 3 EF-hand domain pair EF-hand_8 PF13833.6 ETO35672.1 - 0.022 14.6 2.8 0.58 10.1 0.0 2.9 3 0 0 3 3 3 0 EF-hand domain pair AcetDehyd-dimer PF09290.11 ETO35672.1 - 0.086 13.0 0.0 0.12 12.5 0.0 1.3 1 0 0 1 1 1 0 Prokaryotic acetaldehyde dehydrogenase, dimerisation EF-hand_1 PF00036.32 ETO35672.1 - 0.56 9.9 9.8 3.6 7.4 0.1 4.5 6 0 0 6 6 6 0 EF hand Pex24p PF06398.11 ETO35673.1 - 0.043 12.8 0.7 0.052 12.5 0.7 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin GAPT PF11770.8 ETO35674.1 - 0.0046 16.8 3.8 0.0046 16.8 3.8 2.2 2 0 0 2 2 2 1 GRB2-binding adapter (GAPT) Peptidase_S49_N PF08496.10 ETO35674.1 - 7.1 6.7 7.4 0.96 9.5 2.9 1.8 2 0 0 2 2 2 0 Peptidase family S49 N-terminal TFIIB PF00382.19 ETO35677.1 - 8.4e-18 64.2 1.1 1.9e-14 53.5 0.0 3.3 3 0 0 3 3 3 2 Transcription factor TFIIB repeat TF_Zn_Ribbon PF08271.12 ETO35677.1 - 1.2e-05 24.7 8.3 6.3e-05 22.4 8.3 2.4 1 0 0 1 1 1 1 TFIIB zinc-binding BRF1 PF07741.13 ETO35677.1 - 3.6e-05 24.0 0.7 3.6e-05 24.0 0.7 3.3 2 1 1 3 3 3 1 Brf1-like TBP-binding domain Trypan_PARP PF05887.11 ETO35677.1 - 0.0025 17.8 4.2 0.0056 16.7 4.2 1.6 1 0 0 1 1 1 1 Procyclic acidic repetitive protein (PARP) HJURP_mid PF12346.8 ETO35677.1 - 0.057 13.9 1.1 0.24 11.8 1.1 2.1 1 0 0 1 1 1 0 Holliday junction recognition protein-associated repeat CLN3 PF02487.17 ETO35677.1 - 8.8 5.3 5.7 19 4.1 5.7 1.6 1 1 0 1 1 1 0 CLN3 protein CAP_GLY PF01302.25 ETO35678.1 - 5.8e-15 55.1 1.6 1.6e-14 53.7 1.6 1.7 1 0 0 1 1 1 1 CAP-Gly domain Mucin PF01456.17 ETO35678.1 - 0.62 10.0 44.0 0.15 12.0 27.0 3.2 3 0 0 3 3 3 0 Mucin-like glycoprotein FAM176 PF14851.6 ETO35679.1 - 0.47 10.1 7.6 0.26 10.9 1.0 2.5 2 0 0 2 2 2 0 FAM176 family SET PF00856.28 ETO35679.1 - 0.96 9.8 9.3 3.4 8.0 4.6 2.8 2 1 0 2 2 2 0 SET domain DUF5644 PF18712.1 ETO35679.1 - 1.8 8.6 10.2 9.4 6.3 0.2 3.4 3 0 0 3 3 3 0 Family of unknown function (DUF5644) TFB6 PF17110.5 ETO35679.1 - 2.1 8.1 7.9 0.25 11.1 0.5 2.4 2 0 0 2 2 2 0 Subunit 11 of the general transcription factor TFIIH Gti1_Pac2 PF09729.9 ETO35679.1 - 3.3 7.8 11.1 3.2 7.8 2.9 2.4 2 0 0 2 2 2 0 Gti1/Pac2 family CENP-B_dimeris PF09026.10 ETO35679.1 - 5.9 7.3 8.9 0.41 11.1 2.8 2.1 2 0 0 2 2 2 0 Centromere protein B dimerisation domain ARTD15_N PF18084.1 ETO35680.1 - 4.4e-18 65.3 0.1 7.7e-18 64.5 0.1 1.4 1 0 0 1 1 1 1 ARTD15 N-terminal domain PARP PF00644.20 ETO35680.1 - 1.2e-11 44.5 0.5 3.5e-10 39.8 0.2 2.2 2 0 0 2 2 2 1 Poly(ADP-ribose) polymerase catalytic domain PIG-Y PF15159.6 ETO35680.1 - 2.5 9.1 7.6 13 6.7 7.6 2.2 1 1 0 1 1 1 0 Phosphatidylinositol N-acetylglucosaminyltransferase subunit Y WD40 PF00400.32 ETO35681.1 - 1.4e-07 32.0 0.3 4.1e-07 30.6 0.1 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat MOR2-PAG1_C PF14225.6 ETO35682.1 - 1.1e-12 48.3 0.0 3.7e-12 46.6 0.0 1.8 2 0 0 2 2 2 1 Cell morphogenesis C-terminal SNARE PF05739.19 ETO35683.1 - 0.076 13.0 2.5 0.19 11.7 2.5 1.6 1 0 0 1 1 1 0 SNARE domain DUF679 PF05078.12 ETO35683.1 - 0.087 12.8 3.2 0.13 12.2 3.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF679) SpoIISB_antitox PF14185.6 ETO35684.1 - 0.034 14.0 0.8 0.034 14.0 0.8 1.9 2 0 0 2 2 2 0 Antitoxin SpoIISB, type II toxin-antitoxin system YabA PF06156.13 ETO35685.1 - 0.0029 18.2 1.1 0.0032 18.1 1.1 1.2 1 0 0 1 1 1 1 Initiation control protein YabA DUF4047 PF13256.6 ETO35685.1 - 0.039 14.1 0.1 0.041 14.1 0.1 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4047) DivIC PF04977.15 ETO35685.1 - 0.041 13.7 2.1 0.051 13.4 2.1 1.2 1 0 0 1 1 1 0 Septum formation initiator SepSecS PF05889.13 ETO35686.1 - 6.2e-05 21.9 0.3 0.028 13.1 0.1 2.2 1 1 1 2 2 2 2 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Lumazine_bd_2 PF12893.7 ETO35686.1 - 0.09 13.5 0.0 0.14 12.8 0.0 1.2 1 0 0 1 1 1 0 Putative lumazine-binding TPR_6 PF13174.6 ETO35688.1 - 0.061 14.0 0.0 0.37 11.5 0.0 2.4 3 1 0 3 3 3 0 Tetratricopeptide repeat VIR_N PF15912.5 ETO35689.1 - 0.042 13.4 14.7 0.056 13.0 14.7 1.1 1 0 0 1 1 1 0 Virilizer, N-terminal RIFIN PF02009.16 ETO35689.1 - 0.068 13.1 9.8 0.089 12.7 9.8 1.1 1 0 0 1 1 1 0 Rifin RT_RNaseH PF17917.1 ETO35690.1 - 2.1e-07 31.2 0.1 3.1e-05 24.2 0.1 2.5 1 1 0 1 1 1 1 RNase H-like domain found in reverse transcriptase Atx10homo_assoc PF09759.9 ETO35692.1 - 0.0082 16.2 0.7 0.011 15.8 0.0 1.6 2 0 0 2 2 2 1 Spinocerebellar ataxia type 10 protein domain Afi1 PF07792.12 ETO35693.1 - 9.3 6.7 9.6 52 4.3 9.6 2.1 1 1 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking WD40 PF00400.32 ETO35694.1 - 2.3e-10 40.9 4.0 0.5 11.3 0.1 5.8 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35694.1 - 0.014 15.7 0.0 0.1 12.9 0.0 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35694.1 - 0.023 14.0 0.0 0.22 10.8 0.0 2.4 2 1 1 3 3 3 0 WD40-like domain eIF2A PF08662.11 ETO35694.1 - 0.025 14.4 0.0 0.23 11.3 0.0 2.2 2 0 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A SAM_1 PF00536.30 ETO35695.1 - 9.4e-08 32.4 0.1 1.5e-07 31.8 0.1 1.3 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO35695.1 - 1.5e-07 31.4 0.1 2.7e-07 30.6 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_Ste50p PF09235.10 ETO35695.1 - 0.0051 17.0 0.2 0.016 15.5 0.0 1.9 2 0 0 2 2 2 1 Ste50p, sterile alpha motif Peptidase_S10 PF00450.22 ETO35696.1 - 7.1e-28 98.2 0.3 8.8e-28 97.8 0.3 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase DUF1644 PF07800.12 ETO35697.1 - 0.34 11.0 12.1 1.5 8.9 6.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF1644) Cys_knot PF00007.22 ETO35697.1 - 0.91 9.8 10.8 0.28 11.5 6.5 2.1 1 1 0 2 2 2 0 Cystine-knot domain zf_C2H2_6 PF18450.1 ETO35697.1 - 5.7 6.7 9.3 0.64 9.8 4.2 2.1 2 0 0 2 2 2 0 Zinc Finger domain B56 PF01603.20 ETO35698.1 - 3.1e-121 405.2 9.2 3.5e-121 405.1 9.2 1.0 1 0 0 1 1 1 1 Protein phosphatase 2A regulatory B subunit (B56 family) EPL1 PF10513.9 ETO35699.1 - 0.032 14.6 8.2 0.06 13.7 6.9 2.0 2 1 0 2 2 2 0 Enhancer of polycomb-like Mem_trans PF03547.18 ETO35699.1 - 0.083 11.3 0.2 0.1 11.0 0.2 1.4 1 0 0 1 1 1 0 Membrane transport protein OHA PF14418.6 ETO35700.1 - 0.041 13.7 0.1 4.9 7.0 0.0 2.4 2 0 0 2 2 2 0 OST-HTH Associated domain HTH_52 PF18576.1 ETO35700.1 - 0.096 12.9 0.1 0.21 11.8 0.1 1.6 1 0 0 1 1 1 0 Helix-turn-helix domain CHAD PF05235.14 ETO35701.1 - 0.023 14.7 7.3 0.44 10.5 0.8 2.1 2 0 0 2 2 2 0 CHAD domain TMEM237 PF15383.6 ETO35701.1 - 9.8 5.2 9.0 6.9 5.7 0.4 2.8 3 0 0 3 3 3 0 Transmembrane protein 237 Aminotran_1_2 PF00155.21 ETO35702.1 - 4.9e-49 167.4 0.0 5.8e-49 167.2 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_3 PF00202.21 ETO35702.1 - 4.9e-08 32.0 0.0 7.7e-08 31.4 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class-III Aminotran_5 PF00266.19 ETO35702.1 - 0.0047 15.9 0.0 0.0081 15.1 0.0 1.3 1 0 0 1 1 1 1 Aminotransferase class-V SHMT PF00464.19 ETO35702.1 - 0.011 14.4 0.0 0.017 13.7 0.0 1.4 1 0 0 1 1 1 0 Serine hydroxymethyltransferase Beta_elim_lyase PF01212.21 ETO35702.1 - 0.017 14.4 0.1 0.02 14.2 0.1 1.2 1 0 0 1 1 1 0 Beta-eliminating lyase Zot PF05707.12 ETO35702.1 - 0.047 13.3 0.9 0.26 10.9 0.0 2.1 2 0 0 2 2 2 0 Zonular occludens toxin (Zot) SepSecS PF05889.13 ETO35702.1 - 0.15 10.7 0.0 0.23 10.1 0.0 1.2 1 0 0 1 1 1 0 O-phosphoseryl-tRNA(Sec) selenium transferase, SepSecS Met_gamma_lyase PF06838.11 ETO35702.1 - 0.16 10.5 0.0 0.22 10.0 0.0 1.3 1 0 0 1 1 1 0 Methionine gamma-lyase WD40 PF00400.32 ETO35703.1 - 1.6e-51 171.1 25.1 1.8e-09 38.0 0.0 6.6 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35703.1 - 5.7e-16 58.6 2.6 0.015 15.6 0.1 5.4 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35703.1 - 3.7e-14 52.4 0.5 0.0041 16.1 0.0 5.3 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35703.1 - 1.7e-08 34.2 0.5 0.0029 17.0 0.0 3.1 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO35703.1 - 1e-05 24.4 4.9 3.8 6.0 0.2 5.1 1 1 3 5 5 5 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO35703.1 - 0.0072 16.2 0.8 2.4 8.2 0.0 3.7 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO35703.1 - 0.014 15.5 3.3 12 6.0 0.1 3.7 2 1 2 4 4 4 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO35703.1 - 0.047 12.2 0.2 0.62 8.5 0.0 2.4 1 1 1 3 3 3 0 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO35703.1 - 0.048 12.6 0.9 1.7 7.5 0.0 2.9 2 1 0 2 2 2 0 Partner and localizer of BRCA2 WD40 domain Nucleoporin_N PF08801.11 ETO35703.1 - 0.084 11.6 2.8 0.83 8.3 0.1 2.8 1 1 2 3 3 3 0 Nup133 N terminal like WD40 PF00400.32 ETO35704.1 - 4.8e-35 119.0 31.9 4.2e-07 30.6 0.1 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35704.1 - 1.4e-12 47.7 1.6 0.033 14.5 0.0 5.4 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35704.1 - 1.5e-09 37.1 4.6 0.54 8.8 0.0 5.1 2 2 3 5 5 5 5 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO35704.1 - 0.00047 20.2 0.4 3.6 7.7 0.0 3.3 2 1 0 3 3 3 2 Ciliary BBSome complex subunit 2, middle region DUF851 PF05867.11 ETO35704.1 - 0.018 14.5 0.4 4.1 6.8 0.0 3.4 3 1 1 4 4 4 0 Protein of unknown function (DUF851) Destabilase PF05497.12 ETO35705.1 - 9.3e-08 32.4 0.4 1.4e-07 31.9 0.4 1.3 1 0 0 1 1 1 1 Destabilase Blt1_C PF17183.4 ETO35705.1 - 0.043 13.4 0.0 0.068 12.8 0.0 1.4 1 0 0 1 1 1 0 Get5 carboxyl domain DUF5580 PF17743.1 ETO35708.1 - 0.61 8.6 8.3 0.092 11.3 3.7 1.7 1 1 1 2 2 2 0 Family of unknown function (DUF5580) Nop14 PF04147.12 ETO35708.1 - 0.66 8.1 7.8 0.71 8.0 7.8 1.1 1 0 0 1 1 1 0 Nop14-like family FAM176 PF14851.6 ETO35708.1 - 0.86 9.3 9.1 0.15 11.7 3.6 2.0 2 0 0 2 2 2 0 FAM176 family Presenilin PF01080.17 ETO35708.1 - 1.6 7.4 4.7 2 7.1 4.7 1.1 1 0 0 1 1 1 0 Presenilin PPP4R2 PF09184.11 ETO35708.1 - 5.2 6.6 16.8 6.6 6.2 16.8 1.1 1 0 0 1 1 1 0 PPP4R2 RXT2_N PF08595.11 ETO35708.1 - 7.6 6.5 13.0 0.95 9.5 7.5 1.9 2 0 0 2 2 2 0 RXT2-like, N-terminal DNA_pol_phi PF04931.13 ETO35708.1 - 7.6 4.5 9.4 12 3.8 9.4 1.3 1 0 0 1 1 1 0 DNA polymerase phi TAFH PF07531.14 ETO35710.1 - 0.0039 17.3 0.4 0.041 14.0 0.1 2.3 2 0 0 2 2 2 1 NHR1 homology to TAF RGS PF00615.19 ETO35711.1 - 0.00019 21.7 0.2 0.0017 18.6 0.2 2.2 1 1 0 1 1 1 1 Regulator of G protein signaling domain NUP50 PF08911.11 ETO35712.1 - 0.011 16.4 0.2 0.013 16.2 0.2 1.2 1 0 0 1 1 1 0 NUP50 (Nucleoporin 50 kDa) DUF4951 PF16309.5 ETO35712.1 - 0.033 14.2 0.1 0.044 13.8 0.1 1.3 1 0 0 1 1 1 0 Domian of unknown function (DUF4951) BTHB PF18410.1 ETO35712.1 - 0.38 10.6 5.0 1.5 8.7 0.1 2.9 1 1 2 3 3 3 0 Basic tilted helix bundle domain DUF1539 PF07560.11 ETO35714.1 - 0.0097 16.0 0.1 0.0097 16.0 0.1 2.7 3 0 0 3 3 3 1 Domain of Unknown Function (DUF1539) WD40 PF00400.32 ETO35715.1 - 1.1e-29 102.0 2.0 1.9e-09 38.0 0.1 6.2 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35715.1 - 2.7e-11 43.6 1.8 0.11 12.9 0.1 5.0 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35715.1 - 1.2e-07 31.0 0.3 0.0095 14.9 0.0 4.1 1 1 3 4 4 4 2 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO35715.1 - 1.4e-05 25.1 0.8 0.022 14.6 0.0 3.1 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO35715.1 - 2.3e-05 23.9 5.2 0.066 12.5 0.0 3.0 1 1 2 3 3 3 2 WD40-like domain Nucleoporin_N PF08801.11 ETO35715.1 - 8.9e-05 21.4 3.5 0.64 8.7 0.1 3.7 1 1 3 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO35715.1 - 0.00024 19.8 0.1 0.03 12.9 0.1 2.2 1 1 1 2 2 2 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO35715.1 - 0.00024 19.9 4.9 0.45 9.1 0.0 4.2 1 1 2 4 4 4 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO35715.1 - 0.00047 20.2 0.8 0.054 13.5 0.1 2.9 2 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region PD40 PF07676.12 ETO35715.1 - 0.0013 18.6 0.0 7.1 6.7 0.0 4.2 4 0 0 4 4 4 1 WD40-like Beta Propeller Repeat B_lectin PF01453.24 ETO35715.1 - 0.065 13.8 2.4 0.14 12.7 0.1 2.6 1 1 2 3 3 3 0 D-mannose binding lectin MMU163 PF17119.5 ETO35717.1 - 0.071 12.3 2.2 0.15 11.2 2.2 1.5 1 0 0 1 1 1 0 Mitochondrial protein up-regulated during meiosis Striatin PF08232.12 ETO35717.1 - 0.36 11.4 7.1 0.061 13.9 2.2 1.9 2 0 0 2 2 2 0 Striatin family DBC1 PF14443.6 ETO35718.1 - 0.061 13.3 0.8 0.11 12.5 0.8 1.6 1 1 0 1 1 1 0 DBC1 O_Spanin_T7 PF17531.2 ETO35718.1 - 0.16 12.1 0.2 0.28 11.3 0.2 1.4 1 0 0 1 1 1 0 outer-membrane spanin sub-unit Radical_SAM_C PF16199.5 ETO35719.1 - 0.1 12.6 0.0 0.3 11.1 0.0 1.7 2 0 0 2 2 2 0 Radical_SAM C-terminal domain Kelch_1 PF01344.25 ETO35721.1 - 1.1e-05 24.9 2.7 0.0038 16.8 0.2 3.0 3 0 0 3 3 3 2 Kelch motif Kelch_6 PF13964.6 ETO35721.1 - 2.1e-05 24.6 1.3 0.2 12.0 0.2 3.3 2 0 0 2 2 2 2 Kelch motif Kelch_2 PF07646.15 ETO35721.1 - 0.0037 17.2 0.8 0.98 9.5 0.1 2.7 2 0 0 2 2 2 2 Kelch motif MMTV_SAg PF01054.17 ETO35721.1 - 0.21 11.1 0.3 0.5 9.9 0.1 1.6 2 0 0 2 2 2 0 Mouse mammary tumour virus superantigen NACHT PF05729.12 ETO35723.1 - 1.1e-05 25.4 0.0 2.1e-05 24.5 0.0 1.5 2 0 0 2 2 2 1 NACHT domain WD40 PF00400.32 ETO35724.1 - 3.1e-19 68.9 12.9 2.9e-06 27.9 1.2 4.2 4 1 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35724.1 - 2.7e-09 36.2 1.3 0.0012 17.6 0.2 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35724.1 - 1.2e-05 25.5 0.0 0.063 13.6 0.0 2.8 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35724.1 - 0.00035 20.0 5.6 0.0048 16.3 1.2 2.7 1 1 2 3 3 3 2 WD40-like domain WD40 PF00400.32 ETO35725.1 - 3.9e-29 100.3 20.4 9e-07 29.5 0.2 5.9 5 1 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35725.1 - 7.3e-10 39.0 0.3 0.0091 16.3 0.0 4.1 3 2 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35725.1 - 5.2e-06 25.4 4.8 0.12 11.0 1.4 4.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35725.1 - 9.9e-05 21.8 0.4 0.026 13.8 0.0 3.1 2 1 1 3 3 3 1 WD40-like domain BBS2_Mid PF14783.6 ETO35725.1 - 0.003 17.6 0.3 0.47 10.5 0.1 3.4 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region LydB PF16084.5 ETO35725.1 - 0.14 12.0 0.0 0.44 10.4 0.0 1.8 2 0 0 2 2 2 0 LydA-holin antagonist WD40 PF00400.32 ETO35726.1 - 2.3e-18 66.2 6.7 1.2e-05 25.9 0.1 4.3 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35726.1 - 0.00022 20.0 0.7 0.082 11.5 0.5 2.8 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35726.1 - 0.0061 16.8 0.1 7.6 6.9 0.0 3.1 1 1 2 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Marek_SORF3 PF07153.11 ETO35726.1 - 0.012 15.0 0.0 0.016 14.6 0.0 1.1 1 0 0 1 1 1 0 Marek's disease-like virus SORF3 protein Kelch_6 PF13964.6 ETO35726.1 - 0.45 10.9 2.6 2.5 8.5 0.1 3.1 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO35727.1 - 5.4e-14 52.4 15.1 0.00031 21.5 0.0 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat eIF2A PF08662.11 ETO35727.1 - 0.0019 18.1 0.4 0.011 15.6 0.3 2.0 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO35727.1 - 0.003 16.3 0.2 0.14 10.8 0.2 2.6 1 1 0 1 1 1 1 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35727.1 - 0.0042 17.4 0.2 0.14 12.5 0.1 2.6 1 1 1 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain DUF812 PF05667.11 ETO35729.1 - 0.00016 20.7 10.7 0.00016 20.7 10.7 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF812) DIL PF01843.19 ETO35729.1 - 0.052 13.8 0.2 5.5 7.3 0.0 3.1 2 0 0 2 2 2 0 DIL domain UQ_con PF00179.26 ETO35730.1 - 7e-41 139.2 0.1 2.9e-37 127.5 0.0 2.9 1 1 1 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO35730.1 - 0.00026 20.7 0.0 0.00039 20.1 0.0 1.2 1 0 0 1 1 1 1 Prokaryotic E2 family B RWD PF05773.22 ETO35730.1 - 0.069 13.4 0.0 0.099 12.9 0.0 1.3 1 0 0 1 1 1 0 RWD domain Pyr_redox_2 PF07992.14 ETO35731.1 - 4.4e-15 55.7 0.1 3.1e-13 49.6 0.1 2.1 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox PF00070.27 ETO35731.1 - 1.7e-06 28.5 0.0 3.5e-06 27.5 0.0 1.5 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Plug_translocon PF10559.9 ETO35732.1 - 1.6e-09 37.5 0.0 6.9e-09 35.4 0.0 2.1 2 0 0 2 2 2 1 Plug domain of Sec61p Prion_bPrPp PF11587.8 ETO35732.1 - 0.031 14.1 2.9 0.085 12.7 2.9 1.7 1 0 0 1 1 1 0 Major prion protein bPrPp - N terminal SPOB_ab PF14682.6 ETO35733.1 - 0.082 13.0 0.1 0.13 12.3 0.1 1.4 1 0 0 1 1 1 0 Sporulation initiation phospho-transferase B, C-terminal HSDR_N_2 PF13588.6 ETO35734.1 - 0.0027 17.7 3.4 1 9.4 0.2 2.4 2 0 0 2 2 2 2 Type I restriction enzyme R protein N terminus (HSDR_N) WD40 PF00400.32 ETO35735.1 - 3.1e-09 37.3 8.3 8.6e-06 26.4 0.9 3.1 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35735.1 - 0.022 13.4 0.6 0.44 9.1 0.1 2.0 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Gtr1_RagA PF04670.12 ETO35736.1 - 2.4e-41 141.6 4.9 3.5e-41 141.1 2.4 2.2 2 1 0 2 2 2 1 Gtr1/RagA G protein conserved region MMR_HSR1 PF01926.23 ETO35736.1 - 0.0011 19.1 0.0 0.008 16.3 0.0 2.4 2 1 0 2 2 2 1 50S ribosome-binding GTPase SRPRB PF09439.10 ETO35736.1 - 0.017 14.6 0.0 0.043 13.3 0.0 1.7 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit HEAT PF02985.22 ETO35737.1 - 3.1e-08 33.2 0.0 0.01 16.0 0.0 2.5 2 0 0 2 2 2 2 HEAT repeat HEAT_2 PF13646.6 ETO35737.1 - 0.00021 21.6 0.1 0.0023 18.3 0.0 2.2 1 1 1 2 2 2 1 HEAT repeats TAF6_C PF07571.13 ETO35737.1 - 0.095 13.0 0.0 2.5 8.5 0.0 2.4 1 1 0 1 1 1 0 TAF6 C-terminal HEAT repeat domain SMC_N PF02463.19 ETO35738.1 - 1e-13 51.3 1.7 1.7e-13 50.5 1.7 1.3 1 1 0 1 1 1 1 RecF/RecN/SMC N terminal domain SbcCD_C PF13558.6 ETO35738.1 - 0.0012 19.0 0.1 0.0053 17.0 0.0 1.9 2 0 0 2 2 2 1 Putative exonuclease SbcCD, C subunit DUF3211 PF11485.8 ETO35738.1 - 0.016 15.5 0.6 0.04 14.1 0.3 1.9 1 1 1 2 2 2 0 Protein of unknown function (DUF3211) Syntaxin-18_N PF10496.9 ETO35738.1 - 0.034 14.4 2.3 0.066 13.5 2.3 1.6 1 1 0 1 1 1 0 SNARE-complex protein Syntaxin-18 N-terminus ABC_tran PF00005.27 ETO35738.1 - 0.15 12.6 1.4 0.27 11.7 1.4 1.5 1 1 0 1 1 1 0 ABC transporter Adeno_E3 PF06040.11 ETO35740.1 - 1.2 9.3 10.3 0.071 13.3 5.2 1.6 1 1 1 2 2 2 0 Adenovirus E3 protein WD40 PF00400.32 ETO35741.1 - 1e-12 48.3 1.1 0.0009 20.0 0.0 3.5 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35741.1 - 0.00067 19.9 0.1 0.18 12.1 0.0 2.6 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35741.1 - 0.0091 14.7 0.0 1.4 7.4 0.0 2.0 2 0 0 2 2 2 2 Nucleoporin Nup120/160 DUF572 PF04502.13 ETO35744.1 - 1e-54 186.4 27.9 1.6e-54 185.8 27.9 1.4 1 0 0 1 1 1 1 Family of unknown function (DUF572) RNA_pol_N PF01194.17 ETO35744.1 - 0.39 11.0 4.0 3.6 8.0 0.0 3.2 4 0 0 4 4 4 0 RNA polymerases N / 8 kDa subunit RNA_POL_M_15KD PF02150.16 ETO35744.1 - 1.4 8.8 4.7 3.4 7.6 0.6 2.5 2 0 0 2 2 2 0 RNA polymerases M/15 Kd subunit HEAT PF02985.22 ETO35746.1 - 0.00017 21.6 0.2 0.9 10.0 0.0 4.0 4 0 0 4 4 4 1 HEAT repeat HEAT_2 PF13646.6 ETO35746.1 - 0.00025 21.4 0.0 0.037 14.4 0.0 2.6 1 1 1 2 2 2 1 HEAT repeats MMS19_C PF12460.8 ETO35746.1 - 0.00025 20.3 2.3 0.00073 18.8 0.7 2.0 1 1 1 2 2 2 1 RNAPII transcription regulator C-terminal HEAT_EZ PF13513.6 ETO35746.1 - 0.00084 19.8 0.0 0.041 14.4 0.0 3.1 2 1 1 3 3 3 1 HEAT-like repeat Cnd1 PF12717.7 ETO35746.1 - 0.0014 18.7 5.2 0.015 15.4 0.1 2.8 1 1 2 3 3 3 1 non-SMC mitotic condensation complex subunit 1 UPF0147 PF03685.13 ETO35746.1 - 0.026 14.6 0.2 0.069 13.2 0.2 1.7 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0147) MMS19_N PF14500.6 ETO35746.1 - 0.032 13.8 0.1 0.22 11.1 0.1 2.4 1 1 0 1 1 1 0 Dos2-interacting transcription regulator of RNA-Pol-II Vac14_Fab1_bd PF12755.7 ETO35746.1 - 0.037 14.6 1.9 2.9 8.5 0.0 3.3 2 1 1 3 3 3 0 Vacuolar 14 Fab1-binding region CLASP_N PF12348.8 ETO35746.1 - 0.049 13.2 1.8 0.33 10.5 0.9 2.5 2 1 0 2 2 2 0 CLASP N terminal DSHCT PF08148.12 ETO35746.1 - 0.065 12.9 0.1 0.51 10.0 0.0 2.1 2 0 0 2 2 2 0 DSHCT (NUC185) domain IPK PF03770.16 ETO35746.1 - 0.085 12.7 1.4 0.19 11.6 1.0 1.7 1 1 0 1 1 1 0 Inositol polyphosphate kinase DUF2919 PF11143.8 ETO35747.1 - 0.0036 17.7 0.2 0.0036 17.7 0.2 1.8 2 0 0 2 2 2 1 Protein of unknown function (DUF2919) Calpain_III PF01067.22 ETO35748.1 - 1.8e-10 41.2 1.6 5.2e-09 36.5 1.6 2.2 1 1 0 1 1 1 1 Calpain large subunit, domain III DUF4087 PF13316.6 ETO35748.1 - 0.031 14.8 0.2 0.094 13.2 0.1 1.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4087) WD40 PF00400.32 ETO35749.1 - 3.9e-50 166.7 15.8 1.5e-07 32.0 0.1 7.2 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35749.1 - 4.3e-19 68.6 0.9 0.0017 18.6 0.0 6.0 1 1 5 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35749.1 - 6.2e-10 38.6 2.9 0.12 11.3 0.1 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO35749.1 - 6.5e-07 28.4 6.0 0.14 10.8 0.1 4.4 1 1 3 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35749.1 - 8.7e-05 22.0 1.2 2.7 7.2 0.1 3.5 2 2 2 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO35749.1 - 0.00035 20.4 2.8 9.9 6.2 0.1 4.8 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO35749.1 - 0.0055 16.8 2.9 0.94 9.6 0.0 4.2 2 2 2 5 5 5 1 Family of unknown function (DUF5570) DUF3748 PF12566.8 ETO35749.1 - 0.027 14.4 0.2 4.8 7.2 0.0 2.6 2 1 0 2 2 2 0 Protein of unknown function (DUF3748) DUF5449 PF17528.2 ETO35749.1 - 0.075 12.8 0.2 3.7 7.3 0.0 2.7 1 1 2 3 3 3 0 Family of unknown function (DUF5449) DUF1652 PF07865.11 ETO35749.1 - 0.12 12.2 0.0 7.3 6.5 0.0 3.2 2 1 1 3 3 3 0 Protein of unknown function (DUF1652) Phage_terminase PF10668.9 ETO35749.1 - 0.21 11.6 0.8 2.3 8.3 0.0 3.1 4 0 0 4 4 4 0 Phage terminase small subunit Aminotran_1_2 PF00155.21 ETO35750.1 - 3e-54 184.6 0.0 2.2e-41 142.2 0.0 2.1 2 0 0 2 2 2 2 Aminotransferase class I and II Cys_Met_Meta_PP PF01053.20 ETO35750.1 - 1.3e-05 23.9 0.0 2.2e-05 23.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Beta_elim_lyase PF01212.21 ETO35750.1 - 9.7e-05 21.8 0.0 0.00016 21.0 0.0 1.3 1 0 0 1 1 1 1 Beta-eliminating lyase DegT_DnrJ_EryC1 PF01041.17 ETO35750.1 - 0.00014 21.3 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ETO35750.1 - 0.0026 16.8 0.0 0.0069 15.4 0.0 1.6 2 0 0 2 2 2 1 Aminotransferase class-V DUF1499 PF07386.11 ETO35750.1 - 0.13 12.8 0.0 0.79 10.3 0.0 2.2 2 1 0 2 2 2 0 Protein of unknown function (DUF1499) GRIM-19 PF06212.12 ETO35750.1 - 0.17 11.8 0.0 0.32 10.9 0.0 1.4 1 0 0 1 1 1 0 GRIM-19 protein CBS PF00571.28 ETO35750.1 - 0.18 12.3 0.0 5.2 7.6 0.0 2.6 2 0 0 2 2 2 0 CBS domain WD40 PF00400.32 ETO35751.1 - 6.8e-11 42.6 11.8 1.2e-06 29.2 1.7 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35751.1 - 0.0023 16.7 1.3 0.7 8.5 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35751.1 - 0.014 15.7 0.0 0.063 13.6 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO35752.1 - 1.3e-11 44.8 9.3 4.2e-06 27.4 0.3 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35752.1 - 0.00021 21.5 0.1 0.046 14.0 0.0 3.1 2 2 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35752.1 - 0.00059 18.6 0.4 0.8 8.3 0.0 2.9 1 1 1 2 2 2 2 Nucleoporin Nup120/160 STATa_Ig PF18214.1 ETO35753.1 - 1.1 9.3 7.4 1.1 9.3 5.5 2.0 2 0 0 2 2 2 0 STATa Immunoglobulin-like domain CPSF100_C PF13299.6 ETO35753.1 - 2.7 8.1 15.4 1.3 9.2 9.3 2.4 2 0 0 2 2 2 0 Cleavage and polyadenylation factor 2 C-terminal CLN3 PF02487.17 ETO35753.1 - 8.5 5.3 6.6 18 4.3 6.6 1.6 1 0 0 1 1 1 0 CLN3 protein PPR_3 PF13812.6 ETO35754.1 - 2.2e-13 50.1 6.6 0.00022 21.2 0.0 5.5 3 1 2 5 5 5 3 Pentatricopeptide repeat domain PPR_2 PF13041.6 ETO35754.1 - 9.4e-10 38.5 10.8 0.00019 21.6 0.3 5.0 4 1 2 6 6 6 4 PPR repeat family PPR PF01535.20 ETO35754.1 - 1.1e-09 37.9 5.2 0.14 12.5 0.1 5.2 5 0 0 5 5 5 3 PPR repeat WD40 PF00400.32 ETO35754.1 - 7.5e-09 36.1 2.5 9.5e-05 23.1 0.4 3.2 2 0 0 2 2 2 2 WD domain, G-beta repeat PPR_long PF17177.4 ETO35754.1 - 0.00015 21.2 0.0 0.00027 20.4 0.0 1.4 1 0 0 1 1 1 1 Pentacotripeptide-repeat region of PRORP PPR_1 PF12854.7 ETO35754.1 - 0.00015 21.4 8.4 0.36 10.6 0.0 4.5 4 0 0 4 4 4 2 PPR repeat VD10_N PF08476.10 ETO35754.1 - 0.027 14.1 0.4 0.068 12.8 0.4 1.7 1 0 0 1 1 1 0 Viral D10 N-terminal DUF4767 PF15983.5 ETO35754.1 - 0.06 13.6 0.2 0.06 13.6 0.2 2.3 3 0 0 3 3 3 0 Domain of unknown function (DUF4767) WD40 PF00400.32 ETO35755.1 - 1.7e-42 142.6 29.7 2.1e-08 34.7 1.6 6.9 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35755.1 - 9.7e-12 45.0 4.8 0.022 15.0 0.0 6.3 5 2 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35755.1 - 2e-06 26.7 11.5 0.032 12.9 0.2 5.2 1 1 5 6 6 6 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO35755.1 - 0.026 13.3 12.3 0.22 10.2 3.0 3.6 1 1 2 4 4 4 0 Nup133 N terminal like RAP-1 PF03085.15 ETO35756.1 - 0.01 15.5 4.6 0.013 15.2 4.6 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) WD40 PF00400.32 ETO35757.1 - 3e-21 75.3 12.9 1.6e-05 25.6 0.1 5.9 5 1 0 5 5 5 4 WD domain, G-beta repeat Nup160 PF11715.8 ETO35757.1 - 2.3e-05 23.3 4.2 0.38 9.3 0.8 4.0 2 2 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35757.1 - 0.0014 18.9 0.4 32 4.9 0.0 4.2 3 1 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain GTP_EFTU PF00009.27 ETO35757.1 - 0.002 17.7 0.0 0.0035 16.9 0.0 1.5 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain TMEM215 PF15746.5 ETO35758.1 - 0.013 14.9 0.0 0.023 14.2 0.0 1.4 1 0 0 1 1 1 0 TMEM215 family Ribonuc_L-PSP PF01042.21 ETO35759.1 - 2.1e-05 24.5 0.0 5.7e-05 23.1 0.0 1.7 2 0 0 2 2 2 1 Endoribonuclease L-PSP DUF4806 PF16064.5 ETO35759.1 - 0.11 12.8 0.5 0.22 11.9 0.5 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4806) Pox_J1 PF03338.15 ETO35760.1 - 0.013 15.3 0.7 1.1 9.1 0.2 2.5 2 0 0 2 2 2 0 Poxvirus J1 protein Mucin PF01456.17 ETO35760.1 - 0.028 14.4 51.4 0.067 13.2 51.4 1.5 1 0 0 1 1 1 0 Mucin-like glycoprotein ZIP4_domain PF18292.1 ETO35760.1 - 0.043 13.7 2.8 0.073 13.0 0.2 2.1 1 1 1 2 2 2 0 Zinc transporter ZIP4 domain GCOM2 PF15328.6 ETO35760.1 - 0.11 12.8 4.9 0.16 12.3 4.9 1.2 1 0 0 1 1 1 0 Putative GRINL1B complex locus protein 2 NUDE_C PF04880.13 ETO35760.1 - 4.4 7.8 10.1 7.1 7.1 10.1 1.3 1 0 0 1 1 1 0 NUDE protein, C-terminal conserved region WD40 PF00400.32 ETO35761.1 - 2.7e-17 62.8 20.7 8.2e-06 26.5 1.7 4.8 5 0 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35761.1 - 2.1e-06 27.9 0.9 0.24 11.7 0.1 3.6 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35761.1 - 1.5e-05 23.9 1.2 0.01 14.5 0.7 2.2 1 1 0 2 2 2 2 Nucleoporin Nup120/160 ubiquitin PF00240.23 ETO35763.1 - 1.1e-13 50.7 1.6 1.9e-13 49.9 0.1 2.3 2 1 0 2 2 2 1 Ubiquitin family Rad60-SLD PF11976.8 ETO35763.1 - 3.9e-08 33.0 0.8 1.2e-06 28.2 0.0 2.6 3 0 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like DUF3258 PF11646.8 ETO35763.1 - 0.041 14.0 0.2 0.084 13.0 0.2 1.6 1 1 0 1 1 1 0 Protein of unknown function DUF3258 Nuc_sug_transp PF04142.15 ETO35764.1 - 4.1e-26 91.9 1.2 4.5e-26 91.8 1.2 1.2 1 0 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ETO35764.1 - 3e-05 24.2 9.1 3.1e-05 24.1 2.4 2.1 2 0 0 2 2 2 1 EamA-like transporter family UAA PF08449.11 ETO35764.1 - 0.00017 20.9 0.4 0.00017 20.9 0.4 1.7 2 1 0 2 2 2 1 UAA transporter family Spore_YabQ PF09578.10 ETO35764.1 - 0.012 15.8 2.7 0.012 15.8 2.7 2.5 2 1 0 2 2 2 0 Spore cortex protein YabQ (Spore_YabQ) GET2 PF08690.10 ETO35764.1 - 0.03 14.0 0.2 0.039 13.6 0.2 1.2 1 0 0 1 1 1 0 GET complex subunit GET2 Nuc_sug_transp PF04142.15 ETO35765.1 - 2.8e-26 92.4 14.0 4.6e-26 91.7 14.0 1.3 1 0 0 1 1 1 1 Nucleotide-sugar transporter UPF0060 PF02694.15 ETO35765.1 - 0.061 13.6 4.5 0.85 9.9 1.5 2.4 1 1 1 2 2 2 0 Uncharacterised BCR, YnfA/UPF0060 family CENP-F_C_Rb_bdg PF10490.9 ETO35766.1 - 0.00016 21.0 0.0 0.00032 20.1 0.0 1.5 1 0 0 1 1 1 1 Rb-binding domain of kinetochore protein Cenp-F/LEK1 FANCL_C PF11793.8 ETO35766.1 - 0.045 13.9 7.2 0.071 13.3 0.1 3.4 4 0 0 4 4 4 0 FANCL C-terminal domain PB1 PF00564.24 ETO35767.1 - 0.0059 16.5 0.2 0.0084 16.0 0.2 1.3 1 0 0 1 1 1 1 PB1 domain DUF3164 PF11363.8 ETO35767.1 - 0.0096 15.6 0.0 0.012 15.2 0.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF3164) UN_NPL4 PF11543.8 ETO35767.1 - 0.021 15.3 0.0 0.03 14.8 0.0 1.3 1 0 0 1 1 1 0 Nuclear pore localisation protein NPL4 DUF1031 PF06275.11 ETO35767.1 - 0.049 13.9 0.6 0.078 13.2 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1031) DSPc PF00782.20 ETO35768.1 - 5.1e-22 78.1 0.6 2.5e-19 69.4 0.1 2.4 2 1 0 2 2 2 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO35768.1 - 0.00056 19.6 0.5 0.0014 18.2 0.5 1.7 1 1 0 1 1 1 1 Protein-tyrosine phosphatase DUF2407 PF10302.9 ETO35768.1 - 0.11 13.1 0.3 0.26 11.9 0.1 1.7 2 0 0 2 2 2 0 DUF2407 ubiquitin-like domain Pkinase PF00069.25 ETO35769.1 - 1.1e-21 77.4 2.2 3.3e-15 56.1 0.8 2.8 2 1 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35769.1 - 2.5e-15 56.5 0.4 1.4e-13 50.7 0.2 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Kdo PF06293.14 ETO35769.1 - 0.0014 18.0 1.2 0.003 16.9 0.2 2.0 2 0 0 2 2 2 1 Lipopolysaccharide kinase (Kdo/WaaP) family DUF4834 PF16118.5 ETO35769.1 - 0.0097 16.8 0.4 0.031 15.2 0.4 1.9 1 0 0 1 1 1 1 Domain of unknown function (DUF4834) Ferric_reduct PF01794.19 ETO35771.1 - 6e-10 39.3 1.7 6e-10 39.3 1.7 2.1 2 0 0 2 2 2 1 Ferric reductase like transmembrane component DUF373 PF04123.13 ETO35771.1 - 0.0014 18.2 5.6 0.38 10.2 0.0 2.9 3 0 0 3 3 3 2 Domain of unknown function (DUF373) Na_Ala_symp PF01235.17 ETO35771.1 - 0.013 14.8 1.2 0.026 13.8 0.3 1.9 2 0 0 2 2 2 0 Sodium:alanine symporter family GPR15L PF15854.5 ETO35771.1 - 0.47 10.7 2.9 0.56 10.5 0.4 2.5 2 0 0 2 2 2 0 G-protein coupled receptor ligand 15 YabA PF06156.13 ETO35772.1 - 0.0028 18.2 15.4 0.0028 18.2 15.4 2.9 2 1 1 3 3 3 1 Initiation control protein YabA HOOK PF05622.12 ETO35772.1 - 0.019 13.1 39.1 0.021 13.0 34.5 2.4 2 1 0 2 2 2 0 HOOK protein GPHR_N PF12537.8 ETO35772.1 - 0.075 13.1 12.1 0.67 10.1 3.2 3.4 3 1 0 3 3 2 0 The Golgi pH Regulator (GPHR) Family N-terminal DivIC PF04977.15 ETO35772.1 - 0.11 12.3 0.2 0.11 12.3 0.2 5.2 2 1 1 3 3 2 0 Septum formation initiator Tropomyosin PF00261.20 ETO35772.1 - 0.14 11.5 26.2 0.22 10.9 6.9 2.2 1 1 1 2 2 2 0 Tropomyosin DUF948 PF06103.11 ETO35772.1 - 0.16 12.3 11.1 2.7 8.3 0.0 3.5 3 1 0 3 3 3 0 Bacterial protein of unknown function (DUF948) CENP-F_leu_zip PF10473.9 ETO35772.1 - 0.27 11.3 41.4 1.6 8.8 4.7 3.1 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 APG17 PF04108.12 ETO35772.1 - 0.3 10.1 24.6 1.1 8.3 11.2 2.2 1 1 1 2 2 2 0 Autophagy protein Apg17 Med15 PF09606.10 ETO35772.1 - 0.59 8.7 24.3 0.6 8.7 24.3 1.1 1 0 0 1 1 1 0 ARC105 or Med15 subunit of Mediator complex non-fungal MAD PF05557.13 ETO35772.1 - 1.2 7.4 40.0 0.075 11.4 35.1 1.3 2 0 0 2 2 2 0 Mitotic checkpoint protein MutS_IV PF05190.18 ETO35772.1 - 1.3 9.4 13.3 1.5 9.2 1.3 3.3 1 1 2 3 3 3 0 MutS family domain IV TFIIA PF03153.13 ETO35772.1 - 1.4 8.8 25.3 1.7 8.5 25.3 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit MMR1 PF08505.10 ETO35772.1 - 2.4 8.4 14.2 3 8.1 14.2 1.2 1 0 0 1 1 1 0 Mitochondrial Myo2 receptor-related protein KxDL PF10241.9 ETO35772.1 - 2.7 8.3 36.4 0.081 13.2 16.7 3.1 2 1 1 3 3 3 0 Uncharacterized conserved protein CCDC-167 PF15188.6 ETO35772.1 - 2.9 8.3 19.0 2e+03 -0.8 19.0 3.0 1 1 0 1 1 1 0 Coiled-coil domain-containing protein 167 DUF5320 PF17253.2 ETO35772.1 - 3.2 8.9 0.0 3.2 8.9 0.0 4.8 2 1 3 5 5 5 0 Family of unknown function (DUF5320) LRAT PF04970.13 ETO35772.1 - 3.2 8.1 5.2 2.1 8.6 2.9 1.8 1 1 1 2 2 2 0 Lecithin retinol acyltransferase MetOD2 PF18548.1 ETO35772.1 - 4.9 7.3 14.8 12 6.0 5.8 2.9 2 1 0 2 2 2 0 Metanogen output domain 2 FUSC PF04632.12 ETO35772.1 - 5.8 5.3 11.5 7 5.1 11.5 1.1 1 0 0 1 1 1 0 Fusaric acid resistance protein family HrpB7 PF09486.10 ETO35772.1 - 5.8 7.3 22.9 77 3.6 22.9 2.7 1 1 0 1 1 1 0 Bacterial type III secretion protein (HrpB7) ATG16 PF08614.11 ETO35772.1 - 6.7 6.9 40.0 0.23 11.7 11.1 2.8 2 1 1 3 3 3 0 Autophagy protein 16 (ATG16) TMF_TATA_bd PF12325.8 ETO35772.1 - 7.4 6.8 36.9 0.21 11.8 8.6 3.9 2 1 2 4 4 4 0 TATA element modulatory factor 1 TATA binding IFT57 PF10498.9 ETO35772.1 - 8.2 5.3 29.8 2.1 7.2 24.9 2.0 1 1 1 2 2 2 0 Intra-flagellar transport protein 57 V_ATPase_I PF01496.19 ETO35772.1 - 8.7 4.1 23.3 13 3.6 23.1 1.4 1 1 0 1 1 1 0 V-type ATPase 116kDa subunit family Unstab_antitox PF09720.10 ETO35773.1 - 0.065 13.3 1.1 2.6 8.2 0.0 2.6 2 0 0 2 2 2 0 Putative addiction module component WD40 PF00400.32 ETO35774.1 - 4.1e-05 24.3 3.2 0.017 16.0 0.7 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat DUF1340 PF07067.11 ETO35774.1 - 0.0019 17.7 0.3 0.0026 17.2 0.3 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF1340) DEP PF00610.21 ETO35775.1 - 2.1e-16 59.7 0.0 3.8e-16 58.9 0.0 1.5 1 0 0 1 1 1 1 Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) Vpu PF00558.19 ETO35775.1 - 0.0097 15.7 0.2 0.018 14.8 0.2 1.5 1 0 0 1 1 1 1 Vpu protein Adenine_glyco PF03352.13 ETO35775.1 - 0.022 14.6 0.4 0.38 10.5 0.2 2.1 2 0 0 2 2 2 0 Methyladenine glycosylase C2 PF00168.30 ETO35777.1 - 1.9e-10 40.9 1.9 2e-10 40.9 0.3 2.0 2 1 0 2 2 2 1 C2 domain PALP PF00291.25 ETO35778.1 - 4.1e-09 36.3 0.1 2.2e-08 33.9 0.1 1.8 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme PALP PF00291.25 ETO35779.1 - 2.5e-12 46.8 0.0 5.8e-12 45.6 0.0 1.5 1 1 0 1 1 1 1 Pyridoxal-phosphate dependent enzyme DUF5472 PF17566.2 ETO35779.1 - 0.022 14.7 0.0 0.049 13.6 0.0 1.6 1 0 0 1 1 1 0 Family of unknown function (DUF5472) PDDEXK_5 PF11645.8 ETO35779.1 - 0.032 14.2 0.0 1.8 8.5 0.0 2.3 2 0 0 2 2 2 0 PD-(D/E)XK endonuclease CtsR PF05848.11 ETO35781.1 - 0.063 13.2 0.0 0.31 11.0 0.0 2.0 2 0 0 2 2 2 0 CtsR N-terminal HTH domain Ndc1_Nup PF09531.10 ETO35783.1 - 3.1 6.4 6.4 3.8 6.1 6.4 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup WD40 PF00400.32 ETO35784.1 - 9.3e-13 48.4 2.8 1.4e-06 28.9 0.1 3.2 3 1 0 3 3 3 2 WD domain, G-beta repeat BBS2_Mid PF14783.6 ETO35784.1 - 0.00056 19.9 1.0 0.21 11.7 0.4 2.8 1 1 1 2 2 2 2 Ciliary BBSome complex subunit 2, middle region ANAPC4_WD40 PF12894.7 ETO35784.1 - 0.0009 19.5 0.0 0.84 10.0 0.0 2.4 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35784.1 - 0.0052 15.5 0.4 0.15 10.7 0.2 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Read-through PF16814.5 ETO35784.1 - 0.044 13.6 0.0 0.057 13.2 0.0 1.1 1 0 0 1 1 1 0 Read-through domain SprB PF13573.6 ETO35784.1 - 0.41 10.5 10.9 1.6 8.6 0.3 3.2 3 0 0 3 3 3 0 SprB repeat SUIM_assoc PF16619.5 ETO35785.1 - 0.009 16.1 5.7 0.019 15.0 5.4 1.7 1 1 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Rsc14 PF08586.10 ETO35785.1 - 0.16 12.8 4.9 16 6.4 0.3 3.3 2 1 0 3 3 3 0 RSC complex, Rsc14/Ldb7 subunit Androgen_recep PF02166.16 ETO35785.1 - 8.1 5.2 7.1 10 4.8 7.1 1.1 1 0 0 1 1 1 0 Androgen receptor IF4E PF01652.18 ETO35786.1 - 3.2e-40 137.5 3.4 4.4e-40 137.1 3.4 1.2 1 0 0 1 1 1 1 Eukaryotic initiation factor 4E DUF3450 PF11932.8 ETO35787.1 - 0.11 11.8 13.6 0.016 14.5 9.9 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3450) APG6_N PF17675.1 ETO35787.1 - 1.2 9.7 13.9 0.59 10.7 8.1 2.3 1 1 1 2 2 2 0 Apg6 coiled-coil region GIT_CC PF16559.5 ETO35787.1 - 7.3 6.5 12.1 12 5.8 2.3 2.6 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor NOP5NT PF08156.13 ETO35788.1 - 0.2 12.1 3.0 5.3 7.5 1.4 2.1 2 0 0 2 2 2 0 NOP5NT (NUC127) domain Herpes_pp85 PF04637.12 ETO35790.1 - 1.9 6.8 8.3 3 6.1 8.3 1.2 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Raffinose_syn PF05691.12 ETO35791.1 - 0.0019 16.1 0.7 0.0041 15.0 0.7 1.5 1 1 0 1 1 1 1 Raffinose synthase or seed imbibition protein Sip1 BRE1 PF08647.11 ETO35791.1 - 0.012 15.6 15.9 0.14 12.3 2.7 3.0 3 0 0 3 3 3 0 BRE1 E3 ubiquitin ligase TPR_MLP1_2 PF07926.12 ETO35791.1 - 0.013 15.6 1.8 0.013 15.6 1.8 4.5 2 1 1 4 4 4 0 TPR/MLP1/MLP2-like protein T2SSM PF04612.12 ETO35791.1 - 0.051 13.6 3.0 0.54 10.3 0.9 2.7 2 0 0 2 2 2 0 Type II secretion system (T2SS), protein M MerR-DNA-bind PF09278.11 ETO35791.1 - 0.06 13.9 5.4 5.2 7.7 0.0 3.5 2 1 1 3 3 3 0 MerR, DNA binding DUF2407_C PF13373.6 ETO35791.1 - 0.084 13.0 3.9 0.86 9.8 1.9 2.9 2 0 0 2 2 2 0 DUF2407 C-terminal domain SOAR PF16533.5 ETO35791.1 - 0.093 12.7 5.2 0.28 11.2 5.2 1.8 1 0 0 1 1 1 0 STIM1 Orai1-activating region CENP-F_leu_zip PF10473.9 ETO35791.1 - 0.093 12.7 13.3 0.41 10.7 0.6 3.3 2 1 1 3 3 3 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 PHA_synth_III_E PF09712.10 ETO35791.1 - 0.22 10.6 4.6 0.14 11.2 2.2 2.0 1 1 1 2 2 2 0 Poly(R)-hydroxyalkanoic acid synthase subunit (PHA_synth_III_E) Ndc1_Nup PF09531.10 ETO35791.1 - 0.25 10.0 10.1 1.6 7.4 2.4 2.5 2 0 0 2 2 2 0 Nucleoporin protein Ndc1-Nup FRB_dom PF08771.11 ETO35791.1 - 0.31 11.5 3.1 0.31 11.5 0.7 2.3 2 1 0 2 2 2 0 FKBP12-rapamycin binding domain RNase_J_C PF17770.1 ETO35791.1 - 0.43 11.7 4.4 28 5.9 0.9 3.1 2 0 0 2 2 2 0 Ribonuclease J C-terminal domain PRKG1_interact PF15898.5 ETO35791.1 - 0.65 10.9 16.7 0.045 14.6 7.6 2.9 3 0 0 3 3 3 0 cGMP-dependent protein kinase interacting domain DUF4806 PF16064.5 ETO35791.1 - 1.1 9.5 4.4 0.56 10.5 1.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4806) DUF4140 PF13600.6 ETO35791.1 - 1.2 9.6 9.5 12 6.4 4.0 3.6 2 1 1 3 3 3 0 N-terminal domain of unknown function (DUF4140) ABC_tran_CTD PF16326.5 ETO35791.1 - 3.5 7.9 13.4 7.2 6.9 6.2 2.8 3 0 0 3 3 2 0 ABC transporter C-terminal domain FliJ PF02050.16 ETO35791.1 - 8.4 6.6 15.7 8.6 6.6 6.1 3.5 1 1 1 3 3 3 0 Flagellar FliJ protein WXG100 PF06013.12 ETO35791.1 - 8.5 6.7 9.3 53 4.1 1.2 3.7 2 1 0 3 3 3 0 Proteins of 100 residues with WXG DUF2726 PF10881.8 ETO35793.1 - 0.11 12.4 0.0 0.17 11.8 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2726) eIF3g PF12353.8 ETO35793.1 - 0.66 10.4 4.4 0.17 12.2 1.1 1.9 2 1 0 2 2 2 0 Eukaryotic translation initiation factor 3 subunit G Cadherin_C_2 PF16492.5 ETO35794.1 - 0.0033 18.1 0.0 0.0064 17.2 0.0 1.7 1 1 0 1 1 1 1 Cadherin cytoplasmic C-terminal TMEM154 PF15102.6 ETO35794.1 - 0.005 16.7 0.3 0.005 16.7 0.3 2.6 1 1 1 2 2 2 1 TMEM154 protein family DUF4133 PF13571.6 ETO35794.1 - 0.024 15.0 1.0 0.037 14.4 1.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4133) EphA2_TM PF14575.6 ETO35794.1 - 0.029 15.2 0.2 0.054 14.4 0.2 1.8 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain Mid2 PF04478.12 ETO35794.1 - 0.052 13.4 0.2 0.052 13.4 0.2 2.2 4 0 0 4 4 4 0 Mid2 like cell wall stress sensor SID-1_RNA_chan PF13965.6 ETO35794.1 - 0.14 10.5 0.0 0.16 10.4 0.0 1.3 1 1 0 1 1 1 0 dsRNA-gated channel SID-1 Orthoreo_P10 PF07204.11 ETO35794.1 - 0.18 11.8 0.1 0.29 11.1 0.1 1.3 1 0 0 1 1 1 0 Orthoreovirus membrane fusion protein p10 Orf78 PF06024.12 ETO35794.1 - 1 9.7 0.0 1 9.7 0.0 2.8 2 1 1 3 3 3 0 Orf78 (ac78) HsbA PF12296.8 ETO35797.1 - 0.02 15.3 0.0 0.18 12.2 0.0 1.9 2 0 0 2 2 2 0 Hydrophobic surface binding protein A PIN PF01850.21 ETO35797.1 - 0.06 13.9 0.4 0.071 13.6 0.4 1.1 1 0 0 1 1 1 0 PIN domain UDPGT PF00201.18 ETO35798.1 - 0.11 11.2 1.0 0.14 11.0 1.0 1.0 1 0 0 1 1 1 0 UDP-glucoronosyl and UDP-glucosyl transferase CXCL17 PF15211.6 ETO35798.1 - 3.2 8.6 10.4 0.11 13.2 1.5 2.2 1 1 1 2 2 2 0 VEGF co-regulated chemokine 1 Receptor_2B4 PF11465.8 ETO35799.1 - 0.05 13.8 4.1 6.2 7.1 0.0 2.7 2 0 0 2 2 2 0 Natural killer cell receptor 2B4 MerR-DNA-bind PF09278.11 ETO35799.1 - 0.09 13.3 0.5 0.22 12.1 0.5 1.7 1 0 0 1 1 1 0 MerR, DNA binding Menin PF05053.13 ETO35799.1 - 0.41 9.0 7.0 0.57 8.5 7.0 1.3 1 0 0 1 1 1 0 Menin FAM60A PF15396.6 ETO35799.1 - 5.3 7.0 9.6 9.4 6.2 9.6 1.4 1 0 0 1 1 1 0 Protein Family FAM60A ATP-grasp_4 PF13535.6 ETO35800.1 - 1.6e-08 34.3 0.0 0.00062 19.4 0.0 2.7 2 0 0 2 2 2 2 ATP-grasp domain CPSase_L_D2 PF02786.17 ETO35800.1 - 1.8e-06 27.6 0.0 0.015 14.8 0.0 2.3 2 0 0 2 2 2 2 Carbamoyl-phosphate synthase L chain, ATP binding domain ATPgrasp_Ter PF15632.6 ETO35800.1 - 0.00032 20.5 0.0 0.058 13.1 0.0 2.4 2 0 0 2 2 2 2 ATP-grasp in the biosynthetic pathway with Ter operon ATP-grasp_3 PF02655.14 ETO35800.1 - 0.0042 17.1 0.0 0.29 11.2 0.0 2.4 2 0 0 2 2 2 1 ATP-grasp domain RimK PF08443.11 ETO35800.1 - 0.01 15.5 0.0 0.02 14.5 0.0 1.4 1 0 0 1 1 1 0 RimK-like ATP-grasp domain Ins134_P3_kin PF05770.11 ETO35800.1 - 0.075 12.5 0.0 0.19 11.2 0.0 1.6 1 0 0 1 1 1 0 Inositol 1,3,4-trisphosphate 5/6-kinase ATP-grasp domain DUF4834 PF16118.5 ETO35800.1 - 1.1 10.3 5.6 0.69 10.9 2.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) ERAP1_C PF11838.8 ETO35803.1 - 1.4e-49 169.3 0.0 2.9e-42 145.3 0.0 2.0 1 1 1 2 2 2 2 ERAP1-like C-terminal domain DUF3437 PF11919.8 ETO35804.1 - 0.096 12.6 0.0 0.17 11.9 0.0 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3437) DUF502 PF04367.13 ETO35804.1 - 0.14 12.0 1.5 0.56 10.1 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF502) LRR_8 PF13855.6 ETO35805.1 - 0.00072 19.3 11.2 0.0044 16.7 1.8 2.3 1 1 2 3 3 3 2 Leucine rich repeat LRR_6 PF13516.6 ETO35805.1 - 0.0031 17.4 3.9 0.64 10.2 0.1 3.8 3 0 0 3 3 3 2 Leucine Rich repeat SecB PF02556.14 ETO35805.1 - 0.058 13.3 0.8 0.22 11.4 0.1 2.1 2 0 0 2 2 2 0 Preprotein translocase subunit SecB XRN_M PF17846.1 ETO35806.1 - 8.8e-23 81.0 1.6 1.1e-22 80.6 1.6 1.2 1 0 0 1 1 1 1 Xrn1 helical domain XRN_N PF03159.18 ETO35806.1 - 0.028 13.9 0.1 0.028 13.9 0.1 2.1 2 0 0 2 2 2 0 XRN 5'-3' exonuclease N-terminus Microtub_bind PF13931.6 ETO35806.1 - 3.6 8.0 6.1 5.9 7.3 6.1 1.3 1 0 0 1 1 1 0 Kinesin-associated microtubule-binding WD40 PF00400.32 ETO35807.1 - 3.2e-39 132.2 32.3 3.2e-07 30.9 2.9 7.5 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35807.1 - 2.8e-10 40.4 4.3 0.066 13.5 0.0 5.5 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35807.1 - 2.4e-09 36.4 9.4 0.034 12.8 0.1 5.5 1 1 3 5 5 5 4 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO35807.1 - 0.00019 21.4 0.6 0.93 9.6 0.0 4.2 3 1 1 4 4 4 1 Ciliary BBSome complex subunit 2, middle region DNA_primase_S PF01896.19 ETO35808.1 - 2.6e-43 148.1 0.9 4.3e-43 147.4 0.9 1.4 1 0 0 1 1 1 1 DNA primase small subunit Alpha-2-MRAP_N PF06400.11 ETO35808.1 - 0.039 13.9 0.5 0.039 13.9 0.5 1.9 2 0 0 2 2 2 0 Alpha-2-macroglobulin RAP, N-terminal domain Pes-10 PF07149.11 ETO35810.1 - 0.00081 18.6 3.5 0.0012 18.0 3.5 1.2 1 0 0 1 1 1 1 Pes-10 GCIP PF13324.6 ETO35810.1 - 0.5 9.9 7.5 0.16 11.6 3.9 1.9 2 0 0 2 2 2 0 Grap2 and cyclin-D-interacting CDC45 PF02724.14 ETO35810.1 - 1.5 7.0 9.6 2.8 6.1 9.6 1.3 1 0 0 1 1 1 0 CDC45-like protein S-antigen PF05756.11 ETO35810.1 - 3.2 8.2 16.8 0.074 13.4 8.0 2.5 2 0 0 2 2 2 0 S-antigen protein Pox_A3L PF05288.11 ETO35811.1 - 0.049 13.6 0.8 0.066 13.2 0.7 1.3 1 1 0 1 1 1 0 Poxvirus A3L Protein WD40 PF00400.32 ETO35812.1 - 6.5e-58 191.4 19.4 1.2e-09 38.7 0.5 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35812.1 - 1.3e-24 86.3 3.1 0.0031 17.8 0.1 6.2 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35812.1 - 1.7e-11 44.0 0.1 0.00012 21.5 0.1 3.2 2 1 1 3 3 3 3 WD40-like domain Ge1_WD40 PF16529.5 ETO35812.1 - 7.1e-09 35.1 0.0 4.9 6.0 0.0 5.9 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO35812.1 - 1.2e-06 27.3 1.8 0.019 13.5 0.1 3.4 1 1 3 4 4 4 3 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO35812.1 - 3.1e-05 24.0 6.4 0.15 12.1 0.2 4.9 1 1 3 5 5 5 1 Family of unknown function (DUF5570) PQQ PF01011.21 ETO35812.1 - 0.0001 22.0 0.0 2.2 8.4 0.0 4.7 5 0 0 5 5 5 1 PQQ enzyme repeat PQQ_2 PF13360.6 ETO35812.1 - 0.00016 21.4 1.3 0.00071 19.2 0.4 2.2 2 0 0 2 2 2 1 PQQ-like domain Me-amine-dh_H PF06433.11 ETO35812.1 - 0.00018 20.5 0.1 0.02 13.7 0.0 2.8 1 1 1 3 3 3 1 Methylamine dehydrogenase heavy chain (MADH) Resistin PF06954.11 ETO35812.1 - 0.021 15.4 0.5 4.5 7.9 0.4 3.1 2 1 1 3 3 3 0 Resistin PD40 PF07676.12 ETO35812.1 - 0.025 14.5 9.5 4.6 7.3 0.1 4.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO35812.1 - 0.025 13.3 9.9 0.69 8.6 0.4 4.0 1 1 3 4 4 4 0 Nup133 N terminal like DUF4265 PF14085.6 ETO35812.1 - 0.16 12.0 0.2 28 4.7 0.0 3.4 2 2 1 3 3 3 0 Domain of unknown function (DUF4265) Herpes_BLRF2 PF05812.12 ETO35815.1 - 0.0052 16.9 1.7 0.012 15.7 1.7 1.6 1 0 0 1 1 1 1 Herpesvirus BLRF2 protein bZIP_1 PF00170.21 ETO35815.1 - 0.012 15.6 6.5 0.012 15.6 6.5 2.1 2 0 0 2 2 2 0 bZIP transcription factor SOGA PF11365.8 ETO35815.1 - 0.022 15.9 0.5 0.022 15.9 0.5 2.6 3 0 0 3 3 3 0 Protein SOGA TSC22 PF01166.18 ETO35815.1 - 0.024 14.9 4.5 0.064 13.6 4.5 1.7 1 0 0 1 1 1 0 TSC-22/dip/bun family DivIC PF04977.15 ETO35815.1 - 0.044 13.5 3.3 0.09 12.6 3.3 1.5 1 0 0 1 1 1 0 Septum formation initiator bZIP_2 PF07716.15 ETO35815.1 - 0.24 11.5 9.3 0.33 11.1 6.6 2.5 3 0 0 3 3 3 0 Basic region leucine zipper WD40 PF00400.32 ETO35816.1 - 9.4e-45 149.7 24.6 3.1e-10 40.5 0.6 6.6 6 1 1 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35816.1 - 9.4e-16 57.9 0.4 0.0042 17.4 0.3 5.8 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35816.1 - 2.1e-13 50.0 0.6 0.0049 15.9 0.2 5.1 1 1 4 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO35816.1 - 1.6e-06 27.9 0.2 1.8 8.6 0.0 4.9 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Proteasome_A_N PF10584.9 ETO35816.1 - 1.2e-05 24.9 0.9 3.8 7.3 0.0 4.7 5 0 0 5 5 5 2 Proteasome subunit A N-terminal signature Nup160 PF11715.8 ETO35816.1 - 0.00062 18.5 1.3 0.67 8.5 0.2 2.6 1 1 0 2 2 2 2 Nucleoporin Nup120/160 DUF727 PF05303.12 ETO35816.1 - 0.0016 18.5 0.6 24 5.1 0.0 5.3 3 2 3 6 6 6 0 Protein of unknown function (DUF727) WD40_like PF17005.5 ETO35816.1 - 0.0021 17.4 0.0 0.38 10.0 0.0 2.8 1 1 2 3 3 3 1 WD40-like domain Nbas_N PF15492.6 ETO35816.1 - 0.0043 16.4 0.1 0.16 11.3 0.0 3.0 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO35816.1 - 0.024 13.4 0.0 20 3.8 0.0 3.7 1 1 1 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Img2 PF05046.14 ETO35817.1 - 7.1e-07 29.4 0.5 1e-05 25.8 0.5 2.4 1 1 0 1 1 1 1 Mitochondrial large subunit ribosomal protein (Img2) DUF3313 PF11769.8 ETO35817.1 - 0.01 15.7 0.0 0.017 15.0 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3313) LRR_8 PF13855.6 ETO35818.1 - 9.5e-11 41.3 24.2 0.003 17.3 5.2 4.7 5 0 0 5 5 5 4 Leucine rich repeat LRR_1 PF00560.33 ETO35818.1 - 0.015 15.8 20.3 38 5.4 0.0 8.2 8 1 0 8 8 8 0 Leucine Rich Repeat G-alpha PF00503.20 ETO35819.1 - 1.3e-32 113.4 10.7 3.9e-16 59.2 0.8 2.5 2 1 0 2 2 2 2 G-protein alpha subunit Antiterm PF03589.13 ETO35819.1 - 0.11 12.8 0.0 0.31 11.4 0.0 1.7 1 0 0 1 1 1 0 Antitermination protein EF-hand_7 PF13499.6 ETO35820.1 - 0.046 14.2 0.1 0.078 13.4 0.1 1.5 1 0 0 1 1 1 0 EF-hand domain pair EF-hand_6 PF13405.6 ETO35820.1 - 0.072 13.1 0.0 0.15 12.1 0.0 1.5 1 0 0 1 1 1 0 EF-hand domain V_ATPase_I PF01496.19 ETO35821.1 - 9.1e-10 37.1 4.8 9.1e-10 37.1 4.8 1.3 2 0 0 2 2 2 1 V-type ATPase 116kDa subunit family DUF3040 PF11239.8 ETO35821.1 - 0.26 11.6 1.0 0.89 9.9 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF3040) YopX PF09643.10 ETO35823.1 - 0.018 15.1 0.5 0.031 14.3 0.5 1.5 1 0 0 1 1 1 0 YopX protein Exo_endo_phos_2 PF14529.6 ETO35823.1 - 0.067 13.0 0.0 0.13 12.1 0.0 1.5 1 0 0 1 1 1 0 Endonuclease-reverse transcriptase VPS13 PF16908.5 ETO35824.1 - 9.4e-11 42.0 0.4 4.2e-10 39.8 0.4 2.1 1 1 0 1 1 1 1 Vacuolar sorting-associated protein 13, N-terminal VPS13_mid_rpt PF16910.5 ETO35824.1 - 9.3e-08 31.8 1.2 0.00098 18.6 0.2 2.5 1 1 1 2 2 2 2 Repeating coiled region of VPS13 TPR_11 PF13414.6 ETO35826.1 - 1.1e-19 69.8 2.1 9.1e-06 25.3 0.1 4.8 5 0 0 5 5 5 3 TPR repeat TPR_1 PF00515.28 ETO35826.1 - 7.2e-17 60.4 1.1 0.00042 20.0 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35826.1 - 8.3e-13 47.8 2.4 0.011 16.0 0.0 4.5 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35826.1 - 8.8e-13 47.3 2.1 0.00089 19.2 0.0 5.0 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO35826.1 - 3e-12 46.3 0.2 0.2 12.6 0.0 5.0 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO35826.1 - 2.7e-11 43.9 0.0 0.00016 22.2 0.0 3.1 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35826.1 - 3.5e-08 33.0 0.1 1 9.7 0.0 4.5 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO35826.1 - 2.1e-05 24.9 0.4 0.055 14.0 0.0 3.4 3 1 0 3 3 3 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO35826.1 - 0.00012 22.2 3.3 0.35 11.2 0.7 3.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35826.1 - 0.00014 21.6 0.2 5.4 7.3 0.0 4.7 5 0 0 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35826.1 - 0.029 15.0 0.7 31 5.5 0.0 4.3 5 0 0 5 5 5 0 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO35826.1 - 0.29 11.4 3.0 0.82 9.9 0.1 2.5 2 1 0 2 2 2 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_2 PF07719.17 ETO35827.1 - 0.005 16.9 0.0 0.011 15.7 0.0 1.6 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35827.1 - 0.16 11.8 0.0 0.36 10.7 0.0 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat LINES_C PF14695.6 ETO35828.1 - 4.5e-13 48.4 0.6 4.5e-13 48.4 0.6 1.8 2 0 0 2 2 2 1 Lines C-terminus LINES_N PF14694.6 ETO35828.1 - 6e-11 42.4 1.3 1.1e-10 41.5 1.3 1.4 1 0 0 1 1 1 1 Lines N-terminus PTR PF12789.7 ETO35828.1 - 0.063 13.3 2.0 0.091 12.8 0.1 2.3 2 0 0 2 2 2 0 Phage tail repeat like Ndc1_Nup PF09531.10 ETO35828.1 - 6.3 5.4 12.7 11 4.5 12.7 1.3 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RRM_1 PF00076.22 ETO35830.1 - 2.2e-18 65.8 0.1 0.0004 20.2 0.0 4.4 4 0 0 4 4 4 4 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_3 PF08777.11 ETO35830.1 - 0.018 15.0 0.1 0.62 10.1 0.0 3.1 3 1 0 3 3 3 0 RNA binding motif RRM_Rrp7 PF17799.1 ETO35830.1 - 0.028 14.2 0.0 0.34 10.7 0.0 2.5 3 0 0 3 3 3 0 Rrp7 RRM-like N-terminal domain Peptidase_S10 PF00450.22 ETO35831.1 - 1.2e-21 77.7 0.4 1.3e-21 77.5 0.4 1.0 1 0 0 1 1 1 1 Serine carboxypeptidase MBOAT_2 PF13813.6 ETO35834.1 - 3.9e-06 27.0 3.6 0.0028 17.9 3.5 2.4 1 1 0 1 1 1 1 Membrane bound O-acyl transferase family 7tm_1 PF00001.21 ETO35836.1 - 6.1e-05 22.5 0.0 7.6e-05 22.2 0.0 1.1 1 0 0 1 1 1 1 7 transmembrane receptor (rhodopsin family) GPR_Gpa2_C PF11970.8 ETO35836.1 - 0.00022 21.2 0.7 0.00022 21.2 0.7 1.8 2 0 0 2 2 2 1 G protein-coupled glucose receptor regulating Gpa2 C-term DUF3742 PF12553.8 ETO35836.1 - 0.11 12.6 0.0 0.18 11.9 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3742) BatD PF13584.6 ETO35836.1 - 0.18 10.6 0.0 0.24 10.2 0.0 1.1 1 0 0 1 1 1 0 Oxygen tolerance DUF1676 PF07898.13 ETO35836.1 - 0.25 11.4 1.1 2.5 8.1 2.1 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) CDC45 PF02724.14 ETO35837.1 - 0.00017 20.0 11.0 0.00025 19.5 11.0 1.2 1 0 0 1 1 1 1 CDC45-like protein RTT107_BRCT_5 PF16770.5 ETO35837.1 - 0.077 12.9 0.1 4.7 7.2 0.1 2.7 2 0 0 2 2 2 0 Regulator of Ty1 transposition protein 107 BRCT domain RNA_pol_Rpc4 PF05132.14 ETO35837.1 - 0.1 13.0 2.4 0.2 12.1 2.4 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 RPA43_OB PF17875.1 ETO35837.1 - 0.11 13.2 9.9 0.25 12.0 9.9 1.5 1 0 0 1 1 1 0 RPA43 OB domain in RNA Pol I DNA_pol_phi PF04931.13 ETO35837.1 - 0.12 10.4 21.1 0.21 9.7 21.1 1.3 1 0 0 1 1 1 0 DNA polymerase phi Nop14 PF04147.12 ETO35837.1 - 0.12 10.5 18.7 0.24 9.6 18.7 1.4 1 0 0 1 1 1 0 Nop14-like family BUD22 PF09073.10 ETO35837.1 - 0.16 11.3 17.9 0.25 10.7 17.9 1.2 1 0 0 1 1 1 0 BUD22 FYDLN_acid PF09538.10 ETO35837.1 - 0.18 12.5 14.8 0.56 10.9 14.8 1.8 1 0 0 1 1 1 0 Protein of unknown function (FYDLN_acid) DUF913 PF06025.12 ETO35837.1 - 0.24 10.3 4.7 0.053 12.5 1.1 1.7 2 0 0 2 2 2 0 Domain of Unknown Function (DUF913) SDA1 PF05285.12 ETO35837.1 - 0.26 10.7 18.4 0.42 10.0 18.4 1.3 1 0 0 1 1 1 0 SDA1 Pox_Ag35 PF03286.14 ETO35837.1 - 0.27 11.0 15.4 0.53 10.0 15.4 1.4 1 0 0 1 1 1 0 Pox virus Ag35 surface protein CPSF100_C PF13299.6 ETO35837.1 - 0.53 10.4 6.8 1.1 9.4 6.8 1.5 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal RNA_pol_3_Rpc31 PF11705.8 ETO35837.1 - 0.56 10.4 26.3 0.15 12.3 21.9 2.1 2 0 0 2 2 2 0 DNA-directed RNA polymerase III subunit Rpc31 FAM176 PF14851.6 ETO35837.1 - 0.73 9.5 15.0 2.1 8.0 15.0 1.7 1 0 0 1 1 1 0 FAM176 family SpoIIIAH PF12685.7 ETO35837.1 - 1.5 8.6 18.9 0.21 11.4 7.9 2.6 3 0 0 3 3 3 0 SpoIIIAH-like protein DUF4637 PF15470.6 ETO35837.1 - 3.7 7.2 14.9 8.6 6.1 14.9 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4637) CobT PF06213.12 ETO35837.1 - 9.1 5.6 17.5 16 4.8 17.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT AAA_11 PF13086.6 ETO35839.1 - 0.00077 19.3 1.6 0.0027 17.5 0.0 1.9 1 1 1 2 2 2 1 AAA domain Ac76 PF05814.11 ETO35839.1 - 0.093 12.8 2.5 0.16 12.0 2.5 1.4 1 0 0 1 1 1 0 Orf76 (Ac76) Methyltr_RsmB-F PF01189.17 ETO35840.1 - 4.5e-25 88.5 0.2 4.6e-12 46.0 0.0 2.4 2 0 0 2 2 2 2 16S rRNA methyltransferase RsmB/F Methyltransf_31 PF13847.6 ETO35840.1 - 2.8e-05 24.0 0.1 0.0007 19.4 0.0 2.4 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO35840.1 - 4.6e-05 24.0 0.0 0.00016 22.3 0.0 2.0 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ETO35840.1 - 6.2e-05 23.2 0.2 0.00022 21.4 0.2 2.0 1 1 0 1 1 1 1 FtsJ-like methyltransferase Methyltransf_23 PF13489.6 ETO35840.1 - 0.00026 20.8 0.0 0.0012 18.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO35840.1 - 0.02 14.2 0.0 0.039 13.3 0.0 1.5 1 0 0 1 1 1 0 ubiE/COQ5 methyltransferase family MTS PF05175.14 ETO35840.1 - 0.11 12.0 0.0 0.43 10.1 0.0 1.9 2 0 0 2 2 2 0 Methyltransferase small domain PCMT PF01135.19 ETO35840.1 - 0.14 11.9 0.0 0.23 11.2 0.0 1.5 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) GRIM-19 PF06212.12 ETO35841.1 - 0.09 12.7 0.1 0.11 12.4 0.1 1.2 1 0 0 1 1 1 0 GRIM-19 protein Pox_polyA_pol_N PF12630.7 ETO35841.1 - 0.16 12.3 3.3 0.25 11.7 3.3 1.4 1 1 0 1 1 1 0 Poxvirus poly(A) polymerase N-terminal domain BP28CT PF08146.12 ETO35842.1 - 0.046 13.6 0.2 0.053 13.4 0.2 1.2 1 0 0 1 1 1 0 BP28CT (NUC211) domain Pox_A14 PF05767.12 ETO35843.1 - 3.4 7.9 8.3 2.2 8.5 5.6 2.1 1 1 1 2 2 2 0 Poxvirus virion envelope protein A14 Syndecan PF01034.20 ETO35843.1 - 5.1 7.1 7.5 0.26 11.2 0.3 2.4 3 0 0 3 3 3 0 Syndecan domain ERGIC_N PF13850.6 ETO35843.1 - 8.8 6.7 9.7 54 4.2 9.3 2.4 1 1 0 1 1 1 0 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Sina PF03145.16 ETO35844.1 - 2.5e-06 27.6 7.4 0.00038 20.5 1.6 2.7 1 1 1 2 2 2 2 Seven in absentia protein family zf-TRAF PF02176.18 ETO35844.1 - 0.00022 21.9 2.7 0.00022 21.9 2.7 2.7 2 0 0 2 2 2 1 TRAF-type zinc finger DUF3827 PF12877.7 ETO35847.1 - 0.074 11.4 5.0 0.089 11.2 5.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Lsr2 PF11774.8 ETO35847.1 - 0.44 10.7 6.7 13 6.0 6.7 2.2 1 1 0 1 1 1 0 Lsr2 MAS20 PF02064.15 ETO35847.1 - 1.6 8.8 5.7 2.5 8.2 5.6 1.4 1 1 0 1 1 1 0 MAS20 protein import receptor Peptidase_S49_N PF08496.10 ETO35847.1 - 4.6 7.3 7.9 6.7 6.8 7.6 1.4 1 1 0 1 1 1 0 Peptidase family S49 N-terminal CHAT PF12770.7 ETO35848.1 - 2.7e-11 43.4 0.3 5.6e-11 42.4 0.3 1.5 1 0 0 1 1 1 1 CHAT domain EFG_II PF14492.6 ETO35848.1 - 0.02 15.0 0.1 0.083 13.0 0.0 2.1 2 0 0 2 2 2 0 Elongation Factor G, domain II Peptidase_C25 PF01364.18 ETO35848.1 - 0.11 11.7 0.0 0.22 10.7 0.0 1.4 1 0 0 1 1 1 0 Peptidase family C25 RNA_pol_Rpc4 PF05132.14 ETO35849.1 - 0.27 11.7 5.8 0.44 11.0 5.8 1.4 1 0 0 1 1 1 0 RNA polymerase III RPC4 Tim54 PF11711.8 ETO35849.1 - 0.82 8.4 7.1 0.96 8.2 7.1 1.2 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 Menin PF05053.13 ETO35849.1 - 1.7 6.9 18.8 2.2 6.5 18.8 1.2 1 0 0 1 1 1 0 Menin CDC45 PF02724.14 ETO35849.1 - 2.6 6.2 13.4 2.7 6.2 13.4 1.0 1 0 0 1 1 1 0 CDC45-like protein Neur_chan_memb PF02932.16 ETO35849.1 - 3.2 7.7 5.0 3.3 7.7 5.0 1.1 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Zip PF02535.22 ETO35849.1 - 3.5 6.7 16.1 4.1 6.5 16.1 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO35849.1 - 4.4 6.0 17.7 4.9 5.8 17.7 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO35849.1 - 5.6 5.6 19.6 6.3 5.5 19.6 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 V_ATPase_I PF01496.19 ETO35849.1 - 6.2 4.6 10.9 7.1 4.4 10.9 1.0 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family RP-C_C PF11800.8 ETO35849.1 - 9.5 6.3 11.8 15 5.6 11.8 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region INTS2 PF14750.6 ETO35851.1 - 0.035 11.7 1.3 0.17 9.4 0.2 2.0 2 0 0 2 2 2 0 Integrator complex subunit 2 MINDY_DUB PF04424.13 ETO35851.1 - 0.065 13.3 0.3 0.4 10.7 0.3 2.1 2 1 0 2 2 2 0 MINDY deubiquitinase Fe_dep_repr_C PF02742.15 ETO35851.1 - 0.25 11.5 1.1 0.88 9.7 0.0 2.4 2 1 1 3 3 3 0 Iron dependent repressor, metal binding and dimerisation domain PTS_EIIC PF02378.18 ETO35852.1 - 0.024 13.7 0.0 0.033 13.2 0.0 1.1 1 0 0 1 1 1 0 Phosphotransferase system, EIIC WD40 PF00400.32 ETO35853.1 - 3e-67 220.9 16.3 6.8e-09 36.2 1.5 7.0 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35853.1 - 9.1e-22 77.2 5.1 0.0052 17.0 0.0 6.3 1 1 5 6 6 6 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35853.1 - 1e-18 67.4 1.2 0.0037 16.3 0.0 6.1 1 1 5 6 6 6 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35853.1 - 3.7e-10 39.6 0.6 0.017 14.5 0.0 3.7 1 1 3 4 4 4 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO35853.1 - 2e-09 36.5 1.9 3.3e-06 25.9 0.1 3.0 1 1 2 3 3 3 2 Cytochrome D1 heme domain Nup160 PF11715.8 ETO35853.1 - 3.7e-06 25.9 11.0 0.074 11.7 0.6 5.4 1 1 4 5 5 5 3 Nucleoporin Nup120/160 SGL PF08450.12 ETO35853.1 - 2.6e-05 24.0 1.2 0.07 12.7 0.0 3.1 1 1 1 3 3 3 2 SMP-30/Gluconolactonase/LRE-like region PD40 PF07676.12 ETO35853.1 - 0.0008 19.3 7.9 8.1 6.5 0.0 5.9 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Coatomer_WDAD PF04053.14 ETO35853.1 - 0.0022 17.1 3.6 0.29 10.1 0.5 3.2 1 1 2 3 3 3 1 Coatomer WD associated region Nbas_N PF15492.6 ETO35853.1 - 0.0064 15.9 2.2 3.8 6.8 0.0 3.4 1 1 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal GATase PF00117.28 ETO35853.1 - 0.054 13.3 0.3 19 5.0 0.0 3.6 2 2 2 4 4 4 0 Glutamine amidotransferase class-I Nucleoporin_N PF08801.11 ETO35853.1 - 0.058 12.1 14.1 5.1 5.7 0.1 5.2 1 1 4 5 5 5 0 Nup133 N terminal like HARP PF07443.13 ETO35853.1 - 0.099 12.3 2.4 2.5 7.8 0.0 4.1 6 0 0 6 6 6 0 HepA-related protein (HARP) Kelch_5 PF13854.6 ETO35854.1 - 0.0036 17.3 0.7 0.0075 16.2 0.2 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO35854.1 - 0.016 14.8 0.1 0.039 13.5 0.1 1.6 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 ETO35854.1 - 0.024 14.9 0.0 0.94 9.9 0.0 2.4 2 0 0 2 2 2 0 Kelch motif BUD22 PF09073.10 ETO35856.1 - 0.0028 17.1 20.5 0.0033 16.9 20.5 1.0 1 0 0 1 1 1 1 BUD22 Otopetrin PF03189.13 ETO35856.1 - 0.026 13.3 0.0 0.048 12.5 0.0 1.4 1 1 0 1 1 1 0 Otopetrin Paf1 PF03985.13 ETO35856.1 - 0.15 11.0 22.8 0.21 10.6 22.8 1.2 1 0 0 1 1 1 0 Paf1 TERB2 PF15101.6 ETO35856.1 - 0.27 11.2 10.0 0.51 10.4 10.0 1.4 1 0 0 1 1 1 0 Telomere-associated protein TERB2 RR_TM4-6 PF06459.12 ETO35856.1 - 0.3 10.9 22.2 0.39 10.5 22.2 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 TMEM144 PF07857.12 ETO35856.1 - 0.42 9.5 2.5 0.8 8.6 2.5 1.5 1 0 0 1 1 1 0 Transmembrane family, TMEM144 of transporters DUF4746 PF15928.5 ETO35856.1 - 2.4 7.5 19.1 3 7.2 19.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) CCDC66 PF15236.6 ETO35856.1 - 4.5 7.1 31.5 8.4 6.2 31.5 1.3 1 0 0 1 1 1 0 Coiled-coil domain-containing protein 66 DUF4834 PF16118.5 ETO35856.1 - 4.8 8.2 23.7 1.2 10.2 11.9 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF4834) ALMT PF11744.8 ETO35856.1 - 5.5 5.7 16.2 7.1 5.3 16.2 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter BIRC6 PF12356.8 ETO35856.1 - 6 6.3 8.2 5.2 6.5 1.2 2.4 2 1 0 2 2 2 0 Baculoviral IAP repeat-containing protein 6 MAP17 PF15807.5 ETO35856.1 - 8.1 6.7 16.2 97 3.2 14.7 2.4 2 0 0 2 2 2 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Trypan_PARP PF05887.11 ETO35856.1 - 9.3 6.2 18.0 0.4 10.7 11.9 1.8 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) WD40 PF00400.32 ETO35857.1 - 1.2e-08 35.5 4.1 0.00089 20.0 0.0 2.6 2 0 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 ETO35858.1 - 3.4e-39 132.1 35.7 7.4e-08 32.9 0.3 7.5 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35858.1 - 2e-15 56.9 3.1 0.00049 20.3 0.0 5.5 3 2 2 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35858.1 - 2.3e-08 33.2 8.9 0.38 9.3 0.0 5.7 3 3 3 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO35858.1 - 6.3e-06 25.7 3.9 0.069 12.5 0.6 4.7 2 2 2 5 5 5 1 WD40-like domain DUF4221 PF13970.6 ETO35858.1 - 0.071 12.7 6.1 0.47 10.0 5.8 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) DUF1030 PF06270.11 ETO35858.1 - 0.14 11.9 1.1 1.7 8.4 0.2 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF1030) WD40 PF00400.32 ETO35859.1 - 1.8e-30 104.5 10.9 5.9e-06 26.9 0.1 7.4 7 0 0 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35859.1 - 3.8e-11 43.1 0.7 0.26 11.6 0.0 5.7 1 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35859.1 - 7.1e-08 32.1 0.9 0.0049 16.2 0.1 2.9 2 1 0 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO35859.1 - 4.9e-07 29.5 0.2 0.16 11.9 0.0 3.9 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO35859.1 - 2.6e-05 22.9 0.2 0.00076 18.1 0.0 2.4 2 1 1 3 3 3 1 Cytochrome D1 heme domain Nup160 PF11715.8 ETO35859.1 - 4.8e-05 22.2 1.1 0.15 10.6 0.0 3.4 1 1 2 3 3 3 2 Nucleoporin Nup120/160 DUF5046 PF16465.5 ETO35859.1 - 0.0067 15.9 0.0 3.7 6.9 0.0 2.2 2 0 0 2 2 2 2 Domain of unknown function (DUF5046) DUF5122 PF17164.4 ETO35859.1 - 0.027 14.7 0.1 9 6.7 0.0 3.0 3 0 0 3 3 3 0 Domain of unknown function (DUF5122) beta-propeller PQQ_2 PF13360.6 ETO35859.1 - 0.054 13.1 0.1 2.1 7.8 0.1 2.5 1 1 0 1 1 1 0 PQQ-like domain Proteasome_A_N PF10584.9 ETO35859.1 - 0.21 11.3 0.5 33 4.3 0.0 3.0 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO35860.1 - 4.6e-45 150.7 27.2 3.1e-10 40.5 0.2 7.1 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35860.1 - 3.2e-16 59.4 2.3 0.007 16.6 0.0 6.0 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35860.1 - 3e-10 39.6 0.1 0.00072 18.6 0.0 3.6 1 1 1 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35860.1 - 9e-07 28.5 0.2 0.011 15.0 0.0 4.2 2 1 1 4 4 4 2 WD40-like domain Nup160 PF11715.8 ETO35860.1 - 0.0031 16.2 7.5 0.87 8.1 0.4 4.4 2 1 2 4 4 4 2 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO35860.1 - 0.0071 15.7 0.2 0.064 12.6 0.0 2.6 2 2 1 3 3 3 1 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO35860.1 - 0.03 14.3 1.7 16 5.5 0.0 4.3 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat GYF_2 PF14237.6 ETO35861.1 - 4.2e-06 26.5 0.0 7.7e-06 25.6 0.0 1.5 1 0 0 1 1 1 1 GYF domain 2 DUF3464 PF11947.8 ETO35861.1 - 8 6.2 8.0 19 5.0 8.0 1.6 1 0 0 1 1 1 0 Photosynthesis affected mutant 68 WD40 PF00400.32 ETO35862.1 - 1e-31 108.4 15.1 1.4e-07 32.1 0.1 4.6 5 0 0 5 5 5 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO35862.1 - 2.6e-07 29.9 0.1 0.65 8.9 0.0 4.1 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO35862.1 - 5.1e-07 29.9 0.3 0.57 10.5 0.0 4.2 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35862.1 - 0.01 14.5 0.1 2.4 6.7 0.0 2.8 2 1 1 3 3 3 0 Nucleoporin Nup120/160 Mid2 PF04478.12 ETO35862.1 - 0.015 15.1 0.1 4.5 7.1 0.0 2.8 2 1 1 3 3 3 0 Mid2 like cell wall stress sensor LRR_8 PF13855.6 ETO35863.1 - 2.9e-10 39.8 35.6 2.4e-05 24.0 1.9 5.8 5 1 1 6 6 6 4 Leucine rich repeat LRR_4 PF12799.7 ETO35863.1 - 2.5e-06 27.7 46.3 0.015 15.7 2.4 7.2 4 2 3 8 8 8 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO35863.1 - 0.18 12.5 0.6 0.18 12.5 0.6 7.3 7 3 1 8 8 8 0 Leucine Rich Repeat HSP70 PF00012.20 ETO35864.1 - 2.5e-157 524.7 3.1 3.3e-157 524.3 3.1 1.1 1 0 0 1 1 1 1 Hsp70 protein MreB_Mbl PF06723.13 ETO35864.1 - 1e-12 47.6 0.3 4.5e-12 45.4 0.3 1.8 1 1 0 1 1 1 1 MreB/Mbl protein FGGY_C PF02782.16 ETO35864.1 - 0.017 14.8 0.0 0.038 13.7 0.0 1.7 1 0 0 1 1 1 0 FGGY family of carbohydrate kinases, C-terminal domain Glt_symporter PF03616.14 ETO35864.1 - 0.1 11.2 0.2 0.18 10.5 0.2 1.3 1 0 0 1 1 1 0 Sodium/glutamate symporter bZIP_1 PF00170.21 ETO35867.1 - 7e-09 35.7 8.1 2e-08 34.2 8.1 1.8 1 0 0 1 1 1 1 bZIP transcription factor bZIP_2 PF07716.15 ETO35867.1 - 1.9e-05 24.7 9.1 4.9e-05 23.3 9.1 1.7 1 0 0 1 1 1 1 Basic region leucine zipper DUF5014 PF16406.5 ETO35867.1 - 0.0044 17.3 0.6 0.11 12.8 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5014) bZIP_Maf PF03131.17 ETO35867.1 - 0.52 10.9 11.2 0.034 14.7 5.7 1.8 2 0 0 2 2 2 0 bZIP Maf transcription factor V-SNARE_C PF12352.8 ETO35868.1 - 6.9e-06 26.3 10.8 0.043 14.1 0.1 3.3 3 0 0 3 3 3 3 Snare region anchored in the vesicle membrane C-terminus DUF5089 PF17002.5 ETO35868.1 - 7.6e-05 22.7 8.0 7.6e-05 22.7 8.0 2.8 1 1 2 3 3 3 1 Domain of unknown function (DUF5089) DUF948 PF06103.11 ETO35868.1 - 0.024 14.9 8.9 4.5 7.6 2.9 3.2 2 1 1 3 3 3 0 Bacterial protein of unknown function (DUF948) MCPsignal PF00015.21 ETO35868.1 - 1.4 8.7 7.3 0.31 10.8 2.3 2.2 1 1 1 3 3 3 0 Methyl-accepting chemotaxis protein (MCP) signalling domain DUF2263 PF10021.9 ETO35869.1 - 6.7e-28 97.9 0.1 2e-13 50.9 0.0 2.4 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2263) BNR_6 PF15899.5 ETO35869.1 - 0.094 12.8 0.6 0.24 11.6 0.2 1.9 2 0 0 2 2 2 0 BNR-Asp box repeat WD40 PF00400.32 ETO35870.1 - 6.6e-08 33.1 4.4 7.6e-06 26.6 1.1 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat Nucleoporin_N PF08801.11 ETO35870.1 - 0.089 11.5 0.1 0.21 10.3 0.1 1.6 1 1 1 2 2 2 0 Nup133 N terminal like Blo-t-5 PF11642.8 ETO35871.1 - 0.11 12.4 2.8 9.9 6.2 0.0 2.2 2 0 0 2 2 2 0 Mite allergen Blo t 5 Viral_env_E26 PF11050.8 ETO35871.1 - 0.38 10.1 5.0 0.46 9.8 3.1 1.8 2 0 0 2 2 2 0 Virus envelope protein E26 Peptidase_S66 PF02016.15 ETO35872.1 - 0.17 12.0 0.0 0.67 10.1 0.0 2.0 2 0 0 2 2 2 0 LD-carboxypeptidase N-terminal domain FAM76 PF16046.5 ETO35872.1 - 5.2 6.3 16.4 10 5.4 16.4 1.4 1 0 0 1 1 1 0 FAM76 protein HYR PF02494.16 ETO35873.1 - 4.4e-26 91.0 1.7 6.1e-07 29.7 0.0 4.5 3 1 0 3 3 3 3 HYR domain DUF5011 PF16403.5 ETO35873.1 - 0.08 13.1 2.7 0.68 10.1 0.0 3.6 4 0 0 4 4 4 0 Domain of unknown function (DUF5011) ELH PF02323.15 ETO35873.1 - 0.32 10.3 8.6 0.65 9.3 8.6 1.5 1 0 0 1 1 1 0 Egg-laying hormone precursor Presenilin PF01080.17 ETO35873.1 - 0.39 9.4 10.0 0.88 8.3 10.0 1.5 1 0 0 1 1 1 0 Presenilin Methyltransf_25 PF13649.6 ETO35874.1 - 9.6e-11 42.3 0.0 2.6e-10 40.9 0.0 1.7 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO35874.1 - 1.5e-09 38.4 0.0 6.1e-09 36.4 0.0 1.9 2 0 0 2 2 2 1 Methyltransferase domain TehB PF03848.14 ETO35874.1 - 1.2e-05 24.9 0.2 1.7e-05 24.3 0.2 1.3 1 0 0 1 1 1 1 Tellurite resistance protein TehB NodS PF05401.11 ETO35874.1 - 2.4e-05 24.0 0.1 3.7e-05 23.4 0.1 1.2 1 0 0 1 1 1 1 Nodulation protein S (NodS) Methyltransf_PK PF05891.12 ETO35874.1 - 5.6e-05 22.8 0.2 8.4e-05 22.2 0.2 1.3 1 0 0 1 1 1 1 AdoMet dependent proline di-methyltransferase Phage_RpbA PF10789.9 ETO35874.1 - 0.019 15.0 0.4 0.12 12.5 0.0 2.2 2 0 0 2 2 2 0 Phage RNA polymerase binding, RpbA Methyltransf_23 PF13489.6 ETO35874.1 - 0.053 13.4 0.0 0.11 12.3 0.0 1.5 1 1 0 1 1 1 0 Methyltransferase domain ODC_AZ PF02100.17 ETO35874.1 - 0.067 13.2 0.2 1.2 9.1 0.1 2.2 2 0 0 2 2 2 0 Ornithine decarboxylase antizyme NAD_binding_4 PF07993.12 ETO35876.1 - 4.4e-53 180.1 0.0 1.1e-52 178.8 0.0 1.6 2 0 0 2 2 2 1 Male sterility protein Sterile PF03015.19 ETO35876.1 - 1.8e-10 40.9 2.2 1.8e-10 40.9 2.2 2.9 3 0 0 3 3 3 1 Male sterility protein 3Beta_HSD PF01073.19 ETO35876.1 - 2.6e-05 23.4 0.5 0.0036 16.4 0.3 3.0 2 1 0 2 2 2 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO35876.1 - 0.0038 16.7 0.0 0.033 13.6 0.0 2.2 2 0 0 2 2 2 1 NAD dependent epimerase/dehydratase family DUF2681 PF10883.8 ETO35876.1 - 0.03 14.7 5.2 0.63 10.5 3.4 2.6 2 0 0 2 2 2 0 Protein of unknown function (DUF2681) Polysacc_synt_2 PF02719.15 ETO35876.1 - 0.046 12.8 3.1 0.71 8.9 0.1 3.2 3 1 0 3 3 3 0 Polysaccharide biosynthesis protein Ldh_1_C PF02866.18 ETO35877.1 - 1.7e-15 57.4 0.0 2e-15 57.1 0.0 1.0 1 0 0 1 1 1 1 lactate/malate dehydrogenase, alpha/beta C-terminal domain NMT1_3 PF16868.5 ETO35877.1 - 0.19 11.1 0.0 0.24 10.8 0.0 1.2 1 0 0 1 1 1 0 NMT1-like family Arg_tRNA_synt_N PF03485.16 ETO35878.1 - 0.033 14.8 0.1 0.035 14.7 0.1 1.2 1 0 0 1 1 1 0 Arginyl tRNA synthetase N terminal domain Pik1 PF11522.8 ETO35878.1 - 0.33 10.9 2.6 8.3 6.5 0.2 2.6 1 1 1 2 2 2 0 Yeast phosphatidylinositol-4-OH kinase Pik1 Kelch_4 PF13418.6 ETO35879.1 - 5e-06 26.4 0.5 0.00046 20.1 0.2 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO35879.1 - 0.00023 21.0 0.1 0.23 11.5 0.0 3.6 3 0 0 3 3 3 1 Kelch motif Kelch_1 PF01344.25 ETO35879.1 - 0.00045 19.8 0.3 0.0028 17.2 0.1 2.4 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO35879.1 - 0.05 13.9 1.8 0.96 9.8 0.3 3.1 2 1 1 3 3 3 0 Kelch motif Kelch_5 PF13854.6 ETO35879.1 - 0.15 12.1 2.3 0.82 9.7 0.3 3.0 4 0 0 4 4 4 0 Kelch motif DUF4252 PF14060.6 ETO35879.1 - 0.28 11.1 2.6 2.1 8.3 0.2 2.4 1 1 1 2 2 2 0 Domain of unknown function (DUF4252) WD40 PF00400.32 ETO35880.1 - 4.7e-07 30.4 1.4 9.2e-07 29.5 0.8 1.8 2 1 0 2 2 2 1 WD domain, G-beta repeat Ig_6 PF18452.1 ETO35880.1 - 0.00091 18.7 0.1 0.0017 17.8 0.1 1.4 1 0 0 1 1 1 1 Immunoglobulin domain Nup160 PF11715.8 ETO35880.1 - 0.063 11.9 0.0 0.066 11.9 0.0 1.1 1 0 0 1 1 1 0 Nucleoporin Nup120/160 AMPK1_CBM PF16561.5 ETO35880.1 - 0.072 13.3 0.0 0.13 12.5 0.0 1.5 1 0 0 1 1 1 0 Glycogen recognition site of AMP-activated protein kinase CAP_GLY PF01302.25 ETO35882.1 - 1.3e-23 82.8 3.4 3.7e-10 39.7 0.2 4.3 3 1 0 3 3 3 3 CAP-Gly domain FSA_C PF10479.9 ETO35883.1 - 0.011 13.9 6.9 0.015 13.5 6.9 1.3 1 0 0 1 1 1 0 Fragile site-associated protein C-terminus TP6A_N PF04406.14 ETO35883.1 - 0.061 13.3 0.2 0.17 11.9 0.2 1.8 1 0 0 1 1 1 0 Type IIB DNA topoisomerase Mucin PF01456.17 ETO35883.1 - 1.9 8.5 22.8 4 7.4 22.8 1.4 1 0 0 1 1 1 0 Mucin-like glycoprotein DUF3439 PF11921.8 ETO35883.1 - 7 6.6 12.9 15 5.6 12.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) DUF3439 PF11921.8 ETO35884.1 - 0.94 9.4 7.5 2.5 8.1 7.5 1.7 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) Kelch_6 PF13964.6 ETO35886.1 - 6.6e-06 26.2 1.6 0.062 13.6 0.0 3.5 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO35886.1 - 1.9e-05 24.1 0.9 0.0048 16.4 0.6 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO35886.1 - 0.00023 21.1 0.0 0.047 13.7 0.0 2.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO35886.1 - 0.0099 16.1 0.0 1.4 9.3 0.0 2.7 2 0 0 2 2 2 1 Galactose oxidase, central domain RBD-FIP PF09457.10 ETO35886.1 - 0.14 12.1 0.3 0.28 11.1 0.3 1.5 1 0 0 1 1 1 0 FIP domain DUF1138 PF06592.13 ETO35886.1 - 0.21 11.7 0.3 5.1 7.2 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1138) U-box PF04564.15 ETO35887.1 - 3.6e-13 49.5 0.0 1.3e-12 47.7 0.0 2.0 1 0 0 1 1 1 1 U-box domain MbeD_MobD PF04899.12 ETO35887.1 - 0.0004 20.4 0.9 0.0012 19.0 0.9 1.8 1 0 0 1 1 1 1 MbeD/MobD like zf-NOSIP PF15906.5 ETO35887.1 - 0.011 15.8 0.1 0.022 14.9 0.1 1.5 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein ProQ PF04352.13 ETO35887.1 - 0.018 14.9 0.2 0.044 13.7 0.2 1.6 1 0 0 1 1 1 0 ProQ/FINO family DUF4200 PF13863.6 ETO35887.1 - 0.042 14.2 15.6 0.089 13.2 15.6 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) P22_Tail-4 PF11650.8 ETO35887.1 - 0.096 12.6 0.0 0.21 11.6 0.0 1.5 1 1 0 1 1 1 0 P22 tail accessory factor CR6_interact PF10147.9 ETO35887.1 - 0.11 12.2 6.7 0.21 11.3 6.7 1.4 1 0 0 1 1 1 0 Growth arrest and DNA-damage-inducible proteins-interacting protein 1 MscS_porin PF12795.7 ETO35887.1 - 0.44 10.1 7.6 0.69 9.4 7.6 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel porin domain DUF737 PF05300.11 ETO35887.1 - 1.5 9.2 11.9 2.3 8.5 11.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF737) TPR_MLP1_2 PF07926.12 ETO35887.1 - 2 8.5 17.9 2.3 8.3 5.8 2.5 2 0 0 2 2 2 0 TPR/MLP1/MLP2-like protein KapB PF08810.10 ETO35887.1 - 2.7 8.2 7.5 17 5.6 2.8 2.6 1 1 1 2 2 2 0 Kinase associated protein B GIT1_C PF12205.8 ETO35887.1 - 2.7 8.1 7.0 8.7 6.5 5.7 2.5 2 1 0 2 2 2 0 G protein-coupled receptor kinase-interacting protein 1 C term Phage_GPO PF05929.11 ETO35887.1 - 2.8 7.5 7.3 4.9 6.7 7.3 1.3 1 0 0 1 1 1 0 Phage capsid scaffolding protein (GPO) serine peptidase Swi5 PF07061.11 ETO35887.1 - 5.9 7.1 9.9 41 4.4 6.8 3.2 2 1 0 2 2 2 0 Swi5 LMBR1 PF04791.16 ETO35887.1 - 7 5.4 6.0 8.5 5.2 6.0 1.3 1 0 0 1 1 1 0 LMBR1-like membrane protein XK-related PF09815.9 ETO35888.1 - 0.00025 20.2 0.6 0.00051 19.2 0.6 1.4 1 0 0 1 1 1 1 XK-related protein Androgen_recep PF02166.16 ETO35888.1 - 0.65 8.8 1.5 0.86 8.4 1.5 1.1 1 0 0 1 1 1 0 Androgen receptor Syntaxin_2 PF14523.6 ETO35889.1 - 0.0018 18.6 5.1 0.024 15.0 5.1 2.4 1 1 0 1 1 1 1 Syntaxin-like protein Dna2 PF08696.11 ETO35889.1 - 0.56 10.0 6.6 0.63 9.8 5.7 1.4 1 1 0 1 1 1 0 DNA replication factor Dna2 DUF2400 PF09674.10 ETO35889.1 - 0.56 10.2 5.2 0.66 9.9 5.2 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2400) DUF4473 PF14747.6 ETO35889.1 - 2.9 8.5 7.8 0.39 11.3 0.9 2.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4473) U-box PF04564.15 ETO35890.1 - 4.6e-12 45.9 0.0 2.6e-11 43.5 0.0 2.5 1 0 0 1 1 1 1 U-box domain Kelch_6 PF13964.6 ETO35890.1 - 0.063 13.6 5.0 11 6.4 0.0 4.1 4 1 1 5 5 5 0 Kelch motif Kelch_1 PF01344.25 ETO35890.1 - 0.098 12.3 0.8 4.8 6.8 0.2 3.1 3 0 0 3 3 3 0 Kelch motif WD40 PF00400.32 ETO35891.1 - 5.3e-12 46.1 8.0 6.2e-05 23.7 1.1 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35891.1 - 6.9e-06 25.0 1.4 0.00062 18.5 0.3 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35891.1 - 0.087 13.1 0.1 17 5.8 0.1 2.3 1 1 1 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain WYL_2 PF10902.8 ETO35891.1 - 0.11 12.8 0.2 0.99 9.8 0.1 2.1 2 0 0 2 2 2 0 WYL_2, Sm-like SH3 beta-barrel fold Dicty_REP PF05086.12 ETO35892.1 - 0.18 9.7 10.6 0.2 9.6 10.6 1.1 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein PH_12 PF16457.5 ETO35892.1 - 2.3 8.8 8.0 9 6.8 8.0 2.0 1 1 0 1 1 1 0 Pleckstrin homology domain Mg_trans_NIPA PF05653.14 ETO35893.1 - 3.4e-05 23.1 0.4 0.0054 15.9 0.0 2.1 2 0 0 2 2 2 2 Magnesium transporter NIPA DUF3671 PF12420.8 ETO35893.1 - 0.0081 16.2 0.1 0.026 14.6 0.1 1.8 1 0 0 1 1 1 1 Protein of unknown function FlgN PF05130.12 ETO35895.1 - 0.034 14.6 0.8 0.11 13.1 0.8 1.8 1 1 0 1 1 1 0 FlgN protein bZIP_1 PF00170.21 ETO35895.1 - 0.3 11.2 4.4 8.7 6.5 1.2 2.5 2 0 0 2 2 2 0 bZIP transcription factor DUF5625 PF18539.1 ETO35896.1 - 0.00057 20.2 1.5 0.00085 19.6 0.1 1.8 1 1 1 2 2 2 1 Domain of unknown function (DUF5625) Nmad5 PF18757.1 ETO35896.1 - 0.014 15.7 7.6 0.021 15.0 7.6 1.3 1 0 0 1 1 1 0 Nucleotide modification associated domain 5 XhlA PF10779.9 ETO35896.1 - 0.043 14.0 7.9 0.043 14.0 7.9 2.6 1 1 0 2 2 2 0 Haemolysin XhlA HsbA PF12296.8 ETO35896.1 - 0.072 13.5 2.4 0.11 12.9 2.4 1.2 1 0 0 1 1 1 0 Hydrophobic surface binding protein A DUF2935 PF11155.8 ETO35896.1 - 0.075 13.4 5.9 0.13 12.6 5.9 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF2935) Exonuc_VII_L PF02601.15 ETO35896.1 - 0.18 11.3 11.1 0.2 11.2 11.1 1.2 1 0 0 1 1 1 0 Exonuclease VII, large subunit AKNA PF12443.8 ETO35896.1 - 0.3 11.7 13.3 0.35 11.6 1.3 2.6 1 1 1 2 2 2 0 AT-hook-containing transcription factor Phage_GPO PF05929.11 ETO35896.1 - 0.44 10.1 14.2 0.012 15.2 8.3 1.3 2 0 0 2 2 2 0 Phage capsid scaffolding protein (GPO) serine peptidase NPV_P10 PF05531.12 ETO35896.1 - 0.47 11.0 12.5 13 6.3 11.0 2.9 2 1 0 2 2 2 0 Nucleopolyhedrovirus P10 protein FAM76 PF16046.5 ETO35896.1 - 0.48 9.7 21.6 0.23 10.8 19.4 1.6 1 1 0 1 1 1 0 FAM76 protein LMBR1 PF04791.16 ETO35896.1 - 1 8.2 12.8 1.2 8.0 12.8 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein DUF948 PF06103.11 ETO35896.1 - 1.1 9.5 6.3 0.64 10.3 3.7 1.9 1 1 2 3 3 3 0 Bacterial protein of unknown function (DUF948) DUF3573 PF12097.8 ETO35896.1 - 4.4 6.0 8.8 6.9 5.4 8.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) CENP-Q PF13094.6 ETO35896.1 - 5.3 7.2 18.4 5.2 7.2 10.3 2.2 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit DUF724 PF05266.14 ETO35896.1 - 5.7 6.7 20.3 1e+02 2.7 8.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF724) ALMT PF11744.8 ETO35896.1 - 5.8 5.6 12.6 7.8 5.2 12.6 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter TPR_12 PF13424.6 ETO35897.1 - 1.1e-72 240.3 26.1 1.1e-20 73.7 0.1 5.6 2 1 3 6 6 6 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35897.1 - 5.3e-60 197.8 13.1 5.1e-09 35.7 0.0 8.1 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35897.1 - 3.2e-51 169.1 56.6 2.2e-08 33.6 1.7 8.1 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35897.1 - 1.1e-38 128.2 42.3 1.6e-06 27.8 0.7 8.2 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35897.1 - 1.3e-37 125.1 11.9 0.00017 21.4 0.0 8.2 8 0 0 8 8 8 7 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35897.1 - 9.6e-31 103.4 48.2 7e-06 25.8 1.2 8.2 8 0 0 8 8 8 8 Tetratricopeptide repeat TPR_16 PF13432.6 ETO35897.1 - 2.6e-19 69.6 0.2 0.0001 22.9 0.1 5.8 5 2 1 6 6 6 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35897.1 - 8.5e-18 63.7 9.4 0.18 12.5 0.1 8.3 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35897.1 - 1.2e-17 62.9 29.7 0.0013 18.9 0.5 8.1 7 3 0 7 7 7 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35897.1 - 1.7e-16 59.6 60.4 0.00026 20.6 4.8 11.6 7 5 6 13 13 12 8 TPR repeat TPR_14 PF13428.6 ETO35897.1 - 3.8e-16 58.4 0.0 1.9 9.5 0.0 8.0 6 1 2 8 8 8 1 Tetratricopeptide repeat SNAP PF14938.6 ETO35897.1 - 7.5e-14 51.8 20.1 1.3e-07 31.3 5.7 3.6 1 1 2 3 3 3 3 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO35897.1 - 1.4e-11 44.3 31.2 0.019 15.0 0.4 7.4 7 1 1 8 8 7 4 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO35897.1 - 9.3e-11 41.0 0.1 1.7 8.1 0.0 6.8 7 0 0 7 7 7 2 SHNi-TPR DUF2225 PF09986.9 ETO35897.1 - 2.5e-09 37.2 24.7 0.00034 20.4 1.2 4.2 1 1 3 4 4 4 3 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 ETO35897.1 - 5.2e-09 36.5 3.0 0.031 14.8 0.1 5.4 5 0 0 5 5 5 1 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO35897.1 - 2.2e-07 31.0 20.8 0.015 15.5 1.0 5.4 4 2 1 5 5 5 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_5 PF12688.7 ETO35897.1 - 3.8e-07 30.4 0.4 0.047 13.9 0.1 4.5 3 2 2 5 5 5 2 Tetratrico peptide repeat DUF5113 PF17140.4 ETO35897.1 - 1.7e-06 27.9 30.4 0.17 11.7 0.5 6.7 7 0 0 7 7 7 3 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETO35897.1 - 1.7e-05 24.6 13.8 0.0013 18.5 4.5 4.2 1 1 1 3 3 3 1 26S proteasome subunit RPN7 TPR_MalT PF17874.1 ETO35897.1 - 7.4e-05 22.3 0.0 0.029 13.8 0.0 3.1 1 1 3 4 4 4 2 MalT-like TPR region Rota_NSP3 PF01665.16 ETO35897.1 - 0.00078 18.7 4.1 0.0045 16.2 0.1 2.4 2 0 0 2 2 2 1 Rotavirus non-structural protein NSP3 TPR_15 PF13429.6 ETO35897.1 - 0.0048 16.2 0.4 1 8.5 0.0 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_3 PF07720.12 ETO35897.1 - 0.0084 16.1 4.4 0.099 12.7 0.3 6.2 7 0 0 7 7 5 3 Tetratricopeptide repeat PPR PF01535.20 ETO35897.1 - 0.014 15.6 8.4 23 5.5 0.0 6.2 8 0 0 8 8 5 0 PPR repeat SMBP PF16785.5 ETO35897.1 - 0.022 15.0 4.1 22 5.3 0.0 4.8 4 2 1 5 5 5 0 Small metal-binding protein DUF3856 PF12968.7 ETO35897.1 - 0.025 14.7 5.4 0.44 10.6 0.1 3.5 3 2 1 4 4 4 0 Domain of Unknown Function (DUF3856) Sel1 PF08238.12 ETO35897.1 - 0.033 14.9 25.0 1 10.1 0.1 7.7 9 1 0 9 9 8 0 Sel1 repeat DUF627 PF04781.12 ETO35897.1 - 0.04 13.9 5.6 4.8 7.3 0.5 4.1 2 2 1 3 3 3 0 Protein of unknown function (DUF627) ATP-synt_E_2 PF08112.11 ETO35897.1 - 0.06 13.6 1.4 39 4.6 0.2 4.1 4 0 0 4 4 4 0 ATP synthase epsilon subunit OEP PF02321.18 ETO35897.1 - 0.15 11.9 12.6 3.8 7.3 7.9 3.0 2 1 0 2 2 2 0 Outer membrane efflux protein Rapsyn_N PF10579.9 ETO35897.1 - 0.43 10.7 2.7 74 3.5 0.0 4.2 4 1 1 5 5 3 0 Rapsyn N-terminal myristoylation and linker region HTH_Bact PF18768.1 ETO35897.1 - 2.3 7.8 15.5 18 5.0 0.1 6.3 7 0 0 7 7 7 0 Helix-turn-helix bacterial domain Mob_Pre PF01076.19 ETO35897.1 - 8.9 6.1 13.3 2.3 8.0 4.6 3.0 2 1 1 3 3 3 0 Plasmid recombination enzyme TPR_12 PF13424.6 ETO35898.1 - 5.2e-38 129.2 3.2 1.1e-16 60.9 0.0 3.4 2 2 1 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35898.1 - 2.9e-24 84.2 1.5 5.5e-05 22.9 0.0 4.8 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35898.1 - 4e-20 70.7 22.5 8.1e-07 28.6 0.6 4.9 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35898.1 - 4.5e-19 67.0 11.7 5.3e-06 26.2 0.1 4.8 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35898.1 - 4.1e-18 64.0 19.7 0.00012 22.0 0.4 5.2 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35898.1 - 6.5e-17 60.2 2.9 2.3e-05 24.1 0.2 4.6 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35898.1 - 6.1e-09 35.4 12.9 0.03 14.0 0.5 5.2 5 0 0 5 5 5 3 TPR repeat TPR_16 PF13432.6 ETO35898.1 - 9.4e-08 32.6 0.0 0.02 15.5 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35898.1 - 7.6e-06 26.2 0.8 0.24 12.1 0.0 4.4 4 0 0 4 4 4 1 Tetratricopeptide repeat DUF2225 PF09986.9 ETO35898.1 - 2.9e-05 23.9 4.4 0.00014 21.7 1.3 2.4 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2225) TPR_17 PF13431.6 ETO35898.1 - 4.6e-05 23.5 12.7 0.28 11.7 0.0 4.9 6 0 0 6 6 4 3 Tetratricopeptide repeat MIT PF04212.18 ETO35898.1 - 0.00017 21.6 10.2 0.27 11.3 0.2 4.0 3 1 0 3 3 3 2 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO35898.1 - 0.00038 21.0 0.0 3 8.9 0.0 3.9 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO35898.1 - 0.0007 19.1 0.1 0.098 12.0 0.1 2.1 2 0 0 2 2 2 1 MalT-like TPR region DUF627 PF04781.12 ETO35898.1 - 0.0021 18.1 0.9 10 6.2 0.0 4.3 3 1 1 4 4 4 0 Protein of unknown function (DUF627) SNAP PF14938.6 ETO35898.1 - 0.0033 16.9 3.0 0.028 13.9 2.8 2.2 1 1 1 2 2 2 2 Soluble NSF attachment protein, SNAP HTH_Bact PF18768.1 ETO35898.1 - 0.037 13.6 2.9 4.4 7.0 0.1 3.7 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain PPR PF01535.20 ETO35898.1 - 0.045 14.0 8.5 0.098 13.0 0.1 4.5 5 0 0 5 5 4 0 PPR repeat ANAPC3 PF12895.7 ETO35898.1 - 1.1 9.5 8.4 3 8.2 0.3 3.8 1 1 3 4 4 4 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_12 PF13424.6 ETO35900.1 - 1.6e-41 140.4 13.8 2.3e-14 53.4 0.9 3.1 1 1 3 4 4 4 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35900.1 - 6.5e-18 63.4 5.1 9.6e-05 22.2 0.1 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35900.1 - 8.1e-16 57.3 0.7 0.0021 17.8 0.1 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35900.1 - 4.7e-14 51.5 21.4 1.2e-05 25.0 1.1 4.9 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35900.1 - 1.6e-10 40.3 16.7 0.011 15.8 0.3 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35900.1 - 2.8e-09 36.4 17.8 0.0044 17.1 0.6 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO35900.1 - 0.003 18.2 0.0 3.8 8.6 0.0 3.4 4 0 0 4 4 3 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO35900.1 - 0.011 16.3 2.7 86 4.1 0.1 4.4 4 0 0 4 4 4 0 Tetratricopeptide repeat zf-UBP PF02148.19 ETO35900.1 - 0.017 15.4 1.5 0.054 13.8 0.7 2.2 2 0 0 2 2 2 0 Zn-finger in ubiquitin-hydrolases and other protein TPR_17 PF13431.6 ETO35900.1 - 0.068 13.6 1.9 8.8 7.0 0.1 3.6 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO35900.1 - 0.073 12.9 11.0 2.8 7.7 0.4 4.2 2 2 2 4 4 4 0 Domain of unknown function (DUF5113) MIT PF04212.18 ETO35900.1 - 0.13 12.3 9.4 7.4 6.7 0.5 4.2 4 0 0 4 4 4 0 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO35900.1 - 0.43 10.1 2.2 3.3 7.2 0.1 3.0 3 0 0 3 3 3 0 SHNi-TPR TPR_3 PF07720.12 ETO35900.1 - 2.5 8.2 6.3 4.7 7.3 0.5 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35900.1 - 4.9 6.9 16.3 7.6 6.3 0.2 4.8 4 1 1 5 5 5 0 TPR repeat Kelch_6 PF13964.6 ETO35901.1 - 7.6e-10 38.7 1.8 0.00013 22.1 0.0 4.3 3 1 1 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO35901.1 - 1.1e-05 25.2 0.9 0.009 16.0 0.0 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO35901.1 - 1.5e-05 24.9 0.0 0.00061 19.7 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO35901.1 - 0.00018 21.0 0.7 0.38 10.4 0.0 3.6 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO35901.1 - 0.001 19.0 6.0 0.16 12.0 0.1 4.2 6 0 0 6 6 6 2 Kelch motif Kelch_3 PF13415.6 ETO35901.1 - 0.0028 17.9 0.1 0.042 14.1 0.0 3.1 5 0 0 5 5 5 1 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO35901.1 - 0.057 12.6 0.4 0.9 8.6 0.1 2.2 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase DUF3674 PF12426.8 ETO35902.1 - 0.13 12.3 0.0 0.25 11.4 0.0 1.4 1 0 0 1 1 1 0 RNA dependent RNA polymerase WD40 PF00400.32 ETO35903.1 - 2.2e-13 50.4 15.8 0.001 19.8 0.6 6.3 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35903.1 - 0.0019 18.4 0.6 11 6.4 0.0 3.8 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Pacifastin_I PF05375.13 ETO35903.1 - 1.5 8.6 7.6 0.066 12.9 1.5 1.9 2 0 0 2 2 2 0 Pacifastin inhibitor (LCMII) Pkinase PF00069.25 ETO35905.1 - 2.5e-57 194.2 0.0 1.6e-56 191.6 0.0 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35905.1 - 3.2e-21 75.8 0.0 1.9e-13 50.3 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase cNMP_binding PF00027.29 ETO35905.1 - 2.4e-07 30.7 0.0 8.1e-05 22.6 0.0 2.7 2 0 0 2 2 2 2 Cyclic nucleotide-binding domain CDC45 PF02724.14 ETO35905.1 - 4.5 5.5 8.8 9.4 4.4 8.8 1.4 1 0 0 1 1 1 0 CDC45-like protein IL32 PF15225.6 ETO35908.1 - 0.12 12.7 0.0 0.12 12.7 0.0 1.6 2 0 0 2 2 2 0 Interleukin 32 zf-MYST PF17772.1 ETO35909.1 - 0.021 14.4 0.1 0.17 11.5 0.1 2.2 2 0 0 2 2 2 0 MYST family zinc finger domain WD40 PF00400.32 ETO35910.1 - 2.6e-27 94.5 21.0 8.1e-07 29.6 1.4 6.2 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO35910.1 - 3.5e-08 32.6 5.9 0.88 8.1 0.1 5.0 2 2 3 5 5 5 5 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35910.1 - 5.1e-08 33.1 0.4 1.5 9.2 0.0 5.2 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Kelch_6 PF13964.6 ETO35911.1 - 1.3e-05 25.3 1.2 1.2 9.5 0.1 3.6 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO35911.1 - 1.4e-05 24.9 1.0 1.2 9.1 0.3 4.2 5 0 0 5 5 5 3 Kelch motif Kelch_3 PF13415.6 ETO35911.1 - 0.0011 19.2 1.2 0.0076 16.5 0.3 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO35911.1 - 0.0014 18.5 4.6 0.36 10.9 0.2 4.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO35911.1 - 0.0035 16.9 0.5 0.33 10.6 0.1 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO35911.1 - 0.029 14.4 0.4 1.8 8.6 0.3 2.8 2 0 0 2 2 2 0 Galactose oxidase, central domain N_Asn_amidohyd PF14736.6 ETO35911.1 - 0.049 12.8 0.2 0.62 9.2 0.2 2.1 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase Macoilin PF09726.9 ETO35912.1 - 0.015 13.9 7.1 0.017 13.7 7.1 1.1 1 0 0 1 1 1 0 Macoilin family OmpH PF03938.14 ETO35912.1 - 0.11 12.9 14.1 0.14 12.5 14.1 1.1 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) LMBR1 PF04791.16 ETO35912.1 - 4.9 5.9 8.3 5.3 5.8 8.3 1.0 1 0 0 1 1 1 0 LMBR1-like membrane protein RlaP PF10127.9 ETO35913.1 - 2.2e-18 66.7 0.0 3.6e-18 66.1 0.0 1.3 1 0 0 1 1 1 1 RNA repair pathway DNA polymerase beta family ERCC4 PF02732.15 ETO35913.1 - 0.084 13.1 1.2 0.21 11.8 0.4 2.0 2 0 0 2 2 2 0 ERCC4 domain DUF3844 PF12955.7 ETO35914.1 - 0.0025 17.9 0.0 0.0045 17.1 0.0 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF3844) N_methyl PF07963.12 ETO35915.1 - 1.1e-05 24.8 3.9 2.7e-05 23.5 3.9 1.7 1 0 0 1 1 1 1 Prokaryotic N-terminal methylation motif Cortex-I_coil PF09304.10 ETO35917.1 - 0.012 15.9 0.3 0.016 15.4 0.3 1.2 1 0 0 1 1 1 0 Cortexillin I, coiled coil BTB PF00651.31 ETO35918.1 - 3.9e-06 27.0 0.1 1.1e-05 25.6 0.1 1.7 1 0 0 1 1 1 1 BTB/POZ domain BACK PF07707.15 ETO35918.1 - 0.0028 17.7 0.3 0.036 14.2 0.1 2.5 2 0 0 2 2 2 1 BTB And C-terminal Kelch DUF2683 PF10884.8 ETO35919.1 - 0.011 15.9 0.0 0.029 14.6 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2683) Cortexin PF11057.8 ETO35919.1 - 0.051 13.4 0.1 0.12 12.2 0.1 1.6 1 0 0 1 1 1 0 Cortexin of kidney Ctr PF04145.15 ETO35920.1 - 0.0024 18.5 0.6 0.059 14.0 0.6 2.5 1 1 0 1 1 1 1 Ctr copper transporter family Zip PF02535.22 ETO35920.1 - 0.031 13.5 12.1 0.057 12.6 12.1 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter CDC45 PF02724.14 ETO35920.1 - 0.032 12.5 13.7 0.042 12.2 13.7 1.1 1 0 0 1 1 1 0 CDC45-like protein Ndc1_Nup PF09531.10 ETO35920.1 - 0.061 12.0 5.2 0.068 11.9 5.2 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup PPP4R2 PF09184.11 ETO35920.1 - 0.42 10.2 25.0 0.016 14.8 19.4 1.4 2 0 0 2 2 2 0 PPP4R2 DUF4746 PF15928.5 ETO35920.1 - 1.1 8.6 15.7 0.22 10.9 12.3 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4746) DUF5427 PF10310.9 ETO35920.1 - 1.5 7.7 20.1 2.4 7.0 20.1 1.3 1 0 0 1 1 1 0 Family of unknown function (DUF5427) TP53IP5 PF15331.6 ETO35920.1 - 2.2 8.4 15.3 0.26 11.4 10.8 1.7 2 0 0 2 2 2 0 Cellular tumour antigen p53-inducible 5 GvpL_GvpF PF06386.11 ETO35920.1 - 2.4 8.0 8.1 3.7 7.4 8.1 1.2 1 0 0 1 1 1 0 Gas vesicle synthesis protein GvpL/GvpF SprA-related PF12118.8 ETO35920.1 - 3.7 6.6 20.0 5.8 6.0 20.0 1.2 1 0 0 1 1 1 0 SprA-related family Chi-conotoxin PF16981.5 ETO35920.1 - 4.4 7.6 6.7 6.8 7.0 3.1 2.5 2 0 0 2 2 2 0 chi-Conotoxin or t superfamily DUF4407 PF14362.6 ETO35920.1 - 7.9 5.7 9.6 12 5.2 9.6 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) CobT PF06213.12 ETO35920.1 - 8.2 5.7 17.7 12 5.2 17.7 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Mem_trans PF03547.18 ETO35920.1 - 9 4.6 6.3 13 4.0 6.3 1.4 1 0 0 1 1 1 0 Membrane transport protein TPR_12 PF13424.6 ETO35921.1 - 4e-35 119.9 1.3 7.8e-20 71.0 0.0 3.1 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35921.1 - 5.3e-26 89.7 0.9 3.5e-12 45.8 0.0 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO35921.1 - 1.1e-21 75.2 3.3 4.8e-09 35.6 0.0 3.8 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35921.1 - 2.3e-19 68.3 15.3 2.7e-09 36.5 0.5 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35921.1 - 5.7e-15 54.2 9.7 3.5e-05 23.6 0.1 4.2 3 1 1 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35921.1 - 2e-14 52.5 15.6 6.2e-07 29.1 0.5 4.1 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO35921.1 - 1.9e-09 38.0 0.0 0.0042 17.7 0.0 3.5 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO35921.1 - 2e-08 34.0 2.5 0.00037 20.7 1.2 3.3 2 1 0 2 2 2 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO35921.1 - 1.4e-06 28.1 8.2 0.024 14.6 0.1 4.2 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO35921.1 - 0.00087 18.8 0.0 0.0011 18.5 0.0 1.1 1 0 0 1 1 1 1 MalT-like TPR region TPR_11 PF13414.6 ETO35921.1 - 0.0009 18.9 19.9 0.11 12.2 0.2 5.7 3 3 2 6 6 6 2 TPR repeat TPR_6 PF13174.6 ETO35921.1 - 0.0014 19.2 0.6 15 6.4 0.3 3.9 3 1 1 4 4 4 0 Tetratricopeptide repeat PPR PF01535.20 ETO35921.1 - 0.0017 18.5 3.0 5.1 7.6 0.1 4.3 4 0 0 4 4 4 1 PPR repeat TPR_19 PF14559.6 ETO35921.1 - 0.002 18.6 0.4 0.49 10.9 0.1 3.1 1 1 2 3 3 3 1 Tetratricopeptide repeat SNAP PF14938.6 ETO35921.1 - 0.0023 17.4 0.8 0.0039 16.7 0.8 1.3 1 1 0 1 1 1 1 Soluble NSF attachment protein, SNAP RPN7 PF10602.9 ETO35921.1 - 0.0026 17.5 0.9 0.87 9.3 0.4 2.4 1 1 1 2 2 2 2 26S proteasome subunit RPN7 DUF5113 PF17140.4 ETO35921.1 - 0.0058 16.4 4.4 0.46 10.3 0.1 3.1 3 0 0 3 3 3 1 Domain of unknown function (DUF5113) ANAPC3 PF12895.7 ETO35921.1 - 0.023 14.9 3.8 1.5 9.1 0.4 3.1 1 1 2 3 3 3 0 Anaphase-promoting complex, cyclosome, subunit 3 TPR_14 PF13428.6 ETO35921.1 - 0.03 15.1 0.1 45 5.2 0.0 3.7 2 2 2 4 4 4 0 Tetratricopeptide repeat Sel1 PF08238.12 ETO35921.1 - 0.066 13.9 3.7 42 5.0 0.0 4.1 4 1 0 4 4 4 0 Sel1 repeat MIT PF04212.18 ETO35921.1 - 0.1 12.7 10.6 0.32 11.1 1.2 3.2 3 0 0 3 3 3 0 MIT (microtubule interacting and transport) domain TPR_12 PF13424.6 ETO35922.1 - 3.7e-07 30.3 0.0 2.4e-05 24.5 0.0 1.8 1 1 1 2 2 2 2 Tetratricopeptide repeat TPR_21 PF09976.9 ETO35922.1 - 0.0069 16.1 0.1 0.0079 15.9 0.1 1.1 1 0 0 1 1 1 1 Tetratricopeptide repeat-like domain TPR_1 PF00515.28 ETO35922.1 - 0.02 14.7 1.2 0.031 14.1 0.2 1.9 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35922.1 - 0.022 14.8 0.1 0.052 13.7 0.0 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_10 PF13374.6 ETO35922.1 - 0.025 14.4 0.0 0.84 9.6 0.0 2.1 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35922.1 - 0.034 14.4 0.3 0.034 14.4 0.3 1.7 2 0 0 2 2 2 0 Tetratricopeptide repeat CpxA_peri PF16527.5 ETO35923.1 - 0.074 13.4 0.2 0.074 13.4 0.2 1.8 2 0 0 2 2 2 0 Two-component sensor protein CpxA, periplasmic domain RNase_H PF00075.24 ETO35924.1 - 0.022 14.9 0.0 0.041 14.1 0.0 1.4 1 0 0 1 1 1 0 RNase H AbbA_antirepres PF14156.6 ETO35925.1 - 0.072 13.0 6.1 0.16 11.9 2.6 2.8 3 0 0 3 3 3 0 Antirepressor AbbA Frataxin_Cyay PF01491.16 ETO35926.1 - 2.4e-21 75.9 1.7 4.5e-21 75.0 1.7 1.5 1 1 0 1 1 1 1 Frataxin-like domain Sm_multidrug_ex PF06695.11 ETO35927.1 - 0.07 13.8 2.5 0.079 13.6 2.5 1.1 1 0 0 1 1 1 0 Putative small multi-drug export protein Bclt PF15318.6 ETO35927.1 - 2.1 8.2 5.4 2.6 7.8 5.4 1.0 1 0 0 1 1 1 0 Putative Bcl-2 like protein of testis RRM_1 PF00076.22 ETO35929.1 - 2.2e-18 65.9 0.0 3.2e-18 65.3 0.0 1.3 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RNA_bind PF08675.11 ETO35929.1 - 0.082 12.9 0.0 0.17 12.0 0.0 1.4 1 0 0 1 1 1 0 RNA binding domain ILVD_EDD PF00920.21 ETO35930.1 - 1.6e-38 132.7 0.0 2.4e-36 125.4 0.0 2.1 1 1 0 1 1 1 1 Dehydratase family ILVD_EDD PF00920.21 ETO35931.1 - 2.6e-113 379.4 0.0 3e-113 379.2 0.0 1.0 1 0 0 1 1 1 1 Dehydratase family RsbU_N PF08673.10 ETO35931.1 - 0.02 15.0 0.0 0.047 13.8 0.0 1.6 1 0 0 1 1 1 0 Phosphoserine phosphatase RsbU, N-terminal domain rve PF00665.26 ETO35932.1 - 2.4e-17 63.2 0.0 5.8e-17 62.0 0.0 1.6 2 0 0 2 2 2 1 Integrase core domain Integrase_H2C2 PF17921.1 ETO35932.1 - 1.4e-08 34.7 1.6 7.3e-08 32.4 0.3 2.2 2 0 0 2 2 2 1 Integrase zinc binding domain rve_3 PF13683.6 ETO35932.1 - 0.0047 16.7 0.0 0.0085 15.8 0.0 1.4 1 0 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 ETO35933.1 - 1.8e-17 63.6 0.4 6.5e-16 58.5 0.1 2.3 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) DUF406 PF04175.12 ETO35933.1 - 0.018 15.5 0.1 0.043 14.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF406) CENP-F_N PF10481.9 ETO35933.1 - 0.018 14.7 7.2 0.59 9.7 0.6 2.1 1 1 1 2 2 2 0 Cenp-F N-terminal domain Duffy_binding PF05424.11 ETO35933.1 - 2.8 7.9 8.4 6.8 6.7 3.6 2.4 2 1 0 2 2 2 0 Duffy binding domain RRN3 PF05327.11 ETO35934.1 - 2.1 6.8 10.4 4.6 5.7 10.4 1.6 1 1 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 JAB PF01398.21 ETO35936.1 - 4.9 7.2 5.4 0.96 9.4 0.9 2.3 2 0 0 2 2 2 0 JAB1/Mov34/MPN/PAD-1 ubiquitin protease PHC2_SAM_assoc PF16616.5 ETO35937.1 - 0.19 12.5 0.5 0.31 11.8 0.5 1.3 1 0 0 1 1 1 0 Unstructured region on Polyhomeotic-like protein 1 and 2 F5_F8_type_C PF00754.25 ETO35938.1 - 2e-07 31.2 3.7 0.0013 18.8 0.7 2.6 2 0 0 2 2 2 2 F5/8 type C domain Sad1_UNC PF07738.13 ETO35938.1 - 9.5e-06 25.7 0.9 0.035 14.1 0.2 2.3 2 0 0 2 2 2 2 Sad1 / UNC-like C-terminal RsfS PF02410.15 ETO35938.1 - 0.098 13.1 0.9 12 6.4 0.0 3.4 3 0 0 3 3 3 0 Ribosomal silencing factor during starvation Stn1_C PF12659.7 ETO35938.1 - 0.14 12.1 0.3 6.8 6.7 0.1 2.4 2 0 0 2 2 2 0 Telomere capping C-terminal wHTH DUF2399 PF09664.10 ETO35938.1 - 0.16 11.9 0.0 0.26 11.2 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) F5_F8_type_C PF00754.25 ETO35939.1 - 1.6e-07 31.4 1.8 0.00021 21.4 0.4 2.3 2 0 0 2 2 2 2 F5/8 type C domain zf-RING_11 PF17123.5 ETO35939.1 - 1.1e-06 28.3 2.9 5.8e-06 25.9 2.9 2.4 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_2 PF13639.6 ETO35939.1 - 2.4e-06 27.8 3.2 2.4e-06 27.8 3.2 6.0 7 2 0 7 7 7 1 Ring finger domain zf-rbx1 PF12678.7 ETO35939.1 - 5.2e-05 23.5 2.4 5.2e-05 23.5 2.4 4.8 5 1 0 5 5 5 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETO35939.1 - 0.00037 20.4 2.5 0.00037 20.4 2.5 5.0 5 1 0 5 5 5 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETO35939.1 - 0.0004 20.2 1.2 0.0004 20.2 1.2 5.2 6 0 0 6 6 6 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO35939.1 - 0.003 17.4 6.1 0.003 17.4 6.1 5.4 7 1 0 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-RING_UBOX PF13445.6 ETO35939.1 - 0.0067 16.4 0.6 0.0067 16.4 0.6 4.4 3 0 0 3 3 3 1 RING-type zinc-finger DUF2457 PF10446.9 ETO35940.1 - 9.7e-05 21.7 24.0 0.00011 21.5 24.0 1.2 1 0 0 1 1 1 1 Protein of unknown function (DUF2457) CDC45 PF02724.14 ETO35940.1 - 0.00093 17.6 17.7 0.001 17.5 17.7 1.1 1 0 0 1 1 1 1 CDC45-like protein RRN3 PF05327.11 ETO35940.1 - 0.0015 17.2 9.0 0.0015 17.2 9.0 1.2 1 0 0 1 1 1 1 RNA polymerase I specific transcription initiation factor RRN3 YL1 PF05764.13 ETO35940.1 - 0.0028 17.8 15.3 0.0035 17.5 15.3 1.2 1 0 0 1 1 1 1 YL1 nuclear protein CDC27 PF09507.10 ETO35940.1 - 0.0039 16.7 11.1 0.005 16.3 11.1 1.3 1 0 0 1 1 1 1 DNA polymerase subunit Cdc27 Nop14 PF04147.12 ETO35940.1 - 0.0073 14.6 26.2 0.009 14.3 26.2 1.0 1 0 0 1 1 1 1 Nop14-like family DNA_pol_phi PF04931.13 ETO35940.1 - 0.019 13.1 30.3 0.024 12.7 30.3 1.1 1 0 0 1 1 1 0 DNA polymerase phi Utp14 PF04615.13 ETO35940.1 - 0.044 12.4 16.9 0.051 12.2 16.9 1.0 1 0 0 1 1 1 0 Utp14 protein Mpp10 PF04006.12 ETO35940.1 - 0.058 11.8 24.6 0.075 11.5 24.6 1.1 1 0 0 1 1 1 0 Mpp10 protein BUD22 PF09073.10 ETO35940.1 - 0.18 11.1 22.2 0.22 10.8 22.2 1.1 1 0 0 1 1 1 0 BUD22 SDA1 PF05285.12 ETO35940.1 - 0.36 10.2 28.4 0.47 9.8 28.4 1.1 1 0 0 1 1 1 0 SDA1 DUF4614 PF15391.6 ETO35940.1 - 0.37 10.8 11.3 0.56 10.2 11.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4614) Nop53 PF07767.11 ETO35940.1 - 0.53 9.6 17.3 0.7 9.2 17.3 1.2 1 0 0 1 1 1 0 Nop53 (60S ribosomal biogenesis) Vfa1 PF08432.10 ETO35940.1 - 0.61 10.4 15.4 0.9 9.8 15.4 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ABC2_membrane_3 PF12698.7 ETO35940.1 - 0.97 8.5 6.1 1.4 7.9 6.1 1.2 1 0 0 1 1 1 0 ABC-2 family transporter protein eIF-3c_N PF05470.12 ETO35940.1 - 1.7 6.8 16.7 2.3 6.4 16.7 1.2 1 0 0 1 1 1 0 Eukaryotic translation initiation factor 3 subunit 8 N-terminus LAP1C PF05609.12 ETO35940.1 - 2.1 7.4 17.0 2.5 7.1 17.0 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) V_ATPase_I PF01496.19 ETO35940.1 - 4.1 5.2 8.5 5 4.9 8.5 1.3 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family DUF5123 PF17161.4 ETO35940.1 - 4.9 8.3 25.2 2.3 9.3 10.1 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5123) Macoilin PF09726.9 ETO35940.1 - 5.7 5.4 12.2 6.9 5.1 12.2 1.1 1 0 0 1 1 1 0 Macoilin family PBP_sp32 PF07222.12 ETO35940.1 - 6.7 6.1 11.0 15 4.9 11.0 1.5 1 0 0 1 1 1 0 Proacrosin binding protein sp32 CobT PF06213.12 ETO35940.1 - 9.5 5.5 25.5 13 5.0 25.5 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT Fe-ADH PF00465.19 ETO35941.1 - 2.4e-17 62.8 0.1 5.2e-17 61.7 0.0 1.6 2 0 0 2 2 2 1 Iron-containing alcohol dehydrogenase Spore_III_AB PF09548.10 ETO35941.1 - 0.0091 16.1 2.1 2.1 8.5 0.1 2.5 2 1 0 2 2 2 2 Stage III sporulation protein AB (spore_III_AB) DUF3853 PF12964.7 ETO35942.1 - 0.045 13.9 0.0 0.12 12.5 0.0 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3853) TssO PF17561.2 ETO35943.1 - 0.07 13.2 2.6 0.14 12.3 2.6 1.5 1 0 0 1 1 1 0 Type VI secretion system, TssO DUF3439 PF11921.8 ETO35944.1 - 2.6 8.0 10.1 8.8 6.3 10.1 1.9 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) SCP2 PF02036.17 ETO35945.1 - 1.9e-17 63.6 0.1 3.3e-17 62.8 0.1 1.5 1 0 0 1 1 1 1 SCP-2 sterol transfer family Alkyl_sulf_C PF14864.6 ETO35945.1 - 0.015 15.5 0.0 0.025 14.9 0.0 1.3 1 0 0 1 1 1 0 Alkyl sulfatase C-terminal PhzC-PhzF PF02567.16 ETO35946.1 - 9e-51 173.0 0.0 1.1e-50 172.7 0.0 1.1 1 0 0 1 1 1 1 Phenazine biosynthesis-like protein CholecysA-Rec_N PF09193.10 ETO35946.1 - 0.00012 21.9 0.1 0.0003 20.7 0.1 1.6 1 0 0 1 1 1 1 Cholecystokinin A receptor, N-terminal PH PF00169.29 ETO35947.1 - 2e-11 44.3 3.2 3.6e-11 43.5 0.3 2.1 2 0 0 2 2 2 1 PH domain PH_8 PF15409.6 ETO35947.1 - 7.5e-10 39.0 0.1 1.4e-09 38.1 0.1 1.4 1 0 0 1 1 1 1 Pleckstrin homology domain PH_3 PF14593.6 ETO35947.1 - 9.1e-08 32.2 0.0 1.7e-07 31.3 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO35947.1 - 0.67 10.4 9.0 0.18 12.2 0.9 2.7 2 1 1 3 3 3 0 Pleckstrin homology domain WD40 PF00400.32 ETO35950.1 - 0.0077 17.1 5.0 0.079 13.9 0.2 3.4 3 1 1 4 4 4 1 WD domain, G-beta repeat DUF5101 PF17031.5 ETO35950.1 - 0.073 13.2 0.4 0.12 12.5 0.4 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF5101) WD40 PF00400.32 ETO35952.1 - 0.12 13.3 0.2 0.27 12.2 0.2 1.7 1 0 0 1 1 1 0 WD domain, G-beta repeat REPA_OB_2 PF16900.5 ETO35953.1 - 0.0025 17.7 0.4 0.0038 17.1 0.4 1.3 1 0 0 1 1 1 1 Replication protein A OB domain BsuBI_PstI_RE PF06616.11 ETO35953.1 - 0.0093 15.3 1.3 0.019 14.3 1.3 1.6 1 1 0 1 1 1 1 BsuBI/PstI restriction endonuclease domain Orthoreo_P17 PF07272.11 ETO35953.1 - 0.02 14.9 0.3 5.3 7.0 0.4 2.2 2 1 0 2 2 2 0 Orthoreovirus P17 protein DUF3870 PF12986.7 ETO35953.1 - 0.077 13.2 0.5 0.27 11.5 0.1 1.9 1 1 1 2 2 2 0 Domain of unknown function (DUF3870) WD40 PF00400.32 ETO35954.1 - 8.5e-117 377.7 41.3 6.6e-09 36.3 0.4 16.4 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35954.1 - 1.5e-33 114.9 16.7 0.00067 19.9 0.0 12.8 1 1 12 14 14 14 10 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO35954.1 - 1.4e-17 63.7 4.7 0.053 12.5 0.0 11.3 1 1 9 12 12 12 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO35954.1 - 5.1e-16 58.9 16.1 0.0014 18.0 0.1 7.2 1 1 5 7 7 7 6 WD40-like domain Nup160 PF11715.8 ETO35954.1 - 6.3e-16 58.1 25.7 0.11 11.1 0.3 13.7 2 2 11 15 15 15 6 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO35954.1 - 5.3e-07 29.2 2.8 1.1e-06 28.2 2.8 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO35954.1 - 2.1e-05 24.3 11.4 4.3 7.4 0.0 7.9 9 0 0 9 9 8 2 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO35954.1 - 0.00024 21.2 0.2 0.00065 19.8 0.2 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Nbas_N PF15492.6 ETO35954.1 - 0.0003 20.2 14.5 4.7 6.5 0.0 8.2 3 3 8 11 11 11 1 Neuroblastoma-amplified sequence, N terminal Pentapeptide_3 PF13576.6 ETO35954.1 - 0.0032 17.6 0.6 0.0098 16.0 0.6 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO35954.1 - 0.23 11.6 2.4 1.5e+02 2.5 0.0 5.5 7 0 0 7 7 7 0 Domain of unknown function (DUF3475) Invas_SpaK PF03519.14 ETO35954.1 - 1.4 9.0 10.0 3.4 7.8 0.0 5.6 5 1 3 8 8 8 0 Invasion protein B family LZ3wCH PF18517.1 ETO35954.1 - 2.1 8.5 4.9 51 4.1 0.2 3.6 3 0 0 3 3 3 0 Leucine zipper with capping helix domain WD40 PF00400.32 ETO35955.1 - 6.7e-20 71.1 12.2 1.8e-05 25.4 0.4 4.4 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO35955.1 - 1.1e-10 40.8 0.8 0.00044 19.0 0.2 3.1 2 1 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO35955.1 - 1.2e-06 28.8 0.5 0.97 9.8 0.0 3.3 3 0 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain DUF1481 PF07356.12 ETO35955.1 - 0.18 11.6 0.7 0.48 10.2 0.1 1.9 2 0 0 2 2 2 0 Protein of unknown function (DUF1481) WD40 PF00400.32 ETO35956.1 - 2.6e-112 363.5 52.4 6.4e-08 33.1 0.3 16.0 16 0 0 16 16 16 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35956.1 - 3.4e-27 94.6 16.7 0.045 14.1 0.2 12.9 1 1 13 14 14 14 9 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO35956.1 - 5.1e-19 68.7 22.6 5.7e-06 25.9 0.0 7.6 5 2 2 8 8 8 6 WD40-like domain Ge1_WD40 PF16529.5 ETO35956.1 - 9.2e-17 61.0 6.5 0.0088 15.0 0.0 10.6 2 2 8 12 12 12 3 WD40 region of Ge1, enhancer of mRNA-decapping protein NACHT PF05729.12 ETO35956.1 - 3.7e-11 43.2 0.0 9.9e-11 41.8 0.0 1.8 2 0 0 2 2 2 1 NACHT domain Pentapeptide PF00805.22 ETO35956.1 - 2.1e-08 33.7 1.3 4.2e-08 32.7 1.3 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO35956.1 - 3.7e-05 23.5 13.0 0.0057 16.6 0.0 7.4 8 0 0 8 8 8 1 WD40-like Beta Propeller Repeat Pentapeptide_4 PF13599.6 ETO35956.1 - 0.0002 21.5 0.2 0.00051 20.2 0.2 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) AAA_18 PF13238.6 ETO35956.1 - 0.00024 21.6 0.6 0.0013 19.3 0.0 2.5 2 0 0 2 2 2 1 AAA domain PQQ_2 PF13360.6 ETO35956.1 - 0.0015 18.2 0.1 0.085 12.4 0.0 3.2 2 1 1 3 3 3 1 PQQ-like domain Str_synth PF03088.16 ETO35956.1 - 0.0021 18.2 0.6 2.8 8.1 0.0 5.3 6 1 0 6 6 5 1 Strictosidine synthase Pentapeptide_3 PF13576.6 ETO35956.1 - 0.0023 18.0 0.6 0.0057 16.8 0.6 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF3475 PF11961.8 ETO35956.1 - 0.0061 16.6 0.3 20 5.3 0.0 5.1 5 0 0 5 5 5 0 Domain of unknown function (DUF3475) AAA_22 PF13401.6 ETO35956.1 - 0.01 16.1 0.0 0.033 14.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain ATPase PF06745.13 ETO35956.1 - 0.029 13.7 0.3 1.1 8.5 0.0 2.5 2 0 0 2 2 2 0 KaiC RsgA_GTPase PF03193.16 ETO35956.1 - 0.038 13.9 0.1 0.14 12.1 0.0 2.0 2 0 0 2 2 2 0 RsgA GTPase RNA_helicase PF00910.22 ETO35956.1 - 0.057 13.8 2.3 0.9 10.0 0.0 3.4 3 0 0 3 3 2 0 RNA helicase ABC_tran PF00005.27 ETO35956.1 - 0.093 13.3 0.2 0.48 10.9 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Ras PF00071.22 ETO35957.1 - 1.7e-23 83.0 0.0 2.8e-23 82.3 0.0 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO35957.1 - 2.7e-20 72.8 0.0 4.9e-20 71.9 0.0 1.4 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO35957.1 - 6.1e-07 29.1 0.0 8.7e-07 28.6 0.0 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO35957.1 - 0.0025 17.4 0.0 0.0089 15.6 0.0 1.9 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain ALMT PF11744.8 ETO35958.1 - 0.11 11.3 0.4 0.12 11.2 0.4 1.2 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF3439 PF11921.8 ETO35959.1 - 0.51 10.3 4.2 1.3 9.0 4.2 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3439) AAA PF00004.29 ETO35961.1 - 1.1e-09 38.8 0.0 0.0001 22.7 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO35961.1 - 5.1e-07 30.1 0.0 0.026 14.8 0.0 4.8 3 1 0 3 3 3 2 AAA domain AAA_7 PF12775.7 ETO35961.1 - 2e-06 27.4 0.1 0.019 14.5 0.0 3.2 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO35961.1 - 4.3e-06 26.8 0.0 0.054 13.5 0.0 3.2 2 0 0 2 2 2 2 AAA domain (dynein-related subfamily) AAA_19 PF13245.6 ETO35961.1 - 0.00026 21.3 0.0 9.8 6.5 0.0 3.7 3 0 0 3 3 3 1 AAA domain ABC_tran PF00005.27 ETO35961.1 - 0.00098 19.6 0.2 0.0076 16.8 0.1 2.6 2 0 0 2 2 2 1 ABC transporter AAA_16 PF13191.6 ETO35961.1 - 0.0015 19.0 0.2 0.086 13.2 0.0 3.5 3 1 0 3 3 3 1 AAA ATPase domain AAA_8 PF12780.7 ETO35961.1 - 0.0016 17.8 0.0 0.0047 16.3 0.0 1.8 1 0 0 1 1 1 1 P-loop containing dynein motor region D4 DUF815 PF05673.13 ETO35961.1 - 0.002 17.3 0.1 0.02 14.0 0.0 2.6 3 0 0 3 3 3 1 Protein of unknown function (DUF815) MCM PF00493.23 ETO35961.1 - 0.0033 16.6 0.1 1.3 8.0 0.0 2.5 2 0 0 2 2 2 2 MCM P-loop domain NACHT PF05729.12 ETO35961.1 - 0.0073 16.2 4.2 0.5 10.3 0.0 4.3 4 1 0 4 4 4 1 NACHT domain RsgA_GTPase PF03193.16 ETO35961.1 - 0.014 15.3 0.0 0.043 13.7 0.0 1.8 1 0 0 1 1 1 0 RsgA GTPase TsaE PF02367.17 ETO35961.1 - 0.058 13.4 0.0 0.48 10.4 0.0 2.4 2 0 0 2 2 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE EF-hand_10 PF14788.6 ETO35961.1 - 0.067 13.1 1.2 6.2 6.8 0.0 3.9 3 1 1 4 4 4 0 EF hand Peroxin-22 PF12827.7 ETO35961.1 - 0.071 13.0 0.1 0.5 10.3 0.1 2.5 1 0 0 1 1 1 0 Peroxisomal biogenesis protein family AAA_25 PF13481.6 ETO35961.1 - 0.088 12.4 0.0 3.6 7.1 0.0 2.6 2 0 0 2 2 2 0 AAA domain PduV-EutP PF10662.9 ETO35961.1 - 0.12 12.2 0.1 0.32 10.7 0.1 1.7 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation AAA_14 PF13173.6 ETO35961.1 - 0.15 12.1 7.0 0.69 9.9 0.0 4.6 5 1 1 6 6 5 0 AAA domain DUF4050 PF13259.6 ETO35962.1 - 0.11 12.8 0.3 1.5 9.1 0.1 2.2 2 0 0 2 2 2 0 Protein of unknown function (DUF4050) LAGLIDADG_3 PF14528.6 ETO35962.1 - 0.17 12.2 1.8 1.1 9.7 0.3 2.7 2 0 0 2 2 2 0 LAGLIDADG-like domain UPF0697 PF15117.6 ETO35964.1 - 0.11 12.6 0.3 3.4 7.8 0.0 2.5 1 1 1 2 2 2 0 Uncharacterised protein family UPF0697 TAXi_N PF14543.6 ETO35965.1 - 0.37 11.0 8.4 0.49 10.6 8.4 1.3 1 0 0 1 1 1 0 Xylanase inhibitor N-terminal Pkinase PF00069.25 ETO35966.1 - 0.0029 17.0 0.1 0.0044 16.4 0.1 1.3 1 1 0 1 1 1 1 Protein kinase domain WD40 PF00400.32 ETO35967.1 - 2.7e-10 40.7 1.8 3e-05 24.7 0.4 2.6 2 1 0 2 2 2 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO35967.1 - 0.01 14.5 0.4 0.085 11.5 0.4 1.9 1 1 0 1 1 1 0 Nucleoporin Nup120/160 Snapin_Pallidin PF14712.6 ETO35968.1 - 0.067 13.6 2.5 0.16 12.4 2.5 1.6 1 0 0 1 1 1 0 Snapin/Pallidin APP_N PF02177.16 ETO35968.1 - 0.13 12.7 1.8 0.27 11.6 0.4 2.1 2 0 0 2 2 2 0 Amyloid A4 N-terminal heparin-binding Latarcin PF10279.9 ETO35968.1 - 0.56 10.6 4.6 0.33 11.4 1.7 2.0 2 0 0 2 2 2 0 Latarcin precursor RabGAP-TBC PF00566.18 ETO35969.1 - 2.2e-19 70.0 25.7 6e-19 68.6 14.1 3.7 2 1 0 2 2 2 2 Rab-GTPase-TBC domain UPRTase PF14681.6 ETO35969.1 - 1.4e-08 34.4 0.3 1.6e-06 27.7 0.1 2.7 2 1 0 2 2 2 2 Uracil phosphoribosyltransferase Rhodanese PF00581.20 ETO35969.1 - 1.7e-05 25.3 0.0 5.6e-05 23.6 0.0 2.0 1 0 0 1 1 1 1 Rhodanese-like domain DUF2251 PF10008.9 ETO35970.1 - 0.047 13.8 0.2 0.064 13.4 0.2 1.4 1 1 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2251) GDI PF00996.18 ETO35971.1 - 9e-07 27.8 0.0 9.1e-07 27.7 0.0 1.1 1 0 0 1 1 1 1 GDP dissociation inhibitor Peptidase_C14 PF00656.22 ETO35972.1 - 2.2e-12 47.5 0.1 3.1e-12 47.0 0.1 1.2 1 0 0 1 1 1 1 Caspase domain Macoilin PF09726.9 ETO35974.1 - 0.001 17.7 19.0 0.0012 17.5 19.0 1.0 1 0 0 1 1 1 1 Macoilin family RAP1 PF07218.11 ETO35974.1 - 3.4 5.9 14.5 3.9 5.6 14.5 1.1 1 0 0 1 1 1 0 Rhoptry-associated protein 1 (RAP-1) DUF4199 PF13858.6 ETO35975.1 - 0.0022 18.4 2.0 0.0044 17.4 0.1 2.4 2 0 0 2 2 2 1 Protein of unknown function (DUF4199) Ferlin_C PF16165.5 ETO35975.1 - 0.77 9.7 4.0 0.42 10.5 0.3 2.3 2 0 0 2 2 2 0 Ferlin C-terminus WD40 PF00400.32 ETO35977.1 - 3.8e-06 27.5 1.0 0.018 15.9 0.1 3.0 2 2 0 2 2 2 2 WD domain, G-beta repeat DUF3169 PF11368.8 ETO35977.1 - 0.016 14.7 3.4 0.022 14.3 3.4 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3169) TPR_10 PF13374.6 ETO35978.1 - 9.1e-07 28.6 0.0 0.0012 18.7 0.0 2.2 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO35978.1 - 9.9e-07 29.0 0.0 1.4e-06 28.5 0.0 1.2 1 0 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO35978.1 - 1e-06 28.4 1.9 7e-05 22.7 0.9 2.6 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO35978.1 - 0.002 18.1 0.8 0.35 11.1 0.3 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO35978.1 - 0.0046 16.7 2.0 0.01 15.6 0.9 2.3 2 1 0 2 2 2 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO35978.1 - 0.006 16.2 0.4 3.7 7.3 0.0 2.7 2 1 0 2 2 2 2 TPR repeat TPR_7 PF13176.6 ETO35978.1 - 0.0071 16.3 0.0 0.019 14.9 0.0 1.7 1 0 0 1 1 1 1 Tetratricopeptide repeat E1-E2_ATPase PF00122.20 ETO35979.1 - 1.3e-22 80.2 0.1 1.5e-22 80.0 0.1 1.0 1 0 0 1 1 1 1 E1-E2 ATPase DUF1449 PF07290.11 ETO35979.1 - 0.00072 19.2 3.0 0.00083 19.0 3.0 1.0 1 0 0 1 1 1 1 Protein of unknown function (DUF1449) Phage_holin_3_6 PF07332.11 ETO35979.1 - 0.0034 17.4 3.1 0.005 16.9 3.1 1.2 1 0 0 1 1 1 1 Putative Actinobacterial Holin-X, holin superfamily III Wzy_C PF04932.15 ETO35979.1 - 0.063 12.9 5.4 0.082 12.5 5.4 1.1 1 0 0 1 1 1 0 O-Antigen ligase Cation_ATPase PF13246.6 ETO35980.1 - 1.2e-18 67.0 0.1 1.8e-18 66.4 0.1 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) Hydrolase PF00702.26 ETO35980.1 - 0.0062 16.9 0.0 0.0062 16.9 0.0 1.2 1 0 0 1 1 1 1 haloacid dehalogenase-like hydrolase SLIDE PF09111.10 ETO35980.1 - 0.068 13.2 0.0 0.15 12.1 0.0 1.4 1 1 0 1 1 1 0 SLIDE Kelch_5 PF13854.6 ETO35981.1 - 0.0011 18.9 0.0 0.0086 16.1 0.0 2.2 2 0 0 2 2 2 1 Kelch motif Kelch_6 PF13964.6 ETO35981.1 - 0.036 14.4 0.5 0.1 12.9 0.2 2.0 2 1 1 3 3 3 0 Kelch motif Ank_2 PF12796.7 ETO35982.1 - 1.1e-07 32.3 0.1 0.0031 18.1 0.1 2.7 2 0 0 2 2 2 2 Ankyrin repeats (3 copies) Ank PF00023.30 ETO35982.1 - 0.0024 18.3 0.1 2.3 8.8 0.0 4.3 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO35982.1 - 0.0051 17.4 0.2 2 9.1 0.1 2.8 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO35982.1 - 0.018 15.4 0.3 0.87 10.0 0.0 3.2 2 1 1 3 3 3 0 Ankyrin repeats (many copies) FAM176 PF14851.6 ETO35982.1 - 1.8 8.3 8.2 2.1 8.0 6.5 1.9 2 0 0 2 2 2 0 FAM176 family RPA43_OB PF17875.1 ETO35982.1 - 3.2 8.4 7.4 2.2 8.9 5.2 1.8 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I RGS12_us1 PF16613.5 ETO35982.1 - 7 7.0 9.6 6.5 7.1 7.2 2.1 1 1 1 2 2 2 0 Unstructured region of RGS12 Nuc_sug_transp PF04142.15 ETO35983.1 - 2.3e-42 145.3 10.7 3.8e-42 144.5 10.7 1.3 1 1 0 1 1 1 1 Nucleotide-sugar transporter EamA PF00892.20 ETO35983.1 - 0.064 13.4 18.0 1.7 8.8 0.4 2.2 2 0 0 2 2 2 0 EamA-like transporter family Gp-FAR-1 PF05823.12 ETO35984.1 - 0.17 12.3 7.6 0.37 11.2 4.9 2.1 1 1 1 2 2 2 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) WD40 PF00400.32 ETO35985.1 - 6.3e-06 26.8 0.0 2.5e-05 24.9 0.1 1.9 2 0 0 2 2 2 1 WD domain, G-beta repeat DUF1824 PF08854.10 ETO35986.1 - 0.067 13.1 1.1 0.11 12.4 0.3 1.7 1 1 1 2 2 2 0 Domain of unknown function (DUF1824) Baculo_p24 PF05073.12 ETO35986.1 - 0.9 9.3 10.2 0.64 9.8 8.3 1.7 1 1 1 2 2 2 0 Baculovirus P24 capsid protein YtxH PF12732.7 ETO35986.1 - 1.4 9.5 5.0 14 6.3 5.0 2.3 1 1 0 1 1 1 0 YtxH-like protein DUF883 PF05957.13 ETO35986.1 - 7.2 7.3 7.8 1.5 9.5 2.9 2.1 2 0 0 2 2 2 0 Bacterial protein of unknown function (DUF883) Complex1_51K PF01512.17 ETO35987.1 - 5.3e-44 149.8 0.0 9.2e-43 145.7 0.0 2.2 1 1 0 1 1 1 1 Respiratory-chain NADH dehydrogenase 51 Kd subunit NADH_4Fe-4S PF10589.9 ETO35987.1 - 7.5e-29 99.6 0.3 2.1e-28 98.2 0.1 1.9 2 0 0 2 2 2 1 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region SLBB PF10531.9 ETO35987.1 - 8.8e-07 28.7 0.0 1.6e-06 27.9 0.0 1.4 1 0 0 1 1 1 1 SLBB domain DSPc PF00782.20 ETO35988.1 - 2.8e-26 91.9 0.6 2.8e-25 88.7 0.6 2.5 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Y_phosphatase PF00102.27 ETO35988.1 - 0.00044 19.9 3.4 0.0011 18.6 0.0 2.4 2 1 0 2 2 2 1 Protein-tyrosine phosphatase Rhodanese PF00581.20 ETO35988.1 - 0.014 15.9 0.0 0.39 11.2 0.0 2.7 2 1 1 3 3 3 0 Rhodanese-like domain SLD5_C PF16922.5 ETO35989.1 - 2.5e-10 40.4 0.0 3.8e-10 39.8 0.0 1.3 1 0 0 1 1 1 1 DNA replication complex GINS protein SLD5 C-terminus Sld5 PF05916.11 ETO35989.1 - 0.0035 17.8 2.0 0.0054 17.2 1.1 1.7 1 1 0 1 1 1 1 GINS complex protein Inp1 PF12634.7 ETO35989.1 - 0.055 13.5 0.5 4.9 7.2 0.0 2.1 2 0 0 2 2 2 0 Inheritance of peroxisomes protein 1 DUF4446 PF14584.6 ETO35990.1 - 1.1 9.3 3.3 0.49 10.4 0.3 1.7 1 1 1 2 2 2 0 Protein of unknown function (DUF4446) DUF4731 PF15875.5 ETO35991.1 - 0.04 14.1 2.2 0.081 13.1 1.3 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4731) Pyridoxal_deC PF00282.19 ETO35993.1 - 0.0079 15.0 0.0 0.013 14.2 0.0 1.4 1 0 0 1 1 1 1 Pyridoxal-dependent decarboxylase conserved domain DegT_DnrJ_EryC1 PF01041.17 ETO35994.1 - 5.4e-08 32.5 0.0 7.1e-08 32.1 0.0 1.0 1 0 0 1 1 1 1 DegT/DnrJ/EryC1/StrS aminotransferase family Aminotran_5 PF00266.19 ETO35994.1 - 0.0061 15.5 0.0 0.0075 15.3 0.0 1.0 1 0 0 1 1 1 1 Aminotransferase class-V Pyridoxal_deC PF00282.19 ETO35994.1 - 0.028 13.1 0.0 0.031 13.0 0.0 1.1 1 0 0 1 1 1 0 Pyridoxal-dependent decarboxylase conserved domain Amino_oxidase PF01593.24 ETO35995.1 - 1.3e-07 31.3 0.0 2.6e-07 30.3 0.0 1.5 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NicO PF03824.16 ETO35995.1 - 7.8 5.7 9.2 14 4.9 9.2 1.4 1 0 0 1 1 1 0 High-affinity nickel-transport protein WD40 PF00400.32 ETO35997.1 - 5.2e-21 74.6 16.9 2.2e-07 31.4 0.3 4.2 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO35997.1 - 1e-08 35.4 0.6 0.023 15.0 0.1 3.2 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO35997.1 - 1.5e-07 30.5 2.7 0.005 15.5 0.3 3.1 1 1 1 3 3 3 3 Nucleoporin Nup120/160 Pkinase PF00069.25 ETO35998.1 - 1.8e-19 70.1 0.1 2.8e-19 69.5 0.1 1.2 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO35998.1 - 3.3e-19 69.2 0.1 5.9e-19 68.3 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO35998.1 - 0.025 13.9 0.1 0.081 12.2 0.1 1.7 1 1 0 1 1 1 0 Kinase-like DUF4724 PF15852.5 ETO35998.1 - 0.033 14.7 0.2 0.074 13.5 0.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4724) LrgB PF04172.16 ETO35998.1 - 0.075 12.6 0.7 0.48 9.9 0.1 2.2 2 0 0 2 2 2 0 LrgB-like family SecG PF03840.14 ETO35998.1 - 3.5 7.8 6.1 0.27 11.4 0.6 2.1 2 0 0 2 2 2 0 Preprotein translocase SecG subunit RRM_5 PF13893.6 ETO35999.1 - 2.7e-22 78.7 0.2 8e-22 77.2 0.1 1.8 2 0 0 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) RRM_1 PF00076.22 ETO35999.1 - 3.4e-10 39.6 0.1 0.0012 18.6 0.0 2.8 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Pro-kuma_activ PF09286.11 ETO36000.1 - 2.1e-14 54.0 0.1 3.5e-14 53.3 0.1 1.3 1 0 0 1 1 1 1 Pro-kumamolisin, activation domain Kelch_1 PF01344.25 ETO36002.1 - 1.5e-08 34.1 7.3 0.004 16.7 0.6 4.1 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO36002.1 - 4.5e-08 33.0 1.0 0.02 14.9 0.1 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO36002.1 - 1.8e-05 24.5 7.1 0.035 14.1 0.1 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO36002.1 - 7.9e-05 22.8 3.5 0.0029 17.8 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_5 PF13854.6 ETO36002.1 - 0.00013 21.9 8.5 0.034 14.2 0.7 4.7 5 0 0 5 5 5 1 Kelch motif DUF2272 PF10030.9 ETO36002.1 - 0.0025 17.6 0.1 0.026 14.3 0.0 2.2 2 0 0 2 2 2 1 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_3 PF13415.6 ETO36002.1 - 0.23 11.8 0.4 7.4 7.0 0.1 3.4 3 0 0 3 3 3 0 Galactose oxidase, central domain zf-TRAF PF02176.18 ETO36003.1 - 5.3e-05 23.8 3.1 5.3e-05 23.8 3.1 2.1 2 0 0 2 2 2 1 TRAF-type zinc finger PBAN PF05874.11 ETO36003.1 - 0.072 13.0 0.0 0.11 12.4 0.0 1.2 1 0 0 1 1 1 0 Pheromone biosynthesis activating neuropeptide (PBAN) SAP PF02037.27 ETO36003.1 - 0.098 12.4 0.1 0.46 10.3 0.0 2.2 2 0 0 2 2 2 0 SAP domain Frigida PF07899.11 ETO36003.1 - 0.29 10.4 4.9 0.5 9.6 4.9 1.3 1 0 0 1 1 1 0 Frigida-like protein Beta_helix PF13229.6 ETO36005.1 - 0.022 14.6 33.0 0.017 15.0 19.3 3.5 1 1 1 2 2 2 0 Right handed beta helix region SPT2 PF08243.11 ETO36006.1 - 0.14 12.7 9.9 0.11 13.0 4.0 2.4 2 0 0 2 2 2 0 SPT2 chromatin protein YccV-like PF08755.11 ETO36006.1 - 1.4 9.4 5.3 0.79 10.3 0.7 2.4 1 1 1 2 2 2 0 Hemimethylated DNA-binding protein YccV like G_glu_transpept PF01019.21 ETO36007.1 - 3.7e-80 270.1 4.3 7.7e-54 183.3 0.3 4.1 2 2 0 2 2 2 2 Gamma-glutamyltranspeptidase Fringe PF02434.16 ETO36008.1 - 9.5e-05 22.0 0.3 0.00014 21.4 0.3 1.3 1 0 0 1 1 1 1 Fringe-like WD40 PF00400.32 ETO36009.1 - 5.5e-11 42.8 0.2 2.2e-07 31.5 0.3 2.7 2 1 0 2 2 2 2 WD domain, G-beta repeat RNA_helicase PF00910.22 ETO36010.1 - 0.0033 17.8 0.1 1.5 9.2 0.0 3.0 2 0 0 2 2 2 1 RNA helicase AAA_22 PF13401.6 ETO36010.1 - 0.022 15.1 0.5 0.66 10.3 0.1 2.9 1 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO36010.1 - 0.029 14.1 3.0 0.55 9.9 0.0 3.3 4 0 0 4 4 4 0 AAA domain Toprim PF01751.22 ETO36010.1 - 0.092 13.0 1.9 0.8 10.0 0.1 2.8 2 0 0 2 2 2 0 Toprim domain AAA_16 PF13191.6 ETO36010.1 - 0.19 12.1 0.0 0.51 10.7 0.0 1.7 1 0 0 1 1 1 0 AAA ATPase domain DUF87 PF01935.17 ETO36010.1 - 0.58 10.2 4.7 0.73 9.9 0.0 3.2 4 0 0 4 4 4 0 Helicase HerA, central domain Dynein_AAA_lid PF17852.1 ETO36011.1 - 0.021 14.9 1.7 0.036 14.2 1.2 1.5 1 1 0 1 1 1 0 Dynein heavy chain AAA lid domain DSPc PF00782.20 ETO36012.1 - 8.9e-06 25.6 5.5 0.00015 21.6 5.5 2.3 1 1 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Spc7_C2 PF15577.6 ETO36012.1 - 0.025 14.6 0.1 0.045 13.8 0.1 1.3 1 0 0 1 1 1 0 Spc7_C2 Pkinase PF00069.25 ETO36014.1 - 7.8e-46 156.6 0.0 1.3e-44 152.5 0.0 2.6 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36014.1 - 7.6e-23 81.1 0.0 1.2e-21 77.2 0.0 2.3 1 1 0 1 1 1 1 Protein tyrosine kinase Haspin_kinase PF12330.8 ETO36014.1 - 0.0012 17.9 0.2 0.015 14.3 0.0 2.1 2 0 0 2 2 2 1 Haspin like kinase domain Kdo PF06293.14 ETO36014.1 - 0.055 12.8 0.1 0.15 11.4 0.0 1.7 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family APH PF01636.23 ETO36014.1 - 0.079 12.9 0.2 0.34 10.8 0.0 2.0 2 0 0 2 2 2 0 Phosphotransferase enzyme family DUF21 PF01595.20 ETO36015.1 - 1.7e-19 70.2 0.4 4.4e-15 55.8 0.0 2.2 2 0 0 2 2 2 2 Cyclin M transmembrane N-terminal domain CBS PF00571.28 ETO36015.1 - 3e-05 24.4 1.2 0.035 14.5 0.1 3.4 3 1 0 3 3 3 2 CBS domain Thy1 PF02511.15 ETO36015.1 - 0.18 11.6 0.6 13 5.5 0.1 2.2 2 0 0 2 2 2 0 Thymidylate synthase complementing protein ETRAMP PF09716.10 ETO36016.1 - 2.8 8.1 8.7 1.3 9.1 0.1 3.7 3 0 0 3 3 3 0 Malarial early transcribed membrane protein (ETRAMP) FA_hydroxylase PF04116.13 ETO36017.1 - 7.8e-13 48.9 14.3 7.8e-13 48.9 14.3 3.4 2 1 1 3 3 3 2 Fatty acid hydroxylase superfamily EF-hand_1 PF00036.32 ETO36018.1 - 0.074 12.6 0.3 0.17 11.5 0.3 1.6 1 0 0 1 1 1 0 EF hand zf-C3HC4 PF00097.25 ETO36019.1 - 4.7e-06 26.4 8.2 4.7e-06 26.4 8.2 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO36019.1 - 4.9e-06 26.8 7.3 4.9e-06 26.8 7.3 2.0 2 0 0 2 2 2 1 Ring finger domain zf-C3HC4_2 PF13923.6 ETO36019.1 - 5.7e-05 22.9 9.6 0.00019 21.2 9.7 1.9 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO36019.1 - 7e-05 22.6 8.0 7e-05 22.6 8.0 2.0 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO36019.1 - 8.2e-05 22.5 6.0 8.2e-05 22.5 6.0 2.3 2 0 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_4 PF15227.6 ETO36019.1 - 0.00026 21.1 10.0 0.0006 19.9 10.0 1.7 1 0 0 1 1 1 1 zinc finger of C3HC4-type, RING zf-RING_UBOX PF13445.6 ETO36019.1 - 0.00076 19.5 2.9 0.00076 19.5 2.9 2.6 2 1 1 3 3 3 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ETO36019.1 - 0.003 17.4 6.2 0.003 17.4 6.2 1.8 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-rbx1 PF12678.7 ETO36019.1 - 0.0043 17.3 2.6 0.0043 17.3 2.6 2.1 2 1 1 3 3 3 1 RING-H2 zinc finger domain zf-RING_4 PF14570.6 ETO36019.1 - 0.021 14.6 5.1 0.077 12.8 5.1 2.0 1 0 0 1 1 1 0 RING/Ubox like zinc-binding domain Band_3_cyto PF07565.13 ETO36019.1 - 0.046 13.5 2.3 0.059 13.2 2.3 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain zf-ANAPC11 PF12861.7 ETO36019.1 - 0.048 13.7 2.0 0.087 12.9 2.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 11 RING-H2 finger O-antigen_lig PF13425.6 ETO36019.1 - 0.43 9.3 9.2 0.44 9.3 8.6 1.3 1 1 0 1 1 1 0 O-antigen ligase like membrane protein Peptidase_S49_N PF08496.10 ETO36019.1 - 0.44 10.6 5.5 0.74 9.9 5.5 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal LMBR1 PF04791.16 ETO36019.1 - 0.49 9.2 5.2 0.43 9.4 4.1 1.3 1 1 0 1 1 1 0 LMBR1-like membrane protein YqfQ PF14181.6 ETO36019.1 - 1.1 9.5 7.8 1.5 9.0 7.8 1.2 1 0 0 1 1 1 0 YqfQ-like protein WD40 PF00400.32 ETO36020.1 - 3.3e-36 122.7 4.2 3.3e-09 37.2 0.0 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36020.1 - 1.1e-16 60.9 0.2 0.00017 21.8 0.0 4.4 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36020.1 - 4.5e-12 45.6 0.0 0.0043 16.1 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO36020.1 - 8.4e-12 45.4 0.5 3.8e-06 26.9 0.0 2.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO36020.1 - 3.2e-07 30.0 0.4 0.014 14.7 0.0 3.0 1 1 2 3 3 3 2 WD40-like domain PD40 PF07676.12 ETO36020.1 - 4e-07 29.8 0.4 2.9 7.9 0.0 5.2 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO36020.1 - 4.8e-05 22.2 0.2 0.55 8.8 0.0 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO36020.1 - 0.00032 19.6 1.4 0.16 10.7 0.0 3.0 1 1 3 4 4 4 2 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO36020.1 - 0.00032 20.3 1.1 0.48 10.1 0.0 4.0 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature Cytochrom_D1 PF02239.16 ETO36020.1 - 0.00045 18.9 0.0 0.13 10.7 0.0 2.0 1 1 0 2 2 2 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO36020.1 - 0.0026 16.6 0.0 0.16 10.7 0.0 2.7 1 1 0 1 1 1 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF5122 PF17164.4 ETO36020.1 - 0.004 17.4 0.0 1.3 9.4 0.0 3.3 3 0 0 3 3 3 1 Domain of unknown function (DUF5122) beta-propeller VID27 PF08553.10 ETO36020.1 - 0.0088 15.1 0.0 0.03 13.4 0.0 1.7 1 1 1 2 2 2 1 VID27 C-terminal WD40-like domain DUF5570 PF17731.1 ETO36020.1 - 0.059 13.5 0.2 7.2 6.7 0.1 3.0 1 1 3 4 4 4 0 Family of unknown function (DUF5570) Invas_SpaK PF03519.14 ETO36020.1 - 0.22 11.6 4.4 14 5.8 0.0 3.5 1 1 2 3 3 3 0 Invasion protein B family Orf78 PF06024.12 ETO36021.1 - 0.028 14.7 1.5 0.046 14.0 1.5 1.3 1 0 0 1 1 1 0 Orf78 (ac78) GTP_EFTU_D2 PF03144.25 ETO36022.1 - 0.001 19.4 0.1 0.0017 18.7 0.1 1.4 1 0 0 1 1 1 1 Elongation factor Tu domain 2 WD40 PF00400.32 ETO36023.1 - 1.2e-09 38.6 1.7 0.00034 21.3 0.5 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36023.1 - 0.0011 19.2 0.0 0.018 15.3 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain NACHT PF05729.12 ETO36024.1 - 9.7e-11 41.9 0.1 1.8e-10 41.0 0.1 1.5 1 1 0 1 1 1 1 NACHT domain AAA PF00004.29 ETO36024.1 - 1.3e-06 28.8 0.0 2.5e-06 27.9 0.0 1.5 1 0 0 1 1 1 1 ATPase family associated with various cellular activities (AAA) AAA_22 PF13401.6 ETO36024.1 - 1.7e-05 25.1 0.2 0.00016 22.0 0.1 2.5 2 1 0 2 2 2 1 AAA domain NB-ARC PF00931.22 ETO36024.1 - 1.8e-05 24.1 0.2 3.2e-05 23.2 0.2 1.4 1 0 0 1 1 1 1 NB-ARC domain AFG1_ATPase PF03969.16 ETO36024.1 - 0.0001 21.4 0.1 0.00014 20.9 0.1 1.2 1 0 0 1 1 1 1 AFG1-like ATPase AAA_24 PF13479.6 ETO36024.1 - 0.00012 21.8 0.1 0.00029 20.6 0.1 1.6 1 0 0 1 1 1 1 AAA domain AAA_16 PF13191.6 ETO36024.1 - 0.00032 21.1 0.0 0.0018 18.7 0.0 2.1 1 1 0 1 1 1 1 AAA ATPase domain RNA_helicase PF00910.22 ETO36024.1 - 0.00077 19.8 0.0 0.0027 18.1 0.0 2.0 1 0 0 1 1 1 1 RNA helicase Ploopntkinase3 PF18751.1 ETO36024.1 - 0.0013 18.6 0.0 0.0021 18.0 0.0 1.3 1 0 0 1 1 1 1 P-loop Nucleotide Kinase3 AAA_32 PF13654.6 ETO36024.1 - 0.002 17.0 0.8 0.0033 16.3 0.0 1.7 2 0 0 2 2 2 1 AAA domain AAA_30 PF13604.6 ETO36024.1 - 0.0052 16.5 0.0 0.0091 15.7 0.0 1.5 1 0 0 1 1 1 1 AAA domain PhoH PF02562.16 ETO36024.1 - 0.0088 15.5 0.0 0.017 14.5 0.0 1.4 1 0 0 1 1 1 1 PhoH-like protein AAA_5 PF07728.14 ETO36024.1 - 0.013 15.5 0.1 0.33 10.9 0.0 2.5 2 1 0 2 2 2 0 AAA domain (dynein-related subfamily) ADK PF00406.22 ETO36024.1 - 0.015 15.4 1.1 0.15 12.2 0.1 2.5 2 1 0 2 2 2 0 Adenylate kinase AAA_28 PF13521.6 ETO36024.1 - 0.02 15.1 0.0 0.078 13.2 0.0 1.9 2 0 0 2 2 2 0 AAA domain ABC_tran PF00005.27 ETO36024.1 - 0.022 15.3 0.0 0.043 14.3 0.0 1.7 1 0 0 1 1 1 0 ABC transporter AAA_33 PF13671.6 ETO36024.1 - 0.025 14.7 0.4 0.23 11.6 0.0 2.4 2 1 0 2 2 2 0 AAA domain AAA_29 PF13555.6 ETO36024.1 - 0.029 14.1 0.0 0.058 13.1 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NTPase_1 PF03266.15 ETO36024.1 - 0.03 14.2 0.3 0.2 11.5 0.0 2.3 2 0 0 2 2 2 0 NTPase TsaE PF02367.17 ETO36024.1 - 0.032 14.2 0.0 0.069 13.1 0.0 1.6 1 0 0 1 1 1 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE AAA_7 PF12775.7 ETO36024.1 - 0.032 13.7 0.0 0.062 12.8 0.0 1.4 1 0 0 1 1 1 0 P-loop containing dynein motor region AAA_19 PF13245.6 ETO36024.1 - 0.037 14.3 0.0 0.072 13.4 0.0 1.6 1 1 0 1 1 1 0 AAA domain AAA_25 PF13481.6 ETO36024.1 - 0.042 13.4 0.0 0.084 12.4 0.0 1.4 1 0 0 1 1 1 0 AAA domain Sigma54_activat PF00158.26 ETO36024.1 - 0.043 13.5 0.0 0.076 12.7 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain AAA_18 PF13238.6 ETO36024.1 - 0.049 14.2 2.5 0.066 13.8 0.0 2.3 2 1 0 2 2 2 0 AAA domain SRP54 PF00448.22 ETO36024.1 - 0.055 13.1 0.0 0.1 12.2 0.0 1.4 1 0 0 1 1 1 0 SRP54-type protein, GTPase domain PduV-EutP PF10662.9 ETO36024.1 - 0.056 13.2 0.0 0.11 12.2 0.0 1.5 1 0 0 1 1 1 0 Ethanolamine utilisation - propanediol utilisation IstB_IS21 PF01695.17 ETO36024.1 - 0.056 13.2 0.1 0.093 12.5 0.1 1.4 1 1 0 1 1 1 0 IstB-like ATP binding protein Sigma54_activ_2 PF14532.6 ETO36024.1 - 0.069 13.3 0.0 0.14 12.3 0.0 1.6 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_14 PF13173.6 ETO36024.1 - 0.069 13.2 0.0 0.23 11.5 0.0 1.9 1 0 0 1 1 1 0 AAA domain DUF4199 PF13858.6 ETO36025.1 - 0.057 13.8 5.9 0.063 13.7 5.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF4199) DUF3021 PF11457.8 ETO36025.1 - 0.074 13.4 8.0 0.094 13.1 8.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3021) DHHC PF01529.20 ETO36025.1 - 0.35 11.0 4.5 0.45 10.6 4.5 1.2 1 0 0 1 1 1 0 DHHC palmitoyltransferase DUF3328 PF11807.8 ETO36025.1 - 0.48 10.2 2.1 1.1 8.9 2.1 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF3328) WD40 PF00400.32 ETO36027.1 - 6.2e-44 147.1 26.8 3.3e-07 30.9 1.0 7.8 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36027.1 - 8.4e-14 51.6 4.0 0.0027 18.0 0.0 5.5 3 2 3 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36027.1 - 4.9e-10 38.7 4.9 0.046 12.4 0.2 5.5 1 1 5 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36027.1 - 3e-06 26.8 8.8 0.4 9.9 0.1 5.3 1 1 4 6 6 6 3 WD40-like domain DUF5570 PF17731.1 ETO36027.1 - 0.038 14.1 0.5 2.1 8.4 0.0 3.1 3 1 0 3 3 3 0 Family of unknown function (DUF5570) DUF1768 PF08719.11 ETO36028.1 - 0.054 13.7 1.0 0.16 12.2 0.2 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF1768) DUF5359 PF17313.2 ETO36028.1 - 0.12 12.3 5.5 0.37 10.8 5.5 1.9 1 0 0 1 1 1 0 Family of unknown function (DUF5359) DUF4200 PF13863.6 ETO36028.1 - 4 7.9 14.4 4.6 7.7 0.4 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF4200) PAS PF00989.25 ETO36029.1 - 0.083 12.9 1.7 0.17 11.9 0.3 2.3 2 1 0 2 2 2 0 PAS fold T3SS_needle_E PF08988.10 ETO36029.1 - 0.36 11.0 7.8 0.29 11.3 4.5 2.5 1 1 1 2 2 2 0 Type III secretion system, cytoplasmic E component of needle Syntaxin PF00804.25 ETO36029.1 - 0.55 9.9 22.9 0.074 12.7 13.6 2.5 2 1 0 3 3 3 0 Syntaxin DUF4200 PF13863.6 ETO36030.1 - 0.057 13.8 1.5 0.057 13.8 1.5 4.0 3 1 0 3 3 3 0 Domain of unknown function (DUF4200) PKcGMP_CC PF16808.5 ETO36030.1 - 0.072 13.0 0.3 0.072 13.0 0.3 4.0 2 1 1 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF4284 PF14112.6 ETO36030.1 - 0.38 11.7 5.8 0.8 10.6 4.8 2.1 1 1 1 2 2 2 0 Immunity protein 22 TPR_MLP1_2 PF07926.12 ETO36030.1 - 0.55 10.3 24.7 0.08 13.0 9.2 2.8 3 0 0 3 3 3 0 TPR/MLP1/MLP2-like protein Zein-binding PF04576.15 ETO36030.1 - 0.81 10.0 15.0 0.3 11.4 0.6 3.4 3 0 0 3 3 3 0 Zein-binding DUF4201 PF13870.6 ETO36030.1 - 0.97 9.1 29.3 0.035 13.9 11.5 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4201) FlxA PF14282.6 ETO36030.1 - 1.1 9.3 29.2 0.2 11.6 4.5 4.2 3 1 1 4 4 4 0 FlxA-like protein TolA_bind_tri PF16331.5 ETO36030.1 - 1.2 9.2 21.1 1.4 9.0 1.0 3.7 2 1 1 3 3 3 0 TolA binding protein trimerisation HrpB7 PF09486.10 ETO36030.1 - 3.8 7.9 10.3 1.7 9.0 1.6 2.7 2 1 0 2 2 2 0 Bacterial type III secretion protein (HrpB7) SlyX PF04102.12 ETO36030.1 - 4.4 8.0 22.4 0.97 10.1 1.8 4.2 3 1 2 5 5 5 0 SlyX Prefoldin_2 PF01920.20 ETO36030.1 - 6.2 6.8 32.9 0.51 10.3 4.4 4.3 3 1 1 4 4 4 0 Prefoldin subunit CASP_C PF08172.12 ETO36031.1 - 8.4e-22 77.7 24.7 3.6e-20 72.4 24.7 2.0 1 1 0 1 1 1 1 CASP C terminal Striatin PF08232.12 ETO36031.1 - 0.0045 17.6 10.8 0.15 12.7 0.0 2.6 2 1 0 2 2 2 1 Striatin family CENP-H PF05837.12 ETO36031.1 - 0.017 15.5 0.4 0.017 15.5 0.4 2.9 3 1 1 4 4 4 0 Centromere protein H (CENP-H) DUF5082 PF16888.5 ETO36031.1 - 0.037 14.3 0.7 0.037 14.3 0.7 2.8 2 1 0 2 2 2 0 Domain of unknown function (DUF5082) TMF_TATA_bd PF12325.8 ETO36031.1 - 0.12 12.6 14.2 0.83 9.9 1.2 2.7 2 2 0 2 2 2 0 TATA element modulatory factor 1 TATA binding DUF3450 PF11932.8 ETO36031.1 - 0.4 10.0 11.4 0.36 10.1 1.3 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3450) DivIC PF04977.15 ETO36031.1 - 0.51 10.2 18.1 0.1 12.3 6.3 2.9 3 0 0 3 3 3 0 Septum formation initiator XhlA PF10779.9 ETO36031.1 - 0.51 10.6 6.6 0.14 12.4 1.0 2.5 2 0 0 2 2 2 0 Haemolysin XhlA CtIP_N PF10482.9 ETO36031.1 - 0.59 10.2 12.3 1.1 9.4 2.9 2.6 2 1 0 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain Menin PF05053.13 ETO36031.1 - 0.74 8.1 7.4 0.88 7.8 7.4 1.1 1 0 0 1 1 1 0 Menin bZIP_2 PF07716.15 ETO36031.1 - 2.9 8.1 15.3 0.8 9.8 1.7 3.6 2 1 1 3 3 3 0 Basic region leucine zipper DUF4407 PF14362.6 ETO36031.1 - 3.5 6.9 14.9 1.5 8.1 2.4 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4407) STAT_alpha PF01017.20 ETO36031.1 - 4.4 7.2 15.7 6.6 6.6 3.1 2.8 2 1 1 3 3 3 0 STAT protein, all-alpha domain CEP209_CC5 PF16574.5 ETO36031.1 - 4.5 7.5 13.9 4 7.6 0.7 2.7 3 0 0 3 3 3 0 Coiled-coil region of centrosome protein CE290 UPF0449 PF15136.6 ETO36031.1 - 7.4 7.1 12.4 1.9 9.0 1.8 2.6 2 0 0 2 2 2 0 Uncharacterised protein family UPF0449 HALZ PF02183.18 ETO36031.1 - 8.3 6.7 15.0 0.17 12.1 3.3 2.6 2 1 0 2 2 2 0 Homeobox associated leucine zipper CASP_C PF08172.12 ETO36032.1 - 2e-09 37.2 0.4 2.8e-09 36.7 0.4 1.2 1 0 0 1 1 1 1 CASP C terminal Gp49 PF05973.14 ETO36032.1 - 0.069 13.3 0.3 0.11 12.6 0.3 1.4 1 0 0 1 1 1 0 Phage derived protein Gp49-like (DUF891) WD40 PF00400.32 ETO36033.1 - 9.8e-14 51.5 8.9 2.3e-07 31.4 0.6 3.5 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36033.1 - 0.00043 20.5 0.9 0.16 12.3 0.2 2.8 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36033.1 - 0.015 14.0 0.5 3.3 6.2 0.0 2.7 1 1 1 3 3 3 0 Nucleoporin Nup120/160 NAAA-beta PF15508.6 ETO36034.1 - 1.2e-05 25.5 0.0 8.2e-05 22.8 0.0 2.3 2 0 0 2 2 2 1 beta subunit of N-acylethanolamine-hydrolyzing acid amidase CBAH PF02275.18 ETO36034.1 - 0.0017 18.1 0.0 0.83 9.2 0.0 2.4 2 0 0 2 2 2 2 Linear amide C-N hydrolases, choloylglycine hydrolase family Kelch_6 PF13964.6 ETO36035.1 - 1.3e-05 25.3 2.4 0.43 10.9 0.1 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO36035.1 - 0.00024 21.0 1.2 2.2 8.4 0.0 4.3 5 0 0 5 5 5 2 Kelch motif DUF4092 PF13322.6 ETO36035.1 - 0.0046 16.8 0.2 0.016 15.1 0.2 1.9 1 1 0 1 1 1 1 Domain of unknown function (DUF4092) DUF2272 PF10030.9 ETO36035.1 - 0.026 14.3 0.1 0.66 9.7 0.0 2.2 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2272) YmzC PF14157.6 ETO36035.1 - 0.2 11.8 5.3 0.14 12.3 0.9 2.9 3 0 0 3 3 3 0 YmzC-like protein BcrAD_BadFG PF01869.20 ETO36036.1 - 0.094 12.2 0.0 0.14 11.7 0.0 1.2 1 0 0 1 1 1 0 BadF/BadG/BcrA/BcrD ATPase family Methyltransf_2 PF00891.18 ETO36037.1 - 0.074 12.3 0.3 0.082 12.2 0.3 1.0 1 0 0 1 1 1 0 O-methyltransferase domain DUF4175 PF13779.6 ETO36037.1 - 0.14 10.0 2.5 0.16 9.9 2.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4175) Tim54 PF11711.8 ETO36038.1 - 0.11 11.2 6.2 0.17 10.7 6.2 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 HSP70 PF00012.20 ETO36039.1 - 0.0012 17.1 0.0 0.058 11.6 0.1 2.6 1 1 1 2 2 2 2 Hsp70 protein VWA_2 PF13519.6 ETO36039.1 - 0.04 14.6 0.0 0.15 12.7 0.0 2.0 1 0 0 1 1 1 0 von Willebrand factor type A domain RVT_1 PF00078.27 ETO36040.1 - 0.0012 18.4 0.2 0.014 14.9 0.2 2.3 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) SNARE PF05739.19 ETO36041.1 - 1.6e-14 53.6 0.2 1.6e-14 53.6 0.2 2.1 3 0 0 3 3 3 1 SNARE domain Syntaxin PF00804.25 ETO36041.1 - 2e-09 37.4 1.9 2e-09 37.4 1.9 1.9 1 1 1 2 2 2 1 Syntaxin Prominin PF05478.11 ETO36041.1 - 0.0062 14.6 0.8 0.0073 14.3 0.8 1.1 1 0 0 1 1 1 1 Prominin V-SNARE PF05008.15 ETO36041.1 - 0.013 15.9 4.0 0.082 13.3 3.0 2.0 1 1 1 2 2 2 0 Vesicle transport v-SNARE protein N-terminus SKA1 PF07160.12 ETO36041.1 - 0.02 14.7 3.0 0.025 14.4 3.0 1.1 1 0 0 1 1 1 0 Spindle and kinetochore-associated protein 1 Use1 PF09753.9 ETO36041.1 - 0.027 14.2 1.8 0.039 13.7 1.8 1.3 1 1 0 1 1 1 0 Membrane fusion protein Use1 Metal_CEHH PF14455.6 ETO36041.1 - 0.075 12.6 0.0 0.11 12.0 0.0 1.3 1 0 0 1 1 1 0 Predicted metal binding domain Pex24p PF06398.11 ETO36041.1 - 0.081 11.9 0.4 0.089 11.8 0.4 1.1 1 0 0 1 1 1 0 Integral peroxisomal membrane peroxin UPF0242 PF06785.11 ETO36041.1 - 0.62 10.1 7.6 0.61 10.2 6.7 1.5 1 1 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus PA26 PF04636.13 ETO36042.1 - 2.9e-42 145.1 0.5 4.1e-42 144.6 0.1 1.3 1 1 0 1 1 1 1 PA26 p53-induced protein (sestrin) SOG2 PF10428.9 ETO36043.1 - 0.16 11.1 10.8 0.21 10.8 10.8 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein Ribosomal_L27A PF00828.19 ETO36045.1 - 3.1e-10 40.8 0.5 7.8e-09 36.3 0.1 2.1 2 0 0 2 2 2 1 Ribosomal proteins 50S-L15, 50S-L18e, 60S-L27A Ycf70 PF17382.2 ETO36045.1 - 0.048 14.1 2.9 0.22 11.9 0.1 2.4 2 0 0 2 2 2 0 Uncharacterized Ycf70-like RSN1_TM PF13967.6 ETO36045.1 - 0.21 11.3 0.2 0.21 11.3 0.2 1.8 2 0 0 2 2 2 0 Late exocytosis, associated with Golgi transport SHOCT PF09851.9 ETO36045.1 - 0.48 10.2 0.0 0.48 10.2 0.0 2.9 3 0 0 3 3 3 0 Short C-terminal domain Helicase_C PF00271.31 ETO36046.1 - 1.6e-18 67.0 0.0 1.6e-17 63.8 0.0 2.5 2 0 0 2 2 2 1 Helicase conserved C-terminal domain DEAD PF00270.29 ETO36046.1 - 4.3e-17 62.4 0.0 8e-17 61.6 0.0 1.5 1 0 0 1 1 1 1 DEAD/DEAH box helicase RecQ_Zn_bind PF16124.5 ETO36046.1 - 1.2e-11 45.2 11.2 1.4e-11 44.9 8.4 2.8 2 1 0 2 2 2 1 RecQ zinc-binding RQC PF09382.10 ETO36046.1 - 1.8e-09 37.4 0.1 5.2e-09 35.9 0.1 1.8 1 0 0 1 1 1 1 RQC domain HRDC PF00570.23 ETO36046.1 - 0.00015 21.7 0.0 0.00055 19.9 0.0 1.9 2 0 0 2 2 2 1 HRDC domain CDC45 PF02724.14 ETO36046.1 - 0.025 12.9 5.7 0.048 12.0 5.7 1.4 1 0 0 1 1 1 0 CDC45-like protein NPR3 PF03666.13 ETO36046.1 - 0.15 10.8 11.8 0.37 9.5 11.8 1.6 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Presenilin PF01080.17 ETO36046.1 - 0.41 9.4 11.4 0.015 14.0 5.0 1.8 2 0 0 2 2 2 0 Presenilin Ndc1_Nup PF09531.10 ETO36046.1 - 0.86 8.2 3.0 1.3 7.6 3.0 1.2 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup Zip PF02535.22 ETO36046.1 - 9.9 5.3 15.6 0.12 11.6 7.9 1.7 2 0 0 2 2 2 0 ZIP Zinc transporter Secretin_N_2 PF07655.13 ETO36047.1 - 0.025 15.1 2.4 0.071 13.7 2.4 1.8 1 0 0 1 1 1 0 Secretin N-terminal domain SUIM_assoc PF16619.5 ETO36047.1 - 0.49 10.5 5.5 0.2 11.7 2.4 2.0 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 PB1 PF00564.24 ETO36048.1 - 1.7e-12 47.1 0.1 2.2e-12 46.7 0.1 1.2 1 0 0 1 1 1 1 PB1 domain NGP1NT PF08153.12 ETO36048.1 - 0.014 15.5 0.2 0.021 15.0 0.2 1.3 1 0 0 1 1 1 0 NGP1NT (NUC091) domain MMS1_N PF10433.9 ETO36048.1 - 0.029 13.0 0.1 0.033 12.8 0.1 1.1 1 0 0 1 1 1 0 Mono-functional DNA-alkylating methyl methanesulfonate N-term WD40 PF00400.32 ETO36049.1 - 5.4e-19 68.2 17.6 4.5e-06 27.3 1.2 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36049.1 - 1.4e-07 31.7 0.3 0.021 15.1 0.0 2.9 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36049.1 - 2.5e-06 26.5 3.3 0.00078 18.2 0.5 2.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36049.1 - 0.00012 21.5 0.9 0.085 12.2 0.3 2.7 1 1 2 3 3 3 3 WD40-like domain Phosphorylase PF00343.20 ETO36049.1 - 0.02 13.2 0.1 0.025 12.9 0.1 1.1 1 0 0 1 1 1 0 Carbohydrate phosphorylase CUE PF02845.16 ETO36051.1 - 0.42 10.4 5.1 8.9 6.1 0.1 3.2 3 0 0 3 3 3 0 CUE domain PHD PF00628.29 ETO36052.1 - 1.1e-08 34.8 4.9 2.4e-08 33.7 4.9 1.6 1 0 0 1 1 1 1 PHD-finger PHD_2 PF13831.6 ETO36052.1 - 0.0021 17.6 2.1 0.0021 17.6 2.1 1.7 2 0 0 2 2 2 1 PHD-finger NPR3 PF03666.13 ETO36052.1 - 0.0027 16.6 5.2 0.0036 16.2 5.2 1.1 1 0 0 1 1 1 1 Nitrogen Permease regulator of amino acid transport activity 3 FYDLN_acid PF09538.10 ETO36052.1 - 0.0096 16.6 9.4 0.0096 16.6 9.4 2.1 2 0 0 2 2 2 1 Protein of unknown function (FYDLN_acid) Presenilin PF01080.17 ETO36052.1 - 0.016 14.0 1.1 0.017 13.9 1.1 1.1 1 0 0 1 1 1 0 Presenilin FAM76 PF16046.5 ETO36052.1 - 0.032 13.6 8.5 0.03 13.7 4.9 1.9 2 0 0 2 2 2 0 FAM76 protein C1_1 PF00130.22 ETO36052.1 - 0.033 14.1 0.6 0.033 14.1 0.6 1.7 1 1 0 1 1 1 0 Phorbol esters/diacylglycerol binding domain (C1 domain) C1_2 PF03107.16 ETO36052.1 - 0.042 14.2 1.5 0.042 14.2 1.5 1.9 2 0 0 2 2 2 0 C1 domain Vfa1 PF08432.10 ETO36052.1 - 0.056 13.8 11.7 0.028 14.7 10.1 1.3 1 1 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 ORC6 PF05460.13 ETO36052.1 - 0.073 12.3 4.7 0.099 11.9 4.7 1.1 1 0 0 1 1 1 0 Origin recognition complex subunit 6 (ORC6) DUF4578 PF15147.6 ETO36052.1 - 0.098 13.5 4.4 0.16 12.9 4.4 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4578) DUF1677 PF07911.13 ETO36052.1 - 0.2 12.1 7.3 2.4 8.6 7.3 2.1 1 1 0 1 1 1 0 Protein of unknown function (DUF1677) Zip PF02535.22 ETO36052.1 - 0.23 10.6 1.0 0.29 10.3 1.0 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter DZR PF12773.7 ETO36052.1 - 0.38 10.8 4.1 13 5.9 3.6 2.4 1 1 1 2 2 2 0 Double zinc ribbon zinc_ribbon_10 PF10058.9 ETO36052.1 - 0.49 10.2 3.7 1.1 9.1 3.7 1.5 1 0 0 1 1 1 0 Predicted integral membrane zinc-ribbon metal-binding protein Zf_RING PF16744.5 ETO36052.1 - 0.57 10.3 5.3 0.13 12.3 1.3 1.9 1 1 1 2 2 2 0 KIAA1045 RING finger V_ATPase_I PF01496.19 ETO36052.1 - 1.4 6.7 5.8 1.7 6.4 5.8 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family zinc_ribbon_2 PF13240.6 ETO36052.1 - 1.4 8.7 5.3 3.5 7.5 0.1 2.8 2 0 0 2 2 2 0 zinc-ribbon domain PPL5 PF18168.1 ETO36052.1 - 1.7 7.9 11.5 2.5 7.3 11.5 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Pox_Ag35 PF03286.14 ETO36052.1 - 2.2 8.0 16.0 0.084 12.7 8.6 1.9 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Sec62 PF03839.16 ETO36052.1 - 4.2 6.8 7.4 6 6.3 7.4 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 zf-PHD-like PF15446.6 ETO36052.1 - 4.7 6.8 14.1 68 3.0 14.1 2.1 1 1 0 1 1 1 0 PHD/FYVE-zinc-finger like domain Afi1 PF07792.12 ETO36052.1 - 8.1 6.9 11.4 0.73 10.3 6.2 1.9 2 0 0 2 2 2 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF3149 PF11346.8 ETO36053.1 - 0.011 15.3 0.1 0.023 14.3 0.1 1.6 1 0 0 1 1 1 0 Protein of unknown function (DUF3149) PIF6 PF05341.11 ETO36054.1 - 0.09 12.9 0.2 0.12 12.5 0.2 1.2 1 0 0 1 1 1 0 Per os infectivity factor 6 WD40 PF00400.32 ETO36055.1 - 1.2e-06 29.2 5.5 0.014 16.3 0.5 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36055.1 - 0.011 16.1 0.0 0.018 15.3 0.0 1.5 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain NS3 PF17530.2 ETO36055.1 - 0.019 14.6 1.7 0.019 14.6 1.7 1.6 1 1 0 2 2 2 0 Non-structural protein NS3 DBP10CT PF08147.12 ETO36056.1 - 3.1 8.1 7.0 2.2 8.6 3.1 2.2 1 1 1 2 2 2 0 DBP10CT (NUC160) domain LIDHydrolase PF10230.9 ETO36057.1 - 4.2e-23 82.3 1.3 6.3e-23 81.7 1.3 1.2 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase Lipase_3 PF01764.25 ETO36057.1 - 0.0018 18.2 0.2 0.0027 17.6 0.2 1.3 1 0 0 1 1 1 1 Lipase (class 3) Hydrolase_4 PF12146.8 ETO36057.1 - 0.046 13.0 0.0 0.079 12.2 0.0 1.3 1 0 0 1 1 1 0 Serine aminopeptidase, S33 O-antigen_lig PF13425.6 ETO36057.1 - 0.046 12.5 1.7 0.064 12.0 1.7 1.3 1 0 0 1 1 1 0 O-antigen ligase like membrane protein UspB PF10625.9 ETO36057.1 - 0.05 13.6 0.7 0.05 13.6 0.7 1.8 2 0 0 2 2 2 0 Universal stress protein B (UspB) DUF4446 PF14584.6 ETO36057.1 - 0.83 9.6 5.2 5.9 6.9 0.6 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF4446) OSTbeta PF15048.6 ETO36057.1 - 1.2 9.3 5.1 11 6.2 0.0 2.7 2 1 1 3 3 3 0 Organic solute transporter subunit beta protein FAM176 PF14851.6 ETO36057.1 - 2.1 8.0 5.4 3.4 7.3 1.1 2.5 3 0 0 3 3 3 0 FAM176 family LIDHydrolase PF10230.9 ETO36058.1 - 2.2e-10 40.6 0.0 2.7e-10 40.3 0.0 1.1 1 0 0 1 1 1 1 Lipid-droplet associated hydrolase ATPase_2 PF01637.18 ETO36059.1 - 3.1e-05 24.0 1.3 3.1e-05 24.0 1.3 2.9 3 1 1 4 4 4 1 ATPase domain predominantly from Archaea AAA_16 PF13191.6 ETO36059.1 - 0.00037 20.9 0.0 0.0053 17.1 0.0 2.3 2 0 0 2 2 2 1 AAA ATPase domain AAA_22 PF13401.6 ETO36059.1 - 0.00067 19.9 0.5 0.0077 16.5 0.1 2.8 2 1 0 2 2 2 1 AAA domain AAA_7 PF12775.7 ETO36059.1 - 0.0027 17.2 0.0 0.0064 16.0 0.0 1.6 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA_24 PF13479.6 ETO36059.1 - 0.014 15.1 0.0 0.036 13.8 0.0 1.7 1 1 0 1 1 1 0 AAA domain IstB_IS21 PF01695.17 ETO36059.1 - 0.037 13.8 0.0 0.28 10.9 0.0 2.4 3 0 0 3 3 3 0 IstB-like ATP binding protein AAA PF00004.29 ETO36059.1 - 0.051 14.0 1.1 0.84 10.1 1.1 2.6 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_5 PF07728.14 ETO36059.1 - 0.064 13.2 0.0 0.13 12.3 0.0 1.5 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) RNA_helicase PF00910.22 ETO36059.1 - 0.093 13.1 0.6 1.8 9.0 0.0 2.9 3 0 0 3 3 3 0 RNA helicase AAA_33 PF13671.6 ETO36059.1 - 0.1 12.7 0.0 0.25 11.5 0.0 1.7 1 0 0 1 1 1 0 AAA domain Zeta_toxin PF06414.12 ETO36059.1 - 0.11 11.8 0.0 0.23 10.7 0.0 1.5 1 0 0 1 1 1 0 Zeta toxin AAA_11 PF13086.6 ETO36059.1 - 0.25 11.1 1.5 2.3 8.0 0.0 2.5 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 ETO36060.1 - 4e-31 106.6 25.9 1e-07 32.5 0.8 6.5 6 0 0 6 6 6 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36060.1 - 8.3e-12 45.3 1.8 0.028 14.7 0.0 4.9 2 1 3 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36060.1 - 1.1e-07 30.9 5.7 0.38 9.3 0.0 4.9 2 2 3 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36060.1 - 1.4e-06 27.8 7.6 3.1e-05 23.5 1.7 3.5 2 2 0 3 3 3 1 WD40-like domain DUF5096 PF17019.5 ETO36060.1 - 0.04 13.7 2.6 0.078 12.8 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF5096) TetM_leader PF08076.11 ETO36060.1 - 0.23 11.3 2.2 24 4.8 0.1 3.5 3 0 0 3 3 3 0 Tetracycline resistance determinant leader peptide WD40 PF00400.32 ETO36061.1 - 3e-15 56.3 15.6 5.7e-05 23.8 0.1 4.6 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO36061.1 - 0.0061 15.3 2.6 0.49 9.0 2.6 2.3 1 1 0 1 1 1 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36061.1 - 0.008 15.5 1.0 1.5 8.1 0.1 2.7 1 1 2 3 3 3 3 WD40-like domain ANAPC4_WD40 PF12894.7 ETO36061.1 - 0.012 15.9 0.5 26 5.2 0.0 3.0 2 1 1 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain LydB PF16084.5 ETO36061.1 - 0.064 13.1 0.0 0.092 12.6 0.0 1.2 1 0 0 1 1 1 0 LydA-holin antagonist WD40 PF00400.32 ETO36062.1 - 2.8e-05 24.8 1.5 0.00095 19.9 0.3 3.3 3 1 0 3 3 3 1 WD domain, G-beta repeat WD40 PF00400.32 ETO36063.1 - 1.1e-39 133.7 26.3 5.5e-07 30.2 2.2 7.0 6 1 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36063.1 - 7e-12 45.5 1.7 0.016 15.5 0.0 5.8 3 1 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36063.1 - 3e-09 36.1 9.9 0.0017 17.1 0.5 5.6 1 1 4 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36063.1 - 0.00013 21.5 11.5 0.06 12.7 1.6 4.5 2 2 3 5 5 5 3 WD40-like domain Marek_SORF3 PF07153.11 ETO36063.1 - 0.12 11.7 0.0 5.7 6.2 0.0 2.5 1 1 0 2 2 2 0 Marek's disease-like virus SORF3 protein WD40 PF00400.32 ETO36064.1 - 5.9e-16 58.6 7.0 2.3e-07 31.4 1.2 3.3 3 1 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36064.1 - 1e-05 25.8 0.0 0.0026 18.0 0.0 2.1 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36064.1 - 0.0012 17.6 0.4 0.37 9.4 0.0 2.0 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO36065.1 - 9.4e-29 99.1 5.7 3.4e-10 40.4 0.2 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36065.1 - 3e-08 33.8 0.1 0.00072 19.8 0.0 2.9 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36065.1 - 1.8e-06 27.2 0.0 0.0028 16.7 0.0 2.9 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36065.1 - 4.4e-05 23.0 0.0 0.00014 21.3 0.0 1.7 1 1 1 2 2 2 1 WD40-like domain Nucleoporin_N PF08801.11 ETO36065.1 - 0.00074 18.4 0.1 0.2 10.4 0.0 2.7 1 1 2 3 3 3 2 Nup133 N terminal like Coatomer_WDAD PF04053.14 ETO36065.1 - 0.0032 16.6 0.0 0.0034 16.5 0.0 1.0 1 0 0 1 1 1 1 Coatomer WD associated region DUF5570 PF17731.1 ETO36065.1 - 0.0052 16.9 0.0 1.7 8.8 0.0 2.6 1 1 1 3 3 3 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO36065.1 - 0.0082 16.1 0.4 5.2 7.1 0.1 3.2 3 0 0 3 3 3 1 WD40-like Beta Propeller Repeat Nup160 PF11715.8 ETO36065.1 - 0.011 14.4 0.1 0.98 8.0 0.0 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 Mid2 PF04478.12 ETO36065.1 - 0.027 14.3 0.0 5.3 6.9 0.0 2.2 2 0 0 2 2 2 0 Mid2 like cell wall stress sensor DUF4999 PF16390.5 ETO36065.1 - 0.1 12.9 0.0 14 6.0 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function CID_GANP PF16766.5 ETO36065.1 - 0.18 12.1 0.0 32 4.8 0.0 2.6 3 0 0 3 3 3 0 Binding region of GANP to ENY2 Proteasome_A_N PF10584.9 ETO36065.1 - 0.3 10.8 1.2 3.3 7.5 0.0 2.3 2 0 0 2 2 2 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO36066.1 - 5.2e-09 36.6 9.5 1.3e-05 25.9 0.9 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO36066.1 - 0.0024 16.6 1.4 0.28 9.8 0.1 2.1 1 1 1 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36066.1 - 0.019 15.3 0.6 1 9.7 0.0 2.8 3 0 0 3 3 3 0 Anaphase-promoting complex subunit 4 WD40 domain VWA PF00092.28 ETO36068.1 - 0.0022 18.3 0.0 1.1 9.5 0.0 3.1 3 0 0 3 3 3 2 von Willebrand factor type A domain VWA_2 PF13519.6 ETO36068.1 - 0.0043 17.7 0.0 0.062 14.0 0.0 2.6 2 0 0 2 2 2 1 von Willebrand factor type A domain Aa_trans PF01490.18 ETO36068.1 - 0.12 11.1 0.0 0.16 10.6 0.0 1.1 1 0 0 1 1 1 0 Transmembrane amino acid transporter protein 2Fe-2S_thioredx PF01257.19 ETO36069.1 - 5e-44 149.7 1.5 7.4e-44 149.1 1.5 1.3 1 0 0 1 1 1 1 Thioredoxin-like [2Fe-2S] ferredoxin SRP-alpha_N PF04086.13 ETO36070.1 - 0.00055 19.9 8.7 0.0009 19.3 8.7 1.3 1 0 0 1 1 1 1 Signal recognition particle, alpha subunit, N-terminal Macoilin PF09726.9 ETO36070.1 - 2 6.9 12.5 2.6 6.5 12.5 1.2 1 0 0 1 1 1 0 Macoilin family TMF_DNA_bd PF12329.8 ETO36071.1 - 0.0089 16.0 15.2 0.0089 16.0 15.2 7.1 6 1 2 8 8 8 1 TATA element modulatory factor 1 DNA binding PKcGMP_CC PF16808.5 ETO36071.1 - 0.72 9.8 24.1 0.38 10.7 1.1 4.3 3 1 1 4 4 4 0 Coiled-coil N-terminus of cGMP-dependent protein kinase CDC45 PF02724.14 ETO36072.1 - 0.35 9.1 11.9 0.47 8.7 11.9 1.1 1 0 0 1 1 1 0 CDC45-like protein NST1 PF13945.6 ETO36072.1 - 9 6.3 19.0 15 5.6 19.0 1.3 1 0 0 1 1 1 0 Salt tolerance down-regulator Gln-synt_C PF00120.24 ETO36073.1 - 2e-86 290.1 0.0 3.1e-86 289.5 0.0 1.2 1 0 0 1 1 1 1 Glutamine synthetase, catalytic domain Gln-synt_N PF03951.19 ETO36073.1 - 0.014 15.1 0.1 0.038 13.7 0.0 1.8 2 0 0 2 2 2 0 Glutamine synthetase, beta-Grasp domain DUF3270 PF11674.8 ETO36074.1 - 0.11 12.7 2.1 0.61 10.3 0.8 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF3270) TSKS PF15358.6 ETO36078.1 - 0.0028 16.1 0.1 0.0057 15.1 0.1 1.4 1 0 0 1 1 1 1 Testis-specific serine kinase substrate SUIM_assoc PF16619.5 ETO36078.1 - 2.9 8.0 13.7 0.029 14.4 5.1 2.2 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 zf-C2H2_4 PF13894.6 ETO36079.1 - 0.0022 18.7 2.6 0.023 15.5 0.2 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger DUF420 PF04238.12 ETO36079.1 - 0.0034 17.7 2.1 0.0066 16.7 2.1 1.5 1 0 0 1 1 1 1 Protein of unknown function (DUF420) zf-H2C2_2 PF13465.6 ETO36079.1 - 0.013 15.9 1.0 0.036 14.5 1.0 1.8 1 0 0 1 1 1 0 Zinc-finger double domain CpXC PF14353.6 ETO36079.1 - 0.015 15.3 1.3 0.049 13.7 0.2 2.1 1 1 1 2 2 2 0 CpXC protein Frag1 PF10277.9 ETO36079.1 - 0.02 14.5 1.5 0.021 14.4 1.5 1.2 1 0 0 1 1 1 0 Frag1/DRAM/Sfk1 family CRA PF06589.11 ETO36079.1 - 3.3 7.8 10.1 1.6 8.8 1.0 2.7 2 1 0 2 2 2 0 Circumsporozoite-related antigen (CRA) zf-C2H2 PF00096.26 ETO36080.1 - 0.071 13.6 1.1 0.071 13.6 1.1 3.0 2 1 0 2 2 2 0 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO36080.1 - 0.14 13.0 7.9 4.6 8.4 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger WD40 PF00400.32 ETO36081.1 - 1.3e-20 73.3 14.4 1.5e-06 28.8 0.5 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36081.1 - 7.5e-06 26.2 0.1 0.45 10.8 0.0 3.2 2 1 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36081.1 - 8.1e-06 24.8 2.1 0.53 8.9 0.0 3.1 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36081.1 - 0.0021 17.5 2.4 0.032 13.5 0.9 2.3 1 1 1 2 2 2 2 WD40-like domain DUF5096 PF17019.5 ETO36081.1 - 0.029 14.1 0.3 0.094 12.5 0.1 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5096) LMBR1 PF04791.16 ETO36082.1 - 1 8.2 6.0 1.5 7.7 6.0 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein TFIIE_beta PF02186.15 ETO36083.1 - 5.9e-09 36.1 0.4 1.8e-08 34.6 0.4 1.8 1 0 0 1 1 1 1 TFIIE beta subunit core domain TFA2_Winged_2 PF18121.1 ETO36083.1 - 0.00011 21.9 0.6 0.0007 19.2 0.0 2.5 3 1 0 3 3 3 1 TFA2 Winged helix domain 2 GrpB PF04229.14 ETO36083.1 - 0.055 13.7 2.8 0.064 13.4 0.2 1.9 2 0 0 2 2 2 0 GrpB protein PhoQ_Sensor PF08918.10 ETO36083.1 - 2.8 7.7 9.2 0.18 11.6 1.8 2.1 2 0 0 2 2 2 0 PhoQ Sensor DNA_pol_A_exo1 PF01612.20 ETO36084.1 - 7.5e-17 61.6 0.0 1.1e-16 61.1 0.0 1.2 1 0 0 1 1 1 1 3'-5' exonuclease uDENN PF03456.18 ETO36085.1 - 0.07 13.9 0.2 0.22 12.3 0.2 1.9 1 1 0 1 1 1 0 uDENN domain Lactamase_B PF00753.27 ETO36086.1 - 0.0017 18.4 7.4 0.03 14.3 4.8 2.6 2 1 0 2 2 2 1 Metallo-beta-lactamase superfamily Lactamase_B_2 PF12706.7 ETO36086.1 - 0.098 12.2 0.0 0.18 11.3 0.0 1.4 1 0 0 1 1 1 0 Beta-lactamase superfamily domain Alkyl_sulf_dimr PF14863.6 ETO36087.1 - 4.7e-44 150.2 0.0 7.7e-44 149.5 0.0 1.3 1 0 0 1 1 1 1 Alkyl sulfatase dimerisation Zip PF02535.22 ETO36088.1 - 1.6 7.8 3.2 2 7.5 3.2 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter TPR_MLP1_2 PF07926.12 ETO36089.1 - 7.8e-05 22.7 16.9 7.8e-05 22.7 16.9 3.3 1 1 2 3 3 3 2 TPR/MLP1/MLP2-like protein bZIP_1 PF00170.21 ETO36089.1 - 0.008 16.3 2.9 0.008 16.3 2.9 4.4 3 2 1 4 4 4 1 bZIP transcription factor Suppressor_APC PF11414.8 ETO36089.1 - 0.023 14.8 1.0 0.023 14.8 1.0 3.4 1 1 1 3 3 3 0 Adenomatous polyposis coli tumour suppressor protein Spike_torovirin PF17072.5 ETO36089.1 - 0.054 10.6 2.8 0.062 10.4 2.8 1.1 1 0 0 1 1 1 0 Torovirinae spike glycoprotein DUF1664 PF07889.12 ETO36089.1 - 1.1 9.3 16.6 0.21 11.6 7.2 2.7 1 1 0 2 2 2 0 Protein of unknown function (DUF1664) PMC2NT PF08066.12 ETO36089.1 - 9.3 7.0 14.0 0.43 11.3 1.6 3.0 1 1 0 2 2 2 0 PMC2NT (NUC016) domain Kinesin PF00225.23 ETO36090.1 - 3.4e-52 177.4 11.2 2.1e-51 174.8 11.2 2.0 1 1 0 1 1 1 1 Kinesin motor domain Thioredoxin PF00085.20 ETO36091.1 - 2.5e-21 75.6 1.6 3.4e-21 75.2 0.4 1.9 2 0 0 2 2 2 1 Thioredoxin OST3_OST6 PF04756.13 ETO36091.1 - 7.2e-08 32.1 0.2 1e-07 31.7 0.2 1.3 1 0 0 1 1 1 1 OST3 / OST6 family, transporter family Thioredoxin_2 PF13098.6 ETO36091.1 - 2.1e-05 24.9 0.4 0.00011 22.6 0.3 2.3 1 1 0 1 1 1 1 Thioredoxin-like domain TraF PF13728.6 ETO36091.1 - 0.00038 20.4 0.0 0.00067 19.5 0.0 1.4 1 0 0 1 1 1 1 F plasmid transfer operon protein Thioredoxin_8 PF13905.6 ETO36091.1 - 0.00078 19.7 0.2 0.019 15.3 0.0 3.0 2 1 0 2 2 2 1 Thioredoxin-like Thioredoxin_7 PF13899.6 ETO36091.1 - 0.0043 17.2 0.1 0.031 14.4 0.1 2.2 1 1 0 1 1 1 1 Thioredoxin-like Thioredoxin_6 PF13848.6 ETO36091.1 - 0.0046 16.9 0.2 0.014 15.4 0.0 2.0 2 0 0 2 2 2 1 Thioredoxin-like domain Choline_kinase PF01633.20 ETO36091.1 - 0.0068 16.0 3.5 0.0082 15.8 0.7 2.0 2 0 0 2 2 2 1 Choline/ethanolamine kinase AhpC-TSA PF00578.21 ETO36091.1 - 0.0078 16.1 0.2 0.024 14.5 0.1 1.9 1 1 0 1 1 1 1 AhpC/TSA family DUF4335 PF14233.6 ETO36091.1 - 0.015 15.2 1.3 0.18 11.7 0.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4335) Redoxin PF08534.10 ETO36091.1 - 0.046 13.4 0.3 0.2 11.4 0.3 2.2 1 1 0 1 1 1 0 Redoxin DUF953 PF06110.11 ETO36091.1 - 0.09 12.4 0.1 0.25 11.0 0.1 1.8 1 1 0 1 1 1 0 Eukaryotic protein of unknown function (DUF953) FragX_IP PF05994.11 ETO36092.1 - 4.6e-170 567.5 3.6 1.2e-169 566.1 3.6 1.5 1 1 0 1 1 1 1 Cytoplasmic Fragile-X interacting family zf-C3HC4 PF00097.25 ETO36093.1 - 0.095 12.6 15.8 0.27 11.1 15.7 1.9 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO36093.1 - 0.16 11.9 12.9 0.4 10.7 13.0 1.7 1 1 0 1 1 1 0 zinc-RING finger domain DUF2207 PF09972.9 ETO36093.1 - 0.35 9.6 2.8 0.43 9.3 2.8 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) zf-RING_2 PF13639.6 ETO36093.1 - 0.58 10.5 14.6 0.99 9.8 14.6 1.4 1 0 0 1 1 1 0 Ring finger domain SPT16 PF08644.11 ETO36093.1 - 1 9.5 12.4 0.05 13.8 4.9 2.3 1 1 1 2 2 2 0 FACT complex subunit (SPT16/CDC68) DUF1394 PF07159.12 ETO36095.1 - 4e-06 26.3 0.1 7.5e-06 25.4 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1394) Spo7_2_N PF15407.6 ETO36095.1 - 0.068 12.8 0.0 0.24 11.1 0.0 1.9 2 0 0 2 2 2 0 Sporulation protein family 7 Pkinase PF00069.25 ETO36098.1 - 1.7e-55 188.2 0.0 4e-54 183.7 0.0 2.2 2 1 0 2 2 2 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36098.1 - 1.1e-27 96.9 0.0 7.1e-27 94.3 0.0 2.0 1 1 0 1 1 1 1 Protein tyrosine kinase WD40 PF00400.32 ETO36099.1 - 1.4e-31 108.0 27.8 6e-06 26.9 0.9 6.9 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36099.1 - 8.2e-12 45.3 0.9 0.018 15.3 0.0 4.9 3 1 2 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36099.1 - 9.5e-11 41.0 6.0 0.035 12.7 0.2 4.1 1 1 3 4 4 4 4 Nucleoporin Nup120/160 zf-TRAF PF02176.18 ETO36100.1 - 0.0017 19.0 1.9 0.0017 19.0 1.9 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger FERM_C PF09380.10 ETO36100.1 - 0.0044 17.4 0.1 0.029 14.8 0.1 2.4 1 0 0 1 1 1 1 FERM C-terminal PH-like domain Csm1_N PF18504.1 ETO36100.1 - 0.58 10.5 10.8 0.23 11.8 7.4 2.2 2 0 0 2 2 2 0 Csm1 N-terminal domain HAP1_N PF04849.13 ETO36100.1 - 3.6 6.7 15.5 0.13 11.4 6.4 2.4 3 0 0 3 3 3 0 HAP1 N-terminal conserved region DHHC PF01529.20 ETO36101.1 - 9.7e-33 113.1 27.6 9.7e-33 113.1 27.6 2.4 2 1 1 3 3 3 1 DHHC palmitoyltransferase TctB PF07331.11 ETO36101.1 - 0.024 14.9 5.9 0.023 15.0 3.0 2.0 2 0 0 2 2 2 0 Tripartite tricarboxylate transporter TctB family SpoIIM PF01944.17 ETO36101.1 - 0.14 12.1 4.3 0.26 11.3 4.3 1.5 1 0 0 1 1 1 0 Stage II sporulation protein M Jagunal PF07086.12 ETO36101.1 - 3.8 7.5 12.3 0.56 10.3 0.2 2.2 2 0 0 2 2 2 0 Jagunal, ER re-organisation during oogenesis UPAR_LY6 PF00021.21 ETO36102.1 - 0.11 13.2 0.1 0.25 12.1 0.1 1.7 1 1 0 1 1 1 0 u-PAR/Ly-6 domain WD40 PF00400.32 ETO36104.1 - 2.2e-10 40.9 6.8 9.5e-08 32.6 1.1 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36104.1 - 0.004 17.4 0.0 0.014 15.7 0.0 1.9 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36104.1 - 0.017 14.5 0.3 0.017 14.5 0.3 2.2 1 1 1 2 2 2 0 WD40-like domain Atg14 PF10186.9 ETO36104.1 - 4.7 6.2 15.7 6.9 5.6 15.7 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 WD40 PF00400.32 ETO36105.1 - 5e-20 71.5 11.4 1e-06 29.3 0.5 3.8 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO36105.1 - 4.5e-09 35.5 2.7 0.00029 19.6 0.3 3.3 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36105.1 - 1.1e-05 25.6 0.0 0.042 14.1 0.0 3.2 2 1 1 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36105.1 - 0.00064 19.1 1.0 0.19 11.0 0.1 2.3 1 1 1 2 2 2 2 WD40-like domain HARP PF07443.13 ETO36105.1 - 0.44 10.2 4.2 6.1 6.6 0.9 3.1 3 1 0 3 3 3 0 HepA-related protein (HARP) Pox_Ag35 PF03286.14 ETO36106.1 - 0.018 14.8 10.6 0.021 14.6 10.6 1.0 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Myc_N PF01056.18 ETO36106.1 - 0.019 14.9 5.4 0.02 14.8 5.4 1.0 1 0 0 1 1 1 0 Myc amino-terminal region D123 PF07065.14 ETO36106.1 - 0.035 13.3 4.1 0.039 13.1 4.1 1.0 1 0 0 1 1 1 0 D123 RNA_pol_3_Rpc31 PF11705.8 ETO36106.1 - 0.091 13.0 10.5 0.11 12.8 10.5 1.1 1 0 0 1 1 1 0 DNA-directed RNA polymerase III subunit Rpc31 Sporozoite_P67 PF05642.11 ETO36106.1 - 0.12 10.4 5.4 0.13 10.3 5.4 1.3 1 0 0 1 1 1 0 Sporozoite P67 surface antigen O-antigen_lig PF13425.6 ETO36106.1 - 0.16 10.7 0.6 0.17 10.6 0.6 1.0 1 0 0 1 1 1 0 O-antigen ligase like membrane protein RasGAP PF00616.19 ETO36106.1 - 0.21 11.3 8.0 0.26 11.0 8.0 1.0 1 0 0 1 1 1 0 GTPase-activator protein for Ras-like GTPase PBP1_TM PF14812.6 ETO36106.1 - 0.58 10.6 10.2 0.21 12.0 5.8 2.0 2 0 0 2 2 2 0 Transmembrane domain of transglycosylase PBP1 at N-terminal Connexin PF00029.19 ETO36106.1 - 0.8 9.4 3.7 0.86 9.3 3.7 1.1 1 0 0 1 1 1 0 Connexin DUF3899 PF13038.6 ETO36106.1 - 0.95 10.0 4.2 0.3 11.6 1.4 1.5 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) DUF4611 PF15387.6 ETO36106.1 - 1.1 9.6 11.5 1 9.6 11.1 1.3 1 1 0 1 1 1 0 Domain of unknown function (DUF4611) FAM176 PF14851.6 ETO36106.1 - 1.1 8.9 9.6 1 9.0 9.1 1.3 1 1 0 1 1 1 0 FAM176 family MAP17 PF15807.5 ETO36106.1 - 5.8 7.2 8.0 7.4 6.8 8.0 1.1 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 Presenilin PF01080.17 ETO36106.1 - 6.3 5.5 5.2 6.9 5.3 5.2 1.0 1 0 0 1 1 1 0 Presenilin Cytomega_UL84 PF06284.11 ETO36106.1 - 6.3 5.1 6.3 6.3 5.1 6.3 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein NOA36 PF06524.12 ETO36107.1 - 0.25 10.6 3.6 0.4 10.0 3.6 1.2 1 0 0 1 1 1 0 NOA36 protein G-alpha PF00503.20 ETO36108.1 - 2.3e-13 50.0 0.7 2.9e-13 49.7 0.7 1.0 1 0 0 1 1 1 1 G-protein alpha subunit AA_permease_2 PF13520.6 ETO36109.1 - 4.7e-48 164.1 39.5 4.7e-48 164.1 39.5 1.7 1 1 1 2 2 2 1 Amino acid permease AA_permease PF00324.21 ETO36109.1 - 3.6e-33 114.9 43.5 6e-33 114.2 43.5 1.4 1 1 0 1 1 1 1 Amino acid permease AA_permease_C PF13906.6 ETO36109.1 - 4e-16 58.8 3.1 4e-16 58.8 3.1 5.0 6 0 0 6 6 6 1 C-terminus of AA_permease GFO_IDH_MocA PF01408.22 ETO36110.1 - 3.3e-12 47.3 0.0 5.8e-12 46.5 0.0 1.4 1 0 0 1 1 1 1 Oxidoreductase family, NAD-binding Rossmann fold DUF678 PF05077.12 ETO36111.1 - 0.034 14.3 0.7 0.034 14.3 0.7 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF678) Trypan_PARP PF05887.11 ETO36112.1 - 0.38 10.7 6.4 0.037 14.0 1.5 1.9 2 0 0 2 2 2 0 Procyclic acidic repetitive protein (PARP) DUF1336 PF07059.12 ETO36113.1 - 6.7e-24 85.2 0.0 8.1e-24 84.9 0.0 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF1336) Mob1_phocein PF03637.17 ETO36114.1 - 3.5e-41 141.0 0.0 4.3e-41 140.7 0.0 1.1 1 0 0 1 1 1 1 Mob1/phocein family TPR_12 PF13424.6 ETO36116.1 - 1.5e-151 493.0 31.8 3.6e-21 75.2 0.1 10.2 4 3 7 12 12 12 11 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36116.1 - 6.3e-103 334.3 0.2 1.3e-08 34.5 0.0 15.2 15 0 0 15 15 15 14 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36116.1 - 4.3e-99 320.7 84.7 5e-09 35.6 1.5 15.2 15 0 0 15 15 15 14 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36116.1 - 1.5e-85 275.1 21.0 3.6e-08 32.9 0.0 14.6 15 0 0 15 15 14 13 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36116.1 - 4.2e-70 226.3 64.5 1.7e-07 30.8 0.4 15.3 15 0 0 15 15 15 13 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36116.1 - 9.7e-63 203.2 86.7 1.5e-06 28.0 1.9 15.3 15 0 0 15 15 15 14 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36116.1 - 3.8e-28 95.8 33.2 0.0026 18.0 0.0 14.8 14 1 1 15 15 14 8 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36116.1 - 3.5e-25 86.9 20.7 0.21 12.3 0.1 12.7 13 0 0 13 13 12 5 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36116.1 - 4.7e-21 74.2 72.3 0.00015 21.4 0.2 18.9 16 7 6 22 22 22 7 TPR repeat TPR_16 PF13432.6 ETO36116.1 - 2.1e-17 63.5 0.0 0.037 14.7 0.0 9.7 11 1 0 11 11 9 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36116.1 - 2.5e-13 49.6 0.0 7.8 7.6 0.0 10.6 12 1 1 13 13 10 0 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO36116.1 - 3.2e-12 46.5 0.0 0.0037 16.7 0.0 4.4 2 1 1 4 4 4 3 MalT-like TPR region SHNi-TPR PF10516.9 ETO36116.1 - 5.3e-09 35.4 13.5 0.14 11.6 0.0 8.5 11 0 0 11 11 11 2 SHNi-TPR ANAPC3 PF12895.7 ETO36116.1 - 2.3e-07 30.9 36.9 0.01 16.0 0.6 8.2 4 2 3 8 8 8 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_3 PF07720.12 ETO36116.1 - 6.2e-07 29.3 53.4 0.023 14.7 1.8 9.7 10 0 0 10 10 8 4 Tetratricopeptide repeat MIT PF04212.18 ETO36116.1 - 2.3e-06 27.6 43.7 0.88 9.7 0.1 11.2 10 1 0 11 11 11 4 MIT (microtubule interacting and transport) domain TPR_19 PF14559.6 ETO36116.1 - 5.9e-05 23.5 3.2 0.53 10.8 0.0 5.9 6 2 0 6 6 5 1 Tetratricopeptide repeat TPR_9 PF13371.6 ETO36116.1 - 0.0011 19.1 0.0 18 5.6 0.0 5.5 6 3 1 7 7 5 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO36116.1 - 0.0019 17.8 28.6 0.11 12.0 0.1 6.5 8 1 0 9 9 9 4 Meiosis protein SPO22/ZIP4 like TPR_5 PF12688.7 ETO36116.1 - 0.029 14.6 0.1 14 6.0 0.0 4.4 3 1 2 5 5 4 0 Tetratrico peptide repeat TEX29 PF15839.5 ETO36116.1 - 0.45 11.1 15.2 1.5e+02 3.1 0.0 8.4 7 4 3 10 10 10 0 Testis-expressed sequence 29 protein DUF627 PF04781.12 ETO36116.1 - 0.46 10.5 18.1 1.2 9.1 0.2 6.5 5 1 3 8 8 8 0 Protein of unknown function (DUF627) DUF5113 PF17140.4 ETO36116.1 - 1 9.2 55.8 3.1 7.6 0.1 11.8 9 2 2 13 13 13 0 Domain of unknown function (DUF5113) RPN7 PF10602.9 ETO36116.1 - 1.5 8.5 34.4 0.65 9.7 0.1 8.6 3 3 4 8 8 8 0 26S proteasome subunit RPN7 Vps39_1 PF10366.9 ETO36116.1 - 5.7 7.3 9.6 15 5.9 0.0 5.1 6 0 0 6 6 6 0 Vacuolar sorting protein 39 domain 1 Ank_2 PF12796.7 ETO36117.1 - 2e-10 41.1 0.3 0.00016 22.2 0.1 2.3 1 1 1 2 2 2 2 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO36117.1 - 4.3e-06 26.7 0.1 0.02 15.4 0.0 4.0 5 0 0 5 5 5 2 Ankyrin repeat Ank_4 PF13637.6 ETO36117.1 - 1.2e-05 25.7 0.1 0.022 15.3 0.0 3.1 2 1 1 3 3 3 3 Ankyrin repeats (many copies) Ank PF00023.30 ETO36117.1 - 0.00061 20.1 0.1 0.12 12.8 0.0 3.2 3 0 0 3 3 3 1 Ankyrin repeat Ank_5 PF13857.6 ETO36117.1 - 0.00075 19.7 0.4 0.098 13.0 0.0 2.8 2 1 0 2 2 2 1 Ankyrin repeats (many copies) ArfGap PF01412.18 ETO36118.1 - 9.7e-15 54.7 2.8 1.9e-11 44.1 0.3 2.5 1 1 1 2 2 2 2 Putative GTPase activating protein for Arf Bcr-Abl_Oligo PF09036.10 ETO36119.1 - 0.1 12.6 6.3 5.3 7.1 2.3 3.1 2 0 0 2 2 2 0 Bcr-Abl oncoprotein oligomerisation domain APG6_N PF17675.1 ETO36119.1 - 0.14 12.7 37.1 1.3 9.6 0.6 3.2 1 1 2 3 3 3 0 Apg6 coiled-coil region DUF730 PF05325.11 ETO36119.1 - 0.36 10.9 3.8 0.6 10.1 1.6 2.5 1 1 2 3 3 3 0 Protein of unknown function (DUF730) Y2_Tnp PF04986.13 ETO36119.1 - 3.9 7.5 7.8 0.55 10.3 0.9 2.6 2 1 0 2 2 2 0 Putative transposase ERM PF00769.19 ETO36119.1 - 5.1 6.8 26.0 0.18 11.6 18.1 2.1 2 1 0 2 2 2 0 Ezrin/radixin/moesin family DivIC PF04977.15 ETO36119.1 - 9.4 6.1 34.4 0.07 12.9 1.0 5.2 4 2 1 5 5 5 0 Septum formation initiator LCM PF04072.14 ETO36120.1 - 5.1e-34 117.9 0.0 8e-34 117.2 0.0 1.3 1 0 0 1 1 1 1 Leucine carboxyl methyltransferase HD_2 PF12917.7 ETO36120.1 - 0.034 13.9 0.1 0.086 12.6 0.1 1.7 1 0 0 1 1 1 0 HD containing hydrolase-like enzyme NUC173 PF08161.12 ETO36121.1 - 0.013 15.2 0.2 0.022 14.4 0.2 1.3 1 0 0 1 1 1 0 NUC173 domain Trp_leader2 PF08056.11 ETO36121.1 - 0.07 13.1 0.9 0.13 12.2 0.1 1.9 2 0 0 2 2 2 0 Tryptophan operon leader peptide WD40 PF00400.32 ETO36122.1 - 2.4e-07 31.3 1.0 5.2e-07 30.3 1.0 1.6 1 0 0 1 1 1 1 WD domain, G-beta repeat WD40 PF00400.32 ETO36123.1 - 9.4e-28 95.9 11.7 8.5e-07 29.6 0.1 4.9 4 1 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36123.1 - 5.4e-11 42.6 0.6 0.002 18.4 0.0 4.5 4 1 0 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36123.1 - 8e-07 28.1 1.0 0.043 12.5 0.1 3.8 1 1 2 4 4 4 4 Nucleoporin Nup120/160 Kelch_1 PF01344.25 ETO36124.1 - 3.5e-08 32.9 2.2 4.9e-07 29.2 0.3 3.3 3 0 0 3 3 3 1 Kelch motif Kelch_6 PF13964.6 ETO36124.1 - 6.8e-05 23.0 0.8 0.092 13.1 0.1 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO36124.1 - 0.00015 21.7 0.3 0.0013 18.7 0.0 2.7 2 1 1 3 3 3 1 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO36124.1 - 0.00056 19.8 6.4 0.023 14.6 0.2 4.7 4 1 1 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO36125.1 - 4.3e-06 26.8 4.6 1.7 9.1 0.0 4.9 4 0 0 4 4 4 3 Kelch motif Kelch_1 PF01344.25 ETO36125.1 - 0.00022 20.7 1.2 0.024 14.2 0.1 3.6 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO36125.1 - 0.0044 16.9 1.3 0.19 11.8 0.1 3.7 4 0 0 4 4 4 1 Kelch motif WD40 PF00400.32 ETO36125.1 - 0.011 16.6 3.0 0.056 14.3 1.3 3.2 3 0 0 3 3 3 0 WD domain, G-beta repeat Glyco_hydro_63 PF03200.16 ETO36126.1 - 1.5e-76 258.1 9.6 3.5e-76 256.9 9.6 1.5 1 1 0 1 1 1 1 Glycosyl hydrolase family 63 C-terminal domain Trehalase PF01204.18 ETO36126.1 - 2.3e-06 26.7 1.0 3.1e-06 26.3 1.0 1.1 1 0 0 1 1 1 1 Trehalase TFIIA PF03153.13 ETO36127.1 - 0.12 12.4 31.6 0.16 12.0 31.6 1.1 1 0 0 1 1 1 0 Transcription factor IIA, alpha/beta subunit OmpH PF03938.14 ETO36128.1 - 0.026 14.9 0.1 0.037 14.3 0.1 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) ANAPC4_WD40 PF12894.7 ETO36128.1 - 0.069 13.5 0.0 0.26 11.6 0.0 2.0 2 1 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Chromo_2 PF18704.1 ETO36129.1 - 0.16 12.3 2.2 0.28 11.5 0.0 2.2 3 0 0 3 3 3 0 Chromatin organization modifier domain 2 MMR_HSR1 PF01926.23 ETO36130.1 - 4.1e-20 72.0 0.0 8.3e-20 71.0 0.0 1.5 1 0 0 1 1 1 1 50S ribosome-binding GTPase GTP1_OBG PF01018.22 ETO36130.1 - 2e-18 66.4 0.3 1.1e-17 64.1 0.3 2.1 1 1 0 1 1 1 1 GTP1/OBG FeoB_N PF02421.18 ETO36130.1 - 8.3e-07 28.7 0.0 2.5e-06 27.1 0.0 1.9 2 1 0 2 2 2 1 Ferrous iron transport protein B Arf PF00025.21 ETO36130.1 - 0.0012 18.4 0.0 0.0032 16.9 0.0 1.7 1 1 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO36130.1 - 0.0049 16.4 0.0 0.42 10.1 0.0 2.4 2 0 0 2 2 2 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO36130.1 - 0.047 13.0 0.0 0.076 12.3 0.0 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region ABC_tran PF00005.27 ETO36130.1 - 0.16 12.5 1.2 1 9.9 0.0 2.4 2 0 0 2 2 2 0 ABC transporter Methyltransf_31 PF13847.6 ETO36131.1 - 1.4e-18 67.1 0.0 1.8e-18 66.8 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO36131.1 - 5.8e-18 65.4 0.0 8.1e-18 64.9 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO36131.1 - 7e-18 65.1 0.0 1e-17 64.5 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO36131.1 - 7.3e-11 41.9 0.0 9.2e-11 41.5 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_12 PF08242.12 ETO36131.1 - 1.1e-09 39.0 0.0 1.6e-09 38.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO36131.1 - 1.7e-07 31.2 0.0 2.1e-07 30.9 0.0 1.1 1 0 0 1 1 1 1 Methyltransferase domain MTS PF05175.14 ETO36131.1 - 4.9e-05 22.9 0.0 6.9e-05 22.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase small domain Methyltransf_8 PF05148.15 ETO36131.1 - 7.3e-05 22.7 0.1 0.00098 19.0 0.1 2.0 1 1 1 2 2 2 1 Hypothetical methyltransferase Methyltransf_32 PF13679.6 ETO36131.1 - 8.1e-05 22.7 0.0 0.0001 22.3 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_16 PF10294.9 ETO36131.1 - 0.00083 19.1 0.0 0.0011 18.7 0.0 1.1 1 0 0 1 1 1 1 Lysine methyltransferase CMAS PF02353.20 ETO36131.1 - 0.0019 17.6 0.0 0.0021 17.4 0.0 1.2 1 0 0 1 1 1 1 Mycolic acid cyclopropane synthetase UPF0020 PF01170.18 ETO36131.1 - 0.0051 16.5 0.0 0.0065 16.2 0.0 1.2 1 0 0 1 1 1 1 Putative RNA methylase family UPF0020 PCMT PF01135.19 ETO36131.1 - 0.012 15.3 0.0 0.016 14.9 0.0 1.3 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 ETO36131.1 - 0.015 14.7 0.0 0.02 14.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) CheR PF01739.18 ETO36131.1 - 0.018 14.5 0.0 5.8 6.4 0.0 2.2 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain Methyltransf_4 PF02390.17 ETO36131.1 - 0.031 13.7 0.0 0.083 12.3 0.0 1.7 2 0 0 2 2 2 0 Putative methyltransferase Methyltransf_18 PF12847.7 ETO36131.1 - 0.14 12.1 0.1 0.23 11.4 0.1 1.2 1 0 0 1 1 1 0 Methyltransferase domain DUF1644 PF07800.12 ETO36132.1 - 0.15 12.1 7.0 5.2 7.1 3.1 2.8 2 1 0 2 2 2 0 Protein of unknown function (DUF1644) THOC7 PF05615.13 ETO36132.1 - 0.84 9.9 8.8 0.17 12.2 4.5 2.0 2 0 0 2 2 2 0 Tho complex subunit 7 WD40 PF00400.32 ETO36133.1 - 1e-12 48.3 8.8 1.1e-06 29.2 1.2 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36133.1 - 0.00029 21.1 0.1 0.0013 19.0 0.0 1.9 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36133.1 - 0.0011 18.4 3.2 0.0013 18.2 3.2 1.1 1 0 0 1 1 1 1 WD40-like domain Nup160 PF11715.8 ETO36133.1 - 0.0011 17.7 0.2 0.0013 17.5 0.2 1.1 1 0 0 1 1 1 1 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO36133.1 - 0.028 14.0 4.8 1.1 8.8 0.2 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) DUF4784 PF16023.5 ETO36133.1 - 0.11 11.4 0.0 0.15 11.0 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4784) WD40 PF00400.32 ETO36134.1 - 2.3e-33 113.7 27.3 3.2e-06 27.7 0.7 7.9 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36134.1 - 1.6e-08 34.7 0.4 0.095 13.0 0.0 5.2 5 0 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36134.1 - 6.8e-08 31.6 1.1 0.1 11.2 0.1 4.1 3 2 0 3 3 3 3 Nucleoporin Nup120/160 SH3_13 PF18335.1 ETO36134.1 - 0.48 10.3 7.9 4.3 7.2 0.0 4.1 4 1 0 4 4 4 0 ATP-dependent RecD-like DNA helicase SH3 domain Dynamin_M PF01031.20 ETO36135.1 - 3.6e-94 315.2 6.5 2.8e-80 269.6 0.1 3.6 2 1 0 3 3 3 2 Dynamin central region Dynamin_N PF00350.23 ETO36135.1 - 1.7e-44 151.9 0.3 6.7e-44 149.9 0.3 2.1 1 0 0 1 1 1 1 Dynamin family GED PF02212.18 ETO36135.1 - 1.3e-23 83.0 6.2 1.3e-23 83.0 6.2 1.9 2 0 0 2 2 2 1 Dynamin GTPase effector domain MMR_HSR1 PF01926.23 ETO36135.1 - 0.045 13.8 0.2 0.41 10.8 0.3 2.5 1 1 0 1 1 1 0 50S ribosome-binding GTPase T_cell_tran_alt PF15128.6 ETO36136.1 - 0.14 12.0 0.0 0.2 11.4 0.0 1.3 1 0 0 1 1 1 0 T-cell leukemia translocation-altered WD40 PF00400.32 ETO36137.1 - 6e-06 26.9 0.9 0.00076 20.2 0.1 2.5 2 1 0 2 2 2 2 WD domain, G-beta repeat WD40 PF00400.32 ETO36138.1 - 1.3e-08 35.3 5.5 1.1e-06 29.2 0.8 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36138.1 - 0.011 16.1 0.0 0.043 14.1 0.0 1.9 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain TPR_12 PF13424.6 ETO36139.1 - 1e-100 330.1 20.9 1.4e-17 63.8 0.1 8.3 3 2 5 9 9 9 9 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36139.1 - 3.5e-69 227.0 1.2 4.2e-06 26.4 0.1 13.3 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36139.1 - 1.3e-51 170.3 50.7 7.9e-08 31.8 0.0 13.2 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36139.1 - 8.1e-50 163.3 15.3 5.8e-06 26.0 0.0 13.0 13 0 0 13 13 13 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36139.1 - 1.8e-38 127.6 40.7 0.00051 19.9 1.7 13.4 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36139.1 - 1.7e-35 118.3 52.5 7.7e-06 25.7 0.1 13.0 13 0 0 13 13 13 8 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO36139.1 - 5.7e-17 62.1 0.0 4.8e-05 22.9 0.0 3.8 2 2 2 4 4 4 3 MalT-like TPR region TPR_16 PF13432.6 ETO36139.1 - 1.4e-15 57.7 2.5 0.29 11.8 0.3 9.1 8 3 3 11 11 10 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36139.1 - 1.7e-13 50.0 28.9 0.00053 19.6 0.1 10.3 11 0 0 11 11 11 5 TPR repeat TPR_14 PF13428.6 ETO36139.1 - 4.2e-12 45.8 0.0 2.7 9.1 0.0 10.3 10 1 1 11 11 11 1 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36139.1 - 1.7e-10 40.5 12.1 0.17 12.3 0.2 10.5 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36139.1 - 4.7e-10 39.4 8.5 0.48 11.2 0.2 9.8 10 0 0 10 10 10 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO36139.1 - 7.6e-10 39.2 0.1 5.1 7.7 0.0 7.4 5 1 2 7 7 7 1 Tetratricopeptide repeat DUF5113 PF17140.4 ETO36139.1 - 6.7e-06 26.0 22.9 2.9 7.7 0.0 9.7 11 0 0 11 11 11 2 Domain of unknown function (DUF5113) PPR PF01535.20 ETO36139.1 - 0.00011 22.2 9.5 3.2 8.2 0.0 6.6 7 0 0 7 7 6 2 PPR repeat ANAPC3 PF12895.7 ETO36139.1 - 0.02 15.1 21.6 1.8 8.9 0.1 7.2 4 3 4 8 8 8 0 Anaphase-promoting complex, cyclosome, subunit 3 CLN3 PF02487.17 ETO36139.1 - 0.026 13.6 0.8 0.042 12.9 0.8 1.2 1 0 0 1 1 1 0 CLN3 protein TPR_21 PF09976.9 ETO36139.1 - 0.048 13.4 2.7 0.4 10.4 0.0 3.7 4 0 0 4 4 4 0 Tetratricopeptide repeat-like domain MIT PF04212.18 ETO36139.1 - 0.36 10.9 25.4 2 8.5 0.0 9.3 11 1 1 12 12 12 0 MIT (microtubule interacting and transport) domain SPO22 PF08631.10 ETO36139.1 - 0.38 10.2 11.1 12 5.3 0.8 5.1 5 2 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like DUF3856 PF12968.7 ETO36139.1 - 1.2 9.2 10.9 2.5 8.2 0.2 5.4 3 2 3 7 7 6 0 Domain of Unknown Function (DUF3856) TPR_3 PF07720.12 ETO36139.1 - 3.3 7.8 0.0 3.3 7.8 0.0 7.4 8 0 0 8 8 8 0 Tetratricopeptide repeat WD40 PF00400.32 ETO36140.1 - 3e-38 129.1 18.9 7.5e-07 29.8 0.7 7.1 6 2 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36140.1 - 1.3e-11 44.6 2.8 0.17 12.2 0.0 5.9 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36140.1 - 2e-07 30.6 12.3 0.00014 21.3 0.5 4.2 1 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO36140.1 - 2.4e-07 29.8 4.8 0.36 9.4 0.1 5.0 1 1 4 5 5 5 5 Nucleoporin Nup120/160 NosL PF05573.12 ETO36141.1 - 0.07 13.5 0.2 0.16 12.3 0.2 1.5 1 0 0 1 1 1 0 NosL FWWh PF14922.6 ETO36141.1 - 0.55 10.2 7.7 1.8 8.5 1.4 2.7 2 1 1 3 3 3 0 Protein of unknown function SOG2 PF10428.9 ETO36142.1 - 0.013 14.7 2.0 0.015 14.5 2.0 1.0 1 0 0 1 1 1 0 RAM signalling pathway protein Bud13 PF09736.9 ETO36142.1 - 0.94 9.9 5.4 0.31 11.4 0.5 2.1 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex TPK_catalytic PF04263.16 ETO36143.1 - 0.034 14.2 0.0 0.059 13.4 0.0 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain PDZ_6 PF17820.1 ETO36144.1 - 2.9e-07 30.2 0.0 3.2e-06 26.9 0.0 2.2 2 0 0 2 2 2 1 PDZ domain PDZ PF00595.24 ETO36144.1 - 6.9e-05 23.1 0.0 0.00017 21.8 0.0 1.6 1 0 0 1 1 1 1 PDZ domain DENN PF02141.21 ETO36146.1 - 6.7e-42 143.5 4.2 1.3e-41 142.6 4.2 1.5 1 0 0 1 1 1 1 DENN (AEX-3) domain uDENN PF03456.18 ETO36146.1 - 1.5e-13 51.2 0.8 4.8e-13 49.6 0.8 2.0 1 0 0 1 1 1 1 uDENN domain N_BRCA1_IG PF16158.5 ETO36149.1 - 1.8e-23 83.2 0.3 5.3e-23 81.7 0.0 1.9 2 0 0 2 2 2 1 Ig-like domain from next to BRCA1 gene ZZ PF00569.17 ETO36149.1 - 8.6e-11 41.5 29.0 8.7e-11 41.5 11.4 2.8 2 1 0 2 2 2 2 Zinc finger, ZZ type DUF2052 PF09747.9 ETO36149.1 - 0.057 13.5 26.9 1.4 9.0 2.6 3.1 3 0 0 3 3 3 0 Coiled-coil domain containing protein (DUF2052) Tubulin PF00091.25 ETO36151.1 - 1.3e-25 90.8 0.0 6.3e-24 85.3 0.0 2.1 1 1 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain Tubulin_C PF03953.17 ETO36152.1 - 4.9e-06 26.7 3.0 0.0041 17.3 1.0 2.2 1 1 1 2 2 2 2 Tubulin C-terminal domain tRNA-synt_1c_C PF03950.18 ETO36152.1 - 0.065 13.1 0.2 0.17 11.8 0.1 1.6 1 1 1 2 2 2 0 tRNA synthetases class I (E and Q), anti-codon binding domain Kelch_1 PF01344.25 ETO36154.1 - 0.0028 17.2 0.3 0.0081 15.7 0.2 1.8 2 0 0 2 2 2 1 Kelch motif Kelch_2 PF07646.15 ETO36154.1 - 0.0044 17.0 2.5 0.052 13.5 1.2 2.6 2 1 0 2 2 2 1 Kelch motif Kelch_4 PF13418.6 ETO36154.1 - 0.0051 16.8 0.9 0.074 13.1 0.4 2.5 2 1 1 3 3 3 1 Galactose oxidase, central domain SNX17_FERM_C PF18116.1 ETO36154.1 - 0.0069 16.4 0.2 0.031 14.4 0.0 1.9 2 0 0 2 2 2 1 Sorting Nexin 17 FERM C-terminal domain Kelch_6 PF13964.6 ETO36154.1 - 0.015 15.6 1.9 1.6 9.1 0.6 2.8 2 2 0 2 2 2 0 Kelch motif Kelch_3 PF13415.6 ETO36154.1 - 0.017 15.4 0.1 0.37 11.1 0.0 2.8 3 0 0 3 3 3 0 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO36155.1 - 7.7e-06 26.0 2.4 0.17 12.3 0.0 3.7 3 0 0 3 3 3 2 Kelch motif Kelch_4 PF13418.6 ETO36155.1 - 1.8e-05 24.6 0.5 0.038 14.0 0.0 3.5 3 0 0 3 3 3 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO36155.1 - 0.0057 16.6 3.7 2.9 8.0 0.0 4.4 3 1 0 3 3 3 2 Kelch motif Kelch_1 PF01344.25 ETO36155.1 - 0.0076 15.8 4.3 0.66 9.6 0.1 3.5 3 1 0 3 3 3 1 Kelch motif ICMT PF04140.14 ETO36156.1 - 1.5e-28 99.1 1.5 4.7e-28 97.4 1.5 1.8 1 0 0 1 1 1 1 Isoprenylcysteine carboxyl methyltransferase (ICMT) family PEMT PF04191.13 ETO36156.1 - 6.4e-10 39.4 2.6 6.4e-10 39.4 2.6 2.1 2 0 0 2 2 2 1 Phospholipid methyltransferase Oxidored_q3 PF00499.20 ETO36156.1 - 0.031 14.0 0.1 0.031 14.0 0.1 2.2 2 1 0 2 2 2 0 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 DUF389 PF04087.14 ETO36156.1 - 0.071 13.1 2.3 1.9 8.5 0.1 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF389) DUF1295 PF06966.12 ETO36156.1 - 0.12 11.8 3.8 0.5 9.8 3.8 2.0 1 1 0 1 1 1 0 Protein of unknown function (DUF1295) NAPRTase_N PF17767.1 ETO36158.1 - 6.3e-21 75.1 0.4 9e-21 74.5 0.4 1.3 1 0 0 1 1 1 1 Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain CUE PF02845.16 ETO36158.1 - 0.016 14.9 0.1 0.038 13.7 0.1 1.7 1 0 0 1 1 1 0 CUE domain KH_1 PF00013.29 ETO36159.1 - 3.6e-05 23.5 0.1 6.5e-05 22.7 0.1 1.5 1 0 0 1 1 1 1 KH domain DUF3340 PF11818.8 ETO36159.1 - 0.043 14.0 3.2 0.094 12.9 3.2 1.5 1 0 0 1 1 1 0 C-terminal domain of tail specific protease (DUF3340) SPX PF03105.19 ETO36159.1 - 2.2 8.1 17.7 2.8 7.8 17.7 1.1 1 0 0 1 1 1 0 SPX domain Macoilin PF09726.9 ETO36159.1 - 7.8 4.9 20.9 8.9 4.7 20.9 1.1 1 0 0 1 1 1 0 Macoilin family GREB1 PF15782.5 ETO36159.1 - 9.1 3.2 17.5 11 3.0 17.5 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer TPR_12 PF13424.6 ETO36160.1 - 3e-79 261.3 16.5 1.4e-16 60.5 0.1 6.6 4 1 3 7 7 7 6 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36160.1 - 4.9e-59 194.7 0.7 5.9e-07 29.2 0.0 9.4 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36160.1 - 1.1e-55 183.2 46.2 3.1e-08 33.1 0.8 9.5 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36160.1 - 4.1e-47 154.8 16.3 5.2e-07 29.3 0.1 9.5 9 0 0 9 9 9 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36160.1 - 9.9e-46 150.2 46.1 3.2e-06 26.9 0.6 9.6 9 0 0 9 9 9 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36160.1 - 2.1e-45 149.2 36.2 1e-05 25.3 0.1 9.7 10 0 0 10 10 9 8 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36160.1 - 9.8e-22 76.4 29.4 0.0027 17.4 0.1 9.3 9 2 0 9 9 9 6 TPR repeat TPR_6 PF13174.6 ETO36160.1 - 5.9e-17 61.1 16.6 0.099 13.3 0.0 8.7 8 0 0 8 8 8 4 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36160.1 - 1.5e-15 56.4 11.7 0.37 11.3 0.0 9.5 9 0 0 9 9 9 4 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36160.1 - 6.6e-14 51.4 0.4 3.1 8.9 0.0 8.1 8 0 0 8 8 8 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36160.1 - 3.4e-11 43.6 0.0 0.24 12.1 0.0 6.2 5 2 0 5 5 5 3 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO36160.1 - 2.6e-09 36.4 9.7 0.021 14.3 0.0 7.0 8 0 0 8 8 8 2 SHNi-TPR TPR_19 PF14559.6 ETO36160.1 - 2.4e-08 34.4 2.7 0.027 15.0 0.0 5.1 3 2 3 6 6 6 1 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO36160.1 - 1.9e-07 30.8 0.0 0.023 14.1 0.0 3.1 1 1 0 2 2 2 1 MalT-like TPR region MIT PF04212.18 ETO36160.1 - 2.5e-06 27.5 25.2 0.66 10.1 0.1 7.9 7 1 1 8 8 8 1 MIT (microtubule interacting and transport) domain ANAPC3 PF12895.7 ETO36160.1 - 2.5e-06 27.6 22.4 0.0076 16.5 0.7 6.2 4 3 1 5 5 5 2 Anaphase-promoting complex, cyclosome, subunit 3 DUF5113 PF17140.4 ETO36160.1 - 3.7e-06 26.9 26.9 4.6 7.0 0.2 8.8 5 3 3 9 9 9 1 Domain of unknown function (DUF5113) TPR_9 PF13371.6 ETO36160.1 - 0.00024 21.2 0.0 5.9 7.1 0.0 5.0 4 1 0 4 4 4 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO36160.1 - 0.00025 21.0 34.3 0.022 14.8 0.1 8.4 8 0 0 8 8 8 2 Tetratricopeptide repeat PPR PF01535.20 ETO36160.1 - 0.0003 20.8 7.0 25 5.4 0.0 6.6 7 0 0 7 7 7 0 PPR repeat DUF3856 PF12968.7 ETO36160.1 - 0.00075 19.6 6.6 0.14 12.2 0.1 4.0 2 1 2 4 4 4 1 Domain of Unknown Function (DUF3856) NRBF2_MIT PF17169.4 ETO36160.1 - 0.007 16.6 5.7 2.4 8.4 0.0 4.8 4 1 1 5 5 5 1 MIT domain of nuclear receptor-binding factor 2 Peptidase_C14 PF00656.22 ETO36160.1 - 0.02 14.8 0.9 0.056 13.4 0.9 1.7 1 1 0 1 1 1 0 Caspase domain Sel1 PF08238.12 ETO36160.1 - 0.026 15.2 7.3 61 4.5 0.0 5.6 6 0 0 6 6 5 0 Sel1 repeat HTH_Bact PF18768.1 ETO36160.1 - 0.05 13.2 11.1 4.2 7.0 0.0 6.8 6 1 1 7 7 7 0 Helix-turn-helix bacterial domain DUF627 PF04781.12 ETO36160.1 - 0.073 13.1 3.1 25 4.9 0.1 3.8 3 0 0 3 3 3 0 Protein of unknown function (DUF627) YflT PF11181.8 ETO36160.1 - 0.13 12.8 1.2 29 5.3 0.0 3.5 2 1 0 2 2 2 0 Heat induced stress protein YflT SLT PF01464.20 ETO36160.1 - 0.13 11.9 1.5 0.49 10.1 0.0 2.8 4 0 0 4 4 3 0 Transglycosylase SLT domain OEP PF02321.18 ETO36160.1 - 0.17 11.7 1.3 4.8 7.0 0.0 2.6 2 0 0 2 2 2 0 Outer membrane efflux protein PPR_2 PF13041.6 ETO36160.1 - 1.3 9.3 4.4 17 5.7 0.0 4.4 5 0 0 5 5 5 0 PPR repeat family Fis1_TPR_C PF14853.6 ETO36160.1 - 1.7 8.7 8.6 2.1 8.5 0.1 4.4 5 0 0 5 5 4 0 Fis1 C-terminal tetratricopeptide repeat RPN7 PF10602.9 ETO36160.1 - 5.9 6.6 18.2 52 3.5 0.1 6.2 3 2 3 6 6 6 0 26S proteasome subunit RPN7 RRN3 PF05327.11 ETO36161.1 - 5e-30 104.6 18.4 5.9e-24 84.5 6.6 3.4 3 1 0 3 3 3 2 RNA polymerase I specific transcription initiation factor RRN3 Metallophos PF00149.28 ETO36162.1 - 1.7e-05 25.4 0.0 2.5e-05 24.9 0.0 1.3 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Vpu PF00558.19 ETO36162.1 - 0.16 11.8 2.0 0.28 11.0 2.0 1.4 1 0 0 1 1 1 0 Vpu protein DUF3556 PF12077.8 ETO36164.1 - 0.0089 14.5 0.4 0.01 14.3 0.4 1.1 1 0 0 1 1 1 1 Transmembrane protein of unknown function (DUF3556) Myticin-prepro PF10690.9 ETO36164.1 - 0.23 11.7 2.2 0.25 11.6 0.4 1.9 2 0 0 2 2 2 0 Myticin pre-proprotein from the mussel WD40 PF00400.32 ETO36165.1 - 0.034 15.0 0.5 0.034 15.0 0.5 2.4 3 0 0 3 3 3 0 WD domain, G-beta repeat Ig_6 PF18452.1 ETO36165.1 - 0.046 13.3 0.8 0.071 12.7 0.5 1.5 1 1 0 1 1 1 0 Immunoglobulin domain Methyltransf_11 PF08241.12 ETO36166.1 - 1.8e-15 57.3 0.0 5.7e-15 55.7 0.0 1.8 1 1 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO36166.1 - 5.5e-13 48.8 0.0 8.8e-13 48.1 0.0 1.3 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_25 PF13649.6 ETO36166.1 - 2.6e-12 47.3 0.1 9.7e-12 45.4 0.1 2.0 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO36166.1 - 5.2e-08 32.8 0.0 9e-08 32.1 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_23 PF13489.6 ETO36166.1 - 2.2e-05 24.4 0.0 3.1e-05 23.9 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO36166.1 - 0.0001 23.0 0.0 0.00021 22.0 0.0 1.6 1 0 0 1 1 1 1 Methyltransferase domain CheR PF01739.18 ETO36166.1 - 0.054 13.0 0.1 0.4 10.2 0.0 2.0 1 1 1 2 2 2 0 CheR methyltransferase, SAM binding domain RhoGAP PF00620.27 ETO36167.1 - 2.8e-30 105.2 3.0 9.1e-30 103.5 0.1 2.5 2 0 0 2 2 2 1 RhoGAP domain Sulfotransfer_4 PF17784.1 ETO36168.1 - 1e-23 84.3 0.0 1.5e-23 83.8 0.0 1.2 1 0 0 1 1 1 1 Sulfotransferase domain Sulfotransfer_3 PF13469.6 ETO36168.1 - 0.00093 19.6 1.5 0.041 14.2 0.1 2.2 1 1 0 2 2 2 1 Sulfotransferase family DUF4105 PF13387.6 ETO36168.1 - 0.055 13.1 0.1 0.41 10.3 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4105) AAA_18 PF13238.6 ETO36168.1 - 0.1 13.2 0.1 0.7 10.4 0.1 2.2 1 1 0 1 1 1 0 AAA domain zf-TRAF PF02176.18 ETO36169.1 - 0.0013 19.4 1.9 0.002 18.8 0.8 2.0 2 0 0 2 2 2 1 TRAF-type zinc finger Cytochrom_C1 PF02167.15 ETO36173.1 - 7.6e-34 117.3 0.0 1.8e-32 112.9 0.0 2.0 2 0 0 2 2 2 2 Cytochrome C1 family TPR_12 PF13424.6 ETO36174.1 - 0.00019 21.6 0.1 0.0013 19.0 0.1 2.1 1 1 1 2 2 2 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36174.1 - 0.00046 19.9 1.3 0.00046 19.9 1.3 2.7 2 2 1 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36174.1 - 0.00087 19.2 3.1 0.0052 16.8 0.5 2.9 2 1 1 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36174.1 - 0.0048 16.7 0.4 0.043 13.7 0.0 2.1 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36174.1 - 0.13 12.3 0.2 0.32 11.1 0.2 1.6 1 0 0 1 1 1 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36175.1 - 8e-09 34.9 1.3 7.2e-05 22.4 0.3 2.8 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36175.1 - 4.5e-07 29.4 0.2 0.052 13.6 0.0 3.0 2 1 1 3 3 3 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36175.1 - 1.7e-05 24.6 0.5 0.0072 16.4 0.3 2.7 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO36175.1 - 3.5e-05 24.0 0.0 8.8e-05 22.7 0.0 1.7 1 1 0 1 1 1 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36175.1 - 0.0013 18.8 5.4 0.43 10.9 1.2 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat MIT PF04212.18 ETO36175.1 - 0.012 15.6 0.4 1.7 8.8 0.1 2.5 2 0 0 2 2 2 0 MIT (microtubule interacting and transport) domain TPR_10 PF13374.6 ETO36175.1 - 0.049 13.5 0.0 3.4 7.7 0.0 2.4 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF3856 PF12968.7 ETO36175.1 - 0.089 12.9 0.5 0.43 10.6 0.1 1.9 2 0 0 2 2 2 0 Domain of Unknown Function (DUF3856) AsnC_trans_reg PF01037.21 ETO36176.1 - 0.069 13.1 0.1 0.35 10.9 0.1 2.3 2 0 0 2 2 2 0 Lrp/AsnC ligand binding domain Baculo_PEP_C PF04513.12 ETO36176.1 - 0.1 12.6 1.3 0.83 9.7 0.3 2.5 2 0 0 2 2 2 0 Baculovirus polyhedron envelope protein, PEP, C terminus DASH_Dam1 PF08653.10 ETO36176.1 - 0.31 10.9 1.0 5.1 7.0 0.3 3.3 4 0 0 4 4 4 0 DASH complex subunit Dam1 Fer2 PF00111.27 ETO36178.1 - 5.3e-12 45.5 0.1 9.3e-12 44.7 0.1 1.4 1 0 0 1 1 1 1 2Fe-2S iron-sulfur cluster binding domain Reeler PF02014.16 ETO36178.1 - 0.021 15.6 0.4 0.032 15.0 0.4 1.3 1 0 0 1 1 1 0 Reeler domain PH_3 PF14593.6 ETO36179.1 - 0.054 13.6 0.1 0.15 12.2 0.0 1.7 1 1 1 2 2 2 0 PH domain DUF4094 PF13334.6 ETO36179.1 - 0.099 13.1 0.1 4.2 7.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4094) FLYWCH PF04500.16 ETO36179.1 - 4.9 7.3 7.1 3.9 7.7 0.9 3.0 2 1 1 3 3 3 0 FLYWCH zinc finger domain DUF3877 PF12993.7 ETO36180.1 - 0.11 12.4 4.7 0.13 12.1 4.7 1.1 1 0 0 1 1 1 0 Domain of unknown function, E. rectale Gene description (DUF3877) dsRBD2 PF17842.1 ETO36180.1 - 0.16 12.2 5.2 0.37 11.0 5.2 1.7 1 1 0 1 1 1 0 Double-stranded RNA binding domain 2 Apt1 PF10351.9 ETO36180.1 - 0.48 9.2 10.2 0.53 9.1 10.2 1.2 1 0 0 1 1 1 0 Golgi-body localisation protein domain SpecificRecomb PF10136.9 ETO36180.1 - 1.1 7.5 7.9 1.3 7.3 7.9 1.0 1 0 0 1 1 1 0 Site-specific recombinase DUF5327 PF17261.2 ETO36180.1 - 1.8 9.4 13.0 0.14 12.9 6.2 2.1 1 1 1 2 2 2 0 Family of unknown function (DUF5327) Cnd3 PF12719.7 ETO36181.1 - 8.8e-39 133.4 5.8 8.8e-39 133.4 5.8 3.2 2 1 0 2 2 2 1 Nuclear condensing complex subunits, C-term domain DUF1664 PF07889.12 ETO36181.1 - 2.9 8.0 7.5 4.7 7.3 5.8 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) eIF3_subunit PF08597.10 ETO36182.1 - 0.85 9.5 13.1 1.3 8.9 13.1 1.1 1 0 0 1 1 1 0 Translation initiation factor eIF3 subunit Presenilin PF01080.17 ETO36182.1 - 5.6 5.6 5.7 7.1 5.3 5.7 1.1 1 0 0 1 1 1 0 Presenilin RRM_1 PF00076.22 ETO36183.1 - 0.00023 20.9 0.0 0.00052 19.8 0.0 1.5 1 0 0 1 1 1 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) 2OG-FeII_Oxy_2 PF13532.6 ETO36184.1 - 1.7e-19 70.8 1.1 2.2e-19 70.4 1.1 1.1 1 0 0 1 1 1 1 2OG-Fe(II) oxygenase superfamily V_ATPase_I PF01496.19 ETO36185.1 - 1.3e-142 476.6 9.0 1.4e-142 476.4 9.0 1.0 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family DUF4834 PF16118.5 ETO36185.1 - 0.23 12.5 2.5 0.37 11.8 0.0 2.5 3 0 0 3 3 3 0 Domain of unknown function (DUF4834) V_ATPase_I PF01496.19 ETO36186.1 - 5.7e-66 223.0 0.5 7.1e-66 222.7 0.5 1.1 1 0 0 1 1 1 1 V-type ATPase 116kDa subunit family RCR PF12273.8 ETO36186.1 - 0.1 13.3 0.1 0.23 12.1 0.1 1.5 1 0 0 1 1 1 0 Chitin synthesis regulation, resistance to Congo red E3_UbLigase_R4 PF13764.6 ETO36187.1 - 0.0099 14.1 3.7 0.013 13.7 3.7 1.1 1 0 0 1 1 1 1 E3 ubiquitin-protein ligase UBR4 Spb1_C PF07780.12 ETO36187.1 - 0.037 13.7 6.9 0.051 13.2 6.9 1.1 1 0 0 1 1 1 0 Spb1 C-terminal domain zf-C3HC4_3 PF13920.6 ETO36187.1 - 4.1 7.3 7.8 1.9 8.4 2.4 2.7 2 1 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) DHC PF09626.10 ETO36188.1 - 0.033 15.1 0.2 0.073 14.0 0.0 1.6 1 1 0 1 1 1 0 Dihaem cytochrome c WD40 PF00400.32 ETO36189.1 - 1.8e-16 60.2 23.9 1.2e-05 25.9 3.4 4.3 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36189.1 - 1.4e-05 25.3 0.6 0.058 13.7 0.1 3.0 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36189.1 - 0.0051 15.5 2.2 0.065 11.9 2.0 2.6 1 1 1 2 2 2 1 Nucleoporin Nup120/160 DUF4221 PF13970.6 ETO36189.1 - 0.072 12.6 3.2 0.75 9.3 0.1 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4221) MMR_HSR1 PF01926.23 ETO36190.1 - 2.7e-08 33.9 0.3 9.7e-08 32.1 0.0 2.1 2 1 0 2 2 2 1 50S ribosome-binding GTPase RHD3 PF05879.12 ETO36190.1 - 3.9e-07 28.7 1.6 6e-07 28.0 0.0 1.9 2 0 0 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) GBP PF02263.19 ETO36190.1 - 9.8e-07 28.3 2.5 2.4e-06 27.0 0.1 2.5 2 1 0 2 2 2 1 Guanylate-binding protein, N-terminal domain Dynamin_N PF00350.23 ETO36190.1 - 0.00011 22.4 1.3 0.0018 18.3 0.0 2.5 2 0 0 2 2 2 1 Dynamin family AAA_16 PF13191.6 ETO36190.1 - 0.0094 16.3 0.0 0.022 15.1 0.0 1.6 1 0 0 1 1 1 1 AAA ATPase domain ABC_tran PF00005.27 ETO36190.1 - 0.037 14.6 0.5 0.17 12.4 0.0 2.1 1 1 1 2 2 2 0 ABC transporter AAA_28 PF13521.6 ETO36190.1 - 0.048 13.9 0.7 0.19 12.0 0.1 2.3 3 0 0 3 3 3 0 AAA domain FtsK_SpoIIIE PF01580.18 ETO36190.1 - 0.19 11.1 1.5 0.24 10.7 0.1 1.8 2 0 0 2 2 2 0 FtsK/SpoIIIE family Cep57_MT_bd PF06657.13 ETO36190.1 - 5.2 7.6 8.2 4.2 7.9 5.1 2.2 2 0 0 2 2 2 0 Centrosome microtubule-binding domain of Cep57 DUF3342 PF11822.8 ETO36191.1 - 0.24 11.6 3.4 0.42 10.8 3.4 1.6 1 1 0 1 1 1 0 Domain of unknown function (DUF3342) HSDR_N PF04313.14 ETO36193.1 - 0.023 14.6 2.9 0.043 13.8 2.9 1.4 1 0 0 1 1 1 0 Type I restriction enzyme R protein N terminus (HSDR_N) N6_N4_Mtase PF01555.18 ETO36193.1 - 0.028 14.1 2.5 0.036 13.8 2.5 1.2 1 0 0 1 1 1 0 DNA methylase Exo_endo_phos_2 PF14529.6 ETO36193.1 - 0.084 12.7 1.2 0.24 11.3 0.2 2.3 2 1 1 3 3 3 0 Endonuclease-reverse transcriptase DUF4094 PF13334.6 ETO36194.1 - 0.0019 18.6 4.6 0.0026 18.1 4.6 1.3 1 1 0 1 1 1 1 Domain of unknown function (DUF4094) FAM76 PF16046.5 ETO36194.1 - 0.0079 15.6 4.0 0.009 15.4 4.0 1.0 1 0 0 1 1 1 1 FAM76 protein DUF812 PF05667.11 ETO36194.1 - 0.01 14.8 4.7 0.012 14.6 4.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF812) DUF848 PF05852.11 ETO36194.1 - 0.019 15.1 3.0 0.022 14.9 3.0 1.1 1 0 0 1 1 1 0 Gammaherpesvirus protein of unknown function (DUF848) UPF0242 PF06785.11 ETO36194.1 - 0.024 14.7 6.6 0.027 14.6 6.6 1.0 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus DUF3573 PF12097.8 ETO36194.1 - 0.099 11.5 1.8 0.11 11.3 1.8 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF3573) PFU PF09070.11 ETO36195.1 - 0.061 13.6 0.0 0.072 13.4 0.0 1.3 1 0 0 1 1 1 0 PFU (PLAA family ubiquitin binding) Endonuc_Holl PF10107.9 ETO36196.1 - 0.0012 18.8 2.2 0.0014 18.5 2.2 1.1 1 0 0 1 1 1 1 Endonuclease related to archaeal Holliday junction resolvase DUF4856 PF16148.5 ETO36196.1 - 0.04 12.9 2.0 0.044 12.8 2.0 1.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4856) Cytadhesin_P30 PF07271.11 ETO36196.1 - 0.3 10.6 1.4 0.28 10.7 1.4 1.1 1 0 0 1 1 1 0 Cytadhesin P30/P32 COMM_domain PF07258.14 ETO36197.1 - 2.5e-05 24.3 1.8 6e-05 23.1 0.2 2.1 2 0 0 2 2 2 1 COMM domain WD40 PF00400.32 ETO36199.1 - 4e-05 24.3 0.1 0.00011 22.9 0.1 1.8 1 0 0 1 1 1 1 WD domain, G-beta repeat Lyase_aromatic PF00221.19 ETO36200.1 - 8.7e-190 631.3 0.0 9.8e-190 631.1 0.0 1.0 1 0 0 1 1 1 1 Aromatic amino acid lyase DERM PF14704.6 ETO36201.1 - 0.0037 17.8 0.7 0.012 16.1 0.1 1.9 1 1 0 2 2 2 1 Dermatopontin DUF16 PF01519.16 ETO36201.1 - 8.9 6.9 13.3 2.1 8.9 2.1 2.3 2 0 0 2 2 2 0 Protein of unknown function DUF16 TLD PF07534.16 ETO36202.1 - 7.8e-10 39.1 0.1 1.4e-09 38.3 0.1 1.4 1 0 0 1 1 1 1 TLD Sec3-PIP2_bind PF15277.6 ETO36202.1 - 0.053 13.7 0.4 2.1 8.6 0.3 3.0 2 1 0 2 2 2 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH BSP_II PF05432.11 ETO36202.1 - 5.3 6.7 7.4 7.1 6.2 7.4 1.1 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) CAP_GLY PF01302.25 ETO36203.1 - 4.5e-43 145.1 3.7 3.9e-22 78.0 0.2 2.3 2 0 0 2 2 2 2 CAP-Gly domain WD40 PF00400.32 ETO36205.1 - 7e-60 197.6 25.6 9.9e-10 38.9 0.2 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36205.1 - 1.9e-21 76.1 8.4 0.00049 20.3 0.3 6.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36205.1 - 2.9e-11 42.9 0.2 0.084 11.8 0.0 5.3 2 2 4 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36205.1 - 2.4e-08 33.6 6.5 0.0031 16.9 0.2 3.5 1 1 4 5 5 5 5 WD40-like domain DUF5570 PF17731.1 ETO36205.1 - 9.5e-05 22.5 0.8 7.9 6.6 0.1 4.6 1 1 3 5 5 5 1 Family of unknown function (DUF5570) PQQ PF01011.21 ETO36205.1 - 0.0011 18.8 0.3 31 4.7 0.0 5.0 5 0 0 5 5 5 0 PQQ enzyme repeat Coatomer_WDAD PF04053.14 ETO36205.1 - 0.0078 15.3 5.1 0.4 9.7 0.2 3.2 1 1 2 3 3 3 2 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO36205.1 - 0.014 14.0 0.9 3.1 6.2 0.0 2.9 1 1 3 4 4 4 0 Cytochrome D1 heme domain PD40 PF07676.12 ETO36205.1 - 0.044 13.7 1.6 58 3.8 0.1 4.5 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat DUF5449 PF17528.2 ETO36205.1 - 0.095 12.5 0.9 2.1 8.1 0.1 2.6 1 1 1 3 3 3 0 Family of unknown function (DUF5449) Abhydro_lipase PF04083.16 ETO36205.1 - 0.13 11.9 0.0 0.31 10.6 0.0 1.7 1 0 0 1 1 1 0 Partial alpha/beta-hydrolase lipase region WD40 PF00400.32 ETO36206.1 - 2e-62 205.7 23.4 4.7e-11 43.1 0.4 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36206.1 - 2.1e-14 53.6 5.9 0.027 14.8 0.0 6.3 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36206.1 - 2.1e-10 40.1 4.6 0.0053 15.8 0.0 4.7 1 1 5 6 6 6 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO36206.1 - 3.2e-10 39.3 7.4 0.0046 15.7 0.2 5.3 2 1 4 6 6 6 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36206.1 - 4.2e-09 36.1 1.0 0.00012 21.5 0.6 2.6 1 1 1 2 2 2 2 WD40-like domain Nucleoporin_N PF08801.11 ETO36206.1 - 0.0003 19.7 6.7 2.1 7.0 0.2 4.3 1 1 2 4 4 4 3 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO36206.1 - 0.0063 15.1 0.1 0.93 8.0 0.0 2.7 2 1 1 3 3 3 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO36206.1 - 0.011 15.7 0.0 19 5.3 0.0 3.7 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat DUF5046 PF16465.5 ETO36206.1 - 0.083 12.3 0.0 0.89 8.9 0.0 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF5046) HARP PF07443.13 ETO36206.1 - 0.12 12.1 0.2 27 4.5 0.0 4.2 5 1 1 6 6 6 0 HepA-related protein (HARP) TauE PF01925.19 ETO36207.1 - 4e-16 59.4 6.1 1.1e-08 35.1 0.1 2.3 3 0 0 3 3 3 2 Sulfite exporter TauE/SafE GIT_CC PF16559.5 ETO36208.1 - 0.096 12.6 0.1 0.19 11.6 0.1 1.4 1 0 0 1 1 1 0 GIT coiled-coil Rho guanine nucleotide exchange factor RVT_1 PF00078.27 ETO36209.1 - 0.0082 15.7 0.0 0.017 14.7 0.0 1.5 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Exo_endo_phos PF03372.23 ETO36211.1 - 2.4e-06 27.2 0.0 6.1e-06 25.9 0.0 1.7 1 1 0 1 1 1 1 Endonuclease/Exonuclease/phosphatase family RsgI_N PF12791.7 ETO36211.1 - 0.017 15.1 0.1 0.042 13.8 0.1 1.7 1 0 0 1 1 1 0 Anti-sigma factor N-terminus TMEM43 PF07787.12 ETO36212.1 - 0.00017 21.1 0.0 0.00026 20.4 0.0 1.5 1 0 0 1 1 1 1 Transmembrane protein 43 DENN PF02141.21 ETO36213.1 - 0.006 16.6 0.0 0.01 15.8 0.0 1.4 1 0 0 1 1 1 1 DENN (AEX-3) domain AF-4 PF05110.13 ETO36213.1 - 0.27 9.3 8.4 0.35 8.9 8.4 1.1 1 0 0 1 1 1 0 AF-4 proto-oncoprotein uDENN PF03456.18 ETO36213.1 - 3.1 8.6 5.5 2.5 8.9 1.6 2.7 2 1 0 2 2 2 0 uDENN domain DHHC PF01529.20 ETO36214.1 - 3.7e-30 104.8 2.1 3.7e-30 104.8 2.1 2.8 3 1 0 3 3 3 1 DHHC palmitoyltransferase MIB_HERC2 PF06701.13 ETO36215.1 - 2.7e-40 136.5 23.6 3.1e-21 75.4 2.9 5.3 5 0 0 5 5 5 5 Mib_herc2 DUF3337 PF11816.8 ETO36215.1 - 0.095 12.6 4.7 0.17 11.7 4.7 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3337) DUF3915 PF13054.6 ETO36215.1 - 0.096 12.7 2.0 0.21 11.6 2.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) UBA PF00627.31 ETO36215.1 - 0.18 11.7 0.0 0.36 10.8 0.0 1.5 1 0 0 1 1 1 0 UBA/TS-N domain Atrophin-1 PF03154.15 ETO36215.1 - 0.28 9.4 5.1 0.37 9.0 5.1 1.1 1 0 0 1 1 1 0 Atrophin-1 family MAS20 PF02064.15 ETO36215.1 - 0.82 9.8 6.1 1.4 9.0 6.1 1.3 1 0 0 1 1 1 0 MAS20 protein import receptor DUF3304 PF11745.8 ETO36215.1 - 0.9 10.0 5.2 1.1 9.7 3.1 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3304) SAM_PNT PF02198.16 ETO36216.1 - 0.0051 16.8 0.2 0.0089 16.0 0.2 1.4 1 0 0 1 1 1 1 Sterile alpha motif (SAM)/Pointed domain SAM_2 PF07647.17 ETO36216.1 - 0.0075 16.4 0.0 0.013 15.5 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) Nop14 PF04147.12 ETO36216.1 - 0.0079 14.5 21.5 0.011 13.9 21.5 1.1 1 0 0 1 1 1 1 Nop14-like family DUF2052 PF09747.9 ETO36216.1 - 0.012 15.7 18.1 0.012 15.7 18.1 1.5 2 0 0 2 2 1 0 Coiled-coil domain containing protein (DUF2052) RR_TM4-6 PF06459.12 ETO36216.1 - 0.013 15.4 16.5 0.018 14.9 16.5 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pox_Ag35 PF03286.14 ETO36216.1 - 0.021 14.6 17.9 0.032 14.0 17.9 1.3 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Myc_N PF01056.18 ETO36216.1 - 0.024 14.6 11.0 0.031 14.2 11.0 1.2 1 0 0 1 1 1 0 Myc amino-terminal region SAM_1 PF00536.30 ETO36216.1 - 0.04 14.4 0.0 0.07 13.6 0.0 1.4 1 0 0 1 1 1 0 SAM domain (Sterile alpha motif) DDHD PF02862.17 ETO36216.1 - 0.043 14.0 5.5 0.061 13.5 5.5 1.3 1 0 0 1 1 1 0 DDHD domain PPL5 PF18168.1 ETO36216.1 - 0.064 12.6 9.1 0.096 12.0 9.1 1.2 1 0 0 1 1 1 0 Prim-pol family 5 Neur_chan_memb PF02932.16 ETO36216.1 - 0.092 12.8 3.0 0.1 12.6 3.0 1.2 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region Dsh_C PF12316.8 ETO36216.1 - 0.092 13.1 6.5 0.15 12.5 6.5 1.3 1 0 0 1 1 1 0 Segment polarity protein dishevelled (Dsh) C terminal YABBY PF04690.13 ETO36216.1 - 0.12 12.9 5.6 0.21 12.1 5.6 1.4 1 0 0 1 1 1 0 YABBY protein CDC45 PF02724.14 ETO36216.1 - 0.14 10.5 15.4 0.18 10.0 15.4 1.2 1 0 0 1 1 1 0 CDC45-like protein TFIIF_alpha PF05793.12 ETO36216.1 - 0.15 10.6 22.7 0.2 10.2 22.7 1.1 1 0 0 1 1 1 0 Transcription initiation factor IIF, alpha subunit (TFIIF-alpha) SID-1_RNA_chan PF13965.6 ETO36216.1 - 0.16 10.4 3.3 0.21 9.9 3.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 DUF4471 PF14740.6 ETO36216.1 - 0.16 11.2 7.4 0.22 10.7 7.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4471) RNA_pol_Rpc4 PF05132.14 ETO36216.1 - 0.28 11.6 11.8 0.55 10.7 11.8 1.6 1 0 0 1 1 1 0 RNA polymerase III RPC4 Ferlin_C PF16165.5 ETO36216.1 - 0.43 10.5 9.0 0.7 9.8 9.0 1.5 1 0 0 1 1 1 0 Ferlin C-terminus Bud13 PF09736.9 ETO36216.1 - 0.49 10.8 20.7 0.097 13.1 16.6 1.9 2 0 0 2 2 2 0 Pre-mRNA-splicing factor of RES complex SDA1 PF05285.12 ETO36216.1 - 0.74 9.2 26.1 0.14 11.5 23.0 1.3 2 0 0 2 2 1 0 SDA1 LAP1C PF05609.12 ETO36216.1 - 0.81 8.7 15.5 1.1 8.3 15.5 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) DUF853 PF05872.12 ETO36216.1 - 0.94 8.0 6.4 1 7.9 6.4 1.1 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF853) RPN2_C PF18004.1 ETO36216.1 - 0.97 9.3 27.0 0.073 13.0 22.2 1.5 2 0 0 2 2 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain NPR3 PF03666.13 ETO36216.1 - 1.1 8.0 13.9 1.4 7.6 13.9 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SpoIIP PF07454.11 ETO36216.1 - 1.2 8.6 16.5 2.1 7.8 16.5 1.4 1 0 0 1 1 1 0 Stage II sporulation protein P (SpoIIP) PDCD2_C PF04194.13 ETO36216.1 - 1.5 8.8 15.9 2.2 8.3 14.6 1.8 2 0 0 2 2 2 0 Programmed cell death protein 2, C-terminal putative domain Vfa1 PF08432.10 ETO36216.1 - 1.6 9.0 23.7 3.1 8.1 23.7 1.4 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 SLC12 PF03522.15 ETO36216.1 - 2.2 7.2 13.9 3 6.8 13.9 1.2 1 0 0 1 1 1 0 Solute carrier family 12 CPSF100_C PF13299.6 ETO36216.1 - 2.3 8.4 15.5 4 7.6 15.5 1.4 1 0 0 1 1 1 0 Cleavage and polyadenylation factor 2 C-terminal Atrophin-1 PF03154.15 ETO36216.1 - 2.4 6.3 12.6 3.1 6.0 12.6 1.2 1 0 0 1 1 1 0 Atrophin-1 family Presenilin PF01080.17 ETO36216.1 - 3.3 6.4 16.9 4.2 6.0 16.9 1.1 1 0 0 1 1 1 0 Presenilin DUF913 PF06025.12 ETO36216.1 - 4.4 6.2 12.6 6 5.7 12.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF913) ALMT PF11744.8 ETO36216.1 - 4.4 6.0 13.0 6.1 5.6 13.0 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter TFB6 PF17110.5 ETO36216.1 - 4.7 6.9 11.2 7.9 6.2 11.2 1.4 1 0 0 1 1 1 0 Subunit 11 of the general transcription factor TFIIH PI3K_1B_p101 PF10486.9 ETO36216.1 - 4.8 4.8 12.6 6 4.5 12.6 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Afi1 PF07792.12 ETO36216.1 - 5.2 7.6 13.0 11 6.5 13.0 1.6 1 0 0 1 1 1 0 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF4820 PF16091.5 ETO36216.1 - 5.7 6.2 13.9 8.8 5.6 13.9 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) PA26 PF04636.13 ETO36216.1 - 6.1 5.6 12.6 9.1 5.1 12.6 1.2 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) Membralin PF09746.9 ETO36216.1 - 7.1 5.6 11.6 11 5.0 11.6 1.2 1 0 0 1 1 1 0 Tumour-associated protein NARP1 PF12569.8 ETO36216.1 - 7.6 5.3 20.6 12 4.7 20.6 1.2 1 0 0 1 1 1 0 NMDA receptor-regulated protein 1 CobT PF06213.12 ETO36216.1 - 7.7 5.8 22.5 12 5.2 22.5 1.3 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT MDM10 PF12519.8 ETO36216.1 - 8.4 5.1 10.8 10 4.9 10.8 1.1 1 0 0 1 1 1 0 Mitochondrial distribution and morphology protein 10 CCSAP PF15748.5 ETO36216.1 - 8.5 6.5 21.6 0.92 9.6 16.9 1.7 2 0 0 2 2 2 0 Centriole, cilia and spindle-associated Connexin PF00029.19 ETO36216.1 - 9.1 6.0 14.8 13 5.4 14.8 1.2 1 0 0 1 1 1 0 Connexin zf-C3HC4_3 PF13920.6 ETO36218.1 - 2.6e-09 36.8 6.8 2.6e-09 36.8 6.8 2.3 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO36218.1 - 8e-06 25.6 8.7 8e-06 25.6 8.7 2.4 2 0 0 2 2 2 1 Prokaryotic RING finger family 4 zf-RING_2 PF13639.6 ETO36218.1 - 0.00011 22.5 8.3 0.00011 22.5 8.3 2.3 2 0 0 2 2 2 1 Ring finger domain zf-P11 PF03854.14 ETO36218.1 - 0.0017 18.0 7.2 0.0027 17.3 3.5 3.1 3 0 0 3 3 3 1 P-11 zinc finger Tudor-knot PF11717.8 ETO36218.1 - 0.0022 17.8 0.5 0.0054 16.6 0.5 1.7 1 0 0 1 1 1 1 RNA binding activity-knot of a chromodomain zf-RING_5 PF14634.6 ETO36218.1 - 0.0035 17.3 10.7 0.0035 17.3 10.7 2.5 2 1 0 2 2 2 1 zinc-RING finger domain zf-C3HC4_2 PF13923.6 ETO36218.1 - 0.025 14.4 11.4 1.5 8.7 12.6 3.1 1 1 1 2 2 2 0 Zinc finger, C3HC4 type (RING finger) Med27 PF11571.8 ETO36218.1 - 0.85 10.0 4.4 3.3 8.1 0.3 3.3 3 0 0 3 3 3 0 Mediator complex subunit 27 zinc-ribbons_6 PF07191.12 ETO36218.1 - 3.9 7.5 8.9 2 8.5 5.0 2.5 2 0 0 2 2 2 0 zinc-ribbons DUF2607 PF10795.9 ETO36219.1 - 2 8.6 4.9 1.3 9.2 1.6 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF2607) PhyH PF05721.13 ETO36220.1 - 0.00077 19.8 0.1 0.078 13.2 0.0 2.8 3 0 0 3 3 3 1 Phytanoyl-CoA dioxygenase (PhyH) APCDDC PF14921.6 ETO36220.1 - 0.0069 15.9 0.1 0.012 15.0 0.1 1.4 1 0 0 1 1 1 1 Adenomatosis polyposis coli down-regulated 1 FGF PF00167.18 ETO36220.1 - 0.066 13.3 2.6 0.1 12.7 0.3 2.4 2 1 0 2 2 2 0 Fibroblast growth factor Big_3_3 PF13750.6 ETO36220.1 - 0.073 12.7 0.0 0.15 11.7 0.0 1.5 1 0 0 1 1 1 0 Bacterial Ig-like domain (group 3) Peptidase_M61 PF05299.12 ETO36220.1 - 0.52 10.7 3.1 1.8 9.0 0.0 3.0 4 0 0 4 4 4 0 M61 glycyl aminopeptidase EF-hand_7 PF13499.6 ETO36224.1 - 1.5e-21 76.6 11.1 2.2e-11 44.0 2.4 2.3 2 0 0 2 2 2 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO36224.1 - 3.9e-18 63.6 12.3 2e-05 23.8 0.3 4.5 4 0 0 4 4 4 4 EF hand EF-hand_6 PF13405.6 ETO36224.1 - 4.7e-16 57.3 6.2 0.00019 21.1 0.0 4.6 4 0 0 4 4 4 4 EF-hand domain EF-hand_9 PF14658.6 ETO36224.1 - 1.6e-12 47.6 0.9 6.2e-05 23.2 0.0 2.3 2 0 0 2 2 2 2 EF-hand domain EF-hand_8 PF13833.6 ETO36224.1 - 7e-12 45.0 9.5 5.2e-09 35.8 1.6 2.8 2 1 0 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO36224.1 - 2.9e-05 23.4 4.8 0.21 11.2 0.0 4.5 4 0 0 4 4 4 1 EF hand SUB1_ProdP9 PF18213.1 ETO36224.1 - 0.0001 22.1 0.3 0.0001 22.1 0.3 1.8 2 0 0 2 2 2 1 SUB1 protease Prodomain ProdP9 EF-hand_14 PF17959.1 ETO36224.1 - 0.0018 18.5 6.0 0.27 11.6 0.3 2.7 1 1 1 2 2 2 2 EF-hand domain SPARC_Ca_bdg PF10591.9 ETO36224.1 - 0.014 15.7 4.3 0.47 10.8 1.0 2.3 2 0 0 2 2 2 0 Secreted protein acidic and rich in cysteine Ca binding region AAA_assoc_C PF09821.9 ETO36224.1 - 0.038 14.5 1.5 0.23 12.0 0.2 2.4 1 1 0 2 2 2 0 C-terminal AAA-associated domain UBD PF16455.5 ETO36224.1 - 0.073 13.3 0.2 0.13 12.5 0.2 1.4 1 0 0 1 1 1 0 Ubiquitin-binding domain EF-hand_4 PF12763.7 ETO36224.1 - 0.16 12.0 8.1 1.7 8.6 0.4 2.7 2 1 1 3 3 3 0 Cytoskeletal-regulatory complex EF hand DUF1002 PF06207.11 ETO36224.1 - 0.18 11.3 4.3 0.17 11.4 1.7 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1002) Takusan PF04822.13 ETO36224.1 - 0.43 10.5 7.5 1.6 8.6 7.5 2.1 1 1 0 1 1 1 0 Takusan DUF3008 PF11450.8 ETO36224.1 - 5.5 7.2 5.1 2.5 8.3 1.2 2.2 2 0 0 2 2 2 0 Protein of unknwon function (DUF3008) PH PF00169.29 ETO36225.1 - 2.4e-18 66.6 0.1 5.1e-18 65.5 0.1 1.5 1 0 0 1 1 1 1 PH domain PH_3 PF14593.6 ETO36225.1 - 2.6e-05 24.3 0.0 4.7e-05 23.4 0.0 1.4 1 0 0 1 1 1 1 PH domain PH_11 PF15413.6 ETO36225.1 - 0.00023 21.6 2.6 0.00023 21.6 2.6 2.6 2 2 0 2 2 2 1 Pleckstrin homology domain PH_8 PF15409.6 ETO36225.1 - 0.012 15.9 0.1 0.026 14.8 0.1 1.7 1 0 0 1 1 1 0 Pleckstrin homology domain DUF739 PF05339.11 ETO36226.1 - 0.05 13.7 0.1 0.14 12.3 0.1 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF739) YojJ PF10372.9 ETO36226.1 - 3.5 7.8 18.9 0.51 10.5 0.3 4.5 3 2 2 5 5 5 0 Bacterial membrane-spanning protein N-terminus RVT_1 PF00078.27 ETO36228.1 - 0.00023 20.8 0.2 0.52 9.8 0.0 2.6 1 1 1 2 2 2 2 Reverse transcriptase (RNA-dependent DNA polymerase) Ribosomal_L6e PF01159.19 ETO36229.1 - 0.29 11.7 4.0 0.81 10.3 0.7 2.4 2 1 1 3 3 3 0 Ribosomal protein L6e PrmA PF06325.13 ETO36230.1 - 6e-05 22.6 0.0 0.00011 21.8 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11 methyltransferase (PrmA) Methyltransf_23 PF13489.6 ETO36230.1 - 0.0001 22.2 0.0 0.00018 21.4 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO36230.1 - 0.0036 18.0 0.3 0.012 16.3 0.3 1.9 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO36230.1 - 0.0079 16.0 0.5 0.026 14.3 0.1 1.9 2 0 0 2 2 2 1 Methyltransferase domain Methyltransf_9 PF08003.11 ETO36230.1 - 0.064 12.2 0.0 0.096 11.6 0.0 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) Methyltransf_11 PF08241.12 ETO36230.1 - 0.069 13.8 0.1 0.17 12.5 0.1 1.7 1 0 0 1 1 1 0 Methyltransferase domain MTS PF05175.14 ETO36230.1 - 0.087 12.4 0.1 0.15 11.6 0.1 1.3 1 0 0 1 1 1 0 Methyltransferase small domain Phlebovirus_G1 PF07243.11 ETO36232.1 - 0.07 11.5 1.2 0.094 11.1 1.2 1.1 1 0 0 1 1 1 0 Phlebovirus glycoprotein G1 PHD PF00628.29 ETO36232.1 - 0.15 12.0 2.0 0.35 10.8 2.0 1.5 1 0 0 1 1 1 0 PHD-finger Toprim_C_rpt PF13368.6 ETO36232.1 - 0.2 11.6 0.1 0.63 10.1 0.0 1.8 2 0 0 2 2 2 0 Topoisomerase C-terminal repeat PTPlike_phytase PF14566.6 ETO36233.1 - 1.7e-17 63.9 0.1 6e-17 62.2 0.0 1.9 2 0 0 2 2 2 1 Inositol hexakisphosphate Cnd1_N PF12922.7 ETO36233.1 - 0.033 14.0 0.4 0.053 13.4 0.4 1.4 1 0 0 1 1 1 0 non-SMC mitotic condensation complex subunit 1, N-term WD40 PF00400.32 ETO36234.1 - 1.2e-36 124.0 15.5 1.3e-09 38.5 0.2 6.8 6 1 1 7 7 7 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36234.1 - 7.5e-17 61.4 2.7 0.00051 20.3 0.0 6.0 2 2 4 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36234.1 - 6.6e-11 41.7 0.1 0.0041 16.1 0.0 4.1 2 1 3 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO36234.1 - 1.5e-07 31.5 0.2 0.0071 16.2 0.0 3.1 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO36234.1 - 1.1e-06 28.2 1.3 0.00087 18.7 0.2 3.2 3 0 0 3 3 3 1 WD40-like domain Str_synth PF03088.16 ETO36234.1 - 1.1e-05 25.5 0.2 2.2 8.4 0.1 4.1 3 1 1 4 4 4 2 Strictosidine synthase Nup160 PF11715.8 ETO36234.1 - 5.3e-05 22.1 1.7 0.21 10.2 0.1 3.3 3 1 0 4 4 4 2 Nucleoporin Nup120/160 PD40 PF07676.12 ETO36234.1 - 0.0001 22.1 0.9 10 6.2 0.0 5.5 5 1 0 5 5 5 1 WD40-like Beta Propeller Repeat Cytochrom_D1 PF02239.16 ETO36234.1 - 0.0036 15.9 0.1 0.95 7.9 0.0 3.0 2 1 2 4 4 4 2 Cytochrome D1 heme domain NodS PF05401.11 ETO36234.1 - 0.0055 16.3 0.1 4.3 6.9 0.0 2.9 3 0 0 3 3 3 2 Nodulation protein S (NodS) B_lectin PF01453.24 ETO36234.1 - 0.022 15.3 1.5 13 6.4 0.1 3.2 2 1 1 3 3 3 0 D-mannose binding lectin Surfac_D-trimer PF09006.11 ETO36234.1 - 0.16 11.9 0.1 23 5.0 0.0 3.1 2 0 0 2 2 2 0 Lung surfactant protein D coiled-coil trimerisation Ank_5 PF13857.6 ETO36235.1 - 6.5e-10 39.1 0.2 6.2e-05 23.2 0.0 3.3 3 1 1 4 4 4 2 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO36235.1 - 4.1e-08 33.7 1.3 1.5e-07 31.9 0.2 2.5 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank PF00023.30 ETO36235.1 - 4.8e-08 33.1 0.3 7e-06 26.3 0.1 3.0 2 0 0 2 2 2 1 Ankyrin repeat Ank_4 PF13637.6 ETO36235.1 - 1.7e-07 31.6 0.1 6.2e-07 29.8 0.1 2.1 1 0 0 1 1 1 1 Ankyrin repeats (many copies) Arm PF00514.23 ETO36235.1 - 0.00012 22.0 0.5 0.028 14.5 0.1 3.1 3 0 0 3 3 3 1 Armadillo/beta-catenin-like repeat Ank_3 PF13606.6 ETO36235.1 - 0.00015 21.9 0.1 0.036 14.6 0.1 3.5 2 0 0 2 2 2 1 Ankyrin repeat PUB PF09409.10 ETO36236.1 - 0.00044 20.1 1.0 0.0073 16.2 0.1 3.1 2 0 0 2 2 2 1 PUB domain SNF5 PF04855.12 ETO36238.1 - 1.6e-12 47.7 0.4 1.9e-12 47.5 0.4 1.1 1 0 0 1 1 1 1 SNF5 / SMARCB1 / INI1 WD40 PF00400.32 ETO36240.1 - 1.4e-05 25.7 6.8 0.0027 18.5 0.1 3.7 4 0 0 4 4 4 2 WD domain, G-beta repeat SDA1 PF05285.12 ETO36241.1 - 0.0001 21.8 49.2 0.00016 21.2 49.2 1.3 1 0 0 1 1 1 1 SDA1 Peptidase_C14 PF00656.22 ETO36241.1 - 0.00015 21.8 0.0 2.3 8.1 0.0 3.5 2 2 1 3 3 3 2 Caspase domain Presenilin PF01080.17 ETO36241.1 - 0.00063 18.6 15.2 0.001 17.9 15.2 1.3 1 0 0 1 1 1 1 Presenilin CDC45 PF02724.14 ETO36241.1 - 0.00069 18.0 35.0 0.0014 17.0 35.0 1.5 1 0 0 1 1 1 1 CDC45-like protein Kelch_4 PF13418.6 ETO36241.1 - 0.083 12.9 0.2 0.3 11.1 0.1 2.0 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO36241.1 - 0.12 12.0 0.1 0.47 10.1 0.0 2.0 2 0 0 2 2 2 0 Kelch motif Zip PF02535.22 ETO36241.1 - 0.74 9.0 13.2 1.2 8.2 13.2 1.5 1 0 0 1 1 1 0 ZIP Zinc transporter DUF4045 PF13254.6 ETO36241.1 - 1.6 8.3 18.6 2.6 7.6 18.6 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4045) WD40 PF00400.32 ETO36243.1 - 1.1e-61 203.3 8.2 6.3e-09 36.3 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36243.1 - 1.7e-16 60.3 2.1 0.0041 17.4 0.0 6.2 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO36243.1 - 2e-12 47.4 3.6 1.2e-07 31.8 0.4 3.2 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO36243.1 - 2.5e-11 43.1 0.4 0.077 11.9 0.0 5.9 1 1 5 6 6 6 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36243.1 - 2.1e-07 30.6 1.5 0.0038 16.6 0.8 2.7 1 1 1 2 2 2 2 WD40-like domain Nup160 PF11715.8 ETO36243.1 - 3.3e-07 29.4 2.0 0.44 9.1 0.0 5.0 2 1 4 6 6 6 3 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO36243.1 - 9e-06 24.5 0.1 0.054 12.0 0.0 2.9 2 1 1 3 3 3 3 Cytochrome D1 heme domain Nucleoporin_N PF08801.11 ETO36243.1 - 5.5e-05 22.1 7.6 0.06 12.1 0.4 4.2 1 1 3 5 5 5 3 Nup133 N terminal like Str_synth PF03088.16 ETO36243.1 - 0.0076 16.4 0.1 2.1 8.5 0.0 3.3 3 1 1 4 4 4 1 Strictosidine synthase Frtz PF11768.8 ETO36243.1 - 0.018 13.3 0.2 0.13 10.6 0.0 2.1 1 1 3 4 4 4 0 WD repeat-containing and planar cell polarity effector protein Fritz PD40 PF07676.12 ETO36243.1 - 0.038 14.0 0.1 78 3.4 0.0 4.0 4 0 0 4 4 4 0 WD40-like Beta Propeller Repeat PALB2_WD40 PF16756.5 ETO36243.1 - 0.12 11.2 5.8 1.5 7.7 0.0 4.0 2 2 3 5 5 5 0 Partner and localizer of BRCA2 WD40 domain Ras PF00071.22 ETO36244.1 - 2.3e-32 111.8 0.0 2.7e-15 56.3 0.0 2.5 2 1 0 2 2 2 2 Ras family Roc PF08477.13 ETO36244.1 - 2.3e-09 37.5 0.0 3.4e-07 30.5 0.0 2.5 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase AAA_24 PF13479.6 ETO36244.1 - 0.061 13.0 0.1 0.13 12.0 0.0 1.5 2 0 0 2 2 2 0 AAA domain AAA_22 PF13401.6 ETO36244.1 - 0.12 12.6 0.1 1.5 9.1 0.0 2.3 2 0 0 2 2 2 0 AAA domain TFIIA PF03153.13 ETO36245.1 - 6.4e-05 23.1 15.5 0.0001 22.5 15.5 1.2 1 0 0 1 1 1 1 Transcription factor IIA, alpha/beta subunit TIMELESS_C PF05029.13 ETO36245.1 - 0.019 14.1 16.6 0.037 13.2 16.6 1.4 1 0 0 1 1 1 0 Timeless protein C terminal region SEEEED PF14797.6 ETO36245.1 - 0.11 12.6 37.8 0.2 11.8 37.8 1.3 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex YL1 PF05764.13 ETO36245.1 - 0.43 10.7 21.8 0.056 13.6 12.4 2.2 2 0 0 2 2 2 0 YL1 nuclear protein CDC45 PF02724.14 ETO36245.1 - 1.4 7.1 16.6 0.062 11.6 11.0 1.6 2 0 0 2 2 2 0 CDC45-like protein Kelch_6 PF13964.6 ETO36246.1 - 0.0019 18.4 0.3 0.015 15.6 0.0 2.5 1 1 1 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO36246.1 - 0.0051 16.8 0.2 0.015 15.3 0.0 1.9 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO36246.1 - 0.011 15.2 0.0 0.02 14.4 0.0 1.4 1 0 0 1 1 1 0 Kelch motif Kelch_6 PF13964.6 ETO36247.1 - 0.011 16.0 0.4 2.5 8.5 0.0 3.5 4 0 0 4 4 4 0 Kelch motif NACHT PF05729.12 ETO36249.1 - 0.00099 19.1 0.0 0.003 17.5 0.0 1.8 2 0 0 2 2 2 1 NACHT domain ATPase PF06745.13 ETO36249.1 - 0.016 14.5 0.8 0.47 9.7 0.0 3.0 3 0 0 3 3 3 0 KaiC AAA_18 PF13238.6 ETO36249.1 - 0.018 15.6 0.1 0.15 12.6 0.0 2.6 3 0 0 3 3 3 0 AAA domain AAA_22 PF13401.6 ETO36249.1 - 0.02 15.2 0.0 0.06 13.6 0.0 1.9 1 0 0 1 1 1 0 AAA domain RelA_SpoT PF04607.17 ETO36249.1 - 0.045 14.0 0.1 0.045 14.0 0.1 2.5 3 0 0 3 3 3 0 Region found in RelA / SpoT proteins RsgA_GTPase PF03193.16 ETO36249.1 - 0.045 13.6 0.0 0.15 11.9 0.0 1.9 1 0 0 1 1 1 0 RsgA GTPase Sigma54_activat PF00158.26 ETO36249.1 - 0.12 12.0 0.0 0.59 9.8 0.0 2.0 2 0 0 2 2 2 0 Sigma-54 interaction domain RNA_helicase PF00910.22 ETO36249.1 - 0.19 12.1 1.5 0.83 10.1 0.0 2.8 3 0 0 3 3 3 0 RNA helicase WD40 PF00400.32 ETO36250.1 - 0.0039 18.0 0.5 0.0039 18.0 0.5 2.3 3 0 0 3 3 3 1 WD domain, G-beta repeat UpxZ PF06603.11 ETO36250.1 - 0.038 14.3 0.0 0.066 13.5 0.0 1.2 1 1 0 1 1 1 0 UpxZ family of transcription anti-terminator antagonists WD40 PF00400.32 ETO36251.1 - 6.4e-06 26.8 0.5 0.00032 21.4 0.2 2.5 2 1 0 2 2 2 2 WD domain, G-beta repeat Josephin PF02099.17 ETO36252.1 - 1.3e-15 57.9 4.4 1.8e-14 54.2 4.4 2.1 1 1 0 1 1 1 1 Josephin HD_6 PF18019.1 ETO36252.1 - 0.0005 20.3 0.1 0.00071 19.8 0.1 1.1 1 0 0 1 1 1 1 HD domain CHD5 PF04420.14 ETO36252.1 - 0.21 11.4 2.2 0.31 10.9 2.2 1.4 1 1 0 1 1 1 0 CHD5-like protein zf-C2H2_6 PF13912.6 ETO36253.1 - 3.5e-05 23.7 2.7 0.00059 19.8 0.6 2.7 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO36253.1 - 0.003 17.9 6.4 0.0049 17.3 0.4 3.4 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-C2H2_4 PF13894.6 ETO36253.1 - 0.0095 16.7 5.9 0.063 14.2 0.4 3.8 3 0 0 3 3 3 1 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO36253.1 - 3.3 8.3 19.9 1 9.9 0.6 3.1 3 0 0 3 3 3 0 Zinc-finger double domain DUF2730 PF10805.8 ETO36254.1 - 0.0041 17.2 1.4 0.024 14.7 0.2 2.1 1 1 1 2 2 2 2 Protein of unknown function (DUF2730) Methyltrn_RNA_2 PF04013.12 ETO36255.1 - 0.17 11.6 0.0 0.18 11.5 0.0 1.2 1 0 0 1 1 1 0 Putative SAM-dependent RNA methyltransferase WD40 PF00400.32 ETO36256.1 - 1.6e-37 126.8 12.2 4.8e-06 27.2 0.1 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36256.1 - 4.9e-12 46.0 0.1 0.057 13.7 0.1 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36256.1 - 1.5e-05 24.2 0.0 0.065 12.2 0.0 3.2 3 0 0 3 3 3 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nucleoporin_N PF08801.11 ETO36256.1 - 0.028 13.2 0.2 0.15 10.8 0.1 2.0 2 1 1 3 3 3 0 Nup133 N terminal like Nup160 PF11715.8 ETO36256.1 - 0.11 11.1 0.0 2.3 6.7 0.0 2.6 2 1 0 2 2 2 0 Nucleoporin Nup120/160 Aminotran_4 PF01063.19 ETO36257.1 - 3.1e-24 86.1 0.0 6.7e-24 85.0 0.0 1.6 1 1 0 1 1 1 1 Amino-transferase class IV SAYSvFN PF10260.9 ETO36258.1 - 5.1e-21 74.4 2.5 7.8e-21 73.8 2.5 1.3 1 0 0 1 1 1 1 Uncharacterized conserved domain (SAYSvFN) SEC-C PF02810.15 ETO36258.1 - 2e-07 30.8 10.4 3e-07 30.2 10.4 1.3 1 0 0 1 1 1 1 SEC-C motif Kelch_4 PF13418.6 ETO36260.1 - 2.7e-06 27.3 0.5 0.008 16.2 0.0 3.2 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO36260.1 - 6.4e-06 25.9 1.0 0.013 15.4 0.1 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_6 PF13964.6 ETO36260.1 - 0.00068 19.8 3.4 3.5 8.0 0.0 4.3 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO36260.1 - 0.0012 18.8 3.6 0.75 9.9 0.6 5.0 6 0 0 6 6 6 1 Kelch motif Kelch_1 PF01344.25 ETO36260.1 - 0.014 15.0 3.7 0.028 14.0 0.1 3.3 5 0 0 5 5 5 0 Kelch motif QRPTase_N PF02749.16 ETO36261.1 - 1.1e-26 92.7 0.0 1.5e-26 92.2 0.0 1.2 1 0 0 1 1 1 1 Quinolinate phosphoribosyl transferase, N-terminal domain Biotin_lipoyl PF00364.22 ETO36261.1 - 0.021 14.7 0.0 0.055 13.3 0.0 1.8 1 0 0 1 1 1 0 Biotin-requiring enzyme PYNP_C PF07831.13 ETO36261.1 - 0.089 12.5 0.0 0.18 11.4 0.0 1.5 1 0 0 1 1 1 0 Pyrimidine nucleoside phosphorylase C-terminal domain CAF1 PF04857.20 ETO36262.1 - 0.02 14.1 1.5 0.027 13.7 1.5 1.2 1 0 0 1 1 1 0 CAF1 family ribonuclease Minor_tail_Z PF06763.11 ETO36262.1 - 0.1 12.4 3.9 0.075 12.8 2.0 1.7 3 0 0 3 3 3 0 Prophage minor tail protein Z (GPZ) DBINO PF13892.6 ETO36262.1 - 0.12 12.7 12.5 0.2 12.0 12.3 1.4 1 1 0 1 1 1 0 DNA-binding domain Clr2 PF10383.9 ETO36262.1 - 0.45 11.3 3.0 1 10.2 3.0 1.5 1 0 0 1 1 1 0 Transcription-silencing protein Clr2 VPS13_C PF16909.5 ETO36264.1 - 1.1e-60 204.5 3.1 7.6e-54 182.2 0.0 3.2 2 1 1 3 3 3 3 Vacuolar-sorting-associated 13 protein C-terminal SHR-BD PF06650.12 ETO36264.1 - 4.6e-26 91.8 0.9 1.6e-25 90.0 0.3 2.2 2 0 0 2 2 2 1 SHR-binding domain of vacuolar-sorting associated protein 13 C2 PF00168.30 ETO36264.1 - 5.6e-17 61.9 0.3 2.5e-16 59.8 0.1 2.3 2 0 0 2 2 2 1 C2 domain ATG_C PF09333.11 ETO36264.1 - 1.9e-09 37.7 2.2 2.4e-09 37.4 0.0 2.3 3 0 0 3 3 3 1 Autophagy-related protein C terminal domain MFP2b PF12150.8 ETO36264.1 - 0.091 12.1 0.1 0.45 9.8 0.0 2.0 2 0 0 2 2 2 0 Cytosolic motility protein FlxA PF14282.6 ETO36264.1 - 5.5 7.0 16.3 0.17 11.9 9.5 1.9 2 0 0 2 2 2 0 FlxA-like protein RabGAP-TBC PF00566.18 ETO36266.1 - 0.029 14.0 0.1 0.033 13.8 0.1 1.1 1 0 0 1 1 1 0 Rab-GTPase-TBC domain DUF5399 PF17377.2 ETO36266.1 - 0.88 9.4 6.0 2.1 8.2 6.0 1.7 1 1 0 1 1 1 0 Family of unknown function (DUF5399) Phage_rep_O PF04492.13 ETO36267.1 - 0.063 13.9 0.8 0.16 12.6 0.1 2.1 2 0 0 2 2 2 0 Bacteriophage replication protein O WD40 PF00400.32 ETO36269.1 - 5.4e-67 220.1 18.0 4.5e-09 36.8 1.2 7.8 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36269.1 - 2e-18 66.4 3.7 7.1e-05 23.0 0.0 6.9 3 1 5 8 8 7 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36269.1 - 2e-17 63.2 1.0 0.061 12.3 0.0 7.5 3 1 6 9 9 9 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36269.1 - 1.9e-10 40.6 4.3 0.0036 16.7 0.2 3.8 2 1 1 3 3 3 3 WD40-like domain PD40 PF07676.12 ETO36269.1 - 4.1e-05 23.4 9.4 5 7.2 0.1 5.7 6 0 0 6 6 6 1 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO36269.1 - 0.00016 21.1 1.7 1.1 8.5 0.0 4.3 3 1 1 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Kelch_4 PF13418.6 ETO36269.1 - 0.0064 16.5 1.1 0.061 13.3 0.0 2.9 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO36269.1 - 0.0084 15.7 0.6 0.038 13.6 0.2 2.3 2 0 0 2 2 2 1 Kelch motif NodS PF05401.11 ETO36269.1 - 0.0086 15.7 0.0 0.62 9.6 0.0 3.2 3 0 0 3 3 3 1 Nodulation protein S (NodS) DUF1797 PF08796.10 ETO36269.1 - 0.011 15.7 0.0 8.5 6.5 0.0 3.8 2 1 1 3 3 3 0 Protein of unknown function (DUF1797) Kelch_6 PF13964.6 ETO36269.1 - 0.025 14.8 0.8 5.6 7.4 0.1 4.1 3 0 0 3 3 3 0 Kelch motif HARP PF07443.13 ETO36269.1 - 0.028 14.1 0.8 12 5.6 0.0 4.3 5 0 0 5 5 5 0 HepA-related protein (HARP) Kelch_2 PF07646.15 ETO36269.1 - 0.1 12.6 1.0 3.4 7.8 0.0 3.8 4 0 0 4 4 4 0 Kelch motif YMF19 PF02326.15 ETO36270.1 - 0.23 12.2 0.3 0.23 12.2 0.3 4.1 2 2 3 5 5 5 0 Plant ATP synthase F0 QRPTase_C PF01729.19 ETO36271.1 - 2.2e-48 164.2 7.6 4.7e-41 140.4 2.7 2.0 1 1 1 2 2 2 2 Quinolinate phosphoribosyl transferase, C-terminal domain SAWADEE PF16719.5 ETO36271.1 - 0.072 13.1 0.1 0.12 12.4 0.1 1.3 1 0 0 1 1 1 0 SAWADEE domain WD40 PF00400.32 ETO36273.1 - 1.8e-05 25.4 0.2 0.00026 21.7 0.5 2.6 2 1 0 2 2 2 1 WD domain, G-beta repeat AlbA_2 PF04326.14 ETO36275.1 - 0.036 14.4 2.5 0.066 13.6 2.4 1.5 1 1 0 1 1 1 0 Putative DNA-binding domain ETRAMP PF09716.10 ETO36275.1 - 4.8 7.3 6.5 3.4 7.8 1.6 2.3 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) DUF446 PF04287.12 ETO36276.1 - 0.19 11.8 2.0 6.6 6.9 0.8 2.4 1 1 1 2 2 2 0 tRNA pseudouridine synthase C Secretin_N_2 PF07655.13 ETO36277.1 - 0.00093 19.7 4.1 0.0015 19.1 4.1 1.4 1 0 0 1 1 1 1 Secretin N-terminal domain zf_UBZ PF18439.1 ETO36277.1 - 0.019 14.5 3.7 0.28 10.8 0.4 2.4 2 0 0 2 2 2 0 Ubiquitin-Binding Zinc Finger Presenilin PF01080.17 ETO36277.1 - 0.14 10.9 1.4 0.12 11.1 1.4 1.1 1 0 0 1 1 1 0 Presenilin Transposase_21 PF02992.14 ETO36277.1 - 0.16 11.2 3.7 0.22 10.7 3.7 1.3 1 0 0 1 1 1 0 Transposase family tnp2 Peptidase_S49_N PF08496.10 ETO36277.1 - 0.84 9.7 3.9 1.3 9.1 3.9 1.4 1 0 0 1 1 1 0 Peptidase family S49 N-terminal Orf78 PF06024.12 ETO36277.1 - 1.8 8.9 5.8 3.1 8.2 5.8 1.4 1 0 0 1 1 1 0 Orf78 (ac78) Folate_carrier PF01770.18 ETO36277.1 - 2 7.0 3.1 2.6 6.7 3.1 1.1 1 0 0 1 1 1 0 Reduced folate carrier ALMT PF11744.8 ETO36277.1 - 2.1 7.1 4.8 2.1 7.1 4.8 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DUF2076 PF09849.9 ETO36277.1 - 2.4 8.1 8.5 3 7.8 8.5 1.1 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) Zip PF02535.22 ETO36277.1 - 5.9 6.0 4.6 5.7 6.1 4.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ceramidase PF05875.12 ETO36278.1 - 9.4e-08 31.8 28.2 9.4e-08 31.8 28.2 2.6 2 1 0 2 2 2 1 Ceramidase zf-UBR PF02207.20 ETO36279.1 - 1e-18 67.2 14.0 2.3e-18 66.1 14.0 1.7 1 0 0 1 1 1 1 Putative zinc finger in N-recognin (UBR box) DUF2014 PF09427.10 ETO36279.1 - 0.052 12.9 0.1 0.088 12.1 0.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF2014) SUIM_assoc PF16619.5 ETO36280.1 - 0.48 10.5 10.2 0.24 11.5 7.1 2.1 2 0 0 2 2 2 0 Unstructured region C-term to UIM in Ataxin3 TB2_DP1_HVA22 PF03134.19 ETO36281.1 - 3.2e-06 27.0 28.3 4.2e-06 26.6 7.8 3.8 2 1 0 2 2 2 1 TB2/DP1, HVA22 family Sprouty PF05210.13 ETO36281.1 - 1.8 9.0 7.1 2.6 8.5 0.1 3.2 3 0 0 3 3 3 0 Sprouty protein (Spry) COX2-transmemb PF09125.10 ETO36281.1 - 9.8 6.1 8.1 2.8 7.8 0.1 3.4 3 0 0 3 3 3 0 Cytochrome C oxidase subunit II, transmembrane Cytochrom_C_2 PF01322.20 ETO36282.1 - 0.0046 17.8 0.2 0.086 13.7 0.2 2.1 1 1 0 1 1 1 1 Cytochrome C' Rnk_N PF14760.6 ETO36282.1 - 0.0056 17.1 0.1 0.01 16.3 0.1 1.5 1 0 0 1 1 1 1 Rnk N-terminus Phasin PF05597.11 ETO36282.1 - 0.013 15.5 2.3 0.013 15.5 2.3 1.9 2 0 0 2 2 2 0 Poly(hydroxyalcanoate) granule associated protein (phasin) DUF5104 PF17117.5 ETO36282.1 - 0.084 13.3 4.8 0.18 12.2 4.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF5104) HhH-GPD PF00730.25 ETO36282.1 - 0.089 13.3 0.1 0.17 12.4 0.1 1.7 1 1 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein SPT16 PF08644.11 ETO36282.1 - 0.52 10.5 6.5 0.66 10.2 6.3 1.5 1 1 0 1 1 1 0 FACT complex subunit (SPT16/CDC68) BING4CT PF08149.11 ETO36282.1 - 2.7 7.9 6.2 12 5.8 0.1 2.4 2 0 0 2 2 2 0 BING4CT (NUC141) domain GAF PF01590.26 ETO36283.1 - 2e-19 70.6 0.0 1.5e-08 35.3 0.0 2.4 2 1 0 2 2 2 2 GAF domain GAF_2 PF13185.6 ETO36283.1 - 1.6e-06 28.5 0.0 0.0067 16.7 0.0 3.0 3 0 0 3 3 3 2 GAF domain GAF_3 PF13492.6 ETO36283.1 - 6.7e-05 23.2 0.0 0.89 9.9 0.0 3.2 3 0 0 3 3 3 2 GAF domain Med22 PF06179.12 ETO36284.1 - 6e-07 29.6 1.1 1.1e-06 28.8 1.1 1.5 1 1 0 1 1 1 1 Surfeit locus protein 5 subunit 22 of Mediator complex Asp-B-Hydro_N PF05279.11 ETO36285.1 - 0.061 13.4 20.0 0.068 13.2 20.0 1.1 1 0 0 1 1 1 0 Aspartyl beta-hydroxylase N-terminal region RR_TM4-6 PF06459.12 ETO36285.1 - 0.54 10.1 21.7 0.67 9.7 21.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4551 PF15087.6 ETO36285.1 - 1.2 7.8 13.0 1.4 7.7 13.0 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF4551) GAGA_bind PF06217.12 ETO36285.1 - 1.7 8.9 15.4 2.1 8.6 15.4 1.2 1 0 0 1 1 1 0 GAGA binding protein-like family PA26 PF04636.13 ETO36285.1 - 2.1 7.2 10.5 2.3 7.1 10.5 1.1 1 0 0 1 1 1 0 PA26 p53-induced protein (sestrin) ALMT PF11744.8 ETO36285.1 - 4.1 6.1 11.2 4.5 6.0 11.2 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter CDC45 PF02724.14 ETO36285.1 - 4.1 5.6 19.3 4.5 5.4 19.3 1.0 1 0 0 1 1 1 0 CDC45-like protein SLC12 PF03522.15 ETO36285.1 - 5.8 5.8 17.1 6.6 5.6 17.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 Ndc1_Nup PF09531.10 ETO36285.1 - 6.1 5.4 12.0 6.8 5.3 12.0 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup AIF_C PF14721.6 ETO36285.1 - 7.8 6.9 19.6 0.15 12.4 3.0 2.3 1 1 1 2 2 2 0 Apoptosis-inducing factor, mitochondrion-associated, C-term GCD14 PF08704.10 ETO36285.1 - 7.9 6.1 10.0 10 5.7 10.0 1.2 1 0 0 1 1 1 0 tRNA methyltransferase complex GCD14 subunit GREB1 PF15782.5 ETO36285.1 - 8.9 3.3 10.6 9.2 3.2 10.6 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Peptidase_S30 PF01577.16 ETO36285.1 - 9.6 5.7 21.2 12 5.4 21.2 1.1 1 0 0 1 1 1 0 Potyvirus P1 protease DoxA PF07680.11 ETO36286.1 - 0.14 12.0 1.5 0.17 11.7 0.1 1.8 2 0 0 2 2 2 0 TQO small subunit DoxA PUB PF09409.10 ETO36287.1 - 0.01 15.8 0.5 0.061 13.3 0.5 2.3 1 1 0 1 1 1 1 PUB domain ATP-synt_8 PF00895.20 ETO36288.1 - 9.7 6.7 8.8 4 8.0 5.0 2.5 2 0 0 2 2 2 0 ATP synthase protein 8 TPR_12 PF13424.6 ETO36289.1 - 5.4e-92 302.2 9.4 3.1e-13 49.8 0.0 9.2 5 2 3 9 9 9 8 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36289.1 - 1.3e-69 227.4 66.7 3.4e-08 33.0 1.4 13.4 13 0 0 13 13 13 13 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36289.1 - 9.9e-66 216.0 0.2 1.1e-05 25.2 0.0 13.4 14 0 0 14 14 13 12 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36289.1 - 8.1e-62 200.3 67.9 1.5e-06 28.0 0.9 14.0 14 0 0 14 14 13 12 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36289.1 - 6.3e-58 188.7 17.4 1.1e-05 25.2 0.0 13.2 13 0 0 13 13 13 11 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36289.1 - 5.2e-54 176.1 51.3 1.1e-05 25.1 0.8 12.8 12 0 0 12 12 12 11 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36289.1 - 2.7e-24 83.8 0.0 0.29 12.1 0.0 11.9 11 1 1 12 12 11 4 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36289.1 - 3.8e-19 69.0 0.0 0.034 14.8 0.0 8.5 8 3 2 10 10 9 4 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36289.1 - 1.6e-17 62.9 21.4 0.024 15.3 0.3 11.9 12 0 0 12 12 12 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO36289.1 - 2.2e-12 47.0 0.0 7.2e-05 22.3 0.0 4.3 3 1 0 4 4 4 3 MalT-like TPR region TPR_17 PF13431.6 ETO36289.1 - 4.4e-11 42.4 19.5 1.9 9.1 0.0 12.2 12 1 1 13 13 11 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36289.1 - 1.6e-07 30.8 57.6 0.46 10.2 1.9 13.4 11 3 2 13 13 13 6 TPR repeat SHNi-TPR PF10516.9 ETO36289.1 - 4.7e-06 26.0 10.0 0.19 11.2 0.0 7.5 9 0 0 9 9 7 1 SHNi-TPR TPR_19 PF14559.6 ETO36289.1 - 0.00016 22.2 13.9 0.13 12.7 1.7 6.2 5 1 4 9 9 7 1 Tetratricopeptide repeat Kelch_5 PF13854.6 ETO36289.1 - 0.00028 20.8 1.5 0.2 11.7 0.0 3.2 3 0 0 3 3 2 1 Kelch motif DUF5113 PF17140.4 ETO36289.1 - 0.0025 17.6 38.3 2.4 7.9 0.0 10.8 12 1 1 13 13 11 1 Domain of unknown function (DUF5113) Kelch_3 PF13415.6 ETO36289.1 - 0.0026 18.0 0.0 0.0083 16.4 0.0 1.8 1 0 0 1 1 1 1 Galactose oxidase, central domain MIT PF04212.18 ETO36289.1 - 0.011 15.8 39.7 1.4 9.0 0.1 9.3 9 1 1 10 10 9 0 MIT (microtubule interacting and transport) domain Peptidase_C14 PF00656.22 ETO36289.1 - 0.012 15.6 0.5 0.05 13.6 0.1 2.1 2 0 0 2 2 2 0 Caspase domain Kelch_6 PF13964.6 ETO36289.1 - 0.014 15.7 8.0 5.4 7.4 0.1 4.8 5 0 0 5 5 4 0 Kelch motif DUF4810 PF16068.5 ETO36289.1 - 0.014 15.9 7.8 17 6.0 0.0 6.4 7 1 0 7 7 6 0 Domain of unknown function (DUF4810) SPO22 PF08631.10 ETO36289.1 - 0.037 13.5 10.6 9.6 5.6 0.1 4.8 3 2 1 4 4 4 0 Meiosis protein SPO22/ZIP4 like DUF1120 PF06551.12 ETO36289.1 - 0.054 13.7 0.2 0.43 10.8 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF1120) PPR PF01535.20 ETO36289.1 - 0.22 11.8 26.3 6.1 7.3 0.1 9.1 11 0 0 11 11 8 0 PPR repeat TPR_21 PF09976.9 ETO36289.1 - 0.25 11.0 6.2 22 4.7 0.0 5.3 4 1 2 6 6 6 0 Tetratricopeptide repeat-like domain Mob_Pre PF01076.19 ETO36289.1 - 0.27 11.0 15.0 0.049 13.4 0.9 4.6 2 1 3 5 5 5 0 Plasmid recombination enzyme Sel1 PF08238.12 ETO36289.1 - 0.63 10.8 32.2 18 6.2 0.0 9.9 11 0 0 11 11 10 0 Sel1 repeat Kelch_1 PF01344.25 ETO36289.1 - 0.91 9.2 2.7 1 9.0 0.4 2.4 2 0 0 2 2 2 0 Kelch motif FAT PF02259.23 ETO36289.1 - 1.4 8.0 7.4 1.2 8.3 0.6 3.0 3 0 0 3 3 3 0 FAT domain ANAPC3 PF12895.7 ETO36289.1 - 3.5 7.9 28.0 7.5 6.9 0.1 6.6 3 1 4 8 8 7 0 Anaphase-promoting complex, cyclosome, subunit 3 WD40 PF00400.32 ETO36290.1 - 1.7e-121 392.6 53.4 1.8e-09 38.0 0.6 16.1 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36290.1 - 1.4e-29 102.3 22.4 0.0065 16.7 0.1 12.8 1 1 15 16 16 16 9 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36290.1 - 1.9e-17 63.5 14.7 0.0011 18.4 0.0 6.4 2 2 5 7 7 7 5 WD40-like domain Ge1_WD40 PF16529.5 ETO36290.1 - 1.7e-16 60.1 2.9 0.0012 17.8 0.0 10.6 1 1 10 11 11 11 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO36290.1 - 8.2e-14 51.1 33.9 0.0075 15.0 0.1 13.6 2 2 11 15 15 15 6 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO36290.1 - 3.4e-06 27.1 0.3 12 6.1 0.0 5.9 5 1 1 6 6 6 2 Strictosidine synthase DUF5570 PF17731.1 ETO36290.1 - 0.00035 20.7 13.9 2.9 8.0 0.0 8.7 5 5 5 11 11 11 1 Family of unknown function (DUF5570) SGL PF08450.12 ETO36290.1 - 0.0005 19.7 3.5 19 4.7 0.0 5.2 3 1 2 5 5 5 0 SMP-30/Gluconolactonase/LRE-like region DUF727 PF05303.12 ETO36290.1 - 0.00094 19.2 2.2 19 5.4 0.0 6.3 6 2 2 8 8 8 0 Protein of unknown function (DUF727) PD40 PF07676.12 ETO36290.1 - 0.003 17.5 12.6 12 5.9 0.0 8.0 9 0 0 9 9 9 1 WD40-like Beta Propeller Repeat Mid2 PF04478.12 ETO36290.1 - 0.017 15.0 13.1 28 4.5 0.1 7.7 4 4 5 9 9 9 0 Mid2 like cell wall stress sensor DUF3475 PF11961.8 ETO36290.1 - 0.089 12.9 6.1 44 4.3 0.0 6.2 8 0 0 8 8 8 0 Domain of unknown function (DUF3475) Peptidase_C14 PF00656.22 ETO36291.1 - 0.028 14.4 0.1 0.04 13.9 0.1 1.4 1 1 0 1 1 1 0 Caspase domain NACHT PF05729.12 ETO36292.1 - 7.9e-09 35.6 0.0 1.1e-08 35.2 0.0 1.2 1 0 0 1 1 1 1 NACHT domain AAA_18 PF13238.6 ETO36292.1 - 7.3e-06 26.5 0.0 1.3e-05 25.7 0.0 1.4 1 0 0 1 1 1 1 AAA domain AAA_22 PF13401.6 ETO36292.1 - 3.5e-05 24.1 0.1 0.00013 22.3 0.1 1.7 1 1 0 1 1 1 1 AAA domain TsaE PF02367.17 ETO36292.1 - 0.0002 21.4 0.1 0.00057 19.9 0.0 1.8 2 0 0 2 2 2 1 Threonylcarbamoyl adenosine biosynthesis protein TsaE ABC_tran PF00005.27 ETO36292.1 - 0.0024 18.4 0.1 0.0035 17.9 0.1 1.3 1 1 0 1 1 1 1 ABC transporter RNA_helicase PF00910.22 ETO36292.1 - 0.0025 18.2 0.3 0.0068 16.8 0.3 1.8 1 1 0 1 1 1 1 RNA helicase RsgA_GTPase PF03193.16 ETO36292.1 - 0.003 17.5 0.5 0.011 15.6 0.1 1.9 1 1 0 2 2 2 1 RsgA GTPase AAA_17 PF13207.6 ETO36292.1 - 0.0044 17.4 0.0 0.0078 16.6 0.0 1.5 1 0 0 1 1 1 1 AAA domain ATP_bind_2 PF03668.15 ETO36292.1 - 0.0068 15.7 0.0 0.0081 15.5 0.0 1.1 1 0 0 1 1 1 1 P-loop ATPase protein family AAA_16 PF13191.6 ETO36292.1 - 0.012 16.0 0.1 0.092 13.1 0.1 2.0 1 1 0 1 1 1 0 AAA ATPase domain AAA_30 PF13604.6 ETO36292.1 - 0.017 14.8 0.0 0.021 14.6 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_33 PF13671.6 ETO36292.1 - 0.019 15.1 0.0 0.03 14.5 0.0 1.5 1 1 0 1 1 1 0 AAA domain AAA PF00004.29 ETO36292.1 - 0.023 15.1 0.0 0.032 14.7 0.0 1.3 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) KAP_NTPase PF07693.14 ETO36292.1 - 0.026 13.8 0.2 0.13 11.4 0.0 1.8 1 1 1 2 2 2 0 KAP family P-loop domain Cytidylate_kin PF02224.18 ETO36292.1 - 0.029 14.1 0.0 0.04 13.6 0.0 1.2 1 0 0 1 1 1 0 Cytidylate kinase AAA_5 PF07728.14 ETO36292.1 - 0.033 14.2 0.0 0.062 13.3 0.0 1.6 1 1 0 1 1 1 0 AAA domain (dynein-related subfamily) Zeta_toxin PF06414.12 ETO36292.1 - 0.037 13.3 0.1 0.051 12.9 0.1 1.4 1 1 0 1 1 1 0 Zeta toxin Sigma54_activat PF00158.26 ETO36292.1 - 0.048 13.4 0.1 0.072 12.8 0.0 1.3 1 1 0 1 1 1 0 Sigma-54 interaction domain AAA_21 PF13304.6 ETO36292.1 - 0.049 13.4 0.2 0.074 12.8 0.2 1.3 1 1 0 1 1 1 0 AAA domain, putative AbiEii toxin, Type IV TA system PRK PF00485.18 ETO36292.1 - 0.049 13.4 0.0 0.059 13.1 0.0 1.4 1 1 0 1 1 1 0 Phosphoribulokinase / Uridine kinase family ATPase PF06745.13 ETO36292.1 - 0.058 12.7 0.4 0.46 9.8 0.0 2.0 1 1 1 2 2 2 0 KaiC AAA_24 PF13479.6 ETO36292.1 - 0.064 13.0 0.0 0.13 12.0 0.0 1.7 1 1 0 1 1 1 0 AAA domain NB-ARC PF00931.22 ETO36292.1 - 0.1 11.7 1.4 0.41 9.8 1.4 1.9 1 1 0 1 1 1 0 NB-ARC domain WD40 PF00400.32 ETO36293.1 - 1.4e-05 25.7 0.0 4.3e-05 24.2 0.0 1.9 1 0 0 1 1 1 1 WD domain, G-beta repeat DOT1 PF08123.13 ETO36293.1 - 0.072 12.6 0.8 0.1 12.1 0.8 1.3 1 0 0 1 1 1 0 Histone methylation protein DOT1 DUF3870 PF12986.7 ETO36293.1 - 0.093 13.0 0.4 0.27 11.5 0.2 1.8 1 1 1 2 2 2 0 Domain of unknown function (DUF3870) DUF4375 PF14300.6 ETO36293.1 - 0.29 11.4 3.8 0.58 10.4 0.1 2.5 2 0 0 2 2 2 0 Domain of unknown function (DUF4375) RNase_PH PF01138.21 ETO36294.1 - 3.4e-22 79.3 0.1 6.5e-22 78.4 0.1 1.5 1 0 0 1 1 1 1 3' exoribonuclease family, domain 1 Terpene_synth PF01397.21 ETO36294.1 - 0.033 13.9 1.2 0.17 11.6 0.1 2.0 2 0 0 2 2 2 0 Terpene synthase, N-terminal domain Aminotran_1_2 PF00155.21 ETO36296.1 - 3.3e-08 33.1 0.0 3.7e-08 33.0 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class I and II Jiraiya PF15038.6 ETO36296.1 - 0.017 14.5 0.1 0.027 13.9 0.1 1.2 1 0 0 1 1 1 0 Jiraiya DUF4248 PF14053.6 ETO36296.1 - 0.12 12.5 0.1 0.98 9.5 0.0 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4248) Ribosomal_S21 PF01165.20 ETO36296.1 - 0.25 11.1 2.1 3.4 7.5 0.2 2.2 2 0 0 2 2 2 0 Ribosomal protein S21 CAP PF00188.26 ETO36297.1 - 3.2e-05 24.7 0.5 5.5e-05 24.0 0.5 1.4 1 0 0 1 1 1 1 Cysteine-rich secretory protein family LURAP PF14854.6 ETO36298.1 - 0.14 12.1 1.8 0.16 11.9 1.1 1.5 1 1 0 1 1 1 0 Leucine rich adaptor protein Band_3_cyto PF07565.13 ETO36298.1 - 1.2 8.9 10.6 1.4 8.6 10.6 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain WDCP PF15390.6 ETO36298.1 - 2 6.7 9.9 2.2 6.5 9.9 1.1 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Zip PF02535.22 ETO36298.1 - 6.2 5.9 5.1 6.5 5.9 5.1 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Ras PF00071.22 ETO36299.1 - 1.9e-56 190.1 0.2 2.4e-56 189.8 0.2 1.1 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO36299.1 - 5.3e-31 107.3 0.3 1.7e-30 105.7 0.1 1.8 2 0 0 2 2 2 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO36299.1 - 4.7e-18 65.2 0.0 6.2e-18 64.9 0.0 1.1 1 0 0 1 1 1 1 ADP-ribosylation factor family MMR_HSR1 PF01926.23 ETO36299.1 - 3.5e-07 30.3 0.1 1.1e-06 28.7 0.0 1.7 2 0 0 2 2 2 1 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO36299.1 - 1.1e-06 28.2 0.0 2.2e-06 27.2 0.0 1.4 1 1 0 1 1 1 1 Gtr1/RagA G protein conserved region RsgA_GTPase PF03193.16 ETO36299.1 - 6.6e-05 22.9 0.0 0.055 13.4 0.0 2.3 2 0 0 2 2 2 2 RsgA GTPase AAA_16 PF13191.6 ETO36299.1 - 0.00017 22.0 0.0 0.00027 21.4 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain GTP_EFTU PF00009.27 ETO36299.1 - 0.00041 19.9 0.1 0.0054 16.3 0.1 2.1 1 1 0 1 1 1 1 Elongation factor Tu GTP binding domain AAA_22 PF13401.6 ETO36299.1 - 0.011 16.1 0.0 0.019 15.2 0.0 1.6 1 1 0 1 1 1 0 AAA domain SRPRB PF09439.10 ETO36299.1 - 0.023 14.2 0.0 0.036 13.5 0.0 1.3 1 0 0 1 1 1 0 Signal recognition particle receptor beta subunit Septin PF00735.18 ETO36299.1 - 0.04 13.2 0.2 0.077 12.3 0.1 1.5 2 0 0 2 2 2 0 Septin AAA_24 PF13479.6 ETO36299.1 - 0.044 13.5 0.1 0.13 12.0 0.1 1.8 1 1 0 1 1 1 0 AAA domain MCM PF00493.23 ETO36299.1 - 0.056 12.5 0.0 0.082 12.0 0.0 1.2 1 0 0 1 1 1 0 MCM P-loop domain NACHT PF05729.12 ETO36299.1 - 0.072 13.0 0.1 0.13 12.2 0.1 1.4 1 0 0 1 1 1 0 NACHT domain Phage_TTP_12 PF16461.5 ETO36300.1 - 0.12 12.1 0.0 0.24 11.1 0.0 1.6 2 0 0 2 2 2 0 Lambda phage tail tube protein, TTP CDC45 PF02724.14 ETO36301.1 - 0.79 7.9 15.2 0.88 7.8 15.2 1.0 1 0 0 1 1 1 0 CDC45-like protein Mpp10 PF04006.12 ETO36301.1 - 0.83 8.0 18.3 0.91 7.9 18.3 1.0 1 0 0 1 1 1 0 Mpp10 protein Apt1 PF10351.9 ETO36301.1 - 0.87 8.4 10.2 0.92 8.3 10.2 1.0 1 0 0 1 1 1 0 Golgi-body localisation protein domain SDA1 PF05285.12 ETO36301.1 - 0.88 8.9 17.4 1 8.7 17.4 1.1 1 0 0 1 1 1 0 SDA1 Nop14 PF04147.12 ETO36301.1 - 2.3 6.3 17.7 2.5 6.2 17.7 1.0 1 0 0 1 1 1 0 Nop14-like family Raftlin PF15250.6 ETO36301.1 - 2.6 6.7 9.2 2.7 6.7 9.2 1.1 1 0 0 1 1 1 0 Raftlin LAP1C PF05609.12 ETO36301.1 - 5.4 6.0 10.8 6 5.8 10.8 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) RR_TM4-6 PF06459.12 ETO36301.1 - 6.9 6.4 12.5 8.1 6.2 12.5 1.1 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 DUF4746 PF15928.5 ETO36301.1 - 8 5.8 10.8 9.7 5.5 10.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) Alpha-mann_mid PF09261.11 ETO36302.1 - 0.18 12.0 3.1 0.61 10.3 0.3 3.2 3 0 0 3 3 3 0 Alpha mannosidase middle domain Tox-REase-7 PF15649.6 ETO36302.1 - 1 9.7 8.3 0.29 11.5 0.8 3.6 2 1 1 3 3 3 0 Restriction endonuclease fold toxin 7 VPS9 PF02204.18 ETO36302.1 - 4.9 7.4 8.1 0.41 10.9 1.5 2.6 3 0 0 3 3 3 0 Vacuolar sorting protein 9 (VPS9) domain GAS PF13851.6 ETO36304.1 - 0.00047 19.6 19.2 0.00047 19.6 19.2 8.8 3 2 5 8 8 8 4 Growth-arrest specific micro-tubule binding TRAF_BIRC3_bd PF16673.5 ETO36304.1 - 0.035 13.9 0.4 0.035 13.9 0.4 9.3 9 1 2 11 11 11 0 TNF receptor-associated factor BIRC3 binding domain RGS PF00615.19 ETO36305.1 - 2.3e-05 24.7 7.3 0.00011 22.4 0.7 3.1 3 0 0 3 3 3 2 Regulator of G protein signaling domain TRAPP PF04051.16 ETO36306.1 - 1.8e-27 95.8 0.2 2.2e-27 95.6 0.2 1.1 1 0 0 1 1 1 1 Transport protein particle (TRAPP) component DUF4208 PF13907.6 ETO36306.1 - 0.031 14.7 0.3 0.063 13.7 0.3 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4208) Peptidase_C2 PF00648.21 ETO36307.1 - 1.5e-73 247.4 0.1 2e-73 247.0 0.1 1.2 1 0 0 1 1 1 1 Calpain family cysteine protease V-SNARE PF05008.15 ETO36308.1 - 0.0066 16.8 7.3 0.83 10.1 0.1 3.0 1 1 1 2 2 2 2 Vesicle transport v-SNARE protein N-terminus TMPIT PF07851.13 ETO36308.1 - 0.01 15.1 5.2 0.012 14.9 5.2 1.2 1 0 0 1 1 1 0 TMPIT-like protein Pox_polyA_pol PF03296.13 ETO36308.1 - 0.021 14.7 1.3 0.029 14.3 1.0 1.4 1 1 0 1 1 1 0 Poxvirus poly(A) polymerase nucleotidyltransferase domain FAM184 PF15665.5 ETO36308.1 - 0.076 12.8 11.5 0.018 14.8 8.7 1.4 2 0 0 2 2 2 0 Family with sequence similarity 184, A and B Exonuc_VII_L PF02601.15 ETO36308.1 - 0.14 11.7 3.9 0.17 11.4 3.9 1.1 1 0 0 1 1 1 0 Exonuclease VII, large subunit DUF2203 PF09969.9 ETO36308.1 - 0.19 12.5 5.9 0.29 11.9 3.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein (DUF2203) DUF2730 PF10805.8 ETO36308.1 - 0.21 11.7 5.0 0.57 10.3 0.3 2.6 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) THOC7 PF05615.13 ETO36308.1 - 0.36 11.1 9.2 1.2 9.4 9.2 1.9 1 1 0 1 1 1 0 Tho complex subunit 7 Y_phosphatase2 PF03162.13 ETO36309.1 - 1.3e-08 34.6 0.6 8.9e-08 31.9 0.6 2.5 1 0 0 1 1 1 1 Tyrosine phosphatase family DSPc PF00782.20 ETO36309.1 - 1.4e-06 28.1 0.1 1.4e-06 28.1 0.1 5.0 5 0 0 5 5 5 1 Dual specificity phosphatase, catalytic domain Y_phosphatase3 PF13350.6 ETO36309.1 - 0.00053 20.0 0.0 0.0019 18.2 0.0 1.9 1 1 0 1 1 1 1 Tyrosine phosphatase family SR-25 PF10500.9 ETO36310.1 - 0.0033 17.1 6.9 0.0033 17.1 6.9 1.8 2 0 0 2 2 2 1 Nuclear RNA-splicing-associated protein Stc1 PF12898.7 ETO36313.1 - 0.029 14.9 1.3 0.095 13.3 1.3 2.0 1 0 0 1 1 1 0 Stc1 domain BTB PF00651.31 ETO36313.1 - 0.5 10.6 2.5 0.62 10.3 0.0 2.5 3 0 0 3 3 3 0 BTB/POZ domain DUF604 PF04646.12 ETO36315.1 - 0.25 10.7 7.8 0.079 12.3 3.5 1.8 1 1 1 2 2 2 0 Protein of unknown function, DUF604 Kelch_6 PF13964.6 ETO36316.1 - 0.0002 21.5 0.4 0.00051 20.2 0.1 1.9 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO36316.1 - 0.0019 18.2 0.1 0.0056 16.6 0.1 1.8 1 0 0 1 1 1 1 Kelch motif Kelch_2 PF07646.15 ETO36316.1 - 0.04 13.9 0.1 0.083 12.9 0.1 1.5 1 0 0 1 1 1 0 Kelch motif Ras PF00071.22 ETO36317.1 - 3.1e-21 75.7 0.3 4.1e-21 75.3 0.3 1.2 1 0 0 1 1 1 1 Ras family RsgA_GTPase PF03193.16 ETO36317.1 - 0.015 15.2 0.1 0.021 14.7 0.1 1.3 1 0 0 1 1 1 0 RsgA GTPase Roc PF08477.13 ETO36317.1 - 0.016 15.5 0.2 0.033 14.4 0.0 1.7 2 1 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase RNA_pol_Rpb4 PF03874.16 ETO36317.1 - 0.065 13.6 0.3 0.32 11.3 0.3 1.9 1 1 0 1 1 1 0 RNA polymerase Rpb4 NanE PF04131.14 ETO36317.1 - 0.1 11.8 0.1 0.12 11.6 0.1 1.1 1 0 0 1 1 1 0 Putative N-acetylmannosamine-6-phosphate epimerase DUF3482 PF11981.8 ETO36318.1 - 0.28 10.6 0.0 0.39 10.1 0.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3482) DUF900 PF05990.12 ETO36319.1 - 1.7e-08 34.3 0.1 4.6e-07 29.6 0.0 2.2 2 0 0 2 2 2 1 Alpha/beta hydrolase of unknown function (DUF900) Zip PF02535.22 ETO36319.1 - 0.0066 15.7 2.9 0.0075 15.5 0.8 1.9 2 0 0 2 2 2 1 ZIP Zinc transporter Sigma_reg_N PF13800.6 ETO36319.1 - 0.052 13.8 0.1 0.18 12.1 0.1 1.9 1 0 0 1 1 1 0 Sigma factor regulator N-terminal RP-C_C PF11800.8 ETO36319.1 - 0.57 10.3 3.0 0.96 9.5 3.0 1.3 1 0 0 1 1 1 0 Replication protein C C-terminal region Presenilin PF01080.17 ETO36319.1 - 1 8.1 4.6 2.4 6.8 4.6 1.6 1 0 0 1 1 1 0 Presenilin RPN2_C PF18004.1 ETO36319.1 - 1.3 8.9 11.5 0.98 9.3 6.9 2.2 2 0 0 2 2 2 0 26S proteasome regulatory subunit RPN2 C-terminal domain PalH PF08733.10 ETO36319.1 - 1.4 7.8 7.2 0.41 9.6 0.9 2.2 2 0 0 2 2 2 0 PalH/RIM21 Asp_Arg_Hydrox PF05118.15 ETO36320.1 - 2.7e-13 50.0 0.8 2.5e-12 46.9 0.0 2.2 2 0 0 2 2 2 1 Aspartyl/Asparaginyl beta-hydroxylase PhoPQ_related PF10142.9 ETO36321.1 - 2.3e-20 72.6 0.0 2.6e-20 72.4 0.0 1.1 1 0 0 1 1 1 1 PhoPQ-activated pathogenicity-related protein Peptidase_C15 PF01470.17 ETO36322.1 - 4.7e-18 66.1 0.1 6.9e-14 52.5 0.0 2.1 1 1 1 2 2 2 2 Pyroglutamyl peptidase Mtc PF03820.17 ETO36323.1 - 4.4e-75 252.6 0.6 1.5e-74 250.9 0.6 1.7 1 1 0 1 1 1 1 Tricarboxylate carrier Csa1 PF06023.12 ETO36324.1 - 0.017 14.5 0.1 0.031 13.6 0.1 1.3 1 0 0 1 1 1 0 CRISPR-associated exonuclease Csa1 Syntaxin-18_N PF10496.9 ETO36324.1 - 0.05 13.9 1.2 0.11 12.7 0.4 2.0 2 0 0 2 2 2 0 SNARE-complex protein Syntaxin-18 N-terminus Perilipin PF03036.16 ETO36326.1 - 0.0031 16.6 2.9 0.0037 16.3 2.9 1.1 1 0 0 1 1 1 1 Perilipin family Adaptin_binding PF10199.9 ETO36326.1 - 0.0088 16.6 2.0 0.011 16.3 2.0 1.3 1 0 0 1 1 1 1 Alpha and gamma adaptin binding protein p34 Mif2_N PF15624.6 ETO36326.1 - 0.04 14.6 0.9 0.059 14.1 0.9 1.2 1 0 0 1 1 1 0 Kinetochore CENP-C fungal homologue, Mif2, N-terminal PPR PF01535.20 ETO36327.1 - 0.095 13.0 10.1 0.8 10.1 0.2 4.4 5 0 0 5 5 5 0 PPR repeat DUF4834 PF16118.5 ETO36327.1 - 0.57 11.2 3.3 16 6.5 0.8 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ppx-GppA PF02541.16 ETO36329.1 - 0.023 14.1 1.2 0.13 11.7 1.2 1.9 1 1 0 1 1 1 0 Ppx/GppA phosphatase family TPR_12 PF13424.6 ETO36331.1 - 1.5e-11 44.4 0.1 5e-11 42.7 0.1 1.9 2 0 0 2 2 2 1 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36331.1 - 4e-07 29.7 7.4 1.5e-05 24.9 0.2 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36331.1 - 0.00011 22.0 0.3 0.00078 19.3 0.0 2.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36331.1 - 0.00048 19.9 0.1 0.02 14.8 0.0 2.9 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36331.1 - 0.0019 17.9 0.6 0.0019 17.9 0.6 3.9 3 1 0 3 3 3 1 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36331.1 - 0.01 15.9 5.6 0.015 15.4 0.2 3.2 3 1 0 3 3 3 0 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36331.1 - 0.075 13.4 0.6 0.67 10.5 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36331.1 - 0.081 13.8 0.1 1.8 9.6 0.0 2.5 1 1 1 2 2 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36331.1 - 0.13 13.0 0.5 0.96 10.2 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_12 PF13424.6 ETO36332.1 - 1.1e-89 294.8 15.3 5e-21 74.8 0.1 6.5 5 2 2 7 7 7 7 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36332.1 - 8.2e-75 244.9 5.0 1e-08 34.8 0.1 10.5 11 0 0 11 11 11 9 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36332.1 - 3e-71 232.5 52.4 4.8e-09 35.7 0.5 10.1 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36332.1 - 2.2e-66 215.1 14.9 1.2e-09 37.5 0.0 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36332.1 - 9.6e-60 193.9 51.4 1.2e-06 28.3 3.0 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36332.1 - 1.1e-49 162.6 44.8 7.3e-06 25.7 2.4 10.2 10 0 0 10 10 10 10 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36332.1 - 1.2e-25 88.0 0.0 0.63 11.0 0.0 10.1 10 0 0 10 10 10 5 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36332.1 - 1.6e-23 81.3 20.2 0.011 16.0 0.0 10.8 10 2 0 10 10 10 6 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36332.1 - 5.8e-22 77.1 54.6 8.3e-05 22.2 1.0 13.1 9 6 6 15 15 15 7 TPR repeat TPR_6 PF13174.6 ETO36332.1 - 1.8e-20 72.2 17.4 0.035 14.8 0.5 9.9 10 0 0 10 10 10 6 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36332.1 - 7.3e-18 64.9 0.6 0.0022 18.6 0.4 6.8 3 2 4 7 7 7 5 Tetratricopeptide repeat TPR_3 PF07720.12 ETO36332.1 - 2.5e-16 59.3 43.6 0.00014 21.8 2.6 10.0 10 0 0 10 10 10 5 Tetratricopeptide repeat DUF5113 PF17140.4 ETO36332.1 - 1.6e-10 41.0 26.6 0.37 10.6 0.3 9.1 7 2 2 9 9 9 3 Domain of unknown function (DUF5113) TPR_MalT PF17874.1 ETO36332.1 - 3.9e-10 39.6 0.0 0.005 16.3 0.0 3.7 1 1 3 4 4 4 4 MalT-like TPR region MIT PF04212.18 ETO36332.1 - 3.6e-09 36.6 33.4 0.093 12.8 0.0 9.8 8 1 2 10 10 10 3 MIT (microtubule interacting and transport) domain SHNi-TPR PF10516.9 ETO36332.1 - 4.4e-09 35.6 6.2 1.8 8.1 0.0 8.0 9 0 0 9 9 9 2 SHNi-TPR TPR_19 PF14559.6 ETO36332.1 - 3.1e-08 34.0 7.2 0.58 10.7 0.0 6.2 2 2 3 6 6 6 2 Tetratricopeptide repeat DUF2225 PF09986.9 ETO36332.1 - 3e-07 30.4 19.5 0.019 14.7 0.2 5.0 1 1 4 5 5 5 4 Uncharacterized protein conserved in bacteria (DUF2225) ANAPC3 PF12895.7 ETO36332.1 - 1.1e-06 28.7 22.7 0.17 12.1 0.1 6.8 3 3 4 7 7 7 3 Anaphase-promoting complex, cyclosome, subunit 3 TPR_9 PF13371.6 ETO36332.1 - 3.5e-06 27.1 0.0 30 4.9 0.0 6.2 6 1 1 7 7 7 0 Tetratricopeptide repeat PPR PF01535.20 ETO36332.1 - 6.2e-06 26.1 7.7 18 5.9 0.0 7.8 8 0 0 8 8 8 0 PPR repeat DUF627 PF04781.12 ETO36332.1 - 5.6e-05 23.1 6.1 0.23 11.5 0.1 4.3 4 0 0 4 4 4 2 Protein of unknown function (DUF627) RPN7 PF10602.9 ETO36332.1 - 0.0011 18.7 21.3 2.8 7.6 0.1 7.8 4 3 3 8 8 8 1 26S proteasome subunit RPN7 DUF5475 PF17569.2 ETO36332.1 - 0.0014 18.9 0.2 16 5.9 0.0 4.7 3 2 1 4 4 3 0 Family of unknown function (DUF5475) TPR_5 PF12688.7 ETO36332.1 - 0.0018 18.5 1.8 10 6.4 0.0 5.9 5 2 2 7 7 7 0 Tetratrico peptide repeat Sel1 PF08238.12 ETO36332.1 - 0.0028 18.3 20.6 15 6.5 0.2 8.4 8 0 0 8 8 8 0 Sel1 repeat TBK1_CCD1 PF18394.1 ETO36332.1 - 0.0087 15.6 0.3 4.1 6.9 0.0 3.2 3 1 1 4 4 4 1 TANK-binding kinase 1 coiled-coil domain 1 DUF4810 PF16068.5 ETO36332.1 - 0.0095 16.5 14.6 14 6.3 0.1 7.0 6 2 1 8 8 7 0 Domain of unknown function (DUF4810) OEP PF02321.18 ETO36332.1 - 0.029 14.2 3.7 0.38 10.5 0.3 3.1 3 1 1 4 4 4 0 Outer membrane efflux protein NRBF2_MIT PF17169.4 ETO36332.1 - 0.034 14.4 2.9 25 5.2 0.0 5.2 7 0 0 7 7 5 0 MIT domain of nuclear receptor-binding factor 2 HTH_Bact PF18768.1 ETO36332.1 - 0.057 13.0 10.4 72 3.1 0.1 7.2 8 0 0 8 8 8 0 Helix-turn-helix bacterial domain SPO22 PF08631.10 ETO36332.1 - 0.082 12.4 8.3 3.1 7.2 0.2 4.5 5 2 0 5 5 5 0 Meiosis protein SPO22/ZIP4 like NTP_transf_9 PF04248.12 ETO36332.1 - 0.088 12.7 1.7 11 6.0 0.1 3.1 2 1 0 2 2 2 0 Domain of unknown function (DUF427) Pkinase PF00069.25 ETO36333.1 - 1.3e-10 41.1 0.4 2.1e-10 40.4 0.4 1.2 1 0 0 1 1 1 1 Protein kinase domain Kdo PF06293.14 ETO36333.1 - 2.6e-09 36.8 0.1 6.5e-09 35.4 0.1 1.6 1 1 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family RIO1 PF01163.22 ETO36333.1 - 1.8e-07 30.9 0.1 3.5e-07 30.0 0.1 1.5 1 0 0 1 1 1 1 RIO1 family APH PF01636.23 ETO36333.1 - 2.4e-07 30.9 0.0 1.3e-05 25.2 0.0 2.2 1 1 1 2 2 2 1 Phosphotransferase enzyme family Pkinase_Tyr PF07714.17 ETO36333.1 - 1.9e-06 27.4 0.1 3.1e-06 26.7 0.1 1.3 1 0 0 1 1 1 1 Protein tyrosine kinase EcKinase PF02958.20 ETO36333.1 - 1.4e-05 24.5 0.0 2.2e-05 23.9 0.0 1.4 1 0 0 1 1 1 1 Ecdysteroid kinase Choline_kinase PF01633.20 ETO36333.1 - 1.6e-05 24.6 0.6 4.7e-05 23.1 0.6 1.8 1 1 0 1 1 1 1 Choline/ethanolamine kinase DUF1679 PF07914.11 ETO36333.1 - 0.026 13.4 0.0 0.057 12.3 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1679) RE_Alw26IDE PF09665.10 ETO36333.1 - 0.039 13.1 0.0 0.074 12.2 0.0 1.4 1 0 0 1 1 1 0 Type II restriction endonuclease (RE_Alw26IDE) UNC80 PF15778.5 ETO36333.1 - 0.052 13.2 0.1 0.089 12.4 0.1 1.4 1 0 0 1 1 1 0 Cation channel complex component UNC80 Brix PF04427.18 ETO36334.1 - 3.1e-21 76.4 1.4 5.2e-21 75.6 1.4 1.4 1 0 0 1 1 1 1 Brix domain DAGK_acc PF00609.19 ETO36335.1 - 0.072 13.4 1.0 0.11 12.8 0.8 1.4 1 1 0 1 1 1 0 Diacylglycerol kinase accessory domain TPR_12 PF13424.6 ETO36336.1 - 1.9e-72 239.5 28.2 6.7e-19 68.0 0.9 6.5 2 2 4 7 7 7 7 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36336.1 - 1.4e-49 163.9 54.9 5e-08 32.4 1.6 10.6 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36336.1 - 3e-44 147.7 10.7 6.4e-08 32.2 0.0 9.0 10 0 0 10 10 8 8 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36336.1 - 1.3e-41 137.6 24.2 1e-06 28.4 0.1 11.0 10 1 1 11 11 11 8 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36336.1 - 1.1e-39 131.3 56.1 1.7e-06 27.7 0.6 10.8 10 0 0 10 10 10 9 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36336.1 - 3.6e-38 126.6 41.9 5e-06 26.2 0.8 10.4 10 0 0 10 10 10 8 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36336.1 - 4e-17 62.6 0.0 0.097 13.3 0.0 7.2 6 1 1 7 7 7 3 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO36336.1 - 2.4e-13 50.6 0.3 2.4e-13 50.6 0.3 1.8 2 0 0 2 2 1 1 Caspase domain TPR_14 PF13428.6 ETO36336.1 - 4.2e-12 45.8 0.0 6.1 7.9 0.0 8.2 9 0 0 9 9 9 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36336.1 - 1.6e-09 37.8 17.5 0.59 10.9 0.1 9.1 9 0 0 9 9 9 2 Tetratricopeptide repeat TPR_MalT PF17874.1 ETO36336.1 - 1.7e-08 34.2 0.0 0.025 14.0 0.0 3.3 1 1 1 3 3 3 3 MalT-like TPR region TPR_11 PF13414.6 ETO36336.1 - 2.8e-07 30.1 46.4 0.0035 17.0 1.0 10.0 8 1 2 10 10 9 3 TPR repeat DUF5113 PF17140.4 ETO36336.1 - 2.6e-05 24.1 36.4 0.12 12.2 2.2 8.2 9 0 0 9 9 9 3 Domain of unknown function (DUF5113) TPR_19 PF14559.6 ETO36336.1 - 0.0012 19.3 2.6 14 6.3 0.1 5.5 4 1 3 7 7 7 0 Tetratricopeptide repeat OEP PF02321.18 ETO36336.1 - 0.0014 18.4 6.6 0.53 10.1 0.4 3.4 2 1 1 3 3 3 2 Outer membrane efflux protein RE_MamI PF09567.10 ETO36336.1 - 0.0034 17.0 1.5 0.13 11.9 0.9 3.1 2 0 0 2 2 2 1 MamI restriction endonuclease MIT PF04212.18 ETO36336.1 - 0.0052 16.8 32.2 6.6 6.9 0.2 8.0 7 0 0 7 7 7 2 MIT (microtubule interacting and transport) domain DUF3856 PF12968.7 ETO36336.1 - 0.0091 16.1 12.9 7.4 6.6 0.1 6.1 3 1 2 6 6 6 1 Domain of Unknown Function (DUF3856) Phage_Treg PF04761.12 ETO36336.1 - 0.02 15.0 4.2 0.36 11.0 0.1 4.1 3 0 0 3 3 3 0 Lactococcus bacteriophage putative transcription regulator Sel1 PF08238.12 ETO36336.1 - 0.058 14.1 23.3 1 10.2 0.1 6.9 7 0 0 7 7 6 0 Sel1 repeat TPR_17 PF13431.6 ETO36336.1 - 0.077 13.4 28.4 1.7 9.2 0.0 9.2 12 0 0 12 12 9 0 Tetratricopeptide repeat TPR_3 PF07720.12 ETO36336.1 - 0.53 10.3 33.8 0.21 11.6 0.7 6.3 7 0 0 7 7 5 0 Tetratricopeptide repeat PPR PF01535.20 ETO36336.1 - 1.8 9.0 21.2 3.7 8.0 0.0 7.9 8 0 0 8 8 8 0 PPR repeat GCD14 PF08704.10 ETO36337.1 - 0.22 11.2 4.0 0.17 11.5 0.2 2.3 2 0 0 2 2 2 0 tRNA methyltransferase complex GCD14 subunit Orf78 PF06024.12 ETO36337.1 - 8.1 6.8 15.7 3.7 7.9 0.5 4.0 2 2 1 3 3 3 0 Orf78 (ac78) WD40 PF00400.32 ETO36338.1 - 7e-28 96.3 21.6 1.7e-06 28.6 0.7 6.7 6 0 0 6 6 6 5 WD domain, G-beta repeat Nup160 PF11715.8 ETO36338.1 - 6.3e-12 44.9 2.1 0.0061 15.3 0.0 4.1 1 1 3 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36338.1 - 3.5e-10 40.0 3.0 0.21 11.9 0.0 5.3 4 1 1 6 6 5 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36338.1 - 0.00034 20.0 1.9 2.9 7.1 0.1 3.9 1 1 2 3 3 3 2 WD40-like domain HARP PF07443.13 ETO36338.1 - 0.0026 17.4 0.2 0.54 9.9 0.0 3.7 4 0 0 4 4 4 1 HepA-related protein (HARP) DUF3150 PF11348.8 ETO36338.1 - 0.078 12.2 1.9 0.12 11.6 1.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3150) Zwint PF15556.6 ETO36338.1 - 0.1 12.0 5.9 0.18 11.3 5.9 1.4 1 0 0 1 1 1 0 ZW10 interactor DUF5570 PF17731.1 ETO36338.1 - 0.29 11.2 2.0 28 4.8 0.2 3.1 2 2 1 3 3 3 0 Family of unknown function (DUF5570) OmpH PF03938.14 ETO36338.1 - 0.41 11.0 12.0 0.64 10.4 12.0 1.2 1 0 0 1 1 1 0 Outer membrane protein (OmpH-like) AAA_32 PF13654.6 ETO36338.1 - 0.57 8.9 10.8 0.7 8.6 10.8 1.1 1 0 0 1 1 1 0 AAA domain TMPIT PF07851.13 ETO36338.1 - 1.9 7.7 9.7 3.2 6.9 9.7 1.3 1 0 0 1 1 1 0 TMPIT-like protein DUF1664 PF07889.12 ETO36338.1 - 6.5 6.8 6.5 2.9 8.0 2.2 2.1 1 1 1 2 2 2 0 Protein of unknown function (DUF1664) AAA PF00004.29 ETO36339.1 - 2.9e-10 40.7 0.0 0.00042 20.7 0.0 2.9 2 0 0 2 2 2 2 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO36339.1 - 7.6e-10 38.6 0.0 2.1e-05 24.1 0.0 2.6 2 0 0 2 2 2 2 P-loop containing dynein motor region AAA_5 PF07728.14 ETO36339.1 - 8.9e-09 35.5 0.2 5.7e-05 23.1 0.0 3.7 3 1 0 3 3 3 2 AAA domain (dynein-related subfamily) AAA_22 PF13401.6 ETO36339.1 - 1.5e-07 31.8 0.0 0.023 15.0 0.0 3.3 2 1 0 2 2 2 2 AAA domain RsgA_GTPase PF03193.16 ETO36339.1 - 1.9e-05 24.6 0.1 0.00023 21.1 0.0 2.5 2 0 0 2 2 2 1 RsgA GTPase AAA_16 PF13191.6 ETO36339.1 - 2.2e-05 24.9 0.0 0.0033 17.8 0.0 3.2 3 1 1 4 4 3 1 AAA ATPase domain ABC_tran PF00005.27 ETO36339.1 - 6e-05 23.6 0.0 0.0011 19.5 0.0 2.6 2 0 0 2 2 2 1 ABC transporter Viral_helicase1 PF01443.18 ETO36339.1 - 7.2e-05 22.6 0.4 0.0045 16.8 0.0 2.7 3 0 0 3 3 3 1 Viral (Superfamily 1) RNA helicase AAA_14 PF13173.6 ETO36339.1 - 0.00043 20.3 0.0 0.03 14.4 0.0 3.1 2 0 0 2 2 2 1 AAA domain ATPase_2 PF01637.18 ETO36339.1 - 0.00055 19.9 2.3 0.29 11.0 0.0 3.9 3 1 0 3 3 3 1 ATPase domain predominantly from Archaea MCM PF00493.23 ETO36339.1 - 0.00063 18.9 0.2 0.2 10.7 0.0 2.9 2 0 0 2 2 2 1 MCM P-loop domain AAA_8 PF12780.7 ETO36339.1 - 0.00075 18.9 0.6 0.0036 16.7 0.0 2.4 3 0 0 3 3 3 1 P-loop containing dynein motor region D4 PduV-EutP PF10662.9 ETO36339.1 - 0.0021 17.8 0.0 0.045 13.5 0.1 2.7 3 0 0 3 3 3 1 Ethanolamine utilisation - propanediol utilisation AAA_2 PF07724.14 ETO36339.1 - 0.0025 18.0 0.0 0.051 13.7 0.0 2.7 2 0 0 2 2 2 1 AAA domain (Cdc48 subfamily) DUF815 PF05673.13 ETO36339.1 - 0.0056 15.9 0.0 0.033 13.4 0.0 2.2 2 0 0 2 2 2 1 Protein of unknown function (DUF815) IstB_IS21 PF01695.17 ETO36339.1 - 0.0065 16.2 0.0 0.95 9.2 0.0 3.3 3 1 0 3 3 3 1 IstB-like ATP binding protein Rad17 PF03215.15 ETO36339.1 - 0.011 15.7 0.4 0.1 12.5 0.0 2.8 3 0 0 3 3 3 0 Rad17 P-loop domain TsaE PF02367.17 ETO36339.1 - 0.024 14.6 0.2 0.13 12.3 0.0 2.3 3 0 0 3 3 2 0 Threonylcarbamoyl adenosine biosynthesis protein TsaE Mg_chelatase PF01078.21 ETO36339.1 - 0.028 13.8 0.7 5.2 6.4 0.0 3.5 3 1 0 3 3 3 0 Magnesium chelatase, subunit ChlI AAA_18 PF13238.6 ETO36339.1 - 0.053 14.1 0.1 1.7 9.2 0.0 3.1 3 0 0 3 3 2 0 AAA domain Sigma54_activat PF00158.26 ETO36339.1 - 0.057 13.1 0.0 1.9 8.2 0.0 2.9 3 0 0 3 3 2 0 Sigma-54 interaction domain NACHT PF05729.12 ETO36339.1 - 0.058 13.3 1.1 0.69 9.8 0.1 3.1 3 1 0 3 3 3 0 NACHT domain AAA_30 PF13604.6 ETO36339.1 - 0.074 12.8 0.0 7.7 6.2 0.0 2.5 2 1 0 2 2 2 0 AAA domain AAA_24 PF13479.6 ETO36339.1 - 0.092 12.5 0.0 0.36 10.5 0.0 2.1 2 0 0 2 2 1 0 AAA domain RNA_helicase PF00910.22 ETO36339.1 - 0.12 12.8 0.0 2.6 8.5 0.0 2.8 2 0 0 2 2 2 0 RNA helicase AAA_19 PF13245.6 ETO36339.1 - 0.45 10.9 3.7 4.2 7.7 0.1 3.4 2 2 1 3 3 3 0 AAA domain zf-TRAF PF02176.18 ETO36341.1 - 1.8e-07 31.7 4.1 5.4e-07 30.2 3.0 2.4 1 1 1 2 2 2 1 TRAF-type zinc finger FAM195 PF14799.6 ETO36342.1 - 0.12 12.7 0.0 0.15 12.4 0.0 1.2 1 0 0 1 1 1 0 FAM195 family CelTOS PF18659.1 ETO36342.1 - 0.12 12.8 0.0 0.17 12.3 0.0 1.3 1 0 0 1 1 1 0 Cell-traversal protein for ookinetes and sporozoites NAF PF03822.14 ETO36344.1 - 0.3 11.3 3.5 6.8 7.0 0.4 3.1 3 0 0 3 3 3 0 NAF domain PT PF04886.12 ETO36347.1 - 4.1e-19 67.8 144.2 8.8 6.0 33.2 7.7 1 1 1 2 2 2 1 PT repeat TSP_1 PF00090.19 ETO36347.1 - 5.3e-06 26.6 10.6 1.6e-05 25.1 10.6 1.9 1 0 0 1 1 1 1 Thrombospondin type 1 domain PPL5 PF18168.1 ETO36348.1 - 1.2 8.4 4.6 1.4 8.2 4.6 1.1 1 0 0 1 1 1 0 Prim-pol family 5 Nop14 PF04147.12 ETO36348.1 - 3.9 5.6 14.0 4 5.5 14.0 1.0 1 0 0 1 1 1 0 Nop14-like family Popeye PF04831.13 ETO36349.1 - 5.7e-22 78.4 5.1 8.8e-22 77.8 5.1 1.4 1 0 0 1 1 1 1 Popeye protein conserved region P22_AR_N PF10547.9 ETO36349.1 - 0.14 12.5 0.2 6 7.2 0.1 2.6 2 1 0 2 2 2 0 P22_AR N-terminal domain WD40 PF00400.32 ETO36350.1 - 4.4e-139 448.2 73.5 1.6e-10 41.4 0.2 14.6 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36350.1 - 1.3e-40 137.6 14.7 0.00075 19.7 0.0 13.9 1 1 13 14 14 14 14 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36350.1 - 1.9e-18 66.5 14.3 0.051 12.5 0.1 12.0 1 1 11 12 12 12 6 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36350.1 - 4e-18 65.8 8.2 0.0033 16.8 0.1 7.8 3 3 5 8 8 8 7 WD40-like domain DUF727 PF05303.12 ETO36350.1 - 7.7e-07 29.1 1.2 6.2 6.9 0.0 8.9 3 3 7 10 10 10 1 Protein of unknown function (DUF727) PD40 PF07676.12 ETO36350.1 - 1.6e-06 27.9 17.7 15 5.6 0.0 10.2 11 0 0 11 11 11 1 WD40-like Beta Propeller Repeat NACHT PF05729.12 ETO36350.1 - 2.4e-05 24.3 0.0 5.3e-05 23.2 0.0 1.5 1 0 0 1 1 1 1 NACHT domain Pentapeptide PF00805.22 ETO36350.1 - 0.0011 18.5 0.3 0.023 14.3 0.0 2.2 1 1 1 2 2 2 1 Pentapeptide repeats (8 copies) AAA_18 PF13238.6 ETO36350.1 - 0.009 16.6 0.6 0.053 14.1 0.0 2.7 2 1 1 3 3 2 1 AAA domain AAA_22 PF13401.6 ETO36350.1 - 0.02 15.1 0.0 0.082 13.2 0.0 2.1 1 1 0 1 1 1 0 AAA domain Endonuc_subdom PF09062.10 ETO36350.1 - 0.022 15.6 1.0 0.19 12.6 1.0 2.7 1 0 0 1 1 1 0 PI-PfuI Endonuclease subdomain Ras PF00071.22 ETO36351.1 - 4.8e-20 71.8 0.6 4.2e-11 42.7 0.4 2.8 2 0 0 2 2 2 2 Ras family Roc PF08477.13 ETO36351.1 - 4.1e-13 49.6 0.0 7.6e-07 29.4 0.0 2.9 2 0 0 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO36351.1 - 5.2e-06 26.0 0.7 0.00087 18.8 0.1 2.9 3 0 0 3 3 3 1 ADP-ribosylation factor family RsgA_GTPase PF03193.16 ETO36351.1 - 0.028 14.3 1.3 7.4 6.4 0.0 3.7 4 0 0 4 4 4 0 RsgA GTPase AAA_16 PF13191.6 ETO36351.1 - 0.067 13.6 0.0 0.13 12.6 0.0 1.6 1 0 0 1 1 1 0 AAA ATPase domain TniB PF05621.11 ETO36351.1 - 0.067 12.6 0.0 0.13 11.7 0.0 1.4 1 0 0 1 1 1 0 Bacterial TniB protein Peroxin-13_N PF04088.13 ETO36351.1 - 6.6 7.0 9.9 5.2 7.3 1.7 2.4 2 0 0 2 2 2 0 Peroxin 13, N-terminal region Afi1 PF07792.12 ETO36353.1 - 0.0034 17.9 0.4 0.0034 17.9 0.4 2.4 1 1 1 2 2 2 1 Docking domain of Afi1 for Arf3 in vesicle trafficking DUF2207 PF09972.9 ETO36353.1 - 0.032 13.0 3.8 0.058 12.2 3.8 1.4 1 0 0 1 1 1 0 Predicted membrane protein (DUF2207) Peptidase_S64 PF08192.11 ETO36353.1 - 1.1 7.7 12.5 1.4 7.3 12.5 1.3 1 0 0 1 1 1 0 Peptidase family S64 CAC1F_C PF16885.5 ETO36353.1 - 5.7 6.5 13.0 12 5.4 13.1 1.5 1 1 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term Bud13 PF09736.9 ETO36353.1 - 7.9 6.9 22.0 0.55 10.6 13.8 2.5 1 1 1 2 2 2 0 Pre-mRNA-splicing factor of RES complex FTA4 PF13093.6 ETO36354.1 - 0.042 13.7 0.0 0.052 13.4 0.0 1.1 1 0 0 1 1 1 0 Kinetochore complex Fta4 of Sim4 subunit, or CENP-50 DNA_gyraseA_C PF03989.13 ETO36354.1 - 0.13 11.8 0.0 0.21 11.1 0.0 1.4 1 0 0 1 1 1 0 DNA gyrase C-terminal domain, beta-propeller CorA PF01544.18 ETO36355.1 - 4.9e-29 101.6 1.3 1.3e-28 100.2 1.3 1.6 1 1 0 1 1 1 1 CorA-like Mg2+ transporter protein DUF3342 PF11822.8 ETO36355.1 - 0.054 13.7 0.0 0.12 12.5 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF3342) DUF5533 PF17685.1 ETO36355.1 - 0.11 12.8 0.3 0.21 12.0 0.3 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5533) RNA_pol_Rpb2_6 PF00562.28 ETO36356.1 - 5e-30 104.8 0.2 5.8e-30 104.6 0.2 1.0 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 6 RNA_pol_Rpb2_7 PF04560.20 ETO36356.1 - 9.3e-13 48.4 0.2 1.7e-12 47.5 0.2 1.4 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 7 tRNA_NucTransf2 PF09249.11 ETO36356.1 - 0.16 12.2 0.1 0.24 11.7 0.1 1.2 1 0 0 1 1 1 0 tRNA nucleotidyltransferase, second domain SbsC_C PF18058.1 ETO36356.1 - 0.23 11.7 0.6 0.31 11.3 0.6 1.1 1 0 0 1 1 1 0 SbsC C-terminal domain RNA_pol_Rpb2_6 PF00562.28 ETO36357.1 - 1.8e-62 211.6 0.2 1.8e-62 211.6 0.2 2.5 2 1 0 2 2 2 1 RNA polymerase Rpb2, domain 6 FAM176 PF14851.6 ETO36357.1 - 1.4e-05 24.7 5.0 2.3e-05 24.1 5.0 1.3 1 0 0 1 1 1 1 FAM176 family OAD_gamma PF04277.13 ETO36357.1 - 0.0015 19.1 0.7 0.0042 17.7 0.7 1.8 1 0 0 1 1 1 1 Oxaloacetate decarboxylase, gamma chain DUF2615 PF11027.8 ETO36357.1 - 0.0018 18.4 0.3 0.0045 17.1 0.3 1.7 1 0 0 1 1 1 1 Protein of unknown function (DUF2615) OATP PF03137.20 ETO36357.1 - 0.0078 14.6 2.2 0.01 14.2 2.2 1.2 1 0 0 1 1 1 1 Organic Anion Transporter Polypeptide (OATP) family IgaA PF07095.11 ETO36357.1 - 0.0092 14.0 1.3 0.011 13.7 1.3 1.1 1 0 0 1 1 1 1 Intracellular growth attenuator protein IgaA TMEM154 PF15102.6 ETO36357.1 - 0.011 15.7 0.9 0.022 14.7 0.9 1.6 1 0 0 1 1 1 0 TMEM154 protein family Mem_trans PF03547.18 ETO36357.1 - 0.012 14.0 1.2 0.011 14.1 1.2 1.1 1 0 0 1 1 1 0 Membrane transport protein Nucleoside_tran PF01733.18 ETO36357.1 - 0.012 15.0 1.3 0.021 14.2 1.3 1.4 1 0 0 1 1 1 0 Nucleoside transporter Connexin PF00029.19 ETO36357.1 - 0.012 15.3 8.0 0.022 14.5 8.0 1.4 1 0 0 1 1 1 0 Connexin OSTbeta PF15048.6 ETO36357.1 - 0.017 15.3 2.9 0.029 14.5 2.9 1.5 1 0 0 1 1 1 0 Organic solute transporter subunit beta protein EphA2_TM PF14575.6 ETO36357.1 - 0.04 14.8 5.6 0.12 13.3 5.6 2.0 1 1 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain V_ATPase_I PF01496.19 ETO36357.1 - 0.041 11.8 9.3 0.056 11.4 9.3 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Phage_Gp23 PF10669.9 ETO36357.1 - 0.042 14.2 11.0 0.099 13.0 10.1 2.1 2 0 0 2 2 2 0 Protein gp23 (Bacteriophage A118) Tmemb_9 PF05434.11 ETO36357.1 - 0.045 13.6 7.6 0.084 12.8 7.6 1.5 1 0 0 1 1 1 0 TMEM9 EspG PF06872.11 ETO36357.1 - 0.046 12.3 0.0 0.068 11.7 0.0 1.2 1 0 0 1 1 1 0 EspG protein Pox_Ag35 PF03286.14 ETO36357.1 - 0.052 13.3 9.8 0.087 12.6 9.8 1.2 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Endostatin PF06482.11 ETO36357.1 - 0.063 12.7 7.4 0.095 12.1 7.4 1.2 1 0 0 1 1 1 0 Collagenase NC10 and Endostatin Ctr PF04145.15 ETO36357.1 - 0.064 13.9 0.4 0.093 13.3 0.4 1.4 1 0 0 1 1 1 0 Ctr copper transporter family CBP_BcsG PF11658.8 ETO36357.1 - 0.11 10.9 2.3 0.14 10.5 2.3 1.1 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG Eapp_C PF10238.9 ETO36357.1 - 0.12 12.5 4.6 0.2 11.7 4.6 1.4 1 0 0 1 1 1 0 E2F-associated phosphoprotein SID-1_RNA_chan PF13965.6 ETO36357.1 - 0.15 10.5 3.9 0.2 10.0 3.9 1.2 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Herpes_gE PF02480.16 ETO36357.1 - 0.17 10.6 1.0 0.25 10.0 1.0 1.2 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein E DNApol_Exo PF18136.1 ETO36357.1 - 0.21 10.7 5.9 0.34 10.0 5.9 1.3 1 0 0 1 1 1 0 DNA mitochondrial polymerase exonuclease domain FHIPEP PF00771.20 ETO36357.1 - 0.21 10.0 2.5 0.26 9.7 2.5 1.1 1 0 0 1 1 1 0 FHIPEP family O-antigen_lig PF13425.6 ETO36357.1 - 0.24 10.1 5.4 0.4 9.4 5.4 1.5 1 0 0 1 1 1 0 O-antigen ligase like membrane protein MAP17 PF15807.5 ETO36357.1 - 0.3 11.3 9.0 0.62 10.3 9.0 1.5 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 TMEM51 PF15345.6 ETO36357.1 - 0.3 10.9 11.2 0.51 10.1 11.2 1.4 1 1 0 1 1 1 0 Transmembrane protein 51 Sporozoite_P67 PF05642.11 ETO36357.1 - 0.3 9.1 1.4 0.44 8.6 1.4 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen Presenilin PF01080.17 ETO36357.1 - 0.32 9.7 6.3 0.52 9.0 6.3 1.4 1 0 0 1 1 1 0 Presenilin DDRGK PF09756.9 ETO36357.1 - 0.38 10.3 19.4 0.64 9.6 19.4 1.3 1 0 0 1 1 1 0 DDRGK domain NEMP PF10225.9 ETO36357.1 - 0.43 10.2 2.4 0.77 9.4 2.4 1.5 1 0 0 1 1 1 0 NEMP family DNA_pol_delta_4 PF04081.13 ETO36357.1 - 0.6 10.5 10.9 1.1 9.6 10.9 1.3 1 0 0 1 1 1 0 DNA polymerase delta, subunit 4 Sin_N PF04801.13 ETO36357.1 - 0.76 8.9 13.6 1.1 8.3 13.6 1.2 1 0 0 1 1 1 0 Sin-like protein conserved region CSG2 PF16965.5 ETO36357.1 - 0.97 8.3 3.9 1.7 7.5 3.9 1.4 1 0 0 1 1 1 0 Ceramide synthase regulator MscS_TM PF12794.7 ETO36357.1 - 1 8.1 6.5 1.4 7.7 6.5 1.2 1 0 0 1 1 1 0 Mechanosensitive ion channel inner membrane domain 1 Serinc PF03348.15 ETO36357.1 - 1.1 8.1 3.7 0.45 9.4 1.2 1.7 2 0 0 2 2 2 0 Serine incorporator (Serinc) RR_TM4-6 PF06459.12 ETO36357.1 - 1.1 9.0 12.6 1.7 8.4 12.6 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Conotoxin PF02950.17 ETO36357.1 - 1.2 10.2 4.5 4 8.5 4.5 2.0 1 1 0 1 1 1 0 Conotoxin Peptidase_S49_N PF08496.10 ETO36357.1 - 1.4 8.9 10.7 2.7 8.0 10.7 1.5 1 0 0 1 1 1 0 Peptidase family S49 N-terminal 7TM_GPCR_Sru PF10322.9 ETO36357.1 - 1.7 7.9 5.2 2.7 7.2 4.6 1.6 2 0 0 2 2 1 0 Serpentine type 7TM GPCR chemoreceptor Sru RPN2_C PF18004.1 ETO36357.1 - 2.7 7.9 15.3 5.1 7.0 15.3 1.4 1 0 0 1 1 1 0 26S proteasome regulatory subunit RPN2 C-terminal domain S-antigen PF05756.11 ETO36357.1 - 2.9 8.3 7.4 6.4 7.2 7.4 1.6 1 0 0 1 1 1 0 S-antigen protein Neur_chan_memb PF02932.16 ETO36357.1 - 3.4 7.7 6.6 4.9 7.1 6.6 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CDC45 PF02724.14 ETO36357.1 - 3.5 5.8 10.9 4.7 5.4 10.9 1.2 1 0 0 1 1 1 0 CDC45-like protein DUF4834 PF16118.5 ETO36357.1 - 3.6 8.6 12.7 0.32 12.0 8.0 1.7 2 0 0 2 2 1 0 Domain of unknown function (DUF4834) DUF4446 PF14584.6 ETO36357.1 - 4.2 7.3 11.2 1.8 8.5 8.5 1.8 2 0 0 2 2 1 0 Protein of unknown function (DUF4446) CLN3 PF02487.17 ETO36357.1 - 4.4 6.2 8.4 5.6 5.9 8.3 1.3 1 1 0 1 1 1 0 CLN3 protein Vpu PF00558.19 ETO36357.1 - 6.2 6.7 6.6 16 5.4 6.6 1.8 1 1 0 1 1 1 0 Vpu protein RNA_pol_Rpa2_4 PF06883.12 ETO36358.1 - 0.00048 20.1 0.0 0.0014 18.6 0.0 1.8 1 1 0 1 1 1 1 RNA polymerase I, Rpa2 specific domain RNA_pol_Rpb2_3 PF04565.16 ETO36358.1 - 0.0043 17.2 0.0 0.0093 16.1 0.0 1.6 1 0 0 1 1 1 1 RNA polymerase Rpb2, domain 3 WD40 PF00400.32 ETO36359.1 - 4.8e-34 115.8 1.8 7.1e-09 36.2 0.0 4.1 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36359.1 - 1.3e-13 51.0 0.5 0.0017 18.6 0.0 4.0 1 1 3 4 4 4 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36359.1 - 2.5e-12 46.4 0.0 0.0018 17.3 0.0 4.0 1 1 3 4 4 4 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO36359.1 - 1.2e-07 31.8 0.2 0.0015 18.4 0.0 2.2 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO36359.1 - 1.6e-06 27.7 0.5 0.00036 20.0 0.1 1.8 1 1 1 2 2 2 2 WD40-like domain PD40 PF07676.12 ETO36359.1 - 1.2e-05 25.1 3.3 1.6 8.8 0.0 4.6 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO36359.1 - 0.00036 19.4 2.1 1.2 7.8 0.3 3.0 1 1 2 3 3 3 3 Nup133 N terminal like Proteasome_A_N PF10584.9 ETO36359.1 - 0.00053 19.6 2.4 0.1 12.3 0.0 4.0 4 0 0 4 4 4 1 Proteasome subunit A N-terminal signature DUF5122 PF17164.4 ETO36359.1 - 0.0036 17.6 0.1 0.58 10.5 0.2 2.6 2 0 0 2 2 2 1 Domain of unknown function (DUF5122) beta-propeller PQQ_2 PF13360.6 ETO36359.1 - 0.0084 15.7 0.0 0.013 15.1 0.0 1.4 1 0 0 1 1 1 1 PQQ-like domain Str_synth PF03088.16 ETO36359.1 - 0.017 15.2 0.0 3.6 7.8 0.0 2.6 2 1 1 3 3 3 0 Strictosidine synthase PALB2_WD40 PF16756.5 ETO36359.1 - 0.031 13.2 0.1 2.6 6.9 0.0 2.4 1 1 1 2 2 2 0 Partner and localizer of BRCA2 WD40 domain DUF5046 PF16465.5 ETO36359.1 - 0.04 13.4 0.0 0.052 13.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF5046) Nup160 PF11715.8 ETO36359.1 - 0.061 12.0 0.5 0.83 8.2 0.0 2.3 1 1 1 2 2 2 0 Nucleoporin Nup120/160 MaoC_dehydratas PF01575.19 ETO36360.1 - 2.7e-13 49.6 0.0 4.8e-13 48.8 0.0 1.6 1 1 0 1 1 1 1 MaoC like domain CBFD_NFYB_HMF PF00808.23 ETO36361.1 - 1.5e-10 41.2 6.8 9.8e-08 32.2 0.1 2.7 3 0 0 3 3 3 2 Histone-like transcription factor (CBF/NF-Y) and archaeal histone CSG2 PF16965.5 ETO36361.1 - 0.36 9.7 5.9 0.4 9.6 5.9 1.2 1 0 0 1 1 1 0 Ceramide synthase regulator Neur_chan_memb PF02932.16 ETO36361.1 - 1.9 8.5 6.4 2.6 8.1 6.4 1.3 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region CobT PF06213.12 ETO36361.1 - 2.1 7.7 20.2 3 7.2 20.2 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT YrhC PF14143.6 ETO36362.1 - 0.22 11.6 1.3 2.2 8.4 0.2 2.3 2 0 0 2 2 2 0 YrhC-like protein Phasin_2 PF09361.10 ETO36362.1 - 0.28 11.5 13.3 1.5 9.1 1.5 3.5 3 0 0 3 3 3 0 Phasin protein HisKA_3 PF07730.13 ETO36362.1 - 0.34 11.5 6.4 0.15 12.6 0.5 3.2 3 0 0 3 3 3 0 Histidine kinase SARAF PF06682.12 ETO36362.1 - 2.8 7.5 8.6 0.3 10.7 0.9 2.5 2 1 1 3 3 3 0 SOCE-associated regulatory factor of calcium homoeostasis START PF01852.19 ETO36365.1 - 1.9e-12 47.0 0.0 3e-12 46.4 0.0 1.2 1 0 0 1 1 1 1 START domain CENP-U PF13097.6 ETO36365.1 - 0.47 10.4 8.7 0.67 9.9 8.7 1.2 1 0 0 1 1 1 0 CENP-A nucleosome associated complex (NAC) subunit WD40 PF00400.32 ETO36366.1 - 7.4e-34 115.2 23.7 7.7e-06 26.6 1.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36366.1 - 9.7e-08 32.2 1.0 1.4 9.2 0.0 5.5 3 2 3 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36366.1 - 2e-07 30.1 12.9 0.008 14.9 1.0 5.8 4 2 2 6 6 6 4 Nucleoporin Nup120/160 HAP1_N PF04849.13 ETO36366.1 - 0.038 13.2 12.6 0.057 12.6 12.6 1.2 1 0 0 1 1 1 0 HAP1 N-terminal conserved region LydB PF16084.5 ETO36366.1 - 0.1 12.4 0.1 0.35 10.7 0.1 1.9 2 0 0 2 2 2 0 LydA-holin antagonist YabA PF06156.13 ETO36366.1 - 9.2 7.0 14.0 0.21 12.2 4.7 2.6 2 1 1 3 3 3 0 Initiation control protein YabA PUB PF09409.10 ETO36367.1 - 0.013 15.4 1.0 0.053 13.4 1.0 2.0 1 1 0 1 1 1 0 PUB domain WD40 PF00400.32 ETO36370.1 - 1.6e-19 69.9 6.5 9.3e-05 23.1 0.7 4.9 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36370.1 - 0.00039 20.7 0.2 1.9 8.8 0.0 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36370.1 - 0.0015 17.3 0.4 1.5 7.3 0.1 2.8 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40 PF00400.32 ETO36371.1 - 8.3e-15 54.9 13.5 1.7e-06 28.7 0.4 4.3 4 2 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO36371.1 - 8.2e-05 21.4 1.9 1 7.9 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36371.1 - 0.00023 21.4 0.2 2.7 8.4 0.1 3.1 3 0 0 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36371.1 - 0.0024 17.2 1.2 0.62 9.3 0.2 2.9 1 1 2 3 3 3 1 WD40-like domain BBS2_Mid PF14783.6 ETO36371.1 - 0.0061 16.6 0.9 0.02 14.9 0.2 2.0 1 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region eIF2A PF08662.11 ETO36371.1 - 0.011 15.7 3.5 0.6 9.9 1.6 2.9 1 1 3 4 4 4 0 Eukaryotic translation initiation factor eIF2A PUB PF09409.10 ETO36372.1 - 0.0043 17.0 0.8 0.015 15.2 0.3 2.1 2 0 0 2 2 2 1 PUB domain RPAP3_C PF13877.6 ETO36372.1 - 0.029 14.9 1.9 0.053 14.1 0.2 2.2 2 1 1 3 3 3 0 Potential Monad-binding region of RPAP3 DUF4296 PF14129.6 ETO36372.1 - 0.048 14.3 1.6 0.82 10.3 0.1 2.9 3 0 0 3 3 3 0 Domain of unknown function (DUF4296) CUE PF02845.16 ETO36372.1 - 0.065 13.0 0.5 0.13 12.0 0.1 1.8 2 0 0 2 2 2 0 CUE domain Rsa3 PF14615.6 ETO36372.1 - 0.13 11.9 0.5 4.8 6.8 0.0 2.6 3 0 0 3 3 3 0 Ribosome-assembly protein 3 PCI PF01399.27 ETO36372.1 - 0.19 12.3 3.4 0.22 12.0 0.7 2.2 1 1 1 2 2 2 0 PCI domain CpxA_peri PF16527.5 ETO36373.1 - 0.074 13.4 2.3 0.062 13.7 1.2 1.5 1 1 0 1 1 1 0 Two-component sensor protein CpxA, periplasmic domain WD40 PF00400.32 ETO36374.1 - 0.0081 17.0 0.6 0.018 15.9 0.4 1.7 2 0 0 2 2 2 1 WD domain, G-beta repeat Ribonuc_red_sm PF00268.21 ETO36375.1 - 0.0017 17.9 2.5 0.002 17.7 2.5 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, small chain DUF3997 PF13162.6 ETO36375.1 - 0.051 13.9 2.1 0.062 13.6 1.4 1.6 1 1 0 1 1 1 0 Protein of unknown function (DUF3997) SPARC_Ca_bdg PF10591.9 ETO36375.1 - 0.061 13.7 1.2 0.071 13.4 1.2 1.2 1 0 0 1 1 1 0 Secreted protein acidic and rich in cysteine Ca binding region EF-hand_8 PF13833.6 ETO36376.1 - 0.16 11.8 0.3 0.27 11.1 0.3 1.3 1 0 0 1 1 1 0 EF-hand domain pair WD40 PF00400.32 ETO36377.1 - 4.1e-31 106.5 5.7 2.8e-11 43.8 0.0 4.4 4 0 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36377.1 - 2.9e-12 46.7 0.2 0.0018 18.5 0.0 3.4 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36377.1 - 1.8e-06 26.9 0.8 0.046 12.4 0.0 3.1 1 1 1 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36377.1 - 3.9e-06 26.4 3.1 0.003 16.9 2.7 2.4 1 1 1 2 2 2 2 WD40-like domain Ge1_WD40 PF16529.5 ETO36377.1 - 7.7e-06 25.1 0.4 0.039 12.9 0.0 3.3 1 1 2 3 3 3 2 WD40 region of Ge1, enhancer of mRNA-decapping protein PALB2_WD40 PF16756.5 ETO36377.1 - 3.3e-05 23.0 0.4 0.0072 15.3 0.2 2.7 1 1 2 3 3 3 1 Partner and localizer of BRCA2 WD40 domain DUF5570 PF17731.1 ETO36377.1 - 0.0014 18.7 0.2 1.4 9.0 0.0 3.1 1 1 2 3 3 3 1 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO36377.1 - 0.0018 16.8 0.3 0.023 13.2 0.0 1.9 1 1 1 2 2 2 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO36377.1 - 0.0054 16.6 1.1 6.9 6.7 0.1 3.3 3 0 0 3 3 3 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO36377.1 - 0.012 14.4 0.8 0.2 10.3 0.1 2.5 1 1 2 3 3 3 0 Nup133 N terminal like ROS_MUCR PF05443.11 ETO36377.1 - 0.05 13.6 0.3 5.9 7.0 0.0 2.9 2 1 1 3 3 3 0 ROS/MUCR transcriptional regulator protein Sod_Fe_C PF02777.18 ETO36379.1 - 3.5e-08 33.6 0.1 0.0016 18.5 0.0 2.4 2 0 0 2 2 2 2 Iron/manganese superoxide dismutases, C-terminal domain Sod_Fe_N PF00081.22 ETO36379.1 - 0.065 13.7 0.0 0.15 12.6 0.0 1.6 1 0 0 1 1 1 0 Iron/manganese superoxide dismutases, alpha-hairpin domain Amino_oxidase PF01593.24 ETO36380.1 - 3.2e-16 59.7 0.0 3.4e-10 39.8 0.0 3.3 2 2 0 2 2 2 2 Flavin containing amine oxidoreductase Ank_2 PF12796.7 ETO36380.1 - 6.8e-08 33.0 0.4 1.2e-06 29.0 0.1 2.9 3 0 0 3 3 3 1 Ankyrin repeats (3 copies) NAD_binding_8 PF13450.6 ETO36380.1 - 0.00028 21.1 0.8 0.019 15.2 0.8 2.7 1 1 0 1 1 1 1 NAD(P)-binding Rossmann-like domain Thi4 PF01946.17 ETO36380.1 - 0.00092 18.5 0.1 0.0023 17.2 0.1 1.6 2 0 0 2 2 2 1 Thi4 family Pyr_redox_2 PF07992.14 ETO36380.1 - 0.0012 18.1 0.0 0.0022 17.3 0.0 1.4 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase FAD_binding_2 PF00890.24 ETO36380.1 - 0.0022 17.1 1.2 0.0055 15.8 1.1 1.4 1 1 0 1 1 1 1 FAD binding domain HI0933_like PF03486.14 ETO36380.1 - 0.0074 15.0 0.2 0.013 14.3 0.2 1.3 1 0 0 1 1 1 1 HI0933-like protein Ank_4 PF13637.6 ETO36380.1 - 0.01 16.4 0.1 2.1 9.1 0.0 2.9 2 0 0 2 2 2 0 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO36380.1 - 0.015 15.8 0.5 0.67 10.7 0.1 3.3 2 0 0 2 2 2 0 Ankyrin repeat FAD_binding_3 PF01494.19 ETO36380.1 - 0.02 14.2 0.1 0.036 13.3 0.1 1.4 1 0 0 1 1 1 0 FAD binding domain GIDA PF01134.22 ETO36380.1 - 0.025 13.7 1.5 0.039 13.0 0.2 1.9 2 0 0 2 2 2 0 Glucose inhibited division protein A Lycopene_cycl PF05834.12 ETO36380.1 - 0.041 12.9 0.2 0.07 12.2 0.2 1.3 1 0 0 1 1 1 0 Lycopene cyclase protein DAO PF01266.24 ETO36380.1 - 0.042 13.4 0.2 0.068 12.7 0.2 1.3 1 0 0 1 1 1 0 FAD dependent oxidoreductase Malic_M PF03949.15 ETO36380.1 - 0.14 11.4 0.1 0.25 10.6 0.1 1.4 1 0 0 1 1 1 0 Malic enzyme, NAD binding domain Pyr_redox_3 PF13738.6 ETO36380.1 - 2.9 7.1 6.1 0.27 10.4 1.0 1.9 2 0 0 2 2 2 0 Pyridine nucleotide-disulphide oxidoreductase Baculo_LEF-11 PF06385.12 ETO36383.1 - 0.0011 19.4 0.1 0.0045 17.5 0.1 2.0 1 1 0 1 1 1 1 Baculovirus LEF-11 protein Urb2 PF10441.9 ETO36383.1 - 0.031 14.2 0.3 0.036 14.0 0.3 1.1 1 0 0 1 1 1 0 Urb2/Npa2 family DSHCT PF08148.12 ETO36383.1 - 0.082 12.6 0.1 0.1 12.3 0.1 1.2 1 0 0 1 1 1 0 DSHCT (NUC185) domain DUF2555 PF10742.9 ETO36383.1 - 0.15 11.9 0.3 0.36 10.7 0.1 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF2555) Ank_2 PF12796.7 ETO36385.1 - 0.00011 22.7 0.5 0.00066 20.2 0.1 2.3 2 0 0 2 2 2 1 Ankyrin repeats (3 copies) Ank_3 PF13606.6 ETO36385.1 - 0.00021 21.4 1.9 0.048 14.2 0.0 3.8 4 0 0 4 4 4 1 Ankyrin repeat Ank_4 PF13637.6 ETO36385.1 - 0.0022 18.6 1.7 0.016 15.8 0.5 2.6 2 0 0 2 2 2 1 Ankyrin repeats (many copies) Ank_5 PF13857.6 ETO36385.1 - 0.019 15.3 0.0 0.061 13.7 0.0 1.9 1 0 0 1 1 1 0 Ankyrin repeats (many copies) SPRY PF00622.28 ETO36386.1 - 1.6e-12 47.6 0.1 3.6e-12 46.4 0.1 1.6 1 0 0 1 1 1 1 SPRY domain SOG2 PF10428.9 ETO36386.1 - 0.13 11.4 12.2 0.16 11.2 12.2 1.1 1 0 0 1 1 1 0 RAM signalling pathway protein DUF572 PF04502.13 ETO36386.1 - 1.1 8.8 14.8 1.6 8.3 14.8 1.1 1 0 0 1 1 1 0 Family of unknown function (DUF572) BSP_II PF05432.11 ETO36386.1 - 1.9 8.1 11.9 3.8 7.1 11.9 1.5 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) NOA36 PF06524.12 ETO36388.1 - 0.016 14.6 3.6 0.014 14.7 3.6 1.1 1 0 0 1 1 1 0 NOA36 protein DNA_pol_phi PF04931.13 ETO36388.1 - 0.029 12.5 8.2 0.029 12.5 8.2 1.1 1 0 0 1 1 1 0 DNA polymerase phi tRNA_NucTransf2 PF09249.11 ETO36388.1 - 0.035 14.3 0.4 0.054 13.8 0.2 1.4 1 1 0 1 1 1 0 tRNA nucleotidyltransferase, second domain ORC_WH_C PF18137.1 ETO36388.1 - 0.08 13.0 5.5 0.11 12.6 5.5 1.2 1 0 0 1 1 1 0 Origin recognition complex winged helix C-terminal DUF2457 PF10446.9 ETO36388.1 - 0.44 9.7 11.1 0.5 9.4 11.1 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) PPP4R2 PF09184.11 ETO36388.1 - 0.53 9.8 14.3 0.91 9.1 14.3 1.4 1 0 0 1 1 1 0 PPP4R2 WD40 PF00400.32 ETO36389.1 - 0.0002 22.1 5.3 0.0087 16.9 0.0 4.0 3 1 0 3 3 3 1 WD domain, G-beta repeat SR-25 PF10500.9 ETO36389.1 - 0.2 11.2 7.2 0.33 10.5 7.2 1.3 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Herpes_pp85 PF04637.12 ETO36389.1 - 2.2 6.6 3.8 3 6.1 3.8 1.1 1 0 0 1 1 1 0 Herpesvirus phosphoprotein 85 (HHV6-7 U14/HCMV UL25) Mito_fiss_reg PF05308.11 ETO36391.1 - 0.0048 17.0 7.9 0.0098 16.0 7.9 1.5 1 0 0 1 1 1 1 Mitochondrial fission regulator DNA_topoisoIV PF00521.20 ETO36391.1 - 0.0059 15.6 1.6 0.0059 15.6 1.6 1.7 2 0 0 2 2 2 1 DNA gyrase/topoisomerase IV, subunit A TraG-D_C PF12696.7 ETO36391.1 - 0.052 13.5 4.4 0.1 12.6 0.1 2.8 2 0 0 2 2 2 0 TraM recognition site of TraD and TraG baeRF_family3 PF18845.1 ETO36391.1 - 1.7 8.9 6.7 0.29 11.4 1.0 2.5 2 1 0 2 2 2 0 Bacterial archaeo-eukaryotic release factor family 3 CAP_N PF01213.19 ETO36391.1 - 5.3 6.4 14.9 13 5.2 14.7 1.9 1 1 0 1 1 1 0 Adenylate cyclase associated (CAP) N terminal MIEAP PF16026.5 ETO36391.1 - 6 7.0 17.1 1.1 9.4 4.9 3.9 3 2 0 3 3 3 0 Mitochondria-eating protein WD40 PF00400.32 ETO36397.1 - 8.5e-11 42.2 5.4 0.00073 20.3 0.6 4.0 3 2 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO36397.1 - 0.00036 19.3 0.0 0.36 9.4 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36397.1 - 0.00047 20.4 0.1 0.22 11.8 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Nucleoporin_N PF08801.11 ETO36397.1 - 0.004 16.0 0.6 0.13 11.0 0.1 2.0 1 1 1 2 2 2 2 Nup133 N terminal like RhgB_N PF09284.10 ETO36397.1 - 0.026 14.1 0.0 0.031 13.8 0.0 1.1 1 0 0 1 1 1 0 Rhamnogalacturonan lyase B, N-terminal Vpu PF00558.19 ETO36398.1 - 0.031 14.0 2.0 5.8 6.8 0.1 2.9 3 0 0 3 3 3 0 Vpu protein DUF3139 PF11337.8 ETO36398.1 - 0.064 13.9 0.6 5.5 7.7 0.0 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF3139) SieB PF14163.6 ETO36398.1 - 2.3 7.7 6.8 0.84 9.1 2.0 2.2 1 1 0 2 2 2 0 Super-infection exclusion protein B LRR_8 PF13855.6 ETO36400.1 - 3.1e-13 49.3 40.5 4.2e-06 26.4 6.9 3.6 1 1 3 5 5 5 5 Leucine rich repeat LRR_4 PF12799.7 ETO36400.1 - 8.9e-08 32.3 23.0 0.0038 17.6 3.9 4.2 2 2 2 5 5 5 4 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO36400.1 - 2.9e-06 27.1 17.1 2 9.3 0.2 6.2 6 0 0 6 6 6 4 Leucine Rich Repeat DUF1299 PF06975.11 ETO36400.1 - 5.6 7.1 7.0 5.2 7.2 0.0 2.9 3 1 0 3 3 3 0 Protein of unknown function (DUF1299) Pkinase PF00069.25 ETO36401.1 - 1.8e-32 112.8 0.0 2.2e-32 112.5 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36401.1 - 4.6e-08 32.7 0.3 0.0079 15.5 0.0 2.2 2 0 0 2 2 2 2 Protein tyrosine kinase Fis1_TPR_C PF14853.6 ETO36401.1 - 0.064 13.3 0.0 0.13 12.4 0.0 1.5 1 0 0 1 1 1 0 Fis1 C-terminal tetratricopeptide repeat DUF1612 PF07756.12 ETO36402.1 - 0.062 13.6 0.0 0.078 13.2 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1612) NdhN PF11909.8 ETO36402.1 - 0.069 12.8 0.1 0.097 12.3 0.1 1.2 1 0 0 1 1 1 0 NADH-quinone oxidoreductase cyanobacterial subunit N DED PF01335.21 ETO36402.1 - 0.33 11.3 4.9 3.2 8.1 0.9 2.4 1 1 1 2 2 2 0 Death effector domain FSAP_sig_propep PF03032.15 ETO36404.1 - 0.13 12.3 0.4 0.13 12.3 0.4 2.0 2 0 0 2 2 2 0 Frog skin active peptide family signal and propeptide Gastrin PF00918.17 ETO36404.1 - 0.45 11.5 5.2 0.76 10.7 5.2 1.4 1 0 0 1 1 1 0 Gastrin/cholecystokinin family NPR3 PF03666.13 ETO36404.1 - 0.8 8.4 20.7 1.1 7.9 20.7 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 SLC12 PF03522.15 ETO36404.1 - 1.6 7.6 16.1 2 7.3 16.1 1.1 1 0 0 1 1 1 0 Solute carrier family 12 SRP-alpha_N PF04086.13 ETO36404.1 - 1.8 8.4 23.9 2.1 8.2 23.9 1.2 1 0 0 1 1 1 0 Signal recognition particle, alpha subunit, N-terminal CDC45 PF02724.14 ETO36404.1 - 3.4 5.9 14.8 4.4 5.5 14.8 1.2 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO36404.1 - 3.5 6.3 14.2 4.3 6.0 14.2 1.2 1 0 0 1 1 1 0 Presenilin MCM_bind PF09739.9 ETO36404.1 - 3.9 5.8 13.1 5.1 5.4 13.1 1.2 1 0 0 1 1 1 0 Mini-chromosome maintenance replisome factor Ndc1_Nup PF09531.10 ETO36404.1 - 4.2 5.9 14.8 4.6 5.8 14.8 1.0 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup RNase_HII PF01351.18 ETO36405.1 - 1.5e-18 67.3 0.0 2.2e-18 66.8 0.0 1.3 1 1 0 1 1 1 1 Ribonuclease HII DUF998 PF06197.13 ETO36406.1 - 0.039 13.6 0.0 0.039 13.6 0.0 2.9 3 0 0 3 3 3 0 Protein of unknown function (DUF998) DUF5527 PF17665.1 ETO36406.1 - 0.31 10.6 0.0 0.31 10.6 0.0 1.6 2 0 0 2 2 2 0 Family of unknown function (DUF5527) OST-HTH PF12872.7 ETO36407.1 - 0.14 12.0 0.0 0.39 10.6 0.0 1.7 1 0 0 1 1 1 0 OST-HTH/LOTUS domain WD40 PF00400.32 ETO36409.1 - 1.9e-15 57.0 7.6 7.5e-08 32.9 0.9 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36409.1 - 8.5e-05 22.8 0.2 0.0014 18.9 0.1 2.0 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36409.1 - 0.0001 21.1 1.1 0.014 14.0 0.2 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36409.1 - 0.00019 20.9 0.8 0.00025 20.5 0.8 1.3 1 1 0 1 1 1 1 WD40-like domain Methyltransf_15 PF09445.10 ETO36410.1 - 4.9e-35 120.5 0.5 8.5e-35 119.8 0.5 1.4 1 0 0 1 1 1 1 RNA cap guanine-N2 methyltransferase Methyltransf_25 PF13649.6 ETO36410.1 - 1.3e-06 29.0 0.0 3.8e-06 27.5 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain Met_10 PF02475.16 ETO36410.1 - 8.2e-06 25.7 0.1 8.2e-06 25.7 0.1 1.9 2 1 0 2 2 1 1 Met-10+ like-protein UPF0020 PF01170.18 ETO36410.1 - 9.1e-06 25.5 0.5 0.0001 22.0 0.5 2.3 1 1 0 1 1 1 1 Putative RNA methylase family UPF0020 Methyltransf_31 PF13847.6 ETO36410.1 - 1.6e-05 24.7 0.3 4.7e-05 23.2 0.3 1.9 1 1 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO36410.1 - 0.00076 20.1 0.0 0.0021 18.7 0.0 1.8 1 0 0 1 1 1 1 Methyltransferase domain PrmA PF06325.13 ETO36410.1 - 0.0023 17.4 0.1 0.0023 17.4 0.1 2.8 3 0 0 3 3 2 1 Ribosomal protein L11 methyltransferase (PrmA) Cons_hypoth95 PF03602.15 ETO36410.1 - 0.017 14.8 0.0 0.054 13.1 0.0 1.9 1 0 0 1 1 1 0 Conserved hypothetical protein 95 MTS PF05175.14 ETO36410.1 - 0.019 14.5 0.0 0.019 14.5 0.0 2.1 3 0 0 3 3 2 0 Methyltransferase small domain Methyltransf_12 PF08242.12 ETO36410.1 - 0.025 15.3 6.0 2.3 9.0 0.0 3.0 3 0 0 3 3 3 0 Methyltransferase domain Methyltransf_18 PF12847.7 ETO36410.1 - 0.038 13.9 1.0 0.082 12.8 0.0 2.0 2 0 0 2 2 2 0 Methyltransferase domain Comm PF15957.5 ETO36410.1 - 0.045 14.1 0.8 0.045 14.1 0.8 2.2 2 1 0 2 2 1 0 Commissureless CSG2 PF16965.5 ETO36410.1 - 0.19 10.6 0.7 0.42 9.5 0.7 1.5 1 0 0 1 1 1 0 Ceramide synthase regulator CLN3 PF02487.17 ETO36410.1 - 0.24 10.4 0.4 0.55 9.2 0.4 1.5 1 0 0 1 1 1 0 CLN3 protein Serinc PF03348.15 ETO36410.1 - 0.25 10.2 1.8 0.4 9.6 1.8 1.3 1 0 0 1 1 1 0 Serine incorporator (Serinc) Secretin_N_2 PF07655.13 ETO36410.1 - 1 9.9 11.6 0.23 12.0 7.6 1.9 2 0 0 2 2 2 0 Secretin N-terminal domain DUF2809 PF10990.8 ETO36411.1 - 0.3 11.8 1.9 0.54 11.0 1.9 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2809) RHD3 PF05879.12 ETO36412.1 - 1e-09 37.2 1.5 3.4e-09 35.4 0.7 1.7 1 1 1 2 2 2 1 Root hair defective 3 GTP-binding protein (RHD3) LptF_LptG PF03739.14 ETO36412.1 - 0.0035 16.3 2.2 0.0047 15.8 2.2 1.3 1 0 0 1 1 1 1 Lipopolysaccharide export system permease LptF/LptG G-gamma PF00631.22 ETO36414.1 - 0.00084 19.3 0.2 0.0016 18.4 0.2 1.4 1 0 0 1 1 1 1 GGL domain Utp14 PF04615.13 ETO36416.1 - 0.0013 17.4 7.8 0.0013 17.4 7.8 2.4 1 1 1 2 2 2 1 Utp14 protein Sedlin_N PF04628.13 ETO36417.1 - 0.098 12.8 0.1 0.15 12.2 0.1 1.2 1 0 0 1 1 1 0 Sedlin, N-terminal conserved region Med21 PF11221.8 ETO36418.1 - 0.24 11.6 4.0 0.65 10.2 0.4 2.4 2 0 0 2 2 2 0 Subunit 21 of Mediator complex ORC_WH_C PF18137.1 ETO36418.1 - 0.29 11.2 4.1 1 9.4 1.0 2.5 2 1 0 2 2 2 0 Origin recognition complex winged helix C-terminal Secretin_N_2 PF07655.13 ETO36418.1 - 2.7 8.6 16.0 2.2 8.9 12.5 2.3 2 0 0 2 2 2 0 Secretin N-terminal domain P63C PF10546.9 ETO36419.1 - 0.13 12.9 2.3 15 6.3 0.0 3.6 3 1 0 3 3 3 0 P63C domain UCH PF00443.29 ETO36420.1 - 9.8e-20 71.1 0.0 2.4e-19 69.8 0.0 1.5 1 1 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO36420.1 - 7.6e-12 45.5 0.5 1e-11 45.0 0.5 1.1 1 0 0 1 1 1 1 Ubiquitin carboxyl-terminal hydrolase DUF1279 PF06916.13 ETO36420.1 - 0.043 14.4 0.1 0.081 13.5 0.1 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1279) CAP_GLY PF01302.25 ETO36423.1 - 6.6e-27 93.3 10.9 4e-13 49.2 1.2 2.3 2 0 0 2 2 2 2 CAP-Gly domain DUF966 PF06136.13 ETO36423.1 - 0.035 13.8 7.0 0.048 13.4 7.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF966) Atg14 PF10186.9 ETO36423.1 - 0.25 10.4 12.3 0.41 9.7 12.3 1.3 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 Zip PF02535.22 ETO36423.1 - 4.3 6.5 5.0 5.7 6.1 5.0 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Presenilin PF01080.17 ETO36423.1 - 6.2 5.5 10.9 8.1 5.1 10.9 1.2 1 0 0 1 1 1 0 Presenilin RGS PF00615.19 ETO36424.1 - 0.062 13.6 0.0 0.12 12.7 0.0 1.4 1 0 0 1 1 1 0 Regulator of G protein signaling domain Sod_Cu PF00080.20 ETO36425.1 - 6.7e-27 94.4 3.3 1.3e-17 64.2 1.3 2.2 2 0 0 2 2 2 2 Copper/zinc superoxide dismutase (SODC) Aminotran_5 PF00266.19 ETO36426.1 - 3.6e-25 88.7 0.0 4.7e-25 88.3 0.0 1.1 1 0 0 1 1 1 1 Aminotransferase class-V Herpes_gI PF01688.17 ETO36427.1 - 0.031 14.2 0.8 0.079 12.9 0.8 1.6 1 0 0 1 1 1 0 Alphaherpesvirus glycoprotein I SAM_adeno_trans PF01887.16 ETO36430.1 - 0.13 11.6 0.1 0.15 11.5 0.1 1.1 1 0 0 1 1 1 0 S-adenosyl-l-methionine hydroxide adenosyltransferase GhoS PF11080.8 ETO36430.1 - 0.26 11.3 1.7 0.23 11.5 0.2 1.7 2 0 0 2 2 2 0 Endoribonuclease GhoS DUF3997 PF13162.6 ETO36430.1 - 0.38 11.1 4.3 4.4 7.6 0.1 2.5 2 1 1 3 3 3 0 Protein of unknown function (DUF3997) DUF4834 PF16118.5 ETO36431.1 - 0.04 14.9 0.0 4.9 8.2 0.0 2.8 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) FAM176 PF14851.6 ETO36431.1 - 0.049 13.3 0.0 9 6.0 0.0 2.7 3 0 0 3 3 3 0 FAM176 family RPA43_OB PF17875.1 ETO36431.1 - 0.16 12.6 1.5 0.45 11.1 0.0 2.3 2 0 0 2 2 2 0 RPA43 OB domain in RNA Pol I Sarcoglycan_1 PF04790.13 ETO36431.1 - 0.51 9.6 0.0 0.51 9.6 0.0 2.3 2 0 0 2 2 2 0 Sarcoglycan complex subunit protein tRNA_edit PF04073.15 ETO36432.1 - 3.5e-22 78.8 0.0 5.3e-22 78.2 0.0 1.3 1 0 0 1 1 1 1 Aminoacyl-tRNA editing domain DMPK_coil PF08826.10 ETO36432.1 - 5.5e-06 26.4 1.4 5.5e-06 26.4 1.4 2.0 2 0 0 2 2 2 1 DMPK coiled coil domain like Snapin_Pallidin PF14712.6 ETO36432.1 - 0.001 19.4 8.5 0.084 13.3 2.2 2.5 1 1 1 2 2 2 2 Snapin/Pallidin Spc24 PF08286.11 ETO36432.1 - 0.0036 17.5 4.5 0.0037 17.5 2.2 2.1 1 1 1 2 2 2 1 Spc24 subunit of Ndc80 Spc7 PF08317.11 ETO36432.1 - 0.0056 15.6 3.5 0.0095 14.8 3.5 1.3 1 0 0 1 1 1 1 Spc7 kinetochore protein Atg14 PF10186.9 ETO36432.1 - 0.0064 15.6 1.9 0.0098 15.0 1.9 1.4 1 0 0 1 1 1 1 Vacuolar sorting 38 and autophagy-related subunit 14 DUF2408 PF10303.9 ETO36432.1 - 0.0077 16.8 0.5 0.02 15.5 0.5 1.8 1 0 0 1 1 1 1 Protein of unknown function (DUF2408) bZIP_1 PF00170.21 ETO36432.1 - 0.0091 16.1 2.1 0.18 11.9 0.7 2.6 2 0 0 2 2 2 1 bZIP transcription factor DUF5082 PF16888.5 ETO36432.1 - 0.014 15.7 3.0 0.057 13.7 3.0 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF5082) DivIC PF04977.15 ETO36432.1 - 0.015 15.1 2.9 0.081 12.7 1.1 2.4 2 0 0 2 2 2 0 Septum formation initiator Prefoldin PF02996.17 ETO36432.1 - 0.016 15.2 4.6 0.99 9.3 1.2 2.5 1 1 1 2 2 2 0 Prefoldin subunit NPV_P10 PF05531.12 ETO36432.1 - 0.018 15.5 3.5 0.053 14.0 1.4 2.6 2 0 0 2 2 2 0 Nucleopolyhedrovirus P10 protein Tropomyosin_1 PF12718.7 ETO36432.1 - 0.025 14.7 1.8 0.025 14.7 1.8 1.9 2 0 0 2 2 2 0 Tropomyosin like Cnn_1N PF07989.11 ETO36432.1 - 0.034 14.3 2.0 0.16 12.2 1.9 2.2 1 1 0 1 1 1 0 Centrosomin N-terminal motif 1 Med10 PF09748.9 ETO36432.1 - 0.034 14.1 3.2 0.1 12.5 0.8 2.3 1 1 1 2 2 2 0 Transcription factor subunit Med10 of Mediator complex DUF5344 PF17279.2 ETO36432.1 - 0.045 14.3 2.1 0.14 12.8 1.0 2.3 1 1 1 2 2 2 0 Family of unknown function (DUF5344) RTBV_P12 PF06361.11 ETO36432.1 - 0.092 13.1 0.3 8.5 6.8 0.1 2.5 1 1 1 2 2 2 0 Rice tungro bacilliform virus P12 protein DUF262 PF03235.14 ETO36432.1 - 0.1 12.7 3.9 0.21 11.7 3.9 1.4 1 0 0 1 1 1 0 Protein of unknown function DUF262 Glu_synthase PF01645.17 ETO36432.1 - 0.12 11.4 0.3 0.19 10.8 0.3 1.2 1 0 0 1 1 1 0 Conserved region in glutamate synthase AKNA PF12443.8 ETO36432.1 - 0.14 12.8 4.4 1.1 10.0 0.5 2.6 3 0 0 3 3 2 0 AT-hook-containing transcription factor DUF2730 PF10805.8 ETO36432.1 - 0.21 11.7 2.3 1.4 9.1 0.3 2.7 1 1 1 2 2 2 0 Protein of unknown function (DUF2730) Mis12 PF05859.12 ETO36432.1 - 0.22 11.6 5.5 2.1 8.4 0.1 3.1 3 1 1 4 4 4 0 Mis12 protein Fib_alpha PF08702.10 ETO36432.1 - 0.22 11.7 3.6 0.5 10.5 3.6 1.6 1 0 0 1 1 1 0 Fibrinogen alpha/beta chain family MerR-DNA-bind PF09278.11 ETO36432.1 - 0.29 11.7 2.9 6.7 7.3 0.1 2.5 2 0 0 2 2 2 0 MerR, DNA binding bZIP_2 PF07716.15 ETO36432.1 - 0.3 11.2 7.6 0.2 11.8 2.0 2.5 2 0 0 2 2 2 0 Basic region leucine zipper DUF1664 PF07889.12 ETO36432.1 - 0.32 11.0 2.8 2 8.5 2.8 2.2 1 1 0 1 1 1 0 Protein of unknown function (DUF1664) Shugoshin_N PF07558.11 ETO36432.1 - 0.4 10.6 5.1 0.35 10.8 0.8 2.4 2 0 0 2 2 2 0 Shugoshin N-terminal coiled-coil region CENP-H PF05837.12 ETO36432.1 - 0.48 10.9 5.3 0.42 11.0 3.5 1.8 1 1 0 1 1 1 0 Centromere protein H (CENP-H) Ax_dynein_light PF10211.9 ETO36432.1 - 0.51 10.3 5.9 1.3 8.9 5.9 1.8 1 1 0 1 1 1 0 Axonemal dynein light chain GIT_CC PF16559.5 ETO36432.1 - 0.59 10.0 6.2 0.18 11.7 1.3 2.4 2 0 0 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor Fzo_mitofusin PF04799.13 ETO36432.1 - 1.4 8.5 4.9 1.9 8.0 1.7 2.5 2 1 1 3 3 3 0 fzo-like conserved region Nup54 PF13874.6 ETO36432.1 - 2.2 8.4 7.1 17 5.5 5.7 2.8 2 1 0 2 2 2 0 Nucleoporin complex subunit 54 YabA PF06156.13 ETO36432.1 - 2.5 8.8 9.1 0.12 13.1 1.4 2.6 3 1 0 3 3 3 0 Initiation control protein YabA FlxA PF14282.6 ETO36432.1 - 2.9 7.9 7.8 2.1 8.4 3.2 2.4 1 1 1 2 2 2 0 FlxA-like protein DUF4795 PF16043.5 ETO36432.1 - 4 7.0 9.4 1.9 8.0 3.3 2.2 2 1 1 3 3 3 0 Domain of unknown function (DUF4795) ABC_tran PF00005.27 ETO36433.1 - 6.2e-24 85.1 0.0 9.5e-24 84.5 0.0 1.3 1 0 0 1 1 1 1 ABC transporter ABC_membrane PF00664.23 ETO36433.1 - 1.3e-11 44.6 2.5 1.8e-11 44.2 2.5 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region SMC_N PF02463.19 ETO36433.1 - 0.017 14.6 0.8 0.43 10.0 0.1 2.1 1 1 1 2 2 2 0 RecF/RecN/SMC N terminal domain ABC_ATPase PF09818.9 ETO36433.1 - 0.052 12.3 0.1 0.073 11.8 0.1 1.1 1 0 0 1 1 1 0 Predicted ATPase of the ABC class AAA_29 PF13555.6 ETO36433.1 - 0.16 11.7 0.0 0.86 9.4 0.0 2.1 2 0 0 2 2 2 0 P-loop containing region of AAA domain ABC_membrane PF00664.23 ETO36434.1 - 1.1e-07 31.8 1.0 8.6e-06 25.6 1.1 2.3 2 1 0 2 2 2 2 ABC transporter transmembrane region DUF308 PF03729.13 ETO36434.1 - 2 8.8 10.1 0.65 10.4 4.5 2.7 3 1 0 3 3 3 0 Short repeat of unknown function (DUF308) WD40 PF00400.32 ETO36436.1 - 2.7e-06 28.0 1.6 0.011 16.6 0.3 2.8 2 1 0 2 2 2 2 WD domain, G-beta repeat PTEN_C2 PF10409.9 ETO36437.1 - 0.063 13.0 0.3 0.14 11.9 0.3 1.6 1 1 0 1 1 1 0 C2 domain of PTEN tumour-suppressor protein WD40 PF00400.32 ETO36438.1 - 2.8e-26 91.3 21.7 4e-07 30.6 0.5 7.1 6 1 0 6 6 6 6 WD domain, G-beta repeat Nup160 PF11715.8 ETO36438.1 - 3.9e-08 32.4 4.7 0.019 13.6 1.0 4.5 2 2 0 4 4 4 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36438.1 - 2.1e-07 31.1 0.6 1 9.7 0.0 4.9 4 1 1 5 5 5 2 Anaphase-promoting complex subunit 4 WD40 domain Phytoreo_S7 PF07236.11 ETO36438.1 - 0.1 10.9 2.4 0.19 10.0 2.4 1.3 1 0 0 1 1 1 0 Phytoreovirus S7 protein YL1 PF05764.13 ETO36439.1 - 0.046 13.8 2.0 0.062 13.4 1.7 1.3 1 1 0 1 1 1 0 YL1 nuclear protein Inos-1-P_synth PF01658.17 ETO36439.1 - 0.13 12.5 2.0 0.48 10.7 2.0 1.9 1 1 0 1 1 1 0 Myo-inositol-1-phosphate synthase 14-3-3 PF00244.20 ETO36440.1 - 3.7e-75 252.2 5.9 1.6e-46 158.6 1.1 2.3 2 1 0 2 2 2 2 14-3-3 protein TPR_12 PF13424.6 ETO36440.1 - 0.023 14.9 0.3 5.8 7.3 0.0 2.8 2 1 1 3 3 3 0 Tetratricopeptide repeat CelTOS PF18659.1 ETO36440.1 - 0.088 13.2 0.4 0.48 10.9 0.5 2.1 1 1 1 2 2 2 0 Cell-traversal protein for ookinetes and sporozoites TPR_8 PF13181.6 ETO36440.1 - 0.1 12.9 3.2 0.93 9.9 0.3 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat TetR_C_37 PF18665.1 ETO36440.1 - 0.24 12.0 5.2 0.13 12.8 2.7 1.9 2 0 0 2 2 2 0 Tetracyclin repressor-like, C-terminal domain TPR_2 PF07719.17 ETO36440.1 - 5.3 7.4 5.7 5.2 7.4 0.9 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat ATP_bind_3 PF01171.20 ETO36441.1 - 4.7e-23 81.9 0.9 1.1e-11 44.8 0.0 3.4 2 1 1 3 3 3 3 PP-loop family tRNA_Me_trans PF03054.16 ETO36441.1 - 0.011 14.5 0.0 0.021 13.6 0.0 1.3 1 0 0 1 1 1 0 tRNA methyl transferase SR-25 PF10500.9 ETO36441.1 - 0.018 14.7 9.6 0.043 13.4 9.6 1.6 1 0 0 1 1 1 0 Nuclear RNA-splicing-associated protein Secretin_N_2 PF07655.13 ETO36441.1 - 0.75 10.4 30.4 0.25 11.9 4.8 2.8 3 0 0 3 3 3 0 Secretin N-terminal domain Pep1_7 PF17232.2 ETO36441.1 - 0.77 10.3 9.4 0.21 12.1 3.5 2.5 2 0 0 2 2 2 0 Elicitor peptide 1-7 SDP_N PF12278.8 ETO36441.1 - 2.3 8.3 6.3 2.5 8.2 1.2 2.5 2 0 0 2 2 2 0 Sex determination protein N terminal IMUP PF15761.5 ETO36441.1 - 4.5 8.0 11.7 11 6.8 11.7 1.6 1 0 0 1 1 1 0 Immortalisation up-regulated protein G-alpha PF00503.20 ETO36442.1 - 2.7e-24 86.0 0.0 3.2e-24 85.8 0.0 1.1 1 0 0 1 1 1 1 G-protein alpha subunit Peroxin-22 PF12827.7 ETO36442.1 - 0.0068 16.3 0.0 0.011 15.7 0.0 1.3 1 0 0 1 1 1 1 Peroxisomal biogenesis protein family AAA_PrkA PF08298.11 ETO36442.1 - 0.13 11.1 0.0 0.19 10.6 0.0 1.2 1 0 0 1 1 1 0 PrkA AAA domain WD40 PF00400.32 ETO36443.1 - 3.3 8.7 0.0 3.3 8.7 0.0 3.9 4 1 0 4 4 4 0 WD domain, G-beta repeat DUF1353 PF07087.11 ETO36444.1 - 0.012 15.3 0.0 0.026 14.2 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1353) MAT1 PF06391.13 ETO36444.1 - 0.12 12.2 16.6 0.18 11.6 16.6 1.3 1 0 0 1 1 1 0 CDK-activating kinase assembly factor MAT1 GREB1 PF15782.5 ETO36444.1 - 0.27 8.3 11.0 0.34 8.0 11.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CDC45 PF02724.14 ETO36444.1 - 0.67 8.2 13.6 0.9 7.7 13.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Band_3_cyto PF07565.13 ETO36444.1 - 1.2 8.9 6.4 1.8 8.3 6.4 1.4 1 0 0 1 1 1 0 Band 3 cytoplasmic domain Macoilin PF09726.9 ETO36444.1 - 2.1 6.8 14.0 2.3 6.7 14.0 1.1 1 0 0 1 1 1 0 Macoilin family SLC12 PF03522.15 ETO36444.1 - 6.9 5.6 13.1 9.1 5.2 13.1 1.2 1 0 0 1 1 1 0 Solute carrier family 12 Pkinase PF00069.25 ETO36446.1 - 0.00099 18.5 0.2 0.0021 17.5 0.0 1.6 2 0 0 2 2 2 1 Protein kinase domain Presenilin PF01080.17 ETO36446.1 - 9.3 4.9 6.3 9.9 4.8 6.3 1.1 1 0 0 1 1 1 0 Presenilin Colicin_V PF02674.16 ETO36447.1 - 0.047 13.7 2.0 0.07 13.1 2.0 1.4 1 1 0 1 1 1 0 Colicin V production protein NUDIX PF00293.28 ETO36449.1 - 0.017 15.1 0.0 0.034 14.2 0.0 1.5 1 0 0 1 1 1 0 NUDIX domain Neur_chan_memb PF02932.16 ETO36450.1 - 0.019 15.0 2.7 0.12 12.4 0.5 2.3 2 0 0 2 2 2 0 Neurotransmitter-gated ion-channel transmembrane region DUF3300 PF11737.8 ETO36450.1 - 0.022 14.3 0.8 0.06 12.9 0.8 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF3300) DUF1911 PF08929.10 ETO36450.1 - 0.042 14.6 3.0 0.22 12.3 3.0 2.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1911) Gp-FAR-1 PF05823.12 ETO36450.1 - 0.068 13.5 2.6 0.12 12.7 2.6 1.4 1 0 0 1 1 1 0 Nematode fatty acid retinoid binding protein (Gp-FAR-1) Vfa1 PF08432.10 ETO36450.1 - 6.3 7.1 13.7 5.6 7.3 5.1 2.4 2 0 0 2 2 2 0 AAA-ATPase Vps4-associated protein 1 Trypan_glycop_C PF10659.9 ETO36450.1 - 6.7 7.2 12.1 1.7 9.1 4.0 2.8 2 0 0 2 2 2 0 Trypanosome variant surface glycoprotein C-terminal domain ANAPC4 PF12896.7 ETO36453.1 - 0.00049 19.6 0.6 0.00049 19.6 0.6 1.5 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 ANAPC4 PF12896.7 ETO36454.1 - 0.0012 18.4 0.2 0.0027 17.2 0.0 1.6 2 0 0 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 4 DAG1 PF05454.11 ETO36455.1 - 0.00042 19.8 0.1 0.00052 19.5 0.1 1.1 1 0 0 1 1 1 1 Dystroglycan (Dystrophin-associated glycoprotein 1) LRR19-TM PF15176.6 ETO36455.1 - 0.0017 18.3 0.4 0.0017 18.3 0.4 1.7 2 0 0 2 2 2 1 Leucine-rich repeat family 19 TM domain Protocadherin PF08374.11 ETO36455.1 - 0.0027 17.7 0.1 0.0038 17.2 0.1 1.3 1 0 0 1 1 1 1 Protocadherin LapA_dom PF06305.11 ETO36455.1 - 0.0032 17.3 0.0 0.0065 16.3 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide assembly protein A domain TMEM154 PF15102.6 ETO36455.1 - 0.004 17.1 4.1 0.0059 16.5 4.1 1.6 1 1 0 1 1 1 1 TMEM154 protein family m04gp34like PF12216.8 ETO36455.1 - 0.0049 16.5 1.4 0.008 15.8 1.3 1.4 1 1 0 1 1 1 1 Immune evasion protein Herpes_gE PF02480.16 ETO36455.1 - 0.0068 15.2 0.0 0.0083 14.9 0.0 1.1 1 0 0 1 1 1 1 Alphaherpesvirus glycoprotein E Sigma_reg_N PF13800.6 ETO36455.1 - 0.035 14.4 1.0 0.079 13.3 1.0 1.6 1 0 0 1 1 1 0 Sigma factor regulator N-terminal MLANA PF14991.6 ETO36455.1 - 0.037 14.3 0.0 0.075 13.3 0.0 1.5 1 0 0 1 1 1 0 Protein melan-A EphA2_TM PF14575.6 ETO36455.1 - 0.038 14.9 0.1 0.077 13.9 0.1 1.5 1 0 0 1 1 1 0 Ephrin type-A receptor 2 transmembrane domain DUF4448 PF14610.6 ETO36455.1 - 0.044 13.6 0.1 0.061 13.1 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF4448) DUF5527 PF17665.1 ETO36455.1 - 0.049 13.2 0.0 0.089 12.3 0.0 1.4 1 0 0 1 1 1 0 Family of unknown function (DUF5527) Amnionless PF14828.6 ETO36455.1 - 0.06 12.2 0.0 0.071 11.9 0.0 1.1 1 0 0 1 1 1 0 Amnionless DUF1180 PF06679.12 ETO36455.1 - 0.07 13.5 0.0 0.082 13.3 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1180) DUF4446 PF14584.6 ETO36455.1 - 0.082 12.9 0.7 0.14 12.1 0.2 1.7 2 0 0 2 2 2 0 Protein of unknown function (DUF4446) SLAC1 PF03595.17 ETO36455.1 - 0.16 11.2 2.4 0.37 10.0 0.7 1.9 1 1 0 2 2 2 0 Voltage-dependent anion channel DUF3827 PF12877.7 ETO36455.1 - 0.2 10.0 1.8 0.28 9.5 1.8 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3827) Pox_EPC_I2-L1 PF12575.8 ETO36455.1 - 0.31 11.3 2.0 0.47 10.7 0.4 2.1 2 0 0 2 2 2 0 Poxvirus entry protein complex L1 and I2 DUF3139 PF11337.8 ETO36455.1 - 0.84 10.3 5.2 27 5.5 4.6 2.3 1 1 1 2 2 2 0 Protein of unknown function (DUF3139) Synaptobrevin PF00957.21 ETO36455.1 - 1 9.2 4.7 0.35 10.7 1.1 2.0 2 0 0 2 2 2 0 Synaptobrevin Orf78 PF06024.12 ETO36455.1 - 4.3 7.7 6.0 2.8 8.3 4.1 1.8 1 1 0 1 1 1 0 Orf78 (ac78) SPT_ssu-like PF11779.8 ETO36457.1 - 0.17 11.5 4.8 4 7.1 1.2 2.7 2 0 0 2 2 2 0 Small subunit of serine palmitoyltransferase-like Mito_fiss_reg PF05308.11 ETO36460.1 - 0.29 11.2 34.9 2.3 8.2 4.5 3.7 3 0 0 3 3 3 0 Mitochondrial fission regulator Presenilin PF01080.17 ETO36461.1 - 0.05 12.4 7.6 0.069 11.9 7.6 1.2 1 0 0 1 1 1 0 Presenilin IFT43 PF15305.6 ETO36461.1 - 0.074 13.2 0.1 0.074 13.2 0.1 2.8 3 0 0 3 3 3 0 Intraflagellar transport protein 43 Striatin PF08232.12 ETO36461.1 - 0.096 13.3 10.1 2.1 9.0 0.4 2.5 2 0 0 2 2 2 0 Striatin family Ctr PF04145.15 ETO36461.1 - 1.4 9.6 6.4 3.5 8.3 0.3 2.6 3 0 0 3 3 3 0 Ctr copper transporter family NST1 PF13945.6 ETO36461.1 - 2.2 8.4 28.5 0.7 10.0 13.8 2.6 3 0 0 3 3 3 0 Salt tolerance down-regulator DUF1387 PF07139.11 ETO36461.1 - 3.6 7.2 16.5 0.22 11.2 11.5 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1387) POX PF07526.11 ETO36461.1 - 3.8 8.1 16.8 0.24 12.0 1.0 2.6 2 1 0 2 2 2 0 Associated with HOX DUF3362 PF11842.8 ETO36461.1 - 8.3 6.7 12.8 0.36 11.1 2.5 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF3362) CH_2 PF06294.11 ETO36462.1 - 0.082 13.0 0.0 0.1 12.7 0.0 1.2 1 0 0 1 1 1 0 CH-like domain in sperm protein PRK PF00485.18 ETO36463.1 - 2.7e-06 27.3 0.0 0.047 13.4 0.0 2.2 2 0 0 2 2 2 2 Phosphoribulokinase / Uridine kinase family DnaJ PF00226.31 ETO36464.1 - 5.4e-09 36.0 2.0 0.00072 19.6 0.2 2.9 1 1 1 2 2 2 2 DnaJ domain EF-hand_14 PF17959.1 ETO36464.1 - 0.02 15.2 0.5 0.02 15.2 0.5 3.4 2 1 1 3 3 3 0 EF-hand domain zf-C2H2_2 PF12756.7 ETO36464.1 - 0.53 10.6 5.1 1.6 9.1 0.3 3.2 2 0 0 2 2 2 0 C2H2 type zinc-finger (2 copies) adh_short PF00106.25 ETO36465.1 - 2.2e-43 148.0 0.5 2.6e-43 147.8 0.5 1.0 1 0 0 1 1 1 1 short chain dehydrogenase adh_short_C2 PF13561.6 ETO36465.1 - 2.1e-33 115.9 0.0 2.7e-33 115.5 0.0 1.0 1 0 0 1 1 1 1 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO36465.1 - 7.2e-11 42.3 0.1 1e-10 41.8 0.1 1.1 1 0 0 1 1 1 1 KR domain Epimerase PF01370.21 ETO36465.1 - 0.00079 19.0 0.1 0.00094 18.7 0.1 1.2 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family DapB_N PF01113.20 ETO36465.1 - 0.049 13.8 0.1 0.08 13.1 0.1 1.4 1 0 0 1 1 1 0 Dihydrodipicolinate reductase, N-terminus Peptidase_U57 PF05582.12 ETO36465.1 - 0.053 12.8 0.1 0.07 12.4 0.1 1.1 1 0 0 1 1 1 0 YabG peptidase U57 3Beta_HSD PF01073.19 ETO36465.1 - 0.053 12.5 1.1 0.072 12.1 1.1 1.3 1 1 0 1 1 1 0 3-beta hydroxysteroid dehydrogenase/isomerase family Glycos_transf_1 PF00534.20 ETO36466.1 - 0.049 13.2 3.3 0.078 12.5 3.3 1.3 1 0 0 1 1 1 0 Glycosyl transferases group 1 WD40 PF00400.32 ETO36466.1 - 0.065 14.1 1.9 0.1 13.5 0.5 2.1 2 0 0 2 2 2 0 WD domain, G-beta repeat Cyc-maltodext_N PF09087.11 ETO36466.1 - 0.62 10.4 6.0 0.19 12.0 1.7 2.1 1 1 1 2 2 2 0 Cyclomaltodextrinase, N-terminal DUF3687 PF12459.8 ETO36467.1 - 0.062 12.8 1.7 0.13 11.8 1.7 1.5 1 0 0 1 1 1 0 D-Ala-teichoic acid biosynthesis protein HEPN_AbiV PF18728.1 ETO36468.1 - 0.048 13.8 0.2 0.061 13.5 0.2 1.2 1 0 0 1 1 1 0 AbiV zf-TRAF PF02176.18 ETO36470.1 - 0.0066 17.1 5.8 0.0066 17.1 5.8 2.6 2 0 0 2 2 2 1 TRAF-type zinc finger DUF3629 PF12302.8 ETO36470.1 - 0.028 13.9 2.1 0.047 13.1 2.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3629) DUF2203 PF09969.9 ETO36470.1 - 1 10.1 6.0 9.5 7.0 6.0 2.2 1 1 0 1 1 1 0 Uncharacterized conserved protein (DUF2203) CENP-H PF05837.12 ETO36470.1 - 1.1 9.7 12.5 2.9 8.3 12.6 1.7 1 1 0 1 1 1 0 Centromere protein H (CENP-H) PKcGMP_CC PF16808.5 ETO36470.1 - 1.9 8.4 17.0 0.55 10.1 6.5 3.4 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase FapA PF03961.13 ETO36470.1 - 4.4 5.8 10.9 6.2 5.3 10.9 1.2 1 0 0 1 1 1 0 Flagellar Assembly Protein A DegT_DnrJ_EryC1 PF01041.17 ETO36472.1 - 0.028 13.8 0.0 0.036 13.4 0.0 1.1 1 0 0 1 1 1 0 DegT/DnrJ/EryC1/StrS aminotransferase family zf-RING_2 PF13639.6 ETO36473.1 - 1.4e-06 28.5 5.8 1.4e-06 28.5 5.8 2.1 2 0 0 2 2 2 1 Ring finger domain SWIM PF04434.17 ETO36473.1 - 9.2e-05 22.0 0.2 0.00018 21.1 0.2 1.5 1 0 0 1 1 1 1 SWIM zinc finger zf-ANAPC11 PF12861.7 ETO36473.1 - 0.0005 20.1 3.0 0.0013 18.8 3.0 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger PHD PF00628.29 ETO36473.1 - 0.0012 18.7 9.5 0.003 17.4 9.5 1.7 1 0 0 1 1 1 1 PHD-finger FANCL_C PF11793.8 ETO36473.1 - 0.002 18.3 4.4 0.0053 16.9 4.4 1.8 1 0 0 1 1 1 1 FANCL C-terminal domain zf-RING_4 PF14570.6 ETO36473.1 - 0.0046 16.7 6.2 0.012 15.4 6.2 1.8 1 0 0 1 1 1 1 RING/Ubox like zinc-binding domain zf-RING_UBOX PF13445.6 ETO36473.1 - 0.0058 16.6 2.8 0.015 15.3 2.8 1.8 1 0 0 1 1 1 1 RING-type zinc-finger RR_TM4-6 PF06459.12 ETO36473.1 - 0.079 12.8 14.2 0.15 11.9 14.2 1.4 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 zf-C3HC4_2 PF13923.6 ETO36473.1 - 0.32 10.9 5.9 0.14 12.0 2.2 2.4 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) C1_1 PF00130.22 ETO36473.1 - 0.41 10.6 8.8 0.16 11.9 5.0 2.2 1 1 1 2 2 2 0 Phorbol esters/diacylglycerol binding domain (C1 domain) zf-C3HC4 PF00097.25 ETO36473.1 - 1.9 8.4 6.5 6.2 6.8 6.5 2.0 1 0 0 1 1 1 0 Zinc finger, C3HC4 type (RING finger) Ndc1_Nup PF09531.10 ETO36473.1 - 7.8 5.0 9.9 11 4.6 9.9 1.1 1 0 0 1 1 1 0 Nucleoporin protein Ndc1-Nup CAP PF00188.26 ETO36474.1 - 2.3e-07 31.7 0.1 5.2e-07 30.5 0.1 1.6 1 0 0 1 1 1 1 Cysteine-rich secretory protein family PT PF04886.12 ETO36474.1 - 2.5e-05 23.7 25.2 9.5e-05 21.9 3.7 3.4 2 1 1 3 3 3 2 PT repeat DUF4106 PF13388.6 ETO36474.1 - 0.0086 15.4 2.0 0.015 14.6 2.0 1.3 1 0 0 1 1 1 1 Protein of unknown function (DUF4106) MobA_MobL PF03389.15 ETO36475.1 - 0.029 14.1 0.0 0.041 13.6 0.0 1.2 1 0 0 1 1 1 0 MobA/MobL family MMR_HSR1 PF01926.23 ETO36475.1 - 0.14 12.3 0.0 0.31 11.1 0.0 1.7 1 1 0 1 1 1 0 50S ribosome-binding GTPase DUF4760 PF15956.5 ETO36477.1 - 0.0089 16.2 1.4 0.016 15.3 0.7 1.7 1 1 0 2 2 2 1 Domain of unknown function (DUF4760) CLU PF13236.6 ETO36477.1 - 0.031 14.1 0.6 0.043 13.6 0.6 1.2 1 0 0 1 1 1 0 Clustered mitochondria NAD_binding_2 PF03446.15 ETO36477.1 - 0.16 12.1 0.0 0.22 11.7 0.0 1.2 1 0 0 1 1 1 0 NAD binding domain of 6-phosphogluconate dehydrogenase zf-RVT PF13966.6 ETO36478.1 - 0.00016 22.3 4.4 0.00016 22.3 4.4 3.2 2 1 1 3 3 3 1 zinc-binding in reverse transcriptase zf-CCHC PF00098.23 ETO36479.1 - 0.00029 20.8 1.7 0.00062 19.7 1.7 1.6 1 0 0 1 1 1 1 Zinc knuckle LRRFIP PF09738.9 ETO36480.1 - 0.048 13.1 0.2 0.057 12.9 0.2 1.1 1 0 0 1 1 1 0 LRRFIP family RVT_1 PF00078.27 ETO36481.1 - 9.3e-06 25.3 0.0 1.1e-05 25.1 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Carbpep_Y_N PF05388.11 ETO36483.1 - 0.073 13.6 0.8 0.25 11.9 0.1 2.1 1 1 0 2 2 2 0 Carboxypeptidase Y pro-peptide Dicty_CAD PF05720.12 ETO36484.1 - 0.015 15.3 0.0 0.035 14.1 0.0 1.6 1 0 0 1 1 1 0 Cell-cell adhesion domain FYVE_2 PF02318.16 ETO36485.1 - 0.028 14.6 1.2 0.028 14.6 1.2 1.9 1 1 1 2 2 2 0 FYVE-type zinc finger Cyt-b5 PF00173.28 ETO36486.1 - 2.6e-06 27.5 0.0 0.16 12.2 0.0 3.2 3 0 0 3 3 3 2 Cytochrome b5-like Heme/Steroid binding domain Cytomega_UL84 PF06284.11 ETO36487.1 - 0.46 8.9 5.5 0.47 8.9 5.5 1.1 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein Pox_Ag35 PF03286.14 ETO36487.1 - 0.58 9.9 17.3 0.67 9.7 17.3 1.1 1 0 0 1 1 1 0 Pox virus Ag35 surface protein Rhodanese PF00581.20 ETO36488.1 - 0.67 10.5 4.0 10 6.7 0.9 3.0 3 0 0 3 3 3 0 Rhodanese-like domain DUF1828 PF08861.10 ETO36488.1 - 1.5 9.1 6.6 0.43 10.9 0.7 2.7 2 0 0 2 2 2 0 Domain of unknown function DUF1828 SH3_1 PF00018.28 ETO36490.1 - 1.1e-09 37.8 0.0 2.4e-09 36.6 0.0 1.6 2 0 0 2 2 2 1 SH3 domain SH3_9 PF14604.6 ETO36490.1 - 9.4e-06 25.4 0.0 1.6e-05 24.7 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETO36490.1 - 0.0032 17.1 0.0 0.0057 16.3 0.0 1.4 1 0 0 1 1 1 1 Variant SH3 domain PLU-1 PF08429.11 ETO36491.1 - 0.00022 20.5 1.0 0.0005 19.3 0.6 1.7 1 1 0 1 1 1 1 PLU-1-like protein DUF5599 PF18141.1 ETO36492.1 - 0.021 15.0 1.0 0.12 12.6 0.1 2.7 2 2 1 3 3 3 0 Domain of unknown function (DUF5599) CtIP_N PF10482.9 ETO36493.1 - 0.16 12.0 3.7 0.2 11.7 0.9 2.1 1 1 1 2 2 2 0 Tumour-suppressor protein CtIP N-terminal domain F-box-like PF12937.7 ETO36494.1 - 0.0013 18.6 0.1 0.0024 17.7 0.1 1.5 1 0 0 1 1 1 1 F-box-like SPRY PF00622.28 ETO36495.1 - 3.9e-06 27.0 0.1 5.6e-06 26.5 0.1 1.3 1 0 0 1 1 1 1 SPRY domain UQ_con PF00179.26 ETO36496.1 - 0.0025 17.5 0.3 0.0038 16.9 0.3 1.3 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme TMEM164 PF14808.6 ETO36496.1 - 0.036 13.4 0.4 0.049 13.0 0.4 1.1 1 0 0 1 1 1 0 TMEM164 family TNFR_16_TM PF18422.1 ETO36498.1 - 0.1 12.6 0.1 0.25 11.3 0.1 1.7 1 0 0 1 1 1 0 Tumor necrosis factor receptor member 16 trans-membrane domain Nop14 PF04147.12 ETO36499.1 - 0.00046 18.6 15.4 0.00046 18.6 15.4 1.9 2 0 0 2 2 2 1 Nop14-like family EHN PF06441.12 ETO36499.1 - 1.3 9.4 7.3 0.33 11.3 3.2 2.1 2 0 0 2 2 2 0 Epoxide hydrolase N terminus SART-1 PF03343.13 ETO36501.1 - 4.5e-65 220.4 55.6 3.3e-30 105.3 15.6 3.6 3 1 0 3 3 3 3 SART-1 family SAM_2 PF07647.17 ETO36501.1 - 2.2e-05 24.5 0.0 5.2e-05 23.3 0.0 1.6 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_1 PF00536.30 ETO36501.1 - 3.4e-05 24.2 0.1 8.9e-05 22.9 0.1 1.8 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) YMF19 PF02326.15 ETO36501.1 - 0.051 14.4 5.2 5.1 7.9 0.4 4.3 3 1 0 3 3 3 0 Plant ATP synthase F0 OATP PF03137.20 ETO36501.1 - 0.15 10.3 0.0 0.15 10.3 0.0 2.9 2 2 1 4 4 4 0 Organic Anion Transporter Polypeptide (OATP) family OAD_gamma PF04277.13 ETO36501.1 - 0.31 11.6 5.8 4.8 7.9 0.4 4.1 4 1 0 4 4 4 0 Oxaloacetate decarboxylase, gamma chain CLN3 PF02487.17 ETO36501.1 - 2.6 7.0 9.9 15 4.5 0.0 3.5 3 1 1 4 4 4 0 CLN3 protein Tmemb_9 PF05434.11 ETO36501.1 - 5.1 7.0 9.3 4.6 7.1 1.6 3.5 3 0 0 3 3 3 0 TMEM9 DUF2206 PF09971.9 ETO36501.1 - 6 5.5 6.4 4.1 6.1 1.3 2.2 2 0 0 2 2 2 0 Predicted membrane protein (DUF2206) Aminotran_5 PF00266.19 ETO36502.1 - 9.9e-34 116.9 0.0 2.3e-33 115.7 0.0 1.7 1 1 0 1 1 1 1 Aminotransferase class-V ATP_bind_3 PF01171.20 ETO36502.1 - 3e-15 56.5 0.0 1.5e-14 54.1 0.0 2.2 2 1 0 2 2 2 1 PP-loop family Cys_Met_Meta_PP PF01053.20 ETO36502.1 - 0.0017 16.9 0.0 0.0029 16.2 0.0 1.2 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme CS PF04969.16 ETO36503.1 - 9e-15 55.5 0.1 9e-15 55.5 0.1 2.4 3 0 0 3 3 3 1 CS domain CDC45 PF02724.14 ETO36503.1 - 0.044 12.1 2.2 0.041 12.2 2.2 1.2 1 0 0 1 1 1 0 CDC45-like protein CUE PF02845.16 ETO36503.1 - 0.1 12.3 0.7 0.22 11.3 0.7 1.6 1 0 0 1 1 1 0 CUE domain Lsr2 PF11774.8 ETO36503.1 - 0.58 10.3 4.2 0.24 11.6 0.6 2.0 1 1 1 2 2 2 0 Lsr2 SieB PF14163.6 ETO36503.1 - 0.6 9.6 3.2 5.3 6.5 0.3 2.4 2 0 0 2 2 2 0 Super-infection exclusion protein B Dicty_REP PF05086.12 ETO36503.1 - 1.1 7.2 9.7 1.8 6.5 9.7 1.4 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein Presenilin PF01080.17 ETO36503.1 - 1.7 7.3 9.3 0.036 12.8 3.0 1.5 2 0 0 2 2 2 0 Presenilin Sec62 PF03839.16 ETO36503.1 - 9.8 5.6 17.5 2.7 7.4 11.3 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 DEAD PF00270.29 ETO36505.1 - 0.0021 17.9 0.0 0.0031 17.3 0.0 1.2 1 0 0 1 1 1 1 DEAD/DEAH box helicase AAA_29 PF13555.6 ETO36505.1 - 0.19 11.5 0.0 0.34 10.7 0.0 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain DUF2561 PF10812.8 ETO36506.1 - 0.051 13.6 0.3 0.7 9.9 0.0 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF2561) FAM60A PF15396.6 ETO36506.1 - 1.9 8.5 11.3 0.23 11.4 2.7 2.4 2 1 0 2 2 2 0 Protein Family FAM60A PRCH PF03967.13 ETO36506.1 - 5.8 7.2 5.5 8.8 6.6 0.8 2.6 2 0 0 2 2 2 0 Photosynthetic reaction centre, H-chain N-terminal region RuBisCo_chap_C PF18087.1 ETO36507.1 - 0.028 14.1 0.0 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Rubisco Assembly chaperone C-terminal domain PARP PF00644.20 ETO36507.1 - 0.057 13.0 1.7 0.93 9.0 1.6 2.5 1 1 0 1 1 1 0 Poly(ADP-ribose) polymerase catalytic domain ZapB PF06005.12 ETO36508.1 - 0.0002 21.7 33.2 0.0047 17.3 4.7 4.2 2 1 2 4 4 4 3 Cell division protein ZapB DUF1192 PF06698.11 ETO36508.1 - 0.0059 16.6 6.4 0.12 12.5 0.2 3.4 1 1 1 3 3 3 1 Protein of unknown function (DUF1192) ADIP PF11559.8 ETO36508.1 - 0.0084 16.2 19.1 0.0084 16.2 19.1 2.4 1 1 1 2 2 2 1 Afadin- and alpha -actinin-Binding Cnn_1N PF07989.11 ETO36508.1 - 0.024 14.8 24.8 0.034 14.3 9.5 3.5 2 2 1 3 3 3 0 Centrosomin N-terminal motif 1 Cep57_CLD_2 PF14197.6 ETO36508.1 - 0.042 13.9 7.1 0.042 13.9 7.1 4.0 3 1 1 4 4 4 0 Centrosome localisation domain of PPC89 Spc7 PF08317.11 ETO36508.1 - 0.051 12.5 23.7 0.045 12.6 22.9 1.3 1 1 0 1 1 1 0 Spc7 kinetochore protein TSC22 PF01166.18 ETO36508.1 - 0.069 13.5 15.5 1.7 9.0 1.6 3.6 2 1 1 3 3 3 0 TSC-22/dip/bun family Ax_dynein_light PF10211.9 ETO36508.1 - 0.095 12.6 23.4 0.18 11.7 7.9 2.5 1 1 1 2 2 2 0 Axonemal dynein light chain HAUS-augmin3 PF14932.6 ETO36508.1 - 0.11 12.0 28.8 0.19 11.3 27.8 1.7 1 1 0 1 1 1 0 HAUS augmin-like complex subunit 3 DUF4407 PF14362.6 ETO36508.1 - 0.32 10.3 18.1 0.41 10.0 18.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) KfrA_N PF11740.8 ETO36508.1 - 0.69 10.6 15.1 0.17 12.5 6.0 2.5 2 1 1 3 3 2 0 Plasmid replication region DNA-binding N-term FlaC_arch PF05377.11 ETO36508.1 - 0.79 10.2 18.2 1.7 9.1 0.1 3.7 3 1 1 4 4 3 0 Flagella accessory protein C (FlaC) DivIC PF04977.15 ETO36508.1 - 0.84 9.5 31.1 0.19 11.5 2.8 3.9 4 1 0 4 4 4 0 Septum formation initiator JIP_LZII PF16471.5 ETO36508.1 - 0.91 9.7 19.3 0.062 13.5 6.1 3.0 2 1 1 3 3 2 0 JNK-interacting protein leucine zipper II Rootletin PF15035.6 ETO36508.1 - 1.2 9.2 33.5 3 7.8 6.2 2.1 1 1 1 2 2 2 0 Ciliary rootlet component, centrosome cohesion HALZ PF02183.18 ETO36508.1 - 1.2 9.4 29.7 0.33 11.2 5.6 4.2 3 1 1 4 4 4 0 Homeobox associated leucine zipper DUF3552 PF12072.8 ETO36508.1 - 1.3 8.4 28.0 0.12 11.8 14.7 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF3552) DUF5320 PF17253.2 ETO36508.1 - 1.3 10.1 9.0 0.85 10.7 1.5 2.5 2 0 0 2 2 2 0 Family of unknown function (DUF5320) DUF2304 PF10066.9 ETO36508.1 - 1.3 9.3 5.7 1.5 9.1 1.3 2.3 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) Tropomyosin_1 PF12718.7 ETO36508.1 - 1.3 9.1 29.4 0.85 9.8 8.1 2.7 1 1 1 2 2 2 0 Tropomyosin like APG6_N PF17675.1 ETO36508.1 - 1.3 9.5 34.4 2.4 8.7 21.9 2.9 1 1 1 2 2 2 0 Apg6 coiled-coil region PRKG1_interact PF15898.5 ETO36508.1 - 2.1 9.3 33.7 2 9.4 9.6 3.1 1 1 2 3 3 3 0 cGMP-dependent protein kinase interacting domain Herpes_BLRF2 PF05812.12 ETO36508.1 - 2.2 8.4 16.1 0.68 10.1 2.1 3.2 1 1 2 3 3 3 0 Herpesvirus BLRF2 protein Spc24 PF08286.11 ETO36508.1 - 2.4 8.5 29.3 0.87 9.9 8.3 3.1 1 1 2 3 3 3 0 Spc24 subunit of Ndc80 Uso1_p115_C PF04871.13 ETO36508.1 - 3.2 8.1 33.2 2.1 8.7 15.3 2.6 2 1 0 2 2 2 0 Uso1 / p115 like vesicle tethering protein, C terminal region bZIP_Maf PF03131.17 ETO36508.1 - 5.6 7.5 25.1 14 6.3 4.6 2.7 1 1 1 2 2 2 0 bZIP Maf transcription factor Seadorna_VP6 PF07407.11 ETO36508.1 - 6.4 5.6 7.5 4.6 6.1 1.2 2.3 1 1 1 2 2 2 0 Seadornavirus VP6 protein bZIP_2 PF07716.15 ETO36508.1 - 7.3 6.8 43.1 0.29 11.2 4.7 4.3 4 1 1 5 5 3 0 Basic region leucine zipper CheR PF01739.18 ETO36509.1 - 0.009 15.5 0.2 0.13 11.7 0.0 2.1 2 0 0 2 2 2 2 CheR methyltransferase, SAM binding domain VPS9 PF02204.18 ETO36510.1 - 0.097 12.9 0.2 0.097 12.9 0.2 2.0 2 0 0 2 2 2 0 Vacuolar sorting protein 9 (VPS9) domain Macoilin PF09726.9 ETO36510.1 - 1.3 7.5 33.9 0.14 10.7 19.7 2.1 2 0 0 2 2 2 0 Macoilin family Zip PF02535.22 ETO36510.1 - 4 6.6 20.2 2 7.5 3.7 2.2 2 0 0 2 2 2 0 ZIP Zinc transporter PAP1 PF08601.10 ETO36510.1 - 6.7 6.3 41.5 0.072 12.8 30.5 2.1 2 0 0 2 2 2 0 Transcription factor PAP1 NA37 PF04245.13 ETO36511.1 - 0.015 14.8 0.5 0.02 14.4 0.5 1.3 1 1 0 1 1 1 0 37-kD nucleoid-associated bacterial protein DUF874 PF05917.11 ETO36511.1 - 0.021 13.9 1.3 0.025 13.6 1.3 1.2 1 0 0 1 1 1 0 Helicobacter pylori protein of unknown function (DUF874) Ribosomal_L18_c PF14204.6 ETO36511.1 - 0.025 15.5 0.9 0.035 15.0 0.8 1.5 1 1 0 1 1 1 0 Ribosomal L18 C-terminal region DUF2833 PF11090.8 ETO36511.1 - 0.07 13.5 0.2 0.16 12.4 0.2 1.7 1 0 0 1 1 1 0 Protein of unknown function (DUF2833) zf-C2H2_3rep PF18868.1 ETO36511.1 - 0.079 13.6 0.3 0.14 12.9 0.2 1.5 1 1 0 1 1 1 0 Zinc finger C2H2-type, 3 repeats DUF4168 PF13767.6 ETO36511.1 - 0.32 12.2 3.4 1.6 10.0 0.3 2.2 1 1 1 2 2 2 0 Domain of unknown function (DUF4168) DNA_pack_N PF02500.15 ETO36511.1 - 0.6 9.9 5.2 6.9 6.4 5.2 2.0 1 1 0 1 1 1 0 Probable DNA packing protein, N-terminus PNMA PF14893.6 ETO36512.1 - 0.081 12.3 0.3 0.13 11.6 0.3 1.3 1 0 0 1 1 1 0 PNMA DUF21 PF01595.20 ETO36513.1 - 7.2e-26 90.9 4.8 2.4e-24 86.0 4.8 2.1 1 1 0 1 1 1 1 Cyclin M transmembrane N-terminal domain ArAE_1 PF06081.11 ETO36513.1 - 0.051 13.7 0.3 0.12 12.5 0.3 1.7 1 0 0 1 1 1 0 Aromatic acid exporter family member 1 Imm70 PF15601.6 ETO36514.1 - 0.04 13.5 0.0 0.079 12.5 0.0 1.4 1 0 0 1 1 1 0 Immunity protein 70 YqbF PF14553.6 ETO36515.1 - 0.29 11.0 0.2 0.29 11.0 0.2 1.9 2 0 0 2 2 2 0 YqbF, hypothetical protein domain EAF PF09816.9 ETO36516.1 - 1.5e-06 28.5 0.0 1.5e-06 28.5 0.0 3.0 3 1 1 4 4 4 1 RNA polymerase II transcription elongation factor Surp PF01805.20 ETO36517.1 - 6.5e-12 45.3 0.8 1.4e-11 44.2 0.1 1.9 2 0 0 2 2 2 1 Surp module AAA_22 PF13401.6 ETO36518.1 - 0.029 14.6 0.0 0.086 13.1 0.0 1.8 1 1 0 1 1 1 0 AAA domain ATPase_2 PF01637.18 ETO36518.1 - 0.046 13.6 0.1 0.36 10.7 0.0 2.4 2 1 0 2 2 2 0 ATPase domain predominantly from Archaea AAA_14 PF13173.6 ETO36518.1 - 0.054 13.5 0.0 0.14 12.2 0.0 1.7 1 0 0 1 1 1 0 AAA domain RRM_1 PF00076.22 ETO36519.1 - 9.1e-09 35.0 0.0 0.0057 16.4 0.0 2.4 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) PKD PF00801.20 ETO36519.1 - 1.6 8.7 5.3 8 6.4 0.2 2.8 3 0 0 3 3 3 0 PKD domain Pkinase PF00069.25 ETO36520.1 - 2.3e-13 50.1 0.0 3.7e-13 49.4 0.0 1.4 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36520.1 - 4e-08 32.8 0.0 5.9e-08 32.3 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase Pkinase PF00069.25 ETO36521.1 - 9.2e-07 28.5 0.0 1.4e-06 27.9 0.0 1.4 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36521.1 - 0.0025 17.1 0.0 0.0036 16.6 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase ABC1 PF03109.16 ETO36521.1 - 0.016 15.3 0.0 0.031 14.4 0.0 1.5 1 1 0 1 1 1 0 ABC1 family LDB19 PF13002.7 ETO36522.1 - 0.07 12.8 0.1 0.16 11.7 0.1 1.6 1 0 0 1 1 1 0 Arrestin_N terminal like SQS_PSY PF00494.19 ETO36523.1 - 3e-29 102.3 0.1 4.4e-29 101.8 0.1 1.2 1 0 0 1 1 1 1 Squalene/phytoene synthase DUF908 PF06012.12 ETO36523.1 - 0.32 10.4 8.4 0.58 9.5 8.4 1.3 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Sigma_reg_N PF13800.6 ETO36523.1 - 4.9 7.5 7.0 0.42 10.9 1.6 2.0 2 0 0 2 2 2 0 Sigma factor regulator N-terminal WD40 PF00400.32 ETO36526.1 - 1.1e-19 70.3 14.2 2.3e-05 25.1 0.9 5.4 5 2 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36526.1 - 2.6e-06 27.6 2.4 0.97 9.8 0.1 4.0 2 1 2 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36526.1 - 1.2e-05 24.2 2.6 2.1 6.9 0.0 3.8 2 1 2 4 4 4 3 Nucleoporin Nup120/160 CDP-OH_P_transf PF01066.21 ETO36527.1 - 6.5e-11 42.8 0.0 6.5e-11 42.8 0.0 3.2 2 1 0 2 2 2 1 CDP-alcohol phosphatidyltransferase N_Asn_amidohyd PF14736.6 ETO36528.1 - 0.031 13.4 0.0 0.031 13.4 0.0 1.1 1 0 0 1 1 1 0 Protein N-terminal asparagine amidohydrolase Sec16 PF12932.7 ETO36528.1 - 0.1 13.2 0.1 0.11 13.1 0.1 1.1 1 0 0 1 1 1 0 Vesicle coat trafficking protein Sec16 mid-region SUIM_assoc PF16619.5 ETO36529.1 - 0.0046 17.0 1.2 0.0082 16.2 1.2 1.6 1 0 0 1 1 1 1 Unstructured region C-term to UIM in Ataxin3 Vps4_C PF09336.10 ETO36529.1 - 0.011 15.7 1.4 0.015 15.3 0.1 1.9 2 0 0 2 2 2 0 Vps4 C terminal oligomerisation domain DUF2971 PF11185.8 ETO36530.1 - 1.3 10.2 10.3 3.9 8.7 10.3 1.9 1 1 0 1 1 1 0 Protein of unknown function (DUF2971) TPK_catalytic PF04263.16 ETO36531.1 - 0.053 13.6 0.1 0.095 12.8 0.1 1.4 1 0 0 1 1 1 0 Thiamin pyrophosphokinase, catalytic domain WD40 PF00400.32 ETO36534.1 - 3.4e-18 65.6 5.2 1.9e-05 25.3 0.3 4.5 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36534.1 - 0.0008 19.7 0.2 0.85 10.0 0.0 3.2 3 0 0 3 3 3 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36534.1 - 0.022 13.4 0.3 4.8 5.7 0.0 2.5 1 1 2 3 3 3 0 Nucleoporin Nup120/160 Transposase_mut PF00872.18 ETO36535.1 - 8.8e-92 307.9 0.0 1e-91 307.6 0.0 1.0 1 0 0 1 1 1 1 Transposase, Mutator family MULE PF10551.9 ETO36535.1 - 7.5e-06 26.3 0.0 1.7e-05 25.2 0.0 1.6 1 0 0 1 1 1 1 MULE transposase domain NPV_P10 PF05531.12 ETO36536.1 - 0.17 12.4 19.0 1.8 9.1 0.5 4.3 4 0 0 4 4 4 0 Nucleopolyhedrovirus P10 protein DUF3685 PF12452.8 ETO36536.1 - 0.26 11.0 4.0 0.52 10.0 4.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF3685) DUF2722 PF10846.8 ETO36537.1 - 0.0034 16.4 7.1 0.0041 16.1 7.1 1.1 1 0 0 1 1 1 1 Protein of unknown function (DUF2722) BSP_II PF05432.11 ETO36537.1 - 0.015 15.0 6.4 0.019 14.6 6.4 1.2 1 0 0 1 1 1 0 Bone sialoprotein II (BSP-II) Sox_N PF12444.8 ETO36537.1 - 0.11 13.7 3.2 0.18 13.0 3.2 1.3 1 0 0 1 1 1 0 Sox developmental protein N terminal DUF4770 PF15994.5 ETO36537.1 - 0.16 12.2 4.3 0.19 11.9 4.3 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4770) FliX PF10768.9 ETO36537.1 - 0.19 12.2 3.1 0.21 12.1 3.1 1.1 1 0 0 1 1 1 0 Class II flagellar assembly regulator ORF6N PF10543.9 ETO36537.1 - 0.22 11.7 0.4 0.22 11.7 0.4 1.8 2 0 0 2 2 2 0 ORF6N domain Pannexin_like PF12534.8 ETO36537.1 - 0.22 10.5 2.3 0.21 10.6 2.3 1.1 1 0 0 1 1 1 0 Pannexin-like TM region of LRRC8 Red1 PF07964.11 ETO36537.1 - 0.31 9.3 11.9 0.33 9.2 11.9 1.0 1 0 0 1 1 1 0 Rec10 / Red1 Presenilin PF01080.17 ETO36537.1 - 0.59 8.8 3.7 0.57 8.9 3.7 1.1 1 0 0 1 1 1 0 Presenilin G-patch_2 PF12656.7 ETO36537.1 - 1.9 8.6 4.4 9.2 6.4 4.4 2.0 1 1 0 1 1 1 0 G-patch domain PTEN_C2 PF10409.9 ETO36538.1 - 5.4e-08 32.7 0.4 9.5e-08 31.9 0.4 1.6 1 0 0 1 1 1 1 C2 domain of PTEN tumour-suppressor protein Glyco_transf_34 PF05637.12 ETO36539.1 - 6.8e-05 22.7 0.0 9.3e-05 22.3 0.0 1.2 1 0 0 1 1 1 1 galactosyl transferase GMA12/MNN10 family Nudix_hydro PF18290.1 ETO36540.1 - 4.4e-23 81.1 0.2 9.2e-23 80.0 0.2 1.6 1 0 0 1 1 1 1 Nudix hydrolase domain NUDIX PF00293.28 ETO36540.1 - 8.2e-16 58.2 0.2 1.1e-06 28.7 0.0 2.5 2 0 0 2 2 2 2 NUDIX domain AAA_7 PF12775.7 ETO36543.1 - 0.0066 16.0 0.2 0.012 15.1 0.2 1.5 1 0 0 1 1 1 1 P-loop containing dynein motor region AAA PF00004.29 ETO36543.1 - 0.031 14.7 0.0 0.062 13.7 0.0 1.5 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) DUF2513 PF10711.9 ETO36543.1 - 0.042 14.1 1.0 0.28 11.5 0.2 2.3 1 1 1 2 2 2 0 Hypothetical protein (DUF2513) AAA_22 PF13401.6 ETO36543.1 - 0.052 13.8 0.1 0.9 9.8 0.0 2.2 1 1 1 2 2 2 0 AAA domain WD40 PF00400.32 ETO36546.1 - 5.9e-130 419.4 45.9 2.3e-09 37.7 0.3 15.1 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36546.1 - 5.6e-24 84.3 14.4 0.32 11.3 0.5 12.4 1 1 11 12 12 12 8 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36546.1 - 4.6e-21 75.1 1.8 1.8 7.5 0.0 12.9 1 1 12 14 14 14 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO36546.1 - 3.8e-17 62.1 25.3 0.036 12.7 0.7 12.3 2 2 9 12 12 12 7 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36546.1 - 1e-12 48.0 8.0 0.0092 15.3 0.0 7.2 2 1 5 8 8 8 3 WD40-like domain Str_synth PF03088.16 ETO36546.1 - 1.2e-09 38.2 0.7 0.36 11.0 0.0 7.8 5 3 3 8 8 8 1 Strictosidine synthase Mid2 PF04478.12 ETO36546.1 - 1.9e-06 27.8 3.5 4.2 7.2 0.0 6.8 7 1 2 9 9 9 1 Mid2 like cell wall stress sensor POLO_box PF00659.18 ETO36546.1 - 0.0004 20.5 6.7 1.3 9.2 0.1 6.6 7 3 1 8 8 7 1 POLO box duplicated region Cytochrom_D1 PF02239.16 ETO36546.1 - 0.0012 17.4 10.6 1.2 7.6 0.1 5.7 2 2 4 7 7 7 2 Cytochrome D1 heme domain DUF5570 PF17731.1 ETO36546.1 - 0.0013 18.8 7.9 17 5.5 0.1 7.9 5 2 4 10 10 10 0 Family of unknown function (DUF5570) PD40 PF07676.12 ETO36546.1 - 0.0043 17.0 15.1 11 6.1 0.0 8.3 10 0 0 10 10 10 1 WD40-like Beta Propeller Repeat DUF727 PF05303.12 ETO36546.1 - 0.01 15.9 0.7 23 5.1 0.0 5.0 5 1 1 6 6 6 0 Protein of unknown function (DUF727) Frtz PF11768.8 ETO36546.1 - 0.012 13.9 1.3 2.4 6.3 0.1 4.1 5 0 0 5 5 5 0 WD repeat-containing and planar cell polarity effector protein Fritz DPPIV_N PF00930.21 ETO36546.1 - 0.036 12.8 0.2 19 3.9 0.0 4.2 4 2 0 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Tagatose_6_P_K PF08013.11 ETO36546.1 - 0.11 11.1 0.0 35 2.9 0.0 3.7 4 0 0 4 4 4 0 Tagatose 6 phosphate kinase Peptidase_C69 PF03577.15 ETO36546.1 - 2 7.2 5.5 1.2e+02 1.4 0.0 4.8 7 0 0 7 7 7 0 Peptidase family C69 WD40 PF00400.32 ETO36547.1 - 7.6e-22 77.2 6.3 9.3e-08 32.6 0.6 3.5 3 0 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO36547.1 - 1e-06 27.8 1.9 0.0006 18.6 0.3 2.1 1 1 0 2 2 2 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36547.1 - 3.4e-05 23.3 1.8 0.00021 20.7 2.0 1.9 1 1 1 2 2 2 1 WD40-like domain ANAPC4_WD40 PF12894.7 ETO36547.1 - 0.00012 22.4 0.0 0.014 15.6 0.0 2.2 2 0 0 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Kelch_5 PF13854.6 ETO36548.1 - 0.004 17.1 0.3 0.035 14.1 0.1 2.4 2 0 0 2 2 2 1 Kelch motif m04gp34like PF12216.8 ETO36548.1 - 0.034 13.7 0.3 0.062 12.9 0.3 1.4 1 0 0 1 1 1 0 Immune evasion protein HCBP_related PF06594.11 ETO36548.1 - 0.058 13.3 0.1 0.17 11.9 0.1 1.8 1 0 0 1 1 1 0 Haemolysin-type calcium binding protein related domain WD40 PF00400.32 ETO36550.1 - 9.4e-31 105.4 14.2 1.8e-06 28.5 0.1 5.5 5 1 0 5 5 5 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36550.1 - 7.4e-10 39.0 0.3 0.004 17.4 0.0 3.6 3 1 0 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36550.1 - 9.8e-05 21.2 2.9 2.5 6.6 0.0 3.9 1 1 2 3 3 3 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36550.1 - 0.015 14.6 0.8 0.37 10.1 0.0 2.7 3 0 0 3 3 3 0 WD40-like domain DUF4964 PF16334.5 ETO36551.1 - 0.15 11.6 0.0 0.25 10.9 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4964) Tsi6 PF18660.1 ETO36553.1 - 0.019 15.0 0.8 0.21 11.7 0.1 2.1 2 0 0 2 2 2 0 Tsi6 DUF5494 PF17598.2 ETO36553.1 - 0.065 13.3 0.6 0.21 11.7 0.1 1.9 2 0 0 2 2 2 0 Family of unknown function (DUF5494) HTH_Tnp_Tc3_2 PF01498.18 ETO36554.1 - 2.5e-09 37.2 0.1 3.7e-09 36.7 0.1 1.2 1 0 0 1 1 1 1 Transposase GST_C PF00043.25 ETO36554.1 - 0.068 13.4 0.1 0.11 12.7 0.1 1.4 1 1 0 1 1 1 0 Glutathione S-transferase, C-terminal domain WD40 PF00400.32 ETO36556.1 - 3.8e-147 473.8 63.4 4.6e-11 43.1 0.3 15.4 15 0 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36556.1 - 5.4e-65 215.7 12.9 0.00031 21.0 0.0 14.9 2 1 13 15 15 15 14 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36556.1 - 1.3e-37 129.8 0.0 1e-06 28.3 0.0 8.5 3 3 2 8 8 8 7 WD40-like domain eIF2A PF08662.11 ETO36556.1 - 1.2e-21 77.5 0.0 0.0055 16.6 0.0 7.2 2 2 5 7 7 7 5 Eukaryotic translation initiation factor eIF2A PQQ_2 PF13360.6 ETO36556.1 - 2.9e-16 59.8 8.4 0.00041 20.0 0.2 5.6 2 2 1 4 4 4 4 PQQ-like domain Ge1_WD40 PF16529.5 ETO36556.1 - 4.9e-15 55.3 0.4 1 8.2 0.0 11.2 3 2 10 13 13 13 2 WD40 region of Ge1, enhancer of mRNA-decapping protein Cytochrom_D1 PF02239.16 ETO36556.1 - 3.6e-12 45.5 0.7 0.0018 16.9 0.0 5.8 3 3 3 6 6 6 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO36556.1 - 8.5e-08 31.9 16.1 8 6.5 0.0 10.7 11 0 0 11 11 11 1 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO36556.1 - 1.1e-06 28.2 0.0 3.5 7.7 0.0 7.6 9 0 0 9 9 8 1 PQQ enzyme repeat Gmad1 PF10647.9 ETO36556.1 - 5.3e-06 26.4 5.4 4.2 7.0 0.4 6.6 2 2 1 4 4 4 2 Lipoprotein LpqB beta-propeller domain Pentapeptide PF00805.22 ETO36556.1 - 2e-05 24.1 0.7 4e-05 23.2 0.0 1.9 2 0 0 2 2 1 1 Pentapeptide repeats (8 copies) PQQ_3 PF13570.6 ETO36556.1 - 2e-05 24.9 0.0 4.6 7.8 0.0 6.9 8 1 0 8 8 7 1 PQQ-like domain FCP1_C PF09309.10 ETO36556.1 - 0.00025 21.0 0.0 27 4.5 0.0 6.8 5 3 5 10 10 10 0 FCP1, C-terminal Pentapeptide_4 PF13599.6 ETO36556.1 - 0.0012 18.9 0.1 0.0038 17.3 0.1 1.9 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) LZ3wCH PF18517.1 ETO36556.1 - 0.016 15.3 0.4 0.04 14.0 0.4 1.6 1 0 0 1 1 1 0 Leucine zipper with capping helix domain Cuticle_1 PF08140.11 ETO36556.1 - 0.018 15.1 0.8 17 5.5 0.1 6.5 6 1 0 6 6 5 0 Crustacean cuticle protein repeat DUF4859 PF16151.5 ETO36556.1 - 0.04 13.8 0.6 3.8 7.4 0.1 3.7 3 0 0 3 3 3 0 Domain of unknown function (DUF4859) MMR_HSR1_C PF08438.10 ETO36556.1 - 0.11 13.1 0.0 6.9 7.3 0.0 3.0 2 0 0 2 2 2 0 GTPase of unknown function C-terminal DUF5570 PF17731.1 ETO36556.1 - 0.91 9.6 24.1 10 6.2 0.1 9.5 2 2 11 13 13 13 0 Family of unknown function (DUF5570) DUF5604 PF18300.1 ETO36556.1 - 1.3 9.1 10.1 6.3 6.8 0.0 5.5 5 3 2 7 7 7 0 Domain of unknown function (DUF5604) HEAT PF02985.22 ETO36558.1 - 3.4e-07 30.0 2.2 0.003 17.7 0.1 4.2 4 0 0 4 4 4 2 HEAT repeat HEAT_EZ PF13513.6 ETO36558.1 - 0.00024 21.5 0.0 0.89 10.1 0.0 4.0 4 0 0 4 4 4 1 HEAT-like repeat HEAT_2 PF13646.6 ETO36558.1 - 0.0024 18.2 0.1 0.056 13.8 0.0 2.7 3 1 0 3 3 3 1 HEAT repeats ENTH PF01417.20 ETO36558.1 - 0.0069 16.4 5.7 0.53 10.3 0.1 3.9 2 1 2 4 4 4 1 ENTH domain Vac14_Fab1_bd PF12755.7 ETO36558.1 - 0.015 15.9 0.6 0.054 14.1 0.2 2.2 2 1 0 2 2 2 0 Vacuolar 14 Fab1-binding region LXG PF04740.12 ETO36558.1 - 0.02 14.6 3.8 0.023 14.4 1.5 1.9 2 0 0 2 2 2 0 LXG domain of WXG superfamily ERAP1_C PF11838.8 ETO36558.1 - 0.031 13.8 0.0 0.057 12.9 0.0 1.4 2 0 0 2 2 2 0 ERAP1-like C-terminal domain DUF3486 PF11985.8 ETO36558.1 - 0.15 12.4 0.2 0.25 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3486) WD40 PF00400.32 ETO36560.1 - 8.4e-64 210.0 32.7 1.3e-10 41.6 0.5 7.4 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36560.1 - 6.9e-20 71.1 5.0 0.0031 17.8 0.0 6.9 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36560.1 - 3.3e-14 52.6 1.4 0.11 11.5 0.0 6.6 1 1 6 7 7 7 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36560.1 - 2.7e-11 43.4 1.8 0.037 13.4 0.0 4.2 3 1 1 4 4 4 3 WD40-like domain Str_synth PF03088.16 ETO36560.1 - 0.00026 21.1 0.1 4.9 7.3 0.0 4.6 3 2 2 5 5 5 1 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO36560.1 - 0.0023 16.5 1.5 1.1 7.7 0.2 3.1 1 1 3 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO36560.1 - 0.11 12.4 3.6 21 5.2 0.0 4.8 5 0 0 5 5 5 0 WD40-like Beta Propeller Repeat Gmad1 PF10647.9 ETO36560.1 - 0.13 12.0 0.2 0.89 9.3 0.1 2.3 2 1 0 2 2 2 0 Lipoprotein LpqB beta-propeller domain DUF5412 PF17428.2 ETO36561.1 - 0.063 13.1 0.1 0.063 13.1 0.1 2.4 2 1 0 2 2 2 0 Family of unknown function (DUF5412) Exo_endo_phos_2 PF14529.6 ETO36562.1 - 0.032 14.1 0.5 0.54 10.1 0.5 2.5 1 1 0 1 1 1 0 Endonuclease-reverse transcriptase EMP24_GP25L PF01105.24 ETO36563.1 - 4.2e-27 95.2 0.0 5.4e-27 94.9 0.0 1.1 1 0 0 1 1 1 1 emp24/gp25L/p24 family/GOLD DUF3888 PF13027.6 ETO36564.1 - 0.0098 16.3 0.2 0.018 15.5 0.2 1.5 1 1 0 1 1 1 1 Protein of unknown function (DUF3888) WD40 PF00400.32 ETO36565.1 - 2.6e-11 43.9 3.2 0.0018 19.0 0.0 3.8 3 2 0 3 3 3 3 WD domain, G-beta repeat CDP-OH_P_transf PF01066.21 ETO36566.1 - 1.4e-11 45.0 0.5 1.4e-11 45.0 0.5 2.4 3 0 0 3 3 3 1 CDP-alcohol phosphatidyltransferase RGS PF00615.19 ETO36567.1 - 0.00014 22.1 0.7 0.00049 20.4 0.7 2.0 1 1 0 1 1 1 1 Regulator of G protein signaling domain PAS_10 PF13596.6 ETO36567.1 - 0.007 16.9 0.1 0.015 15.9 0.1 1.5 1 0 0 1 1 1 1 PAS domain DUF4834 PF16118.5 ETO36567.1 - 0.044 14.7 0.5 0.044 14.7 0.5 2.2 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) CoA_binding_3 PF13727.6 ETO36567.1 - 0.083 12.9 0.1 0.083 12.9 0.1 2.3 2 0 0 2 2 2 0 CoA-binding domain DUF4820 PF16091.5 ETO36567.1 - 0.11 11.9 3.1 0.18 11.1 3.1 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) Antimicrobial19 PF08225.11 ETO36567.1 - 0.15 11.7 0.1 0.43 10.2 0.1 1.7 1 0 0 1 1 1 0 Pseudin antimicrobial peptide Kelch_1 PF01344.25 ETO36570.1 - 2.6e-08 33.3 3.1 9.7e-05 21.9 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO36570.1 - 2.1e-05 24.6 5.7 0.22 11.9 0.0 4.5 4 1 1 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO36570.1 - 0.0014 18.6 6.7 1.5 8.9 0.7 5.0 6 0 0 6 6 6 1 Kelch motif DUF2272 PF10030.9 ETO36570.1 - 0.0029 17.4 0.1 0.12 12.1 0.1 2.5 3 0 0 3 3 3 1 Uncharacterized protein conserved in bacteria (DUF2272) Kelch_2 PF07646.15 ETO36570.1 - 0.0086 16.0 2.6 0.52 10.4 0.4 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO36570.1 - 0.032 14.3 1.3 0.17 11.9 0.2 2.7 1 1 1 2 2 2 0 Galactose oxidase, central domain RhoGAP-FF1 PF16512.5 ETO36570.1 - 0.032 14.9 2.1 0.041 14.6 0.1 2.2 3 0 0 3 3 3 0 p190-A and -B Rho GAPs FF domain Beta_helix PF13229.6 ETO36572.1 - 0.054 13.4 0.0 0.067 13.0 0.0 1.1 1 0 0 1 1 1 0 Right handed beta helix region GRIM-19 PF06212.12 ETO36573.1 - 0.032 14.2 0.0 0.076 13.0 0.0 1.6 1 0 0 1 1 1 0 GRIM-19 protein FixQ PF05545.11 ETO36573.1 - 0.17 11.9 1.1 0.43 10.6 1.1 1.6 1 0 0 1 1 1 0 Cbb3-type cytochrome oxidase component FixQ TPR_12 PF13424.6 ETO36574.1 - 5e-44 148.5 4.0 8.5e-19 67.6 0.3 4.6 3 1 2 5 5 5 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36574.1 - 2.6e-25 87.5 0.0 1.4e-07 31.1 0.0 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36574.1 - 5.2e-25 86.2 21.6 6.9e-10 38.3 0.8 5.4 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36574.1 - 3e-24 83.2 19.6 5.9e-09 35.4 1.1 5.5 6 0 0 6 6 5 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36574.1 - 2e-20 71.2 12.5 1.1e-06 28.2 0.2 5.3 5 0 0 5 5 5 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36574.1 - 9.1e-20 69.2 7.5 3.8e-06 26.5 0.1 5.2 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36574.1 - 4.3e-11 42.7 0.2 0.037 14.7 0.0 4.9 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36574.1 - 3e-10 39.6 18.6 0.0051 16.5 1.6 6.8 5 3 3 8 8 8 3 TPR repeat SHNi-TPR PF10516.9 ETO36574.1 - 1.5e-09 37.2 8.6 0.0052 16.2 0.3 4.3 4 0 0 4 4 4 3 SHNi-TPR MIT PF04212.18 ETO36574.1 - 3e-09 36.8 7.8 0.011 15.8 0.9 4.6 4 0 0 4 4 4 4 MIT (microtubule interacting and transport) domain TPR_16 PF13432.6 ETO36574.1 - 3.1e-08 34.1 0.0 0.046 14.4 0.0 3.8 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36574.1 - 3.8e-08 33.2 8.3 0.0031 17.8 0.1 4.8 4 1 1 5 5 4 2 Tetratricopeptide repeat TPR_3 PF07720.12 ETO36574.1 - 9.9e-06 25.4 12.3 0.00084 19.3 0.3 4.0 4 0 0 4 4 4 2 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36574.1 - 0.00013 22.5 0.0 15 6.7 0.0 4.3 4 0 0 4 4 4 0 Tetratricopeptide repeat SPO22 PF08631.10 ETO36574.1 - 0.00028 20.5 1.3 0.091 12.2 0.1 2.4 2 0 0 2 2 2 2 Meiosis protein SPO22/ZIP4 like DUF2225 PF09986.9 ETO36574.1 - 0.00051 19.8 2.6 0.18 11.5 0.5 2.7 2 0 0 2 2 2 2 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 ETO36574.1 - 0.006 17.1 0.1 0.22 12.0 0.0 2.7 2 0 0 2 2 2 1 Tetratricopeptide repeat Bactofilin PF04519.13 ETO36574.1 - 0.0067 16.7 0.0 0.018 15.3 0.0 1.7 1 0 0 1 1 1 1 Polymer-forming cytoskeletal Cas_Cas02710 PF09670.10 ETO36574.1 - 0.012 14.4 0.2 0.036 12.9 0.0 1.8 2 0 0 2 2 2 0 CRISPR-associated protein (Cas_Cas02710) DUF5113 PF17140.4 ETO36574.1 - 0.014 15.2 8.3 0.51 10.1 0.9 3.3 1 1 2 3 3 3 0 Domain of unknown function (DUF5113) Sel1 PF08238.12 ETO36574.1 - 0.023 15.4 2.5 8.8 7.2 0.0 3.7 3 1 0 3 3 3 0 Sel1 repeat Pfk_N PF18468.1 ETO36574.1 - 0.024 15.0 1.0 0.22 11.9 0.3 2.6 2 0 0 2 2 2 0 Phosphofructokinase N-terminal domain yeast DUF627 PF04781.12 ETO36574.1 - 0.064 13.3 0.6 5.9 7.0 0.1 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF627) Ubiq-assoc PF09145.10 ETO36574.1 - 0.37 10.8 6.8 8.6 6.4 0.4 3.5 3 1 1 4 4 4 0 Ubiquitin-associated Ribosomal_L18A PF01775.17 ETO36575.1 - 4.4e-43 146.2 1.1 5.8e-43 145.8 0.4 1.5 2 0 0 2 2 2 1 Ribosomal proteins 50S-L18Ae/60S-L20/60S-L18A NAD_binding_6 PF08030.12 ETO36576.1 - 5e-14 52.7 0.0 1.9e-13 50.8 0.0 1.8 1 1 0 1 1 1 1 Ferric reductase NAD binding domain NAD_binding_1 PF00175.21 ETO36576.1 - 0.16 12.7 0.0 0.73 10.5 0.0 2.0 2 0 0 2 2 2 0 Oxidoreductase NAD-binding domain Ferric_reduct PF01794.19 ETO36577.1 - 1e-16 61.1 9.2 2.1e-16 60.2 9.2 1.5 1 0 0 1 1 1 1 Ferric reductase like transmembrane component FAD_binding_8 PF08022.12 ETO36577.1 - 2.6e-11 43.6 0.0 4.3e-11 42.9 0.0 1.4 1 0 0 1 1 1 1 FAD-binding domain FAD_binding_6 PF00970.24 ETO36577.1 - 0.022 15.1 0.0 0.032 14.6 0.0 1.3 1 0 0 1 1 1 0 Oxidoreductase FAD-binding domain SH3_9 PF14604.6 ETO36578.1 - 5.6e-14 51.7 0.7 1.1e-13 50.9 0.7 1.5 1 0 0 1 1 1 1 Variant SH3 domain SH3_2 PF07653.17 ETO36578.1 - 7.4e-14 51.2 0.3 2.1e-13 49.7 0.3 1.7 1 0 0 1 1 1 1 Variant SH3 domain SH3_1 PF00018.28 ETO36578.1 - 2.6e-12 46.1 0.7 4.9e-12 45.3 0.7 1.5 1 0 0 1 1 1 1 SH3 domain TMEM223 PF14640.6 ETO36578.1 - 0.04 14.1 0.5 0.04 14.1 0.5 1.7 2 0 0 2 2 2 0 Transmembrane protein 223 DUF3899 PF13038.6 ETO36578.1 - 0.048 14.2 0.8 0.048 14.2 0.8 2.6 2 1 0 2 2 2 0 Domain of unknown function (DUF3899) CBP_BcsG PF11658.8 ETO36578.1 - 0.048 12.1 0.1 0.067 11.6 0.1 1.2 1 0 0 1 1 1 0 Cellulose biosynthesis protein BcsG DUF4345 PF14248.6 ETO36578.1 - 0.052 13.5 2.5 0.051 13.5 1.2 1.7 1 1 0 1 1 1 0 Domain of unknown function (DUF4345) SH3_3 PF08239.11 ETO36578.1 - 0.46 10.8 2.1 0.79 10.0 1.1 1.9 2 0 0 2 2 2 0 Bacterial SH3 domain DUF4064 PF13273.6 ETO36578.1 - 1.9 8.8 8.3 26 5.2 4.3 3.4 1 1 2 3 3 3 0 Protein of unknown function (DUF4064) CBF PF03914.17 ETO36579.1 - 7.3e-14 52.1 15.9 6.4e-13 49.1 13.3 3.0 2 1 0 2 2 2 1 CBF/Mak21 family Presenilin PF01080.17 ETO36579.1 - 0.65 8.7 15.1 1.3 7.7 15.1 1.5 1 0 0 1 1 1 0 Presenilin Zip PF02535.22 ETO36579.1 - 3.3 6.8 10.3 8.2 5.5 10.3 1.7 1 0 0 1 1 1 0 ZIP Zinc transporter G-alpha PF00503.20 ETO36580.1 - 1.9e-76 257.5 14.3 4.7e-66 223.4 9.5 2.2 1 1 1 2 2 2 2 G-protein alpha subunit Arf PF00025.21 ETO36580.1 - 1.7e-11 43.9 0.3 7.6e-08 32.0 0.1 2.6 2 1 0 2 2 2 2 ADP-ribosylation factor family Roc PF08477.13 ETO36580.1 - 0.02 15.1 5.0 0.58 10.4 0.1 2.8 3 0 0 3 3 3 0 Ras of Complex, Roc, domain of DAPkinase DUF4293 PF14126.6 ETO36580.1 - 0.053 13.8 0.4 0.16 12.2 0.0 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4293) AAA_29 PF13555.6 ETO36580.1 - 0.082 12.7 0.0 0.2 11.4 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain ABC_tran PF00005.27 ETO36580.1 - 0.12 12.9 0.1 0.2 12.2 0.1 1.6 1 1 0 1 1 1 0 ABC transporter MMR_HSR1 PF01926.23 ETO36580.1 - 0.14 12.3 0.0 0.68 10.0 0.0 2.2 1 1 0 1 1 1 0 50S ribosome-binding GTPase Gtr1_RagA PF04670.12 ETO36580.1 - 0.96 8.7 11.9 0.074 12.4 0.4 2.8 3 0 0 3 3 3 0 Gtr1/RagA G protein conserved region GCK PF07802.11 ETO36581.1 - 0.0044 17.4 0.2 0.02 15.3 0.0 2.2 2 0 0 2 2 2 1 GCK domain Phage_int_SAM_1 PF02899.17 ETO36581.1 - 0.046 14.0 1.8 0.089 13.1 0.4 2.2 2 0 0 2 2 2 0 Phage integrase, N-terminal SAM-like domain Cep57_CLD_2 PF14197.6 ETO36581.1 - 0.05 13.7 0.8 0.05 13.7 0.8 3.6 4 1 0 4 4 4 0 Centrosome localisation domain of PPC89 RCC1 PF00415.18 ETO36582.1 - 4.2e-31 107.3 10.6 1.6e-12 47.8 0.1 5.7 5 1 0 5 5 5 4 Regulator of chromosome condensation (RCC1) repeat RCC1_2 PF13540.6 ETO36582.1 - 4.2e-16 58.3 20.2 7.3e-07 28.8 0.6 4.6 4 0 0 4 4 4 4 Regulator of chromosome condensation (RCC1) repeat Kelch_4 PF13418.6 ETO36582.1 - 0.085 12.9 0.3 0.74 9.9 0.0 2.4 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO36583.1 - 3.2e-07 30.1 2.7 0.021 14.8 0.3 5.0 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO36583.1 - 1.7e-06 27.5 3.4 0.0025 17.4 0.1 4.8 5 0 0 5 5 5 1 Kelch motif Kelch_6 PF13964.6 ETO36583.1 - 8.3e-06 25.9 1.6 8.3 6.9 0.0 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO36583.1 - 9.1e-05 22.4 1.1 0.68 10.0 0.0 3.7 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO36583.1 - 0.00016 21.6 1.0 2.7 8.1 0.2 4.3 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO36584.1 - 3.4e-08 33.2 2.3 0.0023 17.8 0.1 4.8 5 0 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO36584.1 - 7.5e-07 29.2 0.3 0.081 13.2 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO36584.1 - 2.6e-05 23.7 0.2 0.055 13.1 0.1 3.7 3 0 0 3 3 3 1 Kelch motif Kelch_4 PF13418.6 ETO36584.1 - 4.7e-05 23.3 1.5 0.0066 16.4 0.1 3.0 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_3 PF13415.6 ETO36584.1 - 0.063 13.6 0.1 0.3 11.4 0.0 2.2 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO36584.1 - 0.39 10.7 5.1 2.9 8.0 0.2 3.9 4 0 0 4 4 4 0 Kelch motif WD40 PF00400.32 ETO36585.1 - 1.1e-133 431.1 50.7 2.3e-09 37.7 0.1 16.2 15 1 0 15 15 15 15 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36585.1 - 8.1e-30 103.0 19.9 0.0094 16.2 0.1 12.9 2 2 11 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36585.1 - 1.2e-28 100.1 8.8 0.0041 16.1 0.0 13.2 1 1 11 13 13 13 8 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36585.1 - 6.9e-19 68.3 9.5 0.0031 16.9 0.0 7.8 3 3 4 8 8 8 5 WD40-like domain Nup160 PF11715.8 ETO36585.1 - 8.4e-16 57.7 21.4 0.59 8.7 0.0 13.2 3 2 11 14 14 14 7 Nucleoporin Nup120/160 Str_synth PF03088.16 ETO36585.1 - 1.5e-13 50.6 0.9 0.27 11.4 0.0 8.7 6 3 3 9 9 9 2 Strictosidine synthase Cytochrom_D1 PF02239.16 ETO36585.1 - 4.6e-07 28.7 2.5 0.13 10.8 0.0 5.7 2 1 3 6 6 6 2 Cytochrome D1 heme domain PD40 PF07676.12 ETO36585.1 - 1.8e-06 27.7 19.3 2 8.4 0.0 9.6 11 0 0 11 11 11 1 WD40-like Beta Propeller Repeat Pentapeptide PF00805.22 ETO36585.1 - 4.8e-06 26.1 0.3 1.1e-05 24.9 0.3 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) Nbas_N PF15492.6 ETO36585.1 - 1.3e-05 24.7 15.4 3.8 6.8 0.1 8.4 4 4 4 9 9 9 2 Neuroblastoma-amplified sequence, N terminal HARP PF07443.13 ETO36585.1 - 0.0035 16.9 0.3 26 4.6 0.0 6.0 9 0 0 9 9 9 0 HepA-related protein (HARP) Utp8 PF10395.9 ETO36585.1 - 0.015 13.8 2.9 1.1 7.6 0.0 3.6 3 1 0 4 4 4 0 Utp8 family Pentapeptide_4 PF13599.6 ETO36585.1 - 0.021 15.0 0.1 0.056 13.6 0.1 1.7 1 0 0 1 1 1 0 Pentapeptide repeats (9 copies) VID27 PF08553.10 ETO36585.1 - 0.04 13.0 0.1 5.7 5.9 0.0 3.7 4 0 0 4 4 4 0 VID27 C-terminal WD40-like domain zf-TRAF PF02176.18 ETO36586.1 - 7.3e-05 23.4 6.7 7.3e-05 23.4 6.7 2.3 2 0 0 2 2 2 1 TRAF-type zinc finger 4HB_MCP_1 PF12729.7 ETO36586.1 - 0.35 10.4 6.6 0.6 9.6 6.6 1.3 1 0 0 1 1 1 0 Four helix bundle sensory module for signal transduction Wbp11 PF09429.10 ETO36586.1 - 1.6 9.2 8.5 0.49 10.8 5.1 1.9 2 0 0 2 2 2 0 WW domain binding protein 11 ZapB PF06005.12 ETO36586.1 - 2.3 8.7 11.5 1.9 9.0 6.1 2.7 2 0 0 2 2 2 0 Cell division protein ZapB FapA PF03961.13 ETO36586.1 - 2.9 6.4 6.5 4.3 5.8 6.5 1.4 1 1 0 1 1 1 0 Flagellar Assembly Protein A PKcGMP_CC PF16808.5 ETO36586.1 - 6.5 6.7 9.8 0.99 9.3 3.4 2.7 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-TRAF PF02176.18 ETO36587.1 - 2.5e-06 28.1 6.0 4.9e-06 27.1 6.0 1.5 1 0 0 1 1 1 1 TRAF-type zinc finger DUF4435 PF14491.6 ETO36587.1 - 0.0018 18.2 2.6 0.0025 17.8 2.6 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF4435) YabA PF06156.13 ETO36587.1 - 0.0055 17.3 7.2 0.015 16.0 7.2 1.7 1 0 0 1 1 1 1 Initiation control protein YabA CC2-LZ PF16516.5 ETO36587.1 - 0.011 16.0 6.0 0.024 15.0 6.0 1.5 1 0 0 1 1 1 0 Leucine zipper of domain CC2 of NEMO, NF-kappa-B essential modulator PKcGMP_CC PF16808.5 ETO36587.1 - 0.045 13.6 9.8 0.048 13.5 5.5 2.4 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase DUF641 PF04859.12 ETO36587.1 - 0.28 11.5 6.9 0.64 10.4 6.9 1.7 1 1 0 1 1 1 0 Plant protein of unknown function (DUF641) FapA PF03961.13 ETO36587.1 - 0.47 9.0 5.2 0.62 8.6 5.2 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A TSC22 PF01166.18 ETO36587.1 - 4.5 7.7 11.0 2 8.8 3.7 2.8 2 1 1 3 3 3 0 TSC-22/dip/bun family RUN PF02759.19 ETO36588.1 - 0.00017 21.5 0.1 0.00047 20.1 0.1 1.8 1 0 0 1 1 1 1 RUN domain TPR_2 PF07719.17 ETO36588.1 - 2.7 8.3 6.4 13 6.2 0.1 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36588.1 - 3.1 7.8 9.1 11 6.0 0.2 3.8 4 0 0 4 4 4 0 Tetratricopeptide repeat Kelch_6 PF13964.6 ETO36589.1 - 3.5e-05 23.9 2.5 0.36 11.2 0.0 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO36589.1 - 0.00014 21.8 0.1 0.026 14.5 0.0 4.0 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO36589.1 - 0.00058 19.4 0.1 0.00058 19.4 0.1 3.2 4 1 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO36589.1 - 0.00065 19.9 1.7 0.02 15.2 0.0 3.7 4 0 0 4 4 4 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO36589.1 - 0.00095 19.1 0.7 17 5.5 0.0 4.4 4 0 0 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO36589.1 - 0.0036 17.2 7.4 0.015 15.3 0.1 4.3 4 1 0 4 4 4 1 Kelch motif Dicty_REP PF05086.12 ETO36589.1 - 0.0091 14.0 0.4 0.011 13.7 0.4 1.1 1 0 0 1 1 1 1 Dictyostelium (Slime Mold) REP protein PQQ_3 PF13570.6 ETO36589.1 - 0.13 12.8 0.1 29 5.3 0.0 2.9 3 0 0 3 3 3 0 PQQ-like domain SdrG_C_C PF10425.9 ETO36590.1 - 0.014 15.4 0.4 0.098 12.7 0.1 2.5 2 1 0 2 2 2 0 C-terminus of bacterial fibrinogen-binding adhesin mRNA_decap_C PF16741.5 ETO36590.1 - 0.058 12.7 0.6 0.16 11.3 0.6 1.8 1 0 0 1 1 1 0 mRNA-decapping enzyme C-terminus V_ATPase_I PF01496.19 ETO36592.1 - 0.9 7.4 19.1 1.1 7.1 19.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family 60KD_IMP PF02096.20 ETO36592.1 - 0.97 9.3 4.8 2.5 8.0 4.8 1.7 1 0 0 1 1 1 0 60Kd inner membrane protein WD40 PF00400.32 ETO36593.1 - 1.2e-127 412.1 34.4 1.3e-10 41.7 0.1 14.4 14 0 0 14 14 14 14 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36593.1 - 7.5e-44 148.0 4.7 0.00054 20.2 0.0 12.9 1 1 12 13 13 13 11 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36593.1 - 1.2e-31 109.9 3.1 0.059 12.3 0.0 12.3 1 1 10 12 12 12 10 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36593.1 - 7.9e-14 51.7 1.6 0.00031 20.2 0.0 5.8 5 1 1 6 6 6 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO36593.1 - 2e-13 49.7 3.3 0.0072 14.9 0.0 6.5 3 2 5 8 8 8 5 Cytochrome D1 heme domain PD40 PF07676.12 ETO36593.1 - 5.2e-12 45.4 12.4 6.1 6.9 0.0 11.1 11 0 0 11 11 11 1 WD40-like Beta Propeller Repeat Str_synth PF03088.16 ETO36593.1 - 3.8e-09 36.6 0.1 0.32 11.2 0.0 7.1 6 2 2 8 8 8 2 Strictosidine synthase Pentapeptide PF00805.22 ETO36593.1 - 1.4e-07 31.0 0.9 3.3e-07 29.8 0.9 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) DUF5570 PF17731.1 ETO36593.1 - 7.9e-06 26.0 9.0 15 5.7 0.0 9.2 4 3 5 10 10 10 0 Family of unknown function (DUF5570) VID27 PF08553.10 ETO36593.1 - 2.3e-05 23.7 0.2 0.65 9.0 0.0 5.2 5 1 1 6 6 6 1 VID27 C-terminal WD40-like domain Pentapeptide_4 PF13599.6 ETO36593.1 - 0.00029 20.9 0.1 0.0008 19.5 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Me-amine-dh_H PF06433.11 ETO36593.1 - 0.0029 16.5 0.1 2.1 7.1 0.0 4.2 3 2 1 4 4 4 2 Methylamine dehydrogenase heavy chain (MADH) Proteasome_A_N PF10584.9 ETO36593.1 - 0.0032 17.1 18.5 16 5.3 0.0 9.0 9 0 0 9 9 9 0 Proteasome subunit A N-terminal signature AcetylCoA_hyd_C PF13336.6 ETO36593.1 - 0.015 15.2 0.0 30 4.5 0.0 3.9 2 1 1 3 3 3 0 Acetyl-CoA hydrolase/transferase C-terminal domain Pentapeptide_3 PF13576.6 ETO36593.1 - 0.047 13.8 0.2 0.28 11.4 0.2 2.3 1 1 0 1 1 1 0 Pentapeptide repeats (9 copies) GCN5L1 PF06320.13 ETO36594.1 - 0.0026 17.9 1.2 0.0026 17.9 1.2 2.0 2 0 0 2 2 2 1 GCN5-like protein 1 (GCN5L1) Methyltransf_8 PF05148.15 ETO36596.1 - 7.2e-61 205.8 0.1 1.4e-60 204.9 0.1 1.5 1 0 0 1 1 1 1 Hypothetical methyltransferase Methyltransf_11 PF08241.12 ETO36596.1 - 9.3e-07 29.4 0.1 1e-05 26.1 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO36596.1 - 0.00068 20.3 0.1 0.0078 16.9 0.0 2.7 2 1 0 2 2 2 1 Methyltransferase domain Methyltransf_31 PF13847.6 ETO36596.1 - 0.083 12.7 6.8 0.27 11.0 0.1 3.0 2 2 0 2 2 2 0 Methyltransferase domain Methyltransf_32 PF13679.6 ETO36596.1 - 0.57 10.1 0.0 0.57 10.1 0.0 3.7 2 1 0 2 2 2 0 Methyltransferase domain Kelch_5 PF13854.6 ETO36598.1 - 0.0056 16.6 0.8 0.067 13.2 0.3 2.4 2 0 0 2 2 2 1 Kelch motif Kelch_1 PF01344.25 ETO36598.1 - 0.016 14.8 0.1 0.073 12.7 0.1 2.1 2 0 0 2 2 2 0 Kelch motif CobW_C PF07683.14 ETO36598.1 - 0.074 13.0 0.0 0.12 12.3 0.0 1.4 1 0 0 1 1 1 0 Cobalamin synthesis protein cobW C-terminal domain zf-C3HC4_3 PF13920.6 ETO36599.1 - 3.1e-14 52.5 9.7 5.6e-14 51.7 9.7 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) Prok-RING_4 PF14447.6 ETO36599.1 - 7.2e-08 32.2 10.4 1.1e-07 31.5 10.4 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 zf-C3HC4 PF00097.25 ETO36599.1 - 0.00021 21.1 13.3 0.00021 21.1 13.3 1.6 2 0 0 2 2 2 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO36599.1 - 0.00032 20.6 11.2 0.00062 19.7 11.2 1.5 1 0 0 1 1 1 1 zinc-RING finger domain DUF4202 PF13875.6 ETO36599.1 - 0.069 13.1 0.4 0.087 12.7 0.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4202) Rad50_zn_hook PF04423.14 ETO36599.1 - 0.1 12.5 0.8 0.1 12.5 0.8 2.7 3 0 0 3 3 3 0 Rad50 zinc hook motif zf-RVT PF13966.6 ETO36599.1 - 0.11 13.2 5.2 1.6 9.5 0.2 2.4 1 1 1 2 2 2 0 zinc-binding in reverse transcriptase PHF5 PF03660.14 ETO36599.1 - 0.3 11.3 0.1 0.3 11.3 0.1 2.7 1 1 2 3 3 3 0 PHF5-like protein zf-RING_UBOX PF13445.6 ETO36599.1 - 0.91 9.6 10.6 2.1 8.5 10.6 1.6 1 0 0 1 1 1 0 RING-type zinc-finger WD40 PF00400.32 ETO36600.1 - 5.2e-05 23.9 12.2 0.0011 19.7 0.9 3.8 2 1 1 3 3 3 2 WD domain, G-beta repeat WD40 PF00400.32 ETO36603.1 - 6.1e-13 49.0 10.9 9.9e-07 29.4 0.7 3.5 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36603.1 - 0.0013 19.0 0.1 0.0038 17.5 0.0 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36603.1 - 0.003 16.3 5.2 0.0091 14.7 5.2 1.6 1 1 0 1 1 1 1 Nucleoporin Nup120/160 Hph PF13694.6 ETO36603.1 - 0.0067 16.7 9.4 0.0067 16.7 9.4 1.4 2 0 0 2 2 2 1 Sec63/Sec62 complex-interacting family Lipoprotein_3 PF00938.17 ETO36603.1 - 0.055 13.6 2.0 0.099 12.8 1.4 1.7 1 1 0 1 1 1 0 Lipoprotein WD40 PF00400.32 ETO36604.1 - 3.5e-17 62.4 5.1 1.4e-06 28.9 0.8 3.6 3 1 0 3 3 3 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO36604.1 - 0.00053 18.8 0.1 0.35 9.5 0.1 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36604.1 - 0.002 18.4 0.3 0.95 9.8 0.1 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO36605.1 - 1.1e-09 38.7 3.1 9.4e-05 23.1 0.2 3.5 4 1 0 4 4 4 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO36605.1 - 0.0062 15.2 0.1 1 7.9 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Mss4 PF04421.13 ETO36606.1 - 0.045 13.9 0.3 0.066 13.4 0.3 1.4 1 1 0 1 1 1 0 Mss4 protein Asparaginase_2 PF01112.18 ETO36609.1 - 7.7e-22 77.7 0.0 1.7e-21 76.6 0.0 1.5 1 1 0 1 1 1 1 Asparaginase DUF3458_C PF17432.2 ETO36609.1 - 0.083 12.3 0.0 0.15 11.4 0.0 1.3 1 0 0 1 1 1 0 Domain of unknown function (DUF3458_C) ARM repeats DUF3671 PF12420.8 ETO36610.1 - 0.00086 19.4 3.9 0.0013 18.8 3.8 1.3 1 1 0 1 1 1 1 Protein of unknown function SARAF PF06682.12 ETO36610.1 - 0.0045 16.7 0.0 0.0045 16.7 0.0 1.1 1 0 0 1 1 1 1 SOCE-associated regulatory factor of calcium homoeostasis CHCH PF06747.13 ETO36610.1 - 0.013 15.7 10.7 0.19 11.9 0.1 3.8 4 0 0 4 4 4 0 CHCH domain Cmc1 PF08583.10 ETO36610.1 - 0.024 14.6 14.9 0.029 14.4 0.4 3.8 2 1 1 4 4 4 0 Cytochrome c oxidase biogenesis protein Cmc1 like CagY_M PF07337.11 ETO36610.1 - 0.029 14.0 1.6 0.029 14.0 1.6 2.8 4 0 0 4 4 4 0 DC-EC Repeat Cytomega_gL PF01801.16 ETO36610.1 - 0.037 13.4 0.0 0.063 12.7 0.0 1.4 2 0 0 2 2 2 0 Cytomegalovirus glycoprotein L DUF979 PF06166.12 ETO36610.1 - 0.048 12.8 0.0 0.055 12.6 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF979) DUF4519 PF15012.6 ETO36610.1 - 0.26 11.5 1.4 0.98 9.6 0.0 2.3 2 0 0 2 2 2 0 Domain of unknown function (DUF4519) WD40 PF00400.32 ETO36612.1 - 3.1e-11 43.6 21.9 7.3e-07 29.8 0.1 7.0 4 3 1 5 5 5 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36612.1 - 2.4e-05 24.6 0.3 0.0035 17.6 0.0 3.4 3 2 1 4 4 4 1 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36612.1 - 0.004 15.9 1.3 0.3 9.7 0.0 3.0 1 1 2 3 3 3 1 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO36612.1 - 0.016 15.3 0.1 0.068 13.2 0.0 2.1 2 0 0 2 2 2 0 Ciliary BBSome complex subunit 2, middle region WD40 PF00400.32 ETO36613.1 - 3.5e-17 62.5 2.6 3e-05 24.7 0.0 4.3 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36613.1 - 2.9e-05 24.3 0.3 0.15 12.3 0.1 3.2 2 1 1 3 3 3 2 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36613.1 - 4e-05 22.5 0.3 0.35 9.5 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 eIF2A PF08662.11 ETO36613.1 - 0.0035 17.3 0.4 0.12 12.2 0.1 2.3 1 1 2 3 3 3 1 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO36613.1 - 0.0036 16.7 2.3 0.011 15.0 0.7 2.0 1 1 1 2 2 2 1 WD40-like domain AIG1 PF04548.16 ETO36616.1 - 2.8e-06 26.8 0.0 2.8e-06 26.8 0.0 2.7 2 1 1 3 3 3 1 AIG1 family ApoO PF09769.9 ETO36616.1 - 2.1 8.3 6.0 0.41 10.6 1.2 2.3 2 0 0 2 2 2 0 Apolipoprotein O Ribonuc_red_lgC PF02867.15 ETO36618.1 - 2.7e-06 26.2 0.0 0.004 15.8 0.0 2.4 3 0 0 3 3 3 2 Ribonucleotide reductase, barrel domain DnaJ_C PF01556.18 ETO36621.1 - 6.7e-38 130.1 0.3 2.1e-37 128.5 0.3 1.8 1 1 0 1 1 1 1 DnaJ C terminal domain Ycf70 PF17382.2 ETO36621.1 - 0.74 10.2 4.8 33 5.0 0.9 3.3 3 0 0 3 3 3 0 Uncharacterized Ycf70-like Forkhead_N PF08430.12 ETO36621.1 - 1.6 9.3 19.9 2.5 8.7 19.9 1.2 1 0 0 1 1 1 0 Forkhead N-terminal region ADK PF00406.22 ETO36622.1 - 1.2e-07 31.9 0.3 1.4e-07 31.7 0.3 1.1 1 0 0 1 1 1 1 Adenylate kinase dNK PF01712.19 ETO36622.1 - 0.0088 15.9 0.1 0.01 15.7 0.1 1.1 1 0 0 1 1 1 1 Deoxynucleoside kinase AAA_17 PF13207.6 ETO36622.1 - 0.1 13.0 0.1 0.14 12.5 0.1 1.2 1 0 0 1 1 1 0 AAA domain ADK PF00406.22 ETO36623.1 - 1.1e-30 106.7 0.0 1.4e-30 106.4 0.0 1.1 1 0 0 1 1 1 1 Adenylate kinase AAA_17 PF13207.6 ETO36623.1 - 1.5e-22 80.5 0.1 2e-22 80.1 0.1 1.1 1 0 0 1 1 1 1 AAA domain AAA_18 PF13238.6 ETO36623.1 - 2e-06 28.4 0.1 2.9e-06 27.9 0.1 1.3 1 0 0 1 1 1 1 AAA domain Zeta_toxin PF06414.12 ETO36623.1 - 6e-06 25.7 0.0 1.5e-05 24.4 0.0 1.6 1 1 0 1 1 1 1 Zeta toxin AAA_33 PF13671.6 ETO36623.1 - 0.0069 16.6 0.0 0.0085 16.3 0.0 1.2 1 0 0 1 1 1 1 AAA domain AAA_19 PF13245.6 ETO36623.1 - 0.036 14.4 0.4 0.096 13.0 0.3 1.8 1 1 1 2 2 2 0 AAA domain NB-ARC PF00931.22 ETO36623.1 - 0.071 12.3 0.0 0.24 10.5 0.0 1.8 2 0 0 2 2 2 0 NB-ARC domain Viral_helicase1 PF01443.18 ETO36623.1 - 0.13 12.0 0.0 0.14 11.8 0.0 1.3 1 0 0 1 1 1 0 Viral (Superfamily 1) RNA helicase TPR_19 PF14559.6 ETO36624.1 - 1.3e-15 57.6 7.7 5.3e-06 26.9 0.1 5.0 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_17 PF13431.6 ETO36624.1 - 1.7e-15 56.2 2.4 0.00021 21.4 0.0 6.4 7 1 1 8 8 8 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36624.1 - 1.7e-12 46.8 8.1 1e-07 31.5 0.4 4.8 3 1 2 5 5 5 2 TPR repeat TPR_2 PF07719.17 ETO36624.1 - 3.6e-12 45.4 9.4 0.0028 17.7 0.0 6.7 8 0 0 8 8 8 3 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36624.1 - 4.3e-12 45.8 1.6 0.002 18.8 0.1 6.5 4 2 4 8 8 8 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36624.1 - 5.8e-12 44.8 5.9 0.0053 16.9 0.1 6.0 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36624.1 - 1.9e-10 40.1 13.2 0.00026 20.7 0.0 5.7 7 0 0 7 7 6 3 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36624.1 - 3.1e-09 37.3 0.2 3e-05 24.6 0.1 3.8 4 1 2 6 6 4 2 Tetratricopeptide repeat TPR_12 PF13424.6 ETO36624.1 - 7.5e-09 35.8 4.1 0.0029 17.9 0.2 4.1 3 1 1 4 4 4 2 Tetratricopeptide repeat ANAPC3 PF12895.7 ETO36624.1 - 2.3e-07 30.9 0.4 3.7e-06 27.1 0.1 2.6 1 1 1 2 2 2 1 Anaphase-promoting complex, cyclosome, subunit 3 TPR_20 PF14561.6 ETO36624.1 - 3e-06 27.5 5.7 0.035 14.4 0.1 3.7 3 1 1 4 4 4 2 Tetratricopeptide repeat TPR_9 PF13371.6 ETO36624.1 - 3.9e-05 23.7 0.1 0.0055 16.8 0.0 2.8 2 1 2 4 4 3 3 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36624.1 - 0.0013 19.2 1.7 4.5 8.1 0.0 4.4 5 0 0 5 5 4 1 Tetratricopeptide repeat Fis1_TPR_C PF14853.6 ETO36624.1 - 0.0036 17.4 0.2 7.8 6.7 0.1 4.2 3 1 1 4 4 4 1 Fis1 C-terminal tetratricopeptide repeat TPR_15 PF13429.6 ETO36624.1 - 0.011 15.0 0.9 2.5 7.2 0.2 3.0 1 1 2 3 3 3 0 Tetratricopeptide repeat DUF3209 PF11483.8 ETO36624.1 - 0.014 15.9 0.7 0.057 13.9 0.0 2.3 2 1 0 2 2 2 0 Protein of unknown function (DUF3209) MAS20 PF02064.15 ETO36624.1 - 0.063 13.4 0.1 1.7 8.8 0.0 2.5 2 0 0 2 2 2 0 MAS20 protein import receptor ChAPs PF09295.10 ETO36624.1 - 0.064 12.2 0.1 0.13 11.2 0.0 1.5 2 0 0 2 2 2 0 ChAPs (Chs5p-Arf1p-binding proteins) TPR_4 PF07721.14 ETO36624.1 - 0.066 13.9 0.0 1.1 10.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat Peptidase_M13_N PF05649.13 ETO36625.1 - 9.1e-08 32.2 0.0 1.3e-07 31.6 0.0 1.2 1 0 0 1 1 1 1 Peptidase family M13 WD40 PF00400.32 ETO36626.1 - 5.2e-41 137.9 7.9 3.3e-07 30.9 0.0 8.0 7 1 1 8 8 8 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36626.1 - 2e-17 63.2 1.5 0.028 14.7 0.0 6.4 1 1 4 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36626.1 - 1e-07 31.0 0.4 0.45 9.1 0.0 4.1 3 1 0 4 4 4 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO36626.1 - 5.3e-07 29.4 3.1 3.5 7.7 0.0 5.9 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Ge1_WD40 PF16529.5 ETO36626.1 - 1.2e-06 27.8 4.3 0.26 10.2 0.0 5.0 4 2 0 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein DPPIV_N PF00930.21 ETO36626.1 - 4e-06 25.8 0.1 0.0016 17.3 0.1 3.5 3 1 0 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region Kelch_6 PF13964.6 ETO36626.1 - 0.00032 20.9 4.9 0.016 15.5 0.1 4.2 3 1 1 4 4 4 1 Kelch motif Ribosomal_L35p PF01632.19 ETO36626.1 - 0.07 13.6 0.3 39 4.9 0.0 3.4 3 0 0 3 3 3 0 Ribosomal protein L35 DUF5570 PF17731.1 ETO36626.1 - 0.13 12.3 0.2 14 5.8 0.0 3.4 3 1 2 5 5 5 0 Family of unknown function (DUF5570) Kelch_1 PF01344.25 ETO36626.1 - 7.9 6.2 6.3 1.7 8.3 0.2 3.1 4 0 0 4 4 4 0 Kelch motif TPT PF03151.16 ETO36627.1 - 4.8e-11 42.5 13.4 2.1e-10 40.4 13.4 1.8 1 1 0 1 1 1 1 Triose-phosphate Transporter family Peptidase_M56 PF05569.11 ETO36627.1 - 0.076 12.2 3.6 0.075 12.2 2.5 1.6 1 1 1 2 2 2 0 BlaR1 peptidase M56 DUF2098 PF09871.9 ETO36627.1 - 0.15 12.4 0.4 17 5.8 0.4 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2098) TIP49 PF06068.13 ETO36628.1 - 4.4e-28 98.5 1.4 4.9e-28 98.3 1.4 1.2 1 0 0 1 1 1 1 TIP49 P-loop domain RuvB_N PF05496.12 ETO36628.1 - 8.2e-06 25.6 0.1 1e-05 25.3 0.1 1.3 1 0 0 1 1 1 1 Holliday junction DNA helicase RuvB P-loop domain AAA_16 PF13191.6 ETO36628.1 - 0.0054 17.1 0.1 0.0062 16.9 0.1 1.2 1 0 0 1 1 1 1 AAA ATPase domain Mg_chelatase PF01078.21 ETO36628.1 - 0.011 15.1 0.2 0.016 14.6 0.2 1.3 1 0 0 1 1 1 0 Magnesium chelatase, subunit ChlI AAA_25 PF13481.6 ETO36628.1 - 0.012 15.2 0.1 0.017 14.7 0.1 1.3 1 0 0 1 1 1 0 AAA domain AAA PF00004.29 ETO36628.1 - 0.021 15.2 0.2 0.033 14.6 0.2 1.4 1 0 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO36628.1 - 0.025 14.1 0.3 0.03 13.8 0.3 1.2 1 0 0 1 1 1 0 P-loop containing dynein motor region DUF2075 PF09848.9 ETO36628.1 - 0.049 12.9 0.1 0.38 9.9 0.2 2.0 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2075) Parvo_NS1 PF01057.17 ETO36628.1 - 0.054 12.6 0.3 0.11 11.6 0.1 1.4 1 1 0 1 1 1 0 Parvovirus non-structural protein NS1 RsgA_GTPase PF03193.16 ETO36628.1 - 0.058 13.3 0.5 0.08 12.8 0.5 1.2 1 0 0 1 1 1 0 RsgA GTPase AAA_5 PF07728.14 ETO36628.1 - 0.092 12.7 0.1 0.13 12.2 0.1 1.3 1 0 0 1 1 1 0 AAA domain (dynein-related subfamily) GvpD PF07088.11 ETO36628.1 - 0.11 11.1 0.1 0.16 10.6 0.1 1.2 1 0 0 1 1 1 0 GvpD gas vesicle protein DUF3915 PF13054.6 ETO36629.1 - 0.17 11.8 1.6 0.49 10.4 1.6 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF3915) FAM76 PF16046.5 ETO36629.1 - 1.2 8.5 10.5 1.7 7.9 10.5 1.2 1 0 0 1 1 1 0 FAM76 protein MCU PF04678.13 ETO36629.1 - 3.3 7.8 7.7 16 5.5 0.0 2.2 2 0 0 2 2 2 0 Mitochondrial calcium uniporter WD40 PF00400.32 ETO36630.1 - 8.1e-55 181.6 13.3 2.6e-10 40.7 0.6 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36630.1 - 1.9e-23 82.6 1.9 6.3e-05 23.2 0.0 5.4 2 2 3 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO36630.1 - 2.1e-12 47.3 0.3 1.6e-05 24.8 0.0 3.4 1 1 2 3 3 3 3 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO36630.1 - 8.4e-12 44.7 0.5 0.078 11.9 0.0 5.2 1 1 3 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36630.1 - 1.7e-10 40.7 0.2 0.00082 18.8 0.0 3.8 1 1 2 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO36630.1 - 1.2e-08 34.1 1.1 0.19 10.4 0.0 4.7 1 1 4 5 5 5 4 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO36630.1 - 2.6e-05 23.7 3.2 0.82 8.9 0.1 3.7 1 1 2 3 3 3 3 Neuroblastoma-amplified sequence, N terminal PD40 PF07676.12 ETO36630.1 - 0.00015 21.6 5.7 12 6.0 0.1 5.3 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat DUF5570 PF17731.1 ETO36630.1 - 0.00052 20.1 2.3 24 5.0 0.1 4.9 1 1 3 5 5 5 0 Family of unknown function (DUF5570) Cytochrom_D1 PF02239.16 ETO36630.1 - 0.00082 18.0 0.3 0.54 8.7 0.0 3.2 2 2 1 3 3 3 1 Cytochrome D1 heme domain PQQ PF01011.21 ETO36630.1 - 0.011 15.7 0.0 27 4.9 0.0 4.0 4 0 0 4 4 4 0 PQQ enzyme repeat DUF1513 PF07433.11 ETO36630.1 - 0.02 14.0 0.1 2.3 7.2 0.0 2.8 3 1 0 3 3 3 0 Protein of unknown function (DUF1513) Proteasome_A_N PF10584.9 ETO36630.1 - 0.031 14.0 4.4 27 4.6 0.0 4.8 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO36631.1 - 1.1e-29 102.1 8.9 2.4e-10 40.8 0.1 5.2 5 0 0 5 5 5 4 WD domain, G-beta repeat Ge1_WD40 PF16529.5 ETO36631.1 - 7.1e-12 44.9 0.1 0.0083 15.1 0.0 4.7 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein ANAPC4_WD40 PF12894.7 ETO36631.1 - 2e-11 44.0 1.0 0.0033 17.7 0.3 4.2 1 1 3 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO36631.1 - 1.6e-06 27.9 4.5 0.5 10.4 0.1 5.1 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat eIF2A PF08662.11 ETO36631.1 - 3.4e-06 27.1 0.1 0.0046 16.9 0.2 2.7 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO36631.1 - 6.9e-06 25.0 0.5 0.0023 16.7 0.1 2.2 1 1 1 2 2 2 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO36631.1 - 2.3e-05 23.1 0.2 0.00018 20.2 0.1 2.2 1 1 1 2 2 2 1 Cytochrome D1 heme domain WD40_like PF17005.5 ETO36631.1 - 3.5e-05 23.3 0.4 0.00013 21.5 0.3 1.8 1 1 0 1 1 1 1 WD40-like domain Str_synth PF03088.16 ETO36631.1 - 0.00082 19.4 0.1 0.18 11.9 0.0 3.6 2 1 1 4 4 4 1 Strictosidine synthase Nbas_N PF15492.6 ETO36631.1 - 0.033 13.5 0.5 11 5.2 0.0 3.2 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO36631.1 - 0.043 13.5 6.7 6.7 6.5 0.0 5.0 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature Coatomer_WDAD PF04053.14 ETO36631.1 - 0.061 12.4 0.6 0.13 11.3 0.4 1.8 2 1 0 2 2 2 0 Coatomer WD associated region DUF5570 PF17731.1 ETO36631.1 - 0.064 13.3 0.3 3.4 7.8 0.0 2.8 1 1 2 3 3 3 0 Family of unknown function (DUF5570) Mur_ligase PF01225.25 ETO36631.1 - 0.16 12.3 0.0 2 8.8 0.0 2.1 1 1 0 1 1 1 0 Mur ligase family, catalytic domain Lipoprotein_6 PF01441.19 ETO36632.1 - 0.042 13.9 3.7 0.087 12.8 3.7 1.6 1 1 0 1 1 1 0 Lipoprotein TSC22 PF01166.18 ETO36632.1 - 0.11 12.8 0.8 1.8 8.9 0.0 2.5 1 1 1 2 2 2 0 TSC-22/dip/bun family EIF_2_alpha PF07541.12 ETO36632.1 - 0.29 11.2 4.0 0.33 11.0 0.7 2.1 1 1 1 2 2 2 0 Eukaryotic translation initiation factor 2 alpha subunit DUF1043 PF06295.12 ETO36633.1 - 1.4 8.9 7.3 0.3 11.1 2.9 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1043) WD40 PF00400.32 ETO36636.1 - 7.2e-10 39.3 0.0 4e-08 33.8 0.0 2.2 2 0 0 2 2 2 1 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36636.1 - 0.0031 17.8 0.0 0.087 13.1 0.0 2.1 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain Crust_neuro_H PF03858.13 ETO36636.1 - 0.058 14.2 0.0 0.51 11.2 0.0 2.0 2 0 0 2 2 2 0 Crustacean neurohormone H EF-hand_1 PF00036.32 ETO36637.1 - 1.9e-05 23.9 0.9 0.0009 18.6 0.3 2.9 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO36637.1 - 0.00014 22.2 1.1 0.00014 22.2 1.1 2.1 2 0 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO36637.1 - 0.001 18.8 0.6 0.13 12.3 0.1 2.7 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ETO36637.1 - 0.0023 17.7 1.4 0.0049 16.7 1.4 1.6 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_5 PF13202.6 ETO36637.1 - 0.0087 15.5 0.5 0.028 13.9 0.5 1.8 1 0 0 1 1 1 1 EF hand Rotavirus_VP7 PF05868.11 ETO36637.1 - 0.024 14.0 0.3 0.036 13.4 0.3 1.2 1 0 0 1 1 1 0 Rotavirus major outer capsid protein VP7 DUF2481 PF10654.9 ETO36637.1 - 8 6.5 12.3 0.8 9.7 1.1 3.4 2 1 1 3 3 3 0 Protein of unknown function (DUF2481) TPR_MLP1_2 PF07926.12 ETO36638.1 - 0.17 12.0 31.4 6.6 6.8 26.4 3.1 2 1 1 3 3 3 0 TPR/MLP1/MLP2-like protein FAM25 PF15825.5 ETO36638.1 - 0.32 11.4 4.1 1.6 9.2 0.6 2.5 1 1 1 2 2 2 0 FAM25 family DUF948 PF06103.11 ETO36638.1 - 0.64 10.3 3.0 10 6.4 0.0 2.7 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) TSNAXIP1_N PF15739.5 ETO36638.1 - 2.3 8.6 22.3 0.91 9.9 13.5 2.8 1 1 2 3 3 3 0 Translin-associated factor X-interacting N-terminus Arc_PepC_II PF06847.11 ETO36638.1 - 4 8.0 9.2 7.2 7.2 4.1 2.5 1 1 0 2 2 2 0 Archaeal Peptidase A24 C-terminus Type II Tau95_N PF17682.1 ETO36638.1 - 4.9 7.4 8.2 1 9.5 3.2 2.1 2 0 0 2 2 2 0 Tau95 Triple barrel domain FapA PF03961.13 ETO36638.1 - 5.4 5.5 23.1 36 2.8 23.1 2.0 1 1 0 1 1 1 0 Flagellar Assembly Protein A WD40 PF00400.32 ETO36639.1 - 3.1e-26 91.1 6.0 1.1e-07 32.4 0.3 4.7 4 1 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36639.1 - 1.3e-09 38.2 0.1 0.0039 17.5 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36639.1 - 6.7e-05 21.7 0.4 0.37 9.4 0.1 2.9 1 1 2 3 3 3 2 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36639.1 - 0.00013 21.4 0.5 0.23 10.7 0.1 2.6 2 1 1 3 3 3 2 WD40-like domain eIF2A PF08662.11 ETO36639.1 - 0.043 13.7 0.0 2.9 7.7 0.0 2.5 2 1 0 2 2 2 0 Eukaryotic translation initiation factor eIF2A DUF4979 PF16351.5 ETO36639.1 - 0.073 13.3 0.7 0.72 10.1 0.4 2.1 1 1 1 2 2 2 0 Domain of unknown function (DUF4979) XK-related PF09815.9 ETO36641.1 - 0.00022 20.4 9.9 0.0004 19.5 6.2 2.4 1 1 0 2 2 2 1 XK-related protein ABC2_membrane_3 PF12698.7 ETO36641.1 - 0.098 11.7 6.7 0.13 11.4 6.7 1.1 1 0 0 1 1 1 0 ABC-2 family transporter protein Cupin_8 PF13621.6 ETO36643.1 - 3.8e-09 36.6 11.9 2.3e-08 34.0 11.9 2.0 1 1 0 1 1 1 1 Cupin-like domain Cupin_4 PF08007.12 ETO36643.1 - 0.0025 17.3 1.0 0.018 14.5 0.3 2.6 2 1 0 3 3 3 1 Cupin superfamily protein DUF2673 PF10880.8 ETO36643.1 - 0.004 17.2 0.1 0.013 15.6 0.1 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF2673) Cupin_2 PF07883.11 ETO36643.1 - 0.0062 16.2 0.1 2.9 7.7 0.0 2.5 2 0 0 2 2 2 2 Cupin domain Pkinase PF00069.25 ETO36644.1 - 1.3e-41 142.8 3.2 6.3e-33 114.3 0.0 3.9 4 0 0 4 4 4 3 Protein kinase domain Myosin_TH1 PF06017.13 ETO36644.1 - 8.7e-21 74.4 0.6 1.6e-20 73.6 0.6 1.4 1 0 0 1 1 1 1 Unconventional myosin tail, actin- and lipid-binding Pkinase_Tyr PF07714.17 ETO36644.1 - 2e-20 73.2 0.0 1.9e-15 56.9 0.0 2.3 2 0 0 2 2 2 2 Protein tyrosine kinase Pkinase_C PF00433.24 ETO36644.1 - 7.8e-06 26.5 3.3 2.3e-05 25.0 3.3 1.8 1 0 0 1 1 1 1 Protein kinase C terminal domain Pkinase_fungal PF17667.1 ETO36644.1 - 0.058 12.2 0.0 0.11 11.2 0.0 1.4 1 0 0 1 1 1 0 Fungal protein kinase XhlA PF10779.9 ETO36644.1 - 2.8 8.2 5.9 1.7 8.9 0.1 2.6 2 0 0 2 2 2 0 Haemolysin XhlA Phage_holin_7_1 PF16081.5 ETO36645.1 - 0.13 12.5 1.7 0.15 12.2 0.2 1.8 2 0 0 2 2 2 0 Mycobacterial 2 TMS Phage Holin (M2 Hol) Family Pro_dh PF01619.18 ETO36646.1 - 7.1e-85 285.1 0.2 8.8e-85 284.8 0.2 1.1 1 0 0 1 1 1 1 Proline dehydrogenase BclA_C PF18573.1 ETO36648.1 - 0.023 14.6 5.6 0.049 13.5 5.6 1.5 1 0 0 1 1 1 0 BclA C-terminal domain bZIP_1 PF00170.21 ETO36648.1 - 0.033 14.3 1.8 0.089 12.9 1.8 1.8 1 0 0 1 1 1 0 bZIP transcription factor HAP1_N PF04849.13 ETO36648.1 - 0.12 11.6 5.2 0.022 14.0 1.8 1.5 2 0 0 2 2 2 0 HAP1 N-terminal conserved region Rootletin PF15035.6 ETO36648.1 - 0.18 11.8 10.1 0.055 13.5 4.3 2.2 2 0 0 2 2 2 0 Ciliary rootlet component, centrosome cohesion bZIP_2 PF07716.15 ETO36648.1 - 0.37 10.9 2.4 0.85 9.7 2.4 1.6 1 0 0 1 1 1 0 Basic region leucine zipper RRP36 PF06102.12 ETO36648.1 - 0.92 9.5 8.1 1.8 8.5 1.5 2.3 2 0 0 2 2 2 0 rRNA biogenesis protein RRP36 ZapB PF06005.12 ETO36648.1 - 1.1 9.7 6.5 4.3 7.9 6.6 1.9 2 0 0 2 2 2 0 Cell division protein ZapB YabA PF06156.13 ETO36648.1 - 6.6 7.4 7.5 3.8 8.2 3.8 2.3 1 1 1 2 2 2 0 Initiation control protein YabA PTRF_SDPR PF15237.6 ETO36650.1 - 0.029 14.0 6.6 0.035 13.7 6.6 1.1 1 0 0 1 1 1 0 PTRF/SDPR family RR_TM4-6 PF06459.12 ETO36650.1 - 0.49 10.2 10.2 0.51 10.1 10.2 1.0 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 CDC45 PF02724.14 ETO36650.1 - 4.1 5.6 11.6 4.7 5.4 11.6 1.0 1 0 0 1 1 1 0 CDC45-like protein Perilipin PF03036.16 ETO36651.1 - 4.5 6.2 8.4 0.5 9.3 3.7 1.6 1 1 1 2 2 2 0 Perilipin family CBM26 PF16738.5 ETO36652.1 - 0.041 14.1 1.0 0.089 13.1 1.0 1.5 1 0 0 1 1 1 0 Starch-binding module 26 DUF966 PF06136.13 ETO36652.1 - 0.77 9.4 12.4 1.1 9.0 12.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF966) LBP_BPI_CETP PF01273.25 ETO36653.1 - 0.12 11.9 0.7 0.18 11.4 0.1 1.5 2 0 0 2 2 2 0 LBP / BPI / CETP family, N-terminal domain PHO4 PF01384.20 ETO36653.1 - 2.9 6.8 8.6 0.37 9.8 0.2 2.1 2 0 0 2 2 2 0 Phosphate transporter family MatE PF01554.18 ETO36653.1 - 4 7.1 15.5 3.3 7.3 2.9 2.9 2 1 0 2 2 2 0 MatE DnaJ_C PF01556.18 ETO36655.1 - 8.7e-15 55.1 0.0 9.9e-08 32.2 0.0 2.2 2 0 0 2 2 2 2 DnaJ C terminal domain DUF2781 PF10914.8 ETO36655.1 - 0.023 15.1 0.2 0.043 14.2 0.2 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF2781) EF-hand_6 PF13405.6 ETO36656.1 - 5.3e-13 47.8 2.0 0.00029 20.5 0.1 3.8 3 0 0 3 3 3 2 EF-hand domain EF-hand_7 PF13499.6 ETO36656.1 - 1.4e-11 44.7 1.5 8.4e-06 26.1 0.1 3.1 3 0 0 3 3 3 2 EF-hand domain pair EF-hand_1 PF00036.32 ETO36656.1 - 1.2e-10 40.2 5.5 0.00022 20.5 0.1 3.8 4 0 0 4 4 4 2 EF hand EF-hand_8 PF13833.6 ETO36656.1 - 6.1e-08 32.4 0.7 8.3e-05 22.4 0.1 2.5 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO36656.1 - 6.4e-07 28.6 4.4 0.0018 17.7 0.1 3.6 3 0 0 3 3 3 2 EF hand RexB PF15968.5 ETO36656.1 - 0.073 13.5 0.0 0.13 12.8 0.0 1.3 1 0 0 1 1 1 0 Membrane-anchored ion channel, Abi component WWE PF02825.20 ETO36657.1 - 1e-06 29.2 2.9 1.7e-06 28.6 0.1 2.7 3 0 0 3 3 3 1 WWE domain GWT1 PF06423.12 ETO36657.1 - 0.068 13.3 8.7 0.14 12.3 4.2 2.9 2 1 0 2 2 2 0 GWT1 PARP PF00644.20 ETO36658.1 - 2.6e-09 36.9 0.0 4.7e-09 36.1 0.0 1.5 1 0 0 1 1 1 1 Poly(ADP-ribose) polymerase catalytic domain Molybdopterin PF00384.22 ETO36658.1 - 0.059 12.3 0.0 0.061 12.3 0.0 1.1 1 0 0 1 1 1 0 Molybdopterin oxidoreductase Pkinase PF00069.25 ETO36659.1 - 1.3e-70 237.8 0.0 7.3e-70 235.3 0.0 1.9 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36659.1 - 1e-30 106.9 0.0 3.5e-30 105.1 0.0 1.7 1 1 0 1 1 1 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO36659.1 - 3e-05 23.5 0.0 5.8e-05 22.6 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO36659.1 - 0.00087 18.7 0.0 0.0018 17.7 0.0 1.5 1 0 0 1 1 1 1 Lipopolysaccharide kinase (Kdo/WaaP) family Pkinase_fungal PF17667.1 ETO36659.1 - 0.0028 16.5 0.0 0.0055 15.5 0.0 1.4 1 0 0 1 1 1 1 Fungal protein kinase DcrB PF08786.11 ETO36659.1 - 0.0049 17.0 0.2 0.01 15.9 0.2 1.5 1 0 0 1 1 1 1 DcrB APH PF01636.23 ETO36659.1 - 0.0051 16.8 0.3 0.051 13.5 0.0 2.4 2 1 1 3 3 3 1 Phosphotransferase enzyme family DcrB PF08786.11 ETO36660.1 - 0.059 13.5 8.1 0.12 12.5 8.1 1.5 1 0 0 1 1 1 0 DcrB XRN_N PF03159.18 ETO36661.1 - 1.1e-30 106.8 5.1 6.6e-26 91.2 3.7 3.1 1 1 1 2 2 2 2 XRN 5'-3' exonuclease N-terminus Choline_sulf_C PF12411.8 ETO36661.1 - 0.0075 16.1 0.0 0.02 14.7 0.0 1.8 1 1 0 1 1 1 1 Choline sulfatase enzyme C terminal DUF2800 PF10926.8 ETO36661.1 - 0.13 11.5 1.4 0.15 11.3 0.8 1.4 1 1 0 1 1 1 0 Protein of unknown function (DUF2800) DUF4615 PF15393.6 ETO36662.1 - 0.014 15.9 0.3 0.02 15.5 0.3 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4615) Mut7-C PF01927.16 ETO36663.1 - 3.9e-10 40.0 0.2 0.00068 19.8 0.0 2.9 3 0 0 3 3 3 2 Mut7-C RNAse domain Exo_endo_phos PF03372.23 ETO36663.1 - 0.058 12.9 1.0 0.36 10.3 1.0 2.2 1 1 0 1 1 1 0 Endonuclease/Exonuclease/phosphatase family PDE4_UCR PF18100.1 ETO36663.1 - 4.4 8.0 8.4 0.15 12.7 0.7 2.4 2 1 1 3 3 3 0 Phosphodiesterase 4 upstream conserved regions (UCR) Snf7 PF03357.21 ETO36664.1 - 5.7e-19 68.4 12.3 5.7e-19 68.4 12.3 2.7 2 1 1 3 3 3 1 Snf7 DUF4094 PF13334.6 ETO36664.1 - 0.0023 18.3 0.6 3.8 8.0 0.8 3.5 1 1 2 3 3 3 1 Domain of unknown function (DUF4094) UPF0184 PF03670.13 ETO36664.1 - 0.0082 16.5 4.0 1.1 9.7 0.0 3.3 4 0 0 4 4 4 1 Uncharacterised protein family (UPF0184) DivIC PF04977.15 ETO36664.1 - 0.016 14.9 13.3 0.44 10.4 0.7 3.9 4 1 0 4 4 3 0 Septum formation initiator DUF948 PF06103.11 ETO36664.1 - 0.046 14.0 1.7 1.8 8.9 0.1 3.1 3 0 0 3 3 3 0 Bacterial protein of unknown function (DUF948) FAM167 PF11652.8 ETO36664.1 - 0.061 13.8 0.6 1.1 9.7 0.1 2.7 2 0 0 2 2 2 0 FAM167 DUF1657 PF07870.11 ETO36664.1 - 0.1 12.5 2.3 2.8 7.9 0.3 2.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1657) Pox_E10 PF04805.12 ETO36664.1 - 0.16 11.9 0.8 11 6.0 0.1 2.7 2 0 0 2 2 2 0 E10-like protein conserved region Rota_NSP3 PF01665.16 ETO36664.1 - 0.29 10.2 5.2 1.1 8.3 5.0 1.8 1 1 1 2 2 2 0 Rotavirus non-structural protein NSP3 NapD PF03927.13 ETO36664.1 - 0.9 9.6 4.8 26 4.9 0.1 3.5 3 0 0 3 3 3 0 NapD protein Anti-adapt_IraP PF10796.9 ETO36664.1 - 1.2 9.8 6.8 13 6.5 0.1 3.4 3 0 0 3 3 3 0 Sigma-S stabilisation anti-adaptor protein CLZ PF16526.5 ETO36664.1 - 1.8 9.0 12.9 1.2 9.5 0.2 4.1 4 0 0 4 4 4 0 C-terminal leucine zipper domain of cyclic nucleotide-gated channels ATG16 PF08614.11 ETO36664.1 - 2.1 8.6 18.6 0.93 9.7 13.4 2.1 2 0 0 2 2 2 0 Autophagy protein 16 (ATG16) SHE3 PF17078.5 ETO36664.1 - 3.6 7.2 14.4 4 7.1 10.4 2.5 2 1 0 2 2 2 0 SWI5-dependent HO expression protein 3 DUF4407 PF14362.6 ETO36664.1 - 4 6.7 13.9 32 3.8 13.9 2.0 1 1 0 1 1 1 0 Domain of unknown function (DUF4407) FlaC_arch PF05377.11 ETO36664.1 - 6.6 7.2 11.1 11 6.6 0.0 4.1 4 0 0 4 4 4 0 Flagella accessory protein C (FlaC) DUF3546 PF12066.8 ETO36667.1 - 0.018 15.2 3.4 0.024 14.8 3.1 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF3546) EutC PF05985.11 ETO36667.1 - 0.039 13.3 0.7 1.2 8.4 0.1 2.1 1 1 1 2 2 2 0 Ethanolamine ammonia-lyase light chain (EutC) Cdh1_DBD_1 PF18196.1 ETO36668.1 - 0.021 15.1 4.6 0.023 15.0 4.0 1.3 1 1 0 1 1 1 0 Chromodomain helicase DNA-binding domain 1 Endonuc-BsobI PF09194.10 ETO36668.1 - 0.04 13.1 1.1 0.043 13.0 1.1 1.1 1 0 0 1 1 1 0 Restriction endonuclease BsobI CLIP_SPH_Scar PF18399.1 ETO36668.1 - 0.15 12.2 0.0 0.3 11.2 0.0 1.4 1 0 0 1 1 1 0 Clip-domain serine protease homolog Scarface zf-CCHC PF00098.23 ETO36669.1 - 0.026 14.6 4.4 0.044 13.9 4.4 1.4 1 0 0 1 1 1 0 Zinc knuckle zf-CCHC_5 PF14787.6 ETO36669.1 - 1.3 8.8 9.8 0.22 11.3 5.9 1.8 1 1 0 1 1 1 0 GAG-polyprotein viral zinc-finger DUF4890 PF16231.5 ETO36670.1 - 5 7.7 8.8 1.4 9.4 5.2 1.9 2 0 0 2 2 2 0 Domain of unknown function (DUF4890) Exo_endo_phos_2 PF14529.6 ETO36671.1 - 2.3e-09 37.1 0.2 4.3e-09 36.3 0.2 1.4 1 0 0 1 1 1 1 Endonuclease-reverse transcriptase HisG_C PF08029.11 ETO36672.1 - 0.1 12.8 0.0 0.2 11.8 0.0 1.5 1 0 0 1 1 1 0 HisG, C-terminal domain GUB_WAK_bind PF13947.6 ETO36672.1 - 1.2 9.9 3.8 2.1 9.1 0.2 2.8 2 1 1 3 3 3 0 Wall-associated receptor kinase galacturonan-binding WD40 PF00400.32 ETO36673.1 - 2.3e-120 389.0 45.7 1.4e-09 38.4 0.8 16.2 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36673.1 - 7.7e-34 115.9 12.4 0.0079 16.5 0.0 13.2 1 1 12 14 14 14 9 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36673.1 - 2.2e-21 76.2 3.1 0.67 8.8 0.0 12.5 3 2 11 14 14 14 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36673.1 - 6.2e-10 38.9 7.4 1.4 8.2 0.1 7.6 2 2 6 9 9 9 3 WD40-like domain Nup160 PF11715.8 ETO36673.1 - 1.4e-08 33.9 33.1 1.5 7.4 0.2 13.5 3 3 6 13 13 13 3 Nucleoporin Nup120/160 Pentapeptide PF00805.22 ETO36673.1 - 6.9e-07 28.8 5.0 1.9e-06 27.4 5.0 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) PD40 PF07676.12 ETO36673.1 - 1.7e-05 24.6 30.0 0.32 11.0 0.0 11.5 13 0 0 13 13 13 3 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO36673.1 - 0.00014 21.9 2.2 0.00041 20.4 2.2 1.8 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) Pentapeptide_4 PF13599.6 ETO36673.1 - 0.00087 19.4 0.4 0.0025 17.9 0.4 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PQQ_2 PF13360.6 ETO36673.1 - 0.0026 17.4 2.8 2.3 7.7 0.1 4.0 2 1 1 4 4 4 1 PQQ-like domain Mid2 PF04478.12 ETO36673.1 - 0.0032 17.3 3.7 12 5.7 0.2 6.0 5 2 1 6 6 6 0 Mid2 like cell wall stress sensor Gmad1 PF10647.9 ETO36673.1 - 0.0089 15.8 0.0 4.1 7.1 0.0 4.3 3 2 0 3 3 3 1 Lipoprotein LpqB beta-propeller domain Malectin_like PF12819.7 ETO36673.1 - 0.026 13.7 6.5 7.5 5.6 0.0 5.8 6 2 1 7 7 7 0 Malectin-like domain Plk4_PB1 PF18190.1 ETO36673.1 - 0.041 14.1 3.1 1.9e+02 2.3 0.0 6.2 5 2 1 6 6 6 0 Polo-like Kinase 4 Polo Box 1 Glyco_hydro_18 PF00704.28 ETO36673.1 - 0.044 13.5 0.0 0.12 12.0 0.0 1.7 1 0 0 1 1 1 0 Glycosyl hydrolases family 18 DUF5319 PF17252.2 ETO36673.1 - 0.16 12.2 0.0 16 5.7 0.0 3.6 2 1 1 3 3 3 0 Family of unknown function (DUF5319) Cytochrom_D1 PF02239.16 ETO36673.1 - 0.32 9.5 11.6 27 3.1 0.1 6.0 4 2 3 8 8 8 0 Cytochrome D1 heme domain UN_NPL4 PF11543.8 ETO36673.1 - 1.2 9.6 7.4 84 3.8 0.0 6.9 10 1 1 11 11 10 0 Nuclear pore localisation protein NPL4 NPV_P10 PF05531.12 ETO36676.1 - 0.00026 21.4 3.0 0.00026 21.4 3.0 2.4 2 1 0 2 2 2 1 Nucleopolyhedrovirus P10 protein PhaP_Bmeg PF09602.10 ETO36676.1 - 0.002 18.1 16.0 0.002 18.1 16.0 2.6 2 1 1 3 3 3 1 Polyhydroxyalkanoic acid inclusion protein (PhaP_Bmeg) HhH-GPD PF00730.25 ETO36676.1 - 0.086 13.3 1.9 0.52 10.8 1.9 2.5 1 1 0 1 1 1 0 HhH-GPD superfamily base excision DNA repair protein DUF4407 PF14362.6 ETO36676.1 - 0.14 11.4 7.6 0.28 10.5 7.6 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Noelin-1 PF12308.8 ETO36676.1 - 1.1 9.3 7.3 1.2 9.2 4.5 2.4 1 1 1 2 2 2 0 Neurogenesis glycoprotein BLOC1_2 PF10046.9 ETO36676.1 - 3.5 8.0 21.5 1.6 9.1 1.6 3.4 2 1 0 3 3 3 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 YojJ PF10372.9 ETO36676.1 - 4 7.6 13.8 6.1 7.0 7.3 3.3 2 1 1 3 3 3 0 Bacterial membrane-spanning protein N-terminus Fib_alpha PF08702.10 ETO36676.1 - 6.9 6.8 23.3 4 7.6 16.9 2.3 2 0 0 2 2 2 0 Fibrinogen alpha/beta chain family Tweety PF04906.13 ETO36676.1 - 7.5 5.1 7.9 4.4 5.9 2.8 1.9 1 1 1 2 2 2 0 Tweety DUF349 PF03993.12 ETO36676.1 - 8.5 6.8 20.7 4.1e+02 1.4 20.7 2.9 1 1 0 1 1 1 0 Domain of Unknown Function (DUF349) BLOC1_2 PF10046.9 ETO36677.1 - 0.00013 22.2 0.3 0.00018 21.8 0.3 1.2 1 0 0 1 1 1 1 Biogenesis of lysosome-related organelles complex-1 subunit 2 DivIC PF04977.15 ETO36677.1 - 0.0076 16.0 2.7 0.01 15.6 2.5 1.5 1 1 0 1 1 1 1 Septum formation initiator Mod_r PF07200.13 ETO36677.1 - 0.017 15.2 1.8 0.019 15.1 1.8 1.2 1 0 0 1 1 1 0 Modifier of rudimentary (Mod(r)) protein DUF4988 PF16378.5 ETO36677.1 - 0.025 14.3 0.5 0.032 13.9 0.5 1.2 1 0 0 1 1 1 0 Domain of unknown function bZIP_2 PF07716.15 ETO36677.1 - 0.038 14.1 0.8 0.084 13.0 0.8 1.5 1 0 0 1 1 1 0 Basic region leucine zipper FAM76 PF16046.5 ETO36677.1 - 0.04 13.3 1.3 0.036 13.4 1.3 1.1 1 0 0 1 1 1 0 FAM76 protein ABC_membrane_2 PF06472.15 ETO36679.1 - 1.2e-06 28.1 0.1 1.7e-06 27.7 0.1 1.2 1 0 0 1 1 1 1 ABC transporter transmembrane region 2 BSP_II PF05432.11 ETO36679.1 - 0.00095 19.0 26.8 0.0013 18.5 26.8 1.1 1 0 0 1 1 1 1 Bone sialoprotein II (BSP-II) SID-1_RNA_chan PF13965.6 ETO36679.1 - 0.12 10.8 2.3 0.16 10.4 2.3 1.3 1 0 0 1 1 1 0 dsRNA-gated channel SID-1 Hid1 PF12722.7 ETO36679.1 - 0.17 10.0 15.2 0.19 9.8 15.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein BUD22 PF09073.10 ETO36679.1 - 0.7 9.2 29.1 0.45 9.8 27.6 1.4 2 0 0 2 2 2 0 BUD22 SDA1 PF05285.12 ETO36679.1 - 3.3 7.1 33.5 4 6.8 33.5 1.1 1 0 0 1 1 1 0 SDA1 CDC45 PF02724.14 ETO36679.1 - 3.3 5.9 26.0 4.8 5.4 26.0 1.3 1 0 0 1 1 1 0 CDC45-like protein ABC_tran PF00005.27 ETO36680.1 - 1.8e-18 67.4 0.0 3.7e-18 66.4 0.0 1.5 1 1 0 1 1 1 1 ABC transporter AAA_21 PF13304.6 ETO36680.1 - 3.1e-07 30.5 0.2 1.9e-05 24.7 0.1 2.2 1 1 0 2 2 2 1 AAA domain, putative AbiEii toxin, Type IV TA system AAA_29 PF13555.6 ETO36680.1 - 0.00029 20.5 0.0 0.00059 19.5 0.0 1.4 1 0 0 1 1 1 1 P-loop containing region of AAA domain AAA_23 PF13476.6 ETO36680.1 - 0.00052 20.6 0.2 0.001 19.6 0.2 1.4 1 0 0 1 1 1 1 AAA domain SMC_N PF02463.19 ETO36680.1 - 0.002 17.6 0.1 0.0059 16.1 0.1 1.7 2 0 0 2 2 2 1 RecF/RecN/SMC N terminal domain AAA_15 PF13175.6 ETO36680.1 - 0.0061 16.3 0.0 0.0091 15.7 0.0 1.3 1 0 0 1 1 1 1 AAA ATPase domain FtsK_SpoIIIE PF01580.18 ETO36680.1 - 0.019 14.3 0.0 0.029 13.7 0.0 1.3 1 0 0 1 1 1 0 FtsK/SpoIIIE family AAA_30 PF13604.6 ETO36680.1 - 0.044 13.5 0.0 0.073 12.8 0.0 1.2 1 0 0 1 1 1 0 AAA domain AAA_16 PF13191.6 ETO36680.1 - 0.15 12.4 0.0 0.25 11.7 0.0 1.3 1 0 0 1 1 1 0 AAA ATPase domain MMR_HSR1 PF01926.23 ETO36680.1 - 0.15 12.1 0.1 0.33 11.0 0.1 1.5 1 0 0 1 1 1 0 50S ribosome-binding GTPase DUF815 PF05673.13 ETO36680.1 - 0.16 11.1 0.1 0.27 10.3 0.1 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF815) PHD_2 PF13831.6 ETO36682.1 - 6.5e-05 22.4 0.3 6.5e-05 22.4 0.3 3.9 4 0 0 4 4 4 2 PHD-finger zf-HC5HC2H PF13771.6 ETO36682.1 - 0.00057 20.1 0.6 0.00057 20.1 0.6 5.7 4 3 1 6 6 6 2 PHD-like zinc-binding domain SR-25 PF10500.9 ETO36682.1 - 0.27 10.8 24.7 0.42 10.2 13.2 2.3 2 0 0 2 2 2 0 Nuclear RNA-splicing-associated protein C1_1 PF00130.22 ETO36682.1 - 0.9 9.5 21.9 0.056 13.3 2.1 5.2 5 0 0 5 5 5 0 Phorbol esters/diacylglycerol binding domain (C1 domain) PHD PF00628.29 ETO36682.1 - 1.2 9.1 24.0 0.7 9.8 5.7 5.1 5 1 0 5 5 5 0 PHD-finger zf-HC5HC2H_2 PF13832.6 ETO36682.1 - 1.3 9.2 28.9 0.24 11.6 0.8 5.8 3 2 1 5 5 5 0 PHD-zinc-finger like domain Exo_endo_phos_2 PF14529.6 ETO36683.1 - 3.4e-13 49.5 0.3 8e-13 48.3 0.1 1.7 2 0 0 2 2 2 1 Endonuclease-reverse transcriptase BAF PF02961.14 ETO36684.1 - 0.06 13.8 0.2 0.1 13.0 0.1 1.4 1 1 0 1 1 1 0 Barrier to autointegration factor RVT_1 PF00078.27 ETO36685.1 - 8.2e-09 35.3 0.4 8.1e-08 32.0 0.1 2.1 1 1 1 2 2 2 1 Reverse transcriptase (RNA-dependent DNA polymerase) Cohesin_load PF10345.9 ETO36685.1 - 0.0016 17.0 2.3 0.0022 16.5 2.3 1.2 1 0 0 1 1 1 1 Cohesin loading factor Herpes_TK_C PF08465.10 ETO36685.1 - 0.16 11.7 0.1 0.39 10.5 0.1 1.7 1 0 0 1 1 1 0 Thymidine kinase from Herpesvirus C-terminal WD40 PF00400.32 ETO36687.1 - 5.6e-18 65.0 13.1 2.1e-06 28.3 0.1 4.1 4 0 0 4 4 4 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO36687.1 - 3.5e-08 32.6 0.6 0.00079 18.2 0.0 3.0 1 1 2 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36687.1 - 3.5e-07 30.4 0.2 0.1 12.9 0.0 3.1 1 1 2 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain WD40 PF00400.32 ETO36688.1 - 2.8e-61 202.0 8.4 5.1e-11 43.0 0.0 7.2 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36688.1 - 5.7e-27 93.9 1.2 0.0054 17.0 0.0 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36688.1 - 1.3e-13 50.7 0.0 0.0084 15.1 0.0 5.9 1 1 5 6 6 6 3 WD40 region of Ge1, enhancer of mRNA-decapping protein PD40 PF07676.12 ETO36688.1 - 9.6e-11 41.3 0.2 2 8.5 0.0 7.1 7 0 0 7 7 7 2 WD40-like Beta Propeller Repeat WD40_like PF17005.5 ETO36688.1 - 1.5e-08 34.3 0.7 0.0027 17.1 0.0 3.8 3 2 0 3 3 3 2 WD40-like domain DUF5570 PF17731.1 ETO36688.1 - 1.1e-07 31.9 0.0 0.3 11.2 0.0 4.8 1 1 3 5 5 5 2 Family of unknown function (DUF5570) Nup160 PF11715.8 ETO36688.1 - 1.8e-05 23.6 1.0 1.8 7.1 0.0 4.6 2 2 1 3 3 3 2 Nucleoporin Nup120/160 HPS6 PF15702.5 ETO36688.1 - 0.00073 17.7 0.0 2.1 6.3 0.0 3.6 1 1 2 4 4 4 2 Hermansky-Pudlak syndrome 6 protein Proteasome_A_N PF10584.9 ETO36688.1 - 0.00082 19.0 0.7 52 3.7 0.0 5.2 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature DUF3748 PF12566.8 ETO36688.1 - 0.00091 19.2 0.1 53 3.8 0.0 4.9 1 1 4 5 5 5 0 Protein of unknown function (DUF3748) Coatomer_WDAD PF04053.14 ETO36688.1 - 0.0017 17.5 0.1 0.0097 15.0 0.0 1.9 1 1 1 2 2 2 1 Coatomer WD associated region Cytochrom_D1 PF02239.16 ETO36688.1 - 0.0022 16.6 0.1 0.44 9.0 0.0 3.1 1 1 3 4 4 4 2 Cytochrome D1 heme domain DPPIV_N PF00930.21 ETO36688.1 - 0.0031 16.3 0.0 7.2 5.3 0.0 3.9 2 2 2 4 4 4 1 Dipeptidyl peptidase IV (DPP IV) N-terminal region DUF4999 PF16390.5 ETO36688.1 - 0.0079 16.4 0.6 63 3.9 0.0 4.3 4 0 0 4 4 4 0 Domain of unknown function Utp8 PF10395.9 ETO36688.1 - 0.18 10.3 0.6 11 4.4 0.0 2.4 2 1 0 2 2 2 0 Utp8 family DUF2387 PF09526.10 ETO36688.1 - 0.3 11.3 1.5 14 5.9 0.0 3.5 3 1 1 4 4 4 0 Probable metal-binding protein (DUF2387) PKcGMP_CC PF16808.5 ETO36689.1 - 0.074 12.9 2.1 0.26 11.2 0.9 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of cGMP-dependent protein kinase zf-RING-like PF08746.11 ETO36689.1 - 0.16 12.3 2.5 0.73 10.2 2.6 2.3 1 1 0 1 1 1 0 RING-like domain Rootletin PF15035.6 ETO36689.1 - 0.7 9.9 11.5 1.4 8.9 11.5 1.5 1 0 0 1 1 1 0 Ciliary rootlet component, centrosome cohesion DUF16 PF01519.16 ETO36689.1 - 1.4 9.5 11.1 20 5.7 11.1 2.5 1 1 0 1 1 1 0 Protein of unknown function DUF16 WD40 PF00400.32 ETO36690.1 - 2.3e-61 202.3 14.7 6.3e-11 42.7 0.0 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36690.1 - 9.1e-24 83.6 1.5 0.011 16.0 0.1 7.0 1 1 6 7 7 7 6 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36690.1 - 1e-16 60.9 0.8 0.029 13.3 0.0 6.7 1 1 6 7 7 7 6 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO36690.1 - 5.2e-16 59.1 0.0 0.0005 20.0 0.0 3.8 1 1 3 4 4 4 4 Eukaryotic translation initiation factor eIF2A Nup160 PF11715.8 ETO36690.1 - 6.4e-08 31.7 8.0 0.039 12.6 0.2 6.2 1 1 4 5 5 5 2 Nucleoporin Nup120/160 Cytochrom_D1 PF02239.16 ETO36690.1 - 1.4e-07 30.4 1.2 0.1 11.1 0.0 3.9 2 2 2 4 4 4 4 Cytochrome D1 heme domain WD40_like PF17005.5 ETO36690.1 - 5.9e-07 29.1 0.5 0.11 11.8 0.1 3.9 1 1 2 4 4 4 2 WD40-like domain PD40 PF07676.12 ETO36690.1 - 4.9e-05 23.2 6.6 5.5 7.0 0.0 5.4 6 0 0 6 6 6 2 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO36690.1 - 6.9e-05 21.8 7.3 1 8.0 1.1 4.1 1 1 2 4 4 4 3 Nup133 N terminal like Nbas_N PF15492.6 ETO36690.1 - 0.0002 20.8 2.2 1.3 8.3 0.0 4.1 2 2 2 4 4 4 2 Neuroblastoma-amplified sequence, N terminal Utp8 PF10395.9 ETO36690.1 - 0.00098 17.8 0.3 0.25 9.8 0.0 2.1 2 0 0 2 2 2 2 Utp8 family Frtz PF11768.8 ETO36690.1 - 0.0017 16.7 0.1 0.3 9.3 0.0 2.8 2 1 2 4 4 4 1 WD repeat-containing and planar cell polarity effector protein Fritz Coatomer_WDAD PF04053.14 ETO36690.1 - 0.0081 15.3 3.0 3.1 6.7 0.1 2.9 2 1 1 3 3 3 2 Coatomer WD associated region DUF1854 PF08909.11 ETO36690.1 - 0.053 13.3 0.1 9.2 6.1 0.0 2.7 1 1 2 3 3 3 0 Domain of unknown function (DUF1854) nos_propeller PF18764.1 ETO36690.1 - 0.095 12.6 0.0 63 3.6 0.0 3.6 3 1 1 4 4 4 0 Nitrous oxide reductase propeller repeat POLO_box PF00659.18 ETO36690.1 - 0.095 12.9 0.0 0.78 10.0 0.0 2.4 1 1 1 2 2 2 0 POLO box duplicated region DUF1387 PF07139.11 ETO36691.1 - 6.8 6.3 21.7 8 6.1 21.7 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1387) UQ_con PF00179.26 ETO36693.1 - 6.4e-14 51.8 0.9 1.7e-09 37.4 0.4 2.2 2 0 0 2 2 2 2 Ubiquitin-conjugating enzyme Prok-E2_B PF14461.6 ETO36693.1 - 0.0017 18.1 0.0 0.0026 17.4 0.0 1.4 1 0 0 1 1 1 1 Prokaryotic E2 family B DUF4688 PF15752.5 ETO36693.1 - 0.026 13.8 0.2 0.036 13.3 0.2 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4688) RWD PF05773.22 ETO36693.1 - 0.14 12.5 0.1 0.22 11.8 0.1 1.4 1 0 0 1 1 1 0 RWD domain ABC_tran PF00005.27 ETO36694.1 - 2.1e-28 99.5 0.3 4e-28 98.6 0.0 1.6 2 0 0 2 2 2 1 ABC transporter SMC_N PF02463.19 ETO36694.1 - 0.00048 19.6 1.2 0.15 11.5 0.0 2.2 1 1 1 2 2 2 2 RecF/RecN/SMC N terminal domain MMR_HSR1 PF01926.23 ETO36694.1 - 0.013 15.5 0.0 0.048 13.7 0.0 2.0 1 0 0 1 1 1 0 50S ribosome-binding GTPase AAA_29 PF13555.6 ETO36694.1 - 0.014 15.1 0.0 0.034 13.9 0.0 1.6 1 0 0 1 1 1 0 P-loop containing region of AAA domain AAA_22 PF13401.6 ETO36694.1 - 0.016 15.4 0.1 0.16 12.3 0.0 2.5 2 1 0 2 2 2 0 AAA domain DUF87 PF01935.17 ETO36694.1 - 0.017 15.2 0.7 0.051 13.7 0.7 2.0 1 1 0 1 1 1 0 Helicase HerA, central domain AAA_21 PF13304.6 ETO36694.1 - 0.069 12.9 0.4 0.68 9.7 0.1 2.1 1 1 1 2 2 2 0 AAA domain, putative AbiEii toxin, Type IV TA system Bac_rhamnosid6H PF17389.2 ETO36694.1 - 0.082 12.1 0.0 0.13 11.5 0.0 1.3 1 0 0 1 1 1 0 Bacterial alpha-L-rhamnosidase 6 hairpin glycosidase domain Nitroreductase PF00881.24 ETO36695.1 - 0.17 12.0 0.0 0.29 11.2 0.0 1.3 1 0 0 1 1 1 0 Nitroreductase family D123 PF07065.14 ETO36696.1 - 2e-05 23.9 26.4 0.0044 16.2 26.4 4.1 1 1 0 1 1 1 1 D123 R2K_3 PF14243.6 ETO36696.1 - 0.00029 20.9 0.2 0.00046 20.3 0.2 1.3 1 0 0 1 1 1 1 ATP-grasp domain, R2K clade family 3 DDHD PF02862.17 ETO36696.1 - 0.0039 17.4 0.9 0.022 15.0 0.7 1.9 2 0 0 2 2 2 1 DDHD domain Secretin_N_2 PF07655.13 ETO36696.1 - 1 9.9 18.0 5.1 7.7 10.3 2.5 2 0 0 2 2 2 0 Secretin N-terminal domain NST1 PF13945.6 ETO36696.1 - 1.1 9.3 15.5 1.5 8.9 9.1 2.2 2 0 0 2 2 2 0 Salt tolerance down-regulator ELFV_dehydrog_N PF02812.18 ETO36697.1 - 8.6e-24 83.9 0.0 1.4e-23 83.2 0.0 1.3 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain ELFV_dehydrog PF00208.21 ETO36698.1 - 1.5e-42 146.0 0.0 1.8e-39 135.9 0.0 2.1 2 0 0 2 2 2 2 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase ELFV_dehydrog_N PF02812.18 ETO36698.1 - 3.5e-14 52.8 0.0 6.2e-14 52.0 0.0 1.4 1 0 0 1 1 1 1 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain Sulfotransfer_1 PF00685.27 ETO36699.1 - 1.1e-06 28.4 3.1 0.00035 20.2 3.1 2.8 1 1 0 1 1 1 1 Sulfotransferase domain AAA_23 PF13476.6 ETO36700.1 - 0.78 10.2 9.6 1 9.9 9.6 1.1 1 0 0 1 1 1 0 AAA domain GEN1_C PF18380.1 ETO36701.1 - 0.073 14.0 0.7 0.073 14.0 0.7 2.3 2 1 0 2 2 2 0 Holliday junction resolvase Gen1 C-terminal domain LANC_like PF05147.13 ETO36702.1 - 7.5e-50 169.5 1.7 1.7e-47 161.7 0.8 2.1 2 0 0 2 2 2 2 Lanthionine synthetase C-like protein SUD-M PF11633.8 ETO36702.1 - 0.11 12.2 0.0 0.2 11.4 0.0 1.4 1 0 0 1 1 1 0 Single-stranded poly(A) binding domain RMI1_N PF08585.12 ETO36703.1 - 1.1e-07 31.8 6.7 6.6e-07 29.3 0.4 2.9 1 1 1 2 2 2 1 RecQ mediated genome instability protein WD40 PF00400.32 ETO36704.1 - 1.4e-40 136.5 28.8 1.5e-06 28.8 3.2 7.9 7 1 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36704.1 - 1.2e-13 51.2 1.5 0.004 17.4 0.0 5.4 4 2 2 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36704.1 - 3.3e-08 32.6 8.7 0.11 11.1 0.2 5.1 2 2 2 5 5 5 5 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36704.1 - 1.7e-07 30.9 8.2 0.0044 16.4 0.3 4.2 3 1 1 4 4 4 4 WD40-like domain WD40 PF00400.32 ETO36705.1 - 3.6e-44 147.9 17.4 2e-09 37.9 0.2 5.1 5 0 0 5 5 5 5 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36705.1 - 3.6e-21 75.2 2.0 1.5e-05 25.2 0.1 4.7 1 1 4 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36705.1 - 9.8e-11 41.2 0.0 0.023 13.7 0.0 4.7 1 1 4 5 5 5 4 WD40 region of Ge1, enhancer of mRNA-decapping protein eIF2A PF08662.11 ETO36705.1 - 5.6e-10 39.4 0.1 4.3e-06 26.7 0.0 2.1 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A WD40_like PF17005.5 ETO36705.1 - 1.1e-09 38.1 1.0 0.0012 18.3 0.1 2.8 1 1 2 3 3 3 3 WD40-like domain Nup160 PF11715.8 ETO36705.1 - 4.5e-07 28.9 1.1 0.4 9.3 0.0 4.2 1 1 3 4 4 4 4 Nucleoporin Nup120/160 PD40 PF07676.12 ETO36705.1 - 1.8e-06 27.7 0.4 3.4 7.7 0.0 4.6 5 0 0 5 5 5 2 WD40-like Beta Propeller Repeat DUF5474 PF17568.2 ETO36705.1 - 0.00024 21.1 0.3 0.94 9.6 0.0 2.6 1 1 0 2 2 2 2 Family of unknown function (DUF5474) PALB2_WD40 PF16756.5 ETO36705.1 - 0.011 14.7 1.7 1.4 7.7 0.0 3.2 1 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain Nbas_N PF15492.6 ETO36705.1 - 0.018 14.4 0.3 0.11 11.8 0.1 2.2 1 1 2 3 3 3 0 Neuroblastoma-amplified sequence, N terminal DPPIV_N PF00930.21 ETO36705.1 - 0.041 12.6 0.1 9.2 4.9 0.0 3.3 1 1 3 4 4 4 0 Dipeptidyl peptidase IV (DPP IV) N-terminal region Lactonase PF10282.9 ETO36705.1 - 0.06 12.6 0.0 1.9 7.7 0.0 2.7 1 1 1 3 3 3 0 Lactonase, 7-bladed beta-propeller DUF4999 PF16390.5 ETO36705.1 - 0.31 11.3 1.8 81 3.6 0.0 3.3 2 1 1 3 3 3 0 Domain of unknown function Proteasome_A_N PF10584.9 ETO36705.1 - 0.39 10.4 2.8 49 3.7 0.1 3.4 3 0 0 3 3 3 0 Proteasome subunit A N-terminal signature Kelch_4 PF13418.6 ETO36706.1 - 5e-06 26.4 0.1 0.00091 19.2 0.0 2.8 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO36706.1 - 1.7e-05 24.9 1.9 0.001 19.2 0.0 3.7 3 1 1 4 4 4 1 Kelch motif Kelch_2 PF07646.15 ETO36706.1 - 6.1e-05 22.8 0.4 0.032 14.2 0.1 3.2 2 0 0 2 2 2 1 Kelch motif Kelch_5 PF13854.6 ETO36706.1 - 0.0063 16.5 0.9 0.45 10.6 0.0 4.0 4 0 0 4 4 4 1 Kelch motif IFT46_B_C PF12317.8 ETO36706.1 - 0.0093 15.7 3.4 0.027 14.2 3.4 1.7 1 0 0 1 1 1 1 Intraflagellar transport complex B protein 46 C terminal ANAPC4_WD40 PF12894.7 ETO36706.1 - 0.012 15.8 0.0 0.051 13.9 0.0 2.1 1 0 0 1 1 1 0 Anaphase-promoting complex subunit 4 WD40 domain PD40 PF07676.12 ETO36706.1 - 0.023 14.6 0.1 7.4 6.6 0.0 3.4 3 0 0 3 3 3 0 WD40-like Beta Propeller Repeat WD40 PF00400.32 ETO36706.1 - 0.042 14.7 0.0 0.58 11.1 0.0 3.0 3 0 0 3 3 3 0 WD domain, G-beta repeat Kelch_3 PF13415.6 ETO36706.1 - 0.049 13.9 0.0 0.16 12.3 0.0 1.9 2 0 0 2 2 2 0 Galactose oxidase, central domain Kelch_1 PF01344.25 ETO36706.1 - 0.077 12.6 0.6 0.19 11.4 0.0 2.1 2 0 0 2 2 2 0 Kelch motif DUF1682 PF07946.14 ETO36709.1 - 0.29 10.3 10.9 0.36 10.0 10.9 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF1682) NPIP PF06409.11 ETO36709.1 - 0.37 9.8 4.1 0.4 9.7 4.1 1.1 1 0 0 1 1 1 0 Nuclear pore complex interacting protein (NPIP) Ank_4 PF13637.6 ETO36710.1 - 2.5e-11 43.8 0.6 1.4e-05 25.5 0.1 4.2 2 1 2 4 4 4 3 Ankyrin repeats (many copies) Ank_2 PF12796.7 ETO36710.1 - 2.2e-10 40.9 0.1 3.8e-09 37.0 0.0 2.7 1 1 1 2 2 2 1 Ankyrin repeats (3 copies) Ank_5 PF13857.6 ETO36710.1 - 6.3e-10 39.1 0.3 1.6e-08 34.6 0.0 2.8 2 1 1 3 3 3 1 Ankyrin repeats (many copies) Ank_3 PF13606.6 ETO36710.1 - 3.8e-09 36.1 0.1 6e-06 26.2 0.0 4.2 3 0 0 3 3 3 1 Ankyrin repeat Ank PF00023.30 ETO36710.1 - 1e-07 32.0 0.2 3.3e-06 27.3 0.0 3.1 3 0 0 3 3 3 1 Ankyrin repeat LRR_8 PF13855.6 ETO36711.1 - 0.021 14.6 0.4 1.5 8.7 0.0 3.2 3 0 0 3 3 3 0 Leucine rich repeat PI-TkoII_IV PF18714.1 ETO36711.1 - 0.049 13.1 0.2 0.92 9.0 0.0 2.7 3 0 0 3 3 3 0 DNA polymerase II intein Domain IV LRR_4 PF12799.7 ETO36711.1 - 0.07 13.6 4.2 25 5.5 0.0 4.2 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) TrbL PF04610.14 ETO36712.1 - 0.00014 21.7 4.7 0.0015 18.3 0.6 2.0 2 0 0 2 2 2 1 TrbL/VirB6 plasmid conjugal transfer protein RSN1_TM PF13967.6 ETO36712.1 - 0.0004 20.2 5.2 0.067 13.0 0.2 2.2 2 0 0 2 2 2 2 Late exocytosis, associated with Golgi transport Ni_hydr_CYTB PF01292.20 ETO36712.1 - 0.011 15.4 1.4 0.43 10.2 2.1 2.1 1 1 1 2 2 2 0 Prokaryotic cytochrome b561 Connexin PF00029.19 ETO36712.1 - 0.011 15.5 2.1 0.48 10.2 0.2 2.1 1 1 1 2 2 2 0 Connexin DUF2207 PF09972.9 ETO36712.1 - 0.011 14.5 5.9 0.02 13.7 5.9 1.5 1 1 0 1 1 1 0 Predicted membrane protein (DUF2207) Wzy_C_2 PF11846.8 ETO36712.1 - 0.033 14.1 0.2 0.8 9.6 0.2 2.1 2 0 0 2 2 2 0 Virulence factor membrane-bound polymerase, C-terminal Wzy_C PF04932.15 ETO36712.1 - 0.067 12.8 3.1 0.35 10.5 2.5 2.0 2 0 0 2 2 2 0 O-Antigen ligase UPF0239 PF06783.11 ETO36712.1 - 0.072 13.3 0.2 0.77 10.0 0.0 2.2 2 0 0 2 2 2 0 Uncharacterised protein family (UPF0239) tRNA_anti-like PF12869.7 ETO36712.1 - 0.087 12.4 0.3 0.67 9.6 0.0 2.1 2 1 0 2 2 2 0 tRNA_anti-like Phage_holin_3_6 PF07332.11 ETO36712.1 - 0.38 10.8 2.5 8 6.5 3.5 2.0 2 0 0 2 2 2 0 Putative Actinobacterial Holin-X, holin superfamily III EphA2_TM PF14575.6 ETO36712.1 - 0.67 10.9 4.8 12 6.8 0.1 2.7 3 0 0 3 3 2 0 Ephrin type-A receptor 2 transmembrane domain DUF2140 PF09911.9 ETO36712.1 - 0.67 9.5 10.6 0.063 12.8 1.4 2.6 3 0 0 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2140) MerC PF03203.14 ETO36712.1 - 1.5 9.3 0.0 1.5 9.3 0.0 2.5 2 1 1 3 3 3 0 MerC mercury resistance protein FixH PF05751.11 ETO36712.1 - 1.8 8.5 8.0 2.9 7.9 0.0 3.1 3 0 0 3 3 3 0 FixH Ctr PF04145.15 ETO36712.1 - 1.9 9.1 6.7 13 6.4 1.1 2.5 1 1 1 2 2 2 0 Ctr copper transporter family MetOD2 PF18548.1 ETO36713.1 - 0.036 14.2 0.4 0.095 12.8 0.4 1.7 1 0 0 1 1 1 0 Metanogen output domain 2 ubiquitin PF00240.23 ETO36715.1 - 1.2e-12 47.4 0.2 3.9e-12 45.7 0.2 1.8 1 0 0 1 1 1 1 Ubiquitin family Rad60-SLD PF11976.8 ETO36715.1 - 0.002 17.9 0.1 0.002 17.9 0.1 2.7 3 1 0 3 3 3 1 Ubiquitin-2 like Rad60 SUMO-like DDE_Tnp_1_6 PF13751.6 ETO36715.1 - 0.054 13.7 2.1 0.3 11.3 0.0 2.1 1 1 0 2 2 2 0 Transposase DDE domain Osmo_CC PF08946.10 ETO36715.1 - 0.74 10.1 5.2 1 9.7 1.5 2.5 2 0 0 2 2 2 0 Osmosensory transporter coiled coil Goodbye PF17109.5 ETO36715.1 - 2.9 8.4 7.4 23 5.5 0.1 2.3 1 1 0 2 2 2 0 fungal STAND N-terminal Goodbye domain AzlD PF05437.12 ETO36716.1 - 0.21 11.8 4.6 0.53 10.5 4.6 1.7 1 0 0 1 1 1 0 Branched-chain amino acid transport protein (AzlD) SATase_N PF06426.14 ETO36717.1 - 0.035 14.5 0.4 3.8 8.0 0.2 2.2 2 0 0 2 2 2 0 Serine acetyltransferase, N-terminal DUF1319 PF07028.11 ETO36718.1 - 0.0086 16.3 2.9 0.016 15.4 2.9 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF1319) zf-C4pol PF14260.6 ETO36718.1 - 0.28 11.7 2.8 10 6.7 0.2 2.3 1 1 0 2 2 2 0 C4-type zinc-finger of DNA polymerase delta WD40 PF00400.32 ETO36719.1 - 5.6e-07 30.1 3.0 3.2e-05 24.6 0.4 2.6 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO36719.1 - 0.011 14.4 0.0 0.013 14.2 0.0 1.2 1 0 0 1 1 1 0 Nucleoporin Nup120/160 Orthoreo_P17 PF07272.11 ETO36720.1 - 0.0038 17.2 1.0 1.7 8.7 0.0 2.4 1 1 1 2 2 2 2 Orthoreovirus P17 protein SelP_N PF04592.14 ETO36721.1 - 3.3 7.0 25.2 7.1 6.0 25.2 1.5 1 0 0 1 1 1 0 Selenoprotein P, N terminal region F5_F8_type_C PF00754.25 ETO36722.1 - 1.2e-06 28.6 5.7 0.0061 16.7 0.1 3.0 3 0 0 3 3 3 2 F5/8 type C domain Stn1_C PF12659.7 ETO36722.1 - 0.072 13.0 0.2 6.5 6.7 0.0 2.4 2 0 0 2 2 2 0 Telomere capping C-terminal wHTH DUF2399 PF09664.10 ETO36722.1 - 0.087 12.7 0.0 0.15 12.0 0.0 1.4 1 0 0 1 1 1 0 Protein of unknown function C-terminus (DUF2399) RsfS PF02410.15 ETO36722.1 - 0.13 12.8 0.7 4.8 7.7 0.0 3.2 3 0 0 3 3 3 0 Ribosomal silencing factor during starvation DUF5000 PF16391.5 ETO36722.1 - 1.4 9.0 7.2 1.2 9.3 1.4 2.9 2 2 0 2 2 2 0 Domain of unknown function F5_F8_type_C PF00754.25 ETO36723.1 - 5.8e-10 39.4 1.0 0.00023 21.2 0.4 2.3 2 0 0 2 2 2 2 F5/8 type C domain zf-RING_2 PF13639.6 ETO36723.1 - 1.8e-05 24.9 4.1 1.8e-05 24.9 4.1 5.4 7 1 0 7 7 7 1 Ring finger domain zf-RING_11 PF17123.5 ETO36723.1 - 2.2e-05 24.1 4.5 9.6e-05 22.0 4.5 2.2 1 0 0 1 1 1 1 RING-like zinc finger zf-rbx1 PF12678.7 ETO36723.1 - 0.00017 21.8 1.7 0.00017 21.8 1.7 4.2 4 1 1 5 5 5 1 RING-H2 zinc finger domain zf-RING_5 PF14634.6 ETO36723.1 - 0.00038 20.4 2.9 0.00038 20.4 2.9 4.0 5 1 0 5 5 5 1 zinc-RING finger domain HepII_C PF18675.1 ETO36723.1 - 0.063 13.4 0.4 0.24 11.5 0.1 2.0 2 0 0 2 2 2 0 Heparinase II C-terminal domain PH PF00169.29 ETO36724.1 - 0.0024 18.3 0.0 0.0029 18.1 0.0 1.1 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ETO36724.1 - 0.0025 18.1 0.0 0.0035 17.6 0.0 1.2 1 0 0 1 1 1 1 Pleckstrin homology domain Sec3-PIP2_bind PF15277.6 ETO36724.1 - 0.028 14.5 0.0 0.041 14.0 0.0 1.3 1 0 0 1 1 1 0 Exocyst complex component SEC3 N-terminal PIP2 binding PH PH_13 PF16652.5 ETO36724.1 - 0.03 14.1 0.0 0.035 13.9 0.0 1.2 1 0 0 1 1 1 0 Pleckstrin homology domain PH_9 PF15410.6 ETO36724.1 - 0.047 14.1 0.0 0.067 13.6 0.0 1.3 1 0 0 1 1 1 0 Pleckstrin homology domain ETRAMP PF09716.10 ETO36725.1 - 0.022 14.8 3.8 0.078 13.0 0.1 2.5 2 0 0 2 2 2 0 Malarial early transcribed membrane protein (ETRAMP) RVT_1 PF00078.27 ETO36726.1 - 1.3e-12 47.7 0.2 7e-11 42.1 0.2 2.1 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) Vps16_C PF04840.12 ETO36727.1 - 9.1e-20 70.9 1.9 9.9e-20 70.8 1.9 1.0 1 0 0 1 1 1 1 Vps16, C-terminal region Clathrin PF00637.20 ETO36727.1 - 5.7e-05 23.0 1.4 8.5e-05 22.4 1.4 1.4 1 1 0 1 1 1 1 Region in Clathrin and VPS DUF2309 PF10070.9 ETO36727.1 - 0.0039 15.6 1.7 0.0044 15.4 1.7 1.0 1 0 0 1 1 1 1 Uncharacterized protein conserved in bacteria (DUF2309) RNR_N PF08343.10 ETO36727.1 - 0.022 14.8 1.4 0.086 12.9 0.1 2.4 3 0 0 3 3 3 0 Ribonucleotide reductase N-terminal DUF1195 PF06708.11 ETO36727.1 - 0.069 12.9 0.2 0.069 12.9 0.2 1.5 2 0 0 2 2 2 0 Protein of unknown function (DUF1195) Peptidase_M60 PF13402.6 ETO36727.1 - 0.16 11.5 1.0 0.25 10.8 0.3 1.5 1 1 1 2 2 2 0 Peptidase M60, enhancin and enhancin-like E1_DerP2_DerF2 PF02221.15 ETO36728.1 - 1e-13 51.8 3.8 1.3e-13 51.5 3.8 1.1 1 0 0 1 1 1 1 ML domain TRP_N PF14558.6 ETO36728.1 - 2.2e-05 24.8 2.2 0.0001 22.7 1.8 2.1 1 1 1 2 2 2 1 ML-like domain PKD_channel PF08016.12 ETO36729.1 - 0.0013 17.5 0.4 0.0017 17.1 0.4 1.1 1 0 0 1 1 1 1 Polycystin cation channel Kelch_6 PF13964.6 ETO36730.1 - 2.1e-07 30.9 0.2 0.14 12.5 0.0 3.8 2 1 1 3 3 3 3 Kelch motif Kelch_2 PF07646.15 ETO36730.1 - 2.8e-07 30.2 3.3 0.00063 19.6 0.1 4.6 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO36730.1 - 3.2e-06 26.6 0.4 0.0026 17.3 0.1 4.1 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO36730.1 - 0.00058 19.8 0.0 0.012 15.7 0.0 2.6 2 0 0 2 2 2 1 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO36730.1 - 0.022 14.7 0.1 8.5 6.5 0.2 4.1 4 0 0 4 4 4 0 Kelch motif Kelch_3 PF13415.6 ETO36730.1 - 0.031 14.6 0.0 0.62 10.4 0.0 3.0 4 0 0 4 4 4 0 Galactose oxidase, central domain EPL1 PF10513.9 ETO36731.1 - 0.032 14.6 0.6 0.032 14.6 0.6 1.2 1 1 0 1 1 1 0 Enhancer of polycomb-like NMT PF01233.19 ETO36732.1 - 0.034 14.0 2.4 0.16 11.8 0.4 2.1 2 0 0 2 2 2 0 Myristoyl-CoA:protein N-myristoyltransferase, N-terminal domain TPR_12 PF13424.6 ETO36733.1 - 8.2e-32 109.3 4.4 9.7e-14 51.4 1.4 2.8 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36733.1 - 3.8e-16 58.4 0.0 2.5e-06 27.1 0.1 4.3 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36733.1 - 1.5e-14 53.0 13.0 1e-05 25.1 1.7 3.9 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36733.1 - 7.5e-13 47.5 1.5 0.0026 17.7 0.0 4.4 3 1 1 4 4 4 3 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36733.1 - 5.6e-12 44.9 14.3 9.1e-05 22.4 1.4 4.1 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36733.1 - 9.4e-12 44.1 10.6 0.0021 18.0 0.9 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36733.1 - 0.0021 17.7 8.4 0.98 9.2 0.0 4.9 4 2 2 6 6 6 1 TPR repeat TPR_17 PF13431.6 ETO36733.1 - 0.0023 18.2 6.5 5 7.7 0.1 4.6 4 1 0 4 4 4 1 Tetratricopeptide repeat MIT PF04212.18 ETO36733.1 - 0.003 17.6 4.3 1.3 9.1 0.1 3.8 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain TPR_14 PF13428.6 ETO36733.1 - 0.0051 17.5 0.3 3.1 8.8 0.0 4.1 4 1 1 5 5 5 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36733.1 - 0.0059 17.2 5.8 0.62 10.8 0.2 3.2 4 0 0 4 4 3 2 Tetratricopeptide repeat HTH_Bact PF18768.1 ETO36733.1 - 0.03 13.9 0.6 2.1 8.0 0.1 2.9 3 0 0 3 3 3 0 Helix-turn-helix bacterial domain DUF2225 PF09986.9 ETO36733.1 - 0.13 11.9 4.9 0.042 13.6 1.1 2.1 2 1 1 3 3 3 0 Uncharacterized protein conserved in bacteria (DUF2225) INSIG PF07281.12 ETO36734.1 - 0.038 13.6 0.2 0.049 13.3 0.2 1.1 1 0 0 1 1 1 0 Insulin-induced protein (INSIG) RTBV_P12 PF06361.11 ETO36736.1 - 0.0022 18.4 1.1 0.0033 17.8 0.5 1.5 1 1 0 1 1 1 1 Rice tungro bacilliform virus P12 protein EF-hand_7 PF13499.6 ETO36736.1 - 0.065 13.7 2.6 0.73 10.3 0.2 2.2 2 0 0 2 2 2 0 EF-hand domain pair XhlA PF10779.9 ETO36736.1 - 0.083 13.1 0.9 0.083 13.1 0.9 2.6 2 2 0 2 2 2 0 Haemolysin XhlA WD40 PF00400.32 ETO36737.1 - 4.4e-06 27.3 0.9 0.13 13.2 0.1 3.1 3 0 0 3 3 3 2 WD domain, G-beta repeat DUF3504 PF12012.8 ETO36739.1 - 0.56 10.1 6.0 0.7 9.8 6.0 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF3504) Drc1-Sld2 PF11719.8 ETO36739.1 - 1.2 8.6 15.3 1.3 8.5 15.3 1.0 1 0 0 1 1 1 0 DNA replication and checkpoint protein NPR3 PF03666.13 ETO36739.1 - 5.3 5.7 10.0 6.4 5.4 10.0 1.0 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 EMC3_TMCO1 PF01956.16 ETO36739.1 - 7.1 6.3 5.7 9.4 5.9 5.7 1.1 1 0 0 1 1 1 0 Integral membrane protein EMC3/TMCO1-like WD40 PF00400.32 ETO36740.1 - 9.8e-18 64.2 4.5 5.7e-05 23.8 0.1 3.7 4 0 0 4 4 4 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36740.1 - 3.8e-05 23.9 0.1 0.34 11.2 0.0 3.1 2 1 1 3 3 3 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36740.1 - 6.2e-05 21.8 0.5 1 7.9 0.0 3.0 1 1 1 3 3 3 3 Nucleoporin Nup120/160 BBS2_Mid PF14783.6 ETO36740.1 - 0.0077 16.3 1.0 0.2 11.7 0.2 2.4 1 1 0 2 2 2 1 Ciliary BBSome complex subunit 2, middle region WD40_like PF17005.5 ETO36740.1 - 0.019 14.3 0.7 1.5 8.1 0.0 2.8 1 1 2 3 3 3 0 WD40-like domain SelR PF01641.18 ETO36743.1 - 2e-31 108.6 1.1 2.8e-31 108.1 1.1 1.2 1 0 0 1 1 1 1 SelR domain Yippee-Mis18 PF03226.14 ETO36743.1 - 0.0016 18.7 2.4 0.0047 17.1 2.4 1.7 1 1 0 1 1 1 1 Yippee zinc-binding/DNA-binding /Mis18, centromere assembly Tnp_zf-ribbon_2 PF13842.6 ETO36743.1 - 1.2 10.0 5.2 0.99 10.3 0.3 2.5 3 0 0 3 3 3 0 DDE_Tnp_1-like zinc-ribbon APG6_N PF17675.1 ETO36745.1 - 2.8e-07 31.2 77.1 0.063 13.8 20.7 4.6 2 1 2 4 4 4 4 Apg6 coiled-coil region ERM PF00769.19 ETO36745.1 - 8.5e-06 25.8 74.0 0.01 15.6 16.7 3.5 2 1 1 3 3 3 3 Ezrin/radixin/moesin family CALCOCO1 PF07888.11 ETO36745.1 - 6.5e-05 22.0 60.1 7.4e-05 21.8 46.6 2.1 2 0 0 2 2 2 2 Calcium binding and coiled-coil domain (CALCOCO1) like Myosin_tail_1 PF01576.19 ETO36745.1 - 0.0002 19.3 32.6 0.0002 19.3 32.6 3.0 1 1 1 2 2 1 1 Myosin tail TMF_TATA_bd PF12325.8 ETO36745.1 - 0.00034 20.8 64.4 0.026 14.7 3.8 5.1 2 1 3 5 5 5 2 TATA element modulatory factor 1 TATA binding KASH_CCD PF14662.6 ETO36745.1 - 0.002 18.0 70.9 0.049 13.5 30.2 4.5 1 1 2 3 3 3 1 Coiled-coil region of CCDC155 or KASH DMPK_coil PF08826.10 ETO36745.1 - 0.0049 16.9 1.0 0.0049 16.9 1.0 6.8 4 2 2 6 6 4 1 DMPK coiled coil domain like Val_tRNA-synt_C PF10458.9 ETO36745.1 - 0.0099 16.1 1.4 0.0099 16.1 1.4 7.1 5 3 1 6 6 6 2 Valyl tRNA synthetase tRNA binding arm Spc7 PF08317.11 ETO36745.1 - 0.013 14.4 74.6 0.065 12.1 28.6 3.4 2 1 1 3 3 3 0 Spc7 kinetochore protein DUF1664 PF07889.12 ETO36745.1 - 0.013 15.6 7.4 0.013 15.6 7.4 4.5 2 1 2 4 4 4 0 Protein of unknown function (DUF1664) Paralemmin PF03285.15 ETO36745.1 - 0.015 14.9 6.9 0.015 14.9 6.9 4.0 2 1 1 3 3 2 0 Paralemmin CENP-F_leu_zip PF10473.9 ETO36745.1 - 0.018 15.0 69.0 0.95 9.5 30.9 4.6 2 1 2 4 4 4 0 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 ATG16 PF08614.11 ETO36745.1 - 0.043 14.0 75.6 3.6 7.8 42.2 4.3 1 1 3 4 4 4 0 Autophagy protein 16 (ATG16) GAS PF13851.6 ETO36745.1 - 0.043 13.1 72.7 0.58 9.5 24.1 4.9 2 1 3 5 5 5 0 Growth-arrest specific micro-tubule binding Golgin_A5 PF09787.9 ETO36745.1 - 0.057 12.9 71.5 0.36 10.2 26.3 3.5 2 1 2 4 4 4 0 Golgin subfamily A member 5 DUF724 PF05266.14 ETO36745.1 - 0.097 12.5 61.1 0.31 10.9 8.7 4.2 2 1 2 4 4 4 0 Protein of unknown function (DUF724) Fez1 PF06818.15 ETO36745.1 - 0.24 11.8 65.2 3.2 8.2 31.6 3.8 1 1 3 4 4 4 0 Fez1 YabA PF06156.13 ETO36745.1 - 0.32 11.7 63.0 2.1 9.1 5.8 5.8 2 2 4 6 6 6 0 Initiation control protein YabA TPR_MLP1_2 PF07926.12 ETO36745.1 - 0.37 10.9 77.7 1.5 8.9 21.9 4.6 2 1 2 4 4 4 0 TPR/MLP1/MLP2-like protein DUF2968 PF11180.8 ETO36745.1 - 0.4 10.3 67.5 0.13 11.9 11.8 5.0 2 1 2 5 5 5 0 Protein of unknown function (DUF2968) ZapB PF06005.12 ETO36745.1 - 0.42 11.1 82.1 0.51 10.8 7.5 6.3 2 1 2 4 4 2 0 Cell division protein ZapB PRKG1_interact PF15898.5 ETO36745.1 - 0.49 11.3 66.3 0.043 14.7 18.6 4.6 2 2 1 4 4 4 0 cGMP-dependent protein kinase interacting domain DUF4200 PF13863.6 ETO36745.1 - 0.54 10.7 67.9 0.2 12.0 16.0 5.4 2 2 4 6 6 6 0 Domain of unknown function (DUF4200) HMMR_N PF15905.5 ETO36745.1 - 0.58 9.6 73.6 0.11 11.9 32.3 3.3 2 1 1 3 3 3 0 Hyaluronan mediated motility receptor N-terminal CENP-H PF05837.12 ETO36745.1 - 0.59 10.6 68.7 0.53 10.7 6.0 5.4 2 1 4 6 6 6 0 Centromere protein H (CENP-H) COG2 PF06148.11 ETO36745.1 - 0.79 9.8 39.4 1.4 9.0 11.5 4.7 2 1 2 4 4 4 0 COG (conserved oligomeric Golgi) complex component, COG2 SHE3 PF17078.5 ETO36745.1 - 1.4 8.5 59.8 2.5 7.7 30.1 3.7 2 1 1 3 3 3 0 SWI5-dependent HO expression protein 3 Jnk-SapK_ap_N PF09744.9 ETO36745.1 - 1.5 9.0 72.8 2.9 8.1 8.9 4.5 2 1 2 4 4 4 0 JNK_SAPK-associated protein-1 FUSC PF04632.12 ETO36745.1 - 1.6 7.1 13.9 0.31 9.5 5.6 2.2 1 1 1 2 2 2 0 Fusaric acid resistance protein family WEMBL PF05701.11 ETO36745.1 - 2 7.0 56.0 1.4 7.5 42.6 2.2 2 0 0 2 2 2 0 Weak chloroplast movement under blue light DUF4407 PF14362.6 ETO36745.1 - 2.2 7.6 58.5 0.6 9.4 24.5 3.2 1 1 2 3 3 3 0 Domain of unknown function (DUF4407) ADIP PF11559.8 ETO36745.1 - 2.7 8.1 78.7 0.18 11.9 9.2 5.0 2 1 4 6 6 6 0 Afadin- and alpha -actinin-Binding HAP1_N PF04849.13 ETO36745.1 - 3.1 6.9 65.3 2.4 7.3 17.7 4.3 2 1 2 4 4 4 0 HAP1 N-terminal conserved region AAA_13 PF13166.6 ETO36745.1 - 3.3 6.2 65.0 0.076 11.6 37.2 3.0 2 1 1 3 3 3 0 AAA domain DUF5082 PF16888.5 ETO36745.1 - 3.6 7.9 66.6 0.043 14.1 13.4 5.2 2 1 3 5 5 5 0 Domain of unknown function (DUF5082) Uso1_p115_C PF04871.13 ETO36745.1 - 3.7 7.9 76.5 0.33 11.3 13.2 5.0 2 1 2 4 4 4 0 Uso1 / p115 like vesicle tethering protein, C terminal region Filament PF00038.21 ETO36745.1 - 4.9 6.7 60.4 38 3.7 47.4 3.1 1 1 1 2 2 2 0 Intermediate filament protein Nup54 PF13874.6 ETO36745.1 - 4.9 7.3 51.5 0.027 14.6 6.5 4.4 2 1 1 4 4 4 0 Nucleoporin complex subunit 54 Tektin PF03148.14 ETO36745.1 - 6.8 5.3 60.6 0.68 8.6 5.6 5.2 2 1 3 5 5 5 0 Tektin family ESM4 PF15952.5 ETO36746.1 - 0.61 10.5 17.3 0.87 10.0 17.3 1.3 1 0 0 1 1 1 0 Enhancer of split M4 family HSM3_C PF18794.1 ETO36747.1 - 0.0032 17.1 0.1 0.0055 16.3 0.1 1.4 1 0 0 1 1 1 1 DNA mismatch repair protein HSM3, C terminal domain adh_short PF00106.25 ETO36748.1 - 2.9e-23 82.3 1.0 7.2e-18 64.7 0.6 3.1 2 1 0 2 2 2 2 short chain dehydrogenase adh_short_C2 PF13561.6 ETO36748.1 - 4.1e-10 39.6 0.1 9.9e-08 31.8 0.0 2.8 1 1 1 2 2 2 2 Enoyl-(Acyl carrier protein) reductase KR PF08659.10 ETO36748.1 - 3.5e-06 27.1 0.2 6.1e-06 26.3 0.2 1.3 1 0 0 1 1 1 1 KR domain Sacchrp_dh_NADP PF03435.18 ETO36748.1 - 0.0099 16.1 0.1 0.022 15.0 0.1 1.6 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain F420_oxidored PF03807.17 ETO36748.1 - 0.052 14.1 0.5 0.098 13.2 0.5 1.4 1 0 0 1 1 1 0 NADP oxidoreductase coenzyme F420-dependent LDcluster4 PF18306.1 ETO36748.1 - 0.069 12.7 0.3 0.11 12.1 0.3 1.2 1 0 0 1 1 1 0 SLOG cluster4 family CobD_Cbib PF03186.13 ETO36748.1 - 0.18 11.0 0.0 0.28 10.4 0.0 1.2 1 0 0 1 1 1 0 CobD/Cbib protein Methyltransf_31 PF13847.6 ETO36751.1 - 1.2e-15 57.6 0.4 1.9e-15 57.0 0.4 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_25 PF13649.6 ETO36751.1 - 5.6e-11 43.0 0.0 8.8e-11 42.4 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_11 PF08241.12 ETO36751.1 - 3.1e-09 37.4 0.0 4.6e-09 36.8 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_12 PF08242.12 ETO36751.1 - 2e-07 31.7 0.0 3.5e-07 30.9 0.0 1.4 1 0 0 1 1 1 1 Methyltransferase domain Ubie_methyltran PF01209.18 ETO36751.1 - 2e-07 30.6 0.0 2.8e-07 30.1 0.0 1.1 1 0 0 1 1 1 1 ubiE/COQ5 methyltransferase family Methyltransf_4 PF02390.17 ETO36751.1 - 4.6e-07 29.5 0.0 6.6e-07 28.9 0.0 1.2 1 0 0 1 1 1 1 Putative methyltransferase Methyltransf_23 PF13489.6 ETO36751.1 - 8e-06 25.8 0.0 9.9e-06 25.5 0.0 1.2 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_32 PF13679.6 ETO36751.1 - 0.00061 19.8 0.0 0.00088 19.3 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain Methyltransf_18 PF12847.7 ETO36751.1 - 0.0019 18.1 0.0 0.0029 17.6 0.0 1.3 1 0 0 1 1 1 1 Methyltransferase domain FtsJ PF01728.19 ETO36751.1 - 0.0038 17.3 0.0 0.0061 16.7 0.0 1.2 1 0 0 1 1 1 1 FtsJ-like methyltransferase MTS PF05175.14 ETO36751.1 - 0.0079 15.8 0.0 0.018 14.6 0.0 1.5 1 1 1 2 2 2 1 Methyltransferase small domain Methyltransf_PK PF05891.12 ETO36751.1 - 0.028 13.9 0.0 0.039 13.5 0.0 1.2 1 0 0 1 1 1 0 AdoMet dependent proline di-methyltransferase Methyltransf_9 PF08003.11 ETO36751.1 - 0.042 12.8 0.0 0.063 12.2 0.0 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF1698) PCMT PF01135.19 ETO36751.1 - 0.044 13.5 0.0 0.058 13.1 0.0 1.2 1 0 0 1 1 1 0 Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT) PrmA PF06325.13 ETO36751.1 - 0.12 11.7 0.0 0.16 11.3 0.0 1.1 1 0 0 1 1 1 0 Ribosomal protein L11 methyltransferase (PrmA) WD40 PF00400.32 ETO36752.1 - 3.8e-38 128.8 27.2 6e-07 30.1 0.3 7.2 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36752.1 - 2.1e-11 43.9 1.6 0.17 12.2 0.0 5.6 4 1 1 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain DUF2304 PF10066.9 ETO36752.1 - 0.033 14.4 0.8 0.033 14.4 0.8 1.9 2 0 0 2 2 2 0 Uncharacterized conserved protein (DUF2304) LysE PF01810.18 ETO36752.1 - 0.09 12.2 0.1 0.18 11.2 0.1 1.5 1 1 0 1 1 1 0 LysE type translocator Gal_Lectin PF02140.18 ETO36752.1 - 0.25 11.8 3.8 13 6.3 0.0 3.8 4 0 0 4 4 4 0 Galactose binding lectin domain WD40 PF00400.32 ETO36753.1 - 4e-58 192.0 28.8 5.3e-09 36.6 1.6 9.3 9 0 0 9 9 9 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36753.1 - 1.4e-22 79.8 2.3 0.0011 19.2 0.1 7.9 3 1 4 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36753.1 - 1.3e-12 47.4 2.8 0.4 9.6 0.0 7.4 2 1 6 8 8 8 4 WD40 region of Ge1, enhancer of mRNA-decapping protein Kelch_6 PF13964.6 ETO36753.1 - 0.00011 22.4 2.7 0.0048 17.1 0.1 3.9 4 0 0 4 4 4 1 Kelch motif PD40 PF07676.12 ETO36753.1 - 0.0012 18.7 3.1 1.3 9.1 0.1 5.0 5 0 0 5 5 5 1 WD40-like Beta Propeller Repeat HARP PF07443.13 ETO36753.1 - 0.049 13.3 0.6 15 5.3 0.0 3.5 4 0 0 4 4 4 0 HepA-related protein (HARP) Nucleoporin_N PF08801.11 ETO36753.1 - 0.05 12.3 5.8 1.5 7.4 0.0 3.8 1 1 2 3 3 3 0 Nup133 N terminal like Kelch_3 PF13415.6 ETO36753.1 - 0.078 13.3 0.0 0.41 11.0 0.0 2.3 1 0 0 1 1 1 0 Galactose oxidase, central domain Cwf_Cwc_15 PF04889.12 ETO36753.1 - 0.12 12.1 8.0 7.3 6.2 5.3 2.3 2 0 0 2 2 2 0 Cwf15/Cwc15 cell cycle control protein Proteasome_A_N PF10584.9 ETO36753.1 - 0.41 10.4 4.9 7.7 6.3 0.0 4.4 5 0 0 5 5 5 0 Proteasome subunit A N-terminal signature TPR_12 PF13424.6 ETO36754.1 - 1.5e-37 127.7 13.3 4e-14 52.7 0.5 4.3 2 1 3 5 5 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36754.1 - 1.8e-21 74.5 4.7 1.2e-05 24.9 0.2 5.0 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36754.1 - 5.4e-21 73.8 2.2 8.3e-06 25.5 0.1 5.8 5 1 0 5 5 5 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36754.1 - 9.8e-21 72.7 27.4 5.3e-07 29.2 0.9 5.0 5 0 0 5 5 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36754.1 - 4.9e-17 60.7 21.8 2.7e-05 24.0 1.6 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36754.1 - 8.7e-16 56.7 24.1 9.5e-05 22.2 1.5 5.1 5 0 0 5 5 5 4 Tetratricopeptide repeat Peptidase_C14 PF00656.22 ETO36754.1 - 3.4e-11 43.6 0.2 6.9e-11 42.6 0.2 1.4 1 0 0 1 1 1 1 Caspase domain SNAP PF14938.6 ETO36754.1 - 4.7e-09 36.1 4.4 4.7e-09 36.1 4.4 1.9 2 0 0 2 2 1 1 Soluble NSF attachment protein, SNAP TPR_6 PF13174.6 ETO36754.1 - 6.1e-07 29.7 5.7 2.7 8.8 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36754.1 - 3.8e-06 26.5 24.4 0.02 14.6 5.3 6.8 5 1 1 6 6 6 2 TPR repeat TPR_17 PF13431.6 ETO36754.1 - 1.8e-05 24.8 0.9 0.052 13.9 0.0 4.3 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36754.1 - 5.1e-05 23.7 0.5 3.4 8.7 0.0 3.7 3 0 0 3 3 3 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36754.1 - 7.7e-05 23.3 0.3 0.03 15.0 0.1 3.0 2 1 0 2 2 2 1 Tetratricopeptide repeat CinA_KH PF18146.1 ETO36754.1 - 0.00048 20.2 0.0 1.8 8.8 0.0 3.2 2 1 1 3 3 3 2 Damage-inducible protein CinA KH domain DUF2225 PF09986.9 ETO36754.1 - 0.0027 17.5 9.4 11 5.7 0.1 3.6 1 1 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2225) TPR_19 PF14559.6 ETO36754.1 - 0.0032 18.0 1.8 0.0072 16.8 0.4 2.2 2 0 0 2 2 2 1 Tetratricopeptide repeat SHNi-TPR PF10516.9 ETO36754.1 - 0.012 15.0 0.5 9 5.8 0.0 3.3 3 0 0 3 3 3 0 SHNi-TPR ANAPC3 PF12895.7 ETO36754.1 - 0.036 14.3 5.2 2.6 8.3 5.2 3.0 1 1 0 1 1 1 0 Anaphase-promoting complex, cyclosome, subunit 3 MIT PF04212.18 ETO36754.1 - 0.15 12.1 9.9 6.9 6.8 0.1 4.8 2 2 2 4 4 4 0 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO36754.1 - 0.53 10.3 11.0 2.4 8.2 1.0 3.4 3 0 0 3 3 3 0 Tetratricopeptide repeat DUF5113 PF17140.4 ETO36754.1 - 1.2 8.9 7.7 19 5.0 0.5 3.6 2 2 1 3 3 3 0 Domain of unknown function (DUF5113) Rho_GDI PF02115.17 ETO36755.1 - 7e-54 182.5 1.5 8.5e-54 182.3 1.5 1.0 1 0 0 1 1 1 1 RHO protein GDP dissociation inhibitor Ligase_CoA PF00549.19 ETO36756.1 - 8.2e-24 84.2 0.9 1.1e-23 83.8 0.2 1.5 2 0 0 2 2 2 1 CoA-ligase CoA_binding PF02629.19 ETO36756.1 - 1.1e-21 77.3 1.2 6.5e-21 74.8 0.1 2.3 2 0 0 2 2 2 1 CoA binding domain Succ_CoA_lig PF13607.6 ETO36756.1 - 2.2e-08 34.0 0.0 3.6e-08 33.3 0.0 1.3 1 0 0 1 1 1 1 Succinyl-CoA ligase like flavodoxin domain His_Phos_1 PF00300.22 ETO36757.1 - 1.7e-23 83.3 0.0 6.5e-23 81.4 0.0 1.9 2 0 0 2 2 2 1 Histidine phosphatase superfamily (branch 1) zf-C3HC4 PF00097.25 ETO36757.1 - 0.67 9.9 6.8 0.15 12.0 2.0 2.5 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) FYVE PF01363.21 ETO36757.1 - 1.1 9.4 8.7 2.5 8.3 6.6 2.6 1 1 1 2 2 2 0 FYVE zinc finger FGGY_N PF00370.21 ETO36759.1 - 2.7e-43 148.3 1.9 3.7e-43 147.9 1.9 1.1 1 0 0 1 1 1 1 FGGY family of carbohydrate kinases, N-terminal domain Metallophos PF00149.28 ETO36760.1 - 3.1e-05 24.6 1.0 5.9e-05 23.7 1.0 1.5 1 1 0 1 1 1 1 Calcineurin-like phosphoesterase Gtr1_RagA PF04670.12 ETO36760.1 - 0.057 12.8 0.1 0.095 12.0 0.1 1.3 1 0 0 1 1 1 0 Gtr1/RagA G protein conserved region LRRNT_2 PF08263.12 ETO36762.1 - 0.00054 20.2 0.3 0.0013 19.0 0.3 1.7 1 0 0 1 1 1 1 Leucine rich repeat N-terminal domain LRR_4 PF12799.7 ETO36762.1 - 0.032 14.6 9.8 3.8 8.1 0.3 3.6 4 0 0 4 4 4 0 Leucine Rich repeats (2 copies) LRR_8 PF13855.6 ETO36762.1 - 0.31 10.9 6.1 8.4 6.2 0.1 3.6 4 1 0 4 4 4 0 Leucine rich repeat LRR_1 PF00560.33 ETO36762.1 - 9.8 7.2 10.4 14 6.7 0.1 4.4 4 0 0 4 4 4 0 Leucine Rich Repeat LRR_8 PF13855.6 ETO36763.1 - 0.00023 20.8 1.5 0.00023 20.8 1.5 3.9 4 0 0 4 4 4 2 Leucine rich repeat LRR_4 PF12799.7 ETO36763.1 - 0.0056 17.1 2.8 0.0056 17.1 2.8 5.3 3 2 2 5 5 5 3 Leucine Rich repeats (2 copies) LRR_1 PF00560.33 ETO36763.1 - 0.93 10.3 22.4 6.2 7.8 0.0 6.9 6 0 0 6 6 6 0 Leucine Rich Repeat Cwf_Cwc_15 PF04889.12 ETO36764.1 - 0.063 13.0 5.2 0.08 12.7 5.2 1.1 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF4200 PF13863.6 ETO36764.1 - 0.11 12.9 3.9 0.18 12.2 3.9 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF4200) F_actin_cap_B PF01115.17 ETO36765.1 - 5.9e-88 294.5 0.1 7.3e-88 294.2 0.1 1.1 1 0 0 1 1 1 1 F-actin capping protein, beta subunit DUF3644 PF12358.8 ETO36765.1 - 0.15 12.5 0.1 0.56 10.7 0.1 2.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3644) WD40 PF00400.32 ETO36766.1 - 3.7e-64 211.1 28.9 5.2e-11 42.9 0.2 7.3 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36766.1 - 4.3e-23 81.4 1.5 0.00049 20.4 0.0 6.1 1 1 5 6 6 6 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36766.1 - 6.3e-12 45.1 2.3 0.13 11.2 0.0 6.4 1 1 6 7 7 7 4 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36766.1 - 2e-07 30.6 3.4 0.016 14.6 0.0 4.1 2 1 3 6 6 6 3 WD40-like domain Cytochrom_D1 PF02239.16 ETO36766.1 - 0.00064 18.3 0.6 0.47 8.9 0.1 2.7 1 1 2 3 3 3 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO36766.1 - 0.0011 18.8 9.1 3.8 7.6 0.2 5.7 7 0 0 7 7 7 1 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO36766.1 - 0.0028 16.5 4.4 0.14 10.9 0.0 3.3 1 1 2 3 3 3 2 Nup133 N terminal like Gmad1 PF10647.9 ETO36766.1 - 0.0093 15.8 0.5 0.24 11.1 0.5 2.7 1 1 1 2 2 2 1 Lipoprotein LpqB beta-propeller domain PQQ PF01011.21 ETO36766.1 - 0.086 12.8 0.1 13 5.9 0.0 3.9 5 1 1 6 6 6 0 PQQ enzyme repeat Resistin PF06954.11 ETO36766.1 - 0.32 11.6 2.1 28 5.4 0.0 3.9 3 1 1 4 4 4 0 Resistin WD40 PF00400.32 ETO36767.1 - 8.6e-13 48.6 7.1 1.3e-05 25.9 0.2 3.3 3 0 0 3 3 3 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36767.1 - 0.00092 19.5 0.0 0.0083 16.4 0.0 2.2 2 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36767.1 - 0.001 18.5 1.6 0.0046 16.3 1.7 1.8 1 1 1 2 2 2 1 WD40-like domain DUF4221 PF13970.6 ETO36767.1 - 0.0017 18.0 3.1 0.0023 17.6 3.1 1.2 1 0 0 1 1 1 1 Domain of unknown function (DUF4221) Nup160 PF11715.8 ETO36767.1 - 0.0045 15.7 0.2 0.58 8.7 0.0 2.0 1 1 1 2 2 2 2 Nucleoporin Nup120/160 tRNA-synt_His PF13393.6 ETO36768.1 - 2.8e-31 108.9 0.0 4.1e-31 108.4 0.0 1.2 1 0 0 1 1 1 1 Histidyl-tRNA synthetase HGTP_anticodon PF03129.20 ETO36768.1 - 6.6e-06 26.2 0.1 2.4e-05 24.4 0.1 2.0 1 0 0 1 1 1 1 Anticodon binding domain tRNA-synt_2d PF01409.20 ETO36768.1 - 0.0057 16.2 0.0 0.0093 15.5 0.0 1.3 1 0 0 1 1 1 1 tRNA synthetases class II core domain (F) Peptidase_C37 PF05416.12 ETO36768.1 - 0.015 13.9 0.2 0.025 13.1 0.2 1.3 1 0 0 1 1 1 0 Southampton virus-type processing peptidase DUF1768 PF08719.11 ETO36768.1 - 0.079 13.2 0.0 0.18 12.0 0.0 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1768) DUF1918 PF08940.11 ETO36768.1 - 0.1 12.2 0.1 0.23 11.1 0.1 1.6 1 0 0 1 1 1 0 Domain of unknown function (DUF1918) Tn7_Tnp_TnsA_N PF08722.11 ETO36768.1 - 0.19 12.0 3.1 0.63 10.3 0.0 3.1 3 0 0 3 3 3 0 TnsA endonuclease N terminal Form_Nir_trans PF01226.17 ETO36769.1 - 0.12 11.8 1.1 0.16 11.3 1.1 1.2 1 0 0 1 1 1 0 Formate/nitrite transporter TPR_12 PF13424.6 ETO36770.1 - 1.1e-20 73.6 0.6 6.5e-11 42.4 0.0 2.4 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36770.1 - 7.6e-16 56.9 0.2 3.5e-05 23.5 0.0 4.5 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36770.1 - 8.2e-15 53.9 10.8 4.4e-06 26.3 0.3 4.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36770.1 - 4.1e-14 51.5 7.1 0.00072 19.5 0.0 4.5 4 0 0 4 4 4 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36770.1 - 6.9e-14 50.8 9.8 0.00072 19.6 0.4 4.7 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36770.1 - 9.6e-10 38.0 0.0 0.0034 17.2 0.0 4.6 4 0 0 4 4 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36770.1 - 2.3e-08 34.1 0.9 0.037 14.7 0.0 3.9 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36770.1 - 3.3e-06 26.7 6.2 0.21 11.3 0.3 4.8 4 1 0 4 4 4 2 TPR repeat MIT PF04212.18 ETO36770.1 - 0.001 19.1 7.8 0.039 14.0 0.1 4.4 4 0 0 4 4 4 1 MIT (microtubule interacting and transport) domain Cass2 PF14526.6 ETO36770.1 - 0.057 13.6 7.5 0.15 12.3 0.3 3.4 3 0 0 3 3 3 0 Integron-associated effector binding protein Peptidase_C14 PF00656.22 ETO36770.1 - 0.058 13.3 3.6 0.39 10.6 3.6 2.2 1 1 0 1 1 1 0 Caspase domain Sel1 PF08238.12 ETO36770.1 - 0.063 14.0 2.5 10 6.9 0.0 3.4 3 0 0 3 3 3 0 Sel1 repeat Kelch_6 PF13964.6 ETO36770.1 - 0.096 13.0 0.2 0.25 11.7 0.2 1.6 1 0 0 1 1 1 0 Kelch motif TPR_16 PF13432.6 ETO36770.1 - 0.12 13.0 0.0 38 5.0 0.0 3.1 3 0 0 3 3 3 0 Tetratricopeptide repeat Phage_tail_NK PF16532.5 ETO36771.1 - 0.031 13.9 0.0 0.046 13.3 0.0 1.3 1 0 0 1 1 1 0 Sf6-type phage tail needle knob or tip of some Caudovirales WD40 PF00400.32 ETO36772.1 - 8.4e-43 143.5 34.3 3.3e-07 30.9 0.1 8.0 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36772.1 - 1.3e-13 51.0 3.8 0.01 16.1 0.0 6.1 3 2 3 6 6 6 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36772.1 - 9.8e-10 37.7 10.9 0.0073 15.0 0.1 5.8 1 1 3 4 4 4 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36772.1 - 1.5e-07 31.1 7.2 0.0054 16.1 1.0 4.0 2 2 2 4 4 4 4 WD40-like domain U-box PF04564.15 ETO36773.1 - 1.4e-12 47.6 0.0 9.5e-12 44.9 0.0 1.9 1 1 0 1 1 1 1 U-box domain zf-NOSIP PF15906.5 ETO36773.1 - 0.05 13.8 0.0 0.069 13.3 0.0 1.2 1 0 0 1 1 1 0 Zinc-finger of nitric oxide synthase-interacting protein Yop-YscD_ppl PF16693.5 ETO36776.1 - 0.056 12.9 0.5 0.068 12.6 0.4 1.2 1 1 0 1 1 1 0 Inner membrane component of T3SS, periplasmic domain Sortase PF04203.13 ETO36776.1 - 0.14 11.9 0.7 12 5.8 0.3 2.0 1 1 1 2 2 2 0 Sortase domain DUF2208 PF09973.9 ETO36777.1 - 0.037 13.7 1.3 0.054 13.1 1.3 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2208) WD40 PF00400.32 ETO36779.1 - 1.6e-44 149.0 22.0 4.5e-06 27.3 0.2 8.0 7 2 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36779.1 - 8e-13 48.5 2.3 0.049 13.9 0.0 6.3 6 1 1 7 7 7 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36779.1 - 1.4e-11 43.7 3.1 0.026 13.2 0.1 5.6 2 1 3 5 5 5 5 Nucleoporin Nup120/160 Nucleoporin_N PF08801.11 ETO36779.1 - 0.00051 18.9 6.0 0.92 8.2 0.1 3.9 1 1 2 4 4 4 3 Nup133 N terminal like TPR_12 PF13424.6 ETO36780.1 - 1.7e-40 137.1 2.3 2.7e-13 50.0 0.0 3.6 2 1 0 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36780.1 - 1.5e-26 91.5 1.4 3.7e-07 29.8 0.3 6.2 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36780.1 - 1.7e-26 90.9 22.4 3.2e-07 29.9 0.1 6.4 6 0 0 6 6 6 4 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36780.1 - 1.7e-22 77.7 16.5 6.5e-06 25.9 0.1 5.7 6 0 0 6 6 5 4 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36780.1 - 9.8e-22 75.3 0.2 0.00011 21.9 0.0 5.3 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36780.1 - 2.1e-20 71.2 18.8 8.3e-05 22.5 0.4 5.7 5 0 0 5 5 5 4 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36780.1 - 1.2e-08 34.5 17.7 0.016 14.9 0.0 6.7 5 2 2 7 7 7 2 TPR repeat SNAP PF14938.6 ETO36780.1 - 7e-08 32.2 4.1 8.6e-06 25.4 1.1 2.3 2 0 0 2 2 2 2 Soluble NSF attachment protein, SNAP MIT PF04212.18 ETO36780.1 - 1.9e-06 27.9 11.3 0.027 14.6 0.1 5.1 5 0 0 5 5 5 1 MIT (microtubule interacting and transport) domain TPR_17 PF13431.6 ETO36780.1 - 5.8e-06 26.3 2.3 0.042 14.2 0.1 4.7 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36780.1 - 8.8e-06 26.0 0.5 7.3 7.5 0.0 4.8 5 0 0 5 5 4 1 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36780.1 - 6e-05 23.6 0.0 0.17 12.6 0.0 3.4 2 2 1 3 3 3 1 Tetratricopeptide repeat Tat PF00539.18 ETO36780.1 - 0.0011 19.1 0.3 0.84 9.8 0.0 4.2 4 0 0 4 4 4 1 Transactivating regulatory protein (Tat) TPR_14 PF13428.6 ETO36780.1 - 0.0011 19.6 0.0 14 6.9 0.0 4.0 4 0 0 4 4 4 0 Tetratricopeptide repeat DUF627 PF04781.12 ETO36780.1 - 0.013 15.6 0.1 0.64 10.1 0.0 2.7 2 0 0 2 2 2 0 Protein of unknown function (DUF627) TPR_MalT PF17874.1 ETO36780.1 - 0.023 14.1 0.0 0.055 12.8 0.0 1.6 1 0 0 1 1 1 0 MalT-like TPR region SHNi-TPR PF10516.9 ETO36780.1 - 0.044 13.2 0.6 1.3 8.5 0.0 3.1 3 0 0 3 3 3 0 SHNi-TPR TPR_19 PF14559.6 ETO36780.1 - 0.049 14.1 0.3 0.34 11.4 0.0 2.5 3 0 0 3 3 2 0 Tetratricopeptide repeat PPR PF01535.20 ETO36780.1 - 0.42 11.0 2.8 52 4.4 0.1 4.2 5 0 0 5 5 4 0 PPR repeat DUF5113 PF17140.4 ETO36780.1 - 1.3 8.8 14.5 9.9 5.9 0.8 4.8 4 2 1 5 5 5 0 Domain of unknown function (DUF5113) GUB_WAK_bind PF13947.6 ETO36780.1 - 1.6 9.5 6.8 8.4 7.2 0.1 3.8 4 0 0 4 4 4 0 Wall-associated receptor kinase galacturonan-binding TPR_12 PF13424.6 ETO36781.1 - 8e-28 96.6 1.0 4.8e-12 46.0 0.0 2.5 1 1 2 3 3 3 3 Tetratricopeptide repeat TPR_10 PF13374.6 ETO36781.1 - 9.5e-18 63.5 0.1 5e-09 35.7 0.0 3.6 4 0 0 4 4 4 3 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36781.1 - 5.1e-14 51.4 7.5 2.4e-07 30.3 0.5 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36781.1 - 2.1e-10 39.9 0.0 9.2e-05 22.2 0.0 2.6 2 0 0 2 2 2 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36781.1 - 1.3e-09 37.4 4.4 2.2e-05 24.2 0.2 3.4 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36781.1 - 7e-07 29.0 5.0 0.069 13.4 0.3 3.7 3 0 0 3 3 3 2 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36781.1 - 4.4e-05 23.1 7.7 0.3 10.8 0.1 4.4 3 1 1 4 4 4 3 TPR repeat TPR_MalT PF17874.1 ETO36781.1 - 0.00059 19.3 0.5 0.0012 18.3 0.5 1.5 1 0 0 1 1 1 1 MalT-like TPR region MIT PF04212.18 ETO36781.1 - 0.00081 19.4 1.6 0.44 10.6 0.0 3.5 3 0 0 3 3 3 1 MIT (microtubule interacting and transport) domain TPR_3 PF07720.12 ETO36781.1 - 0.015 15.3 1.1 0.49 10.4 0.1 2.6 2 0 0 2 2 2 0 Tetratricopeptide repeat TPR_14 PF13428.6 ETO36781.1 - 0.018 15.8 0.0 6.9 7.8 0.0 2.8 3 0 0 3 3 2 0 Tetratricopeptide repeat TPR_6 PF13174.6 ETO36781.1 - 0.021 15.4 0.1 9.7 7.1 0.0 2.7 2 0 0 2 2 2 0 Tetratricopeptide repeat DUF4404 PF14357.6 ETO36781.1 - 0.064 13.9 2.7 0.38 11.4 0.0 2.4 2 0 0 2 2 2 0 Domain of unknown function (DUF4404) KH_2 PF07650.17 ETO36782.1 - 0.019 14.8 0.0 0.042 13.7 0.0 1.5 1 0 0 1 1 1 0 KH domain SPRY PF00622.28 ETO36783.1 - 0.012 15.7 0.0 0.02 15.0 0.0 1.4 1 0 0 1 1 1 0 SPRY domain Kelch_2 PF07646.15 ETO36784.1 - 1.8e-07 30.8 4.2 0.11 12.5 0.1 5.1 5 0 0 5 5 5 3 Kelch motif Kelch_5 PF13854.6 ETO36784.1 - 4.9e-06 26.4 6.7 0.19 11.8 0.3 5.6 6 0 0 6 6 6 2 Kelch motif Kelch_6 PF13964.6 ETO36784.1 - 7.8e-05 22.8 2.5 10 6.6 0.1 4.5 3 1 1 4 4 4 2 Kelch motif Kelch_1 PF01344.25 ETO36784.1 - 0.00028 20.4 2.9 0.83 9.3 0.1 4.2 4 0 0 4 4 4 2 Kelch motif EHN PF06441.12 ETO36784.1 - 0.053 13.9 0.1 2.4 8.6 0.0 2.3 2 0 0 2 2 2 0 Epoxide hydrolase N terminus Kelch_4 PF13418.6 ETO36784.1 - 0.17 11.9 2.5 8.7 6.4 0.2 3.4 4 0 0 4 4 4 0 Galactose oxidase, central domain PUB PF09409.10 ETO36785.1 - 0.013 15.4 1.3 0.066 13.1 0.9 2.3 1 1 0 1 1 1 0 PUB domain IFT81_CH PF18383.1 ETO36785.1 - 0.028 14.7 4.4 0.39 11.0 0.1 2.9 2 1 1 3 3 3 0 Intraflagellar transport 81 calponin homology domain CUE PF02845.16 ETO36785.1 - 0.07 12.8 0.0 0.07 12.8 0.0 2.0 2 0 0 2 2 2 0 CUE domain DUF775 PF05603.12 ETO36786.1 - 0.54 9.8 7.8 0.086 12.4 2.2 2.2 1 1 1 2 2 2 0 Protein of unknown function (DUF775) Plasmid_RAQPRD PF09686.10 ETO36786.1 - 2.4 8.4 6.8 6.2 7.1 0.4 2.5 2 0 0 2 2 2 0 Plasmid protein of unknown function (Plasmid_RAQPRD) LIM PF00412.22 ETO36787.1 - 2.1e-08 34.2 5.6 2.1e-08 34.2 5.6 2.4 2 0 0 2 2 2 1 LIM domain DivIC PF04977.15 ETO36787.1 - 0.015 15.0 5.4 0.47 10.2 0.6 2.8 2 0 0 2 2 2 0 Septum formation initiator RILP PF11461.8 ETO36787.1 - 0.088 13.0 0.3 0.088 13.0 0.3 2.1 2 0 0 2 2 2 0 Rab interacting lysosomal protein bZIP_1 PF00170.21 ETO36787.1 - 0.77 9.9 3.4 11 6.2 0.1 2.6 2 0 0 2 2 2 0 bZIP transcription factor APC_N_CC PF16689.5 ETO36787.1 - 1.3 9.2 6.1 12 6.1 0.1 2.6 2 0 0 2 2 2 0 Coiled-coil N-terminus of APC, dimerisation domain zf-like PF04071.12 ETO36787.1 - 1.6 8.7 8.6 0.11 12.5 0.4 2.8 2 1 1 3 3 3 0 Cysteine-rich small domain C1_4 PF07975.12 ETO36787.1 - 7.3 6.9 9.3 3.1 8.1 2.1 3.3 3 0 0 3 3 3 0 TFIIH C1-like domain Rieske PF00355.26 ETO36788.1 - 5e-11 42.4 0.7 7.7e-11 41.8 0.7 1.5 1 1 0 1 1 1 1 Rieske [2Fe-2S] domain UCR_TM PF02921.14 ETO36788.1 - 0.00076 19.9 0.1 0.0026 18.2 0.0 1.9 2 0 0 2 2 2 1 Ubiquinol cytochrome reductase transmembrane region SMN PF06003.12 ETO36789.1 - 1.2e-08 34.6 13.4 1.1e-06 28.1 6.6 2.4 1 1 1 2 2 2 2 Survival motor neuron protein (SMN) CTNNB1_binding PF08347.11 ETO36789.1 - 0.0008 19.6 2.8 0.00096 19.4 2.8 1.1 1 0 0 1 1 1 1 N-terminal CTNNB1 binding V-ATPase_H_N PF03224.14 ETO36790.1 - 0.011 15.1 0.2 0.012 14.9 0.2 1.0 1 0 0 1 1 1 0 V-ATPase subunit H SmaI PF17411.2 ETO36790.1 - 0.06 12.5 0.0 0.063 12.4 0.0 1.1 1 0 0 1 1 1 0 Type II site-specific deoxyribonuclease FmiP_Thoc5 PF09766.9 ETO36791.1 - 0.022 14.1 0.1 0.023 14.0 0.1 1.1 1 0 0 1 1 1 0 Fms-interacting protein/Thoc5 HMA PF00403.26 ETO36791.1 - 0.084 13.3 0.1 0.12 12.8 0.1 1.3 1 0 0 1 1 1 0 Heavy-metal-associated domain Sulfatase PF00884.23 ETO36792.1 - 1.5e-33 116.5 0.0 1.8e-33 116.3 0.0 1.0 1 0 0 1 1 1 1 Sulfatase CAP_GLY PF01302.25 ETO36793.1 - 6.5e-34 115.8 4.7 1.9e-18 66.2 0.4 2.3 2 0 0 2 2 2 2 CAP-Gly domain Astro_capsid_p PF12226.8 ETO36793.1 - 2.2 7.4 15.6 3.2 6.8 15.6 1.2 1 0 0 1 1 1 0 Turkey astrovirus capsid protein DNA_pol_phi PF04931.13 ETO36793.1 - 3 5.9 18.3 4.9 5.1 18.3 1.4 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 ETO36793.1 - 3.2 7.1 24.2 17 4.7 23.2 1.9 1 1 1 2 2 2 0 SDA1 SAM_1 PF00536.30 ETO36794.1 - 1.8e-06 28.3 0.1 3.3e-06 27.4 0.1 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO36794.1 - 4.2e-05 23.6 0.0 7.3e-05 22.8 0.0 1.4 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) RasGEF PF00617.19 ETO36795.1 - 3.6e-52 177.1 1.9 1.2e-51 175.4 1.9 1.9 1 0 0 1 1 1 1 RasGEF domain RasGEF_N PF00618.20 ETO36795.1 - 7.7e-11 42.2 1.6 1.5e-10 41.2 0.1 2.3 2 1 0 2 2 2 1 RasGEF N-terminal motif DUF2935 PF11155.8 ETO36795.1 - 1.5 9.1 6.4 1.4 9.2 3.0 2.7 2 1 0 2 2 2 0 Domain of unknown function (DUF2935) ubiquitin PF00240.23 ETO36797.1 - 5.6e-07 29.2 1.8 7.4e-07 28.8 0.1 2.1 2 0 0 2 2 2 1 Ubiquitin family CAC1F_C PF16885.5 ETO36798.1 - 0.2 11.3 2.4 0.22 11.1 2.4 1.1 1 0 0 1 1 1 0 Voltage-gated calcium channel subunit alpha, C-term WD40 PF00400.32 ETO36799.1 - 0.00014 22.6 0.6 0.036 14.9 0.2 2.5 2 0 0 2 2 2 2 WD domain, G-beta repeat RNase_H PF00075.24 ETO36802.1 - 1.3e-07 31.8 0.0 1.9e-07 31.4 0.0 1.2 1 0 0 1 1 1 1 RNase H Aldo_ket_red PF00248.21 ETO36803.1 - 5.9e-52 176.7 0.1 5.3e-50 170.3 0.1 2.5 1 1 0 1 1 1 1 Aldo/keto reductase family DUF1203 PF06718.11 ETO36803.1 - 0.12 12.6 0.0 0.24 11.7 0.0 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF1203) MIEAP PF16026.5 ETO36804.1 - 7.6e-12 45.9 1.4 1.5e-11 44.9 1.4 1.4 1 0 0 1 1 1 1 Mitochondria-eating protein DUF445 PF04286.12 ETO36804.1 - 0.021 14.6 1.0 0.027 14.3 1.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF445) AnfG_VnfG PF03139.15 ETO36804.1 - 0.036 14.2 4.5 0.076 13.1 2.1 2.3 2 1 1 3 3 3 0 Vanadium/alternative nitrogenase delta subunit UQ_con PF00179.26 ETO36805.1 - 1.1e-19 70.5 0.0 1.6e-19 69.9 0.0 1.2 1 0 0 1 1 1 1 Ubiquitin-conjugating enzyme RWD PF05773.22 ETO36805.1 - 0.065 13.5 0.1 0.59 10.4 0.0 2.2 2 0 0 2 2 2 0 RWD domain DSBA PF01323.20 ETO36806.1 - 6e-34 117.5 0.0 7.6e-24 84.6 0.0 2.1 2 0 0 2 2 2 2 DSBA-like thioredoxin domain SGT1 PF07093.11 ETO36807.1 - 1.5e-47 162.4 49.9 6e-32 110.9 9.1 4.7 3 2 0 4 4 4 3 SGT1 protein zf-TRAF PF02176.18 ETO36808.1 - 3.8e-13 49.9 21.1 6e-08 33.3 4.5 6.3 3 1 2 5 5 5 3 TRAF-type zinc finger zf-C3HC4 PF00097.25 ETO36808.1 - 1.4e-08 34.4 14.5 1.4e-08 34.4 14.5 5.2 5 1 2 7 7 7 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_2 PF13923.6 ETO36808.1 - 4.1e-07 29.7 13.2 4.1e-07 29.7 13.2 4.9 4 0 0 4 4 4 1 Zinc finger, C3HC4 type (RING finger) zf-RING_2 PF13639.6 ETO36808.1 - 4.2e-07 30.2 13.4 4.2e-07 30.2 13.4 6.0 3 2 2 5 5 5 1 Ring finger domain Prok-RING_4 PF14447.6 ETO36808.1 - 3.4e-05 23.6 12.1 3.4e-05 23.6 12.1 5.4 5 1 0 5 5 5 1 Prokaryotic RING finger family 4 zf-RING_6 PF14835.6 ETO36808.1 - 4.2e-05 23.3 5.8 0.00018 21.3 5.8 2.1 1 0 0 1 1 1 1 zf-RING of BARD1-type protein zf-RING_UBOX PF13445.6 ETO36808.1 - 0.00013 21.9 11.2 0.00013 21.9 11.2 3.3 3 0 0 3 3 3 1 RING-type zinc-finger zf-RING_4 PF14570.6 ETO36808.1 - 0.015 15.1 9.3 0.015 15.1 9.3 5.5 5 1 1 6 6 6 0 RING/Ubox like zinc-binding domain zf-RING_5 PF14634.6 ETO36808.1 - 0.015 15.3 13.1 0.015 15.3 13.1 6.1 7 0 0 7 7 7 0 zinc-RING finger domain PhnA_Zn_Ribbon PF08274.12 ETO36808.1 - 1.9 8.5 16.0 1.8 8.6 2.3 3.8 3 0 0 3 3 3 0 PhnA Zinc-Ribbon DUF908 PF06012.12 ETO36809.1 - 0.2 11.0 7.6 0.25 10.7 7.6 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) DDHD PF02862.17 ETO36809.1 - 0.59 10.2 8.0 0.69 10.0 8.0 1.3 1 0 0 1 1 1 0 DDHD domain LAP1C PF05609.12 ETO36809.1 - 0.85 8.6 14.7 0.91 8.5 14.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) PGA2 PF07543.12 ETO36809.1 - 1.6 8.7 16.6 2.4 8.2 16.6 1.3 1 0 0 1 1 1 0 Protein trafficking PGA2 CDC45 PF02724.14 ETO36809.1 - 1.7 6.8 14.6 1.8 6.7 14.6 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO36809.1 - 2.2 6.9 14.9 2.5 6.7 14.9 1.1 1 0 0 1 1 1 0 Presenilin Vfa1 PF08432.10 ETO36809.1 - 2.2 8.6 16.9 3.2 8.0 16.9 1.3 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 Peptidase_S64 PF08192.11 ETO36809.1 - 2.7 6.4 16.3 2.7 6.4 16.3 1.1 1 0 0 1 1 1 0 Peptidase family S64 GREB1 PF15782.5 ETO36809.1 - 2.7 5.0 9.0 2.4 5.2 9.0 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer CSRNP_N PF16019.5 ETO36809.1 - 4 7.3 10.5 6.5 6.6 10.5 1.5 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus DUF4407 PF14362.6 ETO36809.1 - 4.4 6.6 6.2 4.7 6.5 6.2 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Zip PF02535.22 ETO36809.1 - 4.7 6.3 7.5 4.2 6.5 7.5 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter Band_3_cyto PF07565.13 ETO36809.1 - 4.8 6.9 11.8 6.2 6.5 11.8 1.2 1 0 0 1 1 1 0 Band 3 cytoplasmic domain SLC12 PF03522.15 ETO36809.1 - 7.3 5.5 15.6 9 5.2 15.6 1.1 1 0 0 1 1 1 0 Solute carrier family 12 EF-hand_7 PF13499.6 ETO36810.1 - 5.4e-06 26.8 1.2 1.9e-05 25.0 1.2 2.0 1 0 0 1 1 1 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO36810.1 - 3.5e-05 23.4 11.0 0.00066 19.4 0.4 3.5 3 0 0 3 3 3 2 EF-hand domain EF-hand_1 PF00036.32 ETO36810.1 - 5.6e-05 22.4 4.1 0.0026 17.2 0.8 3.5 4 0 0 4 4 4 2 EF hand EF-hand_14 PF17959.1 ETO36810.1 - 0.00036 20.8 0.4 0.0043 17.4 0.2 2.4 2 0 0 2 2 2 1 EF-hand domain EF-hand_8 PF13833.6 ETO36810.1 - 0.00055 19.7 4.4 0.0013 18.5 0.2 2.7 1 1 1 2 2 2 2 EF-hand domain pair EF-hand_5 PF13202.6 ETO36810.1 - 0.039 13.5 4.8 0.11 12.1 0.3 3.3 3 0 0 3 3 3 0 EF hand SAP PF02037.27 ETO36812.1 - 5e-07 29.3 0.9 7.2e-07 28.8 0.2 1.7 2 0 0 2 2 2 1 SAP domain DNA_gyraseB PF00204.25 ETO36812.1 - 0.0065 16.0 1.0 0.025 14.1 0.2 2.2 1 1 2 3 3 3 1 DNA gyrase B PADR1 PF08063.12 ETO36812.1 - 0.0086 15.8 2.4 0.0086 15.8 2.4 2.2 2 1 0 2 2 2 1 PADR1 (NUC008) domain THF_DHG_CYH PF00763.23 ETO36812.1 - 0.027 14.7 0.6 0.05 13.9 0.1 1.8 2 0 0 2 2 2 0 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain Telomere_Sde2_2 PF13297.6 ETO36812.1 - 0.11 12.2 0.1 0.2 11.3 0.1 1.4 1 0 0 1 1 1 0 Telomere stability C-terminal TcdB_N PF12918.7 ETO36812.1 - 0.48 10.7 5.3 2.9 8.2 0.2 2.5 2 0 0 2 2 2 0 TcdB toxin N-terminal helical domain DUF2703 PF10865.8 ETO36812.1 - 1.9 8.7 5.0 1.3 9.2 0.1 2.4 2 1 0 2 2 2 0 Domain of unknown function (DUF2703) RVT_1 PF00078.27 ETO36813.1 - 1.5e-07 31.2 0.0 2e-07 30.8 0.0 1.2 1 0 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) CENP-R PF06729.12 ETO36813.1 - 2.2 8.2 6.5 4.3 7.3 0.1 2.4 2 1 0 2 2 2 0 Kinetochore component, CENP-R Cwf_Cwc_15 PF04889.12 ETO36814.1 - 0.037 13.8 4.5 0.11 12.2 4.5 1.7 1 1 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein WD40 PF00400.32 ETO36817.1 - 0.0029 18.4 1.2 0.01 16.7 0.5 2.3 2 2 0 2 2 2 1 WD domain, G-beta repeat Beta_helix PF13229.6 ETO36817.1 - 0.041 13.7 2.3 0.052 13.4 2.3 1.2 1 0 0 1 1 1 0 Right handed beta helix region UPF0180 PF03698.13 ETO36818.1 - 0.028 14.6 0.1 0.06 13.5 0.1 1.6 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0180) HGTP_anticodon PF03129.20 ETO36818.1 - 0.05 13.7 0.3 0.072 13.2 0.3 1.3 1 0 0 1 1 1 0 Anticodon binding domain RNase_H PF00075.24 ETO36819.1 - 3.3e-07 30.6 0.0 0.0038 17.4 0.0 2.1 1 1 1 2 2 2 2 RNase H DUF4616 PF15394.6 ETO36822.1 - 0.0064 15.5 8.4 0.0071 15.4 8.4 1.0 1 0 0 1 1 1 1 Domain of unknown function (DUF4616) Dynactin_p62 PF05502.13 ETO36822.1 - 0.08 11.7 14.9 0.091 11.5 14.9 1.0 1 0 0 1 1 1 0 Dynactin p62 family COG4 PF08318.12 ETO36822.1 - 0.17 10.9 7.7 0.18 10.9 7.7 1.1 1 0 0 1 1 1 0 COG4 transport protein XRN_M PF17846.1 ETO36822.1 - 4.4 6.2 15.6 5 6.0 15.6 1.0 1 0 0 1 1 1 0 Xrn1 helical domain WDCP PF15390.6 ETO36822.1 - 8.8 4.6 11.7 9.4 4.5 11.7 1.0 1 0 0 1 1 1 0 WD repeat and coiled-coil-containing protein family Pkinase PF00069.25 ETO36824.1 - 1.8e-06 27.5 0.2 1.8e-06 27.5 0.2 2.0 2 0 0 2 2 2 1 Protein kinase domain NMDAR2_C PF10565.9 ETO36824.1 - 0.0039 16.1 8.0 0.0048 15.8 8.0 1.0 1 0 0 1 1 1 1 N-methyl D-aspartate receptor 2B3 C-terminus Pkinase_Tyr PF07714.17 ETO36824.1 - 0.0083 15.4 0.1 0.0083 15.4 0.1 1.7 2 0 0 2 2 2 1 Protein tyrosine kinase ABC1 PF03109.16 ETO36824.1 - 0.024 14.8 0.9 0.043 14.0 0.1 1.7 2 0 0 2 2 2 0 ABC1 family DUF2072 PF09845.9 ETO36824.1 - 0.039 14.2 5.4 0.052 13.8 5.4 1.3 1 0 0 1 1 1 0 Zn-ribbon containing protein Spt20 PF12090.8 ETO36824.1 - 0.18 11.4 20.7 0.2 11.3 20.7 1.1 1 0 0 1 1 1 0 Spt20 family DUF1501 PF07394.12 ETO36824.1 - 0.21 10.6 5.1 0.22 10.6 5.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF1501) Neur_chan_memb PF02932.16 ETO36824.1 - 0.87 9.6 9.6 0.98 9.4 9.6 1.0 1 0 0 1 1 1 0 Neurotransmitter-gated ion-channel transmembrane region FAM60A PF15396.6 ETO36824.1 - 0.89 9.5 10.0 1.1 9.2 10.0 1.1 1 0 0 1 1 1 0 Protein Family FAM60A Presenilin PF01080.17 ETO36824.1 - 1 8.1 15.5 1 8.1 15.5 1.0 1 0 0 1 1 1 0 Presenilin RP-C_C PF11800.8 ETO36824.1 - 1 9.4 9.4 1.3 9.1 9.4 1.2 1 0 0 1 1 1 0 Replication protein C C-terminal region NST1 PF13945.6 ETO36824.1 - 1.3 9.1 18.8 1.5 8.9 18.8 1.2 1 0 0 1 1 1 0 Salt tolerance down-regulator NPR3 PF03666.13 ETO36824.1 - 1.6 7.4 14.0 1.7 7.4 14.0 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Tim54 PF11711.8 ETO36824.1 - 1.9 7.2 10.4 2 7.1 10.4 1.1 1 0 0 1 1 1 0 Inner membrane protein import complex subunit Tim54 ALMT PF11744.8 ETO36824.1 - 3.6 6.3 10.3 4.1 6.1 10.3 1.1 1 0 0 1 1 1 0 Aluminium activated malate transporter DDHD PF02862.17 ETO36824.1 - 3.9 7.6 11.2 4.3 7.4 11.2 1.2 1 0 0 1 1 1 0 DDHD domain DAG_kinase_N PF14513.6 ETO36824.1 - 4 7.6 10.8 4.8 7.4 10.8 1.3 1 0 0 1 1 1 0 Diacylglycerol kinase N-terminus CCDC53 PF10152.9 ETO36824.1 - 4.1 7.8 16.7 7.2 7.0 16.7 1.5 1 1 0 1 1 1 0 Subunit CCDC53 of WASH complex Zip PF02535.22 ETO36824.1 - 4.3 6.4 8.6 4.3 6.4 8.6 1.1 1 0 0 1 1 1 0 ZIP Zinc transporter SLC12 PF03522.15 ETO36824.1 - 5.2 6.0 14.8 5.9 5.8 14.8 1.0 1 0 0 1 1 1 0 Solute carrier family 12 Dicty_REP PF05086.12 ETO36824.1 - 6.3 4.6 17.0 6.4 4.6 17.0 1.0 1 0 0 1 1 1 0 Dictyostelium (Slime Mold) REP protein DUF4407 PF14362.6 ETO36824.1 - 7.1 5.9 8.4 7.2 5.9 8.4 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) GREB1 PF15782.5 ETO36824.1 - 7.2 3.6 13.3 7.8 3.5 13.3 1.0 1 0 0 1 1 1 0 Gene regulated by oestrogen in breast cancer Sec62 PF03839.16 ETO36824.1 - 8.1 5.9 10.0 8.5 5.8 10.0 1.2 1 0 0 1 1 1 0 Translocation protein Sec62 Band_3_cyto PF07565.13 ETO36824.1 - 8.3 6.1 8.2 8.4 6.1 8.2 1.1 1 0 0 1 1 1 0 Band 3 cytoplasmic domain DUF2052 PF09747.9 ETO36825.1 - 9.8e-06 25.8 9.2 3.3e-05 24.1 9.2 1.7 1 1 0 1 1 1 1 Coiled-coil domain containing protein (DUF2052) GAGA_bind PF06217.12 ETO36825.1 - 0.0002 21.8 4.7 0.00025 21.4 4.7 1.1 1 0 0 1 1 1 1 GAGA binding protein-like family BUD22 PF09073.10 ETO36825.1 - 0.00024 20.6 9.6 0.00027 20.4 9.6 1.1 1 0 0 1 1 1 1 BUD22 Astro_capsid_p PF12226.8 ETO36825.1 - 0.0067 15.6 7.0 0.0089 15.2 7.0 1.1 1 0 0 1 1 1 1 Turkey astrovirus capsid protein ASC PF00858.24 ETO36825.1 - 0.084 11.8 2.1 0.094 11.7 2.1 1.1 1 0 0 1 1 1 0 Amiloride-sensitive sodium channel Tom22 PF04281.13 ETO36825.1 - 0.094 12.5 6.9 0.16 11.7 6.9 1.4 1 0 0 1 1 1 0 Mitochondrial import receptor subunit Tom22 V_ATPase_I PF01496.19 ETO36825.1 - 0.17 9.7 6.5 0.22 9.4 6.5 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family OATP PF03137.20 ETO36825.1 - 0.18 10.0 1.1 0.31 9.3 1.1 1.3 1 0 0 1 1 1 0 Organic Anion Transporter Polypeptide (OATP) family Zip PF02535.22 ETO36825.1 - 0.2 10.9 4.6 0.24 10.6 4.6 1.2 1 0 0 1 1 1 0 ZIP Zinc transporter FAM60A PF15396.6 ETO36825.1 - 0.29 11.1 6.0 0.35 10.8 6.0 1.2 1 0 0 1 1 1 0 Protein Family FAM60A CDC45 PF02724.14 ETO36825.1 - 0.39 9.0 9.5 0.46 8.7 9.5 1.1 1 0 0 1 1 1 0 CDC45-like protein Presenilin PF01080.17 ETO36825.1 - 0.59 8.8 8.4 0.74 8.5 8.4 1.1 1 0 0 1 1 1 0 Presenilin NPR3 PF03666.13 ETO36825.1 - 1.2 7.8 11.5 1.5 7.6 11.5 1.1 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 Vfa1 PF08432.10 ETO36825.1 - 1.3 9.4 18.5 1.9 8.8 18.5 1.2 1 0 0 1 1 1 0 AAA-ATPase Vps4-associated protein 1 CSRNP_N PF16019.5 ETO36825.1 - 2 8.3 7.7 2.9 7.8 7.7 1.2 1 0 0 1 1 1 0 Cysteine/serine-rich nuclear protein N-terminus PPL5 PF18168.1 ETO36825.1 - 2.3 7.4 8.4 3.2 7.0 8.4 1.2 1 0 0 1 1 1 0 Prim-pol family 5 DUF4746 PF15928.5 ETO36825.1 - 4.4 6.6 14.5 6.2 6.1 14.5 1.1 1 0 0 1 1 1 0 Domain of unknown function (DUF4746) DUF2076 PF09849.9 ETO36825.1 - 4.6 7.2 14.3 0.24 11.4 8.3 1.8 2 0 0 2 2 2 0 Uncharacterized protein conserved in bacteria (DUF2076) NOA36 PF06524.12 ETO36825.1 - 8 5.7 16.3 11 5.3 16.3 1.1 1 0 0 1 1 1 0 NOA36 protein Big_6 PF17936.1 ETO36826.1 - 0.27 11.5 1.4 23 5.3 0.2 2.3 2 0 0 2 2 2 0 Bacterial Ig domain FtsH_ext PF06480.15 ETO36826.1 - 0.41 11.0 2.1 2.9 8.3 2.1 2.2 1 1 0 1 1 1 0 FtsH Extracellular ERp29 PF07749.12 ETO36827.1 - 0.044 14.7 0.3 0.05 14.5 0.3 1.2 1 0 0 1 1 1 0 Endoplasmic reticulum protein ERp29, C-terminal domain A2M PF00207.22 ETO36828.1 - 0.13 12.1 0.4 5.1 7.0 0.0 2.2 1 1 1 2 2 2 0 Alpha-2-macroglobulin family NUDIX_4 PF14815.6 ETO36830.1 - 0.058 13.4 0.0 0.36 10.8 0.0 2.1 2 0 0 2 2 2 0 NUDIX domain LigT_PEase PF02834.16 ETO36830.1 - 0.15 12.2 0.1 1.4 9.1 0.0 2.4 2 0 0 2 2 2 0 LigT like Phosphoesterase GIT_CC PF16559.5 ETO36830.1 - 0.24 11.3 2.8 3.2 7.7 0.6 2.8 1 1 1 2 2 2 0 GIT coiled-coil Rho guanine nucleotide exchange factor CENP-H PF05837.12 ETO36830.1 - 0.56 10.6 3.4 1.5 9.2 3.4 1.8 1 1 0 1 1 1 0 Centromere protein H (CENP-H) TPR_MLP1_2 PF07926.12 ETO36831.1 - 0.024 14.7 1.8 0.024 14.7 1.8 6.3 5 2 0 6 6 6 0 TPR/MLP1/MLP2-like protein TMF_DNA_bd PF12329.8 ETO36832.1 - 0.0031 17.5 8.9 0.0031 17.5 8.9 2.6 1 1 1 2 2 2 1 TATA element modulatory factor 1 DNA binding BLOC1_2 PF10046.9 ETO36832.1 - 0.006 16.9 13.7 0.32 11.3 4.1 2.3 1 1 1 2 2 2 2 Biogenesis of lysosome-related organelles complex-1 subunit 2 Nup54 PF13874.6 ETO36832.1 - 0.013 15.6 10.4 0.11 12.7 10.4 2.0 1 1 0 1 1 1 0 Nucleoporin complex subunit 54 B3_4 PF03483.17 ETO36832.1 - 0.02 14.6 0.2 0.031 14.0 0.2 1.3 1 0 0 1 1 1 0 B3/4 domain GAS PF13851.6 ETO36832.1 - 0.12 11.7 20.2 0.31 10.4 4.6 2.7 2 1 1 3 3 3 0 Growth-arrest specific micro-tubule binding DUF948 PF06103.11 ETO36832.1 - 0.13 12.6 2.0 0.24 11.7 2.0 1.5 1 0 0 1 1 1 0 Bacterial protein of unknown function (DUF948) ATG16 PF08614.11 ETO36832.1 - 0.16 12.2 18.1 0.21 11.8 18.1 1.1 1 0 0 1 1 1 0 Autophagy protein 16 (ATG16) DUF4407 PF14362.6 ETO36832.1 - 0.19 11.0 9.4 0.26 10.6 9.4 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4407) Cadherin_tail PF15974.5 ETO36832.1 - 0.21 11.9 1.9 0.41 11.0 1.9 1.5 1 0 0 1 1 1 0 Cadherin C-terminal cytoplasmic tail, catenin-binding region KxDL PF10241.9 ETO36832.1 - 0.23 11.8 7.8 0.58 10.5 7.0 2.2 1 1 1 2 2 2 0 Uncharacterized conserved protein UPF0242 PF06785.11 ETO36832.1 - 0.23 11.5 16.6 0.31 11.1 16.6 1.2 1 0 0 1 1 1 0 Uncharacterised protein family (UPF0242) N-terminus V_ATPase_I PF01496.19 ETO36832.1 - 0.42 8.5 11.1 0.51 8.2 11.1 1.1 1 0 0 1 1 1 0 V-type ATPase 116kDa subunit family Lectin_N PF03954.14 ETO36832.1 - 0.57 9.9 10.3 0.049 13.4 2.8 2.2 1 1 1 2 2 2 0 Hepatic lectin, N-terminal domain DHR10 PF18595.1 ETO36832.1 - 0.8 9.8 19.7 2.8 8.0 4.5 2.4 1 1 1 2 2 2 0 Designed helical repeat protein 10 domain Jnk-SapK_ap_N PF09744.9 ETO36832.1 - 1.3 9.2 19.4 0.32 11.2 9.7 2.2 1 1 1 2 2 2 0 JNK_SAPK-associated protein-1 DUF4472 PF14739.6 ETO36832.1 - 1.4 9.7 17.4 0.39 11.5 8.1 2.6 1 1 2 3 3 3 0 Domain of unknown function (DUF4472) DivIC PF04977.15 ETO36832.1 - 2.2 8.1 12.3 0.57 10.0 1.4 2.7 2 1 0 2 2 2 0 Septum formation initiator Atg14 PF10186.9 ETO36832.1 - 2.8 6.9 13.1 3.5 6.6 13.1 1.2 1 0 0 1 1 1 0 Vacuolar sorting 38 and autophagy-related subunit 14 APG6_N PF17675.1 ETO36832.1 - 4 8.0 24.5 1.7 9.2 9.2 2.4 1 1 1 2 2 2 0 Apg6 coiled-coil region SlyX PF04102.12 ETO36832.1 - 5.1 7.8 7.5 16 6.2 0.1 2.5 1 1 0 2 2 2 0 SlyX Pkinase PF00069.25 ETO36833.1 - 8.6e-66 222.0 0.7 8.6e-65 218.7 0.7 2.1 1 1 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36833.1 - 1.1e-34 119.9 1.3 1.3e-34 119.7 0.2 1.5 2 0 0 2 2 2 1 Protein tyrosine kinase Kinase-like PF14531.6 ETO36833.1 - 0.00017 21.0 0.0 0.00028 20.3 0.0 1.5 1 0 0 1 1 1 1 Kinase-like Kdo PF06293.14 ETO36833.1 - 0.013 14.8 0.1 0.013 14.8 0.1 1.8 2 0 0 2 2 2 0 Lipopolysaccharide kinase (Kdo/WaaP) family PH PF00169.29 ETO36833.1 - 0.02 15.4 0.2 0.02 15.4 0.2 2.7 3 1 0 3 3 3 0 PH domain DUF5128 PF17170.4 ETO36833.1 - 0.02 14.0 0.2 0.02 14.0 0.2 2.7 2 1 1 3 3 3 0 6-bladed beta-propeller PhyH PF05721.13 ETO36834.1 - 4.6e-10 40.1 0.0 7.7e-10 39.4 0.0 1.5 1 0 0 1 1 1 1 Phytanoyl-CoA dioxygenase (PhyH) Borrelia_lipo_1 PF05714.11 ETO36834.1 - 0.0045 16.8 3.3 0.0082 15.9 3.3 1.3 1 0 0 1 1 1 1 Borrelia burgdorferi virulent strain associated lipoprotein Hydrolase_6 PF13344.6 ETO36834.1 - 0.069 13.3 0.0 0.15 12.2 0.0 1.6 1 0 0 1 1 1 0 Haloacid dehalogenase-like hydrolase AA_permease PF00324.21 ETO36835.1 - 2.5e-15 56.1 9.4 3.3e-15 55.7 9.4 1.1 1 0 0 1 1 1 1 Amino acid permease AA_permease_2 PF13520.6 ETO36835.1 - 2.4e-06 26.6 9.2 3.3e-06 26.2 9.2 1.1 1 0 0 1 1 1 1 Amino acid permease Laminin_G_3 PF13385.6 ETO36837.1 - 3.8e-08 33.6 0.0 6.2e-06 26.4 0.0 2.8 1 1 0 1 1 1 1 Concanavalin A-like lectin/glucanases superfamily Phosphodiest PF01663.22 ETO36838.1 - 7.5e-33 114.6 0.3 9.9e-33 114.2 0.3 1.0 1 0 0 1 1 1 1 Type I phosphodiesterase / nucleotide pyrophosphatase Metalloenzyme PF01676.18 ETO36838.1 - 0.00028 20.4 0.0 0.00037 19.9 0.0 1.1 1 0 0 1 1 1 1 Metalloenzyme superfamily Sulfatase PF00884.23 ETO36838.1 - 0.017 14.5 0.2 0.032 13.6 0.2 1.5 1 1 0 1 1 1 0 Sulfatase DUF229 PF02995.17 ETO36838.1 - 0.11 11.0 0.0 0.14 10.7 0.0 1.1 1 0 0 1 1 1 0 Protein of unknown function (DUF229) GILT PF03227.16 ETO36840.1 - 6.9e-21 74.5 0.7 1.3e-20 73.6 0.7 1.5 1 0 0 1 1 1 1 Gamma interferon inducible lysosomal thiol reductase (GILT) Pkinase PF00069.25 ETO36841.1 - 1.5e-10 40.9 0.0 2.5e-10 40.2 0.0 1.2 1 0 0 1 1 1 1 Protein kinase domain PPR_3 PF13812.6 ETO36842.1 - 0.0001 22.3 0.4 0.00021 21.3 0.4 1.5 1 0 0 1 1 1 1 Pentatricopeptide repeat domain CheR PF01739.18 ETO36842.1 - 0.035 13.6 0.4 0.04 13.4 0.4 1.2 1 0 0 1 1 1 0 CheR methyltransferase, SAM binding domain TPR_8 PF13181.6 ETO36842.1 - 0.099 12.9 0.0 0.19 12.0 0.0 1.5 1 0 0 1 1 1 0 Tetratricopeptide repeat Phage_capsid PF05065.13 ETO36843.1 - 0.1 11.9 0.0 0.12 11.7 0.0 1.1 1 0 0 1 1 1 0 Phage capsid family zf-C2HE PF16278.5 ETO36844.1 - 0.24 11.9 0.2 0.24 11.9 0.2 2.2 2 0 0 2 2 2 0 C2HE / C2H2 / C2HC zinc-binding finger Cys_Met_Meta_PP PF01053.20 ETO36845.1 - 5.9e-146 485.9 0.0 6.8e-146 485.7 0.0 1.0 1 0 0 1 1 1 1 Cys/Met metabolism PLP-dependent enzyme Aminotran_1_2 PF00155.21 ETO36845.1 - 5.7e-09 35.6 0.0 8.3e-09 35.1 0.0 1.2 1 0 0 1 1 1 1 Aminotransferase class I and II Aminotran_5 PF00266.19 ETO36845.1 - 9.1e-08 31.4 0.0 1.7e-06 27.3 0.0 2.0 2 0 0 2 2 2 1 Aminotransferase class-V MHB PF16525.5 ETO36845.1 - 0.15 12.3 0.1 3.3 8.0 0.0 2.5 2 0 0 2 2 2 0 Haemophore, haem-binding HMG_box PF00505.19 ETO36846.1 - 0.0019 18.6 5.2 0.0019 18.6 5.2 2.7 2 1 1 3 3 3 1 HMG (high mobility group) box RasGEF_N PF00618.20 ETO36847.1 - 0.074 13.3 2.7 0.17 12.2 2.8 1.6 1 1 1 2 2 2 0 RasGEF N-terminal motif Tubulin PF00091.25 ETO36848.1 - 8e-33 114.3 0.1 1e-32 114.0 0.1 1.0 1 0 0 1 1 1 1 Tubulin/FtsZ family, GTPase domain PCRF PF03462.18 ETO36848.1 - 0.04 13.8 0.0 0.056 13.3 0.0 1.2 1 0 0 1 1 1 0 PCRF domain Lsm_C PF14894.6 ETO36848.1 - 0.091 12.6 0.2 0.31 10.8 0.0 2.0 2 0 0 2 2 2 0 Lsm C-terminal BBE PF08031.12 ETO36849.1 - 0.17 12.0 1.1 0.29 11.3 1.1 1.4 1 0 0 1 1 1 0 Berberine and berberine like WD40 PF00400.32 ETO36851.1 - 2.5e-16 59.7 1.9 3.7e-07 30.7 0.0 4.1 3 1 0 3 3 3 3 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36851.1 - 4.4e-05 23.7 0.0 0.013 15.8 0.0 2.4 1 1 1 2 2 2 2 Anaphase-promoting complex subunit 4 WD40 domain SMC_ScpA PF02616.14 ETO36851.1 - 0.12 12.3 0.4 0.18 11.7 0.4 1.2 1 0 0 1 1 1 0 Segregation and condensation protein ScpA SH3_13 PF18335.1 ETO36851.1 - 9.7 6.1 10.9 2.3 8.1 0.1 3.3 2 1 1 3 3 3 0 ATP-dependent RecD-like DNA helicase SH3 domain WD40 PF00400.32 ETO36852.1 - 4.3e-36 122.3 4.4 5.6e-06 27.0 0.4 6.2 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36852.1 - 1.9e-16 60.1 0.2 0.0024 18.1 0.1 5.1 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO36852.1 - 2.2e-08 34.2 0.0 0.0032 17.4 0.0 2.5 1 1 1 2 2 2 2 Eukaryotic translation initiation factor eIF2A Ge1_WD40 PF16529.5 ETO36852.1 - 1.1e-07 31.1 0.0 0.1 11.5 0.0 3.7 1 1 4 5 5 5 3 WD40 region of Ge1, enhancer of mRNA-decapping protein Nup160 PF11715.8 ETO36852.1 - 1.7e-06 27.0 0.0 0.037 12.7 0.0 4.3 1 1 4 5 5 5 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36852.1 - 7e-05 22.3 0.3 0.034 13.5 0.1 2.7 1 1 2 3 3 3 2 WD40-like domain ROS_MUCR PF05443.11 ETO36852.1 - 0.00063 19.8 0.1 8.9 6.4 0.0 4.0 2 1 1 3 3 3 1 ROS/MUCR transcriptional regulator protein PD40 PF07676.12 ETO36852.1 - 0.0017 18.3 0.4 28 4.8 0.0 5.0 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nucleoporin_N PF08801.11 ETO36852.1 - 0.0048 15.7 1.1 0.052 12.3 1.3 1.9 1 1 1 2 2 2 1 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO36852.1 - 0.0077 14.8 0.0 0.76 8.2 0.0 2.7 1 1 2 3 3 3 1 Cytochrome D1 heme domain PALB2_WD40 PF16756.5 ETO36852.1 - 0.025 13.5 0.3 0.36 9.7 0.1 2.4 1 1 1 3 3 3 0 Partner and localizer of BRCA2 WD40 domain DUF5122 PF17164.4 ETO36852.1 - 0.031 14.6 0.5 50 4.3 0.1 3.8 5 0 0 5 5 4 0 Domain of unknown function (DUF5122) beta-propeller Nbas_N PF15492.6 ETO36852.1 - 0.071 12.4 0.2 9.1 5.5 0.1 2.8 1 1 1 2 2 2 0 Neuroblastoma-amplified sequence, N terminal Proteasome_A_N PF10584.9 ETO36852.1 - 3.6 7.3 4.1 35 4.2 0.0 3.5 4 0 0 4 4 4 0 Proteasome subunit A N-terminal signature WD40 PF00400.32 ETO36855.1 - 1.5e-09 38.3 5.5 0.00079 20.2 1.0 3.8 3 1 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO36855.1 - 0.0017 17.1 0.1 1.1 7.9 0.0 2.1 2 0 0 2 2 2 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36855.1 - 0.0082 16.4 0.1 0.33 11.3 0.0 2.2 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain Zea_mays_MuDR PF05928.11 ETO36855.1 - 0.064 12.9 0.1 0.079 12.6 0.1 1.1 1 0 0 1 1 1 0 Zea mays MURB-like protein (MuDR) DUF4979 PF16351.5 ETO36855.1 - 0.25 11.6 2.0 29 4.9 0.1 3.0 2 1 1 3 3 3 0 Domain of unknown function (DUF4979) WD40 PF00400.32 ETO36856.1 - 9.8e-57 187.6 21.7 6.2e-11 42.7 0.1 7.1 7 0 0 7 7 7 7 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36856.1 - 4.4e-18 65.4 4.7 0.013 15.8 0.0 7.0 2 1 6 8 8 8 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36856.1 - 1.9e-13 50.1 0.1 0.0063 15.5 0.0 5.2 1 1 3 5 5 5 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36856.1 - 3.7e-06 26.5 0.6 0.78 9.0 0.0 3.6 2 2 0 3 3 3 2 WD40-like domain Nup160 PF11715.8 ETO36856.1 - 2.7e-05 23.1 2.6 1.6 7.3 0.0 4.6 2 1 3 5 5 5 3 Nucleoporin Nup120/160 Nbas_N PF15492.6 ETO36856.1 - 3e-05 23.5 3.2 0.85 8.9 0.1 4.4 1 1 4 5 5 5 1 Neuroblastoma-amplified sequence, N terminal Cytochrom_D1 PF02239.16 ETO36856.1 - 9.6e-05 21.1 1.5 0.067 11.7 0.1 3.4 2 1 2 4 4 4 3 Cytochrome D1 heme domain PD40 PF07676.12 ETO36856.1 - 0.0002 21.2 7.2 2 8.5 0.1 4.5 4 0 0 4 4 4 2 WD40-like Beta Propeller Repeat PQQ PF01011.21 ETO36856.1 - 0.00045 20.0 0.0 20 5.4 0.0 5.0 5 0 0 5 5 5 0 PQQ enzyme repeat PQQ_2 PF13360.6 ETO36856.1 - 0.0015 18.1 0.2 0.011 15.3 0.2 2.2 1 1 0 1 1 1 1 PQQ-like domain Nucleoporin_N PF08801.11 ETO36856.1 - 0.0035 16.1 4.4 0.31 9.7 0.1 3.4 1 1 1 3 3 3 2 Nup133 N terminal like Ricin_B_lectin PF00652.22 ETO36856.1 - 0.0088 16.3 0.3 0.13 12.5 0.1 2.5 2 1 0 2 2 2 1 Ricin-type beta-trefoil lectin domain DUF5046 PF16465.5 ETO36856.1 - 0.013 15.0 0.0 0.76 9.2 0.0 2.8 1 1 2 3 3 3 0 Domain of unknown function (DUF5046) Me-amine-dh_H PF06433.11 ETO36856.1 - 0.093 11.6 0.0 3.7 6.3 0.0 2.5 1 1 0 2 2 2 0 Methylamine dehydrogenase heavy chain (MADH) VID27 PF08553.10 ETO36856.1 - 0.11 11.5 0.0 4.4 6.3 0.0 2.3 1 1 0 2 2 2 0 VID27 C-terminal WD40-like domain DUF5570 PF17731.1 ETO36856.1 - 0.12 12.5 7.5 11 6.2 0.0 3.8 3 2 1 4 4 4 0 Family of unknown function (DUF5570) PT PF04886.12 ETO36857.1 - 2.5e-13 49.3 77.4 0.00013 21.4 4.6 6.3 1 1 3 4 4 4 3 PT repeat TMIE PF16038.5 ETO36857.1 - 0.056 13.3 1.1 0.069 13.0 0.1 1.6 2 0 0 2 2 2 0 TMIE protein DUF4101 PF13355.6 ETO36858.1 - 0.0079 16.6 0.0 0.025 15.0 0.0 1.9 1 0 0 1 1 1 1 Protein of unknown function (DUF4101) TRP PF06011.12 ETO36859.1 - 0.012 14.3 5.6 0.023 13.4 5.6 1.5 1 1 0 1 1 1 0 Transient receptor potential (TRP) ion channel DUF4153 PF13687.6 ETO36859.1 - 0.072 12.7 8.0 0.057 13.0 2.4 2.6 3 0 0 3 3 3 0 Domain of unknown function (DUF4153) DUF3328 PF11807.8 ETO36859.1 - 1.4 8.7 3.5 0.48 10.2 0.1 1.8 2 0 0 2 2 2 0 Domain of unknown function (DUF3328) OAD_gamma PF04277.13 ETO36859.1 - 7.9 7.1 5.8 0.84 10.3 0.3 2.1 2 0 0 2 2 2 0 Oxaloacetate decarboxylase, gamma chain STAT_bind PF02864.15 ETO36860.1 - 0.004 17.7 1.4 0.011 16.3 0.9 1.9 2 0 0 2 2 2 1 STAT protein, DNA binding domain WD40 PF00400.32 ETO36861.1 - 6.9e-30 102.7 30.7 8.8e-06 26.4 1.4 8.1 7 2 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36861.1 - 4.5e-11 42.9 0.6 0.011 16.0 0.0 5.6 5 1 1 6 6 6 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36861.1 - 5.3e-08 32.0 3.9 0.1 11.2 0.0 5.4 3 1 2 5 5 5 4 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36861.1 - 3.7e-05 23.2 4.9 0.28 10.5 0.1 4.5 2 2 4 6 6 6 3 WD40-like domain PKcGMP_CC PF16808.5 ETO36863.1 - 0.21 11.5 5.2 2.8 7.8 0.2 4.0 3 0 0 3 3 3 0 Coiled-coil N-terminus of cGMP-dependent protein kinase GCP_N_terminal PF17681.1 ETO36864.1 - 0.00015 21.5 1.4 0.00015 21.5 1.4 1.6 2 0 0 2 2 2 1 Gamma tubulin complex component N-terminal Sec2p PF06428.11 ETO36864.1 - 0.028 14.4 1.3 0.085 12.8 1.3 1.8 1 0 0 1 1 1 0 GDP/GTP exchange factor Sec2p DUF3907 PF13047.6 ETO36864.1 - 0.03 14.3 1.9 0.44 10.5 0.3 2.3 2 0 0 2 2 2 0 Protein of unknown function (DUF3907) SKA2 PF16740.5 ETO36864.1 - 0.1 12.4 6.4 0.041 13.7 1.9 2.2 2 0 0 2 2 2 0 Spindle and kinetochore-associated protein 2 RGS PF00615.19 ETO36865.1 - 7e-05 23.1 0.1 9.4e-05 22.7 0.1 1.3 1 0 0 1 1 1 1 Regulator of G protein signaling domain AAA_16 PF13191.6 ETO36866.1 - 2.9e-08 34.3 0.0 6.4e-08 33.2 0.0 1.5 1 0 0 1 1 1 1 AAA ATPase domain ORC4_C PF14629.6 ETO36866.1 - 1.5e-07 31.0 0.9 3.3e-07 29.9 0.9 1.6 1 1 0 1 1 1 1 Origin recognition complex (ORC) subunit 4 C-terminus KAP_NTPase PF07693.14 ETO36866.1 - 6.9e-05 22.2 0.0 0.00015 21.2 0.0 1.6 1 0 0 1 1 1 1 KAP family P-loop domain AAA_22 PF13401.6 ETO36866.1 - 0.0007 19.9 0.0 0.002 18.4 0.0 1.8 1 0 0 1 1 1 1 AAA domain DUF815 PF05673.13 ETO36866.1 - 0.00073 18.8 0.1 0.0014 17.9 0.1 1.4 1 0 0 1 1 1 1 Protein of unknown function (DUF815) ABC_tran PF00005.27 ETO36866.1 - 0.0043 17.6 0.0 0.014 15.9 0.0 2.0 1 1 0 1 1 1 1 ABC transporter AAA PF00004.29 ETO36866.1 - 0.01 16.2 0.1 0.084 13.3 0.1 2.3 1 1 0 1 1 1 0 ATPase family associated with various cellular activities (AAA) AAA_7 PF12775.7 ETO36866.1 - 0.011 15.3 0.0 0.028 13.9 0.0 1.7 1 0 0 1 1 1 0 P-loop containing dynein motor region RsgA_GTPase PF03193.16 ETO36866.1 - 0.077 12.9 0.0 0.17 11.8 0.0 1.6 1 0 0 1 1 1 0 RsgA GTPase Sigma54_activat PF00158.26 ETO36866.1 - 0.099 12.3 0.0 0.21 11.3 0.0 1.4 1 0 0 1 1 1 0 Sigma-54 interaction domain Ribosomal_L11_N PF03946.14 ETO36867.1 - 1.9e-13 50.0 0.0 3.4e-13 49.2 0.0 1.4 1 0 0 1 1 1 1 Ribosomal protein L11, N-terminal domain Ras PF00071.22 ETO36868.1 - 1.3e-45 155.0 0.6 2.1e-45 154.2 0.6 1.3 1 0 0 1 1 1 1 Ras family Roc PF08477.13 ETO36868.1 - 1.6e-21 76.8 0.3 3.1e-21 75.8 0.3 1.6 1 0 0 1 1 1 1 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO36868.1 - 8.7e-09 35.1 0.4 1.1e-08 34.7 0.4 1.3 1 0 0 1 1 1 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO36868.1 - 9.8e-06 25.2 0.9 1.4e-05 24.7 0.9 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain F-box-like PF12937.7 ETO36869.1 - 0.15 12.0 0.6 0.67 9.9 0.6 2.2 1 1 0 1 1 1 0 F-box-like Laminin_II PF06009.12 ETO36870.1 - 0.009 16.0 0.2 0.021 14.9 0.2 1.8 1 0 0 1 1 1 1 Laminin Domain II Enkurin PF13864.6 ETO36870.1 - 0.034 14.6 1.4 0.1 13.1 1.4 1.7 1 1 1 2 2 2 0 Calmodulin-binding DUF2854 PF11016.8 ETO36870.1 - 0.11 12.3 0.2 0.18 11.7 0.2 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF2854) Skp1 PF01466.19 ETO36871.1 - 3.9e-08 33.3 0.0 1.2e-07 31.7 0.0 1.9 2 0 0 2 2 2 1 Skp1 family, dimerisation domain Skp1_POZ PF03931.15 ETO36871.1 - 2.3e-06 27.7 1.8 3e-05 24.1 0.0 2.7 3 0 0 3 3 3 1 Skp1 family, tetramerisation domain Img2 PF05046.14 ETO36871.1 - 0.14 12.5 0.1 0.45 10.9 0.1 1.8 1 1 0 1 1 1 0 Mitochondrial large subunit ribosomal protein (Img2) Cofilin_ADF PF00241.20 ETO36873.1 - 9.1e-10 38.4 0.0 1.3e-09 37.9 0.0 1.2 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein WD40 PF00400.32 ETO36875.1 - 1.9e-65 215.2 14.0 7.1e-11 42.5 0.1 7.7 7 1 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36875.1 - 1.3e-24 86.3 2.6 0.00016 21.9 0.1 6.2 1 1 4 5 5 5 5 Anaphase-promoting complex subunit 4 WD40 domain Ge1_WD40 PF16529.5 ETO36875.1 - 2.4e-15 56.3 0.9 0.019 13.9 0.0 6.2 1 1 5 6 6 6 5 WD40 region of Ge1, enhancer of mRNA-decapping protein WD40_like PF17005.5 ETO36875.1 - 3.2e-09 36.5 3.4 0.029 13.7 0.0 4.2 1 1 3 4 4 4 3 WD40-like domain Nup160 PF11715.8 ETO36875.1 - 1.4e-07 30.6 8.2 0.95 8.0 0.0 5.9 1 1 4 6 6 6 4 Nucleoporin Nup120/160 DUF5570 PF17731.1 ETO36875.1 - 1.1e-05 25.6 2.1 12 6.0 0.0 5.7 2 1 4 6 6 6 1 Family of unknown function (DUF5570) PD40 PF07676.12 ETO36875.1 - 4.6e-05 23.2 6.5 23 5.1 0.1 6.2 6 0 0 6 6 6 0 WD40-like Beta Propeller Repeat Nbas_N PF15492.6 ETO36875.1 - 0.00082 18.8 0.5 0.14 11.5 0.0 3.6 1 1 3 4 4 4 1 Neuroblastoma-amplified sequence, N terminal Nucleoporin_N PF08801.11 ETO36875.1 - 0.0038 16.0 3.8 5.6 5.6 0.0 4.2 1 1 3 4 4 4 2 Nup133 N terminal like Cytochrom_D1 PF02239.16 ETO36875.1 - 0.053 12.0 0.1 2.8 6.4 0.0 2.8 1 1 1 2 2 2 0 Cytochrome D1 heme domain Big_7 PF17957.1 ETO36875.1 - 0.081 13.7 0.2 16 6.3 0.0 3.4 3 0 0 3 3 3 0 Bacterial Ig domain Proteasome_A_N PF10584.9 ETO36875.1 - 0.17 11.6 3.2 90 2.9 0.0 4.7 6 0 0 6 6 6 0 Proteasome subunit A N-terminal signature DUF4999 PF16390.5 ETO36875.1 - 0.43 10.9 6.1 43 4.4 0.0 4.5 5 0 0 5 5 5 0 Domain of unknown function SecA_DEAD PF07517.14 ETO36876.1 - 3.9e-09 36.2 0.0 1.6e-08 34.2 0.0 2.1 1 0 0 1 1 1 1 SecA DEAD-like domain Helicase_C PF00271.31 ETO36876.1 - 0.00037 20.8 0.1 0.0027 18.1 0.1 2.6 1 0 0 1 1 1 1 Helicase conserved C-terminal domain DUF3783 PF12646.7 ETO36876.1 - 0.065 13.2 1.6 5.7 7.0 0.0 3.8 3 0 0 3 3 3 0 Domain of unknown function (DUF3783) zf-4CXXC_R1 PF10497.9 ETO36876.1 - 0.076 13.2 1.2 0.22 11.8 1.2 1.8 1 0 0 1 1 1 0 Zinc-finger domain of monoamine-oxidase A repressor R1 DASH_Dad4 PF08650.10 ETO36876.1 - 0.49 10.4 4.5 9.7 6.2 0.1 4.0 3 0 0 3 3 3 0 DASH complex subunit Dad4 HEAT_EZ PF13513.6 ETO36877.1 - 3.2e-07 30.7 2.8 0.0051 17.3 0.0 5.2 7 0 0 7 7 7 1 HEAT-like repeat CLASP_N PF12348.8 ETO36877.1 - 3.8e-06 26.6 0.1 0.28 10.7 0.0 4.0 4 1 0 4 4 4 2 CLASP N terminal IBN_N PF03810.19 ETO36877.1 - 0.00025 20.9 0.0 0.002 18.0 0.0 2.7 1 0 0 1 1 1 1 Importin-beta N-terminal domain Adaptin_N PF01602.20 ETO36877.1 - 0.0012 17.5 5.3 0.77 8.2 0.8 3.5 2 2 0 2 2 2 2 Adaptin N terminal region Cnd1 PF12717.7 ETO36877.1 - 0.0081 16.2 0.5 0.6 10.1 0.0 3.5 2 2 0 2 2 2 1 non-SMC mitotic condensation complex subunit 1 Xpo1 PF08389.12 ETO36877.1 - 0.0085 16.2 4.1 0.022 14.8 0.0 3.7 4 0 0 4 4 4 1 Exportin 1-like protein Clathrin-link PF09268.10 ETO36877.1 - 1.3 8.4 3.6 0.38 10.1 0.1 2.0 2 0 0 2 2 2 0 Clathrin, heavy-chain linker zf-RING_2 PF13639.6 ETO36878.1 - 1.1e-10 41.6 7.4 2.4e-10 40.6 7.4 1.6 1 0 0 1 1 1 1 Ring finger domain zf-rbx1 PF12678.7 ETO36878.1 - 4.2e-08 33.4 8.3 1.1e-07 32.0 8.3 1.7 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4_2 PF13923.6 ETO36878.1 - 1.3e-07 31.4 7.7 2.4e-07 30.5 7.7 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4_3 PF13920.6 ETO36878.1 - 7.7e-07 28.9 4.0 1.5e-06 28.0 4.0 1.4 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-C3HC4 PF00097.25 ETO36878.1 - 1e-06 28.5 5.9 1.9e-06 27.7 5.9 1.5 1 0 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO36878.1 - 7.8e-06 25.8 6.0 1.3e-05 25.0 6.0 1.4 1 0 0 1 1 1 1 zinc-RING finger domain zf-ANAPC11 PF12861.7 ETO36878.1 - 4.6e-05 23.4 2.4 0.00011 22.2 2.4 1.6 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 11 RING-H2 finger Prok-RING_4 PF14447.6 ETO36878.1 - 0.0001 22.1 3.7 0.0002 21.2 3.7 1.4 1 0 0 1 1 1 1 Prokaryotic RING finger family 4 Zn_ribbon_17 PF17120.5 ETO36878.1 - 0.00013 21.5 4.0 0.00031 20.3 4.0 1.6 1 0 0 1 1 1 1 Zinc-ribbon, C4HC2 type zf-RING_11 PF17123.5 ETO36878.1 - 0.00016 21.3 4.6 0.00056 19.6 4.6 1.9 1 0 0 1 1 1 1 RING-like zinc finger zf-RING_UBOX PF13445.6 ETO36878.1 - 0.00049 20.1 4.9 0.0011 19.0 4.9 1.6 1 0 0 1 1 1 1 RING-type zinc-finger RINGv PF12906.7 ETO36878.1 - 0.011 15.8 4.0 0.028 14.5 4.0 1.7 1 1 0 1 1 1 0 RING-variant domain zinc_ribbon_16 PF17034.5 ETO36878.1 - 0.066 13.4 0.3 0.14 12.4 0.3 1.5 1 0 0 1 1 1 0 Zinc-ribbon like family zf-Nse PF11789.8 ETO36878.1 - 0.14 12.0 1.4 0.28 11.0 1.4 1.4 1 0 0 1 1 1 0 Zinc-finger of the MIZ type in Nse subunit zf-C3HC4_4 PF15227.6 ETO36878.1 - 0.3 11.3 5.0 1.9 8.7 5.7 2.1 1 1 1 2 2 2 0 zinc finger of C3HC4-type, RING FANCL_C PF11793.8 ETO36878.1 - 0.31 11.2 9.8 5.1 7.4 8.0 3.3 2 1 0 2 2 2 0 FANCL C-terminal domain zf-RING-like PF08746.11 ETO36878.1 - 0.64 10.4 5.6 1.2 9.5 5.6 1.5 1 0 0 1 1 1 0 RING-like domain Tmpp129 PF10272.9 ETO36878.1 - 1.3 8.2 9.0 1.7 7.9 1.2 2.5 2 1 0 2 2 2 0 Putative transmembrane protein precursor Abhydrolase_9_N PF15420.6 ETO36878.1 - 2.2 8.3 7.2 2.1 8.3 5.3 1.9 1 1 0 1 1 1 0 Alpha/beta-hydrolase family N-terminus zf-RING_4 PF14570.6 ETO36878.1 - 5.2 6.9 9.3 1.6 8.6 5.6 2.2 2 1 0 2 2 2 0 RING/Ubox like zinc-binding domain ANAPC4_WD40 PF12894.7 ETO36879.1 - 2.5e-05 24.5 0.1 4.5e-05 23.7 0.1 1.5 1 0 0 1 1 1 1 Anaphase-promoting complex subunit 4 WD40 domain Sec62 PF03839.16 ETO36879.1 - 1.8 8.0 8.1 0.46 10.0 0.3 2.2 2 0 0 2 2 2 0 Translocation protein Sec62 U-box PF04564.15 ETO36881.1 - 9.6e-11 41.7 0.0 4.1e-10 39.7 0.0 2.1 1 1 0 1 1 1 1 U-box domain Methyltr_RsmF_N PF17125.5 ETO36881.1 - 1.7 9.2 4.9 3.1 8.4 0.1 3.5 3 0 0 3 3 3 0 N-terminal domain of 16S rRNA methyltransferase RsmF DUF745 PF05335.13 ETO36881.1 - 3.2 7.4 7.0 10 5.8 7.0 1.8 1 0 0 1 1 1 0 Protein of unknown function (DUF745) HAGH_C PF16123.5 ETO36881.1 - 4.7 7.8 8.9 0.57 10.7 2.5 2.8 2 1 1 3 3 3 0 Hydroxyacylglutathione hydrolase C-terminus DUF155 PF02582.14 ETO36882.1 - 0.00063 19.9 0.1 0.001 19.2 0.1 1.4 1 0 0 1 1 1 1 Uncharacterised ACR, YagE family COG1723 ETRAMP PF09716.10 ETO36882.1 - 0.056 13.5 0.0 0.3 11.2 0.0 2.4 1 1 0 1 1 1 0 Malarial early transcribed membrane protein (ETRAMP) 3Beta_HSD PF01073.19 ETO36883.1 - 5.1e-10 38.8 0.0 5.8e-10 38.6 0.0 1.1 1 0 0 1 1 1 1 3-beta hydroxysteroid dehydrogenase/isomerase family Epimerase PF01370.21 ETO36883.1 - 9.3e-10 38.4 0.0 1.1e-09 38.1 0.0 1.0 1 0 0 1 1 1 1 NAD dependent epimerase/dehydratase family GDP_Man_Dehyd PF16363.5 ETO36883.1 - 1.6e-06 27.7 0.0 2.4e-06 27.2 0.0 1.2 1 0 0 1 1 1 1 GDP-mannose 4,6 dehydratase NAD_binding_4 PF07993.12 ETO36883.1 - 6e-06 25.6 0.0 1.2e-05 24.6 0.0 1.5 1 1 0 1 1 1 1 Male sterility protein Sacchrp_dh_NADP PF03435.18 ETO36883.1 - 0.0022 18.3 0.1 0.0036 17.6 0.1 1.5 1 1 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Polysacc_synt_2 PF02719.15 ETO36883.1 - 0.0035 16.5 0.0 0.0043 16.2 0.0 1.1 1 0 0 1 1 1 1 Polysaccharide biosynthesis protein KR PF08659.10 ETO36883.1 - 0.0037 17.2 0.0 0.0048 16.8 0.0 1.3 1 1 0 1 1 1 1 KR domain NAD_binding_10 PF13460.6 ETO36883.1 - 0.008 16.1 0.0 0.013 15.4 0.0 1.3 1 0 0 1 1 1 1 NAD(P)H-binding Ldh_1_N PF00056.23 ETO36883.1 - 0.02 15.0 0.1 0.034 14.2 0.1 1.5 1 1 0 1 1 1 0 lactate/malate dehydrogenase, NAD binding domain NmrA PF05368.13 ETO36883.1 - 0.081 12.5 0.0 0.11 12.0 0.0 1.1 1 0 0 1 1 1 0 NmrA-like family Stevor PF17410.2 ETO36884.1 - 0.086 12.4 1.4 0.19 11.2 1.4 1.5 1 0 0 1 1 1 0 Subtelomeric Variable Open Reading frame DUF4064 PF13273.6 ETO36884.1 - 0.53 10.6 11.7 2.9 8.2 0.7 2.9 2 1 0 2 2 2 0 Protein of unknown function (DUF4064) AAR2 PF05282.11 ETO36885.1 - 1.9 7.8 8.9 0.1 12.0 3.8 1.5 2 0 0 2 2 2 0 AAR2 protein EF-hand_1 PF00036.32 ETO36886.1 - 3.3e-07 29.4 0.4 2.6e-06 26.6 0.5 2.5 2 0 0 2 2 2 1 EF hand EF-hand_7 PF13499.6 ETO36886.1 - 2e-05 24.9 3.9 0.00076 19.9 1.0 3.3 2 1 0 2 2 2 1 EF-hand domain pair EF-hand_6 PF13405.6 ETO36886.1 - 3.7e-05 23.3 0.4 3.7e-05 23.3 0.4 2.8 3 0 0 3 3 3 1 EF-hand domain EF-hand_5 PF13202.6 ETO36886.1 - 4.7e-05 22.7 0.3 0.00012 21.4 0.3 1.7 1 0 0 1 1 1 1 EF hand RasGEF_N_2 PF14663.6 ETO36886.1 - 0.016 15.6 9.2 0.97 9.9 3.7 2.8 3 0 0 3 3 3 0 Rapamycin-insensitive companion of mTOR RasGEF_N domain Caleosin PF05042.13 ETO36886.1 - 0.079 12.9 0.1 0.079 12.9 0.1 2.7 2 1 0 3 3 3 0 Caleosin related protein EF-hand_8 PF13833.6 ETO36886.1 - 0.13 12.1 1.5 0.52 10.2 0.3 2.5 2 0 0 2 2 2 0 EF-hand domain pair ERM PF00769.19 ETO36886.1 - 0.42 10.4 34.0 0.97 9.2 15.9 2.3 1 1 1 2 2 2 0 Ezrin/radixin/moesin family MMR_HSR1_C PF08438.10 ETO36886.1 - 1.9 9.1 5.3 3.3 8.3 0.4 3.1 3 1 0 3 3 3 0 GTPase of unknown function C-terminal WD40 PF00400.32 ETO36887.1 - 0.0011 19.8 0.3 0.0032 18.3 0.0 2.0 2 0 0 2 2 2 1 WD domain, G-beta repeat Saf_2TM PF18303.1 ETO36888.1 - 0.22 11.1 2.2 2.9 7.5 0.2 2.4 1 1 1 2 2 2 0 SAVED-fused 2TM effector domain WD40 PF00400.32 ETO36890.1 - 6.1e-128 413.0 64.9 3.7e-09 37.1 0.2 16.4 16 0 0 16 16 16 16 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36890.1 - 2e-24 85.7 20.6 0.03 14.6 0.4 12.6 1 1 12 13 13 13 8 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36890.1 - 4e-18 65.8 26.4 0.00014 21.3 0.2 8.3 4 3 5 9 9 9 8 WD40-like domain Ge1_WD40 PF16529.5 ETO36890.1 - 8.4e-15 54.5 9.7 0.13 11.2 0.0 11.3 2 2 8 12 12 12 5 WD40 region of Ge1, enhancer of mRNA-decapping protein Pentapeptide PF00805.22 ETO36890.1 - 6.6e-08 32.1 0.5 1.5e-07 30.9 0.5 1.5 1 0 0 1 1 1 1 Pentapeptide repeats (8 copies) POLO_box PF00659.18 ETO36890.1 - 4.6e-06 26.7 9.5 1.1 9.5 0.0 8.5 6 2 0 8 8 8 2 POLO box duplicated region Cytochrom_D1 PF02239.16 ETO36890.1 - 3.2e-05 22.6 9.3 2 6.9 0.0 6.2 4 2 1 6 6 6 2 Cytochrome D1 heme domain Pentapeptide_4 PF13599.6 ETO36890.1 - 0.00034 20.7 0.1 0.0009 19.4 0.1 1.7 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) PD40 PF07676.12 ETO36890.1 - 0.00097 19.0 13.1 1.3 9.1 0.0 6.1 8 0 0 8 8 8 2 WD40-like Beta Propeller Repeat Pentapeptide_3 PF13576.6 ETO36890.1 - 0.0049 17.0 0.4 0.012 15.7 0.4 1.6 1 0 0 1 1 1 1 Pentapeptide repeats (9 copies) DUF3870 PF12986.7 ETO36890.1 - 0.74 10.1 3.2 1.3 9.3 0.1 3.0 4 0 0 4 4 4 0 Domain of unknown function (DUF3870) DUF1438 PF07270.11 ETO36890.1 - 2.1 8.4 8.4 17 5.5 0.1 4.5 4 2 0 4 4 4 0 Protein of unknown function (DUF1438) DUF1944 PF09175.10 ETO36892.1 - 0.096 12.5 0.0 0.14 12.0 0.0 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF1944) PAH PF02671.21 ETO36893.1 - 2.5e-05 24.3 0.1 3.5e-05 23.9 0.1 1.2 1 0 0 1 1 1 1 Paired amphipathic helix repeat CAP_N PF01213.19 ETO36893.1 - 0.0034 16.9 1.2 0.0042 16.6 1.2 1.2 1 0 0 1 1 1 1 Adenylate cyclase associated (CAP) N terminal Reprolysin_2 PF13574.6 ETO36893.1 - 0.024 14.5 0.0 0.03 14.2 0.0 1.1 1 0 0 1 1 1 0 Metallo-peptidase family M12B Reprolysin-like DUF2615 PF11027.8 ETO36893.1 - 0.11 12.7 4.5 0.22 11.7 4.5 1.5 1 0 0 1 1 1 0 Protein of unknown function (DUF2615) Dscam_C PF12355.8 ETO36893.1 - 0.17 12.9 7.1 0.25 12.3 7.1 1.4 1 0 0 1 1 1 0 Down syndrome cell adhesion molecule C terminal CpxA_peri PF16527.5 ETO36894.1 - 0.0074 16.7 1.5 0.0081 16.5 1.5 1.2 1 0 0 1 1 1 1 Two-component sensor protein CpxA, periplasmic domain DUF496 PF04363.12 ETO36894.1 - 0.015 15.3 4.3 0.034 14.2 0.2 2.1 2 0 0 2 2 2 0 Protein of unknown function (DUF496) Leu_zip PF15294.6 ETO36895.1 - 0.0017 17.9 11.2 0.0022 17.6 11.2 1.1 1 0 0 1 1 1 1 Leucine zipper DUF87 PF01935.17 ETO36895.1 - 0.03 14.4 4.2 0.037 14.1 4.2 1.1 1 0 0 1 1 1 0 Helicase HerA, central domain DUF4298 PF14131.6 ETO36895.1 - 0.084 12.8 3.2 0.17 11.8 3.2 1.5 1 0 0 1 1 1 0 Domain of unknown function (DUF4298) LMBR1 PF04791.16 ETO36895.1 - 0.97 8.3 4.2 1.2 8.0 4.2 1.2 1 0 0 1 1 1 0 LMBR1-like membrane protein CENP-B_N PF04218.13 ETO36895.1 - 4.5 7.0 9.7 1.6 8.4 4.4 2.5 2 1 1 3 3 3 0 CENP-B N-terminal DNA-binding domain MAP17 PF15807.5 ETO36896.1 - 3 8.1 8.0 3.2 8.0 8.0 1.2 1 0 0 1 1 1 0 Membrane-associated protein 117 kDa, PDZK1-interacting protein 1 GTP-bdg_M PF16360.5 ETO36897.1 - 0.0081 16.7 3.1 2 9.1 0.2 2.3 2 0 0 2 2 2 2 GTP-binding GTPase Middle Region APG6_N PF17675.1 ETO36898.1 - 4.5e-05 24.0 10.8 4.5e-05 24.0 10.8 1.8 2 0 0 2 2 2 1 Apg6 coiled-coil region Golgin_A5 PF09787.9 ETO36898.1 - 0.0071 15.9 10.0 0.0071 15.9 10.0 1.5 2 0 0 2 2 2 1 Golgin subfamily A member 5 FapA PF03961.13 ETO36898.1 - 0.072 11.7 12.0 0.063 11.9 11.5 1.2 1 1 0 1 1 1 0 Flagellar Assembly Protein A DUF724 PF05266.14 ETO36898.1 - 1.1 9.1 12.6 0.36 10.6 8.4 2.0 1 1 2 3 3 3 0 Protein of unknown function (DUF724) LMBR1 PF04791.16 ETO36898.1 - 2.2 7.1 7.4 2.3 7.0 7.4 1.1 1 0 0 1 1 1 0 LMBR1-like membrane protein OrfB_IS605 PF01385.19 ETO36898.1 - 3.8 7.8 14.7 1.5 9.1 1.1 3.0 1 1 2 3 3 3 0 Probable transposase DUF4200 PF13863.6 ETO36898.1 - 4.1 7.8 20.2 0.19 12.1 13.3 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF4200) YbfN PF13982.6 ETO36898.1 - 4.3 7.7 8.5 14 6.1 0.3 3.0 2 1 1 3 3 3 0 YbfN-like lipoprotein VPS9 PF02204.18 ETO36899.1 - 2.8e-11 43.6 0.7 4.9e-07 29.9 0.1 2.3 2 0 0 2 2 2 2 Vacuolar sorting protein 9 (VPS9) domain BUD22 PF09073.10 ETO36899.1 - 0.00081 18.8 11.3 0.0011 18.5 11.3 1.2 1 0 0 1 1 1 1 BUD22 DUF5093 PF17011.5 ETO36899.1 - 0.0029 17.9 0.3 0.0078 16.5 0.3 1.7 1 0 0 1 1 1 1 Domain of unknown function (DUF5093) CDC45 PF02724.14 ETO36899.1 - 0.0064 14.8 9.7 0.0087 14.4 9.7 1.2 1 0 0 1 1 1 1 CDC45-like protein DNA_pol_phi PF04931.13 ETO36899.1 - 0.064 11.4 23.0 0.093 10.8 23.0 1.3 1 0 0 1 1 1 0 DNA polymerase phi SDA1 PF05285.12 ETO36899.1 - 0.1 12.0 18.5 0.17 11.3 18.5 1.3 1 0 0 1 1 1 0 SDA1 RNA_pol_Rpc4 PF05132.14 ETO36899.1 - 0.13 12.7 0.3 0.13 12.7 0.3 2.0 2 0 0 2 2 2 0 RNA polymerase III RPC4 Nop14 PF04147.12 ETO36899.1 - 0.22 9.7 20.5 0.33 9.1 20.5 1.2 1 0 0 1 1 1 0 Nop14-like family CobT PF06213.12 ETO36899.1 - 1.7 8.0 15.0 2.5 7.4 15.0 1.2 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT DUF2076 PF09849.9 ETO36899.1 - 2.3 8.2 15.9 4.2 7.3 15.9 1.4 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2076) RRN3 PF05327.11 ETO36899.1 - 2.7 6.4 13.3 3.7 6.0 13.3 1.2 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 ParD PF09386.10 ETO36900.1 - 0.05 14.0 1.6 0.48 10.8 0.2 2.6 2 1 1 3 3 3 0 Antitoxin ParD WD40 PF00400.32 ETO36901.1 - 7.1e-21 74.1 18.8 7.4e-06 26.6 1.4 4.9 4 2 0 4 4 4 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36901.1 - 3.8e-05 23.9 1.0 0.81 10.0 0.1 3.4 3 1 1 4 4 4 3 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36901.1 - 0.00014 20.7 2.2 0.036 12.7 0.1 2.8 2 1 1 3 3 3 2 Nucleoporin Nup120/160 LRR_6 PF13516.6 ETO36905.1 - 5.1e-08 32.4 13.6 0.05 13.7 0.0 6.6 7 0 0 7 7 7 4 Leucine Rich repeat LRR_6 PF13516.6 ETO36907.1 - 3e-13 48.7 14.1 0.026 14.5 0.0 7.5 7 0 0 7 7 7 4 Leucine Rich repeat LRR_1 PF00560.33 ETO36907.1 - 0.0017 18.6 5.1 2.3e+02 3.0 0.0 6.6 6 0 0 6 6 6 0 Leucine Rich Repeat LRR_8 PF13855.6 ETO36907.1 - 0.032 14.0 5.0 26 4.7 0.0 5.3 3 2 2 5 5 5 0 Leucine rich repeat Kelch_1 PF01344.25 ETO36908.1 - 7.8e-07 28.6 1.2 0.0011 18.5 0.1 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_5 PF13854.6 ETO36908.1 - 2.8e-05 24.0 1.6 0.47 10.5 0.1 4.8 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO36908.1 - 8e-05 22.6 0.1 0.055 13.5 0.0 3.5 4 0 0 4 4 4 2 Galactose oxidase, central domain Kelch_2 PF07646.15 ETO36908.1 - 0.00051 19.9 6.1 0.98 9.5 0.8 5.0 5 1 0 5 5 5 2 Kelch motif Kelch_6 PF13964.6 ETO36908.1 - 0.00091 19.4 5.6 2.4 8.6 0.2 4.6 4 1 1 5 5 5 2 Kelch motif Symplekin_C PF12295.8 ETO36909.1 - 0.034 14.2 0.1 0.047 13.8 0.1 1.1 1 0 0 1 1 1 0 Symplekin tight junction protein C terminal Methyltransf_FA PF12248.8 ETO36910.1 - 3.7e-28 97.8 1.0 6.2e-28 97.1 1.0 1.4 1 0 0 1 1 1 1 Farnesoic acid 0-methyl transferase DnaJ PF00226.31 ETO36911.1 - 2.6e-23 81.9 4.0 4.3e-19 68.4 0.9 2.9 2 0 0 2 2 2 2 DnaJ domain UreE_C PF05194.12 ETO36911.1 - 0.078 13.5 9.6 0.24 11.9 9.6 1.8 1 0 0 1 1 1 0 UreE urease accessory protein, C-terminal domain CCDC53 PF10152.9 ETO36911.1 - 3.1 8.2 12.7 1.5 9.2 6.2 2.2 2 0 0 2 2 2 0 Subunit CCDC53 of WASH complex BORG_CEP PF14957.6 ETO36911.1 - 6.1 8.0 10.9 3.4 8.8 5.2 2.5 2 0 0 2 2 2 0 Cdc42 effector HSP70 PF00012.20 ETO36912.1 - 6.5e-05 21.3 0.0 8.5e-05 20.9 0.0 1.1 1 0 0 1 1 1 1 Hsp70 protein Peptidase_M22 PF00814.25 ETO36912.1 - 0.039 13.6 0.0 0.063 13.0 0.0 1.2 1 0 0 1 1 1 0 Glycoprotease family HSP70 PF00012.20 ETO36913.1 - 0.00018 19.8 0.0 0.00022 19.5 0.0 1.2 1 0 0 1 1 1 1 Hsp70 protein LNS2 PF08235.13 ETO36914.1 - 2.5e-91 305.2 0.2 4.3e-91 304.4 0.2 1.3 1 0 0 1 1 1 1 LNS2 (Lipin/Ned1/Smp2) Lipin_N PF04571.14 ETO36914.1 - 2e-23 82.3 0.1 2.2e-22 78.9 0.1 2.6 1 1 0 1 1 1 1 lipin, N-terminal conserved region Lipin_mid PF16876.5 ETO36914.1 - 5e-18 65.1 0.2 5e-18 65.1 0.2 3.6 3 1 0 3 3 3 1 Lipin/Ned1/Smp2 multi-domain protein middle domain FAM221 PF14753.6 ETO36915.1 - 0.00069 19.2 0.8 0.0031 17.1 0.0 2.1 1 1 1 2 2 2 1 Protein FAM221A/B MRP-63 PF14978.6 ETO36915.1 - 6.6 7.4 7.8 0.97 10.1 1.3 2.1 1 1 1 2 2 2 0 Mitochondrial ribosome protein 63 CUE PF02845.16 ETO36916.1 - 0.0027 17.4 0.0 0.0049 16.6 0.0 1.4 1 0 0 1 1 1 1 CUE domain PUB PF09409.10 ETO36916.1 - 0.014 15.3 0.5 0.16 11.9 0.5 2.4 1 1 0 1 1 1 0 PUB domain SET PF00856.28 ETO36917.1 - 0.0098 16.3 0.0 0.0098 16.3 0.0 3.6 3 1 0 3 3 3 1 SET domain zf-C2H2 PF00096.26 ETO36917.1 - 0.018 15.5 0.5 0.018 15.5 0.5 5.9 7 0 0 7 7 7 0 Zinc finger, C2H2 type CPSF100_C PF13299.6 ETO36917.1 - 0.82 9.8 0.0 0.82 9.8 0.0 5.2 5 1 1 6 6 6 0 Cleavage and polyadenylation factor 2 C-terminal SET PF00856.28 ETO36918.1 - 8.1e-10 39.3 1.1 8.1e-10 39.3 1.1 2.4 2 1 0 2 2 2 1 SET domain AWS PF17907.1 ETO36918.1 - 9.4e-06 25.6 12.3 9.4e-06 25.6 12.3 2.8 4 0 0 4 4 4 1 AWS domain PriX PF18689.1 ETO36918.1 - 0.11 12.9 1.8 0.14 12.5 0.6 1.7 1 1 0 1 1 1 0 Primase X Exo_endo_phos_2 PF14529.6 ETO36919.1 - 1.2e-07 31.6 2.1 4.2e-06 26.6 2.2 2.5 1 1 0 1 1 1 1 Endonuclease-reverse transcriptase RRM_1 PF00076.22 ETO36921.1 - 0.0027 17.5 0.1 0.052 13.4 0.0 2.2 1 1 1 2 2 2 1 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Presenilin PF01080.17 ETO36921.1 - 1.5 7.5 3.5 2.1 7.0 3.5 1.1 1 0 0 1 1 1 0 Presenilin MAS20 PF02064.15 ETO36921.1 - 2.2 8.4 9.0 1.8 8.7 0.9 2.4 2 0 0 2 2 2 0 MAS20 protein import receptor Ribonuc_red_lgC PF02867.15 ETO36922.1 - 1.2e-40 139.5 0.0 1.5e-40 139.3 0.0 1.1 1 0 0 1 1 1 1 Ribonucleotide reductase, barrel domain Ribonuc_red_lgC PF02867.15 ETO36923.1 - 3.5e-121 405.3 2.0 2.7e-104 349.6 0.0 2.1 2 0 0 2 2 2 2 Ribonucleotide reductase, barrel domain WD40 PF00400.32 ETO36924.1 - 8.3e-33 111.9 26.5 1.9e-07 31.7 0.8 6.8 6 0 0 6 6 6 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36924.1 - 8e-11 42.1 2.4 0.0034 17.6 0.0 5.4 5 1 0 5 5 5 3 Anaphase-promoting complex subunit 4 WD40 domain WD40_like PF17005.5 ETO36924.1 - 4.4e-05 22.9 8.6 0.38 10.0 0.0 4.2 4 1 1 5 5 5 3 WD40-like domain Nup160 PF11715.8 ETO36924.1 - 0.00013 20.7 3.8 0.051 12.2 1.3 3.4 3 1 0 3 3 3 2 Nucleoporin Nup120/160 Actin PF00022.19 ETO36925.1 - 1.5e-70 237.9 0.0 1e-69 235.1 0.0 1.8 1 1 0 1 1 1 1 Actin Pkinase PF00069.25 ETO36926.1 - 7.1e-15 55.1 0.0 1.8e-11 43.9 0.0 2.2 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36926.1 - 6.7e-05 22.3 0.1 0.085 12.1 0.0 2.1 1 1 1 2 2 2 2 Protein tyrosine kinase Pox_RNA_Pol_19 PF05320.12 ETO36926.1 - 0.021 14.8 0.9 0.024 14.6 0.9 1.2 1 0 0 1 1 1 0 Poxvirus DNA-directed RNA polymerase 19 kDa subunit DUF2115 PF09888.9 ETO36927.1 - 0.0018 18.8 3.5 0.0019 18.7 1.0 1.9 2 0 0 2 2 2 1 Uncharacterized protein conserved in archaea (DUF2115) DCP1 PF06058.13 ETO36927.1 - 0.0064 16.4 0.6 0.017 15.0 0.1 1.9 1 1 1 2 2 2 1 Dcp1-like decapping family FIVAR PF07554.13 ETO36927.1 - 0.02 15.7 2.0 0.02 15.7 2.0 2.3 2 0 0 2 2 2 0 FIVAR domain Pkinase PF00069.25 ETO36928.1 - 4e-05 23.1 0.0 4e-05 23.1 0.0 2.4 3 0 0 3 3 3 1 Protein kinase domain Pkinase PF00069.25 ETO36929.1 - 1.2e-17 64.1 0.3 2.1e-12 47.0 0.1 2.4 2 0 0 2 2 2 2 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36929.1 - 0.00023 20.6 0.1 0.00081 18.7 0.0 1.8 2 0 0 2 2 2 1 Protein tyrosine kinase CCDC-167 PF15188.6 ETO36929.1 - 0.00034 20.9 3.9 0.00051 20.3 0.8 2.4 1 1 1 2 2 2 1 Coiled-coil domain-containing protein 167 DUF1359 PF07097.11 ETO36929.1 - 0.0031 17.7 1.0 0.0066 16.7 0.8 1.7 1 1 0 1 1 1 1 Protein of unknown function (DUF1359) DUF1796 PF08795.10 ETO36929.1 - 0.048 13.6 1.1 0.097 12.6 0.3 1.9 2 0 0 2 2 2 0 Putative papain-like cysteine peptidase (DUF1796) DUF1090 PF06476.12 ETO36929.1 - 0.11 12.6 1.8 0.2 11.8 1.8 1.4 1 0 0 1 1 1 0 Protein of unknown function (DUF1090) FlxA PF14282.6 ETO36929.1 - 1.2 9.2 7.8 2.5 8.1 7.8 1.5 1 0 0 1 1 1 0 FlxA-like protein COG4 PF08318.12 ETO36932.1 - 0.0085 15.2 2.5 0.012 14.8 2.5 1.1 1 0 0 1 1 1 1 COG4 transport protein AIP3 PF03915.13 ETO36932.1 - 0.013 14.7 5.0 0.016 14.3 5.0 1.1 1 0 0 1 1 1 0 Actin interacting protein 3 CorA PF01544.18 ETO36932.1 - 0.18 11.1 0.5 0.28 10.5 0.5 1.3 1 0 0 1 1 1 0 CorA-like Mg2+ transporter protein SEEEED PF14797.6 ETO36932.1 - 0.57 10.3 5.9 0.95 9.6 5.9 1.3 1 0 0 1 1 1 0 Serine-rich region of AP3B1, clathrin-adaptor complex zf-CCHC_4 PF14392.6 ETO36932.1 - 1.3 8.9 8.5 0.79 9.5 0.4 2.5 2 0 0 2 2 2 0 Zinc knuckle DUF2992 PF11208.8 ETO36932.1 - 2.9 8.2 12.9 0.65 10.2 8.3 2.0 1 1 1 2 2 2 0 Protein of unknown function (DUF2992) WD40 PF00400.32 ETO36933.1 - 5.2e-12 46.1 4.6 1.1e-06 29.2 0.2 2.9 3 0 0 3 3 3 2 WD domain, G-beta repeat Nup160 PF11715.8 ETO36933.1 - 1.7e-06 27.0 0.7 0.021 13.5 0.0 2.4 2 1 1 3 3 3 2 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO36933.1 - 9.5e-05 22.6 0.1 0.14 12.4 0.0 2.8 2 2 1 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain DUF4784 PF16023.5 ETO36933.1 - 0.017 14.1 0.0 0.037 13.0 0.0 1.4 1 1 0 1 1 1 0 Domain of unknown function (DUF4784) Kelch_2 PF07646.15 ETO36934.1 - 1.2e-08 34.6 0.6 0.0068 16.3 0.1 4.7 5 0 0 5 5 5 2 Kelch motif Kelch_5 PF13854.6 ETO36934.1 - 1.7e-07 31.1 1.6 0.53 10.3 0.1 5.2 5 0 0 5 5 5 2 Kelch motif Kelch_1 PF01344.25 ETO36934.1 - 1.2e-05 24.8 0.4 0.026 14.1 0.2 3.8 4 0 0 4 4 4 2 Kelch motif Kelch_6 PF13964.6 ETO36934.1 - 3.3e-05 24.0 1.5 0.081 13.2 0.1 4.1 5 0 0 5 5 5 2 Kelch motif Kelch_4 PF13418.6 ETO36934.1 - 0.011 15.7 1.2 0.27 11.2 0.3 3.1 4 0 0 4 4 4 0 Galactose oxidase, central domain Kelch_4 PF13418.6 ETO36935.1 - 6.2e-06 26.1 2.6 2.3e-05 24.3 0.1 2.7 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO36935.1 - 9.9e-06 25.7 2.7 11 6.5 0.0 5.1 5 0 0 5 5 5 2 Kelch motif Kelch_2 PF07646.15 ETO36935.1 - 1.6e-05 24.6 1.7 0.022 14.7 0.2 4.4 5 0 0 5 5 5 1 Kelch motif Kelch_1 PF01344.25 ETO36935.1 - 0.00052 19.6 0.7 0.046 13.3 0.2 3.8 4 0 0 4 4 4 1 Kelch motif Kelch_3 PF13415.6 ETO36935.1 - 0.0084 16.4 0.1 3.7 7.9 0.0 3.8 5 0 0 5 5 5 1 Galactose oxidase, central domain Copper-bind PF00127.20 ETO36935.1 - 0.019 15.4 0.2 0.066 13.7 0.2 2.0 1 0 0 1 1 1 0 Copper binding proteins, plastocyanin/azurin family Kelch_5 PF13854.6 ETO36935.1 - 0.021 14.8 3.8 21 5.3 0.0 4.9 6 0 0 6 6 6 0 Kelch motif Peptidase_S10 PF00450.22 ETO36936.1 - 5.3e-28 98.6 0.2 6.4e-28 98.3 0.2 1.1 1 0 0 1 1 1 1 Serine carboxypeptidase Kelch_1 PF01344.25 ETO36937.1 - 2.6e-07 30.1 0.9 0.00085 18.9 0.2 4.0 4 0 0 4 4 4 2 Kelch motif Kelch_2 PF07646.15 ETO36937.1 - 6.3e-06 26.0 1.7 0.0067 16.4 0.2 3.3 3 0 0 3 3 3 2 Kelch motif Kelch_5 PF13854.6 ETO36937.1 - 1e-05 25.4 1.6 0.096 12.7 0.5 4.2 4 0 0 4 4 4 2 Kelch motif Kelch_4 PF13418.6 ETO36937.1 - 2e-05 24.5 1.8 0.0007 19.5 0.1 3.2 3 0 0 3 3 3 1 Galactose oxidase, central domain Kelch_6 PF13964.6 ETO36937.1 - 4.6e-05 23.5 1.4 0.2 12.0 0.0 3.9 3 0 0 3 3 3 2 Kelch motif Kelch_3 PF13415.6 ETO36937.1 - 0.019 15.2 0.0 0.18 12.1 0.0 2.6 2 0 0 2 2 2 0 Galactose oxidase, central domain rve PF00665.26 ETO36938.1 - 0.00024 21.3 0.0 0.0018 18.5 0.0 2.2 1 1 0 1 1 1 1 Integrase core domain RVT_1 PF00078.27 ETO36939.1 - 2.8e-24 85.9 0.1 6.7e-24 84.6 0.0 1.6 1 1 0 1 1 1 1 Reverse transcriptase (RNA-dependent DNA polymerase) DSPc PF00782.20 ETO36940.1 - 1.1e-19 70.5 0.6 1.5e-19 70.1 0.6 1.2 1 0 0 1 1 1 1 Dual specificity phosphatase, catalytic domain Init_tRNA_PT PF04179.12 ETO36940.1 - 0.013 15.8 0.2 0.025 14.9 0.1 1.5 1 1 0 1 1 1 0 Rit1 DUSP-like domain TFIIE_beta PF02186.15 ETO36940.1 - 0.11 12.8 0.8 0.7 10.2 0.1 2.4 3 0 0 3 3 3 0 TFIIE beta subunit core domain Kelch_6 PF13964.6 ETO36941.1 - 1.8e-07 31.2 0.5 0.63 10.4 0.1 4.1 4 0 0 4 4 4 3 Kelch motif Kelch_2 PF07646.15 ETO36941.1 - 4.1e-06 26.6 2.2 3.2 7.9 0.1 5.2 5 0 0 5 5 5 3 Kelch motif Kelch_1 PF01344.25 ETO36941.1 - 1.4e-05 24.6 1.0 0.017 14.7 0.3 4.0 4 0 0 4 4 4 1 Kelch motif Kelch_4 PF13418.6 ETO36941.1 - 1.4e-05 25.0 0.0 0.0065 16.4 0.0 2.6 2 0 0 2 2 2 2 Galactose oxidase, central domain Kelch_5 PF13854.6 ETO36941.1 - 0.0057 16.6 0.6 20 5.3 0.2 4.1 4 0 0 4 4 4 1 Kelch motif N_Asn_amidohyd PF14736.6 ETO36941.1 - 0.044 12.9 0.2 0.46 9.6 0.1 2.1 2 0 0 2 2 2 0 Protein N-terminal asparagine amidohydrolase TPR_17 PF13431.6 ETO36942.1 - 3.4e-10 39.6 0.5 0.03 14.7 0.0 6.1 5 0 0 5 5 5 2 Tetratricopeptide repeat TPR_8 PF13181.6 ETO36942.1 - 1.9e-08 33.9 1.0 0.039 14.2 0.1 6.9 8 0 0 8 8 8 2 Tetratricopeptide repeat TPR_1 PF00515.28 ETO36942.1 - 3e-07 30.0 0.1 1.9 8.5 0.0 6.4 6 0 0 6 6 6 2 Tetratricopeptide repeat TPR_2 PF07719.17 ETO36942.1 - 3.1e-07 30.0 4.3 0.85 9.9 0.1 7.2 8 1 1 9 9 8 2 Tetratricopeptide repeat TPR_19 PF14559.6 ETO36942.1 - 5.7e-07 29.9 0.1 0.0034 17.9 0.0 5.0 4 1 1 5 5 5 2 Tetratricopeptide repeat TPR_16 PF13432.6 ETO36942.1 - 0.014 16.0 1.0 1.2e+02 3.4 0.0 4.7 4 1 1 5 5 5 0 Tetratricopeptide repeat TPR_11 PF13414.6 ETO36942.1 - 0.021 14.5 0.1 22 4.8 0.0 4.4 3 2 2 5 5 5 0 TPR repeat TPR_14 PF13428.6 ETO36942.1 - 0.053 14.4 0.2 58 4.9 0.0 4.3 4 1 0 4 4 4 0 Tetratricopeptide repeat Protoglobin PF11563.8 ETO36942.1 - 0.12 12.3 0.0 0.39 10.6 0.0 1.8 2 0 0 2 2 2 0 Protoglobin TPR_9 PF13371.6 ETO36942.1 - 0.16 12.2 0.0 13 6.0 0.0 3.0 2 1 1 3 3 3 0 Tetratricopeptide repeat TPR_7 PF13176.6 ETO36942.1 - 0.22 11.7 1.2 31 4.9 0.0 3.9 4 0 0 4 4 4 0 Tetratricopeptide repeat Cofilin_ADF PF00241.20 ETO36944.1 - 7.3e-23 80.7 0.2 1.1e-22 80.1 0.2 1.3 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Dpy19 PF10034.9 ETO36945.1 - 0.00023 19.5 8.2 0.00054 18.3 2.2 2.1 1 1 1 2 2 2 2 Q-cell neuroblast polarisation Plasmodium_Vir PF05795.11 ETO36945.1 - 0.001 18.6 0.2 0.0012 18.3 0.2 1.2 1 0 0 1 1 1 1 Plasmodium vivax Vir protein DUF3270 PF11674.8 ETO36945.1 - 0.0059 16.8 3.5 0.0059 16.8 3.5 2.7 3 0 0 3 3 3 1 Protein of unknown function (DUF3270) LapA_dom PF06305.11 ETO36945.1 - 0.36 10.7 13.5 0.049 13.5 3.0 3.4 4 0 0 4 4 4 0 Lipopolysaccharide assembly protein A domain Orf78 PF06024.12 ETO36945.1 - 3.8 7.9 9.9 0.083 13.2 0.9 2.7 2 1 1 3 3 3 0 Orf78 (ac78) OAD_gamma PF04277.13 ETO36945.1 - 4.1 8.1 9.4 13 6.5 5.1 2.9 3 0 0 3 3 3 0 Oxaloacetate decarboxylase, gamma chain Clr2 PF10383.9 ETO36946.1 - 0.96 10.2 8.6 1.4 9.7 5.7 2.7 1 1 0 2 2 2 0 Transcription-silencing protein Clr2 KH_1 PF00013.29 ETO36948.1 - 2.2e-07 30.6 0.1 6.3e-05 22.7 0.0 2.2 2 0 0 2 2 2 2 KH domain WD40 PF00400.32 ETO36950.1 - 4.4e-16 59.0 12.1 3e-07 31.0 2.1 3.3 3 0 0 3 3 3 3 WD domain, G-beta repeat DDE_3 PF13358.6 ETO36950.1 - 1.3e-06 28.3 0.4 3.2e-06 27.0 0.4 1.8 1 1 0 1 1 1 1 DDE superfamily endonuclease Nup160 PF11715.8 ETO36950.1 - 0.0031 16.3 0.4 0.0098 14.6 0.4 1.7 1 1 0 1 1 1 1 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36950.1 - 0.014 14.8 0.8 0.73 9.1 0.3 2.0 1 1 1 2 2 2 0 WD40-like domain ANAPC4_WD40 PF12894.7 ETO36950.1 - 0.028 14.7 0.2 0.21 11.9 0.0 2.0 2 0 0 2 2 2 0 Anaphase-promoting complex subunit 4 WD40 domain Kelch_2 PF07646.15 ETO36950.1 - 0.1 12.6 1.0 5 7.3 0.2 2.9 2 1 0 2 2 2 0 Kelch motif DUF1899 PF08953.11 ETO36951.1 - 0.019 14.9 0.1 0.033 14.1 0.1 1.4 1 0 0 1 1 1 0 Domain of unknown function (DUF1899) His_Phos_1 PF00300.22 ETO36952.1 - 2.4e-05 24.1 0.0 3.1e-05 23.8 0.0 1.1 1 0 0 1 1 1 1 Histidine phosphatase superfamily (branch 1) ADH_N PF08240.12 ETO36953.1 - 5e-06 26.4 0.0 2.5e-05 24.1 0.0 2.0 1 1 1 2 2 2 1 Alcohol dehydrogenase GroES-like domain Metallophos PF00149.28 ETO36954.1 - 6.5e-35 121.5 0.0 8.8e-35 121.1 0.0 1.2 1 0 0 1 1 1 1 Calcineurin-like phosphoesterase Metallophos_2 PF12850.7 ETO36954.1 - 0.02 15.1 0.0 0.036 14.3 0.0 1.4 1 0 0 1 1 1 0 Calcineurin-like phosphoesterase superfamily domain STPPase_N PF16891.5 ETO36954.1 - 0.1 13.0 0.2 0.1 13.0 0.2 2.0 2 0 0 2 2 2 0 Serine-threonine protein phosphatase N-terminal domain CENP-F_leu_zip PF10473.9 ETO36955.1 - 0.0022 18.0 8.6 0.0032 17.5 8.6 1.2 1 0 0 1 1 1 1 Leucine-rich repeats of kinetochore protein Cenp-F/LEK1 FapA PF03961.13 ETO36955.1 - 0.014 14.0 2.8 0.014 14.0 2.8 1.1 1 0 0 1 1 1 0 Flagellar Assembly Protein A Pox_A22 PF04848.13 ETO36955.1 - 0.018 15.1 4.5 1.1 9.4 0.3 2.1 1 1 1 2 2 2 0 Poxvirus A22 protein HBM PF16591.5 ETO36955.1 - 0.022 14.2 3.0 0.035 13.6 3.0 1.2 1 0 0 1 1 1 0 Helical bimodular sensor domain DivIC PF04977.15 ETO36955.1 - 0.029 14.1 6.2 0.41 10.5 2.5 2.5 2 0 0 2 2 2 0 Septum formation initiator BLOC1_2 PF10046.9 ETO36955.1 - 0.03 14.6 7.6 0.13 12.6 3.1 2.2 1 1 1 2 2 2 0 Biogenesis of lysosome-related organelles complex-1 subunit 2 Mito_fiss_reg PF05308.11 ETO36955.1 - 0.051 13.7 2.8 0.14 12.2 2.8 1.5 1 1 0 1 1 1 0 Mitochondrial fission regulator RVT_connect PF06815.13 ETO36955.1 - 0.06 13.6 0.2 0.09 13.0 0.2 1.4 1 0 0 1 1 1 0 Reverse transcriptase connection domain APG6_N PF17675.1 ETO36955.1 - 0.1 13.1 10.0 0.16 12.5 10.0 1.4 1 1 0 1 1 1 0 Apg6 coiled-coil region TMEM191C PF15194.6 ETO36955.1 - 0.13 12.5 0.1 0.2 11.8 0.1 1.3 1 0 0 1 1 1 0 TMEM191C family CENP-Q PF13094.6 ETO36955.1 - 0.13 12.5 9.7 0.29 11.3 9.4 1.5 1 1 1 2 2 2 0 CENP-Q, a CENPA-CAD centromere complex subunit ZapB PF06005.12 ETO36955.1 - 0.23 11.9 12.5 0.2 12.1 5.7 2.2 1 1 1 2 2 2 0 Cell division protein ZapB DHR10 PF18595.1 ETO36955.1 - 0.28 11.3 11.5 0.97 9.5 11.5 1.7 1 1 0 1 1 1 0 Designed helical repeat protein 10 domain DUF16 PF01519.16 ETO36955.1 - 0.59 10.7 5.2 2 8.9 5.2 1.8 1 1 0 1 1 1 0 Protein of unknown function DUF16 FlaC_arch PF05377.11 ETO36955.1 - 0.95 9.9 5.8 47 4.5 5.7 2.5 1 1 0 1 1 1 0 Flagella accessory protein C (FlaC) TMF_DNA_bd PF12329.8 ETO36955.1 - 3.3 7.8 12.2 4.3 7.4 6.3 2.2 2 0 0 2 2 2 0 TATA element modulatory factor 1 DNA binding M PF02370.16 ETO36955.1 - 5.2 8.0 9.0 4.3 8.2 2.1 3.3 2 1 0 2 2 2 0 M protein repeat bZIP_1 PF00170.21 ETO36955.1 - 7.9 6.7 10.4 3.2 7.9 3.3 2.5 1 1 1 2 2 2 0 bZIP transcription factor Hydrolase_4 PF12146.8 ETO36956.1 - 0.034 13.4 0.0 0.5 9.6 0.0 2.2 2 0 0 2 2 2 0 Serine aminopeptidase, S33 WD40 PF00400.32 ETO36957.1 - 1.6e-15 57.2 11.3 0.0016 19.2 0.5 5.6 6 0 0 6 6 6 4 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36957.1 - 1.9e-10 40.9 0.4 0.42 11.0 0.0 5.2 2 1 3 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain eIF2A PF08662.11 ETO36957.1 - 0.0011 18.9 1.0 0.25 11.2 0.4 2.8 2 1 1 3 3 3 2 Eukaryotic translation initiation factor eIF2A Frtz PF11768.8 ETO36957.1 - 0.017 13.5 0.1 0.67 8.2 0.0 2.1 2 0 0 2 2 2 0 WD repeat-containing and planar cell polarity effector protein Fritz Pkinase PF00069.25 ETO36958.1 - 1.8e-37 129.1 0.0 2.4e-37 128.8 0.0 1.1 1 0 0 1 1 1 1 Protein kinase domain Pkinase_Tyr PF07714.17 ETO36958.1 - 6.1e-13 48.7 0.0 8.6e-13 48.2 0.0 1.2 1 0 0 1 1 1 1 Protein tyrosine kinase PEPcase PF00311.17 ETO36958.1 - 0.00034 18.8 0.3 0.00045 18.4 0.3 1.0 1 0 0 1 1 1 1 Phosphoenolpyruvate carboxylase Kinase-like PF14531.6 ETO36958.1 - 0.00078 18.8 0.0 0.0011 18.3 0.0 1.3 1 1 0 1 1 1 1 Kinase-like G-alpha PF00503.20 ETO36959.1 - 1.4e-50 172.5 0.2 1.6e-50 172.3 0.2 1.0 1 0 0 1 1 1 1 G-protein alpha subunit Arf PF00025.21 ETO36959.1 - 1.5e-07 31.0 2.1 0.0002 20.8 0.1 2.8 2 1 1 3 3 3 2 ADP-ribosylation factor family Mg_chelatase PF01078.21 ETO36959.1 - 0.0084 15.5 0.0 0.013 14.8 0.0 1.3 1 0 0 1 1 1 1 Magnesium chelatase, subunit ChlI FtsK_SpoIIIE PF01580.18 ETO36959.1 - 0.0092 15.4 0.0 0.015 14.7 0.0 1.2 1 0 0 1 1 1 1 FtsK/SpoIIIE family ABC_tran PF00005.27 ETO36959.1 - 0.01 16.3 0.1 0.02 15.4 0.1 1.4 1 0 0 1 1 1 0 ABC transporter AAA_16 PF13191.6 ETO36959.1 - 0.011 16.1 0.0 0.014 15.8 0.0 1.2 1 0 0 1 1 1 0 AAA ATPase domain Roc PF08477.13 ETO36959.1 - 0.016 15.5 0.3 0.67 10.2 0.1 2.3 2 0 0 2 2 2 0 Ras of Complex, Roc, domain of DAPkinase AAA_29 PF13555.6 ETO36959.1 - 0.021 14.6 0.1 0.039 13.7 0.1 1.4 1 0 0 1 1 1 0 P-loop containing region of AAA domain NB-ARC PF00931.22 ETO36959.1 - 0.091 11.9 0.2 0.14 11.3 0.2 1.2 1 0 0 1 1 1 0 NB-ARC domain MMR_HSR1 PF01926.23 ETO36959.1 - 0.2 11.8 0.3 3.7 7.6 0.1 2.3 2 1 0 2 2 2 0 50S ribosome-binding GTPase EIIBC-GUT_N PF03612.14 ETO36960.1 - 0.011 15.5 5.3 0.012 15.4 5.3 1.1 1 0 0 1 1 1 0 Sorbitol phosphotransferase enzyme II N-terminus DUF1676 PF07898.13 ETO36963.1 - 0.013 15.6 1.5 0.049 13.7 0.0 2.0 2 0 0 2 2 2 0 Protein of unknown function (DUF1676) DUF4834 PF16118.5 ETO36963.1 - 3 8.9 7.0 2.5 9.1 4.5 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4834) Ipi1_N PF12333.8 ETO36964.1 - 0.13 12.9 0.2 13 6.5 0.0 2.3 2 0 0 2 2 2 0 Rix1 complex component involved in 60S ribosome maturation SNARE PF05739.19 ETO36965.1 - 1.6e-09 37.6 3.9 2.3e-09 37.1 0.3 2.2 1 1 1 2 2 2 1 SNARE domain Use1 PF09753.9 ETO36965.1 - 0.004 16.9 2.0 0.0048 16.6 2.0 1.2 1 0 0 1 1 1 1 Membrane fusion protein Use1 Tweety PF04906.13 ETO36965.1 - 0.025 13.3 0.5 0.028 13.1 0.5 1.0 1 0 0 1 1 1 0 Tweety B PF02216.16 ETO36965.1 - 0.041 13.9 0.4 0.1 12.6 0.4 1.7 2 0 0 2 2 2 0 B domain Tox-REase-9 PF15650.6 ETO36965.1 - 0.16 12.3 0.1 0.22 11.8 0.1 1.1 1 0 0 1 1 1 0 Restriction endonuclease fold toxin 9 Proteasome PF00227.26 ETO36967.1 - 1.3e-13 50.8 1.9 1.9e-12 47.1 1.9 2.2 1 1 0 1 1 1 1 Proteasome subunit ENTH PF01417.20 ETO36969.1 - 6.6e-34 116.6 0.2 1.8e-33 115.2 0.2 1.7 1 1 0 1 1 1 1 ENTH domain ANTH PF07651.16 ETO36969.1 - 6.9e-05 22.0 0.1 0.00016 20.8 0.0 1.6 2 0 0 2 2 2 1 ANTH domain Prok-RING_4 PF14447.6 ETO36970.1 - 0.55 10.1 9.6 1.3 8.9 9.6 1.7 1 0 0 1 1 1 0 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETO36970.1 - 5.4 7.0 20.7 0.034 14.0 12.0 1.9 2 0 0 2 2 2 0 Zinc finger, C3HC4 type (RING finger) UBX PF00789.20 ETO36971.1 - 2.1e-11 43.8 0.0 4.7e-11 42.7 0.0 1.6 1 0 0 1 1 1 1 UBX domain Aldedh PF00171.22 ETO36972.1 - 7.8e-58 196.1 0.1 1.4e-56 191.9 0.1 1.9 1 1 0 1 1 1 1 Aldehyde dehydrogenase family Beach PF02138.18 ETO36973.1 - 2.8e-24 86.0 0.1 4.7e-24 85.2 0.1 1.4 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 ETO36973.1 - 6.3e-10 39.5 0.2 0.0042 17.9 0.0 5.1 5 0 0 5 5 5 2 WD domain, G-beta repeat Sporozoite_P67 PF05642.11 ETO36973.1 - 0.13 10.3 3.2 0.18 9.8 3.2 1.2 1 0 0 1 1 1 0 Sporozoite P67 surface antigen FAM176 PF14851.6 ETO36973.1 - 0.15 11.7 3.5 0.3 10.8 3.5 1.4 1 0 0 1 1 1 0 FAM176 family Pox_Ag35 PF03286.14 ETO36973.1 - 0.22 11.3 5.4 0.59 9.9 3.2 2.2 2 0 0 2 2 2 0 Pox virus Ag35 surface protein DUF2457 PF10446.9 ETO36973.1 - 0.27 10.3 11.8 0.42 9.7 11.8 1.2 1 0 0 1 1 1 0 Protein of unknown function (DUF2457) Cwf_Cwc_15 PF04889.12 ETO36973.1 - 1.8 8.2 13.9 3.1 7.5 13.9 1.3 1 0 0 1 1 1 0 Cwf15/Cwc15 cell cycle control protein DUF3245 PF11595.8 ETO36973.1 - 4.3 7.8 10.9 7.8 7.0 10.9 1.3 1 0 0 1 1 1 0 Protein of unknown function (DUF3245) RRN3 PF05327.11 ETO36973.1 - 5.6 5.4 8.4 8.4 4.8 8.4 1.1 1 0 0 1 1 1 0 RNA polymerase I specific transcription initiation factor RRN3 DNA_pol_phi PF04931.13 ETO36973.1 - 6.1 4.8 11.7 7.9 4.4 11.7 1.1 1 0 0 1 1 1 0 DNA polymerase phi WD40 PF00400.32 ETO36974.1 - 8.6e-44 146.7 24.5 9.2e-08 32.6 2.3 7.3 7 0 0 7 7 7 6 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO36974.1 - 2.7e-15 56.4 0.3 0.00087 19.5 0.0 5.4 5 0 0 5 5 5 4 Anaphase-promoting complex subunit 4 WD40 domain Nup160 PF11715.8 ETO36974.1 - 1.6e-09 37.0 4.9 0.018 13.7 0.1 4.7 2 1 2 4 4 4 3 Nucleoporin Nup120/160 WD40_like PF17005.5 ETO36974.1 - 0.00034 20.1 1.8 2.2 7.5 0.0 4.3 2 1 3 5 5 5 2 WD40-like domain zf-C3HC4_2 PF13923.6 ETO36974.1 - 3.2 7.7 9.0 2.4 8.0 2.1 3.7 3 1 0 3 3 3 0 Zinc finger, C3HC4 type (RING finger) zf-RING-like PF08746.11 ETO36974.1 - 5.5 7.4 9.1 0.38 11.1 0.4 3.5 3 1 1 4 4 4 0 RING-like domain PTAC PF06130.12 ETO36975.1 - 0.14 12.4 0.0 0.24 11.6 0.0 1.3 1 0 0 1 1 1 0 Phosphate propanoyltransferase LicD PF04991.13 ETO36976.1 - 3.6e-06 27.3 4.2 9.3e-06 25.9 4.2 1.9 1 1 0 1 1 1 1 LicD family Mitofilin PF09731.9 ETO36977.1 - 2.7 6.7 21.7 2.8 6.7 21.7 1.0 1 0 0 1 1 1 0 Mitochondrial inner membrane protein PH PF00169.29 ETO36980.1 - 2e-14 54.0 4.7 6.1e-14 52.4 4.7 1.9 1 1 0 1 1 1 1 PH domain PH_8 PF15409.6 ETO36980.1 - 6.1e-08 32.8 1.2 1.4e-07 31.7 1.2 1.6 1 0 0 1 1 1 1 Pleckstrin homology domain PH_11 PF15413.6 ETO36980.1 - 1.6e-06 28.5 16.6 1.6e-05 25.3 1.9 3.4 2 1 2 4 4 4 2 Pleckstrin homology domain PH_3 PF14593.6 ETO36980.1 - 5.9e-06 26.3 0.9 1.5e-05 25.0 0.9 1.7 1 0 0 1 1 1 1 PH domain PH_6 PF15406.6 ETO36980.1 - 0.00028 21.1 0.7 0.00072 19.8 0.3 2.0 1 1 0 1 1 1 1 Pleckstrin homology domain PH_2 PF08458.10 ETO36980.1 - 0.0037 17.6 0.2 0.0085 16.4 0.2 1.7 1 0 0 1 1 1 1 Plant pleckstrin homology-like region Asp PF00026.23 ETO36981.1 - 5e-05 22.9 0.6 7e-05 22.4 0.1 1.5 2 0 0 2 2 2 1 Eukaryotic aspartyl protease ubiquitin PF00240.23 ETO36982.1 - 3.6e-18 65.1 5.0 2.1e-12 46.6 0.4 3.1 2 1 0 2 2 2 2 Ubiquitin family Rad60-SLD PF11976.8 ETO36982.1 - 9.1e-09 35.0 1.6 6.4e-06 25.9 0.2 3.1 2 2 0 2 2 2 2 Ubiquitin-2 like Rad60 SUMO-like Ubiquitin_2 PF14560.6 ETO36982.1 - 0.047 14.1 0.2 0.57 10.7 0.1 2.6 2 1 0 2 2 2 0 Ubiquitin-like domain Ubiquitin_4 PF18036.1 ETO36982.1 - 0.051 13.6 1.7 7.6 6.7 0.0 3.1 2 1 1 3 3 3 0 Ubiquitin-like domain CGGC PF08821.11 ETO36982.1 - 0.056 13.6 0.0 0.1 12.8 0.0 1.4 1 0 0 1 1 1 0 CGGC domain Dus PF01207.17 ETO36983.1 - 7.5e-30 104.1 0.0 9.1e-30 103.8 0.0 1.1 1 0 0 1 1 1 1 Dihydrouridine synthase (Dus) DUF2237 PF09996.9 ETO36984.1 - 0.1 12.6 0.0 0.22 11.5 0.0 1.5 1 0 0 1 1 1 0 Uncharacterized protein conserved in bacteria (DUF2237) SPRY PF00622.28 ETO36985.1 - 0.0027 17.8 1.5 0.0054 16.8 0.4 2.1 2 0 0 2 2 2 1 SPRY domain PQ-loop PF04193.14 ETO36987.1 - 9.5e-19 66.9 13.9 3.8e-11 42.6 3.3 2.9 3 0 0 3 3 3 2 PQ loop repeat EKAL PF17986.1 ETO36987.1 - 0.0091 16.0 0.5 0.017 15.2 0.5 1.4 1 0 0 1 1 1 1 EMP3-KAHRP-like N-terminal domain zf-C2H2_6 PF13912.6 ETO36988.1 - 0.0024 17.8 0.5 0.0024 17.8 0.5 2.5 2 0 0 2 2 2 1 C2H2-type zinc finger zf-C2H2 PF00096.26 ETO36988.1 - 0.0055 17.1 0.3 0.0055 17.1 0.3 3.0 3 0 0 3 3 3 1 Zinc finger, C2H2 type zf-met PF12874.7 ETO36988.1 - 0.015 15.7 1.2 0.085 13.3 0.2 2.8 2 0 0 2 2 2 0 Zinc-finger of C2H2 type zf-BED PF02892.15 ETO36988.1 - 0.061 13.4 7.9 1.1 9.3 2.0 3.3 1 1 1 2 2 2 0 BED zinc finger zf-C2H2_4 PF13894.6 ETO36988.1 - 0.098 13.5 5.6 0.11 13.4 0.3 3.2 3 0 0 3 3 3 0 C2H2-type zinc finger zf-H2C2_2 PF13465.6 ETO36988.1 - 0.14 12.7 7.8 4.6 7.8 0.3 3.1 2 0 0 2 2 2 0 Zinc-finger double domain Pox_E10 PF04805.12 ETO36988.1 - 0.65 9.9 7.6 0.78 9.7 1.5 3.2 3 0 0 3 3 3 0 E10-like protein conserved region ABC1 PF03109.16 ETO36989.1 - 1.6e-17 63.7 0.5 4.2e-10 39.8 0.1 2.4 2 0 0 2 2 2 2 ABC1 family APH PF01636.23 ETO36990.1 - 0.017 15.0 0.1 0.035 14.0 0.1 1.4 1 0 0 1 1 1 0 Phosphotransferase enzyme family Cation_efflux PF01545.21 ETO36992.1 - 1.8e-24 86.6 10.3 2.3e-24 86.2 10.3 1.1 1 0 0 1 1 1 1 Cation efflux family Thiol_cytolys_C PF17440.2 ETO36992.1 - 0.14 12.4 0.0 0.19 11.9 0.0 1.5 1 1 0 1 1 1 0 Thiol-activated cytolysin beta sandwich domain RseC_MucC PF04246.12 ETO36992.1 - 0.93 9.5 3.9 0.31 11.0 0.3 1.9 1 1 1 2 2 2 0 Positive regulator of sigma(E), RseC/MucC Amino_oxidase PF01593.24 ETO36993.1 - 1.9e-11 43.9 0.0 2.3e-11 43.7 0.0 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase NAD_binding_8 PF13450.6 ETO36993.1 - 1.6e-05 25.0 0.0 3.4e-05 24.0 0.0 1.6 1 0 0 1 1 1 1 NAD(P)-binding Rossmann-like domain FAD_binding_2 PF00890.24 ETO36993.1 - 5.9e-05 22.3 0.4 7.4e-05 22.0 0.3 1.4 1 1 0 1 1 1 1 FAD binding domain Pyr_redox_2 PF07992.14 ETO36993.1 - 0.00041 19.7 0.1 0.00093 18.5 0.1 1.6 1 1 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase DAO PF01266.24 ETO36993.1 - 0.00041 20.0 1.4 0.0015 18.1 0.9 1.8 1 1 1 2 2 2 1 FAD dependent oxidoreductase Thi4 PF01946.17 ETO36993.1 - 0.0043 16.3 0.0 0.0084 15.4 0.0 1.4 1 0 0 1 1 1 1 Thi4 family GIDA PF01134.22 ETO36993.1 - 0.0046 16.1 0.1 0.01 15.0 0.0 1.6 2 0 0 2 2 2 1 Glucose inhibited division protein A FAD_binding_3 PF01494.19 ETO36993.1 - 0.0069 15.7 0.2 0.012 14.9 0.2 1.3 1 0 0 1 1 1 1 FAD binding domain Pyr_redox_3 PF13738.6 ETO36993.1 - 0.01 15.1 0.2 0.026 13.8 0.2 1.7 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase AbiEi_3_N PF17194.4 ETO36993.1 - 0.049 13.7 0.1 1.2 9.2 0.0 2.4 2 0 0 2 2 2 0 Transcriptional regulator, AbiEi antitoxin N-terminal domain FAD_oxidored PF12831.7 ETO36993.1 - 0.06 12.7 0.5 0.1 11.9 0.2 1.5 1 1 0 1 1 1 0 FAD dependent oxidoreductase Pyr_redox PF00070.27 ETO36993.1 - 0.068 13.7 0.2 0.15 12.6 0.2 1.6 1 0 0 1 1 1 0 Pyridine nucleotide-disulphide oxidoreductase Amino_oxidase PF01593.24 ETO36994.1 - 1.4e-09 37.8 0.0 1.6e-09 37.6 0.0 1.0 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase Amino_oxidase PF01593.24 ETO36995.1 - 6.6e-05 22.4 0.2 8.7e-05 22.0 0.2 1.2 1 0 0 1 1 1 1 Flavin containing amine oxidoreductase HEPN_Apea PF18739.1 ETO36996.1 - 0.055 13.9 0.7 0.25 11.8 0.7 2.1 1 0 0 1 1 1 0 Apea-like HEPN RPAP3_C PF13877.6 ETO36996.1 - 0.12 12.9 1.5 0.32 11.5 0.6 2.2 2 0 0 2 2 2 0 Potential Monad-binding region of RPAP3 PUB PF09409.10 ETO36997.1 - 0.00044 20.1 1.0 0.00092 19.1 0.4 1.9 2 1 0 2 2 2 1 PUB domain BORCS6 PF10157.9 ETO36997.1 - 0.02 15.1 0.1 0.038 14.2 0.1 1.5 1 0 0 1 1 1 0 BLOC-1-related complex sub-unit 6 UTP15_C PF09384.10 ETO36997.1 - 0.029 14.0 0.0 0.085 12.5 0.0 1.7 2 0 0 2 2 2 0 UTP15 C terminal NPM1-C PF16276.5 ETO36997.1 - 2.1 8.3 5.4 2.9 7.9 1.5 2.5 2 0 0 2 2 2 0 Nucleophosmin C-terminal domain ATG_C PF09333.11 ETO36998.1 - 1.1e-21 77.0 0.1 5.4e-21 74.8 0.0 2.1 2 0 0 2 2 2 1 Autophagy-related protein C terminal domain VPS13_C PF16909.5 ETO36998.1 - 0.0011 18.7 0.3 0.0054 16.5 0.1 2.0 2 0 0 2 2 2 1 Vacuolar-sorting-associated 13 protein C-terminal AIPR PF10592.9 ETO36998.1 - 0.0043 16.7 0.6 0.0084 15.8 0.6 1.4 1 0 0 1 1 1 1 AIPR protein Pox_Ag35 PF03286.14 ETO36999.1 - 0.021 14.6 1.4 0.021 14.6 1.4 1.8 2 0 0 2 2 2 0 Pox virus Ag35 surface protein Radial_spoke PF04712.12 ETO36999.1 - 1.6 7.6 11.5 2 7.3 11.0 1.3 1 1 0 1 1 1 0 Radial spokehead-like protein Drf_GBD PF06371.13 ETO36999.1 - 3.5 7.1 7.2 1.1 8.8 0.4 2.2 2 0 0 2 2 2 0 Diaphanous GTPase-binding Domain Na_trans_assoc PF06512.13 ETO36999.1 - 8.7 6.6 11.2 22 5.2 11.5 1.4 1 1 0 1 1 1 0 Sodium ion transport-associated zf-TRAF PF02176.18 ETO37001.1 - 4.6e-06 27.2 1.6 4.6e-06 27.2 1.6 2.8 3 1 0 3 3 3 1 TRAF-type zinc finger zf-MIZ PF02891.20 ETO37001.1 - 6.4 6.6 9.2 0.22 11.3 1.4 2.6 3 0 0 3 3 3 0 MIZ/SP-RING zinc finger Ribosomal_L7Ae PF01248.26 ETO37002.1 - 1.1e-10 41.1 0.4 3.8e-10 39.4 0.2 1.9 1 1 1 2 2 2 1 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family WD40 PF00400.32 ETO37005.1 - 2.9e-14 53.2 13.0 0.0019 19.0 0.1 5.5 5 1 0 5 5 5 3 WD domain, G-beta repeat Nup160 PF11715.8 ETO37005.1 - 0.0003 19.6 3.9 0.18 10.4 0.1 3.2 2 2 1 3 3 3 3 Nucleoporin Nup120/160 ANAPC4_WD40 PF12894.7 ETO37005.1 - 0.0017 18.6 1.1 3.1 8.2 0.0 3.7 2 1 2 4 4 4 2 Anaphase-promoting complex subunit 4 WD40 domain Trypsin_2 PF13365.6 ETO37006.1 - 1.2e-12 49.0 0.0 2.9e-10 41.2 0.0 3.0 2 1 0 2 2 2 1 Trypsin-like peptidase domain PDZ_6 PF17820.1 ETO37006.1 - 5.7e-11 42.1 0.1 6.7e-05 22.7 0.0 4.3 5 0 0 5 5 5 2 PDZ domain PDZ_2 PF13180.6 ETO37006.1 - 2.5e-09 37.3 0.1 3.8e-05 23.9 0.2 3.0 3 0 0 3 3 3 2 PDZ domain PDZ PF00595.24 ETO37006.1 - 4e-05 23.9 0.3 0.15 12.4 0.3 3.5 3 0 0 3 3 3 2 PDZ domain SspB PF04386.13 ETO37007.1 - 0.1 12.5 0.6 0.2 11.5 0.6 1.4 1 0 0 1 1 1 0 Stringent starvation protein B RasGEF PF00617.19 ETO37008.1 - 9.5e-53 179.0 2.0 9.5e-53 179.0 2.0 2.0 2 0 0 2 2 2 1 RasGEF domain RasGEF_N PF00618.20 ETO37008.1 - 8.5e-11 42.0 3.3 1.2e-10 41.5 1.1 2.5 2 0 0 2 2 2 1 RasGEF N-terminal motif PUB PF09409.10 ETO37008.1 - 1.5e-07 31.2 0.0 4e-07 29.9 0.0 1.7 1 0 0 1 1 1 1 PUB domain DUF4220 PF13968.6 ETO37008.1 - 0.18 11.2 2.7 0.16 11.3 0.3 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF4220) Med1 PF10744.9 ETO37009.1 - 0.091 11.8 0.0 0.13 11.3 0.0 1.3 1 0 0 1 1 1 0 Mediator of RNA polymerase II transcription subunit 1 Cyt-b5 PF00173.28 ETO37011.1 - 1.1e-11 44.7 0.1 2e-11 43.9 0.1 1.4 1 0 0 1 1 1 1 Cytochrome b5-like Heme/Steroid binding domain Cofilin_ADF PF00241.20 ETO37012.1 - 1.1e-09 38.2 0.0 2.2e-09 37.1 0.0 1.5 1 0 0 1 1 1 1 Cofilin/tropomyosin-type actin-binding protein Mucin PF01456.17 ETO37012.1 - 0.011 15.7 3.8 0.016 15.2 3.8 1.1 1 0 0 1 1 1 0 Mucin-like glycoprotein Raftlin PF15250.6 ETO37012.1 - 0.024 13.4 1.4 0.03 13.1 1.4 1.1 1 0 0 1 1 1 0 Raftlin Mitofilin PF09731.9 ETO37012.1 - 0.059 12.2 6.1 0.074 11.9 6.1 1.1 1 0 0 1 1 1 0 Mitochondrial inner membrane protein Presenilin PF01080.17 ETO37012.1 - 0.087 11.6 2.5 0.11 11.2 2.5 1.1 1 0 0 1 1 1 0 Presenilin DUF908 PF06012.12 ETO37012.1 - 0.097 12.1 1.9 0.11 11.9 1.9 1.1 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) Hid1 PF12722.7 ETO37012.1 - 0.19 9.8 3.2 0.24 9.5 3.2 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein Suf PF05843.14 ETO37012.1 - 0.32 10.9 3.7 0.41 10.6 3.7 1.2 1 0 0 1 1 1 0 Suppressor of forked protein (Suf) TP53IP5 PF15331.6 ETO37012.1 - 0.36 11.0 3.6 0.49 10.5 3.6 1.2 1 0 0 1 1 1 0 Cellular tumour antigen p53-inducible 5 DUF4820 PF16091.5 ETO37012.1 - 0.37 10.1 3.5 0.53 9.6 3.5 1.2 1 0 0 1 1 1 0 Domain of unknown function (DUF4820) RR_TM4-6 PF06459.12 ETO37012.1 - 8.8 6.1 10.7 13 5.5 10.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Red1 PF07964.11 ETO37012.1 - 9.1 4.4 15.0 4.3 5.4 12.7 1.4 2 0 0 2 2 2 0 Rec10 / Red1 Sacchrp_dh_NADP PF03435.18 ETO37013.1 - 3.1e-14 53.4 0.0 3.6e-14 53.1 0.0 1.0 1 0 0 1 1 1 1 Saccharopine dehydrogenase NADP binding domain Cytomega_UL84 PF06284.11 ETO37013.1 - 0.025 13.0 0.7 0.025 13.1 0.7 1.0 1 0 0 1 1 1 0 Cytomegalovirus UL84 protein adh_short_C2 PF13561.6 ETO37013.1 - 0.056 13.0 0.1 0.065 12.8 0.1 1.2 1 0 0 1 1 1 0 Enoyl-(Acyl carrier protein) reductase zf-RING_2 PF13639.6 ETO37014.1 - 1.9e-11 44.1 4.3 1.9e-11 44.1 4.3 1.9 1 1 1 2 2 2 1 Ring finger domain zf-rbx1 PF12678.7 ETO37014.1 - 1.4e-09 38.1 9.2 6.2e-09 36.0 9.2 2.3 1 1 0 1 1 1 1 RING-H2 zinc finger domain zf-C3HC4 PF00097.25 ETO37014.1 - 9.2e-08 31.8 4.0 9.2e-08 31.8 4.0 2.1 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-ANAPC11 PF12861.7 ETO37014.1 - 1.6e-06 28.1 3.6 1.6e-06 28.1 3.6 1.8 2 0 0 2 2 2 1 Anaphase-promoting complex subunit 11 RING-H2 finger zf-C3HC4_2 PF13923.6 ETO37014.1 - 2.5e-06 27.2 10.5 3.9e-06 26.6 7.8 2.5 1 1 0 1 1 1 1 Zinc finger, C3HC4 type (RING finger) zf-RING_5 PF14634.6 ETO37014.1 - 3.5e-06 26.9 7.8 6.7e-06 26.0 7.0 1.9 1 1 0 1 1 1 1 zinc-RING finger domain zf-RING_UBOX PF13445.6 ETO37014.1 - 5.6e-05 23.1 2.2 0.00017 21.5 2.2 1.9 1 0 0 1 1 1 1 RING-type zinc-finger Prok-RING_4 PF14447.6 ETO37014.1 - 0.00023 21.0 5.0 0.00023 21.0 5.0 2.2 1 1 1 2 2 2 1 Prokaryotic RING finger family 4 zf-C3HC4_3 PF13920.6 ETO37014.1 - 0.00049 19.9 10.9 0.00073 19.3 7.5 2.5 2 1 1 3 3 3 1 Zinc finger, C3HC4 type (RING finger) zf-RING_11 PF17123.5 ETO37014.1 - 0.0014 18.4 6.5 0.0037 17.0 3.8 2.7 2 1 0 2 2 2 1 RING-like zinc finger FANCL_C PF11793.8 ETO37014.1 - 0.049 13.8 5.6 0.32 11.2 5.6 2.3 1 1 0 1 1 1 0 FANCL C-terminal domain UBZ_FAAP20 PF15750.5 ETO37014.1 - 0.78 9.7 3.9 18 5.4 0.1 2.9 2 0 0 2 2 2 0 Ubiquitin-binding zinc-finger Zn_ribbon_17 PF17120.5 ETO37014.1 - 1 9.0 12.5 0.92 9.2 8.4 2.5 2 1 1 3 3 2 0 Zinc-ribbon, C4HC2 type zf-RING-like PF08746.11 ETO37014.1 - 2.3 8.6 9.7 0.47 10.8 0.5 2.5 2 0 0 2 2 2 0 RING-like domain zf-SNAP50_C PF12251.8 ETO37015.1 - 8.8e-72 241.0 8.8 1.2e-71 240.5 8.8 1.2 1 0 0 1 1 1 1 snRNA-activating protein of 50kDa MW C terminal zf-Dof PF02701.15 ETO37015.1 - 4.4 7.5 6.7 9.3 6.5 6.7 1.5 1 0 0 1 1 1 0 Dof domain, zinc finger MMR_HSR1_Xtn PF16897.5 ETO37016.1 - 0.097 12.7 1.3 0.2 11.7 0.9 1.9 1 1 1 2 2 2 0 C-terminal region of MMR_HSR1 domain Nop14 PF04147.12 ETO37018.1 - 0.65 8.1 24.5 0.8 7.8 24.5 1.1 1 0 0 1 1 1 0 Nop14-like family Presenilin PF01080.17 ETO37018.1 - 2.5 6.8 13.7 2.9 6.6 13.7 1.3 1 0 0 1 1 1 0 Presenilin Hid1 PF12722.7 ETO37018.1 - 3.1 5.8 15.4 3.4 5.7 15.4 1.1 1 0 0 1 1 1 0 High-temperature-induced dauer-formation protein PI3K_1B_p101 PF10486.9 ETO37018.1 - 5.6 4.6 14.1 6.3 4.4 14.1 1.1 1 0 0 1 1 1 0 Phosphoinositide 3-kinase gamma adapter protein p101 subunit Aldo_ket_red PF00248.21 ETO37019.1 - 1.9e-23 83.1 0.0 1.9e-19 70.0 0.0 2.0 2 0 0 2 2 2 2 Aldo/keto reductase family Aldo_ket_red PF00248.21 ETO37020.1 - 7.3e-20 71.3 0.0 8.9e-20 71.1 0.0 1.0 1 0 0 1 1 1 1 Aldo/keto reductase family MCU PF04678.13 ETO37021.1 - 0.017 15.3 4.2 0.027 14.6 4.2 1.3 1 0 0 1 1 1 0 Mitochondrial calcium uniporter CDC45 PF02724.14 ETO37021.1 - 0.14 10.5 7.0 0.17 10.1 7.0 1.0 1 0 0 1 1 1 0 CDC45-like protein vATP-synt_E PF01991.18 ETO37021.1 - 0.14 11.6 10.2 0.23 10.9 10.2 1.5 1 1 0 1 1 1 0 ATP synthase (E/31 kDa) subunit DUF21 PF01595.20 ETO37021.1 - 0.18 11.5 0.1 0.18 11.5 0.1 1.5 2 0 0 2 2 2 0 Cyclin M transmembrane N-terminal domain CHDCT2 PF08074.11 ETO37021.1 - 0.67 10.1 7.1 0.59 10.3 3.8 2.0 1 1 1 2 2 2 0 CHDCT2 (NUC038) domain DUF16 PF01519.16 ETO37021.1 - 4.4 7.9 11.7 12 6.5 11.7 1.7 1 1 0 1 1 1 0 Protein of unknown function DUF16 SelK_SelG PF10961.8 ETO37022.1 - 0.14 12.8 0.9 32 5.2 0.2 2.7 2 0 0 2 2 2 0 Selenoprotein SelK_SelG zf-CCHC PF00098.23 ETO37024.1 - 0.0041 17.1 6.1 0.0041 17.1 6.1 1.9 2 0 0 2 2 2 1 Zinc knuckle NUDIX PF00293.28 ETO37026.1 - 2.1e-10 40.7 0.0 1.4e-09 38.1 0.0 2.1 1 1 0 1 1 1 1 NUDIX domain zf-Di19 PF05605.12 ETO37026.1 - 0.00017 21.8 1.3 0.00041 20.6 1.3 1.7 1 0 0 1 1 1 1 Drought induced 19 protein (Di19), zinc-binding DUF3899 PF13038.6 ETO37028.1 - 0.51 10.9 2.5 4.7 7.8 0.2 2.1 2 0 0 2 2 2 0 Domain of unknown function (DUF3899) RVT_3 PF13456.6 ETO37029.1 - 0.019 14.8 0.1 0.047 13.5 0.1 1.6 1 0 0 1 1 1 0 Reverse transcriptase-like LIN52 PF10044.9 ETO37029.1 - 0.095 13.4 0.6 0.32 11.7 0.3 1.9 1 1 1 2 2 2 0 Retinal tissue protein DUF3437 PF11919.8 ETO37029.1 - 0.17 11.9 1.1 0.38 10.7 0.1 2.0 2 0 0 2 2 2 0 Domain of unknown function (DUF3437) RRM_1 PF00076.22 ETO37030.1 - 3.5e-33 113.3 0.7 1.2e-17 63.4 0.1 2.7 2 0 0 2 2 2 2 RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) Nup35_RRM_2 PF14605.6 ETO37030.1 - 4.3e-05 23.4 0.0 0.0051 16.8 0.0 2.5 2 0 0 2 2 2 1 Nup53/35/40-type RNA recognition motif Nup35_RRM PF05172.13 ETO37030.1 - 0.00023 21.1 0.1 0.78 9.7 0.0 2.6 2 0 0 2 2 2 2 Nup53/35/40-type RNA recognition motif RRM_occluded PF16842.5 ETO37030.1 - 0.00034 20.4 0.0 0.16 11.9 0.0 2.9 2 1 0 2 2 2 2 Occluded RNA-recognition motif RNA_bind PF08675.11 ETO37030.1 - 0.0026 17.8 0.1 0.0084 16.1 0.0 2.0 2 0 0 2 2 2 1 RNA binding domain DUF2956 PF11169.8 ETO37030.1 - 0.022 15.0 1.4 0.022 15.0 1.4 4.4 6 0 0 6 6 6 0 Protein of unknown function (DUF2956) Cwf_Cwc_15 PF04889.12 ETO37030.1 - 0.46 10.2 44.6 0.23 11.2 10.3 3.6 3 0 0 3 3 3 0 Cwf15/Cwc15 cell cycle control protein CDC45 PF02724.14 ETO37031.1 - 6.3 5.0 17.4 0.15 10.3 9.5 1.9 2 0 0 2 2 2 0 CDC45-like protein MS_channel PF00924.18 ETO37032.1 - 1.8e-11 44.0 5.3 2.5e-11 43.5 5.3 1.3 1 0 0 1 1 1 1 Mechanosensitive ion channel EF-hand_7 PF13499.6 ETO37032.1 - 0.11 13.0 0.2 0.29 11.6 0.1 1.8 2 0 0 2 2 2 0 EF-hand domain pair SAM_1 PF00536.30 ETO37033.1 - 2e-10 40.9 0.6 4.1e-10 39.9 0.6 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) SAM_2 PF07647.17 ETO37033.1 - 1e-08 35.1 0.3 2e-08 34.2 0.3 1.5 1 0 0 1 1 1 1 SAM domain (Sterile alpha motif) CDC45 PF02724.14 ETO37033.1 - 0.0077 14.6 6.8 0.0093 14.3 6.8 1.2 1 0 0 1 1 1 1 CDC45-like protein Presenilin PF01080.17 ETO37033.1 - 0.0077 15.0 3.0 0.01 14.7 3.0 1.2 1 0 0 1 1 1 1 Presenilin Zip PF02535.22 ETO37033.1 - 0.039 13.2 4.4 0.067 12.4 4.4 1.4 1 0 0 1 1 1 0 ZIP Zinc transporter PPL5 PF18168.1 ETO37033.1 - 0.075 12.3 7.1 0.14 11.4 7.1 1.4 1 0 0 1 1 1 0 Prim-pol family 5 DUF908 PF06012.12 ETO37033.1 - 0.1 12.0 3.5 0.14 11.6 3.5 1.2 1 0 0 1 1 1 0 Domain of Unknown Function (DUF908) RR_TM4-6 PF06459.12 ETO37033.1 - 0.41 10.4 15.7 0.62 9.8 15.7 1.2 1 0 0 1 1 1 0 Ryanodine Receptor TM 4-6 Pet20 PF08692.10 ETO37033.1 - 2.5 8.8 7.0 5 7.8 7.0 1.5 1 1 0 1 1 1 0 Mitochondrial protein Pet20 Coilin_N PF15862.5 ETO37033.1 - 3.4 7.5 19.1 0.28 11.0 13.3 2.0 1 1 1 2 2 2 0 Coilin N-terminus NPR3 PF03666.13 ETO37033.1 - 5.3 5.7 14.3 7.5 5.2 14.3 1.2 1 0 0 1 1 1 0 Nitrogen Permease regulator of amino acid transport activity 3 GCFC PF07842.12 ETO37035.1 - 5.9e-12 45.8 10.8 1.2e-06 28.4 0.3 3.0 3 0 0 3 3 3 2 GC-rich sequence DNA-binding factor-like protein RecU PF03838.14 ETO37036.1 - 0.24 11.4 3.8 6.4 6.8 1.1 2.2 2 0 0 2 2 2 0 Recombination protein U RAI1 PF08652.11 ETO37037.1 - 0.011 15.8 1.6 0.045 14.0 0.1 2.6 2 0 0 2 2 2 0 RAI1 like PD-(D/E)XK nuclease U1snRNP70_N PF12220.8 ETO37037.1 - 3.3 8.4 7.9 23 5.7 1.6 2.6 2 0 0 2 2 2 0 U1 small nuclear ribonucleoprotein of 70kDa MW N terminal Pyr_redox_2 PF07992.14 ETO37038.1 - 3.1e-40 138.3 0.0 7e-40 137.1 0.0 1.5 2 0 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_dim PF02852.22 ETO37038.1 - 1.6e-26 92.7 0.9 2.1e-25 89.1 0.6 2.7 2 1 0 2 2 2 1 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain Pyr_redox PF00070.27 ETO37038.1 - 1.7e-15 57.3 0.1 5.2e-15 55.8 0.1 1.8 1 0 0 1 1 1 1 Pyridine nucleotide-disulphide oxidoreductase Pyr_redox_3 PF13738.6 ETO37038.1 - 3e-14 53.0 0.0 1.4e-11 44.3 0.0 2.2 2 0 0 2 2 2 2 Pyridine nucleotide-disulphide oxidoreductase K_oxygenase PF13434.6 ETO37038.1 - 0.00076 18.7 0.0 0.012 14.8 0.0 2.3 1 1 1 2 2 2 1 L-lysine 6-monooxygenase (NADPH-requiring) 3HCDH_N PF02737.18 ETO37038.1 - 0.029 14.2 0.1 0.078 12.9 0.1 1.8 1 0 0 1 1 1 0 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain UDPG_MGDP_dh_N PF03721.14 ETO37038.1 - 0.086 12.4 0.1 0.18 11.3 0.1 1.6 1 0 0 1 1 1 0 UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain 2-Hacid_dh_C PF02826.19 ETO37038.1 - 0.09 12.1 0.0 0.28 10.5 0.0 1.8 2 0 0 2 2 2 0 D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain NAD_binding_7 PF13241.6 ETO37038.1 - 0.098 13.1 0.0 0.57 10.7 0.0 2.2 1 1 0 1 1 1 0 Putative NAD(P)-binding ApbA PF02558.16 ETO37038.1 - 0.11 12.1 0.0 2.1 8.0 0.0 2.4 2 0 0 2 2 2 0 Ketopantoate reductase PanE/ApbA DUF4576 PF15144.6 ETO37039.1 - 0.69 9.8 6.9 2.5 8.0 0.1 2.3 1 1 1 2 2 2 0 Domain of unknown function (DUF4576) Neur_chan_memb PF02932.16 ETO37040.1 - 0.00012 22.2 13.7 0.0012 19.0 9.2 2.2 2 0 0 2 2 2 2 Neurotransmitter-gated ion-channel transmembrane region DUF2070 PF09843.9 ETO37040.1 - 1.7 6.9 10.6 2.2 6.5 10.6 1.2 1 0 0 1 1 1 0 Predicted membrane protein (DUF2070) DUF4577 PF15145.6 ETO37041.1 - 0.002 18.1 0.6 0.0031 17.6 0.6 1.3 1 0 0 1 1 1 1 Domain of unknown function (DUF4577) TMEM154 PF15102.6 ETO37041.1 - 0.0029 17.5 1.2 0.0058 16.5 1.2 1.6 1 0 0 1 1 1 1 TMEM154 protein family Orf78 PF06024.12 ETO37041.1 - 0.0093 16.3 0.4 0.0093 16.3 0.4 1.8 2 0 0 2 2 2 1 Orf78 (ac78) Ctr PF04145.15 ETO37041.1 - 0.033 14.8 3.7 0.061 14.0 3.7 1.5 1 1 0 1 1 1 0 Ctr copper transporter family Herpes_gE PF02480.16 ETO37041.1 - 0.09 11.5 2.5 0.074 11.8 0.2 1.8 2 0 0 2 2 2 0 Alphaherpesvirus glycoprotein E LAP1C PF05609.12 ETO37041.1 - 0.12 11.4 0.7 0.16 11.0 0.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SKN1 PF03935.15 ETO37041.1 - 0.24 9.8 1.3 0.33 9.3 1.3 1.2 1 0 0 1 1 1 0 Beta-glucan synthesis-associated protein (SKN1) CTP_transf_1 PF01148.20 ETO37041.1 - 0.31 10.8 8.0 0.37 10.5 8.0 1.1 1 0 0 1 1 1 0 Cytidylyltransferase family LRRC37AB_C PF14914.6 ETO37041.1 - 0.84 9.5 7.1 0.061 13.2 1.8 1.8 2 1 0 2 2 2 0 LRRC37A/B like protein 1 C-terminal domain Ras PF00071.22 ETO37042.1 - 1.2e-40 138.7 8.4 5.7e-39 133.3 4.0 2.5 2 1 0 2 2 2 1 Ras family Roc PF08477.13 ETO37042.1 - 3.1e-29 101.6 2.4 2.4e-22 79.4 0.9 2.6 1 1 1 2 2 2 2 Ras of Complex, Roc, domain of DAPkinase Arf PF00025.21 ETO37042.1 - 7.9e-11 41.7 1.9 2.4e-10 40.2 0.9 2.0 2 0 0 2 2 2 1 ADP-ribosylation factor family GTP_EFTU PF00009.27 ETO37042.1 - 4.6e-07 29.6 0.4 6.9e-07 29.0 0.4 1.3 1 0 0 1 1 1 1 Elongation factor Tu GTP binding domain Gtr1_RagA PF04670.12 ETO37042.1 - 0.0022 17.4 1.2 0.0048 16.3 1.2 1.5 1 0 0 1 1 1 1 Gtr1/RagA G protein conserved region Ras PF00071.22 ETO37043.1 - 0.00016 21.3 0.3 0.0014 18.3 0.0 2.2 2 1 0 2 2 2 1 Ras family ORF6C PF10552.9 ETO37043.1 - 0.14 12.3 2.1 0.47 10.6 0.2 2.1 2 0 0 2 2 2 0 ORF6C domain Acetyltransf_1 PF00583.25 ETO37044.1 - 0.0022 18.2 0.1 0.0044 17.2 0.1 1.6 1 0 0 1 1 1 1 Acetyltransferase (GNAT) family tRNA-synt_1 PF00133.22 ETO37045.1 - 5.1e-138 461.0 9.5 3.1e-100 336.2 0.0 3.8 4 0 0 4 4 4 3 tRNA synthetases class I (I, L, M and V) Anticodon_1 PF08264.13 ETO37045.1 - 2.4e-19 69.8 0.1 5.9e-19 68.5 0.1 1.7 1 0 0 1 1 1 1 Anticodon-binding domain of tRNA tRNA-synt_1g PF09334.11 ETO37045.1 - 5.6e-05 22.1 0.3 0.14 10.9 0.0 2.7 3 0 0 3 3 3 2 tRNA synthetases class I (M) tRNA-synt_1e PF01406.19 ETO37045.1 - 0.0013 18.1 0.0 0.0044 16.4 0.0 1.9 1 0 0 1 1 1 1 tRNA synthetases class I (C) catalytic domain DUF2096 PF09869.9 ETO37045.1 - 0.12 12.4 0.5 1.4 9.0 0.2 2.4 2 0 0 2 2 2 0 Uncharacterized protein conserved in archaea (DUF2096) CLTH PF10607.9 ETO37045.1 - 0.16 11.9 0.5 0.56 10.1 0.1 2.1 2 0 0 2 2 2 0 CTLH/CRA C-terminal to LisH motif domain LAP1C PF05609.12 ETO37046.1 - 1.2 8.1 16.7 1.6 7.8 16.7 1.1 1 0 0 1 1 1 0 Lamina-associated polypeptide 1C (LAP1C) SprA-related PF12118.8 ETO37046.1 - 3 6.9 20.3 4 6.5 20.3 1.1 1 0 0 1 1 1 0 SprA-related family KOG2701 PF09762.9 ETO37047.1 - 2.7e-44 151.5 0.0 3.2e-44 151.3 0.0 1.1 1 0 0 1 1 1 1 Coiled-coil domain-containing protein (DUF2037) XPG_N PF00752.17 ETO37049.1 - 0.012 16.1 0.1 0.82 10.2 0.1 3.0 1 1 0 1 1 1 0 XPG N-terminal domain UTP15_C PF09384.10 ETO37049.1 - 0.13 12.0 0.8 0.24 11.1 0.1 1.8 2 0 0 2 2 2 0 UTP15 C terminal MtN3_slv PF03083.16 ETO37050.1 - 6.1e-30 103.1 9.9 1.9e-19 69.5 0.6 2.6 2 0 0 2 2 2 2 Sugar efflux transporter for intercellular exchange DUF373 PF04123.13 ETO37050.1 - 0.51 9.7 4.2 1.2 8.5 3.0 2.0 1 1 1 2 2 2 0 Domain of unknown function (DUF373) DUF3987 PF13148.6 ETO37051.1 - 0.11 11.5 0.1 0.12 11.4 0.1 1.0 1 0 0 1 1 1 0 Protein of unknown function (DUF3987) BRCT_2 PF16589.5 ETO37051.1 - 0.38 11.2 2.9 0.35 11.3 0.5 2.0 1 1 1 2 2 2 0 BRCT domain, a BRCA1 C-terminus domain Beach PF02138.18 ETO37053.1 - 1.3e-121 405.2 0.2 2.1e-121 404.5 0.2 1.3 1 0 0 1 1 1 1 Beige/BEACH domain WD40 PF00400.32 ETO37053.1 - 9.9e-10 38.9 11.3 1.4e-07 32.1 0.2 4.0 4 0 0 4 4 4 2 WD domain, G-beta repeat ANAPC4_WD40 PF12894.7 ETO37053.1 - 8.9e-05 22.7 0.1 0.0017 18.6 0.0 2.4 1 1 0 2 2 2 1 Anaphase-promoting complex subunit 4 WD40 domain PhoLip_ATPase_C PF16212.5 ETO37054.1 - 2.8e-78 263.1 26.5 2.8e-78 263.1 26.5 1.7 2 0 0 2 2 2 1 Phospholipid-translocating P-type ATPase C-terminal Hydrolase PF00702.26 ETO37054.1 - 1.7e-11 44.9 0.3 0.0013 19.0 0.1 3.4 3 0 0 3 3 3 2 haloacid dehalogenase-like hydrolase Cation_ATPase PF13246.6 ETO37054.1 - 2e-10 40.6 2.1 9.6e-10 38.4 1.2 2.5 2 0 0 2 2 2 1 Cation transport ATPase (P-type) Hydrolase_3 PF08282.12 ETO37054.1 - 0.00012 21.9 4.0 0.0039 17.0 0.0 3.1 3 0 0 3 3 3 1 haloacid dehalogenase-like hydrolase RNA_pol_Rpc4 PF05132.14 ETO37054.1 - 0.2 12.1 3.2 0.51 10.8 3.2 1.7 1 0 0 1 1 1 0 RNA polymerase III RPC4 RP-C_C PF11800.8 ETO37054.1 - 0.42 10.7 5.4 0.83 9.7 5.4 1.4 1 0 0 1 1 1 0 Replication protein C C-terminal region FAM176 PF14851.6 ETO37054.1 - 0.89 9.2 7.8 2.8 7.6 7.8 1.9 1 0 0 1 1 1 0 FAM176 family CobT PF06213.12 ETO37054.1 - 1.3 8.3 10.7 2.7 7.3 10.7 1.4 1 0 0 1 1 1 0 Cobalamin biosynthesis protein CobT RR_TM4-6 PF06459.12 ETO37054.1 - 1.7 8.4 16.3 4.8 6.9 16.3 1.8 1 1 0 1 1 1 0 Ryanodine Receptor TM 4-6 PhoLip_ATPase_N PF16209.5 ETO37055.1 - 1.2e-14 53.7 3.6 1.3e-12 47.2 0.2 2.8 3 0 0 3 3 3 2 Phospholipid-translocating ATPase N-terminal E1-E2_ATPase PF00122.20 ETO37055.1 - 0.005 16.4 0.2 0.012 15.2 0.0 1.7 2 0 0 2 2 2 1 E1-E2 ATPase EpsG PF14897.6 ETO37055.1 - 0.0076 15.6 5.8 0.013 14.8 5.8 1.4 1 0 0 1 1 1 1 EpsG family RseC_MucC PF04246.12 ETO37055.1 - 0.027 14.4 0.5 7.9 6.4 0.2 2.4 2 0 0 2 2 2 0 Positive regulator of sigma(E), RseC/MucC UCH PF00443.29 ETO37056.1 - 1.1e-29 103.8 4.3 1.1e-29 103.8 4.3 2.7 3 0 0 3 3 3 1 Ubiquitin carboxyl-terminal hydrolase UCH_1 PF13423.6 ETO37056.1 - 7.8e-14 52.0 6.9 7.8e-14 52.0 6.9 2.3 2 0 0 2 2 2 1 Ubiquitin carboxyl-terminal hydrolase DUF4352 PF11611.8 ETO37056.1 - 0.014 15.7 0.0 0.055 13.8 0.0 2.0 1 0 0 1 1 1 0 Domain of unknown function (DUF4352) T6_Ig_like PF18002.1 ETO37056.1 - 0.037 13.9 0.0 0.081 12.8 0.0 1.4 1 0 0 1 1 1 0 T6 antigen Ig like domain NUC130_3NT PF08158.12 ETO37056.1 - 0.039 14.3 0.4 0.5 10.7 0.1 2.8 2 0 0 2 2 2 0 NUC130/3NT domain AUX_IAA PF02309.16 ETO37056.1 - 0.77 9.6 3.7 0.38 10.6 0.2 2.3 3 0 0 3 3 3 0 AUX/IAA family Cation_ATPase PF13246.6 ETO37057.1 - 0.0076 16.3 0.0 0.012 15.7 0.0 1.3 1 0 0 1 1 1 1 Cation transport ATPase (P-type) MSC PF09402.10 ETO37058.1 - 0.13 11.7 1.5 0.15 11.5 0.6 1.5 1 1 0 1 1 1 0 Man1-Src1p-C-terminal domain Type2_restr_D3 PF16902.5 ETO37058.1 - 0.13 12.1 0.4 0.13 12.1 0.4 1.7 2 0 0 2 2 2 0 Type-2 restriction enzyme D3 domain Baculo_PEP_C PF04513.12 ETO37061.1 - 0.0067 16.5 0.9 0.016 15.2 0.9 1.6 1 1 0 1 1 1 1 Baculovirus polyhedron envelope protein, PEP, C terminus # # Program: hmmscan # Version: 3.2.1 (June 2018) # Pipeline mode: SCAN # Query file: /oak/stanford/groups/akundaje/marinovg/genomes/Foraminifera/Reticulomyxa_filosa-1.0/GCA_000512085.1_Reti_assembly1.0_protein.faa # Target file: /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm # Option settings: /oak/stanford/groups/akundaje/marinovg/programs/hmmer-3.2.1/bin/hmmscan -o /oak/stanford/groups/akundaje/marinovg/genomes/Foraminifera/Reticulomyxa_filosa-1.0/GCA_000512085.1_Reti_assembly1.0_protein.PFam32-A --tblout /oak/stanford/groups/akundaje/marinovg/genomes/Foraminifera/Reticulomyxa_filosa-1.0/GCA_000512085.1_Reti_assembly1.0_protein.PFam32-A.tblout --cpu 20 /oak/stanford/groups/akundaje/marinovg/genomes/PFam/PFam32.0/Pfam-A.hmm /oak/stanford/groups/akundaje/marinovg/genomes/Foraminifera/Reticulomyxa_filosa-1.0/GCA_000512085.1_Reti_assembly1.0_protein.faa # Current dir: /oak/stanford/groups/akundaje/marinovg/genomes # Date: Sun Mar 24 14:07:06 2019 # [ok]